bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-resolution pediatric age–specific 18F-FDG PET template: a pilot study in epileptogenic focus localization
Authors: Zhang Teng , Li Yuting , Zhao Shuilin , Xu Yuanfan , Zhang Xiaohui , Wu Shuang , Dou Xiaofeng , Yu Congcong , Feng Jianhua , Ding Yao , Zhu Junming , Chen Zexin , Zhang Hong , Tian Mei 
Published: November 2021

Abstract
Background
PET imaging has been widely used in diagnosis of neurological disorders; however, its application to pediatric population is limited due to lacking pediatric age–specific PET template. This study aims to develop a pediatric age–specific PET template (PAPT) and conduct a pilot study of epileptogenic focus localization in pediatric epilepsy.

Methods
We recruited 130 pediatric patients with epilepsy and 102 age-matched controls who underwent 18F-FDG PET examination. High-resolution PAPT was developed by an iterative nonlinear registration-averaging optimization approach for two age ranges: 6–10 years (n = 17) and 11–18 years (n = 50), respectively. Spatial normalization to the PAPT was evaluated by registration similarities of 35 validation controls, followed by estimation of potential registration biases. In a pilot study, epileptogenic focus was localized by PAPT-based voxel-wise statistical analysis, compared with multi-disciplinary team (MDT) diagnosis, and validated by follow-up of patients who underwent epilepsy surgery. Furthermore, epileptogenic focus localization results were compared among three templates (PAPT, conventional adult template, and a previously reported pediatric linear template).

Results
Spatial normalization to the PAPT significantly improved registration similarities (P < 0.001), and nearly eliminated regions of potential biases (< 2% of whole brain volume). The PAPT-based epileptogenic focus localization achieved a substantial agreement with MDT diagnosis (Kappa = 0.757), significantly outperforming localization based on the adult template (Kappa = 0.496) and linear template (Kappa = 0.569) (P < 0.05). The PAPT-based localization achieved the highest detection rate (89.2%) and accuracy (80.0%). In postsurgical seizure-free patients (n = 40), the PAPT-based localization also achieved a substantial agreement with resection areas (Kappa = 0.743), and the highest detection rate (95%) and accuracy (80.0%).

Conclusion
The PAPT can significantly improve spatial normalization and epileptogenic focus localization in pediatric epilepsy. Future pediatric neuroimaging studies can also benefit from the unbiased spatial normalization by PAPT.
Trial registration.
NCT04725162: https://clinicaltrials.gov/ct2/show/NCT04725162
MRI grading for the prediction of prostate cancer aggressiveness
Authors: Boschheidgen M. , Schimmöller L. , Arsov C. , Ziayee F. , Morawitz J. , Valentin B. , Radke K. L. , Giessing M. , Esposito I. , Albers P. , Antoch G. , Ullrich T. 
Published: November 2021

Abstract
Objectives
T
o evaluate the value of multiparametric MRI (mpMRI) for the prediction of prostate cancer (PCA) aggressiveness.

Methods
In this single center cohort study, consecutive patients with histologically confirmed PCA were retrospectively enrolled. Four different ISUP grade groups (1, 2, 3, 4–5) were defined and fifty patients per group were included. Several clinical (age, PSA, PSAD, percentage of PCA infiltration) and mpMRI parameters (ADC value, signal increase on high b-value images, diameter, extraprostatic extension [EPE], cross-zonal growth) were evaluated and correlated within the four groups. Based on combined descriptors, MRI grading groups (mG1–mG3) were defined to predict PCA aggressiveness.

Results
In total, 200 patients (mean age 68 years, median PSA value 8.1 ng/ml) were analyzed. Between the four groups, statistically significant differences could be shown for age, PSA, PSAD, and for MRI parameters cross-zonal growth, high b-value signal increase, EPE, and ADC (p < 0.01). All examined parameters revealed a significant correlation with the histopathologic biopsy ISUP grade groups (p < 0.01), except PCA diameter (p = 0.09). A mixed linear model demonstrated the strongest prediction of the respective ISUP grade group for the MRI grading system (p < 0.01) compared to single parameters.

