bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydroxychloroquine Does Not Increase the Risk of Cardiac Arrhythmia in Common Rheumatic Diseases: A Nationwide Population-Based Cohort Study
Authors: Lo Chien-Hsien , Wei James Cheng-Chung , Wang Yu-Hsun , Tsai Chin-Feng , Chan Kuei-Chuan , Li Li-Ching , Lo Tse-Hsien , Su Chun-Hung 
Published: April 2021

ObjectivesHydroxychloroquine (HCQ) is widely used to treat rheumatic diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS). Cardiac arrhythmia has been concerned as important safety issue for HCQ. The aim of this study was to investigate whether hydroxychloroquine increases new-onset arrhythmia among patients with RA, SLE or SS.MethodsThis was a retrospective cohort study that conducted from the longitudinal health insurance database of Taiwan. Patients with newly diagnosed RA, SLE or SS with age ≥20 years old were selected from 2000 to 2012. Patients who received HCQ and without HCQ treatment groups were matched by propensity score to minimize the effect of selection bias and confounders. The Cox proportional hazard model was used to analyze the risk of arrhythmia between the two groups after controlling for related variables.ResultsA total of 15892 patients were selected to participate and finally 3575 patients were enrolled in each group after matching. There was no different risk of all arrhythmia in patients using HCQ than without HCQ (adjusted hazards ratio 0.81, 95% CI 0.61–1.07) and ventricular arrhythmia as well. The incidence of arrhythmia did not increase when HCQ co-administrated with macrolides. The arrhythmia risk was also not different regardless of daily HCQ dose &lt;400mg or ≥400mg or follow-up duration of ≦4 months or &gt;4 months.ConclusionThe administration of HCQ did not increase the risk of all cardiac arrhythmia and ventricular arrhythmia regardless of different duration of treatment (≦4 months or &gt;4 months) or cumulative dose (&lt;400mg or ≥400mg) in patients with common autoimmune diseases such as RA, SLE and SS.
Correlation of Vaccine Responses
Authors: Zimmermann Petra , Ritz Nicole , Perrett Kirsten P. , Messina Nicole L. , van der Klis Fiona R. M. , Curtis Nigel 
Published: April 2021

IntroductionThe humoral response to vaccinations varies widely between individuals. There is no data available on the correlation between responses to different vaccines. In this study, we investigated the correlation of antibody responses between routine vaccine antigens in infants.MethodsOne and seven months after the 6-month vaccinations and one month after the 12-month vaccinations, antibody concentrations to diphtheria, tetanus, pertussis, polio (serotypes 1-3), Haemophilus influenzae type b (Hib), pneumococcus (13 serotypes), meningococcus C, measles, mumps and rubella were measured using fluorescent bead-based multiplex immune-assays. For the correlation of antibody responses, Spearman’s rank correlation coefficients (ρ) with 95% confidence intervals (CI) were calculated between responses to each vaccine antigen.ResultsThe correlation between concentrations of antibodies to the vaccinations ending at 6 months of age was higher one month compared to seven months after vaccination. The strongest correlations at both time points were observed between antibody responses to different polio serotypes, certain pneumococcal serotypes and between responses to diphtheria and pneumococcal (conjugated to a diphtheria toxoid) vaccine antigens. Correlation between responses to tetanus, Hib, pertussis, polio and other vaccine antigens were weak. The correlation between antibody responses to the 12-month vaccine antigens was weaker than to the 6-month vaccine antigens and there was a negative correlation between responses to measles, mumps, rubella vaccine and non-live vaccine antigens (meningococcus C, tetanus and Hib). There was only weak correlation between antibody responses to vaccines of the same type (e.g. conjugated polysaccharide or toxoid vaccines).ConclusionCorrelation between antibody responses to similar antigens in the same vaccine (such as different serotypes of a bacteria or virus), as well as responses to antigens conjugated to similar carrier proteins, are strong. In contrast, correlation between responses to other vaccines are weak. Measuring antibody responses to one or a few vaccine antigens therefore does not offer a reliable surrogate marker of responses to unrelated vaccines.
Recurrent pterygium in Bintulu, Sarawak (Malaysian Borneo): determining its risk factors
Authors: Murugia Loshni , Chong Ka Lung , Lim Lik Thai , Alias Rohanah 
Published: April 2021

