bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Clinical Trial to Evaluate the Efficacy of α-Viniferin in Staphylococcus aureus – Specific Decolonization without Depleting the Normal Microbiota of Nares
Authors: RAHIM MD ABDUR , SEO HOONHEE , KIM SUKYUNG , JEONG YOON KYOUNG , TAJDOZIAN HANIEH , KIM MIJUNG , LEE SAEBIM , SONG HO-YEON 
Published: March 2021

Abstract

Staphylococcus aureus is currently a significant multidrug-resistant bacterium, causing severe healthcare-associated and community-acquired infections worldwide. The current antibiotic regimen against this pathogen is becoming ineffective due to resistance, in addition, they disrupt the normal microbiota. It highlights the urgent need for a pathogen-specific drug with high antibacterial efficacy against S. aureus. α-Viniferin, a bioactive phytochemical compound, has been reported to have excellent anti-Staphylococcus efficacy as a topical agent. However, so far, there were no clinical trials that have been conducted to elucidate its efficacy. The present study aimed to investigate the antibacterial efficacy of α-viniferin against S. aureus in a ten-day clinical trial. Based on the results, α-viniferin showed 50% minimum inhibitory concentrations (MIC50 values) of 7.8 μg/ml in culture broth medium. α-Viniferin was administered in the nares three times a day for ten days using a sterile cotton swab stick. Nasal swab specimens were collected before (0 days) and after finishing the trial (10th day), and then analyzed. In the culture and RT-PCR-based analysis, S. ureus was reduced significantly: 0.01. In addition, 16S ribosomal RNA-based amplicon sequencing analysis showed that S. aureus reduced from 51.03% to 23.99% at the genus level. RNA-seq analysis was also done to gain insights into molecular mechanisms of α-viniferin against S. aureus, which revealed that some gene groups were reduced in 5-fold FC cutoff at two times MIC conditions. The study results demonstrate α-viniferin as a potential S. aureus-specific drug candidate.
Microbiota: A Missing Link in The Pathogenesis of Chronic Lung Inflammatory Diseases
Authors: MAGRYŚ AGNIESZKA 
Published: March 2021

Abstract
Chronic respiratory diseases account for high morbidity and mortality, with asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) being the most prevalent globally. Even though the diseases increase in prevalence, the exact underlying mechanisms have still not been fully understood. Despite their differences in nature, pathophysiologies, and clinical phenotypes, a growing body of evidence indicates that the presence of lung microbiota can shape the pathogenic processes underlying chronic inflammation, typically observed in the course of the diseases. Therefore, the characterization of the lung microbiota may shed new light on the pathogenesis of these diseases. Specifically, in chronic respiratory tract diseases, the human microbiota may contribute to the disease’s development and severity. The present review explores the role of the microbiota in the area of chronic pulmonary diseases, especially COPD, asthma, and CF.
Mimesis y bruma en el contexto educativo
Authors: Villacorta-Guzmán Juan , Soliz-Gemio José 
Published: March 2021

El presente artículo tiene como base la experiencia docente de muchos años, además de la reflexión académica y cotidiana de los autores, los cuales al provenir de una fuente primaria diferente en lo académico se encuentran y reflexionan a la luz de un momento histórico maravilloso.
El artículo parte de una combinación entre teoría y práctica, la cual a su vez permite visualizar una serie de elmentos desafiantes y motivantes, los autores por lo tanto no dan respuestas, sino que intentan ayudar a una profundización de la actitud dialógica (Freire y Morin) como elemento central de la refelxividad desafiante en medio de la mimesis y la bruma educativa.
Pendidikan Politik Bagi Generasi Milenial di SMA Global Prestasi, Kalimalang, Bekasi Barat
Authors: Damayanti Angel , Siahaan Chontina , Robertua Verdinand , Sari Indah Novita , Narida Marshelia Gloria 
Published: March 2021

