bluuebunny/crossref_metadata_2025_split huggingface dataset:
CO2 emission accounts of Russia’s constituent entities 2005–2019
Authors: Xiao Huijuan , Zhao Weichen , Shan Yuli , Guan Dabo 
Published: July 2021

AbstractConstituent entities which make up Russia have wide-ranging powers and are considered as important policymakers and implementers of climate change mitigation. Formulation of CO2 emission inventories for Russia’s constituent entities is the priority step in achieving emission reduction. Russia is the world’s largest exporter of oil and gas combined and the fourth biggest CO2 emitter, so it’s efforts in mitigating CO2 emissions are globally significant in curbing climate change. However, the existing emission inventories only present national CO2 emissions; the subnational emission details are missing. In addition, the emission factors are not country-specific and energy activity data by fossil energy types and sectors are not sufficiently detailed. In this study, the CO2 emission inventories of Russia and its 82 constituent entities from 2005 to 2019 are constructed. The emission inventories include energy-related emissions with 89 socio-economic sectors and 17 energy types and process-related emissions. The uniformly formatted emission inventories can be a reference for in-depth analysis of emission characteristics and emission-related studies of Russia.
HtrA4 is up-regulated during trophoblast syncytialization and BeWo cells fail to syncytialize without HtrA4
Authors: Mansilla Mary , Wang Yao , Lim Rebecca , Palmer Kirsten , Nie Guiying 
Published: July 2021

AbstractThe outer layer of the human placenta comprises syncytiotrophoblast, which forms through fusion of cytotrophoblasts (syncytialization), and plays a critical role in maternal–fetal communication including nutrient/oxygen transportation and hormone secretion. Impairment in syncytialization inevitably affects pregnancy outcomes. High temperature requirement factor A 4 (HtrA4) is a placental-specific protease, expressed by various trophoblasts including syncytiotrophoblast, and significantly elevated in preeclampsia at disease presentation. However, it is unknown whether HtrA4 is important for syncytialization. Here we first examined HtrA4 expression in primary human cytotrophoblasts during syncytialization which occurs spontaneously in culture, and in BeWo cells which syncytialize upon forskolin stimulation. The success of syncytialization in each model was confirmed by significant up-regulation/secretion of β-hCG, and the concurrent down-regulation of E-cadherin. In both models, HtrA4 mRNA and protein increased concomitantly with syncytialization. Furthermore, the secreted levels of β-hCG and HtrA4 correlated significantly and positively in both models. We next knocked out HtrA4 in BeWo by CRISPR/Cas9. Upon forskolin treatment, control BeWo profoundly up-regulated β-hCG and syncytin-1, down-regulated E-cadherin, and at the same time increased the formation of multinucleated cells, whereas BeWo cells without HtrA4 did not alter any of these parameters. Our data thus suggest that HtrA4 plays an essential role in syncytialization.
Systematic review and meta-analysis of depression, anxiety, and suicidal ideation among Ph.D. students
Authors: Satinsky Emily N. , Kimura Tomoki , Kiang Mathew V. , Abebe Rediet , Cunningham Scott , Lee Hedwig , Lin Xiaofei , Liu Cindy H. , Rudan Igor , Sen Srijan , Tomlinson Mark , Yaver Miranda , Tsai Alexander C. 
Published: July 2021

AbstractUniversity administrators and mental health clinicians have raised concerns about depression and anxiety among Ph.D. students, yet no study has systematically synthesized the available evidence in this area. After searching the literature for studies reporting on depression, anxiety, and/or suicidal ideation among Ph.D. students, we included 32 articles. Among 16 studies reporting the prevalence of clinically significant symptoms of depression across 23,469 Ph.D. students, the pooled estimate of the proportion of students with depression was 0.24 (95% confidence interval [CI], 0.18–0.31; I2 = 98.75%). In a meta-analysis of the nine studies reporting the prevalence of clinically significant symptoms of anxiety across 15,626 students, the estimated proportion of students with anxiety was 0.17 (95% CI, 0.12–0.23; I2 = 98.05%). We conclude that depression and anxiety are highly prevalent among Ph.D. students. Data limitations precluded our ability to obtain a pooled estimate of suicidal ideation prevalence. Programs that systematically monitor and promote the mental health of Ph.D. students are urgently needed.
Effect of prone position on respiratory parameters, intubation and death rate in COVID-19 patients: systematic review and meta-analysis
Authors: Behesht Aeen Fatemeh , Pakzad Reza , Goudarzi Rad Mohammad , Abdi Fatemeh , Zaheri Farzaneh , Mirzadeh Narges 
Published: July 2021

