bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Serum Lipid Parameters and Cognitive Performance in Older Adults
Authors: Lee Jaeho , Lee Sohyae , Min Jin-young , Min Kyoung-bok 
Published: November 2021

(1) Background: Previous studies have suggested the association between lipid profiles and cognitive function in older adults. However, they generated inconsistent results. We aim to determine the relationship between lipid profiles and cognitive performance in older adults. (2) Methods: We used the 2011–2014 National Health and Nutrition Examination Survey. This study included 2215 participants who were aged more than 60 years old and free of coronary heart disease or stroke. Lipid profiles included total cholesterol (TC), low density lipid cholesterol (LDL), high density lipid cholesterol (HDL), and triglyceride (TG). Cognitive function was assessed using the digit symbol substitution test (DSST). (3) Results: Positive correlations of DSST were observed with TC (r = 0.111; p < 0.0001), HDL (r = 0.127; p < 0.0001), and LDL (r = 0.107; p = 0.0005). However, there was no significant relationship between TG and DSST. A one-unit increase in HDL was associated with an increase in DSST score (beta coefficient: 0.036; p = 0.018); but the association was not significant for LDL, TG, and TC. In the categorical analysis, the high HDL group had a higher DSST score than the low HDL group (beta = 3.113; p < 0.0001) and the low TG group was more likely to show a lower DSST score than the high TC group (beta = −1.837; p = 0.0461). However, LDL and TC showed no statistically significant associations. Moreover, HDL was only associated with a 0.701 times increased risk of cognitive impairment (95% CI = 0.523–0.938) in the logistic regression analysis. (4) Conclusions: Higher blood concentrations of HDL levels were positively associated with DSST scores in older adults. We suggest that the high levels of HDL may be a protective factor against cognitive impairment.
JUDICIAL REVIEW SATU ATAP DI MAHKAMAH KONSTITUSI SEBAGAI REFLEKSI TERHADAP PROBLEMATIKA DAN TANTANGAN KEKUASAAN KEHAKIMAN DI INDONESIA
Authors: Ali Hofi Moh. 
Published: November 2021

Judicial review merupakan suatu upaya hukum agar dapat keluar dari peroalan regulasi yang dihasilkan pembentuk uu dengan kualitas rendah. namun demikian, penyelenggaraan judicial review pada praktiknya selama ini dapat memunculkan suatu persoalan hukum. Penyebabnya di antaranya adalah pembagian kewenangan dalam praktik judicial review oleh MK dan MA untuk melakukan judicial review. Disamping hal di atas, beberapa alasan pengujian satu atap di Mahkamah Konstitusi didasari beberapa alasan, di antaranya mengurungi beban menumpuk di Mahkamah Agung mengingat MA tidak hanya sekedar menguji regulasi dibawah uu, kasasi, peninjauan kembali kasus pidana dan perdata serta TUN juga menjadi bagian dari kewenangan MA yang tidak terpisahkan, kepastian hukum serta keadilan bagi masyarakat, efisiensi dan efektifitas dapat diwujudkan bila dilakukan dalam satu atap di MK. Praktik judicial review di Mahkamah Konstitusi sangat terbuka bila di bandingkan MA. Karenanya judicial review satu di MK Urgent untuk dilaksanakan. Tulisan ini mengkaji dengan konkrit persoalan dualisme judicial review dalam perspektif negara hukum serta ugensi judicial review satu pintu di MK sebagai solusi atas problematika di atas.
Toward the Shari'ah Paradigm of Islamic Economics
Authors: Arif Muhammad 
Published: November 2021

I. INTRODUCTION -THE MAJOR CRITICS OFISLAMIC ECONOMICS: This paper attempts to respond to the critics who, on various grounds, oppose the development of Islamic economics. The author feels that a scientific response to these critics is the responsibility of the Islamic economists. It is believed that such a response would be educational for the critics and their followers. It would enable them not only to understand the scientific nature of Islamic economics but would also allow them to appreciate that the development of the Shari'ah paradigm ofislamic economics is, in fact, the beginningofascientific revolution in economics. Given the bases of their arguments, these critics of Islamic economics can be classified into the following three schools of thought.
1) The Adjusted Capitalism School:
According to this school the fundamental principles of the Islamic economic system are the same as those of capitalism. In support of this assertion they point out that like capitalism, Islam also allows the right to private property, free enterprise, and market economy. They, however, acknowledge that certain adjustments need to be made in capitalism to bring it in conformity with Islamic principles. They hold that these adjustments should be made according to Islam's distinction between Haram and Halal, and Islam's teachings in financial and fiscal areas; namely, riba and zakat. According to this school, if these areas of capitalism are adjusted according to Islamic requirements, then the adjusted form of capitalism will be nothing but the Islamic economic system. Thus this school holds that the conventional economic theory, with only a few adjustments, is fully capable of generating the Islamic economic system. Hence, they see no scientific justification for the development of Islamic economics toward the creation and establish­ment of an Islamic economic system ...
Condição imigrante
Authors: Prates Lubi , Miguel Fernanda 
Published: November 2021

