bluuebunny/crossref_metadata_2025_split huggingface dataset:
he omega-3 and Nano-curcumin effects on vascular cell adhesion molecule (VCAM) in episodic migraine patients: a randomized clinical trial
Authors: Abdolahi Mina , Karimi Elmira , Sarraf Payam , Tafakhori Abbas , Siri Goli , Sedighiyan Mohsen , Asanjarani Behzad , Djalali Mahmoud , Badeli Mostafa , Abdollahi Hamed , Yoosefi Niyoosha , Abdullah Hakima , Shayegan Amir 
Published: April 2021

Abstract
Objective
The purpose of this clinical trial was to examine the effect of omega-3 fatty acids (W-3 FAs), nanocurcumin and their combination on serum levels and gene expression of VCAM in patients with episodic migraine.
Results
In this study, 80 patients were randomly divided in to 4 groups to receive for 2 months. Both serum levels and gene expression of VCAM showed remarkable decreases after single W-3 and after combined W-3 and nanocurcumin interventions. However, a borderline significant change and no remarkable change were observed after single nanocurcumin supplementation and in control group, respectively. While a significant difference between study groups in VCAM concentrations existed, there was no meaningful difference in VCAM gene expression among groups. It appears that the W-3 and combined W-3 and nanocurcumin can relieve VCAM serum level and its gene expression in patients with episodic migraine. Moreover, the combination of W-3 with nanocurcumin might cause more significant declines in VCAM level in the serum of migraine patients than when W-3 is administered alone.
Remote Patient Monitoring and classifying Using the Internet of Things Platform Combined with Cloud Computing
Authors: Iranpak Somayeh , Shahbahrami Asadollah , Shakeri Hassan 
Published: April 2021

Abstract
Patients' health and providing an optimal and appropriate solution have recently been considered by many researchers. With the advent of technologies such as cloud computing and 5G network, information can be exchanged faster and more securely. Using cloud computing in this process can significantly improve the monitoring of certain patients. Therefore, providing a favorable method in the medical industry and computer science to monitor the status of patients using connected sensors is very important. Thus, due to its optimal efficiency, speed, and accuracy of data processing and classification, the use of cloud computing to process the data collected from remote patient sensors and the Internet of Things (IoT) platform has been suggested. In this paper, a prioritization system is used to prioritize sensitive information in IoT, and in cloud computing, LSTM deep neural network is used to classify and monitor patients' condition remotely, which can be considered as an important innovative aspect of this paper. Sensor data in the IoT platform is sent to the cloud with the help of the 5th generation Internet. The core of cloud computing uses the LSTM deep neural network algorithm. Through simulating the proposed method and comparing the obtained results with other methods, it was observed that the accuracy of the proposed method has been improved significantly compared to other methods.
Copepod Production in Warm, Oil Polluted Environment: A Laboratory Investigation of Temora stylifera (Dana, 1849) Adapted to the Gulf of Guinea
Authors: Asiedu Delove , Acheampong Emmanuel , Asare Noble 
Published: April 2021

Abstract
Recent studies suggests that sea surface warming, evidently caused by greenhouse gas emissions, magnifies the toxicity of petroleum hydrocarbons on marine copepods. We assessed this understanding using Temora stylifera, a calanoid copepod common in the Atlantic Ocean and its surrounding waters, as a case study. The copepod was exposed to moderate (0.2 μg.l-1) and high levels (2.0 μg.l-1) of pyrene under three warming scenarios: (i) a no warming control at 28 °C, the surface temperature of the Gulf of Guinea during stable hydrographic period, (ii) moderate warming (+2 °C) and (iii) severe warming (+4 °C) above the control. Food ingestion rate of the copepod increased with warming without significant effect from the pollutant. Feacal pellet production rate (FP) increased by about 86% when the animal was exposed to moderate warming and pyrene at the same time, signifying reduced assimilation of food ingested in these conditions. Lowest FP (3.5 ± 1.1 copepod-1.day-1) indicating increased food assimilation occurred when the stressors were presented either alone or together. Egg production rate and efficiency of the copepod were impacted by only warming, decreasing by ≈60% under both warming scenarios, consistent with previous observations. Mortality rate increased by ≈ 40 % when pyrene pollution was elevated from nought to the highest level. It did not change significantly with temperature, suggesting warming did not exacerbate the lethal effect of pyrene to T. stylifera. These results are contrary to observations on other copepods and highlight the unique responses of Temora to sea surface warming and petroleum pollution.
Development a Nomogram for Predicting Intrahepatic Cholangiocarcinoma in Patients with Biliary Calculi after Surgery
Authors: Chen Junyu , Zhou Wangxin , Zhu Xiandong , Tang Yinhe , Wang Haibiao , Wu Lijun , Li Hong 
Published: April 2021

