bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faktor yang Memengaruhi Kejadian Pernikahan Usia Dini pada Remaja Putri di Kecamatan Lembah Melintang
Authors: Narti Samsi 
Published: February 2021

Pernikahan dini merupakan sebuah pernikahan yang dilakukan oleh seseorang yang masih dalam usia 20 tahun. Dampak pernikahan dini baik pada ibu hamil dan melahirkan dapat terjadi kematian maternal 2-5 kali lebih tinggi dari pada usia 20-29 tahun sedangkan dampak sosialnya berpotensi pada perceraian. Risiko yang akan terjadi seperti anemia, BBLR, aborsi dan dapat berisiko 2 kali lipat untuk mendapatkan kanker servik. Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang mempengaruhi kejadian pernikahan dini di Kecamatan Lembah Melintang. Jenis penelitian ini bersifat survey analitik dengan desain penelitian cross sectional dengan teknik total populasi dan sampel berjumlah 96 remaja putri. Metode analisis data yang digunakan meliputi analisis univariat dan analisis bivariat dengan uji chi-square untuk mengetahui hubungan signifikan antara pengetahuan, sikap, dan budaya dengan kejadian pernikahan dini pada remaja putri. Hasil penelitian ini menunjukkan ada hubungan pengetahuan dengan kejadian pernikahan dini (0,000 0,05), ada hubungan sikap dengan kejadian pernikahan dini (0,000 0,05), dan ada hubungan budaya dengan kejadian pernikahan dini (0,000 0,05). Saran dari peneliti adalah diharapkan kepada petugas kesehatan khususnya bidan dan bagian kependudukan agar mengaktifkan program Pusat Informasi dan Konseling Remaja (PIKR) dan Bina Keluarga Remaja (BKR). Kerjasama lintas program dan lintas sektoral seperti BKKBN, dinas kesehatan, tokoh agama, tokoh masyarakat, kepala sekolah dan Kepala KUA juga dibutuhkan.
Fluid Inclusions and H–O–C–S–Pb Isotopic Systematics of the Jinba Gold Deposit, NW China: Implications for Ore Genesis
Authors: Li Shun-Da , Chen Chuan , Gao Ling-Ling , Xia Fang , Zhang Xue-Bing , Wang Ke-Yong 
Published: February 2021

The Jinba gold deposit is located in the Maerkakuli Shear Zone of the south Altay Orogenic Belt, NW China. Mineralization types are classified as altered rock–and quartz vein–type. Orebodies occur as veins or lenses controlled by NW–trending faults, and are hosted in phyllite (Early–Middle Devonian Ashele Formation) and plagiogranite (Early Devonian Habahe Pluton). Three paragenetic stages were identified: early quartz–pyrite–gold (Stage 1), middle quartz–chalcopyrite (Stage 2), and late calcite–quartz–galena–sphalerite (Stage 3). Fluid inclusions within the deposit are liquid–rich aqueous (LV–type), vapor–rich aqueous (VL–type), carbonic–aqueous (LC–type), and purely carbonic (C–type) FIs. Homogenization temperatures for stages 1–3 FIs were 373–406 °C, 315–345 °C, and 237–265 °C, respectively. Fluid salinities for stages 1–3 were 2.1–13.6 wt%, 3.2–6.1 wt% and 3.9–6.0 wt% NaCl equivalent, respectively. The ore–forming fluids evolved from a CO2–NaCl–H2O ± CH4 to a NaCl–H2O system from stage 1–3. Oxygen, hydrogen, and carbon isotopic data (δ18Ofluid = 1.7‰–8.1‰, δDfluid = –104.1‰ to –91.7‰, δ13Cfluid = –0.4‰–6.3‰) indicate that ore–forming fluids were metamorphic hydrothermal origin with the addition of a late meteoric fluid. Sulfur and lead isotope data for pyrite (δ34Spy = 3.3‰–5.3‰, 206Pb/204Pb = 17.912.3–18.495, 207Pb/204Pb = 15.564–15.590, 208Pb/204Pb = 37.813–38.422) show that the ore–forming materials were mainly derived from diorite and the Ashele Formation. Mineralization, FIs, and isotope studies demonstrate that the Jinba deposit is an orogenic gold deposit.
Metastatic Orbital Tumor From Breast Ductal Carcinoma With Neuroendocrine Differentiation Initially Presenting as Ocular Symptoms: A Case Report and Literature Review
Authors: Togashi Keita , Nishitsuka Koichi , Hayashi Shion , Namba Hiroyuki , Goto Sakiko , Takeda Yusuke , Suzuki Shuhei , Kato Tomoya , Yamada Yuki , Konno Eriko , Yoshioka Takashi , Yamakawa Mitsunori , Sonoda Yukihiko , Suzuki Tamio , Yamashita Hidetoshi 
Published: February 2021

