bluuebunny/crossref_metadata_2025_split huggingface dataset:
Armenian, Georgian, and Church Slavonic Versions
Authors: Torijano Pablo A. 
Published: February 2021

AbstractThe Armenian, Georgian, and Slavonic versions constitute a useful secondary witness to the text of the LXX and its history. These versions follow quite closely the recensional history of their Greek Vorlage. Their study and use in LXX textual criticism present problems due to the sheer number of manuscript witnesses and the lack of editions that follow modern editorial standards. The three versions were the first works of their national literatures and caused the invention of their respective scripts. Both the Armenian and the Georgian attest OG readings partially preserved in the Greek tradition. The Church Slavonic version should be used with more care; it kept being edited to adapt the original translation to linguistic changes, producing a very mixed text whose variants do not reflect necessarily a Greek Vorlage but different linguistic and geographical stages of the translation.
Textual Criticism
Authors: Lemmelijn Bénédicte 
Published: February 2021

AbstractOnce upon a time, the task of defining ‘textual criticism’, its aims and methods, was relatively straightforward. The ‘modern’ idea of unilateral rational criticism was confident of reconstructing unambiguously the development of the biblical text back to its single point of origin. However, increasing factual evidence and developing insight have brought us today to a much more complicated situation. Within this context, the role that the Septuagint plays within the process of textual criticism of the Hebrew Bible has also undeniably changed. This chapter first describes how textual ‘facts’ have changed our understanding of the development of the biblical textual material and how they have changed our view and perception of the discipline of textual criticism itself. Thereafter, it will focus on the role that the Septuagint has played within this changing panorama and illustrate this altered significance of the Septuagint on the basis of a concrete textual example.
Josephus and the Septuagint
Authors: Rajak Tessa 
Published: February 2021

Abstract
The primary concern of the present chapter is to establish what the Greek Bible meant for Josephus. We ask how his own Greek version of the Bible was facilitated by the Septuagint, or rather by Greek translations current in his day, and more precisely how far we can establish whether such texts underlie his own presentation. At the same time, any such investigation will also tell us important things about the fate and fortunes of LXX, above all within first-century Judaism. There is much more in this exploration than just the occasional light that Josephus’s renderings have shed on the history of the versions, though it is for textual evidence that Josephus has mainly been invoked in LXX scholarship.
The Letter of Aristeas
Authors: De Crom Dries 
Published: February 2021

Abstract
Even though the Letter of Aristeas was unmasked as a pseudepigraphon over 400 years ago, the question of its value as a historical source continues to dominate the field of Septuagint Studies. First, this chapter discusses how the genre of the Letter of Aristeas is actually a mix of historiography, rhetorical display, Hellenistic philosophy, and biblical wisdom literature. Next, it discusses several recent approaches to the problem of historicity: the search for a kernel of historical truth in the Letter, the application of insights from the study of ancient historiography, and the Letter as a source for the reception history of the Septuagint. Finally, it addresses the identification of the Aristeas story as a social myth of Alexandrian Jewish society.
Syntaxin of plants31 (SYP31) and SYP32 is essential for Golgi morphology maintenance and pollen development
Authors: Rui Qingchen , Tan Xiaoyun , Liu Feng , Li Yanbin , Liu Xin , Li Bingxuan , Wang Junxia , Yang Huiting , Qiao Lixin , Li Tingting , Fang Shuo , Gao Rongrong , Wang Wang , Bednarek Sebastian Y , Bao Yiqun 
Published: February 2021

