bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex differences in acute cardiovascular care: a review and needs assessment
Authors: Vallabhajosyula Saraschandra , Verghese Dhiran , Desai Viral K , Sundaragiri Pranathi R , Miller Virginia M 
Published: March 2021

AbstractDespite significant progress in the care of patients suffering from cardiovascular disease, there remains a persistent sex disparity in the diagnosis, management, and outcomes of these patients. These sex disparities are seen across the spectrum of cardiovascular care, but, are especially pronounced in acute cardiovascular care. The spectrum of acute cardiovascular care encompasses critically ill or tenuous patients with cardiovascular conditions that require urgent or emergent decision-making and interventions. In this narrative review, the disparities in the clinical course, management, and outcomes of six commonly encountered acute cardiovascular conditions, some with a known sex-predilection will be discussed within the basis of underlying sex differences in physiology, anatomy, and pharmacology with the goal of identifying areas where improvement in clinical approaches are needed.
New biomarkers from multiomics approaches: improving risk prediction of atrial fibrillation
Authors: Kornej Jelena , Hanger Vanessa A , Trinquart Ludovic , Ko Darae , Preis Sarah R , Benjamin Emelia J , Lin Honghuang 
Published: March 2021

Abstract
Atrial fibrillation (AF) is a common cardiac arrhythmia leading to many adverse outcomes and increased mortality. Yet the molecular mechanisms underlying AF remain largely unknown. Recent advances in high-throughput technologies make large-scale molecular profiling possible. In the past decade, multiomics studies of AF have identified a number of potential biomarkers of AF. In this review, we focus on the studies of multiomics profiles with AF risk. We summarize recent advances in the discovery of novel biomarkers for AF through multiomics studies. We also discuss limitations and future directions in risk assessment and discovery of therapeutic targets for AF.
The RACE to the EAST. In pursuit of rhythm control therapy for atrial fibrillation—a dedication to Harry Crijns
Authors: Reissmann Bruno , Breithardt Günter , Camm A John , Van Gelder Isabelle C , Metzner Andreas , Kirchhof Paulus 
Published: March 2021

Abstract
The RACE trial was one of the first landmark trials to establish whether restoring and maintaining sinus rhythm could reduce morbidity and mortality in patients with atrial fibrillation (AF). Its neutral outcome shaped clinical decision-making for almost 20 years. However, there were two important treatment-related factors associated with mortality of rhythm control therapy at that time: One was safety of antiarrhythmic drug therapy, and the other one withdrawal of anticoagulation after restoration of sinus rhythm. Both concerns have been overcome, and, moreover, important knowledge considering the importance of time for the treatment of AF has been gained. These insights led to the concept of the EAST-AFNET 4 trial, and after more than two decades in the pursuit of ongoing therapeutic improvement, early rhythm control therapy has demonstrated to reduce a composite of cardiovascular death, stroke, and hospitalization for worsening of HF or acute coronary syndrome, by 21% (first primary outcome, absolute reduction 1.1 per 100 patient-years). For this entire period, Harry Crijns characterized the treatment of AF patients, and contributed decisively to realizing the benefit of rhythm control therapy. It is almost easier to list the clinical trials without Harry's involvement than to list those which he co-designed and led.
Non-human primate and human malaria: past, present and future
Authors: Antinori Spinello , Bonazzetti Cecilia , Giacomelli Andrea , Corbellino Mario , Galli Massimo , Parravicini Carlo , Ridolfo Anna Lisa 
Published: March 2021

Abstract

Background
Studies of the malaria parasites infecting various non-human primates (NHPs) have increased our understanding of the origin, biology and pathogenesis of human Plasmodium parasites.
This review considers the major discoveries concerning NHP malaria parasites, highlights their relationships with human malaria and considers the impact that this may have on attempts to eradicate the disease.

Results
The first description of NHP malaria parasites dates back to the early 20th century. Subsequently, experimental and fortuitous findings indicating that some NHP malaria parasites can be transmitted to humans have raised concerns about the possible impact of a zoonotic malaria reservoir on efforts to control human malaria.
Advances in molecular techniques over the last 15 years have contributed greatly to our knowledge of the existence and geographical distribution of numerous Plasmodium species infecting NHPs, and extended our understanding of their close phylogenetic relationships with human malaria parasites. The clinical application of such techniques has also made it possible to document ongoing spillovers of NHP malaria parasites (Plasmodium knowlesi, P. cynomolgi, P. simium, P. brasilianum) in humans living in or near the forests of Asia and South America, thus confirming that zoonotic malaria can undermine efforts to eradicate human malaria.

