bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing eScreening for suicide prevention in VA post-9/11 transition programs using a stepped-wedge, mixed-method, hybrid type-II implementation trial: a study protocol
Authors: Pittman James O. E. , Lindamer Laurie , Afari Niloofar , Depp Colin , Villodas Miguel , Hamilton Alison , Kim Bo , Mor Maria K. , Almklov Erin , Gault John , Rabin Borsika 
Published: April 2021

AbstractBackgroundPost-9/11 veterans who enroll in VA health care frequently present with suicidal ideation and/or recent suicidal behavior. Most of these veterans are not screened on their day of enrollment and their risk goes undetected. Screening for suicide risk, and associated mental health factors, can lead to early detection and referral to effective treatment, thereby decreasing suicide risk. eScreening is an innovative Gold Standard Practice with evidence to support its effectiveness and implementation potential in transition and care management (TCM) programs. We will evaluate the impact of eScreening to improve the rate and speed of suicide risk screening and referral to mental health care compared to current screening methods used by transition care managers. We will also evaluate the impact of an innovative, multicomponent implementation strategy (MCIS) on the reach, adoption, implementation, and sustained use of eScreening.MethodsThis is an eight-site 4-year, stepped-wedge, mixed-method, hybrid type-II implementation trial comparing eScreening to screening as usual while also evaluating the potential impact of the MCIS focusing on external facilitation and Lean/SixSigma rapid process improvement workshops in TCM. The aims will address: 1) whether using eScreening compared to oral and/or paper-based methods in TCM programs is associated with improved rates and speed of PTSD, depression, alcohol, and suicide screening & evaluation, and increased referral to mental health treatment; 2) whether and to what degree our MCIS is feasible, acceptable, and has the potential to impact adoption, implementation, and maintenance of eScreening; and 3) how contextual factors influence the implementation of eScreening between high- and low-eScreening adopting sites. We will use a mixed methods approach guided by the RE-AIM outcomes of the Practical Robust Implementation and Sustainability Model (PRISM). Data to address Aim 1 will be collected via medical record query while data for Aims 2 and 3 will be collected from TCM staff questionnaires and qualitative interviews.DiscussionThe results of this study will help identify best practices for screening in suicide prevention for Post-9/11 veterans enrolling in VA health care and will provide information on how best to implement technology-based screening into real-world clinical care programs.Trial registrationClinicalTrials.gov: NCT04506164; date registered: August 20, 2020; retrospectively registered
Impact of the COVID-19 pandemic on the mental health and well-being of UK healthcare workers
Authors: Gilleen James , Santaolalla Aida , Valdearenas Lorena , Salice Clara , Fusté Montserrat 
Published: April 2021

Background
The coronavirus disease 2019 (COVID-19) pandemic has had a significant psychological impact on healthcare workers (HCWs).

Aims
There is an urgent need to understand the risk and protective factors associated with poor mental well-being of UK HCWs working during the COVID-19 pandemic.

Method
Shortly after the April 2020 UK COVID-19 peak 2773 HCWs completed a survey containing measures of anxiety, depression, post-traumatic stress disorder and stress, as well as questions around potential predictors such as roles, COVID-19 risk perception and workplace-related factors. Respondents were classified as high or low symptomatic on each scale and logistic regression revealed factors associated with severe psychiatric symptoms. Change in well-being from pre- to during COVID-19 was also quantified.

Results
Nearlya third of HCWs reported moderate to severe levels of anxiety and depression, and the number reporting very high symptoms was more than quadruple that pre-COVID-19. Several controllable factors were associated with the most severe level of psychiatric symptoms: insufficient personal protective equipment availability, workplace preparation, training and communication, and higher workload. Being female, ‘front line’, previous psychiatric diagnoses, traumatic events, and being an allied HCW or manager were also significantly associated with severe psychiatric symptoms. Sharing stress, resilience and ethical support for treatment decisions were significantly associated with low psychiatric symptoms. Front-line workers showed greater worsening of mental health compared with non-front-line HCWs.

