bluuebunny/crossref_metadata_2025_split huggingface dataset:
Growth in positive relationship quality with mothers, fathers, and siblings and associations with depressive symptoms and emotionally supportive prosocial behaviors during the transition to adulthood
Authors: Memmott‐Elison Madison K. , Jorgensen McKell A. , Padilla‐Walker Laura M. 
Published: December 2021

AbstractDespite theoretical underpinnings that social influences increase in salience with age, it is currently unclear how relationships with mothers, fathers, and siblings might change during the transition to adulthood and what roles the quality of those relationships play in young adults’ longitudinal adjustment. Therefore, the purpose of the present study was twofold. Firstly, we explored longitudinal growth in positive relationship quality with mothers, fathers, and siblings across the transition to adulthood. Secondly, we assessed comparative associations between positive relationship quality with mothers, fathers, and siblings and young adults’ depressive symptoms and emotionally supportive prosocial behaviors toward strangers and family members from 18 to 20 years. Participants included 402 young adults (51% female; 69.39% White; Mage at T1 = 18.36 years). Mother‐youth positive relationship quality slightly increased during the transition to adulthood, while both father and sibling positive relationship quality remained stable. Young adults with more positive relationship quality with mothers reported experiencing fewer depressive symptoms, and young adults with more positive relationship quality with siblings were more likely to engage in emotionally supportive prosocial behaviors toward both strangers and family members. The increasing strength of mother‐youth relationships during the transition to adulthood and the comparatively salient role of sibling relationships are highlighted.
Turning Points
Authors: Barness Jessica , Papaelias Amy , Sadre‐Orafai Stephanie , Zender Mike 
Published: December 2021

AbstractThis dialogue is part of a cross‐platform collaboration with Visible Language, the oldest peer‐reviewed design journal. Animated by questions about visual methods, genre, form, and analysis—how they differ or converge between design and anthropology, what each field has to offer the other—it contextualizes current issues in academic journal publishing from the perspective of visual studies, social science, and design, fields that do not drive contemporary transformations in journal publishing. It considers the academic journal as a form, editorial labor and politics, reaching audiences beyond the paywall, and measuring the value of scholarship, journals, and visual research.
Partial parotid sialoadenectomy in a horse with parotid ductal carcinoma: Surgical description and case report
Authors: Zetterström Sandra M. , Matz Brad M. , Neto Rachel L. A. L. T. , Lindley Stephanie E. S. , Cole Robert C. , Wilhite Ray , Boone Lindsey H. 
Published: December 2021

AbstractObjectivesTo describe the surgical findings, histopathological features, and long‐term outcome for a horse with parotid salivary carcinoma.Study designCase reportAnimalsTwelve year old American Quarter Horse gelding.MethodsThe gelding was presented for a 10 × 10 cm swelling below the base of the right ear. Ultrasonographic examination revealed a mass involving the right parotid salivary gland. Incisional biopsy was consistent with parotid carcinoma. The tumor was marginally excised. The lateral wall of the guttural pouch was excised with the mass and was reconstructed with a porcine small intestinal submucosal (SIS) sheet. Cisplatin beads were implanted in the wound bed prior to closure. Firocoxib (0.1 mg/kg orally, daily, every 24 h) treatment was initiated.ResultsPostoperative complications included right‐sided facial nerve paralysis, difficulty with deglutition of fibrous feeds, and surgical site dehiscence. Wound healing was achieved by second intention. Partial improvement in nerve function was observed within the first 6 months. At 12 months postparotidectomy, no sign of tumor reoccurrence or metastatic disease was present, and the gelding returned to work.ConclusionPartial parotid sialoadenectomy was performed with a favorable long‐term outcome. Regional anatomic knowledge is crucial.
Understanding Athletic Trainers’ Knowledge, Intervention, and Barriers Toward Arthrogenic Muscle Inhibition
Authors: Rush Justin L. , Sherman David A. , Bazett-Jones David M. , Ingersoll Christopher D. , Norte Grant E. 
Published: December 2021

