bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decreased Glucagon-Like Peptide-1 Is Associated With Calcific Aortic Valve Disease: GLP-1 Suppresses the Calcification of Aortic Valve Interstitial Cells
Authors: Xiao Fan , Zha Qing , Zhang Qianru , Wu Qihong , Chen Zhongli , Yang Ying , Yang Ke , Liu Yan 
Published: August 2021

Objectives: This study explores the concentration and role of glucagon-like peptide-1 (GLP-1) in calcific aortic valve disease (CAVD).Background: Calcific aortic valve disease is a chronic disease presenting with aortic valve degeneration and mineralization. We hypothesized that the level of GLP-1 is associated with CAVD and that it participates in the calcification of aortic valve interstitial cells (AVICs).Methods: We compared the concentration of GLP-1 between 11 calcific and 12 normal aortic valve tissues by immunohistochemical (IHC) analysis. ELISA was used to measure GLP-1 in serum of the Control (n = 197) and CAVD groups (n = 200). The effect of GLP-1 on the calcification of AVICs and the regulation of calcific gene expression were also characterized.Results: The GLP-1 concentration in the calcific aortic valves was 39% less than that in the control non-calcified aortic valves. Its concentration in serum was 19.3% lower in CAVD patients. Multivariable regression analysis demonstrated that GLP-1 level was independently associated with CAVD risk. In vitro, GLP-1 antagonized AVIC calcification in a dose- and time-dependent manner and it down-regulated RUNX2, MSX2, BMP2, and BMP4 expression but up-regulated SOX9 expression.Conclusions: A reduction in GLP-1 was associated with CAVD, and GLP-1 participated in the mineralization of AVICs by regulating specific calcific genes. GLP-1 warrants consideration as a novel treatment target for CAVD.
Solar Cycle-Modulated Deformation of the Earth–Ionosphere Cavity
Authors: Bozóki Tamás , Sátori Gabriella , Williams Earle , Mironova Irina , Steinbach Péter , Bland Emma C. , Koloskov Alexander , Yampolski Yuri M. , Budanov Oleg V. , Neska Mariusz , Sinha Ashwini K. , Rawat Rahul , Sato Mitsuteru , Beggan Ciaran D. , Toledo-Redondo Sergio , Liu Yakun , Boldi Robert 
Published: August 2021

The Earth–ionosphere cavity resonator is occupied primarily by the electromagnetic radiation of lightning below 100 Hz. The phenomenon is known as Schumann resonances (SR). SR intensity is an excellent indicator of lightning activity and its distribution on global scales. However, long-term measurements from high latitude SR stations revealed a pronounced in-phase solar cycle modulation of SR intensity seemingly contradicting optical observations of lightning from satellite, which do not show any significant solar cycle variation in the intensity and spatial distribution of lightning activity on the global scale. The solar cycle-modulated local deformation of the Earth–ionosphere cavity by the ionization of energetic electron precipitation (EEP) has been suggested as a possible phenomenon that may account for the observed long-term modulation of SR intensity. Precipitating electrons in the energy range of 1–300 keV can affect the Earth–ionosphere cavity resonator in the altitude range of about 70–110 km and modify the SR intensities. However, until now there was no direct evidence documented in the literature supporting this suggestion. In this paper we present long-term SR intensity records from eight stations, each equipped with a pair of induction coil magnetometers: five high latitude (|lat| &gt; 60°), two mid-high latitude (50° &lt; |lat| &lt; 60°) and one low latitude (|lat| &lt; 30°). These long-term, ground-based SR intensity records are compared on the annual and interannual timescales with the fluxes of precipitating 30–300 keV medium energy electrons provided by the POES NOAA-15 satellite and on the daily timescale with electron precipitation events identified using a SuperDARN radar in Antarctica. The long-term variation of the Earth–ionosphere waveguide’s effective height, as inferred from its cutoff frequency, is independently analyzed based on spectra recorded by the DEMETER satellite. It is shown that to account for all our observations one needs to consider both the effect of solar X-rays and EEP which modify the quality factor of the cavity and deform it dominantly over low- and high latitudes, respectively. Our results suggest that SR measurements should be considered as an alternative tool for collecting information about and thus monitoring changes in the ionization state of the lower ionosphere associated with EEP.
Acupuncture Modulation Effect on Pain Processing Patterns in Patients With Migraine Without Aura
Authors: Tian Zilei , Guo Yaoguang , Yin Tao , Xiao Qingqing , Ha Guodong , Chen Jiyao , Wang Shuo , Lan Lei , Zeng Fang 
Published: August 2021

