bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPERMANENCE / MUTABILITY: READING PERCY BYSSHE SHELLEY’S POETRY THROUGH BUDDHA
Authors: Hajjari Leila , Sarvestani Zahra Soltani 
Published: March 2021

As an ongoing phenomenon, the impermanence of the world has been observed by many people, both in ancient and modern times, in the East and in the West. Two of these authors are Gautama Buddha (an ancient, eastern philosopher from the 6th-5th centuries B.C.) and Percy Bysshe Shelley (a modern Western poet: 1792-1822). The aim of this paper is to examine in the light of Buddhist philosophy what impermanence means or looks in a selection of Shelley’s poems, after considering that this philosophy was not alien to the Europeans of the 18th and 19th centuries. Buddhism, seeing impermanence (anicca) as the foundation of the world, both acquiesces to it and urges the individuals to sway with its ebb and flow. Shelley mainly falters in the incorporation of the phenomenon into his mindset and his poems. However, he often shows a casual acceptance of it; and even, in a few cases, he presents it with a positive assessment.
Keywords: Buddhism, Shelley, impermanence, mutability, transience, anicca
CULTURAL ALIENATION AND LANGUAGE DISCONTINUITY IN LA MÉMOIRE TATTOUÉE
Authors: Miloud Rahmoun 
Published: March 2021

The question of Alienation is a core subject-matter of human conditioning in the present era. Therefore, it is natural that a controversial issue like alienation should leave such an indelible influence upon contemporary literature. The question of Alienation, in its different manifestations, has been conceptualized and discussed, most importantly, within the existentialistic literary perspective. Due to its historical and socio-cultural conditions, the African as well as the Maghrebian literature could not shy away from the influence of alienation, understood as an identity loss and as a sense of inferiority, experienced either before or after the contact with the Other. The dispossessed personality's search for identity is a commonplace theme in modern fiction. The present paper will discuss the different nuances of the word alienation and analyze this theme in La Mémoire Tattouée (1971), a Moroccan literary text written in French by Abdelkebir Khatibi. The aim is to show how language discontinuity stands as a cause that creates a sense of inferiority, subordination, and alienation.
Key words: identity, alienation, inferiority, existentialism, La Mémoire Tatuée, Abdelkebir Khatibi
ENTRETIEN AVEC JEAN-PIERRE BROUILLAUD SUR MA VIE AVEC CONTUMACE (2018)
Authors: Doustin Elisabeth 
Published: March 2021

Entretien avec l’écrivain français Jean-Pierre Brouillaud, mené par des étudiants du lycée Jean Moulin (Saint-Amand-Montrond), sous la responsabilité d’Elisabeth Doustin, leur professeur de littérature. Après une introduction à l’expérience didactique, à la biographie de Monsieur Brouillaud et à son oeuvre variée, l’auteur est interrogé à propos de son roman Ma vie avec Contumace (Buchet-Chastel, 2018) et sur des questions générales d’écriture.
Mot-clés: roman, écrivain, français, Jean-Pierre Brouillaud, entretien
Study on the Physicochemical Characteristics and Dust Suppression Performance of New Type Chemical Dust Suppressant for Copper Mine Pavement
Authors: Huang Zhian , Huang Yang , Yang Zhijun , Zhang Jun , Zhang Yinghua , Gao Yukun , Shao Zhenlu , Zhang Linghua 
Published: March 2021

Abstract
Mine road dust is an important source of dust in mine operations. The dust produced on the road surface is a great hazard to the workers. Aiming at the road dust of an open-pit mine, this paper conducts physical and chemical analysis of a dust suppressant prepared by using sodium polyacrylate as a binder, sodium carbonate as a moisture absorbent, polyethylene glycol as a water-retaining agent, and alkyl glycoside as a surfactant. Characterization of characteristics and dust suppression performance. The results show that the dust suppressant has a pH of 11.03, a viscosity of 18.5 mPa·s, and a surface tension of 28.1 mN/m. The content of heavy metal ions contained is less than the maximum concentration defined by the national standard. Under the same temperature condition, the greater the humidity, the stronger the hygroscopicity, especially when the humidity is 30%, where the better hygroscopic effect than water is obvious. The dust suppressant also has good anti-evaporation properties and it keeps at 4–5% moisture content after 10 days at a normal temperature. Compared with water, the dust suppressant has better resistance to wind erosion and compression. Under the same conditions, the loss rate of water is 2 times that of the dust suppressant and the pressure of the dust suppressant sample is about 3 times that of water. The dust suppressant has a much higher dust removal efficiency for all dust and respirable dust than water under the same conditions. Finally, the test results and mechanism of the dust suppression effect of the dust suppressant are described and analyzed, which shows that the dust suppressant studied in this paper has good performance and is suitable for road dust prevention.
Green Standard Model Using Machine Learning: Identifying Threats and Opportunities Facing the Implementation of Green Building in Iran
Authors: Rajabi Mohamad , Sardroud Javad Majrouhi , Kheyroddin Ali 
Published: March 2021

