bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD38 expression is an important prognostic marker in diffuse large B‐cell lymphoma
Authors: Wada Fumiya , Shimomura Yoshimitsu , Yabushita Tomohiro , Yamashita Daisuke , Ohno Aya , Imoto Hiroharu , Maruoka Hayato , Hara Shigeo , Ishikawa Takayuki 
Published: July 2021

AbstractDiffuse large B‐cell lymphoma (DLBCL) is a heterogeneous group of diseases with variable outcomes. Although several prognostic markers have been developed, specific biomarkers for stratifying treatment strategies have not been fully investigated. This study aimed to analyze the clinical impact of the expression of cluster of differentiation (CD) 38, which is associated with cellular proliferation and disease progression, in patients with de‐novo DLBCL. Using flow cytometry analysis, 137 cases with DLBCL were investigated for surface expression of CD38. Based on the cut‐off value by the survival classification and regression tree analysis, the patients were categorized into a CD38HIGH group (n = 37) and CD38LOW group (n = 100). The 4‐years progression‐free survival (PFS) was 31.6% in the CD38HIGH group and 60.7% in the CD38LOW group (p < 0.001). Multivariate analysis showed the CD38HIGH group to be associated with significantly worse PFS (adjusted hazard ratio [aHR], 2.15, 95% CI: 1.26–3.68, p = 0.005) and poor overall survival (OS) (aHR, 2.54, 95% CI: 1.25–5.19, p = 0.010) than the CD38LOW group. In conclusion, we demonstrated that high CD38 expression is an independent adverse prognostic factor associated with poor clinical outcomes compared to low CD38 expression. CD38 expression in DLBCL cells might be useful for predicting outcomes and designing risk‐adapted therapies for patients with de‐novo DLBCL.
The feasibility of the flower stenting technique for ostial lesions of the common iliac artery
Authors: Kishida Toshihiko , Hirano Keisuke , Mori Shinsuke , Yamawaki Masahiro , Kobayashi Norihiro , Tsutsumi Masakazu , Honda Yohsuke , Makino Kenji , Shirai Shigemitsu , Ito Yoshiaki 
Published: July 2021

AbstractBackground and AimsA balloon‐expandable stent (BES) is generally used for ostial lesions of the common iliac artery (CIA) owing to the positional ease of stent adjustment. However, there are potential risks such as vessel dissection and perforation due to vessel overstretching during. In our hospital, we performed endovascular therapy (EVT) for CIA ostial lesions via a novel method named “the flower stenting method,” using a self‐expandable stent. This study aimed to analyze the efficacy and safety of this method.MethodsThis study was single‐center, retrospective, and observational. We enrolled 83 patients (91 limbs) who underwent EVT with SMART stent (Cordis, Miami, Florida) for CIA ostial lesions from 2007 to 2014. The primary endpoint was the rate of freedom from target lesion revascularization (TLR) in 5 years, and the secondary endpoint was the success rate of stent placement for the CIA ostium.ResultsThe average patient age was 72.3 ± 9.4 years, 71% of the patients were men, 19% were receiving hemodialysis, and 60% had diabetes. Additionally, 38% of the lesions were Trans‐Atlantic Inter‐Society Consensus C/D lesions, while 37% were chronic total occlusion lesions. The average lesion length was 36 ± 23 mm, and the average vessel diameter was 10.7 ± 1.4 mm. The rate of freedom from TLR was 97.3% at 5 years, and the success rate of only stent placement was 90.1%.ConclusionThe flower stenting method leads to acceptable outcomes and is useful for accurate stent deployment.
Gestational diabetes is associated with postpartum hemorrhage in Indigenous Australian women in the PANDORA study: A prospective cohort
Authors: Lucas Isabelle M. , Barr Elizabeth L. M. , Barzi Federica , Longmore Danielle K. , Lee I‐Lynn , Kirkwood Marie , Whitbread Cherie , Connors Christine , Boyle Jacqueline A. , Simon David , Goodrem Adeliesje , Brown Alex D. H. , Oats Jeremy , McIntyre Harold D. , Shaw Jonathan E. , Maple‐Brown Louise ,   the PANDORA study research team
Published: July 2021

