bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental health in relation to changes in sleep, exercise, alcohol and diet during the COVID-19 pandemic: examination of four UK cohort studies
Authors: Villadsen Aase , Patalay Praveetha , Bann David 
Published: November 2021

AbstractBackgroundResponses to the COVID-19 pandemic have included lockdowns and social distancing with considerable disruptions to people's lives. These changes may have particularly impacted on those with mental health problems, leading to a worsening of inequalities in the behaviours which influence health.MethodsWe used data from four national longitudinal British cohort studies (N= 10 666). Respondents reported mental health (psychological distress and anxiety/depression symptoms) and health behaviours (alcohol, diet, physical activity and sleep) before and during the pandemic. Associations between pre-pandemic mental ill-health and pandemic mental ill-health and health behaviours were examined using logistic regression; pooled effects were estimated using meta-analysis.ResultsWorse mental health was related to adverse health behaviours; effect sizes were largest for sleep, exercise and diet, and weaker for alcohol. The associations between poor mental health and adverse health behaviours were larger during the May lockdown than pre-pandemic. In September, when restrictions had eased, inequalities had largely reverted to pre-pandemic levels. A notable exception was for sleep, where differences by mental health status remained high. Risk differences for adverse sleep for those with the highest level of prior mental ill-health compared to those with the lowest were 21.2% (95% CI 16.2–26.2) before lockdown, 25.5% (20.0–30.3) in May and 28.2% (21.2–35.2) in September.ConclusionsTaken together, our findings suggest that mental health is an increasingly important factor in health behaviour inequality in the COVID era. The promotion of mental health may thus be an important component of improving post-COVID population health.
Comparison of ARIMA, ES, GRNN and ARIMA–GRNN hybrid models to forecast the second wave of COVID-19 in India and the United States
Authors: Wang Gang , Wu Tiantian , Wei Wudi , Jiang Junjun , An Sanqi , Liang Bingyu , Ye Li , Liang Hao 
Published: November 2021

Abstract
As acute infectious pneumonia, the coronavirus disease-2019 (COVID-19) has created unique challenges for each nation and region. Both India and the United States (US) have experienced a second outbreak, resulting in a severe disease burden. The study aimed to develop optimal models to predict the daily new cases, in order to help to develop public health strategies. The autoregressive integrated moving average (ARIMA) models, generalised regression neural network (GRNN) models, ARIMA–GRNN hybrid model and exponential smoothing (ES) model were used to fit the daily new cases. The performances were evaluated by minimum mean absolute per cent error (MAPE). The predictive value with ARIMA (3, 1, 3) (1, 1, 1)14 model was closest to the actual value in India, while the ARIMA–GRNN presented a better performance in the US. According to the models, the number of daily new COVID-19 cases in India continued to decrease after 27 May 2021. In conclusion, the ARIMA model presented to be the best-fit model in forecasting daily COVID-19 new cases in India, and the ARIMA–GRNN hybrid model had the best prediction performance in the US. The appropriate model should be selected for different regions in predicting daily new cases. The results can shed light on understanding the trends of the outbreak and giving ideas of the epidemiological stage of these regions.
Changes in dietary patterns from preconception to during pregnancy and its association with socio-demographic and lifestyle factors
Authors: Gete Dereje G , Waller Michael , Mishra Gita D 
Published: November 2021

