bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric properties of a novel burnout assessment instrument: Individualized Burnout and Contributors Scale (IBOCS)
Authors: Hudziak Jim , Morrell Zoe , Schork Nicholas J. , Graf Arnulf , Lincoln Lucy , Smalley Sue , Freckleton Dustin , Copeland William E , Rettew David 
Published: November 2021

Abstract
Background: Self-report of burnout is important in understanding how individuals are coping with the stress in their lives. Traditionally, burnout has been measured as a factor of work-related stress. However, with increasing reports of burnout related to areas of life outside of work among teens and young adults, the need has developed for a more comprehensive burnout measure targeted to a younger population. This study introduces the Individualized Burnout and Contributors Scale (IBOCS), an instrument designed to be administered on digital devices, and comprised of two separate measures that evaluate overall burnout level and burnout contributors. The IBOCS is unique in that it aims to assess comprehensive burnout, focusing not only on occupational factors, but on other potential life stressors as well. Additionally, the IBOCS can be administered easily on digital platforms, which is especially important in engaging younger populations. Unlike many other existing burnout scales that are costly to administer and are scored manually, the IBOCS is intended to be used as a free, easily accessible tool that is aimed at empowering individuals to measure and monitor their burnout frequently. Methods: A sample of 1,244 individuals completed an online survey battery that assessed contributors to burnout along with measures of wellbeing, perceived self-stress, and stress personality.Results: Exploratory and Confirmatory Factor Analyses, Recursive Feature Elimination and regression analysis of the IBOCS burnout level items yielded a two-factor model with dimensions labeled: 1) Exhaustion; and 2) Fulfillment. Similar analyses of the IBOCS burnout contributor scale yielded a two-factor model with dimensions labeled: 1) Negative; and 2) Positive. Our analyses reveal evidence of multiple contributors to burnout including struggles with personal relationships, health concerns, time spent in the digital space, financial worries, and work or school-related stresses. Subsequent correlation analyses suggested strong convergent validity between the IBOCS and established rating scales of perceived self-stress, stress personality, happiness, and overall wellbeing.Conclusion: We conclude that the IBOCS has solid psychometric foundations and reflects important characteristics of burnout and burnout contributors. The implications of this work are discussed in the context of positive psychology to help individuals interrupt the progression of burnout in their lives.
Treatment of MDA5-positive dermatomyositis complicated by gangrenous cholecystitis with tofacitinib
Authors: Luo Man , Chen Long , He Huan , He Fang 
Published: November 2021

Abstract
BackgroudDermatomyositis is a diffuse skeletal myositis disease with a variety of causes.The onset is mainly related to humoral immune abnormalities.Some therapeutic drugs,such as hormones and immunosu -ppressants,have poor therapeutic effects.In recent years, tofacitinib has been reported to be effective in the treatment of dermatomyositis.But there are many reports about the treatment of autoimmune diseases and infectious diseases with tofacitinib.Case presentationWe report a case of MDA5 antibody-positive dermatomyositis that was relieved after treatment with tofacitinib,during which gallbladder gangrene and suppurative cholecystitis occurred.After cholecystectomy,we continued to use tofacitinib and achieved good therapeutic effect. ConclusionsTofacitinib is effective in the treatment of MDA5 antibody-positive dermatomyositis,but the risk of infection is increased.It can still be used after infection control.A close follow-up should be performed during the use of tofacitinib.
Altered Cytokine and BDNF Levels in Individuals with Autism Spectrum Disorders
Authors: Han Yvonne M.Y. , Yau Suk Yu , Chan Melody M.Y. , Wong Chun Kwok , Chan Agnes S. 
Published: November 2021

