bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protection of elephants and sustainable use of ivory in Thailand
Authors: Chaitae Apinya , Gordon Iain J. , Addison Jane , Marsh Helene 
Published: September 2021

AbstractThe Asian elephantElephas maximusis of cultural significance for the Thai people. The development of legal protection for elephants in Thailand dates back to the 17th century, reflecting concerns about both human livelihoods and elephant conservation. The legal status of privately owned, captive elephants differs from that of wild individuals, with consequences for the lawful use of ivory from captive animals. Prior to 2015, the lack of comprehensive measures to control the Thai ivory market enabled the laundering of illegally sourced ivory in the country. The Thai government introduced legal reforms in 2015, imposing strict controls over the possession and domestic trade of ivory from captive Asian elephants, and aligning the protection of African elephants and their ivory with CITES regulations. Nonetheless, the sustainable use of Thai ivory remains disputed, and international pressure to close the commercial trade in domestic ivory persists. Here we review this complex situation, aiming to inform future reforms. Consolidation of laws related to elephants and ivory would facilitate law enforcement and compliance. Use of an electronic database would improve the monitoring of ivory movements and aid the implementation and enforcement of laws.
Γameσσetai/γe Maσσetai: HomerIliad9.394 and the Constitutive Role of Irregularity
Authors: Ward Matthew 
Published: September 2021

AbstractThis paper uses a textual decision atIliad9.394 to argue for irregularity as a functional and meaningful principle in the constitution of the Homeric text. In contrast to almost all recent major editions, I argue that the ‘irregular’ MSS γαμέσσεται should be preferred to the Aristarchaean conjecture γε μάσσεται. Aristarchus’ widely adopted emendation, I suggest, is the product of a drive towards standardization that is still operative in Homeric text-critical practice. This paper opposes that standardization with the evidence of ancient, perhaps pre-Alexandrian, responses toIliad9.394, in which the ‘irregularity’ of γαμέσσεται is embraced as an interpretive opportunity. The formal disruptions of γαμέσσεται, I propose, can be understood by locating them both within the immediate context ofIliad9 and within the wider thematics of irregularity that mark the character of Achilles. This paper thus attempts to reframe our approach to the role of irregularity in theIliadas an integral feature of meaning rather than grounds for suspecting the integrity of the text.
Predictors of reading comprehension in deaf and hearing bilinguals
Authors: Cates Deborah M. , Traxler Matthew J. , Corina David P. 
Published: September 2021

AbstractThis study investigates reading comprehension in adult deaf and hearing readers. Using correlational analysis and stepwise regression, we assess the contribution of English language variables (e.g., vocabulary comprehension, reading volume, and phonological awareness), cognitive variables (e.g., working memory (WM), nonverbal intelligence, and executive function), and language experience (e.g., language acquisition and orthographic experience) in predicting reading comprehension in deaf and hearing adult bilinguals (native American Sign Language (ASL) signers, non-native ASL signers, and Chinese–English bilinguals (CEB)), and monolingual (ML) controls. For all four groups, vocabulary knowledge was a strong contributor to reading comprehension. Monolingual English speakers and non-native deaf signers also showed contributions from WM and spoken language phonological awareness. In contrast, CEB showed contributions of lexical strategies in English reading comprehension. These cross-group comparisons demonstrate how the inclusion of multiple participant groups helps us to further refine our understanding of how language and sensory experiences influence reading comprehension.
Regulating sense and space in late Renaissance Florence
Authors: Rombough Julia 
Published: September 2021

AbstractThis article examines the sounds and smells of late Renaissance Florence by analysing stone inscriptions posted in public streets and squares by the city's policing officials, the Otto di Guardia, during the Medici grand ducal period (1569–1737). The plaques contain sensory regulations prohibiting sounds, smells and sights considered socially and environmentally polluting. Unpublished archival records, printed materials and material artifacts reveal how sensory legislation developed as an increasingly public element of late Renaissance Florentine governance, while at the same time revealing how Florentines often resisted or ignored sensory regulation. Digitally mapping the sensory legislation plaques visualizes the intersections of sense, space and social history in new ways.
Art therapy and self-image: A 5-year follow-up art therapy RCT study of women diagnosed with breast cancer
Authors: Thyme Karin Egberg , Tavelin Björn , Öster Inger , Lindh Jack , Wiberg Britt 
Published: September 2021

