bluuebunny/crossref_metadata_2025_split huggingface dataset:
Terahertz focusing metalens of reflectionless meta-atoms with negative refractive indices
Authors: Nakao Haruaki , Kondoh Satoshi , Suzuki Takehito 
Published: April 2021

Terahertz continuous-wave (CW) sources oscillating around the 1.0 THz band at room temperature have rapidly been developed to bridge the terahertz gap. However, reflectionless metasurfaces suitable for integration with terahertz CW sources as optical components have yet to be developed in the terahertz gap. Here, we propose a terahertz-focusing metalens consisting of reflectionless meta-atoms with a discrete distribution of negative refractive indices from

−

1.1

to

−

2.8

. The proposed 2D gradient-refractive-index metalens converts an incident terahertz Gaussian beam to a line focus. We also experimentally demonstrate a metasurface of reflectionless meta-atoms with a negative refractive index of

−

2.8

adopted in the periphery of the metalens. The reflectionless metasurface in the terahertz gap would be a welcome contribution to the rapid growth of terahertz industrial applications with terahertz CW sources. Further, the design approach based on reflectionless meta-atoms with negative refractive indices could be applied to various 2D planar optical components with attractive functionalities such as collimating, arbitrary wavefront shaping, and light vortices.
Characterization and functional analysis of the proteins Prohibitin 1 and 2 in Trypanosoma cruzi
Authors: Ibarrola-Vannucci Ana K. , De Pablos Luis M. , Retana-Moreira Lissette , Cornet-Gomez Alberto , Cruz-Bustos Teresa , Schijman Alejandro G. , Ramírez José L. , Vílchez Susana , Osuna Antonio 
Published: April 2021

BackgroundChagas disease is the third most important neglected tropical disease. There is no vaccine available, and only two drugs are generally prescribed for the treatment, both of which with a wide range of side effects. Our study ofT.cruziPHBs revealed a pleiotropic function in different stages of the parasite, participating actively in the transformation of the non-infective replicative epimastigote form into metacyclic trypomastigotes and also in the multiplication of intracellular amastigotes.Methodology/principal findingsTo obtain and confirm our results, we applied several tools and techniques such as electron microscopy, immuno-electron microscopy, bioinformatics analysis and molecular biology. We transfectedT.cruziclones with the PHB genes, in order to overexpress the proteins and performed a CRISPR/Cas9 disruption to obtain partially silenced PHB1 parasites or completely silenced PHB2 parasites. The function of these proteins was also studied in the biology of the parasite, specifically in the transformation rate from non-infective forms to the metacyclic infective forms, and in their capacity of intracellular multiplication.Conclusion/significanceThis research expands our understanding of the functions of PHBs in the life cycle of the parasite. It also highlights the protective role of prohibitins against ROS and reveals that the absence of PHB2 has a lethal effect on the parasite, a fact that could support the consideration of this protein as a possible target for therapeutic action.
Association between acoustic speech features and non-severe levels of anxiety and depression symptoms across lifespan
Authors: Albuquerque Luciana , Valente Ana Rita S. , Teixeira António , Figueiredo Daniela , Sa-Couto Pedro , Oliveira Catarina 
Published: April 2021

BackgroundSeveral studies have investigated the acoustic effects of diagnosed anxiety and depression. Anxiety and depression are not characteristics of the typical aging process, but minimal or mild symptoms can appear and evolve with age. However, the knowledge about the association between speech and anxiety or depression is scarce for minimal/mild symptoms, typical of healthy aging. As longevity and aging are still a new phenomenon worldwide, posing also several clinical challenges, it is important to improve our understanding of non-severe mood symptoms’ impact on acoustic features across lifetime. The purpose of this study was to determine if variations in acoustic measures of voice are associated with non-severe anxiety or depression symptoms in adult population across lifetime.MethodsTwo different speech tasks (reading vowels in disyllabic words and describing a picture) were produced by 112 individuals aged 35-97. To assess anxiety and depression symptoms, the Hospital Anxiety Depression Scale (HADS) was used. The association between the segmental and suprasegmental acoustic parameters and HADS scores were analyzed using the linear multiple regression technique.ResultsThe number of participants with presence of anxiety or depression symptoms is low (>7: 26.8% and 10.7%, respectively) and non-severe (HADS-A: 5.4 ± 2.9 and HADS-D: 4.2 ± 2.7, respectively). Adults with higher anxiety symptoms did not present significant relationships associated with the acoustic parameters studied. Adults with increased depressive symptoms presented higher vowel duration, longer total pause duration and short total speech duration. Finally, age presented a positive and significant effect only for depressive symptoms, showing that older participants tend to have more depressive symptoms.ConclusionsNon-severe depression symptoms can be related to some acoustic parameters and age. Depression symptoms can be explained by acoustic parameters even among individuals without severe symptom levels.
Evaluation of the performance of health extension workers on malaria rapid diagnostic tests and predictor factors in Bahir Dar Zuria district, northwest Ethiopia: A cross-sectional study
Authors: Dejazmach Zelalem , Alemu Getaneh , Yimer Mulat , Muluneh Chalachew , Tegegne Banchamlak 
Published: April 2021