AbstractObjectiveTo assess associations of hyperglycemia in pregnancy with the risk of postpartum hemorrhage (PPH) in a prospective cohort of Indigenous and non‐Indigenous women, compared with normoglycemia.MethodsData were from 1102 (48% Indigenous) women of the Pregnancy And Neonatal Diabetes Outcomes in Remote Australia (PANDORA) Study. Age‐adjusted associations of gestational diabetes mellitus (GDM) or pre‐existing type 2 diabetes mellitus (T2DM), obstetric and demographic covariables with PPH (blood loss ≥500 ml) were assessed using logistic regression. Multivariable‐adjusted models included Indigenous ethnicity, diabetes type and their interaction.ResultsA higher proportion of Indigenous women developed PPH than non‐Indigenous women (32% versus 22%;P < 0.001). Compared with non‐Indigenous women with normoglycemia, risks of PPH for Indigenous women with GDM or T2DM were higher (odds ratio [OR] 1.83, 95% confidence intervals [CI] 1.11–3.02, and OR 1.72, 95% CI 0.99–3.00 after age adjustment, OR 1.84, 95% CI 1.06–3.19, and OR 1.33, 95% CI 0.70–2.54 after adjustment for school education and delivery mode, and OR 1.62, 95% CI 0.95–2.77, and OR 0.99, 95% CI 0.53–1.86 after adjustment for birth weight). Importantly, Indigenous women without hyperglycemia in pregnancy were not at increased risk of PPH.ConclusionThe significantly higher rates of PPH experienced by Indigenous women compared with non‐Indigenous women may be explained by a greater effect of GDM among Indigenous women that was only partly accounted for by birth weight.
Satisfaction of Quechua‐speaking indigenous pregnant women from a rural community in Peru with telemonitoring during the COVID‐19 pandemic
Authors: De La Cruz‐Ramirez Yuliana M. , Olaza‐Maguiña Augusto F. 
Published: July 2021

SynopsisAlthough the majority of Quechua‐speaking indigenous pregnant women are satisfied with telemonitoring during the COVID‐19 pandemic, there are still aspects to improve.
Impact of a small hydropower plant on water quality dynamics in a diversion and natural river channel
Authors: Tomczyk Paweł , Wiatkowski Mirosław 
Published: July 2021

AbstractThis study innovatively evaluates the impact of hydropower plants located in a diversion channel on water quality dynamics. The spatial characteristics of water in the diversion channel above and below a hydropower plant were assessed; specifically, the investigation was conducted in the watercourse undeveloped by the hydropower plant and at reference points. Among the five analyzed points, the strongest statistically significant changes were observed in electrical conductivity, pH, and dissolved oxygen. Statistical analyses showed a similar, statistically significant relationship for most months. The water quality indicators proposed in this study help assess hydropower plants’ impact on water quality dynamics because they enable water comparison at different locations. The best water quality, as calculated using designated indices, was recorded below the hydropower plant. Among the physicochemical parameter values, the most noticeable change occurred in dissolved oxygen below the hydropower plant and below the fixed weir; its value was 8.10 and 5.32% higher in the two locations at the reference point below the hydropower facility. Moreover, the NH4‐N content was higher by 7.06% below the weir than the point below the hydropower plant. In the long term, this research may help plant operators manage water resources on watercourses with hydropower development more efficiently, according to sustainable development principles. This research will contribute to the rational management of such facilities on diversion channels considering sustainable water management principles.
Fecal microbiota transplantation augmented by a sulfide‐reducing diet for refractory ulcerative colitis: A case report with functional metagenomic analysis
Authors: Bryant Robert V , Day Alice S , McGrath Ken C , Telfer Karmen , Yao Chu K , Costello Samuel P 
Published: July 2021

