bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Japan nationwide web‐based survey of estimation on patients for renal denervation based on blood pressure level and the number of antihypertensives (J‐NEEDs survey)
Authors: Kagitani Hideaki , Hayashi Shoko , Hanamura Satsuki , Ozawa Keisuke , Kobayashi Daisuke , Hiki Shunsuke , Kario Kazuomi 
Published: August 2021

AbstractCatheter‐based renal denervation (RDN) is currently being developed as a new complementary treatment option for hypertension. RDN has not yet received approval in Japan and so the number of possible candidates for RDN in Japan also remains unknown. A total of 10 756 hypertensive patients who regularly visit medical institutions and reported their latest home blood pressure (BP) values were identified from registrants at an online research company. They filled out a survey regarding their prescribed antihypertensives and latest BP values in March 2020 in Japan. The mean age of the patients was 61.3 years old (83.5% male). According to JSH 2019, the prevalence of resistant hypertension (RHT) was estimated to be 1.4% (0.52% having an office BP of 140/90 mm Hg or more while taking three antihypertensives, including diuretics; 0.84% taking four or more antihypertensives regardless of BP level). Assuming the indication for RDN was RHT with morning home systolic BP (HSBP) ≥ 135 mm Hg and office systolic BP (OSBP) ≥ 140 mm Hg, the number of candidates for RDN was estimated to be approximately 340 000 and 372 000, respectively. When hypertensive patients prescribed three or more, two, one, and no antihypertensives were included, the estimated number based on uncontrolled HSBP and OSBP cumulatively increased 2.6, 14.2, 40.6, and 58.0‐fold; 1.8, 8.6, 25.3, and 36.4‐fold, respectively. These findings revealed that a substantial number of hypertensive patients are unable to adequately control their BP level with existing treatments, and new complemental therapies, such as RDN, would alleviate the burden of hypertension in this population.
MicroRNA‐205‐5p targets E2F1 to promote autophagy and inhibit pulmonary fibrosis in silicosis through impairing SKP2‐mediated Beclin1 ubiquitination
Authors: Qian Qingzeng , Ma Qinghua , Wang Bin , Qian Qingqiang , Zhao Changsong , Feng Fumin , Dong Xiaona 
Published: August 2021

AbstractSilicosis is an occupational disease characterized by extensive pulmonary fibrosis, and the underlying pathological process remains uncertain. Herein, we explored the molecular mechanism by which microRNA‐205‐5p (miR‐205‐5p) affects the autophagy of alveolar macrophages (AMs) and pulmonary fibrosis in mice with silicosis through the E2F transcription factor 1 (E2F1)/S‐phase kinase‐associated protein 2 (SKP2)/Beclin1 axis. Alveolar macrophages (MH‐S cells) were exposed to crystalline silica (CS) to develop an in vitro model, and mice were treated with CS to establish an in vivo model. Decreased Beclin1 and increased SKP2 and E2F1 were identified in mice with silicosis. We silenced or overexpressed miR‐205‐5p, E2F1, SKP2 and Beclin1 to investigate their potential roles in pulmonary fibrosis in vivo and autophagy in vitro. Recombinant adenovirus mRFP‐GFP‐LC3 was transduced into the MH‐S cells to assay autophagic flow. Knocking down Beclin1 promoted pulmonary fibrosis and suppressed the autophagy. Co‐immunoprecipitation and ubiquitination assays suggested that SKP2 induced K48‐linked ubiquitination of Beclin1. Furthermore, chromatin immunoprecipitation‐PCR revealed the site where E2F1 bound to the SKP2 promoter between 1638 bp and 1645 bp. As shown by dual‐luciferase reporter gene assay, the transfection with miR‐205‐5p mimic inhibited the luciferase activity of the wild‐type E2F1 3′untranslated region, suggesting that miR‐205‐5p targeted E2F1. Additionally, miR‐205‐5p overexpression increased autophagy and reduced the pulmonary fibrosis, while overexpression of E2F1 or SKP2 or inhibition of Beclin1 could annul this effect. The current study elucidated that miR‐205‐5p targeted E2F1, thereby inhibiting SKP2‐mediated Beclin1 ubiquitination to promote macrophage autophagy and inhibit pulmonary fibrosis in mice with silicosis.
Religious differences and households' investment decisions
Authors: Kim Hohyun , Kim Kyoung T. , Han Seung H. 
Published: August 2021

