bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional analysis of tomato CHIP ubiquitin E3 ligase in heat tolerance
Authors: Zhang Yan , Lai Xiaodong , Yang Siqing , Ren Huan , Yuan Jingya , Jin Huanchun , Shi Chengchen , Lai Zhibing , Xia Gengshou 
Published: January 2021

AbstractPlants have evolved genetic and physiological mechanisms to mitigate the adverse effects of high temperature. CARBOXYL TERMINUS OF THE HSC70-INTERACTING PROTEINS (CHIP) is a conserved chaperone-dependent ubiquitin E3 ligase that targets misfolded proteins. Here, we report functional analysis of the SlCHIP gene from tomato (Solanum lycopersicum) in heat tolerance. SlCHIP encodes a CHIP protein with three tandem tetracopeptide repeat (TPR) motifs and a C-terminal U box domain. Phylogenetic analysis of CHIP homologs from animals, spore-bearing and seed plants revealed a tree topology similar to the evolutionary tree of the organisms. Expression of SlCHIP was induced under high temperature and was also responsive to plant stress hormones. Silencing of SlCHIP in tomato reduced heat tolerance based on increased heat stress symptoms, reduced photosynthetic activity, elevated electrolyte leakage and accumulation of insoluble protein aggregates. The accumulated protein aggregates in SlCHIP-silenced plants were still highly ubiquitinated, suggesting involvement of other E3 ligases in ubiquitination. SlCHIP restored the heat tolerance of Arabidopsis chip mutant to the wild type levels. These results indicate that tomato SlCHIP plays a critical role in heat stress responses most likely by targeting degradation of misfolded proteins that are generated during heat stress.
Fibroblast activation protein targeted near infrared photoimmunotherapy (NIR PIT) overcomes therapeutic resistance in human esophageal cancer
Authors: Katsube Ryoichi , Noma Kazuhiro , Ohara Toshiaki , Nishiwaki Noriyuki , Kobayashi Teruki , Komoto Satoshi , Sato Hiroaki , Kashima Hajime , Kato Takuya , Kikuchi Satoru , Tazawa Hiroshi , Kagawa Shunsuke , Shirakawa Yasuhiro , Kobayashi Hisataka , Fujiwara Toshiyoshi 
Published: January 2021

AbstractCancer-associated fibroblasts (CAFs) have an important role in the tumor microenvironment. CAFs have the multifunctionality which strongly support cancer progression and the acquisition of therapeutic resistance by cancer cells. Near-infrared photoimmunotherapy (NIR-PIT) is a novel cancer treatment that uses a highly selective monoclonal antibody (mAb)-photosensitizer conjugate. We developed fibroblast activation protein (FAP)-targeted NIR-PIT, in which IR700 was conjugated to a FAP-specific antibody to target CAFs (CAFs-targeted NIR-PIT: CAFs-PIT). Thus, we hypothesized that the control of CAFs could overcome the resistance to conventional chemotherapy in esophageal cancer (EC). In this study, we evaluated whether EC cell acquisition of stronger malignant characteristics and refractoriness to chemoradiotherapy are mediated by CAFs. Next, we assessed whether the resistance could be rescued by eliminating CAF stimulation by CAFs-PIT in vitro and in vivo. Cancer cells acquired chemoradiotherapy resistance via CAF stimulation in vitro and 5-fluorouracil (FU) resistance in CAF-coinoculated tumor models in vivo. CAF stimulation promoted the migration/invasion of cancer cells and a stem-like phenotype in vitro, which were rescued by elimination of CAF stimulation. CAFs-PIT had a highly selective effect on CAFs in vitro. Finally, CAF elimination by CAFs-PIT in vivo demonstrated that the combination of 5-FU and NIR-PIT succeeded in producing 70.9% tumor reduction, while 5-FU alone achieved only 13.3% reduction, suggesting the recovery of 5-FU sensitivity in CAF-rich tumors. In conclusion, CAFs-PIT could overcome therapeutic resistance via CAF elimination. The combined use of novel targeted CAFs-PIT with conventional anticancer treatments can be expected to provide a more effective and sensible treatment strategy.
AlO6 clusters’ electric storage effect in amorphous alumina supercapacitors
Authors: Fukuhara Mikio , Kuroda Tomoyuki , Hasegawa Fumihiko , Hashida Toshiyuki , Takeda Mitsuhiro , Konno Kazuya , Fujima Nobuhisa 
Published: January 2021

