bluuebunny/crossref_metadata_2025_split huggingface dataset:
Authenticity and Credibility in Science Communication Design: A Rhetorical Approach
Authors: Schneller Annina 
Published: October 2021

Abstract
The communication of scientific knowledge is traditionally oriented towards objective truth and facts, and builds on the authority of science. This article argues that, besides or even opposite to these aims, creating authenticity has become a major factor of successful science communication. Conveying a “personal touch,” or giving the audience a feeling of “being real,” are crucial promoters of credibility. Significant methods of gaining trust and sympathy on the level of textual as well as visual presentation are disclosed by exploring a bestselling popular scientific book, and with references to ancient rhetorical texts.
The Amplification of Madden–Julian Oscillation Boosted by Temperature Feedback
Authors: Chen Guosen 
Published: October 2021

Abstract
Due to a small Coriolis force in tropics, the theoretical study of Madden–Julian oscillation (MJO) often assumes weak temperature gradient balance, which neglects the temperature feedback (manifested in the temperature tendency term). In this study, the effect of the temperature feedback on the MJO is investigated by using the MJO trio-interaction model, which can capture the essential large-scale features of the MJO. The scale analysis indicates that the rotation effect is strong for the MJO scales, so that the temperature feedback is as important as the moisture feedback (manifested in the moisture tendency term); the latter is often considered to be critical for MJO. The experiments with the theoretical model show that the temperature feedback has significant impact on the MJO’s maintenance. When the temperature feedback is turned off, the simulated MJO cannot be maintained over the warm pool. This is because the temperature feedback could boost the energy generation. Without the temperature feedback, only the latent heat can be generated. With the temperature feedback, not only the latent heat but also the enthalpy (and therefore the available potential energy) can be generated. Therefore, the total energy generation is more efficient with the temperature feedback, favoring the self-maintenance of the MJO. Further investigation shows that this effect of the temperature feedback on MJO amplification can be inferred from observations. The findings here indicate that the temperature feedback could have nonnegligible impacts on the MJO and have implications in the simulation of MJO.
The Impact of Training on Human–Autonomy Team Communications and Trust Calibration
Authors: Johnson Craig J. , Demir Mustafa , McNeese Nathan J. , Gorman Jamie C. , Wolff Alexandra T. , Cooke Nancy J. 
Published: October 2021

Objective This work examines two human–autonomy team (HAT) training approaches that target communication and trust calibration to improve team effectiveness under degraded conditions. Background Human–autonomy teaming presents challenges to teamwork, some of which may be addressed through training. Factors vital to HAT performance include communication and calibrated trust. Method Thirty teams of three, including one confederate acting as an autonomous agent, received either entrainment-based coordination training, trust calibration training, or control training before executing a series of missions operating a simulated remotely piloted aircraft. Automation and autonomy failures simulating degraded conditions were injected during missions, and measures of team communication, trust, and task efficiency were collected. Results Teams receiving coordination training had higher communication anticipation ratios, took photos of targets faster, and overcame more autonomy failures. Although autonomy failures were introduced in all conditions, teams receiving the calibration training reported that their overall trust in the agent was more robust over time. However, they did not perform better than the control condition. Conclusions Training based on entrainment of communications, wherein introduction of timely information exchange through one team member has lasting effects throughout the team, was positively associated with improvements in HAT communications and performance under degraded conditions. Training that emphasized the shortcomings of the autonomous agent appeared to calibrate expectations and maintain trust. Applications Team training that includes an autonomous agent that models effective information exchange may positively impact team communication and coordination. Training that emphasizes the limitations of an autonomous agent may help calibrate trust.
The Psychometric Properties for the Test of Perceived Physical Competence for Youths with Visual Impairments
Authors: Brian Ali , Starrett Angela , Ross Robbie , Pennell Adam , Gilbert Emily , Miedema Sally Taunton , Casner Chandler , Lieberman Lauren J. 
Published: October 2021

