bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oseltamivir improved thrombocytopenia during veno-arterial extracorporeal membrane oxygenation in adults with refractory cardiac failure: A single-center retrospective real-world study
Authors: Li Yuan , Wang Lin , Zhang Jianning , Han Hui , Liu Han , Li Chaoyang , Guo Haipeng , Chen Yuguo , Chen Xiaomei 
Published: February 2021

Abstract
Background

Severe thrombocytopenia is a common complication of extracorporeal membrane oxygenation (ECMO). Oseltamivir can be used to treat infection-associated thrombocytopenia.
Objective

To evaluate the effect of oseltamivir on attenuating severe thrombocytopenia during ECMO.
Methods

This was a single-center real-world study in critically ill patients supported with venous-arterial extracorporeal membrane oxygenation (VA-ECMO). Patients suspected or confirmed with influenza received oseltamivir according to the Chinese guidelines. Thrombocytopenia and survival were compared between the oseltamivir-treated and -untreated groups. The factors associated with survival were analyzed by multivariable Cox analysis.
Results

A total of 82 patients were included. All patients developed thrombocytopenia after initiating VA-ECMO. Twenty-three patients received oseltamivir (O+ group), and 59 did not (O− group). During the first 8 days of VA-ECMO initiation, the platelet counts in the O+ group were higher than in the O− group (all P < 0.05). The patients in the O+ group had higher median platelet counts at the nadir (77,000/µL, 6,000-169,000/µL), compared with the O− group (49,000/µL, 2,000-168,000/µL; P = 0.04). A platelet count nadir < 50,000/µL was seen in 26% of the patients in the O+ group, compared with 53% in the O− group (P = 0.031). No significant differences in survival to discharge were seen between the O+ and O− groups (48% vs. 56%, P = 0.508). Only the Sequential Organ Failure Assessment (SOFA) scores at the time of VA-ECMO initiation were independently associated with survival (OR = 1.12, 95% confidence interval (95% CI): 1.02–1.22, P = 0.015).
Conclusions

Oseltamivir could ameliorate VA-ECMO-related thrombocytopenia. These findings suggest the prophylactical potential of oseltamivir on severe thrombocytopenia associated with the initiation of VA-ECMO.
Impact of Alpha-Adrenergic Receptor Antagonists on outcomes in patients with heart failure. A post-hoc analysis using National Health Fund database
Authors: Symonides Bartosz , Lewandowski Jacek , Śliwczyński Andrzej 
Published: February 2021

Abstract
BackgroundThe alpha-adrenolytics (AA) are not recommended in patients with EF reduced heart failure due to safety concerns. The aim of our study was to assess the safety of AA in patients hospitalized due to exacerbation of HF and the influence of these drugs on long-term endpoints.MethodsData collected by the National Health Fund was used. Patients hospitalized due to HF exacerbation were included. The primary outcome was all-cause mortality and the secondary was the first readmission due to HF or all-cause death occurring more than 30 days after discharge.ResultsOf 140 668 patients hospitalized in the year 2013 n=53317 were included and followed for a median of 56.3 months. AA patients had lower long-term mortality (52.8% vs. 54.9%, unadjusted P=0.038). The treatment with AA positively and affected long-term survival (adjHR 0.82, 95%CI 0.78-0.87, P<0.001), as well as secondary endpoint (adjHR 0.85, 95%CI 0.81-0.90, P<0.001).Cox analysis in the subgroup treated with beta-blockers revealed that treatment with AA was associated with lower mortality (adjHR 0.82, 95%CI 0.75-0.90, P<0.001) and lower incidence of secondary endpoint (adjHR 0.85, 95%CI 0.78-0.92, P<0.001). ConclusionsIn compliant patients hospitalized due to HF exacerbation post discharge treatment with AA was safe and beneficial.
The Anxious-Depressive Attack Severity Scale: Development and Initial Validation and Reliability
Authors: Noda Shota , MATSUMOTO Satomi , KAWASAKI Naoko , MASAKI Mina , FUKUI Itaru , KAIYA Hisanobu 
Published: February 2021

