bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D virtual pre-operative planning may reduce the incidence of dorsal screw penetration in volar plating of intra-articular distal radius fractures
Authors: Prijs Jasper , Schoolmeesters Bram , Eygendaal Denise , de Vries Jean-Paul P. M. , Jutte Paul C. , Doornberg Job N. , Jaarsma Ruurd L. , IJpma Frank F. A. ,   on behalf of the Traumaplatform 3D Consortium
Published: October 2021

Abstract
Purpose
To evaluate the effect of three-dimensional virtual pre-operative planning (3DVP) on the incidence of dorsal screw penetration after volar plating of distal radius fractures.

Methods
A cross-sectional diagnostic imaging study was performed. Twenty out of 50 patients were randomly selected from our index prospective cohort (IPC): a prior study evaluating dorsal tangential views (DTVs) in reducing dorsal screw penetration in internal fixation of intra-articular distal radius fractures using post-operative CT scans to quantify screw protrusion. Pre-operative CTs from this cohort were now used for 3DVP by three experienced orthopaedic trauma surgeons (supplementary video). 3DVP was compared with the corresponding post-operative CT for assessing screw lengths and incidence of dorsal penetration. The Wilcoxon Signed Ranks test was used to compare screw lengths and the Fishers’ exact for incidence of penetration.

Results
Three surgeons performed 3DVP for 20 distal radius fractures and virtually applied 60 volar plates and 273 screws. Median screw length was shorter in the 3DVP when compared to IPC: 18 mm (range, 12–22) versus 20 mm (range, 14–26) (p < 0.001). The number of penetrating screws was 5% (13/273 screws) in the 3DVP group compared to 11% (10/91 screws) in the IPC (p = 0.047). Corresponding to a reduction in incidence of at least one dorsally penetrating screw in 40% of patients in the IPC group, to 18% in the 3DVP group (p = 0.069).

Conclusion
Three-Dimensional Virtual Pre-Operative Planning (3DVP) may reduce the incidence of dorsally penetrating screws in patients treated with volar plating for intra-articular distal radius fractures.

Level of evidence
II, diagnostic imaging study.
Social Mobility and Political Regimes: Intergenerational Mobility in Hungary, 1949–2017
Authors: Bukowski Paweł , Clark Gregory , Gáspár Attila , Pető Rita 
Published: October 2021

AbstractThis paper measures social mobility rates in Hungary during the period 1949 to 2017, using surnames to measure social status. In those years, there were two very different social regimes. The first was the Hungarian People’s Republic (1949–1989), which was a communist regime with an avowed aim of favouring the working class. The second is the modern liberal democracy (1989–2017), which is a free-market economy. We find five surprising things. First, social mobility rates were low for both upper- and lower-class families during 1949–2017, with an underlying intergenerational status correlation of 0.6–0.8. Second, social mobility rates under communism were the same as in the subsequent capitalist regime. Third, the Romani minority throughout both periods showed even lower social mobility rates. Fourth, the descendants of the eighteenth-century noble class in Hungary were still significantly privileged in 1949 and later. And fifth, although social mobility rates did not change measurably during the transition, the composition of the political elite changed rapidly and sharply.
Morphological and genetic divergence supports peripheral endemism and a recent evolutionary history of Chrysiptera demoiselles in the subtropical South Pacific
Authors: Liggins Libby , Kilduff Liam , Trnski Thomas , Delrieu-Trottin Erwan , Carvajal Jose I. , Arranz Vanessa , Planes Serge , Saenz-Agudelo Pablo , Aguirre J. David 
Published: October 2021

