bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematics and conservation of an endemic radiation ofAccipiterhawks in the Caribbean islands
Authors: Catanach Therese A , Halley Matthew R , Allen Julie M , Johnson Jeff A , Thorstrom Russell , Palhano Samantha , Poor Thunder Chyna , Gallardo Julio C , Weckstein Jason D 
Published: June 2021

AbstractMore than one-third of the bird species found in the Caribbean are endemic to a set of neighboring islands or a single island. However, we have little knowledge of the evolutionary history of the Caribbean avifauna, and the lack of phylogenetic studies limits our understanding of the extent of endemism in the region. The Sharp-shinned Hawk (Accipiter striatus) occurs widely across the Americas and includes 3 endemic Caribbean taxa: venator on Puerto Rico, striatus on Hispaniola, and fringilloides on Cuba. These island populations have undergone extreme declines presumably due to ecosystem changes caused by anthropogenic factors, as well as due to severe hurricanes. Sharp-shinned Hawks, in general, and Caribbean Sharp-shinned Hawks, in particular, have not been placed in a modern phylogenetic context. However, the island taxa have historically been presumed to have some ongoing gene flow with mainland populations. Here we sequenced ultraconserved elements (UCEs) and their flanking regions from 38 samples, focusing on Caribbean taxa. Using a combination of UCEs, mitochondrial genome sequences, and single-nucleotide polymorphisms, we investigated the phylogenetic relationships among Caribbean lineages and their relationships to mainland taxa. We found that Caribbean Sharp-shinned Hawks are reciprocally monophyletic in all datasets with regard to mainland populations and among island taxa (with no shared mtDNA haplotypes) and that divergence in the NADH dehydrogenase 2 gene (ND2) between these mainland and island groups averaged 1.83%. Furthermore, sparse non-negative matrix factorization (sNMF) analysis indicated that Hispaniola, Puerto Rico, and mainland samples each form separate populations with limited admixture. We argue that our findings are consistent with the recognition of the 3 resident Caribbean populations as species-level taxa because nuclear and mitochondrial genetic data indicate reciprocal monophyly and have species-level divergences, there is no sharing of mitochondrial haplotypes among or between island taxa and those on the mainland; and they are diagnosable by plumage.
Perioperative Intravenous Lidocaine Infusion for Postoperative Analgesia in Patients Undergoing Surgery of the Spine: Systematic Review and Meta-Analysis
Authors: Licina Ana , Silvers Andrew 
Published: June 2021

Abstract

Objective
We conducted a systematic review and meta-analysis to examine the impact of perioperative intravenous lidocaine infusion on pain management scores, opioid consumption, adverse events, and hospital length of stay in patients undergoing spinal surgery.

Methods
We included randomized controlled trials evaluating the use of perioperative intravenous lidocaine in adult and pediatric patients undergoing spinal surgery. Primary outcomes were postoperative pain scores at rest and at 2, 4–6, 24, and 48 hours and adverse events attributable to lidocaine administration. We searched electronic databases from their inception to the present. We used Cochrane’s standard methods. We used a random-effects model to synthetize data. We conducted three subgroup analyses: patients undergoing major surgery vs patients undergoing minor surgery, patients with chronic pain conditions vs patients without, and adult vs pediatric patients.

Results
A total of eight studies were included that compared patients having intravenous lidocaine (n = 349) with controls (n = 343). Intravenous lidocaine administration was associated with significantly reduced visual analog pain scores at 2 hours (mean difference [MD] = −1.13), 4–6 hours (MD = −0.79), and 24 hours (MD = −0.50) postoperatively. In the adults, efficacy of treatment was extended to 48 hours (MD = −0.72). Perioperative intravenous lidocaine administration was associated with reduced perioperative opioid consumption at 24 and 48 hours, as well as decreased hospital length of stay.

Conclusion
Perioperative intravenous lidocaine infusion consistently improves analgesic measures in adult and pediatric populations in the first 24 hours, with an effective decrease in opioid consumption noted to 48 hours. These results are most generalizable in the adult population in the first 4–6 to 24 postoperative hours.
Leadership Competencies for Knowledge Translation in Public Health: A consensus study
Authors: Rodríguez-Feria Pablo , Flórez Luis Jorge Hernández , Czabanowska Katarzyna 
Published: June 2021

Abstract

Background
In 2010, 240 billion US dollars was invested worldwide to conduct research for health; unfortunately, 200 billion was misused in the production and reporting of the evidence researched. Universities could facilitate students to acquire leadership competencies to move well-conducted research findings into practical use; this could be an essential move to reduce the misuse of investment.

