bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is probabilistic cuing of visual search an inflexible attentional habit? A meta-analytic review
Authors: Giménez-Fernández Tamara , Luque David , Shanks David R. , Vadillo Miguel A. 
Published: November 2021

Abstract﻿In studies on probabilistic cuing of visual search, participants search for a target among several distractors and report some feature of the target. In a biased stage the target appears more frequently in one specific area of the search display. Eventually, participants become faster at finding the target in that rich region compared to the sparse region. In some experiments, this stage is followed by an unbiased stage, where the target is evenly located across all regions of the display. Despite this change in the spatial distribution of targets, search speed usually remains faster when the target is located in the previously rich region. The persistence of the bias even when it is no longer advantageous has been taken as evidence that this phenomenon is an attentional habit. The aim of this meta-analysis was to test whether the magnitude of probabilistic cuing decreases from the biased to the unbiased stage. A meta-analysis of 42 studies confirmed that probabilistic cuing during the unbiased stage was roughly half the size of cuing during the biased stage, and this decrease persisted even after correcting for publication bias. Thus, the evidence supporting the claim that probabilistic cuing is an attentional habit might not be as compelling as previously thought.
Putting the individual into reliability: Bayesian testing of homogeneous within-person variance in hierarchical models
Authors: Williams Donald R. , Martin Stephen R. , Rast Philippe 
Published: November 2021

AbstractMeasurement reliability is a fundamental concept in psychology. It is traditionally considered a stable property of a questionnaire, measurement device, or experimental task. Although intraclass correlation coefficients (ICC) are often used to assess reliability in repeated measure designs, their descriptive nature depends upon the assumption of a common within-person variance. This work focuses on the presumption that each individual is adequately described by the average within-person variance in hierarchical models. And thus whether reliability generalizes to the individual level, which leads directly into the notion of individually varying ICCs. In particular, we introduce a novel approach, using the Bayes factor, wherein a researcher can directly test for homogeneous within-person variance in hierarchical models. Additionally, we introduce a membership model that allows for classifying which (and how many) individuals belong to the common variance model. The utility of our methodology is demonstrated on cognitive inhibition tasks. We find that heterogeneous within-person variance is a defining feature of these tasks, and in one case, the ratio between the largest to smallest within-person variance exceeded 20. This translates into a tenfold difference in person-specific reliability! We also find that few individuals belong to the common variance model, and thus traditional reliability indices are potentially masking important individual variation. We discuss the implications of our findings and possible future directions. The methods are implemented in the R packagevICC
Molecular and proteomic signatures associated with preservation related graft injury: insight from human liver normothermic machine perfusion (NMP)
Authors: Dengu Fungai 
Published: November 2021

Fungai Dengu1; Sadr Shaheed1; Letizia Lo Faro1; Adam Thorne1; Honglei Huang1; Peter Friend1,Rutger Ploeg1.
1. Oxford Organ Perfusion Lab, Nuffield Department of Surgical Sciences and Oxford BiomedicalResearch Centre, University of Oxford, Oxford, UK

BackgroundContinuous liver NMP is a novel technology associated with safe extension of organ preservation time, increased organ utilisation and reduced early graft injury1. Increasingly, it is utilised as a ‘back to base’ application with cold storage for organ transport and NMP initiated at the implanting centre prior to transplantation2. We aimed to evaluate the impact of additional cold ischaemia time (CIT) on the proteomic and molecular signature of NMP livers.
Methods Liver tissue samples (N= 57) from a prospective clinical trial of ‘back to base’ NMP were analysed. Collection occurred at the end of cold storage (LT1), end of NMP/total preservation (LT2) and after organ reperfusion (LT3). Unbiased, label-free-quantitative (LFQ) proteomic analysis was conducted using liquid chromatography with tandem mass spectrometry and trapped ion mobility spectrometry (TIMS) to time-of-flight (TOF) mass analysis (LC-MS/MS TIMS-TOF). Differential expression and Gene Ontology/Pathway analysis were performed.
Results LT2 samples with prolonged CIT (>6hr) prior to NMP had significant differential expression of proteins associated with liver-specific oxidative stress, cellular haemostasis and removal of damaged or misfolded proteins (e.g. CYP3A5, PSMB1). LT3 samples, similarly, had reduced proteins involved in autophagy and cell-cycle regulation (e.g. STBD1, CD2AP, GADD45GIP1,) and increased expression of proteins involved in neutrophil chemotaxis, adhesion and aggregation (e.g. S100A9).
Discussion The molecular signature of grafts at LT2 and LT3 varies depending on the length of CIT prior to NMP. Further exploration of the molecular signatures associated with preservation related graft injury is required to determine how best to apply this novel technology clinically. References:
1. Nasralla, D. et al. A randomized trial of normothermic preservation in liver transplantation. Nature 557, 50–56 (2018).2. Ceresa, C. D. L. et al. Transient Cold Storage Prior to Normothermic Liver Perfusion May Facilitate Adoption of a Novel Technology. Liver Transplant. lt.25584 (2019).doi:10.1002/lt.25584
The role of biased calcium-sensing receptor signalling in urinary calcium excretion and kidney stone disease
Authors: Goldsworthy Michelle 
Published: November 2021

