bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Corporate Dimension of the Cold War in Hungary: ITT and the Vogeler/Sanders Case Reconsidered
Authors: Manchester Margaret Murányi 
Published: June 2021

Abstract
In 1949, two executives at the Hungarian subsidiary of the U.S. conglomerate International Telephone & Telegraph (ITT), Robert Vogeler of the United States and Edgar Sanders of Great Britain, along with five Hungarian nationals, were arrested, tortured, given peremptory trials, and imprisoned for espionage and economic sabotage. This article reexamines the case in light of the diplomatic efforts to secure their release. The case needs to be understood in the context of U.S. intelligence agencies’ policies during the early Cold War. Numerous organizations that were not necessarily well coordinated embarked on intelligence-gathering and a variety of covert operations, some of which were undertaken with the cooperation of multinational corporations such as ITT. Vogeler and Sanders were indeed guilty of many of the charges leveled against them, and their ordeal was significant because it revealed the ineffectiveness of Cold War policies to influence behavior behind the Iron Curtain during the Stalin era.
U.S.-Soviet Handshakes in Space and the Cold War Imaginary
Authors: Jenks Andrew 
Published: June 2021

Abstract
This article examines the Apollo-Soyuz Test Project in 1975 as an instrument of diplomacy and as a catalyst for East-West détente. The topic has received little attention in either the general literature on the Cold War—which has only recently begun to address the political significance of science and technology more generally—or in the literature on space history, which has focused mostly on the earlier race to land on the moon and has devoted little attention to the collaboration in space that has dominated crewed space missions from the 1970s, leading up to the International Space Station. The article connects two previously separate spheres of study—space history and diplomatic history—to shed light on the importance of space exploration in the bigger story of Cold War diplomacy.
Stratospheric vacillations in a minimal contour dynamics model
Authors: Hitchcock Peter 
Published: June 2021

AbstractA low-dimensional dynamical system that describes dynamical variability of the stratospheric polar vortex is presented. The derivation is based on a linearized, contour-dynamics representation of quasigeostrophic shallow water flow on a polar f-plane. The model consists of a single linear wave mode propagating on a near-circular patch of constant potential vorticity (PV). The PV jump at the vortex edge serves as an additional degree of freedom. The wave is forced by surface topography, and interacts with the vortex through a simplified parameterization of diabatic wave/mean flow interaction. The approach can be generalized to other geometries.The resulting three-component system depends on four non-dimensional parameters, and the structure of the steady state solutions can be determined analytically in some detail. Despite its extreme simplification, the model exhibits variability that is closely analogous to the Holton-Mass model, a well-known and more complex dynamical model of stratospheric variability. The present model exhibits two stable steady solutions, one consisting of a strong vortex with a small amplitude wave and the second consisting of a weak vortex with a large amplitude wave. Periodic and aperiodic limit cycles are also identified, analogous to similar solutions in the Holton-Mass model. Model trajectories also exhibit a number of behaviors that have been identified in observations. A key insight is that the time-mean state of the vortex is predominantly controlled by the properties of the linear mode, while the strength of the topographic forcing plays a far weaker role away from bifurcations.
Using the CDC Worksite Health ScoreCard to Promote Organizational Change
Authors: Safeer Richard Scott , Lucik Meg Mia , Christel Katherine Claire 
Published: June 2021

Purpose: To measure the impact of tying adoption of evidence-based worksite health promotion (WHP) interventions to annual organizational strategic objectives, as measured by the Centers for Disease Control and Prevention (CDC) Worksite Health ScoreCard (ScoreCard). Design: A prospective cohort study following Johns Hopkins Medicine (JHM) affiliates against industry-specific and large employer benchmarks from 2016-2020. Settings: JHM, the largest private employer in Maryland with facilities in Florida and the District of Columbia. Subjects: Twelve JHM affiliates representing over 40,000 employees. Intervention: A strategic objective was established annually based on the ScoreCard and organizational priorities. Measures: JHM affiliates measured their WHP efforts annually using the ScoreCard. CDC industry-specific and large employer benchmarks were collected for comparison. Analysis: ScoreCard data was assessed annually to measure deviations from CDC benchmarks, determine whether strategic objectives were met, and inform additional annual objectives. Results: JHM demonstrated improvement from 8.9 percentage points above industry-specific and 3.4 percentage points below large employer benchmarks in 2016, to 26.4 percentage points above industry-specific and 21.8 percentage points above large employer benchmarks in 2020. Conclusion: Large employers face unique challenges in implementing WHP programs. Our study suggests embedding health promotion in annual strategic objectives may alleviate these challenges by prioritizing the goal and ensuring adequate resources to be successful. There are however, some limitations on using benchmarking data for comparison.
Circ_0000615 promotes high glucose-induced human retinal pigment epithelium cell apoptosis, inflammation and oxidative stress via miR-646/YAP1 axis in diabetic retinopathy
Authors: Zeng Qiang , Luo YiTing , Fang Junxu , Xu Shuang , Hu Yuan-Hua , Yin Ming 
Published: June 2021

