bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of pet in the treatment of B-cell lymphoproliferative disorders in a real-world clinical setting in Russia
Authors: Babicheva L. G. , Poddubnaya I. V. 
Published: January 2021

Objective. Assessment of the role of positron emission tomography (PET) in the diagnosis and treatment of B‑cell lymphoproliferative disorders (B-LPD) in Russian real‑world clinical practice from 2014 to 2017.Materials and Methods. The EQUILIBRIUM, a post marketing multicenter study, included 1000 patients aged 21 to 91 years with a verified diagnosis of B‑cell non‑Hodgkin»s lymphoma (B-NHL) or chronic lymphocytic leukemia (CLL) who received at least 4 cycles of rituximab‑containing therapy with Acellbia®. The main method for the assessment of the disease dissemination, the size and location of the lesions was computed tomography, which was used in 76.2 % of patients. PET was performed in 324 (32.4 %) patients: in 152 (47 %) cases during initial diagnosis, PET during treatment in 102 (31 %) patients and — in the vast majority, i. e. 310 (96 %) patients — after completion of induction chemo‑immunotherapy. Results. According to the results of interim PET, complete remission was achieved in 44 (43 %) of 102 patients, partial remission — in 53 (52 %) cases, stabilization of the disease was observed in 5 (5 %) patients, and no cases of progression among patients who underwent interim PET was detected. The main evidence of the final PET assessment efficacy was the achievement of complete remission (CR) in 235 (75.8 %) cases; partial remission (PR) was observed in only 61 (19.7 %) patients, and disease progression was reported in 14 (4.5 %) of cases. The median follow‑up was 15 months (range from 1 to 42 months). As expected, the median overall survival (OS) as well as the median event‑free survival (EFS) has not been reached for this period of time. There was a statistically significant effect of the results of interim PET on event‑free survival (p = 0.07661) without a significant effect on overall survival (p = 0.69868). The depth of response recorded during the final PET scan turned out to be a prognostically significant factor for both EFS and OS (p = 0.00000).Conclusion. Positron emission tomography is a modern and effective method for diagnosing and assessing the efficacy of therapy in B‑cell lymphoproliferative disorders, which is used for only 1 / 3 of patients in a real‑world clinical practice. Nevertheless, the role of this method in assessing the effectiveness of therapy is beyond doubt.
Prevalence of exclusive breastfeeding and factors associated with faulty feeding in southwest Bihar
Authors: Kumar Vijay , Kumar Sanjay , Nitin Gandhi Devdarshan , Kumar Mani Kant 
Published: January 2021

Background: Exclusive breastfeeding has been defined by WHO as “When an infant has been given only breast milk from his/her mother or a wet nurse or expressed breast milk during first six month of life and no other liquids/solids except necessary medicine and nutrional supplements in form of drops or syrup”. Aim was to Assess the prevalence and factors associated for faulty feeding on exclusive breast feeding practices of children less than six Months.Methods: An institution-based cross-sectional survey was conducted from May 2020 to October 2020 at Narayan medical college, Jamuhar, Rohtas, South Bihar. All mothers who visited for immunization and/or postnatal care services were considered as the study population. Lactating mothers who had under six-month infants were included. We observe the breastfeeding process for five minutes and record as per the WHO B-R-E-A-S-T feed observation form. The observation was done by asking the mother to put her infant to the breast. Results: In this present study 58.5% study subjects were given exclusive breast feeding, 36.25% study subjects were given exclusive breast feeding only for some period and rest 5.25% had not given exclusive breast feeding since birth. In this study 46% study subjects had bottle feeding habit, whereas rest 54% do not had Bottle feeding habit. Conclusions: The Exclusive Breast Feeding was satisfactory (58.5%). Some basic reason for faulty feeding were mothers’ belief that no milk, insufficient milk, baby is sick, mother is working/studying.
A clinico pathological profile of dengue fever in children in urban areas of Telangana
Authors: Swapna Reddy Kadukuntla , Krishna Surampud Sri , Mazher Naila , Sankuru Divya 
Published: January 2021

