bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revisiting $$\gamma ^*\rightarrow \gamma \pi ^0\eta $$ near the $$\phi (1020)$$ using analyticity and the left-cut structure
Authors: Moussallam B. 
Published: November 2021

AbstractAmplitudes of the form $$\gamma ^*(q^2)\rightarrow \gamma P_1P_2$$

γ
∗

(

q
2

)

→
γ

P
1

P
2

appear as sub-processes in the computation of the muon $$g-2$$

g
-
2

. We test a proposed theoretical modelling against very precise experimental measurements by the KLOE collaboration at $$q^2=m^2_\phi $$

q
2

=

m
ϕ
2

. Starting from an exact, parameter-free dispersive representation for the S-wave satisfying QCD asymptotic constraints and Low’s soft photon theorem we derive, in an effective theory spirit, a two-channel Omnès integral representation which involves two subtraction parameters. The discontinuities along the left-hand cuts which, for timelike virtualities, extend both on the real axis and into the complex plane are saturated by the contributions from the light vector mesons. In the case of $$P_1P_2=\pi \eta $$

P
1

P
2

=
π
η

, we show that a very good fit of the KLOE data can be achieved with two real parameters, using a T-matrix previously determined from $$\gamma \gamma $$

γ
γ

scattering data. This indicates a good compatibility between the two data sets and confirms the validity of the T-matrix. The resulting amplitude is also found to be compatible with the chiral soft pion theorem. Applications to the $$I=1$$

I
=
1

scalar form factors and to the $$a_0(980)$$

a
0

(
980
)

resonance complex pole are presented.
Entanglement minimization in hadronic scattering with pions
Authors: Beane Silas R. , Farrell Roland C. , Varma Mira 
Published: November 2021

Recent work [S. R. Beane, D. B. Kaplan, N. Klco and M. J. Savage, Phys. Rev. Lett. 122, 102001 (2019), arXiv:1812.03138.] conjectured that entanglement is minimized in low-energy hadronic scattering processes. It was shown that the minimization of the entanglement power (EP) of the low-energy baryon–baryon [Formula: see text]-matrix implies novel spin–flavor symmetries that are distinct from large-[Formula: see text] QCD predictions and are confirmed by high-precision lattice QCD simulations. Here, the conjecture of minimal entanglement is investigated for scattering processes involving pions and nucleons. The EP of the [Formula: see text]-matrix is constructed for the [Formula: see text] and [Formula: see text] systems, and the consequences of minimization of entanglement are discussed and compared with large-[Formula: see text] QCD expectations.
Gaps in Corporate Liability
Authors: Aparac Jelena 
Published: November 2021

Abstract
Fact-finding is a fundamental step in providing documentation that can be used in domestic and international proceedings. The United Nations establishes commissions of inquiry to investigate international law violations, often in contexts of armed conflict, under the mandate of the Human Rights Council or other more political organs of the UN. They vary in mandate, as well as in investigative and geographic scope. However, to this day, fact-finding mechanisms or inquiry commissions have only rarely conducted investigations into corporate crimes, even in cases where the UN has explicitly recognized the part played by economic actors in armed conflicts. Because corporations are not subjects of international law, they are presumed not to have any direct obligations under international law. Moreover, the mandates of fact-finding missions de facto exclude corporations from investigations because such mandates are always designed to investigate international law violations. By voluntarily dismissing any investigation of corporate crimes, the UN is significantly limiting prospects for corporate responsibility and impeding the process of transitional justice.
Projections of Snow Water Equivalent Using a Process-Based Energy Balance Snow Model in Southwestern British Columbia
Authors: Sobie Stephen R. , Murdock Trevor Q. 
Published: November 2021

