bluuebunny/crossref_metadata_2025_split huggingface dataset:
EVALUASI PRESSURE DROP HEAT EXCHANGER-03 PADA CRUDE DISTILLATION UNIT PPSDM MIGAS CEPU
Authors: Prabaswara Reftian Jalu , Rulianah Sri , Sindhuwati Christyfani , Raharjo Raharjo 
Published: August 2021

Indonesia sebagai salah satu negara yang memiliki cadangan energi fosil melimpah tidak lepas dari konsumsi minyak bumi. PPSDM Migas Cepu merupakan salah satu instansi yang selain mengemban tugas dalam mempersiapkan tenaga-tenaga andal dalam bidang eksplorasi dan eksploitasi migas juga memiliki unit pengolahan minyak bumi yang menghasilkan beberapa produk turunan. Heat Exchanger-03 merupakan penukar panas yang berperan vital dalam proses produksi pada CDU PPSDM Migas. Penelitian ini bertujuan untuk mengetahui tingkat performa dari Heat exchanger-03 yang didasarkan pada perhitungan nilai pressure drop dan efisiensi perpindahan panas. Metodologi penelitian yang digunakan berupa pengamatan secara langsung selama 7 hari terhadap kondisi operasi HE-03 yang meliputi suhu, laju alir, dan tekanan fluida. Hasil dari evaluasi heat exchanger menunjukkan pressure drop pada sisi shell dan tube berturut-turut 0,00000175 dan 0,02462 psi. Efisiensi perpindahan panas sebesar 76,0242%. Berdasarkan penelitian ini dapat disimpulkan jika HE-03 beroperasi dengan layak namun telah mengalami penurunan kinerja. Oleh karena itu, pihak PPSDM Migas Cepu diharapkan untuk melakukan perawatan secara berkala yang meliputi pembersihan heat exchanger dan penggantian insulasi termal yang kurang layak untuk menjaga proses perpindahan panas tetap berjalan dengan baik.
SELEKSI PROSES DAN PENENTUAN KAPASITAS PABRIK KIMIA PEMBUATAN YOGURT DARI BAHAN BAKU KEDELAI
Authors: Widyono Muhammad Faturrahman , Hendrawati Nanik 
Published: August 2021

Kedelai merupakan salah satu komoditi tanaman pangan yang besar di Indonesia. Indonesia masih belum memiliki pabrik berskala besar yang memanfaatkan kedelai sebagai bahan untuk memproduksi yogurt. Dalam merencanakan Proses produksi pabrik kimia pembuatan yogurt kedelai perlu mempertimbangkan berbagai macam proses produksi, metode dan bahan yang paling efisien untuk menghasilkan produk yang optimal. Perhitungan kapasitas produksi harus lah di lakukan, perhitungan kapasitas produksi dilakukan dengan perhitungan kenaikan rata-rata kebutuhan produksi dengan menggunakan data yang telha tersedia setiap tahunnya, dengan penggunaan data 2014-2018 untuk mendapatkan perkiraan kapasitas produksi tahun 2024. Tujuan dari penelitian ini untuk menyeleksi beberapa proses, komposisi bahan dan waktu fermentasi pada pembuatan yogurt kedelai untuk mengetahui metode yang terbaik dan menentukan kapasitas produksi pabrik kimia yogurt kedelai yang pada tahun 2024. Hasil dari penelitian ini menunjukan bahwa metode produksi semi batch merupakan metode yang terbaik, dengan waktu fermentasi terbaik selama 8 jam, serta penggunaan campuran kultur merupakan proses produksi paling optimal, dan dengan kapasitas pabrik pada tahun 2024 sebesar 7000 ton/tahun.
PENGGUNAAN SERBUK TULANG AYAM SEBAGAI ADSORBEN DENGAN AKTIVATOR HCl DAN NaOH UNTUK MENGURANGI ION LOGAM KROMIUM
Authors: Ferriansyah Rizaldi Meydika , Hadiantoro Sigit 
Published: August 2021

