bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Because it's easier to kill that way’: Dehumanizing epithets, militarized subjectivity, and American necropolitics
Authors: McIntosh Janet 
Published: August 2021

AbstractThis article examines the blunt conceptual instrument of dehumanizing American military terms for the enemy in the context of the Vietnam War and the Global War on Terror. I examine language that dehumanizes American service members themselves, who are semiotically framed as expendable. Next, I explore the essentialist, semi-propositional qualities of derogatory epithets for the enemy and the affectively charged, deadly stances they encourage. I examine how generic references to the enemy during training make totalizing claims that risk encompassing civilians in their typifications. And I show that, in the context of war, the instability of derogatory epithets can manifest itself when the servicemember is confronted with the behavioral idiosyncrasies and personal vulnerabilities of actual ‘enemies’ on the ground. The putative folk wisdom found in generic references to the enemy can thus fall apart when confronted with countervailing experience; in such cases, service members may shift stance by renouncing military epithets. (Military language, epithets, slurs, generics, othering, dehumanization, necropolitics)*
The social (and cultural, and syntactic, and semantic) life of generics
Authors: Mannheim Bruce 
Published: August 2021

ABSTRACTRecent work in linguistics, philosophy, and psychology suggests that the distinction between generic and specific (singular) reference is foundational to concept formation, and hence of special interest to social scientists. Generics provide the first-language learner with external evidence of the integrity of a word/concept cluster, partially filling in the scaffolding of concepts. As such, they arereplicators,critical to the transmission of concepts across populations and across time. Generics are tacitly normative. As they refer to the constitutive properties of a concept rather than to its object, they tell us what—in a given social setting—a proper instance of the concept should look like. Generics sustain and reproduce social stereotypes, including—and perhaps especially—ethnoracial, class, and gender stereotypes. (Generics, conceptual formation, ethnography, tokenization, materiality)*
INDIVIDUAL DIFFERENCES IN HOW LANGUAGE LEARNERS PURSUE GOALS
Authors: Teimouri Yasser , Papi Mostafa , Tahmouresi Somayeh 
Published: August 2021

AbstractIn two studies, we examined two functional dimensions of L2 learners’ self-regulation toward their motivational goals: assessment and locomotion. The assessment constitutes the aspect of self-regulation concerned with critically evaluating the relative quality of L2 states and goals and the means to achieve them. The locomotion mode constitutes the aspect of self-regulation concerned with uninterrupted movement from state to state toward L2 goals. We developed two scales to measure L2 self-regulatory modes. We also examined how L2 learners’ regulatory modes were associated with their emotional experiences, motivation, and language proficiency. Psychometric work attested to the reliability and validity of the two scales. Moreover, regression analyses revealed that each L2 self-regulatory mode has distinct emotional, motivational, and linguistic emphases. Finally, cluster analyses suggested that both L2 self-regulatory modes should work together for optimal L2 learning outcomes.
Four-site skinfolds thickness percentiles of schoolchildren and adolescents in Turkey
Authors: Soylu Meltem , Şensoy Nazlı , Doğan İsmet , Doğan Nurhan , Mazıcıoğlu M Mümtaz , Öztürk Ahmet 
Published: August 2021

AbstractObjective:The primary purpose of the current study was to establish Turkish smoothed centile charts and Lambda, Mu, Sigma (LMS) tables for four-site skinfold thickness based on a population-based sample, and secondary purpose was to elaborate a reference for the percentage of body fat.Design:A cross-sectional and descriptive study was conducted between January and May 2017. Triceps, biceps and subscapular, suprailiac skinfold thicknesses were measured using Holtain skinfold caliper. Age- and gender-specific percentile values were determined with the LMS method, and body fat percentage was calculated using the Westrate and Deurenberg equation.Setting:Afyonkarahisar province in Turkey.Participants:The current study was conducted on 4565, 6–18-year-old students.Results:The triceps, biceps and subscapular skinfolds of the girls were higher than the boys. From the age of seven, the sum of four skinfold thicknesses of the girls was more than those of the boys. This difference became more evident after the age of 12. Although fat percentages of girls showed a fluctuating change, it decreased with the age in boys. Westrate and Deurenberg equation fat percentages of girls until adolescence were lower than boys, but increased after 12 years of age and exceeded that of boys.Conclusions:The current study has provided sex- and age-specific reference values for skinfold thickness and has shown that obesity in girls is higher than in boys in schoolchildren in Afyonkarahisar. The current study has also shown that skinfold thickness measurements are a valuable tool for screening obesity in children.
Prevalence and correlates of US adult public opinion on restricting junk food advertising to children on social media: 2020 Health Information National Trends Survey
Authors: Korn Ariella R , Blake Kelly D , D’Angelo Heather , Reedy Jill , Oh April 
Published: August 2021

