bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meteorological Pursuit in University of Gujrat, Pakistan (Part 2)
Authors: Maalik Umeed 
Published: June 2021

Abstract
Meteorological observation activity continued for 3 months in University of Gujrat small scale observatory. The cell phone message send to headquarter is uploaded there to the official website of Meteorological Department. This internet updating of weather is also a part of our discussion to check how important working of our station, other Regional stations and the World over. It is importance in various fields of Science, Technology, Hydrology, Aviation, Agriculture, and Defense for saving, wellbeing, and development of mankind and life on the Planet Earth. Chapter three and four are included in this part 2 of this Meteorological pursuit.
Particle orbiting motion in a confined microvortex
Authors: Shen Feng , Li Zong-He , Ai Ming-Zhu , Xue Sen , Xu Min , Liu Zhao-Miao 
Published: June 2021

Abstract
Particle motion in viscous fluids is a common and fascinating phenomenon. The hydrodynamics of a trapped finite-size particle recirculating along a stable orbit within a microvortex is still puzzling. Herein we report experimental observations of the orbiting motion of a finite-size particle in a vortex confined in a microcavity. The orbiting particle keeps crossing the streamlines with acute changes in velocity along the orbit, which can be divided into three stages: acceleration, swerving, and following. By examining the relationship between particle orbit and vortex streamlines, we uncover a particle slingshot effect and slip motion. Particle motion and vortex structure in three dimensions are also studied, revealing many new fascinating particle motion phenomena. The results provide new insights into the physics of particle motion in vortices.
Supported Online Self-Management Versus Care as Usual for Symptoms of Fatigue, Pain and Urgency/incontinence in Adults With Inflammatory Bowel Disease (IBD-BOOST): Study Protocol for a Randomized Controlled Trial.
Authors: Norton Christine , Syred Jonathan , Kerry Sally , Artom Micol , Sweeney Louise , Hart Ailsa , Czuber-Dochan Wladyslawa , Taylor Stephanie JC , Mihaylova Borislava , Roukas Chris , Aziz Qasim , Miller Laura , Pollok Richard , Saxena Sonia , Terry Helen , Stagg Imogen , Zenasni Zohra , Dibley Lesley , Moss-Morris Rona 
Published: June 2021

Abstract
BackgroundDespite being in clinical remission, many people with Inflammatory Bowel Disease (IBD) live with fatigue, chronic abdominal pain and bowel urgency or incontinence that limit their quality of life. We aim to test the effectiveness of an online self-management programme (BOOST), developed using cognitive behavioural principles and a theoretically informed logic model, and delivered with facilitator support. Primary research questionIn people with IBD who report symptoms of fatigue, pain or urgency and express a desire for intervention, does a facilitator-supported tailored (to patient needs) online self-management programme for fatigue, pain and faecal urgency/incontinence improve IBD-related quality of life (measured using the UK-IBDQ) and global rating of symptom relief (0-10 scale) compared with care as usual?MethodsA pragmatic two-arm, parallel group Randomised Controlled Trial (RCT), of a 12-session facilitator-supported online cognitive-behavioural self-management programme versus care as usual to manage symptoms of fatigue, pain, and faecal urgency/incontinence in IBD. Patients will be recruited through a previous large-scale survey of unselected people with inflammatory bowel disease. The UK Inflammatory Bowel Disease Questionnaire and global rating of symptom relief at 6 months are the co-primary outcomes, with multiple secondary outcomes measured also at 6 and 12 months post randomisation to assess maintenance. The RCT has an embedded pilot study, health economics evaluation and process evaluation. We will randomise 680 patients, 340 in each group. Demographic characteristics and outcome measures will be presented for both study groups at baseline. The UK-IBDQ and global rating of symptom relief at 6 and 12 months post randomisation will be compared between the study groups. DiscussionThe BOOST online self-management programme for people with IBD-related symptoms of fatigue, pain and urgency has been designed to be easily scalable and implemented. If it is shown to improve patients’ quality of life, this trial will enable clinicians and patients to make informed management decisions. This is the first trial, to our knowledge, focused on multiple symptoms prioritised by both people with IBD and health professionals. Trial registration﻿registered at ISRCTN, ID: ISRCTN71618461. Registered 09/09/2019. Available at: http://www.isrctn.com/ISRCTN71618461Protocol version 3: 28.04.2020
Decreasing water resources in Southeastern U.S. as observed by the GRACE satellites
Authors: Engström Johanna , Praskievicz Sarah , Bearden Bennett , Moradkhani Hamid 
Published: June 2021