AbstractIn this study, the electric storage effect of AlO6 clusters in amorphous alumina (AAO) supercapacitors was investigated in terms of cluster morphologies under electron-beam irradiation. Based on first-principles density functional calculation, the optimised structure of AlO6 clusters around an O-vacancy is characterised by a large vacant space created by the absence of an O atom and its neighbouring Al atom. The localised electrons present near the two-atomic vacancies induce positive charges on the inside of the insulating oxide surface, ensuring the adsorption of many electrons on the surface. Electron-beam irradiation (adsorption) from 100 to 180 keV causes the lengths of the Al–O bonds of the cluster to shrink, but then return to the original length with decreasing voltage energy, indicating a rocking-chair-type charge-breathing effect accompanied by a volume expansion of approximately 4%. The I–V and I–R characteristics depicted Coulomb blockade for the switching effect of both the negative and positive potentials. The Ragone plot of the AAO supercapacitor is located at capability area of the second cell.
Developing digital retail services as a tool of ensuring consumer market sustainable development in the Sverdlovsk region
Authors: Loginov Mikhail , Usova Natalia , Nedorostkova Elvira 
Published: January 2021

The article is devoted to the development of the digital retail services as the most effective and innovative tool to reinforce the Sverdlovsk regional consumer market in the context of global challenges which had a notable impact on the sustainable development of both the economy as a whole and its individual sectors.
Research subject: digitalization of the consumer market of the Sverdlovsk region
Research purpose: to explore the theoretical foundations of the consumer market, and to identify the priority directions of the Sverslovsk regional consumer market development on the based on the digital technologies introduction.
Research methods. In the course of the research, the authors used such methods as analysis, grouping, comparison and synthesis.
Results:
1.The development features of retail trade services as a key segment of consumer market are revealed.
2.The author’s approach to the “digital consumer market” category and the digital consumer market classification on various grounds are presented.
3.The priority directions of the Sverdlovsk regional consumer market development from the regional authorities’s viewpoint are considered.
4. Activities for the further Sverslovsk regional consumer market development based on digital retail services advancement are proposed.
Scientific novelty: the introduction of the category “digital consumer market” into scientific circulation is proposed and substantiated, classification criteria for the digital consumer market are formulated, measures are proposed to ensure sustainable development of the consumer market in the Sverdlovsk region.
Regional development without social conflicts on municipal territories. Subjects of public municipalities’ control as institutions for forming public opinion and relieving social tension
Authors: Plotnikova Maria 
Published: January 2021

Public councils and Public chambers, as subjects of public control at the federal, regional and municipal levels, are channels for forming public opinion of citizens about the government’s activities by performing their institutional functions and tasks. Their effective activity contributes to the accumulation of public initiatives aimed at providing the region’s development, improving the level and quality of people’s life, ensuring their retransmission to the authorities for making the necessary decisions.
And if at the federal and regional levels their legal status is fixed by normative legal acts, at the municipal level there is no legal certainty to regulate the methods of creating and organizing the activities of local Public chambers.
The author conducted a study to identify efficiency criteria for the realization of the institutional functions of regional Public chambers and by necessity of efficiency criteria, formed on their basis for Public chambers and councils of the municipal level, which may differ, and by necessity of development of proposals for additional resources to increase their effectiveness.
Endocrine Dysfunction in Open Angle Glaucoma
Authors: van Oterendorp Christian 
Published: January 2021

AbstractThe eye, like all organs, is exposed to the effects of the bodyʼs endocrine system. In addition, however, local branches of the endocrine system control important organ-specific functions, such as the production and drainage of aqueous humour. Similarly, the eye as a sensory organ acts back on endocrine controlled functions of the body, for example the day-night rhythm. This article aims to illustrate the physiological and pathological interactions of the eye and the endocrine functions of the body in the context of glaucoma. 1. The renin-angiotensin-aldosterone system, which as a local system is involved in the control of aqueous humour production and outflow. 2. The hormone endothelin, which as a strong vasoconstrictor plays a role in the dysregulated perfusion of the optic nerve and retina, and 3. the disruption of the day-night rhythm in advanced glaucoma, which is thought to be caused by damage to light-sensitive ganglion cells.
Pharmacological Treatment of Schizophrenia: Japanese Expert Consensus
Authors: Sakurai Hitoshi , Yasui-Furukori Norio , Suzuki Takefumi , Uchida Hiroyuki , Baba Hajime , Watanabe Koichiro , Inada Ken , Kikuchi Yuka Sugawara , Kikuchi Toshiaki , Katsuki Asuka , Kishida Ikuko , Kato Masaki 
Published: January 2021

