bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and genetic markers of prehypertension in North-Western Russian population
Authors: Erina A , Usoltsev U , Kolosov N , Solntsev V , Kostareva A , Palotie A , Daly M J , Konradi A , Rotar O , Artomov M 
Published: October 2021

Abstract

Introduction
Prehypertension is a medical classification for patients with above normal blood pressure (BP) but insufficient for confirming hypertension diagnosis. Condition is often asymptomatic as it gradually develops over the years, yet recent meta-analyses suggest that prehypertension is a significant risk factor for stroke and other cardiovascular diseases.

Methods
We analyzed phenotypic data from 879 (age 25–64) individuals without hypertension from a population based-sampling cohort of St. Petersburg region in the North-West of Russia to identify clinical risk factors associated with prehypertension condition. All patients were divided in two groups – optimal BP (systolic BP &lt;120 mmHg and diastolic BP &lt;80; N=426) and prehypertension (systolic BP in range 120–140 mmHg and diastolic BP in range 80–90 and not on antihypertensive therapy; N=453).

Results
Phenotypic analysis with linear regression was corrected for age, sex, smoking status, BMI and levels of LDL and HDL cholesterol (Figure 1). Interestingly, blood level of insulin was significantly associated with prehypertension status along with insulin resistance index, however, presence of diabetes diagnosis in medical history was not significant. Phenotypes associated with prehypertension suggest that prehypertension is often developing along with hyperinsulinemia.
Finally, we estimated polygenic risk scores (PRS) for hypertension using UK biobank GWAS summary statistics and confirmed that prehypertension is more frequent at earlier age in patients with higher genetic susceptibility (Figure 1, Figure 2).

Conclusions
Hyperinsulinemia and genetic susceptibility to hypertension are strong risk factors for prehypertension.

Funding Acknowledgement
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2020-901) to Al.K. Figure 1. Clinical markers of prehypertensionFigure 2. Genetic markers of prehypertension
The quality of plant-based dietary patterns affects the ten-year cardiovascular disease risk of participants with non-alcoholic fatty liver disease: highlights from a population-based cohort study
Authors: Kouvari M , Tsiampalis T , Chrysohoou C , Georgousopoulou E , Skoumas J , Mantzoros C S , Pitsavos C , Panagiotakos D B 
Published: October 2021

Abstract

Background/Introduction
Some plant-based diets like the Mediterranean diet have been suggested to have a beneficial impact on liver disease. However, the quality of plant-based diets – in general – varies.

Purpose
The association between plant-based diet indices and non-alcoholic fatty liver disease (NAFLD) as well as their interaction on ten-year cardiovascular disease incidence was examined.

Methods
A prospective study was conducted during 2001–2012 studying n=1,514 males and n=1,528 females (aged &gt;18 years old) free of CVD. Healthy metabolic status was defines as absence of all NCEP ATP III (2005) metabolic syndrome components (excluding waist circumference). Follow-up CVD assessment (2011–2012) was achieved in n=2,020 participants (n=317 cases). Overall, healthful and unhealthful plant-based dietary indices (PDI, hPDI and uPDI) were created through a standard procedure; hPDI was principally characterized by increased consumption of fruits/vegetables, whole grains, nuts, legumes, oils, tea/coffee while uPDI was related with increased intake of juices, sweetened beverages, refined grains, potatoes and sweets. NAFLD was defined according to validated liver steatosis indices.

