bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statistical analysis of ionospheric total electron content (TEC): Long-term estimation of extreme TEC in Japan
Authors: Nishioka Michi , Saito Susumu , Tao Chihiro , Shiota Daikou , Tsugawa Takuya , Ishii Mamoru 
Published: January 2021

Abstract
Ionospheric total electron content (TEC) is one of the key parameters for users of radio-based systems, such as the Global Navigation Satellite System, high-frequency communication systems, and space-based remote sensing systems, since total ionospheric delay is proportional to TEC through the propagation path. It is important to know extreme TEC values in readiness for hazardous ionospheric conditions. The purpose of this study is to estimate extreme TEC values with occurrences of once per year, ten years, and hundred years in Japan. In order to estimate the extreme values of TEC, a cumulative distribution function of daily TEC is derived using 22 years of TEC data from 1997 to 2018. The extreme values corresponding to once per year and ten years are 90 and 110 TECU, respectively, in Tokyo, Japan. On the other hand, the 22-year data set is not sufficient to estimate the once-per-hundred-year value. Thus, we use the 62-year data set of manually scaled ionosonde data for the critical frequency of the F-layer (foF2) at Kokubunji in Tokyo. First, we study the relationship between TEC and foF2 for 22 years and investigate the slab thickness. Then the result is applied to the statistical distribution of foF2 data for 62 years. In this study, two methods are applied to estimate the extreme TEC value. In the first method, the distribution of slab thickness is artificially inflated to estimate extreme TEC values. In the second method, extreme slab thicknesses are applied to estimate extreme TEC values. The result shows that the once-per-hundred-year TEC is about 150-190 TECU at Tokyo. The value is also estimated to be 180-230 TECU in Kagoshima and 120-150 TECU in Hokkaido, in the southern and northern parts of Japan, respectively.
Lymphatic muscle cells contribute to dysfunction of the synovial lymphatic system in inflammatory arthritis in mice
Authors: Liang Qianqian , Zhang Li , Xu Hao , Li Jinlong , Chen Yan , Schwarz Edward M. , Shi Qi , Wang Yongjun , Xing Lianping 
Published: January 2021

Abstract
Background. Our previous studies reveal that impaired draining function of the synovial lymphatic vessel (LV) contributes to the pathogenesis of inflammatory arthritis, but the cellular and molecular mechanisms involved are not fully understood. Objective. To investigate the involvement of lymphatic muscle cells (LMCs) in mediating impaired LV function in inflammatory arthritis. Methods. TNF transgenic (TNF-Tg) arthritic mice were used. Structure and function of the LVs that drained the hind limbs were examined by whole-mount immunofluorescence staining, electron microscopy, and near-infrared lymphatic imaging. Primary LMCs were treated with TNF, and the changes in proliferation, apoptosis, and functional gene expression were assessed. The roles of the herbal drug, Panax Notoginseng Saponins (PNS), in arthritis and LVs were studied.Results. TNF-Tg mice developed ankle arthritis with age, which was associated with abnormalities of LVs: 1) dilated capillary LVs with few branch points; 2) mature LVs with reduced LMC coverage and draining function; 3) degenerative and apoptotic appearance of LMCs. TNF caused LMC apoptosis, reduced expression of muscle functional genes, and promoted the production of nitric oxide (NO) by lymphatic endothelial cells (LECs). PNS attenuated arthritis, restored LMC coverage and draining function of mature LVs, inhibited TNF-mediated NO expression, and reduced LMC apoptosis. Conclusion. The impaired draining function of LVs in TNF-Tg mice involves LMC apoptosis. TNF promotes LMC death directly and indirectly via NO production by LECs. PNS attenuates arthritis, improves LVs, and prevents TNF-induced LMC apoptosis by inhibiting NO production of LECs. LMCs contribute to the dysfunction of synovial LVs in inflammatory arthritis.
Psychiatric morbidity in children and adolescents with dermatological disorders
Authors: Miniksar Dilşad Yıldız , Özcan Özlem Özel , Cenk Hülya , Kapıcıoğlu Yelda , Polat Ayşegül 
Published: January 2021

Abstract

Background:
Understanding the existence of a cycle, where psychological disturbances cause skin diseases and in turn, skin diseases cause psychological disorders, provides the basis for good dermatological practice.

