bluuebunny/crossref_metadata_2025_split huggingface dataset:
GraspVDN: scene-oriented grasp estimation by learning vector representations of grasps
Authors: Dong Zhipeng , Tian Hongkun , Bao Xuefeng , Yan Yunhui , Chen Fei 
Published: July 2021

AbstractGrasp estimation is a fundamental technique crucial for robot manipulation tasks. In this work, we present a scene-oriented grasp estimation scheme taking constraints of the grasp pose imposed by the environment into consideration and training on samples satisfying the constraints. We formulate valid grasps for a parallel-jaw gripper as vectors in a two-dimensional (2D) image and detect them with a fully convolutional network that simultaneously estimates the vectors’ origins and directions. The detected vectors are then converted to 6 degree-of-freedom (6-DOF) grasps with a tailored strategy. As such, the network is able to detect multiple grasp candidates from a cluttered scene in one shot using only an RGB image as input. We evaluate our approach on the GraspNet-1Billion dataset and archived comparable performance as state-of-the-art while being efficient in runtime.
Early Holocene aeolian sediments in southwestern Crete−preliminary results
Authors: Kirsten Fabian , Fülling Alexander , Heinrich Susann , Schneider Birgit , Heinrich Jürgen 
Published: July 2021

AbstractThe soilscapes along the southern and western coast of Crete (Greece) are dominated by coarse-grained reddish-brown slope sediments whose natural (pre-anthropogenic) configuration and properties are difficult to reconstruct due to the long history of intense land use. As a consequence, datable terrestrial sediment archives of pre-anthropogenic genesis are scarce. We present preliminary results of a study performed on an accumulation within an alluvial fan south of Stomio Bay in southwestern Crete. The studied profile is located in a small depression and is composed of a sequence of sandy to silty yellowish-brown calcareous sediments overlying coarse-grained slope sediments, including a fossil topsoil horizon. Based on macroscopic, micromorphological, geochemical, geophysical and mineralogical analysis, we interpret the fine-grained sediments to have a local aeolian origin. OSL dating indicates a final deposition phase during the early Holocene. Considering the scarcity of early Holocene terrestrial archives in Crete, the analysed profile provides valuable data for the reconstruction of landscape dynamics and paleoecological conditions as well as soil-sediment configurations during this time period. Additional research is needed to address the specific source area(s) as well as the ages of the deposition of slope sediments and formation of the fossil topsoil.
Global partnerships in governing labour migration: the uneasy relationship between the ILO and IOM in the promotion of decent work for migrants
Authors: Piper Nicola , Foley Laura 
Published: July 2021

AbstractThis paper examines the multi-actor and multi-sited character of global labour migration governance as a sphere in which various organisations seek influence on the direction of global policy via various methods. We focus on the relational dynamics between the two key organisations which engage in the governance of labour migration, yet which have fundamentally different mandates and modes for governing: the ILO and the IOM. This paper contributes to the existing literature on global migration governance and the role of international organisations by applying the concept of ‘global partnerships’ to our examination of the relationship between those two key international organisations in the field of migration. We characterise the evolving ILO–IOM global partnership as an uneasy alliance along a “competition/clash-cooperation spectrum” and argue that, in order to manage the competing-cooperating dynamics, a type of strategic ILO–IOM partnership has emerged, an alliance which has also been driven by the blurring of public and private realms in new global migration governing forms and formats. The ultimate question raised by these developments is whether this global partnership will promote or obstruct the advancement of the decent work policy agenda for migrant workers.
Determinants of urban sprawl in Latin America: evidence from Santiago de Chile
Authors: Silva Cristian , Vergara-Perucich Francisco 
Published: July 2021

