bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling geographical accessibility to urban centres in Kenya in 2019
Authors: Macharia Peter M. , Mumo Eda , Okiro Emelda A. 
Published: May 2021

Background
Access to major services, often located in urban centres, is key to the realisation of numerous Sustainable Development Goals (SDGs). In Kenya, there are no up-to-date and localised estimates of spatial access to urban centres. We estimate the travel time to urban centres and identify marginalised populations for prioritisation and targeting.

Methods
Urban centres were mapped from the 2019 Kenya population census and combined with spatial databases of road networks, elevation, land use and travel barriers within a cost-friction algorithm to compute travel time. Seven travel scenarios were considered: i) walking only (least optimistic), ii) bicycle only, iii) motorcycle only, iv) vehicle only (most optimistic), v) walking followed by motorcycle transport, vi) walking followed by vehicle transport, and vii) walking followed by motorcycle and then vehicle transport (most pragmatic). Mean travel time, and proportion of the population within 1-hour and 2-hours of the urban centres were summarized at sub-national units (counties) used for devolved planning. Inequities were explored and correlations between the proportion of the population within 1-hour of an urban centre and ten SDG indicators were computed.

Results
A total of 307 urban centres were digitised. Nationally, the mean travel time was 4.5-hours for the walking-only scenario, 1.0-hours for the vehicle only (most optimistic) scenario and 1.5-hours for the walking-motorcycle-vehicle (most pragmatic) scenario. Forty-five per cent (21.3 million people) and 87% (41.6 million people) of Kenya’s population resided within 1-hour of the nearest urban centre for the least optimistic and most pragmatic scenarios respectively. Over 3.2 million people were considered marginalised or living outside the 2-hour threshold in the pragmatic scenario, 16.0 million Kenyans for walking only, and 2.2 million for the most optimistic scenario. County-level spatial access was highly heterogeneous ranging between 8%-100% and 32%-100% of people within the 1-hour threshold for the least and most optimistic scenarios, respectively. Counties in northern and eastern parts of Kenya were generally most marginalised. The correlation coefficients for nine SDG indicators ranged between 0.45 to 0.78 and were statistically significant.

Conclusion
Travel time to urban centres in Kenya is heterogeneous. Therefore, marginalised populations should be prioritised during resource allocation and policies should be formulated to enhance equitable access to public services and opportunities in urban areas.
The safety of nintedanib for the treatment of interstitial lung disease: A systematic review and meta-analysis of randomized controlled trials
Authors: Chen Chao-Hsien , Lin Hui-Chuan , Wang Ya-Hui , Wang Cheng-Yi , Lin You Shuei , Lai Chih-Cheng 
Published: May 2021

Introduction
Nintedanib can inhibit processes involved in the progression of fibrosis and can reduce the decline in forced vital capacity in patients with idiopathic pulmonary fibrosis (IPF) and fibrotic-interstitial lung disease (fibrotic-ILDs). Although the adverse events associated with nintedanib in IPF patients are well known, its safety in other fibrotic-ILD patients remained unclear.

Methods
We searched PubMed, EMBASE, Cochrane CENTRAL and Cochrane CDSR for randomized controlled studies which compared nintedanib with a placebo in ILD patients. We estimated pooled odds ratios (ORs) and 95% confidence intervals (CIs) for adverse events using the DerSimonian–Laird random-effects model.

Results
Six studies with a total of 2,583 patients were included in the meta-analysis. The pooled estimates showed that patients treated with nintedanib had a significantly higher likelihood of having any adverse events (OR = 2.39; 95% CI = 1.71–3.36) or adverse events leading to treatment discontinuation (OR = 1.73; 95% CI = 1.34–2.25). However, they had trend to lower likelihood of having fatal adverse events (OR = 0.69; 95% CI = 0.41–1.14) compared with the placebo group. Use of nintedanib was positively associated with diarrhea (OR = 5.96; 95% CI = 4.35–8.16), nausea (OR = 3.00; 95% CI = 1.93–4.66), vomiting (OR = 3.22; 95% CI = 2.17–4.76) and weight loss (OR = 3.38; 95% CI = 1.1.76–6.47). Whereas, patients treated with nintedanib were less likely to have a cough (OR = 0.73; 95% CI = 0.56–0.96) and dyspnea (OR = 0.70; 95% CI = 0.53–0.94).

