bluuebunny/crossref_metadata_2025_split huggingface dataset:
The heavy cost of kumbaya–understanding the survival implications of nascent venture ownership structure
Authors: Noack David , Miller Douglas R. , Guidice Rebecca 
Published: August 2021

PurposeThis paper brings in relevant entrepreneurial behavior theory to understand the ownership decisions founders make during the nascent stage of new venture creation, and how such decisions impact the viability of the firm.Design/methodology/approachThe authors examine the behavior and decision making of 137 lead founders during the nascent stage of new venture creation. Psychological ownership and environmental uncertainty are measured of lead founders when dividing up firm ownership among the founding team. Using a longitudinal approach, these nascent-stage decisions are then analyzed to understand the impact on the new venture one year later.FindingsCounter to prior research suggesting teams are better off with identical wages and ownership, the authors find such harmony (i.e. “kumbaya”) pursuit to be a detriment to new venture emergence. Specifically, this study finds that nascent ventures are better off with an unequal ownership split among the founding team members. These findings suggest that nascent firms with an unequal split are more likely to move beyond the nascent stage and launch a functional business.Research limitations/implicationsAlthough the results of this study offer a valuable contribution to lead founders and new businesses, the study looked at each startup independent of another and is therefore not able to draw any conclusions related to competitiveness.Practical implicationsLead founders and founding teams frequently divide ownership evenly among the founders. This paper shows that, while convenient, the decision to divide ownership equally can hamper a nascent firm as it moves toward the launch phase of the startup process. These results should motivate founders to think deeply regarding the ownership structure decision and, at the very least, consider the possible negative costs associated with the pursuit of founding team unity.Originality/valueWhile scholars have brought attention to the nascent stage, few have identified and analyzed the decisions that take place during this critical time of the new venture development process. Furthermore, even is less is known of the impact nascent decisions have on startup launch. This study sheds light on these areas.
Foam additive manufacturing technology: main characteristics and experiments for hull mold manufacturing
Authors: Paquet Elodie , Bernard Alain , Furet Benoit , Garnier Sébastien , Le Loch Sébastien 
Published: August 2021

Purpose
The purpose of this paper is to present a novel methodology to produce a large boat hull with a foam additive manufacturing (FAM) process. To respond to shipping market needs, this new process is being developed. FAM technology is a conventional three-dimensional (3D) printing process whereby layers are deposited onto a high-pressure head mounted on a six-axis robotic arm. Traditionally, molds and masters are made with computer numerical control (CNC) machining or finished by hand. Handcrafting the molds is obviously time-consuming and labor-intensive, but even CNC machining can be challenging for parts with complex geometries and tight deadlines.

Design/methodology/approach
The proposed FAM technology focuses on the masters and molds, that are directly produced by 3D printing. This paper describes an additive manufacturing technology through which the operator can create a large part and its tools using the capacities of this new FAM technology.

Findings
The study shows a comparison carried out between the traditional manufacturing process and the additive manufacturing process, which is illustrated through an industrial case of application in the manufacturing industry. This work details the application of FAM technology to fabricate a 2.5 m boat hull mold and the results show the time and cost savings of FAM in the fabrication of large molds.

Originality/value
Finally, the advantages and drawbacks of the FAM technology are then discussed and novel features such as monitoring system and control to improve the accuracy of partly printed are highlighted.
Engaging by releasing: an investigation of the consequences of team autonomy on work engagement
Authors: Palumbo Rocco 
Published: August 2021

