bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potassium carbonate-based ternary transition temperature mixture (deep eutectic analogues) for CO2 absorption: Characterizations and DFT analysis
Authors: Ghaedi Hosein , Kalhor Payam , Zhao Ming , Clough Peter T. , Anthony Edward J. , Fennell Paul S. 
Published: November 2021

AbstractIs it possible to improve CO2 solubility in potassium carbonate (K2CO3)-based transition temperature mixtures (TTMs)? To assess this possibility, a ternary transition-temperature mixture (TTTM) was prepared by using a hindered amine, 2-amino-2-methyl-1,3-propanediol (AMPD). Fourier transform infrared spectroscopy (FT-IR) was employed to detect the functional groups including hydroxyl, amine, carbonate ion, and aliphatic functional groups in the prepared solvents. From thermogravimetric analysis (TGA), it was found that the addition of AMPD to the binary mixture can increase the thermal stability of TTTM. The viscosity findings showed that TTTM has a higher viscosity than TTM while their difference was decreased by increasing temperature. In addition, Eyring’s absolute rate theory was used to compute the activation parameters (∆G*, ∆H*, and ∆S*). The CO2 solubility in liquids was measured at a temperature of 303.15 K and pressures up to 1.8 MPa. The results disclosed that the CO2 solubility of TTTM was improved by the addition of AMPD. At the pressure of about 1.8 MPa, the CO2 mole fractions of TTM and TTTM were 0.1697 and 0.2022, respectively. To confirm the experimental data, density functional theory (DFT) was employed. From the DFT analysis, it was found that the TTTM + CO2 system has higher interaction energy (|∆E|) than the TTM + CO2 system indicating the higher CO2 affinity of the former system. This study might help scientists to better understand and to improve CO2 solubility in these types of solvents by choosing a suitable amine as HBD and finding the best combination of HBA and HBD.
Immunotherapy of HBV-related advanced hepatocellular carcinoma with short-term HBV-specific TCR expressed T cells: results of dose escalation, phase I trial
Authors: Meng Fanping , Zhao Jinfang , Tan Anthony Tanoto , Hu Wei , Wang Si-Yu , Jin Jiehua , Wu Juan , Li Yuanyuan , Shi Lei , Fu Jun-Liang , Yu Shuangjie , Shen Yingjuan , Liu Limin , Luan Junqing , Shi Ming , Xie Yunbo , Zhou Chun-Bao , Wong Regina Wanju , Lu-En Wai , Koh Sarene , Bertoletti Antonio , Wang Tingting , Zhang Ji-Yuan , Wang Fu-Sheng 
Published: November 2021

Abstract
Background & aims
Immunotherapy with hepatitis B virus (HBV)-specific TCR redirected T (HBV-TCR-T) cells in HBV-related hepatocellular carcinoma (HBV-HCC) patients after liver transplantation was reported to be safe and had potential therapeutic efficacy. We aim to investigate the safety of HBV-TCR-T-cell immunotherapy in advanced HBV-HCC patients who had not met the criteria for liver transplantation.

Methods
We enrolled eight patients with advanced HBV-HCC and adoptively transferred short-lived autologous T cells expressing HBV-specific TCR to perform an open-label, phase 1 dose-escalation study (NCT03899415). The primary endpoint was to evaluate the safety of HBV-TCR-T-cell therapy according to National Cancer Institute Common Terminology Criteria for Adverse Events (version 4.03) during the dose-escalation process. The secondary endpoint was to assess the efficacy of HBV-TCR-T-cell therapy by evaluating the anti-tumor responses using RECIST criteria (version 1.1) and the overall survival.

Results
Adverse events were observed in two participants among the 8 patients enrolled. Only one patient experienced a Grade 3 liver-related adverse event after receiving a dose of 1 × 105 HBV-TCR-T cells/kg, then normalized without interventions with immunosuppressive agents. Among the patients, one achieved a partial response lasting for 27.7 months. Importantly, most of the patients exhibited a reduction or stabilization of circulating HBsAg and HBV DNA levels after HBV-TCR-T-cell infusion, indicating the on-target effects.

Conclusions
The adoptive transfer of HBV-TCR-T cells into advanced HBV-HCC patients were generally safe and well-tolerated. Observations of clinical efficacy support the continued development and eventual application of this treatment strategy in patients with advanced HBV-related HCC.

