bluuebunny/crossref_metadata_2025_split huggingface dataset:
Split Questionnaire Designs for Online Surveys: The Impact of Module Construction on Imputation Quality
Authors: Axenfeld Julian B , Blom Annelies G , Bruch Christian , Wolf Christof 
Published: December 2021

AbstractEstablished face-to-face surveys encounter increasing pressures to move online. Such a mode switch is accompanied with methodological challenges, including the need to shorten the questionnaire that each respondent receives. Split Questionnaire Designs (SQDs) randomly assign respondents to different fractions of the full questionnaire (modules) and, subsequently, impute the data that are missing by design. Thereby, SQDs reduce the questionnaire length for each respondent. Although some researchers have studied the theoretical implications of SQDs, we still know little about their performance with real data, especially regarding potential approaches to constructing questionnaire modules. In a Monte Carlo study with real survey data, we simulate SQDs in three module-building approaches: random, same topic, and diverse topics. We find that SQDs introduce bias and variability in univariate and especially in bivariate distributions, particularly when modules are constructed with items of the same topic. However, single topic modules yield better estimates for correlations between variables of the same topic.
Unequal-mass mergers of dark matter haloes with rare and frequent self-interactions
Authors: Fischer Moritz S , Brüggen Marcus , Schmidt-Hoberg Kai , Dolag Klaus , Ragagnin Antonio , Robertson Andrew 
Published: December 2021

ABSTRACT
Dark matter (DM) self-interactions have been proposed to solve problems on small length scales within the standard cold DM cosmology. Here, we investigate the effects of DM self-interactions in merging systems of galaxies and galaxy clusters with equal and unequal mass ratios. We perform N-body DM-only simulations of idealized setups to study the effects of DM self-interactions that are elastic and velocity-independent. We go beyond the commonly adopted assumption of large-angle (rare) DM scatterings, paying attention to the impact of small-angle (frequent) scatterings on astrophysical observables and related quantities. Specifically, we focus on DM-galaxy offsets, galaxy–galaxy distances, halo shapes, morphology, and the phase–space distribution. Moreover, we compare two methods to identify peaks: one based on the gravitational potential and one based on isodensity contours. We find that the results are sensitive to the peak finding method, which poses a challenge for the analysis of merging systems in simulations and observations, especially for minor mergers. Large DM-galaxy offsets can occur in minor mergers, especially with frequent self-interactions. The subhalo tends to dissolve quickly for these cases. While clusters in late merger phases lead to potentially large differences between rare and frequent scatterings, we believe that these differences are non-trivial to extract from observations. We therefore study the galaxy/star populations which remain distinct even after the DM haloes have coalesced. We find that these collisionless tracers behave differently for rare and frequent scatterings, potentially giving a handle to learn about the micro-physics of DM.
Using a chemical genetic screen to enhance our understanding of the antimicrobial properties of copper
Authors: Gugala Natalie , Salazar-Alemán Daniel A , Chua Gordon , Turner Raymond J 
Published: December 2021

Abstract
The competitive toxic and stress-inducing nature of copper necessitates systems that sequester and export this metal from the cytoplasm of bacterial cells. Several predicted mechanisms of toxicity include the production of reactive oxygen species, thiol depletion, DNA, and iron–sulfur cluster disruption. Accompanying these mechanisms include pathways of homeostasis such as chelation, oxidation, and transport. Still, the mechanisms of copper resistance and sensitivity are not fully understood. Furthermore, studies fail to recognize that the response to copper is likely a result of numerous mechanisms, as in the case for homeostasis, in which proteins and enzymes work as a collective to maintain appropriate copper concentrations. In this study, we used the Keio collection, an array of 3985 Escherichia coli mutants, each with a deleted non-essential gene, to gain a better understanding of the effects of prolonged exposure to copper. In short, we recovered two copper homeostatic genes involved in transporting and assembling that are required in mediating prolonged copper stress under the conditions assessed. The gene coding for the protein TolC was uncovered as a sensitive hit, and we demonstrated that tolC, an outer membrane efflux channel, is key in mitigating copper sensitivity. Additionally, the activity of tRNA processing was enriched along with the deletion of several proteins involved in importing generated copper tolerance. Lastly, key genes belonging to central carbon metabolism and nicotinamide adenine dinucleotide biosynthesis were uncovered as tolerant hits. Overall, this study shows that copper sensitivity and tolerance are a result of numerous mechanisms acting in combination within the cell.
Fiduciary Duties, Secret Profits, and the Illegality Defence: Crown Prosecution Service v Aquila Advisory Ltd [2021] UKSC 49
Authors: Purewal Anita 
Published: December 2021

