bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiative neutrino masses, lepton flavor mixing and muon g − 2 in a leptoquark model
Authors: Zhang Di 
Published: July 2021

Abstract
We propose a leptoquark model with two scalar leptoquarks $$ {S}_1\left(\overline{3},1,\frac{1}{3}\right) $$

S
1

3
¯

1

1
3

and $$ {\tilde{R}}_2\left(3,2,\frac{1}{6}\right) $$

R
˜

2

3
2

1
6

to give a combined explanation of neutrino masses, lepton flavor mixing and the anomaly of muon g − 2, satisfying the constraints from the radiative decays of charged leptons. The neutrino masses are generated via one-loop corrections resulting from a mixing between S1 and $$ {\tilde{R}}_2 $$

R
˜

2

. With a set of specific textures for the leptoquark Yukawa coupling matrices, the neutrino mass matrix possesses an approximate μ-τ reflection symmetry with (Mν)ee = 0 only in favor of the normal neutrino mass ordering. We show that this model can successfully explain the anomaly of muon g − 2 and current experimental neutrino oscillation data under the constraints from the radiative decays of charged leptons.
Higher-derivative heterotic Double Field Theory and classical double copy
Authors: Lescano Eric , Rodríguez Jesús A. 
Published: July 2021

Abstract
The generalized Kerr-Schild ansatz (GKSA) is a powerful tool for constructing exact solutions in Double Field Theory (DFT). In this paper we focus in the heterotic formulation of DFT, considering up to four-derivative terms in the action principle, while the field content is perturbed by the GKSA. We study the inclusion of the generalized version of the Green-Schwarz mechanism to this setup, in order to reproduce the low energy effective heterotic supergravity upon parametrization. This formalism reproduces higher-derivative heterotic background solutions where the metric tensor and Kalb-Ramond field are perturbed by a pair of null vectors. Next we study higher-derivative contributions to the classical double copy structure. After a suitable identification of the null vectors with a pair of U(1) gauge fields, the dynamics is given by a pair of Maxwell equations plus higher derivative corrections in agreement with the KLT relation.
A Penrose limit for type IIB AdS6 solutions
Authors: Gutperle Michael , Klein Nicholas 
Published: July 2021

Abstract
In this paper a Penrose limit is constructed for type IIB AdS6× S2× Σ supergravity solutions. These solutions are dual to five dimensional SCFTs related to (p,q) five brane webs, which can often be described in terms of long quiver gauge theories. The null geodesic from which the Penrose limit is constructed is localized at a unique point on the two dimensional Riemann surface Σ, where the AdS6 and S2 metric factors are extremal. The resulting pp-wave spacetime takes a universal form. The world sheet action of the Green-Schwarz string is quadratic in the light cone gauge and the spectrum of string excitations is obtained.
Simultaneous quantification of trimethylamine N-oxide, trimethylamine, choline, betaine, creatinine, and propionyl-, acetyl-, and l-carnitine in clinical and food samples using HILIC-LC-MS
Authors: Hefni Mohammed E , Bergström Maria , Lennqvist Torbjörn , Fagerström Cecilia , Witthöft Cornelia M 
Published: July 2021

AbstractTrimethylamine-N-oxide (TMAO), a microbiome-derived metabolite from the metabolism of choline, betaine, and carnitines, is associated to adverse cardiovascular outcomes. A method suitable for routine quantification of TMAO and its precursors (trimethylamine (TMA), choline, betaine, creatinine, and propionyl-, acetyl-, and l-carnitine) in clinical and food samples has been developed based on LC-MS. TMA was successfully derivatized using iodoacetonitrile, and no cross-reactions with TMAO or the other methylamines were detected. Extraction from clinical samples (plasma and urine) was performed after protein precipitation using acetonitrile:methanol. For food samples (meatballs and eggs), water extraction was shown to be sufficient, but acid hydrolysis was required to release bound choline before extraction. Baseline separation of the methylamines was achieved using a neutral HILIC column and a mobile phase consisting of 25 mmol/L ammonium formate in water:ACN (30:70). Quantification was performed by MS using external calibration and isotopic labelled internal standards. The assay proved suitable for both clinical and food samples and was linear from ≈ 0.1 up to 200 μmol/L for all methylamines except for TMA and TMAO, which were linear up to 100 μmol/L. Recoveries were 91–107% in clinical samples and 76–98% in food samples. The interday (n=8, four duplicate analysis) CVs were below 9% for all metabolites in clinical and food samples. The method was applied successfully to determine the methylamine concentrations in plasma and urine from the subjects participating in an intervention trial (n=10) to determine the effect of animal food ingestion on methylamine concentrations.
Graphical abstract
Combined simulation and optimization framework for irrigation scheduling in agriculture fields
Authors: Fontanet Mireia , Fernàndez-Garcia Daniel , Rodrigo Gema , Ferrer Francesc , Villar Josep Maria 
Published: July 2021

