bluuebunny/crossref_metadata_2025_split huggingface dataset:
The indigenous meaning of dysmenorrhea: using modified photovoice to document perspectives of traditional health practitioners (THPs) and indigenous knowledge holders (IKHs)
Authors: Rasweswe Melitah Molatelo , Peu Mmapheko Doriccah , Mulaudzi Fhumulani Mavis 
Published: July 2021

Background: Globally, health understanding and beliefs vary across sub-cultural groups, depending on geographical location. Increasingly, various parts of the world recognize these perspectives to offer culturally sensitive healthcare services at primary level. Understanding the indigenous perspectives of dysmenorrhea meaning from the custodians of knowledge holders may add to the value of literature that may be used to advocate humanized culturally sensitive healthcare. This article aimed to explore and describe the perspectives regarding the meaning of indigenous dysmenorrhea among Batlokwa traditional health practitioners (THPs) and indigenous knowledge holders (IKHs). Methods: A qualitative, explorative study with a modified photovoice design, which included photographs, interviews and lekgotla discussion was employed to engage THPs and IKHs residing in Botlokwa Limpopo province, South Africa. Initially, a purposive sampling technique was used to select the participants, followed by snowball sampling. The participants themselves analyzed the photographs and described their meaning during individual interview using the acronym “PHOTO”. The researchers employed thematic analysis of interviews and Lekgotla discussion, in which themes were identified, formulated and analyzed from the codified data set. Results: In total, eight women participated in the photovoice study. The findings showed that indigenous understanding of dysmenorrhea stems from the African belief about health and illness with special emphasis on importance of holistic meaning. To the THPs and IKHs dysmenorrhea was a broad and integrated trend of a normal or abnormal process of illness that occurs periodically during menstruation. Conclusions: The THP’s and IKH’s indigenous meaning of dysmenorrhea reflects physical, mental, emotional, social, environmental, political and economic dimensions. Therefore, dysmenorrhea should be understood from a holistic approach. With appropriate partnerships and processes in place, this knowledge may be well represented in dominant healthcare systems and health research.
Case Report: Cerebral venous thrombosis revealing celiac disease
Authors: Wiem Romdhane , Sondess Arfa , Jihene Chelly , Olfa Jomaa , Sonia Hammami , Karima Hmida , Fatma El Arbi , Olfa Berriche 
Published: July 2021

Celiac disease (CD) is an autoimmune enteropathy resulting from intolerance of an individual genetically predisposed to gluten. It has a large clinical polymorphism ranging from a classic digestive clinical presentation due to the malabsorption syndrome to extra-intestinal symptoms. Among the hematologic abnormalities, venous thromboembolic disease (VTE) has been reported, and they are most often located in the abdomen or lower limbs, but the cerebral localization was exceptionally described. We report a case of CD revealed by cerebral thrombophlebitis. A 44-year-old patient with no medical history and no drug intake, presented with hemiplegia followed by a status epilepticus in a context of apyrexia, initially hospitalized in intensive care. Magnetic imaging resonance displayed a cerebral venous thrombosis of the sigmoid sinus requiring anticoagulant treatment, then transferred to our department for the etiological investigation. On questioning, the patient reported chronic diarrhea and weight loss with no other associated symptoms. The examination revealed an underweight patient with pale conjunctiva, improvement of her deficit symptoms, and no other abnormalities. Laboratory tests noted biological signs of malabsorption. The thrombophilia assessment revealed a protein C deficiency with a slight increase in anticardiolipin antibodies and anti-Beta 2 glycoprotein 1 antibodies. Immunological tests noted positives anti-transglutaminase and IgA anti-endomysium antibodies. Duodenal biopsy demonstrated villous atrophy. After ruling out the other causes of VTE, the diagnosis of cerebral venous thrombosis secondary to CD was retained. Early diagnosis and treatment of CD improves the quality-of-life for patients and may spare them various long-term or even fatal complications.
Impact of AYUSH interventions on COVID-19: a protocol for a living systematic review and meta-analysis
Authors: Thakar Anup , Panara Kalpesh , Goyal Mandip , Kumari Ritu , Sungchol Kim 
Published: July 2021

