bluuebunny/crossref_metadata_2025_split huggingface dataset:
The confidante method to measure abortion: implementing a standardized comparative analysis approach across seven contexts.
Authors: Owolabi Onikepe Oluwadamilola , Giorgio Margaret , Leong Ellie , Sully Elizabeth 
Published: October 2021

Abstract
Background
Obtaining representative abortion incidence estimates is challenging in restrictive contexts. While the confidante method has been increasingly used to collect this data in such settings, there are several biases commonly associated with this method. Further, there are significant variations in how researchers have implemented the method and assessed/adjusted for potential biases, limiting the comparability and interpretation of existing estimates. This study presents a standardized approach to analyzing confidante method data, generates comparable abortion incidence estimates from previously published studies and recommends standards for reporting bias assessments and adjustments for future confidante method studies.
Methods
We used data from previous applications of the confidante method in Côte d’Ivoire, Ethiopia, Ghana, Java (Indonesia), Nigeria, Uganda, and Rajasthan (India). We estimated one-year induced abortion incidence rates for confidantes in each context, attempting to adjust for selection, reporting and transmission bias in a standardized manner.
Findings:
In each setting, majority of the foundational confidante method assumptions were violated. Adjusting for transmission bias using self-reported abortions consistently yielded the highest incidence estimates compared with other published approaches. Differences in analytic decisions and bias assessments resulted in the incidence estimates from our standardized analysis varying widely from originally published rates.
Interpretation:
We recommend that future studies clearly state which biases were assessed, if associated assumptions were violated, and how violations were adjusted for. This will improve the utility of confidante method estimates for national-level decision making and as inputs for global or regional model-based estimates of abortion.
Emergency Information Sharing Mechanism and Efficiency Measurement in Coastal Cities, China
Authors: Huang Xing , Huang Jieru 
Published: October 2021

Abstract
To establish and improve the theoretical framework and operation mechanism of emergency information sharing, and to establish the index system and evaluation method of the efficiency of emergency information sharing are the key work to improve the disaster prevention and mitigation capacity of coastal cities in China. In this paper, the synergetic theory is introduced into the construction of emergency information sharing framework. By clarifying the operation relationship between the participants and the information transmission, the framework and operation mechanism of emergency information sharing are constructed. Around the 3 dimensions of emergency information sharing mechanism construction, resource guarantee ability and collaborative driving force of emergency information sharing, the evaluation index system of emergency information sharing collaborative efficiency in coastal cities is proposed, and the evaluation method of emergency information sharing collaborative efficiency based on coupling degree model is proposed. The empirical results show that the efficiency of emergency information sharing in coastal cities in China is generally on the rise, and the contribution rate of the construction level of emergency information sharing mechanism is higher than that of the resource guarantee ability and the collaborative driving force of emergency information sharing, but the efficiency of emergency information sharing in coastal cities in China is still at the bottom level. The research results provide theoretical basis and methods for the emergency management departments of coastal cities in China.
Beta-Adrenergic Receptor Blockers and Hepatocellular Carcinoma Survival. A Systemic Review and Meta-Analysis
Authors: Chang Hyun , Lee Sung Hyun 
Published: October 2021

Abstract
IntroductionPre-clinical data has revealed that beta-adrenergic stimulation can affect the growth and progression of different types of malignancies. Beta-adrenergic receptor blockers have been associated with improved survival in patients with many types of cancer. We performed a meta-analysis to investigate the association between beta-blocker use and hepatocellular carcinoma (HCC) prognosis.MethodsIn this meta-analysis, a full search was conducted using PubMed, the Cochrane library, and Embase to identify all relevant studies published up to May 2021. Available hazard ratios (HRs) were extracted for overall survival (OS), cancer-specific survival (CSS) and pooled using a random effects meta-analysis.ResultsFour studies involving 7252 patients with HCC met the inclusion criteria and were included in the systemic review. Three studies that reported OS data of 5148 patients were included in the meta-analysis. The random-effects model showed that beta-blocker use was associated with significantly improved OS in HCC (HR = 0.69, 95% CI = 0.54-0.88, P = 0.0031), without significant heterogeneity (I2 = 41%; Q = 6.42, P = 0.18)ConclusionThis meta-analysis suggested that beta-blocker use can be associated with prolonged OS of patients with HCC.
Dietary Supplementation Of Rice Bran Crude Lecithin Affect Feed Digestion, Blood And Rumen Profile In Crossbred Calves
Authors: Tewari Dharmesh , Chaturvedi V.B. , Chaudhary Lal Chandra , Verma Ashok Kumar , Chaudhary Sandeep Kumar 
Published: October 2021