Abstract
Information about snow water equivalent in southwestern British Columbia, Canada, is used for flood management, agriculture, fisheries, and water resource planning. This study evaluates whether a process-based, energy balance snow model supplied with high-resolution statistically downscaled temperature and precipitation data can effectively simulate snow water equivalent (SWE) in the mountainous terrain of this region. Daily values of SWE from 1951 to 2018 are simulated at 1-km resolution and evaluated using a reanalysis SWE product [Snow Data Assimilation System (SNODAS)], manual snow-survey measurements at 41 sites, and automated snow pillows at six locations in the study region. Simulated SWE matches observed interannual variability well (R2 > 0.8 for annual maximum SWE), but peak SWE biases of 20%–40% occur at some sites in the study domain, and higher biases occur where observed SWE is very low. Modeled SWE displays lower bias relative to SNODAS reanalysis at most manual survey locations. Future projections for the study area are produced using 12 downscaled climate model simulations and are used to illustrate the impacts of climate change on SWE at 1°, 2°, and 3°C of warming. Model results are used to quantify spring SWE changes at different elevations of the Whistler mountain ski resort and the sensitivity of annual peak SWE in the Metropolitan Vancouver municipal watersheds to moderate temperature increases. The results both illustrate the potential utility of a process-based snow model and identify areas where the input meteorological variables could be improved.

Significance Statement
Using high-resolution (1 km) climate data, we evaluate and apply a snow model in the mountainous terrain of coastal, southwestern British Columbia, Canada. Modeling snow water equivalent at high-resolution enables better representation of snow conditions that can vary widely over short distances and elevations. At 1°, 2°, and 3°C of warming, future snow water equivalent levels at sites nearer the coast are more vulnerable to temperature increases than sites slightly higher in elevation and farther inland. Future efforts to improve the climate data may yield better agreement between simulated and observed snow levels in certain locations.
Exploring performance paradox in public organizations: Analyzing the predictors of distortive behaviors in performance measurement
Authors: Choi Sungjoo , Park Soonae 
Published: November 2021

Scholars have argued that utilization of quantitative performance indicators by public organizations could generate unintended consequences that might outweigh the benefits of performance measurement. We examined the relationships between goal ambiguity and external control, and distortive practices in performance measurement in public organizations. The data from 47 agencies of the central and local governments in Korea were analyzed using fixed-effect ordered logistic regression methods. The results showed that goal ambiguity was positively and significantly associated with distortive practices in performance measurement. Goal ambiguity may incentivize public employees to misuse performance information to obtain rewards for higher performance ratings. Contrary to our expectation, reinforced external control was negatively and significantly related to distortive behaviors in performance measurement. Higher work autonomy was not significantly associated with manipulation of performance information. Employees with higher intrinsic motivation were less likely to distort performance measures, whereas the ones with higher extrinsic motivation were more likely to misuse performance information to achieve higher performance ratings. Points for practitioners To avoid the potential distortions in performance measurement, public managers should adopt a refined measurement model of performance customized to the unique characteristics of public services. Multiple sets of measures need to be developed and managed properly to respond to complex political environments which involve different key values and the stakeholders in the policy processes, and the nature of public service products and outcomes. Reinforced behavioral control in the process of measuring performance will also be necessary.
Effect of particle size of leather wastes on the processing, vulcanization, and physico-mechanical properties of natural rubber/leather wastes composites
Authors: Urrego Yepes William , Cardona Natalia , Velasquez Sandra M , Giraldo Vásquez Diego H , Posada Juan C 
Published: November 2021

In this work, the effect of particle size and the content of leather wastes on the processability, vulcanization, and mechanical properties of a natural rubber/leather wastes composites was studied. From a reduction process, leather waste was later sieved to classify particles smaller than 0.6 mm and particles between 0.84 and 2 mm, hereafter called fine and coarse residues, respectively. The morphology of the wastes was analyzed from scanning electron microscopy micrographs. Natural rubber/leather wastes composites with 20, 40, 60, 80, and 100 phr (parts per 100 parts of rubber) of treated leather wastes were obtained in a torque rheometer. Mixtures with coarse wastes exhibited a slightly higher torque than mixtures with the fine wastes; additionally, increasing the wastes content yields in an increased torque during the final stage of the process. The addition of leather wastes increased the vulcanization time and stiffness of the composites; additionally, materials with fine wastes showed lower vulcanization times compared to materials with coarse wastes. Composites with fine leather wastes exhibited higher density and tensile modulus than materials with coarse wastes; however, only the composites with 80 and 100 phr of wastes showed a statistically significant difference in hardness values. The specific energy consumption (SEC) was calculated from the results obtained with the torque rheometer; it was found that for all the formulations the SEC decreased as the phr of leather residues increased. It was found that it is possible to use leather wastes in natural rubber composites, to obtain adequate materials feasible for some applications.
Case report of sacituzumab govitecan-hziy-induced neutropenia in a patient with metastatic triple-negative breast cancer and a uridine diphosphate glucuronosyltransferase family 1 member A1 poor metabolizer genotype
Authors: Baek Grace , Jung Lindsey , Duong Arianne , Gralow Julie 
Published: November 2021

