bluuebunny/crossref_metadata_2025_split huggingface dataset:
Die Bakerzyste – das stumpfe Damoklesschwert bei der Radiosynoviorthese (RSO)?
Authors: Kampen Willm Uwe , Freudenberg Lutz S , Fischer Manfred , Klett Rigobert 
Published: October 2021

ZusammenfassungDie popliteale Bakerzyste galt lange Zeit als Kontraindikation bei der Durchführung einer Radiosynoviorthese (RSO). Insbesondere bei einem vorliegenden „Ventilmechanismus“ der Zyste fürchtete man eine vermehrte Anreicherung des intraartikulär injizierten Radiopharmazeutikums Yttrium-90-Kolloid in der Zyste, die aus einer mit der Kniegelenkhöhle kommunizierenden Bursa unter dem medialen Kopf des M. gastrocnemius bei chronischer Arthritis mit Ergussneigung entstehen kann. Aufgrund der im Vergleich zur Kniegelenkkapsel deutlich dünneren Zystenwand wurde die Gefahr einer radiogenen Zystenruptur mit konsekutiver Freisetzung des hoch energetischen Betastrahlers in die umgebenden Weichteile und einer dadurch hervorgerufenen Weichteilnekrose diskutiert. Daher ist vor der Kniegelenk-RSO zwingend die sonografische Abklärung einer möglichen Bakerzyste erforderlich. Neue Studien zeigen hingegen keinen Hinweis auf die Gefahr einer Zystenruptur durch eine lege artis durchgeführte Kniegelenk-RSO.Bei bereits präexistierender Zystenwandruptur ist jedoch die Gefahr eines unkontrollierten Austritts des Radiopharmazeutikums mit nachfolgender Radionekrose auch weiterhin gegeben. Die Magnetresonanztomografie (MRT) ist die Methode der Wahl, um eine solche Zystenruptur im Vorfeld auszuschließen, liefert aber nicht immer zuverlässige Befunde. In derartigen Fällen ist die Binnenraumszintigrafie unter Verwendung von Tc-99m-Nanokolloid geeignet, die Integrität der Bakerzyste nachzuweisen und einen möglichen Aktivitätsaustritt aus der Zyste mit hinreichender Sicherheit auszuschließen. Die vorliegende Arbeit erläutert diese Methode an repräsentativen Fallbeispielen.
Aggressive systemic mastocytosis with diffuse bone marrow 18F-FDG uptake
Authors: Koukalová Renata , Vašina Jiří , Štika Jiří , Doubek Michael , Szturz Petr 
Published: October 2021

AbstractMastocytosis is a clonal hematopoietic disorder characterized by proliferation of abnormal mast cells in various organs including the skin, digestive system, lymph nodes, and bone marrow. We report on a 75-year-old woman presenting with abdominal pain, vomiting, diarrhoea, myalgia, and weight loss. Abdominal CT showed hepatosplenomegaly with heterogeneous splenic parenchyma, lymphadenopathy, and osteopenia with areas of osteosclerosis but no primary tumour. An 18F-FDG PET/CT revealed an overall low metabolic activity of the lesions with a diffuse bone marrow involvement raising suspicion of a haematological neoplasm. Subsequently, bone marrow and peripheral blood examinations confirmed the diagnosis of aggressive systemic mastocytosis.
Diarylamines with the Neighboring Pyridyl Group: Synthesis and Modulation of the Amine Functionality via Intramolecular H-Bonding
Authors: Magdesieva Tatiana V. , Levitskiy Oleg A. , Klimchuk Ivan A. , Grishin Yuri K. , Roznyatovsky Vitaly A. , Tarasevich Boris N. 
Published: October 2021

AbstractNew pyridyl-containing diarylamines were obtained via Cu-assisted reductive amination of the ortho-2-pyridylarylboronic acids. Comparative analysis of the spectral and electrochemical data obtained for new diarylamines and their pyridyl-free counterparts revealed the intramolecular H-bond (IMHB) formation which significantly influences the properties of the amino group. The electron density at the N atom of the amino group is increased due to partial weakening of the N–H bond, although the BDE and activation energy for the H-atom abstraction is increased due to the chelating effect of two N atoms. The ortho-pyridyl-containing diarylamines are more prone to be oxidized as compared to their pyridyl-free counterparts; the shift in the oxidation potential values correlates with the strength of the intramolecular H-bonding which can be tuned by inserting substituents in the pyridyl or phenyl rings. The IMHB is reserved even in polar solvents having a significant H-acceptor ability (such as DMSO) but can be destroyed in methanol, testifying in favor of the dynamic nature of the H-bonding.
The Application of 1,2-Oxazinanes as Chiral Cyclic Weinreb Amide-Type Auxiliaries Leading to a Three-Component, One-Pot Reaction
Authors: Hilt Gerhard , Fährmann Jan , Hermann Ludmila 
Published: October 2021

