bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relapsing minimal change disease superimposed on late-onset p.N215S Fabry nephropathy
Authors: Salerno Fabio R , Roggero Letizia , Rossi Federica , Binaggia Agnese , Bertoli Silvio , Pieruzzi Federico 
Published: August 2021

ABSTRACT
We present the case of a 76-year-old man with late-onset Fabry disease caused by the p.N215S missense mutation, with Fabry cardiomyopathy and nephropathy. In this case, the diagnosis of Fabry disease was incidental and followed minimal change disease (MCD) onset, with nephrotic syndrome and acute kidney injury requiring renal replacement therapy. Fabry nephropathy associated with the p.N215S mutation is becoming increasingly recognized among older patients. The importance of electron microscopy is herein highlighted and histological features common to Fabry nephropathy and MCD are discussed, along with the challenges associated with the diagnosis and clinical management.
Humoral response to a third injection of BNT162b2 vaccine in patients on maintenance haemodialysis
Authors: Dekervel Marine , Henry Nicolas , Torreggiani Massimo , Pouteau Lise-Marie , Imiela Jean-Paul , Mellaza Chloé , Garnier Anne-Sophie , Dujardin Amaury , Asfar Marine , Ducancelle Alexandra , Paquin Axelle , Blanchi Sophie , Besson Virginie , Piccoli Giorgina Barbara , Augusto Jean-François 
Published: August 2021

Abstract

Background
Humoral response against sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after two doses of BNT162b2 (Pfizer-BioNTech) has been proven to be less intense in maintenance dialysis patients as compared with healthy subjects, leading the French authorities to recommend a third injection in this population. Here we investigated the response to the third injection in two cohorts of haemodialysis (HD) patients.

Methods
Data from two prospective observational cohorts were collected. In the first (‘systematic’) cohort, patients from two HD centres (n = 66) received a third injection of BNT162b2, regardless of the response after two injections. In the second (‘conditional’) cohort, the injection was only prescribed to patients (n = 34) with no or low response to the previous two doses. In both cohorts, the third dose was injected 1–2 months after the second dose. Serology was performed after the second and third doses to assess anti-Spike immunoglobulin G (S IgG) antibody titre.

Results
In the systematic cohort, anti-S IgG was found in 83.3 and 92.4% of patients after the second and third doses of BNT162b2, respectively. In this cohort, 6/11 (54.5%) and 20/21 (95.2%) patients switched from non-responder to low responder and from low responder to high responder, respectively. In low and high responders to two doses, 50/55 (90.9%) at least doubled their anti-S IgG titre. Similar trends were observed in the conditional cohort.

Conclusions
In maintenance HD patients, humoral response against SARS-CoV-2 was boosted after a third dose of BNT162b2, allowing seroconversion in more than half of non-responders. These data may support an intensified vaccination protocol with a third dose of BNT162b2 in dialysis patients.
A Self-Tallying Electronic Voting Based on Blockchain
Authors: Zeng Gongxian , He Meiqi , Yiu Siu Ming , Huang Zhengan 
Published: August 2021

Abstract
Electronic voting (e-voting) has been studied for many years. Recently, researchers find that blockchain can provide an alternative secure platform for e-voting systems, because of its properties of tamper resistance and transparency. However, existing blockchain-based schemes either require central authorities to tally ballots or can only handle a limited number of voters. This paper tries to propose a self-tallying e-voting system, i.e. the public can verify the validity of all ballots and tally the ballots without a centralized authority. To achieve this goal, we solve two challenges, namely how to cancel out all random numbers used for ballots and to prove the validity of ballots using a non-interactive zero knowledge proof. Our scheme is proved to be secure and shown to be practical by experiments.
Risk prediction in patients with COVID-19 based on haemodynamic assessment of left and right ventricular function
Authors: Taieb Philippe , Szekely Yishay , Lupu Lior , Ghantous Eihab , Borohovitz Ariel , Sadon Sapir , Lichter Yael , Ben-Gal Yanai , Banai Ariel , Hochstadt Aviram , Merdler Ilan , Sapir Orly , Granot Yoav , Laufer-Perl Michal , Banai Shmuel , Topilsky Yan 
Published: August 2021

