bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergency surgery for hemobilia due to hepatic artery pseudoaneurysm rupture complicated by Mirizzi syndrome type II: a case report
Authors: Shishido Yutaka , Fujimoto Koji , Yano Yasumichi , Mitsuoka Eisei , Komatsubara Takashi , Shio Seiji , Ishii Masayuki , Higashiyama Hiroshi 
Published: August 2021

Abstract
Background
Hemobilia refers to bleeding into the biliary tract. Hepatic artery pseudoaneurysm (HAP) rupture is an uncommon cause of hemobilia, and cases of HAP associated with Mirizzi syndrome are extremely rare. Although transarterial embolization is recommended as the first-line treatment for hemobilia, surgery is sometimes required.

Case presentation
A 76-year-old woman was referred to our hospital with epigastric pain. She was febrile and had conjunctival icterus and epigastric tenderness. Laboratory tests revealed abnormal white blood cell count and liver function. An abdominal computed tomography (CT) revealed multiple calculi in the gallbladder, an incarcerated calculus in the cystic duct, and a slightly dilated common hepatic duct. Based on examination findings, she was diagnosed with Mirizzi syndrome type I, complicated by cholangitis. Intravenous antibiotics were administered, and we performed endoscopic retrograde cholangiopancreatography (ERCP) to place a drainage tube. The fever persisted; therefore, contrast-enhanced CT (CECT) was performed. This revealed portal vein thrombosis and hepatic abscesses; therefore, heparin infusion was administered. The following day, she complained of melena, and laboratory tests showed that she was anemic. ERCP was performed to change the drainage tube in the bile duct; however, bleeding from the papilla of Vater was observed. CECT demonstrated a right HAP with high-density fluid in the gallbladder and gallbladder perforation. Finally, she was diagnosed with hemobilia caused by HAP rupture, and emergency surgery was performed to secure hemostasis and control the infection. During laparotomy, we found that a right HAP had ruptured into the gallbladder. The gallbladder made a cholecystobiliary fistula, which indicated Mirizzi syndrome type II. Although we tried to repair the right hepatic artery, we later ligated it due to arterial wall vulnerability. Then, we performed subtotal cholecystectomy and inserted a T-tube into the common bile duct. There were no postoperative complications except for minor leakage from the T-tube insertion site. The patient was discharged after a total hospital stay of 7 weeks.

Conclusions
We experienced an extremely rare case of emergency definitive surgery for hemobilia due to HAP rupture complicated by Mirizzi syndrome type II. Surgery might be indicated when controlling underlying infections was required.
Origin of MMP-8 and Lactoferrin levels from gingival crevicular fluid, salivary glands and whole saliva
Authors: Ramenzoni Liza L. , Hofer Deborah , Solderer Alex , Wiedemeier Daniel , Attin Thomas , Schmidlin Patrick R. 
Published: August 2021

Abstract
Background
Pathologically elevated levels of matrix metalloproteinase-8 (MMP-8) and Lactoferrin in oral fluids have been associated with the presence of gingivitis/periodontitis. This study aimed to assess the origin of MMP-8 and Lactoferrin in periodontitis patients and to identify the degree to which conventional clinical parameters correlate with their presence.

Methods
A total of ten periodontitis and ten healthy patients were included in this study. Whole saliva (stimulated and unstimulated), parotid/sublingual glandular fluid and gingival crevicular fluid from pockets and sulci were tested for MMP-8 and Lactoferrin and protein concentrations were quantified using an ELISA assay. Clinical parameters were checked for potential associations with MMP-8 and Lactoferrin levels.

Results
Periodontal patients presented higher concentrations of MMP-8 and Lactoferrin in pockets than other sources (P = 0.03). Lactoferrin measurement was higher in the parotid compared to sublingual glandular fluid in periodontitis patients (P = 0.03). Increased probing pocket depth was positively correlated with high MMP-8 and Lactoferrin levels.