Abstract1,2-Oxazines were synthesised via a copper-catalysed aerobic acyl nitroso Diels–Alder reaction from 1,4-disubstituted 1,3-dienes and N-Boc-hydroxylamine. From this, 1,2-oxazinanes were obtained in a novel follow-up reaction path. The stability of several 1,2-oxazines and 1,2-oxazinanes towards organometallic compounds was tested to rate their operability as cyclic chiral Weinreb amide auxiliaries. 3,6-Di-tert-butyl-1,2-oxazinane gave the best results and was introduced as a chiral Weinreb amide-type auxiliary to yield chiral α-substituted ketones in a diastereomeric ratio of up to 98:2. The removal of the auxiliary can be performed with BuLi to form unsymmetrical α-chiral ketones. Thereafter, the chiral auxiliary can be re-isolated and purified by sublimation under vacuum.
Nutrition Phytochemicals Affecting Platelet Signaling and Responsiveness: Implications for Thrombosis and Hemostasis
Authors: Tamer Funda , Tullemans Bibian M. E. , Kuijpers Marijke J. E. , Claushuis Theodora A.M. , Heemskerk Johan W. M. 
Published: October 2021

AbstractCardiovascular disease, in particular due to arterial thrombosis, is a leading cause of mortality and morbidity, with crucial roles of platelets in thrombus formation. For multiple plant-derived phytochemicals found in common dietary components, claims have been made regarding cardiovascular health and antiplatelet activities. Here we present a systematic overview of the published effects of common phytochemicals, applied in vitro or in nutritional intervention studies, on agonist-induced platelet activation properties and platelet signaling pathways. Comparing the phytochemical effects per structural class, we included general phenols: curcuminoids (e.g., curcumin), lignans (honokiol, silybin), phenolic acids (caffeic and chlorogenic acid), derivatives of these (shikimic acid), and stilbenoids (isorhapontigenin, resveratrol). Furthermore, we evaluated the flavonoid polyphenols, including anthocyanidins (delphinidin, malvidin), flavan-3-ols (catechins), flavanones (hesperidin), flavones (apigenin, nobiletin), flavonols (kaempferol, myricetin, quercetin), and isoflavones (daidzein, genistein); and terpenoids including carotenes and limonene; and finally miscellaneous compounds like betalains, indoles, organosulfides (diallyl trisulfide), and phytosterols. We furthermore discuss the implications for selected phytochemicals to interfere in thrombosis and hemostasis, indicating their possible clinical relevance. Lastly, we provide guidance on which compounds are of interest for further platelet-related research.
COVID-19 Pandemic and its Impact on the Management of Head and Neck Cancer in the Spanish Healthcare System.
Authors: Mayo-Yáñez Miguel , Palacios-García José M. , Calvo-Henríquez Christian , Ayad Tareck , Saydy Nadim , León Xavier , Parente Pablo , Chiesa-Estomba Carlos Miguel , Lechien Jérôme R. 
Published: October 2021

Abstract:
Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has represented a major challenge for healthcare systems worldwide, changing the habits of physicians. A reorganization of healthcare activity has been necessary, limiting surgical activity to essential cases (emergencies and oncology), and improving the distribution of health resources.
Objective To analyze the impact of the COVID-19 pandemic on head and neck cancer surgery management in Spain.
Methods A cross-sectional study, through an anonymous and voluntary online survey distributed to 76 Spanish otorhinolaryngology departments.
Results A total of 44 centers completed the survey, 65.9% of which were high-volume. A total of 45.5% of them had to stop high-priority surgery and 54.5% of head and neck surgeons were relocated outside their scope of practice. Surgeons reported not feeling safe during their usual practice, with a decrease to a 25% of airway procedures. A total of 29.5% were “forced” to deviate from the “standard of care” due to the epidemiological situation.
Conclusions Approximately half of the departments decreased their activity, not treating their patients on a regular basis, and surgeons were reassigned to other tasks. It seems necessary that the head and neck surgeons balance infection risk with patient care. The consequences of the reported delays and changes in daily practice should be evaluated in the future in order to understand the real impact of the pandemic on the survival of head and neck cancer patients.
Aceruloplasminemia: MRI and Biochemical Profile Clue to Early Diagnosis in an Adolescent
Authors: Sheth Swapnil , Sud Seema , Buxi Tarvinder B. S. , Bhargava Salil , Puri Ratna Dua , Sandal Sapna , Agrawal C.S. 
Published: October 2021

