bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinico‐biological features and outcome of patients with splenic marginal zone lymphoma with histological transformation
Authors: Bastidas‐Mora Gabriela , Beà Sílvia , Navarro Alba , Gine Eva , Costa Dolors , Delgado Julio , Baumann Tycho , Magnano Laura , Rivas‐Delgado Alfredo , Villamor Neus , Colomer Dolors , Lopez-Guerra Mónica , Rozman María , Balagué Olga , Martínez Daniel , Baptista Maria Joao , Escoda Lourdes , Alcoceba Miguel , Blanes Margarita , Climent Fina , Campo Elías , Wotherspoon Andrew , López-Guillermo Armando , Matutes Estella 
Published: September 2021

SummaryWe describe 36 patients with splenic marginal zone lymphoma (SMZL) with transformation (SMZL‐T), including 15 from a series of 84 patients with SMZL diagnosed at the Hospital Clinic of Barcelona (HCB) and 21 diagnosed with SMZL‐T in other centres. In the HCB cohort, the cumulative incidence of transformation at 5 years was 15%. Predictors for transformation were cytopenias, hypoalbuminaemia, complex karyotype (CK) and both the Intergruppo Italiano Linfomi (ILL) and simplified Haemoglobin, Platelet count, lactate dehydrogenase (LDH) and extrahilar Lymphadenopathy (HPLL)/ABC scores (P < 0·05). The only independent predictor for transformation in multivariate analysis was CK [hazard ratio (HR) 4·025, P = 0·05]. Patients with SMZL‐T had a significantly higher risk of death than the remainder (HR 3·89, P < 0·001). Of the 36 patients with SMZL‐T, one developed Hodgkin lymphoma and 35 a diffuse large B‐cell lymphoma, 71% with a non‐germinal centre phenotype. The main features were B symptoms, lymphadenopathy, and high serum LDH. CK was observed in 12/22 (55%) SMZL‐T and fluorescence in situ hybridisation detected abnormalities of MYC proto‐oncogene, basic helix‐loop‐helix transcription factor (MYC), B‐cell leukaemia/lymphoma 2 (BCL2) and/or BCL6 in six of 14 (43%). In all, 21 patients received immunochemotherapy, six chemotherapy, one radiotherapy and three splenectomy. The complete response (CR) rate was 61% and the median survival from transformation was 4·92 years. Predictors for a worse survival in multivariate analysis were high‐risk International Prognostic Index (HR 5·294, P = 0·016) and lack of CR (HR 2·67, P < 0·001).
Historical biogeography of the Gondwanan freshwater genus Boeckella (Crustacea): Timing and modes of speciation in the Southern Hemisphere
Authors: Maturana Claudia S. , Rosenfeld Sebastián , Biersma Elisabeth M. , Segovia Nicolás I. , González‐Wevar Claudio A. , Díaz Angie , Naretto Javier , Duggan Ian C. , Hogg Ian D. , Poulin Elie , Convey Peter , Jackson Jennifer A. 
Published: September 2021

AbstractAimWe investigated evolutionary relationships and biogeographical patterns within the genus Boeckella to evaluate (1) whether its current widespread distribution in the Southern Hemisphere is due to recent long‐distance dispersal or long‐term diversification; and (2) the age and origin of sub‐Antarctic and Antarctic Boeckella species, with particular focus on the most widely distributed species: Boeckella poppei.LocationSouth America, sub‐Antarctic islands, maritime Antarctica, continental Antarctica and Australasia.MethodsTo reconstruct phylogenetic patterns of Boeckella, we used molecular sequence data collected from 12 regions and applied Bayesian and Maximum Likelihood analyses using multiple loci. We also estimated divergence times and reconstructed ancestral ranges using two different models of species evolution.ResultsPhylogenetic analyses and divergence time estimates suggested that Boeckella originated on the Gondwanan supercontinent and initially split into two main clades during the late Cretaceous (ca. 80 Ma). The first clade diversified in Australasia, and the second clade is currently distributed in South America, various sub‐Antarctic islands and Antarctica. Dispersal from South America to the Kerguelen and Crozet archipelagos occurred during the Eocene/Oligocene (B. vallentini) and in the late Pliocene (B. brevicaudata), while South Georgia and the maritime Antarctic were likely colonized during the late Pleistocene (B. poppei).Main conclusionsBoeckella has a Gondwanan origin, with further diversifications after the physical separation of the continental landmasses. Extant populations of Boeckella from the Scotia Arc islands and Antarctic Peninsula originated from South America during the Pleistocene, suggesting that original Antarctic Gondwanan lineages did not survive repeated glacial cycles during the Quaternary ice ages. A continuous decline in the species accumulation rate is apparent within the genus as the early Eocene, suggesting that Boeckella diversification may have decreased due to progressive cooling throughout the Cenozoic era.
Understanding the place for GLP‐1RA therapy: Translating guidelines for treatment of type 2 diabetes into everyday clinical practice and patient selection
Authors: Andreasen Christine Rode , Andersen Andreas , Knop Filip Krag , Vilsbøll Tina 
Published: September 2021

