bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theodotion Zechariah in the Fourth Gospel
Authors: Moore Colton 
Published: March 2021

Abstract
This article attempts demonstrate that the only two citations of Zechariah in the Fourth Gospel likely derive from “proto-Theodotion” Zechariah (Zech-θ). We first see that the Greek revision Theodotion was extant and available to the authors of the New Testament. Next, we see that the Fourth Gospel’s citation of Zech 9:9 in John 12:15 derives from Zech-θ and does not necessarily rely on Matthew’s Gospel, which itself uses Zech-θ. The most critical piece of evidence for this conclusion is found in the genitive ὄνου, which neither the Old Greek (OG) nor Matthew’s Gospel preserves, but is found explicitly in Zech-θ. We then examine Zech 12:10 in John 19:37 and conclude that it, too, ultimately derives from Zech-θ. This conclusion is plausible because (1) the Fourth Gospel typically uses the Greek versions when citing the OT, (2) Zech-θ was likely at the author’s disposal when writing the Gospel, and (3) the prepositional phrase εἰς ὃν ἐξεκέντησαν reads verbatim with Zech-θ.
The Evolving Weather Service: Forecasters’ Perceptions of Their Relationships with Core Partners
Authors: Liu Brooke Fisher , Seate Anita Atwell 
Published: March 2021

AbstractSince the tragic tornado outbreaks in central Alabama and Joplin, Missouri, in 2011, the National Weather Service (NWS) has increasingly emphasized the importance of supporting community partners who help to protect public safety. Through impact-based decision support services (IDSS), NWS forecasters develop relationships with their core partners to meet their partners’ decision-making needs. IDSS presents a fundamental shift in NWS forecasting through highlighting the importance of connecting with partners instead of simply providing partners with forecasts. A critical challenge to the effective implementation of IDSS is a lack of social science research evaluating the success of IDSS. This paper addresses this gap through a cross-sectional survey with 119 NWS forecasters and managers in the central and southern regions of the United States. Findings uncover how NWS forecasters and management team members evaluate the importance of IDSS. Findings also provide a new instrument for NWS field offices to assess and improve their relationships with core partners.
ENVIRONMENTAL DISASTERS IN NORTHEAST BRAZIL: HYDROMETEOROLOGICAL, SOCIAL AND SANITARY FACTORS
Authors: Ribeiro Marcos Samuel Matias , Andrade Lara de Melo Barbosa , Constantino Spyrides Maria Helena , Lima Kellen Carla , Evangelista da Silva Pollyane , Batista Douglas Toledo , de Lara Idemauro Antônio Rodrigues 
Published: March 2021

AbstractThe occurrence of environmental disasters affects different social segments, impacting health, education, housing, economy and the provision of basic services. Thus, the objective of this study was to estimate the relationship between the occurrence of disasters and extreme climate, sociosanitary and demographic conditions in the Northeast region of Brazil during the period from 1993 to 2013. Initially, we analyzed the spatial pattern of the incidence of events and, subsequently, generalized additive models for location, scale and shape were used in order to identify and estimate the magnitude of associations between factors. Results showed that droughts are the predominant disasters in the NEB representing 81.1% of the cases, followed by events triggered by excessive rainfall such as flash floods (11.1%) and floods (7.8%). Climate conditions presented statistically significant associations with the analyzed disasters, in which indicators of excess rainfall positively contributed to the occurrence of flash floods and floods, but negatively contributed to the occurrence of drought. Sociosanitary factors, such as percentage of households with inadequate sewage, waste collection and water supply, were also positively associated with the model’s estimations, i.e., contributing to an increase in the occurrence of events, with the exception of floods, which were not significantly influenced by sociosanitary parameters. A decrease of 19% in the risk of drought occurrence was estimated, on average. On the other hand, events caused by excessive rainfall increased by 40% and 57%, in the cases of flash floods and floods, respectively.
Factors Associated With Unilateral Hearing Loss and Impact on Communication in US Adults
Authors: Choi Janet S. , Wu Franklin , Park Soyun , Friedman Rick A. , Kari Elina , Volker Courtney C. J. 
Published: March 2021

