bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disordered eating & body image of current and former athletes in a pandemic; a convergent mixed methods study - What can we learn from COVID-19 to support athletes through transitions?
Authors: Buckley Georgina Louise , Hall Linden Elizabeth , Lassemillante Annie-Claude M. , Belski Regina 
Published: June 2021

Abstract
Background
The COVID-19 pandemic has seen worsened mental health as a result of lockdowns, isolation and changes to sociocultural functioning. The postponement of the Tokyo 2020 Olympics is representative of global cancellations of sporting events, reduced facility access and support restrictions that have affected both current and former athlete’s psychological wellbeing. This study aimed to determine whether current (n = 93) and former (n = 111) athletes experienced worsened body image, relationship with food or eating disorder symptomatology during acute COVID-19 transitions.

Methods
The study was a Convergent Mixed Methods design whereby qualitative content analysis was collected and analysed simultaneously with quantitative cross-sectional data using the EAT-26 and self-report COVID-19 questions. Data were collected from April until May 2020 to capture data pertaining to transitions related to the pandemic and included individuals across 41 different individual and team sports from club to international competition levels.

Results
There was a surge in disordered eating in current and former athletes as a result of the early COVID-19 response. Eating disorders were suggested to occur in 21.1% of participants (18% current athletes n = 17, 25% former athletes (n = 26). There was a significant difference between males and females (p = 0.018, r = 0.17), but interestingly no differences between groups from individual vs team sports, type of sporting category (endurance, antigravitational, ball sport, power, technical and aesthetic) or level of competition (club, state, national or international). 34.8% (n = 69) self-reported worsened body image and 32.8% (n = 65) self-reported a worsened food relationship directly from COVID-19. Qualitative analysis indicated that disordered eating occurred predominantly in the form of body preoccupation, inhibitory food control, fear of body composition changes and binge eating.

Conclusions
This study indicates that transitions in COVID-19 have worsened food-body relationships in current and former athletes and must be treated as an at-risk time for eating disorder development. We suggest that resources are allocated appropriately to assist athletes to foster psychologically positive food and body relationships through COVID-19 transitions. This study makes practice suggestions in supporting athletes to manage control, seek support, adapt and accept change and promote connection and variety through athletic transitions.
Microwave ablation eustachian tuboplasty: A preliminary investigation with long-term follow-up
Authors: Lou Zhengcai , Lou Zihan , Sun Junzhi , Chen Zhengnong , Yin Shankai 
Published: June 2021

Objectives This study was performed to evaluate the efficacy of microwave ablation (MWA) eustachian tuboplasty for the treatment of patients with retracted tympanic membrane (TM) due to eustachian tube dysfunction (ETD). Methods This was a prospective study of 20 patients with ETD (middle ear atelectasis) who underwent MWA eustachian tuboplasty. Outcomes included the ability to perform a Valsalva maneuver, audiometry results, tympanometry results, ETD Questionnaire (ETDQ-7) score, and TM status. Results Eighteen patients (18 ears) were included in this study. There were statistically and clinically significant improvements in the mean ETDQ-7 score at 6 months postoperatively (change in mean score of 16.7 ± 3.6, P < 0.001) and at 30 months postoperatively (change in mean score of 18.9 ± 2.9, P < 0.001). Type A tympanogram was obtained in 27.8% of patients (5/18) at 6 months postoperatively, and in 77.7% at 30 months postoperatively. A Valsalva maneuver was possible in 72.2% of patients at 6 months postoperatively and in 88.9% of patients at 30 months postoperatively. In addition, the ears of 13 patients (72.2%) showed both normal tympanograms and TM at 30 months postoperatively. Interestingly, 38.5% of patients (5/13) exhibited complete sclerosis of the pars tensa. None of the patients experienced severe MWA-related complications during follow-up. Conclusions MWA eustachian tuboplasty is a feasible alternative to conventional tuboplasty, and can improve subjective and objective outcomes in patients with ETD for up to 30 months following treatment. In addition, this study showed that the extent of sclerotic plaque increased over time, whereas the extents of atrophy and tensa retraction decreased following tuboplasty in most patients. Graphical Abstract
Real-time spatio-temporal event detection on geotagged social media
Authors: George Yasmeen , Karunasekera Shanika , Harwood Aaron , Lim Kwan Hui 
Published: June 2021

