bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regorafenib is suitable for advanced colorectal cancer patients who have previously received trifluridine/tipiracil plus bevacizumab
Authors: Matsumoto Toshihiko , Ikoma Tatsuki , Yamamura Shogo , Miura Kou , Tsuduki Takao , Watanabe Takanori , Nagai Hiroki , Takatani Masahiro , Yasui Hisateru 
Published: April 2021

Abstract
Background: Regorafenib is a standard salvage line therapy used for advanced colorectal cancer (CRC). Recently, FTD/TPI plus bevacizumab also showed promising efficacy as a salvage line therapy for advanced CRC. However, the efficacy and safety of regorafenib for patients with advanced CRC who have previously received trifluridine/tipiracil (TFTD) plus bevacizumab is unclear.Results: We retrospectively collected clinicopathologic data from patients with advanced CRC who received regorafenib after TFTD plus bevacizumab in multiple institutions between April 2017 and June 2020.Thirty-four advanced CRC patients who received regorafenib were analyzed. The median age was 66.5 (range 43−81 years), 11 patients were male, and all had an ECOG performance status(PS) of 0 or 1. Twenty-two patients had left-sided tumors, 18 patients had RAS mutants, and 1 patient had a BRAF V600E mutation. The response rate was 0%, and the disease control rate was 31%. The median progression-free survival was 70 days (95% CI: 56−91), and the overall survival was 233 days (95% CI: 188−324). Treatment was discontinued in 32 patients, and 28 (82%) discontinued treatment due to progressive disease. The major grade 3 and4 toxicities were proteinurea (29%), hypertension (26%), hand-foot syndrome(15%), and platelet decrease (6%).Conclusion: Regorafenib after TFTD plus bevacizumab showed efficacy similar to that of the previous study, and no new adverse events were observed.
Investigation of Vitamin D Levels in Children Aged 0–4 Years in Yunnan Province
Authors: Wu Yuqin , Yang Yanfei , Xiao Xiao , Wang Lin , Yin Zheng , Li Yangfang 
Published: April 2021

Abstract
Aim: To investigate the vitamin D levels in children aged 0–4 years in Yunnan Province.Methods: This study selected children aged 0 to 4 years who underwent physical examination in the special needs clinic of the Hospital from October 2019 to December 2020 as subjects to analyze serum 25(OH)D levels.Result: Vitamin D deficiency was more common in girls than in boys. There was no significant difference in serum vitamin D levels between boys and girls at any age. However, there was a significant decrease in vitamin D levels after 2 years old in all chidren at all ages. The levels of vitamin D in children were highest in summer, which were significantly higher than other seasons, and were lowest in winter. At the same time, vitamin D levels were significantly different based on the economic level of cities. The serum vitamin D contents of infants and young children in the top five cities with the highest economic levels were significantly higher than in lower-ranked cities. There was a significant correlation between vitamin D content and serum calcium. Conclusion: This study preliminarily determined a reasonable reference range for serum 25 hydroxyvitamin D content in infants aged 0–4 years in Yunnan Province. Which will be of significance for the establishment of official guidelines on vitamin D supplementation in infants and young children in Yunnan and for policy formulation.
Cultivation of Pleurotus Ostreatus on Agricultural Waste and their Combination
Authors: Fufa Bulti Kumera , Tadesse Belsti Atnkut , Tulu Mestawot Merid 
Published: April 2021

Abstract
Background:Mushrooms are increasingly becoming an important component of diets worldwide and it is of paramount importance to choose appropriate substrates to grow them. The objective of this study was to grow Pleurotus ostreatus using different agricultural substrates.Methods:Corncobs, Finger millet straw and Bamboo waste were collected from different sites of Awi zone. The substrates were chopped in to small pieces and 500g of their dry mass alone and their combination was measured packed in polythene bag, moistened, and pasteurized. The cooled substrates inoculated with a spoon of P. ostreatus spawn brought from Debre Berhan University. The bags were placed in growing room and growth parameters were recorded continuously with monitoring of environmental variables. The experimental setup was completely randomized design, six treatments with three replicates.Results: The fastest spawn running phase of P. ostreatus was observed in 28.71±0.80 days, pinhead formation of 32.36±0.26 days and fruiting bodies formation of 5.19±0.74 days after pinhead appearance was recorded on Corncob substrate. The highest fresh weight and biological efficiency with significant statistical association was obtained from the P. ostreatus grown on Finger millet straw (253.07±1.05 and 50.20±0.47 respectively). The highest average number of pinhead and fruiting bodies (29.60 and 11.44 respectively) was recorded on Finger millet straw. The lowest biological efficiency (20.80±0.41), fresh weight (101.48±0.91), number of pinhead (14.40), number of fruiting bodies (4.25) was recorded from a mixture of Corncob and Bamboo waste (50% each) substrates.Conclusion:The use of mixed Corncob and Bamboo waste (1:1) for cultivation of P. ostreatus is not encouraged due to poor growth performance.
The Nordic Maintenance Care Program: Patient Experience of Maintenance Care - A Qualitative Study
Authors: Hjertstrand Jesper , Palmgren Per J , Axén Iben , Eklund Andreas 
Published: April 2021

