bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mindful attention awareness and cognitive defusion are indirectly associated with less PTSD-like symptoms via reduced maladaptive posttraumatic cognitions and avoidance coping
Authors: Ito Daisuke , Watanabe Asuka , Osawa Kaori 
Published: February 2021

AbstractRecently, the effects of mindfulness-based interventions for posttraumatic stress disorder (PTSD) have been studied. However, we lack knowledge of the processes or mechanisms through which mindfulness influences resilience or promotes recovery following exposure to trauma. In this study, we examine the process by which mindfulness and cognitive-behavioral factors such as posttraumatic negative cognition and avoidance behaviors are associated with reduced PTSD-like symptoms. A questionnaire survey was conducted with 885 university students, using the Trauma Experience Questionnaire, Mindful Attention Awareness Scale, Cognitive Fusion Questionnaire, Post-Traumatic Stress Disorder Checklist, revised Ways of Coping Checklist, and a brief version of the Posttraumatic Cognitions Inventory. Data from 254 participants who experienced trauma with PTSD-like symptoms were analyzed. The final model using SEM indicated no direct association of mindful attention awareness on PTSD-like symptoms, a small direct association of cognitive defusion on PTSD-like symptoms, and a large indirect association mediated by posttraumatic negative cognitions and avoidance coping. Owing to the study’s cross-sectional design, strong conclusions cannot be drawn regarding the causal relationship of mindfulness and cognitive-behavioral factors or generalizations. However, our findings suggest that it would be worthwhile to continue to clarify the mechanism of mindfulness and to investigate its use in the treatment of PTSD. In the future, a highly accurate study design will hopefully be used to examine the mechanisms of several different factors associated with improvement in posttraumatic stress symptoms, preferably including them in the same model.
Feasibility of implementing a behavioral economics mobile health platform for individuals with behavioral health conditions
Authors: Granek Barry , Evans Aja , Petit Jorge , James Mary Crawford , Ma Yixuan (Matt) , Loper Matthew , Fuccillo Michael , Schmidt Rudy 
Published: February 2021

AbstractCoordinated Behavioral Care’s (CBC) Pathway Home™ (PH) program partnered with Wellth, Inc., a mobile health platform grounded in behavioral economics theory, to help individuals with behavioral health conditions build and reinforce health habits by providing daily reminders to take medication, requiring tasks (photos demonstrating remembrance), and providing financial incentives tied to behaviors. CBC made Wellth, Inc. available to individuals enrolling in its PH program for the purpose of demonstrating the feasibility of implementing a novel mobile technology grounded in behavioral economic theory to increase habits of health activities, such as taking medication, among adults with behavioral health conditions.
The effect of non-uniformity in ground motions on the seismic response of arch dams
Authors: Pouya Mohammad Reza , Sohrabi-Gilani Morteza , Ghaemian Mohsen 
Published: February 2021

AbstractRecorded ground accelerations at various locations of Karun III Dam during November 20, 2007, were recorded by an array of accelerometers located on the dam. In terms of amplitude and phase, these accelerations show non-uniformities in different elevations. In this paper, the effect of these non-uniform ground motions on the seismic response of the dam taking dam-reservoir-foundation interaction into account is investigated. The EACD-3D-2008 finite element program and ABAQUS Software are used for carrying out the seismic analyses. For this purpose, time histories of the earthquake accelerations are interpolated at nodal points located on the dam foundation interface. The analysis has been repeated, considering the common assumption of uniform ground motions. Comparing the results obtained from these two analyses reveals that the computed displacements in the crest due to the spatially varying excitations are in more conformity with the recorded information. Moreover, neglecting the non-uniform nature of ground motions in the model leads to underestimating the tensile stress values within the dam body.
On the Nature of Necessary Truths in Jurisprudence: Putting Wittgensteinian Hinges to Use
Authors: Tong Yi 
Published: February 2021

Inquiring into the fundamental nature of law has been traditionally formulated as an attempt to answer the question, “What is Law?” Such an inquiry typically proceeds by identifying the necessary features of law. Joseph Raz, for example, writes:
A theory consists of necessary truths, for only necessary truths about the law reveal the nature of the law. We talk of ‘the nature of law’, or the nature of anything else, to refer to those of the law’s characteristics which are of the essence of law, which make law into what it is. That is those properties without which the law would not be law.1
Stochastic comparisons and ageing properties of an extended gamma process
Authors: Al Masry Zeina , Mercier Sophie , Verdier Ghislain 
Published: February 2021