AbstractThis study examines effects of religion on US households' investment decisions, with focusing on the two channels; individual religious belief and local religious culture. We find that Protestants are less likely to invest in stocks than nonreligious households. Catholics are more likely to participate in stock markets than nonreligious households, which is largely driven by Catholic households' greater wealth and older age. Moreover, a higher local Catholic–Protestant ratio (CPratio) is associated with greater stock market participation of the local households, regardless of their own religious preferences. Furthermore, we find that the local CPratio is associated with stock choices—the higher the CPratio, the riskier the stock portfolios. The findings are economically meaningful and they provide salient insights into theory and policy.
Temporal changes in magnetic resonance imaging appearance of adult granulosa cell tumor
Authors: Ueda Masashi , Sato Yukiyasu , Iwami Shuichiro , Dodo Toshiki , Shirase Tomoyuki , Fujita Kohei 
Published: August 2021

AbstractGranulosa cell tumors (GCTs) can have a wide variety of appearances on magnetic resonance imaging (MRI), ranging from entirely solid to multilocular cystic, suggesting that GCTs undergo remarkable morphological changes during growth. These temporal changes in MRI appearance of individual GCTs have not been documented. A 54‐year‐old asymptomatic postmenopausal woman was referred to our department for a small ovarian mass. This 3‐cm solid mass showed high intensity on diffusion‐weighted MRI and low intensity on apparent diffusion coefficient mapping. Close clinical follow‐up was recommended, but she did not return to our hospital until the age of 63, when she was referred for a large ovarian tumor. MRI showed a 15‐cm multilocular cyst containing a solid component with hemorrhaging. Postoperative diagnosis was adult GCT (AGCT). These temporal changes demonstrate a possible reason why GCTs can have such a wide range of MRI appearance. This knowledge might promote accurate preoperative diagnosis of AGCTs.
Incarceration and family instability: Considering relationship churning
Authors: Turney Kristin , Halpern‐Meekin Sarah 
Published: August 2021

AbstractObjectiveThis study examines the association between incarceration and relationship churning.BackgroundIt is well known that incarceration gives rise to family instability, in the form of relationship dissolution and impaired relationship quality. However, existing research does not consider the repercussions of incarceration for a common, yet understudied, form of family instability—relationship churning (being in an on‐again/off‐again relationship)—despite good reasons to expect that incarceration may destabilize relationships in this way.MethodThis study used data from the Fragile Families and Child Wellbeing Study (N = 4060) to examine the association between incarceration and relationship churning.ResultsThis study finds that incarceration was positively associated with relationship churning, net of characteristics associated with selection into incarceration. These associations were concentrated among Black parents and those experiencing incarceration for the first time. Supplemental analyses show that both maternal incarceration and paternal incarceration were similarly associated with subsequent relationship churning.ConclusionTaken together, the findings suggest the liminal status induced by incarceration may facilitate liminality in family relationships.
Compact development and preferences for social mixing in location choices: Results from revealed preferences in Santiago, Chile
Authors: Cox Tomás , Hurtubia Ricardo 
Published: August 2021

AbstractEven though densification and social mixing are declared objectives of many nowadays urban planning paradigms, their simultaneous implementation is usually questioned by different actors and is not frequent in practice. In a market economy, understanding potential demand for this class of development, from different types of households, is essential to define public policies oriented to achieve both compact development (CD) and social mixture. To understand the preferences of households and potential demand, we implement a location choice model based on a bid–rent framework and spatial latent classes (LC), using census data and location attributes. By using spatial LC, we do not impose exogenous definitions of which zones are perceived as CD or suburban, rendering a robust method to identify variation in preferences. We apply the model to Santiago de Chile, where social mixing in dense and well‐located areas is being intensely discussed. We find strong differences in households' valuation of attributes between spatial classes. Results show that social mixing is more difficult in dense, well‐connected areas than in suburban areas because higher‐income households are more sensitive to the socioeconomic context of the location in compact areas. Besides showing evidence on household preferences and their implications for social‐mixing policies, this paper also provides a proof of concept for the use of spatial LC (proposed in previous work by the authors), showing this is a robust methodology allowing to generate behavior‐based classifications for urban areas. The paper also contributes methodologically, by deriving the elasticity formulation for bid‐auction location choice models, which allows quantifying the importance of location attributes in location probability.
Reducing Educators' Weight Bias: The Role of School‐Based Anti‐Bullying Policies
Authors: Lessard Leah M. , Puhl Rebecca M. 
Published: August 2021

