bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk score to stratify miscarriage risk levels in preconception women
Authors: Choo Xin Hui , Ku Chee Wai , Cheung Yin Bun , Godfrey Keith M. , Chong Yap-Seng , Shek Lynette Pei-Chi , Tan Kok Hian , Tan Thiam Chye , Nadarajah Sadhana , Yap Fabian Kok Peng , Colega Marjorelee T. , Chong Mary Foong-Fong , Chan Shiao-Yng , Loy See Ling , Chan Jerry Kok Yen 
Published: June 2021

AbstractSpontaneous miscarriage is one of the most common complications of pregnancy. Even though some risk factors are well documented, there is a paucity of risk scoring tools during preconception. In the S-PRESTO cohort study, Asian women attempting to conceive, aged 18-45 years, were recruited. Multivariable logistic regression model coefficients were used to determine risk estimates for age, ethnicity, history of pregnancy loss, body mass index, smoking status, alcohol intake and dietary supplement intake; from these we derived a risk score ranging from 0 to 17. Miscarriage before 16 weeks of gestation, determined clinically or via ultrasound. Among 465 included women, 59 had miscarriages and 406 had pregnancy ≥ 16 weeks of gestation. Higher rates of miscarriage were observed at higher risk scores (5.3% at score ≤ 3, 17.0% at score 4–6, 40.0% at score 7–8 and 46.2% at score ≥ 9). Women with scores ≤ 3 were defined as low-risk level (< 10% miscarriage); scores 4–6 as intermediate-risk level (10% to < 40% miscarriage); scores ≥ 7 as high-risk level (≥ 40% miscarriage). The risk score yielded an area under the receiver-operating-characteristic curve of 0.74 (95% confidence interval 0.67, 0.81; p < 0.001). This novel scoring tool allows women to self-evaluate their miscarriage risk level, which facilitates lifestyle changes to optimize modifiable risk factors in the preconception period and reduces risk of spontaneous miscarriage.
Data-driven analysis of facial thermal responses and multimodal physiological consistency among subjects
Authors: Sonkusare Saurabh , Breakspear Michael , Pang Tianji , Nguyen Vinh Thai , Frydman Sascha , Guo Christine Cong , Aburn Matthew J. 
Published: June 2021

AbstractFacial infra-red imaging (IRI) is a contact-free technique complimenting the traditional psychophysiological measures to characterize physiological profile. However, its full potential in affective research is arguably unmet due to the analytical challenges it poses. Here we acquired facial IRI data, facial expressions and traditional physiological recordings (heart rate and skin conductance) from healthy human subjects whilst they viewed a 20-min-long unedited emotional movie. We present a novel application of motion correction and the results of spatial independent component analysis of the thermal data. Three distinct spatial components are recovered associated with the nose, the cheeks and respiration. We first benchmark this methodology against a traditional nose-tip region-of-interest based technique showing an expected similarity of signals extracted by these methods. We then show significant correlation of all the physiological responses across subjects, including the thermal signals, suggesting common dynamic shifts in emotional state induced by the movie. In sum, this study introduces an innovative approach to analyse facial IRI data and highlights the potential of thermal imaging to robustly capture emotion-related changes induced by ecological stimuli.
Probing penile hemodynamics by using photoplethysmography as objective indicators for male erection quality and sexual function
Authors: Pong Yuan-Hung , Chang Yi-Kai , Hsu Ching-En , Chen Po-Cheng , Lu Yu-Chuan , Tsai Vincent F. S. , Chang Hong-Chiang , Lo Men-Tzung , Lin Chen 
Published: June 2021

AbstractErectile dysfunction (ED) is mostly due to the lack of blood flow into the penis. In the past 20 years, near-infrared spectroscopy (NIRS) was used in measuring the concentrations and temporal dynamics of different hemoglobin types. However, the dynamics of the light absorption (photoplethysmography; PPG) have not been applied to survey penile hemodynamics and erection quality. This paper compared the use of photoplethysmography (PPG) to study vascular ED with standard penile Doppler ultrasonography. Men diagnosed with vascular ED for at least 6 months and nominated for penile ultrasonography were included. PPG signals were collected during the ultrasound examination. All beat-to-beat PPG waveforms were aligned with the peak and averaged to one representative template waveform for feature analysis, including amplitude differences (APD) index, reflection time index (RTI), augmentation index (AI), and perfusion index (PI). An inverse correlation was found between end-erection amplitude and both erection hardness score (EHS) and resistive index (RI). APD index and EHS as well as the international index of erectile function-5 (IIEF) and RI were positively correlated. RTI and AI were inversely correlated to IIEF and RI. PI was positively correlated to RI. PPG may therefore be useful as a noninvasive, convenient, technique for sexual function evaluation.
Power and socialization in sibling interaction
Authors: Declercq Jana 
Published: June 2021