PurposeTeam autonomy involves empowering employees to achieve greater control over organizational dynamics. Such empowerment may augment the employees’ vigor, dedication and absorption at work. However, there is limited evidence on the contents of the relationship between team autonomy and work engagement. This paper aims to fill in this gap, shedding light into the manifold implications of team autonomy on employees’ work engagement.Design/methodology/approachA serial mediation analysis was designed to collect evidence of the effects of team autonomy on work engagement. Drawing on self-determination theory, social comparison theory and social facilitation theory, team member-supervisor exchanges and organizational climate were contemplated in the analysis as mediating variables. An ordinary least square regression-based model relying on 5,000 bootstrap samples was implemented. The study focused on a large sample of Europeans employed in the manufacturing sector (n= 4,588).FindingsTeam autonomy had tiny, but statistically significant effects on work engagement. Good relationships between team members and supervisors positively mediated the effects of team autonomy on work engagement. Conversely, the organizational climate did not have a significant mediating role. A statistically significant serial mediation effect linked team autonomy and work engagement via team member-supervisor exchanges and organizational climate.Practical implicationsTeam autonomy contributes to increasing the employees’ vigor, dedication and absorption at work. The enhancement of team member-supervisor relationships fosters the engagement of team members who experience a greater autonomy at work. The effects of team autonomy on organizational climate are ambiguous and mediated by an improvement of the relationships between team members and supervisors.Originality/valueThe paper originally investigates the implications of team autonomy on work engagement, emphasizing the importance of social exchanges at work to realize the full potential of team autonomy.
Low‐intensity pulsed ultrasound prevents prolonged hypoxia‐induced cardiac fibrosis through HIF‐1α/DNMT3a pathway via a TRAAK‐dependent manner
Authors: Zhao Kun , Weng Liqing , Xu Tianhua , Yang Chuanxi , Zhang Jing , Ni Gehui , Guo Xiasheng , Tu Juan , Zhang Dong , Sun Wei , Kong Xiangqing 
Published: August 2021

AbstractHypoxia‐induced cardiac fibrosis is an important pathological process in cardiovascular disorders. This study aimed to determine whether low‐intensity pulsed ultrasound (LIPUS), a novel and safe apparatus, could alleviate hypoxia‐induced cardiac fibrosis, and to elucidate the underlying mechanisms. Hypoxia (1% O2) and transverse aortic constriction (TAC) were performed on neonatal rat cardiac fibroblasts and mice to induce cardiac fibrosis, respectively. LIPUS irradiation was applied for 20 minutes every 6 hours for a total of 2 times in vitro, and every 2 days from 1 week before surgery to 4 weeks after surgery in vivo. We found that LIPUS dose‐dependently attenuated hypoxia‐induced cardiac fibroblast phenotypic conversion in vitro, and ameliorated TAC‐induced cardiac fibrosis in vivo. Hypoxia significantly upregulated the nuclear protein expression of hypoxia‐inducible factor‐1α (HIF‐1α) and DNA methyltransferase 3a (DNMT3a). LIPUS pre‐treatment reversed the elevated expression of HIF‐1α, and DNMT3a. Further experiments revealed that HIF‐1α stabilizer dimethyloxalylglycine (DMOG) hindered the anti‐fibrotic effect of LIPUS, and hampered LIPUS‐mediated downregulation of DNMT3a. DNMT3a small interfering RNA (siRNA) prevented hypoxia‐induced cardiac fibrosis. Results also showed that the mechanosensitive protein‐TWIK‐related arachidonic acid‐activated K+ channel (TRAAK) messenger RNA (mRNA) expression was downregulated in hypoxia‐induced cardiac fibroblasts, and TAC‐induced hearts. TRAAK siRNA impeded LIPUS‐mediated anti‐fibrotic effect and downregulation of HIF‐1α and DNMT3a. Above results indicated that LIPUS could prevent prolonged hypoxia‐induced cardiac fibrosis through TRAAK‐mediated HIF‐1α/DNMT3a signalling pathway.
Detection of expanded‐spectrum cephalosporin hydrolysis by lateral flow immunoassay
Authors: Moguet Christian , Gonzalez Camille , Sallustrau Antoine , Gelhaye Stéphanie , Naas Thierry , Simon Stéphanie , Volland Hervé 
Published: August 2021