AbstractAceruloplasminemia (ACP) is a rare autosomal recessive genetic disorder with systemic and brain iron overload, secondary to ceruloplasmin gene mutation, usually presents in adults with neurological manifestations. An abnormal biochemical profile may be the only clue in an adolescent patient, that is, microcytic anemia, low transferrin saturation, hyperferritinemia, and should warrant a possible diagnosis of ACP, which can be established by low serum ceruloplasmin levels and appropriate genetic testing. We present a case of an adolescent patient in whom ACP was suspected when brain magnetic resonance imaging showed iron overload in basal ganglia, thalami, red nuclei, dentate nuclei, and choroid plexus and later on confirmed by biochemical profile. The final diagnosis was confirmed by the presences of a novel mutation on genetic analysis. To the best of our knowledge, our case is the second description of ACP with choroid plexus hemosiderosis.We proposed in this article that the combination of parenchymal and choroid plexus iron overload should prompt the suspicion of ACP.
A physiological model of human mobility: A global study
Authors: Kölbl Robert , Kozek Martin 
Published: October 2021

AbstractThe movement of people has led to several challenges in terms of traffic congestion, energy consumption, emissions and climate change. Human mobility modelling is currently described mainly through socio-economic variables, such as travel time, travel costs, income and car-ownership. The overall objective of this paper is to relate mobility behaviour based on measurable entities of travel time and distance and the entities of speed. A simple underlying mechanism of human mobility is presented based on the human energy expended. The energy is related firstly to the average values of travel modes. Explicit formulas for the distribution within each travel mode are developed and the concept is also shown to apply to multi-modal mobility. The approach is described in its most basic and fundamental form, but opens up perspectives for new applications and analyses approaches to transport modelling, planning and appraisals. The approach shows that travel time and distance are consistently inversely proportional and limited by the physiological power consumption. The basic hypothesis and the related verifications is shown on all modal combinations of daily mobility with a medianR2of around 0.8. The approach is validated using national travel surveys of Germany, Switzerland, UK and US, spanning over five decades to 2018.
MDM2, MDMX, and p73 regulate cell-cycle progression in the absence of wild-type p53
Authors: Klein Alyssa M. , Biderman Lynn , Tong David , Alaghebandan Bita , Plumber Sakina A. , Mueller Helen S. , van Vlimmeren Anne , Katz Chen , Prives Carol 
Published: October 2021

SignificanceThe Murine Double Minute 2–Murine Double Minute X (MDM2–MDMX) heterodimer is well known as one of the major negative regulators of the tumor suppressor p53, but the p53-independent functions of MDM2 and MDMX are not as well studied. Our work demonstrates that MDM2 and MDMX, both independently and as a heterocomplex, are required for cell-cycle progression in cancer cells either expressing certain mutant forms of p53 or lacking p53 expression entirely. MDM2 and MDMX further regulate the expression of p73 and certain E2F family activators, both of which are linked to cell division. The p53-independent activity of MDM2 and MDMX may be a potential therapeutic target in cancers lacking wild-type p53.
Accurate model of liquid–liquid phase behavior of intrinsically disordered proteins from optimization of single-chain properties
Authors: Tesei Giulio , Schulze Thea K. , Crehuet Ramon , Lindorff-Larsen Kresten 
Published: October 2021

