bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN SANITASI LINGKUNGAN DENGAN KEJADIAN DIARE PADA BALITA DI RAWAT INAP RSUD PRINGSEWU LAMPUNG
Authors: . Yusnita 
Published: November 2021

Hubungan Sanitasi Lingkungan Dengan Kejadian Diare Pada Balita Di Rawat Inap Rsud Pringsewu Lampung. Diare merupakan suatu penyakit system pencernaan yang dapat menggagu aktifitas, diare harus segera di atasi karena dapat mengakibatkan kehilangan cairan dan kematian terutama pada balita. Faktor yang dapat menyebabkan diare diantaranya sanitasi lingkungan yang kurang baik seperti pembuangan kotor anmanusia yang tidak sesuai dengan standar kesehatan dan penyediaan air bersih yang digunakan untuk keperluan sehari-hari. Tujuan dalam penelitian ini untuk mengetahui hubungan sanitasi lingkungan dengan kejadian diare pada pasien balita di ruang rawat inap anak RSUD Pringsewu tahun 2020. Penelitian ini menggunakan metode survey analitik dengan pendekatan cross sectional dan sampel yang digunakan adalah ibu-ibu yang memiliki balita dengan diare sebanyak 40 orang. Hasil penelitian ini menunjukan bahwa ada hubungan antara penggunaan sumber air bersih dengan kejadian diare pada pasien balita yang di rawat di ruang rawat inap RSUD Pringsewu tahun2020, ditunjukan dengan hasil uji chi-square didapatkan nilaip-value 0,021 dengan nilai OR 6,125. Ada hubunga nantara pembuangan kotoran manusia dengan kejadian diare, ditunjukkan dengan nilaip-value 0,008 dengan nilai OR 8,75. Diharapkan bagi petugas RSUD Pringsewu untuk dapat memberikan pendidikan kesehatan tentang penyebab diare, sehingga dapat menurunkan angka kejadian diare pada balita.
E-2 Development of Islamic Counseling Protocol for Pakistani Muslim Adults to Manage their Mental Health Problems
Authors: Khan Aqeel Ahmad , Nadeem Masood 
Published: November 2021

Religion plays a fundamental role in our life. Therefore, a religious approach is known as a pivotal to be incorporated in counseling session with the clients. Researchers and religious scholars emphases that there is a crucial need to integrate the religious aspects during counseling process. This qualitative study was carried out to develop the Islamic Counseling Protocol (Counselor/Client Worksheet) for Pakistani Muslims adults in the light of Holy Quran, Al-Sunnah and the relevant literature available in the realm of Islamic Counseling. In this connection, firstly all the methods used in Islamic counseling available in literature review were identified. Secondly, the Quranic Versus were identified in relation to the treatment of mental health problems (stress, anxiety and depression). On the basis of selected versus and methods from the Holy Quran as well as from Al-Sunnah, the Islamic Counseling protocol (counselor client worksheet) was developed for Pakistani Muslim adults to manage their mental health problems (stress, anxiety and depression). The results of this qualitative research proposed 6-sessions of Islamic Counseling to manage the mental health problems of the individuals with stress, anxiety and depression.
UM CURIOSO CASO DE NASALIDADE EM UMA VARIANTE DIALETAL DO PORTUGUÊS BRASILEIRO: UMA ANÁLISE ACÚSTICA
Authors: Malta Cinthia 
Published: November 2021

Este trabalho apresenta uma análise acústica acerca do fenômeno da nasalidade no português brasileiro, dialeto de Vitória da Conquista, região sudoeste da Bahia. Os parâmetros acústicos considerados foram os três primeiros formantes orais (F1, F2 e F3). O presente estudo também faz uma revisão geral dos trabalhos em fonética e fonologia que fazem referência ao fenômeno. Os corpora investigados acusticamente compõem um grupo de palavras faladas por falantes nativos desse dialeto baiano. Os resultados mostraram que um outro tipo de nasalidade, que difere daquelas tão amplamente discutidas (nasalidade fonética e fonológica) ocorre nesse dialeto. Essa nasalidade dialetal ocorre num contexto em que não é previsto uma vogal nasal ou nasalizada. Essa pesquisa pretende contribuir para um melhor entendimento do fenômeno da nasalização.