Background: Diabetic retinopathy (DR), a common complication of diabetes mellitus, is the major cause of visual impairment and blindness. Circ_0000615 was found to be elevated in retina samples of diabetic patients. Hence, the detailed effects and molecular mechanisms of circ_0000615 in DN progression were explored. Methods: The levels of circ_0000615, microRNA (miR)-646 and YAP1 (yes-associated protein 1) were detected using quantitative real-time polymerase chain reaction and Western blot assays. Cell viability, apoptosis, inflammation and reactive oxygen species (ROS) generation were determined using cell counting kit-8 assay, flow cytometry, caspase3 activity analysis, Western blot, enzyme-linked immunosorbent assay (ELISA) and Dichlorofluorescein diacetate (DCFH-DA) assay, respectively. The binding interaction between miR-646 and circ_0000615 or YAP1 was determined using dual-luciferase reporter, RNA immunoprecipitation (RIP), and RNA pull-down assays. Results: Circ_0000615 was elevated in high glucose (HG)-induced human retinal pigment epithelium (HRPE) cells. Knockdown of circ_0000615 attenuated HG-triggered HRPE cell apoptosis, inflammation, and ROS generation. Mechanistically, miR-646 was confirmed to be a target of circ_0000615, inhibition of miR-646 reversed the protective effects of circ_0000615 knockdown on HG-evoked HRPE cell dysfunction. MiR-646 was verified to target YAP1, overexpression of YAP1 abolished the impairment induced by miR-646 on HG-induced HRPE cell damage. Besides that, we confirmed that circ_0000615 could regulate YAP1 expression via miR-646. Conclusion: Circ_0000615 contributed to HG-induced HRPE cell dysfunction via miR-646/YAP1 axis, suggesting a novel insight into the pathogenesis of DR and a potential candidate for DR treatment.
Role of awareness on cervical cancer screening uptake among HIV positive women in Addis Ababa, Ethiopia: A cross-sectional study
Authors: Emru Kassahun , Abebaw Tsega-Ab , Abera Admas 
Published: June 2021

Background: Cervical cancer is the second commonest cancer among women living in less developed countries. Although cervical cancer screening for HIV-infected women has been started in different centers in Addis Ababa, there is a paucity of data on the uptake of this service, particularly among HIV-infected women. Objective: This study is aimed to assess the level and determinants of cervical cancer screening uptake among HIV-positive reproductive-age women in Addis Ababa, Ethiopia. Methods: A cross-sectional study was conducted using a structured questionnaire on 411 HIV-infected women aged 15–49 years in St. Paul’s and Zewditu Hospitals. Data were collected using a pre-tested structured questionnaire on randomly selected study participants’ proportional allocation in the two hospitals. Logistic regression analyses were used to assess predictors of cervical cancer screening uptake. Results: Only 25.5% of HIV-positive reproductive-age women have been screened for cervical cancer. Respondents who have not heard about cervical cancer and the screening were 75% and 78% less likely to be screened compared to their counterparts, respectively. Conclusion: The uptake of cervical cancer screening was low in the study area. Awareness about cervical cancer screening was positively associated with cervical cancer screening uptake. Specific awareness programs focusing HIV positive women need to be implemented.
Bronchial brushing Xpert improves the diagnostic efficiency of sputum Xpert in patients with pulmonary tuberculosis
Authors: He Yu , Wu Yan-Hua , Han Chao , Gong Huai-Zheng , Wang Mao-Shui 
Published: June 2021

