bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyper Suprime-Cam Legacy Archive
Authors: Tanaka Masayuki , Ikeda Hiroyuki , Murata Kazumi , Takita Satoshi , Mineo Sogo , Koike Michitaro , Okura Yuki , Harasawa Sumiko 
Published: April 2021

AbstractWe present the launch of the Hyper Suprime-Cam Legacy Archive (HSCLA), a public archive of processed, science-ready data from the Hyper Suprime-Cam (HSC). HSC is an optical wide-field imager installed at the prime focus of the Subaru Telescope and has been in operation since 2014. While ∼1/3 of the total observing time of HSC has been used for the Subaru Strategic Program (SSP), the remainder of the time is used for Principal Investigator (PI)-based programs. We have processed the data from these PI-based programs and make the processed, high-quality data available to the community through HSCLA. The current version of HSCLA includes data taken in the first year of science operation, 2014. We provide both individual and coadd images as well as photometric catalogs. The photometric catalog from the coadd is loaded to the database, which offers a fast access to the large catalog. There are other online tools such as an image browser and an image cutout tool and they will be useful for science analyses. The coadd images reach 24–27th magnitudes at 5σ for point sources and cover approximately 580 square degrees in at least one filter with 150 million objects in total. We perform extensive quality assurance tests and verify that the photometric and astrometric quality of the data is good enough for most scientific explorations. However, the data are not without problems and users are referred to the list of known issues before exploiting the data for science. All the data and documentations can be found at the data release site, 〈https://hscla.mtk.nao.ac.jp/〉.
EnhFFL: A database of enhancer mediated feed-forward loops for human and mouse
Authors: Kang Ran , Tan Zhengtang , Lang Mei , Jin Linqi , Zhang Yin , Zhang Yiming , Guo Tailin , Guo Zhiyun 
Published: April 2021

AbstractFeed-forward loops (FFLs) are thought to be one of the most common and important classes of transcriptional network motifs involved in various diseases. Enhancers are cis-regulatory elements that positively regulate protein-coding genes or microRNAs (miRNAs) by recruiting DNA-binding transcription factors (TFs). However, a comprehensive resource to identify, store, and analyze the FFLs of typical enhancer and super-enhancer FFLs is not currently available. Here, we present EnhFFL, an online database to provide a data resource for users to browse and search typical enhancer and super-enhancer FFLs. The current database covers 46 280/7000 TF-enhancer-miRNA FFLs, 9997/236 enhancer-miRNA-gene FFLs, 3 561 164/3 193 182 TF-enhancer-gene FFLs, and 1259/235 TF-enhancer feed-back loops (FBLs) across 91 tissues/cell lines of human and mouse, respectively. Users can browse loops by selecting species, types of tissue/cell line, and types of FFLs. EnhFFL supports searching elements including name/ID, genomic location, and the conservation of miRNA target genes. We also developed tools for users to screen customized FFLs using the threshold of q value as well as the confidence score of miRNA target genes. Disease and functional enrichment analysis showed that master miRNAs that are widely engaged in FFLs including TF-enhancer-miRNAs and enhancer-miRNA-genes are significantly involved in tumorigenesis. Database URL:http://lcbb.swjtu.edu.cn/EnhFFL/.
The role of ‘Alay Kapwa Spirituality’ amid COVID-19 pandemic
Authors: Rosales Renniel Jayson Jacinto , Agena Kristel Eunice Geroleo 
Published: April 2021

Abstract
The importance of spiritual nourishment has become the hope of the people in dealing with the COVID-19 pandemic. This spiritual side of the people must be in tandem with the social responsibility for those in need. Dealing with both spiritual and social responsibilities points out the ‘Alay Kapwa Spirituality’. Thus, in both spiritual and social aspects, this paper highlights that practicing ‘Alay Kapwa Spirituality’ in the time of the Corona Virus Disease (COVID-19) pandemic is highly useful response in satisfying one’s spiritual thirst and social responsibility.
Plasticity in Prefrontal Cortex Induced by Coordinated Synaptic Transmission Arising from Reuniens/Rhomboid Nuclei and Hippocampus
Authors: Banks Paul J , Warburton E Clea , Bashir Zafar I 
Published: April 2021

