bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of advanced-stage ovarian cancer including combination of intra-abdominal chemotherapy
Authors: Saevets V. V. , Privalov A. V. , Vazhenin A. V. , Semenov Y. A. , Shmidt A. V. 
Published: July 2021

Introduction.Ovarian cancer is the leading cause of death from gynecological malignancies: the one-year relative survival rate with stages 3 and 4 of the disease is 20%. The results of treatment remain unsatisfactory, which dictates the need to find new methods of treatment. The aim of the study was to evaluate the effectiveness of the use of HIIH (hyperthermic intraperitoneal intraoperative chemoperfusion, HIPEC) in patients with the diagnosis of: ovarian cancer IIIA-From the stage of the disease.Materials and methods.117 cases of stage IIIA-C ovarian cancer treated at the Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine from January 2014 to March 2021 were retrospectively studied. All patients underwent 3 cycles of neoadjuvant chemotherapy (NAPHT) according to the paclitaxel+carboplatin (PCb) scheme, followed by surgical treatment to the extent of maximum cytoreductive surgery. Two study groups were formed: 1 — cases with GIIH (N=57), 2-without GIIH (N=60). On the 14-16 day after the operation, all patients underwent 3 cycles of adjuvant chemotherapy according to the PCb scheme.Results.A significant increase in overall survival was found in the first group of patients with HIPEC. This technique allows to increase the survival rate of patients for 14 months at stage IIIA-B (p<0.05). At stage IIIC, there was no statistically significant difference in the survival rate of patients. There was a tendency to increase the survival rate by 5 months (p>0.05), which is associated with the pronounced prevalence of the tumor process and the technical impossibility of removing the tumor. Discussion.The concentration of drugs in the abdominal cavity and in the blood plasma significantly differs due to the functioning of the peritoneal-plasma barrier, which leads to a lower toxicity in comparison with systemic chemotherapy, and therefore allows you to give a large dose of the drug with fewer adverse events, and the fact of hyperthermia (42°C) has a positive effect on the effectiveness of intraperitoneal chemotherapy. To date, this method has not been included in the clinical recommendations on the territory of the Russian Federation, but data from foreign literature, including randomized trials, have shown the high effectiveness of this method.Conclusion.The results obtained in the course of our study demonstrate the effectiveness of this technique, in the form of an increase in overall and relapse-free survival with acceptable toxicity.
Features of the lymphocytic microenvironment in metastatic uveal melanoma
Authors: Shamanova A. Y. , Kazachkov E. L. , Panova I. Е. , Vazhenin A. V. , Shamaeva Т. N. , Alymov Е. A. 
Published: July 2021

Introduction.Uveal melanoma is a malignant neoplasm of the vascular tract of the eye. Prevention of metastasis of this tumor is one of the main tasks in order to increase the rates of relapse-free survival of patients. Despite the pronounced immunosuppressive activity of uveal melanoma cells, its lymphocytic microenvironment exerts its antitumor effect.Aim of the study.Compare the lymphocytic microenvironment of primary uveal melanomas and distant metastases (to the liver).Мaterials and methods.The tissue material of choroid melanoma after enucleation and the material of tumor metastases for the period 2013-2018 were studied. An immunohistochemical study was performed using CD8, CD4, and CD56 markers for the qualitative and quantitative assessment of lymphocytes in the tumor stroma.Results.Differences were found in the lymphocytic infiltration of the uveal melanoma stroma and its distant metastases. A statistically significantly greater representation of CD4, CD8-lymphocytes and CD56 cells in tumor metastases than in primary melanoma tissue samples, with CD4-lymphocytes predominant. A direct high-strength correlation was registered between the number of CD4-lymphocytes and CD8-lymphocytes.Discussion.Malignant cells actively modify their cellular and stromal-vascular environment, ensuring their active growth and reproduction. The question of the immune reactivity of the surrounding cells in relation to uveal melanoma remains debatable. According to our data, which is consistent with a number of other studies, uveal melanoma cells do not completely evade the body's immune response. Thus, the determination of possible points of antitumor exposure can be based on a detailed study of the microenvironment of uveal melanoma.Conclusions.The pronounced lymphocytic infiltrate found in uveal melanoma metastases in comparison with the primary tumor indicates an active immune response of the body to the tumor. These results of our study confirm the importance of further studying the immune-mediated antitumor effect on uveal melanoma and the need to investigate possible approaches to immunotherapy.
Difficulties of radiological diagnosis оf small breast cancers
Authors: Leikht Т. N. , Bratnikova G. I. , Gomina Р. S. , Kosolapova N. S. , Tihaya К. A. , Kotova L. D. , Samosyuk N. А. , Repyanskaya I. А. , Utin К. G. 
Published: July 2021