Introduction Limited inquiries exist for perceptions of physical competence for people with visual impairments, since there are no specific, psychometrically tested scales. The purpose of this study was to establish the psychometric properties of the Test of Perceived Physical Competence (TPPC) for individuals with visual impairments aged 9–19 years. Methods: Experts ( N = 12) provided feedback for content and face validity. Then, after assessing 179 individuals with visual impairments, McDonald’s Omega, and Confirmatory Factor Analyses were used to evaluate the internal consistency and structure. Finally, results of the TPPC were compared with the Self-Perception Profiles for Children/Adolescents for divergent validity. Results: The standardized root mean square residual result of 0.053 and the Comparative Fit Index result of 0.95 indicated acceptable fit. The percent of variation in each item explained by the factor varied from 44% (item 3) to 63% (item 6). McDonald’s Omega for the one-factor scale is 0.987, and the perceived physical competence subscale of the Self-Perception Profiles for Children and TPPC have a Spearman correlation coefficient of 0.469 (95% confidence interval = 0.269–0.630). Discussion: Having a psychometrically strong scale to measure perceived physical competence of individuals with visual impairments is the first step in being able to replicate current, seminal research among this unique population. This adaptation of Harter’s perceived physical competence subscale uniquely assesses the child’s perceptions of physical competence among peers with visual impairments. This measure, coupled with the power to examine its predictive abilities, is important for children and adolescents with visual impairments, since they possess great tendencies for obesity and sedentary behavior. Implications for practitioners: If practitioners would like to change tendencies for obesity and sedentary behavior, then, they must include perceptions of physical competence as a latent construct. Now, practitioners can feel confident to do so for this highly vulnerable population.
Characteristics of repeated recidivism in surgical cases of cholesteatoma requiring canal wall reconstruction
Authors: Yazama Hiroaki , Kunimoto Yasuomi , Hasegawa Kensaku , Watanabe Tasuku , Fujiwara Kazunori 
Published: October 2021

Objective Few reports discuss the characteristics of repeated recidivism of cholesteatoma. We describe the clinical characteristics of patients with cholesteatoma who experienced at least two recidivism episodes after initial surgery for cholesteatoma requiring canal wall reconstruction. Methods We reviewed the medical records of 11 patients who underwent surgery for cholesteatoma with canal wall reconstruction at our department between April 2008 and March 2018 and subsequently experienced two relapses that necessitated revision surgery involving tympanomastoidectomy with canal reconstruction. Patient age at the time of the first surgery ranged from 6 to 56 (mean, 25.7) years. Seven (63.6%) of the 11 patients were male. These 11 patients were classified according to the type of recidivism, and their characteristics (pathology, operation date, operation method, pattern of relapse, and position of recurrence) were investigated. Results Four cases involved secondary residual cholesteatoma, with the mean interval between the first revision surgery and the second revision surgery being 23.8 (range, 11–39) months. Secondary residual sites included the anterior tympanic cavity, tympanic sinus, and anterior end of the reconstructed cartilage of the canal wall. The other seven cases involved secondary recurrence, with the mean interval between the first and the second revision surgery being 26.1 (range, 12–57) months. The sites of recurrence were at the edges of the reconstructed cartilage. One notable case involved the cartilage junction, leading us to hypothesize that retraction of the temporal muscle flap and the patulous Eustachian tube was the underlying cause. Conclusion For residual cholesteatoma, strict measures are necessary to maintain the operation under clear view, and more careful follow-up is necessary in patients who have had previous surgery at another hospital. For recurrent cholesteatoma, it was recognized that Eustachian tube function must be ascertained in advance, and careful observation of the reconstructed cartilage edge is necessary.
Clinical monitoring of activated clotting time during cardiothoracic surgery: comparing the Hemochron® Response and Hemochron® Signature Elite
Authors: Hoffmann Roland F , Horsten Sandra , Mariani Massimo A , de Vries Adrianus J 
Published: October 2021