Tulang ayam pada dasarnya bisa dimanfaatkan menjadi adsorben karena memiliki kandungan hidroksiapatit. Hidroksiapatit ini dapat dijadikan sebagai adsorben untuk pengolahan air limbah, karena banyak dan mudah diperbarui. Tujuan peneltitan ini untuk megetahui jenis aktivator HCl dan NaOH terhadap kemampuan adsorpsi ion logam kromium dari larutan K2Cr2O7, mengetahui pengaruh lama waktu aktivasi atau perendaman terhadap kemampuan adsorpsi ion logam kromium dari larutan K2Cr2O7, serta mengetahui perbedaan massa adsorben terhadap kemampuan adsorpsi ion logam kromium dari larutan K2Cr2O7. Metode penelitian ini menggunakan metode kuantitatif. Variabel bebas yang digunakan adalah larutan aktivator HCl 1M dan NaOH 1M, lama waktu aktivasi atau perendaman 12 dan 24 jam massa adsorben 0,5; 1; 1,5; dan 2 gram. variabel kontrol yaitu waktu proses adsorpsi 1 jam, volume larutan K2Cr2O7 100 ml, dan konsentrasi logam kromium 100 ppm. Hasil penelitian yang didapat yaitu larutan aktivasi yang optimum menggunakan HCl dengan lama waktu aktivasi 24 jam dan massa adsorben 2 gram menunujukkan efektivitas adsorpsi 87% dan terjadi penurunan konsentrasi kromium dari 99,620 ppm menjadi 13,219 ppm.
Pembuatan Game 2D Susun Terjemah Kosa Kata Bahasa Arab dengan Memanfaatkan Library A* Karya Aron Granberg
Authors: Yusuf Ansori  , Fadila Juniardi Nur , Fressy Nugroho  
Published: August 2021

Kemajuan teknologi memberikan banyak pengaruh di berbagai cabang. Salah satunya pada cabang game. Game merupakan salah satu bentuk kemajuan di bidang teknologi. Teknologi Game juga semakin berkembang dari masa ke masa dan semakin beragam maksud dan tujuan dalam pembuatannya. Dilihat dari sisi jenisnya, game dapat dibedakan game 3D dan 2D. Game 2D merupakan game dengan perspektif side-view, dimana pemain hanya dapat melihat karakter hanya dari satu sisi saja. Dari satu jenis game ini, dapat dibedakan menjadi banyak genre yang mempengaruhi karakter yang ada pada game. Pada umumnya setiap game akan terasa lebih menarik dan menantang jika terdapat non player character (NPC). Agar NPC dapat berperan sebagaimana karakter utama, maka diperlukan kecerdasan buatan. Salah satu kecerdasan buatan yang dapat digunakan adalah A* pathfinding. Dengan kecerdasan tersebut, NPC dapat mencari rute tercepat untuk berpindah dari satu titik ke titik lainnya. Pemaparan metode dan penjelasan pada penelitian disajikan secara detail dan sistematis agar mudah dipahami. Pada hasil diperlihatkan NPC yang mengejar karakter utama dan tugas karakter utama adalah mengalahkan semua NPC dan menemukan setiap huruf yang tersembunya di dalam game. Algoritma A Star (A*) terbukti dapat digunakan pada NPC di game 2 dimensi sehingga NPC dapat mengikuti karakter utama dan menyerang karena NPC berperan sebagai musuh dalam game
PREDICTION OF OZONE (O3) VALUES USING SUPPORT VECTOR REGRESSION METHOD
Authors: Chasandra Puspitasari  , Nur Rokhman  , Wahyono  
Published: August 2021

