bluuebunny/crossref_metadata_2025_split huggingface dataset:
Secondary care interface: optimising communication between teams within secondary care to improve the rehabilitation journey for older people
Authors: Testrow Sean , McGovern Ryan , Tully Vicki 
Published: February 2021

Effective communication between members of the multidisciplinary team is imperative for patient safety. Within the Medicine for the Elderly wards at Royal Victoria Hospital (RVH) in Dundee, we identified an inefficient process of information-sharing between the orthopaedics outpatient department (OPD) at the main teaching hospital and our hospital’s rehabilitation teams, and sought to improve this by introducing several changes to the work system. Our aim was for all patients who attended the OPD clinic to have a plan communicated to the RVH team within 24 hours.Before our intervention, clinic letters containing important instructions for ongoing rehabilitation were dictated by the OPD team, transcribed and uploaded to an electronic system before the RVH team could access them. We analysed clinic attendances over a 4-week period and found that it took 15 days on average for letters to be shared with the RVH teams. We worked with both teams to develop a clinical communication tool and new processes, aiming to expedite the sharing of key information. Patients attended the OPD with this form, the clinician completed it at the time of their appointment and the form returned with the patient to RVH on the same day.We completed multiple Plan–Do–Study–Act cycles; before our project was curtailed by the COVID-19 pandemic. During our study period, seven patients attended the OPD with a form, with all seven returning to RVH with a completed treatment plan documented by the OPD clinician. This allowed rehabilitation teams to have access to clinic instructions generated by orthopaedic surgeons almost immediately after a patient attended the clinic, essentially eliminating the delay in information-sharing.The introduction of a simple communication tool and processes to ensure reliable transfer of information can expedite information-sharing between secondary care teams and can potentially reduce delays in rehabilitation.
Palliative Care Home Support Packages (PEACH): a carer cross-sectional survey
Authors: Chow Josephine Sau Fan , Barclay Greg , Harlum Janeane , Swierczynski Jolanta , Jobburn Kim , Agar Meera 
Published: February 2021

BackgroundIn December 2013, a partnership between five local health districts and a non-governmental organisation implemented the Palliative Care Home Support Packages (PEACH) Program. The PEACH Program aims to support palliative care clients in their last days of life at their own home. This study sought to evaluate the quality of care delivered by the service from the perspective of clients’ primary carers.MethodsA letter was sent to carers of clients 6–10 weeks after the client’s death, inviting them to participate in an anonymous survey. The survey measured the level of satisfaction on various aspects of the service using FAMCARE and Likert scales, and invited for comments about the care received and suggestions for improvement.ResultsOut of 17 aspects of care provided by the PEACH Program, 13 were scored with ‘exceptional’ or ‘acceptable performance’. The highest satisfaction was observed in meeting clients’ physical needs and providing pain relief. The most dissatisfaction was observed in addressing spiritual matters, family conferences and information about treatment side effects. Ninety-five per cent of responses were either ‘satisfied’ or ‘very satisfied’ with the overall care provided at home during the last week of the client’s life.ConclusionThe results of this research provide further evidence to the field of what constitutes a good home death and the support mechanisms required to enable this. The results also have strong implications on how local services provided by the PEACH Program are delivered in the future.
Identification and operationalisation of indicators to monitor successful uptake of advance care planning policies: a modified Delphi study
Authors: Fassbender Konrad , Biondo Patricia , Holroyd-Leduc Jayna , Potapov Alexei , Wityk Martin Tracy Lynn , Wasylenko Eric , Hagen Neil Angus , Simon Jessica 
Published: February 2021

BackgroundIn 2014, the province of Alberta, Canada implemented a province-wide policy and procedures for advance care planning (ACP) and goals of care designation (GCD) across its complex, integrated public healthcare system. This study was conducted to identify and operationalise performance indicators for ACP/GCD to monitor policy implementation success and sustainment of ACP/GCD practice change.MethodsA systematic review and environmental scan was conducted to identify potential indicators of ACP/GCD uptake (n=132). A purposive sample of ACP/GCD stakeholders was invited to participate in a modified Delphi study to evaluate, reduce and refine these indicators through a combination of face-to-face meetings and online surveys.ResultsAn evidence-informed Donabedian by Institute of Medicine (IOM) framework was adopted as an organising matrix for the indicators in an initial face-to-face meeting. Three online survey rounds reduced and refined the 132 indicators to 18. A final face-to-face meeting operationalised the indicators into a measurable format. Nine indicators, covering 11 of the 18 Donabedian×IOM domains, were operationalised.ConclusionsNine ACP/GCD evidence-informed indicators mapping to 11 of 18 Donabedian×IOM domains were endorsed, and have been operationalised into an online ACP/GCD dashboard. The indicators provide a characterisation of ACP/GCD uptake that could be generalised to other healthcare settings, measuring aspects related to ACP/GCD documentation, patient satisfaction and agreement between medical orders and care received. The final nine indicators reflect the stakeholders’ expressed intent to strike a balance between comprehensiveness and feasibility within a large provincial healthcare system.
Long-distance movements and associated diving behaviour of ringed seals (Pusa hispida) in the eastern Canadian Arctic
Authors: Ogloff Wesley R. , Ferguson Steven H. , Fisk Aaron T. , Marcoux Marianne , Hussey Nigel E. , Jaworenko Andrew , Yurkowski David J. 
Published: February 2021

