bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal timing of anti-PD-1 antibody combined with chemotherapy administration in patients with NSCLC
Authors: Huo Yachang , Wang Dan , Yang Shuangning , Xu Yujie , Qin Guohui , Zhao Chenhui , Lei Qingyang , Zhao Qitai , Liu Yaqing , Guo Kaiyuan , Ouyang Songyun , Sun Ting , Wang Hongmin , Fan Feifei , Han Na , Liu Hong , Chen Hongjie , Miao Lijun , Liu Li , Duan Yuqing , Lv Wei , Liu Lihua , Zhang Zhixin , Cang Shundong , Wang Liping , Zhang Yi 
Published: December 2024

BackgroundAnti-programmed cell death 1 (PD-1) antibody combined with chemotherapy simultaneously is regarded as the standard treatment for patients with advanced non-small cell lung cancer (NSCLC) by current clinical guidelines. Different immune statuses induced by chemotherapy considerably affect the synergistic effects of the chemo-anti-PD-1 combination. Therefore, it is necessary to determine the optimal timing of combination treatment administration.MethodsThe dynamic immune status induced by chemotherapy was observed in paired peripheral blood samples of patients with NSCLC using flow cytometry and RNA sequencing. Ex vivo studies and metastatic lung carcinoma mouse models were used to evaluate immune activity and explore the optimal combination timing. A multicenter prospective clinical study of 170 patients with advanced NSCLC was performed to assess clinical responses, and systemic immunity was assessed using omics approaches.ResultsPD-1 expression on CD8+T cells was downregulated on day 1 (D1) and D2, but recovered on D3 after chemotherapy administration, which is regulated by the calcium influx-P65 signaling pathway. Programmed cell death 1 ligand 1 expression in myeloid-derived suppressor cells was markedly reduced on D3. RNA sequencing analysis showed that T-cell function began to gradually recover on D3 rather than on D1. In addition, ex vivo and in vivo studies have shown that anti-PD-1 treatment on D3 after chemotherapy may enhance the antitumor response and considerably inhibit tumor growth. Finally, in clinical practice, a 3-day-delay sequential combination enhanced the objective response rate (ORR, 68%) and disease control rate (DCR, 98%) compared with the simultaneous combination (ORR=37%; DCR=81%), and prolonged progression-free survival to a greater extent than the simultaneous combination. The new T-cell receptor clones were effectively expanded, and CD8+T-cell activity was similarly recovered.ConclusionsA 3-day-delay sequential combination might increase antitumor responses and clinical benefits compared with the simultaneous combination.
Decision Support for Managers: Using Algorithms to Optimize the Student Management Decision-Making Process
Authors: Li Hongli , Liu Yang , Wang Hui 
Published: December 2024

Distant learning revealed the requirement for evolution in education to adapt to social distinctions and modern technology. Teachers are assessed on their ability to teach as well as motivated and their students are influenced by a variety of factors. Enhancing comprehension and boosting student education and educational success are receiving more attention. To strengthen the processes of decision-making by streamlining data mining tasks, this research proposes an algorithmic-driven decision support system (Algo-DSS) technique. Initially, we gathered a graduate-level academic sample with a variety of attributes. Uniform Manifold Approximation and Projection (UMAP) and Principal Component analysis (PCA) techniques are used to extract the particular characteristics regarding dimensionality reduction. Moreover, the suggested structure for the feature extraction procedures encompasses the clustering methodology. This paper presents the unique swarm-inspired dynamic catboost (SIDCatBoost) approach for enhanced classification performance. The effective feature subsets are chosen using the swarm approach which is known as rock hyraxes optimization (RHO) and then fed into the catboost technique. Employing the suggested framework, the issue of mining academic information has been carefully investigated with the aim of evaluating student performance. In addition to demonstrating a significant boost in performance through the use of a technique for choosing discriminative data attributes, the task of classification was completed with excellent results. Algo-DSS has the potential to be a helpful tool in educational settings, especially for enhancing processes of decision-making, as demonstrated by the conducted study.
N-Gram-Based Translation Consistency Detection Method for Cultural External Propaganda Terms
Authors: Liu Dongni 
Published: December 2024

