bluuebunny/crossref_metadata_2025_split huggingface dataset:
Six-Year Neurodevelopmental Outcomes for Children With Single-Ventricle Physiology
Authors: Sananes Renee , Goldberg Caren S. , Newburger Jane W. , Hu Chenwei , Trachtenberg Felicia , Gaynor J. William , Mahle William T. , Miller Thomas , Uzark Karen , Mussatto Kathleen A. , Pizarro Christian , Jacobs Jeffrey P. , Cnota James , Atz Andrew M. , Lai Wyman W. , Burns Kristin M. , Milazzo Angelo , Votava-Smith Jodie , Brosig Cheryl L. ,   on behalf of the PHN investigators
Published: January 2021

OBJECTIVES:
To determine if neurodevelopmental deficits in children with single-ventricle physiology change with age and early developmental scores predict 6-year outcomes.

METHODS:
In the Single Ventricle Reconstruction Trial, Bayley Scales of Infant Development, Second Edition, were administered at 14 months of age, and parents completed the Behavior Assessment System for Children, Second Edition (BASC-2) annually from the ages of 2 to 6 years. Scores were classified as average, at risk, or impaired. We calculated sensitivities, specificities, and positive and negative predictive values of earlier tests on 6-year outcomes.

RESULTS:
Of 291 eligible participants, 244 (84%) completed the BASC-2 at 6 years; more Single Ventricle Reconstruction participants than expected on the basis of normative data scored at risk or impaired on the BASC-2 Adaptive Skills Index at that evaluation (28.7% vs 15.9%; P &lt; .001). Children with Adaptive Skills Composite scores &lt;2 SD below the mean at the age of 6 were more likely to have had delayed development at 14 months, particularly on the Psychomotor Development Index (sensitivity of 79%). However, the positive predictive value of the 14-month Mental Development Index and Psychomotor Development Index for 6-year BASC-2 Adaptive Scores was low (44% and 36%, respectively). Adaptive Skills Composite score impairments at the age of 6 were poorly predicted by using earlier BASC-2 assessments, with low sensitivities at the ages of 3 (37%), 4 (48%), and 5 years (55%).

CONCLUSIONS:
Many children with hypoplastic left heart syndrome who have low adaptive skills at the age of 6 years will not be identified by screening at earlier ages. With our findings, we highlight the importance of serial evaluations for children with critical congenital heart disease throughout development.
Change of concentration of biochemical markers of dysfunction of endothelium at intake of inhibitors of tyrosinekinase of I and II generations at patients with a chronic myeloid leukemia as risk factor of development of cardiovascular complications
Authors: Naumova K. V. , Davydkin I. L. , Lomaia E. G. , Stepanova T. Yu. , Kuzmina T. P. , Zammoyeva D. B. 
Published: January 2021

CML), the accepting inhibitors tyrosine of kinases (TKI) I and the II generations (TKI1 and TKI2 respectively), and development of arterial hypertension.Material and methods. Examination of 137 patients with CML in the chronic phase (CP) is conducted, the median of age — 47 years. 24 of them were with for the first time the verified diagnosis of CML and earlier did not accept TKI, they have made group of control. Other patients accepted TKI: 39 patients — imatinib 400 mg/day, 36 — dasatinib 100 mg/day, 38 — nilotinib 800 mg/day) more than 6 months. In biochemical analysis of blood indicators of lipidic range were defined. Level detection of ET-1 and VEGF was made by means of enzyme immunoassay. To all patients measurement of the heart rate (HR) and the arterial blood pressure (ABP) on both hands at an interval of 2 minutes from previous was once taken.Results. In group of patients from CML accepting nilotinib authentically significant increase in levels of systolic and diastolic ABP (р<0,001) in comparison with group of control, with group of the patients accepting imatinib and dasatinib is noted. The most serious changes of lipidic range are noted at the patients accepting nilotinib. In all groups statistically significant increase in level of C-reactive protein, fibrinogen, homocysteine, endothelin-1 and VEGF in comparison with group of control is revealed. The most expressed changes are found in group of the patients accepting nilotinib, values of parameters of C-reactive protein, fibrinogen, homocysteine, endothelin-1 and VEGF are changed authentically (р<0,001) and statistically significantly differ in comparison with group for the first time of the revealed patients with CML and groups of reception of imatinib and dazatinib.Conclusion. As a result of the conducted research endothelium variation of a function at patients from CML accepting TKI1 and TKI2 is revealed. The above-stated indicators can be used as additional diagnostic criteria for assessment of risk of development of arterial hypertension in patients with CML at reception of TKI.
The Amelioration of our Spelling
Authors: Thomas Calvin 
Published: January 2021

