bluuebunny/crossref_metadata_2025_split huggingface dataset:
Venous ligation versus venous repair: does the procedure impact venous thromboembolism risk?
Authors: Farrell Michael Steven , Knudson M Margaret , Stein Deborah M 
Published: March 2021

BackgroundTraumatic lower extremity venous injuries are most commonly managed with either a vein ligation or repair procedure. Venous injuries are associated with an increased risk of developing venous thromboembolisms (VTE), but little is understood with regard to how specific surgical treatments may impact the risk of developing either a deep vein thrombosis (DVT) or a pulmonary embolism (PE). In this study of lower extremity venous injuries, we hypothesized that venous ligation would be associated with an increased risk of DVT but a lower risk of PE when compared with venous repair.MethodsPatients were identified from the National Trauma Data Bank (2008 to 2014) with at least one iliac, femoral, popliteal, or tibial venous injury and who received either a vein ligation or repair. The patients were then compared based on the type of procedure and the location of the injury to assess the risk of DVT and PE between the groups.ResultsA total of 1214 patients were identified. There was no difference between patients who received a vein ligation versus a repair with respect to age, injury severity score, or initial systolic blood pressure. There was no difference in the odds of developing either a DVT or PE between patients who were treated with vein ligation versus repair. There was also no difference in VTE rates when stratified by the location of the injury.ConclusionsIn individuals with lower extremity venous injuries, there is no difference in the rate of DVT or PE complications when comparing venous repair and ligation procedures. The role of anticoagulation remains to be elucidated following operative treatment.Level of evidenceTherapeutic/Care Management, Level IV.
Do more mature preterm babies with surgical necrotizing enterocolitis predominantly develop the colonic disease?
Authors: Sinha Chandrasen K , Ashworth Iona , Martin Sarah , Bhayat Sadaf , Kulkarni Anay 
Published: March 2021

BackgroundThe primary aim was to scrutinize our hypothesis: “Do more mature preterm (MMP) babies with surgical necrotizing enterocolitis (NEC) predominantly develop the colonic disease and are different in their response and behaviour in comparison to exceedingly preterm (EP) babies?” Secondary outcomes were to define time taken in developing NEC, time from diagnosis to laparotomy, requirement of parenteral nutrition (PN), and ventilatory support.MethodsWe defined MMP babies as ≥30 weeks of gestation and EP babies as ≤29 weeks+6 daysof gestation. Inclusion criteria were all babies <37 weeks with NEC requiring surgery (called surgical NEC group). Data were collected retrospectively and analyzed using QuickCalcs.ResultsOf the total, 41% (97/234) of babies underwent laparotomy between 2010 and 2019. Totally, 81% were EP and 19% were MMP babies. Pure colonic involvement was seen in 9% of EP babies in comparison to 56% in the MMP babies (p=0.0001). Involvement of only the small bowel was seen in two-thirds of EP babies in comparison to only one-third in MMP babies (p=0.01). EP cohort required PN for 82 days (median) in comparison to 17 days (median) in the MMP cohort (p=0.001). Ventilation requirement in the EP group versus the MMP group was 24 vs 9 days (median), respectively (p=0.0006).ConclusionsMMP babies predominantly developed colonic disease, whereas EP babies predominantly developed small bowel disease. EP babies required a longer duration of PN and ventilation support. This study opens a new area of research to differentiate pathogenesis and maturation patterns of the small and large bowels in babies with NEC.
Interspecific variation in heat tolerance and evaporative cooling capacity among sympatric temperate-latitude bats
Authors: Noakes Matthew J. , McKechnie Andrew E. , Brigham R. Mark 
Published: March 2021

