bluuebunny/crossref_metadata_2025_split huggingface dataset:
Аpplication of nifuratel in treatment of cystitis in women
Authors: Melnik E. G. 
Published: September 2021

Cystitis is the most common pathology of the urinary tract in women both in our country and abroad. The high incidence of this disease in women in the population is influenced by anatomical, physiological features of the female body, violations of personal and sexual hygiene, burdened with an obstetric and gynecological (OAG) history, etc. In the current domestic and foreign recommendations for the diagnosis and treatment of cystitis in women, it is noted that in the vast majority of cases (up to 80% cases), the causative agent of cystitis is Escherichia coli, sensitive to nitrоfuran drugs.The purpose of the work. To demonstrate the effectiveness of the use of nifuratel (Nifuratel-SZ, Northern Star Co., Russia) in women with cystitis of various age groups using clinical examples. In the first clinical example, the high effectiveness of the use of nitrоfuran was shown in a woman of active reproductive age with OAG, in the second, in a teenager with an acute inflammatory process, in the 3rd-in a postmenopausal patient with concomitant multiple organ pathology.Conclusion. Nifuratel (Nifuratel-SZ, Northern Star Co., Russia) has proven to be a highly effective and safe drug with a wide range of antibacterial effects in patients with cystitis of different age groups.
Optimization of therapeutic and diagnostic approaches and possibility of predicting degree of risk of violation of vaginal microbiota
Authors: Khuraseva A. B. , Reminnaya T. V. 
Published: September 2021

Goal. Optimization of the effectiveness of diagnosis and prediction of the degree of risk of violation of the vaginal microbiota.Materials and methods. 572 patients were examined with complaints of copious discharge from the genital tract and/or an unpleasant smell. All women were observed in accordance with anamnestic, clinical, and laboratory criteria.Results and conclusions. When examining patients, the results of anamnestic, clinical and laboratory signs were evaluated according to a point system, taking into account their informative value and the probability of influencing the vaginal microbiome. Based on the data analysis, a method for predicting the degree of risk of violation of the vaginal microbiota was proposed. The method allows for a personalized therapeutic and diagnostic approach and allows predicting the risk of violation of the vaginal microbiota as early as possible.
Depression Survivors Among Emerging Adults: Their Healing Journey
Authors: Pui Wei Zhe , Saili Jamayah 
Published: September 2021

This qualitative study explored the healing process of depression survivors among emerging adults with effective coping strategies utilised by them. A semi-structured interview was conducted on participants aged between 18-28 years old. A theme narrating the experience of the depression survivors were identified: The journey of healing - Crawling out of the quicksand. The survivors emphasised that to achieve healing, everything starts from within the self, and they had been putting in a lot of their extra efforts in helping themselves heal. They all went beyond recovery, where their efforts illustrated their focus on healing, thriving, and achieving optimal well-being upon recovery. Significantly, the relevance and applicability of the building blocks of Seligman’s PERMA model of well-being towards those efforts taken were revealed in the study.
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Efficient and Consistent Orthotopic Osteosarcoma Model by Cell Sheet Transplantation in the Nude Mice for Drug Testing
Authors: Wu Hongwei , He Zhengxi , Li Xianan , Xu Xuezheng , Zhong Wu , Bu Jie , Huang Gang 
Published: September 2021

Osteosarcoma is a big challenge on clinical treatment. The breakthrough associated with osteosarcoma in basic research and translational research depends on the reliable establishment of an animal model, whereby mice are frequently used. However, a traditional animal modeling technique like tumor cell suspension injection causes batch dynamics and large mice consumption. Here, we suggested a novel approach in establishing an orthotropic osteosarcoma model in nude mice rapidly by cell sheet culture and transplantation. Our findings demonstrated that the 143b osteosarcoma cell sheet orthotopically implanted into the nude mice could form a visible mass within 10 days, whereas it took over 15 days for a similar amount of cell suspension injection to form a visible tumor mass. Living animal imaging results showed that a tumor formation rate was 100% in the cell sheet implantation group, while it was 67% in the cell suspension injection group. The formed tumor masses were highly consistent in both growth rate and tumor size. Massive bone destruction and soft tissue mass formation were observed from the micro CT analysis, suggesting the presence of osteosarcoma. The histopathological analysis demonstrated that the orthotropic osteosarcoma model mimicked the tumor bone growth, bone destruction, and the lung metastasis. These findings imply that such a cell sheet technology could be an appropriate approach to rapidly establish a sustainable orthotropic osteosarcoma model for tumor research and reduce mice consumption.
Complementarity of Digital Health and Peer Support: “This Is What’s Coming”
Authors: Tang Patrick Y. , Duni Janet , Peeples Malinda M. , Kowitt Sarah D. , Bhushan Nivedita L. , Sokol Rebeccah L. , Fisher Edwin B. 
Published: September 2021

