bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rock Size‐Frequency Distributions at the InSight Landing Site, Mars
Authors: Golombek M. P. , Trussell A. , Williams N. , Charalambous C. , Abarca H. , Warner N. H. , Deahn M. , Trautman M. , Crocco R. , Grant J. A. , Hauber E. , Deen R. 
Published: November 2021

AbstractRocks around the InSight lander were measured in lander orthoimages of the near field (<10 m), in panoramas of the far field (<40 m), and in a high‐resolution orbital image around the lander (1 km2). The cumulative fractional area versus diameter size‐frequency distributions for four areas in the near field fall on exponential model curves used for estimating hazards for landing spacecraft. The rock abundance varies in the near field from 0.6% for the sand and pebble‐rich area to the east within Homestead hollow to ∼3–5% for the progressively rockier areas to the south, north, and west. The rock abundance of the entire near field is just over 3%, which falls between that at the Phoenix (2%) and Spirit (5%) landing sites. Rocks in the far field (<40 m) that could be identified in both the surface panorama and a high‐resolution orbital image fall on the same exponential model curve as the average near‐field rocks. Rocks measured in a high‐resolution orbital image (27.5 cm/pixel) within ∼500 m of the lander that includes several rocky ejecta craters fall on 4–5% exponential model curves, similar to the northern and western near‐field areas. As a result, the rock abundances observed from orbit fall on the same exponential model rock abundance curves as those viewed from the surface. These rock abundance measurements around the lander are consistent with thermal imaging estimates over larger pixel areas as well as expectations from fragmentation theory of an impacted Amazonian/Hesperian lava flow.
The Pamir Frontal Thrust Fault: Holocene Full‐Segment Ruptures and Implications for Complex Segment Interactions in a Continental Collision Zone
Authors: Patyniak M. , Landgraf A. , Dzhumabaeva A. , Baikulov S. , Williams A. M. , Weiss J.R. , Hilley G. E. , Preusser F. , Abdrakhmatov K. E. , Arrowsmith R. J , Strecker M. R. 
Published: November 2021

AbstractThe Pamir Frontal Thrust (PFT) of the Trans‐Alai Range in Central Asia is the principal active fault of the intracontinental convergence zone between the Pamir and Tien Shan. Its northward propagation is reflected by frequent seismic activity and ongoing crustal shortening. Recent and historic earthquakes exhibit complex rupture patterns within and across seismotectonic segments bounding the Trans Alai, challenging our understanding of fault interaction and seismogenic potential. We provide paleoseismic data from five trenches along the central PFT segment (cPFT) and interpret five and possibly six paleoearthquakes that have ruptured since ∼7 ka and 16 ka, respectively. Our results indicate that at least three major earthquakes ruptured the full‐segment length and possibly crossed segment boundaries with a recurrence interval of ∼1.9 kyr and potential magnitudes of up to Mw 7.4. We did not find evidence for great (i.e., Mw ≥8) earthquakes. However, discrepancies between slip and rupture extent during apparent partial segment ruptures in the western half of the cPFT, combined with significantly higher scarp offsets, indicate a more mature fault section with potential for future fault linkage. We estimate an average rate of horizontal motion for the cPFT of 4.1 ± 1.5 mm/yr during the past ∼5 kyr, which does not fully match the GNSS‐derived present‐day shortening rate of ∼10 mm/yr. This suggests a complex distribution of strain accumulation and potential slip partitioning between the cPFT and additional faults and folds within the Pamir that may be associated with a partially locked regional décollement.
High‐Spatial‐Resolution Mass Rates From GRACE and GRACE‐FO: Global and Ice Sheet Analyses
Authors: Loomis Bryant D. , Felikson Denis , Sabaka Terence J. , Medley Brooke 
Published: November 2021

