bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three dimension printing talar prostheses for total replacement in talar necrosis and collapse
Authors: Mu Mi duo , Yang Qian dong , Chen Wan , Tao Xu , Zhang Cheng ke , Zhang Xuan , Xie Mei ming , Tang Kang lai 
Published: March 2021

Abstract
Background
Reconstructing bone structures and stabilizing adjacent joints are clinical challenges in treating talar necrosis and collapse (TNC). 3D printing technology has been demonstrated to improve the accuracy of talar replacement. This study aimed to evaluate anatomical talar replacement and the clinical results.

Methods
Nine patients with TNC were enrolled between 2016 and 2020. The prosthetic shape and size were designed by CT post-processing and mirror symmetry technology. The clinical outcomes included radiographic parameters of the forefoot, hindfoot, and ankle alignment, ankle activity, recurrent pain, and peri-operative complications.

Results
After a mean follow-up of 23.17 ± 6.65 months, degenerative arthritis and prosthetic dislocation and other complications were not observed on plain radiographs. Each 3D-printed talar prosthesis was placed in the original anatomical position. The parameters which have significant changes pre-operative and post-operative are as follows: talar height, 27.59 ± 5.99 mm and 34.56 ± 3.54 mm (95% CI − 13.05 to − 0.87, t = 2.94, P = 0.032) and Meary’s angle, 11.73 ± 4.79° and 4.45 ± 1.82° (95% CI 1.29~22.44, t = 2.89, P = 0.034). The AOFAS hindfoot score improved from 26.33 ± 6.62 to 79.67 ± 3.14 at the final follow-up (95% CI 43.36~63.30, t = 13.75, P = 0.000). The VAS score decreased from 6.33 ± 1.03 to 0.83 ± 0.75 (95% CI 4.40~6.60, t = 12.84, P = 0.000). The post-operative satisfaction scores regarding pain relief, activities of daily living, and return to recreational activities were good to excellent, and the change of activity range was statistically significant.

Conclusions
The 3D printing patient-specific total talar prostheses allowed anatomical reconstruction in TNC. This novel treatment with 3D-printed prostheses could serve as a reliable patient-specific alternative in TNC.
Evaluation of trends in extreme temperatures simulated by HighResMIP models across Europe
Authors: Squintu Antonello A. , van der Schrier Gerard , van den Besselaar Else , van der Linden Eveline , Putrasahan Dian , Roberts Christopher , Roberts Malcolm , Scoccimarro Enrico , Senan Retish , Klein Tank Albert 
Published: March 2021

AbstractSimulation of past climate is an important tool for the validation of climate models. The comparison with observed daily values allows us to assess the reliability of their projections on climatic extremes in a future climate. The frequency and amplitude of extreme events are fundamental aspects that climate simulations need to reproduce as they have high impacts on economy and society. The ability to simulate them will help policy makers in taking better measures to face climate change. This work aims at evaluating how six models within the High Resolution Model Intercomparison Project reproduce the trends on extreme indices as they have been observed over Europe in the 1970–2014 period. Observed values are provided by the new homogenized version of the E-OBS gridded dataset. The comparison is performed through the use of indices based on seasonal averages and on exceedances of percentile-based thresholds, focusing on six subregions. Winter-average minimum temperature is generally underestimated by models (down to − 4 °C difference over Italy and Norway) while simulated trends in seasonal averages and extreme values are found to be too cold on Eastern Europe and too warm on Iberia and Southern Europe (e.g. up to a difference of − 4% per decade on the number of Cold Nights over Spain). On the other hand the models tend to overestimate summer maximum temperatures averages in the Mediterranean Area (up to + 5 °C over the Balkans) and underestimate these at higher latitudes. Iberia, Southern and Eastern Europe are simulated with too low trends in average summer temperatures. The simulated trends are too strong on the North West part and too weak on the South East part of Europe (down to − 3%/decade on the number of Warm Days over Italy and Western Balkans). These results corroborate the findings of previous studies about the underestimation of the warming trends of summer temperatures in Southern Europe, where these are more intense and have more impacts. The high-resolution versions of the models are compared to their lower-resolution counterparts, similar to those used in the CMIP5, showing a slight improvement for the simulation of extreme winter minimum temperatures, while no significant progresses have been found for extreme summer maximum temperatures.
Experimental prototyping of the adhesion braking control system design concept for a mechatronic bogie
Authors: Shrestha Sundar , Spiryagin Maksym , Wu Qing 
Published: March 2021

