bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epigenetic regulator UHRF1 suppressively orchestrates multiple pathogenesis in rheumatoid arthritis.
Authors: Imai Yuuki , Saeki Noritaka , Inoue Kazuki , Ideta-Otsuka Maky , Watamori Kunihiko , Mizuki Shinichi , Takenaka Katsuto , Igarashi Katsuhide , Miura Hiromasa 
Published: March 2021

Abstract
Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation with aberrant epigenetic alterations, eventually leading to joint destruction. However, epigenetic regulatory mechanisms underlying RA pathogenesis remain largely unknown. Here, we showed that Ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) , a key molecule involved in maintenance of DNA methylation during cell division, is a central epigenetic regulator that orchestrates the suppression of expression of multiple factors that exacerbate RA. We found that murine arthritis tissue and human RA tissue, particularly synovial fibroblasts (SF), exhibit remarkable up-regulation of expression of Uhrf1. SF-specific Uhrf1 conditional knockout mice showed more severe arthritic phenotypes and apoptosis-resistant SF. Integrative analysis of the transcriptome and methylome showed that expression of several cytokines including Ccl20 was up-regulated in Uhrf1-deficient SF. In RA patients, disease activity scores, CCL20 expression, Th17 accumulation and apoptosis resistance were negatively correlated with UHRF1 expression in synovium. Finally, stabilization of UHRF1 by Ryuvidine administration diminished disease pathogenesis in arthritis model mice. Our results demonstrated that UHRF1 expressed in SF can contribute to suppression of multiple pathogenic events associated with RA such as Th17 recruitment, SF apoptosis and bone destruction, suggesting that targeting UHRF1 could represent a novel therapeutic strategy for RA.
Effectiveness of a Lockdown Policy During a Global Pandemic
Authors: Shih Yung Chin 
Published: March 2021

Background:
In 2020, when the World Health Organization (WHO) declared COVID-19
(Coronavirus disease 2019) a pandemic, many of the public managers faced challenging situations
in their cities due to the simultaneous loss of lives and jobs. In this regard, this study aims to propose
a concise model that considers variables like the number of deaths, lethality of the virus, number
of jobs, and taxes collected by city halls. Our study considers these issues in providing a relevant
response and consistent answer to deliberations on the way forward.

Methods:
Mathematical modeling was used to analyze the interaction between the agents involved,
and computer simulation was chosen to collect results.

Results:
Changing the lockdown level (fixed and variable), the results of number of deaths per
week, the total number of unemployed, cost of companies, and so on are shown.
The levels of lockdowns adopted are: fixed (0%, 40%, 80%, 100%) and variable (30% to 60% and
80% to 40%).

The results show that for the input data considered, the 0% lockdown (LD) policy is more effective
for the economy and tax collection and also succeeds in repressing the effects on the number of
deaths. The comparison between with pandemic and without pandemic is provided (in percentage).

Adopting a 0% LD, it appears to be worse in couple of weeks compared to other LD levels with regard
to the percentage increase in the number of deaths due to the pandemic virus (in particular, +
626% for the 4th week while + 398% for 100% LD). Fortunately, in absolute numbers this quantity
is considered low in relation to the size of the population. The great advantage is seen mainly in tax
collection and number of unemployment generated. For a 0% LD, in the worst scenario, the tax collection
is reduced by 23.68% in the 8th week, while the worst (100% LD) the drop in tax collection
reaches 91.70%. The highest percentage of unemployed generated for 0% LD occurs is in the 16th
week, and for the worst LD (100%), the percentage of generation of unemployed number reaches
106.64%. The number of deaths caused by unemployment, for the worst case of 0% LD also occurs
in the 16th week, with 46.65% while for the 100% LD, the percentage of deaths has increased by
97.48%.

