bluuebunny/crossref_metadata_2025_split huggingface dataset:
MRI-Based Radiomics Nomogram for Selecting Ovarian Preservation Treatment in Patients With Early-Stage Endometrial Cancer
Authors: Yan Bi Cong , Ma Xiao Liang , Li Ying , Duan Shao Feng , Zhang Guo Fu , Qiang Jin Wei 
Published: September 2021

BackgroundOvarian preservation treatment (OPT) was recommended in young women with early-stage endometrial cancer [superficial myometrial invasion (MI) and grades (G) 1/2-endometrioid adenocarcinoma (EEC)]. A radiomics nomogram was developed to assist radiologists in assessing the depth of MI and in selecting eligible patients for OPT.MethodsFrom February 2014 to May 2021, 209 G 1/2-EEC patients younger than 45 years (mean 39 ± 4.3 years) were included. Of them, 104 retrospective patients were enrolled in the primary group, and 105 prospective patients were enrolled in the validation group. The radiomics features were extracted based on multi-parametric magnetic resonance imaging, and the least absolute shrinkage and selection operator algorithm was applied to reduce the dimensionality of the data and select the radiomics features that correlated with the depth of MI in G 1/2-EEC patients. A radiomics nomogram for evaluating the depth of MI was developed by combing the selected radiomics features with the cancer antigen 125 and tumor size. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic performance of the radiomics nomogram and of radiologists without and with the aid of the radiomics nomogram. The net reclassification index (NRI) and total integrated discrimination index (IDI) based on the total included patients to assess the clinical benefit of radiologists with the radiomics nomogram were calculated.ResultsIn the primary group, for evaluating the depth of MI, the AUCs were 0.96 for the radiomics nomogram; 0.80 and 0.86 for radiologists 1 and 2 without the aid of the nomogram, respectively; and 0.98 and 0.98 for radiologists 1 and 2 with the aid of the nomogram, respectively. In the validation group, the AUCs were 0.88 for the radiomics nomogram; 0.82 and 0.83 for radiologists 1 and 2 without the aid of the nomogram, respectively; and 0.94 and 0.94 for radiologists 1 and 2 with the aid of the nomogram, respectively. The yielded NRI and IDI values were 0.29 and 0.43 for radiologist 1 and 0.23 and 0.37 for radiologist 2, respectively.ConclusionsThe radiomics nomogram outperformed radiologists and could help radiologists in assessing the depth of MI and selecting eligible OPTs in G 1/2-EEC patients.
Cost-Effectiveness of Frontline Treatment for Advanced Renal Cell Carcinoma in the Era of Immunotherapies
Authors: Li SiNi , Li JianHe , Peng LiuBao , Li YaMin , Wan XiaoMin 
Published: September 2021

Background: Recent randomized controlled trials have demonstrated that immune checkpoint inhibitors (ICIs) improve patient outcomes, but whether these novel agents are cost-effective for untreated advanced renal cell carcinoma (aRCC) remains unclear.Materials and Methods: A microsimulation model was created to project the healthcare costs and outcomes of six strategies (lenvatinib-plus-pembrolizumab, nivolumab-plus-cabozantinib, nivolumab-plus-ipilimumab, pembrolizumab-plus-axitinib, avelumab-plus-axitinib, and sunitinib monotherapy) for patients with aRCC. Transition probability of patients was estimated from CLEAR, CheckMate 9ER, CheckMate 214, KEYNOTE-426, JAVELIN Renal 101, and other data sets by using parametric survival modeling. Lifetime direct medical costs, life years (LYs), quality-adjusted LYs (QALYs), and incremental cost-effectiveness ratios (ICERs) were estimated from a United States payer perspective. One-way and probabilistic sensitivity analyses were performed, along with multiple scenario analyses, to evaluate model uncertainty.Results: Of the six competing strategies, nivolumab-plus-cabozantinib yielded the most significant health outcomes, and the sunitinib strategy was the least expensive option. The cost-effective frontier consisted of the nivolumab-plus-cabozantinib, pembrolizumab-plus-axitinib, and sunitinib strategies, which displayed the ordered ICERs of $81282/QALY for pembrolizumab-plus-axitinib vs sunitinib and $453391/QALY for nivolumab-plus-cabozantinib vs pembrolizumab-plus-axitinib. The rest of the strategies, such as lenvatinib-plus-pembrolizumab, nivolumab-plus-ipilimumab, and avelumab-plus-axitinib, were dominated. The cost of sunitinib drove the model most influentially.Conclusions: For aRCC, the pembrolizumab-plus-axitinib strategy is likely to be the most cost-effective alternative at the willingness-to-pay threshold of $100,000.
The Impact of Social Support and Pregnancy on Subjective Well-Being: A Systematic Review
Authors: Battulga Buyantungalag , Benjamin Marc Reginald , Chen Hong , Bat-Enkh Enkhmandakh 
Published: September 2021

