bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chinese Herbal Products for Non-Motor Symptoms of Parkinson’s Disease in Taiwan: A Population-Based Study
Authors: Lin Chien-Hung , Chiu Hsienhsueh Elley , Wu Szu-Ying , Tseng Shih-Ting , Wu Tzu-Chan , Hung Yu-Chiang , Hsu Chung Y. , Chen Hsuan-Ju , Hsu Sheng-Feng , Kuo Chun-En , Hu Wen-Long 
Published: January 2021

Objective: Combinations of Chinese herbal products (CHPs) are widely used for Parkinson’s disease (PD) in Taiwan. Thereby, we investigated the use of CHPs in patients with PD.Methods: This study was a population-based cohort study that analyzed the data of patients with PD from the National Health Insurance Research Database. A total of 9,117 patients were selected from a random sample of one million individuals included in this database. We used multiple logistic regression models to estimate the adjusted odds ratios of the demographic factors and analyzed the formula and single CHPs commonly used for PD.Results: Traditional Chinese medicine users were more commonly female, younger, of white-collar status, and residents of Central Taiwan. Chaihu-Jia-Longgu-Muli-Tang was the most commonly used formula, followed by Ma-Zi-Ren-Wan and then Shao-Yao-Gan-Cao-Tang. The most commonly used single herb was Uncaria tomentosa (Willd. ex Schult.) DC., followed by Gastrodia elata Blume and then Radix et Rhizoma Rhei (Rheum palmatum L., Rheum tanguticum Maxim. ex Balf., and Rheum officinale Baill.). Chaihu-Jia-Longgu-Muli-Tang and U. tomentosa (Willd. ex Schult.) DC. have shown neuroprotective effects in previous studies, and they have been used for managing non-motor symptoms of PD.Conclusion: Chaihu-Jia-Longgu-Muli-Tang and U. tomentosa (Willd. ex Schult.) DC. are the most commonly used CHPs for PD in Taiwan. Our results revealed the preferences in medication prescriptions for PD. Further studies are warranted to determine the effectiveness of these CHPs for ameliorating the various symptoms of PD, their adverse effects, and the mechanisms underlying their associated neuroprotective effects.
Synthesis, Anti-Tumor Activity and Apoptosis-Inducing Effect of Novel Dimeric Keggin-Type Phosphotungstate
Authors: Xue Yingxue , Yin Yifei , Li He , Chi Mingyu , Guo Jiaxin , Cui Guihua , Li Wenliang 
Published: January 2021

A dimeric Keggin-type phosphotungstate (ODA)10[(PW11FeO39)2O]·9H2O (abbreviated as ODA10[(PW11Fe)2], ODA = octadecyltrimethylammonium bromide) was synthesized and investigated comprehensively its antitumor activity on MCF-7 and A549 cells. The dimeric structure and amorphous morphology were characterized by FT-IR, UV-vis-DRS, SEM and XRD. The in vitro MTT assay of ODA10[(PW11Fe)2] showed anticancer activity on MCF-7 and A549 cells in a dose- and time-dependent manner, and the IC50 values for MCF-7 and A549 cells at 48 h were 5.83 μg/ml and 3.23 μg/ml, respectively. The images of the ODA10[(PW11Fe)2]-treated cells observed by inverted biological microscope exhibited the characteristic morphology of apoptosis. Flow cytometric analysis showed cell apoptosis and cycle arrested at S phase induced by ODA10[(PW11Fe)2]. The above results illuminated the main mechanism of the antitumor action of ODA10[(PW11Fe)2] on MCF-7 and A549 cells, indicating that this dimeric phosphotungstate is a promising anticancer drug.
Properties and Use of Water Activated by Plasma of Piezoelectric Direct Discharge
Authors: Konchekov Evgeny M. , Glinushkin Alexey P. , Kalinitchenko Valery P. , Artem’ev Konstantin V. , Burmistrov Dmitry E. , Kozlov Valery A , Kolik Leonid V. 
Published: January 2021

