bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID‐19 convalescent plasma cohort study: Evaluation of the association between both donor and recipient neutralizing antibody titers and patient outcomes
Authors: Yokoyama Ana Paula H. , Wendel Silvano , Bonet‐Bub Carolina , Fachini Roberta M. , Dametto Ana Paula F. , Blumm Fernando , Dutra Valeria F. , Candelaria Gabriela T. P. , Sakashita Araci M. , Machado Rafael Rahal Guaragna , Fontão‐Wendel Rita , Hamerschlak Nelson , Achkar Ruth , Assunção Murillo Santucci Cesar , Scuracchio Patrícia , Nudelman Victor , Pastore Laerte , Pinho João R. R. , Ben Mirian Dal , Filho Roberto Kalil , Marra Alexandre R. , Amano Mariane T. , Kallás Esper G. , Helito Alfredo Salim , de Carvalho Carlos Roberto Ribeiro , Araujo Danielle Bastos , Durigon Edison Luiz , Camargo Anamaria A. , Rizzo Luiz V. , Reis Luiz F. L. , Kutner Jose M. 
Published: June 2021

AbstractBackgroundCurrent evidence regarding COVID‐19 convalescent plasma (CCP) transfusion practices is limited and heterogeneous. We aimed to determine the impact of the use of CCP transfusion in patients with previous circulating neutralizing antibodies (nAbs) in COVID‐19.MethodsProspective cohort including 102 patients with COVID‐19 transfused with ABO compatible CCP on days 0–2 after enrollment. Clinical status of patients was assessed using the adapted World Health Organization (WHO) ordinal scale on days 0, 5, and 14. The nAbs titration was performed using the cytopathic effect‐based virus neutralization test with SARS‐CoV‐2 (GenBank MT126808.1). The primary outcome was clinical improvement on day 14, defined as a reduction of at least two points on the adapted WHO ordinal scale. Secondary outcomes were the number of intensive care unit (ICU)‐free days and the number of invasive mechanical ventilation‐free days.ResultsBoth nAbs of CCP units transfused (p < 0.001) and nAbs of patients before CCP transfusions (p = 0.028) were associated with clinical improvements by day 14. No significant associations between nAbs of patients or CCP units transfused were observed in the number of ICU or mechanical ventilation‐free days. Administration of CCP units after 10 days of symptom onset resulted in a decrease in ICU‐free days (p < 0.001) and mechanical ventilation‐free days (p < 0.001).ConclusionTransfusion of high titer nAbs CCP units may be a determinant in clinical strategies against COVID‐19. We consider these data as useful parameters to guide future CCP transfusion practices.
Post‐operative complications following apocrine gland anal sac adenocarcinoma resection in dogs
Authors: Sterman Allyson , Butler J. Ryan , Chambers Aidan , Dickson Rachel , Dornbusch Josephine , Mickelson Megan , Selmic Laura , Scharf Valerie , Schlag Ariel , Skinner Owen , Vinayak Arathi , Janssens Brandan Wustefeld 
Published: June 2021