AbstractGRACE and GRACE‐FO gravimetry data are unique in its ability to observe global water mass variability and has frequently been applied for the determination of global mass rates to quantify the impacts of climate change and human activity on global freshwater availability and land ice evolution. However, its relatively coarse spatial resolution of ∼300‐500 km at monthly intervals precludes its direct use to measure mass changes in smaller drainage basins and individual glacier systems. We present a new global high‐resolution mascon product that improves spatial resolution and signal recovery by estimating trends directly from more than 16 years of Level 1B GRACE and GRACE‐FO data. We compare this product to independent gravimetry spherical harmonic trend estimates and to ice sheet mass rates derived from ICESat and ICESat‐2 laser altimetry. We demonstrate enhanced global signal recovery and improved agreement with ICESat/ICESat‐2 and discuss likely causes for the remaining discrepancies between the gravimetry and laser altimetry solutions.
Joint Estimation of Balanced Motions and Internal Tides From Future Wide‐Swath Altimetry
Authors: Le Guillou Florian , Lahaye Noé , Ubelmann Clément , Metref Sammy , Cosme Emmanuel , Ponte Aurélien , Le Sommer Julien , Blayo Eric , Vidard Arthur 
Published: November 2021

AbstractWide‐swath altimetry, for example, the Surface Water and Ocean Topography mission is expected to provide Sea Surface Height (SSH) measurements resolving scales of a few tens of kilometers. Over a large fraction of the globe, the SSH signal at these scales is essentially a superposition of a component due to balanced motions (BMs) and another component due to internal tides (ITs). Several oceanographic applications require the separation of these components and their mapping on regular grids. For that purpose, the paper introduces an alternating minimization algorithm that iteratively implements two data assimilation techniques, each specific to the mapping of one component: a quasi‐geostrophic model with Back‐and‐Forth Nudging for BMs, and a linear shallow‐water model with 4‐Dimensional Variational assimilation for ITs. The algorithm is tested with Observation System Simulation Experiments where the truth is provided by a primitive‐equation ocean model in an idealized configuration simulating a turbulent jet and mode‐one ITs. The algorithm reconstructs almost 80% of the variance of BMs and ITs, the remaining 20% being mostly due to dynamics that cannot be described by the simple models used. Importantly, in addition to the reconstruction of stationary ITs, the amplitude and phase of nonstationary ITs are reconstructed. Sensitivity experiments show that the quality of reconstruction significantly depends upon the timing of observations. Although idealized, this study represents a step forward towards the disentanglement of BMs and ITs signals from real wide‐swath altimetry data.
Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression
Authors: Xue Chen , Li Ganglei , Lu Juan , Li Lanjuan 
Published: November 2021

AbstractCircular RNAs (circRNAs), covalently closed noncoding RNAs, are widely expressed in eukaryotes and viruses. They can function by regulating target gene expression, linear RNA transcription and protein generation. The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays key roles in many biological and cellular processes, such as cell proliferation, growth, invasion, migration, and angiogenesis. It also plays a pivotal role in cancer progression. Emerging data suggest that the circRNA/PI3K/AKT axis modulates the expression of cancer-associated genes and thus regulates tumor progression. Aberrant regulation of the expression of circRNAs in the circRNA/PI3K/AKT axis is significantly associated with clinicopathological characteristics and plays an important role in the regulation of biological functions. In this review, we summarized the expression and biological functions of PI3K-AKT-related circRNAs in vitro and in vivo and assessed their associations with clinicopathological characteristics. We also further discussed the important role of circRNAs in the diagnosis, prognostication, and treatment of cancers.
Transcriptional responses of Trichodesmium to natural inverse gradients of Fe and P availability
Authors: Cerdan-Garcia E , Baylay A , Polyviou D , Woodward E M S , Wrightson L , Mahaffey C , Lohan M C , Moore C M , Bibby T S , Robidart J C 
Published: November 2021