BackgroundOrbital metastases from cancers of various organs can arise via the hematogenous route, and many originate from breast, prostate, and lung cancers. Such metastatic orbital tumors may be diagnosed before the primary tumor. We have encountered a case of breast ductal carcinoma with neuroendocrine differentiation that metastasized to the orbit and responded to chemotherapy, with improvement in visual function.Case PresentationA woman in her fifties visited our ophthalmology department with a chief complaint of foreign body sensation and exophthalmos in her right eye. An elastic soft mass was palpated from the lateral orbit to the temporal region. A systemic examination revealed breast cancer and a metastatic orbital tumor. Excisional biopsy of the breast revealed a diagnosis of invasive ductal carcinoma with neuroendocrine differentiation, and immunohistochemical examination was negative for cytokeratin 7, making the case unusual. Chemotherapy was remarkably effective, and the tumor size decreased, resulting in improvement of visual function. Her general condition and quality of life are still good at present. We searched the PubMed English language literature focusing on metastatic orbital tumors from breast cancer in which ocular symptoms had been the initial presenting sign. No previous reports have documented neuroendocrine differentiation or cytokeratin 7 expression in isolated orbital metastases from breast cancer. Although it is not possible to be certain from this case alone, we speculated that some such cases might involve cytokeratin 7-negative invasive breast cancer with neuroendocrine differentiation.ConclusionWe have described our experience of a very rare case of cytokeratin 7 negative breast ductal carcinoma with neuroendocrine differentiation that metastasized to the orbit and formed a solitary giant tumor initially manifesting as ocular symptoms.
Lower Baseline Serum Triglyceride Levels Are Associated With Higher Decrease in Body Mass Index After Laparoscopy Sleeve Gastrectomy Among Obese Patients
Authors: Huang Xiu , Li Guifang , Xu Bei , Zhang Junyi , Wang Xingchun , Cheng Xiaoyun , Jayachandran Muthukumaran , Huang Yueye , Qu Shen 
Published: February 2021

AimsTo investigate the predictive value of baseline serum triglyceride (TG) levels for improvements of metabolism after laparoscopic sleeve gastrectomy (LSG).Methods112 obese patients [body mass index (BMI) ≥ 35 kg/m2] underwent LSG and with complete information of anthropometric and metabolic parameters were divided into normal TG group (group A) and high TG group (group B), while group A had TG levels ≤ 1.7 mmol/L, and group B had TG levels &gt; 1.7 mmol/L. The post-operative changes (Δ) in metabolic parameters between the two groups were compared.ResultsIn the whole cohort, the metabolic parameters were significantly improved at 6 months after LSG. BMI and waist circumference (WC) decreased significantly in the two groups. The ΔBMI among group A and group B were 11.42±3.23 vs 9.13±2.77 kg/m2 (p&lt;0.001), respectively. ΔBMI was positively correlated with ΔWC (r=0.696, p&lt;0.001), Δfasting insulin level (r=0.440, p=0.002), Δfasting serum C peptide level (r=0.453, p=0.002), and Δhomeostasis model assessment insulin resistance index (r=0.418, p=0.004) in group A. Compared with group B, group A had a significantly higher odds ratio (OR) of 2.83 (95% confidence interval [CI]1.25–6.38, p=0.012)and 2.73 (95% CI 1.11–6.72, p=0.029) for ΔBMI and ΔWC after adjustment for age and gender, respectively.ConclusionsObese patients with baseline TG levels under 1.7 mmol/L had greater loss of weight at six months follow-up later LSG. This finding suggests that baseline TG level may have a predictive value for weight loss, at least in the short-term follow-up.
Design and Performance of a Compact Air-Breathing Jet Hybrid-Electric Engine Coupled With Solid Oxide Fuel Cells
Authors: Ji Zhixing , Qin Jiang , Cheng Kunlin , Liu He , Zhang Silong , Dong Peng 
Published: February 2021