Background: The role of bronchial brushing Xpert MTB/RIF (hereafter referred to as Xpert) in patients with pulmonary tuberculosis (PTB) remains unclear. Therefore, a retrospective study was conducted aiming to evaluate the diagnostic efficiency of bronchial brushing Xpert in patients with PTB. Methods: Between July 2018 and August 2019, suspected PTB patients who were admitted to our hospital and had bronchial brushing and matched sputum collection for acid-fast bacilli (AFB) smear, mycobacterial culture, and Xpert were included for further analysis. Subsequently, PTB was defined based on mycobacterial culture, and if an alternative diagnosis was established, ‘non-tuberculosis (TB)’ was considered. Comparison of bronchial brushing and matched sputum examination was performed between groups. Then, the differences in the sensitivities between bronchial brushing and sputum Xpert were examined using the chi-square test. Results: A total of 111 patients were included and divided into TB and non-TB groups (52 versus 59 patients). The sensitivities of Xpert against culture were calculated as follows: sputum, 44.2% (23/52); bronchial brushing, 59.6% (31/52); sputum and bronchial brushing, 69.2% (36/52). The specificities of all Xpert assays were the same (100.0%, 59/59). A significant difference was found in the comparison of the sensitivities of Xpert using sputum, bronchial brushing and both, and the sensitivity of Xpert on both sputum and bronchial brushing was higher than that on sputum alone ( p < 0.05). Moreover, it appears that bronchial brushing Xpert was more sensitive than sputum Xpert in the detection of PTB. Conclusion: Bronchial brushing Xpert improves the diagnostic efficiency of sputum Xpert in the detection of PTB.
Patterns of Technology Use Among Patients With Head and Neck Cancer and Implications for Telehealth
Authors: Warinner Chloe B. , Hayirli Tuna C. , Bergmark Regan W. , Sethi Rosh , Rettig Eleni M. 
Published: June 2021

ObjectiveTo describe baseline technology use within the head and neck cancer (HNC) population prior to the COVID‐19 pandemic.Study DesignCross‐sectional analysis of National Health Interview Survey (NHIS) data.SettingThe NHIS is a survey of population health administered in person annually to a nationally representative sample of noninstitutionalized US residents via a complex clustered sampling design.MethodsData regarding technology use, cancer history, and demographics were extracted from the NHIS. The study population comprised individuals who completed the NHIS Sample Adult survey from 2012 to 2018 and self‐reported a cancer diagnosis. Poisson regression was used to evaluate associations between demographics and general or health‐related technology use and prevalence ratios reported.ResultsPatients with HNC were less likely to use general technology (computers, internet, or email) when compared with other patients with cancer (60% vs 73%, P <. 001), although this difference was not statistically significant after controlling for sociodemographic factors. Among patients with HNC, older age, lower education, and lower income were negatively associated with general technology use (adjusted prevalence ratio [aPR], 0.71 [95% CI, 0.59‐0.87] for age 65‐79 years vs <50 years; aPR, 0.66 [95% CI, 0.51‐0.85] for high school vs master; aPR, 0.66 [95% CI, 0.48‐0.91] for income 100%‐200% vs >400% federal poverty level). Older age and lower education were negatively associated with health‐related technology use (aPR, 0.46 [95% CI, 0.32‐0.67] for age 65‐79 years vs <50 years; aPR, 0.47 [95% CI, 0.30‐0.74] for high school vs master).ConclusionSocioeconomic disparities exist in technology use rates among patients with HNC. Access to technology may pose a barrier to telehealth visits for many patients with HNC due to the unique socioeconomic demographics of this patient population.
Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2/Keap1/xCT signaling
Authors: Fu Dazhi , Wang Chunxiao , Yu Lei , Yu Rui 
Published: June 2021

Abstract
Background
Currently, resistance against cisplatin (DDP) is a frequent problem for the success of advanced gastric carcinoma (GC) chemotherapy. Here, we sought to investigate the function of activating transcription factor 3 (ATF3) n GC chemoresistance.

Methods
Expression of ATF3 was determined in GC cell lines (MNK45, SGC7901, and BGC823) and cisplatin (DDP)-resistant cells (SGC7901/DDP and BGC823/DDP). Biological informatics was performed to analyze ATF3 expression and prognosis in GC patients. Cisplatin resistance was evaluated. Ferroptosis was detected after ATF3 transfection of cells. The underlying molecular mechanism was also investigated.