Context: Arthrogenic muscle inhibition (AMI) is a common neurophysiological response to joint injury. While athletic trainers (ATs) are constantly treating patients with AMI, it is unclear how clinicians are using the available evidence to treat the condition. Objective: To investigate ATs’ general knowledge, clinical practice, and barriers for treating AMI. Methods: A cross-sectional web-based survey was utilized. The survey was distributed to a random sample of 3000 ATs from the National Athletic Trainers’ Association and through social media. 143 board certified ATs (age: 34.6 [10.3] y; experience: 11.7 [9.8] y) from various clinical settings and educational backgrounds were included in the analysis. Results: One hundred one respondents were able to correctly identify the definition of AMI. The majority of these respondents correctly reported that joint effusion (n = 95, 94.1%) and abnormal activity from joint receptors (n = 91, 90.1%) resulted in AMI. Of the 101 respondents, only 58 (57.4%) reported using disinhibitory interventions to treat AMI. The most frequently used evidence supported interventions were transcutaneous electrical nerve stimulation (n = 38, 65.5%), neuromuscular electrical stimulation (n = 33, 56.9%), and focal joint cooling (n = 25, 43.1%). The interventions used correctly most often based on current evidence were neuromuscular electrical stimulation (n = 29/33, 87.9%) and transcutaneous electrical nerve stimulation (n = 26/38, 68.4%). Overall, difficulty quantifying AMI (n = 62, 61.24%) and lack of education (n = 71, 76.2%) were most frequently perceived as barriers. Respondents that did not use disinhibitory interventions perceived lack of experience treating AMI, understanding the terminology, and access to therapeutic modalities more often than the respondents that reported using disinhibitory interventions. Conclusion: Further education about concepts and treatment about AMI is warranted for ATs. Continued understanding of ATs’ clinical practice in regard to AMI may help identify gaps in athletic training clinical education.
First structural observation around the hinge of the Mongolian Orocline (Central Asia): Implications for the geodynamics of oroclinal bending and the evolution of the Mongol-Okhotsk Ocean
Authors: Li Pengfei , Sun Min , Narantsetseg Tserendash , Jourdan Fred , Hu Wanwan , Yuan Chao 
Published: December 2021

ABSTRACT
To understand the origin of curved subduction zones has been one of the major challenges in plate tectonics. The Mongol-Okhotsk Orogen in Central Asia is characterized by the development of a U-shaped oroclinal structure that was accompanied by the continuous subduction of the Mongol-Okhotsk oceanic plate. Therefore, it provides a natural laboratory to understand why and how a subduction system became tightly curved. In this study, we provide the first structural observation around the hinge of the Mongolian Orocline (the Zag zone in Central Mongolia), with an aim to constrain the oroclinal geometry and to link hinge zone structures with the origin of the orocline. Our results show that rocks in the Zag zone are characterized by the occurrence of a penetrative foliation that is commonly subparallel to bedding. Both bedding and dominant fabric in the Zag zone are steeply dipping, and their strike orientations in a map view follow a simple curve around the hinge of the Mongolian Orocline, thus providing the first structural constraint for 3D geometry of the orocline. A secondary penetrative fabric parallel to the axial plane of the orocline was not observed, indicating a low degree of orogen-parallel shortening during oroclinal bending. Combining with available geological and geophysical data, we conclude that the Mongolian Orocline was developed in a period of Permian to Jurassic, and its origin was linked to the subduction of the Mongol-Okhotsk oceanic slab. We consider that the low-strain oroclinal bending likely resulted from the along-strike variation in trench retreat, which was either triggered by the negative buoyancy of the Mongol-Okhotsk oceanic slab, or driven by the relative rotation of the Siberian and North China cratons. Our results shed a light on 3D geometry and geodynamic mechanisms of large-scale oroclinal bending in an accretionary orogen.
Possible shock-induced crystallization of skeletal quartz from supercritical SiO2-H2O fluid: A case study of impact melt from Kamil impact crater, Egypt
Authors: Fazio Agnese , Folco Luigi , Langenhorst Falko 
Published: December 2021

