bluuebunny/crossref_metadata_2025_split huggingface dataset:
Offspring Educational Attainment and Older Parents' Cognition in Mexico
Authors: Ma Mingming , Yahirun Jenjira , Saenz Joseph , Sheehan Connor 
Published: January 2021

Abstract
Population-level disparities in later-life cognitive health point to the importance of family resources. Although the bulk of prior work on the topic has established the directional flow of resources from parents to offspring, the linked lives perspective raises the question of how offspring resources could affect parental health as well. This study examines whether adult children's education influences older parents' (aged 50+) cognitive health in Mexico, where schooling reforms have contributed to significant gains in the educational achievements of recent birth cohorts. Harnessing a change in compulsory school laws and applying an instrumental variables approach, we found that each year of offspring schooling was associated with higher overall cognition among parents but was less predictive across different cognitive functioning domains. More offspring schooling improved parents' cognitive abilities in verbal learning, verbal fluency, and orientation, but not in visual scanning, visuospatial ability, or visual memory. The beneficial effects of offspring schooling on those cognitive domains are more salient for mothers than for fathers, suggesting potential gendered effects in the influence of offspring schooling. The results remained robust to controls for parent-child contact and geographic proximity, suggesting other avenues through which offspring education could affect parental health and a pathway for future research. Our findings contribute to growing research stressing the causal influence of familial educational attainment on population health.
Cross-Sectional Average Length of Life Childless
Authors: Mogi Ryohei , Nisén Jessica , Canudas-Romo Vladimir 
Published: January 2021

AbstractIncreases in the average age at first birth and in the proportion of women remaining childless have extended the total number of years that women spend childless during their reproductive lifetime in several countries. To quantify the number of years that reproductive-age women live without children, we introduce the cross-sectional average length of life childless (CALC). This measure includes all the age-specific first-birth information available for the cohorts present at time t; it is a period measure based on cohort data. Using the Human Fertility Database, CALC is calculated for the year 2015 for all countries with long enough histories of fertility available. Results show that women in the majority of the studied countries spend, on average, more than half of their reproductive lives childless. Furthermore, the difference between CALCs in two countries can be decomposed to give a clear visualization of how each cohort contributes to the difference in the duration of the length of childless life in those populations. Our illustration of the decomposition shows that (1) in recent years, female cohorts in Japan and Spain at increasingly younger ages have been contributing to more years of childless life compared with those in Sweden, (2) the United States continues to represent an exception among the high-income countries with a low expectation for childless life of women, and (3) Hungary experienced a strong period effect of the recent Great Recession. These examples show that CALC and its decomposition can provide insights into first-birth patterns.
Genetic background modifies vulnerability to glaucoma-related phenotypes in Lmx1b mutant mice
Authors: Tolman Nicholas G. , Balasubramanian Revathi , Macalinao Danilo G. , Kearney Alison L. , MacNicoll Katharine H. , Montgomery Christa L. , de Vries Wilhelmine N. , Jackson Ian J. , Cross Sally H. , Kizhatil Krishnakumar , Nair K. Saidas , John Simon W. M. 
Published: January 2021

