bluuebunny/crossref_metadata_2025_split huggingface dataset:
State-based targeted vaccination
Authors: Lev Tomer , Shmueli Erez 
Published: January 2021

AbstractVaccination has become one of the most prominent measures for preventing the spread of infectious diseases in modern times. However, mass vaccination of the population may not always be possible due to high costs, severe side effects, or shortage. Therefore, identifying individuals with a high potential of spreading the disease and targeted vaccination of these individuals is of high importance. While various strategies for identifying such individuals have been proposed in the network epidemiology literature, the vast majority of them rely solely on the network topology. In contrast, in this paper, we propose a novel targeted vaccination strategy that considers both the static network topology and the dynamic states of the network nodes over time. This allows our strategy to find the individuals with the highest potential to spread the disease at any given point in time. Extensive evaluation that we conducted over various real-world network topologies, network sizes, vaccination budgets, and parameters of the contagion model, demonstrates that the proposed strategy considerably outperforms existing state-of-the-art targeted vaccination strategies in reducing the spread of the disease. In particular, the proposed vaccination strategy further reduces the number of infected nodes by 23–99%, compared to a vaccination strategy based on Betweenness Centrality.
A proposal to determine the distribution of lateral forces from loaded recycled plastic drainage kerbs
Authors: O’Flaherty Fin , Al-Shawi Fathi 
Published: January 2021

AbstractThis study presents a detailed analysis of the lateral forces generated as a result of vertically applied loads to recycled plastic drainage kerbs. These kerbs are a relatively new addition to road infrastructure projects. When concrete is used to form road drainage kerbs, its deformation is minimum when stressed under heavy axle loads. Although recycled plastic kerbs are more environmentally friendly as a construction product, they are less stiff than concrete and tend to deform more under loading leading to a bursting type, lateral force being applied to the haunch materials, the magnitude of which is unknown. A method is proposed for establishing the distribution of these lateral forces resulting from deformation under laboratory test conditions. A load of 400 kN is applied onto a total of six typical kerbs in the laboratory in accordance with the test standard. The drainage kerbs are surrounded with 150 mm of concrete to the front and rear haunch and underneath as is normal during installation. The lateral forces exerted on the concrete surround as a result of deformation of the plastic kerbs are determined via a strain measuring device. Analysis of the test data allows the magnitude of the lateral forces to the surrounding media to be determined and, thereby, ensuring the haunch materials are not over-stressed as a result. The proposed test methodology and subsequent analysis allows for an important laboratory-based assessment of any typical recycled plastic drainage kerbs to be conducted to ensure they are fit-for-purpose in the field.
Characterizing Khetri copper mine environment using geospatial tools
Authors: Punia Anita , Joshi Pawan Kumar , Siddaiah Neelam Siva 
Published: January 2021

AbstractMines result in land use and land cover (LULC) change due to degradation of natural resources and establishment of new infrastructure for ore extraction and beneficiation. The present study was carried out to, with objectives, (1) characterize LULC change (from 1975 to 2017) in Khetri copper mine region, (2) spatial distribution of pollution indices and (3) spectral response of elemental concentration of soil and groundwater using Landstat and ASTER satellite data. The study was designed to fulfil the objectives and for the same NDVI values were calculated for LULC classification and generated maps were analyzed for landscape pattern. Spatial distribution of pollution indices calculated using geochemical data of soil and groundwater was plotted to understand the impact of contamination on landscape pattern. The correlation of spectral response of Landstat bands with heavy metals concentration was plotted to assess their possible use in quantification of heavy metals. Results show constant increase in settlements, mines and open area while vegetation cover has decreased. Landscape and class level metrics (number of patch, patch density, aggregation index and landscape shape index) indicate increase in the fragmentation of landscape in recent years. Shannon’s Evenness Index indicates increase in uniformity in landscape and it is attributed to loss of vegetation and agriculture patches. Pollution indices, Pollution Load Index for soil is high near the overburden materials and Index of Environmental Risk (IER) and Contamination Index for ground water is high near abandoned mines. Spectral bands 5 and 6 (SWIR 1) show significant negative correlation, and 9 (Cirrus) shows significant positive correlation with metal concentration in soil and water suggesting the possible use of remote sensing in assessment of metal concentration at ground level. Thus, it can be concluded that mines significantly influence the landscape pattern and remote sensing could be used for the assessment and predication of heavy metal contamination at broader scale in a cost-effective way.
Fish bone-derived interconnected carbon nanofibers for efficient and lightweight microwave absorption
Authors: Gu Yangyang , Dai Peng , Zhang Wen , Su Zhanwen 
Published: January 2021

