bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of CCT3 as a prognostic factor and correlates with cell survival and invasion of head and neck squamous cell carcinoma
Authors: Wang Yan , Liu Peicheng , Zhang Ziwei , Wang Jiulong , Cheng Zhigang , Fan Chengchao 
Published: September 2021

Abstract
Background: Recurrent locally advanced or metastatic head and neck squamous cell carcinoma (HNSCC) is associated with dismal prognosis because of its highly invasive behavior and resistance to conventional intensive chemotherapy. The identification of effective markers for early diagnosis and prognosis is important for reducing mortality and ensuring that therapy for HNSCC is effective. Chaperonin-containing TCP-1 3 (CCT3) folds cancer-related proteins to control carcinogenesis. The prognostic value and growth association of CCT3 and HNSCC remain unknown.
Methods: The GEO, Oncomine and UALCAN databases were used to examine CCT3 expression in HNSCC. A few clinical HNSCC samples with normal tissues were used to detect CCT3 expression by using immunohistochemistry method. The TCGA-HNSC dataset was used to evaluate the association between expression of CCT3 and prognosis. The molecular mechanism was investigated with gene set enrichment analysis (GSEA). CCK-8 and wound healing assays were used to detect cell growth and invasion of HNSCC, respectively.
Results: CCT3 expression was significantly up-regulated in HNSCC in both mRNA and protein levels. In addition, up-regulated CCT3 expression was associated with various clinicopathological parameters. High expression of CCT3 was significantly correlated with inferior survival of HNSCC patients. Knockdown of CCT3 significantly inhibited cell growth and invasion of HNSCC cell lines. GSEA analysis indicated that CCT3 was closely correlated with tumor-related signaling pathways and HNSCC cell survival.
Conclusion: Our findings suggest that CCT3 is a biomarker of poor prognosis and related to the process of HNSCC.
DPANet: Dual Pooling‐aggregated Attention Network for fish segmentation
Authors: Zhang Wenbo , Wu Chaoyi , Bao Zhenshan 
Published: September 2021

AbstractThe sustainable development of marine fisheries depends on the accurate measurement of data on fish stocks. Semantic segmentation methods based on deep learning can be applied to automatically obtain segmentation masks of fish in images to obtain measurement data. However, general semantic segmentation methods cannot accurately segment fish objects in underwater images. In this study, a Dual Pooling‐aggregated Attention Network (DPANet) to adaptively capture long‐range dependencies through an efficient and computing‐friendly manner to enhance feature representation and improve segmentation performance is proposed. Specifically, a novel pooling‐aggregate position attention module and a pooling‐aggregate channel attention module are designed to aggregate contexts in the spatial dimension and channel dimension, respectively. These two modules adopt pooling operations along the channel dimension and along the spatial dimension to aggregate information, respectively, thus reducing computational costs. In these modules, attention maps are generated by four different paths and are aggregated into one. The authors conduct extensive experiments to validate the effectiveness of the DPANet and achieve new state‐of‐the‐art segmentation performance on the well‐known fish image dataset DeepFish as well as on the underwater image dataset SUIM, achieving a Mean IoU score of 91.08% and 85.39% respectively, while significantly reducing FLOPs of attention modules by about 93%.
Rotor electrical conductivity and eddy current loss analysis of high‐speed permanent magnet machine with a novel composite rotor
Authors: Luo Hao , Xu Zhenyao , Zhang Yue , Zhang He , Yu Qiuhong , Zhang Fengge 
Published: September 2021

AbstractThe high‐temperature rise of rotor permanent magnet (PM) in high‐speed PM machine (HSPMM) is one of the main bottlenecks that limits the development of HSPMM. The main reason for the increase of the PM temperature is the eddy current loss caused by high‐frequency harmonics. In this study, a new type of composite magnetic material is studied, which greatly reduces the electrical conductivity of the PM and thus reduces the eddy current loss under the condition of ensuring the magnetic properties. The electrical conductivity of magnetic powder composites is calculated by introducing the improved effective medium model of the magnetic powder packing coefficient. Through the calculation of the porosity of the magnetic powder composite, the effects of the particle size, gradation and shape of the magnetic powder on the electrical conductivity of the composite were obtained. The model solves the problem of calculating the electrical conductivity of the powder structure composite rotor in eddy current loss calculation. The accuracy of the calculation is verified by the four‐probe method, which provides guidance for the design of a composite rotor HSPMM.
Resilient service restoration for distribution systems with mobile resources using Floyd‐based network simplification method
Authors: Jiang Lizhou , Li Xin , Long Tao , Zhou Rongsheng , Jiang Jiangfeng , Bie Zhaohong , Tian Huili , Li Gengfeng , Ling Yuchang 
Published: September 2021

