bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal relationships among interpersonal openness trait, hostile attribution bias, and displaced aggressive behaviour: Big Five treated as covariates
Authors: Su Shu , Quan Fangying , Xia Ling‐Xiang 
Published: February 2021

Displaced aggressive behaviour is associated with many negative outcomes. Although certain personality traits predict displaced aggressive behaviour, the uniquely longitudinal effect of indigenous interpersonal traits on displaced aggressive behaviour is ignored. To address this gap, we explored the longitudinal relationship among an indigenously interpersonal trait of China (interpersonal openness), hostile attribution bias, and self‐reported displaced aggressive behaviour. Additionally, we tested whether hostile attribution bias mediated the relationship between interpersonal openness and self‐reported displaced aggressive behaviour. The Interpersonal Self‐Support Scale for Undergraduate Students, Word Sentence Association Paradigm for Hostility, Displaced Aggression Questionnaire, and the NEO Personality Inventory‐3 were administered to 942 undergraduates on two occasions, 6 months apart. A cross‐lagged model showed that, after controlling for the Big Five personality traits, interpersonal openness predicted subsequent hostile attribution bias, and hostile attribution bias predicted self‐reported displaced aggressive behaviour 6 months later. Hostile attribution bias at time 2 mediated the relationship between interpersonal openness at time 1 and self‐reported displaced aggressive behaviour at time 2. These results were consistent with the interpersonal self‐support theory's appraisals of interpersonal openness, and they extended the social information processing and general aggression models to explain displaced aggressive behaviour.
New infections and HIV‐1 subtypes among febrile persons and blood donors in Oyo State, Nigeria
Authors: Olusola Babatunde A. , Olaleye David O. , Odaibo Georgina N. 
Published: February 2021

AbstractPurposeThere were approximately 37.9 million persons infected with HIV in 2018 globally, resulting in 770,000 deaths annually. Over 50% of this infection and deaths occur in sub‐Saharan Africa, with countries like Nigeria being seriously affected. Nigeria has one of the highest rates of new infections globally. To control HIV infection in Nigeria, there is a need to continually screen high‐risk groups for early HIV infection and subtypes using very sensitive methods. In this study, new HIV‐1 infection and circulating HIV‐1 subtypes among febrile persons and blood donors were determined. Performance characteristics of three commercial EIA kits were also evaluated.MethodsIn total, 1028 participants were recruited for the study. New HIV‐1 infection and subtypes were determined using enzyme immunoassays and molecular techniques, respectively. Sensitivity, specificity, predictive values, and agreements were compared among the EIA kits using PCR‐confirmed HIV‐positive and negative samples.ResultsThe overall prevalence of HIV infection in this study was 5.35%. The rate of new HIV infection was significantly different (p < .03674) among 1028 febrile persons (Ibadan: 2.22%; Saki: 1.36%) and blood donors (5.07%) studied. Three subtypes, CRF02_AG, A, and G, were found among those with new HIV infection. Whereas the commercial ELISA kits had very high specificities (94.12%, 100%, and 100%) for HIV‐1 detection, Alere Determine HIV‐1 antibody rapid kit had the lowest sensitivity score (50%).ConclusionGenetic diversity of HIV‐1 strains among infected individuals in Oyo State, Nigeria, is still relatively high. This high level of diversity of HIV‐1 strains may impact the reliability of diagnosis of the virus in Nigeria and other African countries where many of the virus strains co‐circulate.
Review of crop‐specific tolerance limits to acidity, salinity, and sodicity for seventeen cereal, pulse, and oilseed crops common to rainfed subtropical cropping systems
Authors: Page Kathryn L. , Dang Yash P. , Martinez Cristina , Dalal Ram C. , Wehr J. Bernhard , Kopittke Peter M. , Orton Thomas G. , Menzies Neal W. 
Published: February 2021

