bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seasonal Predictability of the Quasi‐Biennial Oscillation Based on the Current Dynamical Models
Authors: Zhou Chenguang , Ren Hong‐Li , Xu Wenwen , Jie Weihua , Yin Xunqiang 
Published: January 2025

AbstractThe quasi‐biennial oscillation (QBO) is the dominant mode of interannual variability in the tropical stratosphere and influences climate worldwide. This study investigates the seasonal predictability of QBO in eight dynamical forecasting models from international operational centers and organizations. Results show that current dynamical models have high skills in predicting the QBO evolution benefiting from their capability of characterizing the typical downward propagation of QBO. Further analyses show that most models can reasonably reproduce the QBO teleconnection patterns, but with weaker amplitude than observation, which may be due to the underestimation of the Holton‐Tan effect in models. Prediction skills of the QBO teleconnections to winter surface climate patterns are not yet satisfactory in some models though they have quite high QBO skills. These results provide a comprehensive evaluation of current status of the QBO dynamical seasonal prediction and thus a deeper understanding of the QBO seasonal predictability, which would shed light on predicting QBO and its teleconnection.
Phases of Magmatism and Tectonics Along the Madagascar‐Comoros Volcanic Chain, and Synchronous Changes in the Kinematics of the Lwandle and Somalia Plates
Authors: Rusquet Anaïs , Famin Vincent , Michon Laurent , Quidelleur Xavier , Nauret François , Danišík Martin , Ruffet Gilles , Berthod Carole , Revillon Sidonie , Bachèlery Patrick , Thinon Isabelle , Lemoine Anne , Leroy Sylvie , Zaragosi Sébastien , Thivet Simon , Bernard Julien , Gourbet Loraine , Médard Etienne , Toulier Alix 
Published: January 2025

AbstractThis paper aims to solve the longstanding debate on the origin of the Comoros volcanic archipelago (Mozambique Channel, Indian Ocean) concerning whether it represents a hotspot trail or a boundary between the Lwandle and Somalia plates in possible connection with the East African Rift System (EARS). To achieve this goal, we analyzed rock samples from recently discovered and previously uninvestigated volcanoes and edifices by means of geochemistry and geochronology. Major‐trace element analyses and radiometric dating (40Ar/39Ar, K‐Ar, and (U‐Th)/He) allow us to identify a widespread phase of Comorian volcanism initiated at 9–8 Ma, involving the Zélée, Geyser, and Leven banks, three atolls east of the Comoros. Another tectono‐magmatic phase initiated at 2.5 Ma led to a N‐S widening of seamount volcanism, and to the progressive development of en‐échelon NW‐SE structures. With this new addition of atolls and seamounts, the Comoros Archipelago becomes a ∼700 km‐long, ∼200 km‐wide E‐W chain extending from the Cenozoic volcanoes of Madagascar to the EARS. The reactivation of this chain at 9–8 and 2.5 Ma coincides with abrupt changes in the motion of the Somalia plate relative to the Lwandle plate, and with plate boundary modifications. The en‐échelon reorganization of structures also matches the kinematic evolution of Somalia relative to Lwandle, from transtension (>3 Ma) to pure dextral slip (≤3 Ma) in the northern Mozambique Channel. We conclude that the Madagascar‐Comoros volcanic chain is a branch of the EARS and a plate boundary, further strengthening the link between magmatism and the Rovuma‐Lwandle‐Somalia plate kinematics.
Rainfall‐Driven Extreme Snowmelt Will Increase in the Tianshan and Pamir Regions Under Future Climate Projection
Authors: Yang Tao , Chen Xi , Hamdi Rafiq , Li Lanhai , Cui Fengqi , De Maeyer Philippe , Duan Weili 
Published: January 2025

