bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of Zn-doped synthetic polymer materials on bone regeneration: a systematic review
Authors: Wang Siyi , Li Rong , Xia Dandan , Zhao Xiao , Zhu Yuan , Gu Ranli , Yoon Jungmin , Liu Yunsong 
Published: February 2021

AbstractIntroductionTo repair bone defects, a variety of bone substitution materials have been used, such as ceramics, metals, natural and synthetic polymers, and combinations thereof. In recent decades, a wide range of synthetic polymers have been used for bone regeneration. These polymers have the advantages of biocompatibility, biodegradability, good mechanical properties, low toxicity, and ease of processing. However, when used alone, they are unable to achieve ideal bone formation. Incorporating zinc (Zn) into synthetic polymers has been considered, as previous studies have shown that Zn2+promotes stem cell osteogenesis and mineral deposition. The purpose of this systematic review was to provide an overview of the application and effectiveness of Zn in synthetic polymers for bone regeneration, whether used alone or in combination with other biomaterials. This study was performed according to the PRISMA guidelines.Materials and methodsA search of the PubMed, Embase, and the Cochrane Library databases for articles published up to June 2020 revealed 153 relevant studies. After screening the titles, abstracts, and full texts, 13 articles were included in the review; 9 of these were in vitro, 3 were in vivo, and 1 included both in vitro and in vivo experiments.ResultsAt low concentrations, Zn2+promoted cell proliferation and osteogenic differentiation, while high-dose Zn2+resulted in cytotoxicity and inhibition of osteogenic differentiation. Additionally, one study showed that Zn2+reduced apatite formation in simulated body fluid. In all of the in vivo experiments, Zn-containing materials enhanced bone formation.ConclusionsAt appropriate concentrations, Zn-doped synthetic polymer materials are better able to promote bone regeneration than materials without Zn.
The kernel-weighted local polynomial regression (KwLPR) approach: an efficient, novel tool for development of QSAR/QSAAR toxicity extrapolation models
Authors: Gajewicz-Skretna Agnieszka , Kar Supratik , Piotrowska Magdalena , Leszczynski Jerzy 
Published: February 2021

AbstractThe ability of accurate predictions of biological response (biological activity/property/toxicity) of a given chemical makes the quantitative structure‐activity/property/toxicity relationship (QSAR/QSPR/QSTR) models unique among the in silico tools. In addition, experimental data of selected species can also be used as an independent variable along with other structural as well as physicochemical variables to predict the response for different species formulating quantitative activity–activity relationship (QAAR)/quantitative structure–activity–activity relationship (QSAAR) approach. Irrespective of the models' type, the developed model's quality, and reliability need to be checked through multiple classical stringent validation metrics. Among the validation metrics, error-based metrics are more significant as the basic idea of a good predictive model is to improve the predictions' quality by lowering the predicted residuals for new query compounds. Following the concept, we have checked the predictive quality of the QSAR and QSAAR models employing kernel-weighted local polynomial regression (KwLPR) approach over the traditional linear and non-linear regression-based approaches tools such as multiple linear regression (MLR) andknearest neighbors (kNN). Five datasets which were previously modeled using linear and non-linear regression method were considered to implement the KwPLR approach, followed by comparison of their validation metrics outcomes. For all five cases, the KwLPR based models reported better results over the traditional approaches. The present study's focus is not to develop a better or improved QSAR/QSAAR model over the previous ones, but to demonstrate the advantage, prediction power, and reliability of the KwLPR algorithm and establishing it as a novel, powerful cheminformatic tool. To facilitate the use of the KwLPR algorithm for QSAR/QSPR/QSTR/QSAAR modeling, the authors provide an in-house developedKwLPR.RMDscript under the open-sourceRprogramming language.
Steganography algorithm based on modified EMD-coded PU partition modes for HEVC videos
Authors: Zhang Zhenzhen , Li Zhaohong , Liu Jindou , Yan Huanma , Yu Lifang 
Published: February 2021