Conclusions
MpMRI yields relevant pre-biopsy information about PCA aggressiveness. A combination of quantitative and qualitative parameters (MRI grading groups) provided the best prediction of the biopsy ISUP grade group and may improve clinical pathway and treatment planning, adding useful information beyond PI-RADS assessment category. Due to the high prevalence of higher grade PCA in patients within mG3, an early re-biopsy seems indicated in cases of negative or post-biopsy low-grade PCA.

Key Points
• MpMRI yields relevant pre-biopsy information about prostate cancer aggressiveness.
• MRI grading in addition to PI-RADS classification seems to be helpful for a size independent early prediction of clinically significant PCA.
• MRI grading groups may help urologists in clinical pathway and treatment planning, especially when to consider an early re-biopsy.
Role of convection–circulation coupling in the propagation mechanism of the Madden–Julian Oscillation over the Maritime Continent in a climate model
Authors: Wang Yi-Chi , Tseng Wan-Ling , Hsu Huang-Hsiung 
Published: November 2021

AbstractThis study investigates the role of convection–circulation coupling on the simulated eastward propagation of the Madden–Julian Oscillation (MJO) over the Maritime Continent (MC). Experiments are conducted with the European Centre Hamburg Model Version 5 (ECHAM5) coupled with the one-column ocean model—Snow-Ice-Thermocline (SIT) and two different cumulus schemes, Nordeng-Tiedtke (E5SIT-Nord) and Tiedtke (E5SIT-Tied). During the early phase of MJO composites, the E5SIT-Nord simulation reveals stronger intraseasonal anomalies in the apparent heat source (Q1) over the convective center, however, the E5SIT-Tied produces a stronger background Q1, suggesting that deep convection prevails over the MC but does not couple with the MJO circulation. Similarly, in the E5SIT-Tied simulation, in-column moisture is kept mostly by local deep convection over the MC, which is in contrast to the well-correlated relationship between moisture anomaly and MJO circulation in E5SIT-Nord. A case study based on an observational MJO reveals similar biases concerning of convection–circulation coupling emerges within a few days of simulations. The E5SIT-Tied simulation produces weaker heating at the convective center of the MJO than the E5SIT-Nord a few days after model initiation, resulting weaker subsidence to the east and less favorable for propagation. The present findings highlight the instantaneous responses of cumulus parameterization schemes to MJO-related environmental changes can further affect intraseasonal variability through altering convection–circulation coupling over the MC. Physical schemes of moist convection are essential to realistically represent this coupling and thereby improve the simulation of the eastward propagation of the MJO.
Institutional persistence despite cultural change: a historical case study of the re-categorization of dogs in Germany
Authors: Pfau-Effinger Birgit , Sebastian Marcel 
Published: November 2021

AbstractHuman–animal relations in post-industrial societies are characterized by a system of cultural categories that distinguishes between different types of animals based on their function in human society, such as “farm animals” or “pets.” The system of cultural categories, and the allocation of animal species within this cultural classification system can change. Options for change include re-categorizing a specific animal species within the categorical system. The paper argues that attempts by political actors to adapt the institutional system to cultural change that calls for re-categorization of certain animal species can start a contradictory process that may lead to long-term survival of the respective institution despite the cultural change. It is common to explain the persistence of political institutions with institutional path dependency or policy preferences of the governing parties. This paper introduces a new institutional theoretical approach to the explanation, the approach of “rejecting changing a part for fear of undermining the whole.” This paper uses a case study of a series of failed political efforts to change the treatment of dogs in the framework of the agricultural human–animal policy in the Federal Republic of Germany in the second half of the twentieth century, to evaluate its theoretical argument, using analyses of historical political documents, mass media, and communication documents between civil society actors and policymakers. This paper makes an innovative contribution to the theory and research on institutional change, the sociology of agriculture and food, and the sociology of human–animal relations.
Algorithmic disclosure rules
Authors: Di Porto Fabiana 
Published: November 2021