AbstractDescribe the complications associated with surgical resection of primary apocrine gland anal sac adenocarcinoma (AGASACA) tumours study design multi‐institutional retrospective cross‐sectional cohort study Animals Client owned dogs with spontaneous disease using the Clavien‐Dindo classification system, post‐operative events were assigned and described. Logistic regression analysis was used to analyse for risk factors for a significant association with complications. One hundred sixty‐one dogs were included in the analysis. The post‐operative sequelae, complication, and failure to cure rates specific to the anal sac site was 14%, 17% and 1%, respectively. The majority (68%) of complications were grade II or higher, therefore requiring some form of intervention. Intra‐operative complications were identified in 11 cases (7%) with anorectal wall perforation being most common. An intra‐operative complication was significantly associated with post‐operative complications (p < 0.001; OR 7.4) while anorectal wall perforation was the only significant risk factor on regression analysis (p < 0.001; OR 19). Surgical site infection was identified in 20 of 161 (12%) of cases. Local recurrence (LR) occurred in 18% of cases at a median of 374 days (95% CI: 318–430). The only risk factor significantly associated with LR was the presence of vascular or lymphatic invasion (p = 0.008; OR 3). Post‐operative complications were relatively infrequent but the risk was significantly increased when there was an intraoperative complication during resection of a primary AGASACA tumour. This study provides information for the clinician regarding risk factors for post‐operative complications.
Axonal GABAA stabilizes excitability in unmyelinated sensory axons secondary to NKCC1 activity
Authors: Bonalume Veronica , Caffino Lucia , Castelnovo Luca F. , Faroni Alessandro , Liu Sheng , Hu Jing , Milanese Marco , Bonanno Giambattista , Sohns Kyra , Hoffmann Tal , De Col Roberto , Schmelz Martin , Fumagalli Fabio , Magnaghi Valerio , Carr Richard 
Published: June 2021

Key points
GABA depolarized sural nerve axons and increased the electrical excitability of C‐fibres via GABAA receptor.
Axonal excitability responses to GABA increased monotonically with the rate of action potential firing.
Action potential activity in unmyelinated C‐fibres is coupled to Na‐K‐Cl cotransporter type 1 (NKCC1) loading of axonal chloride.
Activation of axonal GABAA receptor stabilized C‐fibre excitability during prolonged low frequency (2.5 Hz) firing.
NKCC1 maintains intra‐axonal chloride to provide feed‐forward stabilization of C‐fibre excitability and thus support sustained firing.
AbstractGABAA receptor (GABAAR)‐mediated depolarization of dorsal root ganglia (DRG) axonal projections in the spinal dorsal horn is implicated in pre‐synaptic inhibition. Inhibition, in this case, is predicated on an elevated intra‐axonal chloride concentration and a depolarizing GABA response. In the present study, we report that the peripheral axons of DRG neurons are also depolarized by GABA and this results in an increase in the electrical excitability of unmyelinated C‐fibre axons. GABAAR agonists increased axonal excitability, whereas GABA excitability responses were blocked by GABAAR antagonists and were absent in mice lacking the GABAAR β3 subunit selectively in DRG neurons (AdvillinCre or snsCre). Under control conditions, excitability responses to GABA became larger at higher rates of electrical stimulation (0.5–2.5 Hz). However, during Na‐K‐Cl cotransporter type 1 (NKCC1) blockade, the electrical stimulation rate did not affect GABA response size, suggesting that NKCC1 regulation of axonal chloride is coupled to action potential firing. To examine this, activity‐dependent conduction velocity slowing (activity‐dependent slowing; ADS) was used to quantify C‐fibre excitability loss during a 2.5 Hz challenge. ADS was reduced by GABAAR agonists and exacerbated by either GABAAR antagonists, β3 deletion or NKCC1 blockade. This illustrates that activation of GABAAR stabilizes C‐fibre excitability during sustained firing. We posit that NKCC1 acts in a feed‐forward manner to maintain an elevated intra‐axonal chloride in C‐fibres during ongoing firing. The resulting chloride gradient can be utilized by GABAAR to stabilize axonal excitability. The data imply that therapeutic strategies targeting axonal chloride regulation at peripheral loci of pain and itch may curtail aberrant firing in C‐fibres.
World Championship and Olympic Games Experience Influences Future Medal Performance in Track-and-Field Athletes
Authors: Fulton Timothy J. , Baranauskas Marissa N. , Chapman Robert F. 
Published: June 2021

