bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perinatal results of antenatally detected hypoplastic left heart syndrome in a single tertiary center: experience of 5 years time
Authors: SAHİNGOZ YİLDİRİM Alkim Gulsah , SEVER Barış , GÖLBAŞI Hakan , ÖMEROĞLU İbrahim , EMİRALİOĞLU ÇAKIR Zübeyde , OZER Mehmet , GOLBASİ Ceren , EKİN Atalay , PALA Halil Gürsoy , ÖZEREN Mehmet 
Published: September 2021

Abstract
Aim: Our aim is to investigate Hypoplastic Left Heart Syndrome diagnosed pregnancies that were followed up in Tepecik Education and Research Hospital- Perinatology Unit between 2015-2020, retrospectively.
Matherials and Methods: The archieves were scanned retrospectively. Maternal features such as age, gravidy, parity, teratogen exposure, concominant disease existence, karyotyping rejection and decision for the pregnancies future and delivery type was noted. Also fetal features like gestational age at diagnosis, fetal growth, perinatal complications (eg: intrauterin growth retardation, additional anomaly, preterm delivery) and postnatal condition was noted.
Results: 9 of the 41 patients met the criteria. One of them had termination of the pregnancy. %37.5 of the rest had preterm delivery. 3 of the 8 patients (%37,5) had intrauterin growth retardation with estimated fetal weight below 10 persentile. There were no gender difference among infants. 75 percent of delivered infants, were operated postnataly. 2 of the infants were died before operation due to prematurity complications.
Discussion: Hypoplastic Left Heart Syndrome is a very rare condition highly detectable in the antenatal period with high morbidity and mortality rates. These fetuses must be followed up in tertiary centers both because of antenatal problems’ management and postnatal management.
Keywords: Hypoplastic Left Heart Syndrome, fetal echocardiography
Clima y formas de vida de las plantas en la transición andina - extraandina de la Patagonia septentrional argentina
Authors: Dezzotti Alejandro , Medina Andrea , Mortoro Ariel 
Published: September 2021

Introducción y objetivos: La autolocomoción restringida expone a las plantas a estrés, que promueve la adaptación. En el ecotono andino - extraandino de la Patagonia argentina, la adaptación está asociada principalmente a la aridez. En este trabajo se investigó la adaptación de las plantas al frío, basada en el análisis de las formas de vida que representan una estrategia de supervivencia durante la estación desfavorable.
M&M: En Aguas Frías (38° 46´ S, 70° 54´ O) y Litrán (38° 54´ S, 71° 01´ O), se caracterizó el clima a través de información meteorológica y la vegetación en forma fisonómico - florística. Las plantas se clasificaron de acuerdo a la especie, el origen, la forma de crecimiento y la forma de vida, y la abundancia se estimó a través de datos de incidencia.
Resultados: El clima es templado frío húmedo - semiárido y la vegetación corresponde a las Provincias Patagónica y Subantártica. Las unidades de vegetación incluyeron bosques, estepas y praderas. La riqueza total fue 148; 139 especies fueron nativas, 122 herbáceas, 143 raras y 64 pertenecieron a una única unidad. La similitud entre unidades fue baja y las hemicriptófitas dominaron los espectros biológicos florístico (68%) y vegetacional (56%).
Conclusiones: El intenso gradiente ambiental modeló las marcadas diferencias de la vegetación, y el frío habría sido un factor clave a juzgar por la dominancia de un forma de vida adaptada a las bajas temperaturas. Una mayor comprensión de estas relaciones es esencial para el manejo de los ecosistemas patagónicos.
The Relationship Between Oxygen Uptake and the Rate of Myocardial Deformation During Exercise
Authors: van Zalen Jet , D'Silva Andrew , Badiani Sveeta , Bhuva Anish N. , Patel Nikhil , Hughes Alun , Manisty Charlotte , Sharma Sanjay , Moon James C. , Lloyd Guy W. 
Published: September 2021

ABSTRACT

Background:
The relationship between resting echocardiographic measures of cardiac function and exercise capacity is weak. The details of ventricular augmentation may provide insight into determinants of cardiac efficiency for optimal exercise performance. The aims of this study were to establish how much of the variability in exercise performance could be explained by myocardial recruitment and which parameters describing cardiac function were most closely related to exercise performance.

