bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medium induced QCD cascades: broadening and rescattering during branching
Authors: Blanco E. , Kutak K. , Płaczek W. , Rohrmoser M. , Straka R. 
Published: April 2021

Abstract
We study evolution equations describing jet propagation through quark-gluon plasma (QGP). In particular we investigate the contribution of momentum transfer during branching and find that such a contribution is sizeable. Furthermore, we study various approximations, such as the Gaussian approximation and the diffusive approximation to the jet-broadening term. We notice that in order to reproduce the BDIM equation (without the momentum transfer in the branching) the diffusive approximation requires a very large value of the jet-quenching parameter $$ \hat{q} $$

q
̂

.
Light quark Yukawas in triboson final states
Authors: Falkowski Adam , Ganguly Sanmay , Gras Phillippe , No Jose Miguel , Tobioka Kohsaku , Vignaroli Natascia , You Tevong 
Published: April 2021

Abstract
Triple heavy vector boson production, pp → VVV (V = W, Z), has recently been observed for the first time. We propose that precision measurements of this process provide an excellent probe of the first generation light quark Yukawa couplings. Modified quark interactions with the off-shell Higgs in this process lead to a rapid growth of the partonic cross sections with energy, which manifests in an enhanced pT distribution of the final state leptons and quarks. We quantify this effect and estimate the present and future 2σ sensitivity to the up, down, and strange Yukawas. In particular, we find that HL-LHC can reach $$ \mathcal{O}(400) $$
O

400

sensitivity to the down Yukawa relative to the Standard Model value, improving the current sensitivity in this process by a factor of 10, and which can be further improved to $$ \mathcal{O}(30) $$
O

30

at FCC-hh. This is competitive with and complementary to constraints from global fits and other on-shell probes of the first generation Yukawas. The triboson sensitivity at HL-LHC corresponds to probing dimension-6 SMEFT operators suppressed by an $$ \mathcal{O}(1) $$
O

1

TeV scale, similarly to other LHC Higgs probes.
Revisiting the role of mitochondria in spinal muscular atrophy
Authors: James Rachel , Chaytow Helena , Ledahawsky Leire M. , Gillingwater Thomas H. 
Published: April 2021

AbstractSpinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease of variable clinical severity that is caused by mutations in the survival motor neuron 1 (SMN1) gene. Despite its name, SMN is a ubiquitous protein that functions within and outside the nervous system and has multiple cellular roles in transcription, translation, and proteostatic mechanisms. Encouragingly, several SMN-directed therapies have recently reached the clinic, albeit this has highlighted the increasing need to develop combinatorial therapies for SMA to achieve full clinical efficacy. As a subcellular site of dysfunction in SMA, mitochondria represents a relevant target for a combinatorial therapy. Accordingly, we will discuss our current understanding of mitochondrial dysfunction in SMA, highlighting mitochondrial-based pathways that offer further mechanistic insights into the involvement of mitochondria in SMA. This may ultimately facilitate translational development of targeted mitochondrial therapies for SMA. Due to clinical and mechanistic overlaps, such strategies may also benefit other motor neuron diseases and related neurodegenerative disorders.
CMTM6 expression in M2 macrophages is a potential predictor of PD-1/PD-L1 inhibitor response in colorectal cancer
Authors: Wu Xuehui , Lan Xiaoliang , Hu Wanming , Zhang Wanning , Lai Xiangmeng , Xu Shaowan , Li Jiaoying , Qiu Weihao , Wang Wei , Xiao Jianbiao , Wang Feifei , Ding Yanqing , Liang Li 
Published: April 2021

Abstract
Background
CMTM6 is a novel key regulator of PD-L1. High expression of both CMTM6 and PD-L1 may predict the benefit of PD-1 axis blockade in lung cancer. We aimed to investigate the expression pattern of CMTM6 between mismatch repair-defective (dMMR) and mismatch repair-proficient (pMMR) colorectal cancer (CRC) tissues and assess its correlation with the response to PD-1/PD-L1 pathway blockade.

Methods
Immunohistochemistry (IHC) was used to analyze CMTM6 and PD-L1 expression and immune cell density in dMMR/pMMR CRC. Quantitative multiplex immunofluorescence (IF) was performed to detect CMTM6, PD-L1, CD4, CD8, CD68 and CD163 expression in CRC patients treated with PD-1/PD-L1 inhibitors.