Some track-and-field national governing bodies send athletes to World Championship and Olympic Games (WC/OG) to gain experience that may positively impact future success, even though athletes may not be expected to place high or medal. However, it is unclear if this strategy is advantageous for future medal attainment. Purpose: To determine if participation and/or advancement at a track-and-field athlete’s first WC/OG influences the odds of future medaling. Methods: Performances of US track-and-field athletes who made their first WC/OG team during 2000–2013 were tracked through 2016 to stratify athletes into categories. Athletes who medaled on their first team or never made a subsequent team (ie, no experience) were compared with athletes who did not medal on their first team but made subsequent teams (ie, experience). The experience group was further divided into athletes who advanced or did not advance out of the initial round at their first competition for a secondary analysis. Odds ratios (ORs) were calculated using logistic regression to measure the association between experience level and medaling. Results: A significant OR was obtained for advanced versus did not advance (OR = 2.29, 95% confidence interval, 1.07–4.89, P = .03), but not for experience versus no experience (OR = 1.04, 95% confidence interval, 0.60–1.78, P = .91) group. Conclusions: Advancing out of the initial round of competition during an athlete’s first WC/OG competition is associated with increased odds of future medaling. National governing bodies should consider this “experience threshold” during team selection processes.
Single $$\pi ^0$$ production off neutrons bound in deuteron with linearly polarized photons
Authors: Mullen C. , Gardner S. , Glazier D. I. , Kay S. J. D. , Livingston K. , Strakovsky I. I. , Workman R. L. , Abt S. , Achenbach P. , Afzal F. , Ahmed Z. , Akondi C. S. , Annand J. R. M. , Bashkanov M. , Beck R. , Biroth M. , Borisov N. S. , Braghieri A. , Briscoe W. J. , Cividini F. , Collicott C. , Costanza S. , Denig A. , Dieterle M. , Downie E. J. , Drexler P. , Fegan S. , Ferretti-Bondy M. I. , Ghosal D. , Gorodnov I. , Gradl W. , Günther M. , Gurevic G. , Heijkenskjöld L. , Hornidge D. , Huber G. M. , Jermann N. , Kaeser A. , Korolija M. , Kashevarov V. L. , Krusche B. , Kulikov V. V. , Lazarev A. , Lutterer S. , MacGregor I. J. D. , Manley D. M. , Martel P. P. , Martemianov M. A. , Meier C. , Miskimen R. , Mocanu M. , Mornacchi E. , Neganov A. , Oberle M. , Ostrick M. , Otte P. , Paudyal D. , Pedroni P. , Powell A. , Prakhov S. N. , Reicherz G. , Ron G. , Rostomyan T. , Sfienti C. , Sokhoyan V. , Spieker K. , Steffen O. , Strub Th. , Supek I. , Thiel A. , Thiel M. , Thomas A. , Unverzagt M. , Usov Yu. A. , Wagner S. , Walford N. K. , Watts D. P. , Werthmüller D. , Wettig J. , Witthauer L. , Wolfes M. , Zachariou N. ,   (A2 Collaboration at MAMI)
Published: June 2021

AbstractThe quasifree$$\overrightarrow{\gamma } d\rightarrow \pi ^0n(p)$$γ→d→π0n(p)photon beam asymmetry,$$\varSigma $$Σ, has been measured at photon energies,$$E_\gamma $$Eγ, from 390 to 610 MeV, corresponding to center of mass energy from 1.271 to 1.424 GeV, for the first time. The data were collected in the A2 hall of the MAMI electron beam facility with the Crystal Ball and TAPS calorimeters covering pion center-of-mass angles from 49$$^\circ $$∘to 148$$^\circ $$∘. In this kinematic region, polarization observables are sensitive to contributions from the$$\varDelta (1232)$$Δ(1232)andN(1440) resonances. The extracted values of$$\varSigma $$Σhave been compared to predictions based on partial-wave analyses (PWAs) of the existing pion photoproduction database. Our comparison includes the SAID, MAID and Bonn–Gatchina analyses; while a revised SAID fit, including the new$$\varSigma $$Σmeasurements, has also been performed. In addition, isospin symmetry is examined as a way to predict$$\pi ^0n$$π0nphotoproduction observables, based on fits to published data in the channels$$\pi ^0p$$π0p,$$\pi ^+n$$π+nand$$\pi ^-p$$π-p.
HyperNOMAD
Authors: Lakhmiri Dounia , Digabel Sébastien Le , Tribes Christophe 
Published: June 2021

