bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Pro-inflammatory Diet With Risk of Type 2 Diabetes and Hypertension; Results From RaNCD Cohort Study
Authors: Jam Samira Arbabi , Rezaeian Shahab , Najafi Farid , Hamze Behroz , Shakiba Ebrahim , Moradinazer Mehdi , Darbandi Mitra , Hichi Fatemeh , Eghtesad Sareh , Pasdar Yahya 
Published: April 2021

Abstract
Background: Dietary factors and inflammation are associated with most non-communicable diseases (NCDs). The Dietary Inflammatory Index (DII) is a developed validated assessment tool. This study was conducted to assessed association of DII with the hypertension and type 2 diabetes mellitus (T2DM). Methods: This cross-sectional analysis was performed on 9,811 participants of 35 to 65 years of the base-line phase data of Ravansar Non-Communicable Diseases (RaNCD) cohort study. The DII was calculated using 31 parameters food of food frequency questionnaire (FFQ). The estimates were performed using univariable and multivariable logistic regression.Results: The mean DII scores in healthy participants was -2.32± 1.60, in participant with T2DM, hypertension and both were -2.23± 1.59, -2.45± 1.60 and -2.25± 1.60, respectively (P= 0.011). Pre-inflammatory diet was significantly higher in male compared to female (P<0.001). In the most pro-inflammatory diet was significantly higher BMI (body mass index), triglyceride, energy intake, smokers; and was significantly lower socio-economic status (SES), physical activity and HDL-C compared to the most anti-inflammatory diet. Participants with T2DM, hypertension and comorbidity had a significantly higher mean of anthropometry indices (P<0.001) and lipid profile compared to healthy subjects (P<0.001). After adjustment for age, sex and physical activity, the odds of T2DM in the fourth quartile of DII was 1.48 (95% CI: 1.19, 1.85) times higher compared to the first quartile of DII. Conclusions: Pro-inflammatory diet was weak associations with hypertension. Pro-inflammatory diet was significant associations with increasing T2DM and its related risk factors. Modification of diet and lifestyle is suggested to reduce inflammation.
Association of Sleep Disturbances and Cognitive Decline among Cognitively Normal Elders Over Time
Authors: Feng Wei , Kuetche Mandela William Nzoyoum , Zhang Meng , Liu MengMeng , Aklilu Deginet , Wang Wei , Wang XiaoNan , Guo Xiuhua 
Published: April 2021

Abstract
Background: While sleep disturbances (SD) has been shown to be associated with worse cognition, but the causal relationship between the two subjects to debate. Our objective was to investigate the longitudinal impact of SD on cognitive function.Objective: To determine the effect of self-reported clinical diagnosis of SD on longitudinal changes in brain amyloid-PET, CSF-biomarkers (Aβ42, T-tau and P-tau) and cognitive function in cognitively normal.Methods: A total of 463 cognitively normal elders (357 normal and 106 SD) were included. Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants were collected from 2005 to 2020. The generalized linear mixed models adjusting variables which were selected by the Akaike Information Criterion (AIC) and the marginal effect estimation method was used to estimate the risk effect of SD. Cox proportional hazards regression models estimated the relative hazard of Alzheimer’s Disease (AD), among baseline SD patients.Results: The age range of participants was 73.60±5.71 years old, and the female proportion was 43.63%. In adjusted regression models, Participants with baseline SD had higher likelihood of developing worse cognition over subsequent follow-up, PACC (decrease 7.53 points [95%CI, 7.36-7.70]; P<0.001), MMSE (decrease 5.26 points [95%CI, 5.17-5.35]; P<0.001), and CDR–Sum of Boxes (increase 5.61 points [95%CI, 5.67-5.54]; P=0.001). Similarly, Cox regression analysis suggested that sleep disturbances is a risk factor of AD (HR=1.55, 95% CI=1.08 to 2.22).Conclusion: SD probably is a warning sign of AD, because it is associated with greater likelihood of cognitive decline or dementia over time. Associations are likely multifactorial and could be explained by intervening variables in the path from SD to dementia, or by common risk factors for pathological processes in brain. These findings suggest need for more attentions of older adults with sleep compromise.
TRPC channels blockade abolishes septic cardiac dysfunction by hampering intracellular inflammation and Ca2+ leakage
Authors: Cao Wei , Tang Na , Tian Wen , Ma Guang-Yuan , Xiao Xiong , Zhou Lei , Li Ze-Zhi , Liu Xiao-Xiao , Li Chong-Yao , Wu Ke-Han , Liu Wenjuan , Wang Xue-Ying , Gao Yuan-Yuan , Yang Xin , Qi Jianzhao , Li Ding , Liu Yang , Chen Wen-Sheng , Gao Jin-Ming , Li Xiao-Qiang 
Published: April 2021

