bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lack of specialist nidicoles as a characteristic of mite assemblages inhabiting nests of the ground-nesting wood warbler, Phylloscopus sibilatrix (Aves: Passeriformes)
Authors: Napierała Agnieszka , Maziarz Marta , Hebda Grzegorz , Broughton Richard K. , Rutkowski Tomasz , Zacharyasiewicz Michał , Błoszyk Jerzy 
Published: May 2021

AbstractBird and mammal nests provide microhabitats that support a range of other species, including invertebrates. However, the variation between communities of nest-dwelling invertebrates in different nests is poorly understood. The major aim of this study was to analyze the assemblage structure of mites from the suborder Uropodina (Acari: Mesostigmata) and from superfamily Crotonioidea (Acari: Oribatida) inhabiting nests of the wood warbler, Phylloscopus sibilatrix (Aves: Passeriformes), located on a forest floor in Białowieża Forest, in eastern Poland. We also assessed the correlation between the nest material used by the birds with the assemblage structure of Uropodina mites, and compared the results with published studies of the nests of other birds and a mammal (common mole, Talpa europaea), and also with communities of mites inhabiting the soil. The field research was conducted in the strict nature reserve of the Białowieża National Park, a near-primeval European temperate forest. In 2019, immediately after the breeding period, 69 wood warbler nests and 439 soil samples were collected. Analyses revealed assemblages of Uropodina mites inhabiting the nests that consisted of 14 species, mostly common soil species. Only five species of oribatid mites from superfamily Crotonioidea were present in the nest material. Analyzed nests had a high percentage of tree leaves and grass blades, whereas moss was the least frequent component of the nest material. The Uropodina mites were more abundant in the nests that had greater amounts of grass blades, but similar relationships were insignificant for the nests with varying amounts of tree leaves or moss. The assemblages of Uropodina mites inhabiting wood warbler nests were very similar to those found in soil and nests of the common mole, but they lacked typical nest-dwelling species of Uropodina (i.e., specialized nidicoles).
The Influence of Quantum Physics on Philosophy
Authors: Muller F. A. 
Published: May 2021

AbstractWe ponder the question whether quantum physics has had any influence on philosophy, and if not, whether it ought to have had any. Answers to these questions are provided, and they turn out to depend onwhichbranch of the tree of philosophy we sweep, sway and swing, and evenwhichtwig of the branch we touch when we sweep, sway and swing.
Optimization-driven framework to understand health care network costs and resource allocation
Authors: Bravo Fernanda , Braun Marcus , Farias Vivek , Levi Retsef , Lynch Christine , Tumolo John , Whyte Richard 
Published: May 2021

AbstractIn the last several decades, the U.S. Health care industry has undergone a massive consolidation process that has resulted in the formation of large delivery networks. However, the integration of these networks into a unified operational system faces several challenges. Strategic problems, such as ensuring access, allocating resources and capacity efficiently, and defining case-mix in a multi-site network, require the correct modeling of network costs, network trade-offs, and operational constraints. Unfortunately, traditional practices related to cost accounting, specifically the allocation of overhead and labor cost to activities as a way to account for the consumption of resources, are not suitable for addressing these challenges; they confound resource allocation and network building capacity decisions. We develop a general methodological optimization-driven framework based on linear programming that allows us to better understand network costs and provide strategic solutions to the aforementioned problems. We work in collaboration with a network of hospitals to demonstrate our framework applicability and important insights derived from it.
Childhood Disintegrative Disorder (CDD): Symptomatology of the Norwegian Patient Population and Parents’ Experiences of Patient Regression
Authors: Ellis Martin John , Larsen Kenneth , Havighurst Sophie Seychelle 
Published: May 2021

