bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unusual plasmonic responses in phosphorene with topological transition: the interplay of strain and doping
Authors: Zhou Y , Chen M N , Zhao M D , Tang F , Shao C Q , Dai M Y 
Published: November 2021

Abstract
In this paper, plasmonic responses of phosphorene in the presence of strain and doping have been systematically investigated. Based on density functional theory, permittivities include both the intraband and interband transitions of electrons have been calculated. Due to the modification of the band structure, significantly higher Drude plasma frequency has been observed along the zigzag direction, other than the armchair direction as in the usual case. The resulting unusual plasmonic responses change their anisotropy, both in the elliptic as well as the hyperbolic regimes. Based on our calculations, positive strain as large as 5% along the zigzag direction can even lead to so-called reversed hyperbolic plasmonic responses. The k-surfaces of the plasmonic modes in extended monolayer have been analytically solved, and it is found that actively switching the topology (between elliptic and hyperbolic regimes) of the plasmonic responses by changing the Fermi level is possible in phosphorene at certain frequencies. In the end, a simple model has been proposed to describe such plasmonic responses in the infrared and the parameters of the model have been listed in tables which can be used directly in calculating the permittivities. Our studies may extend the scope of existing investigations of phosphorene plasmons and lead to band engineering as a way to control plasmons in two-dimensional materials.
Disruptive neoclassical tearing mode seeding in DIII-D with implications for ITER
Authors: La Haye R.J. , Chrystal C. , Strait E.J. , Callen J.D. , Hegna C.C. , Howell E.C. , Okabayashi M. , Wilcox R.S. 
Published: November 2021

Abstract
New studies identify the critical parameters and physics governing disruptive neoclassical tearing mode (NTM) onset. An m/n = 2/1 mode in DIII-D that begins to grow robustly after a seeding event (edge localized mode ELM or sawtooth precursor and crash) causes the mode rotation to drop close to the plasma’s E
r = 0 rest frame; this condition opens the stabilizing ion-polarization current ‘gate’ and destabilizes an otherwise marginally stable NTM. Our new experimental and theoretical insights and novel toroidal theory-based modeling are benchmarked and scalable to ITER and other future experiments. The nominal ITER rotation at q = 2 is found to be stabilizing (‘gate closed’) except for MHD-induced transients that could ‘open the gate’. Extrapolating from the DIII-D ITER baseline scenario (IBS) discharges, MHD transients are much more likely to destabilize problematic robustly growing 2/1 NTMs in ITER; this makes predictions of seeding and control of both ELMs and sawteeth imperative for more than just minimizing divertor pulsed-heat loading.
Studies on the role of ion mass and energy in the defect production in irradiation experiments in tungsten
Authors: Maya P.N. , Mukherjee S. , Sharma P. , Karki V. , Singh M. , Julie S. , Kikani P. , Satyaprasad A. , David C. , Pujari P.K. , Deshpande S.P. 
Published: November 2021

Abstract
Experimental investigations on the role of ion mass and the primary knock-on atoms (PKA) spectrum in the defect type, structure and defect production efficiency is presented in ion-irradiation experiments in tungsten using a combination of positron annihilation spectroscopy, transmission electron microscopy and secondary ion mass spectroscopy. Recrystallized tungsten foils were irradiated using low- (helium), medium- (boron) and high-mass (gold) ions of MeV energy for a comparable dpa and implantation range at room temperature. Depending on the ion mass and the PKA spectrum, distinctly different defect structures were observed at the atomistic as well as meso-scales. While no indication of dislocation lines was observed in 3 MeV helium irradiated samples, the boron and gold ions showed extensive dislocation line formation. The cluster shape depends on the PKA energy and the cluster density depends on the irradiation fluence. The depth profile analysis of the defects in the helium-irradiated samples showed extensive helium trapping throughout the implantation range. Significant sub-surface helium trapping is observed within 700 nm from the surface, indicating that they moved towards the surface from their mean implantation depth of 4500 nm. The study also shows a correlation between carbon and helium profiles in the samples.
International Symposium and International School for Young Scientists on “Physics, Engineering and Technologies for Biomedicine”
Authors: Kabashin A V , Klimentov S M , Timoshenko V Yu , Fronya A A 
Published: November 2021

