bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the Use of Trauma‐Informed Mental Health Assessment Measures in Care Planning for Children and Adolescents in Out‐of‐Home Residential Care in Singapore
Authors: Peh Chao‐Xu , Tan Jackson , Lei Tracy , Wong Eunice , Henn‐Haase Clare Marie 
Published: December 2021

Children and young people (CYP) within the Child Welfare System (CWS) often experience a range of trauma‐related difficulties. However, systematic use of evidence‐based measures to support mental health assessment and care planning appeared to be lacking within CWS in Singapore. This study evaluated the use of evidence‐based measures to inform care planning in out‐of‐home residential care in Singapore. Participants were 65 CYP in care. Measures consisted of the Child PTSD Symptom Scale for DSM‐5 (CPSS‐5), Assessment Checklist for Children (ACC) and Adolescents (ACA), Child Behavior Checklist (CBCL) and Youth Self‐Report (YSR). Care plans were identified based on the measures' clinical criteria and validated against the Child and Adolescent Needs and Strengths (CANS) and Adverse Childhood Experience (ACE) questionnaire. More intensive measurement‐based care plans were associated with higher service needs and lower strengths on the CANS, and higher ACE exposure. However, there was limited support for the validity of care plans when evaluated against the CANS and ACE questionnaire. Methodological implications for mental health assessment are discussed. Compared to service‐allocation‐as‐usual, measurement‐based care plans identified more cases that may require intensive psychological intervention. Overall, study findings provided some support for the use of assessment measures to supplement care planning in residential care.‘This study evaluated the use of evidence‐based measures to inform care planning in out‐of‐home residential care in Singapore’Key Practitioner Messages

A comprehensive approach to care planning for CYP in out‐of‐home residential care should include the use of multi‐informant evidence‐based mental health assessment measures.
The use of mental health assessment measures may reduce information gaps and complement the use of service needs assessment tools.
Measurement‐based care planning may provide added value to supplement existing standard psychological care planning practices in out‐of‐home residential care.
Clinically suspected myocarditis in COVID‐19 patients: Case series and review of the literature
Authors: Amin Ahmad , Eftekhar Seyed Parsa , Ziaie Naghmeh , Roudbari Soudeh , Salehi Pegah , Jalali Farzad , Jafaripour Iraj , Ghaffari Sanaz , Mohseni Salehi Maryam , Ebadi Reza 
Published: December 2021

AbstractThis Study describes eleven patients positive for severe acute respiratory syndrome coronavirus 2. In our cases, females and younger patients developed more severe disease. In contrast, improvement in left ventricular ejection fraction and N‐terminal prohormone brain natriuretic peptide within the first week of treatment contributed to promising outcomes.
Validation of diagnostic and predictive biomarkers for hereditary angioedema via plasma N‐glycomics
Authors: Zhang Zejian , Wang Xue , Gu Jianqing , Wu Jianqiang , Cao Yang , Xu Yingyang , Li Lisha , Guan Kai , Liu Peng , Yin Jia , Zhi Yuxiang , Zhang Shuyang 
Published: December 2021

AbstractBackgroundHereditary angioedema (HAE) is a rare disease with heterogeneous clinical symptoms. It is vitally important to predict whether an HAE patient will develop severe symptoms in clinical practice, but there are currently no predictive biomarkers for HAE stratification. Plasma N‐glycomes are disease‐specific and have great potential for the discovery of non‐invasive biomarkers. In this study, we profiled the plasma N‐glycome of HAE patients from two independent cohorts to identify candidate biomarkers.MethodsLinkage‐specific sialylation derivatization combined with matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry detection and automated data processing was employed to analyze the plasma N‐glycome of two independent type‐1 HAE cohorts.ResultsHAE patients had abnormal glycan complexity, galactosylation, and α2,3‐ and α2,6‐linked sialylation compared to healthy controls (HC). The classification models based on dysregulated glycan traits could successfully discriminate between HAE and HC with area under the curves (AUCs) being greater than 0.9. Some of the aberrant glycans showed response to therapy. Moreover, we identified a series of glycan traits with strong associations with the occurrence of laryngeal or gastrointestinal angioedema or disease severity score. Predictive models based on these traits could be used to predict disease severity (AUC > 0.9). These results were replicated in an independent cohort.ConclusionsWe reported the full plasma N‐glycomic signature of HAE for the first time, and identified potential biomarkers. These findings may play a critical role in predicting disease severity and guide the treatment of HAE in clinical practice. Further protein‐specific and prospective studies are needed to validate our findings.
A hybrid approach based on double roulette wheel selection and quadratic programming for cardinality constrained portfolio optimization
Authors: Hu Bo , Xiao Hui , Yang Nan , Jin Hao , Wang Lei 
Published: December 2021