Abstract
Background:Low back pain is one of the major causes of disability world-wide. Most back pain sufferers experience pain that is recurrent or persistent, making management of this condition a priority. In a series of previous studies, chiropractic maintenance care has been found to be an effective way of reducing the number of days with pain, particularly for patients with a certain psychological profile. However, little is known about patients’ experience of this kind of management plan.This study aimed to explore patient experiences and preferences by looking at barriers to and facilitators of engaging in and maintaining a care plan, and to contrast the data using psychological sub-groups.Methods:In this qualitative study we performed semi-structured interviews with 24 patients who had previously participated in a Swedish trial evaluating maintenance care. They were purposefully selected to obtain richness, variation and breadth of data. The data were analyzed using inductive qualitative manifest and latent content analysis. We used the theory of planned behavior to deepen our understanding of the constructed themes. Results:The analysis resulted in two overarching dimensions: “when maintenance care is of high value” and “when maintenance care is of low value”. Four factors were jointly identified as obstacles to maintenance care by patients in all the psychological subgroups. These factors were: Cost demanding, A sense of low value, Perceived as unavailable and Fear of treatment. The one factor seen as facilitating maintenance care by patients in all the subgroups was Care that is patient-centered.Conclusions:The findings reveal a variance of both positive and negative experiences of MC in the psychological subgroups. These findings can deepen our understanding of how patients experience MC and can help clinicians to understand when patients might regard maintenance care as being of high value.
Child Sexual Abuse in Pakistan: Evidence-informed Policy Framework
Authors: Abbas Syed Saleem 
Published: April 2021

Abstract
Current policy response towards issue of child sexual abuse in Pakistan is not strategic and evidence-informed but incidents based and populist. Moreover, socio-economic, cultural and political factors influences also influence the policy response for addressing the problem of child sexual abuse (CSA). This study is an attempt to suggest the evidence-informed best practices regarding preventive and curative aspects of child sexual abuse in a policy framework. Using ICAST-R tool, 18-24 years old 274 university students were asked about their experiences of sexual abuse during childhood. After critical analysis of policy a rational and evidence-informed policy based on child rights framework and community development approach is proposed for identification of CSA, its prevention, addressing cultural barriers, responding to reported cases and other aspects. Overall, 41.69% respondents were sexually abused with one or other form of sexual abuse. Experience of CSA was reported more frequently by boys than girls. Only 34.21% of sexually abused children disclosed to someone and 65.78% victims of sexual abuse never disclosed the experience of sexual abuse to anyone. Among the victims of abuse who disclosed the abuse to someone only 12.82% disclosed within a day. Majority of disclosures (50.98%) were made to friend/peer, followed by parents (11.76%) and siblings (7.84%). Very small percentage of victims reported the abuse to doctor (3.92%), police (1.96%) or a counselor / social worker (1.96%).
Abnormal Synergistic Gait Mitigation after Acute Stroke Using an Innovative Ankle-Knee-Hip Interlimb Humanoid Robot: A Randomized Controlled Trial
Authors: Park Chanhee , Oh-Park Mooyeon , Bialek Amy , Friel Kathleen , Edwards Dylan , You Joshua(Sung) H. 
Published: April 2021