Methods:
Untrained volunteers were recruited before training for the London Marathon. All performed a cardiopulmonary exercise test combined with stress echocardiography. Systolic and diastolic longitudinal velocities (S′ and E′), left ventricular ejection fraction (LVEF), stroke volume (SV), and strain (GLS) were obtained throughout exercise.

Results:
A variety of parameters including S′, E′, GLS, and SV showed a correlation with V̇o2 throughout exercise (ρ = 0.83, P &lt; 0.0001). At the prespecified sample point (respiratory exchange ratio &gt; 1.0) only SV and S′ were predictive of V̇o2peak. LVEF and E′ as well as both global longitudinal and circumferential strain showed no correlation with V̇o2peak. The systolic efficiency slope (SES) that we developed by determining the individual regression lines for V̇o2 and S′ showed a relationship between with V̇o2 peak for both septal S′, r = 0.57, P &lt; 0.001, and lateral S′, r = 0.53, P &lt; 0.001.

Conclusion:
A detailed description of myocardial function is described, linear for S′ and E′ and a plateau for EF and GLS. S′ during exercise is a better predictor of exercise performance than LVEF, SV, or GLS. The SES slope predicted V̇o2peak, suggesting the process driving systolic velocity and its augmentation is a key determinant of exercise ability.
La mobilisation redoutée de l’épargne privée
Authors: Masclet De Barbarin Marie 
Published: September 2021

La crainte de voir l’État ponctionner l’épargne des ménages pour sortir de la crise revient souvent ces derniers temps sur le devant de la scène médiatique. Cette hypothèse s’appuie notamment sur l’expérience malheureuse des épargnants chypriotes en 2013, qui ont dû pour certains d’entre eux recapitaliser leur banque sur leurs propres deniers.
Si aucun autre précédent de mobilisation contrainte de l’épargne privée n’est pour l’instant à déplorer en Europe, il faut savoir qu’il existe à présent dans notre droit français des instruments juridiques susceptibles d’autoriser de telles mesures d’exception. Elles ne pourraient cependant être mises en oeuvre qu’en cas de crise financière majeure et s’accompagneraient de dispositifs de protection destinés à en limiter l’impact pour le plus grand nombre.
Fiscalité de crise ou crise de la fiscalité internationale ?
Authors: Davoult Nicole 
Published: September 2021

Les règles fiscales internationales ont été adaptées à la pandémie dans l’urgence sans créer a priori de contraintes, afin de garantir la sécurité juridique. Les analyses de l’OCDE, ainsi que celles de l’administration et la jurisprudence, portent sur la localisation des contribuables, fondée sur le concept de résidence dont la portée serait peu modifiée pour les personnes physiques, contrairement aux entreprises, et sur la répartition du pouvoir d’imposer à travers l’établissement stable et les prix de transfert qui seraient plus fortement impactés.
Le système international de répartition fait parallèlement l’objet d’une réforme par l’OCDE en 2020, initialement en réponse aux enjeux de la numérisation de l’économie. Le Pilier Un porte sur la répartition des droits d’imposition entre les pays et vise notamment à l’orienter davantage au profit des juridictions de marché, pour les activités reposant à des degrés divers sur des services numériques, avec un nouveau lien de nature économique (« nexus »). Le Pilier Deux prévoit que les sociétés multinationales paient un impôt minimum sur leurs bénéfices si leur taux effectif d’imposition est inférieur à ce plancher. Avec le soutien des États-Unis, cette proposition dont l’incidence budgétaire est limitée pourra être adoptée dans le contexte d’une crise qui renforce les demandes de solidarité internationale.
Risk factors for lymphedema after breast surgery: A prospective cohort study in the era of sentinel lymph node biopsy
Authors: Salinas-Huertas S. , Luzardo-González A. , Vázquez-Gallego S. , Pernas S. , Falo C. , Pla M.J. , Gil-Gil M. , Beranuy-Rodriguez M. , Pérez-Montero H. , Gomila-Sancho M. , Manent-Molina N. , Arencibia-Domínguez A. , Gonzalez-Pineda B. , Tormo-Collado F. , Ortí-Asencio M. , Terra J. , Martinez-Perez E. , Mestre-Jane A. , Campos-Varela I. , Jaraba-Armas M. , Benítez-Segura A. , Campos-Delgado M. , Fernández-Montolí M.E. , Valverde-Alcántara Y. , Rodríguez A. , Campos G. , Guma A. , Ponce-Sebastià J. , Planas-Balagué R. , Catasús-Clavé M. , García-Tejedor A. 
Published: September 2021

