bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness and return on investment of school-based health promotion programmes for chronic disease prevention
Authors: Ekwaru John P , Ohinmaa Arto , Dabravolskaj Julia , Maximova Katerina , Veugelers Paul J 
Published: July 2021

Abstract

Background
While school-based health prevention programmes are effective in addressing unhealthy diet and physical inactivity, little is known about their economic implications. We conducted an economic evaluation of the programmes that were previously identified as feasible, acceptable, and sustainable in the Canadian context.

Methods
This study builds on a meta-analysis of the effectiveness of feasible, acceptable, and sustainable school-based health promotion programmes. A micro-simulation model incorporated intervention effects on multiple risk factors to estimate incremental cost-effectiveness and return on investment (ROI) of comprehensive school health (CSH), multicomponent, and physical education (PE) curriculum modification programmes. Cost-effectiveness was expressed as the programme costs below which the programme would be cost-effective at a CA$50 000 threshold level.

Results
The estimated costs below which interventions were cost-effective per quality-adjusted life year gained were CA$682, CA$444, and CA$416 per student for CSH, multicomponent, and PE curriculum modification programmes, respectively. CSH programmes remained cost-effective per year of chronic disease prevented for costs of up to CA$3384 per student, compared to CA$1911 and CA$1987 for multicomponent and PE curriculum modification interventions, respectively. If the interventions were implemented at total discounted intervention costs of CA$100 per student, ROI through the avoidance of direct healthcare costs related to the treatment and management of chronic diseases would be 824% for CSH, 465% for multicomponent interventions, and 484% for PE curriculum modification interventions.

Conclusions
Whereas each examined intervention types showed favourable economic benefits, CSH programmes appeared to be the most cost-effective and to have the highest ROI.
The interactions of bacteriophage Ace and Shiga toxin-producingEscherichia coliduring biocontrol
Authors: Pinto Graça , Minnich Scott A , Hovde Carolyn J , Oliveira Hugo , Smidt Hauke , Almeida Carina , Azeredo Joana 
Published: July 2021

ABSTRACTStrictly lytic phages are considered powerful tools for biocontrol of foodborne pathogens. Safety issues needed to be addressed for the biocontrol of Shiga toxin-producing Escherichia coli (STEC) include: lysogenic conversion, Shiga toxin production through phage induction, and emergence/proliferation of bacteriophage insensitive mutants (BIMs). To address these issues, two new lytic phages, vB_EcoS_Ace (Ace) and vB_EcoM_Shy (Shy), were isolated and characterized for life cycle, genome sequence and annotation, pH stability and efficacy at controlling STEC growth. Ace was efficient in controlling host planktonic cells and did not stimulate the production of the Stx prophage or Shiga toxin. A single dose of phage did not lead to the selection of BIMs. However, when reintroduced, BIMs were detected after 24 h of incubation. The gain of resistance was associated with lower virulence, as a subset of BIMs failed to agglutinate with O157-specific antibody and were more sensitive to human serum complement. BIM's biofilm formation capacity and susceptibility to disinfectants was equal to that of the wild-type strain. Overall, this work demonstrated that phage Ace is a safe biocontrol agent against STEC contamination and that the burden of BIM emergence did not represent a greater risk in environmental persistence and human pathogenicity.
A candidate chromosome inversion in Arctic charr (Salvelinus alpinus) identified by population genetic analysis techniques
Authors: Hale Matthew C , Campbell Matthew A , McKinney Garrett J 
Published: July 2021

Abstract
The “genomics era” has allowed questions to be asked about genome organization and genome architecture of non-model species at a rate not previously seen. Analyses of these genome-wide datasets have documented many examples of novel structural variants (SVs) such as chromosomal inversions, copy number variants, and chromosomal translocations, many of which have been linked to adaptation. The salmonids are a taxonomic group with abundant genome-wide datasets due to their importance in aquaculture and fisheries. However, the number of documented SVs in salmonids is surprisingly low and is most likely due to removing loci in high linkage disequilibrium when analyzing structure and gene flow. Here we re-analyze RAD-seq data from several populations of Arctic charr (Salvelinus alpinus) and document a novel ∼1.2 MB SV at the distal end of LG12. This variant contains 15 protein-coding genes connected to a wide-range of functions including cell adhesion and signal transduction. Interestingly, we studied the frequency of this polymorphism in four disjointed populations of charr—one each from Nunavut, Newfoundland, Eastern Russia, and Scotland—and found evidence of the variant only in Nunavut, Canada, suggesting the polymorphism is novel and recently evolved.
Role-Based Framing of Older Adults Linked to Decreased Ageism Over 210 Years: Evidence From a 600-Million-Word Historical Corpus
Authors: Ng Reuben , Indran Nicole 
Published: July 2021

Abstract

Background and Objectives
Older adults are exhibiting greater diversity in their aging trajectories. This has led to movements by the World Health Organization and AARP to reframe aging. We compare role-based framing and age-based framing of older adults over 210 years—a time span beyond the reach of traditional methods—and elucidate their respective sentiments and narratives.

