bluuebunny/crossref_metadata_2025_split huggingface dataset:
YB1 regulates miR‐205/200b‐ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma
Authors: Liu Xiumei , Chen Di , Chen Huan , Wang Wen , Liu Yu , Wang Yawei , Duan Chao , Ning Zhen , Guo Xin , Otkur Wuxiyar , Liu Jing , Qi Huan , Liu Xiaolong , Lin Aifu , Xia Tian , Liu Hong‐xu , Piao Hai‐long 
Published: June 2021

AbstractBackgroundY‐box binding protein 1 (YB1 or YBX1) plays a critical role in tumorigenesis and cancer progression. However, whether YB1 affects malignant transformation by modulating non‐coding RNAs remains largely unknown. This study aimed to investigate the relationship between YB1 and microRNAs and reveal the underlying mechanism by which YB1 impacts on tumor malignancy via miRNAs‐mediated regulatory network.MethodsThe biological functions of YB1 in hepatocellular carcinoma (HCC) cells were investigated by cell proliferation, wound healing, and transwell invasion assays. The miRNAs dysregulated by YB1 were screened by microarray analysis in HCC cell lines. The regulation of YB1 on miR‐205 and miR‐200b was determined by quantitative real‐time PCR, dual‐luciferase reporter assay, RNA immunoprecipitation, and pull‐down assay. The relationships of YB1, DGCR8, Dicer, TUT4, and TUT1 were identified by pull‐down and coimmunoprecipitation experiments. The cellular co‐localization of YB1, DGCR8, and Dicer were detected by immunofluorescent staining. The in vivo effect of YB1 on tumor metastasis was determined by injecting MHCC97H cells transduced with YB1 shRNA or shControl via the tail vein in nude BALB/c mice. The expression levels of epithelial to mesenchymal transition markers were detected by immunoblotting and immunohistochemistry assays.ResultsYB1 promoted HCC cell migration and tumor metastasis by regulating miR‐205/200b‒ZEB1 axis partially in a Snail‐independent manner. YB1 suppressed miR‐205 and miR‐200b maturation by interacting with the microprocessors DGCR8 and Dicer as well as TUT4 and TUT1 via the conserved cold shock domain. Subsequently, the downregulation of miR‐205 and miR‐200b enhanced ZEB1 expression, thus leading to increased cell migration and invasion. Furthermore, statistical analyses on gene expression data from HCC and normal liver tissues showed that YB1 expression was positively associated with ZEB1 expression and remarkably correlated with clinical prognosis.ConclusionThis study reveals a previously undescribed mechanism by which YB1 promotes cancer progression by regulating the miR‐205/200b‒ZEB1 axis in HCC cells. Furthermore, these results highlight that YB1 may play biological functions via miRNAs‐mediated gene regulation, and it can serve as a potential therapeutic target in human cancers.
Clinicopathological features and lymph node and distant metastasis patterns in patients with gastroenteropancreatic mixed neuroendocrine‐non‐neuroendocrine neoplasm
Authors: Zhang Panpan , Li Zhongwu , Li Jie , Li Jian , Zhang Xiaotian , Lu Zhihao , Sun Yu , Li Yan , Zhou Jun , Wang Xicheng , Peng Zhi , Shen Lin , Lu Ming 
Published: June 2021