We tested the hypothesis that interspecific variation in chiropteran heat tolerance and evaporative cooling capacity is correlated with day-roost microclimates, using three vespertilionid bats that occur sympatrically during summer in Saskatchewan, Canada. We predicted that hoary bats (Lasiurus cinereus (Palisot de Beauvois, 1796); ∼22 g) would have higher heat tolerance than little brown bats (Myotis lucifugus (Le Conte, 1831); ∼7 g) and silver-haired bats (Lasionycteris noctivagans (Le Conte, 1831); ∼13 g), as the latter two species roost in tree crevices or cavities that are more thermally buffered than the foliage roosts of hoary bats. We measured core body temperature (Tb; passive integrated transponder tags), evaporative water loss, and resting metabolic rate (flow-through respirometry) while exposing individuals to a stepped profile of increasing air temperature (Ta) from ∼30 °C in ∼2 °C increments. Experiments were terminated when individuals became hyperthermic (Tb ≈ 42.5 °C), with maximum Ta (Ta,max) ranging from 42.0 to 49.7 °C. As predicted, hoary bats had the highest heat tolerance and evaporative cooling capacity, reaching Ta,max ∼2.4 and 1.2 °C higher than little brown and silver-haired bats, respectively. Our results are consistent with the hypothesis that heat tolerance of bats is correlated with roost microclimates, although interspecific variation in body mass and phylogeny may confound these conclusions.
Acceptability conditions and relativistic barotropic equations of state
Authors: Hernández Héctor , Suárez-Urango Daniel , Núñez Luis A. 
Published: March 2021

AbstractWe sketch an algorithm to generate exact anisotropic solutions starting from a barotropic EoS and setting an ansatz on the metric functions. To illustrate the method, we use a generalization of the polytropic equation of state consisting of a combination of a polytrope plus a linear term. Based on this generalization, we develop two models which are not deprived of physical meaning as well as fulfilling the stringent criteria of physical acceptability conditions. We also show that some relativistic anisotropic polytropic models may have singular tangential sound velocity for polytropic indexes greater than one. This happens in anisotropic matter configurations when the polytropic equation of state is implemented together with an ansatz on the metric functions. The generalized polytropic equation of state is free from this pathology in the tangential sound velocity.
Volar RIM Plate Rarely Causes Flexor Tendon Complications in a Short Period Despite Its Plate Prominence over the Watershed Line: A Descriptive Study
Authors: Hayakawa Kazuo , Okamoto Hideki , Kojima Taiki , Fukuoka Muneyoshi , Murakami Hideki 
Published: March 2021

Background: The DePuy Synthes variable angle LCP® Volar RIM Plate has been designed with its contour to overhang volar rim fragments of the distal radius to prevent secondary displacement after fracture fixation. Therefore, RIM potentially contributes to a risk of flexor tendon rupture due to its plate prominence over the watershed line. This is a retrospective cross-sectional study that aims at describing the occurrence of complications by utilizing RIM as well as three standards VLPs to evaluate the impact of plate design on flexor tendons. Methods: A total of 84 patients with a volar locking plate fixation were analyzed retrospectively (Far-distal; RIM: 14 cases, Juxta-articular; AcuLoc2 (ACUMED): 20 cases, Dual-Loc V7 (MEIRA): 25 cases, Extra-articular; VA-TCP (DePuy Synthes): 25 cases). Tendinous problems were evaluated with a reported adverse event and flexor tendon appearance examined by utilizing ultrasonography and direct observation during hardware removal. Plate prominence was graded according to Soong’s classification and the distance to flexor tendons was measured to describe the risk that each plate damage the flexor tendons. Results: The mean follow-up period was 13.0 months. All RIM plates were placed in grade 2 (85.7%) and grade 1 (14.3%). Symptomatic and asymptomatic tendinous problems were barely reported in RIM. The examination of ultrasonography and direct observation during hardware removal showed that tendons smoothly slid without attrition on the curved plate surface of RIM despite their adjacent appositions came from its high and distal plate prominence. Conclusions: Smooth profile of RIM showed an ability to decrease the potential risk of flexor tendon damage regardless of its prominence over the watershed line. RIM can be applied more to challenging far distal fractures when used judiciously and surgeons need to be even more vigilant for symptoms of tendon irritation as usually recommended without being coward more than necessary.
Clinical Effectiveness of Dorsal Branch Skin Flap of Proper Palmar Digital Artery with Distal Pedicle in Repairing of Fingertip Soft Tissue Defect: A 1-Year Prospective Study in a Chinese Tertiary Referral Teaching Hospital
Authors: Mendame Ehya Regis Ernest , Bounda Guy-Armel , Xiao Weidong , Yu Aixi , Wen Qibai 
Published: March 2021