Significance
Cells may compartmentalize proteins via a demixing process known as liquid–liquid phase separation (LLPS), which is often driven by intrinsically disordered proteins (IDPs) and regions. Protein condensates arising from LLPS may develop into insoluble protein aggregates, as in neurodegenerative diseases and cancer. Understanding the process of formation, dissolution, and aging of protein condensates requires models that accurately capture the underpinning interactions at the residue level. In this work, we leverage data from biophysical experiments on IDPs in dilute solution to develop a sequence-dependent model which predicts conformational and phase behavior of diverse and unrelated protein sequences with good accuracy. Using the model, we gain insight into the coupling between chain compaction and LLPS propensity.
Flexible complementary circuits operating at sub-0.5 V via hybrid organic–inorganic electrolyte-gated transistors
Authors: Yao Yao , Huang Wei , Chen Jianhua , Wang Gang , Chen Hongming , Zhuang Xinming , Ying Yibin , Ping Jianfeng , Marks Tobin J. , Facchetti Antonio 
Published: October 2021

Significance
Electrolyte-gated transistor (EGT)–based inverter circuits are the basic building blocks of next-generation flexible electronic devices. However, constructing high-performance complementary inverters is challenging due to the unbalanced electrical performances of available p- and n-type EGT semiconducting materials. Here we report high-performance EGT complementary inverters achieved by combining p-type organic electrochemical transistors based on an ion-permeable semiconducting organic polymer and n-type electric double-layer transistors based on an ion-impermeable metal oxide semiconductor. The resulting closely balanced complementary inverters achieve ultrahigh voltage gain (>110) under a low supply voltage of only 0.7 V and have been successfully used to achieve flexible logic circuits and sensitive electrophysiological signal amplification suitable for ophthalmologic diagnostics and measuring eye movement.
Compliments and compliment responses in Egyptian and Saudi Arabic
Authors: El-Dakhs Dina Abdel Salam 
Published: October 2021

Abstract
The current study reports on a variational pragmatic comparison of compliments and compliment responses between
Egyptian and Saudi Arabic. Data were collected by using Discourse Completion Tasks from 443 Egyptian and 428 Saudi undergraduates,
and were analyzed using adaptations of Yuan’s (2002) and Herbert’s (1986) models. The results reveal significant differences in politeness management between
Egyptian and Saudi youth, particularly with Egyptians producing more explicit compliment strategies and Saudis showing stronger
preference for implicit compliment strategies and combination patterns. Less difference is noted in compliment responses with only
Egyptians exhibiting higher use of additional strategies. The findings are interpreted in light of politeness theory and the
interplay between cultural values and linguistic behavior.
High-throughput acoustofluidic microchannels for single cell rotation
Authors: Zhu Junwen , Zhang Qiqian , Liang Fei , Feng Yongxiang , Wang Wenhui 
Published: October 2021

Abstract
There is a growing desire for cell rotation in the field of biophysics, bioengineering and biomedicine. We herein present novel microfluidic channels for simultaneous high-throughput cell self-rotation using local circular streaming generated by ultrasonic wave excited bubble arrays. The bubble traps achieve high homogeneity of liquid–gas interface by setting capillary valves at the entrances of dead-end bubble trappers orthogonal to the main microchannel. In such a highly uniform bubble array, rotation at different fields of bubble-relevant vortices is considered equal and interconvertible. The device is compatible with cells of various size and retains manageable rotation velocity when actuated by signals of varying frequency and voltage. Experimental observations were confirmed consistent with theoretical estimation and numerical simulation. Comparing with conventional approaches (e.g. mechanical contact based, dielectrophoresis, optical tweezers) of cell rotation, our device has multiple merits such as high throughput, low cost and simple fabrication procedure, and high compatibility for lab-on-chip integration. Therefore, the platform holds a promise in cell observation, medicine development and biological detection.
Fringe fields are important when examining molecular orientation in a cold ammonia beam
Authors: Bertier Paul , Heazlewood Brianna R 
Published: October 2021

Abstract
External fields have been widely adopted to control and manipulate the properties of gas-phase molecular species. In particular, electric fields have been shown to focus, filter and decelerate beams of polar molecules. While there are several well-established approaches for controlling the velocity and quantum-state distribution of reactant molecules, very few of these methods have examined the orientation of molecules in the resulting beam. Here we show that a buffer gas cell and three-bend electrostatic guide (coupled to a time-of-flight set-up) can be configured such that 70% of ammonia molecules in the cold molecular beam are oriented to an external electric field at the point of detection. With a minor alteration to the set-up, an approximately statistical distribution of molecular orientation is seen. These observations are explained by simulations of the electric field in the vicinity of the mesh separating the quadrupole guide and the repeller plate. The combined experimental apparatus therefore offers control over three key properties of a molecular beam: the rotational state distribution, the beam velocity, and the molecular orientation. Exerting this level of control over the properties of a molecular beam opens up exciting prospects for our ability to understand what role each parameter plays in reaction studies.
Anomalous dependence of ionization probability and electron angular distributions on orientation of molecular axis in photoionization of