Abstract
The present study was conducted to evaluate the effect of rice bran crude lecithin (RBCL) on nutrient digestion and balance, performance, methanogenesis, blood and rumen profile. Eighteen crossbred calves were randomly divided into three groups; RBCL-0, RBCL-8 and RBCL-12 and fed wheat straw based diet with concentrate mixture containing 0, 8 and 12 % RBCL respectively. The dry matter, organic matter and crude protein intake were comparable but tended to decrease with the RBCL levels. The digestibility of dry matter, organic matter, total carbohydrate and gross energy tended to decrease while crude protein and ether extract digestibility tended to increase were with RBCL levels. The fibre fractions (NDF and ADF) digestibility was significantly (P < 0.01) lower in RBCL supplemented groups in comparison to control group. The body weight gain and average daily gain tended to decrease with increasing the level of rice bran crude lecithin. The percent of nitrogen and calcium retention tended to decrease, while phosphorus retention was significantly (P < 0.01) lower with inclusion level of RBCL. The methane production (L/d, L/kgW0.75) were significantly (P < 0.05) lower in RBCL-12 followed by RBCL-8 as compared to RBCL-0 group. Serum biochemical did not show significant difference among dietary treatment groups. The cholesterol and blood urea concentration was significantly (P < 0.01) higher in RBCL-12 group as compared to control group. The rumen metabolites and microbiota showed reduction in RBCL-8 group as compare to RBCL-0 group without reach to significant (P < 0.05) level. It can be concluded, that detrimental effect of present levels (8 and 12%) of RBCL was seen in the performance of crossbred calves, which was associated with decreased fibre digestibility and fermentation in rumen. Beside this, RBCL is helpful in methane mitigation for cleaner production and can be a cheap source of energy in place of corn for ruminant. Further studies in large number of livestock are warranted to explore the potential of RBCL in the ruminant ration.
Identification of ITPR1 as a hub gene of Group 3 Medulloblastoma and coregulated genes with potential prognostic values
Authors: Chagas Pablo Ferreira das , de Sousa Graziella Ribeiro , Veronez Luciana Chain , Martins-da-Silva Andrea , Corrêa Carolina Alves Pereira , Cruzeiro Gustavo Alencastro Veiga , Nagano Luis Fernando Peinado , Queiroz Rosane Gomes de Paula , Marie Suely Kazue Nagahashi , Brandalise Silvia Regina , Scrideli Carlos Alberto , Tone Luiz Gonzaga , Valera Elvis Terci 
Published: October 2021