Result
IHC analysis showed that CMTM6 and PD-L1 were both expressed in tumor cells (TCs) and invasion front immune cells (ICs). CMTM6 and PD-L1 expression and CD4+, CD8+, CD68+ or CD163+ cell density were significantly higher in dMMR CRC patients than in pMMR CRC patients. CMTM6 expression was positively correlated with PD-L1 expression and CD163+ M2 macrophage density in dMMR CRC. IF analysis showed that the coexpression rate of CMTM6/PD-L1 and the expression rate of CMTM6 in CD8+ T cells and CD163+ M2 macrophages were significantly increased in the group that exhibited clinical benefit. CMTM6 expression in M2 macrophages was identified as the best biomarker for predicting the responsiveness to PD-1/PD-L1 inhibitors.

Conclusions
CMTM6 expression in M2 macrophages may predict the PD-1/PD-L1 inhibitor response rate in CRC patients more accurately than dMMR/microsatellite instability-high (MSI-H) status. It can also identify pMMR CRC patients who could benefit from PD-1/PD-L1 inhibitors.
Corrigendum to “Best match graphs”
Authors: Schaller David , Geiß Manuela , Chávez Edgar , González Laffitte Marcos , López Sánchez Alitzel , Stadler Bärbel M. R. , Valdivia Dulce I. , Hellmuth Marc , Hernández Rosales Maribel , Stadler Peter F. 
Published: April 2021

AbstractTwo errors in the article Best Match Graphs (Geiß et al. in JMB 78: 2015–2057, 2019) are corrected. One concerns the tacit assumption that digraphs are sink-free, which has to be added as an additional precondition in Lemma 9, Lemma 11, Theorem 4. Correspondingly, Algorithm 2 requires that its input is sink-free. The second correction concerns an additional necessary condition in Theorem 9 required to characterize best match graphs. The amended results simplify the construction of least resolved trees for n-cBMGs, i.e., Algorithm 1. All other results remain unchanged and are correct as stated.
The Craterostigma plantagineum protein kinase CpWAK1 interacts with pectin and integrates different environmental signals in the cell wall
Authors: Chen Peilei , Giarola Valentino , Bartels Dorothea 
Published: April 2021

Abstract
Main conclusion
The cell wall protein CpWAK1 interacts with pectin, participates in decoding cell wall signals, and induces different downstream responses.

Abstract
Cell wall-associated protein kinases (WAKs) are transmembrane receptor kinases. In the desiccation-tolerant resurrection plant Craterostigma plantagineum, CpWAK1 has been shown to be involved in stress responses and cell expansion by forming a complex with the C. plantagineum glycine-rich protein1 (CpGRP1). This prompted us to extend the studies of WAK genes in C. plantagineum. The phylogenetic analyses of WAKs from C. plantagineum and from other species suggest that these genes have been duplicated after species divergence. Expression profiles indicate that CpWAKs are involved in various biological processes, including dehydration-induced responses and SA- and JA-related reactions to pathogens and wounding. CpWAK1 shows a high affinity for “egg-box” pectin structures. ELISA assays revealed that the binding of CpWAKs to pectins is modulated by CpGRP1 and it depends on the apoplastic pH. The formation of CpWAK multimers is the prerequisite for the CpWAK–pectin binding. Different pectin extracts lead to opposite trends of CpWAK–pectin binding in the presence of Ca2+ at pH 8. These observations demonstrate that CpWAKs can potentially discriminate and integrate cell wall signals generated by diverse stimuli, in concert with other elements, such as CpGRP1, pHapo, Ca2+[apo], and via the formation of CpWAK multimers.
Chronically ill children’s participation and health outcomes in shared decision-making: a scoping review
Authors: Wijngaarde R. O. , Hein I. , Daams J. , Van Goudoever J. B. , Ubbink D. T. 
Published: April 2021