Abstract
Introduction Conventional treatment guidelines of schizophrenia do not necessarily provide solutions on clinically important issues.
Methods A total of 141 certified psychiatrists of the Japanese Society of Clinical Neuropsychopharmacology evaluated treatment options regarding 19 clinically relevant situations in the treatment of schizophrenia with a 9-point scale (1=“disagree” and 9=“agree”).
Results First-line antipsychotics varied depending on predominant symptoms: risperidone (mean±standard deviation score, 7.9±1.4), olanzapine (7.5±1.6), and aripiprazole (6.9±1.9) were more likely selected for positive symptoms; aripiprazole (7.6±1.6) for negative symptoms; aripiprazole (7.3±1.9), olanzapine (7.2±1.9), and quetiapine (6.9±1.9) for depression and anxiety; and olanzapine (7.9±1.5) and risperidone (7.5±1.5) for excitement and aggression. While only aripiprazole was categorized as a first-line treatment for relapse prevention (7.6±1.0) in patients without noticeable symptoms, aripiprazole (8.0±1.6) and brexpiprazole (6.9±2.3) were categorized as such for social integration. First-line treatments in patients who are vulnerable to extrapyramidal symptoms include quetiapine (7.5±2.0) and aripiprazole (6.9±2.1).
Discussion These clinical recommendations represent the expert consensus on the use of a particular antipsychotic medication for a particular situation, filling a current gap in the literature.
Image-Guided Intratumoral Delivery of Immunotherapeutics in Gastrointestinal Malignancies
Authors: Qiao Yang , Sheth Rahul A. , Tam Alda 
Published: January 2021

AbstractIntratumoral (IT) administration of immunotherapy is a promising treatment strategy under clinical development for gastrointestinal malignancies. Due to its targeted nature, IT immunotherapies can generate regional proinflammatory microenvironments that result in the focal recruitment of tumor-specific immune cells. Precision targeting of tumors via IT immunotherapy injection theoretically produces a more robust immune response to the treated tumor itself and to distant metastatic tumors that share tumor-specific antigens with those of the treated tumor, while also minimizing the priming of the adaptive immune system to nonspecific antigens. Diverse arrays of IT immunotherapeutic agents including but not limited to lyophilized bacteria, viral vectors, cellular-based agents, molecules, and peptides, both as monotherapies and in combination with systemic immunotherapies, are in various stages of preclinical and clinical development. In this review, we summarize the current state of the art for IT immunotherapy and highlight potential future directions and their relevance to image-guided interventionalists.
Deep Vein Thrombosis in the Setting of Neurofibromatosis Type 1: Case Report
Authors: Guedes Fernando , Torrão Francisco , Sanches Gabriel E. , Siquara-de-Sousa Ana Caroline , von Ristow Arno , Niemeyer Filho Paulo 
Published: January 2021

AbstractNeurofibromatosis type 1 (NF1) is a genetic syndrome which typically presents with neurological manifestations. Some of the patients may also present with vasculopathies, among which arterial aneurysms and stenosis are the most common. Deep vein thrombosis (DVT) has rarely been described, and, to the best of our knowledge, the present is the first report of DVT due to venous compression by a neurofibroma in the setting of NF1.This is the case of a 23-year-old male with NF1 who experienced DVT due to compression of the left posterior tibial veins by a large tumor arising from the tibial nerve. The DVT was acutely treated with enoxaparin and then with rivaroxaban. Two months after the diagnosis, Doppler ultrasonography showed partial recanalization and persistence of the DVT. The patient was then referred to neurosurgery for surgical resection of the tumor. There were no complications during the procedure, and the patient did not present postoperative neurological deficits. The final histopathological diagnosis was of a benign neurofibroma. After one year of follow-up with vascular surgery, the patient presented no more episodes of DVT.In case there is a tumor compressing the deep vessels of the leg and promoting DVT, surgical resection with microsurgical techniques may be curative.
From the brand logo to brand associations and the corporate identity: visual and identity-based logo associations in a university merger
Authors: Erjansola Ari-Matti , Lipponen Jukka , Vehkalahti Kimmo , Aula Hanna-Mari , Pirttilä-Backman Anna-Maija 
Published: January 2021