Results
In total, n=707 (35%) participants presented NAFLD at baseline. Ranking from 1st to 3rd PDI tertile, NAFLD prevalence was 40.3%, 35.6% and 30.9%, respectively (p=0.04). Multiadjusted analysis revealed significant inverse associations between PDI and NAFLD prevalence [Odds Ratio (OR) (3rd vs. 1st tertile)=0.60 95% Confidence Interval (95% CI) (0.35, 0.92)] as well as hPDI [OR (3rd vs. 1st tertile) = 0.75 95% CI (0.64, 0.89)]. On the other side, increased uPDI had a positive association with NAFLD prevalence [OR (3rd vs. 1st hPDI tertile) = 1.22 95% CI (1.05, 1.34)]. NAFLD predicted CVD in multi-adjusted model [Hazard Ratio (HR) = 1.35, 95% CI (1.08, 2.10)]. Subgroup analyses according to participants' adherence to overall, healthy and unhealthy plant-based patterns revealed that this observation remained significant in the following cases: participants in the 1st PDI tertile, [HR=1.40, 95% CI (1.15, 2.09)] and participants in the 1st hPDI tertile [HR=1.47, 95% CI (1.22, 2.12)].

Conclusions
Lower adherence to plant-based diet was associated with substantially higher long-term CVD risk for a NAFLD individual. Most importantly, the healthy or unhealthy food choices within this pattern seemed to determine liver steatosis progression and in turn cardiometabolic health.

Funding Acknowledgement
Type of funding sources: None.
Marketing mortality? Healthy vs. unhealthy food in television advertising
Authors: Ikram M I , Hill K H , Williams K 
Published: October 2021

Abstract

Background
Cardiovascular disease has been the leading killer of Americans since the Spanish flu pandemic of 1918, despite recent COVID-19 mortality. During this global pandemic, the social distancing and stay-at-home requests, there was increased television (TV) engagement, and media marketing has become more impactful in modifying consumer behaviors.

Purpose
We evaluated the healthfulness of food marketing in the United States (US), based on TV commercials most frequently aired on American primetime networks during the COVID-19 pandemic.

Methods
We reviewed a total of 104 TV commercials between 2020–2021 on network and cable programs dividing them into 4 categories: 1) fast-food chains, 2) brand-recognized individual items, 3) grocery chains, and 4) home-delivery meals. The food items displayed in each commercial were recorded and scored based on the previously validated healthful versus unhealthful nutrition scoring system (Sajita, et al., JACC 2017), assigning either positive or negative values for each food item in the commercial.

Results
We found that 58% of the commercials advertised food from fast-food chains (mean score = −2.82, indicating an average of nearly 3 more unhealthy items than healthy items per commercial), 27% were brand-recognized individual items (−0.86), 9% were grocery chains (−0.90), and 6% were for home-delivery meals (−0.33), with significant differences noted between fast-food and individual items, home deliveries and grocery chains (each p&lt;0.0001).

Conclusions
This study demonstrated that commercial TV in the US routinely promotes the consumption of foods that are known in published medical literature to be unhealthy, particularly those underpinning cardiovascular disease and its risk factors. In order to prevent an increase in cardiovascular mortality during and after this global pandemic, we suggest regulation and or legislation to curtail the frequency and/or content of these commercials, and consider a ban on such advertising to children, similar to that previously employed in Canada and the European Union.

Funding Acknowledgement
Type of funding sources: None.
Combined cardiac risk factors predict COVID-19 related mortality and the need for mechanical ventilation in Coptic Clergy
Authors: Henein M Y , Bytyci I , Nicoll R , Sheneuda R , Ayad S , Cameli M , Vancheri F 
Published: October 2021

Abstract

Background and aims
The clinical adverse events of COVID-19 among clergy worldwide have been found higher than among ordinary communities, probably because of the nature of their work. The aim of this study, was to assess the impact of cardiac risk factors on COVID-19-related mortality and the need for mechanical ventilation in Coptic clergy.

Methods
Of 1576 Coptic clergy participating in the COVID-19-Clergy study, serving in Egypt, USA and Europe, 213 had the infection and were included in this analysis. Based on the presence of systemic arterial hypertension (AH), participants were divided into two groups: Group-I, Clergy with AH (n=77) and Group-II, without AH (n=136).Participants' demographic indices, cardiovascular risk factors, COVID-19 management details and related mortality were assessed.