Conclusions
Increasing molecular research supports the prophetic intuition of the pioneers of modern malariology who saw zoonotic malaria as a potential obstacle to the full success of malaria eradication programmes. It is, therefore, important to continue surveillance and research based on one-health approaches in order to improve our understanding of the complex interactions between NHPs, mosquito vectors and humans during a period of ongoing changes in the climate and the use of land, monitor the evolution of zoonotic malaria, identify the populations most at risk and implement appropriate preventive strategies.
BAT99-9 – a WC4 Wolf−Rayet star with nitrogen emission: evidence for binary evolution?
Authors: Hillier D John , Aadland Erin , Massey Philip , Morrell Nidia 
Published: March 2021

ABSTRACT
An analysis of the Large Magellanic Cloud (LMC) WC4 star BAT99-9 (HD 32125, FD 4, Brey 7, WS 3) shows that the star still contains photospheric nitrogen. Three N emission features (N v λλ1238, 1242, N iv λ1719, and N iv λλ3479–3485) are unambiguously identified in the spectrum. cmfgen models of the star yield an N/C ratio of 0.004 ± 0.002 (by number) and a C/He ratio of $0.15_{-0.05}^{+0.10}$. Due to the similarity of BAT99-9 to other WC4 stars, and the good fit achieved by cmfgen to both the classic WC4 spectrum and the N lines, we argue that the N lines are intrinsic to BAT99-9. An examination of a limited set of rotating models for single-star evolution at LMC and Galactic metallicities shows that a model with a Galactic metallicity (z = 0.014) and a progenitor mass of around 50 M⊙ can have an N/C ratio similar to, or larger than, what we observe for a significant fraction of its lifetime. However, the LMC models (z = 0.006) are inconsistent with the observations. Both the single and binary BPASS models predict that many WC stars can have an N/C ratio similar to, or larger than, what we observe for a significant fraction of their lifetime. While the binary models cover a wider range of luminosities and provide a somewhat better match to BAT99-9, it is not currently possible to rule out BAT99-9 being formed through single-star evolution, given the uncertainties in mass-loss rates, and the treatment of convection and mixing processes.
A ring accelerator? Unusual jet dynamics in the IceCube candidate PKS 1502+106
Authors: Britzen S , Zajaček M , Popović L Č , Fendt C , Tramacere A , Pashchenko I N , Jaron F , Pánis R , Petrov L , Aller M F , Aller H D 
Published: March 2021

ABSTRACT
On 2019/07/30.86853 ut, IceCube detected a high-energy astrophysical neutrino candidate. The Flat Spectrum Radio Quasar PKS 1502+106 is located within the 50 per cent uncertainty region of the event. Our analysis of 15 GHz Very Long Baseline Array (VLBA) and astrometric 8 GHz VLBA data, in a time span prior and after the IceCube event, reveals evidence for a radio ring structure that develops with time. Several arc-structures evolve perpendicular to the jet ridge line. We find evidence for precession of a curved jet based on kinematic modelling and a periodicity analysis. An outflowing broad line region (BLR) based on the C iv line emission (Sloan Digital Sky Survey) is found. We attribute the atypical ring to an interaction of the precessing jet with the outflowing material. We discuss our findings in the context of a spine-sheath scenario where the ring reveals the sheath and its interaction with the surroundings (narrow line region, NLR, clouds). We find that the radio emission is correlated with the γ-ray emission, with radio lagging the γ-rays. Based on the γ-ray variability time-scale, we constrain the γ-ray emission zone to the BLR (30–200 rg) and within the jet launching region. We discuss that the outflowing BLR provides the external radiation field for γ-ray production via external Compton scattering. The neutrino is most likely produced by proton–proton interaction in the blazar zone (beyond the BLR), enabled by episodic encounters of the jet with dense clouds, i.e. some molecular cloud in the NLR.
Unveiling the distinct formation pathways of the inner and outer discs of the Milky Way with Bayesian Machine Learning
Authors: Ciucă Ioana , Kawata Daisuke , Miglio Andrea , Davies Guy R , Grand Robert J J 
Published: March 2021

ABSTRACT
We develop a Bayesian Machine Learning framework called BINGO (Bayesian INference for Galactic archaeOlogy) centred around a Bayesian neural network. After being trained on the Apache Point Observatory Galactic Evolution Experiment (APOGEE) and Kepler asteroseismic age data, BINGO is used to obtain precise relative stellar age estimates with uncertainties for the APOGEE stars. We carefully construct a training set to minimize bias and apply BINGO to a stellar population that is similar to our training set. We then select the 17 305 stars with ages from BINGO and reliable kinematic properties obtained from Gaia DR2. By combining the age and chemo-kinematical information, we dissect the Galactic disc stars into three components, namely the thick disc (old, high-[α/Fe], [α/Fe] ≳ 0.12), the thin disc (young, low-[α/Fe]), and the Bridge, which is a region between the thick and thin discs. Our results indicate that the thick disc formed at an early epoch only in the inner region, and the inner disc smoothly transforms to the thin disc. We found that the outer disc follows a different chemical evolution pathway from the inner disc. The outer metal-poor stars only start forming after the compact thick disc phase has completed and the star-forming gas disc extended outwardly with metal-poor gas accretion. We found that in the Bridge region the range of [Fe/H] becomes wider with decreasing age, which suggests that the Bridge region corresponds to the transition phase from the smaller chemically well-mixed thick to a larger thin disc with a metallicity gradient.
Time-scales to reach chemical equilibrium in ices at snowline distance around compact objects: the influence of accretion mass in the central object
Authors: Carvalho G A , Pilling S 
Published: March 2021