Methods
A literature review was done based on the Equator Network and Cochrane guidelines, followed by three Delphi rounds to select competencies.

Results
Eleven papers were analysed out of 1121 items and 39/78 identified competencies were prioritized to be presented in the Delphi. Four out of 12 participants accepted to be involved in this project, and 22 competencies reached consensus and stability after three rounds. This framework conceptualizes competencies as the knowledge, skills, attitudes and values. The competencies were framed in four domains: knowledge management, engage diverse others in public health initiatives, training and capacity building/change management and communication.

Conclusion
This framework offers guidance to universities when instructing students with leadership competencies for KT. This project emphasizes that effective leadership should include personal conscience and self-determination values.
Morphometry of the lateral orbitofrontal cortex is associated with eating dispositions in early adolescence: findings from a large population-based study
Authors: Hall Peter A , Best John R , Danckert James , Beaton Elliott A , Lee Jessica A 
Published: June 2021

AbstractEarly adolescence is a critical period for eating behaviors as children gain autonomy around food choice and peer influences increase in potency. From a neurodevelopmental perspective, significant structural changes take place in the prefrontal cortex during this time, including the orbitofrontal cortex (OFC), which is involved in socially contextualized decision-making. We examined the morphological features of the OFC in relation to food choice in a sample of 10 309 early adolescent children from the Adolescent Brain and Cognitive Development Study. Structural parameters of the OFC and insula were examined for relationships with two important aspects of food choice: limiting the consumption of fast/fried food and maximizing the consumption of nutritious foods. Raw, partially adjusted and fully adjusted models were evaluated. Findings revealed that a larger surface area of the lateral OFC was associated with higher odds of limiting fast/fried food consumption in raw [odds ratio (OR) = 1.07, confidence interval (CI): 1.02, 1.12, P = 0.002, PFDR = 0.012], partially adjusted (OR = 1.11, CI: 1.03, 1.19, P = 0.004, PFDR = 0.024) and fully adjusted models (OR = 1.11, CI: 1.03, 1.19, P = 0.006, PFDR = 0.036). In contrast, a larger insula volume was associated with lower odds of maximizing healthy foods in raw (OR = 0.94, CI: 0.91, 0.97, P &lt;0.001, PFDR = 0.003) and partially adjusted (OR = 0.93, CI: 0.88, 0.98, P = 0.008, PFDR = 0.048) models. These findings refine our understanding of the OFC as a network node implicated in socially mediated eating behaviors.
Pathways to Social Work Licensure: An Examination of Hawai′i’s Licensed Social Workers
Authors: Arndt Robin G , Kreif Theresa M , Stotzer Rebecca L 
Published: June 2021

Abstract
Few research studies have examined social work practitioners and their licensure practices and pathways, or how policies affect licensure choices. Pathways to licensure, particularly the process of movement from graduation to licensure, along with the type of license, and the length of time a license is held were analyzed using administrative data from a state agency responsible for professional licensure administration and two schools of social work in the same state. The analysis prioritized the review of individuals who have held or do hold multiple licenses. Results indicated (a) that the majority of people who pursue licensure do so shortly after graduation; (b) that once licensed, graduates maintain their licenses for long periods of time; (c) that the majority of graduates do not pursue licensure; and (d) that policy contexts and opportunities for licensure at different levels affect licensure decision making. The analysis resulted in detailed information regarding the decisions graduates are making to pursue their licenses, the impact of policy on licensure pathways, the intersection of jurisdictional policy and license mobility, and the process of how social workers move through various levels of licensure.
Spine Surgery Complications in the Ambulatory Surgical Center Setting
Authors: Cha Elliot D.K. , Lynch Conor P. , Hrynewycz Nadia M. , Geoghegan Cara E. , Mohan Shruthi , Jadczak Caroline N. , Parrish James M. , Jenkins Nathaniel W. , Singh Kern 
Published: June 2021

Study Design:
This was a systematic review study.