IntroductionIn this retrospective study, resting-state functional connectivity (FC) in patients with migraine was analyzed to identify potential pathological pain processing patterns and compared them to those in healthy controls (HCs). The FC patterns in patients between pre- and post-acupuncture sessions were also analyzed to determine how acupuncture affects neurological activity and pain perception during the migraine interictal period.MethodsIn total, 52 patients with migraine without aura (MwoA) and 60 HCs were recruited. Patients with migraine were given acupuncture treatment sessions for 4 weeks. As a primary observation, functional magnetic resonance images were obtained at the beginning and end of the sessions. HCs received no treatment and underwent one functional magnetic resonance imaging (fMRI) scan after enrollment. After the fMRI data were preprocessed, a region of interest (ROI)-to-ROI analysis was performed with predefined ROIs related to pain processing regions.ResultsThe first analysis showed significantly different FCs between patients with MwoA and HCs [false discovery rate correctedp-value (p-FDR) &lt; 0.05]. The FCs were found to be mainly between the cingulate gyrus (CG) and the insular gyrus, the CG and the inferior parietal lobule (IPL), the CG and the superior frontal gyrus, and the middle frontal gyrus and the IPL. The second analysis indicated that acupuncture treatment partly restored the different FCs found in the first analysis (p-FDR &lt; 0.05). Furthermore, subgroup analysis found different brain activity patterns in headache-intensity restored condition and headache-frequency restored condition. Lastly, the correlation analysis suggested a potential correlation between FCs and clinical symptoms (p&lt; 0.05).ConclusionThis study suggests that pain processing is abnormal in migraine, with significantly abnormal FCs in the frontal, parietal, and limbic regions. This finding could be a typical pathological feature of migraine. Acupuncture has been identified to relieve headache symptoms in two ways: it restores the pain processing function and regulates pain perception.
Use of a Biodegradable, Contrast-Filled Rectal Spacer Balloon in Intensity-Modulated Radiotherapy for Intermediate-Risk Prostate Cancer Patients: Dosimetric Gains in the BioPro-RCMI-1505 Study
Authors: Latorzeff Igor , Bruguière Eric , Bogart Emilie , Le Deley Marie-Cécile , Lartigau Eric , Marre Delphine , Pasquier David 
Published: August 2021

Background/purposeDose-escalated external beam radiotherapy (RT) is effective in the control of prostate cancer but is associated with a greater incidence of rectal adverse events. We assessed the dosimetric gain and safety profile associated with implantation of a new biodegradable rectal spacer balloon.Materials/methodsPatients scheduled for image-guided, intensity-modulated RT for intermediate-risk prostate cancer were prospectively included in the French multicenter BioPro-RCMI-1505 study (NCT02478112). We evaluated the dosimetric gain, implantation feasibility, adverse events (AEs), and prostate-cancer-specific quality of life associated with use of the balloon spacer.ResultsAfter a scheduled review of the initial recruitment target of 50 patients by the study’s independent data monitoring committee (IDMC), a total of 24 patients (including 22 with dosimetry data) were included by a single center between November 2016 and May 2018. The interventional radiologist who implanted the balloons considered that 86% of the procedures were easy. 20 of the 24 patients (83.3%) received IMRT and 4 (16.7%) received volumetric modulated arc therapy (78-80 Gy delivered in 39 fractions). The dosimetric gains associated with spacer implantation were highly significant (p&lt;0.001) for most variables. For the rectum, the median (range) relative gain ranged from 15.4% (-9.2−47.5) for D20cc to 91.4% (36.8−100.0) for V70 Gy (%). 15 patients (62%) experienced an acute grade 1 AE, 8 (33%) experienced a late grade 1 AE, 1 (4.2%) experienced an acute grade 2 AE, and 3 experienced a late grade 2 AE. No grade 3 AEs were reported. Quality of life was good at baseline (except for sexual activity) and did not markedly worsen during RT and up to 24 months afterwards.ConclusionThe use of a biodegradable rectal spacer balloon is safe, effective and associated with dosimetric gains in modern RT for intermediate-risk prostate cancer.
Survival Benefits of Simple Versus Extended Cholecystectomy and Lymphadenectomy for Patients With T2 Gallbladder Cancer: A Propensity-Matched Population-Based Study (2010 to 2015)
Authors: Zhang Wei , Huang Zhangkan , Wang Wen-er , Che Xu 
Published: August 2021

