bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacto da internacionalização na carreira de pesquisadores brasileiros
Authors: Garcia Deomara Cristina Damasceno , Garcia Valdir 
Published: October 2021

Este estudo objetivou analisar as transformações nas carreiras profissionais dos pesquisadores brasileiros no campo acadêmico nacional após o processo de internacionalização. Foi iniciado na École de Hautes Études en Sciences Sociales (EHESS), em Paris (França), em 2005. A pesquisa abrangeu questionários e entrevistas com 14 pesquisadores brasileiros bolsistas e análises dos currículos via Plataforma Lattes/CNPq, e trata-se de um estudo longitudinal, sendo levantadas informações para identificar a evolução da produção acadêmica e a inserção internacional. Os resultados corroboraram a hipótese de que o processo de internacionalização trouxe transformações positivas de oportunidades nas carreiras dos pesquisadores brasileiros entrevistados, repercutiu em trunfos e distinção, melhor inserção na academia e na produção de conhecimento, atuação em novos cargos acadêmicos e significativo aumento da produção científica no campo acadêmico nacional, mesmo que de forma diferenciada quanto às posições dos pesquisadores quanto ao engajamento no campo acadêmico, sejam eles “mais consolidados” ou “menos consolidados”.
Pituitary spindle cell oncocytoma: illustrative case
Authors: Taka Taha M. , Yang Chen Yi , Limbo Joshua N. , Chan Alvin Y. , Davies Jordan , Kuan Edward C. , Turner Scott G. , Hsu Frank P. K. 
Published: October 2021

BACKGROUND
Spindle cell oncocytoma (SCO) of the pituitary gland is an extremely rare nonfunctional World Health Organization grade I tumor. SCOs are often misdiagnosed as nonfunctional pituitary adenomas on the basis of preoperative imaging. They are often hypervascular and locally adherent, which increases hemorrhage risk and limits resection, leading to increased risk of recurrence. The authors report a case of SCO treated at their institution and provide a review of the current literature.

OBSERVATIONS
SCO of the pituitary gland can be a rare cause of progressively growing pituitary tumors that presents similarly to nonfunctional pituitary adenoma. Endoscopic transsphenoidal resection of the tumor by a multidisciplinary team allowed total resection despite local adherence of the tumor. Postoperatively, the patient’s visual symptoms improved with persistence of secondary adrenal insufficiency and secondary hypothyroidism.

LESSONS
Careful resection is needed due to SCO’s characteristic hypervascularity and strong adherence to minimize local structure damage. Long-term follow-up is recommended due to the tendency for recurrence.
Early motor development in infants with moderate or severe bronchopulmonary dysplasia
Authors: DeMauro S.B. , Burkhardt M. , Wood A. , Nilan K. , Jensen E.A. , Bamat N.A. , Zhang H. , Gibbs K. 
Published: October 2021

BACKGROUND: Timely development of early motor skills is essential for later skill development in multiple domains. Infants with severe bronchopulmonary dysplasia (BPD) have significant risk for developmental delays. Early motor skill development in this population has not been described. The aim of the present study was to characterize motor skill acquisition at 3 and 6 months corrected age (CA) and assess trajectories of skill development over this time period in infants with severe BPD. METHODS: We performed a single-center, retrospective descriptive study. Motor skills were categorized as present and normal, present but atypical, or absent at 3 and 6 months CA. Logistic regression was used to identify clinical characteristics associated with negative trajectories of skill acquisition. RESULTS: Data were available for 232 infants and 187 infants at 3 and 6 months CA, respectively. Ten motor skills were present and normal in 5–44%(range) of subjects at 3 months. Nineteen motor skills were present and normal in 1–63%(range) of subjects at 6 months. Significant postural asymmetry was noted throughout the study period. Loss of skills and worsening asymmetries over time were common. Exposure to sedating medications was significantly associated with poor development. CONCLUSION: We report delays in motor skill acquisition and postural asymmetries in infants with severe BPD at both 3 and 6 months CA. The association between sedating medications and poor development suggests that efforts to limit these exposures may lead to improved development. Targeted interventions to facilitate early motor development may improve outcomes of this high-risk population.
Nitrate Adsorption by Activated Carbon
Authors: Rosenblum Adam 
Published: October 2021