Purpose:
This study aims to review current literature to determine the rates of complications in relation to spine surgery in ambulatory surgery centers (ASC).

Background:
Recent improvements in anesthesia, surgical techniques, and technological advances have facilitated a rise in the use of ASC. Despite the benefits and lower costs associated with ASCs, there is inconsistent reporting of complication rates.

Methods:
This systematic review was completed utilizing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Pertinent studies were identified through Embase and PubMed databases using the search string (((“ambulatory surgery center”) AND “spine surgery”) AND “complications”). Articles were excluded if they did not report outpatient surgery in an ASC, did not define complications, were in a language other than English, were non-human studies, or if the articles were classified as reviews, book chapters, single case reports, or small case series (≤10 patients). The primary outcome was the frequency of complications with respect to various categories.

Results:
Our query identified 150 articles. After filtering relevance by title, abstract, and full text, 22 articles were included. After accounting for 2 studies that were conducted on the same study sample, a total of 11,245 patients were analyzed in this study. The most recent study reported results from May 2019. While 5 studies did not list their surgical technique, studies reported techniques including open (6), minimally invasive surgery (2), endoscopic (4), microsurgery (1), and combined techniques (4). The following rates of complications were determined: cardiac 0.29% (3/1027), vascular 0.25% (18/7116), pulmonary 0.60% (11/1839), gastrointestinal 1.12% (2/179), musculoskeletal/spine/operative 0.59% (24/4053), urologic 0.80% (2/250), transient neurological 0.67% (31/4616), persistent neurological 0.61% (9/1479), pain related 0.57% (20/3479), and wound site 0.68% (28/4092).

Conclusions:
After literature review, this is the first study to comprehensively analyze the current state of literature reporting on the complication profile of all ASC spine surgery procedures. The most common complications were gastrointestinal (1.12%) and the most infrequent were vascular (0.25%). Case reports varied significantly with regard to the type and rate of complications reported. This study provides complication profiles to assist surgeons in counseling patients on the most realistic expectations.
Soluble Suppression of Tumorigenicity-2 Associates With Ventilator Dependence in Coronavirus Disease 2019 Respiratory Failure
Authors: Alladina Jehan W. , Giacona Francesca L. , White Emma B. , Brait Kelsey L. , Abe Elizabeth A. , Michelhaugh Sam A. , Hibbert Kathryn A. , Januzzi James L. , Thompson B. Taylor , Cho Josalyn L. , Medoff Benjamin D. 
Published: June 2021

OBJECTIVES:
We hypothesize that elevated soluble suppression of tumorigenicity-2 concentrations, a marker of pulmonary epithelial injury, reflect ongoing lung injury in acute hypoxemic respiratory failure due to coronavirus disease 2019 and associate with continued ventilator dependence.

DESIGN:
We associated serial plasma soluble suppression of tumorigenicity-2 levels and markers of systemic inflammation including d-dimer, C-reactive protein, and erythrocyte sedimentation rate with 30-day mortality and ventilator dependence.

SETTING:
Adult medical ICUs and general medicine wards at an academic teaching hospital in Boston, MA.

PATIENTS:
Adult patients with severe acute respiratory syndrome coronavirus 2 infection and acute hypoxemic respiratory failure admitted to the ICU (n = 72) and non-ICU patients managed with supplemental oxygen (n = 77).

INTERVENTIONS:
Observational study from April 25 to June 25, 2020.

MEASUREMENTS AND MAIN RESULTS:
ICU patients had a higher baseline body mass index and median soluble suppression of tumorigenicity-2, d-dimer, and C-reactive protein concentrations compared with non-ICU patients. Among ICU patients, elevated baseline modified Sequential Organ Failure Assessment score and log (soluble suppression of tumorigenicity-2) were associated with 30-day mortality, whereas initial Pao
2/Fio
2 and markers of systemic inflammation were similar between groups. Only log (soluble suppression of tumorigenicity-2) associated with ventilator dependence over time, with the last measured log (soluble suppression of tumorigenicity-2) concentration obtained on ICU day 11.5 (interquartile range [7–17]) higher in patients who required reintubation or tracheostomy placement compared with patients who were successfully extubated (2.10 [1.89–2.26] vs 1.87 ng/mL [1.72–2.13 ng/mL]; p = 0.03). Last measured systemic inflammatory markers, modified Sequential Organ Failure Assessment score, and Pao
2/Fio
2 were not different between patients who were successfully extubated compared with those with continued ventilator dependence.

