bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA MNX1-AS1 promotes ovarian cancer process via targeting the miR-744-5p/SOX12 axis
Authors: Shen Yang , Lv Mengmeng , Fang Yichen , Lu Jin , Wu Yuzhong 
Published: November 2021

Abstract
Purpose
Ovarian cancer (OC) is the most common malignancy in women with high mortality. Increasing studies have revealed that long non-coding RNA (lncRNA) MNX1-AS1 has a promoting effect on various cancers. However, the mechanisms of MNX1-AS1 in OC are still unclear. Therefore, this study focused on exploring the mechanisms of MNX1-AS1 in OC.

Materials and methods
The expression of SOX12 at the protein level was detected by western blot. Cell proliferation was detected by CCK8 assay and colony formation assay. Cell cycle and cell apoptosis were detected by flow cytometry. Wound-healing assay, transwell assay and western blot were used to detect the ability of cell migration and invasion. The target binding was confirmed through the luciferase reporter assay.

Results
The expression of MNX1-AS1 was increased in OC tumor tissues and cells. Elevated MNX1-AS1 expression is associated with advanced stage and lower overall survival rate. Knockdown of MNX1-AS1 inhibited cell proliferation, migration and invasion, blocked cell cycle, and promoted cell apoptosis in SKOV-3 and OVCAR-3 cells. MNX1-AS1 was competitively binding with miR-744-5p, and its downstream target gene was SOX12. miR-544-5p expression was decreased, while SOX12 expression was increased in OC tumor tissues and cells. Overexpression of miR-744-5p inhibited cell proliferation, migration, invasion and promoted cell apoptosis in SKOV-3 and OVCAR-3 cells.

Conclusion
MNX1-AS1 promoted the development of OC through miR-744-5p/SOX12 axis. This study revealed a novel mechanism of MNX1-AS1 in OC, which may provide a new treatment or scanning target for OC.
Effects of free range-of-motion upper limb exercise based on mirror therapy on shoulder function in patients after breast cancer surgery: study protocol for a randomized controlled trial
Authors: Yuan Ru-Zhen , Li Kun-Peng , Wei Xiao-Lin , Zheng Wei , Ye Yi , Wang Ming-Yue , Jiang Jie-Ting , Wu Cai-Qin 
Published: November 2021

Abstract
Background
Shoulder function complications are common after treatment for breast cancer. Quite a few survivors still report a limited shoulder range of motion, even though the free range-of-motion upper limb exercise is helpful to restore shoulder function. Mirror therapy (MT) is a classical and effective rehabilitation technique to recover motor and sensory function for the limbs; in addition, studies have reported that MT has an influence on patients with shoulder functional dysfunction including increasing shoulder range of motion, improving shoulder function scores, and decreasing pain scores. Here, we describe a protocol of a randomized controlled trial to explore if free range-of-motion upper limb exercise based on MT has efficacy on shoulder function in survivors after surgery of breast cancer.

Methods/design
This is a prospective, single-blind, two-arm randomized controlled trial. An estimated 70 participants will be randomly allocated to (1) the MT group or (2) the control group. The participants in the control group receive free range-of-motion upper limb exercise, and participants in the MT group will engage in free range-of-motion upper limb exercise based on MT. The intervention will start on the first day after surgery and be completed at 8 weeks after surgery. The primary outcome in this protocol is shoulder range of motion (ROM), while the Constant-Murley Score (CMS); Disability of the Arm, Shoulder, and Hand Questionnaire (DASH); Tampa Scale of Kinesiophobia (13-item TSK); visual analog scale (VAS); grip strength; arm circumference; and lymphedema are the secondary outcomes. Assessment will be conducted before allocation (baseline) and at 2 weeks, 4 weeks, and 8 weeks after surgery.

Discussion
Based on the results that MT has an influence on shoulder function immediately after intervention in patients without nerve injury, this randomized controlled trial is to observe the efficacy of MT on shoulder function after a long-term intervention in breast cancer survivors. We look forward to the innovation of this study for both breast cancer rehabilitation and MT.

