bluuebunny/crossref_metadata_2025_split huggingface dataset:
TARIF, KESADARAN DAN SOSIALISASI PAJAK TERHADAP PENINGKATAN PENERIMAAN PAJAK MELALUI KEPATUHAN WAJIB PAJAK SEBAGAI VARIABEL INTERVENING (Implementasi PP 23 Tahun 2018)
Authors: Rudianti Walid 
Published: May 2021

ABSTRACT
This research is motivated by several things. In 2019 the UMKM tax sector is still far below the target (PP 23 is not very influential) and observations that researchers have made in the Banjarnegara District area, show that many MSME do not know about the implementation of the new PP 23 2018 tariff. This research method uses quantitative methods with data collection techniques through distributing questionnaires. Sampling was done by using simple random sampling technique. Hypothesis testing uses regression analysis of mediating variables with the causal step method.
The results showed that partially the tariff has a significant positive effect on increasing tax revenue. awareness does not have a significant positive effect on increasing tax revenue and tax socialization has a significant positive effect on increasing tax revenue. Furthermore, tariffs have a significant positive effect on taxpayer compliance, awareness has a significant positive effect on taxpayer compliance and tax socialization does not have a significant positive effect on taxpayer compliance. then taxpayer compliance has a significant positive effect on increasing tax revenue. for taxpayer compliance mediates the relationship between rates and increased tax revenue. Taxpayer compliance does not mediate the relationship between taxpayer awareness and increased tax revenue. and taxpayer compliance mediates the relationship between tax socialization and increased tax revenue.
Short communication: Effect of pre-activated Saccharomyces cerevisiae or malate salts on fermentation of ground barley grain under in vitro conditions simulating intensive ruminant feeding
Authors: Amanzougarene Zahia , Yuste Susana , Fondevila Manuel 
Published: May 2021

Aim of study: To determine the dose response of Saccharomyces cerevisiae on rumen fermentation of concentrates, and to compare it with the effect of malate salts.Material and methods: S. cerevisiae (0.7, 1.4 and 2.1 mg/g) and malic acid salts (4, 8 or 12 mg/g) were added to barley and compared with barley alone (CTL), in three 24 h in vitro incubation series, using rumen inocula from beef cattle receiving a high concentrate diet. Yeasts were pre-activated by aerobic incubation for 24 h at 30ºC. Incubation pH was recorded at 8 and 24 h and volatile fatty acids (VFA) and lactate at 8 h were analysed.Main results: Gas produced with S. cerevisiae was higher than malate (p<0.001). Yeast addition linearly (p<0.01) and quadratically (p<0.05 at 4 h and from 10 to 18 h) increased gas production, but no dose response to malate levels was observed. Dry matter disappearance at 24 h was not affected by S. cerevisiae but increased linearly with malate. Microbial mass linearly increased with the level of yeast (p<0.01) and malate (p=0.09). Adding yeasts did not affect 8 h total VFA concentration compared with CTL, but linear valerate (p<0.01) and butyrate (p=0.092) increases, and a decrease of acetate (p=0.064) were detected. Malate salts linearly increased (p<0.05) total VFA concentration but did not affect VFA proportions.Research highlights: Addition of active yeasts linearly increased barley fermentation and microbial synthesis, whereas the effect of malate salts was of minor magnitude.
De ontwikkeling en implicaties van kinder- en mensenrechten op het gebied van klimaatverandering
Authors: Wewerinke-Singh M.J. , Stein J.A.M. , Doek J.E. 
Published: May 2021

De ontwikkelingen en implicaties van kinder- en mensenrechten op het gebied van klimaatverandering
Hoewel kinderen disproportioneel geraakt worden door klimaatverandering, is er tot op heden nog relatief weinig aandacht besteed aan de juridische kant hiervan. Dit artikel tracht bij te dragen door antwoord te geven op de vraag in hoeverre kinderen ‘klimaatrechten’ hebben op mensen- en kinderrechtelijk vlak. In dit kader worden de ontwikkelingen op het terrein van mensenrechten geschetst. Ook wordt ingegaan op de belangrijkste juridische implicaties van kinderrechten zoals neergelegd in het IVRK. Hiervoor zijn ook alle Concluding Observations uit 2019 op dit onderwerp bestudeerd. Bovendien wordt het analytisch rapport van de OHCHR over klimaat en kinderrechten besproken. Tot slot wordt ingegaan op de klimaatklacht die momenteel voorligt bij het VN-Kinderrechtencomité en de mogelijkheden van kinderen in Nederland voor de effectuering van hun rechten op dit vlak.
Nonthermal Crystalline Forming of Ceramic Nanoparticles by Non-Equilibrium Excitation Reaction Field of Electron
Authors: Shimoi Norihiro 
Published: May 2021

