bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computed Tomographic Sarcopenia in Pancreatic Cancer: Further Utilization to Plan Patient Management
Authors: Jalal Mustafa , Campbell Jennifer A. , Wadsley Jonathan , Hopper Andrew D. 
Published: July 2021

Abstract
Purpose
The presence of a sarcopenia adversely affects the prognosis of patients with pancreatic cancer. There is an emerging role for using computed tomography (CT) to calculate skeletal muscle index (SMI) and the presence of sarcopenia. The aim of this study was to assess if detecting ‘computed tomographic sarcopenia’ is feasible and can contribute to the management of patients with locally advanced pancreatic cancer (LAPC).

Methods
Patients diagnosed with LAPC referred for endoscopic ultrasound-guided biopsy (EUS-B) by our regional cancer network were identified. Age, body mass index (BMI), and Eastern Cooperative Oncology Group performance status (ECOG-PS) were noted. CT images were analysed for SMI and the presence of sarcopenia. Decision outcomes on receiving chemotherapy or not were collected from the regional oncology database.

Results
In total, 51/204 (25%) patients with LAPC who underwent EUS-B were not given chemotherapy and received best supportive care (BSC) only. The prevalence of sarcopenia (p = 0.0003), age ≥ 75 years old (p = 0.03), and ECOG-PS 2–3 (p = 0.01) were significantly higher in the patients receiving BSC only. Logistic regression analysis demonstrated that SMI was the only independent associated factor identifying patients with LAPC who were treated with BSC only and not chemotherapy after adjusting for age and ECOG-PS.

Conclusion
Our study has shown that computed tomographic skeletal muscle analysis at the time of a diagnostic CT for patients with pancreatic cancer is feasible and can detect sarcopenia and malnourished patients who are much less likely to take up chemotherapy. These patients could be triaged to oncology assessment prior to EUS-B to avoid unnecessary investigations.
Jacquemontia (Convolvulaceae) in Bolivia and Peru
Authors: Wood John R. I. , Clegg Rosemary 
Published: July 2021

SummaryA taxonomic account ofJacquemontiaChoisy in Bolivia and Peru is presented. All recognised species from the two countries are described and their distribution, ecology and conservation status are outlined. Separate keys to the species occurring in each country are also provided. All species are mapped and illustrated with line drawings and/or photographs. Five new species,Jacquemontia bolivianaJ.R.I.Wood,J. chuquisacensisJ.R.I.Wood,J. cuspidataJ.R.I.Wood,J. longipedunculataJ.R.I.Wood andJ. mairaeJ.R.I.Wood & R.Clegg are described from the Andes of Bolivia. Taxonomic notes are provided for many species,J. heteranthaNees & Mart. is treated as a synonym ofJ. cumanensis(Kunth) Kuntze andJ. prominensHelwig ofJ. unilateralis(Roem. & Schult.) O’Donell. Lectotypes are chosen forConvolvulus agrestisMart. ex Choisy,C. mucronatusBenth.,Ipomoea selloivar.rufescens(Meisn.) Hallier f.,Jacquemontia acuminataRusby,J. azureavar.albaSeeman,J. corymbulosaBenth.,J. densifloraRusby,J. guayaquilensisMeisn.,J. pedunculataRusby,J. sphaerocephalaMeisn. andJ. violaceavar.densifloraMeisn.
Linking Wine Culture and Geoheritage—Missing Opportunities at European UNESCO World Heritage Sites and in UNESCO Global Geoparks? A Survey of Web-Based Resources
Authors: Pijet-Migoń Edyta , Migoń Piotr 
Published: July 2021

