bluuebunny/crossref_metadata_2025_split huggingface dataset:
An unusual case of chest wall glomus tumor presenting with axillary pain: a case report and literature review
Authors: Zanjani Leila Oryadi , Shafiee Nia Bahman , Vosoughi Farzad , Mirzaian Elham , Aghaghazvini Leila , Arabzadeh Aidin 
Published: May 2021

Abstract
Background
Glomus tumor is an uncommon soft tissue tumor. However, as the tumor causes significant disability, its early diagnosis is essential. It involves subungual areas of fingers and toes in most cases, and its extra-digital involvement is rarely seen. To the best of the authors' knowledge, only a few chest wall involvement cases have been reported in the literature.

Case presentation
In this paper, we describe a 63-year-old patient with a chest wall glomus tumor presenting with axillary paroxysmal pain and limitation in his shoulder range of motion that had been missed for nearly 15 years. His symptoms were relieved immediately following surgical excision.

Conclusion
Glomus tumors may involve any part of the human body. It is curable with surgical excision in most cases. Therefore, a correct early diagnosis has paramount importance. A high index of suspicion is needed for early diagnosis, especially when the tumor involves uncommon anatomic areas.
Prevalence of Plasmodium falciparum isolates lacking the histidine rich protein 2 gene among symptomatic malaria patients in Kwilu Province of the Democratic Republic of Congo
Authors: Munyeku Yannick Bazitama , Musaka Alain Abera , Ernest Medard , Smith Chris , Mansiangi Paul Mankadi , Culleton Richard 
Published: May 2021

Abstract
Background
Malaria rapid diagnostic tests have become a primary and critical tool for malaria diagnosis in malaria-endemic countries where Plasmodium falciparum Histidine Rich Protein 2-based rapid diagnostic tests (PfHRP2-based RDTs) are widely used. However, in the last decade, the accuracy of PfHRP2-based RDTs has been challenged by the emergence of P. falciparum strains harbouring deletions of the P. falciparum histidine rich protein 2 (pfhrp2) gene, resulting in false-negative results. In the Democratic Republic of Congo (D.R. Congo), little is known about the prevalence of the pfhrp2 gene deletion among P. falciparum isolates infecting symptomatic patients, especially in low to moderate transmission areas where pfhrp2 deletion parasites are assumed to emerge and spread. Here we determine the local prevalence and factors associated with pfhrp2 gene deletions among symptomatic malaria patients in the Kwilu Province of the D.R. Congo.

Methods
We used secondary data from a prospective health facility-based cross-sectional study conducted in 2018. Blood was collected for microscopy, PfHRP2-RDT, and spotted onto Whatman filter paper for downstream genetic analysis. Genomic DNA was extracted and used to perform PCR assays for the detection and confirmation of pfhrp2 gene deletions. Fischer’s exact and the Kruskal–Wallis tests were applied to look for associations between potential explanatory variables and the pfhrp2 gene deletion with a level of statistical significance set at P < 0.05.

Results
Of the 684 enrolled symptomatic patients, 391 (57.7%) were female. The majority (87.7%) reported the presence of mosquito breeding sites within the household’s compound, and fever was the most reported symptom (81.6%). The overall prevalence of the pfhrp2 gene deletion was 9.2% (95% CI: 6.7%–12.1%). The deletion of the pfhrp2 gene was associated with health zone of origin (P = 0.012) and age (P = 0.019). Among false-negative PfHRP2-RDT results, only 9.9% were due to pfhrp2 gene deletion.

Conclusions
P. falciparum isolates with pfhrp2 gene deletions are relatively common among symptomatic patients in Kwilu province. Further investigations are needed to provide enough evidence for policy change. Meanwhile, the use of RDTs targeting PfHRP2 and parasite lactate dehydrogenase (pLDH) antigens could limit the spread of deleted isolates.

Graphic Abstract
Humic substances from green compost increase bioactivity and antibacterial properties of essential oils in Basil leaves
Authors: Verrillo Mariavittoria , Cozzolino Vincenza , Spaccini Riccardo , Piccolo Alessandro 
Published: May 2021

Abstract
Background
The Essential oils (EOs) are important bioactive secondary metabolites of aromatic plants, such as Basil, and find extensive utilization in pharmaceutical sector as therapeutic agents. A more eco-friendly industrial production of EOs requires new sustainable methods to improve yield and quality of these bioactive compounds in aromatic plants. Here, we evaluated the biostimulation effects of natural organic materials, such as humic substances (HS) extracted from a humified green compost made with artichoke biomasses.

