bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of epizootic monitoring of natural foci of particularly dangerous infections common to humans and animals in Rostov Oblast
Authors: Lukshina E. Y. , Batashev V. V. , Kovalev E. V. , Karpushchenko G. V. , Balakhnova V. V. , Panasyuk N. V. , Alieva A. A. , Sidelnikov V. V. , Schwager M. M. , Polovinka N. V. , Polonsky A. V. , Logvin F. V. , Tutunkova N. G. , Noskov A. K. 
Published: December 2021

Objective: To analyze the results of epizootic monitoring of natural foci of particularly dangerous infections common to humans and animals in Rostov Oblast to establish their activity.Materials and Methods:The data of epizootic monitoring conducted by zoologists; the results of laboratory research of field material obtained in natural foci of infectious diseases. Descriptive, zoological, genetic, serological methods, and retrospective epidemiological analysis were used.Results: The results of the conducted epizootic monitoring showed the presence in Rostov Oblast of natural foci of particularly dangerous infectious diseases common to humans and animals. While the natural focus of the plague is in a depressed state and does not show activity, in the foci of tularemia, West Nile fever (WNF), Crimean hemorrhagic fever (CHF), ixodic tick-borne borreliosis (ITB), hemorrhagic fever with renal syndrome (HFRS), Q fever, Batai fever, California serogroups, Syndbis revealed the antigens of these pathogens in biological material obtained from small mammals and blood-sucking insects, which indicates the epizootic activity of these foci. In the natural foci of WNF, CHF, ITB, HFRS, cases of these disease among the population were recorded, which confirms the epidemic activity of these foci.Conclusion: The obtained results of epizootic monitoring over the period from 2008 to 2020 emphasize the relevance and necessity of continuing these studies in natural foci in Rostov Oblast.
Morbidity with temporary incapacity for work in the Southern Federal District of Russia. Selected indicators
Authors: Shastin A. S. , Tsepilova T. M. , Gazimova V. G. , Malykh O. L. , Gagarina M. S. 
Published: December 2021

Objective: To analyze the patterns of morbidity with temporary incapacity for work in the Southern Federal District of the Russian Federation.Materials and Methods: The object of the study is a unified interagency analytics platform. The subject of the research is the indicators of morbidity with temporary incapacity for work of the working population of the constituent entities of the Russian Federation of the Southern Federal District over 2005–2019: “The number of cases of temporary incapacity for work per 100 employees”, “The number of days of temporary incapacity for work per 100 employees”. The descriptive statistics methods were applied.Results: The studied statistical indicators of temporary incapacity for work reveal a steady positive trend in the morbidity rate of the working population in all the constituent entities of the Southern Federal District. From 2014 to 2015, there was a significant reduction in the indicators of temporary incapacity for work in all the constituent entities of the district. The indicators in all the studied constituent entities simultaneously declined, this decline being more prominent than in the previous 10 years. The data of the federal statistical monitoring does not represent an overall set of cases and days of temporary incapacity for work.Summary: It is deemed essential to amend Order of The Russian Federal Service for Statistics No. 723. All individuals and legal entities involved in medical activities for the examination of temporary incapacity for work in the relevant region must provide reports in accordance with Form 16-VN to the competent authorities of the constituent entities of the Russian Federation.
The functional state of the kallikrein-kinin and renin-angiotensin-aldosterone systems in patients with localized kidney cancer
Authors: Ushakova N. D. , Frantsiyants E. M. , Rozenko D. A. , Popova N. N. , Marykov E. A. , Rozenko A. D. 
Published: December 2021