Let me first of all account for the title of this paper by quoting a few words from a recent editorial of the New York Evening Post:“If time-worn phrases prevent a calm scrutiny of the facts, and a clear perception of the best fiscal policy for this nation .... let us abandon them for some fresher and truer form of words. . . . Instead of taking free trade for a watchword, if that offends any, we may say that we stand for freer trade. Instead of talking about protecting American industry, let us talk about facilitating it.”
XXIV.—Sir Perceval and The Boyish Exploits of Finn
Authors: Pace Roy Bennett 
Published: January 2021

The relations between the English romance, Sir Perceval, and its counterparts in French, German, and Welsh have been frequently and extensively investigated. Efforts have been made also to show connections between the story of Perceval (especially the boyhood portion) and various other stories—the “Fair Unknown” (Libeaus Desconus) group, the romance of Fergus, the lai of Tyolet, and the Irish tales of Cuchullin.Another Irish story which has not, it seems to me, received the attention it merits in this connection is The Boyish Exploits of Finn. The resemblances between it and the English romance were first pointed out by Alfred Nutt in 1881. He believed The Boyish Exploits to he a fifteenth-century composition; and he repeated this belief in 1888, 1891, and 1910. This late date was supported in long arguments by Zimmer in 1890 and 1891; and it has been generally accepted by students of the story, including d'Arbois de Jubainville, Newell, Miss Paton, Miss Weston, and Professors Schofield and Griffith.
MLA Foreign Language Proficiency Tests for Teachers and Advanced Students
Authors: Starr Wilmarth H. 
Published: January 2021

I. Brief History of the Project: Since 1952, the Foreign Language Program of the Modern Language Association of America, responding to the national urgency with regard to foreign languages, has been engaged in a vigorous campaign aimed in large part at improving foreign-language teaching in our country.In 1955, as one of its activities, the Steering Committee of the Foreign Language Program formulated the “Qualifications for Secondary School Teachers of Modern Foreign Languages,” a statement which was subsequently endorsed for publication by the MLA Executive Council, by the Modern Language Committee of the Secondary Education Board, by the Committee on the Language Program of the American Council of Learned Societies, and by the executive boards or councils of the following national and regional organizations: National Federation of Modern Language Teachers Associations, American Association of Teachers of French, American Association of Teachers of German, American Association of Teachers of Italian, American Association of Teachers of Spanish and Portuguese, American Association of Teachers of Slavic and East European Languages, Central States Modern Language Teachers Association, Middle States Association of Modern Language Teachers, New England Modern Language Association, Northeast Conference on the Teaching of Foreign Languages, Northwest Conference on Foreign Language Teaching, Philological Association of the Pacific Coast, Rocky Mountain Modern Language Association, South Atlantic Modern Language Association, and South-Central Modern Language Association.
MANAGEMENT EDUCATION REFORM AS A PREREQUISITE FOR STABLE DEVELOPMENT OF THE ECONOMY
Authors: Gitelman L. D. , Isayev A. P. , Kozhevnikov M. V. 
Published: January 2021