Some terms may contain multiple components, each part has its own specific meaning, and the overall meaning may have new changes, which increases the difficulty of translation. Therefore, there are problems such as poor test results in the consistency test of translation of cultural external propaganda terms. To this end, this paper designs a translation consistency detection method for cultural external promotion terms based on N-gram. The distance function is used to characterize the translation data vector of cultural external propaganda terms, the characteristics of the translation data of cultural external propaganda terms are determined through the word frequency statistical method, and the correlation between the translation data of cultural external propaganda terms is analyzed with the help of Laplace smoothing method, so as to realize the relationship analysis of the translation data of cultural external propaganda terms. Set the consistency detection rules for the translation of cultural external publicity terms, including: functional dependency, conditional functional dependence, inclusion dependency, negative constraints, time constraints, Fixing rules, and numerical rules. Based on these rule settings, the translation of cultural external publicity terms is clarified. Design the overall structure of the translation consistency detection of cultural external promotion terms based on N-gram, that is, dictionary generation module, data processing module, translation data generation module, and translation data filtering module. According to the functions of different modules, the translation data of cultural external promotion terms are extracted, and a translation consistency detection model of cultural external promotion terms is designed based on N-gram, input the extracted translation data of cultural external promotion terms, and complete the consistency detection. Experimental results show that this method can effectively improve the translation consistency detection results of cultural external propaganda terms.
Antiplatelet Effects of a Combination of Sappan Wood (Caesalpinia sappan L.) and Red Ginger (Zingiber officinale var. Rubrum) Extracts in a High‐Fat Diet‐Induced Rat Model
Authors: Puteri Meidi Utami , Afifah Nur , Mathriul Anisa Qisti , Wicaksono Farhan Mahmudi , Sugiarti Mellynia Tri , Izzatinisa Raihana , Kato Mitsuyasu , Saputri Fadlina Chany 
Published: December 2024

Background: Antithrombotic medications, including antiplatelet agents, are standard treatments for patients with hyperlipidemia who have a high risk of developing cardiovascular disease (CVD). The ongoing exploration of new antiplatelet agents with minimal bleeding effects is crucial, including the investigation of potential compounds derived from natural products. This study intended to evaluate the antiplatelet effects of a combined extract of sappan wood (Caesalpinia sappan L.) and red ginger (Zingiber officinale var. Rubrum) in high‐fat diet‐(HFD)‐induced rats.Methods: Eighteen male Wistar rats were grouped into six groups (n = 3): control, negative, positive, and three groups of various combinations of extracts. All groups, excluding the control group, were fed an HFD for 8 weeks. In the eighth week, the control and negative groups were given carboxyl methyl cellulose (CMC) 0.5%, the positive control group was administered aspirin, and the other three groups were administered the combination extract of sappan wood and red ginger at various doses for 2 weeks. Blood samples were collected to assess the levels of hyperlipidemia and platelet hyperactivity markers by enzyme‐linked immunosorbent assay (ELISA). The physiological effects of platelet hyperactivity were evaluated using the tail bleeding assay.Results: HFD‐induced hypertriglyceridemia and hypercholesterolemia synergistically enhanced platelet hyperactivity after 8 weeks of induction. Interestingly, administration of all doses of the combined extract for 2 weeks significantly decreased the platelet activation markers P‐selectin, RANTES, and PCSK9 in a dose‐dependent manner compared with the negative control. In addition, the combination of sappan wood and red ginger extract at dose 3 (sappan wood:red ginger: 200:800 mg/200 bw/day) significantly extended the bleeding time of rats (p < 0.05) compared to the negative control.Conclusion: Collectively, our results highlight the antiplatelet effect of a combination of sappan wood and red ginger extract in HFD‐fed rats.
Multilevel Mediators on the Associations of Neighborhood Social Environmental Factors and Severity of Metabolic Syndrome: The Jackson Heart Study
Authors: Moniruzzaman Mohammad , Reid Lauren A. , Jones Kelly K. , Zenk Shannon N. , Vega Gloria L. , Grundy Scott M. , Sims Mario , Powell‐Wiley Tiffany M. , Tamura Kosuke 
Published: December 2024

