bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bats in the megafire: assessing species’ site use in a postfire landscape in the Sierra Nevada
Authors: Mirts Haley E , McLaughlin John P , Weller Theodore J , White Angela M , Young Hillary S , Sollmann Rahel 
Published: October 2021

Abstract
Large high-severity fires are increasing in frequency in many parts of the world, including the coniferous forests of the Sierra Nevada mountains. These “megafires” alter vegetation and environmental conditions in forests, yet their impacts on native wildlife remain poorly understood. Bats play an important role in forest ecosystems, but their responses to megafires likewise are understudied. We investigated bat responses to the King Fire, a megafire that burned nearly 40,000 ha within the Eldorado National Forest in 2014, half of it at high severity. From June to September 2017, we used remote acoustic recorders to survey bats at 26 sites with varying fire severity (unburned, mixed, and high severity). We analyzed data with Royle–Nichols occupancy models to investigate how bat space use was influenced by megafires, and whether this response was driven by prey availability, fire severity, or fire-altered habitat conditions. We calculated prey species richness, biomass, and abundance, from moths sampled with blacklight surveys. Vegetation covariates included tree density, canopy cover, and shrub density, measured along vegetation transects. To capture general effects of fire, we also included fire severity and the percentage of dead trees as potential covariates on space use. Prey variables were highest in unburned forests, were the most common predictors of, and generally had positive effects on bat space use. Responses to tree density and canopy cover varied by species; the most common vegetation covariate, shrub density, had weak positive effects on bat space use. In spite of the varying prey and vegetation conditions across fire severity categories, most bats showed weak to no response in space use to fire severity and tree mortality. We attribute this to the highly mobile nature of bats, which reduces the impact of potentially negative local conditions.
Perception and Process: Towards a Behavioural Theory of Compliance
Authors: Peat Daniel 
Published: October 2021

ABSTRACT
Nowhere is the integration of behavioural insights into international legal theory more important than in relation to compliance. Such insights offer the potential to give us a more accurate understanding of how states behave, permitting both the development of more effective, empirically grounded normative propositions for legal and institutional change, as well as the creation of more convincing theories of compliance. Drawing on theoretical, empirical and experimental studies from political science and international relations, the article suggests that we need to understand compliance decision-making as a broader process that requires analysis of how and why decision-makers perceive new information the way that they do, and how the process by which they make decisions, such as their style of reasoning, might affect decision outcomes. To develop this point, the article uses data from international financial institutions and a novel sentiment analysis of Argentinian parliamentary debates to test empirically hypotheses generated by realist, liberal, and constructivist theories of compliance, the results of which demonstrate the benefit of adopting a behavioural approach to compliance.
Spindle Cell Sarcoma (SCS); a case of primary leiomyosarcoma (LMS) of the sigmoid colon presented as intestinal obstruction
Authors: Al Laham Omar , Albrijawy Reham , Atia Fareed , Shaheen Jack , AlTabbakh Hani 
Published: October 2021

Abstract
Leiomyosarcoma (LMS) is a common form of soft tissue sarcoma. Primary colonic LMS is an extremely rare entity, comprising 1–2% of gastrointestinal malignancies. Primary mesenchymal sarcomas of the gastrointestinal system are rare and constitute just 0.1–3% of all gastrointestinal tumours. LMS is the most common variant of such tumours and represents just 0.12% of colorectal malignancies.
We present a case of a 65-year-old female, who presented to the emergency department with 3 days history of obstipation and generalized abdominal pain. Radiology (X-ray and ultrasound) indicated a large pelvic mass compressing the sigmoid colon and its surrounding structures.
Histopathological analysis indicated a primary LMS of the sigmoid colon. Diagnosis is established mostly postoperatively after histopathological evaluation. Prognosis and treatment modalities for this aggressive malignancy remain insufficient. LMS is relatively impervious to chemotherapy/radiotherapy. Our patient was treated by surgical excision of the tumour and referred postoperatively for adjuvant chemotherapy.
Responses of a Pre-hospital Emergency Medical Service During Military Conflict Versus COVID-19: A Retrospective Comparative Cohort Study
Authors: Jaffe Eli , Sonkin Roman , Alpert Evan Avraham , Zerath Erik 
Published: October 2021

ABSTRACT

Background
Decreases in routine healthcare practices have been shown to occur during disasters. However, research regarding the impacts of natural disasters, pandemics, or military conflicts on emergency medical services (EMS) is scarce.