AbstractProne position (PP) is known to improve oxygenation and reduce mortality in COVID-19 patients. This systematic review and meta-analysis aimed to determine the effects of PP on respiratory parameters and outcomes. PubMed, EMBASE, ProQuest, SCOPUS, Web of Sciences, Cochrane library, and Google Scholar were searched up to 1st January 2021. Twenty-eight studies were included. The Cochran's Q-test and I2 statistic were assessed heterogeneity, the random-effects model was estimated the pooled mean difference (PMD), and a meta-regression method has utilized the factors affecting heterogeneity between studies. PMD with 95% confidence interval (CI) of PaO2/FIO2 Ratio in before–after design, quasi-experimental design and in overall was 55.74, 56.38, and 56.20 mmHg. These values for Spo2 (Sao2) were 3.38, 17.03, and 7.58. PP in COVID-19 patients lead to significantly decrease of the Paco2 (PMD: − 8.69; 95% CI − 14.69 to − 2.69 mmHg) but significantly increase the PaO2 (PMD: 37.74; 95% CI 7.16–68.33 mmHg). PP has no significant effect on the respiratory rate. Based on meta-regression, the study design has a significant effect on the heterogeneity of Spo2 (Sao2) (Coefficient: 12.80; p < 0.001). No significant associations were observed for other respiratory parameters with sample size and study design. The pooled estimate for death rate and intubation rates were 19.03 (8.19–32.61) and 30.68 (21.39–40.75). The prone positioning was associated with improved oxygenation parameters and reduced mortality and intubation rate in COVID-19 related respiratory failure.
The effect of decongestion on nasal airway patency and airflow
Authors: Xiao Qiwei , Bates Alister J. , Cetto Raul , Doorly Denis J. 
Published: July 2021

AbstractNasal decongestant reduces blood flow to the nasal turbinates, reducing tissue volume and increasing nasal airway patency. This study maps the changes in nasal anatomy and measures how these changes affect nasal resistance, flow partitioning between superior and inferior cavity, flow patterns and wall shear stress. High-resolution MRI was applied to capture nasal anatomy in 10 healthy subjects before and after application of a topical decongestant. Computational fluid dynamics simulated nasal airflow at steady inspiratory flow rates of 15 L.min$$^{-1}$$

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1

and 30 L.min$$^{-1}$$

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1

. The results show decongestion mainly increases the cross-sectional area in the turbinate region and SAVR is reduced (median approximately 40$$\%$$
%
reduction) in middle and lower parts of the cavity. Decongestion reduces nasal resistance by 50$$\%$$
%
on average, while in the posterior cavity, nasal resistance decreases by a median factor of approximately 3 after decongestion. We also find decongestant regularises nasal airflow and alters the partitioning of flow, significantly decreasing flow through the superior portions of the nasal cavity. By comparing nasal anatomies and airflow in their normal state with that when pharmacologically decongested, this study provides data for a broad range of anatomy and airflow conditions, which may help characterize the extent of nasal variability.
Associations between lifetime classic psychedelic use and cardiometabolic diseases
Authors: Simonsson Otto , Osika Walter , Carhart-Harris Robin , Hendricks Peter S. 
Published: July 2021

AbstractThe objective of the current study was to investigate the associations between lifetime classic psychedelic use and cardiometabolic diseases. Using data from the National Survey on Drug Use and Health (2005–2014), the present study examined the associations between lifetime classic psychedelic use and two types of cardiometabolic disease: heart disease and diabetes. Respondents who reported having tried a classic psychedelic at least once in their lifetime had lower odds of heart disease in the past year (adjusted odds ratio (aOR) = 0.77 (0.65–0.92), p = .006) and lower odds of diabetes in the past year (adjusted odds ratio (aOR) = 0.88 (0.78–0.99), p = .036). Classic psychedelic use might be beneficial for cardiometabolic health, but more research is needed to investigate potential causal pathways of classic psychedelics on cardiometabolic diseases.
Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer
Authors: Palazón-Carrión Natalia , Jiménez-Cortegana Carlos , Sánchez-León M. Luisa , Henao-Carrasco Fernando , Nogales-Fernández Esteban , Chiesa Massimo , Caballero Rosalía , Rojo Federico , Nieto-García María-Adoración , Sánchez-Margalet Víctor , de la Cruz-Merino Luis ,   the Spanish Breast Cancer Group (GEICAM) and the Spanish Group for Immunobiotherapy of Cancer (GÉTICA)
Published: July 2021