Tingginya jumlah kendaraan bermotor penyebab kemacetan menjadi faktor utama buruknya kualitas udara di kota-kota besar. Ozon (O3) merupakan salah satu indikator utama dalam mengukur tingkat polusi udara di Kota Surabaya untuk mengetahui bagaimana kualitas udaranya. Prediksi terhadap nilai Ozon (O3) penting dilakukan sebagai penunjang bagi masyarakat dan pemerintah dalam upaya peningkatan kualitas udara. Penelitian ini bertujuan memprediksi nilai Ozon (O3) berupa data time series menggunakan metode Support Vector Regression (SVR) dengan memanfaatkan kernel Linear, Polynomial, RBF, dan ANOVA. Data yang digunakan dalam penelitian adalah sebanyak 549 data primer dari rata-rata harian nilai Ozon (O3) kota Surabaya pada periode 1 Juli 2017 – 31 Desember 2018. Data tersebut akan digunakan dalam proses pelatihan dan pengujian hingga didapatkan hasil prediksi. Hasil yang diperoleh dari penelitian ini adalah kernel Linear menghasilkan model prediksi terbaik dengan nilai MAPE sebesar 21,78% dengan nilai parameter 𝜆 = 0,3; 𝜀 = 0,00001; cLR = 0,005; dan C = 0,5. Hasil dari kernel Polynomial tidak jauh berbeda dengan kernel Linear yaitu memiliki nilai MAPE sebesar 21,83%. Sedangkan kernel RBF dan ANOVA masing-masing menghasilkan model dengan nilai MAPE sebesar 24,49% dan 22,0%. Hasil tersebut menunjukkan bahwa metode SVR dengan kernel-kernel yang digunakan dapat memprediksi nilai Ozon dengan cukup baik.
Distribution, Prevalence, and Causative Agents of Fungal Keratitis: A Systematic Review and Meta-Analysis (1990 to 2020)
Authors: Ahmadikia Kazem , Aghaei Gharehbolagh Sanaz , Fallah Bahareh , Naeimi Eshkaleti Mahsa , Malekifar Pooneh , Rahsepar Saeedeh , Getso Muhammad I. , Sharma Savitri , Mahmoudi Shahram 
Published: August 2021

ObjectivesThis study aims to provide an overview of the prevalence, distribution, and causative agents of fungal keratitis.MethodsAll the articles with data on the prevalence of fungal keratitis among various patient groups from January 1, 1990 to May 27, 2020 were retrieved through a systematic search in PubMed, Scopus, Web of Science, and Google Scholar. Data were extracted, and the pooled estimated prevalence of fungal keratitis, yeast/mold infection, the spectrum and frequency of various causative agents, and the pooled estimated prevalence of mixed infections were calculated in general and in various countries (wherever possible) using meta-analysis.ResultsFrom 11,235 articles retrieved in the primary search step, 169 met the inclusion criteria. The 169 eligible articles were divided into six groups and analyzed separately. The pooled prevalence of fungal keratitis was variable with values ranging from 0.05% among postkeratoplasty patients to 43.01% among patients with a clinical suspicion of fungal keratitis. There was also a country-dependent variation in the prevalence (Paraguay: 50.1% (95% CI, 35.11, 65.00); Ireland: 1.1% (95% CI, 0.03, 6.04)). Except for postkeratoplasty cases (yeast: 51.80%), in all patient groups, molds were more common than yeasts. Although more than 50 distinct species of fungi have been found to cause fungal keratitis, Fusarium species followed by Aspergillus species were the most common causes of the disease. In general, 9.29% (95% CI, 6.52, 12.38) of fungal keratitis cases were mixed with bacterial agents.ConclusionThe prevalence of fungal keratitis can vary dramatically depending on the patient groups and geographical origin; however, the dominant causative agents are generally similar.
Gut Microbial Diversity in Female Patients With Invasive Mole and Choriocarcinoma and Its Differences Versus Healthy Controls
Authors: Liu Xiaomei , Pan Xue , Liu Hao , Ma Xiaoxin 
Published: August 2021