AbstractThe dynamic parameters of a roller rig vary as the adhesion level changes. The change in dynamics parameters needs to be analysed to estimate the adhesion level. One of these parameters is noise emanating from wheel–rail interaction. Most previous wheel–rail noise analysis has been conducted to mitigate those noises. However, in this paper, the noise is analysed to estimate the adhesion condition at the wheel–rail contact interface in combination with the other methodologies applied for this purpose. The adhesion level changes with changes in operational and environmental factors. To accurately estimate the adhesion level, the influence of those factors is included in this study. The testing and verification of the methodology required an accurate test prototype of the roller rig. In general, such testing and verification involve complex experimental works required by the intricate nature of the adhesion process and the integration of the different subsystems (i.e. controller, traction, braking). To this end, a new reduced-scale roller rig is developed to study the adhesion between wheel and rail roller contact. The various stages involved in the development of such a complex mechatronics system are described in this paper. Furthermore, the proposed brake control system was validated using the test rig under various adhesion conditions. The results indicate that the proposed brake controller has achieved a shorter stopping distance as compared to the conventional brake controller, and the brake control algorithm was able to maintain the operational condition even at the abrupt changes in adhesion condition.
Verwendung des Nordischen Fragebogens zu Muskel-Skelett-Beschwerden
Authors: Kreis Lotte , Liebers Falk , Dulon Madeleine , Freitag Sonja , Latza Ute 
Published: March 2021

ZusammenfassungHintergrundDie Prävalenzerhebung von Muskel-Skelett-Beschwerden im betrieblichen Kontext basiert oft auf dem Nordischen Fragebogen (NMQ) von Kuorinka et al. (1987). Derzeit existiert keine einheitliche deutschsprachige, validierte Übersetzung, zudem weist die Originalversion Unstimmigkeiten auf. Vor dem Hintergrund, dass entsprechend der Verordnung zur arbeitsmedizinischen Vorsorge (ArbMedVV) bei Belastungen des Muskel-Skelett-Systems arbeitsmedizinische Vorsorge angeboten werden muss, besteht Bedarf, eine deutsche Version des NMQ zu erarbeiten und zu validieren.ZielAnliegen der Arbeit ist die Analyse des Ist-Zustands, wie der NMQ in internationalen Studien derzeit eingesetzt wird. Anforderungen für eine deutschsprachige Version des NMQ sind daraus abzuleiten.Material und MethodenDurchgeführt wurde ein narratives Review. Recherchiert wurde in der Datenbank PubMed nach Studien, in denen der NMQ zur Erhebung der Prävalenz von Muskel-Skelett-Beschwerden bei Personen im erwerbsfähigen Alter eingesetzt wurde. Die Ergebniszusammenfassung ist deskriptiv.ErgebnisseEs wurden 132 Publikationen identifiziert. Mehrheitlich wurde eine modifizierte Version des NMQ verwendet. Am häufigsten wurde die 12-Monats- und 7‑Tages-Prävalenz erhoben. Die Beschwerdeprävalenz von Schulter‑, Ellenbogen- und Handgelenken sowie des Nackens und unteren Rückens wurde am häufigsten erfragt. Modifikationen erfolgten insbesondere hinsichtlich der Abfragelogik sowie bei den zu untersuchenden Körperregionen.DiskussionDer NMQ ist ein international vielgenutztes Instrument, das mehrheitlich an die jeweiligen Erfordernisse des Untersuchungskontextes angepasst wird. Eine Neuformulierung des NMQ sollte kurz und modular sein, eine einfache Abfragelogik enthalten und sowohl in betriebsepidemiologischen Studien als auch in der arbeitsmedizinischen Vorsorge anwendbar sein.
Water quality assessment of Loktak Lake, Northeast India using 2-D hydrodynamic modelling
Authors: Khwairakpam Eliza , Khosa Rakesh , Gosain Ashvani , Nema Arvind 
Published: March 2021