AbstractObjective:To examine dietary patterns changes from preconception to during pregnancy and their associations with socio-demographic and lifestyle factors.Design:This study used data from the Australian Longitudinal Study on Women’s Health (ALSWH), a population-based prospective cohort study. Women’s dietary patterns were assessed using Healthy Eating Index-2015 (HEI-2015) score and the four patterns were obtained from the factor analysis (Western diets, vegetable and grains, traditional vegetable and fruit patterns). Multi-variable linear regression and repeated measures mixed-effect models were used.Setting:A national representative survey which covers all Australian citizens and permanent residents in Australia.Participants:621 women were included from the ALSWH.Results:Women’s scores increased on the ‘HEI-2015’, ‘traditional vegetable’ and ‘fruit’ patterns while the ‘vegetable and grains’ decreased from preconception to during pregnancy. Women with higher education were more likely to increase their HEI-2015 score and fruit consumption from preconception to during pregnancy, respectively (β = 2·31, (95 % CI 0·02, 4·60)) and (β = 23·78, (95 % CI 4·58, 42·97)), than those with lower educational status. Single women were more likely to increase the consumption of vegetables and grains compared to married women (β = 76·08, (95 % CI 20·83, 131·32)). Women with higher income had a greater increase in the HEI-2015 score than those with lower income (β = 3·02, (95 % CI 0·21, 5·83)).Conclusion:The findings indicate that there have been marked dietary changes from preconception to during pregnancy. Changes in healthy dietary patterns were influenced by education, marital status and income.
Exploring CBT therapists’ experience of feeling of safety within self-practice/self-reflection: an interpretative phenomenological analysis
Authors: Mackenzie Murray , O’Mahony James 
Published: November 2021

Abstract
Self-practice/self-reflection (SP/SR) is an experiential training strategy implemented to develop the skills of CBT therapists through the self-application of CBT techniques and subsequent reflection on the experience in relation to clinical practice. Outcome studies report significant personal and professional benefits from SP/SR but engagement studies suggest that CBT therapists’ experience is mixed. In order to inform the design and implementation of SP/SR within CBT, this study aims to explore CBT therapists’ experience of feeling of safety (FOS) within SP/SR. FOS has been identified as an important engagement factor. Three CBT therapists were interviewed using semi-structured interviews. The data, which took the form of verbatim transcripts, were subjected to interpretative phenomenological analysis. Four superordinate themes relating to participants’ experience of FOS within SP/SR emerged: FOS and its absence as embodied and non-verbal, role of the instructor, awareness of others and venturing beyond safety. Ensuing recommendations for instructors include proactive use of interventions within SP/SR which directly impact embodied FOS, monitoring the wellbeing and engagement of participants through awareness of physical cues and employment of measures designed to promote a sense of equality among group members. Areas of future research include exploration of factors which influence FOS, investigation of the effect on FOS of pre-existing relationships within the SP/SR group and review of interventions which are currently used by SP/SR instructors to promote FOS.

Key learning aims

(1)
To explore the lived experience of FOS within SP/SR as experienced by CBT therapists.

(2)
To identify factors which influence CBT therapists’ experience of FOS within SP/SR.

(3)
To identify practical recommendations for use in SP/SR instruction which will promote participants’ FOS.
Trawling the Ocean of Grass: Soil Nitrogen in Saskatchewan Agriculture, 1916–2001
Authors: Larsen Laura 
Published: November 2021

AbstractUsing a socioecological metabolism approach to analyze data from the Census of Agriculture, this article examines the underlying soil fertility of two case study areas in the Canadian province of Saskatchewan through the calculation of soil nitrogen balances. The Rural Municipalities of Wise Creek and Livingston are 300 miles apart and therefore have different topography, soil types, and rainfall levels, even though both are within the northern Great Plains. Over 85 years, from first settlement in the 1910s until the beginning of the twenty-first century, Wise Creek agriculture focused increasingly on livestock production while in Livingston farmers began to grow a greater variety of crops, most notably incorporating canola into rotations. Despite the differences between the two case studies, the pattern of soil nitrogen losses was remarkably similar, with biomass yields declining along with soil nitrogen. The addition of chemical nitrogen fertilizers since the 1960s did not produce yields matching historic highs, nor did a renewed focus on livestock. Wise Creek and Livingston showed two different responses to declining yields, but neither one ultimately provided a long-term solution to the problem of soil nutrient depletion and consequent productivity declines.
Mining Can Exacerbate Global Degradation of Dryland
Authors: Shen Zexi , Zhang Qiang , Piao Shilong , Peñuelas Josep , Stenseth Nils Chr. , Chen Deliang , Xu Chong‐Yu , Singh Vijay P. , Liu Tingxi 
Published: November 2021

