bluuebunny/crossref_metadata_2025_split huggingface dataset:
CP violating hW+W− coupling in the Standard Model and beyond
Authors: Huang Da , Morais António P. , Santos Rui 
Published: January 2021

Abstract
Inspired by the recent development in determining the property of the observed Higgs boson, we explore the CP-violating (CPV) $$ -{c}_{\mathrm{CPV}}{hW}^{+\mu \nu}{\tilde{W}}_{\mu \nu}^{-}/\upsilon $$
−

c
CPV

hW

+
μν

W
˜

μν
−

/
υ
coupling in the Standard Model (SM) and beyond, where W±μν and $$ {\tilde{W}}^{\pm \mu \nu} $$

W
˜

±
μν

denote the W-boson field strength and its dual. To begin with, we show that the leading-order SM contribution to this CPV vertex appears at two-loop level. By summing over the quark flavor indices in the two loop integrals analytically, we can estimate the order of the corresponding Wilson coefficient to be $$ {c}_{\mathrm{CPV}}^{\mathrm{SM}}\sim \mathcal{O}\left({10}^{-23}\right) $$

c
CPV
SM

∼
O

10

−
23

, which is obviously too small to be probed at the LHC and planned future colliders. Then we investigate this CPV hW+W− interaction in two Beyond the Standard Model benchmark models: the left-right model and the complex 2-Higgs doublet model (C2HDM). Unlike what happens for the SM, the dominant contributions in both models arise at the one-loop level, and the corresponding Wilson coefficient can be as large as of $$ \mathcal{O} $$
O
(10−9) in the former model and of $$ \mathcal{O} $$
O
(10−3) for the latter. In light of such a large CPV effect in the hW+W− coupling, we also give the formulae for the leading one-loop contribution to the related CPV hZZ effective operator in the complex 2-Higgs doublet model. The order of magnitude of the Wilson coefficients in the C2HDM may be within reach of the high-luminosity LHC or planned future colliders.
Predictions for axion couplings from ALP cogenesis
Authors: Co Raymond T. , Hall Lawrence J. , Harigaya Keisuke 
Published: January 2021

Abstract
Adding an axion-like particle (ALP) to the Standard Model, with a field velocity in the early universe, simultaneously explains the observed baryon and dark matter densities. This requires one or more couplings between the ALP and photons, nucleons, and/or electrons that are predicted as functions of the ALP mass. These predictions arise because the ratio of dark matter to baryon densities is independent of the ALP field velocity, allowing a correlation between the ALP mass, ma, and decay constant, fa. The predicted couplings are orders of magnitude larger than those for the QCD axion and for dark matter from the conventional ALP misalignment mechanism. As a result, this scheme, ALP cogenesis, is within reach of future experimental ALP searches from the lab and stellar objects, and for dark matter.
Geometric secret sharing in a model of Hawking radiation
Authors: Balasubramanian Vijay , Kar Arjun , Parrikar Onkar , Sárosi Gábor , Ugajin Tomonori 
Published: January 2021

Abstract
We consider a black hole in three dimensional AdS space entangled with an auxiliary radiation system. We model the microstates of the black hole in terms of a field theory living on an end of the world brane behind the horizon, and allow this field theory to itself have a holographic dual geometry. This geometry is also a black hole since entanglement of the microstates with the radiation leaves them in a mixed state. This “inception black hole” can be purified by entanglement through a wormhole with an auxiliary system which is naturally identified with the external radiation, giving a realization of the ER=EPR scenario. In this context, we propose an extension of the Ryu-Takayanagi (RT) formula, in which extremal surfaces computing entanglement entropy are allowed to pass through the brane into its dual geometry. This new rule reproduces the Page curve for evaporating black holes, consistently with the recently proposed “island formula”. We then separate the radiation system into pieces. Our extended RT rule shows that the entanglement wedge of the union of radiation subsystems covers the black hole interior at late times, but the union of entanglement wedges of the subsystems may not. This result points to a secret sharing scheme in Hawking radiation wherein reconstruction of certain regions in the interior is impossible with any subsystem of the radiation, but possible with all of it.
LAURENT POLYNOMIAL LANDAU–GINZBURG MODELS FOR COMINUSCULE HOMOGENEOUS SPACES
Authors: SPACEK PETER 
Published: January 2021