Introduction. Breast cancer in the structure of malignancies in women takes the 1st place. There has been an annual increase in morbidity, including due to improvements in diagnostic interventions and screening. Mammography and ultrasound of the breasts is mandatory when diagnosing breast cancer. The difficulties of diagnosis are revealed in small tumors.Methods. Breast ultrasounds were performed on the ultrasound machines of the expert class TOSHIBA APLIO 500, PHILIPS EPIQ 5 and PHILIPS EPIQ 7. Mammography and tomosynthesis were performed on mammogram MAMMOMAT INSPITATION PRIME. Core-biopsia under ultrasound control was carried out on the Logiq9 ultrasound scanner. Eighty women were selected with suspected cancer after breast core-biopsy with the category BI-RADS 3, 4 and 5. The size of the node according to ultrasound data was 6-10 mm.Results. According to core-biopsia has been identified cancer, histologically and immunohystochemically confirmed in 50 cases. In 30 women benign tumors were identified. The most informative mammograms of breast cancer were high tumor density, ray of radiibility and local deformity of soft tissues. Among the characteristic ultrasonic signs of the cancer more often noted vertical orientation, reduced echogenicity, uneven contour, other signs were not so character for the cancer.Conclusion. You can't focus on a separate sign of education! Only a combination of traits, different diagnostic methods contribute to the correct diagnosis.
L-type amino acid transporter 1 inhibitor suppresses murine Th2 cell-mediated bronchial hyperresponsiveness independently of eosinophil accumulation
Authors: Ito Daiki , Miura Kento , Saeki Mayumi , Yamasaki Norimasa , Ogata Sawako , Koyama Teidai , Hiroi Takachika , Mori Akio , Endou Hitoshi , Hayashi Keitaro , Kaminuma Osamu 
Published: July 2021

Background
The activation of Th2 cells that play a pivotal role in the development of allergic eosinophilic inflammation is regulated by an L-type amino acid transporter (LAT) 1. However, the contribution of LAT1 to the pathogenesis of Th2 cell-mediated airway inflammation has not been investigated.

Objective
In this study, we investigated the effect of a LAT1 inhibitor, JPH203, on Th2 cell-mediated airway eosinophilic inflammation.

Methods
BALB/c mice were transferred with ovalbumin (OVA)-specific Th2 cell and challenged by corresponding allergen with or without administration of JPH203. Then, the infiltration of inflammatory cells including eosinophils and allergen-specific Th2 cells in the lungs and bronchial hyperresponsiveness (BHR) was assessed.

Results
Inflammatory responses in the lungs with massive accumulation of eosinophils and BHR were induced in Th2 cell-transferred mice upon challenge with OVA. The treatment with JPH203 significantly suppressed the allergen-induced BHR but not eosinophil infiltration. The infused Th2 cells were also accumulated in the lungs upon allergen challenge, though the response was not affected by JPH203 treatment.

Conclusion
JPH203 suppressed Th2 cell-mediated BHR through the mechanisms independently of the lung accumulation of eosinophils and Th2 cells.
Research Supporting Health Policy Development: Contextualizing Evidence for People-Centred Care in Low and Middle Income Countries
Authors: Rajan Dheepa 
Published: July 2021

The three areas of research, policy, and practice seem to work and interact within silos, or independent niches. Especially for the complex task of reorienting health care and indeed, a health system, towards people-centredness, these niches at both global and country level must be broken down. Since health policy-making is complex and non-linear, context is crucial for making research for health policies and implementation of health policies (practice) relevant. The real measure of success is whether the evidence-informed policy has worked and produced results at ground level. When context is so important, however, evidence (research) is only one piece of the puzzle. Stakeholder’s views, or simply put, their opinion, is just as decisive. This paper documents some promising examples in research and practice of bringing together evidence and stakeholder opinion, particularly highlighting a case study on Brazil as well as WHO tools for communities of practice.
The Protection of the Person is Central in CIOMS International Ethical Guidelines
Authors: Vallotton Michel , Fluss Sian , Sjolin Forsberg Gian 
Published: July 2021