Conclusions
Poor mental well-being was prevalent during the COVID-19 response, however, controllable factors associated with severe psychiatric symptoms are available to be targeted to reduce the detrimental impact of COVID-19 and other pandemics on HCW mental health.
Cure and Hormonal Control After Prolactinoma Resection: Case Series and Systematic Review
Authors: Penn Marisa C , Cardinal Tyler , Zhang Yanchen , Abt Brittany , Bonney Phillip A , Lorenzo Patricia , Lin Michelle , Rosner Jack , Weiss Martin , Zada Gabriel , Carmichael John D 
Published: April 2021

Abstract

Context
Surgical management of prolactinomas is an important treatment for patients intolerant of dopamine agonist therapy. However, predictors of postoperative outcomes remain unclear.

Object
While transsphenoidal surgical resection (TSSR) is important second-line therapy in prolactinoma patients, predictors of surgical cure and biochemical remission following TSSR remain sparse.

Methods
A retrospective review of prolactinoma patients undergoing TSSR at the USC Pituitary Center from 1995 to 2020 was conducted. Participants were categorized as surgical cure (normalization of serum prolactin without medical treatment), surgical noncure, biochemical control (prolactin normalization with or without adjuvant therapy), and nonbiochemical control. A systematic review of the outcomes of surgically managed prolactinomas was performed.

Results
The 40 female and 16 male participants had an average age of 35.6 years. Prior treatment included transsphenoidal resection (6, 11%) and dopamine agonist treatment (47, 84%). The 40 macroadenomas and 15 microadenomas exhibited suprasellar extension (24, 43%) and parasellar invasion (20, 36%). Fifteen (27%) were purely intrasellar. Gross total resection was achieved in 25 patients (45%) and subtotal in 26 (46%). Surgical cure was achieved in 25 patients (46%) and biochemical control in 35 (64%). Surgical cure was more likely in smaller, noninvasive tumors, those that were fully resected, and patients with lower preoperative (&lt; 1000 ng/mL) and immediately postoperative (&lt; 7.6 ng/mL) prolactin levels. Ten of 26 patients (38%) undergoing adjuvant therapy achieved biochemical control, which was less likely in men and those with higher preoperative prolactin or invasive tumors.

Conclusion
Surgical resection of prolactinomas is a safe procedure that, when offered judiciously, can achieve symptom and/or biochemical control in a majority of patients. A variety of predictors may be useful in advising patients on likelihood of postoperative remission.
Are cone beam CT image matching skills transferrable from planning CT to planning MRI for MR-only prostate radiotherapy?
Authors: Brooks Rachel L , McCallum Hazel M , Pearson Rachel A , Pilling Karen , Wyatt Jonathan 
Published: April 2021

Objectives:
Treatment verification for MR-only planning has focused on fiducial marker matching, however, these are difficult to identify on MR. An alternative is using the MRI for soft-tissue matching with cone beam computed tomography images (MR-CBCT). However, therapeutic radiographers have limited experience of MRI. This study aimed to assess transferability of therapeutic radiographers CT-CBCT prostate image matching skills to MR-CBCT image matching.

Methods:
23 therapeutic radiographers with 3 months–5 years’ experience of online daily CT-CBCT soft-tissue matching prostate cancer patients participated. Each observer completed a baseline assessment of 10 CT-CBCT prostate soft-tissue image matches, followed by 10 MR-CBCT prostate soft-tissue image match assessment. A MRI anatomy training intervention was delivered and the 10 MR-CBCT prostate soft-tissue image match assessment was repeated. Limits of agreement were calculated as the disagreement of the observers with mean of all observers.

Results:
Limits of agreement at CT-CBCT baseline were 2.8 mm, 2.8 mm, 0.7 mm (vertical, longitudinal, lateral). MR-CBCT matches prior to training were 3.3 mm, 3.1 mm, 0.9 mm, and after training 2.6 mm, 2.4 mm, 1.1 mm (vertical, longitudinal, lateral). Results show similar limits of agreement across the assessments, and variation reduced following the training intervention.

Conclusion:
This suggests therapeutic radiographers’ prostate CBCT image matching skills are transferrable to a MRI planning scan, since MR-CBCT matching has comparable observer variation to CT-CBCT matching.