AbstractIn this work, we demonstrated a simple method for preparing three-dimensional interconnected carbon nanofibers (ICNF) derived from fish bone as an efficient and lightweight microwave absorber. The as-obtained ICNF exhibits excellent microwave absorption performance with a maximum reflection loss of –59.2 dB at the filler content of 15 wt%. In addition, the effective absorption bandwidth can reach 4.96 GHz at the thickness of 2 mm. The outstanding microwave absorption properties can be mainly ascribed to its well-defined interconnected nanofibers architecture and the doping of nitrogen atoms, which are also better than most of the reported carbon-based absorbents. This work paves an attractive way for the design and fabrication of highly efficient and lightweight electromagnetic wave absorbers.
Effect of carrier volume and application method on waterhyacinth (Eichhornia crassipes) response to 2,4-D, glyphosate, and diquat
Authors: Sperry Benjamin P. , Ferrell Jason A. 
Published: January 2021

AbstractMesocosm studies were conducted in 2020 to evaluate the effects of carrier volume and application method on waterhyacinth [Eichhornia crassipes (Mart.) Solms] response to 2,4-D, glyphosate, and diquat. Carrier volumes of 935, 467, and 187 L ha−1 were applied using either a conventional stream, conventional cone, adjustable cone, or a drizzle-stream spray pattern. Reducing carrier volume from 935 L ha−1 reduced spray coverage up to 60%, depending on application method. However, reducing carrier volume did not diminish efficacy of any herbicide or application method. Alternatively, E. crassipes control from 2,4-D increased 10% to 26% when applied using 187 L ha−1 compared with 935 L ha−1. Likewise, E. crassipes biomass was reduced 91% when 2,4-D was applied using 935 L ha−1; however, treatment applied at 187 L ha−1 resulted in 99% biomass reduction. In general, 2,4-D resulted in roughly 10% greater control when conventional or adjustable cone applications were used compared with either stream applications. Eichhornia crassipes control at 7 d after treatment (DAT) from diquat increased with decreasing carrier volumes; however, treatment effects in diquat experiments were not detected at other evaluation intervals. Glyphosate efficacy was highly influenced by carrier volume, as E. crassipes control increased up to 61% when applied using 187 L ha−1 compared with 935 L ha−1. Moreover, E. crassipes biomass reduction increased from 55% in the 935 L ha−1 treatment to 97% in the 187 L ha−1 treatments. Glyphosate application methods consisting of conventional stream or conventional cone sprayers resulted in slightly increased E. crassipes control by 28 DAT; however, no differences among application methods were observed in E. crassipes biomass data. These data support further evaluations of alternative application techniques for E. crassipes control under field conditions and for other herbicides and aquatic plant species.
Effective suppression of established invasive Phragmites australis leads to secondary invasion in a coastal marsh
Authors: Robichaud Courtney D. , Rooney Rebecca C. 
Published: January 2021

AbstractInvasive species negatively impact vegetation communities. Invasive European common reed [Phragmites australis (Cav.) Trin. ex Steud. ssp. australis] is rapidly spreading throughout North American wetlands. As such, the suppression of P. australis populations is a goal of many managers, as its removal should provide an opportunity to restore native vegetation communities. In Ontario, managers applied a glyphosate-based herbicide to more than 400 ha of P. australis in ecologically significant coastal marshes, representing the first time this tool was used over standing water to suppress an invasive species in Canada. Using a before–after–control–impact monitoring design, we evaluated the efficacy of glyphosate-based herbicide at removing P. australis along a water-depth gradient and assessed the recovery of the vegetation community for 2 yr after treatment in relation to reference conditions. We found that herbicide suppressed more than 99% of P. australis 1 yr after treatment and worked effectively along the entire water-depth gradient (10 to 48 cm). However, the post-treatment vegetation community remains distinctive from reference marsh 2 yr after treatment. In many plots where P. australis was removed, nonnative European frog-bit (Hydrocharis morsus-ranae L.) is now dominant, likely aided by high lake-water levels.
Gender difference in the association of dietary intake of antioxidant vitamins with kidney function in middle-aged and elderly Japanese
Authors: Hara Akinori , Tsujiguchi Hiromasa , Suzuki Keita , Suzuki Fumihiko , Kasahara Tomoko , Oanh Pham Kim , Miyagi Sakae , Kannon Takayuki , Tajima Atsushi , Wada Takashi , Nakamura Hiroyuki 
Published: January 2021