AbstractIn this article we construct Laurent polynomial Landau–Ginzburg models for cominuscule homogeneous spaces. These Laurent polynomial potentials are defined on a particular algebraic torus inside the Lie-theoretic mirror model constructed for arbitrary homogeneous spaces in [Rie08]. The Laurent polynomial takes a similar shape to the one given in [Giv96] for projective complete intersections, i.e., it is the sum of the toric coordinates plus a quantum term. We also give a general enumeration method for the summands in the quantum term of the potential in terms of the quiver introduced in [CMP08], associated to the Langlands dual homogeneous space. This enumeration method generalizes the use of Young diagrams for Grassmannians and Lagrangian Grassmannians and can be defined type-independently. The obtained Laurent polynomials coincide with the results obtained so far in [PRW16] and [PR13] for quadrics and Lagrangian Grassmannians. We also obtain new Laurent polynomial Landau–Ginzburg models for orthogonal Grassmannians, the Cayley plane and the Freudenthal variety.
Epidemiology of knife carrying among young British men
Authors: Coid Jeremy , Zhang Yingzhe , Zhang Yamin , Hu Junmei , Thomson Lindsay , Bebbington Paul , Bhui Kamaldeep 
Published: January 2021

Abstract
Purpose
Knife carrying has caused considerable public concern in the UK. But little is known of the epidemiology and characteristics of men who carry knives. We investigated associations with socioeconomic deprivation, area-level factors, and psychiatric morbidity.

Methods
Cross-sectional surveys of 5005 British men, 18–34 years, oversampling Black and Minority Ethnic (BME) men, lower social grades, and in London Borough of Hackney and Glasgow East. Participants completed questionnaires covering violent behaviour and psychiatric morbidity using standardised self-report instruments. Socioeconomic deprivation measured at small area level.

Results
Prevalence of knife carrying was 5.5% (4.8–6.9) and similar among white and BME subgroups. However, prevalence was twice the national rate in Glasgow East, and four times higher among Black men in Hackney, both areas with high levels of background violence and gang activity. Knife carrying was associated with multiple social problems, attitudes encouraging violence, and psychiatric morbidity, including antisocial personality disorder (AOR 9.94 95% CI 7.28–13.56), drug dependence (AOR 2.96 95% CI 1.90–4.66), and paranoid ideation (AOR 6.05 95% CI 4.47–8.19). There was no evidence of a linear relationship with socioeconomic deprivation.

Conclusion
Men who carry knives represent an important public health problem with high levels of health service use. It is not solely a criminal justice issue. Rates are increased in areas where street gangs are active. Contact with the criminal justice system provides opportunity for targeted violence prevention interventions involving engagement with integrated psychiatric, substance misuse, and criminal justice agencies.
Makulopathie bei Sichelzellerkrankung
Authors: Bachmeier Isabel , Blecha Christiane , Föll Jürgen , Wolff Daniel , Jägle Herbert 
Published: January 2021

Zusammenfassung
Hintergrund
Die Sichelzellerkrankung (SZE) ist eine hereditäre Hämoglobinopathie, die durch rezidivierende vasookklusive Episoden zur Mikrozirkulationsstörung verschiedener Organsysteme mit teils letalem Ausgang führt. Bei der okulären Manifestation der SZE ist am bekanntesten die periphere Sichelzellretinopathie (SZR). Unabhängig davon kann es bereits früh im Krankheitsverlauf zur Sichelzellmakulopathie (SZM) kommen.

Methoden
Review der internationalen und deutschsprachigen Literatur zur okulären Beteiligung bei SZE mit Fokus auf die SZR und SZM sowie Überblick über aktuelle systemische Therapieansätze bei SZE anlässlich der Vorstellung zweier Patienten mit HbSS-SZE.

Ergebnis und Schlussfolgerung
Im Gegensatz zur SZR ist die SZM mit temporaler Verdünnung der inneren Netzhautschichten erst in den letzten 5 Jahren mit der Einführung von SD-OCT und OCTA vermehrt in die Literatur eingegangen. Unabhängig vom Vorliegen einer SZR kann es immerhin bei etwa der Hälfte der Patienten bereits früh im Krankheitsverlauf zu einer SZM kommen. Das Krankheitsbild wird auch in Deutschland durch den Fortschritt der systemischen Therapiemöglichkeiten und aufgrund von Migration präsenter werden. Durch Wissen um diese Komplikation der SZE kann eine frühzeitige Diagnosestellung erfolgen und unnötige Diagnostik vermieden werden.
Steroid hormones and human choriogonadotropin influence the distribution of alpha6-integrin and desmoplakin 1 in gland-like endometrial epithelial spheroids
Authors: Buck V. U. , Kohlen M. T. , Sternberg A. K. , Rösing B. , Neulen J. , Leube R. E. , Classen-Linke I. 
Published: January 2021