AbstractPollen development is a key process for the sexual reproduction of angiosperms. The Golgi plays a critical role in pollen development via the synthesis and transport of cell wall materials. However, little is known about the molecular mechanisms underlying the maintenance of Golgi integrity in plants. In Arabidopsis thaliana, syntaxin of plants (SYP) 3 family proteins SYP31 and SYP32 are the only two Golgi-localized Qa-soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs) with unknown endogenous functions. Here, we demonstrate the roles of SYP31 and SYP32 in modulating Golgi morphology and pollen development. Two independent lines of syp31/+ syp32/+ double mutants were male gametophytic lethal; the zero transmission rate of syp31 syp32 mutations was restored to largely normal levels by pSYP32:SYP32 but not pSYP32:SYP31 transgenes, indicating their functional differences in pollen development. The initial arrest of syp31 syp32 pollen occurred during the transition from the microspore to the bicellular stage, where cell plate formation in pollen mitosis I (PMI) and deposition of intine were abnormal. In syp31 syp32 pollen, the number and length of Golgi cisterna were significantly reduced, accompanied by many surrounding vesicles, which could be largely attributed to defects in anterograde and retrograde trafficking routes. SYP31 and SYP32 directly interacted with COG3, a subunit of the conserved oligomeric Golgi (COG) complex and were responsible for its Golgi localization, providing an underlying mechanism for SYP31/32 function in intra-Golgi trafficking. We propose that SYP31 and SYP32 play partially redundant roles in pollen development by modulating protein trafficking and Golgi structure.
OsGRETCHENHAGEN3-2modulates rice seed storability via accumulation of abscisic acid and protective substances
Authors: Yuan Zhiyang , Fan Kai , Wang Yuntong , Tian Li , Zhang Chaopu , Sun Wenqiang , He Hanzi , Yu Sibin 
Published: February 2021

AbstractSeed storability largely determines the vigor of seeds during storage and is significant in agriculture and ecology. However, the underlying genetic basis remains unclear. In the present study, we report the cloning and characterization of the rice (Oryza sativa) indole-3-acetic acid (IAA)-amido synthetase gene GRETCHEN HAGEN3-2 (OsGH3-2) associated with seed storability. OsGH3-2 was identified by performing a genome-wide association study in rice germplasms with linkage mapping in chromosome substitution segment lines, contributing to the wide variation of seed viability in the populations after long periods of storage and artificial ageing. OsGH3-2 was dominantly expressed in the developing seeds and catalyzed IAA conjugation to amino acids, forming inactive auxin. Transgenic overexpression, knockout, and knockdown experiments demonstrated that OsGH3-2 affected seed storability by regulating the accumulation level of abscisic acid (ABA). Overexpression of OsGH3-2 significantly decreased seed storability, while knockout or knockdown of the gene enhanced seed storability compared with the wild-type. OsGH3-2 acted as a negative regulator of seed storability by modulating many genes related to the ABA pathway and probably subsequently late embryogenesis-abundant proteins at the transcription level. These findings shed light on the molecular mechanisms underlying seed storability and will facilitate the improvement of seed vigor by genomic breeding and gene-editing approaches in rice.
Stress Tests, Entrepreneurship, and Innovation
Authors: Doerr Sebastian 
Published: February 2021

Abstract
This article shows that postcrisis stress tests have negative effects on entrepreneurship and innovation at young firms. Exploiting unique data on business-related home equity loans in Home Mortgage Disclosure Act, I show that stress-tested banks strongly cut small business loans secured by home equity, an important source of financing for entrepreneurs. Lower credit supply leads to a relative decline in entrepreneurship in counties with higher exposure to stress-tested banks. The decline is stronger in sectors with a higher share of young firms using home equity financing, that is, in which the reduction in credit hits hardest. More-exposed counties also see a decline in young firms’ patent applications as well as labor productivity, reflecting young firms’ disproportionate contribution to growth.
Current Trends in Genetics and Neonatal Care
Authors: Uveges Melissa K. , Holm Ingrid A. 
Published: February 2021

Background:
Genetic and genomic health applications are rapidly changing. A clear and updated description of these applications for the neonatal population is needed to guide current nursing practice.

Purpose:
To provide scientific evidence and guidance on the current genetic and genomic applications pertinent to neonatal care.

Methods:
A search of CINAHL and PubMed was conducted using the search terms “newborn/neonatal” and “genetics,” “genomics,” “newborn screening,” “pharmacogenomics,” “ethical,” and “legal.” Google searches were also conducted to synthesize professional guidelines, position statements, and current genetic practices.