Abstract
Previous studies have shown that immunological factors are involved in the pathogenesis of autism spectrum disorders (ASDs). The present study examined whether immunological abnormalities are associated with cognitive deficits and problem behaviors in children with ASD and whether children with ASD show different immunological biomarkers and brain-derived neurotrophic factor BDNF levels than typically developing (TD) children. Sixteen TD and 18 children with ASD, aged 6–18 years, voluntarily participated in the study. Participants’ executive functions were measured using neuropsychological tests, and behavioral measures were measured using parent ratings. Immunological measures were assessed by measuring the levels of chemokine ligand 2 (CCL2) and chemokine ligand 5 (CCL5) in participants’ blood serum. Children with ASD showed greater deficits in cognitive functions as well as altered levels of immunological measures when compared to TD children, and their cognitive functions and behavior deficits were significantly associated with increased CCL5 levels and decreased BDNF levels. These results provide evidence to support the notion that altered immune functions are associated with neuronal deficits, are indexed by decreased levels of BDNF and manifest as selective cognitive and behavioral symptoms in individuals with ASD.
Antimonene-gold Based Twin-Core SPR Sensor with Side Polished Semi-Arc Groove Dual Sensing Channel: An Investigation with 2D Material
Authors: Singh Shivam , Prajapati Yogendra Kumar 
Published: November 2021

Abstract
We propose surface plasmon resonance (SPR) based single-side polished photonic crystal fiber (SSP-PCF) sensor for low as well as high refractive index (RI) sensing. To achieve this, an active metal gold (Au) is deposited on the PCF's flat narrow channels to form a dual-sensing channel. Following that, a thin nanolayer antimonene is deposited on Au, as its buckled honeycomb lattice structure aids in the trapping of numerous biomolecules. For the sensing range of 1.27 to 1.39, numerical results show that the wavelength sensitivity (WS) and amplitude sensitivity (AS) mounted on 77000 nmRIU-1 and 1320.41 RIU-1, respectively, with wavelength resolution (RW), and amplitude resolution (RA), as high as 1.298\(\times\)10-6 RIU, and 8.6\(\times\)10-7 RIU. The promising results obtained from the proposed SSP-PCF sensor offers improved refractive index sensing with a fine figure of merit (FOM), i.e., 311.74 RIU-1 for the sensing range of 1.27 to 1.39, which covers most known analytes such as proteins, cancer cells, glucose, viruses, DNA/RNA, medicinal drugs, halogenated organic acids. Further, the proposed sensor's design requires a simple fabrication procedure.
Clinical Characteristics, Treatment Outcomes, And Genetic Alterations of Radiation-Induced Gliomas
Authors: Ohno Makoto , Miyakita Yasuji , Takahashi Masamichi , Yanagisawa Shunsuke , Tamura Yukie , Kawauchi Daisuke , Kikuchi Miyu , Igaki Hiroshi , Yoshida Akihiko , Satomi Kaishi , Matsushita Yuko , Ichimura Koichi , Narita Yoshitaka 
Published: November 2021

Abstract
Purpose: We aimed to elucidate the clinical characteristics, treatment outcomes, and genetic alterations in patients with radiation-induced glioma (RIG).Methods: Patients with high-grade glioma who satisfied the Cahan’s criteria for RIG in our database during 2001–2021 were included. Isocitrate dehydrogenase (IDH) 1 and 2, telomerase reverse transcriptase (TERT) promoter, B-Raf (BRAF), and histone H3.3 (H3F3A) and methylation status of the O-6-methylguanine DNA methyltransferase (MGMT) promoter were analyzed. Methods: We identified 11 patients with RIG, including 7 glioblastoma (GBM), IDH1/2-wildtype; 2 GBM, not otherwise specified (NOS); 1 anaplastic astrocytoma (AA), IDH1/2-wildtype; and 1 AA, NOS. The median latency period was 17 years (range: 9–30 years). The median progression-free survival (PFS) and median survival time (MST) were 11.3 months and 28.3 months, respectively. The median PFS in patients treated with initial reirradiation (N = 5) tended to be longer than that in patients without initial reirradiation (N = 6) (17.0 vs 8.1 months; p = 0.51), but not MST (29.6 vs 27.4 months; p = 0.28). There were no alterations in IDH1/2, TERT promoter, BRAF and H3F3A mutations. Two tumors had a hypermethylated MGMT promoter. In one case, different IDH2 mutation status between primary and secondary tumor was useful to diagnose the secondary tumor as RIG. Conclusions: RIG may occur more than 20 years after the treatment for primary disease; therefore, long-term follow-up is needed. Reirradiation could be a therapeutic option for RIG. Identifying IDH1/2 mutation status has a diagnostic impact on establishing RIG in cases of recurrent glioma.
Influence of Strong Light on the Performance of Piezoresistive Pressure Sensor
Authors: Huang Mimi , Zhao Libo , Wu Zutang , Han Xiangguang , Yu Mingzhi , Chen Yao , Yang Ping , Wang Xiaozhang , Wang Yonglu , Wang Jiuhong , Jiang Zhuangde 
Published: November 2021