AbstractSnowmelt and related extreme events can have profound natural and societal impacts. However, the studies on projected changes in snow‐related extremes across the Tianshan Mountains (TS) and Pamir regions have been underexplored. Utilizing regional climate model downscaling and bias‐corrected CMIP6 data, this study examined the changes in snowmelt and water available for runoff (SMROS, rainfall plus snowmelt) during the cold seasons across these regions for historical (1994–2014) and future (2040–2060) periods under shared socioeconomic pathway (SSP) scenarios (SSP245 and SSP585). The results demonstrated that accumulated snowmelt was projected to rise by 17.98% and 20.36%, whereas SMROS could increase by 26.97% and 28.95%, respectively, under SSP245 and SSP585 scenarios. Despite relatively minimal changes in extreme snowmelt, the magnitude of the historical daily maximum extreme SMROS (10‐year return level) was 28.04 mm and was expected to increase by 15.32% and 15.31% under the SSP245 and SSP585 scenarios, respectively, especially in western TS exceeding 26%. Meanwhile, areas with a daily extreme SMROS exceeding 50 mm could rise by over 13.5%. A notable rise in daily extreme SMROS and its area occupation in high intensity highlighted an increased risk of rainfall‐driven extreme snowmelt events. The absolute increase in snowfall and frequent snow‐rain phase transitions during the cold season under climate warming (SSP245: 2.19°C and SSP585: 2.22°C) benefits the increase in high‐intensity rain‐on‐snow events, leading to extreme SMROS augmentation. The findings emphasize the significant role of rainfall‐trigger snowmelt events in exacerbating extreme snowmelt in a warming climate.
Host-microbe computational proteomic landscape in oral cancer revealed key functional and metabolic pathways between Fusobacterium nucleatum and cancer progression
Authors: Muñoz-Grez Camila Paz , Vidal Mabel Angélica , Rojas Tamara Beatriz , Ferrada Luciano Esteban , Zuñiga Felipe Andrés , Vera Agustin Andrés , Sanhueza Sergio Andrés , Quiroga Romina Andrea , Cabrera Camilo Daniel , Antilef Barbara Evelyn , Cartes Ricardo Andrés , Acevedo Milovan Paolo , Fraga Marco Andrés , Alarcón-Zapata Pedro Felipe , Hernández Mauricio Alejandro , Salas-Burgos Alexis Marcelo , Tapia-Belmonte Francisco , Yáñez Milly Loreto , Riquelme Erick Marcelo , González Wilfredo Alejandro , Rivera Cesar Andrés , Oñate Angel Alejandro , Lamperti Liliana Ivonne , Nova-Lamperti Estefanía 
Published: January 2025

AbstractOral squamous cell carcinoma (OSCC) is the most common manifestation of oral cancer. It has been proposed that periodontal pathogens contribute to OSCC progression, mainly by their virulence factors. However, the main periodontal pathogen and its mechanism to modulate OSCC cells remains not fully understood. In this study we investigate the main host-pathogen pathways in OSCC by computational proteomics and the mechanism behind cancer progression by the oral microbiome. The main host-pathogen pathways were analyzed in the secretome of biopsies from patients with OSCC and healthy controls by mass spectrometry. Then, functional assays were performed to evaluate the host-pathogen pathways highlighted in oral cancer. Host proteins associated with LPS response, cell migration/adhesion, and metabolism of amino acids were significantly upregulated in the human cancer proteome, whereas the complement cascade was downregulated in malignant samples. Then, the microbiome analysis revealed large number and variety of peptides from Fusobacterium nucleatum (F. nucleatum) in OSCC samples, from which several enzymes from the L-glutamate degradation pathway were found, indicating that L-glutamate from cancer cells is used as an energy source, and catabolized into butyrate by the bacteria. In fact, we observed that F. nucleatum modulates the cystine/glutamate antiporter in an OSCC cell line by increasing SLC7A11 expression, promoting L-glutamate efflux and favoring bacterial infection. Finally, our results showed that F. nucleatum and its metabolic derivates promote tumor spheroids growth, spheroids-derived cell detachment, epithelial-mesenchymal transition and Galectin-9 upregulation. Altogether, F. nucleatum promotes pro-tumoral mechanism in oral cancer.
Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice, monkeys and humans
Authors: Huang Shishu , Gao Dashuang , Li Zhenxia , He Hongchen , Yu Xi , You Xuanhe , Wu Diwei , Du Ze , Zeng Jiancheng , Shi Xiaojun , Hu Qinshen , Nie Yong , Zhang Zhong , Luo Zeyu , Wang Duan , Zhao Zhihe , Li Lingli , Wang Guanglin , Wang Liping , Zhou Zongke , Chen Di , Yang Fan 
Published: January 2025

