bluuebunny/crossref_metadata_2025_split huggingface dataset:
Annular Flow in the Upper Esophageal Sphincter Demonstrated with Dynamic 320-row Area Detector Computed Tomography
Authors: Inamoto Yoko , Saitoh Eiichi , Palmer Jeffrey B. 
Published: January 2021

AbstractUnderstanding bolus flow patterns in swallowing (rheology, the study of flow) is fundamental to assessment and treatment of dysphagia. These patterns are complex and poorly understood. A liquid swallow is typically biphasic, including air, so the actual bolus has both liquid and gas phases. We report a novel observation of annular two-phase flow (a ring of liquid around a core of air) as thin liquids passed through the upper esophageal sphincter (UES). Dynamic CT was performed on 27 healthy asymptomatic volunteers swallowing liquid barium in a semi-reclining position. Each subject swallowed 3, 10, and 20 ml of either thin (14 subjects) or thick liquid (13 subjects). Sagittal and axial images were analyzed. Flow patterns in the UES were assessed on cross-sectional images. Annular flow was seen in the majority of subjects with thin liquid but few with thick liquid swallows. The percentage of Annular flow during UES opening was 3 ml 58%, 10 ml 58%, 20 ml 56% in thin and 3 ml 0%, 10 ml 4%, 20 ml 1% in thick. Annular flow was usually observed from the second or third frames after onset of UES opening. The other pattern, Plug flow was seldom seen with thin but was typical with thick liquid swallows. Annular flow was the most common pattern for thin liquids (but not thick liquids) passing through the UES. Annular flow has been defined as a liquid continuum adjacent to the channel wall with a gas continuum (core) in the center of the channel. The two regions are demarcated by a gas–liquid interface. Annular flow is typical for two-phase gas–liquid flow in a vertical or inclined channel. It results from the interaction of viscosity with cohesive and adhesive forces in the two phases. We infer that the difference in flow pattern between thin liquid–air and thick liquid–air boluses resulted from the differing magnitudes of viscous forces.
Was wurde eigentlich aus Prialt®?
Authors: Löschner Denise , Dries Rebecca , Kalff Rolf , Walter Jan , Reichart Rupert 
Published: January 2021

ZusammenfassungHintergrundPrialt® ist seit Februar 2005 von der europäischen Arzneimittelbehörde zugelassen und ist neben Morphin das einzige Analgetikum, welches über die offizielle Marktzulassung in der intrathekalen Schmerztherapie verfügt. Da es nicht über Opioidrezeptoren wirkt, galt es zum Zeitpunkt der Markteinführung als nebenwirkungs- und risikoärmer in der Behandlung chronischer Schmerzen als Morphin. Trotzdem gilt es noch heute als Orphan Drug und Studien über den Langzeiteinsatz und hierunter aufgetretene Nebenwirkungen sind rar.FragestellungWelchen Stellenwert nimmt Prialt® verglichen mit anderen intrathekal verabreichten Analgetika ein? Wie wirken sich die Startdosis und die Geschwindigkeit der Aufdosierung auf die schmerzlindernde Wirkung und das Auftreten von Nebenwirkungen in der Langzeittherapie aus?Material und MethodenZum einen wurden anhand von Arztbriefen retrospektiv alle Patienten erfasst, die zwischen Februar 2005 und dem Ende des Beobachtungszeitraums im Oktober 2018 Ziconotid in Monotherapie in der Neurochirurgie des Universitätsklinikums Jena erhielten. Zum anderen wurden diese Patienten anhand eines erstellten Fragebogens hinsichtlich ihrer Erfahrung mit Ziconotid befragt.ErgebnisseBei allen zwölf in die Studie eingeschlossenen Teilnehmern kam es zu mindestens einer Arzneimittelnebenwirkung. Am häufigsten wurde über Vergesslichkeit und Sensibilitätsstörungen mit jeweils 25 % berichtet. Ein Drittel der Patienten musste die Behandlung aufgrund von Nebenwirkungen beenden. Die mittlere Initialdosis betrug 1,98 µg/Tag.DiskussionTrotz leitliniengerechter Behandlung hat sich Ziconotid am Universitätsklinikum Jena nicht gegen Morphin und andere Opioidanalgetika in der intrathekalen Schmerztherapie durchgesetzt. Die Gründe hierfür sind vielfältig, wobei die enge therapeutische Breite, das häufige Auftreten von Nebenwirkungen und die schwierige therapeutische Handhabung, vor allem im ambulanten Setting, von besonderer Bedeutung sind.
A general approach to multivariable recursive interpolation
Authors: Gombani A. , Michaletzky Gy. 
Published: January 2021