Introduction: Pterygium may give rise to astigmatism in addition to causing blindness in advanced stages, reflecting the importance of timely surgical intervention. Despite various operative approaches, the recurrence rate continues to range from 2% to 89%. Therefore, it is essential to investigate the risk factors influencing recurrence to improve therapeutic strategies.
Purpose: To determine the risk factors of pterygium recurrence among the multiethnic cohort of patients in Bintulu, Sarawak (Malaysian Borneo).
Study design: Retrospective cohort.
Materials and methods: This study was conducted in Bintulu Hospital, Sarawak and involved patients who underwent pterygium excision with conjunctival autografting between April 1, 2016 and May 31, 2019. Patients completed at least a year of follow-up for recurrence detection. Collected data included presence of recurrence, sociodemographics, outdoor activities, habits, first-degree family history, pterygium type and location, as well as laterality. Chi-squared test, Fisher’s exact test, and logistic regression analysis were used.
Results: A total of 161 eyes that underwent pterygium excision in 137 patients were identified. Percentage of recurrence was 42%. Mean age during excision was 59.3 ± 11.5 years; age group showed no significance in pterygium recurrence (p = 0.447). Male gender showed statistical significance (p = 0.045, OR 1.90, CI 1.01, 3.58) in chi-squared test but not in logistic regression. Ethnicity, marital status, income, and education level showed no association with recurrence (p > 0.05). Anatomic factors like location (p = 0.353) and laterality (p = 0.955) also showed no association. Smoking (p = 0.867) and alcohol intake (p = 0.397) were insignificant, similar to first-degree family history (p = 0.137). Activities involving sun exposure (p < 0.001, OR 18.34, 95% CI 5.59, 60.17) and recurrent pterygium type (p = 0.001, OR 7.40, 95% CI 1.81, 30.21) supported a positive association with recurrence. Medication adherence (p < 0.001, OR 3.61, 95% CI 1.07, 12.21) and the use of sun protection (p < 0.001, OR 7.90, 95% CI 3.25, 19.19) showed a statistically significant decrease in recurrence.
Conclusion: Activities involving sun exposure, use of sun protection, medication adherence, and recurrent pterygium type have shown to be statistically significant in influencing pterygium recurrence.
Formação Fast Food de Professores: uma análise frankfurtiana
Authors: Manfré Ademir Henrique 
Published: April 2021

Este artigo trata do tema (semi) formação docente. Pretende-se analisar e refletir sobre a nova proposta de formação de professores presente nas Diretrizes Curriculares Nacionais para a formação inicial de professores para a Educação Básica (Resolução n° 2, de 20 de dezembro de 2019) a qual instituiu também a Base Nacional Comum de formação de professores (BNC - Formação). Partiu-se do seguinte questionamento: de que forma as políticas formativas atuais instauram novos modos de (semi) formar a docência? As análises realizadas apontaram que as propostas formativas formuladas pelas políticas nacionais de formação de professores estão subordinadas aos imperativos semiformativos reduzindo a capacidade crítica do pensar e do fazer pedagógicos. Nesse contexto, a proposta deste artigo é refletir sobre a importância de se conceber os caminhos de uma educação comprometida com a formação (Bildung) de indivíduos autônomos capazes de ressignificar a percepção da realidade pela via da crítica. Viu-se na Teoria Crítica um referencial teórico-filosófico que contempla a possibilidade de desenvolver em bases diferentes a análise do processo social em que se insere a educação escolar na atualidade, bem como seus vínculos com a produção da (semi) formação (Halbbildung).