AbstractSoil constraints limit crop water and nutrient extraction and lead to yield loss globally. In rainfed agriculture, the selection of crop species more likely to yield well under constrained conditions is an important management tool. However, information on the most appropriate crops is often difficult to access due to its publication in a wide range of disparate sources and the various measures of crop tolerance used. This study aimed to improve our ability to identify crops for constrained areas in rainfed subtropical cropping systems by compiling published information that had assessed the grain yield response to acidic, saline, or sodic conditions of 17 cereal, pulse, and oilseed crops. This information was used to develop a 'traffic light' system for salinity and acidity to provide guidance on when soil pH or the electrical conductivity of a saturated soil extract (ECe) is likely to be 'good', 'potentially limiting', or 'poor' for grain yield. Crops were also ranked according to their likely ability to yield well under saline, acidic, or sodic conditions. For all crops, the point at which grain yield was affected by soil constraints was variable and there was often only a small amount of published information available to help guide the identification of tolerance limits and rankings, particularly for sodicity. Many studies were also conducted under experimental conditions that differed from rainfed farming, which can affect the transferability of results. Confidence in the tolerance limits and rankings is thus only moderate and further work is required to confirm their applicability.
Clinical routine acquisition protocol for 3D relaxation‐compensated APT and rNOE CEST‐MRI of the human brain at 3T
Authors: Goerke Steffen , Breitling Johannes , Korzowski Andreas , Paech Daniel , Zaiss Moritz , Schlemmer Heinz‐Peter , Ladd Mark E. , Bachert Peter 
Published: February 2021

PurposeThe value of relaxation‐compensated amide proton transfer (APT) and relayed nuclear Overhauser effect (rNOE) chemical exchange saturation transfer (CEST)‐MRI has already been demonstrated in various neuro‐oncological clinical applications. Recently, we translated the approach from 7T to a clinically relevant magnetic field strength of 3T. However, the overall acquisition time was still too long for a broad application in the clinical setting. The aim of this study was to establish a shorter acquisition protocol whilst maintaining the contrast behavior and reproducibility.MethodsTen patients with glioblastoma were examined using the previous state‐of‐the‐art acquisition protocol at 3T. The acquired spectral data were retrospectively reduced to find the minimal amount of required information that allows obtaining the same contrast behavior. To further reduce the acquisition time, also the image readout was accelerated and the pre‐saturation parameters were further optimized.ResultsIn total, the overall acquisition time could be reduced from 19 min to under 7 min. One key finding was that, when evaluated by the relaxation‐compensated inverse metric, a contrast correction for B1‐field inhomogeneities at 3T can also be achieved reliably with CEST data at only one B1 value. In contrast, a 1‐point B1‐correction was not sufficient for the common linear difference evaluation. The reproducibility of the new clinical routine acquisition protocol was similar to the previous state‐of‐the‐art protocol with limits of agreement below 20%.ConclusionsThe substantial reduction in acquisition time by about 64% now allows the application of 3D relaxation‐compensated APT and rNOE CEST‐MRI for examinations of the human brain at 3T in clinical routine.
Health in the Inca heartland: A paleopathological analysis of burials from the Cuzco region of Peru
Authors: Andrushko Valerie A. 
Published: February 2021

AbstractWhile much is known about the rise and expansion of the Inca Empire (AD 1438–1532) throughout the Andean region of South America, the health effects of the empire in its capital region remain unclear. The present study addresses the Inca Empire's impact on health in the Cuzco region of Peru through an analysis of four conditions (dental enamel hypoplasias, cribra orbitalia, porotic hyperostosis and periosteal lesions) in 929 pre‐Inca and Inca burials. The study results show little change in health from the Late Intermediate Period (AD 1000–1438) to the Inca Imperial Period (AD 1438–1532). When the location of the Inca burial sites was analysed, individuals from sites closest to the centre of the empire's capital showed lower frequencies in pathological conditions compared with individuals from sites in the countryside. These results suggest that individuals centred in the Inca imperial sphere benefited from their position and experienced better health. A similar finding was also seen with the previous Wari occupation of Cuzco in the Middle Horizon (AD 600–1000), as burials within the Wari imperial sphere exhibited fewer non‐specific stress indicators than those outside of it. Overall, the frequencies of pathological conditions in the Cuzco region, which ranged from 4.6% for porotic hyperostosis to 18.8% for periosteal lesions, were lower than frequencies from many coastal Peruvian sites. These differences may relate to a diverse diet provided by the Cuzco region ecosystem, as well as the absence of ecological challenges that affected coastal populations.
Life and death of four individuals in the destruction of the Late Bronze Age city of Azekah, Israel
Authors: Berendt Karl , Garvie‐Lok Sandra , Mayne Correia Pamela , Lipschits Oded , Gadot Yuval 
Published: February 2021