Abstrak
Berita hoax dan black campaignpada masa kampanye menjelang pemilihan Presiden dan Wakil Presiden serta anggota legislatif tahun 2019 ini banyak disebarluaskan melalui media sosial. Menariknya, pengguna media sosial tersebut banyak berasal dari remaja yang sedang duduk di Sekolah Menengah Atas (SMA) dan beberapa di antaranya merupakan pemilih pemula. Oleh karena itu, tulisan ini bertujuan untuk menjelaskan kegiatan Pengabdian Kepada Masyarakat (PKM) yang dilakukan oleh Fakultas Ilmu Sosial dan Ilmu Politik Universitas Kristen Indonesia kepada siswa-siswi SMA Global Prestasi, Kalimalang, Bekasi dalam bentuk pendidikan politik bagi generasi milenial. Kegiatan PKM tersebut dilakukan dengan memberikanpengarahan kepada siswa-siswi SMA Global Prestasi untuk memanfaatkan hak politik mereka sambil tetap berpikir kritis dan bersikap cerdas dalam menyikapi sejumlah berita hoax dan kampanye hitam yang dikaitkan dengan isu-isu politik di Indonesia.
Kata kunci: Pendidikan politik, pemilih pemula, berita hoax, media sosial
Abstract
Many hoaxes and black campaigns during the campaign period ahead of the 2019 Election of President and Vice-President as well as legislative members are widely disseminated through social media. Interestingly, social media users mostly come from teenagers who are high school (SMA) students and some of them are beginner voters. Therefore this paper aims to explain the Community Service (PKM) activities carried out by the Faculty of Social and Political Sciences of the Christian University of Indonesia to students of Global Prestasi High School, Kalimalang, Bekasi in the form of political education for the millennial generation. The PKM activity is carried out by giving education and direction to Global Prestasi High School students to take advantage of their political rights while still thinking critically and being smart at the same time in responding to a number of hoaxes and black campaigns that are associated with political issues in Indonesia.
Keywords: Political education, novice voters, hoax news, social media
Identifikasi Rencana Pelaksanaan Pembelajaran Guru Kimia pada Kegiatan Sosialisasi Pengembangan Kompetensi Terintegrasi Pengembangan Ranah Afektif
Authors: Harefa Nelius , Simanjuntak Familia Novita , Simatupang Nova Irawati , Sumiyati Sumiyati , Sormin Elferida , Purba Leony Sanga Lamsari , Azzahra St Fatimah 
Published: March 2021

RPP merupakan instrumen perencanaan pelaksanaan pembelajaran yang disusun guru setiap semester. Instrumen ini dapat dimanfaatkan sebagai salah satu alat kontrol pelaksanaan pembelajaran. Pada kegiatan ini dilakukan sosialisasi pengembangan kompetensi guru kimia terintegrasi ranah afektif, dimana RPP menjadi salah satu indikator dan output kegiatan. Berdasarkan hasil analisis data identifikasi, 100% guru telah lengkap dalam memuat identitas mata pelajaran; 60,29% guru telah merumuskan indikator pada kategori sesuai seluruhnya; 50% guru telah merumuskan tujuan pembelajaran pada kategori sesuai seluruhnya; 56,86% guru mampu memilih materi ajar pada kategori sesuai sebagian; 42,64% guru mampu memilih sumber belajar pada kategori sebagian; 51,47% guru mampu memilih media belajar pada kategori sesuai sebagian; 49,02% guru mampu memilih metode pembelajaran pada kategori sesuai seluruhnya; 48,24% guru mampu merancang skenario pembelajaran pada kategori sesuai sebagian; dan 48,53% guru mampu membuat rancangan penilaian autentik pada kategori sesuai sebagian. Secara umum, guru kimia yang menjadi sampel pada kegiatan tersebut telah memiliki kompetensi dasar menyusun RPP berbasis problem based learning dan project based learning.
Kata Kunci: Guru Kimia; Kompetensi; Ranah Afektif; RPP
Pengembangan Daerah Pariwisata melalui Pemanfaatan Upacara Adat Rambu Solo Kabupaten Toraja Utara
Authors: Rilatupa James , Siahaan Uras , Sudarwani Margareta M. 
Published: March 2021

Upacara penguburan telah menjadi ikon yang sangat penting bagi pariwisata di Toraja, terutama Toraja Utara. Seluruh perhatian penduduk, termasuk Pemerintah Daerah Toraja Utara akan terpusat kepada kegiatan ritual ini. Bangunan Rumah (Tongkonan) dan Lumbung Padi (Alang) tetap terpelihara dan dijaga untuk melaksanakan upacara tersebut, sehingga keberadaan Rumah tradisional tersebut tetap terjaga keberlanjutannya. Dalam penelitian tentang pelestarian bangunan upacara pemakaman ini telah disampaikan prinsip konservasi dan revitalisasi bangunan upacara tersebut. Dalam Kegiatan Pengabdian Pada Masyarakat, tim PPM Program studi Magister Arsitektur PPs UKI telah dilakukan beberapa penyuluhan tentang masalah konservasi dan revitalisasi KomplekUpacara Pemakaman tersebut. Tradisi upacara pemakaman tersebut juga membawa dampak negative pada pemakaian lahan yang luas, masalah pelestarian lingkungan dan penggunaan bahan bambu yang tidak terbatas, yang seharusnya dapat dilestarikan dan dibudidayakan. Selain itu juga, teknik perawatan bangunan dan pemakaian bahan lain yang lebih berkelanjutan akan menjadi salah satu cara pelestarian dan budidaya tanaman bambu. Dengan pengembangan teknik membangun dan system pelaksanaan pemakaman, maka tradisi ini tetap akan terpelihara dan biaya upacara pemakaman dapa tmenjadi alternative penghematan biaya upacara pemakaman.