Conclusions
Compared to a placebo, nintedanib was associated with a higher risk of adverse events, especially for diarrhea, nausea, vomiting and weight loss, but it was also associated with a lower risk of cough and dyspnea in IPF and fibrotic-ILD patients.
Incidence and predictors of mortality within the first year of antiretroviral therapy initiation at Debre-Markos Referral Hospital, Northwest Ethiopia: A retrospective follow up study
Authors: Aemro Agazhe , Wassie Mulugeta , Chekol Basazinew 
Published: May 2021

Background
Acquired Immunodeficiency Syndrome (AIDS) is one of the most fatal infectious diseases in the world, especially in Sub-Saharan Africa, including Ethiopia. Even though Antiretroviral therapy (ART) significantly decreases mortality overall, death rates are still highest especially in the first year of ART initiation.

Objective
To assess the incidence and predictors of mortality within the first year of ART initiation among adults on ART at Debre-Markos Referral Hospital, Northwest Ethiopia.

Methods
A retrospective follow-up study was conducted among 514 newly enrolled adults to ART from 2014 to 2018 at Debre-Markos Referral Hospital. Patients’ chart number was selected from the computer using a simple random sampling technique. Data were entered into EPI- INFO 7.2.2.6 and analyzed using Stata 14.0. The mortality rate within the first year was computed and described using frequency tables. Both bivariable and multivariable Cox-proportional hazard models were fitted to show predictors of early mortality.

Results
Out of 494 patient records included in the analysis, a total of 54 deaths were recorded within one year follow-up period. The overall mortality rate within 398.37 person years (PY) was 13.56 deaths/100 PY with the higher rate observed within the first three months. After adjustment, rural residence (Adjusted Hazard Ratio (AHR) = 1.97; 95% CI: 1.05–3.71), ≥ 6 months pre-ART duration (AHR = 2.17; 95% CI: 1.24–3.79), ambulatory or bedridden functional status at enrolment (AHR = 2.18; 95% CI: 1.01–4.74), and didn’t take Cotrimoxazole preventive therapy (CPT) during follow-up (AHR = 1.88; 95% CI: 1.04–3.41) were associated with early mortality of adults on ART.

Conclusion
Mortality within the first year of ART initiation was high and rural residence, longer pre-Art duration, ambulatory or bedridden functional status and didn’t take CPT during follow-up were found to be independent predictors. Hence, giving special attention for patients from rural area and provision of CPT is crucial to reduce mortality.
Infliximab-Induced Acute Liver Failure in a Patient With Crohn's Disease Requiring Orthotopic Liver Transplantation
Authors: Mustafa Alikhan Muhammed , Mansoor Emad , Satyavada Sagarika , Greer Katarina , Xin Wei , Cohen Stanley , Cooper Gregory , Katz Jeffry 
Published: May 2021

ABSTRACT
Tumor necrosis factor-alpha inhibitors are not known to have significant liver toxicity; however, a few case reports state otherwise. We report the case of a 25-year-old man with Crohn's disease who was initiated on infliximab. The patient developed severe mixed hepatocellular and cholestatic liver injury that progressed into acute liver failure. Based on clinical history, laboratory findings, and histology, this was presumed because of the development of autoimmune hepatitis secondary to infliximab. He underwent liver transplantation. The mainstay of treatment in this rare condition involves steroid therapy and possible transplantation. Patients must then avoid anti–tumor necrosis factor-alpha therapy for life.
Combining Cyclosporine With Ustekinumab in Acute Severe Ulcerative Colitis
Authors: Shaffer Seth R. , Traboulsi Cindy , Krugliak Cleveland Noa , Rubin David T. 
Published: May 2021

ABSTRACT
We have demonstrated the effectiveness and safety of combining cyclosporine and vedolizumab to treat ulcerative colitis (UC). We present 2 cases of hospitalized acute severe UC who had failed therapy with antitumor necrosis factor and vedolizumab and were treated successfully with induction cyclosporine and safely bridged to ustekinumab maintenance therapy. Both patients have avoided colectomy. There were no adverse events. We propose this novel treatment combination in medically resistant acute severe UC.
New insights on Laminaria digitata ultrastructure through combined conventional chemical fixation and cryofixation
Authors: Katsaros Christos , Le Panse Sophie , Milne Gillian , Carrano Carl J. , Küpper Frithjof Christian 
Published: May 2021