Abstract
International Symposium and International School for Young Scientists on “Physics, Engineering and Technologies for Biomedicine” (PhysBioSymp) is an annually held event in National Research Nuclear University MEPhI (https://eng.mephi.ru/) (Moscow, Russia) since 2016. This symposium is conceived as the main conference of the Institute of Engineering Physics for Biomedicine (PhysBio, https://physbio.mephi.ru/), which is one of new strategic academic units founded in 2016 in the course of transformation of MEPhI from the technical to a global university in order to extend its portfolio toward life sciences, chemical and biomedical engineering. Following the chosen strategy, PhysBio aims at the advancement of its international reputation in biomedical sciences and technologies, as well as the integration of latest research achievements into the educational process in order to contribute to the solution of global problems, such as early diagnostics and efficient therapy of socially significant diseases, including cancer. Conceived as an essentially interdisciplinary institution, PhysBio is unique in combining powerful background of MEPhI in physics, mathematics, engineering, material sciences, nanotechnologies and expertise in new areas in chemistry and biology in order to develop breakthrough technologies for biomedical applications.
List of Committees are available in this pdf.
Strong light-matter coupling for optical switching through the fluorescence and FRET control
Authors: Nabiev I 
Published: November 2021

Abstract
Resonant interaction between excitonic transitions of molecules and localized electromagnetic field forms the hybrid polaritonic states. Tuneable microresonators may change the light-matter coupling strength and modulate them from weak to strong and ultra-strong coupling regimes. In this work we have realised strong coupling between the tuneable open-access cavity mode and the excitonic transitions in oligonucleotide-based molecular beacons with their terminus labelled with a pair of organic dye molecules demonstrating an efficient donor-to-acceptor Förster resonance energy transfer (FRET). We show that the predominant strong coupling of the cavity photon to the exciton transition in the donor dye molecule can lead to such a large an energy shift that the energy transfer from the acceptor exciton reservoir to the mainly donor lower polaritonic state can be achieved, thus yielding the chromophores’ donor–acceptor role reversal or “carnival effect”. The data show the possibility for confined electromagnetic fields to control and mediate polariton-assisted remote energy transfer. Obtained results open the avenues to quantum optical switching and other applications.
Comparison of pharmacokinetics and biodistribution of laser-synthesized plasmonic Au and TiN nanoparticles
Authors: Popov Anton A , Zelepukin Ivan V , Tikhonowski Gleb V , Popova-Kuznecova Elena A , Tselikov Gleb I , Al-Kattan Ahmed , Bailly Anne-Laure , Correard Florian , Braguer Diane , Esteve Marie-Anne , Klimentov Sergey M , Deyev Sergey M , Kabashin Andrei V 
Published: November 2021

AbstractPlasmonic nanostructures offer wide range of diagnostic and therapeutic functionalities for biomedical applications. Gold nanoparticles (Au NPs) present one of the most explored nanomaterial in this field, while titanium nitride nanoparticles (TiN NPs) is a new promising nanomaterial with superior plasmonic properties for biomedicine. However conventional chemical techniques for the synthesis of these nanomaterials cannot always match stringent requirements for toxicity levels and surface conditioning. Laser-synthesized Au and TiN NPs offer exceptional purity (no contamination by by-products or ligands) and unusual surface chemistry. Therefore, these NPs present a viable alternative to chemically synthesized counterparts. This work presents comparative analysis of pharmacokinetics and biodistribution of laser-synthesized 20 nm Au and TiN NPs under intravenous administration in mice model. Our data show that Au NPs and bare TiN NPs are rapidly eliminated from the blood circulation and accumulate preferentially in liver and spleen, while coating of TiN NPs by hydrophilic polymer polyethylene glycol (PEG) significantly prolongates blood circulation time and improves delivery of the NPs to tumor. We finally discuss potential applications of laser synthesized Au NPs in SERS, SEIRA and electrocatalysis, while TiN nanoparticles are considered as promising agents for photothermal therapy and photoacoustic imaging.
MIL-53 (Al) metal-organic frameworks as potential drug carriers
Authors: Griaznova O Yu , Zelepukin I V , Tikhonowski G V , Kolokolnikov V N , Deyev S M 
Published: November 2021