AbstractSince the first glucagon‐like peptide 1 (GLP‐1) receptor agonist (GLP‐1RA) was approved in 2005 (exenatide twice daily) for type 2 diabetes (T2D), the class has developed with newer compounds having more pronounced effects on glycaemic control and body weight. Also, administration regimes have become more convenient with once weekly injections, and recently an oral administration has become available. Large‐scale randomized controlled cardiovascular (CV) outcome trials (CVOTs) have shown that GLP‐1RA therapy can reduce the risk of CV disease (CVD) in high‐risk individuals with T2D. In addition, GLP‐1RAs may have renal benefits driven by new‐onset macroalbuminuria, although no effect on hard renal endpoints has been found. Subsequently, the place for GLP‐1RA therapy has changed over recent years, with most societies endorsing GLP‐1RA therapy in patients with established or high risk of CVD independently of glycaemia. Initiation of GLP‐1RA therapy can be complex due to differences in efficacy, side effects and safety profiles as well as administration forms within the class. Implementing guideline recommendations into ideal patient selection may be challenging both in specialty and non‐specialty settings. To ensure adequate and proactive use of modern glucose‐lowering medications in the treatment of T2D, it is essential to recognize patients with high risk or documented CVD. The present review provides an overview of the efficacy and benefits of the currently available GLP‐1RA compounds. Furthermore, we review the results from recent large‐scale CVOTs in a clinical context and suggest improving the implementation of GLP‐1RA therapy across specialties to improve overall patient selection.
The impact of COVID‐19 pandemic on student performance and self‐evaluation in preclinical operative dentistry
Authors: Inoue Natalie , Aldosari Muath , Park Sang E. , Ohyama Hiroe 
Published: September 2021

AbstractIntroductionDuring the COVID‐19 pandemic, dental schools were required to reformat their curricula to accommodate regulations mandated to protect the health of students and faculty. For students enrolled in the Operative Dentistry preclinical courses at the Harvard School of Dental Medicine (HSDM), this modified curriculum included frontloading the course with lectures delivered remotely, followed by in‐person laboratory exercises of learned concepts. The aim of this article was to determine the impact that the modifications had on student performance and student self‐evaluation capabilities.Materials and methodsThirty‐eight students were introduced to this restructured course. Their performance in a final multiple‐choice (MC) examination, four preclinical laboratory competency assessments (class II amalgam preparation and restoration, class III composite preparation and restoration) and their self‐assessment of these preclinical competency assessments were then compared with the pre‐COVID pandemic (P‐CP) classes from years 2014 to 2019 (n = 216 students). Linear regressions were performed to determine differences in mean faculty scores, self‐assessment scores, student‐faculty score gaps (S‐F gaps) and absolute S‐F gaps seen between the class impacted by the pandemic and the P‐CP classes.ResultsThe results demonstrated that students during the COVID‐19 pandemic (D‐CP) had a higher average faculty score in all four preclinical laboratory competency assessments and in the final MC examination. In addition, the S‐F gap was smaller in this cohort as compared with the P‐CP classes.ConclusionDespite the challenges of restructuring the preclinical curricula, D‐CP students performed better than their P‐CP predecessors in multiple facets of this Operative Dentistry course including self‐assessment accuracy.
Insider lobbying and government contracts: The moderating role of firm size
Authors: Alonso José M. , Andrews Rhys 
Published: September 2021