AbstractIn the context of growing evidence of climate change and the fact that agriculture uses about 70% of all the water available for irrigation in semi-arid areas, there is an increasing probability of water scarcity scenarios. Water irrigation optimization is, therefore, one of the main goals of researchers and stakeholders involved in irrigated agriculture. Irrigation scheduling is often conducted based on simple water requirement calculations without accounting for the strong link between water movement in the root zone, soil–water–crop productivity and irrigation expenses. In this work, we present a combined simulation and optimization framework aimed at estimating irrigation parameters that maximize the crop net margin. The simulation component couples the movement of water in a variably saturated porous media driven by irrigation with crop water uptake and crop yields. The optimization component assures maximum gain with minimum cost of crop production during a growing season. An application of the method demonstrates that an optimal solution exists and substantially differs from traditional methods. In contrast to traditional methods, results show that the optimal irrigation scheduling solution prevents water logging and provides a more constant value of water content during the entire growing season within the root zone. As a result, in this case, the crop net margin cost exhibits a substantial increase with respect to the traditional method. The optimal irrigation scheduling solution is also shown to strongly depend on the particular soil hydraulic properties of the given field site.
Comorbidities, substance abuse, weight and age are independent risk factors for postoperative complications following operation for proximal humerus fractures: a retrospective analysis of 1109 patients
Authors: Henkelmann Ralf , Theopold Jan , Kitsche Jonas , Link Paul-Vincent , Mende Meinhard , Hepp Pierre 
Published: July 2021

Abstract
Introduction
This study aimed to investigate the influence of epidemiologic parameters on complications that needed operative revision of operatively treated proximal humerus fractures.

Methods
We performed a retrospective single-center study in a level 1 trauma center. We included all patients with operatively treated proximal humerus fractures from January 1 2005 to December 31 2015. We characterized our cohort and subgroup using descriptive statistics. The primary outcome was postoperative complications. For this purpose, postoperative complications were defined in advance, an operative revision was necessary on a general rule. The secondary outcome was a model of the risk factors for complications created with multiple logistic regression.

Results
We included 1109 patients. The average age was 67.2 years (± 16.4), and 71.4% of the fractures occurred in women. A total of 644 patients (58.1%) had between one to three comorbidities, and 27.8% had four or more. The fracture morphology was as follows: 3 part 41.8%, 4 part 26.9%, 2 part 24.3%, and dislocation fracture 6.7%. Complications occurred in 150 patients (13.5%). The number of comorbidities [odds ratio (OR) 2.85, p < 0.01], body weight (OR 1.15, p = 0.02), and substance abuse (OR 1.82, p = 0.04) significantly correlated with the risk of complications. We achieved a sensitivity of 48% and a specificity of 74% for the variables body weight, substance abuse, age, and comorbidities

Conclusion
The epidemiologic parameters, comorbidities, substance abuse, weight, and age are independent risk factors for complications. If these factors are present, one can predict a postoperative complication requiring surgical revision with low sensitivity and moderate specificity. Therefore, concerning the high number of multi-morbid patients with proximal humerus fractures, an increased postoperative complication rate can be expected.

