bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults
Authors: Rodrigues Wellington F. , Miguel Camila B. , Agostinho Ferdinando , da Silva Gabriela V. , Lazo-Chica Javier E. , Naressi Scapin Sandra M. , Napimoga Marcelo H. , Trindade-da-Silva Carlos A. , Krieger José E. , Pereira Alexandre da Costa , Oliveira Carlo J. Freire , Soares Siomar de Castro , Ueira-Vieira Carlos 
Published: November 2021

Periodontal disease is an infectious inflammatory disease related to the destruction of supporting tissues of the teeth, leading to a functional loss of the teeth. Inflammatory molecules present in the exudate are catalyzed and form different metabolites that can be identified and quantified. Thus, we evaluated the inflammatory exudate present in crevicular fluid to identify metabolic biological markers for diagnosing chronic periodontal disease in older adults. Research participants were selected from long-term institutions in Brazil. Participants were individuals aged 65 years or older, healthy, or with chronic periodontal disease. Gas chromatography/mass spectrometry was used to evaluate potential biomarkers in 120 crevicular fluid samples. We identified 969 metabolites in the individuals. Of these, 15 metabolites showed a variable importance with

projection

score
>
1

and were associated with periodontal disease. Further analysis showed that among the 15 metabolites, two (5-aminovaleric acid and serine, 3TMS derivative) were found at higher concentrations in the crevicular fluid, indicating their potential diagnostic power for periodontal disease in older adults. Our findings indicated that some metabolites are present at high concentrations in the crevicular fluid in older adults with periodontal disease and can be used as biomarkers of periodontal disease.
Enhanced Expression and Function of Renal SGLT2 (Sodium-Glucose Cotransporter 2) in Heart Failure: Role of Renal Nerves
Authors: Katsurada Kenichi , Nandi Shyam S. , Sharma Neeru M. , Patel Kaushik P. 
Published: November 2021

Background:
Recent clinical studies demonstrate that SGLT2 (sodium-glucose cotransporter 2) inhibitors ameliorate heart failure (HF). The present study was conducted to assess the expression and function of renal SGLT2 and the influence of enhanced renal sympathetic tone in HF.

Methods:
Four weeks after coronary artery ligation surgery to induce HF, surgical bilateral renal denervation (RDN) was performed in rats. Four groups of rats (Sham-operated control [Sham], Sham+RDN, HF and HF+RDN; n=6/group) were used. Immunohistochemistry and Western blot analysis were performed to evaluate the renal SGLT2 expression. One week after RDN (5 weeks after induction of HF), intravenous injection of SGLT2 inhibitor dapagliflozin were performed to assess renal excretory responses. In vitro, human embryonic kidney cells were used to investigate the fractionation of SGLT2 after norepinephrine treatment.

Results:
In rats with HF, (1) SGLT2 expression in the proximal tubule of the kidney was increased; (2) the response of increases in urine flow, sodium excretion, and glucose excretion to dapagliflozin were greater; and (3) RDN attenuated renal SGLT2 expression and normalized renal functional responses to dapagliflozin. In vitro, norepinephrine promoted translocation of SGLT2 to the cell membrane.

Conclusions:
These results indicate that the enhanced tonic renal sympathetic nerve activation in HF increases the expression and functional activity of renal SGLT2. Potentiated trafficking of SGLT2 to cell surface in renal proximal tubules mediated by norepinephrine may contribute to this functional activation of SGLT2 in HF. These findings provide critical insight into the underlying mechanisms for the beneficial effects of SGLT2 inhibitors on HF reported in the clinical studies.
Effect of Deferoxamine on Outcome According to Baseline Hematoma Volume: A Post Hoc Analysis of the i-DEF Trial
Authors: Wei Chenchen , Wang Jeffrey , Foster Lydia D. , Yeatts Sharon D. , Moy Claudia , Mocco J , Selim Magdy , Palesch Yuko , Griffin Jessica , Perlmutter Aaron , Norton Casey , Dillon Catherine , Thornhill Andre , Greenberg Steven , Morgenstern Lewis , Hanley Daniel , Xi Guohua , Bleck Thomas P , Balk Robert , Palesch Yuko , Griffin Jessica , Thornhill Andre , Perlmutter Aaron , Dillon Catherine , Zhao Wenle , Kim Jaemyung , Kumar Sandeep , Norton Casey , Farinella Megan , Siwila-Sackman Erica , Feigert Caroline , Schlaug Gottfried , Wang Jasmine , Wright Clinton , Janis Scott , Gilbert Peter , Kase Carlos S , Carson Shannon , Flaherty Matthew , Kessler Craig M , McClure Leslie A , Bannon Donna , Broderick Joseph , Dill Amy 
Published: November 2021