AbstractAs High Efficiency Video Coding (HEVC) is a worldwide popular video coding standard, the steganography of HEVC videos has gained more and more attention. Prediction unit (PU) is one of the most important innovative modules of HEVC; thus, PU partition mode-based steganography is becoming a novel branch of HEVC steganography. However, the embedding capacity of this kind of steganography is limited by the types of PU partition modes. To solve the problem, modified exploiting modification direction (EMD)-coded PU partition mode-based steganography is proposed in this paper, which can hide a secret digit in a (2n + x − 1)-ary notational system in a pair of PU partition modes and thus enlarging the capacity. Furthermore, two mapping patterns for PU partition modes are analyzed, and the one that performs the better is selected as the final mapping pattern. Firstly, 8 × 8- and 16 × 16-sized PU partition modes are recorded according to the optimal mapping pattern in the video encoding process. Then, PU partition modes are modified by using the proposed method to satisfy the requirement of secret information. Finally, the stego video can be obtained by re-encoding the video with the modified PU partition modes. Experimental results show that the embedding capacity can be significantly enlarged, and compared with the state-of-the-art work, the proposed method has much larger capacity while keeping high visual quality.
Pentixafor PET/CT for imaging of chemokine receptor 4 expression in esophageal cancer – a first clinical approach
Authors: Linde Philipp , Baues Christian , Wegen Simone , Trommer Maike , Quaas Alexander , Rosenbrock Johannes , Celik Eren , Marnitz Simone , Bruns Christiane J. , Fischer Thomas , Schomaecker Klaus , Wester Hans-Juergen , Drzezga Alexander , van Heek Lutz , Kobe Carsten 
Published: February 2021

Abstract
Background
Expression of CXCR4, a chemokine (C-X-C motif) receptor that plays a central role in tumor growth and metastasis of circulating tumor cells, has been described in a variety of solid tumors. A high expression of CXCR4 has a prognostic significance with regard to overall and progression-free survival and offers a starting point for targeted therapies. In this context, [68]Ga-Pentixafor-Positron Emission Tomography/Computer Tomography (PET/CT) offers promising possibility of imaging the CXCR4 expression profile. We set out to compare a [18F] fluorodeoxyglucose (FDG)-PET/CT and a [68Ga]Pentixafor-PET/CT in (re-)staging and radiation planning of patients with localized esophageal cancer.

Materials and methods
In this retrospective analysis, ten patients, with adeno- or squamous cell carcinoma of the esophagus (n = 3 and n = 7, respectively), which were scheduled for radio (chemo) therapy, were imaged using both Pentixafor and FDG PET/CT examinations. All lesions were visually rated as Pentixafor and FDG positive or negative. For both tracers, SUVmax was measured all lesions and compared to background. Additionally, immunohistochemistry of CXCR4 was obtained in patients undergoing surgery.

Results
FDG-positive tumor-suspicious lesions were detected in all patients and a total of 26 lesions were counted. The lesion-based analysis brought equal status in 14 lesions which were positive for both tracers while five lesions were FDG positive and Pentixafor negative and seven lesions were FDG negative, but Pentixafor positive. Histopathologic correlation was available in seven patients. The CXCR4 expression of four non-pretreated tumour lesion samples was confirmed immunohistochemically.

Conclusion
Our data shows that additional PET/CT imaging with Pentixafor for imaging the CXCR4 chemokine receptor is feasible but heterogeneous in both newly diagnosed and pretreated recurrent esophageal cancer. In addition, the Pentixafor PET/CT may serve as complementary tool for radiation field expansion in radiooncology.
“Stewards of the future: accompanying the rising tide of young voices by setting youth-inclusive research agendas in sustainability research”
Authors: Barraclough Alicia Donnellan , Sakiyama Melina , Schultz Lisen , Måren Inger Elisabeth 
Published: February 2021

Abstract
Background
From the worldwide youth-led climate strikes of 2018–2019 to the student-initiated austerity protests in Chile in 2019, it is undeniable that young people have been protagonists in pressuring for social change towards greater sustainability in recent years. This piece reflects on youth as agents of social-ecological change, and what researchers can learn from the rise in youth-led social movements demanding action in the face of global sustainability challenges.
The study of sustainability problems like climate change and biodiversity loss, intrinsically requires consideration of inter-generational equity. However, despite 50% of the global population being under 30 years old, youth are often not included explicitly as actors in environmental social sciences and sustainability-related research. Here we discuss why explicitly considering young people as distinct actors during the research process is important, as it allows researchers to engage in just and inclusive work whilst at the same time accounting for important agents of change in complex social-ecological systems.