Nesta entrevista, concedida em 2020 pela poeta Lubi Prates ao Grupo de Estudos em Literatura, Arte e Cultura (UFVJM/CNPq), a escritora fala sobre o momento presente da Pandemia da Covid-19 no Brasil, sobre a relação de seus versos com a questão do pertencimento e o permanente processo de reconhecimento, na ideia de tornar-se negra em diáspora, uma desconhecida ou uma eterna imigrante, e, sobretudo, sobre como planeja a liberdade através da poesia.
Clinical phenotype, diagnostics, strategy of hypophosphatasia therapy due to <i>ALPL</i> gene mutations in pediatric and adult patients
Authors: Leviashvili Zh. G. , Savenkova N. D. 
Published: November 2021

Hypophosphatasia (HPP) ORPHA 436 is a rare disease with an autosomal recessive/autosomal dominant mode of inheritance due to mutations in the ALPL gene mapped on chromosome 1p36.12, encoding a nonspecific tissue isoenzyme alkaline phosphate (TNSALP). Currently, there are more than 400 known mutations in the ALPL gene. HPF is characterized by variability of manifestations from a mild course with minor damage to bones and teeth to severe forms with damage to the nervous system, lungs, and kidneys. In different countries, data on the prevalence of HPP differ, the average prevalence of severe forms is ~ 3.3 cases per 1 million newborns. In Europe, the prevalence of severe forms is 1: 300000 and moderately severe 1: 63701. The prevalence of mild HPP is thought to be much higher. The expected prevalence of severe forms in the Russian Federation is 1: 100000. GPP is diagnosed in patients of any age (with manifestation in utero, in childhood, or in adulthood).HPP is an orphan disease, occurring in patients with damage to many organs and systems: bone (osteoporosis, rickets, fractures, growth retardation), lungs (hypoplasia of the lungs, respiratory failure), central nervous system (vitamin B-dependent convulsions), kidney (calciuria, nephrocalcinosis, chronic kidney disease). In the absence of timely enzyme replacement therapy for severe forms of HPP, characterized by a progressive course, the prognosis for life is unfavorable. The only effective treatment for patients is enzyme replacement therapy in combination with symptomatic therapy. The article presents the features of the phenotype and genotype, clinical forms of HPP (perinatal severe, lethal, perinatal benign, infant, pediatric, adult, and odontohypophosphatasia), methods of early diagnosis, the strategy of pathogenetic enzyme replacement therapy of severe and moderate forms in pediatric and adult patients. In the absence of a timely diagnosis, pathogenetic treatment of GFF, there is a high risk of progression with disability and death.
Predictor significance of β<sub>2</sub>-microglobulinuria in determining the risk of cardiovascular complications in patients with chronic ischemic heart disease
Authors: Levitskaya E. S. , Batiushin M. M. , Khripun A. V. 
Published: November 2021