AbstractAimsCardiovascular involvement is common in COVID-19. We sought to describe the haemodynamic profiles of hospitalized COVID-19 patients and determine their association with mortality.Methods and resultsConsecutive hospitalized patients diagnosed with COVID-19 infection underwent clinical evaluation using the Modified Early Warning Score (MEWS) and a full non-invasive echocardiographic haemodynamic evaluation, irrespective of clinical indication, as part of a prospective predefined protocol. Patients were stratified based on filling pressure and output into four groups. Multivariable Cox-Hazard analyses determined the association between haemodynamic parameters with mortality. Among 531 consecutive patients, 44% of patients had normal left ventricular (LV) and right ventricular (RV) haemodynamic status. In contrast to LV haemodynamic parameters, RV parameters worsened with higher MEWS stage. While RV parameters did not have incremental risk prediction value above MEWS, LV stroke volume index, E/e′ ratio, and LV stroke work index were all independent predictors of outcome, particularly in severe disease. Patients with LV or RV with high filling pressure and low output had the worse outcome, and patients with normal haemodynamics had the best (P &lt; 0.0001).ConclusionIn hospitalized patients with COVID-19, almost half have normal left and right haemodynamics at presentation. RV but not LV haemodynamics are related to easily obtainable clinical parameters. LV but not RV haemodynamics are independent predictors of mortality, mostly in patients with severe disease.
‘CandidatusChloroploca mongolica’ sp. nov. a new mesophilic filamentous anoxygenic phototrophic bacterium
Authors: Bryantseva Irina A , Grouzdev Denis S , Krutkina Maria S , Ashikhmin Aleksandr A , Kostrikina Nadezda A , Koziaeva Veronika V , Gorlenko Vladimir M 
Published: August 2021

ABSTRACTA mesophilic filamentous anoxygenic phototrophic bacterium, designated M50-1, was isolated from a microbial mat of the Chukhyn Nur soda lake (northeastern Mongolia) with salinity of 5−14 g/L and pH 8.0−9.3. The organism is a strictly anaerobic phototrophic bacterium, which required sulfide for phototrophic growth. The cells formed short undulate trichomes surrounded by a thin sheath and containing gas vesicles. Motility of the trichomes was not observed. The cells contained chlorosomes. The antenna pigments were bacteriochlorophyll d and β- and γ-carotenes. Analysis of the genome assembled from the metagenome of the enrichment culture revealed all the enzymes of the 3-hydroxypropionate bi-cycle for autotrophic CO2 assimilation. The genome also contained the genes encoding a type IV sulfide:quinone oxidoreductase (sqrX). The organism had no nifHDBK genes, encoding the proteins of the nitrogenase complex responsible for dinitrogen fixation. The DNA G + C content was 58.6%. The values for in silico DNA‒DNA hybridization and average nucleotide identity between M50-1 and a closely related bacterium ‘Ca. Chloroploca asiatica’ B7-9 containing bacteriochlorophyll c were 53.4% and 94.0%, respectively, which corresponds to interspecies differences. Classification of the filamentous anoxygenic phototrophic bacterium M50-1 as a new ‘Ca. Chloroploca’ species was proposed, with the species name ‘Candidatus Chloroploca mongolica’ sp. nov.
Involvement of RNA granule proteins in meiotic silencing by unpaired DNA
Authors: Xiao Hua , Vierling Michael M , Kennedy Rana F , Boone Erin C , Decker Logan M , Sy Victor T , Haynes Jackson B , Williams Michelle A , Shiu Patrick K T 
Published: August 2021

Abstract
In Neurospora crassa, expression from an unpaired gene is suppressed by a mechanism known as meiotic silencing by unpaired DNA (MSUD). MSUD utilizes common RNA interference (RNAi) factors to silence target mRNAs. Here, we report that Neurospora CAR-1 and CGH-1, homologs of two Caenorhabditis elegans RNA granule components, are involved in MSUD. These fungal proteins are found in the perinuclear region and P-bodies, much like their worm counterparts. They interact with components of the meiotic silencing complex (MSC), including the SMS-2 Argonaute. This is the first time MSUD has been linked to RNA granule proteins.
The dual inverse scaling and squaring algorithm for the matrix logarithm
Authors: Fasi Massimiliano , Iannazzo Bruno 
Published: August 2021

