bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyunsaturated fatty acid status and risk of type 1 diabetes in infants and children: a systematic review and meta-analysis
Authors: Wang Xingmu , Zhong Shuping , Dong Jingfen , Zhuge Fuyuan 
Published: March 2021

IntroductionThe existing findings about the association between polyunsaturated fatty acid (PUFA) status (especially long-chain n-3 PUFAs) and the risk of preclinical or clinical type 1 diabetes (T1D) in children are controversial. This review aimed to evaluate the definite association.Material and methodsThree databases were systematically viewed until July, 2019 to identify relevant articles, without language restriction. Any observational study or randomized controlled trial reporting the risk estimates of preclinical or clinical T1D for PUFA status in infants and children was enrolled. Regardless of the statistical heterogeneity assessed by the I2 statistic, we pooled the odds ratios (ORs), relative risks (RRs) or hazard ratios (HRs) with 95% confidence intervals (CI) through random-effects models.ResultsFive observational studies were enrolled in the meta-analysis. The status of n-3 PUFAs was negatively and significantly associated with the risk of preclinical, but not clinical, T1D (pooled RR = 0.85; 95% CI: 0.73–0.99) with substantial heterogeneity (I<sup>2</sup> = 72.2%). However, no such association was found between n-6 PUFA status and the risk of preclinical or clinical T1D.ConclusionsThe meta-analysis suggests that n-3 PUFA might play a potential protective role in the cause of preclinical T1D, and n-3 PUFA intake may be beneficial, since the n-3 PUFA status was associated with a significant decrease in the risk of preclinical T1D in children. Nevertheless, more well-designed prospective studies are necessary to determine whether dietary or supplemental intake of specific n-3 PUFA alters the risk of preclinical T1D.
Quality of life, anxiety and depressive disorders in patients with extrasystolic arrhythmia
Authors: Mikhaylov Alexey Y. , Yumashev Alexei V. , Kolpak Eugeny 
Published: March 2021

IntroductionThe aim of this study was to perform a comparative and economic analysis of the degree of development of anxiety-depressive disorder in patients with different types of extrasystolic arrhythmia using different assessment scales.Material and methodsThe study was conducted in 2018–2019 at the premises of clinic No. 4, involving 450 patients (Moscow, Russia). Patients were divided into three groups: with coronary heart disease (CHD) (147 patients), with myocardiodystrophy (MCD) (113) and with cardiopsychoneurosis (CPN) (190). Everyone underwent round-the-clock electrocardiography (ECG) and echocardiography. If symptoms of depressive disorder are detected in a timely manner, the risk of adverse cardiovascular diseases may be reduced.ResultsDepression and anxiety indicators on all three scales differed significantly (p ≤ 0.05) in patients with supraventricular extrasystole (more than 40 points on the Zung scale, 14 points on the Montgomery-Asberg depression scale, more than 38 points on Zung and 3 points on Covi anxiety scales). For patients with ventricular extrasystole, a significant difference was established between groups 1 and 2 only in terms of the level of depression on the Zung scale. Factors of psychogenic origin determine the development of cardiac rhythm disturbances.ConclusionsThe study showed that for supraventricular extrasystoles, these factors determine the overall health of the patient. The differences between the three groups are significant on all scales of depression and anxiety (p ≤ 0.05). The most susceptible to depression and anxiety are patients with extrasystolic arrhythmias diagnosed with CHD, as well as MCD.
The effect of therapeutic exercise in the prevention
of lymphoedema secondary to breast cancer:
a systematic review
Authors: Tendero-Ruiz Laura , Palomo-Carrión Rocío , Megía-García-Carpintero Álvaro , Pérez-Nombela Soraya , López-Muñoz Purificación , Bravo-Esteban Elisabeth 
Published: March 2021