AbstractThis study examines insider lobbying as a form of relational Corporate Political Activity (CPA) that can be used by firms to gain an advantage in the competition for government contracts, and how firm size moderates the effectiveness of different insider lobbying strategies. Drawing on a unique dataset that captures meetings between private companies and British government ministers, we find that both the breadth and depth of insider lobbying are positively related to the value of the contracts awarded by the UK Ministry of Defence. Further analysis reveals that the benefits from a strategy of lobbying depth are stronger for small firms, than those from a strategy of lobbying breadth. The findings suggest that the bridging and bonding social capital cultivated through meetings with politicians can be deployed in alternative ways by different‐sized firms.
Data‐poor stock assessment of fish stocks co‐exploited by commercial and recreational fisheries: Applications to pike Esox lucius in the western Baltic Sea
Authors: van Gemert Rob , Koemle Dieter , Winkler Helmut , Arlinghaus Robert 
Published: September 2021

AbstractInformation on catch and effort of recreational angling in mixed‐use fisheries (co‐exploited by commercial and recreational fishers) is often scarce, preventing the application of data‐rich stock assessments typically performed for industrialised commercial fisheries. This study shows how data‐poor stock assessment methods developed for marine fisheries, particularly a model class labelled as “catch‐only” models (COMs), offer a possible solution. As a case study, COMs are used to assess a northern pike Esox lucius L. stock around the German Baltic island of Rügen. Multiple COMs were fitted to a time series of total pike removals, and their outputs were used as explanatory variables in ensemble models. The stock was found to be fully exploited and currently declining. This study highlights the potential for using COMs to determine status of previously unassessed coastal and freshwater stocks facing recreational fishing pressure and demonstrates how incorporating recreational removals is crucial for achieving reliable insights into the status of mixed‐use stocks.
Lowered nutritional quality of plankton caused by global environmental changes
Authors: Lau Danny C. P. , Jonsson Anders , Isles Peter D. F. , Creed Irena F. , Bergström Ann‑Kristin 
Published: September 2021

AbstractGlobal environmental changes are causing widespread nutrient depletion, declines in the ratio of dissolved inorganic nitrogen (N) to total phosphorus (DIN:TP), and increases in both water temperature and terrestrial colored dissolved organic carbon (DOC) concentration (browning) in high‐latitude northern lakes. Declining lake DIN:TP, warming, and browning alter the nutrient limitation regime and biomass of phytoplankton, but how these stressors together affect the nutritional quality in terms of polyunsaturated fatty acid (PUFA) contents of the pelagic food web components remains unknown. We assessed the fatty acid compositions of seston and zooplankton in 33 lakes across south‐to‐north and boreal‐to‐subarctic gradients in Sweden. Data showed higher lake DIN:TP in the south than in the north, and that boreal lakes were warmer and browner than subarctic lakes. Lake DIN:TP strongly affected the PUFA contents—especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—in seston, calanoids, and copepods (as a group), but not in cladocerans. The EPA+DHA contents increased by 123% in seston, 197% in calanoids, and 230% in copepods across a lake molar DIN:TP gradient from 0.17 to 14.53, indicating lower seston and copepod nutritional quality in the more N‐limited lakes (those with lower DIN:TP). Water temperature affected EPA+DHA contents of zooplankton, especially cladocerans, but not seston. Cladoceran EPA+DHA contents were reduced by ca. 6% for every 1°C increase in surface water. Also, the EPA, DHA, or EPA+DHA contents of Bosmina, cyclopoids, and copepods increased in lakes with higher DOC concentrations or aromaticity. Our findings indicate that zooplankton food quality for higher consumers will decrease with warming alone (for cladocerans) or in combination with declining lake DIN:TP (for copepods), but impacts of these stressors are moderated by lake browning. Global environmental changes that drive northern lakes toward more N‐limited, warmer, and browner conditions will reduce PUFA availability and nutritional quality of the pelagic food web components.
Changes in Deep Groundwater Flow Patterns Related to Oil and Gas Activities
Authors: Jellicoe Keegan , McIntosh Jennifer C. , Ferguson Grant 
Published: September 2021