Abstract
The Group 3 Medulloblastoma ( Grp3-MB ) is an aggressive molecular subtype with a high incidence of metastasis and deaths. In this study, were used an RNA sequencing data ( RNA-Seq ) from a Brazinian cohort of MBs to identify hub genes associated with the metastatic risk. Data validation were performed by using multiple large datasets from MBs (GSE85217, GSE37418, EGAS00001001953). DESeq2 package in R software was used to identify the differentially expressed genes ( DEGs ) in our RNA-Seq data. The DEGs data were accessed to construct the modules/graphs of coexpression and to identify hub genes through Cytoscape platform. The co-regulated genes were enriched by the Kyoto Encyclopedia of Genes and Genomes ( KEGG ) pathway and the Protein-protein interaction ( PPI ) network was visualized by Cytoscape. The Kaplan–Meier plotter and ROC curves were used to validate the diagnostic and prognostic values of specific biomarkers identified through this model. We identified that Inositol 1,4,5-triphosphate receptor type 1 ( ITPR1 ) as a downregulated hub gene, with a high diagnostic accuracy to Grp3-MBs and associated with tumor metastasis. In addition, we identified genes significantly correlated with ITPR1 that were associated with metastasis in Grp3-MB ( ATP1A2 , MTTL7A and RGL1) , and worst overall survival in MBs ( ANTXR1 and RGL1 ). Our findings suggest that the ITPR1 hub gene is potentially involved in the metastatic process for Grp3-MB. Our data also provide evidence of targets that may serve as prognostic predictors and/or regulators for the metastatic process that maybe explored for further research of individualized therapy to Grp3-MBs.
Air Pollution, Residents’ Happiness, and Environmental Regulation: Evidence from China
Authors: Xu Fang , Luo Xiao-Ling , Zhou Di 
Published: October 2021

Abstract
Using data from the China General Social Survey and data on air pollution, this study explores the impact and the critical path of air pollution on residents’ happiness in China and evaluates whether environmental regulations can alleviate these effects. A probit model is used to analyze the impact of air pollution on residents’ happiness, and wind speed is taken as the instrumental variable of air pollution to overcome endogeneity. A stepwise regression is used to test the critical path of air pollution on residents’ happiness. Finally, the effects of environmental regulations are considered by adding an interaction term between environmental regulation and air pollution. The following conclusions are drawn. First, air pollution can significantly impair residents’ happiness, especially those who have children, are younger, are in poor health, have a lower education level, have lower income, and live in a rural area. Second, there are two critical paths through which air pollution impairs residents’ happiness: mental health level and the frequency of leisure activities. Finally, command-and-control, market-based, and voluntary environmental regulations can all effectively alleviate the impact of air pollution on residents’ happiness.
E-learning Modules to Improve Clinical Reasoning and Practice: a Prospective Comparative Study
Authors: Stollar Fabiola , Cerutti Bernard , Aujesky Susanne , Scherly Daniel , Nendaz Mathieu , Galetto-Lacour Annick 
Published: October 2021

Abstract

Background: Controversy remains about how successfully e-learning can improve clinical skills and knowledge acquisition. Our study's main objective was to compare the effects of e-learning versus traditional education on medical students' reasoning and how they applied their knowledge to clinical skills by evaluating their performance in a pediatrics exam based on key features. Our secondary objectives were to assess the factors associated with e-learning that might influence exam scores and to evaluate medical students' satisfaction with these two learning methods. Methods: Prospective observational study of two pediatric clerkship cohorts (2016–17 and 2017–18) of fourth-year medical students at the University of Geneva's Faculty of Medicine, Switzerland. All students participated in a standardized program of traditional seminars and e-learning using case-based scenarios. To compare the two learning methods, we taught two subjects using traditional seminars in 2016–17 and then using e-learning modules in 2017–18. To evaluate factors that might have influenced e-learning's effects, we monitored the use of all the e-learning modules studied in the months preceding the pediatric exam. Student satisfaction was evaluated using a questionnaire of four-point Likert scale-like items. Results: We included 299 medical students. Students using interactive e-learning modules had the same median scores for exam questions associated with e-learning as students who attended traditional seminars (median 80%, IQR 67%–100% vs. median 80%, IQR 67%–100%; p=0.975). A linear regression model showed an association between the scores for exam questions associated with e-learning and the number of quizzes taken and sex. Even though the overall satisfaction with the two learning methods was similar, students claimed that they learned more in e-learning than in traditional seminars, that learning objectives were better explained in e-learning modules, and that traditional seminars were better integrated into the curriculum.Conclusions: We found no evidence of a difference in students’ reasoning and how they applied their knowledge to clinical skills between e-learning and traditional seminar-based methods. The number of quizzes taken and being a female student were factors associated with better scores. Overall, students were satisfied with both learning methods, but they claimed that they learned more with e-learning.
Damage Estimation using Shock Zones: A case study of Amphan tropical cyclone
Authors: Medha  , Mondal Biswajit , Doloi Gour , Islam S.M. Tafsirul , Bera Murari Mohan 
Published: October 2021