Results
As a framework for our inquiry we present the themes which emerged during a series of international meetings and forums on sustainability challenges and youth in 2019, a year characterized by world-wide youth mobilization. Our briefing spans the United Nations Youth 2019 Climate Action Summit, the post-2020 meetings organized by the youth branch of the Convention of Biological Diversity (CBD), the UNESCO Man and Biosphere Youth forums and the results from the Global Shapers Survey of the World Economic Forum.

Conclusions
We argue that if researchers wish to facilitate youth-inclusive evidence-based decision making, research agendas must address knowledge gaps highlighted by institutional efforts to incorporate youth concerns within global sustainability policy, a recommendation that is even more relevant in the light of the COVID-19 crisis. We draw on the themes which emerged in our analysis of international youth meetings to provide recommendations for research agendas which account both for young actors as both passive and active components of social-ecological change and we propose a more inclusive and holistic study of coupled natural-human systems.
Psychotropic Drugs in Patients with Cushing’s Disease Before Diagnosis and at Long-Term Follow-Up: A Nationwide Study
Authors: Bengtsson Daniel , Ragnarsson Oskar , Berinder Katarina , Dahlqvist Per , Edén Engström Britt , Ekman Bertil , Höybye Charlotte , Burman Pia , Wahlberg Jeanette 
Published: February 2021

Abstract

Context
Psychiatric symptoms are common in Cushing’s disease (CD) and seem only partly reversible following treatment.

Objective
To investigate drug dispenses associated to psychiatric morbidity in CD patients before treatment and during long-term follow-up.

Design
Nationwide longitudinal register-based study.

Setting
University Hospitals in Sweden.

Subjects
CD patients diagnosed between 1990 and 2018 (N = 372) were identified in the Swedish Pituitary Register. Longitudinal data was collected from 5 years before, at diagnosis, and during follow-up. Four matched controls per patient were included. Cross-sectional subgroup analysis of 76 patients in sustained remission was also performed.

Main outcome measures
Data from the Swedish Prescribed Drug Register and the Patient Register.

Results
In the 5-year period before and at diagnosis, use of antidepressants (odds ratio [OR] 2.2 [95% confidence interval (CI) 1.3-3.7]) and 2.3 [1.6-3.5]), anxiolytics [2.9 (1.6-5.3) and 3.9 (2.3-6.6)], and sleeping pills [2.1 (1.2-3.7) and 3.8 (2.4-5.9)] was more common in CD than controls. ORs remained elevated at 5-year follow-up for antidepressants [2.4 (1.5-3.9)] and sleeping pills [3.1 (1.9-5.3)]. Proportions of CD patients using antidepressants (26%) and sleeping pills (22%) were unchanged at diagnosis and 5-year follow-up, whereas drugs for hypertension and diabetes decreased. Patients in sustained remission for median 9.3 years (interquartile range 8.1-10.4) had higher use of antidepressants [OR 2.0 (1.1-3.8)] and sleeping pills [2.4 (1.3-4.7)], but not of drugs for hypertension.

Conclusions
Increased use of psychotropic drugs in CD was observed before diagnosis and remained elevated regardless of remission status, suggesting persisting negative effects on mental health. The study highlights the importance of early diagnosis of CD, and the need for long-term monitoring of mental health.
Regulation of Cell Types Within Testicular Organoids
Authors: Lara Nathalia de Lima e Martins , Sakib Sadman , Dobrinski Ina 
Published: February 2021