ObjectiveThis article aims to evaluate the survival benefits of simple cholecystectomy, extended cholecystectomy, as well as scope regional lymphadenectomy for T2 gallbladder cancer (GBC) patients.MethodsWe identified eligible patients from the Surveillance, Epidemiology, and End Results database. The confounding factors were controlled via propensity score matching. The log-rank test was utilized to compare overall survival. The multivariate Cox regression was then used to determine risk factors.ResultsOverall, data from 1,009 patients were obtained. The median overall survival (OS) of 915 patients that underwent simple cholecystectomy was 15 months; the median OS of 94 patients that underwent extended cholecystectomy was 17 months. There were no significant differences before and after propensity score matching (p = 0.542 and p = 0.258). The patients who received regional lymphadenectomy did show significant survival benefit, compared to those who did not receive regional lymphadenectomy. Furthermore, this benefit is observed in the N0 stage, but not observed in the N1 stage. In addition, the OS of patients who received lymphadenectomy for four or more regions was significantly better than those who received one to three regions lymphadenectomy. Age, the scope of regional lymphadenectomy, N stage, and tumor size were identified as prognostic factors.ConclusionsExtended cholecystectomy was not observed to significantly improve postoperative prognosis of patients with T2 GBC. However, there was a significant survival benefit shown for those with regional lymphadenectomy, particularly for patients with negative lymph nodes. Future studies on the control of potential confounding factors and longer follow-ups are still needed.
When Alterations in Social Cognition Meet Subjective Complaints in Autism Spectrum Disorder: Evaluation With the “ClaCoS” Battery
Authors: Morel-Kohlmeyer Shasha , Thillay Alix , Roux Sylvie , Amado Isabelle , Brenugat Lindsay , Carteau-Martin Isabelle , Danset-Alexandre Charlotte , Gaudelus Baptiste , Graux Jérôme , Peyroux Elodie , Prost Zelda , Krebs Marie-Odile , Franck Nicolas , Bonnet-Brilhault Frédérique , Houy-Durand Emmanuelle 
Published: August 2021

Background:Deficit in social communication is a core feature in Autism Spectrum Disorder but remains poorly assessed in classical clinical practice, especially in adult populations. This gap between needs and practice is partly due to a lack of standardized evaluation tools. The multicentric Research group in psychiatry GDR3557 (Institut de Psychiatrie) developed a new battery for social cognitive evaluation named “ClaCoS,” which allows testing the main components of social cognition: Emotion Recognition, Theory of Mind, Attributional Style, and Social Perception and Knowledge. It further provides an assessment of subjective complaints in social cognition.Methods:We compared the social cognition abilities of 45 adults with Autism Spectrum Disorder without intellectual disability and 45 neurotypically developed volunteers using the “ClaCoS” battery, in order to determine its relevance in the evaluation of social cognition impairments in autism. A correlational approach allowed us to test the links between subjective complaints and objectively measured impairments for the different components of social cognition.Results:As expected, the Autism Spectrum Disorder group showed deficits in all four components of social cognition. Moreover, they reported greater subjective complaints than controls regarding their social abilities, correlated to the neuropsychological assessments.Conclusion:The “ClaCoS” battery is an interesting tool allowing to assess social impairments in autism and to specify the altered components, for a better adjustment of tailored social cognition training programs. Our results further suggest that people with Autism Spectrum Disorder have a good social cognitive insight, i.e., awareness into social cognitive functioning, and may thus benefit from social cognitive training tools.
“More and More Fond of Reading”: Everything You Wanted to Know about Transgender Studies but Were Afraid to Ask Clara Reeve
Authors: Huthwaite Desmond 
Published: August 2021

Clara Reeve’s (1729–1807) Gothic novel The Old English Baron is a node for contemplating two discursive exclusions. The novel, due to its own ambiguous status as a gendered “body”, has proven a difficult text for discourse on the Female Gothic to recognise. Subjected to a temperamental dialectic of reclamation and disavowal, The Old English Baron can be made to speak to the (often) subordinate position of Transgender Studies within the field of Queer Studies, another relationship predicated on the partial exclusion of undesirable elements. I treat the unlikely transness of Reeve’s body of text as an invitation to attempt a trans reading of the bodies within the text. Parallel to this, I develop an attachment genealogy of Queer and Transgender Studies that reconsiders essentialism―the kind both practiced by Female Gothic studies and also central to the logic of Reeve’s plot―as a fantasy that helps us distinguish where a trans reading can depart from a queer one, suggesting that the latter is methodologically limited by its own bad feelings towards the former.
The Combination of a Biocontrol Agent Trichoderma asperellum SC012 and Hymexazol Reduces the Effective Fungicide Dose to Control Fusarium Wilt in Cowpea
Authors: Zhang Chongyuan , Wang Weiwei , Xue Ming , Liu Zhen , Zhang Qinman , Hou Jumei , Xing Mengyu , Wang Rui , Liu Tong 
Published: August 2021

