bluuebunny/crossref_metadata_2025_split huggingface dataset:
Olivine-rich achondrites from Vesta and the missing mantle problem
Authors: Vaci Zoltan , Day James M. D. , Paquet Marine , Ziegler Karen , Yin Qing-Zhu , Dey Supratim , Miller Audrey , Agee Carl , Bartoschewitz Rainer , Pack Andreas 
Published: September 2021

AbstractMantles of rocky planets are dominantly composed of olivine and its high-pressure polymorphs, according to seismic data of Earth’s interior, the mineralogy of natural samples, and modelling results. The missing mantle problem represents the paucity of olivine-rich material among meteorite samples and remote observation of asteroids, given how common differentiated planetesimals were in the early Solar System. Here we report the discovery of new olivine-rich meteorites that have asteroidal origins and are related to V-type asteroids or vestoids. Northwest Africa 12217, 12319, and 12562 are dunites and lherzolite cumulates that have siderophile element abundances consistent with origins on highly differentiated asteroidal bodies that experienced core formation, and with trace element and oxygen and chromium isotopic compositions associated with the howardite-eucrite-diogenite meteorites. These meteorites represent a step towards the end of the shortage of olivine-rich material, allowing for full examination of differentiation processes acting on planetesimals in the earliest epoch of the Solar System.
Supervision of a self-driving vehicle unmasks latent sleepiness relative to manually controlled driving
Authors: Flynn-Evans Erin E. , Wong Lily R. , Kuriyagawa Yukiyo , Gowda Nikhil , Cravalho Patrick F. , Pradhan Sean , Feick Nathan H. , Bathurst Nicholas G. , Glaros Zachary L. , Wilaiprasitporn Theerawit , Bansal Kanika , Garcia Javier O. , Hilditch Cassie J. 
Published: September 2021

AbstractHuman error has been implicated as a causal factor in a large proportion of road accidents. Automated driving systems purport to mitigate this risk, but self-driving systems that allow a driver to entirely disengage from the driving task also require the driver to monitor the environment and take control when necessary. Given that sleep loss impairs monitoring performance and there is a high prevalence of sleep deficiency in modern society, we hypothesized that supervising a self-driving vehicle would unmask latent sleepiness compared to manually controlled driving among individuals following their typical sleep schedules. We found that participants felt sleepier, had more involuntary transitions to sleep, had slower reaction times and more attentional failures, and showed substantial modifications in brain synchronization during and following an autonomous drive compared to a manually controlled drive. Our findings suggest that the introduction of partial self-driving capabilities in vehicles has the potential to paradoxically increase accident risk.
Spatiotemporal beam self-cleaning for high-resolution nonlinear fluorescence imaging with multimode fiber
Authors: Moussa Nawell Ould , Mansuryan Tigran , Hage Charles-Henri , Fabert Marc , Krupa Katarzyna , Tonello Alessandro , Ferraro Mario , Leggio Luca , Zitelli Mario , Mangini Fabio , Niang Alioune , Millot Guy , Papi Massimiliano , Wabnitz Stefan , Couderc Vincent 
Published: September 2021

AbstractBeam self-cleaning (BSC) in graded-index (GRIN) multimode fibers (MMFs) has been recently reported by different research groups. Driven by the interplay between Kerr effect and beam self-imaging, BSC counteracts random mode coupling, and forces laser beams to recover a quasi-single mode profile at the output of GRIN fibers. Here we show that the associated self-induced spatiotemporal reshaping allows for improving the performances of nonlinear fluorescence (NF) microscopy and endoscopy using multimode optical fibers. We experimentally demonstrate that the beam brightness increase, induced by self-cleaning, enables two and three-photon imaging of biological samples with high spatial resolution. Temporal pulse shortening accompanying spatial beam clean-up enhances the output peak power, hence the efficiency of nonlinear imaging. We also show that spatiotemporal supercontinuum (SC) generation is well-suited for large-band NF imaging in visible and infrared domains. We substantiated our findings by multiphoton fluorescence imaging in both microscopy and endoscopy configurations.
Community-driven tree planting greens the neighbouring landscape
Authors: Buxton Joshua , Powell Tom , Ambler John , Boulton Chris , Nicholson Arwen , Arthur Rudy , Lees Kirsten , Williams Hywel , Lenton Timothy M. 
Published: September 2021

