bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychosexual Morbidity in Women With Ovarian Cancer: Evaluation by Germline BRCA Gene Mutational Status
Authors: Logue Chloe A. , Pugh Julia , Foden Philip , Mahmood Reem D. , Morgan Robert D. , Mitchell Claire , Hasan Jurjees , Clamp Andrew R. , Jayson Gordon C. 
Published: December 2021

Abstract

Introduction
Up to 75% of women with ovarian cancer experience psychosexual morbidity and approximately 15–20% of women with ovarian cancer have a germline BRCA1/2 mutation (gBRCAm). However, psychosexual morbidity remains unexplored in women with gBRCAm ovarian cancer.

Aim
Given their younger age, genetic diagnosis, breast cancer risk, and increased prevalence of surgically-induced menopause, we aim to assess whether women with gBRCAm ovarian cancer experience distinct psychosexual morbidity.

Methods
Psychosexual morbidity was investigated in 2 cohorts of women with ovarian cancer: women with gBRCAm ovarian cancer vs women with gBRCA wildtype (gBRCAwt) ovarian cancer. Between August 2019 and March 2020, women with high-grade serous carcinoma of the ovary, Fallopian tube or primary peritoneum were approached in clinic or telephoned and invited to take part. Exclusion criteria included: women with alternative histology; women admitted from clinic; and women who lacked capacity to independently complete the questionnaire. The Female Sexual Function Index (FSFI) and background information were collected at a single time-point per patient. Scores below 26.55 were interpreted to suggest psychosexual dysfunction.

Main Outcome Measure
Responses including total and domain FSFI scores, self-reported psychosexual problems and interest in psychosexual support were compared.

Results
Of 103 women approached, 53% returned questionnaires. In this exploratory analysis, women with gBRCAm ovarian cancer were significantly younger (51–60 years vs 61–70 years, gBRCAwt, P = .010). There was a trend towards increased prevalence of surgical menopause (57% vs 27%, P = .097) and breast surgery (53% vs 22%, P = .132, gBRCAm vs gBRCAwt, respectively). Women with gBRCAm ovarian cancer scored higher in the FSFI questionnaire, particularly women under 60 years (15.1 vs 2.7, P = .070), approaching significance. Women with gBRCAm ovarian cancer expressed more interest for face-to-face services (P = .018), especially psychosexual therapy (65% vs 30%) and more often felt the service was insufficient, approaching significance (71% vs 44%, gBRCAm vs gBRCAwt, respectively, P = .076).

Conclusion
Women with gBRCAm ovarian cancer are younger, express more interest for specialist psychosexual support and potentially different psychosexual problems, warranting further exploration.
Sources of exposure identified through structured interviews of healthcare workers who test positive for severe acute respiratory coronavirus virus 2 (SARS-CoV-2): A prospective analysis at two teaching hospitals
Authors: Rhee Chanu , Baker Meghan A. , Tucker Robert , Griesbach Diane , McDonald Dinah , Williams Sarah A. , Fiumara Karen , Resnick Andrew , Klompas Michael ,   for the CDC Prevention Epicenters Program
Published: December 2021

Abstract
We interviewed 1,208 healthcare workers with positive SARS-CoV-2 tests between October 2020 and June 2021 to determine likely exposure sources. Overall, 689 (57.0%) had community exposures (479 from household members), 76 (6.3%) had hospital exposures (64 from other employees including 49 despite masking), 11 (0.9%) had community and hospital exposures, and 432 (35.8%) had no identifiable source of exposure.
Gennaeocrinus tariatensis, a new Emsian (Devonian) monobathrid crinoid from the Tarvagatay Terrane of Mongolia
Authors: Waters Johnny A. , Ausich William I. 
Published: December 2021

