bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unhomeliness of Palestinian Immigrants in Salt Houses (2017) Novel by Hala Alyan
Authors: Ryunanda Mohamad Ralfy 
Published: December 2024

This research explored the notion of unhomeliness experienced by Palestinian immigrants as depicted in Hala Alyan's novel Salt Houses against the backdrop of the Arab-Israeli conflict. this research conducted using the method of qualitative research with the theory of Unhomeliness by Homi K. Bhabha (2004), the result showed how the characters Souad and Alia as Palestinians always believe they are not and perhaps can never be fully accepted by their host societies and they are always considered as outsiders, enemies within country, others and strangers embody the phenomenon of unhomeliness and reflecting their identity as a Palestinian immigrants. The study explores the way cultural identity conflict emerges with unhomeliness that concluded of how the characters issue of how they living for a long time in another country, but they still maintain their identity from their homeland.
DEVELOPING HOTS-BASED E-MODULE TO IMPROVE STUDENTS’ READING SKILL AT SATU NUSA LAMPUNG UNIVERSITY
Authors: Maiza Masfa , Amanah Firma Pradesta , Nafi'ah Homsatun 
Published: December 2024

The rapid development of technology supports a creative and innovative educational process in digital form, especially in providing digital material. E-module, as one of the digital materials, allows the students to access it easily. This research aims to develop a Higher Order Thinking Skill (HOTS)-based e-module of reading for English Literature students at Satu Nusa Lampung University. This teaching material is developed using Canva. This uses the ADDIE research and development (R&D) model in five stages, namely (1) Analysis (2) Design (3) Development (4) Implementation, and (5) Evaluation. The result shows that this e-module that has been developed is valid, practical, and effective. The validity of this e-module reaches a very good category based on the expert’s and validator’s evaluation. The practicability reaches very good based on the students’ responses and lecturers’ evaluation. This e-module is effective and reaches a very good category based on the students’ achievement on the test.
ANALISIS KONDISI HUTAN MANGROVE DAN POTENSI SERAPAN KARBON MENGGUNAKAN DATA SENTINEL-2 DI KABUPATEN PESAWARAN
Authors: Adirama Alfian Zamsami , Permana Rizki Dimas , Alfajrin Achmad Chalid Afif , Dwiputra Mohamad Ashari , Widiya Nanda , Dakhi Sakti Vincensius Sozanolo , Destina Weni Fira 
Published: December 2024

Climate change and global warming continue to occur up to the present. One of the gases significantly influencing climate change is carbon dioxide (CO2). The increase in CO2 can be mitigated by capturing carbon from the atmosphere and storing it in biomass in a process known as carbon sequestration. Forests play a crucial role as a mitigator in reducing global warming and climate change, acting as both a carbon sink and absorber. Mangrove forests, in particular have a high capacity for carbon storage, approximately three times more than terrestrial forests. This research aims to (1) assess the health condition of the mangrove forests in Pesawaran Regency and (2) estimate the CO2 absorption produced by Pesawaran Regency. The study utilizes Sentinel-2 satellite imagery and field data collection. Sentinel-2 images undergo Normalized Difference Vegetation Index (NDVI) transformation. The research results indicate that the mangrove forests in Pesawaran Regency in 2023 are predominantly in good condition, covering an area of 562,31 hectares (99%), while 6,12 hectares (1%) are in a degraded condition. The CO2 absorption by the mangrove forests pesawaran regency is estimated to be 336.367,47 tons CO2 and 591,75 tons CO2/ha.
KINERJA KESATUAN PENGELOLAAN HUTAN WAY PISANG PROVINSI LAMPUNG PASCA UNDANG – UNDANG CIPTA KERJA
Authors: Febrian Ardi , Wulandari Christine , Kaskoyo Hari , Bakri Samsul 
Published: December 2024

The Way Pisang Forest Management Unit (FMU) has significant obligations and roles in overseeing forest areas at the ground level, including forest management and preparing forest management plans; forest utilization; forest use; rehabilitation and reclamation; and forest protection and nature conservation. Performance appraisals are completed to examine the progress of implementing forest management role at the site level. This research aims to provide a performance assessment of the Way Pisang FMU after the enforcement of the Job Creation Law (UUCK) using models and indicators from Forest Watch Indonesia version 2.0 which consists of 9 measures, 28 indicators and 62 quality components. The result shows that the forest management performance index value of Way Pisang FMU is at Medium category, which means that KPH Way Pisang is quite good at managing forest areas. However, there are yet a few rules that require improvement, namely area stabilization, government relations and regulations, and investment mechanisms to ensure the optimization of operationalization of Way Pisang FMU in the site level of forest management.
Aktivitas Baccaurea motleyana Mull.Arg. terhadap Salmonella thypi
Authors: Febrianti Dwi Rizki , Aryzki Saftia , Khadijah Maulida , Kumalasari Eka , Niah Rakhmadhan 
Published: December 2024