AbstractVine cultivation is strongly dependent on local terrain conditions, including geology, landforms and soils. This offers an opportunity to develop interpretation and geo-education that would holistically relate wine culture to abiotic environment. Wine-related cultural landscapes inscribed on the UNESCO World Heritage List and those UNESCO Global Geoparks, where wine production is an important economic activity or leaves a distinctive imprint on the landscape, are particularly suited to emphasize local geoheritage in this specific context. We analyzed official web-based resources of UNESCO World Heritage Committee, UNESCO Global Geoparks programme, individual World Heritage properties and individual global geoparks to evaluate whether causal relationships between geoheritage, geodiversity and wine culture are indicated at all, and if so, how they are presented and linked to geotourism and geo-education. Our analysis involved 14 World Heritage properties and 38 global geoparks, all located in Europe. General observation is that given web-based information alone, the theme is insufficiently explored and poorly communicated to the public, although more recent nomination dossiers for World Heritage contain extensive presentations of abiotic environment. These are, however, not very likely to be consulted by the general public. In global geoparks, wine culture is mainly presented as a sustainable local activity, with local wine as one of brand products, whereas geoheritage context is seldom considered in depth. Growing interest in wine tourism and increasing appreciation of the value of cultural landscapes provide a good background to develop geo-interpretation and thereby to raise awareness of geoheritage matters.
Broken promises: a rights-based analysis of marginalised livelihoods and experiences of food insecurity in large-scale land investments in Tanzania
Authors: Talleh Nkobou Atenchong , Ainslie Andrew , Lemke Stefanie 
Published: July 2021

AbstractProponents of large-scale land investments (LSLI) still promote them as a development opportunity, which can lead, among other benefits, to job creation and enhanced food security for local communities. However, there is increasing evidence that these investments often deprive affected communities of their access to land, with multiple negative impacts on livelihoods, food security and on the environment. This paper relies on empirical data to present an analysis of LSLI and food (in)security – crucially at the level of individuals in two villages in the Ruvuma region, Tanzania, over 10 years after the acquisition of village land within the Southern African Growth Corridor of Tanzania (SAGCOT). We introduce an innovative framework that permits an integration of a rights-based approach with the Sustainable Livelihoods Framework to explore smallholders’ livelihoods and experiences of food insecurity. Our paper demonstrates how this integration, along with attention we have given to the FAO’s PANTHER principles, adds the missing yet crucial dimension of accountability on the part of national governments as duty bearers. Our findings show that in the case of these two villages, the human rights principles of participation, accountability, transparency and empowerment are severely undermined, with women bearing the brunt in all these domains. This overall state of affairs is, we argue, due to inadequate monitoring and evaluation of LSLI processes themselves and low levels of commitment on the part of institutions in Tanzania to monitor the promises made by investors. This in turn demonstrates an accountability deficit on the part of duty-bearers within LSLIs, and limited capacity of affected community members to claim their rights. Individual food insecurity experience in the two communities correlates, among other characteristics, with lack of land ownership, employment and income-generating activities. The rights-based livelihoods framework applied in this study points to serious deficiencies in the LSLI model as presently endorsed in SAGCOT, and emphasises the fact that access to land in Tanzania is a precondition for the realisation of the right to adequate food and thus a critical requirement for achieving and maintaining food and nutrition security. We conclude by arguing that progressive coalitions within and beyond national states must devise policies and institutions that empower individuals and civil society actors to make demands on their governments to respect, protect and fulfil their obligations regarding the legally enforceable right to food.
Epistemological Equation for Analysing Uncontrollable States in Complex Systems: Quantifying Cyber Risks from the Internet of Things
Authors: Radanliev Petar , De Roure David , Burnap Pete , Santos Omar 
Published: July 2021

AbstractThe Internet-of-Things (IoT) triggers data protection questions and new types of cyber risks. Cyber risk regulations for the IoT, however, are still in their infancy. This is concerning, because companies integrating IoT devices and services need to perform a self-assessment of its IoT cyber security posture. At present, there are no self-assessment methods for quantifying IoT cyber risk posture. It is considered that IoT represent a complex system with too many uncontrollable risk states for quantitative risk assessment. To enable quantitative risk assessment of uncontrollable risk states in complex and coupled IoT systems, a new epistemological equation is designed and tested though comparative and empirical analysis. The comparative analysis is conducted on national digital strategies, followed by an empirical analysis of cyber risk assessment approaches. The results from the analysis present the current and a target state for IoT systems, followed by a transformation roadmap, describing how IoT systems can achieve the target state with a new epistemological analysis model. The new epistemological analysis approach enables the assessment of uncontrollable risk states in complex IoT systems—which begin to resemble artificial intelligence—and can be used for a quantitative self-assessment of IoT cyber risk posture.
Ligands of the Neuropeptide Y Y2 Receptors as a Potential Multitarget Therapeutic Approach for the Protection of the Neurovascular Unit Against Acute Ischemia/Reperfusion: View from the Perspective of the Laboratory Bench
Authors: Przykaza Łukasz , Kozniewska Ewa 
Published: July 2021

