bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Protective Effects of Single-Dose infusion of Warm Blood Cardioplegic Solution in a mini-pig model on the background of intraoperative anemia
Authors: Yavorovskiy Andrey G. , Komarov Roman N. , Kogan Evgenia A. , Mandel Irina A. , Panov Alexander V. , Bagdasarov Pavel S. , Bulanova Ekaterina L. , Khalikova Elena Yu. , Popov Alexander M. 
Published: July 2021

AbstractObjectivesThe tolerable ischemic time for many cardioplegia solutions has not been established yet. The aim of this study was to estimate the effect of a single-dose of cardioplegia solution Normacor (solution No. 1) and to establish the tolerable ischemic time in a normothermic cardiopulmonary bypass mini-pig model on the background of intraoperative anemia.MethodsFive female mini-pigs (34±3 kg, 6-month-old) were subjected to 180 min or 210 min of cardiac arrest by single-dose 400 ml Normacor cardioplegia (solution No. 1). A needle biopsy was taken from the left ventricle before the aortic cross-clamping and every 30 minutes after it. The restoration of left ventricle contractility was assessed by the clinical indicators, catecholamine support, morphological and immunohistochemical examination.ResultsThe morphological signs of cardiomyocytes ischemia were found after 120 minutes of aortic cross-clamping. According to the content of succinate dehydrogenase and hypoxia-inducible factor, the signs of the cardiomyocytes ischemic injury onset were detected at the same time point. During the entire period of aortic cross-clamping atrial activity was observed in all cases. The proposed single-dose ischemic time for re-dosing of cardioplegia is 120 minutes or ventricular activity onset.ConclusionsSafe and effective cardioprotection can be achieved with warm blood cardioplegia Normacor (solution No. 1) within 120 minutes for a single-dose infusion.Graphical Abstract
Fatty Alcohols, a Minor Component of the Tree Tobacco Surface Wax, Reduce Insect Herbivory
Authors: Negin Boaz , Shachar Lior , Meir Sagit , Ramirez Claudio C. , Horowitz A. Rami , Jander Georg , Aharoni Asaph 
Published: July 2021

AbstractDespite decades of research resulting in a comprehensive understanding of epicuticular wax biosynthesis and metabolism, the function of these almost ubiquitous metabolites in plant-herbivore interactions remains unresolved. To develop a better understanding of this role, we investigated plant-herbivore interactions in four Nicotiana glauca (tree tobacco) genome edited mutants. This included [eceriferum1 (cer1), eceriferum3 (cer3), β-ketoacyl-coA synthase6 (kcs6), and fatty acyl-coA reductase (far)] displaying a wide range of alkane and fatty alcohol abundances. Three interaction classes were examined: chewing herbivory with seven caterpillar and one snail species, phloem feeding with Myzus persicae (green peach aphid), and egg laying with Bemisia tabaci (sweet potato whitefly). We found that high wax load and alkane abundance did not reduce caterpillar or snail herbivory. However, fatty alcohol content was negatively correlated with caterpillar growth, suggesting a role in reducing insect herbivory despite its lower levels. Aphid reproduction and feeding activity were not correlated with wax load and composition but are potentially affected by altered cutin composition of cer1 mutants. When examining non-feeding activities, wax crystal morphology could explain the preference of B. tabaci to lay eggs on wildtype plants relative to cer1 and far mutants. Accordingly, the fatty alcohol wax component reduces caterpillar herbivory on the chemical level, but oviposition is increased when wax crystals are dense. The results suggest that this varied response between herbivore classes and species, at times displaying increased and at times reduced fitness in response to altered wax composition is in part a consequence of co-evolution that shaped the specific effects of different N. glauca metabolites such as anabasine and fatty alcohols in plant-herbivore interactions.
IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay
Authors: Akaki Kotaro , Ogata Kosuke , Yamauchi Yuhei , Iwai Noriki , Tse Ka Man , Hia Fabian , Mochizuki Atsushi , Ishihama Yasushi , Mino Takashi , Takeuchi Osamu 
Published: July 2021

