bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical Profiling and Bioactivities of Pelargonium graveolens Essential Oil against Spodoptera littoralis (Lepidoptera: Noctuidae)1
Authors: Alkherb Wafa Abdullah Hamad 
Published: December 2024

Abstract
Scientists are searching for safer substitutes for several hazardous chemicals because of environmental concerns and the development of arthropod resistance to synthetic pesticides. Essential oils pose fewer risks to the environment and human health and are potential alternatives for crop protection; therefore, this study assessed the toxicity and biochemical activity of essential oils from geranium (Pelargonium graveolens L’Hérit) against larvae of Spodoptera littoralis (Boisduval) (Lepidoptera: Noctuidae). In addition, molecular docking was used to determine the binding pattern of the detoxifying enzymes glutathione S-transferase (GST), cytochrome P450, and α-esterase with citronellol, the main ingredient (20.91%) of the P. graveolens extract. Concentration–mortality response assays determined lethal concentrations (LCs) of the essential oil as LC15 = 608.52 mg/L and LC50 = 1,820.77 mg/L against second-instar larvae. Additional sublethal studies showed that, compared with the control, exposure of the second-instar larvae with LC15 or LC50 levels of P. graveolens essential oil significantly increased the duration of the larval and pupal stages. Considerable biochemical alterations were found in relation to P. graveolens essential oil biochemical impact on S. littoralis larvae. According to the activity of detoxifying enzymes and the results of the molecular docking study, the citronellol molecule of P. graveolens essential oil exhibited a binding affinity of GST &gt; cytochrome P450 &gt; α-esterase, with an energy score of −5.346, −5.295, and −5.4278 kcal/mol, respectively. The findings confirm the potential of using essential oils in sustainable pest management.
Параметри стрічкового електронного пучка, сформованого гарматами ВТР: дослідження положення плазмової межі
Authors: Мельник Ігор Віталійович , Тугай Сергій Борисович , Коваленко Олександр Миколайович , Скрипка Михайло Юрійович 
Published: December 2024

У першій частині статті отримані аналітичні співвідношення для розрахунку положення плазмової межі відносно поверхні катода в електродній системі високовольтного тліючого розряду, яка формує стрічковий електронний пучок з лінійним фокусом. Проведені розрахунки ґрунтуються на припущені, що в системах з різною геометрією електродів анодна плазма, за умови однакової прискорювальної напруги та однакового тиску, займає однаковий об’єм. Наведені отримані в результаті моделювання графічні залежності положення плазмової межі від прискорювальної напруги та тиску газу. Проведені теоретичні та експериментальні дослідження показали, що розрахункові дані для положення плазмової межі відносно катоду, у разі середніх та великих значень тиску в камері газорозрядної гармати, відрізняються від експериментальних даних не більше, ніж на 5 – 10 %.
Враховуючи те, що в електродних системах високовольтного тліючого розряду анодна плазма є джерелом іонів та електродом з потенціалом, з використанням методів комп’ютерного моделювання можуть бути визначені розподіл електричного поля та фокальні параметри стрічкового електронного пучка з лінійним фокусом.
Генерація електромагнітних хвиль на основі ефектів взаємодії заряджених частинок, що рухаються, з полями, збуджувальних ними власних мод хвилевідних та резонаторних структур
Authors: Прокопенко Юрій Володимирович , Аверков Юрій Олегович , Дормідонтов Анатолій Вікторович 
Published: December 2024