Animal distribution and movement facilitate energy and nutrient transfer within and between regions, thus influencing ecosystem structure and function. Ringed seals (Pusa hispida (Schreber, 1775)) have been observed making sustained, extensive migrations (>1000 km) in the western Canadian Arctic, but observations of their movements from the eastern Canadian Arctic are limited. We equipped 12 ringed seals with satellite telemetry tags in Resolute Bay (n = 7; 2012, 2013) and Tremblay Sound (n = 5; 2017, 2018), Nunavut, to monitor their movements, behavioural states, and diving behaviour from late summer until their spring moult. Six tags transmitted into winter and recorded long-distance movements to southeastern Baffin Island, with three seals travelling through central Baffin Bay (3608 ± 315 km; maximum 4226 km), whereas three travelled along the Baffin Island coastline (3674 ± 655 km; maximum 4872 km). Seals that travelled through central Baffin Bay made shallower dives (25.4 ± 1.1 m) than those that travelled near the coast (100.0 ± 4.1 m). Results provide new information on the variability, scales, and pathways of movement and diving behaviour of eastern Canadian Arctic ringed seals. This new knowledge can be used to inform spatial conservation and management priorities of this ecologically and culturally important species.
Effect on forage yield and nutrient uptake of long-term surface application of manure at various rates and times in the growing season to timothy grown on two contrasting soils
Authors: Rodd A.V. , Wells J. , Fillmore S.A.E. , Smith E.L. , Gordon R. , Madani A. , MacLeod J. , Nyiraneza J. , Fuller K. , Grimmett M.G. , Mills A. 
Published: February 2021

Although much of the manure in Canada is surface-applied to forages, little research exists evaluating time of year (Time) and rate (Rate) of application on forage yield and nutrient uptake. Field trials (10 yr) on two soils (sandy loam upland and silty clay loam dykeland) investigated this. Experimental arrangement was a factorial [Time (spring, summer, early, and late fall manure applications)] plus a control [spring-applied ammonium nitrate fertilizer (ANF)] in a Latinized split plot. ANF at 0, 25, 50, 100 and 200 kg N·ha−1; 0, 75, 150, and 300 as semi-solid beef (SSM) and 150 kg N·ha−1 as liquid dairy manure (LDM), constituted respective splits. The Time × Rate interaction, later in the trial on the upland soil, showed higher yields and nutrient uptakes with fall manure application. There was little interaction on the dykeland soil; summer application resulted in higher yields at times. For both soils, the optimal long-term application rate of SSM was approximately 150 kg N·ha−1 while that of ANF was approximately 100 kg N·ha−1. Inherent fertility of dykelands resulted in lesser responses to manure addition. Negligible and significant residual N occurred with fertilizer and manure, respectively. Nitrogen, phosphorus, potassium, calcium, magnesium, manganese, copper, zinc, and boron uptakes were due to amendment impact on yield. The recommended rate is 150 kg N·ha−1 of SSM or LDM applied in fall and summer to Maritime grasslands grown on upland and dykeland soils, respectively. Yield differences may not warrant producers adjusting timing of in-season manure application.
A comprehensive analysis of differential cross sections and analyzing powers in the proton–deuteron break-up channel at 135 MeV
Authors: Tavakoli-Zaniani H. , Eslami-Kalantari M. , Amir-Ahmadi H. R. , Bayat M. T. , Deltuva A. , Golak J. , Kalantar-Nayestanaki N. , Kistryn St. , Kozela A. , Mardanpour H. , Messchendorp J. G. , Mohammadi-Dadkan M. , Ramazani-Moghaddam-Arani A. , Ramazani-Sharifabadi R. , Skibiński R. , Stephan E. , Witała H. 
Published: February 2021

