bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consumed Landscapes: Coal, Air and Circulation in the Writings of Catherine Hutton
Authors: Constantine Mary-Ann 
Published: June 2021

This essay examines a particular nexus of ideas about health and circulation in relation to the practice and the literature of travel and tourism in Romantic-period Britain. Wales, like other ‘picturesque’ destinations, is often envisaged in these writings, and in fiction, as a space of non-metropolitan purity, of clean air, and of health. Yet this is precisely the period of industrial expansion in both south and north Wales, and coal-mines, copper-works, iron foundries and smelting furnaces also figured on many tourist itineraries. Taking as its entry point the novels of Birmingham-based writer Catherine Hutton – particularly The Welsh Mountaineer (1817), which was informed by the author's own experience of travel in north Wales in the late 1790s – the essay sets the familiar trope of travel for a ‘change of air’ against the literal changes to air quality which resulted from Britain's rapid industrialisation in the decades around 1800, revealing some inventive and complex adaptations of contemporary ideas about the effects of ‘pure’ and ‘polluted’ air on human health.
Atezolizumab Monotherapy or Plus Chemotherapy in First-Line Treatment for Advanced Non-Small Cell Lung Cancer Patients: A Meta-Analysis
Authors: Li Dan-Ni , Lu Wen-Qing , Yang Bo-Wen , Zhang Ling-Yun , Jin Bo , Wang Shuo , Che Xiao-Fang , Li Ce , Liu Yun-Peng , Qu Xiu-Juan 
Published: June 2021

BackgroundAtezolizumab plus chemotherapy has been recommended as a first-line treatment option for patients with advanced non-small cell lung carcinoma (NSCLC) irrespective of programmed cell death-ligand 1 (PD-L1) expression. Currently, little is known about the efficacy and treatment-related adverse effects (TRAEs) of subtracting chemotherapy from the combination for patients with high PD-L1 expression. Thus, we performed an indirect comparison between atezolizumab plus chemotherapy and atezolizumab alone.MethodsA total of five eligible randomized controlled trials (RCTs) were identified from PubMed, EMBASE, and Cochrane Central controlled trial registries, using keywords including atezolizumab, PD-1, PD-L1, NSCLC, and RCT. The clinical outcomes of objective response rate (ORR), progression-free survival (PFS), OS, and TRAEs were extracted and evaluated. Using indirect analysis, the efficacy and TRAEs were compared between arm A (atezolizumab plus chemotherapy) and arm C (atezolizumab), linked by arm B (chemotherapy).ResultsDirect comparison revealed that both atezolizumab plus chemotherapy (HR 0.65, P = 0.003) and atezolizumab alone (HR 0.59, P = 0.010) significantly improved OS compared with chemotherapy. More importantly, the indirect comparison showed that atezolizumab plus chemotherapy was not superior to atezolizumab regarding OS (RR 1.10, P =0.695) and ORR (RR 1.11, P = 0.645). However, patients who received atezolizumab combined with chemotherapy experienced more ≥ grade 3 TRAEs (RR 4.23, P&lt;0.001) and TRAEs leading to drug discontinuation (RR 3.60, P&lt;0.001) than those treated with atezolizumab monotherapy.ConclusionsAtezolizumab monotherapy might be a better treatment option for patients with advanced NSCLC and high PD-L1 expression than atezolizumab plus chemotherapy.
Markers of Prognosis for Early Stage Cervical Cancer Patients (Stage IB1, IB2) Undergoing Surgical Treatment
Authors: Xu Chen , Ma Tie , Sun Hongzan , Li Xiaohan , Gao Song 
Published: June 2021