Abstract
Residential buildings consume a major portion of energy resources and hence are seriously involved in environmental pollution. In Iran, the consumption of fossil fuels is on the rise, to the extent that it has grown by more than 400% from 1990 to 2018. One of the fundamental solutions for reducing fossil fuel consumption and creating a healthy environment inside and outside buildings is the implementation and development of green buildings. This study seeks to examine the obstacles and opportunities facing green building and proposes a localized green standard befitting the conditions of Iran with the aim of contributing to the development of green buildings. To this end, the requisite parameters were identified using the opinions of experts and Delphi method, and the opinions of 81 building experts including the employer, consultant and contractor were obtained using a three-part questionnaire. Based on the results obtained using the machine learning method, the score of the local green building in a total of five dimensions, namely site, water, energy, materials and quality of indoor environment was calculated to be 77.2, while the energy dimension was determined to be the most important green standard dimension with a significance coefficient of 0.548. In the ranking analysis of all parameters using Friedman test, the parameters of energy consumption management, use of renewable energy and thermal zoning attained the highest scores among other factors. Furthermore, lack of awareness on green buildings (77%) and high potential for renewable energy production (81%) were respectively identified as the biggest obstacle and opportunity facing the implementation of green buildings in Iran.
Research on the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking
Authors: Shu Xinyao , Zhang Yunwu , Wang Yujia , Wu Jing , Chen Xingyu , Xu Ruitong , Liu Xingting , Luo Jingsong , Deng Tingting 
Published: March 2021

Abstract
Background: To predict the mechanism of Huaijiao Diyu Decoction in the treatment of colorectal cancer. Methods: The active components and related targets of 7 kinds of Chinese medicinal materials were collected from the database of Chinese medicinal materials. CRC related targets are obtained from the Genes card database. cross targets of disease and drug targets were input into the STRING database to construct protein-protein interaction networks.GO enrichment analysis and KEGG enrichment analysis using clusterProfiler packets in the language, Finally, the interaction between core components and core targets is discussed by molecular docking.Result: TCMSP database prompts, There are 34 active compounds mapping 114 targets in Sophora japonica decoction; G enecards database prompts, A total of 858 targets are closely related to CRC, The two data sets map each other to obtain 114 intersection targets. Core components of Sophora flavescens decoction in treating CRC may be quercetin, kaempferol, luteolin, The core therapeutic targets may be PTGS2、PTGS1、HSP90AA1 and AR, CRC related pathways involve multiple molecular functions such as cell proliferation, apoptosis, cell signal transduction, metabolism, endocrine, tumor immunity, transcription and cell metabolism. Molecular docking results show that the binding ability of PTGS1、PTGS2、AR to core components is strong, The Vina value (binding energy) of the interaction between PTGS1 protein and core components is the best, -7.9kcal/mol . Conclusion: This study demonstrates the mechanism of multi-component, multi-target and multi-pathway action in the treatment of CRC, Can provide the idea for clarifying the specific mechanism of Huaijiao Diyu decoction in the treatment of CRC in the future.
Effects of Confounding Factors on Blood Pressure in Hypertensive Patients: A Cross Sectional Study
Authors: Ersoy Emrah , Ardic Cuneyt 
Published: March 2021