Abstract
The objective of the present study is to examine the fine structure of vegetative cells of Laminaria digitata using both chemical fixation and cryofixation. Laminaria digitata was chosen due to its importance as a model organism in a wide range of biological studies, as a keystone species on rocky shores of the North Atlantic, its use of iodide as a unique inorganic antioxidant, and its significance as a raw material for the production of alginate. Details of the fine structural features of vegetative cells are described, with particular emphasis on the differences between the two methods used, i.e. conventional chemical fixation and freeze-fixation. The general structure of the cells was similar to that already described, with minor differences between the different cell types. An intense activity of the Golgi system was found associated with the thick external cell wall, with large dictyosomes from which numerous vesicles and cisternae are released. An interesting type of cisternae was found in the cryofixed material, which was not visible with the chemical fixation. These are elongated structures, in sections appearing tubule-like, close to the external cell wall or to young internal walls. An increased number of these structures was observed near the plasmodesmata of the pit fields. They are similar to the “flat cisternae” found associated with the forming cytokinetic diaphragm of brown algae. Their possible role is discussed. The new findings of this work underline the importance of such combined studies which reveal new data not known until now using the old conventional methods. The main conclusion of the present study is that cryofixation is the method of choice for studying Laminaria cytology by transmission electron microscopy.
Instructor Presence in a Virtual Classroom
Authors: Tyrväinen Heli , Uotinen Sanna , Valkonen Leena 
Published: May 2021

Abstract
Synchronous online learning platforms have been used actively during the COVID-19 period. They have opened possibilities for online learning and interaction, but have also posed new challenges for instructors. This article provides insights into one teacher’s interactions and examines how the instructor presence is expressed in the teachers’ activities in virtual classrooms in higher education. Instructor presence is investigated using the social and teaching presence indicators of the community of inquiry (CoI) framework. Twelve hours of interactions across six online classes were recorded, transcribed, and analysed using content analysis. The findings suggest that indicators of teaching presence dominate interactions in a virtual classroom, but it often involves co-occurrences of indicators of social presence. The typical features of instructor presence included addressing students by name, encouraging them, expressing gratitude for and acknowledging their contributions, describing actions on the dashboard, clarifying and summarising content, and responding to technical concerns. These findings may suggest holistic and pedagogical ways to understand and develop synchronous online interactions and teaching and learning practices. They also have implications for the skills instructors need in virtual classrooms.
Improved chemical pulping and saccharification of a natural mulberry mutant deficient in cinnamyl alcohol dehydrogenase
Authors: Ikeda Tsutomu , Takata Naoki , Sakamoto Shingo , Hu Shi , Nuoendagula  , Hishiyama Shojiro , Mitsuda Nobutaka , Boerjan Wout , Ralph John , Kajita Shinya 
Published: May 2021

Abstract
Lignin content and its molecular structure influence various wood characteristics. In this study, the anatomical and physicochemical properties of wood derived from a naturally occurring mulberry mutant deficient in cinnamyl alcohol dehydrogenase (CAD), a key enzyme in lignin biosynthesis, were analyzed using conventional staining assays on stem sections, length and width measurements of xylem fiber cells, wood pulping and saccharification assays, and sugar compositional analysis of extractive-free wood powder. The present data indicate that the mutation in the CAD gene leads to improved wood delignification efficiency, increased pulp yield under alkaline pulping conditions, and enhanced saccharification efficiency following alkaline pretreatment. This study opens up new avenues for the multipurpose use of the mulberry CAD-deficient mutant as a raw material for biorefinery processes, in addition to its traditional use as a favored feed for silkworms.
Unification of functional annotation descriptions using text mining
Authors: Queirós Pedro , Novikova Polina , Wilmes Paul , May Patrick 
Published: May 2021

