bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selection of the Optimal L-asparaginase II Against Acute Lymphoblastic Leukemia: An In Silico Approach
Authors: Baral Adesh , Gorkhali Ritesh , Basnet Amit , Koirala Shubham , Bhattarai Hitesh Kumar 
Published: September 2021

Background
L-asparaginase II (asnB), a periplasmic protein commercially extracted from E coli and Erwinia, is often used to treat acute lymphoblastic leukemia. L-asparaginase is an enzyme that converts L-asparagine to aspartic acid and ammonia. Cancer cells are dependent on asparagine from other sources for growth, and when these cells are deprived of asparagine by the action of the enzyme, the cancer cells selectively die.

Objective
Questions remain as to whether asnB from E coli and Erwinia is the best asparaginase as they have many side effects. asnBs with the lowest Michaelis constant (Km; most potent) and lowest immunogenicity are considered the most optimal enzymes. In this paper, we have attempted the development of a method to screen for optimal enzymes that are better than commercially available enzymes.

Methods
In this paper, the asnB sequence of E coli was used to search for homologous proteins in different bacterial and archaeal phyla, and a maximum likelihood phylogenetic tree was constructed. The sequences that are most distant from E coli and Erwinia were considered the best candidates in terms of immunogenicity and were chosen for further processing. The structures of these proteins were built by homology modeling, and asparagine was docked with these proteins to calculate the binding energy.

Results
asnBs from Streptomyces griseus, Streptomyces venezuelae, and Streptomyces collinus were found to have the highest binding energy (–5.3 kcal/mol, –5.2 kcal/mol, and –5.3 kcal/mol, respectively; higher than the E coli and Erwinia asnBs) and were predicted to have the lowest Kms, as we found that there is an inverse relationship between binding energy and Km. Besides predicting the most optimal asparaginase, this technique can also be used to predict the most optimal enzymes where the substrate is known and the structure of one of the homologs is solved.

Conclusions
We have devised an in silico method to predict the enzyme kinetics from a sequence of an enzyme along with being able to screen for optimal alternative asnBs against acute lymphoblastic leukemia.
REFLEKSI AYAT-AYAT TOLERANSI: MEMUPUK KEBERAGAMAN DALAM MENJALANKAN SYARIAT ISLAM DI ACEH
Authors: Muthalib Salman Abdul , Umam Mushlihul 
Published: September 2021

The application of Islamic Sharia in Aceh should give birth to a tolerant diversity of life, because the qanun covers these procedures, but Aceh is considered to be intolerant of a number of groups, especially institutions that carry out research in the field of diversity, in this article the author wants to examine further the matter of stipulation. Aceh Province seems intolerant, the author examines this case through a document review then the author observes based on the reality that occurs. The result is that the authors assess that there are Non-Muslim people who igNore qanun regulations in the element of building houses of worship that are carried out without obtaining permission and have Not met the terms and conditions stipulated in the Islamic Sharia qanun, apart from these problems, the Acehnese people in general can accept the differences well. social. Therefore, the attitude of caring for unity in carrying out each other's beliefs and obeying and obeying the law of the qanun must be a shared commitment. Reflecting on and practicing the verses of tolerance will foster mutual respect and tolerance among human beings. Abstrak: Penerapan Syariat Islam di Aceh seharusnya melahirkan kehidupan keberagaman yang toleran, karena qanun telah mengcover tata cara tersebut. Tetapi, Aceh dinilai intoleran oleh sejumlah kalangan, terutama lembaga-lembaga yang melakukan riset di bidang keberagaman. Dalam artikel ini, penulis ingin mengkaji lebih lanjut perihal penetapan Provinsi Aceh sebagai daerah yang terkesan intoleran. Penulis mengkaji kasus ini melalui review dokumen dan mengamati realita yang terjadi. Hasilnya, penulis menilai adanya oknum Non-muslim yang mengabaikan peraturan qanun pada pembangunan rumah ibadah yang dilakukan tanpa izin dan belum memenuhi syarat serta ketentuan yang telah diatur dalam qanun Syariat Islam. Terlepas dari permasalahan tersebut, masyarakat Aceh pada umumnya dapat menerima dengan baik perbedaan-perbedaan sosial. Oleh karenanya, sikap merawat persatuan dalam menjalankan keyakinan masing-masing serta patuh dan taat pada hukum qanun haruslah menjadi komitmen bersama. Merenungi serta mengamalkan ayat-ayat toleransi akan menumbuhkan sikap saling menghormati dan tenggang rasa antar umat manusia.
Deradikalisasi Pemahaman Al-Qur’an (Ayat-ayat Jihad dan Qital)
Authors: Amin Husna , Akmal Saiful 
Published: September 2021