AbstractThe large‐scale blackouts of distribution systems (DS) caused by extreme natural disasters have aroused a lot of attention. To enhance the resilience of DSs, a novel service restoration and recovery model to minimize the system‐wide load loss is proposed here, where reconfiguration systems and two kinds of moveable resources, that is, mobile sources (MS) and repair crews (RC), are considered. Then, time‐space network (TSN) is applied to model the movement of MSs and RCs over the real‐world transportation networks (TN). However, the introduction of TSN makes solving the model become a time‐consuming task as plenty of variables are involved by it. To tackle this challenge which may lead to the impracticability of the model, a Floyd‐algorithm based TN simplification method is proposed to reduce the variables without sacrificing the equivalence of the TNs before and after the transformation. Finally, the applicability and effectiveness of the proposed model are verified on a 33‐bus test DS and a real‐world DS with complicated TNs.
Protostellar Interferometric Line Survey of the Cygnus X region (PILS-Cygnus)
Authors: van der Walt S. J. , Kristensen L. E. , Jørgensen J. K. , Calcutt H. , Manigand S. , el Akel M. , Garrod R. T. , Qiu K. 
Published: September 2021

Context. Complex organic molecules (COMs) are commonly detected in and near star-forming regions. However, the dominant process in the release of these COMs from the icy grains – where they predominately form – to the gas phase is still an open question.
Aims. We investigate the origin of COM emission in a high-mass protostellar source, CygX-N30 MM1, through high-angular-resolution interferometric observations over a continuous broad frequency range.
Methods. We used 32 GHz Submillimeter Array observations with continuous frequency coverage from 329 to 361 GHz at an angular resolution of ~1″ to do a line survey and obtain a chemical inventory of the source. The line emission in the frequency range was used to determine column densities and excitation temperatures for the COMs. We also mapped out the intensity distribution of the different species.
Results. We identified approximately 400 lines that can be attributed to 29 different molecular species and their isotopologues. We find that the molecular peak emission is along a linear gradient, and coincides with the axis of red- and blueshifted H2CO and CS emission. Chemical differentiation is detected along this gradient, with the O-bearing molecular species peaking towards one component of the system and the N- and S-bearing species peaking towards the other. The chemical gradient is offset from but parallel to the axis through the two continuum sources. The inferred column densities and excitation temperatures are compared to other sources where COMs are abundant. Only one deuterated molecule is detected, HDO, while an upper limit for CH2DOH is derived, leading to a D/H ratio of <0.1%.
Conclusions. We conclude that the origin of the observed COM emission is probably a combination of the young stellar sources along with accretion of infalling material onto a disc-like structure surrounding a young protostar and located close to one of the continuum sources. This disc and protostar are associated with the O-bearing molecular species, while the S- and N-bearing species on the other hand are associated with the other continuum core, which is probably a protostar that is slightly more evolved than the other component of the system. The low D/H ratio likely reflects a pre-stellar phase where the COMs formed on the ices at warm temperatures (~30 K), where the deuterium fractionation would have been inefficient. The observations and results presented here demonstrate the importance of good frequency coverage and high angular resolution when disentangling the origin of COM emission.
SWEET-Cat 2.0: The Cat just got SWEETer
Authors: Sousa S. G. , Adibekyan V. , Delgado-Mena E. , Santos N. C. , Rojas-Ayala B. , Soares B. M. T. B. , Legoinha H. , Ulmer-Moll S. , Camacho J. D. , Barros S. C. C. , Demangeon O. D. S. , Hoyer S. , Israelian G. , Mortier A. , Tsantaki M. , Monteiro M. A. 
Published: September 2021