AbstractThe paper comprises of an application of a multi-faceted physically based two-dimensional (2D) hydrodynamic model to simulate the transport phenomena of Loktak Lake, including the water quality of Loktak Lake, for which there is consensus that it is deteriorating due to river discharge from sub-catchments carrying sewage loads, soil sediments and agricultural fertilizers, and therefore, has emerged as a serious environmental concern. Accordingly, the study attempts to understand the overall environmental quality of the Loktak system and in particular simulate Loktak Lake water quality (state) variables by coupling through MIKE 21 ECO Lab. The model simulated dissolved oxygen and biochemical oxygen demand throughout the lake.
ROBUST ESTIMATION OF LOSS MODELS FOR LOGNORMAL INSURANCE PAYMENT SEVERITY DATA
Authors: Poudyal Chudamani 
Published: March 2021

AbstractThe primary objective of this scholarly work is to develop two estimation procedures – maximum likelihood estimator (MLE) and method of trimmed moments (MTM) – for the mean and variance of lognormal insurance payment severity data sets affected by different loss control mechanism, for example, truncation (due to deductibles), censoring (due to policy limits), and scaling (due to coinsurance proportions), in insurance and financial industries. Maximum likelihood estimating equations for both payment-per-payment and payment-per-loss data sets are derived which can be solved readily by any existing iterative numerical methods. The asymptotic distributions of those estimators are established via Fisher information matrices. Further, with a goal of balancing efficiency and robustness and to remove point masses at certain data points, we develop a dynamic MTM estimation procedures for lognormal claim severity models for the above-mentioned transformed data scenarios. The asymptotic distributional properties and the comparison with the corresponding MLEs of those MTM estimators are established along with extensive simulation studies. Purely for illustrative purpose, numerical examples for 1500 US indemnity losses are provided which illustrate the practical performance of the established results in this paper.
Do applications of systemic herbicides when green fruit are present prevent seed production or viability of garlic mustard (Alliaria petiolata)?
Authors: Roth Leo , Dias José Luiz C. S. , Evans Christopher , Rohling Kevin , Renz Mark 
Published: March 2021

AbstractGarlic mustard [Alliaria petiolata (M. Bieb.) Cavara & Grande] is a biennial invasive plant commonly found in the northeastern and midwestern United States. Although it is not recommended to apply herbicides after flowering, land managers frequently desire to conduct management during this timing. We applied glyphosate and triclopyr (3% v/v and 1% v/v using 31.8% and 39.8% acid equivalent formulations, respectively) POST to established, second-year A. petiolata populations at three locations when petals were dehiscing and evaluated control, seed production, and seed viability. POST glyphosate applications at this timing provided 100% control of A. petiolata by 4 wk after treatment at all locations, whereas triclopyr efficacy was variable, providing 38% to 62% control. Seed production was only reduced at one location, with similar results regardless of treatment. Percent seed viability was also reduced, and when combined with reductions in seed production, resulted in a 71% to 99% reduction in number of viable seeds produced per plant regardless of treatment. While applications did not eliminate viable seed production, our findings indicate that glyphosate and triclopyr applied while petals are dehiscing is a viable alternative to cutting or hand pulling at this timing, as it substantially decreased viable A. petiolata seed production.
Seasonal paleoecological records from antler collagen δ13C and δ15N
Authors: Schwartz-Narbonne Rachel , Plint Tessa , Hall Elizabeth , Zazula Grant , Longstaffe Fred J. 
Published: March 2021