AbstractA selection of measured cross sections and vector analyzing powers, $$A_{x}$$

A
x

and $$A_{y}$$

A
y

, are presented for the $$\vec {p}{d}$$

p
→

d

break-up reaction. The data are taken with a polarized proton beam with a kinetic energy of 135 MeV using the Big Instrument for Nuclear-polarization Analysis (BINA) at KVI, the Netherlands. With this setup, $$A_{x}$$

A
x

is extracted for the first time for a large range of energies as well as polar and azimuthal angles of the two outgoing protons. For most of the configurations, the results at small and large relative azimuthal angles differ in behavior when comparing experimental data with the theoretical calculations. We also performed a more global comparison of our data with theoretical calculations. The cross-section results show huge values of $$\chi ^{2}$$

χ
2

/d.o.f.. The absolute values of $$\chi ^{2}$$

χ
2

/d.o.f. for the components of vector analyzing powers, $$A_{x}$$

A
x

and $$A_{y}$$

A
y

, are smaller than the ones for the cross section, partly due to larger uncertainties for these observables. However, also for these observables no satisfactory agreement is found for all angular combinations. This implies that the present models of a three-nucleon force are not able to provide a satisfactory description of experimental data.
Effect of Lower Surface Roughness on Nonlinear Hydraulic Properties of Fractures
Authors: Li Jinglong , Li Xianghui , Zhang Bo , Sui Bin , Wang Pengcheng , Zhang Mi 
Published: February 2021

This study investigates the effect of fracture lower surface roughness on the nonlinear flow behaviors of fluids through fractures when the aperture fields are fixed. The flow is modeled with hydraulic pressure

drop
=

10

−
4

~

10

5

Pa
/
m

by solving the Navier-Stokes equations based on rough fracture models with lower surface roughness varying from

JRC
=
1

to

JRC
=
19

. Here, JRC represents joint roughness coefficient. The results show that the proposed numerical method is valid by comparisons between numerically calculated results with theoretical values of three parallel-plate models. With the increment of hydraulic pressure drop from 10-4 to 105 Pa/m spanning ten orders of magnitude, the flow rate increases with an increasing rate. The nonlinear relationships between flow rate and hydraulic pressure drop follow Forchheimer’s law. With increasing the JRC of lower surfaces from 1 to 19, the linear Forchheimer coefficient decreases, whereas the nonlinear Forchheimer coefficient increases, both following exponential functions. However, the nonlinear Forchheimer coefficient is approximately three orders of magnitude larger than the linear Forchheimer coefficient. With the increase in Reynolds number, the normalized transmissivity changes from constant values to decreasing values, indicating that fluid flow transits from linear flow regimes to nonlinear flow regimes. The critical Reynolds number that quantifies the onset of nonlinear fluid flow ranges from 21.79 to 185.19.
СИНТЕЗ І ДОСЛІДЖЕННЯ ПРОТИЗАПАЛЬНОЇ АКТИВНОСТІ ДЕЯКИХ ТІАЗОЛО[4,3-b]ХІНАЗОЛІНІВ
Authors: Chulovska Z. I. , Drapak I. V. , Chaban I. G. , Nektegaev I. O. 
Published: February 2021

Мета роботи. Здійснити синтез деяких тіазоло[4,3-b]хіназолінів та провести дослідження протизапальної активності новосинтезованих сполук.
Матеріали і методи. Органічний синтез, 1Н ЯМР-спектроскопія, елементний аналіз, фармакологічний скринінг.
Результати й обговорення. З метою отримання нових біологічно активних речовин, нами запропоновано спосіб формування важкодоступної тіазоло[4,3-b]хіназолінової системи, який базується на внутрішньомолекулярній циклізації 2-(2-оксо-тіазолідин-4-іліденеаміно)-бензоатної кислоти. На основі реакцій Кньовенагеля та азосполучення проведено функціоналізацію положення С3 базового 3Н-тіазоло[4,3-b]хіназолін-1,9-діону з утворенням відповідних 3-ариліден та 3-арилгідразопохідних. Будова отриманих сполук та інтерпретація проведених хімічних досліджень підтверджена даними елементного аналізу та ЯМР 1Н-спектроскопією. Проведено фармакологічний скринінг протизапальної активності сполук. Отримані результати дозволили виділити 2 сполуки з вираженим протизапальним ефектом, які за показниками активності наближаються до або перевищують препарат порівняння Ібупрофен, що дає підстави вважати зазначену конденсовану систему перспективним молекулярним каркасом для дизайну потенційних протизапальних агентів
Висновки. Встановлено, шо при використанні м'яких дегідратуючих засобів 2-(2-оксотіазолідин-4-іліденеаміно)-бензоатної кислоти зазнає циклізації з утворенням базового 3Н-тіазоло[4,3-b]хіназолін-1,9-діону. Отриманий скафолд апробовано у реакціях Кньовенагеля та азосполучення з отриманням відповідних С3 заміщених тіазоло[4,3-b]хіназолінів. У процесі вивчення протизапальної активності виділено 2 високоактивні сполуки.
Endogenous bacterial community structure of Pinus massoniana with differing resistance to pine wilt disease
Authors: Lu Wei , Zhao Xiao-Jia , Tan Jia-Jin 
Published: February 2021