Conclusion:
This study shows that implementing the lockdown did not bring expected benefits, because
instead of reducing the number of deaths due to the COVID-19, individuals tend to die more
from other causes.
Effect of miRNAs, Proinflammatory Cytokines and ACE2 in COVID-19 Pathophysiology
Authors: Singh Hari Om , Jakhar Kamini , Nema Vijay , Krishnaraj Asha , Choudhari Ranjana 
Published: March 2021

Background:
Angiotensin-converting enzyme 2 (ACE2) is the main cellular receptor for
the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and acts as a pro-inflammatory
mediator of Coronavirus disease (COVID-19). The clinical outcome of SARS-CoV-2
infection is influenced by the pro-inflammatory mediators. The specific microRNAs (miRNAs) influence
the ACE2 expression and are accountable for the increased circulatory pro-inflammatory
mediator levels. Thus, host factors play a crucial role in COVID-19 pathophysiology. The pathogenesis
of COVID-19 disease is not well understood. Hence we comprehended the role of miRNAs,
pro-inflammatory cytokines, and ACE2 genes in COVID-19 pathophysiology.

Methods:
We utilized multiple databases, specifically EMBASE, PubMed (Medline), and Google
Scholar, for our search.

Discussion:
SARS-CoV-2 genes could be the target of host miRNAs. The miRNAs regulate the expression
of ACE2 in various organs, including the kidney, heart, blood vessels, and lung. ACE2
acts as a pro-inflammatory mediator of SARS-CoV-2 associated disease. Pro-inflammatory cytokines
(IL-6, IL-1β, and TNF) have been associated with severe COVID-19 disease. Hence variation
in expression of miRNAs would influence the regulation of COVID-19 pathophysiology. The
clinical outcomes of COVID-19 are variable which could be linked with the difference in binding
of host miRNA to the target genes.

Conclusion:
Correlation of these genes with severe or critical stages of patients will provide biomarkers
for the severity of lung inflammation which would be useful in the rapid identification of
patients in need of hospital admission. Analysis of the relationship between the miRNAs and ACE2
will be helpful in designing anti-miR therapy for ACE2-related SARS-CoV-2 infection.
Nilai-nilai dan metode pendidikan karakter di taman kanak-kanak di Banjarmasin
Authors: Siswoyo Dwi , Rukiyati Rukiyati , Hendrowibowo L 
Published: March 2021

Masa usia dini adalah masa yang tepat untuk dikenalkan, dan ditumbuhkan pendidikan moral agar kelak anak menjadi orang yang baik. Selain orang tua, guru memgang peran penting untuk mengembangkan nilai-nilai moral dalam diri anak usia dini di Taman Kanak-Kanak. Tujuan penelitian ini adalah untuk : 1) menganalis nilai-nilai karakter yang menjadi target pendidikan karakter di Taman Kanak-Kanak di kota Banjarmasin; 2) menganalisis metode penanaman nilai karakter yang diterapkan di taman kanak-kanak di kota Banjarmasin. Penelitian ini menggunakan pendekatan deskriptif kualitatif dengan metode pengumpulan data berupa diskusi grup terfokus (focus group discussion). Subjek penelitian ini terdiri dari 30 orang guru TK ‘Aisyiyah di kota Banjarmasin. Analisis data mengikuti langkah-langkah Miles Huberman meliputi, reduksi data, penyajian data dan penarikan kesimpulan. Uji keabsahan data dengan trianggulasi sumber. Hasil penelitian menunjukkan bahwa ada delapan nilai utama yang dikembangkan guru, yaitu religiusitas, respek (hormat menghormati), kemandirian, percaya diri, kejujuran, disiplin, tanggung jawab, dan kerjasama. Metode yang digunakan guru adalah keteladanan, pembiasaan, memberi nasehat, bercerita dan sosiodrama, kunjungan sosial, fasilitasi, bernyanyi, pengenalan dan hafalan hadis singkat. Evaluasi pendidikan moral dilakukan sesuai yang tercantum di dalam kurikulum TK, yaitu menggunakan observasi perilaku anak sehari-hari. Sebagian besar anak telah mencapai perkembangan moral yang baik, dan beberapa anak mendapat nilai sangat baik. Perilaku moral yang paling tampak perkembangannya adalah kemandirian dan rasa percaya diri. Anak telah dapat membaca kitab suci Alquran, dan menghafal beberapa hadis pendek.
Perekayasaan sistem pendidikan nasional untuk mencerdaskan kehidupan bangsa
Authors: Hermanto Bambang 
Published: March 2021