This study tries to explain the verses of the Qur'an which are often used as triggers for the emergence of radical actions. Most of the verses are verses of jihad and qital. The verses in text meaning symbolize something hard, because the meaning of jihad is serious while qital means killing. However, if a deeper study is carried out, will be found that the meaning of the verse cannot be seen only textually but also must look at environmental factors when the verse was revealed and the politics at that time. Then the Arabic word has a meaning that varies according to the context of the discussion. Then the word qital does mean to kill, but the verses that contain the word can not only be seen from the outward meaning but also reviewing the historical and sociological because al-Qur'an came down gradually according to circumstances and needs of people. Studi ini mencoba untuk menjelaskan ayat-ayat al-Qur’an yang sering digunakan sebagai pemantik terhadap munculnya tindakan radikal. Sebagian besar ayat-ayat tersebut adalah ayat yang di dalamnya terdapat kata jihad dan qital. Ayat-ayat tersebut secara zahir memang melambangkan sesuatu yang bersifat keras, karena makna jihad adalah bersungguh-sungguh sedangkan qital bermakna membunuh. Namun, jika dilakukan penelitian lebih dalam maka akan didapati bahwa makna ayat tersebut tidak bisa dilihat secara tekstual saja, tapi juga harus melihat faktor lingkungan ketika ayat tersebut diturunkan, perpolitikan pada masa itu dan kaidah-kaidah ulum al-Qur’an sebagai acuan dalam penafsiran. Dalam bahasa Arab, ada kata yang mempunyai makna yang beragam sesuai dengan konteks pembahasan. Kata qital memang berarti membunuh, namun ayat-ayat yang mengandung kata tersebut tidak bisa hanya dilihat dari makna lahiriah saja tetapi juga meninjau jejak histrori dan sosiologi waktu ketika al-Qur’an turun secara berangsur-angsur sesuai dengan keadaan dan keperluan umat.
“You Will Bring the Truth into Your Kingdom…” The Image of the “True Christian Kingdom” in Russian Spiritual and Political Writings in the Middle of the 16th Century
Authors: Perevezentsev Sergey V. 
Published: September 2021

The article examines the ideas of Russian spiritual and political thinkers of the 16th century about the “true Christian kingdom” under the conditions of expecting the imminent arrival of the Antichrist and the Second Coming of Christ. According to Russian spiritual and political figures of that time, the Russian state should fully comply with Christian notions about the ideal Christian state structure, and Russian rulers and ordinary residents should be filled with Christian piety. Only in that case, Russia could be ready to meet the “end of the world” with dignity, and its Orthodox inhabitants would be able to hope for “eternal salvation”. Therefore, throughout the 16th century in Russia, the search was constantly conducted for the most correct, from the Christian point of view, political and state structure, and domestic spiritual and political thinkers presented in their works various images of the ideal (“true”) Christian kingdom. It was important that the representatives of the interests of almost all social strata of contemporary Russian society (the peasantry, service people, boyars, the clergy) and even the tsar himself took part in those discussions.
The Metaphysical Landscape of Siberia. For the Anniversary of the Writer Anatoly Omelchuk
Authors: Rostova Natalya N. 
Published: September 2021

The article is devoted to the study of the creative work of the Russian writer Anatoly Konstantinovich Omelchuk and his place in Russian literature. Through the prism of the analysis, the author discusses such fundamental topics as: what it means to be Russian; what it means to feel at home; what art and literature are; what the meaning of modern literature crisis is; what the relation between content and form in art is. The article examines the ideas of A.K. Omelchuk regarding Siberia as metaphysical space that makes Russia Russia; about Siberia as the last territory of humanity, which today is threatened with extinction in the post-human future; about literature as kind of service to the Motherland. The author comes to the conclusion that the work of A.K. Omelchuk is located in the horizon of the tradition of Russian literature, set by F.M. Dostoevsky.
Russian Khranitel’stvo as Russian Understanding of Conservative Tradition
Authors: Aksenova Galina V. , Komarov Aleksandr A. 
Published: September 2021