IntroductionOne of the most frequent complications of breast cancer treatment is lymphoedema (LE), with lymphadenectomy and radiotherapy being the main triggers of this pathology in developed countries. The aim of the study was to determine the efficacy of therapeutic exercise in the prevention of upper limb (UL) lymphoedema evaluated through cirtometry, volumetry, or bioimpedance spectroscopy (BIS) in women after breast cancer removal surgery.Material and methodsThe Pubmed, PEDro, and Cochrane databases were consulted up to May 2020, including randomised clinical trials (RCTs) on therapeutic physical exercise as a possible preventive measure against breast cancer-related lymphoedema (BCRL). The studies were requested to have participants with UL lymphoedema and a control group.ResultsA total of 304 articles were found, of which 9 were included (stand-alone studies). A therapeutic exercise program (strength and/or aerobic training) in women who had been surgically intervened for breast cancer may prevent lymphedema, compared to a regular care.ConclusionsA therapeutic exercise program (strength and/or aerobic training) in women operated on for breast cancer contributes to reducing the number of cases that could obtain a greater difference in volume in their upper limbs, compared to a regular care program. However, further research is necessary to affirm that therapeutic physical exercise prevents BCRL.
Efficacy and harms of convalescent plasma for treatment of hospitalized COVID-19 patients: a systematic review and meta-analysis
Authors: Piscoya Alejandro , Ng-Sueng Luis , Parra del Riego Angela , Cerna-Viacava Renato , Pasupuleti Vinay , Thota Priyaleela , Roman Yuani , Hernandez Adrian 
Published: March 2021

IntroductionWe systematically reviewed benefits and harms of convalescent plasma (CP) in hospitalized COVID-19 patients.Material and methodsRandomized controlled trials (RCTs) and observational studies assessing CP effects on hospitalized, adult COVID-19 patients were searched until November 24, 2020. We assessed risk of bias (RoB) using Cochrane RoB 2.0 and ROBINS-I tools. Inverse variance random effect meta-analyses were performed. Quality of evidence was evaluated using GRADE methodology. Primary outcomes were all-cause mortality, clinical improvement, and adverse events.ResultsFive RCTs (n = 1067) and 6 cohorts (n = 881) were included. Three and 1 RCTs had some concerns and high RoB, respectively; and there was serious RoB in all cohorts. Convalescent plasma did not reduce all-cause mortality in RCTs of severe (RR = 0.60, 95% CI: 0.33–1.10) or moderate (RR = 0.60, 95% CI: 0.09–3.86) COVID-19 vs. standard of care (SOC); CP reduced all-cause mortality vs. SOC in cohorts (RR = 0.66, 95% CI: 0.49–0.91). Convalescent plasma did not reduce invasive ventilation vs. SOC in moderate disease (RR = 0.85, 95% CI: 0.47–1.55). In comparison to placebo + SOC, CP did not affect all-cause mortality (RR = 0.75, 95% CI: 0.48–1.16) or clinical improvement (HR = 1.07, 95% CI: 0.82–1.40) in severe patients. Adverse and serious adverse events were scarce, similar between CP and controls. Quality of evidence was low or very low for most outcomes.ConclusionsIn comparison to SOC or placebo + SOC, CP did not reduce all-cause mortality in RCTs of hospitalized COVID-19 patients. Convalescent plasma did not have an effect on other clinical or safety outcomes. Until now there is no good quality evidence to recommend CP for hospitalized COVID-19 patients.
Measurement report: Chemical characteristics of PM2.5 during typical biomass burning season at an agricultural site of the North China Plain
Authors: Liang Linlin , Engling Guenter , Liu Chang , Xu Wanyun , Liu Xuyan , Cheng Yuan , Du Zhenyu , Zhang Gen , Sun Junying , Zhang Xiaoye 
Published: March 2021

