bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of metabolic changes after neoadjuvant endocrine and chemotherapy in ER-positive, HER2-negative breast cancer
Authors: Ryu Ho Hyun , Ahn Sei Hyun , Kim Seon Ok , Kim Jeong Eun , Kim Ji sun , Ahn Jin-Hee , Jung Kyung Hae , Kim Sung-Bae , Ko Beom Seok , Lee Jong Won , Son Byung Ho , Shin Hee Jung , Kim Hak Hee , Gong Gyung yub , Kim Hee Jeong 
Published: May 2021

AbstractSurvival of breast cancer patients has improved, and treatment-related changes regarding metabolic profile deterioration after neoadjuvant systemic treatment (NST) become important issues in cancer survivors. We sought to compare metabolic profile changes and the neutrophil-to-lymphocyte ratio (NLR) between patients undergoing neoadjuvant chemotherapy (NCT) and neoadjuvant endocrine therapy (NET) 3 years after the treatment. In a prospective, randomized, phase III trial which compared 24 weeks of NCT with adriamycin and cyclophosphamide followed by docetaxel and NET with goserelin and tamoxifen (NEST), 123 patients in the Asan Medical Center were retrospectively reviewed to evaluate metabolic changes, such as body mass index (BMI), blood pressure (BP), total cholesterol (TC), fasting glucose, and the NLR. The mean age of patients was 42 years. The changes in BMI, serum glucose, and TC during NST and after 3 years were significantly different between NCT and NET. The proportion of overweight + obese group and the mean BMI were significantly increased during NCT (26.6% to 37.5%, 22.84 kg/m2 to 23.87 kg/m2, p < 0.05), and these attributes found to have normalized at the 3-year follow-up. In the NET group, BMI changes were not observed (p > 0.05, all). There were no differences in changes over time among in the Hypertension group during NCT and NET (p = 0.96). The mean value of serum TC and fasting glucose significantly increased (< 0.05, both) during NCT and decreased 3 years after NCT (p < 0.05); however, no significant changes were observed in the NET group. The NLR was increased from 1.83 to 3.18 after NCT (p < 0.05) and decreased from 1.98 to 1.43 (p < 0.05) after NET. Compared with minimal metabolic effect of NET, NCT worsens metabolic profiles, which were recovered over 3 years. The NLR was increased after NCT but decreased after NET.
Effect of intraoperative fluid volume on postoperative ileus after robot-assisted radical cystectomy
Authors: Shim Ji Sung , Noh Tae Il , Ku Ja Hyeon , Lee Sangchul , Kwon Tae Gyun , Kim Tae-Hwan , Jeon Seung Hyun , Lee Sang Hyup , Nam Jong Kil , Kim Wan Seok , Jeong Byong Chang , Lee Ji Youl , Hong Sung Hoo , Rha Koon Ho , Han Woong Kyu , Ham Won Sik , Lee Young Goo , Lee Yong Seong , Park Sung Yul , Yoon Young Eun , Kang Sung Gu , Oh Jong Jin , Kang Seok Ho ,   Korean Robot Assisted Radical Cystectomy (KORARC) Study Group, Shim Ji Sung , Noh Tae Il , Ku Ja Hyeon , Lee Sangchul , Kwon Tae Gyun , Kim Tae-Hwan , Jeon Seung Hyun , Lee Sang Hyup , Nam Jong Kil , Kim Wan Seok , Jeong Byong Chang , Lee Ji Youl , Hong Sung Hoo , Rha Koon Ho , Han Woong Kyu , Ham Won Sik , Lee Young Goo , Lee Yong Seong , Park Sung Yul , Yoon Young Eun , Kang Sung Gu , Oh Jong Jin , Kang Seok Ho 
Published: May 2021

AbstractThis study aimed to investigate the effect of intraoperative fluid volume on the postoperative ileus (POI) recovery period. A retrospective review of the Korean robot-assisted radical cystectomy database identified 718 patients who underwent robot-assisted radical cystectomy (RARC). Regression analyses were performed to identify the associations between the amount of intraoperative fluid administration (crystalloid/colloid/total), POI period (time to flatus/bowel movements), and length of hospital stay (LOS) after adjusting for covariates. In addition, we analyzed the risk factors for gastrointestinal complications and prolonged POI using a logistic regression model. An increasing volume of the administered crystalloid/total fluid was associated with prolonged POI (crystalloid R2 = 0.0725 and P < 0.0001; total amount R2 = 0.0812 and P < 0.0001), and the total fluid volume was positively associated with the LOS (R2 = 0.099 and P < 0.0001). The crystalloid amount was a risk factor for prolonged POI (P < 0.001; odds ratio, 1.361; 95% confidence interval, 1.133–1.641; P < 0.001). In the context of RARC, increased intravenous fluids are associated with prolonged POI and longer LOS.
The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study
Authors: Yao Wei-Cheng , Chen Hsuan-Ju , Leong Kam-Hang , Chang Kai-Lan , Wang Yu-Ting Tina , Wu Li-Chin , Tung Po-Ya , Kuo Chien-Feng , Lin Che-Chen , Tsai Shin-Yi 
Published: May 2021