Conclusions
Periodontal pockets appear to be the major source of active matrix metalloproteinase and Lactoferrin, which also may also enter the oral cavity through the salivary glands. Since clinically healthy sites in periodontitis patients also had elevated biomarker levels, gingival crevicular fluid biomarker testing may be more predictive of future tissue breakdown than conventional clinical parameters.
Pregnant women utilization of dental services: still a challenge in low resource setting
Authors: Onwuka Chidozie , Onwuka Chidinma Ifechi , Iloghalu Emeka Ifeanyi , Udealor Peter Chukwudi , Ezugwu Euzebus Chinonye , Menuba Ifeanyi Emmanuel , Ugwu Emmanuel Onyebuchi , Ututu Chinyere 
Published: August 2021

Abstract
Background
Poor oral health in pregnancy can be associated with poor pregnancy outcome, however, dental consultation among pregnant women appears to be low.

Methods
This was a questionnaire-based study of 413 women who attended the antenatal clinic of University of Nigeria Teaching Hospital (UNTH), Ituku/Ozalla, Enugu. The information obtained was analyzed using SPSS version 22. A p-value of less than 0.05 was considered statistically significant.

Results
Only 36 (8.7%) of the respondents had dental consultations in index pregnancy for complaints such as tooth ache and decay (66.7%) and pain as well as swelling of the gum (33.3%). The most common reason given for not visiting a dentist during the index pregnancy was the visit not being relevant to their pregnancy outcome (69.2%). After counseling them, only 249 (60.3%) agreed to have dental consultation during subsequent pregnancies. The relationship between visiting the dentist and place of residence (< 0.001), occupation (0.019) and frequency of brushing/ changing of brush (0.005, < 0.001 respectively) were statistically significant.

Conclusion
The prevalence of dental consultation during pregnancy is very low. Pregnant women should be encouraged to have routine dental consultation with oral health counseling and check-up incorporated as part of routine antenatal care.
Bayesian semi-parametric spatial modelling of intimate partner violence in Namibia using 2013 Demographic Health Survey Data
Authors: Ojifinni Oludoyinmola , Maposa Innocent , Ibisomi Latifat 
Published: August 2021

Abstract
Background
Intimate partner violence (IPV) is an important public health problem with health and socioeconomic consequences and is endemic in Namibia. Studies assessing risk factors for IPV often use logistic and Poisson regression without geographical location information and spatial effects. We used a Bayesian spatial semi-parametric regression model to determine the risk factors for IPV in Namibia; assess the non-linear effects of age difference between partners and determine spatial effects in the different regions on IPV prevalence.

Methods
We used the couples’ dataset of the 2013–2014 Namibia Demographic and Health Survey (DHS) obtained on request from Measure DHS. The DHS domestic violence module included 2226 women. We generated a binary variable measuring IPV from the questions “ever experienced physical, sexual or emotional violence?” Covariates included respondent’s educational level, age, couples’ age difference, place of residence and partner’s educational level. All estimation was done with the full Bayesian approach using R version 3.5.2 implementing the R2BayesX package.

Results
IPV country prevalence was 33.3% (95% CI = 30.1–36.5%); Kavango had the highest [50.6% (95% CI = 41.2–60.1%)] and Oshana the lowest [11.5% (95% CI = 3.2–19.9%)] regional prevalence. IPV prevalence was highest among teenagers [60.8% (95% CI = 36.9–84.7%)]). The spatial semi-parametric model used for adjusted results controlled for regional spatial effects, respondent’s age, age difference, respondent’s years of education, residence, wealth, and education levels. Women with higher education were 50% less likely to experience IPV [aOR: 0.46, 95% CI = 0.23–0.87]. For non-linear effects, the risk of IPV was high for women ≥ 5 years older or ≥ 25 years younger than their partners. Younger and older women had higher risks of IPV than those between 25 and 45 years. For spatial variation of IPV prevalence, northern regions had low spatial effects while western regions had very high spatial effects.

