bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of Mycophenolic Acid Exposure in Heart Transplant Recipients by Population Pharmacokinetic and Limited Sampling Strategies
Authors: Wang Xipei , Wu Yijin , Huang Jinsong , Shan Songgui , Mai Mingjie , Zhu Jiade , Yang Min , Shang Dewei , Wu Zheng , Lan Jinhua , Zhong Shilong , Wu Min 
Published: November 2021

Purpose: The aim of this study is i) to establish a strategy to estimate the area under the curve of the dosing interval (AUC0–12h) of mycophenolic acid (MPA) in the heart transplant recipients and ii) to find the covariates that significantly affect the pharmacokinetics of MPA exposure.Methods: This single-center, prospective, open-label, observational study was conducted in 91 adult heart transplant recipients orally taking mycophenolate mofetil dispersible tablets. Samples collected intensively and sparsely were analyzed by the enzyme-multiplied immunoassay technique, and all the data were used in PPK modeling. Potential covariates were tested stepwise. The goodness-of-fit plots, the normalized prediction distribution error, and prediction-corrected visual predictive check were used for model evaluation. Optimal sampling times by ED-optimal strategy and multilinear regression (MLR) were analyzed based on the simulated data by the final PPK model. Moreover, using intensive data from 14 patients, the accuracy of AUC0–12h estimation was evaluated by Passing–Bablok regression analysis and Bland–Alman plots for both the PPK model and MLR equation.Results: A two-compartment model with first-order absorption and elimination with a lag time was chosen as the structure model. Co-medication of proton pump inhibitors (PPIs), estimated glomerular filtration rate (eGFR), and albumin (ALB) were found to significantly affect bioavailability (F), clearance of central compartment (CL/F), and the distribution volume of the central compartment (V2/F), respectively. Co-medication of PPIs decreased F by 27.6%. When eGFR decreased by 30 ml/min/1.73 m2, CL/F decreased by 23.7%. However, the impact of ALB on V2/F was limited to MPA exposure. The final model showed an adequate fitness of the data. The optimal sampling design was pre-dose and 1 and 4 h post-dose for pharmacokinetic estimation. The best-fit linear equation was finally established as follows: AUC0–12h = 3.539 × C0 + 0.288 × C0.5 + 1.349 × C1 + 6.773 × C4.5.Conclusion: A PPK model was established with three covariates in heart transplant patients. Co-medication of PPIs and eGFR had a remarkable impact on AUC0–12h of MPA. A linear equation was also concluded with four time points as an alternative way to estimate AUC0–12h for MPA.
Metabolomic Characterization of Fatty Acids in Patients With Coronary Artery Ectasias
Authors: Liu Tianlong , Sun Yingying , Li Hao , Xu Haochen , Xiao Ning , Wang Xuliang , Song Li , Bai Congxia , Wen Hongyan , Ge Jing , Zhang Yinhui , Song Weihua , Chen Jingzhou 
Published: November 2021

Background: We used a targeted metabolomics approach to identify fatty acid (FA) metabolites that distinguished patients with coronary artery ectasia (CAE) from healthy Controls and patients with coronary artery disease (CAD).Materials and methods: Two hundred fifty-two human subjects were enrolled in our study, such as patients with CAE, patients with CAD, and Controls. All the subjects were diagnosed by coronary angiography. Plasma metabolomic profiles of FAs were determined by an ultra-high-performance liquid chromatography coupled to triple quadrupole mass spectrometric (UPLC-QqQ-MS/MS).Results: Ninety-nine plasma metabolites were profiled in the discovery sets (n = 72), such as 35 metabolites of arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), 10 FAs, and 54 phospholipids. Among these metabolites, 36 metabolites of AA, EPA, and DHA showed the largest difference between CAE and Controls or CAD. 12-hydroxyeicosatetraenoic acid (12-HETE), 17(S)-hydroxydocosahexaenoic acid (17-HDoHE), EPA, AA, and 5-HETE were defined as a biomarker panel in peripheral blood to distinguish CAE from CAD and Controls in a discovery set (n = 72) and a validation set (n = 180). This biomarker panel had a better diagnostic performance than metabolite alone in differentiating CAE from Controls and CAD. The areas under the ROC curve of the biomarker panel were 0.991 and 0.836 for CAE versus Controls and 1.00 and 0.904 for CAE versus CAD in the discovery and validation sets, respectively.Conclusions: Our findings revealed that the metabolic profiles of FAs in the plasma from patients with CAE can be distinguished from those of Controls and CAD. Differences in FAs metabolites may help to interpret pathological mechanisms of CAE.
Prison Unhealthy Lifestyle and Poor Mental Health of Older Persons—A Qualitative Study
Authors: Pageau Félix , Cornaz Corinne Devaud , Gothuey Isabelle , Seaward Helene , Wangmo Tenzin , Elger Bernice S. 
Published: November 2021

