bluuebunny/crossref_metadata_2025_split huggingface dataset:
Video‐assisted reflection: improving OSCE feedback
Authors: Mitchell Oliver , Cotton Natalia , Leedham‐Green Kathleen , Elias Salem , Bartholomew Brent 
Published: May 2021

AbstractBackgroundObjective Structured Clinical Examinations (OSCEs) are commonly used to provide feedback to students on their performance in formative examinations. However, students are often unable to act independently on the feedback they receive. This study explored how the use of video‐assisted reflection in OSCEs can enhance students’ ability to reflect and engage in sustainable feedback.MethodsTwenty‐one students undertaking a mock‐final OSCE consented to have one of their examination stations filmed. Participants completed a series of reflective forms immediately after the OSCE, after verbal feedback from an examiner and finally, after watching the video of their own performance. Students were asked to predict their overall grade as well as list areas for improvement. Pearson r correlations examined the relationship between the examiners’ grades and the candidates’ self‐predicted grades. Wilcoxon signed‐rank tests were used to compare the length of reflections at each stage. Semi‐structured interviews were conducted to explore students’ beliefs on self‐efficacy and how the video‐assisted reflection altered their ability to act on feedback.ResultsThe students’ ability to self‐assess and gauge their own performance improved significantly after undertaking the video‐assisted reflection (p < 0.01). Furthermore, video‐assisted reflection significantly increased the length of the student's reflections.In interviews, participants described multiple ways in which the video‐assisted reflection improved their confidence and ability to act on feedback, highlighting a clear enhancement in self‐efficacy.DiscussionVideo‐assisted reflection of recorded OSCE stations represents an effective approach to increase student self‐efficacy and subsequently improve engagement in sustainable feedback practice.
Positional error modeling of sky‐view factor measurements within urban street canyons
Authors: Wang Zian , Tang Guoan , Lü Guonian , Ye Cheng , Zhou Fangzhuo , Zhong Teng 
Published: May 2021

AbstractThe sky‐view factor (SVF) in the urban street canyon is a single point‐specific measurement that can only represent the ratio of the visible sky of a specific point. The positional error of the SVF observation point (PE‐SVFOP) to the measurement of the SVF for specific applications is often ignored. This study conducted a quantitative exploration of the positional error in SVF measurements (PE‐SVF) by comparing the SVF estimated at the desired SVF observation point and the corresponding actual SVF observation point. A numerical geometric‐based method was applied in urban street canyons with five typical aspect ratios to explore the effect of both the lateral and vertical positional error of SVF observation points on the measurement of SVF. An empirical case study using a simulation‐based method was then conducted with a 3D city model of a typical street canyon in Hong Kong. The empirical results show that the average and maximum PE‐SVFs were −0.0051 and 0.0181, respectively, and the average and maximum relative PE‐SVFs (RPE‐SVFs) were 7.68 and 20.37%, respectively. An open‐source toolbox was developed to evaluate the PE‐SVF and RPE‐SVF, which can assist specific SVF applications with a more comprehensive consideration of the PE‐SVF.
Health outcomes in international migrant children: protocol for a systematic review
Authors: Armitage Alice Jane , Heys Michelle , Lut Irina , Hardelid Pia 
Published: May 2021

