bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical spectrum and prognosis of SLE-associated severe thrombopenia: A single-center review of 162 treatment-naïve patients
Authors: Liu Lijun , Liu Shengyun , Wang Cong , Li Wei , Liu Xiaojun , Sun Jinlei , Lu Jiameng , Zhang Yinli , Zhang Lei , He Yujie , Li Tianfang 
Published: April 2021

Abstract
Background

Severe thrombocytopenia (TP) is a common manifestation of systemic lupus erythematosus (SLE) that increases the risk of accruing damage and mortality. This study aimed to describe the demographic features, clinical characteristics, laboratory findings and outcomes of a large series of treatment-naïve SLE patients with severe TP and explore the factors influencing prognosis in patients with SLE-associated TP.
Methods

The study enrolled treatment-naïve SLE patients complicated with severe TP who were older than 14 years old and admitted to our hospital between November 2010 and November 2018. Demographic, clinical and laboratory data were collected retrospectively between October 2019 and February 2020.
Results

TP occurred in 31.83% of SLE patients, of whom 37.80% had severe TP. 162 treatment-naïve SLE patients complicated with severe TP were included in the analysis, including 17 males. The clinical and laboratory features are shown in Table 1–2. The treatment responses are displayed in Table 3–4, and the parallel program model is shown in Fig. 1. Multivariate analysis of the risk factors is shown in Table 5.
Conclusions

In patients with SLE-associated TP, male and older age predicted the lack of a response, serositis predicted the lack of a complete response, and anti-Sm antibodies predicted a response in week 1. Advanced age predicted the lack of a complete response at week 4, and anti-nRNP antibodies and anti-SSB antibodies predicted a complete response. Advanced age, myositis and anti-Ro antibodies predicted the lack of a response at week 24, and leukocytopenia predicted the lack of a complete response. Pulmonary arterial hypertension was predictive of serious infections. Myositis and leukopenia were predictive of mortality. Advanced age and mucocutaneous hemorrhage predicted the lack of a low-dose glucocorticoid complete response (LDG-CR), while anti-nRNP antibodies were predictive of LDG-CR.
Quantifying bubbling emission (ebullition) of methane from a rice paddy using high-time-resolution concentration data obtained during a closed-chamber measurement
Authors: KAJIURA Masako , TOKIDA Takeshi 
Published: April 2021

Abstract
Methane (CH4) produced in rice-paddy soil is transported to the atmosphere either via the rice plants or by bubbling events (ebullition); however, little is known about the frequency and intensity of bubbling CH4 emissions and the factors that affect them. We developed a method to quantify ebullition using high-time-resolution (~1 Hz) CH4 concentration data obtained by closed-chamber measurements. Field measurements were conducted in a Japanese rice paddy at different rice growth stages: panicle formation (PF), booting (BT), and heading (HD). A dataset of 132 chamber measurements was used to develop and evaluate the method. A scripting file written in R programing language was used to automatically determine CH4 emissions via the two pathways. Plant-mediated CH4 emission intensity was constant during chamber deployment and was reflected as a steady linear increase in chamber [CH4] with time or as a constant baseline in a flux time series. We found that the plant-mediated emission could be determined as the peak with the lowest flux intensity in the flux frequency distribution even if bubbling events occurred during the chamber deployment. The field measurement results in combination with established data processing protocols showed that at PF, ebullition contributed only 4% of the total emission, whereas it accounted for 32% and 60% of the total emission at BT and HD, respectively. In contrast, the plant-mediated flux variation among growth stages was smaller. Both ebullition and plant-mediated emissions correlated significantly with air temperature at HD, but the magnitude of the dependency was much higher for ebullition than for rice-mediated emission. These results demonstrate that ebullition occurs more frequently than has previously been thought, and the different transport pathways show varying degrees of dependency on plant phenological and environmental factors, thus underscoring the need to separately determine CH4 emissions via each transport pathway.
Assessment of factors affecting willingness to blood donation among Hawassa town Population Southern, Ethiopia,2020.
Authors: Girma Belete , Deneke Hiwot , Ahmed Yusuf 
Published: April 2021