Michelle Goldsworthy1,2, Asha Bayliss2, Anna Gluck2, Akira Wiberg3, Benjamin Turney1, DominicFurniss3, Rajesh Thakker2, Sarah Howles1,2
1Nuffield Department of Surgical Sciences, University of Oxford, United Kingdom.2Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, UnitedKingdom.3Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Universityof Oxford, United Kingdom.

Nephrolithiasis is a major health burden with a poorly understood pathogenesis. We conducted a genome-wide association study in British and Japanese populations identifying twenty nephrolithiasis-associated loci. Mutations in the calcium-sensing receptor (CaSR) cause disorders of calcium homeostasis and five identified loci (DGKD, DGKH, WDR72, GPIC1 and BCR) were predicted to influence CaSR-signalling.
In a validation population, we demonstrated that genotype at the DGKD-associated locus correlated with urinary calcium excretion but not serum calcium concentration. In vitro studies demonstrated that knockdown and overexpression of DGKD resulted in biased CaSR-signalling. Thus, treatment of CaSR-expressing HEK cells with DGKD-targeted siRNA (DGKD-KD), resulted in decreased MAPK responses to alterations in extracellular calcium concentration [Ca2+]e, as assessed by SRE-reporter and ERK-phosphorylation (pERK) assays, when compared to cells treated with scrambled siRNA (WT) but without alteration in intracellular calcium responses [Ca2+]i as assessed by NFAT-reporter and Fluo-4 calcium assays (SRE maximal response DGKD-KD =5.28 fold change vs. WT=7.20 p=0.0065, pERK maximal response DGKD-KD=24.77, vs. WT= 39.46 fold change, p=0.0056). Conversely, DGKD overexpression (DGKD-OE) increased MAPK responses but suppressed [Ca2+]i responses to alterations in [Ca2+]e (SRE maximal response DGKD-OE =14.13 fold change vs. WT=9.06 fold change, p=0.01; NFAT maximal response DGKD-OE=13.67 fold change vs WT=59.16 fold change, p=0.0001).
Our results demonstrate that alterations in DGKD expression cause biased CaSR-signalling. This biased signalling may provide an explanation for the correlation of genotype at the DGKD-associated locus with urinary calcium excretion but not serum calcium concentration. Our findings suggest that biased CaSR-signalling may be a common cause of nephrolithiasis.
Kepler-411 Star Activity: Connection between Starspots and Superflares
Authors: Araújo Alexandre , Valio Adriana 
Published: November 2021