Objective:
The aim of this case-control study is to examine the psychiatric morbidity of dermatological disorders in children and adolescents with no history of psychiatric disorders.

Method:
In this study, 502 participants (251 patients and 251 healthy individuals) were evaluated according to DSM-IV criteria. All participants were interviewed and evaluated using the Turkish version of the Kiddie Schedule for Affective Disorders and Schizophrenia – Present and Lifetime Version (K-SADS-PL) and the State-Trait Anxiety Inventory for Children (STAI-1 and STAI-2), the Childhood Depression Inventory (CDI), adolescent and parent forms of the Strengths and Difficulties Questionnaire (SDQ-A and SDQ-P) and a questionnaire evaluating child’s level of school success.

Results:
Our results indicated that the rates of general psychiatric comorbidity, mood disorders, anxiety disorders, and adjustment disorders were significantly higher in the study group compared to the control group. The CDI, STAI-1, STAI-2, and SDQ (and subscales) scores were significantly higher in the study group. Moreover, psychiatric comorbidity was higher in inflammatory and allergic dermatoses compared to other dermatological subgroups. Having a dermatological disease restricts physical activity thus increasing the risk of psychiatric comorbidity.

Conclusions:
Investigating the education, attitudes, and awareness of dermatologists about psychocutaneous disorders might contribute to the development of new educational strategies and elicit appropriate biopsychosocial approaches.
Peculiarities of free economic zones formatiob in countries with transition economies
Authors: Алексахина В.Г. , Игнатова О.В. 
Published: January 2021

В статье рассматриваются аспекты эволюции свободных экономических зон, и выделяются критерии отнесения территории к СЭЗ. Анализируются причины популярности использования СЭЗ в качестве инструмента инвестиционной политики, а также особенности формирования СЭЗ в странах с переходной экономикой, включая Россию.
The article deals with aspects of free economic zones evolution, and highlights the criteria for classifying a territory as a free economic zone. The reasons for the popularity of free economic zones use as an instrument of investment policy are analyzed, as well as the features of free economic zones formation in countries with transition economies, including Russia.
On the issue of financial mechanism calculation of the pensioner 's living wage in the context of realizing the right to a decent old age
Authors: Серяева М.Г. , Шкуропатова Ю.А. 
Published: January 2021

Прожиточный минимум пенсионера является важным социальным и экономическим показателем, используемым для расчета минимальной пенсии в России, для разработки мер социальной поддержки пенсионеров и социальных программ, оценки уровня пенсионного обеспечения в стране. Важной проблемой в настоящее время является недостаточная обоснованность факторов, принимаемых во внимание при расчете величины прожиточного минимума пенсионера. В статье изложены рекомендации о необходимости учета дополнительных расходов пенсионеров, продиктованные необходимостью обеспечить реализацию их права на достойную старость.
The pensioner's subsistence minimum is an important social and economic indicator used to calculate the minimum pension in Russia, to develop social support measures for pensioners and social programs, and to assess the level of pension provision in the country. An important problem at present is the lack of validity of factors taken into account when calculating the cost of living of a pensioner. The article provides recommendations on the need to take into account the additional expenses of pensioners, dictated by the need to ensure the realization of their right to a decent old age.
Regional Human Resources Replenishment Analysis: expectations, factors, reality
Authors: Бакушева Г.В. 
Published: January 2021

В статье исследуется ожидаемое и фактическое пополнение человеческих ресурсов в субъектах Российской Федерации, выявляются регионы - центры притяжения человеческих ресурсов. Выполняется группировка регионов по основным факторам межрегиональной миграции с помощью иерархической процедуры кластерного анализа. Делается вывод о необходимости учета кластерных различий при формировании стратегии пространственного развития.
The article considers the expected and actual human resources replenishment in the subjects of the Russian Federation; regions that are the centers of human resources attraction are identified. The hierarchical clustering is used to group the regions by the main factors of interregional migration. It is concluded that the cluster differences must be taken into account when defining the spatial development strategy.
System of indicators of social threats to economic security of the state
Authors: Агапова Т.Н. , Рукавишникова Е.С. 
Published: January 2021