AbstractChanging water quantities and location can be estimated using the Gravity Recovery and Climate Experiment (GRACE) satellites. By measuring differences in the Earth's gravity, the satellites provide monthly data on regional changes in the Earth's mass resulting from the movement of water. Studying the Southeast U.S., using the full record of the original GRACE satellites (2002–2016), a significant trend of declining water quantities appears in west-central Alabama, extending into eastern Mississippi. These findings confirm earlier research which indicates declining streamflow levels but develops this research further by estimating the amount lost as 11.6 km3. Considering the different terrestrial water storages by analyzing data from the National Climate Assessment – Land Data Assimilation System Noah 3.3 Version 2 (NCA-LDAS) indicates that the majority of this loss can be attributed to groundwater losses, a finding that is further confirmed by well records throughout the region.
Identification of Novel Drug Candidates for the Inhibition of Catalytic Cleavage Activity of Coronavirus 3CL-like Protease Enzyme
Authors: Gurung Arun Bahadur , Al-Anazi Khalid Mashay , Ali Mohammad Ajmal , Lee Joongku , Farah Mohammad Abul 
Published: June 2021

Background:
There has been tremendous pressure on healthcare facilities globally due to the
recent emergence of novel coronavirus infection known as COVID-19 and its rapid spread across the
continents. The lack of effective therapeutics for the management of the pandemic calls for the discovery
of new drugs and vaccines.

Objective:
In the present study, a chemical library was screened for molecules against three coronavirus
3CL-like protease enzymes (SARS-CoV-2 3CLpro, SARS-CoV 3CLpro and MERS-CoV 3CLpro), which
are a key player in the viral replication cycle.

Methods:
Extensive computational methods such as virtual screening and molecular docking were employed
in this study.

Results:
Two lead molecules, ZINC08825480 (4-bromo-N'-(E)-[1-phenyl-3-(pyridin-3-yl)-1H-pyrazol-
4-yl]methylidenebenzene-1-sulfonohydrazide) and ZINC72009942 (N-[[2-[[(3S)-3-methyl-1-piperidyl]
methyl]phenyl]methyl]-6-oxo-1-(p-tolyl)-4,5-dihydro-1,2,4-triazine-3-carboxamide), were identified
with better affinity with the three target enzymes as compared to the approved antiviral drugs. Both the
lead molecules possessed favorable drug-like properties, fit well into the active site pocket close to His-
Cys dyad and showed a good number of hydrogen bonds with the backbone as well as side chains of key
amino acid residues.

Conclusion:
Thus, the present study offers two novel chemical entities against coronavirus infections
which can be validated through various biological assays.
Utility of Certain 2-Furanone Derivatives for Synthesis of Different Heterocyclic Compounds and Testing their Anti-Cancer Activity
Authors: El-Hameed Rania Helmy Abd , El-Shanbaky Hend Medhat , Mohamed Mosaad Sayed 
Published: June 2021

Background:2-Furanones have attracted great attention due to their biological activities. They also have the ability to be converted to several biologically active heterocyclic and nonheterocyclic compounds, especially as anti-cancer agents.Objectives:This research aims to share in the development process of novel cytotoxic agents by synthesizing certain 2-furanone derivatives and using them as starting materials for the preparation of novel heterocyclic and non-heterocyclic compounds, then testing the synthesized derivatives for their anti-cancer activities.Methods:All the newly synthesized compounds were fully characterized by elemental analysis, IR, Mass, and 1H-NMR spectroscopy. 18 synthesized compounds were selected by National Cancer Institute (NCI) for testing against 60 cell lines, and the active compound was tested as MAPK14 and VEGFR2-inhibitor using Staurosporine as standard.Results:Compound 3a showed the higher activity against several cell lines; Leukemia (SR), Non- Small Cell Lung Cancer (NCI-H460), colon cancer (HCT-116), ovarian cancer (OVCAR-4), renal cancer (786-0, ACHN and UO-31) and, finally breast cancer (T-47D). It also has better inhibition activity against MAPK14 than the used reference.Conclusion:Compound 3a has promising anti-cancer activities compared to the used standards and may need further modification and investigations.
Efficient Synthesis and Biological Evaluation of 6-Trifluoroethoxy
Functionalized Pteridine Derivatives as EGFR Inhibitors
Authors: Lin Jin , Zhang Zemin , Lin Xiongqiang , Chen Zhendong , Luc Tian , Zha Daijun , Wang Jian , Xu Xiuzhi , Li Zhulai 
Published: June 2021

Background:
Pteridine-based scaffolds have been widely prevalent in pharmaceuticals,
such as kinase inhibitors targeting EGFR, FLT3 and PI3K/mTOR which are attractive targets for the
anticancer therapy.