AbstractObjectiveOwing to its rarity and heterogeneity, the biological behavior and optimal therapeutic management of mixed neuroendocrine‐non‐neuroendocrine neoplasm (MiNEN) have not been established. Herein, we aimed to evaluate the clinicopathological characteristics and metastatic patterns of MiNEN.MethodsContinuous clinicopathological data of MiNEN patients treated at our hospital were retrospectively collected and analyzed.ResultsThis study had enrolled 169 patients since January 2010 to January 2020. Pathological components were assessed in 129 patients with MiNEN (76.3%), and a focal (non‐)neuroendocrine component was observed in 40 patients (23.7%; <30% of the tumor). Among the enrolled patients, 80 underwent surgical removal of the primary tumor and lymph nodes (LNs), and 34 with distant metastasis underwent biopsy of both primary tumor and metastatic lesions. In patients with LN metastasis, 68.8% (55/80) exhibited a pure component of either neuroendocrine (NE) or adenocarcinoma/squamous carcinoma (AS) in metastatic LNs, while 20% (16/80) showed different components in different LNs, and only 11.2% (9/80) exhibited both NE and AS components in the same LN. In patients with distant metastases, 26.5% (9/34) possessed coexisting NE and AS components in the distant metastases, 70.6% (24/34) were regarded as a pure NE component, and 2.9% (1/34) were comprised of a pure AS component.ConclusionLymph node and distant metastases exhibited distinct metastatic patterns in patients with MiNEN. The major pathological component in regional LNs may have influenced the proportion of the two components within the primary tumor, but distant metastases were dominated by the NE component.
Open‐wedge high tibial osteotomy for the treatment of osteoarthritis of both knee and ankle in the same leg: A report of two cases
Authors: Baek Ji‐Hoon , Lee Su Chan , Jin Hosun , Ahn Hye Sun , Nam Chang Hyun 
Published: June 2021

AbstractWe report two cases of patients with concurrent osteoarthritis of the knee and ipsilateral ankle. The patients were treated with high tibial osteotomy (HTO). In well‐planned and selected cases, HTO may be effective in treating not only the knee, but also the ankle in patients with ipsilateral double‐joint osteoarthritis.
Inappropriate prescription of corticosteroid therapy during inflammatory ileo‐colitis revealing disseminated tuberculosis with digestive involvement: Two case reports
Authors: Razafindrazoto Chantelli Iamblaudiot , Randriamifidy Nitah Harivony , Rakotomalala Jolivet Auguste , Ralaizanaka Behoavy Mahafaly , Rakotomaharo Mialitiana , Hasina Laingonirina Domoina Harivonjy , Maherison Sonny , Rasolonjatovo Anjaramalala Sitraka , Rakotozafindrabe Andry Lalaina Rinà , Rabenjanahary Tovo Harimanana , Razafimahefa Soloniaina Hélio , Ramanampamonjy Rado Manitrala 
Published: June 2021

AbstractIt is essential to differentiate intestinal tuberculosis from Crohn's disease because of the therapeutic implications of Crohn's disease, which can exacerbate the symptoms of tuberculosis.
Response to pegylated interferon in a COVID‐19 positive male with metastatic jejunal neuroendocrine tumor treated with everolimus
Authors: Frankel Arthur E. , Yip Wai C. , Naik Eknath , Hasselbalch Hans C. 
Published: June 2021

AbstractA 61‐year‐old male on everolimus had chronic SARS‐CoV‐2 infection. Addition of pegylated interferon cleared viral RNA and supports combination therapy with everolimus plus interferon for COVID‐19.
A rare case of Levofloxacin‐related Iliopsoas and Achilles tendon rupture
Authors: Bedi Prabhjot Singh , Kuriakose Kiran , Kim Jay , Lewis Paul B , Singh Vikas K 
Published: June 2021

AbstractAchilles tendon rupture is a well‐documented adverse effect of Fluoroquinolones; however, herein we present a case of complete iliopsoas and Achilles, and partial semimembranosus tendon rupture secondary to Levofloxacin.
Chest imaging of hypersensitivity pneumonitis induced by heroin abuse
Authors: Bond Michael C. , Butler Kenneth H. , Richardson Adam C. , Blosser Kelly M. 
Published: June 2021

AbstractLong‐term abuse of nasally inhaled substances such as heroin can result in life‐threatening hypersensitivity pneumonitis and respiratory distress. In the setting of hypoxia, a chest CTA is often necessary to see the extent of the lung involvement and to rule out pulmonary emboli.
Electrochemical and Plasmon‐induced Grafting of n‐Dopable π‐Conjugated Oligomers
Authors: Bastide Mathieu , Frath Denis , Gam‐Derouich Sarra , Lacroix Jean‐Christophe 
Published: June 2021

