bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distress and wellbeing among 1.5‐generation immigrants 3 decades after immigration to Israel
Authors: Cohen‐Louck Keren , Shechory‐Bitton Mally 
Published: August 2021

AbstractThe aim of the study was to examine psychological adaptation levels (distress and wellbeing) and their association to acculturation strategies among 1.5 generation immigrants from Ethiopia and the former Soviet Union (FSU), 3 decades after large waves of immigrants from these countries came to Israel. Three‐hundred and forty‐one participants, 176 from Ethiopia and 165 from FSU, completed survey questionnaires assessing their acculturation attitudes and the levels of their wellbeing and stress. Personal wellbeing and distress were found to be moderate among all participants. In addition, while no ethnic group differences were found for integration, separation and marginalization, FSU immigrants reported higher levels of using assimilation strategies than those who came from Ethiopia. Regression findings show that personal wellbeing was significantly explained by the acculturation strategies of integration and marginalization, such that a greater use of integration and a lower use of marginalization were associated with higher personal wellbeing. The adaptation process in which immigrant groups adapt to a host society is dynamic, takes many years and the acculturation strategies change over time. The change is related to attitudes toward the destination culture and to the culture of origin, both among the immigrants and the host society.
A discontinuous cantilever beam analogy for quantifying higher mode demands in stacked rocking cores
Authors: Rahgozar Navid , Rahgozar Nima , Rahgozar Nooshin 
Published: August 2021

SummaryStacked rocking core (SRC) combinations are innovative sustainable structural assemblies that mitigate seismic demands through uplift at the hinge joints and direct damage to replaceable fuses. The stacked segments curtail substantially higher mode effects by the relative motions between multilevel cores. Currently, few research studies have quantified the behavior of SRCs under earthquake shaking. This paper presents a novel closed‐form solution for quantifying the higher mode demands of stacked braced frames subjected to seismic excitation. The mathematical formulae for modal analysis are derived using the analogy of discontinuous cantilever beam and Euler–Bernoulli equation. The proposed equations provide a method for rapid analysis and preliminary design of low‐ to mid‐rise SRCs. A parametric study is carried out to investigate the influences of rotational restraint of segments and the location of the rocking joints. Results verified by time response analysis indicate the validity and accuracy of the suggested formulae.
Free Amine, Hydroxyl and Sulfhydryl Directed C−H Functionalization and Annulation: Application to Heterocycle Synthesis
Authors: Kumar Sandeep , Kumar Akshay , Sharma Dharminder , Das Pralay 
Published: August 2021

AbstractTransition metal‐catalyzed direct C−H bond functionalization is recognized as an efficient strategy to assemble heterocyclic frameworks. For this purpose, directing groups (DGs) installation on an organic molecule has remained a widely exploited strategy for the years. The installation of directing groups, especially for the amine, alcohol and thiol containing reactants and their removal after the reaction need additional steps. In this regard, the use of free amine, hydroxyl and sulfhydryl as directing groups in native form is advantageous and in recent times, these transformations have stirred undisputable advancements for applications to heterocycle synthesis. In this review, the aromatic sp2‐C attached free amine, hydroxyl and sulfhydryl as native functionalities are shown to be useful for the construction of five to seven‐memberedN‐,O‐ andS‐heterocycles.
The significance of fluorescence in transmission X‐ray absorption spectroscopy and X‐ray absorption fine structure
Authors: Sier Daniel , Ekanayake Ruwini Supeshala Kumari , Chantler Christopher Thomas 
Published: August 2021