AbstractA key challenge in mining social media data streams is to identify events which are actively discussed by a group of people in a specific local or global area. Such events are useful for early warning for accident, protest, election or breaking news. However, neither the list of events nor the resolution of both event time and space is fixed or known beforehand. In this work, we propose an online spatio-temporal event detection system using social media that is able to detect events at different time and space resolutions. First, to address the challenge related to the unknown spatial resolution of events, a quad-tree method is exploited in order to split the geographical space into multiscale regions based on the density of social media data. Then, a statistical unsupervised approach is performed that involves Poisson distribution and a smoothing method for highlighting regions with unexpected density of social posts. Further, event duration is precisely estimated by merging events happening in the same region at consecutive time intervals. A post processing stage is introduced to filter out events that are spam, fake or wrong. Finally, we incorporate simple semantics by using social media entities to assess the integrity, and accuracy of detected events. The proposed method is evaluated using different social media datasets: Twitter and Flickr for different cities: Melbourne, London, Paris and New York. To verify the effectiveness of the proposed method, we compare our results with two baseline algorithms based on fixed split of geographical space and clustering method. For performance evaluation, we manually compute recall and precision. We also propose a new quality measure named strength index, which automatically measures how accurate the reported event is.
Mesoporous activated carbon yielded from pre-leached cassava peels
Authors: Kayiwa R. , Kasedde H. , Lubwama M. , Kirabira J. B. 
Published: June 2021

AbstractThe search for alternatives to fossil-based commercial activated carbon (AC) continues to reveal new eco-friendly potential precursors, among which is agricultural waste. The key research aspect in all these endeavors is empirical ascertainment of the core properties of the resultant AC to suit a particular purpose. These properties include: yield, surface area, pore volume, and the active surface groups. It is therefore pertinent to have process conditions controlled and tailored towards these properties for the required resultant AC. Pre-leaching cassava peels with NaOH followed by KOH activation and carbonization at holding temperatures (780 °C) above the melting point of K (760 °C) yielded mesoporous activated carbon with the highest surface area ever reported for cassava peel-based AC. The carbonization temperatures were between 480 and 780 °C in an activation–carbonization stepwise process using KOH as the activator at a KOH:peel ratio of 5:2 (mass basis). A 42% maximum yield of AC was realized along with a total pore volume of 0.756 cm3g−1 and BET surface area of 1684 m2g−1. The AC was dominantly microporous for carbonization temperatures below 780 °C, but a remarkable increase in mesopore volume (0.471 cm3g−1) relative to the micropore volume (0.281 cm3g−1) was observed at 780 °C. The Fourier transform infrared (FTIR) spectroscopy for the pre-treated cassava peels showed distortion in the C–H bonding depicting possible elaboration of more lignin from cellulose disruption by NaOH. A carboxylate stretch was also observed owing to the reaction of Na+ ions with the carboxyl group in the raw peels. FTIR showed possible absorption bands for the AC between 1425 and 1712 cm−1 wave numbers. Besides the botanical qualities of the cassava peel genotype used, pre-leaching the peels and also increasing holding activation temperature above the boiling point of potassium enabled the modified process of producing highly porous AC from cassava peel. The scanning electron microscope (SEM) and transmission electron microscope (TEM) imaging showed well-developed hexagonal pores in the resultant AC and intercalated K profile in the carbon matrices, respectively.
Collection, curation and the use of humidification to restore nest shape in a research museum bird nest collection
Authors: Haff Tonya M. , Tees Natalie , Wood Kathryn , Cawsey E. Margaret , Joseph Leo , Holleley Clare E. 
Published: June 2021