“Russia, Russia! Keep yourself, keep yourself!..” – these very lines of the epigraph, taken from the poem by N.M. Rubtsov, reveal the main idea of the book by S.V. Perevezentsev and A.A. Shirinyants “Essays on the History of the Russian Khranitel’stvo”. The monograph of the two professors of Moscow University, who are well-known experts in the field of the history of Russian socio-political thought, in a sense sums up the preliminary results of their scientific research of the recent years devoted to the development and justification of the concept of “Russian Khranitel’stvo”. According to the authors “Khranitel’stvo” played an important role in the formation of the “national ideological and political tradition”, which was reflected in the works of Russian thinkers and political figures of the 11th–19th centuries. Therefore, the ideas of the Russian Khraniteli, – supporters of the unity of the historical and spiritual-political principles of Russian society and the state, run through the entire book, as well as through the entire history of Russia.
Penerapan Bahasa Jurnalistik pada Kategori Berita Hukum Kriminal Datariau.com
Authors: Listari Ayu , Ismandianto Ismandianto 
Published: September 2021

Datariau.com merupakan salah satu media online erada di Pekanbaru yang berdiri sejak 20 Agustus 2012. Meskipun telah terverifikasi oleh Dewan Pers, masih terdapat ketidaksesuaian penulisan bahasa jurnalistik yang ditemukan di situs Datariau.com. Tujuan penelitian ini untuk mengetahui bagaimana penerapan bahasa jurnalistik di portal berita kategori Hukum Kriminal Datariau.com. Penelitian ini menggunakan teori pers tanggung jawab sosial. Pendekatan yang digunakan adalah kualitatif dengan metode deskriptif analisis. Informan dalam penelitian ini redaktur pelaksana, pimpinan redaksi dan wartawan Datariau.com. Sedangkan objek penelitiannya adalah berita kategori hukum kriminal dalam portal berita Datariau.com. Teknik pengumpulan data yang digunakan yakni observasi, wawancara, dan dokumentasi. Lokasi penelitian berada di kantor redaksi Datariau.com. Hasil penelitian menunjukkan bahwa penerapan bahasa jurnalistik di portal berita kategori hukum kriminal Datariau.com masih terdapat 65 ketidaksesuaian penulisan bahasa jurnalistik dan terdapat ketidaksesuaian 4 dari 5 ciri bahasa jurnalistik yaitu kata mubazir.
Kata-kata Kunci: Bahasa Jurnalistik, Jurnalistik, Datariau.com, Berita, Hukum Kriminal
Hotel Branding Exposed: a Content Analysis of Related Organisational Values
Authors: Breznik Kristijan , Law Kris , Gorenak Mitja 
Published: September 2021

Abstract

Background/Purpose: This paper explores how organisational values can help to understand the interlinks of hotel brands and their hotel rating. The study assumes that the importance of organisational values in the service sector represents one of the key components of both growth and development of an organisation.

Methods: Conceptual content analysis was used on the dataset of organisational values found on websites of the top 100 European hotel brands. Advanced network analytic procedures were applied to identify clustered dimensions of organisational values among various hotel brands.

Results: Results identified shared organisational values among hotel brands clustered into four predominant dimensions: entrepreneurial, stakeholders, moral, and tradition. The study confirmed wide content variability of organisational values within the hotel brand industry.

Conclusion: The cluster analysis identified clusters of the most important words from values statements, concluding that hotel brands highly value “entrepreneurial” and “ethical” clusters. The island analysis approach on hotel brands’ level also reveals that organisational values in this sector are determined by many factors, including the scale and market positioning. Our study provides theoretical and practical implications to hotel brand strategists in order to better understand their current and desired sector position.
Procedural Justice, Perceived Organisational Support, and Organisational Citizenship Behaviour in Business School
Authors: Dominic Elizabeth , Victor Vijay , Nathan Robert Jeyakumar , Loganathan Swetha 
Published: September 2021

Abstract

Background/Purpose: The effectiveness of a Business School depends on the extra role behaviours or Organ-isational Citizenship Behaviour (OCB) of its committed academics. The social exchange theory postulates that employees tend to display OCB when they know how their organisation would treat them. As B-School academics’ inclination towards OCB is less understood, this study examines the interaction between Procedural Justice (PJ), Perceived Organisational Support (POS) and Organisational Citizenship Behaviour (OCB) among B-School academics.

Methods: A survey was carried out to collect data from B-School academics, 378 responses were collected from B-Schools from the state of Kerala, India. Data validity and reliability analyses, and direct and indirect effects of research variables were tested using Partial Least Square (PLS) path modelling.

