bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-instrument STIX microflare study
Authors: Saqri Jonas , Veronig Astrid M. , Warmuth Alexander , Dickson Ewan C. M. , Battaglia Andrea Francesco , Podladchikova Tatiana , Xiao Hualin , Battaglia Marina , Hurford Gordon J. , Krucker Säm 
Published: December 2021

Context. During its commissioning phase in 2020, the Spectrometer/Telescope for Imaging X-rays (STIX) on board the Solar Orbiter spacecraft observed 69 microflares. The two most significant events from this set (of GOES class B2 and B6) were observed on-disk from the spacecraft as well as from Earth and analysed in terms of the spatial, temporal, and spectral characteristics.
Aims. We complement the observations from the STIX instrument with EUV imagery from SDO/AIA and GOES soft X-ray data by adding imaging and plasma diagnostics over different temperature ranges for a detailed microflare case study that is focussed on energy release and transport.
Methods. We used data from the GOES for SXR plasma diagnostics and SDO/AIA for carrying out high-cadence EUV imaging and reconstruction of differential emission measure (DEM) maps of the thermal flare plasma. The reconstructed DEM profiles were used to study the temporal evolution of thermal flare plasma in the kernels and loops independently. We derived the time evolution of the flare plasma parameters (EM, T) and thermal energy from STIX, GOES, and AIA observations. In particular, we studied the STIX spectra to determine the nonthermal emission from accelerated electrons.
Results. A spectral fitting of the STIX data shows clear nonthermal emission for both microflares studied here. For both events, the plasma temperature and EM derived from STIX and GOES as well as the reconstructed DEM maps differ in absolute values and timing, with AIA (which is sensitive to lower plasma temperatures) lagging behind. The deduced plasma parameters from either method roughly agree with the values in the literature for microflares as do the nonthermal fit parameters from STIX. This finding is corroborated by the Neupert effect exhibited between the time derivative of the GOES SXR emission and the STIX HXR profiles. For the B6 event, for which such an analysis was possible, the non-thermal energy deduced from STIX roughly coincides with the lower estimates of the thermal energy requirement deduced from the SXR and EUV emissions.
Conclusions. The observed Neupert effects and impulsive and gradual phases indicate that both events covered in this study are consistent with the standard chromospheric evaporation flare scenario. For the B6 event on 7 June 2020, this interpretation is further supported by the temporal evolution seen in the DEM profiles of the flare ribbons and loops. For this event, we also find that accelerated electrons can roughly account for the required thermal energy. The 6 June 2020 event demonstrates that STIX can detect nonthermal emission for GOES class B2 events that is nonetheless smaller than the background rate level. We demonstrate for the first time how detailed multi-instrument studies of solar flares can be performed with STIX.
Open access journals are as likely to be referenced by the Orthopaedic literature, despite having a lower impact factor than subscription-based journals
Authors: Cooke Robert , Jain Neil 
Published: December 2021

Background: The internet has changed the way we access and publish Orthopaedic literature. Traditional subscription journals have been challenged by the open access method of publication which permits the author to make their article available to all readers for free, often at a cost to the author. This has also been adopted in part by traditional subscription journals forming hybrid journals. One of the criticisms of open access publications is that it provides the author with a “pay to publish” opportunity. We aimed to determine if access to the journals impacts their influence. Methods: We selected the top 40 Trauma and Orthopaedic Journals as ranked by the SCImago Rank. Each journal was reviewed and assessed for the journal quality, defined by reviewing the journal impact factor and SCImago rank; influence, defined by reviewing the top 10 articles provided by the journal for the number of citations; and cost of open access publication. Results: Of the top 40 journals, 10 were subscription, 10 were open access, and 20 were hybrid journals. Subscription journals had the highest mean impact factor, and SCImago rank with a significant difference in the impact factor (p = 0.001) and SCImago rank (p = 0.021) observed between subscription and open access journals. No significant difference was seen between citation numbers of articles published in subscription and open access journals (p = 0.168). There was a positive correlation between the cost of publishing in an open access journal and the impact factor (r = 0.404) but a negative correlation between cost and the number of citations (r = 0.319). Conclusion: Open access journals have significantly lower quality measures in comparison to subscription journals. Despite this, we found no difference between the number of citations, suggestive of there being no difference in the influence of these journals in spite of the observed difference in quality.
Management of Vascular Thrombosis in Patients with Thrombocytopenia
Authors: Voigtlaender Minna , Langer Florian 
Published: December 2021