Como citar:
SANTOS, Cinthia Malta dos. Um curioso caso de nasalidade em uma variante dialetal do português brasileiro: uma análise acústica. Orientadora: Vera Pacheco. 2015. 124f. Dissertação (mestrado em Linguística) – Universidade Estadual do Sudoeste da Bahia, Programa de Pós-graduação em Linguística, Vitória da Conquista, 2015. DOI:https://doi.org/10.54221/rdtdppglinuesb.2015.v3i1.55. Acesso em: xxxxxxxx
Evaluation of Moisture Sensitivity Performance of Stone Mastic Asphalt Mixes with Additional Filler: A Laboratory Comparison of Dry and Wet Mixing Methods
Authors: CETIN Altan 
Published: November 2021

Gap-graded mixtures are one of the areas of improving the permanent deformation strength of hot-mixed asphalt mixtures. Additional filler materials can be needed due to the high bitumen amount and the less fine aggregate amount in the mixture. In this study, the effects of filler additives on moisture susceptibility of the gap-graded hot-mixed asphalt mixtures and mixing methods are investigated. Filler additives such as class C and class F fly ashes and hydrated lime are used 0.5 %, 1.0 %, 2.0 %, and 4 % of the total weight of mixture instead of mineral filler. Design mixtures are prepared according to the Turkish Highway Technical Specifications (THTS). To determine the effect of mixing methods, dry and wet (slurry) methods are used to mix the filler materials. Modified Lottman method (AASHTO T283) are used to determine the moisture susceptibility. An indirect tensile strength test is the measurement of bitumen film thickness which is also conducted. Test results showed that class C fly ash is significantly improved the moisture susceptibility of mixtures. While the slurry method does not give the expected improvement on class C fly ash added mixtures, it shows a positive effect on class F fly ash and hydrated lime added mixtures.
“Tape dermatoscopy”: constructing a low-cost dermatoscope using a mobile phone, immersion fluid and transparent adhesive tape
Authors: Blum Andreas , Giacomel Jason 
Published: November 2021

Importance: Medical professionals and indeed the general public have an increasing interest in the acquisition of dermatoscopic images of suspect or ambiguous skin lesions. To this end, good dermatoscopic image quality and low costs are important considerations.
Observations: Images of seven lesions (seborrheic keratosis, melanoma in-situ, blue and dermal nevus, basal cell carcinoma and two squamous cell carcinomas) were taken. A novel technique of “tape dermatoscopy” involved:

Using immersion fluid (i.e., water, olive oil, disinfectant spray) placed on the flat or slightly elevated lesion;
Covering the lesion with transparent adhesive tape with lateral tension;
Using ambient indoor or outdoor lighting for illumination (rather than flash photography);
Positioning a photographic device at an angle of approximately 45° from the side of the lesion to avoid light reflection;
Recording a focused image with a mobile phone or digital camera at a distance of approximately 25-30 cm from the lesion; and
Enlarging the image on the screen of the device.

Essential dermatoscopic features enabling a correct diagnosis were visible in 6 of the 7 lesions. “Tape dermatoscopy” images of the lesions were compared to standard dermatoscopy (using a Fotofinder handyscope® in combination with a mobile phone). The latter confirmed the dermatoscopic features in six of seven lesions.
Conclusions and Relevance: “Tape dermatoscopy” images can be recorded by medical personnel and even the general public without a dermatoscope. However, the limitations of this method are that images may be unfocused, exophytic tumors may be difficult to assess, excess pressure on tumoral blood vessels may lead to compression artefact, dermatoscopic features that are only visible under polarized light are unable to be detected (particularly “crystalline” or “chrysalis” structures) and tumors in certain anatomic locations may be difficult to assess (e.g., edges of nose, ears [demonstrated in one case], nails). Comparative prospective studies are necessary in order to test reproducibility of these preliminary findings, to establish special indications for the technique, and to develop guidelines for its effective use.
Changes in the urinary proteome in rats with regular swimming exercise
Authors: Meng Wenshu , Xu Dan , Meng Yunchen , Zhang Weinan , Xue Yaqi , Zhen Zhiping , Gao Youhe 
Published: November 2021

Purpose
Urine can sensitively reflect early pathophysiological changes in the body. The purpose of this study was to explore the changes of urine proteome in rats with regular swimming exercise.

Methods
In this study, experimental rats were subjected to daily moderate-intensity swimming exercise for 7 weeks. Urine samples were collected at weeks 2, 5, and 7 and were analyzed by using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).