Conclusion
The prevalence of IPV among Namibia women was high especially among teenagers, with higher educational levels being protective. The risk of IPV was lower in rural than urban areas and higher with wide partner age differences. Interventions and policies for IPV prevention in Namibia are needed for couples with wide age differences as well as for younger women, women with lower educational attainment and in urban and western regions.
Breathing variability—implications for anaesthesiology and intensive care
Authors: van den Bosch Oscar F. C. , Alvarez-Jimenez Ricardo , de Grooth Harm-Jan , Girbes Armand R. J. , Loer Stephan A. 
Published: August 2021

AbstractThe respiratory system reacts instantaneously to intrinsic and extrinsic inputs. This adaptability results in significant fluctuations in breathing parameters, such as respiratory rate, tidal volume, and inspiratory flow profiles. Breathing variability is influenced by several conditions, including sleep, various pulmonary diseases, hypoxia, and anxiety disorders. Recent studies have suggested that weaning failure during mechanical ventilation may be predicted by low respiratory variability. This review describes methods for quantifying breathing variability, summarises the conditions and comorbidities that affect breathing variability, and discusses the potential implications of breathing variability for anaesthesia and intensive care.
Assessment of CareStart G6PD rapid diagnostic test and CareStart G6PD biosensor in Mauritania
Authors: Djigo Oum Kelthoum Mamadou , Ould Khalef Yacoub , Ould Ahmedou Salem Mohamed Salem , Gomez Nicolas , Basco Leonardo , Briolant Sébastien , Ould Mohamed Salem Boukhary Ali 
Published: August 2021

Abstract
Background
The elimination of Plasmodium vivax malaria requires 8-aminoquinolines, which are contraindicated in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency due to the risk of acute haemolytic anaemia. Several point-of-care devices have been developed to detect G6PD deficiency. The objective of the present study was to evaluate the performance of two of these devices against G6PD genotypes in Mauritania.

Methods
Outpatients were screened for G6PD deficiency using CareStart™ rapid diagnostic test (RDT) and CareStart™ G6PD biosensor in Nouakchott, Mauritania, in 2019–2020. African-type and Mediterranean-type G6PD genotypes commonly observed in Africa were determined by polymerase chain reaction-restriction fragment length polymorphism and sequencing. Qualitative variables were compared using Fisher’s exact test.

Results
Of 323 patients (74 males and 249 females), 5 males and 2 homozygous females had the African-type A- genotype: A−(202) in 3 males and 2 females and G6PD A−(968) in 2 males. Among heterozygous females, 13 carried G6PD A−(202), 12 G6PD A−(968), and 3 G6PD A−(542) variants. None had the Mediterranean-type G6PD genotype. Eight had a positive G6PD RDT result, including all 7 hemizygous males and homozygous females with A- or A-A- (0.12 to 2.34 IU/g haemoglobin, according to G6PD biosensor), but RDT performed poorly (sensitivity, 11.1% at the cut-off level of < 30%) and yielded many false negative tests. Thirty-seven (50.0%) males and 141 (56.6%) females were anaemic. The adjusted median values of G6PD activity were 5.72 and 5.34 IU/g haemoglobin in non-anaemic males (n = 35) and non-anaemic males and females (n = 130) with normal G6PD genotypes using G6PD biosensor, respectively. Based on the adjusted median of 5.34 IU/g haemoglobin, the performance of G6PD biosensor against genotyping was as follows: at 30% cut-off, the sensitivity and specificity were 85.7% and 91.7%, respectively, and at 80% cut-off, the sensitivity was 100% while the specificity was 64.9%.

Conclusions
Although this pilot study supports the utility of biosensor to screen for G6PD deficiency in patients, further investigation in parallel with spectrophotometry is required to promote and validate a more extensive use of this point-of-care device in areas where P. vivax is highly prevalent in Mauritania.