Abstract
CPS v Aquila Advisory Ltd has provided a welcomed judgment on the application of the illegality defence in the context of secret profits accrued in breach of fiduciary duties. The judgment clarifies the priority to be given to constructive trusts over unauthorised fiduciary profits in the face of CPS confiscation orders, and examines the interrelationship between the rules of attribution and the application of the illegality defence today, namely whether a director’s unlawful intention can be attributed to their company to prevent the company, on illegality grounds, from exercising a proprietary interest over the secret profits accrued.
Effects of elevated CO2 concentration and nitrogen addition on the chemical compositions, construction cost and payback time of subtropical trees in Cd-contaminated mesocosm soil
Authors: Zang Xiaowei , Luo Xianzhen , Hou Enqing , Zhang Guihua , Zhang Xiaofeng , Xiao Meijuan , Wen Dazhi , Zhang Lingling 
Published: December 2021

AbstractRising atmospheric CO2 concentration ([CO2]) and nitrogen (N) deposition are changing plant growth, physiological characteristics and chemical compositions; however, few studies have explored such impacts in a heavy metal-contaminated environment. In this study, we conducted an open-top chamber experiment to explore the impacts of 2 years of elevated atmospheric [CO2] and N addition on the growth, physiological characteristics and chemical compositions of five subtropical tree species in a cadmium (Cd)-contaminated environment. Results showed that N addition significantly increased concentration of leaf N and protein in five tree species and also decreased payback time (PBT) and leaf carbon:nitrogen ratios and increased tree relative height growth rate (RGR-H) and basal diameter growth rate (RGR-B) in Liquidambar formosana Hance and Syzygium hainanense Chang et Miau. Elevated [CO2] increased leaf maximum photosynthetic rate (Amax) and concentration of total non-structural carbohydrates and shortened PBT to offset the negative effect of Cd contamination on RGR-B in Acacia auriculiformis A. Cunn. ex Benth. The combined effects of elevated [CO2] and N addition did not exceed their separate effects on RGR-H and RGR-B in Castanopsis hystrix Hook. f. & Thomson ex A. DC. and Cinnamomum camphora (L.) presl. The addition of N significantly increased the concentration of leaf Cd by 162.1% and 338.0%, and plant Cd bio-concentration factor by 464% and 861% in C. hystrix and C. camphora, respectively, compared with only Cd addition. Among the five tree species, the decrease in PBT and the increase in Amax, RGR-B and concentrations of leaf protein in response to N and Cd addition under elevated [CO2] were on average 86.7% higher in A. auriculiformis than other species, suggesting that the mitigation of the negative effects of Cd pollution by elevated [CO2] and N addition among five species was species-specific. Overall, we concluded that N addition and elevated [CO2] reduced Cd toxicity and increased the growth rate in A. auriculiformis, S. hainanense and L. formosana, while it maintained the growth rate in C. hystrix and C. camphora by differently increasing photosynthetic rate, altering the leaf chemical compositions and shortening PBT.
Altered Heart Rate Variability Early in ICU Admission Differentiates Critically Ill Coronavirus Disease 2019 and All-Cause Sepsis Patients
Authors: Kamaleswaran Rishikesan , Sadan Ofer , Kandiah Prem , Li Qiao , Coopersmith Craig M. , Buchman Timothy G. 
Published: December 2021

IMPORTANCE:
Altered heart rate variability has been associated with autonomic dysfunction in a number of disease profiles, in this work we elucidate differences in the biomarker among patients with all-cause sepsis and coronavirus disease 2019.

OBJECTIVES:
To measure heart rate variability metrics in critically ill coronavirus disease 2019 patients with comparison to all-cause critically ill sepsis patients.

DESIGN, SETTING, AND PARTICIPANTS:
Retrospective analysis of coronavirus disease 2019 patients admitted to an ICU for at least 24 hours at any of Emory Healthcare ICUs between March 2020 and April 2020 up to 5 days of ICU stay. The comparison group was a cohort of all-cause sepsis patients prior to coronavirus disease 2019 pandemic.

MAIN OUTCOMES AND MEASURES:
Continuous waveforms were captured from the patient monitor. The electrocardiogram was then analyzed for each patient over a 300 seconds observational window that was shifted by 30 seconds in each iteration from admission till discharge. A total of 23 heart rate variability metrics were extracted in each iteration. We use the Kruskal-Wallis and Steel-Dwass tests (p < 0.05) for statistical analysis and interpretations of heart rate variability multiple measures.