INTRODUCTION: The Objective was to investigate the incidence of lymphedema after breast cancer treatment and to analyze the risk factors involved in a tertiary level hospital. METHODS: Prospective longitudinal observational study over 3 years post-breast surgery. 232 patients undergoing surgery for breast cancer at our institution between September 2013 and February 2018. Sentinel lymph node biopsy (SLNB) or axillary lymphadenectomy (ALND) were mandatory in this cohort. In total, 201 patients met the inclusion criteria and had a median follow-up of 31 months (range, 1–54 months). Lymphedema was diagnosed by circumferential measurements and truncated cone calculations. Patients and tumor characteristics, shoulder range of motion limitation and local and systemic therapies were analyzed as possible risk factors for lymphedema. RESULTS: Most cases of lymphedema appeared in the first 2 years. 13.9% of patients developed lymphedema: 31% after ALND and 4.6% after SLNB (p < 0.01), and 46.7% after mastectomy and 11.3% after breast-conserving surgery (p < 0.01). The lymphedema rate increased when axillary radiotherapy (RT) was added to radical surgery: 4.3% for SLNB alone, 6.7% for SLNB + RT, 17.6% for ALND alone, and 35.2% for ALND + RT (p < 0.01). In the multivariate analysis, the only risk factors associated with the development of lymphedema were ALND and mastectomy, which had hazard ratios (95% confidence intervals) of 7.28 (2.92–18.16) and 3.9 (1.60–9.49) respectively. CONCLUSIONS: The main risk factors for lymphedema were the more radical surgeries (ALND and mastectomy). The risk associated with these procedures appeared to be worsened by the addition of axillary radiotherapy. A follow-up protocol in patients with ALND lasting at least two years, in which special attention is paid to these risk factors, is necessary to guarantee a comprehensive control of lymphedema that provides early detection and treatment.
Comparison between ultrasound-guided monopolar and bipolar pulsed radiofrequency treatment for refractory chronic cervical radicular pain: A randomized trial
Authors: Lee Sang Hoon , Choi Hyun Hee , Chang Min Cheol 
Published: September 2021

BACKGROUND: Many patients complain of chronic cervical radicular pain, and pulsed radiofrequency (PRF) is known to have a positive effect for alleviating neuropathic pain. OBJECTIVES: In the present study, we used ultrasound (US) guidance and compared the effects of monopolar PRF with those of bipolar PRF in patients with chronic cervical radicular pain refractory to repeated transforaminal epidural steroid injections. METHODS: Sixty-six patients with chronic cervical radicular pain were included in this study. Patients were randomly assigned to one of the two groups: monopolar or bipolar PRF group (n= 33 per group). Pain intensity was evaluated using a numeric rating scale (NRS) at pretreatment, and at 1 and 3 months after the treatment. Target stimulation site was the extraforaminal nerve root. RESULTS: Compared to the pretreatment NRS scores, patients in both groups showed a significant decrease in NRS scores at 1 and 3 months after the treatment. Reductions in the NRS scores over time were significantly larger in the bipolar PRF group. Three months after the treatment, 18 patients (54.5%) in the monopolar PRF group and 27 (81.8%) in the bipolar PRF group reported successful pain relief (pain relief of ⩾50%). CONCLUSIONS: US-guided PRF can be an effective interventional technique for the management of chronic refractory cervical radiculopathy. Moreover, bipolar PRF has better treatment outcome than monopolar PRF.
PENENTUAN POLA PEMBELIAN OBAT MENGGUNAKAN ALGORITMA APRIORI
Authors: Syahrir Moch , Rismayanti Ria , Wicaksono Moh Arief 
Published: September 2021