Advances in knowledge:
This is the first publication assessing interobserver MR-CBCT prostate soft tissue matching in an MR-only pathway.
An Empirical Bargaining Model with Left-Digit Bias: A Study on Auto Loan Monthly Payments
Authors: Jiang Zhenling 
Published: April 2021

This paper studies price bargaining when both parties have left-digit bias when processing numbers. The empirical analysis focuses on the auto finance market in the United States, using a large data set of 35 million auto loans. Incorporating left-digit bias in bargaining is motivated by several intriguing observations. The scheduled monthly payments of auto loans bunch at both $9- and $0-ending digits, especially over $100 marks. In addition, $9-ending loans carry a higher interest rate, and $0-ending loans have a lower interest rate. We develop a Nash bargaining model that allows for left-digit bias from both consumers and finance managers of auto dealers. Results suggest that both parties are subject to this basic human bias: the perceived difference between $9- and the next $0-ending payments is larger than $1, especially between $99- and $00-ending payments. The proposed model can explain the phenomena of payments bunching and differential interest rates for loans with different ending digits. We use counterfactuals to show a nuanced impact of left-digit bias, which can both increase and decrease the payments. Overall, bias from both sides leads to a $33 increase in average payment per loan compared with a benchmark case with no bias. This paper was accepted by Matthew Shum, marketing.
SUSTENTABILIDADE EM PRÉDIOS E OBRAS PÚBLICAS: ANÁLISE EM UMA INSTITUIÇÃO DE ENSINO SUPERIOR
Authors: Mariano Dailleny Chagas de Oliveira , Trigo Aline Guimarães Monteiro , Maruyama Ursula Gomes Rosa 
Published: April 2021

O crescimento econômico no mundo atraiu as grandes indústrias e induziu a população a um consumo acelerado. Com isso, houve um desequilíbrio no qual a sociedade passou a conviver com a desigualdade, gerando uma preocupação com a qualidade de vida humana associada à escassez de recursos naturais. Da mesma maneira, as construções começaram a acelerar, sem planejamento e acarretaram diversos tipos de impactos ambientais. Essa situação implicou na necessidade de rever os conceitos a respeito de como as pessoas estão vivendo e consumindo. Os governos optaram por incentivar práticas sustentáveis e buscaram adequar-se a uma relação de melhor custo benefício. Neste contexto, leis são elaboradas e impõem a utilização de recursos renováveis e a redução de materiais, além do incentivo à economia do reaproveitamento. Por isso, este artigo tem como objetivo criar uma agenda de critérios de sustentabilidade para projetos de obras em uma instituição de ensino superior, como o Centro Federal de Educação Tecnológica Celso Suckow da Fonseca (CEFET/RJ), tendo como referência os documentos exigidos pela Administração Pública Federal (IN nº 01/2010 e a Lei nº 111/2011), a partir de uma pesquisa qualitativa e exploratória. Os primeiros resultados, a partir das análises observadas, demonstram que três quartos dos critérios são atendidos. Contudo, torna-se necessário um estudo aprofundado para que todos os critérios, colocados em lei, sejam atendidos e viabilizados durante a concepção do projeto de arquitetura com a participação, em conjunto, das equipes de licitação, de orçamento e dos projetos complementares.
Autologous stem cell implantation with core decompression for avascular necrosis of the femoral head using a new device
Authors: Khan MNH , Abbas K , Ayling EA , Waqas Ilyas M , Dunlop DG 
Published: April 2021

Introduction Autologous stem cell progenitor implantation into necrotic lesions of the femoral head has previously been described as a potential treatment for avascular necrosis (AVN), on the basis that there is a reduced number of functioning stem cells in the marrow within the necrotic segment. We present a case series of patients with AVN that underwent core decompression with autologous stem cell implantation using a new device. Methods The records and imaging of patients with AVN of the femoral head treated by a single surgeon were retrospectively reviewed. All patients were treated with core decompression and stem cell progenitor implantation, using the PerFuse system. Preoperatively, demographic information, AVN staging (as per Ficat and Arlet classification) and visual analogue pain scores (VAS) of the hips were recorded. These results were compared with postoperative VAS and imaging, with further review on the progression of AVN. Results We treated 14 hips in 13 patients with an average follow up of 12 months. Patients with Ficat I–II were selected for the procedure. The average preoperative VAS was 3.9. Postoperatively, this dropped to 2.6, with over half of patients reporting at least a two-point decrease in pain. Eight of the 14 treated hips showed no radiological progression of the disease, while six showed femoral head collapse requiring total hip arthroplasty (THA) at an average of ten months after treatment. Conclusion Our early findings indicate that hip decompression with stem cell progenitor implantation for AVN of the femoral head provides symptomatic relief and may be beneficial in arresting progression of disease using this simple new device.
TGFβ1, MMPs and cytokines profiles in ocular surface: Possible tear biomarkers for pseudoexfoliation
Authors: Sahay Prity , Reddy Shweta , Prusty Birendra Kumar , Modak Rahul , Rao Aparna 
Published: April 2021

Purpose
Pseudoexfoliation (PXF) is a unique form of glaucoma characterized by accumulation of exfoliative material in the eyes. Changes in tear profile in disease stages may give us insights into molecular mechanisms involved in causing glaucoma in the eye.