Artikel ini menganalisis kebijakan pendidikan di Indonesia. Sistem pendidikan nasional harus mampu menjamin pemerataan kesempatanpendidikan, peningkatan mutu serta relevansi dan efisiensi manajemen pendidikan untukmenghadapi tantangan sesuai dengan tuntutan perubahan kehidupan lokal, nasional, danglobal sehingga perlu dilakukan pembaharuan pendidikan secara terencana, terarah, danberkesinambungan.Metode yang digunakan dalam penelitian ini adalah analisis media dan studiliteratur.Teknik pengumpulan data yang digunakan berasal dari data primer yang berupa observasi atas fenomena yang terjadi dan data sekunder berupa dokumentasi yang valid. Hasil analisis menunjukkan bahwa Penerapan sistem pendidikan nasional yang baik dan mencerahkan bagi peserta didik tidak denganmeliberalkan sistem pendidikan, tetapimembangun pemikiran bahwa tidak selalu pemerintah, orang tua dan guru lebih tahu yang terbaik bagi peserta didik. Kementerian Pendidikan dan Kebudayaan, serta Kementerian Riset Teknologi dan Pendidikan Tinggi perlu melakukanreformasisecara komprehensifterkaitdenganpelaksanaansistem pendidikannasionaldengancarayangefisien,transparan,dan akuntabel. Pendidikan harus mendapatkanperhatian yang serius bagi setiap bangsa,karena dengan pendidikan akan dapatdilihat maju mundurnya suatu bangsa.Tentu saja bangsa Indonesia tidak ingin hidup terbelakang akibat aspek pendidikantidak mendapat porsi yang cukup dengan beriringnya berbagai kemajuan di bidanglain. Sehingga penting suatu perekayasaan sistem pendidikan nasional untuk mencerdaskan kehidupan bangsa.Kata kunci: Perekayasaan, Kehidupan Bangsa, Mencerdaskan, Sistem Pendidikan Nasional
The Goddess on the Vezirhan Stele
Authors: Kisbali Tamás Péter 
Published: March 2021

The stele from Vezirhan (Istanbul Archaeological Museum, inv. 6219+71.27) is best known for its Old Phrygian and Greek inscriptions (B-05). However, its reliefs also pose an interesting challenge. They include a boar hunt, a ritual banquet scene, and a human figure, commonly identified as a goddess, with lions, birds, and a palmette-like motif “sprouting” from her head.
The stele is dated to the late 5th–early 4th century BC. The hunt and banquet scenes clearly belong to this time (and find many parallels on votive and funerary reliefs and seals of Hellespontine Phrygia).
The image of the goddess, however, continues a different tradition, one that possibly stems from an earlier period. The Vezirhan goddess doesn’t have a singular prototype, but displays connections to a wide variety of iconographical schemes and details. Most are found in the 7th–6th centuries BC arts of Anatolia and the Aegean. By examining this corpus, with special focus on the Potnia theron iconographic type, we understand that the Vezirhan goddess is related to other deities attested in Anatolia (in fact, her name might have been a variation of Artemis, according to line 3 of the Phrygian inscription). Yet, she cannot be identified with any of them directly. For all matches, there are also differences. A certain creative effort was made to distinguish the goddess from her peers, possibly to reflect her local cult.
In my talk, I would like to unfold this synthetic image, examine its components, and try to put them back together – and hopefully gain some insight into how the Vezirhan goddess’ iconographic scheme came to be.
KLASIFIKASI ASPIRASI MAHASISWA DENGAN NAIVE BAYES CLASSIFIER
Authors: Rizqa Ifan 
Published: March 2021