BackgroundFor individuals with cervical cancer, large tumor volume, lymph node metastasis, distant metastasis, and parauterine infiltration are usually associated with a poor prognosis. Individuals with stage 1B1 and 1B2 cervical cancer usually do not have these unfavorable prognostic factors. Once the disease progresses, the prognosis becomes extremely poor. Therefore, investigating the prognostic markers of these cervical cancer patients is necessary for treatment.MethodsThis retrospective study included 95 cervical cancer patients treated with surgery. The patients were divided into progressor and non-progressor groups according to postoperative follow-up results. T-test (or Mann−Whitney U test), chi-squared test (or Fisher’s exact test) and receiver operating characteristic (ROC) curves were used to evaluate imaging, hematology, and clinicopathological index differences between the two groups. Cox analysis was performed to select the independent markers of progression-free survival (PFS) when developing the nomogram. Validation of the nomogram was performed with 1000 bootstrapped samples. The performance of the nomogram was validated with ROC curves, generated calibration curves, and Kaplan-Meier and decision curve analysis (DCA).ResultsCervical stromal invasion depth, lymphovascular space invasion (LVSI), human papilloma virus (HPV-16), Glut1, D-dimer, SUVmax and SUVpeak showed significant differences between the two groups. Multivariate Cox proportional hazard model showed SUVpeak (p = 0.012), and HPV-16 (p = 0.007) were independent risk factors and were used to develop the nomogram for predicting PFS. The ROC curves, Kaplan-Meier method, calibration curves and DCA indicated satisfactory accuracy, agreement, and clinical usefulness, respectively.ConclusionsSUVpeak level (≥7.63 g/cm3) and HPV-16 negative status before surgery were associated with worse PFS for patients with cervical cancer. Based on this result, we constructed the nomogram and showed satisfactory performance. Clinically, individualized clinical decision-making can be performed on patients based on this result.
Petroleum and Chlorinated Solvents in Meconium and the Risk of Hypospadias: A Pilot Study
Authors: Rouget Florence , Bihannic Adèle , Cordier Sylvaine , Multigner Luc , Meyer-Monath Marie , Mercier Fabien , Pladys Patrick , Garlantezec Ronan 
Published: June 2021

Background: Hypospadias is a male congenital malformation that occurs in ~2 of 1,000 births. The association between hypospadias and fetal exposure to environmental chemicals has been studied, but the results are inconsistent. Although several petroleum and chlorinated solvents are suspected to have teratogenic effects, their role in the occurrence of hypospadias has been little studied and never using biomarkers of exposure. We aimed to evaluate the association between fetal exposure to petroleum and chlorinated solvents measured in meconium and the occurrence of hypospadias.Methods: We conducted a pilot case-control study in the maternity of the University Hospital of Rennes (France). Eleven cases of hypospadias and 46 controls were recruited between October 2012 and January 2014. Data from hospital records and maternal self-reported questionnaires, including socio-demographic characteristics and occupational and non-occupational exposure to chemicals, were collected. Meconium samples were collected using a standardized protocol. Levels of petroleum solvents (toluene, benzene, ethylbenzene, and p, m, and o xylene), certain metabolites (mandelic acid, hippuric acid, methylhippuric acid, S-phenylmercapturic acid, S-benzylmercapturic acid, and phenylglyoxylic acid), and two chlorinated solvents (trichloroethylene and tetrachloroethylene) were measured in meconium by gas and liquid chromatography, both coupled to tandem mass spectrometry. Associations between the concentration of each chemical and the occurrence of hypospadias were analyzed using exact logistic regressions adjusted for maternal age, educational level, pre-pregnancy body mass index, and alcohol, and tobacco consumption during pregnancy. Results are presented with odds ratios (ORs) and their 95% confidence intervals (CIs).Results: Quantification rates for petroleum and chlorinated solvents or metabolites ranged from 2.2% (for methylhippuric acid) to 77.1% (for trichloroethylene) of the meconium samples. We found a significant association between the quantification of phenylglyoxylic acid (metabolite of styrene and ethylbenzene) in the meconium and a higher risk of hypospadias (OR = 14.2, 95% CI [2.5–138.7]). The risk of hypospadias was non-significantly elevated for most of the other solvents and metabolites.Conclusion: This exploratory study, on a limited number of cases, suggests an association between petroleum solvents and hypospadias. Additional studies are needed to confirm these results and identify the determinants for the presence of these solvents in meconium.
“Will It Affect Our Chances of Having Children?” and Feeling “Like a Ticking Bomb” —The Fertility Concerns and Fears of Cancer Progression and Recurrence in Cancer Treatment Decision-Making Among Young Women Diagnosed With Gynaecological or Breast Cancer
Authors: Sobota Aleksandra , Ozakinci Gozde 
Published: June 2021