ObjectiveTo investigate variation in gut microbiome in female patients with invasive mole (IM) and choriocarcinoma (CC) and compare it with healthy controls.MethodsFecal microbiome of 12 female patients with IM, 9 female patients with CC, and 24 healthy females were analyzed based on 16s rDNA sequencing. Alpha (α) diversity was evaluated using Shannon diversity index and Pielou evenness index, while beta (β) diversity was assessed using principle coordinate analysis (PCoA) of unweighted Unifrac distances. The potential functional changes of microbiomes were predicted using Tax4Fun. The relative abundance of microbial taxa was compared using Welch’s t test. The role of varied gut microbiota was analyzed via receiver operating characteristic (ROC) curve.ResultsThe α diversity and β diversity were significantly different between IM patients and controls, but not between CC patients and controls. In addition, the abundance of cancer-related genes was significantly increased in IM and CC patients. Notably, a total of 19 families and 39 genera were found to have significant differences in bacterial abundance. ROC analysis indicated that Prevotella_7 may be a potential biomarker among IM, CC, and controls.ConclusionOur study demonstrated that the diversity and composition of gut microbiota among IM patients, CC patients, and healthy females were significantly different, which provides rationale for using gut microbiota as diagnostic markers and treatment targets, as well as for further study of gut microbiota in gestational trophoblastic neoplasia (GTN).
Tetravalent Influenza Vaccine Is Not Associated With Neuroaxonal Damage in Multiple Sclerosis Patients
Authors: Moser Tobias , Seiberl Michael , Feige Julia , Bieler Lara , Radlberger Richard F. , O’Sullivan Ciara , Pilz Georg , Harrer Andrea , Schwenker Kerstin , Haschke-Becher Elisabeth , Machegger Lukas , Grimm Jochen , Redlberger-Fritz Monika , Buchmann Arabella , Khalil Michael , Kvas Erich , Trinka Eugen , Wipfler Peter 
Published: August 2021

BackgroundEfficacy of vaccines and disease activity linked to immunization are major concerns among people with multiple sclerosis (pwMS).ObjectiveTo assess antibody responses to seasonal influenza antigens and vaccine-associated neuroaxonal damage utilizing serum neurofilament light chain (sNfL) in pwMS receiving dimethyl fumarate (DMF).MethodsIn this prospective study, the 2020/2021 seasonal tetravalent influenza vaccine was administered to 20 pwMS treated with DMF and 15 healthy controls (HCs). The primary endpoints were responder rate of strain-specific antibody production (seroconversion or significant (4-fold) increase in influenza-antibody titers for ≥2/4 strains) at 30 days post-vaccination and changes in sNfL levels.ResultsAll patients treated with DMF fulfilled the responder criteria for immunization compared with 53% of the controls. However, higher proportions of HCs already had influenza-antibody titers ≥1:40 at baseline (53% vs. 41%, p = 0.174). sNfL levels were comparable among both groups at baseline and did not increase 34 days after vaccination. In addition, no clinical or radiological disease reactivation was found.ConclusionDMF-treated patients mount an adequate humoral immune response to influenza vaccines. Within the limits of the small cohort investigated, our data suggest that influenza immunization is not associated with clinical or subclinical disease reactivation.
SIX1 Activation Is Involved in Cell Proliferation, Migration, and Anti-inflammation of Acute Ischemia/Reperfusion Injury in Mice
Authors: Jin Yong , Zhang Manling , Li Meishuang , Zhang Hong , Zhao Lihua , Qian Cheng , Li Shensen , Zhang Hao , Gao Min , Pan Binbin , Li Rongfeng , Wan Xin , Cao Changchun 
Published: August 2021

Nephrogenic proteins are re-expressed after ischemia/reperfusion (I/R) injury; however, the role of these proteins is still unknown. We found that sine oculis homeobox 1 (SIX1), a developmentally regulated homeoprotein, is reactivated in tubular epithelial cells after I/R injury associated with cell proliferation/migration and anti-inflammation. We demonstrated that SIX1 promoted cell proliferation by upregulating cyclin and glycolytic genes, and might increase cell migration by upregulating the expression of matrix metalloproteinase 9 (MMP9) directly or indirectly in the cell model. Notably, SIX1 targeted the promoters of the amino-terminal enhancer of split (AES) and fused in sarcoma (FUS), which are cofactors of nuclear factor-κB (NF-κB) subunit RELA, and then inhibited the transactivation function of RELA. The expression of monocyte chemotactic protein-1 (MCP-1) was decreased by the SIX1-mediated NF-κB pathway. Our results showed that the expression of cyclin, glycolytic genes, and MMP9 were significantly increased, and the infiltration of monocytes/macrophages (Mophs) was suppressed in SIX1 overexpression kidney at 1, 2, and 3 days after reperfusion. The overexpression of SIX1 resulted in reducing kidney damage from I/R injury in mice by promoting cell proliferation and migration and by inhibiting inflammation. Our study provides evidence that SIX1 involved in cell proliferation, migration, and anti-inflammation in the I/R model, which might be a potential therapeutic target that could be used to ameliorate kidney damage.
Association Between Efficacy of Immune Checkpoint Inhibitors and Sex: An Updated Meta-Analysis on 21 Trials and 12,675 Non-Small Cell Lung Cancer Patients
Authors: Xue Chongxiang , Zheng Shuyue , Dong Huijing , Lu Xingyu , Zhang Xu , Zhang Jingyi , Li Jia , Cui Huijuan 
Published: August 2021

