bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polypharmacology of clinical sodium glucose co‐transport protein 2 inhibitors and relationship to suspected adverse drug reactions
Authors: Matharu Karan , Chana Kiran , Ferro Charles J. , Jones Alan M. 
Published: September 2021

AbstractSodium glucose co‐transporter 2 inhibitors (SGLT2i) are a promising second‐line treatment strategy for type 2 diabetes mellitus (T2DM) with a developing landscape of both beneficial cardio‐ and nephroprotective properties and emerging adverse drug reactions (ADRs) including diabetic ketoacidosis (DKA), genetic mycotic infections, and amputations among others. A national register study (MHRA Yellow Card, UK) was used to quantify the SGLT2i's suspected ADRs relative to theirRxrate (OpenPrescribing, UK). The polypharmacology profiles of SGLT2i were data‐mined (ChEMBL) for the first time. The ADR reports (n = 3629) and prescribing numbers (Rxn = 5,813,325) for each SGLT2i in the United Kingdom (from launch date to the beginning December 2019) were determined. Empagliflozin possesses the most selective SGLT2/SGLT1 inhibition profile at ~2500‐fold, ~10‐fold more selective than cangliflozin (~260‐fold). Canagliflozin was found to also inhibit CYP at clinically achievable concentrations. We find that for overall ADR rates, empagliflozin versus dapagliflozin and empagliflozin versus canagliflozin are statistically significant (χ2,p < .05), while dapagliflozin versus canagliflozin is not. In terms of overall ADRs, there is a greater relative rate for canagliflozin > dapagliflozin > empagliflozin. For fatalities, there is a greater relative rate for dapagliflozin > canagliflozin > empagliflozin. An organ classification that resulted in a statistically significant difference between SGLT2i was suspected infection/infestation ADRs between empagliflozin and dapagliflozin. Our findings at this stage of SGLT2i usage in the United Kingdom suggest that empagliflozin, the most selective SGLT2i, had the lowest suspected ADR incident rate (relative to prescribing) and in all reported classes of ADRs identified including infections, amputations, and DKA.
Exposure–response analysis of efficacy and safety for pexidartinib in patients with tenosynovial giant cell tumor
Authors: Yin Ophelia , Zahir Hamim , French Jonathan , Polhamus Daniel , Wang Xiaoning , van de Sande Michiel , Tap William D. , Gelderblom Hans , Wagner Andrew J. , Healey John H. , Greenberg Jonathan , Shuster Dale , Stacchiotti Silvia 
Published: September 2021

AbstractThis analysis was conducted to assess exposure–response relationships for efficacy and safety of pexidartinib in patients with tenosynovial giant cell tumor. Efficacy was assessed categorically by overall response rate (ORR) with Response Evaluation Criteria in Solid Tumors version 1.1 and longitudinally (changes in tumor size and volume). Safety included hepatic parameters (i.e., alanine aminotransferase [ALT], aspartate aminotransferase [AST], and total bilirubin). Average pexidartinib concentration (Cavg) was identified as the primary exposure parameter correlated with response. In categorical and longitudinal analyses, higher Cavg coincided with greater ORR and tumor size reduction, respectively, with smaller joint size having a greater impact. For safety, a significant relationship was observed between Cavg and incidence of ALT‐related and AST‐related adverse events (AEs). With increased exposure, an increase in efficacy was predicted with near maximum effect at 800 mg/day. Higher initial dose (1000 mg/day) during the first 2 weeks did not improve efficacy. Higher doses were associated with an increased risk of ALT‐related and AST‐related AEs. These results support the US Food and Drug Administration–approved dose (400 mg two times/day without initial loading dose).
A safe and effective anastomotic technique for robot‐assisted minimally invasive oesophagectomy: Reverse‐puncture anastomosis
Authors: Peng Hao , Liu Yi Yang , Aimudula Maimaitijiang , Wang Rong Chun , Chen Hao , Liu Xiaolong , Song Haizhu , Yi Jun 
Published: September 2021