В статті наведено огляд наукових робіт авторів, які є подальшим розвитком наукових напрямів НВЧ- та ВВЧ-електроніки, які одним із перших розвивав професор В. П. Тараненко. Продемонстровано можливість поширення слабозагасаючих електромагнітних хвиль у надрозмірних електродинамічних твердотільних структурах, в тому числі, що містять плазмоподібне середовище. Приділено увагу механізмам збудження власних хвиль та коливань таких структур, які базуються на ефекті Вавілова–Черенкова, аномальному ефекті Доплера чи перехідному випромінювані. Продемонстровано генерацію електромагнітного випромінювання у разі взаємодії потоків заряджених частинок з полями власних хвиль чи коливань таких структур. Показано можливість освоєння міліметрового та субміліметрового діапазонів довжин хвиль із застосуванням багатомодових електродинамічних структур з прийнятними розмірами для виробництва. Представлено електродинамічні системи на надкритичному струмі релятивістського електронного пучка — віртод та віртод–ЛЗХ, в яких реалізовано керування амплітудно-частотними характеристиками НВЧ-випромінювання.
Pelatihan Public Speaking dan Personal Branding untuk Membangun Karakter Kepemimpinan Siswa OSIS SMA Angkasa 1 Halim Perdanakusuma Jakarta
Authors: Andika Yunilis Andika , Wahyu Tri Widyastuti  , Al Farisi Salman 
Published: December 2024

Public speaking and personal branding are essential skills that can open career opportunities and advance professional development for everyone, especially OSIS students. SMA Angkasa 1 Halim Perdanakusuma recognizes the importance of these skills for its students. Unfortunately, specialized training related to these topics has not yet been conducted there. To address this issue, the Community Service team from the French Language Education Program collaborated with SMA Angkasa 1 Halim Perdanakusuma to organize training in public speaking and personal branding aimed at developing the leadership character of OSIS students. This activity was conducted in-person and comprised three stages: preparation, implementation, and evaluation. A total of 33 students participated in this event, receiving both theoretical and practical instruction, along with assignments to enhance their public speaking skills and build a positive self-image. The results of the training showed positive development after the sessions, with participants demonstrating increased confidence and the ability to present material effectively using various public speaking techniques.

Abstrak
Public speaking dan personal branding adalah keterampilan penting yang dapat membuka peluang karir dan memajukan perkembangan profesional bagi setiap orang, terutama siswa OSIS. SMA Angkasa 1 Halim Perdanakusuma menyadari pentingnya keterampilan tersebut bagi siswanya. Sayangnya, pelatihan khusus terkait tema tersebut belum pernah dilaksanakan di sana. Untuk mengatasi permasalahan tersebut, tim Pengabdian Kepada Masyarakat Prodi Pendidikan Bahasa Prancis bekerja sama dengan SMA Angkasa 1 Halim Perdanakusuma dalam mengadakan pelatihan public speaking dan personal branding dengan tujuan mengembangkan karakter kepemimpinan siswa OSIS. Kegiatan ini dilaksanakan secara luring dengan tiga tahapan yakni persiapan, pelaksanaan, dan evaluasi. Sebanyak 33 siswa menjadi peserta pada kegiatan ini dengan diberikan teori dan praktik, serta penugasan untuk meningkatkan keterampilan berbicara di depan umum dan membangun citra diri yang positif. Hasil pelatihan menunjukkan perkembangan yang positif setelah pelatihan di mana peserta memiliki kepercayaan diri yang meningkat sehingga mampu menyampaikan materi dengan baik dengan menerapkan berbagai teknik public speaking.
Successful Reduction of a Dislocated Hip Joint in a Patient With Cutis Laxa From a PYCR1 Mutation
Authors: Samarah O.Q. , Abu Rumman D.H. , Ibrahim S.J. , Hamed E.K. , Obeidat D.M. 
Published: December 2024

Case:
We report a successful surgical management of a teratologic hip dislocation in a 2.5-year-old girl child with cutis laxa and a positive PYCR1 gene mutation. She had characteristic facial features including triangular face with frontal bossing. Moreover, she had wrinkly skin on her limbs. At 2-year follow-up, she became an independent ambulator with stable hip joint and mild limping.