The article is devoted to priority solutions for launching systemic transformations of managerial education for the technological breakthrough. The basis for the development of such decisions was the scientific direction “Proactive Management in Actively Developing Industries and Economic Sectors”, in which the authors work, and the experience in creating educational products that meet the latest trends, including those that have appeared recently.The research methodology included analysis of scientific literature on the problems of complex systems development, proactive management and anticipatory training, systematization of educational practices for managers in foreign and domestic universities, conducting surveys of experts – heads of Russian large industrial enterprises, professors and students.The key reasons for the unsatisfactory state of management education are identified and a set of recommendations for its reform has been developed. Changes in organizational models of managerial education are proposed, the principles of implementing fundamental training and enhancing the humanization of education with a simultaneous increase in the level of knowledge of the scientific and technical foundations of production process are formulated. The conditions of increasing the effectiveness of students’ practical training are considered, the forms of its implementation are determined to ensure the readiness of graduates to work in managerial positions. The results of long-term studies of anticipatory training, from managers at the lower levels to directors of large companies, are carried out. These results were obtained in the scientific and educational center “INZHEK” of the Ural Federal University and tested at various levels of management education (bachelor’s, master’s degrees).The results of the study are of practical interest to managers and professors of universities, business schools and corporate universities, as well as to top managers of business structures involved in improving personnel training.
Review of urological cancers in Damaturu, Nigeria
Authors: Tela Usman M. , Adamu Adamu I. , Abubakar Babagana M. , Abubakar Abdulkadir , Dogo Hassan M. 
Published: January 2021

Background: Urological cancers (UC) remain a major global burden and a significant cause of high morbidity and mortality. In other to plan and tackle this burden, there is need to audit the pattern of these malignancies in our locality which is currently lacking. Hence, the objectives of our study were to describe the histological pattern, frequency and demographic characteristics of urological cancers seen in Damaturu.Methods: The reports of all the urological specimens that were histologically diagnosed as malignant between November 2017 to October 2019 in the histopathology department of Yobe state university teaching hospital, were analyzed. The department keeps newly established cancer registry for the state.Results: Fifty-five UC were diagnosed, with male to female ratio of 13.8:1. These UC constitute 34.1% of the 161 urological specimens assessed and 26.4% of all types of medical cancers diagnosed in the period of study. Prostate cancer dominates the UC (41; 73.8%), followed by bladder cancers (11; 19.8%) and the remaining kidney, penis and testicular cancers (1; 1.8%) each.Conclusions: Urological cancers are very common in our region, particularly prostate cancers in which majority were poorly differentiated. This report though analyzed few cancers, the proportion of UC is high. Urothelial cancer of the bladder is now more frequent than squamous cell carcinoma. This study can serve as basis for future epidemiologic studies targeting at the risk factors, awareness and prevention of UC.
Epidemiological determinants of parasitic infestation among 6-12 years old children in peri-urban area of Rohtak, Haryana, India
Authors: Devi Murti , Chayal Vinod 
Published: January 2021

Background: Intestinal parasitic infestation is one of the commonest causes of chronic infection in humans in developing countries and is responsible for considerable morbidity and mortality. Despite the improved socio-economic conditions and elevated living standards, surprisingly it is still a public health problem even in developed countries, like the United States. Objectives of the study were to determine the association of factors associated with parasitic infestation among children of 6-12 years age.Methods: A cross sectional survey approach was adopted to collect the data and 200 children (6-12 years) and their parents were finally included as per research criteria. Data was collected by interviewing the parents and children using structured interview schedule. Microscopic examinations of stool samples were also done for detection of ova and cysts of intestinal parasites.Results: Out of 200 study subjects 65 (32.5%) were found to be positive for parasitic infestation namely Giardia lamblia (18.0%) E. histolytica (8.5%), Taenia (4.5%) and H. nana (1.5%). Majority of parasitic infestation i.e. (58.7%) was found among the children of illiterate mothers, (44.6%) in case of joint families and (44.8%) belonging to families having a monthly income less than Rs. 5,000.Conclusions: In this study, it was found that mother’s education, family income, type of family are significantly associated factors with parasitic infestation. The present study opens an area for the further planning such as improving the low socio-economic status, regular deworming of the children, promotion of usages of toilets and up gradation of water supply system as preventive measures in this setting.
Glucose variability in pregnant women with newly diagnosed hyperglycemia
Authors: Plekhanova M. A. , Burumkulova F. F. , Petrukhin V. A. , Budykina T. S. , Panov A. E. 
Published: January 2021