AbstractSince iron is essential for neurotransmitter synthesis, decreased iron stores might lead to reduced production of biogenic amines which phenomenon was shown in Fibromyalgia (FM) patients. The aims are to investigate the association of iron deficiency anemia (IDA) and FM and to find the effects of different interventions. We conducted a study using the Taiwan National Health Insurance Research Database. The IDA cohort consisted of 13,381 patients with newly diagnosed IDA between 2000 and 2008. Each patient with IDA was frequency-matched with one people without IDA, by sex, age and index year. The Cox proportional hazards regression analysis was conducted to estimate the association between IDA and FM risk. The event was the occurrence of FM. The overall incidence density rate of FM in the IDA cohort was higher than in the non-IDA cohort with a multivariable Cox proportional hazards model measured adjusted hazard ratio [HR], 1.19; 95% confidence interval [CI], 1.13–1.25). When using non-IDA group as reference, we compared with different therapies for IDA. The adjusted HRs of FM were 1.38 (95% CI = 1.30–1.47), 1.10 (95% CI = 1.03–1.16), 1.18 (95% CI = 0.98–1.43) and 0.73 (95% CI = 0.58–0.90) for IDA patient without therapy, iron supplement alone, blood transfusion alone and both iron supplement and blood transfusion respectively. Our results suggest IDA is associated with an increased risk of FM. All patients should have iron supplementation both to correct anemia and replenish body stores.
A deep learning model for detection of cervical spinal cord compression in MRI scans
Authors: Merali Zamir , Wang Justin Z. , Badhiwala Jetan H. , Witiw Christopher D. , Wilson Jefferson R. , Fehlings Michael G. 
Published: May 2021

AbstractMagnetic Resonance Imaging (MRI) evidence of spinal cord compression plays a central role in the diagnosis of degenerative cervical myelopathy (DCM). There is growing recognition that deep learning models may assist in addressing the increasing volume of medical imaging data and provide initial interpretation of images gathered in a primary-care setting. We aimed to develop and validate a deep learning model for detection of cervical spinal cord compression in MRI scans. Patients undergoing surgery for DCM as a part of the AO Spine CSM-NA or CSM-I prospective cohort studies were included in our study. Patients were divided into a training/validation or holdout dataset. Images were labelled by two specialist physicians. We trained a deep convolutional neural network using images from the training/validation dataset and assessed model performance on the holdout dataset. The training/validation cohort included 201 patients with 6588 images and the holdout dataset included 88 patients with 2991 images. On the holdout dataset the deep learning model achieved an overall AUC of 0.94, sensitivity of 0.88, specificity of 0.89, and f1-score of 0.82. This model could improve the efficiency and objectivity of the interpretation of cervical spine MRI scans.
Bouncing behavior of sub-four minute milers
Authors: Burns Geoffrey T. , Gonzalez Richard , Zendler Jessica M. , Zernicke Ronald F. 
Published: May 2021

AbstractElite middle distance runners present as a unique population in which to explore biomechanical phenomena in relation to running speed, as their training and racing spans a broad spectrum of paces. However, there have been no comprehensive investigations of running mechanics across speeds within this population. Here, we used the spring-mass model of running to explore global mechanical behavior across speeds in these runners. Ten elite-level 1500 m and mile runners (mean 1500 m best: 3:37.3 ± 3.6 s; mile: 3:54.6 ± 3.9 s) and ten highly trained 1500 m and mile runners (mean 1500 m best: 4:07.6 ± 3.7 s; mile: 4:27.4 ± 4.1 s) ran on a treadmill at 10 speeds where temporal measures were recorded. Spatiotemporal and spring-mass characteristics and their corresponding variation were calculated within and across speeds. All spatiotemporal measures changed with speed in both groups, but the changes were less substantial in the elites. The elite runners ran with greater approximated vertical forces (+ 0.16 BW) and steeper impact angles (+ 3.1°) across speeds. Moreover, the elites ran with greater leg and vertical stiffnesses (+ 2.1 kN/m and + 3.6 kN/m) across speeds. Neither group changed leg stiffness with increasing speeds, but both groups increased vertical stiffness (1.6 kN/m per km/h), and the elite runners more so (further + 0.4 kN/m per km/h). The elite runners also demonstrated lower variability in their spatiotemporal behavior across speeds. Together, these findings suggested that elite middle distance runners may have distinct global mechanical patterns across running speeds, where they behave as stiffer, less variable spring-mass systems compared to highly trained, but sub-elite counterparts.
Burden of critically ill patients with influenza in a French catchment population
Authors: Hernu Romain , Simon Marie , Baudry Thomas , Casalegno Jean-Sébastien , Lina Bruno , Cour Martin , Argaud Laurent ,   the “Flu in Lyon ICUs” Study Group, Aubrun Frederic , Guérin Claude , Allaouchiche Bernard , Robert Dominique , Bohé Julien , Puidupin Marc , Manchon Jacques , Liron Lionel 
Published: May 2021

