bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ochratoxin A and zearalenone in poultry feed samples from South China
Authors: Wang Qiongshan , Zhao Yarong , Chen Peirong , Zeng Rui , Liang Yunxiang 
Published: November 2021

AbstractData regarding ochratoxin A (OTA) and zearalenone (ZEA) contamination in feed in South China are limited. Here, we evaluated OTA and ZEA contamination in 514 poultry feed samples collected from South China. We validated a modified QuEChERS (quick, easy, cheap, effective, rugged, and safe) method and the mycotoxins were quantified by high‐pressure liquid chromatography–tandem mass spectrometry. OTA and ZEA were detected in 2.92% and 100% of the feed samples, respectively. Furthermore, 0%, 0.68%, and 7.0% of Hainan, Guangdong, and Guangxi feed samples were contaminated with OTA, at mean concentrations of 0.00, 1.14, and 0.88 μg/kg, respectively. All samples were contaminated with ZEA, and the mean concentrations were 2094.1, 14.3, and 8.73 μg/kg in the samples from Hainan, Guangdong, and Guangxi, respectively. The findings of this study indicate the strong need for intense monitoring of mycotoxin, especially ZEA, contamination in feed.
How to be a Universalist about Methods in African Philosophy
Authors: Irikefe Paul Oghenovo 
Published: November 2021

AbstractKwasi Wiredu argues for the metaphilosophical view, namely that an African orientation in philosophy can only be had through themes and issues of universal significance that are domesticated in African thought and culture. However, in this article, I challenge this claim. I argue that it grossly overlooks ways in which African philosophy already inherits methods of universal significance, which are applied to African problems and discourse. African philosophy so conceived is quite indistinguishable from African mathematics or physics.
Combined Radiation and Conduction in Glass Foams
Authors: Varady Mark J. , Fedorov Andrei G. 
Published: November 2021

Abstract
Understanding of heat transfer in glass foams and the development of theoretical tools for predicting heat transfer properties of glass foams is critical to improving the efficiency of glass manufacturing. In this paper, combined radiation and conduction heat transfer in a semitransparent glass foam layer is analyzed. The foam layer is bounded by hot combustion gases on top and glass melt on bottom. Heat transfer is assumed to be one-dimensional perpendicular to the plane-parallel foam layer. A previously developed model is used to calculate effective extinction coefficients and scattering phase function of the foam layer using a void size distribution and assuming all voids to be spherical. These radiation properties are then used along with a Schuster-Schwarzchild two flux approximation to solve the radiative transfer equation (RTE). A method for obtaining the effective thermal conductivity of the foam layer is also presented. The RTE and the energy conservation equations are simultaneously solved using a numerical iteration procedure. The effect of foam thickness and bubble size on the temperature distribution in the foam layer is studied.
Numerical Studies of Semiconductor Materials Solidification With Applied Electric and Magnetic Fields
Authors: Zhang Peng , Zheng Lili , Iseler Gerald , Bliss David 
Published: November 2021

Abstract
This paper presents one part of a concerted effort to understand the solidification and crystal growth of semiconductor materials using the bottom-seeded growth technique with externally applied electric and magnetic fields. A physics-based model is developed to study the gravitational (convection), thermoelectric (Peltier, Seebeck, Joule and Thomson) and magnetohydrodynamic (Lorentz force) effects on solidification phenomena. Several combinations of the magnitudes and directions of the two fields are studied. The calculated effects of the applied electrical and magnetic fields on the thermal distribution and position and shape of the solidification front are presented for bottom-seeded GaSb growth.
A Parallel HOFD Scheme for Direct Numerical Simulation of Turbulent Magnetically Driven Flows
Authors: Ai X. , Li B. Q. 
Published: November 2021

