bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of the HW with MSHF Investigations to Manage the Development of Low-Permeability Reservoirs
Authors: Shurunov Andrey , Sheremeev Alexander , Kaeshkov Ilya , Kolesnikov Mikhail , Bikkulov Marcel , Uchuev Ruslan , Solodov Sergey , Islamov Ruslan , Saitgareev Ilmir 
Published: August 2021

Abstract
The active building of HW with MSHF use for ensuring their effective development in low-permeability reservoirs, but there are certain difficulties with getting completely information for making the right decisions during control of development.
As part of the work performed, the main uncertainties and the further application of research results for estimates the profile of horizontal well (HW) with multi-stage hydraulic fracturing (MSHF) for planning the necessary geological and technical actions based on more than 20 operations at the South Priobskoye field are shown.
The following field geophysical tests were executed in wells: PLT with Y-tool and CT + spectral noise logging module;PLT during compression with CT + multi-sensor flow meter;PLT with a well tractor;tracer studies (proppant, frac sleeves);thermometry with using fiber-optic system in injection and production wells.
Detection of the Communication Site by Indocyanine Green Adsorbed to Human Serum Albumin Fluorescence During Surgery for a Pleuroperitoneal Communication
Authors: Kimura Daisuke , Fukuda Ikuo , Fujita Takeshi , Murakami Reiichi , Nakamura Norio , Song Cheng-Yang , Kuriyama Shoji , Sakai Takehiro , Tsushima Takao 
Published: August 2021

Abstract
A pleuroperitoneal communication is a serious complication for patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Video-assisted thoracoscopic surgery is performed using indocyanine green adsorbed to human serum albumin fluorescence to identify the communication because human serum albumin reinforces fluorescence images. A patient diagnosed with a pleuroperitoneal communication was referred to our department and underwent surgery. To detect the communication, a dialysate mixture that contained indocyanine green and human serum albumin was injected from the CAPD catheter. Real-time fluorescence images were able to clearly show a bleb-like lesion with a near-infrared spectroscopy camera, and the site was repaired. The patient had no recurrence at one-year follow-up. This method might be good method for pleuroperitoneal communication surgery.
Genotype by Environment Interaction by AMMI and GGE Bi-Plot Analysis for Maize (Zea Mays L.) for Transitional High Land Agroecology of Ethiopia.
Authors: Getachew Gemechu , Abebe Beyene , Chelchisa Deselegn , Oli Sara , Chebsa Temesgen , Tefa Zelalem , Guban Bedlu , Ngozi Abu 
Published: August 2021

Abstract
The current research examined the magnitude of genotype by environment interaction (G x E) and evaluated the adaptability and stability of maize genotypes for grain yield in Ethiopia's transitional highland agroecology using an additive main effects and multiplicative interaction (AMMI) model. The study's goals were to first assess the yield output and stability of maize genotypes in Ethiopia's transitional highlands, and then to investigate the effect of genotype- environment interaction on genotype yield. During the main season of 2017/2018, thirteen advanced maize genotypes which was selected from different observation trials with two commercial check hybrids were evaluated at five representative locations for agroecology. The experiment was set up using an alpha lattice (3*5) with three replications and two rows per plot. AMMI showed highly significant(P < 0.001) variation of grain yield was observed due to the effect of genotype (G), Environment(E) and their interaction (G x E). In fact, all genotypes evaluated in representative locations for this agroecology had higher grain yield advantages than the best commercial check except one genotype. Overall, this study discovered the possibility of fast releasing and overtake of new maize hybrids for transitional high land agroecology of Ethiopia to exploits availability maize germplasm to maximize production. The best candidate genotype, MABK181261 is a stable and high-yielding product. It is recommended for release as a commercial hybrid alternative after national variety verification trial in a high land transitional agroecology of Ethiopia. In addition, the parental lines of this genotypes can be used to enhance germplasm of opposite heterotic group in maize breeding for East Africa.
Optical Modulator using Ultra-Thin Silicon Waveguide in SOI Hybrid Technology
Authors: Ayoub Ahmed B. , Swillam Mohamed 
Published: August 2021