AbstractObjectiveThis follow-up study on perceived self-image and psychophysical distress/psychic symptoms was based on a ranomized contolled study of art therapy on women with breast cancer.MethodThe aim was to examine the long-term effects of time-limited art therapy using the instruments of Structural Analysis of Social Behavior (SASB) and Symptom Check List-90 (SCL-90).ResultsThree attachment clusters of the SASB showed significant changes post therapy: Autonomous self (cluster 1), Accepting self (cluster 2), and Loving self (cluster 3). Clusters 2 and 3 continued to change in favor of the intervention group at the 5-year follow-up. There were no significant differences in the SCL-90 results between the intervention group and the control group in the follow-up study.Significance of resultsThe art therapy intervention was both therapeutic and psycho-educative. The conclusion of this study is that approaching emotions through time-limited art therapy seems to have a long-lasting effect on the attachment behavioral system shown in the SASB model post intervention, and this effect remained 5 years later.
Divine Visitation: The 1662 Prayer Book’s Theology of Sickness and Plague
Authors: Olver Matthew S. C. 
Published: September 2021

AbstractWhen it began to be clear that COVID-19 was a global phenomenon, clerics were scrambling for liturgical ways to address the crisis. But it turned out that most twentieth-century Anglican Prayers Books have few, if any, prayers for times of plague or great sickness. This was not always the case. In light of the current pandemic and the pastoral challenges it has introduced, this article explores the theology of sickness and plague in the Church of England’s 1662 Book of Common Prayer in light of the devastating history of plagues and sicknesses in England, both before and after the sixteenth-century reformations. This exploration makes use of the lens of ‘divine visitation’ as an ordering principle, one of the distinctive phrases that the Prayer Book uses repeatedly to speak of bodily illness.
Electron Density Reconstruction by Ionospheric Tomography From the Combination of GNSS and Upcoming LEO Constellations
Authors: Ren Xiaodong , Mei Dengkui , Zhang Xiaohong , Freeshah Mohamed , Xiong Si 
Published: September 2021

AbstractComputerized ionospheric tomography (CIT) based on Global Navigation Satellite System (GNSS) data is a worthwhile project. However, predominant issues like unevenly distributed stations, lack of data, and high‐elevation GNSS signals could affect the precise information about the ionosphere. To address this problem, many previous studies were mainly improving tomographic algorithms, rather than incorporating multisource data such as data from rapidly developed upcoming Low‐Earth‐Orbit (LEO) satellites. In this paper, the potential improvements of GNSS‐based ionospheric tomography at a global scale by combining the upcoming LEO constellations is investigated. On this basis, some numerical experiments were conducted to evaluate the performances of LEO‐augmented GNSS ionospheric tomography. Specifically, the slant total electron contents (STEC) required for ionospheric tomography from ground receivers to GNSS (including GPS, GLONASS, BDS, and Galileo) and LEO satellites are simulated by the international reference ionosphere (IRI‐2016) model during low and high solar activity in 2018 and 2014, respectively. The simulated STEC values from single‐, double‐ and quad systems of GNSS constellations were first used for ionospheric tomography. Afterward, the GNSS‐based STEC values were combined with the LEO‐based simulated STEC values. The STEC values directly derived from the IRI‐2016 model that have not been used in ionospheric tomography were used as independent references. The results showed that the GNSS + LEO solutions outperform the GNSS‐only solutions overall, the STEC values obtained by GNSS + LEO solutions are more consistent with the STEC references during both high and low years of solar activity. In comparison with the STEC references, the RMS values of the CIT‐derived STEC for GNSS‐only solutions can be decreased by 15% and 20.3% at most during low and high years of solar activity, respectively.
Significant Emissions From Forest Drainage Ditches—An Unaccounted Term in Anthropogenic Greenhouse Gas Inventories?
Authors: Peacock Mike , Granath Gustaf , Wallin Marcus B. , Högbom Lars , Futter Martyn N. 
Published: September 2021