Methods
All patients were categorized into three main categories; pseudoexfoliation (PXF), pseudoexfoliation glaucoma (PXG) and cataract, which served as control. Cytokines, transforming growth factor β1 (TGFβ1), matrix metalloproteases (MMPs) and fibronectin (FN1) were assessed with multiplex bead assay, enzyme-linked immunosorbent assay (ELISA), gelatin zymography, and immunohistochemistry (IHC) respectively in different ocular tissues such as tears, tenon’s capsule, aqueous humor (AH) and serum samples of patients with PXF stages.

Results
We found that TGFβ1, MMP-9 and FN1 protein expression were upregulated in tears, tenon’s capsule and AH samples in PXG compared to PXF, though the MMP-9 protein activity was downregulated in PXG compared with control or PXF. We have also found that in PXG tears sample the fold change of TGF-α (Transforming Growth Factor-α), MDC (Macrophage Derived Chemokine), IL-8 (Interleukin-8), VEGF (Vascular Endothelial Growth Factor) were significantly downregulated and the levels of GM-CSF (Granulocyte Macrophage Colony Stimulating Factor), IP-10 (Interferon- γ produced protein-10) were significant upregulated. While in AH; IL-6 (Interleukin-6), IL-8, VEGF, IFN-a2 (Interferon- α2), GRO (Growth regulated alpha protein) levels were found lower and IL1a (Interleukin-1α) level was higher in PXG compared to PXF. And in serum; IFN-a2, Eotaxin, GM-CSF, Fractalkine, IL-10 (Interleukin-10), IL1Ra (Interleukin-1 receptor antagonist), IL-7 (Interleukin-7), IL-8, MIP1β (Macrophage Inflammatory Protein-1β), MCP-1 (Monocyte Chemoattractant Protein-1) levels were significantly upregulated and PDGF-AA (Platelet Derived Growth Factor-AA) level was downregulated in the patients with PXG compared to PXF.

Conclusions
Altered expression of these molecules in tears may therefore be used as a signal for onset of glaucoma or for identifying eyes at risk of developing glaucoma in PXF.
Perspectives of compounding pharmacists on alcohol-based hand sanitizer production and utilization for COVID-19 prevention in Addis Ababa, Ethiopia: A descriptive phenomenology study
Authors: Baye Assefa Mulu , Ababu Andualem , Bayisa Regasa , Abdella Mahdi , Diriba Edessa , Wale Minyechel , Selam Muluken Nigatu 
Published: April 2021

Background
Globally, the safety of patients and healthcare providers is at risk due to health care-associated infections (HCAIs). World Health Organization and the Centers for Disease Control and Prevention recommend using alcohol-based hand rub (ABHR) for hand hygiene in healthcare settings to prevent HCAIs. Irrational use of ABHR will have undesirable consequences including wastage of products, exposure of healthcare providers to infections and emergence of microbial resistance to the alcohol in hand sanitizers. This study aimed to explore the perspective and experiences of compounding pharmacists on production and utilization of ABHR solution for coronavirus disease in 2019 (COVID-19) prevention in public hospitals of Addis Ababa, Ethiopia.

Methods
A descriptive qualitative study using in-depth interview of 13 key-informants serving as compounding pharmacists in public hospitals of Addis Ababa, Ethiopia, was conducted. The study participants were identified and selected by purposive sampling. All transcribed interviews were subjected to thematic analysis and transcripts were analyzed manually.

Findings
The compounding pharmacists in this study had a mean age of 30.6 (±3.1) years and nine of the thirteen participants were men. Ten participants believed that the compounding practice in their respective sites followed the principles of good compounding practice. More than half of the participants did not believe that ABHR products were used rationally in health facilities. They argued that users did not have enough awareness when and how to use sanitizers. Most of the interviewees reported that compounding personnel had no formal training on ABHR solution production. Study participants suggested incentive mechanisms and reimbursements for experts involved in the compounding of ABHR solutions.