Introduction Sacituzumab govitecan-hziy, approved in 2020 for treatment of metastatic triple-negative breast cancer, provides a new option for a population with a historically poor prognosis with standard chemotherapy. Uridine diphosphate glucuronosyltransferase family 1 member A1 poor metabolizers are at increased risk for profound neutropenia. This case discusses clinical implications of the uridine diphosphate glucuronosyltransferase family 1 member A1*28/*28 genotype in patients receiving sacituzumab govitecan-hziy. Case report A 38-year-old otherwise healthy pre-menopausal female of South Asian descent was diagnosed with non-metastatic, hormone receptor-positive, and human epidermal growth factor receptor 2-negative breast cancer. This was treated with neoadjuvant chemotherapy and multiple lines of subsequent therapies. Upon finding bone metastasis, an additional six lines of therapy ensued. In total, 3.5 years post-diagnosis, sacituzumab govitecan-hziy was started for disease transformation to triple-negative status. Management and outcome Sacituzumab govitecan-hziy was initiated at the Food and Drug Administration-approved 10 mg/kg/dose on days 1 and 8 of a 21-day cycle. Grade 4 neutropenia occurred after one dose. Pharmacogenomics testing identified the patient as a uridine diphosphate glucuronosyltransferase family 1 member A1*28 homozygous expressor. Sacituzumab govitecan-hziy was dose-reduced, and granulocyte colony-stimulating factor was administered due to the severity of neutropenia. The patient continued on sacituzumab govitecan-hziy until disease progression. Discussion Sacituzumab govitecan-hziy's propensity to cause neutropenia is multifactorial. Although incidence of all-grade neutropenia from sacituzumab govitecan-hziy is elevated for uridine diphosphate glucuronosyltransferase family 1 member A1*28 homozygous expressors, this does not translate to increased risk for febrile neutropenia. Detailed guidance is lacking regarding empiric dose adjustments or prophylactic granulocyte colony-stimulating factor for these patients. 1 Currently, pre-sacituzumab govitecan-hziy pharmacogenomics testing to identify uridine diphosphate glucuronosyltransferase family 1 member A1 poor metabolizers is not recommended, and the cost-effectiveness of this approach is unclear.
Ocular adverse events following intravitreal brolucizumab for neovascular age-related macular degeneration at a single tertiary care center
Authors: Nguyen Huy V. , Li Angela S. , Silva Amila R. , Leng Theodore 
Published: November 2021

Purpose To determine the incidence of ocular adverse effects (AEs) following brolucizumab injection for neovascular age-related macular degeneration at a tertiary academic institution. Design Retrospective, single center cohort study. Participants All patients who received an intravitreal injection of brolucizumab 6 mg for neovascular age-related macular degeneration between October 7, 2019 and July 31, 2020. Methods Medical records of all patients who received brolucizumab 6 mg during the aforementioned time period were carefully reviewed and all ocular adverse effects after injection were charted. Main Outcome Measures Incidence of post-injection ocular AEs, including intraocular inflammation (IOI), and time to development of AEs after injection. Results A total of 77 patients received brolucizumab 6 mg for a total of 115 administrations during the study period. There were 4 AEs (3.5%), including three cases of IOI (2.6%), one central retinal artery occlusion, and one retinal detachment. Two men and two women were affected. Conclusion Ocular AEs, including those leading to severe vision loss, may develop after intravitreal brolucizumab 6 mg. A careful discussion of benefits and risks to brolucizumab should be conducted with all patients. Precis In this first case series of ocular adverse effects after brolucizumab 6 mg injection at a single tertiary care center, the incidence of ocular adverse effects was 3.5%, including a 2.6% incidence of intraocular inflammation.
A Study of Workspace Design Characteristics Exemplified by Nurses’ Satisfaction Within Three Intensive Care Units in a University Hospital
Authors: Obeidat Bushra , Younis Mohammad Bani , Al-Shlool Esra’a , Alzouby Ahmad 
Published: November 2021