Abstract
Organoids are 3-dimensional (3D) structures grown in vitro that emulate the cytoarchitecture and functions of true organs. Therefore, testicular organoids arise as an important model for research on male reproductive biology. These organoids can be generated from different sources of testicular cells, but most studies to date have used immature primary cells for this purpose. The complexity of the mammalian testicular cytoarchitecture and regulation poses a challenge for working with testicular organoids, because, ideally, these 3D models should mimic the organization observed in vivo. In this review, we explore the characteristics of the most important cell types present in the testicular organoid models reported to date and discuss how different factors influence the regulation of these cells inside the organoids and their outcomes. Factors such as the developmental or maturational stage of the Sertoli cells, for example, influence organoid generation and structure, which affect the use of these 3D models for research. Spermatogonial stem cells have been a focus recently, especially in regard to male fertility preservation. The regulation of the spermatogonial stem cell niche inside testicular organoids is discussed in the present review, as this research area may be positively affected by recent progress in organoid generation and tissue engineering. Therefore, the testicular organoid approach is a very promising model for male reproductive biology research, but more studies and improvements are necessary to achieve its full potential.
Total Thyroidectomy Versus Lobectomy for Thyroid Cancer: Single-Center Data and Literature Review
Authors: Colombo Carla , De Leo Simone , Di Stefano Marta , Trevisan Matteo , Moneta Claudia , Vicentini Leonardo , Fugazzola Laura 
Published: February 2021

Abstract
Background
Controversies remain about the ideal risk-based surgical approach for differentiated thyroid cancer (DTC).

Methods
At a single tertiary care institution, 370 consecutive patients with low- or intermediate-risk DTC were submitted to either lobectomy (LT) or total thyroidectomy (TT) and were followed up.

Results
Event-free survival by Kaplan–Meier curves was significantly higher after TT than after LT for the patients with either low-risk (P = 0.004) or intermediate-risk (P = 0.032) tumors. At the last follow-up visit, the prevalence of event-free patients was higher in the TT group than in the LT low-risk group (95% and 87.5%, respectively; P = 0.067) or intermediate-risk group (89% and 50%; P = 0.008). No differences in persistence prevalence were found among microcarcinomas treated by LT or TT (low risk, P = 0.938 vs. intermediate-risk, P = 0.553). Nevertheless, 15% of the low-risk and 50% of the intermediate-risk microcarcinomas treated by LT were submitted to additional treatments. On the other hand, macrocarcinomas were significantly more persistent if treated with LT than with TT (low-risk, P = 0.036 vs. intermediate-risk, P = 0.004). Permanent hypoparathyroidism was more frequent after TT (P = 0.01). After LT, thyroglobulin (Tg)/thyroid-stimulating hormone (TSH) had shown decreasing trend in 68% of the event-free patients and an increasing trend in the persistent cases.

Conclusions
Lobectomy can be proposed for low-risk microcarcinomas, although in a minority of cases, additional treatments are needed, and a longer follow-up period usually is required to confirm an event-free outcome compared with that for patients treated with TT. On the other hand, to achieve an excellent response, TT should be favored for intermediate-risk micro- and macro-DTCs despite the higher frequency of postsurgical complications.
Unifying Online and Offline Preference for Social Link Prediction
Authors: Zhou Fan , Zhang Kunpeng , Wu Bangying , Yang Yi , Wang Harry Jiannan 
Published: February 2021

Recent advances in network representation learning have enabled significant improvement in the link prediction task, which is at the core of many downstream applications. As an increasing amount of mobility data become available because of the development of location-based technologies, we argue that this resourceful mobility data can be used to improve link prediction tasks. In this paper, we propose a novel link prediction framework that utilizes user offline check-in behavior combined with user online social relations. We model user offline location preference via a probabilistic factor model and represent user social relations using neural network representation learning. To capture the interrelationship of these two sources, we develop an anchor link method to align these two different user latent representations. Furthermore, we employ locality-sensitive hashing to project the aggregated user representation into a binary matrix, which not only preserves the data structure but also improves the efficiency of convolutional network learning. By comparing with several baseline methods that solely rely on social networks or mobility data, we show that our unified approach significantly improves the link prediction performance.Summary of Contribution: This paper proposes a novel framework that utilizes both user offline and online behavior for social link prediction by developing several machine learning algorithms, such as probabilistic factor model, neural network embedding, anchor link model, and locality-sensitive hashing. The scope and mission has the following aspects: (1) We develop a data and knowledge modeling approach that demonstrates significant performance improvement. (2) Our method can efficiently manage large-scale data. (3) We conduct rigorous experiments on real-world data sets and empirically show the effectiveness and the efficiency of our proposed method. Overall, our paper can contribute to the advancement of social link prediction, which can spur many downstream applications in information systems and computer science.
Top Management Team Power in China: Measurement and Validation
Authors: Ke Bin , Mao Xinshu , Wang Bin , Zuo Luo 
Published: February 2021