AbstractUrban sprawl has been widely discussed in regard of its economic, political, social and environmental impacts. Consequently, several planning policies have been placed to stop—or at least restrain—sprawling development. However, most of these policies have not been successful at all as anti-sprawl policies partially address only a few determinants of a multifaceted phenomenon. This includes processes of extended suburbanisation, peri-urbanisation and transformation of fringe/belt areas of city-regions. Using as a case study the capital city of Chile—Santiago—thirteen determinantsof urban sprawl are identified as interlinked at the point of defining Santiago's sprawling geography as a distinctive space that deserves planning and policy approaches in its own right. Unpacking these determinants and the policy context within which they operate is important to better inform the design and implementation of more comprehensive policy frameworks to manage urban sprawl and its impacts.
Matching Pragmatic Lithic Analysis and Proper Data Architecture
Authors: Contreras Daniel A. , Batist Zachary , Zogheib Ciara , Carter Tristan 
Published: July 2021

AbstractThe documentation and analysis of archaeological lithics must navigate a basic tension between examining and recording data on individual artifacts or on aggregates of artifacts. This poses a challenge both for artifact processing and for database construction. We present here an R Shiny solution that enables lithic analysts to enter data for both individual artifacts and aggregates of artifacts while maintaining a robust yet flexible data structure. This takes the form of a browser-based database interface that uses R to query existing data and transform new data as necessary so that users entering data of varying resolutions still produce data structured around individual artifacts. We demonstrate the function and efficacy of this tool (termed the Queryable Artifact Recording Interface [QuARI]) using the example of the Stelida Naxos Archaeological Project (SNAP), which, focused on a Paleolithic and Mesolithic chert quarry, has necessarily confronted challenges of processing and analyzing large quantities of lithic material.
Droits de l'homme et anthropogenèse du trans/posthumain. La « forme humaine » et les droits de l'homme : quels droits pour le trans/posthumain ?
Authors: Boarini Serge 
Published: July 2021

RésuméAux termes de l'article premier de la Déclaration du 26 août 1789, ne peut disposer des droits de l'homme que celui ou celle qui naît homme. La naissance, c'est-à-dire la manifestation d'un corps selon des lois naturelles dans un monde social, est la condition par laquelle un être advient à la personnalité. Si une longue tradition, étudiée ici, attribue l'identité humaine à ce qui possède à la naissance une « forme humaine », il reste à déterminer ce que désigne cette « forme », et à examiner si elle peut s’étendre aux êtres formés ou transformés par l'industrie humaine. La présente contribution examine les conditions nécessaires pour que soient reconnus ou accordés des droits tels que les droits de l'homme aux individus trans/posthumains.
‘The Biggest Charity You’ve Never Heard of’: Institutional Logics of Charity and the State in Public Fundraising in Scotland’s NHS.
Authors: STEWART ELLEN , DODWORTH KATHY 
Published: July 2021

AbstractThe boundaries between state and charitable activities within the NHS are set out in regulations but are also enacted, blurred, and contested through local practices. This article reports research on NHS Charities– charitable funds set up within NHS organizations to enhance statutory provision – in Scotland. We analysed financial accounts and conducted qualitative interviews with staff in 12 of the 14 NHS Charities in Scotland, where they are generally known as endowments. Our findings suggest that Scotland’s endowments are relatively wealthy in charitable terms, but that this wealth is unevenly distributed when population size and socio-economic deprivation are considered. We also identify two diverging organisational approaches to decisions, including those about appropriate and inappropriate fundraising. We argue that these approaches cohere with contrasting ‘state’ and ‘charitable’ institutional logics, which in turn imply different attitudes to potential inequalities, and to relationships with local publics.
Does coffee, tea and caffeine consumption reduce the risk of incident breast cancer? A systematic review and network meta-analysis
Authors: Wang Shu , Li Xiang , Yang Yue , Xie Jingping , Liu Mingyue , Zhang Ya , Zhang Yingshi , Zhao Qingchun 
Published: July 2021

