bluuebunny/crossref_metadata_2025_split huggingface dataset:
International Consensus on Minimum Preclinical Testing Requirements for the Development of Innovative Therapies For Children and Adolescents with Cancer
Authors: Vassal Gilles , Houghton Peter J. , Pfister Stefan M. , Smith Malcolm A. , Caron Huib N. , Li Xiao-Nan , Shields David J. , Witt Olaf , Molenaar Jan J. , Colombetti Sara , Schüler Julia , Stancato Lou F. 
Published: June 2021

Abstract
Cancer remains the leading cause of disease-related death in children. For the many children who experience relapses of their malignant solid tumors, usually after very intensive first-line therapy, curative treatment options are scarce. Preclinical drug testing to identify promising treatment elements that match the molecular make-up of the tumor is hampered by the fact that (i) molecular genetic data on pediatric solid tumors from relapsed patients and thus our understanding of tumor evolution and therapy resistance are very limited to date and (ii) for many of the high-risk entities, no appropriate and molecularly well-characterized patient-derived models and/or genetic mouse models are currently available. However, recent regulatory changes enacted by the European Medicines Agency (class waiver changes) and the maturation of the RACE for Children act with the FDA, will require a significant increase in preclinical pediatric cancer research and clinical development must occur. We detail the outcome of a pediatric cancer international multistakeholder meeting whose output aims at defining an international consensus on minimum preclinical testing requirements for the development of innovative therapies for children and adolescents with cancer. Recommendations based on the experience of the NCI funded PPTP/C (www.ncipptc.org) and the EU funded ITCC-P4 public private partnership (https://www.itccp4.eu/) are provided for the use of cell-based and mouse models for pediatric solid malignancies, as well as guidance on the scope and content of preclinical proof-of-concept data packages to inform clinical development dependent on clinical urgency. These recommendations can serve as a minimal guidance necessary to jumpstart preclinical pediatric research globally.
A Prototype Analysis of the Cultural and Evolutionary Construction of Romantic Love as a Synthesis of Love and Sex
Authors: de Munck Victor C. , Kronenfeld David B. , Manoharan Christopher 
Published: June 2021

Abstract
Our goal is to use prototype analysis to distinguish the folk or culturally held understandings of love, romantic love, and sex and to specify, from the obtained data, the semantic relationship among these three associated concepts. By considering the semantic distinctions between these three concepts, we come to an unintended insight: if romantic love is a socio-cultural universal it does not appear to have the same evolutionary history as love or sex and this may account for its somewhat ambiguous status in the scholarly literature on romantic love. We demonstrate that, in the United States, sex, in and of itself, is seldom conceived of as a relationship while love and romantic love are primarily viewed as relational. Our findings, though preliminary, strongly suggest that romantic love is a synthesis of two evolutionary drives: love (or bonding) and sex.
Silence Is Not (Always) Golden: A Criticism of the ECJ’s Approach towards Integration Conditions for Family Reunification
Authors: Ganty Sarah 
Published: June 2021

Abstract
Over the past 20 years, integration duties imposed on third-country nationals have spread and become more rigid in EU Member States. They increasingly restrict the conditions for obtaining residence permits as well as the benefit of social rights. These integration conditions take on singular forms and raise particular issues in relation to the Association Agreement concluded between the European Union and Turkey, in particular with regard to so-called ‘standstill clauses’. The present article begins from the A v. Udlændinge-og Integrationsministeriet case and criticises the Court’s silence about the elephant in the room on the issue of integration conditions towards third-country nationals: racial and/or ethnic discrimination. The case is about an integration condition imposed by the Danish Government as a prerequisite for a ‘family reunion’ residence permit for the spouse of a Turkish worker: the spouses must prove that they have a stronger link with Denmark than with Turkey. The solution adopted by the Court of Justice in striking down this integration condition is not surprising. However, its reasoning suggests more tolerance – or even laxity – about the way the concept of integration is used by the Member States. This situation is problematic insofar as these integration conditions, the very principle of which is questionable per se, conceal increasingly discriminatory and exclusionary measures which the Court is reluctant to denounce, as opposed to the European Court of Human Rights.
Beyond the Church and the Poor: Expanding the Subject of Ethnographic Theology
Authors: Grigoni Michael R. 
Published: June 2021