AbstractIdentification of the different elements intervening at the tumor microenvironment seems key to explain clinical evolution in several tumor types. In this study, a set of immune biomarkers (myeloid derived suppressor cells, regulatory T cells, and OX40 + and PD-1 + T lymphocytes counts) in peripheral blood of patients diagnosed with advanced breast cancer were analyzed along of first line antineoplastic therapy. Subsequently, a comparison between groups with clinical benefit versus progression of disease and with a healthy women cohort was executed. Results reflected that patients showed higher basal levels of myeloid derived suppressor cells (35.43, IR = 180.73 vs 17.53, IR = 16.96 cells/μl; p = 0.001) and regulatory T cells (32.05, IR = 29.84 vs 22.61, IR = 13.57 cells/μl; p = 0.001) in comparison with healthy women. Furthermore, an increase in the number of activated T lymphocytes (expressing OX40), a decrease of immune inhibitory cells (MDSCs and Tregs) and inhibited T lymphocytes (expressing PD-1) were observed along the treatment in patients with clinical benefit (p ≤ 0.001). The opposite trend was observed in the case of disease progression. These findings suggest that some critical immune elements can be easily detected and measured in peripheral blood, which open a new opportunity for translational research, as they seem to be correlated with clinical evolution, at least in ABC.
Drinking coffee enhances neurocognitive function by reorganizing brain functional connectivity
Authors: Kim Hayom , Kang Sung Hoon , Kim Soon Ho , Kim Seong Hwan , Hwang Jihyeon , Kim Jae-Gyum , Han Kyungreem , Kim Jung Bin 
Published: July 2021

AbstractThe purpose of this study was to identify the mechanisms underlying effects of coffee on cognition in the context of brain networks. Here we investigated functional connectivity before and after drinking coffee using graph-theoretic analysis of electroencephalography (EEG). Twenty-one healthy adults voluntarily participated in this study. The resting-state EEG data and results of neuropsychological tests were consecutively acquired before and 30 min after coffee consumption. Graph analyses were performed and compared before and after coffee consumption. Correlation analyses were conducted to assess the relationship between changes in graph measures and those in cognitive function tests. Functional connectivity (FC) was reorganized toward more efficient network properties after coffee consumption. Performance in Digit Span tests and Trail Making Test Part B improved after coffee consumption, and the improved performance in executive function was correlated with changes in graph measures, reflecting a shift toward efficient network properties. The beneficial effects of coffee on cognitive function might be attributed to the reorganization of FC toward more efficient network properties. Based on our findings, the patterns of network reorganization could be used as quantitative markers to elucidate the mechanisms underlying the beneficial effects of coffee on cognition, especially executive function.
Fixation eye movement abnormalities and stereopsis recovery following strabismus repair
Authors: Martin Talora L. , Murray Jordan , Garg Kiran , Gallagher Charles , Shaikh Aasef G. , Ghasia Fatema F. 
Published: July 2021

AbstractWe evaluated the effects of strabismus repair on fixational eye movements (FEMs) and stereopsis recovery in patients with fusion maldevelopment nystagmus (FMN) and patients without nystagmus. Twenty-one patients with strabismus, twelve with FMN and nine without nystagmus, were tested before and after strabismus repair. Eye-movements were recorded during a gaze-holding task under monocular viewing conditions. Fast (fixational saccades and quick phases of nystagmus) and slow (inter-saccadic drifts and slow phases of nystagmus) FEMs and bivariate contour ellipse area (BCEA) were analyzed in the viewing and non-viewing eye. Strabismus repair improved the angle of strabismus in subjects with and without FMN, however patients without nystagmus were more likely to have improvement in stereoacuity. The fixational saccade amplitudes and intersaccadic drift velocities in both eyes decreased after strabismus repair in subjects without nystagmus. The slow phase velocities were higher in patients with FMN compared to inter-saccadic drifts in patients without nystagmus. There was no change in the BCEA after surgery in either group. In patients without nystagmus, the improvement of the binocular function (stereopsis), as well as decreased fixational saccade amplitude and intersaccadic drift velocity, could be due, at least partially, to central adaptive mechanisms rendered possible by surgical realignment of the eyes. The absence of improvement in patients with FMN post strabismus repair likely suggests the lack of such adaptive mechanisms in patients with early onset infantile strabismus. Assessment of fixation eye movement characteristics can be a useful tool to predict functional improvement post strabismus repair.
Placental response to maternal SARS-CoV-2 infection
Authors: Mourad Mirella , Jacob Taylor , Sadovsky Elena , Bejerano Shai , Simone Glicella Salazar-De , Bagalkot Tarique Rajasaheb , Zucker Jason , Yin Michael T. , Chang Jennifer Y. , Liu Lihong , Debelenko Larisa , Shawber Carrie J. , Firestein Morgan , Ouyang Yingshi , Gyamfi-Bannerman Cynthia , Penn Anna , Sorkin Alexander , Wapner Ronald , Sadovsky Yoel 
Published: July 2021