Abstract
It is found that the strong light in the explosion field has great interference to the piezoresistive pressure sensor, then the shock wave data obtained by the sensor is distorted badly. To study the influence mechanism of the strong light on the piezoresistive pressure sensor, a strong light experimental platform is built. The positions of the sensor and the light source are adjusted, and the outputs of the piezoresistive pressure sensor are observed. Through microscopic simulation, the influence of different light intensities on the piezoresistive pressure sensor is analyzed. In order to reduce the influence of strong light on the performance of piezoresistive pressure sensor, we propose to add a reflective layer on the pressure surface of the sensor. The light reflection effects of different film thicknesses are analyzed through film simulation software. At the same time, the reflection effect is verified through experiments. To explain the effect of the reflective layer on the suppression of strong light, a simulation model is established, and the suppression effect of the reflective layer is verified.
Chronic nonbacterial osteomyelitis in children: a multicentre Belgian cohort of 30 children
Authors: Kaut Sara , Wyngaert Ine Van den , Christiaens Davy , Wouters Carine , Noppe Nathalie , Herregods Nele , Dehoorne Joke , De Somer Lien 
Published: November 2021

Abstract
BackgroundTo evaluate clinical characteristics, imaging findings, therapeutic approach and outcome of paediatric patients with Chronic Non-Bacterial Osteomyelitis (CNO). MethodsRetrospective review of 30 children diagnosed with CNO at two tertiary care centres in Belgium. Imaging data were evaluated by blinded paediatric radiologists. ResultsMean age at onset was 10.3 years and mean age at diagnosis was 11.7 years. Bone pain was the leading symptom (29/30 patients). Out of 180 symptomatic lesions, 131 were confirmed on MRI as hyperintense geographic lesions on STIR images at the metaphysis and epiphysis adjacent to growth plates of tubular bones. The most common sites of involvement were the lower limbs, spine, sternoclavicular joint and humerus. For nearly half of the patients (14/30) monotherapy with NSAIDs was sufficient to obtain remission. The remaining 16 patients received second-line therapy: bisphosphonates (n=15/30), disease-modifying antirheumatic drugs (n=7/30), etanercept (n=4/30) and tocilizumab (n=1/30). 26/30 Patients reached remission after a mean time of 37.6 months. The prognosis was worse for patients with spinal involvement, resulting in more long-term sequelae. ConclusionsWe present a multicentre paediatric cohort of 30 CNO patients. A typical pattern of bone involvement could be found on MRI. NSAIDs were administered as first-line treatment. Second-line strategies included bisphosphonates, corticosteroids, methotrexate, etanercept and tocilizumab. Trial registrationRetrospectively registered.
Effect of Fibrin Sealant on Knee Function Restoration Following Total Knee Replacement: A Meta-analysis
Authors: Lu Kongye , Lu Mengqi , Pei Yunlong , Shi Pengzhi , Zhang Jin , Hou Tuanjie , Chen Xiao 
Published: November 2021