<em>Aspirasi mahasiswa adalah berbagai tuntunan dari mahasiswa yang dikemas dalam ide kreatif untuk mengusulkan proses perubahan atas suatu hal. Rata-rata aspirasi yang disampaikan berupa keluhan dan harapan. Aspirasi berguna sebagai bahan evaluasi dan deteksi dini terhadap kelemahan sistem kualitas perguruan tinggi menjadi lebih baik. kegiatan ini terjadi di UDINUS, DPM sebagai pihak yang mengelola aspirasi mahasiswa. Aspirasi didapatkan melalui sebuah mekanisme yang telah ditentukan seperti penyebaran kuisioner secara manual atau berbasis google form. Kuisioner yang disediakan mengharuskan mahasiswa mengisi isi aspirasi sesuai katagori yang disediakan. Namun, permasalahan yang dihadapi terkadang mahasiswa salah memilih katagori sesuai isi aspirasi yang ditulis. Maka dari itu perlu dibuat sistem yang dapat mengkatagorisasikan aspirasi mahasiswa secara otomatis. Klasifikasi teks dokumen menjadi cara yang paling baik untuk menentukan katagori berdasarkan isi aspirasi mahasiswa. Metode Naïve Bayes Classifier digunakan karena mampu menghasilkan akurasi yang tinggi. Dengan 1000 dokumen data latih yang masing-masing 250 dokumen setiap katagori yaitu “Sarana dan Prasarana”, “Dosen”, “Kepegawaian dan Sistem Akademik”,”Saran dan Masukan” menghasilkan akurasi 90.20%. Dapat dikatakan metode ini layak implementasi dalam penelitian ini. </em>
Trends in orthodontic management strategies for patients with congenitally missing lateral incisors and premolars
Authors: Naoum Steven , Allan Zjana , Yeap Chee Keong , Razza J. Mike , Murray Kevin , Turlach Berwin , Goonewardene Mithran S. 
Published: March 2021

ABSTRACT

Objectives
To identify changes in orthodontic management strategies in patients with hypodontia seen in 2000, 2010, and 2017/2018 (during a 1-year period).

Materials and Methods
An assessment of the panoramic radiographs of 3701 patients from a Western Australian private practice identified 276 individuals demonstrating hypodontia. The location of missing teeth, age, sex, type of malocclusion, and the management strategies (space closure or opening) for each patient were noted.

Results
Most hypodontia involved agenesis of three or fewer teeth (90%). Maxillary lateral incisors and mandibular second premolars were the most commonly missing teeth. Female preponderance was noted. When considering treatment, the odds ratio for orthodontic space opening and prosthetic replacement in 2000 was 3.266 (P value = 7e-04; 95% confidence interval [CI], 1.464–4.633) compared with patients seen in 2010 and 1.632 (P value = 7e-04; 95% CI, 0.811–2.434) compared with patients in 2017/2018. For patients demonstrating bilateral absence of maxillary lateral incisors, the odds ratio for orthodontic space opening was 3.185 (P value = 0.0215; 95% CI, 1.182–9.243) compared with counterparts with unilateral agenesis. None of the factors investigated were significantly associated with the types of treatment planned/provided for the patients with missing mandibular second premolars.

Conclusions
Maxillary lateral incisors and mandibular second premolars were the most commonly missing teeth. A trend away from space opening and prosthetic replacement toward orthodontic space closure was observed from 2000 to 2017/2018. This may reflect a change in attitude toward prosthetic replacement options and/or greater optimism with biomechanical strategies since the implementation of temporary anchorage devices to assist in space closure.
مبررات إنتهاك القانون الدولي في مجال المساواة في السيادة
Authors: Abu Alqasim Layla I. 
Published: March 2021

تتصدر القواعد القانونية الدولية مجموعة القواعد القانونية للمجتمع الإنساني، وذلك لخطورة المسائل التي تعنى بها بالنسبة للجماعات البشرية المختلفة. بالرغم أنها تنبثق كلها ، وإن كانت بدرجات وطرق مختلفة من تعبير الدول السيدة عن إراداتها. وذلك سواء أرادت حقا الاعتراف بالطابع الإلزامي لقاعدة ما، أو نتيجة الالتزام بالعلاقات الاجتماعية الدولية. ومبدأ المساواة في السيادة من القواعد القانونية ، التي تمثل أساس الألتزام وقد يحدث انتهاك لهذه القواعد من بعض الدول، وتستمد المبررات من القوانين الدولية الحــديثة. فالكثير من عوامل الأنتهاك الخفي للقواعد القانونية الدولية، لايمكن الأعتراض عليه لكونه يتفق معها من الناحية النظرية، وتكون نتائجه غير مشروعة
علاقة التسويق عبر الهاتف المحمول بالمستخدمين الشباب
Authors: Zainal Bushra A. 
Published: March 2021