Abstract
Since its discovery, the Kamil crater (Egypt) has been considered a natural laboratory for studying small-scale impact cratering. We report on a previously unknown shock-related phenomenon observed in impact melt masses from Kamil; that is, the shock-triggered formation of skeletal quartz aggregates from silica-rich fluids. These aggregates are unshocked and characterized by crystallographically oriented lamellar voids and rounded vesicles. The distribution of the aggregates can be correlated with former H2O- and impurity-rich heterogeneities in precursor quartz; i.e., fluid inclusions. The heterogeneities acted as hot spots for local melting. Due to the presence of H2O and the high impact pressure and temperature, the formation of a localized supercritical fluid is plausible. Below the upper critical end point of the SiO2–H2O system (temperature &lt;1100 °C and pressure &lt;1 GPa), SiO2 melt and H2O fluid become immiscible, leading to the rapid and complete crystallization of skeletal quartz.
Preferential dissolution of uranium-rich zircon can bias the hafnium isotope compositions of granites
Authors: Gao Peng , Yakymchuk Chris , Zhang Jian , Yin Changqing , Qian Jiahui , Li Yanguang 
Published: December 2021

Abstract
Hafnium (Hf) isotopes in zircon are important tracers of granite petrogenesis and continental crust evolution. However, zircon in granites generally shows large Hf isotope variations, and the reasons for this are debated. We applied U-Pb geochronology, trace-element, and Hf isotope analyses of zircon from the Miocene Himalayan granites to address this issue. Autocrystic zircon had εHf values (at 20 Ma) of–12.0 to–4.3 (median =–9). Inherited zircon yielded εHf values (at 20 Ma) of–34.8 to +0.3 (median =–13); the majority of εHf values were lower than those of autocrystic zircon. The εHf values of inherited zircon with high U concentrations resembled those of autocrystic zircon. Geochemical data indicates that the granites were generated during relatively low-temperature (&lt;800 °C) partial melting of metasedimentary rocks, which, coupled with kinetic hindrance, may have led to the preferential dissolution of high-U zircon that could dissolve more efficiently into anatectic melt due to higher amounts of radiation damage. Consequently, Hf values of autocrystic zircon can be biased toward the values of U-rich zircon in the source. By contrast, literature data indicate that granites generated at high temperatures (&gt;820–850 °C) generally contain autocrystic and inherited zircons with comparable Hf isotope values. During higher-temperature melting, indiscriminate dissolution of source zircon until saturation is reached will result in near-complete inheritance of Hf isotope ratios from the source. Our results impose an extra layer of complexity to interpretation of the zircon Hf isotope archive that is not currently considered.
Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells
Authors: Zhao Songbo , Wang Chunhua , Lu Ping , Lou Yalin , Liu Huimin , Wang Ting , Yang Shanshan , Bao Ziyou , Han Lin , Liang Xiaohong , Ma Chunhong , Gao Lifen 
Published: December 2021

BackgroundChimeric antigen receptor (CAR) T cells have been successfully used in tumor immunotherapy due to their strong antitumor responses, especially in hematological malignancies such as B cell acute lymphoid leukemia. However, on-target off-tumor toxicity and poor persistence severely limit the clinical application of CAR-T cell therapy.MethodsT-cell immunoglobulin mucin domain molecule 3 (TIM-3) was used to develop a second-generation 41BB CD19 CAR linked with a T3/28 chimera, in which truncated extracellular TIM-3 was fused with the CD28 transmembrane and cytoplasmic domains. The efficacy of T3/28 CAR-T cells was evaluated in vitro and in vivo.ResultsWe demonstrated that the switch receptor T3/28 preserved the TCMphenotype, improved proliferative capacity, and reduced exhaustion of CAR-T cells, resulting in superior in vitro and in vivo antitumor activity in B lymphoma. Importantly, the switch receptor T3/28 substantially prolonged the persistence of CAR-T cells, and the interleukin-21/Stat3 axis probably contributed to the enhanced cytotoxicity of T3/28 CAR-T cells.ConclusionOverall, the T3/28 chimera significantly prolonged the persistence of CAR-T cells, and T3/28 CAR-T cells possessed potent antitumor activity in mice, shedding new light on potential improvements in adoptive T cell therapies.
Comparison of contralateral oblique view with the lateral view for fluoroscopic-guided cervical epidural steroid injection: a randomized clinical trial
Authors: Sim Ji-Hoon , Kwon Hyun-Jung , Kim Chan-Sik , Kim Eun Ha , Kim Doo-Hwan , Choi Seong-Soo , Shin Jin-Woo 
Published: December 2021