Abstract
Turbulent magnetically flows occur in a wide range of material processing systems involving electrically conducting melts. This paper presents a parallel higher order scheme for the direct numerical simulation of turbulent magnetically driven flows in induction channels. The numerical method is based on the higher order finite difference algorithm, which enjoys the spectral accuracy while minimizing the computational intensity. This, coupled with the parallel computing strategy, provides a very useful means to simulate turbulent flows. The higher order finite difference formulation of magnetically driven flow problems is described in this paper. The details of the parallel algorithm and its implementation for the simulations on parallel machines are discussed. The accuracy and numerical performance of the higher order finite difference scheme are assessed in comparison with the spectral method. The examples of turbulent magnetically driven flows in induction channels and pressure gradient driven flows in regular channels are given, and the computed results are compared with experimental measurements wherever possible.
Code status documentation at admission in COVID-19 patients: a descriptive cohort study
Authors: Briedé Saskia , van Goor Harriet M R , de Hond Titus A P , van Roeden Sonja E , Staats Judith M , Oosterheert Jan Jelrik , van den Bos Frederiek , Kaasjager Karin A H 
Published: November 2021

ObjectivesThe COVID-19 pandemic pressurised healthcare with increased shortage of care. This resulted in an increase of awareness for code status documentation (ie, whether limitations to specific life-sustaining treatments are in place), both in the medical field and in public media. However, it is unknown whether the increased awareness changed the prevalence and content of code status documentation for COVID-19 patients. We aim to describe differences in code status documentation between infectious patients before the pandemic and COVID-19 patients.SettingUniversity Medical Centre of Utrecht, a tertiary care teaching academic hospital in the Netherlands.ParticipantsA total of 1715 patients were included, 129 in the COVID-19 cohort (a cohort of COVID-19 patients, admitted from March 2020 to June 2020) and 1586 in the pre-COVID-19 cohort (a cohort of patients with (suspected) infections admitted between September 2016 to September 2018).Primary and secondary outcome measuresWe described frequency of code status documentation, frequency of discussion of this code status with patient and/or family, and content of code status.ResultsFrequencies of code status documentation (69.8% vs 72.7%, respectively) and discussion (75.6% vs 73.3%, respectively) were similar in both cohorts. More patients in the COVID-19 cohort than in the before COVID-19 cohort had any treatment limitation as opposed to full code (40% vs 25%). Within the treatment limitations, ‘no intensive care admission’ (81% vs 51%) and ‘no intubation’ (69% vs 40%) were more frequently documented in the COVID-19 cohort. A smaller difference was seen in ‘other limitation’ (17% vs 9%), while ‘no resuscitation’ (96% vs 92%) was comparable between both periods.ConclusionWe observed no difference in the frequency of code status documentation or discussion in COVID-19 patients opposed to a pre-COVID-19 cohort. However, treatment limitations were more prevalent in patients with COVID-19, especially ‘no intubation’ and ‘no intensive care admission’.
Novel open-source 3D-printed eye mount (TEMPO) for the ophthalmology wet lab
Authors: Mak Michael , Hong Yejun , Trask William Murray , Thompson Randy , Chung Helen , Warrian Kevin J 
Published: November 2021

ObjectiveProcuring an affordable eye mount that can stabilise a cadaveric eye and simulate a patient’s normal facial contours represents an ongoing challenge in the ophthalmology simulation wet lab, with notable limitations to all currently available commercial options. This project uses computer-assisted design and three-dimensional (3D)-printing techniques to tackle these challenges for ophthalmologic surgical training.Methods and AnalysisProof-of-concept study. Using Autodesk Fusion 360, we designed and 3D-printed a modular device that consists of 11 pieces forming a head structure. Standard OR tubing and syringes were adapted to create an adjustable-suction system to affix cadaveric eyes. Further modular inserts were customised to house non-cadaveric simulation eyes.ResultsThree-dimensional eye mount for procedures in ophthalmology (TEMPO) reliably fixed a cadaveric eye in stable position throughout surgical manipulation. Trainees were able to drape and practice appropriate hand positioning while corneal suturing. Overall, this model was affordable, at a cost of approximately $C200 to print. The modular nature renders individual pieces convenient for replacement and customisable to simulate regional anatomical variation and accommodate non-cadaveric eyes.ConclusionsTEMPO represents an affordable, high-fidelity alternative to existing commercially available eye mounts. It reliably fixates cadaveric and simulation eyes and provides an enhanced surgical training experience by way of its realistic facial contours. It is released as an open-source computer-aided design file, customisable to interested trainees with appropriate software and 3D-printing capacity.
Surgical outcomes of the Aurolab aqueous drainage implant (AADI) versus the Ahmed glaucoma valve for refractory paediatric glaucoma in Middle Eastern children
Authors: Khan Abdullah M , Ahmad Khabir , Alarfaj Motazz , Alotaibi Humoud , AlJaloud Ahmad , Malik Rizwan 
Published: November 2021