Background: The coronavirus disease 2019 (COVID-19) pandemic has created a great burden on governments and the medical fraternity globally. Many clinical studies from the Indian system of Traditional Medicines [Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homoeopathy (AYUSH)] have been carried out to find appropriate solutions. Through a living systematic review and meta-analysis, this study aims to determine the effectiveness of the Traditional System of Indian Medicine (AYUSH system) in lowering the incidence, duration, and severity of COVID-19. Methods: We will search the following databases: Pubmed; the Cochrane central register of controlled trials (CENTRAL); the Clinical Trials Registry - India (CTRI); Digital Helpline for Ayurveda Research Articles (DHARA): AYUSH research portal; and World Health Organization (WHO) COVID-19 database. Clinical improvement, WHO ordinal scale, viral clearance, incidences of COVID-19 infection, and mortality will be considered as primary outcomes. Secondary outcomes will be use of O2 therapy or mechanical ventilator, admission to high dependency unit or emergency unit, duration of hospitalization, the time to symptom resolution, and adverse events. Two authors will independently search the articles, extract the data and disagreements will be resolved by the involvement of a third reviewer. Data will be synthesized, and the risk of bias will be assessed with RevMan 5.4 tool. Certainty of evidence will be assessed through the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) tool. The review will be updated bi-monthly with two updates. Conclusion: This living systematic review will be the first to address AYUSH interventions in COVID-19, synthesizing the full spectrum of Indian Traditional System of Medicine against COVID-19. It will facilitate professionals, guideline developers, and authorities with up to date synthesis on interventions periodically to make health-care decisions on AYUSH therapies in the management of COVID-19.
Design analysis and test verification of a rigid–flexible, dual-mode coupling support structure for space-based rectangular curved prisms
Authors: Jia Xin-Yin , Wang Fei-Cheng , Li Li-Bo , Zhang Zhao-Hui , Liu Jia , Hu Bing-Liang 
Published: July 2021

In view of the functional requirements of high reliability and stability support of optical components of space remote sensors, a rigid–flexible, dual-mode coupling support structure for space-based rectangular curved prisms (SRCPs) was designed. In-depth studies of the support principle and engineering realization of the SRCPs and optimization of the flexible adhesive structure were performed. Static and dynamic simulations were conducted on the mirror subassembly by means of finite element analysis, and test verification was also performed. The tests revealed that the surface shape error of the mirror subassembly after mechanical testing was

0.021

λ

, the displacement of the mirror body was 0.008 mm, the inclination angle was

∼

0.8

′
′

, the mass of the mirror subassembly was 4.79 kg, the fundamental frequency was 283 Hz, and the maximum amplification of the total rms acceleration was 4.37. All indexes were superior to those of the design requirements. On this basis, bonding tests and mechanical tests of a rectangular curved prism reflector, a rectangular curved prism, and a rectangular plane reflector employing this proposed support structure were continued. The test results verified the reliability, stability, and universal applicability of the proposed rigid–flexible, dual-mode peripheral bonding support structure.
Vision vibration measurement based on coded illumination in a single frame
Authors: Zhang Yuanjun , Qu Xinghua , Liang Xiaobo , Xu Lianyin , Wang Jindong , Zhang Fumin 
Published: July 2021