AbstractDespite the particular focus given to influenza since the 2009 influenza A(H1N1) pandemic, true burden of influenza-associated critical illness remains poorly known. The aim of this study was to identify factors influencing influenza burden imposed on intensive care units (ICUs) in a catchment population during recent influenza seasons. From 2008 to 2013, all adult patients admitted with a laboratory-confirmed influenza infection to one of the ICUs in the catchment area were prospectively included. A total of 201 patients (mean age: 63 ± 16, sex-ratio: 1.1) were included. The influenza-related ICU-bed occupancy rate averaged 4.3% over the five influenza seasons, with the highest mean occupancy rate (16.9%) observed during the 2012 winter. In-hospital mortality for the whole cohort was 26%. Influenza A(H1N1)pdm infections (pdm in the mentioned nomenclature refers to Pandemic Disease Mexico 2009), encountered in 51% of cases, were significantly associated with neither longer length of stay nor higher mortality (ICU and hospital) when compared to infections with other virus subtypes. SOFA score (OR, 1.12; 95% CI, 1.04–1.29) was the only independent factor significantly associated with a prolonged hospitalization. These results highlight both the frequency and the severity of influenza-associated critical illness, leading to a sustained activity in ICUs. Severity of the disease, but not A(H1N1)pdm virus, appears to be a major determinant of ICU burden related to influenza.
Mechanism of the improvement of the energy of host–guest explosives by incorporation of small guest molecules: HNO3 and H2O2 promoted C–N bond cleavage of the ring of ICM-102
Authors: Xiao Yiwen , Chen Lang , Yang Kun , Geng Deshen , Lu Jianying , Wu Junying 
Published: May 2021

AbstractHost–guest materials exhibit great potential applications as an insensitive high-energy–density explosive and low characteristic signal solid propellant. To investigate the mechanism of the improvement of the energy of host–guest explosives by guest molecules, ReaxFF-lg reactive molecular dynamics simulations were performed to calculate the thermal decomposition reactions of the host–guest explosives systems ICM-102/HNO3, ICM-102/H2O2, and pure ICM-102 under different constant high temperatures and different heating rates. Incorporation of guest molecules significantly increased the energy level of the host–guest system. However, the initial reaction path of the ICM-102 molecule was not changed by the guest molecules. The guest molecules did not initially participate in the host molecule reaction. After a period of time, the H2O2 and HNO3 guest molecules promoted cleavage of the C–N bond of the ICM-102 ring. Stronger oxidation and higher oxygen content resulted in the guest molecules more obviously accelerating destruction of the ICM-102 ring structure. The guest molecules accelerated the initial endothermic reaction of ICM-102, but they played a more important role in the intermediate exothermic reaction stage: incorporation of guest molecules (HNO3 and H2O2) greatly improved the heat release and exothermic reaction rate. Although the energies of the host–guest systems were clearly improved by incorporation of guest molecules, the guest molecules had little effect on the thermal stabilities of the systems.
Differentiation of two swim bladdered fish species using next generation wideband hydroacoustics
Authors: Gugele Sarah M. , Widmer Marcus , Baer Jan , DeWeber J. Tyrell , Balk Helge , Brinker Alexander 
Published: May 2021

