bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Resource Guide to Support the Engagement of Mental Health Providers and Patients With Digital Health Tools: Multimethod Study
Authors: Strudwick Gillian , McLay David , Lo Brian , Shin Hwayeon Danielle , Currie Leanne , Thomson Nicole , Maillet Éric , Strong Vanessa , Miller Alanna , Shen Nelson , Campbell Janis 
Published: March 2021

Background
As mental illness continues to affect 1 in 5 individuals, and the need for support has increased during the COVID-19 pandemic, the promise of digital mental health tools remains largely unrealized due to a lack of uptake by patients and providers. Currently, most efforts on supporting the uptake of digital mental health tools remain fragmented across organizations and geography. There is a critical need to synthesize these efforts in order to provide a coordinated strategy of supporting the adoption of digital mental health tools.

Objective
The specific aim of this project is to develop a web-based resource document to support the engagement of mental health providers and patients in the use of digital mental health tools.

Methods
The web-based resource was developed using a multimethod approach. A grey literature review was conducted in 2019 to identify relevant toolkits that are available in the public domain. This was supplemented with an environmental scan where individuals with expertise in the development, acquisition, implementation, and evaluation of digital mental health tools were invited to contribute additional tools or documents not identified in the grey literature search. An engagement workshop was held with stakeholders to explore how the resource document should be developed and delivered. These findings were collectively used to develop the final iteration of the resource document.

Results
Based on a gray literature review and environmental scan with 27 experts, 25 resources were identified and included in the resource guide. These resources were developed for patients and providers by organizations from 5 countries. An engagement workshop was held with 14 stakeholders, and barriers related to cultural sensitivity, sustainability, and accessibility of the toolkit were identified. The final iteration of the resource document was developed by the research team using findings from the gray literature review, environmental scan, and engagement workshop. The contents of the 45-page resource guide are directed at mental health care providers, administrators, and patients (inclusive of families and caregivers).

Conclusions
The use of a multimethod approach led to the development of a resource guide that builds on existing evidence on digital mental health tools and was co-designed with stakeholders and end-users. The resource guide is now publicly available online for free and is being promoted through digital health and mental health websites. Future work should explore how this document can be integrated into clinical care delivery and pathways.
EVALUATION OF ANTI-OXYTOCIC ACTIVITY OF ASPARAGUS RACEMOSUS JINISH JOSE DEPARTMENT OF PHARMACOLOGY
Authors: P KALA 
Published: March 2021

Objective: The objective of the study was to evaluate the anti-oxytocic activity of ethanolic extract of Asparagus racemosus root.
Methods: Ethanolic extract of A. racemosus root was taken by Soxhlet extraction method. Wistar strain albino non-pregnant female rats of weight 200–300 g were pre-treated with estrogen and were sacrificed to take their uterus. The tissue was then mounted in an organ bath containing de Jalon’s solution. The response of the tissue to various doses of oxytocin alone and then on adding increasing doses of the alcoholic extracts of A. racemosus along with the dose of oxytocin which produces sub-maximal contraction were recorded on a smoked drum.
Results: Extract in doses up to 40 mg when given along with oxytocin 0.1 unit produced graded increase in contractions in rat uterus. From 80 mg onward graded blockade of contractions occurred with complete blockade at 200 mg. On complete removal of the extract by thorough washing, it was seen that oxytocin was again able to produce contractions of the rat uterus tissue.
Conclusion: The ethanolic extract of A. racemosus root had demonstrated good anti-oxytocic property.
VIWITHAN: A STANDARDIZED ASHWAGANDHA EXTRACT AMELIORATES OVALBUMININDUCED AIRWAY-INFLAMMATION AND OXIDATIVE STRESS IN MOUSE MODEL
Authors: HS VASAVI , HV SUDEEP , ILLURI RAMANAIAH , K SHYAMPRASAD 
Published: March 2021