Abstract
Intracellular Ca2+ dysregulation is a key marker in septic cardiac dysfunction; however, regulation of the classic Ca2+ regulatory modules cannot successfully abolish this symptom. The present study shows that the knockout of transient receptor potential canonical (TRPC) channel isoforms, TRPC1 and TRPC6, can strikingly ameliorate LPS-challenged heart failure and prolong survivability in mice. The LPS-triggered Ca2+ release from the endoplasmic reticulum both in cardiomyocytes and macrophages is significantly inhibited by Trpc1 or Trpc6 knockout. Meanwhile, TRPC’s molecular partner, calmodulin is uncoupled during Trpc1 or Trpc6 deficiency and binds to TLR4’s Pococurante site and atypical isoleucine-glutamine-like motif to block the inflammation cascade. Importantly, blocking the C-terminal CaM/IP3R binding domain in TRPC with chemical inhibitor could markedly obstruct the Ca2+ leak and TLR4-mediated inflammation burst, demonstrating a powerful cardioprotective effect in endotoxemia and polymicrobial sepsis. Our findings provide new insights into the pathogenesis of septic cardiac dysfunction and suggest a novel approach for its treatment.
Enhancement on the Microbial Extracellular Electron Transfers by Modified Lignin Materials: Application on Decolorization of Azo Dye
Authors: Chen Rong-ping , Cai Jia-li , Li Qing , Wei Xin-yuan , Gan Cheng-hao , Min Hui-hua , Yu Lei , Yong Qiang 
Published: April 2021

Abstract
Background: Extracellular electron transfers (EETs) are mainly involved in anaerobic respiration of quinone-respiring strains, which is applicable in many fields, such as microbiological fuel cell, bio-hydrogen production, anoxic denitrification, and bio-reduction of azo dyes. However, this kind of instinctive function of microbes was nonspecific and low efficient, which needed to be improved by addition of exogenous redox mediators (RMs). In this work, vanillin, syringaldehyde and p-hydroxybenzaldehyde, as the precursors of lignin, were functionally modified to RMs in effort to accelerate the bio-reduction azo dyes.Results: The results showed that the decolorization efficiency of MO motivated by modified vanillin were increased from 20% to 95% in less than 12 h. And the modified syringaldehyde was increased to 85% in 24h. According to GC-MS, the modified products of vanillin and syringaldehyde were mainly kinds of phenols, ketones and quinones. The RMs exhibited better electrochemical performances by CV measurement and the •OH radicals were found according to EPR. Under saline condition, the strain, in the presence of RMs, still exhibited a high and stable removal efficiency to MO.Conclusions: The novel RMs of biodegradation to azo dyes were prepared from lignin monomers. The RMs based on bio-materials are environment-friendly and have a remarkable effect in biodegradation of azo dyes. This work may provide a new route for the functional utilization of lignin-resource and a theoretical guidance for efficient biodegradation of azo dye wastewater.
Protective Effects of Atorvastatin and Rosuvastatin on 3,4-methylenedioxymethamphetamine (MDMA)-Induced Spatial Learning and Memory Impairment
Authors: Eslami Majid , Khorshidi Laleh , Ghasemi Maryam , Rashidian Amir , Mirghazanfari Mahdi , Nezhadi Akram , chamanara mohsen , Mirjani Ruhollah 
Published: April 2021