AbstractThe delineation of species and their evolutionary relationships informs our understanding of biogeography and how regional faunas are assembled. The peripheral geography and local environment of reefs in the subtropical South Pacific likely promotes the allopatric and adaptive divergence of taxa colonising from the tropics; however, the fauna of this region has been relatively understudied. Here, we address the taxonomic and evolutionary relationships among Chrysiptera taxa of the subtropical South Pacific. We use meristic counts, morphometrics and genetic markers to characterise the similarities and differences among four taxa restricted to the South Pacific region that have strikingly different colouration: C. notialis, a taxon restricted to eastern Australia, New Caledonia, Lord Howe Island and Norfolk Island; C. galba, found in the Cook Islands, southern French Polynesia and Pitcairn Islands; and the two disjunct populations of C. rapanui, found in the eastern Pacific around Rapa Nui (Isla de Pascua or Easter Island) and Motu Motiro Hiva (Salas y Gómez) and in the South-western Pacific around Rangitāhua (Kermadec Islands). Our morphometric analysis confirmed that these four taxa, including the two disjunct populations of C. rapanui, are morphologically distinct. However, our genetic analysis revealed that only C. rapanui from Rapa Nui was genetically differentiated, whereas C. rapanui of Rangitāhua, C. galba and C. notialis all shared a common haplotype. Furthermore, none of the taxa could be consistently differentiated based on individual meristic features. Our study reconciles a formerly perplexing and disjunct distribution for C. rapanui, to reveal that C. rapanui is an endemic of Rapa Nui and that the Chrysiptera of French Polynesia, Rangitāhua, and the South-western Pacific have only a very recent history of divergence. Our analyses suggest these subtropical taxa have diverged from a predominantly tropical Chrysiptera genus in morphological features important in determining colonisation success, locomotion and feeding ecology.
Das gute Leben
Authors: Woopen Christiane , Wagner Michael , Zank Susanne 
Published: October 2021

ZusammenfassungIm abschließenden Beitrag stellen die Autor*innen das Konzept „gelingende Lebensführung“ in den Mittelpunkt. Die Kernergebnisse der vorhergehenden Beiträge werden zusammengefasst und im Rahmen einer kritischen Diskussion in dieses Konzept eingeordnet. Vor dem Hintergrund werden Empfehlungen für die politische und gesellschaftliche Gestaltung von Rahmenbedingungen formuliert, die einer gelingenden Lebensführung im sehr hohen Alter dienlich sind und sie fördern.
Discrepancies between subjective importance and actual everyday practice among very old adults and the consequences for autonomy
Authors: Geithner Luise , Wagner Michael 
Published: October 2021

Abstract
Background
An individual’s everyday practice in very old age is based on stable dispositions and on the living conditions associated with the person’s stage of life. Age-associated changes in living conditions can cause discrepancies between the person’s dispositions and actual everyday practice that have consequences for the quality of life.

Objective
The aim of this paper is to look more closely at such discrepancies and their associations with living conditions in very old age (long-term care needs, multimorbidity, care tasks) as well as with the feeling of autonomy as an aspect of quality of life.

Methods
A cross-sectional analysis was conducted using data from the first wave of the NRW80+-study on the quality of life of people aged 80 years and over. Data on the subjective importance of five areas of everyday practice and on the frequency of translating these dispositions into practice were used. The analysis focuses on the occurrence of large discrepancies that arise if the subjective importance of an everyday practice deviates considerably from the frequency of performing it.

Results
Among the very old population surveyed, solitary activities are considered the most important, and they are carried out most often. Multimorbidity, long-term care needs, and private care responsibilities are significantly associated with the experience of large discrepancies. Finally, very old adults with large discrepancies report feelings of reduced autonomy.

Conclusion
These initial results show that age-associated changes in living conditions can be accompanied by difficulties for very old adults to put their dispositions into practice. Attention should be paid to such discrepancies to avoid negative consequences for quality of life.
FLAIR2 post-processing: improving MS lesion detection in standard MS imaging protocols
Authors: Zrzavy Tobias , Wielandner Alice , Haider Lukas , Bartsch Sophie , Leutmezer Fritz , Berger Thomas , Nenning Karl Heinz , Rauscher Alexander , Rommer Paulus , Kasprian Gregor 
Published: October 2021

Abstract
Background
Technical improvements in magnetic resonance imaging (MRI) acquisition, such as higher field strength and optimized sequences, lead to better multiple sclerosis (MS) lesion detection and characterization. Multiplication of 3D-FLAIR with 3D-T2 sequences (FLAIR2) results in isovoxel images with increased contrast-to-noise ratio, increased white–gray-matter contrast, and improved MS lesion visualization without increasing MRI acquisition time. The current study aims to assess the potential of 3D-FLAIR2 in detecting cortical/leucocortical (LC), juxtacortical (JC), and white matter (WM) lesions.

Objective
To compare lesion detection of 3D-FLAIR2 with state-of-the-art 3D-T2-FLAIR and 3D-T2-weighted images.