Apotek merupakan salah satu usaha yang bergerak dalam bidang kesehatan khususnya pelayanan produk dan jasa untuk meningkatkan kesehatan masyarakat. Pelayanan produk dan jasa untuk meningkatkan kesehatan masyarakat ini dilakukan oleh seorang pengelola apotek dalam upaya memenuhi tugas dan fungsi apotek yang meliputi perencanaan, pengorganisasian, pelaksanaan, pengawasan dan penilaian. Hal ini menyebabkan adanya permasalahan yang sering terjadi diapotek yaitu dalam melakukan pencarian obat harus dilakukan dengan mencari satu persatu dalam buku transaksi penjualan obat karena pengelola apotek tidak mengetahui stok obat yang ada di apotek. Selain itu permasalahan lainnya adalah pengaturan tata letak obat yang tidak teratur atau tidak terstruktur dimana peletakan obat tidak menggunakan acuan seperti obat yang paling laku.
Metode yang digunakan dalam membuat aplikasi ini yaitu asosiasi dengan menggunakan algoritma apriori yang dimuai dari pengumpulan data yang merupakan data transaksi dan analisis kebutuhan data. Kemudian penulis membangun aplikasi dengan mengimplementasikan algoritma apriori pada aplikasi yang akan dibangun, pengujian aplikasi menggunakan 3 nilai minimum support dan 3 nilai minimum confidence agar nantinya bisa mendapatkan hasil rule dan k-Itemset dari ke 3 nilai yang berbeda tersebut.
A Novel Diagnostic Predictive Model for Idiopathic Short Stature in Children
Authors: Yuan Jinghong , Du Zhi , Wu Zhiwen , Yang Yanqin , Cheng Xigao , Liu Xijuan , Jia Jingyu 
Published: September 2021

ObjectiveIdiopathic short stature (ISS), an endocrine-related disease, is difficult to diagnose. Previous studies have shown that many children with some inflammation-related diseases often have short stature, but whether inflammation is the underlying mechanism of ISS has not been studied. Here, we attempt to explore the role of inflammation in the occurrence and development of ISS and to demonstrate an available clinical diagnostic model of ISS.MethodsFrozen serum samples were collected from ISS patients (n = 4) and control individuals (n = 4). Isobaric tags for relative and absolute quantitation (iTRAQ) combined with LC-MS/MS analysis were applied to quantitative proteomics analysis. To assess clusters of potentially interacting proteins, functional enrichment (GO and KEGG) and protein-protein interaction network analyses were performed, and the crucial proteins were detected by Molecular Complex Detection (MCODE). Furthermore, serum levels of two selected proteins were measured by ELISA between ISS patients (n = 80) and controls (n = 80). In addition, experimentsin vitrowere used to further explore the effects of crucial proteins on endochondral ossification.ResultsA total of 437 proteins were quantified, and 84 DEPs (60 upregulated and 24 downregulated) were identified between patients with ISS and controls. Functional enrichment analysis showed that the DEPs were primarily enriched in blood microparticle, acute inflammatory response, protein activation cascade, collagen-containing extracellular matrix, platelet degranulation, etc. According to the results of top 10 fold change DEPs and MCODE analysis, C1QA and C1QB were selected to further experiment. The expression levels of C1QA and C1QB were validated in serum samples. Based on the logistic regression analysis and ROC curve analysis, we constructed a novel diagnostic model by serum levels of C1QA and C1QB with a specificity of 91.2% and a sensitivity of 75% (AUC = 0.900, p &lt;0.001). Finally, the western blotting analysis confirmed the expression levels of OCN, OPN, RUNX2, and Collagen X were downregulated in chondrocytes, and the outcome of Collagen II was upregulated.ConclusionOur study is the first to demonstrate the significant role of inflammation in the development of ISS. In addition, we identify C1QA and C1QB as novel serum biomarkers for the diagnosis of ISS.
Transcriptome Analysis of Ostrinia furnacalis Female Pheromone Gland: Esters Biosynthesis and Requirement for Mating Success
Authors: Yao Shuangyan , Zhou Shuai , Li Xiang , Liu Xiaoguang , Zhao Wenli , Wei Jizhen , Du Mengfang , An Shiheng 
Published: September 2021