Abstract
A common approach to genome annotation involves the use of homology-based tools for the prediction of the functional role of proteins. The quality of functional annotations is dependent on the reference data used, as such, choosing the appropriate sources is crucial. Unfortunately, no single reference data source can be universally considered the gold standard, thus using multiple references could potentially increase annotation quality and coverage. However, this comes with challenges, particularly due to the introduction of redundant and exclusive annotations. Through text mining it is possible to identify highly similar functional descriptions, thus strengthening the confidence of the final protein functional annotation and providing a redundancy-free output. Here we present UniFunc, a text mining approach that is able to detect similar functional descriptions with high precision. UniFunc was built as a small module and can be independently used or integrated into protein function annotation pipelines. By removing the need to individually analyse and compare annotation results, UniFunc streamlines the complementary use of multiple reference datasets.
Characteristics of gluten-free potato dough and bread with different potato starch-protein ratios
Authors: Gao Jingyan , Wang Nan , Wang Lei , Song Shuang , Liu Miao , Wen Chengrong 
Published: May 2021

Abstract
The poor retention of fermentation gases and air is a critical issue for gluten-free (GF) products. To better understand the effect of potato flour on the characteristics of GF bread, the mechanistic relations between potato starch and potato protein in different ratios at 9:1, 8:2, 7:3, 6:4 and 5:5 for GF dough were investigated for viscoelasticity, thermal properties, moisture, microstructures, and bread quality. The results reveal that potato starch had a relatively important role in both dough and bread. The viscous character of dough was highest at a proportion of 6:4, with a more compact microstructure and better bread color, volume, hardness, chewiness, resilience and springiness. With decreasing starch content, the gelatinization and retrogradation enthalpy decreased, and the relaxation time of immobilized water and free water increased significantly. These results are believed to be helpful for processors to develop and optimize GF breads with potato starch and potato protein.
Synthesis of a Flame Retardant for Epoxy Resins: Thermal Stability, Flame Retardancy, and Flame-Retardant Modes
Authors: Zhang Y. , Liu J. , Li S. 
Published: May 2021

Abstract
A polyphosphonate (PDPA) flame retardant that contains phenyl phosphonic dichloride and 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide groups, has been synthesized. The flame retardant was introduced into epoxy resins (EP) and cured by 4,4’-diamino diphenylmethane. The vertical burning, limited-oxygen index and cone calorimeter tests reveal that the PDPA can enhance the flame-retardant properties of the EP significantly. With only a 4 wt% PDPA loading, the EP composites achieved a limited-oxygen index value of 33.4% and a V-0 rating in the vertical burning test, and the peak heat release rate and total heat release were decreased by 40.9% and 24.6%, respectively. The thermal properties and gas pyrolysis products of the EP composites were evaluated by thermogravimetric analysis and thermogravimetric analysis-Fourier transform infrared spectroscopy, and the morphology and structure of residual char were characterized by scanning electron microscopy, Flourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. To explain the combined effects of the condensed and gas phases, modes of the flame-retardant action are proposed.
A Comparative Fatigue Analysis of GFRP, CFRP and Structural Steel for Connecting Rod Using ANSYS
Authors: Cihan Ö. , Bulut M. 
Published: May 2021

Abstract
The connecting rod, as an important part in internal combustion engines, has been most widely used in automotive industry, and its main function is to transfer the reciprocating motion of the piston into the rotatory motion of the crankshaft. In this study, fatigue analysis of the connecting rod is performed numerically for different engine speeds. With this aim, it is attempted to reduce the weight of the connecting rod by choosing the low density and high strength of GFRP and CFRP composite materials instead of structural steel. In this way, it is possible to improve the engine efficiency with saving unnecessary balancing weights as well as reducing the cost of the connecting rod. In the current study, the connecting rod was modeled using Solidworks software, and its CAD model was transferred to the ANSYS/Workbench software for Finite Element Analyses (FEA). In FEA, fatigue analyses were performed to determine fatigue parameters such as alternating stress, deformation, fatigue life and safety factor according to Soderberg’s fatigue model. Results from this study showed that alternating stress and safety factor reached a critical value between piston pin end and crank end near to the piston pin end. Alternating stress values of the GFRP and CFRP connecting rods were much lower than those of structural steel rod. In contrast to reduction of the weight by 1/5, fatigue life of the connecting rod with structural steel material was much greater than those of GFRP and CFRP providing a higher safety factor compared with composite materials.
Ayurvedic management of female infertility due to tubal blockage
Authors: Otta Susmita Priyadarshinee , Reddy R. Govind , Sangvikar Sangeeta , Tripathy Rabinarayan 
Published: May 2021