AbstractChildhood Disintegrative Disorder (CDD) is a rare and little researched developmental disorder characterised by regression in language and social skills after a period of seemingly normal development until at least the age of 2 years. The study contacted all parents of CDD patients in Norway to assess patient symptomatology and parents’ experiences of regression via questionnaire or interview. There were 12 participants. Symptomatology was in-line with previous studies, with universal regression in language and social skills and onset predominantly at 2–4 years. Regression was connected to feelings of ‘loss’ and uncertainty over the prognosis for CDD patients. The study supported CDD diagnostic criteria and showed that CDD patient regression has profound implications for parental well-being.
STAT3 Hyper-IgE Syndrome—an Update and Unanswered Questions
Authors: Tsilifis Christo , Freeman Alexandra F. , Gennery Andrew R. 
Published: May 2021

AbstractThe hyper-IgE syndromes (HIES) are a heterogeneous group of inborn errors of immunity sharing manifestations including increased infection susceptibility, eczema, and raised serum IgE. Since the prototypical HIES description 55 years ago, areas of significant progress have included description of key disease-causing genes and differentiation into clinically distinct entities. The first two patients reported had what is now understood to be HIES from dominant-negative mutations in signal transduction and activator of transcription 3 (STAT3-HIES), conferring a broad immune defect across both innate and acquired arms, as well as defects in skeletal, connective tissue, and vascular function, causing a clinical phenotype including eczema, staphylococcal and fungal skin and pulmonary infection, scoliosis and minimal trauma fractures, and vascular tortuosity and aneurysm. Due to the constitutionally expressed nature of STAT3, initial reports at treatment with allogeneic stem cell transplantation were not positive and treatment has hinged on aggressive antimicrobial prophylaxis and treatment to prevent the development of end-organ disease such as pneumatocele. Research into the pathophysiology of STAT3-HIES has driven understanding of the interface of several signaling pathways, including the JAK-STAT pathways, interleukins 6 and 17, and the role of Th17 lymphocytes, and has been expanded by identification of phenocopies such as mutations in IL6ST and ZNF341. In this review we summarize the published literature on STAT3-HIES, present the diverse clinical manifestations of this syndrome with current management strategies, and update on the uncertain role of stem cell transplantation for this disease. We outline key unanswered questions for further study.
Coupled diffusion and phase transition: Phase fields, constraints, and the Cahn–Hilliard equation
Authors: Duda Fernando P. , Sarmiento Adel F. , Fried Eliot 
Published: May 2021

AbstractWe develop a constrained theory for constituent migration in bodies with microstructure described by a scalar phase field. The distinguishing features of the theory stem from a systematic treatment and characterization of the reactions needed to maintain the internal constraint given by the coincidence of the mass fraction and the phase field. We also develop boundary conditions for situations in which the interface between the body and its environment is structureless and cannot support constituent transport. In addition to yielding a new derivation of the Cahn–Hilliard equation, the theory affords an interpretation of that equation as a limiting variant of an Allen–Cahn type diffusion system arising from the unconstrained theory obtained by considering the mass fraction and the phase field as independent quantities. We corroborate that interpretation with three-dimensional numerical simulations of a recently proposed benchmark problem.
Sentiment analysis of popular-music references to automobiles, 1950s to 2010s
Authors: Wu Chenyang , Le Vine Scott , Bengel Elizabeth , Czerwinski Jason , Polak John 
Published: May 2021