AbstractBackgroundOesophagogastric anastomosis is mainly complicated by its tediousness. We hope to modify an oesophagogastric anastomotic technique that simplifies anastomosis.MethodsWe conducted a retrospective analysis of 57 cases executed using reverse‐puncture anastomotic (RPA) technique and 64 cases of manual purse anastomosis (MPA) technique for robot‐assisted minimally invasive oesophagectomy (RAMIE). Baseline characteristics and perioperative outcomes were analysed.ResultsThere were no significant differences between the 2 groups with regards to demographic data and clinical features. All patients had R0 resection. Relative to MPA, RPA group experienced significantly shorter operation times (232.5 ± 33.84 min vs. 262.3 ± 83.94 min, p = 0.038).RPA group patients had shorter anastomotic times relative to MPA group patients (10.5 ± 3.4 min vs. 18.3 ± 4.1 min, p = 0.014). No adverse events were observed.ConclusionsReverse‐puncture anastomosis is safe, feasible in RAMIE. This approach has the potential to efficiently shorten the anastomotic time and ensure safe operation.
Performing kayepa dordok living waters in Noongar boodjar, South‐Western Australia
Authors: Bracknell Clint , Horwitz Pierre , Ryan Trevor , Marshall Jonathan W. 
Published: September 2021

AbstractPerformance through language, song and dance provides alternative knowledges and ways of understanding, in this case, developing deeper relationships with living water. Drawing on Indigenous Noongar culture from south‐western Australia, this paper addresses the question: How can relationships between living underground, estuarine and riverine water bodies (kayepa dordok) be performed? Two new interlinked Noongar works in response to local riverscapes were developed for, and performed as part of, the 2021 Perth Festival. The first was to embody the return journey of the bullshark, from the salt water to the riverine fresh water; the second was to enact the presence of the unseen groundwater – which emerges as wetlands and estuaries strewn throughout the landscape – on its return to the sea. The method used to derive the song and dance, and the impact of the performance itself, are described. The experiment makes a case for multiple benefits associated with re‐establishing connections among culture and nature by drawing on Indigenous perspectives, through performance giving voice to a relationality between river systems and people.
Progress in Solid Polymer Electrolytes for Lithium‐Ion Batteries and Beyond
Authors: An Yong , Han Xue , Liu Yuyang , Azhar Alowasheeir , Na Jongbeom , Nanjundan Ashok Kumar , Wang Shengping , Yu Jingxian , Yamauchi Yusuke 
Published: September 2021

AbstractSolid‐state polymer electrolytes (SPEs) for high electrochemical performance lithium‐ion batteries have received considerable attention due to their unique characteristics; they are not prone to leakage, and they exhibit low flammability, excellent processability, good flexibility, high safety levels, and superior thermal stability. However, current SPEs are far from commercialization, mainly due to the low ionic conductivity, low Li+ transference number (tLi+), poor electrode/electrolyte interface contact, narrow electrochemical oxidation window, and poor long‐term stability of Li metal. Recent work on improving electrochemical performance and these aspects of SPEs are summarized systematically here with a particular focus on the underlying mechanisms, and the improvement strategies are also proposed. This review could lead to a deeper consideration of the issues and solutions affecting the application of SPEs and pave a new pathway to safe, high‐performance lithium‐ion batteries.
Using soft systems methodology to align community projects with sustainability development in higher education stakeholders' networks in a Brazilian university
Authors: Paucar‐Caceres Alberto , Cavalcanti‐Bandos Melissa Franchini , Quispe‐Prieto Silvia Cristina , Huerta‐Tantalean Lucero Nicole , Werner‐Masters Katarzyna 
Published: September 2021

AbstractThe purpose of this paper is to report on the use of the soft systems methodology (SSM) to enhance the role of the higher education institution (HEI) stakeholder's action networks in achieving the sustainable development goals (SDGs). We review the literature on sustainable development in HEIs, in particular the role of stakeholder networks for the implementation of SDGs in HEI. We outline some of the features of SSM as an approach to help make sense of this complexity. CATWOE analysis, a conceptual SSM tool, is applied to a stakeholder's network hosted by a Brazilian university with the purpose of achieving the SDGs as part of the community projects (HEI external engagement). Findings of the systemic application suggest that the use of some elements of SSM helps clarify and make sense of the role of the stakeholders and assists in formalising action networks to achieve SDGs.
Tailoring Breadfruit (Artocarpus altilis) Starch: Cross‐Linking Starch from This Non‐Conventional Source towards Improved Technologically Relevant Properties and Enabled Food Applications
Authors: Amorim Thaís Souza , Andrade Ivo Henrique Pinto , Otoni Caio Gomide , Camilloto Geany Peruch , Cruz Renato Souza 
Published: September 2021

