bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of pre-operative bicarbonate infusion on maternal and perinatal outcomes among women with obstructed labour in Mbale hospital: A double blind randomized controlled trial
Authors: Musaba Milton W. , Wandabwa Julius N. , Ndeezi Grace , Weeks Andrew D. , Mukunya David , Waako Paul , Nankabirwa Victoria , Mugabe Kenneth Tulya-muhika , Semakula Daniel , Tumwine James K. , Barageine Justus K. 
Published: February 2021

Introduction
Oral bicarbonate solution is known to improve both maternal and perinatal outcomes among women with abnormal labour (dystocia). Its effectiveness and safety among women with obstructed labour is not known.

Objective
To determine the effect and safety of a single-dose preoperative infusion of sodium bicarbonate on maternal and fetal blood lactate and clinical outcomes among women with obstructed labour (OL) in Mbale hospital.

Methods
We conducted a double blind, randomised controlled trial from July 2018 to September 2019. The participants were women with OL at term (≥37 weeks gestation), carrying a singleton pregnancy with no other obstetric emergency, medical comorbidity or laboratory derangements.

Intervention
A total of 477 women with OL were randomized to receive 50ml of 8.4% sodium bicarbonate (238 women) or 50 mL of 0.9% sodium chloride (239 women). In both the intervention and controls arms, each participant was preoperatively given a single dose intravenous bolus. Every participant received 1.5 L of normal saline in one hour as part of standard preoperative care.

Outcome measures
Our primary outcome was the mean difference in maternal venous blood lactate at one hour between the two arms. The secondary outcomes were umbilical cord blood lactate levels at birth, neonatal sepsis and early neonatal death upto 7 days postnatal, as well as the side effects of sodium bicarbonate, primary postpartum hemorrhage, maternal sepsis and mortality at 14 days postpartum.

Results
The median maternal venous lactate was 6.4 (IQR 3.3–12.3) in the intervention and 7.5 (IQR 4.0–15.8) in the control group, with a statistically non-significant median difference of 1.2 mmol/L; p-value = 0.087. Vargha and Delaney effect size was 0.46 (95% CI 0.40–0.51) implying very little if any effect at all.

Conclusion
The 4.2g of preoperative intravenous sodium bicarbonate was safe but made little or no difference on blood lactate levels.

Trial registration
PACTR201805003364421.
Metalmorphosen: Die unwahrscheinlichen Wandlungen des Heavy Metal, Jörg Scheller (2020)
Authors: Pichler Peter 
Published: February 2021

Review of: Metalmorphosen: Die unwahrscheinlichen Wandlungen des Heavy Metal, Jörg Scheller (2020)
Stuttgart: Franz Steiner, 286 pp.,
ISBN 978-3-51512-638-0, p/bk, €24.00
EHUko Pedagogia Gradua lanbide anitzetarako prestatzen: ikasleen asebete eta iritzietan eta irakasleen pertzepzioan oinarritutako analisia
Authors: Altuna Jon , Madinabeitia Alba , Marko Inazio , Aierbe Ana , Cruz Esther 
Published: February 2021

