bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic fields in elliptical galaxies: using the Laing–Garrington effect in radio galaxies and polarized emission from background radio sources
Authors: Shah Hilay , Seta Amit 
Published: September 2021

ABSTRACTMagnetic fields in elliptical galaxies are poorly constrained because of a lack of significant synchrotron emission from them. In this paper, we explore the properties of magnetic fields in ellipticals using two methods. First, we exploit the Laing–Garrington effect (asymmetry in the observed polarization fraction between radio galaxy jets) for 57 galaxies with redshifts up to 0.5. We use the differences in polarization fraction and rotation measure between the jet and counterjet to estimate the small- and large-scale magnetic fields in and around ellipticals (including their circumgalactic medium). We find that the small-scale field (at scales smaller than the driving scale of turbulence, approximately 300 pc) lies in the range 0.1–2.75 $\mu{\rm G}$. The large-scale field (at scales of 100 kpc) is an order of magnitude smaller than the small-scale field. In the second method, we cross-match the Faraday rotation measures (RMs) of a few hundred (out of 3098) extragalactic radio sources with galaxy catalogues to explore the effect of the number and morphology of intervening galaxies on the observed RM distribution. We use both Gaussian and non-Gaussian functions to describe the RM distribution and to derive its statistical properties. Finally, using the difference in the observed polarization fraction between the intervening spirals and ellipticals, we estimate the small-scale magnetic fields at the centre of ellipticals to be ∼6 $\mu{\rm G}$. Both methods with different observations and analysis techniques give magnetic field strengths consistent with previous studies (≤10 $\mu{\rm G}$). The results can be used to constrain dynamo theories and galaxy evolution simulations.
Norms of Textual Scansion and Rhyme in Beatles AABA Forms
Authors: Heetderks David 
Published: September 2021

AbstractIn AABA songs (sometimes called verse–bridge songs) written and performed by the Beatles, the song texts’ scansion and rhyme show significant contrasts between different sections, and these contrasts often have important formal and narrative functions. Combining rock Formenlehre with phonetic analysis, this article shows that A modules tend to have irregular scansion and frequent rhyme, while B modules tend to show regular scansion and less frequent rhyme. In the unusual cases where A modules have infrequent rhyme, the B modules tend to offer contrast by showing greater rhyme frequency. These contrasts represent an independent, recurring formal device in the Beatles’ catalogue that does not entirely comport with other well-defined formal processes, such as the loose-verse/tight-chorus schema. The scansion and rhyme have various narrative and formal functions: They often suggest a contrast between an active and passive state in the song’s protagonist, and disruptions to regular patterns or conflict with grammatical boundaries can play a critical role in shaping phrases. B modules that thwart the norm can connote an especially high emotional arousal or suggest a process of intensification and conclusion, linking the form to an expanded statement–response–departure–conclusion form. The analyses demonstrate the central role that prosody often plays in popular song and show the importance of considering its relation to other musical patterns.
Cognitive disorders in patients with chronic kidney disease: specificities of clinical assessment
Authors: Pépin Marion , Ferreira Ana Carina , Arici Mustafa , Bachman Maie , Barbieri Michelangela , Bumblyte Inga Arune , Carriazo Sol , Delgado Pilar , Garneata Liliana , Giannakou Konstantinos , Godefroy Olivier , Grodzicki Tomasz , Klimkowicz-Mrowiec Aleksandra , Kurganaite Justina , Liabeuf Sophie , Mocanu Carmen Antonia , Paolisso Giuseppe , Spasovski Goce , Vazelov Evgueniy Stefanov , Viggiano Davide , Zoccali Carmine , Massy Ziad A , Więcek Andrzej ,   CONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative Target), Capasso Giovambattista , Andrade Alexandre , Bachmann Maie , Bumblyte Inga , Covic Adrian Constantin , Delgado Pilar , Endlich Nicole , Engvig Andreas , Fouque Denis , Franssen Casper , Frische Sebastian , Garneata Liliana , Gesualdo Loreto , Giannakou Konstantinos , Goumenos Dimitrios , Kartal Ayşe Tuğba , Mani Laila-Yasmin , Marti Hans-Peter , Mayer Christopher , Nielsen Rikke , Pešić Vesna , Rroji Merita , Sakkas Giorgos , Spasovski Goce , Stevens Kate I , Vazelov Evgueniy , Viggiano Davide , Zacharia Lefteris , Ferreira Ana Carina , Malyszko Jolanta , Hoorn Ewout , Figurek Andreja , Unwin Robert , Wagner Carsten , Wanner Christoph , Bruchfeld Annette , Pepin Marion , Wiecek Andrzej , Nitsch Dorothea , Fridolin Ivo , Hafez Gaye , Romeo Maria José Soler , Barbieri Michelangela , Batinić Bojan , Carrasco Laura , Carriazo Sol , Gansevoort Ron , Martino Gianvito , Raso Francesco Mattace , Nistor Ionut , Ortiz Alberto , Paolisso Giuseppe , Rastenytė Daiva , Stefan Gabriel , Tedeschi Gioacchino , Massy Ziad , Bikbov Boris , Endlich Karl Hans , Godefroy Olivier , Chillon Jean-Marc , Kossioni Anastassia , Kurganaite Justina , Perico Norberto , Remuzzi Giuseppe , Grodzicki Tomasz , Trepiccione Francesco , Zoccali Carmine , Arici Mustafa , Blankestijn Peter , Eckardt Kai-Uwe , Fliser Danilo , Jiménez Eugenio Gutiérrez , Konig Maximilian , Rychlik Ivan , Deleidi Michela , Reusz George 
Published: September 2021

