bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a Brazilian cardioprotective diet and nuts on cardiometabolic parameters after myocardial infarction: study protocol for a randomized controlled clinical trial
Authors: Marcadenti Aline , Weber Bernardete , Bersch-Ferreira Angela Cristine , Machado Rachel Helena Vieira , Torreglosa Camila Ragne , de Sousa Lara Enilda Maria , da Silva Lucas Ribeiro , Santos Renato Hideo Nakagawa , Miyada Debora Harumi Kodama , Sady Erica Regina Ribeiro , Costa Rosana Perim , Piegas Leopoldo , de Abreu-Silva Erlon Oliveira , de Quadros Alexandre Schaan , Weschenfelder Camila , dos Santos Júlia Lorenzon , Souza Gabriela Corrêa , Parahiba Suena Medeiros , Fayh Ana Paula Trussardi , Bezerra Danielle Soares , Carvalho Ana Paula Perillo Ferreira , Machado Malaine Morais Alves , Vasconcelos Sandra Mary Lima , Araújo Jéssika , de Figueiredo Neto José Albuquerque , Dias Luciana Pereira Pinto , Nagano Francisca Eugenia Zaina , de Almeida Cássia Cristina Paes , Moreira Annie Seixas Bello , Gapanowicz Débora Pinto , Purgatto Eduardo , Rogero Marcelo Macedo , Sampaio Geni Rodrigues , da Silva Torres Elizabeth Aparecida Ferraz , Duarte Graziela Biude Silva , Cavalcanti Alexandre Biasi 
Published: September 2021

Abstract
Background
Nut consumption has been related to improvements on cardiometabolic parameters and reduction in the severity of atherosclerosis mainly in primary cardiovascular prevention. The objective of this trial is to evaluate the effects of the Brazilian Cardioprotective Diet (DIetaCArdioprotetoraBrasileira, DICA Br) based on consumption of inexpensive locally accessible foods supplemented or not with mixed nuts on cardiometabolic features in patients with previous myocardial infarction (MI).

Methods
DICA-NUTS study is a national, multicenter, randomized 16-week follow-up clinical trial. Patients over 40 years old with diagnosis of previous MI in the last 2 to 6 months will be recruited (n = 388). A standardized questionnaire will be applied to data collection and blood samples will be obtained. Patients will be allocated in two groups: Group 1: DICA Br supplemented with 30 g/day of mixed nuts (10 g of peanuts, 10 g of cashew, 10 g of Brazil nuts); and Group 2: only DICA Br. The primary outcome will consist of LDL cholesterol means (in mg/dL) after 16 weeks of intervention. Secondary outcomes will consist of other markers of lipid profile, glycemic profile, and anthropometric data.

Discussion
It is expected that DICA Br supplemented with mixed nuts have superior beneficial effects on cardiometabolic parameters in patients after a MI, when compared to DICA Br.

Trial registration
ClinicalTrials.gov Identifier NCT03728127. First register: November 1, 2018; Last update: June 16, 2021. World Health Organization Universal Trial Number (WHO-UTN): U1111-1259-8105.
Effect of posture on pulmonary function and oxygenation after fast-tracking video-assisted thoracoscopic surgery (VATS) lobectomy: a prospective pilot study
Authors: Huang Lin , Kehlet Henrik , Petersen René Horsleben 
Published: September 2021

Abstract
Background
Minimally invasive surgery combined with enhanced recovery programmes has improved outcomes after lung cancer surgery and where early mobilisation may be an important factor. However, little is known about pulmonary function and oxygenation during mobilisation after video-assisted pulmonary lobectomy. The aim of this prospective pilot cohort study was to explore the effect of postural changes (from supine to sitting to standing) on pulmonary function and oxygen saturation in a well-defined enhanced recovery programmes setting after video-assisted thoracoscopic surgery lobectomy.

Methods
A total of 24 patients were evaluated daily for postoperative pain score, pulmonary function (forced expiratory volume 1 s) and oxygen saturation in supine, sitting and standing position from 6 h after surgery to 6 h after chest drain removal.

Results
Mobilisation from supine to standing position showed a significant 7.9% increase (p = 0.04) in forced expiratory volume in 1 s percentage and oxygen saturation about 1.8% (p< 0.001) without increasing pain (p = 0.809).

Conclusions
Early mobilisation should be encouraged to enhance recovery after video-assisted thoracoscopic surgery lobectomy by increasing lung function and oxygen delivery.