Conclusion:
The surgical principles of treating a high riding hip dislocation in patients with positive PYCR1 gene mutation should be comprehensive including open reduction, pelvic osteotomy, and femoral shortening osteotomy with derotation. Meticulous capsulorrhaphy optimizes the development and stability of the hip joint.
IMPLEMENTASI KURIKULUM MERDEKA PADA PEMBELAJARAN PAI DI JENJANG SEKOLAH MENENGAH PERTAMA
Authors: Izza Aimatul , Astutik Anita Puji 
Published: December 2024

Tujuan pendalaman ini merupakan untuk menganalisis implementasi silabus merdeka belajar dalam pengkajian agama islam ( PAI ) pada jenjang sekolah menengah pertama ( SMP ). Kurikulum Merdeka Belajar ( KMB ) yaitu upaya pemerintah untuk meroformasikan pembelajaran di indonesia dengan membagikan kelonggaran kepada sekolah untuk meningkatkan kurikulum yang sesuai dengan kebutuhan peserta didik. Pendalaman ini memakai cara pendalaman kualitatif dengan pendekatan studi kasus, data disatukan melewati pengamatan, wawancara, dan dokumentasi terkait kurikulum dan pembelajaran. Responden penelitian ini terdiri dari pengajar pengkajian agama islam ( PAI ) di sekolah menengah pertama ( SMP ) Islam Sidoarjo yang mengimplementasikan silabus merdeka belajar. Hasil penyelidikan membagikan bahwa ini program silabus merdeka belajar untuk studi agama islam ( PAI ) di sekolah menengah pertama ( SMP ) Islam Sidoarjo mempunyai beberapa keuntungan. Pertama, pengajar dapat menyesuaikan taktik pengkajian dengan gaya belajar siswa, sehingga mengembangkan keterlibatan dan pemahaman mereka. Kedua, pengajar dapat memilih bahan yang sesuai dengan kebutuhan siswa serta keadaan setempat, mengembangkan makna pendidikan. Ketiga, pengajar mempunyai kebebasan untuk menilai kemajuan peserta didik dengan menggunakan cara penilaian yang sesuai dengan sifat dan kebutuhan siswa.
AKUNTABILITAS PENGELOLAAN ANGGARAN DALAM PERSPEKTIF MAQASHID SHARIAH PADA DINAS SYARIAT ISLAM KABUPATEN PIDIE JAYA
Authors: Ramadhana Rizki , Albani Nasution Muhammad Syukri , Batubara Maryam 
Published: December 2024

Tujuan Untuk mengetahui pengelolaan anggaran pada Dinas Syariat Islam Kabupaten Pidie Jaya, Untuk mengetahui model akuntabilitas pengelolaan anggaran pada Dinas Syariat Islam Kabupaten Pidie Jaya. Penelitian ini merupakan penelitian dengan menggunakan pendekatan kualitatif deskriptif dengan menggunakan pendekatan studi kasus. Dalam penelitian ini digunakan studi dokumenter, wawancara, observasi . Adapun Hasil penelitian sebagai berikut, Secara keseluruhan pengelolaan anggaran pada Dinas Syariat Islam Kabupaten Pidie Jaya telah terkelola dengan baik melalui prinsip perencanaan, pengorganisasian, pelaksanaan dan pengendalian yang melibatkan seluruh pihak yang berkaitan dengan program-program yang dianggarkan oleh Dinas Syariat Islam Kabupaten Pidie Jaya. Setiap melakukan penyusunan program kerja Dinas Syariat Islam Kabupaten Pidie Jaya selalu mengikutsertakan masyarakat dalam menentukan program apa saja yang akan dilakukan oleh instansi. Model akuntabilitas anggaran pada Dinas Syariat Islam Kabupaten Pidie Jaya berfokus pada output dan outcome yang diperoleh, dimulai dari input yang berupa bukti-bukti transaksi keuangan maupun dokumentasi kegiatan yang selanjutnya diproses untuk menyusun laporan akuntabilitas. Proses akuntabilitas yang dilakukan dengan menyusun, mengklasifikasi, mengikhtisarkan, dan menyajikan bukti-bukti transaksi yang menjadi input dalam uraian laporan akuntabilitas. Output yang dihasilkan adalah Laporan Akuntabilitas yang disusun, dan Outcome yang dihasilkan adalah kinerja pelaksanaan anggaran sesuai dengan yang dialokasikan dan kepercayaan para stakeholder. Namun pada praktiknya terkadang terdapat kendala pada keterlambatan pelaporan pertanggungjawaban karena adanya dokumen yang tidak lengkap dari bidang-bidang atau dari para stakeholder yang lain. Secara umum akuntabilitas anggaran yang dilakukan oleh Dinas Syariat Islam Kabupaten Pidie Jaya telah memenuhi lima tujuan dalam konsep maqashid shariah yaitu hifdz ad-din, hifdz an-nas, hifdz al-aql, hifdz al-mal, dan hifdz an-nasb. Hanya saja, Dinas Syariat Islam perlu melakukan evaluasi sebagai perbaikan ke depan dalam pengalokasian anggaran pada program-program atau kegiatan-kegiatan yang mempunyai urgensi lebih dibanding dengan program kegiatan lainnya.
Impact of LIN7A Silencing on U87 Cell Invasion and Its Clinical Significance in Glioblastoma
Authors: Lyu Xiaojuan , Shi Yuxiang , Wang Daixu , Cao Xing , Guo Jipeng , Huang Guodong , Zhou Lin , Zhang Mengxian , Dong Zhen 
Published: December 2024