AbstractObjective:We aimed to evaluate the association between coffee and/or tea consumption and breast cancer (BC) risk among premenopausal and postmenopausal women and to conduct a network meta-analysis.Design:Systematic review and network meta-analysis.Setting:We conducted a systematic review of electronic publications in the last 30 years to identify case–control studies or prospective cohort studies that evaluated the effects of coffee and tea intake.Results:Forty-five studies that included more than 3 323 288 participants were eligible for analysis. Network meta-analysis was performed to determine the effects of coffee and/or tea consumption on reducing BC risk in a dose-dependent manner and differences in coffee/tea type, menopause status, hormone receptor and the BMI in subgroup and meta-regression analyses. According to the first pairwise meta-analysis, low-dose coffee intake and high-dose tea intake may exhibit efficacy in preventing ER(estrogen receptor)− BC, particularly in postmenopausal women. Then, we performed another pairwise and network meta-analysis and determined that the recommended daily doses were 2–3 cups/d of coffee or ≥5 cups/d of tea, which contained a high concentration of caffeine, particularly in postmenopausal women.Conclusions:Coffee and tea consumption is not associated with a reduction in the overall BC risk in postmenopausal women and is associated with a potentially lower risk of ER− BC. And the highest recommended dose is 2–3 cups of coffee/d or ≥5 cups of tea/d. They are potentially useful dietary protectants for preventing BC.
COMPARISON OF KUMMER LOGARITHMIC TOPOLOGIES WITH CLASSICAL TOPOLOGIES
Authors: Zhao Heer 
Published: July 2021

AbstractWe compare the Kummer flat (resp., Kummer étale) cohomology with the flat (resp., étale) cohomology with coefficients in smooth commutative group schemes, finite flat group schemes, and Kato’s logarithmic multiplicative group. We are particularly interested in the case of algebraic tori in the Kummer flat topology. We also make some computations for certain special cases of the base log scheme.
Evaluation of Mean State in NCEP Climate Forecast System (Version 2) Simulation Using a Stochastic Multicloud Model Calibrated With DYNAMO RADAR Data
Authors: Roy Kumar , Mukhopadhyay Parthasarathi , Krishna R. P. M. , Khouider B. , Goswami B. B. 
Published: July 2021

AbstractStochastic parameterizations are continuously providing promising simulations of unresolved atmospheric processes for global climate models (GCMs). One of the stochastic multi‐cloud model (SMCM) features is to mimic the life cycle of the three most common cloud types (congestus, deep, and stratiform) in tropical convective systems. To better represent organized convection in the Climate Forecast System version 2 (CFSv2), the SMCM parameterization is adopted in CFSv2 (SMCM‐CTRL) in lieu of the pre‐existing revised simplified Arakawa–Schubert (RSAS) cumulus scheme and has shown essential improvements in different large‐scale features of tropical convection. But the sensitivity of the SMCM parameterization from the observations is yet to be ascertained. Radar data during the Dynamics of the Madden‐Julian Oscillation (DYNAMO) field campaign is used to tune the SMCM in the present manuscript. The DYNAMO radar observations have been used to calibrate the SMCM using a Bayesian inference procedure to generate key time scale parameters for the transition probabilities of the underlying Markov chains of the SMCM as implemented in CFS (hereafter SMCM‐DYNAMO). SMCM‐DYNAMO improves many aspects of the mean state climate compared to RSAS, and SMCM‐CTRL. Significant improvement is noted in the rainfall probability distribution function over the global tropics. The global distribution of different types of clouds, particularly low‐level clouds, is also improved. The convective and large‐scale rainfall simulations are investigated in detail.
Atmospheric Rivers Impacting Northern California Exhibit a Quasi‐Decadal Frequency
Authors: Stuivenvolt‐Allen Jacob , Wang Shih‐Yu Simon , Johnson Zachary , Chikamoto Yoshimitsu 
Published: July 2021

AbstractPeriods of water surplus and deficit in Northern California follow a pronounced quasi‐decadal cycle. This cycle is largely driven by the frequency of atmospheric rivers (ARs), affecting the region’s wet and dry periods. Our analyses demonstrate that the quasi‐decadal cycle of AR frequency relies on moisture transport associated with the position and intensity of the Aleutian Low. In observations, the Aleutian Low is shown to covary with tropical Pacific sea surface temperature anomalies. A modeling experiment, which incorporates ocean observations from the equatorial Pacific into the fully coupled climate model, provides support that the quasi‐decadal cycle of the Aleutian Low is forced by the tropical Pacific. Subsequently, the tropical Pacific modulates the wet season moisture transport toward California on decadal time scales, affecting AR frequency. These results provide metrics for improving interannual‐to‐decadal prediction of AR activity, which drives hydrological cycles in Northern California.
A New Hydrologic Sensitivity Framework for Unsteady‐State Responses to Climate Change and Its Application to Catchments With Croplands in Illinois
Authors: Han Peng‐Fei , Istanbulluoglu Erkan , Wan Li , Wang Xu‐Sheng 
Published: July 2021