Abstract
The nucleus reuniens and rhomboid nuclei of the thalamus (ReRh) are reciprocally connected to a range of higher order cortices including hippocampus (HPC) and medial prefrontal cortex (mPFC). The physiological function of ReRh is well predicted by requirement for interactions between mPFC and HPC, including associative recognition memory, spatial navigation, and working memory. Although anatomical and electrophysiological evidence suggests ReRh makes excitatory synapses in mPFC there is little data on the physiological properties of these projections, or whether ReRh and HPC target overlapping cell populations and, if so, how they interact. We demonstrate in ex vivo mPFC slices that ReRh and HPC afferent inputs converge onto more than two-thirds of layer 5 pyramidal neurons, show that ReRh, but not HPC, undergoes marked short-term plasticity during theta frequency transmission, and that HPC, but not ReRh, afferents are subject to neuromodulation by acetylcholine acting via muscarinic receptor M2. Finally, we demonstrate that pairing HPC followed by ReRh (but not pairing ReRh followed by HPC) at theta frequency induces associative, NMDA receptor dependent synaptic plasticity in both inputs to mPFC. These data provide vital physiological phenotypes of the synapses of this circuit and provide a novel mechanism for HPC–ReRh–mPFC encoding.
High-Quality Complete Genome Resource of Plant-Pathogenic Bacterium Dickeya solani IPO 2019, Isolated from Hyacinthus orientalis
Authors: Czajkowski Robert , Rabalski Lukasz , Bartnik Przemysław , Jafra Sylwia 
Published: April 2021

Dickeya solani is an emerging plant-pathogenic bacterium causing disease symptoms in a variety of agriculturally relevant crop species worldwide. To date, a number of D. solani genomes have been sequenced and characterized; the great majority of these genomes have, however, come from D. solani strains isolated from potato (Solanum tuberosum L.) and not from other plant hosts. Herewith, we present the first complete, high-quality genome of D. solani IPO 2019 (LMG 25990), isolated from the ornamental plant Hyacinthus orientalis. The genome of D. solani IPO 2019 consists of one chromosome of 4,919,542 bp, with a GC content of 56.2% and no plasmids. The genome contains 4,502 annotated features, 22 ribosomal RNA genes, 73 transfer RNA genes, and one CRISPR. We believe that the information on this high-quality, complete, closed genome of D. solani strain isolated from a host plant different from potato (i.e. hyacinth) will provide resources for comparative genomic studies and for analyses targeting adaptation and ecological fitness mechanisms present in Dickeya solani species. [Formula: see text] Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Ready-to-Use Micronized Human Acellular Dermal Matrix to Accelerate Wound Healing in Diabetic Foot Ulcers: A Prospective Randomized Pilot Study
Authors: Hahn Hyung Min , Lee Dong Hwan , Lee Il Jae 
Published: April 2021

ABSTRACT

OBJECTIVE
To examine and report clinical outcomes of a ready-to-use micronized dermal matrix for diabetic foot ulcers (DFUs) and compare it to treatment with conventional negative-pressure wound therapy (NPWT) only.

METHODS
The researchers randomly allocated 30 DFUs Wagner grade 2 or higher from 30 adult patients into two groups. The control group (n = 15) was treated with conventional NPWT, and the experimental group (n = 15) was treated with micronized dermal matrix and NPWT. The researchers evaluated the following outcomes: granulation tissue formation, proportion of patients with closed or granulated wounds at 42 and 120 days, achievement of complete wound healing in the 6 months of follow-up, and intervals from enrollment to final surgical procedures.

RESULTS
All 15 wounds treated with the micronized matrix showed healthy granulation tissue without noticeable complications during follow-up. At 42 days, 46.7% of wounds in the experimental group had closed compared with 28.6% in the conventional NPWT group (P = .007). At 120 days, 86.7% of the experimental group had completely closed wounds, compared with 57.1% in the conventional therapy group (P = .040). During the 6-month follow-up period, 93.3% of the experimental group achieved complete wound healing compared with 85.7% of the conventional therapy group (P = .468).

CONCLUSIONS
The healing outcomes for DFUs in the experimental group were superior when micronized matrix treatment was combined with NPWT.
The effect of high-dose versus low-dose epidural fentanyl on gastric emptying in nonfasted parturients
Authors: Fiszer Elisheva , Aptekman Boris , Baar Yuval , Weiniger Carolyn F. 
Published: April 2021

BACKGROUND
Epidural fentanyl doses above 100 μg have been shown, using the paracetamol absorption test, to reduce gastric emptying in fasted labouring women.