The use of synthetic fungicide needs to be gradually reduced because of its adverse effect on human health and the environment. An integrated approach combining fungicides with biological control agents (BCAs) can be used to reduce the fungicide doses, thereby minimizing the risks associated with chemical fungicides. In this study, the combined application of a BCA Trichoderma and a fungicide hymexazol was used to manage the cowpea wilt disease caused by Fusarium oxysporum. The Trichoderma SC012 strain, which is resistant to hymexazol, was screened out and identified as T. asperellum. T. asperellum SC012 showed hyperparasitism to F. oxysporum and could penetrate and encircle the hyphae of pathogen on a medium amended or not with hymexazol. When combined with hymexazol, the population density in the rhizosphere soil of cowpea showed no significant difference compared with the treatment Trichoderma used alone. When the concentration of T. asperellum SC012 or hymexazol was halved, their combined application could control cowpea wilt disease more effectively than their individual use. The findings showed that the combination of Trichoderma and hymexazol could reduce the use of chemical fungicide, which is eco-friendly and may be an important part of integrated control of Fusarium wilt in cowpea.
Khazanah Tersembunyi yang Semakin Lenyap: Seni Ukiran Patung Kayu Suku Kaum Jah Hut
Authors: Abdullah Sani Nor Edzrine , Abd Arif Harleny 
Published: August 2021

Ukiran patung kayu merupakan satu simbol kekuatan dalam masyarakat suku kaum Jah Hut. Suku kaum Jah Hut menjadikan ukiran patung kayu ini sebagai bahan perantaraan bagi menjalankan upacara ritual dalam kehidupan mereka suatu ketika dahulu. Kajian ini dijalankan untuk mengetahui fungsi ukiran patung kayu dalam kehidupan masyarakat Orang Asli suku kaum Jah Hut di Kg Kol, Ulu Cheka Jerantut. Manakala, objektif kajian pula adalah untuk mengenal pasti sejauh mana penghasilan ukiran patung kayu dapat direalisasikan dalam kehidupan mereka sehingga ke hari ini. Pendekatan kualitatif melalui kajian kes telah digunakan bagi menerangkan secara deskriptif budaya masyarakat Orang Asli suku kaum Jah Hut. Temu bual tidak berstruktur, pemerhatian, analisis dokumen dan rakaman visual merupakan kaedah yang telah digunakan. Berdasarkan maklumat yang diperoleh semasa kerja di lapangan, dapatan kajian mendapati corak hidup suku kaum Jah Hut adalah berpegang kepada kepercayaan, adat dan warisan. Pada masa kini masyarakat Orang Asli telah mula mengecapi arus pemodenan dalam kehidupan mereka. Seiring dengan arus pemodenan, warisan tinggalan nenek moyang mereka seharusnya tidak dilupakan. Penulisan ini adalah bertujuan untuk berkongsi pengalaman dan pengetahuan pengkaji tentang khazanah yang semakin lenyap bagi seni ukiran patung kayu kaum Jah Hut
Disappearing Hidden Treasures: The Carving of Wooden Sculptures of the Jah Hut Tribe
Abstract: The wooden sculpture carving is a symbol of strength in the Jah Hut tribal society. The Jah Hut tribe used this wooden sculpture as an intermediate material to carry out ritual ceremonies in the past. This study was conducted to find out the function of wooden sculpture carving in the life of Orang Asli community of the Jah Hut tribe in Kg Kol, Ulu Cheka Jerantut. Meanwhile, the objective of the study is to identify how far the production of wooden sculptures can be realized in their lives to this day. A qualitative approach through case studies has been used to describe descriptively the culture of the Orang Asli community of the Jah Hut tribe. Unstructured interviews, observations, document analysis and visual recordings are the methods that have been used. Based on the information obtained during the work in the field, the findings of the study found that the lifestyle of the Jah Hut tribe is adhering to beliefs, customs and heritage. Nowadays, the Orang Asli community has begun to enjoy the current of modernization in their lives. Along with the currents of modernization, the legacy of their ancestors should not be forgotten. This writing aims to share the experience and knowledge of researchers about the disappearing treasures of the Jah Hut tribe wood sculpture art.
Keywords: Culture, Jah Hut, Beliefs, Wood Sculpture.
MODELING, ANALYSIS, AND COUNTERACTION MEASURES FOR IMPLEMENTATION SCENARIOS OF INFORMATION SECURITY THREATS ON MOBILE DEVICES
Authors: Сердечный Алексей Леонидович , Сторожев Глеб Валерьевич , Тарелкин Михаил Андреевич , Пахомова Анна Степановна 
Published: August 2021