Results: The results indicate PJ positively influences POS as well as dimensions of the OCB for B-School academics. Contrary to previous OCB studies, this study finds that POS do not significantly relate to Courtesy. The findings also show that POS fully mediates PJ’s relationship with Altruism, Conscientiousness and Civic Virtues of B-School academics.

Conclusion: This research explains the dynamics of PJ and POS towards OCB in a B-School setting. The academic setting of this study provides more insight into the relationships and provides insights into enhancing the organisational citizenship behaviour of academics in enhancing educational outcomes. Further, it also adds to existing understanding of organisational behaviour theory.
Relationships between Work-Family Balance, Job Satisfaction, Life Satisfaction and Work Engagement among Higher Education Lecturers
Authors: Žnidaršič Jasmina , Marič Miha 
Published: September 2021

Abstract

Background and Purpose: Our research examines the impact of work-life balance on work engagement, both direct impact as well as through job and life satisfaction. The main aim of our research is to empirically test relations between work-life balance, job satisfaction, life satisfaction, and work engagement among higher education lecturers from Austria, Croatia, Czech Republic, Germany, Serbia, and Slovenia.

Methods: Using validated questionnaires, we collected data on work-life balance, job satisfaction, life satisfaction and their work engagement. The quantitative data for our analysis were collected through a survey of 164 online participants. Based on an extensive literature review, we have formulated five hypotheses, which we tested in one structural model by using structural equation modelling (SEM).

Results: Our findings show that an increase in work-life balance positively relates to life and work satisfaction and that life satisfaction leads to an increase in work engagement.

Conclusion: The knowledge of important impact of work-life balance, together with the understanding of the relations between the researched constructs of work-life balance, life satisfaction, job satisfaction and work engagement, can strengthen teachers’ work engagement by respecting employees as actors in other roles and supporting work-family balance in the form of family-friendly policies and practices, and thereby contributes to the area of employee’s behaviour and improves the teacher’s productivity.
Ameliorasi Rizosfer Kedelai Menggunakan Jerami, Abu Sekam, dan Dolomit
Authors: Siti Ria Chaerunisa  , Munif Ghulamahdi  , Lubis Iskandar 
Published: September 2021

Successful saturated soil culture practices in tidal land to increase soybean production needs to be supported by amelioration. The rhizosphere is an area where the intensive reciprocal relationship between plants, soil, and soil microorganisms occured. However, the effect of amelioration through the rhizosphere is still unclear. This research aimed to study the effect of amelioration using rice straw, rice husk ash, and dolomite on the rhizosphere on the growth and production of soybean. The research was conducted in tidal swamp land type B overflow from May to August 2019. The experimental design used was a split-split plot design with rice straw, rice husk ash, and dolomite as the main plot, subplots, and sub subplots, respectively. Rice straw was applied by embedding in the soil, while rice husk ash and dolomite were applied to the rhizosphere during planting. The observations included plant biomass dry weight, leaf nutrient concentration of P, Fe, and Al, number of filled pods, and soybean productivity. The application of rice husk ash with rice straw or with dolomite increased soybean growth and production. The combination of 400 kg ha-1 of rice husk ash and 4 ton ha-1 of rice straw yielded the highest productivity with the value of 2.94 ton ha-1.
Keywords: abiotic stresses, rhizosphere, saturated soil culture, tidal land
Penerapan MRP Pada Persediaan Material Dan Pengaruhnya Terhadap Ketepatan Waktu
Authors: Laksana Gede Widya Jaya , Suriadi I Gusti Agung Kade , Lokantara I Putu 
Published: September 2021