OBJECTIVE
To investigate the effect of fentanyl dose on gastric emptying in nonfasted labouring women using gastric ultrasonography.

DESIGN
A double-blinded randomised controlled study.

SETTING
A tertiary medical centre in Tel Aviv, Israel between 30 July 2020 and 11 October 2020.

PATIENTS
Eighty labouring women with cervical dilation 5 cm or less, at least 18 years age, at least 37 weeks gestation with a singleton pregnancy and cephalad foetus.

INTERVENTIONS
Women randomised to high (>100 μg) or low (<100 μg) cumulative epidural fentanyl had ultrasound gastric content assessment, measuring antral cross-sectional area (CSA) at epidural placement and 2 h thereafter (T
2
h).

MAIN OUTCOME MEASURES
The primary outcome was CSA at T
2
h comparing high-dose versus low-dose fentanyl. Secondary outcomes included change in CSA between baseline and T
2
h. Sub-group analysis compared stomach content at T
2
h according to baseline stomach content, empty (CSA <381 mm2) or full (CSA ≥381 mm2), and high-dose versus low-dose fentanyl.

RESULTS
Data from 80 women were analysed; 63 had empty and 17 had full stomach at baseline. There was no significant difference in CSA at T
2
h between high-dose, mean 335 ± SD 133 mm2, versus low-dose fentanyl, mean 335 ± SD 172 mm2, P = 0.991. Change in CSA baseline to T
2
h was 46 ± SD 149 mm2 for high and 49 ± SD 163 mm2 for low-dose group, P = 0.931. The subgroup analysis according to baseline stomach content showed no statistically significant differences in CSA at T
2
h.

CONCLUSION
The CSA at T
2
h was similar for women who received high-dose versus low-dose epidural fentanyl, measured by ultrasound, in our nonfasted labouring cohort.

TRIAL REGISTRATION
Clinicaltrials.gov number: NCT04202887.
Non-shoulder Injuries in Swimming: A Systematic Review
Authors: Hill Lee , Mountjoy Margo , Miller Jim 
Published: April 2021

Objective:
The shoulder is the most common injury in swimming, followed by the knee and spine. The repetitive nature of swimming training may predispose a swimmer to injury. Several risk factors have been previously identified, but the level of evidence and level of certainty that these risk factors predispose a swimmer to injury risk has yet to be evaluated critically in a systematic review.

Design:
Systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Data Sources:
Data were obtained through PubMed, Cochrane, and Google Scholar. The database search was limited to articles that were published between January 1980 and December 2019.

Eligibility Criteria for Selecting Studies:
Level I, II, and III studies were included in this review. All studies must have been conducted in swimmers or swimming, a description of the specific pathology and provide at least one identified risk factor with an association (P < 0.05).

Results:
A total of 19 critically appraised articles identified 28 potential risk factors for musculoskeletal injuries in swimmers. The risk factors were grouped by the anatomical region: neck and back, pelvis and hip, and the knee. Only 2 risk factors were appraised at a moderate level of certainty, both occurring in the knee. The remaining 26 identified risk factors were appraised at a low level of certainty. There is a clear lack of research surrounding nonshoulder injuries in swimmers.
Hepatopulmonary syndrome delays postoperative recovery and increases pulmonary complications after hepatectomy
Authors: Li Yu-jie , Bai Xue-hong , Tang Xi , Yang Zhi-yong , Wang Dan-dan , Hu Xiao-yan , Li Peng , Gu Jian-teng , Lu Kai-zhi , Belguise Karine , Wang Xiao-bo , Yu Wei-feng , Yang Li-qun , Xia Zheng-yuan , Yi Bin 
Published: April 2021

Background
This study attempted to investigate the impact of hepatopulmonary syndrome (HPS) on postoperative outcomes in hepatitis B virus-induced hepatocellular carcinoma (HBV-HCC) patients.

Methods
HBV-HCC patients undergoing primary curative hepatectomy for HCC in our hospital were diagnosed with HPS by contrast-enhanced echocardiography (CEE) and arterial blood gas analysis. Patients were divided into HPS, intrapulmonary vascular dilation (IPVD) (patients with positive CEE results and normal oxygenation) and control (patients with negative CEE results) groups. Baseline information, perioperative clinical data and postoperative pulmonary complications (PPCs) were compared among all groups. Cytokines in patient serums from each group (n = 8) were also assessed.