ABSTRACTBACKGROUNDEducators' negative weight biases toward students with high body weight have been well‐documented. The present investigation examined whether inclusion of body weight in school anti‐bullying policies is associated with lower levels of weight bias among educators.METHODSData on explicit weight bias was collected from a sample of secondary school teachers and principals in the United States (N = 246) and examined in relation to the presence of weight‐related language in each participant's school district anti‐bullying policy.RESULTSThe results indicate that, although educators on average make negative judgments about individuals with high weight, these biases were lower for educators whose school district anti‐bullying policy included enumeration of body weight. Notably, this association did not hold when policies enumerated “appearance.”CONCLUSIONSThe study findings suggest that the explicit mention of “weight” in school anti‐bullying policies may represent a feasible mechanism to reduce explicit weight bias among U.S. secondary school educators.
School Safety Among Sexual and Gender Minority Adolescents: Implications for Eating and Weight Control Behaviors
Authors: Lessard Leah M. , Wang Ethan Y. , Watson Ryan J. 
Published: August 2021

ABSTRACTBACKGROUNDUnhealthy weight control and disordered eating behaviors are prevalent among adolescents who identify as a gender and/or sexual minority (SGM). The current study examined how perceptions of school safety contribute to reduced negative weight control and eating behaviors across adolescents with diverse sexual and gender identities.METHODSData on perceptions of school safety, as well as negative weight control and disordered eating behaviors (ie, binge eating, eating to cope), were drawn from a large national sample of SGM secondary school students (ie, grades 7‐12; N = 17,112; LGBTQ National Teen Survey).RESULTSDifferences in negative weight control and disordered eating behaviors emerged as a function of gender identity and sexual orientation. School safety was significantly associated with fewer negative weight control behaviors (B = −0.30, p < .001), reduced binge eating (B = −0.19, p < .001), and less eating to cope (B = −0.21, p < .001). Despite slight variation in the strength of these associations, the protective effects of school safety were significant across sexual and gender identities.CONCLUSIONSFindings suggest that efforts to support feelings of school safety among SGM students are likely to have positive implications for eating and weight‐related behaviors, and emphasize the need for interventions to promote climates of safety and inclusion within the school setting.
Development and Reach of the Stanford Tobacco Prevention Toolkit: Implementation of a Community‐Based Participatory Approach
Authors: Gaiha Shivani Mathur , Zorrilla Marcia , Sachnoff Ira , Smuin Stephen , Lazaro Adrienne , Ceballos Richard Daniel , Razo Anabel , Halpern‐Felsher Bonnie 
Published: August 2021

ABSTRACTBACKGROUNDWe developed the Tobacco Prevention Toolkit (Toolkit) to enhance the impact of school‐based tobacco education. This study describes the process of developing the Toolkit, its contents, and reach.METHODSQualitative community‐based participatory research (CBPR), including focus group discussions (N = 152) and working groups with parents, educators, researchers, and youth (N = 87) were used to develop the Toolkit and design its implementation. Toolkit reach was assessed through number of trained educators using the Toolkit, estimated number of youth recipients of the Toolkit resources, and using Google Analytics for online engagement.RESULTSThe Toolkit is a free, online resource aimed at preventing tobacco use by middle and high school students. Toolkit content addresses varied forms of tobacco including electronic cigarettes, hookah, smokeless tobacco, and cigarettes; addiction; and positive youth development; and is available in multiple interactive formats such as real‐time quizzes, factsheets, activities, and presentations. The Toolkit is mainly delivered by trained educators, who adapt its content and duration to tailor their drug prevention teaching to student needs. As of April 2020, when data for this paper were collected, 4,750 educators have reached an estimated 1.3 million youth. The Toolkit website has 186,116 users and 802,602 page views, growing steadily since 2016. As of August 2021, additional students have been reached, for now a total of 1.85 million students reached.CONCLUSIONThe Toolkit resources are evidence‐based, comprehensive, responsive, interactive, easily accessible, and flexible. Applying CBPR was instrumental in developing the Toolkit and expanding its reach.
Prevalence and Impact of Adverse Childhood Experiences on Chicago Public School Students in the Youth Risk Behavior Survey
Authors: Korpics Jacqueline , Altman Lara , Feinglass Joseph , Stillerman Audrey 
Published: August 2021