Research Design and Methods
We combined the Corpus of Historical American English with the Corpus of Contemporary American English to create a 600-million-word data set—the largest historical corpus of American English with over 150,000 texts collected from newspapers, magazines, fiction, and nonfiction. We compiled the top descriptors of age-based terms (e.g., senior citizen) and role-based terms (e.g., grandparent) and rated them for stereotypic valence (negative to positive) over 21 decades.

Results
Age-based framing evidenced a significantly higher increase in negativity (15%) compared to role-based framing (4%). We found a significant interaction effect between framing (age-based vs. role-based) and stereotypic content across 2 centuries (1800s and 1900s). The percentage of positive topics associated with role-based framing increased from 71% in the 1800s to 89% in the 1900s, with narratives of affection and wisdom becoming more prevalent. Conversely, the percentage of positive topics for age-based framing decreased from 82% to 38% over time, with narratives of burden, illness, and death growing more prevalent.

Discussion and Implications
We argue for a more role-centric approach when framing aging such that age ceases to be the chief determinant in how older adults are viewed in society.
Contested Childhood: Assessing the Age of Young Refugees in the Aftermath of the Second World War
Authors: Burgard Antoine 
Published: July 2021

Abstract
In the immediate aftermath of the Second World War, identity documents and proofs of age were often lost or unavailable, bodies and behaviours had been marked by years of malnourishment and persecution, young people had learned to misrepresent their age for the sake of survival, and administrations routinely doubted age claims. The war had profoundly disrupted the system for knowing age that had become central to Western European regimes of recognition and rights such as citizenship, movement, and welfare. Using the resettlement of young Holocaust survivors to Canada after the war as its core case study, this article examines how state administrations, international organizations, and non-governmental organizations competed and struggled to determine age and consequently who should be considered as a child, and how young people themselves were affected by and navigated these struggles. It foregrounds the necessity to further historicize how power structures increasingly used childhood as a category and chronological age as a supposedly objective criterion to grant some lives more legitimacy than others.
Leptinergic Regulation of Vertebrate Communication Signals
Authors: Nourbakhsh-Rey Mehrnoush , Markham Michael R 
Published: July 2021

Abstract
Animal communication signals are regulated by multiple hormonal axes that ensure appropriate signal targeting, timing, and information content. The regulatory roles of steroid hormones and many peptide hormones are well understood and documented across a wide range of vertebrate taxa. Two recent studies have reported a novel function for leptin, a peptide hormone central to energy balance regulation: regulating communication signals of weakly electric fish and singing mice. With only limited evidence available at this time, a key question is just how widespread leptinergic regulation of communication signals is within and across taxa. A second important question is what features of communication signals are subject to leptinergic regulation. Here, we consider the functional significance of leptinergic regulation of animal communication signals in the context of both direct and indirect signal metabolic costs. Direct costs arise from metabolic investment in signal production, while indirect costs arise from the predation and social conflict consequences of the signal's information content. We propose a preliminary conceptual framework for predicting which species will exhibit leptinergic regulation of their communication signals and which signal features leptin will regulate. This framework suggests a number of directly testable predictions within and across taxa. Accounting for additional factors such as life history and the potential co-regulation of communication signals by leptin and glucocorticoids will likely require modification or elaboration of this model.
Novel FtsZ inhibitor with potent activity against Staphylococcus aureus
Authors: Kumar Manoj , Mathur Tarun , Barman Tarani Kanta , Chaira Tridib , Kumar Ram , Joshi Vattan , Pandya Manisha , Sharma Lalima , Fujii Kunihiko , Bandgar Mahadev , Jadhav Balasaheb , Bambal Ramesh , Upadhyay Dilip , Masuda Nobuhisa , Verma Ashwani Kumar , Bhatnagar Pradip Kumar 
Published: July 2021

Abstract

Objectives
FtsZ is an essential bacterial protein and an unexplored target for the development of antibacterial drugs. The development of a novel inhibitor targeting FtsZ offers a potential opportunity to combat drug resistance. DS01750413, a new derivative of PC190723, is a novel FtsZ inhibitor with improved in vitro and in vivo activity. The objective of this study was to investigate the efficacy of DS01750413 against Staphylococcus spp., including MRSA, in in vitro and in vivo models.

Methods
In vitro activities of DS01750413 and standard-of-care antibiotics were evaluated against clinical isolates of Gram-positive pathogens. The in vivo efficacy was evaluated in a murine systemic infection model caused by MRSA.