Results
The molecular characteristics of HS from green compost were determined by 13C-CPMAS NMR spectroscopy and offline pyrolysis–gas chromatography/mass spectrometry and combined to the bioactivity of the EOs extracts to investigate the structural–activity relationship. Basil plants were grown under HS treatments at different concentrations and the yield, the chemical composition and the antioxidant and antimicrobial properties were determined for EOs extracted by steam distillation method from Basil leaves. HS showed a positive effect on total extraction yield of the most bioactive EO components, with a progressive enhancement of abundance for eugenol, eucalyptol and geranyl acetate with increasing HS concentrations. Humic biostimulation influenced the EOs antioxidant proprieties, as well as their antimicrobial activity against some common Gram-negative bacterial strains such as Klebsiella pneumoniae. The HS biostimulation of Basil plants was associated to their structural hydrophobic characteristics that may have favoured the interactions with the Basil rhizome and to specific bioactive molecular components, such as a lignin-derived phenols and polar saccharidic and aminoacidic compounds.

Conclusions
Our results support the potential use of humic substances from green compost as promising effective biostimulants to improve the production and bioactive properties of EOs in aromatic plants.

Graphic Abstract
Campaigning across continents: how Latin American parties link up with migrant associations abroad
Authors: Fliess Nicolas 
Published: May 2021

AbstractEmigrant voting rights have opened new electoral arenas, and many political parties increasingly campaign across borders. Yet relatively little is known about the challenges parties confront when campaigning transnationally and the strategies they have developed in response to these challenges. This paper addresses these shortcomings. First, I investigate the hurdles Latin American parties face in linking up with organized migrant collectives in residency countries for campaigning purposes. Second, I probe into the transnational linkage strategies these parties deploy to tap into migrant associations’ resources and mobilization capacities. This study builds on a comparative research design and draws on almost 40 semi-structured interviews with Bolivian and Ecuadorian party activists as well as association leaders in Barcelona, Spain. Departing from the party interest group literature, I identify three transnational linkage strategies Bolivian and Ecuadorian parties implement: 1) Infiltration, 2) Co-optation, and 3) Cooperation. All parties execute these tactics informally in order to comply with local norms that require associations to remain apolitical. The analysis further demonstrates that differences between home-country electoral systems shape the types of linkage strategies Bolivian and Ecuadorian parties use. This article contributes to the study of migrant politics and political parties in important ways. This study highlights how political parties actively negotiate their entry into the transnational electoral arena, and sheds light on how migrants remain politically connected to their home countries.
Unilateral acute posterior multifocal placoid pigment epitheliopathy in a convalescent COVID-19 patient
Authors: Olguín-Manríquez Francisco , Cernichiaro-Espinosa Linda , Olguín-Manríquez Arturo , Manríquez-Arias Rebeca , Flores-Villalobos Erick Omar , Kawakami-Campos Perla Ayumi 
Published: May 2021

Abstract
Background
To report a case of unilateral acute posterior multifocal placoid pigment epitheliopathy (APMPPE) in a Hispanic convalescent COVID-19 female patient.
Case presentation
A 35-year-old Hispanic female with exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was evaluated due to unilateral visual loss. Ophthalmic examination and diagnostic tests were consistent with APMPPE.

Discussion
Ocular changes can be observed in patients with COVID-19. A complete ophthalmic evaluation must be performed in patients with low vision after SARS-CoV-2 infection.
Production of scandium radionuclides for theranostic applications: towards standardization of quality requirements
Authors: Mikolajczak R. , Huclier-Markai S. , Alliot C. , Haddad F. , Szikra D. , Forgacs V. , Garnuszek P. 
Published: May 2021