AbstractBackgroundBird nests are an important part of avian ecology. They are a powerful tool for studying not only the birds that built them, but a wide array of topics ranging from parasitology, urbanisation and climate change to evolution. Despite this, bird nests tend to be underrepresented in natural history collections, a problem that should be redressed through renewed focus by collecting institutions.MethodsHere we outline the history and current best practice collection and curatorial methods for the nest collection of the Australian National Wildlife Collection (ANWC). We also describe an experiment conducted on nests in the ANWC using ultrasonic humidification to restore the shape of nests damaged by inappropriate storage.ResultsThe experiment showed that damaged nests can be successfully reshaped to close to their original dimensions. Indeed, restored nests were significantly closer to their original shape than they were prior to restoration. Thus, even nests damaged by years of neglect may be fully incorporated into active research collections. Best practice techniques include extensive note taking and photography in the field, subsampling of nests that cannot or should not be collected, appropriate field storage, metadata management, and prompt treatment upon arrival at the collection facility.ConclusionsRenewed focus on nest collections should include appropriate care and restoration of current collections, as well as expansion to redress past underrepresentation. This could include collaboration with researchers studying or monitoring avian nesting ecology, and nest collection after use in bird species that rebuild anew each nesting attempt. Modern expansion of museum nest collections will allow researchers and natural history collections to fully realise the scientific potential of these complex and beautiful specimens.
Performance of wearables and the effect of user behavior in additive manufacturing process
Authors: Kwon JuYoun , Kim Namhun 
Published: June 2021

AbstractAdditive manufacturing (AM) which can be a suitable technology to personalize wearables is ideal for adjusting the range of part performance such as mechanical properties if high performance is not required. However, the AM process parameter can impact overall durability and reliability of the part. In this instance, user behavior can play an essential role in performance of wearables through the settings of AM process parameter. This review discusses parameters of AM processes influenced by user behavior with respect to performance required to fabricate AM wearables. Many studies on AM are performed regardless of the process parameters or are limited to certain parameters. Therefore, it is necessary to examine how the main parameters considered in the AM process affect performance of wearables. The overall aims of this review are to achieve a greater understanding of each AM process parameter affecting performance of AM wearables and to provide requisites for the desired performance including the practice of sustainable user behavior in AM fabrication. It is discussed that AM wearables with various performance are fabricated when the user sets the parameters. In particular, we emphasize that it is necessary to develop a qualified procedure and to build a database of each AM machine about part performance to minimize the effect of user behavior.
Cases of generalized low-frequency shadows of tight gas reservoirs
Authors: Pu Renhai , Han Qiang , Xu Pengye 
Published: June 2021

The phenomenon that frequency decreases and amplitude increases near the bottom of a gas layer on a seismic profile is called a low-frequency shadow, but this phenomenon may not occur in all gas reservoirs. When the tight gas reservoir is thick enough, spectral decomposition data after Fourier transformation will indicate characteristics similar to those of low-frequency shadows, which we call generalized low-frequency shadows. Compared to the dominant frequency of the nongas-bearing zone spectral, the dominant frequency of a gas zone moves toward the low end of the frequency range and the low-frequency amplitude increases accordingly. By analyzing known gas reservoirs such as the Sulige and Yanchang tight sandstones in the Ordos Basin and tight carbonate rocks in the Tarim Basin, we can see that, with the visual dominant seismic frequency close to 30 Hz, the peak frequency of the gas-bearing tight sandstones and tight dolomite reservoirs will move from approximately 30 to 10–15 Hz. There is a certain correlation among the drop of the dominant frequency of a tight gas reservoir, the attenuation energy difference, and the thickness and productivity of the gas layer. Several cases indicate that nearly all tight gas layers thicker than 15 m exhibit attenuation characteristics of generalized low-frequency shadows.
Benefits and barriers to mentoring in psychiatry: a mentee's perspective
Authors: Hewson Thomas , Lagunes-Cordoba Emmeline , Tracy Derek K. 
Published: June 2021

