bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative survival analysis using the International Stratification Score (ISS) in newly-diagnosed multiple myeloma in the Uruguayan population
Authors: Garrido David Israel , Bove Virginia , Matosas Victoria , Riva Eloisa 
Published: January 2021

Background and aims. Multiple myeloma is a frequent hematologic malignancy, in which the International Stratification Score (ISS) is widely used to estimate the overall survival. However, there are no studies in Latin America evaluating its performance. This study aims to describe the ISS performance in the overall survival estimation for newly diagnosed multiple myeloma patients in Uruguay.
Methods. This is a retrospective registry‐based survival analysis through the Grupo Uruguayo de Mieloma Múltiple (GUMMA) database, including newly diagnosed multiple myeloma patients from January 2001 until May 2019.
Results. 249 patients were included, 51.81% males and an average age of 63.49 years. According to ISS and Durie-Salmon score (DSS), 47.79% and 82.3% were ISS III and DSS III, respectively. Also, 32.3% were DSS B. Auto hematopoietic stem cell transplantation was performed in 31.73% of patients, and bortezomib was used in 44.18% as frontline therapy. The overall survival was 80% for ISS1, 64.9% ISS2, and 48.6% ISS3 (Log-Rank; p <0.01). The average overall survival was 116.5 months for ISS 1, 77.6 months for ISS 2, and 57.8 months for ISS 3. The hazard ratio between ISS II and ISS I was 2.42 (95% CI 1.10-5.33; p<0.05), and 3.94 (95% CI 1.88-8.26; p<0.05) between ISS III and ISS II.
Conclusion. The ISS staging system allows an adequate stratification of patients according to overall survival in the real-practice setting. However, considering the relevance of the new cytogenetic advances, it is necessary to increase the availability and quality of iFISH in Latin America.
Kepemimpinan Kiai Tatang Isakandar dalam Mengembangkan Pondok Pesantren Raudatul Falah
Authors: Nurdin Nurdin , Sarbini Ahmad , Yuliani Yuliani 
Published: January 2021

Penelitian ini bertujuan untuk mengetahui tipe kepemimpinan, cara pengambilan keputusan dan hubungan pemimpin terhadap santri dan lingkungan masyarakat, yang diterapkan K. Tatang Iskandar dalam mengembangkan Pondok Pesantren Raudatul Falah. Penelitian ini menggunakan metode penelitian deskriptif-kualitatif. Teknik pengumpulan data dilakukan melalui observasi dan wawancara mendalam. Analisis data dilakukan melalui interprestasi dan dihubungkan dengan konteks empiris pemimpin Pondok Pesantren Raudatul Falah. Hasil data penelitian menunjukkan bahwa tipe pimpinan Kiai Tatang Iskandar dalam mengembangkan Pondok Pesantren Raudatul Falah adalah kepemimpinan Demokratis dan Karismatik. Hal tersebut dapat dilihat dari cara beliau dalam pengambilan keputusan yang selalu menggunakan kebersamaan, musyawarah untuk mencapai kata mufakat. Kepemimpinan Kiai Tatang Iskandar sangat menjadi panutan yang baik bagi seorang pemimpin, itu terbukti dengan keberadaan Pondok Pesantren Raudatul Falah yang sampai saat ini masih berdiri kokoh di lingkungan masyarakat.
ABSTRACT
This research is in accordance with the idea that to achieve certain goals, cooperation between management and leaders is needed. In this case the leader is very significant to achieve these goals. This leadership includes coordination, organizing and controlling members who determine goals and directions to achieve fulfilling goals to carry out activities and connect with other activities, in addition, the leader is also a direction set, an effective, rational, objective and effective communicator. neutral . This research uses descriptive-qualitative research methods. The research steps taken include; Determination of research locations, research methods, determination of data types, collection of data types, data observation is done through observation and in-depth interviews. Data analysis was carried out through interpretation and related to the empirical context of the leader of the Raudatul Falah Islamic Boarding School. The results of the research data indicate that the leadership of Kiai Tatang Iskandar in developing the Raudatul Falah Islamic Boarding School is Democratic and Charismatic leadership. This can be seen from the way in which decisions always use togetherness, deliberation to reach a consensus. The leadership of Kiai Tatang Iskandar is a very good role model for a leader, it is proven by the existence of the Raudatul Falah Islamic Boarding School which is still standing firmly in the community.
Kiprah Syaikh Maulana Malik Ibrahim pada Islamisasi Gresik Abad ke-14 M dalam Babad Gresik I
Authors: El Firdausy Syarifah Wardah , Azizah Nur , Solichah Solichah , Habibah Umi , Warsadila Dwi Retty , Istiqomah Dwi , Husnawati Ulil Ulifia , Damayanti Sita Arum 
Published: January 2021