SummaryThe portfolio optimization problem with cardinality constraint is usually solved by exact algorithms, heuristic algorithms, or combinations of them. We decompose the cardinality constraint mean‐variance model, and determine the assets and proportions by double roulette wheel selection (DRWS) and quadratic programming (QP), respectively. Then the accuracy of the solution is improved by a local search after we obtain the preliminary solution by combining DRWS and QP. Experimental results show that the proposed algorithm achieves better accuracy and more efficiency than the algorithms in the literature. Therefore, we can see that the algorithm designed according to the characteristics of specific problems can improve the computational efficiency, but the algorithm needs to be adjusted for different problems.
Prey life‐history influences the evolution of egg mass and indirectly reproductive investment in a group of free‐living insect predators
Authors: Hemptinne Jean‐Louis , Lecompte Emilie , Sentis Arnaud , Dixon Anthony F. G. , Magro Alexandra 
Published: December 2021

Abstract

The balance between risk and benefit of exploiting resources drives life‐history evolution in organisms. Predators are naturally recognized as major drivers of the life‐history evolution of their prey. Although prey may also influence the life‐history evolution of their predators in the context of an evolutionary arms race, there is far more evidence of the role of predators than of prey.

The goal of this study was to investigate the role of prey in life‐history evolution of predators using ladybird beetle predators of aphids and coccids. These particular ladybirds and their prey were chosen because literature shows that the pace of life of aphids is faster than that of coccids and this difference is reflected in the life histories of the ladybirds that specialize on feeding on aphids or coccids.

Thirty‐four species of ladybird predators of aphids and eight of coccids belonging to five different tribes were collected and reared in the laboratory. The females were weighed as well as their eggs, and their reproductive investment estimated as the number of ovarioles. Phylogenetic relatedness was controlled for in the statistical analyses.

Controlling for female mass revealed that ladybird predators of aphids lay bigger eggs than ladybird predators of coccids. This difference is not influenced by phylogenetic relatedness but only by the type of prey eaten. We suggest that ladybird predators of coccids lay smaller eggs because neonate larvae do not have to search, catch, and subdue prey. Both types of ladybirds have a similar reproductive investment relative to their body mass when phylogeny is controlled for.

Recognizing the influence of prey on the life‐history evolution of predators is important for understanding food web dynamics. From an applied perspective, this fine evolutionary tuning of prey–predator relationships should be used to guide and increase the efficiency of biological control programs.
Glutamine promotes the generation of B10+cells via the mTOR/GSK3 pathway
Authors: Mielle Julie , Morel Jacques , Elhmioui Jamila , Combe Bernard , Macia Laurence , Dardalhon Valérie , Taylor Naomi , Audo Rachel , Daien Claire 
Published: December 2021

AbstractAlterations in cell metabolism can shift the differentiation of immune cells toward a regulatory or inflammatory phenotype, thus, opening up new therapeutic opportunities for immune‐related diseases. Indeed, growing knowledge on T‐ cell metabolism has revealed differences in the metabolic programs of suppressive Tregs as compared to inflammatory Th1 and Th17 cells. In addition to Tregs, IL‐10‐producing regulatory B cells are crucial for maintaining tolerance, inhibiting inflammation, and autoimmunity. Yet, the metabolic networks regulating diverse B‐lymphocyte responses are not well known. Here, we show that glutaminase blockade decreased downstream mTOR activation and attenuated IL‐10 secretion. Direct suppression of mTOR activity by rapamycin selectively impaired IL‐10 production by B cells whereas secretion was restored upon Glycogen synthase kinase 3 (GSK3) inhibition. Mechanistically, we found mTORC1 activation leads to GSK3 inhibition, identifying a key signalling pathway regulating IL‐10 secretion by B lymphocytes. Thus, our results identify glutaminolysis and the mTOR/GSK3 signalling axis, as critical regulators of the generation of IL‐10 producing B cells with regulatory functions.
New Method Based on Polarity Reversal for Detecting Adulteration of Extra Virgin Olive Oil with Refined Olive Pomace Oil
Authors: Li Yonglin , Wen Shasha , Sun Yiwen , Zhang Na , Gao Yuan , Yu Xiuzhu 
Published: December 2021