Abstract
3,4‐methylenedioxymethamphetamine (MDMA) or "Ecstasy", which has been used for recreational purposes, is shown to cause learning and memory impairment. Statins, beyond their efficient cholesterol-lowering action through inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG-COA) reductase, possess multiple neuroprotective impacts referred to as pleiotropic effects. In this regard, we aimed to investigate the protective effect of atorvastatin and rosuvastatin in MDMA-induced neurotoxicity. Adult male Wistar rats received atorvastatin (5, 10, 20 mg/kg; orally) and rosuvastatin (5, 10, 20 mg/kg; orally) for 21 consecutive days. Then, Morris water maze (MWM) was performed to examine learning and memory functions. Rats were injected with MDMA (2.5, 5, and 10 mg/kg; I.P) 30 min before training sessions in 4 training days of MWM task. Afterward, rats were sacrificed under general anesthesia and their hippocampuses were dissected to evaluate reactive oxygen species (ROS) production, lipid peroxidation (LPO), and caspase-3 and -9 activities. Our Findings showed that MDMA impaired spatial memory functions and dramatically upregulated ROS production, LPO, and caspase-3 and 9 activities. Also, atorvastatin (5, 10, 20 mg/kg) and rosuvastatin (20 mg/kg) significantly improved memory performances and inhibited upregulation of ROS, LPO, and caspase-3 and -9 activities induced by MDMA. In conclusion, the amelioration of MDMA-induced memory impairment and hippocampal apoptosis through atorvastatin and rosuvastatin could be accredited to the observed suppression of ROS production, LPO, and caspase-3 and -9 activities, since excessive exposure of hippocampus to oxidative stress enhanced apoptotic caspases activities, promoted to neuronal apoptosis.
CAZyme Prediction in Ascomycetous Yeast Genomes Guides Discovery of Novel Xylanolytic Species with Diverse Capacities for Hemicellulose Hydrolysis
Authors: Ravn Jonas L. , Engqvist Martin K. M. , Larsbrink Johan , Geijer Cecilia 
Published: April 2021

Abstract
Background Ascomycetous yeasts from the kingdom fungi inhabit every biome in Nature. While filamentous fungi have been studied extensively regarding their enzymatic degradation of the complex polymers comprising lignocellulose, yeasts have been largely overlooked. As yeasts are key organisms used in industry, understanding their enzymatic strategies for biomass conversion is an important factor in developing new and more efficient cell factories. The aim of this study was to identify polysaccharide-degrading yeasts by mining CAZymes in 332 yeast genomes from the phylum Ascomycota. Selected CAZyme-rich yeasts were then characterized in more detail through growth and enzymatic activity assays. Results The CAZyme analysis revealed a large spread in the number of CAZyme-encoding genes in the Ascomycetous yeast genomes. We identified a total of 224 predicted CAZyme families, including several CAZymes likely involved in degradation of plant polysaccharides. Growth characterization of 40 CAZyme-rich yeasts revealed no cellulolytic yeasts, but several species from the Trichomonascaceae and CUG-Ser1 clades were able to grow on xylan, β-glucan and xyloglucan. Blastobotrys mokoenaii, Sugiyamaella lignohabitans, Spencermartinsiella europaea and several Scheffersomyces species displayed superior growth on xylan and well as high enzymatic activities. These species contained several putative xylanolytic enzymes, including the well-studied xylanase-containing glycoside hydrolase families GH10 and GH30 that appear attached to the cell surface. B. mokoenaii was the only species containing a GH11 xylanase, which was shown to be secreted. Surprisingly, no known xylanases were predicted in the xylanolytic species Wickerhamomyces canadensis, suggesting that this yeast possess novel xylanases. In addition, by examining non-sequenced yeasts closely related to the xylanolytic yeasts, we were able to identify novel species with high xylanolytic capacities. Conclusions Our approach of combining high-throughput bioinformatic CAZyme-prediction with growth and enzyme characterization proved to be a powerful pipeline for discovery of novel xylan-degrading yeasts and enzymes. The identified yeasts display diverse profiles in terms of growth, enzymatic activities and xylan substrate preferences, pointing towards different strategies for degradation and utilization of xylan. Together, the results provide novel insights into how yeast degrade xylan, which can be used to improve cell factory design and industrial bioconversion processes.
Pipelines and Systems for Threshold Avoiding Quantification of LC-MS/MS data
Authors: Brotons Alejandro Sánchez , Eriksson Jonatan , Kwiatkowski Marcel , Wolters Justina , Kema Ido , Barcaru Andrei , Kuipers Folkert , Bakker Stephan , Bischoff Rainer , Suits Frank , Horvatovich Peter 
Published: April 2021

Abstract
The accurate processing of complex LC-MS/MS data from biological samples is a major challenge for metabolomics, proteomics and related approaches. Here we present the Pipelines and Systems for Threshold Avoiding Quantification (PASTAQ) LC-MS/MS pre-processing toolset, which allows highly accurate quantification of data-dependent acquisition (DDA) LC-MS/MS datasets. PASTAQ performs compound quantification using single-stage (MS1) data and implements novel algorithms for high-performance and accurate quantification, retention time alignment, feature detection, and linking annotations from multiple identification engines. PASTAQ offers straightforward parametrization and automatic generation of quality control plots for data and pre-processing assessment. This design results in smaller variance when analyzing replicates of proteomes mixed with known ratios, and allows the detection of peptides over a larger dynamic concentration range compared to widely used proteomics preprocessing tools. The performance of the pipeline is also demonstrated in a biological human serum dataset for the identification of gender related proteins.
A fronto-insular-parietal network for the sense of body ownership
Authors: Moro Valentina , Pacella Valentina , Scandola Michele , Besharati Sahba , Rossato Elena , Jenkinson Paul , Fotopoulou Akaterini 
Published: April 2021