ObjectiveTo investigate the factors associated with unilateral hearing loss (UHL) and its impact on communication in US adults.Study DesignCross‐sectional study.SettingNationally representative sample of US adults.MethodsWe analyzed data from the 2011‐2012 and 2015‐2016 National Health and Nutritional Examination Survey, in which participants aged 20 to 69 years completed an audiometric evaluation (n = 8138). UHL was defined as a speech frequency pure‐tone average ≥25 dB in the worse hearing ear and <25 dB in the better hearing ear. Logistic regression was used to examine the association between UHL and relevant factors.ResultsThe prevalence of UHL was 8.1% (95% CI, 7.3%‐9.0%) in US adults. Factors associated with UHL included older age, male sex, white race, lower level of education, diabetes, cardiovascular disease, and off‐work noise exposure. Among adults with UHL, 40% (95% CI, 32%‐48%) reported subjective trouble with hearing, a rate higher than the 12% (95% CI, 11%‐14%) among normal‐hearing adults. After adjusting for relevant factors, adults with UHL were more likely to report difficulties with following conversations with noise (odds ratio [OR], 1.7; 95% CI, 1.2‐2.5) and frustration when talking to family and friends (OR, 3.0; 95% CI, 1.9‐4.6). Higher levels of communication difficulties were observed with worsening level of UHL.ConclusionsAdults with UHL report significant communication difficulties in comparison to normal‐hearing adults. Further research is needed to understand the psychosocial impact of UHL on adults and ways to improve communication support for adults with UHL.
Segmentally impaired left ventricular longitudinal strain: a new predictive diagnostic parameter for asymptomatic patients with severe aortic stenosis and preserved ejection fraction
Authors: Kostakou Peggy M , Tryfou Elsie S , Kostopoulos Vassilios S , Markos Lambros I , Damaskos Dimitrios S , Olympios Christoforos D , Kouris Nikos T 
Published: March 2021

Introduction: This study aims to investigate the correlation between severe aortic stenosis (sAS) and impairment of left ventricular global longitudinal strain (LVGLS) in particular segments, using two-dimensional speckle tracking echocardiography in patients with sAS and normal ejection fraction of left ventricle (LVEF). Methods: The study included 53 consecutive patients with asymptomatic sAS and preserved LVEF. The regional longitudinal systolic LV wall strain was evaluated at the area opposite of the aorta as the median strain value of the basal, middle, and apical segments of the lateral and posterior walls and was compared to the average strain value of the interventricular septum (IVS) at the same views. Results: LVGLS was decreased and was not statistically different between three- and four-chamber views (−12.5 ± 3.6 vs −11.4 ± 5.5%, p = 0.2). The average strain values of the lateral and posterior walls were statistically reduced compared to the average value of the IVS (lateral vs IVS: −7.8 ± 3.7 vs −10 ± 5.3%, p = 0.005, posterior vs IVS: −7.7 ± 4.2 vs −10.3 ± 3.8%, p < 0.0001). There was no significant difference between lateral and posterior walls (−7.8 ± 3.7 vs −7.7 ± 4.2%, p = 0.9). Conclusions: The strain of lateral and posterior walls of left ventricle, which lay just opposite to the aortic valve seem to be more reduced compared to other walls in patients with sAS and preserved LVEF possibly due to their anatomical position. This impairment seems to be the reason of the overall LVGLS reduction. Regional strain could be used as an extra tool for the estimation of the severity of AS as well as for prognostic information in asymptomatic patients.
‘Necessity is the mother of invention’: Specialist palliative care service innovation and practice change in response to COVID-19. Results from a multinational survey (CovPall)
Authors: Dunleavy Lesley , Preston Nancy , Bajwah Sabrina , Bradshaw Andy , Cripps Rachel , Fraser Lorna K , Maddocks Matthew , Hocaoglu Mevhibe , Murtagh Fliss EM , Oluyase Adejoke O , Sleeman Katherine E , Higginson Irene J , Walshe Catherine 
Published: March 2021

