bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Authors: Demirdizen Engin , Al-Ali Ruslan , Narayanan Ashwin , Sun Xueyuan , Varga Julianna Patricia , Steffl Bianca , Brom Manuela , Krunic Damir , Schmidt Claudia , Schmidt Gabriele , Bestvater Felix , Taranda Julian , Turcan Şevin 
Published: November 2021

AbstractOligodendrogliomas are a subtype of isocitrate dehydrogenase (IDH) mutant gliomas defined by the co-deletion of chromosome arms 1p and 19q. Although the somatic genomic alterations of oligodendrogliomas have been well described, transcriptional changes unique to these tumors are not well studied. Here, we identify Tripartite Motif Containing 67 (TRIM67), an E3 ubiquitin ligase with essential roles during neuronal development, as an oncogene distinctly upregulated in oligodendrogliomas. We characterize the function of TRIM67 using high throughput assays, including RNA sequencing, total lysate-mass spectrometry (MS) and co-immunoprecipitation (IP)-MS using human neural progenitor cells and patient-derived glioma tumorspheres constitutively overexpressing TRIM67. Our high throughput data suggest that TRIM67 overexpression alters the abundance of cytoskeletal proteins, which were validated by functional assays, including immunofluorescence (IF) staining, co-IP and western blotting (WB). Additionally, IF staining results indicate that TRIM67 ectopic expression induces formation of membrane blebs in glioma cells, which could be reverted with the nonmuscle class II myosin inhibitor blebbistatin and selective ROCK inhibitor fasudil. GTP pulldown and WB assays further indicate that Rho GTPase/ROCK2 signaling is altered upon TRIM67 ectopic expression. Phenotypically, TRIM67 expression resulted in higher cell motility in wound healing experiments, reduced cell adherence in adhesion assays, accelerated tumor growth and reduced survival in mouse orthotopic implantation models of an oligodendroglioma-derived patient tumorsphere line. Taken together, our results demonstrate that upregulated TRIM67 induces blebbing-based rounded cell morphology through Rho GTPase/ROCK-mediated signaling thereby contributing to glioma pathogenesis.SignificanceWe identify TRIM67 as a novel oncogene in oligodendroglioma that leads to increased cell motility, tumor growth, reduced adhesion, and survival in mice. Our results also show that constitutive TRIM67 expression transforms cell morphology from an adherent to a rounded appearance with membrane blebs. Mechanistic alteration of actin cytoskeleton and Rho GTPase signaling upon TRIM67 upregulation underlies the rounded cell structure and the membrane blebbing phenotype. TRIM67-induced blebbing is specifically regulated by RHOA-RAC1-ROCK2 signaling axis. TRIM67 overexpression also alters pathways associated with cell migration and wound healing in various glioma cell lines and human neural progenitor cells, suggesting a general oncogenic mechanism in gliomas. Overall, our study highlights TRIM67 as a novel player orchestrating cytoskeleton, Rho GTPase signaling and bleb-based cell movement, ultimately causing tumorigenic outcomes in oligodendrogliomas.
Evaluating anti-poverty policy efficiencies in China: meta-frontier analysis using the two-stage data envelopment analysis model
Authors: Yang Guotao , Wang Yue , Chang Huibin , Chen Qinghua 
Published: November 2021