AbstractExtra virgin olive oils (EVOO) are vulnerable to adulteration. Thus, a rapid and cost effective screening method is required to detect adulteration. This study develops a method for detecting EVOO adulterated with refined olive pomace oil (ROPO) based on polarity reversal method (PRM). A device is designed based on PRM to determine current of oil sample. Adulteration is detected according to the current difference between EVOOs and ROPOs caused by the content discrepancy of polar compounds. Polar phenolic components are characterized by high performance liquid chromatography‐mass spectrometry and Folin–Ciocalteu assay to confirm the principle of the proposed method. Calibration, validation, and blind sample validation is performed. Results showed that current of EVOOs is higher than that of ROPOs due to richer and higher content of polar phenolic compounds. Calibration of 5–90% adulteration withR2= 0.997 is established. TheR2of validation and blind sample validation are close to 1. The relative standard deviation of 5–90% adulterated samples and ROPO is 4.76%, indicating good accuracy and precision.Practical Applications: The proposed method can obtain adulterated ROPO content by simply referring the calibration curve of current within 10 min without pretreatment, which can be used in quick test for industry and retailers.
Wavelet and improved Hilbert–Huang transform method are used to study the spectrum distribution and energy of turbine pressure pulsation
Authors: Lan Chaofeng , Song Bowen , Li Shuijing , Zhang Lei 
Published: December 2021

AbstractIn order to reveal the relationship between steam turbine operating state and energy characteristics, the energy characteristics and frequency band distribution of steam turbine tail pipe pressure pulsation acquisition are studied. Wavelet analysis is used to remove the noise of steam turbine pressure pulsation signal, the noiseless signal is transformed by short‐time Fourier transform, and the energy histogram and energy proportion diagram of each frequency band are given. The traditional image continuation method is improved, the cubic Hermite interpolation method is used to replace the traditional cubic spline interpolation method, and then the traditional Hilbert–Huang transform (HHT) method is improved, which overcomes the endpoint effect problems, and reduces the overshoot and undershoot phenomenon in curve fitting to a certain extent. Using wavelet transform, empirical mode decomposition and improved HHT to study the distribution diagram, energy proportion diagram, and frequency band energy of pressure pulsation signal with frequency and time. The results show that with the increase of internal cavitation, the energy ratio in low‐frequency band decreases, the signal energy in high‐frequency band increases, the spectrum widens, and tends to the state of continuous spectrum.
Is social functioning in older age patients with bipolar disorder associated with affective and/or non‐affective cognition?
Authors: Paans Nadine PG , Korten Nicole , Orhan Melis , Ensing Anne , Schouws Sigfried NTM , Kupka Ralph , van Oppen Patricia , Dols Annemiek 
Published: December 2021

AbstractObjectivesPrevious research showed impairments in non‐affective cognition, affective cognition, and social functioning in adult patients with bipolar disorder (BD). Only 37% of adult BD patients recovers in social functioning, and both aspects of cognition are important constructs of influence. The role of affective cognition in older age bipolar disorder (OABD) patients is still unclear. Therefore, the aim of our study was to examine the separate and combined effects of affective cognition and non‐affective cognition on social functioning.MethodsThe current study included 60 euthymic patients (aged >60) of the Dutch Older Bipolar Study. Affective cognition was measured by Theory of Mind and Emotion Recognition. Non‐affective cognition was assessed through the measurements of attention, learning and memory, and executive functioning. Social functioning was examined through global social functioning, social participation, and meaningful contacts. The research questions were tested with linear and ordinal regression analyses.ResultsResults showed a positive association of all non‐affective cognitive domains with global social functioning. Associations between affective cognition and social functioning were non‐significant. Results did show an interaction between non‐affective and affective cognition.ConclusionsAssociations between non‐affective cognition and social functioning were confirmed, associations between affective cognition and social function were not found. For generalizability, studies with a greater sample size are needed. Conducting additional research about OABD patients and affective cognition is important. It may lead to more insight in impairment and guide tailored treatment that focusses more on all aspects of recovery and the needs of OABD patients.
The hippocampus supports high‐precision binding in visual working memory
Authors: Borders Alyssa A. , Ranganath Charan , Yonelinas Andrew P. 
Published: December 2021