Background:
Hematoma volume (HV) is a powerful determinant of outcome after intracerebral hemorrhage. We examined whether the effect of the iron chelator, deferoxamine, on functional outcome varied depending on HV in the i-DEF trial (Intracerebral Hemorrhage Deferoxamine).

Methods:
A post hoc analysis of the i-DEF trial; participants were classified according to baseline HV (small <10 mL, moderate 10–30 mL, and large >30 mL). Favorable outcome was defined as a modified Rankin Scale score of 0–2 at day-180; secondarily at day-90. Logistic regression was used to evaluate the differential treatment effect according to HV.

Results:

Two hundred ninety-one subjects were included in the as-treated analysis; 121 with small, 114 moderate, and 56 large HV. Day-180 modified Rankin Scale scores were available for 270/291 subjects (111 with small, 105 moderate, and 54 large HV). There was a differential effect of treatment according to HV on day-180 outcomes (
P
-for-interaction =0.0077); 50% (27/54) of deferoxamine-treated patients with moderate HV had favorable outcome compared with 25.5% (13/51) of placebo-treated subjects (adjusted odds ratio, 2.7 [95% CI, 1.13–6.27];
P
=0.0258). Treatment effect was not significant for small (adjusted odds ratio, 1.37 [95% CI, 0.62–3.02]) or large (adjusted odds ratio, 0.12 [95% CI, 0.01–1.05]) HV. Results for day-90 outcomes were comparable (
P
-for-interaction =0.0617). Sensitivity analyses yielded similar results.

Conclusions:
Among patients with moderate HV, a greater proportion of deferoxamine- than placebo-treated patients achieved modified Rankin Scale score 0–2. The treatment effect was not significant for small or large HVs. These findings have important trial design and therapeutic implications.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02175225.
The Populist Revolt against the West
Authors: Schroeder Ralph 
Published: November 2021

Abstract
The question this article tries to answer is: to what extent can the recent rise of populism outside of the West be attributed to anti-Western sentiment? Interest in populism has focused on Western democracies, with far less attention devoted to regimes in non-Western parts of the world. This article takes three major cases – India, China, and Turkey. The article examines the recent intensification of populism in the three cases, but also shows how populism fits into the longer comparative-historical trajectories of a revolt against Western domination. The conclusion puts populism in a wider perspective: how do these non-Western assertions of populism shed light on debates about alternative paths within modernity and on the nature of populism in Western democracies?
Mental health and wellbeing of Indonesian medical students: A regional comparison study
Authors: Kloping Nabila Ananda , Citraningtyas Theresia , Lili Rossalina , Farrell Sarah Marie , Molodynski Andrew 
Published: November 2021

Background: Our previous research found very high levels of burnout and mental health problems among medical students across Indonesia, in line with rates in many other countries. This study further analyses the data by comparing six different regions of Indonesia to determine any differences between them on such measures and to look for possible explanations. Results: Our sample of 1,729 students reported high levels of burnout and ‘mild’ psychiatric illness across all six regions. There were however significant differences between some regions. Sumatran students reported the lowest scores for both the Oldenburg Burnout Inventory (OLBI) and General Health Questionnaire 12 (GHQ12) scales. Sources of stress also varied among regions, with relationships and study the most reported. Further exploration of possible cultural differences is needed as well as prompt mental health support for medical students.
Diverse neighbors and post-conflict recovery at the village level: Evidence from Iraq after ISIL
Authors: Lyall Lloyd 
Published: November 2021