Abstract
We propose a detailed study of an on-chip optical modulator using a non-conventional silicon-based platform. This platform is based on the optimum design of ultra-thin silicon on insulator (SOI) waveguide. This platform is characterized by low field confinement inside the core waveguide and high sensitivity to the cladding index. Accordingly, it lends itself to a wide range of applications, such as sensing and optical modulation. By employing this waveguide into the Mach-Zehnder interferometer (MZI) configuration, an efficient optical modulator is reported using an organic polymer as an active material for the electro-optic effect. An extinction ratio of more than 20 dB is achieved with energy per bit of 13.21 fJ/bit for 0.5 V applied voltage. This studied platform shows promising and adequate performance for modulation applications. It is cheap and easy to fabricate.
Effects of Diets Containing Beta-Glucan on Survival, Growth Performance, Hematological, Immunity and Biochemical Parameters of Rainbow Trout (Oncorhynchus Mykiss) Fingerlings
Authors: Khanjani Mohammad Hossein , Ghaedi Gholamreza , Sharifinia Moslem 
Published: August 2021

Abstract
This study aimed to investigate the effect of beta-glucan in rainbow trout’s diet on survival, growth performance, hematological, immunity and biochemical parameters. Rainbow trout (Oncorhynchus mykiss) with an average weight of 6.35 ± 0.09 were stocked in 30 fiberglass tanks with a volume of 200 liters. Four treatments including: control group (0%), 0.5, 1 and 2% of beta-glucan were considered for 8 weeks. The results showed that the survival and growth performance of rainbow trout in the control group were at the lowest level and showed a significant difference with other treatments. The highest percentage of hematocrit (47.9%), white blood cell count, neutrophil percentage (35.2%) was observed in the treatment with 2% beta-glucan. Also, the highest lysosomal activity (59.7 units’ mL− 1, IgM (54.7 mg dL− 1), C3 and C4 was obtained in 2% beta-glucan treatment. Biochemical parameters showed improvement in treatments fed with 1 and 2% beta-glucan. In general, the present study showed that 2% beta-glucan in the diet of rainbow trout improves growth performance, survival, hematological, immunity and biochemical parameters.
Associations of Prematurity and Low Birth Weight With Blood Pressure and Kidney Function in Middle-aged Participants of the Brazilian Longitudinal Study of Adult Health – ELSA-Brasil
Authors: Branda Julia Ines F. , Almeida-Pititto Bianca , Bensenor Isabela , Lotufo Paulo A. , Ferreira Sandra Roberta G. 
Published: August 2021

Abstract
BackgroundBased on the Developmental Origins of Health and Disease, adverse intrauterine environment – reflected by low birth weight (LBW) and prematurity – may induce fetal programming that favors kidney dysfunction in adulthood. We examined the association of LBW and prematurity with blood pressure (BP) and kidney function markers in non-diabetic middle-aged adults without kidney disease from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). MethodsA cross-sectional analysis of 768 subjects aged 35-54 years was conducted. Comparisons were performed according to birth weight: LBW (<2.5 kg) or normal birth weight (NBW) (2.5-4.0 kg). Associations of LBW and prematurity with BP levels and kidney function markers (glomerular filtration rate - eGFR, albumin-creatinine ratio - ACR and serum cystatin C) were tested by multiple linear regression using adjustments based on Directed Acyclic Graphs. Propensity score matching was applied to control imbalances. ResultsMean age of participants was 45.5 ± 4.6 years and 56.8% were female; 64 (8.3%) participants reported LBW and 39 (5.0%) prematurity. The LBW group had higher systolic (p = 0.015) and diastolic BP (p = 0.014) and ACR values (p = 0.031) and lower eGFR (p = 0.015) than the NBW group, but no group difference for serum cystatin C was found. The preterm group had higher mean levels of systolic and diastolic BP, but no difference in kidney function markers was evident. In a regression model adjusted for sex, skin color and family history of hypertension, both systolic and diastolic BP levels were associated with LBW, but this association disappeared after adding prematurity, which remained associated with BP (p = 0.017). Having applied propensity score matching, LBW was associated with ACR values (p=0.003), but not with eGFR or BP levels. ConclusionThe study findings of independent associations of prematurity with higher BP levels, and of LBW with markers of kidney function, in adulthood support that early life events predict risk for hypertension and kidney dysfunction in adulthood. The study design precluded the inferring of causality, and prospective studies are needed to further investigate the hypothesis raised.
Needs Assessment In Patients Surgically Treated For Head And Neck Cancer – A Randomized Controlled Trial
Authors: Mortensen Annelise , Wessel Irene , Rogers Simon Neave , Tolver Anders , Jarden Mary 
Published: August 2021