Objective: Withania somnifera, commonly known as Ashwagandha, Indian ginseng, has been used in Ayurvedic and indigenous medicinal preparations for various disease conditions since long time. In the present study, we investigated the protective effects of Viwithan, a standardized proprietary extract from Ashwagandha roots, against airway-inflammation and oxidative stress modulation in an ovalbumin (OVA)-induced murine model of inflammation.
Methods: Allergic asthma was initiated in BALB/c mice by sensitizing with OVA on days 1 and 14, followed by intranasal challenge with OVA on days 27, 28, and 29. Mice were administered Viwithan (200 and 400 mg/kg) by oral gavage before challenge. Then, mice were evaluated for the presence of airway inflammation, production of allergen-specific cytokine response, lung pathology, and oxidative stress modulation.
Results: The results showed that treatment with Viwithan attenuated OVA-induced lung inflammation in mice. Viwithan significantly attenuated inflammatory cell infiltration into the bronchoalveolar lavage fluid and markedly reduced the levels of pro-inflammatory cytokines, interleukin-10, and transforming growth factor-β1 in lung tissues. Viwithan treatment considerably reduced the lung weight in OVA-sensitized mice. Viwithan markedly attenuated the OVA-induced generation of reactive oxygen species in lung tissues.
Conclusion: Together, these results suggested that Viwithan alleviates OVA-induced airway-inflammation and oxidative stress, highlighting the potential of standardized Ashwagandha extract as a useful therapeutic agent for pulmonary fibrosis management.
EVALUATION OF RATIONAL USE OF ANTIBIOTIC DRUGS IN SURGERY DEPARTMENT AT A TERTIARY CARE HOSPITAL
Authors: NYAYAKAR SREEJA , MS MANDARA , M HEMALATHA , LALLAWMAWMI  , MOHAMMED SALAHUDDIN  , HASANI FATEMEH 
Published: March 2021

Objective: Antibiotics are the only drug where use in one patient can impact the effectiveness in another, so antibiotic misuse adversely impacts the patients and society. Improving antibiotic use improves patient outcomes and saves money. Antibiotic resistance has been identified as a major threat by the WHO due to the lack of development of new antibiotics and the increasing infections caused by multidrug resistance pathogens became untreatable.
Methods: A prospective observational study was conducted for a period of 6 months. Data were collected from prescriptions and inpatient record files at the surgery department of the tertiary care hospital. Patients above age of 18 years of either gender whose prescription containing the antibiotics and patients who are willing to participate in the study were included in the study. Microsoft Excel was used for recording and analyzing the data of recruited subjects.
Results: During our study period, we have collected 100 cases as per inclusion criteria, in total collected 100 cases, 52% are male and 48% are female. The mean age and standard deviation of the study population were found to be 46.61±16.12. The most commonly prescribed classification before and after the surgery is cephalosporin’s that is 57%. Results show that in pre-surgery, almost 93% of prescriptions have chosen the drugs as per ASHP guidelines, whereas in post-surgery, 95% of drugs have selected the drug as per ASHP guidelines.
Conclusion: Our study has observed that some of the prescriptions are irrationally prescribed so the pharmacist has to take the responsibility to improve the awareness regarding rational prescribing of antibiotics. The national wide monitoring of antibiotics use, national schemes to obtain rational use of antibiotics, reassessing the prescriptions, education to practitioners, and surveys on antibiotics should be implemented.
STUDY ON RISK FACTORS, CLINICAL AND THERAPEUTIC PROFILE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS IN GOVERNMENT GENERAL HOSPITAL
Authors: P, SUCHARITHA J LAKSHMI , SINDHU M JAYA , TEJA A CHARAN , B MADHURI 
Published: March 2021

Objective: This study mainly aims to assess and evaluate risk factors, clinical and therapeutical profile in chronic obstructive pulmonary disease (COPD) patients and promote rational drug therapy; to identify the prevalence of COPD symptoms and to assess the drugs prescribed in treating COPD patients; and to evaluate patterns of diagnosing COPD in patients and determine the severity of COPD in patients using COPD assessment test (CAT).
Methods: A prospective observational study conducted in government general hospital among 220 patients for 6 months. Data were collected from patients by CAT questionnaire through interviewing each subject.
Results: The majority of the patients (36%) were in the age group of 71–80 years. Males are more prone to the COPD (91%). Most common initiation interdependence of these habits are 31–40 years and 61.8% are suffering with comorbidities. A total of 145 (65%) have social habits. About 68% of the patients are suffering from occupational exposure, 78% of the patients are suffering from old pulmonary problems.
Conclusion: Clinical pharmacist main provision is providing care to individual patients by patient counseling, regarding the rational usage of drug and also providing proper education regarding the usage of nebulizers and creating awareness to the patients.
A PROSPECTIVE STUDY OF SERUM FOLATE CONCENTRATION AND HEMOGLOBIN IN CERVIX CARCINOMA PATIENTS
Authors: KM SHANNO , SHARMA DISHA , MISHRA SUDHANSHU 
Published: March 2021