AbstractClimate change has been concerned as a trigger of hydrologic changes around the world. Budyko framework was widely used in hydrologic sensitivity analyses on the steady‐state water balance. The unsteady‐state responses, for example the inter‐annual hydrologic sensitivity, were not well investigated, especially for catchments influenced by croplands as that exist in Illinois in the United States. We propose a new hydrologic sensitivity framework for the unsteady‐state condition, together with a new hydrological model, to investigate the impact of croplands on the hydrologic sensitivity. In addition to the Budyko‐type relationship between the annual evapotranspiration ratio (E/P) and the aridity index (Ep/P), this framework incorporates the empirical relationship between the annual storage change ratio (ΔS/P) and Ep/P into sensitivity coefficients. The required data of annual E/P and ΔS/P could be obtained from observation and hydrological models. In particular, the bcd‐αK model is newly developed from the existing bcd model in considering croplands in Illinois, which includes only five parameters while capturing major hydrological processes for catchments with croplands. Results show that the annual E/P, ΔS/P and Q/P in 12 studied catchments have significant linear relationships with Ep/P. The annual runoff is much more sensitive to the change in precipitation than to the change in potential evapotranspiration. The traditional steady‐state analysis overestimates the sensitivity of the evapotranspiration to the change in the precipitation for the unsteady‐state condition and underestimates the variability of sensitivity coefficients among catchments.
Jointly Calibrating Hydrologic Model Parameters and State Adjustments
Authors: Kim S. S. H. , Marshall L. A. , Hughes J. D. , Sharma A. , Vaze J. 
Published: July 2021

AbstractA method is presented to address model state uncertainty in hydrologic model simulation. This is achieved by introducing tuneable parameters that allow adjustments to the model states. Excessive dimensionality is avoided by introducing only a limited number of parameters that control the index (timing) and size of the state adjustments. The method is designed to compensate for issues with hydrologic model structures, particularly those relevant to the soil moisture state in a rainfall‐runoff model. In the context of water resource planning and management, errors in the model states have often been overlooked as an important source of uncertainty and have the potential to significantly degrade model simulations. A synthetic study shows that a classical parameter estimation approach will produce biased distributions when state errors exist, and that the proposed state and parameter uncertainty estimation (SPUE) can remove the bias in parameter estimates for improved model simulations. In a real case study, SPUE and the classical approach are implemented in 46 sites around Australia. The results show that hydrologic parameter distributions for a selected conceptual model can be significantly different when accounting for state uncertainty. This has large implications for scenario modeling since it puts into dispute how to determine appropriate parameters for such studies. SPUE outperforms the classical approach in a range of calibration and validation metrics, particularly for sites that contain zero flows. Future work involves testing SPUE with different hydrologic models and likelihood formulations, and enhancing rigor by explicitly accounting for observational data uncertainty.
Underground Traffic‐Induced Body Waves Used to Quantify Seismic Attenuation Properties of a Bimaterial Interface Nearby a Main Fault
Authors: Le Gonidec Y. , Kergosien B. , Wassermann J. , Jaeggi D. , Nussbaum C. 
Published: July 2021