تهدف هذه الدراسة إلى التعرف على مفهوم التسويق عبر الهاتف لكونه أحد أهم الموضوعات التي عادة مايتم الاغفال عنها من قبل منظماتنا لكون معظمها لا يزال يعمل بالطريقة التقليدية، والهدف العملي الآخر هو قياس العلاقة بين التسويق عبر الهاتف المحمول والمستخدمين الشباب باستخدام ادوات التحليل الإحصائية. تعتبر هذه الدراسة مهمة لكونها تتعامل مع أحد الموضوعات الحيوية في الوقت الحاضر والا وهي: كيفية تمكين استخدام التسويق عبر الهاتف المحمول في بيئتنا وعلاقته بقبول المستخدمين الشباب للتقنيات الحديثة للتسويق. لتحقيق أهداف الدراسة ، تم توزيع 87 استمارة استبيان على عينة عشوائية من مستخدمي الهواتف المحمولة ، وبعد ذلك قمنا بتحليل النتائج على برنامج SPSS ، وتم اختبار العلاقة بين كل من متغيرات الدراسة. يمكن تلخيص مشكلة البحث بأسئلة البحث التالية: هل يشعر جميع المستهلكين الشباب بالرضا تجاه إعلانات التسويق عبر الأجهزة المحمولة المستمرة التي يتم عرضها على هواتفهم المحمولة؟ هل تساعد إعلانات التسويق عبر الأجهزة المحمولة المستهلكين على اتخاذ قرار شراء صحيح؟ هل تساهم إعلانات التسويق عبر الأجهزة المحمولة في اقناع المستهلكين الشباب بتغيير قرار الشراء الخاص بهم من منتج إلى آخر؟ وانتهت الدراسة بمجموعة من الاستنتاجات ، أهمها وجود علاقة معنوية بين التسويق عبر الهاتف المحمول والمستهلكين الشباب. بناءً على الاستنتاجات التي توصلت إليها الدراسة ، تم التوصل إلى مجموعة من التوصيات، اهمها ضرورة اهتمام جميع الشركات ببناء بنية تحتية لإعلانات الهواتف المحمولة مرضية، لأن الهواتف المحمولة هي أسهل طريقة للبقاء على اتصال مع المستهلكين في الوقت الحاضر. وتحتاج الشركات إلى استخدام إعلانات موثوقة يتم عرضها للمستهلكين المستهدفين مصحوبة بتجارب حقيقية في استخدام المنتج أو الخدمة.
الطبيعة القانونية لالتزامات الكاتب العدل في صحة السندات الثبوتية في القانون العراقي
Authors: Smael Tahsin H. , Aziz Shahla M. 
Published: March 2021

يعتبر توثيق وتنظيم السندات العمود الفقري من الناحية القانونية لكل نظام اقتصادي والضامن الأساسي للمتعاملين، لذا يتمتع هذا الأخير في كل المجتمعات بأهمية بالغة ومكانة هامة، بحيث قام المشرع العراقي بسن قانون خاص بذلك وهو قانون الكتاب العدول ذو رقم (33) لسنة 1998، واوكل مهام توثيق وتنظيم تلك السندات إلى شخص قانوني وسماه الكاتب العدل، واعطاه الثقة والمصداقية في اعماله، وهو يستمد سلطته من القانون، ويتمتع بحقوق وصلاحيات لا يتمتع بها الشخص العادي، أو غيره من الموظفين العدليين، ومنح للمحررات التي يحررها القوة التنفيذية والرسمية فهي واجبة التنفيذ بذاتها بغير حاجة إلى رفع دعوى واستصدار حكم بالحق الثابت فيها، فإن التوثيق والتنظيم يساهم في تحقيق السلم الاجتماعي واستقرار المعاملات بين الأفراد هذا من جهة، ومن جهة أخرى فإن حدث خطأ من جانبه قد يترتب عليه المسؤولية القانونية، لأن الأعمال القانونية للكاتب العدل متنوعة بحيث تتشابك التزامات وواجبات الكاتب العدل الكثيرة على اصحاب العلاقة والمراجعين، فكان لابد من تحديد التزاماته ومعرفة مدى مسؤوليته ونوع الالتزام التي يفرضه القانون المدني في قيامه بواجباته المدنية وتحديد حسن النية لديه من ضمان توثيق المستندات من قبله ليكون أعماله العدلية ذات التوثيق ويبعث الأمان للمتعاملين مع الدائرة العدلية، ولهذا فان هدفنا هو بيان الطبيعة القانونية للالتزام المدني للكاتب العدل في صحة السندات الرسمية في القانون العراقي، ومتى يكٍون التزامه بتحقيق نتيجة أو ببذل عناية تمهيداً لتكييف مسؤوليته القانونية من عدمه.
Tensile and Impact Properties of Hybrid Composites from Textile Waste
Authors: Mohamad Azminor Amir Hafizin , Zabidi Nurul Syafiqah , Murat Bibi Intan Suraya 
Published: March 2021