Abstract
The filamentous diazotrophic cyanobacterium Trichodesmium is responsible for a significant fraction of marine di-nitrogen (N2) fixation. Growth and distribution of Trichodesmium and other diazotrophs in the vast oligotrophic subtropical gyres is influenced by iron (Fe) and phosphorus (P) availability, while reciprocally influencing the biogeochemistry of these nutrients. Here we use observations across natural inverse gradients in Fe and P in the North Atlantic subtropical gyre (NASG) to demonstrate how Trichodesmium acclimates in situ to resource availability. Transcriptomic analysis identified progressive upregulation of known iron-stress biomarker genes with decreasing Fe availability, and progressive upregulation of genes involved in the acquisition of diverse P sources with decreasing P availability, while genes involved in N2 fixation were upregulated at the intersection under moderate Fe and P availability. Enhanced N2 fixation within the Fe and P co-stressed transition region was also associated with a distinct, consistent metabolic profile, including the expression of alternative photosynthetic pathways that potentially facilitate ATP generation required for N2 fixation with reduced net oxygen production. The observed response of Trichodesmium to availability of both Fe and P supports suggestions that these biogeochemically significant organisms employ unique molecular, and thus physiological responses as adaptations to specifically exploit the Fe and P co-limited niche they construct.
Pseudogene RPL32P3 regulates the blood–tumor barrier permeability via the YBX2/HNF4G axis
Authors: Ding Ye , Liu Xiaobai , Yang Chunqing , Ruan Xuelei , Wang Di , Liu Yunhui , Shang Xiuli , Liu Qianshuo , Shen Shuyuan , Zhu Lu , Xue Yixue 
Published: November 2021

AbstractThe existence of the blood–tumor barrier (BTB) severely hinders the transport of anti-tumor drugs to brain tumor tissues. Selectively opening BTB is of great significance to improve the chemotherapy effect of glioma. Pseudogenes have been recognized as important regulators in various biologic processes. In this study, we identified that ribosomal protein L32 pseudogene 3 (RPL32P3) was highly expressed in glioma-exposed endothelial cells (GECs). Knockdown of RPL32P3 decreased the expression of tight junction-related proteins (TJPs) and increased BTB permeability. Subsequent analysis of the underlying mechanism indicated that RPL32P3 recruited lysine methyltransferase 2 A (KMT2A) to the Y-box binding protein 2 (YBX2) promoter region and mediated H3K4me3 to promote YBX2 transcription. Highly expressed YBX2 bound and stabilized hepatocyte nuclear factor 4 gamma (HNF4G) mRNA. Highly expressed HNF4G directly bound to the promoters of TJPs ZO-1, occludin and claudin-5 to promote their transcriptional activities and regulated BTB permeability. The simultaneous knockdown of RPL32P3, YBX2, and HNF4G combined with doxorubicin (DOX) increased the apoptosis of glioma cells. In conclusion, the current study indicated that RPL32P3 knockdown increased BTB permeability through the YBX2/HNF4G pathway. These findings may provide new targets for the comprehensive treatment of glioma.
Dynamic transition of current-driven single-skyrmion motion in a room-temperature chiral-lattice magnet
Authors: Peng Licong , Karube Kosuke , Taguchi Yasujiro , Nagaosa Naoto , Tokura Yoshinori , Yu Xiuzhen 
Published: November 2021

AbstractDriving and controlling single-skyrmion motion promises skyrmion-based spintronic applications. Recently progress has been made in moving skyrmionic bubbles in thin-film heterostructures and low-temperature chiral skyrmions in the FeGe helimagnet by electric current. Here, we report the motion tracking and control of a single skyrmion at room temperature in the chiral-lattice magnet Co9Zn9Mn2 using nanosecond current pulses. We have directly observed that the skyrmion Hall motion reverses its direction upon the reversal of skyrmion topological number using Lorentz transmission electron microscopy. Systematic measurements of the single-skyrmion trace as a function of electric current reveal a dynamic transition from the static pinned state to the linear flow motion via a creep event, in agreement with the theoretical prediction. We have clarified the role of skyrmion pinning and evaluated the intrinsic skyrmion Hall angle and the skyrmion velocity in the course of the dynamic transition. Our results pave a way to skyrmion applications in spintronic devices.
Bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquitos
Authors: Viswanatha Raghuvir , Mameli Enzo , Rodiger Jonathan , Merckaert Pierre , Feitosa-Suntheimer Fabiana , Colpitts Tonya M. , Mohr Stephanie E. , Hu Yanhui , Perrimon Norbert 
Published: November 2021