Background: Subjective well-being (SWB) has a protective role in mental health maintenance and is prone to change during short stressful moments, such as pregnancy. Longstanding research suggests that social support (SS) from the partner and family members of pregnant women directly or indirectly acts as a buffer against negative mental outcomes. For happier pregnancies, it is important to understand how SS and pregnancy affect the SWB.Objective: This review aims to examine the extended association of being pregnant and SS on the SWB of pregnant women.Methods: A systematic review was conducted in PubMed, ScienceDirect, and Google Scholar. Articles published in peer-reviewed journals were included regardless of the year and if they had assessed the impact of at least one SWB or SS outcome among healthy pregnant women. The tools of the National Heart, Lung, and Blood Institute were used for quality assessment.Results: Thirty-four studies that assessed the domains of SWB measurements, such as happiness, quality of life (QoL), life satisfaction, positive and negative effects, and well-being, were included and its association with either pregnancy or SS was summarized. Variable results, such as life satisfaction, happiness, and mental component of QoL, were found to be high during pregnancy, but positive emotion and physical components of QoL had decreased. Almost universally, SS during pregnancy was found to have a positive association with all measurements of SWB.Conclusion: This study had found that, despite some arising trends, pregnancy itself does not necessarily have similar impacts on SWB across healthy pregnant women. However, SS had a significant effect on SWB.
Generalized Anxiety Disorder, Depressive Symptoms, and Sleep Problem During COVID-19 Outbreak in Ethiopia Among Police Officers: A Cross-Sectional Survey
Authors: Tsehay Mekonnen , Necho Moges , Gelaye Habtam , Beyene Abeba , Birkie Mengesha 
Published: September 2021

Background: Coronavirus disease 2019 (COVID-19) is an outbreak that caused serious threats to people worldwide. Police officers are one of those frontline fighters during pandemic. Our study is the first to examine psychological health response among police officers in Ethiopia during the COVID-19 outbreak.Methods: A cross-sectional study design with a self-administered questionnaire was conducted among police officers from Dessie town from June 20 to July 10, 2020. A total of 385 questionnaires were completed correctly accounting for 91% of the total. The data were collected by using demographic information and psychological health assessment tools. The Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder 7-item scale (GAD-7), Insomnia Severity Index (ISI), and Brief Resilient Coping Scale questionnaire were used to assess depression, anxiety, sleep, and coping status of participants.Results: The rate of depression was found to be 28.9%. Of these, 19.7% had mild, 7.3% had moderate, 1.6 had moderate–severe, and 0.3% had severe depression symptoms. The rate of general anxiety symptoms was found to be 30.2%. Of these, 22.1% of the police officers had mild, 2.6% had moderate, and 5.5% had severe anxiety. Moreover, 13.8% of police officers had subthreshold insomnia and 2.1% had clinical (moderate–severe) insomnia. Participants who are men, married, highly resilient, and have high social support were associated with lower depression, anxiety, and insomnia scores than those of women, being single or widowed/divorced, low resilient coping score, and low social support, respectively.Conclusion: A psychological health problem was found to be higher among police officers in Dessie town. Younger age, sex, marital status, having chronic diseases, coping, and social support with depression, general anxiety, and insomnia were found to be significantly associated with psychological health problems. There is a need for mental health services, support, and care of police officers during the pandemic.
The Relationships Among Structural Social Support, Functional Social Support, and Loneliness in Older Adults: Analysis of Regional Differences Based on a Multigroup Structural Equation Model
Authors: Li Haifeng , Wang Cong 
Published: September 2021