AbstractIn this article, we discuss the skeletal remains of four individuals discovered trapped below destruction debris of Building T2/627 at the site of Tel Azekah, Israel, dating to the late 12th Century BCE. Osteological analysis shows that these individuals suffered from anemia and other systemic illness during their lives. Patterns of musculoskeletal stress markers show that they were likely highly active; in the context of artifacts recovered from the building, we suggest that specific activities included grinding grain and carrying heavy objects. Heat damage to the remains shows that the bodies were extensively burned. The archaeological and osteological evidence suggest that a high temperature fire fueled by flammable goods stored in the building caused the building to collapse on top of these individuals, preserving their burnt remains in situ. Together, these lines of evidence enhance our understanding of these individuals' ways of life and manners of death against the backdrop of the “crisis years” of the Late Bronze Age Collapse during the end of the 2nd Millennium BCE.
Four Cycles of Etoposide plus Cisplatin for Patients with Good-Risk Advanced Germ Cell Tumors
Authors: Funt Samuel A. , McHugh Deaglan J. , Tsai Stephanie , Knezevic Andrea , O'Donnell Devon , Patil Sujata , Silber Deborah , Bromberg Maria , Carousso Maryann , Reuter Victor E. , Carver Brett S. , Sheinfeld Joel , Motzer Robert J. , Bajorin Dean F. , Bosl George J. , Feldman Darren R. 
Published: February 2021

AbstractBackgroundThe National Comprehensive Cancer Network recommends either three cycles of bleomycin, etoposide, and cisplatin or four cycles of etoposide and cisplatin (EPx4) as initial chemotherapy for the treatment of good-risk germ cell tumors (GCTs). To assess the response, toxicity, and survival outcomes of EPx4, we analyzed our experience.Material and MethodsResponse and survival outcomes, selected toxicities, and adherence to chemotherapy dose and schedule were assessed in patients with good-risk GCT who received EPx4 at Memorial Sloan Kettering Cancer Center between 1982 and 2016. The results were compared with our past results and published data.ResultsBetween 1982 and 2016, 944 patients with GCT were treated with EPx4, 289 who were previously reported plus 655 treated between January 2000 and August 2016. A favorable response was achieved in 928 of 944 patients (98.3%). Five-year progression-free, disease-specific, and overall survival rates were 93.9%, 98.6%, and 97.9%, respectively. Median follow-up was 7.3 years (range, 2.8 months to 35.5 years). Viable, nonteratomatous malignant GCT was present in 3.5% of 432 postchemotherapy retroperitoneal lymph node dissection specimens from patients with nonseminomatous GCT. Febrile neutropenia and thromboembolic events occurred in 16.0% and 8.9%, respectively, with one treatment-related death. In the more recent 655-patient cohort, full-dose EPx4 was administered to 631 (96.3%), with deviations from planned treatment driven mainly by vascular (n = 13), hematologic (n = 11), renal (n = 7), or infectious (n = 5) events.ConclusionEPx4 is highly effective and well tolerated in patients with good-risk GCTs and remains a standard of care.Implications for PracticeFour cycles of etoposide and cisplatin (EPx4) is a standard-of-care regimen for all patients with good-risk germ cell tumors with a favorable response rate and disease-specific survival of 98%. Full-dose administration of etoposide and cisplatin and complete resection of residual disease lead to optimal outcomes. EPx4 should be the recommended regimen in active smokers, patients with reduced or borderline kidney function, and patients aged 50 years or older, which are patient groups at increased risk for bleomycin pulmonary toxicity. Because of a risk of acquired severe pulmonary illness, EPx4 may also be favored for patients who vape or use e-cigarettes and during ongoing transmission of severe acute respiratory syndrome coronavirus 2.
Reproductive health counseling and contraceptive use in adolescents with cystic fibrosis
Authors: Hernandez Angela M. , Burdick Bethany , Adeyemi‐Fowode Oluyemisi 
Published: February 2021