Abstract
Background: Blood donation is a unique act to save the lives of people who face serious surgical and medical conditions. Since the request for blood supply is too high, there is a shortage of blood which causes significant morbidity and mortality. To increase blood supply and maintain adequate quantity of blood, regular and volunteer blood donation practice is needed. Ethiopia is one of the lowest annual donation rates which is 0.8/1000 population. This study assesses factors affecting willingness to donate blood among Hawassa town southern Population.Objectives: To assess the factors affecting willingness to blood donation among Hawassa town population Southern, Ethiopia.Methods: Community based cross-sectional study was conducted in Hawassa town in November 2020. A multi-stage sampling procedure was used to select study population. At Stage one, three Kebele are selected from total 32 Kebele, at stage two using systematical sampling method used to draw the total sample size, proportional to the population of each kebele and each study units are selected randomly from Each household. Data was collected using structured interviewer questionnaire. Data entered and analyzed using SPSS version 20.Result: A total of 633 participants were included in the final analysis (response rate = 100%). Among which 212(33.5%) was Female and 421 (66.5%) were Male. The mean age was 30.95 ±2.0 years. Among the study participants, 490(77.4) are willing to donate blood in the future and 125(22.9%) of them had blood donation practices in the past. The most prominent factors that affect willingness of participant for blood donation was, Unfit to donate, fear of needle prick and Not approached to donate (45.2%,38.5% and 11.7%) respectively. Majority of the respondents 382 (60.3%) reported that voluntary donor is the best source of safe blood. Desire to help other and age of study Participant age greater 25 years are significantly associated factor for increased willingness to blood donation (AOR 2.146 (0.028, 0.753) and (AOR = 1.8 (95% CI 1.1, 3.0) respectively.Conclusion: Only minor proportion of the participants donate blood in the past, but Majority of the participant was willing to donate blood in the future. The major factors that participant not willing to donate blood are Unfit to donate, fear of needle prick and Not approached to donate. There is a need to improve awareness on who and when a person able to donate a blood and organizing campaign to increase awareness on important of blood donation for those who are willing to donate blood in the future, to create a pool of eligible blood donors.
Análisis numérico del flujo sobrexpandido en la tobera cónica experimental ULA-2 fuera de diseño
Authors: Tolentino Masgo San Luis Baudilio , Mírez Tarrillo Jorge Luis 
Published: April 2021

En la Universidad de Los Andes, Venezuela, el GCAE ha diseñado y fabricado un grupo de toberas supersónicas con longitud de garganta, las cuales han sido empleadas en su fase experimental en motores de cohetes sonda de la serie ULA. En el presente trabajo el objetivo es analizar el comportamiento del campo de flujo sobrexpandido en la tobera cónica experimental ULA-2, que tiene un ángulo medio de la divergente de , considerado una tobera fuera de diseño. El campo de flujo se simuló en un dominio computacional 2D con el código Ansys-Fluent para dos casos de longitud de garganta; se empleó el modelo RANS en conjunto con el modelo de turbulencia de Menter, y para la viscosidad la ley de Sutherland. Los resultados del campo de número de Mach, presión y temperatura, para la sección de la garganta con mayor longitud presentaron fluctuaciones producto de las ondas de choque oblicuas, y para la menor longitud no se presentaron fluctuaciones. Se concluye que existe una influencia de la longitud de garganta en el desarrollo del flujo en esa sección; sin embargo, la longitud de garganta no influye de manera significativa en la velocidad del flujo a la salida de la tobera
Evaluación de las propiedades mecánicas de ladrillos elaborados con residuos de vidrio y plástico. Análisis de las emisiones de dióxido de carbono
Authors: Cardona Howard Faber Sneider , Rengifo Rojas Luis Alberto , Guarín Martínez Juan Felipe , Mazo Castro Daniel Guillermo , Arbeláez Pérez Oscar Felipe 
Published: April 2021

El uso de desechos no biodegradables como el vidrio y el plástico en la industria de la construcción ha recibido atención significativa para un medio ambiente más limpio. Este trabajo presenta un estudio de las propiedades mecánicas de ladrillos que contienen agregados, vidrio y pellets de tereftalato de polietileno. Los ladrillos se fundieron a 240 °C durante 3 horas y se enfriaron por convección natural. Los resultados mostraron que un aumento en el contenido de vidrio y agregados genera un incremento en la densidad, que es superior en las muestras con mayor contenido de agregados. La misma tendencia se observó en la resistencia a la compresión: la muestra con mayor contenido de agregados mostró una mejora del 243 % comparada con la referencia (preparada solo con plástico). Los resultados indicaron que las emisiones de dióxido de carbono disminuyeron alrededor del 30 % en las muestras preparadas, en comparación con los ladrillos tradicionales. Se espera que el uso de residuos de plástico y vidrio en la producción de ladrillos se convierta en una ruta para su valorización.
Investigating the effect of hydrogen peroxide as an electron acceptor in increasing the capability of slurry photocatalytic process in dye removal
Authors: Rahmati Roxana , Nayebi Behnam , Ayati Bita 
Published: April 2021