Palavras-chave: Formação (Bildung). Semiformação (Halbbildung). Docência.
PENGARUH GAYA KEPEMIMPINAN DAN BUDAYA ORGANISASI TERHADAP KINERJA PEGAWAI PUSKESMAS MUARA KIBUL KECAMATAN TABIR BARAT KABUPATEN MERANGIN
Authors: A. Roni Khairun , Martyah Martyah 
Published: April 2021

Tujuan dilakukan penelitian ini adalah untuk mengetahui pengaruh gaya kepemimpinan dan budaya organisasi secara parsial maupun simultan terhadap kinerja Pegawai Puskesmas Muara Kibul Kecamatan Tabir Barat Kabupaten Merangin.Metode penelitian ini bersifat Deskriptif Kuantitatif dan menggunakan analisa kualitatif untuk mendiskripsikan data-data. Populasi adalah Pegawai Puskesmas Muara Kibul Kecamatan Tabir Barat Kabupaten Merangin yang berjumlah 51 orang, sampel dalam penelitian ini atas dasar pertimbangan bahwa Kepala Puskesmas tidak termasuk dalam sampel maka sampel yang digunakan berjumlah 50 orang.Hasil penelitian ini, uji parsial variabel gaya kepemimpinan (X1) didapatkan nilai thitung nilai thitung (2.293) > ttabel (2,012), dan variabel budaya organisasi (X2) didapatkan nilai thitung (11.975) > ttabel (2,012), sehingga H0 ditolak dan Ha diterima. Diperoleh nilai Fhitung adalah 148.471 lebih besar dari Ftabel sebesar 3.200. Sehingga H0 ditolak dan Ha ditterima. Maka dapat disimpulkan bahwa variabel gaya kepemimpinan (X1) dan budaya organisasi (X2) secara parsial maupun simultan berpengaruh positif dan signifikan terhadap kinerja (Y) Pegawai Puskesmas Muara Kibul Kecamatan Tabir Barat Kabupaten Merangin. Hasil uji Koefisien Determinasi (R2) diperoleh nilai R Square sebesar 0.899 atau 89,9%, hal ini menunjukan bahwa kontribusi variabel gaya kepemimpinan dan budaya organisasi terhadap kinerja pegawai sebesar 89,9%, sedangkan sisanya sebesar 10,1% dipengaruhi oleh dimensi lain diluar penelitian. Kata Kunci : gaya kepemimpinan, budaya organisasi, kinerja
IMPLEMENTASI SWOT STRATEGI PEMASARAN ONLINEPADA COUNTER SUPER CELL DI KECAMATAN RIMBO BUJANG KABUPATEN TEBO
Authors: Harahap Delila Fitri , Hasim Wahit 
Published: April 2021

Penelitian ini bertujuan untuk mengetahui penjualan produk kepadakonsumen dan ingin lebih tahu banyak tentang produk apa yang ditawarkan.Dari dua strategi yang lebih baik dan lebih efektif untuk dilakukan sehinggaproduk dapat digunakan dan dibeli oleh masyaraka. Penelitian ini menggunakanmetode kualitatif dan analisis deskriptif yang menggunakan analisis SWOTMetode kualitatif seperti Metode Observasi, yaitu metode data denganpengamatan langsung ke counter Super Cell Kecamatan Rimbo BujangKabupaten Tebo dalam memasarkan produk. Dalam penelitian ini penulismengambil data pada Counter Super Cell .Hasil dalam penelitian ini menunjukan bahwa pemasaran online counter Super Cell masuk pada tipe kuadran I. Posisi ini menandakan bahwa counter Super Cell berada di posisi yang kuat dan berpeluang, sehingga sangat memungkinkan untuk terus melakukan pemasaran secara online dan meraih kemajuan secara maksimal. Sedangkan pada analisis SWOT dengan membandingkan nilai IFAS dan EFAS menunjukan bahwa counter Super Cell berada pada situasi SO (strength, opportunities) dengan nilai 7,81 sehingga dapat disimpulkan bahwa strategi pemasaran secara online merupakan posisi yang sangat menguntungkan bagi counter Super Cell memiliki kekuatan dan peluang yang dapat digunakan secara maksimal dalam memasarkan produk secara online. Kata Kunci: Implementasi SWOT Pemasaran Online Dan Offline
PENGARUH PENERAPAN ABSENSI SIDIK JARI (FINGERPRINT) DAN DISIPLIN KERJA PEGAWAI NEGERI SIPIL DALAM MENINGKATKAN KINERJA PEGAWAI PADA BADAN PENGELOLA KEUANGAN DAN ASET DAERAH KABUPATEN BUNGO
Authors: Asman Muhammad , Darmalia Novi 
Published: April 2021