Abstract
Objective: To find out the risk factors of intrahepatic cholangiocarcinoma ( ICC ) in patients who underwent biliary surgery for biliary calculi, and to develop a nomogram to better predict the occurrence of ICC.Methods: Data were collected and analyzed retrospectively from 322 patients who underwent biliary tract surgery for biliary calculi in the First Affiliated Hospital of Wenzhou Medical University from January 2000 to December 2017.Of these patients, 58 patients had biliary calculi complicated with ICC while the other 294 patients had simple biliary calculi. Both univariate and multivariate analyses were performed to find out the risk factors related to ICC, and a nomogram was further developed based on the results of multivariate analysis.Results: The univariate analysis showed that there were significant differences in age composition (≤ 60 years old, > 60 years old), liver cirrhosis, stone history and previous hepatitis B infection (HBsAg- and HBcAb+) between the two groups. Logistic regression analysis indicated that liver cirrhosis (OR=2.011, 95%CI=1.023-3.952), stone history (OR=1.086, 95%CI=1.051-1.112) and age > 60 (OR=2.045, 95%CI=1.059-3.948) were the risk factors of ICC, while previous hepatitis B infection (HBsAg- and HBcAb+) (OR=0.461, 95%CI=0.215-0.989) was the protective factor. After drawing a nomogram, it was found that the area under the curve was 0.753 (95% CI=0.686-0.818), and the best cutoff value obtained by Youden index was 0.164. Moreover, the calibration curve indicated the best consistency between the predicted probability and the actual probability.Conclusion: We developed a nomogram, which was novel and accurate, to predict the risk of ICC in patients received biliary surgery for biliary calculi. This nomogram is of certain significance for the early detection of ICC.
Survival of animal and human-associated Listeria monocytogenes in drinking water and biofilms
Authors: Bjergbæk Louise Appel , Hesselsoe Martin , Pagh Sussie , Roslev Peter 
Published: April 2021

Abstract
Land slugs are occasionally observed as contaminants in groundwater wells and drinking water treatment plants including storage tanks. Slugs may feed on carrion and feces, and they are potential vectors of pathogens such as Listeria monocytogenes. We isolated L. monocytogenes from the pest slug Arion vulgaris and examined the persistence and survival of human- and slug-derived L. monocytogenes in groundwater-based drinking water and biofilms. L. monocytogenes survival was evaluated using cultivation and cultivation-independent techniques. L. monocytogenes remained culturable for 35–47 days in drinking water with first-order decay rates between 0.314 and 0.457 h−1 (T99 ≥10 days). Attachment of L. monocytogenes to filter sand delayed washout from drinking water filters and increased persistence 2–3-fold. Indigenous biofilms stimulated initial surface attachment 10–100-fold but L. monocytogenes declined more rapidly in drinking water biofilms compared with virgin filters not colonized by microorganisms. Grazing by protozoa likely attenuated L. monocytogenes survival in some drinking water biofilms. A comparable survival pattern was observed for L. monocytogenes and the fecal indicator bacterium E. coli. The study suggests that live L. monocytogenes can persist for weeks as sessile organisms in groundwater-based drinking water supplies and may subsequently be released to the drinking water.
Study of the effect of the LDH cations precursors in the removal of arsenic in aqueous solution
Authors: Quiroga María Martha Barroso , Juncà Mònica Iglesias , Merino Nora Andrea 
Published: April 2021