Trial registration
Chinese Clinical Trial Registry (ChiCTR) ChiCTR2000033080. Registered on 19 May 2020
Applications of new contraction mappings on existence and uniqueness results for implicit ϕ-Hilfer fractional pantograph differential equations
Authors: Afshari Hojjat , Marasi H. R. , Alzabut Jehad 
Published: November 2021

AbstractIn this paper, we consider initial value problems for two different classes of implicit ϕ-Hilfer fractional pantograph differential equations. We use different approach that is based on $\alpha -\psi $
α
−
ψ
-contraction mappings to demonstrate the existence and uniqueness of solutions for the proposed problems. The mappings are defined in appropriate cones of positive functions. The presented examples demonstrate the efficiency of the used method and the consistency of the proposed results.
Fecal microbiota transplantation protects rotenone-induced Parkinson’s disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis
Authors: Zhao Zhe , Ning Jingwen , Bao Xiu-qi , Shang Meiyu , Ma Jingwei , Li Gen , Zhang Dan 
Published: November 2021

Abstract
Background
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder, displaying not only well-known motor deficits but also gastrointestinal dysfunctions. Consistently, it has been increasingly evident that gut microbiota affects the communication between the gut and the brain in PD pathogenesis, known as the microbiota-gut-brain axis. As an approach to re-establishing a normal microbiota community, fecal microbiota transplantation (FMT) has exerted beneficial effects on PD in recent studies. Here, in this study, we established a chronic rotenone-induced PD mouse model to evaluate the protective effects of FMT treatment on PD and to explore the underlying mechanisms, which also proves the involvement of gut microbiota dysbiosis in PD pathogenesis via the microbiota-gut-brain axis.

Results
We demonstrated that gut microbiota dysbiosis induced by rotenone administration caused gastrointestinal function impairment and poor behavioral performances in the PD mice. Moreover, 16S RNA sequencing identified the increase of bacterial genera Akkermansia and Desulfovibrio in fecal samples of rotenone-induced mice. By contrast, FMT treatment remarkably restored the gut microbial community, thus ameliorating the gastrointestinal dysfunctions and the motor deficits of the PD mice. Further experiments revealed that FMT administration alleviated intestinal inflammation and barrier destruction, thus reducing the levels of systemic inflammation. Subsequently, FMT treatment attenuated blood-brain barrier (BBB) impairment and suppressed neuroinflammation in the substantia nigra (SN), which further decreased the damage of dopaminergic neurons. Additional mechanistic investigation discovered that FMT treatment reduced lipopolysaccharide (LPS) levels in the colon, the serum, and the SN, thereafter suppressing the TLR4/MyD88/NF-κB signaling pathway and its downstream pro-inflammatory products both in the SN and the colon.

Conclusions
Our current study demonstrates that FMT treatment can correct the gut microbiota dysbiosis and ameliorate the rotenone-induced PD mouse model, in which suppression of the inflammation mediated by the LPS-TLR4 signaling pathway both in the gut and the brain possibly plays a significant role. Further, we prove that rotenone-induced microbiota dysbiosis is involved in the genesis of PD via the microbiota-gut-brain axis.
Improving the indoor air quality (IAQ) in naturally ventilated lecture hall with a single facade by solar chimneys
Authors: Fikry Ahmed , Elsayed Asmaa 
Published: November 2021

AbstractIn this paper, the indoor air pollution was investigated inside an educational building which contains air pollutants with elevated concentrations. A field study was conducted in a naturally ventilated, single-faceted lecture’s hall to evaluate the indoor air quality (IAQ). Both air velocity and carbon dioxide (CO2) concentrations were measured at the respiratory area level to compare these values with ASHRAE standard (62.01-2019). The computational fluid dynamics (CFD) 3D model was utilized to predict the air velocity, and CO2 concentrations, and to validate the measured air concentrations. The measured results fairly agree with the numerical CFD data with a 6.2% difference between both values. This paper deals with experimental work to study the effect of the cross-section area, the number, and the height of the solar chimneys. The results showed that using solar chimneys improved the natural ventilation in the hall and minimized the CO2 concentrations. Additionally, using the chimney cross-section area of 0.25*0.25 m, 0.30*0.30 m, and 0.40*0.40 to 0.50*0.50 m can reduce the CO2 concentrations to (3%, 6.2%, 6.4%, and 6.7%, respectively). While using three chimneys instead of only one, the ventilation flow rate increased from 61 to 70.9%. The effect of the height of the chimney on the average of CO2 concentrations inside the hall was examined. The modeled height rates (1, 3, 5, and 7 m, respectively) were improved to 26%, 33.6%, and 48.7%, respectively.
Impact of the first COVID-19 outbreak on mental health service utilisation at a Dutch mental health centre: retrospective observational study
Authors: Chow Man Wei , Noorthoorn Eric O. , Wierdsma André I. , van der Horst Marte , de Boer Nini , Guloksuz Sinan , Luykx Jurjen J. 
Published: November 2021