Abstract
The use of ethnography for theological inquiry is no longer novel. Yet, as the introduction to this special issue indicates, the ethnographic turn in Christian theology is animated by distinct postliberal and liberationist trajectories, each with their own theological presumptions and methodological aims. Should the future development of this turn favour one trajectory over another? This paper explores this question in conversation with Todd Whitmore’s Imitating Christ in Magwi: An Anthropological Theology. Through a sustained engagement with Imitating Christ in Magwi, I unearth both postliberal and liberationist inheritances to show that Whitmore’s text exceeds a postliberal-liberationist binary. I then ask what the dual inheritance of his work signifies for the future of the ethnographic turn. Drawing from cultural anthropology’s mode of ‘studying up,’ I suggest that the turn should orient itself more broadly to the care of our common life by expanding attention to subjects with power.
Long-Lead Seasonal Prediction of Streamflow over the Upper Colorado River Basin: The Role of the Pacific Sea Surface Temperature and Beyond
Authors: Zhao Siyu , Fu Rong , Zhuang Yizhou , Wang Gaoyun 
Published: June 2021

AbstractWe have developed two statistical models for extended seasonal predictions of the Upper Colorado River Basin (UCRB) natural streamflow during April–July: a stepwise linear regression (reduced to a simple regression with one predictor) and a neural network model. Monthly, basin-averaged soil moisture, snow water equivalent (SWE), precipitation, and the Pacific sea surface temperature (SST) are selected as potential predictors. Pacific SST Predictors (PSPs) are derived from a dipole pattern over the Pacific (30°S–65°N) that is correlated with the lagging streamflow. For both models, the correlation between the hindcasted and observed streamflow exceeds 0.60 for lead times less than four months using soil moisture, SWE, and precipitation as predictors. This correlation is higher than that of an autoregression model (correlation ~0.50). Since these land-surface and atmospheric variables have no statistically significant correlations with the streamflow, PSPs are then incorporated into the models. The two models have a correlation of ~0.50 using PSPs alone for lead times from six to nine months, and such skills are probably associated with stronger correlation between SST and streamflow in recent decades. The similar prediction skills between the two models suggest a largely linear system between SST and streamflow. Four predictors together can further improve short-lead prediction skills (correlation ~0.80). Therefore, our results confirm the advantage of the Pacific SST information in predicting the UCRB streamflow with a long lead time, and can provide useful climate information for water supply planning and decisions.
Challenges and Opportunities of AI-Enabled Monitoring, Diagnosis & Prognosis: A Review
Authors: Zhao Zhibin , Wu Jingyao , Li Tianfu , Sun Chuang , Yan Ruqiang , Chen Xuefeng 
Published: June 2021

AbstractPrognostics and Health Management (PHM), including monitoring, diagnosis, prognosis, and health management, occupies an increasingly important position in reducing costly breakdowns and avoiding catastrophic accidents in modern industry. With the development of artificial intelligence (AI), especially deep learning (DL) approaches, the application of AI-enabled methods to monitor, diagnose and predict potential equipment malfunctions has gone through tremendous progress with verified success in both academia and industry. However, there is still a gap to cover monitoring, diagnosis, and prognosis based on AI-enabled methods, simultaneously, and the importance of an open source community, including open source datasets and codes, has not been fully emphasized. To fill this gap, this paper provides a systematic overview of the current development, common technologies, open source datasets, codes, and challenges of AI-enabled PHM methods from three aspects of monitoring, diagnosis, and prognosis.
Genomic insights into body size evolution in Carnivora support Peto’s paradox
Authors: Huang Xin , Sun Di , Wu Tianzhen , Liu Xing , Xu Shixia , Yang Guang 
Published: June 2021