AbstractIn the frame of “precision medicine”, the scandium radionuclides have recently received considerable interest, providing personalised adjustment of radiation characteristics to optimize the efficiency of medical care or therapeutic benefit for particular groups of patients. Radionuclides of scandium, namely scandium-43 and scandium-44 (43/44Sc) as positron emitters and scandium-47 (47Sc), beta-radiation emitter, seem to fit ideally into the concept of theranostic pair. This paper aims to review the work on scandium isotopes production, coordination chemistry, radiolabeling, preclinical studies and the very first clinical studies. Finally, standardized procedures for scandium-based radiopharmaceuticals have been proposed as a basis to pave the way for elaboration of the Ph.Eur. monographs for perspective scandium radionuclides.
Morpho-meristics, maturity stages, GSI and gonadal hormone plasticity of African catfish Clarias gariepinus (Burchell 1822) that invaded into the Ganga River, India
Authors: Singh Atul K. , Ansari Abubakar , Srivastava Sharad C. 
Published: May 2021

Abstract
Background
African catfish Clarias gariepinus introduced to India has gravitated into the Ganga River as an invasive species. Morphological plasticity and reproductive adaptation are considered and reported as important manifestation contributing to evolution and persistence of an invasive species in the novel environment facilitating its expansion and establishment. African catfish in the Ganga River although documented to exist, it is yet to investigate if it elicits adaptation responses through morphological and reproductive plasticity in the riverine conditions. Therefore, morpho-meristic changes, plasticity in the reproductive stages, gonadosomatic index (GSI) and gonadal hormones were examined in C. gariepinus that invaded into the Ganga River so as to ascertain its invasion success.

Results
Out of 23 morpho-meristic characters examined, head length (HL), head depth (HD), anal fin length (AFL) and the pectoral fin rays (PECFR) were observed to differ significantly (p<0.05). The correlation coefficient ‘r’ between log length and log weight was found to be 0.9690 in culture and 0.8754 in river-caught specimens respectively. A distinct deviation in the maturity stages, GSI as well as gonadal hormones (testosterone, estradiol 17-β and vitellogenin) was further observed to change significantly in specimens of African catfish captured from the Ganga River as compared to those available in culture. Highest level of testosterone was found in males having gonadal stage V which was 184.82±10.4 pg/ml in culture and 204.82±21.34 pg/ml in river-captured specimens. The mean value of serum estradiol-17β was lowest (67.25±11.4 pg/ml) in gonadal maturity stage I and highest (328.73±24.5 pg/ml) in stage V in the river-captured C. gariepinus. The vitellogenin level in female C. gariepinus was detected in stage III, and it was maximum in stage V where it was 16.68±2.98 pg/ml in river-captured specimens and 12.63±2.12 pg/ml in cultured fish.

Conclusion
The results of this study on morpho-meristic and gonadal plasticity provide first evidence of invasion success of the African catfish gravitated in the Ganga River which has now adapted to the river environments for breeding and establishing. The variations concerning different reproductive phases and the gonadal hormones in culture and river-caught C. gariepinus have been considered to contribute to the success of the colonisation and establishment. The knowledge generated on the phenotypic and reproductive plasticity of African catfish available in the Ganga River will help management and control programmes.
Determinants of quality of life changes with plasmapheresis in patients with myasthenia gravis
Authors: Al-Ahmer Ibraheim , Elshony Hosna 
Published: May 2021

Abstract
Background
Immunomodulation, including IVIG and plasma exchange, is useful for a crisis or severe exacerbation. Plasma exchange may be slightly faster and more effective in a myasthenic crisis than IVIG. The aim of the current study was to determine the changes in the quality of life (QOL) after plasmapheresis and factors influencing these changes.

Results
This study was conducted on 98 MG patients diagnosed as moderate to severe myasthenia gravis (according to Myasthenia Gravis Foundation of America classification), 81 patients received alternate day 5 sessions plasmapheresis (TPE group) and 17 patients were on medical treatment only (control group). All patients were subjected to full history, through clinical neurological evaluation and scored with quantitative myasthenia gravis (QMG) score for MG severity at start and after 1 m. Both groups completed the QOL questionnaire at baseline and after 1 month. The MG-QOL-15 scores were computed and we analyzed the change in the QOL scores from baseline to after plasmapheresis groups and compared it with the results for the control group. The scores in QOL scales had significantly decreased after plasmapheresis, and the improvement in QOL scores had a good correlation with the decrease in QMGS. The improvement in QOL and QMG was significantly correlated with younger age, female gender, shorter duration of the illness, presence of AchR antibodies, antibody titer, and thymus hyperplasia.