AbstractThis paper analyses socialization processes in the interaction between two Belgian, Dutch-speaking sisters, aged 10 and 8, more specifically with regard to power dynamics and establishing the roles of socialization target and agent. Socialization is collaborative, but usually entails some division of roles, which is intricately linked to power dynamics. Consequently, socialization efforts, and the socialization roles of target and agent, can be discarded or contested as part of these power dynamics. The analysis shows that socialization efforts between the sisters are often accepted, but also regularly contested and resisted. Moreover, the data indicates that roles and goals of some socialization efforts are so unclear that the boundaries between socialization efforts and interactional actions that aim to gain control become blurred. In conclusion, socialization must not only be considered in terms of its learning potential, but also as a power struggle with intricate and complex negotiation dynamics.
Grapevine red blotch virus (grapevine red blotch virus).
Authors: Fuchs Marc 
Published: June 2021

Abstract

The economic cost of GRBV is estimated to range from US $2,213/ha to $68,548/ha, depending on the initial infection rate and quality penalties for sub-standard fruits (Ricketts et al., 2017). In addition, there has been an unprecedented rate of vineyard removals in areas where the virus is widespread due to a substantially-reduced productive lifespan of GRBV-infected vineyard parcels.
Mycosphaerella gibsonii (needle blight of pine).
Authors: Minott Annika 
Published: June 2021

Abstract

Mycosphaerella gibsonii is a fungal pathogen causing needle blight, primarily in Pinus species. It causes lesions on needles, first affecting lower needles and then spreading to the upper crown. The disease eventually causes needle necrosis and needle cast, leading to defoliation, stunted growth and host plant death; it is a major obstacle to the production of pine seedlings. M. gibsonii occurs in the tropics and subtropics of South and Central America, the Caribbean, sub-saharan Africa, India, South East Asia and East Asia; the native range is uncertain. Although natural dispersal by wind and water occur locally, international spread is largely due to movement of infected nursery stock. Phytosanitary control measures such as avoiding the planting of infected plants, removal and destruction of all infected pines in nurseries and cleaning between annual production cycles in nurseries can help to reduce the spread of the pathogen. It is listed as an A1 quarantine pest in the EPPO region, and is considered of quarantine significance in South America.
Popillia japonica (Japanese beetle).
Authors: Klein Michael 
Published: June 2021

Abstract

The Japanese beetle was first discovered in New Jersey, USA in 1916. It probably entered the USA as grubs with iris bulbs before 1912 when plant materials were first examined. Although not a pest in Japan, extensive, well-watered, turf, and a lack of parasites, allowed populations to rapidly build up and spread steadily west to the Mississippi River. The loss of the chlorinated hydrocarbon insecticides, and the end of the Federal quarantine on nursery stock, has allowed beetles to move into western states at a rapid rate. Beetles are pests of quarantine concern in the western USA and Europe. P. japonica was found on Terceira Island, Azores, Portugal in the 1980s. Again, extensive turf allowed establishment of beetles, population explosions, the infestation of that island, and subsequently of three more of the Azorean Islands. Beetles have moved considerably outside of the climatic conditions in their native Japan.
Pectobacterium brasiliense (soft rot and blackleg of ornamentals and potato).
Authors: Joshi Janak Raj , Zeng Yuan , Charkowski Amy 
Published: June 2021

Abstract

Pectobacterium brasiliense is a bacterial pathogen primarily infecting potato and other vegetables and ornamentals. The earliest reports of the bacterium causing disease were from Brazil in 2004 (El-Tassa and Duarte, 2004; Duarte et al., 2004). This pathogen was reported for the first time in Europe (Belgium) in 2012 (van der Wolf et al., 2017). Since then, the pathogen has been reported in many regions of Europe, Asia, Africa, Australia, North and South America. The bacterium has adapted itself to a wide range of temperatures and host species, thus it is considered a culprit for significant losses in China, South Africa, Brazil, Netherlands, Switzerland and UK (Meng et al., 2017; van der Wolf et al., 2017). Symptoms caused by P. brasiliense are indistinguishable from other soft rot Pectobacterium and Dickeya, therefore it is impossible to identify this species on the basis of field and laboratory symptoms. Unfortunately, there is no evidence of curative measures and varietal resistance (in cultivated potatoes) against this group of bacteria, so farmers rely on seed certification, exclusion and sanitation to mitigate its worst effects.
Isolation and structural elucidation of novel fusicoccan dehydroxypericonicin A from Roussoella sp
Authors: Hayasaka Ayane , Tanaka Kazuaki , Hashimoto Masaru 
Published: June 2021