AbstractPlatelets play critical roles in hemostasis and thrombosis. While low platelet counts increase the risk of bleeding, antithrombotic drugs, including anticoagulants and antiplatelet agents, are used to treat thromboembolic events. Thus, the management of thrombosis in patients with low platelet counts is challenging with hardly any evidence available to guide treatment. Recognition of the underlying cause of thrombocytopenia is essential for assessing the bleeding risk and tailoring therapeutic options. A typical clinical scenario is the occurrence of venous thromboembolism (VTE) in cancer patients experiencing transient thrombocytopenia during myelosuppressive chemotherapy. In such patients, the severity of thrombocytopenia, thrombus burden, clinical symptoms, and the timing of VTE relative to thrombocytopenia must be considered. In clinical practice, distinct hematological disorders characterized by low platelet counts and a thrombogenic state require specific diagnostics and treatment. These include the antiphospholipid syndrome, heparin-induced thrombocytopenia (HIT) and (spontaneous) HIT syndromes, disseminated intravascular coagulation, and paroxysmal nocturnal hemoglobinuria.
Vom „wesensfremden Konsum“ – Zum Umgang mit
der Alkoholproblematik in einem DDR-Großbetrieb
Authors: Haack Kathleen , Schrödter Anton , Grabe Hans Jörgen , Kumbier Ekkehardt 
Published: December 2021

ZusammenfassungDer Beitrag widmet sich dem Umgang mit der Alkoholproblematik in der DDR und
spezifisch in Rostock anhand des 1983 entstandenen Dokumentarfilms
„Abhängig“. Dabei geht es nicht um eine dezidierte
Filmanalyse. Vielmehr fungiert er als Anlass, sich aus mikrohistorischer
Perspektive mit den verschiedenen Dimensionen des Umgangs mit Alkoholkranken in
einem DDR-Großbetrieb auseinanderzusetzen. Aus historischer Sicht ist
der Dokumentarfilm gleich in mehrfacher Hinsicht interessant und eignet sich
hervorragend als Quelle und Analyseinstrument der DDR-Psychiatriegeschichte. Es
ist das Ineinandergreifen ideen- und sozialgeschichtlicher Perspektiven, die die
Spannung zwischen gesellschaftlicher Ächtung einerseits und Anerkennung
des Alkoholismus als Krankheit andererseits über das Medium Film
erfahrbar macht, zudem Versuche der Etablierung von Therapien in
multiprofessionellen Teams und damit Wege aus der Sucht aufzeigt.
Ergänzend wird auf erstmals eingesehenes umfangreiches Archivmaterial
sowie Zeitzeugeninterviews zurückgegriffen. Nicht zuletzt
ermöglicht der Einblick in den Sozialraum „volkseigener“
Großbetrieb (Neptunwerft mit Betriebspoliklinik) einen differenzierten
Zugang in die realsozialistische Gesellschaft und deren spezifischen Umgang mit
– im weitesten Sinn – abweichenden und in der jeweiligen
Interpretation randständig-asozialem oder krankhaftem
übermäßigen Alkoholkonsum. Neben dem Aufzeigen
verschiedener Sichtweisen auf die Alkoholproblematik in der DDR, in deren
Verlauf eine Ausweitung des medizinischen Definitionsbereichs erfolgte, zielt
der Beitrag darauf, Anstöße für vergleichende
Forschungen zu geben, notwendige Perspektivwechsel aufzuzeigen und langfristig
allgemeingültige Aussagen über die Rolle der Psychiatrie im
Kontext des Gesundheitswesens der DDR zu treffen.
Outcomes in Pediatric Endoscopic Skull Base Surgery: A Systematic Review
Authors: Lopez Erin M. , Farzal Zainab , Dean Kelly M. , Miller Craig , Morse Justin C. , Ebert Charles S. , Kimple Adam J. , Thorp Brian D. , Zanation Adam M. 
Published: December 2021