Conclusion
Plasmapheresis is effective in improving quality of life in myasthenia gravis patients and this improvement influenced by age, gender, duration of illness, presence of AchR antibodies and their titer, and the thymus pathology.
Overview of therapeutic applications of non-invasive vagus nerve stimulation: a motivation for novel treatments for systemic lupus erythematosus
Authors: Ramkissoon Charrise M. , Güemes Amparo , Vehi Josep 
Published: May 2021

AbstractSystemic lupus erythematosus (SLE) is a chronic systemic autoimmune disorder that commonly affects the skin, joints, kidneys, and central nervous system. Although great progress has been made over the years, patients still experience unfavorable secondary effects from medications, increased economic burden, and higher mortality rates compared to the general population. To alleviate these current problems, non-invasive, non-pharmacological interventions are being increasingly investigated. One such intervention is non-invasive vagus nerve stimulation, which promotes the upregulation of the cholinergic anti-inflammatory pathway that reduces the activation and production of pro-inflammatory cytokines and reactive oxygen species, culpable processes in autoimmune diseases such as SLE. This review first provides a background on the important contribution of the autonomic nervous system to the pathogenesis of SLE. The gross and structural anatomy of the vagus nerve and its contribution to the inflammatory response are described afterwards to provide a general understanding of the impact of stimulating the vagus nerve. Finally, an overview of current clinical applications of invasive and non-invasive vagus nerve stimulation for a variety of diseases, including those with similar symptoms to the ones in SLE, is presented and discussed. Overall, the review presents neuromodulation as a promising strategy to alleviate SLE symptoms and potentially reverse the disease.
Longitudinal Associations of Sedentary Behavior and Physical Activity with Quality of Life in Colorectal Cancer Survivors
Authors: KENKHUIS MARLOU FLOOR , VAN ROEKEL ELINE H. , BREEDVELD-PETERS JOSÉ J. L. , BREUKINK STÉPHANIE O. , JANSSEN-HEIJNEN MARYSKA L. G. , KEULEN ERIC T. P. , VAN DUIJNHOVEN FRÄNZEL J. B. , MOLS FLOORTJE , WEIJENBERG MATTY P. , BOURS MARTIJN J. L. 
Published: May 2021

ABSTRACT

Introduction
Given the growing population of colorectal cancer (CRC) survivors, identifying ways to enhance health-related quality of life (HRQoL) and alleviate complaints of fatigue and chemotherapy-induced peripheral neuropathy (CIPN) is essential.

Purpose
We aimed to assess longitudinal associations of sedentary behavior (SB) and moderate to vigorous physical activity (MVPA) independently, as well as their joint association, with HRQoL, fatigue, and CIPN in CRC survivors.

Methods
In a prospective cohort among stage I–stage III CRC survivors (n = 396), five repeated home visits from diagnosis up to 24 months posttreatment were executed. SB was measured using triaxial accelerometers, and MVPA, HRQoL, fatigue, and CIPN were measured by validated questionnaires. We applied confounder-adjusted linear mixed models to analyze longitudinal associations from 6 wk until 24 months posttreatment.

Results
Average time in prolonged SB (accumulated in bouts of duration ≥30 min) was 5.3 ± 2.7 h·d−1, and approximately 82% of survivors were classified as sufficiently active (≥150 min·wk−1 of MVPA) at 6 wk posttreatment. Decreases in SB and increases in MVPA were independently associated with better HRQoL and less fatigue over time. No associations were found for CIPN complaints. A synergistic interaction was observed between prolonged SB and MVPA in affecting functioning scales. Relative to CRC survivors with low prolonged SB and high MVPA, survivors with high prolonged SB and low MVPA reported a stronger decrease in physical functioning and role functioning over time than expected based on the independent associations of prolonged SB and MVPA.

Conclusion
Our longitudinal results show that less SB and more MVPA are beneficial for CRC survivors’ HRQoL and fatigue levels. Our findings regarding interaction underscore that joint recommendations to avoid prolonged sitting and accumulate MVPA are important.
Ain’t Just Imagination! Effects of Motor Imagery Training on Strength and Power Performance of Athletes during Detraining
Authors: DELLO IACONO ANTONIO , ASHCROFT KURTIS , ZUBAC DAMIR 
Published: May 2021

ABSTRACT

Purpose
This study aimed to investigate the effects of motor imagery (MI) training on strength and power performances of professional athletes during a period of detraining caused by the COVID-19 outbreak.