Results
Transcripts of ATF3 were decreased in GC cells and GC tissues. Kaplan–Meier plotter analysis revealed that ATF3 expression was positively related to the overall survival of GC patients. In particular, lower levels of ATF3 were observed in cisplatin-resistant SGC7901/DDP and BGC823/DDP relative to their parental cells. Notably, ATF3 elevation sensitized cisplatin-resistant cells to cisplatin. Mechanically, compared with parental cells, SGC7901/DDP and BGC823/DDP cells exhibited lower ferroptosis evident by lower ROS, MDA and lipid peroxidation and higher intracellular GSH levels. However, ATF3 elevated ferroptosis in SGC7901/DDP and BGC823/DDP cells. Intriguingly, ATF3 overexpression together with ferroptosis activator erastin or RSL3 treatment further enhanced ferroptosis and cisplatin resistance; however, the ferroptosis suppressor liproxstatin-1 reversed the function of ATF3 in ferroptosis and cisplatin resistance. Additionally, cisplatin-resistant cells exhibited stronger activation of Nrf2/Keap1/xCT signaling relative to parental cells, which was restrained by ATF3 up-regulation. Importantly, restoring Nrf2 signaling overturned ATF3-mediated ferroptosis and cisplatin resistance.

Conclusion
ATF3 may sensitize GC cells to cisplatin by induction of ferroptosis via blocking Nrf2/Keap1/xCT signaling, supporting a promising therapeutic approach for overcoming chemoresistance in GC.
Review of Recent Progress on Vertical GaN-Based PN Diodes
Authors: Pu Taofei , Younis Usman , Chiu Hsien-Chin , Xu Ke , Kuo Hao-Chung , Liu Xinke 
Published: June 2021

AbstractAs a representative wide bandgap semiconductor material, gallium nitride (GaN) has attracted increasing attention because of its superior material properties (e.g., high electron mobility, high electron saturation velocity, and critical electric field). Vertical GaN devices have been investigated, are regarded as one of the most promising candidates for power electronics application, and are characterized by the capacity for high voltage, high current, and high breakdown voltage. Among those devices, vertical GaN-based PN junction diode (PND) has been considerably investigated and shows great performance progress on the basis of high epitaxy quality and device structure design. However, its device epitaxy quality requires further improvement. In terms of device electric performance, the electrical field crowding effect at the device edge is an urgent issue, which results in premature breakdown and limits the releasing superiorities of the GaN material, but is currently alleviated by edge termination. This review emphasizes the advances in material epitaxial growth and edge terminal techniques, followed by the exploration of the current GaN developments and potential advantages over silicon carbon (SiC) for materials and devices, the differences between GaN Schottky barrier diodes (SBDs) and PNDs as regards mechanisms and features, and the advantages of vertical devices over their lateral counterparts. Then, the review provides an outlook and reveals the design trend of vertical GaN PND utilized for a power system, including with an inchoate vertical GaN PND.
Challenging diagnosis of leprosy in a psychotic homeless patient with atypical clinical manifestations: an interesting case report
Authors: Gunawan Hendra , Johan Reyshiani , Achdiat Pati Aji , Suwarsa Oki 
Published: June 2021

Abstract
Background
A decision to diagnose certain skin diseases in patient undergoing psychotic break is challenging; this includes establishing the diagnosis of leprosy. Diagnosis of leprosy is established if there is at least one of the three cardinal signs of leprosy. Histopathological examination is not a gold standard, but remains useful in atypical or clinically suspicious cases.

Case presentation
We report for the first time, an interesting case of leprosy with atypical clinical manifestations in a psychotic homeless male with unknown history of present illness. Upon examination, hypopigmented macules, hyperpigmented macules, and plaques were observed, with unclear sensation impairment. Peripheral nerve thickening and acid-fast bacilli from slit-skin smear were not found. Histopathological examination from hypopigmented macule on the upper right limb showed no granulomatous reaction and other histopathological features of leprosy. Although the condition did not fulfill the cardinal signs of leprosy, we found lagophthalmos, claw hands, pseudomutilation of fingers and toes. Therefore, the diagnosis of suspected leprosy was established. The patient was hospitalized and attempts to administer oral rifampicin and clofazimine were made. Several days after treatment, annular erythematous macules appeared on the patient’s face, abdomen, and back. Histopathological examination results on sample taken from erythematous macule and right sural nerve were consistent with the diagnosis of leprosy with reversal reaction.