Kata Kunci: Upacara Pemakaman, Pelestaran Bangunan dan Rambu Solo
Penyuluhan Pentingnya Pendaftaran Tanah Desa Binaan Kecamatan Pematang Sidamanik, Kabupaten Simalungan
Authors: Tehupeiory Aartje , Widiyani I Dewa Ayu , Tobing Gindo L , Napitupulu Diana 
Published: March 2021

Pentingnya Pendaftaran Tanah dilaksanankan di Desa Binaan Kecamatan Pematang Siantar, Kabupaten Simalungan selama 2 hari yakni tanggal 14, 15 agustus 2019. Dilaksanakan dalam bentuk penyuluhan Hukum di bidang Hukum Pertanahan, bertujuan untuk memberikan pengetahuan dan kesadaran pada masayarakat pentingnya pendafatran tanah bagi masyarakat untuk mendapatkan kepastian hukum bagi tanahnya yang dimiliki sehingga menimbulkan rasa mantap dan rasa aman bagi masyarakat yang memiliki tanah yang dihaki. Selanjutnya ada perlindungan hukum untuk untuk mencengah gangguan dan penguasaan sesama warga masyarakat. Dengan alat bukti yang dihasilkan pada akhir proses pendaftaran tanah berupa buku tanah dan sertifikat tanah yang terdiri atas salinan buku tanah dan surat ukur. Dari hasil kegiatan dapat diperoleh data bahwa masyarakat kecamatan Sidamanik belum memahami pentingnya pendaftaran tanah, masyarakat merasa aman saja dengan sikon selama ini, karena kurangnya sosialisasi yang diberikan kepada masyarakat, sementara kebijakan pemerintah presiden Jokowi tahun 2018 sudah mengeluarkan Peraturan Menteri Agraria dan Tata Ruang/Kepala BPN Nomor 6 Tahun 2018 Tentang Pendaftaran Sistematis Lengkap (PTSL) program percepatan pendaftaran tanah bagi masyarakat.
Kata Kunci: Pentingnya; Pendaftaran; Tanah
Peningkatan Pemahaman Masyarakat tentang Teknis Perbaikan dan Pelebaran Jembatan Penyeberangan Sungai Kecil di Kelurahan Cawang
Authors: Hutabarat L.E. , P Simanjuntak. , A.S Mulyani , R.M Simanjuntak 
Published: March 2021

Kawasan hunian di Kelurahan Cawang membutuhkan penataan agar lebih baik dan dapat mendekati pola standar hunian yang layak. Penataan lingkungan kawasan seperti ini perlu dilaksanakan secara berkelanjutan karena seiring dengan berjalannya waktu kawasan perkotaan akan mengalami keterbatasan ruang kota, permukiman yang padat, sistem sanitasi yang buruk serta minimnya ruang publik masyarakat. Salah satu sarana yang dapat diandalkan dalam pergerakan masyarakat di kelurahan ini diantaranya jembatan penyebrangan yang sering dilalui warga untuk keperluan sehari-hari. Peningkatkan pemahaman masyarakat tentang penataan lingkungan di kawasan Kelurahan Cawang dilaksanakan melalui kegiatan PKM Prodi Teknik Sipil FT UKI berupa pendampingan teknis untuk pelebaran jembatan selama total 120 jam yang dimulai dari survei, perencanaan, konsultasi dan asistensi, finalisasi gambar teknis, penyusunan tata kerja, serta persiapan pelaksanaan termasuk pelatihan tenaga kerja. Hasil pendampingan ini telah meningkatkan kesadaran masyarakat dalam memahami konsep dan pengertian kondisi lingkungan secara fisik yang aman, sehat dan nyaman.
Kata Kunci: penataan lingkungan, pendampingan teknis, pelebaran jembatan Cawang
PENINGKATAN LITERASI TERHADAP LEMBAGA JASA KEUANGAN BANK PADA MASYARAKAT KELURAHAN CAWANG JAKARTA TIMUR
Authors: Purnama Riwandari Juniasti , Edison Siregar  , Lis Sintha Oppusunggu  , Fery Tobing  
Published: March 2021