AbstractWe consider here the problem of constructing a general recursive algorithm to interpolate a given set of data with a rational function. While many algorithms of this kind already exist, they are either providing non-minimal degree solutions (like the Schur algorithm) or exhibit jumps in the degree of the interpolants (or of the partial realization, as the problem is called when the interpolation is at infinity, see Rissanen (SIAM J Control 9(3):420–430, 1971) and Gragg and Lindquist (in: Linear systems and control (special issue), linear algebra and its applications, vol 50. pp 277–319, 1983)). By imbedding the solution into a larger set of interpolants, we show that the increase in the degree of this representation is proportional to the increase in the length of the data. We provide an algorithm to interpolate multivariable tangential sets of data with arbitrary nodes, generalizing in a fundamental manner the results of Kuijper (Syst Control Lett 31:225–233, 1997). We use this new approach to discuss a special scalar case in detail. When the interpolation data are obtained from the Taylor-series expansion of a given function, then the Euclidean-type algorithm plays an important role.
Evidence of a tolerogenic vaccine against AIDS in the Chinese macaque prefigures a potential human vaccine
Authors: Andrieu Jean-Marie , Lu Wei 
Published: January 2021

AbstractIn 2006 we discovered a new type of mucosal vaccine against simian immunodeficiency virus (SIV) in Chinese macaques. Here, we review 15 years of our published work on this vaccine, which consists of inactivated SIVmac239 particles adjuvanted with Bacillus Calmette-Guérin, Lactobacillus plantarum, or Lactobacillus rhamnosus. Without adjuvant, the vaccine administered by the intragastric route induced the usual SIV-specific humoral and cellular immune responses but provided no protection against intrarectal challenge with SIVmac239. In contrast, out of 24 macaques immunized with the adjuvanted vaccine and challenged intrarectally with SIVmac239 or SIVB670, 23 were sterilely protected for up to five years, while all control macaques were infected. This protection was confirmed by an independent group from the Pasteur Institute. During the past 15 years, we have identified the mechanism of action of the vaccine and discovered that the vaccinated macaques produced a previously unrecognized class of MHC-Ib/E-restricted CD8+ T cells (which we refer to as tolerogenic CD8+ T cells) that suppressed the activation of SIV-RNA-infected CD4+ T cells and thereby inhibited the (activation-dependent) reverse transcription of the virus, which in turn prevented the establishment of SIV infection. Importantly, we discovered also that the tolerogenic CD8+ T cell subset observed in vaccinated Chinese macaques could also be found in human elite controllers, a small group of HIV-infected patients in whom these tolerogenic CD8+ T cells were shown to naturally suppress viral replication. Given that SIV and HIV require activated immune cells in which to replicate, the specific prevention of activation of SIV-RNA-containing CD4+ T cells by a tolerogenic vaccine approach offers an exciting new avenue in HIV vaccine research.
Spatially Continuous Land-Cover Reconstructions Through the Holocene in Southern Sweden
Authors: O’Dwyer Robert , Marquer Laurent , Trondman Anna-Kari , Jönsson Anna Maria 
Published: January 2021

