bluuebunny/crossref_metadata_2025_split huggingface dataset:
CYTOTOXIC PROPERTIES OF NANOSTRUCTURES BASED ON ALUMINUM OXIDE AND HYDROXIDE PHASES IN RELATION TO TUMOR CELLS
Authors: Lozhkomoev A. S. , Bakina O. V. , Kazantsev S. O. , Ivanova L. Yu. , Avgustinovich A. V. , Afanasyev S. G. , Spirina L. V. , Dobrodeev A. Yu. 
Published: August 2021

Background. Currently, the use of nanoparticles and nanostructures as components of tumor therapy is the subject of numerous scientific articles. To change the parameters of cell microenvironment in presence of nanoparticles and nanostructures is a promising approach to reducing the tumor cell viability. Aluminum hydroxides and oxides have a number of advantages over other particles due to their porous surface, low toxicity, and thermal stability.The purpose of the study was to investigate the influence of the acid-base properties of aluminum hydroxide structures with different phase composition on the tumor cell viability (Hela, mda, pymt, a549, B16F10).Material and methods. Aln/al nanoparticles were used as a precursor for obtaining structures with various phase compositions. The anoparticles were produced by electric explosion of an aluminum wire in a nitrogen atmosphere. Such nanoparticles interact with water at 60 °Ϲ, resulting in formation of porous nanostructures. They are agglomerates of nanosheets with a planar size of up to 200 nm and a thickness of 5 nm. The phase composition of the structures was varied by the calcination temperature. A change in the phase composition of nanostructures led to a change in the acid-base properties of their surface. To estimate the number of acidic and basic centers on the surface of nanostructures, the adsorption of Hammett indicators was used. The amount of adsorbed dyes was determined spectrophotometrically.Results. It was found that the differences in the acid-base characteristics of the surface of the nanostructures led to a change in their antitumor activity. Γ-al2o3 had 6.5 times more basic centers than acidic ones, which determined its ability to exhibit more pronounced antacid properties, i.e. Longer to neutralize protons secreted by tumor cells. This sample had the highest antitumor activity against all tested cell lines.Conclusion. The antitumor activity of synthesized structures was found to be related not only to an increase in the ph of the cell microenvironment, but also to the ability to maintain the alkalinity of the microenvironment for a longer time due to the adsorption of protons released by tumor cells.
RADIATION-INDUCED TOXICITY IN BREAST CANCER PATIENTS TREATED WITH TRASTUZUMAB-BASED CHEMOTHERAPY
Authors: Karabut R. Yu. , Vazhenin A. V. , Mozerova E. Y. , Sarycheva M. M. , Lozhkov A. A. , Maksimovskaya A. Yu. , Timokhina D. M. 
Published: August 2021

The aim of the study was to determine and analyze the most significant risk factors for developing cardiac, pulmonary and skin toxicities among patients who received concurrent radiation therapy and chemotherapy with trastuzumab.Material and methods. The study included 66 patients with histologically verified invasive intermediate or low-grade breast carcinoma, who received radiation therapy and chemotherapy with trastuzumab from 2018 to 2019. The average age of the patients was 53.1 ± 4.2 years. Locally advanced stage iii a and iii b breast cancer was the most common (52 %) followed by stage ii a and ii b cancer (36 %). The lvef of all patients was ≥50 %. All patients received neoadjuvant chemotherapy with anthracyclines and/or taxanes. Radiation-induced side effects were assessed using the rtog/eortc scoring criteria. Dose-volume histogram (dvh) of radiotherapy planning was matched to the quantec criteria.Results. Radiation-induced pulmonitis was observed in 2 patients within 2 to 6 months after the completion of radiation therapy. A 10 % reduction in lvef was observed in 3 patients, while a 20 % decrease in ef was not found. Long qt syndrome was observed in 3 patients, and it was accompanied by clinical manifestations in 2 patients. When evaluating the echo-cg protocols after treatment, normal lv diastolic function was recorded in 39 patients, moderate diastolic dysfunction (lv dd) in 27, and 1 patient had severe lv dd. When assessing the dose received by the lv myocardium, the excess of the average dose to the myocardium was present both on the left and on the right. Only in 16 % of cases, left myocardial irradiation met criterion v 25. Clinically, arrhythmias, unstable angina pectoris, and other manifestations of coronary artery disease were mostly observed among patients with left-sided breast cancer. Significant factors for the development of cardiotoxicity were left-sided breast cancer, previous chemotherapy with anthracyclines and/or taxanes, as well as myocardial doses. The occurrence of radiation pulmonitis did not show an obvious relationship with any factor, while the body mass index (bmi) of >30 was a significant factor for the occurrence of radiation-induced skin damage.Conclusion. The combination of radiation therapy and trastuzumab was associated with an acceptable risk of cardiotoxicity. Monitoring of the cardiovascular system parameters during treatment and detection of early signs of cardiotoxicity were shown to be of great importance.
Data filtering methods for SARS-CoV-2 wastewater surveillance
Authors: Arabzadeh Rezgar , Grünbacher Daniel Martin , Insam Heribert , Kreuzinger Norbert , Markt Rudolf , Rauch Wolfgang 
Published: August 2021