AbstractIt is well established that the hippocampus is critical for long‐term episodic memory, but a growing body of research suggests that it also plays a critical role in supporting memory over very brief delays as measured in tests of working memory (WM). However, the circumstances under which the hippocampus is necessary for WM and the specific processes that it supports remain controversial. We propose that the hippocampus supports WM by binding together high‐precision properties of an event, and we test this claim by examining the precision of color‐location bindings in a visual WM task in which participants report the precise color of studied items using a continuous color wheel. Amnestic patients with hippocampal damage were significantly impaired at retrieving these colors after a 1‐s delay, and these impairments reflected a reduction in the precision of those memories rather than increases in total memory failures or binding errors. Moreover, a parallel fMRI study in healthy subjects revealed that neural activity in the head and body of the hippocampus was directly related to the precision of visual WM decisions. Together, these results indicate that the hippocampus is critical in complex high‐precision binding that supports memory over brief delays.
Analysis of rs1864182 and rs1864183 variants in ATG10 gene and antineutrophil cytoplasmic autoantibody‐associated vasculitis in Chinese Guangxi population
Authors: Huang Shanshan , Rao Jinlan , Wei Jingsi , Huang Qunshen , Zhu Yan , Li Wei , Xue Chao 
Published: December 2021

AbstractObjectivesTo investigate the association of autophagy‐associated gene 10 (ATG10) gene polymorphisms (rs1864182 and rs1864183) with antineutrophil cytoplasmic autoantibody (ANCA)‐associated vasculitis (AAV) in Chinese Guangxi population.MethodsThe single nucleotide polymorphisms (SNPs) of ATG10 rs1864182 and rs1864183 in 395 participants (195 AAVs and 200 healthy controls) were genotyped. Generalized multiple dimensionality reduction (GMDR) was used to analyze the SNP‐SNP interactions among two SNPs of ATG10 gene and other SNPs of autophagy gene previously studied by our research team.ResultsIn this study, we found that the two ATG10 SNPs were not associated with AAV risk in Chinese Guangxi population. However, there were statistically significant differences in the incidence of hemoptysis, hematuria, and proteinuria among the three genotypes of ATG10 rs1864182 and rs1864183 (p < 0.05). Moreover, permutation test of GMDR suggested that immunity‐related GTPase M(IRGM) rs4958847, autophagy‐associated gene 7 (ATG7) rs6442260, ATG7 rs2594966, ATG10 rs1864183, protein kinase B(AKT2) rs3730051, and AKT2 rs11552192 might interact with each other in the process of developing AAV (p < 0.05).ConclusionsOur results indicated that there existed no association between ATG10 SNPs and AAV, and SNP‐SNP interactions among IRGM rs4958847, ATG7 rs6442260, ATG7 rs2594966, ATG10 rs1864183, AKT2 rs3730051, and AKT2 rs11552192 may confer AAV risk in the Chinese Guangxi population.
The diagnostic role of PD‐1+ CXCR5+ follicular helper CD8+ T cell in renal allograft dysfunction
Authors: Fan Ji‐wen , Yan Lin , Wang Xue‐qiao , Li Ya‐mei , Bai Yang‐juan , Ou Xiao‐qi , Wan Zheng‐li , Li Yi 
Published: December 2021

AbstractBackgroundThe roles of PD‐1+CXCR5+ follicular helper CD8+ T cell were reported in different disease conditions, but their roles in transplantation are unclear. In this study, the association between PD‐1+CXCR5+ follicular helper CD8+ T cell and renal allograft dysfunction in kidney transplant recipients (KTRs) was investigated.Methods82 KTRs were enrolled in this study. 45 KTRs were included in the chronic allograft dysfunction (CAD) group, and 37 KTRs were included in the stable recipients group. Among the CAD group, 12 cases of antibody‐mediated rejection (ABMR) and 4 cases of T cell–mediated rejection (TCMR) were diagnosed by biopsy. The percentage of CXCR5+CD8+ T cells and the co‐expression of signal transducers and activators of transcription 4 (STAT4), STAT5, and PD‐1 in peripheral blood were determined by flow cytometry.ResultsThe expression of CXCR5 on CD3+CD8+ T cells and the percentage of STAT5+CXCR5+ cells in the CD3+CD8+ T‐cell population were significantly lower in the CAD group (p < 0.05), while the expression of PD‐1+CXCR5+CD8+ T cells was significantly higher (p < 0.05). Through logistic regression analysis, we concluded that the percentage of PD‐1+CXCR5+CD8+ T cells was an independent risk factor for renal dysfunction. Grouping by pathological type, PD‐1+CXCR5+CD8+ T cells showed relatively good diagnostic efficacy for ABMR by ROC analysis.ConclusionsOur results suggested that PD‐1+CXCR5+CD8+ T cells were a promising biomarker for distinguishing renal allograft dysfunction and different allograft pathological types. Also, our findings may provide new ways of identifying and treating allograft rejection.
MCAM is associated with metastasis and poor prognosis in osteosarcoma by modulating tumor cell migration
Authors: Du Xiaotian , Zhang Qin , Wang Siyuan , Chen Xiao , Wang Yue 
Published: December 2021