We present a method to explore the effect of fluorescence on X‐ray attenuation measurements obtained from X‐ray absorption spectroscopy (XAS). We use the X‐ray extended range technique‐like method (XERT‐like). The experimental setup includes different sized apertures to control the number of secondary X‐rays entering the detector. Comparison of attenuation measurements produced with different aperture combination permit investigation of the effect of fluorescence radiation. In this work, fluorescence has a large impact on the attenuation measurements of thick zinc foils. The correction is energy‐dependent and sample thickness‐dependent and changes the structure and relative amplitudes of oscillations in the near‐edge region. Correction for this systematic is important for absolute measurement, for edge‐jump and edge characterization, and for near‐edge structure and amplitudes. A significant background scattering due to zinc fluorescence from the beamline optics was identified and treated for the first time. The model theory fits the experimental measurements well. The resulting correction is most significant for thicker foils with the 50 μm sample experiencing a shift in attenuation of up to 15.5% for the largest aperture while the 25 and 10 μm samples saw corrections of up to 0.153 and 0.00639% respectively. The standard error from the dispersion and variance was reduced by up to 50.5% after the correction for the 50 μm sample. This enables high‐accuracy data and theoretical and experimental analysis to below 0.03% accuracy. The technology is advanced. There is a cost in preparation and measurement time of less than a factor of two, and the principles are clear and can be routinely implemented on any beamline. This paper focuses on the model and parameters for fluorescence.
Cryopreservation of Potato Shoot Tips for Long-Term Storage
Authors: Vollmer Rainer , Espirilla Janeth , Villagaray Rosalva , Cárdenas José , Castro Mario , Sánchez Juan Carlos , Manrique-Carpintero Norma , Ellis David , Anglin Noelle Lynette 
Published: August 2021

AbstractCryopreservation is currently the only method which allows long-term conservation of living clonal plant material in the vapor or liquid phase of nitrogen (at −140 to −196 °C) allowing tissue to be viable for decades or perhaps centuries. Specifically, for species with recalcitrant seeds or requiring constant vegetative propagation, it is the method of choice for the long-term conservation of its genetic resources. The protocol described here is a modification of a previously developed plant vitrification solution 2 (PVS2)—droplet vitrification method of potato shoot tips, adapted from Musa species. Utilizing this protocol, the International Potato Center (CIP) has successfully stored in the cryobank more than 3000 cultivated potato accessions, belonging to seven species and nine different taxa [16], originating principally from ten countries in South and Central America. As part of CIP’s quality management system, all vegetative material placed in cryo is routinely subsampled, thawed, and assessed to confirm that whole plantlets can be produced after storage in liquid nitrogen. Complete plant recovery rates of thawed shoot tips range from 20% to 100% (average rate: 60%). This chapter describes the complete set of steps from the routine procedure of cryopreserving potato shoot tips for long-term conservation.
Non-relativistic and potential non-relativistic effective field theories for scalar mediators
Authors: Biondini Simone , Shtabovenko Vladyslav 
Published: August 2021

AbstractYukawa-type interactions between heavy Dirac fermions and a scalar field are a common ingredient in various extensions of the Standard Model. Despite of that, the non-relativistic limit of the scalar Yukawa theory has not yet been studied in full generality in a rigorous and model-independent way. In this paper we intend to fill this gap by initiating a series of investigations that make use of modern effective field theory (EFT) techniques. In particular, we aim at constructing suitable non-relativistic and potential non-relativistic EFTs of Yukawa interactions (denoted as NRY and pNRY respectively) in close analogy to the well known and phenomenologically successful non-relativistic QCD (NRQCD) and potential non-relativistic QCD (pNRQCD). The phenomenological motivation for our study lies in the possibility to explain the existing cosmological observations by introducing heavy fermionic dark matter particles that interact with each other by exchanging a light scalar mediator. A systematic study of this compelling scenario in the framework of non-relativistic EFTs (NREFTs) constitutes the main novelty of our approach as compared to the existing studies.
Hadronic decays of Higgs boson at NNLO matched with parton shower
Authors: Hu YaLu , Sun ChuanLe , Shen XiaoMin , Gao Jun 
Published: August 2021

Abstract
We present predictions for hadronic decays of the Higgs boson at next-to-next-to-leading order (NNLO) in QCD matched with parton shower based on the POWHEG framework. Those include decays into bottom quarks with full bottom-quark mass dependence, light quarks, and gluons in the heavy top quark effective theory. Our calculations describe exclusive decays of the Higgs boson with leading logarithmic accuracy in the Sudakov region and next-to-leading order (NLO) accuracy matched with parton shower in the three-jet region, with normalizations fixed to the partial width at NNLO. We estimated remaining perturbative uncertainties taking typical event shape variables as an example and demonstrated the need of future improvements on both parton shower and matrix element calculations. The calculations can be used immediately in evaluations of the physics performances of detector designs for future Higgs factories.
Integrable structure of BCD conformal field theory and boundary Bethe ansatz for affine Yangian
Authors: Litvinov Alexey , Vilkoviskiy Ilya 
Published: August 2021