Background
Neighborhood characteristics serve as risk factors for metabolic syndrome (MetS). However, the intermediary factors linking this relationship remain understudied. Thus, we investigated the sex‐specific mediating role of C‐reactive protein, physical activity (PA), and perceived stress in the associations of perceived neighborhood social environment (PNSE) with MetS severity among Black adults.

Methods and Results

This cross‐sectional study included 3185 adults (64% women) from exam 1 (2000–2004) of the Jackson Heart Study. MetS severity
Z
scores were calculated based on the Adult Treatment Panel III criteria formula. PNSE included neighborhood violence, problems, and social cohesion. Men and women were analyzed separately. A bootstrap resampling technique with 95% bias‐corrected CI (95% BC CI) was used to evaluate whether C‐reactive protein, PA, and perceived stress mediated the association between each PNSE and MetS severity, adjusting for covariates. All PNSE factors were directly related to MetS severity in women but not in men. In women, neighborhood problems were indirectly associated with MetS severity mediated through PA (β=0.02 [95% BC CI, 0.00–0.05]). In men, neighborhood violence, problems, and social cohesion were indirectly associated with MetS severity mediated through PA (β=0.05 [95% BC CI, 0.01–0.10]; β=0.03 [95% BC CI, 0.00–0.06]; and β=−0.04 [95% BC CI, −0.09 to −0.01], respectively). Neither C‐reactive protein nor perceived stress mediated such associations in either women or men.

Conclusions
All PNSEs (violence, problems, and social cohesion) were directly related to MetS severity in women only. PA mediated the relationship between each PNSE and MetS in a sex‐specific manner. Efforts focusing on local conditions are needed to better understand why such disparities exist for at‐risk minoritized groups.
Susanna Clarke’s Cautionary Tale of Re-enchantment
Authors: Clarkson Joy Marie 
Published: December 2024

Abstract
This article offers a reading of Susannah Clarke’s 2020 award-winning novel Piranesi in relation to theories of enchantment. Clarke’s novel has often been read as an affirmation of re-enchantment, but this article will show that Piranesi acts more as a cautionary tale, pointing out the inherent tensions in projects of re-enchantment which often reinforce rather than dissolve the boundaries between inner and outer world which characterize disenchantment. Clarke’s critique of re-enchantment is largely indebted to Owen Barfield’s distinctive and complex account of modernity through his notion of the evolution of consciousness and his affirmation of anthroposophy, which has often been overlooked in contemporary scholarship of enchantment. Thus, this article both brings to light Barfield’s influence on Clarke, but also highlights how Clarke and Barfield might be drawn upon as resources for diagnosing and describing the phenomenon of disenchantment, and even perhaps constructing alternative modernities.
Toward a Holistic and Integrative Pedagogy
Authors: Coulter Dale , Yong Amos 
Published: December 2024

Abstract
We wish to express our thanks to our interlocutors and to the editors of Pneuma for facilitating this exchange as part of an issue on higher education within Pentecostalism. It is a humbling experience to have our work digested by seasoned administrators long at work in pentecostal higher educational spheres who share with us the calling and task of forging a Christ-formed and Spirit-infused life of the mind. Maybe the best way to hand off our dialogue is simply to reiterate Mark Cartledge’s point, in his lead essay in this issue of the journal, of the attempt to capture in the phrase “head, heart, and hands” a holistic and transformational approach to personal and spiritual formation. Come Holy Spirit, inspire our collaborative conversation and educational efforts.
Sighs and Signs of the Spirit
Authors: Asamoah-Gyadu Kwabena 
Published: December 2024