AbstractBased on the United Nations Conventions on the Rights of the Child (CRC), it is a child’s right to participate in all matters concerning its wellbeing. Little is known about chronically and/or critically ill children’s participation in pediatric shared decision-making (SDM). We explored medical literature to see if and how these children participate in pediatric SDM. We searched relevant medical databases published between January 2008 and January 2020 for studies targeting children aged 4–18 years old, suffering from a chronic and/or critical disease. We found 9 relevant studies. SDM interventions mostly used were decision aids (n=8), questionnaires for caretakers/parents and children (n=4), and a SDM toolkit (n=2). Perceived involvement in SDM and knowledge increased amongst children, adolescents, and caretakers following these interventions. Decisional conflict measured using the 0–100 point DCS scale (higher scores indicate more decisional conflict) was reduced by 15.9 points in one study (p<0.01) and 17.8 points in another (95%CI: 13.3–22.9). Lower scores were associated with higher satisfaction with the decision aid by children, caretakers, and clinicians.Conclusion: Stakeholders should advocate initiatives to facilitate a child’s participation preferences regarding pediatric SDM since decision support tools help chronically ill children to be more involved in SDM as they increase the children’s knowledge and satisfaction and reduce decisional conflicts.

What is Known:• Decision aids can help improve participation, knowledge, satisfaction, and health outcomes.• Quality and consistency of the information exchange impact quality and outcome of SDM.

What is New:• Depending on a child’s age, evolving capacities, and communication and participation preferences, more evidence is needed on which tools are suitable for chronically ill children to ensure their preferred participation in pediatric SDM.• Pediatricians adopt healthcare SDM tools and techniques that do not always take into account that a child’s right to participate in pediatric SDM including the tendency to use interventions that are not specifically designed for pediatrics.
Evaluation of the impact of the COVID-19 lockdown on the quality of life of patients monitored for cancer who practice an adapted physical activity: rugby for health
Authors: Motton Stéphanie , Vergriete Kelig , VanPhi Luc Nguyen , Lambaudie Eric , Berthoumieu Audrey , Pous Jean , Delannes Martine , Piscione Julien , Cornou Caroline , Bataille Benoit , Saxod Diane , Pillard Fabien 
Published: April 2021

Abstract
Purpose
The benefits of regular physical exercise on the tolerability of cancer treatments, quality of life and survival rates post-diagnosis have been demonstrated but all supervised physical activities have been interrupted due to the global health crisis and the need for lockdown to halt the spread of SARS-CoV-2. To reintroduce activities post-lockdown, we wanted to assess the impact of the COVID-19 lockdown on the quality of life and the psychological status of patients who practice an adapted physical activity such as rugby for health.

Methods
The evaluation was conducted in two phases: an initial self-questionnaire comprised of 42 questions sent to all participants to assess the impact of lockdown and a second assessment phase in the presence of the participants. We assessed anthropometric data, functional fitness parameters, quality of life and the psychosocial status of the subjects. The data were compared to pre-lockdown data as part of a standardised follow-up procedure for patients enrolled in the programme.

Results
105/120 (87.5%) individuals responded to the rapid post-lockdown survey analysis. In 20% of the cases, the patients reported anxiety, pain, a decline in fitness and a significant impact on the tolerability of cancer treatments. Twenty-seven patients agreed to participate in the individual analysis. Following lockdown, there was a significant decrease in the intensity of physical activity (p = 8.223e–05). No post-lockdown changes were noted in the assessments that focus on the quality of life and the level of psychological distress. Conversely, there was a significant correlation between the total of high energy expended during lockdown and the quality of life (p = 0.03; rho = 0.2248) and the level of psychological distress post-lockdown (p = 0.05; rho = − 0.3772).

Conclusion
Lockdown and reduced physical activity, particularly leisure activities, did not impact the overall health of the patients. However, there was a significant correlation with the level of physical activity since the higher the level of physical activity, the better the quality of life and the lower the level of psychological distress.
Planarity and non-separating cycles in uniform high genus quadrangulations
Authors: Louf Baptiste 
Published: April 2021

AbstractWe study large uniform random bipartite quadrangulations whose genus grows linearly with the number of faces. Their local convergence was recently established by Budzinski and the author [9, 10]. Here we study several properties of these objects which are not captured by the local topology. Namely we show that balls around the root are planar with high probability up to logarithmic radius, and we prove that there exist non-contractible cycles of constant length with positive probability.
Impact of Second Phase Content on Rock Salt Rheological Behavior Under Cyclic Mechanical Conditions
Authors: Martin-Clave Carla , Ougier-Simonin Audrey , Vandeginste Veerle 
Published: April 2021

