bluuebunny/crossref_metadata_2025_split huggingface dataset:
The clinical utility of procainamide‐induced late potentials on the signal averaged ECG
Authors: Pearman Charles Michael , Walia Jagdeep , Alqarawi Wael , Larsen Jacob Moesgaard , Leach Emma , Krahn Andrew D. , Laksman Zachary 
Published: October 2021

AbstractBackgroundLate potentials (LPs) identified on the signal averaged electrocardiogram (SAECG) are a marker for an increased risk of arrhythmias in Brugada syndrome (BrS). Procainamide is a sodium channel blocker used to diagnose BrS. The effects of Procainamide on the SAECG in those with BrS and the significance of Procainamide‐induced LPs are unknown.MethodsProcainamide provocation was performed for suspected BrS with 12‐lead and SAECG pre‐ and post‐infusion. Filtered QRS duration (fQRSd), duration of low amplitude signals <40 μV (LAS40) and root‐mean‐square voltage in the terminal 40 ms (RMS40) were determined.ResultsData from 150 patients were included in the analysis (mean age 44.5 years, 109 males). Procainamide increased fQRSd (Pre 118.8 ± 10.5 ms, post 121.2 ± 10.2 ms, p < 0.001) and LAS40 (Pre 38.7 ± 9.8 ms, post 40.2 ± 10.5 ms, p = 0.005) and decreased RMS40 (Pre 24.6 ± 12 ms, post 22.8 ± 12 ms, p = 0.002). LPs were present in 68/150 (45%) at baseline. Fifteen patients with negative baseline SAECGs had LPs unmasked by Procainamide, but six patients had LPs at baseline that were no longer present following Procainamide. Comparing those with normal hearts (n = 48) to those with a final diagnosis of BrS (n = 38), Procainamide prolonged fQRSd to a greater extent in those with BrS. Comparing those with Procainamide‐induced LPs to those with no LPs at any time did not highlight any aspect of phenotype and did not correlate with a history of ventricular arrhythmias.ConclusionsProcainamide influences the SAECG, provoking LPs in a small proportion of patients. However, there is no evidence that Procainamide‐induced LPs provide additional diagnostic information or aid risk stratification.
Recruiting custodial grandmothers using Facebook
Authors: Clark Karen C. , Kelley Susan J. , Clark Patricia C. 
Published: October 2021

AbstractObjectivesRecruitment through Facebook is gaining favor as an approach for research, including clinical trials, because of the platform's ability to reach broad and diverse populations. As older adults increase their social media use, recruitment through Facebook has become a viable option. The purposes of this paper are to report the methodological process and lessons learned from recruiting custodial grandmothers (CGMs) for a cross‐sectional study examining parenting self‐efficacy and psychological well‐being.ParticipantsA total of 113 people consented and accessed the survey online, with 40 (35.4%) completing surveys. The final sample comprised 68 grandmothers, with 59% recruited via Facebook.MethodsFacebook recruitment for the online survey included creating a dedicated Facebook study page, accessing existing Facebook pages for custodial grandparents, and using paid advertising. Face‐to‐face recruitment strategies also were used with paper surveys.ResultsWe compared the characteristics of those completing online surveys versus paper surveys. CGMs completing the survey online were significantly younger and more likely to be Caucasian than those completing the paper survey.ConclusionsFindings indicated online recruitment via Facebook is an advantageous method to reach CGMs. However, additional research is needed to determine if other online and social media platforms would be useful in recruiting this population.
Updating incoherent credences ‐ Extending the Dutch strategy argument for conditionalization
Authors: De Bona Glauber , Staffel Julia 
Published: October 2021

AbstractIn this paper, we ask: how should an agent who has incoherent credences update when they learn new evidence? The standard Bayesian answer for coherent agents is that they should conditionalize; however, this updating rule is not defined for incoherent starting credences. We show how one of the main arguments for conditionalization, the Dutch strategy argument, can be extended to devise a target property for updating plans that can apply to them regardless of whether the agent starts out with coherent or incoherent credences. The main idea behind this extension is that the agent should avoid updating plans that increase the possible sure loss from Dutch strategies. This happens to be equivalent to avoiding updating plans that increase incoherence according to a distance‐based incoherence measure.
Why do firms import via merchants in entrepôt countries rather than directly from the source?
Authors: Medin Hege 
Published: October 2021