Abstract
This article explores the importance of Spirit-empowered scholarship for theological education. It argues that given the overwhelming presence of Christianity in such non-Western contexts as Africa and the options in these new heartlands of Christianity for theological scholarship and education that accounts for the experience of the Spirit, it is appropriate for theological education to pay attention to these developments. This is imperative for the African context in which Pentecostalism with its emphasis on the experience of the Spirit is influencing virtually every area of Christian life including what is meant by theology and theological education.
On Sensibilities and Shamsy’s “Rediscovering”
Authors: Rafudeen Auwais 
Published: December 2024

Abstract
While Shamsy’s Rediscovering the Islamic Classics importantly traces the events and individuals involved in the rise of print culture in the Arab world, particularly in an Egyptian context, and, even more tellingly, throws light on how Muslim reformers used this culture to reintroduce long forgotten classical Islamic works – a process which they deemed crucial in view of what they felt was a very problematic postclassical status quo and through which they substantially transformed the then hegemonic intellectual tradition – one is left with a lingering sense that a vital dimension of this transformation, namely the underlying change in sensibilities with which this transformation is associated, needs to be more thoroughly scrutinised. These sensibilities speak to new notions of time, the nature of knowledge and the purpose of life engendered by modernity, which cannot be extricated from the intellectual transformations being discussed.
“God Is Not in the Habit”
Authors: Africa Obakeng 
Published: December 2024

Abstract
This article examines Steve Biko’s theology of human and divine agency, centred on his remark, “God is not in the habit of coming down from heaven to solve people’s problems on earth.” Engaging John D. Caputo’s radical theology and its relational model of the chiasm, it explores the interdependence of divine insistence and human responsibility. Highlighting Biko’s critique of apartheid-era Christianity and his call for Black self-liberation, the article emphasises his theology as a call to responsibility. The dialogue with Caputo’s framework opens a deeper understanding of Biko’s theological vision, offering a relational approach to agency that redefines divine-human interaction in the struggle for justice and liberation.
L’interprétation ricœurienne de Fichte : une lecture commune du primat kantien de la raison pratique
Authors: Renzi Angela 
Published: December 2024

Résumé
Cette contribution se propose d’établir un lien critique entre Ricœur et Fichte afin de déterminer deux objectifs. Le premier objectif consiste à analyser la réception complexe de Fichte par Ricœur, qui constitue à mon avis une approche interprétative intéressante de la philosophie transcendantale. Ricœur souligne la richesse inexplorée de la philosophie fichtéenne, qui se trouve précisément dans la philosophie transcendantale et dans le sentiment d’être en tant qu’affirmation éthique et point de départ de la réflexion elle-même et affirme vouloir rechercher une origine éthique. Le second objectif est souligner la fécondité de l’interprétation de Ricœur, qui oriente la lecture de la morale kantienne et la primauté de la raison pratique. On peut identifier la même direction critique entre les deux philosophes, dans laquelle la vision du sujet est orientée vers une perspective éthique intersubjective et intérieure.
Je est une autre
Authors: Muller Justine 
Published: December 2024

Résumé
Cet article s’interroge sur la façon dont le roman autobiographique L’Invitée traduit, par le biais du personnage de Françoise, la tension de Beauvoir au départ de sa relation avec Sartre entre sa tendance à la dépendance et sa volonté d’acquérir une autonomie personnelle et littéraire. La consécration de cette autonomie se marque par le déploiement d’une esthétique qui ne repose pas sur celle de Sartre, mais qui s’inspire des techniques de divers auteurs anglo-saxons afin de dévoiler une subjectivité féminine.
La philosophie morale comme exercice de démystification dans L’Amérique au jour le jour
Authors: Tribotté Julien 
Published: December 2024