Findings/Results:
Components of the newborn genetic assessment, including details on the newborn physical examination, family history, and laboratory tests pertinent to the newborn, are reported. The history and process of newborn screening are described, in addition to the impact of advancements, such as whole exome and genome sequencing, on newborn screening. Pharmacogenomics, a genomic application that is currently utilized primarily in the research context for neonates, is described and future implications stated. Finally, the specific ethical and legal implications for these genetic and genomic applications are detailed, along with genetic/genomic resources for nurses.

Implications for Practice:
Providing nurses with the most up-to-date evidence on genetic and genomic applications ensures their involvement and contributions to quality neonatal care.

Implications for Research:
Ongoing genetic/genomic research is needed to understand the implications of genetic/genomic applications on the neonatal population and how these new applications will change neonatal care.
Polypharmacy, Dosing Trends, and Drug-Drug Interaction Patterns After High-Level Limb Amputation Surgery
Authors: Bastas Gerasimos , Dallas Jonathan , Miller Patricia Blair , Kloosterman Nicole , Yannopoulos Ion 
Published: February 2021

ObjectiveThe aim of this study was to examine perioperative medication patterns surrounding major amputation surgeries.DesignA retrospective chart review of 216 cases of major amputations (transfemoral, hip disarticulation, hemipelvectomy, forequarter) at an academic hospital was conducted, examining medications, dosing changes, and drug-drug interaction warnings preoperatively and postoperatively.ResultsMedications increased in 76.9% (166/216), remained the same in 10.6% (23/216), and decreased in 12.5% (27/216) of cases. Average number of medications was 7 preoperatively and 10 postoperatively. In 189 cases with preoperative medications present, postoperative dosing remained the same for 74.3%, increased for 9.2%, decreased for 7.6%, and was unknown for 8.9% of medications. Increases in each of type C (“monitor therapy”), D (“consider therapy modification), and X (“avoid combination”) drug-drug interaction warnings were seen respectively in 59.7%, 62.0%, and 5.1% of cases.ConclusionPolypharmacy is involved preoperatively and increased postoperatively in most cases of major limb amputation, with agent dosing remaining the same or increased in most cases. Drug-drug interaction warnings also increase. These occur at a time of abrupt changes to the body’s size, compartments, and physiologic responses. More research and clinical attention are warranted given anticipated changes in pharmacokinetics and pharmacodynamics.
Second Victim Experience and Support Tool: An Assessment of Psychometric Properties of Italian Version
Authors: Pieretti Alessia , Bastiani Luca , Bellandi Tommaso , Molinaro Sabrina , Zoppi Paolo , Rasero Laura 
Published: February 2021

Introduction
Second victim syndrome is a hidden pitfall inside health care organizations. The impact of a patient safety incident on health and safety of health care workers (HCWs) is still a matter with limited evidence in terms of prevalence, etiology, and effects. The aims of this study were to validate the Italian version of the Second Victim Experience and Support Tool (I-SVEST) and determine its psychometric properties in a group of HCWs exposed to patient safety incidents.

Materials and Methods
An observational cross-sectional study was conducted using an online survey. Construct validity for the total score and for each of the 7 subscales was assessed using principal component analysis and internal consistency using Cronbach α coefficient.

Results
The prevalence of second victims in our sample was 35.4% (85/240). The component SVEST was positively associated with turnover intentions but not directly related to absenteeism and sociodemographic characteristics. Absenteeism and sociodemographic characteristics components were positively associated with turnover intentions. Factor analysis confirmed that the questionnaire has 7 dimensions: psychological distress, physical distress, colleague support, supervisor support, institutional support, non–work-related support, and professional self-efficacy. Cronbach α for the Italian version was strong at α = 0.855. Cronbach α ranged from 0.613 for colleague support to 0.882 for supervisor support.

