bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric properties of the Persian translation of Maternal Postpartum Quality of Life Questionnaire(MAPP-QOL).
Authors: Tahereh Mokhtarian-Gilani , Ozgoli Gity , Kariman Nourossadat , Hamid Sharif Nia , Doulabi Mahbobeh Ahmadi , Malihe Nasiri 
Published: January 2021

Abstract
Background and Objective: Many studies have been conducted in Iran on the postpartum quality of life, and the majority have used the general quality of life questionnaire. With a specific tool in this context, the dimensions of maternal postpartum quality of life can be more accurately determined. The present study was conducted to determine psychometric properties and validate the Persian version of the Maternal Postpartum Quality of Life Questionnaire (MAPP-QOL).Materials and Methods: The present methodological study was conducted in 2018. The original version of MAPP-QOL was translated into Persian by both forward and backward translation. In a cross-sectional study, the Persian version was completed by 407 eligible postpartum women aged 18 to 47 and living in Tehran. Reliability of the questionnaire was assessed using Cronbach's alpha coefficient and test-retest. For construct validity, exploratory and confirmatory factor analyses were used.Results: The MAPP-QOL showed good content validity; content validity ratio (CVR) ranged from 0.6 to 1.00, and content validity index (CVI) ranged from 0.7 to 1.00. Using exploratory factor analysis, five factors, including Socioeconomic; Relational/Family-Friends; Psychological/Baby; Health & functioning; and Relational/Spouse-Partner, were extracted, which together explained 78.84% of the total variance. After modifications of CFA, the confirmatory factor analysis showed an acceptable goodness-of-fit. AVE value Above 0.5 exhibited appropriate convergent validity, and AVE greater than MSV confirmed divergent validity. The Cronbach's alpha, McDonald's Omega, Composite reliability and maximum reliability H of the five extracted factors were excellent (>0.9). Also, the AIC values of the factors were good (between 0.721 to 0.859). Conclusion: The 38-item Persian version of the postpartum quality of life questionnaire is adequately reliable for postpartum women in Iran. Given its appropriate psychometric properties, this scale is fit to be used in future studies on postpartum women.
Calcification-driven CO2 emissions exceed “Blue Carbon” sequestration in a carbonate seagrass meadow
Authors: Dam Bryce Van , Zeller Mary , Lopes Christian , Smyth Ashley , Böttcher Michael , Osburn Christopher , Zimmerman Tristan , Pröfrock Daniel , Fourqurean James , Thomas Helmuth 
Published: January 2021

Abstract
Long-term “blue carbon” burial in seagrass meadows is complicated by other carbon and alkalinity exchanges that shape net carbon sequestration. We measured a suite of such processes, including denitrification, sulfur, and inorganic carbon cycling, and assessed their impact on air-water carbon dioxide exchange in a typical seagrass meadow underlain by carbonate sediments. Contrary to the prevailing concept of seagrass meadows acting as carbon sinks, eddy covariance measurements reveal this ecosystem as a consistent source of carbon dioxide to the atmosphere, at an average rate of 610 ± 990 µmol m-2 hr-1 during our study and 700 ± 660 µmol m-2 hr-1 over an annual cycle. A robust mass-balance shows that net alkalinity consumption by ecosystem calcification explains >95% of the observed carbon dioxide emissions, far exceeding alkalinity generated by net reduced sulfur, iron and organic carbon burial. Isotope geochemistry of porewaters suggests substantial dissolution and re-crystallization of more stable carbonates mediated by sulfide oxidation-induced acidification, enhancing long-term carbonate burial and ultimate carbon dioxide production. We show that the “blue carbon” sequestration potential of calcifying seagrass meadows has been over-estimated, and that in-situ organic carbon burial only offsets a small fraction (<5%) of calcification-induced CO2 emissions. Ocean-based climate change mitigation activities in such calcifying regions should be approached with caution and an understanding that net carbon sequestration may not be possible.
Interpersonal Counselling Versus Perinatal-specific Cognitive Behavioural Therapy for Women with Depression during Pregnancy Offered in Routine Psychological Treatment Services: A Phase II Trial.
Authors: Evans Jonathan , Ingram Jenny , Law Roslyn , Taylor Hazel , Johnson Debbie , Glynn Joel , Hopley Becky , Kessler David , Round Jeff , Ford Jenny , Culpin Iryna , O'Mahen Heather 
Published: January 2021