Results
Clergy with AH were older (p&lt;0.001), more obese (p=0.04), had frequent type 2 diabetes (DM) (p=0.001), dyslipidemia (p=0.001) and coronary heart disease (CHD) (p=0.04) compared to those without AH. COVID-19 treatment at home, hospital or in intensive care did not differ between the patient groups (p&gt;0.05 for all). Clergy serving in Northern and Southern Egypt had a higher mortality rate compared to those from Europe and the USA combined (5.22%, 6.38%, 0%; p=0.001). The impact of AH on mortality was significant only in Southern Egypt (10% vs. 3.7%; p=0.01) but not in Northern Egypt (4.88% vs. 5.81%; p=0.43).
In multivariate analysis, CHD OR 1.607 [(0.982 to 3.051); p=0.02] and obesity, OR 3.403 [(1.902 to 4.694); p=0.04]predicted COVID-19 related mortality. A model combining cardiac risk factors (systolic blood pressure (SBP) ≥160 mmHg, DM, obesity, dyslipidemia and history of CHD), was the most powerful independent predictor of COVID-19-related mortality, OR 4.813 [(2.011 to 7.017); p=0.008]. The same model also proved the best independent multivariate predictor of mechanical ventilation OR 1.444 [(0.949 to 11.88); p=0.001].

Conclusion
In Coptic clergy, the cumulative impact of risk factors is the most powerful predictor of mortality and the need for mechanical ventilation in Coptic clergy.

Funding Acknowledgement
Type of funding sources: None.
Cardiac biomarkers as prognosticators among SARS-CoV-19 patients in a tertiary hospital in Philippines
Authors: Ong R , Chacon C , Javier S 
Published: October 2021

Abstract

Background
There is overwhelming volume of confirmed cases of COVID-19, despite this numerous knowledge gaps remain in the diagnosis, management, and prognostication of this novel coronavirus infection, making prevention and control a challenge.

Methods
This retrospective cohort study included patients with real-time reverse transcriptase polymerase chain reaction (rRT-PCR)-confirmed COVID-19. Binary logistic regression was used to determine the association between the cardiac biomarkers and in-hospital mortality. ROC, AUC, and cutoff analyses were used to determine optimal cutoff values for the cardiac biomarkers.

Results
A total of 90 subjects with a complete panel of cardiac biomarkers out of the 224 rRT-PCR confirmed cases were included. The median age was 57 years (IQR, 47–67 years), majority were males. Sixty-six (77.6%) subjects survived while 19 (22.4%) expired. The most common presenting symptom was fever (75.6%), and the most common comorbidity was hypertension (67.8%). Spearman rho correlation analysis showed moderate positive association of high sensitivity troponin I (hsTnI) with in-hospital mortality (R, 0.434, p = &lt;0.001). Multivariate binary logistic regression analysis showed that creatine kinase and hsTnI were independently associated with in-hospital mortality (OR, 4.103 [95% CI, 1.241–13.563], p=0.021; and OR, 7.899 [95% CI, 2.430–25.675], p=0.001, respectively). ROC curve analysis showed that hsTnI was a good predictor for in-hospital mortality (AUC, 0.829 [95% CI, 0.735–0.923], p = &lt;0.001) and that creatine kinase was a poor predictor (AUC, 0.677 [95% CI, 0.531–0.823], p=0.018). Optimal cutoff point derived from the ROC curve for hsTnI was 0.010 ng/ml (J, 0.574) with a sensitivity of 84% (TPR, 0.842 [95% CI, 0.604–0.966]), specificity of 73% (TNR, 0.732 [95% CI, 0.614–0.386]), and an adjusted negative predictive value of 99% (Known prevalence*adjusted NPV, 0.989), a positive likelihood ratio of 20% (LR+, 3.147 [95% CI, 2.044–4.844]) and a negative likelihood ratio of 30% (LR−, 0.216 [95% CI, 0.076–0.615]).

Conclusion
High sensitivity troponin I level was a good tool with a very high negative predictive value in significantly predicting in-hospital mortality among rRT-PCR positive COVID-19 patients.