AbstractBackgroundThe range of body sizes in Carnivora is unparalleled in any other mammalian order—the heaviest species is 130,000 times heavier than the lightest and the longest species is 50 times longer than the shortest. However, the molecular mechanisms underlying these huge differences in body size have not been explored.ResultsHerein, we performed a comparative genomics analysis of 20 carnivores to explore the evolutionary basis of the order’s great variations in body size. Phylogenetic generalized least squares (PGLS) revealed that 337 genes were significantly related to both head body length and body mass; these genes were defined as body size associated genes (BSAGs). Fourteen positively-related BSAGs were found to be associated with obesity, and three of these were under rapid evolution in the extremely large carnivores, suggesting that these obesity-related BSAGs might have driven the body size expansion in carnivores. Interestingly, 100 BSAGs were statistically significantly enriched in cancer control in carnivores, and 15 of which were found to be under rapid evolution in extremely large carnivores. These results suggested that large carnivores might have evolved an effective mechanism to resist cancer, which could be regarded as molecular evidence to support Peto’s paradox. For small carnivores, we identified 15 rapidly evolving genes and found six genes with fixed amino acid changes that were reported to reduce body size.ConclusionsThis study brings new insights into the molecular mechanisms that drove the diversifying evolution of body size in carnivores, and provides new target genes for exploring the mysteries of body size evolution in mammals.
Transcriptome analysis of embryonic muscle development in Chengkou Mountain Chicken
Authors: Ren Lingtong , Liu Anfang , Wang Qigui , Wang Honggan , Dong Deqiang , Liu Lingbin 
Published: June 2021

Abstract
Background
Muscle is the predominant portion of any meat product, and growth performance and product quality are the core of modern breeding. The embryonic period is highly critical for muscle development, the number, shape and structure of muscle fibers are determined at the embryonic stage. Herein, we performed transcriptome analysis to reveal the law of muscle development in the embryonic stage of Chengkou Mountain Chicken at embryonic days (E) 12, 16, 19, 21.

Results
Diameter and area of muscle fibers exhibited significant difference at different embryonic times(P < 0.01). A total of 16,330 mRNAs transcripts were detected, including 109 novel mRNAs transcripts. By comparing different embryonic muscle development time points, 2,262 in E12vsE16, 5,058 in E12vsE19, 6139 in E12vsE21, 1,282 in E16vsE19, 2,920 in E16vsE21, and 646 in E19vsE21differentially expressed mRNAs were identified. It is worth noting that 7,572 mRNAs were differentially expressed. The time-series expression profile of differentially expressed genes (DEGs) showed that the rising and falling expression trends were significantly enriched. The significant enrichment trends included 3,150 DEGs. GO enrichment analysis provided three significantly enriched categories of significantly enriched differential genes, including 65 cellular components, 88 molecular functions, and 453 biological processes. Through KEGG analysis, we explored the biological metabolic pathways involved in differentially expressed genes. A total of 177 KEGG pathways were enriched, including 19 significant pathways, such as extracellular matrix-receptor interactions. Similarly, numerous pathways related to muscle development were found, including the Wnt signaling pathway (P < 0.05), MAPK signalingpathway, TGF-beta signaling pathway, PI3K-Akt signaling pathway and mTOR signaling pathway. Among the differentially expressed genes, we selected those involved in developing 4-time points; notably, up-regulated genes included MYH1F, SLC25A12, and HADHB, whereas the down-regulated genes included STMN1, VASH2, and TUBAL3.