Penyakit tifus adalah gangguan pada sistem pencernaan yang menyerang bagian usus halus dan terkadang dapat mempengaruhi aliran darah, kantong empedu, limfa, dan hati. Penyebab utama tifus adalah aktivitas bakteri Salmonella thypi, bakteri ini mampu mengontaminasi makanan ataupun minuman yang tidak terjaga sanitasinya. Baccaurea motleyana Mull.Arg memiliki kandungan senyawa antibakteri, diantaranya golongan flavonoid, saponin, dan tanin. Penelitian ini bertujuan untuk membuktikan aktivitas ekstrak daun rambai dalam menghambat S. thypi. Penelitian ini menggunakan metode ekstraksi maserasi dan uji antibakteri menggunakan metode difusi sumuran menggunakan nutrien agar (NA). Ekstraksi dengan maserasi dilakukan menggunakan pelarut etanol 70%. Kelompok perlakuan pada penelitian ini menggunakan seri konsentrasi ekstrak 10%, 20%, 30%, dan kontrol negatif (water for injection) dengan tiga kali pengulangan. Ukuran diameter zona bening yang terbentuk diukur menggunakan jangka sorong digital. Hasil penelitian menunjukkan bahwa ekstrak daun rambai memiliki efek penghambatan terhadap pertumbuhan bakteri S. thypi. Rerata zona hambat dari ekstrak daun rambai dengan konsentrasi 10%, 20%, dan 30% masing-masing adalah 14,1 mm; 18,8 mm; dan 23,13 mm, sehingga dapat disimpulkan bahwa ekstrak daun B. motleyana memiliki aktivitas terhadap bakteri S. thypi. Kata Kunci: Antibakteri, Zona Bening, Daun Rambai, Difusi Padat, Salmonella thypi Typhoid disease is a disorder of the digestive system that attacks parts of the small intestine and can sometimes affect blood flow, gallbladder, lymph, and liver. The main cause of typhus is the activity of Salmonella thypi bacteria, this bacterium is able to contaminate food or drinks that are not maintained sanitation. Baccaurea motleyana Mull.Arg contains antibacterial compounds, including flavonoids, saponins, and tannins. This study aims to prove the activity of rambai leaf extract in inhibiting S. thypi. This study uses the maceration extraction method and antibacterial test using the well diffusion method using agar nutrients (NA). Extraction by maceration is carried out using a 70% ethanol solvent. The treatment group in this study used a series of 10%, 20%, 30% extract concentrations, and negative control (water for injection) with three repetitions. The size of the diameter of the formed clear zone is measured using a digital caliper. The results showed that rambai leaf extract had an inhibitory effect on the growth of S. thypi bacteria. The average inhibition zone of rambai leaf extract with concentrations of 10%, 20%, and 30% was 14.1 mm, respectively; 18.8 mm; and 23.13 mm, so it can be concluded that B. motleyana leaf extract has activity against S. thypi bacteria.
Comparative Effectiveness of Antihypertensive Drugs
Authors: Herman Hendra , Kamri Andi Maulana , Dahlan Andi Muhriani 
Published: December 2024