SummaryEarly detection of expanded‐spectrum cephalosporin (ESC) resistance is essential not only for an effective therapy but also for the prompt implementation of infection control measures to prevent dissemination in the hospital. We have developed and validated a lateral flow immunoassay (LFIA), called LFIA‐CTX test, for the detection of ESC (cefotaxime) hydrolytic activity based on structural discrimination between the intact antibiotic and its hydrolysed product. A single bacterial colony was suspended in an extraction buffer containing cefotaxime. After a 30‐min incubation, the solution is loaded on the LFIA for reading within 10 min. A total of 348 well‐characterized Gram‐negative isolates were tested. Among them, the 38 isolates that did not express any cefotaxime‐hydrolysing β‐lactamase gave negative results. Of the 310 isolates expressing at least one cefotaxime‐hydrolysing β‐lactamase, all were tested positive, except three OXA‐48‐like producers, which were repeatedly detected negative. Therefore, the sensitivity was 99.1% and the specificity was 100%. The LFIA‐CTX test is efficient, fast, low‐cost and easy to implement in the workflow of a routine microbiology laboratory.
Ethics and standards in the use of artificial intelligence in medicine on behalf of the Royal Australian and New Zealand College of Radiologists
Authors: Kenny Lizbeth M , Nevin Mark , Fitzpatrick Kirsten 
Published: August 2021

AbstractIntroductionThe Royal Australian and New Zealand College of Radiologists (RANZCR) led the medical community in Australia and New Zealand in considering the impact of machine learning and artificial intelligence (AI) in health care. RANZCR identified that medical leadership was largely absent from these discussions, with a notable absence of activity from governments in the Australasian region up to 2019. The clinical radiology and radiation oncology sectors were considered ripe for the adoption of AI, and this raised a range of concerns about how to ensure the ethical application of AI and to guide its safe and appropriate use in our two specialties.MethodsRANZCR’s Artificial Intelligence Committee undertook a landscape review in 2019 anddetermined that AI within clinical radiology and radiation oncology had the potential to grow rapidly and significantly impact the professions. In order to address this, RANZCR drafted ethical principles on the use of AI and standards to guide deployment and engaged in extensive stakeholder consultation to ensure a range of perspectives were received and considered.ResultsRANZCR published two key bodies of work: The Ethical Principles of Artificial Intelligence in Medicine, and the Standards of Practice for Artificial Intelligence in Clinical Radiology.ConclusionRANZCR’s publications in this area have established a solid foundation to prepare for the application of AI, however more work is needed. We will continue to assess the evolution of AI and ML within our professions, strive to guide the upskilling of clinical radiologists and radiation oncologists, advocate for appropriate regulation and produce guidance to ensure that patient care is delivered safely.
Taxation and market power in the legal marijuana industry
Authors: Hollenbeck Brett , Uetake Kosuke 
Published: August 2021

AbstractWe study tax and regulatory policy in the legal marijuana market using unique administrative data from Washington state. Washington's retail entry restrictions have resulted in firms with substantial market power who behave like local monopolists. We show how the presence of market power causes tax and regulatory policy recommendations to differ from standard models that assume perfect competition. Combining structural demand models with measured pass‐through, we show that marijuana is not overtaxed at 37% but is still on the upward sloping region of the Laffer curve and that these taxes have high social costs and are mainly borne by consumers.
Genotypes and phenotypes of methicillin‐resistant staphylococci isolated from shrimp aquaculture farms
Authors: Rajan Vineeth , Sivaraman Gopalan Krishnan , Vijayan Ardhra , Elangovan Ravikrishnan , Prendiville Alison , Bachmann Till T. 
Published: August 2021