AbstractThe coronavirus disease 2019 (COVID-19) pandemic affected people at all ages. Whereas pregnant women seemed to have a worse course of disease than age-matched non-pregnant women, the risk of feto-placental infection is low. Using a cohort of 66 COVID-19-positive women in late pregnancy, we correlated clinical parameters with disease severity, placental histopathology, and the expression of viral entry and Interferon-induced transmembrane (IFITM) antiviral transcripts. All newborns were negative for SARS-CoV-2. None of the demographic parameters or placental histopathological characteristics were associated with disease severity. The fetal-maternal transfer ratio for IgG against the N or S viral proteins was commonly less than one, as recently reported. We found that the expression level of placentalACE2,but notTMPRSS2orFurin,was higher in women with severe COVID-19. Placental expression of IFITM1 and IFITM3, which have been implicated in antiviral response, was higher in participants with severe disease. We also showed that IFITM3 protein expression, which localized to early and late endosomes, was enhanced in severe COVID-19. Our data suggest an association between disease severity and placental SARS-CoV-2 processing and antiviral pathways, implying a role for these proteins in placental response to SARS-CoV-2.
Australia’s Black Summer pyrocumulonimbus super outbreak reveals potential for increasingly extreme stratospheric smoke events
Authors: Peterson David A. , Fromm Michael D. , McRae Richard H. D. , Campbell James R. , Hyer Edward J. , Taha Ghassan , Camacho Christopher P. , Kablick George P. , Schmidt Chris C. , DeLand Matthew T. 
Published: July 2021

AbstractThe Black Summer fire season of 2019–2020 in southeastern Australia contributed to an intense ‘super outbreak’ of fire-induced and smoke-infused thunderstorms, known as pyrocumulonimbus (pyroCb). More than half of the 38 observed pyroCbs injected smoke particles directly into the stratosphere, producing two of the three largest smoke plumes observed at such altitudes to date. Over the course of 3 months, these plumes encircled a large swath of the Southern Hemisphere while continuing to rise, in a manner consistent with existing nuclear winter theory. We connect cause and effect of this event by quantifying the fire characteristics, fuel consumption, and meteorology contributing to the pyroCb spatiotemporal evolution. Emphasis is placed on the unusually long duration of sustained pyroCb activity and anomalous persistence during nighttime hours. The ensuing stratospheric smoke plumes are compared with plumes injected by significant volcanic eruptions over the last decade. As the second record-setting stratospheric pyroCb event in the last 4 years, the Australian super outbreak offers new clues on the potential scale and intensity of this increasingly extreme fire-weather phenomenon in a warming climate.
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability
Authors: Wu Mengqiu , Chen Weiyi , Miao Mengqiu , Jin Qianqian , Zhang Shengnan , Bai Mi , Fan Jiaojiao , Zhang Yue , Zhang Aihua , Jia Zhanjun , Huang Songming 
Published: July 2021