Background: High-performance parallel next-generation sequencing (NGS) allows for identification of various maturity-onset diabetes of the young (MODY) subtypes also during pregnancy. As this method is expensive and time-consuming, it has proposed to use various predictors for the diagnosis of mutation in the hexokinase (GCK)/MODY2 gene, helping to select the patients for subsequent molecular genetic testing. Hyperglycemia due to MODY2 is commonly newly diagnosed during pregnancy; therefore, there is a search for factors specific to this mutation in pregnant women.Aim: To evaluate blood glucose variability in pregnant women with newly diagnosed hyperglycemia at early gestation and to determine the threshold value of the glycemic variability coefficient for pregnant women with a mutation in the GCK/MODY2 gene.Materials and methods: This observational single center study included 41 pregnant women with newly diagnosed early hyperglycemia (not meeting the criteria for manifest diabetes mellitus). Molecular genetic testing was performed in all of them. According to its results, they were retrospectively categorized into two groups: with early gestational diabetes mellitus (GDM, no mutations) and with hyperglycemia related to a mutation in the GCK/MODY2 gene. A comparative analysis of glycemic variability in the two groups was performed. Sensitivity and specificity of the cutoff value for the coefficient of variability as a diagnostic marker of MODY2 were also calculated.Results: The pregnant women with GDM had significantly higher age and body mass index (BMI) than those with MODY2 (p<0.05). There were significant differences in venous fasting plasma glucose and glycated hemoglobin, with these parameters being higher in the pregnant women with MODY2 (p<0.05). In the patients with a mutation in the GCK gene, hyperglycemia was diagnosed earlier and insulin therapy was started earlier during pregnancy than in those with GDM (p<0.05). The ROC analysis of the diagnostic accuracy of the variability coefficient showed that at the threshold CV (coefficient of variation) value of 20.8, the area under the curve was 0.742 (95% confidence intervals 0.597 to 0.888; p<0.005), with the sensitivity of 65% and the specificity of 65.4%.Conclusion: The calculated sensitivity of 65% and specificity of 65.4% for the CV of 20.8 do not allow for its use as an independent selection criterion for subsequent confirmation of MODY2. However, its combination with the A.J. Chakera criteria (BMI<25 kg/m2 and fasting glucose≥5.5 mmol with 68% sensitivity and 96% specificity) allows to clarify the category of pregnant women with newly detected early hyperglycemia, to whom the search for mutations in the GCK gene should be recommended.
Effect of Investment Decision and Tax Management on Stock Liquidity
Authors: Pandiangan Roristua , Murwaningsari Etty 
Published: January 2021

The purpose of this study investigate effect of investment decisions, tax management on stock liquidity and investigate the effect of investment decisions, tax management on stock liquidity which moderated by liquidity. Novelty in the study is on the measurement of tax management variables, the contribution of this study is to introduce a new measurement of tax management and to provide information about investor responses and prospective investors in the stock market on tax management by companies in the context of Indonesia. The population of this study is manufacturing companies listed on the Indonesia Stock Exchange, determination of study samples using purposive sampling method with the criteria listed before 2015, complete data and non-delisting so as to obtain 127 manufacturing companies with 5 years observation year (2014-2018) and obtained 635 company years data, multiple regression analysis and moderate regression analysis (MRA) were used in this study. Research findings: 1) Investment Decisions, Tax Management simultaneously influences and significant affects Stock Liquidity. 2) Investment Decisions have an effect and significant on Stock Liquidity. 3) Tax Management has an effect and is not significant on Stock Liquidity. 4) The effect of Investment Decisions on Stock Liquidity is not moderated by liquidity. 5) The effect of Tax Management on Stock Liquidity is not moderated by liquidity.
PRODUKSI BERSIH PADA HOME INDUSTRI DALAM RANGKA PENGENDALIAN PELESTARIAN LINGKUNGAN
Authors: Zakiyah Laila Farichatuz 
Published: January 2021