Introduction. The development of a malignant tumor naturally affects renal function. During tumor formation, the renal tissue is destructed either by direct invasion into the parenchyma, or by mechanical change in the renal architecture caused by compression of the renal parenchyma, collecting ducts, tubules, and nephrons. In addition, a tumor can secrete biologically active substances, which have an indirect negative influence the functional state of the organ. Currently, it has been established that kallikrein-kinin and renin-angiotensin-aldosterone systems play an important role in the development of nephropathy of various genesis. At the same time, these systems' role in the development of renal function disorders in the setting of tumor damage has not yet been studied.Purpose of the study. To study changes in the components of the kallikrein-kinin and renin-angiotensin-aldosterone systems in the case of localized kidney cancer.Materials and methods. Forty-five patients diagnosed with T1N0M0 kidney cancer and 13 relatively healthy patients without cancer were examined. The determination of the components of the systems under study was carried out by the kinetic method after chromatography of blood plasma and urine using DEAE-Sephadex A-50 (Amersham Biosciences Corp., Sweden). The indices of angiotensin-1, renin, aldosterone, and cortisol were studied by an indirect method of radioimmunoassay. Statistical processing was carried out using Statistica 8.0 software (StatSoft Inc., IBM Corp., USA) by means of the Student-Fisher test (p < 0.05).Results. The development of kidney cancer is accompanied by a 2.3-fold increase in the activity of kallikrein and other trypsin proteases with a significant deficiency of their inhibitors (p < 0,05). Against this background, there is a 1.3-fold decrease in the cortisol/renin ratio from a 2.9-fold and 2.3-fold increase in the values of the renin/angiotensin-I and cortisol/angiotensin-I interaction ratios, respectively, compared with the normal values of these indicators (p < 0,05).Conclusions. Renal cell carcinoma is accompanied by trespassing of local metabolism with the formation of tubulointerstitial dysfunction and a shift of the proteinase-inhibitory balance towards proteolytic activation.
Impact of dietary supplements based on L-carnitine on free-radical processes in model systems
Authors: Galimov Sh. N. , Gromenko Yu. Yu. , Gromenko I. D. , Galimov K. Sh. , Gilyazova I. R. , Galimova E. F. 
Published: December 2021

Introduction. According to the results of numerous studies and meta-analyses, the effectiveness of male infertility therapy with micronutrients-antioxidants in various variants remains low, especially concerning the increase in live-birth rates and the incidence of clinical pregnancy. This may be due to both the empirical nature of such therapy with an imbalance of ejaculate redox systems, and an overdose of individual ingredients of antioxidant complexes.Purpose of the study. To evaluate the antioxidant activity of complex preparation based on L-carnitine for the treatment of male infertility in an experimental model system.Materials and methods. The dietary supplements «AndroDoz®» («Nizhfarm» JSC, Russian Federation) and «Proxeed® plus» (Sigma-Tau Pharmaceuticals Inc., Italy) were tested. The antioxidant properties of the preparations were determined in vitro by recording chemiluminescence in model systems generating reactive oxygen species using the «LKB-Wallac 1256 chemiluminometer» (Wallac Oy/PerkinElmer®, Finland). Chemiluminescence was evaluated by the light sum and the maximum amplitude of the glow, the antioxidant activity in the biological environment was studied when adding drugs to chicken yolk lipids similar to blood lipoprotein complexes.Results. The introduction of «AndroDoz®» and «Proxeed® plus» into the incubation medium in an amount comparable to the physiological level of L-carnitine in seminal plasma, inhibited the luminescence of the model system. At the same time, if «Proxeed® plus» almost completely inhibited the formation of radicals, then an equivalent dose of «AndroDoz®» reduced the intensity of chemiluminescence by 60%. Approximately in the same proportions, the preparations suppressed the intensity of lipid peroxidation processes in a model system with lipoprotein complexes similar to blood lipids, that is, the antioxidant activity was preserved in the biological environment. A decrease in the value of the chemiluminescence light sum was also found against the background of the use of these dietary supplements, which may indicate their protective effect on biological membranes, including subcellular structures of spermatozoa.Conclusion. The combined dietary supplements used in the study have a high antioxidant potential. The preparation «Proxeed® plus» can completely suppress the processes of lipoperoxidation with the possible development of a deficiency of free radicals that provide vital processes. The preparation «AndroDoz®» has a milder effect on free-radical phenomena probably due to a lower content of active ingredients and a balanced composition, which reduces the risk of complications in the form of an «antioxidant paradox» or reductive stress.
Lipidomic profile of seminal plasma in non-obstructive azoospermia with sperm maturation arrest
Authors: Gamidov S. I. , Shatylko T. V. , Tambiev A. Kh. , Tokareva A. O. , Chagovets V. V. , Bitsoev T. B. , Starodubtseva N. L. , Popova A. Yu. , Frankevich V. E. 
Published: December 2021