Abstract
Background: Anxious-depressive attack (ADA) is a symptom complex that comprises sudden intense feelings of anxiety or depression, intrusive rumination of regretful memories or future worries, emotional distress due to painful thoughts, and coping behaviors to manage emotional distress. ADA has been observed transdiagnostically across various psychiatric disorders. Although the importance of ADA treatment has been indicated, a scale to measure the severity of ADA has not been developed. This study aimed to develop the Anxious-Depressive Attack Severity Scale (ADAS) for measuring the severity of ADA symptoms and examine its reliability and validity. Methods: A total of 242 outpatients responded to a questionnaire and participated in an interview, which were designed to measure the severity of ADA, depression, anxiety, anxious depression, and social anxiety symptoms. Based on the diagnostic criteria for ADA, 54 patients were confirmed to have ADA and were included in the main study analyses. Results: The results of the exploratory factor analysis showed that the ADAS had two factors: severity of ADA symptoms and ADA frequency and coping behaviors. McDonald's ωt coefficients were high for the overall scale and the first factor (ωt = .78 and ωt = .83, respectively) but low for the second factor (ωt = .49). The ADAS score was significantly positively correlated with clinical symptoms related to anxiety and depression.Conclusion: The present study demonstrated that the ADAS had sufficient reliability and validity; however, internal consistency was insufficient for the second factor. Overall, the ADAS has potential to be a valuable tool for use in clinical trials of ADA.
Acupuncture for Oculomotor Nerve Palsy: a Systematic Review Protocol
Authors: Zhang Xiaohui , Zheng Shumei , Liu Yijiang , Du Ruosang , Yuan Hongwen , Cui Hai 
Published: February 2021

Abstract
Background: Oculomotor nerve palsy(ONP) is a common clinical disease in neurology and ophthalmology which results in serious syndrome such as ptosis, diplopia, and limited eye movement. The major medications treating ONP usually make sense and side effects, while acupuncture is known as a safe and effective therapy for ONP. We aim to evaluate the safety and efficacy of acupuncture in the treatment of ONP.Methods: The following database will be required from PubMed, Cochrane Library, Medline, Chinese Biomedical Literature Database, China National Knowledge Infrastructure (CNKI), Wanfang data, Chinese Scientific Journal Database, including studies and published systematic review in the reference list and grey. Three reviewers will search these databases, select data and evaluate the quality of studies separately. The methodological quality will be measured by the Cochrane risk of bias tool. The Review Manager 5.3 will be used to synthesize collected data.Results: The systematic review will evaluate the safety and efficacy based on current evidence of acupuncture for ONP. The primary outcomes are the therapeutic efficiency, the sizes of palpebral fissure and pupil, the range of eye movement and scores of diplopia. Quality of life, and adverse effects will be assessed as secondary outcomes. Conclusion: The study will provide high-quality recently evidence for evaluating the efficacy of acupuncture for patients with ONP. PROSPERO registration number: CRD42020162140.
Malnutrition Affects Cholesterol Paradox in Coronary Artery Disease: a 41,229 Chinese Cohort Study
Authors: Wang Bo , Liu Jin , Chen Shiqun , Ying Ming , Chen Guanzhong , Liu Liwei , Lun Zhubin , Li Huanqiang , Huang Haozhang , Li Qiang , Yu Yaren , Lin Mengfei , Wei Wen , Huang Zhidong , Yang Yongquan , Chen Jiyan , Tan Ning , Liu Yong 
Published: February 2021

Abstract
Background: Several studies found that baseline low LDL-C concentration was associated with poor prognosis in patients with acute coronary syndrome (ACS), which was called “cholesterol paradox”. Low LDL-C concentration may reflect underlying malnutrition, which was strongly associated with increased mortality. We objected to investigate the cholesterol paradox in patients with CAD and the effects of malnutrition.Method: A total of 41,229 CAD patients admitted to Guangdong Provincial People's Hospital in China were included in this study from January 2007 to December 2018, and divided into two groups (LDL-C < 1.8 mmol/L, n=4,863; LDL-C ≥ 1.8 mmol/L, n = 36,366). We used Kaplan-Meier method and Cox regression analyses to assess the association between LDL-C levels and long-term all-cause mortality and the effect of malnutrition. Result: In this real-world cohort (mean age 62.94 years; 74.94% male), there were 5257 incidents of all-cause death during a median follow-up of 5.20 years [Inter-quartile range (IQR): 3.05-7.78 years]. Kaplan–Meier analysis showed that low LDL-C levels were associated with worse prognosis. After adjusting for baseline confounders (e.g., age, sex and comorbidities, etc.), multivariate Cox regression analysis revealed that low LDL-C level (<1.8mmol/L) was not significantly associated with all-cause mortality (adjusted HR, 1.04; 95% CI, 0.96-1.24). After adjustment of nutritional status, risk of all-cause mortality of patients with low LDL-C level decreased (adjusted HR, 0.90; 95% CI, 0.83-0.98). In the final multivariate Cox model, low LDL-C level was related to better prognosis (adjusted HR, 0.91; 95% CI, 0.84-0.99).Conclusion: Our results demonstrate that the cholesterol paradox persisted in CAD patients, but disappeared after accounting for the effects of malnutrition.
The use of A. mellifera drone's olfactory sensitivity towards pathological odours as a selection trait in the breeding against V. destructor
Authors: Ivanova Ivelina , Bienefeld Kaspar 
Published: February 2021