AbstractExtended gamma processes have been seen as a flexible extension of standard gamma processes in the recent reliability literature, for the purpose of cumulative deterioration modeling. The probabilistic properties of the standard gamma process have been well explored since the 1970s, whereas those of its extension remain largely unexplored. In particular, stochastic comparisons between degradation levels modeled by standard gamma processes and ageing properties for the corresponding level-crossing times are now well understood. The aim of this paper is to explore similar properties for extended gamma processes and see which ones can be broadened to this new context. As a by-product, new stochastic comparisons for convolutions of gamma random variables are also obtained.
Simple conditions for metastability of continuous Markov chains
Authors: Mangoubi Oren , Pillai Natesh , Smith Aaron 
Published: February 2021

AbstractA family $\{Q_{\beta}\}_{\beta \geq 0}$ of Markov chains is said to exhibit metastable mixing with modes$S_{\beta}^{(1)},\ldots,S_{\beta}^{(k)}$ if its spectral gap (or some other mixing property) is very close to the worst conductance $\min\!\big(\Phi_{\beta}\big(S_{\beta}^{(1)}\big), \ldots, \Phi_{\beta}\big(S_{\beta}^{(k)}\big)\big)$ of its modes for all large values of $\beta$. We give simple sufficient conditions for a family of Markov chains to exhibit metastability in this sense, and verify that these conditions hold for a prototypical Metropolis–Hastings chain targeting a mixture distribution. The existing metastability literature is large, and our present work is aimed at filling the following small gap: finding sufficient conditions for metastability that are easy to verify for typical examples from statistics using well-studied methods, while at the same time giving an asymptotically exact formula for the spectral gap (rather than a bound that can be very far from sharp). Our bounds from this paper are used in a companion paper (O. Mangoubi, N. S. Pillai, and A. Smith, arXiv:1808.03230) to compare the mixing times of the Hamiltonian Monte Carlo algorithm and a random walk algorithm for multimodal target distributions.
Lyapunov-type conditions for non-strong ergodicity of Markov processes
Authors: Mao Yong-Hua , Wang Tao 
Published: February 2021

AbstractWe present Lyapunov-type conditions for non-strong ergodicity of Markov processes. Some concrete models are discussed, including diffusion processes on Riemannian manifolds and Ornstein–Uhlenbeck processes driven by symmetric $\alpha$-stable processes. In particular, we show that any process of d-dimensional Ornstein–Uhlenbeck type driven by $\alpha$-stable noise is not strongly ergodic for every $\alpha\in (0,2]$.
Tail asymptotics for the area under the excursion of a random walk with heavy-tailed increments
Authors: Denisov Denis , Perfilev Elena , Wachtel Vitali 
Published: February 2021

AbstractWe study the tail behaviour of the distribution of the area under the positive excursion of a random walk which has negative drift and heavy-tailed increments. We determine the asymptotics for tail probabilities for the area.
Double hypergeometric Lévy processes and self-similarity
Authors: Kyprianou Andreas E. , Pardo Juan Carlos , Vidmar Matija 
Published: February 2021

AbstractMotivated by a recent paper (Budd (2018)), where a new family of positive self-similar Markov processes associated to stable processes appears, we introduce a new family of Lévy processes, called the double hypergeometric class, whose Wiener–Hopf factorisation is explicit, and as a result many functionals can be determined in closed form.
Business Model Innovation and Experimentation in Transforming Economies: ByteDance and TikTok
Authors: Ma Yulun , Hu Yue 
Published: February 2021

ABSTRACTFirms from transforming economies can leverage the characteristics of their location to develop innovative business models before internationalizing. This note showcases ByteDance's innovative business model for its TikTok app, which became one of the most downloaded apps globally. ByteDance used its large and increasingly demanding home market to experiment with creative combinations of business model elements to develop a unique business proposition that positions the TikTok app as a hybrid of social networking and video-sharing. In addition, TikTok benefitted from China's IT strength supported by national high-tech policy to an AI-based recommendation algorithm as a non-location bound resource. TikTok shows that firms from transforming economies can launch successful global products through business model innovation.
The Voice Gives It Away
Authors: Krahé Barbara , Uhlmann Andreas , Herzberg Meike 
Published: February 2021