Abstract
In these notes we study integrable structures of conformal field theory with BCD symmetry. We realise these integrable structures as $$ \mathfrak{gl} $$
gl
(1) affine Yangian “spin chains” with boundaries. We provide three solutions of Sklyanin KRKR equation compatible with the affine Yangian R-matrix and derive Bethe ansatz equations for the spectrum. Our analysis provides a unified approach to the integrable structures with BCD symmetry including superalgebras.
Abklärung von blutigem Urin
Authors: Krämer J. , Krämer S. 
Published: August 2021

ZusammenfassungEin 3‑jähriges Mädchen wird in der pädiatrischen Stoffwechselambulanz vorgestellt, da seit einigen Monaten im Rahmen der Sauberkeitsentwicklung dunkle Urinverfärbungen aufgefallen sind. Die ausführliche Abklärung bezüglich einer Porphyrie und Hämaturie führte nicht zur Diagnosestellung. Die beim Kinderarzt abgegebenen Urinproben waren jeweils unauffällig. Im Rahmen der spezifischen Diagnostik zeigten sich eine erhöhte Homogentisatausscheidung im Urin und damit die Diagnosestellung einer Alkaptonurie. Es wurde eine spezifische Therapie eingeleitet, um Gelenkschädigungen durch pathologische Ablagerungen zu reduzieren. Die weitere Prognose bleibt unklar.
Reducing the geometrical machining errors incurred during die repair and maintenance through electric discharge machining (EDM)
Authors: Ishfaq Kashif , Farooq Muhammad Umar , Pruncu Catalin I. 
Published: August 2021

AbstractThe importance of geometrical accuracy can never be overruled in dies and molds which governs the dimensional precision of the parts being manufactured. The continuous use of such tooling requires repair and maintenance. Among the different processes used to upkeep the dimensional consistency of the tooling, machining is essentially required in most cases. The intricacy of the dies and molds’ cavities requires the use of electric discharge machining (EDM). However, in EDM it is challenging to develop control over the machined dimensions owing to the inherent issues of overcut/undercut. This aspect was not comprehensively investigated so far which is the core focus of this research. Three electrode materials, namely, copper, graphite, and tungsten carbide, which belong to the category of metals, nonmetals, and ceramics, respectively, have been compared for the said perspective on the comprehensive list of parametric variables. The results revealed that the average value of the axial errors is 2.5 times lesser in comparison to lateral dimensional errors. In the case of lateral dimensional errors, the electrode of graphite has proved to be a promising choice in comparison to the other two types of electrode materials, namely, copper and tungsten carbide. The copper electrode is noticed to be the most appealing option for reducing axial error (A.E). The mean A.E obtained with Cu electrode is 80.9% and 47.6% lower than that achieved in case graphite and tungsten carbide, respectively. Furthermore, the optimal parametric combination based on 7 variables has also been proposed using desirability analyses whose validity is proved during confirmation trials.
Behavioural and electrophysiological correlates of lightness contrast and assimilation
Authors: Acaster Stephanie L. , Taroyan Naira A. , Soranzo Alessandro , Reidy John G. 
Published: August 2021

AbstractLightness contrast and assimilation are opposite phenomena: in contrast grey targets appear darker when bordering bright rather than dark surfaces; in assimilation grey targets appear lighter when bordering bright rather than dark surfaces. The underlying neurophysiological mechanisms of these phenomena are not known. The aim of this study was to investigate the relationship between contrast and assimilation, and the timing and levels of perceptual and cognitive processing using combined behavioural and electrophysiological methods. Thirty undergraduate students (23 female, age range 18–48 years) participated in a forced-choice (grey target is lighter/darker than a comparison square) task, using stimuli designed such that the inducers were in two configurations (small and large) and two shades (white and black). The behavioural data (more consistent and faster responses) corroborated previous findings of stronger contrast effects with white inducers and stronger assimilation effects with black inducers. According to the Event-Related Potentials (ERP) results the mean amplitude was larger in conditions with less consistent and slower behavioural responses. Thus, with contrast responses P1 amplitude was larger with black than white inducers, and N1 amplitude was larger to assimilation than contrast when the configuration of the stimulus was held constant. These results suggest contrast may occur as early as P1 (~ 110 ms) and assimilation may occur later in N2 (~ 220 ms), whereas in some conditions, differences in ERPs associated with contrast vs assimilation may happen as early as in N1 (~ 170 m), in occipital and parietal cortical sites.
Risk identification and technical modifications reduce the incidence of post-cholecystectomy bile leakage: analysis of 5675 laparoscopic cholecystectomies
Authors: Nassar Ahmad H. M. , Ng Hwei Jene 
Published: August 2021

Abstract
Purpose
The main sources of post-cholecystectomy bile leakage (PCBL) not involving major duct injuries are the cystic duct and subvesical/hepatocystic ducts. Of the many studies on the diagnosis and management of PCBL, few addressed measures to avoid this serious complication. The aim of this study was to examine the causes and mechanisms leading to PCBL and to evaluate the effects of specific preventative strategies.