AbstractIn the case of SARS-CoV-2 pandemic management, wastewater-based epidemiology aims to derive information on the infection dynamics by monitoring virus concentrations in the wastewater. However, due to the intrinsic random fluctuations of the viral signal in wastewater caused by several influencing factors that cannot be determined in detail (e.g. dilutions; number of people discharging; variations in virus excretion; water consumption per day; transport and fate processes in sewer system), the subsequent prevalence analysis may result in misleading conclusions. It is thus helpful to apply data filtering techniques to reduce the noise in the signal. In this paper we investigate 13 smoothing algorithms applied to the virus signals monitored in four wastewater treatment plants in Austria. The parameters of the algorithms have been defined by an optimization procedure aiming for performance metrics. The results are further investigated by means of a cluster analysis. While all algorithms are in principle applicable, SPLINE, Generalized Additive Model and Friedman's Super Smoother are recognized as superior methods in this context (with the latter two having a tendency to over-smoothing). A first analysis of the resulting datasets indicates the positive effect of filtering to the correlation of the viral signal to monitored incidence values.
Removal of total nitrogen from wastewater by a combination of Chlorella sp. and audible sound
Authors: Pham Thanh-Luu , Tran Uyen Phuong , Bui Nghia Hiep , Bach Thuy Thi Ngoc , Van Tran Binh , Bui Xuan Thanh , Phan Tam Minh , Bui Ha Manh 
Published: August 2021

Abstract
In developing countries, nitrogen in the traditional market wastewater is a critical environmental problem. In this study, the microalga Chlorella sp., which was isolated from wastewater, was used to remove the total nitrogen (TN) from conventional market wastewater in combination with audible sound (Vietnamese classical music). In addition, effects of sound exposure on removal efficiency at different initial cell densities were analyzed. Results revealed that music sound control demonstrates potential to improve the removal efficiency. TN removal efficiencies of 96%, 69.5%, and 4.3% were observed for treatments with Chlorella sp./audible sound, Chlorella sp., and without Chlorella sp., respectively. The significance of probability value (p-value) (&lt;0.05) on the paired sample t-test confirmed the critical role of audible sound and Chlorella sp. density on the TN removal in screening experiments. The predicted optimal conditions for TN removal were as follows: a Chlorella sp. density of 4%, an audible sound of 52.5 dB, and a cultivation time of 4.6 days. Results based on statistical analysis revealed that the quadratic models for TN removal are significant at a low p-value (&lt;0.05) and a high predicted coefficient of determination (R2 = 0.9452) value. The obtained statistical results also indicated that most of the variables are significant for the abatement of TN from market wastewater using Chlorella sp.
Adsorption modeling of organic compounds (OCs) by carbon nanotubes (CNTs): role of OC and CNT properties on the linear solvation energy relationship
Authors: Ersan Gamze 
Published: August 2021

Abstract
This study evaluated a comprehensive database for the adsorption of polar and nonpolar organic compounds (OCs) by carbon nanotubes (CNTs) and to use the linear solvation energy relationship (LSER) technique for developing predictive adsorption models of OCs by multi-walled carbon nanotubes (MWCNTs) and single-walled carbon nanotubes (SWCNTs). The results showed that coefficient of determinations (R2) values for all compounds are higher variability in the 200 g/mol molecular weight cutoff (74–99%). When the molecular weight cutoff of all OCs is higher than 200 g/mol, the trend of their R2 values is decreased (less than 70%). Among all adsorbate descriptor coefficients, V and B terms are the most significant descriptors (p-values ≤ 0.05) in LSER equations for adsorption of low molecular weight polar and nonpolar OCs by both CNTs. Besides, KOW normalization of all Kd values did not have significant impact on the regression of the LSER model, indicating that hydrophobic interactions are not sole mechanism for the adsorption of OCs on CNTs. Lastly, SWCNTs exhibited higher polar OCs uptake than MWCNTs, which was attributed to more polar surface of SWCNTs as suggested by its high oxygen content (%10).
Artistic genesis of the mausoleum of Józef Fraget at old Powązki cemetery in Warsaw
Authors: Wiraszka Marta 
Published: August 2021