Graphic abstract
TERT Promoter Mutations Are Enriched in Oral Cavity Cancers and Associated With Locoregional Recurrence
Authors: Yu Yao , Fan Dan , Song Xinmao , Zakeri Kaveh , Chen Linda , Kang Jung , McBride Sean , Tsai C. Jillian , Dunn Lara , Sherman Eric , Katabi Nora , Dogan Snjezana , Cracchiolo Jennifer , Cohen Marc , Boyle Jay O. , Lee Mark , Valero Cristina , Wang Jingming , Wong Richard , Morris Luc , Riaz Nadeem , Lee Nancy 
Published: August 2021

PURPOSE Telomerase reverse transcriptase ( TERT) promoter mutations are prognostic in many cancers and have been observed in human papillomavirus (HPV)–negative head and neck squamous cell carcinomas (HNSCCs). However, the role of TERT promoter mutations in HPV-negative HNSCCs remains poorly understood in these cancers, which have increased risk for locoregional failure (LRF). PATIENTS AND METHODS We retrospectively identified patients who were diagnosed with HNSCC between July 1, 2004, and October 12, 2017, at Memorial Sloan Kettering Cancer Center and whose tumors underwent next-generation sequencing using the MSK-IMPACT panel. Patients with HPV-positive oropharyngeal squamous cell carcinoma (SCC) were excluded. Cumulative incidence of LRF, patterns of failure, and overall survival were measured. RESULTS We identified 117 patients with SCC of the oral cavity (OSCC), larynx, hypopharynx, or HPV-negative oropharynx whose tumors underwent next-generation sequencing. Sequencing was performed on 95 tumors that were obtained after recurrence and 22 that were obtained before recurrence. TERT promoter mutations were enriched in OSCC compared with laryngopharyngeal cancers (81.1% v 7.0%; P < .001), which was the largest genetic difference between these anatomic disease subsites. TERT promoter mutations were associated with LRF in OSCCs (Gray's test, P < .001) and in the overall cohort (Gray's test, P < .001). On multivariate analysis, TERT promoter mutations were associated with an increased risk for LRF (subdistribution hazard ratio, 2.82; 95% CI, 1.47 to 5.42; P = .0019), independent of oral cavity primary site and TP53 mutation status. CONCLUSION TERT promoter status is associated with the cumulative incidence of LRF and patterns of failure. TERT promoter mutations may define a subset of OSCCs with unique pathogenesis that is associated with an increased risk of LRF. Validation in prospective cohorts is warranted.
QuantifyPolarity, a new tool-kit for measuring planar polarized protein distributions and cell properties in developing tissues
Authors: Tan Su Ee , Tan Weijie , Fisher Katherine H. , Strutt David 
Published: August 2021

ABSTRACT
The coordination of cells or structures within the plane of a tissue is known as planar polarization. It is often governed by the asymmetric distribution of planar polarity proteins within cells. A number of quantitative methods have been developed to provide a readout of planar polarized protein distributions. However, previous planar polarity quantification methods can be affected by variation in cell geometry. Hence, we developed a novel planar polarity quantification method based on Principal Component Analysis (PCA) that is shape insensitive. Here, we compare this method with other state-of-the-art methods on simulated models and biological datasets. We found that the PCA method performs robustly in quantifying planar polarity independently of variation in cell geometry and other image conditions. We designed a user-friendly graphical user interface called QuantifyPolarity, equipped with three polarity methods for automated quantification of polarity. QuantifyPolarity also provides tools to quantify cell morphology and packing geometry, allowing the relationship of these characteristics to planar polarization to be investigated. This tool enables experimentalists with no prior computational expertise to perform high-throughput cell polarity and shape analysis automatically and efficiently.
Archäologische Aufschlüsse zum ehemaligen Spital an der Freien Strasse
Authors: Matt Christoph Ph. 
Published: August 2021