Trial registration
• Name of the registry: clinicaltrials.gov
• Trial registration number: NCT04508270
• Date of registration: August 11, 2020
Influence of osmolality on gastrointestinal fluid volume and drug absorption: potential impact on oral salt supplementation
Authors: Takemura Miyuki , Tanaka Yuki , Inoue Katsuhisa , Tamai Ikumi , Shirasaka Yoshiyuki 
Published: September 2021

Abstract
Background
The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is the most frequent cause of hyponatremia in patients with cerebrovascular disease, and is often treated with oral salt tablets. However, we have shown that osmolality-dependent variations in gastrointestinal (GI) fluid volume can alter the concentration of a poorly permeable drug in the GI tract, potentially affecting its absorption. Here, we examined the effect of ingestion of hyperosmotic solution (10% NaCl) on drug concentration and absorption in the GI tract.

Methods
The effects of osmolality on luminal fluid volume and drug absorption in rat intestine (jejunum, ileum and colon) were examined by means of an in situ closed loop method using fluorescein isothiocyanate-dextran 4000 (FD-4) and atenolol. In vivo absorption in rats was determined by measuring the plasma concentration after oral administration of the test compounds dissolved in purified water or hyperosmotic solution (10% NaCl).

Results
Administration of hyperosmotic solution directly into the GI tract significantly increased the GI fluid volume, owing to secretion of water into the lumen. After administration in hyperosmotic solution, the luminal concentration of non-permeable FD-4 was significantly lower than the initial dosing concentration, whereas after administration in purified water, the luminal concentration exceeded the initial concentration. The fraction absorbed of atenolol was markedly lower after administration in hyperosmotic solution than after administration in purified water. An in vivo pharmacokinetic study in rats was consistent with these findings.

Conclusions
Administration of hyperosmotic NaCl solution increased GI fluid volume and reduced the plasma level of orally administered atenolol. This may imply that oral salt tablets used to treat hyponatremia in SIADH patients could decrease the intestinal absorption of concomitantly administered drugs, resulting in lower plasma exposure.
Long-Term Report of a Comprehensive Molecular and Genomic Analysis in NRG Oncology/RTOG 0424: A Phase II Study of Radiation and Temozolomide in High-Risk Grade II Glioma
Authors: Fleming Jessica L. , Pugh Stephanie L. , Fisher Barbara J. , Lesser Glenn J. , Macdonald David R. , Bell Erica H. , McElroy Joseph P. , Becker Aline P. , Timmers Cynthia D. , Aldape Kenneth D. , Rogers C. Leland , Doyle Thomas J. , Werner-Wasik Maria , Bahary Jean-Paul , Yu Hsiang-Hsuan Michael , D'Souza David P. , Laack Nadia N. , Sneed Penny K. , Kwok Young , Won Minhee , Mehta Minesh P. , Chakravarti Arnab 
Published: September 2021

PURPOSE This study sought to determine the prognostic significance of the WHO-defined glioma molecular subgroups along with additional alterations, including MGMT promoter methylation and mutations in ATRX, CIC, FUBP1, TERT, and TP53, in NRG/RTOG 0424 using long-term follow-up data. METHODS Mutations were determined using an Ion Torrent sequencing panel. 1p/19q co-deletion and MGMT promoter methylation were determined by Affymetrix OncoScan and Illumina 450K arrays. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method and tested using the log-rank test. Hazard ratios were calculated using the Cox proportional hazard model. Multivariable analyses (MVAs) included patient pretreatment characteristics. RESULTS We obtained complete molecular data to categorize 80/129 eligible patients within the WHO subgroups. Of these, 26 (32.5%) were IDHmutant/co-deleted, 28 (35%) were IDHmutant/non-co-deleted, and 26 (32.5%) were IDHwild-type. Upon single-marker MVA, both IDHmutant subgroups were associated with significantly better OS and PFS ( P values < .001), compared with the IDHwild-type subgroup. MGMT promoter methylation was obtained on 76 patients, where 58 (76%) were methylated and 18 (24%) were unmethylated. Single-marker MVAs demonstrated that MGMT promoter methylation was statistically significant for OS ( P value < .001) and PFS ( P value = .003). In a multimarker MVA, one WHO subgroup comparison ( IDHmutant/co-deleted v IDHwild-type) was significant for OS ( P value = .045), whereas MGMT methylation did not retain significance. CONCLUSION This study reports the long-term prognostic effect of the WHO molecular subgroups, MGMT promoter methylation, and other mutations in NRG/RTOG 0424. These results demonstrate that the WHO molecular classification and MGMT both serve as strong prognostic indicators, but that MGMT does not appear to add statistically significant prognostic value to the WHO subgrouping, above and beyond IDH and 1p/19q status.
Rate of Gestational Weight Gain and Glucose-Insulin Metabolism Among Hispanic Pregnant Women With Overweight and Obesity
Authors: Lindsay Karen L , Gyllenhammer Lauren E , Entringer Sonja , Wadhwa Pathik D 
Published: September 2021