The performance of deep neural networks is highly sensitive to the choice of the hyperparameters that define the structure of the network and the learning process. When facing a new application, tuning a deep neural network is a tedious and time-consuming process that is often described as a “dark art.” This explains the necessity of automating the calibration of these hyperparameters. Derivative-free optimization is a field that develops methods designed to optimize time-consuming functions without relying on derivatives. This work introduces the HyperNOMAD package, an extension of the NOMAD software that applies the MADS algorithm [7] to simultaneously tune the hyperparameters responsible for both the architecture and the learning process of a deep neural network (DNN). This generic approach allows for an important flexibility in the exploration of the search space by taking advantage of categorical variables. HyperNOMAD is tested on the MNIST, Fashion-MNIST, and CIFAR-10 datasets and achieves results comparable to the current state of the art.
A new distribution record of the Horn Coral Caryophyllia grandis Gardiner & Waugh, 1938 (Anthozoa: Scleractinia) from the Karnataka Coast, India
Authors: Yogesh Kumar J. S. , Raghunathan C. 
Published: June 2021

Surveys were conducted under the project entitled “Resource exploration and Inventorisation of Deep Sea ecosystem & Marine ecosystem Dynamics: Sagar Sampada Cruise” by on-board FORV Sagar Sampada Cruise No. 374 from 2 April to 15 April 2018 from Okha to Cochin along the west coast of India. The species Caryophyllia (Caryophyllia) grandis is recorded from a depth of 580m off Karwar, Karnataka and is reported herein as a new distribution record to the Karnataka coast, India.
Population assessment and habitat distribution modelling of the threatened medicinal plant Picrorhiza kurroa Royle ex Benth. in the Kumaun Himalaya, India
Authors: Chandra Naveen , Singh Gajendra , Lingwal Shashank , Bisht M.P.S. , Tiwari Lalit Mohan 
Published: June 2021

Kumaun Himalaya is a home to various threatened medicinal and aromatic plants. Picrorhiza kurroa is a threatened medicinal plant useful in curing many diseases in Indian Himalayan region. Due to overharvesting from the wild its population is decreasing at an alarming rate. The present study attempted to assess its availability and predict highly suitable areas for in situ conservation in the alpine region of Kumaun. Availability of P. kurroa across various meadows was evaluated through rapid mapping exercise. MaxEnt model was used to predict the geographical distribution of the species using various environmental and physiographic parameters, and 29 primary distribution points. The results reveal that potential habitat of P. kurroa is located near forest fringes. Of the 3,828km2 area (vegetated) of the alpine region of Kumaun, about 202km2 is recorded highly suitable, 489km2 less suitable and the rest not suitable for the species. It is also revealed that Napalchu nala, Panchachuli base, Chhipla Kedar, Rongkong, Ralam, Milam, Dwali, and Pindari areas are highly suitable areas for distribution of P. kurroa.
The tribe Cnodalonini (Coleoptera: Tenebrionidae: Stenochiinae) from Maharashtra with two new records
Authors: Hegde V.D. , Vasanthakumar D. 
Published: June 2021

The tenebrionidae collections of Western Regional Centre, Zoological Survey of India Pune were identified. The species identified as Promethis brevicornis (Westwood, 1842) and Gebienocamaria girardi Masumoto, 1993 and collected from Sangli District and Koyna Wildlife Sanctuary, Satara, respectively constitute a new record for Maharashtra State.
Birds of Surat-Dangs: a consolidated checklist of 75 years (1944–2020) with special emphasis on noteworthy bird records and bird hotspots from northern Western Ghats of Gujarat, India
Authors: Jambu Nikunj , Patel Kaushal G. 
Published: June 2021

