bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finding disease outbreak locations from human mobility data
Authors: Schlosser Frank , Brockmann Dirk 
Published: October 2021

AbstractFinding the origin location of an infectious disease outbreak quickly is crucial in mitigating its further dissemination. Current methods to identify outbreak locations early on rely on interviewing affected individuals and correlating their movements, which is a manual, time-consuming, and error-prone process. Other methods such as contact tracing, genomic sequencing or theoretical models of epidemic spread offer help, but they are not applicable at the onset of an outbreak as they require highly processed information or established transmission chains. Digital data sources such as mobile phones offer new ways to find outbreak sources in an automated way. Here, we propose a novel method to determine outbreak origins from geolocated movement data of individuals affected by the outbreak. Our algorithm scans movement trajectories for shared locations and identifies the outbreak origin as the most dominant among them. We test the method using various empirical and synthetic datasets, and demonstrate that it is able to single out the true outbreak location with high accuracy, requiring only data of $N=4$
N
=
4
individuals. The method can be applied to scenarios with multiple outbreak locations, and is even able to estimate the number of outbreak sources if unknown, while being robust to noise. Our method is the first to offer a reliable, accurate out-of-the-box approach to identify outbreak locations in the initial phase of an outbreak. It can be easily and quickly applied in a crisis situation, improving on previous manual approaches. The method is not only applicable in the context of disease outbreaks, but can be used to find shared locations in movement data in other contexts as well.
Emotions in online rumor diffusion
Authors: Pröllochs Nicolas , Bär Dominik , Feuerriegel Stefan 
Published: October 2021

AbstractEmotions are regarded as a dominant driver of human behavior, and yet their role in online rumor diffusion is largely unexplored. In this study, we empirically study the extent to which emotions explain the diffusion of online rumors. We analyze a large-scale sample of 107,014 online rumors from Twitter, as well as their cascades. For each rumor, the embedded emotions were measured based on eight so-called basic emotions from Plutchik’s wheel of emotions (i.e., anticipation–surprise, anger–fear, trust–disgust, joy–sadness). We then estimated using a generalized linear regression model how emotions are associated with the spread of online rumors in terms of (1) cascade size, (2) cascade lifetime, and (3) structural virality. Our results suggest that rumors conveying anticipation, anger, and trust generate more reshares, spread over longer time horizons, and become more viral. In contrast, a smaller size, lifetime, and virality is found for surprise, fear, and disgust. We further study how the presence of 24 dyadic emotional interactions (i.e., feelings composed of two emotions) is associated with diffusion dynamics. Here, we find that rumors cascades with high degrees of aggressiveness are larger in size, longer-lived, and more viral. Altogether, emotions embedded in online rumors are important determinants of the spreading dynamics.
Identifying Informatively Easy and Informatively Hard Concepts
Authors: Wiegand R. Paul , Bucci Anthony , Kumar Amruth N. , Albert Jennifer , Gaspar Alessio 
Published: October 2021

In this article, we leverage ideas from the theory of coevolutionary computation to analyze interactions of students with problems. We introduce the idea of
informatively
easy or hard concepts. Our approach is different from more traditional analyses of problem difficulty such as item analysis in the sense that we consider Pareto dominance relationships within the multidimensional structure of student–problem performance data rather than average performance measures. This method allows us to uncover not just the problems on which students are struggling but also the variety of difficulties different students face. Our approach is to apply methods from the Dimension Extraction Coevolutionary Algorithm to analyze problem-solving logs of students generated when they use an online software tutoring suite for introductory computer programming called
problets
. The results of our analysis not only have implications for how to scale up and improve adaptive tutoring software but also have the promise of contributing to the identification of common misconceptions held by students and thus, eventually, to the construction of a concept inventory for introductory programming.
Glioblastoma Cell–Derived lncRNA-Containing Exosomes Induce Microglia to Produce Complement C5, Promoting Chemotherapy Resistance
Authors: Li Ziwei , Meng Xiangqi , Wu Pengfei , Zha Caijun , Han Bo , Li Lulu , Sun Nan , Qi Tengfei , Qin Jie , Zhang Yangong , Tian Kaifu , Li Shupeng , Yang Changxiao , Ren Lejia , Ming Jianguang , Wang Pandeng , Song Yifei , Jiang Chuanlu , Cai Jinquan 
Published: October 2021