Abstract
Abnormal spasticity and associated synergistic patterns are the most common neuromuscular impairments affecting ankle-knee-hip interlimb coordinated gait kinematics and kinetics in patients with hemiparetic stroke. Although patients with hemiparetic stroke undergo various treatments to improve gait and movement, it remains unknown how spasticity and associated synergistic patterns change after robot-assisted and conventional treatment. We developed an innovative ankle-knee-hip interlimb coordinated humanoid robot (ICT) to mitigate abnormal spasticity and synergistic patterns. Our study aimed to compare the effects of ICT combined conventional physical therapy (ICT-C) and conventional physical therapy and gait training (CPT-G) on abnormal spasticity, synergistic gait patterns, and gait biomechanics in 20 patients with acute hemiparesis. The interventions were provided in 60-min sessions, 7 days/week, for 2 weeks. ICT-C demonstrated superior effects to CPT-G in knee joint kinematics, hip extensor and ankle dorsiflexor spasticity, hip, knee, ankle active force, knee and ankle resistive force, hip, knee, and ankle stiffness. Concurrently, the abnormal gait synergy was reduced in the ICT-C group. Our novel findings provided promising evidence of the ICT benefits as a successful intervention for abnormal spasticity and synergistic gait impairments in patients with acute hemiparetic stroke.Trial Registration: Clinical Trials.gov identifier NCT03554642 (14/01/2020)
Constructing an AI Intelligent Strategy Algorithm for the Identification of Talented Rowers
Authors: Liu Jing-Wei , CHEN SHENG-HSIANG , Chen Che-Hsiu , Huang Tsung-Han 
Published: April 2021

Abstract
Taiwan’s rowing has achieved well performance in the Asian Games, but it has not in the Olympics. To get good results, in addition to the hard work and solid and effective training on weekdays, the qualification of the players is one of the key factors. Therefore, this research attempts to construct an artificial intelligence (AI) evaluation algorithm for rowing athletes to obtain advantages in the sports field, and can start from the athletes. The AI algorithm involves the hierarchical analysis method (AHP) is adopted to invite experts and scholars in the rowing field to answer the expert questionnaire. The TOPSIS (technique for order performance by similarity to ideal solution) method is then applied to calculate the ranking of material selection indicators, aiming to construct an evaluation model for rowers. The main research result shows that physicality is considered as the highest priority among the four main criteria of talent identification, following in a descending order by specialism, reaction and psychological elements. The propose model established by the most beneficial decision model for identification of talented rowers in the future.
Optical Properties of Composite Structure Based on ZnO Microneedles and Alq3 Thin Film
Authors: Karbovnyk Ivan , Sadoviy B. , Turko B. , Kostruba A. M. , Luchechko A. , Vasil’yev V.S. , Serkiz R. , Kulyk Y. , Klym H. , Khanna P.K. , Kukhta A. V. 
Published: April 2021

Abstract
The composite material based on ZnO microneedles and Alq3 thin film has been obtained. The photoluminescence study shows a tenfold enhancement in the band-edge UV emission (390 nm) of ZnO microneedles and 2x enhancement in visible emission of the hybrid composite, when excited by 266 nm laser beam. This enhancement can be explained by the interaction between ZnO and Alq3 molecules and the energy transfer from ZnO to Alq3 molecule.
Three-dimensional Non-destructive Visualization of Teeth Enamel Microcracks Using X-ray Micro-computed Tomography
Authors: Dumbryte Irma , Vailionis Arturas , Skliutas Edvinas , Juodkazis Saulius , Malinauskas Mangirdas 
Published: April 2021

Abstract
Although the topic of tooth fractures has been extensively analyzed in the dental literature, there is still insufficient information on the potential effect of enamel microcracks (EMCs) to the underlying tooth structures. For precise examination of tooth structure damage in the area of EMCs (i.e. whether it crosses the dentin-enamel junction (DEJ) and reaches dentin or pulp), volumetric (three-dimensional (3D)) evaluation of EMCs is necessary. The aim of this study was to present an X-ray micro-computed tomography (μCT) as a technique suitable for 3D non-destructive visualization and qualitative analysis of different severity teeth EMCs. Extracted human maxillary premolars were examined using a μCT instrument ZEISS Xradia 520 Versa. In order to separate (segment) cracks from the rest of the tooth a Deep Learning Tool was utilized within the ORS Dragonfly software. The scanning technique used allowed for the recognition and detection of EMCs that are not only visible on the outer surface but also those that are deeply buried inside the tooth. The 3D visualization combined with Deep Learning segmentation enabled evaluation of EMC dynamics as it extends from the cervical to the occlusal part of the tooth, and precise examination of EMC position with respect to the DEJ.
Greater Morphological and Primary Metabolic Adaptations in Roots Contribute to Phosphate-Deficiency Tolerance in the Bread Wheat Cultivar Kenong199
Authors: Zheng Lu , Karim Mohammad Rezaul , Hu Yin-Gang , Shen Renfang , Lan Ping 
Published: April 2021