Abstract

Background Glioblastoma is highly aggressive and resistant to treatment, making it crucial to understand the regulatory mechanisms underlying its invasion. LIN7A, a polar protein, has been implicated in tumor cell migration and invasion, but its role in glioblastoma remains unclear. This study aimed to manipulate LIN7A gene expression in U87 cells, analyze its impact on invasion, and explore the potential mechanisms through which LIN7A regulates glioblastoma cell invasion.Methods Lentiviral vectors were used to silence the LIN7A gene in U87 cells, selecting the most effective vector. LIN7A gene transcription, protein expression and localization were analyzed using RT-qPCR, Western blotting, and immunofluorescence. U87 cell invasion was assessed via real-time cell analysis and spheroid invasion assay, while MMP-2 and MMP-9 protease activities were measured using zymography. β-catenin protein levels and localization were evaluated through Western blotting and immunofluorescence. Expression of target genes in the β-catenin pathway was also measured. An orthotopic xenograft glioblastoma model in nude mice was established by intracranial implantation of U87 cells, with tumor growth monitored using immunofluorescence analysis of brain slices. The clinical significance of LIN7A expression was confirmed by comparing its levels in core and peripheral invading areas of glioblastoma and analyzing RNASeq data and clinical information from the Clinical Proteomic Tumor Analysis Consortium (CPTAC) GBM cohort.Results Transfection of U87 cells with a lentiviral vector led to decreased LIN7A levels and altered distribution patterns. Silencing the LIN7A gene increased U87 cell proliferation and invasiveness, reduced clonal formation ability, and enhanced MMP-2 and MMP-9 protease activity. It also resulted in a slight increase in cytoplasmic β-catenin content, although not statistically significant, but a significant increase in nuclear β-catenin accumulation and transcriptional activity of target genes in the pathway. Animal studies showed that LIN7A gene silencing caused U87 cells to transition from clumpy to invasive growth mode. LIN7A expression was significantly lower in the peripheral invading area compared to the core area in clinical samples of glioblastoma. Data mining of the CPTAC-GBM cohort revealed a strong association between LIN7A gene expression and survival time.Conclusion Silencing LIN7A may promote U87 tumor cell invasion by disrupting intercellular junctions, altering cell polarity, and activating the β-catenin pathway. Further research is warranted to elucidate the role of LIN7A in glioblastoma cell invasion.
Abnormal Redox Balance at Membrane Contact Sites Causes Axonopathy in Gdap1-related Charcot-marie-tooth Disease
Authors: Palau Francesc , Cantarero Lara , Roldán Mónica , Rodríguez-Sanz María , Mathison Angela , Díaz-Osorio Yaiza , Pijuan Jordi , Frías Marcos , Urrutia Raul , Hoenicka Janet 
Published: December 2024