AbstractIschemic stroke is the third leading cause of death and disability worldwide, with no available satisfactory prevention or treatment approach. The current treatment is limited to the use of “reperfusion methods,” i.e., an intravenous or intra-arterial infusion of a fibrinolytic agent, mechanical removal of the clot by thrombectomy, or a combination of both methods. It should be stressed, however, that only approximately 5% of all acute strokes are eligible for fibrinolytic treatment and fewer than 10% for thrombectomy. Despite the tremendous progress in understanding of the pathomechanisms of cerebral ischemia, the promising results of basic research on neuroprotection are not currently transferable to human stroke. A possible explanation for this failure is that experiments on in vivo animal models involve healthy young animals, and the experimental protocols seldom consider the importance of protecting the whole neurovascular unit (NVU), which ensures intracranial homeostasis and is seriously damaged by ischemia/reperfusion. One of the endogenous protective systems activated during ischemia and in neurodegenerative diseases is represented by neuropeptide Y (NPY). It has been demonstrated that activation of NPY Y2 receptors (Y2R) by a specific ligand decreases the volume of the postischemic infarction and improves performance in functional tests of rats with arterial hypertension subjected to middle cerebral artery occlusion/reperfusion. This functional improvement suggests the protection of the NVU. In this review, we focus on NPY and discuss the potential, multidirectional protective effects of Y2R agonists against acute focal ischemia/reperfusion injury, with special reference to the NVU.
Diagnostic assessment of reservoir response to fracturing: a case study from Hydraulic Fracturing Test Site (HFTS) in Midland Basin
Authors: Maity Debotyam , Ciezobka Jordan 
Published: July 2021

AbstractThis paper outlines a data collection and diagnostics case study involving multiple horizontal shale wells. We look at well production profiles using rate transient analysis, differences in near wellbore complexity, geologic variations within the area of interest, as well as compositional differences in the rocks based on cores obtained from within the stimulated reservoir. The Hydraulic Fracturing Test Site is a multi-well experiment involving stimulation of unconventional shale wells in the southeastern Midland portion of the Permian Basin. The targeted formations include both the upper as well as the middle Wolfcamp formations, also referred alternatively as Wolfcamp A and Wolfcamp B. Data integration and analysis shared in this paper help us understand the various geologic controls impacting well productivity, particularly the wide variance observed between the Wolfcamp A and Wolfcamp B formations. Rate transient analysis indicates similar system permeabilities for stimulated wells. However, we observe higher effective fracture half-lengths for upper Wolfcamp wells. Using observations from 3D seismic interpretations (such as pad scale faults) as well as petrophysical and image log data, we highlight the substantial differences in stimulation as we move along the well laterals from the heel toward the toe sections. These differences are further reconciled with observations from zones with high data density at the core locations through stimulated rock, as well as independent data such as microseismic emissions. At the test site, Wolfcamp A was found to be relatively quartz rich with significant heterogeneity whereas Wolfcamp B is richer in clay and organic content. This impacts the geomechanical characteristics of the rock mass with much higher natural fracture density in the shallower interval. Thus, the fracture growth is more uniform in the deeper interval and more heterogeneous with branching likely in upper interval. Increased complexity also leads to consistently better productivity from the wells in the shallower interval as demonstrated from RTA results. This case study is unique because it provides valuable insights from actual sampling of the stimulated zones in hydraulically fractured wells and helps understand impact of various factors that contribute toward variability in well production. The findings from this study provides insights into need for optimization of completion designs in the various Wolfcamp landing zones, such as optimization of cluster or fracture spacing in various Wolfcamp intervals. In addition, it provides a useful template for data collection and research direction in future field test sites of similar nature in unconventional reservoirs.
Hemicellulosic biomass conversion by Moroccan hot spring Bacillus paralicheniformis CCMM B940 evidenced by glycoside hydrolase activities and whole genome sequencing
Authors: Maski Soufiane , Ngom Serigne Inssa , Rached Bahia , Chouati Taha , Benabdelkhalek Mohamed , El Fahime Elmostafa , Amar Mohamed , Béra-Maillet Christel 
Published: July 2021