Abstract

Context
Hispanic women are at elevated risk of gestational glucose intolerance and postpartum type 2 diabetes compared with non-Hispanic White women. Identification of potentially modifiable factors contributing to this trajectory of beta-cell dysfunction is warranted.

Objective
We aimed to determine the association between rate of gestational weight gain (rGWG) and glucose-insulin metabolism in Hispanic pregnant women with overweight and obesity.

Methods
This cross-sectional, observational study, conducted from 2018-2020 at the clinical research center at University of California, Irvine, included 33 nondiabetic Hispanic pregnant women at 28 to 30 weeks’ gestation with pre-pregnancy body mass index (BMI) 25.0 to 34.9 kg/m2. Participants consumed a standardized liquid mixed meal after an overnight fast. Serial blood samples were collected at fasting and up to 2 hours postprandial. The glucose and insulin area under the curve (AUC), insulin sensitivity index (ISI) and insulin secretion sensitivity index (ISSI)-2 were computed.

Results
Average rGWG (0.36 ± 0.22 kg/week) was classified as excessive in 60% of women. While rGWG was not associated with the glucose or insulin AUC or ISI, it accounted for 13.4% of the variance in ISSI-2 after controlling for covariates (maternal age, parity, and pre-pregnancy BMI); for each 1 unit increase in rGWG, ISSI-2 decreased 2.1 units (P = 0.015).

Conclusion
Even in the absence of gestational diabetes, rGWG was inversely associated with beta-cell function in a high-risk population of Hispanic pregnant women with overweight and obesity. Beta-cell decline is an established risk factor for transition to type 2 diabetes, and these cross-sectional findings highlight rGWG as a potentially modifiable contributor to this process.
Approach to Neurologic Infections
Authors: Berkowitz Aaron L. 
Published: September 2021

ABSTRACT

PURPOSE OF REVIEW
This article provides an overview of the clinical approach to the diagnosis of neurologic infections, focusing on the symptoms, signs, imaging features, and laboratory findings of the major categories of neuroinfectious diseases.

RECENT FINDINGS
The increased use of immunosuppressive and immunomodulatory therapy to treat autoimmune diseases has led to an increase in opportunistic neurologic infections. The description of numerous causes of autoimmune antibody–mediated encephalitis over the past decade has expanded the differential diagnosis of encephalitis beyond infection. The emergence of metagenomic next-generation sequencing has led to diagnoses of rare or unexpected causes of neurologic infections and has the potential to enhance diagnostic precision in neuroinfectious diseases.

SUMMARY
Infections of the nervous system can affect any level of the neuraxis and present over any time course. Neurologic infections may present atypically with respect to clinical, radiologic, and CSF analysis features in immunocompromised patients or older adults. A thorough evaluation including systemic features, past medical history, travel, exposures, detailed examination, neuroimaging, and CSF analysis is often necessary to make a definitive diagnosis. It is important to be aware of the test characteristics and limitations of microbiological tests on CSF for neurologic infections to avoid being misled by false positives or false negatives.
Neurologic Complications of Lyme Disease
Authors: Roos Karen L. 
Published: September 2021

ABSTRACT

PURPOSE OF REVIEW
This article reviews the symptomatology, diagnosis, and treatment of neuroborreliosis.

RECENT FINDINGS
The most recent guidelines for the diagnosis and treatment of Lyme disease were published in 2020 by the Infectious Diseases Society of America, the American Academy of Neurology, and the American College of Rheumatology.