Abstract
The tropical cyclone affects millions of people living in the coastal regions. The changing climate has led to an increased intensity and frequency of cyclones, therefore increasing the damage caused to people, the environment, and property. The Bay of Bengal is most prone to tropical cyclones, which affects Bangladesh and the eastern coastal region of India due to geographical proximity. Hence, a comprehensive understanding of the inundation damage and intensity caused becomes essential to focus the relief efforts on the affected districts. This study identified the shock zone and assessed the inundation associated damage caused by recent cyclone Amphan in the area of Bangladesh and West Bengal in India. The shock zonation was based on the track of cyclones, cyclone wind speed zones, elevation, wind impact potentiality, and agricultural population area. The identification of the affected area was done using integrated Landsat and SAR data, and economic damage cost was assessed using the Asian Development Bank’s (ADB) Unit price approach. The total people affected due to inundation are 2.4 million in India and 1.4 million in Bangladesh and the damage totaled up to 5.4 million USD. The results of this study can be used by concerned authorities to identify the shock zones and be used for rapid assessment of the damages.
The community residents’ NIMBY attitude on the construction of community ageing care service centres: a cross-sectional study
Authors: Yu Bo , Han Yue-Hong , Sun Yin , Zhang Xu-Dong 
Published: October 2021

Abstract
Background: China is the country with the largest elderly population. To actively respond to this ageing population, China has proposed the Community Aged Care Service Centre (CACSC) network as the major elderly care development policy. However, many residents resisted the development of the CACSC network, which affected its smooth implementation. Based on the theory of “Not in My Backyard” (NIMBY), this paper proposes a model of the influencing factors of community residents on the opposition to the construction of CACSCs. Methods: In this study, residents of urban communities over the age of 20 in mainland China were the research target. After a total of 509 questionnaires were collected through online surveys, using IBM SPSS Statistics 25.0 and IBM SPSS Amos 24.0 to analyse the data. Results: The research results show that superstition, the NIMBY attitude, and perceived risk have a significant positive impact on the opposition to the construction of CACSCs, while the negative impact of perceived benefit on the opposition intention is not significant. Moreover, perceived knowledge has a significant positive impact on perceived benefit and a significant negative impact on superstition and perceived risk. Conclusions: Strengthen policy advocacy on ageing, clarify the service content of CACSC and encourage young people to participate in public welfare activities for the elderly can reduce the opposition of community residents to the construction of a CACSC.
Qiangli Wuhu Mixture Alleviates LPS-Induced Pneumonia by Inhibiting the TLR4/NF-κB/NLRP3 Pathway: A Study Based on Network Pharmacology
Authors: Tian Jie , Wang Xiao-Long , Wang Long-Cheng , Chen Fei , Tian Yun , Ma Li , Pan Chao-Yun , Wang Yan-Pinig 
Published: October 2021

