bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomatrix of health risk assessment of benzene-exposed workers at Thai gasoline stations
Authors: Chaiklieng Sunisa , Suggaravetsiri Pornnapa , Autrup Herman 
Published: December 2021

Abstract

Objective
This study assessed the health risk of benzene exposure among Thai gasoline station workers through biomarker detection and experience of adverse symptoms.

Methods
Trans, trans-muconic acid (tt-MA) metabolites of benzene were analyzed from spot urine sampled among gasoline station workers after shift work using HPLC-UV. Air benzene monitoring was done with an active sampler connected to a charcoal sorbent tube, and analyzed by GC-FID. The health risk was calculated by using the biomatrix of the likelihood of benzene exposure and the severity of adverse symptoms.

Results
The tt-MA concentration, among 235 workers, ranged from less than 10–2159 µg/g Cr, which corresponded to the air benzene concentration range of &lt;0.1 to 65.8 ppb. In total, 32.3% of workers had a higher than acceptable risk level and there was a significant association between gasoline station work zones and the likelihood of benzene exposure as well as the health risk of workers. The health risk levels estimated from the biomarker monitoring were consistent with the risk matrix of air benzene monitoring.

Conclusion
This tt-MA biomarker monitoring and biomatrix of health risk assessment is suggested as useful for health surveillance of gasoline station workers exposed to benzene.
Copper Complexes as Anticancer Agents
Authors: De Franco Michele , Porchia Marina , Tisato Francesco , Marzano Cristina , Gandin Valentina 
Published: December 2021

Abstract

Following the great impetus provided by the discovery of the anticancer activity of cisplatin [
cis
‐diamminedichloridoplatinum(II)] in the 1960s, extensive search for alternative metal‐based drugs with improved pharmacological properties has been attempted. Actually, the outstanding efficacy showed by clinically approved Pt(II) compounds is counterbalanced by severe toxic effects on normal tissues, and by the early appearance of drug resistance phenomena. Among non‐Pt compounds, copper complexes are considered promising alternatives to platinum drugs as antitumor agents. In particular, the discovery of significant alterations in cancer cell copper metabolism and the different responses to copper between normal and tumor cells have paved the way for the development of copper‐based anticancer drugs. This article aims to summarize the extant literature on the most well‐studied classes of anticancer copper complexes, with special emphasis on research performed in the last 10 years, most relevant to the elucidation of the involved mechanisms of action and/or reporting on in vivo efficacy evaluations.
HDAC6 Inhibition Corrects Electrophysiological and Axonal Transport Deficits in a Human Stem Cell‐Based Model of Charcot‐Marie‐Tooth Disease (Type 2D)
Authors: Smith Alec S.T. , Kim Jong Hyun , Chun Changho , Gharai Ava , Moon Hyo Won , Kim Eun Young , Nam Soo Hyun , Ha Nina , Song Ju Young , Chung Ki Wha , Doo Hyun Myung , Hesson Jennifer , Mathieu Julie , Bothwell Mark , Choi Byung‐Ok , Kim Deok‐Ho 
Published: December 2021

AbstractCharcot‐Marie‐Tooth disease type 2D (CMT2D), is a hereditary peripheral neuropathy caused by mutations in the gene encoding glycyl‐tRNA synthetase (GARS1). Here, human induced pluripotent stem cell (hiPSC)‐based models of CMT2D bearing mutations in GARS1 and their use for the identification of predictive biomarkers amenable to therapeutic efficacy screening is described. Cultures containing spinal cord motor neurons generated from this line exhibit network activity marked by significant deficiencies in spontaneous action potential firing and burst fire behavior. This result matches clinical data collected from a patient bearing a GARS1P724H mutation and is coupled with significant decreases in acetylated α‐tubulin levels and mitochondrial movement within axons. Treatment with histone deacetylase 6 inhibitors, tubastatin A and CKD504, improves mitochondrial movement and α‐tubulin acetylation in these cells. Furthermore, CKD504 treatment enhances population‐level electrophysiological activity, highlighting its potential as an effective treatment for CMT2D.
Repeated Recovery of Rare Earth Elements Using a Highly Selective and Thermo‐Responsive Genetically Encoded Polypeptide
Authors: Hussain Zohaib , Kim Seoungkyun , Cho Jinhwan , Sim Gyudae , Park Youngjune , Kwon Inchan 
Published: December 2021