Objective: Cancer treatment decision making process is particularly fraught with challenges for young women because the treatment can affect their reproductive potential. Among many factors affecting the process, fears of cancer progression and recurrence can also be important psychological factors. Our aim is to apply Common-Sense Model and shared decision-making model to explore experiences of treatment decision-making women of reproductive age who were diagnosed with gynaecological or breast cancer and the influence of fertility issues and fears of cancer progression and recurrence.Method: We conducted telephone interviews with 24 women who were diagnosed with gynaecological or breast cancer aged 18–45, who finished active treatment within 5 years prior to study enrolment and had no known evidence of cancer recurrence at the time of participation. They were recruited from three NHS oncology clinics in Scotland and online outlets of cancer charities and support organisations. We analysed the data using Braun and Clarke's thematic analysis method as it allows for both inductive and deductive analyses.Results: We identified five main themes pertaining to treatment-related decision-making experiences and fertility issues and fear of progression and recurrence: Becoming aware of infertility as a potential consequence of cancer treatment; Balancing-prioritising cancer and fertility; Decisions about treatments; Evaluation of treatment decisions; and The consequences of treatments. Sub-themes have also been reported. Different factors such as whether the cancer is breast or gynaecological, physicians' willingness of discussing fertility, influence of others in decision-making, childbearing and relationship status as well as fear of cancer recurrence emerged as important.Conclusion: The importance of physicians directly addressing fertility preservation in the process of treatment decision-making and not treating it as an “add-on” was evident. Satisfaction with treatment decisions depended on both the quality of the process of decision making and its outcome. Fear of recurrence was present in different parts of the adaptation process from illness perceptions to post-treatment evaluation of decisions. Both Common-Sense Model and shared decision-making model were helpful in understanding and explaining young women's experience of treatment decision-making and fertility concerns.
FEATURES OF CONDUCTING FIELD RESEARCH AT THE OBJECTS OF THE ROAD NETWORK AND LABORATORY STUDIES OF ROAD SURFACE SAMPLES DURING THE FORENSIC CONSTRUCTION AND TECHNICAL EXAMINATION AND FORENSIC EXAMINATION OF MATERIALS, SUBSTANCES AND PRODUCTS
Authors: Posilskyi O. , Savenok O. , Chaliuk I. , Burlaka І. 
Published: June 2021

According to the requirements of regulatory documentation, there are a large number of indicators measured for asphalt concrete. Modern expert practice shows that the forensic examination of asphalt concrete although relies on the research methods specified in GOST (National Standards of Ukraine), but requires its optimization.
Carrying out field research at the objects of the road network, regulates the methodology, sequence and rules for measuring and taking samples of the road surface for laboratory tests.
The main stages of research at the objects of the road network:
I.	Preparation for field research.
II.	Identification of the object on the ground.
III.	Inspection of the object of study in order to establish the characteristics and boundaries of the work.
IV.	Fixation (photo-video shooting, topography) of the performed works.
V.	Carrying out measurements of the volume of completed construction work.
VI.	Sampling.
VII.	Recording the results of research.
VIII.	Conducting laboratory tests.
In turn, laboratory tests have the following main stages:
I.	Photo of packaging, photo of samples (center marks or cuttings).
II.	Numbering (marking) of research objects.
III.	Measuring the thickness of the center marks layers.
IV.	Mechanical separation of center marks or cuttings into layers.
V.	Washing objects and drying it to constant weight.
VI.	Determination of the average density of asphalt concrete.
VII.	Determination of water saturation.
VIII.	Making a pooled sample.
IX.	Determining the amount of astringent.
X.	Determination of the grain composition of the mineral part of the mixture.
XI.	Determination of the actual density of the mixture by pycnometric method (for RMACM).
XII.	Determination of residual porosity (for RMACM).
XIII.	Reshaping of samples (for HACM).
XIV.	Determination of the average density of reshaped samples.
XV.	Determination of water saturation of reshaped samples.
XVI.	Determination of compaction coefficient.
XVII.	Determination of compressive strength.
The expert practice of the authors in this article made it possible to transform the stages of forensic examination of asphalt pavements so that the effectiveness of such examination has increased.
The proposed methodology, sequence and rules of field research on the objects of the road network in terms of sampling of pavement and subsequent laboratory tests of these samples, enable experts to provide a qualitative and objective conclusion.
Perancangan Sistem Informasi Akuntansi Persediaan Barang Dagang Menggunakan SAK EMKM Berbasis Web
Authors: Yulianto Hery Dwi , Maulana Dyan Fachri 
Published: June 2021