Hipertensi sering menjadi penyakit pada orang tua dan kadang-kadang tidak mendapat perhatian karena tingkat pemahaman tentang penyakit dan pengobatan tidak tepat. Tujuan dari studi ini adalah untuk memberikan gambaran tentang pengobatan hipertensi pada pasien rawat inap dan rawat jalan. Metode penelitian ini menggunakan metode deskripsi observasi dengan data retrospektif dengan pengambilan sampel yang berasal dari rekam medik dan resep pada periode Juni-Oktober 2022 yang diberikan untuk penderita hipertensi dengan melihat perbedaan efektivitas berdasarkan kontrol tekanan darah pasien. Populasi penelitian diambil di Pusat Kesehatan Matakali dengan 45 sampel. Hasilnya menunjukkan bahwa paling banyak menggunakan obat hipertensi adalah wanita sebanyak 33 pasien (73,3%), usia 40-59 tahun sebanyak 27 orang (60,0%), dan kelompok obat yang paling banyak digunakan adalah CCB sebanyak 39 (86,7%) jenis obat paling umum adalah amlodipin. Sementara itu, dosis amlodipin yang paling banyak digunakan adalah 5 mg (46,7%) dan kaptopril 25 mg (11,1%). Faktor risiko untuk hipertensi pasien lebih rumit, tetapi beberapa pasien tidak tahu tentang terapi target dan obat yang tepat untuk mereka. Kesimpulan dari penelitian ini adalah tidak ada perbedaan dalam efektivitas dalam menurunkan tekanan darah dari penggunaan amlodipin dan kaptopril. Kata Kunci: Tekanan darah, Efek obat, Hipertensi, Lansia, AmlodipinHypertension is often a disease in the elderly and is sometimes ignored due to a lack of understanding of the disease and inappropriate treatment. The aim of this study is to provide an overview of the treatment of hypertension in hospitalized and street nursing patients. The research method uses the observational description method with retrospective data and sampling from medical records and prescription from June to October 2022 given to hypertensive patients by looking at the difference in effectiveness based on the control of the patient's blood pressure. The research population was taken at the Matakali Health Center with 45 samples. The results showed that the most frequently used hypertensive drugs were women in 33 patients (73.3%), between the ages of 40-59 years as much as 27 patients (60.0%), and the most commonly used drug group was CCBs as much as 39 patients (86.7%). The most common drug type was amlodipine. The risk factors for hypertension patients are more complicated, but some patients do not know about target therapy and the right medication for them. There is no difference in effectiveness in lowering blood pressure between the use of amlodipine and captopril.
Outcomes of Total Ankle Replacement Versus Ankle Arthrodesis for the Treatment of End-Stage Ankle Arthritis
Authors: Glazebrook Mark , Balasubramaniam Umatheepan , Walls Andrew , Younger Alastair S.E. , Penner Murray , Wing Kevin , Dryden Peter J. , Daniels Timothy R. 
Published: December 2024

Abstract:
Despite the increasing utilization of total ankle replacement (TAR) for end-stage ankle arthritis, there remains a paucity of long-term follow-up data comparing arthroplasty to arthrodesis. The aim of the current paper was to provide the long-term clinical outcomes of TAR and ankle arthrodesis (AA), measured with use of validated scoring instruments, in a prospective multicenter cohort of patients with ankle arthritis. This cohort from the Canadian Orthopaedic Foot and Ankle Society (COFAS) Prospective Ankle Reconstruction Database comprised patients who underwent TAR or AA between 2001 and 2007. Data collection included demographics, comorbidities, and Ankle Osteoarthritis Scale and Short Form-36 scores. A total of 211 patients were included in the present study, with a minimum follow-up of 10 years (range, 10 to 18 years) and a mean follow-up of 13.2 years. In this cohort, the baseline characteristics of those who underwent AA and those who underwent TAR differed with respect to mean age (53.8 versus 61.3 years; p < 0.001), smoking status (31% versus 50% with no smoking history; p < 0.001), and inflammatory arthritis diagnosis (2% versus 17%; p = 0.005). Patients in the AA group had a greater chance of having no further surgery following their index procedure compared with those in the TAR group (70% versus 58%; p = 0.02). The TAR and AA groups demonstrated similar functional outcomes. In conclusion, the long-term clinical outcomes of TAR and AA were similar in a diverse cohort in which the treatment was tailored to the condition of the patient.

Level of Evidence:
Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.
Comunidades e cidades compassivas: potencial inovador do design urbano centrado na vida cidadã
Authors: Nesello Priscila , Fachinelli Bertolini Ana Cristina , De Tomasi Ribeiro Vinicius  
Published: December 2024