A vision-based mechanical vibration measurement method is presented and verified by experiments in this paper. The coded illumination is projected on the objects by a digital light processing projector with a digital micromirror device in it. The projection patterns are designed to be concentric. In one integration time of the camera, the projector is exposed several times, which embeds temporal information in the images. A single frame can be divided into subframes by separating the coded concentric patterns. The centroids of the coded concentric patterns are fitted, and the centroids are treated as virtual feature points with vibration information. The acquisition devices are common low-speed cameras, and they record the vibration whose frequency exceeds the camera frame rate. The temporal resolution is increased by 10 times, corresponding to the 400 Hz sampling frequency in the experiment. We can measure the vibration of multiple points with different sampling frequencies. The frequency measurement accuracy is in the subhertz level in low-frequency measurement, relative error is always slightly greater than 0.01 in high-frequency measurement, and the amplitude resolution is 130 µm.
Distortion corrected tomographic near-eye displays using light field optimization
Authors: Lee Siwoo , Lee Seungjae , Kim Dongyeon , Lee Byoungho 
Published: July 2021

Several multifocal displays have been proposed to provide accurate accommodation cues. However, multifocal displays have an undesirable feature, which is especially emphasized in near-eye displays configuration, that the field of views (FOVs) of the virtual planes change over depth. We demonstrate that this change in FOV causes image distortions, which reduces overall image quality, and depth perception error due to the variation of image sizes according to depths. Here, we introduce a light field optimization technique to compensate for magnification variations among the focal planes. Our approach alleviates image distortions, especially noticeable in the contents with large depth discontinuity, and reconstructs the image size to precise depths, while maintaining a specific tolerance length for the target eye relief. To verify the feasibility of the algorithm, we employ this optimization method for the tomographic near-eye display system to acquire the optimal image and backlight sequences for a volumetric scene. In general, we confirm that the structural similarity index measure of reconstructed images against ground truth increases by 20% when the eye relief is 15 mm, and the accommodation cue is appropriately stimulated at the target depth with our proposed method.
Multidimensional analysis of immune responses identified biomarkers of recent Mycobacterium tuberculosis infection
Authors: Lloyd Tessa , Steigler Pia , Mpande Cheleka A. M. , Rozot Virginie , Mosito Boitumelo , Schreuder Constance , Reid Timothy D. , Hatherill Mark , Scriba Thomas J. , Little Francesca , Nemes Elisa ,   the ACS Study Team
Published: July 2021

The risk of tuberculosis (TB) disease is higher in individuals with recentMycobacterium tuberculosis(M.tb) infection compared to individuals with more remote, established infection. We aimed to define blood-based biomarkers to distinguish between recent and remote infection, which would allow targeting of recently infected individuals for preventive TB treatment. We hypothesized that integration of multiple immune measurements would outperform the diagnostic performance of a single biomarker. Analysis was performed on different components of the immune system, including adaptive and innate responses to mycobacteria, measured on recently and remotelyM.tbinfected adolescents. The datasets were standardized using variance stabilizing scaling and missing values were imputed using a multiple factor analysis-based approach. For data integration, we compared the performance of a Multiple Tuning Parameter Elastic Net (MTP-EN) to a standard EN model, which was built to the individual adaptive and innate datasets. Biomarkers with non-zero coefficients from the optimal single data EN models were then isolated to build logistic regression models. A decision tree and random forest model were used for statistical confirmation. We found no difference in the predictive performances of the optimal MTP-EN model and the EN model [average area under the receiver operating curve (AUROC) = 0.93]. EN models built to the integrated dataset and the adaptive dataset yielded identically high AUROC values (average AUROC = 0.91), while the innate data EN model performed poorly (average AUROC = 0.62). Results also indicated that integration of adaptive and innate biomarkers did not outperform the adaptive biomarkers alone (Likelihood Ratio Testχ2= 6.09, p = 0.808). From a total of 193 variables, the level of HLA-DR on ESAT6/CFP10-specific Th1 cytokine-expressing CD4 cells was the strongest biomarker for recentM.tbinfection. The discriminatory ability of this variable was confirmed in both tree-based models.A single biomarker measuringM.tb-specific T cell activation yielded excellent diagnostic potential to distinguish between recent and remoteM.tbinfection.
Effect of sanitation improvements on soil-transmitted helminth eggs in courtyard soil from rural Bangladesh: Evidence from a cluster-randomized controlled trial
Authors: Kwong Laura H. , Sen Debashis , Islam Sharmin , Shahriar Sunny , Benjamin-Chung Jade , Arnold Benjamin F. , Hubbard Alan , Parvez Sarker Masud , Islam Mahfuza , Unicomb Leanne , Rahman Md. Mahbubur , Nelson Kara , Colford John M. , Luby Stephen P. , Ercumen Ayse 
Published: July 2021