Introduction: The Activated Clotting Time (ACT) is commonly used to manage anticoagulation during cardiac surgery. The aim of this study was to compare the older manually operated Hemochron® Response and the automated Hemochron® Signature Elite. Methods: In this observational study the clinically relevant differences of both devices were investigated simultaneously, using duplicate measurements, in 29 patients who underwent a Coronary Artery Bypass Grafting (CABG) or Aortic Valve Replacement (AVR) in order to determine reliability, bias, and to detect which method has the lowest variation. Blood samples were obtained from the arterial line prior to surgery, after administration of 300 IU/kg heparin, 5 minutes after initiation of cardiopulmonary bypass and successively every 30 minutes, and after protamine administration. Results: A total of 202 measurements were performed. Of these 10 measurements were out of range in the Response and 9 in the Elite. About 27 single unstable magnet errors were seen in the Response versus no measurement errors in the Elite. No statistically significant differences between the Response (p = 0.22, Wilcoxon rank) and Elite (p = 0.064) duplicates were observed. The Response values were consistently higher during heparinization than the Elite measurements (p = 0.002, repeated measurements) with an average positive bias of around 56 seconds during heparinization (Bland-Altman). Overall, the coefficient of variation (CoV) increased during heparinization. Conclusion: The Elite was more reliable, but the variation was higher for the Elite than the Response. The observed positive bias in the Response compared to the Elite could affect heparin administration during surgery making the two systems not interchangeable.
An online international comparison of palliative care identification in primary care using the Surprise Question
Authors: White Nicola , Oostendorp Linda JM , Vickerstaff Victoria , Gerlach Christina , Engels Yvonne , Maessen Maud , Tomlinson Christopher , Wens Johan , Leysen Bert , Biasco Guido , Zambrano Sofia , Eychmüller Steffen , Avgerinou Christina , Chattat Rabih , Ottoboni Giovanni , Veldhoven Carel , Stone Patrick 
Published: October 2021

Background: The Surprise Question (‘Would I be surprised if this patient died within 12 months?’) identifies patients in the last year of life. It is unclear if ‘surprised’ means the same for each clinician, and whether their responses are internally consistent. Aim: To determine the consistency with which the Surprise Question is used. Design: A cross-sectional online study of participants located in Belgium, Germany, Italy, The Netherlands, Switzerland and UK. Participants completed 20 hypothetical patient summaries (‘vignettes’). Primary outcome measure: continuous estimate of probability of death within 12 months (0% [certain survival]–100% [certain death]). A threshold (probability estimate above which Surprise Question responses were consistently ‘no’) and an inconsistency range (range of probability estimates where respondents vacillated between responses) were calculated. Univariable and multivariable linear regression explored differences in consistency. Trial registration: NCT03697213. Setting/participants: Registered General Practitioners (GPs). Of the 307 GPs who started the study, 250 completed 15 or more vignettes. Results: Participants had a consistency threshold of 49.8% (SD 22.7) and inconsistency range of 17% (SD 22.4). Italy had a significantly higher threshold than other countries ( p = 0.002). There was also a difference in threshold levels depending on age of clinician, for every yearly increase, participants had a higher threshold. There was no difference in inconsistency between countries ( p = 0.53). Conclusions: There is variation between clinicians regarding the use of the Surprise Question. Over half of GPs were not internally consistent in their responses to the Surprise Question. Future research with standardised terms and real patients is warranted.
In Support of a Renewable Energy and Materials Economy: A Global Green New Deal That Includes Arctic Sea Ice Triage and Carbon Cycle Restoration
Authors: Baiman Ron 
Published: October 2021