Activated carbon is a type of carbon that is a known catalyst for a variety of chemical reactions. Uses of activated carbon include purifying liquids and gases, food and beverage processing, odor removal, industrial pollution control, and numerous other applications. There are a variety of different activated carbons, with most being derived from coal, peat, and wood. Activated carbon is a catalyst because the small pores of the carbon increase the surface area available for adsorption or chemical reactions. One primary use of activated carbon is how it adsorbs nitrates onto its surface. This paper delves into different adsorption rates of an activated carbon (Filtrasorb 600) that is treated with different chemicals and then subjected to a chemical activation at a constant pressure under different gaseous conditions. Data collected during experiments indicate there are significant interactions between surface functional groups and nitrate.
Keywords: activated carbon, adsorption, nitrates
Counterterrorism and Immigration in Hungary
Authors: Berman Phoenix Skylar 
Published: October 2021

The European migration crisis beginning in 2014 served as a turning point in Hungarian politics where immigration issues effectively altered the nation’s security environment. The migratory routes as a pathway for illegal border crossings positioned Hungary on the frontline as a transit country for migrants seeking asylum in Western Europe. A critical analysis of Orbán's rhetoric and Hungary’s behavior in the realm of immigration and counterterrorism (CT) policy during and after the immigration crisis is relevant in understanding the state’s security environment. Anti-immigrant sentiments reflected in the population and Prime Minister Viktor Orbán's rhetoric aims to tie refugee migration to terrorist acitvity. Migrants were targeted as a risk to the traditional European identity and survival of the state with a specific emphasis on Muslim migration from the Middle East and North Africa. This study seeks to understand Hungary’s regional and global security role and how CT activity is used by the government to legitimize government actions, particularly on immigration via securitization theory from the Copenhagen School. Hungary has heightened its role on the international stage through transnational CT cooperation and capitalized on anti-immigrant sentiments through speech acts to further exercise its influence in border control and the international fight against global terrorism. By examining a total of 36 speeches presented by Orbán from 2015 to 2020, the study is able to examine how immigration issues were securitized to develop pathways for extraordinary actions and authoritarian reforms performed by securitizing actors.
Who Owns Space?
Authors: O'Brien Nathan William 
Published: October 2021

Space mining is no longer a figment of fringe science fiction. Due to the recent passage of the Space Resource Exploration and Utilization Act of 2015 (SREU Act), U.S. domestic space companies now have a semblance of legislative backing to launch commercial resource acquisition ventures in space. Previously, such companies floundered as capital from investors was reasonably sparse. Uncertainty created by the previously untested Outer Space Treaty (OST) perpetuated worry surrounding the existence of private property rights in space. With the passage of the recent SREU Act, many domestic worries were dismissed by the definitive granting of commercial property rights to U.S. citizens, yet equally many worries continue to surround the legitimacy of the SREU Act itself, as certain legal experts both inside and outside the U.S. argue the Act to be a violation of U.S. international obligations.
In contrast to the OST, the SREU Act explicitly grants Americans the right to hold and obtain material resources from celestial bodies such as asteroids and minor planets. This paper examines the implications of such a legal gray area by examining the extent to which select clauses of the OST may or may not conflict with such definitive legislation. Ultimately, it is concluded that the issue is far from settled, as the existence of celestial property rights may not presently be as clear as investors might hope.
ASSESSMENT OF THE ROLE OF CRP AND PLATELET COUNT IN EARLY NEONATAL SEPSIS
Authors: Shaha Sachin Walchand 
Published: October 2021

Material and Methods: A Prospective study was performed in the department of Pediatrics in territory care institute for the duration of 8 months. Forty newborns were included in the study group to satisfy including criteria. Before antibiotic treatment, neonates CRP and platelet count were assessed. Data were analyzed by SPSS software.
Results: Out of the 40 cases, 22 were male babies, and the rest 18 were female. Blood culture was positive in 19 out of the 40 cases, CRP was positive in 21 cases, and thrombocytopenia was observed in 16 cases. Klebsiella is the commonest gram organism causing sepsis in the Neonatal Intensive Care Unit. The Gram-positive organisms grown are Coagulase Positive and Coagulase-negative Staphylococci, Group B Beta Hemolytic Streptococcus, and Enterococcus. Out of 16 thrombocytopenia neonatal, 15 shows Gram-negative and 1 shows gram-positive blood culture.
Conclusion: Qualitative analysis of C-reactive protein can be used as an early marker of sepsis, especially in resource-limited settings. Although thrombocytopenia occurs predominantly in gram-negative sepsis, there is insufficient evidence to support the use of platelet count to differentiate between gram-positive and gram-negative sepsis.
Keywords: CRP, Platelet count,blood cultures, sepsis.
Sistem Monitoring Perawatan dan Perbaikan Fasilitas Gardu PT PLN Area Kota Metro
Authors: Wantoro Agus 
Published: October 2021