Abstract. Biomass burning activities are ubiquitous in China, especially in northern China,
where there is a large rural population and winter heating
custom. Biomass burning tracers (i.e., levoglucosan, mannosan and potassium
(K+)), as well as other chemical components, were quantified at a rural
site (Gucheng, GC) in northern China from 15 October to 30 November, during a
transition heating season, when the field burning of agricultural residue
was becoming intense. The measured daily average concentrations of
levoglucosan, mannosan and K+ in PM2.5 (particulate
matter with aerodynamic diameters less than 2.5 µm) during this study were
0.79 ± 0.75, 0.03 ± 0.03 and 1.52 ± 0.62 µg m−3, respectively. Carbonaceous components and
biomass burning tracers showed higher levels during nighttime than daytime,
while secondary inorganic ions were enhanced during daytime. An episode with
high levels of biomass burning tracers was encountered at the end of
October 2016, with high levoglucosan at 4.37 µg m−3. Based on
the comparison of chemical components during different biomass burning
pollution periods, it appeared that biomass combustion can obviously elevate
carbonaceous component levels, whereas there was essentially no effect on secondary
inorganic aerosols in the ambient air. Moreover, the levoglucosan / mannosan
ratios during different biomass burning pollution periods remained at high
values (in the range of 18.3–24.9); however, the levoglucosan / K+
ratio was significantly elevated during the intensive biomass burning
pollution period (1.67) when air temperatures were decreasing, which was substantially
higher than in other biomass burning periods (averaged at 0.47).
Faktor-Faktor yang Berhubungan dengan Kejadian Diabetes Mellitus di UPTD Diabetes Center Kota Ternate Tahun 2018
Authors: Wadja Helena , Rahman Hamidah , Supriyatni Nani 
Published: March 2021

Diabetes adalah penyakit yang berlangsung lama atau kronis serta ditandai dengan kadar gula (glukosa) darah yang tinggi atau di atas nilai normal. Glukosa yang menumpuk di dalam darah akibat tidak diserap sel tubuh dengan baik dapat menimbulkan berbagai gangguan organ tubuh. Diabetes melitus (DM) menjadi ancaman serius bagi kesehatan manusia pada abad ke-21. Jumlah penderita DM mencapai 422 juta orang di dunia pada tahun 2014. Sebagian besar dari penderita tersebut berada di negara berkembang. Indonesia sebagai salah satu negara berkembang memiliki jumlah penderita yang cukup tinggi. Tujuan penelitian ini adalah untuk mengetahui hubungan tingkat pengetahuan, tingkat stres, dan durasi tidur terhadap kejadian Diabetes Mellitus. Metode penelitian dengan menggunakan desain cross sectional study. Populasi dalam penelitian ini adalah pasien yang datang memeriksakan kadar gula darah di UPTD Diabetes Center Kota Ternate Tahun 2018. Jumlah sampel 95 orang yang diambil dengan cara accidental sampling. Hasil uji statistik dengan menggunakan uji chi square menunjukkan bahwa faktor-faktor yang berhubungan dengan penyakit Diabetes Mellitus adalah tingkat stres dengan p-value = 0,037 ( <0,1 ) dan durasi tidur dengan p-value = 0,025 ( <0,1 ), sedangkan yang tidak berhubungan adalah tingkat pengetahuan dengan p-value = 0,709 ( >0,1 ). Oleh karena itu, disarankan kepada petugas kesehatan lebih meningkkatkan lagi informasi kepada masyarakat tentang penyakit Diabetes Mellitus, agar masyarakat lebih tahu tentang penyakit Diabetes Mellitus.
Penyelesaian Pembagian Harta Bersama Melalui Mediasi Di Pengadilan Negeri Kelas IA Palu
Authors: Maisa Maisa 
Published: March 2021