Tujuan dari penelitian ini adalah membuat suatu perancangan sistem informasi akuntansi persediaan barang dagangan pada Toko Cireng Cinta dengan berbasis website dan SAK EMKM, dimana diharapkan dengan dibangunnya sistem tersebut dapat memberikan gambaran aplikasi sistem informasi akuntansi persediaan barang dagang yang tepat. Saat ini Toko Cireng Cinta masih menggunakan pengolahan keseluruhsan secara manual, dimana saat melakukan pemesanan produk harus mendatangi tempat penjual untuk melakukan pemesanan atau melalui via SMS atau WA, setelah itu saat pengambilan tidak diberi bukti pembayaran yang seharusnya itu bisa menjadi bukti untuk nanti pembuatan laporan. Pengelolaan persediaan pun masih secara manual dan belum menggunakan standar akuntansi yang ada. Maka dari itu dengan dibuatkannya perancangan sistem informasi akuntansi persediaan barang dagangan ini untuk memudahkan pengembangan aplikasi sesuai dengan SAK EMKM dan kegiatan perusahaan. Medode yang digunakan dalam penelitian ini adalah metode deskriptif dan juga survey, dimana dengan melakukan survey langsung pada tempat kegiatan memudahkan untuk melihat langsung kekurangan dan potensi yang mungkin dapat dikembangan lebih lanjut. Unit analisis yang diteliti dalam penelitian ini adalah Toko Cireng Cinta, populasi yang diteliti adalah laporan persediaan dari mulai Januari-April 2020. Hasil dari penelitian ini diharapkan bisa mengetahui tentang sistem informasi persediaan barang dagang, juga membuat perancangan sistem yang akan diterapkan pada perusahaan. Proses perancangan dari pembuatan ERD, Diagram Konteks, Struktur menu program, kode akun, jurnal umum, dan kartu persediaan barang dagangan diperlukan oleh perusahaan. Dengan terbangunnya sistem ini akan memudahkan proses integrasi permasalahan perusahaan dengan perancangan aplikasi kedepannya.
VỀ TÍNH DUY NHẤT CỦA CÁC HÀM PHÂN HÌNH CHIA SẺ MỘT PHẦN CÁC GIÁ TRỊ CÙNG VỚI CÁC HÀM DỊCH CHUYỂN CỦA CHÚNG
Authors: Nam Nguyễn Hải , Nguyệt Nguyễn Minh , Ngọc Nguyễn Thị , Thủy Vũ Thị 
Published: June 2021

Năm 1926, R. Nevanlinna chỉ ra rằng hai hàm phân hình khác hằng và trên mặt phẳng phức chia sẻ năm giá trị khác nhau IM thì trên toàn bộ ­­­ Nếu một hàm phân hìnhcó siêu bậc nhỏ hơn 1 và hàm dịch chuyển của nó chia sẻ bốn giá trị phân biệt hoặc chia sẻ bốn hàm nhỏ tuần hoàn trong mặt phẳng phức, thì liệu với mọi hay không? Mục đích của chúng tôi là nghiên cứu tính duy nhất của những hàm phân hình trong tình huống như thế. Để đạt được mục đích, chúng tôi sử dụng kĩ thuật trong lí thuyết Nevanlinna bằng cách dựa vào ước lượng các hàm đếm và sử dụng tích chất của tổng số khuyết của các giá trị trong mặt phẳng phức. Xét bốn hàm nhỏ tuần hoàn với chu kì c trong mặt phẳng phức với Chúng tôi chứng minh được kết quả như sau: Giả sử rằng hàm phân hình có siêu bậc nhỏ hơn 1 cùng với hàm dịch chuyển của nó chia sẻ CM, chia sẻ một phần , đồng thời số khuyết thu gọn của tại là cực đại. Thế thì dưới điều kiện về số khuyết tại một giá trị bất kì khác , ta có với mọi Kết quả của chúng tôi là sự tiếp tục các công việc trước đó của các tác giả và nó cung cấp cho chúng ta có thêm hiểu biết về những hàm phân hình có siêu bậc nhỏ hơn 1.
HỆ THỐNG LỌC BỤI MỊN THÔNG MINH
Authors: Hằng Vũ Thúy 
Published: June 2021