AbstractNature-based solutions to climate change are growing policy priorities yet remain hard to quantify. Here we use remote sensing to quantify direct and indirect benefits from community-led agroforestry by The International Small group and Tree planting program (TIST) in Kenya. Since 2005, TIST-Kenya has incentivised smallholder farmers to plant trees for agricultural benefit and to sequester CO2. We use Landsat-7 satellite imagery to examine the effect on the historically deforested landscape around Mount Kenya. We identify positive greening trends in TIST groves during 2000–2019 relative to the wider landscape. These groves cover 27,198 ha, and a further 27,750 ha of neighbouring agricultural land is also positively influenced by TIST. This positive ‘spill-over’ impact of TIST activity occurs at up to 360 m distance. TIST also benefits local forests, e.g. through reducing fuelwood and fodder extraction. Our results show that community-led initiatives can lead to successful landscape-scale regreening on decadal timescales.
Longitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children
Authors: Carreras-Badosa Gemma , Gómez-Vilarrubla Ariadna , Mas-Parés Berta , Xargay-Torrent Silvia , Prats-Puig Anna , Puerto-Carranza Elsa , de Zegher Francis , Ibáñez Lourdes , Bassols Judit , López-Bermejo Abel 
Published: September 2021

AbstractBoth the innate and adaptive immune responses are deregulated in individuals with obesity and are key drivers of its associated metabolic alterations. Although the anti-inflammatory growth differentiation factor 15 (GDF-15) is a candidate protein against obesity, its mechanisms regulating the immune responses are not fully cleared. We examined whether GDF-15 was related to serum immunoglobulins in a children’s cohort assessed longitudinally during childhood. Results showed that circulating GDF-15 positively associated with IgA (p < 0.002) and IgG (p < 0.001) levels and the IgA*IgG product (p < 0.001) in apparently healthy children at both baseline (age 9) and follow-up (age 13). The associations were readily observed in heavier children (those with BMI-SDS above the median) as well as in children with higher renal fat accumulation (those with renal fat-to-height ratio above the median) and remained significant after correcting for possible confounding variables. Serum GDF-15 levels accounted for up to 16% of the variance of follow-up IgG levels and up to 14% of the variance of follow-up IgA*IgG product. The longitudinal associations of the anti-inflammatory GDF-15 with IgA, IgG and the IgA*IgG product in children with higher BMI or higher renal fat accumulation suggest a role of GDF-15 in human obesity through the regulation of the immune adaptive system.
Football player dominant region determined by a novel model based on instantaneous kinematics variables
Authors: Caetano Fabio Giuliano , Barbon Junior Sylvio , Torres Ricardo da Silva , Cunha Sergio Augusto , Ruffino Paulo Régis Caron , Martins Luiz Eduardo Barreto , Moura Felipe Arruda 
Published: September 2021

AbstractDominant regions are defined as regions of the pitch where a player can reach before any other and are commonly determined without considering the free-spaces in the pitch. We presented an approach to football players’ dominant regions analysis, based on movement models created from players’ positions, displacement, velocity, and acceleration vectors. 109 Brazilian male professional football players were analysed during official matches, computing over 15 million positional data obtained by video-based tracking system. Movement models were created based on players’ instantaneous vectorial kinematics variables, then probabilities models and dominant regions were determined. Accuracy in determining dominant regions by the proposed model was tested for different time-lag windows. We calculated the areas of dominant, free-spaces, and Voronoi regions. Mean correct predictions of dominant region were 96.56%, 88.64%, and 72.31% for one, two, and three seconds, respectively. Dominant regions areas were lower than the ones computed by Voronoi, with median values of 73 and 171 m2, respectively. A median value of 5537 m2 was presented for free-space regions, representing a large part of the pitch. The proposed movement model proved to be more realistic, representing the match dynamics and can be a useful method to evaluate the players’ tactical behaviours during matches.
National interest may require distributing COVID-19 vaccines to other countries
Authors: Rotesi Tiziano , Pin Paolo , Cucciniello Maria , Malik Amyn A. , Paintsil Elliott E. , Bokemper Scott E. , Willebrand Kathryn , Huber Gregory A. , Melegaro Alessia , Omer Saad B. 
Published: September 2021