Objectives
This study assessed the impact of a military conflict versus the coronavirus disease 2019 (COVID-19) pandemic on a national EMS organization in terms of responses to overall daily emergencies, medical illnesses, motor vehicle collisions, and other injuries.

Methods
This retrospective comparative cohort study assessed daily routine emergency ambulance calls to Magen David Adom (MDA), Israel’s national EMS organization. This included overall emergency calls as well as those related to medical illnesses, motor vehicle collisions (MVCs), and other injuries. All data were obtained from the MDA command and control database. During the military conflict Operation Protective Edge (2014), the civilian population was subjected to intensive rocket attacks for 24 days, followed by 26 days of a progressive withdrawal of operations and then to a post-conflict period. During the first wave of the COVID-19 pandemic (March-April 2020), the population was subjected to 32 days of total lockdown, followed by 27 days of progressive relief of confinement, and then to a post-lockdown period.

Results
The total number of emergency calls in this study was 330,430. During the conflict, the mean number of daily calls decreased, followed by an increase during Relief and Post-Conflict with higher values in Post-Conflict than in Pre-Conflict. During the COVID-19 pandemic, there was a decrease in the mean daily number of calls during Lockdown. It remained low during Relief and increased during Post-Lockdown. However, it remained lower in Post-Lockdown than during Pre-Lockdown. Calls related to medical illnesses decreased during the conflict and during the lockdown. The post-conflict period was characterized by a similar baseline call magnitude but not during the post-lockdown period. Decreases in calls for MVC and other injuries were significant during the lockdown but not during the military conflict. Post-lockdown was accompanied by return to baseline call volumes for MVC, whereas calls for other injuries increased above baseline both after the lockdown and military conflict.

Conclusion
This study shows decreasing trends in routine daily calls for EMS during both Operation Protective Edge and COVID-19. However, different patterns of needs for EMS were evidenced for medical illnesses, MVC, or calls concerning other injuries. These results are instrumental for managing the operational demands of EMS during military conflicts and pandemics.
HPV-Related Cancers: A Growing Threat to U.S. Military Health and Readiness
Authors: Seay Julia , Matsuno Rayna , Buechel Jennifer , Tannenbaum Karen , Wells Natalie 
Published: October 2021

ABSTRACT
The incidence of human papillomavirus (HPV) related cancers is growing in the United States. Active duty service members (ADSM) have higher rates of HPV infection than civilians and are therefore at greater risk of developing HPV-related cancers. The purpose of this commentary is to examine the burden of HPV-related cancers in ADSM. The current HPV vaccination and cervical cancer screening uptake rates of U.S. ADSM are presented, including a literature review of military-focused studies on HPV vaccination and cervical cancer screenings. We provide directions for future research, interventions, and policy recommendations to improve HPV-related cancer prevention among ADSM.
Mechanistic studies of the cofactor assembly in class Ib ribonucleotide reductases and protein affinity for MnII and FeII
Authors: Jayachandran Megha , Yoon Jennifer , Wu Jacky , Cipurko Denis , Quon Joyce , Makhlynets Olga 
Published: October 2021