Background: Mental healthcare and lifestyle habits in prison, especially for older individuals, has been shown to be suboptimal. Most psychiatric conditions left untreated worsen food choices, physical inactivity, and substance abuse. In turn, bad habits lead to poorer mental health.Methods: To comprehensively illustrate this downward spiraling, we completed a thorough analysis of data obtained through semi-structured qualitative interviews. There were 50 interviews of aging incarcerated people included in this article. They were analyzed following a classical six-stepped thematic analysis.Results: According to our participants, sports are not well-adapted to aging individuals, nor to people with medical conditions. Prison is even more unadapted for those who both are aging and have medical conditions. Also, food served is less than optimal. According to our interviews, the older imprisoned individual often does not have access to food adapted to his or her medical conditions. Sport is maladapted for older incarcerated individuals and mostly tailored for younger ones. Finally, boredom and lack of responsibility hinder change toward a better lifestyle for older adults in prison.Conclusion: Our paper shows why prison environmental modifications are needed to help older adults with their lifestyle habits. It also exposes an original way to see the relationship between mental health and lifestyle habits.
Intervertebral Foramen Width Is an Important Factor in Deciding Additional Uncinate Process Resection in ACDF—a Retrospective Study
Authors: Sun Baifeng , Xu Chen , Zhang Yizhi , Wu Shenshen , Wu Huiqiao , Zhang Hao , Shen Xiaolong , Zhang Zifan , Yuan Wen , Liu Yang 
Published: November 2021

Background: Anterior cervical discectomy and fusion (ACDF) has been established as a classic procedure for the management of cervical radiculopathy. However, it is unclear whether combined uncinate process resection (UPR) is necessary for treating cervical radiculopathy. Here, we investigated the clinical outcome of ACDF combined with UPR compared to ACDF alone to determine the necessity of UPR in treating cervical radiculopathy.Hypothesis: Uncinate process resection may be necessary in certain patients along with ACDF to achieve better clinical outcomes of cervical radiculopathy.Patients and Methods: Fifty-five patients underwent ACDF with UPR, and 126 patients without UPR were reviewed. The width and height of the intervertebral foramen were measured by 45° oblique X-rays. We also measured the Japanese Orthopedic Association (JOA) score and visual analog scale (VAS) score. C2–C7 Cobb angles were obtained from all patients pre- and post-operatively. Meanwhile, linear regression analysis was used to evaluate the relationship between the clinical outcomes and the intervertebral foramen width before surgery.Results: Linear regression analysis indicated that the improvement in the JOA and VAS scores was irrelevant to both the pre-operative width of the intervertebral foramen (wIVF) and the height of the intervertebral foramen (hIVF) in the ACDF+UPR group. However, pre-operative wIVF was associated with post-operative JOA and VAS scores in the ACDF alone group. Those with pre-operative wIVF &lt;3 mm in the ACDF group had the least improvement in post-operative clinical symptoms due to the change in wIVF (P &gt; 0.05). The ACDF group whose wIVF was over 3 mm showed similar clinical outcomes to the ACDF + UPR group, and wIVF significantly increased post-operatively (P &lt; 0.05). The fusion rate and C2–C7 Cobb angles did not show significant differences between the two groups (P &gt; 0.05).Discussion: Our current findings suggest that UPR should be considered when wIVF is &lt;3 mm pre-operatively. However, there is no need to sacrifice the uncovertebral joint in ACDF when the pre-operative wIVF is over 3 mm.Level of Evidence: Level III.
PRAXEOLOGICAL PARAMETERS OF IDENTIFICATION AND SOLUTION OF CONTROL TASKS OF ENTERPRISES TRANSACTIONS WITH REAL ESTATE
Authors: SHERSTIUK Oleksandr 
Published: November 2021