Tujuan penelitian ini adalah untuk mengetahui dan menganalisis pengaruh penerapan absensi sidik jari (Fingerprint) dan disiplin kerja pegawai dalam meningkatkan kinerja pegawai pada Badan Pengelola Keuangan dan Aset Daerah Kabupaten Bungo. Penelitian ini merupakan jenis penelitian Deskriptif Kuantitatif. Populasi dalam penelitian ini adalah Aparatur Sipil Negara (ASN) Badan Pengelola Keuangan dan Aset Daerah Kabupaten Bungo. Yang berjumlah 40 orang. Metode pengumpulan dalam penelitian ini adalah wawancara, kuesioner dan studi dokumentasi. Metode analisis data menggunakan metode deskriptif dan analisis Regresi Linier Berganda Y = -11,177 + 0,311 X1 + 1,878 X2 + eHasil penelitian menunjukkan bahwa variabel Penerapan Absensi Sidik Jari (Fingerprint)mempunyai pengaruh positif namun tidak signifikan sementara variabel disiplin kerja mempunyai pengaruh positif dan signifikan terhadap Kinerja Pegawai Pada Badan Pengelola Keuangan dan Aset Daerah Kabupaten Bungo. Hal ini dapat dilihat Uji signifikan Parsial (Uji t) dan Koefisien Determinasi nilai R Squaresebesar 0.610 atau 61,0% dapat dijelaskan oleh kedua variabel bebas sebesar 61,0% sedangkan sisanya sebesar 39,0% dipengaruhi oleh faktor lain yang tidak diteliti Kata kunci : Absensi Sidik Jari (Fingerprint), Disiplin Kerja, Kinerja Pegawai
Instagram as a virtual art display for medical students
Authors: Pippitt Karly , Chow Candace , Case Gretchen 
Published: April 2021

Implication Statement
We require our medical students to create art as part of a core course. Projects have historically been displayed at our health sciences library. During a rapid adjustment to virtual teaching at the onset of the COVID-19 pandemic, using Instagram to hold a virtual art show was a quickly implemented alternative. With student consent, course directors posted different artwork every weekday for eight weeks to a course account. By capitalizing on the visual strengths and extensive reach of the Instagram platform, we promoted our medical students’ talents both locally and nationally. We plan to use Instagram and in-person displays in the future.
FORTIFIKASI IKAN BARAKUDA (Sphyraena jello) DALAM PEMBUATAN TORTILLA CHIPS
Authors: Azizah Azizah , Purwandhani Siti Nur , Laswati Dyah Titin 
Published: April 2021