ABSTRACT
In this work, we analyse soft X-ray emission due to mass accretion on to compact stars and its effects on the time-scale to reach chemical equilibrium of eventual surrounding astrophysical ices exposed to that radiation. Reaction time-scales due to soft X-ray in water-rich and pure ices of methanol, acetone, acetonitrile, formic acid, and acetic acid were determined. For accretion rates in the range $\dot{m}=10^{-12}\!-\!10^{-8}\,{\rm M}_\odot$ yr−1 and distances in the range 1–3 LY from the central compact objects, the time-scales lie in the range 10–108 yr, with shorter time-scales corresponding to higher accretion rates. Obtained time-scales for ices at snow-line distances can be small when compared to the lifetime (or age) of the compact stars, showing that chemical equilibrium could have been achieved. Time-scales for ices to reach chemical equilibrium depend on X-ray flux and, hence, on accretion rate, which indicates that systems with low accretion rates may not have reached chemical equilibrium.
Peeling off foregrounds with the constrained moment ILC method to unveil primordial CMB B modes
Authors: Remazeilles Mathieu , Rotti Aditya , Chluba Jens 
Published: March 2021

ABSTRACT
Galactic foregrounds are the main obstacle to observations of the cosmic microwave background (CMB) B-mode polarization. In addition to obscuring the inflationary B-mode signal by several orders of magnitude, Galactic foregrounds have non-trivial spectral signatures that are partially unknown and distorted by averaging effects along the line of sight, within the pixel/beam window, and by various analysis choices (e.g. spherical harmonic transforms and filters). Statistical moment expansion methods provide a powerful tool for modelling the effective Galactic foreground emission resulting from these averaging effects in CMB observations, while blind component separation treatments can handle unknown foregrounds. In this work, we combine these two approaches to develop a new semiblind component separation method at the intersection of parametric and blind methods, called constrained moment ILC (cMILC). This method adds several constraints to the standard ILC method to deproject the main statistical moments of the Galactic foreground emission. Applications to maps are performed in needlet space and when compared to the NILC method, this helps in significantly reducing residual foreground contamination (bias, variance, and skewness) in the reconstructed CMB B-mode map, power spectrum, and tensor-to-scalar ratio. We consider sky simulations for experimental settings similar to those of LiteBIRD and PICO, illustrating which trade-offs between residual foreground biases and degradation of the constraint on r can be expected within the new cMILC framework. We also outline several directions that require more work in preparation for the coming analysis challenges.
What influences patients’ opinion of remission and low disease activity in psoriatic arthritis? Principal component analysis of an international study
Authors: Coates Laura C , Robinson Danielle E , Orbai Ana-Maria , Kiltz Uta , Leung Ying-Ying , Palominos Penelope , Cañete Juan D , Scrivo Rossana , Balanescu Andra , Dernis Emmanuelle , Meisalu Sandra , Ruyssen-Witrand Adeline , Eder Lihi , de Wit Maarten , Smolen Josef S , Lubrano Ennio , Gossec Laure 
Published: March 2021

AbstractObjectiveIn PsA, the treatment objective is remission or low disease activity (LDA), but patients’ perception of remission is poorly studied. This analysis aimed to identify factors associated with patient-defined remission.MethodsThis analysis uses ReFlaP data, an international PsA study, with remission defined as ‘At this time, is your psoriatic arthritis in remission, if this means: you feel your disease is as good as gone?’. Variables associated with, first, patient-defined remission and, second, LDA were identified using multivariable logistic regression and principal component analysis (PCA) to explore correlated variables.ResultsOf 424 patients (50.2% male, mean age 52 years) with established disease, 94 (22.2%) reported themselves as being in remission and 191 (45.0%) as LDA alone. In multivariable analysis pain, psoriasis, impact of disease, physician opinion of symptoms from joint damage and Groll comorbidity index were independent predictors of remission. For LDA, results were similar. Using PCA, variance explained was 74% by five components for men and 80% by six components for women. The key component from PCA for remission was, for both sex, disease impact (Psoriatic Arthritis Impact of Disease, pain and HAQ) explaining 22.2–27.5% of variance. Other factors included musculoskeletal disease activity, chronicity/joint damage, psoriasis, enthesitis and CRP. For LDA, similar factors were identified but the variance explained was lower (64–68%).ConclusionMany factors impact on patients’ opinion of remission, dominated by disease impact. Disease activity in multiple domains, chronicity/age, comorbidities and symptoms due to other conditions contribute to a robust model highlighting that patient-defined remission is multifaceted.Trials registrationClinicaltrials.gov, http://clinicaltrials.gov, NCT 03119805.
Trends in Medical School Application and Matriculation Rates Across the United States From 2001 to 2015: Implications for Health Disparities
Authors: Zhang Donglan , Li Gang , Mu Lan , Thapa Janani , Li Yan , Chen Zhuo , Shi Lu , Su Dejun , Son Heejung , Pagan Jose A. 
Published: March 2021