Background: Specialist palliative care services have a key role in a whole system response to COVID-19, a disease caused by the SARS-CoV-2 virus. There is a need to understand service response to share good practice and prepare for future care. Aim: To map and understand specialist palliative care services innovations and practice changes in response to COVID-19. Design: Online survey of specialist palliative care providers (CovPall), disseminated via key stakeholders. Data collected on service characteristics, innovations and changes in response to COVID-19. Statistical analysis included frequencies, proportions and means, and free-text comments were analysed using a qualitative framework approach. Setting/participants: Inpatient palliative care units, home nursing services, hospital and home palliative care teams from any country. Results: Four hundred and fifty-eight respondents: 277 UK, 85 Europe (except UK), 95 World (except UK and Europe), 1 missing country. 54.8% provided care across 2+ settings; 47.4% hospital palliative care teams, 57% in-patient palliative care units and 57% home palliative care teams. The crisis context meant services implemented rapid changes. Changes involved streamlining, extending and increasing outreach of services, using technology to facilitate communication, and implementing staff wellbeing innovations. Barriers included; fear and anxiety, duplication of effort, information overload and funding. Enablers included; collaborative teamwork, staff flexibility, a pre-existing IT infrastructure and strong leadership. Conclusions: Specialist palliative care services have been flexible, highly adaptive and have adopted low-cost solutions, also called ‘frugal innovations’, in response to COVID-19. In addition to financial support, greater collaboration is essential to minimise duplication of effort and optimise resource use. ISRCTN16561225 https://doi.org/10.1186/ISRCTN16561225
Indiana Medical Resident’s Knowledge of Surrogate Decision Making Laws
Authors: Bartlett Stephanie , Fettig Lyle P. , Baenziger Peter H. , DiOrio Eliana N. , Herget Kayla M. , D’Cruz Lynn , Coughlin Johanna R. , Lake Mikaela , Truong Amy , Comer Amber R. 
Published: March 2021

Introduction During the care of incapacitated patients, physicians, and medical residents discuss treatment options and gain consent to treat through healthcare surrogates. The purpose of this study is to ascertain medical residents’ knowledge of healthcare consent laws, application during clinical practice, and appraise the education residents received regarding surrogate decision making laws. Methods Beginning in February of 2018, 35 of 113 medical residents working with patients within Indiana completed a survey. The survey explored medical residents’ knowledge of health care surrogate consent laws utilized in Indiana hospitals and Veterans Affairs (VA) hospitals via clinical vignettes. Results Only 22.9% of medical residents knew the default state law in Indiana did not have a hierarchy for settling disputes among surrogates. Medical residents correctly identified which family members could participate in medical decisions 86% of the time. Under the Veterans Affairs surrogate law, medical residents correctly identified appropriate family members or friends 50% of the time and incorrectly acknowledged the chief decision makers during a dispute 30% of the time. All medical residents report only having little or some knowledge of surrogate decision making laws with only 43% having remembered receiving surrogate decision making training during their residency. Conclusions These findings demonstrate that medical residents lack understanding of surrogate decision making laws. In order to ensure medical decisions are made by the appropriate surrogates and patient autonomy is upheld, an educational intervention is required to train medical residents about surrogate decision making laws and how they are used in clinical practice.
Physical Functioning Among Community-Dwelling Elderly in Rural Indonesia
Authors: Aji Budi , Wijayanti Siwi Pramatama Mars , Masfiah Siti , Anandari Dian , Chamchan Chalermpol 
Published: March 2021

Background As people live longer and the number of elderly individuals increases, caring for the elderly and increasing quality of life become important health care concerns. Objective The aim of this study is to assess physical functioning among elderly people in rural Indonesia and draw conclusions about factors that might impact physical functioning. Methods This study involved 412 elderly individuals aged 60 and over selected by multistage random sampling. A logistic regression was used to determine factors which associated with physical functioning. Results Older age (75+), suffered from chronic illness, and living in low- and middle- income households tend to have limitations on physical function. Also, elderly individuals who had partner and were currently working experienced better physical function than those who did not. Conclusion This study supports other findings that say elderly people should do activities that reduce the risk of developing chronic illnesses. Having regular physical activity and routine preventive health check-ups can improve overall health, protect from having diseases and maintain the physical function of the elderly.
New score for prediction of morbidity in patients undergoing open pancreaticoduodenectomy
Authors: Chen Lian , Peng Li , Wang Chao , Li Sheng-Chao , Zhang Meng 
Published: March 2021