Female moths use sex pheromones to attract males, and corresponding regulatory mechanism underlying sex pheromone biosynthesis is species-dependent. However, the detailed mechanism involved in sex pheromone biosynthesis in Ostrinia furnacalis has not yet been fully addressed. In the present study, transcriptome sequencing of O. furnacalis pheromone glands screened a serials of candidate genes involved in sex pheromone biosynthesis. Our analysis showed that sex pheromone release in O. furnacalis females arrives its peak at the 2nd scotophase, consistent with its mating behavior. Pheromone biosynthesis-activating neuropeptide (PBAN) was confirmed to regulate sex pheromone biosynthesis, and Ca2+ is the secondary messenger of PBAN signaling in O. furnacalis. The functional analysis of candidate genes demonstrated that the decreased mRNA levels or activities of calcineurin (CaN) and acetyl-CoA carboxylase (ACC) led to significant decrease in sex pheromone production and female capability to attract males, as demonstrated by RNAi-mediated knockdown and pharmacological inhibitor assay. Most importantly, the activities of CaN and ACC depend on the activation of PBAN/PBANR/Ca2+. Furthermore, fatty-acyl reductase 14 was involved in PBAN-mediated sex pheromone biosynthesis. Altogether, our results demonstrated that PBAN regulates sex pheromone biosynthesis through PBANR/Ca2+/CaN/ACC pathway to promote sex pheromone biosynthesis in O. furnacalis and provided a reference for non-model organism to study neuropeptide signal transduction.
Integrative Analysis Reveals Potentially Functional N6-Methylandenosine-Related Long Noncoding RNAs in Colon Adenocarcinoma
Authors: Tan Xinjie , Li Qian , Zhang Qinya , Fan Gang , Liu Zhuo , Zhou Kunyan 
Published: September 2021

N6-methyladenosine (m6A) is one of the most prevalent RNA modifications in mRNA and non-coding RNA. In this study, we identified 10 upregulated m6A regulators at both mRNA and protein levels, and 2,479 m6A-related lncRNAs. Moreover, the m6A-related long noncoding RNAs (lncRNAs) could clearly stratify the colon adenocarcinoma (COAD) samples into three subtypes. The subtype 2 had nearly 40% of samples with microsatellite instability (MSI), significantly higher than the two other subtypes. In accordance with this finding, the inflammatory response-related pathways were highly activated in this subtype. The subtype-3 had a shorter overall survival and a higher proportion of patients with advanced stage than subtypes 1 and 2 (p-value &lt; 0.05). Pathway analysis suggested that the energy metabolism-related pathways might be aberrantly activated in subtype 3. In addition, we observed that most of the m6A readers and m6A-related lncRNAs were upregulated in subtype 3, suggesting that the m6A readers and the m6A-related lncRNAs might be associated with metabolic reprogramming and unfavorable outcome in COAD. Among the m6A-related lncRNAs in subtype 3, four were predicted as prognostically relevant. Functional inference suggested that CTD-3184A7.4, RP11-458F8.4, and RP11-108L7.15 were positively correlated with the energy metabolism-related pathways, further suggesting that these lncRNAs might be involved in energy metabolism-related pathways. In summary, we conducted a systematic data analysis to identify the key m6A regulators and m6A-related lncRNAs, and evaluated their clinical and functional importance in COAD, which may provide important evidences for further m6A-related researches.
Potential Cross-Reactive Immunity to COVID-19 Infection in Individuals With Laboratory-Confirmed MERS-CoV Infection: A National Retrospective Cohort Study From Saudi Arabia
Authors: Khan Anas A. , Alahmari Ahmed A. , Almuzaini Yasir , Alamri Fahad , Alsofayan Yousef Mohammad , Aburas Alhanouf , Al-Muhsen Saleh , Van Kerkhove Maria , Yezli Saber , Ciottone Gregory R. , Assiri Abdullah M. , Jokhdar Hani A. 
Published: September 2021