ABSTRACTBACKGROUNDAdverse Childhood Experiences (ACEs) can impair health and other outcomes. To obtain district‐level data about the prevalence and impact of ACEs in Chicago Public Schools (CPS), we advocated for CPS to add a short ACE screener to the 2017 Youth Risk Behavior Survey (YRBS) and analyzed the results.METHODSResponses to the screener were scored zero, one, or two ACEs. Student scores for violence and victimization, substance use, sexual health risk, mental health, housing insecurity, physical health, grades, and multiple risk/high vulnerability (those students in the top 20% of affirmative responses) were correlated with ACE scores for categories and individual items.RESULTSAmong 1883 student respondents (response rate 73%), there were 17.8% affirmative responses for experiencing physical abuse and 19.8% for witnessing domestic violence; 20% reported at least one ACE and 8% both. A significant dose‐response was found for behaviors, experiences, and sleep by ACE scores.CONCLUSIONSACEs were common among CPS high school students and associated with many negative behavior and health‐related outcomes. Increased awareness of ACEs and their impact among all school personnel can inform and strengthen the development of safer, more supportive, and trauma‐informed schools that help all students and families thrive.
Mosquito species associated with horses in Madagascar: a review of their vector status with regard to the epidemiology of West Nile fever
Authors: Tantely M. L. , Guis H. , Randriananjantenaina I. , Raharinirina M. R. , Velonirina H. J. , Cardinale E. , Raveloarijaona N. , Cêtre‐Sossah C. , Garros C. , Girod R. 
Published: August 2021

AbstractIn Madagascar, the high West Nile virus (WNV) antibody prevalence reported in horse populations suggests a high level of vector‐horse contact. This study aims to characterize the mosquito species usually involved in WNV transmission in horse stables in Madagascar. Five horse stables were investigated in October and November 2016 in five distinct inland areas. Mosquitoes were collected using double net traps baited with human, poultry or horse as well as light traps. Blood meal identification from engorged females was performed using host‐specific PCRs. A total of 2898 adult mosquitoes were collected with Culex (Culex) antennatus (Becker) (40.7%), and Cx. (Cux.) quinquefasciatus Say (14.9%), being the most abundant species. The mosquito abundance varied between horse stables (P < 10−7) and depending on the bait used in the double net traps (P < 0.003). Among the 190 tested blood meals, 119 consisted of single blood meals with 85 from horse, 17 from human, 16 from chicken, one from cattle and 71 consisted of mixed blood meals. The mosquito species collected during this study exhibited a generalist feeding behaviour allowing them to act as bridge vectors between different vertebrate hosts involved in WNV transmission cycle. Their vector status with regard to West Nile fever epidemiology is reviewed.
A genealogy of what nurses know about ‘the good death’: A socio‐materialist perspective
Authors: Rushton Carole , Edvardsson David 
Published: August 2021

AbstractIn this article, we report the outcome of a sociological inquiry into nursing knowledge of death and dying, specifically ‘the good death’. A genealogical approach informed by actor‐network theory and appreciative inquiry were used to compose a broad socio‐material account of how nurses concern themselves with the care of the dying and end‐of‐life care. Our enquiry revealed similarly to other studies, that there was no shared or overarching model of care. Key themes derived from nurses' translations of ‘the good death’ were re‐presented pictorially as six pillars and two processes to comprise a new diagram of The Personalised Ideal Death.
Drought response QTLs in a Super Basmati × Azucena population by high‐density GBS‐based SNP linkage mapping
Authors: Waheed Raheela , Ignacio John Carlos , Arbelaez Juan David , Juanillas Venice Margarette , Asif Muhammad , Henry Amelia , Kretzschmar Tobias , Arif Muhammad 
Published: August 2021