AbstractAs immunization campaigns are accelerating, understanding how to distribute the scarce doses of vaccines is of paramount importance and a quantitative analysis of the trade-offs involved in domestic-only versus cooperative distribution is still missing. In this study we use a network Susceptible-Infected-Removed (SIR) model to show circumstances under which it is in a country’s self-interest to ensure other countries can obtain COVID-19 vaccines rather than focusing only on vaccination of their own residents. In particular, we focus our analysis on the United States and estimate the internal burden of COVID-19 disease under different scenarios about vaccine cooperation. We show that in scenarios in which the US has reached the threshold for domestic herd immunity, the US may find it optimal to donate doses to other countries with lower vaccination coverage, as this would allow for a sharp reduction in the inflow of infected individuals from abroad.
SARS-CoV-2 infection hospitalization, severity, criticality, and fatality rates in Qatar
Authors: Seedat Shaheen , Chemaitelly Hiam , Ayoub Houssein H. , Makhoul Monia , Mumtaz Ghina R. , Al Kanaani Zaina , Al Khal Abdullatif , Al Kuwari Einas , Butt Adeel A. , Coyle Peter , Jeremijenko Andrew , Kaleeckal Anvar Hassan , Latif Ali Nizar , Shaik Riyazuddin Mohammad , Yassine Hadi M. , Al Kuwari Mohamed G. , Al Romaihi Hamad Eid , Al-Thani Mohamed H. , Bertollini Roberto , Abu-Raddad Laith J. 
Published: September 2021

AbstractThe SARS-CoV-2 pandemic resulted in considerable morbidity and mortality as well as severe economic and societal disruptions. Despite scientific progress, true infection severity, factoring both diagnosed and undiagnosed infections,
remains poorly understood. This study aimed to estimate SARS-CoV-2 age-stratified and overall morbidity and mortality rates based on analysis of extensive epidemiological data for the pervasive epidemic in Qatar, a country where < 9% of the population are ≥ 50 years. We show that SARS-CoV-2 severity and fatality demonstrate a striking age dependence with low values for those aged < 50 years, but rapidly growing rates for those ≥ 50 years. Age dependence was particularly pronounced for infection criticality rate and infection fatality rate. With Qatar’s young population, overall SARS-CoV-2 severity and fatality were not high with < 4 infections in every 1000 being severe or critical and < 2 in every 10,000 being fatal. Only 13 infections in every 1000 received any hospitalization in acute-care-unit beds and < 2 in every 1000 were hospitalized in intensive-care-unit beds. However, we show that these rates would have been much higher if Qatar’s population had the demographic structure of Europe or the United States. Epidemic expansion in nations with young populations may lead to considerably lower disease burden than currently believed.
Analysis of weighted gene co-expression network of triterpenoid-related transcriptome characteristics from different strains of Wolfiporia cocos
Authors: Zeng Guiping , Li Zhong , Zhao Zhi 
Published: September 2021

AbstractThe fungus Wolfiporia cocos has wide-ranging and important medicinal value, and its dried sclerotia are used as a traditional Chinese medicine. Modern studies have shown that triterpenoid, the active ingredient of W. cocos, have a variety of pharmacological effects. The aim of our research was to determine the key genes related to triterpenoid biosynthesis, which may be useful for the genetic modification of cell-engineered bacteria for triterpenoid biosynthesis. In this study, two monospore strains, DZAC-WP-H-29 (high-yielding) and DZAC-WP-L-123 (low-yielding), were selected from the sexually propagated offspring of strain 5.78 of W. cocos, and the mycelia were cultured for 17, 34, and 51 days, respectively. Weighted gene co-expression network analysis (WGCNA) method was used to analyze transcriptional expressions. The results show that eight core genes (ACAT1-b, hgsA, mvd1, SQLE, erg6, TAT, erg26, and erg11) are associated with the triterpenoid synthesis pathway, and Pm20d2 and norA outside the pathway may be important genes that influence the biosynthesis and accumulation of W. cocos triterpenoid. The biosynthesis of W. cocos triterpenoid is closely related to the expression of sterol metabolic pathway genes. The role of these genes in triterpenoid synthesis complements our knowledge on the biosynthesis and accumulation of W. cocos triterpenoid, and also provides a reference for the target gene modification of engineered bacteria for the fermentation production of triterpenoid.
Plant biodiversity assessment through pollen DNA metabarcoding in Natura 2000 habitats (Italian Alps)
Authors: Leontidou Kleopatra , Vokou Despoina , Sandionigi Anna , Bruno Antonia , Lazarina Maria , De Groeve Johannes , Li Mingai , Varotto Claudio , Girardi Matteo , Casiraghi Maurizio , Cristofori Antonella 
Published: September 2021