Methods
We retrospectively analyzed MRI scans of thirteen MS patients, showing previously noted high cortical lesion load. Scans were acquired using a 3 T MRI scanner. WM, JC, and LC lesions were manually labeled and manually counted after randomization of 3D-T2, 3D-FLAIR, and 3D-FLAIR2 scans using the ITK-SNAP tool.

Results
LC lesion visibility was significantly improved by 3D-FLAIR2 in comparison to 3D-FLAIR (4 vs 1; p = 0.018) and 3D-T2 (4 vs 1; p = 0.007). Comparing LC lesion detection in 3D-FLAIR2 vs. 3D-FLAIR, 3D-FLAIR2 detected on average 3.2 more cortical lesions (95% CI − 9.1 to 2.8). Comparing against 3D-T2, 3D-FLAIR2 detected on average 3.7 more LC lesions (95% CI 3.3–10.7).

Conclusions
3D-FLAIR2 is an easily applicable time-sparing MR post-processing method to improve cortical lesion detection. Larger sampled studies are warranted to validate the sensitivity and specificity of 3D-FLAIR2.
Attrition und Osmokinetik – Zwei Konzepte zur Pathogenese des Trockenen Auges
Authors: van Setten Gysbert-Botho 
Published: October 2021

ZusammenfassungDie neuen Erkenntnisse der Pathophysiolgie des Trockenen Auges erkennen das Zusammenspiel von Tränen, Augenoberfläche und Lidoberfläche als eine funktionelle Einheit an. Der Begriff der Benetzungsfähigkeit der Tränen in Abhängigkeit der mikrotektonischen Anatomie der Augenoberfläche relativiert die Anforderungen an Träne und Tränenersatzmittel. Das Model der Attrition, welches die Effekte der friktionsneutralisierenden Kapazität des Tränenfilms, der Reibung und die Bedeutung der Mechanotransduktionskapazität des Epithels zusammenfasst, wird eingeführt und dessen pathophysiologische Bedeutung erläutert. Attrition und Benetzung bestimmen zusammen grundlegende pathophysiologische Vorgänge in der Augenoberfläche wie Aktivierung von Nerven (subjektive Beschwerden) sowie Entzündung und beeinflussen damit die Dynamik der Pathophysiologie, und den Übergang von vorübergehenden Beschwerden zu einer manifesten Erkrankung des Trockenen Auges. Die Betrachtung der Osmolarität als numerischer statischer Grenzwert zur alleinigen Diagnose des Trockenen Auges ist klinisch nicht haltbar. Das neue, dynamische Model der Osmokinetik, zeigt dagegen eine Alternative auf, in der die Tageschwankungen und die Beachtung des durchschnittlichen Osmolaritätsniveaus gröβere Bedeutung gewinnen und damit der eigentlichen pathophysiologischen Bedeutung der Osmolarität gerechter wird.
STAndard Reporting of CAries Detection and Diagnostic Studies (STARCARDDS)
Authors: Neuhaus Klaus W. , Eggmann Florin , Kühnisch Jan , Kapor Svetlana , Janjic Rankovic Mila , Schüler Ina , Krause Felix , Lussi Adrian , Michou Stavroula , Ekstrand Kim , Huysmans Marie-Charlotte 
Published: October 2021

Abstract

Aim
The aim of this paper is to present recommendations from an international workshop which evaluated the methodology and reporting of caries diagnostic studies. As a unique feature, this type of studies is focused on caries lesion detection and assessment, and many of them are carried out in vitro, because of the possibility of histological validation of the whole caries spectrum. This feature is not well covered in the existing reporting STARD guideline within the EQUATOR Network.

Participants and methods
An international working group of 13 cariology researchers was formed. The STARD checklist was reviewed and modified for caries detection and diagnosis purposes, in a three-step process of evaluation, consensual modification, and delivery during three 2-day workshops over 18 months. Special attention was paid to reporting requirements of caries studies that solely focus on reliability.

Results
The STARD checklist was modified in 14/30 items, with an emphasis on issues of sample selection (tooth selection in in vitro studies), blinding, and detailed reporting of results.

Conclusion
Following STARCARDDS (STAndard Reporting of CAries Detection and Diagnostic Studies) is expected to result in complete reporting of study design and methodology in future caries diagnosis and detection experiments both in vivo and in vitro, thus allowing for better comparability of studies and higher quality of systematic reviews.