The distilled water was exposed to a cold atmospheric plasma (CAP) generated by the piezotransformer. The treatment was carried out on a six-well plate. Exposure time was from 30 s to 10 min. The emission spectra were obtained. Physical and chemical changes of activated water were observed for 8 days. The reactive oxygen and nitrogen species (RONS) were investigated. RONS production dependence on the exposure time and RONS lifetime in the treated liquid was determined using absorbance spectra. Quantitative assessment was made of the nitrite and nitrate concentration change over time after treatment. The medium conductivity and redox potential varied linearly depending on exposure time. The pH value change correlates with nitrate anion concentration. The concentration of peroxide hydrogen increased depending on CAP water treatment duration. The RONS concentration after liquid media processing with piezoelectric direct discharge CAP is a novel result. Biogeosystem Technique provides CAP activated water agriculture synergetic effect.
The ECG Characteristics of Patients With Isolated Hypomagnesemia
Authors: Yang Yiheng , Chen Cheng , Duan Penghong , Thapaliya Suman , Gao Lianjun , Dong Yingxue , Yin Xiaomeng , Yang Xiaolei , Zhang Rongfeng , Tan Ruopeng , Hui Simei , Wang Yue , Sutton Richard , Xia Yunlong 
Published: January 2021

BackgroundElectrocardiographic (ECG) characteristics of patients with isolated hypomagnesemia are not well defined. We aimed to investigate these ECG characteristics in order to define clearly the features of isolated hypomagnesemia.HypothesisLower serum magnesium could affect ECG parameters after excluding potential confounders.MethodsThis retrospective study was of patients with low serum magnesium &lt;0.65 mmol/L compared with the same patients after restoration to normal serum magnesium. Patients with hypokalemia, hypocalcemia and other electrolyte disturbances were excluded. ECG parameters manually determined and analyzed were P wave dispersion, PR interval, QRS duration, ST-T changes, T wave amplitude, T peak-to-end interval (Tpe), corrected Tpe (Tpec), QT, corrected QT (QTc), QT peak corrected (QTpc) and Tpe dispersion, Tpe/QT ratio.ResultsTwo-hundred-and-fourteen patients with isolated hypomagnesemia were identified with 50 of them (56.9 ± 13.6 years; 25 males) being eligible for final analysis from 270,997 patients presenting April 2011–October 2017. In the period of isolated hypomagnesemia, P wave duration was found prolonged (p ≤ 0.02); as was QTc (439 ± 27 vs. 433 ± 22, p = 0.01). Tpec (122 ± 24vs. 111 ± 22, p = 0.000) and Tpe/QT ratio (0.29 ± 0.05 vs. 0.27 ± 0.05, p = 0.000) were increased. QTpc decreased during hypomagnesemia (334 ± 28 vs. 342 ± 21, p = 0.02). However, no significant differences were found in PR interval, QRS duration (85 ± 12 ms vs. 86 ± 12 ms, p = 0.122) and ST-T segments between the patients and their own controls.ConclusionsIn patients with isolated hypomagnesemia, P wave duration, QTc, Tpec, and Tpe/QT ratio suggesting atrial depolarization and ventricular repolarization dispersion were significantly increased compared with normal magnesium levels in the same patients after restoration to normal levels.
Study of the SCL-90 Scale and Changes in the Chinese Norms
Authors: Dang Weimin , Xu Yajuan , Ji Jun , Wang Ke , Zhao Songtao , Yu Bin , Liu Jinming , Feng Chaonan , Yu Haokui , Wang Wenqiang , Yu Xin , Dong Wentian , Ma Yantao 
Published: January 2021