Сформирована система показателей социальных угроз для оценки экономической безопасности личности и государства. Проведен анализ динамики данных показателей России за период с 2000 года по 2018 год и выявлен ряд критических значений. Сделан вывод о необходимости создания системы оценки и диагностики социальных показателей.
A system of indicators of social threats has been Formed to assess the economic security of individuals and the state. The analysis of the dynamics of these indicators in Russia for the period from 2000 to 2018 and identified a number of critical values. It is concluded that it is necessary to create a system for evaluating and diagnosing social indicators.
The evaluation of strategic advantages influence on the competitiveness of a company
Authors: Медведева Н.А. , Родионова Т.Г. 
Published: January 2021

В исследовании рассматриваются методические аспекты выбора стратегии конкурентных преимуществ на примере компаний целлюлозно-бумажной отрасли. Разработанная система показателей позволяет определиться с выбором стратегии, обеспечивающей стабильное развитие компаний, а обоснованный алгоритм принятия решений о стратегических приоритетах позволяет учитывать мнения всех заинтересованных сторон.
In the study the methodical aspects of choosing the strategy of competitive advantages are considered through the example of the companies of the pulp and paper sector. The developed system of indexes allows deciding for a strategy which ensures the sustainable development of companies, and a proved decision-making algorithm of strategic priorities allows taking into account the opinions of all concerned parties.
Computing devices of cloud-based control systems and their status monitoring
Authors: Аббасова Т.С. 
Published: January 2021

Проанализированы типовые устройства вычислительной техники для реализации облачных систем управления на основе оборудования центров обработки данных. Поставлена задача сформулировать виды контроля исследуемых устройств; найти расчетные соотношения для определения показателей, характеризующих виды контроля; а также определить средства технического мониторинга, контролирующие облачные системы управления. Проанализированы характеристики широко применяющегося в облачных системах управления сервиса резервного копирования и восстановления данных. Разработаны оценки для контроля параметров облачных систем управления.
Typical computing devices for implementing cloud-based control systems based on data center equipment are analyzed. The task is to formulate the types of control of the studied devices; find the calculated ratio to determine indicators characterizing the types of control; and identify technical monitoring tools that control cloud-based management systems. The characteristics of the backup and data recovery service widely used in cloud management systems are analyzed. Estimates have been developed to control the parameters of cloud-based management systems.
Information system interoperability support of regional situational centers: problems and technologies
Authors: Маслобоев А.В. 
Published: January 2021

В работе рассматриваются цели и проблематика обеспечения интероперабельности информационно-управляющих систем региональных ситуационных центров. Выделены три типа проблем поддержки интероперабельности на технологическом, семантическом и организационном уровнях взаимодействия компонентов этих систем. Предлагаются пути решения задач обеспечения интероперабельности информационных систем ситуационных центров региона, основанные на применении агентных технологий и онтологий и обеспечивающие интеграцию распределенных компонентов в единую сетецентрическую среду и совместное использование информационных ресурсов.
The paper considers goals and problems of information-management system interoperability support of the regional situational centers. Three types of the information system components interoperability support problem at technological, semantic and organizational interaction level are assigned. Problem-solving directions of information system interoperability support of regional situational centers based on application of multi-agent technologies and ontologies are proposed. That provides system component integration in the unified network-centric environment and information resources sharing.
Application of neural network expert systems for monitoring, diagnostics and forecasting of technical condition of aircraft engines
Authors: Пушкарёв Д.О. 
Published: January 2021