Objective The Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity (POSSUM) is commonly used to predict the risk of postoperative complications in general surgery. However, use of the POSSUM is not absolutely suitable for open pancreaticoduodenectomy (OPD), which has unique complications such as pancreatic fistula formation. This study was performed to establish a new risk score for assessing the incidence of postoperative complications of OPD. Methods This retrospective case-control study involved 159 patients who underwent standard OPD from 2 January 2017 to 1 February 2019. The risk factors for post-OPD complications were statistically investigated, and a risk score model was established by multivariate logistic regression. Results Among all 159 patients, 72 (42.28%) developed complications. A scoring system was developed based on the following five independent variables: sodium concentration of <141.20 mmol/L, white blood cell count of >6.35 × 109/L, pancreatic texture grade, body mass index of >25.06 kg/m2, and basic respiratory diseases. Our risk score model demonstrated better discriminating power, prediction power, and prediction probability than the POSSUM model in the receiver operating characteristic curve analysis. Conclusion This novel risk score may help to predict postoperative complications after OPD with higher accuracy than the POSSUM system.
Integrated bioinformatic analysis of HNF1A in human cancers
Authors: Zhang Enfan , Huang Xi , He Jingsong 
Published: March 2021

Objectives Cancer is a threat to human health, and many molecules are involved in the transformation of malignant cells. Hepatocyte nuclear factor 1A (HNF1A) is an important transcription factor that regulates multiple biological processes. Our research focused on elucidating the expression and function of HNF1A in cancer through bioinformatic analysis. Methods UALCAN, Kaplan–Meier plotter, COSMIC, Tumor IMmune Estimation Resource, and Cancer Regulome were used to obtain relevant data for HNF1A. Results HNF1A was abnormally expressed in multiple cancers, and its expression was associated with differences in overall survival in patients with cancer. HNF1A mutations widely exist in tumors and interact with different genes involved in various processes. Additionally, we found that HNF1A was associated with the infiltration of immune cells, and it affected the prognostic value of these cells in some cancers. Conclusions HNF1A plays a crucial role in cancer, and it may represent a biomarker and target for future cancer immunotherapy.
Expression and potential role of CXCL5 in the pathogenesis of intrauterine adhesions
Authors: Fang Zi-Ang , He Yu , Sun Chao , Zhan Lei , Zhou Guiju , Wei Bing , Sun Shiying 
Published: March 2021

Objective C-X-C motif chemokine ligand 5 (CXCL5), a member of the chemokine family, is associated with remodeling of connective tissues. However, its role in formation of intrauterine adhesions (IUA) remains unclear. We aimed to investigate the expression and mechanism underlying the role of CXCL5 in IUA. Methods Expression of CXCL5 in IUA was detected by immunohistochemistry in a rat model of IUA and by real-time PCR and western blotting in patients with IUA. The protein levels of matrix metalloproteinase 9 (MMP9) and transcription factor p65 in human endometrial cells were assessed by western blotting after CXCL5 overexpression. Results Protein expression of CXCL5 was significantly decreased in the endometria of IUA rats compared with that of control and sham-operated rats. Real-time PCR and western blotting in patients with IUA showed similar results to those from the rat model. After overexpression, CXCL5 significantly upregulated expression of MMP9 and slightly upregulated expression of p65 in human endometrial cells. Conclusions CXCL5 plays an important role in IUA formation after endometrial injury. We propose a molecular mechanism to explain formation of IUA, including downregulation of MMP9 by low CXCL5 expression. These findings provide valuable information for the prevention and targeted therapy of IUA.
Safety and Efficacy of a Novel Intubating Laryngeal Mask during the recovery period following Supratentorial Tumour Surgery
Authors: Ling Xiaomei , Chen Xuemeng , Liu Gaowang , Ma Xianfeng , Xiao Ming , Xiao Pan , Wang Hongyan , Xiao Jinfang 
Published: March 2021