Abstract. Two experiments examined the impact of voice pitch on gender stereotyping. Participants listened to a text read by a female (Study 1; N = 171) or male (Study 2, N = 151) speaker, whose voice pitch was manipulated to be high or low. They rated the speaker on positive and negative facets of masculinity and femininity, competence, and likability. They also indicated their own gendered self-concept. High pitch was associated with the ascription of more feminine traits and greater likability. The high-pitch female speaker was rated as less competent, and the high-pitch male speaker was perceived as less masculine. Text content and participants’ gendered self-concept did not moderate the pitch effect. The findings underline the importance of voice pitch for impression formation.
Toward Constraining Mars' Thermal Evolution Using Machine Learning
Authors: Agarwal S. , Tosi N. , Kessel P. , Padovan S. , Breuer D. , Montavon G. 
Published: February 2021

AbstractThe thermal and convective evolution of terrestrial planets like Mars is governed by a number of initial conditions and parameters, which are poorly constrained. We use Mixture Density Networks (MDN) to invert various sets of synthetic present‐day observables and infer five parameters: reference viscosity, activation energy and activation volume of the diffusion creep rheology, an enrichment factor for radiogenic elements in the crust, and initial mantle temperature. The data set comes from 6,130 two‐dimensional simulations of the thermal evolution of Mars' interior. We quantify the possibility of constraining a parameter using the log‐likelihood value from the MDN. Reference viscosity can be constrained to within 32% of its entire range (1019 − 1022 Pa s), when all the observables are available: core‐mantle‐boundary heat flux, surface heat flux, radial contraction, melt produced, and duration of volcanism. Furthermore, crustal enrichment factor (1–50) can be constrained, at best, to within 15%, and the activation energy (105 − 5 × 105 J mol−1) to within 80%. Initial mantle temperature can be constrained to within 39% of its range (1,600–1,800 K). Using the full present‐day temperature profile or parts of it as an observable tightens the constraints further. The activation volume (4 × 10−6 − 10 × 10−6 m3 mol−1) cannot be constrained. We also tested different levels of uncertainty in the observables and found that constraints on different parameters loosen differently, with initial temperature being the most sensitive. Finally, we present how a joint probability model for all parameters can be obtained from the MDN.
Gypsum Deltas at the Holocene Dead Sea Linked to Grand Solar Minima
Authors: Weber N. , Lazar B. , Gavrieli I. , Yechieli Y. , Stein M. 
Published: February 2021

AbstractUnique gypsum structures: large capes (termed “gypsum deltas”) and small pitted gypsum mounds are exposed along the western shores of the currently retreating Dead Sea, the hypersaline terminal lake in the Dead Sea Basin. The gypsum deltas were formed during time intervals of low lake stands (∼420 ± 10 m below mean sea level), when sulfate‐rich Ca chloride brines discharged from the coastal aquifer via saline springs, mixed with the Dead Sea brine and precipitated the gypsum (outsalting process). The ages of formation of the gypsum structures coincide with times of North Atlantic cooling events and grand solar minima suggesting a direct impact of the latter on the Dead Sea hydrology and high sensitivity of the regional hydrology (controlling lake level) to global solar‐related events. The temporal occurrence and numbers of the gypsum structures appear to follow the Hallstatt Cycle that approaches minima at ∼3,000–2,000 years before present.
Forecasting South China Sea Monsoon Onset Using Insight From Theory
Authors: Geen Ruth 
Published: February 2021

AbstractMonsoon onset over the South China Sea occurs in April–May, marking the start of the wet season over East Asia. Skillful prediction of onset timing remains an open challenge. Recently, theoretical studies using idealized models have revealed feedbacks at work during the seasonal transitions of the Hadley cells and have shown that these are relevant to monsoon onset over Asia. Here, I hypothesize that monsoon onset occurs earlier in years when the atmosphere over the South China Sea is already in a state where these feedbacks are more easily triggered. I find that local anomalies in lower‐level moist static energy in the preceding January–March are well correlated with South China Sea Monsoon onset timing. This relationship remains relatively consistent on decadal timescales, while correlations with other teleconnections vary, and is used to develop a simple forecast model for onset timing that shows skill competitive with that of more complex models.
The Lithospheric Architecture of Australia From Seismic Receiver Functions
Authors: Birkey Andrew , Ford Heather A. , Dabney Page , Goldhagen Gillian 
Published: February 2021