AbstractClimate change and human activities influence the development of ecosystems, with human demand of ecosystem services altering both land use and land cover. Fossil pollen records provide time series of vegetation characteristics, and the aim of this study was to create spatially continuous reconstructions of land cover through the Holocene in southern Sweden. The Landscape Reconstruction Algorithm (LRA) was applied to obtain quantitative reconstructions of pollen-based vegetation cover at local scales, accounting for pollen production, dispersal, and deposition mechanisms. Pollen-based local vegetation estimates were produced from 41 fossil pollen records available for the region. A comparison of 17 interpolation methods was made and evaluated by comparing with current land cover. Simple kriging with cokriging using elevation was selected to interpolate the local characteristics of past land cover, to generate more detailed reconstructions of trends and degree of variability in time and space than previous studies based on pollen data representing the regional scale. Since the Mesolithic, two main processes have acted to reshape the land cover of southern Sweden, originally mostly covered by broad-leaved forests. The natural distribution limit of coniferous forest has moved southward during periods with colder climate and retracted northward during warmer periods, and human expansion in the area and agrotechnological developments has led to a gradually more open landscape, reaching maximum openness at the beginning of the 20th century. The recent intensification of agriculture has led to abandonment of less fertile agricultural fields and afforestation with conifer forest.
Ecosystem Processes Show Uniform Sensitivity to Winter Soil Temperature Change Across a Gradient from Central to Cold Marginal Stands of a Major Temperate Forest Tree
Authors: Weigel Robert , Henry Hugh A. L. , Beil Ilka , Gebauer Gerhard , Jurasinski Gerald , Klisz Marcin , van der Maaten Ernst , Muffler Lena , Kreyling Juergen 
Published: January 2021

AbstractThe magnitude and frequency of soil frost events might increase in northern temperate regions in response to climate warming due to reduced insulation caused by declining snow cover. In temperate deciduous forests, increased soil frost severity can hamper tree growth and increase the mortality of fine roots, soil fauna and microorganisms, thus altering carbon and nutrient cycling. From single-site studies, however, it is unclear how the sensitivities of these responses change along continental gradients from regions with low to high snowfall. We conducted a gradient design snow cover and soil temperature manipulation experiment across a range of lowland beech forest sites to assess the site-specific sensitivity of tree growth and biogeochemical cycling to soil cooling. Even mild and inconsistent soil frost affected tree increment, germination, litter decomposition and the retention of added 15N. However, the sensitivity of response (treatment effect size per degree of warming or cooling) was not related to prevailing winter climate and snow cover conditions. Our results support that it may be valid to scale these responses to simulated winter climate change up from local studies to regional scales. This upscaling, however, needs to account for the fact that cold regions with historically high snowfall may experience increasingly harsh soil frost conditions, whereas in warmer regions with historically low snowfall, soil frost may diminish. Thus, despite the uniform biotic sensitivity of response, there may be opposing directions of winter climate change effects on temperate forests along continental temperature gradients due to different trends of winter soil temperature.
The effect of alcohol tax changes on retail prices: how do on-trade alcohol retailers pass through tax changes to consumers?
Authors: Wilson Luke B. , Pryce Robert , Angus Colin , Hiscock Rosemary , Brennan Alan , Gillespie Duncan 
Published: January 2021

AbstractThe effectiveness of alcohol duty increases relies on alcohol retailers passing the tax increase on to consumers. This study uses sales data from a market research company to investigate tax pass-through over 11 years for on-premise retailers in England and whether this varies across the price distribution, for different beverage categories and outlet types. Panel data quantile regression analysis is used to estimate the impact of 12 excise duty changes and 3 sales tax changes between 2007 and 2017 on prices. We use product-level quarterly panel data from for 777 alcoholic products. We undertake the regression at all outlets level separating products are analysed in seven broad beverage categories (Beer, Cider, RTDs, Spirits, Wine, Sparkling Wine, and Fortified Wine). We further test sensitivity by disaggregating outlets into seven outlet types. For all seven broad beverage categories, we find that there exists significant differences in tax pass-through across the price distribution. Retailers appear to “undershift” cheaper beverages (prices rise by less than the tax increase) and subsidise this loss in revenue with an “overshift” in the relatively more expensive products. Future modelling of tax change impacts on population subgroups could incorporate this evidence, and this is important because different socio-economic and drinker groups purchase alcohol at different points on the price distribution and hence are affected differently by tax changes. Governments could also potentially incorporate this evidence into future impact assessments.
Enhanced solar radiation pressure model for GPS satellites considering various physical effects
Authors: Duan Bingbing , Hugentobler Urs 
Published: January 2021