Objective To assess safety and efficacy of a novel intubation laryngeal mask airway (ILMA) during the recovery period following supratentorial tumour surgery. Methods Patients who underwent supratentorial tumour surgery at our centre from January 2012 to December 2016 were eligible for this prospective randomised, parallel group study. We developed a novel ILMA using closely fitting laryngeal masks (No. 4/5) with 7.0/7.5 mm endotracheal tubes (ETT) plus screw fixators and anti-pollution sleeves. Results In total, 100 patients were intubated with the novel ILMA and 100 the ETT. There were no differences between groups in haemodynamic variables, oxygen saturation, exhaled CO2, or bispectral index all recorded during the 72-hour recovery period. However, there were significantly fewer incidences of coughing, less fluid drainage and lower haemoglobin levels in surgical fluid in the ILMA group compared with the ETT group. Conclusion Our novel ILMA device was associated with reduced coughing, fluid drainage and blood in surgical drain during the recovery period following supratentorial tumour surgery.
Finding the Silver Lining: Aging Well Amongst Older Brazilian Women in the Post-Migration Context
Authors: Lucchese Stephanie Pedrotti , Bishop Susan , Guruge Sepali , Zanchetta Margareth Santos , Pirner Diane 
Published: March 2021

Study Background The aging population in Canada has been increasing steadily over the past 40 years, however, there is limited information about the meaning of aging well amongst older Brazilian women in Canada. Methods A Heideggerian interpretive phenomenology study was conducted to understand the meaning of aging well amongst older Brazilian women in the post-migration context living in the Greater Toronto Area (GTA) in Ontario, Canada. Results Eight older Brazilian women residing in the GTA were recruited through purposive and snowball sampling and participated in individual face-to-face interviews. Through data analysis and the incorporation of Heidegger’s four existentials of human existence, the themes that emerged were (a) Embracing being part of a mosaic, (b) Aging with grace, (c) Chasing your dreams and (d) Being a bridge and not a fence. The overarching theme was: Finding the silver lining: Aging well. Conclusion This study informs nursing practice, research and policy development to advance the health of older immigrant adults in Canada.
Resistance-guided treatment of Mycoplasma genitalium infection at a UK sexual health centre
Authors: Conway Ruairi JH , Cook Seamus , Malone Cassandra , Bone Simon , Hassan-Ibrahim Mohammed Osman , Soni Suneeta 
Published: March 2021

We evaluated the ResistancePlus® MG assay in providing macrolide resistance-guided treatment (RGT) for Mycoplasma genitalium infection at a UK sexual health centre. M. genitalium–positive samples from men with urethritis and women with pelvic inflammatory disease (PID) were tested for macrolide resistance–mediating mutations (MRMMs). MRMM-positive infections were given moxifloxacin 400 mg; otherwise 2 g azithromycin (1 g single dose and then 500 mg OD) was given. Among 57 M. genitalium–positive patients (32 men and 25 women), MRMMs were detected in 41/57 (72% [95% confidence interval (95% CI) 58–83%). Thirty-two of 43 patients given RGT attended for test of cure. Treatment failure rate was significantly lower at 1/32 (3%) than 10/37 (27%) before RGT ( n = 37 [men = 23 and women = 17]; p = 0.008). Treatment failure was lower in male urethritis (0/15 vs. 7/21 p = 0.027) but not in female PID. There was a trend of a shorter time to negative test of cure (TOC) in male urethritis (55.1 [95% 43.7–66.4] vs. 85.1 [95% CI CI 64.1–106.0] days, p = 0.077) but not in female PID. Macrolide resistance is higher than previous UK reports and higher than expected. RGT reduces overall treatment failure and is particularly beneficial in M. genitalium urethritis. Fluoroquinolone resistance will continue to rise with increasing fluoroquinolone use, and RGT is critical to direct appropriate azithromycin use and prevent overuse of moxifloxacin.