AbstractMonitoring fish populations in large, deep water bodies by conventional capture methodologies requires intensive fishing effort and often causes mass mortality of fish. Thus, it can be difficult to collect sufficient data using capture methods for understanding fine scale community dynamics associated with issues such as climate change or species invasion. Hydroacoustic monitoring is an alternative, less invasive technology that can collect higher resolution data over large temporal and spatial scales. Monitoring multiple species with hydroacoustics, however, usually requires conventional sampling to provide species level information. The ability to identify the species identity of similar-sized individuals using only hydroacoustic data would greatly expand monitoring capabilities and further reduce the need for conventional sampling. In this study, wideband hydroacoustic technology was used in a mesocosm experiment to differentiate between free swimming, similar-sized individuals of two swim-bladdered species: whitefish (Coregonus wartmanni) and stickleback (Gasterosteus aculeatus). Individual targets were identified in echograms and variation in wideband acoustic responses among individuals, across different orientations, and between species was quantified and visually examined. Random forest classification was then used to classify individual targets of known species identity, and had an accuracy of 73.4% for the testing dataset. The results show that species can be identified with reasonable accuracy using wideband hydroacoustics. It is expected that further mesocosm and field studies will help determine capabilities and limitations for classifying additional species and monitoring fish communities. Hydroacoustic species differentiation may offer novel possibilities for fisheries managers and scientists, marking the next crucial step in non-invasive fish monitoring.
De novo transcriptome assembly and comparative transcriptomic analysis provide molecular insights into low temperature stress response of Canarium album
Authors: Lai Ruilian , Feng Xin , Chen Jin , Zhang Yongyan , Wei Xiaoxia , Chen Yiting , Cheng Chunzhen , Wu Rujian 
Published: May 2021

AbstractA de novo transcriptome analysis was performed in C. album, a temperature sensitive fruit tree in China, after treatment with varied temperatures. A total number of 168,385 transcripts were assembled, comprising of 109,439 unigenes, of which 70,530 were successfully annotated. Compared with control check group (CK), which was treated under 25 °C, the chilling stress (4 °C) treated group (CT), showed about 2810 up-regulated and 2567 down-regulated genes. Whereas, group treated under freezing (− 3 °C) stress (FT) showed an up-regulation and a down-regulation of 1748 and 1459 genes, respectively. GO classification analysis revealed that DEGs related to metabolic processes, single-organism metabolic process, and catalytic activity are significantly enriched in both CT and FT conditions. KEGG pathway enrichment analysis for both CT and FT treatments showed an enrichment of genes encoding or related to glycine/serine and threonine metabolism, alpha-linolenic acid metabolism, carotenoid biosynthesis, photosynthesis-antenna proteins, and circadian rhythm. However, genes related to photosynthesis, carbon fixation in photosynthetic organisms, glutathione metabolism, pyruvate metabolism, nicotinate and nicotinamide metabolism were specifically enriched in CT condition. Nevertheless, FT treatment induced genes related to plant-pathogen interaction, linoleic acid metabolism, plant hormone signal transduction and pentose phosphate pathway. Many of the genes involved in plant hormone signal transduction showed significantly different expression in both FT and CT conditions. However, the change was more evident in FT. Here we present the first of the reports for a de novo transcriptomic analysis in C. album, suggesting that the plant shows differential responses in chilling and freezing temperatures, where the hormone signaling and transduction contribute greatly to FT responses. Our study thus paves way for future research regarding functions of these potentially identified genes.
Biosynthesis of silver nanoparticles for the fabrication of non cytotoxic and antibacterial metallic polymer based nanocomposite system
Authors: Raza Sadaf , Ansari Asma , Siddiqui Nadir Naveed , Ibrahim Fariha , Abro Muhammad Ishaque , Aman Afsheen 
Published: May 2021

AbstractNanomaterials have significantly contributed in the field of nanomedicine as this subject matter has combined the usefulness of natural macromolecules with organic and inorganic nanomaterials. In this respect, various types of nanocomposites are increasingly being explored in order to discover an effective approach in controlling high morbidity and mortality rate that had triggered by the evolution and emergence of multidrug resistant microorganisms. Current research is focused towards the production of biogenic silver nanoparticles for the fabrication of antimicrobial metallic-polymer-based non-cytotoxic nanocomposite system. An ecofriendly approach was adapted for the production of silver nanoparticles using fungal biomass (Aspergillus fumigatus KIBGE-IB33). The biologically synthesized nanoparticles were further layered with a biodegradable macromolecule (chitosan) to improve and augment the properties of the developed nanocomposite system. Both nanostructures were characterized using different spectrographic analyses including UV–visible and scanning electron microscopy, energy dispersive X-ray analysis, dynamic light scattering, and Fourier transform infrared spectroscopic technique. The biologically mediated approach adapted in this study resulted in the formation of highly dispersed silver nanoparticles that exhibited an average nano size and zeta potential value of 05 nm (77.0%) and − 22.1 mV, respectively with a polydispersity index of 0.4. Correspondingly, fabricated silver–chitosan nanocomposites revealed a size of 941 nm with a zeta potential and polydispersity index of + 63.2 mV and 0.57, respectively. The successful capping of chitosan on silver nanoparticles prevented the agglomeration of nanomaterial and also facilitated the stabilization of the nano system. Both nanoscopic entities exhibited antimicrobial potential against some pathogenic bacterial species but did not displayed any antifungal activity. The lowest minimal inhibitory concentration of nanocomposite system (1.56 µg ml−1) was noticed against Enterococcus faecalis ATCC 29212. Fractional inhibitory concentration index of the developed nanocomposite system confirmed its improved synergistic behavior against various bacterial species with no cytotoxic effect on NIH/3T3 cell lines. Both nanostructures, developed in the present study, could be utilized in the form of nanomedicines or nanocarrier system after some quantifiable trials as both of them are nonhazardous and have substantial antibacterial properties.
Inhibitory influence of cationic Gemini surfactant on the dissolution rate of N80 carbon steel in 15% HCl solution
Authors: Deyab M. A. , Mohsen Q. 
Published: May 2021