Abstract

Glioblastoma (GBM), the most common malignant primary brain cancer in adults, nearly always becomes resistant to current treatments, including the chemotherapeutic temozolomide (TMZ). The long noncoding RNA (lncRNA) TMZ-associated lncRNA in GBM recurrence (lnc-TALC) promotes GBM resistance to TMZ. Exosomes can release biochemical cargo into the tumor microenvironment (TME) or transfer their contents, including lncRNAs, to other cells as a form of intercellular communication. In this study, we found that lnc-TALC could be incorporated into exosomes and transmitted to tumor-associated macrophages (TAM) and could promote M2 polarization of the microglia. This M2 polarization correlated with secretion of the complement components C5/C5a, which occurred downstream of lnc-TALC binding to ENO1 to promote the phosphorylation of p38 MAPK. In addition, C5 promoted the repair of TMZ-induced DNA damage, leading to chemotherapy resistance, and C5a-targeted immunotherapy showed improved efficacy that limited lnc-TALC–mediated TMZ resistance. Our results reveal that exosome-transmitted lnc-TALC could remodel the GBM microenvironment and reduce tumor sensitivity to TMZ chemotherapy, indicating that the lnc-TALC–mediated cross-talk between GBM cells and microglia could attenuate chemotherapy efficacy and pointing to potential combination therapy strategies to overcome TMZ resistance in GBM.
See related Spotlight by Zhao and Xie, p. 1372.
Rejuvenating Effector/Exhausted CAR T Cells to Stem Cell Memory–Like CAR T Cells By Resting Them in the Presence of CXCL12 and the NOTCH Ligand
Authors: Ando Makoto , Kondo Taisuke , Tomisato Wataru , Ito Minako , Shichino Shigeyuki , Srirat Tanakorn , Mise-Omata Setsuko , Nakagawara Kensuke , Yoshimura Akihiko 
Published: October 2021

T cells with a stem cell memory (TSCM) phenotype provide long-term and potent antitumor effects for T-cell transfer therapies. Although various methods for the induction of TSCM-like cells in vitro have been reported, few methods generate TSCM-like cells from effector/exhausted T cells. We have reported that coculture with the Notch ligand–expressing OP9 stromal cells induces TSCM-like (iTSCM) cells. Here, we established a feeder-free culture system to improve iTSCM cell generation from expanded chimeric antigen receptor (CAR)-expressing T cells; culturing CAR T cells in the presence of IL7, CXCL12, IGF-I, and the Notch ligand, hDLL1. Feeder-free CAR-iTSCM cells showed the expression of cell surface markers and genes similar to that of OP9-hDLL1 feeder cell–induced CAR-iTSCM cells, including the elevated expression of SCM-associated genes, TCF7, LEF1, and BCL6, and reduced expression of exhaustion-associated genes like LAG3, TOX, and NR4A1. Feeder-free CAR-iTSCM cells showed higher proliferative capacity depending on oxidative phosphorylation and exhibited higher IL2 production and stronger antitumor activity in vivo than feeder cell–induced CAR-iTSCM cells. Our feeder-free culture system represents a way to rejuvenate effector/exhausted CAR T cells to SCM-like CAR T cells.