Abstract
Neuropsychological disturbances in the sense of limb ownership (DSO) provide a unique opportunity to study the neurocognitive basis of the sense of body ownership. Previous small sample studies focused on discrete cortical lesions and modular accounts, which cannot explain the modulations of DSO by multisensory, affective and cognitive manipulations. We tested the novel hypothesis that DSO would be associated not only with discrete cortical lesions, but also with disconnections of frontoparietal and fronto-insular white-matter tracts, supporting functional networks for multisensory integration and salience monitoring. To overcome the aforementioned methodological limitations, we drew on an advanced, probabilistic lesion-analysis and Bayesian statistics approach and tested this hypothesis in 49 right-hemisphere patients. Our results reveal that, as predicted, DSO is associated with lesions and disconnections of a fronto-insular-parietal network, suggesting that the sense of body ownership involves the convergence between bottom-up processes of multisensory integration and top-down control and monitoring of sensory salience.
Induction chemotherapy followed by chemoradiotherapy with or without consolidation chemotherapy versus Chemoradiotherapy followed by consolidation chemotherapy for Esophageal Squamous Cell Carcinoma
Authors: Xiang Mingyue , Han Dali , Liu Bo , Zhang Guifang , Gong Heyi 
Published: April 2021

Abstract
Purpose To compare the efficacy and safety of induction chemotherapy followed by concurrent chemoradiotherapy(I-CCRT), induction chemotherapy followed by concurrent chemoradiotherapy and consolidation chemotherapy(I-CCRT-C), and concurrent chemoradiotherapy followed by consolidation chemotherapy(CCRT-C) for locally advanced esophageal squamous cell carcinoma(ESSC). Methods Patients with locally advanced ESCC who underwent definitive chemoradiotherapy with cisplatin plus fluorouracil or docetaxel from February 2012 to December 2018 were retrospectively reviewed. Kaplan-Meier curve was used to estimate survival. Efficacy was assessed using RECIST, version 1.0. Prognosis factors were identified with Cox regression analysis. Results Patients were treated with CCRT-C(n=59), I-CCRT(n=20), and I-CCRT-C(n=48), SCRT(n=119). The median follow-up duration was 73.9 months for the entire cohort. The ORR of the CCRT-C, I-CCRT, and I-CCRT-C, SCRT groups was 89.8%, 70.0%, and 77.1%, respectively ( P = 0.078). The median PFS in the CCRT-C, I-CCRT, and I-CCRT-C groups was 32.5, 16.1, and 27.1 months, respectively ( P = 0.464). The median OS of the CCRT-C, I-CCRT, and I-CCRT-C groups was 45.9, 35.5, and 54.0 months, respectively ( P = 0.788). Cox regression analysis indicated that I-CCRT and I-CCRT had comparable PFS and OS with CCRT-C( P > 0.05). Neutropenia grade ≥ 3 in CCRT-C, I-CCRT, I-CCRT-C, and SCRT groups was 47.5%, 15%, and 33.3% of patients, respectively( P =0.027). Conclusions I-CCRT and I-CCRT-C using cisplatin plus fluorouracil or docetaxel regimen had comparable outcomes with CCRT-C for locally advanced ESCC. I-CCRT and I-CCRT-C seem to have less severe neutropenia than CCRT-C, and potential to be a standard treatment option for locally advanced ESCC.
An Efficient Trajectory representative generation moving data prediction using different Clustering algorithm
Authors: Mishra Vishnu Kumar , Mishra Megha , Dewangan Bhupesh Kumar , Choudhury Tanupriya 
Published: April 2021