PurposeThis study examined integration of peer support and a Food and Drug Administration-cleared, diabetes management app (DMA) in diabetes self-management support as a scalable model for those with type 2 diabetes mellitus (T2DM).MethodsTwo lay health Coaches delivered telephone-based self-management support to adults (N = 43) with T2DM recruited through a primary group practice. Those eligible were offered no-cost access to DMA for the entire 6-month study. Coaches introduced DMA and contacted individuals by phone and text with frequency dependent on participant needs/preferences. DMA supported monitoring of blood glucose, carbohydrate intake, and medication use, as well as messaging personalized to participants’ medication regimens. Clinical data were extracted from DMA, electronic medical records, and Coaches’ records. Structured interviews of 12 participants, 2 Coaches, and 5 project staff were analyzed using deductive pre-identified codes (regarding adoptability, patterns of use, value added, complementarity, and sustainability) utilizing standard procedures for qualitative analysis.ResultsOf the 43 participants, 38 (88.4%) enrolled in DMA. In general, participants used both DMA and lay health coaches, averaging 144.14 DMA entries (structured, e.g., medications, and free form, e.g., “ate at a restaurant” and “stressed”) and 5.86 coach contacts over the 6-month intervention. Correlation between DMA entries and coach contacts (r = .613, p &lt; 0.001) was consistent with complementarity as were participants’ and coaches’ observations that (a) DMA facilitated recognition of patterns and provided reminders and suggestions to achieve self-management plans, whereas (b) coaching provided motivation and addressed challenges that emerged. Mean hemoglobin A1c (A1c) declined from 9.93% to 8.86% (p &lt; 0.001), with no pattern of coaching or DMA use significantly related to reductions. Staff identified resources to coordinate coach/DMA interventions as a major sustainability challenge.ConclusionsDMA and peer support for diabetes management are compatible and complementary. Additional practice integration research is needed for adoption and scale-up.
Valve Abnormalities, Risk Factors for Heart Valve Disease and Valve Replacement Surgery in Spondyloarthritis. A Systematic Review of the Literature
Authors: Park Hye-Sang , Laiz Ana , Sanchez-Vega Jesus , Díaz del Campo Petra , Martín-Martínez Maria Auxiliadora , Guerra-Rodríguez Mercedes , Corominas Hector 
Published: September 2021