CONCLUSIONS:
Plasma soluble suppression of tumorigenicity-2 is a biomarker readily measured in blood that can provide dynamic information about the degree of a patient’s lung injury and real-time assessment of the likelihood of extubation success. Measures of systemic inflammation, illness severity, and oxygenation did not associate with ventilator outcomes.
Life-course Psychological Distress and Total Mortality by Middle Age
Authors: Batty G. David , Hamer Mark , Gale Catharine R. 
Published: June 2021

Background:
The onset of psychological distress most commonly occurs in adolescence and, in keeping with other exposures, is time-varying across the life course. Most studies of its association with mortality risk are, however, conducted in middle- and older-aged populations with a single baseline assessment. This may lead to an underestimation of the magnitude of distress–mortality relationship.

Methods:
We used data from the 1970 British Cohort Study, a prospective cohort study. Psychological distress and covariates were collected at ages 5, 10, and 26. Vital status was ascertained between ages 26 and 44 years.

Results:
Eighteen years of mortality surveillance of 5,901 individuals (3,221 women) gave rise to 74 deaths. After adjustment for a series of confounding factors which included early life socioeconomic status, birth characteristics, and cognition, relative to the unaffected group, distress in childhood only was associated with around a 50% elevation in mortality risk (hazard ratio = 1.45; 95% confidence interval = 0.84, 2.51), whereas distress in adulthood only was related to a doubling of risk (1.95; 0.90, 4.21). In study members with persistent distress symptoms (childhood and adulthood), there was a tripling of the death rate (3.10; 1.42, 6.74) (P value for trend across these categories: 0.002).

Conclusion:
The suggestion of a strong association between life-course distress and death warrants replication in a study with a greater number of events.
Obesity increases endometrial cancer risk in Chinese women with postmenopausal bleeding
Authors: Liu Fangzi , Cheung Eva C.W. , Lao Terence T. 
Published: June 2021

Abstract

Objective:
We examined the relationship between body mass index (BMI) at referral and subsequent diagnosis of endometrial cancer in a cohort of Chinese women presenting with postmenopausal bleeding, to determine whether BMI of 25 kg/m2 would serve to delineate women at increased risk of endometrial cancer.

Methods:
This cohort included 4,164 Chinese women referred for postmenopausal bleeding from 2002 to 2013. For all women, a medical history was taken, and physical examination, BMI measurement, transvaginal pelvic ultrasonography, and endometrial sampling were performed. Additional investigations were performed as indicated clinically. The presence of risk factors for endometrial cancer and histological diagnoses were compared among groups defined by the standard Asian BMI cut-off values.

Results:
Within the cohort, 868 (20.8%) were overweight (BMI 23-24.9 kg/m2) and 1,611 (38.7%) were obese (BMI ≥25 kg/m2), and 162 (3.9%) had endometrial cancer. The prevalence of endometrial cancer correlated with BMI category (P < 0.001). On multivariate analysis, BMI ≥25 kg/m2 was independently associated with 1.57 times risk of endometrial cancer (95% CI 1.13-2.20, P = 0.008) compared with BMI less than 25 kg/m2.

Conclusion:
When managing postmenopausal bleeding in Chinese women, the Asian BMI standard for obesity at 25 kg/m2 identified 51% of endometrial cancers in this group and denoted a 57% increased risk of endometrial cancer. Thus obesity could be used to triage women presenting with postmenopausal bleeding for prioritized investigations.
Drug-induced sarcoidosis-like reactions
Authors: Miedema Jelle , Nunes Hilario 
Published: June 2021

Purpose of review
Sarcoidosis is a complex granulomatous disease of unknown cause. Several drug categories are able to induce a systemic granulomatous indistinguishable from sarcoidosis, known as drug-induced sarcoidosis-like reaction (DISR). This granulomatous inflammation can resolve if the medication is discontinued. In this review, we discuss recent literature on medication associated with DISR, possible pathophysiology, clinical features, and treatment.