PT Perusahaan Listrik Negara (PLN) PERSERO Area Metro adalah sebuah Badan Usaha Milik Negara (BUMN) yang beralamat di jalan Alamsyah Ratu Prawiranegara No. 99 15A Kauman Metro, Lampung. Penanggulangan laporan gangguan gardu distribusi, petugas sering kali kesulitan dalam pencarian lokasi gardu di lapangan, berimbas pada waktu kerja petugas, belum adanya sistem yang dapat melakukan monitoring terhadap perbaikan dan perawatan fasilitas, belum ada jadwal perawatan yang terkoordinir antara rayon satu dengan rayon lainnya sering kali membuat petugas kewalahan, penggunaan peta konvensional yang sering membingungkan petugas baru dan lama, belum adanya sistem yang dapat menjembatani kantor rayon dengan gudang tekait permintaan barang. Salah satu solusi yaitu dengan dibuatnya sistem yang dapat memberikan informasi Pemetaan Perbaikan dan Perawatan Fasilitas PT. PLN Area Metro yang digunakan sebagai pengambilan informasi penyebaran distribusi maupun kerusakan area gardu listrik, menjembatani kantor rayon dan gudang dalam hal permintaan suku cadang, serta mengatur jadwal perawatan dan perbaikan gardu distribusi. Sistem yang dibangun telah diuji dengan ISO 25010 dengan nilai persentase yang diperoleh menunjukkan kualitas perangat lunak dengan karakteristik functionality dan usability mempunyai skala sangat layak, lalu karakteristik reliability dengan skala layak, dapat disimpulkan bahwa fungsionalitas sistem dapat berfungsi dengan baik dan dapat digunakan
Rancang Bangun Geographic Information System (GIS) Sebagai Pengembangan Sistem Monitoring Area Perkebunan Berbasis IoT
Authors: Thereza Nadia , Saputra Iwan Pahendra Anto , Husin Zaenal 
Published: October 2021

Operasional sektor perkebunan di Indonesia sebagian besar masih mengandalkan sistem konvensional yang menggunakan tenaga manusia untuk melakukan kontrol ke lapangan. Dengan kondisi tersebut, masih sulit jika ingin melakukan peningkatan kinerja operasional menjadi lebih efisien, efektif, dan produktif. Ditambah lagi, kondisi pandemi yang tengah dihadapi saat ini secara tidak langsung sangat berdampak dan berpotensi menurunkan angka produktivitas. Sistem operasional ataupun pengelolaan lahan perkebunan harus mengalami perubahan. Pemanfaatan teknologi dan inovasi sangat dibutuhkan untuk membantu mempertahankan ataupun meningkatkan kualitas dan kuantitas hasil produksi. Oleh sebab itu, dibutuhkan suatu rancangan sistem informasi berbasis website, yang bekerja menyampaikan informasi kondisi geografis suatu area secara real-time sebagai solusi dari permasalahan pemantauan kondisi geografis. Sistem informasi tersebut bekerja menggunakan informasi berupa data spasial (bereferensi geografis) yang dikenal dengan Sistem Informasi Geografis atau Geographic Information System (GIS).Tujuan penelitian ini adalah untuk membangun GIS berbasis web guna memberikan informasi dan menggambarkan kondisi (normal, rawan, kritis) pada suatu area/lahan secara real-time. Metode penelitian ini terdiri dari lima tahapan, yaitu persiapan penelitian (studi literatur), pengkajian objek (observasi, analisis kebutuhan sistem), perancangan dan pembangunan GIS dan integrasi dengan IoT, analisis dan pengujian penerapan GIS, serta penarikan kesimpulan. Sistem informasi geografis yang dibuat adalah dengan menampilkan peta (maps) area yang dipantau. Perangkat lunak yang digunakan untuk menampilkan maps adalah Google Maps Platform yang mana pada platform tersebut terdapat interface yang disebut API (Application Programming Interface). Google Maps API digunakan untuk menghubungkan sistem informasi geografis yang berbasis website dengan google maps. GIS memberikan informasi dan menggambarkan kondisi geografis suatu area secara real-time, kondisi area yang normal ditandai dengan warna hijau, kondisi antara (rawan kritis) ditandai dengan warna kuning serta kondisi area yang kritis ditandai dengan warna merah. Dengan adanya sistem informasi geografis, maka membantu para pekerja lapangan dalam memantau kondisi geografis suatu area secara real-time tanpa harus berada langsung di lokasi. Berdasarkan hasil penilaian pengguna, sebagian besar menyatakan “sangat setuju” bahwa GIS ini bermanfaat, bersifat user-friendly, mudah diakses kapanpun dan di manapun, serta memiliki kecepatan akses yang baik. Selain itu, sebagian besar juga menyatakan “setuju” bahwa GIS mampu menampilkan informasi yang akurat dan dapat membantu pekerjaan.
Sistem Pakar Deteksi Awal Covid-19 Menggunakan Metode Certainty Factor
Authors: Fahindra Aulia Rahman , Al Amin Imam Husni 
Published: October 2021