AbstractSolar radiation pressure (SRP) is the dominant non-gravitational perturbation for GPS satellites. In the IGS (International GNSS Service), this perturbation is modeled differently by individual analysis centers (ACs). The two most widely used methods are the Empirical CODE orbit Model (ECOM, ECOM2) and the JPL GSPM model. When using ECOM models, a box-wing model or other a priori models, as well as stochastic pulses at noon or midnight, are optionally adopted by some ACs to compensate for the deficiencies of the ECOM or ECOM2 model. However, both box-wing and GSPM parameters were published many years ago. There could be an aging effect going with time. Also, optical properties and GSPM parameters of GPS Block IIF satellites are currently not yet published. In this contribution, we first determine Block-specific optical parameters of GPS satellites using GPS code and phase measurements of 6 years. Various physical effects, such as yaw bias, radiator emission in the satellite body-fixed − X and Y directions and the thermal radiation of solar panels, are considered as additional constant parameters in the optical parameter adjustment. With all the adjusted parameters, we form an enhanced box-wing model adding all the modeled physical effects. In addition, we determine Block-specific GSPM parameters by using the same GPS measurements. The enhanced box-wing model and the GSPM model are then taken as a priori model and are jointly used with ECOM and ECOM2 model, respectively. We find that the enhanced box-wing model performs similarly to the GSPM model outside eclipse seasons. RMSs of all the ECOM and ECOM2 parameters are reduced by 30% compared to results without the a priori model. Orbit misclosures and orbit predictions are improved by combining the enhanced box-wing model with ECOM and ECOM2 models. In particular, the improvement in orbit misclosures for the eclipsing Block IIR and IIF satellites, as well as the non-eclipsing IIA satellites, is about 25%, 10% and 10%, respectively, for the ECOM model. Therefore, the enhanced box-wing model is recommended as an a priori model in GPS satellite orbit determination.
Structural and Pragmatic Language Impairments in Children Evaluated for Autism Spectrum Disorder (ASD)
Authors: Reindal Lise , Nærland Terje , Weidle Bernhard , Lydersen Stian , Andreassen Ole A. , Sund Anne Mari 
Published: January 2021

AbstractPragmatic language impairments are common in neurodevelopmental disorders, especially in autism spectrum disorder (ASD). The relationship between structural language skills and pragmatic competence in children with autistic symptoms, however, is largely unknown. We investigated this relationship based on the Children’s Communication Checklist-2 and early language delay among children (N = 177, 19% females) clinically evaluated for ASD, differentiated into ASD (n = 148) and non-ASD (n = 29). Structural language deficits were common and associated with reduced pragmatic competence in both groups. Pragmatic language impairments were most profound in children with ASD. Early language delay and structural language deficits were less common in females. Our findings suggest that assessment of structural language skills should be included in the evaluation of children with suspected ASD.
Updating Expectations About Unexpected Object Motion in Infants Later Diagnosed with Autism Spectrum Disorder
Authors: Achermann Sheila , Falck-Ytter Terje , Bölte Sven , Nyström Pär 
Published: January 2021

AbstractIn typical development, infants form predictions about future events based on incoming sensory information, which is essential for perception and goal-directed action. It has been suggested that individuals with autism spectrum disorder (ASD) make predictions differently compared to neurotypical individuals. We investigated how infants who later received an ASD diagnosis and neurotypical infants react to temporarily occluded moving objects that violate initial expectations about object motion. Our results indicate that infants regardless of clinical outcome react similarly to unexpected object motion patterns, both in terms of gaze shift latencies and pupillary responses. These findings indicate that the ability to update representations about such regularities in light of new information may not differ between typically developing infants and those with later ASD.
On the Correlation between Energy Spectra and Element Abundances in Solar Energetic Particles
Authors: Reames Donald V. 
Published: January 2021

AbstractIn solar energetic particle (SEP) events, the physical processes of both shock acceleration and scattering during transport can cause energy-spectral indices to be correlated with enhancement or suppression of element abundances versus mass-to-charge ratios $A/Q$
A
/
Q
. We observe correlations for those “gradual” SEP events where shock waves accelerate ions from the ambient coronal plasma, but there are no such correlations for “impulsive” SEP events produced by magnetic reconnection in solar jets, where abundance enhancement in different events vary from $(A/Q)^{+2}$