AbstractGennaeocrinus tariatensis new species is an Emsian (Devonian) monobathrid crinoid described from the Tarvagatay Terrane of Mongolia and part of the Central Asian Orogenic Belt. The Tarvagatay Terrane is an arc terrane that accreted to the southern margin of the Siberian Craton. Gennaeocrinus tariatensis was collected from the Emsian Tariat Formation, a terrigenous sequence of conglomerates, sandstones, and siltstones. Associated faunas include brachiopods, molluscs, and rare tabulate corals. Although Gennaeocrinus is well known from the Emsian–Givetian of North America, this is the first occurrence of the genus outside Laurussia. Mongolia is a large country with many terranes having varied paleogeographic, sedimentological, and tectonic histories; but reports of Paleozoic echinoderms are rare. The crinoid occurrence from the Tariat Formation is from the same age as previously described Emsian crinoids from the Chuluum Formation but differs significantly in sedimentology, paleogeography, and paleolatitude.UUID: http://zoobank.org/d87cb083-4360-41e5-ac90-1b8ef625a31d
Numerosities are not ersatz numbers
Authors: Dutilh Novaes Catarina , dos Santos César Frederico 
Published: December 2021

Abstract
In describing numerosity as “a kind of ersatz number,” Clarke and Beck fail to consider a familiar and compelling definition of numerosity, which conceptualizes numerosity as the cognitive counterpart of the mathematical concept of cardinality; numerosity is the magnitude, whereas number is a scale through which numerosity/cardinality is measured. We argue that these distinctions should be considered.
Numerosity, area-osity, object-osity? Oh my
Authors: Yousif Sami R. 
Published: December 2021

Abstract
There is ongoing debate about whether number is perceived directly. Clarke and Beck suggest that what plagues this debate is a lack of shared understanding about what it means to perceive number in the first place. I agree. I argue that the perception of number is held to a different standard than, say, the perception of objecthood; considering this, I explore what it might mean for the number system to represent rational numbers.
Phonological characteristics of novel gesture production in children with developmental language disorder: Longitudinal findings
Authors: Factor Laiah , Goffman Lisa 
Published: December 2021

AbstractChildren with developmental language disorder (DLD; aka specific language impairment) are characterized based on deficits in language, especially morphosyntax, in the absence of other explanatory conditions. However, deficits in speech production, as well as fine and gross motor skill, have also been observed, implicating both the linguistic and motor systems. Situated at the intersection of these domains, and providing insight into both, is manual gesture. In the current work, we asked whether children with DLD showed phonological deficits in the production of novel gestures and whether gesture production at 4 years of age is related to language and motor outcomes two years later. Twenty-eight children (14 with DLD) participated in a two-year longitudinal novel gesture production study. At the first and final time points, language and fine motor skills were measured and gestures were analyzed for phonological feature accuracy, including handshape, path, and orientation. Results indicated that, while early deficits in phonological accuracy did not persist for children with DLD, all children struggled with orientation while handshape was the most accurate. Early handshape and orientation accuracy were also predictive of later language skill, but only for the children with DLD. Theoretical and clinical implications of these findings are discussed.
Reply to My Critics
Authors: Stilz Anna 
Published: December 2021

AbstractThis essay replies to three critics of my book Territorial Sovereignty: A Philosophical Exploration. First, in response to Kit Wellman, I defend the claim that states sometimes have a right against external interference even when their decisions depart from the requirements of social justice. This “right to do wrong” is grounded in respect for a legitimate procedure of collective self-determination, in which the state's members have an important interest. Second, I reply to Michael Blake's concern that there is an inconsistency in my treatment of people's actual wills in politics. I clarify that my view places weight on the actual wills only of “cooperators” (a technical term), and that cooperators’ actual wills matter because they have claims against alien rule. There is no inconsistency in treating political annexation differently from immigration since immigrants rarely threaten to impose alien rule on cooperators. Finally, I address Adom Getachew's concerns about the imperial dimensions of the states system, arguing that my book contains resources for theorizing remedial claims to land in settler colonial societies and other reparative duties of global justice.
Exploring Western North Pacific Tropical Cyclone Activity in the High‐Resolution Community Atmosphere Model
Authors: Wu Xiaoning , Reed Kevin A. , Callaghan Patrick , Bacmeister Julio T. 
Published: December 2021