Abstract
Ribonucleotide reductase (RNR) is an essential enzyme found in all organisms. The function of RNR is to catalyze the conversion of nucleotides to deoxynucleotides. RNRs rely on metallocofactors to oxidize a conserved cysteine in the active site of the enzyme into a thiyl radical, which then initiates nucleotide reduction. The proteins required for MnIII2–Y• cluster formation in class Ib RNRs are NrdF (β-subunit) and NrdI (flavodoxin). An oxidant is channeled from the FMN cofactor in NrdI to the dimanganese center in NrdF, where it oxidizes the dimanganese center and a tyrosyl radical (Y•) is formed. Both Streptococcus sanguinis and Escherichia coli MnII2–NrdF structures have a constriction in the channel immediately above the metal site. In E. coli, the constriction is formed by the side chain of S159, whereas in the S. sanguinis system it involves T158. This serine-to-threonine substitution was investigated using S. sanguinis and Streptococcus pneumoniae class Ib RNRs but it is also present in other pathogenic streptococci. Using stopped-flow kinetics, we investigate the role of this substitution in the mechanism of MnIII2–Y• cluster formation. In addition to different kinetics observed in the studied streptococci, we found that affinity constants of NrdF for MnII and FeII are about 1 µM and the previously reported preference for MnII could not be explained by affinity only.
Establishing Auditing Intermediaries to Verify Platform Data
Authors: Wagner Ben , Kuklis Lubos 
Published: October 2021

Abstract
This chapter provides an overview of the main problems associated with basing public regulatory decisions on unverified data, before sketching out some ideas of what a solution might look like. In order to do this, the chapter develops the concept of auditing intermediaries. After discussing which problems the concept of auditing intermediaries is designed to solve, it then discusses some of the main challenges associated with access to data, potential misuse of intermediaries, and the general lack of standards for the provision of data by large online platforms. In conclusion, the chapter suggests that there is an urgent need for an auditing mechanism to ensure the accuracy of transparency data provided by large online platform providers about the content on their services. Transparency data that have been audited would be considered verified data in this context. Without such a transparency verification mechanism, existing public debate is based merely on a whim, and digital dominance is likely to only become more pronounced.
Characterising the Distinct Crustal Protoliths of Roberts Victor Type I and II Eclogites
Authors: Hardman Matthew F , Stachel Thomas , Pearson D Graham , Cano Erick J , Stern Richard A , Sharp Zachary D 
Published: October 2021

Abstract
The origin of the eclogites that reside in cratonic mantle roots has long been debated. In the classic Roberts Victor kimberlite locality in South Africa, the strongly contrasting textural and geochemical features of two types of eclogites have led to different genetic models. We studied a new suite of 63 eclogite xenoliths from the former Roberts Victor Mine. In addition to major- and trace-element compositions for all new samples, we determined 18O/16O for garnet from 34eclogites. Based on geochemical and textural characteristics we identify a large suite of Type I eclogites (n = 53) consistent with previous interpretations that these rocks originate from metamorphosed basaltic-picritic lavas or gabbroic cumulates from oceanic crust, crystallised from melts of depleted mid-ocean ridge basalt (MORB) mantle. We identify a smaller set of Type II eclogites (n = 10) based on geochemical and textural similarity to eclogites in published literature. We infer their range to very low δ18O values combined with their varied, often very low zirconium-hafnium (Zr-Hf) ratios and light rare earth element-depleted nature to indicate a protolith origin via low-pressure clinopyroxene-bearing oceanic cumulates formed from melts that were more depleted in incompatible elements than N-MORB. These compositions are indicative of derivation from a residual mantle source that experienced preferential extraction of incompatible elements and fractionation of Zr/Hf during previous melting.
Creating an Applied, Multi-disciplinary Research Field: The World Health Organization and Health Systems Research 1960–2000
Authors: Weisz George 
Published: October 2021

Summary
From the 1960s, the World Health Organization (WHO) sought to reconcile ambitious international goals with scarce resources and the socio-economic realities of low- and middle-income countries by developing a field called Health Systems Research (HSR). This field remained small, marginal and largely confined to WHO during the second half of the twentieth century. The WHO worked to promote HSR, apply it to concrete problems and define its scope and methodologies while linking it to policymaking. Results were seriously limited by lack of interest from policymakers, confusion about its scope and methods, and competition from numerous disciplines working on overlapping subjects, notably economic analysis. This latter rivalry originated with debates about Primary Health Care versus Selective Primary Healthcare in the late 1970s and was overcome, rhetorically, in the late 1980s. Tensions however remained, and by the end of the twentieth century, economic analysis had temporarily triumphed at the WHO.
Treatment of small cell lung cancer: recent advances
Authors: Chu Xiangling , Han Chaonan , Su Chunxia 
Published: October 2021

Purpose of review
In this article, we aimed to summarize the recent progress being made in treatment of small cell lung cancer (SCLC).