AbstractFecal microbiota transplantation (FMT) is effective for induction of remission in ulcerative colitis (UC). Diet has potential to augment the efficacy and durability of FMT by encouraging engraftment of transplanted microorganisms. A trial of FMT combined with a defined diet was undertaken as salvage therapy for a 71‐year‐old woman with active steroid‐refractory extensive UC. A multidimensional sulfide‐reducing diet (4‐SURE diet) was commenced followed by single‐donor FMT administered by colonoscopy and then enemas over 7 days. Dietary adherence, clinical evaluation, and stool samples for metagenomic profiling were undertaken at weeks 0, 4, 8, and 24. Colonoscopy was performed 8 weeks post‐FMT. Shotgun metagenomic profiling of the donor fecal suspension was also performed. A rapid clinical response to FMT and 4‐SURE diet was observed with normalization of stool frequency (≤2 motions/day) and resolution of rectal bleeding within 2 weeks. Dietary adherence was excellent. Colonoscopy at week 8 revealed no evidence of active colitis (Mayo endoscopic sub‐score 0) with histology showing no evidence of acute or chronic lamina propria inflammatory cell infiltrate. Sustained clinical and endoscopic remission out to 24 weeks was observed. Metagenomic sequencing confirmed sustained engraftment of beneficial donor microbiota with increased alpha‐diversity and capacity for short‐chain fatty acid production, including Faecalibacterium prauznitzii and Eubacterium hallii. This case report supports the rationale of prescribed diet therapy to support engraftment of donor microbiota following FMT for UC. Further large trials with a diet‐arm control group are needed to evaluate FMT augmented by a defined diet in UC.
Safety, feasibility, and comfort of hepatic angiography and transarterial intervention with radial access for hepatocellular carcinoma
Authors: Toyoda Hidenori , Yasuda Satoshi , Shiota Shohei , Chatani Shohei , Tsukii Ryota , Kitagawa Hirofumi , Fukushima Tomohisa , Urasaki Shohei , Kumada Takashi 
Published: July 2021

AbstractBackground and AimHepatic angiography procedures such as transarterial chemoembolization (TACE) are essential procedures for managing patients with hepatocellular carcinoma (HCC), and are usually performed with femoral access. However, femoral access causes patient discomfort and may be associated with the risk of hematoma or pseudoaneurysm at puncture site. We evaluated the safety, feasibility, and patient comfort of hepatic angiography procedures performed with radial access.MethodsIn this single‐institution, retrospective, time‐frame study, a total of 206 patients who underwent hepatic angiography procedures with radial access, which were first used on October 2017 at our institution, were compared with 240 patients who underwent the same procedures with femoral access before this period. Several measures were assessed, including procedure time and safety. In addition, a questionnaire was used to compare the access types regarding procedure‐associated discomfort.ResultsHepatic angiography procedures performed with radial access, including TACE, were completed in all patients without complications. The procedure time was comparable between radial access and femoral access. Most patients preferred radial to femoral access. Patients taking anticoagulants were able to complete the procedures without discontinuing these drugs.ConclusionsHepatic angiography procedures with radial access resulted in less discomfort than those with femoral access, and the two approaches showed similar feasibility and safety. Radial access can be introduced as a routine technique for hepatic angiography procedures.
On ratio measures of heterogeneity for meta‐analyses
Authors: Cairns Maxwell , Prendergast Luke A. 
Published: July 2021

AbstractAs a measure of heterogeneity in meta‐analysis, the coefficient of variation (CV) has been recently considered, providing researchers with a complement to the very popular measure. While measures the proportion of total variance that is due to variance of the random effects, the CV is the ratio of the standard deviation of the random effects to the effect of interest. Consequently, the CV provides a different measure of the extent of heterogeneity in a meta‐analysis relative to the effect being measured. However, very large CV values can occur when the effect is small making interpretation difficult. The purpose of this article is two‐fold. First, we consider variants of the CV that exist in the interval which may be preferable for some researchers. Second, we provide interval estimators for the CV and its variants with excellent coverage properties. We perform simulation studies based on simulated and real data sets and draw comparisons between the methods. For both the CV and its transformations, we recommend confidence intervals using the propagating imprecision method or, as a simpler alternative but at the expense of slightly worse performance in terms of coverage, combining reduced‐coverage confidence intervals for the two parameters. These interval estimators typically have better coverage properties for the CV measure than those previously considered.
Improving crude protein and methionine production, selective lignin degradation and digestibility of wheat straw by Inonotus obliquus using response surface methodology
Authors: Zang Qiang , Chen Xiaoxiao , Zhang Chao , Lin Mengmeng , Xu Xiangqun 
Published: July 2021