Results
Eighty-seven patients undergoing hepatectomy from October 2019 to January 2020 were analyzed. The average time in the postanaesthesia care unit (112.10 ± 38.57 min) and oxygen absorption after extubation [34.0 (14.5–54.5) min] in the HPS group was longer than in IPVD [81.81 ± 26.18 min and 16.0 (12.3–24.0) min] and control [93.70 ± 34.06 min and 20.5 (13.8–37.0) min] groups. There were no significant differences in oxygen absorption time after extubation between HPS and control groups. The incidence of PPCs, especially bi-lateral pleural effusions in the HPS group (61.9%), was higher than in IPVD (12.5%) and control (30.0%) groups. Increased serum levels of the growth-regulated oncogene, monocyte chemoattractant protein, soluble CD40 ligand and interleukin 8 might be related to delayed recovery in HPS patients.

Conclusions
HPS patients with HBV-HCC suffer delayed postoperative recovery and are at higher risk for PPCs, especially bi-lateral pleural effusions, which might be associated with changes in certain cytokines.
Changes in disease behaviour and location and factor analysis in patients with Crohn’s disease undergoing repeated-resections
Authors: Li Tao , Gao Lei , Cao Lei , Guo Zhen , Qian Wenwei , Yin Yi , Li Yi , Zhu Weiming 
Published: April 2021

Aim
Crohn’s disease affects the entire gastrointestinal tract and is accompanied by changes in disease location and behaviour. We aimed to analyse changes and the factors in patients with Crohn’s disease undergoing intestinal repeated-resection.

Methods
We included and retrospectively analyzed patients with Crohn’s disease who received ≥2 bowel surgeries from a tertiary inflammatory bowel disease centre from January 2008 to December 2019. The Montreal classification was used to describe the disease site and behaviour. Factors were assessed by univariate and multivariate analysis.

Results
A total of 339 patients were included of whom 94 patients received ≥3 bowel resections. The median patient’s age at the second and third surgery was 36.4 and 39.6, respectively. Repeated-resection most commonly occurred in the original surgical site. However, disease behaviour progressed with the number of surgical interventions and disease duration, especially for patients with B1 phenotype. Patients with L1 Crohn’s disease at a primary resection that progressed to L2 Crohn’s disease at a second surgical resection required a resection earlier than patients whose disease remained in L1 or progressed to L3 Crohn’s disease. Multivariate analysis showed that history of appendectomy was a predictor of progression from L1 to L3 Crohn’s disease at a second surgical resection, while treatment with azathioprine (AZA) may be a protective factor that abated the risk of progression from L1 to L3 Crohn’s disease.

Conclusion
The original resection site is the most common location for recurrence in patients with Crohn’s disease, but disease behaviour progresses with the number of surgeries and disease duration. L1 Crohn’s disease patients with a history of appendectomy have a higher risk to progress to L3 Crohn’s disease at a second surgical resection, while the AZA may be a protective factor that reduces the risk of progression from L1 to L3.
Neurally Adjusted Ventilator Assist in Infants With Acute Respiratory Failure: A Literature Scoping Review
Authors: Harris Julia , Tibby Shane M , Endacott Ruth , Latour Jos M. 
Published: April 2021

OBJECTIVES:
To map the evidence for neurally adjusted ventilatory assist strategies, outcome measures, and sedation practices in infants less than 12 months with acute respiratory failure using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidance.

DATA SOURCES:
CINAHL, MEDLINE, COCHRANE, JBI, EMBASE, PsycINFO, Google scholar, BNI, AMED. Trial registers included the following: ClinicalTrials.gov, European Union clinical trials register, International Standardized Randomized Controlled Trial Number register. Also included were Ethos, Grey literature, Google, dissertation abstracts, EMBASE conference proceedings.

STUDY SELECTION:
Abstracts were screened followed by review of full text. Articles incorporating a heterogeneous population of both infants and older children were assessed, and where possible, data for infants were extracted. Fifteen articles were included. Ten articles were primary research: randomized controlled trial (n = 3), cohort studies (n = 4), retrospective data analysis (n = 2), case series (n = 1). Other articles are expert opinion (n = 2), neurally adjusted ventilatory assist updates (n = 1), and a literature review (n = 2). Three studies included exclusively infants. We also included 12 studies reporting jointly on infants and children.

DATA EXTRACTION:
A standardized data extraction tool was used.