AbstractForestry is a natural climate solution for removing atmospheric carbon dioxide (CO2) and reaching net zero emissions. Managed boreal forests typically have extensive drainage ditch networks, and these can be hotspots of anthropogenic greenhouse gas (GHG) emissions, potentially offsetting the terrestrial carbon gain. However, there is a lack of data detailing GHG emissions from ditches on mineral soils, where most boreal forestry occurs. Here, we address this knowledge gap using two approaches. First, we conducted a synoptic campaign to measure summer GHG fluxes from 109 boreal forest ditches draining mineral soils within one local region. We found a clear control of ditch water level on methane (CH4), with zero emissions from dry ditches and variable, but often high, emissions from water‐filled ditches. Almost all ditches acted as sources of CO2, regardless of water status. Second, we reanalyzed a published data set of boreal forest ditches and streams across three regions where GHG concentrations had been repeatedly measured and detailed catchment information was available. Within this data set we categorized 76 ditches into mineral and peatland catchments and detected no difference in mean CH4 and CO2 concentrations between the two soil types. GHG emissions from ditches draining mineral forest soils can be as large as those from peatland forest ditches. Using literature values for forest GHG uptake we demonstrate that ditch CH4 emissions are particularly important and can offset the terrestrial CH4 uptake. Ignoring ditch emissions, which are anthropogenic in origin, will lead to incorrect estimates of the landscape‐scale forest GHG budget.
Production and persistence of specific antibodies in COVID-19 patients with hematologic malignancies: role of rituximab
Authors: Cattaneo C. , Cancelli V. , Imberti L. , Dobbs K. , Sottini A. , Pagani C. , Belotti A. , Re A. , Anastasia A. , Quaresima V. , Tucci A. , Chiorini J. A. , Su H. C. , Cohen J. I. , Burbelo P. D. , Rossi G. , Notarangelo L. D. 
Published: September 2021

AbstractThe ability of patients with hematologic malignancies (HM) to develop an effective humoral immune response after COVID-19 is unknown. A prospective study was performed to monitor the immune response to SARS-CoV-2 of patients with follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), chronic lymphoproliferative disorders (CLD), multiple myeloma (MM), or myelodysplastic/myeloproliferative syndromes (MDS/MPN). Antibody (Ab) levels to the SARS-CoV-2 nucleocapsid (N) and spike (S) protein were measured at +1, +3, +6 months after nasal swabs became PCR-negative. Forty-five patients (9 FL, 8 DLBCL, 8 CLD, 10 MM, 10 MDS/MPS) and 18 controls were studied. Mean anti-N and anti-S-Ab levels were similar between HM patients and controls, and shared the same behavior, with anti-N Ab levels declining at +6 months and anti-S-Ab remaining stable. Seroconversion rates were lower in HM patients than in controls. In lymphoma patients mean Ab levels and seroconversion rates were lower than in other HM patients, primarily because all nine patients who had received rituximab within 6 months before COVID-19 failed to produce anti-N and anti-S-Ab. Only one patient requiring hematological treatment after COVID-19 lost seropositivity after 6 months. No reinfections were observed. These results may inform vaccination policies and clinical management of HM patients.
The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme
Authors: Urban-Wójciuk Zuzanna , Graham Amy , Barker Karen , Kwok Colin , Sbirkov Yordan , Howell Louise , Campbell James , Woster Patrick M. , Poon Evon , Petrie Kevin , Chesler Louis 
Published: September 2021