The subject of the study is the implementation control measures operations of entitie's real estate. The purpose of the article is to identify the tasks of real estate transactions control. The basis of the research methodology is the application of a systematic approach, methods of analysis, synthesis, bibliographic research and modeling. The main types of real estate transactions of business entities are identified. It is proposed to identify the tasks of their control on the basis of the functions performed by the management system. It is istablished that the content of control tasks when planning real estate transactions is determined according to the expectations of stakeholders regarding future events and their results. The necessity to formalize the relevant tasks to determine their compliance with the interests of the business entity and persons interested in information about its activities is proved. It is grounded that during the formation and implementation of management decisions the real estate control tasks have to include the possibility of ensuring their compliance with economic, social and other interests of stakeholders according to determination their acceptability in terms of consistency with formalized algorithms. The control tasks solving at the stage of assessing of the implementation status of the management decisions involves determining the operations results of the controlled entity with real estate on the basis of the received information. At the stage of real estate transactions regulation the tasks of control should be to establish the grounds for management decisions making adjustments to the activity. The formulated tasks of control of real estate transactions of entities provide an opportunity to determine the target direction of measures, as a result of which stakeholders will be able to adequately assess their content, quality characteristics and results. Solving the control tasks identified during the study will help meet the needs of stakeholders in the necessary information, optimize the organizational, informational and methodical support of control.
A commentary on: Reappropriation of Gendered Irish Sign Language in One Family
Authors: Dyson Mary 
Published: November 2021

Barbara LeMaster’s article “Reappropriation of Gendered Irish Sign Language in One Family” in Visual Anthropology Review piqued my interest with its initial sentence:
The native vocabularies of one segment of the Dublin deaf community (i.e., primarily women over 70 and men over 55) contain different signs for the majority of common lexical items examined (LeMaster 1990).
From this I learned that there existed different female and male signs in Irish Sign Language. This intrigued me and led me to explore further, despite recognizing that I was probably out of my comfort zone. I would be addressing a topic of social history, through my lens of theoretical and empirical aspects of communication design. Curiously, I rejected a more comfortable choice of an article that uses an approach far more familiar to me: research analyzing the covers of introductory texts on cultural anthropology (Hammond et al., 2009). I am therefore acutely aware that the questions I ask about Irish Sign Language not only stem from another discipline, but also introduce different research methods. I also suspect that some of the issues I raise are covered elsewhere, either by LeMaster or by other researchers. This I regard as a positive sign of considerable overlap between our disciplines.
In the following commentary on LeMaster’s article, I start with a brief account of what I consider to be main themes within the article. This is not a comprehensive summary, but sets the scene for discussion points. I then propose some general differences in approach and emphasis between the disciplines of visual anthropology, as represented in this article, and communication design. Although I have situated myself within a particular sector of communication design (in the introduction), I have nonetheless tried to cover a wider field encompassing design practitioners and historians. From more general topics, I narrow down to specific areas that might inform, or be informed by, graphic communication research: the process of language standardization and dictionary design. The final section on signs moves us some distance from LeMaster’s study. However, personally, one of the most exciting aspects of research is forging links between apparently disparate areas of research, which might require a leap in the dark.
SIGNIFIKANSI PERDAGANGAN DAN UANG SEBAGAI MEDIA TRANSAKSI DALAM KONTEKS KEBIJAKAN MONETER PADA MASA SEBELUM DAN AWAL PEMERINTAHAN ISLAM
Authors: Jamil Irpan 
Published: November 2021