AbstractLarge volumes of saline formation water are both produced from and injected into sedimentary basins as a by‐product of oil and gas production. Despite this, the location of production and injection wells has not been studied in detail at the regional scale and the effects on deep groundwater flow patterns (i.e., below the base of groundwater protection) possibly driving fluid flow toward shallow aquifers remain uncertain. Even where injection and production volumes are equal at the basin scale, local changes in hydraulic head can occur due to the distribution of production and injection wells. In the Canadian portion of the Williston Basin, over 4.6 × 109 m3 of water has been co‐produced with 5.4 × 108 m3 of oil, and over 5.5 × 109 m3 of water has been injected into the subsurface for salt water disposal or enhanced oil recovery. Despite approximately equal values of produced and injected fluids at the sedimentary basin scale over the history of development, cumulative fluid deficits and surpluses per unit area in excess of a few 100 mm are present at scales of a few 100 km2. Fluid fluxes associated with oil and gas activities since 1950 likely exceed background groundwater fluxes in these areas. Modeled pressures capable of creating upward hydraulic gradients are predicted for the Midale Member and Mannville Group, two of the strata with the highest amounts of injection in the study area. This could lead to upward leakage of fluids if permeable pathways, such as leaky wells, are present.
Chemical composition of alkaline‐pretreated sugarcane bagasse and its effects on the physicochemical characteristics of fat‐replaced sausage
Authors: Sompugdee Chokchai , Quan Vo Minh , Sriroth Klanarong , Sukyai Prakit 
Published: September 2021

AbstractThe potential of cellulose from sugarcane bagasse used for pork sausage was investigated. The purity level of cellulose fibre from sugarcane bagasse and the functional characteristics in pork sausage were studied. The differences in the sugarcane fibre and sausage characteristics were strongly related to the cellulose/lignin content of the extracted cellulose under different amounts of bleaching. Bleached sugarcane fibres showed better water (3.55) and oil (2.34) holding capacity in comparison with untreated fibre (2.92 and 2.38, respectively). The sugarcane fibres in each treatment stage showed different effects on sausage properties. Sausages with 1% cellulose fibres added had an improved texture profile, but the addition of 3% cellulose fibres to sausages resulted in a higher cooking yield. Consumers considered the sensory characteristics of all sausages as acceptable. These results indicated that low levels of cellulose extracted from sugarcane bagasse could be added and maintain the inherent characteristics of meat products.
Physicochemical stability of antilisterial proteins from P. polymyxa Kp10 as potential food biopreservative
Authors: Mokhtar Nur Fadhilah Khairil , Hashim Amalia Mohd , Abbasiliasi Sahar , Zulkarnain Aisyah , Raja Nhari Raja Mohd Hafidz , Ariff Arbakariya , Mustafa Shuhaimi , Abdul Rahim Raha 
Published: September 2021

AbstractListeria monocytogenes has continuously become a significant threat to consumers worldwide. The use of chemical‐derived preservatives that are commonly associated with safety and nutritional issues has prompted the use of natural‐based preservatives as a better alternative. Many bacterial strains including Paenibacillus polymyxa Kp10 have been reported to produce various antimicrobial proteins and compounds that are considered more natural. However, their stability in various physicochemical conditions should be examined before being applied in various types of food. In this study, the stability of four previously identified antilisterial proteins in P. polymyxa Kp10 upon exposure to several physicochemical conditions was examined. More than 80% residual antilisterial activity is conserved upon heat and proteinase K treatment. But, sensitivity to 24 h trypsin digestion has been observed. P1 and P2 proteins (histone‐like DNA binding proteins HU) were sensitive to alkaline pH (pH 10‐12) as compared with other proteins. More than 70% and 97% residual antilisterial activity were recovered after incubation in raw beef homogenates and simulated meat gravy model, respectively. However, the antilisterial activity of most proteins was highly compromised in chicken and salmon meat homogenates, and UHT cow milk. Inoculation of these proteins into Listeria‐contaminated simulated meat gravy showed that all proteins exerted a bactericidal action against L. monocytogenes. P1 and P2 shared almost similar antilisterial activity rates, while P4 was the most potent antilisterial protein. The findings in this study could provide important preliminary data for future applications of these proteins as preservative in food products especially beef‐based meat products.
Interaction of the human intestinal microbiota with the release of bound phenolic compounds in chickpea (Cicer arietinum L.)
Authors: Perez‐Perez Liliana Maribel , Huerta‐Ocampo José Ángel , Ramos‐Enríquez José Rogelio , Ruiz‐Cruz Saúl , Wong‐Corral Francisco Javier , Rosas‐Burgos Ema Carina , Hernández‐Ortíz Magdalena , Encarnación‐Guevara Sergio , Robles‐García Miguel Angel , Iturralde‐García Rey David , Borboa‐Flores Jesús , Del‐Toro‐Sánchez Carmen Lizette 
Published: September 2021