AbstractThe functionalization of electrodes by the reduction of diazonium cations generated in situ from 4‐(2,3‐diethylthieno[3,4‐b]pyrazine‐5‐yl)aniline has been investigated. The thienopyrazine unit of this molecule is a precursor of n‐dopable π‐conjugated oligomers. Electrochemical reduction of diazonium cation coats the electrode with organic layers. Raman, IR, and XPS analyses show that their composition corresponds to that of the starting monomer, while AFM scratching measurements indicate thicknesses below 10 nm. The electrochemical responses of various reversible redox couples on the modified electrodes show that the attached layer is insulating in the positive potential range but can be n‐doped at negative potential and switches to a conductive state. Moreover, oligo(4‐(2,3‐diethylthieno[3,4‐b]pyrazine‐5‐yl)phenyl) can be selectively grafted onto gold nanoparticles (AuNPs) by plasmon‐induced diazonium reduction. A 10–20 nm‐thick organic layer is easily grafted onto each gold nanoparticle by visible‐light illumination in a few minutes without any reducing agent or molecular photocatalyst. This result is attributed to the transfer of hot electrons from the excited plasmonic NPs to the diazonium, confirms that localized surface plasmon resonance can induce nanolocalized electrochemical reactions, and contributes to the emerging field of “plasmonic electrochemistry”.
Host‐Guest Interaction in Ethylene and Ethane Separation on Zeolitic Imidazolate Frameworks as Revealed by Solid‐State NMR Spectroscopy
Authors: Xiao Yuqing , Chu Yueying , Li Shenhui , Chen Fang , Gao Wei , Xu Jun , Deng Feng 
Published: June 2021

AbstractThe separation of ethane/ethylene mixture by using metal‐organic frameworks (MOFs) as adsorbents is strongly associated with the pore size‐sieving effect and the adsorbent‐adsorbate interaction. Herein, solid‐state NMR spectroscopy is utilized to explore the host‐guest interaction and ethane/ethylene separation mechanism on zeolitic imidazolate frameworks (ZIFs). Preferential access to the ZIF‐8 and ZIF‐8‐90 frameworks by ethane compared to ethylene is directly visualized from two‐dimensional 1H‐1H spin diffusion MAS NMR spectroscopy and further verified by computational density distributions. The 1H MAS NMR spectroscopy provides an alternative for straightforwardly extracting the adsorption selectivity of ethane/ethylene mixture at 1.1∼9.6 bar in ZIFs, which is consistent with the IAST predictions.
A Facile Construction of Bisheterocyclic Methane Scaffolds through Palladium‐Catalyzed Domino Cyclization
Authors: Qi Hongbo , Han Kaiming , Chen Shufeng 
Published: June 2021

Main observation and conclusionA convenient palladium‐catalyzed domino cyclization reaction for the construction of bis(benzofuranyl)methane scaffolds bearing an all‐carbon quaternary center has been described. In the cascade process, one C(sp2)—O bond, two C(sp2)—C(sp3) bonds as well as two benzofuran rings are formed in a single synthetic sequence. The approach shows wide scope of substrates and good functional‐group tolerance. Moreover, this methodology is successfully extended to the synthesis of benzofuranyl methyl chromane derivatives.
Autophagy‐Dependent Ferroptosis as a Therapeutic Target in Cancer
Authors: Liu Li , Li Liqi , Li Menghuan , Luo Zhong 
Published: June 2021