Objetivo da Pesquisa: Analisar de forma integrativa a pesquisa sobre as cidades compassivas na abordagem do design urbano.Enquadramento Teórico: Esta investigação está inserida no contexto das cidades compassivas no design urbano, em que a centralidade é a vida cidadã. Tal abordagem considera a Teoria da Motivação Humana como instrumento de alavancagem da dignidade humana nesses espaços.Metodologia: Procedeu-se a uma revisão integrativa da literatura, conduzida em sete bases de dados relevantes no campo das Ciências Sociais, que resultou em 37 artigos após a seleção. A análise de conteúdo foi realizada nos artigos completos, e as categorias foram definidas a priori.Resultados: A revisão revela quatro estruturas analíticas que caracterizam a pesquisa em comunidades e cidades compassivas, abrangendo seus modelos e projetos. Os principais resultados oferecem uma compreensão mais profunda do estado atual do conhecimento sobre esse tema.Originalidade: Este estudo se destaca pela abordagem inovadora do conceito de cidades compassivas no design urbano, preenchendo lacunas na literatura existente. As proposições ora apresentadas indicam áreas em que a pesquisa pode contribuir para o desenvolvimento desse campo emergente.Contribuições Teóricas e Práticas: Este estudo oferece implicações significativas para o avanço da teoria em design urbano, além de contribuir para os campos da Administração Pública e da Gestão Social. As implicações também se estendem para a prática, fornecendo insights para a promoção de comunidades compassivas e o desenvolvimento de políticas públicas e estratégias de gestão no contexto urbano.
Palavras-chave: Comunidades e cidades compassivas, Necessidades humanas, Revisão Integrativa, Modelos e projetos.
Os Interesses Acima dos Planos e Ações Estatais em Cenários de Crises Sanitárias e Conflitos Geopolíticos: Uma Análise Histórica e Comparativa
Authors: Calado João Eudes de Souza , Matias-Pereira José , Gonçalves Andrea de Oliveira , Bilhim João Abreu de Faria 
Published: December 2024

Resumo
Objetivo da pesquisa: Identificar e analisar histórica e comparativamente as ações e decisões do planejamento estatal brasileiro nas crises de pandemia e de conflitos geopolíticos, desde a década da Grande Guerra Mundial e de pandemia da Gripe Espanhola no século passado até as crises recentes com a Covid-19 e a Guerra Rússia-Ucrânia.
Enquadramento teórico: Estudo histórico e comparativo sobre as ações do planejamento estatal brasileiro em cenários de crises e conflitos, utiliza como lentes teóricas os sistemas de governos, as ideologias políticas, as teorias da economia e do planejamento, entre outras.
Metodologia: Trata-se de um estudo descritivo, bibliográfico, a partir de uma revisão integrativa qualitativa e sistemática da literatura em fontes que contribuem para a compreensão dos diferentes cenários e processos decisórios.
Resultados: Infere-se que apesar da evolução do planejamento, os desafios recentes não representaram situações de crises ou conflitos desconhecidos e que as decisões se concentram no poder central dos governos e nem sempre alinhadas com os planejadores e interesses da sociedade, causando significativos impactos sociais, econômicos e ampliando-se as crises e os riscos de tensões e conflitos.
Originalidade: A pesquisa apresenta uma análise comparativa e histórica de desafios distintos para o planejamento estatal brasileiro, o estado da arte das crises e de conflitos recentes, o qual as discussões na literatura são incipientes, assim como as discussões em curso no cenário externo.
Contribuições teóricas e práticas: Do ponto de vista teórico, contribui para a revisão histórica do planejamento e processo decisório brasileiro, para o estado da arte da crise sanitária e dos conflitos Rússia-Ucrânia, e em termos práticos, por lançar luz as decisões recentes pautadas nos interesses do centro do poder político e nem sempre ordenadas com o planejamento e as demandas da sociedade, que mais sofre os impactos dessas decisões.
Palavras-chave: Análise Comparativa, Planejamento Estatal, Cenários de Crises e Conflitos.
Modified Physiological Equivalent Temperature for monitoring heat stress: 20-year data from the Falmouth Road Race
Authors: Zhang Xinrui , Ren Kun , Ding Xiaoqing , Gao Binghong 
Published: December 2024

Abstract

Wet-Bulb Globe Temperature (WBGT) is a commonly used tool for monitoring heat stress in outdoor endurance races. The Physiologically Equivalent Temperature (PET) and the Universal Thermal Climate Index (UTCI) have been proposed as alternatives to overcome WBGT's limitations, but PET also has shortcomings and needs improvement for effective use as a screening tool. The aim is to identify the best predictor for Exertional Heat Illness (EHI) and Exertional Heat Stroke (EHS) in outdoor races. Based on a 20 - year dataset from the Falmouth Road Race, generalized linear regression was used to analyze the relationship between the incident rate and the predictors, and model performance was evaluated by leave - one - out cross - validation. The modified version of PET, mPET, had the highest explanation for EHI rate at 63.9%, with WBGT at 34.6%. UTCI and PET had the lowest explanatory power, 21.6% and 20.7% respectively. For EHS, WBGT had the highest explanatory power at 47.2%, and mPET followed with 39.2%. Both PET and UTCI had an explanatory power of 17.3%. In cross - validation for EHI, the predicted values of mPET strongly correlated with the actual values (cor = 0.628, p = 0.003), but in cross - validation for EHS, no significant correlation was found between the predicted and observed values. Overall, mPET is a superior predictor for EHI rate compared with PET, WBGT and UTCI, but for EHS rate, further research is needed to identify the best predictor.
Ovarian Cryopreservation with Rapamycin Improves Fertility Restoration in a Murine Orthotopic Transplantation Model
Authors: Bindels Jules , Squatrito Marlyne , Bernet Laëtitia , Nisolle Michelle , Munaut Carine 
Published: December 2024