Why do some towns recover faster than others after intrastate conflict? Many important decisions about post-conflict recovery are made at the substate level, but little empirical work has investigated what causes differences in recovery outcomes within a country. This article suggests that proximity to ethno-religiously diverse neighbors slows a town’s post-conflict recovery. A town has ‘diverse neighbors’ if towns with different plurality ethno-religious groups are nearby. This hypothesis is tested by exploring variation in recovery speed among Iraqi towns after the 2014–17 Islamic State insurgency (ISIL). The article constructs 81-month panels of economic activity for 379 Iraqi settlements occupied by ISIL by using satellite-observed nighttime light emissions as a proxy for economic activity. The panels reveal large variation in post-conflict recovery among towns during the first year of peace. Village-level survey data are then used to construct a measure of neighbor diversity, which is combined with lighting-based recovery scores in spatial autoregression. The results show that greater neighbor diversity is robustly associated with slower settlement recovery. The neighbor diversity penalty cannot be fully explained by cleavages between groups ‘on opposite sides’ of the conflict; proximity to out-group neighbors appears to slow recovery even between wartime allies. Several explanations are considered, and this article suggests that the types of post-liberation controllers that arise in diverse areas – which tend to be substate militias rather than the government – may be one important mechanism.
Price versus clinical guidelines in primary care statin prescribing: a retrospective cohort study and cost simulation model
Authors: De Zarate Matias Ortiz , Mentzakis Emmanouil , Fraser Simon DS , Roderick Paul , Rutter Paul , Ornaghi Carmine 
Published: November 2021

Objective To investigate the relative impact of generic entry and National Institute for Health and Care Excellence clinical guidelines on prescribing using statins as an exemplar. Design Retrospective analysis of statin prescribing in primary care and cost simulation model. Setting Royal College of General Practitioners Research and Surveillance Centre (RCGP R&SC) database and Prescription Cost Analysis (PCA) database. Participants New patients prescribed statins for the first time between July 2003 and September 2018. Main outcome measures Shares of new patients prescribed one of the five statins available in the British National Formulary, and cost of prescribing statins to new and existing patients in primary care in England. Results General trends of statin’ prescriptions were largely driven by a decrease in acquisition costs triggered by patent expiration, preceding NICE guidelines which themselves did not seem to affect prescription trends. Significant heterogeneity is observed in the prescription of the most cost-effective statin acrossGPs. A cost simulation shows that, between 2004 and 2018, the NHS could have saved £2.8bn (around 40% of the £6.3bn spent on statins during this time) if all GP practices had prescribed only the most cost-effective treatment. Conclusions There is potential for large savings for the NHS if new and, whenever possible, ongoing patients are promptly switched to the first medicine that becomes available as generic within a therapeutic class as long as it has similar efficacy to still-patented medicines.
Investigation of the anti-inflammatory effects of caffeic acid phenethyl ester in a model of λ-Carrageenan–induced paw edema in rats
Authors: Semis Halil Sezgin , Gur Cihan , Ileriturk Mustafa , Kaynar Ozgur , Kandemir Fatih Mehmet 
Published: November 2021

In the present study, it is aimed to evaluate the effects of caffeic acid phenethyl ester (CAPE) against acute paw inflammation induced by carragenan (Carr) at macro and micro levels. Therefore, in this study, 1 hour after administering intraperitoneal of indomethacin (Ind) or CAPE (10 and 30 mg/kg body weight) to Sprague Dawley rats, Carr was injected intraplantarly into their right paws. The paw volumes of the rats were measured with a plethysmometer until the 4th hour. Also, X-ray and thermal camera images were taken to determine edema and temperature changes. At the end of the study, after the paw tissues and serums were taken, oxidative stress and inflammation status were determined using biochemical, molecular, and western blot techniques. In addition, lipid and protein profiles in paw tissue were determined using HPTLC and electrophoresis methods. The results depicted that a high dose of CAPE against Carr-induced inflammation may be almost as effective as Ind used as reference.
Patients’ knowledge and awareness of safe handling of oral anticancer agents at Sultan Qaboos University Hospital in Oman
Authors: Hassan Moataz M , Al-Marzooq Dhabya , Al-Habsi Hanan , Al-Hashar Amna , Al-Khabori Murtadha , Al-Moundhri Mansour , Al-Zakwani Ibrahim 
Published: November 2021