AbstractFerroptosis is an iron‐dependent form of cell death associated with the accumulation of labile iron and cytotoxic lipid peroxides. Increasing evidence reveals that ferroptosis is not a self‐standing phenomenon and has close connections with other cellular events. Remarkably, recent insights show that ferroptosis is dependent on autophagy, which is a lysosomal degradation pathway responsible for the recycling of damaged cellular components under survival stress. Autophagy is capable of contributing to ferroptosis through degradation of the ferritin, an iron‐storage protein, accompanied with the accumulation of iron levels and lipid ROS. The interplay between autophagy and ferroptosis also reveals emerging opportunities for novel tumor therapies, which has inspired the development of many treatment strategies capable of inducing ferroptosis in tumor cells via autophagic pathways based on molecular and nanoparticulate agents. In this review, we summarize the specific molecular and regulatory networks of autophagy‐dependent ferroptosis and highlight their pathophysiological impact on various aspects of tumor cells. A perspective was also provided regarding the preliminary therapeutic exploitation of ferroptosis/autophagy crosstalk for tumor treatment.
A variant of teaching‐learning‐based optimization and its application for minimizing the cost of Workflow Execution in the Cloud Computing
Authors: Ram Satya Deo K. , Srivastava Shashank , Kumar Mishra Krishn 
Published: June 2021

AbstractTeaching learning‐based optimization (TLBO) was proposed by Rao to solve optimization problems. It is based on the theory of teaching‐learning mechanism. Although it performs well in unimodal problems yet its performance is not good in multimodal problems. To further improve this algorithm's performance and make it suitable for both unimodal problems and multimodal problems, we made some major changes in the theory and the algorithm's operators. The proposed algorithm is able to capture diverse optimal solutions in less number of iterations and is very good for solving multimodal problems. This newly created variant of TLBO is named generalized TLBO (GTLBO). The performance of GTLBO is tested on CEC−06, 2019 benchmark functions and other 15 classical benchmark functions, and it is found that the proposed algorithm is performing better comparatively. Then it is simulated for solving the workflow scheduling problem in CloudSim. Standard scientific workflow applications as Montage, Epigenomics, Sipht, and a sample workflow are used as dataset to test algorithms' performance in cloud environments. Our proposed approach, GTLBO, provides the proper distribution of workloads and offers minimal execution‐cost for the workflow applications. Results reflect the supremacy of the proposed algorithm GTLBO comparatively.
General mentalizing, emotional theory of mind and interpersonal mistrust in anorexia nervosa: The validation of the Hebrew version of the Cambridge mindreading face‐task
Authors: Rothschild‐Yakar Lily , Goshen Dor , Enoch‐Levy Adi , Raanan Hadas , Gur Eitan , Stein Daniel , Golan Ofer 
Published: June 2021

AbstractObjectiveThis study had two goals. The first was to validate and examine the potential of the Hebrew version of the Cambridge Mindreading face task (CAMHeb)—an ecological measure of emotional theory of mind (eToM)—to assess eToM in individuals with anorexia nervosa (AN). The second goal was to examine whether interpersonal mistrust would mediate the relation between mentalizing and eToM and the severity of AN.MethodThe validity of the CAMHeb was examined using well‐established measures of mentalizing ability and eToM in 45 young female patients with AN and 53 control participants. Next, the mediation model was assessed using a subsample of 33 AN patients and 34 controls, in which interpersonal mistrust was additionally assessed.ResultsThe CAMHeb correlated with the measures of mentalizing ability and eToM. The CAMHeb, along with the measure of general mentalizing, significantly differentiated between the AN and control groups. The associations of general mentalizing and CAMHeb with eating disorder (ED) symptoms were mediated by interpersonal mistrust.ConclusionThe CAMHeb is a valid measure of deficient eToM in AN. In therapy, an increase in mentalizing ability and accurate eToM may enhance interpersonal trust, which may further contribute to attenuation of AN symptoms.
Development of ripple reduced solar photovoltaic regulators using boomerang sliding mode control strategy
Authors: MS Kamalesh , Nattuthurai Senthilnathan , Chokkalingam Bharatiraja , Muthusamy Sabarimuthu , Cherukupalli Kumar 
Published: June 2021

