bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive validity of attention-deficit/hyperactivity disorder from ages 3 to 5 Years
Authors: Overgaard Kristin Romvig , Oerbeck Beate , Friis Svein , Pripp Are Hugo , Aase Heidi , Zeiner Pål 
Published: March 2021

AbstractWe investigated to what extent parent-rated attention-deficit/hyperactivity disorder (ADHD) and impairment at age 3 years predicted elevated ADHD symptoms at age 5 years, and whether teacher-rated ADHD symptoms improved these predictions. This study is part of the longitudinal, population-based Norwegian Mother, Father and Child Cohort Study. Parents of 3-year-old children (n = 1195) were interviewed about ADHD and impairment, and teachers rated child ADHD symptoms by the Strengths and Difficulties Questionnaire or the Early Childhood Inventory-4. At 5 years of age, the children (n = 957) were classified as ADHD-positive or -negative using Conners’ Parent Rating Scale. Relying solely on parent-rated ADHD or impairment at age 3 years did moderately well in identifying children with persistent elevation of ADHD symptoms, but gave many false positives (positive predictive values (PPVs): .40–.57). A small group of children (n = 20, 13 boys) scored above cut-off on both parent-rated ADHD and impairment, and teacher-rated ADHD symptoms, although adding teacher-rated ADHD symptoms slightly weakened the predictive power for girls. For this small group, PPVs were .76 for boys and .64 for girls. Limiting follow-up to these few children will miss many children at risk for ADHD. Therefore, we recommend close monitoring also of children with parent-reported ADHD symptoms and/or impairment to avoid delay in providing interventions. Clinicians should also be aware that teachers may miss ADHD symptoms in preschool girls.
The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation in the zebrafish trunk
Authors: Mauri Cristina , van Impel Andreas , Mackay Eirinn William , Schulte-Merker Stefan 
Published: March 2021

AbstractVegfc/Vegfr3 signaling is critical for lymphangiogenesis, the sprouting of lymphatic vessels. In zebrafish, cells sprouting from the posterior cardinal vein can either form lymphatic precursor cells or contribute to intersegmental vein formation. Both, the Vegfc-dependent differential induction of Prox1a in sprouting cells as well as a Notch-mediated pre-pattern within intersegmental vessels have been associated with the regulation of secondary sprout behavior. However, how exactly a differential lymphatic versus venous sprout cell behavior is achieved is not fully understood. Here, we characterize a zebrafish mutant in the adaptor protein Grb2b, and demonstrate through genetic interaction studies that Grb2b acts within the Vegfr3 pathway. Mutant embryos exhibit phenotypes that are consistent with reduced Vegfr3 signaling outputs prior to the sprouting of endothelial cells from the vein. During secondary sprouting stages, loss ofgrb2bleads to defective cell behaviors resulting in a loss of parachordal lymphangioblasts, while only partially affecting the number of intersegmental veins. A second GRB2 zebrafish ortholog,grb2a, contributes to the development of lymphatic structures in the meninges and in the head, but not in the trunk. Our results illustrate an essential role of Grb2b in vivo for cell migration to the horizontal myoseptum and for the correct formation of the lymphatic vasculature, while being less critically required in intersegmental vein formation. Thus, there appear to be higher requirements for Grb2b and therefore Vegfr3 downstream signaling levels in lymphatic versus vein precursor-generating sprouts.
Review of Cognitive Characteristics of Autism Spectrum Disorder Using Performance on Six Subtests on Four Versions of the Wechsler Intelligence Scale for Children
Authors: Takayanagi Mizuho , Kawasaki Yoko , Shinomiya Mieko , Hiroshi Hoshino , Okada Satoshi , Ino Tamiko , Sakai Kazuko , Murakami Kimiko , Ishida Rie , Mizuno Kaoru , Niwa Shin-Ichi 
Published: March 2021