AbstractBACKGROUNDTo date, fungus‐assisted pretreatment of agricultural residue has not become the preferred method to produce protein‐enriched and ruminally digestible animal feed because of low time efficiency of fungal delignification and protein production, i.e. the long solid‐state fermentation period, and because of laccase as a potential inhibitor of cellulose activity. In this study, response surface methodology was employed to optimize the parameters in the process of producing nutritious animal feed from wheat straw with Inonotus obliquus pretreatment.RESULTSThe mineral salt solution containing (w/v) (NH4)2SO4 1%, MgSO4·7H2O 0.03%, KH2PO4 0.011%, Tween‐80 0.4%, and corn starch 10% with pH of 7.4 was optimized. Inonotus obliquus rapidly and completely colonized on wheat straw with an ergosterol content of 280 μg g−1 dry matter, consuming 45% of lignin after 15 days of fermentation, producing maximums of lignin peroxidase (1729 IU g−1), manganese peroxidase (610 IU g−1) and laccase (98 IU g−1) on days 5, 15, and 25, respectively. The crude protein (102.4 g kg−1) of 15‐day fermented wheat straw increased by ~132%. After hydrolysis, the essential protein‐bound amino acids (15.3 g kg−1) increased by ~47%, within which Met and Lys measured ~1070% and ~60% higher. The treatment with I. obliquus also improved the in vitro gas production after 72 h (IVGP72) of wheat straw to 178.8 mL g−1 organic matter (~43% increase).CONCLUSIONFor the first time, we found that I. obliquus is an effective white rot fungus turning wheat straw into ruminally digestible animal feed without laccase inhibitor.
Fresh pomegranate juices from cultivars and local ecotypes grown in southeastern Italy: comparison of physicochemical properties, antioxidant activity and bioactive compounds
Authors: Tarantino Annalisa , Difonzo Graziana , Disciglio Grazia , Frabboni Laura , Paradiso Vito Michele , Gambacorta Giuseppe , Caponio Francesco 
Published: July 2021

AbstractBACKGROUNDPomegranate juice has gained attention for its health properties, becoming consequently a highly demanded product. The revival of the pomegranate in Italy, as in other Mediterranean countries, starts with the planting of new intensive orchards characterized by both the new cultivation technique and new varieties. As a result of growing demand and high productivity, pomegranate could become an interesting crop to diversify farm income. This study seeks to determine the aril juice quality attributes and bioactive compounds of six pomegranate cultivars (‘Mollar’, ‘Dente di cavallo’, ‘Acco’, ‘Jolly red’, ‘Wonderful’ and ‘Wonderful Super’) and two local ecotypes (‘Eco BA’ and ‘Eco FG’) grown in Apulia region, southern Italy.RESULTSThe aril juices were evaluated for their main physicochemical properties (yield, color, pH, total soluble solids content, titratable acidity, sugar–acid ratio), chemical and bioactive compounds (vitamin C, phenolics, anthocyanins and antioxidant activities). ‘Eco BA’, ‘Mollar’ and ‘Jolly red’ genotypes were characterized by the highest maturity index, and then could be considered to be sweet–sour in taste. Total phenols and antioxidant activity were higher in ‘Dente di cavallo’ and ‘Eco FG’ genotypes. ‘Eco FG’ was also the richest in vitamin C, punicalagin and ellagic acids, while ‘Dente di cavallo’, ‘Acco’ and ‘Wonderful’ showed the highest content of the detected anthocyanin compounds.CONCLUSIONThese results contribute to current knowledge about chemical composition, phenolic contents, anthocyanin profiles and antioxidant activity of pomegranate juice from different genotypes, showing in most cases an appreciable juice quality and bioactive profile, although significant differences among them were detected. © 2021 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Calcium and pH interaction limits bloom formation and expansion of a nuisance microalga
Authors: Gollnisch Raphael , Alling Teodor , Stockenreiter Maria , Ahrén Dag , Grabowska Magdalena , Rengefors Karin 
Published: July 2021