Neoclassical mausoleum of Józef Fraget (1797-1867) commemorating a French industrial entrepreneur and the founder of the first factory of clad goods in Poland was constructed at Old Powązki Cemetery in Warsaw between 1867 and 1869 (quarter A, row I). The author of the torso is Leonard Marconi, and the mold is believed to have been made by the “Lilpop, Rau i Loewenstein” factory in Warsaw. The original project embraced only the top, cast iron part of the tomb in the form of Doric aedicule with entablature and triangular pediment as well as the marble torso placed on prism pedestal located among four columns. The bottom, stone part, was executed later, approximately in 1913 in Władysław Tuszyński stone enterprise.
The Mausoleum of Fraget is a replica of the monument situated in Berlin at St. Dorothy’s Cemetery commemorating Johann August Borsig (1804-1854), the owner of the well-established metal factory in Europe. Its designer was an architect from Berlin, an apprentice of Schinkl, Johann Heinrich Strack, and the maker of the bronze torso mold was asculptor Christian Daniel Rauch. Three other mausoleums originated from the same model: the Brand family mausoleum at the Metallurgical Cemetery in Gliwice, (between 1865 and 1890), Tomas Evans mausoleum at the Evangelical Reformed Cemetery in Warsaw (second half of the 60s. the XIX century, currently non-existent) and in its slightly modified form, the tomb of the architect J. H. Strack at the St Dorothy’s Cemetery in Berlin (1880-1882).
All the above -mentioned mausoleums except the monument decorating the tomb of the architect Strack, commemorated personalities from metallurgical industry. The particularity of the mausoleum of Józef Fraget consists in the use of cast iron as the main constructing element. It is a distinctive feature differing the mausoleum in question from the remaining exemplary monuments made of stone.
O uso educativo da gamificação do Trânsito: uma análise de jogos de Trânsito disponíveis na plataforma Play Store
Authors: Igor Santos Góes  , Janille Costa Pinto  , Verônica Bastos Nascimento  , Cátia Regina Conceição dos Santos  
Published: August 2021

Este artigo apresenta reflexões sobre o uso educativo da gamificação sobre a temática Trânsito, que estão disponíveis na plataforma virtual Play Store, o qual tem como um dos seus objetivos analisar as características e utilização dos jogos educativos sobre o Trânsito nessa plataforma supracitada. Nesse contexto, optamos por coletar dados mediante pesquisa de campo na plataforma virtual do Play Store. Visa identificar quais são os jogos educativos que a mesma. Verificar suas características, os conteúdos abordados sobre Trânsito, bem como a sua utilização pelos usuários. Justifica-se a presente investigação pela necessidade de divulgar os jogos educativos relacionados ao Trânsito, que estão em consonância com a Portaria Departamento Nacional de Trânsito nº 147 de 02/06/2009 que prova as Diretrizes Nacionais da Educação para o Trânsito na Pré-Escola e no Ensino Fundamental. Concluímos que há uma grande quantidade de jogos disponíveis relacionados ao Trânsito que podem ser utilizado no contexto escolar e pessoal para desenvolver habilidades, competências e novos conhecimentos.
Predicting Chromosome Flexibility from the Genomic Sequence Based on Deep Learning Neural Networks
Authors: Peng Jinghao , Peng Jiajie , Piao Haiyin , Luo Zhang , Xia Kelin , Shang Xuequn 
Published: August 2021

Background:
The open and accessible regions of the chromosome are more likely to be
bound by transcription factors which are important for nuclear processes and biological functions. Studying
the change of chromosome flexibility can help to discover and analyze disease markers and improve
the efficiency of clinical diagnosis. Current methods for predicting chromosome flexibility based
on Hi-C data include the Flexibility-Rigidity Index (FRI) and the Gaussian Network Model (GNM), which
have been proposed to characterize chromosome flexibility. However, these methods require the chromosome
structure data based on 3D biological experiments, which is time-consuming and expensive.

Objective:
Generally, the folding and curling of the double helix sequence of DNA have a great impact
on chromosome flexibility and function. Motivated by the success of genomic sequence analysis in biomolecular
function analysis, we hope to propose a method to predict chromosome flexibility only
based on genomic sequence data.