AbstractBackgroundCystic fibrosis (CF) is a progressive, genetic disease posing reproductive health concerns to affected women, such as high‐risk pregnancies and medication interactions leading to contraceptive failure. Reproductive health counseling in this population is of the utmost importance, but barriers to providing it include lack of time, knowledge, and provider discomfort. We sought to evaluate reproductive health counseling and contraceptive use in female adolescent CF patients.MethodsAn Institutional Review Board approved retrospective chart review was performed between March 2008 and March 2018. Females 10–21 years old with the diagnosis of CF were reviewed. Descriptive statistics were used.ResultsThirty‐three patients met inclusion criteria: 16 non‐sexually active and 17 sexually active. Thirteen patients were counseled about pregnancy risks. All sexually active patients used contraception, with the most common being condoms and combined oral contraceptive pills. Six pregnancies occurred, resulting in five live births and one termination.ConclusionsLess than half of patients were counseled about pregnancy and contraception, and most patients chose high failure methods. Female adolescents with CF should be routinely screened for sexual activity, offered long‐acting reversible contraception, and counseled on the effects of CF on pregnancy.
A multiple closed‐loops robotic calibration for accurate surgical puncture
Authors: Zheng Lingxiang , Zhang Zhesi , Wang Zhigang , Bao Kaiyang , Yang Lin , Yan Biao , Yan Zeping , Ye Weitao , Yang Rongqian 
Published: February 2021

AbstractBackgroundRobotic puncture system increasingly demands stringent standard in target location accuracy. The positional and orientational transformation relationships among all components of the system are supposed to be calibrated and identified preoperatively.AimsThe target location performance is directly determined by the calibration result. Therefore, a multiple closed‐loops calibration approach is proposed to achieve high‐level calibration accuracy in robotic puncture system.Materials & MethodsThis method takes as input the three‐dimensional position information of the retro‐reflective markers mounted on the surgical tool, which is detected by the optical tracking system in real time during robotic movement. There is less complicated mathematical derivation and calculation in the presented algorithm by applying the closed‐loop principle.ResultsExperimental results validate that it can achieve accurate robotic target location with less input data and computation‐cost, satisfying the clinical puncture requirements.DiscussionThe spatial calibration between robotic arm and optical tracking system efficiently realised by the presented approach present an alternative which can be safely applied to the robotic puncture system for accurate insertion.ConclusionOverall, a multiple closed‐loops calibration approach is proposed in this work, which may increase surgical efficiency.
Frameless stereotactic brain biopsy: A prospective study on robot‐assisted brain biopsies performed on 32 patients by using the RONNA G4 system
Authors: Dlaka Domagoj , Švaco Marko , Chudy Darko , Jerbić Bojan , Šekoranja Bojan , Šuligoj Filip , Vidaković Josip , Romić Dominik , Raguž Marina 
Published: February 2021

AbstractBackgroundWe present a novel robotic neuronavigation system (RONNA G4), used for precise preoperative planning and frameless neuronavigation, developed by a research group from the University of Zagreb and neurosurgeons from the University Hospital Dubrava, Zagreb, Croatia. The aim of study is to provide comprehensive error measurement analysis of the system used for the brain biopsy.MethodsFrameless stereotactic robot‐assisted biopsies were performed on 32 consecutive patients. Post‐operative CT and MRI scans were assessed to precisely measure and calculate target point error (TPE) and entry point error (EPE).ResultsThe application accuracy of the RONNA system for TPE was 1.95 ± 1.11 mm, while for EPE was 1.42 ± 0.74 mm. The total diagnostic yield was 96.87%. Linear regression showed statistical significance between the TPE and EPE, and the angle of the trajectory on the bone.ConclusionThe RONNA G4 robotic system is a precise and highly accurate autonomous neurosurgical assistant for performing frameless brain biopsies.
Dutch Brain Research Registry for study participant recruitment: Design and first results
Authors: Zwan Marissa D. , van der Flier Wiesje M. , Cleutjens Solange , Schouten Tamara C , Vermunt Lisa , Jutten Roos J. , van Maurik Ingrid S. , Sikkes Sietske A.M. , Flenniken Derek , Howell Taylor , Weiner Michael W. , Scheltens Philip , Prins Niels D. 
Published: February 2021