Tujuan penelitjan menganalisis penyelesaian pembagian harta bersama melalui Mediasi di Pengadilan Negeri Kelas IA Palu dan Apa sajakah hambatan-hambatan dalam pelaksanaan mediasi dalam perkara pembagian harta bersama di Pengadilan Negeri Kelas IA Palu. Metode penelitian yang digunakan adalah metode penelitian normatif. Hasil penelitian menunjukkan bahwa Mekanisme penyelesaian pembagian harta gono gini melalui Mediasi di Pengadilan Negeri Kelas IA Palu bahwa setiap perkara yang telah ditunjuk majelis hakim memeriksa perkara terlebih dahulu, kemudian ditempuh mediasi dengan menunjuk mediator oleh majelis hakim. Selanjutnya mediator sebagai fasilitator menetapkan waktu pertemuan untuk melakukan mediasi, artinya dalam proses mediasi mediator berperan membantu/menengahi agar kesepakatan antara para pihak tentang pembagian harta bersama dapat terwujud atas dasar musyawarah. Selanjutnya jika kesepaktan terwujud, maka dibuat akta perdamaian yang dibantu oleh mediator dalam tinjauan yuridisnya. Kemudian dengan laporan mediator, perkara kembali kepada majelis hakim untuk menyikapi akta perdamaian dan Hambatan-hambatan dalam pelaksanaan mediasi dalam perkara pembagian harta gono gini di Pengadilan Negeri Kelas I A Palu adalah ketidakhadiran salah satu para pihak, Kuasa Hukum para pihak yang kurang maksimal memberikan penjelasan mengenai manfaat mediasi dan adanya ego yang berlebihan dari masing-masing pihak.
The research objective to analyze the settlement of the distribution of joint assets through Mediation at the Palu IA Class District Court and what are the obstacles in the implementation of mediation in the case of sharing assets together in the Class IA Palu District Court. The research method used is normative research method. The results showed that the settlement mechanism for the distribution of assets gono gini through Mediation in the Class IA Palu District Court that every case that has been appointed by the panel of judges examines the case first, then goes through mediation by appointing a mediator by the panel of judges. Furthermore, the mediator as the facilitator determines the meeting time to conduct mediation, meaning that in the mediation process the mediator plays a role in assisting / mediating so that the agreement between the parties regarding the sharing of collective assets can be realized on the basis of deliberation. Furthermore, if the agreement is realized, a peace deed will be drawn up which is assisted by the mediator in his juridical review. Then with the mediator's report, the case returned to the panel of judges to address the peace deed and Obstacles in the implementation of mediation in the case of distributing assets at the IA Class District Court in Palu was the absence of one of the parties, the legal counsel of the parties who were not maximal in providing an explanation regarding the benefits of mediation and the excessive ego of each party.
Efektivitas Kejaksaan Dalam Pengembalian Kerugian Negara Akibat Tindak Pidana Korupsi
Authors: Siswandi Siswandi , Sampara Said , Badaru Baharuddin 
Published: March 2021

Penelitian bertujuan untuk mengetahui efektivitas kejaksaan dalam upaya pengembalian kerugian negara akibat tindak pidana korupsi, dan faktor yang menghambat kejaksaan dalam upaya pengembalian kerugian negara akibat tindak pidana korupsi.Tipe penelitian ini adalah yuridis empiris. Hasil Penelitian penulis mendapatkan bahwa: Efektivitas kejaksaan dalam upaya pengembalian kerugian negara akibat tindak pidana korupsi belum efektif. Hal ini dikarenakan dalam penegakan hukum terhadap pelaku tindak pidana korupsi dalam rangka pengembalian kerugian negara ditemukan hambatan yakni, hambatan kultural bersumber dari kebiasaan negatif yang berkembang di masyarakat serta hambatan instrumental dalam bentuk peraturan perundang-undangan yang membuat penanganan tindak pidana korupsi tidak berjalan sebagaimana mestinya. Hukuman yang diterapkan hanya sebatas hukuman badan dan pengembalian kerugian negara sehingga tidak membuat pelaku tindak pidana korupsi tidak berkurang. Faktor yang menghambat kejaksaan dalam upaya pengembalian kerugian negara akibat tindak pidana korupsi antara lain: Minimnya saksi yang mendukung pembuktian perkara korupsi, Keterbatasan sarana dan prasarana, Penghitungan kerugian negara.
This study aims to determine the effectiveness of the prosecutor's office in an effort to recover state losses due to corruption, and the factors that hinder the prosecutor's office in trying to recover state losses due to corruption. The type of this research is juridical empirical. The results of the authors' research found that: The effectiveness of the prosecutor's office in recovering state losses due to corruption has not been effective. This is because in law enforcement against perpetrators of criminal acts of corruption in the context of recovering state losses, obstacles are found, namely, cultural barriers that arise from negative habits that develop in society as well as instrumental obstacles in the form of laws and regulations that make the handling of corruption crimes not run properly. The punishments that are applied are limited to corporal punishment and the return of state losses so that it does not reduce the perpetrators of corruption. Factors that hinder the prosecutor's office in efforts to recover state losses due to criminal acts of corruption include: The lack of witnesses who support proof of corruption cases, Limited facilities and infrastructure, Calculation of state losses.
Efektivitas Penyidikan Tindak Pidana Korupsi Di Bidang Pengadaan Barang Dan Jasa Oleh Polres Bulukumba
Authors: Nasir Anas Wahyudi , Pawennei Mulyati , Yunus Ahyuni 
Published: March 2021