Background
Previous studies into mental health service utilisation during the COVID-19 pandemic are limited to a few countries or specific type of service. In addition, data on changes in telepsychiatry are currently lacking.

Aims
We aimed to investigate whether the COVID-19 pandemic is associated with changes in mental health service utilisation, including telepsychiatry, and how these changes were distributed among patients with mental illness during the first COVID-19 outbreak.

Method
This retrospective study obtained routinely assessed healthcare data from a large Dutch mental healthcare institute. Data from the second quarter of 2020 (the first COVID-19 outbreak period) were compared with the pre-pandemic period between January 2018 and March 2020. Time-series analyses were performed with the quasi-Poisson generalised linear model, to examine the effect of the COVID-19 lockdown and the overall trend of mental health service utilisation per communication modality and diagnostic category.

Results
We analysed 204 808 care contacts of 28 038 patients. The overall number of care contacts in the second quarter of 2020 remained the same as in the previous 2 years, because the number of video consultations significantly increased (B = 2.17, P = 0.488 × 10−3) as the number of face-to-face out-patient contacts significantly decreased (B = −0.98, P = 0.011). This was true for all different diagnostic categories, although this change was less pronounced in patients with psychotic disorders.

Conclusions
Diminished face-to-face out-patient contacts were well-compensated by the substantial increase of video consultations during the first COVID-19 outbreak in The Netherlands. This increase was less pronounced for psychotic disorders. Further research should elucidate the need for disorder-specific digital mental healthcare delivery.
Organic dye concentration monitoring through an optical microfiber enabled by multiwalled carbon nanotubes
Authors: Sun Dandan , Hao Yaohui , Fu Yongming , Ma Jie 
Published: November 2021

A tapered microfiber sensor based on multiwalled carbon nanotubes (MWCNTs) for detecting the concentration of alizarin red S dye is proposed and verified by experiments. MWCNTs fixed on the surface of optical fiber can adsorb the alizarin red S dye molecule due to its porous structure. The surface refractive index (RI) change caused by MWCNTs coated with the fiber surface adsorbing of red dye can be captured by optical microfiber, which converted into macroscopic wavelength drift in the interference spectrum. The sensor has a high RI sensitivity of 1942.25 nm/RIU and a temperature sensitivity of

−

0.03

n
m

/

∘

C

, which has a low temperature cross-sensitivity. The sensor provides rapid detection of alizarin red S dye in the concentration range of 0–1000 mg/L, and the sensitivity is 0.412 nm/(mg/L) in the low concentration range of 0–25 mg/L. The sensor is expected to be a high-quality platform for safety considerations in environmental protection.
Early childhood development and urban environment in Mexico
Authors: Prado-Galbarro Francisco-Javier , Pérez-Ferrer Carolina , Ortigoza Ana , López-Olmedo Nancy Paulina , Braverman-Bronstein Ariela , Rojas-Martínez Rosalba , de Castro Filipa , Barrientos-Gutiérrez Tonatiuh 
Published: November 2021

Background
Childhood is considered the most important phase of human development; within it the period from birth to 5 years of age is particularly critical, given the speed at which changes occur. The context where children live can influence early childhood developmnent (ECD) by providing or limiting opportunities to learn, play and establish social interactions. This study explored the associations between characteristics of the urban environment and ECD in 2,194 children aged 36 to 59 months living in urban municipalities in Mexico

Methods
We obtained ECD information from the 2015 Survey of Boys, Girls, and Women (ENIM, for its Spanish acronym), measured with the Early Childhood Development Index. The urban environment was evaluated at the municipal level, considering variables from five environment domains: physical, social, service, socioeconomic, and governance. Multilevel logistic models were fitted to assess the association between urban environment characteristics and the inadequacy of ECD in general and by specific development domains: learning, socio-emotional, physical, and alpha-numeric.