AbstractCervids living in high latitudes have evolved to thrive in ecosystems that experience dramatic seasonal changes. Understanding these seasonal adaptations is important for reconstructing cervid life histories, ecosystem dynamics, and responses in the distant and not-so-distant past to changing seasonality caused by climate change. Cervid antlers provide a rare opportunity for insight into faunal seasonal ecology, as they are grown and shed each year. Stable isotopes of carbon and nitrogen measured directly from antlers have the potential to provide seasonal dietary data for individuals. If the isotopic signals in bone and antler are controlled by the same metabolic processes, then the stable carbon and nitrogen isotope compositions of collagen (δ13CColland δ15NColl) from incrementally grown antler tissue provide time-constrained dietary signals from the spring and summer growth season. Bone, by comparison, provides an average signal over several years. The amino acid (glutamate and phenylalanine) δ15N in antlers from modern captive caribou showed similar trophic discrimination factors to earlier results for other collagenous tissues (bone, tooth dentin, and cementum). Hence, growth rate was not the primary control on the stable isotope composition of antler collagen. We applied this knowledge to assess seasonal shifts in Quaternary fossils of three Cervidae species: elk (Cervus elaphus), moose (Alces alces), and caribou (Rangifer tarandus). Paired antler–bone δ13CColland δ15NCollfrom the same individual were used to identify differences between summer and annual diet and ecology. Intra-antler isotopic variability from serially sampled antlers was used to examine seasonal dietary shifts and specialization.
Aphid alarm pheromone alters larval behaviour of the predatory gall midge, Aphidoletes aphidimyza and decreases intraguild predation by anthocorid bug, Orius laevigatus
Authors: Hosseini Mojtaba , Mehrparvar Mohsen , Zytynska Sharon E. , Hatano Eduardo , Weisser Wolfgang W. 
Published: March 2021

AbstractIntraguild predation is the killing and consuming of a heterospecific competitor that uses similar resources as the prey, and also benefit from preying on each other. We investigated the foraging behaviour of the gallmidge, Aphidoletes aphidimyza, a predator of aphids used for biological control that is also the intraguild prey for most other aphid natural enemies. We focus on how aphid alarm pheromone can alter the behaviour of the gallmidge, and predation by the anthocorid bug Orius laevigatus (O. laevigatus). We hypothesised that gallmidges would respond to the presence of (E)-β-farnesene (EBF) by leaving the host plant. Since feeding by Aphidoletes gallmidge larvae does not induce EBF emission by aphids, this emission indicates the presence of an intraguild predator. We found that gallmidge larvae reduced their foraging activities and left the plant earlier when exposed to EBF, particularly when aphids were also present. Contrastingly, gallmidge females did not change the time visiting plants when exposed to EBF, but lay more eggs on plants that had a higher aphid density. Lastly, EBF reduced the number of attacks of the intraguild predator, O. laevigatus, on gallmidge larvae, potentially because more gallmidges stopped aphid feeding and moved off the plant at which point O. laevigatus predated on aphids. Our work highlights the importance of understanding how intraguild predation can influence the behaviour of potential biological control agents and the impact on pest control services when other natural enemies are also present.
Non-steroid, non-antibiotic anti-biofilm therapy for the treatment of chronic rhinosinusitis: a systematic review
Authors: Taylor A , Fuzi J , Sideris A , Banks C , Havas T E 
Published: March 2021

AbstractObjectiveChronic rhinosinusitis patients with biofilms cultured from their sinonasal cavity have greater symptom burden and risk of recalcitrant disease. A number of non-antibiotic, ‘anti-biofilm’ treatments exist which show anti-biofilm properties in preclinical studies. There is little evidence evaluating their impact on clinical symptom scores in chronic rhinosinusitis.MethodA systematic review was performed to assess the literature regarding the efficacy of non-steroid, non-antibiotic, anti-biofilm specific topical therapies in the treatment of chronic rhinosinusitis. The primary outcome assessed was change in validated patient reported outcome measures before and after anti-biofilm treatment.ResultsThirteen studies assessing the effect of anti-biofilm therapies in chronic rhinosinusitis through validated patient-reported outcome measures were included. Seven different anti-biofilm specific therapies for chronic rhinosinusitis were identified. None of the seven anti-biofilm therapies was identified as being confidently efficacious beyond placebo. Only one therapy (intranasal xylitol) showed a statistically significant reduction in symptom scores compared with placebo in more than one trial.ConclusionRobust evidence supporting the use of various anti-biofilm therapies in chronic rhinosinusitis is lacking. Further high quality, human, in vivo trials studying the effect of anti-biofilm therapies in chronic rhinosinusitis are needed to address the deficiencies of the current evidence base.
An improved nonlinear innovation-based parameter identification algorithm for ship models
Authors: Zhao Baigang , Zhang Xianku 
Published: March 2021