BackgroundMounting randomized clinical trials have proved that immune checkpoint inhibitors (ICIs) achieved better overall survival (OS) and progression-free survival (PFS) than chemotherapy drugs for advanced non-small cell lung cancer (NSCLC) patients. However, some literatures have indicated that different sexes might not have equal immune response. Also, no agreement reached on the issue whether therapeutic benefit of ICIs is related to sex.ObjectivesTo explore the association between efficacy of ICIs for NSCLC patients and their sexes and summarize overall treatment-related adverse events (TRAEs) in an exploratory manner.MethodsWe performed this systematic review and meta-analysis of all potentially relevant studies retrieved from PubMed, EMBASE, and the Cochrane Library until June 2021, for eligible randomized controlled trials (RCTs) comparing immunotherapy with chemotherapy in advanced NSCLC patients. Literature screening, summary data extraction was performed independently and in duplicate. The pooled hazard ratio (HR) and 95% confidence interval (CI) of OS, PFS and TRAEs were calculated, applying STATA software and random-effects models. This study was registered in international prospective register of systematic reviews (PROSPERO), number CRD42020210797.ResultsTwenty-one trials involving 12,675 NSCLC patients were included. For patients with advanced NSCLC, ICIs significantly prolonged the OS (males: HR 0.73, 95%CI 0.67-0.79; females: HR 0.73, 95%CI 0.61-0.85) and PFS (males: HR 0.62, 95%CI 0.55-0.70; females: HR 0.68, 95%CI 0.55-0.81) versus chemotherapy. Overall, there was no statistical difference between their sexes (OS: P = 0.97; PFS: P = 0.43), respectively. Owing to insufficient TRAEs data of different sexes, we only found immunotherapy for NSCLC patients had more all-grades (RR 0.88; 95%CI 0.82-0.95) and 3-5 grades (RR 0.60; 95%CI 0.47-0.75) AEs compared with chemotherapy.ConclusionOur findings indicated that the interaction between immunotherapy efficacy and different sexes was equally evident. Overall, patients with NSCLC could obtain more benefits from ICIs than chemotherapy regimen regardless of their sexes.Systematic Review RegistrationPROSPERO (https://www.crd.york.ac.uk/prospero/), identifier CRD42020210797.
Somatization Symptoms Regulate Emotional Memory Bias in Adolescents With Major Depressive Disorder
Authors: Daming Mo , Xin Li , Shuwen Hu , Pengfei Guo , Shuai Liu , Feng Geng , Xiaomei Cao , Binbin Chen , Hui Zhong 
Published: August 2021