Abstract
Purpose:Investigate whether a head and neck cancer specific needs assessment tool integrated in nursing rehabilitation consultations early in the post-surgical period would improve quality of life and symptom burden in patients surgically treated. Further, to assess the feasibility of carrying out needs assessments during consultations. Methods:92 surgically treated head and neck cancer patients at the Department of Otolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital, Denmark were enrolled. A two-arm randomized controlled trial design was used. Both arms received nursing rehabilitation consultations before discharge, approximately two weeks and two months post-operative. Patients in the intervention group had their needs assessed using an assessment tool.Primary outcome was quality of life. Secondary outcomes were symptom burden and referrals for multi-disciplinary rehabilitation follow-up. Results:No significant differences were found in quality of life or symptom burden. However, notable more patients in the intervention group were referred for rehabilitation. Conclusion:The intervention suggests that important needs were identified and addressed, especially emotional and existential needs, which were accommodated through referrals and professional advice. Nursing rehabilitation consultations using a needs assessment instrument may ensure that patient preferences and priorities are incorporated in their care. Trial RegistrationClinicalTrials.com (NCT03443258). Date of registration: May 31st, 2018
Gastric Polyps: A 10-Year Analysis Of 18496 Upper Endoscopies
Authors: Yacoub Haythem , Bibani Norsaf , Sabbah Mériam , Bellil Nawel , Ouakaa Asma , Trad Dorra , Gargouri Dalila 
Published: August 2021

Abstract
Background/Aims: Gastric polyps (GPs) are usually asymptomatic lesions of the upper gastrointestinal tract observed in 1-3% of esophagogastroduodenoscopies (EGD). The majority of polyps are benign. The aim of this study was to precise the frequency of different types of gastric polyps in our population, and to analyze their possible association with other factors.Materials and Methods: A total of 18496 consecutive patients undergoing EGD over a ten-year period (between 2007 and 2018) in a tertiary hospital were retrospectively reviewed. Eighty-six patients diagnosed with gastric polyps were analysed. Demographics, medical history of the patients, and indication for gastroscopy were collected. Morphological, histological characteristics of polyps, and therapeutic management data were also collected.Results: GPs were found in 86 out of 18496 (0.46%) reviewed EGD, corresponding to a total of 141 polyps. There were 64 female (74.4%) and 22 male patients (25.6%) with a sex ratio (M/F) of 0.34. The average age was 58.1 years. One hundred and forty one polyps were included, and histopathology was obtained on 127 GPs. The most common location was the fundus (59.6%) and 48.9% were smaller than 5 mm. The polyp was unique in 75.6% of cases. According to Paris classification, 80% of the polyps were sessile (Is). Hyperplastic polyps were the most common (55.9%) were hyperplastic polyps, followed by sporadic fundic gland polyps in 23 patients (18.1%), 7 (5.5%) were adenomas, and 4 (3.1%) were neuroendocrine tumors type 1. The following factors were associated with hyperplastic polyps: anemia (p= 0.022), single polyp (p= 0.025) and size ≥ 5mm (p= 0.048). Comparing hyperplastic polyps biopsies to resected polyps, no difference was found in the evolutionary profile of the 2 groups. A size less than 10 mm (p=0.013) was associated with fundic gland polyps. Sixty polyps (47.2%) were treated by cold forceps, 19 (15%) treated by a mucosal resection and 15 (11.8%) with diathermic snare. Five procedural bleeding incidents were observed (3.9%). Only the use of anticoagulant treatment was associated with a high bleeding risk (p= 0.005). The comparative histological study between specimens of biopsied GPs and endoscopic polypectomy led to an overall agreement of 95.3%.Conclusion: In our study, the GPs frequency was 0.36%. Hyperplastic polyps and fundic gland are the most common gastric polyps in our country. The high frequency of Helicobacter pylori infection in our patients and in our area may explain the high frequency of HP.
A Combination of Bone Marrow Mesenchymal Stem Cells with Estrogen Improves Rabbit Endometrial Injury Repair by a Mechanism Involved in an Activation of Wnt/β-catenin Signaling
Authors: Liwei Yuan , Jia Cao , Mingyue Hu , Dabao Xu , Yan Li , Shiyun Zhao , Juanjuan Yuan , Huixing Zhang , Yani Huang , He Jin , Meixia Chen , Liu Dan 
Published: August 2021