Abstract

Pathogenic variants of GDAP1 cause Charcot-Marie-Tooth disease (CMT), an inherited neuropathy characterized by axonal degeneration. GDAP1, an atypical glutathione S-transferase, localizes to the outer mitochondrial membrane (OMM), regulating this organelle's dynamics, transport, and membrane contact sites (MCSs). It has been proposed that GDAP1 functions as a cellular redox sensor. However, its precise contribution to redox homeostasis remains poorly understood, as does the possible redox regulation at mitochondrial MCSs. Given the relationship between the peroxisomal redox state and overall cellular redox balance, we investigated the role of GDAP1 in peroxisomal function and mitochondrial MCSs maintenance by using high-resolution microscopy, live cell imaging with pH-sensitive fluorescent probes, and transcriptomic and lipidomic analyses in the Gdap1-/- mice and patient-derived fibroblasts.
We demonstrate that GDAP1 deficiency disrupts mitochondria-peroxisome MCSs and leads to peroxisomal abnormalities, which are reversible upon pharmacological activation of PPARγ or glutathione supplementation. These results identify GDAP1 as a new tether of mitochondria-peroxisome MCSs that maintain peroxisomal number and integrity. The supply of glutathione (GSH-MEE) or GDAP1 overexpression suffices to rescue these MCSs. Furthermore, GDAP1 may regulate the redox state within the microdomain of mitochondrial MCSs, as suggested by decreased pH at mitochondria-lysosome contacts in patient-derived fibroblasts, highlighting the relationship between GDAP1 and redox-sensitive targets.
Finally, in vivo analysis of sciatic nerve tissue in Gdap1-/- mice revealed significant axonal structural abnormalities, including nodes of Ranvier disruption and defects in the distribution and morphology of mitochondria, lysosomes, and peroxisomes, emphasizing the importance of GDAP1 in sustaining axon integrity in the peripheral nervous system. Taken together, this study positions GDAP1 as a multifunctional protein that mediates mitochondrial interaction with cellular organelles of diverse functions, contributes to redox state sensing, and helps maintain axonal homeostasis. In addition, we identify PPAR as a novel therapeutic target, based on knowledge of the underlying pathogenetic mechanisms.
Insights from LLIN Post-Distribution Monitoring Surveys in the Dominican Republic's Malaria Transmission Foci: Implications for Quantification and Distribution Strategies
Authors: Ventura Gilda Altagracia , Santos María Yinet , Tejada Natalia , Michelen Nicole , Cruz Jose Luis , Solis Angel , Barrios Rafael , Montoya Lucia Fernández 
Published: December 2024