PT. X sudah dapat memproduksi kendaraan roda empat berkisar 300 buah/hari, pada saat penulis melaksanakan penelitian beberapa kali sempat terjadi bottle neck pada pos kerja perakitan engine sehingga hal tersebut menjadi dorongan bagi penulis untuk mencari tahu permasalahan yang sebenarnya sedang terjadi. Setelah melakukan observasi dan mewawancarai operator serta kepala staff yang bertugas pada assy-line mendapatkan hasil bahwa terhambatnya proses produksi tersebut dikarenakan terjadinya keterlambatan pada part yang dibutuhkan pada pos tersebut, maka dari itu dilaksanakan penelitian mengenai penerapan metode (MRP) material requirements planning, penelitian ini bertujuan untuk mengoptimalkan kinerja daripada suatu proses produksi material mentah menjadi bahan jadi yang bernilai jual tinggi, agar dapat terlaksana dengan tepat waktu dan dengan jumlah material yang tepat. Penelitian ini dilaksanakan dengan membuat master production schedule (MPS) atau jadwal induk produksi kemudian membuat catatan ketersediaan material dilanjutkan dengan membuat bill of material (BOM) atau struktur produk dari engine dan melakukan perhitungan peramalan permintaan menggunakan metode time series. Seluruh data yang telah diolah akan menjadi dasar dari pembuatan MRP, dengan jumlah produksi sebanyak 877 buah pada minggu ke-V Bulan April dan 864 buah pada minggu ke-I Bulan Mei menerapkan MRP pada suatu proses produksi dapat meningkatkan produktivitas kerja. Hasil perhitungan waktu yang didapat menunjukkan bahwa tidak terjadi bottle neck pada perhitungan MRP minggu ke-III, ke-IV dan ke-V
X Inc. has been able to produce approximately 300 pieces of four-wheel vehicles per day, when the author carried out this research, there were some bottle necks happened several times on the work post of the engine assembly where it became a motivation for the author to find out what problems are going on. After observing and interviewing operator and chief of staff on the assy-line, it was concluded that the obstructed production process was caused by a delay in the needed parts on the said post, therefore a research about the application method of Material Requirement Planning (MRP) is carried out, where this research is aimed to optimize the production process of raw into finished, high valued materials, and can be done in a timely manner with exact amount of materials. This study was done by making a Master Production Schedule (MPS), then, making a material availability notation, continued by making a Bill of Material (BOM) and calculating the demand forecasting using the time series method. The entire data that had been processed became the base of the MRP-making, with the total production as many as 877 on the 5th week of April and 864 on the 1st week of May. Applying MRP on the production process can increase work productivity. The result of the time calculation obtained indicates that there was no bottle neck in the 3rd, 4th, and 5th week MRP calculation.
Pengaruh Lamanya Waktu Penyimpanan Biogas Terhadap Komposisi Biogas
Authors: Adanyana I Wayan Putra , Nindha Tjok Gde Tirta , Surata I Wayan 
Published: September 2021

Biogas merupakan gas yang di hasilkan dari limbah organik yang dapat di perbaharui dan dapat di jadikan bioergi, komposisi yang terkandung dalam biogas yaitu gas hydrogen sulfida (H2S), gas karbon dioksida (CO2), oksigen (O2), H2O dan gas metana (CH4). Lamanya waktu penyimpanan biogas yaitu untuk mengetahui pengaruh komposisi biogas selama penyimpanan. Kapasitas bag yang di gunakan dalam penelitian ini berkapasitas 100 lt biogas disimpan selama 21 hari , komposisinya di uji setiap hari sampai hari ke 7 dan kembali di uji komposisinya di hari ke 21 dengan aliran biogas 3 liter per menit. Perbandingan data dalam penelitian ini biogas di simpan dalam 2 bag, bag 1 tersimpan biogas belum di murnikan , bag ke 2 tersimpan biogas yang belum di murnikan dan di tambahkan kalsium klorida (CaCl2) di dalam bag. Hasil dari penelitian ini menunjukkan peningkatan komposisi CH4 sebesar 62 % dengan penambahan CaCl2 dalam bag ke 2 dan menurunnya komposisi H2S dsan CO2 dibandingkan biogas yang tersimpan di bag 1 komposisi CH4 hanya 47 %.
Biogas is a gas produced from organic waste that can be renewed and can be made into bioergy, the composition contained in biogas is hydrogen sulfide gas (H2S), carbon dioxide gas (CO2), oxygen gas (O2), H2O and methane gas (CH4). The length of time for biogas storage is to determine the effect of biogas composition during storage. The capacity of the bag used in this study with a capacity of 100 liters of biogas is stored for 21 days, the composition is tested every day until the 7th day and the composition is tested again on the 21st day with a biogas flow of 3 liters per minute. Comparison of data in this study biogas stored in 2 bags, bag 1 stored biogas not purified, bag 2 stored biogas that has not been purified and added calcium chloride (CaCl2) in the bag. The results of this study showed an increase in the composition of CH4 by 62% with the addition of CaCl2 in bag 2 and a decrease in the composition of H2S and CO2 compared to biogas stored in bag 1 in the composition of CH4 was only 47%.