AbstractGroundwater storage (GS) is the major water resource for vegetation in drylands. Thus, positive relationships between vegetative growth condition (VGC) and GS are expected in drylands. Since mining‐induced dewatering tends to deplete GS surrounding mine sites, VGC should become less favorable due to a shortage of accessible water. However, quantitative analysis repealed the opposite. We found that global annual mineral production in drylands increased by 24%, while GS decreased by 22% but the VGC improved by 37% (2002–2010). And negative relationships between VGC and GS were detected in 84.7% of global dryland mine sites. We concluded that irrigation supported by mining‐induced dewatering promoted the vegetation growth surrounding mine sites. However, since the GS is limited, irrigation‐supported vegetation growth is unsustainable. This study elucidates the reason behind these abnormal negative relationships and highlights the potential risk of vegetation degradation induced by unsustainable groundwater depletion in global dryland mine sites.
Characterizing Hydration of the Ocean Crust Using Shortwave Infrared Microimaging Spectroscopy of ICDP Oman Drilling Project Cores
Authors: Crotteau Molly A. , Greenberger Rebecca N. , Ehlmann Bethany L. , Rossman George R. , Harris Michelle , Kelemen Peter B. , Teagle Damon A. H. ,   the Oman Drilling Project Phase 1 Science Party
Published: November 2021

AbstractAlthough ocean crust covers over 60% of Earth's surface, the processes that form, cool, and alter the ocean crust are not completely understood. We utilize shortwave infrared micro‐imaging spectroscopy of ∼1.2 km of rock cored by the International Continental Scientific Drilling Program's Oman Drilling Project to quantify hydration of basaltic dikes and gabbros from the Samail ophiolite as a function of depth, mineralogy and deformation. We develop a regression (R2 = 0.66) between area of the ∼1,350–1,650 nm OH/H2O absorption and measurements of loss on ignition of samples and apply this relationship to generate quantitative ∼250 μm/pixel hydration maps for all cores. The lowest mean hydration is observed in the most pervasively altered dike‐gabbro boundary (GT3A, H2Omean = 2.1 ± 1.6 wt%), consistent with the low H2O content of the dominant alteration minerals, amphibole and epidote. The highest H2O content occurs in deeper foliated and layered gabbros (GT2A, H2Omean = 3.2 ± 3.0 wt%) and layered gabbros (GT1A, H2Omean = 2.8 ± 3.1 wt%). The greater prevalence with depth of zeolite alteration as opposed to lower wt% H2O amphibole at shallow stratigraphic depths, as well as the occurrence of zones of intensive hydration associated with fault zones (H2Omean = 5.7 ± 4.0 wt%) lead to greater hydration of the lower ocean crust. This new approach provides an objective quantification of hydration in these cores, enabling an improved understanding of quantities and characteristics of ocean crust hydration. It highlights the importance of specific phases and faulting in controlling hydration, which has implications for ocean crust cooling, rheological properties, and the role of alteration in global biogeochemical cycling.
Stimulated or Inhibited Response of Methane Flux to Nitrogen Addition Depends on Nitrogen Levels
Authors: Chang Ruiying , Liu Xinyu , Wang Tao , Li Na , Bing Haijian 
Published: November 2021