AbstractOsteoarthritis (OA) is a degenerative joint disease accompanied with the loss of cartilage and consequent nociceptive symptoms. Normal articular cartilage maintains at aneural state. Neuron guidance factor Semaphorin 3A (Sema3A) is a membrane-associated secreted protein with chemorepulsive properties for axons. However, the role of Sema3A in articular cartilage is still not clear. In the present studies, we investigated the functions of Sema3A in OA development in mice, non-human primates, and patients with OA. Sema3A has a protective effect on cartilage degradation, validated by the organoid culture in vitro and confirmed in chondrocyte-specific Sema3A conditional knockout mice. We demonstrated that Sema3A is a key molecule in maintaining cartilage homeostasis from chondrocyte hypertrophy via activating the PI3K pathway. The potential usage of Sema3A for OA treatment was validated in mouse and Rhesus macaque OA models through intra-articular injection of Sema3A, and also in patients by administering Sema3A containing platelet-rich plasma into the knee joints. Our studies demonstrated that Sema3A exerts a critical role in inhibiting neurite ingrowth and preventing chondrocyte hypertrophy in cartilage, and could be potentially used for OA treatment.
High patient acceptance of immediately sequential bilateral cataract surgery (ISBCS) as part of a one-stop see-and-treat pathway within an innovative NHS cataract unit
Authors: Alsusa Maher , Ahmad Shakeel , Smith Zoe , Evans Sam , Wilkinson Elizabeth , Roberts Harry 
Published: January 2025

Abstract
Background
Constituting ~0.5% of all NHS cataract operations, national provision of immediately sequential bilateral cataract surgery (ISBCS) is limited. Combining offering ISBCS within a novel one-stop see-and-treat (S&T) cataract pathway would offer patients the opportunity for two cataract operations in a single hospital visit. Patient acceptance of ISBCS amongst urban populations has been investigated. However, little is understood about ISBCS acceptance rurally.

Methods
Retrospective observational study at the Nightingale Hospital, Exeter investigating patient acceptance of ISBCS within S&T; following the implementation of a S&T cataract pathway entailing a pre-operative patient-clinician telephone consultation and subsequently scheduled single date of assessment and surgery. Patient acceptance and factors potentially influencing decisions were investigated.

Results
200 patient telephone consultations between 22nd August 2023 and 9th January 2024 were evaluated. 198 (99%) patients referred were suitable for S&T cataract surgery, of whom 109 (54.5%) were deemed eligible for offering ISBCS S&T cataract surgery. Of the eligible participants, 78 (71.56%) favoured ISBCS. No significant differences in age, sex, distance from hospital or refractive data were identified between ISBCS accepting and declining participants.

Conclusions
Our results illustrate a high patient acceptance rate (71.56%) of ISBCS within our population in contrast with published national rates. Offering ISBCS within a S&T model would allow patients to benefit from having both cataracts assessed and treated within a single hospital visit.
The transcription factor GABPA is a master regulator of naive pluripotency
Authors: Zhou Chengjie , Wang Meng , Zhang Chunxia , Zhang Yi 
Published: January 2025

Abstract
The establishment of naive pluripotency is a continuous process starting with the generation of inner cell mass (ICM) that then differentiates into epiblast (EPI). Recent studies have revealed key transcription factors (TFs) for ICM formation, but which TFs initiate EPI specification remains unknown. Here, using a targeted rapid protein degradation system, we show that GABPA is not only a regulator of major ZGA, but also a master EPI specifier required for naive pluripotency establishment by regulating 47% of EPI genes during E3.5 to E4.5 transition. Chromatin binding dynamics analysis suggests that GABPA controls EPI formation at least partly by binding to the ICM gene promoters occupied by the pluripotency regulators TFAP2C and SOX2 at E3.5 to establish naive pluripotency at E4.5. Our study not only uncovers GABPA as a master pluripotency regulator, but also supports the notion that mammalian pluripotency establishment requires a dynamic and stepwise multi-TF regulatory network.
International multicenter validation of AI-driven ultrasound detection of ovarian cancer
Authors: Christiansen Filip , Konuk Emir , Ganeshan Adithya Raju , Welch Robert , Palés Huix Joana , Czekierdowski Artur , Leone Francesco Paolo Giuseppe , Haak Lucia Anna , Fruscio Robert , Gaurilcikas Adrius , Franchi Dorella , Fischerova Daniela , Mor Elisa , Savelli Luca , Pascual Maria Àngela , Kudla Marek Jerzy , Guerriero Stefano , Buonomo Francesca , Liuba Karina , Montik Nina , Alcázar Juan Luis , Domali Ekaterini , Pangilinan Nelinda Catherine P. , Carella Chiara , Munaretto Maria , Saskova Petra , Verri Debora , Visenzi Chiara , Herman Pawel , Smith Kevin , Epstein Elisabeth 
Published: January 2025