Objective: This study investigated the relationship between structural social support and loneliness and explored whether functional social support had an intermediate role therein. It also employed a multigroup structural equation model to compare mediation models among older adults living in cities, towns, and rural areas.Methods: Using a self-made demographics questionnaire, the structural-functional social support scale, and the 3-item UCLA loneliness scale, this study collected information from 1,325 older adults identified via convenient sampling.Results: The results showed that as: (1) compared with older adults living in towns, older urban, and rural adults had higher structural social support and experienced less loneliness, while older adults’ functional social support showed no difference among the three regions (2) An analysis of the models of regional differences indicated that functional social support served as a full mediator in the relationship between structural social support and loneliness in urban older adults, and a partial mediator for older adults living in towns and rural areas.Conclusion: The relationship between structural social support and loneliness is mediated by functional social support, and this mediation model varies between older adults in cities and towns/rural areas. This study helps us understand possible mechanisms through which structural social support impacts loneliness. It suggests that nursing strategies for older adults should be adjusted according to the region and direct greater focus on the function (or quality) of the social support network and older adults living in towns.
Research Trends and Hotspots on Montessori Intervention in Patients With Dementia From 2000 to 2021: A Bibliometric Analysis
Authors: Zhou Ting , Qu Jiling , Sun Huiping , Xue Mengxin , Shen Yijing , Liu Yongbing 
Published: September 2021

Background: Patients with dementia experience a variety of neuropsychiatric symptoms and behavioral disturbances. The Montessori method is a type of non-pharmacological intervention to care for people with dementia. However, there are few bibliometric studies on the application of Montessori methods. We aimed to analyze the hotspots and trends of research on the application of Montessori methods to the care of dementia patients.Methods: Microsoft Office Excel, Co-Occurrence 9.9, and CiteSpace were used to analyze the articles on Montessori intervention in patients with dementia from 2000 to 2021 in China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, Web of Science core collection database, PubMed, and Scopus.Results: A total of 23 Chinese language publications and 113 English language publications were included. The number of English language publications was on the rise, while the number of Chinese language publications was low. There are many issuing institutions which published articles in this field, mostly concentrated in universities. English language publication sources were more than Chinese language publication sources. The hot research topic in Chinese language publications and English language publications was the care of agitated behavior of dementia patients based on the Montessori method. The psychological problems of dementia patients are likely to become a hot issue of concern for scholars in Chinese. There will be a lot of research focusing on dementia patients and their family caregivers in this field.Conclusion: The bibliometric and visualization analysis helps us understand the current research status and hotspots of Montessori intervention in dementia patients in Chinese language publications and English language publications.
Covid-19 Incidence and Mortality by Age Strata and Comorbidities in Mexico City: A Focus in the Pediatric Population
Authors: González-García Nadia , Castilla-Peón María F. , Solórzano Santos Fortino , Jiménez-Juárez Rodolfo Norberto , Martínez Bustamante Maria Elena , Minero Hibert Miguel Angel , Garduño-Espinosa Juan 
Published: September 2021