Unibertsitatea da herritarren formakuntzan eta profesionalizazioan hezkuntza-instituzio aitzindaria, eta horregatik Pedagogia Graduari eginkizun garrantzitsu horretan prestakuntzaren kalitateari buruz hausnartzea egokitzen zaio. Pedagogoaren lanbideak badu berezitasun bat: hezkuntzako aditu gisa, tradizioz eskola-testuingurura mugatu izan du bere jarduna baina hezkuntza formaletik harago espazio potentzial ugari ditu. Horrekin batera, ordea, bere lekua mu- gatzeko zailtasuna agerikoa da. Hortaz, xxi. mendeko pedagogiari dagokio bere lan-esparrua birdefinitzea eta formakun- tza orientatzeko erronka. Artikulu honen helburu orokorra izan da Euskal Herriko Unibertsitateko (UPV/EHU) Pedagogia Graduko ikasleek eta irakasleek, profesionalizazioaren mapan zehatutako lan-arloak kontuan hartuz zenbateraino haute- maten duten koherentea dela graduan eskaintzen den prestakuntza aztertzea. Lagina 131koa izanik, Pedagogia Graduko 4. mailako 83 ikaslek eta gradu bereko 48 irakaslek parte hartu eta Likert eskaladun galdetegia bete dute. Ikasleen beharrak abiapuntu hartuta azterlan deskribatzaile eta esploratzailea burutu da. Emaitzek erakusten dutenez, ikasleen balorazioa ira- kasleena baino baxuagoa da pedagogiako irakasgaiak pedagogoaren lanbide-irteeretan duten posizioari begiratzen bazaio, eta bien ustez, jasotako prestakuntzan zein lan munduan errepresentazio handiena duen eremua «Ikerketa eta Hezkuntza» da. Aldiz, «Gizartea eta Kultura» eta «Prestakuntza eta Enpresa» gutxien ordezkatutakoak dira. Emaitza hauek orientabi- deak ematen dituzte etorkizunean Pedagogia Graduaren hobekuntzan eta pedagogoaren lanbide-profilaren zehaztasunean aurrera egiteko.
Pengelolaan Pendidikan Karakter Religius Melalui Metode Pembiasaan di Taman Kanak-Kanak
Authors: Hasanah Fitria Fauziah , Munastiwi Erni 
Published: February 2021

Penelitian ini bertujuan untuk mengetahui pengelolaan Pendidikan Karakter Religius Melalui Metode Pembiasaan di TK Ibu Hj Euis Siti Ruyanah Pondok Pesantren Suryalaya Tasikmalaya. Jenis penelitian ini merupakan penelitian kualitatif yang menggunakan teknik pengumpulan data diantaranya dengan observasi, wawancara dan dokumentasi Hasil penelitian pengelolaan pendidikan karakter Religius Melalui Metode Pembiasaan di TK Ibu Hj Euis Siti Ruyanah dilaksanakan meliputi perencanaan, pengorganisaisan, pelaksanaan, dan pengawasan. Kegiatan Pendidikan Karakter Religius Melalui Metode Pembiasaan diantaranya adalah : Pertama, membaca iqra sebelum masuk kelas di pagi hari,; Kedua, membaca doa sebelum belajar, Ketiga, membaca shalawat bani hasyim, Keempat, membaca doa setalah belajar. Faktor Pendukung dalam pengelolaan Pendidikan Karakter Religius Melalui Metode Pembiasaan di TK Ibu Hj Euis Siti Ruyanah Pondok Pesantren Suryalaya Tasikmalaya diantaranya adalah adanya kerjasama antar pendidik, adanya kerjasama antara pendidik dengan orangtua, kondisi lokasi TK yang mendukung, sarana dan prasarana yang memadai, adanya semangat belajar dari anak, terdapat peran dari masyarakat. Adapun faktor penghambatnya yaitu kondisi pekerjaan orangtua, kondisi kepala sekolah yang kurang sehat, dan sumber daya manusia yang belum memenuhi standar kelulusan pendidikan.
Optimalisasi Permainan Lompat Tali dalam Mengembangkan Motorik Kasar Anak
Authors: Mu’mala Khuri Abad , Nadlifah Nadlifah 
Published: February 2021