Abstract
Background Up to one in eight women experience depression during pregnancy. In the UK, low intensity cognitive behavioural therapy (CBT) is the main psychological treatment offered for those with mild or moderate antenatal depression, but has limited relevance to the perinatal context. Referral by midwives and take up of treatment by pregnant women is extremely low. Interpersonal Counselling (IPC) is a brief, low-intensity form of Interpersonal Psychotherapy (IPT) that focuses on areas of concern to service users during pregnancy.To improve psychological treatment for depression during pregnancy, the study aimed to assess the feasibility and acceptability of a trial of IPC for antenatal depression in routine NHS services compared to low intensity perinatal specific CBT.Methods. We conducted a small randomised controlled trial in two centres. A total of 52 pregnant women with mild or moderate depression were randomised to receive 6 sessions of IPC or perinatal specific CBT. Treatment was provided by 12 junior mental health workers (jMHW). The primary outcome was the number of women recruited to the point of randomisation. Secondary outcomes included maternal mood, couple functioning, attachment, functioning, treatment adherence, and participant and staff acceptability. Results. The study was feasible and acceptable. Recruitment was successful through scanning clinics, only 6 of the 52 women were recruited through midwives. Treatment competence by jMHWs was high. 71% of women in IPC completed treatment. Women reported IPC was acceptable, and supervisors reported high treatment fidelity in IPC therapists. Outcome measures indicated there was improvement in mood in both groups (Change in EPDS score IPC 4.4 (s.d. 5.1) and CBT 4.0 (s.d. 4.8).Conclusions. This was a feasibility study and was not large enough to detect important differences between IPC and perinatal specific CBT. A full-scale trial of IPC for antenatal depression in routine IAPT services is feasible.Trial registrationThis study has been registered with ISRCTN registry 11513120. – date of registration 05/04/2018. https://doi.org/10.1186/ISRCTN11513120
SART1 localizes to spindle poles forming a SART1 cap and promotes centrosome and spindle assembly
Authors: Yokoyama Hideki , Takizawa Kaoru , Ma Jian , Moreno-Andrés Daniel , Antonin Wolfram , Haramoto Yoshikazu 
Published: January 2021

Abstract
SART1 is overexpressed in various cancers. However, its physiological function and cancer relevance remains elusive. Here we identify SART1 as a mitotic-specific and Ran-regulated microtubule-associated protein. SART1 downregulation in human cells as well as its depletion from frog egg extracts disrupts spindle assembly. While SART1 is nuclear in interphase, it localizes during mitosis to spindle poles in a microtubule-dependent manner. SART1 accumulates close to centrosomes forming a half circle which we designate as SART1 cap. Immunoprecipitation of SART1 identifies the centrosome scaffold protein Cep192 as an interaction partner. Accordingly, Cep192 downregulation abolishes SART1 localization to spindle poles, and SART1 downregulation displaces centrosomal proteins like Ninein from centrosomes, but does not affect γ-tubulin localization. Furthermore, SART1 downregulation selectively kills cancer cells and prevents normal cells from oncogenic transformation. Our data unravel a novel function of SART1 for centrosome organization and spotlight SRAT1 as a potential target for anticancer therapies.
Predictive Value of Electrocardiogram for the Occurrence of Major Adverse Cardiac Events in Patients with Pulmonary Embolism
Authors: Salimi Farahnnaz , Javanshir Elnaz , Sadat-Ebrahimi Seyyed-Reza , Meshgi Shahla , Ghaffari Samad 
Published: January 2021