In this brief article the authors report on the objectives of this nongovernmental organization and, most particularly, on the protection of the person in its International Ethical Guidelines for the fields of clinical trials and epidemiological studies. They emphasize the terminology used to describe the subjects or the populations involved in these studies. They discuss the possibility and nature of harm to persons involved in such studies, and justify the requirement for informed consent also for the persons involved in epidemiological studies. Finally, they consider the roles of such trials and studies as the basis for evidence-based medicine, including cases when their results are pooled in meta-analysis. This methodology is the subject of examination by a CIOMS Working Group of problems concerning identification and selection criteria, analysis and interpretation of results (including unpublished results), and storage of data.
Professional health education and person centered medicine
Authors: Mezzich Juan E , Braš Marijana , Dorđević Veljko , Appleyard James 
Published: July 2021

Health professional education and training is a major concern and activity in the field of medicine. Thus, not surprisingly, a person- and people-centered approach to health professional education has been a continuous topic in programmatic international efforts aimed at placing the whole person at the center of medicine and health. This has been certainly the case in the endeavors of the International College of Person Centered Medicine (ICPCM) through events such as its Geneva Conferences and International Congresses and its publications, particularly the International Journal of Person Centered Medicine. Further reflecting the ICPCM’s educational priorities have been institutional collaboration with the educational units of the World Health Organization, the consistent engagement of the World Federation for Medical Education and the International Association of Medical Colleges, and the increasing collaboration with distinguished academic institutions around the world. The First International Congress of the International College of Person Centered Medicine in Zagreb had as main theme Whole Person Health Education and Training. This event and its proceedings are highlighted in this editorial, which then briefly introduces the papers included in the present issue of the Journal.
Integration as a Key Strategy for Achieving Person- and People-Centered Care
Authors: Mezzich Juan E , Appleyard James 
Published: July 2021

The fundamental purpose of Person Centered Medicine (PCM) (and by extension of Person- and People-centered Care), is to promote the health and well-being of the totality of the person. Here the person is the central concept, which should be understood in a contextualized manner. This is illustrated by Ortega y Gasset aphorism "I am I and my circumstance, and if do not care for it I do not care for myself". In the discussion of what is central and what is instrumental in PCM, the eminent Indian scholar Shridhar Sharma (personal communication, 2012) has cogently stated that in medicine science is essential and humanism is the essence of medicine. It can be argued that the instrumental role of science could be shared by other important concepts and activities, such as integration, with similar functional roles vis-a-vis person- and people-centered care. Thus, when examining the World Health Organization's emerging six-year work plan seeking as a major objective person-centered integrated care, one could understand people-centered as the soul or essence and integration as a key methodology or strategy.
2014 Geneva Declaration on Person- and People-centered Integrated Health Care for All
Authors: Mezzich Juan 
Published: July 2021

We, participants in the 7th Geneva Conference on Person-centered Medicine, call on everyone to join together to promote person-centered and people-centered health care in order to improve health for all in ways that are equitable, sustainable, and cost-effective. Equity and integration in person-centered health care are crucial foundations for targeting opportunities for effective action. The International College of Person-Centered Medicine (ICPCM) adheres to the new perspectives on universal health care endorsed by the World Health Assembly since 2009 and reads with interest the 2013 Lancet Commission Report on “Global Health 2035: World converging within a generation”, both of which outline objectives, research, and strategies for developing Person- and People-centered Integrated Care (PPCIC) for all people
Nursing Perspectives on Person- and People-Centered Integrated Care for All
Authors: Kusano Yukiko 
Published: July 2021

Person-centeredness resides at the heart of nursing and nurses also place people at the centre of their activities to achieve a healthier society. The commitment of the International Council of Nurses (ICN) to deliver person- and people-centered care is evident in the ICN Code of Ethics for Nurses [1], ICN policy papers and is translated into various guidelines, programmes and research. Person- and people-centered healthcare requires not only commitment of individual nurses and other healthcare workers but also changes in healthcare systems including service delivery systems and other structures. It is necessary to take a whole government approach where person- and people-centered healthcare is considered by all ministries including non-health sectors. Active involvement of care recipients, nurses and other healthcare professionals in healthcare design and decision making is essential to achieve person- and people-centered healthcare.
Multimorbidity in Mentally Ill People: The Need for a Person-centered Integrated Approach
Authors: Millar Helen , Abou-Saleh Mohammed T 
Published: July 2021