Abstract
Objectives The frequency of endoscopic skull base surgery in pediatric patients is increasing. This study aims to systematically review the literature for endoscopic skull base surgery outcomes in children/adolescents aged 0 to 18 years.
Design A systematic review of the literature was performed in PubMed and SCOPUS databases querying studies from 2000 to 2020 using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Final inclusion criteria included: case series with more than 10 patients with pediatric patients aged ≤18 years, endoscopic or endoscopic-assisted skull base surgery, and outcomes reported.
Setting This study was conducted at a tertiary care medical center.
Participants Children/adolescents aged 0 to 18 years who underwent endoscopic skull base surgery were participated in this study.
Main Outcome Measures Patient demographics, pathology, reconstructive technique, intraoperative findings, intraoperative, and postoperative surgical complications were measured through this study.
Results Systematic literature search yielded 287 publications. Of these, 12 studies discussing a total of 399 patients aged 0 to 18 years met inclusion criteria for final analysis. Seven of the 12 studies discussed a single pathology. The most common pathology was a skull base defect causing cerebrospinal fluid (CSF) leak. The majority of skull base repairs were made with free tissue grafts. The most common postoperative complication was CSF leak (n = 40). Twelve cases of meningitis occurred postoperatively with two of these episodes resulting in death.
Conclusion Endoscopic skull base surgery has been performed recently in the pediatric population in a variety of disease states. Inconsistent individual-level data and reporting standards are present in existing studies posing challenges for comparative analysis. Standardized reporting will aid future reviews and meta-analysis for rare skull base pathology.
Gender Dysphoria in the Pediatric Population: Initial Experience of a Transdisciplinary Group
Authors: Moreno-Bencardino Camila , Zuluaga Laura , Perez Jaime , Cespedes Camila , Forero Catalina , Fernandez Nicolas 
Published: December 2021

Abstract
Introduction Although there is an increasing experience in the management of transgender individuals, this has not been thoroughly explored in children. The need to establish a comprehensive and transdisciplinary management is of critical importance. In order to solve this issue, we want to report the results of a cohort of individuals with gender dysphoria (GD) seen by our transdisciplinary group from a social and clinical and health access perspective.
Methods A 10-year retrospective case series of all patients that had been seen by our transdisciplinary team was reviewed. The main demographic characteristics were described, as well as impact variables in terms of diagnosis and treatment of these individuals. A social description of each individual was described. Frequency, distribution, and central tendency measures were evaluated for data presentation. IBM SPSS Statistics for Windows, version 24.0 (IBM Corp, Armonk, NY) software was used.
Results Four cases of GD were included. Three had male to female dysphoria and one female to male. The median reported age of GD awareness was 6 years old (between 4 and 8 years old), and the median time between GD awareness and the 1st medical evaluation was 7 years for all individuals. The median age at gender role expression was 12 years old (between 10 and 14 years old). All patients had already assumed their experienced gender role before the 1st evaluation by our group. The median age at the 1st evaluation by our group was 13 years old (between 10 and 16 years old); three of the patients were evaluated after initiation of puberty. In the present study, individuals with GD demonstrated having health care access barriers for their transition process. Referral times are high, and individuals with GD are cared after pubertal development, which is related to suboptimal outcomes. The spectrum of GD is broad, and management must be individualized according to expectations.
Conclusion Individuals with GD face multiple access barriers that limit their possibility of being seen by a transdisciplinary team. This reflects in longer waiting times that negatively impact medical management. Gender dysphoria is a wide spectrum, and individuals should be evaluated individually by a transdisciplinary team.
Treatment of Unique Bilateral Distal Fusiform Superior Cerebellar Artery Aneurysms with Mini-Flow Diverter Device Implantation: Case Report
Authors: Hofmann Björn B. , Rubbert Christian , Turowski Bernd , Hänggi Daniel , Muhammad Sajjad 
Published: December 2021