ABSTRACT
Variants in the LIM homeobox transcription factor 1-beta (LMX1B) gene predispose individuals to elevated intraocular pressure (IOP), a key risk factor for glaucoma. However, the effect of LMX1B mutations varies widely between individuals. To better understand the mechanisms underlying LMX1B-related phenotypes and individual differences, we backcrossed the Lmx1bV265D (also known as Lmx1bIcst) allele onto the C57BL/6J (B6), 129/Sj (129), C3A/BLiA-Pde6b+/J (C3H) and DBA/2J-Gpnmb+ (D2-G) mouse strain backgrounds. Strain background had a significant effect on the onset and severity of ocular phenotypes in Lmx1bV265D/+ mutant mice. Mice of the B6 background were the most susceptible to developing abnormal IOP distribution, severe anterior segment developmental anomalies (including malformed eccentric pupils, iridocorneal strands and corneal abnormalities) and glaucomatous nerve damage. By contrast, Lmx1bV265D mice of the 129 background were the most resistant to developing anterior segment abnormalities, had less severe IOP elevation than B6 mutants at young ages and showed no detectable nerve damage. To identify genetic modifiers of susceptibility to Lmx1bV265D-induced glaucoma-associated phenotypes, we performed a mapping cross between mice of the B6 (susceptible) and 129 (resistant) backgrounds. We identified a modifier locus on Chromosome 18, with the 129 allele(s) substantially lessening severity of ocular phenotypes, as confirmed by congenic analysis. By demonstrating a clear effect of genetic background in modulating Lmx1b-induced phenotypes, providing a panel of strains with different phenotypic severities and identifying a modifier locus, this study lays a foundation for better understanding the roles of LMX1B in glaucoma with the goal of developing new treatments.
Omega-3 fatty acids accelerate fledging in an avian marine predator: a potential role of cognition
Authors: Lamarre Jessika , Cheema Sukhinder Kaur , Robertson Gregory J. , Wilson David R. 
Published: January 2021

ABSTRACT
Consuming omega-3 fatty acids (n-3 LCPUFAs) during development improves cognition in mammals, but the effect remains untested in other taxa. In aquatic ecosystems, n-3 LCPUFAs are produced by phytoplankton and bioaccumulate in the food web. Alarmingly, the warming and acidification of aquatic systems caused by climate change impair n-3 LCPUFA production, with an anticipated decrease of 80% by the year 2100. We tested whether n-3 LCPUFA consumption affects the physiology, morphology, behaviour and cognition of the chicks of a top marine predator, the ring-billed gull. Using a colony with little access to n-3 LCPUFAs, we supplemented siblings from 22 fenced nests with contrasting treatments from hatching until fledging; one sibling received n-3 LCPUFA-rich fish oil and the other, a control sucrose solution without n-3 LCPUFAs. Halfway through the nestling period, half the chicks receiving fish oil were switched to the sucrose solution to test whether n-3 LCPUFA intake remains crucial past the main growth phase (chronic versus transient treatments). Upon fledging, n-3 LCPUFAs were elevated in the blood and brains of chicks receiving the chronic treatment, but were comparable to control levels among those receiving the transient treatment. Across the entire sample, chicks with elevated n-3 LCPUFAs in their tissues fledged earlier despite their morphology and activity levels being unrelated to fledging age. Fledging required chicks to escape fences encircling their nest. We therefore interpret fledging age as a possible indicator of cognition, with chicks with improved cognition fledging earlier. These results provide insight into whether declining dietary n-3 LCPUFAs will compromise top predators' problem-solving skills, and thus their ability to survive in a rapidly changing world.
Epidemiological, humanistic and economic burden of dog-mediated rabies in India: a systematic review protocol
Authors: John Denny , Royal Abhishek , Bharti Omesh 
Published: January 2021

Background: Rabies is a neglected zoonotic disease. It is transmitted through the bite of a rabid animal and dog bites are responsible for around 95% of human cases. The disease is almost fatal after the onset of symptoms. It is an endemic and major public health problem in India with one-third of the global deaths reported from this country. Protocol: This systematic review aims to estimate the epidemiological, humanistic and economic burden of dog-mediated rabies in India. Initially the existence of controlled descriptors in MeSH terms (such as 'Epidemiology', 'Rabies', 'Cost', 'Dog bite', 'Quality of Life', 'India' etc), and their synonyms (key words) was identified in MEDLINE, and were later combined with Boolean operators 'AND' and 'OR' to develop a detailed search strategy. Two independent reviewers will screen the titles and abstracts and select the studies as per the inclusion criteria. The selected studies will be assessed for their quality and risk of bias. Data will be extracted using standardized data extraction tools and will be synthesized for analysis. Disagreements that arise between the reviewers will be resolved through discussion, or with a third reviewer. Discussion: This systematic review will be performed to critically examine relevant literature and report the epidemiological, humanistic and economic burden of dog-mediated rabies in Indian context. The findings will help in estimation of burden of the disease in India and expected to contribute in policy making and planning of the program and interventions in the country. Protocol registration: PROSPERO ID: CRD4202021326
Children and young people's experiences of living with developmental coordination disorder/dyspraxia: study protocol for a qualitative evidence synthesis
Authors: O'Dea Áine , Coote Susan , Robinson Katie 
Published: January 2021