AbstractHigh‐resolution climate models (∼28 km grid spacing) can permit realistic simulations of tropical cyclones (TCs), thus enabling their investigation in relation to the climate system. On the global scale, previous works have demonstrated that the Community Atmosphere Model (CAM) version 5 presents a reasonable TC climatology under prescribed present‐day (1980–2005) forcing. However, for the Western North Pacific (WNP) region, known biases in simulated TC genesis frequency and location under‐represent the basin's dominant share in observations. This study addresses these model biases in WNP by evaluating WNP TCs in a decadal simulation, and exploring potential improvements through nudging experiments. Among the major environmental controls of TC genesis, the lack of mid‐level moisture is identified as the leading cause of the deficit in simulated WNP TC genesis over the Pacific Warm Pool. Subsequent seasonal experiments explore the effect of constraining the large‐scale environment on TC development by nudging WNP temperature field toward reanalysis at various strengths. Temperature nudging elicits a significant response in TC genesis and intensity development, as well as in moisture and convection over the Warm Pool. These responses are sensitive to the choice of nudging timescale. Overall, the nudging experiments demonstrate that improvements in the large‐scale environment can lead to improvements in simulated TCs, suggesting future model developments in relation to model physics. In this way, the potential improvements in model fidelity will contribute to the understanding of how the mean state of current or future climates may give rise to extremes such as TCs.
Eruca sativa seed napin structural insights and thorough functional characterization
Authors: Khaliq Binish , Falke Sven , Saeed Qamar , Bilal Muhammad , Munawar Aisha , Ali Arslan , Baermann Gunnar , Athar Habib-ur-Rehman , Mahmood Seema , Betzel Christian , Ali Qurban , Akrem Ahmed 
Published: December 2021

AbstractA potent napin protein has been thoroughly characterized from seeds of rocket salad (Eruca sativa). Eruca sativa napin (EsNap) was purified by ammonium sulfate precipitation (70%) and size-exclusion chromatography. Single intact 16 kDa EsNap band was reduced to 11 and 5 kDa bands respectively on SDS-PAGE. Nano LC–MS/MS yielded two fragments comprising of 26 residues which showed 100% sequence identity with napin-3 of Brassica napus. CD spectroscopy indicated a dominant α-helical structure of EsNap. Monodispersity of EsNap was verified by dynamic light scattering, which also confirmed the monomeric status with a corresponding hydrodynamic radius of 2.4 ± 0.2 nm. An elongated ab initio shape of EsNap was calculated based on SAXS data, with an Rg of 1.96 ± 0.1 nm. The ab initio model calculated by DAMMIF with P1 symmetry and a volume of approx. 31,100 nm3, which corresponded to a molecular weight of approximately 15.5 kDa. The comparison of the SAXS and ab initio modeling showed a minimized χ2-value of 1.87, confirming a similar molecular structure. A homology model was predicted using the coordinate information of Brassica napus rproBnIb (PDB ID: 1SM7). EsNap exhibited strong antifungal activity by significantly inhibiting the growth of Fusarium graminearum. EsNap also showed cytotoxicity against the hepatic cell line Huh7 and the obtained IC50 value was 20.49 µM. Further, strong entomotoxic activity was experienced against different life stages of stored grain insect pest T. castaneum. The result of this study shows insights that can be used in developing potential antifungal, anti-cancerous and insect resistance agents in the future using EsNap from E. sativa.
The Edible Plant Microbiome represents a diverse genetic reservoir with functional potential in the human host
Authors: Soto-Giron Maria J. , Kim Ji-Nu , Schott Eric , Tahmin Claudine , Ishoey Thomas , Mincer Tracy J. , DeWalt Jillian , Toledo Gerardo 
Published: December 2021