PurposeThis study examines the relative efficiencies of anti-poverty policies implemented in 28 Chinese provinces.Design/methodology/approachThis study uses meta-frontier undesirable dynamic two-stage data envelopment analysis. The authors divide the poverty reduction process into two stages: agricultural production and poverty reduction. Public expenditure is the input for the second stage, and the population below the poverty line is the undesirable output. The authors compute the efficiencies (overall efficiency, efficiency of each stage and the efficiencies of individual inputs and outputs) using meta-frontier analysis for the 28 provinces.FindingsThe results show that: (1) a significant imbalance exists between the eastern and western regions in terms of input-output efficiencies; (2) the poverty reduction stage generally fared better than the agricultural production stage did. In particular, most provinces saw increases in poverty reduction efficiencies between 2013 and 2017; (3) the place-based poverty relief policies introduced in recent years are effective at reducing the poverty rate and reaching the government-set goals and (4) while disposable income has increased steadily over the past few years, income inequality has been exacerbated.Research limitations/implicationsThe results show that: (1) a significant imbalance exists between the eastern and western regions in terms of input-output efficiencies; (2) the poverty reduction stage generally fared better than the agricultural production stage did. In particular, most provinces saw increases in poverty reduction efficiencies between 2013 and 2017; (3) the place-based poverty relief policies introduced in recent years are effective at reducing the poverty rate and reaching the government-set goals and (4) while disposable income has increased steadily over the past few years, income inequality has exacerbated.Originality/valueA large amount of attention and public resources are devoted to fighting poverty and associated market failures in China. The extant literature focuses either on the agricultural production itself or the relationship between human capital and productivity levels. Making use of recent developments of the DEA method, the authors propose a new framework for evaluating the efficiencies of the poverty reduction process. Such a framework has the advantage of giving researchers and policymakers a more detailed diagnosis with regard to the components in the endeavor to eliminate poverty and providing useful information for policymakers to optimize public funds use. Methodologically, the framework is flexible enough to be employed for future research in similar appraisals, at different geographic and scale aggregation levels, for public projects including but not limited to poverty reduction.
A multi-objective grey wolf optimizer (GWO)-based multi-layer perceptrons (MLPs) trainer for optimal PMUs placement
Authors: Laouid Abdelkader Azzeddine , Mohrem Abdelkrim , Djalab Aicha 
Published: November 2021

Purpose
This paper aims to find the minimum possible number of phasor measurement units (PMUs) to achieve maximum and complete observability of the power system and improve the redundancy of measurements, in normal cases (with and without zero injection bus [ZIB]), and then in conditions of a single PMU failure and outage of a single line.

Design/methodology/approach
An efficient approach operates adequately and provides the optimal solutions for the PMUs placement problem. The finest function of optimal PMUs placement (OPP) should be mathematically devised as a problem, and via that, the aim of the OPP problem is to identify the buses of the power system to place the PMU devices to ensure full observability of the system. In this paper, the grey wolf optimizer (GWO) is used for training multi-layer perceptrons (MLPs), which is known as Grey Wolf Optimizer (GWO) based Neural Network (“GW-NN”) to place the PMUs in power grids optimally.

Findings
Following extensive simulation tests with MATLAB/Simulink, the results obtained for the placement of PMUs provide system measurements with less or at most the same number of PMUs, but with a greater degree of observability than other approaches.

Practical implications
The efficiency of the suggested method is tested on the IEEE 14-bus, 24-bus, New England 39-bus and Algerian 114-bus systems.

Originality/value
This paper proposes a new method for placing PMUs in the power grids as a multi-objective to reduce the cost and improve the observability of these grids in normal and faulty cases.
Arab scholars’ acceptance of informal scholarly communication tools: applying the technology acceptance model 2 (TAM2)
Authors: Alwreikat Asma , Shehata Ahmed Maher Khafaga , Abu Zaid Mohammed Khair 
Published: November 2021

PurposeThis paper aims to use the technology acceptance model 2 (TAM2) to investigate the perceived ease of use, perceived benefits, barriers to use and acceptance of Arab scholars of informal communication tools in research writing.Design/methodology/approachThis study adopted a quantitative approach using a questionnaire distributed among Arab scholars in Jordan, Egypt and Oman. The questionnaire based on the TAM2 model aimed to measure the acceptance of the sample of informal scholarly communication tools.FindingsThe study’s findings confirmed that the sample is considering informal scholarly communication tools are useful for their research. Informal scholarly communication tools increase the papers’ visibility, leading to a higher number of citations, building scholars’ reputation, creating new collaboration opportunities and maintaining the established collaboration.Research limitations/implicationsThe study’s findings can only be generalized on Arab scholars. The sample size could be one of the limitations, and the sample’s distribution was limited to three Arab universities in Jordan, Oman and Egypt. The authors recommend that future researchers use TAM2 model as a framework for studying the adoption of informal scholarly communication tools in different cultural contexts to achieve a better understanding of factors influencing the adoption of such tools.Practical implicationsA practical implication of this research is in drawing the attention of higher education institutions for the potentials of these scholarly communication tools in increasing the availability of publications of their scholars and increasing the citation of these publications, which would help in increasing the ranking of scholars, and the rank of these institutions which opens new opportunities of international research collaboration.Social implicationsThe outcomes of this research have several implications for the successful adoption of the TAM2 model. This study brings new knowledge to the literature related to informal scholarly communication adoption by the application of TAM2 constructs to determine the adoption behavior; the findings offered evidence of the TAM2 success in predicting adoption of such tools.Originality/valueTo the best of the authors’ knowledge, adopting TAM2 in this research will add to knowledge by being one of the first studies to adopt TAM2 to measure acceptance of informal scholarly communication tools.
An Islamic vision and approach for entrepreneurship: developing through a multi-stage comparative analysis of systems, ideologies and code of ethics
Authors: Javaid Omar 
Published: November 2021