Summary
Pine wilt disease (PWD) is a devastating pine disease caused by Bursaphelenchus xylophilus and its main host in China is Pinus massoniana. The relationship between endophytic bacteria and disease resistance in P. massoniana remains unclear. In this paper, the leaves, roots, stems and treetops of different disease-resistant P. massoniana were studied as the research objective and Illumina MiSeq sequencing was used to analyse whether there were significant differences in the composition and diversity of endophytic bacterial communities between different disease-resistant P. massoniana. The results showed that at the genus level there were no obvious differences in the composition of the endophytic bacterial community of different disease-resistant P. massoniana in the leaves, but there were obvious differences in the roots, stems and treetops. The richness and diversity of endophytic bacteria in P. massoniana had no significant impact on its disease resistance, whilst the structure of endophytic bacterial community in stems and treetops may be related to its disease resistance.
Aporia in Umayyad Art or the Degree Zero of the Visual Forms’ Meaning in Early Islam
Authors: Gonzalez Valerie 
Published: February 2021

Abstract
This article re-examines the established findings about Umayyad art as a transitional production essentially anchored in the Western and Eastern Late Antique traditions that have inspired it. It argues instead that the Umayyads brought about an aesthetic revolution laying out the foundations of what has become known as “Islamic ornament,” a predominantly aniconic art form. An epistemological shift from art history to critical inquiry allows us to show that, beyond the adaptive borrowing of pre-existing forms, the Umayyads redefined the art’s condition of meaning based on an unprecedented attitude to images and visual discourse informed by Islamic ontotheology and logocentric metaphysics.
The Flow Field, Particle Distribution, and Determination of the Optimal Sampling Area around Aircraft
Authors: Wang Baoqing , Tang Zhenzhen , Li Yinuo , Cai Ningning 
Published: February 2021

AbstractParticle trajectories around an aircraft will change during a flight; therefore, analyzing particle distribution around the aircraft is necessary to accurately sample aerosols. Both computational fluid dynamics (CFD) simulations and wind tunnel experiments are employed to optimize the sampling zones around an aircraft. The wind tunnel model is the Harbin Y-12, similar to the Twin Otter and King Air. The aircraft head is taken as the coordinate original point. The coordinate X is parallel to the wings, the coordinate Y is parallel to the fuselage, and the coordinate Z is perpendicular to the fuselage. The results show that the closer the distance to the central line for the X direction is, the greater the velocity error is. A suitable position for sampling is under the fuselage because of low turbulence, convenient connection pipelines, and safety considerations. The shadow and enhancement zone area thicknesses gradually increase with increasing particle size. The shadow zone thickness under the fuselage is approximately 20, 70, 110, and 350 mm for particle sizes of 1, 10, 20, and 50 μm, respectively. The greater the distance from the aircraft head for the Y direction is, the smaller the velocity error is. The attack angle has no obvious effect on the flow speed at different positions. The CFD simulation results are in basic agreement with the wind tunnel experiment results. The optimal sampling zone is approximately 2300–6500 mm for the Y direction for the aircraft head, 250–500 mm for the X direction for the aircraft head, and 490–600 mm for the Z direction under the fuselage of aircraft.
Association between alcohol intake and the risk of systemic lupus erythematosus: A systematic review and meta-analysis
Authors: Wang Jinghua , Liu Jinxiang , Pan Lu , Guo Lishuang , Liu Congcong , Yang Sirui 
Published: February 2021