Significance:
Resting CAR T cells with our defined factors reprograms exhausted state to SCM-like state and enables development of improved CAR T-cell therapy.
Heritage Speakers’ Production of the Spanish Voiced Palatal Obstruent /ʝ/: A Closer Look at Orthography and Universal Phonetic Principles
Authors: Repiso-Puigdelliura Gemma , Benvenuti Isabel , Kim Ji Young 
Published: October 2021

Abstract
The Spanish voiced palatal obstruent /ʝ/ is orthographically represented as ⟨y⟩ or ⟨ll⟩. The most closely related sound in English is /j/, which is often written with ⟨y⟩, but produced with weaker constriction compared to the Spanish /ʝ/. Our goal is to examine influence from English (i.e., the majority language) in heritage speakers’ production of the Spanish /ʝ/ by testing the effect of orthography (i.e., whether stronger influence is found in ⟨y⟩ than in ⟨ll⟩). Heritage speech data were collected using a read-aloud task in which the stimuli varied in orthography, preceding vowel height, and stress condition. Results showed that heritage speakers predominantly produced the Spanish /ʝ/ as an English-like approximant [j], which was preferred even more when /ʝ/ was written with ⟨y⟩. However, the orthography effect surfaced only when the phonetic contexts did not favor strong constriction, suggesting that orthography-induced majority language influence is conditioned by universal phonetic principles.
The Waqf Estates of Pānḍūa: Historical Analysis (from Fifteenth to Twentieth Centuries)
Authors: Zaweed Salim 
Published: October 2021

In its first section, the article examines the creation of two major Sufi institutions, the khanqāhs of Shaikh Jalāluddīn Tabrīzī (d. 1225) known as Badi dargā h and Shaikh Nūr Quṭb Ālam (d. 1410) as Chhotī dargā h. Further, for the smooth functioning and maintenance, the rulers of Ilyas Shahi dynasty and other independent rulers of Bengal endowed rent-free lands to the respective khanqāhs presently known as Bāis Hazārī and Shash Hazārī waqf estates. The present study also attempts to look into a more comprehensive and detailed analysis of the sanads concerning with these grants were confirmed and continued by the Mughal emperors, Nawab Nazims of Bengal and British officials that testify to the importance of the place during the pre-colonial times. The extensive property enjoyed by the mutawallis of these dargā hs continued till date. The focus of the article in its second section, on the historical changes of these waqf estates basing on official records from these institutions, court proceedings of the litigations, historical works by the mutawallis and other connected histories. This examination is followed by a discussion of the gradual decline of these institutions and subsequent patronage for the education and other measures of welfare for the society.
The Parkinson’s Disease-Cognitive Rating Scale: Greek Normative Data, Clinical Utility and Cultural Considerations
Authors: Aretouli Eleni , Chondrogiorgi Maria , Dede Olga , Koutsonida Myrto , Lafi Chrysi , Konstantinopoulou Eleni , Kulisevsky Jaime , Kosmidis Mary H. , Konitsiotis Spiridon 
Published: October 2021

Background: The Parkinson’s Disease-Cognitive Rating Scale (PD-CRS) is a comprehensive screening procedure for the evaluation of cognitive impairment in patients with Parkinson’s disease (PD). Objectives: In the present study we adjusted the PD-CRS for the Greek population, developed normative data and examined its clinical utility for the assessment of cognitive functioning in Greek PD patients. In addition, the correlation of clinical characteristics with cognitive performance in PD patients was examined. Methods: Three hundred four community-dwelling healthy adults and 59 patients with PD, completed the adapted PD-CRS. Results: Healthy adults outperformed the PD patients on the total, the cortical and subcortical scores of the PD-CRS. Normative data indicated effects of both education and age on the PD-CRS. The optimal total PD-CRS cutoff score for the identification of cognitive impairment in a heterogeneous sample of PD patients, with regard to the severity of cognitive difficulties, was 79, yielding a modest sensitivity and specificity. Clinical characteristics of the patients (i.e., disease duration and functional disease burden) were related to poor performance on the PD-CRS. Conclusions: The Greek version of the PD-CRS is a useful instrument for the assessment of cognition in PD. Future prospective studies should examine its clinical utility to identify PD-cognitive subtypes (i.e., PD patients with mild cognitive impairment), to monitor cognitive changes, as well as its predictive accuracy for subsequent dementia.
Long-term Morphological Changes of the Velum and the Nasopharynx in Patients With Cleft Palate
Authors: Harada Takeshi , Yamanishi Tadashi , Kurimoto Takayuki , Uematsu Setsuko , Yamamoto Yuri , Inoue Naoko , Nishio Juntaro 
Published: October 2021