A Global Green New Deal (GGND)—that includes Arctic sea ice climate triage and carbon cycle climate restoration, and that, following Eisenberger (2020), would move us toward a renewable energy and materials economy (REME)—is necessary to turn our current civilization and species-threatening climate crises into an opportunity to stabilize our planet’s climate and advance to a new, more equitable and prosperous stage of human development. Imminent, potentially catastrophic, global climate impacts of Arctic sea ice loss, the first global climate “tipping point,” are reviewed, and practical and efficient potential climate triage methods for avoiding this are summarized. Longer-term carbon dioxide removal (CDR) and carbon capture, sequestration, and use (CCSU) methods, that would move us toward long-term carbon cycle climate restoration, are presented. A general reframing of climate policy and specific GGND policy proposals—that include Arctic sea ice climate triage and carbon cycle climate restoration that would rapidly move us toward a REME and avoid increasingly catastrophic climate impacts—are proposed. JEL Classification: Q53, Q54, Q55, Q56, Q58
Risk of Gastrointestinal Bleeding on Treatment With Statin Alone or With Concomitant Administration of Warfarin: A Systematic Review and Meta-analysis of 5.3 Million Participants
Authors: Bhagavathula Akshaya Srikanth , Vidyasaga Kota , Gebreyohannes Eyob Alemayehu , Tesfaye Wubshet 
Published: October 2021

Objective: This study aimed to comprehensively evaluate the risk of gastrointestinal bleeding (GIB) with statin monotherapy or with concomitant warfarin use. Data Sources: PubMed, Web of Science, and EMBASE (via Scopus) were searched for observational studies that reported the risk of GIB in adults on statin therapy or with concomitant warfarin use until August 28, 2021. Study Selection and Data Extraction: Observational studies evaluating the risk of GIB in adults (age >18 years) on statin medication or concomitant use with warfarin were included. Data Synthesis: In all, 14 studies with a total of 5 235 123 participants, reporting 48 677 GIB events (43 734 from statin users and 4943 from users of statin combined with warfarin), were included in the analyses. The pooled analysis revealed no difference in the risk of GIB with statin monotherapy (relative risk [RR]: 0.65; 95% CI: 0.42-1.02) or concomitant statin + warfarin use (RR: 0.97; 95% CI: 0.91-1.02). Prior use of statin was not associated with GIB risk (RR: 0.88; 95% CI: 0.63-1.22), whereas a shorter duration of statin use (<5 years) was associated with a lower risk of GIB (RR: 0.42; 95% CI: 0.18-0.97). Relevance to Patient Care and Clinical Practice: This analysis provides strong evidence on the association between statin use (with/without warfarin) and risk of GIB. Conclusion: Statin alone or combined with warfarin was not significantly associated with either an increased or decreased risk of GIB. The GIB risk was significantly lower when statins were used for a short duration (<5 years). The putative relationship between statins and GIB in warfarin users warrant further investigation.
Long-term efficacy and safety of inebilizumab in neuromyelitis optica spectrum disorder: Analysis of aquaporin-4–immunoglobulin G–seropositive participants taking inebilizumab for ⩾4 years in the N-MOmentum trial
Authors: Rensel Mary , Zabeti Aram , Mealy Maureen A , Cimbora Daniel , She Dewei , Drappa Jorn , Katz Eliezer 
Published: October 2021