Anak adalah manusia kecil yang memiliki potensi yang harus dikembangkan. Pada masa ini anak harus distimulasi sebaik mungkin agar kemampuan yang dimiliki anak dapat berkembang secara maksimal. Salah satu penyebab perkembangan motorik kasar tidak berkembang secara optimal adalah kegiatan pengembangan kemampuan motorik kasar tubuh anak yang masih jarang dilaksanakan, sehingga anak kurang terstimulasi dalam mengembangkan kemampuan motorik kasarnya. Banyak sekali kegiatan-kegiatan pembelajaran yang dapat mengembangkan kemampuan motorik kasar anak, salah satunya melalui permainan tradisional lompat tali. Penelitian ini bertujuan untuk mengetahui optimalisasi permainan lompat tali dalam mengembangkan motorik kasar anak usia dini dan faktor apa saja yang mendukung dan menghambat optimalisasi permainan lompat tali dalam mengembangkan motorik kasar anak usia dini Kelompok B2 di TK LKMD Pancasakti Balong Kidul Potorono Banguntapan Bantul Yogyakarta. Jenis penelitian ini adalah penelitian kualitatif deskriptif. Teknik pengumpulan data menggunakan metode observasi, wawancara dan dokumentasi. Subjek penelitian ini yaitu kepala sekolah, guru, wali Muri dan peserta didik Hasil wawancara yang dilakukan dengan kepala sekolah, guru, wali murid, dan peserta didik kemudian dianalisis dengan menggunakan statistik deskriptif. Hasil penelitian menunjukkan bahwa optimalisasi permainan lompat tali dalam mengembangkan motorik kasar anak usia dini kelompok B2 di TL LKMD Pancasakti Balong Kidul Potorono Banguntapan Bantul Yogyakarta yaitu, sudah berjalan dengan cukup baik, karena dapat mengembangkan koordinasi mata, tangan, kaki, dan menyenangkan hati anak) Faktor-faktor yang mendukung dan menghambat optimalisasi permainan lompat tali dalam mengembangkan motorik kasar anak usia dini Kelompok B2 di TK LKMD Pancasakti Balong Kidul Potorono Banguntapan Bantul Yogyakarta yaitu, faktor pendukung, yaitu organ fisik yang lengkap, kematangan perkembangan, dan faktor pada apa yang dimakan oleh anak. Faktor penghambat, yaitu kondisi lingkungan di sekitar, dan pola asuh orang tua terhadap anak.
Development and control of a home-based training device for hand rehabilitation with a spring and cable driven mechanism
Authors: Serbest Kasim , Kutlu Mustafa , Eldogan Osman , Tekeoglu Ibrahim 
Published: February 2021

Abstract
Rehabilitation at home is rapidly increasing. Although successful results are achieved with treatment methods applied in rehabilitation clinics, there are also some disadvantages in this process, such as dependence on an expert and high costs. Developments in mechatronic technologies have accelerated the development of assistive devices which are designed for use at home. One of the rehabilitation applications is on a hemiplegic hand. In previous studies, some useful devices have been developed for hand rehabilitation. In this study, we suggest a new, low-cost and wearable robotic glove for hand rehabilitation. The specific component of this device is the spring and cable driven system proposed for transmission of motion and force. The device was tested on both unimpaired participants and patients with the hemiplegic hand, and it was proven to be beneficial for hand rehabilitation. As a result of trials with unimpaired participants, the muscle activation of the extensor digitorum and the flexor carpi radialis were increased by 184.1 and 197.8% respectively. The weight of the device was less than 400 g, thanks to 3D printed parts.
Glycine and L-Arginine supplementation ameliorates gastro-duodenal toxicity in a rat model of NSAID (Diclofenac)-gastroenteropathy via inhibition of oxidative stress
Authors: Akinrinde Akinleye Stephen , Hameed Halimot Olawalarami 
Published: February 2021

Abstract

Objectives
This study examined the possible protective roles of exogenous glycine (Gly) and L-Arginine (l-Arg) against Diclofenac (DIC)-induced gastro-duodenal damage in rats.

Methods
Rats were divided into Group A (control), Group B (DIC group) and Groups C–F which were pre-treated for five days with Gly1 (250 mg/kg), Gly2 (500 mg/kg), l-Arg1 (200 mg/kg) and l-Arg2 (400 mg/kg), respectively, before co-treatment with DIC for another three days. Hematological, biochemical and histopathological analyses were then carried out.

Results
DIC produced significant (p<0.05) reduction in PCV (13.82%), Hb (46.58%), RBC (30.53%), serum total protein (32.72%), albumin (28.44%) and globulin (38.01%) along with significant (p<0.05) elevation of serum MPO activity (83.30%), when compared with control. In addition, DIC increased gastric H2O2 and MDA levels by 33.93 and 48.59%, respectively, while the duodenal levels of the same parameters increased by 19.43 and 85.56%, respectively. Moreover, SOD, GPx and GST activities in the DIC group were significantly (p<0.05) reduced in the stomach (21.12, 24.35 and 51.28%, respectively) and duodenum (30.59, 16.35 and 37.90%, respectively), compared to control. Treatment with Gly and l-Arg resulted in significant amelioration of the DIC-induced alterations although l-Arg produced better amelioration of RBC (29.78%), total protein (10.12%), albumin (9.93%) and MPO (65.01%), compared to the DIC group. The protective effects of both amino acids against oxidative stress parameters and histological lesions were largely similar.

