bluuebunny/crossref_metadata_2025_split huggingface dataset:
РОЛЬ ДУХОВНО-МОРАЛЬНИХ ЦІННОСТЕЙ У ФОРМУВАННІ АКТИВНОЇ ГРОМАДЯНСЬКОЇ ПОЗИЦІЇ СТУДЕНТІВ
Authors: Задворняк Л. С. 
Published: February 2021

Залучення до професійно-особистісної культури студентів в освітньому процесі відбувається шляхом засвоєння ціннісних орієнтацій. Уявлення про цінності мають безпосереднє відношення до виховання, тому що змістом виховання є реалізація соціальних програм, що функціонують в системі цінностей. Духовно-моральні цінності – фактор, що визначає регуляцію поведінки особистості. Стаття присвячена вивченню механізмів формування ціннісних орієнтацій особистості. Розкрито сутнісно-змістовну основу громадянської позиції особистості, вказуючи на тісний зв'язок становлення громадянської позиції зі становленням духовно-моральних цінностей молодих людей. Визначено роль та значення духовних цінностей у формуванні громадянської позиції здобувачів вищої освіти. Обґрунтовано актуальну проблему розвитку духовно-моральних цінностей у громадянському вихованні молоді. Проаналізовано проблематику та показано необхідність прийняття корінних заходів щодо виправлення існуючого становища в сфері виховання та формування активної громадянської позиції студентів. Визначено духовно-моральні цінності особистості студента як важливий напрям вдосконалення психолого-педагогічного процесу професійного навчання, що створює умови для того, щоб кожен фахівець мав активну громадянську позицію, відданість обов'язку, сміливість, рішучість, відповідальність, порядність і чесність у відносинах між людьми, найвище розуміння соціальної значущості своєї діяльності в будь-яких ситуаціях.
MEMBANGUN DATABASE MENGGUNAKAN MICROSOFT ACCESS 2007
Authors: Anggraeni Dewi , Aswati Safrian , Maulina Azmi Sri Rezeki , Akmal Akmal , Dewi Muthia , Anwar Khairil 
Published: February 2021

Abstract: Community Service is done in the year 2017 period 2 at SMP Swasta Taman Siswa Kisaran, with the theme "Building Database Using Microsoft Access 2007". Given the very rapid technological developments, the knowledge of the database and how to build it is appropriate for teachers to know and able to make it, especially in SMP Swasta Taman Siswa Kisaran. This activity aims, in addition to the interest of lecturers with the affairs of Tri Dharma Perguruan Tinggi, but also equip teachers and students about the knowledge and techniques of building the database. Software used is Microsoft Access 2007. Benefits that can be taken after this activity is done, apart from the needs of lecturers to get functional positions, for teachers and students of course can build database related to their work, for example database for teacher data and student data in the school. This activity is only limited to the knowledge of the database and how / step / manufacturing techniques only. For the design of the application as a bridge of input, process, and output data, it is necessary to do further service in the future. Keywords : Database, Microsoft Access 2007, SMP Swasta Taman Siswa Abstrak: Pengabdian Kepada Masyarakat ini dilakukan di tahun 2017 periode ke 2 di SMP Swasta Taman Siswa Kisaran, dengan tema “Membangun Database Menggunakan Microsoft Access 2007”. Mengingat perkembangan teknologi begitu sangat cepat, maka pengetahuan tentang database dan bagaimana cara membangunnya sudah sewajarnya guru-guru mengetahuinya dan mampu membuatnya, khususnya di SMP Swasta Taman Siswa Kisaran. Kegiatan ini bertujuan, selain kepentingan dosen dengan urusan Tri Dharma Perguruan Tinggi, namun juga membekali guru-guru dan siswa tentang pengetahuan dan teknik membangun database. Software yang digunakan adalah Microsoft Access 2007. Manfaat yang dapat diambil setelah kegiatan ini dilakukan adalah, selain dari kebutuhan dosen untuk mendapat jabatan fungsional, untuk guru dan siswa tentunya dapat membangun database yang berhubungan dengan pekerjaan mereka, contohnya database untuk data guru dan data siswa di sekolah tersebut. Kegiatan ini hanya sebatas pengetahuan tentang database dan bagaimana cara/langkah/teknik pembuatannya saja. Untuk rancangan aplikasi sebagai jembatan input, proses, dan output data, maka perlu dilakukan pengabdian selanjutnya dikemudian hari. Kata kunci : Database, Microsoft Access 2007, SMP Swasta Taman Siswa
WORKSHOP MEMBANGUN SISTEM JARINGAN KOMPUTER BERBASIS PEER TO PEER DAN CLIENT SERVER DI SMK NEGERI 1 SETIA JANJI
Authors: Maha  Putra Guntur , Syafinur Afdhal , Yesputra Rolly 
Published: February 2021