Surat-Dangs, historically known as a Bhil State, is the northernmost tip of Western Ghats in the state of Gujarat. Despite being a part of an endemic bird area and global biodiversity hotspot, avifaunal diversity has been less documented in the landscape. Two protected areas, Purna Wildlife Sanctuary and Vansda National Park, are designated in the landscape. A handful of studies on birds have been conducted after Dr. Salim Ali’s collection in 1944–48. We surveyed the landscape (both protected and non-protected areas) in 2012–13 and 2015–2018 for documentation of the avifaunal diversity. We present a consolidated checklist of birds from our surveys as primary data and all published literature and eBird checklists as secondary data. We have reported a total of 297 bird species belonging to 70 families and 21 orders including the first record of Nilgiri Wood-Pigeon Columba elphinstonii for the State as well as Purna Wildlife Sanctuary. Here, we have re-reported various species, which was suspected to be locally extinct from the protected area or landscape among other noteworthy bird records. We have identified bird-rich localities outside the protected areas based on the survey done by Salim Ali (1944–48) that can be used for future surveys. We also propose the landscape to be declared as an Important Bird Area (IBA) as per Global IBA criteria (A1, A2, & A3), which will pave the milestone for future conservation endeavors in the landscape.
Identification of a unique barb from the dorsal body contour feathers of the Indian Pitta Pitta brachyura (Aves: Passeriformes: Pittidae)
Authors: Dey Prateek , Ray Swapna Devi , Sharma Sanjeev Kumaar , Pramod Padmanabhan , Singh Ram Pratap 
Published: June 2021

Earlier research on feather morphology emphasized comprehensively on the body contour feather than various other types of feathers. Therefore, we conducted a systematic study on all feather types of the Indian Pitta Pitta brachyura, a passerine bird native to the Indian subcontinent. Feather barbs from wing contour, tail contour, body contour, semiplume, down, powder down, and bristle feathers were retrieved from the bird and observed under a light microscope. Primary flight feathers from the right and left wing were longest (85.17 mm and 87.32 mm, respectively), whereas bristle feathers were the shortest (5.31 mm). The mean barb length was observed to be the highest (11.37±0.47 mm) in the wing feather followed by body contour (8.31±0.39 mm), semiplume (8.27±0.22 mm), tail feather (7.85±0.50 mm), down (6.45±0.21 mm), powder down (6.04±0.23 mm), and bristle (2.70±0.07 mm). Pearson correlation was found positive for barb length and feather length of down feathers (r= 0.996, p ≤0.05). We observed a novel type of barb the first time from dorsal body contour feather having plumulaceous barbules at the base followed by pennaceous barbules. This unique barbule arrangement is termed ‘sub-plumulaceous’ as it is distinct and analogous to known ‘sub-pennaceous’ type arrangement found absent in passerines.
New records of Agriocnemis keralensis Peters, 1981 and Gynacantha khasiaca MacLachlan, 1896 (Insecta: Odonata) from Maharashtra, India
Authors: Koli Yogesh , Dalvi Akshay , Sawant Dattaprasad 
Published: June 2021

Agriocnemis keralensis Peters, 1981 is reported for the first time from Maharashtra, India. Previously it was known from Kerala and Goa states. In this paper we report A. keralensis from Thakurwadi and Bambuli wetlands and Chipi Plateau, Sindhudurg District. Also, the new record of Gynacantha khasiaca MacLachlan, 1896 is confirmed on the basis of specimens collected from Sindhudurg District. Hence, we report the range extension of both A. keralensis and G. khasiaca in northern Western Ghats. Apart from this, a combined checklist of Odonata fauna of Thakurwadi (51 species), Bambuli wetlands (44 species), and Chipi Plateau (51 species) is provided.
Long‐Term Blood Pressure Variability and Risk of Cognitive Decline and Dementia Among Older Adults
Authors: Ernst Michael E. , Ryan Joanne , Chowdhury Enayet K. , Margolis Karen L. , Beilin Lawrence J. , Reid Christopher M. , Nelson Mark R. , Woods Robyn L. , Shah Raj C. , Orchard Suzanne G. , Wolfe Rory , Storey Elsdon , Tonkin Andrew M. , Brodtmann Amy , McNeil John J. , Murray Anne M. 
Published: June 2021

Background
Blood pressure variability (BPV) in midlife increases risk of late‐life dementia, but the impact of BPV on the cognition of adults who have already reached older ages free of major cognitive deficits is unknown. We examined the risk of incident dementia and cognitive decline associated with long‐term, visit‐to‐visit BPV in a post hoc analysis of the ASPREE (Aspirin in Reducing Events in the Elderly) trial.