AbstractObjective:To describe US adults’ levels of support, neutrality and opposition to restricting junk food advertising to children on social media and explore associations with socio-demographic and health-related characteristics.Design:In 2020–2021, we used cross-sectional data from the National Cancer Institute’s 2020 Health Information National Trends Survey to estimate the prevalence of opinions towards advertising restrictions and correlates of neutrality and opposition using weighted multivariable logistic regression.Setting:United States.Participants:Adults aged 18+ years.Results:Among the analytic sample (n 2852), 54 % of adults were neutral or opposed to junk food advertising restrictions on social media. The odds of being neutral or opposed were higher among Non-Hispanic Black adults (v. non-Hispanic White; OR: 2·03 (95 % CI 1·26, 3·26)); those completing some college (OR: 1·68 (95 % CI 1·20, 2·34)) or high school or less (OR: 2·62 (95 % CI 1·74, 3·96)) (v. those with a college degree); those who were overweight (v. normal weight; OR: 1·42 (95 % CI: 1·05, 1·93)) and those reporting a moderate (OR: 1·45 (95 % CI 1·13, 1·88)) or conservative (OR: 1·71 (95 % CI 1·24, 2·35)) political viewpoint (v. liberal). Having strong (v. weaker) weight and diet-related cancer beliefs was associated with 53 % lower odds of being neutral or opposed to advertising restrictions (OR: 0·47 (95 % CI 0·36, 0·61)).Conclusions:The current study identified subgroups of US adults for whom targeted communication strategies may increase support for policies to improve children’s food environment.
Geological Records of Coseismic Shear Localization Along the Yangsan Fault, Korea
Authors: Gu Dohee , Han Raehee , Woo Sangwoo 
Published: August 2021

AbstractWe conducted outcrop‐to‐nanoscale structural observations on a principal slip zone (PSZ) of the Yangsan fault, a major strike‐slip fault in southeast Korea, and some high‐velocity rotary shear tests on the PSZ gouges to understand shear localization and physico‐chemical processes in the PSZ during earthquakes. At the fault outcrop, the PSZ appears 1–2 cm thick. At smaller scales, the PSZ is subdivided into Units 1 to 4 based on their microstructures. Microscopic observations confirmed the shear localization in Units 1 (20–500 μm in thickness) and 3 (0.8–3 mm in thickness). Further localization was observed in several μm‐thick shear bands. Various structural and mineralogical features that recorded physico‐chemical processes in slip zones were found in the PSZ, including gouge fluidization structures relevant to thermal pressurization, solidified frictional melt of clay‐rich gouge, and mineralogical changes by frictional heating‐induced illitization. The gouge melting and mineralogical changes were reproduced in our experiments at 1.3 m s−1. The gouge fluidization has been observed in previous tests at seismic slip rates. Thus, the observations from the natural and experimental faults indicate that the shear localization in the PSZ was coseismic. In a cataclasite zone next to the PSZ, altered veins of pseudotachylyte were found. All these observations indicate temporal changes of the PSZ materials (e.g., formation of solidified melt, alteration of the melt into clay minerals, friction‐induced mineralogical changes). Associated with such changes, coseismic slip zone processes and dominant weakening mechanisms may also vary, even at the same location on a fault.
Cluster Observations of Energetic Electron Acceleration Within Earthward Reconnection Jet and Associated Magnetic Flux Rope
Authors: Vaivads A. , Khotyaintsev Yu. V. , Retinò A. , Fu H. S. , Kronberg E. A. , Daly P. W. 
Published: August 2021

AbstractWe study acceleration of energetic electrons in an earthward plasma jet due to magnetic reconnection in the Earth magnetotail for one case observed by Cluster. The case has been selected based on the presence of high fluxes of energetic electrons, Cluster being in the burst mode and Cluster separation being around 1,000 km that is optimal for studies of ion scale physics. We show that two characteristic acceleration mechanisms are operating during this event. First, significant acceleration is achieved inside the magnetic flux pile‐up of the jet, the acceleration mechanism being consistent with betatron acceleration. Second, strong energetic electron acceleration occurs in magnetic flux rope like structure forming in front of the magnetic flux pile‐up region. Energetic electrons inside the magnetic flux rope are accelerated predominantly in the field‐aligned direction and the acceleration can be due to Fermi acceleration in a contracting flux rope.
A Statistical Study of Low‐Energy Ion Flux Enhancements by EMIC Waves in the Inner Magnetosphere
Authors: Lee Junhyun , Kim Khan‐Hyuk , Lee Ensang 
Published: August 2021