AbstractUnderground traffic activities spread ground‐borne vibrations in a complex way. The present work focuses on 173 individual vehicles tracked as moving sources of vibrations in the Mont Terri rock laboratory, located 95 m away from a motorway tunnel. Two neighboring geophones record the vertical ground velocity of traffic‐induced events with peak particle velocities ranging in 0.15–0.35 m/s. A dynamic cross‐correlation of the waveforms is used to align the individual events for coherent and robust analysis. A root mean square (rms) method allows identifying the main feature, centered at the Main Fault, and an unexpected feature located about 140 m apart. The dominant seismic frequencies are 15 and 10 Hz, respectively. The vehicle speeds (70–90 km/h), estimated from the time‐delay between the two features, and the seismic velocity (800–2,300 m/s), assessed from a simple kinematic model, are used to convert time to position along the tunnel, allowing modeling the local rms with the Bornitz's equation. The resolved frequency‐independent attenuation coefficients are 2.61 s/km in the Opalinus Clay including the gallery network, and 1.23 s/km in the Limestone, a contrast of elastic properties that defines a bimaterial interface. A particle motion analysis highlights body waves, with dominant vertically polarized shear waves above the Main Fault. The origin of the unexpected feature is discussed in terms of site effects and seismic propagation in a heterogeneous fracture network. Traffic‐induced events can be used as reproducible, low‐frequency, and non‐destructive sources with potential interest in long‐term monitoring at the scale of an underground gallery.
Dual targeting of the DNA damage response pathway and BCL-2 in diffuse large B-cell lymphoma
Authors: Rossi Alessandra , Orecchioni Stefania , Falvo Paolo , Tabanelli Valentina , Baiardi Elena , Agostinelli Claudio , Melle Federica , Motta Giovanna , Calleri Angelica , Fiori Stefano , Corsini Chiara , Casadei Beatrice , Mazzara Saveria , Vitolo Umberto , Bertolini Francesco , Zinzani Pier Luigi , Alcalay Myriam , Pelicci Pier Giuseppe , Pileri Stefano , Tarella Corrado , Derenzini Enrico 
Published: July 2021

AbstractStandard chemotherapies for diffuse large B-cell lymphoma (DLBCL), based on the induction of exogenous DNA damage and oxidative stress, are often less effective in the presence of increased MYC and BCL-2 levels, especially in the case of double hit (DH) lymphomas harboring rearrangements of the MYC and BCL-2 oncogenes, which enrich for a patient’s population characterized by refractoriness to anthracycline-based chemotherapy. Here we hypothesized that adaptive mechanisms to MYC-induced replicative and oxidative stress, consisting in DNA damage response (DDR) activation and BCL-2 overexpression, could represent the biologic basis of the poor prognosis and chemoresistance observed in MYC/BCL-2-positive lymphoma. We first integrated targeted gene expression profiling (T-GEP), fluorescence in situ hybridization (FISH) analysis, and characterization of replicative and oxidative stress biomarkers in two independent DLBCL cohorts. The presence of oxidative DNA damage biomarkers identified a poor prognosis double expresser (DE)-DLBCL subset, characterized by relatively higher BCL-2 gene expression levels and enrichment for DH lymphomas. Based on these findings, we tested therapeutic strategies based on combined DDR and BCL-2 inhibition, confirming efficacy and synergistic interactions in in vitro and in vivo DH-DLBCL models. These data provide the rationale for precision-therapy strategies based on combined DDR and BCL-2 inhibition in DH or DE-DLBCL.
Molecular insights into the human ABCB6 transporter
Authors: Song Guangyuan , Zhang Sensen , Tian Mengqi , Zhang Laixing , Guo Runyu , Zhuo Wei , Yang Maojun 
Published: July 2021

AbstractABCB6 plays a crucial role in energy-dependent porphyrin transport, drug resistance, toxic metal resistance, porphyrin biosynthesis, protection against stress, and encoding a blood group system Langereis antigen. However, the mechanism underlying porphyrin transport is still unclear. Here, we determined the cryo-electron microscopy (cryo-EM) structures of nanodisc-reconstituted human ABCB6 trapped in an apo-state and an ATP-bound state at resolutions of 3.6 and 3.5 Å, respectively. Our structures reveal a unique loop in the transmembrane domain (TMD) of ABCB6, which divides the TMD into two cavities. It restrains the access of substrates in the inward-facing state and is removed by ATP-driven conformational change. No ligand cavities were observed in the nucleotide-bound state, indicating a state following substrate release but prior to ATP hydrolysis. Structural analyses and functional characterizations suggest an “ATP-switch” model and further reveal the conformational changes of the substrate-binding pockets triggered by the ATP-driven regulation.