Results
Inadequate ECD was inversely associated with the availability of libraries (OR = 0.55, 95% CI: 0.43, 0.72), and positively associated with population density (OR = 1.01, 95% CI: 1.01–1.02). For the specific ECD domains, inadequate socio-emotional development was inversely associated with the availability of libraries (OR = 0.66, 95% CI: 0.51, 0.85). Inadequate literacy-numeracy knowledge was associated inversely with the availability of daycare centers (OR = 0.56, 95% CI: 0.32, 0.97), and directly associated with the number of hospitals and clinics (OR = 1.87, 95% CI: 1.29, 2.72). Finally, the marginalization index was positively associated with inadequacy in the learning domain (OR = 1.80, 95% CI: 1.06, 3.03).

Conclusions
Some aspects of the urban environment associated with ECD, suggest that intervening in the urban context could improve overall child development. Investment in resources oriented to improve socio-emotional development and literacy (such as libraries and daycare), could foster ECD in Mexico.
Fellowship program directors and trainees across the United States find parental leave policies to be inconsistent, inaccessible, and inadequate
Authors: Jamorabo Daniel Sabido , Khander Amrin , Koulouris Vasilios , Feith Jeremy Eli , Briggs William Matthew , Renelus Benjamin Dwight 
Published: November 2021

Introduction
Determine the consistency, accessibility, and adequacy of parental leave policies for adult and pediatric medicine fellowship programs.

Methods
We administered a 40-question survey to fellowship program directors (PDs) and trainees in adult and pediatric cardiology, hematology/oncology, gastroenterology, and pulmonology/critical care fellowship programs in the United States. We used Chi-square tests to compare proportions for categorical variables and t-tests to compare means for continuous variables.

Results
A total of 190 PDs from 500 programs (38.0%) and 236 trainees from 142 programs (28.4%) responded. Most respondents did not believe that parental leave policies were accessible publicly (322/426; 75.6%), on password-protected intranet (343/426; 80.5%), or upon request (240/426; 56.3%). The PDs and trainees broadly felt that parental leave for fellows should be 5–10 weeks (156/426; 36.6%) or 11–15 weeks (165/426; 38.7%). A majority of PDs felt that there was no increased burden upon other fellows (122/190; 64.2%) or change in overall well-being (110/190; 57.9%). When asked about the biggest barrier to parental leave support, most PDs noted time constrains of fellowship (101/190; 53.1%) and the limited number of fellows (43/190; 22.6%). Trainees similarly selected the time constraints of training (88/236; 37.3%), but nearly one-fifth chose the culture in medicine (44/236; 18.6%). There were no statistically significant differences in answers based on the respondents’ sex, specialty, or subspecialty.

Discussion
Parental leave policies are broadly in place, but did not feel these were readily accessible, standardized, or of optimum length. PDs and trainees noted several barriers that undermine support for better parental leave policies, including time constraints of fellowship, the limited number of fellows for coverage, and workplace culture. Standardization of parental leave policies is advisable to allow trainees to pursue fellowship training and care for their newborns without undermining their educational experiences.
On the brass ewer unearthed from the crypt of the Shang-fang Śarīra Stupa of Qingshan Monastery in Lintong District, Shaanxi
Authors: Li Yusheng , Li Jianxi , Niu Jiangtao 
Published: November 2021

Abstract
A cast brass ewer was unearthed from the Shangfang Śarīra Stupa crypt at Qingshan Monastery. Most likely, it was made in the northwestern part of the South Asian subcontinent in the late seventh century. Integrating ancient Roman, Sassanian, and early Islamic styles, the shape of this ewer not only is a mixture of the elements of different eras and traditions but also reflects unique attributes. The multi-headed and multi-armed deities from Hinduism, especially Skanda, may have inspired the six-faced design on the body. Eventually, the ewer was taken to Chang’an by Indian or Kashmirian monks and buried in the pagoda’s crypt.
Modeling in semiotics: an integrative update
Authors: Yu Hongbing 
Published: November 2021