Clinical trials registration
This study was registered at ClinicalTrials.gov (NCT03899415).
Right Heart Morphology of Candidate Patients for Transcatheter Tricuspid Valve Interventions
Authors: Khalique Omar K. , Jelnin Vladimir , Hueske Andreas , Lawlor Mathew , Leon Martin B. , Kodali Susheel K. , Akkoc Deniz , Pettway Eriq , Hahn Rebecca T. , Hamid Nadira B. , George Isaac , Patel Amisha , Ng Vivian , Vahl Torsten P. , Nazif Tamim M. , Siefert Andrew W. 
Published: December 2021

Abstract
Purpose
This study quantitatively evaluated the phasic right heart morphology of candidate patients for a transcatheter tricuspid valve intervention (N=32) and of subjects with trace to no tricuspid regurgitation (N = 14).

Methods
Cardiac computed tomography angiography (CCTA) and transthoracic/transesophageal echocardiography (TTE/TEE) images were analyzed using dedicated research and clinical software. Using CCTA, the phasic right atrial and ventricular volumes, annulus dimensions, annulus-to-right coronary artery (RCA) distances, circumferential topography of the annular tissue shelf, vena cava dimensions (inferior and superior), vena cava positions, axis angles, and annular excursions were quantified. Using TTE/TEE, leaflet geometry, regurgitation, hemodynamics, and heart function were quantified. Measurements within and between groups were quantitatively compared with regression analyses to explore relationships between right heart features.

Results
The phasic position and orientation of the vena cava and the circumferential topography of the annular tissue shelf were quantitatively presented for the first time. The candidate patient group exhibited greater chamber dimensions, enlarged vena cava, distended vena cava positions, positional shallowing of the annular tissue shelf, geometric annular distortion, leaflet distention, moderate or greater regurgitation, and impaired ventricular function. Atrial volume correlated strongly with directional vena cava positions as well as with annular dimensions. Annulus-to-RCA distances and annular excursions were comparable between groups.

Conclusions
This study provides new and further insight to the right heart morphology and functional characteristics of candidate patients for a transcatheter tricuspid valve intervention. These data provide a platform from which these patients can continue to be better understood for further improving transcatheter system design and use.
Degrading permafrost river catchments and their impact on Arctic Ocean nearshore processes
Authors: Mann Paul J. , Strauss Jens , Palmtag Juri , Dowdy Kelsey , Ogneva Olga , Fuchs Matthias , Bedington Michael , Torres Ricardo , Polimene Luca , Overduin Paul , Mollenhauer Gesine , Grosse Guido , Rachold Volker , Sobczak William V. , Spencer Robert G. M. , Juhls Bennet 
Published: November 2021

AbstractArctic warming is causing ancient perennially frozen ground (permafrost) to thaw, resulting in ground collapse, and reshaping of landscapes. This threatens Arctic peoples' infrastructure, cultural sites, and land-based natural resources. Terrestrial permafrost thaw and ongoing intensification of hydrological cycles also enhance the amount and alter the type of organic carbon (OC) delivered from land to Arctic nearshore environments. These changes may affect coastal processes, food web dynamics and marine resources on which many traditional ways of life rely. Here, we examine how future projected increases in runoff and permafrost thaw from two permafrost-dominated Siberian watersheds—the Kolyma and Lena, may alter carbon turnover rates and OC distributions through river networks. We demonstrate that the unique composition of terrestrial permafrost-derived OC can cause significant increases to aquatic carbon degradation rates (20 to 60% faster rates with 1% permafrost OC). We compile results on aquatic OC degradation and examine how strengthening Arctic hydrological cycles may increase the connectivity between terrestrial landscapes and receiving nearshore ecosystems, with potential ramifications for coastal carbon budgets and ecosystem structure. To address the future challenges Arctic coastal communities will face, we argue that it will become essential to consider how nearshore ecosystems will respond to changing coastal inputs and identify how these may affect the resiliency and availability of essential food resources.
Exploring Forest Sector Research Subjects and Trends from 2000 to 2019 Using Topic Modeling
Authors: Nummelin T. , Hänninen R. , Kniivilä M. 
Published: November 2021

