bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual PD-1 and CTLA-4 Checkpoint Blockade Using Balstilimab and Zalifrelimab Combination as Second-Line Treatment for Advanced Cervical Cancer: An Open-Label Phase II Study
Authors: O'Malley David M. , Neffa Maryna , Monk Bradley J. , Melkadze Tamar , Huang Marilyn , Kryzhanivska Anna , Bulat Iurie , Meniawy Tarek M. , Bagameri Andrea , Wang Edward W. , Doger de Speville Uribe Bernard , Hegg Roberto , Ortuzar Feliu Waldo , Ancukiewicz Marek , Lugowska Iwona 
Published: December 2021

PURPOSE Balstilimab (antiprogrammed death-1) and zalifrelimab (anticytotoxic T-lymphocyte–associated antigen-4) are two new checkpoint inhibitors emerging as promising investigational agents for the treatment of advanced cervical cancer. This phase II trial (ClinicalTrials.gov identifier: NCT03495882 ) evaluated the combination of balstilimab plus zalifrelimab in patients with recurrent and/or metastatic cervical cancer who relapsed after prior platinum-based therapy. PATIENTS AND METHODS Patients were intravenously dosed with balstilimab 3 mg/kg once every 2 weeks and zalifrelimab 1 mg/kg once every 6 weeks, for up to 24 months. The primary end point was objective response rate (ORR, RECIST version 1.1, assessed by independent central review). Secondary end points included duration of response, safety and tolerability, and survival. RESULTS In total, 155 women (median age, 50 years [range, 24-76 years]) were enrolled and treated with balstilimab plus zalifrelimab; 125 patients had measurable disease at baseline and one prior line of platinum-based therapy in the advanced setting, and these patients constituted the efficacy-evaluable population. The median follow-up was 21 months. The confirmed ORR was 25.6% (95% CI, 18.8 to 33.9), including 10 complete responders and 22 partial responders, with median duration of response not reached (86.5%, 75.5%, and 64.2% at 6, 9, and 12 months, respectively). The ORRs were 32.8% and 9.1% in patients with programmed death ligand-1–positive and programmed death ligand-1–negative tumors, respectively. For patients with squamous cell carcinoma, the ORR was 32.6%. The overall disease control rate was 52% (95% CI, 43.3 to 60.6). Hypothyroidism (14.2%) and hyperthyroidism (7.1%) were the most common immune-mediated adverse events. CONCLUSION Promising and durable clinical activity, with favorable tolerability, was seen in this largest trial to date evaluating dual programmed death-1/cytotoxic T-lymphocyte–associated antigen-4 blockade in patients with recurrent and/or metastatic cervical cancer. Further investigation of the balstilimab and zalifrelimab combination in this setting is continuing.
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline
Authors: Vogelbaum Michael A. , Brown Paul D. , Messersmith Hans , Brastianos Priscilla K. , Burri Stuart , Cahill Dan , Dunn Ian F. , Gaspar Laurie E. , Gatson Na Tosha N. , Gondi Vinai , Jordan Justin T. , Lassman Andrew B. , Maues Julia , Mohile Nimish , Redjal Navid , Stevens Glen , Sulman Erik , van den Bent Martin , Wallace H. James , Weinberg Jeffrey S. , Zadeh Gelareh , Schiff David 
Published: December 2021

PURPOSE To provide guidance to clinicians regarding therapy for patients with brain metastases from solid tumors. METHODS ASCO convened an Expert Panel and conducted a systematic review of the literature. RESULTS Thirty-two randomized trials published in 2008 or later met eligibility criteria and form the primary evidentiary base. RECOMMENDATIONS Surgery is a reasonable option for patients with brain metastases. Patients with large tumors with mass effect are more likely to benefit than those with multiple brain metastases and/or uncontrolled systemic disease. Patients with symptomatic brain metastases should receive local therapy regardless of the systemic therapy used. For patients with asymptomatic brain metastases, local therapy should not be deferred unless deferral is specifically recommended in this guideline. The decision to defer local therapy should be based on a multidisciplinary discussion of the potential benefits and harms that the patient may experience. Several regimens were recommended for non–small-cell lung cancer, breast cancer, and melanoma. For patients with asymptomatic brain metastases and no systemic therapy options, stereotactic radiosurgery (SRS) alone should be offered to patients with one to four unresected brain metastases, excluding small-cell lung carcinoma. SRS alone to the surgical cavity should be offered to patients with one to two resected brain metastases. SRS, whole brain radiation therapy, or their combination are reasonable options for other patients. Memantine and hippocampal avoidance should be offered to patients who receive whole brain radiation therapy and have no hippocampal lesions and 4 months or more expected survival. Patients with asymptomatic brain metastases with either Karnofsky Performance Status ≤ 50 or Karnofsky Performance Status < 70 with no systemic therapy options do not derive benefit from radiation therapy. Additional information is available at www.asco.org/neurooncology-guidelines .
Application of urine immunofixation electrophoresis in prognostic evaluation of hematopoietic stem cell transplantation in patients with myeloma
Authors: Zhu Shanshan , Yang Chao , Li Wei , Lin Meilin 
Published: December 2021