Tujuan penelitian menganalisis efektivitas penyidikan tindak pidana korupsi di bidang pengadaan barang dan jasa oleh Polres Bulukumba. Penelitian ini adalah penelitian hukum empiris, yakni penelitian yang dilakukan langsung di lapangan. Data yang diperoleh baik primer maupun sekunder dianalisis baik secara deduktif maupun induktif kemudian disajikan secara deskriptif. Hasil penelitian menunjukkan bahwa Efektivtas Penyidikan tindak pidana korupsi di bidang pengadaan barang dan jasa oleh Polres Bulukumba adalah melalui upaya penyidikan melalui teknik pengembangan kasus dengan memanfaatkan saksi pelapor dan saksi pelaku serta teknik audit investigatif sebagai metode pencarian dan pengumpulan data, informasi dan temuan lainnya untuk mengetahui kebenaran atau bahkan kesalahan sebuah fakta dengan berkoordinasi dengan BPK/BPKP. Faktor yang menghambat dalam penyidikan tindak pidana korupsi di bidang pengadaan barang dan Jasa adalah keterbatasan jumlah sumber daya manusia pada Penyidik Polri yang melakukan kegiatan Penyelidikan dan Penyidikan serta keterbatasan sumber dana/anggaran penanganan perkara dalam kegiatan penyidikan.
The research objective was to analyze the effectiveness of the investigation of corruption in the procurement of goods and services by the Bulukumba Police. This research is an empirical legal research, which is research conducted directly in the field. The data obtained both primary and secondary were analyzed both deductively and inductively then presented descriptively. The results show that the effectiveness of investigating corruption in the procurement of goods and services by the Bulukumba Police is through investigative efforts through case development techniques using reporting witnesses and perpetrator witnesses and investigative audit techniques as a method of searching and collecting data, information and other findings to determine truth or even error of a fact in coordination with the BPK / BPKP. Factors that hinder the investigation of criminal acts of corruption in the field of goods and services procurement are the limited number of human resources for Polri Investigators who carry out Investigation and Investigation activities as well as limited funding sources / budget for case handling in investigation activities.
Pengaruh Kualitas Layanan Terhadap Kepuasan dan Loyalitas Nasabah Pada PT Bank Negara Indonesia (Persero) Tbk Unit Siwa Kabupaten Wajo
Authors: Islam Muh. Syaiful , Hamzah Nasir , Mahmud Amir 
Published: March 2021