Conclusions
The data from this study suggest that Gly or l-Arg prevented DIC-induced gastro-duodenal toxicity and might, therefore be useful in improving the therapeutic index of DIC.
Evaluation of a Simple and Affordable Image-Based Procedure to Measure Particle Size Distribution
Authors: Ferrer B. , Nostas C. , Mas D. 
Published: February 2021

Abstract
The classical measurement method of particle size for sands and gravels is sieving, but in recent years, imaging methods have been shown to be more reliable. However, imaging procedures require specialized devices (such as Camsizer), proprietary software (such as Optgran-CS), dedicated illumination, or other issues. Furthermore, image resolution in digital cameras improves constantly over time, including in cameras in cellular phones, which leads to the idea that using a standard commercial device and a simple procedure could give results that could be accurate enough. In this work, we first define a simple way of finding the particle size distribution without using any special device, only with a commercial camera and a well-known free image-processing software. Once defined, we analyze the error magnitude and dispersion of the method with different samples and light intensities. To make the procedure even more accessible, the use of a smartphone camera is also studied. The results show that the method can be used taking into account a correction factor within a narrow interval, which makes this simple method also robust.
Fatal epidural abscess from diabetic foot disease
Authors: Sharma Aditi , Thaventhiran Thilipan , Braggins Suzanne , Jayasena Channa N , Bravis Vassiliki 
Published: February 2021

Summary
Infection is a common complication of advanced diabetic foot disease, increasing the risk of acute admission and amputation. It is less well-known that foot ulceration and osteomyelitis may cause bacteraemia-associated hematogenous seeding and subsequent epidural abscess formation. Here we describe the case of a 57-year-old woman with known diabetic foot ulcer with underlying osteomyelitis admitted with backpain in the absence of trauma. Her condition deteriorated secondary to overwhelming sepsis. MRI of the spine confirmed spondylodiscitis and posterior epidural collection, not amenable to surgical intervention due to patient’s comorbidities and high surgical risk. Despite prolonged antibiotic therapy, the patient died following a hospital admission lasting 2.5 months. This case highlights the importance of regular contact with diabetes foot service for optimisation and prompt treatment of diabetic foot disease, which can be an underestimated potential source of remote site invasive systemic infection. Secondly, high clinical suspicion in admitting clinicians is imperative in ensuring timely diagnosis and early intervention to minimise fatal consequences.

Learning points:

Approximately 10% of patients with diabetes will develop a foot ulcer in their lifetime.

Spondylodiscitis (incorporating vertebral osteomyelitis, spondylitis and discitis) is a rare condition and diabetes is the most common predisposing risk factor.

Spondylodiscitis often presents with no other symptom other than back pain. Neurological or infective symptoms can be present or absent.

High clinical suspicion in clinicians is imperative in ensuring timely diagnosis and early intervention to minimise devastating consequences.
Perlindungan Hukum Terhadap Merek Dagang Asing Yang Belum Terdaftar di Indonesia
Authors: Suhartono Mohammad , Farihah Ipah 
Published: February 2021