The need for person-centered integrated care is particularly compelling for people who experience multimorbidity. The concept of multimorbidity has attracted increasing interest in the past decade with the recognition of multiple burdens of disease and their escalating costs for the individual and the community. It is evident in clinical practice that multimorbidity has become the norm rather than the exception, occurring in an increasingly younger population particularly in areas of socioeconomic deprivation and in low income countries. It is now well established that the mentally ill have a markedly reduced life expectancy due to predominantly cardiovascular and metabolic diseases. The combination of a chronic medical condition and a mental health problem presents specific complex challenges for the single disease model of care which continues to prevail as the current delivery system in which health care professionals are trained and operate. The growing evidence and experience for adopting an integrated collaborative person-centered approach demonstrates the need for a more effective model of care which is individualised, and focused on patient engagement to prevent disease and manage multiple conditions systematically. Given the limited resources in our current health care systems, this approach requires innovation and redesign of the system to provide comprehensive person-centered care encompassing early detection, co-ordinated multidisciplinary working across specialities as well as between primary and secondary care with easy access to basic healthy lifestyle care programs.
Persons Caring For Persons: A Public Health Policy Architecturally Presented
Authors: Carbone-Campoverde Fernando 
Published: July 2021

Background: In 2001 a number of limitations and inconsistencies were noted in the Peruvian national health system. In addition to long-standing structural issues, challenges emerged related to social determinants of health as well as health workers’ attitudes and skills. Objectives: The purpose of this paper is to describe some of the national health policy changes that the Ministry of Health of Peru considered necessary in 2002 to address the prevailing challenges and the particular implementation of such policies. Methods: The formulation of the desired national health policy changes were based on critical readings of the pertinent scientific literature, the collation of national health policy experience, and consultations with Ministry officers and recognized national experts. Results: The thrust of the national health policy changes, involving the crucial relationship between service providers and users resulting from such process was summarized by the dictum “Persons Caring for Persons” (In Spanish, “Personas que Atendemos Personas”). In order to extend the impact of this policy dictum, it was decided to inscribe it right under the Ministry’s name on the façade or frontispiece of the Ministry’s central building in Lima, the capital of Peru. Discussion: The focus of health care on persons was based on well considered Peruvian and international experience, particularly those maturing at the World Health Organization since the Alma Ata Declaration. The dictum “Persons Caring for Persons” has remained present in national health discussions as well as on the frontispiece of the Ministry’s central building across several changes in national political leadership over the past 13 years. Conclusions: The policy statement “Persons Caring for Persons”, reflects well considered national experience and wisdom, consistent with growing international aspirations. Its endurance over many years calls for renewed efforts to deepen such perspectives towards greater respect for human rights and the full humanization of health care and social life.
Person Centered Medicine: Core and Diversity
Authors: Mezzich Juan E , Salloum Ihsan M. 
Published: July 2021

In the conceptualization of Person Centered Medicine (PCM) one can recognize core concepts as well as diversity at multiple levels. The core concepts convey vision and depth. Diversity displays plurality, richness and scope. And both are intertwined and articulated through the unfolding process and journey that the construction of PCM represents. This paper briefly elaborates on these complementary perspectives of PCM. And ends introducing a set of papers that illustrate its core and diversity.
Liens entre les satisfactions au travail et dans la vie : identification d’une typologie de profils
Authors: St-Gelais Véronique , Gosselin Eric , Foucher Roland 
Published: July 2021

Introduction et objectifs- Cette recherche vise à analyser la nature potentiellement polymorphique de la relation entre la satisfaction au travail et la satisfaction dans la vie; polymorphie impliquant la coexistence de divers modèles relationnels, dont les effets d’entraînement, de compensation et de segmentation. Les objectifs spécifiques de l’étude sont de vérifier s’il est possible d’élaborer une typologie de profils de relation entre la satisfaction au travail et celle dans la vie, de déterminer si certaines caractéristiques individuelles sont associées à l’adoption d’un profil particulier et de vérifier l’existence de liens entre le profil relationnel et l’engagement organisationnel.Méthode- La collecte des données, recueillies par un questionnaire auto-administré auprès d’un échantillon de 460 enseignants (taux de réponse = 38 %), a été effectuée dans le cadre d’une enquête portant sur le stress et la qualité de vie au travail.Résultats– Les résultats permettent de dégager deux conclusions générales. Premièrement, il est pertinent d’envisager l’existence de cinq profils relationnels entre la satisfaction au et hors travail au lieu des trois auxquels on fait traditionnellement référence. Deuxièmement, les analyses révèlent que les profils de relation entre les satisfactions varient selon l’état civil et le stress au travail et qu’ils sont reliés à l’engagement organisationnel.Conclusion- Ces observations suscitent la réflexion quant à une reconsidération de l’interface entre les domaines de satisfaction et supportent une révision du modèle traditionnel de la relation unique entre ces attitudes.