In this work, we have discovered a method of forming ZnO thin films with high mobility, high carrier density and low resistivity on plastic (PET) films using non-equilibrium reaction fields, even when the films are deposited without heating, and we have also found a thin film formation technique using a wet process that is different from conventional deposition techniques. The field emission electron-beam irradiation treatment energetically activates the surface of ZnO particles and decomposes each ZnO particles. The energy transfer between zinc ions and ZnO surface and the oxygen present in the atmosphere around the ZnO particles induce the oxidation of zinc. In addition, the ZnO thin films obtained in this study successfully possess high functional thin films with high electrical properties, including high hole mobility of 208.6 cm2/Vs, despite being on PET film substrates. These results contribute to the discovery of a mechanism to create highly functional oxide thin films using a simple two-dimensional process without any heat treatment on the substrate or during film deposition. In addition, we have elucidated the interfacial phenomena and crosslinking mechanisms that occur during the bonding of metal oxide particles, and understood the interfacial physical properties and their effects on the electronic structure. and surface/interface control, and control of higher-order functional properties in metal/ceramics/semiconductor composites, and contribute to the provision of next-generation nanodevice components in a broad sense.
From HIV to Coronavirus Disease 2019 (COVID-19)
Authors: Karcher Donald S. 
Published: May 2021

Context.—
From the onset of the human immunodeficiency virus (HIV) pandemic in the 1980s to the recent coronavirus disease 2019 (COVID-19) pandemic, multiple viral pandemics have occurred and all have been associated with hematologic complications of varying severity.

Objective.—
To review the hematologic complications associated with the HIV and other viral pandemics, the current theories regarding their causation, and the incidence and clinical impact of these complications on infected patients.

Data Sources.—
Peer-reviewed medical literature and the author's personal experience.

Conclusions.—
The HIV and other viral pandemics have been associated with a variety of hematologic complications that often cause significant morbidity and mortality in affected patients. HIV infection is associated with multiple hematologic disorders, many of which have a lower incidence in the era of highly active antiretroviral therapy but still represent a major clinical problem for HIV-infected patients. Our understanding of the pathogenesis of HIV-related hematologic complications, including HIV-associated lymphoproliferative disorders, has evolved in recent years. Other viral pandemics, including H1N1 influenza, severe acute respiratory syndrome (SARS) coronavirus, Middle East respiratory syndrome (MERS) coronavirus, and COVID-19, have also been associated with hematologic complications of varying severity. Our emerging understanding of the pathogenesis of the hematologic complications of HIV, COVID-19, and other viral pandemics may help in prevention, correct diagnosis, and treatment of these complications in current and future pandemics.
Perdón y vida pública
Authors: Esparza Daniel Ricardo , Diez Bosch Miriam 
Published: May 2021

En la sección titulada Irreversibilidad y el Poder de Perdonar en La Condición Humana, Arendt afirma que “el descubridor del papel del perdón en la esfera de los asuntos humanos fue Jesús de Nazaret”. En lo que sigue, quisiéramos aproximarnos al uso antiguo del verbo griego sungignôskô (“considerar”) que a nuestro entender cumple el mismo papel que Arendt advierte en esta supuesta novedad cristiana —la “mutua exoneración de lo que se ha hecho”—, no sólo para entender en qué consistiría el descubrimiento que Arendt atribuye a Jesús, sino porque creemos que la idea de que los griegos desconocían la facultad de perdonar es, si no falsa, al menos imprecisa.
In the section titled Irreversibility and the Power to Forgive in the Human Condition, Arendt claims that “the discoverer of the role of forgiveness in the sphere of human affairs was Jesus of Nazareth”. In what follows, we would like to approach the ancient use of the Greek verb sungignôskô (“to consider”) which, in our opinion, fulfills the same role that Arendt finds in this alleged Christian novelty —the “mutual exoneration of what has been done”— not only to understand what would the actual discovery Arendt attributes to Jesus imply, but because we believe claiming the Greeks were unaware of the faculty of forgiveness is, if not false, at least inaccurate.
Géneros naturales y definición de vida
Authors: Amilburu Martínez Alba , Soler Parra Jaime 
Published: May 2021