AbstractCurrently, surgical revascularization procedures using intracranial–intracranial (IC-IC) or extracranial–intracranial (EC-IC) bypass and distal clipping or trapping are the valid and rescue treatment modality for extremely rare unilateral distal fusiform superior cerebellar artery (SCA) aneurysms. Yet, in case of bilateral fusiform SCA aneurysms, surgical therapy reaches its limit. Mini-flow diverter devices (FDDs) have only recently become available for treating fusiform aneurysms of such small vessels. We report the unique case of bilateral distal fusiform SCA aneurysms in a 43-year-old man with subarachnoid hemorrhage (Fisher grade IV and World Federation of Neurosurgical Societies [WFNS] grade II) treated with endovascular implantation of bilateral mini-FDDs with excellent outcome and no radiographic signs of infarction. Yet, occlusion of one of the FDDs was found in the follow-up, which again shows the eminent danger of occlusion in case of an implantation of FDDs in such small-caliber vessels, which leaves the discussion about the optimal therapy method open.
Vertebroplasty, Kyphoplasty, and Implant-Based Mechanical Vertebral Augmentation
Authors: Key Brandon M. , Symanski John , Scheidt Matthew J. , Tutton Sean M. 
Published: December 2021

AbstractVertebral compression fractures are a global public health issue with a quantifiable negative impact on patient morbidity and mortality. The contemporary approach to the treatment of osteoporotic fragility fractures has moved beyond first-line nonsurgical management. An improved understanding of biomechanical forces, consequential morbidity and mortality, and the drive to reduce opioid use has resulted in multidisciplinary treatment algorithms and significant advances in augmentation techniques. This review will inform musculoskeletal radiologists, interventionalists, and minimally invasive spine surgeons on the proper work-up of patients, imaging features differentiating benign and malignant pathologic fractures, high-risk fracture morphologies, and new mechanical augmentation device options, and it describes the appropriate selection of devices, complications, outcomes, and future trends.
Tumor fibroblástico inguinal superficial positivo para CD34. Reporte de un caso y revisión de la literatura
Authors: Linares R Francisco , Messa B Oscar , Cuello G Sebastián , Martín V Helbert 
Published: December 2021

ResumenEl tumor fibroblástico superficial de tejidos blandos positivo para antígeno CD34 (CD34) es un tumor raro, de baja frecuencia, que se caracteriza histológicamente por un marcado pleomorfismo, baja actividad mitótica, e inmunoreactividad difusa para CD34. Puede tener un comportamiento similar al de un tumor mesenquimal de malignidad intermedia. Existen sólo 52 casos publicados en la literatura. Se presenta el caso de una paciente de 31 años con una masa en tejidos blandos en región inguinal izquierda, de crecimiento progresivo, de varios meses de evolución dolorosa. La masa fue biopsiada y, con la sospecha de un tumor fibroblástico superficial positivo para CD34, fue posteriormente tratada con una resección ampliada de la lesión y con cobertura del defecto en la piel con un colgajo local de avance de V-Y, con una evolución satisfactoria en su seguimiento postquirúrgico. El reporte de patología confirmó la sospecha diagnóstica de un tumor con reactividad fuerte para CD34, con proteína P53 en 60% a 70%, antígeno Ki67 menor al 15%, sin pérdida de proteína nuclear INI-1, y negatividad para CD31, CD163, AE1AE3, CAM5.2, EMA, CD30, receptores de progestágenos, proteína S100, y desmina, con bordes negativos.
Nivel de evidencia IV.
Radiofrequency Ablation of Spine Metastases: A Clinical and Technical Approach
Authors: Yevich Steven , Chen Stephen , Metwalli Zeyad , Kuban Joshua , Lee Stephen , Habibollahi Peiman , McCarthy Colin J. , Irwin David , Huang Steven , Sheth Rahul A. 
Published: December 2021

AbstractPercutaneous radiofrequency ablation (RFA) is an integral component of the multidisciplinary treatment algorithm for both local tumor control and palliation of painful spine metastases. This minimally invasive therapy complements additional treatment strategies, such as pain medications, systemic chemotherapy, surgical resection, and radiotherapy. The location and size of the metastatic lesion dictate preprocedure planning and the technical approach. For example, ablation of lesions along the spinal canal, within the posterior vertebral elements, or with paraspinal soft tissue extension are associated with a higher risk of injury to adjacent spinal nerves. Additional interventions may be indicated in conjunction with RFA. For example, ablation of vertebral body lesions can precipitate new, or exacerbate existing, pathologic vertebral compression fractures that can be prevented with vertebral augmentation. This article reviews the indications, clinical work-up, and technical approach for RFA of spine metastases.
Interpretación medicolegal para el abordaje de individuos con desórdenes del desarrollo sexual en Colombia
Authors: Fernandez Nicolas , Zuluaga Laura , Perez Maria Fernanda , Perez Jaime , Cespedes Camila , Forero Catalina , Orjuela Camilo , Suarez Fernando 
Published: December 2021