AbstractStrong acids are commonly used in petroleum wells to remove scale layers from the surface of N80 C-steel pipe. The corrosive effects of these acids, on the other hand, pose a significant risk to C-steel pipes. For the first time, we discovered the anti-corrosion properties of cationic Gemini surfactant, 1,2-bis(dodecyldimethylammonio) ethane dibromide (DMAEB), for N80 C-steel pipe in acid washing solution (15.0% HCl). The DMAEB, in particular, can reduce the corrosion rate of N80 C-steel by approximately 97%. DMAEB molecules work as a mixed-type corrosion inhibitor, according to electrochemical results. The DMAEB demonstrated a high inhibition effect at high temperatures, as well as high activation energy against the corrosion process. DMAEB's significant performance is primarily due to physical adsorption on the N80 C-steel surface, as confirmed by adsorption isotherms, SEM, EDX, FT-IR, and theoretical studies. Our findings shed new light on the use of Gemini surfactants as corrosion inhibitors in petroleum wells.
Analysis of the occurrence of hemophagocytic lymphohistiocytosis (HLH) features in patients with sepsis: a prospective study
Authors: Bursa Dominik , Bednarska Agnieszka , Pihowicz Andrzej , Paciorek Marcin , Horban Andrzej 
Published: May 2021

AbstractHLH syndrome may mimic sepsis but requires entirely different treatment. The aim of the study was to assess the occurrence of HLH features in patients with sepsis and the influence these exert on the patients’ prognosis. The prospective study included 108 patients with suspected sepsis who were routinely evaluated according to HLH criteria. They were divided into group I (SOFA = 2, n = 57) and group II (SOFA ≥ 3, n = 51). Four patients were excluded from analysis: 1 with real HLH, 2 with Still’s disease and 1 with lymphoma. The median (IQR) concentration of ferritin was 613.4 (850.3) ng/mL, however 6 patients revealed a remarkedly high ferritin concentration > 3000 ng/mL, including 2 with ferritin > 10,000 ng/mL. In total, 21 patients met ≥ 4/8 HLH criteria and were found to have sepsis with HLH-like syndrome (SHLS). Out of these, 19 responded to antimicrobials, 2 died due to infection. The sepsis patients presented with the following HLH criteria: fever (95.2%), hyperferritinemia (57.3%), splenomegaly (43.4%), reduced NK cell activity (35.2%), high sCD25 activity (27.4%) and rarely: hypertriglyceridemia (14.4%), duopenia (5.8%), hypofibrinogenemia (1.9%). Although group II patients had higher odds for SHLS presentation (OR 3.26, p = 0.026) and for death (OR 14.3, p = 0.013), SHLS occurrence had no impact on the risk of death (OR 0.77, p = 0.75). Sepsis patients can present with SHLS exclusively due to severe infection. Duopenia, hypertriglyceridemia, hypofibrinogenemia and high level of sCD25 are unusual in sepsis and might indicate real HLH syndrome. Hyperferritinemia, even as high as in real HLH syndrome, can occur in sepsis patients.
Fe3O4@PANI: a magnetic polyaniline nanomaterial for highly efficient and handy enrichment of intactN-glycopeptides
Authors: Lai Zhizhen , Zhang Mo , Zhou Jinyu , Chen Tianjing , Li Dan , Shen Xuejing , Liu Jia , Zhou Jiang , Li Zhili 
Published: May 2021

Fe3O4@PANI can be utilized in efficiently enriching intact N-glycopeptides from complex biological samples based on hydrogen bond and electrostatic adsorption between glycopeptides and this bifunctional nanomaterial.