This study aims to describe the process of Islamization of Gresik in the 14th century brought by Shaykh Maulana Malik Ibrahim and recorded in the Babad Gresik I. This study uses the qualitative research method based on the study of literature of Babad Gresik I manuscript which has been in the form of Indonesian translation book written by Soekarman (1990). The results of this study are (1) The profile of Shaykh Maulana Malik Ibrahim, including: (a) The arrival of Shaykh Maulana Malik Ibrahim in Gresik region recorded in Babad Gresik I and (b) The death of Shaykh Maulana Malik Ibrahim recorded in Babad Gresik I as well as (2) The methods of da'wah conducted by Shaykh Maulana Malik Ibrahim in the process of Islamization of Gresik in the 14th century including two methods, namely: (a) Da'wah methods through the trade/commerce routes recorded in Babad Gresik I and (2) Da'wah methods through education Islamic boarding schools recorded in Babad Gresik I. Overall, it can be seen that there were some contributions of Syaykh Maulana Malik Ibrahim in the process of Islamization in the 14th century in Gresik that was recorded in Babad Gresik I.
Antibacterial efficiency of heat treatment on teeth root canals
Authors: Daurova F. Y. , Tomaeva D. I. , Podkopaeva S. V. , Taptun Y. A. 
Published: January 2021

Aim. To determine the antibacterial efficiency of heat treatment on teeth root canals by the application of laser radiation and high-frequency diathermocoagulation in the complex curative measures.
Materials and methods. We conducted 120 experiments on the removed teeth that were first placed for 24 hours in natrium chloride isotonic solution. Depending on the type of influence being studied, remote teeth were up-diffused in three groups. The antibacterial action of the high-energy laser radiation and high-frequency diathermocoagulation were studied.
Results. During the experiment, the high antibacterial effect of monoarctic diathermocoagulation was reduced with the use of alternating current at a frequency of 2,64 Mhz in the treatment of the teeth root canals.
Conclusion. The use of diathermocoagulation increases the effectiveness of the treatment measures, which helps to reduce the number of complications and the need for repeated interventions in the treatment of dental caries complications.
Efficiency of cleaning dental structural polymer materials and their resistance to biofouling
Authors: Khafizova F. A. , Mirgazizov R. M. , Khafizov I. R. , Ulyanov Y. A. 
Published: January 2021

Aim. The formation of biofilms, involving microorganisms from the oral cavity, on the surface of various structural dental materials was investigated. Flexistron Plus, Dentalos Plus, and PEEK are used in dental orthopedic practice for prosthetics.
Materials and methods. The difference in quantity depends on the structure and type of plastics, as well as on their mechanical cleaning. All the plastic samples were obtained using atomic force microscopy, which made it possible to detect differences in the microstructure and microrelief of all the types of plastics and to demonstrate bacterial growth on plastics before and after the mechanical cleaning of their surfaces with a toothbrush.
Conclusion. The revealed facts of increased microbial contamination after the mechanical treatment of the surface of polymer materials suggest the need for additional lining with harder materials or the creation of new composites based on these polymers with high hygienic adequacy.
Integrative virogeny of skin-type beta papillomaviruses with concurrent progressive dermatoheliosis as a potential risk of malignant carcinogenesis
Authors: Snarskaya Elena S. , Zhaber Awad Z. 
Published: January 2021