Objective: Evaluate the evidence on the abnormalities of the aortic root and heart valves, risk and prognostic factors for heart valve disease and valve replacement surgery in spondyloarthritis.Methods: A systematic literature review was performed using Medline, EMBASE and Cochrane databases until July 2021. Prevalence, incidence, risk and prognostic factors for heart valve disease; dimension, morphology, and pathological abnormalities of the valves were analyzed. Patient characteristics (younger age, history of cardiac disease or longer disease duration) and period of realization were considered for the analysis. The SIGN Approach was used for rating the quality of the evidence of the studies.Results: In total, 37 out of 555 studies were included. Overall, the level of evidence was low. The incidence of aortic insufficiency was 2.5–3.9‰. Hazard Ratio for aortic insufficiency was 1.8–2.0. Relative risk for aortic valve replacement surgery in ankylosing spondylitis patients was 1.22–1.46. Odds ratio for aortic insufficiency was 1.07 for age and 1.05 for disease duration. Mitral valve abnormalities described were mitral valve prolapse, calcification, and thickening. Aortic valve abnormalities described were calcification, thickening and an echocardiographic “subaortic bump.” Abnormalities of the aorta described were thickening of the wall and aortic root dilatation. The most common microscopic findings were scarring of the adventitia, lymphocytic infiltration, and intimal proliferation.Conclusions: A higher prevalence and risk of aortic valve disease is observed in patients with ankylosing spondylitis. Studies were heterogeneous and analysis was not adjusted by potential confounders. Most studies did not define accurate outcomes and may have detected small effects as being statistically significant.
Sex Differences in the Non-infarct-Related Artery-Based Quantitative Flow Ratio in Patients With ST-Elevation Myocardial Infarction: A Retrospective Study
Authors: Hou Hongli , Zhao Qi , Qu Chao , Sun Meng , Liu Qi , Huang Xingtao , Wang Xuedong , Zhang Ruoxi , Du Lifeng , Hou Jingbo , Yu Bo 
Published: September 2021

Introduction: It has been reported that sex has well-established relationships with the prevalence of coronary artery disease (CAD) and the major adverse cardiovascular events. Compared with men, the difference of coronary artery and myocardial characteristics in women has effects on anatomical and functional evaluations. Quantitative flow ratio (QFR) has been shown to be effective in assessing the hemodynamic relevance of lesions in stable coronary disease. However, its suitability in acute myocardial infarction patients is unknown. This study aimed to evaluate the sex differences in the non-infarct-related artery (NIRA)-based QFR in patients with ST-elevation myocardial infarction (STEMI).Methods: In this study, 353 patients with STEMI who underwent angiographic cQFR assessment and interventional therapy were included. According to contrast-flow QFR (cQFR) standard operating procedures: reliable software was used to modeling the hyperemic flow velocity derived from coronary angiography in the absence of pharmacologically induced hyperemia. 353 patients were divided into two groups according to sex. A cQFR ≤0.80 was considered hemodynamically significant, whereas invasive coronary angiography (ICA) luminal stenosis ≥50% was considered obstructive. Demographics, clinical data, NIRA-related anatomy, and functional cQFR values were recorded. Clinical outcomes included the NIRA reclassification rate between men and women, according to the ICA and cQFR assessments.Results: Women were older and had a higher body mass index (BMI) than men. The levels of diastolic blood pressure, troponin I, peak creatine kinase-MB, low-density lipoprotein cholesterol, N terminal pro B-type natriuretic peptide, stent diameter, and current smoking rate were found to be significantly lower in the female group than in the male group. Women had a lower likelihood of a positive cQFR ≤0.80 for the same degree of stenosis and a lower rate of NIRA revascularization. Independent predictors of positive cQFR included male sex and diameter stenosis (DS) &gt;70%.Conclusions: cQFR values differ between the sexes, as women have a higher cQFR value for the same degree of stenosis. The findings suggest that QFR variations by sex require specific interpretation, as these differences may affect therapeutic decision-making and clinical outcomes.
Degradation of Arable Soils in Central Yakutia: Negative Consequences of Global Warming for Yedoma Landscapes
Authors: Desyatkin Roman , Filippov Nikolai , Desyatkin Alexey , Konyushkov Dmitry , Goryachkin Sergey 
Published: September 2021