Conclusions
Our study explored the embryonic muscle development of the Chengkou Mountain Chicken. A large number of DEGs related to muscle development have been identified ,and validation of key genes for embryonic development and preliminary explanation of their role in muscle development. Overall, this study broadened our current understanding of the phenotypic mechanism for myofiber formation and provides valuable information for improving chicken quality.
Multi-ethnic genome-wide association analyses of white blood cell and platelet traits in the Population Architecture using Genomics and Epidemiology (PAGE) study
Authors: Hu Yao , Bien Stephanie A. , Nishimura Katherine K. , Haessler Jeffrey , Hodonsky Chani J. , Baldassari Antoine R. , Highland Heather M. , Wang Zhe , Preuss Michael , Sitlani Colleen M. , Wojcik Genevieve L. , Tao Ran , Graff Mariaelisa , Huckins Laura M. , Sun Quan , Chen Ming-Huei , Mousas Abdou , Auer Paul L. , Lettre Guillaume ,   the Blood Cell Consortium, Tang Weihong , Qi Lihong , Thyagarajan Bharat , Buyske Steve , Fornage Myriam , Hindorff Lucia A. , Li Yun , Lin Danyu , Reiner Alexander P. , North Kari E. , Loos Ruth J. F. , Raffield Laura M. , Peters Ulrike , Avery Christy L. , Kooperberg Charles 
Published: June 2021

Abstract
Background
Circulating white blood cell and platelet traits are clinically linked to various disease outcomes and differ across individuals and ancestry groups. Genetic factors play an important role in determining these traits and many loci have been identified. However, most of these findings were identified in populations of European ancestry (EA), with African Americans (AA), Hispanics/Latinos (HL), and other races/ethnicities being severely underrepresented.

Results
We performed ancestry-combined and ancestry-specific genome-wide association studies (GWAS) for white blood cell and platelet traits in the ancestrally diverse Population Architecture using Genomics and Epidemiology (PAGE) Study, including 16,201 AA, 21,347 HL, and 27,236 EA participants. We identified six novel findings at suggestive significance (P < 5E-8), which need confirmation, and independent signals at six previously established regions at genome-wide significance (P < 2E-9). We confirmed multiple previously reported genome-wide significant variants in the single variant association analysis and multiple genes using PrediXcan. Evaluation of loci reported from a Euro-centric GWAS indicated attenuation of effect estimates in AA and HL compared to EA populations.

Conclusions
Our results highlighted the potential to identify ancestry-specific and ancestry-agnostic variants in participants with diverse backgrounds and advocate for continued efforts in improving inclusion of racially/ethnically diverse populations in genetic association studies for complex traits.
PINIR: a comprehensive information resource for Pin-II type protease inhibitors
Authors: Yadav Nikhilesh K. , Saikhedkar Nidhi S. , Giri Ashok P. 
Published: June 2021

Abstract
Background
Serine protease inhibitors belonging to the Potato type-II Inhibitor family Protease Inhibitors (Pin-II type PIs) are essential plant defense molecules. They are characterized by multiple inhibitory repeat domains, conserved disulfide bond pattern, and a tripeptide reactive center loop. These features of Pin-II type PIs make them potential molecules for protein engineering and designing inhibitors for agricultural and therapeutic applications. However, the diversity in these PIs remains unexplored due to the lack of annotated protein sequences and their functional attributes in the available databases.

Results
We have developed a database, PINIR (Pin-II type PIs Information Resource), by systematic collection and manual annotation of 415 Pin-II type PI protein sequences. For each PI, the number and position for signature sequences are specified: 695 domains, 75 linkers, 63 reactive center loops, and 10 disulfide bond patterns are identified and mapped. Database analysis revealed novel subcategories of PIs, species-correlated occurrence of inhibitory domains, reactive center loops, and disulfide bond patterns. By analyzing linker regions, we predict that alternative processing at linker regions could generate PI variants in the Solanaceae family.