SUMMARYMentoring is becoming increasingly recognised as a tool for supporting the junior workforce and for helping trainees to achieve their full potential. In this article we explore the benefits and barriers to mentoring in psychiatry from a trainee's perspective, and highlight differences between the role of a mentor and clinical and educational supervisor.
Investigating the causal nature of the relationship of subcortical brain volume with smoking and alcohol use
Authors: Logtenberg Emma , Overbeek Martin F. , Pasman Joëlle A. , Abdellaoui Abdel , Luijten Maartje , van Holst Ruth J. , Vink Jacqueline M. , Denys Damiaan , Medland Sarah E. , Verweij Karin J. H. , Treur Jorien L. 
Published: June 2021

BackgroundStructural variation in subcortical brain regions has been linked to substance use, including the most commonly used substances nicotine and alcohol. Pre-existing differences in subcortical brain volume may affect smoking and alcohol use, but there is also evidence that smoking and alcohol use can lead to structural changes.AimsWe assess the causal nature of the complex relationship of subcortical brain volume with smoking and alcohol use, using bi-directional Mendelian randomisation.MethodMendelian randomisation uses genetic variants predictive of a certain ‘exposure’ as instrumental variables to test causal effects on an ‘outcome’. Because of random assortment at meiosis, genetic variants should not be associated with confounders, allowing less biased causal inference. We used summary-level data of genome-wide association studies of subcortical brain volumes (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen and thalamus; n = 50 290) and smoking and alcohol use (smoking initiation, n = 848 460; cigarettes per day, n = 216 590; smoking cessation, n = 378 249; alcoholic drinks per week, n = 630 154; alcohol dependence, n = 46 568). The main analysis, inverse-variance weighted regression, was verified by a wide range of sensitivity methods.ResultsThere was strong evidence that liability to alcohol dependence decreased amygdala and hippocampal volume, and smoking more cigarettes per day decreased hippocampal volume. From subcortical brain volumes to substance use, there was no or weak evidence for causal effects.ConclusionsOur findings suggest that heavy alcohol use and smoking can causally reduce subcortical brain volume. This adds to accumulating evidence that alcohol and smoking affect the brain, and likely mental health, warranting more recognition in public health efforts.
PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Kidney in Pregnant Subjects and Fetus
Authors: Szeto Ke Xu , Le Merdy Maxime , Dupont Benjamin , Bolger Michael B. , Lukacova Viera 
Published: June 2021

AbstractThe purpose of this study was to develop a physiologically based pharmacokinetic (PBPK) model predicting the pharmacokinetics (PK) of different compounds in pregnant subjects. This model considers the differences in tissue sizes, blood flow rates, enzyme expression levels, glomerular filtration rates, plasma protein binding, and other factors affected during pregnancy in both the maternal and fetal models. The PBPKPlus™ module in GastroPlus® was used to model the PK of cefuroxime and cefazolin. For both compounds, the model was first validated against PK data in healthy non-pregnant volunteers and then applied to predict pregnant groups PK. The model accurately described the PK in both non-pregnant and pregnant groups and explained well differences in the plasma concentration due to pregnancy. The fetal plasma and amniotic fluid concentrations were also predicted reasonably well at different stages of pregnancy. This work describes the use of a PBPK approach for drug development and demonstrates the ability to predict differences in PK in pregnant subjects and fetal exposure for compounds excreted renally. The prediction for pregnant groups is also improved when the model is calibrated with postpartum or non-pregnant female group if such data are available.
Monolithic integrated waveguide device with dual functions of electro-optic modulation and optical amplification
Authors: Wang Xibin , Zhang Meiling , Jiang Minghui , Lian Tianhang , Wang Fei , Zhang Daming 
Published: June 2021

An organic polymer-based monolithic integrated waveguide device with dual functions of electro-optic (EO) modulation and optical amplification is demonstrated. In this Letter, the dual functions are achieved by employing EO polymer as the waveguide upper cladding and organic optical amplified material as the waveguide core layer. Based on this dual-functional waveguide structure, the waveguide amplifier and the EO switch are successfully designed and fabricated on a

S
i
O

2

-Si substrate. An optical gain of 5.8 dB at the wavelength of 1535 nm is obtained in the dual-functional polymer waveguide, and the EO switch based on the dual-functional polymer waveguide also presents a high-speed response time of