AbstractBackgroundAlthough there are standard treatment options for osteosarcoma (OS), the prognoses of patients with OS remain varied. Therefore, it is important to profile OS patients at a high risk of mortality to develop focused interventions. Although tumor biomarkers are closely associated with clinical outcomes, data on prognostic biomarkers for OS remain scarce.MethodsWe collected RNA expression profiles and clinical data of 90 OS patients from the GEO database (dataset GSE21257 and GSE39055) and 96 patients in the TARGET program. The data were analyzed using univariate Kaplan‐Meier survival analysis to screen candidate gene sets that might be associated with OS survival.ResultsOur analysis demonstrated that melanoma cell adhesion molecule (MCAM) was associated with overall survival of patients with OS in the three cohorts. The data showed that MCAM was upregulated in OS patients who had metastases within 5 years compared to those without metastases. GO analysis revealed that genes correlated with MCAM were mainly involved in cell migration and wound healing processes. In addition, wound healing assays and gene set enrichment analysis results from RNA sequencing data of small interfering (si)‐MCAM‐transfected OS cells demonstrated that MCAM modulated tumor cell migration.ConclusionsOur data demonstrate that MCAM may be a novel prognostic biomarker for OS. MCAM is associated with increased cell migration ability and risk of metastasis, thus leading to poor prognoses in OS patients.
Carboxyl terminus of HSP70‐interacting protein attenuates advanced glycation end products‐induced cardiac injuries by promoting NFκB proteasomal degradation
Authors: Lin Kuan‐Ho , Ali Ayaz , Kuo Chia‐Hua , Yang Pei‐Chen , Kumar Velmurugan B. , Padma Viswanadha V. , Lo Jeng‐Fan , Huang Chih‐Yang , Kuo Wei‐Wen 
Published: December 2021

AbstractAdvanced glycation end products (AGEs), which are highly reactive molecules resulting from persistent high‐glucose levels, can lead to the generation of oxidative stress and cardiac complications. The carboxyl terminus of HSP70 interacting protein (CHIP) has been demonstrated to have a protective role in several diseases, including cardiac complications; however, the role in preventing AGE‐induced cardiac damages remains poorly understood. Here, we found that elevated AGE levels impaired cardiac CHIP expression in streptozotocin‐induced diabetes and high‐fat diet‐administered animals, representing AGE exposure models. We used the TUNEL assay, hematoxylin and eosin, Masson′s trichrome staining, and western blotting to prove that cardiac injuries were induced in diabetic animals and AGE‐treated cardiac cells. Interestingly, our results collectively indicated that CHIP overexpression significantly rescued the AGE‐induced cardiac injuries and promoted cell survival. Moreover, CHIP knockdown‐mediated stabilization of nuclear factor κB (NFκB) was attenuated by overexpressing CHIP in the cells. Furthermore, co‐immunoprecipitation and immunoblot assay revealed that CHIP promotes the ubiquitination and proteasomal degradation of AGE‐induced NFκB. Importantly, fluorescence microscopy, a luciferase reporter assay, electrophoretic mobility shift assay, and subcellular fractionation further demonstrated that CHIP overexpression inhibits AGE‐induced NFκB nuclear translocation, reduced its binding ability with the promoter sequences of the receptor of AGE, consequently inhibiting the translocation of the receptor AGE to the cell membrane for its proper function. Overall, our current study findings suggest that CHIP can target NFκB for ubiquitin‐mediated proteasomal degradation, and thereby potentially rescue AGE‐induced cardiac damages.