SUMMARY
The most common neurologic complications of Lyme disease are cranial neuritis (most often a unilateral or bilateral facial nerve palsy), meningitis, and radiculoneuritis/mononeuropathy multiplex. Testing for Lyme disease begins with an enzyme-linked immunosorbent assay (ELISA). If the ELISA is positive or borderline, Western blots should be performed for both IgM and IgG antibodies. As a general rule, in infectious diseases, an IgM antibody response is followed by an IgG antibody response. A central nervous system infection has either a CSF pleocytosis or pathogen-specific intrathecal antibody production. Lyme meningitis, cranial neuropathy, radiculoneuropathy, or other peripheral nervous system manifestations are treated with oral doxycycline or IV ceftriaxone, cefotaxime, or penicillin G. No additional antibiotic therapy is indicated for patients with posttreatment Lyme disease syndrome or patients with concern for chronic Lyme disease with no evidence of previous or current Lyme infection.
Meningitis
Authors: Aksamit Allen J. , Berkowitz Aaron L. 
Published: September 2021

ABSTRACT

PURPOSE OF REVIEW
This article reviews the diagnosis and treatment of infectious meningitis, including updates on newer molecular diagnostic techniques for microbiological diagnosis.

RECENT FINDINGS
New polymerase chain reaction (PCR)-based molecular diagnostic techniques have improved the timeliness of microbiological diagnosis in meningitis, but clinicians must be aware of the limitations of such tests. Next-generation sequencing can now be applied to CSF, allowing for diagnosis of infections not identifiable by conventional means.

SUMMARY
Infectious meningitis can be caused by a broad range of organisms. The clinician must be aware of the test characteristics of new molecular techniques for microbiological diagnosis as well as traditional techniques to tailor antimicrobial therapy appropriately in patients with meningitis.
Effective Dose of Prophylactic Oxytocin Infusion During Cesarean Delivery in 90% Population of Nonlaboring Patients With Preeclampsia Receiving Magnesium Sulfate Therapy and Normotensives: An Up-Down Sequential Allocation Dose-Response Study
Authors: Tyagi Asha , Mohan Aparna , Singh Yuvraj , Luthra Ankit , Garg Devansh , Malhotra Rajeev Kumar 
Published: September 2021

BACKGROUND:
Oxytocin administration during cesarean delivery is the first-line therapy for the prevention of uterine atony. Patients with preeclampsia may receive magnesium sulfate, a drug with known tocolytic effects, for seizure prophylaxis. However, no study has evaluated the minimum effective dose of oxytocin during cesarean delivery in women with preeclampsia.

METHODS:
This study compared the effective dose in 90% population (ED90) of oxytocin infusion for achieving satisfactory uterine tone during cesarean delivery in nonlaboring patients with preeclampsia who were receiving magnesium sulfate treatment with a control group of normotensives who were not receiving magnesium sulfate. This prospective dual-arm dose-finding study was based on a 9:1 biased sequential allocation design. Oxytocin infusion was initiated at 13 IU/h, on clamping of the umbilical cord, in the first patient of each group. Uterine tone was graded as satisfactory or unsatisfactory by the obstetrician at 4 minutes after initiation of oxytocin infusion. The dose of oxytocin infusion for subsequent patients was decided according to the response exhibited by the previous patient in the group; it was increased by 2 IU/h after unsatisfactory response or decreased by 2 IU/h or maintained at the same level after satisfactory response, in a ratio of 1:9. Oxytocin-associated side effects were also evaluated. Dose-response data for the groups were evaluated using a log-logistic function and ED90 estimates were derived from fitted equations using the delta method.

RESULTS:
The ED90 of oxytocin was significantly greater for the preeclampsia group (n = 27) than for the normotensive group (n = 40) (24.9 IU/h [95% confidence interval {CI}, 22.4–27.5] and 13.9 IU/h [95% CI, 12.4–15.5], respectively); the difference in dose requirement was 10.9 IU/h (95% CI, 7.9–14.0; P < .001). The number of patients with oxytocin-related hypotension, defined as a decrease in systolic blood pressure >20% from baseline or to <90 mm Hg, was significantly greater in the preeclampsia group (92.6% vs 62.5%; P = .030), while other side effects such as ST-T depression, nausea/vomiting, headache, and flushing, were not significantly different. There was no significant difference in the need for additional uterotonic or uterine massage, estimated blood loss, and need for re-exploration for uncontrolled bleeding.

CONCLUSIONS:
Patients with preeclampsia receiving preoperative magnesium therapy need a greater intraoperative dose of oxytocin to achieve satisfactory contraction of the uterus after fetal delivery, as compared to normotensives.
Singlewomen and Illicit Pregnancy in Late Medieval France
Authors: McDougall Sara 
Published: September 2021