AbstractIn recent years, there has been a scholarly debate regarding the decrease in automobile-related mobility indicators (car ownership, driving license holding, VMT, etc.). Broadly speaking, two theories have been put forward to explain this trend: (1) economic factors whose impacts are well-understood in principle, but whose occurrence among young adults as a demographic sub-group had been overlooked, and (2) less well-understood shifts in cultural mores, values and sentiment towards the automobile. This second theory is devilishly difficult to study, due primarily to limitations in standard data resources such as the National Household Travel Survey and international peer datasets. In this study we first compiled a database of lyrics to popular music songs from 1956 to 2015 (defined by inclusion in the annual “top 40”), and subsequently identified references to automobiles within this corpus. We then evaluated whether there is support for theory #2 above within popular music, by looking at changes from the 1950s to the 2010s. We demonstrate that the frequency of references to automobility tended for many years to increase over time, however there has more recently been a decline after the late 2000s (decade). In terms of the sentiment of popular music lyrics that reference automobiles, our results are mixed as to whether the references are becoming increasingly positive or negative (machine analysis suggests increasing negativity, while human analysis did not find a significant association), however a consistent observation is that sentiment of automobile references have over time become more positive relative to sentiment of song lyrics overall. We also show that sentiment towards automobile references differs systematically by genre, e.g. automobile references within ‘Rock’ lyrics are in general more negative than similar references to cars in other music genres). The data generated on this project have been archived and made available open access for use by future researchers; details are in the full paper.
Quantification of NAD(P)H in cyanobacterial cells by a phenol extraction method
Authors: Tanaka Kenya , Shimakawa Ginga , Tabata Hiro , Kusama Shoko , Miyake Chikahiro , Nakanishi Shuji 
Published: May 2021

AbstractIn photosynthetic organisms, it is recognized that the intracellular redox ratio of NADPH is regulated within an appropriate range for the cooperative function of a wide variety of physiological processes. However, despite its importance, there is large variability in the values of the NADPH fraction [NADPH/(NADPH + NADP+)] quantitatively estimated to date. In the present study, the light response of the NADPH fraction was investigated by applying a novel NADP(H) extraction method using phenol / chloroform / isoamyl alcohol (PCI) in the cyanobacterium Synechocystis sp. PCC 6803. The light response of NADP(H) observed using PCI extraction was qualitatively consistent with the NAD(P)H fluorescence time course measured in vivo. Moreover, the results obtained by PCI extraction and the fluorescence-based methods were also consistent in a mutant lacking the ability to oxidize NAD(P)H in the respiratory chain, and exhibiting a unique NADPH light response. These observations indicate that the PCI extraction method allowed quantitative determination of NADP(H) redox. Notably, the PCI extraction method showed that not all NADP(H) was oxidized or reduced by light–dark transition. Specifically, the fraction of NADPH was 42% in the dark-adapted cell, and saturated at 68% in light conditions.
Evaluate and control service and transaction dependability of complex IoT systems
Authors: Niedermaier Sina , Zelenik Thommy , Heisse Stefan , Wagner Stefan 
Published: May 2021

AbstractObserving and controlling the dependability of service provision of complex IoT systems is challenging. In practice, many organizations struggle to derive consumer needs related to quality and to observe and quantify the service provision in the context of the dynamic behavior of a complex distributed system. In this paper, we present an approach to define and evaluate the dependability of complex IoT systems. Our approach is an adaptation of the ISO/IEC 25040, an international standard for the evaluation process for system and software quality, which is part of the systems and software quality requirements and evaluation (SQuaRE) series. Our approach was designed and evaluated with action research in an industrial study at Robert Bosch GmbH. Based on the framework of the SQuaRE series, we integrated different elements of site reliability engineering (SRE) and combined them with distributed tracing as a promising measurement method. Our approach introduces the IoT transaction concept to reduce modeling and observation efforts while increasing operationalization to measure performance against dependability targets. Our adaption was effectively applied, consumer-centricity along different system stakeholders were enhanced, and negative consequences of organizational silos were reduced. This has improved the dependability evaluation of service provision to enable fast feedback cycles for service performance control and improvement.
An integrated assessment of the impacts of PM2.5 and black carbon particles on the air quality of a large Brazilian city
Authors: Gidhagen Lars , Krecl Patricia , Targino Admir Créso , Polezer Gabriela , Godoi Ricardo H. M. , Felix Erika , Cipoli Yago A. , Charres Isabella , Malucelli Francisco , Wolf Alyson , Alonso Marcelo , Segersson David , Castelhano Francisco J. , Amorim Jorge H. , Mendonça Francisco 
Published: May 2021