Objective:
This work aimed at designing and synthesizing 6-2,2,2-trifluoroethoxy functionalized
pteridine-based derivatives for investigation of their anti-cancer activities as EGFR inhibitor.

Method:
Pteridine-based derivatives were synthesized in 6 steps involving amination, bromination,
cyclization, alkoxylation, chlorination and coupling reactions. Cellular anti-proliferative activities
and inhibition activities on EGFR signaling of these pteridine derivatives in vitro were determined by
the MTT assay and western blot analysis, respectively. Molecular docking simulation studies were
carried out by the crystallographic structure of the erlotinib/EGFR kinase domain [Protein Data Bank
(PDB) code: 1M17].

Results:
The compound 7m, with IC50 values of 27.40 μM on A549 cell line, exhibited comparable
anti-proliferative activity relative to the positive control. Besides, western blots showed its obvious
down-regulation of p-EGFR and p-ERK expression at 0.8 μM. The molecular docking model displayed
a hydrogen bond between Met-769 amide nitrogen and N-1 in pteridine motif of 7m which
lied at the ATP binding site of EGFR kinase domain.

Conclusion:
The inhibition of 7m on cellular growth was comparable to that of the positive control.
The inhibitory activities of 7m on EGFR phosphorylation and ERK phosphorylation in A549 cell line
were relatively superior to that of the positive control. Both results suggested that the antiproliferative
activity of 7m against A549 cell line was caused by inhibition of EGFR signaling pathway,
providing a new perspective for the modification of pteridine-based derivatives as EGFR inhibitor.
Ferulic Acid Dose Effect on Pharmacokinetics of Glimepiride and its Metabolite
Hydroxy Glimepiride in Rats
Authors: Xu Hui , Lin Yuxian , Sun Faxin , Liu Jinlai , Weng Qinghua , Jin Lijun , Chen Linguo , Huang Yiwei 
Published: June 2021

Background:
To mitigate diabetes and its complications in cardiovascular diseases,
the antidiabetic agent Glimepiride (GLM) is usually administered with Ferulic Acid (FA) concomitantly
in clinical settings. However, both drugs are prone to be metabolized partly by
CYP2C9; thus, they have the potential drug-drug interaction affecting safety and efficacy.

Objective:
This study aimed to evaluate the Pharmacokinetic (PK) effects of ferulic acid on
glimepiride and its metabolite hydroxy glimepiride (OH-GLM) in plasma by using the HPLCMS/
MS method.

Methods:
Healthy male Sprague Dawley (SD) rats were randomly divided into three groups and
received intragastric administration of 0.5% sodium Carboxymethyl Cellulose (CMC), low-dose
of FA (20 mg•kg-1 ), and high-dose of FA (40 mg•kg-1) for 8 days, respectively. Rats were given
0.5% sodium CMC or FA on the last day and then uniformly given 1.0 mg•kg-1 glimepiride by
gavage. Blood samples were obtained from retro-orbital plexus at the time points of 0.167, 0.5, 1,
2, 3, 4, 6, 8, 10, 12, and 24 h after administration. Plasma samples were analyzed for GLM and its
metabolite OH-GLM on an HPLC-MS/MS system.

Results:
No statistically significant difference was found in the effect of low-dose of FA on the
pharmacokinetics of GLM. However, high-dose of FA significantly decreased Cmax of GLM by
30.05% and CLz/F of OH-GLM by 47.45% and increased Tmax and t1/2z of GLM by 95.87% and
140.00%, respectively.