Abstract
The most effective strategy against brood diseases, such as infestation by the mite Varroa destructor, is the early detection and removal of sick brood. Recent findings suggest that genes associated with worker bees' olfactory perception play a central role in Varroa-sensitive hygiene (VSH). In the following approach, Apis mellifera drones' odour sensitivity was examined through a standardised Proboscis extension response (PER) test. Individuals with a positive/negative conditioning outcome to two parasitised-pupae extracts (extract-low and extract-high) were used for breeding. Twenty-one queens from a VSH selection line (SelQ) and nineteen queens from an unselected line (ConQ) were single-drone-inseminated with drones that showed either a positive (SenD+) or a negative (SenD-) PER test. Individual VSH behaviour of a total of 5072 offspring of these combinations (SelQ x SenD+, SelQ + x SenD-, ConQ x SenD+, ConQ x SenD-) was subsequently observed in a specially designed unit with infrared light. The results from the observation were also separately examined, considering the hygienic status of the participating queens and drones. The results of the PER test of the drones were not significantly reflected in the VSH results of the respective offspring. On the other hand, the participating queens/drones' hygienic status was crucial for the manifestation of VSH.
HOXC10 promotes growth and migration of melanoma by regulating Slug to activate the YAP/TAZ signaling pathway
Authors: Miao Yuanxin , Zhang Weina , Liu Su , Leng Xiangfeng , Hu Chunnan , Sun Hao 
Published: February 2021

Abstract
Homeobox C10 (HOXC10) has been reported to participate in various cancers. However, the involvement of HOXC10 in melanoma is still remains unknown. Here, we attempted to determine whether HOXC10 can affect the development of melanoma. We separated melanoma tissues and the matched tumor-adjacent normal tissues from melanoma patients, and examined HOXC10 expression in the melanoma cells and tissues. Comparing with the tumor-adjacent normal tissues, HOXC10 was up-regulated in melanoma tissues. Melanoma cells also displayed an up-regulation of HOXC10. Moreover, HOXC10 overexpression promoted cell proliferation, clone formation and inhibited apoptosis of melanoma cells. HOXC10 up-regulation also enhanced migration, invasion and epithelial-mesenchymal transition (EMT) in melanoma cells. Additionally, HOXC10 accelerated Slug expression by interacting with Slug, and activating the promoter of Slug. Slug activated the YAP/TAZ signaling pathway, which was reversed by HOXC10 silencing. The in vitro assays demonstrated that inhibition of HOXC10 significantly repressed tumor growth and lung metastasis of melanoma in mice by inhibiting Slug and YAP/TAZ signaling pathway. In conclusion, this work demonstrated that HOXC10 promoted growth and migration of melanoma by regulating Slug to activate the YAP/TAZ signaling pathway. Therefore, this study suggests that inhibition of HOXC10 has therapeutic potential in melanoma.
Complex rearrangement in acute myeloid leukemia M2 with RUNX1/RUNX1T1 fusion involving chromosomes 8, 17 and 21
Authors: Mishra Shiba Ranjan , Rawal Leena , Othman Moneeb A.K. , Thatai Atul , Sarkar Aditi , Lal Vandana , Bhattacharya Saurabh Kumar 
Published: February 2021