AbstractRare earth elements (REEs) have become increasingly important materials owing to their use in the high‐tech and clean‐energy industries. However, the unpredictable supply, possible health risks, and environmentally unsustainable extraction practices associated with REEs have encouraged the development of green technologies for the selective extraction and recovery of metals. This study presents a simple and innovative approach for the selective extraction and recovery of total REEs. Elastin‐like polypeptide (ELP) and the REE‐binding domain (lanmodulin) are fused to form REEs‐sensitive and thermo‐responsive genetically encoded ELP called RELP, where ELP offered a reversible, inverse phase transition for repeated uses. The RELP are purified and used for the selective extraction of total REEs from competing non‐REEs metals by controlling the solution temperature (4 and 37 °C) and pH. RELP exhibit high REE specificity, even in the presence of non‐REE metal ions. The bound REEs are readily recovered during at least six repeated cycles, and the efficiency is maintained. Moreover, REEs are selectively recovered by RELP from steel slag leachate, a potential industrial source of REEs. RELP offers a rapid, selective, and scalable method for REE extraction and recovery. This technology can be adapted to recover other precious metals and commodities.
Reversing Hydrogel Adhesion Property via Firmly Anchoring Thin Adhesive Coatings
Authors: Feng Haiyan , Ma Yanfei , Zhang Zhizhi , Yang Song , Ma Zhengfeng , Zhang Yunlei , Ma Shuanhong , Yu Bo , Cai Meirong , Pei Xiaowei , Zhou Feng 
Published: December 2021

AbstractHydrogels, exhibiting wide application prospects in soft robotics, tissue engineering, implantable electronics, etc., upon functioning often require to adhere to substrates especially in wet environments despite that most hydrogels are nonsticky because of their high water content and hydrophilicity. Herein, a strategy to rapidly reverse the adhesion properties of hydrogels via surface anchoring very thin adhesive coatings is reported. Inspired by mussel adhesion, poly(vinyl alcohol) hydrogel is first coated with polymerized tannic acid that chelates with Fe3+, which serves as the interface bonding layer. Subsequently, a wet adhesive poly(dopamine methacrylamide‐co‐methoxyethyl acrylate) is firmly anchored to form the very thin adhesive coating (<10 µm) that can generate high adhesion strength both in the air and underwater. The adhesive coating also endows hydrogels with high water retention capacity under warm condition (50 °C) and is able to get on‐demand functionalization on the designated area to achieve asymmetric adhesion, static and dynamic control over wettability. The strategy demonstrates potentials for broad applications from biomedicine to wearable electronics.
Au@Ag Nanorods‐PDMS Wearable Mouthguard as a Visualized Detection Platform for Screening Dental Caries and Periodontal Diseases
Authors: Ma Dongxu , Chen Baiqi , Li Yuanfang , Pang Xueyuan , Fu Quanying , Xiao Zihan , Shi Zhonghong , Li Xiaolei , Luo Chongdai , Zhou Zhang‐kai , Chen Yin , Zhou Jianhua 
Published: December 2021

AbstractThe development of easy‐to‐use, low‐cost, and visualized detection platforms for screening human dental caries and periodontal diseases is in urgent demand. In this work, a Au@Ag nanorods‐poly(dimethylsiloxane) (Au@Ag NRs‐PDMS) wearable mouthguard, which can visualize the tooth lesion sites through the color change of it at the corresponding locations, is presented. The Au@Ag NRs‐PDMS composite exhibits a distinct color response to hydrogen sulfide (H2S) gas generated by bacterial decay at the lesion sites. Moreover, the Au@Ag NRs‐PDMS mouthguard is demonstrated to own desired mechanical properties, excellent chemical stability, as well as good biocompatibility, and can accurately locate the lesion sites in human oral cavity. These findings suggest that the mouthguard has the potential to be utilized on a large scale to help people self‐monitor their oral health in daily life, and treat oral diseases locally.
Artificial Nacre with High Toughness Amplification Factor: Residual Stress‐Engineering Sparks Enhanced Extrinsic Toughening Mechanisms
Authors: Meng Yu‐Feng , Zhu Yin‐Bo , Zhou Li‐Chuan , Meng Xiang‐Sen , Yang Yu‐Lu , Zhao Ran , Xia Jun , Yang Bo , Lu Yu‐Jie , Wu Heng‐An , Mao Li‐Bo , Yu Shu‐Hong 
Published: December 2021