AbstractMonitoring biodiversity is of increasing importance in natural ecosystems. Metabarcoding can be used as a powerful molecular tool to complement traditional biodiversity monitoring, as total environmental DNA can be analyzed from complex samples containing DNA of different origin. The aim of this research was to demonstrate the potential of pollen DNA metabarcoding using the chloroplast trnL partial gene sequencing to characterize plant biodiversity. Collecting airborne biological particles with gravimetric Tauber traps in four Natura 2000 habitats within the Natural Park of Paneveggio Pale di San Martino (Italian Alps), at three-time intervals in 1 year, metabarcoding identified 68 taxa belonging to 32 local plant families. Metabarcoding could identify with finer taxonomic resolution almost all non-rare families found by conventional light microscopy concurrently applied. However, compared to microscopy quantitative results, Poaceae, Betulaceae, and Oleaceae were found to contribute to a lesser extent to the plant biodiversity and Pinaceae were more represented. Temporal changes detected by metabarcoding matched the features of each pollen season, as defined by aerobiological studies running in parallel, and spatial heterogeneity was revealed between sites. Our results showcase that pollen metabarcoding is a promising approach in detecting plant species composition which could provide support to continuous monitoring required in Natura 2000 habitats for biodiversity conservation.
Evaluation of acute and subacute toxicity of ethanolic extract and fraction of alkaloids from bark of Aspidosperma nitidum in mice
Authors: Brígido Heliton Patrick Cordovil , Varela Everton Luiz Pompeu , Gomes Antônio Rafael Quadros , Bastos Mirian Letícia Carmo , de Oliveira Feitosa Andre , do Rosário Marinho Andrey Moacir , Carneiro Liliane Almeida , Coelho-Ferreira Márlia Regina , Dolabela Maria Fâni , Percário Sandro 
Published: September 2021

AbstractThis study investigated the acute and subacute toxicity of the ethanolic extract (EE) and alkaloid fraction (FA) from A. nitidum. The EE was obtained from trunk bark with ethanol, FA was obtained from the fractionation of EE. To test the acute toxicity, mice were divided into four groups, and the negative controls received water or aqueous solution of dimethyl sulfoxide, whereas the others received EE or FA (2000 mg/kg, orally, single dose). The same controls were used in the subacute trial. However, the animals were treated for 28 days, and the dose used was 1000 mg/kg per day of EE and FA. Daily clinical evaluations of the animals were performed. At the end of the experiment, hematological, biochemical, and histopathological assessments (liver, lung, heart, and kidney) were performed. In the acute and subacute toxicity studies, mice treated with EE and FA did not show any clinical changes, there were no changes in weight gain, hematological and biochemical parameters compared to the control groups (p > 0.05). In the histopathological examination, there was no abnormality in the organs of the treated animals. Therefore, EE and FA did not produce toxic effects in mice after acute and subacute treatment.
The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma
Authors: Liu Jixuan , Ban Hongyan , Liu Yafang , Ni Jinsong 
Published: September 2021

AbstractAldosterone reductase family 1 member B10 (AKR1B10) is a nicotinamide adenine dinucleotide phosphate (reduced coenzyme II)-dependent oxidoreductase, and its biological functions include carbonyl detoxification, hormone metabolism, osmotic adjustment, and lipid synthesis. Studies suggested that AKR1B10 is a new biomarker for cancer based on its overexpression in epithelial tumors, such as breast cancer, cervical cancer, and lung cancer. At present, studies on the expression of AKR1B10 in laryngeal cancer have not been reported. However, we found that AKR1B10 is upregulated in laryngeal carcinoma, and its expression was negatively correlated with the degree of differentiation. In addition, AKR1B10 expression was positively correlated with tumor size; lymph node metastasis; alcohol use; and Ki-67, mutant p53, and matrix metalloproteinase 2 expression. AKR1B10 was overexpressed in Hep-2 laryngeal carcinoma cells. Oleanolic acid inhibited AKR1B10 activity and expression in Hep-2 cells and suppressed Hep-2 cell proliferation, migration, and invasion. Therefore, AKR1B10 may be related to the development of laryngeal carcinoma, suggesting its use as a prognostic indicator for laryngeal cancer.
Novel cryo-EM structure of an ADP-bound GroEL–GroES complex
Authors: Kudryavtseva Sofia S. , Pichkur Evgeny B. , Yaroshevich Igor A. , Mamchur Aleksandra A. , Panina Irina S. , Moiseenko Andrei V. , Sokolova Olga S. , Muronetz Vladimir I. , Stanishneva-Konovalova Tatiana B. 
Published: September 2021