Objective: This study aimed to investigate the Chinese norms for the Symptom Checklist 90 (SCL-90) scale and its application.Methods: In total, 7,489 adults from Tianjin and Qingdao in China were included. Their data were compared with the norm data of 1,388 people published by Jin et al., the combined norms published by Tang et al., the data of 2,808 adults published by Chen and Li, and the data of 1,890 adults from Tong in China.Results: In five different periods, notable changes were observed in each factor of the SCL-90 that significantly differed from the previous norms. The scores of each factor showed an increasing annual trend. Compulsion consistently obtained the highest scores, and phobia consistently obtained the lowest scores. The scores tended to decrease from compulsion to anxiety, and psychosis scored lower than paranoia. There was a significant difference in the detection rate between the critical screening value of two points and the standard score. Using the standard score as the critical value, the detection rate ranged between 13 and 16% and was relatively concentrated. Using two points as the critical value, the detection rate ranged between 38 and 50%.Conclusion: The usual model in China is not consistent with social development. Using two points as the critical value is no longer suitable for the SCL-90. New Chinese norms and measurement standards should be developed. The mean value plus one standard deviation could be used as the new measurement standard.
Demand Analysis of a Psychiatric Emergency Room and an Adolescent Acute Inpatient Unit in the Context of the COVID-19 Pandemic in Madrid, Spain
Authors: Díaz de Neira Mónica , Blasco-Fontecilla Hilario , García Murillo Lourdes , Pérez-Balaguer Ana , Mallol Leticia , Forti Azul , Del Sol Pablo , Palanca Inmaculada 
Published: January 2021

Introduction: COVID-19 represents a serious threat to mental health worldwide. The aim of this study is to identify changes in adolescent psychiatry treatment demand in a tertiary hospital in Madrid during the first month (March 11 to April 11) after the pandemic declaration by the World Health Organization (WHO). We hypothesized that fear of contagion within COVID-19 may deter people from asking for psychiatric care.Method: The current study is retrospective, observational, and transversal. We reviewed the clinical records of 89 adolescents who went to the Emergency Room (ER) or were hospitalized at the Acute Inpatient Unit (AIU) at the Puerta de Hierro University Hospital-Majadahonda (PHUH-M) between March 11 and April 11. Socio-demographic, clinical, and demand variables were included in the study. Chi-square or Fisher exact tests were performed to compare categorical variables. We used the U Mann-Whitney test to compare quantitative variables. The level of statistical significance was set at p&lt; 0.05. Analyses were conducted using SPSS v11.0.Results: The number of adolescents demanding psychiatric care at the ER dropped from 64 adolescents in 2019 to 25 in 2020. Similarly, psychiatric demand collapsed from 31 to 18 patients when comparing 2019 and 2020. Furthermore, the average hospital stay in 2020 trended toward a decrease when compared to 2019 (8.94 ± 4.87 vs. 14.32 ±10.23, p = 0.08). Self-injurious thoughts and behaviors were the most predominant reasons for consultation at both ER and AIU.Conclusion: The demand for adolescent psychiatric care decreased in the first month after the declaration of the pandemic. Our findings may be explained by (1) the fear of contagion, (2) the strict confinement measures, and (3) the initial shock as an adaptive reaction described in other disasters. Further studies are needed.
Using Health Insurance Network Provider Data and Public Data Sets to Identify SARS-CoV-2 Vaccinators in the USA
Authors: Litaker John R. , Tamez Naomi , Durkalski Wesley , Taylor Richard 
Published: January 2021