AbstractSafe Underground Gas Storage (UGS) can be achieved in artificial, salt caverns to meet fluctuations in energy demand by providing adequate knowledge on rock salt when subjected to similar cyclic conditions. In this study, we performed cyclic mechanical tests on five rock salt samples with different types and amounts of second-phase mineral content. A confining pressure of 25 MPa was applied, whilst the axial stress was cycled between 4.5 and 7.5 MPa, at 0.5 kN/s loading rate, during 48 h (7200 cycles). The results demonstrate that high second-phase content such as anhydrite layering operates as a strength weakening agent by accommodating larger brittle deformation in comparison to samples with a lower content in secondary minerals. This rheological behavior is further exacerbated by the cycling mechanical conditions and recorded by a marked step on Young’s modulus and Poisson’s ratio value evolution. The microstructure analysis reveals how halite grains accommodate most of the deformation induced by the cyclic mechanical loading conditions through brittle deformation with microfracturing network development. Other structures from different deformation mechanisms are also discussed. Two types of new porosity are observed: (i) pores around isolated crystals of second-phase minerals as a result of grain rotation under cyclic mechanical deformation, and (ii) microcracks in areas with high concentration of secondary minerals (such as anhydrite, polyhalite, carnallite, or kieserite). This porosity change has strong implications for both the mechanical behavior of the material and its potential permeability.
Semantic Instance Segmentation of Kidney Cysts in MR Images: A Fully Automated 3D Approach Developed Through Active Learning
Authors: Gregory Adriana V. , Anaam Deema A. , Vercnocke Andrew J. , Edwards Marie E. , Torres Vicente E. , Harris Peter C. , Erickson Bradley J. , Kline Timothy L. 
Published: April 2021

AbstractTotal kidney volume (TKV) is the main imaging biomarker used to monitor disease progression and to classify patients affected by autosomal dominant polycystic kidney disease (ADPKD) for clinical trials. However, patients with similar TKVs may have drastically different cystic presentations and phenotypes. In an effort to quantify these cystic differences, we developed the first 3D semantic instance cyst segmentation algorithm for kidneys in MR images. We have reformulated both the object detection/localization task and the instance-based segmentation task into a semantic segmentation task. This allowed us to solve this unique imaging problem efficiently, even for patients with thousands of cysts. To do this, a convolutional neural network (CNN) was trained to learn cyst edges and cyst cores. Images were converted from instance cyst segmentations to semantic edge-core segmentations by applying a 3D erosion morphology operator to up-sampled versions of the images. The reduced cysts were labeled as core; the eroded areas were dilated in 2D and labeled as edge. The network was trained on 30 MR images and validated on 10 MR images using a fourfold cross-validation procedure. The final ensemble model was tested on 20 MR images not seen during the initial training/validation. The results from the test set were compared to segmentations from two readers. The presented model achieved an averaged R2 value of 0.94 for cyst count, 1.00 for total cyst volume, 0.94 for cystic index, and an averaged Dice coefficient of 0.85. These results demonstrate the feasibility of performing cyst segmentations automatically in ADPKD patients.
Human language evolution: a view from theoretical linguistics on how syntax and the lexicon first came into being
Authors: Fujita Haruka , Fujita Koji 
Published: April 2021

AbstractHuman language is a multi-componential function comprising several sub-functions each of which may have evolved in other species independently of language. Among them, two sub-functions, or modules, have been claimed to be truly unique to the humans, namely hierarchical syntax (known as “Merge” in linguistics) and the “lexicon.” This kind of species-specificity stands as a hindrance to our natural understanding of human language evolution. Here we challenge this issue and advance our hypotheses on how human syntax and lexicon may have evolved from pre-existing cognitive capacities in our ancestors and other species including but not limited to nonhuman primates. Specifically, we argue that Merge evolved from motor action planning, and that the human lexicon with the distinction between lexical and functional categories evolved from its predecessors found in animal cognition through a process we call “disintegration.” We build our arguments on recent developments in generative grammar but crucially depart from some of its core ideas by borrowing insights from other relevant disciplines. Most importantly, we maintain that every sub-function of human language keeps evolutionary continuity with other species’ cognitive capacities and reject a saltational emergence of language in favor of its gradual evolution. By doing so, we aim to offer a firm theoretical background on which a promising scenario of language evolution can be constructed.
Taking Exception: Philosophy of Technology as a Multidimensional Problem Space
Authors: Smith Dominic 
Published: April 2021