Abstract: SMK Negeri 1 Setia Janji is a vocational high school that is engaged in technology that has three departments namely RPL (Software Engineering), TSM (Motorcycle Engineering) and TKR (Light Vehicle Engineering). Department of RPL is focused into mastery of programming, for example in making dynamic web application, but after finished making web application needed a computer network so that application can be run and can be arranged through computer network system either peer to peer or client server, it needs to be done collaboration between mastery in the field of programming with mastery in the field of computer network systems, especially based on peer to peer and client server. Keywords :Networking, peer to peer, client server Abstrak: SMK Negeri 1 Setia Janji adalah Sekolah Menengah Kejuruan yang bergerak di bidang teknologi yang memiliki tiga jurusan yaitu RPL (Rekayasa Perangkat Lunak), TSM (Teknik Sepeda Motor) dan TKR (Teknik Kendaraan Ringan). Jurusan RPL difokuskan ke dalam penguasaan pemrograman, misalnya dalam membuat aplikasi web dinamis, tetapi setelah selesai membuat aplikasi web tersebut maka diperlukan sarana jaringan komputer agar aplikasi tersebut dapat dijalankan dan dapat diatur melalui sistem jaringan komputer tersebut baik secara peer to peer maupun client server, oleh sebab itu perlu dilakukan kolaborasi antara penguasaan dibidang pemrograman dengan penguasaan di bidang sistem jaringan komputer khususnya berbasis peer to peer dan client server. Kata kunci : Jaringan, peer to peer, client server
KONFIGURASI DAN MANAJEMEN WINDOWS SERVER 2008 DI SMK NEGERI 1 SETIA JANJI
Authors: Maha Putra Guntur , Syafnur Afdhal , Yesputra Rolly 
Published: February 2021

Abstract : This community service activity is held in SMK Negeri 1 Setia Janji on the students of RPL (Software Engineering), amounting to 23 people. The purpose of the implementation of this activity is to provide training to participants about windows server 2008 management and implementation and configuration that has not been previously taught, so it is expected to improve the new skills for each participant. The method of implementing community service is done by providing training with the stages of the delivery of the material from the module and direct practice in the laboratory room. From the results of observations, interviews undertaken and the findings can be concluded that this community service activity provides a very large and targeted benefits, thereby providing additional insight and new knowledge in the field of information technology, especially windows server 2008 outside of learning that had been received by students in SMK Negeri 1 Setia Janji.Keywords: windows server 2008, configuration, managementAbstrak : Kegiatan pengabdian kepada masyarakat ini dilaksanakan di SMK Negeri 1 Setia Janji pada siswa-i jurusan RPL (Rekayasa Perangkat Lunak) yang berjumlah 23 orang. Tujuan dari pelaksanaan kegiatan ini adalah untuk memberikan pelatihan kepada peserta mengenai manajemen windows server 2008 beserta implementasi maupun konfigurasinya yang sebelumnya belum pernah diajarkan, sehingga diharapkan dapat meningkatkan keterampilan baru bagi diri masing-masing peserta. Metode pelaksanaan pengabdian kepada masyarakat dilakukan dengan cara memberikan pelatihan dengan tahapan penyampaian materi dari modul yang diberikan dan praktek langsung di ruang laboratorium. Dari hasil pengamatan, wawancara yang di lakukan serta temuan yang kami dapatkan dapat disimpulkan bahwa program pengabdian masyarakat ini memberikan manfaat yang sangat besar dan tepat sasaran, sehingga memberikan tambahan wawasan serta pengetahuan baru di bidang teknologi informasi, khususnya windows server 2008 di luar pembelajaran yang selama ini di terima oleh siswa-i di SMK Negeri 1 Setia Janji.Kata kunci : windows server 2008, konfigurasi, manajemen
Physicochemical and sensory analysis of salted cereals bars developed with vegetables rich in carotenoids
Authors: Costa Isabella Maciel , Silva Sabrina Sandy Vasconcelos da , Silva Amanda Nayara Abreu , Oliveira Franciele Marques de , Gonçalves Aline Cristina Arruda , Trombete Felipe Machado , Kobori Cintia Nanci 
Published: February 2021