Funding Acknowledgement
Type of funding sources: None. ROC Curve
Higher plasma level of small dense low-density lipoprotein cholesterol in ST-segment-elevation myocardial infarction patients with plaque rupture
Authors: Arai T , Sekimoto T , Mori H , Sakai R , Tanaka H , Oishi Y , Ogura K , Nomura K , Sakai K , Tsujita H , Kondo S , Koba S , Shinke T 
Published: October 2021

Abstract

Aim
The aim of this study was to compare small dense low-density lipoprotein cholesterol (sd-LDL-c) and various lipid markers between patients exhibiting plaque rupture (PR) in the culprit lesions evaluated by optical coherence tomography (OCT) imaging and those without PR in ST-segment elevation myocardial infarction (STEMI) patients.

Methods
We studied consecutive 60 de novo culprit lesions in 60 patients with STEMI who underwent pre-intervention OCT. PR was defined as a plaque containing a cavity that had overlying residual fibrous caps. Plasma sd-LDL-c was measured directly by homogeneous assay at the time of primary percutaneous coronary intervention.

Results
The patients were classified into PR (n=40, 66.7%) or non-PR (n=20, 33.3%). There were no significant differences in low-density lipoprotein cholesterol (LDL-c), non-high-density lipoprotein cholesterol (non-HDL-c) and pre-admission statin therapy between two groups (135.1±38.0 mg/dL vs 129.2±43.8 mg/dL; p=0.35, 157.1±37.4 mg/dL vs 143.0±37.7 mg/dL; p=0.24, 15.0% vs 20.0%; p=0.93). However, sd-LDL-c level was significantly higher in patients with PR than those with non-PR (44.0±18.1 mg/dL vs 28.0±9.3 mg/dL; p=0.0005). On multiple logistic regression analysis, sd-LDL-c was an independent predictor of PR (odds ratio, 1.14 per 1 mg/dL; p=0.0063).

Conclusion
Sd-LDL-c was significantly associated with PR of the culprit lesion in patients with STEMI.

Funding Acknowledgement
Type of funding sources: None.
Specific risk factors profile and abstinence rate of female smokers at high cardiovascular risk from the nationwide smoking cessation services cohort CDT-net
Authors: Allagbe I , Thomas D , Airagnes G , Limosin F , Chague F , Zeller M , Le Faou A L 
Published: October 2021

Abstract

Background
In women, smoking is particularly harmful to the cardiovascular (CV) system, and smoking cessation (SC) is a key issue for CV prevention.

Objectives
From a large nationwide database on subjects who visited SC services between 2001 and 2018, we aimed to describe the profile and abstinence rate among female smokers at high CV risk.

Methods
Observational study from the French CS services cohort CDT-net. Inclusion criteria were age ≥18 years, and ≥1 CV risk factor (i.e. body mass index ≥25 kg/m2, hypercholesterolemia, diabetes, hypertension, history of stroke, myocardial infarction or angina pectoris. Abstinence (≥28 consecutive days) was self-reported, and confirmed by measurement of exhaled carbon monoxide &lt;10 ppm.

Results
Among 37,949 smokers, 16,492 (43.5%) were women. Compared to men, women were 3-y younger (48 vs 51 y, p&lt;0.001) and more educated (≥ Bachelor degree: 55 vs 45%, p&lt;0.001). The burden of CV risk factors was high in women and men: hypercholesterolemia (30% vs 33% p&lt;0.001), hypertension (23% vs 26%, p&lt;0.001) and diabetes (10 vs 13%, p&lt;0.001). Compared to men, women suffered more often from obesity (27 vs 20%, p&lt;0.001), respiratory diseases (COPD: 24% vs 21%, p&lt;0.001; asthma: 16 vs 9%, p&lt;0.001) and anxio-depressive symptoms (37.5 vs 26.5%, p&lt;0.001). Although women were less nicotine dependent than men, their abstinence rate was lower (52 vs 55%, p&lt;0.001).