Background
In Ethiopia, anti-malaria treatment is initiated after parasitological confirmation using blood film microscopy at health centers and hospitals, or serological rapid diagnostic tests at health posts. At health posts, the diagnosis is performed by health extension workers using rapid diagnostic tests after little training. However, there is paucity of data about the health extension workers’ performance on rapid diagnostic tests. Hence, periodic monitoring of the performances of health extension workers on malaria rapid diagnostic tests and predicted factors plays a pivotal role for the control of malaria.

Methods
A cross sectional study was conducted in May 2020, among 75 health extension workers working at health posts in Bahir Dar Zuria district, Northwest Ethiopia. Their performance on malaria rapid diagnostic tests was assessed by distributing known positive and negative samples as confirmed by investigators using both rapid diagnostic test and blood film microscopy. Test results from health extension workers were then compared with that of investigators. Procedural errors committed while performing the tests were assessed using observational checklist. Data were analyzed using SPSS software version 20.

Results
The overall sensitivity and specificity of health extension workers in detecting Plasmodium species were 96.8% and 98.7%, respectively with 97.3% result agreement between the health extension workers and investigators (kappa value = 0.949). The most common procedural errors committed by health extension workers was ‘not checking expiry date of the test kits’ followed by ‘not adhering to the appropriate time of reading results’ that 70.7% and 64% of the participants committed these errors, respectively. Total number of procedural errors committed by those who have got in-service training was decreased by 47.3% as compared to those without in-service training.

Conclusions
Health extension workers had high performance on malaria rapid diagnostic tests. However, in-service training and periodic supervision should be given in order to maximize performance on these tests.
Effects of changes in regular physical activity status on hip fracture: A nationwide population-based cohort study in Korea
Authors: Han Sangsoo , Jang Hae-Dong , Nah Sangun , Han Kyungdo , Lim Hyunwoong , Kim Won Seok , Hong Jae-Young 
Published: April 2021

Objective
Hip fracture incidence is increasing with rapid aging of the population and regular physical activity (RPA) is an important modifiable protective factor for fracture. However, the association between the risk of hip fractures and changes in RPA status in the general population remains unknown. Thus, we explore the association between the risk of hip fracture and changes in RPA status.

Methods
We studied 4,984,144 individuals without fractures within a year whose data were registered in the Korean National Health Insurance Service database. Baseline physical activity level was assessed using a standardized self-reported questionnaire during two consecutive national health screening surveys performed in Korea from 2009 to 2012. The risk of hip fracture between 2013 and 2016 according to change in RPA was prospectively analyzed. Participants were divided into those who were always inactive, became inactive, became active, and were always active.

Results
Compared to participants who were always inactive, those who became inactive exhibited a 0.12/1,000 person-years (PY) reduction in hip fracture incidence rate (IR) [aHR: 0.865; 95% confidence interval (CI): 0.824–0.908]. Participants who became active, and those who were always active, exhibited a 0.24/1,000 PY reduction in IR (aHR: 0.827; 95% CI: 0.787–0.870) and a 0.39/1,000 PY reduction in IR (aHR: 0.691; 95% CI: 0.646–0.740), respectively.