Cereal bars are very appreciated by Brazilian consumers, especially because they are practical food with diverse flavors and compositions. They are easy to carry, do not need refrigeration, and can be a source of nutrients. However, salty cereal bars are not explored by food industries, and new formulations using healthier raw materials, such as rich in carotenoids vegetables, should be studied, especially concerning the acceptance of these new products by consumers. This study aimed to develop salted cereal bars with the addition of vegetables rich in carotenoids (dried tomato, dehydrated carrot and fresh kale). The physicochemical composition, texture analysis, and sensory acceptance were evaluated. Formulations with dried tomato and carrot were classified as a source of protein, while the cereal bars elaborated with kale can be classified as high protein content. The addition of cheese did not influence (p >0.05) the hardness parameter in texture analysis. Samples added of dried tomato showed the highest concentrations of total carotenoids. In the sensory analysis, the addition of the cheese layer only increased the color acceptance for the kale cereals bar (p<0.05). For the other sensory attributes, there was no significant difference (p> 0.05) between samples with or without cheese for the same flavor. The dried tomato and carrot cereal bars were the most accepted and did not differ statistically (p > 0.05) for all the attributes. Therefore, it was possible to develop salted cereal bars with the addition of vegetables rich in carotenoids and obtain good nutritional, physicochemical, and sensory characteristics.
Potential Target miR-455 Delaying Arterial Stenosis Progression Through PTEN
Authors: Lin Ruoran , Lv Junyuan , Wang Lei , Li Xuan , Zhang Jing , Sun Weifeng , Hu Xiaoyun , Xin Shijie 
Published: February 2021

Background: Vascular smooth muscle cells (VSMC) underwent phenotypic switching upon stimulation signals, and this is the prerequisite for their proliferation and migration. Previous work revealed that miR-455 may be involved in vascular stenosis. Thus, this study aimed to explore potential targets and mechanisms underlying the dynamics of miR-455 in vascular stenosis.Methods: miR-455 and PTEN expression levels were studied in normal and stenosis tissue, as well as in VSMC in proliferation model. Manipulating miR-455 expression levels was achieved by transfection of either miR-455 mimic or inhibitor, and its effect on cell proliferation was studied by CCK-8 assay. Its effect on gene expression was studied by RT-qPCR and western blot. The expression regulation mechanism was studied by luciferase reporter system. Finally, the effect of miR-455 on regulating vascular stenosis was studied using a rat balloon-injured carotid artery stenosis model.Results: High expression levels of miR-455 were detected in both stenosis arterial tissues and VSMC proliferation models. In contrast, the expression levels of PTEN were downregulated in these systems. miR-455 transfected VSMC showed higher levels of proliferation and decreased levels of PTEN. Potential binding sites between miR-455 and PTEN 3′UTR were predicted and confirmed. NF-kB p65 was found to bind directly on miR-455 promoter region and regulate its transcription. The progression of arterial stenosis could be delayed by introducing miR-455 antagomir.Conclusions: The p65/miR-455/PTEN signaling pathway plays a crucial role in regulating VSMC proliferation and vascular stenosis. This indicated that miR-455 is a novel target that would help improve treatment outcomes in patients suffering from vascular stenosis.
The Impact of Complex Volcanic Plumbing on the Nature of Seismicity in the Developing Magmatic Natron Rift, Tanzania
Authors: Reiss Miriam Christina , Muirhead James D. , Laizer Amani S. , Link Frederik , Kazimoto Emmanuel O. , Ebinger Cynthia J. , Rümpker Georg 
Published: February 2021