AbstractBasmati rice is favoured for its grain type and aroma, but its production is vulnerable due to climate change and freshwater accessibility. Discovery and refinement of genomic regions conferring drought tolerance are needed to develop new drought tolerant Basmati varieties. Using Recombinant Inbred Lines (RILs) derived from a cross between drought‐sensitive elite Basmati variety, ‘Super Basmati’, and drought‐tolerant japonica cultivar, ‘Azucena’, a linkage map was constructed with 862 high‐quality GBS‐based SNP markers. Thirty‐three QTLs were detected for yield‐related and physiological traits. Of five QTL clusters, two were identified as novel on chromosome 7 and 11 for shoot dry weight and water uptake that could be designated as promising QTLs, and their candidate gene analysis suggested contributions to yield in the ‘Super Basmati’ background. Comparing the greenhouse and field results, this study suggests that selection of drought tolerance donor varieties must be matched with the target growth stage of drought tolerance needed. Along with fine mapping and functional marker selection, the QTL clusters identified can be further tested to contribute to Basmati rice improvement.
The Immigration Rhetoric of Donald Trump
Authors: Eshbaugh‐Soha Matthew , Barnes Kenlea 
Published: August 2021

Abstract
Donald Trump's rise to the presidency included frequent and divisive public remarks on immigration. He not only promised to secure the border by building a wall, but he also assured his supporters that Mexico would pay for it! Nevertheless, we know little about how frequently and in what ways President Trump spoke about immigration. Moreover, was Donald Trump's rhetoric mere bluster, or did it affect Congress and the public in measurable ways? To answer these questions, we collected all public comments by President Trump related to immigration. We describe both Trump's level of attention to immigration policy and its tone, and compare this with legislative activity and public opinion on immigration. We find that although Trump devoted considerable public attention to immigration through a slightly positive lens, he was more bluster than substance in leading Congress and public opinion on immigration.
Skeletal muscle phenotype and game performance in elite women football players
Authors: Mohr Magni , Fatouros Ioannis G. , Jamurtas Athanasios Z. , Draganidis Dimitrios , Thomassen Martin , Ørntoft Christina , Ermidis Georgios , Loules Georgios , Batsilas Dimitrios , Poulios Athanasios , Papanikolaou Konstantinos , Randers Morten B. , Krustrup Peter , Nybo Lars 
Published: August 2021

We combined game activity analyses with skeletal muscle phenotypes and comprehensive physiological testing to elucidate factors of importance for physical performance in elite women's football. GPS‐data from an experimental game, sprint and endurance testing, and muscle tissue analysis of metabolic enzyme activity, protein expression and fiber type composition were completed for international top‐level women players (n = 20; age; 23 ± 4 yrs, height; 166 ± 10 cm, weight; 60 ± 8 kg; VO2max; 51 ± 6 ml/min/kg). Muscle monocarboxylate transporter 4 (MCT4) protein expression explained 46% of the variance in total game distance, while the ability to maintain high‐intensity running (HIR) during the final 15 min of the game correlated to myosin heavy chain 1 (MHCI) and Na+‐K+ ATPase β1, FXYD1 (phospholemman) and superoxide dismutase 2 (SOD2) protein expression (range: r = 0.51–0.71; all p < 0.05). Total HIR distance correlated with (MHCIIa) protein expression (r = 0.51; p < 0.05), while muscle Na+/H+ exchanger 1 (NHE1) protein explained 36% of the variance in game sprint distance (p < 0.05). Total game accelerations (actions >4 m/s2) correlated with platelet endothelial cell adhesion molecule (PECAM‐1) protein expression (r = 0.51; p < 0.05), while concentric knee flexor strength explained 42–62% of the variance in intense decelerations (>4 m/s2). In conclusion, for elite women players’ game endurance performance and resistance to end‐game fatigue were affected by monocarboxylate transporter expression and myosin heavy chain profile. HIR was also correlated to ion transporter expression and muscle antioxidative capacity. Finally, the importance of functional strength and measures of muscle vascularization in relation to total game decelerations and accelerations, respectively, illustrates the complex physiological demands in elite women's football.