ABSTRACT
Neurocognitive disorders are frequent among chronic kidney disease (CKD) patients. Identifying and characterizing cognitive impairment (CI) can help to assess the ability of adherence to CKD risk reduction strategy, identify potentially reversible causes of cognitive decline, modify pharmacotherapy, educate the patient and caregiver and provide appropriate patient and caregiver support. Numerous factors are associated with the development and progression of CI in CKD patients and various conditions can influence the results of cognitive assessment in these patients. Here we review clinical warning signs that should lead to cognitive screening; conditions frequent in CKD at risk to interfere with cognitive testing or performance, including specificities of cognitive assessment in dialysis patients or after kidney transplantation; and available tests for screening and observed cognitive patterns in CKD patients.
Prevalence of non-alcoholic fatty liver disease in patients with chronic kidney disease: a cross-sectional study
Authors: Adrian Therese , Sørensen Ida M H , Knop Filip K , Bro Susanne , Ballegaard Ellen L F , Nordestgaard Børge G , Fuchs Andreas , Kofoed Klaus F , Kühl Jørgen T , Sigvardsen Per E , Hornum Mads , Feldt-Rasmussen Bo 
Published: September 2021

Abstract

Background
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease and represents a wide spectrum ranging from mild steatosis to non-alcoholic steatohepatitis with or without fibrosis to overt cirrhosis. Patients with NAFLD have a high risk of developing cardiovascular disease and chronic kidney disease (CKD). So far there has been scarce evidence of the prevalence of NAFLD among patients with CKD. We investigated the prevalence of moderate–severe hepatic steatosis graded according to the definition of NAFLD in a cohort of patients with CKD.

Methods
Hepatic liver fat content was evaluated by computed tomography (CT) scan in 291 patients from the Copenhagen CKD Cohort Study and in 866 age- and sex-matched individuals with normal kidney function from the Copenhagen General Population Study. Liver attenuation density &lt;48 HU was used as a cut-off value for moderate–severe hepatic steatosis.

Results
The prevalence of moderate–severe hepatic steatosis was 7.9 and 10.7% (P = 0.177) among patients with CKD and controls, respectively. No association between liver fat content and CKD stage was found. In the pooled dataset from both cohorts, adjusted odds ratios for moderate–severe hepatic steatosis among persons with diabetes, overweight and obesity were 3.1 [95% confidence interval (CI) 1.6–5.9], 14.8 (95% CI 4.6–47.9) and 42.0 (95% CI 12.9–136.6), respectively.

Conclusions
In a cohort of 291 patients with CKD, kidney function was not associated with the prevalence of moderate–severe hepatic steatosis as assessed by CT scan.
The benefit of early surgery on overall survival in incidental low-grade glioma patients: A multicenter study
Authors: Ius Tamara , Ng Sam , Young Jacob S , Tomasino Barbara , Polano Maurizio , Ben-Israel David , Kelly John J P , Skrap Miran , Duffau Hugues , Berger Mitchel S 
Published: September 2021

Abstract

Background
The role of surgery for incidentally discovered diffuse incidental low-grade gliomas (iLGGs) is debatable and poorly documented in current literature.

Objective
The aim was to identify factors that influence survival for patients that underwent surgical resection of iLGGs in a large multicenter population.