Background: SARS-COV2 appears less frequently and less severely in the pediatric population than in the older age groups. There is a need to precisely estimate the specific risks for each age group to design health and education policies suitable for each population.Objective: This study aimed to describe the risk of death in SARS-COV2 infected subjects by age group and according to the presence of comorbidities.Methods: We analyzed data of confirmed SARS-COV2 infection cases where symptoms began between February 22th, 2020, and April 18th, 2021, as published by the General Epidemiology Direction (DGE) of the Mexican Ministry of Health. We calculated COVID-19 incidence and mortality by age group using population data from the Statistics and Population National Institute (INEGI), and estimated the association between risk of death and the presence of comorbidities.Results: Mortality in SARS-COV2 infected people varied considerably, between 7 and 155 deaths per million per year in the under-20 age groups compared to 441 to 15,929 in the older age groups. Mortality in pediatric populations is strongly associated with comorbidities (OR: 4.6-47.9) compared to the milder association for older age groups (OR: 3.16–1.23).Conclusion: The risk of death from SARS-COV2 infection in children is low and is strongly associated with comorbidities.
PENGARUH SELF HELP GROUP UNTUK MENINGKATKAN KUALITAS HIDUP KELUARGA DALAM MERAWAT PASIEN SKIZOFRENIA
Authors: Yunita Rizka , Isnawati Iin Aini , Addiarto Widya 
Published: September 2021

Abstract: Schizophrenia is a mental disorder that requires treatment for a long time. This disease is easy to recur when the individual is under psychological pressure. This condition makes the family as the patient's closest party required to always accompany and assist him in carrying out activities. This situation makes the family feel that they are not free to work so that it makes them feel physically, psychologically and socially depressed as a result, the quality of family life decreases. The purpose of this study was to analyze Self Help Group (SHG) in improving the quality of family life caring for schizophrenia patients. This study used a quasy experimental design with a pre-post test with control group design. The study population was 40 respondents. The sampling technique used purposive sampling which a research sample of 36 respondents divided into 18 respondents in each control and treatment group. The results of this study showed that the average score of family quality of life in caring for schizophrenia patients in the control group before the health education intervention was 88.5 and after intervention was 92.78, while before the intervention in the treatment group was 87.28 and after it was 111.06. The result have significant ρ-value of 0,000 was also obtained, which means that there are differences in the quality of family life in caring for schizophrenic patients after being given intervention in the control and treatment groups. So it can be concluded that SHG is one of therapy applied as an intervention for families in order to improve their quality of life while caring for schizophrenia patients. Keywords: schizophrenia, family, quality of life, self-help group
THE EFFECT OF MATERNAL CARE (ACOUSTIC STIMULUS) ON EMBRYONIC DEVELOPMENT AND HATCHING MUSCLE OF BROILER CHICKENS.
Authors: M. Abdulateef S. 
Published: September 2021

This experiment was carried out at hatcheries and laboratories of Animal Production Department - College of Agricultural Sciences - University of Sulaymaniyah, by using 240 fertilized egg (Ross 308), distributed to four treatments,T1= first treatment control treatment without hearing any sound, T2= second treatment hearing the hen call , T3= treatment third hearing chicks hatched call and T4= treatment fourth hearing chick with hen call, each treatment divided to three replicates and each repeater 20 eggs, hearing the sound from the age of 5 days form incubation and until the day of hatching, the sound was given for a period of 15 minutes per hour in 24 hours, the results showing: significantly (P≤0.01) improvement in embryonic development traits for all experimental treatments in embryonic test second and third compared with the control treatment, significantly (P≤0.01) improvement in the quality specifications for the hatching muscle and histological test for all experimental treatments compared with control treatment.
EVALUATION OF ANTIOXIDANT FUNCTIONALITY OF FISH COLLAGEN ENZYMIC HYDROLYSATE
Authors: & Shakir Abbas 
Published: September 2021