SummaryThe objective of this work was to release bound phenolic compounds (PC) from chickpea by the interaction of the microbiota of a volunteer and to identify the enzymes implied to deliver these PC. The highest amount of PC was released at 12 and 24 h (16.8–18.5 mg GAE/g). Higher antioxidant capacity was observed in these hours through 2,20‐azino‐bis‐(3ethylbenzothiazoline‐6‐sulfonic acid), 2,2‐diphenyl‐1‐picrylhydrazyl, ferric reducing antioxidant power and 2,´2.Azobis (2 methylpropionamidine) techniques. Escherichia, Klebsiella, Bacteroides and Veillonella were some genera identified in the microbiota implied in delivered PC. The principal PC identified by ultra performance liquid chromatography–mass spectrometry were flavonoids. Proteomic analysis identified hundreds of proteins from the intestinal microbiota after 12 h of fermentation, including enzymes related to the release of bound PC from chickpea such as pectin esterase. Therefore, this enzyme could be used in other food sources for the release of PC bound to the food matrix and thus take advantage of their bioactive benefits.
Effects of depression and social interaction on smartphone addiction among female adolescents
Authors: Lee Eun Jee , Kim Hyeon Ok 
Published: September 2021

AbstractPurposeThis study aimed to investigate the effect of social interaction and depression on smartphone addiction among Korean female adolescents.MethodsThis study is a secondary analysis of the data from the Korean Children and Youth Panel Survey, a national survey conducted by the National Youth Policy Institute In Korea in 2018. The data of 1185 female adolescents was analyzed. Binary logistic regression was performed between smartphone addiction and depression, parenting behavior, peer interaction and teacher interaction.FindingsProportion of risk users was 24.9%. Depression, coercive parenting attitude, negative peer relationship, and trust/sensitivity/accessibility in teacher relationship predicted smartphone addiction.ConclusionsThis study emphasizes the necessity of smartphone addiction prevention programs to lower depression levels and approach adolescents' parents, friends, and teachers.
Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis
Authors: Rudling Maja , Nyström Pär , Bölte Sven , Falck‐Ytter Terje 
Published: September 2021

BackgroundStudies of infants with an elevated likelihood of autism spectrum disorder can identify basic developmental processes that are associated with subsequently emerging clinical symptoms. Atypical responsiveness to sounds in infancy is such a potential early marker of autism. Here, we used pupillometry to quantify reactivity to social and nonsocial sounds in infants with a subsequent diagnosis. Previous research suggest that pupil dilation reflects attentional alerting, and link it to the locus coeruleus norepinephrine system.MethodsWe measured pupil dilation responses to child‐directed speech and the sound of running water; sounds infants often hear in their everyday life. The final sample consisted of 99 ten‐month‐old infants (52 girls), of whom 68 had an elevated likelihood of autism and 31 were typically developing low‐likelihood infants. At follow‐up (36 months of age), 18 children in the elevated‐likelihood group were diagnosed with autism.ResultsCompared to infants without diagnosis, the infants who were subsequently diagnosed with autism had larger pupil dilation when listening to nonsocial sounds, while reactivity to speech was strikingly similar between groups. In the total sample, more pupil dilation to the nonsocial sound was associated with higher levels of autistic symptoms. We also found that on a trial‐by‐trial basis, across all conditions and groups, more pupil dilation was associated with making fewer gaze shifts.ConclusionsThis study did not find evidence of atypical pupillary reactivity to child‐directed speech early in life in autism. Instead, the results suggest that certain nonsocial sounds elicit atypically strong alerting responses in infants with a subsequent autism diagnosis. These findings may have important theoretical and clinical implications.
Fire‐Sale Spillovers in Debt Markets
Authors: FALATO ANTONIO , HORTAÇSU ALI , LI DAN , SHIN CHAEHEE 
Published: September 2021

ABSTRACTFire sales induced by investor redemptions have powerful spillover effects among funds that hold the same assets, hurting peer funds' performance and flows, and leading to further asset sales with negative bond price impact. A one‐standard‐deviation increase in our fire‐sale spillover measure leads to a 45 (90) bp decrease in peer fund returns (flows) and a two percentage point increase in the likelihood of a large bond price drop. The results hold in a regression‐discontinuity design addressing identification concerns. Timing, heterogeneity, instrumental‐variable, and placebo tests further support the price‐impact mechanism. Model‐based counterfactual and stress‐test analyses quantify the financial stability implications.