Dengue is a common disease in this part of the world. It is one of the dreaded fevers for the paediatric age group. The disease has various presentations and features, but early diagnosis and management can decrease mortality rate significantly. To evaluate the clinical profile of dengue infection in children under the age of 14 in urban areas of Telangana. The study is done in the tertiary care centre in urban area. It is Hospital based descriptive, retrospective observational study. All probable cases of dengue were admitted with provisional diagnosis of dengue fever to the department of paediatrics for a period of one year. Total 198 children of age less than 14 years participated in present study.Out of 198 samples of clinically suspected dengue cases, 192 were found positive for Dengue NS1 antigen, 145 were found to be positive by IgG and 139 cases were positive for IgM.Majority of cases are males (62%) females were 38%. Most commonly affected age group is 6- 10 years of age 95 cases (47.9%) Most of the patients in study are hospitalized for a period of 3-6 days (51.5%). Fever (99.5%) was the most common symptom found in all the patients followed by vomiting (17.7%). Hypotension was found in 9% of the patients. Severe thrombocytopenia was observed in 3.5% of patients and moderate thrombocytopenia in 7% of patients. 46.5% of patients had normal platelet count. Leukopenia was seen in 29.8% of patients. Fever was the most common symptom found in all the patients. Majority of cases showed thrombocytopenia.
Clinico - Hematological profile of dengue in children in a tertiary care hospital
Authors: Bindu M Hima , Vamsee Priya A 
Published: January 2021

Dengue is one of the febrile illnesses which is caused by the Dengue fever virus. It affects people of all ages, from the infants to the elderly and is characterized by flu-like symptoms such as fever, anorexia, nausea, vomitings. 382 children below the age of 18 years who presented with symptoms of dengue fever and were admitted into the pediatric ward and intensive care unit and tested NS1 positive or IgM positive were included into the study. Blood was collected for serological, hematological and biochemical analysis especially SGPT and SGOT. 35.3% of them had dengue fever, 62.04% had dengue hemorrhagic fever and 2.6% had dengue shock syndrome. Fever was seen in 100%, abdominal pain in 67.3%, lethargy in 75.1%, 54.4% with headache, 58.6% with joint pains. The mean hemoglobin level among the children was 10.07 ± 3.19, platelet count below 10000 was seen in 3.4% of the cases, 10000-50000 cells/mm in 12.8%. leucocyte count &#60;4 x 10in 48.2%, 4-6 x 10cells /cc in 47%, increased hematocrit in 15.2%. Increased SGPT was seen in 63.1% and elevated SGOT was in 59.2% of the patients. Since the treatment of dengue is relatively simple, the patients must be made aware to seek the medical help as soon as possible to reduce the amount of morbidity and mortality.
Prevalence of urinary tract infection and antibiotic sensitivity pattern in children with severe acute malnutrition from 6 months to 5 years in a tertiary care centre
Authors: Dewangan Mithlesh , Sharma Prateek 
Published: January 2021

The aim of the study is to evaluate the post COVID-19 transition in dentist providing dental health care to children.A cross-sectional questionnaire based survey was conducted among the dentists to assess the transition post COVID-19 towards dental health care to children. The survey was carried out with a sample of 110 respondents.The results shows that the COVID-19 outbreak had definitely made the dentists uncomfortable in treating the patients and majority (55.4%) of them agree that even children can be asymptomatic carriers. Moreover, 83.7% of the dentists agreed that the PPE kit will definitely increase the fear and anxiety among the children, 75.5% dentists agreed that this will also lead to increase in the cost of the treatment. Even before the COVID-19 pandemic majority of the dentists never used the N2O for managing the pediatric patients and even after such scenario they are not planning to use N2O for pediatric behavior management.Dental professionals must be fully aware of 2019-nCoV spreading modalities, how to identify patients with this infection, and, most importantly, self-protection considerations. The aerosols and splatter generated during dental procedures have the potential to spread infection to dental personnel and other people in the dental office. Dentists can play a significant role in disrupting the transmission chain, thereby reducing the incidence of disease by simply postponing all non-emergency dental care for all patients.
Post covid-19 Multisystermic Inflammatory Syndrome in Children (MIS-C): Case report
Authors: N Joshi Devesh , C Patel Sunil , G. Patel Maulik , R. Bhatt Hetanshi 
Published: January 2021