AbstractThermophilic bacteria, especially from the genus Bacillus, constitute a huge potential source of novel enzymes that could be relevant for biotechnological applications. In this work, we described the cellulose and hemicellulose-related enzymatic activities of the hot spring Bacillus aerius CCMM B940 from the Moroccan Coordinated Collections of Microorganisms (CCMM), and revealed its potential for hemicellulosic biomass utilization. Indeed, B940 was able to degrade complex polysaccharides such as xylan and lichenan and exhibited activity towards carboxymethylcellulose. The strain was also able to grow on agriculture waste such as orange and apple peels as the sole carbon source. Whole-genome sequencing allowed the reclassification of CCMM B940 previously known as B. aerius into Bacillus paralicheniformis since the former species name has been rejected. The draft genome reported here is composed of 38 contigs resulting in a genome of 4,315,004 bp and an average G + C content of 45.87%, and is an important resource for illuminating the molecular mechanisms of carbohydrate metabolism. The annotated genomic sequences evidenced more than 52 genes encoding glycoside hydrolases and pectate lyases belonging to 27 different families of CAZymes that are involved in the degradation of plant cell wall carbohydrates. Genomic predictions in addition to in vitro experiments have revealed broad hydrolytic capabilities of the strain, thus reinforcing its relevance for biotechnology applications.
The experience of intolerance of uncertainty for parents of young people with a restrictive eating disorder
Authors: Konstantellou Anna , Sternheim Lot , Hale Lucy , Simic Mima , Eisler Ivan 
Published: July 2021

Abstract
Purpose
This study aimed to explore how parents of young people with a restrictive eating disorder (ED) experience and manage uncertainty.

Methods
Seventeen parents of young people with a restrictive ED were recruited from multi-family therapy groups run within a specialised ED clinic. Five focus groups were conducted asking parents about their experience of uncertainty both prior and after the onset of their child’s illness.

Results
Data were analysed using interpretative phenomenological analysis which yielded seven superordinate themes. (1) Anorexia nervosa and uncertainty, (2) Positive and negative experiences of uncertainty (3), Helpful and unhelpful ways of coping with uncertainty, (4) Parent’s self-efficacy and uncertainty (5), Needs of parents, (6) Parents’ perceptions of intolerance of uncertainty in their children and (7) Impact of uncertainty on family life.

Conclusion
Parents caring for young people with a restrictive ED exhibit a strong intolerance of uncertainty, particularly in relation to their child’s illness. This ‘negative uncertainty’ was thought to reduce their confidence as parents in how they managed their child’s ED. Targeting high levels of intolerance of uncertainty in parents caring for young people with an ED could be beneficial for supporting parents when faced with their child’s illness, increasing parental self-efficacy, decreasing accommodating behaviours and ultimately contributing to improved treatment outcomes.

Level of evidence
Level V: Opinions of authorities, based on descriptive studies, narrative reviews, clinical experience, or reports of expert committees.
Effects of solid friction modifier on friction and rolling contact fatigue damage of wheel-rail surfaces
Authors: Song Jingdong , Shi Lubing , Ding Haohao , Galas Radovan , Omasta Milan , Wang Wenjian , Guo Jun , Liu Qiyue , Hartl Martin 
Published: July 2021

AbstractIn railway network, friction is an important factor to consider in terms of the service behaviors of wheel-rail system. The objective of this study was to investigate the effect of a solid friction modifier (FM) in a railway environment. This was achieved by studying the friction, wear, and rolling contact fatigue (RCF) damage on the wheel-rail materials at different slip ratios. The results showed that when a solid FM was applied, the friction coefficient decreased. After the solid FM was separated from the wheel-rail interface, the friction coefficient gradually increased to its original level. With the application of the solid FM, the wear rates of the wheel-rail decreased. In addition, the thickness and hardness of the plastic deformation layers of the wheel-rail materials were reduced. The worn surfaces of the wheel-rail were dominated by pits and RCF cracks. Without the FM, RCF cracks ranged from 84 to 120 µm, and subsurface cracks were generated. However, with the FM, RCF cracks ranged from 17 to 97 µm and no subsurface cracks were generated. These findings indicate possible methods of improving the performance of railway rolling stock by managing friction, and reducing wear and permanent RCF damage affecting both the wheels and rails.
A neutral core of degressively proportional allocations under lexicographic preferences of agents
Authors: Cegiełka Katarzyna , Dniestrzański Piotr , Łyko Janusz , Maciuk Arkadiusz , Szczeciński Maciej 
Published: July 2021