AbstractUsing Norwegian import‐transactions data, this article studies which factors are associated with the probability of importing indirectly via third countries (entrepôts), rather than directly from the source. Source country characteristics—especially high trade barriers and unfavorable geographical locations—are important when time‐invariant unobserved heterogeneity is not controlled for. When controlling for this, however, firm‐ and product‐level characteristics stand out as the main drivers. Smaller and less productive firms more often import via entrepôts, especially when importing product‐source combinations that are relatively unimportant in their total imports and when importing products with low price dispersion and high value‐to‐weight ratios.
Effectiveness of kinesiotaping in patients with subacromial impingement syndrome: A systematic review with meta‐analysis
Authors: Araya‐Quintanilla Felipe , Gutiérrez‐Espinoza Héctor , Sepúlveda‐Loyola Walter , Probst Vanessa , Ramírez‐Vélez Robinson , Álvarez‐Bueno Celia 
Published: October 2021

ObjectiveTo determine the effectiveness of kinesiotaping (KT) with or without co‐interventions for clinical outcomes in patients with subacromial impingement syndrome (SIS).DesignSystematic review with meta‐analysis of randomized clinical trials.Data sourcesEight databases (MEDLINE, CENTRAL, EMBASE, PEDro, LILACS, CINAHL, SPORTDiscus, and Web of Science) were searched from inception until March 2021.Eligibility criteria for selecting studiesClinical trials that determine the effectiveness of KT with or without co‐interventions for clinical outcomes in patients with SIS who are older than 18 years of age.ResultsTen trials for the quantitative analysis were included. For pain intensity at 1–3 weeks, the overall pooled MD was −0.73 cm, 95% CI = −1.50 to 0.04 (p = 0.06), and at 3–6 weeks, it was −0.13 cm, 95% CI = −1.37 to 0.36 (p = 0.25). For shoulder function, the MD was −0.02, 95%CI = −0.30 to 0.26 (p = 0.89). For shoulder Range of Motion (ROM) flexion, the MD was −16.70, 95% CI = −0.52 to 33.92 (p = 0.06). Additionally, there was a low to moderate quality of evidence according to the GRADE rating.ConclusionKinesiotaping with or without co‐interventions was not superior to other interventions for improving shoulder pain intensity, function and ROM flexion in patients with SIS.
A prospective, multi‐centre, Veterinary Radiation Therapy Oncology Group study reveals potential efficacy of toceranib phosphate (Palladia) as a primary or adjuvant agent in the treatment of canine nasal carcinoma
Authors: Ehling Tara Jean , Klein Mary Kay , Smith Lauren , Prescott Deborah , Haney Siobhan , Looper Jayme , LaDue Tracey , Brawner William , Fidel Janean , Shiomitsu Keijiro , Green Eric , Saba Corey , Turek Michelle , Farrelly John 
Published: October 2021

AbstractRadiation is the standard of care for dogs with nasal tumours. The addition of another therapy that could improve outcome without increasing toxicity is attractive. Medical therapy that could offer better outcome than maximally tolerated dose chemotherapy when radiation therapy (RT) is not possible or is declined is also attractive. This article reports the findings from a prospective, multi‐centre, non‐randomized, Veterinary Radiation Therapy Oncology Group clinical trial designed to evaluate whether toceranib phosphate (toceranib) has primary activity and if the addition of toceranib to RT could positively impact outcome. Owner's discretion determined enrolment in toceranib alone or toceranib + RT arm. Historical controls for radiation alone were selected from patients treated with identical RT and imaging protocols. Responses were evaluated with pre‐treatment and week‐16 CT scans. RT total dose of 42 Gy was completed in 10 fractions. Sixty‐three dogs enrolled from 10 study sites. Overall response rates (CR + PR) were significantly improved in the toceranib + RT (79.4%) and RT alone (68.9%) arms over toceranib alone (22%) (p = .011). Clinical benefit rates (CR + PR + SD) were significantly improved in the toceranib + RT arm over the RT alone arm at 97.3% and 79.2% respectively (p = .036). Treatment with toceranib alone, toceranib + RT and RT alone resulted in median survival times of 298, 615 and 368 days respectively, but were not statistically significantly different (p = .0502). Adverse events associated with toceranib administration did not potentiate the RT side effect profile. Toceranib appears to have primary activity against nasal carcinoma.
Microstructural Evolution of Viscoelastic Properties of Underfills Under Sustained High Temperature Operation
Authors: Lall Pradeep , Kasturi Madhu , Wu Haotian , Suhling Jeffrey C. , Davis Edward 
Published: October 2021