Abstract
Background

Pulmonary embolism (PE) is one of the most prevalent cardiovascular diseases worldwide. A few studies have advocated the applicability of electrocardiogram (ECG) for the determination of prognosis of PE patients. Considering the low-cost and wide availability of ECG we aimed to investigate the association of selected ECG parameters with the occurrence of major adverse cardiac events (MACE) in PE patients.
Methods

In this study, 733 adult patients admitted with a definite diagnosis of acute PE were included from a registry of PE patients in a tertiary heart center. The patients’ clinical records were retrospectively reviewed, and demographic information, ECG abnormalities as well as the data on MACE (including hypotension, mechanical ventilation, Syncope, cardiogenic shock, or in-hospital mortality) were extracted.
Results

A total of 177 patients (24.1%) had MACE. Right bundle branch block (RBBB), incomplete RBBB, S1Q3T3, ST elevation in leads V1 or III, QR wave in lead V1, and inverted T wave in lead V1 to V4 were more frequently detected in the ECGs of patients who developed MACE (P values = 0.006, 0.030, 0.001, 0.001, 0.042, 0.001, and 0.001, respectively). The results of multivariate regression analysis demonstrated that ST-elevation in aVR (OR = 3.87, 95%CI = 2.32–6.44, P = 0.001) and S1Q3T3 (OR = 2.04, 95%CI = 1.22–3.43, P = 0.007) were independent predictors of MACE in PE patients. The sensitivities of ST elevation in the aVR lead and S1Q3T3 were 53.1% and 59.9%, and specificities were 79.7% and 68.1%, respectively.
Conclusion

Some ECG parameters including S1Q3T3 and ST elevation in aVR are independent predictors of MACE in patients with PE. Investigating these parameters in ECG can be helpful in the determination of the prognosis of PE patients.
Atractylodes Lancea Volatile Oils Target ADAR2-miR-181a-5p Signaling to Mesenchymal Stem Cells Chondrogenic Differentiation
Authors: Ye Shanyu , Si Wenwen , Qin Wei , Luo Ziwei , Li Zhen , Xie Yulu , Pan Hao , Li Xinrong , Huang Zifeng , Chen Dongfeng 
Published: January 2021

Abstract
Background：The Rhizoma Atractylodis has long been recommended for the treatment of different diseases in traditional Chinese medicine. The main component of Rhizoma Atractylodis is Atractylodes lancea volatile oils which possesses anti-microorganism, anti-tumor, cognitive protection and immunoregulation. The aim of the study was to elucidate the mechanism of Atractylodes lancea volatile oils promoting mesenchymal stem cells (MSCs) chondrogenic differentiation. Method：Atractylodes lancea volatile oils were extracted from Chinese medicine Cangzhu by volatile oil extractor. MSCs culture were treated with Atractylodes lancea volatile oils medium. Real-time reverse transcription PCR was conducted to verify the candidate microRNAs discovered by microarray analysis. Western-blot analyzed the expressions of mark genes. Sanger sequences identified the changes of the base pairs which would be edited by ADAR2 enzyme. Toluidine blue staining identified the changes of cells chondrogenic differentiation. Result：Treatment of Atractylodes lancea volatile oils increased the cells chondrogenic differentiation of MSCs. Atractylodes lancea volatile oils promoted the expression of ADAR2 enzyme which may edit the precursor of miR-181a-5p. A dual luciferase reporter system assay verified that transcription factors yingyang1(YY1) was targeted by miR-181a-5p which was downregulated in MSCs chondrogenic differentiation. Conclusion：This work demonstrates the mechanism of Atractylodes lancea volatile oils promoting MSCs to chondrogenic differentiation. It may provide an alternative strategy for treatment purposes and diagnosis in clinic.
Differential Expression of Toll-Like Receptors 1 and 3 in Patients With Systemic Lupus Erythematosus and Systemic Sclerosis
Authors: Liu Ang-Jun , Wu Po-Chang , Ciou Jian-Ruei , Hou Pu-Wei , Huang Chung-Ming , Huang Po-Hao , Chen Yu-Pei , Chu Hsueh-Ting , Chang Hen-Hong 
Published: January 2021