AbstractIn human glandular endometrial epithelial cells, desmosomal and adherens junction proteins have been shown to extend from a subapically restricted lateral position to the entire lateral membrane during the implantation window of the menstrual cycle. Similarly, a menstrual cycle stage-dependent redistribution of the extracellular matrix adhesion protein α6-integrin has been reported. These changes are believed to be important for endometrial receptiveness and successful embryo implantation. To prove the hypothesis that steroid hormones and human choriogonadotropin can induce the redistribution of these adhesion molecules, we used the human endometrial cell line Ishikawa in a 3D culture system. Gland-like spheroids were grown in reconstituted basement membrane (Matrigel™). The lumen-bearing spheroids were treated for 2 or 4 days with ovarian steroids or human choriogonadotropin and then assessed by immunofluorescence microscopy. In addition, human endometrial biopsies were obtained from patients, who were in therapy for assisted reproductive technology, and were examined in parallel. Lateral redistribution of the desmosomal plaque protein desmoplakin 1 was observed in the spheroids treated either with progesterone, medroxyprogesterone acetate or human choriogonadotropin. Furthermore, the extracellular matrix adhesion protein α6-integrin showed an increased lateral membrane localization upon gestagen stimulation in the 3D culture system. The results of this study demonstrate that the 3D endometrial Ishikawa cell culture might be suited as an experimental model system to prove the effect of hormonal changes like those occurring during the window of implantation.
Relations between hemispheric asymmetries of grey matter and auditory processing of spoken syllables in 281 healthy adults
Authors: Guadalupe Tulio , Kong Xiang-Zhen , Akkermans Sophie E. A. , Fisher Simon E. , Francks Clyde 
Published: January 2021

AbstractMost people have a right-ear advantage for the perception of spoken syllables, consistent with left hemisphere dominance for speech processing. However, there is considerable variation, with some people showing left-ear advantage. The extent to which this variation is reflected in brain structure remains unclear. We tested for relations between hemispheric asymmetries of auditory processing and of grey matter in 281 adults, using dichotic listening and voxel-based morphometry. This was the largest study of this issue to date. Per-voxel asymmetry indexes were derived for each participant following registration of brain magnetic resonance images to a template that was symmetrized. The asymmetry index derived from dichotic listening was related to grey matter asymmetry in clusters of voxels corresponding to the amygdala and cerebellum lobule VI. There was also a smaller, non-significant cluster in the posterior superior temporal gyrus, a region of auditory cortex. These findings contribute to the mapping of asymmetrical structure–function links in the human brain and suggest that subcortical structures should be investigated in relation to hemispheric dominance for speech processing, in addition to auditory cortex.
The soluble glutathione transferase superfamily: role of Mu class in triclabendazole sulphoxide challenge in Fasciola hepatica
Authors: Stuart Rebekah B. , Zwaanswijk Suzanne , MacKintosh Neil D. , Witikornkul Boontarikaan , Brophy Peter M. , Morphew Russell M. 
Published: January 2021

AbstractFasciola hepatica (liver fluke), a significant threat to food security, causes global economic loss for the livestock industry and is re-emerging as a foodborne disease of humans. In the absence of vaccines, treatment control is by anthelmintics; with only triclabendazole (TCBZ) currently effective against all stages of F. hepatica in livestock and humans. There is widespread resistance to TCBZ and its detoxification by flukes might contribute to the mechanism. However, there is limited phase I capacity in adult parasitic helminths with the phase II detoxification system dominated by the soluble glutathione transferase (GST) superfamily. Previous proteomic studies have demonstrated that the levels of Mu class GST from pooled F. hepatica parasites respond under TCBZ-sulphoxide (TCBZ-SO) challenge during in vitro culture ex-host. We have extended this finding by exploiting a sub-proteomic lead strategy to measure the change in the total soluble GST profile (GST-ome) of individual TCBZ-susceptible F. hepatica on TCBZ-SO-exposure in vitro culture. TCBZ-SO exposure demonstrated differential abundance of FhGST-Mu29 and FhGST-Mu26 following affinity purification using both GSH and S-hexyl GSH affinity. Furthermore, a low or weak affinity matrix interacting Mu class GST (FhGST-Mu5) has been identified and recombinantly expressed and represents a new low-affinity Mu class GST. Low-affinity GST isoforms within the GST-ome was not restricted to FhGST-Mu5 with a second likely low-affinity sigma class GST (FhGST-S2) uncovered. This study represents the most complete Fasciola GST-ome generated to date and has supported the potential of subproteomic analyses on individual adult flukes.
Identification of CXCL11 as part of chemokine network controlling skeletal muscle development
Authors: Puchert Malte , Koch Christian , Zieger Konstanze , Engele Jürgen 
Published: January 2021