Abstract
The inverse scaling and squaring algorithm computes the logarithm of a square matrix $A$ by evaluating a rational approximant to the logarithm at the matrix $B:=A^{2^{-s}}$ for a suitable choice of $s$. We introduce a dual approach and approximate the logarithm of $B$ by solving the rational equation $r(X)=B$, where $r$ is a diagonal Padé approximant to the matrix exponential at $0$. This equation is solved by a substitution technique in the style of those developed by Fasi & Iannazzo (2020, Substitution algorithms for rational matrix equations. Elect. Trans. Num. Anal., 53, 500–521). The new method is tailored to the special structure of the diagonal Padé approximants to the exponential and in terms of computational cost is more efficient than the state-of-the-art inverse scaling and squaring algorithm.
Consumers as Naive Physicists: How Visual Entropy Cues Shift Temporal Focus and Influence Product Evaluations
Authors: Biliciler Gunes , Raghunathan Rajagopal , Ward Adrian F 
Published: August 2021

Abstract
Marketers often use images to promote their products. For example, an advertisement for kitchen tools might display the tools alongside various ingredients, or an advertisement for a bookstore might showcase pictures of the store’s interior. One underlying visual characteristic of such images is the degree of “entropy”—or disorder—in their content. Motivated by a fundamental principle from physics—namely, that entropy can only increase over time—the present research examines how entropy influences consumers’ judgments and decisions. Across two pilot studies and five experiments, we find that while high-entropy images shift consumers’ temporal focus to the past, low-entropy images shift their temporal focus to the future. These entropy-induced shifts in temporal focus influence consumers’ decisions. Specifically, consistent with the notion of “fit fluency,” we find that consumers evaluate past-related (e.g., vintage) products more favorably when they are accompanied by high-entropy images and future-related (e.g., futuristic) products more favorably when they are accompanied by low-entropy images. We discuss the theoretical and managerial implications of our findings.
Small bowel evisceration from vagina
Authors: Wan Hassan Wan Amir , Narasimhan Vignesh , Arachchi Asiri , Manolitsas Thomas , Teoh William 
Published: August 2021

Abstract
Vaginal evisceration is a rare condition where abdominal contents herniate through a vaginal wall defect. The estimated incidence is 0.032–1.2% after hysterectomy, trachelectomy or upper vaginectomy. We present a 78-year-old lady who developed vaginal evisceration 2 years after radical cystectomy and hysterectomy for bladder cancer. It is rare surgical emergency that requires prompt recognition and damage control with bowel reduction and packing. We discuss the initial management and surgical options for definitive repair.
Inguinal bladder hernia: a case report
Authors: Mejri Ramzi , Chaker Kays , Mokhtar Bibi , Rhouma Sami Ben , Nouira Yassine 
Published: August 2021

Abstract
Inguinal hernia is a common disorder that requires urgent and adequate surgical management. Multiple organs may be associated with inguinal hernias, but bladder involvement is rarely seen. The diagnosis is frequently done during surgery. It can be evoked before surgery when the patient presents with irritative and obstructive lower urinary tract symptoms. Retrograde urethrocystography or intravenous urography confirms the diagnosis. We report a case of inguinal hernia involving the bladder at the right side with a 72-year-old man. We performed a hernia repair after reintegration of the bladder.
Urine Organic Acid Analysis: Key Diagnostic Test for Fumaric Aciduria in a Sri Lankan Child
Authors: Jasinge Eresha , Fernando Mihika , Indika Neluwa-Liyanage R , Trunzo Roberta , Schröder Sabine , Vidanapathirana Dinesha Maduri , Jones Patricia M , Jayasena Subashini , Gunarathne Anusha Varuni , Ratnayake Pyara 
Published: August 2021

Abstract
Fumaric aciduria resulting from fumarate hydratase deficiency is a rare inherited disorder of the Krebs tricarboxylic acid cycle that is characterized by neurologic manifestations, a spectrum of brain abnormalities, and the excretion of fumaric acid in urine. We describe a 3 year old Sri Lankan boy who was referred at age 10 months with poor weight gain and hypotonia for further laboratory investigations. In addition to global developmental delay, there were noticeable dysmorphic features with a prominent forehead, low-set ears, micrognathia, and hypertelorism with persistent neutropenia. Urine organic acid assay revealed a massive elevation of fumaric acid on 2 occasions. Molecular analysis revealed a homozygous likely pathogenic missense variant, NM000143.3:c.1048C&gt;T p. (Arg350Trp), in the FH gene, confirming the biochemical diagnosis. Our patient was the first patient in Sri Lanka molecularly diagnosed with fumaric aciduria. This case study highlights the importance of performing organic acid assays in children presenting with neurologic manifestations especially when these are suspected to have a metabolic basis.
Defining the molecular features of radiation-induced glioma: A systematic review and meta-analysis
Authors: Whitehouse Jacqueline P , Howlett Meegan , Federico Aniello , Kool Marcel , Endersby Raelene , Gottardo Nicholas G 
Published: August 2021