Methods
Clinical, radiological, and surgical data were retrospectively analyzed in 267 patients operated for iLGG from 4 neurosurgical Centers. Univariate and multivariate analyses were performed to identify predictors of overall survival (OS) and tumor recurrence (TR).

Results
The OS rate was 92.41%. The 5- and 10-year estimated OS rates were 98.09% and 93.2%, respectively. OS was significantly longer for patients with a lower preoperative tumor volume (P = .001) and higher extent of resection (EOR) (P = .037), regardless the WHO-defined molecular class (P = .2). In the final model, OS was influenced only by the preoperative tumor volume (P = .006), while TR by early surgery (P = .028). A negative association was found between preoperative tumor volumes and EOR (rs = −0.44, P &lt; .001). The median preoperative tumor volume was 15 cm3. The median EOR was 95%. Total or supratotal resection of T2-FLAIR abnormality was achieved in 61.62% of cases. Second surgery was performed in 26.22%. The median time between surgeries was 5.5 years. Histological evolution to high-grade glioma was detected in 22.85% of cases (16/70). Permanent mild deficits were observed in 3.08% of cases.

Conclusions
This multicenter study confirms the results of previous studies investigating surgical management of iLGGs and thereby strengthens the evidence in favor of early surgery for these lesions.
Is There a Role for Surgical Resection of Multifocal Glioblastoma? A Retrospective Analysis of 100 Patients
Authors: Friso Filippo , Rucci Paola , Rosetti Vittoria , Carretta Alessandro , Bortolotti Carlo , Ramponi Vania , Martinoni Matteo , Palandri Giorgio , Zoli Matteo , Badaloni Filippo , Franceschi Enrico , Asioli Sofia , Fabbri Viscardo Paolo , Rustici Arianna , Foschini Maria P , Brandes Alba A , Mazzatenta Diego , Sturiale Carmelo , Conti Alfredo 
Published: September 2021

Abstract

BACKGROUND
Glioblastoma with multiple localizations (mGBMs) can be defined as multifocal, where enhancing lesions present a connection visible on magnetic resonance imaging fluid-attenuated inversion recovery imaging, or multicentric, in the absence of a clear dissemination pathway.

OBJECTIVE
To evaluate the role of the extent of resection (EOR) in the treatment of mGBMs and its correlation with overall survival (OS) and progression free survival (PFS).

METHODS
One hundred patients with mGBMs were treated at our Institution between 2009 and 2019. Clinical, radiological, and follow-up data were collected. EOR of the contrast-enhancing part of lesions was classified as gross total resection (GTR, absence of tumor remnant), subtotal resection (STR, residual tumor < 30% of the initial mass), partial resection (PR, residual tumor > 30% of the initial mass), and needle or open biopsy (residual tumor > 75% of the initial mass).

RESULTS
Approximately 15% of patients underwent GTR, 14% STR, 32% PR, and 39% biopsy. Median OS was 17 mo for GTR, 11 mo for STR, 7 mo for PR, and 5 mo for biopsy. Greater EOR was associated with a significantly longer OS than biopsy. GTR and STR were associated with a longer PFS in Kaplan-Meier survival analyses. After adjusting for age, Karnofsky performance status (KPS), number of lesions, and adjunctive therapy in multivariable Cox regression analyses, GTR, STR, and PR were still associated with OS, but only GTR remained associated with PFS.

CONCLUSION
Our study suggests that EOR may positively influence survival of patients with mGBM. Surgical resection can be a reasonable option when performance and access to adjuvant treatment can be preserved.
Cognitive and Psychological Functioning in Chiari Malformation Type I Before and After Surgical Decompression - A Prospective Cohort Study
Authors: Seaman Scott C , Streese Carolina Deifelt , Manzel Kenneth , Kamm Janina , Menezes Arnold H , Tranel Daniel , Dlouhy Brian J 
Published: September 2021

Abstract

BACKGROUND
Chiari Malformation Type I (CM-I) is defined as cerebellar tonsil displacement more than 5 mm below the foramen magnum. This displacement can alter cerebrospinal fluid flow at the cervicomedullary junction resulting in Valsalva-induced headaches and syringomyelia and compress the brainstem resulting in bulbar symptoms. However, little is known about cognitive and psychological changes in CM-I.

OBJECTIVE
To prospectively assess cognitive and psychological performance in CM-I and determine whether changes occur after surgical decompression.