(
A
/
Q
)

+
2

to $(A/Q)^{+8}$

(
A
/
Q
)

+
8

, nor are there correlations when shock waves reaccelerate these residual impulsive ions. In the latter events the abundances are determined separately, prior to the accelerated spectra. Events with correlated spectra and abundances show a wide variety of interesting behavior that has not been described previously. Small and moderate gradual SEP events, with relative abundances typically depending approximately upon $(A/Q)^{-1}$

(
A
/
Q
)

−
1

and the spectra upon energy $E^{-2.5}$

E

−
2.5

, vary little with time. Large SEP events show huge temporal variations skirting the correlation line; in one case O spectra vary with time from $E^{-1}$

E

−
1

to $E^{-5}$

E

−
5

while abundances vary from $(A/Q)^{+1}$

(
A
/
Q
)

+
1

to $(A/Q)^{-2}$

(
A
/
Q
)

−
2

during the event. In very large events, streaming-limited transport through proton-generated resonant Alfvén waves flattens the spectra and enhances heavy ion abundances prior to local shock passage, then steepens the spectra and reduces enhancements afterward, recapturing the typical correlation. Systematic correlation of spectra and element abundances provide a new perspective on the “injection problem” of ion selection by shocks and on the physics of SEP acceleration and transport.
COVID-19 und Nierentransplantation
Authors: Regele Florina , Oberbauer Rainer 
Published: January 2021

ZusammenfassungNierentransplantierte Patienten stellen während der COVID-19(„coronavirus disease 2019“)-Pandemie eine spezielle Risikogruppe dar. Dies liegt sowohl an den häufig bestehenden Komorbiditäten als auch an der therapeutischen Immunsuppression. Letzterer kommt auch angesichts der stark zu Morbidität und Mortalität beitragenden Hyperinflammation eine komplexe Rolle zu. Bislang publizierte Fallserien zeigen eine hohe Hospitalisierungsrate und eine Mortalität zwischen 13 und 23 % in dieser Population. Die klinische Symptomatik sowie bislang etablierte Risikofaktoren scheinen jenen der Allgemeinbevölkerung zu ähneln. Eine heikle Frage in der Behandlung von an COVID-19 erkrankten Nierentransplantierten ist der Umgang mit der Immunsuppression, welche gemäß aktuellen Empfehlungen stufenweise und in Abhängigkeit vom klinischen Verlauf reduziert werden sollte. Auf der Suche nach wirksamen Therapien gegen SARS-CoV‑2 („severe acute respiratory syndrome coronavirus 2“) wurden zahlreiche in anderen Indikationen etablierte antivirale und antiinflammatorische Substanzen untersucht, wobei bislang nur für die Therapie mit Dexamethason bei Patienten mit Sauerstoffbedarf eine überzeugende Evidenz zu bestehen scheint. Zahllose Studien zu teils auch neuentwickelten Therapien laufen derzeit.
A comparison of methods for determining performance based employee deployment in production systems
Authors: Ast Jonas , Wasseghi Raed , Nyhuis Peter 
Published: January 2021

AbstractEmployee deployment is a crucial process in production systems. Based on qualification and individual performance of employees, deployment decisions can lead to ambiguous outcomes. This paper first reviews the state of the art and further compares two methods based on combinatorial analysis for employee deployment. Therefore, this paper emphasizes the costs and benefits of a Brute Force and an alternative Greedy method. When considering the qualification and individual performance of each employee, both algorithms provide working solutions. In direct comparison, the outcome of the alternative Greedy algorithm is more efficient in terms of calculation time whereas the Brute Force method provides the combination with the global optimum. This means calculation time as well as quality of outcome differ. The exponential growth of employee allocation possibilities depends on the amount of employees and leads to high calculation times, when using a Brute Force method. The comparison of both methods reveal that the proposed alternative Greedy algorithm reaches nearly as high outcomes as the Brute Force does, with significantly less calculation time. Furthermore, this paper offers an insight into the impact of deployment decisions within production systems.