Recent findings
SCLC is characterized by strong invasiveness, easy recurrence and early metastasis. In recent years, the emergence of immune checkpoint inhibitors (ICIs) therapy has broken the deadlock in the treatment field of SCLC. Combination strategies, such as the addition of ICIs to chemotherapy and radiotherapy, are actively underway. Some of these strategies have yielded significant survival benefits and tolerable adverse events, whereas several of them have failed with no significant improvement. In addition, the new classification of SCLC based on genomic analysis has deepened the understanding of SCLC and suggested new therapeutic directions. Similarly, the discovery of some new therapeutic targets, such as DDL3, CDK7 and PARP, also brings new hope for improving the survival of patients with SCLC.

Summary
In this article, we will review the recent advances of therapeutic regimen for patients with SCLC. Following the revolutionary success of adding ICIs to chemotherapy, more varieties of combination strategies have been explored in recent trials. In addition, therapeutic drug research and efficacy evaluation against for new targets are under investigation. Altogether, progress on genomic analysis, investigation of biological pathways and treatment regimen combination are providing renewed hope for patients with SCLC.
Regularity and Timing of Sleep Patterns and Behavioral Health Among Adolescents
Authors: Lunsford-Avery Jessica R. , Wang Ke (Will) , Kollins Scott H. , Chung Richard J. , Keller Casey , Engelhard Matthew M. 
Published: October 2021

ABSTRACT:

Objective:
Sleep is vital to supporting adolescent behavioral health and functioning; however, sleep disturbances remain under-recognized and undertreated in many health care settings. One barrier is the complexity of sleep, which makes it difficult for providers to determine which aspects—beyond sleep duration—may be most important to assess and treat to support adolescent health. This study examined associations between 2 sleep indices (regularity and timing) and adolescent behavioral health and functioning over and above the impact of shortened/fragmented sleep.

Method:
Eighty-nine adolescents recruited from the community (mean age = 14.04, 45% female participants) completed 7 days/nights of actigraphy and, along with a parent/guardian, reported on behavioral health (internalizing and externalizing symptoms) and psychosocial functioning. Stepwise linear regressions examined associations between sleep timing and regularity and behavioral/functional outcomes after accounting for shortened/fragmented sleep.

Results:
Delayed sleep timing was associated with greater self-reported internalizing (F[6,82] = 11.57, p = 0.001) and externalizing (F[6,82] = 11.12, p = 0.001) symptoms after accounting for shortened/fragmented sleep. Irregular sleep was associated with greater self-reported and parent-reported externalizing symptoms (self: F[7,81] = 6.55, p = 0.01; parent: F[7,80] = 6.20, p = 0.01) and lower psychosocial functioning (self: F[7,81] = 6.03, p = 0.02; parent: F[7,78] = 3.99, p < 0.05) after accounting for both shortened/fragmented sleep and delayed sleep timing.

Conclusion:
Sleep regularity and timing may be critical for understanding the risk of poor behavioral health and functional deficits among adolescents and as prevention and intervention targets. Future work should focus on developing and evaluating convenient, low-cost, and effective methods for addressing delayed and/or irregular adolescent sleep patterns in real-world health care settings.
Infant Mental Health Home Visiting Mitigates Impact of Maternal Adverse Childhood Experiences on Toddler Language Competence: A Randomized Controlled Trial
Authors: Riggs Jessica L. , Rosenblum Katherine L. , Muzik Maria , Jester Jennifer , Freeman Sarah , Huth-Bocks Alissa , Waddell Rachel , Alfafara Emily , Miller Alison , Lawler Jamie , Erickson Nora , Weatherston Debbie , Shah Prachi , Brophy-Herb Holly ,   the Michigan Collaborative for Infant Mental Health Research
Published: October 2021