Aims. The catalog of Stars With ExoplanETs (SWEET-Cat) was originally introduced in 2013. Since then many more exoplanets have been confirmed, increasing significantly the number of host stars listed there. A crucial step toward a comprehensive understanding of these new worlds is the precise and homogeneous characterization of their host stars. Better spectroscopic stellar parameters along with new results from Gaia eDR3 provide updated and precise parameters for the discovered planets. A new version of the catalog, whose homogeneity in the derivation of the parameters is key to unraveling star–planet connections, is available to the community.
Methods. We made use of high-resolution spectra for planet-host stars, either observed by our team or collected through public archives. The spectroscopic stellar parameters were derived for the spectra following the same homogeneous process using ARES and MOOG (ARES+MOOG) as for the previous SWEET-Cat releases. We re-derived parameters for the stars in the catalog using better quality spectra and/or using the most recent versions of the codes. Moreover, the new SWEET-Cat table can now be more easily combined with the planet properties listed both at the Extrasolar Planets Encyclopedia and at the NASA exoplanet archive to perform statistical analyses of exoplanets. We also made use of the recent Gaia eDR3 parallaxes and respective photometry to derive consistent and accurate surface gravity values for the host stars.
Results. We increased the number of stars with homogeneous parameters by more than 40% (from 645 to 928). We reviewed and updated the metallicity distributions of stars hosting planets with different mass regimes comparing the low-mass planets (< 30 M⊕) with the high-mass planets. The new data strengthen previous results showing the possible trend in the metallicity-period-mass diagram for low-mass planets.
Schmerztherapie bei nichtoperativen Patienten im Krankenhaus – Therapieansätze und Behandlungskompetenz im Schmerzdienst
Authors: Erlenwein Joachim , Petzke Frank 
Published: September 2021

ZusammenfassungPatienten nichtoperativer Abteilungen machen in den meisten Krankenhäusern einen relevanten Anteil an Patienten mit Schmerzen aus. Ziel dieses Beitrags ist es, eine Übersicht zu Therapieansätzen und Konzepten bei den nichtoperativen Schmerzentitäten für die Tätigkeit im Schmerzdienst oder im Bereitschaftsdienst zu geben.
Auf dem Weg zur sexuellen Selbstbestimmung: Das Engagement der Bundeszentrale für gesundheitliche Aufklärung (BZgA) für Menschen mit Beeinträchtigungen
Authors: Scharmanski Sara , Paschke Stefanie , Tomse Mirjam , Brockschmidt Laura 
Published: September 2021

ZusammenfassungJeder Mensch hat das Recht auf den Zugang zu evidenzbasierten Informationen zur Sexualaufklärung, Verhütung und Familienplanung. Im Sinne eines ganzheitlichen Verständnisses von sexueller und reproduktiver Gesundheit fördert die Bundeszentrale für gesundheitliche Aufklärung (BZgA) mit ihren Maßnahmen das Recht auf eine selbstbestimmte Sexualität von Menschen mit Beeinträchtigungen. Der vorliegende Praxisbeitrag stellt diese Aktivitäten und Materialien zusammenfassend dar.
Sexuelle Selbstbestimmung für Menschen mit Behinderungen
Authors: Specht Ralf 
Published: September 2021

ZusammenfassungSexuelle Selbstbestimmung wurde Menschen mit Behinderungen lange nicht zugestanden. Gleichzeitig wurde auch die Tatsache, dass Menschen mit Behinderungen ein mehrfach erhöhtes Risiko haben, Opfer sexueller Gewalt zu werden, fast gänzlich ignoriert. Das ändert sich zum Glück in zunehmendem Maße. Das kurz als „Behindertenrechtskonvention“ bekannte „Übereinkommen über die Rechte von Menschen mit Behinderungen“ der Vereinten Nationen verbrieft seit 2009 das Recht auf Selbstbestimmung als Menschenrecht auch in Deutschland. Dies gilt nicht zuletzt für den Lebensbereich der Sexualität, obwohl dieser nicht explizit genannt wird. Der vorliegende Praxisbeitrag skizziert – auch mit historischen Rückblicken – die aktuelle Situation und gibt Handlungsempfehlungen insbesondere für die institutionelle Praxis.
Sexualisierte Gewalt gegen Kinder und Jugendliche mit Behinderungen: Erweiterter Forschungsstand seit 2014 und praktische Konsequenzen
Authors: Chodan Wencke , Häßler Frank , Reis Olaf 
Published: September 2021