Abstract
Automotive underhood electronics are subjected to high operating temperatures in the neighborhood of 150 to 200? for prolonged periods in the neighborhood of 10-years. Consumer grade off-the shelf electronics are designed to operate at 55 to 85? with a lower use-life of 3 to 5 years. Underfill materials are used to provide supplemental restraint to fine-pitch area array electronics and meet the reliability requirements. In this paper, a number of different underfill materials are subjected to automotive underhood temperatures to study the effect of long time isothermal exposure on microstructure and dynamic-mechanical properties. It has been shown that isothermal aging oxidizes the underfill, which can change the mechanical properties of the material significantly. The oxidation of underfill was studied experimentally by measuring oxidation layer thickness using polarized optical microscope. The effect on the mechanical properties was studied using the dynamic mechanical properties of underfill with DMA (Dynamic Mechanical Analyzer). Two different underfill materials were subjected to three different isothermal exposure, which are below, near and above the glass transition temperature of the underfills. The dynamic mechanical viscoelastic properties like storage modulus, loss modulus, tan delta and their respective glass transition temperatures were investigated. Three point bending mode was used in the DMA with a frequency of 1 Hz operating at 3?/min.
Analysis, Design, and Validation of a Vaned Diffuser for Improved Fish Friendliness
Authors: Pan Qiang , Shi Weidong , Zhang Desheng , Van Esch B. P. M. 
Published: October 2021

Abstract
The primary cause of mechanical-related fish injury and mortality in turbomachinery is blade strike. Fish contained in the flow may strike with the rotor blades and the fixed diffuser vanes, the latter being a non-negligible factor causing fish damage in the pump system. In this study, an experiment-based correlation of fish mutilation ratio acts as critical strike velocity. The relation between strike damage in a vaned diffuser and the theoretical pump head is presented as a function of specific speed. As an example, a vaned diffuser is designed for a single-bladed, mixed-flow impeller with the purpose of improving fish friendliness. This pump can be scaled to operate with a head up to 14 m at peak efficiency, without fish damage in the diffuser. Subsequently, experiments are conducted to show the retained pump performance as well as the great improvement of fish friendliness.
Experimental Investigation of Aerostatic Journal Bearings Made of Carbon Fiber-Reinforced Carbon Composites
Authors: Schimpf Artur , Ortelt Markus , Seiler Helge , Gu Yandong , Schwarzwälder Alexander , Böhle Martin 
Published: October 2021

Abstract
This study describes experimental results using carbon fiber-reinforced carbon (C/C) material for porous journal bearings under static conditions. Exerted radial forces of up to 90 N, a supply pressure of up to 6 bar, and a maximum rotational speed of 8000 rpm were tested. The occurrence of pneumatic hammering was not observed under these operating points. Triangulation sensors were mounted vertically and horizontally as well as in front of and behind the tested bearing. These sensors measure the eccentricity and misalignment. The orbit analysis demonstrated an improvement in concentricity with an increment in the supply pressure. The layered structure of the C/C material used for the porous liner is presented. A rotational speed below 8000 rpm negligibly influenced the load-carrying capacity and the flowrate. The vertical misalignment of the shaft was determined in relation to the force-applied test bearing. In addition, two vertically positioned sensors on the support-bearing housing were used to discern the misalignment in the absolute system. On the other hand, reducing the speed to 1000 rpm increased the concentricity error. The shaft showed no significant signs of use after the experiments. The measurements confirm the suitability of the material for porous bearings.
Locally Resonant Effective Phononic Crystals for Subwavelength Vibration Control of Torsional Cylindrical Waves
Authors: Arretche Ignacio , Matlack Kathryn H. 
Published: October 2021