Abstract
One of the challenges of the medicine is to improve the chemical stability of drugs and to prevent their premature biodegradation before reaching the therapeutic target. Various nanoparticles were used to solve this problem, but low drug loading efficiency limited their biomedical applications. Metal organic frameworks are promising candidates for drug delivery since they have extremely high surface area and regular porosity. In this study, we prepared high-crystalline MIL-53 frameworks based on aluminium and 2-aminoterephtalic acid by microwave-assisted synthesis and evaluated their properties as drug carriers. Drug loading of chemotherapeutic and diagnostic molecules of different nature riches value of 34% by particle weight, significantly higher than those of other reported solid nanoparticles. Therefore, our results make MIL-53 (Al) frameworks promising candidate for drug delivery.
Small-angle X-ray (SAXS) and Raman spectroscopy studies of biot-CMG(2)-DOPE quasicrystalline phases
Authors: Maslennikov A M , Zalygin A V , Shtykova E V , Bovin N V , Oleinikov V A 
Published: November 2021

Abstract
Neoglycolipids due to their amphiphilic properties exhibit self-assembly in aqueous phases. In high concentrations the liquid crystalline or gel phases may form. So-called soft-material are a subject of interest of many scientists especially as biosensors and wound healing materials. In this study we examine the structure of a quasicrystalline phase of biot-CMG(2)-DOPE obtained at the concentration of 150 mg/ml (13wt.%) in PBS. The structural data such as interplanar spacing, order parameter and long-range order were obtained by SAXS, while the changes in chemical structure were studied by Raman spectroscopy. It was also in our interest to examine a correlation between the ionic strength and the self-assembly, so we also studied a similar quasicrystalline phase of the same compound but in a buffer containing CaCl2 at the concentration of 4wt.%. According to SAXS data, FSL-biotin construct formed a complex ordered phase consisting of overlapping latices of different kind. The addition of CaCl2 into PBS resulted in obtaining a more structured system demonstrating cubic-like crystal lattice. Change in peak intensities on Raman spectrums of -C-H- and -C-C- bonds vibrations explained the change in phase properties.
Effect of electrolyte conductivity and local electric field inhomogeneity on heating of an aqueous suspension of solid-state nanoparticles
Authors: Grigoriev A A , Zavestovskaya I N , Kargina Yu V , Kharin A Yu , Kanavin A P , Timoshenko V Yu 
Published: November 2021

Abstract
This work theoretically investigates the process of heat release in an electrolyte near a solid-state nanoparticle when exposed to an external radio-frequency electromagnetic field. The effect on the heat release of the effect of a change in the electrical conductivity of the electrolyte near the nanoparticle due to the redistribution of the ion concentration and the inhomogeneity of the electric field caused by the difference in the dielectric constants of the electrolyte and the nanoparticle is taken into account. The proposed model can be useful for choosing the optimal parameters of nanoparticles and radio frequency radiation when used in biomedicine for tumor hyperthermia.
Fluorescence diagnostics and photodynamic therapy of squamous cell carcinoma of the lateral surface of the tongue using the photosensitizer chlorin e6 by spectroscopic video fluorescence methods
Authors: Kulichenko A , Farrakhova D S , Yakovlev D V , Maklygina Yu S , Shiryaev A A , Loschenov V B 
Published: November 2021

Abstract
This paper presents the results of using intraoperative fluorescence diagnostics (FD) with the endoscopic video system to increase the efficiency of photodynamic therapy (PDT). The molecular form of chlorin e6 was used as a photosensitizer (PS). All patients received an intravenous administration drug based on chlorin e6 at the concentration of 1 mg/kg. Diagnostics and therapy were carried out in 4 patients diagnosed by malignant neoplasms of the lateral surface of the tongue. Determination of the boundaries by changing the signal of the fluorescence intensity of the tumor was carried out before PDT and after PDT. The efficiency of PDT was assessed by the fluorescent signal of the tumor decreasing when compared with non-pathological normal tissue. The FD method allows to determine accurately the actual size of the tumor and its borders. All patients underwent PDT influenced by the therapeutic laser with a generation wavelength of 660 nm. It is shown that the using of fluorescence diagnostics improves the quality of the photodynamic therapy, since it is possible to assess the photobleaching of the drug during the operation.
Laser-based inactivation of pathogenic microorganisms
Authors: Shelygina S N , Kompanets V O , Saraeva I N , Tolordava E R , Kudryashov S I , Rupasov A E , Baitsaeva O I , Zayarniy D A , Savinov M S , Chekalin S V , Ionin A A 
Published: November 2021