AbstractThe GroEL–GroES chaperonin complex is a bacterial protein folding system, functioning in an ATP-dependent manner. Upon ATP binding and hydrolysis, it undergoes multiple stages linked to substrate protein binding, folding and release. Structural methods helped to reveal several conformational states and provide more information about the chaperonin functional cycle. Here, using cryo-EM we resolved two nucleotide-bound structures of the bullet-shaped GroEL–GroES1 complex at 3.4 Å resolution. The main difference between them is the relative orientation of their apical domains. Both structures contain nucleotides in cis and trans GroEL rings; in contrast to previously reported bullet-shaped complexes where nucleotides were only present in the cis ring. Our results suggest that the bound nucleotides correspond to ADP, and that such a state appears at low ATP:ADP ratios.
The comparison of censored quantile regression methods in prognosis factors of breast cancer survival
Authors: Yazdani Akram , Yaseri Mehdi , Haghighat Shahpar , Kaviani Ahmad , Zeraati Hojjat 
Published: September 2021

AbstractThe Cox proportional hazards model is a widely used statistical method for the censored data that model the hazard rate rather than survival time. To overcome complexity of interpreting hazard ratio, quantile regression was introduced for censored data with more straightforward interpretation. Different methods for analyzing censored data using quantile regression model, have been introduced. The quantile regression approach models the quantile function of failure time and investigates the covariate effects in different quantiles. In this model, the covariate effects can be changed for patients with different risk and is a flexible model for controlling the heterogeneity of covariate effects. We illustrated and compared five methods in quantile regression for right censored data included Portnoy, Wang and Wang, Bottai and Zhang, Yang and De Backer methods. The comparison was made through the use of these methods in modeling the survival time of breast cancer. According to the results of quantile regression models, tumor grade and stage of the disease were identified as significant factors affecting 20th percentile of survival time. In Bottai and Zhang method, 20th percentile of survival time for a case with higher unit of stage decreased about 14 months and 20th percentile of survival time for a case with higher grade decreased about 13 months. The quantile regression models acted the same to determine prognostic factors of breast cancer survival in most of the time. The estimated coefficients of five methods were close to each other for quantiles lower than 0.1 and they were different from quantiles upper than 0.1.
Mortality is not associated with paclitaxel-coated devices usage in peripheral arterial disease of lower extremities
Authors: Ko Dai Sik , Bae Gi Hwan , Choi Sang Tae , Jung Jaehun , Kang Jin Mo 
Published: September 2021

AbstractA recent meta-analysis addressed increased risk of death following revascularization with paclitaxel-coated devices in femopopliteal artery. We evaluated differences in all-cause mortality and amputation free survival between peripheral arterial disease (PAD) patients who were treated with paclitaxel-coated devices and non-paclitaxel-coated devices. This was retrospective population-based cohort study from the National Health Insurance Service claims in South Korea from 2015 to 2019. Multivariate Cox regression analyses after propensity score matching were applied to identify all-cause mortality and amputation-free survival. After propensity score matching, there were 6090 patients per group. The median follow-up days was 580 days (interquartile range [IQR] 240–991 days) and 433 days (IQR 175–757 days) for the non-paclitaxel-coated device group and paclitaxel-coated device group, respectively. Multivariate analysis adjusted for age, sex, diabetes, hypertension, warfarin, and new oral anticoagulants showed that the mortality rate associated with paclitaxel-coated devices was not significantly higher than non-paclitaxel-coated devices (hazard ratio [HR] 0.992; 95% CI 0.91–1.08). The rate of amputation events was higher in patients with paclitaxel-coated devices than those with non-paclitaxel-coated devices (HR 1.614; 95% CI 1.46–1.78). In this analysis, the mortality rate in patients with PAD was not associated with the use of paclitaxel-coated devices, despite a higher amputation rate.