AbstractThis study was a systematic review of research using the Wechsler Intelligence Scale for Children (WISC) with Autism Spectrum Disorder (ASD) to examine cognitive characteristics of children with ASD beyond the impact of revisions based on WISC and diagnostic criteria changes. The classic “islets of ability” was found in individuals with full-scale IQs < 100. The “right-descending profiles” were observed among high IQ score individuals. High levels on the Block Design and low Coding levels were consistently found regardless of the variation in intellectual functioning or diagnosis. This review identified patterns of cognitive characteristics in ASD individuals using empirical data that researchers may have previously been aware of, based on their experiences, owing to the increased prevalence of ASD.
Cell-based non-invasive prenatal testing for monogenic disorders: confirmation of unaffected fetuses following preimplantation genetic testing
Authors: Toft Christian Liebst Frisk , Ingerslev Hans Jakob , Kesmodel Ulrik Schiøler , Hatt Lotte , Singh Ripudaman , Ravn Katarina , Nicolaisen Bolette Hestbek , Christensen Inga Baasch , Kølvraa Mathias , Jeppesen Line Dahl , Schelde Palle , Vogel Ida , Uldbjerg Niels , Farlie Richard , Sommer Steffen , Østergård Marianne Louise Vang , Jensen Ann Nygaard , Mogensen Helle , Kjartansdóttir Kristín Rós , Degn Birte , Okkels Henrik , Ernst Anja , Pedersen Inge Søkilde 
Published: March 2021

Abstract
Purpose
Proof of concept of the use of cell-based non-invasive prenatal testing (cbNIPT) as an alternative to chorionic villus sampling (CVS) following preimplantation genetic testing for monogenic disorders (PGT-M).

Method
PGT-M was performed by combined testing of short tandem repeat (STR) markers and direct mutation detection, followed by transfer of an unaffected embryo. Patients who opted for follow-up of PGT-M by CVS had blood sampled, from which potential fetal extravillous throphoblast cells were isolated. The cell origin and mutational status were determined by combined testing of STR markers and direct mutation detection using the same setup as during PGT. The cbNIPT results with respect to the mutational status were compared to those of genetic testing of the CVS.

Results
Eight patients had blood collected between gestational weeks 10 and 13, from which 33 potential fetal cell samples were isolated. Twenty-seven out of 33 isolated cell samples were successfully tested (82%), of which 24 were of fetal origin (89%). This corresponds to a median of 2.5 successfully tested fetal cell samples per case (range 1–6). All fetal cell samples had a genetic profile identical to that of the transferred embryo confirming a pregnancy with an unaffected fetus, in accordance with the CVS results.

Conclusion
These findings show that although measures are needed to enhance the test success rate and the number of cells identified, cbNIPT is a promising alternative to CVS.

Trial registration number
N-20180001
The effects of a special sequential mixed-mode design, and reminders, on panellists’ participation in a probability-based panel study
Authors: Becker Rolf 
Published: March 2021

AbstractThe sequential mixed-mode strategy has become standard practice in the survey management of longitudinal studies, in order to achieve consistently high response rates. To realise this aim in a cost-efficient way, a first mode is often an online questionnaire, towards which the target persons are pushed, and a second mode is then a telephone interview, offered to those who do not respond to the initial mode. However, the rationale for using the sequential mixed-mode plus “push-to-web” strategy to reduce the burden of choosing between survey modes, in order to maximise survey participation, could be undermined if there is an overlapping field period during which the target persons could choose between two or more offered modes. The use of reminders might be useful in solving this problem of competing risks. In the context of a multiple-panel study, this question was investigated by utilising longitudinal paradata from the fieldwork, as well as procedures of event history analysis that are adequate for the analysis of processes with competing risks. First, for a web survey as the initial mode and computer-assisted telephone interview (CATI) as the subsequent mode, it was found that the idea of a sequential mixed-mode plus “push-to-web” strategy does work even in the case of competing risks in the choice of a survey mode. Second, it was confirmed that reminders are a useful instrument for stimulating panellists to choose the running survey mode. Third, and finally, it was found that this feature of survey management is effective in countering panellists’ procrastination in regard to responding to a survey.
Advances in MXene Films: Synthesis, Assembly, and Applications
Authors: Li Xiaohua , Ran Feitian , Yang Fan , Long Jun , Shao Lu 
Published: March 2021