ABSTRACT
A potent antifungal fusicoccane dehydroxypericonicin A (1) was isolated from Roussoella sp. along with known allantofuranone (2). The relative structure of 1 was fully elucidated by NMR spectroscopic manner. The suggested relative structure was confirmed by density functional theory (DFT)-based 13C NMR chemical shift calculations. The absolute configuration was investigated by a spectral comparison of the experimental electronic circular dichroism spectrum with that based on the DFT calculations.
Comparative genome analysis reveals the presence of multiple quorum-sensing systems in plant pathogenic bacterium, Erwinia rhapontici
Authors: Morohoshi Tomohiro , Nameki Kanako , Someya Nobutaka 
Published: June 2021

ABSTRACT
We present the complete genome sequences of 3 Erwinia rhapontici strains, MAFF 311153, 311154, and 311155. These chromosome sequences contained variety types of luxI/luxR gene pair involved in acylhomoserine lactone biosynthesis and reception. Large-scale insertion sequence was observed in the indigenous plasmid of MAFF 311154 and contained eraI3/eraR3 gene pair that make possible to produce acylhomoserine lactone.
Establishment of epidemiological cut-off values for cefoselis, a new fourth-generation cephalosporin, against Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis and Pseudomonas aeruginosa
Authors: Li Xue , Jia Peiyao , Zhu Ying , Xu Yingchun , Yu Yunsong , Lv Yuan , Wang Minggui , Sun Ziyong , Lin Jie , Li Yun , Zheng Bo , Hu Fupin , Guo Yan , Chen Zhongju , Li Haixia , Zhang Ge , Zhang Jingjia , Kang Wei , Duan Simeng , Wang Tong , Jing Ran , Yang Qiwen 
Published: June 2021

Abstract

Objectives
To establish the epidemiological cut-off values (ECOFFs) for cefoselis against Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis and Pseudomonas aeruginosa.

Methods
We collected 2288 non-repetitive clinical isolates from five laboratories throughout four cities in China. The cefoselis MICs and inhibition zone diameters for all isolates were established using the broth microdilution method and the disc diffusion method following EUCAST guidelines. MIC ECOFFs were determined by visual estimation and ECOFFinder software. Zone diameter ECOFFs were set if a high correlation of MICs and inhibition zone diameters was found by Pearson correlation. Zone diameter ECOFFs were finally determined by the visual estimate method.

Results
MICs of cefoselis were distributed from 0.008 to &gt;256 mg/L for the four Enterobacterales species and from 0.25 to &gt;256 mg/L for P. aeruginosa. MIC ECOFFs were 0.125 mg/L for E. coli, K. pneumoniae and P. mirabilis, 0.25 mg/L for E. cloacae and 32 mg/L for P. aeruginosa. A high correlation of MICs and zone diameters was observed for all Enterobacterales (|r| &gt; 0.8, P &lt; 0.001) and a relatively high correlation was found for P. aeruginosa (|r| = 0.71, P &lt; 0.001). The zone diameter ECOFF was 24 mm for E. cloacae, E. coli and K. pneumoniae, 26 mm for P. mirabilis and 21 mm for P. aeruginosa.

Conclusions
We determined MIC and zone diameter ECOFFs for cefoselis against four Enterobacterales species and P. aeruginosa. The establishment of ECOFFs for cefoselis provides clinicians with helpful guidance to differentiate WT and non-WT pathogens.
System and capability of public health response to nuclear or radiological emergencies in China
Authors: Fu Xi-Ming , Yuan Long , Liu Qing-Jie 
Published: June 2021