AbstractPurpose of ReviewThis review aims to discover the most common topics and trends in international scientific forest sector research between January 2000 and December 2019 and to test the suitability of a quantitative topic-modeling method to extract topics from the data. The results will be helpful for both researchers and policy decision-makers in identifying emerging research topics and possible research gaps. The analysis framework covers the complete forest wood chain (FWC) with PESTE factors. PESTE is applied to analyze political, economic, social, technological, and ecological/environmental factors affecting the FWC.Recent findingsIn the last two decades, forests and the forest sector have been impacted by several global changes, policies, and megatrends. Previous systematic syntheses of forest sector research reveal that economic, policy, and social research have remained underrepresented in the forest sector literature. Research areas related to forest ecology and climate change have been increasing. More recently, growth has also been detected in social aspects especially related to the increasing literature on forest ecosystem services.ResultsA total of 160 topics were extracted from 14,470 abstracts of 15 leading international peer-reviewed forest science journals. The ecological topics of forest resources and technological topics of industry and products were by far the two largest subject areas. Ecological topics increased, while technological topics slightly decreased, during the period between 2000 and 2019. A clear decline in the share of topics concerning end-product markets was detected. Indeed, changes in end markets drive changes in the entire forest wood chain. To support the goal of a transition from a fossil-based economy to a bioeconomy, it will be important to increase academic research on policy impacts, as well as social and ecological sustainability issues to cover all the stages of the FWC more evenly. The topic-modeling method was a useful tool in data mining, but human intelligence is needed to interpret and classify the topics extracted by this approach.
HPV and Pap testing among white, black, and hispanic women: results from a survey study
Authors: Ventura Ilana M. , Zhong Selena , Bilgen Ipek , Dutwin David , Delgado Jane L. 
Published: November 2021

AbstractWhile the Pap test, HPV vaccine, and HPV test are important tools to promote cervical health, the American Cancer Society (ACS) recently updated its cervical cancer prevention recommendations to give primacy to HPV testing for cervical cancer screening. We investigate how women’s health providers view these changes, and the extent to which they have reached American women. To do so, we present results from a novel two-survey study of women’s health providers (N = 558) and White, Black, and Hispanic women (N = 1900). We find that a minority of providers report that the HPV test alone is adequate for cervical cancer screening (18%, CI = 14%, 21%) while 96% (CI = 94%, 97%) indicated that women should regularly have both Pap and HPV screenings. Black (88% CI = 86%, 91%) and Hispanic (87% CI = 84%, 89%) women report lower rates of Pap tests compared to White women (94%, CI = 92%, 96%). Only 35% (CI = 33%, 37%) of women report having had an HPV test, and these levels were similar across groups. White (29%, CI = 25%, 33%) and Hispanic women (26% CI = 23%, 29%) report statistically similar levels of provider recommendation for joint Pap-HPV testing, while Black women report statistically lower rates (22%, CI = 18%, 25%). These patterns hold after controlling for several important socio-demographic variables in logistic regression models. The continued lower rates of Pap tests among Black and Hispanic women, combined with low rates of HPV testing is likely to hinder the ability to reduce cervical cancer incidence and mortality, particularly for Hispanic and Black women.
Discontinuing MRSA and VRE contact precautions: Defining hospital characteristics and infection prevention practices predicting safe de-escalation
Authors: Martin Elise M. , Colaianne Bonnie , Bridge Christine , Bilderback Andrew , Tanner Colleen , Wagester Suzanne , Yassin Mohamed , Pontzer Raymond , Snyder Graham M. 
Published: December 2021

AbstractObjective:To define conditions in which contact precautions can be safely discontinued for methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE).Design:Interrupted time series.Setting:15 acute-care hospitals.Participants:Inpatients.Intervention:Contact precautions for endemic MRSA and VRE were discontinued in 12 intervention hospitals and continued at 3 nonintervention hospitals. Rates of MRSA and VRE healthcare-associated infections (HAIs) were collected for 12 months before and after. Trends in HAI rates were analyzed using Poisson regression. To predict conditions when contact precautions may be safely discontinued, selected baseline hospital characteristics and infection prevention practices were correlated with HAI rate changes, stratified by hospital.Results:Aggregated HAI rates from intervention hospitals before and after discontinuation of contact precautions were 0.14 and 0.15 MRSA HAI per 1,000 patient days (P = .74), 0.05 and 0.05 VRE HAI per 1,000 patient days (P = .96), and 0.04 and 0.04 MRSA laboratory-identified (LabID) events per 100 admissions (P = .57). No statistically significant rate changes occurred between intervention and non-intervention hospitals. All successful hospitals had low baseline MRSA and VRE HAI rates and high hand hygiene adherence. We observed no correlations between rate changes after discontinuation and the assessed hospital characteristics and infection prevention factors, but the rate improved with higher proportion of semiprivate rooms (P = .04).Conclusions:Discontinuing contact precautions for MRSA/VRE did not result in increased HAI rates, suggesting that contact precautions can be safely removed from diverse hospitals, including community hospitals and those with lower proportions of private rooms. Good hand hygiene and low baseline HAI rates may be conditions permissive of safe removal of contact precautions.
Petrogenesis of contrasting magmatic suites in the Abu Kharif area, Northern Eastern Desert, Egypt: implications for Pan-African crustal evolution and tungsten mineralization
Authors: Abdel Wanees Nora G , El-Sayed Mohamed M , Khalil Khalil I , Khamis Hossam A 
Published: November 2021

