bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surfactants Mediated Synthesis of Highly Crystalline Thin Films of Imine‐Linked Covalent Organic Frameworks on Water Surface
Authors: Ou Zhaowei , Liang Zihao , Dong Xin , Tan Fanglin , Gong Li , Zhao Pei , Wang Honglei , Liu Wei , Zheng Zhikun 
Published: September 2021

Main observation and conclusionImine‐linked covalent organic frameworks (COFs) have attracted extensive attention due to designable structures, tunable properties, and excellent thermal and chemical stability. They were typically obtained as insoluble and unprocessable powders, which seriously limits their full promise. Progress has been made in the synthesis of thin films of imine‐linked COFs by interfacial synthesis. However, the synthesis of highly crystalline, self‐supporting thin films of COFs remains challenging. Here, we employed a surfactants‐mediated method to synthesize such films at an air‐water interface, showed the films could be transferred onto arbitrary substrates on demand, and demonstrated the generality of the methodology with two different COFs. We found that the length of hydrophobic segments of surfactants played a key role in determination of the crystallinity and single crystalline domain size of the films. This work provides a feasible strategy to generate highly crystalline thin films of COFs.
Atrial structure and function in middle‐aged, physically‐active males and females: A cardiac magnetic resonance study
Authors: Glibbery Meghan , Banks Laura , Altaha Mustafa A. , Bentley Robert F. , Konieczny Kaja , Yan Andrew T. , Dorian Paul , Deva Djeven P. , Goodman Jack M. , Connelly Kim A. 
Published: September 2021

AbstractRecent studies have reported on an association between endurance sport, atrial enlargement and the development of lone atrial fibrillation in younger, male cohorts. The atrial morphology and function of middle‐aged, physically‐active males and females have not been well studied. We hypothesized that middle‐aged males would demonstrate larger left atrium (LA) and right atrium (RA) volumes compared to females, but atrial function would not differ. LA and RA volume and function were evaluated at rest in healthy adults, using a standardized 3.0Tesla cardiac magnetic resonance protocol. Physical activity, medical history, and maximal oxygen consumption () were also assessed. Physically‐active, middle‐aged men (n = 60; 54 ± 5 years old) and women (n = 30; 54 ± 5 years old) completed this study. Males had a higher body mass index, systolic blood pressure, andthan females (p < .05 for all), despite similar reported physical activity levels. Absolute and BSA and height‐indexed LA and RA maximum volumes were higher in males relative to females, despite no differences in ejection fractions (p < .05 for all). In multivariable regression, male sexp < .001) and(p = .004) were predictors of LA volume (modelR2 = 0.252), whereas(p < .001), male sex (p = .03), and RV EF (p < .05) were predictors of RA volume (modelR2 = 0.377). While middle‐aged males exhibited larger atrial volumes relative to females, larger, prospective studies are needed to explore the magnitude of physiologic atrial remodeling and functional adaptations in relation to phenotypic factors.
Variable fluid flow regimes alter human brain microvascular endothelial cell–cell junctions and cytoskeletal structure
Authors: Ranadewa Dilshan , Wu Jingwen , Subramanianbalachandar Vignesh A. , Steward Robert L. 
Published: September 2021

AbstractThe human brain microvasculature is constantly exposed to variable fluid flow regimes and their influence on the endothelium depends in part on the synchronous cooperative behavior between cell–cell junctions and the cytoskeleton. In this study, we exposed human cerebral microvascular endothelial cells to a low laminar flow (1 dyne⋅cm−2), high laminar flow (10 dyne⋅cm−2), low oscillatory flow (±1 dyne⋅cm−2), or high oscillatory flow (±10 dyne⋅cm−2) for 24 hr. After this time, endothelial cell–cell junction and cytoskeletal structural response was characterized through observation of zonula occludens‐1 (ZO‐1), claudin‐5, junctional adhesion molecule‐A (JAM‐A), vascular endothelial cadherin (VE‐Cad), and F‐actin. In addition, we also characterized cell morphology through measurement of cell area and cell eccentricity. Our results revealed the greatest change in junctional structure reorganization for ZO‐1 and JAM‐A to be observed under low laminar flow conditions while claudin‐5 exhibited the greatest change in structural reorganization under both low and high laminar flow conditions. However, VE‐Cad displayed the greatest structural response under a high laminar flow, reflecting the unique responses each cell–cell junction protein had to each fluid flow regime. In addition, cell area and cell eccentricity displayed most significant changes under the high laminar flow and low oscillatory flow, respectively. We believe this study will be useful to the field of cell mechanics and mechanobiology.
Seizures' impact on cognition and quality of life in childhood cancer survivors
Authors: Phillips Nicholas S. , Khan Raja B. , Li Chenghong , Mirzaei Salehabadi Sedigheh , Brinkman Tara M. , Srivastava Deokumar , Robison Leslie L. , Hudson Melissa M. , Krull Kevin R. , Sadighi Zsila S. 
Published: September 2021