AbstractWe have studied the statistical properties of low‐energy proton (H+) and helium (He+) ion flux enhancements associated with electromagnetic ion cyclotron (EMIC) waves in the inner magnetosphere using Van Allen Probes data for 2013–2017. We identified 167 low‐energy ion flux enhancements when the EMIC waves occurred in a He‐band or in a multiple band (H‐band and He‐band) with strong He‐band and weak H‐band wave activity and found that most of them occurred from the noon to the premidnight sector near the magnetic equator just inside the plasmapause. Of 167 flux enhancement events, 68 exhibited only He+ flux enhancements, and 99 exhibited both H+ and He+ flux enhancements. The EMIC wave‐associated flux enhancement events are mostly energized in the direction perpendicular to the background magnetic field. When both H+ and He+ fluxes are simultaneously enhanced, the H+ flux events have a peak energy distributed in the range of 2–100 eV, and the peak energies of the He+ flux events are distributed in the 2–600 eV range, implying that the helium ions are more energized than the protons. The peak energies of only He+ flux enhancement without H+ flux enhancement are mostly distributed in a lower energy range, 2–10 eV. The energization of H+ and He+ ions can be explained by a linear plasma flow associated with EMIC waves. We suggest that the wave‐associated linear plasma motion is a likely mechanism to explain the observations.
Histone demethylase KDM4A plays an oncogenic role in nasopharyngeal carcinoma by promoting cell migration and invasion
Authors: Zhao Jingyi , Li Bingyan , Ren Yongxia , Liang Tiansong , Wang Juan , Zhai Suna , Zhang Xiqian , Zhou Pengcheng , Zhang Xiangxian , Pan Yuanyuan , Gao Fangfang , Zhang Sulan , Li Liming , Yang Yongqiang , Deng Xiaoyu , Li Xiaole , Chen Linhui , Yang Daoke , Zheng Yingjuan 
Published: August 2021

AbstractCompelling evidence has indicated the vital role of lysine-specific demethylase 4 A (KDM4A), hypoxia-inducible factor-1α (HIF1α) and the mechanistic target of rapamycin (mTOR) signaling pathway in nasopharyngeal carcinoma (NPC). Therefore, we aimed to investigate whether KDM4A affects NPC progression by regulating the HIF1α/DDIT4/mTOR signaling pathway. First, NPC and adjacent tissue samples were collected, and KDM4A protein expression was examined by immunohistochemistry. Then, the interactions among KDM4A, HIF1α and DDIT4 were assessed. Gain- and loss-of-function approaches were used to alter KDM4A, HIF1α and DDIT4 expression in NPC cells. The mechanism of KDM4A in NPC was evaluated both in vivo and in vitro via RT-qPCR, Western blot analysis, MTT assay, Transwell assay, flow cytometry and tumor formation experiments. KDM4A, HIF1α, and DDIT4 were highly expressed in NPC tissues and cells. Mechanistically, KDM4A inhibited the enrichment of histone H3 lysine 9 trimethylation (H3K9me3) in the HIF1α promoter region and thus inhibited the methylation of HIF1α to promote HIF1α expression, thus upregulating DDIT4 and activating the mTOR signaling pathway. Overexpression of KDM4A, HIF1α, or DDIT4 or activation of the mTOR signaling pathway promoted SUNE1 cell proliferation, migration, and invasion but inhibited apoptosis. KDM4A silencing blocked the mTOR signaling pathway by inhibiting the HIF1α/DDIT4 axis to inhibit the growth of SUNE1 cells in vivo. Collectively, KDM4A silencing could inhibit NPC progression by blocking the activation of the HIF1α/DDIT4/mTOR signaling pathway by increasing H3K9me3, highlighting a promising therapeutic target for NPC.
N-methyl-D-aspartate receptor availability in first-episode psychosis: a PET-MR brain imaging study
Authors: Beck Katherine , Arumuham Atheeshaan , Veronese Mattia , Santangelo Barbara , McGinnity Colm J. , Dunn Joel , McCutcheon Robert A. , Kaar Stephen J. , Singh Nisha , Pillinger Toby , Borgan Faith , Stone James , Jauhar Sameer , Sementa Teresa , Turkheimer Federico , Hammers Alexander , Howes Oliver D. 
Published: August 2021