AbstractData on airborne fine particle (PM2.5) emissions and concentrations in cities are valuable for traffic and air quality managers, urban planners, health practitioners, researchers, and ultimately for legislators and decision makers. Emissions and ambient concentrations of PM2.5 and black carbon (BC) were assessed in the city of Curitiba, southern Brazil. The methodology combined a month-long monitoring campaign with both fixed and mobile instruments, development of emission inventories, and dispersion model simulations on different scales. The mean urban background PM2.5 concentrations during the campaign were 7.3 μg m−3 in Curitiba city center, but three- to fourfold higher (25.3 μg m-3) in a residential area on the city’s outskirts, indicating the presence of local sources, possibly linked to biomass combustion. BC concentrations seemed to be more uniformly distributed over the city, with mean urban background concentrations around 2 μg m−3, half of which due to local traffic emissions. Higher mean BC concentrations (3–5 μg m-3) were found along busy roads. The dispersion modeling also showed high PM2.5 and BC concentrations along the heavily transited ring road. However, the lack of in situ data over these peripheral areas prevented the verification of the model output. The vehicular emission factors for PM2.5 and BC from the literature were found not to be suitable for Curitiba’s fleet and needed to be adjusted. The integrated approach of this study can be implemented in other cities, as long as an open data policy and a close cooperation among regional, municipal authorities and academia can be achieved.
The Cytoskeletal Elements MAP2 and NF-L Show Substantial Alterations in Different Stroke Models While Elevated Serum Levels Highlight Especially MAP2 as a Sensitive Biomarker in Stroke Patients
Authors: Mages Bianca , Fuhs Thomas , Aleithe Susanne , Blietz Alexandra , Hobusch Constance , Härtig Wolfgang , Schob Stefan , Krueger Martin , Michalski Dominik 
Published: May 2021

AbstractIn the setting of ischemic stroke, the neurofilament subunit NF-L and the microtubule-associated protein MAP2 have proven to be exceptionally ischemia-sensitive elements of the neuronal cytoskeleton. Since alterations of the cytoskeleton have been linked to the transition from reversible to irreversible tissue damage, the present study investigates underlying time- and region-specific alterations of NF-L and MAP2 in different animal models of focal cerebral ischemia. Although NF-L is increasingly established as a clinical stroke biomarker, MAP2 serum measurements after stroke are still lacking. Therefore, the present study further compares serum levels of MAP2 with NF-L in stroke patients. In the applied animal models, MAP2-related immunofluorescence intensities were decreased in ischemic areas, whereas the abundance of NF-L degradation products accounted for an increase of NF-L-related immunofluorescence intensity. Accordingly, Western blot analyses of ischemic areas revealed decreased protein levels of both MAP2 and NF-L. The cytoskeletal alterations are further reflected at an ultrastructural level as indicated by a significant reduction of detectable neurofilaments in cortical axons of ischemia-affected areas. Moreover, atomic force microscopy measurements confirmed altered mechanical properties as indicated by a decreased elastic strength in ischemia-affected tissue. In addition to the results from the animal models, stroke patients exhibited significantly elevated serum levels of MAP2, which increased with infarct size, whereas serum levels of NF-L did not differ significantly. Thus, MAP2 appears to be a more sensitive stroke biomarker than NF-L, especially for early neuronal damage. This perspective is strengthened by the results from the animal models, showing MAP2-related alterations at earlier time points compared to NF-L. The profound ischemia-induced alterations further qualify both cytoskeletal elements as promising targets for neuroprotective therapies.
What We Can Learn From Literary Authors
Authors: Voltolini Alberto 
Published: May 2021