Abstract
Locally resonant materials allow for wave propagation control in the subwavelength regime. Even though these materials do not need periodicity, they are usually designed as periodic systems since this allows for the application of the Bloch theorem and analysis of the entire system based on a single unit cell. However, geometries that are invariant to translation result in equations of motion with periodic coefficients only if we assume plane wave propagation. When wave fronts are cylindrical or spherical, a system realized through tessellation of a unit cell does not result in periodic coefficients and the Bloch theorem cannot be applied. Therefore, most studies of periodic locally resonant systems are limited to plane wave propagation. In this article, we address this limitation by introducing a locally resonant effective phononic crystal composed of a radially varying matrix with attached torsional resonators. This material is not geometrically periodic but exhibits effective periodicity, i.e., its equations of motion are invariant to radial translations, allowing the Bloch theorem to be applied to radially propagating torsional waves. We show that this material can be analyzed under the already developed framework for metamaterials. To show the importance of using an effectively periodic system, we compare its behavior to a system that is not effectively periodic but has geometric periodicity. We show considerable differences in transmission as well as in the negative effective properties of these two systems. Locally resonant effective phononic crystals open possibilities for subwavelength elastic wave control in the near field of sources.
The Workings of a Renal Unit
Authors: Hedger N. A. 
Published: October 2021

AbstractThis article describes the work of a large Regional Renal Unit. A background to the structure and logistics of such a unit is given along with the type of patients it receives and therapies it can offer. Renal Replacement Therapy (RRT) is briefly described, as are the problems associated with it. The aim is to de-mystify the workings of a renal unit and to provide some advice concerning its use by non-nephrologists.
Royal British Legion War Grave Pilgrimages: A Medical Escort’s Perspective
Authors: Richardson J. C. 
Published: October 2021

SummaryThe Royal British Legion organises pilgrimages to nearly all parts of the world where British servicemen and servicewomen and their allies fought and died. The Pilgrimage Department has taken thousands of widows, other relatives, veterans and friends to visit the grave of a loved one or comrade buried overseas. The parties of pilgrims are escorted by Service medical officers and nurses of the Regular and Reserve Armed Forces. The role of the medical escort is described.
Middle term results of a cementless threaded self-tapping acetabular cup
Authors: Pandit H. G. , Hand C. J. , Ramos J. L. , Pradham N. S. , Boyd N. A. 
Published: October 2021

AbstractVarious designs of acetabular cup are available for cementless fixation in patients undergoing total hip arthroplasty. Conflicting results have been reported in the literature about the middle to long term outcomes with the use of these cups. We present our experience of a design of self-tapping threaded acetabular cup with metal backing (the ACSYS acetabular cup). This is a study of 41 hips with average follow up of 6.43 years. Functional grading of the hips was very satisfactory and none of the patients needed revision for aseptic loosening. No case of significant cup migration or osteolysis was noted. The paper also reviews the literature.
Heat strain in Royal Navy helicopter aircrew
Authors: House J. R 
Published: October 2021

AbstractA review of the literature on heat strain and aircrew and a questionnaire survey of Royal Navy aircrew have been completed. Aircrew appreciate, some 50% from first hand experience, that heat strain can reduce their operational endurance and performance. They are at greatest risk of developing it in the pre-flight period, especially when wearing Nuclear, Biological, or Chemical (NBC) protective equipment. Several techniques they use to reduce this risk are described. Some may be of particular assistance in the field should air conditioned facilities be unavailable. However, opportunities to improve the thermal environment within the aircraft on the ground and in flight are limited as the heat generated within it and high levels of solar radiation impinging on it severely challenge air conditioning units, themselves constrained by weight and size. Other demands placed on protective clothing offer little potential to increase the rate at which aircrew can lose accumulated heat. It is concluded that an appropriate micro-climate cooling system worn next to the skin may be required to achieve truly significant reductions in heat strain. Research at the Institute of Naval Medicine has identified liquid cooling techniques which may be suitable for aircrew in all but the smallest helicopters.Any views expressed are those of the author and do not necessarily represent those of the Department.
Normative blood pressure response to exercise stress testing in children and adolescents
Authors: Clarke Melanie M , Zannino Diana , Stewart Natalie P , Glenning Jonathan P , Pineda-Guevara Salvador , Kik Jolien , Mynard Jonathan P , Cheung Michael M H 
Published: October 2021