BACKGROUND. The relevance of identifying new biomarkers of the cardio-renal syndrome in patients with coronary heart disease is beyond doubt. It is promising to study the indicators of tubular dysfunctions as predictors of the risk of cardiovascular complications in patients without primary kidney pathology.THE AIM. Analysis of the effect of β2-microglobulinuria on the prognosis of cardiovascular complications in patients with chronic ischemic heart disease in the long-term period after myocardial revascularization.PATIENTS AND METHODS. The study included 90 patients with coronary artery disease and indications for myocardial revascularization. Coronary bypass surgery was performed in 64 people, coronary artery stenting - in 26. Clinical and anamnestic data were collected in all patients, standard laboratory and instrumental diagnostics were performed. In addition, the level of β2-microglobulin (β2-MG) in the first morning portion of urine was determined at different study dates. The endpoint was considered to be the presence of acute forms of coronary heart disease - myocardial infarction and unstable angina. Survival after 5.8 ±0.1 years after myocardial revascularization was 69 %.RESULTS. A positive linear relationship of weak strength was established between the level of diastolic blood pressure (DBP) and β2-MG of urine obtained before myocardial revascularization (r = 0.28, p = 0.03). Moreover, the Kaplan-Meyer survival analysis showed the effect of an increase in β2-MG of urine over 0.2 ng/ml on the risk of AMI in the long-term period after myocardial revascularization (p = 0.025). It was found that an increase in the concentration of β2-MG in urine determined before myocardial revascularization is a statistically significant risk factor for the development of unstable angina in the long-term period after RM (χ2-criterion = 7.17, p = 0.007).CONCLUSION. It has been shown that an increase in the concentration of β2-MG in urine, reflecting the presence of tubular dysfunctions, can be considered as a predictor of an unfavorable cardiovascular prognosis in patients in the long-term period after myocardial revascularization.
The role of bone metabolism regulators sclerotin and osteoprotegerin in the development of cardiovascular complications in the late stages of chronic kidney disease
Authors: Dzgoeva F. U. , Remizov O. V. , Botsieva V. Kh. , Malakhova N. G. , Ikoeva Z. R. , Goloeva V. G. , Gireyeva E. Yu. , Gurina A. E. , Tsallagova L. V. 
Published: November 2021

BACKGROUND. Cardiovascular complications caused by vascular calcification in chronic kidney disease (CKD) are closely related to disorders of bone and mineral metabolism, the mechanisms of which require further study.THE AIM: to clarify the role of the regulatory proteins of bone metabolism of sclerostin and osteoprotegerin in the processes of vascular calcification and the development of cardiovascular complications in CKD.PATIENTS AND METHODS. 110 patients with stage 3-5D CKD (67 men) were examined. Median age is 47.0 (23.0-68.0) years. Osteoprotegerin (OPG), sclerostin, intact parathyroid hormone (IPTG), troponin I in blood serum were determined using commercial kits "Enzyme-linked Immunosorbent Assay Kit for Sclerostin" ("Cloud-Clone Corp.", USA) and commercial kits "ELISA kit" ("Biomedica" (Austria) by enzyme immunoassay (ELISA). Echocardiography with Dopplerography was performed on the device "ALOKA 4000" ("Toshiba", Japan). The left ventricular myocardial mass index (LVMI) and peak systolic blood flow velocity in the aortic arch (Vps, peak systolic velocity) were determined to quantify hemodynamic changes indirectly indicating the state of the aortic vascular wall.RESULTS. Analysis of the ratios of the calculated glomerular filtration rate (EGFR), IMLJ, Vps, OPG, and sclerostin showed that a decrease in excretory kidney function is accompanied by an increase in the concentrations of OPG and sclerostin in the blood serum. At the same time, there is an increase in IMLJ and Vps. During the correlation analysis, it was shown that the level of OPG was positively correlated with the level of sclerostin and negatively with the level of iPTG.CONCLUSION. In our study, we obtained data confirming the interactive interaction between the vascular and bone systems. Morphogenetic proteins-inhibitors of bone metabolism (sclerostin and OPG) play a significant role in the defeat of the cardiovascular system in patients with CKD, as they promotes the development of vascular calcification.
Vitamin D levels in patients with diabetes mellitus in combination with chronic kidney disease
Authors: Lichacheva A. P. , Agranovich N. V. , Klassova A. T. , Anopchenko A. S. , Solovyova E. L. 
Published: November 2021