Objectives: To investigate the value of urine immunofixation electrophoresis in prognostic evaluation of hematopoietic stem cell transplantation in patients with myeloma.
Methods: Thirty-four patients with multiple myeloma admitted to Affiliated Hospital of Hebei University from November 2013 to December 2014 were included as research subjects. All patients received hematopoietic stem cell transplantation and were followed up for five years. Outcomes were evaluated according to the recovery status: complete response (CR), very good partial response (VGPR), partial response (PR), stable disease (SD), and progression disease (PD). In addition, the overall response rate (CR+VGPR) of patients was observed and their urine immunoglobulin status was measured by immunofixation electrophoresis. The Kaplan-Meier method was utilized to plot the survival curve, and the Log-rank method was adopted to analyze the relationship between CR+VGPR and PR and hematopoietic stem cell transplantation (HSCT) survival in patients with myeloma.
Results: The basic clinical type of immunofixation electrophoresis was as follows: 19 cases (55.88%) of IgG, 7 cases (20.59%) of IgA, 6 cases (17.65%) of IgM, and 2 cases (5.88%) of light chain type. Outcomes: 13 cases (38.24%) of CR, 12 cases (35.29%) of VGPR, 9 cases (26.47%) of PR, and 25 cases (73.53%) of the overall response rate (CR+VGPR). Compared with IgG, CR, VGPR and PR of IgA, IgM and light chain had statistically significant differences in outcome (p<0.05), and CR+VGPR of patients with IgG was higher than that of patients with IgA, IgM and light chain type (p<0.05). Two of the 34 patients were lost to follow-up. The log-rank analysis showed that the survival rate of patients with CR+VGPR was higher than that of patients with PR (p<0.05). Patients with IgA, IgM, and light chain type had an increased number of prognostic death compared with those with IgG (p<0.05).
Conclusion: Patients with IgG type myeloma are superior to those with IgA, IgM and light chain type in terms of the prognosis of hematopoietic stem cell transplantation, which has a certain clinical reference value.
doi: https://doi.org/10.12669/pjms.38.1.4425
How to cite this:Zhu S, Yang C, Li W, Lin M. Application of urine immunofixation electrophoresis in prognostic evaluation of hematopoietic stem cell transplantation in patients with myeloma. Pak J Med Sci. 2022;38(1):315-319. doi: https://doi.org/10.12669/pjms.38.1.4425
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Still Birth classification: Application of Relevant Condition at Death (ReCoDe) classification system in a tertiary care hospital of Pakistan
Authors: Kashif Urooj , Bhamani Shelina , Patel Asma , Islam Zaheena Shamsul 
Published: December 2021

Objectives: To determine the cause of stillbirth after application of relevant condition at death (ReCoDe) classification system.
Methods: This was a retrospective cross sectional study of 207 women diagnosed with stillbirth after 24 completed weeks of pregnancy at the Aga Khan University Hospital (AKUH), Karachi between 1st January 2015 and 31st December 2019. The primary objective was to find the cause of stillbirth according to the new classification of relevant condition at death (ReCoDe).
Results: There were a total of 32413 live births and 207 stillbirths during the study period thus stillbirth rate of 6 per 1000 live births. In this study, 80% of women were in the age group of 20-35 years, 16% had advanced maternal age while 3.8% of women accounted for less than 20 years. Among the maternal factors; 54.5% cases were booked and the remaining were were un-booked cases. Pre-eclampsia was the most common associated maternal condition (14.9%). Fetal cause accounted for 34.7% of stillbirths and the fetal growth restriction (FGR) was the most common; 23.6%. After application of ReCoDe classification, in 81% of stillbirth cases associated condition were found and only 18.8% of cases were categorized unexplained.
Conclusion: Application of ReCoDe classification is easy to understand and applicable, especially in low resource settings with associated causes identified in vast majority of cases.
doi: https://doi.org/10.12669/pjms.38.1.4470
How to cite this:Kashif U, Bhamani S, Patel A, Shamsul Islam Z. Still Birth classification: Application of Relevant Condition at Death (ReCoDe) classification system in a tertiary care hospital of Pakistan. Pak J Med Sci. 2022;38(1):133-137. doi: https://doi.org/10.12669/pjms.38.1.4470
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The causal model of health literacy and health behavior for obesity prevention among primary school students in Bangkok, Thailand
Authors: Thongsong Ladaporn , Neranon Wanida 
Published: December 2021