AbstractThis essay develops three key claims made in my 2018 book, Exceptional Technologies. Part one argues for ‘trivialising the transcendental’, to remove stigmas attached to the word ‘transcendental’ in philosophy in general and philosophy of technology in particular. Part two outlines the concept of ‘exceptional technologies’. These are artefacts and practices that show up as limit cases for our received pictures of what constitutes a ‘technology’ (what I refer to as our ‘pictures of method’) and that force us to reassess the conditions for the possibility of these pictures. I focus on the case of autonomous vehicles here, arguing that Google Street View provides a relatively better picture for approaching philosophical issues at stake than the famous ‘Trolley Problem’. Part three then concludes with a focus on Heidegger’s ‘Question Concerning Technology’ essay. Heidegger asserts that philosophical questioning ‘builds a way’ (1977: 3). I argue that philosophical approaches to technologies might better be considered in terms of a multidimensional problem space.
Stimmung/Nastrój as Content of Modern Science: On Musical Metaphors in Ludwik Fleck’s Theory of Thought Styles and Thought Collectives
Authors: Jarnicki Paweł 
Published: April 2021

AbstractThought style and thought collective are two well-known concepts from Ludwik Fleck’s theory of science, which he originally formulated in Polish and German. This paper contends that these two concepts cannot be fully understood without a third—Stimmung/nastrój, which is one of the musical metaphors that play an important role in Fleck’s thinking. Because it is most often translated into English as “mood”, Fleck’s musical metaphors are mostly lost in translation, appearing as mere rhetoric. Only if and when we understand Stimmung/nastrój in the musical meaning of attunement, we can fully understand thought collectives, for which Stimmung/nastrój is sine qua non, and thought style, which appears if and when a collective turns out to be an enduring and not a momentary one.
A note on the Fröhlich dynamics in the strong coupling limit
Authors: Mitrouskas David 
Published: April 2021

AbstractWe revise a previous result about the Fröhlich dynamics in the strong coupling limit obtained in Griesemer (Rev Math Phys 29(10):1750030, 2017). In the latter it was shown that the Fröhlich time evolution applied to the initial state$$\varphi _0 \otimes \xi _\alpha $$φ0⊗ξα, where$$\varphi _0$$φ0is the electron ground state of the Pekar energy functional and$$\xi _\alpha $$ξαthe associated coherent state of the phonons, can be approximated by a global phase for times small compared to$$\alpha ^2$$α2. In the present note we prove that a similar approximation holds for$$t=O(\alpha ^2)$$t=O(α2)if one includes a nontrivial effective dynamics for the phonons that is generated by an operator proportional to$$\alpha ^{-2}$$α-2and quadratic in creation and annihilation operators. Our result implies that the electron ground state remains close to its initial state for times of order$$\alpha ^2$$α2, while the phonon fluctuations around the coherent state$$\xi _\alpha $$ξαcan be described by a time-dependent Bogoliubov transformation.
Ganoderic Acid A Attenuates LPS-Induced Neuroinflammation in BV2 Microglia by Activating Farnesoid X Receptor
Authors: Jia Yue , Zhang Dandan , Yin Hua , Li Haoran , Du Jing , Bao Hongkun 
Published: April 2021

AbstractNeuroinflammation plays an important role in the onset and progression of neurodegenerative diseases. Microglia-mediated neuroinflammation have been proved to be the main reason for causing the neurodegenerative diseases. Ganoderic acid A (GAA), isolated from Ganoderma lucidum, showed anti-inflammatory effect in metabolism diseases. However, little research has been focused on the effect of GAA in neuroinflammation and the related mechanism. In the present study, lipopolysaccharide(LPS)-stimulated BV2 microglial cells were used to evaluate the anti-inflammatory capacity of GAA. Our data showed that GAA significantly suppressed LPS-induced BV2 microglial cells proliferation and activation in vitro. More strikingly, GAA promoted the conversion of BV2 microglial cells from M1 status induced by LPS to M2 status. Furthermore, GAA inhibited the pro-inflammatory cytokines release and promoted neurotrophic factor BDNF expression in LPS-induced BV2 microglial cells. Finally, we found that the expression of farnesoid-X-receptor (FXR) was prominently downregulated in LPS-stimulated BV2 microglial cells, antagonism of FXR with z-gugglesterone and FXR siRNA can reverse the effect of GAA in LPS-induced BV2 microglial cells. Taking together, our findings demonstrate that GAA can significantly inhibit LPS-induced neuroinflammation in BV2 microglial cells via activating FXR receptor.