Banyak masyarakat telah mengenal lembaga perbankan namun belum semua mampu mengakses bank dan memanfaatkan produk dan jasa perbankan serta paham akan risiko yang dihadapi. Melalui kegiatan Pengabdian kepada Masyarakat di Kelurahan Cawang Jakarta Timur dilakukan edukasi keuangan untuk meningkatkan literasi keuangan masyarakat di Kelurahan Cawang Jakarta Timur terhadap lembaga jasa keuangan bank, produk jasa lembaga jasa keuangan, cara mengakses lembaga keuangan khususnya perbankan, tentang manfaat serta risiko menggunakan produk lembaga jasa keuangan, termasuk memberikan pengetahuan bagaimana mengajukan kredit ke bank, pengetahuan tentang peran Otoritas Jasa Keuangan (OJK) dan Lembaga Penjamin Simpanan (LPS). Metode yang dilakukan adalah melakukan edukasi keuangan dan untuk melihat dampak atas materi yang disampaikan, dilakukan evaluasi berupa pre-test dan post test pada peserta yang hadir di kelurahan tersebut. Hasil PkM menunjukkan bahwa literasi peserta PkM di Kelurahan Cawang Jakarta Timur sudah cukup baik, karena telah mengenal OJK. LPS dan bank serta telah bertransaksi di bank. Setelah dilakukan edukasi keuangan 61,30% peserta mengalami peningkatan literasi. Peningkatan literasi juga ditentukan oleh jenjang pendidikan, usia dan gender. Peserta PkM dapat dikatakan telah memiliki pengetahuan dan keyakinan tentang lembaga jasa keuangan serta produk dan jasa keuangan, termasuk fitur, manfaat dan risiko, hak dan kewajiban terkait produk dan jasa keuangan.

Kata kunci: edukasi keuangan; literasi keuangan; perbankan
Metalenses for subwavelength imaging
Authors: Baryshnikova K V , Kharintsev S S , Belov P A , Ustimenko N A , Tretyakov S A , Simovski C R 
Published: March 2021

AbstractDevices that form an optical image with a subwavelength resolution in real time – metalenses – are considered. Such devices either operate with near optical fields or convert near fields into wave fields. As a result, the spatial resolution of these devices is not limited by the diffraction limit. At the same time, the image is formed at a considerable distance from the object, which distinguishes near-field metalenses from the instruments used in near-field probe microscopy. Metalenses are implemented based on metamaterials or their two-dimensional analogs, metasurfaces. Historically, this line of research was based on the so-called perfect lens, the concept of which did not withstand experimental verification but gave impetus to the development of real metalenses. Depending on the device and principle of operation, metalenses are called either superlenses or hyperlenses.
Triglyceride Glucose Index Is Associated With Arterial Stiffness and 10-Year Cardiovascular Disease Risk in a Chinese Population
Authors: Guo Wen , Zhu Wenfang , Wu Juan , Li Xiaona , Lu Jing , Qin Pei , Zhu Cheng , Xu Nianzhen , Zhang Qun 
Published: March 2021

Background: Insulin resistance (IR) is a significant risk factor for cardiovascular disease (CVD). In this study, the association of the triglyceride glucose (TyG) index, a simple surrogate marker of IR, with arterial stiffness and 10-year CVD risk was evaluated.Methods: A total of 13,706 participants were enrolled. Anthropometric and cardiovascular risk factors were determined in all participants, while serum insulin levels were only measured in 955 participants. Arterial stiffness was measured through brachial-ankle pulse wave velocity (baPWV), and 10-year CVD risk was evaluated using the Framingham risk score.Results: All participants were classified into four groups according to the quartile of the TyG index. BaPWV and the percentage of participants in the 10-year CVD risk categories significantly increased with increasing quartiles of the TyG index. Logistic regression analysis showed that the TyG index was independently associated with a high baPWV and 10-year CVD risk after adjusting for traditional CVD risk factors. The area under the receiver operating characteristics curve (AUROC) of the TyG index for predicting a high baPWV was 0.708 (95%CI 0.693–0.722, P &lt; 0.001) in women, higher than that in men. However, the association of the homeostatic model assessment of IR (HOMA-IR) with a high baPWV and the 10-year CVD risk was absent when adjusting for multiple risk factors in 955 participants.Conclusions: The TyG index is independently associated with arterial stiffness and 10-year CVD risk.
Automatic Detection for Multi-Labeled Cardiac Arrhythmia Based on Frame Blocking Preprocessing and Residual Networks
Authors: Li Zicong , Zhang Henggui 
Published: March 2021