AbstractBackgroundCranial radiation therapy is essential in treating many pediatric cancers, especially brain tumors; however, its use comes with the risk of developing second malignancies. Cranial radiation-induced gliomas (RIGs) are aggressive high-grade tumors with a dismal prognosis, for which no standard therapy exists. A definitive molecular signature for RIGs has not yet been established. We sought to address this gap by performing a systematic review and meta-analysis of the molecular features of cranial RIGs.MethodsA systematic review of the literature was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Articles and case reports that described molecular analyses of cranial radiation-induced high-grade gliomas were identified and evaluated, and data extracted for collation.ResultsOf 1727 records identified, 31 were eligible, containing 102 unique RIGs with molecular data. The most frequent genetic alterations in RIGs included PDGFRA or TP53 mutations, PDGFRA or CDK4 amplifications, and CDKN2A deletion, along with 1q gain, 1p loss and 13q loss. Of note, mutations in ACVR1, EGFR, H3F3A, HIST1H3B, HIST1H3C, IDH2, SMARCB1 or the TERT promoter were not observed. A comparative analysis revealed that RIGs are molecularly distinct from most other astrocytomas and gliomas and instead align most closely with the pedGBM_RTK1 subgroup of pediatric glioblastoma.ConclusionsThis comprehensive analysis highlights the major molecular features of RIGs, demonstrates their molecular distinction from many other astrocytomas and gliomas, and reveals potential genetic drivers and therapeutic targets for this currently fatal disease.
Endovascular Coil Embolization of a Posterior Communicating Artery Aneurysm: 2-Dimensional Operative Video
Authors: Darwal Maureen A , Hakma Zakaria , Binning Mandy J ,   Endovascular Neurosurgery Research Group (ENRG), Arthur Adam , Mark Bain , Bendock Bernard , Binning Mandy Jo , Boulos Alan S , Crowley Webster , Fessler Richard , Grande Andrew , Guterman Lee , Hanel Ricardo , Hoit Daniel , Hopkins L Nelson , Howington Jay , James Robert , Jankowitz Brian , Kan Peter , Khalessi Alex A , Kim Louis , Langer David , Lanzino Giuseppe , Levitt Michael , Levy Elad , Lopes Demetrius , Mack William , Mericle Robert , Mocco J , Ogilvy Chris , Pandey Aditya , Replogle Robert , Riina Howard , Ringer Andrew , Rodriguez Rafael , Saugaveau Eric , Schirmer Clemens , Siddiqui Adnan , Spiotta Alex , Sultan Ali , Tawk Rabih , Thomas Ajith , Turner Raymond , Veznedaroglu Erol , Welch Babu , White Jonathan 
Published: August 2021

Abstract
Since the International Subarachnoid Aneurysm Trial,
1
endovascular treatment has been the favored treatment for appropriate ruptured intracranial aneurysms. While our endovascular technology has advanced to allow us to treat the majority of intracranial aneurysms, simple coil embolization is still the most common modality. This video demonstrates the fundamentals of aneurysm catheterization and coiling for safe treatment. In addition, the set-up and devices are detailed. This video is to add to the library of basic techniques that will aid a large number of practitioners. This patient consented to endovascular treatment. The video demonstrates endovascular coil embolization of a posterior communicating artery aneurysm in a 76-yr-old female who presented with a subarachnoid hemorrhage.
Image of biplane suite in video used courtesy of Siemens Medical Solutions USA, Inc. Illustration at 5:12 reprinted from Yasargil MG, et al, Microneurosurgery IV B, p. 9, Thieme, New York, 1995.
The Decadent Novel
Authors: Mahoney Kristin 
Published: August 2021