As we know, the spread of COVID-19 throughout 2020 has had many different manifestations in all different age groups. Our focus is the hyperinflammatory multisystemic effect it has had on the pediatric age group. Our patient, was a male child aged 9 years, presented with clinical symptoms of multisystemic inflammatory syndrome in children; a rare form of COVID-19 seen in the pediatric age group. Our patient presented with a fever and GI complaints. He subsequently developed other systemic symptoms such as a rash, along with mild breathing difficulties. His lab reports, of a positive IgG and IgM of SARS-Cov-2 antibodies and elevated inflammatory markers, were suggestive of a classic case of MIS-C. This was treated with initial intravenous steroids, followed by oral steroids.
Acute Toxicity of Quercetin From Onion Skin in Mice
Authors: Dibal Nathan Isaac , Hyedima Garba Sani , Watson Jacks Tamunotonye 
Published: January 2021

Background: Quercetin is the most abundant flavonoid molecule, is widely distributed in the plant kingdom, and has a wide range of uses.
Objectives: This study aimed to determine the LD50 of quercetin from onion (Allium cepa) skin (QOS) and its effect on the livers and kidneys of mice.
Methods: This study consisted of two phases. In phase one, 9 mice BALB/c were divided into three groups of three mice each. The mice in each group received QOS at 10 mg/kg, 100 mg/kg, and 1000 mg/kg, respectively, and were monitored for 24 h for any signs of toxicity or mortality. In phase two, three mice were divided into three groups of one mouse each. Each mouse received QOS at 1600 mg/kg, 2900 mg/kg, and 5000 mg/kg. The mice were observed for 24 h for any signs of toxicity or mortality.
Results: A significant increase was observed in serum albumin, total protein, and aspartate aminotransferase (AST) levels in mice that received 10 mg/kg, 100 mg/kg, and 1000 mg/kg QOS. A significant decrease in serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), cholesterol, creatinine, urea, and the electrolyte was noticed in mice that received QOS at 10 mg/kg, 100 mg/kg, and 1000 mg/kg when compared with the control group. The livers of mice that received 1600 mg/kg and 2900 mg/kg QOS showed hemorrhage and enlarged sinusoids along with a distortion of the renal tubule and aggregation of lymphocytes within the kidneys.
Conclusion: The LD50 of QOS was 3807 mg/kg in mice. QOS above 1000 mg/kg led to a distortion of the hepatocytes and renal tubule with an increase in serum AST, ALT, and creatinine, suggesting that QOS could be toxic at 1000 mg/kg and above.
Antibacterial and Wound Healing Activities of Topical Gel of Jatropha variegata Vahl Extract in Rats
Authors: Kassem Alzomor Abdulkarim , Mansour Sallam Nahlah , Aldeen Al-Fotaihy Shehab , Al-Moliki Bassam , Aldeen Al-Zohairy Badr 
Published: January 2021

Background: Jatropha variegata Vahl is a well-known Yemeni medicinal shrub, used traditionally to treat wounds.
Objectives: To investigate the wound-healing and antibacterial properties of the J. variegata extract as a new gel formula.
Methods: The leaves and stems of J.variegata were collected from Ibb Province, Yemen, and extracted by maceration in methanol. To ensure the quality and effectivity of the extract, physicochemical and biological investigations were conducted. Finally, the extract was prepared as a gel dosage form for bacterial and experimental animal studies. Twelve female Albino rats were divided into three groups: each rat was inflicted by three wounds. The first wound was treated thrice a day using the gel containing the J. variegata extract, the second was treated by a gel without the extract, and the third was control. The first, second, and third groups were treated for 5, 10, and 15 days, respectively, with follow-up of the wounds’ diameters. After treatment, the rats were anesthetized before analyzing the anatomy of the rats and the histological examination.
Results: The antibacterial activity of the extract was competent to the positive control against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli with a Minimum Inhibitory Concentration (MIC) of 0.05%. Similarly, 100% of the wounds healed within 15 days when treated using the gel containing the J. variegata extract. While just 33% of the control group healed.
Conclusion: J. variegata exhibited high antibacterial activity against the targeted strains and remarkable wound healing activity when applied topically on the skin of rats in a gel dosage form. This finding proves an opening for further pharmacological, toxicological, and clinical studies.
Response Surface Methodology for Optimization of Supercritical Fluid Extraction of Orange Peel Essential Oil
Authors: Ghadiri Kiana , Raofie Farhad , Qomi Mahnaz , Davoodi Ali 
Published: January 2021