ObjectiveThe Aurolab aqueous drainage implant (AADI) has the potential advantages of less encapsulation and greater cost-effectiveness than the Ahmed glaucoma valve (AGV). The aim of this study was to compare the surgical success and outcomes of the AADI compared to the AGV in Middle-Eastern children.MethodsA comparative retrospective study of consecutive paediatric patients in a tertiary eye hospital was undertaken. Data collected included demographics, type of glaucoma, intraocular pressure (IOP), number of anti-glaucoma medications (AGMs) and any subsequent complications or further surgeries.AnalysisThe mean IOP, number of AGMs, surgical success and number of reoperations was compared for the two groups. Surgical success at each visit was defined as IOP of ≥6 mm Hg and ≤21 mm Hg or if the reduction of IOP was ≥20% reduced from baseline.ResultsA total of 126 tube surgeries (56 eyes in AADI and 70 eyes in AGV) were performed in patients aged ≤18 years from 2014 to 2019. No difference was observed in the mean IOP between the two groups except at the first month post-operative visit. After six months, the AADI group had a consistently significant lower mean number of AGMs. At last follow-up, 21 (37.5%) eyes in the AADI group were glaucoma medication-free vs 15 (21.4%) eyes in the AGV group (pp=0.047). Kaplan-Meier analysis showed equivalent cumulative probability of success at two years of 69.9% [(45.9%–84.9%)] for AADI vs 66.8% [(53.4%–77.1%])) for the AGV, respectively. Twenty-four eyes in the AGV group needed one or more subsequent surgeries, whereas 13 eyes needed one or more surgery in the AADI group.ConclusionsThis study shows an acceptable safety profile for the AADI in children, with a rate of failure that is comparable to the AGV, but less need for glaucoma re-operation or glaucoma medication in the first post-postoperative year.
Trends in hospital admissions for childhood fractures in England
Authors: Marson Ben Arthur , Manning Joseph C , James Marilyn , Ikram Adeel , Bryson David J , Ollivere Benjamin J 
Published: November 2021

PurposeFractures to the axial and appendicular skeleton are common in children causing loss of opportunities and disability. There are relatively few studies available to quantify the number of children who have their fractures diagnosed in the emergency department and are then admitted to hospital for ongoing management. The purpose of this study is to explore trends of frequency, types and age of children sustaining fractures who were admitted for intervention to National Health Service (NHS) hospitals.DesignThe study uses data from the Hospital Episode Statistics and Office for National Statistics from 2012 to 2019 to calculate the annual incidence of hospital admission for limb, spine, facial and skull fractures per 100 000 children.ResultsDuring 2012–2019, 368 120 children were admitted to English NHS hospitals with a fracture. 256 008 (69.5%) were upper limb fractures, 85 737 (23.3%) were lower limb fractures and 20 939 (5.7%) were skull or facial fractures. The annual incidence of upper limb fractures was highest in children aged 5–9 (348.3 per 100 000 children) and the highest incidence of lower limb fractures was in children aged 10–15 (126.5 per 100 000 children). The incidence of skull and facial fractures in preschool (age 0–4) children has been increasing at a rate of 0.629 per 100 000 children per year.ImplicationsThe annual incidence of hospital admission for fractures in children has been shown to be consistent for several fracture types between 2012 and 2019. An increasing trend of admissions with preschool skull fractures was observed, though the study data do not have sufficient granularity to demonstrate if this is due to changes in practice or to accidental or non-accidental causes.
A high dose of estrogen can improve renal ischemia-reperfusion-induced pulmonary injury in ovariectomized female rats
Authors: Nahavandi Samin , Ahmadi Saeedeh , Sobhani Seyed Alireza , Abbasi Tuba , Dehghani Aghdas 
Published: November 2021