Zusammenfassung
Einleitung Kinder und Jugendliche mit Behinderungen stellen eine Hochrisikogruppe dar, die signifikant häufiger von sexualisierter Gewalt betroffen ist als Kinder und Jugendliche ohne Behinderungen.
Forschungsziele Das vorliegende narrative Review aktualisiert den Überblick über die internationale Forschungslage zu Prävalenz, Risikofaktoren und Interventionen von und bei sexualisierter Gewalt gegen Kinder und Jugendliche mit Behinderungen.
Methoden Durch systematische Recherchen in Pubmed, PsycINFO und verschiedenen Suchmaschinen wurden 39 Publikationen extrahiert, die seit 2014 das Themenfeld der sexualisierten Gewalt gegen Kinder und Jugendliche mit Behinderungen beleuchten und damit einen Reviewartikel von 2014 aktualisieren.
Ergebnisse Die eingeschlossenen 39 Artikel wurden in die Bereiche Epidemiologie (Prävalenz n = 17, Risikofaktoren n = 5, Folgen sexualisierter Gewalt n = 2), Versorgung (Prävention n = 7, Intervention n = 6) und Verschiedenes (n = 2) unterteilt. Eine aktuelle Metaanalyse unterstreicht das erhöhte Risiko für Kinder und Jugendliche mit Behinderungen im Vergleich zu Gleichaltrigen ohne Behinderungen, von sexualisierter Gewalt betroffen zu werden. Zwei neu entwickelte, strukturierte und evaluierte Präventionsprogramme treten diesem Risiko entgegen. Für die Versorgung von Kindern und Jugendlichen nach dem Erleben von sexualisierter Gewalt gibt es lediglich für Kinder und Jugendliche mit Hörbehinderungen eine Publikation mit konkreten Hinweisen; für alle anderen Behinderungsformen ließ sich auch seit 2014 kein evaluiertes Programm auffinden.
Schlussfolgerung Implikationen für künftige Forschung zu sexualisierter Gewalt gegen Kinder und Jugendliche mit Behinderungen und deren Versorgung werden diskutiert.
Does Neuromuscular Electrical Stimulation Have an Additive Effect on Disability, Pain and Abdominal and Lumbar Muscle Thickness in Chronic Low Back Pain? – A Randomized Controlled Double-Blind Study
Authors: Atli Ecenur , Coskunsu Dilber Karagozoglu , Turan Zeynep , Taskiran Ozden Ozyemisci 
Published: September 2021

Abstract
Objective To examine the effect of neuromuscular electrical stimulation (NMES) combined with core stabilization exercises (CSE) in patients with chronic low back pain (CLBP).
Methods Thirty-six patients (mean age 33.6±12.6 years) with CLBP were randomly assigned to 4 weeks (12 sessions) of NMES group (NMES combined with CSE) (n=18) vs. Control group (sham NMES and CSE) (n=18). After the 4 weeks, same exercises were given as home exercise program without NMES. The outcome measures were Oswestry Disability Index (ODI), Visual Analog Scale (VAS), Nottingham Health Profile (NHP) and ultrasonography. Ultrasonography was used for measuring transversus abdominis (TrA), internal oblique (IO), external oblique (EO) muscles thickness and lumbar multifidus muscle thickness and area. Assessments were performed at baseline and 4th week and eighth week follow-up.
Results In both groups, the change of ODI, VAS and NHP values of the first measurement according to the values of the 4th week and the eighth week were found statistically significant (p=0.001; p<0.01). There were no statistically significant differences in ODI, VAS and NHP scores between the 4th week and the eighth week in both groups (p>0.05). None of NMES and control group measurements with US showed a statistically significant increase in the TrA, IO, EO thickness and multifidus thickness and area (p>0.05).
Conclusions It was shown that NMES can be tolerated by patients with CLBP, but the addition of simultaneus NMES to CSE had no contribution to the clinical outcome measures.
Platelet Activation and Reactivity in a Large Cohort of Patients with Gaucher Disease
Authors: Revel-Vilk Shoshana , Naamad Mira , Frydman Dafna , Freund Michael R. , Dinur Tama , Istaiti Majdolen , Becker-Cohen Michal , Falk Roni , Broide Eti , Michelson Alan D. , Frelinger Andrew L. , Zimran Ari 
Published: September 2021