Results
DS01750413 showed potent in vitro activity against MRSA clinical isolates with MIC ranges of 0.5–1 mg/L and also demonstrated concentration-dependent bactericidal killing. In the murine bacteraemia infection model of MRSA, treatment with DS01750413 resulted in prolonged survival of animals compared with placebo-treated animals and exhibited a significant reduction in the bacterial load in liver, spleen, lungs and kidneys.

Conclusions
DS01750413 showed encouraging in vitro and in vivo activity against MRSA. As a novel chemical class, DS01750413 has the potential to become clinically viable antibiotics to address the drug resistance problem by its unique novel targeting mechanism of action.
Comparison of Breath- and Blood-Alcohol Concentrations in a Controlled Drinking Study
Authors: Skaggs Lindsey , Heizler Amy , Kalscheur Diane , Miles Amy , Barkholtz Heather M 
Published: July 2021

AbstractIn this work, 114 volunteers were dosed with 80-proof liquor to produce peak blood-alcohol concentration (BAC) or breath-alcohol concentration (BrAC) of 0.040–0.080 g/100 mL blood or g/210 L breath. This was followed by a 30 minute deprivation period before simultaneous blood and breath samples were collected and the alcohol concentration quantified. BAC was determined by gas chromatography with flame ionization detection and BrAC by a dual-sensor Intox EC/IR II instrument. Paired Student t-tests showed that differences between paired blood- and breath-alcohol results differed significantly. Results from these two measurement methods are highly correlated and, on average, measured BAC was 11.3% greater than BrAC. There were 10 instances of BrAC being greater than the corresponding BAC, and the average difference between these two values was 0.0059 g/100 mL. Agreement plots of coupled BAC and BrAC revealed a mean bias of 0.00754 g/100 mL and 95% limits of agreement (LOA) at −0.00705 and 0.0221 g/100 mL. Once BrAC values were truncated to the hundredths place as required by Wisconsin state statute, only three participants had greater BrAC than corresponding BAC, with an average difference between these values of 0.008 g/100 mL. Agreement plots with truncated BrAC values gave a mean bias of 0.0120 g/100 mL and 95% LOA at −0.00344 and 0.0275 g/100 mL. Data showed that typically, blood samples had greater alcohol concentrations than corresponding breath values. Differences were exacerbated by Wisconsin’s statutory requirement that reported breath alcohol measurements be truncated to the hundredths place, whereas blood has no corresponding mandate.
Design process of patient-specific osteosynthesis plates using topology optimization
Authors: Park Si-Myung , Park Soyeon , Park Jieun , Choi Minwook , Kim Laehyun , Noh Gunwoo 
Published: July 2021

Abstract
To reduce complications related to the osteosynthesis plating system, the use of a patient-specific plate design was proposed. However, the issue of associated complications is still critical. Because existing patient-specific plate designs have mainly relied on parametric studies, a design method is needed that considers the complex factors influencing the performance of the reconstruction and that can be generalized for various patients. The goal of this study was to propose a design process that can strengthen the advantages of a customized plate to reduce patient discomfort and ensure the stability of surgery. We applied topology optimization to design a plate for a case of mandibular condyle fracture. The optimization problem was set to maximize the plate stiffness and minimize its volume. The performance of the designed plate was evaluated using finite element simulations, which approximated the various mastication states. Plate performance was then compared with the performance of two conventional plating systems: bent plates and computerized numerical control-machined plates. The conventional plate models used a pair of mini-plates, and the bent plate was modeled by conducting bending simulation. Each finite element model was appraised via masticatory simulations under static molar-jaw-closing conditions. Differences in stress concentration were noted between the model with bent plates and the model with computerized numerical control-machined plates. The most severe stress concentration occurred in the bent plate, which was affected by the residual stress from the bending process. In comparison with the two conventional plates, the newly designed plate exhibited significantly improved biomechanical stability in terms of stress and stiffness and had approximately twice the endurance capability against fractured bone separation. The newly designed plate was designed to have a balance between volume and plate stiffness, and it showed superior stability over the conventional plates. The proposed plate design process using topology optimization is an effective method not only because it enhances the advantages of the patient-specific plate but also because it can be applied in various reconstruction cases.
Auctioning Class Action Representation
Authors: Klement Alon , Neeman Zvika , Ofir Moran 
Published: July 2021