AbstractMosquito-borne diseases present a worldwide public health burden. Current efforts to understand and counteract them have been aided by the use of cultured mosquito cells. Moreover, application in mammalian cells of forward genetic approaches such as CRISPR screens have identified essential genes and genes required for host-pathogen interactions, and in general, aided in functional annotation of genes. An equivalent approach for genetic screening of mosquito cell lines has been lacking. To develop such an approach, we design a new bioinformatic portal for sgRNA library design in several mosquito genomes, engineer mosquito cell lines to express Cas9 and accept sgRNA at scale, and identify optimal promoters for sgRNA expression in several mosquito species. We then optimize a recombination-mediated cassette exchange system to deliver CRISPR sgRNA and perform pooled CRISPR screens in anAnophelescell line. Altogether, we provide a platform for high-throughput genome-scale screening in cell lines from disease vector species.
LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade
Authors: Liu Yi , Debo Brian , Li Mingfeng , Shi Zhennan , Sheng Wanqiang , Shi Yang 
Published: November 2021

AbstractExhausted CD8+ T cells are key targets of immune checkpoint blockade therapy and their ineffective reinvigoration limits the durable benefit in some cancer patients. Here, we demonstrate that histone demethylase LSD1 acts to enforce an epigenetic program in progenitor exhausted CD8+ T cells to antagonize the TCF1-mediated progenitor maintenance and to promote terminal differentiation. Consequently, genetic perturbation or small molecules targeting LSD1 increases the persistence of the progenitor exhausted CD8+ T cells, which provide a sustained source for the proliferative conversion to numerically larger terminally exhausted T cells with tumor-killing cytotoxicity, thereby leading to effective and durable responses to anti-PD1 therapy. Collectively, our findings provide important insights into epigenetic mechanisms that regulate T cell exhaustion and have important implications for durable immunotherapy.
Wolbachia cifB induces cytoplasmic incompatibility in the malaria mosquito vector
Authors: Adams Kelsey L. , Abernathy Daniel G. , Willett Bailey C. , Selland Emily K. , Itoe Maurice A. , Catteruccia Flaminia 
Published: November 2021

AbstractWolbachia, a maternally inherited intracellular bacterial species, can manipulate host insect reproduction by cytoplasmic incompatibility (CI), which results in embryo lethality in crosses between infected males and uninfected females. CI is encoded by two prophage genes, cifA and cifB. Wolbachia, coupled with the sterile insect technique, has been used in field trials to control populations of the dengue vector Aedes albopictus, but CI-inducing strains are not known to infect the malaria vector Anopheles gambiae. Here we show that cifA and cifB can induce conditional sterility in the malaria vector An. gambiae. We used transgenic expression of these Wolbachia-derived genes in the An. gambiae germline to show that cifB is sufficient to cause embryonic lethality and that cifB-induced sterility is rescued by cifA expression in females. When we co-expressed cifA and cifB in male mosquitoes, the CI phenotype was attenuated. In female mosquitoes, cifB impaired fertility, which was overcome by co-expression of cifA. Our findings pave the way towards using CI to control malaria mosquito vectors.
Incorporation mechanism of Fe and Al into bridgmanite in a subducting mid-ocean ridge basalt and its crystal chemistry
Authors: Nakatsuka Akihiko , Fukui Hiroshi , Kamada Seiji , Hirao Naohisa , Ohkawa Makio , Sugiyama Kazumasa , Yoshino Takashi 
Published: November 2021

AbstractThe compositional difference between subducting slabs and their surrounding lower-mantle can yield the difference in incorporation mechanism of Fe and Al into bridgmanite between both regions, which should cause heterogeneity in physical properties and rheology of the lower mantle. However, the precise cation-distribution has not been examined in bridgmanites with Fe- and Al-contents expected in a mid-ocean ridge basalt component of subducting slabs. Here we report on Mg0.662Fe0.338Si0.662Al0.338O3 bridgmanite single-crystal characterized by a combination of single-crystal X-ray diffraction, synchrotron 57Fe-Mössbauer spectroscopy and electron probe microanalysis. We find that the charge-coupled substitution AMg2+  + BSi4+  ↔ AFe3+(high-spin) + BAl3+ is predominant in the incorporation of Fe and Al into the practically eightfold-coordinated A-site and the sixfold-coordinated B-site in bridgmanite structure. The incorporation of both cations via this substitution enhances the structural distortion due to the tilting of BO6 octahedra, yielding the unusual expansion of mean <A–O> bond-length due to flexibility of A–O bonds for the structural distortion, in contrast to mean <B–O> bond-length depending reasonably on the ionic radius effect. Moreover, we imply the phase-transition behavior and the elasticity of bridgmanite in slabs subducting into deeper parts of the lower mantle, in terms of the relative compressibility of AO12 (practically AO8) and BO6 polyhedra.
First observation of radiolytic bubble formation in unstirred nano-powder sludges and a consistent model thereof
Authors: O’Leary Mel , Baidak Aliaksandr , Barnes Martyn , Donoclift Thomas , Emerson Christopher , Figueira Catarina , Fox Oliver , Kleppe Annette , McCulloch Aaron , Messer Darryl , Orr Robin , Currell Fred 
Published: November 2021