Abstract
BackgroundThe translocation t(8;21)(q22;q22) is one of the most frequent chromosomal abnormalities associated with acute myeloid leukemia (AML) sub type M2. About 3–5% of cases with additional chromosomal abnormalities, including structural and numerical ones, are reported to include a complex translocation t(8;21;N).Case PresentationHere we report a chromosome rearrangement observed in a 19 years-old female diagnosed with AML-M2. When subjected to (molecular) cytogenetic analyses a complex three-way translocation involving chromosomes 8, 17 and 21 was detected, forming not a t(8;21;17) as one would expect. Real time-polymerase chain reaction analysis using 6 AML specific markers showed the presence of RUNX1/RUNX1T1 fusion gene transcripts identical to those found in classical translocation t(8;21) coupled with presence of FLT3-ITD mutation identified by fragment analysis.ConclusionsThe present case highlights importance of complex rearrangements rarely encountered in AML, suggesting that all involved regions harbor critical candidate genes regulating the pathogenesis of AML, leading to novel as well as well-known leukemia associated chromosomal aberrations.
Dynamic analysis and experiment of QZS system with nonlinear hysteretic damping
Authors: Hu Xiaoying , Zhou Chunyan 
Published: February 2021

Abstract
Nonlinear Quasi-zero-stiffness (QZS) vibration isolation systems with linear damping cannot lead to displacement isolation with different excitation levels. In this study, a QZS system with nonlinear hysteretic damping was investigated. The Duffing-Ueda equation with a coupling nonlinear parameter 𝜂 was proposed to describe the dynamic motion of the QZS system. By using the harmonic balance method (HBM), the primary and secondary harmonic responses were obtained and verified by numerical simulations. The results indicated that nonlinear damping can guarantee a bounded response for different excitation levels. The one-third subharmonic response was found to affect the isolation frequency range even when the primary response was stable. To evaluate the performance of the QZS system, the effective isolation frequency Ω𝑒 and maximum transmissibility 𝑇𝑝 were proposed to represent the vibration isolation range and isolation effect, respectively. By discussing the effect of 𝜂 on Ω𝑒 and 𝑇𝑝, the conditions to avoid nonlinear phenomena and improve the isolation performance are provided. A prototype of the QZS system was then constructed for vibration tests, which verified the theoretical analysis.
Non-integrability of the Kepler and the two body problem on the Heisenberg group
Authors: Maciejewski Andrzej , Stachowiak Tomasz 
Published: February 2021

Abstract
The analog of the Kepler system defined on the Heisenberg group introduced by Montgomery and Shanbrom (2015) is integrable on the zero level of the Hamiltonian. We show that in all other cases the system is not Liouville integrable due to the lack of additional meromorphic first integrals. We prove that the analog of the two body problem on the Heisenberg group is not integrable in the Liouville sense.
Ethnic and Racial Differences in Adoption of Evidence-based Diabetes Prevention Strategies and Weight Loss Outcomes in a Shared Decision-Making Intervention
Authors: Castellon-Lopez Yelba , Duru O. Kenrik , Turk Norman , Moreno Gerardo , Norris Keith , Vu Amanda , Saju Rintu , Tseng Chi Hong , Skrine-Jeffers Kia , Mangione Carol , Frosch Dominick , Moin Tannaz 
Published: February 2021

Abstract
Background: To promote health equity, interventions should achieve similar clinical outcomes among all subgroups. However, evidence from real-world Diabetes Prevention Program (DPP) translation studies suggests that adoption of diabetes prevention strategies and weight loss outcomes may vary by race and ethnicity.Methods: In this retrospective analysis, we examined adoption of diabetes prevention strategies and weight change outcomes among participants who received a shared decision making (SDM) intervention as part of the Prediabetes Informed Decisions and Education (PRIDE) study. We compared (1) uptake of DPP and/or metformin and (2) percent weight change at 12 months stratified by race/ethnicity using generalized linear mixed effects models. Results: SDM participants (n=515) were on average 56 years old (SD=11.0) with HbA1c 6.0% (SD=.20) and BMI of 30.3 (SD=5.2) who self-identified as non-Hispanic White (NHW) (39.2%), non-Hispanic Asian/Pacific Islander (NHAPI) (18.4%), Hispanic (16.7%), or non-Hispanic Black (NHB) (14.4%). There were no significant differences in adoption of DPP and/or metformin between racial/ethnic groups. NHB and Hispanic participants lost significantly less weight at 12 months as compared to NHW participants (-1.0% and -1.2%, respectively, vs. -3.3%, both comparisons p<.01). Conclusion: While adoption of evidence-based options for diabetes prevention did not vary, Hispanics and NHB lost significantly less weight than NHW at 12-months follow-up after SDM. Minority groups have a higher risk of type 2 diabetes and racial/ethnic disparities in weight change outcomes after adoption of diabetes prevention strategies can further compound risk. These findings have important implications for ongoing efforts to augment diabetes prevention and health equity nationally.
Feasibility of a Nutrition and Lifestyle Focused Shared Medical Appointment Program in a Resource-Challenged Community Setting
Authors: Bharmal Nazleen , Beidelschies Michelle , Alejandro-Rodriguez Marilyn , Alejandro Kayla , Guo Ning , Jones Tawny , Bradley Elizabeth 
Published: February 2021