Abstract
Stellar magnetic activity, just like that of the Sun, manifests itself in the form of flares and spots on the surface of the star. In the solar case, the largest flares originate from large active regions. In this work, we present a study of the activity of the star Kepler-411, including spot modeling from planetary transits. Our goal was to search for a connection between the area of starspots with the energy of superflares produced by this star. Kepler-411 is a K2V-type star with an average rotation period of 10.52 days, radius of 0.79 R
⊙, and a mass of 0.83 M
⊙, which was observed by the Kepler satellite for about 600 days. Transit mapping allowed for the characterization of 198 starspots with estimates of their radius and temperature. Kepler-411 starspots had an average radius of (17 ± 7) × 103 km and a mean temperature of 3800 ± 700 K. Visual inspection of the light curves of Kepler-411 yields the identification of 65 superflares. The detected superflares lasted from 8 to 260 minutes and their energy varied from 1033–1035 ergs. The power-law index of the flare frequency distribution as a function of energy is (−2.04 ± 0.13) for the flare on Kepler-411. A positive correlation between the area of starspots and the energy of superflares was found when considering the averages taken every 16–35 days, with the highest correlation occurring for averages every 21 days. This timing is probably related to the lifetime of the Kepler-411 spots.
X-Ray Evidence Against the Hypothesis that the Hyperluminous z = 6.3 Quasar J0100+2802 is Lensed
Authors: Connor Thomas , Stern Daniel , Bañados Eduardo , Mazzucchelli Chiara 
Published: November 2021

Abstract
The z = 6.327 quasar SDSS J010013.02+280225.8 (hereafter J0100+2802) is believed to be powered by a black hole more massive than 1010
M
⊙, making it the most massive black hole known in the first billion years of the universe. However, recent high-resolution ALMA imaging shows four structures at the location of this quasar, potentially implying that it is lensed with a magnification of μ ∼ 450 and thus its black hole is significantly less massive. Furthermore, for the underlying distribution of magnifications of z ≳ 6 quasars to produce such an extreme value, theoretical models predict that a larger number of quasars in this epoch should be lensed, implying further overestimates of early black hole masses. To provide an independent constraint on the possibility that J0100+2802 is lensed, we reanalyzed archival XMM-Newton observations of the quasar and compared the expected ratios of X-ray luminosity to rest-frame UV and IR luminosities. For both cases, J0100+2802's X-ray flux is consistent with the no-lensing scenario; while this could be explained by J0100+2802 being X-ray faint, we find it does not have the X-ray or optical spectral features expected for an X-ray faint quasar. Finally, we compare the overall distribution of X-ray fluxes for known, typical z ≳ 6 quasars. We find a 3σ tension between the observed and predicted X-ray-to-UV flux ratios when adopting the magnification probability distribution required to produce a μ = 450 quasar.
Sites of violence and their communities: Critical memory studies in the post-human era (Kraków, 24–25 September 2019)
Authors: Szczepan Aleksandra 
Published: November 2021

This discussion gathers voices of an international group of researchers and practitioners from various disciplines and institutions who focus on diverse aspects of sites of past violence in their work: archaeology, history, ethics, literature and art, curatorial practices, oral history, education and commemoration. The debate, which took place during the conference “Sites of Violence and Their Communities: Critical Memory Studies in the Post-Human Era” in Kraków in September 2019, itself centres on six main topics: the question of archives of uncommemorated killing sites; research methodology; the position of the researchers themselves; the problem of complicity during conflict and the right to be a witness to past crimes; the place of the Righteous Among the Nations within Polish collective memory and the international debate on the Holocaust; and, finally, new ways of commemoration and education about mass violence.
Participants: Katarzyna Bojarska, Michał Chojak, Ewa Domańska, Zuzanna Dziuban, Karolina Grzywnowicz, Aleksandra Janus, Karina Jarzyńska, Maria Kobielska, Rob van der Laarse, Bryce Lease, Erica Lehrer, Jacek Leociak, Tomasz Łysak, Tomasz Majkowski, Christina Morina, Matilda Mroz, Adam Musiał, Agnieszka Nieradko, Łukasz Posłuszny, Roma Sendyka, Caroline Sturdy Colls, Katarzyna Suszkiewicz, Aleksandra Szczepan, Krijn Thijs, Jonathan Webber, Anna Zagrodzka, Tomasz Żukowski
La philía politiké como amor mundi: La recepción de Hannah Arendt de la amistad política de Aristóteles
Authors: Goyenechea Elisa 
Published: November 2021

Este trabajo examina la recepción de la philía aristotélica por parte de Hannah Arendt. Primero, exponemos las notas de la philía en la Ética a Nicómaco y la proyección política de la amistad como synaísthesis. Segundo, argumentamos que tanto en un destacado fragmento de “Truth and Politics”, como en la Lectures on Kant’s Political Philosophy, Arendt termina de esclarecer su noción de amistad como lazo mundano y político. Allí no alude a Aristóteles, sino a Kant y a sus reflexiones sobre el sentido del gusto y el sensus communis.
Braidotti: por una ética de Tamagotchis, cigarrillos y esquizofrenia
Authors: Vega Castro Diego Enrique 
Published: November 2021