Clinical relevance
Standardization of caries diagnostic studies leads to a better comparability among future studies, both in vivo and in vitro.
Frequency of the necessity of dentoalveolar surgery or conservative treatment in patients before kidney transplantation depending on the duration of dialysis and causative nephrological disease
Authors: Moest Tobias , Lutz Rainer , Jahn Arne Eric , Heller Katharina , Schiffer Mario , Adler Werner , Deschner James , Weber Manuel , Kesting Marco Rainer 
Published: October 2021

AbstractObjectivesThis retrospective study evaluates intraoral surgical and conservative treatment need in patients with a chronic kidney end-stage disease, depending on the duration of dialysis treatment and the causative nephrological disease.Material and methodsThis study is based on data of patients referred to the Department of Oral and Maxillofacial Surgery of the University Hospital Erlangen, Germany, prior to kidney transplantation between January 2015 and March 2020. The necessity for oral surgical or dental therapy was determined by clinical and radiological examinations. Data on renal replacement therapy, cause of underlying renal disease, lifestyle, and general health were collected.ResultsData ofN= 89 patients demonstrated that surgical treatment need depends on dialysis duration (p= 0.042). Patients, who had been dialyzing for 2 to 3 years showed the highest need for surgical intervention (80.0%;p= 0.024), followed by dialysis patients with a dialysis time of more than 3 years (48.1%). Similarly, dialysis patients in the second or third year of dialysis had the highest need for conservative treatment (73.3%;p> 0.05), followed by 55.6% of dialysis patients in the third year of dialysis.ConclusionsOperative and conservative treatment is essential to optimize subsequent kidney transplantation. The greatest necessity could be detected for patients in the second and third years of dialysis.Clinical relevanceOral health addressing surgical and conservative treatment need depends on the duration of dialysis in patients with a chronic kidney end-stage disease.
The Danubian cryptic invader Theodoxus fluviatilis (Gastropoda: Neritidae) in the River Rhine: a potential indicator for metal pollution?
Authors: Rothmeier Louisa Marie , Martens Andreas , Watermann Burkard , Grabow Karsten , Bartz Jennifer , Sahm René 
Published: October 2021

AbstractMetal pollution poses a major threat to aquatic systems especially in anthropogenic influenced areas, in as much as metals are persistent in the environment. The freshwater snail Theodoxus fluviatilis has often been used as an indicator species for the ecological status in river monitoring. In the River Rhine, the native Northern-European form of T. fluviatilis is nowadays extinct, whilst the Danubian form is spreading along the river. The aim of our study was to investigate if the cryptic invader is affected by metal exposure present in the River Rhine and to discuss its potential as an indicator for metal pollution. Several environmental abiotic (14 water environmental variables plus five common metal concentrations in water and biofilm) and biotic parameters (biofilm mass) were measured across 23 sites along the River Rhine. Five population and six histopathological parameters were evaluated on snails collected at all 23 sites. Aqueous chromium concentration was positively correlated to the damage of male reproductive organs of T. fluviatilis, and higher ammonium concentration was correlated to a decrease in snail size and an increase in the proportion of juveniles. None of the analysed snail parameters was negatively correlated to concentrations of other metals measured, like copper and zinc. Therefore, based on the parameters evaluated, our results indicate that the Danubian form of T. fluviatilis is only restrictedly suitable as an indicator for metal pollution in the River Rhine system. Further field and laboratory investigations including other stressors are necessary to evaluate the indicator potential of the cryptic invader holistically.
Quantifying loss aversion: Evidence from a UK population survey
Authors: Blake David , Cannon Edmund , Wright Douglas 
Published: October 2021

AbstractWe quantify differences in attitudes to loss from individuals with different demographic, personal and socio-economic characteristics. Our data are based on responses from an online survey of a representative sample of over 4000 UK residents and allow us to produce the most comprehensive analysis of the heterogeneity of loss aversion measures to date. Using the canonical model proposed by Tversky and Kahneman (1992), we show that responses for the population as a whole differ substantially from those typically provided by students (who form the basis of many existing studies of loss aversion). The average aversion to a loss of £500 relative to a gain of the same amount is 2.41, but loss aversion correlates significantly with characteristics such as gender, age, education, financial knowledge, social class, employment status, management responsibility, income, savings and home ownership. Other related factors include marital status, number of children, ease of savings, rainy day fund, personality type, emotional state, newspaper and political party. However, once we condition on all the profiling characteristics of the respondents, some factors, in particular gender, cease to be significant, suggesting that gender differences in risk and loss attitudes might be due to other factors, such as income differences.
Mesenchymal Stem Cell-derived Extracellular Vesicles Transmitting MicroRNA-34a-5p Suppress Tumorigenesis of Colorectal Cancer Through c-MYC/DNMT3a/PTEN Axis
Authors: Zhao Jiangning , Lin Huanrong , Huang Kunsong 
Published: October 2021