Abstract

Objectives
Secondary Infertility is a major concern worldwide, accounting for about 40% of female infertility due to lifestyle factor. Secondary Infertility is having a close proximity to a disorder Vandhyatwa explained in Ayurvedic classics, due to a variety of causes. Several Ayurvedic interventions are advised such as Panchakarma (∼purification therapy) for vitiated Doshas in female reproductive organs, Snehapana (∼oral intake of medicated oil) followed by Virechana (∼purgation) to produce quality ovum. Other internal medications like Phalaghrita, Ashokarishta, Kanchanara guggulu etc. have a probable mode of action with enhancing the perceptibility of endometrium for implantation. Correlating fallopian tubes with the Artavavaha Srotas, its block is compared with the Sanga Srotodushti (obstructive pathology occurring in channels)of this Srotas. By virtue of the purification therapy and internal medication working synergistically might remove the Srotodustht.

Case presentation
A 30 year old female with a history of eight years post marital infertility was treated with Panchakarma along with Ayurvedic medicines after being diagnosed as infertility due to tubal blockage for a period of 16 weeks.

Conclusions
After 16 weeks of treatment, she reported with amenorrhoea and found Urine Pregnancy Test positive. Subsequently, confirmed the pregnancy by USG, as single live intrauterine foetus of Sonic Gestational Age – 8 weeks 5 days.
Monetary Policy Dynamics in the United States
Authors: Shodipe Oladimeji T. , Shobande Olatunji Abdul 
Published: May 2021

AbstractThe recognised approach to designing an optimal monetary policy model is based on the central bank’s ability to mitigate losses using a quadratic criterion subject to the linear structure of the economy. This study examines the United States Federal Reserve’s (Fed) monetary policy in different economic environments. It provides an empirical solution to the central bank’s optimisation problem when preferences are asymmetric in both in˛ation and output gaps. The study tested for structural breaks and uncovered potential evidence of nonlinearities in the Fed’s reaction function, which provides more information on policy objective. The empirical evidence suggests that the Fed’s policy rate differs in these periods. This strongly indicates the presence of asymmetry. Further evidence suggests that the predictive power of the estimated model increases when a smoothing process is allowed.
The prevalence of aflatoxin M1 (AFM1) in conventional and industrial dairy products (yogurt, cheese, kashk and dough) of Iran: a systematic review and meta-analysis
Authors: Makhdoumi Pouran , Hossini Hooshyar , Mohammadi Reza , Limoee Mojtaba 
Published: May 2021

Abstract
Aflatoxin is a toxic metabolite produced mainly by Aspergillus spp. which may occur in dairy products because of biotransformation. In this work, a systematic and meta-analysis approach has been considered on the topic of aflatoxin M1 (AFM1) content in dairy Iranian products. Based on the literature review, AFM1 was the most common aflatoxin contamination in dairy product. Additionally, studies revealed that higher levels of AFM1 were produced during cold seasons includes winter and autumn. Although, immunochemical technique (ELISA) was the frequent and rapid test, thin-layer chromatography (TLC) and chromatographic methods (HPLC) were commonly used as confirmative techniques to determine the level of aflatoxin. Meta-analyzing of the results showed that AFM1 can be found in the dairy products with overall prevalence percentage of 63.53 (95% confidence interval [CI]: 56.28–70.78) and 54.05 (95% CI: 43.09–65.02) based on the sample type and production process, respectively. The higher prevalence percentage of AFM1 of 73.96 (95% CI: 60.27–87.66) and 69.91 (95% CI: 62.00–78.83) was found in yoghurt and industrial production type of samples, respectively. In general, 17.8% of cheese, 14% of yogurt, 12.63% of kashk, and 2.1% of doogh contained AFM1 in concentrations exceeding the permitted level of standards. Totally, results showed that 88.89% of dairy products were contaminated by AFM1 exceeding from standard limits.