Abstract
Background: This study aimed to clarify the mechanism of action of Qiangli Wuhu Mixture used in the treatment of pneumonia.Methods: The potential targets of Qiangli Wuhu Mixture in the treatment of pneumonia were predicted by network pharmacology. ICR male mice were randomly divided into 5 groups: normal control (Control), pneumonia model (Vehicle), low and high dose groups of Qiangli Wuhu Mixture, and dexamethasone positive control group with 12 mice in each. The model was established by tracheal instillation of lipopolysaccharide for 3 consecutive days. After the establishment of the animal model, Qiangli Wuhu Mixture was intragastrically administered for 5 days; the expression of inflammatory factors tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and anti-inflammatory factor interleukin-10 (IL-10) in the serum of mice in each group was detected by ELISA kit; the protective effect of Qiangli Wuhu Mixture on the lung tissue of pneumonia mice was observed by staining; Western Blot was used to detect the expression of Toll-like receptor 4 (TLR4), nuclear factor kappa B (NF-κB) and NLRP3 signal pathway related proteins in lung tissue.Results: Network pharmacology predicted that the target of Qiangli Wuhu Mixture in treating pneumonia might be related to lipopolysaccharide reaction and Toll-like receptor signaling pathway. the in vivo results indicated that Qiangli Wuhu Mixture had a strong protective effect on acute pneumonia in mice induced by lipopolysaccharide, decreased the levels of inflammatory factors TNF-α, IL-1β and IL-6 in serum of model mice, and decreased the activation of TLR4, NF- κ B, and the expression of NLRP3 protein in lung tissue. Conclusion: Qiangli Wuhu Mixture has a strong protective effect on lipopolysaccharide-induced pneumonia in mice, and its mechanism of action may be related to reducing the pathological changes of lung tissue, reducing the level of inflammatory cytokines in blood, and inhibiting the inflammatory signal pathway of TLR4/NF-κB/NLRP3.
The Mere Sight of Loved Ones Does Not Inhibit Psychophysiological Defense Mechanisms When Threatened
Authors: Bublatzky Florian , Schellhaas Sabine , Guerra Pedro 
Published: October 2021

Abstract
Looking at pictures of loved ones, such as one's romantic partner or good friends, has been shown to alleviate the experience of pain and reduce defensive reactions. However, little is known about such modulatory effects on threat and safety learning and the psychophysiological processes involved. Here, we explored the hypothesis that beloved faces serve as implicit safety cues and attenuate the expression of fear responses and/or accelerate extinction learning in a threatening context. Thirty-two participants viewed pictures of their loved ones (romantic partner, parents, and best friend) as well as of unknown individuals within contextual background colors indicating threat-of-shock or safety. Focusing on the extinction of non-reinforced threat associations (no shocks were given), the experiment was repeated on two more test days while the defensive startle-EMG, SCR, and threat ratings were obtained. Results confirmed pronounced defensive responding to instructed threat-of-shock relative to safety context (e.g., threat-enhanced startle reflex and SCR). Moreover, threat-potentiated startle response slowly declined across test days indicating passive extinction learning in the absence of shocks. Importantly, neither a main effect of face category (loved vs. unknown) nor a significant interaction with threat/safety instructions was observed. Thus, a long-term learning history of beneficial relations (e.g., with supportive parents) did not interfere with verbal threat learning and aversive apprehensions.
Normal Mode Analysis of The Thermal conductivity in Amorphous Polymers: The Importance of Localized Modes
Authors: Li Buxuan , DeAngelis Freddy , Chen Gang , Henry Asegun 
Published: October 2021

Abstract
Polymers are a unique class of materials from the perspective of normal mode analysis. Polymers consist of individual chains with repeating units and strong intra-chain covalent bonds, and amorphous arrangements among chains with weak inter-chain van der Waals and for some polymers also electrostatic interactions. Intuitively, this strong heterogeneity in bond strength can give rise to interesting features in the constituent phonons, but such effects have not been studied deeply before. Here, we use lattice dynamics and molecular dynamics to perform modal analysis of the thermal conductivity in amorphous polymers for the first time. We find an abnormally large population of localized modes in amorphous polymers, which is dramatically different from amorphous inorganic materials. Contrary to the common picture of thermal transport, localized modes in amorphous polymers are found to be the dominant contributors to thermal conductivity. We find that a significant portion of the localization happens within individual chains, but heat is dominantly conducted when localized modes involve two chains. These results suggest that even though each polymer is different, localized modes play a key role. The results provide new perspective on why polymer thermal conductivity is generally quite low and gives insight into how to potentially change it.