AbstractThe chemokine, CXCL12, and its receptors, CXCR4 and CXCR7, play pivotal roles during development and maintenance of limb muscles. CXCR7 additionally binds CXCL11, which uses CXCR3 as its prime receptor. Based on this cross-talk, we investigate whether CXCL11 would likewise affect development and/or function of skeletal muscles. Western blotting and immunolabelling demonstrated the developmentally restricted expression of CXCL11 in rat limb muscles, which was contrasted by the continuous expression of its receptors in proliferating and differentiating C2C12 cells as well as in late embryonic to adult rat limb muscle fibres. Consistent with a prime role in muscle formation, functional studies identified CXCL11 as a potent chemoattractant for undifferentiated C2C12 cells and further showed that CXCL11 does neither affect myoblast proliferation and differentiation nor metabolic/catabolic pathways in formed myotubes. The use of selective receptor antagonists unravelled complementary effects of CXCL11 and CXCL12 on C2C12 cell migration, which either require CXCR3/CXCR7 or CXCR4, respectively. Our findings provide new insights into the chemokine network controlling skeletal muscle development and function and, thus, might provide a base for future therapies of muscular diseases.
Roboter im Bergbau – wo liegt der Bedarf?
Authors: Sifferlinger Nikolaus A. 
Published: January 2021

ZusammenfassungDurch die rauen Umgebungsbedingungen untertage und die Gefahr von Steinfall oder sogar Gebirgsschlägen ist der Mensch im Bergbau immer einem Restrisiko ausgesetzt.Um wirklich automatische Bereiche im Bergbau ohne Personenzutritt betreiben zu können, wird es notwendig sein, Roboter für die Installation, Wartung und Betrieb von Anlagen verfügbar zu haben, die den Menschen vor Ort ersetzen können.Der Beitrag gibt eine kurze Übersicht über den Bedarf an Robotern im Bergbau, den derzeitigen Zustand und die Auswirkungen auf die Lehre und Forschung an der Montanuniversität Leoben.
Melanization as unfavorable factor in amelanotic melanoma cell biology
Authors: Skoniecka A. , Cichorek M. , Tyminska A. , Pelikant-Malecka I. , Dziewiatkowski J. 
Published: January 2021

AbstractThe biology of three amelanotic melanoma cell lines (Ab, B16F10, and A375) of different species origin was analyzed during in vitro induced melanization in these cells. Melanin production was induced by DMEM medium characterized by a high level of L-tyrosine (a basic amino acid for melanogenesis). The biodiversity of amelanotic melanoma cells was confirmed by their different responses to melanogenesis induction; Ab hamster melanomas underwent intensive melanization, mouse B16F10 darkened slightly, while human A375 cells did not show any change in melanin content. Highly melanized Ab cells entered a cell death pathway, while slight melanization did not influence cell biology in a significant way. The rapid and high melanization of Ab cells induced apoptosis documented by phosphatidylserine externalization, caspase activation, and mitochondrial energetic state decrease. Melanoma cell type, culture medium, and time of incubation should be taken into consideration during amelanotic melanoma cell culture in vitro. L-tyrosine, as a concentration-dependent factor presented in the culture media, could stimulate some amelanotic melanoma cell lines (Ab, B16F10) to melanin production. The presence of melanin should be considered in the examination of antimelanoma compounds in vitro, because induction of melanin may interfere or be helpful in the treatment of amelanotic melanoma.
Psychotherapie-Outcome-Studien bei Psychosen, Depressionen und Persönlichkeitsstörungen im Jugend- und jungen Erwachsenenalter
Authors: Steinmair Dagmar , Prevendar Tamara , Milic Branca , Hochgerner Marian , Löffler-Stastka Henriette 
Published: January 2021