Improved sanitation has been hypothesized to reduce soil-transmitted helminth (STH) infections by reducing the prevalence and concentration of STH eggs/larvae in soil. We evaluated the effect of a randomized sanitation program (providing households with an improved dual-pit latrine, tools for child/animal feces management, and behavioral messaging) on reducing the prevalence and concentration of STH eggs in soil from household courtyards. We collected soil samples from 1405 households enrolled in the sanitation intervention (n = 419) and control (n = 914) groups of a cluster-randomized controlled trial (WASH Benefits) in rural Bangladesh approximately 2 years after the initiation of the interventions. We analyzed samples for Ascaris lumbricoides, Trichuris trichiura, and hookworm eggs by microscopy. We estimated prevalence ratios (PR) and egg count ratio (ECR) to compare the prevalence of STH eggs and arithmetic and geometric mean egg counts for STH eggs per gram of soil in the sanitation and control arms. Among intervention households, latrines achieved high and sustained user uptake by adults while child open defecation remained common and most households did not dispose of child feces hygienically. In courtyard soil from control households, the prevalence of any STH eggs was 75.7% and the prevalence of any larvated STH eggs was 67.3%. A. lumbricoides was detected in 63.0% of control samples and T. trichiura in 55.7% of control samples; hookworm was not detected in any sample. In the control arm, the arithmetic mean egg count for any STH was 3.96 eggs/dry gram, while the geometric mean was 1.58 eggs/dry gram. There was no difference between the intervention and control groups in the prevalence of any STH eggs (PR = 0.98 (95% CI: 0.91, 1.05)) or mean egg counts (ECR = 0.08 (95% CI: -0.10, 0.26) for geometric mean and 0.07 (95% CI: -0.22, 0.37) for arithmetic mean). Adjusted models gave similar results. A compound-level sanitation intervention that provided improved latrines and tools for disposal of child and animal feces did not have an impact on STH eggs in soil. In order to effectively reduce the prevalence and concentration of STH eggs in the environment, sustained, widespread use of sanitation strategies to isolate and hygienically dispose of child and animal feces may need to complement traditional strategies for containment of adult human feces.
Trial Registration: NCT01590095.
Associations between early postoperative pain outcome measures and late functional outcomes in patients after knee arthroplasty
Authors: Dubljanin Raspopović Emilija , Meissner Winfried , Zaslansky Ruth , Kadija Marko , Tomanović Vujadinović Sanja , Tulić Goran 
Published: July 2021

Introduction/Aim
Early rehabilitation, return to daily life activities and function are the ultimate goals of perioperative care. It is unclear which pain-related patient-reported outcome measures (PROM) mirror treatment effects or are related with early and late functional outcomes.

Methods
We examined associations between two approaches of pain management (scheduled vs ‘on demand’) and PROMs on post-operative days one and five (POD1, 5) with function on POD5 and 3 months after surgery in patients undergoing Total Knee Arthroplasty (TKA) in a single centre. The scheduled pain management consisted of pain assessment and routine administration of non-opioid drugs, and a weak opioid based on severity of pain reported by patients. The ‘on demand’ group received non-opioids and/or a weak opioid only when asking ‘on demand’ for analgesics.