AbstractRegnase-1 is an endoribonuclease crucial for controlling inflammation by degrading mRNAs encoding cytokines and inflammatory mediators in mammals. However, it is unclear how Regnase-1-mediated mRNA decay is controlled in interleukin (IL)-1β or Toll-like receptor (TLR) ligand-stimulated cells. Here, by analyzing the Regnase-1 interactome, we found that IL-1β or TLR stimulus dynamically induced the formation of Regnase-1-β-transducin repeat-containing protein (βTRCP) complex. Importantly, we also uncovered a novel interaction between Regnase-1 and 14-3-3 in both mouse and human cells. Strikingly, both interactions occur in a mutually exclusive manner, underscoring the importance of modulating Regnase-1’s activity. Additionally, we show that in IL-1R/TLR-stimulated cells, the Regnase-1-14-3-3 interaction is mediated by IRAK1 through a previously uncharacterized C-terminal structural domain. Phosphorylation of Regnase-1 at S494 and S513 is critical for Regnase-1-14-3-3 interaction, while a different set of phosphorylation sites of Regnase-1 are known to be required for the recognition by βTRCP and proteasome-mediated degradation. 14-3-3 stabilizes Regnase-1 but abolishes its activity by inhibiting Regnase-1-mRNA association. Furthermore, nuclear-cytoplasmic shuttling of Regnase-1 is abrogated by 14-3-3 interaction. Taken together, the results suggest that a novel inflammation-induced interaction of 14-3-3 with Regnase-1 stabilizes inflammatory mRNAs by sequestering Regnase-1 in the cytoplasm to prevent mRNA recognition.
Reviewing the consequences of genetic purging on the success of rescue programs
Authors: Pérez-Pereira Noelia , Caballero Armando , García-Dorado Aurora 
Published: July 2021

AbstractGenetic rescue is increasingly considered a promising and underused conservation strategy to reduce inbreeding depression and restore genetic diversity in endangered populations, but the empirical evidence supporting its application is limited to a few generations. Here we discuss on the light of theory the role of inbreeding depression arising from partially recessive deleterious mutations and of genetic purging as main determinants of the medium to long-term success of rescue programs. This role depends on two main predictions: (1) The inbreeding load hidden in populations with a long stable demography increases with the effective population size; and (2) After a population shrinks, purging tends to remove its (partially) recessive deleterious alleles, a process that is slower but more efficient for large populations than for small ones. We also carry out computer simulations to investigate the impact of genetic purging on the medium to long term success of genetic rescue programs. For some scenarios, it is found that hybrid vigor followed by purging will lead to sustained successful rescue. However, there may be specific situations where the recipient population is so small that it cannot purge the inbreeding load introduced by migrants, which would lead to increased fitness inbreeding depression and extinction risk in the medium to long term. In such cases, the risk is expected to be higher if migrants came from a large non-purged population with high inbreeding load, particularly after the accumulation of the stochastic effects ascribed to repeated occasional migration events. Therefore, under the specific deleterious recessive mutation model considered, we conclude that additional caution should be taken in rescue programs. Unless the endangered population harbors some distinctive genetic singularity whose conservation is a main concern, restoration by continuous stable gene flow should be considered, whenever feasible, as it reduces the extinction risk compared to repeated occasional migration and can also allow recolonization events.
Inhibitory control performance is repeatable across years and contexts in a wild bird population
Authors: Davidson Gabrielle L. , Reichert Michael S. , Coomes Jennifer R. , Kulahci Ipek G. , de la Hera Iván , Quinn John L. 
Published: July 2021