A compact air-breathing jet hybrid-electric engine coupled with solid oxide fuel cells (SOFC) is proposed to develop the propulsion system with high power-weight ratios and specific thrust. The heat exchanger for preheating air is integrated with nozzles. Therefore, the exhaust in the nozzle expands during the heat exchange with compressed air. The nozzle inlet temperature is obviously improved. SOFCs can directly utilize the fuel of liquid natural gas after being heated. The performance parameters of the engine are acquired according to the built thermodynamic and mass models. The main conclusions are as follows. 1) The specific thrust of the engine is improved by 20.25% compared with that of the traditional jet engine. As pressure ratios rise, the specific thrust increases up to 1.7 kN/(kg·s−1). Meanwhile, the nozzle inlet temperature decreases. However, the temperature increases for the traditional combustion engine. 2) The power-weight ratio of the engine is superior to that of internal combustion engines and inferior to that of turbine engines when the power density of SOFC would be assumed to be that predicted for 2030. 3) The total pressure recovery coefficients of SOFCs, combustors, and preheaters have an obvious influence on the specific thrust of the engine, and the power-weight ratio of the engine is strongly affected by the power density of SOFCs.
DHCR7 rs12785878 T>C Polymorphism Is Associated With an Increased Risk of Early Onset of Alzheimer's Disease in Chinese Population
Authors: Liu Xixi , Wu Pengfei , Shen Lu , Jiao Bin , Liao Xinxin , Wang Haochen , Peng Jiangnan , Lin Zhangyuan 
Published: February 2021

Background: Vitamin D insufficiency has been considered a risk factor for Alzheimer's disease (AD) in several studies. Recently, four single-nucleotide polymorphisms (SNPs) to be genome-wide significant for 25-hydroxyvitamin D [25(OH)D] were identified to have an association with the risk of AD. These include GC rs2282679 A&gt;C, CYP2R1 rs10741657 T&gt;C, DHCR7 rs12785878 T&gt;C, and CYP24A1 rs6013897 T&gt;A. However, the association between these polymorphisms and AD susceptibility in the Chinese population remains unclear.Methods: A case-control cohort study was conducted in 676 AD patients (mean age at onset was 69.52 ± 10.90 years, male: 39.2%) and 551 healthy controls (mean age was 67.73 ± 6.02 years, male: 44.8%). Genotyping was determined by PCR and SNaPshot sequencing. To determine whether the four SNPs account for risks in AD in Chinese population, multivariate logistic regression models were performed. Stratified analysis was performed based on gender and age of onset of AD, separately. Statistical significance was set at 0.0125 (0.05/4) based on Bonferroni correction.Findings:DHCR7 rs12785878 T&gt;C was found to be significantly associated with an increased risk of early-onset Alzheimer's disease (EOAD) (n = 300, risk allele C, adjusted OR = 1.542, adjusted 95% CI = 1.176–2.023, p = 0.002). There was no statistical significance of the other three SNPs between the two groups.Interpretation: Our results suggested that DHCR7 rs12785878 T&gt;C might be associated with an increased risk of EOAD in the Chinese population, while other polymorphisms related to vitamin D insufficiency might not be. However, due to the limited data in this study, replication studies in a larger sample are required.
Case Report: A Case of Acute Cellular Rejection Due to Atopic Dermatitis Exacerbation 3 Years After Heart Transplantation
Authors: Kakuda Nobutaka , Amiya Eisuke , Hatano Masaru , Maki Hisataka , Bujo Chie , Tsuji Masaki , Narita Koichi , Fujita Kanna , Ishida Junichi , Ono Minoru , Komuro Issei 
Published: February 2021