Abstract
Background Blood pressure is influenced by biopsychosocial factors such as physical, environmental, emotional, cognitive and behavioral in hypertensive patients. ObjectiveThe aim of this study is to investigate confounding factors in hypertensive patients who have poor blood pressure control.DesignThis study was designed as a cross-sectional study.ParticipantsOur sample was 407 patients with hypertension in Rize, a Northern city in the Black Sea Region of Turkey. In study group, there were 207 hypertensive patients who had admission to emergency department due to high blood pressure. In control group, there were 200 hypertensive patients visiting family physician,who defined themselves as having regulated blood pressure over the past six months.Main MeasuresPatients completed the questionnaire including sociodemographic data, lifestyle behaviors, health risks and confounding factors via the face-to-face interview method. Key ResultsOf the hypertensive patients, 81.2% (n=168) of the study group and 34.0% (n=68) of the control group had confounding factors. There was a significant difference between the hypertensive patients of study and control group in terms of their confounding factors (p<0.001). When we asked the patients of study group questions to reveal their confounding factors, 21.3% (n=44) stated ‘anger’, 12.6% (n=26) ‘sadness’, 11.1% (n=23) ‘anxiety’, 10.6% (n=22) ‘depressed’, 9.2% (n=19) ‘unhealthy diet’, 7.2% (n=15) ‘fatigue and poor sleep quality’, and 3.9% (n=8) ‘irregular medication’. Mean systolic and diastolic blood pressure were significantly higher in hypertensive patients having confounding factors than those without confounding factors (p=0.001, p=0.001, respectively). Mean systolic blood pressure of hypertensives who stated their confounding factor as ‘anger’ was significantly higher than those the remaining groups (p<0.001).ConclusionsThis study has shown that confounding factors impair blood pressure control in patients with hypertension. Confounding factors should be kept in mind and revealed in case of poor blood pressure control in hypertensive patients.
Stomach secretes estrogen in response to blood triglyceride levels in males
Authors: Kanai Yoshimitsu , Ito Takao , Yamamoto Yuta , Yamagishi Naoko 
Published: March 2021

Abstract
The central nervous system receives body energy information and controls feeding behavior and lipogenesis1. Ghrelin, insulin, leptin and vagal afferents transmit the status of fasting, blood glucose, body fat, and food intake, respectively2-5. Estrogen, which is secreted from adipocytes and gastric parietal cells and from the ovaries in females, also acts upon the central nervous system and liver to inhibit feeding behavior and lipogenesis6-9. How blood triglyceride levels are monitored and how estrogen levels are regulated from the perspective of the lipid homeostasis is not well understood. Using male rats, we show that gastric parietal cells secrete estrogen in response to blood triglyceride levels. Parietal cells predominantly use fatty acid as an energy source. When male rats are administered olive oil or glucose, blood estrogen levels increase as the blood triglyceride, but not glucose, levels rise. Estrogen levels in stomach tissues increase as the blood triglyceride levels rise, and blood triglyceride level-dependent increases of blood estrogen levels are cancelled in gastrectomized rats. We therefore propose that in males, parietal cells in the stomach act as a sensor for the blood triglyceride levels and can secrete estrogen to inhibit the hepatic lipogenesis and feeding behavior when blood triglyceride levels are high.
WITHDRAWN: Composite Immersion and Invariance Based Adaptive Attitude Control of Asteroid-Orbiting Spacecraft in Elliptic Orbit
Authors: Lee Keum W , Singh Sahjendra N 
Published: March 2021

Abstract
This paper proposes a new composite noncertainty-equivalence adaptive (CNCEA) control system for the attitude (roll, pitch, and yaw angle) control of a spacecraft in an orbit around a uniformly rotating asteroid based on the immersion and invariance (I&I) theory. For the design, it is assumed that the asteroid's gravitational parameters and the spacecraft's inertia matrix are not known. In contrast to certainty-equivalence adaptive (CEA) or noncertainty-equivalence adaptive (NCEA) systems, the CNCEA attitude control system's composite identifier uses the attitude angle tracking error, a nonlinear state-dependent vector function, and model prediction error for parameter estimation. The Lyapunov analysis shows that in the closed-loop system, the Euler angles asymptotically track the reference attitude trajectories. Interestingly, there exist two parameter error-dependent attractive manifolds, to which the closed-loop system's trajectories converge. Moreover, the composite identifier using two types of error signals provides stronger stability properties in the closed-loop system. Simulation results are presented for the attitude control of a spacecraft orbiting in the vicinity of the asteroid 433 Eros. These results show precise nadir pointing attitude regulation, despite uncertainties in the system.
COVID-19 in a Multiple Myeloma Patient: Cellular and Humoral Immunity Against SARS-CoV-2 in a Short- and Long-term View
Authors: von Metzler Ivana , Campe Julia , Huenecke Sabine , Raab Marc , Goldschmidt Hartmut , Schubert Ralf , Rabenau Holger , Ciesek Sandra , Serve Hubert , Ullrich Evelyn 
Published: March 2021