Conclusions
The Italian version of the SVEST has excellent psychometric properties and can be used to detect prevalence in different contexts, to support studies and preventive interventions for Italian HCWs. The SVEST provides a robust model to describe the concept of second victim and to conduct comparisons with cross-sectional and longitudinal studies.
Racial/Ethnic Disparities in Young Adulthood and Midlife Cardiovascular Risk Factors and Late-life Cognitive Domains
Authors: Peterson Rachel L. , George Kristen M. , Gilsanz Paola , Ackley Sarah , Mayeda Elizabeth R. , Glymour M.M. , Mungas Dan M. , DeCarli Charles , Whitmer Rachel A. 
Published: February 2021

Background:
Midlife cardiovascular risk factors (CVRF) increase dementia risk. Less is known about whether CVRF identified before midlife impact late-life cognition in diverse populations.

Methods:
Linear regression models examined hypertension, hyperlipidemia, and overweight/obesity at ages 30 to 59 with late-life executive function, semantic memory, verbal episodic memory, and global cognition in a cohort of Asians, blacks, Latinos, and whites (n=1127; mean age=75.8, range=65 to 98). Models adjusted for age at CVRF, age at cognitive assessment, sex, race/ethnicity, participant education, and parental education.

Results:
Overall, 34% had 1 CVRF at ages 30 to 59; 19% had 2+. Blacks (26%) and Latinos (23%) were more likely to have 2+ CVRF than Asians (14%) or whites (13%). Having 2+ CVRF was associated with lower global cognition [β=−0.33; 95% confidence interval (CI)=−0.45, −0.21], executive function (β=−0.26; 95% CI=−0.39, −0.13), verbal episodic memory (β=−0.34; 95% CI=−0.48, −0.20), and semantic memory (β=−0.20; 95% CI=−0.33, −0.07). Interaction by age (P=0.06) indicated overweight/obesity was negatively associated with executive function at ages 30 to 39 but not at ages 40 to 59. Race/ethnic-specific effects showed disparities in CVRF prevalence impact population disparities in late-life cognition.

Conclusion:
Being overweight/obese in early adulthood and having 2+ CVRF in early adulthood/midlife are modifiable targets to redress racial/ethnic disparities in cognitive impairment and dementia.
Bridging the gap between rectifying developables and tangent developables: a family of developable surfaces associated with a space curve
Authors: Seguin Brian , Chen Yi-chao , Fried Eliot 
Published: February 2021

There are two familiar constructions of a developable surface from a space curve. The tangent developable is a ruled surface for which the rulings are tangent to the curve at each point and relative to this surface the absolute value of the geodesic curvature
κ

g

of the curve equals the curvature
κ
. The alternative construction is the rectifying developable. The geodesic curvature of the curve relative to any such surface vanishes. We show that there is a family of developable surfaces that can be generated from a curve, one surface for each function
k
that is defined on the curve and satisfies |
k
| ≤
κ
, and that the geodesic curvature of the curve relative to each such constructed surface satisfies
κ

g

=
k
.
Spinal fluid antibodies against multiple sclerosis candidate bacteria in demyelinating disease
Authors: Eckman Emily , Laman Jon D. , Fischer Kael F. , Lopansri Bert , Martins Tom B. , Hill Harry R. , Kriesel John D. 
Published: February 2021

ABSTRACTA panel of 10 IgG enzyme-linked immunosorbent assays (ELISAs) were developed for the detection of anti-microbial immune responses in the cerebrospinal fluid (CSF) of patients with demyelinating diseases (DD). Selection of the anti-microbial ELISA assays was guided by previous RNA sequencing studies that established a multiple sclerosis (MS) microbial candidate list. Microbial antigens included on the ELISA panel were derived from Akkermansia muciniphila, Atopobium vaginae, Bacteroides fragilis, Lactobacillus paracasei, Odoribacter splanchnicus, Pseudomonas aeruginosa, Cutibacterium (Propionibacterium) acnes, Fusobacterium necrophorum, Porphyromonas gingivalis, and Streptococcus mutans. Spinal fluid responses from patients with demyelinating diseases (DD, N=14) were compared to those with other neurological diseases (OND, N=8), and non-MS (Control, N=13) control patients. Commercial positive and negative control CSF specimens were run with each assay. ELISA Index values were derived for each specimen against each of the 10 bacterial antigen preparations. Intrathecal production of anti-microbial antibodies was assessed by comparing CSF and comparably diluted serum. CSF reactivity was significantly higher in the DD group compared to the controls against Akkermansia, Atopobium, Bacteroides, Lactobacillus, Odoribacter, and Fusobacterium. Four of the 11 tested DD group subjects had elevated antibody indexes against at least one of the 10 bacterial antigens, suggesting intrathecal production of anti-bacterial antibodies. This CSF serological study supports the hypothesis that several of the previously identified MS candidate microbes may contribute to demyelination in some patients.
State-Anxiety Modulates the Effect of Emotion Cues on Visual Temporal Sensitivity in Autism Spectrum Disorder
Authors: Chakrabarty Mrinmoy , Atsumi Takeshi , Yaguchi Ayako , Fukatsu Reiko , Ide Masakazu 
Published: February 2021