METHODS
Blinded evaluators assessed symptomatic CM-I patients ages ≥18 with a battery of neuropsychological and psychological tests. Testing was conducted preoperatively and 6 to 18 mo postoperatively. Data were converted to Z-scores based on normative data, and t-tests were used to analyze pre-post changes.

RESULTS
A total of 26 patients were included, with 19 completing both pre- and post-op cognitive assessments. All patients had resolution of Valsalva-induced headaches and there was improvement in swallowing dysfunction (P < .0001), ataxia (P = .008), and sleep apnea (P = .021). Baseline performances in visual perception and construction (z = −1.11, P = .001) and visuospatial memory (z = −0.93, P = .002) were below average. Pre-post comparisons showed that CM-I patients had stable cognitive and psychological functioning after surgery, without significant changes from preoperative levels.

CONCLUSION
CM-I patients had below average performance in visuospatial and visuoconstructional abilities preoperatively. Prospective longitudinal data following surgery demonstrated improved neurologic status without any decline in cognition or psychological functioning. Routine pre- and postoperative formal neuropsychological assessment in CM-I patients help quantify cognitive and behavioral changes associated with surgical decompression.
5-Aminolevulinic Acid-Induced Porphyrin Contents in Various Brain Tumors: Implications Regarding Imaging Device Design and Their Validation
Authors: Suero Molina Eric , Kaneko Sadahiro , Black David , Stummer Walter 
Published: September 2021

Abstract

BACKGROUND
Fluorescence-guided resections using 5-aminolevulinic acid (5-ALA)-induced tumor porphyrins have been established as an adjunct for malignant glioma surgery based on a phase III study using specifically adapted microscopes for visualizing fluorescing protoporphyrin IX (PPIX). New hardware technologies are being introduced, which claim the same performance as the original technology for visualizing fluorescence. This assumes that qualitative fluorescence detection is equivalent to the established standard, an assumption that needs to be critically assessed.

OBJECTIVE
To determine PPIX concentrations (cPPIX) in tissue that can be detected visually using the established BLUE400 filter system (Carl Zeiss Meditec, Oberkochen, Germany) as a basis for defining the performance of this system.

METHODS
Utilizing a hyperspectral imaging system, tumor samples from patients harboring different tumor tissues, with or without visible fluorescence, were analyzed. Absolute values of cPPIX were calculated after calibrating the system with fluorescence phantoms with known cPPIX.

RESULTS
A total of 524 tumor samples from 162 patients were analyzed. Visual fluorescence under the BLUE400 filter was documented by experienced neurosurgeons. A 0.9 μg/ml threshold of cPPIX was defined as the minimal concentration required to detect and discriminate visual fluorescence.

CONCLUSION
This is the first report providing data on the threshold of cPPIX, which is visually detected using the current generation of microscopes, thus defining the specificity and sensitivity of this technology as initially tested in a randomized trial. Novel technologies should show similar characteristics in order to be used safely and effectively. If more sensitive, such technologies require further assessments of tumor selectivity.
Negligible Systemic Uptake of Suprafascial Vancomycin Powder Following Instrumented Posterior Spinal Fusion—Preliminary Results From A Randomized Clinical Trial (VANCO Trial)
Authors: Schär Ralph T , Jesse C Marvin , Montalbetti Matteo , Söll Nicole , Lutz Katharina , Steinsiepe Valentin , Branca Mattia , Raabe Andreas , Zimmerli Stefan 
Published: September 2021

Abstract

BACKGROUND
Intrawound vancomycin powder is an emerging strategy to reduce surgical site infections (SSIs) in spine surgery. However, there are concerns relating to its safety profile and toxicity. Data on systemic uptake of suprafascially administered vancomycin powder following instrumented spinal fusion is lacking.

OBJECTIVE
To study the systemic uptake and safety of suprafascially administered vancomycin powder in the early postoperative phase following open instrumented posterior spinal fusion.

METHODS
This was a substudy of an ongoing randomized clinical trial. Eligible adult patients were randomized 1:1 to either receive suprafascial vancomycin powder before wound closure or not to receive vancomycin powder. Serum vancomycin levels were assessed on postoperative days 1 and 2, serum creatinine levels were measured pre- and post-operatively. Adverse events up to 6 wk following surgery were recorded.