Abstract
Dietary intake modification is important for the treatment of chronic kidney disease (CKD); however, little is known about the association between dietary intake of antioxidant vitamins and kidney function based on gender difference. We examined the relationship of dietary intake of antioxidant vitamins with decreased kidney function according to gender in Japanese subjects. This population-based, cross-sectional study included 936 Japanese participants with the age of 40 years or older. A validated brief self-administered diet history questionnaire was used to measure dietary intakes of vitamin E and its four isoforms, vitamin A and vitamin C. Decreased kidney function was defined as estimated glomerular filtration rate <60 ml/min/1·73 m2. A total of 498 (53·2 %) of the study participants were women. Mean age was 62·4 ± 11·3 years. Overall, 157 subjects met the criteria of decreased kidney function. In the fully adjusted model, a high vitamin E intake is inversely associated with decreased kidney function in women (odds ratio, 0·886; 95 % confidence interval, 0·786–0·998), whereas vitamin E intake was not associated with decreased kidney function (odds ratio, 0·931; 95 % confidence interval, 0·811–1·069) in men. No significant association between dietary intake of vitamins A and C and decreased kidney function was observed in women and men. Higher dietary intake of vitamin E was inversely associated with decreased kidney function in middle-aged and older women, and the result may provide insight into the more tailored dietary approaches to prevent CKD.
Morphological conservatism of the family Naticidae (Gastropoda) through time: potential causes and consequences
Authors: Sharma Neha , Mondal Subhronil , Das Shiladri S. , Bose Kanishka , Saha Sandip 
Published: January 2021

AbstractTaxonomic status of several members of the family Naticidae is extremely vague because of its simple shell morphology. Conventional taxonomic classification schemes suggest that most of the morphological characters tend to be homoplastic and exhibit convergence. Such morphological convergence complicates naticid taxonomy and makes it difficult to understand the evolutionary history of this group; several unrelated taxa are often misidentified as naticids, thereby exaggerating the actual diversity of this group. Here, we employ a standard landmark-based approach to understand the pattern of morphological evolution of this family. Ordination methods such as principal components analysis and canonical variate analysis were used to create morphospaces, and disparity was quantified using variance and range. Our results reveal that when naticids are compared with their sister taxon, Ampullinidae, the two families show significant differences in their average shapes, despite their superficial resemblances. Among naticids, although the mean shapes of the individual subfamilies are different, overall, the family Naticidae has displayed extreme morphological conservatism from the Jurassic to the Holocene. Interestingly, this conservatism has been unaffected by taxonomic changes—neither the extinction of the subfamily Gyrodinae nor the appearance of the subfamily Sininae affected this morphological conservatism. Naticids have always shown strong ecological preference toward an infaunal mode of life and strict behavioral selectivity in handling and preying upon infaunal organisms, and this ecological and behavioral conservatism could have enabled them to diversify without undergoing a change in their basicBauplan.
Intensive Betreuungen dokumentieren
Authors: Nienaber André , Franz Shiney , Chu Simon 
Published: January 2021

﻿Was ist zu diesem Thema bereits bekannt?﻿ Intensivbetreuungen kommen in der Begleitung von Personen in psychiatrischen Krisen immer wieder vor und haben das Ziel, Patient_innen in extremen Ausnahmesituationen zu schützen und zu unterstützen. Wie wird eine neue Perspektive eingebracht? MSORT ist ein „Tool“, ein Werkzeug in Form einer Checkliste für die psychiatrische Praxis zur Unterstützung und Verbesserung der Dokumentation und Kommunikation von Intensivbetreuungen. Was sind die Auswirkungen für die Praxis? Im besten Fall unterstützt MSORT die Dokumentation der intensiven Betreuung und fördert auf diese Weise auch die Kommunikation der Maßnahme, sowohl in der direkten Patientenversorgung als auch im multiprofessionellen Team.
Targeting the ubiquitination/deubiquitination process to regulate immune checkpoint pathways
Authors: Liu Jiaxin , Cheng Yicheng , Zheng Ming , Yuan Bingxiao , Wang Zimu , Li Xinying , Yin Jie , Ye Mingxiang , Song Yong 
Published: January 2021