BackgroundCervical epidural steroid injection is associated with rare but potentially catastrophic complications. The contralateral oblique (CLO) view may be a safe and feasible alternative to the lateral (LAT) view for fluoroscopic-guided cervical epidural steroid injection. However, evidence for the clinical usefulness of the CLO view for cervical epidural steroid injection is lacking. We assessed the clinical usefulness of the CLO view for cervical epidural steroid injection in managing cervical herniated intervertebral discs.MethodsPatients were randomly assigned to receive fluoroscopic-guided cervical epidural steroid injection under LAT view or CLO view at 50±5° degrees groups. The primary outcome was the needling time comparison between the two groups. Secondary outcomes were comparison of first-attempt success rate, needle tip visualization and location, total number of needle passes, final success rate, crossover success rate and false-positive/negative loss of resistance. Complications and radiation dose were also compared.ResultsThe needling time significantly decreased in the CLO than in the LAT group. The first-attempt success rate was significantly higher in the CLO compared with the LAT group. The needle tip was clearly visualized (p<0.001) and located more often on (or just anterior to) the ventral interlaminar line (p<0.001) in the CLO than in the LAT group. There were significantly fewer needle passes (p=0.019) in the CLO than in the LAT group. There were no significant differences in the final success, crossover success, false-positive/negative loss of resistance or radiation dose between the groups. Two (5.9%) cases in the LAT group experienced complications.ConclusionThe CLO view may be recommended for fluoroscopic-guided cervical epidural steroid injection, considering its better clinical usefulness over the LAT view.
Effectiveness of Insole Colour on Impact Loading and Lower-Limb Kinematics When Running at Preferred and Nonpreferred Speeds
Authors: Wang Yi , Lam Wing-Kai , Pak Lok-Yee , Wong Charis K.-W. , Tan Mohammad F. , Leung Aaron K.-L. 
Published: December 2021

While colour of red can play a significant role in altering human perception and performances, little is known about its perceptual-motor effect on running mechanics. This study examined the effects of variations in insole colours on impact forces, ankle kinematics, and trial-to-trial reliability at various running speeds. Sixteen male recreational runners ran on instrumented treadmill at slow (90%), preferred (100%), and fast (110%) running speeds when wearing insoles in red, blue, and white colours. We used synchronized force platform and motion capturing system to measure ground reaction force, ankle sagittal and frontal kinematics, and movement variability. A two-way (colour x speed) ANOVA with repeated measures was performed with Bonferroni adjusted post hoc comparisons, with alpha set at 0.05. Data analyses indicated that participants demonstrated higher impact and maximum loading rate of ground reaction force, longer stride length, shorter contact time, and smaller touchdown ankle inversion as well as larger ankle sagittal range of motion (RoM), but smaller frontal RoM in fast speed as compared with preferred

P
<
0.05

and slow speeds

P
<
0.001

. Although insole colour had minimal effect on mean values of any tested variables

P
>
0.05

, participants wearing red-coloured orthoses showed higher coefficient of variation values for maximum loading rate than wearing blue insoles

P
=
0.009

. These results suggest that running at faster speed would lead to higher impact loading and altered lower-limb mechanics and that colour used on the tops of insoles influences the wearers’ movement repeatability, with implications for use of foot insole in running.
PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress
Authors: Klopotowska Marta , Bajor Malgorzata , Graczyk-Jarzynka Agnieszka , Kraft Agnieszka , Pilch Zofia , Zhylko Andriy , Firczuk Malgorzata , Baranowska Iwona , Lazniewski Michal , Plewczynski Dariusz , Goral Agnieszka , Soroczynska Karolina , Domagala Joanna , Marhelava Katsiaryna , Slusarczyk Aleksander , Retecki Kuba , Ramji Kavita , Krawczyk Marta , Temples Madison N. , Sharma Blanka , Lachota Mieszko , Netskar Herman , Malmberg Karl-Johan , Zagozdzon Radoslaw , Winiarska Magdalena 
Published: December 2021