AbstractExperiments involving the irradiation of water contained within magnesium hydroxide and alumina nanoparticle sludges were conducted and culminated in observations of an increased yield of molecular hydrogen when compared to the yield from the irradiation of bulk water. We show that there is a relationship linking this increased yield to the direct nanoscale ionization mechanism in the nanoparticles, indicating that electron emission from the nanoparticles drives new radiative pathways in the water. Because the chemical changes in these sludges are introduced by irradiation only, we have a genuinely unstirred system. This feature allows us to determine the diffusivity of the dissolved gas. Using the measured gas production rate, we have developed a method for modelling when hydrogen bubble formation will occur within the nanoparticle sludges. This model facilitates the determination of a consistent radiolytic consumption rate coinciding with the observations of bubble formation. Thus, we demonstrate a nanoscale radiation effect directly influencing the formation of molecular hydrogen.
Association of lockdowns with the protective role of ultraviolet-B (UVB) radiation in reducing COVID-19 deaths
Authors: Moozhipurath Rahul Kalippurayil , Kraft Lennart 
Published: November 2021

AbstractNations are imposing unprecedented measures at a large scale to contain the spread of the COVID-19 pandemic. While recent studies show that non-pharmaceutical intervention measures such as lockdowns may have mitigated the spread of COVID-19, those measures also lead to substantial economic and social costs, and might limit exposure to ultraviolet-B radiation (UVB). Emerging observational evidence indicates the protective role of UVB and vitamin D in reducing the severity and mortality of COVID-19 deaths. This observational study empirically outlines the protective roles of lockdown and UVB exposure as measured by the ultraviolet index (UVI). Specifically, we examine whether the severity of lockdown is associated with a reduction in the protective role of UVB exposure. We use a log-linear fixed-effects model on a panel dataset of secondary data of 155 countries from 22 January 2020 until 7 October 2020 (n = 29,327). We use the cumulative number of COVID-19 deaths as the dependent variable and isolate the mitigating influence of lockdown severity on the association between UVI and growth rates of COVID-19 deaths from time-constant country-specific and time-varying country-specific potentially confounding factors. After controlling for time-constant and time-varying factors, we find that a unit increase in UVI and lockdown severity are independently associated with − 0.85 percentage points (p.p) and − 4.7 p.p decline in COVID-19 deaths growth rate, indicating their respective protective roles. The change of UVI over time is typically large (e.g., on average, UVI in New York City increases up to 6 units between January until June), indicating that the protective role of UVI might be substantial. However, the widely utilized and least severe lockdown (governmental recommendation to not leave the house) is associated with the mitigation of the protective role of UVI by 81% (0.76 p.p), which indicates a downside risk associated with its widespread use. We find that lockdown severity and UVI are independently associated with a slowdown in the daily growth rates of cumulative COVID-19 deaths. However, we find evidence that an increase in lockdown severity is associated with significant mitigation in the protective role of UVI in reducing COVID-19 deaths. Our results suggest that lockdowns in conjunction with adequate exposure to UVB radiation might have even reduced the number of COVID-19 deaths more strongly than lockdowns alone. For example, we estimate that there would be 11% fewer deaths on average with sufficient UVB exposure during the period people were recommended not to leave their house. Therefore, our study outlines the importance of considering UVB exposure, especially while implementing lockdowns, and could inspire further clinical studies that may support policy decision-making in countries imposing such measures.