Virus corona 2019 (corona virus disease/COVID-19) merupakan virus baru yang muncul di Wuhan,China pada akhir tahun 2019, gejala umum yang ditimbulkan dari covid-19 adalah suhu tubuh naik, demam, mati rasa, batuk, nyeri di tenggorokan, kepala pusing, susah bernafas jika virus corona sudah sampai paru-paru. Untuk mengetahui seseorang terjangkit covid-19 pun cukup sulit karena memiliki gejala yang mirip dengan beberapa penyakit lainnya. Deteksi Covid-19 merupakan tahapan penting untuk mengenali secara dini pasien terduga Covid-19 sehingga dapat dilakukan langkah lanjutan. Salah satu cara pendeteksian adalah dengan sistem pendeteksi awal covid-19. Dengan keadaan tersebut tentunya dibutuhkan sistem pakar yang dapat melakukan sebuah deteksi awal terhadap gejala covid-19 . Namun demikian dibutuhkan sebuah metode untuk mengakomodasi faktor-faktor yang ada, sehingga di dapat hasil yang akurat. Metode Certainty Factor dipilih untuk mengakomodasi faktor ketidakpastian untuk diubah menjadi faktor kepastian, certainty factor juga dapat menyatakan kepercayaan dalam sebuah kejadian (fakta atau hipotesa) berdasar bukti atau laporan pakar dengan menggunakan suatu nilai untuk mengasumsikan derajat keyakinan seorang pakar terhadap suatu data.Hasil Penelitian dapat membantu masyarakat untuk melakukan diagnosa mandiri, dan paramedis untuk melakukan diagnosa awal kepada pasien, sehingga dapat mempermudah semua pihak dalam menangani Covid-19.
Sistem Informasi Monitoring dan Reporting Quality Control Proses Laminating Berbasis Web Framework Laravel
Authors: Herdiansah Arief , Borman Rohmat Indra , Maylinda Sonia 
Published: October 2021

PT Victory Chingluh Indonesia merupakan perusahaan yang bergerak dibidang industri manufacture yang memproduksi sepatu olahraga merk global, karena itu hasil proses produksi yang berjalan di setiap proses produksi harus merupakan hasil yang sesuai dengan standard kualitas yang sudah ditetapkan Perusahaan. Penelitian ini merupakan penelitian terapan yang dilakukan di bagian Quality Control (QC) PT Victory Chingluh Indonesia khususnya monitoring dan reporting proses laminating. Saat ini proses cek kualitas hasil produksi dan proses pembuatan laporan QC belum dilakukan menggunakan sebuah sistem informasi berbasis komputer, sehingga peneliti merasa perlu untuk membantu mengembangkan sistem informasi monitoring dan reporting quality control. Dalam proses pengumpulan data, peneliti melakukan metode survey dan wawancana kepada staf terkait dibagian QC proses laminating. Peneliti menggunakan UML (Unified Modeling Language) dalam proses perancangan sistem informasi dan peneliti menggunakan bahasa pemrograman PHP dengan framework laravel dalam tahap pengembangan sistem. berbasis database dan web. Pada tahapan akhir pengembangan, sistem yang dihasilkan diuji dengan menggunakan metode pengujian black box. Sistem yang dihasilkan telah dapat membantu staf QC me-monitoring hasil pekerjaan QC dan membuat laporan QC hasil proses produksi dengan cepat dan tepat, sistem yang dihasilkan juga menghasilkan sebuah laporan dalam bentuk dashboard (grafik) yang dapat mempermudah manajemen untuk melakukan analisa laporan hasil produksi QC di PT Victory Chingluh Indonesia
46, XY DSD (Disorder of Sex Development) : Diagnosis dan Tatalaksananya.
Authors: Felicia Mildi , Suhartono Beto 
Published: October 2021