Objective To investigate long-term morphological changes in the soft palate length and nasopharynx in patients with cleft palate. We hypothesized that there would be differences in the morphological development of the soft palate and nasopharynx between patients with and without cleft palate and that these developmental changes would negatively affect the soft palate length to pharyngeal depth ratio involved in velopharyngeal closure for patients with cleft palate. Design Retrospective, case-control study. Setting Institutional practice. Patients Ninety-two patients (Group F) with unilateral cleft lip, alveolus, and palate and 67 patients (Group CLA) with unilateral cleft lip and alveolus not requiring palatoplasty were included. Main Outcome Measures The soft palate length, nasopharyngeal size, and soft palate length to pharyngeal depth ratio were measured via lateral cephalograms obtained at three different periods. Results Group F showed a shorter soft palate length and smaller nasopharyngeal size than Group CLA at all periods. Both these parameters increased with age, but the increase in amount was significantly less in Group F compared with that in Group CLA. The soft palate length to pharyngeal depth ratio in Group F decreased with age. Conclusions In patients with cleft palate, the soft palate length to pharyngeal depth ratio, which is involved in velopharyngeal closure, can change with age. Less soft palate length growth and unfavorable relationship between the soft palate and nasopharynx may be masked in early childhood but can manifest later on with age.
Sustained erythrocytosis due to the use of Lenvatinib
Authors: Kaur Jaspreet , Tuler Shahaf , Dasanu Constantin A 
Published: October 2021

Introduction Tyrosine kinase inhibitors have become the mainstay of treatment for many malignancies, but their use can be accompanied by unusual and often puzzling side effects. Case report We describe herein a 64-year-old patient who developed a robust and sustained erythrocytosis shortly after starting treatment with lenvatinib. Our patient also experienced elevated blood pressure, mucositis, and hand-foot syndrome that are not uncommonly seen with this agent. The clinico-laboratory work-up suggested that lenvatinib was the likely culprit in this case. Management & Outcome Lenvatinib had to be discontinued due to suboptimal tolerance and a short-lived response. With the discontinuation of lenvatinib, hemoglobin trended downwards and subsequently resolved. A score of 6 on the Naranjo nomogram supported a probable causality relationship between lenvatinib and the observed erythrocytosis. Discussion Erythrocytosis has previously been described with sunitinub, sorafenib and pazopanib. The exact mechanism of this phenomenon is not known. It might increase the risk of venous and arterial thromboses in cancer patients that are already in a hypercoagulable state due to cancer itself. In addition, laboratory work-up for polycythemia may prove extensive and costly. Therefore, clinicians need to be aware of this important side effect of tyrosine kinase inhibitors.
Hospital Outdoor Spaces: User Experience and Implications for Design
Authors: Tseung Victrine , Verweel Lee , Harvey Martha , Pauley Tim , Walker Jan 
Published: October 2021

Objectives: This article aims to describe users’ perspectives about the impact of hospital outdoor spaces on the patient experience in a postacute setting. Background: Hospital outdoor space is an important element in healthcare facility design. There is growing evidence that access to green space within hospital outdoor spaces facilitates healing. However, limited studies have explored the users’ perspective regarding how hospital outdoor spaces impact the patient experience. Methods: As part of a hospital preoccupancy evaluation, users (patients, family, and staff) were invited to participate in a semi-structured interview to describe their experiences in the hospital’s outdoor spaces. Data were analyzed using inductive thematic analysis. Results: Seventy-four individuals participated in this study: 24 inpatients, 15 outpatients, 11 family, 23 staff, and one volunteer. Three themes were identified: (1) outdoor space benefits healing by helping patients focus on life beyond their illness, (2) design of healthcare spaces facilitates patients’ access to outdoor space to benefit healing, and (3) programming in the outdoor space promotes healing and recovery. Conclusions: This study describes the users’ perspective regarding the value of outdoor spaces and the design elements that influence the patient experience.
Evaluating the Impact of a Multisensory Environment on Target Behaviors of Children With Autism Spectrum Disorder
Authors: Kim Min-Kyoung , Park Nam-Kyu 
Published: October 2021