RESULTS:
A total of 141 critically ill coronavirus disease 2019 patients met inclusion criteria, who were compared with 208 patients with all-cause sepsis. Three nonlinear markers, including the ratio of standard deviation derived from the Poincaré plot, sample entropy, and approximate entropy and four linear features, including mode of beat-to-beat interval, acceleration capacity, deceleration capacity, and the proportion of consecutive RR intervals that differ by more than 50 ms, were all statistically significant (p < 0.05) between the coronavirus disease 2019 and all-cause sepsis cohorts. The three nonlinear features and acceleration capacity, deceleration capacity, and beat-to-beat interval (mode) were statistically significant (p < 0.05) when comparing pairwise analysis among the combinations of survivors and nonsurvivors between the coronavirus disease 2019 and sepsis cohorts. Temporal analysis of the main markers showed low variability across the 5 days of analysis compared with sepsis patients.

CONCLUSIONS AND RELEVANCE:
In this descriptive statistical study, heart rate variability measures were found to be statistically different across critically ill patients infected with severe acute respiratory syndrome coronavirus 2 and distinct from bacterial sepsis.
A Tale of Two Waves: Changes in the Use of Noninvasive Ventilation and Prone Positioning in Critical Care Management of Coronavirus Disease 2019
Authors: Parker Alexander J. , Mishra Monalisa , Tiwary Pooja , Sharman Mike , Priya-Sharma Manu , Duncan Alastair , Shanmugam Mohan , Bhatia Kailash , Fullwood Catherine , Martin Andrew D. , Wilson Anthony 
Published: December 2021

Importance:
New treatments and increased experience are changing the management of hospitalized coronavirus disease 2019 patients but the impact on ICU management is unclear.

Objectives:
To examine characteristics, ventilatory management, and outcomes of critically ill patients in two distinct waves of the pandemic.

Design, Setting, and Participants:
Observational cohort study in an ICU in a single-center university-affiliated U.K. hospital. Two-hundred ten adults with coronavirus disease 2019 admitted to ICU between March 17, 2020, to May 31, 2020, and September 1, 2020, to December 10, 2020, with hourly data and 100% follow-up to ICU discharge.

Main Outcomes and Measures:
Data were extracted from the electronic medical record for patient characteristics and clinical data. Patients were classified into distinct waves of the pandemic and assessed for differences between the two waves.

Results:
The duration of noninvasive ventilation/nasal high flow increased in wave 2 versus wave 1, both in self-ventilating patients (107 vs 72 hr; p = 0.02), and in those ultimately requiring invasive mechanical ventilation (34 vs 10 hr; p = 0.02). The proportion of survivors treated without invasive mechanical ventilation increased in wave 2 (59% vs 39%; p = 0.01). In both waves, longer duration of noninvasive ventilation/nasal high flow prior to intubation was associated with higher ICU mortality (survivors 10 hr [4–21 hr] vs nonsurvivors 50 hr [23–124 hr]; p < 0.01). Proned invasive mechanical ventilation was common (54.7%) and prolonged. In wave 2, invasive mechanical ventilation patients were generally more hypoxic with proning initiated at lower Pao2/Fio2 ratios (81 vs 116 mm Hg; p = 0.02) and yielding smaller improvements in Fio2 requirements. Continued proning episodes despite poor responses were commonplace and typically futile. Length of stay for patients requiring tracheostomy increased markedly in wave 2 (51.3 vs 33.7 d; p = 0.03). Overall survival remained similar in wave 2 (68.0% vs 60.9%; p = 0.31).

Conclusions and Relevance:
Our data suggest that management of critically ill coronavirus disease 2019 patients is changing with more survivors avoiding invasive mechanical ventilation. Duration of noninvasive ventilation/nasal high flow use is increasing, which may be associated with worsening outcomes for individuals who require invasive mechanical ventilation. Among invasively ventilated patients, changes in the use of and response to prone positioning and increased length of stay following tracheostomy may imply that the care of these patients is becoming more challenging.
Definitive Chemoradiotherapy Results in Synchronous Oligometastatic Non–small Cell Lung Cancer Patients
Authors: Duru Birgi Sumerya , Akgun Zuleyha , Hurmuz Pervin , Akyurek Serap , Kaytan Saglam Esra , Yilmaz Melek Tugce , Bakirarar Batuhan , Cengiz Mustafa 
Published: December 2021

Objective:
It is aimed to investigate the survival outcomes and prognostic factors after curative treatment of patients diagnosed with synchronous oligometastatic non–small cell lung carcinoma.