AbstractDeregulated polyamine biosynthesis is emerging as a common feature of neuroblastoma and drugs targeting this metabolic pathway such as DFMO are in clinical and preclinical development. The polyamine analog verlindamycin inhibits the polyamine biosynthesis pathway enzymes SMOX and PAOX, as well as the histone demethylase LSD1. Based on our previous research in acute myeloid leukemia (AML), we reasoned verlindamycin may also unblock neuroblastoma differentiation when combined with all-trans-retinoic acid (ATRA). Indeed, co-treatment with verlindamycin and ATRA strongly induced differentiation regardless of MYCN status, but in MYCN-expressing cells, protein levels were strongly diminished. This process was not transcriptionally regulated but was due to increased degradation of MYCN protein, at least in part via ubiquitin-independent, proteasome-dependent destruction. Here we report that verlindamycin effectively induces the expression of functional tumor suppressor—antizyme via ribosomal frameshifting. Consistent with previous results describing the function of antizyme, we found that verlindamycin treatment led to the selective targeting of ornithine decarboxylase (the rate-limiting enzyme for polyamine biosynthesis) as well as key oncoproteins, such as cyclin D and Aurora A kinase. Retinoid-based multimodal differentiation therapy is one of the few interventions that extends relapse-free survival in MYCN-associated high-risk neuroblastoma and these results point toward the potential use of verlindamycin in this regimen.
Local auxin biosynthesis acts downstream of brassinosteroids to trigger root foraging for nitrogen
Authors: Jia Zhongtao , Giehl Ricardo F. H. , von Wirén Nicolaus 
Published: September 2021

AbstractLateral roots (LRs) dominate the overall root surface of adult plants and are crucial for soil exploration and nutrient acquisition. When grown under mild nitrogen (N) deficiency, flowering plants develop longer LRs to enhance nutrient acquisition. This response is partly mediated by brassinosteroids (BR) and yet unknown mechanisms. Here, we show that local auxin biosynthesis modulates LR elongation while allelic coding variants of YUCCA8 determine the extent of elongation under N deficiency. By up-regulating the expression ofYUCCA8/3/5/7and ofTryptophan Aminotransferase of Arabidopsis 1(TAA1) under mild N deficiency auxin accumulation increases in LR tips. We further demonstrate that N-dependent auxin biosynthesis in LRs acts epistatic to and downstream of a canonical BR signaling cascade. The uncovered BR-auxin hormonal module and its allelic variants emphasize the importance of fine-tuning hormonal crosstalk to boost adaptive root responses to N availability and offer a path to improve soil exploration by expanded root systems in plants.
Parental relatedness through time revealed by runs of homozygosity in ancient DNA
Authors: Ringbauer Harald , Novembre John , Steinrücken Matthias 
Published: September 2021

AbstractParental relatedness of present-day humans varies substantially across the globe, but little is known about the past. Here we analyze ancient DNA, leveraging that parental relatedness leaves genomic traces in the form of runs of homozygosity. We present an approach to identify such runs in low-coverage ancient DNA data aided by haplotype information from a modern phased reference panel. Simulation and experiments show that this method robustly detects runs of homozygosity longer than 4 centimorgan for ancient individuals with at least 0.3 × coverage. Analyzing genomic data from 1,785 ancient humans who lived in the last 45,000 years, we detect low rates of first cousin or closer unions across most ancient populations. Moreover, we find a marked decay in background parental relatedness co-occurring with or shortly after the advent of sedentary agriculture. We observe this signal, likely linked to increasing local population sizes, across several geographic transects worldwide.
An active tethering mechanism controls the fate of vesicles
Authors: An Seong J. , Rivera-Molina Felix , Anneken Alexander , Xi Zhiqun , McNellis Brian , Polejaev Vladimir I. , Toomre Derek 
Published: September 2021

AbstractVesicle tethers are thought to underpin the efficiency of intracellular fusion by bridging vesicles to their target membranes. However, the interplay between tethering and fusion has remained enigmatic. Here, through optogenetic control of either a natural tether—the exocyst complex—or an artificial tether, we report that tethering regulates the mode of fusion. We find that vesicles mainly undergo kiss-and-run instead of full fusion in the absence of functional exocyst. Full fusion is rescued by optogenetically restoring exocyst function, in a manner likely dependent on the stoichiometry of tether engagement with the plasma membrane. In contrast, a passive artificial tether produces mostly kissing events, suggesting that kiss-and-run is the default mode of vesicle fusion. Optogenetic control of tethering further shows that fusion mode has physiological relevance since only full fusion could trigger lamellipodial expansion. These findings demonstrate that active coupling between tethering and fusion is critical for robust membrane merger.
Grain-growth mediated hydrogen sorption kinetics and compensation effect in single Pd nanoparticles
Authors: Alekseeva Svetlana , Strach Michal , Nilsson Sara , Fritzsche Joachim , Zhdanov Vladimir P. , Langhammer Christoph 
Published: September 2021