Abstract
The hydrogen peroxide role in photocatalytic degradation of an anionic azo dye, Acid Orange 7 (AO7), was investigated in a slurry reactor. Commercial ZnO nanoparticles with an average size between 10 to 30 nm were used as catalysts. Optimum conditions for different parameters, including dye concentration (10–100 mg/L), catalyst concentration (0.1–0.5 g/L), and pH (5–10), were determined first in the absence of H2O2. Changes in the COD were measured for the optimum condition. The impact of adding hydrogen peroxide at different concentrations to the system operating at optimum conditions was investigated. It was observed that 0.416 mM hydrogen peroxide increased the system's efficiency and decreased reaction time by 40 min. The reaction followed first-order kinetic. Hydrogen peroxide alone did not contribute to oxidizing the contaminant, and its positive impact was attributed to decreasing electron-hole recombination in the photocatalytic process. Not only can the hydrogen peroxide-assisted photocatalytic process decrease retention time in treatment units, but it can also result in more contaminant degradation. Therefore, it can reduce the treatment cost.
Strategy for the Enrichment of Protein Biomarkers from Diverse Bacterial Select Agents
Authors: Sabna Sasikumar , Kamboj Dev Vrat , Kumar Ravi Bhushan , Babele Prabhakar , Rajoria Sakshi , Gupta Mahendra Kumar , Alam Syed Imteyaz 
Published: April 2021

Background:
Some pathogenic bacteria can be potentially used for nefarious applications
in the event of bioterrorism or biowarfare. Accurate identification of biological agent from
clinical and diverse environmental matrices is of paramount importance for implementation of medical
countermeasures and biothreat mitigation.

Objective:
A novel methodology is reported here for the development of a novel enrichment strategy
for the generally conserved abundant bacterial proteins for an accurate downstream species identification
using tandem MS analysis in biothreat scenario.

Methods:
Conserved regions in the common bacterial protein markers were analyzed using bioinformatic
tools and stitched for a possible generic immuno-capture for an intended downstream
MS/MS analysis. Phylogenetic analysis of selected proteins was carried out and synthetic constructs
were generated for the expression of conserved stitched regions of 60 kDa chaperonin
GroEL. Hyper-immune serum was raised against recombinant synthetic GroEL protein.

Results:
The conserved regions of common bacterial proteins were stitched for a possible generic
immuno-capture and subsequent specific identification by tandem MS using variable regions of the
molecule. Phylogenetic analysis of selected proteins was carried out and synthetic constructs were
generated for the expression of conserved stitched regions of GroEL. In a proof-of-concept study,
hyper-immune serum raised against recombinant synthetic GroEL protein exhibited reactivity with
~60 KDa proteins from the cell lysates of three bacterial species tested.

Conclusion:
The envisaged methodology can lead to the development of a novel enrichment strategy
for the abundant bacterial proteins from complex environmental matrices for the downstream
species identification with increased sensitivity and substantially reduce the time-to-result.
Natural Products Targeting Cancer Stem Cells: A Revisit
Authors: Cui Jiahua , Qian Jiajun , Chow Larry Ming-Cheung , Jia Jinping 
Published: April 2021

Background:
The proposed central role of cancer stem cells (CSCs) in tumor
development has been extended to explain the diverse oncologic phenomena such as multidrug
resistance, metastasis and tumor recurrence in clinics. Due to the enhanced expression
of ATP-binding cassette transporters and anti-apoptotic factors, stagnation on G0
phase and the strong ability of self-renewal, the CSCs were highly resistant to clinical anticancer
drugs. Therefore, the discovery of new drug candidates that could effectively
eradicate cancer stem cells afforded promising outcomes in cancer therapy.

Objective:
Natural products and their synthetic analogues are a rich source of biologically
active compounds and several of them have already been recognized as potent CSCs
killers. We aim to provide a collection of recently identified natural products that suppressed
the survival of the small invasive CSC populations and combated the drug resistance
of these cells in chemotherapy.

Results:
These anti-CSCs natural products included flavonoids, stilbenes, quinones, terpenoids,
polyketide antibiotics, steroids and alkaloids. In the present review, we highlighted
the therapeutic potential of natural products and their derivatives against the proliferation
and drug resistance of CSCs, their working mechanisms and related structure-
activity relationships.