Abstrak
Konsep produksi bersih (Cleaner Production) dicetuskan oleh United Nation Environmental Program (UNEP) pada bulan Mei 1989. UNEP menyatakan bahwa produksi bersih merupakan suatu strategi pengelolaan lingkungan yang bersifat preventif, terpadu dan diterapkan secara kontinu pada proses produksi, produk, jasa untuk meningkatkan eko-efisiensi sehingga mengurangi resiko terhadap kesehatan manusia dan lingkungan (Winardi & Susanti,2006). Penelitian dilakukan di Marcellina Silver Jl. Raya Celuk Sukawati Gianyar Bali pada tanggal 12 Mei 2018. Teknik pengumpulan data yang digunakan dalam penelitian ini berasal dari variable-variabel penelitian yakni produksi bersih (X1) dan pelestarian lingkungan (X2). Diperoleh dengan cara memberikan angket (kuesioner) kepada sampel penelitian (pengusaha) untuk diisi jawaban sesuai dengan pernyataan yang dibuat. Industri perak Marcellina Silver telah menerapkan produksi bersih dengan cara melakukan beberapa kegiatan seperti, mematikan kran air jika tidak digunakan dan mematikan lampu saat siang hari, menggunakan kembali bahan sisa produksi untuk dijadikan barang produk jadi dan juga melakukan perawatan atau maintenance pada mesin produksi sehingga dapat melakukan produksi dengan optimal.
Kata kunci : Industri Rumahan, Pelestarian Lingkungan, Produksi Bersih
REEVALUATION OF THE INFERRED RELATIONSHIP BETWEEN LIVING RHODOLITH MORPHOLOGIES, THEIR MOVEMENT, AND WATER ENERGY: IMPLICATIONS FOR INTERPRETING PALEOCEANOGRAPHIC CONDITIONS
Authors: O'CONNELL LAURA G. , JAMES NOEL P. , HARVEY ADELA S. , LUICK JOHN , BONE YVONNE , SHEPHERD SCORESBY A. 
Published: January 2021

ABSTRACTFree-living forms of crustose coralline algae (rhodoliths) accumulate on shallow-water marine shelves in many regions worldwide. They form their own benthic habitats termed ‘rhodolith beds' and their deposits are well preserved in the rock record. Characteristics of rhodolith deposits can be used to interpret ancient water depths, light levels, and water energies. Accurate paleoceanographic interpretations rely on large-scale, detailed studies of living rhodolith beds, but these studies are scarce. Spencer Gulf in South Australia has the largest living rhodolith beds in southeastern Australia (∼ 3,000 km2). Documentation of these rhodolith deposits includes facies analysis, coralline algal taxonomy, characterization of growth forms and morphometrics, and integration with oceanographic data. Extensive oceanographic data and hydrodynamic modeling enable comparisons between rhodolith morphologies and bottom water energies with unprecedented accuracy. Rhodolith deposits in the gulf are intermixed with carbonate sands and muds under diverse hydrodynamic conditions, with current speeds up to 1.04 m s−1. At least five coralline algal genera construct rhodoliths in Spencer Gulf. Growth forms include fruticose, lumpy, and warty. Rhodolith morphologies imply that water energy is not the only thing affecting rhodolith movement and growth; rhodoliths can also be shifted by fish and invertebrates. Linear regression models in this study evaluate relationships between rhodolith morphometrics (mean diameter, sphericity, and branch density) and maximum bottom water speeds in Spencer Gulf and their results support the idea that water energy is not a major control on rhodolith morphology under these water energy conditions. Previous studies have revealed that the relationship between rhodolith morphologies and water energy levels is complicated and many authors have cautioned to not rely solely on rhodolith morphologies to interpret paleoceanographic conditions. Results of this study demonstrate that accurate paleoceanographic interpretations cannot be made based on rhodolith morphologies alone, but should also include sedimentology, coralline taxonomy, and associated biota.