Level of evidence
Level of evidence IV
Informationen zu bipolaren Störungen und Darstellungen in Film und Literatur
Authors: Erfurth Andreas , Michael Nikolaus , Roestel Cornelia , Sachs Gabriele 
Published: July 2021

ZusammenfassungHiermit veröffentlicht psychopraxis.neuropraxis die dritte Tranche eines Psychoedukationsprogramms mit 8 Modulen. Vorgestellt wird eine offene Stunde, in der für das Konzept von Selbsthilfegruppen geworben wird und Anregungen zu Büchern mit Informationen gegeben werden, auch zu Darstellungen affektiver Störungen in Literatur und Film. In einem weiteren Modul lernen die Teilnehmer die retrospektive Life-Chart kennen. Durch die Verknüpfung von retrospektiver mit prospektiver Life-Chart entsteht eine lückenlose Erfassung des Verlaufes und seiner Determinanten durch die bipolare Person.
Effects of provider incentives on dental X-raying in NHS Scotland: what happens if patients switch providers?
Authors: Kalmus Olivier , Chalkley Martin , Listl Stefan 
Published: July 2021

Abstract
Background
In many market settings individuals are encouraged to switch health care providers as a means of ensuring more competition. Switching may have a potentially undesirable side effect of increasing unnecessary treatment. Focusing on the most common source of medical radiation (dental X-rays), the purpose of this study was to assess whether, upon switching dentist, X-ray exposure increases depending on the type of provider payment.

Methods
The analysis used longitudinal data from 2005 to 2016 covering a 5% random sample of the Scottish adult population covered by the National Health Service (NHS). Multiple fixed-effects panel regression analyses were employed to determine the correlation of provider remuneration with patients’ likelihood of receiving an X-ray upon switching to a new dentist other things equal. A broad set of covariates including a patient’s copayment status was controlled for.

Results
Upon switching to a dentist who was paid fee-for-service, patients had a by 9.6%-points (95% CI 7.4–11.8%) higher probability of receiving an X-ray, compared to switching to a salaried dentist. Results were robust when accounting for patient exemption status, as well as unobserved patient and dentist characteristics.

Conclusions
In comparison to staying with the same dentist, patients may be exposed to substantially more X-rays upon switching to a dentist who is paid fee-for-service. There may need to be better guidance and regulation to protect the health of those who have to switch provider due to moving and greater caution in advocating voluntary switching.
Learning Interaction Kernels in Stochastic Systems of Interacting Particles from Multiple Trajectories
Authors: Lu Fei , Maggioni Mauro , Tang Sui 
Published: July 2021

AbstractWe consider stochastic systems of interacting particles or agents, with dynamics determined by an interaction kernel, which only depends on pairwise distances. We study the problem of inferring this interaction kernel from observations of the positions of the particles, in either continuous or discrete time, along multiple independent trajectories. We introduce a nonparametric inference approach to this inverse problem, based on a regularized maximum likelihood estimator constrained to suitable hypothesis spaces adaptive to data. We show that a coercivity condition enables us to control the condition number of this problem and prove the consistency of our estimator, and that in fact it converges at a near-optimal learning rate, equal to the min–max rate of one-dimensional nonparametric regression. In particular, this rate is independent of the dimension of the state space, which is typically very high. We also analyze the discretization errors in the case of discrete-time observations, showing that it is of order 1/2 in terms of the time spacings between observations. This term, when large, dominates the sampling error and the approximation error, preventing convergence of the estimator. Finally, we exhibit an efficient parallel algorithm to construct the estimator from data, and we demonstrate the effectiveness of our algorithm with numerical tests on prototype systems including stochastic opinion dynamics and a Lennard-Jones model.
Serum caspase-cleaved cytokeratin-18 fragment as a prognostic biomarker in hematological patients with febrile neutropenia
Authors: Intke Carina , Korpelainen Sini , Lappalainen Marika , Vänskä Matti , Hämäläinen Sari , Pulkki Kari , Jantunen Esa , Juutilainen Auni , Purhonen Anna-Kaisa 
Published: July 2021