BackgroundLittle evidence has been presented about the association between previous atopic/allergic disease and graft rejection after solid organ transplantation. Thus, we present a case wherein acute cellular rejection (ACR) after heart transplantation (HTx) was noted along with exacerbation of atopic disease.Case SummaryA 32-year-old man was admitted at our hospital for regular monitoring of graft rejection. He had undergone heart transplant 3 years prior due to dilated cardiomyopathy. Echocardiogram revealed good biventricular function, and no abnormal findings were found in blood sampling tests. However, biopsy showed moderate ACR [Grade 2R(ISHLT 2004)/3A(ISHLT 1990)], which required twice-repeated steroid pulses with intensified immunosuppression. Meanwhile, his atopic dermatitis, which was diagnosed before having heart failure, was getting worse for the past 6 months. The exacerbation of atopic dermatitis was presumed to be related to the development of the intractable cellular rejection.DiscussionThis case suggested the association of atopic disease and graft rejection after HTx. We examined 76 patients from a cohort of previous studies who underwent HTx at our hospital, which suggested that patients with atopic/allergic disorders such as atopic dermatitis and asthma tended to have a significantly higher frequency of moderate rejection than non-allergic patients. (p = 0.012; Fisher’s exact test). Our case also suggests that exacerbation of atopic dermatitis might cause graft rejection of the transplanted organ, so that it is important to carefully evaluate the risk of graft rejection if there is a previous history of atopic/allergic disease.
Hysterectomy and Adnexal Procedures by Vaginal Natural Orifice Transluminal Endoscopic Surgery (VNH): Initial Findings From a Korean Surgeon
Authors: Kim Myeong-Seon , Noh Joseph J. , Kim Tae-Joong 
Published: February 2021

Objective: To evaluate feasibility and safety of hysterectomy and adnexal procedures by vaginal natural orifice transluminal endoscopic surgery (vNOTES).Study Design: This is a prospective observational study at a tertiary center and teaching University hospital. We enrolled prospectively 34 patients with benign diseases sequentially.Results: We measured baseline characteristics, surgical data, and pain score (VAS) after surgery. We surveyed before/after surgery. The time of port installation and each stage of surgery was measured. The learning curve was assessed through the graph according to the number of operations using linear and logarithmic regression curve estimation. The complications of surgery were investigated. The median age of the patients was 47.5 years (38–73). Median BMI was 22.4 (18.2–30.0). 20 cases of leiomyoma, four cases of adenomyosis, three cases of uterine prolapse, four cases of endometrial hyperplasia, and three cases of CIN were diagnosed. The median uterine weight was 180.0 g. The median port-installation time was 15.0 min (range, 4–35 min) and median total operation time was 85.5 min (range 43.0–132.0). Complications occurred in three patients. Two cases of bladder injury happened during vesicovaginal space dissection before the installation of the Wound Retractor (WR). One patient underwent transumbilical single-port surgery because of late-onset postoperative bleeding on the 13th postoperative day. The mean postoperative VAS scores were 3.36 immediately after surgery and 3.06, 2.79, and 2.45 at 6, 12, and 24 h after surgery, respectively. In continuous variable analysis, we detected a correlation between port-installation time and postoperative VAS ≥4 (pain score as need for medication). Based on a learning curve, port-installation time and total operation time appeared to reach the proficiency level by the 10th case.Conclusions: Although there were three complications, vNOTES offers advantages to patients and surgeons. More surgical techniques will be developed in vNOTES.
Machine Learning for the Prediction of Red Blood Cell Transfusion in Patients During or After Liver Transplantation Surgery
Authors: Liu Le-Ping , Zhao Qin-Yu , Wu Jiang , Luo Yan-Wei , Dong Hang , Chen Zi-Wei , Gui Rong , Wang Yong-Jun 
Published: February 2021

Aim: This study aimed to use machine learning algorithms to identify critical preoperative variables and predict the red blood cell (RBC) transfusion during or after liver transplantation surgery.Study Design and Methods: A total of 1,193 patients undergoing liver transplantation in three large tertiary hospitals in China were examined. Twenty-four preoperative variables were collected, including essential population characteristics, diagnosis, symptoms, and laboratory parameters. The cohort was randomly split into a train set (70%) and a validation set (30%). The Recursive Feature Elimination and eXtreme Gradient Boosting algorithms (XGBOOST) were used to select variables and build machine learning prediction models, respectively. Besides, seven other machine learning models and logistic regression were developed. The area under the receiver operating characteristic (AUROC) was used to compare the prediction performance of different models. The SHapley Additive exPlanations package was applied to interpret the XGBOOST model. Data from 31 patients at one of the hospitals were prospectively collected for model validation.Results: In this study, 72.1% of patients in the training set and 73.2% in the validation set underwent RBC transfusion during or after the surgery. Nine vital preoperative variables were finally selected, including the presence of portal hypertension, age, hemoglobin, diagnosis, direct bilirubin, activated partial thromboplastin time, globulin, aspartate aminotransferase, and alanine aminotransferase. The XGBOOST model presented significantly better predictive performance (AUROC: 0.813) than other models and also performed well in the prospective dataset (accuracy: 76.9%).Discussion: A model for predicting RBC transfusion during or after liver transplantation was successfully developed using a machine learning algorithm based on nine preoperative variables, which could guide high-risk patients to take appropriate preventive measures.
Evaluation of the Clinical Systems for Polymyxin Susceptibility Testing of Clinical Gram-Negative Bacteria in China
Authors: Zhu Ying , Jia Peiyao , Zhou Menglan , Zhang Jingjia , Zhang Ge , Kang Wei , Duan Simeng , Wang Tong , Xu Yingchun , Yang Qiwen 
Published: February 2021