AbstractPlant microbiomes have been extensively studied for their agricultural relevance on growth promotion and pathogenesis, but little is known about their role as part of the diet when fresh fruits and vegetables are consumed raw. Most studies describing these communities are based on 16S rRNA gene amplicon surveys, limiting our understanding of the taxonomic resolution at the species level and functional capabilities. In this study, we characterized microbes colonizing tomatoes, spinach, brined olives, and dried figs using shotgun metagenomics. We recovered metagenome-assembled genomes of novel lactic acid bacteria from green olives and identified high intra- and inter-specific diversity of Pseudomonas in tomatoes. All samples were colonized by Pseudomonas, consistent with other reports with distinct community structure. Functional characterization showed the presence of enzymes involved in vitamin and short chain fatty acid metabolism and degradation of diverse carbohydrate substrates including plant fibers. The dominant bacterial members were isolated, sequenced, and mapped to its metagenome confirming their identity and indicating the microbiota is culturable. Our results reveal high genetic diversity, previously uncultured genera, and specific functions reflecting a likely plant host association. This study highlights the potential that plant microbes can play when consumed as part of our diet and proposes these as transient contributors to the gut microbiome.
RNAmetasome network for macromolecule biogenesis in human cells
Authors: Iuchi Shiro , Paulo Joao A. 
Published: December 2021

AbstractRNA plays a central role in macromolecule biogenesis for various pathways, such as gene expression, ribosome biogenesis, and chromatin remodeling. However, RNA must be converted from its nascent to functional forms for that role. Here, we describe a large RNA metabolic network (RNAmetasome network) for macromolecule biogenesis in human cells. In HEK293T, the network consists of proteins responsible for gene expression, splicing, ribosome biogenesis, chromatin remodeling, and cell cycle. Reciprocal immunoprecipitations show that MKI67, GNL2, MDN1, and ELMSAN1 are core proteins of the network, and knockdown of either MKI67 or GNL2 affects the state of the other protein, MDN1, and some other network members. Furthermore, GNL2 knockdown retards cell proliferation. Several proteins of the RNAmetasome network are diminished in Hela.cl1, and this diminishment is associated with low expression of MDN1 and elevated MKI67 degradation. These results together suggest that the RNAmetasome network is present in human cells and associated with proliferation, and that MKI67, GNL2, and MDN1 play an important role in organizing the RNAmetasome network.
Harnessing sensing systems towards urban sustainability transformation
Authors: Grêt-Regamey Adrienne , Switalski Michal , Fagerholm Nora , Korpilo Silviya , Juhola Sirkku , Kyttä Marketta , Käyhkö Niina , McPhearson Timon , Nollert Markus , Rinne Tiina , Soininen Niko , Toivonen Tuuli , Räsänen Aleksi , Willberg Elias , Raymond Christopher M. 
Published: December 2021

AbstractRecent years have seen a massive development of geospatial sensing systems informing the use of space. However, rarely do these sensing systems inform transformation towards urban sustainability. Drawing on four global urban case examples, we conceptualize how passive and active sensing systems should be harnessed to secure an inclusive, sustainable and resilient urban transformation. We derive principles for stakeholders highlighting the need for an iterative dialogue along a sensing loop, new modes of governance enabling direct feeding of sensed information, an account for data biases in the sensing processes and a commitment to high ethical standards, including open access data sharing.
Who is Right? A Word-Identification-in-Noise Test for Young Children Using Minimal Pair Distracters
Authors: Evans Samuel , Rosen Stuart 
Published: December 2021