Results
Unsupervised clustering analysis of all urinary proteins identified at week 2 showed that the swimming group was distinctively different from the control group. Compared to the control group, a total of 112, 61 and 44 differential proteins were identified in the swimming group at weeks 2, 5 and 7, respectively. Randomized grouping statistical analysis showed that more than 85% of the differential proteins identified in this study were caused by swimming exercise rather than random allocation. According to the Human Protein Atlas, the differential proteins that have human orthologs were strongly expressed in the liver, kidney and intestine. Functional annotation analysis revealed that these differential proteins were involved in glucose metabolism and immunity-related pathways.

Conclusion
Our results revealed that the urinary proteome could reflect significant changes after regular swimming exercise. These findings may provide an approach to monitor the effects of exercise of the body.
SAM‐dPCR: Accurate and Generalist Nuclei Acid Quantification Leveraging the Zero‐Shot Segment Anything Model
Authors: Wei Yuanyuan , Luo Shanhang , Xu Changran , Fu Yingqi , Zhang Yi , Qu Fuyang , Zhang Guoxun , Ho Yi‐Ping , Ho Ho‐Pui , Yuan Wu 
Published: December 2024

AbstractDigital PCR (dPCR) has transformed nucleic acid diagnostics by enabling the absolute quantification of rare mutations and target sequences. However, traditional dPCR detection methods, such as those involving flow cytometry and fluorescence imaging, may face challenges due to high costs, complexity, limited accuracy, and slow processing speeds. In this study, SAM‐dPCR is introduced, a training‐free open‐source bioanalysis paradigm that offers swift and precise absolute quantification of biological samples. SAM‐dPCR leverages the robustness of the zero‐shot Segment Anything Model (SAM) to achieve rapid processing times (<4 seconds) with an accuracy exceeding 97.10%. This method has been extensively validated across diverse samples and reactor morphologies, demonstrating its broad applicability. Utilizing standard laboratory fluorescence microscopes, SAM‐dPCR can measure nucleic acid template concentrations ranging from 0.154 copies µL−1 to 1.295 × 103 copies µL−1 for droplet dPCR and 0.160 × 103 to 3.629 × 103 copies µL−1 for microwell dPCR. Experimental validation shows a strong linear relationship (r2 > 0.96) between expected and determined sample concentrations. SAM‐dPCR offers high accuracy, accessibility, and the ability to address bioanalytical needs in resource‐limited settings, as it does not rely on hand‐crafted “ground truth” data.
Hepatocyte‐Derived FGF1 Alleviates Isoniazid and Rifampicin‐Induced Liver Injury by Regulating HNF4α‐Mediated Bile Acids Synthesis
Authors: Lin Qian , Zhang Jiaren , Qi Jie , Tong Jialin , Chen Shenghuan , Zhang Sudan , Liu Xingru , Lou Huatong , Lv Jiaxuan , Lin Ruoyu , Xie Junjun , Jin Yi , Wang Yang , Ying Lei , Wu Jiamin , Niu Jianlou 
Published: December 2024

AbstractIsoniazid and rifampicin co‐therapy are the main causes of anti‐tuberculosis drug‐induced liver injury (ATB‐DILI) and acute liver failure, seriously threatening human health. However, its pathophysiology is not fully elucidated. Growing evidences have shown that fibroblast growth factors (FGFs) play a critical role in diverse aspects of liver pathophysiology. The aim of this study is to investigate the role of FGFs in the pathogenesis of isoniazid (INH) and rifampicin (RIF)‐induced liver injury. Through systematic screening, this study finds that hepatic FGF1 expression is significantly downregulated in both mouse model and human patients challenged with INH and RIF. Hepatocyte‐specific Fgf1 deficiency exacerbates INH and RIF‐induced liver injury resulted from elevated bile acids (BAs) synthases and aberrant BAs accumulation. Conversely, pharmacological administration of the non‐mitogenic FGF1 analog – FGF1ΔHBS significantly alleviated INH and RIF‐induced liver injury via restoring BAs homeostasis. Mechanically, FGF1 repressed hepatocyte nuclear factor 4α (Hnf4α) transcription via activating FGF receptor 4 (FGFR4)‐ERK1/2 signaling pathway, thus reducing BAs synthase. The findings demonstrate hepatic FGF1 functions as a negative regulator of BAs biosynthesis to protect against INH and RIF‐induced liver injury via normalizing hepatic BAs homeostasis, providing novel mechanistic insights into the pathogenesis of ATB‐DILI and potential therapeutic strategies for treatment of ATB‐DILI.
Aneurysm Is Restricted by CD34+ Cell‐Formed Fibrous Collars Through the PDGFRb‐PI3K Axis
Authors: Wu Hong , Yang Xiaoping , Chen Ting , Yu Baoqi , Chen Mengjia , Wang Ting , Jiang Liujun , Zhang Bohuan , Zhou Xuhao , Cheng Junning , Chen Kai , Zhang Tao , Hu Yanhua , Xu Simon , Lian Jiangfang , Zhang Hongkun , Xiao Qingzhong , Ye Honghua , Xu Qingbo 
Published: December 2024