En el debate sobre la definición de vida algunos autores consideran que vida ha de entenderse como un género natural (Cleland y Chyba 2002, Diéguez 2013). Sin embargo, cuando se afirma que vida es un género natural se asumen también otras ideas vinculadas con la idea de género natural que conviene explicitar, tal y como han mostrado recientemente Bich y Green (2018) aunque de manera programática, y ese es precisamente el objetivo planteado aquí; mostrar cuáles son esas implicaciones y señalar las dificultades que surgen al adoptar el discurso sobre los géneros naturales para entender y analizar categorías científicas complejas como, por ejemplo, vida. En este trabajo extendemos esta crítica a las distintas formas de entender los géneros naturales y señalamos cuál es la principal causa de las dificultades que derivan de este planteamiento.
In the contemporary philosophy of biology, some authors claim that life is better undertood as a natural kind (Cleland and Chyba 2002, Diéguez 2013). This paper questions the metaphysical commitments related to the natural kind approach in relation with the debate of defining life. The goal of this paper is to show how considering life as a natural kind carries out some difficulties and costs. Those difficulties have been partialy shown by Bich and Green (2018) concerning the essentialist view of natural kinds. In this paper we extended this criticism to other ways of understanding natural kinds and we argue that such a difficulties are due to the acceptance of an inadequate frame of reference, based on a naïve idea of naturalness and on a natural/conventional dichotomy that is not properly justified.
Clima Organizacional em uma Unidade de Terapia Intensiva: percepções da equipe de enfermagem
Authors: Chiavone Flávia Barreto Tavares , Filgueira Martins Rodrigues Claúdia Cristiane , De Lima Ferreira Larissa , Candido de Oliveira Salvador Pétala Tuani , Dos Santos Bezerril Manaces , Pereira Santos Viviane Euzebia 
Published: May 2021

Objetivo: Medir el clima organizacional del equipo de enfermería en la unidad de cuidados intensivos. Método: Este es un estudio transversal, con enfoque cuantitativo, desarrollado en una unidad de cuidados intensivos de un hospital universitario en el noreste de Brasil. La recolección de datos se realizó en 2016, con la participación de 30 profesionales de enfermería. Se realizó el análisis de datos a partir de estadística descriptiva y análisis de datos bivariados. Resultados: Se encontró que los profesionales de enfermería perciben un clima organizacional bajo en el sector en que trabajan y el desarrollo profesional y los beneficios fueron el factor considerado más bajo entre los trabajadores. El análisis bivariado infiere significativamente que los profesionales que tienen hijos tienen una baja percepción del clima organizacional. Conclusión: La percepción del clima organizacional del equipo de enfermería investigado es baja.
Objective: To measure the organizational climate of the nursing team in the intensive care unit. Method: This is a cross-sectional study, with a quantitative approach, developed in the intensive care unit of a university hospital in the Northeast of Brazil. Data collection was carried out in 2016, with the participation of 30 nursing professionals. Data analysis was carried out using descriptive statistics and a bivariate analysis of data. Results: It was found that nursing professionals perceive a low organizational climate score in the sector they work. The professional Development and the benefits were considered the lowest factor by the workers. The bivariate analysis significantly infers that the professionals who have children have a low perception of the organizational climate. Conclusion: The nursing team investigated is perceives the score of the organizational climate to be low.
Objetivo: Mensurar o clima organizacional da equipe enfermagem na unidade de terapia intensiva. Método: trata-se de um estudo transversal, de abordagem quantitativa, desenvolvida em uma unidade de terapia intensiva em um hospital universitário no nordeste do Brasil. A coleta de dados foi realizada em 2016, com a participação de 30 profissionais de enfermagem. A análise dos dados se deu por estatística descritiva e análise bivariada dos dados. Resultados: Verificou-se que os profissionais de enfermagem percebem um baixo clima organizacional no setor que atuam e o Desenvolvimento profissional e benefícios foi o fator considerado mais baixo entre os trabalhadores. A análise bivariada infere de maneira significativa que os profissionais que possuem filhos têm uma baixa percepção do clima organizacional. Conclusão: A percepção do clima organizacional da equipe de enfermagem investigada é baixa.
Realidades de la práctica de la automedicación en estudiantes de la Universidad del Magdalena
Authors: Oviedo Cordoba Haidy , Cortina Navarro Carolina Elena , Osorio Coronel Javier Andres , Romero Torres Sandra Marcela 
Published: May 2021