Abstract

Background
Currently, the only fertility preservation option of prepubertal patients is ovarian tissue cryopreservation followed by autotransplantation (OTCTP). Once in remission and patients desire to conceive, autotransplantation of frozen/thawed tissue is performed. A major issue of this technique is follicular loss directly after transplantation, mainly due to follicle activation. Our previous research showed that adding rapamycin to the freezing medium counteracted follicle proliferation and activation induced by OTCTP in heterotopic autotransplantation of ovaries in mice. Our current study aimed to test the potential of this approach to improve fertility restoration in mice.
Methods
Forty 4-week-old female C57BL/6 mice underwent unilateral oophorectomy followed by slow-freezing of ovaries with or without rapamycin. After chemically disabling the remaining ovary, orthotopic autotransplantation was performed. After recovery, estrus cycle analysis was conducted using daily vaginal smears. The mice were mated with males for 4 months, and pregnancy outcomes were recorded. After mating, half the females were super-ovulated for oocyte quantification and ovarian analysis, while the others had their ovaries collected for analysis of remaining primordial follicles using immunohistochemistry.
Results
Female mice whose ovaries were cryopreserved with rapamycin prior to chemically disabling the remaining ovary and orthotopic autotransplantation, gave birth to more pups (102 rapamycin, 48 control). The live birth rate was also higher (P = 0.0025) when ovaries were cryopreserved in rapamycin compared to control medium. Additionally, more mice in the rapamycin group gave birth (13 rapamycin, 8 control) with a higher average litter size (P = 0.0837). More mice had primordial follicles left at the end of the experiment in the rapamycin group (P = 0.0397). Superovulation showed a similar number of oocytes collected (P = 0.4462). While rapamycin did not influence cyst formation after autotransplantation, mice that developed ovarian cysts gave birth to fewer pups per dam (P = 0.0119) with a lower live birth rate compared to mice without ovarian cysts (P = 0.0032).
Conclusion
The use of rapamycin improved fertility restoration in mice. Using rapamycin during OTCTP in humans could potentially resolve the massive follicular loss directly after grafting, and thus eventually lead to better opportunities for women to become pregnant.
Spatial and temporal distribution of drug-resistant tuberculosis and associated risk factors in the central region of Uganda (2019- 2023), a retrospective analysis
Authors: Sseddangira Ibrahim , Kabiito Duncan , Kasasa Simon , Kiwanuka Noah 
Published: December 2024

Abstract

Introduction
Drug-resistant tuberculosis (DR-TB) poses a major public health threat in Uganda, especially in densely populated and urbanized Central Uganda. National estimates indicate that 1.6% of new cases and 12.1% of previously treated cases involve DR-TB, but specific data on its distribution and predictors in Central Uganda are limited. This study aimed to map the spatial and temporal distribution of DR-TB and identify associated risk factors from 2019 to 2023 to guide resource allocation.
Methodology
A cross-sectional retrospective study was conducted using data from DR-TB treatment centers in Central Uganda from January 2019 to December 2023. R (Version 4.4.0) statistical software and QGIS version 3.36.3 were used for spatial analysis, and significant clusters were identified using SaTscan’s Kulldorff statistic. Multivariable Poisson regression was employed to identify factors associated with DR-TB using STATA version 14.
Results
Of 803 DR-TB cases, 729 were eligible for analysis. The majority were male (69%), aged 25-34 (34.2%), married (51.9%), and HIV-positive (57.8%). Rifampicin resistance was found in 59% of cases. Kampala and Wakiso had the highest case numbers (30.0% and 24.3%, respectively), with fourteen hotspot clusters identified in these and other districts. Temporal analysis showed fluctuations, peaking in 2019 and 2022. Significant risk factors included age, sex, marital status, occupation, HIV status, and risk group.
Conclusion
DR-TB in Central Uganda clusters in urban districts, driven by urbanization, population density, and socioeconomic factors. Temporal fluctuations, influenced by disruptions like COVID-19, highlight the need for resilient healthcare systems. Key risk factors such as HIV co-infection, malnutrition, and demographics call for targeted interventions, integrated care, and enhanced surveillance.