Objective: The study aimed to have a prospective study of serum folate concentration and hemoglobin (Hb%) in cervical carcinoma patients.
Methods: The study was conducted on women suffering from carcinoma cervix. The research was conducted in the Gynecological Outpatient Department (OPD) of the Oncology Unit in Mahavir Cancer Sansthan Patna, Bihar. The study period was from May 2016 to April 2017. The sample was collected after face to face interview by Figo staging and the sample was taken regularly. As a result strong association of Hb% and carcinoma cervix was found with the mean value of lower than 11.12, which is lower than the normal range of Hb%. As per the further estimation of folic acid, the level of cervical cancer is low.
Results: The data were estimated with help of tools such as SPSS 16.0 and PRISMA 5.0. The Hb% the mean value of patients was estimated to be lower than 11.12, which is not under the normal range of Hb%, that is, nearly 12.5 mg/dl. The low mean value shows less Hb% content which leads to anemia in normal beings as well as in patients with cervical cancer. A strong association of Hb% which affected to patients in carcinoma cervix can be seen in the graph that the mean value of patients low 11.12±0.20 which not comes under normal range of Hb%, that is, 12.5 mg/dl. The R square value is 0.9556.
Conclusion: As per our study, we have estimated that the folic acid level in cervical cancer is low. The -normal range of folic acid level in plasma serum is 2.2–20 ug/ml. The mean of 20 control cases, new cervical cancer patients, on treating patients, and follow-up patients is 11.08, 2.206, 3.554, and 2.783, respectively. The control 11.08 shows the better level in plasma serum level comes under a normal range of folic acid level.
IDENTIFICATION AND ANALYSIS OF DRUG-RELATED PROBLEMS INCIDENCE AT HOSPITALIZED PATIENTS IN HAJI REGIONAL GENERAL HOSPITAL, MAKASSAR
Authors: ALDILA SATRIA MUHAMMAD , SUPARDI SUDIBYO 
Published: March 2021

Objective: This study aims to identify inpatient medication problems and analyze the association between patient characteristics and the incidence of the drug-related problem (DRP) experienced by patients.
Methods: The cross-sectional study was conducted at Haji Regional General Hospital, Makassar, using medical record data for inpatients from January to February 2020. Data were collected from September to October 2020. A total of 247 inpatients were identified using the Indonesian version of the Pharmaceutical Care Network Europe.
Results: The most common DRP problem found is the effect of drug treatment not optimal (P1.2) by 35.76% and the most common cause found is no or incomplete drug treatment despite existing indication (C1.6) by 20.16%. Bivariate analysis shows that age, length of stay, and the number of drugs received are significant different with the incidence of DRP in patients (p < 0,01) respectively. Multivariate analysis using logistic regression shows that age, sex, and the number of drugs could significantly affect the incidence of DRP (p<0.05) with the r-square (R2) of 21.6%. According to this model, the largest odds ratio number and the most likely to experience DRP in a patient are age, the number of drugs, then gender (5,2; 4,6; and 2,3).
Conclusion: Age, length of stay, and the number of drugs received affect the DRP incidence in a patient, while gender together with age and the number of drugs affecting the incidence of DRP in a patient.
COMPARISON OF THE EFFECTS OF ANTIDEPRESSANTS ON COGNITION FUNCTIONS IN PATIENTS OF MAJOR DEPRESSIVE DISORDERS IN TERTIARY CARE HOSPITAL IN HARYANA
Authors: RANI SEEMA , SINDHU NITIKA , SAINI RAHUL , PANDEY A.K , NARWAT ARVIND , GARG SUNNY 
Published: March 2021