Methods:
We propose a new method (named "DeepCFP") using deep learning models to predict chromosome
flexibility based on only genomic sequence features. The model has been tested in the
GM12878 cell line.

Results:
The maximum accuracy of our model has reached 91%. The performance of DeepCFP is close
to FRI and GNM.

Conclusion:
The DeepCFP can achieve high performance only based on genomic sequence.
Real-World Data Regarding Long-Term Administration of Natalizumab
Derived from a Neurology Department along with Literature Review
Authors: Davidescu Eugenia Irene , Odajiu Irina , Sandu Constantin-Dragoș , Ghergu Amalia , Luca Dimela , Mureșanu Dafin Fior , Popescu Bogdan Ovidiu 
Published: August 2021

Background:
Natalizumab is a humanized monoclonal antibody with high efficacy and
an acceptable safety profile used in the treatment of patients with multiple sclerosis (MS).

Objectives:
Our aim was to report data regarding long-term administration of Natalizumab in patients
with Relapsing-Remitting Multiple Sclerosis (RRMS) from our clinic.

Methods:
A retrospective observational study was performed including RRMS patients who underwent
treatment with ≥ 24 Natalizumab infusions. We analyzed EDSS values, the relapse rate and
the rate and type of adverse events related to Natalizumab administration.

Results:
51 subjects were included with a predominance of women (62.74%), with an average age
of 40.43±1.49 years, a mean disease duration of 9.86±0.7 years and mean number of Natalizumab
infusions of 45.58±2.74. An increased number of patients (80.39%) were relapse-free and a mild reduction
of the mean EDSS value following Natalizumab initiation in patients who had not been
treated with other disease modifying therapies anteriorly was observed. Among the encountered adverse
events such as increased liver transaminases (13.72%), local infections (7.84%) and dysmenorrhea
in one patient were registered in this study. The rate of severe adverse events was 3.92 and
no cases of Progressive Multifocal Leukoencephalopathy (PML) were registered.

Conclusions:
Natalizumab proves to be effective, has an adequate safety profile and can be administered
with good tolerability for a rather extended period of time, provided that the patients are closely
monitored.
Síndrome de Reacción a drogas con Eosinofilia y Síntomas Sistémicos (DRESS) asociados a Nefritis Túbulo Intersticial Aguda en un adolescente
Authors: Bustamante Gañán Inés Bibiana 
Published: August 2021

El síndrome de DRESS (Reacción a drogas con eosinofilia y síntomas sistémicos) es una patología poco frecuente en Pediatría, descrita por primera vez en 1996, por Bocquet. Puede presentarse en un tiempo variable luego de exposición a algunos medicamentos, se caracteriza por fiebre, compromiso cutáneo y de órganos internos. En este caso, se presenta a un paciente de 13 años, con antecedente de uso de Trimetroprim sulfa desde hace 2 meses, con cuadro de 3 días consistente en fiebre y rash cutáneo, sin compromiso de mucosas, con respuesta no favorable al manejo con esteroide, requiriendo Inmunoglobulina IV. Semanas después del inicio de los síntomas y evolución estable presenta insuficiencia renal aguda que requirió terapia de reemplazo renal. Se descartaron otras patologías subyacentes de índole autoinmune. Hubo recuperación de azoados y normalización de los demás paraclínicos el día 40 de la enfermedad. El paciente continúa asintomático, 4 meses después, con tratamiento con esteroide oral, en descenso lento y gradual. Se debe considerar la evaluación permanente de las pruebas de función renal en los pacientes que presenten Síndrome de DRESS, por su asociación con Nefritis intersticial aguda y complicaciones relacionadas.
Tax Non-Audit Services and Client Income Tax Estimation Error
Authors: Choudhary Preeti , Koester Allison , Pawlewicz Robert 
Published: August 2021

SUMMARY
The provision of non-audit services (NAS) to audit clients can generate knowledge spillovers that enhance auditors' judgments or self-review and self-interest threats that impair auditors' independence. Prior research finds mixed evidence of a relation between tax NAS and clients' (actual and potential) material GAAP violations in accounting for income taxes. As auditors are likely to avoid material GAAP violations, we re-examine this issue using a measure that reflects immaterial or within-GAAP estimation error in clients' income tax expense. We find that greater amounts of tax NAS are associated with greater income tax estimation error, consistent with tax NAS threating auditors' independence. The association is partially offset by auditor expertise and concentrated in engagements where auditors face both self-review and self-interest threats. Our findings inform the ongoing policy debate regarding whether accounting firms should provide tax NAS to their audit clients.
Data Availability: Data are publicly available from the sources indicated in the text.
JEL Classifications: M41; M44; M49.
Game Changer: Can Modifications to Audit Firm Communication Improve Auditors' Actions in Response to Heightened Fraud Risk?
Authors: Austin Ashley A. , Carpenter Tina D. 
Published: August 2021