Tortilla chips adalah olahan berbahan dasar jagung yang memiliki karakteristik berwarna kuning, renyah, tipis, dan mudah hancur. Tortilla chips mengandug karbohidrat yang tinggi tetapi kandungan proteinnya rendah, untuk meningkatkan kadar protein yang tinggi seperti ikan. Formula tortilla chips dengan ikan Barakuda tidak hanya mempengaruhi kadar protein tetapi juga mempengaruhi sifat kimia dan organoleptik. Tujuan penelitian ini untuk mengetahui perbedaan kualitas tortilla chips yang dibuat dengan fortifikasi daging ikan Barakuda segar dan kukus dengan konsentrasi yang berbeda terhadap karakteristik kimia dan organoleptik. Penelitian ini dilakukan dengan menggunakan RAL 2 Faktorial (ikan Barakuda dan konsentrasi) yaitu formula tortilla chips ikan Barakuda dengan 8 perlakuan dan 3 ulangan. Variabel pengamatan yaitu kadar air, kadar abu, kadar lemak, kadar protein, kadar karbohidrat by difference, dan sifat organoleptik (kerenyahan, warna, flavor, dan kesukaan/overall). Apabila terjadi pengaruh nyata dilanjutkan dengan DMRT (Duncan Multiple Range Test) pada taraf 5%. Hasil penelitian menunjukkan bahwa perlakuan formula tortilla chips berbeda nyata pada kadar air, kadar lemak, kadar protein, kadar karbohidrat, dan sifat organoleptik. Sedangkan kadar abu tidak berbeda nyata. Perlakuan formula tortilla chips ikan Barakuda yang terbaik pada perlakuan ikan segar konsentrasi 7,5% yaitu dengan kadar air 3,76%, kadar abu 4,23%, kadar lemak 36,07%, kadar protein 6,83%, skor mutu kerenyahan 4,3 (renyah-sangat renyah), skor mutu flavor 2,5 (sangat sedikit-sedikit flavor ikan), skoring mutu warna 3,8 (sedikit kuning-kuning), dan skor mutu kesukaan 4,1 (suka-sangat suka).
Perbandingan Struktur Modal Perusahaan Property dan Konstruksi Bangunan Periode 2015-2019
Authors: Yusniawati Nialena , Chomsatu Yuli , Suhendro Suhendro 
Published: April 2021

ABSTRACTCapital structure is a comparison of own capital with foreign capital owned by each company. Capital alone can be divided into retained earnings and company ownership. Meanwhile, foreign capital is short-term debt or long-term debt. The good and bad conditions of the company can be determined through the capital structure. Through the capital structure, the company can allocate funds owned for appropriate business activities as well as useful for the continuity of the company. In general, factors that affect the company's capital structure include profitability, liquidity, company size, sales growth, and asset structure.This study aims to find out the different influences of capital structures on property companies and building construction. This research uses property and building construction companies listed on the Indonesia Stock Exchange in 2015-2019.The result of this study profitability affects the capital structure of property companies, while in building construction companies profitability has no effect on the capital structure. Liquidity in property companies affects the capital structure. This is the same as the result of building construction companies where liquidity affects the capital structure. In property companies the size of the company has an influence on the capital structure, as well as building construction companies that the variable size of the company affects the capital structure. Sales growth has an influence on the capital structure in property companies, while building construction companies sales growth has no effect on the capital structure. The structure of the property company's assets affects the capital structure. The same indicates that the asset structure of building construction companies affects the capital structure. The difference in the influence of the capital structure of property companies is influenced by profitability, liquidity, company size, sales growth, and asset structure. For the capital structure of building construction is influenced by liquidity, company size, and asset structure. As for variable profitability and sales growth in building construction companies has no effect on the capital structure.
Keywords: Profitability, Liquidity, Company Size, Sales growth, Asset Structure, Capital Structure
Pengaruh Tax Avoidance Terhadap Nilai Perusahaan
Authors: Yuliandana Sri , Junaidi Junaidi , Ramadhan Abid 
Published: April 2021

Abstrack
This study is a quantitative study that aims to the effect of tax avoidance on firm value in manufacturing companies listed on the Indonesia Stock Exchange for the 2014-2018 period. The population in this study were manufacturing companies listed and listed on the Indonesia Stock Exchange for the 2014-2018 period, totaling 117 companies. The sampling technique in this study was purposive sampling, in order to obtain 25 sample companies. The method used in analyzing the effect of independent variables on the dependent in this study is panel data regression analysis using Eviews 10 software. The results show that tax avoidance has a negative and insignificant effect on firm value. This shows that the higher the tax avoidance done by the company, the lower the firm value. The limitation in this study is that it does not include elements of other variables outside of tax avoidance which may affect firm value.
Keywords: Tax Avoidance, Firm Value, Indonesia Stock Exchange
Pengaruh Trust Dan Perceived Ease Of Use Terhadap Intention Kaum Milenial Dalam Menggunakan Aplikasi E-Commerce Shopee Yang Dimediasi Oleh Perceived Of Usefulness
Authors: Haning Melaningtyas Tesalonika 
Published: April 2021