Background: Orange peel essential oils were obtained using supercritical fluid extraction. This method is an important high scaling extraction method used for the extraction of plant and animal extracts.
Objectives: The aim of this study was the optimization of the extraction of the orange peel essential oil.
Methods: The experimental parameters of Supercritical Fluid Extraction (SFE) such as temperature, pressure, and extraction time, and modifier volume were optimized using a central composite design after a 24-1 fractional factorial design. Orange peels were collected from ripe orange and were washed, air dried, and milled. Then, a Suprex MPS/225 system in the SFE mode with a maximal operating pressure of 395 bars was used for essential oil extraction. Moreover, GC-MS and GC-FID were used for the identification and determination of oil compounds, respectively.
Results: Eight compounds have been identified based on their retention indices and mass spectra. According to the results, α-pinene, β-pinene, myrcene, d-limonene, terpinolene, C8-aldehyde, citronellol, and linalool were identified in orange peel essential oil. The optimum SFE conditions were obtained at a pressure of 347.07 atm, temperature of 55° C, extraction time of 30.16 min, and ethanol volume of 147.05 µL. Moreover, extraction yields based on SFE varied in the range of 0.04% to 1.18% (w/w).
Conclusion: The Results showed supercritical fluid technology as the best alternative technique for the extraction of pure and high-quality essential oil from orange peel. It is a green method and does not have any environmental impact.
Meningkatkan Keterampilan Proses Sains Peserta Didik Pada Materi Elastisitas dan Hukum Hooke Berorientasi Learner Autonomy
Authors: Hafizah Sausan , Miriam Sarah , Misbah Misbah 
Published: January 2021

Rendahnya keterampilan proses sains peserta didik dikarenakan penggunaan metode pembelajaran yang didominasi ceramah. Oleh karena itu, dilakukan penelitian untuk meningkatkan keterampilan proses sains dengan pembelajaran berorientasi learner autonomy. Jenis penelitian ini adalah penelitian tindakan kelas model Hopkins terdiri atas 2 siklus. Teknik pengumpulan data diperoleh melalui observasi dan tes. Hasil penelitian menunjukkan: (1) keterlaksanaan rencana pelaksanaan pembelajaranpada siklus I dan siklus II terlaksana dengan sangat baik; (2) keterampilan proses sains secara pada siklus I memperoleh hasil dengan kriteria baik dan siklus II memperoleh hasil dengan kriteria sangat baik; dan (3) ketuntasan hasil belajar peserta didik meningkat dari siklus I sebesar 64,29% menjadi 85,71% pada siklus II. Implementasi pembelajaran berorientasi learner autonomy mengalami peningkatan yang cukup signifikan dalam meningkatkan keterampilan proses sains peserta didik. Dengan demikian dapat disimpulkan bahwa keterampilan proses sains peserta didik di SMA Korpri Banjarmasin kelas XI MIPA dapat ditingkatkan melalui pembelajaran berorientasi learner autonomy.Students' low science process skills are due to the use of learning methods that are dominated by lectures. Therefore, this research was conducted to improve science process skills with an autonomous learner-oriented. This research is a Hopkins classroom action research model consisting of 2 cycles. The subject of the research was the students of class XI MIPA Korpri High School Banjarmasin. Data collection techniques were obtained through observation and tests. The results showed: (1) the implementation of the lesson plan implementation sheets in cycle I and cycle II was implemented very well; (2) science process skills in cycle I get results with good criteria and cycle II gets results with very good criteria; and (3) The completeness of the results of study participants students increased from cycle I amounted to 64.29% into 85.71% in cycle II. The implementation of learning, which is oriented towards students' learner autonomy, is significant enough to improve students' process skills. Thus it can be concluded that the science process skills of students in the Korpri High School Banjarmasin at MIPA XI class can be improved through autonomous learner oriented learning.
Pengembangan Bahan Ajar Fisika Topik Elastistas Menggunakan Model Pengajaran Langsung untuk Melatihkan Kemampuan Pemecahan Masalah Peserta Didik
Authors: Ramadhanti Ramadhanti , Mastuang Mastuang , Mahardika Andi Ichsan 
Published: January 2021