Abstract
This paper provides an integrative and updated view of modeling in semiotics. It postulates that the essence of modeling is supersession. In any act or instance of modeling, the model supersedes and is brought to the front for salience, accessibility, and operability, whereas at the same time the modeled recedes and exists in the background, inaccessible and inoperable. The paper goes on to differentiate between two major types of modeling, the underlying “existential modeling,” functioning as the fundamental scaffold and the genuine foundation of all other types of modeling as we know them, and the overlaying “semiotic modeling,” designating the process of creation and use of “forms of meaning,” a process that underlies both cognition and communication. By focusing on semiotic modeling, the paper features an unconventional view that casts a new light on the relation between a model and a sign and thus the relation between semiotic modeling and semiosis. Endorsing an embodied approach to meaning-making as semiotic modeling, the paper finds it important to stress the appropriateness and necessity of understanding the term “model” as a verb rather than as a noun, in that modeling is never static and should be properly regarded in terms of embodied action.
Serendipity or a Missed Chance? On the Interaction Between Vaccine Distribution and the EU Recovery Funds
Authors: Macchiarelli Corrado , Giacon Renato 
Published: November 2021

Abstract
In this article, we discuss the interaction between the Covid-19 vaccine rollout in EU member states and the effective use of grants and soft loans from the EU pandemic recovery fund. With some of the national spending plans for the Recovery Fund still awaiting initial submission (Bulgaria), others pending the Commission’s endorsement (Poland, Hungary) or formal Council’s approval (Romania, Estonia), and various other national plans in their implementation stage, the next challenge for policymakers will be to ensure that the initial and subsequent tranches of EU funds are released as economies reopen. We claim that special attention ought to be paid to Central and Eastern Europe, where some countries are lagging in their vaccine rollout and/or the preparation for their use of the EU recovery funds. This is likely to be an important test for EU institutions in determining the stability and coherence of the European project as a whole.
Wavelength-dependent photodegradation of wood and its effects on fluorescence
Authors: Peters Frank B. , Rapp Andreas O. 
Published: November 2021

Abstract
Apart from some strongly fluorescent wood species, the general fluorescence of wood has long been ignored. Recent studies suggest that each species has a distinct fluorescence, originating from both basic components and characteristic extractives. However, wood colour and fluorescence rapidly change upon exposure to sunlight. In this study, 288 samples of Acer pseudoplatanus, Quercus robur, Picea abies and Juglans nigra were irradiated with different bands of ultraviolet (UV) and visible (VIS) light. Photosensitivity was examined in regards of colour, infrared absorbance (FTIR), and fluorescence imaging. UV light caused strong yellowing in all examined species, mostly correlating with lignin degradation, carbonyl formation and the appearance of a broad banded fluorescence emission. VIS light above 420 nm, however, caused different, partly contradicting effects in colour and fluorescence, and did not affect lignin. J. nigra proved to be most sensitive towards VIS-induced yellowing and bleaching. The main new finding of this study is that the native long wave fluorescence of wood was strongly decreased by VIS-irradiation above 510 nm wavelength in all samples. This effect was not species-specific, probably originating from a cross-species wood component. The results have potential impacts on non-destructive image-based evaluation methods and wood identification.
Poéticas urbanas de loinforme: exploraciones subterráneas de la Ciudad de México en la literatura contemporánea
Authors: François Liesbeth 
Published: November 2021

ResumenEste artículo estudia dos obras recientes que exploran la Ciudad de México desde la movilidad subterránea del metro:La penumbra inconveniente(2001) de Mauricio Montiel Figueiras yLos ingrávidos(2013) de Valeria Luiselli. Se demuestra que la perspectiva “desde abajo” en estos textos implica un cuestionamiento de la mirada estética predominante, que enfatiza el carácter caótico de la megalópolis desde una posición normativa. A partir del concepto de loinformede Martin Jay, el análisis iluminará cómo el movimiento bajo tierra apunta hacia una poética urbana alternativa, que encuentra su potencial estético en la disolución de las identidades y estructuras urbanas.