BackgroundThe objective of this study was to determine the impact of seizure‐related factors on neurocognitive, health‐related quality of life (HRQOL), and social outcomes in survivors of childhood cancer.MethodsSurvivors of childhood cancer treated at St. Jude Children's Hospital (n = 2022; 48.3% female; median age, 31.5 years; median time since diagnosis, 23.6 years) completed neurocognitive testing and questionnaires. The presence, severity, resolution, and treatment history of seizures were abstracted from medical records. Adjusting for the age at diagnosis, sex, and prior cancer therapy, multivariable models examined the impact of seizures on neurocognitive and HRQOL outcomes. Mediation analyses were conducted for social outcomes.ResultsSeizures were identified in 232 survivors (11.5%; 29.9% of survivors with central nervous system [CNS] tumors and 9.0% of those without CNS tumors). In CNS tumor survivors, seizures were associated with poorer executive function and processing speed (P < .02); in non‐CNS tumor survivors, seizures were associated with worse function in every domain (P < .05). Among non‐CNS survivors, seizure severity was associated with worse processing speed (P = .023), and resolution was associated with better executive function (P = .028) and attention (P = .044). In CNS survivors, seizure resolution was associated with improved attention (P = .047) and memory (P < .02). Mediation analysis revealed that the impact of seizures on social outcomes was mediated by neurocognitive function.ConclusionsSeizures in cancer survivors adversely affect long‐term functional and psychosocial outcomes independently of cancer therapy. The resolution of seizure occurrence is associated with better outcomes. Seizure severity is associated with poorer outcomes and should be a focus of clinical management and patient education.
Exposure–Response Analyses for Therapeutic Dose Selection of Belantamab Mafodotin in Patients With Relapsed/Refractory Multiple Myeloma
Authors: Ferron‐Brady Geraldine , Rathi Chetan , Collins Jon , Struemper Herbert , Opalinska Joanna , Visser Sandra , Jewell Roxanne C. 
Published: September 2021

Belantamab mafodotin is an antibody–drug conjugate comprising a humanized anti‐B‐cell maturation antigen (BCMA) monoclonal antibody conjugated to monomethyl auristatin F (MMAF) via a protease‐resistant maleimidocaproyl linker. Single‐agent belantamab mafodotin showed clinically meaningful activity and manageable safety in patients with heavily pretreated relapsed/refractory multiple myeloma (RRMM) in the phase I DREAMM‐1 and phase II DREAMM‐2 studies and is approved by the US Food and Drug Administration and European Medicines Agency for RRMM treatment. To support monotherapy dose selection, the relationship between Cycle 1 exposure (derived using a population pharmacokinetic model) and clinical response (for multiple efficacy and safety end points) was explored. In DREAMM‐2, efficacy end points (probability of response (PoR) and progression‐free survival (PFS)) were associated with exposure in univariate evaluation; however, once disease burden factors were included in the model (e.g., baseline soluble BCMA, ß2‐microglobulin), exposure was no longer significant. Patients with higher disease burden had lower exposure. In DREAMM‐1, belantamab mafodotin exposure was the only variable to correlate with PoR and PFS. Probability of corneal events (keratopathy), but not dry eye or blurred vision, was strongly associated with belantamab mafodotin exposure (DREAMM‐2). Higher cys‐mcMMAF maximum plasma drug concentration (Cmax) and lower baseline platelet count were associated with increased probability of thrombocytopenia (DREAMM‐1 and DREAMM ‐2). In general, safety end points were more strongly associated with belantamab mafodotin exposure than efficacy end points, particularly after disease factors and patient characteristics were taken into account. Overall, these findings supported the monotherapy dose recommendation of belantamab mafodotin as 2.5 mg/kg every 3 weeks in patients with RRMM who have received four or more prior therapies.
Multiparental populations in line development: Genetic gain, diversity, and practical limitations
Authors: Bernardo Rex 
Published: September 2021