Introduction. The difference between obstructive and non-obstructive azoospermia with sperm maturation arrest is important for the choice of treatment tactics and adequate counseling of a married couple.Purpose of the study. The study aimed to assess the semen lipid profile in patients with sperm maturation arrest. Materials and methods. Samples of seminal plasma for lipid composition of 24 men with normozoospermia and 64 men with azoospermia were studied. Patients with azoospermia underwent microdissection testicular biopsy followed by the detection of testicular tissue pathology. Lipid extracts were analyzed by liquid chromatography with mass spectrometry. Lipid data were compared with the results of pathomorphological studies.Results. Comparison of two groups revealed a statistically significant concentration differences for 22 lipids detected in positive-ion mode and 11 lipids detected in negative-ion mode. Those lipids mainly belong to the classes hexosylceramides, sphingomyelins and phosphatidylcholines — simple ethers and oxidized lipids. In multivariate analysis, the following lipids were found to be statistically significant predictors of sperm maturation arrest: PC 16: 0_22: 6 lipid (β-coefficient: -0.73; 95% confidence interval (95% CI): -1.42 to -0.27; odds ratio (OR): 0.48; OR CI: 0.24 to 0.76; Wald's test: -2.58; p = 0.01), SM d20: 1/22:2 lipid (β-coefficient 4.96; 95% CI 2.29 to 9.13; OR: 142.31; OR CI: 9.90 to 9.22^103; Wald's test: 2.93; p = 0.003); PG 20:3_22: 6 lipid (β-coefficient 2.52; 95% CI 1.13 to 4.49; OR: 12.37; OR CI: 3.10 to 89.27; Wald's test: 3.02; p = 0.002); PC O- 16: 1/16:0 lipid (β-coefficient 1.96; 95% CI -4.12 to 0.27; OR: 0.14; OR CI: 0.02 to 0.76; Wald's test: -2.05; p = 0.04). The prediction model characteristics of sperm maturation arrest, obtained during cross-validation in the positiveion mode composed: sensitivity 91%, specificity 85%; in negative-ion mode: sensitivity 75%; specificity 81%.Conclusions. Even though early stages of spermatogenesis are equally preserved in both fertile men and men with homogeneous sperm maturation arrest, the semen in the studied group of patients differed in its lipid profile. Patients with non-obstructive azoospermia, associated with meiosis arrest, may have unique lipidomic characteristics of seminal plasma, which in the future will make it possible to differentiate various variants of severe male infertility using non-invasive methods.
Iodine-125 brachytherapy and robotic stereotactic radiotherapy — treatment options for patients with localized prostate cancer
Authors: Kiprijanov E. A. , Karnaukh P. A. , Vazhenin I. A. , Mozerova E. Ya. , Vazhenin A. V. 
Published: December 2021

Introduction. Modern radiological treatment options for patients with localized prostate cancer (PCa) have several advantages and allow achieving high rates of biochemical control.Purpose of the study. To compare immediate, proximate, and long-term results of low-dose Iodine-125 brachytherapy (I-125 BT) and robotic stereotactic radiotherapy (SBRT) in patients with localized low- and intermediate-risk PCa.Materials and methods. The study included 296 patients with localized low- and intermediate-risk PCa. I-125 BT and SBRT were performed in 208 and 88 patients, respectively. All patients with an intermediate-risk PCa were prescribed neoadjuvant androgen-deprivation therapy (NADT) with luteinizing hormone-releasing hormone analogues (LHRH) for 4-6 months. Only radiation treatment was used for low-risk PCa. As a result, two groups and four subgroups of patients were formed depending on the treatment method. The immediate, proximate, and long-term results of radiation treatment methods were studied in groups and subgroups.Results. No complications were recorded during brachytherapy I-125. Radiation cystitis grade 1 and radiation rectitis grade 1 were diagnosed after SBRT in 16.6% and 4.0% of cases, respectively. In the only I-125 BT subgroup, the PSA level during the year decreased from 8.3 to 1.1 ng/ml, in the SBRT subgroup — from 7.5 to 0.8 ng/ml. In the case of combined treatment, PSA decreased from 1.2 to 0.93 ng/ml and from 4.5 to 0.5 ng/ml, respectively. Changes in prostate volume, residual volume, and urinary quality (I-PSS) were comparable in all subgroups. Five-year cancer-specific survival and overall survival in the group of patients after SBRT was 100%, after I-125 BT — more than 90%.Conclusion. Radiation treatment options for patients with localized PCa are safe. Conducting NADT does not significantly reduce the prostate volume and does not affect the indicators of urodynamics. High rates of cancer-specific five-year survival rate testify to the effectiveness of the evaluated treatment options.
Surgical treatment of extended spongy urethral strictures in men: minimizing the risks of narrowing in the anastomotic zones between the buccal graft and the native urethra using the dorsal inlay technique
Authors: Mitusov V. V. , Kogan M. I. , Mirzaev Z. A. , Glukhov V. P. , Amirbekov B. G. 
Published: December 2021