El siguiente trabajo se propone desarrollar las consecuencias teóricas y prácticas, presupuestos filosóficos y aporías intelectuales a las que se enfrenta el lector de la autora Rosi Braidotti en su planteamiento sobre una ética del devenir y las relaciones éticas de un sujeto transpuesto o poshumano. Se toman para ello dos ejemplos casi marginales de su libro Transposiciones, a saber, las relaciones humanas desarrolladas con los Tamagotchis y otras tecnologías, y la así llamada “ética del penúltimo cigarrillo” enmarcada en la “transposición de la muerte”. El planteamiento de Braidotti será examinado y criticado a la luz de autores (especialmente Slavoj Zizek y Pierre Manent) que han reflexionado, también de manera casi marginal, sobre los mismos problemas y su contextualización en la filosofía política contemporánea y moderna. Se pretende mostrar que la postura de la autora presume de ser esquizofrénica y, en efecto, nos brinda un planteamiento lamentablemente esquizofrénico.
L’articolo del romanzo ‘Figlio’ della diatesi passiva? Un’inpotesi inspirata a montague e sviluppata in chiave contrastive slavo-romanza
Authors: Spinozzi Monai Liliana 
Published: November 2021

Romanzo vs slavo= passivo vs attivo = Art(icolo) vs Des(inenza) = AUX "avere" vs "essere". È in corso un vivace dibattito sulla categoria semantica della definitezza (Def) e sul grado e le modalità del suo esplicitarsi come determinante. Nel presente lavoro ci concentreremo sulla categoria dell 'articolo (Art), in prima istanza su quello Det(erminativo), elaborando alcuni spunti ricavati da disamine sul­ l'argomento compiute su versanti differenti, come quello dell'indoeuropeistica (p. es. Nocentini 1996), della germanistica (p. es. Ramat 1984b) e della slavistica (p. es. Benacchio l 996a e 1996b; Gebert 1996, Parenti 1996). Interessanti spunti di riflessio L’articolo del romanzo ‘Figlio’ della diatesi passiva? Un’inpotesi inspirata a montague e sviluppata in chiave contrastive slavo-romanza ne sono offerti anche da opere di carattere monografico sulla deissi (cfr. Vanelli 1992), sulla sintassi dei determinanti (G. Giusti 1993), sull'articolo italiano (cfr. i due voll. di Korzen 1996), o da rassegne come quella relativa alle diverse interpretazioni del rapporto Nome/Riferimento (Bersani-Berselli 1995)- intendendo per Nome il SN rappresentato dalla sola testa nominale - o quella sul passivo nelle lingue slave (Fici-Giusti 1994), che supporta non poco l'ipotesi da cui muovono queste pagine.
Typologie de la pêche de la langouste verte Panulirus regius, De Brito Capello, 1864 sur le littoral de la Côte d’Ivoire (Afrique de l’Ouest)
Authors: Konan Ida Akissi , Etchian Olivier Assoi , Kouame Basile Kouakou , Yapi Jean-Noel , Loukou Angelina Gbohono , Kadjo Vincent 
Published: November 2021

En Côte d’Ivoire, la langouste fait partir des crustacés présents dans les captures de la pêche maritime artisanale. Cependant, aucune donnée scientifique n’est disponible quant aux acteurs de la pêche de cette protéine. Ainsi, la présente étude a pour objectif de caractériser les acteurs de la pêche à la langouste verte Panulirus regius (De Brito Capello, 1864) pratiquée au niveau de la Zone Economique Exclusive de la Côte d’Ivoire. L’étude a nécessité une enquête le long du littoral sur un effectif de 60 pêcheurs de langouste. Les résultats ont montré que la pêche langoustière est pratiquée essentiellement par les Ivoiriens et les Ghanéens. De plus, la tranche d’âge dominante chez ces pêcheurs est comprise entre 30 et 45 ans chez les Ivoiriens et Ghanéensavec des proportions de 20% et 25%, respectivement. Au niveau de la quantité de la langouste verte pêchée, la grande saison froide a enregistré la plus grande quantité de langoustes capturées.