This study aims to determine the influence of Trust, Perceived ease of use on Intention with Perceived of Usefulness as Mediation for millennials in using application-based transportation. Many millennials currently use the Shopee e-commerce application. In Indonesia alone, there are various kinds of well-known e-commerce in this community such as Shopee, Pedia Shop, Buka, Lazada and others. Sometimes we get confused between these e-commerce. That's why in this study, researchers want to know what factors influence the millennial generation. Researchers narrow down three variables, trust, perceived ease of use, and perceived usefulness.
This research is using quantitative type of reasearch and choosing 100 people (male & female, 18-26 years old, and uses Shopee e-commerce) assubjects research. Researchers used the SPSS application to test the results of the study. The results showed that the most influential factor in influencing the intention to use application-based transportation was
perceived usefulness, followed by perceived ease of use, and the last one that had the least effect was trust.
Keywords : e-commerce, perceived usefulness, sense of ease of use,
and trust
Pengaruh Green Marketing, Inovasi Produk, dan Brand Image Terhadap Minat Beli
Authors: Sukma P Fika Riskiana , Susanto Susanto , Hutami Lusia Tria Hatmanti 
Published: April 2021

This study aims to determine the effect of Green Marketing, Product Innovation, and Brand Image on Buying Interest in KFC Consumer UST FE Student. Many female students currently buy KFC products. In Indonesia itself, there are various kinds of well-known fast food restaurants in this community such as McDonald's, A&W, Richeese Factory, Hokben, and others. Sometimes we get confused between these restaurants. That's why in this study, researchers want to know what factors influence female students. Researchers narrow down three variables, Green Marketing, Product Innovation, and Brand Image.
This research uses quantitative research and selects 100 people (male & female, 18-26 years old, management or accounting study program and purchasing KFC products) as research subjects. Researchers used the SPSS application to test the results of the study. The results showed that the most influential factor in influencing product purchase intention was Green Marketing, followed by Brand Image, and the last one that had the least influence was Product Innovation.

Keywords: Green Marketing, Product Innovation, Brand Image, Purchase Interest.
Pengaruh Motivasi Intrinsik Komunikasi Verbal Kompensasi Finansial Terhadap Kinerja Individual Karyawan
Authors: Purnomo Afif Joko , Prayekti Prayekti , Herawati Jajuk 
Published: April 2021

ABSTRACT
This study aims to examine whether the effect of intrinsic motivation, verbal communication, financial compensation, on individual employee performance. The research took place at the Department of Population and Civil Registration of Bantul Regency. The sampling method was nonprobability, and the sampling technique used purposive sampling. Data collection was carried out by means of a questionnaire which was directly submitted to the Department of Population and Civil Registration of Bantul Regency. The number of questionnaires that were processed was 48 questionnaires. Data were analyzed using SPSS 23
The results of the t-test research. has an influence on Employee Individual Performance (Y), Based on the results of data processing the Verbal Communication variable has a t-count smaller than t-table (1.024 <1.681) with a probability (0.312) greater than the significant level of 0.05, thus Communication Verbal (X2) partially has no effect on Employee Individual Performance (Y). 0.05, thus Financial Compensation (X3) partially has an effect on Individual Employee Performance (Y). And the f test can be seen that the calculated F value is 5.345 and the f table value is 1.681. The value of F count> F table and the sig value of 0.003 <0.05 (α) so that hypothesis 4 has a positive and significant effect on Intrinsic Motivation, Verbal Communication, Financial Compensation, on Kryawan's Individual Performance at the Department of Population and Civil Registration, Bantul Regency
Key words: Influence of Intrinsic Motivation, Verbal Communication, Financial Compensation, Against Individual Employee Performance in the Department of Population and Civil Registration, Bantul Regency.