AbstractA growing family of two-dimensional (2D) transition metal carbides or nitrides, known as MXenes, have received increasing attention because of their unique properties, such as metallic conductivity and good hydrophilicity. The studies on MXenes have been widely pursued, given the composition diversity of the parent MAX phases. This review focuses on MXene films, an important form of MXene-based materials for practical applications. We summarized the synthesis methods of MXenes, focusing on emerging synthesis strategies and reaction mechanisms. The advanced assembly technologies of MXene films, including vacuum-assisted filtration, spin-coating methods, and several other approaches, were then highlighted. Finally, recent progress in the applications of MXene films in electrochemical energy storage, membrane separation, electromagnetic shielding fields, and burgeoning areas, as well as the correlation between compositions, architecture, and performance, was discussed.
Indices of peripheral leukocytes predict longer overall survival in breast cancer patients on eribulin in Japan
Authors: Takahashi Masato , Inoue Kenichi , Mukai Hirofumi , Yamanaka Takashi , Egawa Chiyomi , Miyoshi Yasuo , Sakata Yukinori , Muramoto Kenzo , Ikezawa Hiroki , Matsuoka Toshiyuki , Tsurutani Junji 
Published: March 2021

Abstract
Background
It was reported that eribulin regulates the tumor microenvironment, including the immune system, by inducing vascular remodeling. Lymphocyte counts are a critical index of immune response in patients. The non-Asian, global EMBRACE study has suggested that baseline absolute lymphocyte count (ALC) may be a predictor of the survival benefit of eribulin in breast cancer patients. We examined whether the baseline ALC is a potential predictor of overall survival (OS) in Japanese patients with HER2-negative advanced breast cancer treated with eribulin.

Methods
This was a post hoc analysis of data from a post-marketing observational study of eribulin in Japan. The OS by baseline ALC was estimated using the Kaplan–Meier method, with the cut-off value of 1500/μL for ALC. The OS by baseline neutrophil-to-lymphocyte ratio (NLR), a general prognostic index in breast cancer patients, was also estimated, with the cut-off value of 3.

Results
The median OS was longer in patients with an ALC of ≥ 1500/μL than in those with an ALC of < 1500/μL (19.4 vs. 14.3 months; hazard ratio [HR]: 0.628; 95% confidence interval [CI]: 0.492, 0.801). Patients with an NLR of ≥ 3 showed shorter OS than those with an NLR of < 3 (13.2 vs. 18.8 months; HR: 1.552; 95% CI 1.254, 1.921), and NLR also separated OS in patients with an ALC of < 1500/μL.

Conclusions
Consistent with the findings of a previous study involving a non-Asian, Western population, our study suggested that baseline ALC may be a predictive factor for the survival benefit of eribulin in Japanese patients.
The influence of fucoidan on stability, adsorption and electrokinetic properties of ZnO and TiO2 suspensions
Authors: Matusiak Jakub , Grządka Elżbieta , Bastrzyk Anna , Pasieczna-Patkowska Sylwia 
Published: March 2021

AbstractStabilization of nano-oxide suspensions is a very important process. Nowadays, synthetic polymers are used to increase stability of the colloidal systems. However, this solution is not ecological and incompatible with the principles of green chemistry. Instead of synthetic polymers, their natural counterparts can be used. Herein, we present the use of natural bioactive polysaccharide—fucoidan as a stabilizer of nano-zinc(II) and nano-titanium(IV) oxide suspensions. These two oxides are commercially available and are widely used in the cosmetic and pharmaceutical industries. The turbidimetric studies (Turbiscan Lab) showed that the addition of fucoidan leads to the increase of stability and that the effect depends on the polymer concentration. To fully describe the systems’ stability, the adsorption (UV–Vis and FT-IR/PAS) and the electrokinetic properties (zeta potential and surface charge density) were studied. The obtained results indicate that fucoidan adsorbs by the electrostatic and non-electrostatic interactions on the used oxides forming the tight adsorption layer. The following paper thoroughly explains the stabilization mechanism of fucoidan toward the nano-oxide suspensions. Moreover, the presented results could be useful in the preparation of new cosmetic and pharmaceutical products containing nano-oxides.
COVID-19 vaccines: rapid development, implications, challenges and future prospects
Authors: Kashte Shivaji , Gulbake Arvind , El-Amin III Saadiq F. , Gupta Ashim 
Published: March 2021