AbstractIn the past decade, mounting evidence has pointed to complex, layered structure within and at the base of the mantle lithosphere of tectonically quiescent continental interiors. Sometimes referred to as negative velocity gradients or midlithospheric discontinuities (MLDs), the origin of intralithospheric layering has prompted considerable discussion, particularly as to how they may result from continent formation and/or evolution. Previous Sp receiver function analysis in Australia (Ford et al., 2010, https://doi.org/10.1016/j.epsl.2010.10.007) found evidence for complex lithospheric layering beneath permanent stations located within the North, South, and West Australian Cratons and characterized these as MLDs. This study provides an update to the original study by Ford et al. (2010, https://doi.org/10.1016/j.epsl.2010.10.007). Sp receiver function results are presented for 34 permanent, broadband stations. We observe the lithosphere–asthenosphere boundary (LAB) on the eastern margin of the continent, at depths of 75–85 km. The cratonic core of Australia has discontinuities within the lithosphere, with no observable LAB. On the western margin of the continent, we observe several stations with an ambiguous phase that may correspond to an MLD or the LAB. We also observe multiple negative phases at most stations, suggesting a complex and heterogeneous lithosphere. Australian MLDs are likely linked to the presence of hydrous minerals in the midlithosphere and may result from ancient processes such as subduction, plume interaction, or melt infiltration from the paleo‐LAB.
In-field stereotactic body radiotherapy (SBRT) reirradiation for pulmonary malignancies as a multicentre analysis of the German Society of Radiation Oncology (DEGRO)
Authors: John Caroline , Dal Bello Riccardo , Andratschke Nicolaus , Guckenberger Matthias , Boda-Heggemann Judit , Gkika Eleni , Mantel Frederick , Specht Hanno M. , Stromberger Carmen , Zehentmayr Franz , Blanck Oliver , Balermpas Panagiotis 
Published: February 2021

AbstractData of thoracic in-field reirradiation with two courses of stereotactic body radiotherapy (SBRT) is scarce. Aim of this study is to investigate feasibility and safety of this approach. Patients with a second course of thoracic SBRT and planning target volume (PTV) overlap were analyzed in this retrospective, multicenter study. All plans and clinical data were centrally collected. 27 patients from 8 centers have been amenable for evaluation: 12 with non-small-cell lung cancer, 16 with metastases, treated from 2009 (oldest first course) to 2020 (latest second course). A median dose of 38.5 Gy to the 65%-isodose over a median of 5 fractions was prescribed in the first course and 40 Gy in 5 fractions for the second SBRT-course. Median PTV of the second SBRT was 29.5 cm3, median PTV overlap 22 cm3. With a median interval of 20.2 months between the two SBRT-courses, 1-year OS, and -LCR were 78.3% and 70.3% respectively. 3 patients developed grade 1 and one grade 2 pneumonitis. No grade > 2 toxicity was observed. Peripheral location and dose were the only factors correlating with tumor control. A second SBRT-course with PTV overlap appears safe and achieves reasonable local control.
Frame localisation optical projection tomography
Authors: Russell Craig T. , Vallejo Ramirez Pedro P. , Rees Eric 
Published: February 2021

AbstractWe present a tomographic reconstruction algorithm (flOPT), which is applied to Optical Projection Tomography (OPT) images, that is robust to mechanical jitter and systematic angular and spatial drift. OPT relies on precise mechanical rotation and is less mechanically stable than large-scale computer tomography (CT) scanning systems, leading to reconstruction artefacts. The algorithm uses multiple (5+) tracked fiducial beads to recover the sample pose and the image rays are then back-projected at each orientation. The quality of the image reconstruction using the proposed algorithm shows an improvement when compared to the Radon transform. Moreover, when adding a systematic spatial and angular mechanical drift, the reconstruction shows a significant improvement over the Radon transform.
Green tea extracts containing epigallocatechin-3-gallate modulate facial development in Down syndrome
Authors: Starbuck John M. , Llambrich Sergi , Gonzàlez Rubèn , Albaigès Julia , Sarlé Anna , Wouters Jens , González Alejandro , Sevillano Xavier , Sharpe James , De La Torre Rafael , Dierssen Mara , Vande Velde Greetje , Martínez-Abadías Neus 
Published: February 2021