Purpose:Many children have difficulties understanding speech. At present, there are few assessments that test for subtle impairments in speech perception with normative data from U.K. children. We present a new test that evaluates children's ability to identify target words in background noise by choosing between minimal pair alternatives that differ by a single articulatory phonetic feature. This task (a) is tailored to testing young children, but also readily applicable to adults; (b) has minimal memory demands; (c) adapts to the child's ability; and (d) does not require reading or verbal output.Method:We tested 155 children and young adults aged from 5 to 25 years on this new test of single word perception.Results:Speech-in-noise abilities in this particular task develop rapidly through childhood until they reach maturity at around 9 years of age.Conclusions:We make this test freely available and provide associated normative data. We hope that it will be useful to researchers and clinicians in the assessment of speech perception abilities in children who are hard of hearing or have developmental language disorder, dyslexia, or auditory processing disorder.Supplemental Material:https://doi.org/10.23641/asha.17155934
Use of Neuromuscular Electrical Stimulationfor Swallowing Habilitation in High-Risk Infants: A Survey of Clinical Practice
Authors: Bustamante Deborah Acevedo , Plumb Allison M. , Bailey Dallin J. , Sandage Mary J. 
Published: December 2021

Purpose:
The purpose of this clinical focus article was to identify clinical practice patterns of speech-language pathologists (SLPs) who use neuromuscular electrical stimulation (NMES) with the high-risk infants, specifically, the modality treatment parameters and physiological rationale.

Method:
An online survey was disseminated to query use of NMES by licensed SLPs who routinely address swallowing habilitation in high-risk infants.

Results:
Eleven of the 40 practicing SLPs who completed the survey indicated they have used NMES on neonates and infants. Most survey respondents reported not using NMES with infants. Of the SLPs who used this modality, over half reported they relied on clinical judgment for determination of NMES dose, frequency of treatments, electrode placement, and discharge determination. While SLPs acknowledged that little empirical evidence is available, those who used this modality indicated that the American Speech-Language-Hearing Association should support this modality in infants.

Conclusions:
Reliance on clinical judgment, as indicated by SLPs who use NMES on high-risk infants, is not consistent with the evidence-based practice triad, which encourages the use of high-quality peer-reviewed published evidence to inform clinical decision-making. Additional basic and applied research is needed to support use of NMES as a therapeutic modality in infants.
Sequential extraction and recognition of pulse group structure for multi‐function radar
Authors: Kang Shi‐Qian , Yuan Shuo , Wang Cong , Liu Zhang‐Meng 
Published: December 2021

AbstractThe structure design and switching regulation of pulse groups in multi‐function radars (MFRs) are closely related to the work mode. The sequential extraction and recognition of MFR pulse group structure is a fundamental task to analysing and interpreting the work modes and behaviour intentions of an MFR. In this study, the temporal structure of MFR pulse group is expressed hierarchically, which is intensively modelled based on regular grammar. Besides, a corresponding hierarchical automaton is established to sequentially extract and recognise the MFR pulse group structure in pulse train. The hierarchical automaton used for pulse group recognition has a two‐layer structure. The bottom layer of the hierarchical automaton realises the sequential input of pulses and recognition of pulse subgroups, and the sequential input of pulse subgroups and recognition of pulse groups are realised at the top layer. The simulation results demonstrate that the proposed method performs satisfyingly in recognising the pulse group structure and is robust to not only pulse noises but also to the emitter number and pulse group scale.
Schwerpunkt: Leitlinien
Authors: Kainer Franz 
Published: December 2021

Neue Empfehlungen für die evidenzbasierte Geburtshilfe
Seit 22.12.2020 gibt es mit der S3-Leitlinie „Die vaginale Geburt am Termin“ erstmals Empfehlungen zur vaginalen Geburt. Diese Leitlinie wurde federführend von der Deutschen Gesellschaft für Hebammenwissenschaft (DGHWi) und von der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG) erstellt. Es ist sehr erfreulich, dass nun neben der S3-Leitlinie zur Sectio eine weitere gemeinsame S3-Leitlinie von Hebammen und Frauenärzt*innen zur Verfügung steht.