Conclusion:
Low-dose of FA did not alter GLM metabolism, while high-dose treatment of FA
apparently caused pharmacokinetics interaction with GLM in rats.
Correlation between social support and the achievement of the development of self-concept to deaf children 7 – 12 years
Authors: Nurmalasari Siti , Susanto Tantut , Nur Kholid Rosyidi Muhammad 
Published: June 2021

Children with deaf have a disability in language and communication because they cannot hear and understand their environment, so that is not uncommon for people around them to assume that children with deaf cannot live in the social environment. This matter shows the community to deaf children where it can affect children's self-concept with the deaf. This research aims to analyze the correlations between social support and self-concept in children with the deaf. A cross-sectional study was used to examine 51 children with deaf 7 – 12 years selected with a convenience sampling method. The questionnaire consisted of identity data used to measure participant characteristics. Social Support Questionnaire for children (SSQC) was used to measure social support and the Self-Description Questionnaire to measure self-concept. The Chi-Square test is used to answer the objectives of this study. From 51 respondents, 44 (86.3%) deaf children received good social support, with the most social support obtained from 36 friends (70.6%) and siblings 36 (70.6%). Of the five components of social support, only social support from friends and siblings most resulted in low-deaf children's self-concept. There was a relationship between social support and the self-concept of deaf children (Z = 1.833; p-value = 0.034). Support from various sources is needed for deaf children to develop self-concept in their social life. Therefore, the child's social environment needs to provide adequate social support for developing an excellent deaf child's self-concept.
Improving pregnancy care during the COVID-19 pandemic for pregnant women as vulnerable groups through assistance at the primary health care facility
Authors: Jauhar Muhamad , Lestari Kurniati Puji 
Published: June 2021

Since it was found in December 2019, the novel Coronavirus Disease 2019 (COVID-19) has spread from Wuhan, China, to many other countries. A rapid increase of newly found cases was observed, and finally, in March 2020, the World Health Organization declared that Coronavirus Disease 2019 (COVID-19) is a global pandemic. As one of the vulnerable groups, pregnant women need to avoid COVID-19 transmission and maintain pregnancy health during the pandemic. This study aimed to improve pregnant women's self-management during the COVID-19 pandemic in the working area of the Padangsari Primary Health Care Services, Semarang City. The research method used an experimental design with a pre-posttest without a control group. A Smartphone application, namely "SEHARI," was used to share the module and video about pregnancy health guidelines; furthermore, various activities of this study included online classes for pregnant women via a WhatsApp group, pregnancy care behavior surveys, and evaluations. The offline activity was done in 1 meeting for 90-120 minutes, while online activities were done as needed. This study's target population was 22 pregnant women in Puskesmas Padangsari Semarang City's working area selected by purposive sampling. A questionnaire was used that measures mother's behavior while engaging in pregnancy care and pregnancy examination screening. The validity and reliability tests showed that the instrument was valid and reliable to improve self-management of pregnant women during the COVID-19 pandemic in the working area. Bivariate data analysis of the independent variable's effect on the dependent variables used paired and independent t-tests to measure the self-management of pregnant women. The results showed that 50% of pregnant women fulfilled nutritional needs well, 59.1% of pregnant women did tetanus immunization, and 59.1% did pregnancy examinations and visits. Despite being a vulnerable group, pregnant women must continue their antenatal care during the pandemic with a strict health protocol. Specially designed online classes and Smartphone application can be used as media to deliver the essential health meassages so that pregnant women can still monitor their pregnancy health and have a way to bridge the existing programs in primary health care.
H63D Syndrome: data and facts
Authors: Diamandis Dr. Carolina , Adams Jacob S 
Published: June 2021

Ever since I co-founded the International H63D Research Consortium, I
have always considered it my duty to pass on the most important
knowledge about H63D syndrome to my colleagues in academia, research and
applied medicine.
Before I leave the consortium for a new career step, there are still
some data to be published, which my current colleagues will certainly
work on in more detail at a later stage. After all, knowledge can save
lives and prevent suffering. I will publish these data in the following,
because they speak for themselves.
Evaluation of horizontal condylar angle in malocclusions with mandibular lateral displacement using cone-beam computed tomography
Authors: Velásquez Roberto L. , Coro Jorge C. , Bustillo José M. , Sato Sadao 
Published: June 2021

ABSTRACT

Objectives
To evaluate the horizontal condylar angle (HCA) in mandibular lateral displacement (MLD).

Materials and Methods
HCA in MLD malocclusions were examined using cone-beam computed tomography data in subjects with MLD and control subjects.

Results
HCA in joints of control patients and contralateral side joints of MLD patients were not significantly different. The mean HCA on the shifted side was larger than on the contralateral side (P &lt; .001) in the different HCA groups. HCA was significantly larger on the shifted side than on the contralateral side in skeletal Class I, Class II, and Class III groups (P &lt; .001).