AbstractTrisomy of human chromosome 21 (Down syndrome, DS) alters development of multiple organ systems, including the face and underlying skeleton. Besides causing stigmata, these facial dysmorphologies can impair vital functions such as hearing, breathing, mastication, and health. To investigate the therapeutic potential of green tea extracts containing epigallocatechin-3-gallate (GTE-EGCG) for alleviating facial dysmorphologies associated with DS, we performed an experimental study with continued pre- and postnatal treatment with two doses of GTE-EGCG supplementation in a mouse model of DS, and an observational study of children with DS whose parents administered EGCG as a green tea supplement. We evaluated the effect of high (100 mg/kg/day) or low doses (30 mg/kg/day) of GTE-EGCG, administered from embryonic day 9 to post-natal day 29, on the facial skeletal development in the Ts65Dn mouse model. In a cross-sectional observational study, we assessed the facial shape in DS and evaluated the effects of self-medication with green tea extracts in children from 0 to 18 years old. The main outcomes are 3D quantitative morphometric measures of the face, acquired either with micro-computed tomography (animal study) or photogrammetry (human study). The lowest experimentally tested GTE-EGCG dose improved the facial skeleton morphology in a mouse model of DS. In humans, GTE-EGCG supplementation was associated with reduced facial dysmorphology in children with DS when treatment was administered during the first 3 years of life. However, higher GTE-EGCG dosing disrupted normal development and increased facial dysmorphology in both trisomic and euploid mice. We conclude that GTE-EGCG modulates facial development with dose-dependent effects. Considering the potentially detrimental effects observed in mice, the therapeutic relevance of controlled GTE-EGCG administration towards reducing facial dysmorphology in young children with Down syndrome has yet to be confirmed by clinical studies.
Identification of distinct immune landscapes using an automated nine-color multiplex immunofluorescence staining panel and image analysis in paraffin tumor tissues
Authors: Parra Edwin R. , Zhai Jie , Tamegnon Auriole , Zhou Nicolas , Pandurengan Renganayaki Krishna , Barreto Carmelia , Jiang Mei , Rice David C. , Creasy Caitlin , Vaporciyan Ara A. , Hofstetter Wayne L. , Tsao Anne S. , Wistuba Ignacio I. , Sepesi Boris , Haymaker Cara 
Published: February 2021

AbstractImmune profiling is becoming a vital tool for identifying predictive and prognostic markers for translational studies. The study of the tumor microenvironment (TME) in paraffin tumor tissues such as malignant pleural mesothelioma (MPM) could yield insights to actionable targets to improve patient outcome. Here, we optimized and tested a new immune-profiling method to characterize immune cell phenotypes in paraffin tissues and explore the co-localization and spatial distribution between the immune cells within the TME and the stromal or tumor compartments. Tonsil tissues and tissue microarray (TMA) were used to optimize an automated nine-color multiplex immunofluorescence (mIF) panel to study the TME using eight antibodies: PD-L1, PD-1, CD3, CD8, Foxp3, CD68, KI67, and pancytokeratin. To explore the potential role of the cells into the TME with this mIF panel we applied this panel in twelve MPM cases to assess the multiple cell phenotypes obtained from the image analysis and well as their spatial distribution in this cohort. We successful optimized and applied an automated nine-color mIF panel to explore a small set of MPM cases. Image analysis showed a high degree of cell phenotype diversity with immunosuppression patterns in the TME of the MPM cases. Mapping the geographic cell phenotype distribution in the TME, we were able to identify two distinct, complex immune landscapes characterized by specific patterns of cellular distribution as well as cell phenotype interactions with malignant cells. Successful we showed the optimization and reproducibility of our mIF panel and their incorporation for comprehensive TME immune profiling into translational studies that could refine our ability to correlate immunologic phenotypes with specific patterns of cells distribution and distance analysis. Overall, this will improve our ability to understand the behavior of cells within the TME and predict new treatment strategies to improve patient outcome.