Background: Digital island flap remains among the most useful types of providing soft-tissues coverage for defect on the fingertip accompanied with underlying structures exposure. Nevertheless, its trends of functional and aesthetic issues such as the limited length of advancement and the limited flap size are the essential disadvantages. The main objective of the study was to assess the clinical effectiveness of dorsal branch skin flap of proper palmar digital artery with distal pedicle in repairing of fingertip soft tissue defect accompanied with underlying structures exposure. Methods: This is a 1-year prospective study, in which 21 patients (24 fingers) with traumatic fingertip skin and soft tissue defects had undergone emergency repair with dorsal skin flap of proper palmar digital artery with distal pedicle. The starting point of the dorsal proper palmar digital artery which is at the connection of distal interphalangeal joint with the digital midline was selected as the rotation point of the surgical skin flap, with an incision area of 1.1 cm × 1.4 cm–2.7 cm × 2.0 cm, the pedicle of 0.8–1.7 cm and disposition of 90°–120° to cover the fingertip. Results: All flaps had completely healed postoperatively. In 2 cases, tension blisters of the flap and partial necrosis were observed, which survived after change in dressing and rational administration vasodilator medication. Patients were followed up to 6 months. Favorable appearance and function were restored, and satisfactory recovery of the sensory functions of the fingers had been achieved. The two-point discrimination of skin flap with anastomosis of nerve could reach 4.5–9.4 mm (mean, 6.80 mm). Conclusions: Repairing the fingertip skin and soft tissue defect of 2nd–5th finger via primary surgical repair with dorsal distal pedicle or proper palmar digital artery skin flap is a good technique. The high survival rate of the flap, the favorable flap’s appearance, and the satisfactory recovery of the sensory functions of the fingers are among the advantages of this reconstructive technique.
LncRNA SAMMSON Mediates Adaptive Resistance to RAF Inhibition in BRAF-Mutant Melanoma Cells
Authors: Han Shujun , Yan Yuwei , Ren Yibo , Hu Yiming , Wang Yan , Chen Lei , Zhi Zhe , Zheng Yan , Shao Yongping , Liu Jiankang 
Published: March 2021

Abstract

The long noncoding RNA (lncRNA) SAMMSON is required for human melanoma cell growth and survival. However, whether SAMMSON regulates the response of mutant BRAF melanoma cells to RAF inhibitors remains unknown. In this work, we showed that SAMMSON is rapidly induced upon inhibition of ERK signaling, and SAMMSON overexpression conferred resistance to vemurafenib-induced cytotoxicity in melanoma cells. SOX10 mediated transcriptional induction of SAMMSON by vemurafenib, and SOX10 sumoylation at K55 was essential for this function. In addition, depletion of SAMMSON activated p53 signaling, which is dependent on the SAMMSON-interacting protein CARF. Depletion of SAMMSON sensitized mutant BRAF melanoma cells to RAF inhibitors in vitro and in vivo, while CARF knockdown reversed the enhanced sensitivity. In summary, these findings suggest that SAMMSON may function as a new mediator of adaptive resistance to RAF inhibitors in melanoma by modulating CARF-p53 signaling.

Significance:
This study highlights the role of a SAMMSON/CARF/p53 signaling axis in modulating the adaptive resistance of mutant BRAF melanoma to RAF inhibitors.
Prediagnostic Antibody Responses to Fusobacterium nucleatum Proteins Are Not Associated with Risk of Colorectal Cancer in a Large U.S. Consortium
Authors: Lo Chun-Han , Blot William J. , Teras Lauren R. , Visvanathan Kala , Le Marchand Loïc , Haiman Christopher A. , Chen Yu , Sesso Howard D. , Wassertheil-Smoller Sylvia , Tinker Lesley F. , Peek Richard M. , Potter John D. , Cover Timothy L. , Zeleniuch-Jacquotte Anne , Berndt Sonja I. , Waterboer Tim , Epplein Meira , Butt Julia , Song Mingyang 
Published: March 2021

Abstract

Background:
The association between prediagnostic antibody responses to Fusobacterium nucleatum (F. nucleatum) and subsequent risk of colorectal cancer is not established.

Methods:
We conducted a nested case–control study of 8,126 participants in a consortium of 10 prospective cohorts in the United States.