IntroductionMigration status is a key determinant of health, but health outcomes among migrant children and young people (CYP), that is, those aged under 18 years, are poorly understood. A ‘healthy migrant’ effect has been demonstrated among adults, but evidence for the same effect in CYP is lacking. No large studies or reviews exist reporting comprehensive or holistic health outcomes among migrant CYP. We aim to identify and synthesise original quantitative research on health of migrant CYP to explore the relations between migration status and health outcomes.Methods and analysisA search of PubMed/Medline, Embase, Cochrane and grey literature sites will be undertaken for any original quantitative research on health outcomes of migrant CYP from 01 January 2000 onwards. Outcomes addressed: mortality, communicable diseases, non-communicable diseases, nutritional status, mental health, disability, vaccine coverage, and accidental and non-accidental injuries (including assault and abuse). Search results will be screened and presented in a Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram.The Newcastle–Ottawa Scale assessment tool will be used to assess study quality. If feasible, depending on study availability data heterogeneity (explored using I2statistic), results will be pooled for meta-analysis. If sufficient data are available, a priori defined subgroup analyses will be undertaken. A narrative quantitative synthesis will be presented, taking account of study quality and assessed risk of bias.The anticipated search completion date is 01 June 2021 with write-up completed by 01 April 2022.Ethics and disseminationFormal ethical approval will not be sought as we will be accessing data already in the public domain. This review will be submitted for publication in a high-impact journal and presented at international conferences. The results of this work will be shared with groups of migrant children as part of an ongoing engagement project.PROSPERO registration numberCRD42020166305.
Living with Dementia in Aotearoa (LiDiA): a cross-sectional feasibility study protocol for a multiethnic dementia prevalence study in Aotearoa/New Zealand
Authors: Martinez-Ruiz Adrian , Yates Susan , Cheung Gary , Dudley Makarena , Krishnamurthi Rita , Fa’alau Fuafiva , Roberts Mary , Taufa Seini , Fa’alili-Fidow Jacinta , Rivera-Rodriguez Claudia , Kautoke Staverton , Ma’u Etuini , Kerse Ngaire , Cullum Sarah 
Published: May 2021

IntroductionAotearoa/New Zealand (NZ) is officially recognised as a bicultural country composed of Māori and non-Māori. Recent estimations have projected a threefold increase in dementia prevalence in NZ by 2050, with the greatest increase in non-NZ–Europeans. The NZ government will need to develop policies and plan services to meet the demands of the rapid rise in dementia cases. However, to date, there are no national data on dementia prevalence and overseas data are used to estimate the NZ dementia statistics. The overall aim of the Living with Dementia in Aotearoa study was to prepare the groundwork for a large full-scale NZ dementia prevalence study.Methods and analysisThe study has two phases. In phase I, we will adapt and translate the 10/66 dementia assessment protocol to be administered in Māori, Samoan, Tongan and Fijian–Indian elders. The diagnostic accuracy of the adapted 10/66 protocol will be tested in older people from these ethnic backgrounds who were assessed for dementia at a local memory service. In phase II, we will address the feasibility issues of conducting a population-based prevalence study by applying the adapted 10/66 protocol in South Auckland and will include NZ–European, Māori, Samoan, Tongan, Chinese and Fijian–Indian participants. The feasibility issues to be explored are as follows: (1) how do we sample to ensure we get accurate community representation? (2) how do we prepare a workforce to conduct the fieldwork and develop quality control? (3) how do we raise awareness of the study in the community to maximise recruitment? (4) how do we conduct door knocking to maximise recruitment? (5) how do we retain those we have recruited to remain in the study? (6) what is the acceptability of study recruitment and the 10/66 assessment process in different ethnic groups?Ethics and disseminationThe validity and feasibility studies were approved by the New Zealand Northern A Health and Disability Ethics Committee (numbers 17NTA234 and 18NTA176, respectively). The findings will be disseminated through peer-reviewed academic journals, national and international conferences, and public events. Data will be available on reasonable request from the corresponding author.
Aquablation versus holmium laser enucleation of the prostate in the treatment of benign prostatic hyperplasia in medium-to-large-sized prostates (ATHLETE): protocol of a prospective randomised trial
Authors: Müllhaupt Gautier , Güsewell Sabine , Schmid Hans-Peter , Zumstein Valentin , Betschart Patrick , Engeler Daniel S , Abt Dominik 
Published: May 2021