AbstractAortic aneurysm is a life‐threatening disease caused by progressive dilation of the aorta and weakened aortic walls. Its pathogenesis involves an imbalance between connective tissue repair and degradation. CD34+ cells comprise a heterogeneous population that exhibits stem cell and progenitor cell properties. However, the role of CD34+ cells in abdominal aortic aneurysm (AAA) remains unclear. In this study, downregulated CD34 expression is observed in aneurysmal aortas from both patients and mouse models compared to that in non‐dilated aortas. Furthermore, by combining Cd34‐CreERT2;Rosa26‐tdTomato;(Apoe−/−) lineage tracing, bone marrow transplantation, and single‐cell sequencing, it is found that during AAA development, non‐bone marrow CD34+ cells are activated to transdifferentiate into Periostin+ myofibroblasts, thereby contributing to the formation of fibrotic collars. Dual recombinase‐based lineage tracing confirms the presence and involvement of CD34+/Periostin+ myofibroblasts in fibrotic collar formation during AAA development. Functionally, selective depletion of systemic or non‐bone marrow CD34+ cells, as well as CD34+/Periostin+ myofibroblasts, by diphtheria toxin significantly exacerbates AAA progression and increases disease mortality. Mechanistically, it is identified that the PDGF‐PDGFRb‐PI3K axis is indispensable for Periostin+ myofibroblast generation from non‐bone marrow CD34+ cells in AAA, offering a new therapeutic target for patients with AAA at a high risk of rupture.
One‐Pot Synthesis of Oxygen Vacancy‐Rich Amorphous/Crystalline Heterophase CaWO4 Nanoparticles for Enhanced Radiodynamic‐Immunotherapy
Authors: Peng Shanshan , Chen Zhen , Wang Jun , Yu Meili , Niu Xuegang , Cui Tingting , Ao Rujiang , Cai Huilan , Huang Hongwei , Lin Lisen , Chen Xiaoyuan , Yang Huanghao 
Published: December 2024

AbstractRadiodynamic therapy that employs X‐rays to trigger localized reactive oxygen species (ROS) generation can tackle the tissue penetration issue of phototherapy. Although calcium tungstate (CaWO4) shows great potential as a radiodynamic agent benefiting from its strong X‐ray absorption and the ability to generate electron–hole (e−‐h+) pairs, slow charge carrier transfer and fast e−‐h+ recombination greatly limit its ROS‐generating performance. Herein, via a one‐pot wet‐chemical method, oxygen vacancy‐rich amorphous/crystalline heterophase CaWO4 nanoparticles (Ov‐a/c‐CaWO4 NPs) with enhanced radiodynamic effect are synthesized for radiodynamic‐immunotherapy of cancer. The phase composition and oxygen vacancy content of CaWO4 can be easily tuned by adjusting the solvothermal temperature. More intriguingly, the amorphous/crystalline interfaces and abundant oxygen vacancies accelerate charge carrier transfer and suppress e−‐h+ recombination, respectively, enabling synergistically improved ROS production from X‐ray‐irradiated Ov‐a/c‐CaWO4 NPs. In addition to directly inducing oxidative damage of cancer cells, radiodynamic generation of ROS also boosts immunogenic cell death to provoke a systemic antitumor immune response, thereby allowing the inhibition of both primary and distant tumors as well as cancer metastasis. This study establishes a synergistic enhancement strategy involving the integration of phase and defect engineering to improve the ROS generation capacity of radiodynamic‐immunotherapeutic anticancer nanoagents.
Integrating machine learning to uncover homogeneous catalytic mechanisms in N‐vinyl‐pyrrolidone synthesis
Authors: Zhang Zhiwei , Wang Fumin , Shen Qi , Zhang Xubin , Li Guobing , Zhu Bingxin , Shi Jinhua , Liu Shuai , Liu Qingzhao , Wang Zheng , Qin Yang , Zhao Qingshan 
Published: December 2024