Background Children with developmental coordination disorder (DCD) face significant challenges to deal with everyday activities due to underlying motor proficiency difficulties. These challenges affect children and young people’s participation; that is, involvement in daily life situations. Recent years have seen a growing body of qualitative research examining children’s experiences of living with DCD. Meta-ethnographic synthesis offers a rigorous approach to bring together the findings of discrete qualitative studies to be synthesised in order to advance the conceptual understanding of living with DCD, which is not well conceptualised in the literature to date. Conducting a meta-ethnographic synthesis will help to illuminate the meaning of children and young people’s experiences of DCD regarding their involvement in everyday activities and situations. Aim This study aims to systematically review and synthesise qualitative literature regarding children and young people’s experiences and views of everyday life and living with DCD. Methods The method of qualitative evidence synthesis that will be followed in this review is a meta-ethnography. The eMERGe and PRISMA reporting guidelines will be adhered to. Ten databases will be searched; Academic Search Complete, AMED, CINAHL, ERIC, MEDLINE, PsychArticles, PsychInfo, EMBASE, SPORTDiscus, and Web of Science. The Joanna Briggs Institute Checklist will be used by two independent reviewers to appraise all included papers. PROSPERO registration number CRD42019129178 Discussion The findings of this meta-ethnography will endeavour to inform future research, policy and practice. In particular, the results will help to inform the design of future complex interventions to meet the needs of children and young people with DCD. Dissemination will involve the publication of the results in a peer-reviewed journal. Increasingly researchers and policymakers are calling for services to be informed by the perspective and voice of children with DCD. Therefore, a policy brief will be published so that the findings are widely available.
Anticipate study protocol: Baseline profile and care outcomes of patients attending Mater Misericordiae University Hospital with COVID-19 infection
Authors: Avramovic Gordana , McHugh Tina , Connolly Stephen P , Cullen Walter , Lambert John S 
Published: January 2021

Background: While the COVID-19 pandemic is currently impacting on health and social care in Ireland, this impact is most marked in metropolitan Dublin. This is especially the case for the Mater Misericordiae University Hospital (MMUH) in Dublin’s North Inner, which is situated in an area where local socially deprived communities are at high risk of infection and of experiencing adverse outcomes. Aims: To determine baseline characteristics and longer-term care outcomes of COVID-19 patients presenting to / attending the Infectious Diseases Department at MMUH, including the virtual clinic. Methods: Retrospective study: we will retrospectively examine clinical records and extract anonymised data on patient demographics, baseline morbidity and outcomes. Prospective study: we will prospectively examine healthcare outcomes among patients who consent to follow up at two time points (three months, and six months to 12 months after discharge/onset of disease). Two patient groups will be assessed for morbid complications: those hospitalised with COVID infection and those followed-up remotely with confirmed COVID infection. Deliverables: The project will involve collaboration with Ireland’s Health Service Executive (HSE) Clinical Programmes and Ireland East Hospital Group to inform health service policies that will attenuate the adverse impacts of the COVID pandemic on population health. This research protocol will evaluate morbid complications of COVID depending on the severity of the disease.
Implication of backward contact tracing in the presence of overdispersed transmission in COVID-19 outbreaks
Authors: Endo Akira ,   Centre for the Mathematical Modelling of Infectious Diseases COVID-19 Working Group, Leclerc Quentin J. , Knight Gwenan M. , Medley Graham F. , Atkins Katherine E. , Funk Sebastian , Kucharski Adam J. 
Published: January 2021