AbstractThe high fracture toughness of mollusk nacre is predominantly attributed to the structure‐associated extrinsic mechanisms such as platelet sliding and crack deflection. While the nacre‐mimetic structures are widely adopted in artificial ceramics, the extrinsic mechanisms are often weakened by the relatively low tensile strength of the platelets with a large aspect ratio, which makes the fracture toughness of these materials much lower than expected. Here, it is demonstrated that the fracture toughness of artificial nacre materials with high inorganic contents can be improved by residual stress‐induced platelet strengthening, which can catalyze more effective extrinsic toughening mechanisms that are specific to the nacre‐mimetic structures. Thereby, while the absolute fracture toughness of the materials is not comparable with advanced ceramic‐based composites, the toughness amplification factor of the material reaches 16.1 ± 1.1, outperforming the state‐of‐the‐art biomimetic ceramics. The results reveal that, with the merit of nacre‐mimetic structural designs, the overall fracture toughness of the artificial nacre can be improved by the platelet strengthening through extrinsic toughening mechanisms, although the intrinsic fracture toughness may decrease at platelet level due to the strengthening. It is anticipated that advanced structural ceramics with exceeding performance can be fabricated through these unconventional strategies.
Achieving Ultraviolet C and Ultraviolet B Dual‐Band Persistent Luminescence by Manipulating the Garnet Structure
Authors: Wang Xianli , Mao Yuanbing 
Published: December 2021

AbstractPersistent luminescence (PersL) at the high‐energy spectral end (ultraviolet, UV) is generally hard to achieve, although a long‐lasting UV PersL can play an irreplaceable role in outdoor imaging and other UV‐triggered applications. No PersL with dual ultraviolet C (UVC) and ultraviolet B (UVB) bands from a single material has previously been attained until the authors have designed Pr3+‐doped (Ca1.5Y1.5)(Al3.5Si1.5)O12 (CYAS‐Pr) through cosubstituting Ca2+–Si4+ into Y3Al5O12 garnet structure in this study. The CYAS‐Pr exhibits lattice shrinkage and distortion caused by the Ca2+–Si4+ cosubstitution, which boosts the creation of trapping centers essential to the unprecedented UVC and UVB dual‐band PersL with maxima at 266 and 311 nm upon being charged by UV irradiation at 254 nm. Both UVC and UVB PersL decay over 12 h with the existence of two different Pr3+ environments at Ca2+ and Y3+ sites, respectively. Moreover, the CYAS‐Pr shows efficient dual information storage and precise long‐distance self‐sustained “solar‐blind” imaging capabilities in a wide field of view. It is expected that this dual UVC and UVB PersL in the CYAS‐Pr will trigger further exploration toward persistent sterilization and persistent photocatalysis along with other applications.
Quadruple Anti‐Counterfeiting Retroreflective Structural Color Films
Authors: Ji Cuiping , Chen Min , Wu Limin 
Published: December 2021

AbstractWhile structural color materials are widely exploited in anti‐counterfeiting applications, it still remains a challenge to develop advanced and multifunctional structural colors for new anti‐counterfeiting technologies. Herein, a novel patterned retroreflective structural color film (PRSCF) with quadruple anti‐counterfeiting capacities is reported based on the changes in iridescent and non‐iridescent colors due to total internal reflection and interference mechanisms, reversible thermal‐responsive patterns owing to the shape memory effect, and reversible decryption and encryption of the patterns due to the surface wettability difference. This quadruple anti‐counterfeiting PRSCF greatly improves the security level and may find important potentials in precious artworks and displays.
FasL+PD‐L2+ Identifies a Novel Immunosuppressive Neutrophil Population in Human Gastric Cancer That Promotes Disease Progression
Authors: Shan Zhi‐Guo , Zhao Yong‐Liang , Zhang Jin‐Yu , Yan Zong‐Bao , Wang Ting‐Ting , Mao Fang‐Yuan , Teng Yong‐Sheng , Peng Liu‐Sheng , Chen Wan‐Yan , Wang Pan , Cheng Ping , Tian Wen‐Qing , Chen Jun , Chen Weisan , Zhuang Yuan 
Published: December 2021