BackgroundA growing number of experiments have suggested potential cross-reactive immunity between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and previous human coronaviruses. We conducted the present retrospective cohort study to investigate the relationship between previous Middle East respiratory syndrome-coronavirus (MERS-CoV) infection and the risk of SARS-CoV-2 infection as well as the relationship between previous MERS-CoV and COVID-19-related hospitalization and mortality.MethodsStarting in March 2020, we prospectively followed two groups of individuals who tested negative for COVID-19 infection. The first group had a previously confirmed MERS-CoV infection, which was compared to a control group of MERS-negative individuals. The studied cohort was then followed until November 2020 to track evidence of contracting COVID-19 infection.FindingsA total of 82 (24%) MERS-positive and 260 (31%) MERS-negative individuals had COVID-19 infection. Patients in the MERS-positive group had a lower risk of COVID-19 infection than those in the MERS-negative group (Risk ratio [RR] 0.696, 95% confidence interval [CI] 0.522-0.929; p =0.014). The risk of COVID-19-related hospitalization in the MERS-positive group was significantly higher (RR 4.036, 95% CI 1.705-9.555; p =0.002). The case fatality rate (CFR) from COVID-19 was 4.9% in the MERS-positive group and 1.2% in the MERS-negative group (p =0.038). The MERS-positive group had a higher risk of death than the MERS-negative group (RR 6.222, 95% CI 1.342-28.839; p =0.019). However, the risk of mortality was similar between the two groups when death was adjusted for age (p =0.068) and age and sex (p =0.057). After controlling for all the independent variables, only healthcare worker occupation and &gt;1 comorbidity were independent predictors of SARS-CoV-2 infection.InterpretationIndividuals with previous MERS-CoV infection can exhibit a cross-reactive immune response to SARS-CoV-2 infection. Our study demonstrated that patients with MERS-CoV infection had higher risks of COVID-19-related hospitalization and death than MERS-negative individuals.
Deterministic Transfer of Large-Scale β-Phase Arsenic on Fiber End Cap for Near-Infrared Ultrafast Pulse Generation
Authors: Yu Qiang , Chen Cheng , Guo Kun , Deng Haiqin , Yi Tianan , Zhang Yan , Su Wei , Wu Jian , Zhang Kai 
Published: September 2021

Gray arsenic (β-phase) has aroused great attention in photonics and electronics applications, as a novel family member of two-dimensional (2D) elemental crystals of group-VA. Here, β-phase arsenic (β-As) bulk crystals were synthesized via the chemical vapor transport (CVT) method. Meanwhile, large-scale β-As nanoflake was transformed using the polydimethylsiloxane (PDMS)-assisted dry transfer method and was placed on the end cap of optical fiber with high coverage over the core area. Moreover, the β-As was used as a saturable absorber in ytterbium-doped fiber ring cavity resonance, and we demonstrated near-infrared ultrafast pulse fiber laser with the central wavelength, repetition rate, and signal-to-noise ratio (SNR) of 1,037.3 nm, 0.6 MHz, and 67.7 dB, respectively. This research demonstrates a 2D material small area deterministic transfer method and promotes the potential application of group-VA crystals in near-infrared ultrafast laser generation.