Purpose
The purpose of this paper is to highlight the Islamic character of entrepreneurial activity along with its systemic, ideological and ethical particularities in contrast to the tech-based entrepreneurial model of Silicon Valley.

Design/methodology/approach
Hollingsworth’s framework of institutional analysis is used to analyze and compare the institutional design of tech-based entrepreneurship originated in Silicon Valley with the Islamic alternative.

Findings
An ideal Muslim entrepreneur will have a service-oriented-collectivist mindset, as opposed to an individualistic-self-centric mindset, where solving problems for all stakeholders is a priority instead of profit maximization at the expense of other stakeholders. A Muslim entrepreneur while ensuring the financial sustainability of the firm would avoid complexity on a systemic level, thus would adopt a personalized-family-like atmosphere. A Muslim entrepreneur will also constructively engage local stakeholders and will not possess a disintegrating tendency toward the local social structures.

Practical implications
The paper can help Muslim entrepreneurs to critically evaluate their entrepreneurial activities and firm design in contrast to the contemporary tech-based model.

Originality/value
A number of papers already have discussed the features of an Islamic model of entrepreneurship, however, none has done so while sequentially comparing the Islamic alternative with the contemporary model using Hollingsworth’s framework of institutional analysis. In this paper, the resulting model of Islamic entrepreneurship can be clearly evaluated and contrasted, feature by feature, with its tech-based counterpart.
Financial inclusion and legal system quality: are they correlated?
Authors: Ozili Peterson K. 
Published: November 2021

PurposeThis study investigates the correlation between financial inclusion and legal system quality.Design/methodology/approachPearson correlation analysis was used to assess the correlation between financial inclusion and legal system quality.FindingsThe author finds evidence for a positive correlation between financial inclusion and legal system quality. The findings suggest that improvements in legal system quality go hand in hand with improvements in the level of financial inclusion. More specifically, higher supply of ATM per 100,000 adults is correlated with stronger insolvency resolution framework among G7, European and non-European countries. Also, the number of bank branch per 100,000 adults is positively correlated with strong rule of law and legal rights in non-European countries. Also, the number of ATMs per 100,000 adults is positively correlated with strength of insolvency resolution framework and negatively correlated with the time it takes to resolve insolvency before, during and after the global financial crisis.Originality/valueNo study has explicitly analyzed the correlation between financial inclusion and legal system quality. This present study contributes to the literature by filling this research gap.
Getting acquainted with social networks and apps: talking about TikTok
Authors: Anderson Katie Elson 
Published: November 2021

Purpose
This paper aims to provide information and promote discussion around the social media platform TikTok.

Design/methodology/approach
Research, literature review.

Findings
Libraries and library and information professionals should be aware of the potential of TikTok for engagement and information sharing.

Originality/value
Adds to the research on the social media platform TikTok.
Incorporating customer profitability analysis into quality management systems
Authors: Sedevich-Fons Leonardo 
Published: November 2021

PurposeThe specific purpose of this article is to describe customer profitability analysis and evaluate its compatibility with quality management systems. Besides, its more general objective consists in shedding further light on the links between management accounting and quality management, which is still an emerging topic.Design/methodology/approachThe first part of the document presents a theoretical description of the disciplines and tools that are relevant to the study. Afterward, an explanation of the way in which customer profitability analysis is operationalized in practice is provided. Subsequently, a framework for the incorporation of customer profitability analysis into a quality management system is introduced. The final section includes some recommendations for future research.FindingsThrough the analysis of the benefits of the incorporation of customer profitability analysis into an ISO 9000 model, the study provides further support to the premise that the joint consideration of management accounting techniques and quality management tools is beneficial to organizations.Originality/valueThe article combines two disciplines closely related in practice but seldom concurrently addressed in the literature.
Effects of anti‐beta 2‐glycoprotein 1 antibodies and its association with pregnancy‐related morbidity in antiphospholipid syndrome
Authors: Fierro Juan J. , Velásquez Manuela , Cadavid Angela P. , de Leeuw Karina 
Published: November 2021