Objective: Mass vaccination planning is occurring at all levels of government in advance of regulatory approval and manufacture of a SARS-CoV-2 vaccine for distribution sometime in 2021. We outline a methodology in which both health insurance provider network data and publicly available data sources can be used to identify and plan for SARS-CoV-2 vaccinator capacity at the county level.Methods: Sendero Health Plans, Inc. provider network data, Texas State Board of Pharmacy data, US Census Bureau data, and H1N1 monovalent vaccine data were utilized to identify providers with demonstrated capacity to vaccinate the population in Travis County, Texas to achieve an estimated SARS-CoV-2 herd immunity target of 67%.Results: Within the Sendero network, 2,356 non-pharmacy providers were identified with 788 (33.4%) practicing in primary care and 1,569 (66.6%) practicing as specialists. Of the total, 686 (29.1%) provided at least one immunization between January 1, 2019 and September 30, 2020. There are 300 pharmacies with active licenses in Travis County with 161 (53.7%) classified as community pharmacies. We estimate that 1,707,098 doses of a 2-dose SARS-CoV-2 vaccine series will need to be administered within Travis County, Texas to achieve the estimated 67% herd immunity threshold to disrupt person-to-person transmission of the SARS-CoV-2 virus based on 2020 census data.Conclusion: A community-based health insurance plan can use data from its provider network and public data sources to support the CDC call to action to identify SARS-CoV-2 vaccinators in the community, including physicians, nurse practitioners, physician assistants, and pharmacies in order to provide macro level estimates of SARS-CoV-2 administration and throughput.
Of city and crowd in 21 century
Authors: Boshnakova Dessislava 
Published: January 2021

Today, many ideas come from the crossing point of different fields. Starting as initiatives in the field of computing, today crowdsourcing can be find in all aspects of human life. In that article, I will focus on the opportunities to use crowdsourcing in the life of a city. This means that using new technologies cities can create initiatives in which to collaborate with its citizens for making the life of the city better. We know that the city is not only buildings and routes. The soul of the city comes from the crowd who lives in that city. Crowdsourcing is just a way to hear the voices of the people and engage them in the future of their city.
Analysis of the Role of Universities in Supporting Sustainable Growth: the Case in Indonesia
Authors: Kurnia Sari Rini , Hidayat Cecep , Bangapadang Stephanie 
Published: January 2021

Indonesia is predicted to experience a demographic bonus period in 2030. In order for Indonesia to get the maximum benefit from this demographic bonus, the availability of abundant productive-age human resources must be balanced by improving the quality of education and skills. Educated and competitive human resources need to be improved in terms of the number and quality of competitiveness to support sustainable growth. In this research, the authors want to see the role of universities in influencing economic growth. The role of universities can be measured by the number of universities, college enrollment rate and the human development index (HDI). The analysis used in this study is multiple linear regression analysis. The research data used are panel data, data from 34 provinces in Indonesia with the study year 2015 - 2018.
A escrita criativa das histórias de vida na formação de professores(as) de francês língua estrangeira
Authors: Costa Wellington Júnio 
Published: January 2021

L’écriture créative a souvent peu d’espace dans le cursus de Lettres au Brésil, bien qu’il s’agisse d’une activité qui favorise le développement de l’écrit par une approche littéraire en même temps que celui de la réflexion sur le processus de formation d’enseignant.e. De 2016 à 2019, nous avons animé, à l’Université Fédérale de Sergipe, des ateliers d’écriture créative auprès des étudiant.e.s en Licence de Lettres Portugais-Français. Avec des objectifs précis établis en amont, soit la participation à des concours littéraires, soit la confection artisanale d’une plaquette bilingue, leurs productions (des poèmes ou des récits courts) se sont montrées comme une expression privilégiée de leurs personnalités, de leurs identités voire de leurs histoires de vie. Cet article a donc pour but de présenter les procédés pédagogiques de ces ateliers, ainsi que quelques réflexions appuyées sur les définitions de l’écrivain de Jean-Paul Sartre (1986), sur les principes pédagogiques de Luiz Antonio de Assis Brasil (2018) et sur les études de Jean-Pierre Cuq et Isabelle Gruca (2018) à propos de la didactique de la production écrite.
Les contradictions des politiques linguistiques brésiliennes et leurs enjeux pour une formation plurilingue et relativiste
Authors: Azevedo Andreia Matias 
Published: January 2021