IntroductionA novel method for the surgical treatment of benign prostatic hyperplasia (BPH) called Aquablation has become commercially available. Previous studies have been able to show similar functional results when compared with transurethral resection of the prostate and a high efficacy has been demonstrated when this approach is applied to patients with a prostate size of 80–150 cm3.Holmium laser enucleation of the prostate (HoLEP) is a well-established procedure in the surgical treatment of BPH in prostate glands larger than 30 mL and a first-line therapy in glands over 80 mL. To date, no data are available whether Aquablation is non-inferior compared with HoLEP in the treatment of patients with medium-to-large-sized prostates regarding safety and efficacy.Methods and analysisThis is a prospective, randomised, open-label, non-inferiority clinical trial conducted at a Swiss centre of tertiary care. The primary outcome is assessment of non-inferiority of Aquablation compared with HoLEP in reducing lower urinary tract symptoms due to benign prostatic obstruction measured by the International Prostate Symptom Score (IPSS). Randomisation will be performed using secuTrial, stratifying on age (<70 years, 70+ years) and prostate volume (<100 mL, 100+ mL). Both interventions are performed in an inpatient setting and regular follow-up controls starting 8 weeks after intervention and continuing up to 5 years will be performed. The primary outcome (change in IPSS from baseline to 6 months) will be tested for non-inferiority with a one-sided t-test. Secondary outcomes, such as efficacy parameters, several patient-reported outcome measures, and periprocedural and safety parameters will be described by calculating means or relative frequencies for each treatment group and testing differences with two-sided standard superiority tests.Ethics and disseminationThe study was approved by the local ethics committee (EKOS 2020-02353). Results of the primary endpoint and each of the secondary endpoints will be published in an international peer-reviewed journal.Trial registration numberClinicalTrials.gov Registry (NCT04560907).
Risk of asthma in children diagnosed with bronchiolitis during infancy: protocol of a longitudinal cohort study linking emergency department-based clinical data to provincial health administrative databases
Authors: Abdullah Kawsari , Fell Deshayne B , Radhakrishnan Dhenuka , Hawken Steven , Johnson David W , Mandhane Piush , To Teresa , Joubert Gary , Plint Amy C 
Published: May 2021

IntroductionThe Canadian Bronchiolitis Epinephrine Steroid Trial (CanBEST) and the Bronchiolitis Severity Cohort (BSC) study enrolled infants with bronchiolitis during the first year of life. The CanBEST trial suggested that treatment of infants with a combined therapy of high-dose corticosteroids and nebulised epinephrine reduced the risk of admission to hospital. Our study aims to—(1) quantify the risk of developing asthma by age 5 and 10 years in children treated with high-dose corticosteroid and epinephrine for bronchiolitis during infancy, (2) identify risk factors associated with development of asthma in children with bronchiolitis during infancy, (3) develop asthma prediction models for children diagnosed with bronchiolitis during infancy.Methods and analysisWe propose a longitudinal cohort study in which we will link data from the CanBEST (ISRCTN56745572, post-results) and BSC study with routinely collected data from provincial health administrative databases. Our outcome is asthma incidence measured using a validated health administrative data algorithm. Primary exposure will be treatment with a combined therapy of high-dose corticosteroids and nebulised epinephrine for bronchiolitis. Covariates will include type of viral pathogen, disease severity, medication use, maternal, prenatal, postnatal and demographic factors and variables related to health service utilisation for acute lower respiratory tract infection. The risk associated with development of asthma in children treated with high-dose corticosteroid and epinephrine for bronchiolitis will be assessed using multivariable Cox proportional hazards regression models. Prediction models will be developed using multivariable logistic regression analysis and internally validated using a bootstrap approach.Ethics and disseminationOur study has been approved by the ethics board of all four participating sites of the CanBEST and BSC study. Finding of the study will be disseminated to the academic community and relevant stakeholders through conferences and peer-reviewed publications.
Development of a short-form Swedish version of the Montreal Cognitive Assessment (s-MoCA-SWE): protocol for a cross-sectional study
Authors: Abzhandadze Tamar , Lundström Erik , Buvarp Dongni , Eriksson Marie , Quinn Terence J , S Sunnerhagen Katharina 
Published: May 2021