Background: The critical conditions of intensive care patients require providing them with a higher acuity of care. Thus, it is essential to focus on critical care nurses and improve their work environment in a way that maximizes productivity, collaboration, satisfaction, and leads to improved patient care. Purpose This study aims to explore the role the workplace layout design play in determining nurses’ satisfaction in three intensive care units (ICUs) at a university hospital. Method: A prospective, cross-sectional, single-center, survey-based design was employed in this study. Data were obtained, via a standardized questionnaire, from 36 morning shift nurses. The nurses’ self-reported satisfaction scores in three different ICUs with differing overall layouts, nursing station locations, and workplace design were statistically compared. Results: The study found that ICU 1 (private rooms, single corridor, central nursing station, close to supported services) had higher nursing satisfaction levels than ICUs 2 and 3 (open wards with separate service zones), F (2,34) = 5.054, p = .012. However, overall satisfaction was higher with the ICU 2 primary workspace design, possibly due to the perceived acoustic privacy in this configuration, F (2,34)= 4.492, p = .019. The ability of the ICU layout design to enhance teamwork and minimize traffic in patients care areas was found to be an important predictor of nurses’ satisfaction. The primary workspace design capacity to minimize congestion and the presence of large numbers of providers in a confined workplace might account for variation in nurses’ satisfaction. Conclusion: Physical environment variables in the ICU design may contribute to staff workplace satisfaction scores and may help in guiding informed choices regarding the future ICU design.
Effects of Whole-Season Training and Match-Play on Hip Adductor and Abductor Muscle Strength in Soccer Players: A Pilot Study
Authors: Moreno-Pérez Víctor , Peñaranda Marcelo , Soler Aitor , López-Samanes Álvaro , Aagaard Per , Del Coso Juan 
Published: November 2021

Background: Previous investigations have associated weakness of hip muscles with a higher likelihood of developing hip groin injury. However, no previous investigation has examined the influence of soccer training and match-play during the season on maximal isometric hip adductor and abductor muscle strength. Hypothesis: Maximal hip adductor and abductor muscle strength would increase after the preseason, maintaining relatively constant levels across the soccer season. Design: Cross-sectional study. Level of Evidence: Level 3. Methods: A total of 26 semiprofessional male soccer players underwent measurements of maximal isometric hip adductor and abductor muscle strength at 3 time points of the soccer season: preseason, midseason, and end-season to investigate the longitudinal effect of soccer training and competition during a complete season on maximal isometric hip adductor and abductor muscle strength in the semiprofessional Spanish soccer player. Results: Compared with preseason, hip abductor muscle strength increased in the midseason (14.2% and 17.1%, for dominant and nondominant limb, respectively; P < 0.001) and in the end-season (13.1%; P = 0.005, and 14.1%; P < 0.005). In contrast, hip adductor muscle strength remained unchanged across the season in both limbs. As a result, the adductor/abductor strength ratio in the nondominant limb was reduced at midseason and end-season time points (−14.6% and −18.4%, respectively; P < 0.001) with a corresponding tendency in the dominant limb (−9.3% and −15.0%, respectively; P > 0.05). Conclusion: While maximal hip abductor muscle strength increased throughout the season, hip adductor muscle strength remained stable across the season. This produced a substantial deficit in hip adductor/abductor strength ratio at midseason and end-season. Clinical Relevance: The progressive imbalance in adductor/abductor strength across the soccer season may be an indicator of increased risk of groin injury and may reinforce the need for preventive rehabilitation activities focused on enhancing adductor muscle strength.
Epidural analgesia is associated with earlier gastrointestinal transit after radical cystectomy but does not reduce the incidence of postoperative ileus: A retrospective cohort study
Authors: Knoerlein Julian , Heinrich Sebastian , Kaufmann Kai , Schultze-Seemann Wolfgang , Baar Wolfgang , Kalbhenn Johannes 
Published: November 2021