SUMMARY
Regulators express concern over auditors' failure to respond to fraud risks. Audit firms communicate the importance of remaining skeptical and alert for fraud, but busy auditors give these messages insufficient attention. Building on psychology theory, we develop an innovative intervention designed to improve audit firm communication by incorporating game-like elements. We expect game-like elements to pique auditors' interest, deepen their cognitive processing, and enhance their awareness of important fraud concepts, making them more alert for fraud. We experimentally demonstrate that the intervention improves auditors' awareness of important fraud concepts, and these benefits persist to improve auditors' fraud detection actions. Importantly, auditors receiving communication that simulates current practice fail to respond to heightened fraud risk, confirming regulators' concerns. In additional analyses, a model supports our intervention promoting deeper processing of the communication, enabling auditors' subsequent recognition of heightened fraud risk and effective actions. Thus, our results contribute to theory and practice.
On Controlling for Misstatement Risk
Authors: Moon James R. , Shipman Jonathan E. , Swanquist Quinn T. , Whited Robert L. 
Published: August 2021

SUMMARY
Ex ante misstatement risk confounds most settings relying on misstatements as a measure of audit quality, but researchers continue to debate how to effectively control for this construct. In this study, we consider a recent approach that involves controlling for prior period misstatements (“Lagged Misstatements”). Using a controlled simulation and a basic archival analysis, we show that a lagged misstatement control can significantly bias coefficient estimates. We demonstrate this bias using audit fees as a variable of interest but also show the same issue manifests for other measures that respond to the restatement of misstated financial statements (i.e., internal control material weaknesses and auditor changes). We conclude by discussing alternative approaches for controlling for ex ante misstatement risk and providing guidance for future research.
Data Availability: All data used are publicly available from sources cited in the text.
JEL Classifications: M40; M41; M42.
Pengaruh Sarana dan Prasarana Wisata Terhadap Kepuasan Wisatawan di Pulau Pasumpahan Padang
Authors: Ryanda Rahmad , Wulansari Nidia 
Published: August 2021

Penelitian ini dilatar belakangi oleh kepuasan wisatawan yang berkunjung di pulau pasumpahan padang. Tujuan dari penelitian ini mendeskripsikan kepuasan wisatawan di pulau pasumpahan. Judul dari penelitian ini adalah Pengaruh sarana dan prasara wisata terhadap kepuasan wisatawan di pulau pasumpahan. Teknik yang dipakai komunikasi tidak langsung dengan cara menyebar kuosioner yang diberikan kepada wisatawan lalu di olah menggunakan program spss. Penelitian ini masuk kepada penelitian Deskriptif Kuantitatif dengan memakai metode asosiatif kausal. Dalam penelitian ini populasinya adalah wisatawan yang pernah berkunjung ke pulau pasumpahan Padang, dengan sampel sebanyak 87 orang dengan teknik pengambilan sampel non problability sampling dengan penentuan sampel berdasarkan kriteria umur di atas 20 tahun. Data yang digunakan pada penelitian ini data primer dan data sekunder. Berdasarkan hasil penelitian yang telah dilakukan dengan penyebaran angket menggunakan metode skala likert. Data ini dianalisis menggunakan program SPSS versi 22.00. Hasil dari penelitian ini menyatakan sarana dan prasarana berada pada kategori kurang baik (56%), kepuasan wisatawan berada pada kategori kurang puas (77%) dan nilai R square 0,330 hasil uji hipotesis diperoleh nilai F hitung 41,775 dengan sig 0,000 0,05 dan diperoleh nilai t sebesar 6,463 dengan taraf sig 0,000 0,05 mengartikan variabel X dapat mempengaruhi variabel Y secara signifikan. Maka variabel sarana dan prasarana X mempengaruhi variabel kepuasan Y. Diperoleh koefisien regresi sebesar 0,631 dengan signifikansi 0,000 0,05 yang berarti setiap peningkatan 1 satuan sarana prasarana dapat meningkatkan 0,631 satuan kepuasan . Berdasarkan dari hasi penelitian , sarana dan prasarana mempengaruhi kepuasan wisatawan di pulau pasumpahan.