Methods
A prospectively maintained database of 5675 consecutive laparoscopic cholecystectomies was analysed. Risk factors for post-cholecystectomy bile leakage were identified and documented and technical modifications and strategies were adopted to prevent this complication. The incidence, causes and management of patients who suffered bile leaks were studied and their preoperative characteristics, operative data and postoperative outcomes were compared with patients where potential risks were identified and PCBL avoided and with the rest of the series.

Results
Twenty-five patients (0.4%) had PCBL (7 expected and less than half requiring reintervention): 11 from cystic ducts (0.2%), 3 from subvesical ducts (0.05%) and 11 from unconfirmed sources (0.2%). The incidence of cystic duct leakage was significantly lower with ties (0.15%) than with clips (0.7%). Fifty-two percent had difficulty grades IV or V, 36% had empyema or acute cholecystitis and 16% had contracted gallbladders. Twelve patients required 17 reinterventions before PCBL resolved; 7 percutaneous drainage, 6 ERCP and 4 relaparoscopy. The median hospital stay was 17 days with no mortality. Hepatocystic ducts were encountered in 72 patients (1.3%) and were secured with loops (54.2%), ties (25%) or sutures (20.8%) with no PCBL. Eighteen sectoral ducts were identified and secured.

Conclusion
Ligation of the cystic duct reduces the incidence of PCBL resulting from dislodged endoclips. Careful blunt dissection in the proper anatomical planes avoiding direct or thermal injury to subvesical and sectoral ducts and a policy of actively searching for hepatocystic ducts during gallbladder separation to identify and secure them can reduce bile leakage from such ducts.
Molecular diagnostics and therapies for gastrointestinal tumors: a real-world experience
Authors: Welland Sabrina , deCastro Tiago , Bathon Melanie , Wirth Thomas Christian , Reineke-Plaaß Tanja , Saborowski Michael , Lehmann Ulrich , Saborowski Anna , Vogel Arndt 
Published: August 2021

Abstract
Purpose
Several targeted agents demonstrated efficacy in early clinical trials for gastrointestinal (GI) cancers, but in many cases, phase-III trials and/or approval by the European Medicines Agency (EMA) are lacking. The primary focus of this study was to assess the regulatory processes associated with use and reimbursement of off-label treatment in precision oncology and to evaluate the benefit of targeted therapy in a real-world population in Germany.

Methods
Our cohort comprises 137 patients with GI cancers and is biased towards cancer entities with a high frequency of known targetable alterations, such as cholangiocarcinoma. Genetic testing was used to identify molecular targets, and therapy response was evaluated based on CT scans.

Results
A molecular target for precision oncology was identified in 53 patients and 43 requests for cost coverage were submitted to health insurance companies. 60% of the requests received approval after initial application and another 7% after appeal. Half of the rejected requests were denied despite ESCAT IA level evidence. The median time between initiation of molecular testing and start of therapy was 75 days. 35 patients received matched targeted therapies (n = 28) or, in the case of MSI, immunotherapy (IO) (n = 7). We observed a trend in favor of molecular therapy when compared to the immediate prior treatment.

Conclusion
Relevant treatment options were identified by molecular testing in a significant subset of patients. When targeted therapies that lack EMA approval are considered, treatment initiation may be delayed by the duration of the molecular analysis and the regulatory processes.
Reductions in biomarkers of exposure to selected harmful and potentially harmful constituents following exclusive and partial switching from combustible cigarettes to myblu™ electronic nicotine delivery systems (ENDS)
Authors: Morris Paul , McDermott Simon , Chapman Fiona , Verron Thomas , Cahours Xavier , Stevenson Matthew , Thompson Joseph , Chaudhary Nveed , O’Connell Grant 
Published: August 2021