ABSTRAKPermasalahan ekonomi yang di hadapi umat manusia sama tuanya dengan usia keberadaan manusia di muka bumi ini. Masalah utama dalam penelitian ini adalah kebijakan moneter seperti apa yang diterapkan pada masa sebelum dan awal pemerintahan Islam kaitannya dengan perdagangan dan uang sebagai aktivitas dan media transaksi pada saat itu.Tujuan penelitian ini adalah untuk menganalisis signifikansi perdagangan dan uang sebagai media transaksi yang dipakai serta kondisi yang melatarbelakanginya dan dinamika yang tejadi pada saat itu. Metode yang digunakan dalam penelitian ini yaitu metode analisis deskriftif dengan pendekatan aspek historis. Hasil dan temuan dalam penelitian ini menunjukkan bahwa hubungan internasional perdagangan mempunyai peran yang strategis terutama dengan dijadikannya Mekkah sebagai pusat perdaganga internasional. Temuan dalam penelitian ini juga menunjukkan bahwa produk, mata uang yang digunakan cukup memberikan kejelasan bahwa Mekkah sudah menjadi tempat “perbankan”ABSTRACKThe economic problems faced by mankind are as old as the age of human existence on this earth. The main problem in this study is what kind of monetary policy was applied in the period before and the beginning of Islamic rule in relation to trade and money as an activity and transaction medium at that time. behind it and the dynamics that occurred at that time. The method used in this research is descriptive analysis method with historical aspect approach. The results and findings in this study indicate that international trade relations have a strategic role, especially by making Mecca a center for international trade. The findings in this study also show that the product, the currency used is sufficient to provide clarity that Mecca has become a place of "banking".
STRATEGI PENGEMBANGAN PASAR MODAL SYARIAH DI INDONESIA
Authors: Jayengsari Reksa , Muthmainnah Muthmainnah , Hernawati Euis 
Published: November 2021

AbstrakPenelitian ini bertujuan untuk menganalisis masalah yang selanjutnya menjadi langkah strategis berupa rencana tindak lanjut pengembangan pasar modal syariah yang dari tahun ke tahun mengalami peningkatan. Metode penelitian yang digunakan adalah studi literatur yang berdasarkan pada jurnal-jurnal. Pengumpulan data dilakukan melalui Focus Group Discussion (FGD). Selanjutnya data yang telah terkumpul dianalisis dengan menggunakan analisis Urgency, Seriousness, dan Growth (USG). Berdasarkan analisis USG diperoleh masalah-masalah yang terjadi yang dapat menghambat pengembangan pasar modal syariah di Indonesia. Permasalahan yang difokuskan diantaranya sistem ekonomi yang belum menunjang, kurangnya pengetahuan produk investasi di pasar modal syariah, persepsi masyarakat kurang memadai karena kurangnya literasi, trust issues terhadap produk syariah dan minimnya regulasi. Dari permasalahan tersebut dibuatkan rencana tindak kerja sebagai solusi yang akhirnya dijadikan strategi pengembangan pasar modal syariah di Indonesia. Diagram fishbone digunakan untuk mengetahui strategi dalam optimalisasi pengembangan pasar modal syariah yang berawal dari masalah perkembangan pasar modal syariah di Indonesia. Pada diagram fishbone menunjukan permasalahan yang menjadi acuan dalam strategi pengembangan pasar modal syariah di IndonesiaAbstractThis study aims to analyze the problem which then becomes a strategic step in the form of a follow-up plan for the development of the Islamic capital market which has increased from year to year. The research method used is a literature study based on journals. Data collection through Focus Group Discussion (FGD). And then, the data that has been collected was analyzed using the analysis of Urgency, Seriousness, and Growth (USG). Based on the USG analysis, the results of the problems that occur that can hinder the development of the Islamic capital market in Indonesia are obtained. The problems that are focused on include an unsupported economic system, lack of knowledge of investment products in the Islamic capital market, inadequate public perception due to lack of literacy, trust issues on sharia products and lack of regulation. From these problems, a work action plan was made as a solution which eventually became a strategy for developing the Islamic capital market in Indonesia. The fishbone diagram is used to determine the strategy in optimizing the development of the Islamic capital market which started from the problem of the development of the Islamic capital market in Indonesia. The fishbone diagram shows the problems that become a reference in the strategy for developing the Islamic capital market in Indonesia.
Muslim Historical Literature in the Era of Early Muslim Nationalism
Authors: Malik Salahuddin 
Published: November 2021