AbstractInhibitory control is one of several cognitive mechanisms required for self-regulation, decision making and attention towards tasks. Linked to a variety of maladaptive behaviours in humans, inhibitory control is expected to influence behavioural plasticity in animals in the context of foraging, social interaction, or responses to sudden changes in the environment. One widely used cognitive assay, the ‘detour task’, putatively tests inhibitory control. In this task, subjects must avoid impulsively touching transparent barriers positioned in front of food, and instead access the food by an alternative but known route. Recently it has been suggested that the detour task is unreliable and measures factors unrelated to inhibitory control, including motivation, previous experience and persistence. Consequently, there is growing uncertainty as to whether this task leads to erroneous interpretations about animal cognition and its links with socio-ecological traits. To address these outstanding concerns, we designed a variant of the detour task for wild great tits (Parus major) and deployed it at the nesting site of the same individuals across two spring seasons. This approach eliminated the use of food rewards, limited social confounds, and maximised motivation. We compared task performance in the wild with their performance in captivity when tested using the classical cylinder detour task during the non-breeding season. Task performance was temporally and contextually repeatable, and none of the confounds had any significant effect on performance, nor did they drive any of the observed repeatable differences among individuals. These results support the hypothesis that our assays captured intrinsic differences in inhibitory control. Instead of ‘throwing the detour task out with the bathwater’, we suggest confounds are likely system and experimental-design specific, and that assays for this potentially fundamental but largely overlooked source of behavioural plasticity in animal populations, should be validated and refined for each study system.
Diversified physiological sensory input connectivity questions the existence of distinct classes of spinal interneurons
Authors: Kohler Matthias , Bengtsson Fredrik , Stratmann Philipp , Röhrbein Florian , Knoll Alois , Albu-Schäffer Alin , Jörntell Henrik 
Published: July 2021

AbstractThe spinal cord is engaged in all forms of motor performance but its functions are far from understood. Because network connectivity defines function, we explored the connectivity for muscular, tendon and tactile sensory inputs among a wide population of spinal interneurons in the lower cervical segments. Using low noise intracellular whole cell recordings in the decerebrated, nonanesthetized cat in vivo, we could define mono-, di-, trisynaptic inputs as well as the weights of each input. Whereas each neuron had a highly specific input, and each indirect input could moreover be explained by inputs in other recorded neurons, we unexpectedly also found the input connectivity of the spinal interneuron population to form a continuum. Our data hence contrasts with the currently widespread notion of distinct classes of interneurons. We argue that this suggested diversified physiological connectivity, which likely requires a major component of circuitry learning, implies a more flexible functionality.1.Graphical Abstract2.HighlightsIn vivo whole cell, intracellular recording of spinal interneurons.Patterns of input from Ia, Ib and cutaneous afferents is highly diversified.Learning appears to be a defining factor of spinal interneuron connectivity.
Active inference through whiskers
Authors: Mannella Francesco , Maggiore Federico , Baltieri Manuel , Pezzulo Giovanni 
Published: July 2021

AbstractRodents use whisking to probe actively their environment and to locate objects in space, hence providing a paradigmatic biological example of active sensing. Numerous studies show that the control of whisking has anticipatory aspects. For example, rodents target their whisker protraction to the distance at which they expect objects, rather than just reacting fast to contacts with unexpected objects. Here we characterize the anticipatory control of whisking in rodents as an active inference process. In this perspective, the rodent is endowed with a prior belief that it will touch something at the end of the whisker protraction, and it continuously modulates its whisking amplitude to minimize (proprioceptive and somatosensory) prediction errors arising from an unexpected whisker-object contact, or from a lack of an expected contact. We will use the model to qualitatively reproduce key empirical findings about the ways rodents modulate their whisker amplitude during exploration and the scanning of (expected or unexpected) objects. Furthermore, we will discuss how the components of active inference model can in principle map to the neurobiological circuits of rodent whisking.
A novel method for developing post-quantum cryptoschemes and a practical signature algorithm
Authors: Moldovyan Nikolay Andreevich , Moldovyan Dmitriy Nikolaevich 
Published: July 2021