Bahan ajar di MAN 3 Banjarmasin belum dirancang untuk melatihkan kemampuan pemecahan masalah peserta didik sehingga kemampuan pemecahan masalah peserta didik masih rendah. Tujuan penelitian ini yaitu menghasilkan bahan ajar fisika topik elastisitas menggunakan model pengajaran langsung yang layak digunakan untuk melatihkan kemampuan pemecahan masalah peserta didik. Kelayakan dilihat dari validitas, kepraktisan, dan efektivitas. Jenis penelitian ini adalah penelitian pengembangan, dengan desain penelitian menggunakan model ADDIE, diujicobakan pada 32 peserta didik kelas XI MIA 2 MAN 3 Banjarmasin. Data diperoleh melalui instrumen penilaian validitas perangkat pembelajaran, lembar keterlaksanaan Rencana Pelaksanaan Pembelajaran (RPP), dan tes pemecahan masalah. Data dianalisis secara deskriptif kualitatif dan kuantitatif. Hasil penelitian menunjukkan: (1) Bahan ajar (RPP, lembar kerja peserta didik, materi ajar, tes hasil belajar) model pengajaran langsung yang dikembangkan berkategori valid (2) Bahan ajar model pengajaran langsung terlaksana dengan kategori sangat praktis, (3) Bahan ajar langsung berkategori efektif karena nilai N-Gain pemecahan masalah sebesar 0,66 dalam kategori sedang. Diperoleh simpulan bahwa perangkat pengajaran langsung yang dikembangkan layak digunakan untuk melatihkan kemampuan pemecahan masalah peserta didik.Learning materials in MAN 3 Banjarmasin have not been designed to train students problem-solving skills so that students' problem-solving skills are still low. Therefore, this study aims to produce a valid, practical, and effective direct instruction model so that it is suitable to be used to train students' problem-solving skills. This type of research is development research, where the research design used the ADDIE model and is tested for 32 students of class XI MIA 2 MAN 3 Banjarmasin. Data were obtained through learning materials validation instruments, lesson plan implementation sheets, and problem-solving tests. Data were analyzed qualitatively and quantitatively. The results of the study showed: (1) learning materials of direct instruction were in valid category; (2) learning materials with direct instruction model were in very, (3) learning materials of direct instruction model is effective because the N-Gain value is 0.66; means an increase in the medium category. It was concluded that learning devices with the direct instruction model developed were feasible to train students problem-solving skills.
Pengembangan Perangkat Pembelajaran Berbasis Proyek untuk Meningkatkan Keterampilan Proses Sains Peserta Didik
Authors: Dwiyanti Erdian , Rosana Dadan 
Published: January 2021

Penelitian ini bertujuan mengembangkan perangkat pembelajaran berbasis proyek untuk, (1) mengetahui tingkat kelayakan, (2) mengetahui efektivitas perangkat pembelajaran berbasis proyek, dan (3) mengetahui tingkat penguasaan keterampilan proses sains dan tingkat penguasaan materi peserta didik pada materi suhu dan kalor dengan menggunakan perangkat pembelajaran berbasis proyek. Penelitian ini merupakan penelitian pengembangan hasil modifikasi model pengembangan Borg & Gall. Hasil penelitian menunjukkan bahwa: (1) prosedur pengembangan model perangkat pembelajaran berbasis proyek mengadopsi dan memodifikasi model R & D (Borg & Gall) memperoleh nilai A dengan kategori sangat baik; (2) Efektivitas perangkat pembelajaran berbasis proyek dari guru dan observer pada aspek validitas, realibilitas, objektivitas, kepraktisan, sistematis dan Bahasa pada kategori cukup baik, dan (3) ketercapaian keterampilan proses sains peserta didik pada kelas eksperirmen mencapai 86.07% sedangkan pada kelas kontrol hanya 63.48%, Adapun penguasaan materi ditinjau dari persentase peserta didik di kelas eksperimen yang mencapai KKM sebesar 96.87% sedangkan peserta didik di kelas kontrol 6.25%. This study aims to develop project-based learning tools, (1) to determine the feasibility of the products developed; (2) determine the effectiveness of the project-based learning, and (3) determine the level of mastery of science process skills and the level of mastery of the material students in the material and the temperature of the heat by using project-based learning. This research is the development of a modified model of the development of Borg & Gall. Research activities consist of three phases: development limited, testing and expanded trials. The results show that: (1) the procedure of model development project-based learning tools adopt and modify the model of R & D (Borg & Gall) obtaining an A in the category of very good; (2) The effectiveness of project-based learning teacher and observer to the aspect of validity, reliability, objectivity, practicality, and systematic language category is average categories, and (3) The achievement of students' science process skills in the experiment reached 86.07% while in the control class it was only 63.48%. The mastery of the material based on the proportion of students in the experimental class who achieved KKM was 96.87%, while students in the control class were 6.25%.