Background: Epidemiological and molecular biological data suggest that papilloma viruses of the beta genus are capable of causing the development of a number of epithelial non-melanocytic skin neoplasms. One of the most probable hypotheses of the influence of cutaneous human papillomaviruses is of great interest, in which they are considered as a cofactor for the promotion of tumor growth of cells already damaged by tumor-initiating epigenetic factors the result of cumulative ultraviolet-induced damage (UVI), that is, photoaging. Cutaneous papillomaviruses of the genus beta infect the stratified squamous epithelium of the skin, which determines the spectrum of clinical targets, which are the morphological structures of the skin epidermis. The oncogenic strategy of carcinogenic papillomaviruses is enhanced by a number of mechanisms for increasing the aggressiveness of tumor growth, an important feature of which is integrative virogeny, the process of incorporating the viral genome into the cellular chromosomes of epithelial cells.
Materials and methods: The article presents the results of our own studies of the incidence and degree of viral load of HPV genus beta DNA in 80 patients (42 patients with dermatogeliosis of IIIIV degrees according to Glogau and epithelial neoplasias, 38 patients without dermatogeliosis) and 40 healthy donors.
Results: We have demonstrated that high rates of detection of papillomaviruses in proliferating tissue identified in immunosuppressive patients with catastrophic manifestations of dermatogeliosis and multiple epithelial neoplasias (papillomas, fibroepitheliomas, keratomas, skin carcinomas) significantly exceed the viral load of virus DNA in normal skin (1.42 0.6 log) and correlate with other clinical and anamnestic signs, in particular, pronounced signs of dermatogeliosis according to Glogau (IV catastrophic stage) and a constitutionally high degree of photosensitivity (IIIII according to Fitzpatrick), which indicates the formation of a "pathological tandem", which is local immunosuppression and multiple proliferative foci of the epidermis.
Efecto de extractos orgánicos naturales sobre la micropropagación in vitro de Vanilla planifolia Jacks. ex Andrews (Orchidaceae)
Authors: Carranza Alvarez Candy 
Published: January 2021

Vanilla planifolia Jacks. ex Andrews es una especie de la familia Orchidaceae que, al igual que otras orquídeas, presenta problemas para su reproducción natural; lo anterior, aunado a la deforestación de su hábitat y la presión de selección para el establecimiento de nuevos cultivos, ha causado que la vainilla se vea amenazada. Por lo anterior, el objetivo general de esta investigación fue generar un protocolo de regeneración in vitro de V. planifolia a través del uso de extractos naturales. Para ello, se cultivaron semillas estériles en medio MS sin reguladores de crecimiento vegetal para obtener protocormos como explantes. Una vez formados los protocormos, estos se sembraron en los medios de cultivo suplementados con los extractos naturales, MPL (plátano), MPI (piña), MCO (agua de coco) y en el medio control. Los resultados mostraron que el mejor tratamiento fue el MPI, en donde se observó la formación de 5.7 ± 3.5 brotes de 36.9 ± 7.3 mm de altura, y la formación de 2.2 ± 0.5 yemas por brote. Además, se logró la formación de 13.0 ± 1.1 raíces por brote con la adición de 0.5 mg L-1 de AIA, y la preaclimatación de las plantas in vitro.
Negative Emotional State dan Cyberbullying Pada Mahasiswa
Authors: Muzdalifah Fellianti , Deasyanti  
Published: January 2021

Cyberbullying is a form of aggressive behavior by using telecommunications media with the aim of embarrassing, threatening, and intimidating certain parties. Cyberbullyings widely applied using mobile media, online chatting (whatsapp, LINE), e-mail, and also online social media such as Facebook, Instagram,or to personal blogs. Cyberbullying evoked negative emotional states namely depression, anxiety, and stress in cyberbullies and cybervictimization. This study provided evidence indicating that college students who experienced in cyberbullying at least 1 week, either cyberbullies or cybervictimization had differences level of negative emotional states,namely depression, anxiety, and stress. The data collection was used the DASS-42 scale to measure negative emotional states (depression, anxiety, and stress). The level of depression, anxiety, and stress were consisted of normal, mild, moderate, severe, and very severe. Meanwhile, Revised Cyber ​​Bullying Inventory-II (RCBI-II) was used to collect cyberbullying data and determined the role in cyberbullying (cyberbullies and cybervictimization). The respondents was 48 cyberbullies and 38 cybervictimization. The result showed that most of 51,1% total of cyberbullies and cybervictimization did not have depression and the rest had different levels of depression. Related to anxiety, cyberbullies showed that 52.1% cyberbullies did not have anxiety. Otherwise in cybervictimization, 28.9% did not have anxiety and another 28.9% were at anxiety levels.Then related to stress, most of 52,3% total of cyberbullies and cybervictimization did not have stress and the rest had different levels of stress.
Keywords: cyberbullying, negative emotional state, college students.
Perbedaan Organizational Citizenship Behavior (OCB) Ditinjau Dari Identifikasi Organisasi Guru SD PNS dan Honorer
Authors: Fitriana Zakia Nurul , Yusuf Munawir , Kirana Anggarini Fadjri 
Published: January 2021