Background: Efficacy and safety of inebilizumab for treatment of neuromyelitis optica spectrum disorder in adults seropositive for aquaporin-4 (AQP4)–immunoglobulin (Ig) G were demonstrated in the 28-week randomized controlled period of the N-MOmentum study. Objective: To assess efficacy and safety of long-term inebilizumab treatment. Methods: Post hoc analysis was performed in 75 AQP4–IgG–seropositive participants receiving inebilizumab for ⩾4 years in the randomized controlled period and open-label extension of the N-MOmentum study. Results: Eighteen attacks occurred in 13 participants during inebilizumab treatment (annualized attack rate, 0.052 attacks/person-year). Twelve attacks occurred during the first year of treatment, and two each occurred in years 2–4. Disability scores remained stable throughout ⩾4 years of treatment. Inebilizumab was well tolerated, with two (2.7%) serious treatment-emergent adverse events related to inebilizumab and no deaths. Immunoglobulin G levels decreased over time; however, correlation between severe infections and low IgG levels could not be determined because of their small numbers. Conclusion: These results from the N-MOmentum study continue to support use of inebilizumab for treatment of neuromyelitis optica spectrum disorder. Furthermore, the findings suggest that efficacy of inebilizumab may be enhanced after the first year of treatment, warranting additional long-term investigation.
Reduced physical activity and weight gain are associated with an increase of depressive symptoms during the COVID-19 pandemic. A general practitioners’ prospective observational study
Authors: Wernhart Simon , Weihe Eberhard , Rassaf Tienush 
Published: October 2021

Objectives We aimed to assess associations between depressive symptoms, lifestyle, and somatic symptoms during the COVID-19 pandemic. Design A prospective, observational study using a self-designed questionnaire. Setting Three general practitioners’ (GP) offices in rural Germany. Participants 271 adult patients without manifest cardiovascular or pulmonary disease with (n = 82) and without (n = 189) hypertension reporting to our GP offices. Main outcome measures The reported increase of depressive symptoms (loneliness, sleeplessness, joylessness, listlessness) prior to the first documented case in Germany on 27.01.2020 (t0) as opposed to patients’ health perception during the Corona pandemic (t1) was the primary outcome measure. The secondary outcome measures were changes in physical activity (PA), dyspnea and angina in the two groups. Results Out of 271 patients (50.8 ± 16.8 years, 55.1% females), 1.5% were tested positive for COVID-19. Overall, listlessness (8.5%, p = 0.001), sleeplessness (5.2%, p = 0.001) and joylessness (4.2%, p = 0.003) were increased. Dyspnea significantly increased (9.2%, p < 0.001) and employment status worsened (6.5%, p < 0.001). There were significant associations between the increase of depressive symptoms, weight increase (p = 0.017), and reduction in physical activity (p = 0.046). However, after adjusting for age, hypertensive patients did not show more depressive symptoms (p = 0.704), dyspnea (p = 0.063) or angina (p = 0.432), nor was there any difference in PA (p = 0.906) compared to healthy individuals. Conclusions We demonstrate an association between the deterioration of depressive symptoms, weight gain, and reduced physical activity during COVID-19, both in hypertensives and healthy controls. Hypertension is no driver of symptom deterioration during the pandemic. The trial was registered in the German Clinical Trials Registry (DRKS00022157).
Patients who are admitted to the Department of Internal Medicine with a very low C-reactive protein concentration
Authors: Feigin Eugene , Levinson Tal , Berliner Shlomo , Zeltser David , Itzhak Shapira , Shenhar-Tsarfaty Shani , Egoz Eyal , Meilik Ahuva , Goldiner Ilana , Rogowski Ori , Wasserman Asaf 
Published: October 2021

Introduction C-reactive protein (CRP) is a marker commonly used in clinical practice as a reference for the inflammatory activity in vivo. Low levels are often associated with good health and lower risk for adverse outcomes. Patients and methods We examined medical records of the last 6 years, of all patients admitted for hospitalization in internal medicine wards who had the first CRP measurement below ≤ 0.03 mg/L (detection limit). Diagnosis criteria and 7 days’ survival were reviewed. Results Out of 61,590 total admissions to internal medicine wards, three hundred and thirteen patients had CRP equal to or lower than 0.03 mg/L (0.5%). Second CRP measurement revealed gradual increment up to 10.8 ± 35.4 mg/L. Four patients died within 7 days from admission. Discussion Presentation to the internal medicine department with a very low concentration of CRP is highly unusual, but it does not exclude the existence of significant acute morbidities. Clinicians should take additional CRP tests before any conclusion is considered regarding the presence or absence of an inflammatory response.