AbstractThis contribution adds to the research on starch isolation from non‐conventional sources using green protocols, on which starch nanoparticles from breadfruit (Artocarpus altilis (Parkinson) Fosber), a traditionally underexploited, though starch‐rich species have previously reported. Here, it is demonstrated how cross‐linking can be used to overcome several technical limitations of native breadfruit starch that may hamper its use in food. Specifically, breadfruit starch is cross‐linked using a combination of sodium tripolyphosphate and sodium trimetaphosphate, which decreases the apparent amylose content while increases those of phosphorus and ash. Upon cross‐linking, starch density and oil uptake remain unchanged, water uptake is increased, and paste clarity is decreased by ca. 75%. Cross‐linking rendered breadfruit starch less prompt to retrogradation after five freeze‐thaw cycles. Native breadfruit starch swells less at 70 °C (2.68 g/g) than its cross‐linked counterpart (5.5 g/g), but the opposite behavior is observed at 90 °C (9.83 and 4.2 g/g, respectively). The greater resistance against syneresis and the lower swelling at higher temperatures drive cross‐linked breadfruit starch towards food products and processes that involve thermal treatment. Noteworthy, these benefits are achieved at a low degree of cross‐linking, which maintains phosphorus contents within the permitted levels.
Non‐cardiogenic pulmonary oedema and multisystemic haemorrhage secondary to an accidental intravenous injection of melarsomine in a dog
Authors: Wolf Johanna , Law Jerry M. , Lynch Alex 
Published: September 2021

AbstractAn 8‐month‐old female entire Labradoodle was referred for further management of severe non‐cardiogenic pulmonary oedema after an accidental intravenous injection of the arsenical compound melarsomine. On arrival, the dog was non‐ambulatory, obtunded and in severe respiratory distress. Due to profound hypoxaemia despite oxygen supplementation, the dog was intubated and mechanically ventilated. While anaesthetised, the dog experienced three episodes of cardiac arrest with return of spontaneous circulation after cardiopulmonary resuscitation. However, due to continued severe hypoxaemia and haemodynamic instability, euthanasia was elected by the owners. On necropsy, marked pulmonary oedema and haemorrhage into multiple organs, including the endocardium and brain, were identified. Although no other reports describe the consequences of intravenous melarsomine in dogs, the postmortem findings are very similar to intravenous arsenic toxicity in humans. Furthermore, this case report highlights the importance of accurate drug labelling.
EduCOR: An Educational and Career-Oriented Recommendation Ontology
Authors: Ilkou Eleni , Abu-Rasheed Hasan , Tavakoli Mohammadreza , Hakimov Sherzod , Kismihók Gábor , Auer Sören , Nejdl Wolfgang 
Published: September 2021

AbstractWith the increased dependence on online learning platforms and educational resource repositories, a unified representation of digital learning resources becomes essential to support a dynamic and multi-source learning experience. We introduce the EduCOR ontology, an educational, career-oriented ontology that provides a foundation for representing online learning resources for personalised learning systems. The ontology is designed to enable learning material repositories to offer learning path recommendations, which correspond to the user’s learning goals and preferences, academic and psychological parameters, and labour-market skills. We present the multiple patterns that compose the EduCOR ontology, highlighting its cross-domain applicability and integrability with other ontologies. A demonstration of the proposed ontology on the real-life learning platform eDoer is discussed as a use case. We evaluate the EduCOR ontology using both gold standard and task-based approaches. The comparison of EduCOR to three gold schemata, and its application in two use-cases, shows its coverage and adaptability to multiple OER repositories, which allows generating user-centric and labour-market oriented recommendations.Resource: https://tibonto.github.io/educor/.
Civil Society and Latent Mobilisation Under Authoritarian Neoliberal Governance
Authors: Yabancı Bilge 
Published: September 2021