Global warming, which is especially intensive (up to 0.08°C yr−1) in permafrost area of Central Yakutia, has dramatic consequences for scarce arable land resources in this region. In Yedoma landscapes, intense permafrost thawing on arable fields unprotected by forest vegetation transforms the surface microtopography with the formation of residual thermokarst mounds (byllars) of 6–10 m in diameter surrounded by a polygonal network of hollows of 0.3–1.5 m in depth above melting ice wedges. This process also takes place on former croplands abandoned in the recent decades because of socioeconomic reasons. It is accompanied by a significant transformation of the previously highly likely homogeneous soil cover composed of Cambic Turbic Cryosols (Sodic) into differentiated complexes of permafrost-affected Stagnic Cambisols or Calcic Solonetzes (Turbic) on the mounds and Calcic Stagnic Solonetzes (Turbic) in the microlows. Surface soil horizons on the mounds have a strongly to very strongly alkaline reaction (pH 8.5–9.5) and low (&lt;2%) organic carbon content; a wavy line of effervescence is found at a depth of 15–30 cm. Soils in the microlows have a close to neutral reaction in the upper horizons (pH 6.2–7.5); higher organic carbon content (2–3%); more pronounced textural differentiation of the profile with the formation of typical natric Btn and, in some cases, overlying eluvial E horizons; deeper (50–60 cm) line of effervescence; and clear stagnic features in the lower part of the profile. In the case of shallow embedding by ice wedge, the lowermost part of the soil in the microlow is characterized by the low bulk density (1.04 g cm−3) because of the appearance of hollows after thawing of the ice-rich transient layer and melting of the top of ice wedges. This may be indicative of the further soil subsidence in the future and the appearance of initial thermokarst lakes (dyuedya) within the Yedoma terrain with its transformation into the alas type of landscape. Rapid thermokarst-driven development of microtopography followed by differentiation of the soil cover with increasing soil alkalinity on the microhighs and soil textural differentiation and overmoistening of deep layers in the microlows prevents the return of abandoned arable land to agriculture in Yedoma landscapes.
Exploring Formative Assessment and Co-Regulation in Kindergarten Through Interviews and Direct Observation
Authors: Braund Heather , DeLuca Christopher , Panadero Ernesto , Cheng Liying 
Published: September 2021

Formative assessment practices have been theoretically connected to the development of self-regulation with mounting empirical evidence. Co-regulation is the process whereby a more capable individual (e.g., teacher or peer) attunes the behaviours, emotions, or cognitive processes of an individual (a student) to align with goals or expectations and is being recognized as a strategy for developing self-regulation. Formative assessment practices may facilitate co-regulation, however, much of the literature has focused on older student populations. This phenomenological study explored the relationship between formative assessment and co-regulation in eight Kindergarten classrooms. Eight Kindergarten teachers and four Early Childhood Educators (ECE) completed semi-structured interviews in 2019 during two time periods with each participant completing two interviews. To supplement the interviews, 56 h of classroom observations were completed in each classroom, totaling 448 h of observations across eight classrooms. Interviews were audio-recorded and transcribed verbatim. Qualitative data were analyzed thematically. Four themes emerged: 1) Authentic assessment and self-regulation practices, 2) Feedback as foundational, 3) Formative assessment and co-regulation have shared purposes, and 4) Connections between classroom assessment and co-regulation. Participants described their classroom assessment and self-regulation practices as authentic and natural for students while also providing examples of their interactions with students as a form of co-regulation. Feedback was articulated as foundational to both classroom assessment and co-regulation. Participants illustrated examples of feedback from peers (including through modified peer-assessment). Shared purposes between formative assessment and co-regulation placed students at the centre of the learning process, encouraging agentic behaviours, and scaffolding student thinking. The final theme underlined the need to broaden conceptualizations of assessment in Kindergarten. Findings suggested student agency as the bridge between classroom assessment and co-regulation, and a bidirectional, mutually supportive, relationship between formative assessment and co-regulation.
MAPbI3 Deposition by LV-PSE on TiO2 for Photovoltaic Application
Authors: Smecca Emanuele , Jena Ajay Kumar , Deretzis Ioannis , Valastro Salvatore , Sanzaro Salvatore , Mannino Giovanni , Bongiorno Corrado , La Magna Antonino , Miyasaka Tsutomu , Alberti Alessandra 
Published: September 2021