Abstract
Background: Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) are autoimmune diseases with some overlapping clinical manifestations. Recent studies have revealed that Toll-like receptors (TLRs) play essential roles in autoimmune diseases' pathogenesis. To investigate the expression of TLR genes in SLE and SSc that are specific to the character of these diseases' pathogenesis.Methods: We recruited patients with SLE (n = 15) and SSc (n = 9) from China Medical University Hospital hospital in Taiwan from 2016 to 2017. Included were healthy reference controls and SLE datasets from the NCBI database. RNA was extracted from peripheral blood cells of the patients for next-generation sequencing (NGS). Results in identified differentially expressed genes were compared to explore TLRs' association with SLE and SSc pathogenesis. Housekeeping genes, including ACTB, GAPDH, PGK1, PPIB, SDHA, and TBP, were used to normalize the expression levels of the TLR genes. Results: There were significant differences in raw gene expression for patients with SLE and SSc (p < 0.05). No significant difference between patients with SLE and control datasets with SLE (p >0.05). The expression levels of TLR1 (p = 0.018) and TLR3 (p = 0.031) were significantly upregulated in the patients with SSc compared with those with SLE, normalized by GAPDH. Compared with many housekeeping genes, ACTB, GAPDH, and TBP indicated a significant difference (p < 0.05) in the expression of TLR1and TLR3. Conclusions: TLR1 and TLR3 can serve as biomarkers to distinguish the gene expression between SLE and SSc, normalized with housekeeping genes such as ACTB, GADPH, and TBP.
Consumption of OLL1073R-1 Yogurt Improves Psychological Quality of Life in Women Healthcare Workers: A Randomized Controlled Trial
Authors: Kinoshita Tetsu , Maruyama Koutatsu , Suyama Keiko , Nishijima Mariko , Akamatsu Kimiko , Jogamoto Akiko , Katakami Kikumi , Saito Isao 
Published: January 2021

Abstract
Background To investigate the effects of yogurt consumption fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 on improving mental quality of life of women healthcare workers, a randomized controlled trial was conducted. The 961 women (mainly nurses, aged 20–71 years) agreed to participate in this trial, and were randomly allocated to either the yogurt group (n = 479) or the control group (n = 482). Participants of the yogurt group drank 112 mL of OLL1073R-1 yogurt for 16 weeks, meanwhile those of the control group did not consume the yogurt. All participants were prohibited from consuming other yogurt or fermented dairy products during the study period. The participants answered the Pittsburgh Sleep Quality Index (PSQI), Short Form-8 Health Survey (SF-8), and Gastrointestinal Symptom Rating Scale (GSRS) questionnaires at baseline and after 16 weeks.Results The PSQI score showed significant improvement after the intake of yogurt (p < 0.01). SF-8 results showed significant intervention effects in the General Health and Vitality scores (p = 0.02 and p = 0.01, respectively). In other subscales of SF-8, we did not observe significant effects of the yogurt. In the GSRS, daily intake of the yogurt exerted a preventive effect on constipation (p = 0.03). Conclusions Consumption of yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 enhances subjective psychological quality of life by improving quality of sleep and gastrointestinal condition among women healthcare workers.
Structure–function Relationship and Vision-related Quality of Life in Glaucoma Secondary to Anterior Uveitis: Comparison with Open Angle Glaucoma
Authors: Choi Jin A , Lee Ji-Young , La Tae Yoon , Kim Jin-Ho 
Published: January 2021