Abstract
This paper highlighted Moving and Trajectory Object Cluster (MOTRACLUS) algorithm and analysis the sub-trajectories and real-trajectories algorithm for moving data and suggest a new approach of moving elements. This paper evaluates the Hurricane data measure and mass less data measure entropy of trajectories objects of moving data of Chhattisgarh location. The paper covered Prediction Generation with their distance cluster minimum description length (MDL) algorithm and others corresponding distance cluster (CLSTR) algorithm. This paper highlighted the k-nearest algorithm with least cluster section (LCSS) model and dimensional Euclidean of MDL algorithm. Our algorithm consists of two parts that is partitioning and grouping phase. This paper develops and enhances a cluster of trajectory object and calculates the actual distance of moving object. This algorithm works on the CLSTR algorithm and calculates Trajectory movement of object. In this we evaluate the entropy of moving object by consideration the heuristic parameter.
Atomistic mechanism of cadmium incorporation into hydroxyapatite
Authors: Liu Huan , Lu Xiancai , Cui Xiangjie , Zhang Lijuan , Chan Ting-Shan 
Published: April 2021

Abstract
Hydroxyapatite (HAp) has been widely used to remove cadmium (Cd) in contaminated water and soils via Cd-Ca substitution. The Cd incorporation into HAp affects its structure; however, the detailed mechanism remains unclear. In this study, a series of Cd-substituted hydroxyapatites were synthesized and characterized with various techniques. Cd incorporation causes a decrease in a- and c-lattice parameters due to the radius of Cd2+ being slightly smaller than that of Ca2+. As the Cd content increases, the particle sizes of the synthesized samples decrease and their specific surface areas increase. Raman bands shift linearly and the ν1(PO4) peak at 961 cm−1 becomes broadened with increasing Cd content. Change in X-ray absorption near edge structure (XANES) spectra of the P K-edge indicates distortion of phosphate with Cd incorporation. Total electron yield (TEY) spectra of the Ca L2,3-edge show a decrease in the octahedral symmetry, suggesting preferential occupancy of Cd over the Ca2 site. Extended X-ray absorption fine structure (EXAFS) analysis of the Ca K-edge reveals no obvious change in the local environment of Ca induced by Cd incorporation. However, EXAFS analysis of the Cd K-edge indicates that the substituted Cd occupies one Ca2 site in hexagonal Ca2 positions at low-Cd contents [&lt;10 mol% of Cd/(Cd+Ca)], while both Ca1 and Ca2 sites are occupied at higher Cd contents. This study provides atomistic insight into the mechanism for Cd incorporation in HAp, which will help develop an approach for effective Cd removal using HAp for environmental remediation.
Petrologic evolution of boninite lavas from the IBM Fore-arc, IODP Expedition 352: Evidence for open-system processes during early subduction zone magmatism
Authors: Scholpp Jesse L. , Ryan Jeffrey G. , Shervais John W. , Stremtan Ciprian , Rittner Martin , Luna Antonio , Hill Stephen A. , Atlas Zachary D. , Mack Bradford C. 
Published: April 2021

Abstract
Boninite samples from several intervals within Hole U1439C, recovered during IODP Expedition 352, show highly variable mineral chemistries that imply complex crystallization histories. Small pyroxene grains show oscillatory zoning with cores and zones ranging from pigeonite to augite. Late crystallizing augite has highly variable Al2O3 contents (1.9–13.7 wt%) and Ca-Tschermak component contents (3–13 mol%), which reflect disequilibrium conditions. Large, euhedral, low-Ca pyroxene (i.e., enstatite/clinoenstatite) crystals exhibit complex sector and oscillatory zoning patterns. Cr-rich spinel is found as inclusions both in olivine and low-Ca pyroxene. Early crystallized olivine phenocrysts have embayed and reacted margins, and some early crystallized olivines exhibit zoning. A few olivines have multiple zones, with both normal and reverse zoning between Fo86–92. Olivine xenocrysts also have embayed and reacted margins; however, xenocrysts do not exhibit chemical zoning patterns and have consistent Fo88 compositions. Disequilibrium crystallization of pyroxene rims reflects rapid cooling during an eruption. Sector zoning in low-Ca pyroxenes is the result of crystallization during periods of moderate undercooling between mixing events. Oscillatory, normal, and reverse zoning in olivine and pyroxene appears to have formed in response to multi-stage magma mingling or mixing processes, which introduced additional Ca, Fe, Ti, and Al into parental boninitic melts. The presence of olivine xenocrysts and orthopyroxene indicate equilibrium at 2–4 kbar (Whattam et al. 2020) indicates that boninite magma mixing events likely occurred within shallow magma chambers containing olivine-rich cumulate piles. Large mixing events probably destabilized the magma chamber, resulting in devolatilization and eruption. In contrast, small mixing events lacked the energy to destabilize the chamber, resulting in repeated compositional oscillations in minerals affected by multiple small mixing events.