Abstract
Background
Phosphate (Pi) deficiency severely affects crop growth and productivity, including wheat, therefore it is necessary to develop cultivars with enhanced Pi-deficiency tolerance. However, the underlying mechanism of Pi-deficiency tolerance in wheat is still elusive. Two contrasting wheat cultivars, low-Pi tolerant Kenong199 (KN199) and low-Pi sensitive Chinese Spring (CS) were used to reveal adaptations in response to Pi deficiency at the morphological, physiological, metabolic, and molecular levels.
Results
KN199 was more tolerant to Pi deficiency than CS with significantly increased root biomass and R/S ratio. Root traits, the total root length, total surface area, and total volume, were remarkably enhanced by Pi deficiency in KN199. The shoot soluble Pi and total P concentrations of KN199 were all significantly higher than these of CS, but not in roots. In KN199, high Pi level in shoots is a higher priority than that in roots under Pi deficiency. It was probably due to differentially regulation in the miR399-mediated signaling network between the shoots of the two cultivars. The Pi deficiency-induced root architecture adaptation in KN199 was attributed to the regulation of the hormone-mediated signaling (ethylene, gibberellin, and jasmonates). The expression of genes associated with root development and Pi uptake was enhanced in KN199. Some primary metabolites (amino acids and organic acids) were significantly accumulated in roots of KN199 under Pi deficiency.
Conclusions
The low-Pi tolerant wheat cultivar KN199 possessed greater morphological and primary metabolic adaptations in roots than CS under Pi deficiency. The adaption and the underlying molecular mechanism in wheat provide a better understanding of the Pi-deficiency tolerance and the strategies for improving Pi efficiency in wheat.
Estimation of Pore Volume Compressibility in Carbonate Reservoir Rocks based on a Classification
Authors: Moosavi Seyed Amin , Bakhtiari Hesam Aloki , Honarmand Javad 
Published: April 2021

Abstract
Taking a vast range of carbonate reservoir rock from Asmari and Bangestan formations in southern Iran basins, this study examined the petrographically classification, petrological and petrophysical characteristics, and their implications on the estimation of pore volume compressibility of the carbonate reservoirs. In the current study, a method is developed to classify the carbonate reservoir rocks based on the dominant factors which is involving in elastic property of pore volumes. In order to classifying, a number of 3702 thin sections were studied. Then, the pore volume compressibility of 200 core plugs corresponding to the range of classification parameters were obtained and quantified by a pre-proven equation. The results clearly show an acceptable narrow bandwidth between the upper and lower bound of estimations based on the studied classification. Furthermore, the estimation of pore compressibility-stress relationship was in a good agreement with the experimental observations. Also, the study shows that integrating the routine petrophysical properties are useful for estimation of stress related properties of pore volumes into carbonate reservoir rocks.
M2 Macrophage-Conditioned Medium Inhibits Intervertebral Disc Degeneration in a Tumor Necrosis Factor-α-rich Environment
Authors: Li Xiao-Chuan , Luo Shao-Jian , Fan Wu , Zhou Tian-Li , Huang Chun-Ming , Wang Maosheng 
Published: April 2021

Abstract
BackgroundInflammation is the primary pathological phenomenon associated with disc degeneration; accordingly, the inflammatory cytokine tumor necrosis factor (TNF-α) plays a crucial role in disc degeneration. M1 macrophages produce proinflammatory cytokines that facilitate the progression of intervertebral disc degeneration (IDD).However, the anti-inflammatory and regenerative effects of M2 macrophages on nucleus pulposus cells (NPCs) in IDD progression remain unknown. Here, we aimed to determine the role of M2 macrophages in IDD progression. MethodsM2 conditioned medium (M2CM) was harvested and purified from THP-1 cells; it was then used for culturing human NPCs and a mouse intervertebral disc (IVD) organ culture model. NPCs and IVD organ models were divided into the following three groups: group 1 was treated with 10% fetal bovine serum to actas the control, group 2 was treated with 10 ng/ml TNF-α, and group 3 was treated with 10 ng/ml TNF-α and M2CMto act as the co-culture group. After 3 to 14 days, cell proliferation (CCK-8 assay and western blotting for proliferation markers), extracellular matrix synthesis (quantitative polymerase chain reaction, western blotting, and immunofluorescence), apoptosis (TUNEL staining and western blotting), and NPC senescence (senescence-associated beta-galactosidase staining and western blotting) were assessed.ResultsCD206 and interleukin (IL)-10 levels were increased after 48 h of induction for M2 macrophages (both p<0.01). Cell proliferation was decreased in TNF-α-treated NPCs and was inhibited by M2CM co-culture. Moreover, TNF-α treatment enhanced the apoptosis, senescence, and expression of inflammatory factor-related genes, including IL-6, MMP-13, ADAMTS-4, and ADAMTS-5, whereas M2CM co-culture significantly reversed these effects. M2CM promoted aggrecan and collagen II synthesis but reduced collagen Iα1 levels in TNF-α treatment groups. Using our established three-dimensional murine IVD organ culture model, M2CM suppressed the inhibitory effect of TNF-α of the TNF-α-rich environment. Conclusions﻿Collectively, these results indicate that M2CM promotes cell proliferation and extracellular matrix synthesis and inhibits inflammation, apoptosis, and NPC senescence. This study therefore highlights the therapeutic potential of M2CM for IDD.
Strategic Nutrient Enhancement of Mustard Oil Seed Cake by Briquetting and Koji Fermentation for Ruminants Feed
Authors: Chakraborty Debosmita , Sarkar Nayanika , Agrahari Parul , Dutta Rishita , Singh Apurva Anand , JACOB SAMUEL 
Published: April 2021