Abstract
Multiple myeloma patients are often treated with immunomodulatory drugs, proteasome inhibitors or monoclonal antibodies until disease progression. Chronic therapy in combination with the underlying disease frequently results in severe humoral and cellular immunodeficiency, which often manifests in recurrent infections. Here we report on the clinical management and immunological data of one multiple myeloma patient diagnosed with COVID-19. Despite severe hypogammaglobulinemia, deteriorated T cell counts and neutropenia, the patient unexpectedly combated COVID-19 by balanced response of innate immunity, strong CD8+ and CD4+ T cell activation and differentiation, development of specific T-cell memory subsets, as well as development of anti-SARS-CoV-2 type IgA and IgG antibodies. Even 6 months after re-introduction of lenalidomide maintenance therapy, specific T cell response and antibody levels remained detectable, indicating persisting immunity against SARS-CoV-2. We conclude that in MM patients who tested positive for SARS-CoV-2 and were receiving active MM treatment, immune response assessment could be a useful tool to help guide decision-making regarding the continuation of anti-tumor therapy and supportive therapy.
Time Since Rewetting Defines Vegetation Composition and Carbon Dioxide Fluxes on Former Milled Peatlands - Comparison With Undisturbed Bogs
Authors: Purre Anna-Helena , Ilomets Mati 
Published: March 2021

Abstract
Rewetting is the most common restoration approach for milled peatlands in Europe, with the aim of creating suitable conditions for the development of peatland specific plant cover and carbon accumulation. Therefore, it is important to determine if time since rewetting is pivotal for milled peatlands to become functionally and structurally similar to their undisturbed counterparts. We investigate the temporal succession in rewetted peatlands in Estonia by a chronosequence of 4, 15, and 35 years before the measurements. Plant functional type (PFT) cover and biomass, bryophyte production and CO2 fluxes were measured on two milled peatlands, as well as undisturbed bogs adjacent to milled peatlands. Differences in vegetation composition and CO2 fluxes between the sites were greater for rewetted than undisturbed sites. The most recently rewetted site was mainly covered in bare peat and Eriophorum vaginatum and was a CO2 source. On the rewetted site of 15 years, Sphagnum was present in addition to ombrotrophic sedges, and in the rewetted site of 35 years, lawn-hollow microtopography is starting to develop with various PFTs. Both of these sites were CO2 sinks. Lawn Sphagnum was abundant on the two older rewetted sites, and was connected with CO2 sink functioning in the rewetted sites. Still, hummock Sphagnum species, which were present in undisturbed bogs, were absent from all of the rewetted sites. With time, CO2 fluxes, microtopography and vegetation develop after rewetting in the direction of undisturbed bogs, while vegetation composition still differs from the reference sites even 35 years after rewetting.
Comparison of Success Rate of Extubation Between Spontaneous Breathing Trial with Pressure Support Ventilation and T-piece in Patients with Expiratory Flow Limitation
Authors: Kluanwan Yanisa , Kongpolprom Napplika 
Published: March 2021

Abstract
Background: Expiratory flow limitation (EFL) is an inability to exceed a certain flow regardless of the pressure exerted, which appears in 60% of patients with extubation failure. However, an appropriate weaning method for the patients with EFL remains unknown.

Objectives: We aimed to evaluate an effect of different techniques of spontaneous breathing trials (SBT) on a success rate of extubation in the patients with EFL.

Methods: We conducted a non-inferiority randomized controlled trial comparing between 30-minute pressure support ventilation (PSV) and 30-minute T-piece in ventilated patients with EFL who got ready to wean. The primary outcome was successful extubation during a 72-hour post-extubation period. Secondary outcomes were a reintubation rate within 7 days, time to reintubation, and a SBT success rate.