Disorder of Sex Development (DSD) is a congenital disorder that occurs in the development of chromosomes, gonads, and internal or external genital organ. DSD of 46 XY is a condition where the children with XY genotype is not able to have complete virilization of external genital. Determination phase is an initial phase of reproductive system development. Disruption of this phase may potentially lead to DSD. Optimal care for children with Disorder of Sex Development requires a multidisciplinary team starting since neonatal period. Family and pregnancy history, complete physical examination and assessment of genital organ are the first step of ensuring the diagnose. Management of children with DSD are focusing on gender determination, hormone support therapy and surgical management. On the other hand, Children with XY genotype should be raised as a boy however if there is no responsive evidence in administration of androgen the children should be raised as a girl. Subsequent to prescribe the gender of the children, surgical management is a required treatment for removing unnecessary genital afterward.
Keywords: Disorders of Sex Development, DSD, 46 XY DSD
Gambaran Kepatuhan Mahasiswa Pre Klinik FK UKI dalam Menjalankan Protokol Kesehatan New Normal Pandemi Covid-19
Authors: Simanungkalit Bona 
Published: October 2021

Abstrak
Kepatuhan masyarakat menjalankan protokol kesehatan berpengaruh menekan penularan Covid-19. Perilaku physical distancing mahasiswa Universitas Islam Negeri (UIN) Syarif Hidayatullah Jakarta hanya 55,9%.1 Perilaku hand wash mahasiswa Universitas Muhammadiyah Magelang 52,6%.2 Untuk mengetahui kepatuhan mahasiswa dalam melakukan tes kesehatan mandiri, pemeriksaan suhu, penggunaan masker, faceshield, hand hygiene, menjaga jarak, waktu berada di kampus, konsumsi vitamin C, dan membersihkan diri setelah pulang. Desain penelitian adalah deskriptif. Pengambilan data menggunakan kuesioner, pengambilan sampel dengan teknik cluster random sampling, jumlah sampel 269 mahasiswa. Kepatuhan mahasiswa dalam menjalankan tes kesehatan mandiri 56,3%; pemeriksaan suhu 94%; penggunaan masker 98,9%; faceshield 46,1%; hand hygiene 80,7%; physical distancing 52,4%; berada di Fakultas Kedokteran Universitas Kristen Indonesia dalam waktu singkat 95,1%; konsumsi vitamin C 28,6%; membersihkan diri 73,6%. Sebanyak 93,5% mahasiswa tidak patuh dalam menjalankan protokol kesehatan.
Kata Kunci: Kepatuhan, Mahasiswa FK UKI, Protokol Kesehatan, Covid-19
RFWD3 Participates in the Occurrence and Development of Colorectal Cancer via E2F1 Transcriptional Regulation of BIRC5
Authors: Xu Fenghua , Xiao Zhifeng , Fan Liqin , Ruan Guangcong , Cheng Yi , Tian Yuting , Chen Minjia , Chen Dongfeng , Wei Yanling 
Published: October 2021

Objectives: Colorectal cancer (CRC) is one of the most common human malignancies. It was reported that the alterations in the DNA damage response (DDR) pathways are emerging as novel targets for treatment across different cancer types including CRC. RFWD3 plays a critical role in replication protein A (RPA)-mediated DNA damage in cancer cells. More importantly, RFWD3 can response to DNA damage by positively regulating p53 stability when the G1 cell cycle checkpoint is activated. However, the functional significance of RFWD3 in CRC has not been reported in the existing documents.Materials and Methods: Here, we revealed high expression of RFWD3 in CRC tissues by IHC analysis and The Cancer Genome Atlas (TCGA) database. Besides, overexpression of RFWD3 in CRC cell lines was also confirmed by qRT-PCR and western blot assay. The Celigo cell counting method and wound-healing/transwell migration assay were applied to evaluate CRC cell proliferation and migration. The tumor growth indicators were quantified in nude mice xenografted with shRFWD3 and shCtrl RKO cells.Results: The results indicated that RFWD3 knockdown restricted CRC development in vitro and in vivo. In exploring the downstream mechanism of RFWD3’s action, we found that RFWD3 could transcriptionally activate BIRC5 by interacting with E2F transcription factor 1 (E2F1). Accordingly, we identified BIRC5 as a downstream gene of RFWD3 regulating CRC. Subsequent loss- and gain- of function experiments demonstrated that upon overexpressing BIRC5 in RKO cells with down-regulated RFWD3, the inhibitory effects of cell proliferation, migration and colony formation could be reversed, while the capacity of cell apoptosis was ameliorated, suggesting that the effects of RFWD3 depletion was mainly due to BIRC5 suppression.Conclusion: Taken together, this study revealed that RFWD3 participates in the occurrence and development of colorectal cancer via E2F1 transcriptional regulation of BIRC5.