Introduction: Contact tracing has the potential to control outbreaks without the need for stringent physical distancing policies, e.g. civil lockdowns. Unlike forward contact tracing, backward contact tracing identifies the source of newly detected cases. This approach is particularly valuable when there is high individual-level variation in the number of secondary transmissions (overdispersion). Methods: By using a simple branching process model, we explored the potential of combining backward contact tracing with more conventional forward contact tracing for control of COVID-19. We estimated the typical size of clusters that can be reached by backward tracing and simulated the incremental effectiveness of combining backward tracing with conventional forward tracing. Results: Across ranges of parameter values consistent with dynamics of SARS-CoV-2, backward tracing is expected to identify a primary case generating 3-10 times more infections than a randomly chosen case, typically increasing the proportion of subsequent cases averted by a factor of 2-3. The estimated number of cases averted by backward tracing became greater with a higher degree of overdispersion. Conclusion: Backward contact tracing can be an effective tool for outbreak control, especially in the presence of overdispersion as is observed with SARS-CoV-2.
COCON – Swiss Longitudinal Survey of Children and Youth
Authors: Buchmann Marlis , Grütter Jeanine , Igel Corinne 
Published: January 2021

This study profile describes COCON – the acronym for COmpetence and CONtext. This is an interdisciplinary, multi-cohort and multi-informant longitudinal study with a primary focus on how children and adolescents cope with the developmental tasks of early life course transitions. It strives to detect the social and individual antecedents and consequences associated with the handling of these transitions. The project frames child and adolescent development in the triple theoretical perspective of challenges imposed by early transitions in the institutionalised life course, inequality in resources and opportunities, and young people’s competencies. Thanks to the longitudinal and multi-cohort design of the study, this conceptual perspective facilitates the joint examination of intra-individual development, inter-individual differences in developmental outcomes and social change in developmental processes.COCON consists of three age groups, whereby each groups represents a prototypical stage in the process of growing up: mid-childhood (6-year-olds), mid-adolescence (15-year-olds) and early adulthood (21-year-olds). The samples are representative for the French- and German-speaking parts of Switzerland. The large sample sizes and the multilingual context of Switzerland permit the analysis of group disparities as well as cross-cultural differences. The multi-informant component of the study includes the primary caregiver and class teacher.The current study profile outlines the most important characteristics of the study in the context of the conceptual framework and discusses strengths and caveats related to study management as well as ethical considerations and information on data availability.
Electric-field-assisted processing of ceramics: Nonthermal effects and related mechanisms
Authors: Guillon Olivier , De Souza Roger A. , Mishra Tarini Prasad , Rheinheimer Wolfgang 
Published: January 2021

AbstractField-assisted processing methods, such as spark plasma sintering and flash sintering, have considerably expanded the toolbox of ceramic engineering. Depending on the conditions, substantial electric currents may flow through the material resulting in fast heating rates due to Joule heating. Here, we focus on nonthermal effects induced by electric fields during processing of fluorite- and perovskite-based ceramics. The fundamentals of how a field can directly modify defect formation and migration in crystals are discussed. In addition, the interplay of ion transport and electrical conductivity is considered, this interplay being crucial to understanding nonthermal effects caused by electric fields (as in memristive switching). Electrochemical reactions leading to new phases or reduction are also described, as are densification rates and sintering parameters that are significantly affected even though the sample temperature is held constant. Finally, as grain-boundary properties and segregation are changed by ion transport, we describe how both retardation and acceleration of grain growth can be achieved including graded microstructures.
Value of 18F-fluorodeoxyglucose positron emission tomography combined with computed tomography in staging of patients with differentiated thyroid cancer after thyroidectomy during the first course of radioiodine therapy
Authors: Geliashvili T. M. , Vazhenin A. V. , Berezovskaya T. P. , Vasilieva E. B. , Afanasieva N. G. , Krylov V. V. , Garbuzov P. I. 
Published: January 2021