Abstract
In order to respond to nuclear or radiological emergencies effectively and protect the physical and mental health of the public, the national-, provincial-, municipal- and county-level public health response systems for nuclear or radiological emergencies had been established in China by the end of twentieth century. The health administrative departments at all levels have established professional emergency response teams, continue to improve their own level of emergency response systems and operating mechanisms, enhance the capabilities of radiation injury treatment, radiation monitoring and protection through training and exercises and also pay attention to the logistical support for emergency response. In this article the organizations, management system and capabilities of public health response to nuclear or radiological emergencies in China are briefly introduced. We try to strengthen information exchange and cooperation with foreign counterparts in this field in the future, so as to jointly promote the development of preparedness and response for nuclear or radiological emergencies.
The protein modifier SUMO is critical for integrity of the Arabidopsis shoot apex at warm ambient temperatures
Authors: Hammoudi Valentin , Beerens Bas , Jonker Martijs J , Helderman Tieme A , Vlachakis Georgios , Giesbers Marcel , Kwaaitaal Mark , van den Burg Harrold A 
Published: June 2021

Abstract
SUMO is a protein modification whose conjugate levels peak during acute heat stress. Here, we found that SUMO is also critical for plant longevity when Arabidopsis experiences a prolonged non-damaging period of 28 °C. Thermo-lethality at 28 °C was seen in sumo1/2 knockdown mutants but not in any other mutant of the SUMO pathway tested. Autoimmunity due to low SUMO1/2 expression levels was not causal for this thermo-lethality. The role of SUMO in thermo-resilience was also distinct from its requirement for thermomorphogenesis—a growth response triggered by the same warm temperature, as only the latter response was also dependent on the SUMO ligase SIZ1. Thermo-resilience at 28 °C and (acquired) thermotolerance, a response that allows plants to recover and acclimate to brief extreme temperatures, both depend on the HEAT SHOCK TRANSCRIPTION FACTOR A1 (HSFA1). Acquired thermotolerance was, however, normal in the sumo1/2 knockdown mutant. Thus, SUMO-dependent thermo-resilience is potentially controlled in a different way from the protein damage pathway that underpins thermotolerance. Close inspection of shoot apices revealed that the cell patterning and tissue integrity of the shoot apex of the SUMO1/2 knockdown mutant was lost at 28 °C but not 22 °C. We thus describe a novel SUMO-dependent phenotype.
The ‘Strange Fruit’ of Flannery O’connor: Damning Monuments in Southern Literature and Southern History
Authors: Rowan Fannin Jordan 
Published: June 2021

Abstract
This article revisits Flannery O’Connor’s racialised Christophany in her short story, ‘The Artificial N*’, in light of contemporary tensions over Confederate monuments in America. It explores her grotesque Christ (manifest in a suburban lawn jockey) that mysteriously acts as a means of grace and effects repentance and reconciliation. It teaches us how to read this racist statuary within the grotesque history of Confederate monuments in the American South. By further situating her story and this history in the matrix of art and community, materiality and memory, her work is able to provide a damning theological critique of the current debate around monument removal, without which we may be content to absent offending sculptures but leave untouched our unreconciled communities and sinful social order.
Haydn and the Aesthetics of Naivety
Authors: Friedman Jacob 
Published: June 2021

Abstract
Contending with rapid urbanization in the eighteenth century, some writers advocated a better understanding of mankind in its most ‘natural’ state. This impulse manifested itself in the arts as an idealization of ‘naivety’. Yet this ideal began to fade in the nineteenth century as Romantics prioritized intense expressivity and engagement with raw emotional complexities of life. Naivety came to be seen as an irresponsible retreat from reality. Writers on both sides of this redefinition of naivety positioned Joseph Haydn as the model ‘naive’ composer. Celebrated in his lifetime for his musical wit, Haydn nonetheless was always closely associated with his unpretentious, rustic origins. This essay contextualizes the fascination with Haydn’s supposed naivety within cultural trends at the turn of the nineteenth century and beyond. It demonstrates how changing attitudes towards the aesthetic category of naivety can partly explain the vicissitudes of Haydn’s reception history in the eighteenth and nineteenth centuries.
Changing modality behaviour in the radio light curve of blazar PKS B1144 − 379
Authors: Said N M M , Ellingsen S P , Liu J , McCallum J N , Bignall H E , Shabala S , Reynolds C 
Published: June 2021