Abstract
In the context of studying the possibility of inactivation of pathogenic microorganisms, the dynamic transmission spectra of femtosecond laser radiation in the mid-IR range by bacteria of the Pseudomonaus aeruginosa culture planted on a silicon substrate were investigated. Irradiation revealed a blue shift in the characteristic absorption bands of bacteria, indicating the breaking of hydrogen bonds responsible for the formation of the secondary and tertiary structure of the proteins.
Optical biopsy: fundamentals and applications in neurosurgery
Authors: Savelieva T A , Romanishkin I D , Maklygina Yu S , Grachev P V , Kalyagina N A , Borodkin A V , Orlov A V , Tsarukaev B A , Aristov A A , Kosyrkova A V , Goryajnov S A , Shugaj S V , Shishkina L V , Potapov A A , Loschenov V B 
Published: November 2021

AbstractCurrently, there is a significant increase in the incidence of cancer of the central nervous system. Determination of the boundaries of intracerebral and intramedullary tumors is especially difficult. The urgency of the problem of determining the boundaries of astrocytic tumors is due to the peculiarities of their growth along myelinated nerve fibers and vessels, leading to the infiltration of healthy white matter by tumor cells, which affects the high frequency of postoperative relapses. The complexity of surgery for intramedullary tumors of the spinal cord is that the tumor does not always have a clear border and the risk of injury is high due to the smaller size of the operated area compared to the brain. Reliable information regarding the volume of the resected tumor should be obtained by intraoperative imaging. The solution to this problem is implemented mainly in three directions: the use of intraoperative computed tomography, magnetic resonance imaging and ultrasound scanning, and various combinations of these methods. Unfortunately, all these methods of intraoperative diagnostics do not allow real-time examination of tissues in an operating wound and/or do not provide a simultaneous analysis of both structural and metabolic changes. The limitations of intraoperative navigation methods in neurosurgery have led to the relevance of the development of an accurate spectroscopic method for in vivo determination of the content of specific metabolic markers and structural changes accompanying the development of the tumor process in the nervous tissue. Various approaches to intraoperative navigation based on optical spectroscopy are called optical biopsy. In this article, we present the methods and tools developed in recent years for spectroscopic guidance in neurooncology. First of all, this, of course, concerns the analysis of spectral dependences recorded before, during and after tumor removal. We have used such modalities of optical spectroscopy as fluorescence, diffuse reflectance spectroscopy and spontaneous Raman scattering. An equally important issue on the way to increasing the efficiency of tumor resection is the development of new instrumentation; therefore, we have developed a number of new devices, which are a combination of well-known neurosurgical instruments and laser and fiber-optic technologies. Last but not least is the issue of rapid classification of the studied tissues based on the recorded signals, which was solved by us using machine learning methods.
Application of atomic force microscopy in biology and medicine
Authors: Nikitaev V G , Pronichev A N , Markov T K , Esaulov N 
Published: November 2021

Abstract
This article presents the main areas of application of atomic force microscopy in biology and medicine, describes the principle of an atomic force microscope and the main modes of its operation. The works and results of the leading laboratories in the stated topic are considered. There are a number of proposals for generalizing the considered results into a unified knowledge base on diseases and the general state of health of the human body.
Brain–computer interface technologies for monitoring and control of bionic systems
Authors: Berestov R M , Bobkov E A , Belov V S , Nevedin A V 
Published: November 2021

Abstract
At the moment, neurocomputer interfaces (BCI) make it possible to implement on their basis devices for diagnosing a physical condition, implementing control systems for bionic prostheses, information input means such as neuro chat and character set systems based on brain potentials. At the moment, the main technology for obtaining brain activity for neurointerfaces is the electroencephalogram (EEG). There are promising technologies that will make it possible to achieve new results in the field of neurointerfaces. These technologies are functional near infrared spectroscopy (fNIRS) and magnetoencephalography (MEG).
Integrated information and measurement system for the diagnosis of acute leukemia and minimal residual disease based on computer microscopy, flow laser cytofluorimetry and artificial intelligence
Authors: Nikitayev V G , Pronichev A N , Tupitsin N N , Selchuk V Yu , Dmitrieva V V , Palladina A D , Polyakov E V , Liberis K A , Tsyplyak V I 
Published: November 2021