Conclusions
(1) There was no statistically significant difference between HCA in control patients and on the contralateral side in MLD patients. (2) HCA was significantly larger on the shifted side than on the contralateral side. (3) HCA on the shifted side and the contralateral side in MLD Class I, Class II, and Class III are significantly different.
Photoplethysmograph Portable Menggunakan Raspberry Pi
Authors: Bahri Saeful , Purwono Purwono 
Published: June 2021

Metode non-invasive untuk memonitor fungsi jantung yang sederhana adalah Photoplethysmography. Pada tulisan ini diuraikan Photoplethysmography dengan dua sumber cahaya (reflektif dan transmitter), satu fotosensor dengan dua kali pengkondisi sinyal (double BPF). Informasi sinyal detak jantung dimodulasikan pada frekuensi audible yang dihasilkan oleh osilator (IC555 timer) kemudian dikonversi menjadi data digital oleh USB sound card (sebagai ADC). Pemrosesan sinyal dilakukan menggunakan Raspberry Pi dan sofware JavaFX. Bentuk gelombang PPG, pulse, meanRR, sdRR, rMSSD, pNN50 dapat ditampilkan pada layar LCD 5 inch. Gelombang PPG morfologinya sama dengan gelombang ABP, dengan akuisi sinyal yang tepat, PPG menawarkan hal baru untuk manajemen penanganan PAD pada penderita diabetes militus, gagal ginjal dan usia lanjut. Dengan alat ini, detak jantung dapat dihitung dengan presentase kesalahan 0.098%. Pada display dapat ditampilan grafik gelombang yang menyerupai dengan bentuk gelombang masukan dan menjadi masa depan untuk pengganti ABP. Perbandingan pengukuran detak jantung antara alat dengan pulse oximetry menunjukan deviasi antara 0.1 - 0.4. A simple non-invasive method for monitoring cardiac function is Photoplethysmography. This paper describes Photoplethysmography with two light sources (reflective and transmitter), one photosensor with two signal conditioners (double BPF). The heart rate signal information is modulated at an audible frequency generated by the oscillator (IC555 timer) then converted into digital data by the USB sound card (as an ADC). Signal processing is performed using Raspberry Pi and JavaFX software. PPG, pulse, meanRR, sdRR, rMSSD, pNN50 waveforms can be displayed on the 5 inch LCD screen. The PPG wave is morphologically the same as the ABP wave, with precise signal acquisition, PPG offers a novelty for the management of PAD in people with diabetes mellitus, kidney failure and the elderly. With this tool, the heart rate can be calculated with an error percentage of 0.098%. On the display can be displayed a wave graph that resembles the input waveform and is a future for ABP replacement. Comparison of heart rate measurements between the device and pulse oximetry shows a deviation between 0.1 - 0.4.
Brama łez. Filmowe topografie Ellis Island
Authors: Kita Barbara 
Published: June 2021

Georges Perec traktuje Wyspę Imigrantów nad brzegami rzeki Hudson jako nie-miejsce, miejsce
którego nie ma. Jest to przestrzeń konotująca wiele różnych znaczeń, odwołująca się do
pamięci, tożsamości, nadziei i zarazem rozpaczy milionów ludzi, którzy przez nią przeszli, by
znaleźć się w wymarzonym świecie. Doświadczenia pasażerów statków, a potem rzuconych
na nieznany ląd imigrantów z całego świata co jakiś czas stają się tematem filmów, których
akcja częściowo w ciągu całej ich pielgrzymki rozgrywa się na Wyspie Ostryg. Tekst stanowi
próbę uporządkowania specyficznej topografii wyspy i skonfrontowania jej z obrazami filmowymi.
Z jednej strony wyspa to przestrzeń różnorodności ludzi, języków i kultur, z drugiej
zaś tworzy lokalność wynikającą z rozmiaru i położenia wyspy względem stałego lądu (Manhattanu) oraz buduje tymczasową swoistą lokalność grup ludzi pochodzących z różnych zakątków świata. Odniesienie do filmu Pereca i Bobera Opowieści z Ellis Island konstruuje rodzaj ramy o charakterze teoretycznym dla zaproponowanych rozważań na temat topografii wyspy, uzupełnia je film Ellis JR oraz pełnometrażowe filmy fabularne (Ojciec Chrzestny II Francisa Forda Coppoli, Brooklyn Johna Crowleya i inne).