Constraining the architecture of complex 3D volcanic plumbing systems within active rifts, and their impact on rift processes, is critical for examining the interplay between faulting, magmatism and magmatic fluids in developing rift segments. The Natron basin of the East African Rift System provides an ideal location to study these processes, owing to its recent magmatic-tectonic activity and ongoing active carbonatite volcanism at Oldoinyo Lengai. Here, we report seismicity and fault plane solutions from a 10 month-long temporary seismic network spanning Oldoinyo Lengai, Naibor Soito volcanic field and Gelai volcano. We locate 6,827 earthquakes with ML−0.85 to 3.6, which are related to previous and ongoing magmatic and volcanic activity in the region, as well as regional tectonic extension. We observe seismicity down to ∼17 km depth north and south of Oldoinyo Lengai and shallow seismicity (3–10 km) beneath Gelai, including two swarms. The deepest seismicity (∼down to 20 km) occurs above a previously imaged magma body below Naibor Soito. These seismicity patterns reveal a detailed image of a complex volcanic plumbing system, supporting potential lateral and vertical connections between shallow- and deep-seated magmas, where fluid and melt transport to the surface is facilitated by intrusion of dikes and sills. Focal mechanisms vary spatially. T-axis trends reveal dominantly WNW-ESE extension near Gelai, while strike-slip mechanisms and a radial trend in P-axes are observed in the vicinity of Oldoinyo Lengai. These data support local variations in the state of stress, resulting from a combination of volcanic edifice loading and magma-driven stress changes imposed on a regional extensional stress field. Our results indicate that the southern Natron basin is a segmented rift system, in which fluids preferentially percolate vertically and laterally in a region where strain transfers from a border fault to a developing magmatic rift segment.
Sex-Specific Associations of MIR137 Polymorphisms With Schizophrenia in a Han Chinese Cohort
Authors: Yin Jingwen , Luo Xudong , Peng Qian , Xiong Susu , Lv Dong , Dai Zhun , Fu Jiawu , Wang Ying , Wei Yaxue , Liang Chunmei , Xu Xusan , Zhang Dandan , Wang Lulu , Zhu Dongjian , Wen Xia , Ye Xiaoqing , Lin Zhixiong , Lin Juda , Li You , Wang Jiafeng , Ma Guoda , Li Keshen , Wang Yajun 
Published: February 2021