AbstractIntroductionThe Dutch Brain Research Registry aims to facilitate online recruitment of participants for brain disease studies.MethodsRegistrants were primarily recruited through an online social media campaign. The registration process included a short questionnaire, which was subsequently used in the prescreening process to match participants to studies.ResultsIn the first 18 months, 17,218 registrants signed up (58±11 years old, 78% female). Out of 34,696 study invitations that were sent, 36% were accepted by registrants, of which 50% to 84% were finally enrolled, resulting in 10,661 participants in 28 studies. Compared to non‐participants, study participants were more often older, male, more highly educated, retired or unemployed, non‐smoking, healthier, and more often had a family member with dementia.DiscussionThe Dutch Brain Research Registry facilitates effective matching of participants to brain disease studies. Participant factors related to study enrollment may reflect facilitators or barriers for participation, which is useful for improving recruitment strategies.
Incidence and Risk Factors for Long-Term Mesh Explantation Due to Infection in More than 100,000 Hernia Operation Patients
Authors: Ramos Radwan Dipp , O'Brien William J. , Gupta Kalpana , Itani Kamal M.F. 
Published: February 2021

BACKGROUND:
Infectious complications after hernia operation are potentially disastrous, often requiring long-term antibiotic administration, debridement, and mesh explantation. Our objective was to describe the long-term incidence and risk factors for synthetic mesh explantation due to infection after hernia operation in a large cohort.

STUDY DESIGN:
Retrospective database study using Veterans Affairs Surgical Quality Improvement Program and chart review of veterans undergoing abdominal or groin hernia repair with synthetic mesh implantation during 2008-2015. The main outcome was mesh explantation due to infection within 5 years.

RESULTS:
The study population consisted of 103,869 hernia operations, of which 74.3% were inguinal, 10.7% umbilical, and 15.0% ventral. Explantation incidence was highest among ventral (1.5%). Median explantation interval overall was 208 days. In multivariable logistic regression, all obesity levels from pre-obesity to obesity class III were associated with higher explantation risk. American Society of Anesthesiology physical status classification of 3 to 5 was associated with odds ratio (OR) of 1.7 (95% CI, 1.28 to 2.26), as was longer operative duration (OR 1.83; 95% CI, 1.51 to 2.21), and contaminated or dirty surgical wound classification (OR 2.27; 95% CI, 1.11 to 4.64). Umbilical repair (OR 6.11; 95% CI, 4.14 to 9.02) and ventral repair (OR 14.35; 95% CI, 10.39 to 19.82) were associated with higher risk compared with inguinal. Open repair was associated with a higher risk compared with laparoscopic (OR 3.57; 95% CI, 2.52 to 5.05). Deep incisional surgical site infection within 30 days of operation was more likely to result in long-term mesh explantation (29.2%) than either superficial (6.4%) or organ space infection (22.4%).

CONCLUSIONS:
Mesh explantation for infection is most common after ventral hernia repair. Risk factor optimization is crucial to minimize such an end point.
Infectious Complication in Relation to the Prophylactic Mesh Position: The PRIMA Trial Revisited
Authors: Van den Dop Matthijs L. , Sneiders Dimitri , Kleinrensink Gert-Jan , Jeekel Hans J. , Lange Johan F. , Timmermans Lucas 
Published: February 2021

BACKGROUND:
Prophylactic mesh reinforcement has proven to reduce the incidence of incisional hernia (IH). Fear of infectious complications may withhold the widespread implementation of prophylactic mesh reinforcement, particularly in the onlay position.

STUDY DESIGN:
Patients scheduled for elective midline surgery were randomly assigned to a suture closure group, onlay mesh group, or sublay mesh group. The incidence, treatment, and outcomes of patients with infectious complications were assessed through examining the adverse event forms. Data were collected prospectively for 2 years after the index procedure.

RESULTS:
Overall, infectious complications occurred in 14/107 (13.3%) patients in the suture group and in 52/373 (13.9%) patients with prophylactic mesh reinforcement (p = 0.821). Infectious complications occurred in 17.6% of the onlay group and 10.3% of the sublay group (p = 0.042). Excluding anastomotic leakage as a cause, these incidences were 16% (onlay) and 9.7% (sublay), p = 0.073. The mesh could remain in-situ in 40/52 (77%) patients with an infectious complication. The 2-year IH incidence after onlay mesh reinforcement was 10 in 33 (30.3%) with infectious complications and 15 in 140 (9.7%) without infectious complications (p = 0.003). This difference was not statistically significant for the sublay group.

CONCLUSIONS:
Prophylactic mesh placement was not associated with increased incidence, severity, or need for invasive treatment of infectious complications compared with suture closure. Patients with onlay mesh reinforcement and an infectious complication had a significantly higher risk of developing an incisional hernia, compared with those in the sublay group.