H2+

: effect of two-center interference
Authors: Krapivin Dmitry A , Telnov Dmitry A 
Published: October 2021

Abstract
A theoretical and computational study of photoionization of the one-electron molecular ion

H

2

+

initially in the 1σ

u
state is performed. The laser pulse is linearly polarized with the carrier wavelength in the extreme ultraviolet and soft x-ray regions. The electron wave function is obtained by solving the time-dependent Schrödinger equation with the help of the generalized pseudospectral method. The dependence of the total ionization probability and photoelectron spectra on the orientation of the molecular axis is analyzed. Within the wavelength interval 6 to 23 nm, anomalous behavior of the ionization probability is found, where it increases with the angle between the polarization vector of the external field and the molecular axis and reaches a maximum at the perpendicular orientation of the molecule. The phenomenon is explained as resulting from the two-center interference in the wave function of the emitted electron.
Defect concentration and Δn change in light- and elevated temperature-induced degradation
Authors: Kim Moonyong , Wright Matthew , Chen Daniel , Chan Catherine , Ciesla Alison , Abbott Malcolm , Hallam Brett 
Published: October 2021

Abstract
The wide variety of silicon materials used by various groups to investigate LeTID make it difficult to directly compare the defect concentrations (N
t) using the typical normalised defect density (NDD) metric. Here, we propose a new formulation for a relative defect concentration (β) as a correction for NDD that allows flexibility to perform lifetime analysis at arbitrary injection levels (Δn), away from the required ratio between Δn and the background doping density (N
dop) for NDD of Δn/N
dop = 0.1. As such, β allows for a meaningful comparison of the maximum degradation extent between different samples in different studies and also gives a more accurate representative value to estimate the defect concentration. It also allows an extraction at the cross-over point in the undesirable presence of iron or flexibility to reduce the impact of modulation in surface passivation. Although the accurate determination of β at a given Δn requires knowledge of the capture cross-section ratio (k), the injection-independent property of the β formulation allows a self-consistent determination of k. Experimental verification is also demonstrated for boron-oxygen related defects and LeTID defects, yielding k-values of 10.6 ± 3.2 and 30.7 ± 4.0, respectively, which are within the ranges reported in the literature. With this, when extracting the defect density at different Δn ranging between 1014 cm−3 to 1015 cm−3 with N
dop = 9.1 × 1015 cm−3, the error is less than 12% using β, allowing for a greatly improved understanding of the defect concentration in a material.
Resonant precession of magnetization and precession—induced DC voltages in FeGaB thin films
Authors: Bajracharya Prabesh , Sharma Vinay , Johnson Anthony , Budhani Ramesh C 
Published: October 2021

Abstract
Measurements of frequency dependent ferromagnetic resonance and spin pumping driven dc voltage (V
dc) are reported for amorphous films of Fe78Ga13B9 alloy to address the phenomenon of self-induced inverse spin Hall effect (ISHE) in plain films of metallic ferromagnets (FMs). The V
dc signal, which is anti-symmetric on field reversal, comprises of symmetric and asymmetric Lorentzians centered around the resonance field. Dominant role of thin film size effects is seen in setting the magnitude of static magnetization, V
dc and dynamics of magnetization precession in thinner films (⩽8 nm). The film thickness dependence of magnetization parameters indicates the presence of a magnetically disordered region at the film—substrate interface, which may promote preferential flow of spins generated by the precessing magnetization towards the substrate. However, the V
dc signal also draws contributions from rectification effects of a ≈0.4% anisotropic magnetoresistance and a large (≈54 nΩ m) anomalous Hall resistivity (AHR) of these films which ride over the effect of spin–orbit coupling driven spin-to-charge conversion near the film—substrate interface. We have addressed these data in the framework of the existing theories of electrodynamics of a ferromagnetic film subjected to radio-frequency field in a coplanar waveguide geometry. Our estimation of the self-induced ISHE for the sample with 54 nΩ m AHR shows that it may contribute significantly (≈90%) to the measured symmetric voltage. This study is expected to be very useful for fully understanding the spin pumping induced dc voltages in metallic FMs with disordered interfaces and large anomalous Hall effect.