AbstractBrand logos are a fundamental part of the corporate visual identity, and their reception has been vigorously researched. The focus has been on the visual traits of the logo and their effect on the reception process, whereas little attention has been paid to how the logo becomes part of the brand. This article narrows this research gap in investigating how a new logo is evaluated, how the perception evolves, and what underlying dimensions emerge from the reception process. We adopted a longitudinal free-association approach and followed the qualitative and quantitative changes in logo associations among first-year students at Aalto University as it was going through a merger accompanied with a radical visual-identity redesign. We show how the new logo faced initial resistance before it became a source of positive brand associations, and how it became anchored in the university´s corporate identity. We argue that logo evaluations span three dimensions: they may be congruent or incongruent with the disposition of the individual toward the change: they may be congruent or incongruent with the visual preferences of the individual; and they may be based on the visuals of the logo or on its identity-expressing capabilities.
Balancing public health and civil liberties in times of pandemic
Authors: Orzechowski Marcin , Schochow Maximilian , Steger Florian 
Published: January 2021

AbstractThe ongoing COVID-19 pandemic constitutes not only a danger for public health, but may also threaten civil liberties. Looking at the examples of recent events in Poland and Hungary, the authors argue that governments may misuse pandemic for their political advantage, thus endangering public health. Political decisions taken to stem the spread of pandemics should be limited and strictly proportionate to the situation.
Performance evaluation and enhancement of apodized fiber Bragg grating for dispersion compensation
Authors: Naguib Bassem Adel , Ata Mohamed Maher , Alzalabani Mahmoud M. , Yousif Bedir B. 
Published: January 2021

The apodization function has a significant impact on the state of the art of group delay, dispersion compensation, and acceptable decrease in side lobes in the spectrum of Fiber Bragg Grating (FBG) reflection. Accordingly, the Bragg grating length would be considered the backbone parameter in order to achieve a distinguishable performance. Here, the utilization influence of the presence of FBG is considered a dispersion compensator. In addition, we have implemented a tuned uniform-apodized FBG methodology according to various apodization functions. Common apodization functions have been studied and tested effectively. Experimental results show that the proposed raised cosine apodized function has scored the highest reflectivity with 50% reduction in the side lobe level and the narrowest bandwidth among all tested functions. Moreover, simulations for this function were performed with various lengths of grating. It is demonstrated that the reflection spectrum value is fixed at 100% at grating lengths greater than or equal to 28 mm and the minimum dispersion value is realized.
Stone–Wales defects preserve hyperuniformity in amorphous two-dimensional networks
Authors: Chen Duyu , Zheng Yu , Liu Lei , Zhang Ge , Chen Mohan , Jiao Yang , Zhuang Houlong 
Published: January 2021

SignificanceWe show that the Stone–Wales topological defects preserve hyperuniformity, a recently discovered novel state of many-body systems that suppresses large-scale density fluctuations, in defected hexagonal two-dimensional (2D) networks, spanning from perturbed crystalline structures to amorphous networks. Our findings have important implications for amorphous 2D materials since the Stone–Wales defects are well known to capture the salient feature of disorder in these materials. Our methods of building realistic hyperuniform 2D amorphous systems with large-scale electronic structure calculations are readily applicable for 2D materials discovery and design.
Grammatical categories as paradigms in Construction Grammar
Authors: Diewald Gabriele , Politt Katja 
Published: January 2021

Abstract
This squib discusses the question whether Construction Grammar can account for the assumption of universal grammatical
categories (Bybee, Perkins, and Pagliuca 1994) that are prone to language change, e.g. tense.
Most publications in Construction Grammar tackle individual constructions, such as the way-construction (Jackendoff 1990). But it remains unclear how grammatical categories as a universal phenomenon can be
described in constructionist terms. We propose that there is a way to (a) describe grammatical categories, which per definition are encoded
paradigmatically, as constructions themselves and (b) to thereby strengthen the assumption of a set of universal grammatical categories.
What would it take for us to abandon Construction Grammar?
Authors: Hoffmann Thomas 
Published: January 2021