DATA SYNTHESIS:
Key findings were that evidence related to neurally adjusted ventilatory assist ventilation strategies in infants and related to specific primary conditions is limited. The setting of neurally adjusted ventilatory assist level is not consistent, and how to optimize this mode of ventilation was not documented. Outcome measures varied considerably, most studies focused on improvements in respiratory and physiological variables. Sedation use is variable with regard to medication type and dose. There is an indication that less sedation is required in patients receiving neurally adjusted ventilatory assist, but no conclusive evidence to support this.

CONCLUSIONS:
This review highlights a lack of standardized strategies for neurally adjusted ventilatory assist ventilation and sedation practices among infants with acute respiratory failure. Studies were limited by small sample sizes and a lack of focus on specific patient groups. Robust studies are needed to provide evidence-based clinical recommendations for the use of neurally adjusted ventilatory assist in infants with acute respiratory failure.
Functional Impairments and Rehabilitation Outcomes of Patients With Immunotherapy-Induced Acute Inflammatory Demyelinating Polyradiculoneuropathy, Myasthenia Gravis, and Myositis
Authors: Ng Amy H. , Molinares Diana M. , Guo Ying , Fu Jack , Bruera Eduardo 
Published: April 2021

Abstract
Immunotherapy has led to a higher survival rate among different oncological disease groups but also associated with adverse-related events in multiple organ systems. Immunotherapy-related musculoskeletal weakness often results in a loss of cancer survivors’ physical function, ultimately impacting their independence and quality of life. This is a retrospective study of 24 cancer patients who were treated with immunotherapy either alone or in conjunction with other oncological treatments. Twelve subjects (50%) were found to have acute inflammatory demyelinating polyradiculopathy/Guillain-Barré syndrome, six (25%) myositis, two (8%) myasthenia gravis, two (8%) diagnosis of myositis/myasthenia gravis, and one (4%) Guillain-Barré syndrome/myasthenia gravis combination. Physical therapy was provided in 91.7% of the cases, and physiatrist was involved in 54% of the cases. Almost half (45%) were discharged home, six (25%) to acute inpatient rehabilitation, two (8%) to subacute rehabilitation, three (12.5%) to hospice, and two (8%) died. The average length of hospital stay was 30 days, and eight patients (33%) readmitted within 3 mos. Our findings highlight the severity of functional impairments and the need for early rehabilitation interventions.
Readmission following surgical stabilization of rib fractures: Analysis of incidence, cost, and risk factors using the Nationwide Readmissions Database
Authors: Aalberg Jeffrey J. , Johnson Benjamin P. , Hojman Horacio M. , Rattan Rishi , Arabian Sandra , Mahoney Eric J. , Bugaev Nikolay 
Published: April 2021

BACKGROUND
Surgical stabilization of rib fractures (SSRF) has become increasingly common for the treatment of traumatic rib fractures; however, little is known about related postoperative readmissions. The aims of this study were to determine the rate and cost of readmissions and to identify patient, hospital, and injury characteristics that are associated with risk of readmission in patients who underwent SSRF. The null hypotheses were that readmissions following rib fixation were rare and unrelated to the SSRF complications.

METHODS
This is a retrospective analysis of the 2015 to 2017 Nationwide Readmission Database. Adult patients with rib fractures treated by SSRF were included. Univariate and multivariate analyses were used to compare patients readmitted within 30 days with those who were not, based on demographics, comorbidities, and hospital characteristics. Financial information examined included average visit costs and national extrapolations.

RESULTS
A total of 2,522 patients who underwent SSRF were included, of whom 276 (10.9%) were readmitted within 30 days. In 36.2% of patients, the reasons for readmissions were related to complications of rib fractures or SSRF. The rest of the patients (63.8%) were readmitted because of mostly nontrauma reasons (32.2%) and new traumatic injuries (21.1%) among other reasons. Multivariate analysis demonstrated that ventilator use, discharge other than home, hospital size, and medical comorbidities were significantly associated with risk of readmission. Nationally, an estimated 2,498 patients undergo SSRF each year, with costs of US $176 million for initial admissions and US $5.9 million for readmissions.

CONCLUSION
Readmissions after SSRF are rare and mostly attributed to the reasons not directly related to sequelae of rib fractures or SSRF complications. Interventions aimed at optimizing patients’ preexisting medical conditions before discharge should be further investigated as a potential way to decrease rates of readmission after SSRF.

LEVEL OF EVIDENCE
Epidemiological study, level III.