La automedicación forma parte del autocuidado y es considerada como un recurso de salud pública primaria en el sistema de atención de la salud. Objetivo: Determinar la prevalencia y patrones de consumo que influyen en la automedicación de los estudiantes de la Universidad del Magdalena Métodos: El estudio corresponde a una investigación de carácter descriptivo, de corte transversal, y enfoque cuantitativo; la muestra se determinó por conglomerados, conformada por 312 estudiantes activos matriculados en pregrado de la Universidad del Magdalena de la ciudad de Santa Marta. Resultados: La práctica de la automedicación se vio reflejado en un 97%; los motivos por los cuales se automedican los estudiantes tienen relación con la aparición de síntomas tales como el dolor y síntomas gripales, los cuales son tratados a partir del consumo de medicamentos tipo analgésicos, antiinflamatorios, con una prevalencia del 84,26%. El principal motivo para automedicarse se relaciona con la levedad de los sintomas; el consejo de familiares en un 46,87% refleja su fuente de información; existe influencia por la publicidad especialmente televisión e internet; finalmente el 71% tiene conocimiento de las consecuencias que acarrea el automedicarse.Conclusiones: La práctica de la automedicación en la población universitaria es alta; los factores influyentes se relacionan con aparición de sintomas, el consejo de familiares, la influencia de la publicidad, la levedad de los sintomas y la falta de tiempo para visitar al médico.
Self-medication is part f self-care and is considered as a primary public health resource in the health care system. Objective: To determine the prevalence and consumption patterns that influence the automation of the students of the Universidad del Magdalena. Methods: The study corresponds to a descriptive cross-sectional and quantitative approach investigation; the sample was determined by conglomerates, made up of 312 active students enrolled in undergraduate studies at the Universidad del Magdalena the city of the Santa Marta. Results: The practice of self-medication was reflected in 97%; the reasons for which the students self-medicate are related to the appearance of symptoms stories, such as pain and flu-like symptoms, which are treated from the consumption at analgesic, anti-inflammatory drugs with prevalence of 84,26%.The main reason for self-medication is related to the mildness of the symptoms; the council of relatives in 46,87% reflects their source of information; there is influence by advertising especially television and internet; finally 71% are aware of the consequences of self -medication. Conclusions: The practice of self-medication in the University population is high; influencing factors are related to the appearance of symptoms the advice of relatives, the influence of advertising the mildness of symptoms and lack of the time to visit the doctor.
Enjeux et perspectives de la reconnaissance faciale en sciences criminelles
Authors: Jacquet1 Maëlig , Grossrieder Lionel 
Published: May 2021

L’objectif de cet article est de cristalliser de manière pragmatique les enjeux et perspectives de la reconnaissance faciale en sciences criminelles pour acquérir une meilleure connaissance des limitations et des opportunités offertes par ces technologies, essentielles à leur application au sein du système judiciaire. Nous postulons que cette réflexion doit s’inscrire dans une approche interdisciplinaire qui intègre l’utilisation d’algorithmes en considérant les spécificités de la criminologie et de la science forensique. Cet éclairage permet d’établir un bilan de l’utilisation de la reconnaissance faciale en le scindant en questions fondamentales. Quelles sont les images utilisées en reconnaissance faciale ? Comment sont-elles comparées ? Quels objectifs la reconnaissance faciale sert-elle ? Où est-elle mise en oeuvre et par quels acteurs ? Cette subdivision permet de mieux situer les enjeux et limites de la reconnaissance faciale, ainsi que les perspectives de développement et de recherche. Sur le plan des données elles-mêmes, l’enjeu principal concerne leur qualité originale puis sa dégradation potentielle aux stades de collecte et de sauvegarde des images, qui influencent leur utilisation ultérieure. Pour ce qui est des méthodes, les enjeux se cristallisent autour du manque de standardisation et de transparence, aussi bien lors de tâches exécutées par l’être humain que par un système automatique. Concernant les objectifs des tâches de reconnaissance faciale dans les domaines civil et judiciaire, les enjeux gravitent autour de la protection de la sphère privée et des libertés individuelles. Enfin, les principaux défis soulevés par son utilisation comme moyen de preuve au tribunal concernent la communication, ainsi que la standardisation et la validation méthodologique.
Comprehensive analysis based on DNA methylation and RNA-seq reveals hypermethylation of the up-regulated WT1 gene with potential mechanisms in PAM50 subtypes of breast cancer
Authors: Ren Chongyang , Tang Xiaojiang , Lan Haitao 
Published: May 2021