Tujuan penelitian ini adalah untuk menganalisis pengaruh kualitas layanan melalui (Tangible, Reliability, Responsiveness, assurance, Emphaty) terhadap kepuasan nasabah. Untuk menganalisis pengaruh layanan melalui Tangible, Reliability, Responsiveness, assurance, Emphaty) terhadap loyalitas nasabah. Untuk menganalisis pengaruh kepuasan nasabah terhadap loyalitas. Untuk menganalisis kualitas layanan (Tangible, Reliability, Responsiveness, assurance, Emphaty) melalui kepuasan nasabah pada PT Bank Negara Indonesia (Persero), Tbk Unit Siwa Kabupaten Wajo. Untuk mengimplemasikan tujuan tersebut maka digunakan analisis deskriptif, uji validitas dan uji reliabilitas, uji asumsi klasik, analisis jalur. Hasil penelitian menemukan bahwa kualitas layanan melalui bukti fisik, kehandalan, daya tanggap, jaminan dan empati berpengaruh postif dan signifikan terhadap kepuasan nasabah. Kualitas layanan melalui bukti fisik, kehandalan, daya tanggap, jaminan dan empati berpengaruh positif dan signifikan terhadap loyalitas nasabah. Hasil uji mediasi yang menunjukkan bahwa kepuasan nasabah tidak dapat memediasi pengaruh kualitas pelayanan melalui bukti fisik, kehandalan, daya tanggap, jaminan dan empati terhadap loyalitas nasabah pada PT Bank Negara Indonesia (Persero), Tbk Unit Siwa Kabupaten Wajo.
The purpose of this study is to analyze the effect of service quality through (Tangible, Reliability, Responsiveness, Assurance, Emphaty) on customer satisfaction. To analyze the influence of services through Tangible, Reliability, Responsiveness, assurance, Emphaty) on customer loyalty. To analyze the effect of customer satisfaction on loyalty. To analyze service quality (Tangible, Reliability, Responsiveness, assurance, Emphaty) through customer satisfaction at PT Bank Negara Indonesia (Persero), Tbk. Siwa Unit in Wajo Regency. To implement these objectives, descriptive analysis, validity test and reliability test, classic assumption test, path analysis are used. The results of the study found that service quality through physical evidence, reliability, responsiveness, assurance and empathy had a positive and significant effect on customer satisfaction. Quality of service through tangible, reliability, responsiveness, assurance and empathy has a positive and significant effect on customer loyalty. The mediation test results show that customer satisfaction cannot mediate the effect of service quality through tangible, reliability, responsiveness, assurance and empathy for customer loyalty at PT Bank Negara Indonesia (Persero), Tbk. Siwa Unit in Wajo Regency.
Pengaruh kualitas Layanan Dan Kualitas Produk Terhadap Kepuasan Pelanggan
Authors: Novia Mirna Ayu , Semmaila Baharuddin , Imaduddin Imaduddin 
Published: March 2021

Tujuan penelitian ini adalah untuk mengetahui pengaruh kualitas layanan melalui (Tangible, Reliability, Responsiveness, assurance, Emphaty) terhadap kepuasan pelanggan. Untuk mengetahui pengaruh kualitas produk melalui (fungsi, fitur, keandalan, kesesuaian, usia produk, estetika, perceived, quality) terhadap kepuasan pelanggan. Untuk mengimplementasikan tujuan tersebut maka digunakan analisis deskriptip. uji asumsi klasik, uji validitas dan uji reliabilitas. Hasil penelitian menemukan bahwa kualitas layanan melalui bukti fisik, kehandalan, daya tanggap, jaminan dan empati berpengaruh postif dan signifikan terhadap kepuasan pelanggan. Kualitas produk melalui fungsi, fitur, keandalan, kesesuaian, usia produk, estetika, perceived, quality berpengaruh positif dan signifikan terhadap kepuasan pelanggan . dari kedua variabel bebas yang digunakan dalam menetukan tingkat kepuasan pelanggan, ternyata variabel kualitas produk yang mempunyai pengaruh dominan dalam meningkatkan kepuasan pelanggan pada Toko Novia di Pusat Grosir Butung Makassar.
The purpose of this research is to find out the effect of quality of service through (Tangible, Reliability, Responsiveness, assurance, Emphaty) on customer satisfaction. To know the effect of product quality through (functionality, features, reliability, suitability, product age, aesthetics, perceived, quality) on customer satisfaction. To implement these objectives, descriptive analysis is used. classic assumption test, validity test and reliability test. The results found that the quality of service through physical evidence, reliability, responsiveness, assurance and empathy had a significant effect on customer satisfaction. Product quality through functionality, features, reliability, suitability, product age, aesthetics, perceived, quality has a positive and significant effect on customer satisfaction. of the two free variables used in improving customer satisfaction levels, it turns out that product quality variables have a dominant influence in improving customer satisfaction at Novia Store in Butung Makassar Wholesale Center.