Abstract
Class actions feature severe agency problems, resulting from the divergence of interests between class members and the class attorney. This article proposes a novel mechanism for selecting the class attorney and aligning her interests with those of the represented class. The mechanism applies a combined percentage and hourly litigation fee structure, suggested by Polinsky, Mitchell A., and Daniel L. Rubinfeld. 2003. “Aligning the Interests of Lawyers and Clients,” 5 Am Law Econ Rev 165, in which lawyers earn a percentage of the class’ common fund, and bear the same percentage over their time investment. To maximize the expected payoff for the class, we supplement this fee structure with a preliminary two stages auction, in which the role of the lawyer is tendered using competitive bidding. We prove that the proposed auction approximates the highest possible net payoff for the class as the number of lawyers who compete for the right to represent the class increases. The percentage taken by the lawyer would be the lowest possible, and the winning lawyer would be the one who produces the highest expected net payoff for the class. We then extend the model to cases where the attorney files the class action is compensated for her pre-filing investment, and to settlements (JEL K41, K22)
COVID-19, Telehealth, and Pediatric Integrated Primary Care: Disparities in Service Use
Authors: Chakawa Ayanda , Belzer Leslee Throckmorton , Perez-Crawford Trista , Yeh Hung-Wen 
Published: July 2021

Abstract

Objective
The coronavirus disease 2019 pandemic (COVID-19) may increase pediatric mental health needs due to its social, economic, and public health threats, especially among Black, Indigenous, and People of Color and those served within disadvantaged communities. COVID-19 protocols have resulted in increased provision of telehealth in integrated primary care (IPC) but little is known about pediatric telehealth IPC utilization during the pandemic for diverse and traditionally underserved groups.

Methods
A comparative study was conducted to explore variability between in-person (pre-COVID-19; n = 106) and telehealth (mid-COVID-19; n = 120) IPC consultation utilization among children 1–19 years old served through a large, inner-city primary care clinic. Logistic regression modeling was used to examine the association between service delivery modality (i.e., in-person vs. telehealth) and attendance, referral concerns, and several sociodemographic variables.

Results
Service delivery modality and attendance, referral concerns, and race/ethnicity were significantly associated. The odds of non-attendance were greater for children scheduled for telehealth, the odds of children with internalizing problems being scheduled for telehealth were greater than those with externalizing problems, and the odds of Black children being scheduled for telehealth were less compared to White children.

Conclusion
Though telehealth has helped provide IPC continuity during COVID-19, findings from this study show troubling preliminary data regarding reduced attendance, increased internalizing concerns, and disparities in scheduling for Black patients. Specific actions to monitor and address these early but alarming indications of telehealth and Covid-19 related behavioral health disparities are discussed.
Idiopathic pleuroparenchymal fibroelastosis: first case report in Lebanon
Authors: Dbouk Samer , Bazzi Nagham , Mansour Sally , Masry Aly , Mansour Bassam 
Published: July 2021

Abstract
Idiopathic pleuroparenchymal fibroelastosis (IPPFE) was initially described by Amitani et al. in Japan. It is characterized by visceral pleural fibrosis and adjacent lung parenchymalfibroelastosis with striking upper lobe predominance. Because of its rarity and the lack of clear diagnostic criteria, the prevalence of the disease is still unclear. We report the first case of IPPFE in Lebanon and the second one in the Arab World. A 37-year-old Iraqi man was admitted to the hospital with progressive dyspnea on exertion occurring since 2 years and associated with dry cough. Histo-pathologic results reported a prominent interstitial fibrosis mainly in upper parts, and no granulomatous tissue was detected. Therefore, the diagnosis of IPPFE was made. The IPPFE is a distinct entity that requires meticulous clinico-pathological correlation for an adequate diagnosis and a close follow-up as this entity can progress into more advanced stages.
Detecting optical transients using artificial neural networks and reference images from different surveys
Authors: Wardęga Katarzyna , Zadrożny Adam , Beroiz Martin , Camuccio Richard , Díaz Mario C 
Published: July 2021

ABSTRACT
We present a technique to detect optical transients based on an artificial neural networks method. We describe the architecture of two networks capable of comparing images of the same part of the sky taken by different telescopes. One image corresponds to the epoch in which a potential transient could exist; the other is a reference image of an earlier epoch. We use data obtained by the Dr. Cristina V. Torres Memorial Astronomical Observatory and archival reference images from the Sloan Digital Sky Survey. We trained a convolutional neural network and a dense layer network on simulated source samples and then tested the trained networks on samples created from real image data. Autonomous detection methods replace the standard process of detecting transients, which is normally achieved by source extraction of a difference image followed by human inspection of the detected candidates. Replacing the human inspection component with an entirely autonomous method would allow for a rapid and automatic follow-up of interesting targets of opportunity. The toy-model pipeline that we present here is not yet able to replace human inspection, but it might provide useful hints to identify potential candidates. The method will be further expanded and tested on telescopes participating in the Transient Optical Robotic Observatory of the South Collaboration.