Conclusion
Three of the compounding pharmacists indicated that ABHR production in their setting lack compliance to good compounding practice due to inadequate compounding room, quality control tests, manpower and equipment. Despite this, most study participants preferred the in-house ABHR products than the commercially available ones. Thus, training, regular monitoring and follow-up of the hospital compounding services can further build staff confidence.
Use of rehabilitation services by persons with disabilities in Brazil: A multivariate analysis from Andersen’s behavioral model
Authors: Medeiros Arthur de Almeida , Galvão Maria Helena Rodrigues , Barbosa Isabelle Ribeiro , Oliveira Angelo Giuseppe Roncalli da Costa 
Published: April 2021

Background
For many years, discussions about health care for people with disabilities (PwD) in Brazil have not been treated as a priority; however, based on the advances made at the beginning of this century, new policies have been developed with the aim of improving access of these people to health services. Therefore, the aim of this study was to analyze how individual characteristics and contextual indicators are associated with access to rehabilitation services for PwD in Brazil.

Methods
A multivariate analysis was performed based on data from the National Health Survey 2013, considering access to rehabilitation services by PwD as the primary outcome and individual and contextual factors selected from Andersen’s behavioral model as independent variables. The contextual variables were reduced to two composite indicators (1-primary health care coverage and unfavorable socioeconomic conditions, and 2-economic inequality) from the analysis of the principal components. Poisson regression analysis with robust variance was performed to estimate the prevalence ratio (PR) and the respective 95% confidence interval (95%CI).

Results
Access to rehabilitation services by PwD was more prevalent in people aged 0 to 17 years (PR = 3.28; 95%CI 2.85–3.78), who are illiterate (PR = 1.24; 95%CI 1.09–1.40), whose socioeconomic level is A or B (PR = 1.60; 95%CI 1.35–1.88), who have health insurance (PR = 1.31; 95%CI 1.15–1.49), who have severe limitations (PR = 3.09; 95%CI 2.64–3.62), who live in states with a good offer of Specialized Rehabilitation Centers, both type II (PR = 1.20; CI95% 1.08; 1.33) and type IV (PR = 1.29; CI95% 1.15; 1.44), and who have greater coverage of primary health care, but unfavorable socioeconomic conditions (PR = 1.15; CI95% 1.03–1.28).

Conclusion
The results clarify the social inequities that exist regarding access to rehabilitation services for PwD in Brazil and highlight the need to formulate and implement public policies that guarantee the realization of the rights of these people.
Validitas dan Reliabilitas Ages & Stages Questionnaire: Social-Emotional 2 versi Indonesia Validitas dan Reliabilitas Ages & Stages Questionnaire: Social-Emotional 2 versi Indonesia
Authors: Cesilia Citra , Wulandari Diah Asri , Dhamayanti Meita 
Published: April 2021

Latar belakang. Identifikasi dini gangguan sosial, emosi, dan perilaku merupakan hal penting untuk anak usia 3 tahun kebawah. Saat ini belum ada instrumen skrining untuk kelompok usia tersebut.Tujuan. Untuk menilai validitas dan reliabilitas Kuesioner Ages & Stages Questionnaire: Social-Emotional 2 versi Indonesia Metode. Studi ini merupakan studi potong-lintang yang dilakukan pada periode Agustus 2018 hingga November 2018 di Puskesmas Garuda, Bandung, Indonesia. Hasil. Sebanyak 659 dari 689 anak-anak terlibat pada studi ini. Hasil Cronbach’s alpha berkisar 0,486-0,779 sedangkan metode Split-half berkisar 0,08-0,91. Koefisien korelasi studi ini sebesar 0,68-0,95.Kesimpulan. Uji validitas ASQ:SE-2 pada usia 12-36 bulan memenuhi kriteria validitas. Uji reliabilitas menggunakan Cronbach alpha pada kelompok usia 18, 24, dan 30 bulan memiliki reliabilitas yang cukup baik, adapun pada kelompok usia 12 bulan hasil uji reliabilitas dibawah cut-off point yang menunjukkan hasil tidak reliabel.