Methods
Thirty male professional basketball players (age, 26.1 ± 6.2 yr) were randomly assigned to three counterbalanced groups: two MI training groups, who completed imagery training by mentally rehearsing upper and lower limb resistance training exercises loaded with either 85% of one repetition maximum (85%1RM) or optimum power loads (OPL), or a control group. For six consecutive weeks, although all groups completed two weekly sessions of high-intensity running, only the MI groups performed three additional MI sessions a week. Maximal strength and power output were measured through 1RM and OPL assessments in the back squat and bench press exercises with a linear positioning transducer. Vertical jump and throwing capabilities were assessed with the countermovement jump and the seated medicine ball throw tests, respectively. Kinesthetic and visual imagery questionnaires, and chronometry and rating of perceived effort scores were collected to evaluate MI vividness, MI ability, and perceived effort.

Results
Physical performances improved significantly following both MI protocols (range, ~2% to ~9%), but were reduced in the control group, compared with preintervention (P ≤ 0.016). Moreover, interactions (time–protocol) were identified between the two MI groups (P ≤ 0.001). Whereas the 85%1RM led to greater effects on maximal strength measures than the OPL, the latter induced superior responses on measures of lower limb power. These findings were mirrored by corresponding cognitive and psychophysiological responses.

Conclusions
During periods of forced detraining, MI practice seems to be a viable tool to maintain and increase physical performance capacity among professional athletes.
Von Befestigungen und Grossbaustellen
Authors: Hagendorn Andrea , Stegmüller Christian , Stelzle-Hüglin Sophie , Alder Cornelia , Doppler Thomas , Keller Daniel , Pümpin Christine , Rentzel Philippe 
Published: May 2021

Die Ausgrabung fand im praktisch nicht überbauten Hofareal statt. Die Kulturschichten waren hier ausserordentlich gut erhalten und hatten eine durchschnittliche Mächtigkeit von fast 3 Metern.
Die Ränder des an der nördlichen Spitze des Basler Münsterhügels gelegenen Martinskirchsporns fallen steil zu Rhein und Birsig hin ab. Aufgrund der natürlichen Schutzlage wurde dieser Teil des Plateaus bereits in der späten Bronzezeit (um 1200-800 v. Chr.) zur Befestigung ausgebaut. Kontinuierlich bis heute besiedelt wurde der Basler Münsterhügel jedoch erst ab der Spätlatenezeit (ca. 80/70 v. Chr.)
Auf der Ausgrabung konnten Zeugnisse aus 3000 Jahren Besiedlungsgeschichte erfasst werden.
A dataset for the analysis of antibody response to glycan alpha-Gal in individuals with immune-mediated disorders
Authors: de la Fuente José , Urra José Miguel , Contreras Marinela , Pacheco Iván , Ferreras-Colino Elisa , Doncel-Pérez Ernesto , Fernández de Mera Isabel G. , Villar Margarita , Cabrera Carmen M. , Gómez Hernando Cesar , Vargas Baquero Eduardo , Blanco García Javier , Rodríguez Gómez Javier , Velayos Galán Alberto , Feo Brito Francisco , Gómez Torrijos Elisa , Cabezas-Cruz Alejandro , Gortázar Christian 
Published: May 2021

Humans evolved by losing the capacity to synthesize the glycan Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal), which resulted in the development of a protective response mediated by anti-α-Gal IgM/IgG/IgA antibodies against pathogens containing this modification on membrane proteins. As an evolutionary trade-off, humans can develop the alpha-Gal syndrome (AGS), a recently diagnosed disease mediated by anti-α-Gal IgE antibodies and associated with allergic reactions to mammalian meat consumption and tick bites. However, the anti-α-Gal antibody response may be associated with other immune-mediated disorders such as those occurring in patients with COVID-19 and Guillain-Barré syndrome (GBS). Here, we provide a dataset (209 entries) on the IgE/IgM/IgG/IgA anti-α-Gal antibody response in healthy individuals and patients diagnosed with AGS, tick-borne allergies, GBS and COVID-19. The data allows correlative analyses of the anti-α-Gal antibody response with factors such as patient and clinical characteristics, record of tick bites, blood group, age and sex. These analyses could provide insights into the role of anti-α-Gal antibody response in disease symptomatology and possible protective mechanisms.