Abstract
The article considers a new integrated information and measurement system for the diagnosis of acute leukemia and minimal residual disease based on computer microscopy and flow laser cytometry. The system is based on combining the results of computer microscopy in the analysis of bone marrow preparations and the results of flow laser cytofluorimetry. A special feature of the system is the use of artificial intelligence technologies in the recognition of images of bone marrow cells in the computer microscopy subsystem. The work was the result of joint work of the Department of Computer Medical Systems of the National Research Nuclear University "MEPhI" and the Laboratory of Hematopoietic Immunology of the National Medical Research Center of Oncology named after N. N. Blokhin.
Biodistribution of phenylalanine labeled with gallium-68
Authors: Tishchenko V K , Petriev V M , Stepchenkova E D 
Published: November 2021

Abstract
Positron emission tomography (PET) is modern high sensitivity method of various tumor imaging. The synthesis of new radiopharmaceuticals based on amino acids and positron emitting radionuclide 68Ga for PET imaging is of great interest. This work is devoted to study the biodistribution of a new agent based on amino acid phenylalanine and 68Ga (68Ga-phenylalanine) in Wistar rats with cholangioma RS-1 after intravenous administration. A comparative investigation of 68Ga-phenylalanine and 68GaCl3 biodistribution was also carried out. It was shown that the highest uptake of 68Ga-phenylalanine was observed in blood, liver, femur and tumor. Tumor uptake of 68Ga-phenylalanine increased 3.5 times from 0.20 ± 0.03 % ID/g to 0.70 ± 0.10 % ID/g, whereas uptake of 68GaCl3 decreased from 0.34 ± 0.07 % ID/g to 0.13 ± 0.04 % ID/g within 3 h. Blood uptake of 68Ga-phenylalanine reached 2.98 ± 0.31 % ID/g. In other organs and tissues the uptake of 68Ga-phenylalanine didn’t exceed 1 % ID/g. Kidneys and femur uptake of 68Ga-phenylalanine was lower as compared with 68GaCl3, but in other organs the uptake of 68Ga-phenylalanine was similar or slightly higher when compared with 68GaCl3.
The influence of temperature on biodistribution of N,N,N’,N’- ethylenediaminetetrakis(methylene phosphonic) acid labeled with gallium-68
Authors: Tishchenko V K , Petriev V M , Stepchenkova E D , Shegai P V , Ivanov S A , Kaprin A D 
Published: November 2021

Abstract
Bone metastases are serious complication in the progression of various types of cancer. It determines the requirement of modern nuclear diagnostic tools, including positron emission tomography (PET). In this study the biodistribution of EDTMP labeled with gallium-68 (68Ga-EDTMP) prepared at different temperature (20, 50, and 95 °C) was investigated. All experimental studies were performed in healthy intact Wistar rats by measuring the radioactivity in organs and tissues with gamma counter. All 68Ga-EDTMP formulations accumulated predominantly in bones. Only in tibia the uptake of 68Ga-EDTMP prepared at 95 °C was higher (p < 0.05) than 68Ga-EDTMP prepared at 20 °C, but in other bones there weren’t any statistical differences in uptake of 68Ga-EDTMP formulations. The amounts of 68Ga-EDTMP formulations in soft organs and tissues were lower when compared with bones. In conclusion, a temperature of reaction mixture had an influence on the biodistribution of 68Ga-EDTMP in bones.
Classification of bone marrow cells in the diagnosis of acute lymphoblastic leukemia
Authors: Nikitayev V G , Pronichev A N , Tupitsin N N , Selchuk V Yu , Dmitrieva V V , Palladina A D , Polyakov E V , Liberis K A , Dzhokich M , Solomatin M A , Nosova E M 
Published: November 2021

Abstract
The paper presents approaches to automated classification of bone marrow cells in the diagnosis of acute lymphoblastic leukemia and minimal residual disease using image recognition procedures. The classification methods that show the best accuracy in the recognition of eight types of bone marrow cells were experimentally determined. Recommendations for their use are given.