AbstractThe Abu Kharif area in the Northern Eastern Desert consists of contrasting granitic magma suites: a Cryogenian granodiorite suite (850–635 Ma), an Ediacaran monzogranite suite (635–541 Ma) and a Cambrian alkali riebeckite granite suite (541–485 Ma). Tungsten mineralization occurs within W-bearing quartz veins and a disseminated type confined to the monzogranite.Whole-rock geochemical data classify the granodiorite as a late-orogenic I-type with calc-alkaline affinity, while the monzogranite and alkali riebeckite granite represent respectively a post-orogenic highly fractionated I-type with calc-alkaline affinity and an anorogenic A1-subtype with alkaline affinity. Geochemical modelling indicates that the three intrusions represent separate magmatic pulses where the granodiorite was generated by ∼75 % batch partial melting of an amphibolitic source followed by fractional crystallization of hornblende, biotite, apatite and titanite. The monzogranite was formed by 62 % batch partial melting of the normal ‘non-metasomatized’ Pan-African crust of calc-alkaline granite composition followed by fractional crystallization of plagioclase, biotite, K-feldspar, magnetite, ilmenite, with minor apatite and titanite. The alkali riebeckite granite was generated by 65 % batch partial melting of metasomatized Pan-African granite source followed by fractional crystallization of plagioclase, K-feldspar, amphibole and biotite with minor magnetite, apatite and titanite. In general, the parent magmas of the three intrusions were originally enriched in W, but with different concentrations. This W-enrichment would be caused by magmatic-related hydrothermal volatile-rich fluids and concentrated within the monzogranite.
Predicting intention to hunt protected wildlife: a case study of Bewick's swan in the European Russian Arctic
Authors: Newth Julia L. , McDonald Robbie A. , Wood Kevin A. , Rees Eileen C. , Semenov Igor , Chistyakov Anton , Mikhaylova Galina , Bearhop Stuart , Cromie Ruth L. , Belousova Anna , Glazov Petr , Nuno Ana 
Published: November 2021

AbstractIllegal killing of wildlife is a major conservation issue that, to be addressed effectively, requires insight into the drivers of human behaviour. Here we adapt an established socio-psychological model, the theory of planned behaviour, to explore reasons for hunting the Endangered Bewick's swan Cygnus columbianus bewickii in the European Russian Arctic, using responses from hunters to a questionnaire survey. Wider ecological, legal, recreational and economic motivations were also explored. Of 236 hunters who participated overall, 14% harboured intentions to hunt Bewick's swan. Behavioural intention was predicted by all components of the theory of planned behaviour, specifically: hunters' attitude towards the behaviour, perceived behavioural control (i.e. perceived capability of being able to perform the behaviour) and their subjective norms (perception of social expectations). The inclusion of attitude towards protective laws and descriptive norm (perception of whether other people perform the behaviour) increased the model's predictive power. Understanding attitudes towards protective laws can help guide the design of conservation measures that reduce non-compliance. We conclude that conservation interventions should target the socio-psychological conditions that influence hunters' attitudes, social norms and perceived behavioural control. These may include activities that build trust, encourage support for conservation, generate social pressure against poaching, use motivations to prompt change and strengthen peoples' confidence to act. This approach could be applied to inform the effective design, prioritization and targeting of interventions that improve compliance and reduce the illegal killing of wildlife.
Seismic Imaging of a Magma Chamber and Melt Recharge of the Dormant Datong Volcanoes
Authors: He Lipeng , Guo Zhen , Chen Yongshun John , Huang Qinghua , Yang Yingjie 
Published: November 2021