AbstractThis chapter reflects on the impact of Turkey’s authoritarian neoliberal governance on the transformation of civil society with a particular focus on latent counter-mobilisation. The first section focuses on howAdalet ve Kalkınma Partisi(Justice and Development Party, AKP) has transformed civic space through a selective approach that switches between repression and facilitation. The AKP represses autonomous and dissident organisations and activists through judicial harassment and new regulations while facilitating the growth of a government-oriented civil society sector (GONGOs). The GONGOs fulfil two aims: softening the immediate effects of the state’s withdrawal from social provision and generating bottom-up consent for authoritarian neoliberal governance. The second section analyses resistance against the AKP’s authoritarian neoliberalism by focusing on the case of a unique social movement,Müslüman Sol hareket(Muslim Left movement), which fuses class politics with Islamic social justice. Based on insights from original fieldwork and interviews with activists conducted in 2018–2019 in Turkey, the discussion demonstrates that the syncretic amalgamation of socialism with Islamic justice has emerged at the unexpected intersections of ideologies and everyday experiences and challenges simultaneously the AKP’s neoliberal exploitation, instrumentalisation and politicisation of religion, and authoritarian governance.
Automated EW corrections with isolated photons: t$$ \overline{t} $$γ, t$$ \overline{t} $$γγ and tγj as case studies
Authors: Pagani Davide , Shao Hua-Sheng , Tsinikos Ioannis , Zaro Marco 
Published: September 2021

Abstract
In this work we compute for the first time the so-called Complete-NLO predictions for top-quark pair hadroproduction in association with at least one isolated photon (t$$ \overline{t} $$

t
¯

γ). We also compute NLO QCD+EW predictions for the similar case with at least two isolated photons (t$$ \overline{t} $$

t
¯

γγ) and for single-top hadroproduction in association with at least one isolated photon. In addition, we complement our results with NLO QCD+EW predictions of the hadronic and leptonic decays of top-quark including an isolated photon. All these results have been obtained in a completely automated approach, by extending the capabilities of the MadGraph5_aMC@NLO framework and enabling the Complete-NLO predictions for processes with isolated photons in the final state. We discuss the technical details of the implementation, which involves a mixed EW renormalisation scheme for such processes.
Resonance refraction and neutrino oscillations
Authors: Smirnov Alexei Y. , Valera Victor B. 
Published: September 2021

Abstract
The refraction index and matter potential depend on neutrino energy and this dependence has a resonance character associated to the production of the mediator in the s−channel. For light mediators and light particles of medium (background) the resonance can be realized at energies accessible to laboratory experiments. We study properties of the energy dependence of the potential for different C-asymmetries of background. Interplay of the background potential and the vacuum term leads to (i) bump in the oscillation probability in the resonance region, (ii) dip related to the MSW resonance in the background, (iii) substantial deviation of the effective ∆m2 above the resonance from the low energy value, etc. We considered generation of mixing in the background. Interactions with background shifts the energy of usual MSW resonance and produces new MSW resonances. Searches of the background effects allow us to put bounds on new interactions of neutrinos and properties of the background. We show that explanation of the MiniBooNE excess, as the bump due to resonance refraction, is excluded.
Presymplectic AKSZ formulation of Einstein gravity
Authors: Grigoriev Maxim , Kotov Alexei 
Published: September 2021

Abstract
Any local gauge theory can be represented as an AKSZ sigma model (upon parameterization if necessary). However, for non-topological models in dimension higher than 1 the target space is necessarily infinite-dimensional. The interesting alternative known for some time is to allow for degenerate presymplectic structure in the target space. This leads to a very concise AKSZ-like representation for frame-like Lagrangians of gauge systems. In this work we concentrate on Einstein gravity and show that not only the Lagrangian but also the full-scale Batalin-Vilkovisky (BV) formulation is naturally encoded in the presymplectic AKSZ formulation, giving an elegant supergeometrical construction of BV for Cartan-Weyl action. The same applies to the main structures of the respective Hamiltonian BFV formulation.
The two-sphere partition function in two-dimensional quantum gravity at fixed area
Authors: Mühlmann Beatrix 
Published: September 2021