AbstractMicroalgal range expansions are increasing in frequency and magnitude but generally remain unnoticed until mass development occurs. Gonyostomum semen is a freshwater raphidophyte that causes nuisance blooms in lakes and has recently expanded its distribution across Europe. G. semen was considered to mainly occur in humic lakes in the boreal region but is now found in high density also in other freshwater habitats on a larger geographic scale with growing incidence. In this study, we focused on which environmental factors limit its expansion. Our hypothesis was that G. semen occurs in many different lake types, except for high alkalinity lakes, in which high pH in combination with high calcium concentration would inhibit its growth. Results from our field study illustrate the environmental heterogeneity of G. semen bloom sites across Europe and the United States. Nevertheless, none of these sites combined high pH and high calcium concentration. In a mesocosm study, as well as a laboratory experiment, we further demonstrated that growth of G. semen is inhibited in conditions combining both high pH and high calcium concentration. We also discuss the function of Sphagnum peat mosses in rendering an alkaline habitat suitable to G. semen growth. Our study highlights that high alkalinity environments act as a major colonization barrier to G. semen. While this finding explains which environmental filters limit G. semen distribution it also helps in understanding its current expansion. With globally decreasing calcium concentrations in freshwater ecosystems, new habitats have and will become conducive to G. semen growth.
Positive framing when assessing the personal resources to manage one's finances increases consumers' retirement self‐efficacy and improves retirement goal clarity
Authors: Hoffmann Arvid O. I. , Plotkina Daria 
Published: July 2021

AbstractPeople are increasingly expected to take an active role in preparing for a financially secure future, and thus face added personal financial responsibility. Unfortunately, many consumers lack the perceived ability to engage effectively in retirement planning (i.e., retirement self‐efficacy) and accordingly fail to envision their financial future and set appropriate goals. However, little is known about how to improve consumers' retirement self‐efficacy and when and why potential policy interventions will be more or less effective. In the current paper, we address this shortcoming of prior literature. Through a series of experiments, we show that when consumers assess personal resources to achieve a financially secure future, positive framing focusing on strengths instead of weaknesses is associated with higher retirement self‐efficacy through an increased internal locus of control. Higher self‐efficacy, in turn, leads to improved retirement goal clarity, with the improvement being more pronounced for individuals having a lower consideration of future consequences. In a follow‐up study three months after the initial experimental intervention, we find that retirement goal clarity is positively associated with consumers' level of actual retirement planning activity. Finally, we replicate our findings using an advertisement as an alternative, marketing‐relevant, manipulation.
Gut Microbiota Composition is Associated with Responses to Peanut Intervention in Multiple Parameters Among Adults with Metabolic Syndrome Risk
Authors: Wang Shuo , Zhang Lingling , Wang Di , Huang Meiqin , Zhao Jingyu , Malik Vasanti , Liu Xiaoran , Sun Liang , Lin Xu , Chen Yan 
Published: July 2021

IntroductionPeanuts are widely consumed as a meal ingredient and a snack, and are commonly considered as a healthy food based on their nutrient profile. Peanut consumption has been associated with a lower risk of metabolic syndrome (MetS) in epidemiological studies. This study aims to investigate whether consuming peanuts affects the gut microbiota in adults with risk of MetS and whether the intervention effect of peanuts is associated with gut microbiota composition.Methods and ResultsThis study analyzes the gut microbiota of subjects from a 12‐week randomized clinical trial comparing consumption of either peanuts or isocaloric carbohydrate bars. It is observed that there is high inter‐individual variability on multiple clinical and anthropometrical parameters in response to peanut consumption. Meanwhile, the gut microbiota composition is also highly person‐specific and have minor changes when compared laterally or longitudinally. This study employs a machine‐learning algorithm and establishes prediction models using the microbiome data and the responsiveness data of different parameters in subjects with peanut intervention. As a result, it is found that the improvement of MetS risk and numerous parameters, including diastolic blood pressure, body weight, waist circumference, and fasting blood glucose level can be predicted for responsiveness with high accuracy that has a value of area under curve over 0.70 by receiver operating characteristic analysis.ConclusionTogether, the findings of this study suggest that individual gut microbiota configuration may modulate host metabolism and alter an individual's response to peanut intervention, thus highlighting the importance of personalized nutrition.