AbstractDuring the past decade, a small but rapidly growing number of Law&Tech scholars have been applying algorithmic methods in their legal research. This Article does it too, for the sake of saving disclosure regulation failure: a normative strategy that has long been considered dead by legal scholars, but conspicuously abused by rule-makers. Existing proposals to revive disclosure duties, however, either focus on the industry policies (e.g. seeking to reduce consumers’ costs of reading) or on rulemaking (e.g. by simplifying linguistic intricacies). But failure may well depend on both. Therefore, this Article develops a `comprehensive approach', suggesting to use computational tools to cope with linguistic and behavioral failures at both the enactment and implementation phases of disclosure duties, thus filling a void in the Law & Tech scholarship. Specifically, it outlines how algorithmic tools can be used in a holistic manner to address the many failures of disclosures from the rulemaking in parliament to consumer screens. It suggests a multi-layered design where lawmakers deploy three tools in order to produce optimal disclosure rules: machine learning, natural language processing, and behavioral experimentation through regulatory sandboxes. To clarify how and why these tasks should be performed, disclosures in the contexts of online contract terms and privacy online are taken as examples. Because algorithmic rulemaking is frequently met with well-justified skepticism, problems of its compatibility with legitimacy, efficacy and proportionality are also discussed.
Radioactive isotopes in the interstellar medium
Authors: Diehl Roland 
Published: November 2021

AbstractRadioactive components of the interstellar medium provide an entirely-different and new aspect to the studies of the interstellar medium. Injected from sources of nucleosynthesis, unstable nuclei decay along their trajectories. Measurements can occur through characteristic gamma rays that are emitted with the decay, or in cosmic material samples through abundances of parent and daughter isotopes as they change with decay. The dynamics and material flows within interstellar medium are thus accessible to measurement, making use of the intrinsic clock that radioactive decay provides. We describe how measurements of radioactive decay have obtained a break-through in studies of the interstellar medium, after first summarizing the characteristics of radioactivity and the sources of unstable nuclei.
Estimated lifetime risk of venous thromboembolism in men and women in a Danish nationwide cohort: impact of competing risk of death
Authors: Arnesen Carl Arne Løchen , Veres Katalin , Horváth-Puhó Erzsébet , Hansen John-Bjarne , Sørensen Henrik Toft , Brækkan Sigrid K. 
Published: November 2021

AbstractIncidence of venous thromboembolism (VTE) risk varies by age and sex. Some studies have reported overall higher risk in men, especially when VTEs triggered by female reproductive factors are excluded. However, higher mortality rates in men may have led to overestimation of lifetime VTE risk in men compared with women. Therefore, we estimated the lifetime risk of VTE in men and women in a Danish, nationwide cohort, taking into account the competing risk of death. Within the population of Denmark (> 5 million persons), all first-time VTEs occurring in 1995–2016 were identified from the Danish National Patient Registry covering all Danish hospitals. The cumulative incidences of VTE were estimated in men and women with age as timescale, taking into account the competing risk of death. Estimated lifetime risk was defined as cumulative incidence at age 100. In a simulation study, we excluded the proportion of female cases that could be attributed to reproductive risk factors and re-estimated the cumulative incidence. We identified 123,543 incident VTEs. The cumulative incidence of VTE was 1.9% in women and 1.3% in men at age 50, 4.3% in women and 4.4% in men at age 70, and 9.3% in women and 8.1% in men at age 100. After accounting for VTEs attributed to reproductive factors, the corresponding incidences in women were 1.2% at age 50, 3.2% at age 70, and 8.2% at age 100. In conclusion, the estimated lifetime risk of VTE was slightly higher in women than in men when accounting for competing risk of death. Our simulation study suggested that reproductive risk factors contribute modestly to the estimated lifetime VTE risk in women.
Exploration of a singular fluid spacetime
Authors: Remmen Grant N. 
Published: November 2021