Am Fusse des Münsterberges lag vom Mittelalter bis ins 19. Jahrhundert das bürgerliche Spital («Spital an den Schwellen»); ein grösserer, mehrteiliger Gebäudekomplex mit Innenhöfen und einer Spitalkirche, der auf älteren Plänen und Abbildungen verschiedentlich dargestellt ist.
Nebst zum Spital gehörender Mauern wurde eine vermutlich mittelalterliche Strassenpflästerung, ein Brunnensockel von 1837 und Reste der neuzeitlichen Überbauung dokumentiert.
Neue Erkenntnisse zur Befestigung der inneren St. Alban-Vorstadt
Authors: Helmig Guido 
Published: August 2021

Der Befestigung der inneren St. Alban-Vorstadt, d.h. des Abschnittes zwischen dem St. Alban-Graben und der Malzgasse, kommt hinsichtlich des Anschlusses des Klosterareales an die Inneren Mauern der Stadt Basel besondere Bedeutung zu.
Erst im späteren 13. Jahrhundert erfahren wir von einem Anschluss des eingezonten Klosterareales an die bestehende Innere Stadtbefestigung mittels einer zwischen der selbständigen «Klosterinsel» und der Inneren Stadtmauer am St. Alban-Graben inzwischen angelegten Befestigung. Der somit neu umschlossene Bereich bildete das Bindeglied zwischen der Bischofsstadt und dem engeren Klosterbezirk. Er wurde vorerst von einem unmittelbar südlich des Kunostores (St. Alban-Schwibbogen am Eingang der Rittergasse) an den Inneren Stadtgraben anschliessenden Graben gegen Süden abgeschlossen und reichte nach Osten bis zur heutigen Malzgasse.
Neue Befunde an der Malzgasse 2 haben uns bewogen, die bisher bekannten Fakten aufzugreifen.
Ein Stadtmauerbefund im Kleinen Klingental
Authors: Jaggi Bernard 
Published: August 2021

Im Rahmen der in den Jahren 1988 bis 1991 durchgeführten Sanierungsarbeiten am Kleinen Klingental ergab sich für die Basler Denkmalpflege die Möglichkeit, den Kern der Kleinbasler Klosterniederlassung, der in diese Gebäudegruppe eingebettet ist, baugeschichtlich zu erforschen.
Da die Ergebnisse der baugeschichtlichen Untersuchungen am Kleinen Klingental ausführlich publiziert werden, soll im folgenden nur kurz auf die Kleinbasler Stadtmauer, von der ein Teilstück freigelegt und nachgewiesen werden konnte, eingegangen werden. Der in die Nordfassade des kasernenseitigen Flügels des Kleinen Klingentals integrierte Stadtmauerabschnitt ist noch in der originalen Höhe erhalten.
Zum mutmasslichen Vorgängertor des St. Johanns-Tores
Authors: Helmig Guido 
Published: August 2021

Wir benützten die Gelegenheit, um an dieser Stelle nach weiteren Spuren der 1984 in unmittelbarer Nähe aufgedeckten Mauerzüge zu suchen, die mit einem mutmasslichen Vorgängertor des St. Johanns-Tores in Verbindung gebracht wordenwaren.
Die 1984 im Umkreis des Tores in den Leitungsgräben nur grob skizzierten Mauerbefunde liefern den Hinweis, dass der Anbau ursprünglich offenbar «teilunterkellert» war bzw. mit einer Wolfsgrube ausgestattet gewesen sein könnte; so oder so spricht ein «Untergeschoss» oder eine Unterkellerung in der Torgasse selbst gegen die Deutung des Bauwerkes als Torbau.
Fünf weitere Gräber des spätrömischen Friedhofs am Totentanz
Authors: Richner Kaspar , Tancik Viera 
Published: August 2021

Seit der Entdeckung von drei Gräbern im Jahre 1984, die dank ihrer Beigaben ins späte 3. und in die erste Hälfte des 4. Jahrhunderts n. Chr. datiert werden können, ist die Existenz eines spätrömischen Friedhofes am Totentanz gesichert.
Der spätrömische Friedhof am Totentanz hat sich seither auf total mindestens 11 Gräber vergrössert; 10 davon sind Körperbestattungen, eines eine Brandbestattung.
Der ehemalige Klingentalfriedhof
Authors: Richner Kaspar , Trancik Viera 
Published: August 2021