Objectives Previous studies have reported inconsistent results on the relationship between alcohol intake and the risk of systemic lupus erythematosus (SLE). Therefore, we conducted a systematic review and meta-analysis to illustrate the potential role of alcohol intake on the progression of SLE. Methods An electronic search of the PubMed, EmBase, and the Cochrane library databases was conducted from their inception up to March 2020. Observational studies that investigated the role of alcohol intake on the risk of SLE were eligible for inclusion in this study. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated as an effect estimate using the random-effects model. Results Seven case-control studies (n = 3, 251) and three cohort studies (n = 322, 479) were selected for the final meta-analysis. Mild (OR: 0.85; 95% CI: 0.53–1.38; p = 0.515) or heavy (OR: 0.63; 95% CI: 0.37–1.09; p = 0.102) alcohol intake were not associated with the risk of SLE, while moderate alcohol intake could protect against the risk of SLE (OR: 0.71; 95% CI: 0.55–0.93; p = 0.012). Sensitivity analysis suggested that heavy alcohol intake was associated with a reduced risk of SLE (OR: 0.47; 95% CI: 0.32–0.67; p < 0.001). Conclusions This study found that moderate alcohol intake could protect against the risk of SLE, while mild or heavy alcohol intake did not significantly affect the risk of SLE.
The fifty most cited publications in shoulder arthroplasty research
Authors: Cohn Matthew R , Mehta Nabil , Kunze Kyle N , Browning Robert B , Verma Nikhil N , Garrigues Grant E , Nicholson Gregory P 
Published: February 2021

Introduction Frequency of citation provides one quantitative metric of the impact that an article has on a given field. The purpose of this study was to evaluate characteristics of the 50 most cited publications on shoulder arthroplasty. Methods The Web of Science database was used to determine the 50 most frequently cited shoulder arthroplasty articles. Articles were evaluated for several factors including type of arthroplasty, citation frequency and rate, source journal, country of origin, study type, and level of evidence. Results The most common countries of origin were the United States (60%) followed by France (24%) and Switzerland (6%). A total of 27 (54%) articles included anatomic total shoulder arthroplasty (TSA), 18 (36%) included reverse total shoulder arthroplasty (RTSA), and 15 (30%) included hemiarthroplasty. Articles including RTSA had the greatest number of citations compared to those on TSA ( p = 0.037) and hemiarthroplasty ( p = 0.035). Citations per year were also greatest with RTSA compared to TSA and hemiarthroplasty ( p ≤ 0.001). Discussion This citation analysis includes many of the landmark studies that shaped, and continue to impact, the field of shoulder arthroplasty. This list provides a group of influential articles that provide a foundation for future research in shoulder arthroplasty.
Factor XIII cross-links fibrin(ogen) independent of fibrin polymerization in experimental acute liver injury
Authors: Poole Lauren G. , Kopec Anna K. , Groeneveld Dafna J. , Pant Asmita , Baker Kevin S. , Cline-Fedewa Holly M. , Flick Matthew J. , Luyendyk James P. 
Published: February 2021

Abstract
Intravascular fibrin clot formation follows a well-ordered series of reactions catalyzed by thrombin cleavage of fibrinogen leading to fibrin polymerization and cross-linking by factor XIIIa (FXIIIa). Extravascular fibrin(ogen) deposits are observed in injured tissues; however, the mechanisms regulating fibrin(ogen) polymerization and cross-linking in this setting are unclear. The objective of this study was to determine the mechanisms of fibrin polymerization and cross-linking in acute liver injury induced by acetaminophen (APAP) overdose. Hepatic fibrin(ogen) deposition and cross-linking were measured following APAP overdose in wild-type mice, mice lacking the catalytic subunit of FXIII (FXIII−/−), and in FibAEK mice, which express mutant fibrinogen insensitive to thrombin-mediated fibrin polymer formation. Hepatic fibrin(ogen) deposition was similar in APAP-challenged wild-type and FXIII−/− mice, yet cross-linking of hepatic fibrin(ogen) was dramatically reduced (&gt;90%) by FXIII deficiency. Surprisingly, hepatic fibrin(ogen) deposition and cross-linking were only modestly reduced in APAP-challenged FibAEK mice, suggesting that in the APAP-injured liver fibrin polymerization is not strictly required for the extravascular deposition of cross-linked fibrin(ogen). We hypothesized that the oxidative environment in the injured liver, containing high levels of reactive mediators (eg, peroxynitrite), modifies fibrin(ogen) such that fibrin polymerization is impaired without impacting FXIII-mediated cross-linking. Notably, fibrin(ogen) modified with 3-nitrotyrosine adducts was identified in the APAP-injured liver. In biochemical assays, peroxynitrite inhibited thrombin-mediated fibrin polymerization in a concentration-dependent manner without affecting fibrin(ogen) cross-linking over time. These studies depict a unique pathology wherein thrombin-catalyzed fibrin polymerization is circumvented to allow tissue deposition and FXIII-dependent fibrin(ogen) cross-linking.