Recent findings
Recently, increasing reports on DISR have expanded the list of drugs associated with the systemic granulomatous eruption. Most reported drugs can be categorized as combination antiretroviral therapy, tumor necrosis factor-α antagonist, interferons, and immune checkpoint inhibitors, but reports on other drugs are also published. The proposed mechanism is enhancement of the aberrant immune response which results in systemic granuloma formation. It is currently not possible to know whether DISR represents a separate entity or is a triggered but ‘true’ sarcoidosis.
As DISRs may cause minimal symptoms, treatment is not always necessary and the benefits of continuing the offending drug should be weighed against clinical symptoms and organ dysfunction. Treatment may involve immunosuppressive medication that is used for sarcoidosis treatment.

Summary
In this article, we review recent insights in DISR: associated drug categories, clinical presentation, diagnosis, and treatment. Additionally, we discuss possible mechanisms of DISR which can add to our knowledge of sarcoidosis pathophysiology.
Interstitial pneumonia with autoimmune features: from research classification to diagnosis
Authors: Glenn Laura M. , Pugashetti Janelle V. , Oldham Justin , Corte Tamera J. 
Published: June 2021

Purpose of review
The term interstitial pneumonia with autoimmune features (IPAF) was first proposed by an international task force in 2015 as a research classification to standardise nomenclature regarding patients with idiopathic interstitial pneumonia and features of connective tissue disease. However, how the use of this term and its proposed definition translates to clinical practice remains uncertain. This review will provide a comprehensive overview of studies of IPAF cohorts to date, discuss the consideration of IPAF as a distinct diagnostic entity and outline a suggested approach to patient management.

Recent findings
Considerable heterogeneity exists between published IPAF cohorts, with some cohorts exhibiting similarities to those with connective tissue disease-associated interstitial lung disease (CTD-ILD), and others more similar to idiopathic interstitial pneumonias including idiopathic pulmonary fibrosis (IPF). Little data exist to inform the management of patients who fulfil the IPAF criteria. Preliminary data supports pragmatic management of these patients as having a working clinical diagnosis of either idiopathic interstitial pneumonia or CTD-ILD. Future research studies into this approach are required.

Summary
The term IPAF, and its definition, have been of fundamental benefit to facilitating research in this diverse patient group. However, to date, there remain many unanswered questions regarding their natural histories and response to treatment.
Multiple Gastrointestinal Symptoms Are Associated With Chemotherapy-Induced Nausea in Patients With Breast Cancer
Authors: Singh Komal P. , Kober Kord M. , Ernst Brenda , Sachdev Jasgit , Brewer Melanie , Zhu Qiyun , Gu Haiwei , Melisko Michele , Paul Steven M. , Cooper Bruce A. , Hammer Marilyn , Conley Yvette P. , Levine Jon D. , Miaskowski Christine 
Published: June 2021

Background
Unrelieved chemotherapy-induced nausea (CIN) is a significant problem for patients with breast cancer (BC).

Objective
In a sample of patients with BC who were assessed before their second or third cycle of chemotherapy, study purposes were to evaluate for the occurrence, severity, frequency, and distress associated with CIN; evaluate for differences in demographic and clinical characteristics and gastrointestinal (GI) symptom occurrence rates between patients who did and did not report CIN; and determine which demographic, clinical, and symptom characteristics were associated with the occurrence of CIN.

Methods
Patients completed demographic and clinical questionnaires and the Memorial Symptom Assessment Scale for nausea and common GI symptom assessments. Univariate analyses evaluated for differences in demographic and clinical characteristics and GI symptom occurrence between patients who did and did not report CIN. Multiple logistic regression analysis evaluated for characteristics associated with CIN.

Results
Of the 532 patients with BC, 47.2% reported CIN occurrence. Characteristics associated with CIN group membership were poorer functional status, receipt of chemotherapy on a 14-day cycle, and higher occurrence rates of 5 GI symptoms (ie, dry mouth, vomiting, constipation, change in the way food tastes, and lack of appetite; all P < .001).

Conclusions
Unrelieved CIN is a common symptom in patients with BC. This study is the first to demonstrate that 5 co-occurring GI symptoms were associated with CIN occurrence.

Implications for Practice
This study identified new risk factors for CIN occurrence in patients with BC. Clinicians may be able to initiate additional interventions to alleviate CIN.