Conclusion:
Meanwhile, in this survey, several natural products with diverse cellular targets
such as the naphthoquinone shikonin and the stilbene resveratrol were characterized
as promising lead compounds for future development.
Anticancer Potential of Coumarin and its Derivatives
Authors: Bhattarai Narayan , Kumbhar Anupa A. , Pokharel Yuba Raj , Yadav Paras Nath 
Published: April 2021

:
Coumarins are found in higher plants like Rutaceae and Umbelliferae and essential oils of
cinnamon bark, cassia leaf, and lavender oil. Coumarin compounds show different biological properties,
viz antimicrobial, antibacterial, antifungal, antioxidant, antitumor, anti-HIV, antihypertension, anticoagulant,
anticancer, antiviral, anti-inflammatory, analgesics, antidiabetic, anti-depressive, and other bioactive
properties. Coumarin and its derivatives possess anticancer activity against different types of cancers
such as prostate, renal, breast, laryngeal, lung, colon, CNS, leukemia, malignant melanoma. In this review,
current developments of coumarin-based anticancer agents viz simple coumarin, furanocoumarin,
pyranocoumarin, pyrone-substituted coumarin, and their important derivatives have been discussed. The
coumarin-triazole, coumarin-chalcone, coumarin-thiosemicarbazone derivatives, and coumarin-metal
complexes have been found more potent than coumarin. Hence, further study and structural improvement
on coumarin and its derivatives may lead to the design and development of more potent anticancer
agents.
Effect of Yoga on Oxidative Stress in Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis
Authors: Maheshkumar K. , Venugopal V. , Geethanjali S. , Poonguzhali S. , Padmavathi R. , Mahadevan S. , Silambanan S. 
Published: April 2021

Background:
Diabetes mellitus has a significant impact on public health. Oxidative
stress plays a major role in the pathophysiology of type 2 diabetes mellitus (T2DM), leading to various
complications of T2DM. Yoga is being widely used in the management of T2DM. The primary
objective of this systematic review and meta-analysis is to understand the effects of yoga on oxidative
stress parameters among adult patients diagnosed with T2DM.

Materials and methods:
Electronic databases such as PubMed, Scopus, Cochrane Library and Science
Direct from start of the study till March 2020 were searched to obtain eligible studies. Study
designs of all nature were included (except case studies and reviews). The primary outcome was
malondialdehyde (MDA) and secondary outcomes included fasting plasma glucose, HbA1C and superoxide
dismutase (SOD) levels.

Results:
A total of four trials with a total of 440 patients met the inclusion criteria. The results of
meta-analysis indicated that yoga significantly reduced MDA (SMD: -1.4 ; 95% CI -2.66 to -0.13;
P = 0.03; I2 = 97%), fasting plasma glucose levels (SMD: –1.87: 95% CI -3.83 to -0.09; P =
0.06;I2= 99%), and HbA1c (SMD: -1.92; 95% CI - 3.03 to -0.81; P = 0.0007; I2 = 92%) in patients
with T2DM. No such effect was found for SOD (SMD: -1.01; 95% CI -4.41 to 2.38; P = 0.56; I2=
99%).

Conclusion:
The available evidence suggests that yoga reduces MDA, fasting plasma glucose and
HbA1C, and thus would be beneficial in the management of T2DM as a complementary therapy.
However, considering the limited number of studies and its heterogeneity, further robust studies
are necessary to strengthen our findings and investigate the long-term benefits of yoga.
Recent Developments in Biopolymeric Nanoparticles for Drug Delivery
Systems: An Overview
Authors: Barik Soumya R. , Mohapatra Ranjan K. , Mohapatra Pranab K. , Mahal Ahmed , El-Ajaily Marei M. 
Published: April 2021

:
Nanotechnology has gained momentum in recent years in the field of drug delivery, including
nanomedicine and nano-delivery systems. Several applications such as biological agents,
chemotherapeutic agents and immunotherapeutic agents are used for the treatment of a number of
diseases. This review compiles an updated summary on recent developments in this emerging field
of nanomedicines and nanotechnology-based drug delivery systems. The study of nanostructured
drug delivery systems helps to understand the efficient transport and controlled release of drugs to
the diseased tissues of living organisms. This has stimulated the authors to highlight recent advances
in smart nanocarriers composed of biopolymeric nanoparticles such as liposomes, dendrimers, and
hydrogels. This review also highlights some critical issues in the design of nanocarrier systems for
biomedical applications.
The Association of Unfairness with Mental and Physical Health in a Multiethnic Sample of Adults: Cross-sectional Study
Authors: Resnicow Ken , Patel Minal , Green Molly , Smith Alyssa , Bacon Elizabeth , Goodell Stefanie , Kilby Dylan , Tariq Madiha , Alhawli Asraa , Syed Nadia , Griggs Jennifer , Stiffler Matthew 
Published: April 2021

Background
Two psychosocial constructs that have shown consistent associations with negative health outcomes are discrimination and perceived unfairness.