Abstract
This article argues that the decadent novel purposefully inverts the conventions of the nineteenth-century realist novel. Rather than developing bourgeois interiority, cultivating moral sympathy, and promoting conventional ideologies of gender and romance, the decadent novel focuses on detached individuals and damaging forms of desire. Refusing to provide reassuring narratives that reinforce myths of progress or camouflage the fractured, fraught nature of modern experience, these texts force readers to confront the anguish produced by modern conditions. They ask readers to meditate on the manner in which the increasing emphasis on individuation and an escalating sense of fragmentation at the turn of the century distort subjectivity and enable ever more horrifying forms of cruelty. In their representations of isolation and sadism, decadent novels amplify and exaggerate late nineteenth- and early twentieth-century forms of alienation in a way that enables further reflection on the dehumanization and deprivation engendered by modernity.
The Decadent Short Story
Authors: Boyiopoulos Kostas 
Published: August 2021

Abstract
The short story form and decadence are not only coterminous in 1890s Britain, but they also share common roots, as both hark back to Edgar Allan Poe. Even though the decadent short story eludes definition, it emphasizes style and rarefied subjectivity against the conventional Victorian novel’s emphasis on plot-driven narratives built around traditional moral values and social concerns. It is a self-conscious cross-genre that explores multifariously the tension between artificiality and life, thus reflecting the experimentalist ethos of its major outlet, the little magazine. In doing so, the decadent short story is distinguished by “excess in quintessence,” a paradox in which morbidity in its thematic and stylistic manifestations is enhanced by the delimiting nature of the form. This paradox makes the decadent short story “plotless,” static, and evanescent. Charlotte Mew’s “Passed” (1894), M. P. Shiel’s “Xélucha” (1895), and Jean Lorrain’s “The Man Who Loved Consumptives” (1891) consummately demonstrate its qualities.
Architecture
Authors: Smithey Lori 
Published: August 2021

Abstract
This article examines how decadence inflected modern architectural thought from the late eighteenth to the late twentieth century, starting with the polemical writings of the French architect Charles-François Viel, who dismissed scientific methods and engineering techniques as inferior to classical tradition. Later, decadence played a part in the Arts and Crafts critique of mechanized industrial production as well as twentieth-century condemnations of the managerial practices of late capitalism. Nevertheless, fin-de-siècle decadent culture also influenced architectural designers and theorists, exemplified by the art nouveau stylings of Charles Rennie Mackintosh and the theoretical writings of Ralph Adams Cram and Geoffrey Scott. From concerns about the sources and causes of social decadence to the aesthetic influence of decadent culture, the works explored here trace interchanges between decadence and modern conceptions of architecture.
France
Authors: Coste Bénédicte 
Published: August 2021

Abstract
Fin-de-siècle French decadence is one expression of the partial autonomy from political power in literature and the arts, both of which established their own frames of reference and legitimation. This article retraces the history of decadence in France in the 1880s. Envisaging decadence as both an infamous appellation and a literary movement embedded within a specific ecosystem of little magazines, it presents canonical works such as Huysmans’s À rebours and the poetry of Paul Verlaine and Stéphane Mallarmé, and explores some notable little magazines where decadent writings first appeared, paying attention to some of the quarrels that led to the emergence of symbolism and instrumentism originating from decadent works in the late 1880s. Literary decadence helped shape the little magazines of the 1890s while also heralding modern poetry.
The Biopolitics of Synthesizers
Authors: D’Errico Mike 
Published: August 2021

Abstract
This chapter outlines how the design of synthesizers and digital instruments in twenty-first-century EDM reflects a biopolitics of software that arises when sound and signal are analogized as dynamic bodies, and the core practices of music production center on the attempt to control, manipulate, and repair those bodies. Combining Tara Rodgers’ work on metaphor in audio-technical discourse and Robin James’s ideas about EDM and the sonic signatures of neoliberalism, this chapter argues that the intersonic control network of synthesizers—a modular, interconnected system of oscillating waveforms, filters, modulation envelopes, and effects—embodies fundamental shifts in the creative practice of electronic music production, the cultural economy of the music products industry, and the nature of labor in the software and media industries. The blurred lines between production and consumption, hardware and software, and labor and leisure define what the author calls the biopolitics of synthesizers. The author details three aspects of these biopolitics in this chapter, including the relationship between synthesizers and masculinity post-2008, synthesizer design and manufacturing as an agent of neoliberal capitalism, and the nature of commodity fetishism and gearlust in an era of plugins, sample packs, and other types of downloadable content.