AbstractCOVID-19 has affected millions of people and put an unparalleled burden on healthcare systems as well as economies throughout the world. Currently, there is no decisive therapy for COVID-19 or related complications. The only hope to mitigate this pandemic is through vaccines. The COVID-19 vaccines are being developed rapidly, compared to traditional vaccines, and are being approved via Emergency Use Authorization (EUA) worldwide. So far, there are 232 vaccine candidates. One hundred and seventy-two are in preclinical development and 60 in clinical development, of which 9 are approved under EUA by different countries. This includes the United Kingdom (UK), United States of America (USA), Canada, Russia, China, and India. Distributing vaccination to all, with a safe and efficacious vaccine is the leading priority for all nations to combat this COVID-19 pandemic. However, the current accelerated process of COVID-19 vaccine development and EUA has many unanswered questions. In addition, the change in strain of SARS-CoV-2 in UK and South Africa, and its increasing spread across the world have raised more challenges, both for the vaccine developers as well as the governments across the world. In this review, we have discussed the different type of vaccines with examples of COVID-19 vaccines, their rapid development compared to the traditional vaccine, associated challenges, and future prospects.
Emotional abuse interacts with borderline personality in adolescent inpatients with binge-purging eating disorders
Authors: Spiegel J. , Arnold S. , Salbach H. , Gotti E. G. , Pfeiffer E. , Lehmkuhl U. , Correll C. U. , Jaite C. 
Published: March 2021

Abstract
Purpose
Childhood abuse is associated with an increased risk of developing eating disorders (EDs) as well as personality disorders (PDs). However, their interaction is still uncertain, particularly in adolescents. This study investigates the correlations between childhood emotional neglect (CEN), childhood emotional abuse (CEA), and obsessive-compulsive and borderline personality styles in female adolescent inpatients with eating disorders (EDs).

Methods
One hundred and twenty-eight inpatients (ages 14-18) were assessed, 54 were diagnosed with restricting-type anorexia nervosa (AN-R) and 33 with a binge-purging ED [BP-ED; comprising patients with binge-purging type anorexia nervosa (AN-BP), n = 15, and bulimia nervosa (BN), n = 18]. Fifty healthy participants made up the control group (CG). CEN and CEA were assessed with the Childhood Trauma Questionnaire, while the Personality Style and Disorder Inventory was implemented to determine personality styles.

Results
A MANOVA revealed a significant main effect of CEA on spontaneous-borderline personality style [F(8,119) = 17.1, p < 0.001, η2 = 0.126], as well as a main effect of ED group on spontaneous-borderline [F(2,119) = 3.1, p = 0.048, η2 = 0.050]. A significant interaction between ED group, CEA, and spontaneous-borderline was found [F(2,119) = 3.5, p = 0.034, η2 = 0.055] with BP-ED showing significantly higher scores in CEA (9.3 ± 4.0) and in spontaneous-borderline (14.2 ± 6.2).

Conclusions
Considering CEA and borderline personality style in adolescent inpatients with BN or AN-BP may help improve the understanding of the etiology and maintenance of BP-ED and provide more effective treatment targets.

Level of evidence
Level III, case–control analytic study.
Railway wheel profile fine-tuning system for profile recommendation
Authors: Ye Yunguang , Vuitton Jonas , Sun Yu , Hecht Markus 
Published: March 2021

AbstractThis paper develops a wheel profile fine-tuning system (WPFTS) that comprehensively considers the influence of wheel profile on wheel damage, vehicle stability, vehicle safety, and passenger comfort. WPFTS can recommend one or more optimized wheel profiles according to train operators’ needs, e.g., reducing wheel wear, mitigating the development of wheel out-of-roundness (OOR), improving the shape stability of the wheel profile. Specifically, WPFTS includes four modules: (I) a wheel profile generation module based on the rotary-scaling fine-tuning (RSFT) method; (II) a multi-objective generation module consisting of a rigid multi-body dynamics simulation (MBS) model, an analytical model, and a rigid–flexible MBS model, for generating 11 objectives related to wheel damage, vehicle stability, vehicle safety, and passenger comfort; (III) a weight assignment module consisting of an adaptive weight assignment strategy and a manual weight assignment strategy; and (IV) an optimization module based on radial basis function (RBF) and particle swarm optimization (PSO). Finally, three cases are introduced to show how WPTFS recommends a wheel profile according to train operators’ needs. Among them, a wheel profile with high shape stability, a wheel profile for mitigating the development of wheel OOR, and a wheel profile considering hunting stability and derailment safety are developed, respectively.
USP11 suppresses CHK1 activation by deubiquitinating CLASPIN
Authors: Zhao Hongchang , Wang Zhifeng , Zhu Min , Liao Ji , Xu Xingzhi 
Published: March 2021