AbstractNeutrophils constitute abundant cellular components in human gastric cancer (GC) tissues, but their protumorigenic subset in pathogenesis of GC progression is unclear. Here, it is found that patients with GC show significantly higher neutrophil infiltration in tumors that is regulated by CXCL12‐CXCR4 chemotaxis. These tumor‐infiltrating neutrophils express high level immunosuppressive molecules FasL and PD‐L2, and this FasL+PD‐L2+ neutrophil subset with a unique phenotype constitutes at least 20% of all neutrophils in advanced GC and predicts poor patient survival. Tumor induces neutrophils to express FasL and PD‐L2 proteins with similar phenotype to those in GC tumors in both time‐dependent and dose‐dependent manners. Mechanistically, Th17 cell‐derived IL‐17A and tumor cell‐derived G‐CSF can significantly induce neutrophil FasL and PD‐L2 expression via activating ERK‐NF‐κB and JAK‐STAT3 signaling pathway, respectively. Importantly, upon over‐expressing FasL and PD‐L2, neutrophils acquire immunosuppressive functions on tumor‐specific CD8+ T‐cells and promote the growth and progression of human GC tumors in vitro and in vivo, which can be reversed by blocking FasL and PD‐L2 on these neutrophils. Thus, the work identifies a novel protumorigenic FasL+PD‐L2+ neutrophil subset in GC and provides new insights for human cancer immunosuppression and anti‐cancer therapies targeting these pathogenic cells.
Engineering the Hole Extraction Interface Enables Single‐Crystal MAPbI3 Perovskite Solar Cells with Efficiency Exceeding 22% and Superior Indoor Response
Authors: Li Ning , Feng Anbo , Guo Xinbo , Wu Jinming , Xie Shengdan , Lin Qinglian , Jiang Xiaomei , Liu Yang , Chen Zhaolai , Tao Xutang 
Published: December 2021

AbstractPerovskite single crystals have recently been regarded as emerging candidates for photovoltaic application due to their improved optoelectronic properties and stability compared to their polycrystalline counterparts. However, high interface and bulk trap density in micrometer‐thick thin single crystals strengthen unfavorable nonradiative recombination, leading to large open‐circuit voltage (VOC) and energy loss. Herein, hydrophobic poly(3‐hexylthiophene) (P3HT) molecule is incorporated into a hole transport layer to interact with undercoordinated Pb2+ and promote ion diffusion in a confined space, resulting in higher‐quality thin single crystals with reduced interface and bulk defect density, suppressed nonradiative recombination, accelerated charge transport, and extraction. As a result, a remarkably enhanced VOC of up to 1.13 V and efficiency of 22.1% are achieved, which are both the highest values for MAPbI3 single‐crystal solar cells. Moreover, the reduced defect density and suppressed carrier recombination lead to superior weak light response of the single‐crystal solar cells after incorporation of P3HT, and an indoor photovoltaic efficiency of 39.2% at 1000 lux irradiation is obtained.
Hückel‐ and Baird‐Type Global Aromaticity in a 3D Fully Conjugated Molecular Cage
Authors: Wu Shaofei , Ni Yong , Han Yi , Hou Xudong , Wang Congyong , Hu Wenping , Wu Jishan 
Published: December 2021

AbstractGlobal aromaticity in 3D π‐conjugated molecular cages remains largely unexplored. Herein, we report the facile synthesis of a fully conjugated molecular cage (1) containing two bridged triphenylamine units and three quinoidal bithiophene arms. X‐ray crystallographic analysis, NMR/ESR measurements and theoretical calculations reveal that: 1) its dication (12+) has an open‐shell singlet ground state and is 3D globally aromatic, with individual macrocycles being 2D Hückel aromatic; 2) its tetracation (14+) has a triplet ground state and is also 3D globally aromatic, with individual macrocycles being 2D Baird aromatic; and 3) its hexacation (16+) has a closed‐shell nature and shows local aromaticity. The study demonstrated a close relationship between 2D Hückel/Baird aromaticity and 3D global π‐aromaticity.
Infection Transmission Associated With Contaminated Ultrasound Probes: A Systematic Review
Authors: de Souza Hajar Karina , Quartim de Moraes Bruna Camila , Uchikawa Graziano Kazuko 
Published: December 2021