AbstractThis article examines the consequences of extramarital pregnancy for women in late medieval France. Pregnancy outside marriage is typically thought of as a disaster for women and children alike and for their families. However, careful analysis of records of royal pardon, other legal and prescriptive sources, and a wide range of other materials all suggests otherwise. The article demonstrates that, at least for some single mothers in late medieval France, illicit pregnancy did not necessarily mean disaster at all. Pregnant women could help themselves, and were helped by others. All this has important implications for our understanding of the regulation of sexuality and reproduction in late medieval France, and of the role of mercy in medieval justice.Cet article examine les conséquences des grossesses illicites pour les mères célibataires dans le Nord de la France à la fin du Moyen Age. La grossesse hors mariage est traditionnellement considérée comme une catastrophe pour les mères et les enfants, ainsi que pour leurs familles. Une analyse des documents relatifs à la grâce royale, d'autres sources juridiques et normatives et d'un large éventail d'autres documents suggère tout le contraire. L'article montre que, du moins pour certaines mères célibataires de la France médiévale tardive, une grossesse illicite ne signifie pas nécessairement une catastrophe. Les mères pouvaient s'aider elles-mêmes et étaient aidées par d'autres. Cette conclusion a des implications importantes pour la réglementation de la sexualité et de la reproduction, et pour le rôle de la miséricorde dans la justice médiévale.
ПРОБЛЕМЫ КАДРОВОГО ПЛАНИРОВАНИЯ В РОССИЙСКИХ КОМПАНИЯХ И ИНСТРУМЕНТЫ ИХ УСТРАНЕНИЯ
Authors: Demidova Elena V. 
Published: September 2021

Автор статьи исходит из того, что кадровое планирование играет решающую роль в реализации стратегии кадровой политики предприятия, способствует ее воплощению через соответствующие мероприятия. Комплектование современными кадрами всех подразделений предприятия невозможно без четкого планирования персонала, которое согласуется с производственными, финансовыми планами, планами научно-исследовательских работ и другими планами предприятия.
В силу того, что система планирования на предприятии включает в себя системную работу по разработке планов - стратегического плана, долговременного плана, текущих и оперативных планов, то особое внимание следует уделить стратегическому плану, который являясь основополагающим, определяет главные цели предприятия на 10-15 лет вперед, нацелен на долговременное решение вопросов стратегии предприятия. В отличие от него, текущее планирование увязывает все направления деятельности предприятия и работу функциональных служб предприятия, в том числе и службу управления персоналом, однако не является определяющим в перспективном развитии бизнеса.
Практические работники отмечают, что тенденцией развития бизнеса последнего времени стало признание и понимание факта взаимосвязи эффективности кадрового планирования с эффективностью самой организации, в отличие от устаревших взглядов об исключительно закрытии кадровой потребности данной функцией [16, с. 11].
Актуальность и новизна работы определяется тем, что формирование и совершенствование эффективной системы кадрового планирования как предпосылки поступательного развития предприятия выступает базой для определения дальнейших путей изучения данного института на современном этапе, с экстраполяцией результатов на будущее время. Предложенные рекомендации по развитию кадрового планирования на основе передовых международных кадровых технологий позволят преодолеть недостатки существующих моделей их функционирования.
Цель – разработка рекомендаций по решению наиболее распространенных вопросов совершенствования кадрового планирования на предприятии с учетом последних тенденций HR-технологий.
Метод или методология проведения работы: в статье использовались общенаучные методы, а также метод экспертных оценок, метод скорректированной экстраполяции планирования персонала.
Результаты: получена модель развития инструментов кадрового планирования с привязкой к стратегии развития предприятия.
Область применения результатов: полученные результаты возможно применять на производственных предприятиях и организациях.
Ceramic supplier selection using analytical hierarchy process method
Authors: Rahmiati Filda , Syafei H.M Yani , Purwanto Purwanto , Andianto Jonathan 
Published: September 2021

This study tried to implement the Analytical Hierarchy Process (AHP) and the weights of the criteria and sub-criteria to find the best supplier. According to QCDFR (quality, cost, delivery, flexibility, and responsiveness). This study took place in one of the biggest tile producers, ranks fifth in the world and the first in Indonesia. However, the company currently only uses quality, cost, and delivery methods to choose the best supplier of raw material, namely feldspar. This research tries to use the systematic method to find the best supplier based on the importance of the criteria. The method used the quantitative approach to enumerate the data to analyze the information. The company analyzed six suppliers. The primary tool used in this research is a Super Decision Software version 3.2 to create and manage the AHP model, enter the judgments, get results, and perform sensitivity analysis on the results. The result found that Semarang is the best supplier. The company will choose Semarang to become the company's business partner compared to the other suppliers because Semarang has met the criteria that the company prioritizes the most. By having the best supplier selection, the company can provide the right material consistency and suitable material suitability.