Рассматривается применение нейросетевых экспертных систем в области контроля, диагностики и прогнозирования технического состояния авиационных ГТД на основе нечеткой логики. Показана методика для решения таких задач в области технической эксплуатации авиационной техники совместно с использованием фаззи-интерференсной системы программы MATLAB. Используя статистические данные о работе двигателя формируется экспертная система на основе нейронной сети позволяющая осуществлять контроль и диагностику ГТД, а также прогнозировать дальнейшее техническое состояния анализируемого двигателя.
The application of neural network expert systems in the field of monitoring, diagnostics and forecasting of the technical condition of aviation gas turbine engines based on fuzzy logic is considered. The technique for solving such problems in the field of technical operation of aircraft and using the fuzzy-interference system of the MATLAB program is shown. Using statistical data on the operation of the engine, an expert system is based on the fundamental of a neural network that provide monitoring and diagnostics of gas turbine engines, as well as predicting the further technical condition of the analyzed engine.
Optimization of the parameters of advanced multi-beam satellite systems
Authors: Теодорович Н.Н. , Ковалев И.И. , Семенов А.Б. 
Published: January 2021

Исследовано техническое обеспечение спутниковых многолучевых систем прямого направления и поставлена задача оптимизации параметров этих систем. На основе анализа параметров космического сегмента для абонентских лучей и структуры передающей части бортового ретранслятора предложены варианты частотно-поляризационного плана для улучшения энергетического потенциала спутниковой системы. Показаны способы увеличения зоны обслуживания луча исследуемых систем более чем в 2 раза.
The technical support of satellite multi-beam systems of the forward direction is investigated and the problem of optimization of the parameters of these systems is set. Based on the analysis of the parameters of the space segment for subscriber beams and the structure of the transmitting part of the on-board repeater, variants of the frequency-polarization plan are proposed to improve the energy potential of the satellite system. Methods of increasing the service area of the beam of the systems under study by more than 2 times are shown.
Perfil dos enfermeiros perfusionistas brasileiros atuantes no mercado de trabalho
Authors: Nicoletti Andrelise Maria 
Published: January 2021

Objetivo: traçar o perfil dos enfermeiros perfusionistas brasileiros atuantes no mercado de trabalho. Métodos: trata-se de um estudo observacional com delineamento transversal. Foram obtidos dados de perfil sócio demográfico e profissional dos perfusionistas em situação ativa no Brasil através do preenchimento de um questionário eletrônico. A amostra contemplou 70 enfermeiros perfusionistas. Resultados: a maioria dos profissionais é do sexo feminino (44%), possui 38,3±8,62 anos. A formação complementar demonstra um período de transição e aperfeiçoamento nesta especialidade: 84,2% destes possuem pós-graduação. Conclusão: o perfil profissional dos enfermeiros perfusionistas está em franca evolução em termos de qualificação e, nesse enfoque, torna-se necessário o conhecimento da especialidade para o delineamento de novas ações e inserção profissional em diferentes cenários da tecnologia extracorpórea.Descritores: Circulação Extracorpórea; Procedimentos Cirúrgicos Cardiovasculares; Enfermagem. Objective: to profile the Brazilian perfusionist nurses working in the labor market. Methods: This is an observational study with cross-sectional design. Data on socio-demographic and professional profile of perfusionists in active situation in Brazil were obtained by completing an electronic questionnaire. The sample included 70 perfusionist nurses. Results: most professionals are female (44%), 38.3 ± 8.62 years old. Complementary education demonstrates a period of transition and improvement in this specialty: 84.2% of these have postgraduate degrees. Conclusion: the professional profile of perfusionist nurses is clearly evolving in terms of qualification and, in this approach, it is necessary to know the specialty to delineate new actions and professional insertion in different scenarios of extracorporeal technology.Keywords: Cardiopulmonary bypass; Cardiovascular Surgical Procedures; Nursing. Objetivo: perfilar las enfermeras perfusionistas brasileñas que trabajan en el mercado laboral. Métodos: Este es un estudio observacional con diseño transversal. Los datos sobre el perfil sociodemográfico y profesional de perfusionistas en situación activa en Brasil se obtuvieron completando un cuestionario electrónico. La muestra incluyó 70 enfermeras perfusionistas. Resultados: la mayoría de los profesionales son mujeres (44%), 38.3 ± 8.62 años. La educación complementaria demuestra un período de transición y mejora en esta especialidad: 84,2% de ellos tienen títulos de posgrado. Conclusión: el perfil profesional de las enfermeras perfusionistas está evolucionando claramente en términos de calificación y, en este enfoque, es necesario conocer la especialidad para delinear nuevas acciones e inserción profesional en diferentes escenarios de tecnología extracorpórea.Descriptores: Circulacion Extracorporea; Procedimientos quirúrgicos cardiovasculares; Enfermería.
Association Between Total Bilirubin Levels and Cardio-Metabolic Risk
Factors Related to Obesity
Authors: El-Eshmawy Mervat M. , Mahsoub Nancy , Asar Mohamed , Elsehely Ibrahim 
Published: January 2021