ZusammenfassungBis zu 50 % aller Jugendlichen entwickeln psychische Symptome, ein Viertel wird psychisch krank. Die Hälfte der psychisch erkrankten Erwachsenen war bereits im Jugendalter von einer psychischen Störung betroffen. Die aufkommende Evidenz für den positiven Effekt früher psychotherapeutischer Interventionen macht Screeningmaßnahmen und begleitende Forschung notwendig.
Adolescents’ perceived barriers and facilitators to seeking and accessing professional help for anxiety and depressive disorders: a qualitative interview study
Authors: Radez Jerica , Reardon Tessa , Creswell Cathy , Orchard Faith , Waite Polly 
Published: January 2021

AbstractAnxiety and depressive disorders are the most common mental health disorders in adolescents, yet only a minority of young people with these disorders access professional help. This study aims to address this treatment gap by improving our understanding of barriers and facilitators to seeking/accessing professional help as perceived by adolescents with anxiety/depressive disorders identified in the community. Twenty-two adolescents, aged 11–17 years, who met diagnostic criteria for a current anxiety and/or depressive disorder were identified through school-based screening. In-depth qualitative interviews were conducted one-to-one with each adolescent and adolescents’ parents were interviewed separately for the purpose of data triangulation. Data were analysed using reflexive thematic analysis. We identified four themes capturing adolescent perceived barriers and facilitators to seeking/accessing professional help for anxiety and depressive disorders: (1) making sense of difficulties, (2) problem disclosure, (3) ambivalence to seeking help, and (4) the instrumental role of others. Barriers/facilitators identified within each theme reflect important developmental characteristics of adolescence, such as a growing need for autonomy and concerns around negative social evaluation. At the same time, the results highlight adolescents’ dependency on other people, mainly their parents and school staff, when it comes to successfully accessing professional help for their mental health difficulties. This study identifies a number of barriers/facilitators that influence help-seeking behaviour of adolescents with anxiety and/or depressive disorders. These factors need to be addressed when targeting treatment utilisation rates in this particular group of young people.
Effect of MRI acquisition acceleration via compressed sensing and parallel imaging on brain volumetry
Authors: Dieckmeyer Michael , Roy Abhijit Guha , Senapati Jyotirmay , Wachinger Christian , Grundl Lioba , Döpfert Jörg , Bertran Pere Ferrera , Lemke Andreas , Zimmer Claus , Kirschke Jan S. , Hedderich Dennis M. 
Published: January 2021

Abstract
Objectives
To investigate the effect of compressed SENSE (CS), an acceleration technique combining parallel imaging and compressed sensing, on potential bias and precision of brain volumetry and evaluate it in the context of normative brain volumetry.

Materials and methods
In total, 171 scans from scan-rescan experiments on three healthy subjects were analyzed. Each subject received 3D-T1-weighted brain MRI scans at increasing degrees of acceleration (CS-factor = 1/4/8/12/16/20/32). Single-scan acquisition times ranged from 00:41 min (CS-factor = 32) to 21:52 min (CS-factor = 1). Brain segmentation and volumetry was performed using two different software tools: md.brain, a proprietary software based on voxel-based morphometry, and FreeSurfer, an open-source software based on surface-based morphometry. Four sub-volumes were analyzed: brain parenchyma (BP), total gray matter, total white matter, and cerebrospinal fluid (CSF). Coefficient of variation (CoV) of the repeated measurements as a measure of intra-subject reliability was calculated. Intraclass correlation coefficient (ICC) with regard to increasing CS-factor was calculated as another measure of reliability. Noise-to-contrast ratio as a measure of image quality was calculated for each dataset to analyze the association between acceleration factor, noise and volumetric brain measurements.

Results
For all sub-volumes, there is a systematic bias proportional to the CS-factor which is dependent on the utilized software and subvolume. Measured volumes deviated significantly from the reference standard (CS-factor = 1), e.g. ranging from 1 to 13% for BP. The CS-induced systematic bias is driven by increased image noise. Except for CSF, reliability of brain volumetry remains high, demonstrated by low CoV (< 1% for CS-factor up to 20) and good to excellent ICC for CS-factor up to 12.

Conclusion
CS-acceleration has a systematic biasing effect on volumetric brain measurements.