Purpose
Socioeconomic and geographic determinants of medical school application and matriculation may help explain the unequal distribution of physicians in the United States. This study describes trends in MD-granting medical school application and matriculation rates and explores the relationship between county median family income, proximity to a medical school, and medical school application and matriculation rates.

Method
Data were obtained from the Association of American Medical Colleges, including the age, gender, and Federal Information Processing Standards code for county of legal residence for each applicant and matriculant to U.S. MD-granting medical schools from 2001 through 2015. The application and matriculation rates in each county were calculated using the number of applicants and matriculants per 100,000 residents. Counties were classified into 4 groups according to the county median family income (high-income, middle-income, middle-low-income, low-income). The authors performed chi-square tests to assess trends across the study period and the association of county median family income with application and matriculation rates.

Results
There were 581,833 applicants and 262,730 (45.2%) matriculants to MD-granting medical schools between 2001 and 2015. The application rates per 100,000 residents during 2001–2005, 2006–2010, and 2011–2015 were 57.2, 62.7, and 69.0, respectively, and the corresponding matriculation rates were 27.5, 28.1, and 29.8. The ratios of the application rate in high-income counties to that in low-income counties during the 3 time periods were 1.9, 2.4, and 2.8, respectively.

Conclusions
The application and matriculation rates to MD-granting medical schools increased steadily from 2001 to 2015. Yet, applicants and matriculants disproportionately came from high-income counties. The differences in the application and matriculation rates between low-income and high-income counties grew during this period. Exploring these differences can lead to better understanding of the factors that drive geographic differences in physician access and the associated health disparities across the United States.
Agreement between continuous noninvasive finger cuff-derived and invasive arterial blood pressure measurements: Effect of data sampling and data processing
Authors: Flick Moritz , Matin Mehr Jasmin , Briesenick Luisa , Hoppe Phillip , Kouz Karim , Vokuhl Christina , Flotzinger Doris , Lerche Katja , Saugel Bernd 
Published: March 2021

BACKGROUND
The effect of different methods for data sampling and data processing on the results of comparative statistical analyses in method comparison studies of continuous arterial blood pressure (AP) monitoring systems remains unknown.

OBJECTIVE
We sought to investigate the effect of different methods for data sampling and data processing on the results of statistical analyses in method comparison studies of continuous AP monitoring systems.

DESIGN
Prospective observational study.

SETTING
University Medical Center Hamburg-Eppendorf, Hamburg, Germany, from April to October 2019.

PATIENTS
49 patients scheduled for neurosurgery with AP measurement using a radial artery catheter.

MAIN OUTCOME MEASURES
We assessed the agreement between continuous noninvasive finger cuff-derived (CNAP Monitor 500; CNSystems Medizintechnik, Graz, Austria) and invasive AP measurements in a prospective method comparison study in patients having neurosurgery using all beat-to-beat AP measurements (Methodall), 10-s averages (Methodavg), one 30-min period of 10-s averages (Method30), Method30 with additional offset subtraction (Method30off), and 10 30-s periods without (Methodiso) or with (Methodiso-zero) application of the zero zone. The agreement was analysed using Bland-Altman and error grid analysis.

RESULTS
For mean AP, the mean of the differences (95% limits of agreement) was 9.0 (−12.9 to 30.9) mmHg for Methodall, 9.2 (−12.5 to 30.9) mmHg for Methodavg, 6.5 (−9.3 to 22.2) mmHg for Method30, 0.5 (−9.5 to 10.5) mmHg for Method30off, 4.9 (−6.0 to 15.7) mmHg for Methodiso, and 3.4 (−5.9 to 12.7) mmHg for Methodiso-zero. Similar trends were found for systolic and diastolic AP. Results of error grid analysis were also influenced by using different methods for data sampling and data processing.

CONCLUSION
Data sampling and data processing substantially impact the results of comparative statistics in method comparison studies of continuous AP monitoring systems. Depending on the method used for data sampling and data processing, the performance of an AP test method may be considered clinically acceptable or unacceptable.