AbstractOne of the hallmarks of scientific theories is their falsifiability, i.e. the fact that they make predictions that can objectively be proven wrong. Thus, it is paramount that researchers, including linguists, are able to state what kind of evidence would lead them to abandon their scientific theory. Yet, researchers just like all other human beings are susceptible to confirmation bias, i.e. the fact that they only seek evidence that supports their existing views. In this squib, I will raise the question whether Construction Grammar can become a falsifiable theory.
Reduplication and repetition from a constructionist perspective
Authors: Nagaya Naonori 
Published: January 2021

AbstractIn the typological literature, a distinction is often drawn between reduplication (as a morphological process) and repetition (as a syntactic process) (Gil 2005). This squib reconsiders this distinction from the perspective of Construction Morphology (Booij 2010,2018;Masini and Audring 2019). Drawing upon previously understudied phenomena in Tagalog, an Austronesian language of the Philippines, this paper demonstrates that the Construction Morphology approach provides a suitable framework for analyzing reduplication and repetition. It makes it possible to account for both similarities and differences between reduplication and repetition: both processes create a lexical unit with an iterative form and a conventionalized meaning, although they differ in the size and complexity of the lexical unit they create. Furthermore, this paper makes a strong case for the basic tenets of constructionist approaches, including a hierarchical lexicon and a lexicon-grammar continuum.
How the Entrenchment-and-Conventionalization Model might enrich Diachronic Construction Grammar
Authors: Schmid Hans-Jörg 
Published: January 2021

Abstract
Explanations of language change in terms of Diachronic Construction Grammar generalize over gradual adaptations of
the linguistic behaviour of individual speakers and communities. Presenting a diachronic case study of the pattern
(the) (Adj) thing (clauserel) is (is)
(that), I argue that the time course of formal, semantic and pragmatic changes, of changes in frequency and
of changes regarding dispersion over speakers and choices of lexical items offer a glimpse of the gradual individual and communal
adaptations underlying processes such as constructionalization and constructional change. I interpret data extracted from various
corpora from the perspectives of Diachronic Construction Grammar and the Entrenchment-and-Conventionalization Model (Schmid 2020) and discuss how the latter perspective might enrich the former.
Quarantine.
Authors: Devorshak Christina 
Published: January 2021

Abstract

Every country has an organization that serves as the National Plant Protection Organization (NPPO), charged with protecting the natural and cultivated plant resources of its territories. Preventing the introduction and spread of exotic pests is the primary function of every NPPO. Preventing introduction (i.e. the entry and establishment of a new pest, http://www.ippc.int) is significantly more efficient and more effective than attempting to 'cure' a pest problem after a pest has been introduced. We have many more options for dealing with pests while they remain offshore (e.g. pre-border) - everything from quarantines, treatments, inspection and a range of other phytosanitary measures can all be implemented to prevent new introductions. However, in spite of the best efforts of NPPOs, new pests may be introduced into our territories; and once pests have been introduced, options for dealing with such pests may be limited.
Horticultural therapy.
Authors: Morgan Lynette 
Published: January 2021

Abstract

Horticulture has been a therapeutic activity ever since human populations began to plan, create and nurture gardens for pleasure as well as for food production. The sensory stimulus and relaxation that tending plants or being in the presence of nature brings has long been known to have positive effects on mind and body. During the Middle Ages, the gardens cultivated in the grounds of monastery hospitals were used not only for the production of medicinal plants, but also for the purpose of cheering melancholy patients (McDowell, 1997). Historically the use of gardening as a therapy dates back to the 1700s when documentation showed a correlation between patients in mental institutions (known as insane asylums) who engaged in gardening activities showed improvements in their physical and mental health (Porchey, 2007). In 1798, Dr Benjamin Rush, a signer of the Declaration of Independence and while a professor of medicine and clinical practice at the University of Pennsylvania, reported that gardening improved the conditions of mentally ill patients (Park-Brown et al., 2010). It was observed that 'digging in the soil seemed to have a curative effect on the mentally ill' and sought to encourage patient participation in such activities (Olszowy, 1978).