AbstractCombining machine learning, density functional theory (DFT) calculation, and kinetic modeling offers significant advantages in studying reactions under complex conditions, enabling a detailed exploration of reaction mechanisms. Artificial neural network (ANN) models accurately predict and analyze the impact of reaction conditions, overcoming the limitations of traditional kinetic studies in complex systems. Specifically, the homogeneous catalytic reaction for synthesizing N‐vinylpyrrolidone from pyrrolidone and acetylene, which has stringent requirements, was selected. The ANN model effectively captured nonlinear relationships between residence time, moisture content, reaction temperature, catalyst concentration, reaction pressure, and catalyst preparation temperature. DFT calculations revealed the reaction pathways, leading to the development of a high‐precision predictive model. This approach not only uncovers potential reaction pathways and intermediates in complex reaction systems but also provides a new avenue for optimizing reaction conditions, resulting in more efficient catalyst design and process development in intricate reaction environments.
Dermal Exposure to Agrochemicals as Risk Factor for Skin Cancer in Farmers and Ranchers in the US Central States
Authors: Tucker Sarah , Du Yi , Ahmed Rishad , Haynatzki Gleb , Adhikari Suraj , Rautiainen Risto H. 
Published: December 2024

ABSTRACTBackgroundFarm operators are at a high risk of developing skin cancer due to their occupational sun exposure. With the growing incidence of skin cancer, it is also important to evaluate other occupational risk factors. Farm operators confront numerous physical, chemical, and biological hazards in their work environment. This study investigated whether dermal exposures to pesticides/fertilizers, animals/livestock, detergents/disinfectants, and fuels/solvents/paints were associated with the risk of skin cancer in farm and ranch operators.MethodsSurveillance data from the Central States Center for Agricultural Safety and Health (CS‐CASH) Farm and Ranch Health and Safety Surveys in 2018 and 2020 were used to explore the risk of skin cancer in farm operators in seven US central states. Farm production variables from the DTN Farm Market database were merged with survey responses. The associations of skin cancer and exposure variables were analyzed using descriptive statistics and regression modeling.ResultsThe prevalence of skin cancer was 10% among 7943 operators. Univariable analyses showed that men had 1.62 times higher odds of skin cancer compared to women. The odds of skin cancer increased significantly with age. Livestock, fed cattle, cow‐calf, and beef production increased the odds of skin cancer. Exposure to pesticides/fertilizers and fuels/solvents/paints also increased the odds of skin cancer compared to unexposed operators. In the final multivariable model, the associations of skin exposure to pesticides/fertilizers (odds ratio (OR) = 1.30, 95% CI: 1.08–1.56) and to fuels/solvents/paints (OR = 1.21, 95% CI: 1.01–1.45) remained statistically significant after adjusting for sex, age, and state. Having livestock also increased the odds of skin cancer (OR = 1.18, 95% CI: 1.00–1.38).ConclusionSkin is a critical source of occupational exposures among farm operators. Increased odds of skin cancer in this study emphasizes the need for better protection against exposures to chemicals including pesticides/fertilizers, and fuels/solvents/paints.
California Warehouse Industry Worker Injury Rates in the Occupational Health and Safety Administration's Injury Tracking Application, 2018–2023
Authors: Beckman Stella , Andamel Naissem , Harrison Robert 
Published: December 2024

ABSTRACTBackgroundOccupational health and safety surveillance in the US relies primarily on federal and state administrative data sources which all have limitations created by underreporting and different sampling frames. To begin closing data gaps, in 2019 the federal Occupational Health and Safety Administration began requiring many US business establishments to submit injury and illness data to the Injury Tracking Application (ITA). We present an example use of these data by characterizing injuries in the California warehousing industry.MethodsYearly ITA data for 2018–2023 were obtained and cleaned to exclude invalid records, resulting in 3717 records from California General Warehousing and Storage (GWS, NAICS 493110) establishments. Annual rates of total reportable injuries and cases of injuries requiring days of job transfer or restriction (DJTR) were calculated.ResultsTotal injury rates peaked in 2021, with 5.87 injuries per 100 workers. While total injury rates subsequently declined, 2023 DJTR rates remained elevated over 2018 rates (3.21 vs. 1.84 per 100 workers). The primary analytical limitations were potential bias due to underreporting, and difficulty in identifying warehouse establishments.ConclusionThe ITA data are a valuable addition to existing administrative data sources, with several limitations similar to those in other administrative datasets. The findings of consistently elevated total and DJTR injury rates in California's warehousing industry are consistent with previous research and indicate that outreach and enforcement efforts should be expanded to protect the health and safety of warehouse workers.