Objective
The current analyses report the effects of discrimination and unfairness on medical, psychological, and behavioral outcomes from a recent cross-sectional survey conducted in a multiethnic sample of adults in Michigan.

Methods
A cross-section survey was collected using multiple approaches: community settings, telephone-listed sample, and online panel. Unfairness was assessed with a single-item previously used in the Whitehall study, and everyday discrimination was assessed with the Williams 9-item scale. Outcomes included mental health symptoms, past-month cigarette use, past-month alcohol use, past-month marijuana use, lifetime pain medication use, and self-reported medical history.

Results
A total of 2238 usable surveys were collected. In bivariate analyses, higher unfairness values were significantly associated with lower educational attainment, lower age, lower household income, and being unmarried. The highest unfairness values were observed for African American and multiracial respondents followed by Middle Eastern or North African participants. Unfairness was significantly related to worse mental health functioning, net adjustment for sociodemographic variables, and everyday discrimination. Unfairness was also related to self-reported history of depression and high blood pressure although, after including everyday discrimination in the model, only the association with depression remained significant. Unfairness was significantly related to 30-day marijuana use, 30-day cigarette use, and lifetime opiate use.

Conclusions
Our findings of a generally harmful effect of perceived unfairness on health are consistent with prior studies. Perceived unfairness may be one of the psychological pathways through which discrimination negatively impacts health. Future studies examining the relationships we observed using longitudinal data and including more objective measures of behavior and health status are needed to confirm and extend our findings.
DAMPAK PENGEMBANGAN EKOWISATA TERHADAP KESEJAHTERAAN MASYARAKAT DI KABUPATEN BENGKAYANG : Studi Kasus Kawasan Ekowisata Riam Pangar
Authors: Pynanjung Pramushinta Arum 
Published: April 2021

Konsep kepariwisataan dunia mengalami pergeseran ke arah model wisata alam akibat tingkat kejenuhan wisatawan􀀎untuk mengunjungi objek-objek wisata buatan. Hal ini merupakan peluang bagi Indonesia untuk memanfaatkan pesona alamnya. Salah satu ekowisata yang terkena, yaitu kawasan wisata di daerah Kabupaten Gunung Kidul-Yogyakarta yang sering dikunjungi wisatawan, namun tidak demikian dengan ekowisata di Kalimantan Barat. Ekowisata di Kalimantan Barat yang berjumlah 333 destinasi tidak sebanding dengan jumlah kunjungan wisatawan seperti halnya di objek wisata lainnya. Salah satu daerah di Kalimantan Barat yang berpotensi adalah Kabupaten Bengkayang yang memiliki 51 objek wisata. Penelitian ini bertujuan untuk menjelaskan peran pengembangan kawasan ekowisata yang mempunyai potensi di kemudian hari terhadap peningkatan kesejahteraan masyarakat sekitar. Sedangkan pendekatan yang digunakan adalah mix method, dengan metode studi kasus. Teknik pengumpulan data melalui data primer (wawancara / kuisioner) dan data sekunder (studi literatur). Berdasarkan penelitian sebelumnnya (Reny & Pramushinta, 2016) bahwa kawasan Riam Pangar cukup berpotensi, namun perlu di perbaiki baik dari segi daya tarik, sarana dan prasarana, mutu dan pelayanan, pengelolaan dan perawatan sampai regulasi kebijakan yang mengatur ekowisata di daerah tersebut. Pengembangan ekowisata di kawasan Riam Pangar dapat menimbulkan dampak positif maupun dampak negatif bagi pihak-pihak terkait. Dampak yang di timbulkan dapat mengurangi angka pengangguran, peningkatan pendapatan, peningkatan inflasi dan nilai lahan sampai mempercepat proses pembangunan di daerah kawasan tersebut. Hasil penelitian ini diharapkan dapat menjadi informasi dan rekomendasi kepada Pemerintah Kabupaten Bengkayang dalam menentukan alternatif kebijakan dan strategi yang tepat untuk pengembangan pengelolaan wisata alam di Kabupaten Bengkayang terutama daerah kawasan Air Terjun Riam Pangar.