Conclusion
In certain conditions, histopathological examination of the skin and nerves are a highly rewarding test in establishing a diagnosis of leprosy.
Assessment of breast arteries and lymph nodes by 3D MR angiography enhancement imaging: feasibility and pilot clinical results
Authors: Liu Yang , Hou Jiaxin , Zhu Zhijun , Liu Bingguang , Cao Manrui , Qin Wenjian 
Published: June 2021

Abstract
Background
Conventional dynamic contrast enhanced (DCE) magnetic resonance (MR) hardly achieves a good imaging performance of arteries and lymph nodes in the breast area. Therefore, a new imaging method is needed for the assessment of breast arteries and lymph nodes.

Methods
We performed prospective research. The research included 52 patients aged from 25 to 64 between June 2019 and April 2020. The isotropic e-THRIVE sequence scanned in the coronal direction after DCE-THRIVE. Reconstructed images obtained by DCE-THRIVE and the coronal e-THRIVE were compared mainly in terms of the completeness of the lateral thoracic artery, thoracodorsal artery, and lymph nodes. We proposed a criterion for evaluating image quality. According to the criterion, images were assigned a score from 1 to 5 according to the grade from low to high. Two board-certified doctors evaluated images individually, and their average score was taken as the final result. The chi-square test was used to assess the difference.

Results
The coronal e-THRIVE score is 4.60, which is higher than the DCE-THRIVE score of 3.48, there are significant differences between the images obtained by two sequences (P = 1.2712e−8). According to the score of images, 44 patients (84.61%) had high-quality images on the bilateral breast. Only 3 patients’ (5.77%) images were not ideal on both sides. The improved method is effective for most patients to get better images.

Conclusions
The proposed coronal e-THRIVE scan can get higher quality reconstruction images than the conventional method to visualize the course of arteries and the distribution of lymph nodes in most patients, which will be helpful for the clinical follow-up treatment.
Interns’ perspectives on impacts of the COVID-19 pandemic on the medical school to residency transition
Authors: Winn Ariel S. , Weaver Matthew D. , O’Donnell Katherine A. , Sullivan Jason P. , Robbins Rebecca , Landrigan Christopher P. , Barger Laura K. 
Published: June 2021

Abstract
Background
The COVID-19 pandemic resulted in disruptions to medical school training and the transition to residency for new post-graduate year 1 resident-physicians (PGY1s). Therefore, the aim of this study was to understand the perspectives of United States PGY1s regarding the impact of the pandemic on these experiences. Our secondary aims were to understand how desire to practice medicine was impacted by the pandemic and whether PGY1s felt that they were able to meaningfully contribute to the COVID-19 response as students.

Method
We conducted a national, cross-sectional study of PGY1s who had recently graduated from medical school in 2020. A survey was distributed to PGY1s from across specialties, in programs distributed throughout the United States. It included questions about medical school training during the pandemic, impact on graduation timing and transition to internship, concerns about caring for patients with COVID-19, desire to practice medicine, and ability to meaningfully contribute to the pandemic. Findings are presented using descriptive statistics and univariate logistic regression models.

Results
1980 PGY1s consented to participate, 1463 completed the survey (74%), and 713 met criteria for this analysis. 77% of PGY1s reported that the pandemic adversely affected their connection with their medical school communities, and 58% reported that the pandemic impeded their preparation for intern year. 4% of PGY1s reported graduating medical school and practicing as an intern earlier than their expected graduation date. While the majority of PGY1s did not have a change in desire to practice medicine, PGY1s with concerns regarding personal health or medical conditions (OR 4.92 [95% CI 3.20–7.55] p < 0.0001), the health or medical conditions of others in the home (OR 4.41 [2.87–6.77], p < 0.0001]), and PGY1s with children (OR 2.37 [1.23–4.58], p < 0.0001) were more likely to report a decreased desire.

Conclusions
The COVID pandemic disrupted the social connectedness and educational experiences of a majority of PGY1 residents in a sample of trainees in United States training programs. Those with health concerns and children had particularly challenging experiences. As the current and subsequent classes of PGY1s affected by COVID-19 proceed in their training, ongoing attention should be focused on their training needs, competencies, and well-being.