ABSTRACT
The highly variable BL Lac object PKS B1144 − 379 was monitored at 6.7 GHz using the Ceduna Radio Telescope with high cadence from 2003 to 2011. Intraday variations due to interstellar scintillation (ISS) were observed throughout the period. To complement our earlier analysis of the ISS and variability of this object, we have investigated the physical origin of changes in the modality of flux density distributions, calculated for ∼14 d observing blocks. Our analysis shows that the flux density distribution is primarily bimodal, but it changes to unimodal during the core brightening and jet expansion phases of the source. The presence of unimodal flux density distributions during these two phases is most likely due to the compactness of the scintillating component and the intrinsic evolution of the source. The existence of unimodality in the flux density distributions associated with specific phases of the source evolution also suggests that changes in the modality are unlikely due to multiple scattering screens. We propose that the physical origin of changes in the modality of the flux density distribution for PKS B1144 − 379 is most likely due to the combination of multiple bright jet features with interstellar scintillation along the line of sight between observer and source. This new approach complements our previous investigations of the temporal evolution of PKS B1144 − 379 that used interstellar scintillation and very long baseline interferometry, and the combination of these techniques provides a crucial starting point for understanding the system.
Diagnostics of homologous solar-surge plasma as observed by IRIS and SDO
Authors: Kayshap Pradeep , Singh Payal Rajdeep , Tripathi Sharad C , Padhy Harihara 
Published: June 2021

ABSTRACT
Surges have regularly been observed in mostly H α 6563 Å and Ca ii 8542 Å. However, surge responses to other prominent lines of the interface region (Mg ii k 2796.35 Å and h 2803.52 Å, O iv 1401.15 Å, Si iv 1402.77 Å) are not well studied. Here, the evolution and kinematics of six homologous surges are analysed using IRIS and AIA observations. These surges were observed on 2014 July 7 and were located very close to the limb. A differential emission measure analysis is performed on these surges where the coexistence of cool (log T/K = 6.35) and relatively hot (log T/K = 6.95) components has been found at the base. This demonstrates that the bases of surges undergo substantial heating. During the emission of these surges in the above-mentioned interface-region lines, reported here for the first time, two peaks have been observed in the initial phase of emission, where one peak is found to be constant while other one varies; i.e. is non-constant (observed red- to blueshifts across the surge evolution) in nature. This suggests the rotational motion of surge plasma. The heated base and rotating plasma suggest the occurrence of magnetic reconnection as the most likely trigger for homologous surges. During the emission of these surges, it is found that, despite them being optically thick (i.e. Rkh &lt; 2.0), central reversal was not observed for the Mg ii k and h lines. Further, Rkh increases with surge emission in time and it is found to have a positive correlation with Doppler velocity and negative with Gaussian width.
A Systematic Review to Compare Chemical Hazard Predictions of the Zebrafish Embryotoxicity Test With Mammalian Prenatal Developmental Toxicity
Authors: Hoffmann Sebastian , Marigliani Bianca , Akgün-Ölmez Sevcan Gül , Ireland Danielle , Cruz Rebecca , Busquet Francois , Flick Burkhard , Lalu Manoj , Ghandakly Elizabeth C , de Vries Rob B M , Witters Hilda , Wright Robert A , Ölmez Metin , Willett Catherine , Hartung Thomas , Stephens Martin L , Tsaioun Katya 
Published: June 2021

Abstract
Originally developed to inform the acute toxicity of chemicals on fish, the zebrafish embryotoxicity test (ZET) has also been proposed for assessing the prenatal developmental toxicity of chemicals, potentially replacing mammalian studies. Although extensively evaluated in primary studies, a comprehensive review summarizing the available evidence for the ZET’s capacity is lacking. Therefore, we conducted a systematic review of how well the presence or absence of exposure-related findings in the ZET predicts prenatal development toxicity in studies with rats and rabbits. A two-tiered systematic review of the developmental toxicity literature was performed, a review of the ZET literature was followed by one of the mammalian literature. Data were extracted using DistillerSR, and study validity was assessed with an amended SYRCLE's risk-of-bias tool. Extracted data were analyzed for each species and substance, which provided the basis for comparing the 2 test methods. Although limited by the number of 24 included chemicals, our results suggest that the ZET has potential to identify chemicals that are mammalian prenatal developmental toxicants, with a tendency for overprediction. Furthermore, our analysis confirmed the need for further standardization of the ZET. In addition, we identified contextual and methodological challenges in the application of systematic review approaches to toxicological questions. One key to overcoming these challenges is a transition to more comprehensive and transparent planning, conduct and reporting of toxicological studies. The first step toward bringing about this change is to create broad awareness in the toxicological community of the need for and benefits of more evidence-based approaches.