Background:
The link between bilirubin and cardiometabolic outcomes has been previously
identified with positive health effects of mild hyperbilirubinaemia. On the other hand, recent
evidence has suggested an association between low circulating bilirubin levels and obesity. This
study was conducted to assess the association of total bilirubin levels with metabolic and cardiovascular
risk factors related to obesity.

Methods:
A total of 50 obese adults and 50 healthy controls matched for age and sex were enrolled
in this study. Anthropometric measurements, fasting glucose, fasting insulin, homeostasis model assessment
of insulin resistance (HOMA-IR), HOMA- β (%), lipids profile, monocyte to lymphocyte
ratio (MLR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), uric acid,
gamma glutamyl transpeptidase (GGT), AST/ALT ratio and total bilirubin were assessed.

Results:
Total bilirubin, high density lipoprotein cholesterol (HDL-C) and AST/ALT ratio were significantly
lower, whereas fasting insulin, HOMA-IR, total cholesterol, triglycerides, low density
lipoprotein cholesterol, NLR, uric acid and GGT were significantly higher in obese adults than in
healthy controls. Bilirubin was negatively associated with body mass index, waist circumference,
fasting insulin, HOMA-IR, NLR, PLR, uric acid, and positively associated with HDL-C. HDL-C
and NLR were the independent predictor variables of total bilirubin.

Conclusion:
Among all the studied cardio-metabolic risk factors, HDL-C and NRL are the most
closely associated variables with total bilirubin levels in obese adults.
Automated Radiosynthesis and Molecular Docking Studies of Coumarin- Triazole Hybrid with fluorine-18: A feasibility study
Authors: Goud Nerella Sridhar , Kumar Pardeep , Ghouse Mahammad S. , Nagaraju Chandana , Bharath Rose Dawn , Alvala Mallika 
Published: January 2021

Background:Fluorine-18 is one of the promising radiotracers that can report target specific information related to its physiology to understand the disease status through PET modality. In current study, the radiochemical synthesis, purification and molecular docking studies of fluorine-18 (18F) radiolabeled coumarin-triazole hybrid have been performed.Objective:To develop target specific fluorine-18 radiotracer for the diagnosis in oncology.Methods:GE Tracer-lab FX2N module with few modifications in the line connections was used for the radiosynthesis and purification of target molecule [18F]SG-2, 4-((2,6-dimethylmorpholino) methyl)-7-((1-(4-(fluoro-18F) benzyl)-1H-1,2,3-triazol-4-yl) oxy)-2H-chromen-2-one, through the nucleophilic radiofluorination mechanism. The radiochemical purity was measured by HPLC, and TLC analytical methods. The kryptofix levels were also evaluated by using TLC method. The residual solvents like DMF, ethanol was measured using GC. The Schrödinger drug discovery suite 2018 was used to study the protein and ligand interactions.Results:The quality control parameters revealed the purity, chemical identity, and limits of residual solvents. The radiochemical purity was 95.5 ± 2.3 %, and dimethyl formamide solvent limit was 89  3 ppm. The molecular docking results had suggested that the cold target molecule has made strong electronic interactions and showed the possible pharmacokinetic (ADME) properties with galectin-1 protein. Overall, these results showed that [18F]SG-2 radiolabeling with 18F radionuclide was feasible, and support of molecular docking studies suggest possible interactions with Galectin-1.Conclusion:we reported feasibility study for labeling coumarin-triazole hybrid with fluorine-18 through aromatic nucleophilic fluorination reaction (SNAr).