Renal ischemia-reperfusion injury (RIRI) as a pathological process induces remote organ injury such as lung complications and it is regulated in a hormone-dependent manner. This study investigates the effect of estrogen on RIR-induced pulmonary injury in ovariectomized (OV) rats. A total of 60 female Wistar rats were divided into six groups: (i) intact sham, (ii) OV sham, (iii) OV sham + estradiol valerate (E), (iv) intact ischemia, (v) OV ischemia, and (vi) OV ischemia + E. Bilateral ischemia was performed for 45 min in all groups except sham. Before the ischemia, OV groups received an intramuscular (i.m.) injection of E. After reperfusion, blood samples were collected for serum analysis and kidney and lung tissue were separated for pathological experiment and malondialdehyde (MDA) and nitrite measurement. The left lung was weighed to measure pulmonary edema. Estrogen deficiency caused a greater increase in blood urea nitrogen and creatinine levels during IRI. Ischemia reduced nitrite of serum and lung tissue. The increased level of MDA during ischemia, returned to normal levels via estrogen injection. The severity of renal and lung damage in ischemic groups increased significantly, and estrogen improved this injury. Estrogen as an antioxidant agent can reduce oxidative stress and may improve renal function and ameliorating lung damage caused by RIR.
Karst hydrogeology of the Chalk and implications for groundwater protection
Authors: Maurice Louise , Farrant Andrew R. , Mathewson Ellie , Atkinson Tim 
Published: November 2021

Abstract

The Chalk is an unusual karst aquifer with limited cave development, but extensive networks of smaller solutional conduits and fissures enabling rapid groundwater flow. Small-scale karst features (stream sinks, dolines, dissolution pipes, and springs) are common, with hundreds of stream sinks recorded. Tracer velocities from 27 connections between stream sinks and springs have median and mean velocities of 4700 and 4600 m d
−1
. Tests to abstraction boreholes also demonstrate very rapid velocities of thousands of metres per day. Natural gradient tests from observation boreholes have rapid velocities of hundreds of metres per day. There is strong geological control on karst with dissolution focused on stratigraphical inception horizons. Surface karst features are concentrated near the Paleogene boundary, or where thin superficial cover occurs, but rapid groundwater flow is also common in other areas. The Chalk has higher storage and contaminant attenuation than classical karst, but recharge, storage and flow are influenced by karst. Point recharge through stream sinks, dolines, losing rivers, vertical solutional fissures, and soakaways enables rapid unsaturated zone flow. Saturated zone networks of solutional fissures and conduits create vulnerability to subsurface activities, and enable long distance transport of point source and diffuse pollutants, which may be derived from outside modelled catchment areas and source protection zones.
Longitudinal Copy-Number Alteration Analysis in Plasma Cell-Free DNA of Neuroendocrine Neoplasms is a Novel Specific Biomarker for Diagnosis, Prognosis, and Follow-up
Authors: Boons Gitta , Vandamme Timon , Mariën Laura , Lybaert Willem , Roeyen Geert , Rondou Tim , Papadimitriou Konstantinos , Janssens Katrien , Op de Beeck Bart , Simoens Marc , Demey Wim , Dero Isabel , Van Camp Guy , Peeters Marc , Op de Beeck Ken 
Published: November 2021

Abstract

Purpose:
As noninvasive biomarkers are an important unmet need for neuroendocrine neoplasms (NEN), biomarker potential of genome-wide molecular profiling of plasma cell-free DNA (cfDNA) was prospectively studied in patients with NEN.