ABSTRACTA systematic review of seven studies on infections related to contaminated ultrasound probes showed that the infections were related to a failure in the decontamination process of ultrasound devices used on immature skin of neonates in an intensive care unit and transesophageal echocardiography probes. Six of the studies involved outbreaks in patients who underwent transesophageal echocardiography either during or after surgery or as a part of treatment for a nonsurgical cardiac condition. The evidence shows links between the infection outbreaks and environmental contamination, lack of standardized ultrasound probe disinfection processes, inadequate storage, and lack of monitoring of probe integrity. When personnel addressed the deficiencies (eg, improving the disinfection process, cleaning the probes immediately after use, inspecting the probes for defects), the infections ceased. Personnel involved with the reprocessing of ultrasound probes should clean, disinfect, inspect, and store ultrasound probes in a manner that maintains device integrity and prevents contamination.
Improving Skin Assessment Documentation in the Electronic Health Record to Prevent Perioperative Pressure Injuries
Authors: Monfre Jill , Batchelor Frances , Skar Anne 
Published: December 2021

ABSTRACTPerioperative leaders at a pediatric trauma hospital initiated an examination of the existing processes for pressure injury prevention. They assembled a workgroup comprising a wound and skin clinical nurse specialist, a nursing informatics specialist, and a perioperative nurse specialist who applied a proven change management framework to guide their efforts. The workgroup identified a critical gap in the documentation features in the electronic health record: nurses were unable to communicate skin assessment and pressure injury information easily and consistently across services (eg, inpatient, emergency department, surgical services). Using evidence from nursing and pressure injury associations on skin assessments, interventions, and documentation, the workgroup developed, trialed, and implemented updated documentation fields, making them consistent throughout the electronic health record. Based on postimplementation survey responses, nurses at the hospital are highly satisfied with the changes. The surgically acquired pressure injury rate at the hospital continues to remain low.
An Overview of Dupuytren’s Disease for Perioperative Nurses
Authors: Russell Mary C. 
Published: December 2021

ABSTRACTDupuytren’s disease is a fibroproliferative condition that causes shortening, thickening, and fibrosis of the palmar fascia and a flexion deformity of metacarpophalangeal and proximal interphalangeal joints. Although the etiology is unknown, a variety of risk factors, such as age greater than 50 years, male sex, family history, or tobacco and alcohol use may lead to disease development. At the present time there is no cure and symptoms may recur; however, surgical procedures (eg, limited fasciectomy) and nonsurgical treatment (eg, needle aponeurotomy, injection of collagenase clostridium histolyticum) can help patients manage the disease’s symptoms. Patients may experience wound‐healing complications after fasciectomy and skin fissures after needle aponeurotomy. Recurrence rates for needle aponeurotomy and collagenase clostridium histolyticum injection are similar. Perioperative nurses should provide individualized patient care during procedures, participate in effective team communication regarding patient needs, and provide patient education throughout the perioperative continuum.
High‐performance fiber‐reinforced composites with a polydopamine/epoxy silane hydrolysis‐condensate bilayer on surface of ultra‐high molecular weight polyethylene fiber
Authors: Zhang Yao , Cao Shao , Zhou Xiaochen , Kong Fanmin , Li Huaidong , Jiang Guodong 
Published: December 2021

AbstractA bilayer structure with polydopamine (PDA) transition layer and 3‐glycidyl ether oxy‐propyl trimethoxy silane (GOPTS) hydrolysis‐condensate strengthened layer on the surface of ultra‐high molecular weight polyethylene (UHMWPE) fiber is prepared to improve the damage resistance of composites and more efficient stress transmission in composites. PDA is covered on the surface of UHMWPE fiber and then GOPTS is hydrolyzed and condensed to form inorganic ‐O‐Si‐O‐ with epoxy groups on the PDA layer. In addition, the surface activated nano‐SiO2 is dispersed in the epoxy resin to increase the strength of the matrix resin. The results show that the interfacial shear strength (IFSS), the impact strength, the flexural strength and flexural modulus of UHMWPE‐PDA‐GOPTS/EP‐SiO2 increase by 99.1%, 54.1%, 76.8%, and 36.6% respectively compared with unmodified UHMWPE/EP. The chemical compositions of the treated fiber surface are characterized by X‐ray photoelectron spectroscopy and Fourier transform infrared spectroscopy (ATR‐FTIR). With the help of the scanning electron microscopy, the interface failure and reinforcement mechanism of the composites are further explored due to UHMWPE fiber shear yield deformation, UHMWPE fiber fracture, matrix resin cracking and the relative sliding friction between the fiber and matrix.