Results: A total of 99 ventilated patients with EFL consisting of male (50.5%) with the median age of 70 [23] years were recruited. The most common cause of acute respiratory failure was intrapulmonary cause (68.7%). The eligible patients were randomized into 2 groups with a ratio of 1:1. The success rate of extubation during the 72-hour period in the PSV group was non-inferior to the T-piece group: 82% and 81.63%, respectively (95%CI -0.148 to 0.156, p=0.0475). There was also non-inferiority in the reintubation rate within 7 days (22.9% in the PSV group VS 15.2% in the T-piece group; 95%CI -0.081 to 0.235, p=0.005) and the SBT success rate (96% in the PSV group VS 93.9% in the T-piece group; 95%CI -0.065 to 0.108, p<0.001). There was no significant difference in the median time to reintubation between these 2 groups (55 [95.5] hours in PSV VS 25.33 [48] hours in the T-piece group, p=0.683).

Conclusions: Among patients with EFL, the 30-minute SBT with PSV was non-inferior to the T-piece SBT in terms of the successful extubation during the 72-hour period, successful SBT, and reintubation rate within 7 days. This was the first study demonstrating that the different techniques of SBT did not affect the weaning outcomes in the patients with EFL.
Estimating Prevalence of Human Traits Among Populations From Polygenic Risk Scores
Authors: Graham Britney , Plotkin Brian , Muglia Louis , Moore Jason , Williams Scott 
Published: March 2021

Abstract
The genetic basis of phenotypic variation across populations has not been well explained for most traits. Several factors may cause disparities, from variation in environments to divergent population genetic structure. We hypothesized that a population level polygenic risk score (PRS) can explain phenotypic variation among geographic populations based solely on risk allele frequencies. We applied a population specific PRS (psPRS) to 26 populations from the 1000 Genomes to four phenotypes: lactase persistence (LP), melanoma, multiple sclerosis (MS) and height. Our models assumed additive genetic architecture among the polymorphisms in the psPRS, as is convention. Linear psPRSs explained a significant proportion of trait variance ranging from 0.32 for height in men to 0.88 for melanoma. The best models for LP and height were linear, while those for melanoma and MS were nonlinear. As not all variants in a PRS may confer similar, or even any, risk among diverse populations, we also filtered out SNPs to assess whether variance explained was improved using psPRSs with fewer SNPs. Variance explained usually improved with fewer SNPs in the psPRS and were as high as 0.99 for height in men using only 548 of the initial 4208 SNPs. That reducing SNPs improves psPRS performance may indicate that missing heritability is partially due to complex architecture that does not mandate additivity, undiscovered variants, or spurious associations in the databases. We demonstrated that PRS based-analyses can be used across diverse populations and phenotypes for population prediction and that these comparisons can identify the universal risk variants.
Clinical pharmacist interventions during clinical rounding in a psychiatric hospital: Positive evidence for pharmacists in interdisciplinary rounding at psychiatric hospital
Authors: Stuhec Matej , Tement Valentina 
Published: March 2021

Abstract
Clinical pharmacists have not yet become an integral part of interdisciplinary ward rounds in most psychiatric hospitals across the European Union. This retrospective study examined the impact of the recommendations from a clinical pharmacist during hospital rounds as part of an interdisciplinary medical team in a psychiatric hospital. This retrospective observational pre-post study included all patients in a Slovenian psychiatric hospital who were hospitalized in 2019–2020. The clinical pharmacist made 315 recommendations for a total of 244 participants (average age M = 59.4, median = 56). Psychiatrists accepted 295 (93.7%) of the recommendations. After the recommendations, the number of expressed DRPs decreased in 166 interventions (93.8%) and the number of potential DRPs in 129 interventions (93.8%). Three months after discharge, 222 accepted recommendations were continued (70.5%). The most common recommendations were related to antipsychotics (19.4%, N = 61) followed by antidepressants (16.8%, N = 53). Including a clinical pharmacist in the interdisciplinary ward rounds in a psychiatric hospital reduced the number of expressed and potential DRPs with a very high recommendation acceptance rate. These results are the first in the European Union to show the benefits of including a clinical pharmacist in ward rounding.