Introduction. Currently, the most common method of treating extended urethral strictures is augmentation urethroplasty using oral mucosa grafts. Analysis of the long-term outcomes of this surgery type shows a high incidence of relapses and complications.Purpose of the study. To improve the outcomes of augmentation urethroplasty, in particular the dorsal inlay (Asopa) technique, in patients with extended spongy urethral strictures by minimizing the risk of recurrent strictures.Materials and methods. The study is based on an analysis of the surgery in 90 patients (aged 18-72 years) with extended spongy urethral strictures. Seventy patients (group I) underwent dorsal inlay augmentation urethroplasty according to the Asopa technique, and 20 patients (group II) — according to the author's modified technique. Statistical data analysis was carried out using the SPSS ver.26 software (SPSS Inc. Chicago, IL, USA).Results. A comparative analysis of the course of the early postoperative period showed a lower number of complications in group II patients compared to group I — 20.0% versus 34.3%, respectively. The recurrent strictures were registered for groups I and II in 18.8% and 5.6% of cases 6 months after surgery, respectively. The recurrent urethral narrowing was most often localized in the area of distal anastomosis between the buccal graft and the native urethra in patients from both groups.Conclusion. The modified dorsal inlay augmentation urethroplasty technique developed and implemented in clinical practice by increasing the internal urethral lumen in the areas of proximal and distal anastomosis between the buccal graft and the native spongy urethral body allows minimizing the risks of recurrent urethral narrowing after augmentation urethroplasty.
Tracking Subjective Sleep Quality and Mood With Mobile Sensing: Multiverse Study
Authors: Niemeijer Koen , Mestdagh Merijn , Kuppens Peter 
Published: December 2021

Background
Sleep influences moods and mood disorders. Existing methods for tracking the quality of people’s sleep are laborious and obtrusive. If a method were available that would allow effortless and unobtrusive tracking of sleep quality, it would mark a significant step toward obtaining sleep data for research and clinical applications.

Objective
Our goal was to evaluate the potential of mobile sensing data to obtain information about a person’s sleep quality. For this purpose, we investigated to what extent various automatically gathered mobile sensing features are capable of predicting (1) subjective sleep quality (SSQ), (2) negative affect (NA), and (3) depression; these variables are associated with objective sleep quality. Through a multiverse analysis, we examined how the predictive quality varied as a function of the selected sensor, the extracted feature, various preprocessing options, and the statistical prediction model.

Methods
We used data from a 2-week trial where we collected mobile sensing and experience sampling data from an initial sample of 60 participants. After data cleaning and removing participants with poor compliance, we retained 50 participants. Mobile sensing data involved the accelerometer, charging status, light sensor, physical activity, screen activity, and Wi-Fi status. Instructions were given to participants to keep their smartphone charged and connected to Wi-Fi at night. We constructed 1 model for every combination of multiverse parameters to evaluate their effects on each of the outcome variables. We evaluated the statistical models by applying them to training, validation, and test sets to prevent overfitting.

Results
Most models (on either of the outcome variables) were not informative on the validation set (ie, predicted R2≤0). However, our best models achieved R2 values of 0.658, 0.779, and 0.074 for SSQ, NA, and depression, respectively on the training set and R2 values of 0.348, 0.103, and 0.025, respectively on the test set.

Conclusions
The approach demonstrated in this paper has shown that different choices (eg, preprocessing choices, various statistical models, different features) lead to vastly different results that are bad and relatively good as well. Nevertheless, there were some promising results, particularly for SSQ, which warrant further research on this topic.
Impact of index card match method on the knowledge and attitudes about leucorrhoea among adolescent girls
Authors: Syaiful Yuanita , Fatmawati Lilis , Qomariah Siti Nur , Firdani Mafrukahtul 
Published: December 2021