Trong bài báo này, tác giả tập trung xây dựng một hệ thống lọc bụi mịn thông minh áp dụng vào đời sống nhằm làm sạch không khí, giảm thiểu những tác hại mà ô nhiễm không khí, đặc biệt là ô nhiễm do bụi mịn gây ra. Kết quả qua các trường hợp thực nghiệm, khảo sát cho thấy hệ thống đã tự động cập nhật được giá trị nồng độ bụi mịn PM (Particulate Matter) là PM2,5 (kích thước đường kính nhỏ hơn hoặc bằng 2,5 micromet) và PM10 (kích thước đường kính nhỏ hơn hoặc bằng 10 micromet). Dựa vào đó, nếu nồng độ bụi mịn vượt ngưỡng cho phép thì chức năng lọc không khí được kích hoạt: Tăng tốc độ quạt hút gió để tăng lưu lượng không khí đi qua hệ thống; Bộ phận tạo hơi nước được bật để làm ẩm không khí và tăng kích thước bụi, giúp việc lọc không khí qua màng lọc than hoạt tính và màng lọc heppa được hiệu quả tối đa. Ngoài ra, tác giả còn xây dựng ứng dụng trên hệ điều hành Android với tên ICTUAir có khả năng hiển thị thông tin về chỉ số bụi mịn trong không khí tại các điểm đặt hệ thống dưới dạng bản đồ Google maps. Website bản đồ GIS có khả năng cập nhật thông tin về mức độ ô nhiễm không khí dựa trên dữ liệu được gửi lên tự động từ vị trí đặt hệ thống.
MEMADUKAN INOVASI DAN KEARIFAN LOKAL DALAM PENGAJARAN LITERASI PADA ANAK USIA DINI: PENDAMPINGAN GERAKAN LITERASI
Authors: Kurniawati Nia , Adawiyah Aprilla , Munsi Mia Fatimatul 
Published: June 2021

ABSTRAK Literasi dini dipandang sebagai fondasi yang sangat penting dalam perkembangan kognitif manusia, dalam pengajaran literasi Pada Anak Usia Dini (PAUD), perlu diperhatikan bahan, media, dan cara penyampaian agar anak usia dini mudah untuk memahami dan menanamkan nilai-nilai kehidupan yang terdapat dalam pembelajaran, yang dituntut untuk dapat berinovasi dan kreatif dalam menyampaikan bahan pembelajaran literasi, dalam tumbuh kembang dan karakter anak usia dini. Kegiatan ini bertujuan untuk memberikan pendampingan pada guru-guru PAUD di desa Sukawangi, Warungkondang. Adapun metode kegiatan ini dilaksanakan pelatihan tentang teknik pengajaran literasi dini untuk anak-anak PAUD. Teknik yang digunakan pada para guru adalah mendongeng dengan menggunakan media boneka jari dan buku besar. Pengabdian ini bertujuan membuat guru menjadi kreatif dan anak usia dini lebih aktif terlibat pembelajaran serta mengenal kearifan lokal Cianjur. ABSTRACTEarly literacy is seen as a very important foundation in human cognitive development, in teaching literacy in PAUD, it is necessary to pay attention to materials, media, and delivery methods so that early childhood is easy to understand and instill the values of life contained in learning, which is required to be able to innovate and be creative in delivering literacy learning materials, in the development and character of early childhood. This activity aims to provide assistance to PAUD teachers in Sukawangi village, Warungkondang. The method of this activity is training on early literacy teaching techniques for PAUD children. The technique used by the teachers is storytelling using finger puppets and large books. This service aims to make teachers creative and early childhood more actively involved in learning and get to know Cianjur local wisdom.
КОРЕКЦІЯ КОМПЛЕКСАМИ АНТИГИПО-КСАНТІВ І АНТИОКСИДАНТІВ СТАНУ УБОЩЕЛЕПНОЇ СИСТЕМИ І ТКАНИН РО-ТОВОЇ ПОРОЖНИНИ ЩУРІВ В УМОВАХ ДІЇ ГІПОКСІЇ ТА КАРИЕСОГЕННОГО РА-ЦІОНУ
Authors: Іванов В.С. , Шнайдер С.А. , Деньга О.В. , Ткаченко Є.К. 
Published: June 2021

Мета – вивчення впливу комплексу дієтичних доба-вок, що містять бурштинову кислоту і гліцин, на стан зубощелепної системи і тканини ротової поро-жнини щурів в умовах дії внутрішньоутробної гіпок-сії і карієсогенного раціону.
Матеріали та методи. Об'єктами дослідження були 57 білих щурів лінії Вістар. У 4-х групах у щурів-самок протягом 10 днів вагітності відтворювали тканинну гіпоксію. Після народження щурят в 1-міс віці са-джали на карієсогенний раціон. У продовженні 30 днів щури на фоні отриманих експериментальних впливів отримували per os розчини суміші комплексів дієтичних добавок «Бурштинова кислота» і «Гліцин».Висновки. Результати проведених досліджень щодо впливу сумісної дії бурштинової кислоти і гліцину в умовах відтворення гіпоксії і утримання потомства від цих щурів на карієсогенному раціоні продемонст-рували значну карієс-профілактичну і пародонто-протекторну дію.