Conclusion
Changes in RPA status were associated with the risk of hip fracture; consistent RPA was related to the maximum benefit for risk reduction in the general population.
Sex-differences in circulating biomarkers during acute myocardial infarction: An analysis from the SWEDEHEART registry
Authors: Eggers Kai M. , Lindhagen Lars , Baron Tomasz , Erlinge David , Hjort Marcus , Jernberg Tomas , Johnston Nina , Marko-Varga György , Rezeli Melinda , Spaak Jonas , Lindahl Bertil 
Published: April 2021

Background
Sex-differences in the pathobiology of myocardial infarction are well established but incompletely understood. Improved knowledge on this topic may help clinicians to improve management of men and women with myocardial infarction.

Methods
In this registry-based cohort study (SWEDEHEART), we analyzed 175 circulating biomarkers reflecting various pathobiological axes in 856 men and 243 women admitted to Swedish coronary care units because of myocardial infarction. Two multimarker panels were applied (Proximity Extension Assay [Olink Bioscience], Multiple Reaction Monitoring mass spectrometry). Lasso analysis (penalized logistic regression), multiple testing-corrected Mann-Whitney tests and Cox regressions were used to assess sex-differences in the concentrations of these biomarkers and their implications on all-cause mortality and major adverse events (median follow-up up to 6.6 years).

Results
Biomarkers provided a very high discrimination between both sexes, when considered simultaneously (c-statistics 0.972). Compared to women, men had higher concentrations of six biomarkers with the most pronounced differences seen for those reflecting atherogenesis, myocardial necrosis and metabolism. Women had higher concentrations of 14 biomarkers with the most pronounced differences seen for those reflecting activation of the renin-angiotensin-aldosterone axis, inflammation and for adipokines. There were no major variations between sexes in the associations of these biomarkers with outcome.

Conclusions
Severable sex-differences exist in the expression of biomarkers in patients with myocardial infarction. While these differences had no impact on outcome, our data suggest the presence of various sex-related pathways involved in the development of coronary atherosclerosis, the progression to plaque rupture and acute myocardial damage, with a greater heterogeneity in women.
Polypharmacy among people living with type 2 diabetes mellitus in rural communes in Vietnam
Authors: Thi Bui Dieu Huyen , Nguyen Bai Xuan , Truong Dat Cong , Meyrowitsch Dan Wolf , Søndergaard Jens , Gammeltoft Tine , Bygbjerg Ib Christian , Jannie Nielsen 
Published: April 2021

Objectives
People with diabetes are at high risk of polypharmacy owing to complex treatment of diabetes and comorbidities. Polypharmacy is associated with increased risk of adverse reactions and decreased compliance. Therefore, the objectives of this study were to assess polypharmacy in people with type 2 diabetes (T2D) and associated diabetes-related factors in rural areas in Vietnam.

Method
People with T2D (n = 806) who had received treatment for diabetes at a district hospital were invited to participate in a questionnaire-based cross-sectional survey. Polypharmacy was defined as ≥5 types of medicine and assessed as a) prescription medicine and non-prescription/over the counter (OTC) medicine and b) prescription medicine and non-prescription/OTC, herbal and traditional medicine, and dietary supplement. Multiple logistic regression was used to investigate the association between polypharmacy and diabetes specific factors: duration, comorbidities and diabetes-related distress.

Results
Of the people with T2D, 7.8% had a medicine use corresponding to polypharmacy (prescription medicine and non-prescription/OTC), and 40.8% when herbal and traditional medicine, and dietary supplement were included. Mean number of medicine intake (all types of medicines and supplements) were 3.8±1.5. The odd ratios (ORs) of polypharmacy (medicine and supplements) increased with diabetes duration (<1–5 years OR = 1.66; 95%CI: 1.09–2.53 and >5 years OR = 1.74; 95%CI: 1.14–2.64 as compared to ≤1-year duration of diabetes), number of comorbidities (1–2 comorbidities: OR = 2.0; 95%CI: 1.18–3.42; ≥3 comorbidities: OR = 2.63;95%CI: 1.50–4.61 as compared to no comorbidities), and suffering from diabetes-related distress (OR = 1.49; 95%CI: 1.11–2.01) as compared to those without distress.