AbstractAntiphospholipid syndrome (APS) is an autoimmune disease characterized by venous, arterial, or small‐vessel thrombosis and/or pregnancy‐related morbidity, associated with persistent positivity of antiphospholipid antibodies (aPL). Pregnancy‐related morbidity in APS patients is characterized by unexplained fetal deaths, premature birth of morphologically normal newborns, and/or consecutive pregnancy losses before the 10thweek of gestation. Beta 2‐glycoprotein 1 (ß2GP1) is the main antigen recognized by aPL and plays an essential role in the pathogenesis of APS. Antibodies against ß2GP1 (aß2GP1) are involved in damage‐generating mechanisms in APS due to their interaction with trophoblasts, decidua, and endothelial cells. aß2GP1 might be used as a prognostic tool for obstetric risk stratification and ß2GP1 could be a target for molecular‐targeted treatment to prevent pregnancy morbidity in APS. This review describes these aspects of aß2GP1, including effects on different cellular targets, its association with the severity of obstetric manifestations and the potential of ß2GP1‐targeted therapies for APS.
Uncomplicated oocyte donation pregnancies display an elevated CD163‐positive type 2 macrophage load in the decidua, which is associated with fetal‐maternal HLA mismatches
Authors: Tian Xuezi , Aiyer Kaveri T. S. , Kapsenberg Johanna M. , Roelen Dave L. , van der Hoorn Marie‐Louise , Eikmans Michael 
Published: November 2021

AbstractProblemThe embryo of an oocyte donation (OD) pregnancy is completely allogeneic to the mother, which may challenge the maternal immune system to tolerize the fetus. Decidual macrophages are essential in maintaining a healthy pregnancy, and type 2 macrophages may exhibit immune suppressive activity. We hypothesized that the composition of decidual macrophages is different between uncomplicated OD pregnancies and non‐OD in vitro fertilization (IVF) pregnancies, and is related to fetal‐maternal incompatibility.Method of studyWomen with uncomplicated pregnancy were enrolled: 25 singleton OD pregnancies and 17 non‐OD IVF pregnancies. The extent of immunohistochemical staining of CD14 (pan‐macrophage marker) and CD163 (type 2 macrophage marker) in both decidua basalis and parietalis was quantitated by digital image analysis. Maternal and fetal DNA was typed for human leukocyte antigen (HLA)‐A, ‐B, C, ‐DRB1, and ‐DQB1, and fetal‐maternal HLA mismatches were calculated.ResultsOD pregnancies showed a higher percentage of CD163+ staining (P = .040) and higher CD163/CD14 ratio (P = .032) in the parietalis than non‐OD IVF. The OD group was separated into a semi‐allogeneic group (≤5 fetal maternal HLA mismatches) and a fully allogeneic group (> 5 mismatches). The HLA‐fully‐allogeneic OD group, but not the HLA‐semi‐allogeneic OD group, showed significantly elevated CD163/CD14 ratio in the parietalis compared with the non‐OD IVF group (P < .05).ConclusionsUncomplicated OD pregnancies display a higher CD163‐positive cell fraction in the total decidual macrophage population compared to autologous pregnancies, which may suggest that a local type 2 macrophage‐related mechanism is needed to compensate for the higher fetal‐maternal HLA mismatch load.
Impaired skin barrier and allergic sensitization in early infancy
Authors: Wärnberg Gerdin Sabina , Lie Anine , Asarnoj Anna , Borres Magnus P. , Lødrup Carlsen Karin C. , Färdig Martin , Konradsen Jon R. , Monceyron Jonassen Christine , Olsson Mägi Caroline‐Aleksi , Rehbinder Eva Maria , Rudi Knut , Skjerven Håvard Ove , Staff Anne Cathrine , Söderhäll Cilla , Tedner Sandra G. , van Hage Marianne , Vettukattil Riyas , Nordlund Björn 
Published: November 2021