Neben dem Chor der Klingentalkirche befand sich der Friedhof des Klosters Klingental, der 1450 erwähnt wird. Nach der Reformation wurde er 1541 den Hintersassen (Nicht-Bürgern) und dem Dienstvolk von Kleinbasel zugewiesen. 1635 nahm der Friedhof Pesttote auf, später nur noch Ertrunkene. Seit 1779 wird er nicht mehr benutzt.
Die Tiefe der Baugrube von ca. 1 m reichte bereits aus, um 5 Gräber (eines davon eine Doppelbestattung) zu stören. Im Aushub konnten als Streufunde noch die Reste von mindestens 8 weiteren Individuen geborgen werden.
“Now or Later?” When to Deploy Qualification Screening in Open-Bid Auction for Re-Sourcing
Authors: Zhang Wen , Chen Qi (George) , Katok Elena 
Published: August 2021

Designing Open-bid Procurement Auction with Supplier Qualification Screenings Manufacturers often use re-sourcing initiatives to keep their suppliers’ pricing competitive; e.g., new entrant suppliers are identified and invited to compete with the incumbent supplier for supply contracts in an open-bid auction. To ensure that entrant suppliers have the capability of executing the contract, the conventional approach for many manufacturers is to conduct qualification screenings on all the entrants prior to auction bidding and only allow qualified entrant suppliers to compete in the auction. In “‘Now or Later?’ When to Deploy Qualification Screening in Open-Bid Auction for Re-Sourcing”, Zhang, Chen, and Katok explore an alternative arrangement of this process where all entrant suppliers are invited for bidding first before qualification screenings are selectively conducted afterward to determine the contract winner. This new approach helps reduce the waste of manufacturers’ screening efforts on suppliers with uncompetitive bids but in the meantime introduces incentives for less competitive supplier bidding behavior. They provide analytical and numerical evidence that this new approach could be very effective in managing manufacturers’ procurement costs.
Should closed reduction of the dislocated hip be attempted after failed Pavlik harness treatment in developmental dysplasia of the hip?
Authors: Arneill Matthew , Cosgrove Aidan , Robinson Elaine 
Published: August 2021

Aims To determine the likelihood of achieving a successful closed reduction (CR) of a dislocated hip in developmental dysplasia of the hip (DDH) after failed Pavlik harness treatment We report the rate of avascular necrosis (AVN) and the need for further surgical procedures. Methods Data was obtained from the Northern Ireland DDH database. All children who underwent an attempted closed reduction between 2011 and 2016 were identified. Children with a dislocated hip that failed Pavlik harness treatment were included in the study. Successful closed reduction was defined as a hip that reduced in theatre and remained reduced. Most recent imaging was assessed for the presence of AVN using the Kalamchi and MacEwen classification. Results There were 644 dislocated hips in 543 patients initially treated in Pavlik harness. In all, 67 hips failed Pavlik harness treatment and proceeded to arthrogram (CR) under general anaesthetic at an average age of 180 days. The number of hips that were deemed reduced in theatre was 46 of the 67 (69%). A total of 11 hips re-dislocated and underwent open reduction, giving a true successful CR rate of 52%. For the total cohort of 67 hips that went to theatre for arthrogram and attempted CR, five (7%) developed clinically significant AVN at an average follow-up of four years and one month, while none of the 35 hips whose reduction was truly successful developed clinically significant AVN. Conclusion The likelihood of a successful closed reduction of a dislocated hip in the Northern Ireland population, which has failed Pavlik harness treatment, is 52% with a clinically significant AVN rate of 7%. As such, we continue to advocate closed reduction under general anaesthetic for the hip that has failed Pavlik harness. Cite this article: Bone Jt Open 2021;2(8):594–598.