AbstractN-methyl-D-aspartate receptor (NMDAR) hypofunction is hypothesised to underlie psychosis but this has not been tested early in illness. To address this, we studied 40 volunteers (21 patients with first-episode psychosis and 19 matched healthy controls) using PET imaging with an NMDAR selective ligand, [18F]GE-179, that binds to the ketamine binding site to index its distribution volume ratio (DVR) and volume of distribution (VT). Hippocampal DVR, but not VT, was significantly lower in patients relative to controls (p = 0.02, Cohen’s d = 0.81; p = 0.15, Cohen’s d = 0.49), and negatively associated with total (rho = −0.47, p = 0.04), depressive (rho = −0.67, p = 0.002), and general symptom severity (rho = −0.74, p < 0.001). Exploratory analyses found no significant differences in other brain regions (anterior cingulate cortex, thalamus, striatum and temporal cortex). These findings are consistent with the NMDAR hypofunction hypothesis and identify the hippocampus as a key locus for relative NMDAR hypofunction, although further studies should test specificity and causality.
Drug addiction: from bench to bedside
Authors: Cheron Julian , Kerchove d’Exaerde Alban de 
Published: August 2021

AbstractDrug addiction is responsible for millions of deaths per year around the world. Still, its management as a chronic disease is shadowed by misconceptions from the general public. Indeed, drug consumers are often labelled as “weak”, “immoral” or “depraved”. Consequently, drug addiction is often perceived as an individual problem and not societal. In technical terms, drug addiction is defined as a chronic, relapsing disease resulting from sustained effects of drugs on the brain. Through a better characterisation of the cerebral circuits involved, and the long-term modifications of the brain induced by addictive drugs administrations, first, we might be able to change the way the general public see the patient who is suffering from drug addiction, and second, we might be able to find new treatments to normalise the altered brain homeostasis. In this review, we synthetise the contribution of fundamental research to the understanding drug addiction and its contribution to potential novel therapeutics. Mostly based on drug-induced modifications of synaptic plasticity and epigenetic mechanisms (and their behavioural correlates) and after demonstration of their reversibility, we tried to highlight promising therapeutics. We also underline the specific temporal dynamics and psychosocial aspects of this complex psychiatric disease adding parameters to be considered in clinical trials and paving the way to test new therapeutic venues.
High-dose methotrexate is effective for prevention of isolated CNS relapse in diffuse large B cell lymphoma
Authors: Ong Shin Yeu , de Mel Sanjay , Grigoropoulos Nicholas Francis , Chen Yunxin , Tan Yan Chin , Tan Melinda Si Yun , Ng Lawrence Cheng Kiat , Lee Yuh Shan , Phipps Colin , Goh Yeow Tee , Yong Kar Ying , Liu Xin , Chng Wee Joo , Lim Soon Thye , Nagarajan Chandramouli 
Published: August 2021

AbstractThe role of central nervous system (CNS) prophylaxis with high-dose methotrexate (HDMTX) in DLBCL is controversial. In this retrospective study, we evaluated the efficacy of prophylactic HDMTX on isolated CNS relapse, concomitant CNS and systemic relapse, systemic relapse, and survival outcomes in 226 patients with newly diagnosed DLBCL and high-risk CNS International Prognostic Index (CNS-IPI) score treated with RCHOP. The three-year risk of isolated CNS relapse was significantly lower in patients who received HDMTX, at 3.1% compared to 14.6% (P = 0.032) in those who did not. However, neither concomitant CNS-systemic relapse rates, systemic relapse rates, nor three-year PFS and OS were significantly different between treatment groups in multivariable analysis. Among propensity score-matched patients (N = 102), HDMTX was also associated with significantly lower isolated CNS relapse rates (HR 0.06, 95% CI 0.004–0.946, P = 0.046). HDMTX was well tolerated with manageable toxicities when given at a dose of 3 g/m2 by day 3 of RCHOP chemotherapy. Using propensity score matching and multivariable regression to yield treatment groups with well-balanced covariates, we showed that prophylactic HDMTX improved isolated CNS relapse rates but did not decrease concomitant CNS-systemic relapse rates, systemic relapse rates, or improve survival outcomes.
Looking for pathways related to COVID-19: confirmation of pathogenic mechanisms by SARS-CoV-2–host interactome
Authors: Messina Francesco , Giombini Emanuela , Montaldo Chiara , Sharma Ashish Arunkumar , Zoccoli Antonio , Sekaly Rafick-Pierre , Locatelli Franco , Zumla Alimuddin , Maeurer Markus , Capobianchi Maria R. , Lauria Francesco Nicola , Ippolito Giuseppe 
Published: August 2021