The study objective is to evaluate value of 18F-fluorodeoxyglucose positron emission tomography combined with computed tomography (PET-CT) and whole-body scintigraphy (131I-WBS) performed during the first course of radioiodine therapy for its ability to detect persistence metastatic foci and for its role in the management of differentiated thyroid cancer patients.Materials and methods. Forty patients with DTC underwent both post-therapeutic 131I-WBS and PET-CT. PET-CT performed on a positron emission tomograph combined with a 16-slice computer tomograph. Post-therapeutic 131I-WBS performed during radioiodine therapy on the single-detector gamma camera.Results. Sensitivity in detecting of the tumor persistence for PET-CT was 84 %, for post-therapeutic 131I-WBS 66 % (р >0.05). In 17 (42.5 %) patients additional PET-CT foci were found that negative on 131I-WBS, including 11 (27.5 %) cases of distant metastases. Fifteen percent of patients had metastatic foci visualized only on 131I-WBS, including 4 (10 %) cases of distant metastases. In 17 (44 %) patients tumor foci were identified by both methods. A high pre-ablative level of stimulated thyroglobulin was the only independent predictor of the presence of PET-CTpositive metastatic foci (p = 0.001).Conclusion. 18F-fluorodeoxyglucose PET-CT can be recommended during the first radioiodine therapy in differentiated thyroid cancer patients with a high risk progression group, as well as with suspected the tumor persistence in case of a high pre-ablation thyroglobulin level, to complete staging, improve the quality of management and ongoing risk stratification.
Results of implementation of a program of individual support of chemoradiation therapy in patients with head and neck tumors
Authors: Gevorkov A. R. , Boyko A. V. , Bolotina L. V. , Shashkov S. V. , Abuzarova G. R. , Sarmanaeva R. R. 
Published: January 2021

The study objective is to improve quality of life in patients with oropharyngeal squamous-cell carcinoma during chemo/bioradiation therapy and at early stages after its completion which allows to perform the full extent of radiation within optimal treatment period.Materials and methods. A retrospective analysis of data on 196 patients who underwent chemoradiation therapy between 2005 and 2016 was performed. The results were used to develop and implement a program of support for chemo/bioradiotherapy. The program was characterized by: 1. use of Russian hydrogel materials for local delivery of antibiotics and wound-healing, anesthetizing, anti-inflammatory medications; 2. new regimens of pain relief with differentiated pathogenetic approach and use of modern transdermal long-acting forms; 3. nutritional support at every treatment stage; 4. assurance of compliancy. To evaluate the program, prospective randomized controlled study was performed between January of 2017 and March of 2019 including 60 patients.Results. Mucositis and dermatitis severity and changes in physical state associated with them, progression and duration of radiation did not significantly differ in the two groups. Use of the support program allowed to control adverse effects and to perform chemoradiotherapy to the full extent, at optimal time and with satisfactory quality of life.Conclusion. The program of support of chemo/bioradiotherapy in combination with psychological support is effective both form the point of view of optimization of treatment and rehabilitation times and from the point of view of maintenance of high quality of life in patients.
Comparison between efficacy of Epley’s maneuver with medical therapy versus medical therapy alone in treating BPPV patients
Authors: Kavathia Krima , Bathla Meeta , Doshi Hiren , Patel Hemangi , Bhagat Priyanka 
Published: January 2021

Dizziness and disequilibrium are common complaints in both general adult and the geriatric population. Dizziness is often used to describe the sensations of vertigo, lightheadedness, imbalance, presyncope, disorientation, and/or gait instability. The cause may be otologic, neurologic, cardiovascular, psychiatric, orthopedic or ophthalmologic. Benign paroxysmal positional vertigo(BPPV) is, by far, the most common cause of episodic vertigo. This study was done in a tertiary care center of Ahmedabad, Gujarat, in patients above age of 20 and with BPPV. The purpose of the study was to compare the efficacy of Epley’s maneuver with medical therapy versus medical therapy alone in patients of BPPV.A total of 50 patients were divided into two groups: 25 to the group A which received Epley’s maneuver with drug therapy and 25 to the group B which received only drug therapy. In our study, Epley’s maneuver with medical therapy was found to be more effective than medicine given alone.This study shows that the Epley maneuver with medical therapy provides effective and long-term control of symptoms in patients with BPPV. It benefits over medical therapy alone in terms of avoiding the delay in vestibular compensation and recurrence.