Abstract
PurposeEdible oil industries are shifting to the increased production of cold pressed oils in order to preserve some of the vital nutrients the oil. Consequently, the seed cake residue would lack significant nutrients that are otherwise retained in the oils, thus making the quality of residue inferior when applying as cattle feed. MethodsIn this study, mustard oil seed cake (MOSC) was employed as the substrate and the nutritive and feed quality were enhanced using Koji strains viz., Aspergillus oryzae and Aspergillus niger, separately and suitable process parameters such as Solid: Liquid, pH, incubation time and inoculum quantity were optimized for the maximum nutritive enhancement of cold pressed MOSC. Changes in physico-chemical properties were analyzed by SEM, EDS, FTIR along with feed functional properties to analyze the quality. Briquetting of MOSC was employed for enhanced microbial encroachment.ResultFree amino acid (FAA) and reducing sugar (RS) were chosen as critical indicators of enrichment. A. oryzae resulted in 20.74 fold and 19.07 fold increase in FAA and RS respectively, whereas, A. niger resulted 13.24 fold and 3.04 fold increase. Critical parameters such as solid:liquid, pH, time and inoculum volume were selected. Briquetting resulted in efficient mycelia coverage as evident from SEM images and EDS analysis indicated enhancement in essential elements in the MOSC. Functional properties after fermentation indicated an effective transformation of MOSC. ConclusionUtilizing these seed cakes as cattle feed not only provide the required nutrition, but also helps in the efficient utilization of the residual waste oilseed cakes.
GIS-based Spatio-Temporal and Geostatistical Analysis of Groundwater Parameters of Lahore Region Pakistan and their Source Characterization
Authors: Ismail Sadia , Ahmed M Farooq 
Published: April 2021

Abstract
Assessment of groundwater quality is critical, especially in the areas where it is continuously deteriorating due to unplanned industrial growth. This study utilizes GIS-based spatio-temporal and geostatistics tools to characterize the groundwater quality parameters of Lahore region. For this purpose, a large data set of the groundwater quality parameters (for a period of 2005–2016) was obtained from the deep unconfined aquifers. GIS-based water quality index (WQI) and entropy water quality index (EWQI) models were prepared using 15 water quality parameters pH (power of hydrogen), TDS (Total dissolve solids), EC (Electrical conductivity), TH (Total hardness), Ca2+ (Calcium), Mg2+ (Magnesium), Na+ (Sodium), K+ (Potassium), Cl− (Chloride), As (Arsenic), F (Fluoride), Fe (Iron), HCO3− (Bicarbonate), NO3− (Nitrate), and SO42− (Sulfate). The data analysis exhibits that 12% of the groundwater samples fell within the category of poor quality that helped to identify the permanent epicenters of deteriorating water quality index in the study area. As per the entropy theory, Fe, NO3−, K, F, SO42− and As, are the major physicochemical parameters those influence groundwater quality. The spatio-temporal analysis of the large data set revealed an extreme behavior in pH values along the Hudiara drain, and overall high arsenic concentration levels in most of the study area. The geochemical analysis shows that the groundwater chemistry is strongly influence by subsurface soil water interaction. The research highlights the significance of using GIS-based spatio-temporal and geostatistical tools to analyze the large data sets of physicochemical parameters at regional level for the detailed source characterization studies.