Résumé
L’Amérique au jour le jour de Simone de Beauvoir est un ouvrage philosophique important, mais souvent négligé par la critique anglaise en raison de choix de traduction. Les premières traductions en anglais ont occulté la dette de Beauvoir à l’égard des écrits de Richard Wright ainsi que le concept de « mystification », au cœur de son cadre philosophique. Cet article examine l’effort de Beauvoir pour dévoiler les réalités sociales de l’Amérique depuis le point de vue d’une personne issue d’un autre pays. En analysant la cohérence du livre de Beauvoir et en soulignant l’importance de la « mystification », cette étude vise à élucider son projet novateur de rendre la philosophie morale accessible par le biais de l’expérience vécue.
Tropical cyclone genesis potential using a ventilated potential intensity
Authors: Chavas Daniel R. , Camargo Suzana J. , Tippett Michael K. 
Published: December 2024

Abstract
Genesis potential indices (GPIs) are widely used to understand the climatology of tropical cyclones (TCs). However, the sign of projected future changes depends on how they incorporate environmental moisture. Recent theory combines potential intensity and mid-tropospheric moisture into a single quantity called the ventilated potential intensity, which removes this ambiguity. This work proposes a new GPI (GPIv) that is proportional to the product of the ventilated potential intensity and the absolute vorticity raised to a power. This power is estimated to be approximately 5 by fitting observed tropical cyclone best-track and ECMWF Reanalysis v5 (ERA5) data. Fitting the model with separate exponents yields nearly identical values, indicating that their product likely constitutes a single joint parameter. Likewise, results are nearly identical for a Poisson model as for the power law. GPIv performs comparably well to existing indices in reproducing the climatological distribution of tropical cyclone genesis and its covariability with El Niño-Southern Oscillation, while only requiring a single fitting exponent. When applied to Coupled Model Intercomparison Project Phase 6 (CMIP6) projections, GPIv predicts that environments globally will become gradually more favorable for TC genesis with warming, consistent with prior work based on the normalized entropy deficit, though significant changes emerge only at higher latitudes under relatively strong warming. GPIv helps resolve the debate over the treatment of the moisture term and its implication for changes in TC genesis favorability with warming, and its clearer physical interpretation may offer a step forward towards a theory for genesis across climate states.
Does shockwave therapy lead to better pain and function than sham over 12 weeks in people with insertional Achilles tendinopathy? A randomised controlled trial
Authors: Alsulaimani Baraa , Perraton Luke , Vallance Patrick , Powers Tim , Malliaras Peter 
Published: December 2024

Objectives To investigate the efficacy of adding radial extracorporeal shockwave therapy or sham to exercise for people with insertional Achilles tendinopathy. Design A two-armed, parallel-group, explanatory, single-centre, randomised controlled trial within a superiority framework. Setting Private clinic. Participants People diagnosed with insertional Achilles tendinopathy who were over 18 years old with a symptom duration of greater than 3 months. Intervention A total of 76 people were randomly assigned (one-to-one ratio) to receive three sessions of radial extracorporeal shockwave therapy or sham to the affected side (or most affected side if bilateral). All participants received identical education and exercise. Outcome measures The primary outcome was the Victorian Institute of Sports Assessment – Achilles questionnaire. Measures were recorded at baseline, 6 weeks and 12 weeks. Results At 12 weeks, the questionnaire data were available for 37 people (96%) in the radial extracorporeal shockwave therapy group and 36 people (95%) in the sham group. For the primary outcome, we found no evidence for between-group differences at 6 (3, 95% confidence interval −4.6–10.5) or 12 weeks (4.6, 95% confidence interval −2.5–11.6). There was also no evidence for a between-group difference for any secondary outcome measures at either 6 or 12 weeks ( p > .05). No serious adverse events were reported. Conclusion The addition of radial extracorporeal shockwave therapy to exercise and education did not lead to improvements in pain, function or other outcomes compared to sham at 6 or 12 weeks among people with insertional Achilles tendinopathy. ANZCTR Reg No: ACTRN12620000035921