AbstractThe study aim was to determine the benefit of the measurement of serum caspase-cleaved cytokeratin-18 (CK-18) fragment as a prognostic marker of febrile neutropenia (FN) in hematological patients. The study population consisted of 86 consecutive patients with FN who received intensive chemotherapy for hematological malignancy at the adult hematology ward of Kuopio University Hospital. Twenty-three patients (27%) had acute myeloid leukemia, and 63 patients (73%) were autologous stem cell transplant recipients. Serum caspase-cleaved CK-18 fragment M30, C-reactive protein (CRP) and procalcitonin (PCT) were measured at the onset of FN (d0), on day 1 (d1), and on day 2 (d2). Eight patients (9%) developed severe sepsis, including three patients with septic shock. Eighteen patients (21%) had a blood culture-positive infection. Serum CK-18 fragment peaked on the first day after fever onset in patients with severe sepsis. Higher CK-18 level was associated with severe sepsis, intensive care unit treatment, and fatal outcome, but not with blood culture positivity. In ROC curve analysis, d1 serum CK-18 fragment predicted severe sepsis with an area under the curve (AUC) of 0.767, CRP with an AUC of 0.764, and PCT with an AUC of 0.731. On d2, the best predictive capacity was observed for CRP with an AUC of 0.832. The optimal cutoff of caspase-cleaved CK-18 fragment M30 for predicting severe sepsis was 205 U/L on d1. In hematological patients, serum CK-18 fragment was found to be a potential prognostic marker of severe sepsis at early stages of FN.
Klinische Charakteristika und Lebensqualität beim Dravet-Syndrom: Ergebnisse der deutschen Kohorte des „Dravet syndrome caregiver survey“ (DISCUSS)
Authors: Strzelczyk A. , Lagae L. , Kurlemann G. , Flege S. , Bast T. , Polster T. , Pringsheim M. , von Spiczak S. , Hipp P. , Schubert-Bast S. 
Published: July 2021

Zusammenfassung
Hintergrund
Das Dravet-Syndrom (DS) ist ein seltenes, in der frühen Kindheit beginnendes, therapierefraktäres Epilepsiesyndrom, das mit einer hohen Morbidität und Mortalität verbunden ist.

Fragestellung
Ziele der Querschnittsstudie „Dravet syndrome caregiver survey“ (DISCUSS) sind die Identifizierung und Beschreibung der Faktoren, die einen Einfluss auf die Krankheitslast von Patienten mit DS und ihre Betreuer haben können. Die Ergebnisse der deutschen Kohorte werden vorgestellt.

Material und Methoden
Die Datenerhebung erfolgte durch eine anonyme Befragung von Eltern. Die Ergebnisse wurden für die verschiedenen Altersgruppen statistisch ausgewertet.

Ergebnisse
Der Fragebogen wurde von 68 Eltern der DS-Patienten mit einem durchschnittlichen Alter von 10 Jahren (Median: 9, Spanne: 1–26) ausgefüllt. Nur 3 Patienten (4,4 %) waren in den letzten 3 Monaten anfallsfrei. Insgesamt hatten 97 % der Patienten, die älter als 5 Jahre waren (n = 45), mindestens eine Komorbidität. Die zum Befragungszeitpunkt am häufigsten eingenommenen Antiepileptika waren Valproat, Kaliumbromid, Stiripentol, Clobazam und Topiramat. In der Vergangenheit wurden Natriumkanalblocker, Phenobarbital und Levetiracetam eingesetzt, aktuell fanden diese Antiepileptika nur selten Verwendung. Die Lebensqualität der Patienten war niedriger als die der Allgemeinbevölkerung. Die Erkrankung eines Familienmitglieds mit DS beeinflusst Eltern und Geschwister in hohem Maße.

Diskussion
Trotz individueller Kombinationstherapien sind die meisten Patienten mit DS nicht anfallsfrei. Insgesamt hat sich der Einsatz von beim DS wenig wirksamer Medikamente und der kontraindizierten Natriumkanalblocker zugunsten von wirksameren Medikamenten verschoben. Neue Therapie- und Versorgungskonzepte sind notwendig, um die Versorgung der Patienten mit DS zu verbessern und Eltern und Geschwister zu entlasten.
Non-intrusive data-driven ROM framework for hemodynamics problems
Authors: Girfoglio M. , Scandurra L. , Ballarin F. , Infantino G. , Nicolo F. , Montalto A. , Rozza G. , Scrofani R. , Comisso M. , Musumeci F. 
Published: July 2021