Mid-nineteenth century Muslim historical literature, particularly onthe mutiny-rebellion of 1857, presents an interesting contrast, and offersa fascinating study of the state of Muslim mind before and after 1857.This clearly comes out in the writings of Sir Sayyid Ahmad Khan(Risalah Asbab-i Baghawat-i Hind,‘ Tarikh Sarkashi Dil ’a Bijnawr,Hunter par Hunter, Loyal Mohammedans of India,), FatehMuhammad Ta’ib (Tarikh-i Ahmadi), Asad Ullah Khan Ghalib(Dastabu in Kulliyat-i Nathr-i Ghalib), Mawlana Altaf Hussain Hali(Hayati-i Jawid), Sayyid Zahiruddin Zahir Dihlawi (Dastan-i Ghadr),Faqir Muhammad (Jam’ al-Tawarikh), Allamah Fadl-i Haq (BughiHindwtan), Mu’inuddin Hassan Khan (“Narrative of Mainodin” inCharles T. Metcalfe’s Two Native Narratives of the Mutiny in Delhi).”Curiously, all of the above writers presented different interpretationsof the revolt of 1857. Indeed this had to be the case. During the revoltIndia lost freedom of the press; known different interpretations of the“mutiny” by natives were tantamout to treason and were visited bycondign punishments. This was particularly true of the Muslims. ManyMuslim newspapers were suppressed and their editors jailed. After the“special” treatment which the Muslims received upon the fall of Delhi,the followers of Islam could not be sure of their destiny in South Asia inthe post mutiny-rebellion period. It was so because the British assignedthe primary responsibility for the revolt to Indian Muslims and rightlyso. The reality of the excessively harsh British treatment of IndianMuslims is beginning to dawn upon the present-day British historians aswell. Professor Peter Hardy in his very recent book, The Muslims ofBritish India, observes: ...
Guiding Light
Authors: AbuSulayman 'AbdulHamid A. 
Published: November 2021

TranslationIn the name of Allah, most benevolent, ever-merciful.
19. Truly man was created Very impatient;20. Fretful when evilTouches him;Good reaches him;22. Not so those decotedTo prayer;23. Those who remain steadfastTo their prayer;24. And those in whose wealthIs a recognised right;25. For the (needy) who asksAnd him who is prevented(For some reason from asking);26. And those who holdTo the truth of theDay Of Judgment;27. And those who fearThe displeasure of their Lord, . . .29. And those who guardTheir chasity, . . . ;32. And those who respectTheir trusts and covenants;33. And those who stand firmIn their testimonies;34. And those who guard(The sacredness) of their worship;35. Such will beThe honoured onesIn the Gardens (of Bliss). Surah LXX.For behavioral scientists, especially psychologists and psychiatrists, mostof whom these days are preoccupied with wide-spread psychological anxietiesand suicidal behavior, the Qur'an in this part of Surah al Ma'arij proposescertain traits and qualities of man which counter human fears and anxieties.It is the duty of Muslim behavioral scientists in general and psychiatrists inparticular to study and research these Qur'anic directions and propositionsabout human nature, and the traits, habits and behaviors necessary to countertheir negative effects on human life, peace and mind and gratification. It istheir duty to make people understand the important role of these Qur'anic directionsin human life and suggest the ways and means to the Muslims to develop ...