AbstractNew homozygous lines are usually developed from biparental crosses. To my knowledge, biparental and multiparental crosses have not been directly compared as breeding populations. My objective in this simulation study was to determine whether a set of several biparental populations or a single multiparental population is superior in terms of genetic gain and diversity of the best ensuing lines. Multiparental populations were simulated from p = 4, 6, and 8 parents and were compared with the corresponding p(p – 1)/2 biparental populations (i.e., diallel). Each of 250 quantitative trait loci had p alleles. Parental selection was mimicked via a Better Half model, wherein only the better crosses (e.g., four out of six with p = 4) were made. Genetic gains were equal between the Better Half model and the full diallel despite the larger population size with the latter. Current timelines for cultivar development in different species impose a limit on the number of generations available for creating multiparental populations, and the results indicated only a minimal (if any) increase in genetic gain when lines were developed from multiparental populations instead of biparental populations. The main benefit from multiparental populations was a better retention of genetic diversity among the selected lines. It remains to be seen whether this higher diversity among new lines from multiparental populations would lead to larger or more‐sustained gains in future lines.
Tuning Ligand‐Coordinated Single Metal Atoms on TiO2 and their Dynamic Response during Hydrogenation Catalysis
Authors: Zhou Xuemei , Sterbinsky George E. , Wasim Eman , Chen Linxiao , Tait Steven L. 
Published: September 2021

AbstractInvited for this month′s cover is the group of Steven Tait at Indiana University. The image shows single metal atoms stabilized by small molecules on a titanium dioxide powder support that are active in catalyzing ethylene hydrogenation. The Full Paper itself is available at 10.1002/cssc.202100208.
Novel Narrow Band Cyan‐Green Phosphor LiK7[Li3SiO4]8:Eu2+ with Enhanced Suppression of Second Broad Band Emission
Authors: Wimmer Daniel S. , Seibald Markus , Baumann Dominik , Peschke Simon , Wurst Klaus , Heymann Gunter , Dutzler Daniel , Garcia‐Fuente Amador , Urland Werner , Huppertz Hubert 
Published: September 2021

AbstractLiK7[Li3SiO4]8:Eu2+ (LKLSO:Eu2+) was synthesized by a high‐temperature solid‐state reaction. It is accessible from K2CO3, Li2O, SiO2, and an Eu‐source (Eu2O3) by conventional solid‐state reaction in nickel crucibles under a constant flow of forming gas. The crystal structure of LKLSO has been determined by single‐crystal X‐ray diffraction and it crystallizes in the tetragonal space group I
(no. 88) with the lattice parameters a=1560.83(5), c=1278.23(4) pm, and a volume of V=0.31140(2) nm3. The compound is isostructural to NaK7[Li3SiO4]8:Eu2+ but, in contrast, features an enhanced suppression of the second broad band emission through the specific channel filling in the crystal structure. Despite the observed positional disorder in the structure, the cyan‐green phosphor shows a narrow band emission with a maximum at 511 nm and a fwhm of 45 nm (0.215 eV).
Synthesis and Characterization of Cobalt NCN Pincer Complexes
Authors: Pecak Jan , Eder Wolfgang , Tomsu Gerald , Stöger Berthold , Pignitter Marc , Kirchner Karl 
Published: September 2021