PurposeThe practical purpose of this research is to propose a candidate for post-quantum signature standard that is free of significant drawback of the finalists of the NIST world competition, which consists in the large size of the signature and the public key. The practical purpose is to propose a fundamentally new method for development of algebraic digital signature algorithms.Design/methodology/approachThe proposed method is distinguished by the use of two different finite commutative associative algebras as a single algebraic support of the digital signature scheme and setting two different verification equation for a single signature. A single public key is computed as the first and the second public keys, elements of which are computed exponentiating two different generators of cyclic groups in each of the algebras.FindingsAdditionally, a scalar multiplication by a private integer is performed as final step of calculation of every element of the public key. The same powers and the same scalar values are used to compute the first and the second public keys by the same mathematic formulas. Due to such design, the said generators are kept in secret, providing resistance to quantum attacks. Two new finite commutative associative algebras, multiplicative group of which possesses four-dimensional cyclicity, have been proposed as a suitable algebraic support.Originality/valueThe introduced method is novel and includes new techniques for designing algebraic signature schemes that resist quantum attacks. On its base, a new practical post-quantum signature scheme with relatively small size of signature and public key is developed.
Forecasting Euro against US dollar via combination of NARDL and Univariate techniques during COVID-19
Authors: AsadUllah Muhammad , Bashir Muhammad Adnan , Aleemi Abdur Rahman 
Published: July 2021

Purpose
The purpose of this study is to examine the accuracy of combined models with the individual models in terms of forecasting Euro against US dollar during COVID-19 era. During COVID, the euro shows sharp fluctuation in upward and downward trend; therefore, this study is keen to find out the best-fitted model which forecasts more accurately during the pandemic.

Design/methodology/approach
The descriptive design has been adopted in this research. The three univariate models, i.e. autoregressive integrated moving averages (ARIMA), Naïve, exponential smoothing (ES) model, and one multivariate model, i.e. nonlinear autoregressive distributive lags (NARDL), are selected to forecast the exchange rate of Euro against the US dollar during the COVID. The above models are combined via equal weights and var-cor methods to find out the accuracy of forecasting as Poon and Granger (2003) showed that combined models can forecast better than individual models.

Findings
NARDL outperforms all remaining individual models, i.e. ARIMA, Naïve and ES. By applying a combination of different models via different techniques, the combination of NARDL and Naïve models outperforms all combination of models by scoring the least mean absolute percentage error value, i.e. 1.588. The combined forecasting of NARDL and Naïve techniques under var-cor method also outperforms the forecasting accuracy of individual models other than NARDL. It means the euro exchange rate against the US dollar which is dependent upon the macroeconomic fundamentals and recent observations of the time series.

Practical implications
The findings could help the FOREX market, hedgers, traders, businessmen, policymakers, economists, financial managers, etc., to minimize the risk indulged in global trade. It also helps to produce more accurate results in different financial models, i.e. capital asset pricing model and arbitrage pricing theory, because their findings may not be useful if exchange rate fluctuations do not trace effectively.

Originality/value
The NARDL models have been applied previously in different time series and only limited to the asymmetric or symmetric relationships. This study is using it for the forecasting exchange rate which is almost abandoned in earlier literature. Furthermore, this study combined the NARDL with univariate models to produce the accuracy which itself is a novelty. Moreover, the findings help to enhance the effectiveness of different financial theories as well.
The functions of the National Archives of South Africa regarding universities’ records and archives
Authors: Netshakhuma Nkholedzeni Sidney 
Published: July 2021

Purpose
This paper aims to assess the functions of the National Archives of South Africa regarding universities’ records and archives by comparing the University of the Witwatersrand (Wits) and the University of Venda’s (Univen) implementation of the National Archives and Records Service of South Africa Act, No. 43 of 1996 (NARSSA) provisions 11 and 13, with the view of recommending best practice.

Design/methodology/approach
The quantitative research methodology was adopted. The data collection tool was a questionnaire completed by 34 heads of divisions, departments and units from the Wits and Univen, supplemented by a document review. Thus, the study population comprised universities’ heads of divisions, departments and units.