Abstract
Background: Although the effect of bone marrow mesenchymal stem cells (BMSCs) combined with estrogen therapy in the repair of endometrial injury has been confirmed, its underlying molecular mechanism in intrauterine adhesion (IUA) remains unclear. In this study, we aim to investigate the effect and involvement of a combination of BMSCs with estrogen in restoration of injured endometrium by applying a rabbit endometrial injury model. Method: BMSCs were isolated and labeled with PKH26 fluorescent dye. The IUA animal model was generated by a dual damage method of mechanical curettage and lipopolysaccharide infection. Rabbits were randomly assigned to the following 5 groups: sham operation group, IUA model group, E2 treatment group, BMSCs treatment group, and BMSCs combined with E2 treatment group. Bilateral uterus were obtained at different time points for the further study. HE and Masson staining were used to evaluate the number of endometrial glands and the degree of fibrosis. The expression of fibrosis and EMT related markers were observed by Immunohistochemical, immunofluorescence staining and Western blot. The expression of core molecules in the Wnt/β-catenin signaling pathway was examined by Western blot.Results: In the present study, it is found that PKH26 fluorescent dye can successfully label BMSCs and track the distribution and differentiation of transplanted BMSCs. BMSCs differentiated into endometrial epithelial cells and mainly located around the endometrial glands and extracellular matrix at 3 or 5 days post-transplantation, while BMSCs primarily differentiated into endometrial stromal cells at 7 days after orthotopic transplantation. Furthermore, after combined treatment of BMSCs and estrogen, the number of glands increased significantly, and the area of fibrosis reduced evidently, accompanied by a downregulation of mesenchymal markers and upregulation of epithelial markers when compared with each single treatment group. The expression levels of core molecules in the Wnt/β-catenin signaling pathway were higher in the BMSCs+E2 group than in the other treatment groups. Conclusions: Our study demonstrates that BMSCs combined with estrogen can improve the repair after endometrial injury by promoting the proliferation of endometrial epithelial cells and inhibiting EMT and endometrial fibrosis. This combined effect is achieved in part through activation of the Wnt/β-catenin signaling pathway.
Under-specification as the Source of Ambiguity and Vagueness in Narrative Phenotype Algorithm Definitions
Authors: Yu Jingzhi , Pacheco Jennifer A. , Ghosh Anika , Luo Yuan , Weng Chunhua , Shang Ning , Benoit Barbara , Carrell David , Carroll Robert , Dikilitas Ozan , Freimuth Robert , Gainer Vivian , Hakonarson Hakon , Hripcsak George , Kullo Iftikhar , Mentch Frank , Murphy Shawn , Peissig Peggy , Ramirez Andrea , Walton Nephi , Wei Wei-qi , Rasmussen Luke 
Published: August 2021