Conclusion
Female smokers who visited SC services not only presented very high CV risk profile, but also elevated rates of lung diseases and anxio-depressive symptoms. Our findings highlight the need to strengthen CV prevention strategies, through comprehensive gender-tailored SC interventions.

Funding Acknowledgement
Type of funding sources: Public Institution(s). Main funding source(s): IReSP and INCa through a call for doctoral grants launched in 2019
Metabolic syndrome is related to vascular structural alterations but not to functional one both in hypertensives and healthy subjects
Authors: Leidi F , Maloberti A , Bombelli M , Monticelli M , Ruzzenenti G , Biolcati M , Giani V , De Chiara B , Grassi G , Giannattasio C 
Published: October 2021

Abstract

Background
Metabolic Syndrome (MS) has been related to an impairment in arterial structural and functional properties with heterogeneous results.

Purpose
In this study we focused on the effects of MS on arterial carotid-femoral Pulse Wave Velocity (PWV) and common carotid Intima Media Thickness (IMT) in two different populations, one of hypertensive patients and one of healthy controls.

Methods
We enrolled 816 consecutive hypertensive (HT) and 536 healthy controls. Vascular structural (IMT) and functional (PWV) properties were evaluated. NCEP-ATP-III criteria were used for diagnosis of MS.

Results
MS was diagnosed in 26.9% and 6.9% in hypertensive and control subjects, respectively. PWV was similar in controls with and without MS (7.7±1.9 vs 7.6±1.1 m/s, p=0.69), while IMT was higher in controls with than those without MS (0.64±0.18 vs 0.57±0.13 mm, p=0.02). Hypertensives with MS were older (57.9±12.2 vs 52.7±14.1 years, p&lt;0.001) and showed higher PWV (9.0±2.3 vs 8.4±2.1 m/s, p=0.001) and IMT (0.72±0.22 vs 0.65±0.17 mm, p&lt;0.001) than those without MS, however at the age-adjusted analysis only the difference in IMT was confirmed (p=0.007). Regression models showed that MS was an independent determinant of IMT in both controls (β=0.08, p=0.03) and hypertensives (β=0.08, p=0.01), but not of PWV either in controls (β=0.006, p=0.886 and β=0.04, p=0.19, respectively).

Conclusions
The main finding of our work is that MS is a significant determinant of IMT while this is not the case for PWV. This result has been confirmed both in hypertensive subjects and in healthy controls.

Funding Acknowledgement
Type of funding sources: Public hospital(s). Main funding source(s): ASST Grande Ospedale Metropolitano Niguarda
Effects of physical prehabilitation on markers of endothelial function in patients undergoing elective coronary artery bypass grafting
Authors: Argunova Y , Belik E , Gruzdeva O , Barbarash O 
Published: October 2021

Abstract

Purpose
To evaluate the effects of preoperative exercise training on the perioperative serum levels of asymmetric dimethylarginine (ADMA) and endothelin-1 (ET-1) in patients with stable coronary artery disease (CAD).

Methods
78 male patients with stable coronary artery disease referred to elective on-pump CABG were screened and randomized either to receive prehabilitation, or routine preoperative management without training. Group 1 (n=43, age 61.5 [55; 65] years) patients underwent preoperative exercise training (treadmill sessions at 80% of peak oxygen uptake (VO2peak) intensity for 5–10 days), whereas group 2 (n=35, age 63.0 [56; 66] years) received routine preoperative management without training.
Levels of endothelial function (ADMA and ET-1) were measured using enzyme immunoassay in the preoperative period of CABG before exercise training, the day before surgery, and in the postoperative period on days 5–7.
Logistic regression analysis was used to determine significant risk factors contributing to postoperative complications in the early postoperative period.
Statistical analysis was performed using the Statistica 10.0 software (Statsoft, USA).