Background
Breast cancer (BC), one of the most widespread cancers worldwide, caused the deaths of more than 600,000 women in 2018, accounting for about 15% of all cancer-associated deaths in women that year. In this study, we aimed to discover potential prognostic biomarkers and explore their molecular mechanisms in different BC subtypes using DNA methylation and RNA-seq.

Methods
We downloaded the DNA methylation datasets and the RNA expression profiles of primary tissues of the four BC molecular subtypes (luminal A, luminal B, basal-like, and HER2-enriched), as well as the survival information from The Cancer Genome Atlas (TCGA). The highly expressed and hypermethylated genes across all the four subtypes were screened. We examined the methylation sites and the downstream co-expressed genes of the selected genes and validated their prognostic value using a different dataset (GSE20685). For selected transcription factors, the downstream genes were predicted based on the Gene Transcription Regulation Database (GTRD). The tumor microenvironment was also evaluated based on the TCGA dataset.

Results
We found that Wilms tumor gene 1 (WT1), a transcription factor, was highly expressed and hypermethylated in all the four BC subtypes. All the WT1 methylation sites exhibited hypermethylation. The methylation levels of the TSS200 and 1stExon regions were negatively correlated with WT1 expression in two BC subtypes, while that of the gene body region was positively associated with WT1 expression in three BC subtypes. Patients with low WT1 expression had better overall survival (OS). Five genes including COL11A1, GFAP, FGF5, CD300LG, and IGFL2 were predicted as the downstream genes of WT1. Those five genes were dysregulated in the four BC subtypes. Patients with a favorable 6-gene signature (low expression of WT1 and its five predicted downstream genes) exhibited better OS than that with an unfavorable 6-gene signature. We also found a correlation between WT1 and tamoxifen using STITCH. Higher infiltration rates of CD8 T cells, plasma cells, and monocytes were found in the lower quartile WT1 group and the favorable 6-gene signature group. In conclusion, we demonstrated that WT1 is hypermethylated and up-regulated in the four BC molecular subtypes and a 6-gene signature may predict BC prognosis.
Whey Protein Supplement: An Exclusive Food or Need of the Hour: Review
Authors: Sangwan Sonia , Seth Raman 
Published: May 2021

Background: Protein is an essential portion of food that exerts beneficial effects on body composition and metabolism. However, protein-rich foods are costly and scarcely available in developing countries, and protein deficiency is a significant public health concern. In this situation, searching for additional dietary protein sources is of utmost importance due to decreasing resources because of the growing global population. The current literature review is about whey protein as it is the cheapest, readily available protein source.
Methods: Milk is formed of two proteins, casein and whey. Whey is different from the casein in milk and is formed as a by-product of the cheese-making process. Whey (the liquid left after milk curdling) was deemed a waste by the dairy industry for decades. However, it is the cheapest protein source for the poor growing populations in developing countries. Whey protein is a complete protein as it contains all nine essential amino acids. It is low in lactose content.
Conclusion: Human body cannot make essential amino acids, so it is necessary to get enough of them from the diet. Due to the availability of carbohydrates, fat, immunoglobulins, lactose, and minerals, including essential amino acids in whey protein, it is necessary for human energy. There are many benefits related to whey protein consumption, such as muscle building and loss of fat. New possible therapeutic properties of whey protein have to be investigated further for the full utility to humans.