Objective: To investigate the effects of microRNA-137 (MIR137) polymorphisms (rs1198588 and rs2660304) on the risk of schizophrenia in a Han Chinese population.Methods: Schizophrenia was diagnosed according to the DSM-5. Clinical symptoms and cognitive functions were assessed with the Positive and Negative Symptom Scale (PANSS) and Brief Assessment of Cognition in Schizophrenia (BACS), respectively. The polymorphisms were genotyped by improved multiplex ligation detection reaction (iMLDR) technology in 1,116 patients with schizophrenia and 1,039 healthy controls.Results: Significant associations were found between schizophrenia and MIR137 in the distributions of genotypes (p = 0.037 for rs1198588; p = 0.037 for rs2660304, FDR corrected) and alleles (p = 0.043 for rs1198588; p = 0.043 for rs2660304, FDR corrected) of two SNPs. When the population was stratified by sex, we found female-specific associations between MIR137 and schizophrenia in terms of genotype and allele distributions of rs1198588 (χ2 = 4.41, p = 0.036 and χ2 = 4.86, p = 0.029, respectively, FDR corrected) and rs2660304 (χ2 = 4.74, p=0.036 and χ2 = 4.80, p = 0.029, respectively, FDR corrected). Analysis of the MIR137 haplotype rs1198588-rs2660304 showed a significant association with schizophrenia in haplotype T-T [χ2 = 4.60, p = 0.032, OR = 1.32, 95% CI (1.02–1.70)]. Then, significant female-specific associations were found with the haplotypes T-T and G-A [χ2 = 4.92, p = 0.027, OR = 1.62, 95% CI (1.05–2.50); χ2 = 4.42, p = 0.035, OR = 0.62, 95% CI (0.39–0.97), respectively]. When the TT genotype of rs1198588 was compared to the GT+GG genotype, a clinical characteristics analysis also showed a female-specific association in category instances (t = 2.76, p = 0.042, FDR corrected).Conclusion: The polymorphisms within the MIR137 gene are associated with susceptibility to schizophrenia, and a female-specific association of MIR137 with schizophrenia was reported in a Han Chinese population.
The Role of Siglec-G on Immune Cells in Sepsis
Authors: Royster William , Wang Ping , Aziz Monowar 
Published: February 2021

Sepsis is a life-threatening clinical syndrome that results from an overwhelming immune response to infection. During sepsis, immune cells are activated by sensing pathogen-associated molecular patterns and damage-associated molecular patterns (DAMPs) through pattern recognizing receptors (PRRs). Regulation of the immune response is essential to preventing or managing sepsis. Sialic acid-binding immunoglobulin-type lectin-G (Siglec-G), a CD33 group of Siglec expressed in B-1a cells and other hematopoietic cells, plays an important immunoregulatory role. B-1a cells, a subtype of B lymphocytes, spontaneously produce natural IgM which confers protection against infection. B-1a cells also produce IL-10, GM-CSF, and IL-35 to control inflammation. Sialic acids are present on cell membranes, receptors, and glycoproteins. Siglec-G binds to the sialic acid residues on the B cell receptor (BCR) and controls BCR-mediated signal transduction, thereby maintaining homeostasis of Ca++ influx and NFATc1 expression. Siglec-G inhibits NF-κB activation in B-1a cells and regulates B-1a cell proliferation. In myeloid cells, Siglec-G inhibits DAMP-mediated inflammation by forming a ternary complex with DAMP and CD24. Thus, preserving Siglec-G’s function could be a novel therapeutic approach in sepsis. Here, we review the immunoregulatory functions of Siglec-G in B-1a cells and myeloid cells in sepsis. A clear understanding of Siglec-G is important to developing novel therapeutics in treating sepsis.
Ferromagnetism With High Curie Temperature of Cu Doped LiMgN New Dilute Magnetic Semiconductors
Authors: Deng Junquan , Yang Wuqing , Hu Aiyuan , Yu Peng , Cui Yuting , Ding Shoubing , Wu Zhimin 
Published: February 2021

New diluted magnetic semiconductors represented by Li(Zn,Mn)As with decoupled charge and spin doping have received much attention due to their potential applications for spintronics. However, their low Curie temperature seriously restricts the wide application of these spintronic devices. In this work, the electronic structures, ferromagnetic properties, formation energy, and Curie temperature of Cu doped LiMgN and the corresponding Li deficient system are calculated by using the first principles method based on density functional theory, combined with Heisenberg model in the Mean-Field Approximation. We find that the Cu doped systems have high temperature ferromagnetism, and the highest Curie temperature is up to 573K, much higher than the room temperature. Li(Mg0.875Cu0.125)N is a half metallic ferromagnet and its net magnetic moments are 2.0 μв. When Li is deficient, the half metallic ferromagnetism becomes stronger, the magnetic moments increase to 3.0 μв. The bonding and differential charge density indicate that the half metallic ferromagnetism can be mainly attributed to the strong hybridization between N 2p and doped Cu 3d orbitals. The results show that Cu doped LiMgN is a kind of ideal new dilute magnetic semiconductor that will benefit potential spintronics applications.
Effect of Spironolactone on COVID-19 in Patients With Underlying Liver Cirrhosis: A Nationwide Case-Control Study in South Korea
Authors: Jeon Dongsub , Son Minkook , Choi Jonggi 
Published: February 2021