Abstract
Ovarian lesions are common and often incidentally detected. A critical shortage of expert ultrasound examiners has raised concerns of unnecessary interventions and delayed cancer diagnoses. Deep learning has shown promising results in the detection of ovarian cancer in ultrasound images; however, external validation is lacking. In this international multicenter retrospective study, we developed and validated transformer-based neural network models using a comprehensive dataset of 17,119 ultrasound images from 3,652 patients across 20 centers in eight countries. Using a leave-one-center-out cross-validation scheme, for each center in turn, we trained a model using data from the remaining centers. The models demonstrated robust performance across centers, ultrasound systems, histological diagnoses and patient age groups, significantly outperforming both expert and non-expert examiners on all evaluated metrics, namely F1 score, sensitivity, specificity, accuracy, Cohen’s kappa, Matthew’s correlation coefficient, diagnostic odds ratio and Youden’s J statistic. Furthermore, in a retrospective triage simulation, artificial intelligence (AI)-driven diagnostic support reduced referrals to experts by 63% while significantly surpassing the diagnostic performance of the current practice. These results show that transformer-based models exhibit strong generalization and above human expert-level diagnostic accuracy, with the potential to alleviate the shortage of expert ultrasound examiners and improve patient outcomes.
Psychological profiles associated with mental, cognitive and brain health in middle-aged and older adults
Authors: Bartrés-Faz David , Demnitz-King Harriet , Cabello-Toscano María , Vaqué-Alcázar Lídia , Saunders Rob , Touron Edelweiss , Cattaneo Gabriele , Gonneaud Julie , Klimecki Olga , Bargalló Núria , Sánchez-Solana Javier , Tormos José M. , Chételat Gäel , Pascual-Leone Álvaro , Marchant Natalie L. ,   the Medit-Ageing Research Group, André Claire , Bachelet Romain , Baez Lugo Sebastian , Chocat Anne , Collette Fabienne , Coll-Padros Nina , Dautricourt Sophie , De La Sayette Vincent , Delarue Marion , Ferrand Devouge Eglantine , Frison Eric , Goldet Karine , Jessen Frank , Krolak-Salmon Pierre , Kuhn Elizabeth , Landeau Brigitte , Lefranc Valérie , Lutz Antoine , Mezenge Florence , Meiberth Dix , Michel Laurence , Molinuevo José Luis , Ourry Valentin , Poisnel Géraldine , Quillard Anne , Rauchs Géraldine , Salmon Eric , Schild Ann-Katrin , Schimmer Corinne , Smagghe Delphine , Smith Rhonda , Schlosser Marco , Vuilleumier Patrik , Wallet Cédrick , Walker Zuzana , Whitfield Tim , Wirth Miranka 
Published: January 2025

AbstractPsychological characteristics are associated with varying dementia risk and protective factors. To determine whether these characteristics aggregate into psychological profiles and whether these profiles differentially relate to aging health, we conducted a cross-sectional investigation in two independent middle-aged (51.4 ± 7.0 years (mean ± s.d.); N = 750) and older adult (71.1 ± 5.9 years; N = 282) cohorts, supplemented by longitudinal analyses in the former. Using a person-centered approach, three profiles emerged in both cohorts: those with low protective characteristics (profile 1), high risk characteristics (profile 2) and well-balanced characteristics (profile 3). Profile 1 showed the worst objective cognition in older age and middle age (at follow-up), and most rapid cortical thinning. Profile 2 exhibited the worst mental health symptomology and lowest sleep quality in both older age and middle age. We identified profile-dependent divergent patterns of associations that may suggest two distinct paths for mental, cognitive and brain health, emphasizing the need for comprehensive psychological assessments in dementia prevention research to identify groups for more personalized behavior-change strategies.
Monitoring CO as a plant signaling molecule under heavy metal stress using carbon nanodots
Authors: Mondal Shrodha , Sarkar Olivia , Mandal Santi M. , Chattopadhyay Ansuman , Sahoo Prithidipa 
Published: January 2025

Though CO is a significant environmental pollutant, it serves a pivotal role as a signaling molecule in plants. A novel fluorescent nanodot has been developed for in vivo monitoring of CO inside the plant cells.
Distributed zeroth‐order online optimization with communication delays
Authors: Inoue Keito , Hayashi Naoki , Takai Shigemasa 
Published: January 2025