English title: Fishing typology of the green lobster Panulirus regius, De Brito Capello, 1864 along the coast of Côte d’Ivoire (West Africa)
In the Côte d’Ivoire, lobster is part of the crustaceans present in the catches of artisanal maritime fishing. However, no scientific data is available on the actors of the fishery of this protein. Thus, the objective of this study is to characterize the actors of the green lobster Panulirus regius (De Brito Capello, 1864) fishery practised in the Exclusive Economic Zone of the Côte d’Ivoire. The study required a survey along the coastline of 60 lobster fishermen. The results showed that green lobster fishing is mainly practised by citizens of Côte d’Ivoire and Ghana. Fishermen who practised this activity were aged between 30 and 45 years old with percentages of 20% and 25% for citizens of Côte d’Ivoire and Ghana, respectively. In terms of the quantity lobster captured, the largest quantity was recorded on the great cold season.
Evaluation de la toxicité d’un aphrodisiaque ivoirien d’origine naturelle (aphro) chez le rat
Authors: Gbogbo Moussa , Kouadio Rufin Yao , Aboli Félicité Tano-bla , Kone Mama , Kporou Elisée Kouassi , Yapo Paul Angoué 
Published: November 2021

L’usage des plantes à des fins thérapeutiques est très ancien. De nos jours encore, elles sont utilisées par une frange partie de la population mondiale. La présente étude avait pour objectif d’étudier les effets toxiques de l'administration subaiguë d'un phytomédicament ivoirien Aphro vendu sur les marchés chez le rat Wistar albinos. Pour ce faire, le phytomédicament Aphro a été administré quotidiennement par voie orale à trois lots de rats, aux doses de 5,75 ; 11,5 et 23 mg/kg de poids corporel et cela pendant 28 jours. Le taux de croissance des rats, les paramètres hématologiques et biochimiques sanguins ont été étudiés. Les résultats de cette étude ont révélé qu’aux doses de 5,75 ; 11,5 et 23 mg/kg de poids corporel, le phytomédicament ne modifie pas de façon significative le taux d’accroissement de la masse corporelle et les paramètres hématologiques constitués du taux de globules rouges, de globules blancs, de plaquettes sanguines et le taux d’hémoglobine. Par ailleurs, des marqueurs hépatiques et lipidiques sériques des rats traités n'ont pas été perturbés par l’administration du phytomédicament comparativement au lot témoin. En revanche, la créatinine, l’un des marqueurs rénaux étudiés a connu une augmentation significative (p < 0,05) chez les rats traités avec le phytomédicament aux doses de 11,5 et 23 mg/kg de poids corporel par rapport au lot témoin. Cette étude a permis de montrer que l’usage prolongé et à doses élevées de Aphro pourrait entraîner des effets nocifs sur les reins.

English title: Assessment of the toxicity of an ivoirian natural aphrodisiac (aphro) on rat
The use of plants for therapeutic purposes is very old. Even today, they are used by a part of the world population. The objective of the present study was to evaluate the toxic effects of the subacute administration of an ivorian phytomedicine Aphro sold in the markets in the albino Wistar rat. To do this, the phytomedicine Aphro was administered orally daily to three batches of rats, at doses of 5.75; 11.5 and 23 mg/kg of body weight for 28 days. Rats' growth rate, blood haematological and biochemical parameters were studied. The results of this study showed that at doses of 5.75; 11.5 and 23 mg/kg of body weight, the phytomedicine does not significantly modify the rate of increase in body mass and the hematological parameters consisting of the level of red blood cells, white blood cells, blood platelets and the level hemoglobin. Furthermore, hepatic and serum lipid markers of the treated rats were not disturbed by the administration of the phytomedicine compared to the control group. In contrast, creatinine, one of the renal markers studied, experienced a significant increase (p <0.05) in rats treated with the phytomedicine at doses of 11.5 and 23 mg / kg of body weight compared to the batch witness. This study showed that prolonged use and in high doses of Aphro could cause harmful effects on the kidneys.