Background Safe handling of oral anticancer agents is of great concern. There is a lack of clear, national guidelines on how patients can safely handle and dispose of unwanted medications. We aimed to evaluate the safe handling, storage, and disposal of oral anticancer drugs among cancer patients and caregivers at home. Method This cross-sectional survey of adult cancer patients (or their adult caregivers) used a closed-ended questionnaire from May 2019 to March 2020. Results A total of 257 patients (50 ± 15 years; range: 18–93 years) were enrolled; however, only 91% (233/257) reported self-administering oral anticancer medications. Caregivers were more likely to administer oral anticancer agents for patients ≥60 years than those <40 years old (63% vs. 8%; P = 0.001). Most patients (52%; 133/257) did not wash their hands after administering the drug; 74% (164/222) of the respondents reported that their medications were kept in a bedroom cabinet, while 18% (40/222) stored their medications in a refrigerator, and 5% (12/222) in a kitchen cabinet. A total of 55% (68/124) of patients returned their excess oral chemotherapy medications to the hospitals; however, 36% (45/124) disposed of their unused oral chemotherapy drugs in a household garbage container. Conclusion While two-thirds of patients stored their oral anticancer medications properly, more than half used inappropriate handling procedures. Disposal practices were inconsistent and did not adhere to the reported international guidelines.
Diabetic ketoacidosis as a hallmark of autoimmune diabetes occurring after two cycles of cemiplimab
Authors: Jouneghani Nasrin Saleh , Phillip John , Dasanu Constantin A 
Published: November 2021

Introduction Clinical indications of immune checkpoint inhibitors have expanded to a variety of malignancies. Nearly 50% of patients with advanced cutaneous squamous cell carcinoma, respond to the programmed-death 1 inhibitor cemiplimab. To date, insulin-dependent diabetes mellitus has been documented with the use of several immune checkpoint inhibitors but not cemiplimab. Case report We report herein the first case of a patient with cutaneous squamous cell carcinoma who developed diabetic ketoacidosis and insulin-dependent diabetes mellitus following only two cycles of cemiplimab. A score of 6 on the Naranjo nomogram makes the causality relationship between cemiplimab use and the insulin-dependent diabetes mellitus probable. Management and outcome The patient's developed diabetic ketoacidosis was managed with intravenous fluids and intravenous insulin, with a prompt resolution. Cemiplimab was discontinued, and the patient was discharged on long-acting and short-acting insulin therapy, with a follow-up with endocrinology. Discussion/conclusions The mechanism by which cemiplimab caused insulin-dependent diabetes mellitus is most likely due to lack of endogenous insulin production in the setting of immune-mediated loss of pancreatic beta-cells. Patients may benefit from fasting blood glucose monitoring and early immune checkpoint inhibitor discontinuation where elevated serum glucose is detected.
Sunitinib induced colitis manifesting as invasive diarrhea in a patient with renal cell carcinoma
Authors: Gündoğdu Yasemin , Deniz Orhan Cem , Saka Didem , Şişman Gürhan , Erdamar Sibel , Köksal İftihar 
Published: November 2021

Introduction Sunitinib is a tyrosine kinase inhibitor that binds to vascular endothelial factor receptor currently used for the treatment of renal cell carcinoma, as well as for several other conditions such as gastrointestinal stromal tumors and pancreatic neuroendocrine tumors. We present a patient with invasive diarrhea who was treated with sunitinib for metastatic renal cell carcinoma. Case report Drug induced colitis was confirmed with colonoscopy from histopathological specimens. Clinical recovery of diarrhea was achieved with oral budesonide. Remarkably, the pathologic findings were observed in both the macroscopically normal mucosa and the mucosa with aphthous ulcers in the colon. Management & outcome The patient was treated for sunitinib associated diarrhea, after exclusion of the other reasons. Metronidazole and piperacillin/tazobactam treatment were prescribed. Discussion Diarrhea is a frequent symptom in patients treated with tyrosine kinase inhibitors, however the described pathologic findings have rarely been reported. Our aim is to emphasize the importance of close follow-up in patients treated with tyrosine kinase inhibitors, and to raise awareness on the management of sunitinib induced colitis.
The FACT : Use of a novel intermittent pneumatic compression device to promote pre-surgery arm vein dilation in patients with chronic renal failure
Authors: Hammes Mary , Desai Sanjay , Lucas John F , Mitta Nivedita , Pulla Abhishek , Mitra Amit 
Published: November 2021