SummaryThe population of methicillin‐resistant (MR) staphylococci in aquatic environment is rarely investigated. Here, we characterized a collection of MR staphylococci recovered from shrimp aquaculture farms (n = 37) in Kerala, India. A total of 261 samples yielded 47 MR isolates (16 S. aureus, 13 S. haemolyticus, 11 S. epidermidis, 3 S. saprophytics and 2 each of S.intermedius and S. kloosii). Multi‐drug resistance was evident in 72.3% of the isolates, with resistance mainly towards erythromycin (78.7%), norfloxacin and trimethoprim‐sulfamethoxazole (53.2%), and gentamicin (34%). Major resistance genes identified included mecA (100%), ermC (38.3%), aacA‐aphD (21.3%), tetK (14.9%) and tetM (21.3%). Almost 60% of the isolates carried type V SCCmec (Staphylococcal Cassette Chromosome mec), and the remaining harboured untypeable SCCmec elements. Comprehensive genotyping of the methicillin‐resistant Staphylococcus aureus isolates revealed high prevalence of ST772‐t345‐V (sequence type‐spa type‐SCCmec type) (75%), followed by minor representations of ST6657‐t345‐V and ST3190‐t12353. The isolates of S. haemolyticus and S. epidermidis were genotypically diverse as shown by their pulsed‐field gel electrophoresis (PFGE) profiles. Genes encoding staphylococcal enterotoxins were observed in 53.2% of the isolates. Various genes involved in adhesion and biofilm formation were also identified. In conclusion, our findings provide evidence that shrimp aquaculture settings can act as reservoirs of methicillin‐resistant staphylococci.
A Canadian Perspective on Indigenous Peoples and Accounting Research: Using a Systematic Literature Review to Promote Inquiry and Inclusion*
Authors: Lento Camillo , Butt Irfan , Bujaki Merridee , Anderson Nathaniel , Ogima Cheryl 
Published: August 2021

ABSTRACTThis study uses a systematic literature review to explore academic research at the intersection of accounting and Indigenous peoples, focusing on the Canadian context. We systematically identified 15 English‐language, peer‐reviewed articles published in the review period of 1979–2019. We conducted detailed content and thematic analysis of the articles. Overall, we noted that research in this area is based upon archival documents or reviews of prior literature rather than qualitative or survey research methods. We found that much of the research has been driven by a small network of scholars, focusing primarily on themes of governmentality, imperialism, and accountability and control. In addition, research on Indigenous peoples and accounting in Canada has slowed over the past decade, which is inconsistent with global trends. Based on the systematic literature review, we offer specific, actionable recommendations to support inquiry and inclusion in the area of accounting and Indigenous peoples to move both research and society forward toward reconciliation. Our detailed recommendations aim to advance our understanding of the relationship between accounting and Indigenous peoples, foster an understanding of accountability issues relevant to Indigenous peoples in the Canadian accounting context, enhance support for Indigenous peoples studying business and accounting, and encourage Indigenous peoples to consider careers in accounting.
Aging influences the cardiac macrophage phenotype and function during steady state and during inflammation
Authors: Esfahani Noushin Saljoughian , Wu Qian , Kumar Naresh , Ganesan Latha Prabha , Lafuse William P. , Rajaram Murugesan V. S. 
Published: August 2021

AbstractAging‐mediated immune dysregulation affects the normal cardiac immune cell phenotypes and functions, resulting in cardiac distress. During cardiac inflammation, immune activation is critical for mounting the regenerative responses to maintain normal heart function. We investigated the impact of aging on myeloid cell phenotype and function during cardiac inflammation induced by a sub‐lethal dose of LPS. Our data show that hearts of old mice contain more myeloid cells than the hearts of young mice. However, while the number of monocytic‐derived suppressor cells did not differ between young and old mice, monocytic‐derived suppressor cells from old mice were less able to suppress T‐cell proliferation. Since cardiac resident macrophages (CRMs) are important for immune surveillance, clearance of dead cells, and tissue repair, we focused our studies on CRMs phenotype and function during steady state and LPS treatment. In the steady state, we observed significantly more MHC‐IIlow and MHC‐IIhigh CRMs in the hearts of old mice; however, these populations were decreased in both young and aged mice upon LPS treatment and the decrease in CRM populations correlated with defects in cardiac electrical activity. Notably, mice treated with a liver X receptor (LXR) agonist showed an increase in MerTK expression in CRMs of both young and old mice, which resulted in the reversal of cardiac electrical dysfunction caused by lipopolysaccharide (LPS). We conclude that aging alters the phenotype of CRMs, which contributes to the dysregulation of cardiac electrical dysfunction during infection in aged mice.
Association of alcohol and other substance‐related diagnoses with severe maternal morbidity
Authors: Courchesne Natasia S. , Smith Laramie R. , Zúñiga María Luisa , Chambers Christina D. , Reed Mark B. , Ballas Jerasimos , Marienfeld Carla B. 
Published: August 2021