Hybrid perovskites are one of the most popular materials nowadays due to their very exclusive properties. To mitigate costs, complexity, and environmental impact, in this work, we have prepared methylammonium lead iodide (MAPbI3) films by a two-step Low-Vacuum Proximity-Space-Effusion (LV-PSE). The LV-PSE method exploits the low vacuum and the short diffusion path from the precursor source to have high thermal energy and partial pressure of the sublimated species close to the substrate. To this aim, the substrate is located at a medium distance (∼2 cm) from the melting pots in a low-vacuum chamber at ∼4 × 10−2 mbar. In the first step, a PbI2 film is deposited on a substrate; in the second step, the conversion into MAPbI3 occurs via an adsorption-incorporation-migration mechanism through the evaporation of methylammonium iodide (MAI) reagents. To exploit the potential of the conversion reaction, 190 nm MAPbI3 layers are deposited on TiO2 substrates. The layers were characterized in terms of crystal structure by X-ray diffraction (XRD) analyses, which showed the exclusive presence of MAPbI3 confirming the complete conversion of the PbI2 film. Scanning Electron Microscopy (SEM) analyses revealed a flat uniform pinhole-free coverage of the substrates and good conformational coverage of the TiO2 underlayer. Transmission Electron Microscopy (TEM) analyses addressed the formation of the tetragonal phase and the absence of the amorphous phase in the film. Spectroscopic ellipsometry (SE) analyses were used to explore the optical properties and the stability of the MAPbI3 layer at different temperatures and ambient conditions. As proof of concept, solar cell architectures were prepared using TiO2 as Electron Transporting Layer (ETL), Spiro-OMeTAD as Hole Transporting Layer (HTL), and Au as a contact to exploit the new up-scalable and clean deposition method. Using just ∼190 nm thick layers, the best efficiency reached with this architecture was 6.30%.
The Optimal Time of Ovarian Reserve Recovery After Laparoscopic Unilateral Ovarian Non-Endometriotic Cystectomy
Authors: Li Huaping , Yan Bin , Wang Yanli , Shu Zhiming , Li Ping , Liu Yahong , Wang Ying , Ni Xiaohong , Liu Zhou 
Published: September 2021

BackgroundLaparoscopic ovarian cystectomy is established as the standard surgical approach for the treatment of benign ovarian cysts. However, previous studies have shown that potential fertility can be directly impaired by laparoscopic ovarian cystectomy, diminished ovarian reserve (DOR), and even premature ovarian failure. Therefore, fertility-preserving interventions are required for benign gynecologic diseases. However, there are still little data on the time period required for recovery of ovarian reserve after the laparoscopic unilateral ovarian cystectomy, which is very important for the individualization of treatment protocols. This study aimed at investigating the time needed for the ovarian reserve to recover after laparoscopic unilateral ovarian non-endometriotic cystectomy.Materials and MethodsSixty-seven patients with unilateral ovarian non-endometriotic cyst from Zhoupu and Punan Hospitals who underwent laparoscopic unilateral ovarian cystectomy were recruited as a postoperative observation group (POG). Also, 69 healthy age-matched women without ovarian cyst who did not undergo surgery were recruited as a referent group (RFG). Ovarian reserve with the serum anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), estradiol (E2) levels, ovarian arterial resistance index (OARI), and antral follicle counts (AFCs) were measured on the third to fifth days of the same menstrual cycle. A postoperative 6-month follow-up of cases was performed.ResultsCompared with RFG, AFC of cyst side in the POG group showed no difference in the first, third, and sixth postoperative month (F = 0.03, F = 0.02, F = 0.55, respectively; p = 0.873, p = 0.878, p = 0.460, respectively). The OARI of cyst side in the POG group revealed no differences in the first, third, and sixth postoperative month (F = 0.73, F = 3.57, F = 1.75, respectively; p = 0.395, p = 0.061, p = 0.701, respectively). In the first month, the postoperative AMH levels significantly declined, reaching 1.88 ng/ml [interquartile range (IQR): 1.61–2.16 ng/ml] in POG and 2.57 ng/ml (IQR: 2.32–2.83 ng/ml) in RFG (F = 13.43, p = 0.000). For the data of AMH levels stratified by age, the same trend was observed between less than 25 and more than 26 years old. At this same time interval, the postoperative rate of decline was significantly lower compared to the preoperative one in POG (32.75%). The same trend was observed between the POG and RFG groups (26.67%).ConclusionsThe optimal time for recovery of ovarian reserve after laparoscopic unilateral ovarian cystectomy is estimated to be 6 months.