Objective: Depression is one of the most common mood disorders. Patients with major depressive disorder (MDD) usually present alterations in various cognitive functions. Several cost-effective interventions have shown favorable recovery and positive outcomes in the care and management of depression. The objective of the study was to compare the effect of fluoxetine (selective serotonin reuptake inhibitors), and venlafaxine (serotonin-norepinephrine reuptake inhibitors) on cognitive functioning in patients with MDD.
Methods: This prospective, single-blinded, randomized, and comparative interventional clinical study was conducted in a tertiary care hospital in Haryana. Fifty-two patients of MDD (ICD-10) were randomly divided into two groups: Group F and Group V, allocated to receive fluoxetine and venlafaxine, respectively. The assessment was done during the enrolment and at the end of the 3rd, 6th, 9th, and 12th weeks of treatment using the ABC-Hamilton Depression Rating Scale (HAM-D) and Montreal Cognitive Assessment (MoCA) Scale.
Statistical Analysis Used: The intragroup analysis was performed using repeated measures ANOVA while intergroup analysis was performed using unpaired “t”-test. p<0.05 was considered statistically significant.
Results: Mean HAM-D score was clinically as well as statistically significant at the end of the 12th week of treatment as compared to baseline in both the groups while on the intergroup comparison, there was no statistically significant difference in both groups. The mean MoCA score was (25±2.19) in Group F and (23.76±6.97) in Group V at the end of the 12th week. On intergroup analysis at the 12th week, a statistically significant improvement in cognitive functions was observed in patients Group F as compared to Group V (p<0.05).
Conclusions: The study of fluoxetine comparatively better improves cognition functions as compared to venlafaxine.
ADVERSE DRUG REACTION MONITORING AMONG HYPERTENSIVE PATIENTS OF TERTIARY CARE CENTER OF NORTH INDIA RELATED TO ANTIHYPERTENSIVE DRUGS
Authors: MISHRA SEEMA , AHMAD SYED S , NIGAM NILAM , SHANKAR PRATAP , KUMAR SHRAVAN , KUMAR VINAY , GUPTA SHALINI 
Published: March 2021

Objective: The objective of the study was to monitor the adverse drug reactions (A.D.Rs.) associated with antihypertensive drugs.
Methods: All patients coming to the department with blood pressure systolic above 120 mmHg and diastolic above 90 mmHg and prescribed hypertensives will be screened for the study.
Results and Discussion: A total of 136 patients were observed during the study. Out of 136 patients, 23 (17%) A.D.Rs. were recorded. A study conducted by Ramesh et al. in the Indian capital reports that 22.3% of the patients experienced A.D.Rs.
Conclusion: Furthermore, any appearance of A.D.Rs. due to side effects of the drugs or due to bad control and patients non-compliance, it was treated mainly by decreasing the doses of the drugs, switching them to another active substance from the same pharmacological group, or by adding more active substances from different pharmacological groups in lower dosages to achieve the B.P goals.
O processo judicial eletrônico no tribunal de justiça do distrito federal e dos territórios
Authors: Rabelo Tiago Carneiro 
Published: March 2021

Este artigo tem por escopo realizar uma análise que atravessa o Poder Judiciário, no tocante a sua
informatização, por meio do estudo da Lei 11.419 de 2006 (Lei de informatização do processo judicial),
que desenvolveu um novo paradigma processual com a inflexão de procedimentos eletrônicos aliado
aos recursos tecnológicos, em especial nas citações, intimações e na tramitação processual por meio
da rede mundial de computadores. Para tanto, será feita uma contextualização legal com o marco
histórico da implantação do sistema Processo Judicial Eletrônico (PJe), do Conselho Nacional de Justiça,
no âmbito do Tribunal de Justiça do Distrito Federal e dos Territórios, com vistas ao aprimoramento do
acesso à justiça, da celeridade processual e da sustentabilidade.
A cláusula penal nos contratos de incorporação imobiliária
Authors: Silva João Gabriel Ribeiro Pereira 
Published: March 2021

A regulamentação da resilição unilateral do contrato de compra e venda de imóveis submetido ao regime de
incorporação imobiliária prevista na Lei 13.786, de 27 de dezembro de 2018, não afasta o dever do Judiciário
de controlar a proporcionalidade da cláusula penal, mesmo que submetida aos limites previstos no novo
diploma legal. No presente trabalho, serão oferecidas ferramentas, para que o mencionado controle seja
feito de maneira objetiva, por meio da decomposição analítica dos elementos que constituem as perdas
ordinariamente advindas dessa modalidade de extinção contratual e da atribuição a elas do peso de 20%
sobre a totalidade da cláusula penal. Objetiva-se, com isso, disponibilizar critérios que ofereçam padrões
mais claros para a tomada de decisão, evitando-se o subjetivismo e as decisões contraditórias.
PENGARUH CITRA MEREK TERHADAP KEPUTUSAN PEMBELIAN PADA PT.ASTRA INTERNATIONAL, Tbk TOYOTA AUTO 2000 BUMI SERPONG DAMAI
Authors: Manik Cornelia Dumarya 
Published: March 2021

Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh citra merek terhadap keputusan pembelian pada PT. Astra International, Tbk-Toyota Auto 2000 cabang Bumi Serpong Damai. Penelitian ini dilaksanakan di PT. Astra International, Tbk-Toyota Auto 2000 cabang Bumi Srpong Damai. Model penelitian yang digunakan yakni dengan metode observasi, wawancara, kuesioner dan studi kepustakaan yang dilakukan secara sistematik berdasarkan tujuan penelitian. Metode penelitian ini menggunakan metode kuantitatif, asosiatif dengan populasi dalam penelitian ini adalah pelanggan yang melakukan service berkala pada PT. Astra International, Tbk-Toyota Auto 2000 cabang Bumi Serpong Damai, dalam waktu 5 (lima) tahun yaitu sebanyak 624 pelanggan. Metode penarikan sampel menggunakan rumus Slovin didapat sebanyak 86 responden. Metode analisis dalam pengolahan data adalah uji validitas dan reliabilitas, uji regresi linear sederhana, koefisien determinasi, uji hipotesis (uji-t), dan uji korelasi pearson product moment untuk mengetahui seberapa besar pengaruh citra merek terhadap keputusan pembelian mobil Toyota Yaris. Berdasarkan hasil penelitian dan pembahasan diperoleh hasil, bahwa terdapat pengaruh hubungan positif antara citra merek terhadap keputusan pembelian sebesar 0,602 sehingga adanya hubungan antara citra merek terhadap keputusan pembelian, dari hasil regresi lienar sederhana dapat dilihat persamaan yang bernilai y=16.546+0,583X. Yang memiliki arti bahwa variabel citra merek berpengaruh positif terhadap keputusan pembelian konsumen, dari hasil uji determinasi sebesar 0,362. Hal ini menunjukkan bahwa sebesar 36,2% Keputusan Pembelian konsumen terhadap pembelian mobil Toyota Yaris dipengaruhi oleh variasi dari ketiga variabel independen, yaitu keunggulan asosiasi merek, kekuatan asosiasi merek, keunikan asosiasi merek, Sedangkam sisanya sebesar 63,8% dipengaruhi oleh variabel-variabel lainnya yang tidak diteliti. Hasil t hitung adalah 6,907 lebih besar dari t tabel yaitu 1,9886. Oleh karena itu t-hitung lebih kecil daripada t-tabel, maka H0 ditolak dan Ha≠0 diterima. Ini menunjukkan bahwa antara pengaruh citra merek terhadap keputusan pembelian terdapat pengaruh yang signifikan.
PENGARUH PELATIHAN TERHADAP KINERJA KARYAWAN PADA PT. ELECTRONIC CITY CABANG BSD TANGERANG
Authors: Wardani Endang Susilo 
Published: March 2021

Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan terhadap kinerja karyawan pada PT. Electronick City Cabang BSD Tangerang. Metode yang digunakan adalah explanatory research dengan sampel sebanyak 52 responden. Teknik analisis menggunakan analisis statistik dengan pengujian regresi, korelasi, determinasi dan uji hipotesis. Hasil penelitian ini variabel pelatihan diperoleh nilai rata-rata skor sebesar 3,787 dengan kriteria baik. Variabel kinerja karyawan diperoleh nilai rata-rata skor sebesar 3,825 dengan kriteria baik. Pelatihan berpengaruh positif dan signifikan terhadap kinerja karyawan dengan nilai persamaan regresi Y = 13,866 + 0,644X, dan nilai koefisien korelasi 0,771 atau memiliki tingkat hubungan yang kuat dengan nilai determinasi 59,5%. Uji hipotesis diperoleh signifikansi 0,000 < 0,05.
KONTRIBUSI TINGKAT RELIGIUSITAS DAN PROMOSI TERHADAP MINAT MASYARAKAT MENJADI NASABAH
Authors: Sjahruddin Herman , Ardiansyah Resky , Themba Orfiyanni Syarfetti , Tenriola Andi 
Published: March 2021

Penelitian ini bertujuan untuk menguji kontribusi tingkat religiusitas dan promosi terhadap minat masyarakat menjadi nasabah. Populasi dalam penelitian ini adalah Nasabah PT. Bank BNI Syariah (Persero) Tbk Cabang Makassar. Jumlah sampel sebanyak 49 yang diperoleh dengan menggunakan Nonprobability sampling. Untuk mencapai tujuan dalam penelitian ini menggunakan metode analisis regresi linier berganda SPSS Ver. 22. Nilai t-statistik memberikan bukti jika tingkat religiusitas yang dimiliki nasabah dan promosi yang dilakukan pihak manajemen bank terbukti memberikan kontribusi yang positif dan signifikan terhadap peningkatan minat masyarakat menjadi nasabah.