This study aims to find out: (1) differences of organizational citizenship behavior in terms of organizational identification in PNS and honorary elementary school teachers (2) differences of organizational citizenship behavior in terms of organizational identification (3) differences of organizational citizenship behavior in PNS and honorary elementary school teachers. The population was elementary school teachers in Wonosari Subdistrict, using cluster random sampling, a minimum sample of Slovin preliminaries was received by 174 teachers. With a sample of 87 honorary and 89 PNS teachers, uses citizenship organizational behavior (α = 0.907) and organizational identification scale (α = 0.854). With two-way Anova hypothesis test, it was found that there was no difference in organizational citizenship behavior in terms of organizational identification in PNS and honorary teachers (F = 0.974; p> 0.05), there were differences of organizational citizenship behavior in terms of organizational identification ​​( F = 36.768; p <0.05), and there were no differences of organizational citizenship behavior in PNS and honorary teachers (F = 0.139; p> 0.05). The results of the additional analysis prove that there is no difference of organizational citizenship behavior in terms of years of service, gender, age, and salary.
Multilevel Multivariate Modelling of The Effect of Gender and Patient Co-morbidity on Spherocylindrical Refractive Outcome Following Cataract Surgery
Authors: Hughes Rahael , Aristodemou Petros , Sparrow John , Kaye Stephen 
Published: January 2021

Abstract
Purpose To investigate effects of co-morbidities on refractive outcomes following cataract surgery.Design Case series database studyMethods Study population: patients on UK national ophthalmic cataract database. Variables examined included gender, age, diabetic retinopathy, glaucoma, high myopia, inherited eye disease, optic nerve disease, uveitis, pseudoexfoliation, vitreous opacities, retinal pathology, cataract type, previous surgery and posterior capsular rupture. A multivariate normal cross-classified model was fitted to the refractive outcome using Markov Chain Monte Carlo (MCMC) methods with diffuse priors to approximate maximum likelihood estimation. A MCMC chain was generated with a burn-in of 5000 iterations and a monitoring chain of 50,000 iterations. Main Outcome Measure Difference between postoperative and expected refractive outcome Results 490,987 cataract operations were performed on 351,864 patients by 2567 surgeons. Myopic and astigmatic errors were associated with female gender, glaucoma, previous trabeculectomy or vitrectomy, high myopia and increasing age. Hyperopic and astigmatic errors were associated with diabetic retinopathy, pseudoexfoliation and male sex. A large proportion of the unexplained variance in EERO was attributed to unobserved eye-level factors such as biometry measurements and IOL prediction formulae.Conclusions There was minimal variation between surgeons. Co-morbidities and gender accounted for small but significant differences significant differences in expected outcomes.
Integration of Metal-Organic Frameworks into a 3D Interconnected Network for Improved Ion Transport
Authors: Zeng Qinghan , Wang Jia , Li Xin , Ou Yangyuan , He Wenchao , Li Dixiong , Guo Sijia , Xiao Yingbo , Deng Haoyan , Gong Wei , Zhang Qi , Huang Shaoming 
Published: January 2021

Abstract
Metal-organic frameworks (MOFs) have attracted intensive study as solid electrolytes (SEs) in recent years, especially on facilitating ion transport with functionalized channels. However, MOF particles work separately in SEs and numerous interfaces hinder the high-efficiency ion transport, which lowers the performance of solid-state batteries (SSBs) especially at high C-rate. Herein, we constructed continuous ion pathways by integration of MOFs into a 3D interconnected network. Particle arrays of a newly developed MOF (Zr-BPDC-2SO3H) which has single ion transport ability were grown on the bacterial cellulose (BC) nanofibers to provide a linear ion transport network. The interconnected MOFs network exhibits higher ionic conductivity of 7.88 × 10− 4 S cm− 1 at 25 ℃, single ion transport ability (ʈLi+=0.88), wide electrochemical window up to 5.15 V, excellent interface compatibility and capability for supressing lithium dendrites. Most importantly, the SSB fabricated with the interconnected MOFs network shows more than 100% improved specific capacity than the SSB without integration and stable cycling performance at 3 C. This work demonstrates the effectiveness of integrated design and paves new way for developing high-performance SEs based on porous ion conductors.
Dietary Acid Load and the Risk of Cardiovascular Disease: A Prospective Population-based Study
Authors: Mirmiran Parvin , Houshialsadat Zeinab , Bahadoran Zahra , Khalili‑Moghadam Sajjad , Shahrzad Mohammad Karim , Azizi Fereidoun 
Published: January 2021