Conclusions
In rural northern Vietnam, persons with longer duration of T2D, higher number of comorbidities and diabetes-related stress have higher odds of having a medicine use corresponding to polypharmacy. A high proportion of people with T2D supplement their prescription, non-prescription/OTC medicine with herbal and traditional medicine and dietary supplements.
Corneal transplantation activity in Catalonia, Spain, from 2011 to 2018: Evolution of indications and surgical techniques
Authors: Sabater-Cruz Noelia , Figueras-Roca Marc , Padró-Pitarch Lydia , Tort Jaume , Casaroli-Marano Ricardo P. 
Published: April 2021

PurposeTo report corneal transplant activity carried out in Catalonia (Spain) and the evolving indications for keratoplasty over an 8-year period.MethodsAnnual reports from the Catalan Transplant Organization, Spain, on corneal graft indications and techniques from 2011 to 2018 were reviewed.ResultsA total of 9457 keratoplasties were performed in Catalonia, from January 2011 to December 2018. The most frequent indications were bullous keratopathy (BK; 20.5%), Fuchs endothelial dystrophy (FED; 17.9%), re-graft (13.7%), and keratoconus (11.3%). Penetrating keratoplasty (PKP) accounted for 63.4% of all performed keratoplasties. Since the introduction of eye bank precut tissue for Descemet stripping automated endothelial keratoplasty (DSAEK) in 2013 and for Descemet membrane endothelial keratoplasty (DMEK) in 2017 the number of endothelial keratoplasties has drastically increased. An increasing trend of posterior lamellar techniques over the total of keratoplasties was found (p<0.001). Endothelial keratoplasties for different endothelial diseases indications (BK, FED, and re-graft), also showed and increasing trend (p<0.001). DMEK is the technique with the highest increase (statistically significantly different from linearity) over other endothelial keratoplasties in FED (p<0.001) but not in BK (p = 0.67) or re-grafts (p = 0.067).ConclusionEndothelial diseases represented the top indication for keratoplasty over the 8-year period. PKP is still the most used technique in Catalonia, but endothelial keratoplasties and especially DMEK showed a significant increasing trend over the last years. This is congruent with the main rationale nowadays for keratoplasties: to customize and transplant as less tissue as possible. Therefore, the availability of precut tissue could have definitely enforced such approach.
Modelling of Quadratic-Surface Sludge Digesters by Smoothed Particle Hydrodynamics (SPH) – Finite Element (FE) Methods
Authors: Tota-Maharaj Kiran , Nounu Ghassan , Ramroop Navin 
Published: April 2021

Abstract
The quadric-surfaced sludge digester (QSD), also known as the egg-shaped sludge digester, has proven its advantages over traditional cylindrical digesters recently. A reduction in operational cost is the dominant factor. Its shell can be described as a revolution of a parabola with the apex and base being either tapered or spherical. This shape provides a surface free of discontinuities, which is advantageous regarding the efficiency during mixing. Since the shape does not produce areas of inactive fluid motion within the tank, sludge settlement and an eventual grit build-up are avoided. The stresses developed in the shell of the sludge digester, vary along the meridian and equatorial diameters. A non-dimensional parameter, ξ, defines the height-to-diameter aspect ratio which is used to delineate the parametric boundary conditions of the shell’s surface. Three groups of analyses were conducted to determine the orthogonal stresses in the shell of the QSD. The first-principles numerical models ran reasonably quickly, and many simulations were made during the study. The results showed that they were in within the range 5.34% to 7.2% to 2D FEA results. The 3D FEA simulation results were within the range of 8.3% to 9.2% to those from the MATLAB time-history models. This is a good indicator that the first principles numerical models are an excellent time-saving method to predict the behaviour of the QSD under seismic excitation. Upon examining the criteria for the design, analysing the results for the 2D FEA simulations showed that the fill height is not a significant variable with sloshing however the 3D FEA showed that the hydrostatic pressure is a significant variable. With the maximum tensile stress of the 3D-printed Acrylonitrile Butadiene Styrene (ABS)-a common thermoplastic polymer typically used for injection molding applications, being 24.4 MPa, the overall maximum stress of 5.45 MPa, the material can be a viable option for the use of QSD construction in small island developing states (SIDS).
A Bayesian mixture model for changepoint estimation using ordinal predictors
Authors: Roberts Emily , Zhao Lili 
Published: April 2021