SummaryDC–DC boost converters are extensively used in wide range of solar photovoltaic (PV) applications. A common problem in PV regulator is the presence of ripples in output voltage and output current, due to the oscillations in PV power, inaccurate switching, and inadmissible inductor peak currents. In general, conventional boost converters are widely used in PV regulator; however, conventional PWM‐controlled boost converters are upgraded to sliding mode controller (SMC)‐based PWM controllers, which has been elaborated in the literature. However, SMC‐based boost converter experiences the following problems: (i) presence of ripples in the output current and (ii) dynamic instability during sudden change in load current. This paper addresses the aforementioned problems and proposes a boomerang trajectory‐based SMC (BT‐SMC) control strategy for ripple mitigation in conventional DC–DC boost converters specifically used in PV regulator. BT‐SMC tracker tracks the reference wave shape and controls the duty cycle, with respect to the switching frequency to have a ripple mitigated output. This self‐adapting system provides an adequate reduction in ripples and rapid convergence of error nearest to zero. A detailed analysis on switching frequency transition, load variation, trajectory control, and its stability existence is conducted, and the proposed system is implemented using dSPACE‐MicroLabBox‐DS1202.
Designing a reliable and energy‐efficient cross‐layer protocol for wireless sensor networks
Authors: Alabady Salah Abdulghani , Alhajji Sukaina Shukur 
Published: June 2021

SummaryDue to the energy scarcity that the wireless sensor networks currently face, many energy‐efficient protocols have been developed and proposed in different layers, especially in the data link and network layers, as a large amount of energy consumed by the transceiver, idle‐listening, collision, selecting the correct nodes to act as routers, long‐distance transmission, etc., which are the responsibility of data link and network layers. Since these protocols address the reasons for energy loss in one layer and neglect the treatment of energy loss in other layers, as each layer of the TCP/IP module has its own features and has no control over the other layers. Therefore, there was a need for a cross‐layer design. In this paper, an energy‐efficient cross‐layer between MAC layer and network layer has been proposed using slotted ALOHA based p‐persistent CSMA MAC protocol and Enhance Energy Conservation based on Residual Energy and Distance (EECRED) in order to reduce energy consumption and increase the network lifetime. The performance of the proposed cross‐layer protocol is evaluated by simulating the protocol using the MATLAB simulation. The simulation results are compared with the Fuzzy and Ant Colony Optimization (ACO) based MAC/Routing cross‐layer protocol (FAMACRO), FAMACRO for wireless sensor networks (FAMACROW), fuzzy cross‐layer LEACH, routing‐MAC, and Energy‐efficient Cross‐layer‐sensing Clustering Method (ECCM) protocols to ensure the efficiency of the proposed cross‐layer. The simulation results show that the proposed cross‐layer protocol is very energy efficient, provides stable networks, consumes little energy, and significantly increases the life of the network compared to the single‐layer protocols where the improvement rate was 45%, 53%, 37%, 91%, and 28.72% compared to FAMACRO, FAMAROW, fuzzy cross‐layer LEACH, routing‐MAC, and ECCM protocols respectively in terms of the number of alive nodes or residual energy.
Canadian Indigenous Cognitive Assessment (CICA): Inter‐rater reliability and criterion validity in Anishinaabe communities on Manitoulin Island, Canada
Authors: Walker Jennifer D. , O'Connell Megan E. , Pitawanakwat Karen , Blind Melissa , Warry Wayne , Lemieux Andrine , Patterson Christopher , Allaby Cheryl , Valvasori Meghan , Zhao Yantao , Jacklin Kristen 
Published: June 2021