AbstractBackgroundPregnant women with a substance‐related diagnosis, such as an alcohol use disorder, are a vulnerable population that may experience higher rates of severe maternal morbidity, such as hemorrhage and eclampsia, than pregnant women with no substance‐related diagnosis.MethodsThis retrospective cross‐sectional study reviewed electronic health record data on women (aged 18–44 years) who delivered a single live birth or stillbirth at ≥ 20 weeks of gestation from March 1, 2016, to August 30, 2019. Women with and without a substance‐related diagnosis were matched on key demographic characteristics, such as age, at a 1:1 ratio. Adjusting for these covariates, odds ratios and 95% confidence intervals were calculated.ResultsA total of 10,125 deliveries met the eligibility criteria for this study. In the matched cohort of 1,346 deliveries, 673 (50.0%) had a substance‐related diagnosis, and 94 (7.0%) had severe maternal morbidity. The most common indicators in women with a substance‐related diagnosis included hysterectomy (17.7%), eclampsia (15.8%), air and thrombotic embolism (11.1%), and conversion of cardiac rhythm (11.1%). Having a substance‐related diagnosis was associated with severe maternal morbidity (adjusted odds ratio = 1.81 [95% CI, 1.14–2.88], p‐value = 0.0126). In the independent matched cohorts by substance type, an alcohol‐related diagnosis was significantly associated with severe maternal morbidity (adjusted odds ratio = 3.07 [95% CI, 1.58–5.95], p‐value = 0.0009), while the patterns for stimulant‐ and nicotine‐related diagnoses were not as well resolved with severe maternal morbidity and opioid‐ and cannabis‐related diagnoses were not associated with severe maternal morbidity.ConclusionWe found that an alcohol‐related diagnosis, although lowest in prevalence of the substance‐related diagnoses, had the highest odds of severe maternal morbidity of any substance‐related diagnosis assessed in this study. These findings reinforce the need to identify alcohol‐related diagnoses in pregnant women early to minimize potential harm through intervention and treatment.
Evaluating effects of sex and age on white matter microstructural alterations in alcohol use disorder: A diffusion tensor imaging study
Authors: Kisner Mallory A. , Sussman Lauren , Manuweera Thushini , Grodin Erica N. , Fede Samantha J. , Sarlls Joelle E. , Momenan Reza 
Published: August 2021

AbstractBackgroundAlterations in white matter microstructure associated with chronic alcohol use have been demonstrated in previous diffusion tensor imaging (DTI) research. However, there is conflicting evidence as to whether such differences are influenced by an individual's biological sex. The purpose of the present study was to investigate the prevalence of sex differences in the white matter microstructure of the brains of individuals with alcohol use disorder (AUD) and healthy controls.MethodsOne hundred participants with AUD (38 female, aged 21 to 68) participating in the National Institute on Alcohol Abuse and Alcoholism’s inpatient treatment program and 98 healthy control participants (52 female) underwent a diffusion‐weighted scan. Images collected were processed for each subject individually, and voxelwise, tract‐based spatial statistics analysis was conducted to test for differences in the DTI measures of fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD).ResultsA 2‐way, between‐subjects ANCOVA that tested for differences by group and sex revealed widespread differences between AUD and control subjects, but no interaction between group and sex. Additional analyses exploring demographic and alcohol use variables showed significant impacts of age on white matter microstructure that were more pronounced in individuals with AUD. Plots of FA by age, sex, and group in major white matter tracts suggest a need to explore higher order interactions in larger samples.ConclusionsThese results bolster recent findings of similar microstructural properties in men and women with AUD but provide a rationale for the consideration of age when investigating the impacts of chronic alcohol use on the brain's white matter.