IntroductionShort forms of the Montreal Cognitive Assessment (MoCA) have allowed quick cognitive screening. However, none of the available short forms has been created or validated in a Swedish sample of patients with stroke.The aim is to develop a short-form Swedish version of the MoCA (s-MoCA-SWE) in a sample of patients with acute and subacute stroke. The specific objectives are: (1) to identify a subgroup of MoCA items that have the potential to form the s-MoCA-SWE; (2) to determine the optimal cut-off value of s-MoCA-SWE for predicting cognitive impairment and (3) and to compare the psychometric properties of s-MoCA-SWE with those of previously developed MoCA short forms.Methods and analysisThis is a statistical analysis protocol for a cross-sectional study. The study sample will comprise patients from Väststroke, a local stroke registry from Gothenburg, Sweden and Efficacy oF Fluoxetine—a randomisEd Controlled Trial in Stroke (EFFECTS), a randomised controlled trial in Sweden. The s-MoCA-SWE will be developed by using exploratory factor analysis and the boosted regression tree algorithm. The cut-off value of s-MoCA-SWE for impaired cognition will be determined based on binary logistic regression analysis. The psychometric properties of s-MoCA-SWE will be compared with those of other MoCA short forms by using cross-tabulation and area under the receiving operating characteristic curve analyses.Ethics and disseminationThe Väststroke study has received ethical approval from the Regional Ethical Review Board in Gothenburg (346–16) and the Swedish Ethical Review Authority (amendment 2019–04299). The handling of data generated within the framework of quality registers does not require written informed consent from patients. The EFFECTS study has received ethical approval from the Stockholm Ethics Committee (2013/1265-31/2 on 30 September 2013). All participants provided written consent. Results will be published in an international, peer-reviewed journal, presented at conferences and communicated to clinical practitioners in local meetings and seminars.
Fatigue in newly diagnosed acute myeloid leukaemia: general population comparison and predictive factors
Authors: Oswald Laura B , Venditti Adriano , Cella David , Cottone Francesco , Candoni Anna , Melillo Lorella , Cairoli Roberto , Storti Gabriella , Salutari Prassede , Luppi Mario , Albano Francesco , Martelli Maria Paola , Cuneo Antonio , Tafuri Agostino , Trisolini Silvia Maria , Tieghi Alessia , Fazi Paola , Vignetti Marco , Efficace Fabio 
Published: May 2021

ObjectivesThis study compared the burden of fatigue between treatment-naïve patients with newly diagnosed acute myeloid leukaemia (AML) and the general population and investigated patient factors associated with fatigue severity.MethodsPretreatment patient-reported fatigue was assessed with the Functional Assessment of Chronic Illness Therapy-Fatigue questionnaire in a sample of 463 newly diagnosed patients with AML who were enrolled in a clinical trial. Multivariable linear regression models were used to estimate the adjusted mean differences in fatigue between patients with AML and adults from the general population (n=847) by AML disease risk categories. A clinically meaningful difference in fatigue was defined as ≥3 points. Univariable and multivariable linear regression models were used to identify sociodemographic, clinical and molecular correlates of worse fatigue in patients with AML.ResultsPatients with AML reported adjusted mean fatigue scores that were 7.5 points worse than the general population (95% CI −8.6 to −6.4, p<0.001). Across AML disease risk categories, adjusted mean differences in fatigue compared with the general population ranged from 6.7 points worse (patients with favourable risk: 95% CI −8.6 to −4.8, p<0.001) to 8.9 points worse (patients with poor risk, 95% CI −10.5 to −7.2, p<0.001). Overall, 91% of patients with AML reported fatigue that was equal to or worse than the general population’s median fatigue score. Higher pretreatment fatigue was independently associated with female sex, WHO performance status ≥1 and lower platelet levels.ConclusionsPatients with newly diagnosed AML reported worse fatigue than the general population, and mean differences exceeded twice the threshold for clinical significance. Our findings may help to identify patients with AML most likely to benefit from supportive care interventions to reduce fatigue.
Non-curative surgical oncology: postoperative needs and preferences
Authors: Seibæk Lene , Thaysen Henriette Vind , Lomborg Kirsten Elisabeth 
Published: May 2021