Objective: Somatization symptoms are commonly comorbid with depression. Furthermore, people with depression and somatization have a negative memory bias. We investigated the differences in emotional memory among adolescent patients with depressive disorders, with and without functional somatization symptoms (FSS).Methods: We recruited 30 adolescents with depression and FSS, 38 adolescents with depression but without FSS, and 38 healthy participants. Emotional memory tasks were conducted to evaluate the emotional memory of the participants in the three groups. The clinical symptoms were evaluated using the Hamilton Depression Rating Scale (HDRS) and the Children's Somatization Inventory (CSI).Results: The valence ratings and recognition accuracy rates for positive and neutral images of adolescent patients were significantly lower than those of the control group (F = 12.208, P &lt; 0.001; F = 6.801, P &lt; 0.05; F = 14.536, P &lt; 0.001; F = 6.306, P &lt; 0.05, respectively); however, the recognition accuracy rate for negative images of adolescent patients of depression without FSS was significantly lower than that of patients with FSS and control group participants (F = 10.316, P &lt; 0.001). These differences persisted after controlling for HDRS scores. The within-group analysis revealed that patients of depression with FSS showed significantly higher recognition accuracy rates for negative images than the other types (F = 5.446, P &lt; 0.05). The recognition accuracy rate for negative images was positively correlated with CSI scores (r = 0.352, P &lt; 0.05).Conclusion: Therefore, emotional memory impairment exists in adolescent patients of depression and FSS are associated with negative emotional memory retention.
Comparative Transcriptomics of Non-Embryogenic and Embryogenic Callus in Semi-Recalcitrant and Non-Recalcitrant Upland Cotton Lines
Authors: Kumar Sonika , Ruggles Ashleigh , Logan Sam , Mazarakis Alora , Tyson Thomas , Bates Matthew , Grosse Clayton , Reed David , Li Zhigang , Grimwood Jane , Schmutz Jeremy , Saski Christopher 
Published: August 2021

Somatic embryogenesis-mediated plant regeneration is essential for the genetic manipulation of agronomically important traits in upland cotton. Genotype specific recalcitrance to regeneration is a primary challenge in deploying genome editing and incorporating useful transgenes into elite cotton germplasm. In this study, transcriptomes of a semi-recalcitrant cotton (Gossypium hirsutum L.) genotype ‘Coker312’ were analyzed at two critical stages of somatic embryogenesis that include non-embryogenic callus (NEC) and embryogenic callus (EC) cells, and the results were compared to a non-recalcitrant genotype ‘Jin668’. We discovered 305 differentially expressed genes in Coker312, whereas, in Jin668, about 6-fold more genes (2155) were differentially expressed. A total of 154 differentially expressed genes were common between the two genotypes. Gene enrichment analysis of the upregulated genes identified functional categories, such as lipid transport, embryo development, regulation of transcription, sugar transport, and vitamin biosynthesis, among others. In Coker312 EC cells, five major transcription factors were highly upregulated: LEAFY COTYLEDON 1 (LEC1), WUS-related homeobox 5 (WOX5), ABSCISIC ACID INSENSITIVE3 (ABI3), FUSCA3 (FUS3), and WRKY2. In Jin668, LEC1, BABY BOOM (BBM), FUS3, and AGAMOUS-LIKE15 (AGL15) were highly expressed in EC cells. We also found that gene expression of these embryogenesis genes was typically higher in Jin668 when compared to Coker312. We conclude that significant differences in the expression of the above genes between Coker312 and Jin668 may be a critical factor affecting the regenerative ability of these genotypes.
Prácticas usuales y nuevas urgencias para una agenda de la promoción de la lectura
Authors: Bomibini Gustavo 
Published: August 2021

Se describen y anlizan algunas cuestiones que hacen a la construcción y puesta en prática de políticas públicas de promoción de la lectura desarolladas en el ámbito estatal,con cierto acento inevitable puesto en las particularidades que este tipo de prácticas asume en los países de la región latinoamericana.Referirse a la construcción de políticas públicas de lectura,no supone dar cuenta solo de aspectos específicamente técnico-políticos vinculados con la gestión, la planficación y la evaluación de este tipo de acciones sino también de poner de relieve algunas dimensiones culturales,téoricas ,pedagógicas u metodológicas que deben ser el presupuesto de trabajo de los aspectos antes mencionados .Se podría sostener que sobre la vieja agenda que prioriza la lectura y los planes de acciónm en pro de su promoción , se vuelve necesario discutir aspectos más generales de marco que nos permitan realizar una reconsideración del sentido de estas prácticas, de la definición de su especificidad y de sus posibles horizontes de impacto