ABSTRACT:

Objective:
The goal of this study was to test the impact of maternal adverse childhood experiences (ACEs) on subsequent child language competence; higher parental ACEs were expected to predict risk of toddler language delay. Participation in Infant Mental Health Home Visiting (IMH-HV) treatment, which aims to enhance responsive caregiving and improve child social-emotional development, was expected to mitigate this association.

Methods:
A randomized controlled trial (RCT) design was used. ACEs data were collected at baseline. Child language screening (using the Preschool Language Scales Screening Test) was conducted 12 months later by masters-level evaluators who were blind to treatment condition. Visits occurred in participants' homes. Participants were community-recruited and were randomized to treatment (psychotherapeutic IMH-HV) or control (treatment as usual). Data come from 62 families who participated in all waves of an RCT testing the efficacy of IMH-HV; mothers were eligible based on child age (<24 mo at enrollment) and endorsement of ≥2 sociodemographic eligibility criteria (economic disadvantage, depression, perceived parenting challenges, and/or high ACEs).

Results:
The age of mothers enrolled in this ranged from 19 to 44 years (M = 31.91; SD = 5.68); child age at baseline ranged from prenatal to 26 months (M = 12.06; SD = 6.62). The maternal ACE score predicted child language competence (t (5,55) = −3.27, p = 0.002). This effect was moderated by treatment (t (6,54) = 1.73, p = 0.04), indicating no association between maternal ACEs and child language for those randomized to IMH-HV.

Conclusion:
The results highlight that the effects of parent ACEs on early childhood outcomes may be buffered by participation in psychotherapeutic home visiting (trial registration: NCT03175796).
Youth, Caregiver, and Provider Perception of the Transition from Pediatric to Adult Care for Youth with Chronic Diseases
Authors: Tsang Vivian W. L. , Fletcher Sarah , Jassemi Sara , Smith Sharon 
Published: October 2021

ABSTRACT:

Objective:
Youth with chronic diseases are required to transition from pediatric to adult care across the world at variable ages in their adolescent years. The aim of this study is to examine perspectives of young patients, caregivers, and physicians in the transition process.

Methods:
This 3-phase mixed methods research study gathered data using an iterative approach with the collaboration of youth coresearchers. Physician opinions were gathered through a survey. Further data were collected through 15 semistructured, standardized interviews of adolescent medicine physicians. Perspectives of adolescents and young adult (AYA) patients and their caregivers were gathered independently using a 20-item survey. Quantitative data were analyzed with descriptive statistics and sorted by theme.

Results:
In phase 1, respondents rated current transition processes as an average 5.19/10 on a 10-point Likert scale (1 = poor and 10 = excellent) with no participants rating 9 or 10 of 10. The top barrier identified was a lack of communication between pediatric and adult doctors (71.0%). The top ranked strategy for improvement was to provide formal transition guidelines (69.8%). In phase 2, specific concerns include lack of insurance coverage, lack of physicians available to take on youth transitioning to adult care who are also knowledgeable regarding pediatric conditions, and lack of funding or staff support for transition clinics. In phase 3, most of the youth surveyed (52%) reported that their physicians have not involved them in conversations about transitioning. AYA patients prefer the point of transfer to occur with other life transitions such as graduation, and caregivers prefer transfer to happen during times of stability where their children can dedicate adequate time to their health.

Conclusion:
Fulfilling youth desire for increased patient autonomy and ownership can help overcome their poor perception of the transition process. Increased physician training in adolescent health and improvements in post-transition community plans may be beneficial to prevent loss to follow-up among young patients across medical disciplines. Successful transition into adult care requires a unique process for each youth and requires adequate preparation from the pediatric front, empowerment of young patients and their families, and continuity of care by adult providers.