Conclusion
PINIR (https://pinir.ncl.res.in) provides a web interface for browsing and analyzing the protein sequences of Pin-II type PIs. Information about signature sequences, spatio-temporal expression, biochemical properties, gene sequences, and literature references are provided. Analysis of PINIR depicts conserved species-specific features of Pin-II type PI protein sequences. Diversity in the sequence of inhibitory domains and reactive loops directs potential applications to engineer Pin-II type PIs. The PINIR database will serve as a comprehensive information resource for further research into Pin-II type PIs.
Association between successful aging transitions and depressive symptoms among older Korean adults: findings from the Korean longitudinal study of aging (2006–2018)
Authors: Nari Fatima , Jang Bich Na , Kim Selin , Jeong Wonjeong , Jang Sung-In , Park Eun-Cheol 
Published: June 2021

Abstract
Background
The importance of SA (Successful aging) has been emphasized in recent years, with focus shifting towards attaining healthier aging rather than longevity. However, the influence of SA and its changes on mental health such as depression remains a relatively unexplored area in gerontology. Therefore, we investigated the longitudinal association between changes in SA and depressive symptoms in Korean older adults.

Methods
This study comprised a longitudinal sample of older adults aged ≥ 45 years, drawn from the Korean Longitudinal Study of Aging (2006–2018). Changes in SA status was determined using the Rowe and Kahn model over two consecutive years. Using an adjusted generalized estimating equation model, we examined the association between changes in successful aging status, namely SA and NSA (Non-successful aging), and depressive symptoms.

Results
Compared to the SA→SA group, depressive symptom risk in the NSA→NSA and SA→NSA groups were higher in men [(OR, 1.16; 95 % CI, 1.13–1.18), (OR, 1.11; 95 % CI, 1.08–1.13), respectively] and in women [(OR, 1.15; 95 % CI, 1.13–1.18), (OR, 1.11; 95 % CI, 1.09–1.14), respectively]. Subgroup analysis of the dimensions of successful aging revealed that low or worsening criteria of successful aging status in men and women were associated with depressive symptoms.

Conclusions
Korean older adults who continuously failed to attain or maintain successful aging status had the highest risk of depressive symptoms. These results could further assist in establishing policies and interventions that promote successful aging and subsequently protect the mental health of the Korean older adult population.
Barriers and facilitators to the implementation of social robots for older adults and people with dementia: a scoping review
Authors: Koh Wei Qi , Felding Simone Anna , Budak Kübra Beliz , Toomey Elaine , Casey Dympna 
Published: June 2021

Abstract
Background
Psychosocial issues, such as social isolation and loneliness among older adults and people with dementia, continue to pose challenges with a rapidly aging population worldwide. Social robots are a rapidly emerging field of technology, developed to help address the psychosocial needs of this population. Although studies have reported positive findings regarding their psychosocial benefits, their implementation in real-world practice remains a challenge. Nevertheless, little is known about the factors affecting their implementation. The purpose of this review is to provide a systematic overview of the barriers and facilitators affecting the implementation of social robots for older adults and people with dementia.

Method
The Arksey and O’Malley approach with methodological enhancement by Levac et al. was used to guide the conduct of this review. Seven electronic databases were searched. In addition, hand searching and backward citation tracing was conducted. Three independent reviewers were involved in the screening and data charting process. Findings were synthesised and categorised into the five domains outlined in the Consolidated Framework of Implementation Research (CFIR).

Results
A total of 53 studies were included in the final review. Most of the included studies were based in participants’ homes and in care facilities. Barriers and facilitators were mapped onto 18 constructs in the five domains of the CFIR. The most frequently cited barriers were mapped to the constructs within the domain of “Intervention characteristics”, where issues such as the complexity of using the technology and technical obstacles impeded implementation. Most facilitators were mapped onto the domain “Patient needs and resources”. Overall, existing research are disproportionately focused on the internal validity (i.e. characteristics) of social robots, and there is significantly less research investigating their external validity, such as organisational or wider contextual factors that can affect their implementation in real-world practice.

Conclusion
This review has identified and synthesised the breadth of evidence on the barriers and facilitators to the implementation of social robots for older adults and people with dementia. Future research should pay more attention to investigating the contextual factors, using an implementation framework, to identify barriers and facilitators to guide the implementation of social robots.