Abstract
Background: Considering the established association between the dietary acid load and cardiovascular outcomes, as well as the existing inconstancies in the previous studies, we aimed to assess the association between the dietary acid load and the risk of cardiovascular diseases in the framework of the Tehran Lipid and Glucose Study. Methods: Eligible participants (n= 2369, 19- 70 years old, 43.5% men) with no cardiovascular diseases at baseline (2006-2008) were recruited and followed up for a mean period of 6.7 ± 1.4 years. Potential Renal Acid Load and Net Endogenous Acid Production, as the two indexes of dietary acid load, were calculated based on the macronutrient and micronutrient constitutions. The Cox proportional hazard regression model was used to report the association between tertiles of Potential Renal Acid Load and Net Endogenous Acid Production, and 6-years incident risk of cardiovascular diseases.Results: The mean age and body mass index of the participants were 38.5 ± 13.3 years and 26.6 ± 4.8 kg/m2 at baseline, respectively. The incident rate of cardiovascular diseases was reported as 3.3% (79 cases). No significant associations were detected between the Potential Renal Acid Load and the cardiovascular diseases incidence in the crude or the adjusted models (HRs= 0.63; CI: 0.36-1.17; P trend= 0.10). Meanwhile, the Net Endogenous Acid Production index was marginally significantly associated with the crude model (HR= 0.57; CI: 0.33-0.99, P trend= 0.048). Conclusions: Data from the current study were not in favor of an independent association between the dietary acid load and the incidence of cardiovascular diseases within the Iranian population.
Hyperhomogeneity of hydrogen-disordered ice and its origin: the residual entropy compatible with the disparity in hydrogen bond energy
Authors: Matsumoto Masakazu , Yagasaki Takuma , Tanaka Hideki 
Published: January 2021

Abstract
The residual entropy is one of the most crucial properties for the existence of a large number of ice polymorphs. The residual entropy has been estimated by Pauling assuming that there is no large difference between the hydrogen bond energies in ice. This simple model accurately predicts the entropy change of the phase transition between a hydrogen-disordered ice phase and its hydrogen-ordered counterpart. This fact is, however, incompatible with another fact that the difference in the pair interaction energies involved in hydrogen bonds in an ice phase can be larger than the thermal energy of a few kJ/mol. Here we propose a mechanism that reconciles them by considering the equality of the binding energy in each molecule rather than the pair interaction energy of the proximate pair. The topological feature of ice, called the ice rules, allows us to replace the interactions of a water molecule with the other individual molecules by that with the collections of the dipoles represented by directed cycles consisting of O-H vectors. This resummation reveals that molecular environments in ice are extremely homogeneous thereby providing a solid basis for Pauling's model.
Biomarkers Derived From Routine Blood Cell Counts Differentially Predict Disease-Free and Overall Survival After Neoadjuvant Treatment of Triple-Negative Breast Cancer
Authors: Rubovszky Gabor , Meszaros Norbert , Matrai Zoltan , Savolt Akos , Újhelyi Mihaly , Madaras Balazs , Ganofszky Erna , Pinter Tamas , Budai Barna 
Published: January 2021

Abstract
In recent years some serologic parameters emerged as potential prognostic factors. The neutrophil-to-lymphocyte ratio (NLR) has the most evidence; however, other serologic factors were also reported. The only established systemic treatment in triple-negative breast cancer (TNBC) is chemotherapy which is preoperatively applied more widely. For these patients few data are available on which serologic markers would be the best predictor for disease-free (DFS) and overall survival (OS). Data of 137 TNBC patients treated (2005-2016) with neoadjuvant chemotherapy at our center were analyzed. Beyond pathological factors, white blood cell (WBC), neutrophil (NE), lymphocyte (LY) and platelet (PL) counts, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII) were investigated. In univariate analysis, most parameters (NE1, LY1, NLR1, PLR1, SII1) measured at baseline and before the third cycle (NE3, LY3, etc.) of chemotherapy showed significant association with survival. After the exclusion of correlated variables, in multivariate analysis NLR1, Ki67 and pathological stage were independent predictors of DFS and OS. In an exploratory analysis new markers were found: dichotomization by NLR1xNLR3 and PL1/(PL3)2 resulted in significantly different DFS of patients with low and high NLR1, respectively. A high PL3xLY3 level was an exclusive marker of relapse after pathological complete remission.