AbstractElectronic nicotine delivery systems (ENDS) offer adult combustible cigarette smokers an alternative, potentially reduced harm, mode of nicotine delivery, attributed to fewer and reduced levels of harmful and potentially harmful constituents (HPHCs) in their aerosols compared to cigarette smoke. These two identical, randomised, open label, two-part studies aimed to compare levels of 15 biomarkers of exposure (BoE) to selected HPHCs associated with tobacco smoking in healthy US adult smoker subjects (n = 72). Following 9 days of exclusive use of a range of allocated myblu™ ENDS variants, subjects’ levels of 14 non-nicotine BoE were substantially reduced compared to baseline values (combustible cigarette use), in the range of 46–97%. BoE reductions were sustained in subjects who continued myblu use exclusively (n = 25) for a further 5 days, and returned to near baseline levels in subjects who returned to exclusive combustible cigarette use (n = 21). Dual users (n = 24) demonstrated reductions in BoE to a lesser extent than with exclusive myblu use. Measured nicotine equivalents did not significantly change throughout the study. These data suggest exclusive use of ENDS provides adult smokers seeking an alternative to combustible cigarettes with substantial reductions in HPHC exposures whilst achieving satisfying levels of nicotine delivery. Dual use involving substitution of cigarettes may also provide some of this advantage, but to lesser extent. Overall, the data contribute to the weight of evidence that ENDS are an important tool in tobacco harm reduction for adult smokers unwilling to or uninterested in quitting smoking. Study 1: NCT 04430634, study 2: NCT 04429932, clinicaltrials.gov (10-06-2020).
Low sclerostin levels after long-term remission of acromegaly
Authors: Claessen Kim M. J. A. , Pelsma Iris C. M. , Kroon Herman M. , van Lierop Antoon H. , Pereira Alberto M. , Biermasz Nienke R. , Appelman-Dijkstra Natasha M. 
Published: August 2021

Abstract
Purpose
Bone health is compromised in acromegaly resulting in vertebral fractures (VFs), regardless of biochemical remission. Sclerostin is a negative inhibitor of bone formation and is associated with increased fracture risk in the general population. Therefore, we compared sclerostin concentrations between well-controlled acromegaly patients and healthy controls, and assessed its relationship with bone mineral density (BMD), and VFs in acromegaly.

Methods
Seventy-nine patients (mean age 58.9 ± 11.4 years, 49% women) with controlled acromegaly, and 91 healthy controls (mean age 51.1 ± 16.9 years, 59% women) were included. Plasma sclerostin levels (pg/mL) in patients were measured with an ELISA assay, whereas in controls, serum levels were converted to plasma levels by multiplication with 3.6. In patients, VFs were radiographically assessed, and BMD was assessed using dual X-ray absorptiometry.

Results
Median sclerostin concentration in controlled acromegaly patients was significantly lower than in healthy controls (104.5 pg/mL (range 45.7–234.7 pg/mL) vs 140.0 pg/mL (range 44.8–401.6 pg/mL), p < 0.001). Plasma sclerostin levels were not related to age, current growth hormone (GH) or insulin-like factor-1 (IGF-1) levels, gonadal state, treatment modality, remission duration, or BMD, VF presence, severity or progression.

Conclusion
Patients with long-term controlled acromegaly have lower plasma sclerostin levels than healthy controls, as a reflection of decreased osteocyte activity. Further longitudinal studies are needed to establish the course of sclerostin during different phases of disease and its exact effects in acromegalic osteopathy.
„Da muss man dann auch mit zurechtkommen“
Authors: Clark Zoë , Maleyka Kathrin , Wohlfarth Arne 
Published: August 2021

ZusammenfassungSelbstorganisierte Interessenvertretungen junger Menschen in der Heimerziehung sollen ihnen ein selbstbestimmtes Leben durch Mitgestaltungsspielräume in ihrem Lebensumfeld ermöglichen. Deren Nutzung ist aber voraussetzungsvoll: Die Betroffenen müssen sich sowohl als Teil eines Kollektivs als auch als ein politisches Subjekt verstehen, das wirkmächtig Einfluss auf institutionelle und organisationale Prozesse nehmen kann. Die Praxis zeigt jedoch, dass die Aneignung dieser Voraussetzungen im Alltag der Heimerziehung durch Entfremdungsdynamiken verhindert wird. Der Beitrag kontextualisiert und analysiert solche Hindernisse.