AbstractReduced order modeling (ROM) techniques are numerical methods that approximate the solution of parametric partial differential equation (PED) by properly combining the high-fidelity solutions of the problem obtained for several configurations, i.e. for several properly chosen values of the physical/geometrical parameters characterizing the problem. By starting from a database of high-fidelity solutions related to a certain values of the parameters, we apply the proper orthogonal decomposition with interpolation (PODI) and then reconstruct the variables of interest for new values of the parameters, i.e. different values from the ones included in the database. Furthermore, we present a preliminary web application through which one can run the ROM with a very user-friendly approach, without the need of having expertise in the numerical analysis and scientific computing field. The case study we have chosen to test the efficiency of our algorithm is represented by the aortic blood flow pattern in presence of a left ventricular (LVAD) assist device when varying the pump flow rate.
A topological extension of movement primitives for curvature modulation and sampling of robot motion
Authors: Colomé Adrià , Torras Carme 
Published: July 2021

AbstractThis paper proposes to enrich robot motion data with trajectory curvature information. To do so, we use an approximate implementation of a topological feature namedwrithe, which measures the curling of a closed curve around itself, and its analog feature for two closed curves, namely thelinking number. Despite these features have been established for closed curves, their definition allows for a discrete calculation that is well-defined for non-closed curves and can thus provide information about how much a robot trajectory is curling around a line in space. Such lines can be predefined by a user, observed by vision or, in our case, inferred as virtual lines in space around which the robot motion is curling. We use these topological features to augment the data of a trajectory encapsulated as a Movement Primitive (MP). We propose a method to determine how many virtual segments best characterize a trajectory and then find such segments. This results in a generative model that permits modulating curvature to generate new samples, while still staying within the dataset distribution and being able to adapt to contextual variables.
Contrasting wolf responses to different paved roads and traffic volume levels
Authors: Dennehy Emma , Llaneza Luis , López-Bao José Vicente 
Published: July 2021

AbstractIn some regions of the world, large carnivores, such as wolves, persist in landscapes with dense networks of paved roads. However, beyond the general impacts of roads on wildlife, we still lack information on carnivore responses to different types of roads and traffic volume levels. Using wolves in NW Spain as a case study, we show how wolves respond differently to paved road classes depending on road size, speed limit and traffic volume. All wolves evaluated (25 GPS collared wolves) crossed paved roads. Overall, during 3,915 sampling days, we recorded 29,859 wolf crossings. Wolf crossings of all paved road classes were recorded at a mean rate of 0.022 crossings/day/km (95% CI 0.016–0.027). Wolves crossed low speed and low traffic volume roads more frequently, and more often during the night, in order to lessen the chances of encountering traffic. We found mortality to be highest on roads with high speed and high traffic volume. How wolves interact with paved roads should be considered in landscape planning strategies in order to guarantee wolf long-term persistence in human-dominated landscapes. In our case, our results support an increasing focus on primary roads (class II) to identify segments of these roads where road mitigation efforts should be prioritised. Our study also highlights the importance of considering paved road classes when studying the impact of roads on wildlife.
Biodiversity conservation in climate change driven transient communities
Authors: Schippers Peter , Abarca Euridice Leyequien , Verboom Jana , Wamelink G. W. Wieger , Vos Claire C. , de Boer Willem F. , Harvey Jeffrey A. , Essens Tijl , Grashof-Bokdam Carla J. , WallisDeVries Michiel F. , Cobben Marleen M. P. 
Published: July 2021

Abstract
Species responding differently to climate change form ‘transient communities’, communities with constantly changing species composition due to colonization and extinction events. Our goal is to disentangle the mechanisms of response to climate change for terrestrial species in these transient communities and explore the consequences for biodiversity conservation. We review spatial escape and local adaptation of species dealing with climate change from evolutionary and ecological perspectives. From these we derive species vulnerability and management options to mitigate effects of climate change. From the perspective of transient communities, conservation management should scale up static single species approaches and focus on community dynamics and species interdependency, while considering species vulnerability and their importance for the community. Spatially explicit and frequent monitoring is vital for assessing the change in communities and distribution of species. We review management options such as: increasing connectivity and landscape resilience, assisted colonization, and species protection priority in the context of transient communities.