AbstractOne of the main problems of practical applications of degressively proportional allocations of goods and burdens is lack of uniqueness of this principle. Even under given boundary conditions of allocation, i.e. determined minimal and maximal amounts of a good that can be assigned in a given allocation, there are usually many feasible solutions. The lack of formal rules of allocation is the reason why the allocation is typically a result of negotiations among its agents. A number of allocations favor some of agents or their groups, therefore other agents cannot accept them. The aim of this paper is to indicate a way of reducing the set of all feasible solutions exclusively to those that are neutral to all agents. As a result of the term of lexicographic preference of allocation agents defined on the basis of the relation theory followed by a numerical analysis of sets of all feasible solutions, it is possible to determine a core of this set in the form of a subset of all feasible solutions that are acceptable by all agents. In addition, this subset can be further divided into smaller subsets with regard to the degree of acceptance of their elements. Theoretical analysis is complemented by case studies, one of which is application of this idea to the allocation of seats in the European Parliament among the member states of the European Union.
Age, Gender, and Crime in a Stockholm Birth Cohort to Age 64
Authors: Carlsson Christoffer , Sivertsson Fredrik 
Published: July 2021

AbstractWe study the criminal histories of 14,608 males and females in a full Stockholm birth cohort born in 1953 to age 64. Using an update of The Stockholm Birth Cohort Study data, we explore the amount of crimes recorded in the cohort before and after the advent of adulthood. We break down the age/crime curve into separate parameters, including onset, duration, and termination. Throughout, we utilize the large number of females (49%; n = 7 161) in the cohort, and compare long-term patterns of male and female criminal careers. Next, we focus on adulthood, and explore the existence and parameters of the adult-onset offender and its contribution to the overall volume of crime in the cohort. While crime peaks in adolescence, the main bulk of crimes in the cohort occurred after the dawning of adulthood. Nearly half of all male, and more than two-thirds of all female, crimes in the cohort occurred after age 25. In the case of violence, the majority of offences — around two-thirds for both genders — took place in adulthood. Around 23% of all males and 38% of all females with a criminal record in the cohort were first recorded for a criminal offence in adulthood. While a majority were convicted only once, a proportion of adult-onset offenders had a considerable risk of recidivism and repeated recidivism. These results suggest that quite a substantial proportion of the population initiate crime in adulthood, and that these offenders account for a nonnegligible proportion of adult crime.
Unlikely SARS-CoV-2 Transmission During Vaginal Delivery
Authors: Fenizia Claudio , Saulle Irma , Di Giminiani Maria , Vanetti Claudia , Trabattoni Daria , Parisi Francesca , Biasin Mara , Savasi Valeria 
Published: July 2021

AbstractPregnant women display a higher risk of progression to disease and higher viral loads during infections due to their more permissive, tolerogenic immune system. However, only few studies have focused on SARS-CoV-2 intrapartum vertical transmission via vaginal secretions or faeces. The aim of this study was to investigate the presence of the virus in vaginal, rectal and blood specimens from pregnant women characterized by different COVID-19 disease severity. We enrolled 56 SARS-CoV-2-positive pregnant women, of which 46 (82%) were in the third trimester of pregnancy, 6 (10%) in the second and 4 (7%) in the first. QPCR was performed to detect the virus in vaginal and rectal swabs and in plasma samples. SARS-CoV-2 was detected in 27% of rectal swabs of pregnant women in the third trimester, while no virus particles were detected in vaginal swabs of the same patients. Furthermore, only 4% plasma samples tested positive to SARS-CoV-2. No virus was detected in newborn’s nasopharyngeal swabs. Despite the low number of subjects enrolled, our data suggest that, while theoretically possible, intrapartum vaginal or orofecal SARS-CoV-2 transmission seems to be unlikely.