Results:
Higher seroprevalence of any F. nucleatum antibody was observed among non-White participants (51.1%) compared with White participants (31.2%). We did not find any statistically significant association between seropositivity to any of the eight F. nucleatum proteins and colorectal cancer risk.

Conclusions:
Prediagnostic antibody responses to F. nucleatum proteins were not associated with the risk of colorectal cancer.

Impact:
Future studies may consider a more specific detection of the immunoglobulin isotypes or focus on examining F. nucleatum in stool or tissue samples.
A Data Collection on Secondary School Students' STEM
Performance and Reading Practices in an Emerging Country
Authors: Vuong Quan-Hoang , La Viet-Phuong , Ho Manh-Toan , Pham Thanh-Hang , Vuong Thu-Trang , Vuong Ha-My , Nguyen Minh-Hoang 
Published: March 2021

Abstract
Science, technology, engineering, and mathematics (STEM) education has become a critical factor in promoting sustainable development. Meanwhile, book reading is still an essential method for cognitive development and knowledge acquisition. In developing countries where STEM teaching and learning resources are limited, book reading is an important educational tool to promote STEM. Nevertheless, public data sets about STEM education and book reading behaviors in emerging countries are scarce. This article, therefore, aims to present a data set of 4,966 secondary school students from a school-based data collection in Vietnam. The data set comprises of five major categories: 1) students' personal information (including STEM performance), 2) family-related information, 3) book reading preferences, 4) book reading frequency/habits, and 5) classroom activities. By introducing the designing principles, the data collection method, and the variables in the data set, we aim to provide researchers, policymakers, and educators with well-validated resources and guidelines to conduct low-cost research, pedagogical programs in emerging countries.
Distractors Selectively Modulate Electrophysiological Markers of Perceptual Decisions
Authors: Zhou Shou-Han , Loughnane Gerard , O'Connell Redmond , Bellgrove Mark A. , Chong Trevor T.-J. 
Published: March 2021

Abstract
Current models of perceptual decision-making assume that choices are made after evidence in favor of an alternative accumulates to a given threshold. This process has recently been revealed in human EEG recordings, but an unresolved issue is how these neural mechanisms are modulated by competing, yet task-irrelevant, stimuli. In this study, we tested 20 healthy participants on a motion direction discrimination task. Participants monitored two patches of random dot motion simultaneously presented on either side of fixation for periodic changes in an upward or downward motion, which could occur equiprobably in either patch. On a random 50% of trials, these periods of coherent vertical motion were accompanied by simultaneous task-irrelevant, horizontal motion in the contralateral patch. Our data showed that these distractors selectively increased the amplitude of early target selection responses over scalp sites contralateral to the distractor stimulus, without impacting on responses ipsilateral to the distractor. Importantly, this modulation mediated a decrement in the subsequent buildup rate of a neural signature of evidence accumulation and accounted for a slowing of RTs. These data offer new insights into the functional interactions between target selection and evidence accumulation signals, and their susceptibility to task-irrelevant distractors. More broadly, these data neurally inform future models of perceptual decision-making by highlighting the influence of early processing of competing stimuli on the accumulation of perceptual evidence.
Ensemble Statistics Can Be Available before Individual Item Properties: Electroencephalography Evidence Using the Oddball Paradigm
Authors: Epstein Michael L. , Emmanouil Tatiana A. 
Published: March 2021

Abstract
Behavioral studies have shown that statistical properties of object groups are perceived accurately with brief exposure durations. This finding motivated the hypothesis that ensemble perception occurs rapidly in vision. However, the precise timing of ensemble perception remains unclear. Here, we used the superior temporal resolution of electroencephalography to directly compare the timing of ensemble processing to that of individual object processing. The P3b was chosen as a particular component of interest, as it is thought to measure the latency of stimulus evaluation. Participants performed a simple “oddball” task in which sets of 51 lines with varied orientations sequentially flashed briefly on the display. In these sequences, there was a 20% chance of an individual oddball, wherein one marked object tilted clockwise, and a 20% chance of an ensemble oddball, wherein the average orientation of the set tilted clockwise. In counterbalanced blocks, participants were instructed to respond to either individual or ensemble oddballs. ERP analysis was performed to test the timing of this processing. At parietal electrodes, P3b components were found for both individual and ensemble oddballs. Ensemble P3b components were found to occur significantly earlier than individual P3b components, as measured with both 50% area latency and 50% onset latency. Using multivariate pattern analysis, ensemble oddball trials were classifiable from standard trials significantly earlier in their timecourse than individual oddball trials. Altogether, these results provide compelling evidence that ensemble perception occurs rapidly and that ensemble properties can be available earlier than individual object properties.
Patients with Ventromedial Prefrontal Lesions Show an Implicit Approach Bias to Angry Faces
Authors: Buades-Rotger Macià , Solbakk Anne-Kristin , Liebrand Matthias , Endestad Tor , Funderud Ingrid , Siegwardt Paul , Enter Dorien , Roelofs Karin , Krämer Ulrike M. 
Published: March 2021