Purpose: On the basis that spironolactone is involved in ACE2 expression and TMPRSS2 activity, previous studies have suggested that spironolactone may influence the infectivity of COVID-19. Research has suggested that cell entry of SARS-CoV-2, the virus that induces COVID-19, is associated with the ACE2 receptor and TMPRSS2. The purpose of this study was to investigate whether spironolactone has a protective effect against COVID-19 and the development of associated complications in patients with liver cirrhosis.Methods: We conducted a nationwide case-control study on liver cirrhosis patients with or without COVID-19 from the population-based data acquired from the National Health Insurance Systems of Republic of Korea. After 1:5 case-control matching, multivariable adjusted conditional logistic regression analysis was performed.Results: Among the patients with liver cirrhosis, the case group with COVID-19 was found to be significantly less exposed to spironolactone compared with the control group without COVID-19. The adjusted odds ratio (OR) and 95% confidence interval (CI) between the two groups was 0.20 (0.07–0.54). In addition, regardless of cumulative dose of spironolactone, exposure to spironolactone was associated with lower COVID-19 infection. In terms of the development of complications due to COVID-19, spironolactone did not show any significant association between the patients with and without complications (P = 0.43). The adjusted OR and 95% CI between the two groups was 1.714 (0.246–11.938).Conclusion: We conclude that spironolactone may reduce susceptibility to COVID-19 but does not affect the development of its associated complications; however, further studies are needed to confirm the exact association between spironolactone and COVID-19 infection.
BamA and BamD Are Essential for the Secretion of Trimeric Autotransporter Adhesins
Authors: Rooke Jessica L. , Icke Christopher , Wells Timothy J. , Rossiter Amanda E. , Browning Douglas F. , Morris Faye C. , Leo Jack C. , Schütz Monika S. , Autenrieth Ingo B. , Cunningham Adam F. , Linke Dirk , Henderson Ian R. 
Published: February 2021

The BAM complex in Escherichia coli is composed of five proteins, BamA-E. BamA and BamD are essential for cell viability and are required for the assembly of β-barrel outer membrane proteins. Consequently, BamA and BamD are indispensable for secretion via the classical autotransporter pathway (Type 5a secretion). In contrast, BamB, BamC, and BamE are not required for the biogenesis of classical autotransporters. Recently, we demonstrated that TamA, a homologue of BamA, and its partner protein TamB, were required for efficient secretion of proteins via the classical autotransporter pathway. The trimeric autotransporters are a subset of the Type 5-secreted proteins. Unlike the classical autotransporters, they are composed of three identical polypeptide chains which must be assembled together to allow secretion of their cognate passenger domains. In contrast to the classical autotransporters, the role of the Bam and Tam complex components in the biogenesis of the trimeric autotransporters has not been investigated fully. Here, using the Salmonella enterica trimeric autotransporter SadA and the structurally similar YadA protein of Yersinia spp., we identify the importance of BamA and BamD in the biogenesis of the trimeric autotransporters and reveal that BamB, BamC, BamE, TamA and TamB are not required for secretion of functional passenger domain on the cell surface.ImportanceThe secretion of trimeric autotransporters (TAA’s) has yet to be fully understood. Here we show that efficient secretion of TAAs requires the BamA and D proteins, but does not require BamB, C or E. In contrast to classical autotransporter secretion, neither trimeric autotransporter tested required TamA or B proteins to be functionally secreted.