Results
Patients from both study groups did not differ in the main preoperative clinical and demographic parameters. They had similar comorbid profile and were also comparable in terms of the intraoperative parameters. No differences in baseline echocardiography and cardiopulmonary exercise testing were reported.
By the end of the exercise training, group 1 patients had a significantly lower level of ADMA than patients from group 2 without prehabilitation (p=0.01). Correlation analysis reported a direct correlation between the levels of ADMA and ET-1 the day before surgery (ρ = 0.28, P=0.04) in the absence of significant intergroup differences in ET-1 levels.
Stepwise logistic regression adjusted for comorbidities (chronic bronchopulmonary disease) and intraoperative risk factors (aortic cross-clamp time) reported a correlation of the pre-existing diabetes with an increased risk of complications in the early postoperative period (OR 12.3, 95% CI [1, 18–127.6], p=0.03). Elevated ET-1 levels also increased the risk of complications (OR 10.7, 95% CI [1.1–105.2], p=0.03), whereas preoperative exercise training reduced the risk of postoperative complications (OR 0.1, 95% CI [0.01–0.82], p=0.02).

Conclusion
Our findings indicate favorable effects of prehabilitation on the improvement of endothelial function and prevention of the complications in the early postoperative period.

Funding Acknowledgement
Type of funding sources: Public Institution(s). Main funding source(s): Fundamental topic No. 0546-2019-0003
Sex differences in pre-hospital analgesia and outcomes in patients presenting with acute coronary syndromes
Authors: Nan Tie E , Fernando H , Nehme Z , Dinh D , Andrew E , Brennan A , Zaman S , Liew D , Stephenson M , Lefkovits J , Peter K , Duffy S J , Shaw J , Smith K , Stub D 
Published: October 2021

Abstract

Background
Opioid analgesia remains the mainstay of pain management in acute coronary syndromes (ACS). Significant sex differences persist in ACS presentation, management and outcomes, but the impact of sex-differences on pre-hospital pain management of ACS with opioids is unknown. There is increasing awareness of the importance of pre-hospital factors in ACS, as well as emerging concerns with opioid use impairing the gastrointestinal absorption of oral P2Y12 inhibitors.

Purpose
This study examined if sex-differences in pre-hospital pain scores, opioid administration and clinical outcomes exist in ACS patients.

Methods
Patients presenting with ACS via ambulance (2014–2018) that underwent percutaneous coronary intervention (PCI) were prospectively collected via the Victorian Cardiac Outcomes Registry (VCOR), the Melbourne Interventional Group (MIG), and linked to the Ambulance Victoria database. The primary outcome was 30-day major adverse cardiac events (MACE). Secondary outcomes were descriptive analyses of pre-hospital pain score, intravenous morphine equivalent analgesic dosing, plus predictors of MACE and Thrombolysis In Myocardial Infarction (TIMI) 0–1 flow pre-PCI using logistic regression.

Results
10,547 patients were included (female: 2,775 [26.3%]). Opioids were administered to 1,585 (57%) females and 5,068 (65%) males (p&lt;0.001). Adjusted 30-day MACE was similar between opioid groups in both sexes (female: OR 1.21, CI 0.82–1.79, p=0.34; male: OR 0.89, 0.68–1.16, p=0.40). Median pain score at presentation was 6 (IQR 4,8) for both sexes. Median opioid dose was 2.5 mg (IQR 0,10) in females and 5 mg (IQR 0,10) in males (p&lt;0.001), with similar pain relief achieved. Adjusted rates of TIMI 0–1 pre-PCI were higher in patients administered opioids (female: OR 2.83, CI 2.14–3.56, p&lt;0.001; male: OR 2.95, CI 2.49–3.49, p&lt;0.001).

Conclusions
Female patients undergoing PCI received less opioid analgesia, but no sex-differences in pre-hospital pain scores were seen. Opioid administration was associated with impaired antegrade flow in the culprit artery in both sexes, but not short-term MACE. Randomised trials evaluating the clinical implications of opioid administration in ACS with sex subgroup analyses are needed to guide clinical practice.

Funding Acknowledgement
Type of funding sources: Public Institution(s). Main funding source(s): Melbourne Interventional GroupVictorian Cardiac Outcomes Registry