The rise of the textile industry in global fashion has caused a high level of post-consumer textile waste generation. Every year, million tons of textile waste has been sent to landfills that consequently leading to environmental pollution. This study aimed to use the textile waste for the development of hybrid composite laminate, together with the existing commercially available fibreglass. This research investigated the tensile properties and impact strength of textile waste hybrid composites. Three textile variants were used in this study, which is lycra, polyester and cotton, and they were either chopped or used as a full fabric. Hand lay-up and hot press technique were used to produce the sample materials, using epoxy resin as the binder. A total of 9 samples were prepared and their tensile and impact properties were assessed. Tensile test results showed that all hybrid composites have a better ultimate tensile strength and tensile modulus compared to their original raw fabrics, but not on the elongation property. It can be seen that the arrangement of fabrics has a distinctive effect on tensile and impact strength. All raw fabrics were greatly punctured during the failure, but all hybrid composites have barely visible impact damage on the front surface, and no penetration was observed. This study reveals that the reuse of textile waste and fibreglass for the development of hybrid composites has a huge potential to be used as substitutes in other composite materials. In the future, this will contribute to improving the sustainability of textile materials.
Pengaruh Iklim Komunikasi Organisasi terhadap Motivasi Kerja Karyawan Telunjuk.com
Authors: Handra Evan Septian , Setyanto Yugih 
Published: March 2021

The digital industry in Indonesia is growing quite rapidly, one of which is marked by the existence of many online shopping platforms. Telunjuk.com is a company that works and serves in the digital-based industry. The purpose of this study was to determine and measure the influence of organizational communication climate on employee motivation at Telunjuk.com. The population in this study has a total of 31 people, with the same number of samples, namely 31 people. This study adapted a total sample or census data collection technique and was calculated using a Likert scale. The data collection techniques in this study made use of a questionnaire and literature study. The validity test in this study uses the validity test and reliability test. The data processing method used is the T test, simple linear regression test, correlation coefficient and determination coefficient. The results showed that: (1) There is a significant influence between organizational communication climate on Telunjuk.com employee motivation, (2) The correlation test results show the Pearson correlation value which shows a very strong relationship between variables, (4) organizational communication climate 64, 1% affects Telunjuk.com employee's work motivation.Industri digital di Indonesia berkembang cukup pesat, salah satunya ditandai dengan adanya banyak platform belanja online. Telunjuk.com merupakan perusahaan yang melayani dalam ruang lingkup industry berbasis digital. Tujuan penelitian ini adalah untuk mengetahui serta mengukur pengaruh iklim komunikasi organisasi terhadap motivasi kerja karyawan di Telunjuk.com. Populasi dalam penelitian ini sejumlah 31 orang, dengan jumlah sample yang sama, yaitu 31 orang. Penelitian ini mengadaptasi teknik pengumpulan data sampel total atau sensus dan dihitung dengan skala Likert. Teknik pengumpulan data dalam penelitian ini memanfaatkan angket kuesioner dan studi kepustakaan. Uji keabsahan dalam penelitian ini menggunakan uji validitas dan uji reliabilitas. Metode pengolahan data yang digunakan adalah uji T, uji analisa regresi linear sederhana, analisa koefisien korelasi dan analisa koefisien determinasi. Penelitian menemukan bahwa: (1) iklim komunikasi organisasi berpengaruh secara signifikan terhadap motivasi kerja karyawan, (2) terdapat hubungan yang sangat kuat antara iklim komunikasi organisasi dan motivasi kerja karyawan, (3) iklim komunikasi organisasi 64,1% berpengaruh terhadap motivasi kerja karyawan.