Background: The aim of the study was to develop a research instrument to study the levels of health literacy for obesity prevention (HLFOP), as well as health behavior for obesity prevention (HBFOP). In addition, we investigated the causal model between health literacy and health behavior for obesity prevention among primary school students in Bangkok, Thailand. Methods: A cross-sectional study among 600 participants who were primary school students (aged 9-13 years) was conducted. The participants were selected from schools in all parts of Bangkok using multi-stage random sampling technique. The research instrument to assess HLFOP and HBFOP, constructed by the researchers, were utilized for data collection. Data were analyzed using descriptive statistics, exploratory and confirmatory factor analyses, and structural equation model through linear structural relationship. Results: We found that HBFOP was directly influenced by heath literacy in the category of Critical Literacy with an effect size of 0.65 (p < 0.01), and was indirectly influenced in the category of Basic Literacy and Interactive Literacy through Critical Literacy with effect sizes of 0.46 and 0.58 (p<0.01), respectively. The model was consistent with the empirical data, with Chi-Square=13.68, df=7, p=0.05721, RMSEA (root mean square error of approximation)= 0.040, SRMR (standardized root mean square residual)= 0.017 NFI (normal fit index)=0.99, GFI (goodness of fit index)=0.99, and AGFI (adjusted goodness of fit index)=0.97. Conclusions: HLFOP was influential on HBFOP in primary school students in the Bangkok Metropolis. The categories that were particularly influential were: 1) Basic Literacy: accessing health information skills; 2) Interactive Literacy: communication skills; and 3) Critical Literacy: media literacy and self-management skills.
The knowledge, attitude, and practice towards coronavirus disease (COVID-19) among scuba divers in Saudi Arabia: A cross-sectional study
Authors: Al-Khalifa Khalifa S. , Alshuyukh Muneer H. , Alfaraj Amal , Shetty Ashwin C. , Alsahafi Yaser A. , Al-Swuailem Abdullah S. 
Published: December 2021

Background: The aim of this study was to investigate the knowledge, attitude, and practice (KAP) among scuba divers in Saudi Arabia towards equipment infection control measures, protective guidelines measures and potential post COVID-19 infection complications. Methods: A cross-sectional study using a pre-validated questionnaire was conducted. The questionnaire consisted of 35 close-ended questions, which covered the scuba divers’ profile and experience, the KAP of COVID-19 precautionary measures during diving activities as well as the demographic data and background of the scuba divers. KAP scores were subjected to non-parametric tests of statistical significance (Mann Whitney and Kruskal Wallis test). Statistical significance was set at p < 0.05. Results: Most of the 461 participants’ answers were in agreeance on the proper KAP of infection control during the COVID-19 pandemic. There was a statistically significant difference in attitude between all the demographic and professional variables (p<0.05) except for gender and region of residence (p>0.05). In addition, there was a statistically significant practice difference among age groups, education levels, and employee status in the diving center (p<0.05). Conclusions: Our findings showed that scuba divers presented a good level of KAP of infection control measures against the spread of the coronavirus disease. Local officials and diving organizations need to continue their efforts in combating and control the spread of this pandemic.
Non-combustion non-solar deployment characterization of a free-piston Stirling engine to integrate with an exothermic reactor
Authors: Eusha Muhammad , Schulz Wolfgang , Schumacher Günter , Mir Faraz Rasheed , Schories Gerhard 
Published: December 2021