AbstractWe investigate the properties of a special class of singular solutions for a self-gravitating perfect fluid in general relativity: the singular isothermal sphere. For arbitrary constant equation-of-state parameter $$w=p/\rho $$

w
=
p
/
ρ

, there exist static, spherically-symmetric solutions with density profile $$\propto 1/r^2$$

∝
1
/

r
2

, with the constant of proportionality fixed to be a special function of w. Like black holes, singular isothermal spheres possess a fixed mass-to-radius ratio independent of size, but no horizon cloaking the curvature singularity at $$r=0$$

r
=
0

. For $$w=1$$

w
=
1

, these solutions can be constructed from a homogeneous dilaton background, where the metric spontaneously breaks spatial homogeneity. We study the perturbative structure of these solutions, finding the radial modes and tidal Love numbers, and also find interesting properties in the geodesic structure of this geometry. Finally, connections are discussed between these geometries and dark matter profiles, the double copy, and holographic entropy, as well as how the swampland distance conjecture can obscure the naked singularity.
Measurement Invariance of the Brief Resilient Coping Scale (BRCS) in Peruvian and Spanish Older Adults
Authors: Tomas Jose M. , Caycho-Rodríguez Tomás , Ventura-León José , Sancho Patricia , García Cirilo H. , Arias Walter L. 
Published: November 2021

AbstractAlthough the Brief Resilient Coping Scale (BRCS) has been validated in some European and American countries, there are no studies that evaluate its factorial invariance among different nations. In this sense, the objective of the study is to evaluate the factorial invariance of the BRCS in samples of older adults in Peru and Spain, using multigroup Confirmatory Factor Analysis. 236 older adults from Peru participated (Mean age = 72.8, SD = 6.90) and 133 older adults from Spain (Mean age = 71, SD = 7). In the Peruvian sample 78.4% were women and 21.6% men; while in the Spanish sample the majority were women (69.9%). The BRCS was scalar invariant but not strictly invariant between Spain and Peru. Our results found invariance of the structure, factor loadings and intercepts in both countries. These results support the use of BRCS in studies that compare the resilience between samples of older adults in both countries, and encourage applied research for the development of resilience in older adults in Spain and Peru.
In situ microstructure analysis of Inconel 625 during laser powder bed fusion
Authors: Schmeiser Felix , Krohmer Erwin , Wagner Christian , Schell Norbert , Uhlmann Eckart , Reimers Walter 
Published: November 2021

AbstractLaser powder bed fusion is an additive manufacturing process that employs highly focused laser radiation for selective melting of a metal powder bed. This process entails a complex heat flow and thermal management that results in characteristic, often highly textured microstructures, which lead to mechanical anisotropy. In this study, high-energy X-ray diffraction experiments were carried out to illuminate the formation and evolution of microstructural features during LPBF. The nickel-base alloy Inconel 625 was used for in situ experiments using a custom LPBF system designed for these investigations. The diffraction patterns yielded results regarding texture, lattice defects, recrystallization, and chemical segregation. A combination of high laser power and scanning speed results in a strong preferred crystallographic orientation, while low laser power and scanning speed showed no clear texture. The observation of a constant gauge volume revealed solid-state texture changes without remelting. They were related to in situ recrystallization processes caused by the repeated laser scanning. After recrystallization, the formation and growth of segregations were deduced from an increasing diffraction peak asymmetry and confirmed by ex situ scanning transmission electron microscopy.
Graphical Abstract
Exploring Associations Between Self-Compassion, Self-Criticism, Mental Health, and Quality of Life in Adults with Cystic Fibrosis: Informing Future Interventions
Authors: Kauser S. , Keyte R. , Regan A. , Nash E. F. , Fitch G. , Mantzios M. , Egan H. 
Published: November 2021