AbstractThis paper investigates distributed online optimization in a networked multiagent system, where each agent has its own private objective and constraint functions that vary over time. In many real‐world scenarios, computing the gradient of the cost function can be challenging, especially when agents have limited computational capabilities. Moreover, communication delays are common in practical networked systems due to various factors. This paper considers a unified framework for distributed online optimization that can handle bandit feedback and communication delays feedback simultaneously. A distributed primal‐dual algorithm is proposed that utilizes bandit feedback, in which the agents estimate the gradients of their objective and constraint functions by sampling the function values. An enlarged network model that incorporates the delayed information exchanged among the agents is introduced. Through theoretical analysis, it is shown that the proposed algorithm achieves sublinear upper bounds on both the dynamic regret and the constraint violation despite communication delays.
Connection between planetary He I λ10 830 Å absorption and extreme-ultraviolet emission of planet-host stars
Authors: Sanz-Forcada J. , López-Puertas M. , Lampón M. , Czesla S. , Nortmann L. , Caballero J. A. , Zapatero Osorio M. R. , Amado P. J. , Murgas F. , Orell-Miquel J. , Pallé E. , Quirrenbach A. , Reiners A. , Ribas I. , Sánchez-López A. , Solano E. 
Published: January 2025

Context. The detection of the He I λ10 830 Å triplet in exoplanet atmospheres has opened a new window for probing planetary properties, including atmospheric escape. Unlike Lyman α, the triplet is significantly less affected by interstellar medium (ISM) absorption. Sufficient X-ray and extreme ultraviolet (XUV) stellar irradiation may trigger the formation of the He I triplet via photoionization and posterior recombination processes in the planet atmospheres. Only a weak trend between stellar XUV emission and the planetary He I strength has been observed so far.
Aims. We aim to confirm this mechanism for producing near-infrared He I absorption in exoplanetary atmospheres by examining a substantial sample of planetary systems.
Methods. We obtained homogeneous measurements of the planetary He I line equivalent width and consistently computed the stellar XUV ionizing irradiation. Our first step was to derive new coronal models for the planet-host stars. We used updated data from the X-exoplanets database, archival X-ray spectra of M-type stars (including AU Mic and Proxima Centauri), and new XMM-Newton X-ray data recently obtained for the CARMENES project. These data were complemented at longer wavelengths with publicly available HST, FUSE, and EUVE spectra. A total of 75 stars are carefully analyzed to obtain a new calibration between X-ray and extreme ultraviolet (EUV) emission.
Results. Two distinct relationships between stellar X-ray emission (5–100 Å) and EUVH (100–920 Å) or EUVHe (100–504 Å) radiation are obtained to scale the emission from late-type (F to M) stellar coronae. A total of 48 systems with reported planetary He I λ 10 830 Å studies, including 21 positive detections and 27 upper limits, exhibit a robust relationship between the strength of the planetary He I feature and the ionizing XUVHe received by the planet, corrected by stellar and planetary radii, as well as the planet’s gravitational potential. Some outliers could be explained by a different atmospheric composition or the lack of planetary gaseous atmospheres. This relation may serve as a guide to predict the detectability of the He I λ 10 830 Å absorption in exoplanet atmospheres.
Similar-mass versus diverse-mass planetary systems in wind-driven accretion discs
Authors: Zhao Yunpeng , Matsumura Soko 
Published: January 2025

Context. Many close-in multiple-planet systems show a peas-in-a-pod trend, where sizes, masses, and orbital spacing of neighbouring planets are comparable to each other. On the other hand, some planetary systems have a more diverse size and mass distribution, including the Solar System. Classical planet formation models tend to produce the former type of planetary systems rather than the latter, and the origin of their difference is not well understood.
Aims. Recent observational and numerical studies support the disc evolution that is largely driven by magnetic winds rather than by the traditional disc’s viscosity alone. In such a wind-driven accretion disc, the disc mass accretion rate varies radially, instead of being constant in radius as in the classical viscously accreting disc. We investigate how the wind’s efficiency in removing the disc mass affects the outcome of planet formation and migration.
Methods. We performed single-core planet formation simulations via pebble accretion in wind-driven accretion discs. We varied the wind’s efficiency via the magnetic lever arm parameter λ and studied the outcome of planet formation and migration by considering a range of initial disc masses and disc accretion timescales.
Results. Our simulations show that higher λ discs with less wind mass loss lead to faster formation and migration of planets and tend to generate similar-mass planetary systems, while lower λ discs lead to slower formation and migration as well as more diverse- mass planetary systems. Furthermore, we find that a planetary system with a mass jump happens for all λ cases as long as the planet formation timescale is comparable to the disc accretion timescale, but the jump is larger for lower λ discs. The super-Earth systems accompanied by cold Jupiters can be generated in such systems, and we find their frequencies are higher in metal-rich discs, which agrees with the observational trend. Our simulations indicate that similar-mass and diverse-mass systems are approximately separated at λ ∼ 2–3.