AbstractBackgroundFactors predicting allergic sensitization in the first 6 months of life are poorly understood. We aimed to determine whether eczema, dry skin, and high transepidermal water loss (TEWL) at 3 months were associated with allergic sensitization at 6 months of age and, secondarily, to establish whether these characteristics predicted sensitization from 3 to 6 months of age.MethodsAt 3 months of age, 1,994 infants from the population‐based PreventADALL birth cohort in Norway and Sweden were assessed for eczema and dry skin on the cheeks and/or extensors; impaired skin barrier function, defined as TEWL in the upper quartile (>9.4 g/m2/h), and allergen‐specific IgE levels <0.1 kUA/L, available in 830. At 6 months, we assessed allergic sensitization to any food (egg, cow's milk, peanut, wheat, soy) or inhalant (birch, timothy grass, dog, and cat) allergen by a skin prick test wheal diameter ≥2 mm larger than negative control.ResultsAny sensitization was found in 198 of the 1,994 infants (9.9%), the majority to food allergens (n = 177, 8.9%). Eczema, dry skin, and high TEWL at 3 months increased the risk of sensitization at 6 months; adjusted odds ratios 4.20 (95% CI 2.93–6.04), 2.09 (95% CI 1.51–2.90) and 3.67 (95% CI 2.58–5.22), respectively. Eczema predicted sensitization with 55.6% sensitivity and 68.1% specificity; dry skin with 65.3% sensitivity and 57.3% specificity; and high TEWL with 61.7% sensitivity and 78.1% specificity.ConclusionEczema, dry skin, and high TEWL at 3 months predicted allergic sensitization at 6 months of age.
Human factors in ECLS – A keystone for safety and quality – A narrative review for ECLS providers
Authors: Swol Justyna , Brodie Daniel , Willers Anne , Zakhary Bishoy , Belezzo Joseph , Shinar Zachary , Weingart Scott D. , Haft Jonathan W. , Lorusso Roberto , Peek Giles J. 
Published: November 2021

AbstractIntroductionAlthough the technology used for extracorporeal life support (ECLS) has improved greatly in recent years, the application of these devices to the patient is quite complex and requires extensive training of team members both individually and together. Human factors is an area that addresses the activities, contexts, environments, and tools which interact with human behavior in determining overall system performance.HypothesisAnalyses of the cognitive behavior of ECLS teams and individual members of these teams with respect to the occurrence of human errors may identify additional opportunities to enhance safety in delivery of ECLS.ResultsThe aim of this article is to support health‐care practitioners who perform ECLS, or who are starting an ECLS program, by establishing standards for the safe and efficient use of ECLS with a focus on human factor issues. Other key concepts include the importance of ECLS team leadership and management, as well as controlling the environment and the system to optimize patient care.ConclusionExpertise from other industries is extrapolated to improve patient safety through the application of simulation training to reduce error propagation and improve outcomes.
New‐onset celiac disease in children during COVID‐19 pandemic
Authors: Cakir Murat , Guven Burcu , Issi Fatma , Ozkaya Esra 
Published: November 2021

AbstractAimWe aimed to analyse the influence of the COVID‐19 pandemic on the frequency and clinical presentation of celiac disease.MethodsThe study included the patients with celiac disease since January 2008. They were divided into 2 groups (diagnosed in pre‐pandemic [January 2008 and February 2020] [n = 148] and in pandemic period [March 2020 and June 2021] [n = 47]). Clinical and histological findings were compared between groups. Additionally, data about severe acute respiratory syndrome coronavirus 2 infection were obtained in subgroup patients (n = 22) with celiac disease diagnosed during pandemic period.ResultsThe number of patients per year (12.1–37.6) and the percentage of patients who were diagnosed with celiac disease/total endoscopy were increased during the pandemic period (2.2% vs. 10%, p < 0.00001). The association of celiac disease with type 1 diabetes mellitus was significantly high in pandemic period (4% vs. 17%, p = 0.002). Frequency of moderate‐severe mucosal lesions was low in pandemic period (42.4% vs. 81.7%, p = 0.0001). Clinical and laboratory markers for the past severe acute respiratory syndrome coronavirus 2 infection were found in 36.3% of patients diagnosed during the pandemic period.ConclusionIt seems that the frequency of celiac disease and its association with type 1 diabetes mellitus is increased during the COVID‐19 pandemic in children.