Cette étude vise à soulever une réflexion sur les politiques linguistiques brésiliennes concernant l’enseignement et l’apprentissage des langues étrangères au cours de l’histoire afin de démontrer que les actions du gouvernement brésilien vont à contre-courant des demandes du contexte politique, économique et social, favorisant ainsi la marche en arrière du pays. D’emblée, cette affirmation part de la nouvelle Base NationaleCommune Curriculaire Brésilienne (BNCC) dans laquelle on remarque que l’anglais est la seule langue étrangère enseignée. Il ne reste aucun doute que l’anglais joue en rôle important dans l’actuel scénario ; pourtant, il serait judicieux également que le système éducatif offre d’autres langues de sorte que les apprenants puissent visionner le monde de différentes perspectives et, par conséquent, développent un sentiment d’altérité, et un regard critique sur l’Autre et Soi-même (LEVINAS, 2014; CARLO, 1998). Un autre point à remarquer touche le développement du pays dans la mesure où cette politique monolinguiste se montre nocive au projet d’internationalisation du système universitaire brésilien.
De l’imitation à la création en langue étrangère: pouvoir être un autre
Authors: Pietraroia Cristina Casadei 
Published: January 2021

Cet article aborde le passage obligatoire, dans l’apprentissage d’une langue étrangère, par le plaisir, le jeu, l’imitation et la création. Le contexte est celui de l’enseignement du français langue étrangère au niveau de la Licence dans une université brésilienne où les étudiants, dont la plupart sont débutants, doivent non seulement apprendre cette langue mais aussi en faire un objet de travail. Il faut donc qu’ils la maîtrisent bien et, pour cela, ils doivent être préparés à mettre en question leurs propres identités et à se montrer dans ce qu’ils ont de plus subjectif : leurs souvenirs et leurs émotions.
Isolasi dan Identifikasi Senyawa Metabolit Sekunder Ekstrak n-Heksana Daun Kayu Jawa (Lannea coromandelica Houtt Merr.)
Authors: Rahayu AM Andi Surya , Salempa Pince , Wijaya Mohammad 
Published: January 2021

ABSTRAK

Penelitian ini adalah penelitian eksplorasi yang bertujuan untuk mengisolasi senyawa metabolit sekunder dalam ekstrak n-heksana Daun Lannea coromandelica Houtt Merr. yang berasal dari kecamatan Cina, kabupaten Bone, Sulawesi Selatan. Isolasi dilakukan dengan beberapa tahap yaitu maserasi, partisi dengan n-heksana, fraksinasi, pemurnian dan identifikasi. Hasil penelitian diperoleh isolat murni berupa kristal jarum berwarna putih dengan titik leleh 140,20C. Hasil uji dengan pereaksi Meyer menghasilkan endapan putih dan Wagner menghasilkan endapan coklat menunjukkan positif alkaloid. Identifikasi dengan spektroskopi infra merah memberikan serapan pada bilangan gelombang (cm-1) : 3502,73 ; 2954,99 ; 2868,15 ; 1687,71; 1463,97; 1382,96; 1330,88; dan 1037,70 yang menunjukkan adanya gugus fungsi -N-H, -C-H alifatik (CH2 dan CH3), -C=O, -C=C, dan -C-N.

Kata kunci : Daun L.coromandelica Houtt Merr., Isolasi, Alkaloid.

ABSTRACT
This study is exploratory research that aims to isolate the secondary metabolite compound contained in n-hexane extract of Lannea coromandelica Houtt Merr. leaves from Cina district, Bone Regency, South Sulawesi. The isolation was done through several stages, maceration, partitioning with n-hexane, fractionation, purification and identification. The results was obtained in pure needle crystal shape with a melting point 140,2°C. The test result with the Meyer reagent showed the formation of a white precipitated and the Wagner test showed the formation of a brown precipitated, there for it can be categorized as positive alkaloid. Identification with an infrared spectroscopy giving absorbance at the wave number (cm-1): 3502,73 ; 2954,99 ; 2868,15 ; 1687,71; 1463,97; 1382,96; 1330,88; and 1037,70 refers of function groups -N-H, -C-H aliphatic (CH2 and CH3), -C=O, -C=C, and -C-N.