∼

10

n
s

.
Strukturierte Cloud Transformation in Unternehmen – Veränderungen durch Covid-19?
Authors: Brechlin Fabian 
Published: June 2021

ZusammenfassungDie Verlagerung von On-Premise Infrastruktur und Workflows in die Cloud ist schon lange kein Trend mehr, sondern eine gängige und notwendige Unternehmenspraxis. Die Covid-19 Pandemie hat vielen Unternehmen gezeigt, was für eine zentrale Rolle die Nutzung von Cloud-Services heutzutage spielt. Auch wenn sich die Cloud Transformation an sich durch die Pandemie nicht grundlegend ändert, so wird sie doch vielerorts erheblich beschleunigt oder, falls noch nicht begonnen, angestoßen. Ortsunabhängiges Arbeiten, flexible IT-Strukturen und digitale Kollaborationsmöglichkeiten sind heute oft notwendig, um einen erfolgreichen Betrieb zu gewährleisten. Die Nutzung von Cloud-Services ist dadurch fast unumgänglich geworden.Dieser Artikel basiert auf zahlreichen Praxiserfahrungen und Beobachtungen aus Cloud-Projekten bei unterschiedlichen Unternehmen. Er zeigt auf, welche Aspekte und Herausforderungen bei einer ganzheitlichen und gut geplanten Cloud Transformation berücksichtigt werden sollten. Dabei wird Bezug auf das Coronavirus als zusätzlicher Cloud-Treiber genommen. Die „Cloud Transformation Roadmap“ als Leitfaden für die Etablierung der Cloud wird vorgestellt, ebenfalls wird auf die Wichtigkeit eines ganzheitlichen Change Managements eingegangen. Es werden konkrete Empfehlungen für eine erfolgreiche Meisterung des Cloud-Einstiegs gegeben.
Evidence for in vitro and in vivo activity of the antimalarial pyronaridine against Schistosoma
Authors: Koehne Erik , Zander Nina , Rodi Miriam , Held Jana , Hoffmann Wolfgang , Zoleko-Manego Rella , Ramharter Michael , Mombo-Ngoma Ghyslain , Kremsner Peter G. , Kreidenweiss Andrea 
Published: June 2021

Background
Schistosomiasis is highly prevalent in Africa. Praziquantel is effective against adult schistosomes but leaves prepatent stages unaffected—which is a limit to patient management and elimination. Given the large-scale use of praziquantel, development of drug resistance by Schistosoma is feared. Antimalarials are promising drugs for alternative treatment strategies of Schistosoma infections. Development of drugs with activity against both malaria and schistosomiasis is particularly appealing as schistosome infections often occur concomitantly with malaria parasites in sub-Saharan Africa. Therefore, antiplasmodial compounds were progressively tested against Schistosoma in vitro, in mice, and in a clinical study.

Results
Amongst 16 drugs and 1 control tested, pyronaridine, methylene blue and 5 other antimalarials were highly active in vitro against larval stage schistosomula with a 50% inhibitory concentration below 10 μM. Both drugs were lethal to ex vivo adult worms tested at 30 μM with methylene blue also active at 10 μM. Pyronaridine treatment of mice infected with S. mansoni at the prepatent stage reduced worm burden by 82% and cured 7 out of 12 animals, however in mice adult stages remained viable. In contrast, methylene blue inhibited adult worms by 60% but cure was not achieved. In an observational pilot trial in Gabon in children, the antimalarial drug combination pyronaridine-artesunate (Pyramax) reduced S. haematobium egg excretion from 10/10 ml urine to 0/10 ml urine, and 3 out of 4 children were cured.

Conclusion
Pyronaridine and methylene blue warrant further investigation as candidates for schistosomiasis treatment. Both compounds are approved for human use and evidence for their potential as antischistosomal compounds can be obtained directly from clinical testing. Particularly, pyronaridine-artesunate, already available as an antimalarial drug, calls for further clinical evaluation.

Trial registration
ClinicalTrials.gov Identifier NCT03201770.