AbstractIntroductionDespite increasing dementia rates, few culturally informed cognitive assessment tools exist for Indigenous populations. The Canadian Indigenous Cognitive Assessment (CICA) was adapted with First Nations on Manitoulin Island, Canada, and provides a brief, multi‐domain cognitive assessment in English and Anishinaabemowin.MethodsUsing community‐based participatory research (CBPR) methods, we assessed the CICA for inter‐rater and test–retest reliability in 15 individuals. We subsequently evaluated validity and established meaningful CICA cut‐off scores in 55 individuals assessed by a geriatrician.ResultsThe CICA demonstrated strong reliability (intra‐class coefficient = 0.95 [0.85,0.98]). The area under the curve (AUC) was 0.98 (0.94, 1.00), and the ideal cut‐point to identify likely cases of dementia was a score of less than or equal to 34 with sensitivity of 100% and specificity of 85%.DiscussionWhen used with older First Nations men and women living in First Nations communities, the CICA offers a culturally safe, reliable, and valid assessment to support dementia case‐finding.
Potential use of serum‐derived bovine immunoglobulin/protein isolate for the management of COVID‐19
Authors: Utay Netanya S. , Asmuth David M. , Gharakhanian Shahin , Contreras Moises , Warner Christopher D. , Detzel Christopher J. 
Published: June 2021

AbstractCOVID‐19 manifests as a mild disease in most people but can progress to severe disease in nearly 20% of individuals. Disease progression is likely driven by a cytokine storm, either directly stimulated by SARS‐CoV‐2 or by increased systemic inflammation in which the gut might play an integral role. SARS‐CoV‐2 replication in the gut may cause increased intestinal permeability, alterations to the fecal microbiome, and increased inflammatory cytokines. Each effect may lead to increased systemic inflammation and the transport of cytokines and inflammatory antigens from the gut to the lung. Few interventions are being studied to treat people with mild disease and prevent the cytokine storm. Serumderived bovine immunoglobulin/protein isolate (SBI) may prevent progression by (1) binding and neutralizing inflammatory antigens, (2) decreasing gut permeability, (3) interfering with ACE2 binding by viral proteins, and (4) improving the fecal microbiome. SBI is therefore a promising intervention to prevent disease progression in COVID‐19 patients.
New image‐processing technology for endoscopic ultrasound‐guided fine‐needle aspiration biopsy specimen evaluation in patients with pancreatic cancer
Authors: Okuwaki Kosuke , Imaizumi Hiroshi , Kida Mitsuhiro , Masutani Hironori , Watanabe Masafumi , Adachi Kai , Tadehara Masayoshi , Tamaki Akihiro , Iwai Tomohisa , Yamauchi Hiroshi , Hasegawa Rikiya , Kaneko Toru , Kurosu Takahiro , Koizumi Wasaburo 
Published: June 2021

AbstractObjectivesWe evaluated the usefulness of a newly developed system with which the total amount of whitish cores in endoscopic ultrasound‐guided fine‐needle aspiration biopsy (EUS‐FNAB) samples is automatically calculated (automated multiband imaging system [AMUS]).MethodsFrom 30 prospectively enrolled patients suspected of having pancreatic cancer, four EUS‐FNAB specimens per patient were obtained. Following AMUS calculations, two specimens were prepared after stereomicroscopy‐guided manual division into whitish and reddish sections (isolation group), and the other two were prepared without such division (no‐isolation group). The relation of the AMUS results pertaining to the length of the manually measured whitish cores (stereo‐microscopically visible white core [SVWC]) and the sample suitability for pathologic evaluation were analyzed.ResultsHistological diagnostic accuracy was 90%; median SVWC length, 14 mm; and median area of whitish core calculated using the AMUS, 13 mm2. The SVWC length correlated with whitish core amount (ρ = 0.83, p < 0.01) and adequacy score (ρ = 0.50, p < 0.01). The whitish core amount correlated with the adequacy score (ρ = 0.40, p < 0.01). The area under the receiver‐operating characteristic curve calculated for whitish core amount with respect to the histological diagnosis was 0.84 (p < 0.01; cutoff ≥ 8 mm2, sensitivity 92.5%). Subgroup analysis (isolation vs. no‐isolation group) revealed no significant between‐group differences in the median histological adequacy (p = 0.27) or tumor cell content ratio (p = 0.28). The median scores for degree of blood contamination were significantly lower in the isolation group than in the no‐isolation group (p < 0.01).ConclusionAMUS is a simple on‐site verification procedure for determining the appropriate sampling tissue quantity for high diagnostic accuracy.