This study aimed to investigate the anti- oxidative function of catfish collagen hydrolysate in beef minced meat samples through 10 days storage at 4 o C. Collagen hydrolysate were added to minced meat sample at two different concentrations (50 & 100 mg/100gm) . The experiment consist from control sample (C without additives) , BHT sample ( B with 200ppm butylated hydroxytoluene ) , collagenase hydrolysate samples C.C.H1, C.C.H2 (100&50 mg/100gm minced meat) respectively, and collagenase-trypsin hydrolysate samples C.H.T1 & C.H.T2 respectively (50,100mg/100gm minced meat). Peroxide values (PV), thiobarbutyric acid TBA, free fatty acid (FFA) , pH , total volatile nitrogen TVN values and total plate count assay at 0., 3, 7., 10 days were determined . PV of the BHT, C.C.H2 , C.H.T2, C.C.H1, C.H.T1 groups were significantly (p<0.05) lower than control during storage period .Meanwhile C.C.H2 and C.H.T2 groups gave the lowest TBA values through the storage period . There were no significant difference found between the C.C.H2 , C.H.T2 groups and BHT added group in all studied factors. In conclusion, the fish collagen enzymatic hydrolysates are a promising natural antioxidant and good alternative for synthetic antioxidant.
ISOLATION AND GENETIC DETECTION OF MORAXELLA BOVIS FROM BOVINE KERATOCONJUNCTIVITIS IN BASRAH CITY
Authors: & et al. Hadi 
Published: September 2021

This study was aimed to determine the most sensitive isolation procedures and evaluate the genetic diversity of Moraxella bovis because there are large number of pathogenic bacteria and several other infectious agents such as virus and Mycoplasma have been isolated from the eyes infected with infectious bovine keratoconjunctivitis (IBK). This study included examination of (40) eye swabs, from cows from different ages and regions in Basrah city showed clinical signs of an ocular infection. The isolated bacteria that obtained in pure cultures were non-motile, catalase and oxidase positive, and a clear zone of β-hemolytic colonies were produced on blood agar. According to the growth characteristics, morphology, staining and biochemical tests, the isolated bacteria were identified initially as Moraxella spp., the genetic diversity among Moraxella spp. was assessed by 16S rRNA and sequencing as M. bovis. The study has also indicated that the isolates of M. bovis were resistant to tetracycline, chloramphenicol and erythromycin, However, they were sensitive to penicillin and gentamicin and has an intermediate sensitivity to streptomycin. This study concluded that PCR techniques and sequencing were verified to be most accurate tools to indicate the genetic diversity between Moraxella spp. in bovine keratoconjunctivitis.
Honey and Children: The Effect of Honey from Apis cerana Bees on Children’ Nutritional Status in East Nusa Tenggara - Indonesia
Authors: Widowati Retno , Yasinta Marescoty Rosana  , Vivi Silawati  , Raushanfikri Albiruni 
Published: September 2021

This study aims to examine the effect of honey from Apis cerana bee colonies on nutritional status in children aged two to five years old in the working area of ​​Mok Community Health Center, Manggarai Regency, East Nusa Tenggara - Indonesia. The study was conducted in May - June 2018, with quasi-experiment design with pre and post test in one group. The sample in this study amounted to 35 children under five years old, with malnutritional status. Nutritional status is determined by the weight-for-age. The used honey was honey from the A. cerana bee colonies harvested in Manggarai Regency. Honey was consumed by children as much as 5 mL, twice a day, morning and evening, for 8 weeks. Nutritional status measurements were taken at 0 weeks, 4 weeks and 8 weeks before and after honey consumed regularly. Post-Hoc data analysis using the Wilcoxon Signed Rank Test. The results showed a significant increase in children's nutritional status at week 4 and week 8. The percentage of children with malnutritional status after being given honey A. cerana regularly for 4 weeks fell to 57% and good nutrition increased to 43%. Meanwhile, after 8 weeks of honey, the malnutritional status has decreased to 31%, and vice versa 69% of children have increased their nutritional status to good nutrition. The results of a comparative test of increasing nutritional status between 4 and 8 weeks showed that there was a significant difference between improving the nutritional status of children under five years old who consumed honey for 4 weeks and for 8 weeks. The research shows the length of time consumed A. cerana honey regularly in children aged two to five years old, will have a positive effect to the nutritional status from poor to good nutritional status.