Abstract
Uveitis is the most common inflammatory ocular disorder and frequently complicated by glaucoma, which is an important cause of irreversible sight loss. Inflammatory nature of the disease and widely fluctuating of intraocular pressure may affect visual function in patients with uveitis complicated by glaucoma. Therefore, we investigated the structure − function relationship and vision-related quality of life (VR-QoL) in 69 patients with uveitic glaucoma (UG), compared with 138 patients with primary open-angle glaucoma (OAG) using 25-item National Eye Institute Visual Function Questionnaire (VFQ-25). In a generalized linear model including age and corresponding structural metrics, the UG eyes had significantly lower mean deviation (MD) of the whole visual field (VF) and superior VF than the OAG eyes (p = 0.012 and 0.040). Patients with UG showed significantly lower composite score and 5 subscales of the VFQ-25, compared with those with OAG (p < 0.05, for all). In the OAG group, the composite score showed strongest associations with the whole binocular integrated VF (β = 1.156, p < 0.001), whereas in the UG group, a significant association was seen only with the inferior VF of the affected eye (β = 0.747, p = 0.005). In conclusion, eyes with UG exhibited a distinctive structure–function relationship and worse VR-QoL that differentiated them from OAG eyes.
Metagenomic Next-Generation Sequencing Improves The Prognosis of Patients With Infectious Diseases on Mechanical Ventilation in The Intensive Care Unit (ICU)
Authors: Xi Yin , Zhou Jing , Lin Zhimin , Liang Weibo , Yang Chun , Liu Dongdong , Xu Yonghao , Nong Lingbo , Chen Sibei , Yu Yuheng , He Weiqun , Zhang Jie , Zhang Rong , Pan Ying , Pan Jieyi , Li Jianchun , Chen Qiang , Liu Xiaoqing , Sang Ling , Xu Yuanda , Li Yimin 
Published: January 2021

Abstract
Background: Metagenomic Next-Generation Sequencing (mNGS) has gradually shown its advantages in pathogen identification for clinical infectious disease. However, few studies were conducted on the evaluation between this technique and conventional methods like culture and PCR and the prognosis of patients with infectious diseases on mechanical ventilation in ICUMethods: We conducted this retrospective study from March 2018 to May 2020 in the first Affiliated Hospital of Guangzhou Medical University, a total of 228 patients with suspected infectious diseases on mechanical ventilation were included, including 104 cases of mNGS group and 124 cases of non-mNGS. Statistical analyses were performed between the two groups and subgroup of whether were immunocompromised. The concordance between mNGS, culture and PCR was also assessed.Results: The 28-day mortality rate of the patients in the mNGS group was lower after the baseline difference correction (19.23% vs. 29.03%，p=0.039), indicating that mNGS may improve the prognosis of patients in ICU. And subgroup analysis showed that mNGS could improve the 28-day mortality of nonimmunosuppressive patients（14.06% vs. 29.82%, p=0.018）. According to the analysis of Logistic Regression, not performing mNGS, high APACHE II score and hypertension were independent risk factors for 28-day mortality, which strongly suggested that mNGS was one of the key factors affecting prognosis. A total of 157 samples performed mNGS, 116 of them received both mNGS and culture. mNGS presented advantages of positivity (69.8% double positive and 25.0% mNGS positive only) and concordance (79.0%, match and partly match).Conclusions: mNGS may improve the prognosis and reduce the 28-day mortality rate of patients with infectious diseases on mechanical ventilation in ICU. This technique has shown its advantages comparing with conventional methods, and will be wildly used as a promising technology for infectious disease.
Mean Muscle Attenuation within Paraspinal Muscle as a Determinant of Survival in Patients with Gastric Cancer Undergoing Gastrectomy
Authors: An Soomin , Eo Wankyu , Kim YounJung 
Published: January 2021