AbstractSelf-compassion is increasingly recognised as an important and beneficial factor in quality of life and mental health-related research, but research within the adult cystic fibrosis (CF) population is scarce. In a cross-sectional study, 114 (56 female, 58 male) adults with CF completed and returned a series of validated questionnaires that assessed CF-related quality of life, negative emotional states (depression, anxiety and stress), self-compassion, and self-criticism. Quality of life and self-compassion were positively correlated, and each in turn were inversely correlated with negative emotional states and self-criticism. Negative emotional states correlated positively to self-criticism. Self-compassion and/or self-criticism moderated ten relationships between various sub-domains of quality of life and negative emotions. Psychological interventions that increase self-compassion may be beneficial for enhancing mental health and quality of life for adults with CF.
Youth solving pandemics: hopeful futures in Maths Claesson’s novel Pandemic
Authors: Ehriander Helene , Godhe Michael 
Published: November 2021

AbstractAre representations of pandemics in fiction always bleak dystopian tales understood as nature’s revenge on the modern Faustian man, or could they also express hope and expand our imagination in a time of environmental crisis? In this article, we analyse the young adult novel Pandemic (Swedish title: Pandemi, 2018) by Swedish author Maths Claesson. Pandemic is the third novel in a trilogy (2013–2018) with 15-year-old astronaut-trainee Linux as the main protagonist. During his astronaut program on a space station, a pandemic breaks out on Earth. While scientists on Earth struggle to isolate the virus and find a vaccine, Linux and his fellow astronaut-trainees are asked by the WHO to try out a simulation, a computer game aimed at isolating a pandemic outbreak and finding a vaccine. Their simulation is successful and eventually becomes decisive for the solution of the current pandemic crisis on Earth. Departing from Critical Future Studies (Goode and Godhe, Cult Unbound J Curr Cul Res 9(1):108–129, 2017), we focus on the figures of hope (cf. Moylan, Demand the impossible: Science fiction and the utopian imagination, Methuen, pp. 1–2, 1986) for a sustainable future and analyse how the novel is widening the scopes of possible futures. We show how the computer simulation and the successful solution of the crisis serves as a vehicle for a broader discussion about what kind of future we want, a future where the conquest of space offers new opportunities, e.g. for solving the environmental crisis. While normally in Y/A speculative fiction, technology is almost exclusively depicted as ostensibly serving human needs, in Pandemic it is thanks to technology, and the younger generation’s particular skills, that the disease is conquered. In this sense, the novel is hopeful since it depicts the younger generation as being capable of developing different thinking patterns from those of the adult society.
A study of defect-based error estimates for the Krylov approximation of φ-functions
Authors: Jawecki Tobias 
Published: November 2021

AbstractPrior recent work, devoted to the study of polynomial Krylov techniques for the approximation of the action of the matrix exponential etAv, is extended to the case of associated φ-functions (which occur within the class of exponential integrators). In particular, a posteriori error bounds and estimates, based on the notion of the defect (residual) of the Krylov approximation are considered. Computable error bounds and estimates are discussed and analyzed. This includes a new error bound which favorably compares to existing error bounds in specific cases. The accuracy of various error bounds is characterized in relation to corresponding Ritz values of A. Ritz values yield properties of the spectrum of A (specific properties are known a priori, e.g., for Hermitian or skew-Hermitian matrices) in relation to the actual starting vector v and can be computed. This gives theoretical results together with criteria to quantify the achieved accuracy on the fly. For other existing error estimates, the reliability and performance are studied by similar techniques. Effects of finite precision (floating point arithmetic) are also taken into account.
China’s technological performance as reflected in patents
Authors: Schmoch Ulrich , Gehrke Birgit 
Published: November 2021

AbstractVarious concepts for the comparison of countries by patent indicators have been developed for the comparison of countries based on patent indicators. These concepts are generally based on the application of patents in several important markets or the family size of patent applications. A specific observation is the limited transfer of PCT applications of Chinese origin, affecting all these concepts. Transnational patents prove to be a convenient and appropriate tool for making country comparisons by technology, particularly with respect to adequately consider China’s specific patent behaviour. Therefore the phenomenon of limited transfer of China’s PCT applications is analysed for transnational patents. This observation can be associated with lower patent values or with a decreasing export dynamic. The Chinese transfer rates vary considerably by technology as well as by the reason for lower transfer rates. It proves to be more adequate to take limited transfer rates into account.