Abstract
Layered double hydroxides (LDH) are anionic clays, mainly used as adsorbents, ion exchange material, and catalysts. Generally, they present high specific surface areas, alkaline character, high metallic dispersion, and high thermal stability. If they contain a transitional element in their structure, the solid may present redox properties. LDH were synthesized with the following combinations: MgAl, MgFe, and ZnMgFe, aiming to determine the effect of cationic nature in the structure and the functionality of the synthesized clay as adsorbents in polluted aqueous effluents. The textural properties were determined by nitrogen adsorption isotherms. Crystalline structure was studied by XRD and the presence of the anions of the interlayer was determined by FTIR spectroscopy. The studies of removal of As(III) and As(V) from aqueous solutions, using the LDH, show that after 24 h the solids reach a high removal efficiency. ZnMgFe solid removed both species of arsenic with values of 95 and 98% for As(II) and As(V), respectively. The MgFe solid showed some selectivity to the uptake of As(V), while the MgAl only removed As(V). This selective behaviour can be beneficial in studies of arsenic speciation.
Regulatory Roles of the Notch Signaling Pathway in Liver Repair and
Regeneration: A Novel Therapeutic Target
Authors: Valizadeh Amir , Sayadmanesh Ali , Asemi Zatollah , Alemi Forough , Mahmoodpoor Ata , Yousefi Bahman 
Published: April 2021

:
The liver is one of the significant regenerative organs in the body. Nevertheless,
underlying molecular mechanisms regulating liver repair and regeneration following
resection or damage remain largely unknown. The Notch signaling pathway is a profoundly
evolutionarily well-conserved cell signaling system that mostly involves developing
multicellular organisms. Malfunctions in this pathway lead to the progression of several
liver disorders, including hepatoblastoma (HB), cholangiocarcinoma (CCA) and hepatocellular
carcinoma (HCC). The Notch pathway plays a fundamental role in cell fate
during the embryonic stage's progression to the adult stage in liver tissue. Modulation of
Notch signaling may be used in many patients who succumb to cirrhosis due to chronic
hepatitis by virus infection. This review describes the underlying mechanisms of the
Notch signaling pathway in liver development and regeneration briefly and discusses
how this pathway leads to the betterment of liver disorders in the clinic.
Intravesical Blood Clot Retention? How We Manage It, a Tertiary Hospital Preference
Authors: Laksita Tetuka Bagus , Rizaldi Fikri 
Published: April 2021

Intravesical blood clot retention is one of the Urological emergencies. Ongoing haematuria and blood clot formation in the bladder obstruct the urine outflow and lead to urinary retention, abdominal pain, anemia, urinary tract infection (UTI), and renal function deterioration. Most of the cases required cystoscopy blood clot evacuation and definitive surgery to stop the ongoing bleeding. This study aimed to discover the demography, characteristics, management, and complication of patients with intravesical blood clot retention in Dr. Soetomo General Acadenic Hospital, Surabaya from January 2017 until April 2020. This is an observational study, a retrospective-descriptive design. We conducted a review on the medical records of 97 patients, 76 males and 21 females with an average age of 54.9 years old. Of all patients initially treated conservatively using normal saline irrigation with a large three-way catheter (22-24 fr), four were successfully treated without surgery, and 89 patients underwent cystoscopy and definitive surgery. The mean operation time was 69,6 minutes, with an average blood clot volume of 167,7 ml (25-600 ml). Sources of bleeding were mostly originated from malignancy (58%), Benign Prostatic Hyperplasia (BPH) (10%), and hemorrhagic cystitis (7%).Â The most common comorbidity found was hypertension (13) and chronic kidney disease (10). Based on our experience, managing intravesical blood clot retention with cystoscopy continued with definitive surgery in a one-step procedure is a good approach. Urological malignancy is the most frequent abnormality that causes intravesical blood clot retention.
Parents’ Attitudes Toward School Students’ Overuse of Smartphones and Its Detrimental Health Impacts: Qualitative Study
Authors: Buabbas Ali , Hasan Huda , Shehab Abrar Abdulmohsen 
Published: April 2021

Background
Parents’ awareness of the risks of the overuse of smartphones (SPs) among their children and parents’ attitudes toward this societal phenomenon are crucial factors to consider when investigating the causes and effects of, as well as interventions to control, this public health issue.

Objective
This study aimed to explore the awareness and attitudes of parents regarding SP overuse among their children and the detrimental impacts associated with it.

Methods
The qualitative method of semistructured face-to-face interviews was used to collect data from fathers and mothers of children aged 6-18 years from all 6 educational/governorate regions in the governmental sector in Kuwait.