ObjectivesThe performance of mainstream commercial antimicrobial susceptibility testing systems on polymyxins has not been well evaluated in China. In this study, three antimicrobial susceptibility testing systems were evaluated for polymyxin B and colistin.MethodsThe MICs of 257 Gram-negative strains collected from clinical cases and livestock were determined and analyzed. Using Broth Microdilution as the gold standard, the performance of VITEK 2® COMPACT, PhoenixTM M50, and Bio-kont AST System were evaluated. Essential agreement (EA), category agreement (CA), very major error (VME), and major error (ME) were calculated for comparison. The results of mcr-1 positive strains were separately discussed.ResultsThe EA, CA, VME, and ME to polymyxin B for Bio-kont were 83.5, 95.6, 13.1, and 0.6%, respectively. The EAs, CAs, VMEs, and MEs to colistin were as follows: Bio-kont, 86.7%/96.5%/7.2%/1.7%; Vitek 2, 64.2%/86.8%/41.0%/0%, and Phoenix M50, 92.9%/92.9%/21.7%/0%. The performance of Bio-kont to polymyxin B and colistin for Pseudomonas spp. (EA, CA &lt; 90%, VME &gt; 1.5%, ME = 5.6%/10%) and Enterobacter spp. (EA, CA &lt; 90%, VME &gt; 1.5% and ME = 0%), Vitek to colistin for most genera, and Phoenix to colistin for Enterobacter spp. (EA, CA &lt; 90%, VME &gt; 1.5%, ME = 0%) were unsatisfactory compared with other genera. The performance of Bio-kont to polymyxins for Escherichia spp. and Phoenix to colistin for Citrobacter spp., Escherichia spp., and Klebsiella spp., which all met the CLSI standard, were satisfactory. When the susceptibility of mcr-1 positive E. coli was tested, Bio-kont and Phoenix M50 presented excellent performance with no category errors, while Vitek 2 performed a high VME (25.5%).ConclusionWith relatively more accurate results for polymyxin B and colistin and lower VME, Bio-kont has an advantage in polymyxin antimicrobial susceptibility testing, especially for Escherichia spp., Klebsiella spp., Citrobacter spp. and Acinetobacter spp.
Outcome Prediction in Unresponsive Wakefulness Syndrome and Minimally Conscious State by Non-linear Dynamic Analysis of the EEG
Authors: Liu Baohu , Zhang Xu , Wang Lijia , Li Yuanyuan , Hou Jun , Duan Guoping , Guo Tongtong , Wu Dongyu 
Published: February 2021

Objectives: This study aimed to investigate the role of non-linear dynamic analysis (NDA) of the electroencephalogram (EEG) in predicting patient outcome in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS).Methods: This was a prospective longitudinal cohort study. A total of 98 and 64 UWS and MCS cases, respectively, were assessed. During admission, EEGs were acquired under eyes-closed and pain stimulation conditions. EEG nonlinear indices, including approximate entropy (ApEn) and cross-ApEn, were calculated. The modified Glasgow Outcome Scale (mGOS) was employed to assess functional prognosis 1 year following brain injury.Results: The mGOS scores were improved in 25 (26%) patients with UWS and 42 (66%) with MCS. Under the painful stimulation condition, both non-linear indices were lower in patients with UWS than in those with MCS. The frontal region, periphery of the primary sensory area (S1), and forebrain structure might be the key points modulating disorders of consciousness. The affected local cortical networks connected to S1 and unaffected distant cortical networks connecting S1 to the prefrontal area played important roles in mGOS score improvement.Conclusions: NDA provides an objective assessment of cortical excitability and interconnections of residual cortical functional islands. The impaired interconnection of the residual cortical functional island meant a poorer prognosis. The activation in the affected periphery of the S1 and the increase in the interconnection of affected local cortical areas around the S1 and unaffected S1 to the prefrontal and temporal areas meant a relatively favorable prognosis.