Findings
The National Archives of South Africa is not playing a role in providing advice to universities on how to manage their records and archives to fulfil their teaching, learning and research mandate, protect them from litigation and preserve their corporate memory such as records with national and international significance. Most of the respondents were not aware of the NARSSA provision 11 on the custody and preservation of records, and provision 13 on the management of public records. NARSSA lacks provision specifically for the management of university records. NARSSA appears vague about the management of university records, as it does not explain the legal definition of university records.

Research limitations/implications
This is a comparative case study limited to Wits and Univen. The shortcoming of this study is that the author did not provide relevant and detailed information for the article reader to fully understand the functions of the NARSSA provisions 11 and 13 regarding university records and archives at Wits and Univen, respectively.

Practical implications
The study recommends the South Africa legislature to review the NARSSA regarding records and archives’ role in the university. The researcher’s view is that reviewing existing NARSSA provisions 11 and 13 would provide universities with the responsibility of managing some of their national and international records. This might improve the management of records and this, in turn, would enhance the preservation of records.

Originality/value
This paper appears to be the first to review the functions of the National Archives of South Africa regarding the South African university’s records and archives.
Evaluation of smart manufacturing performance using a grey theory-based approach: a case study
Authors: Malaga Anilkumar , Vinodh S. 
Published: July 2021

PurposeThe purpose of the article is to report a study on evaluation of smart manufacturing (SM) performance using a grey theory-based approach.Design/methodology/approachIn total, 30 criteria and 79 attributes for SM performance have been developed. A grey theory-based approach has been used for SM performance evaluation. The grey index has been calculated, and weaker areas have been derived. Performance level of SM has been evaluated using the Euclidean distance approach.FindingsThe SM performance index is found to be (3.036, 12.296). The ideal grey performance importance index (GPII) is obtained as (3.025, 4.875). The level of visibility and traceability, vertical integration, lead time and configuration data espionage and control ability are strong performing attributes. Integration abilities of services and manufacturing systems, ability of self-control, worker and raw material productivity, collaboration among buyers and suppliers and dynamic scheduling are identified as weaker areas, and suggestions for improvement have been derived. SM performance level has been identified as “Good.”Research limitations/implicationsAdditional performance measures could be included as a part of evaluation. Practitioners can overcome weaker areas in the early phase. Management achieves confidence and practitioners attain success in implementation of SM in industry through the developed SM performance indexing system.Originality/valueIdentification of SM performance measures and analysis of SM performance is the original contribution of the authors. The developed approach assists practitioners and managers to focus more on specific areas for performance improvement.
How leadership affects organisational citizenship behaviour – a study of independent hotels
Authors: Nazarian Alireza , Atkinson Peter , Foroudi Pantea , Velayati Rezvan , Edirisinghe Dilini , Hosseini Tabaghdehi Asieh 
Published: July 2021

Purpose
The purpose of this paper is to examine the factors that managers in independent hotels can influence to improve organisational citizenship behaviour (OCB) by examining the relationship between leadership style and OCB through newly developed balanced organisational culture and trust variables. Unlike most studies, which have been on chain hotels, this study investigates these relationships in independent hotels in Iran. Additionally, organisational size was also included in the study.

Design/methodology/approach
Using information from Ministry of Cultural Heritage, Handicrafts and Tourism, 160 independent hotels were identified and approached. A survey was assembled using well-known instruments. In total, 392 usable questionnaires out of 1,150 distributed were collected from employees and analysed using structural equation modelling.

Findings
Contrary to previous studies, it was found that in this context, neither transformational nor transactional leadership affects trust directly but only through balanced organisational culture, and only transactional leadership had a direct relationship with OCB. Also, organisational size had a moderating effect on the relationship between trust and OCB.

Originality/value
The authors add to the theoretical literature dealing with the different behaviour of constructs developed in a Western context in other contexts and suggests that hotel managers in a collectivist culture, like Iran, who want to build OCB can do so by creating organisational culture conditions (Balanced Organisational Culture) that foster trust between managers and their subordinates.