Results
On POD1, patients in the scheduled treatment group reported reduced severity of worst pain, less interference of pain with activities in-bed and sleep, and a higher proportion got out of bed. On POD5, these patients reported as well significantly less worst pain, spent significantly less time in severe pain, experienced less interference of pain with activities in bed, and felt less helpless. Furthermore, tests of function, extension and flexion ranges, Barthel index and 6 minutes walking test on POD5, and the Knee Injury and Osteoarthritis Outcome Score (KOOS) 3 months later were significantly better in the scheduled treatment group compared to the ‘on demand’ treatment group. Pain related PROMs assessed at POD1 and especially at POD5 are associated with better knee range of motion, better performance in activities of daily living, and faster gait speed, as well as less pain, better performance in activities of daily living, as well as higher knee-related quality of life 3 months postoperatively.

Conclusions
Our study demonstrates that severe postoperative pain after TKA might have long lasting consequences, and even small improvements in treatment, although being far from optimal, are accompanied by improved outcomes.
Developing a model for estimating the activity of colonic microbes after intestinal surgeries
Authors: Marcus Andrew , Davis Taylor L. , Rittmann Bruce E. , DiBaise John K. , Carnero Elvis A. , Corbin Karen , Smith Steven R. , Krajmalnik-Brown Rosa 
Published: July 2021

Background
The large intestine provides a compensatory role in energy recovery when surgical interventions such as extensive small intestinal resections or bypass operations lower the efficiency of nutrient absorption in the upper gastrointestinal (GI) tract. While microorganisms in the colon are known to play vital roles in recovering energy, their contributions remain to be qualified and quantified in the small intestine resection.

Objective
We develop a mathematical model that links nutrient absorption in the upper and lower GI tract in two steps.

Methods
First, we describe the effects of small intestine resection on the ileocecal output (ICO), which enters the colon and provides food for microbes. Second, we describe energy recovered by the colon’s microorganisms via short-chain fatty acid (SCFA) production. We obtain model parameters by performing a least-squares regression analysis on clinical data for subjects with normal physiology and those who had undergone small intestine resection.

Results
For subjects with their intestines intact, our model provided a metabolizable energy value that aligns well with the traditional Atwater coefficients. With removal of the small intestine, physiological absorption became less efficient, and the metabolizable energy decreased. In parallel, the inefficiencies in physiological absorption by the small intestine are partly compensated by production of short-chain fatty acids (SCFA) from proteins and carbohydrates by microorganisms in the colon. The colon recovered more than half of the gross energy intake when the entire small intestine was removed. Meanwhile, the quality of energy absorbed changed, because microbe-derived SCFAs, not the original components of food, become the dominant form of absorbed energy.

Conclusion
The mathematical model developed here provides an important framework for describing the effect of clinical interventions on the colon’s microorganisms.
Cost-effectiveness of procedure-less intragastric balloon therapy as substitute or complement to bariatric surgery
Authors: Mital Shweta , Nguyen Hai V. 
Published: July 2021

BackgroundProcedure-less intragastric balloon (PIGB) eliminates costs and risks of endoscopic placement/removal and involves lower risk of serious complications compared with bariatric surgery, albeit with lower weight loss. Given the vast unmet need for obesity treatment, an important question is whether PIGB treatment is cost-effective—either stand-alone or as a bridge to bariatric surgery.MethodsWe developed a microsimulation model to compare the costs and effectiveness of six treatment strategies: PIGB, gastric bypass or sleeve gastrectomy as stand-alone treatments, PIGB as a bridge to gastric bypass or sleeve gastrectomy, and no treatment.ResultsPIGB as a bridge to bariatric surgery is less costly and more effective than bariatric surgery alone as it helps to achieve a lower post-operative BMI. Of the six strategies, PIGB as a bridge to sleeve gastrectomy is the most cost-effective with an ICER of $3,781 per QALY gained. While PIGB alone is not cost-effective compared with bariatric surgery, it is cost-effective compared with no treatment with an ICER of $21,711 per QALY.ConclusionsPIGB can yield cost savings and improve health outcomes if used as a bridge to bariatric surgery and is cost-effective as a stand-alone treatment for patients lacking access or unwilling to undergo surgery.