Abstract
Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia-inducible factor (HIF) is reported to protect the kidney from acute ischemic damage and a novel HIF stabilizer, FG4592 (Roxadustat), has become available in the clinic as an anti-anemia drug. However, the role of FG4592 in the AKI-to-CKD transition remains elusive. In the present study, we investigated the role of FG4592 in the AKI-to-CKD transition induced by unilateral kidney ischemia–reperfusion (UIR). The results showed that FG4592, given to mice 3 days after UIR, markedly alleviated kidney fibrosis and enhanced renal vascular regeneration, possibly via activating the HIF-1α/vascular endothelial growth factor A (VEGFA)/VEGF receptor 1 (VEGFR1) signaling pathway and driving the expression of the endogenous antioxidant superoxide dismutase 2 (SOD2). In accordance with the improved renal vascular regeneration and redox balance, the metabolic disorders of the UIR mice kidneys were also attenuated by treatment with FG4592. However, the inflammatory response in the UIR kidneys was not affected significantly by FG4592. Importantly, in the kidneys of CKD patients, we also observed enhanced HIF-1α expression which was positively correlated with the renal levels of VEGFA and SOD2. Together, these findings demonstrated the therapeutic effect of the anti-anemia drug FG4592 in preventing the AKI-to-CKD transition related to ischemia and the redox imbalance.
Looking into the cradle of the grave: J22564–5910, a potential young post-merger hot subdwarf
Authors: Vos Joris , Pelisoli Ingrid , Budaj Jan , Reindl Nicole , Schaffenroth Veronika , Bobrick Alexey , Geier Stephan , Hermes JJ , Nemeth Peter , Østensen Roy , Reding Joshua S. , Uzundag Murat , Vučković Maja 
Published: July 2021

Context. We present the discovery of J22564–5910, a new type of hot subdwarf (sdB) which shows evidence of gas present in the system and it has shallow, multi-peaked hydrogen and helium lines which vary in shape over time. All observational evidence points towards J22564–5910 being observed very shortly after the merger phase that formed it.
Aims. Using high-resolution, high signal-to-noise spectroscopy, combined with multi-band photometry, Gaia astrometry, and TESS light curves, we aim to interpret these unusual spectral features.
Methods. The photometry, spectra, and light curves were all analysed, and their results were combined in order to support our interpretation of the observations: the likely presence of a magnetic field combined with gas features around the sdB. Based on the triple-peaked H lines, the magnetic field strength was estimated and, by using the SHELLSPEC code, qualitative models of gas configurations were fitted to the observations.
Results. All observations can either be explained by a magnetic field of ∼650 kG, which enables the formation of a centrifugal magnetosphere, or a non-magnetic hot subdwarf surrounded by a circumstellar gas disc or torus. Both scenarios are not mutually exclusive and both can be explained by a recent merger.
Conclusions. J22564–5910 is the first object of its kind. It is a rapidly spinning sdB with gas still present in the system. It is the first post-merger star observed this early after the merger event, and as such it is very valuable system to test merger theories. If the magnetic field can be confirmed, it is not only the first magnetic sdB, but it hosts the strongest magnetic field ever found in a pre-white dwarf object. Thus, it could represent the long sought-after immediate ancestor of strongly magnetic white dwarfs.
Evolution of globular-cluster systems of ultra-diffuse galaxies due to dynamical friction in MOND gravity
Authors: Bílek Michal , Zhao Hongsheng , Famaey Benoit , Müller Oliver , Kroupa Pavel , Ibata Rodrigo 
Published: July 2021

Context. Dynamical friction can be used to distinguish Newtonian gravity and modified Newtonian dynamics (MOND) because it works differently in these frameworks. This concept, however, has yet to be explored very much with MOND. Previous simulations showed weaker dynamical friction during major mergers for MOND than for Newtonian gravity with dark matter. Analytic arguments suggest the opposite for minor mergers. In this work, we verify the analytic predictions for MOND by high-resolution N-body simulations of globular clusters (GCs) moving in isolated ultra-diffuse galaxies (UDGs).
Aims. We test the MOND analog of the Chandrasekhar formula for the dynamical friction proposed by Sánchez-Salcedo on a single GC. We also explore whether MOND allows GC systems of isolated UDGs to survive without sinking into nuclear star clusters.
Methods. The simulations are run using the adaptive-mesh-refinement code Phantom of Ramses. The mass resolution is 20 M⊙ and the spatial resolution 50 pc. The GCs are modeled as point masses.
Results. Simulations including a single GC reveal that, as long as the apocenter of the GC is over about 0.5 effective radii, the Sánchez-Salcedo formula works excellently, with an effective Coulomb logarithm increasing with orbital circularity. Once the GC reaches the central kiloparsec, its sinking virtually stops, likely because of the core stalling mechanism. In simulations with multiple GCs, many of them sink toward the center, but the core stalling effect seems to prevent them from forming a nuclear star cluster. The GC system ends up with a lower velocity dispersion than the stars of the galaxy. By scaling the simulations, we extend these results to most UDG parameters, as long as these UDGs are not external-field dominated. We verify analytically that approximating the GCs by point masses has little effect if the GCs have the usual properties, but for massive GCs such as those observed in the NGC 1052-DF2 galaxy, further simulations with resolved GCs are desirable.