В настоящей статье представлены результаты моделирования способов реализации компьютерных атак на мобильные устройства. Актуальность данной статьи обусловлена отсутствием наработок по формированию методического обеспечения, касающегося моделирования способов реализации компьютерных атак на мобильные устройства, учитывающего их специфику. Предложенные модели способов предназначены для формирования методического обеспечения расчета рисков и выявления оценки защищенности таких систем от актуальных сценариев реализации угроз безопасности информации, которое даёт возможность обоснованного выбора мер защиты. Построение моделей способов реализации компьютерных атак осуществлялось с использованием аппарата сетей Петри на основании сведений, содержащихся в базе данных MITRE ATT&CK. Разработанные модели взаимосвязаны по условиям и последствиям реализации основных технических приёмов, определённых в базе данных ATT&CK и актуальных для мобильных устройств (условия и последствия моделируются позициями сети Петри, а сами технические приёмы - переходами сети Петри). Также в статье затрагиваются вопросы автоматизации и совместной разработки подобных моделей. Проводится сравнительный анализ различных форм представления участков моделируемой сети Петри в контексте удобства процесса её разработки
This article presents the results of modeling methods for implementing computer attacks on mobile devices. The relevance of this article is due to the lack of developments in the formation of methodological support for modeling methods for implementing computer attacks on mobile devices, taking into account their specifics. These models are intended for the formation of methodological support for calculating risks and identifying the assessment of the security of such systems from current scenarios of information security threats, which makes it possible to make an informed choice of security measures. The construction of models of ways to implement computer attacks was carried out using the device of Petri nets based on the information contained in the MITRE ATT&CK database. These models are interconnected by the conditions and consequences of the implementation of the main techniques defined in the ATT&CK database and relevant for mobile devices (conditions and consequences are modeled by the positions of the Petri net, and the techniques themselves are modeled by the transitions of the Petri net). In article also addresses the issues of automation and joint development of such models. A comparative analysis of various forms of representation of the sections of the simulated Petri net in the context of the convenience of its development process is carried out.
SCIENTIFIC AND TECHNICAL RESULTS AND PROSPECTS OF THE "SECURE INTERNET" PROJECT IMPLEMENTATION
Authors: Остапенко Александр Григорьевич , Боков Илья Александрович , Остапенко Александр Алексеевич , Лантюхов Никита Михайлович , Мирошниченко Татьяна Юрьевна , Лихобабин Сергей Викторович , Трубицын Сергей Дмитриевич 
Published: August 2021

Рассматриваются цели, задачи и текущие результаты проекта «Безопасный Интернет». В этой связи формулируется мотивация создания проекта в условиях геополитической и цифровой трансформации глобального информационного общества. Кроме того, иллюстрируются основные результаты, полученные в ходе реализации проекта. При этом, авторами (с учетом футурологических прогнозов) дается краткий обзор вариантов развития политической и цифровой трансформации, а также - предлагаются горизонты развития предметной области настоящей работы и проекта «Безопасный Интернет». Фактически демонстрируются текущие достижения проекта и намечаются пути его совершенствования в современных условиях состояния и динамики глобального информационного пространства.
The goals, objectives and current results of the "Secure Internet"project are considered. In this regard, the motivation for the creation of the project in the context of the geopolitical and digital transformation of the global information society is formulated. In addition, the main results obtained during the implementation of the project are illustrated. At the same time, the authors (taking into account futurological forecasts) give a brief overview of the options for the development of political and digital transformation, as well as suggest the development horizons of the subject area of this work and the project "Safe Internet". In fact, it demonstrates the current achievements of the project and outlines ways to improve it in the current conditions of the state and dynamics of the global information space.