AbstractUpland forest soil is significant atmospheric methane (CH4) sink that is suggested to be affected by increased nitrogen (N) availability, likely from N deposition or addition. However, the effect of N addition on upland soil CH4 uptake and the underlying mechanisms remain unclear. Here, in a montane forest, frequent in situ sampling over three years revealed that this forest soil was a sink of atmospheric CH4 with an uptake rate of 304.9 ± 26.9 mg CH4/m2/yr under ambient treatment. High N addition suppressed CH4 uptake by 23.2% compared to ambient conditions, whereas low N addition stimulated CH4 uptake by 35.6%. N addition did not change the monthly pattern of CH4 flux, which was quite similar to the pattern of leachate dissolved organic carbon (DOC) concentrations from the organic layer. The linear relationship between the CH4 flux and DOC concentration indicated increased CH4 uptake with an increase in DOC. The induced decrease in CH4 uptake under high N addition was partly related to the high soil N availability and partly contributed to a decrease in DOC due to high N addition. In contrast, the increased CH4 uptake under temporarily low N addition was most likely correlated with a release in N limitation to CH4‐oxidizing bacteria. These results indicated that the effect of N addition on CH4 uptake was dependent on the level of N, and DOC could regulate CH4 uptake in upland soil, which should be investigated in depth when understanding the responses of dynamic CH4 fluxes to N additions.
Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry
Authors: Sanchez-Roige Sandra , Fontanillas Pierre , Jennings Mariela V. , Bianchi Sevim B. , Huang Yuye , Hatoum Alexander S. , Sealock Julia , Davis Lea K. , Elson Sarah L. ,   23andMe Research Team, Agee Michelle , Alipanahi Babak , Auton Adam , Bell Robert K. , Bryc Katarzyna , Furlotte Nicholas A. , Hinds David A. , Huber Karen E. , Kleinman Aaron , Litterman Nadia K. , McCreight Jennifer C. , McIntyre Matthew H. , Mountain Joanna L. , Noblin Elizabeth S. , Northover Carrie A. M. , Pitts Steven J. , Sathirapongsasuti J. Fah , Sazonova Olga V. , Shelton Janie F. , Shringarpure Suyash , Tian Chao , Tung Joyce Y. , Vacic Vladimir , Wilson Catherine H. , Palmer Abraham A. 
Published: November 2021

AbstractThe growing prevalence of opioid use disorder (OUD) constitutes an urgent health crisis. Ample evidence indicates that risk for OUD is heritable. As a surrogate (or proxy) for OUD, we explored the genetic basis of using prescription opioids ‘not as prescribed’. We hypothesized that misuse of opiates might be a heritable risk factor for OUD. To test this hypothesis, we performed a genome-wide association study (GWAS) of problematic opioid use (POU) in 23andMe research participants of European ancestry (N = 132,113; 21% cases). We identified two genome-wide significant loci (rs3791033, an intronic variant of KDM4A; rs640561, an intergenic variant near LRRIQ3). POU showed positive genetic correlations with the two largest available GWAS of OUD and opioid dependence (rg = 0.64, 0.80, respectively). We also identified numerous additional genetic correlations with POU, including alcohol dependence (rg = 0.74), smoking initiation (rg = 0.63), pain relief medication intake (rg = 0.49), major depressive disorder (rg = 0.44), chronic pain (rg = 0.42), insomnia (rg = 0.39), and loneliness (rg = 0.28). Although POU was positively genetically correlated with risk-taking (rg = 0.38), conditioning POU on risk-taking did not substantially alter the magnitude or direction of these genetic correlations, suggesting that POU does not simply reflect a genetic tendency towards risky behavior. Lastly, we performed phenome- and lab-wide association analyses, which uncovered additional phenotypes that were associated with POU, including respiratory failure, insomnia, ischemic heart disease, and metabolic and blood-related biomarkers. We conclude that opioid misuse can be measured in population-based cohorts and provides a cost-effective complementary strategy for understanding the genetic basis of OUD.
Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses
Authors: Boehi Flurina , Manetsch Patrick , Hottiger Michael O. 
Published: November 2021

AbstractSignaling cascades provide integrative and interactive frameworks that allow the cell to respond to signals from its environment and/or from within the cell itself. The dynamic regulation of mammalian cell signaling pathways is often modulated by cascades of protein post-translational modifications (PTMs). ADP-ribosylation is a PTM that is catalyzed by ADP-ribosyltransferases and manifests as mono- (MARylation) or poly- (PARylation) ADP-ribosylation depending on the addition of one or multiple ADP-ribose units to protein substrates. ADP-ribosylation has recently emerged as an important cell regulator that impacts a plethora of cellular processes, including many intracellular signaling events. Here, we provide an overview of the interplay between the intracellular diphtheria toxin-like ADP-ribosyltransferase (ARTD) family members and five selected signaling pathways (including NF-κB, JAK/STAT, Wnt-β-catenin, MAPK, PI3K/AKT), which are frequently described to control or to be controlled by ADP-ribosyltransferases and how these interactions impact the cellular responses.
Molecular characterization of metabolic subtypes of gastric cancer based on metabolism-related lncRNA
Authors: Li Lingdi , Ma Jianfei 
Published: November 2021