ObjectiveWhen intended curative cancer surgery is not completed, the postoperative transition to palliative care represents a prognostic landmark to patients and their families. In patients referred for highly specialised surgery for peritoneal metastases from the intestinal tract and ovaries, surgery is not performed in approximately 25%. Still, little is known of their postoperative needs and preferences.MethodsWe performed 14 qualitative research interviews with 12 patients (four men and eight women, aged 41–85 years) undergoing surgery for peritoneal metastases; five of these were together with a relative. Five of the participants had ovarian, and seven had colorectal cancer (four men and seven women). The interviews followed a semistructured interview guide, were audio recorded, transcribed verbatim and analysed using meaning condensation.ResultsPatients accepted the surgeon’s decision of refraining from the intended surgery. During the postoperative period, when realising the prognostic consequences, their needs changed rapidly, in some cases from day to day, and gradually they developed a reoriented focus on their lives. The findings were framed by two themes dealing with ‘Change in treatment strategy’ and ‘Physical and psychosocial aspects of not undergoing curative surgery’.ConclusionWhen curative cancer surgery is not completed as intended, patient-centred communication is essential for patients’ psychosocial reorientation and quality of life. Further, to support their well-being and action competences, patients have a need for basic supportive care and physical restitution. Finally, high-quality postoperative palliative care needs to be coordinated, which requires staff training and reorganisation of pathways.
Characterizing key agents in the cryptocurrency economy through blockchain transaction analysis
Authors: Liu Xiao Fan , Ren Huan-Huan , Liu Si-Hao , Jiang Xian-Jian 
Published: May 2021

AbstractThe cryptocurrency economy provides a comprehensive digital trace of human economic behavior: almost all cryptocurrency users’ activities are faithfully recorded in transactions on public blockchains. However, the user identifiers in the transaction records, i.e., blockchain addresses, are anonymous. That is, they cannot be associated with any real “off-chain” identify of actual users. Nonetheless, identifying the economic roles of the addresses from their past behaviors is still feasible. This paper analyzes Ethereum token transactions, characterizes key economic agents’ behavior from their transaction patterns, and explores their identifiability through interpretable machine learning models. Specifically, six types of most active economic agents are considered, including centralized cryptocurrency exchanges, decentralized exchanges, cryptocurrency wallets, token issuers, airdrop services, and gaming services. Transaction patterns such as trading volume, transaction tempo, and structural properties of transaction networks are defined for individual blockchain addresses. The results showed that cryptocurrency exchanges and online wallets have signature behavior patterns and hence can be accurately distinguished from other agents. Token issuers, airdrop services, and gaming services can sometimes be confused. Moreover, transaction networks’ features provide the richest information in the economic agent’s identification.
Cytogenetic bio-dosimetry techniques in the detection of dicentric chromosomes induced by ionizing radiation: A review
Authors: Ludovici G. M. , Cascone M. G. , Huber T. , Chierici A. , Gaudio P. , de Souza S. O. , d’Errico F. , Malizia A. 
Published: May 2021

AbstractIonizing radiation is ubiquitous in the environment. Its source can be natural, such as radioactive materials present in soil and cosmic rays, or artificial, such as the fuel for nuclear power plants. Overexposure to ionizing radiation may damage living tissue and could cause severe health problems (i.e., mutations, radiation sickness, cancer, and death). Cytogenetic bio-dosimetry has the great advantage to take into account the inter-individual variation, and it is informative even when physical dosimetry is not applicable; moreover, it is the definitive method to assess exposure to ionizing radiation recommended by the World Health Organization (WHO). Such a procedure involves counting the frequency of dicentric chromosomes (DCs), which are the most studied chromosomal aberrations used as absorbed radiation biomarkers, during the metaphase of cells. A set of algorithms, tested on different programming languages to automatically identify DCs, is analyzed by the authors together with an Automated Dicentric Chromosome Identifying software (ADCI) mostly based on OpenCV programming libraries. The purpose of this work is to review the main results regarding the correlation between ionizing radiation and dicentric chromosomes in cytogenetic bio-dosimetry.