Abstract
Damage to the ventromedial PFC (VMPFC) can cause maladaptive social behavior, but the cognitive processes underlying these behavioral changes are still uncertain. Here, we tested whether patients with acquired VMPFC lesions show altered approach–avoidance tendencies to emotional facial expressions. Thirteen patients with focal VMPFC lesions and 31 age- and gender-matched healthy controls performed an implicit approach–avoidance task in which they either pushed or pulled a joystick depending on stimulus color. Whereas controls avoided angry faces, VMPFC patients displayed an incongruent response pattern characterized by both increased approach and reduced avoidance of angry facial expressions. The approach bias was stronger in patients with higher self-reported impulsivity and disinhibition and in those with larger lesions. We further used linear ballistic accumulator modeling to investigate latent parameters underlying approach–avoidance decisions. Controls displayed negative drift rates when approaching angry faces, whereas VMPFC lesions abolished this pattern. In addition, VMPFC patients had weaker response drifts than controls during avoidance. Finally, patients showed reduced drift rate variability and shorter nondecision times, indicating impulsive and rigid decision-making. Our findings thus suggest that VMPFC damage alters the pace of evidence accumulation in response to social signals, eliminating a default, protective avoidant bias and facilitating a dysfunctional approach behavior.
Deep Predictive Learning in Neocortex and Pulvinar
Authors: O'Reilly Randall C. , Russin Jacob L. , Zolfaghar Maryam , Rohrlich John 
Published: March 2021

AbstractHow do humans learn from raw sensory experience? Throughout life, but most obviously in infancy, we learn without explicit instruction. We propose a detailed biological mechanism for the widely embraced idea that learning is driven by the differences between predictions and actual outcomes (i.e., predictive error-driven learning). Specifically, numerous weak projections into the pulvinar nucleus of the thalamus generate top–down predictions, and sparse driver inputs from lower areas supply the actual outcome, originating in Layer 5 intrinsic bursting neurons. Thus, the outcome representation is only briefly activated, roughly every 100 msec (i.e., 10 Hz, alpha), resulting in a temporal difference error signal, which drives local synaptic changes throughout the neocortex. This results in a biologically plausible form of error backpropagation learning. We implemented these mechanisms in a large-scale model of the visual system and found that the simulated inferotemporal pathway learns to systematically categorize 3-D objects according to invariant shape properties, based solely on predictive learning from raw visual inputs. These categories match human judgments on the same stimuli and are consistent with neural representations in inferotemporal cortex in primates.
Inferring the causal effect of journals on citations
Authors: Traag V. A. 
Published: March 2021

AbstractArticles in high-impact journals are, on average, more frequently cited. But are they cited more often because those articles are somehow more “citable”? Or are they cited more often simply because they are published in a high-impact journal? Although some evidence suggests the latter, the causal relationship is not clear. We here compare citations of preprints to citations of the published version to uncover the causal mechanism. We build on an earlier model of citation dynamics to infer the causal effect of journals on citations. We find that high-impact journals select articles that tend to attract more citations. At the same time, we find that high-impact journals augment the citation rate of published articles. Our results yield a deeper understanding of the role of journals in the research system. The use of journal metrics in research evaluation has been increasingly criticized in recent years and article-level citations are sometimes suggested as an alternative. Our results show that removing impact factors from evaluation does not negate the influence of journals. This insight has important implications for changing practices of research evaluation.