AbstractThe immune system initiates robust immune responses to defend against invading pathogens or tumor cells and protect the body from damage, thus acting as a fortress of the body. However, excessive responses cause detrimental effects, such as inflammation and autoimmune diseases. To balance the immune responses and maintain immune homeostasis, there are immune checkpoints to terminate overwhelmed immune responses. Pathogens and tumor cells can also exploit immune checkpoint pathways to suppress immune responses, thus escaping immune surveillance. As a consequence, therapeutic antibodies that target immune checkpoints have made great breakthroughs, in particular for cancer treatment. While the overall efficacy of immune checkpoint blockade (ICB) is unsatisfactory since only a small group of patients benefited from ICB treatment. Hence, there is a strong need to search for other targets that improve the efficacy of ICB. Ubiquitination is a highly conserved process which participates in numerous biological activities, including innate and adaptive immunity. A growing body of evidence emphasizes the importance of ubiquitination and its reverse process, deubiquitination, on the regulation of immune responses, providing the rational of simultaneous targeting of immune checkpoints and ubiquitination/deubiquitination pathways to enhance the therapeutic efficacy. Our review will summarize the latest findings of ubiquitination/deubiquitination pathways for anti-tumor immunity, and discuss therapeutic significance of targeting ubiquitination/deubiquitination pathways in the future of immunotherapy.
ADO/hypotaurine: a novel metabolic pathway contributing to glioblastoma development
Authors: Shen Dachuan , Tian Lili , Yang Fangyu , Li Jun , Li Xiaodong , Yao Yiqun , Lam Eric W.-F. , Gao Peng , Jin Bilian , Wang Ruoyu 
Published: January 2021

AbstractSignificant advance has been made towards understanding glioblastoma metabolism through global metabolomic profiling. However, hitherto little is known about the role by which altered metabolism plays in driving the aggressive glioma phenotype. We have previously identified hypotaurine as one of the top-ranked metabolites for differentiating low- and high-grade tumors, and that there is also a strong association between the levels of intratumoral hypotaurine and expression of its biosynthetic enzyme, cysteamine (2-aminoethanethiol) dioxygenase (ADO). Using transcription profiling, we further uncovered that the ADO/hypotaurine axis targets CCL20 secretion through activating the NF-κB pathway to drive the self-renewal and maintenance of glioma ‘cancer stem cells’ or glioma cancer stem-like cells. Conversely, abrogating the ADO/hypotaurine axis using CRISPR/Cas9-mediated gene editing limited glioblastoma cell proliferation and self-renewal in vitro and tumor growth in vivo in an orthotopical mouse model, indicating that this metabolic pathway is a potential key therapeutic target. Collectively, our results unveil a targetable metabolic pathway, which contributes to the growth and progression of aggressive high-grade gliomas, as well as a novel predictive marker for glioblastoma diagnosis and therapy.
High spin mixing conductance and spin interface transparency at the interface of a Co2Fe0.4Mn0.6Si Heusler alloy and Pt
Authors: Singh Braj Bhusan , Roy Koustuv , Gupta Pushpendra , Seki Takeshi , Takanashi Koki , Bedanta Subhankar 
Published: January 2021

AbstractFerromagnetic materials exhibiting low magnetic damping (α) and moderately high-saturation magnetization are required from the viewpoints of generation, transmission, and detection of spin waves. Since spin-to-charge conversion efficiency is another important parameter, high spin mixing conductance $$({g_{r}^{\uparrow \downarrow}})$$