Background: A small 1 kW free-piston β type Stirling engine was tested for its feasibility of integration with an exothermic reactor under the EU funded research project SOCRATCES (GA 727348). The engine’s heat receptor was minimally modified to adapt it to the reactor’s integration needs, introducing, instead of a combustion chamber, a CFD-optimized hooded enclosure. The open-loop configuration also included a small plate heat exchanger acting as a recuperator. The study attempted to investigate the performance of the Stirling engine under these non-combustion non-solar deployment conditions, focusing on conversion efficiency and thermal loss. Methods: A number of tests were run under different temperatures and flowrates to assess the engine’s response. Temperature, power, pressure and flowrate were measured at points of interest. Results: It was found that the engine is able to operate at efficiencies comparable to that of gasoline engines at much lower working fluid temperatures. It was possible to demonstrate, with the aid of a downstream recuperator, that the system in an open-loop configuration can minimize thermal loss significantly, virtually eliminating it in some cases. Conclusions: The Stirling engine appears to be a sound choice, in terms of conversion efficiency, at comparatively low temperatures, to be integrated with an exothermic reactor, at least at small-scale applications.
Household serial interval of COVID-19 and the effect of Variant B.1.1.7: analyses from prospective community cohort study (Virus Watch)
Authors: Geismar Cyril , Fragaszy Ellen , Nguyen Vincent , Fong Wing Lam Erica , Shrotri Madhumita , Beale Sarah , Rodger Alison , Lampos Vasileios , Byrne Thomas , Kovar Jana , Navaratnam Annalan M D , Patel Parth , Aldridge Robert W , Hayward Andrew ,   on behalf of Virus Watch Collaborative
Published: December 2021

Introduction: Increased transmissibility of B.1.1.7 variant of concern (VOC) in the UK may explain its rapid emergence and global spread. We analysed data from putative household infector - infectee pairs in the Virus Watch Community cohort study to assess the serial interval of COVID-19 and whether this was affected by emergence of the B.1.1.7 variant. Methods: The Virus Watch study is an online, prospective, community cohort study following up entire households in England and Wales during the COVID-19 pandemic. Putative household infector-infectee pairs were identified where more than one person in the household had a positive swab matched to an illness episode. Data on whether or not individual infections were caused by the B.1.1.7 variant were not available. We therefore developed a classification system based on the percentage of cases estimated to be due to B.1.1.7 in national surveillance data for different English regions and study weeks. Results: Out of 24,887 illnesses reported, 915 tested positive for SARS-CoV-2 and 186 likely ‘infector-infectee’ pairs in 186 households amongst 372 individuals were identified. The mean COVID-19 serial interval was 3.18 (95%CI: 2.55-3.81, sd=4.36) days. There was no significant difference (p=0.267) between the mean serial interval for VOC hotspots (mean = 3.64 days, (95%CI: 2.55 – 4.73)) days and non-VOC hotspots, (mean = 2.72 days, (95%CI: 1.48 – 3.96)). Conclusions: Our estimates of the average serial interval of COVID-19 are broadly similar to estimates from previous studies and we find no evidence that B.1.1.7 is associated with a change in serial intervals. Alternative explanations such as increased viral load, longer period of viral shedding or improved receptor binding may instead explain the increased transmissibility and rapid spread and should undergo further investigation.
Missed nursing care in acute care hospital settings in low-middle income countries: a systematic review protocol
Authors: Imam Abdulazeez , Obiesie Sopuruchukwu , Aluvaala Jalemba , Maina Michuki , Gathara David , English Mike 
Published: December 2021

Background: Missed nursing care (care left undone or task incompletion) is viewed as an important early predictor of adverse patient care outcomes and is a useful indicator to determine the quality of patient care. Available systematic reviews on missed nursing care are based mainly on primary studies from developed countries, and there is limited evidence on missed nursing care from low-middle income countries (LMICs). We propose conducting a systematic review to identify the magnitude of missed nursing care and document factors and reasons associated with this phenomenon in LMIC settings.Methods and analysis: This protocol was developed using the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols (PRISMA-P). We will conduct literature searching across the Ovid Medline, Embase and EBSCO Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases, from inception to 2021. Two independent reviewers will conduct searches and data abstraction, and discordance will be handled by discussion between both parties. The risk of bias of the individual studies will be determined using the Newcastle-Ottawa Scale (NOS).Ethics and dissemination: Ethical permission is not required for this review as we will make use of already published data. We aim to publish the findings of our review in peer-reviewed journalsPROSPERO registration number:CRD42021286897 (27thOctober 2021)
The relationship between eating patterns, body image and emotional dysregulation: similarities between an excessive and normal body weight sample
Authors: Brytek-Matera Anna , Czepczor-Bernat Kamila , Modrzejewska Adriana 
Published: December 2021