Materials and Methods:
Fifty-two patients from 3 centers diagnosed between 2014 and 2019 were analyzed. The treatment results of thoracic and oligometastatic regions were retrospectively evaluated. The Kaplan-Meier method was used to determine the overall survival (OS) and progression-free survival (PFS) and log-rank tests for the factors affecting survival. Cox regression analysis was employed for multivariate analysis.

Results:
Of the 52 patients, 46 (88%) had <2 organ involvement at diagnosis. Treatment of oligometastasis was radiotherapy (RT) in 37, surgery in 4, and surgery with RT in 11 patients. Median 60 Gy were administered to the thoracic tumor. Median RT dose for oligometastasis was 30 Gy in median 5 fractions with either stereotactic body radiation therapy or conventional RT. The median follow-up was 18 months. The median OS and PFS were 35 and 20 months, respectively. The 1-, 2-, and 3-year OS rates were 80.5%, 60.2%, and 41.2%, while the corresponding PFS rates were 75%, 42.5%, and 21.5%, respectively. Multivariate Cox regression analysis revealed that the Eastern Cooperative Oncology Group performance status of “0” and thoracic RT dose over 60 Gy were significant prognostic factors for both the OS and PFS.

Conclusions:
Definitive chemoradiotherapy to the thoracic tumor and treatment of oligometastasis region indicate promising survival outcomes.
Comparison of Long-Term Effectiveness and Safety of Microwave and Surgery in the Treatment of Axillary Osmidrosis: A Single-Center Retrospective Study
Authors: Chen Si-Qi , Wang Ting-Ting , Zhou Yuan , Li Wei , Man Xiao-Yong 
Published: December 2021

BACKGROUND
A microwave-based device is a newly developed method for treating axillary osmidrosis. Few studies have compared the difference between microwave therapy and subcutaneous curettage for axillary osmidrosis.

OBJECTIVE
To compare the long-term effectiveness, complications, and recurrence of osmidrosis after microwave therapy and subcutaneous curettage.

METHODS AND MATERIALS
Medical records of 155 patients with osmidrosis treated with microwave therapy or subcutaneous curettage were reviewed retrospectively. Demographic data, visual analog scale for odor, hyperhidrosis disease scale, complications, and recurrence were analyzed.

RESULTS
Osmidrosis improved significantly in both treatment groups at 6 months. Effective improvement was observed in 90% and 23% of the patients in the surgery and microwave groups, respectively, after 3 years postoperatively. The recurrence rates were 39% and 21% in the microwave and surgery groups, respectively. The transient complication rate was higher in the microwave group, and long-term complications only occurred in the surgery group.

CONCLUSION
Subcutaneous curettage is a more effective approach for axillary osmidrosis. However, microwave therapy is recommended for patients with cosmetic concerns.
The Joint Effects of Depression and Comorbid Psychiatric Disorders on Suicide Deaths
Authors: Jiang Tammy , Nagy Dávid , Rosellini Anthony J. , Horváth-Puhó Erzsébet , Keyes Katherine M. , Lash Timothy L. , Galea Sandro , Sørensen Henrik T. , Gradus Jaimie L. 
Published: December 2021

Background:
Previous studies of the effect of interaction between psychiatric disorders on suicide have reported mixed results. We investigated the joint effect of depression and various comorbid psychiatric disorders on suicide.

Methods:
We conducted a population-based case–cohort study with all suicide deaths occurring between 1 January 1995 and 31 December 2015 in Denmark (n = 14,103) and a comparison subcohort comprised of a 5% random sample of the source population at baseline (n = 265,183). We quantified the joint effect of pairwise combinations of depression and major psychiatric disorders (e.g., organic disorders, substance use disorders, schizophrenia, bipolar disorder, neurotic disorders, eating disorders, personality disorders, intellectual disabilities, developmental disorders, and behavioral disorders) on suicide using marginal structural models and calculated the relative excess risk due to interaction. We assessed for the presence of competing antagonism for negative relative excess risk due to interactions.

Results:
All combinations of depression and comorbid psychiatric disorders were associated with increased suicide risk. For example, the rate of suicide among men with depression and neurotic disorders was 20 times (95% CI = 15, 26) the rate in men with neither disorder. Most disorder combinations were associated with subadditive suicide risk, and there was evidence of competing antagonism in most of these cases.