Background: Worldwide, children are increasingly being diagnosed with autism spectrum disorder (ASD). The case of South Korea is not exceptional. One of the core symptoms of children with ASD is sensory reactivity issues, such as an unusual interest in the sensory aspects of the environment. One promising development in sensory enrichment for individuals with ASD is a multisensory environment (MSE). Objectives: This study investigated the influence of MSE on the target behaviors of children with ASD with different sensory characteristics in the case of South Korea. Methods: A multiple treatment design {A-B-C-D (B + C) phases} was implemented to observe the six target behaviors of three children with ASD. The sensory environmental intervention focusing on visual and auditory stimuli was manipulated as a stimulating MSE or a relaxing MSE depending on the sensory profile of each participant. The analysis was undertaken using visual inspection with data patterns and graph slopes, which is a customary method of analyzing the single-subject design data. In addition, the means and standard deviations of the two target behaviors of each participant were analyzed together. Results: The findings reveal that MSE interventions positively affected the target behaviors of children with ASD with diverse sensory characteristics. The stimulating MSE created by the integration of visual and auditory stimuli was the most effective intervention for the participants with hypo-visual and hypo-auditory sensitivities in this study. Conclusions: The MSE could be meaningful as a nonpharmaceutical therapy that could influence the daily behaviors of children with ASD.
An Audit of Opportunistic Lung Cancer Screening in a Canadian Province
Authors: Linehan Victoria , Harris Scott , Bhatia Rick 
Published: October 2021

Objectives: Lung cancer is a leading cause of cancer-related death in Canada. Early detection can improve outcomes and despite recommendations from the Canadian Task Force on Preventive Health Care to screen patients who are 55 to 74 years old and have a 30+ pack-year history, formal screening programs are rare in Canada. Our goal was to determine if screening is being performed in a representative Canadian population, if recommendations are being followed, and how screening impacts lung cancer stage at diagnosis and prognosis. Methods: A retrospective chart review was performed to identify patients either screened for lung cancer or imaged due to lung cancer symptoms in Eastern Newfoundland between 2015 and 2018. Age, smoking history, screening modality, diagnosis, cancer stage, and mortality were recorded. Results: Under 6.0% of the eligible population were screened for lung cancer with only 28.13% meeting age and smoking criteria and being screened appropriately with low-dose CT. However, 70% of patients that had lung cancers found by screening met age and smoking screening criteria. While lung cancer detection rates were similar, screening detected cancer in patients at an earlier stage (50% Stage 1) compared to patients who were not screened (20% Stage 1). Patients who were screened had an improved prognosis. Conclusions: Physicians are opportunistically screening for lung cancer, but not consistently following screening guidelines. As screening is sensitive, leads to earlier stage diagnosis, and has a mortality benefit, implementation of an organized screening program could increase quality assurance and prevent many lung-cancer related deaths.
Combined Effects of Auditing and Discretionary Accruals on the Cost of Debt: Evidence From Spanish SMEs
Authors: Gandía Juan L. , Huguet David 
Published: October 2021

Previous literature shows mixed evidence on the effect of discretionary accruals and auditing on the cost of debt. We hypothesize that, in the SMEs setting, auditing can act as a substitute for accruals quality, and thus audits may mitigate the effect of discretionary accruals on the cost of debt. Using a sample of Spanish SMEs, we find that auditing is negatively related with the cost of debt, while higher discretionary accruals are related with a lower cost of debt. Nonetheless, this effect is lower than that one observed for audits. When considering the combined effect of both variables, the effect of discretionary accruals is replaced by that of auditing. These results suggest that, among SMEs, discretionary accruals do not have a relevant effect on the cost of debt when companies are audited, supporting the hypothesis that there exists a substitution effect between discretionary accruals and auditing. JEL Classification: M42; G32