Leucorrhoea is a reproductive health problem that often appears in adolescents. Girls between the ages of 12-16 are at high risk of leucorrhoea. The Index Card Match (ICM) method is recognized as an effective preventive effort of the adolescent health education. This research aimed to discover the impact of the ICM method on the knowledge and attitudes about leucorrhoea among adolescent girls and prove the ICM method’s effectivity between the treatment and control groups. This study used a quasi-experimental design with a pre–post-test and control group. The population of this research was 40 adolescent girls. The sample included as many as 32 respondents using purposive sampling who were then divided into 2 groups: treatment and control, with each group consisting of 16 respondents. The independent variable was health education using the ICM method. The dependent variables were knowledge and attitude. The instruments used a questionnaire of knowledge and attitude, index card match, leaflet, and event activity unit. Data analysis used a paired T-test and the independent T-test with the significance set as p<0.05. The results of the paired sample T-test in the treatment group obtained the value of p = 0.000 (p <0.05), which means that after the ICM method there was significant improvement in the knowledge about leucorrhoea among the adolescent girls. The independent T test obtained p value = 0.000 (p <0.05), which indicated there was significant difference in knowledge between the treatment and control groups. The paired T test in the treatment group obtained the value of p = 0.000 (p <0.05), which means that after the ICM method there was significant change in the attitudes about leucorrhoea among the adolescent girls. The independent T test obtained the value of p = 0.000 (p <0.05), which indicated there was a significant difference in post-test attitudes between the treatment and control groups. Health education with the index card match method was one of the effective learning methods that could be accepted well by the respondents. As a result, the respondents could improve their learning about leucorrhoea.
Przejawy i uwarunkowania tożsamości negatywnej u młodzieży w okresie wczesnej adolescencji z lekką niepełnosprawnością intelektualną
Authors: Bąbka Jarosław 
Published: December 2021

W artykule podjęto problem tożsamości negatywnej, wyrażającej się w zachowaniach ryzykownych u młodzieży w okresie wczesnej adolescencji. Tożsamość negatywna może mieć u dorastających charakter przejściowy, ale może też zostać utrwalona na skutek różnych czynników, co w dalszej perspektywie prowadzi do negacji norm kulturowych i prawnych oraz przyswajania kultury przestępczej. Kontekst teoretycznych rozważań stanowi koncepcja, socjalizacji w opracowaniu Klausa Hurelmana, ujęcie psychospołecznego rozwoju ego według Erica H. Eriksona, koncepcja społecznego środowiska rozwoju Urie Bronfenbrennera, a także rozważania na temat ponowoczesności Zygmunta Baumana i społeczeństwa ryzyka Urlicha Becka. Analiza i interpretacja wyników badań jakościowych pozwoliła potwierdzić występowanie zachowań trudnych u adolescentów z niepełnosprawnością intelektualną oraz zidentyfikować cztery grupy czynników ryzyka tożsamości negatywnej: 1) dotyczących dysfunkcjonalności środowiska rodzinnego, (2) związanych ze szkołą oraz nieadekwatną ofertą edukacyjną, (3) odnoszących się do niepełnosprawności i reakcji na nią otoczenia społecznego, (4) uwzględniających przemiany społeczno-kulturowe.
La cooperativa común: una alternativa de Spin-Off acádemica
Authors: Pacheco-Carrascal Marilce , Navarro-Claro Genny Torcoroma , Arevalo-Ascanio Jose Gregorio 
Published: December 2021

La Facultad de Ciencias Administrativas y Económicas de la Universidad Francisco de Paula Santander Ocaña, fundamentada en su misión, propende por la formación integral y el crecimiento personal del recurso humano, orientándolo hacia los procesos de desarrollo empresarial del entorno a través de la academia, la investigación y la proyección social, ha ejecutado una serie de actividades y proyectos procurando la participación de todos los estamentos universitarios y la comunidad en general. Bajo esta concepción, se propuso constituir una cooperativa multiactiva modalidad Spin-off, que transforme las actividades académicas, investigativas y de extensión en proyectos de gran valor agregado, que favorezcan procesos de innovación y emprendimiento desde la academia. La metodología utilizada fue participativa, donde la comunidad universitaria y los cuerpos directivos, conocieron la propuesta, su organización y proyección, comprometiéndose a la asignación de recursos. La Cooperativa como Spin-off es una iniciativa empresarial promovida por investigadores del Grupo GIDSE, con miras a desarrollar procesos, productos y servicios a partir de la investigación aplicada para el desarrollo de nuevas tecnologías, la creación de empleo de calidad, la capacidad de generar un alto valor añadido en la actividad económica y la aportación al desarrollo local y regional.