AbstractA series of cobalt complexes, stabilized by a monoanionic tridentate NCN pincer ligand, was synthetized and characterized. Preparation of the paramagnetic 15 VE complex [Co(NCNCH2−Et)Br] (1) was accomplished by transmetalation of Li[2,6‐(Et2NCH2)2C6H3] with CoBr2 in THF. Treatment of this air‐sensitive compound with NO gas resulted in the formation of the diamagnetic Co(III) species [Co(NCNCH2−Et)(NO)Br] (2) as confirmed by X‐ray diffraction. This complex features a strongly bent NO ligand (Co−N−O∠135.0°). The νNO is observed at 1609 cm−1 which is typical for a bent metal‐N−O arrangement. Coordinatively unsaturated 1 could further be treated with pyridine, isocyanides, phosphines and CO to form five‐coordinate 17 VE complexes. Oxidation of 1 with CuBr2 led to the formation of the Co(III) complex [Co(NCNCH2−Et)Br2]. Treatment of [Co(NCNCH2−Et)Br2] with TlBF4 as halide scavenger in acetonitrile led to the formation of the cationic octahedral complex [Co(NCNCH2−Et)(MeCN)3](BF4)2. A combination of X‐ray crystallography, IR‐, NMR‐ and EPR‐spectroscopy as well as DFT/CAS‐SCF calculations were used to characterize all compounds.
Supporting systems transformation through design‐driven evaluation
Authors: Norman Cameron D. 
Published: September 2021

AbstractAs complexity in human social‐technical systems grows so does the need to provide useable guidance for how to effectively create change within them. A design‐driven approach to evaluation draws on lessons from complexity science and incorporates service and product design knowledge into the process of creating and implementing new knowledge or actions into a setting to produce value (innovation). This article introduces the fundamental tenets of a design‐driven evaluation (DDE) approach and illustrates its use in developing frameworks for evaluation that can support innovation and program development. Drawing on the science of systems and their application to evaluation, Developmental and Principles‐focused Evaluation, and systems‐oriented design theory and practice, a model for innovation development is proposed that will reframe program evaluation as both a service and product to aid system change.
Membrane‐destabilizing ionizable lipid empowered imaging‐guided siRNA delivery and cancer treatment
Authors: Guo Shuai , Li Kun , Hu Bo , Li Chunhui , Zhang Mengjie , Hussain Abid , Wang Xiaoxia , Cheng Qiang , Yang Feng , Ge Kun , Zhang Jinchao , Chang Jin , Liang Xing‐Jie , Weng Yuhua , Huang Yuanyu 
Published: September 2021

AbstractOne of the imperative medical requirements for cancer treatment is how to establish an imaging‐guided nanocarrier that combines therapeutic and imaging agents into one system. siRNA therapeutics have shown promising prospects in controlling life‐threatening diseases. However, it is still challenging to develop siRNA formulations with excellent cellular entry capability, efficient endosomal escape, and simultaneous visualization. Herein, we fabricated multifunctional ionizable lipid nanoparticles (iLNPs) for targeted delivery of siRNA and MRI contrast agent. The iLNPs comprises DSPC, cholesterol, PEGylated lipid, contrast agent DTPA‐BSA (Gd), and ionizable lipid termed iBL0104. siRNA‐loaded iLNPs (iLNPs/siRNA) could be decorated with a tumor targeting cyclic peptide (c(GRGDSPKC)) (termed GARP), or without targeting modification (termed GAP). Data revealed that GARP/siRNA iLNPs exhibited significantly higher cellular entry efficiency than GAP/siRNA iLNPs. GARP/siRNA iLNPs rapidly and effectively escaped from endosome and lysosome after internalization. Compared with GAP/siPLK1, GARP/siPLK1 exhibited better tumor inhibition efficacy in both cell‐line derived xenograft and liver cancer patient derived xenograft murine models. In addition, GARP formulation displayed ideal MRI effect in tumor‐bearing mice, and was well tolerated by testing animals. Therefore, this study provides an excellent example for achieving imaging‐guided and tumor‐targeted siRNA delivery and cancer treatment, highlighting its promising potential for translational medicine application.
Self‐powered technology based on nanogenerators for biomedical applications
Authors: Zhang Yuanzheng , Gao Xiangyang , Wu Yonghui , Gui Jinzheng , Guo Shishang , Zheng Haiwu , Wang Zhong Lin 
Published: September 2021