Abstract
Background: This study aimed to evaluate the prognostic potential of skeletal muscle mass and muscle quality at the level of the third lumbar vertebra (L3) using computerized tomography (CT) images in patients with stage I–III gastric cancer (GC) who underwent curative gastric resection.Methods: Patients with stage I–III GC who underwent curative gastric resection between October 2006 and June 2014 were enrolled in this study. Demographic and clinical parameters were collected and analyzed. The muscle-related parameters (MRPs), such as the area of total abdominal wall musculature (SMA), area of paraspinal muscle (PMA), mean muscle attenuation (MA) within the total abdominal wall musculature (SMMA), and MA in the paraspinal muscle (PMMA), were measured at the L3 level using CT images. The Kaplan-Meier curve analyses and Cox proportional hazards model were applied to the MRPs, demographic, and clinical parameters to explore the overall survival (OS) and disease-free survival (DFS).Results: Overall, data from 339 patients (233 men and 116 women) were analyzed in this study. In the multivariate Cox model, the elderly (hazard ratio [HR] 2.08, 95% confidence interval [CI] 1.30–3.32, p=0.002), total gastrectomy (HR 2.14, 95% CI 1.32–3.48, p=0.002), stage (HR 3.41, 95% CI 2.10–5.54, p<0.001), perineural invasion (HR 2.01, 95% CI 1.02–3.93, p=0.042), prognostic nutritional index (PNI) (HR 0.91, 95% CI 0.88–0.95, p<0.001), and PMMA (HR 2.36, 95% CI 1.47–3.78), p<0.001) were prognostic factors for OS. Similarly, the elderly (HR 1.68, 95% CI 1.09–2.59, p=0.018), total gastrectomy (HR 2.16, 95% CI 1.37–3.38, p<0.001, stage (HR 4.16, 95% CI 2.64–6.54, p<0.001), PNI (HR 0.91, 95% CI 0.87–0.94, p<0.001), and PMMA (HR 2.22, 95% CI 1.42–3.47, p<0.001) were prognostic factors for DFS.Conclusions: PMMA is suggested as a determinant of OS and DFS in stage I through III GC patients who underwent gastrectomy. Because PMMA is a newly characterized parameter in GC, external validation before clinical applications is a prerequisite.
Assessment and Predicting of LULC by Kappa Analysis and CA Markov model using RS and GIS Techniques in Udham Singh Nagar District, India
Authors: ARUMUGAM THANGAVELU , YADAV RAM LAKHAN , KINATTINKARA SAPNA 
Published: January 2021

Abstract
In this study an attempt to generate the LULC maps and investigate change detection analysis over a period of 22 years using Landsat satellite images of 1994, 2000, and 2016 and to predict the LULCC for the year 2016-2032 using CA Markov model in Udham Singh Nagar district, Uttarkhand. Satellite images of Landsat 5 TM, Landsat 7 ETM+, and Landsat 8 OLI sensor of nominal spatial resolution 30m were used. Supervised image classifications with the help of parallel pipe algorithm were used in this study. The validity of the Cellular Automata Markov model were used to predict future (16 years) LULC of 2032. The estimation includes two modules to predict the future land use pattern of the study area such as MARKOV and CA-MARKOV model/modules. Commonly, the accuracy of the classification results is assessed by the error matrix calculation. The result of overall change detection indicates agriculture, forest, water body and fallow land are decreased by 121.75 Km2 (14%), 44.70 Km2 (5%), 38.91 Km2 (4.5%) and 230.71 (26.5%); settlement and river sand are increased by 379.89 Km2 (44%) and 56.18 Km2 (6%). The study has an overall classification accuracy 76.84%, and standard kappa coefficient value (K) of 0.722. The model predicts the future change detection in agriculture 32%, forest 38%, fallow land 5%, settlement 20%, water body 3%, and river sand is 2%. This study is very effective for future LULC prediction that is helpful in urban development planning and the ﬁeld of management of natural resources.