Results
A total of 120 parents agreed to participate in the study; there were more female (75/120, 62.5%) than male (45/120, 37.5%) respondents. Almost all of the participants (118/120, 98.3%) were aware that the overuse of SPs could lead to their children becoming addicted to the devices; they were also aware that there could be side effects on their children’s health (117/120, 97.5%). Although the participants, mostly the mothers, supervised their children’s use of SPs closely (106/120, 88.3%), the majority could not control their children’s length of time using SPs, as the children considered this a deprivation of their rights. Eye-related problems, headaches, and anger were the most common side effects experienced by the children.

Conclusions
Although the parents were aware of the detrimental impacts of SP overuse, the majority could not control the length of time their children spent using the devices. It was found that strong social bonds among family members play a large role in controlling the use of SPs. A number of solutions for families and the government to combat the overuse of SPs are suggested.
App-Based Feedback for Rehabilitation Exercise Correction in Patients With Knee or Hip Osteoarthritis: Prospective Cohort Study
Authors: Biebl Johanna Theresia , Rykala Marzena , Strobel Maximilian , Kaur Bollinger Pawandeep , Ulm Bernhard , Kraft Eduard , Huber Stephan , Lorenz Andreas 
Published: April 2021

Background
The use of digital therapeutic solutions for rehabilitation of conditions such as osteoarthritis provides scalable access to rehabilitation. Few validated technological solutions exist to ensure supervision of users while they exercise at home. Motion Coach (Kaia Health GmbH) provides audiovisual feedback on exercise execution in real time on conventional smartphones.

Objective
We hypothesized that the interrater agreement between physiotherapists and Motion Coach would be noninferior to physiotherapists’ interrater agreement for exercise evaluations in a cohort with osteoarthritis.

Methods
Patients diagnosed with osteoarthritis of the knee or hip were recruited at a university hospital to perform a set of 6 exercises. Agreement between Motion Coach and 2 physiotherapists’ corrections for segments of the exercises were compared using Cohen κ and percent agreement.

Results
Participants (n=24) were enrolled and evaluated. There were no significant differences between interrater agreements (Motion Coach app vs physiotherapists: percent agreement 0.828; physiotherapist 1 vs physiotherapist 2: percent agreement 0.833; P<.001). Age (70 years or under, older than 70 years), gender (male, female), or BMI (30 kg/m2 or under, greater than 30 kg/m2) subgroup analysis revealed no detectable difference in interrater agreement. There was no detectable difference in levels of interrater agreement between Motion Coach vs physiotherapists and between physiotherapists in any of the 6 exercises.

Conclusions
The results demonstrated that Motion Coach is noninferior to physiotherapist evaluations. Interrater agreement did not differ between 2 physiotherapists or between physiotherapists and the Motion Coach app. This finding was valid for all investigated exercises and subgroups. These results confirm the ability of Motion Coach to detect user form during exercise and provide valid feedback to users with musculoskeletal disorders.
Pengaruh Edukasi Apoteker Terhadap Tahap Berhenti Merokok pada Mahasiswa Perokok Aktif Tahap Contemplation
Authors: Siswati Siswati , Sarniatnto Prih , Andayani Nurita 
Published: April 2021