AbstractCLASPIN is an essential mediator of ATR-dependent CHK1 activation in the DNA replication checkpoint. K6-linked polyubiquitination of CLASPIN promotes its chromatin loading and subsequent CHK1 activation. Here, we found that ubiquitin-specific protease 11 (USP11) deubiquitinates the K6-linkage polyubiquitinated form of CLASPIN. Under steady-state conditions, USP11 interacts with CLASPIN, reducing CLASPIN K6-linked ubiquitination levels. In response to replication stress, USP11 is phosphorylated by ATR and subsequently disassociated from CLASPIN, promoting CLASPIN chromatin loading, CHK1 activation and ultimately genome stability. Taken together, our findings uncover a novel function of USP11 in negatively regulating CHK1 activation by suppressing CLASPIN chromatin loading.
Associations between the identity domains of future plans and education, and the role of a major curricular internship on identity formation processes
Authors: den Boer Liselotte , Klimstra Theo A. , Denissen Jaap J.A. 
Published: March 2021

ABSTRACTIntroductionExperiences during the last years of college could stimulate identity formation processes within and across the domains of future plans and education. In the present study, the first research question addressed how identity formation dimensions for education and future plans were associated with each other during the last years in education. The second research question addressed whether identity processes (i.e., identity levels, changes herein, and the associations among identity variables between and within domains) would be different for students who were doing an internship versus those who did not.MethodWe used a longitudinal design with three measurement occasions. Participants were Dutch psychology college students (N = 287; 83.3% women; M age = 21.8 years, SD = 2.0). We used two different self‐report instruments to measure identity processes (i.e., commitment and exploration) in the domains of future plans and education.ResultsWe found that commitments in the domains of future plans and education were significantly associated. Enrollment in a practical internship was largely unrelated to identity processes, as it did not explain individual differences in identity levels, changes herein and associations between and within domains.ConclusionsOur results suggest integration between educational identity and future plans for commitment processes. At a group level, a practical internship in itself did not explain individual differences in identity processes.
Cross-Sectional Study of Sexual Activity and Satisfaction Among Older Adult's ≥60 Years of Age
Authors: Stentagg Magnus , Skär Lisa , Berglund Johan Sanmartin , Lindberg Terese 
Published: March 2021

Abstract

Introduction
Despite the rapidly increasing population of older adults, little is currently known about sexual activity and sexual satisfaction among the oldest people.

Aim
The present study aimed to investigate sexual activity and sexual satisfaction among people of ≥60 years of age. We also examined whether sexual activity and sexual satisfaction were influenced by age, gender, cohabiting, socioeconomic factors, education, functional ability, and self-reported health.

Methods
We performed a descriptive analysis of self-stated sexual activity and sexual satisfaction among 1680 participants who were 60 years and older from the Swedish National Study on Aging and Care. Chi-square tests and logistic regression were used to analyze relationships between factors.

Main Outcome Measure
Sexual activity and sexual satisfaction.

Results
Among participants aged ≥90 years, about 10% were sexually active. Within the total study population, 46% (654/1680) were sexually active. Overall, sexually activity was more commonly reported by men (55%) than women (40%). However, men in all age cohorts reported sexual dissatisfaction more commonly than women. In the total sample, 24% (246/1680) reported dissatisfaction with their sex life. Sexual activity and sexual satisfaction were positively associated with self-reported health and cohabitation.

Conclusion
The present results suggest that sexual activity is present throughout life. For persons older than 90 years, about 10% of participants were sexually active, regardless of gender. Every third man reported dissatisfaction with his sex life. Women were more satisfied with their sex lives than men, and this difference varies more widely among age cohorts. These findings confirm that it is important that health professional take sexuality into account during caring encounters with older persons.