Resumen
Objetivo Los desórdenes del desarrollo sexual (DDSs) son un grupo de condiciones médicas cuyo manejo implica un enfoque transdisciplinario. En la legislación colombiana, no existe una regulación específica en materia de intervenciones médicas en individuos con DDSs. La Corte Constitucional Colombiana se ha encargado de proferir sentencias, en las cuales se han establecido unos lineamientos y parámetros para el manejo jurídico de los casos de ambigüedad genital.Teniendo en cuenta lo anterior, nos proponemos en este artículo exponer y analizar, desde la visión de un grupo transdisciplinario, las sentencias más relevantes que han sido proferidas por la Corte Constitucional Colombiana.
Métodos Se realizó una revisión narrativa en las bases de datos de la Corte Constitucional y de la literatura legal. Se recopilaron todas las sentencias disponibles, y se evaluaron lo casos clínicos identificados por el grupo transdisciplinario de DDSs del Hospital Universitario San Ignacio. Finalmente, los autores generaron por consenso un texto de discusión, como guía para los lectores, luego de analizar cada una de las sentencias y los casos presentados.
Resultados Se identificaron 9 sentencias y los antecedentes que llevaron a la elaboración de cada una de ellas. Los nueve casos presentados contienen conceptos importantes para la articulación por parte del grupo transdisciplinario, tales como, autonomía, consentimiento sustituto y asistido, e indicación médica del tratamiento. Se excluyeron las sentencias T-692/99 y la T-918/2012, dado que daban información duplicada con referencia a sentencias incluidas en este documento.
Conclusión La Corte Constitucional Colombiana ha proferido sentencias en las cuales no se ha contado con la participación de grupos de expertos. La terminología usada no describe apropiadamente el lenguaje técnico que se aplica al manejo de nuestros pacientes. Para el abordaje de individuos con DDSs, resulta muy importante conocer la relevancia de las sentencias basadas en un análisis individual de cada caso.
Evaluation of Hindlimb Deformity and Posture in Dogs with Grade 2 Medial Patellar Luxation during Awake Computed Tomography Imaging while Standing
Authors: Tomo Yuma , Edamura Kazuya , Yamazaki Atsushi , Tanegashima Koji , Seki Mamiko , Asano Kazushi , Tinga Selena , Hayashi Kei 
Published: December 2021

Abstract
Objective The aim of this study was to determine the degree of bone deformities and hindlimb postural abnormalities in a standing position in awake Toy poodles with and without grade 2 medial patellar luxation (MPL) using high speed 320-row computed tomography (CT).
Methods The limbs with grade 2 MPL (MPL-G2 group) and without any orthopaedic disorders (control group) were imaged in a standing position, without sedation or anaesthesia, using CT. In MPL-G2 group, images were obtained when the patella was luxated (G2-L group) and reduced (non-luxation, G2-NL group). Bone morphologies of the femur and tibia were quantified three-dimensionally. Hindlimb standing posture was evaluated by measuring femoral rotation and abduction angles, tibial rotation angle, metatarsal rotation angle, foot rotation angle, angle between the femoral anatomical axis and the mechanical axis of hindlimb and stifle joint line convergence angle.
Results There were no significant differences in bone morphologic parameters between the MPL-G2 group (5 limbs) and the control group (6 limbs). In the G2-NL group, there were no significant hindlimb postural abnormalities. In contrast, in the G2-L group, significant hindlimb postural abnormalities including external rotation of femur, internal rotation of tibia and foot, external rotation of tarsal joint, large stifle joint convergence angle, genu varum and toe-in standing were observed.
Conclusion Dogs with grade 2 MPL have no bone deformities but show abnormal standing posture when the patella is luxated.