We propose and validate a comprehensive measure of power for the top management teams (TMTs) of publicly listed Chinese firms. We show that our measure is positively associated with the four power dimensions developed by prior research for U.S. firms as well as three Asia-relevant power dimensions, including political capital, seniority, and gender. We find that our TMT power measure is a valid proxy for TMT power for both state-controlled firms and non-state-controlled firms. We also compare our TMT power measure with one alternative TMT power proxy based on executive compensation and find no evidence that the alternative proxy is better than our measure in capturing TMT’s true power. Further, we provide evidence that the divergence between our power proxy and the power proxy based on executive compensation reflects nonmarket institutional forces in China and has important implications for corporate outcomes. This paper was accepted by Brian Bushee, accounting.
Is Charitable Giving a Zero-Sum Game? The Effect of Competition Between Charities on Giving Behavior
Authors: Schmitz Jan 
Published: February 2021

The competition for donations between charities is tough. Yet, little is known about how giving behavior is affected by competition between charities. Do people have a need to satisfy their demand for giving by contributing to a particular charity? Or can the demand for doing good be satisfied by giving to any organization? In a donation dictator game, I vary competition between charities by (i) altering the set of similar real charities to which subjects can donate and (ii) changing the relative price of giving to a randomly selected charity in the choice set by introducing a matching grant. I find weak substitution between charities when giving to more than one charity is possible, as the donated amounts to individual charities decrease with the size of the choice set. At the same time, aggregate giving to all charities increases when charities are in competition. Intensified competition through an increase in the charitable giving market seems to attract new giving and increases overall public good provision. Price competition, however, does not attract new donations when market size is constant and charities compete for donations. These findings carry important insights for managers of nonprofit organizations and provide information on how to improve existing fundraising strategies.This paper was accepted by Yan Chen, decision analysis.
Molecular epidemiology and carbapenem resistance of Pseudomonas aeruginosa isolated from patients with burns
Authors: Khalili Younes , Memar Mohammad Yousef , Farajnia Safar , Adibkia Khosro , Kafil Hossein Samadi , Ghotaslou Reza 
Published: February 2021

Objective: The aim of this study was to investigate the molecular epidemiology and carbapenem resistance mechanisms of Pseudomonas aeruginosa isolated from patients with burns in Azerbaijan, Iran. Method: Pseudomonas aeruginosa was isolated from 38 patients with burns. Disk diffusion and agar dilution methods were used to determine antibiotic susceptibility patterns. The overproduction of AmpC β-lactamase and efflux pumps were detected by phenotypic methods. The presence of carbapenemase-encoding genes was detected by multiplex polymerase chain reaction (PCR). Expression of the OprD gene and MexAB efflux pumps were also evaluated with real-time PCR. Random amplified polymorphic DNA typing (RAPD-PCR) was used for genotyping of carbapenem-resistant Pseudomonas aeruginosa (CRPA). Results: Minimum inhibitory concentration (MIC) assays demonstrated high levels of resistance to all classes of antibiotics except colistin and polymyxin B. The initial screening by carbapenem disks indicated 24 isolates (63.15%) as CRPA. Different mechanisms of carbapenem resistance were observed, including carbapenemase production (8.4%), overexpression of AmpC (25%) and decreased expression of OprD (75%). The overexpression of MexAB efflux pumps was detected in 19 (79.1%) isolates by phenotypic assay or real-time PCR. The resistance to carbapenem was multifactorial in most cases (58.3%). The RAPD genotyping revealed different patterns with nine clusters. Conclusion: According to our results, the prevalence of CRPA is at an alarming level. Our results did not demonstrate an epidemic clone. The most common mechanism of carbapenem resistance was decreased expression of OprD. Therefore, we suggest a reconsideration in the management of CRPA infections of patients in our burn care hospital in Azerbaijan, Iran.