Experimental Design:
Longitudinal plasma samples were collected from patients with well-differentiated, metastatic gastroenteropancreatic and lung NEN. cfDNA was subjected to shallow whole-genome sequencing to detect genome-wide copy-number alterations (CNA) and estimate circulating tumor DNA (ctDNA) fraction, and correlated to clinicopathologic and survival data. To differentiate pancreatic NENs (PNEN) from pancreatic adenocarcinomas (PAAD) using liquid biopsies, a classification model was trained using tissue-based CNAs and validated in cfDNA.

Results:
One hundred and ninety-five cfDNA samples from 43 patients with NEN were compared with healthy control cfDNA (N = 100). Plasma samples from patients with PNEN (N = 21) were used for comparison with publicly available PNEN tissue (N = 98), PAAD tissue (N = 109), and PAAD cfDNA (N = 96). Thirty percent of the NEN cfDNA samples contained ctDNA and 44% of the patients had at least one ctDNA-positive (ctDNA+) sample. CNAs detected in cfDNA were highly specific for NENs and the classification model could distinguish PAAD and PNEN cfDNA samples with a sensitivity, specificity, and AUC of 62%, 86%, and 79%, respectively. ctDNA-positivity was associated with higher World Health Organization (WHO) grade, primary tumor location, and higher chromogranin A and neuron-specific enolase values. Overall survival was significantly worse for ctDNA+ patients and increased ctDNA fractions were associated with poorer progression-free survival.

Conclusions:
Sequential genome-wide profiling of plasma cfDNA is a novel, noninvasive biomarker with high specificity for diagnosis, prognosis, and follow-up in metastatic NENs.
Relationship Between Serum Lipid Profiles and Carotid Intraplaque Neovascularization in a High–Stroke‐Risk Population: A Cross‐Sectional Study in China
Authors: Wang Ying , Yao Ming , Zou Mi , Ge Zhitong , Cai Siman , Hong Yuehui , Gao Luying , Zhang Li , Dong Yifan , Peng Bin , Wang Hongyan , Li Jianchu 
Published: November 2021

Background
Evidence of the association between serum lipid profiles and intraplaque neovascularization (IPN) is still limited. We aimed to study the value of a novel Doppler method, superb microvascular imaging, in correlating serum lipid profiles and evidence of IPN in a population with a high risk of stroke.

Methods and Results

A community‐based cross‐sectional study was conducted in Beijing, China. Residents (aged ≥40 years) underwent questionnaire interviews, physical examinations, and laboratory testing in 2018 and 2019. Subjects with a high risk of stroke were then selected. Standard carotid ultrasound and carotid plaque superb microvascular imaging examinations were then performed on the high–stroke‐risk participants. Logistic regression was used to evaluate the relationship between serum lipid profiles and carotid plaque IPN. Overall, a total of 250 individuals (mean age, 67.20±8.12 years; 66.4% men) met the study inclusion criteria. Superb microvascular imaging revealed carotid plaque IPN in 96 subjects (38.4%). Subjects with IPN were more likely to be current smokers (34.0% versus 46.9%,
P
=0.046), and their identified carotid plaques were much thicker (2.35±0.63 mm versus 2.75±0.80 mm,
P
=0.001). Serum lipids, including total cholesterol, non–high‐density lipoprotein cholesterol, and low‐density lipoprotein cholesterol were positively associated with the presence of IPN (4.33±1.00 mmol/L versus 4.79±1.12 mmol/L,
P
=0.001; 2.96±0.92 mmol/L versus 3.40±1.01 mmol/L,
P
=0.001; 2.18±0.76 mmol/L versus 2.46±0.80 mmol/L,
P
=0.005, respectively), and after adjustment for other confounders, the positive relationship remained significant. Furthermore, non–high‐density lipoprotein cholesterol (odds ratio, 2.62 [95% CI, 1.35–5.06]) was significantly associated with the presence of carotid plaque IPN even after adjusting for low‐density lipoprotein cholesterol.

Conclusions
Total cholesterol, non–high‐density lipoprotein cholesterol, and low‐density lipoprotein cholesterol were positively associated with the presence of carotid IPN in a Chinese high–stroke‐risk population. Further prospective studies should be conducted to better understand how much finding IPN adds to current stroke prediction tools.