AbstractThe Datong volcanoes erupted episodically from ca. 0.74 to ca 0.10 Ma with the last eruption at ca. 100 ka, and ever since has remained dormant. It remains elusive whether the Datong volcanoes are being recharged and would become active again in the near future. Here, we image the crustal structures beneath the Datong volcanoes using local earthquake data recorded at a newly deployed dense Datong Nodal Array. The high‐resolution 3‐D model reveals, for the first time, the geometry and melt fraction of a shallow crustal magma chamber at the depths of 10–20 km beneath the Datong volcanoes. Here, we suggest a magmatic system beneath the Datong volcanoes that could transport basaltic melt from the uppermost mantle to the shallow crustal magma chamber beneath the Datong volcanoes. Further, the melt‐poor crustal magma chamber (melt fraction of 5%–10%) can explain why the Datong volcanoes are inactive at present, and future eruptions can be expected if melt recharge from a mantle source is sustained.
The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats
Authors: Gan Hui , Zhang Li , Chen Hui , Xiao Han , Wang Lu , Zhai Xuan , Jiang Ning , Liang Ping , Zheng Shuyue , Zhao Jing 
Published: November 2021

AbstractThe NLRC4 inflammasome, a member of the nucleotide-binding and oligomerization domain-like receptor (NLR) family, amplifies inflammation by facilitating the processing of caspase-1, interleukin (IL)–1β, and IL-18. We explored whether NLRC4 knockdown alleviated inflammatory injury following intracerebral hemorrhage (ICH). Furthermore, we investigated whether NLRC4 inflammasome activation can be adjusted by the regulator of G protein signaling 2/leucine-rich repeat kinase-2 pathway. Fifty microliters of arterial blood was drawn and injected into the basal ganglion to simulate the ICH model. NLRC4 small interfering RNAs (siRNAs) were utilized to knockdown NLRC4. An LRRK2 inhibitor (GNE7915) was injected into the abdominal cavity. Short hairpin (sh) RNA lentiviruses and lentiviruses containing RGS2 were designed and applied to knockdown and promote RGS2 expression. Neurological functions, brain edema, Western blot, enzyme-linked immunosorbent, hematoxylin and eosin staining, Nissl staining, immunoprecipitation, immunofluorescence assay and Evans blue dye extravasation and autofluorescence assay were evaluated. It was shown that the NLRC4 inflammasome was activated following ICH injury. NLRC4 knockdown extenuated neuronal death, damage to the blood-brain barrier, brain edema and neurological deficiency 3 days after ICH. NLRC4 knockdown reduced myeloperoxidase (MPO) cells as well as tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β and IL-18 following ICH. GNE7915 reduced pNLRC4 and NLRC4 inflammasome activation. RGS2 suppressed the interaction of LRRK2 and NLRC4 and NLRC4 inflammasome activation by regulating pLRRK2. Our study demonstrated that the NLRC4 inflammasome may aggravate the inflammatory injury induced by ICH and that RGS2/LRRK2 may relieve inflammatory injury by restraining NLRC4 inflammasome activation.
Natural killer cell-derived exosomal miR-1249-3p attenuates insulin resistance and inflammation in mouse models of type 2 diabetes
Authors: Wang Ying , Li Mengwei , Chen Lin , Bian Huan , Chen Xiangying , Zheng Huilin , Yang Peiwei , Chen Quan , Xu Hanmei 
Published: November 2021

AbstractNatural killer (NK) cells have been suggested to be associated with type 2 diabetes by regulating systemic inflammation. However, the mechanism by which NK cells regulate insulin sensitivity remains unknown. This study shows that NK-derived exosomes from lean mice attenuate obesity-induced insulin resistance and inflammation in mice of type 2 diabetes. Moreover, lean NK-derived exosomes enhance insulin sensitivity and relieve inflammation in adipocytes and hepatocytes. MiR-1249-3p, which is significantly upregulated in lean NK-derived exosomes, can be transferred from NK cells to adipocytes and hepatocytes via exosomes. NK-derived exosomal miR-1249-3p dramatically induces cellular insulin sensitivity and relieves inflammation. Mechanistically, exosomal miR-1249-3p directly targets SKOR1 to regulate the formation of ternary complex SMAD6/MYD88/SMURF1, which mediates glucose homeostasis by suppressing the TLR4/NF-κB signaling pathway. This study reveals an emerging role for NK-derived exosomal miR-1249-3p in remission of insulin resistance, and provides a series of potential therapeutic targets in type 2 diabetes.