AbstractAtypical processing of stimulus inputs across a range of sensory modalities in autism spectrum disorders (ASD) are widely reported. Sensory processing is known to be influenced by bodily internal states such as physiological arousal and anxiety. Since a sizeable proportion of ASD individuals reportedly have co-morbid anxiety disorders that are linked with dysregulated arousal, we investigated if face-emotion arousal cues, influenced visual sensory sensitivity (indexed by temporal resolution) in an ASD group (n=20) compared to a matched group of typically-developed individuals (TD, n=21). We asked further if emotion-cued changes in visual sensitivity associated with individual differences in state- and trait-anxiety. Participants reported the laterality of the second of two consecutive Gaussian-blob flashes in a visual temporal order judgment task (v-TOJ), demanding higher-level visual processing. The key manipulation was presenting a task-irrelevant face emotion cue briefly at unexpected time points preceding the task-relevant flashes. Disgust vs Neutral emotion signals enhanced the visual temporal resolution in ASD individuals. Furthermore, individual state-anxiety scores correlated with the emotion-cued change of temporal resolution (Disgust vs Neutral) in the ASD group. Both these effects were absent in the TD group. The results show that individual state-anxiety levels significantly modulate the effect of emotions on visual temporal sensitivity in ASD individuals, which was absent in our TD sample. The findings support a nuanced approach to understand the disparate sensory features in ASD individuals, by factoring in the interplay of the individual reactivity to environmental affective information and the severity of anxiety.
Protocol for rapid implementation of a SARS-CoV-2 sero-survey during the 2020 COVID-19 pandemic – who, where, how?
Authors: Smith Daniel , Mac Valerie , Yang Irene , Butts Brittany , Hecker Morgan , Howell J. Christina , Ozturk Tugba , Pirmohammed Shama , Huang Hanfeng , Kippels Andrea , Brewster Glenna , Verble Danielle D , Jacobs Winnie , Hu William T. , Wharton Whitney 
Published: February 2021

AbstractIntroductionThe 2019 novel coronavirus disease (COVID-19) pandemic has had devastating consequences in the US, yet clinical research on its natural history and transmission outside hospitalized settings has faced tangible and intangible challenges due to uncertainty in testing, case ascertainment, and appropriate safety measures. To better understand temporal evolution of COVID-19 related serological and other immune responses during a pandemic, we designed and implemented a baseline cross-sectional study of asymptomatic community volunteers and first responders in metro-Atlanta before the predicted infection peak in 2020.MethodsWe recruited healthy community volunteers and first responders for health history, serology, and biobanking. Through an iterative process, we identified one location on our campus and one community location which were accessible, vacant, distant from COVID-19 testing sites, open for social distancing, private for informed consent, and operational for sanitation and ventilation. Research and cleaning supplies were obtained from other researchers and private online vendors due to shortages, and faculty directly participated in consenting and phlebotomy.ResultsA total of 369 participants completed the study visits over six full and three half days. Over half of Phase 1 (174/299, 58.2%) and Phase 2 (45/70, 64.3%) self-reported as healthcare workers, and there was a high percentage of participants reporting exposure to known COVID-19 cases (48.2% and 61.4%).ConclusionsRigorous prospective clinical research with informed consents and is possible during a pandemic. Effective recruitment for moderately large sample size is facilitated by direct faculty involvement, connections with the community, and non-financial support from colleagues and the institution.