AbstractMesenchymal stem cell–derived extracellular vesicles (MSC-EV) can transport microRNAs (miRNAs) into colorectal cancer (CRC) cells, thus to inhibit the malignant phenotype of cancer cells. Whether MSC-EV could deliver miR-34a-5p to suppress CRC development was surveyed through the research. miR-34a-5p, c-MYC, DNA methyltransferase 3a (DNMT3a), and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression were measured in CRC tissues and cell lines. miR-34a-5p and c-MYC expression were altered by transfection in HCT-116 cells. MSC-EV were transfected with miR-34a-5p- and c-MYC-related oligonucleotides and co-cultured with HCT-116 cells. HCT-116 cell growth after treatment was observed. Furthermore, the functional roles of miR-34a-5p and c-MYC were explored in vivo. The combined interactions of miR-34a-5p/c-MYC/DNMT3a/PTEN axis were assessed. miR-34a-5p and PTEN were downregulated while c-MYC and DNMT3a were upregulated in CRC. Depletion of miR-34a-5p drove while that of c-MYC restricted CRC cell growth. MSC-EV retarded CRC progression. Moreover, MSC-EV carrying overexpressed miR-34a-5p or depleted c-MYC further disrupted CRC cell progression. miR-34a-5p targeted c-MYC to regulate DNMT3a and PTEN. c-MYC overexpression abrogated EV-derived miR-34a-5p upregulation-induced effects on CRC. Restoring miR-34a-5p or depleting c-MYC in MSC-EV limited CRC tumor formation. MSC-EV-derived miR-34a-5p depresses CRC development through modulating the binding of c-MYC to DNMT3a and epigenetically regulating PTEN.
Emerging roles of the HECT-type E3 ubiquitin ligases in hematological malignancies
Authors: Delvecchio Vincenza Simona , Fierro Claudia , Giovannini Sara , Melino Gerry , Bernassola Francesca 
Published: October 2021

AbstractUbiquitination-mediated proteolysis or regulation of proteins, ultimately executed by E3 ubiquitin ligases, control a wide array of cellular processes, including transcription, cell cycle, autophagy and apoptotic cell death. HECT-type E3 ubiquitin ligases can be distinguished from other subfamilies of E3 ubiquitin ligases because they have a C-terminal HECT domain that directly catalyzes the covalent attachment of ubiquitin to their substrate proteins. Deregulation of HECT-type E3-mediated ubiquitination plays a prominent role in cancer development and chemoresistance. Several members of this subfamily are indeed frequently deregulated in human cancers as a result of genetic mutations and altered expression or activity. HECT-type E3s contribute to tumorigenesis by regulating the ubiquitination rate of substrates that function as either tumour suppressors or oncogenes. While the pathological roles of the HECT family members in solid tumors are quite well established, their contribution to the pathogenesis of hematological malignancies has only recently emerged. This review aims to provide a comprehensive overview of the involvement of the HECT-type E3s in leukemogenesis.
Applying Evidential Pluralism to the social sciences
Authors: Shan Yafeng , Williamson Jon 
Published: October 2021

AbstractEvidential Pluralism maintains that in order to establish a causal claim one normally needs to establish the existence of an appropriate conditional correlation and the existence of an appropriate mechanism complex, so when assessing a causal claim one ought to consider both association studies and mechanistic studies. Hitherto, Evidential Pluralism has been applied to medicine, leading to the EBM+ programme, which recommends that evidence-based medicine should systematically evaluate mechanistic studies alongside clinical studies. This paper argues that Evidential Pluralism can also be fruitfully applied to the social sciences. In particular, Evidential Pluralism provides (i) a new approach to evidence-based policy; (ii) a new account of the evidential relationships in more theoretical research; and (iii) new philosophical motivation for mixed methods research. The application of Evidential Pluralism to the social sciences is also defended against two objections.