Cel pracyZałożono, że poziom wysokiego niezadowolenia z ciała można przewidzieć na podstawie poziomu stylu jedzenia, świadomego jedzenia i rozregulowania emocjonalnego u osób z nadmierną i prawidłową masą ciała. Ponadto założono, że przy braku bezpośredniego związku między niezadowoleniem z ciała a innymi wyżej wymienionymi zmiennymi, świadome jedzenie będzie ważnym moderatorem tych relacji wśród pacjentów z nadmierną masą ciała, a także u osób z prawidłową masą ciała.MetodaDwieście dziewięćdziesiąt osiem uczestników wypełniło ankietę online. W badaniu wykorzystano cztery kwestionariusze: Body Attitude Test, Three Factor Eating Questionnaire, Difficulties in Emotion Regulation Scale oraz Mindful Eating Scale.WynikiW obu grupach (nadmierna masa ciała versus prawidłowa masa ciała) przewidywano wysoki poziom niezadowolenia z ciała w oparciu o wysoki poziom niekontrolowanego jedzenia i niski poziom świadomego jedzenia. Jednak wśród pacjentów z nadwagą i otyłością związek między zmiennymi był silniejszy i istniał dodatkowy znaczący predyktor w modelu regresji (jedzenie emocjonalne). Model ten wyjaśniał w większym stopniu wariancje niezadowolenia z ciała (nadmierna masa ciała: 59% w porównaniu do prawidłowej masy ciała: 49%). Ponadto, uważne jedzenie miało ogromne znaczenie u pacjentów z nadmierną masą ciała. Dowodem na to był znaczący efekt moderujący świadomego jedzenia w związku między niezadowoleniem z ciała a restrykcyjnym jedzeniem, a także rozregulowaniem emocjonalnym, ale tylko w przypadku osób z nadwagą i otyłością.WnioskiW celu zwiększenia skuteczności leczenia zaburzeń obrazu ciała, nieprawidłowych nawyków żywieniowych i rozregulowania emocjonalnego u pacjentów z nadwagą i otyłością w procesie terapeutycznym należy zwrócić większą uwagę na umiejętność świadomego jedzenia.
Tłumaczenie symultaniczne mowy noblowskiej w dydaktyce przekładu konferencyjnego
Authors: Biernacka Agnieszka 
Published: December 2021

Simultaneous Interpreting of a Nobel Lecture in Conference Interpreter Training
Simultaneous interpreting with text is a hybrid mode combining simultaneous with sight translation. As it constitutes an important element of the interpreter’s work, it must then be a component of conference interpreter training. Due to a scarce research in the field so far, the aim of this paper is to discuss an empirical longitudinal study of simultaneous interpreting of a Nobel lecture from Spanish into Polish. The results of the analysis show that during the preparation phase, it is not a selective analysis of such lexical items as proper names, numbers or unknown words, but rather a syntactic analysis, which enables to render compound statements in a specific register, as well as an in-depth cultural analysis, which contributes to acquiring knowledge across different fields necessary in conference interpreting.
Tłumacz ustny w postępowaniu karnym
Authors: Liber-Kwiecińska Katarzyna 
Published: December 2021

Interpreter in Criminal Proceeding
This article presents the role of an interpreter in criminal proceedings, Polish and international regulations governing the obligation to appoint an interpreter for criminal procedural activities, the problems of interpreters’ cooperation with justice authorities, and the results of a survey on the experiences of sworn interpreters who provide interpreting services to the Police, the prosecutor’s office, and the courts in criminal proceedings in the following aspects: ensuring safety in the course of the activities, expectations of foreigners and authorities’ representatives towards the interpreter, preparing the interpreter’s work station and ensuring appropriate working conditions, as well as agreeing upon an appropriate remuneration for interpreters. A total of fifty-five sworn interpreters who regularly provide interpreting services to justice authorities took part in the survey. Their task was to complete a questionnaire consisting of fourteen questions, half of which were closed single-choice questions and the rest were open-ended questions.