Abstract
In regression models, predictor variables with inherent ordering, such ECOG performance status or novel biomarker expression levels, are commonly seen in medical settings. Statistically, it may be difficult to determine the functional form of an ordinal predictor variable. Often, such a variable is dichotomized based on whether it is above or below a certain cutoff. Other methods conveniently treat the ordinal predictor as a continuous variable and assume a linear relationship with the outcome. However, arbitrarily choosing a method may lead to inaccurate inference and treatment. In this paper, we propose a Bayesian mixture model to consider both dichotomous and linear forms for the variable. This allows for simultaneous assessment of the appropriate form of the predictor in regression models by considering the presence of a changepoint through the lens of a threshold detection problem. This method is applicable to continuous, binary, and survival outcomes, and it is easily amenable to penalized regression. We evaluated the proposed method using simulation studies and apply it to two real datasets. We provide JAGS code for easy implementation.
Time Is Running. Ancient Greek Chronography and the Ancient Near East
Authors: Kellner Angelika 
Published: April 2021

AbstractThe article explores the question whether there was a possible dialogue between ancient Greek and Mesopotamian chronography. This is an interesting albeit challenging subject due to the fragmentary preservation of the Greek texts. The idea that cuneiform tablets might have influenced the development of the genre in Greece lingers in the background without having been the subject of detailed discussion. Notably the Neo-Assyrianlimmulist has been suggested as a possible blueprint for the Athenian archon list. In order to examine this topic further, a thorough analysis of ancient Greek chronography starting in the second half of the fifth century BC, when eponymous dates in various literary compositions begin to appear, is required. A close examination of the fragmentary evidence shows how difficult it is to trace the supposed annalistic style in the local histories of Athens (Atthides). In the Neo-Assyrian Empire, the eponymouslimmuofficials served as the chronological backbone, but there remains a huge time gap between the seventh century cuneiform manuscripts and the Athenian archon list from the fifth century. A comparison of the Neo-Assyrian Eponymous Chronicles with the preserved Greek chronographic traditions in Eusebius’ chronicle (fourth century AD) shows that the similarity is mainly confined to an abbreviated style, as the entries clearly point to the different cultural and political settings. Apart from the Neo-Assyrian sources, the Neo- and Late-Babylonian chronicles deserve further attention in the present inquiry. Looking for a connection with ancient Greek chronography in the fifth century, the lack of wholly preserved texts on both sides in the corresponding time constitutes an unsurmountable obstacle. Presenting and scrutinising the textual evidence both for ancient Greek and for Mesopotamian chronography enables an improved understanding of similarities and differences alike. To exemplify this point, Greek and Akkadian temple histories serve as test cases.
Early menarche is associated with insulin-resistance and non-alcoholic fatty liver disease in adolescents with obesity
Authors: Di Sessa Anna , Grandone Anna , Marzuillo Pierluigi , Umano Giuseppina Rosaria , Cirillo Grazia , Miraglia del Giudice Emanuele 
Published: April 2021

Abstract

Objectives
Recent evidence linked early menarche to a higher risk of insulin-resistance (IR) and nonalcoholic fatty liver disease (NAFLD) in adulthood. We aimed to evaluate the impact of early menarche on glucose derangements and NAFLD in a sample of Italian adolescents with obesity.

Methods
Anthropometric and biochemical evaluations were conducted in all the enrolled 318 obese patients (mean age 12.31 ± 2.95 years). NAFLD was defined by the presence of ultrasound detected liver steatosis and/or alanine transaminase (ALT) levels >40 IU/L.

Results
Patients with early menarche showed both higher homeostasis model assessment of insulin-resistance (HOMA-IR) (p=0.008) and ALT (p=0.02) values, an increased prevalence of NAFLD (p=0.001), and lower Matsuda and Insulinogenic Index (IGI) values than the other obese patients. The association between early menarche and both ALT and Matsuda Index remained significant in General Linear Models (GLMs) in which respectively body mass index standard deviation score (BMI-SDS) and Matsuda Index, and BMI-SDS were included as covariates. Patients with early menarche also showed a higher risk of both HOMA-IR>3 (OR 1.69, CI 1.05–2.70, p=0.02) and NAFLD (OR 1.10, CI 1.01–1.21, p=0.03).

Conclusions
Girls with obesity presenting early menarche showed higher HOMA-IR levels, lower Matsuda Index and IGI values, and higher risk of NAFLD compared to girls without early menarche.