AbstractThat we can learn something from literature, as cognitivists claim, seems to be a commonplace. However, when one considers matters more deeply, it turns out to be a problematic claim. In this paper, by focusing on general revelatory facts about the world and the human spirit, I hold that the cognitivist claim can be vindicated if one takes it as follows. We do not learn such facts from literature, if by “literature” one means the truth-conditional contents that one may ascribe to textual sentences in their fictional use, i.e., in the use in which one makes believe that things unfold in a certain way. What we improperly call learning from literature amounts to knowing actually true conversational implicatures concerning the above facts as meant by literary authors. So, in one and the same shot, we learn both a general revelatory fact and the fact that such a fact is meant via a true conversational implicature by an author. The author draws that implicature from the different truth-conditional content a sentence possesses when the sentence is interpreted in a fictional context, meant as Kaplan’s (1989) narrow context, i.e., a set of circumstantial parameters (agent, space, time, and world).
Human Papillomavirus, Related Diseases, and Vaccination: Knowledge and Awareness Among Health Care Students and Professionals in Nepal
Authors: Suhaila Khawla , Mukherjee Amrita , Maharjan Bipu , Dhakal Amrit , Lama Mingma , Junkins Anna , Khakurel Uddhav , Jha Alok Nath , Jolly Pauline E. , Lhaki Pema , Shrestha Sadeep 
Published: May 2021

AbstractHuman papillomavirus (HPV) is a common sexually transmitted disease worldwide. While burden of HPV-associated cancers and mortality is higher in low-income countries, there is limited data about knowledge of it among health care students and professionals. We assessed awareness and knowledge of HPV, its related diseases, and HPV vaccine among 333 participants, composed of 146 medical students (MSs) and professionals (MPs) and 187 nursing students (NSs) and professionals (NPs) using a 40-question survey between July 2018 and February 2019. Surveys were conducted in English language using both paper and an online version. Most participants reported that they had heard of HPV and cervical cancer. However, 91.76% of MPs and 77.97% of MSs, but only 41.11% of NPs and 36.17% NSs reported knowing that HPV types 16 and 18 caused cervical cancer. Likewise, about two-thirds of MPs and MSs reported having the knowledge that HPV 6 and 11 caused genital warts versus only a little over one-fourth of NPs and NSs. Only 55.91% of NPs and 51.61% of NSs were aware that HPV could cause cancer in both men and women, whereas 42.35% of MPs, 64.41% of MSs, 41.76% of NPs, and 40.66% of NSs were aware that the vaccine could be given to both boys and girls. While medical professionals were relatively more knowledgeable about HPV and related diseases, overall, knowledge about the HPV vaccine was low among all groups. This knowledge gap is concerning and warrants further attention to fight HPV-related public health burden in Nepal.
Dehydroaromatization of methane over noble metal loaded Mo/H-ZSM-5 zeolite catalysts
Authors: Tshabalala Themba E. , Coville Neil J. , Anderson James A. , Scurrell Michael S. 
Published: May 2021

AbstractDehydroaromatization of methane (MDA) reaction was investigated over platinum modified Mo/H-ZSM-5 catalysts which were pre-carbided at 750 °C. The influence of platinum on the catalytic performance and product selectivity of Mo/H-ZSM-5 catalysts for the MDA reaction at 700 °C were studied. The presence of platinum led to a slight decrease in methane conversion from 7.5 to 4.2%. Aromatic selectivities above 90% were obtained with catalysts containing low platinum loadings (0.5 and 1.0 wt.%), with benzene being the most prominent product. A decrease in coke selectivity and coke deposits was noted with the platinum modified Mo/H-ZSM-5 zeolite catalysts. A comparative study was performed to compare platinum, palladium and ruthenium promoted Mo/H-ZSM-5 zeolite catalysts with un-promoted Mo/H-ZSM-5. The ruthenium promoted catalyst proved to be superior in catalytic performance, with a higher methane conversion obtained than that found for platinum promoted and palladium promoted Mo/H-ZSM-5 catalysts. Benzene selectivity of about 60% was obtained for ruthenium and palladium promoted Mo/H- ZSM-5 catalysts and the total aromatic selectivity was maintained at 90%. TGA results showed a total reduction of 50% by weight of carbon deposited on the promoted Mo/H-ZSM-5 catalyst.
Graphic abstract