AbstractTo solve the problem of identifying ship model parameters quickly and accurately with the least test data, this paper proposes a nonlinear innovation parameter identification algorithm for ship models. This is based on a nonlinear arc tangent function that can process innovations on the basis of an original stochastic gradient algorithm. A simulation was carried out on the ship Yu Peng using 26 sets of test data to compare the parameter identification capability of a least square algorithm, the original stochastic gradient algorithm and the improved stochastic gradient algorithm. The results indicate that the improved algorithm enhances the accuracy of the parameter identification by about 12% when compared with the least squares algorithm. The effectiveness of the algorithm was further verified by a simulation of the ship Yu Kun. The results confirm the algorithm's capacity to rapidly produce highly accurate parameter identification on the basis of relatively small datasets. The approach can be extended to other parameter identification systems where only a small amount of test data is available.
Predicting chromosome damage in astronauts participating in international space station missions
Authors: Feiveson Alan , George Kerry , Shavers Mark , Moreno-Villanueva Maria , Zhang Ye , Babiak-Vazquez Adriana , Crucian Brian , Semones Edward , Wu Honglu 
Published: March 2021

AbstractSpace radiation consists of energetic protons and other heavier ions. During the International Space Station program, chromosome aberrations in lymphocytes of astronauts have been analyzed to estimate received biological doses of space radiation. More specifically, pre-flight blood samples were exposed ex vivo to varying doses of gamma rays, while post-flight blood samples were collected shortly and several months after landing. Here, in a study of 43 crew-missions, we investigated whether individual radiosensitivity, as determined by the ex vivo dose–response of the pre-flight chromosome aberration rate (CAR), contributes to the prediction of the post-flight CAR incurred from the radiation exposure during missions. Random-effects Poisson regression was used to estimate subject-specific radiosensitivities from the preflight dose–response data, which were in turn used to predict post-flight CAR and subject-specific relative biological effectiveness (RBEs) between space radiation and gamma radiation. Covariates age, gender were also considered. Results indicate that there is predictive value in background CAR as well as radiosensitivity determined preflight for explaining individual differences in post-flight CAR over and above that which could be explained by BFO dose alone. The in vivo RBE for space radiation was estimated to be approximately 3 relative to the ex vivo dose response to gamma irradiation. In addition, pre-flight radiosensitivity tended to be higher for individuals having a higher background CAR, suggesting that individuals with greater radiosensitivity can be more sensitive to other environmental stressors encountered in daily life. We also noted that both background CAR and radiosensitivity tend to increase with age, although both are highly variable. Finally, we observed no significant difference between the observed CAR shortly after mission and at > 6 months post-mission.
Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory
Authors: Stahlhut Maike , Ha Teng Cheong , Takmakova Ekaterina , Morgan Michael A. , Schwarzer Adrian , Schaudien Dirk , Eder Matthias , Schambach Axel , Kustikova Olga S. 
Published: March 2021

AbstractRegulation of haematopoietic stem cell fate through conditional gene expression could improve understanding of healthy haematopoietic and leukaemia initiating cell (LIC) biology. We established conditionally immortalised myeloid progenitor cell lines co-expressing constitutive Hoxa9.EGFP and inducible Meis1.dTomato (H9M-ciMP) to study growth behaviour, immunophenotype and morphology under different cytokine/microenvironmental conditions ex vivo upon doxycycline (DOX) induction or removal. The vector design and drug-dependent selection approach identified new retroviral insertion (RVI) sites that potentially collaborate with Meis1/Hoxa9 and define H9M-ciMP fate. For most cell lines, myelomonocytic conditions supported reversible H9M-ciMP differentiation into neutrophils and macrophages with DOX-dependent modulation of Hoxa9/Meis1 and CD11b/Gr-1 expression. Here, up-regulation of Meis1/Hoxa9 promoted reconstitution of exponential expansion of immature H9M-ciMPs after DOX reapplication. Stem cell maintaining conditions supported selective H9M-ciMP exponential growth. H9M-ciMPs that had Ninj2 RVI and were cultured under myelomonocytic or stem cell maintaining conditions revealed the development of DOX-dependent acute myeloid leukaemia in a murine transplantation model. Transcriptional dysregulation of Ninj2 and distal genes surrounding RVI (Rad52, Kdm5a) was detected. All studied H9M-ciMPs demonstrated adaptation to T-lymphoid microenvironmental conditions while maintaining immature myelomonocytic features. Thus, the established system is relevant to leukaemia and stem cell biology.