Methods and Results

ASPREE participants (N=19 114) were free of dementia and significant cognitive impairment at enrollment. Measurement of BP and administration of a standardized cognitive battery evaluating global cognition, delayed episodic memory, verbal fluency, and processing speed and attention occurred at baseline and follow‐up visits. Time‐to‐event analysis using Cox proportional hazards regression models were used to calculate hazard ratios (HR) and corresponding 95% CI for incident dementia and cognitive decline, according to tertile of SD of systolic BPV. Individuals in the highest BPV tertile compared with the lowest had an increased risk of incident dementia and cognitive decline, independent of average BP and use of antihypertensive drugs. There was evidence that sex modified the association with incident dementia (interaction
P
=0.02), with increased risk in men (HR, 1.68; 95% CI, 1.19–2.39) but not women (HR, 1.01; 95% CI, 0.72–1.42). For cognitive decline, similar increased risks were observed for men and women (interaction
P
=0.15; men: HR, 1.36; 95% CI, 1.16–1.59; women: HR, 1.14; 95% CI, 0.98–1.32).

Conclusions
High BPV in older adults without major cognitive impairment, particularly men, is associated with increased risks of dementia and cognitive decline.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01038583;
isrctn.com
. Identifier: ISRCTN83772183.
Discordance Between Severity of Heart Failure as Determined by Patient Report Versus Cardiopulmonary Exercise Testing
Authors: Michelis Katherine C. , Grodin Justin L. , Zhong Lin , Pandey Ambarish , Toto Kathleen , Ayers Colby R. , Thibodeau Jennifer T. , Drazner Mark H. 
Published: June 2021

Background
Patient‐reported outcomes may be discordant to severity of illness as assessed by objective parameters. The frequency of this discordance and its influence on clinical outcomes in patients with heart failure is unknown.

Methods and Results

In HF‐ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training), participants (N=2062) had baseline assessment of health‐related quality of life via the Kansas City Cardiomyopathy Clinical Summary score (KCCQ‐CS) and objective severity by cardiopulmonary stress testing (minute ventilation [V
E
]/carbon dioxide production [VCO
2
] slope). We defined 4 groups by median values: 2 concordant (lower severity: high KCCQ‐CS and low V
E
/VCO
2
slope; higher severity: low KCCQ‐CS and high V
E
/VCO
2
slope) and 2 discordant (symptom minimizer: high KCCQ‐CS and high V
E
/VCO
2
slope; symptom magnifier: low KCCQ‐CS and low V
E
/VCO
2
slope). The association of group assignment with mortality was assessed in adjusted Cox models. Symptom magnification (23%) and symptom minimization (23%) were common. Despite comparable KCCQ‐CS scores, the risk of all‐cause mortality in symptom minimizers versus concordant–lower severity participants was increased significantly (hazard ratio [HR], 1.79; 95% CI, 1.27–2.50;
P
<0.001). Furthermore, despite symptom magnifiers having a KCCQ‐CS score 28 points lower (poorer QOL) than symptom minimizers, their risk of mortality was not increased (HR, 0.79; 95% CI, 0.57–1.1;
P
=0.18, respectively).

Conclusions
Severity of illness by patient report versus cardiopulmonary exercise testing was frequently discordant. Mortality tracked more closely with the objective data, highlighting the importance of relying not only on patient report, but also objective data when risk stratifying patients with heart failure.