AbstractGrains constitute the building blocks of polycrystalline materials and their boundaries determine bulk physical properties like electrical conductivity, diffusivity and ductility. However, the structure and evolution of grains in nanostructured materials and the role of grain boundaries in reaction or phase transformation kinetics are poorly understood, despite likely importance in catalysis, batteries and hydrogen energy technology applications. Here we report an investigation of the kinetics of (de)hydriding phase transformations in individual Pd nanoparticles. We find dramatic evolution of single particle grain morphology upon cyclic exposure to hydrogen, which we identify as the reason for the observed rapidly slowing sorption kinetics, and as the origin of the observed kinetic compensation effect. These results shed light on the impact of grain growth on kinetic processes occurring inside nanoparticles, and provide mechanistic insight in the observed kinetic compensation effect.
Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma
Authors: Alvarez-Benayas Jaime , Trasanidis Nikolaos , Katsarou Alexia , Ponnusamy Kanagaraju , Chaidos Aristeidis , May Philippa C. , Xiao Xiaolin , Bua Marco , Atta Maria , Roberts Irene A. G. , Auner Holger W. , Hatjiharissi Evdoxia , Papaioannou Maria , Caputo Valentina S. , Sudbery Ian M. , Karadimitris Anastasios 
Published: September 2021

AbstractMultiple myeloma is a genetically heterogeneous cancer of the bone marrow plasma cells (PC). Distinct myeloma transcriptome profiles are primarily driven by myeloma initiating events (MIE) and converge into a mutually exclusive overexpression of the CCND1 and CCND2 oncogenes. Here, with reference to their normal counterparts, we find that myeloma PC enhanced chromatin accessibility combined with paired transcriptome profiling can classify MIE-defined genetic subgroups. Across and within different MM genetic subgroups, we ascribe regulation of genes and pathways critical for myeloma biology to unique or shared, developmentally activated or de novo formed candidate enhancers. Such enhancers co-opt recruitment of existing transcription factors, which although not transcriptionally deregulated per se, organise aberrant gene regulatory networks that help identify myeloma cell dependencies with prognostic impact. Finally, we identify and validate the critical super-enhancer that regulates ectopic expression of CCND2 in a subset of patients with MM and in chronic lymphocytic leukemia.
Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
Authors: Warrington Nicole M. , Hwang Liang-Dar , Nivard Michel G. , Evans David M. 
Published: September 2021

AbstractEstimation of direct and indirect (i.e. parental and/or sibling) genetic effects on phenotypes is becoming increasingly important. We compare several multivariate methods that utilize summary results statistics from genome-wide association studies to determine how well they estimate direct and indirect genetic effects. Using data from the UK Biobank, we contrast point estimates and standard errors at individual loci compared to those obtained using individual level data. We show that Genomic structural equation modelling (SEM) outperforms the other methods in accurately estimating conditional genetic effects and their standard errors. We apply Genomic SEM to fertility data in the UK Biobank and partition the genetic effect into female and male fertility and a sibling specific effect. We identify a novel locus for fertility and genetic correlations between fertility and educational attainment, risk taking behaviour, autism and subjective well-being. We recommend Genomic SEM be used to partition genetic effects into direct and indirect components when using summary results from genome-wide association studies.
Adjacent single-atom irons boosting molecular oxygen activation on MnO2
Authors: Gu Huayu , Liu Xiao , Liu Xiufan , Ling Cancan , Wei Kai , Zhan Guangming , Guo Yanbing , Zhang Lizhi 
Published: September 2021

AbstractEfficient molecular oxygen activation is crucial for catalytic oxidation reaction, but highly depends on the construction of active sites. In this study, we demonstrate that dual adjacent Fe atoms anchored on MnO2 can assemble into a diatomic site, also called as MnO2-hosted Fe dimer, which activates molecular oxygen to form an active intermediate species Fe(O = O)Fe for highly efficient CO oxidation. These adjacent single-atom Fe sites exhibit a stronger O2 activation performance than the conventional surface oxygen vacancy activation sites. This work sheds light on molecular oxygen activation mechanisms of transition metal oxides and provides an efficient pathway to activate molecular oxygen by constructing new active sites through single atom technology.