RESULTS
Among 34 randomized patients (mean age 62 yr, range 31-84 yr; 18 [53%] women), 17 received vancomycin powder. No detectable serum vancomycin levels (>4.0 mg/L) were found. Proportion of adverse events per patient in the vancomycin and control group, respectively, were 29.4% (5/17) vs 11.8% (2/17) (OR 3.12; 95% CI, 0.52; 19.38; P = .398). No patient had nephrotoxicity or ototoxicity in either group.

CONCLUSION
Suprafascial vancomycin powder in open instrumented spinal fusion surgery is safe and results in negligible systemic uptake. Final results of the VANCO Trial need to be awaited for conclusive data on the efficacy of vancomycin for SSI prevention and its impact on wound healing.
Recent progress in the synthesis of novel two-dimensional van der Waals materials
Authors: Bian Renji , Li Changcun , Liu Qing , Cao Guiming , Fu Qundong , Meng Peng , Zhou Jiadong , Liu Fucai , Liu Zheng 
Published: September 2021

Abstract
The last decade has witnessed the significant progress of physical fundamental research and great success of practical application in two-dimensional (2D) van der Waals (vdW) materials since the discovery of graphene in 2004. To date, vdW materials is still a vibrant and fast-expanding field, where tremendous reports have been published covering topics from cutting-edge quantum technology to urgent green energy, and so on. Here, we briefly review the emerging hot physical topics and intriguing materials, such as 2D topological materials, piezoelectric materials, ferroelectric materials, magnetic materials and twistronic heterostructures. Then, various vdW material synthetic strategies are discussed in detail, concerning the growth mechanisms, preparation conditions and typical examples. Finally, prospects and further opportunities in the booming field of 2D materials are addressed.
Copper acetate-facilitated transfer-free growth of high-quality graphene for hydrovoltaic generators
Authors: Shan Jingyuan , Fang Sunmiao , Wang Wendong , Zhao Wen , Zhang Rui , Liu Bingzhi , Lin Li , Jiang Bei , Ci Haina , Liu Ruojuan , Wang Wen , Yang Xiaoqin , Guo Wenyue , Rümmeli Mark H , Guo Wanlin , Sun Jingyu , Liu Zhongfan 
Published: September 2021

Abstract
Direct synthesis of high-quality graphene on dielectric substrates without a transfer process is of vital importance for a variety of applications. Current strategies for boosting high-quality graphene growth, such as remote metal catalyzation, are limited by poor performance with respect to the release of metal catalysts and hence suffer from a problem with metal residues. Herein, we report an effective approach that utilizes a metal-containing species, copper acetate, to continuously supply copper clusters in a gaseous form to aid transfer-free growth of graphene over a wafer scale. The thus-derived graphene films were found to show reduced multilayer density and improved electrical performance and exhibited a carrier mobility of 8500 cm2 V−1 s−1. Furthermore, droplet-based hydrovoltaic electricity generator devices based on directly grown graphene were found to exhibit robust voltage output and long cyclic stability, in stark contrast to their counterparts based on transferred graphene, demonstrating the potential for emerging energy harvesting applications. The work presented here offers a promising solution to organize the metal catalytic booster toward transfer-free synthesis of high-quality graphene and enable smart energy generation.
Advances in understanding the formation and fate of B-cell memory in response to immunization or infection
Authors: Kealy Liam , Good-Jacobson Kim L 
Published: September 2021

Abstract
Immunological memory has the potential to provide lifelong protection against recurrent infections. As such, it has been crucial to the success of vaccines. Yet, the recent pandemic has illuminated key gaps in our knowledge related to the factors influencing effective memory formation and the inability to predict the longevity of immune protection. In recent decades, researchers have acquired a number of novel and powerful tools with which to study the factors underpinning humoral memory. These tools have been used to study the B-cell fate decisions that occur within the germinal centre (GC), a site where responding B cells undergo affinity maturation and are one of the major routes for memory B cell and high-affinity long-lived plasma cell formation. The advent of single-cell sequencing technology has provided an enhanced resolution for studying fate decisions within the GC and cutting-edge techniques have enabled researchers to model this reaction with more accuracy both in vitro and in silico. Moreover, modern approaches to studying memory B cells have allowed us to gain a better appreciation for the heterogeneity and adaptability of this vital class of B cells. Together, these studies have facilitated important breakthroughs in our understanding of how these systems operate to ensure a successful immune response. In this review, we describe recent advances in the field of GC and memory B-cell biology in order to provide insight into how humoral memory is formed, as well as the potential for generating lasting immunity to novel pathogens such as severe acute respiratory syndrome coronavirus 2.