AbstractBiomedical electronic devices have enormous benefits for healthcare and quality of life. Still, the long‐term working of those devices remains a great challenge due to the short life and large volume of conventional batteries. Since the nanogenerators (NGs) invention, they have been widely used to convert various ambient mechanical energy sources into electrical energy. The self‐powered technology based on NGs is dedicated to harvesting ambient energy to supply electronic devices, which is an effective pathway to conquer the energy insufficiency of biomedical electronic devices. With the aid of this technology, it is expected to develop self‐powered biomedical electronic devices with advanced features and distinctive functions. The goal of this review is to summarize the existing self‐powered technologies based on NGs and then review the applications based on self‐powered technologies in the biomedical field during their rapid development in recent years, including two main directions. The first is the NGs as independent sensors to converts biomechanical energy and heat energy into electrical signals to reflect health information. The second direction is to use the electrical energy produced by NGs to stimulate biological tissues or powering biomedical devices for achieving the purpose of medical application. Eventually, we have analyzed and discussed the remaining challenges and perspectives of the field. We believe that the self‐powered technology based on NGs would advance the development of modern biomedical electronic devices.
Ameliorative effects of Cirsium japonicum extract and main component cirsimaritin in mice model of high‐fat diet‐induced metabolic dysfunction‐associated fatty liver disease
Authors: Che Denis Nchang , Shin Jae Young , Kang Hyun Ju , Cho Byoung Ok , Park Ji Hyeon , Wang Feng , Hao Suping , Sim Jae Suk , Sim Dong Jun , Jang Seon Il 
Published: September 2021

AbstractThe objective of this study was to determine biological effects of Cirsium japonicum extract and its main component cirsimaritin on high‐fat diet (HFD)‐induced metabolic dysfunction‐associated fatty liver disease (MAFLD) in a mouse model. Mice were fed with a HFD to induce MAFLD and simultaneously administered with C. japonicum extract (CJE) or cirsimaritin. Various MAFLD biomarkers were evaluated using biological methods. Results demonstrated that triglyceride, aspartate aminotransferase, alanine aminotransferase, and malondialdehyde levels in the liver of mice were significantly reduced upon administration of CJE or cirsimaritin. Treatment with CJE or cirsimaritin also reduced the severity of liver injury in the experimental mouse model of MAFLD by inhibiting hepatic steatosis, oxidative stress, inflammation, and liver fibrosis. These results demonstrate that CJE and cirsimaritin as its main compound have a preventive action against the progression of hepatic steatosis to fibrosis and cirrhosis. Our study suggests that CJE and cirsimaritin might be promising agents for preventing and/or treating MAFLD.
First lung transplant in Wuhan for a critical and elderly COVID‐19 patient
Authors: Wang Bo , Huang Jie , Hsin Micheal , Chen Jingyu , Lin Huiqing 
Published: September 2021

AbstractIntroductionWe report the case of a 65‐year‐old Coronavirus disease 2019 (COVID‐19) patient with pneumonia and subsequent end‐stage pulmonary failure who required 63 days of mechanical ventilation (MV) and 62 days of extracorporeal membrane oxygenation (ECMO).MethodsOn Day 45, a comprehensive interdisciplinary discussion on the best course of treatment resulted in the general consensus that his lungs would not recover. As such, he was evaluated and listed for a lung transplant.ResultsWe performed a bilateral lung transplant, and the patient was weaned off ECMO and MV postoperatively. This is the first report of lung transplants in patients with COVID‐19 in Wuhan.ConclusionsWe suggest that a lung transplantation may be a viable treatment for patients with end‐stage pulmonary failure secondary to COVID‐19 in selected situations.
Machine learning gene expression predicting model for ustekinumab response in patients with Crohn's disease
Authors: He Manrong , Li Chao , Tang Wanxin , Kang Yingxi , Zuo Yongdi , Wang Yufang 
Published: September 2021

AbstractBackgroundRecent studies reported the responses of ustekinumab (UST) for the treatment of Crohn's disease (CD) differ among patients, while the cause was unrevealed. The study aimed to develop a prediction model based on the gene transcription profiling of patients with CD in response to UST.MethodsThe GSE112366 dataset, which contains 86 CD and 26 normal samples, was downloaded for analysis. Differentially expressed genes (DEGs) were identified first. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were administered. Least absolute shrinkage and selection operator regression analysis was performed to build a model for UST response prediction.ResultsA total of 122 DEGs were identified. GO and KEGG analyses revealed that immune response pathways are significantly enriched in patients with CD. A multivariate logistic regression equation that comprises four genes (HSD3B1, MUC4, CF1, and CCL11) for UST response prediction was built. The area under the receiver operator characteristic curve for patients in training set and testing set were 0.746 and 0.734, respectively.ConclusionsThis study is the first to build a gene expression prediction model for UST response in patients with CD and provides valuable data sources for further studies.