Abstract
Objective: The aim of present study was to evaluate the efficacy and safety of fibrin sealant on knee function restoration following total knee replacement. Methods: PubMed, Web of Science, Cohrane library, and Embase were searched up to August 2021. All prospective randomized controlled trial involving fibrin sealant treatment for total knee replacement were included in this meta-analysis. Range of motion, total blood loss, blood transfusion rate, hemoglobulin reduction, hospital stay, and complication were calculated using RevMan 5.4 software.Results: Totally 23 randomized clinical trials involving 2267 patients (1136 patients for fibrin sealant group and 1131 patients for control group) were finally included. The results indicated that that the usage of fibrin sealant in total knee replacement can reduce the total blood loss [95% (-935.81, -351.70), P<0.0001], transfusion rate [95%CI (0.47, 0.90), P=0.01], hemoglobulin reduction [95%CI (-2.94, -0.74), P=0.001] and hospital stay [95%CI (-1.76, -0.42), P=0.001] without increasing the rate of complication [95%CI (-0.04, 0.02), P=0.42], but cannot increase the knee range of motion [95%CI (-1.17,9.29), P=0.13].Conclusion: The usage of fibrin sealant can effectively reduce the total blood loss, transfusion rate, hemoglobulin reduction and hospital stay without increasing the rate of complication, but cannot increase the knee range of motion
Mechanical Effects of Canes on Postural Control: Beyond Perceptual Information
Authors: Russo Marta , Lee Jongwoo , Hogan Neville , Sternad Dagmar 
Published: November 2021

Abstract
BackgroundNumerous studies showed that postural balance improves through light touch on a stable surface highlighting the importance of haptic information, seemingly downplaying the mechanical contributions of the support. The present study examined the mechanical effects of canes for assisting balance in healthy individuals challenged by standing on a beam. MethodsSixteen participants supported themselves with two canes, one in each hand, and applied minimal, preferred, or maximum force onto the canes. They positioned the canes in the frontal plane or in a tripod configuration. ResultsResults showed that canes significantly reduced the variability of the center of pressure and center of mass to the same level as when standing on the ground. In the preferred condition, participants exploited the altered mechanics by resting their arms on the canes and, in the tripod configuration, allowing for larger CoP motions in the task-irrelevant dimension. Increasing the exerted force beyond the preferred level yielded no further benefits, in fact had a destabilizing effect on the canes: the displacement of the hand on the cane handle increased with the force. ConclusionsDespite the challenge of a statically unstable system, these results show that, in addition to augmenting perceptual information, using canes can provide mechanical benefits and challenges. First, the controller minimizes effort channeling noise in the task-irrelevant dimensions and, second, resting the arms on the canes but avoiding large forces that would have destabilizing effects. However, if maximal force is applied to the canes, the instability of the support needs to be counteracted, possibly by arm and shoulder stiffness.
Arginine Methyltransferase PRMT5 Methylates and Destabilizes Mxi1 to Confer Radioresistance in Lung Cancer
Authors: Yang Xijie , Zeng Zhen , Jie Xiaohua , Wang Ye , Han Jun , Zheng Zhikun , Li Jinsong , Liu Hongli , Dong Xiaorong , Wu Gang , Xu Shuangbing 
Published: November 2021

Abstract
BackgroundRadioresistance is regarded as the main cause of local recurrence and distant metastasis in lung cancer. However, the underlying mechanisms of radioresistance remain incompletely understood. This study investigates the roles and regulatory mechanisms of arginine methyltransferase PRMT5 in lung cancer radioresistance.MethodsImmunoprecipitation assay and GST pulldown were used to detect the protein-protein interaction. The methylation of Mxi1 was determined by in vivo and in vitro arginine methylation assays. In vivo ubiquitination and CHX chase assays were performed to examine the stability of Mxi1. The biological effects of PRMT5 and its specific inhibitor EPZ015666 in lung cancer were evaluated both in vitro and in vivo.ResultsWe show that the arginine methyltransferase PRMT5 interacts with and methylates Mxi1, which promotes the binding of the β-Trcp ligase to Mxi1, facilitating the ubiquitination and degradation of Mxi1 in lung cancer. Furthermore, genetic blockade of PRMT5 impairs DNA damage repair and enhances lung cancer radiosensitivity in vitro and in vivo, and these phenotypes are partially reversed by Mxi1 silencing. More importantly, pharmacological inhibition of PRMT5 with the specific inhibitor EPZ015666 leads to extraordinary radiosensitization in vitro and in vivo in lung cancer.ConclusionsOur data indicate that PRMT5 methylates and destabilizes Mxi1 to confer radioresistance, suggesting that PRMT5 may be a promising radiosensitization target in lung cancer.
Using X-Ray As An Irradiation Source For Direct ESR Dating of Fossil Teeth
Authors: Yu Wenjing , Herries A.I.R. , Joannes-Boyau R. 
Published: November 2021