Abstract
Objectives Patients with Gaucher disease (GD) are at increased risk of bleeding and have varying degrees of thrombocytopenia, making the analysis of platelet function difficult. This study aimed to provide a clinically relevant quantitative assessment of platelet function and determine its relationship with bleeding and GD-related data.
Methods Unstimulated and stimulated platelet function was measured by whole blood flow cytometry of platelet surface-activated αIIbβ3 integrin (detected with monoclonal antibody PAC1), P-selectin (CD62P), and lysosomal-associated membrane protein (LAMP3/CD63) in 149 GD patients.
Results GD patients had a higher level of unstimulated CD63 expression than healthy subjects, which was mildly correlated with glucosylsphingosine (lyso-Gb1) levels (r = 0.17, p-value = 0.042). Splenectomized GD patients had a higher level of unstimulated αIIbβ3 integrin and P-selectin expression. Reduced platelet reactivity (−2 standard deviation of reference range) was found in 79 (53%, 95% confidence interval [CI]: 44–61%) patients, of whom 10 (6.7%, 95% CI: 3.3–12%) had more severe platelet dysfunction. In a multivariate model, only lyso-Gb1 levels were associated with the more severe platelet dysfunction. Fifty-four (49%) of 128 adult patients who completed the bleeding tendency questionnaire reported positive bleeding history. In a multivariate logistic model, older age (odds ratio [OR]: 1.05, 95% CI: 1.01–1.1) and low P-selectin reactivity (OR: 2.03, 95% CI: 1.25–3.35) were associated with more than one bleeding manifestation.
Conclusion Flow cytometry enables the study of platelet function in thrombocytopenic GD patients. A platelet degranulation defect, but not αIIbβ3 integrin activation defect, is associated with clinical bleeding. In vivo increased CD63 expression may be related to GD-related inflammation.
Ligament Balancing and Constraint in Revision Total Knee Arthroplasty
Authors: Crawford David A. , Lombardi Adolph V. 
Published: September 2021

AbstractLigament balancing in revision knee arthroplasty is crucial to the success of the procedure. The medial collateral ligament and lateral ligament complex are the primary ligamentous structures that provide stability. Revisions can be performed with nonconstrained cruciate-retaining, posterior cruciate substituting, or anterior-stabilized/ultracongruent inserts when there are symmetrical flexion/extension gaps and intact collateral ligaments. When the collateral ligaments are insufficient either due to attenuation or incompetence from bone loss, a more constrained knee system is needed. Constrained condylar knees provide increased stability to both varus/valgus and rotation forces with a nonlinked construct. This increased constraint, however, does lead to increased stress at the implant–bone interface which requires more robust metaphyseal fixation. In cases of significant soft tissue disruption, severe flexion/extension gap mismatch or extensor mechanism disruption, a rotating hinge knee is needed to restore stability. Advances in revision implant design have led to improved outcomes and longer survivorship then earlier iterations of these implants. Surgeons should always strive to use the least constraint needed to achieve stability but must have a low threshold to increase constraint when ligament integrity is compromised.
The Epidemiology of Revision Total Knee Arthroplasty
Authors: Tarazi John M. , Chen Zhongming , Scuderi Giles R. , Mont Michael A. 
Published: September 2021

AbstractWith an expected increase in total knee arthroplasty (TKA) procedures, revision TKA (rTKA) procedures continue to be a burden on the United States health care system. The evolution of surgical techniques and prosthetic designs has, however, provided a paradigm shift in the etiology of failure mechanisms of TKA. This review can shed light on the current reasons for revision, which may lead to insights on how to improve outcomes and lower future revision risks. We will primarily focus on the epidemiology of rTKA in the present time, but we will also review this in the context of various time periods to see how the field has evolved. We will review rTKAs: 1) prior to 1997; 2) between 1997 and 2000; 3) between 2000 and 2012; and 3) in the modern era since 2012. We will further subdivide each of the sections into reasons for early (first 2 years after index procedure) versus late revisions (greater than 2 years after index procedure). In doing so, it was determined that prior to 1997, the most prevalent causes of failure were infection, patella failure, polyethylene wear, and aseptic loosening. After a major shift of failure mechanisms was described by Sharkey et al, polyethylene wear and aseptic loosening became the leading causes for revision. However, with the improved manufacturing technology and implant design, polyethylene wear was replaced with aseptic loosening and infection as the leading causes of failure between 2000 and 2012. Since that time, in the modern era of TKA, mechanical loosening and infection have taken over the most prevalent causes for failure. Hopefully, with continued developments in component design and surgical techniques, as well as increased focus on infection reduction methods, the amount of rTKA procedures will decline.