Kebiasaan merokok merupakan salah satu kebiasaan tidak sehat yang potensial menimbulkan penyakit kronis, seperti Diabetes Melitus tipe 2, penyakit kardiovaskular, penyakit jantung koroner, kanker paru dan penyakit pernafasan kronis. Masih banyaknya mahasiswa yang merokok, memerlukan pendekatan seperti adanya edukasi apoteker terhadap upaya berhenti merokok. Perilaku berhenti merokok terbagi menjadi beberapa tahapan, yaitu: tahap pre-contemplation, contemplation, preparation, action, maintenance dan relapse. Pada tahap contemplation, perokok telah berfikir serius untuk berhenti merokok. Intervensi edukasi oleh apoteker sebagai salah satu tenaga kesehatan, terutama pada perokok yang berada pada tahap contemplation merupakan hal penting yang dapat menunjang keberhasilan upaya berhenti merokok,sehingga mahasiswa perokok dapat berada pada tahap selanjutnya dari tahap contemplation. Penelitian ini memiliki desain studi quasi eksperimental pre-test dan post test dan pengumpulan data menggunakan metode purposive sampling. Penelitian ini bertujuan untuk mengetahui pengaruh edukasi apoteker terhadap perilaku berhenti merokok pada mahasiswa perokok aktif tahap contemplation. Dengan responden 43 mahasiswa perokok aktif tahap contemplation, hasil penelitian diuji dengan uji t one pair, untuk melihat pengaruh edukasi apoteker terhadap perilaku berhenti merokok. Hasil penelitian menunjukkan, edukasi apoteker memberikan perubahan yang bermakna pada nilai Urica Scale tahap perilaku berhenti merokok, namun tidak merubah tahap berhenti merokok responden, dimana sebelum edukasi adalah contemplation, sesudah edukasi juga tetap berada di tahap contemplation.
Eksplorasi Pendugaan Hara Daun Tanaman Kelapa Sawit Menggunakan Pesawat Tanpa Awak dan Kamera Multispektral
Authors: Santoso Heri , Winarna Winarna 
Published: April 2021

Rekomendasi pemupukan umumnya disusun setiap tahun untuk mengkoreksi kebutuhan hara tanaman melalui kegiatan pemupukan. Hara daun dalam penyusunan rekomendasi pemupukan merupakan bagian kecil dari beberapa parameter yang digunakan. Beberapa peneliti telah melakukan prediksi hara daun tanaman kelapa sawit memanfaatkan data satelit multispektral dan pengukuran spectroradiometer dengan hasil yang bervariasi. Penelitian prediksi hara daun kelapa sawit dengan pesawat tanpa awak dan kamera multispektral ini dilakukan karena belum ada kajian mengenai penggunaan teknologi tersebut untuk prediksi hara daun kelapa sawit. Tujuan penelitian ini adalah membandingkan performa pendugaan hara daun dari berbagai variasi komposisi variabel berupa 3 saluran dan beberapa indeks vegetasi, serta untuk menentukan analisis regresi terbaik. Band hijau, merah, dan inframerah dekat dari kamera multispektral Mapir Survey 3, serta indeks vegetasi simple ratio, normalized difference vegetation index, dan green NDVI digunakan sebagai variabel bebas dalam analisis regresi sederhana, regresi polinomial, regresi berganda dari variabel terseleksi dengan teknik recursive feature elimination dengan metode regresi linear dan random forest, dan regresi berganda polinomial dengan variabel tidak bebas (respons) berupa analisis daun dari 20 sampel yang meliputi hara N, P, K, Ca, Mg, dan B. Model penduga terbaik dari penelitian ini adalah model regresi berganda polinomial dari variabel terseleksi menggunakan teknik RFE metode random forest. Variabel bebas hanya mampu menduga hara daun N, P, K, dan Mg dengan nilai R2 sebesar 0,9415 hingga 0,9991, Adjusted R2 sebesar 0,7223 hingga 0,9837, serta nilai residual standard error (RSE) sebesar 0,0045 hingga 0,0340.
Estrategias didácticas a través de la realidad mixta para el aprendizaje teórico-práctico en estudiantes de educación media superior
Authors: Encarnación De Jesús Laura , Ayala Ramírez Suhey 
Published: April 2021

Por las características que presenta, la realidad mixta es una tecnología prometedora dentro del sector educativo. El objetivo de esta investigación fue evaluar la influencia que tiene esta tecnología en el aprendizaje teórico-práctico de estudiantes de educación media superior. El enfoque fue de carácter mixto. Se apoyó de un pretest y postest para evaluar aprendizajes específicos de arquitectura de hardware. Asimismo, se apoyó de las aplicaciones Creator AVR y PC Building. Para evaluar la influencia de la realidad mixta, se utilizó el modelo de aceptación de tecnologías que evalúa los rubros de facilidad, usabilidad y utilidad. Como resultado general, se obtuvo 79.2 % de conocimientos teóricos-prácticos. En el indicador de utilidad, se obtuvo 87 %, en el de usabilidad 69 % y en el de facilidad de uso 65 %. El estudio permitió observar que el uso de la realidad mixta puede apoyar el aprendizaje teórico-práctico de los estudiantes.