Abstract
IntroductionCurrently, one of the commonly used methods for disseminating electronic health record (EHR)-based phenotype algorithms is providing a narrative description of the algorithm logic, often accompanied by flowcharts. A challenge with this mode of dissemination is the potential for under-specification in the algorithm definition, which leads to ambiguity and vagueness. MethodsThis study examines incidents of under-specification that occurred during the implementation of 34 narrative phenotyping algorithms in the electronic Medical Record and Genomics (eMERGE) network. We reviewed the online communication history between algorithm developers and implementers within the Phenotype Knowledge Base (PheKB) platform, where questions could be raised and answered regarding the intended implementation of a phenotype algorithm. ResultsWe developed a taxonomy of under-specification categories via an iterative review process between two groups of annotators. Under-specifications that lead to ambiguity and vagueness were consistently found across narrative phenotype algorithms developed by all involved eMERGE sites. Discussion & ConclusionOur findings highlight that under-specification is an impediment to the accuracy and efficiency of the implementation of current narrative phenotyping algorithms, and we propose approaches for mitigating these issues and improved methods for disseminating EHR phenotyping algorithms.
Assessment of 5-Year Outcomes of Life Satisfaction in Acute Respiratory Distress Syndrome Survivors After Rehabilitation Programs: A Prospective, Multicenter, Randomized Controlled Trial
Authors: Rahimi-Bashar Farshid , Salesi Mahmood , Gohari-Moghadam Keivan , Pourhoseingholi Mohamad Amin , Vahedian_Azimi Amir 
Published: August 2021

Abstract
The use of rehabilitation program for survivors of Acute Respiratory Distress Syndrome (ARDS) could be one of the important and fundamental steps to improve the pulmonary function and health related quality of life (HRQoL) of patients. This study was carried out to evaluate the effect of two rehabilitation techniques (Family-Based Empowerment Model (FECM)/Continuing Care Model (CCM), or both of them) on pulmonary function and HRQoL in ARDS survivor. From December 2009 to October 2014, ARDS survivors from mixed medical-surgical ICUs at four academic teaching hospitals in Tehran, Iran, randomly assigned to one of three intervention groups (A, B or C) or a control group (D). Pre- and post-interventions, pulmonary functions and HRQoL status of patients in all groups were collected 48 times through clinical measurements and various questionnaires during 5 years of follow-up. Significantly improvement was seen in the intervention groups compared to the control group, and the greatest benefit was observed in patients that received mixed of FCEM and CCM rehabilitation techniques. Co-administration of FCEM and CCM can improve pulmonary function as well as the life satisfaction of ARDS survivors. As a result, the execution of the empowerment model by nurses is recommended for ARDS survivors and the participation of their families at the same time. Trial registration: NCT02787720 (ClinicalTrial.gov, 01/06/2016).
Nanoliposome-encapsulated Phenolic Rich Fraction From Alcea Rosea as a Dietary Phytobiotic in Mice Challenged by Escherichia Coli
Authors: Hassirian Niloofar , Karimi Ehsan , Oskoueian Ehsan 
Published: August 2021

Abstract
Background: This research was performed to evaluate the antibacterial and health-promoting potentials of the nanoliposome-encapsulated phenolic rich fraction (PRF) from Alcea rosea leaves as a dietary phytobiotic in mice challenged by enteropathogenic Escherichia coli (E. coil; O157: H7). Results: The overall results demonstrated that the nanoliposome-loaded PRF contained gallic acid, salicylic acid, pyrogallol, cinnamic acid, catechin, naringin, ferulic acid. The E. coil challenge in mice impaired the weight gain, food intake, liver enzymes, lipid peroxidation, morphometric characteristics of the ileum, up-regulated the inflammatory genes (COX2, iNOS), down-regulated the antioxidant-related genes (SOD and GPx) and increased the population of E. coil in the ileum. The dietary inclusion of nonencapsulated PRF and nanoliposome-encapsulated PRF at the concentration of 10 mg TPC/kg BW/day improved these parameters however the nanoliposome-encapsulated PRF appeared to be more effective as compared to nonencapsulated PRF in improving the health parameters in mice. Conclusion: Consequently, the nanoliposome-encapsulated PRF could play a critical role as a promising phytobiotic against E. coil infection in mice.