AbstractIncreasing evidence has demonstrated that lncRNAs are critical regulators in diverse biological processes, but the function of lncRNA in metabolic regulation remains largely unexplored. In this study, we evaluated the association between lncRNA and metabolic pathways and identified metabolism-related lncRNAs. Gastric cancer can be mainly subdivided into 2 clusters based on these metabolism-related lncRNA regulators. Comparative analysis shows that these subtypes are found to be highly consistent with previously identified subtypes based on other omics data. Functional enrichment analysis shows that they are enriched in distinct biological processes. Mutation analysis shows that ABCA13 is a protective factor in subtype C1 but a risk factor in C2. Analysis of chemotherapeutic and immunotherapeutic sensitivity shows that these subtypes tend to display distinct sensitivity to the same chemical drugs. In conclusion, these findings demonstrated the significance of lncRNA in metabolic regulation. These metabolism-related lncRNA regulators can improve our understanding of the underlying mechanism of lncRNAs and advance the research of immunotherapies in the clinical management of gastric cancer.
Hospitalizations and emergency department visits trends among elderly individuals in proximity to death: a retrospective population-based study
Authors: Barbiellini Amidei Claudio , Macciò Silvia , Cantarutti Anna , Gessoni Francesca , Bardin Andrea , Zanier Loris , Canova Cristina , Simonato Lorenzo 
Published: November 2021

AbstractAcute healthcare services are extremely important, particularly during the COVID-19 pandemic, as healthcare demand has rapidly intensified, and resources have become insufficient. Studies on specific prepandemic hospitalization and emergency department visit (EDV) trends in proximity to death are limited. We examined time-trend specificities based on sex, age, and cause of death in the last 2 years of life. Datasets containing all hospitalizations and EDVs of elderly residents in Friuli-Venezia Giulia, Italy (N = 411,812), who died between 2002 and 2014 at ≥ 65 years, have been collected. We performed subgroup change-point analysis of monthly trends in the 2 years preceding death according to sex, age at death (65–74, 75–84, 85–94, and ≥ 95 years), and main cause of death (cancer, cardiovascular, or respiratory disease). The proportion of decedents (N = 142,834) accessing acute healthcare services increased exponentially in proximity to death (hospitalizations = 4.7, EDVs = 3.9 months before death). This was inversely related to age, with changes among the youngest and eldest decedents at 6.6 and 3.5 months for hospitalizations and at 4.6 and 3.3 months for EDVs, respectively. Healthcare use among cancer patients intensified earlier in life (hospitalizations = 6.8, EDVs = 5.8 months before death). Decedents from respiratory diseases were most likely to access hospital-based services during the last month of life. No sex-based differences were found. The greater use of acute healthcare services among younger decedents and cancer patients suggests that policies potentiating primary care support targeting these at-risk groups may reduce pressure on hospital-based services.
Flexible emotion regulatory selection when coping with COVID-19-related threats during quarantine
Authors: Shabat Maya , Shafir Roni , Sheppes Gal 
Published: November 2021

AbstractThe COVID-19 pandemic poses significant emotional challenges that individuals need to select how to regulate. The present study directly examined how during the pandemic, healthy individuals select between regulatory strategies to cope with varying COVID-19-related threats, and whether an adaptive flexible regulatory selection pattern will emerge in this unique threatening global context. Accordingly, this two-study investigation tested how healthy individuals during a strict state issued quarantine, behaviorally select to regulate COVID-19-related threats varying in their intensity. Study 1 created and validated an ecologically relevant set of low and high intensity sentences covering major COVID-19 facets that include experiencing physical symptoms, infection threats, and social and economic consequences. Study 2 examined the influence of the intensity of these COVID-19-related threats, on behavioral regulatory selection choices between disengagement via attentional distraction and engagement via reappraisal. Confirming a flexible regulatory selection conception, healthy individuals showed strong choice preference for engagement reappraisal when regulating low intensity COVID-19-related threats, but showed strong choice preference for disengagement distraction when regulating high intensity COVID-19-related threats. These findings support the importance of regulatory selection flexibility for psychological resilience during a major global crisis.