AbstrakMerek merupakan hal yang penting dalam perkembangan ekonomi bagi pengusaha, sehingga tidak sedikit pengusaha yang memanfaatkan dan tidak bertanggung jawab menggunakan, meniru dan bahkan mendaftarkan merek terkenal orang lain atas nama dirinya. Penelitian ini menggunakan metode penelitian yurisdis normatif dengan menggunakan metode perundang-undangan (Statue Approach), dan pendekatan kasus (Case Approach) pendekatan kepada Perundang-undangan Nomor 15 Tahun 2001 tentang Merek. Sedangkan pendekatan kasus berdasarkan Putusan Mahkamah Agung 557 K/Pdt.Sus-HKI/2016. Hasil penelitian menunjukkan bahwa merek dagang asing dilindungi selama merek tersebut sudah terdaftar di negaranya dalam hal ini negara anggota konvensi, peraturan-peraturan tersebut dibebaskan dalam penerapannya oleh setiap anggota konvensi. Akan tetapi kebebasan dalam hal ini kebebasan yang tidak bertentangan dengan ketentuan-ketentuan konvensi internasional. Adapun pertimbangan hakim Pengadilan Niaga memutuskan menolak legal standing penggugat dengan alasan yang mengajukan bukanlah badan hukum yang bersangkutan. Mahkamah Agung telah dinyatakan sudah tepat karena pertimbangan-pertimbangan yang dilakukan oleh hakim sudah sesuai dengan perundang-undangan yang berlaku. Kata Kunci : Perlindungan Merek, Merek Terdaftar, Merek Asing.
Pengelolaan Wakaf Ditinjau Dari Hukum Islam dan Hukum Positif; Studi Kasus Yayasan Taman Mandiri Syari’ah Tangerang Banten
Authors: Birowo Heru , Iswandi Irvan 
Published: February 2021

Taman Mandiri Syari'ah Foundation is an organization in the social, humanitarian and religious. The foundation aims to raise the social dignity of orphans and poor people with zakat, infaq, shodaqoh, and waqf that are permitted by the Shari'a and legal funds from individuals, companies, community groups, or other institutions. The study uses Qualitative method with literary and empirical approach. The findings of this study are state waqf management of Taman Mandiri Syari'ah Foundation, based on the perspective of Islamic Law and Positive Law, the waqf process of Taman Mandiri Syari'ah Foundation, the provisions of the waqf have required the pillars and conditions. Yet the waqf letter, YTS as Nadzir for land waqf in Depok, has not completed the waqf document by register to National Land Agency. The waqf management has doing are land waqf and cash waqf.Keywords: Waqf, Management, Law. AbstrakYayasan Taman Mandiri Syari’ah merupakan lembaga yang bergerak di bidang sosial, kemanusiaan dan keagamaan. Yayasan ini dibangun dengan tujuan mengangkat harkat sosial kemanusiaan kaum yatim dan dhuafa dengan dana zakat, infak, shodaqoh serta wakaf dan dana-dana yang dihalalkan oleh syariat dan legal, baik dari perorangan, perusahaan, kelompok masyarakat, atau sumber lembaga lainnya. Penelitian ini menggunakan metode penelitian Kualitatif, dengan pendekatan literatur dan empiris. Hasil penelitian ini menyatakan bahwa Pengelolaan wakaf di Yayasan Taman Mandiri Syari’ah, berdasarkan tinjauan Hukum Islam dan Hukum Positif, proses perwakafan di Yayasan Taman Mandiri Syari’ah, ketentuan wakafnya sudah memenuhi rukun dan syarat. Namun dalam kelengkapan surat wakaf, YTS sebagai Nadzir atas wakaf tanah di Depok, belum melengkapi surat wakaf yang seharusnya didaftarkan ke Badan Pertanahan Nasional (BPN). Pengelolaan wakaf yang sudah berjalan di Yayasan Taman Mandiri Syari’ah berupa wakaf tanah dan wakaf tunai.Kata Kunci: Pengelolaan, Wakaf, Hukum
Implikasi Perubahan Konstitusi 1945-1959 Terhadap Sistem Pemerintahan Indonesia
Authors: Turyana Nana , Rohmah Siti Ngainnur 
Published: February 2021