Abstract

Background: Long-lasting insecticidal nets (LLINs) have been distributed in the Dominican Republic since 2008, and they remain the main vector control intervention used to pursue malaria elimination in the country. However, LLIN performance remains unclear due to a lack of monitoring over the past decade.
Methods: We conducted a cross-sectional household survey to monitor LLIN coverage, access, use, physical integrity, washing and drying practices and the time people go to bed and wake up in the two main malaria foci of the country: Azua (4-6 months post distribution) and San Juan (one year post distribution).
Results: The percentage of sleeping spaces that could be covered with an LLIN given the LLINs present in the household was 64% in Azua and 63% in San Juan, and with any net they were 75% in Azua and 80% in San Juan. Reported LLIN retention was 88.4% in Azua and 80.9% in San Juan. The percentage of people that had access to sleeping under an LLIN was 58.8% in Azua and 65.4% in San Juan. LLIN use was 32.3% in Azua and 50.5% in San Juan. Among people with full LLIN access, use was 48.8% in Azua and 75% in San Juan. Most LLINs remained in serviceable physical condition (96.4%, 88.9%) but those with holes were not repaired. Most LLINs were washed with aggressive products (65%, 86%), at a frequency that suggests they will be washed more than twenty times in three years (52%, 73%), and dried under the sun (75%, 90%).
Conclusion: Poor washing and drying practices are prevalent in both areas, low LLIN use was observed in Azua and some LLIN coverage gaps were measured in both foci. Urgent behavioral change strategies are needed to improve LLIN care in both foci and increase LLIN use in Azua, alongside revisions to LLIN quantification methods to ensure full coverage of all sleeping spaces in use during distribution. Heterogeneities in LLINs use across foci suggest that LLIN need to be monitored in each distinct distribution area to identify individual gaps and promptly address them.
Mechanochemical Synthesis of Yttrium Oxide and Hydrogen Peroxide via Planetary Ball Milling With Nickel Catalyst: Structural, Morphological, and Particle Size Analysis
Authors: Pramono Andika Widya , Ansari Mohamed , Sagutnam Meenaloshini a/p , Saputra M. Nuraliffudin , Siregar Riki Ruli A. , Herbirowo Satrio , Holifah  , Miati  , Imaduddin Agung , Nugraha Heri , Hadiyawarman  , Rois Mahardika F. , Sulistiyo Eko , Murniati Riri , Amaliyah Fina Fitratun 
Published: December 2024

Abstract

This study investigates the mechanochemical synthesis of Yttrium Oxide (Y₂O₃) and Hydrogen Peroxide (H₂O₂) via planetary ball milling, with a focus on the catalytic effect of nickel. Yttrium Hydride (YH₃) was milled under a hydrogen atmosphere, both with and without a nickel catalyst, to assess the influence of various process parameters such as milling time, hydrogen pressure, and catalyst presence on the phase transformation, crystallite size, particle morphology, and particle size distribution. X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and laser diffraction particle size analysis (PSA) were used to characterize the samples. Results show that nickel catalysis significantly enhances reaction kinetics, reduces crystallite size, and promotes uniform particle morphology compared to non-catalyzed samples. Catalyzed samples exhibited faster phase transformation from YH₃ to Y₂O₃, with a crystallite size reduction to 11.0 nm and near-complete formation of Y₂O₃ and H₂O₂. These findings demonstrate that nickel-catalyzed planetary ball milling offers an efficient and scalable route for Y₂O₃ synthesis, with potential applications in catalysis, energy storage, and environmental remediation. Further research on optimizing milling conditions and exploring other catalysts is recommended.
Challenges in Implementing the Information Gap Technique to Enhance the Indonesian EFL Students' Speaking Skills
Authors: Pinilih Murni Sekar , Sukarno Sukarno 
Published: December 2024

Even though the Independent Curriculum suggests teachers conduct speaking activities in class, the real situation is quite the opposite. Students rarely speak English in class; hence, students still lack the ability to speak English. This study aims to describe the challenges in implementing the Information Gap Technique to enhance students' speaking skills in a vocational high school located in Sleman. Employing Classroom Action Research, the research unfolds across four iterative stages: planning, action, observation, and reflection. This study used interviews, observations, and documentation as primary instruments. This is qualitative analysis with interactive model analysis and thematic analysis as data analysis. The findings illuminate several hurdles faced by both teachers and students. Teachers confront difficulties in classroom management, struggling to monitor and assess students simultaneously. Meanwhile, students encounter challenges in peer assessment and formulating questions, along with linguistic obstacles in pronunciation and grammar. The study concludes that an effective strategy to mitigate these challenges involves teachers actively circulating the classroom and engaging in peer assessment. This approach enables teachers to identify and address individual student difficulties promptly. The research suggests that while IGT proves effective in enhancing speaking skills and boosting confidence, teachers should judiciously incorporate it, considering both its advantages and drawbacks. The recommendation encourages periodic utilisation of the technique, with teachers being mindful of the need for a balanced approach that addresses the identified challenges, thereby maximising the benefits of IGT in enhancing students' speaking abilities.