Abstract
Background: In order to address disparities in preventable chronic diseases, we adapted a nutrition and lifestyle focused shared medical appointment (SMA) program to be delivered in an underserved community setting. The objective was to determine the feasibility of the community-based SMA pilot.Methods: The SMA program was a community benefit for community residents regardless of their participation in the research study. We evaluated pre-post changes in wellness indices, biometrics, self-efficacy, and trust in medical researchers. To understand the barriers and facilitators for implementation and scalability, we conducted two participant focus groups and five stakeholder interviews and used content analysis to determine major themes. Key Results: Fifteen participants attended 10 weekly sessions. The majority were older adult, African American women. There were pre-post improvements in mean systolic (-10.5 [7.7] mmHg, p=0.0001) and diastolic (-4.7 [6.7] mmgHg, p=0.17) blood pressures and weight (-5.7 [6.3] pounds, p=0.0034) at 3 months though these were not significant at 6 months. More individuals reported improvements in health status, daily fruit and vegetable intake, and sleep than at baseline. There were no significant pre-post changes in other wellness indices, self-efficacy, trust in medical researchers, hemoglobin A1c, insulin, or LDL cholesterol. Participants discussed positive health changes as a result of the SMA program, program preferences, and facilitators and barriers to continuing program recommendations in focus groups. SMA implementation was facilitated by clinical staff who adjusted content to a low health literacy group and partnership with a trusted community partner. Sustainability barriers include heavy personnel time and in-kind resources to deliver the program. Conclusion: Lifestyle-focused community-based SMAs can be a feasible and acceptable intervention for patients with neighborhood disadvantage, especially in partnership with trusted organizations.
Treatment of Catatonia with Asenapine in a Patient with Schizotypal Personality Disorder, Psychotic Depression and Septic Shock from SARSCoV- 2 - A Case Report
Authors: Fiaschè Federica , Adriani Barbara , Mancinelli Iginia , Taranto Aldo 
Published: February 2021

Introduction:
Catatonia is a psychomotor syndrome that presents with severe symptoms
which can lead to dangerous and lethal conditions if not diagnosed and treated properly. SARS--
CoV-2 is a positive-sense single-stranded RNA virus that can occur in severe cases with acute
pneumonia, ARDS, sepsis and septic shock. In these cases, ICU admission is necessary.

Case Summary:
A 59-year-old Caucasian man with septic shock and bilateral interstitial pneumonia
from SARS-CoV-2 and schizotypal personality disorder presented with catatonic behaviour
manifested by soporous state, response to intense painful stimuli with the opening of the eyes, execution
of simple verbal commands, maintenance of the same position, catalepsy, immobility, rigidity
and mutism. At the same time, there were symptoms of septic shock and catatonic symptoms,
causing greater difficulty in the correct formulation of the diagnosis. During the course of his hospitalization,
he was treated with asenapine 20 mg/day. The catatonia responded rapidly and significantly
to the asenapine.

Discussion:
To date, the pathophysiology of catatonia is unclear, and few guidelines are available
for the treatment of catatonia. In the literature, studies have reported the efficacy of benzodiazepines
such as lorazepam and diazepam, GABAA agonists such as zolpidem, NMDA receptor antagonists
such as memantine, antidepressant SSRIs such as fluoxetine and paroxetine, and antipsychotics
such as olanzapine, clozapine and aripiprazole. We demonstrate that the antipsychotic asenapine
is also effective in treating catatonic symptoms in psychiatric disorders.

Conclusion:
Asenapine produced a rapid and significant reduction in catatonic symptoms in our patient
with schizotypal personality disorder.