AbstractOxidative stress, caused by the imbalance between reactive species generation and the dysfunctional capacity of antioxidant defenses, is one of the characteristic features of cancer. Here, we quantified hydrogen peroxide in the tumor microenvironment (TME) and demonstrated that hydrogen peroxide concentrations are elevated in tumor interstitial fluid isolated from murine breast cancers in vivo, when compared with blood or normal subcutaneous fluid. Therefore, we investigated the effects of increased hydrogen peroxide concentration on immune cell functions. NK cells were more susceptible to hydrogen peroxide than T cells or B cells, and by comparing T, B, and NK cells' sensitivities to redox stress and their antioxidant capacities, we identified peroxiredoxin-1 (PRDX1) as a lacking element of NK cells' antioxidative defense. We observed that priming with IL15 protected NK cells' functions in the presence of high hydrogen peroxide and simultaneously upregulated PRDX1 expression. However, the effect of IL15 on PRDX1 expression was transient and strictly dependent on the presence of the cytokine. Therefore, we genetically modified NK cells to stably overexpress PRDX1, which led to increased survival and NK cell activity in redox stress conditions. Finally, we generated PD-L1–CAR NK cells overexpressing PRDX1 that displayed potent antitumor activity against breast cancer cells under oxidative stress. These results demonstrate that hydrogen peroxide, at concentrations detected in the TME, suppresses NK cell function and that genetic modification strategies can improve CAR NK cells' resistance and potency against solid tumors.
A Thesaurus of Old English
Authors: Roberts Jane 
Published: December 2021

Abstract
The Thesaurus of Old English (TOE), first published in 1995, had its origins in a body of slips derived from standard dictionaries, principally the Clark Hall and Merritt Concise Anglo-Saxon Dictionary and the Bosworth-Toller volumes. These slips were made to supply the Glasgow Historical Thesaurus (HT) project (1965–2009) with a firmer idea of the range and totality of Old English vocabulary than available in the OED. In 1976 the decision was taken to deploy the Old English materials as a pilot thesaurus for the HT. With compilation of the slips completed in 1982, researchers were able to begin sorting the slips into groupings based on meaning and to see areas of the HT classification take shape in miniature. The TOE data, absorbed into the larger structure of its parent project, allow us to view English words that disappeared by 1150 alongside those that continued in use.
Characterization of ground parenchyma cells in Moso bamboo (Phyllostachys edulis–Poaceae)
Authors: Lian Caiping , Chen Hong , Zhang Shuqin , Liu Rong , Wu Zhihui , Fei Benhua 
Published: December 2021

Summary
Ground parenchyma cells play a crucial role in the growth and the mechanical properties of bamboo plants. Investigation of the morphology of ground parenchyma cells is essential for understanding the physiological functions and mechanical properties of these cells. This study aimed to characterize the anatomical structure of bamboo ground parenchyma cells and provide a qualitative and quantitative basis for the more effective utilization of bamboo. To do this, the morphology of ground parenchyma cells in Moso bamboo (Phyllostachys edulis) was studied using light microscopy and field-emission environmental scanning electron microscopy. Results show that various geometric shapes of ground parenchyma cells were observed, including nearly circular, square, long, oval, and irregular shapes. Cell walls of both long and short parenchyma cells exhibited primary wall thickening and secondary wall thickening, resulting in a primary pit field and simple pits. Most long cells were strip-shaped (L/W = 2.52), while most short cells were short and wide (L/W = 0.59). The proportion of long cells was 11 times greater than that of short cells. Most long cells were filled with starch grains, and some short cells also occasionally had starch grains. These findings allowed the first construction of the three-dimensional structure of parenchyma cells.