BACKGROUND. Vitamin D has been known since 1928. The wide range of its metabolic effects paradoxically contrasts with the high prevalence of insufficiency and deficiency in the population of different regions of the world. A number of publications have demonstrated information about the relationship between vitamin D and insulin production by beta cells of the pancreas, as well as the excretory function of the kidneys.THE AIM: to assess the level of vitamin D in patients with diabetes mellitus in combination with chronic kidney disease (CKD).PATIENTS AND METHODS. A questionnaire and a study of the level of 25-hydroxyvitamin D, creatinine, urea, and glucose in the blood were conducted in 117 patients aged 18 to 84 years who gave voluntary consent. All patients were divided into three study groups: group 1 - patients with long-term DM, group 2 - patients with newly diagnosed DM, and 3 - control group. The glomerular filtration rate (GFR) is calculated by the formula CKD-EPI.RESULTS. As a result of the study, it was found that patients with DM, regardless of the duration of its course, were more likely to suffer from vitamin D deficiency, compared with the control group, where D-deficiency and D-deficiency occurred with the same frequency. In addition, patients with DM were more likely to have stage 2-3A CKD, in contrast to the control group, where preserved kidney function prevailed. We also identified and confirmed the direct dependence of GFR on the level of vitamin D in the blood of patients with DM.CONCLUSION. In the patients studied by us, a clear association was found between a lower vitamin D index in the blood serum and the presence of a history of diabetes. They also showed a tendency to decrease the excretory function of the kidneys and the formation of CKD. Consequently, a full-fledged diagnosis of vitamin D-deficient conditions and timely initiated therapy can prevent or at least slow down the progression of CKD in these patients, which will certainly improve their quality of life and reduce the costs of health services for renal replacement therapy and rehabilitation of this group of patients.
Clinical and morphological presentation of C3 glomerulopathy: a single-center study of 60 cases
Authors: Dobronravov V. A. , Karunnaya A. V. 
Published: November 2021

INTRODUCTION. СЗ-glomerulopathy (СЗ-GP) is a spectrum of diseases caused by dysregulation of the alternative complement pathway. The present study was carried out taking into account the limited number of foreign and the absence of original studies in the Russian population.THE AIM. Analysis of clinical and morphological manifestations of СЗ-GP at the time of primary diagnosis.PATIENTS AND METHODS. Retrospective analysis of the etiology, clinical data and morphology of СЗ-GP identified in the period 2006-2021.RESULTS. The study included 60 cases. The average age of patients is 4З±17 years. Nephrotic syndrome was detected in 47 % of patients; in 58 % of cases the estimated glomerular filtration rate was <60 ml/ min/иЗ m2. The dominant morphological pattern was membranoproliferative glomerulonephritis (75% cases). In 2 cases, СЗ-GP debuted with clinical and morphological manifestations of the disease of minimal changes, in which the identification of characteristic electron-dense deposits became obvious when performing a second biopsy. 4 cases had at the onset classical signs of complement-mediated thrombotic microangiopathy (atypical hemolytic uremic syndrome) in combination with C3-GP or its subsequent development.Ultrastructural examination was performed in 40 cases. 8 patients (20%) were diagnosed dense deposit disease, 32 patients - C3-glomerulonephritis. Primary C3-GP was detected in 87 % of patients, secondary - in 13 % (monoclonal gammopathies - 10 %, autoimmune diseases - 3 %).Increased level of antibodies to factor H was detected in 2 of 12 patients who underwent this study. Nucleotide variants of unknown clinical significance in complement genes were detected in 2 out of 6 patients during molecular genetic testing.CONCLUSION. C3-GP is a severe variant of glomerular damage with a heterogeneous etiological structure, which requires the use of ultrastructural and molecular diagnostics, as well as clinical analysis and identification of pathogenetic mechanisms to determine approaches to therapy.
Stubble burning: Root cause, impacts and its management in Indian scenario
Authors: Gottipati Rohith , Burra Pavan M N , Menon Sandeep 
Published: November 2021

The practice of purposefully setting fire to the residue that remained after harvest of rice and wheat crop is increasing periodically. Stubble burning has become one of the challenging issues in India in recent times. Government has been consistently instructing farmers not to burn the crop residues, instead asking them for in-situ management. Farmers are citing various complications in stubble management which pulling them to setting up fire to the stubble. Rice straw burning generates life threatening greenhouse gases which causes air pollution injury. Particulate matter (PM2.5) levels in the capital state of India (New Delhi) have been exceeded by 14 times than threshold level because of episodic agricultural fires in the neighbouring states namely Punjab, Haryana. A very limited study has been done so far on this complete issue despite of its importance. The present review tried to expose root cause, impacts on ecosystem and management strategies of stubble burning especially in India. There are plethora of possibilities in managing residue in sustainable ways including in-situ residue management, mushroom production, livestock feed, composting, biochar preparation, bio-thermal power plants and paper industries. Mechanical and effective method of in-situ management has been come into existence in the form of happy seeder. Depending on the land holding farmers can follow any of the said methods and manage their residue in sustainable way by overcoming the constraints thereby reducing the impacts on ecosystem.
Rapid in-vitro micropropagation of Bamboo (Dendrocalamus strictus) and its genetic fidelity testing using ISSR markers
Authors: Khare Shambhu Ram , Kharate Pawankumar S. , Sahu Ritesh kumar , Jha Zenu 
Published: November 2021