AbstractIn the last months, many studies have clearly described several mechanisms of SARS-CoV-2 infection at cell and tissue level, but the mechanisms of interaction between host and SARS-CoV-2, determining the grade of COVID-19 severity, are still unknown. We provide a network analysis on protein–protein interactions (PPI) between viral and host proteins to better identify host biological responses, induced by both whole proteome of SARS-CoV-2 and specific viral proteins. A host-virus interactome was inferred, applying an explorative algorithm (Random Walk with Restart, RWR) triggered by 28 proteins of SARS-CoV-2. The analysis of PPI allowed to estimate the distribution of SARS-CoV-2 proteins in the host cell. Interactome built around one single viral protein allowed to define a different response, underlining as ORF8 and ORF3a modulated cardiovascular diseases and pro-inflammatory pathways, respectively. Finally, the network-based approach highlighted a possible direct action of ORF3a and NS7b to enhancing Bradykinin Storm. This network-based representation of SARS-CoV-2 infection could be a framework for pathogenic evaluation of specific clinical outcomes. We identified possible host responses induced by specific proteins of SARS-CoV-2, underlining the important role of specific viral accessory proteins in pathogenic phenotypes of severe COVID-19 patients.
Constitutive BAK/MCL1 complexes predict paclitaxel and S63845 sensitivity of ovarian cancer
Authors: Liu Dongyan , Hou Xiaonan , Wu Wangyu , Zanfagnin Valentina , Li Yunjian , Correia Cristina , Zhao Zhiyang , Zhao Chenggang , Liu Zhirong , Zhang Tao , Fang Zhiyou , Wang Hongzhi , Xu Chao , Weroha Saravut J. , Kaufmann Scott H. , Dai Haiming 
Published: August 2021

AbstractWe previously found that preformed complexes of BAK with antiapoptotic BCL2 proteins predict BH3 mimetic sensitivities in lymphohematopoietic cells. These complexes have not previously been examined in solid tumors or in the context of conventional anticancer drugs. Here we show the relative amount of BAK found in preformed complexes with MCL1 or BCLXL varies across ovarian cancer cell lines and patient-derived xenografts (PDXs). Cells bearing BAK/MCL1 complexes were more sensitive to paclitaxel and the MCL1 antagonist S63845. Likewise, PDX models with BAK/MCL1 complexes were more likely to respond to paclitaxel. Mechanistically, BIM induced by low paclitaxel concentrations interacted preferentially with MCL1 and displaced MCL1-bound BAK. Further studies indicated that cells with preformed BAK/MCL1 complexes were sensitive to the paclitaxel/S63845 combination, while cells without BAK/MCL1 complexes were not. Our study suggested that the assessment of BAK/MCL1 complexes might be useful for predicting response to paclitaxel alone or in combination with BH3 mimetics.
KAT2A-mediated AR translocation into nucleus promotes abiraterone-resistance in castration-resistant prostate cancer
Authors: Lu Dingheng , Song Yarong , Yu Ying , Wang Decai , Liu Bing , Chen Liang , Li Xuexiang , Li Yunxue , Cheng Lulin , Lv Fang , Zhang Pu , Xing Yifei 
Published: August 2021

AbstractAbiraterone, a novel androgen synthesis inhibitor, has been approved for castration-resistant prostate cancer (CRPC) treatment. However, most patients eventually acquire resistance to this agent, and the underlying mechanisms related to this resistance remain largely unelucidated. Lysine acetyltransferase 2 A (KAT2A) has been reported to enhance transcriptional activity for certain histone or non-histone proteins through the acetylation and post-translational modification of the androgen receptor (AR). Therefore, we hypothesised that KAT2A might play a critical role in the resistance of prostate tumours to hormonal treatment. In this study, we found that KAT2A expression was increased in abiraterone-resistant prostate cancer C4-2 cells (C4-2-AbiR). Consistently, elevated expression of KAT2A was observed in patients with prostate cancer exhibiting high-grade disease or biochemical recurrence following radical prostatectomy, as well as in those with poor clinical survival outcomes. Moreover, KAT2A knockdown partially re-sensitised C4-2-AbiR cells to abiraterone, whereas KAT2A overexpression promoted abiraterone resistance in parental C4-2 cells. Consistent with this finding, KAT2A knockdown rescued abiraterone sensitivity and inhibited the proliferation of C4-2-AbiR cells in a mouse model. Mechanistically, KAT2A directly acetylated the hinge region of the AR, and induced AR translocation from the cytoplasm to the nucleus, resulting in increased transcriptional activity of the AR-targeted gene prostate specific antigen (PSA) leading to resistance to the inhibitory effect of abiraterone on proliferation. Taken together, our findings demonstrate a substantial role for KAT2A in the regulation of post-translational modifications in AR affecting CRPC development, suggesting that targeting KAT2A might be a potential strategy for CRPC treatment.