Abstract
We discuss two-dimensional quantum gravity coupled to conformal matter and fixed area in a semiclassical large and negative matter central charge limit. In this setup the gravity theory — otherwise highly fluctuating — admits a round two-sphere saddle. We discuss the two-sphere partition function up to two-loop order from the path integral perspective. This amounts to studying Feynman diagrams incorporating the fixed area constraint on the round two-sphere. In particular we find that all ultraviolet divergences cancel to this order. We compare our results with the two-sphere partition function obtained from the DOZZ formula.
Primary admission and secondary transfer of trauma patients to Dutch level I and level II trauma centers: predictors and outcomes
Authors: van den Driessche Claire R. L. , Sewalt Charlie A. , van Ditshuizen Jan C. , Stocker Lisa , Verhofstad Michiel H. J. , Van Lieshout Esther M. M. , Hartog Dennis Den ,   Dutch Trauma Registry Southwest, van Buijtenen J. M. , den Hoed P. T. , Jakma T. S. C. , de Klerk G. , Roukema G. R. 
Published: September 2021

Abstract
Purpose
The importance and impact of determining which trauma patients need to be transferred between hospitals, especially considering prehospital triage systems, is evident. The objective of this study was to investigate the association between mortality and primary admission and secondary transfer of patients to level I and II trauma centers, and to identify predictors of primary and secondary admission to a designated level I trauma center.

Methods
Data from the Dutch Trauma Registry South West (DTR SW) was obtained. Patients ≥ 18 years who were admitted to a level I or level II trauma center were included. Patients with isolated burn injuries were excluded. In-hospital mortality was compared between patients that were primarily admitted to a level I trauma center, patients that were transferred to a level I trauma center, and patients that were primarily admitted to level II trauma centers. Logistic regression models were used to adjust for potential confounders. A subgroup analysis was done including major trauma (MT) patients (ISS > 15). Predictors determining whether patients were primarily admitted to level I or level II trauma centers or transferred to a level I trauma center were identified using logistic regression models.

Results
A total of 17,035 patients were included. Patients admitted primarily to a level I center, did not differ significantly in mortality from patients admitted primarily to level II trauma centers (Odds Ratio (OR): 0.73; 95% confidence interval (CI) 0.51–1.06) and patients transferred to level I centers (OR: 0.99; 95%CI 0.57–1.71). Subgroup analyses confirmed these findings for MT patients. Adjusted logistic regression analyses showed that age (OR: 0.96; 95%CI 0.94–0.97), GCS (OR: 0.81; 95%CI 0.77–0.86), AIS head (OR: 2.30; 95%CI 2.07–2.55), AIS neck (OR: 1.74; 95%CI 1.27–2.45) and AIS spine (OR: 3.22; 95%CI 2.87–3.61) are associated with increased odds of transfers to a level I trauma center.

Conclusions
This retrospective study showed no differences in in-hospital mortality between general trauma patients admitted primarily and secondarily to level I trauma centers. The most prominent predictors regarding transfer of trauma patients were age and neurotrauma. These findings could have practical implications regarding the triage protocols currently used.
Osteoporotic mid-thoracic vertebral body fractures: what are the differences compared to fractures of the lumbar spine?—a systematic review
Authors: Spiegl Ulrich Josef , Scheyerer Max Joseph , Osterhoff Georg , Grüninger Sebastian , Schnake Klaus John 
Published: September 2021

Abstract
Purpose
The aim of this systematically review is to detect differences between fractures located at the mid-thoracic spine compared to fractures of the thoracolumbar junction (TLJ) and the lumbar spine in osteoporotic vertebral body fractures.

Methods
This review is based on articles retrieved by a systematic search in the PubMed and Web of Science database for publications regarding osteoporotic fractures of the thoracolumbar spine with respect to the fracture location. Differences in prevalence, cause of fracture, fracture healing, and outcomes between the mid-thoracic spine and the TLJ and the lumbar spine were considered.

Results
Altogether, 238 articles could be retrieved from the literature search. A total of 222 articles were excluded. Thus, 16 remaining original articles were included in this systematic review comprising the topics prevalence, bone mineral density and regional blood flow, biomechanics, subsequent fractures, and outcome, respectively. The overall level of evidence of the vast majority of studies was moderate to low.

Conclusion
Several differences between osteoporotic fractures of the mid-thoracic spine compared to the TLJ and the lumbar spine could be identified. Thereby, osteoporotic mid-thoracic fractures seem to be particularly more related to frailty without a history of traumatic injury compared to osteoporotic fractures of the TLJ and the lumbar spine. Additionally, the presence of severe mid-thoracic fractures predicts subsequent fractures of the hip. In contrast, subsequent fractures of the spine are less likely.