Keywords : L.coromandelica Houtt Merr., Leaves, Isolation, Alkaloid.
Rolling Massage PENGARUH PEMBERIAN ROLLING MASSAGE TERHADAP TINGKAT INSOMNIA PADA SANTRIWATI MADRASAH TSANAWIYAH DI PONDOK PESANTREN AL-AMIEN KOTA KEDIRI TAHUN 2019
Authors: Ramayanti Eva dwi 
Published: January 2021

RINGKASAN
Eva Dwi Ramaanti S.Kep Ns.M.Kep Sp.Kep MB1, Wiwin Sulistowati M.Kep
Program Studi Ilmu Keperawatan (S1)
Insomnia adalah ketidakmampuan untuk mencukupi kebutuhan tidur baik kualitas maupun kuantitas. Dari data survey wawancara didapatkan hasil bahwa 8 dari 10 orang mengeluh susah tidur, 9 dari 10 orang mengeluhkan saat siang sering mengantuk, kurang konsentrasi saat pembelajaran, dan sering merasa kurang puas saat tidur. Dari data diatas memberikan informasi bahwa santriwati di Pondok Pesantren Al-Amien sebagian mengalami insomnia. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian rolling massage terhadap tingkat insomnia pada santriwati Madrasah Tsanawiyah di pondok pesantren Al-Amien Kota Kediri. Desain penelitian, yaitu pre eksperimen one goup pre test - post test design. Sampel dalam penelitian ini adalah 15 responden yang diambil dengan menggunakan teknik total sampling. Rolling Massage dilaksanakan 8 kali perlakuan dengan pemeriksaan tingkat insomnia pretest dan posttest. Berdasarkan uji wilcoxon didapatkan p-value 0,01, karena p value < dari ? (0,05) maka H0 ditolak dan H1 diterima yang artinya ada pengaruh pemberian rolling massage terhadap tingkat insomnia pada santriwati Madrasah Tsanawiyah di pondok pesantren Al-Amien Kota Kediri. Hasil penelitian menunjukkan bahwa rolling massage dapat menurunkan tingkat insomnia. Diharapkan dengan penelitian ini santriwati yang mengalami insomnia dapat mengetahui manfaat rolling massage yang dapat menurunkan tingkat insomnia dan dapat meningkatkan kualitas tidurnya. Kesimpulan yang dapat diambil yaitu rolling massage efektif dalam menurunkan tingkat insomnia. Saran penelitian, untuk peneliti selanjutnya dapat menerapkan penelitian lain tentang rolling massage untuk mengurangi tingkat nyeri.
Kata Kunci: Insomnia, Rolling Massage, Tingkat Insomnia
Clinico-Epidemiological Characteristics of Scabies in Children. Do We Need Mass Drug Administration?
Authors: Paudel Vikash , Pradhan Manish , Shah Anil , Chudal Deepa 
Published: January 2021

Introduction: Scabies is contagious neglected parasitic skin infestation a common in children than adults.
Methods: This was cross-sectional retrospective study of scabies diagnosed in children below 5 years of age from January 2019 to June 2019. The clinical and epidemiological characteristics were retrieved, recorded in preformed performa and analyzed using Microsoft excel and SPSS software.
Results: Prevalence of scabies in children was 5.1 %. Among 342 children enrolled, mean age of the children with scabies was 2.4 years. Majority (89.5%) were from rural community and were of lower income. Hindus were three fourth. Clustering of disease was seen in colder months. Common site of involvement due to scabies was abdomen, web-space and genitalia in both male and female. Pruritus was the most common symptom.
Conclusion: Scabies is disease of public health importance with high prevalence and high socio-economic burden in children. To improve the quality of life associated with scabies, there is possibility need of mass drug administration.