The Indonesian constitution has undergone several changes, namely in 1949, 1959, and during the reform era. Changing the constitution in a country can result in changing the system of government in that country. Each law that is made can carry its own characteristics, including in the government system regulated in the 1945 Constitution. The study uses Qualitative method with literary and empirical approach. The findings of this study are the constitution of Indonesia have long of history. The canges on constitution therefor implication to system of goverment because the constitution are rules.Keywords: Implication. Constitution, System, Governance AbstrakKonstitusi Indonesia sudah mengalami perubahan beberapa kali yaitu pada tahun 1949, 1959, dan pada masa reformasi. Berubahnya konstitusi pada suatu negara dapat mengakibatkan berubahnya sistem pemerintahan di negara tersebut. Setiap hukum yang dibuat dapat membawa ciri khas tersendiri, termasuk dalam sistem pemerintahan yang diatur dalam UUD 1945. Penelitian ini menggunakan metode penelitian Kualitatif, dengan pendekatan literatur dan empiris. Hasil penelitian ini menyatakan bahwa Konstitusi di Indonesia mempunyai sejarah yang panjang. Perubahan pada konstitusi berdampak sistemik terhadap berubahnya sistem pemerintahan karena konstitusi adalah aturan sedangkan pemerintahan adalah alat untuk mencapai tujuan yang tertuang pada aturan (konstitusi). Kata Kunci: Implikasi, Konstitusi, Sistem, Pemerintahan
The miR-1906 mimic attenuates bone loss in osteoporosis by down-regulating the TLR4/MyD88/NF‐κB pathway
Authors: Xie H. , Cao L. , Ye L. , Shan G. , Song W. 
Published: February 2021

AbstractIn this study, the ability of microRNA-1906 (miR-1906) to attenuate bone loss in osteoporosis was evaluated by measuring the effects of a miR-1906 mimic and inhibitor on the cellular toxicity and cell viability of MC3T3‐E1 cells. Bone marrow-derived macrophage (BMM) cells were isolated from female mice, and tartrate-resistant acid phosphatase signalling was performed in miR-1906 mimic-treated, receptor-activated nuclear factor kappa-B (NF-κB) ligand (RANKL)-induced osteoclasts. In-vivo, osteoporosis was induced by ovariectomy (OVX). Rats were treated with 500 nmol/kg of the miR-1906 mimic via intrathecal administration for 10 consecutive days following surgery. The effect of the miR-1906 mimic on bone mineral density (BMD) in OVX rats was observed in the whole body, lumbar vertebrae and femur. Levels of biochemical parameters and cytokines in the serum of miR-1906 mimic-treated OVX rats were analysed. The mRNA expression of toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), p-38 and NF-κB in tibias of osteoporotic rats (induced by ovariectomy) was observed using quantitative reverse-transcription polymerase chain reaction. Treatment with the miR-1906 mimic reduced cellular toxicity and enhanced the cell viability of MC3T3‐E1 cells. Furthermore, osteoclastogenesis in miR-1906 mimic-treated, RANKL-induced osteoclast cells was reduced, whereas the BMD in the miR-1906 mimic-treated group was higher than in the OVX group of rats. Treatment with the miR-1906 mimic also increased levels of biochemical parameters and cytokines in the serum of ovariectomised rats. Finally, mRNA expression levels of TLR4, MyD88, p-38 and NF-κB were lower in the tibias of miR-1906 mimic-treated rats than in those of OVX rats. In conclusion, the miR-1906 mimic reduces bone loss in rats with ovariectomy-induced osteoporosis by regulating the TLR4/MyD88/NF‐κB pathway.
The impact of water in architectural thinking
Authors: Heckenast Gábor , Ferencz Marcel , Kertész András Tibor 
Published: February 2021

AbstractThe focus of this research is the connection between architecture and water, how this natural element has formed the way of thinking. To give a complex answer, it is required to observe this complex topic from different aspects: time, space (with macro and micro space typology), meaning, technology, art and architectural design method, which all together can create a network of ideas. This outlined network could provide a theoretical basis for a new complex design method – from the building scale to the urban scale – for the upcoming challenges of built environment in connection with water in the future.
The potential of residential area – A practice design at Roissypole
Authors: Lu Chang , He Honghao , Zhao Tianyu , Borsos Agnes , Gyergyak Janos 
Published: February 2021

AbstractThe Roissypole is a complex residential area within Charles de Gaulle airport in Paris. There are already accommodations of different levels with bars, cafes and more in this area, but there is a lack of simple connection between existing buildings, which help brings life to the outside atmosphere. The proposed concept is not a simple public facility renew instead of a new social and functional design, which is to reinvent the airport region design to transform the Roissypole district into an appealing enjoyable and lively living environment. While enhancing the life quality for both long and short-term residents, for people to share their life, live in an active way, it also provides passive life and initiative social activities, which form a new lifestyle.