Bamboo is a versatile, arborescent, perennial and non-wood forest tree with tremendous commercial importance. For mass scale propagation of bamboo, the micropropagation is an effective way for producing elite, infection free and true-to-type planting material. Here, the nodal explants of Dendrocalamus strictus used to develop an effective protocol for micropropagation based on tissue culture technique. In this study, the sterilization treatment of 70% ethanol + Tween 20 + Bavistin + Hgcl2 + PPM was successfully controlled the contamination up to 90 % as compared to other treatments. The shoots were initiated from nodal segments in MS medium supplemented with BAP (4 mg/l) and PPM (500µl/l). Shoot multiplication was found best with BAP (4 mg/l) and kinetin (2 mg/l) by using liquid MS medium. Whereas, rooting in solid MS medium has shown good results when supplemented with NAA (4mg/l). Healthy and disease-free plants were obtained after hardening under greenhouse conditions. Genetic fidelity testing by using ISSR markers reported that there was no variation in plantlets developed through micropropagation.
ANALYSIS OF THE POSSIBILITY OF FORMING A STRUCTURAL SYSTEM FOR DEVELOPING ALTERNATIVE OPTIONS OF THE TECHNOLOGICAL PROCESS OF HOT VOLUME FORMING AT THE STAGE OF TECHNOLOGICAL PREPARATION OF PRODUCTION
Authors: Шибаков Владимир Георгиевич , Панкратов Дмитрий Леонидович , Низамова Лилия Миннуровна , Низамов Равиль Салимович 
Published: November 2021

Рассмотрена возможность оценки альтернативной технологии на этапе технологической подготовки производства.
The possibility of evaluating an alternative technology at the stage of technological preparation of production is considered.
Urgensi Beracara di Pengadilan Perdata Terhadap Hukum Acara perdata
Authors: Puhi Oyaldi , Akili Rustam Hs , Ahmad Ibrahim , Moonti Roy Marthen , Nuna Muten 
Published: November 2021

Hukum acara perdata merupakan hukum perdata formil, yang pada dasarnya berfungsi mempertahankan atau menegakkan hukum perdata materiil melalui pengadilan apabila terjadi pelanggaran terhadap hukum perdata materiil atau terjadi sengketa. Bahkan hukum acara perdata juga mengatur bagaimana tata cara memperoleh hak dan kepastian hukum manakala tidak terjadi sengketa melalui pengajuan “permohonan” ke pengadilan. Artikel ini ingin menjelaskan bagaimana mekanisme beracara di pengadilan perdata terhadap hukum acara perdata, dengan menggunakan metode penulisan secara normatif. Sebagai kesimpulan, artikel ini menjelaskan bahwa didalam beracara hukum acara perdata dapat ditinjau dalam dua aspek yakni dalam arti luas dan dalam arti sempit, dalam arti luas beracara meliputi segala tindakan hukum yang dilakukan, baik di luar maupun di dalam persidangan di pengadilan guna menyelesaikan suatu perkara menurut ketentuan hukum acara perdata. Sedangkan dalam arti sempit, beracara meliputi tindakan beracara di dalam persidang di pengadilan dari sidang pertama sampai dengan hakim menjatuhkan putusannya. Sedangkan untuk prosedur dalam pengajuan Gugatan di Pengadilan merujuk pada Pasal 118 ayat (1) Herizen Indlandsch Reglement (“HIR”)/Pasal 142 RBg.
Abstract. Civil procedural law is formal civil law which basically is to defend or enforce material civil law through the court if there is a violation of the law toward material civil law or a dispute. Even the civil procedural law also regulates how to obtain legal rights and certainty, if there is no dispute through filing an "application" to the court. This article aims to explain how the procedure of mechanisms in civil courts toward civil procedural law by using the normative writing method. In conclusion, this article explains that civil procedural law proceedings can be viewed in two aspects, which are broad sense and narrow sense. In the broad sense, it includes all legal actions that are taken both outside and inside the court to resolve the case according to the provisions of civil procedural law. Whereas in a narrow sense, it includes proceeding at trial in court from the first trial until the judge makes his decision. whereas, the procedure for filing a lawsuit in court is referring to Article 118 paragraph (1) Herizen Indlandsch Reglement (“HIR”) / Article 142 RBg.