Objective: To compare the effect of combined epidural thoracic analgesia and general anaesthesia (CEGA) in radical cystectomy (RC) with respect to the return of gastrointestinal passage, the incidence of paralytic postoperative ileus (POI) compared to general anaesthesia (GA) only. Patients and methods: We conducted a retrospective review using the electronic medical records of 236 patients who underwent RCs between July 2011 and September 2018 at the Medical Center – University of Freiburg. Results: A CEGA was administered to 202 patients, while 34 patients received only GA. The baseline characteristics of patients with and without CEGA showed no significant differences. CEGA will decrease the time required for return of gastrointestinal transit as measured by time to first defecation by about 13 hours. In the first 90 days after surgery, 82 (34.7%) patients had a POI. There was no significant difference between complications in the CEGA and GA groups. Conclusion: A CEGA accelerates the return of the gastrointestinal transit but does not reduce the incidence of postoperative ileus. Level of evidence: 2b
Momelotinib is a highly potent inhibitor of FLT3-mutant AML
Authors: Azhar Mohammad , Kincaid Zachary , Kesarwani Meenu , Ahmed Arhama , Wunderlich Mark , Latif Tahir , Starczynowski Daniel , Azam Mohammad 
Published: November 2021

Abstract
Despite the introduction of more selective FLT3 inhibitors to treat FLT3-mutated acute myeloid leukemia (AML), remissions are short lived, and patients show progressive disease after an initial response. Acquisition of resistance-conferring genetic mutations and growth factor signaling are 2 principal mechanisms that drive relapse. FLT3 inhibitors targeting both escape mechanisms could lead to a more profound and lasting clinical response. Here, we show that the JAK2 inhibitor momelotinib is an equipotent type 1 FLT3 inhibitor. Momelotinib showed potent inhibition of FLT3-internal tandem duplication in mouse and human primary cells and effectively suppressed its clinically relevant resistant variants within the activation loop at residues D835, D839, and Y842. Additionally, momelotinib efficiently suppressed the resistance mediated by growth factors and hematopoietic cytokine-activated JAK2 signaling. Consequently, concomitant inhibition of FLT3 and suppression of growth factor signaling by momelotinib treatment showed better efficacy in suppressing leukemia in a preclinical murine model of AML. Altogether, these data provide evidence that momelotinib is an effective type 1 dual JAK2/FLT3 inhibitor and may offer an alternative to gilteritinib. Its ability to impede the resistance conferred by growth factor signaling and activation loop mutants suggests that momelotinib treatment could provide a deeper and durable response and, thus, warrants its clinical evaluation.
MCT1 is a predictive marker for lenalidomide maintenance therapy in multiple myeloma
Authors: Stroh Jacob , Seckinger Anja , Heider Michael , Rudelius Martina , Eichner Ruth , Schick Markus , Slawska Jolanta , Emde-Rajaratnam Martina , Salwender Hans , Bertsch Uta , Goldschmidt Hartmut , Weisel Katja , Scheid Christof , Keller Ulrich , Hose Dirk , Bassermann Florian 
Published: November 2021

Abstract
Biomarkers that predict response to lenalidomide maintenance therapy in patients with multiple myeloma (MM) have remained elusive. We have shown that immunomodulatory drugs (IMiDs) exert anti-MM activity via destabilization of MCT1 and CD147. In this study, cell samples of 654 patients with MM who received lenalidomide (n = 455), thalidomide (n = 98), or bortezomib (n = 101) maintenance were assessed by gene expression profiling and RNA sequencing, followed by correlation of MCT1 and CD147 expression with data for progression-free survival (PFS) and overall survival (OS). Patients with high expression levels of MCT1 showed significantly reduced PFS (31.9 months vs 48.2 months in MCT1high vs MCT1low; P = .03) and OS (75.9 months vs not reached [NR] in MCT1high vs MCT1low; P = .001) in cases with lenalidomide maintenance, whereas MCT1 expression had no significant impact on PFS or OS in cases with bortezomib maintenance. We validated the predictive role of MCT1 for IMiD-based maintenance in an independent cohort of patients who received thalidomide (OS, 83.6 months vs NR in MCT1high vs MCT1low; P = .03). Functional validation showed that MCT1 overexpression in human MM cell lines significantly reduced the efficacy of lenalidomide, whereas no change was observed with bortezomib treatment, either in vitro or in a MM xenograft model. Our findings have established MCT1 expression as a predictive marker for response to lenalidomide-based maintenance in patients with MM.