Abstract
In this paper we have tested the potential application of X-rays as an irradiation source in Electron Spin Resonance dating of tooth enamel. Both modern and fossil samples were used to assess the feasibility of dose estimations using this alternative irradiator. Equivalent doses obtained with gamma-rays on fossil powder enamel was frequently less than the doses obtained on fragments using only X-rays. It is believed that a combination of NOCORs (non-orientated CO2- radicals) and local internal dose discrepancy may be the origin of the difference. Here, we show that testing penetration attenuation for each individual irradiation source is required to accurately estimate the maximum enamel thickness and produce reliable protocols. The use of a known laboratory additive dose allows the calculation of an absorption equivalent coefficient between gamma-rays and X-rays. We conclude that X-rays are an alternative irradiation source for ESR dating protocols, however, limitations remain in particular with alpha efficiency.
Case Report: Acute Submandibular Glanditis Caused by Nasogastric Tube Feeding in A Subject with Poorly Controlled Diabetes Mellitus
Authors: Iwamoto Yuichiro , Anno Takatoshi , Koyama Katsumasa , Tomoda Koichi , Kimura Tomohiko , Kaneto Hideaki 
Published: November 2021

Abstract
Background

Enteral tube feeding is an effective method of providing nutrients for patients who are unable to meet their nutritional requirements and patients with parenteral nutrition are possible the increased risk of infection. The submandibular gland is one of the salivary glands and some of sialadenitis are caused by obstruction of the salivary outflow tract.

Case presentation

A 91-year-old woman had parenteral nutrition with nasogastric tube feeding. Her background history was repeated angina and myocardial infarction and performed percutaneous coronary intervention and coronary artery bypass grafting, type 2 diabetes (T2DM), heart failure, atrial fibrillation and sick sinus syndrome and performed, pacemaker placement. She was continued parenteral nutrition with nasogastric tube feeding for 20 days, and suddenly she had high fever and elevated infection markers under poorly glycemic control. We diagnosed her as acute submandibular glanditis. We treated her with antibiotics therapy, extubation, daily massage of the submandibular gland and strict glycemic control, and her neck swelling disappeared about 11 days after such treatment.

Conclusions

We reported acute submandibular glanditis induced by nasogastric tube feeding under poorly controlled diabetes mellitus. We have to pay attention to glycemic control in subjects under parenteral nutrition with tube feeding management.
May hepatic steatosis be associated with gynecomastia and epicardial fat? A retrospective study of 599 male patients
Authors: Aksoy Suleyman Hilmi , Aydin Selami , Yurdaisik Isil , Dalkilic Orhan 
Published: November 2021

Abstract
Objective

There is no study in the literature investigating the association of hepatic steatosis with both gynecomastia and epicardial fat thickness together. We aimed to determine the correlations between hepatic steatosis through liver density, gynecomastia and epicardial fat thickness in patients undergoing CT scans due to suspected COVID-19 symptoms.
Methods

A total of 599 male patients who underwent chest CT scans due to a presumed diagnosis of COVID-19 in our radiology clinic were included in the study. Patients’ age, diameters of the subareolar glandular tissues of the right and left breasts, the right retroareolar fatty tissue, liver and spleen density, epicardial fat thickness and biochemical parameters were recorded and analyzed. The laboratory analyses were performed according to the standard methods.
Results

The mean age of the patients was 47.21±15.00 years. The left subareolar tissue thickness and the right retroareolar fatty tissue thickness that are used to indicate the presence of gynecomastia were found to be significantly correlated with liver density in negative direction (r=-.137, p<0.001; r=-.172, p<0.001; respectively). Epicardial fat thickness was statistically significantly correlated with right subareolar tissue thickness (r=.085, p=0.037), left subareolar tissue thickness (r=.101, p=0.014) and right retroareolar fatty tissue thickness (r=.148, p<0.001).
Conclusion

The results of this study showed that gynecomastia was significantly correlated with both age and hepatic steatosis. Epicardial fat thickness was also associated with liver steatosis. We demonstrated the significant correlations between epicardial fat thickness and gynecomastia for the first time. Nevertheless, our results need to be confirmed by further comprehensive studies.