ObjectiveTo describe normative values for blood pressure (BP) response to maximal exercise in children/adolescents undergoing a treadmill stress test.MethodsFrom a retrospective analysis of medical records, patients who had undergone a Bruce protocol exercise stress test, with (1) normal cardiovascular system and (2) a body mass index percentile rank below 95% were included for analysis. Sex, age, height, weight, resting and peak heart rate, resting and peak systolic blood pressure (SBP), test duration, stage of Bruce protocol at termination, reason for undergoing the test and reason for termination of test were collected. Percentiles for exercise-induced changes in SBP were constructed by age and height for each sex with the use of quantile regression models.Results648 patients with a median age of 12.4 years (range 6–18 years) were included. Typical indications for stress testing were investigation of potential rhythm abnormalities, syncope/dizziness and chest pain and were deemed healthy by an overseeing cardiologist. Mean test duration was 12.6±2.2 min. Reference percentiles for change in SBP by sex, age and height are presented.ConclusionThe presented reference percentiles for the change in SBP for normal children and adolescents will have utility for detecting abnormally high or low BP responses to exercise in these age groups.
Metallo-beta-lactamase-producing Escherichia coli in the sewage of Mexico City: where do they come from?
Authors: Lüneberg Kathia , Amábile-Cuevas Carlos F. , Mucito-Varela Eduardo , Martínez Leticia , Salinas Eva , López-Vidal Yolanda , Siebe Christina , Rosas Irma 
Published: October 2021

While monitoring the presence of antibiotic resistance in municipal wastewater bacteria from Mexico City, five Escherichia coli isolates were found to be resistant to carbapenems, antibiotics of “last resort” used mostly in hospitals. Further analysis revealed that these carbapenem-resistant isolates carried the gene encoding a metallo-beta-lactamase, NDM-5. The gene was found to be beared by a large, ∼145 kb conjugative plasmid, which also carries putative genes encoding resistance to sulfonamides, trimethoprim, tetracycline, ciprofloxacin, and chloramphenicol (although no phenotypic chloramphenicol resistance was detected) and quaternary-ammonium compounds. The plasmid also carried gene mobility determinants, such as integron integrase and two transposases. In addition to the direct public health threat posed by the presence of such multi-resistant organisms in wastewater released into the environment and used for crop irrigation; it is particularly concerning that carbapenem-resistant E. coli is rather rare in Mexican hospitals (<1%), but was found in small, 100 mL samples of municipal wastewater. This suggests that these organisms are under-reported by clinical microbiology laboratories, underlining the usefulness of wastewater monitoring, or that there is an unknown source of such carbapenem-resistant organisms that are being dumped into the wastewater. The source of these bacteria must be assessed and controlled to prevent further spread of this multi-resistance plasmid among other environmental and clinical microorganisms.
Sensitivity to triple Higgs couplings via di-Higgs production in the 2HDM at $$e^+e^-$$ colliders
Authors: Arco F. , Heinemeyer S. , Herrero M. J. 
Published: October 2021

AbstractAn important task at future colliders is the investigation of the Higgs-boson sector. Here the measurement of the triple Higgs coupling(s) plays a special role. Based on previous analyses, within the framework of Two Higgs Doublet Models (2HDM) type I and II, we define and analyze several two-dimensional benchmark planes, that are over large parts in agreement with all theoretical and experimental constraints. For these planes we evaluate di-Higgs production cross sections at future high-energy $$e^+e^-$$

e
+

e
-

colliders, such as ILC or CLIC. We consider two different channels for the neutral di-Higgs pairs $$h_i h_j=hh,hH,HH,AA$$

h
i

h
j

=
h
h
,
h
H
,
H
H
,
A
A

: $$e^+e^- \rightarrow h_i h_j Z$$

e
+

e
-

→

h
i

h
j

Z

and $$e^+e^- \rightarrow h_i h_j \nu {{\bar{\nu }}}$$

e
+

e
-

→

h
i

h
j

ν

ν

¯

. In both channels the various triple Higgs-boson couplings contribute substantially. We find regions with a strong enhancement of the production channel of two SM-like light Higgs bosons and/or with very large production cross sections involving one light and one heavy or two heavy 2HDM Higgs bosons, offering interesting prospects for the ILC or CLIC. The mechanisms leading to these enhanced production cross sections are analyzed in detail. We propose the use of cross section distributions with the invariant mass of the two final Higgs bosons where the contributions from intermediate resonant and non-resonant BSM Higgs bosons play a crucial role. We outline which process at which center-of-mass energy would be best suited to probe the corresponding triple Higgs-boson couplings.