Conclusions:
Subadditivity may be explained by competing antagonism. When both depression and a comorbid psychiatric disorder are present, they may compete to cause the outcome such that having 2 disorders may be no worse than having a single disorder with respect to suicide risk.
Facial Skin Revitalization with Cohesive Polydensified Matrix-HA20G: Results from a Randomized Multicenter Clinical Study
Authors: Kerscher Martina , Prager Welf , Fischer Tanja C. , Gauglitz Gerd G. , Pavicic Tatjana , Kühne Ulrich , Kravtsov Maria , Hofmann Matthias , Dersch Hanna , Sattler Sonja 
Published: December 2021

Background:
There is a growing interest in the application of hyaluronic acid (HA) derivatives in skin quality improvement. The aim of this study was to confirm safety and effectiveness of cohesive polydensified matrix-hyaluronic acid + glycerol (CPM-HA20G; Belotero Revive) in revitalization of early-onset photodamaged facial skin.

Methods:
A total of 159 subjects with early signs of facial photodamaged skin were randomized in a 2:1 ratio to multiple- or single-dose treatment with CPMHA20G. Effectiveness assessments included biophysical measurements of skin hydration; elasticity, firmness, and roughness; investigator- and subject-assessed Global Aesthetic Improvement Scales; and FACE-Q Skin Changes and Treatment Satisfaction questionnaires.

Results:
In both treatment groups, skin hydration improved from baseline to all follow-up visits in subjects with dry or very dry skin. This improvement was significant at week 16 after initial treatment in the multiple-dose group (P = 0.0013). Investigator- and subject-reported outcomes showed that the majority of subjects across all skin hydration types benefited from treatment, with higher satisfaction rates observed in the multiple-dose group. According to investigator-assessed Global Aesthetic Improvement Scale, 90.7% of subjects at week 12 in the multiple-dose and 74.6% of subjects at week 4 in the single-dose group were rated as at least “improved.” All related treatment-emergent adverse events were transient, expected injection-site reactions of mild to moderate intensity.

Conclusions:
Effectiveness of CPM-HA20G for skin hydration in subjects with dry or very dry skin was demonstrated up to 9 months after last injection. Overall, CPM-HA20G demonstrated effective and safe use in facial skin revitalization among subjects with early-onset photodamaged skin.
POTENTIAL TREATMENT FOR PERIPAPILLARY PACHYCHOROID SYNDROME
Authors: Pothof Alexander B. , Fernández-Avellaneda Pedro , Behar-Cohen Francine , Martinez Ciriano José P. , Yzer Suzanne 
Published: December 2021

Purpose:
The purpose of this study was to describe the effect of topical prednisolone on intraretinal fluid in patients with peripapillary pachychoroid syndrome.

Methods:
We selected 11 consecutive patients (17 eyes) with a diagnosis of peripapillary pachychoroid syndrome, who were treated with topical prednisolone (Pred Forte [PF] 10 mg/mL) three times daily for 4 weeks. We tapered off PF among patients who demonstrated a reduction of intraretinal fluid.

Results:
Of the included 17 eyes, the average follow-up before PF treatment ranged from 6 to 192 months, during which patients experienced no apparent reduction of intraretinal fluid. The baseline mean best-corrected VA (BCVA) was 0.6 (20/33) Snellen. The median subfoveal and peripapillary choroidal thickness were 430 µm and 202 µm, respectively. All patients showed an initial reduction of intraretinal fluid after 4 weeks of topical prednisolone. Six patients (35%) experienced a prolonged reduction of intraretinal fluid when the dosage was reduced to once daily. On tapering off PF, four eyes (24%) experienced a recurrence of intraretinal fluid. Four eyes (24%) experienced elevated intraocular pressure above 26 mmHg. In two eyes, PF was discontinued, on which intraretinal fluid reappeared. The BCVA seemed to be improved in 9 eyes (53%) and remained equal in 4 eyes (24%).

Conclusion:
In this case series of patients with peripapillary pachychoroid syndrome, we observed a reduction of peripapillary intraretinal fluid after treatment with topical prednisolone for 4 weeks in all 17 eyes. The disappearance of intraretinal fluid seemed to concede with a slight improvement in BCVA for some cases. Thus, topical prednisolone may prove to be a viable treatment option in peripapillary pachychoroid syndrome.