Background: Arteriovenous fistula (AVF) creation and maturation for hemodialysis is globally a topic of importance given the poor results and high costs associated with renal care. Successful AVF (surgical or endovascular) creation requires appropriate superficial veins and quality arteries. Many procedures fail due to initial small veins with limited blood flow capacity and distensibility. Intermittent pneumatic compression has previously shown success in trials to increase superficial veins in patients with end stage renal disease post AVF. The objective of this study is to investigate the role of an intermittent pneumatic device, the Fist Assist®, to dilate cephalic arm veins in patients with advanced chronic kidney disease (CKD) prior to AVF placement. Methods: Three centers enrolled subjects from June 2019 through July 2021. Baseline Doppler measurements of the cephalic vein in standard locations the forearm and upper arm with and without a blood pressure cuff were recorded. Patients were instructed and used Fist Assist® on their non-dominant arm for up to 4 h daily for 90 days. At approximately 3 months, Doppler measurements were repeated. The primary endpoint was cephalic vein enlargement with secondary endpoints based on percentage of veins approaching 2.5 mm in the forearm and 3.5 mm in the upper arm. Results: Thirty-seven subjects with CKD (mean eGFR 13.8 mL/min) were enrolled and completed the trial. Paired-difference t-tests (one tail) for aggregate data showed significant venous dilation of the cephalic vein in both the forearm and upper arm after use with the Fist Assist® ( p < 0.05). Mean differences in the forearm veins were approximately 0.6 and 1.1 mm in the upper arm cephalic vein after Fist Assist® application. There were no major complications reported by any subject during the trial. Conclusions: Fist Assist® use in patients with CKD is effective to enhance vein dilation. Forearm and upper arm cephalic veins increased on average 0.6 and 1.1 mm respectively after Fist Assist® application. This is the first trial to evaluate the effect of intermittent, focal pneumatic compression on pre-surgery vein diameter in patients with advanced CKD before AVF creation.
Defining difficult intravenous access (DIVA): A systematic review
Authors: Bahl Amit , Johnson Steven , Alsbrooks Kimberly , Mares Alicia , Gala Smeet , Hoerauf Klaus 
Published: November 2021

Background: The term “difficult intravenous access” (DIVA) is commonly used but not clearly defined. Repeated attempts at peripheral intravenous catheter (PIVC) insertion can be a traumatic experience for patients, leading to sub-optimal clinical and economic outcomes. We conducted a systematic literature review (SLR) to collate literature definitions of DIVA, with the aim of arriving at an evidence-driven definition. Methods: The SLR was designed to identify clinical, cost, and quality of life publications in patients requiring the insertion of a PIVC in any setting, including studies on US-guidance and/or guidewire, and studies with no specific intervention. The search was restricted to English language studies published between 1st January 2010 and 30th July 2020, and the Ovid platform was used to search several electronic databases, in addition to hand searching of clinical trial registries. Results: About 121 studies were included in the SLR, of which 64 reported on the objectives relevant to this manuscript. Prevalence estimates varied widely from 6% to 87.7% across 19 publications, reflecting differences in definitions used. Of 43 publications which provided a definition of DIVA, six key themes emerged. Of these, themes 1–3 (failed attempts at PIV access using traditional technique; based on physical examination findings for example no visible or palpable veins; and personal history of DIVA) were covered by all but one publication. Following a failed insertion attempt, the most common number of subsequent attempts was 3, and it was frequently reported that a more experienced clinician would attempt to gain access after multiple failed attempts. Conclusions: Considering the themes identified, an evidence-driven definition of DIVA is proposed: “when a clinician has two or more failed attempts at PIV access using traditional techniques, physical examination findings are suggestive of DIVA (e.g. no visible or palpable veins) or the patient has a stated or documented history of DIVA.”