Introduction: Electrocardiograms (ECG) provide information about the electrical activity of the heart, which is useful for diagnosing abnormal cardiac functions such as arrhythmias. Recently, several algorithms based on advanced structures of neural networks have been proposed for auto-detecting cardiac arrhythmias, but their performance still needs to be further improved. This study aimed to develop an auto-detection algorithm, which extracts valid features from 12-lead ECG for classifying multiple types of cardiac states.Method: The proposed algorithm consists of the following components: (i) a preprocessing component that utilizes the frame blocking method to split an ECG recording into frames with a uniform length for all considered ECG recordings; and (ii) a binary classifier based on ResNet, which is combined with the attention-based bidirectional long-short term memory model.Result: The developed algorithm was trained and tested on ECG data of nine types of cardiac states, fulfilling a task of multi-label classification. It achieved an averaged F1-score and area under the curve at 0.908 and 0.974, respectively.Conclusion: The frame blocking and bidirectional long-short term memory model represented an improved algorithm compared with others in the literature for auto-detecting and classifying multi-types of cardiac abnormalities.
Burial Ages Imply Miocene Uplift of Lu Mountain in East China due to Crustal Shortening
Authors: Han Zhiyong , Pan Rouxian , Li Xusheng , Liu Yujia , Li Yufang , Wang Xianyan 
Published: March 2021

Confined by the eastern and western boundary faults, Lu Mountain has long been considered a block mountain uplifted due to Mesozoic and Cenozoic crustal deformation in East China. However, the formation and evolution of this block mountain are still debated. In this study, the eastern boundary fault is investigated to confirm the tectonic style of the block mountain. In addition, the burial ages of sediments on the fans of the eastern piedmont are measured by 26Al/10Be dating to evaluate the denudation rate. Field evidence indicates the presence of a reverse fault (Xingzi reverse fault) acting as the eastern boundary fault, which demonstrates that the block mountain is not a horst as once thought but an extrusion structure. Corrected 26Al/10Be burial ages show that the sediments on the high-level fans were deposited at approximately 1.1–1.2 Ma, which indicates denudation rates ranging from 0.033 to 0.082 m/kyr. The vertical displacement along the Xingzi reverse fault is estimated to be at least 1,100 m. The hanging wall could have been eroded to its present position within 13–33 Myr at the above denudation rates. Combining our results with regional geological and geomorphological evidence, we suggest that Lu Mountain was mainly uplifted in the Miocene due to crustal compression deformation, which may have been a response to the movement of the Pacific plate.
Cytokine Profiles and Antibody Response Associated to Choclo Orthohantavirus Infection
Authors: Salinas Tybbysay P. , Garrido Jose L. , Salazar Jacqueline R. , Gonzalez Publio , Zambrano Nicole , Fuentes-Villalobos Francisco , Bravo Felipe , Fica-Leon Victor , Salas-Burgos Alexis , Calvo Mario , Alvarez Raymond , Armien Blas , Barria Maria Ines 
Published: March 2021

BackgroundNew World Hantaviruses (NWHs) are the etiological agent underlying hantavirus cardiopulmonary syndrome (HCPS), a severe respiratory disease with high mortality rates in humans. In Panama, infections with Choclo Orthohantavirus (CHOV) cause a much milder illness characterized by higher seroprevalence and lower mortality rates. To date, the cytokine profiles and antibody responses associated with this milder form of HCPS have not been defined. Therefore, in this study, we examined immune serological profiles associated with CHOV infections.MethodsFor this retrospective study, sera from fifteen individuals with acute CHOV-induced HCPS, were analyzed alongside sera from fifteen convalescent phase individuals and thirty-three asymptomatic, CHOV-seropositive individuals. Cytokine profiles were analyzed by multiplex immunoassay. Antibody subclasses, binding, and neutralization against CHOV-glycoprotein (CHOV-GP) were evaluated by ELISA, and flow cytometry.ResultsHigh titers of IFNγ, IL-4, IL-8, and IL-10 serum cytokines were found in the acute individuals. Elevated IL-4 serum levels were found in convalescent and asymptomatic seropositive individuals. High titers of IgG1 subclass were observed across the three cohorts analyzed. Neutralizing antibody response against CHOV-GP was detectable in few acute individuals but was strong in both convalescent and asymptomatic seropositive individuals.ConclusionA Th1/Th2 cytokine signature is characteristic during acute mild HCPS caused by CHOV infection. High expression of Th2 and IL-8 cytokines are correlated with clinical parameters in acute mild HCPS. In addition, a strong IL-4 signature is associated with different cohorts, including asymptomatic individuals. Furthermore, asymptomatic individuals presented high titers of neutralizing antibodies.