(

g

r

↑
↓

)

is the key for efficient spin-to-charge conversion. Full Heusler alloys, e.g., Co2Fe0.4Mn0.6Si (CFMS), which are predicted to be 100% spin-polarized, exhibit low α. However, $$g_r^{ \uparrow \downarrow }$$

g

r

↑
↓

at the interface between CFMS and a paramagnet is not fully understood. Here, we report investigations of spin pumping and the inverse spin Hall effect in CFMS/Pt bilayers. Damping analysis indicates the presence of significant spin pumping at the interface of CFMS and Pt, which is also confirmed by the detection of an inverse spin Hall voltage. We show that in CFMS/Pt, $$g_r^{ \uparrow \downarrow }$$

g

r

↑
↓

(1.70 × 1020 m−2) and the interface transparency (83%) are higher than the values reported for other ferromagnetic/heavy metal systems. We observed a spin Hall angle of ~0.026 for the CFMS/Pt bilayer system.
AutoMap is a high performance homozygosity mapping tool using next-generation sequencing data
Authors: Quinodoz Mathieu , Peter Virginie G. , Bedoni Nicola , Royer Bertrand Béryl , Cisarova Katarina , Salmaninejad Arash , Sepahi Neda , Rodrigues Raquel , Piran Mehran , Mojarrad Majid , Pasdar Alireza , Ghanbari Asad Ali , Sousa Ana Berta , Coutinho Santos Luisa , Superti-Furga Andrea , Rivolta Carlo 
Published: January 2021

AbstractHomozygosity mapping is a powerful method for identifying mutations in patients with recessive conditions, especially in consanguineous families or isolated populations. Historically, it has been used in conjunction with genotypes from highly polymorphic markers, such as DNA microsatellites or common SNPs. Traditional software performs rather poorly with data from Whole Exome Sequencing (WES) and Whole Genome Sequencing (WGS), which are now extensively used in medical genetics. We develop AutoMap, a tool that is both web-based or downloadable, to allow performing homozygosity mapping directly on VCF (Variant Call Format) calls from WES or WGS projects. Following a training step on WES data from 26 consanguineous families and a validation procedure on a matched cohort, our method shows higher overall performances when compared with eight existing tools. Most importantly, when tested on real cases with negative molecular diagnosis from an internal set, AutoMap detects three gene-disease and multiple variant-disease associations that were previously unrecognized, projecting clear benefits for both molecular diagnosis and research activities in medical genetics.
Point-to-point stabilized optical frequency transfer with active optics
Authors: Dix-Matthews Benjamin P. , Schediwy Sascha W. , Gozzard David R. , Savalle Etienne , Esnault François-Xavier , Lévèque Thomas , Gravestock Charles , D’Mello Darlene , Karpathakis Skevos , Tobar Michael , Wolf Peter 
Published: January 2021

AbstractTimescale comparison between optical atomic clocks over ground-to-space and terrestrial free-space laser links will have enormous benefits for fundamental and applied sciences. However, atmospheric turbulence creates phase noise and beam wander that degrade the measurement precision. Here we report on phase-stabilized optical frequency transfer over a 265 m horizontal point-to-point free-space link between optical terminals with active tip-tilt mirrors to suppress beam wander, in a compact, human-portable set-up. A phase-stabilized 715 m underground optical fiber link between the two terminals is used to measure the performance of the free-space link. The active optical terminals enable continuous, cycle-slip free, coherent transmission over periods longer than an hour. In this work, we achieve residual instabilities of 2.7 × 10−6 rad2 Hz−1 at 1 Hz in phase, and 1.6 × 10−19 at 40 s of integration in fractional frequency; this performance surpasses the best optical atomic clocks, ensuring clock-limited frequency comparison over turbulent free-space links.
Molecular embroidering of graphene
Authors: Wei Tao , Kohring Malte , Weber Heiko B. , Hauke Frank , Hirsch Andreas 
Published: January 2021

AbstractStructured covalent two-dimensional patterning of graphene with different chemical functionalities constitutes a major challenge in nanotechnology. At the same time, it opens enormous opportunities towards tailoring of physical and chemical properties with limitless combinations of spatially defined surface functionalities. However, such highly integrated carbon-based architectures (graphene embroidery) are so far elusive. Here, we report a practical realization of molecular graphene embroidery by generating regular multiply functionalized patterns consisting of concentric regions of covalent addend binding. These spatially resolved hetero-architectures are generated by repetitive electron-beam lithography/reduction/covalent-binding sequences starting with polymethyl methacrylate covered graphene deposited on a Si/SiO2 substrate. The corresponding functionalization zones carry bromobenzene-, deutero-, and chloro-addends. We employ statistical Raman spectroscopy together with scanning electron microscopy/energy dispersive X-ray spectroscopy for an unambiguous characterization. The exquisitely ordered nanoarchitectures of these covalently multi-patterned graphene sheets are clearly visualized.