bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Survival in Nonsurgical Esophageal Cancer Patients Who Received Consolidation Chemotherapy Compared With Patients Who Received Concurrent Chemoradiotherapy Alone: A Systematic Review and Meta-Analysis
Authors: Xia Xiaojie , Liu Zeyuan , Qin Qin , Di Xiaoke , Zhang Zhaoyue , Sun Xinchen , Ge Xiaolin 
Published: January 2021

BackgroundConcurrent chemoradiotherapy (CCRT) is the standard treatment for nonsurgical esophageal cancer (EC). However, esophageal cancer patients receiving CCRT alone are still unsatisfactory in terms of local control and overall survival (OS) benefit. Clinicians generally add consolidation chemotherapy (CCT) after CCRT. It remains controversial whether CCT following CCRT is beneficial for esophageal cancer. We, therefore, undertook a meta-analysis to assess the need for CCT in inoperable esophageal cancer.Materials and MethodsWe combed PubMed, Embase, Cochrane Library, Web of Science, and CNKI for relevant published articles up to July 2020 that compared CCRT plus CCT to CCRT alone for patients with nonsurgical EC. Our primary endpoint was OS and progression-free survival (PFS), and the secondary endpoint was treatment toxicity. We analyzed the hazard ratio (HR) to estimate the time-to-event data and the odds ratio (OR) to compare the treatment-related effect. To assess heterogeneity, we performed the I2 test and examined publication bias using funnel plots analysis.ResultsThe 11 retrospective studies involved 2008 patients. Of these 2008 patients, 1018 received CCRT plus CCT, and 990 received CCRT. Compared to CCRT alone, CCT after CCRT did not improve disease control rate (DCR) (OR 1.66; 95% CI 0.53–5.15, p=0.384) and objective response rate (ORR) (OR 1.44; 95% CI 0.62–3.35, p=0.393). However, OS (HR 0.72; 95% CI 0.59–0.86, p &lt; 0.001) and PFS (HR 0.61; 95% CI 0.44–0.84, p=0.003) did increase. Our results show that CCT plus CCRT had a clear survival advantage over CCRT alone. The risk of treatment toxicity did not increase for EC patients who received CCT.ConclusionCCT after CCRT significantly increases OS and PFS in patients with nonsurgical EC and could provide them remarkable survival benefits. The results provide an evidence-based framework for the use of CCT after CCRT.
A Novel Ex Vivo Model of Aortic Valve Calcification. A Preliminary Report
Authors: Zabirnyk Arsenii , Perez Maria del Mar , Blasco Marc , Stensløkken Kåre-Olav , Ferrer Miguel D. , Salcedo Carolina , Vaage Jarle 
Published: January 2021

Background: No pharmacological treatment exists to prevent or stop the calcification process of aortic valves causing aortic stenosis. The aim of this study was to develop a robust model of induced calcification in whole aortic valve leaflets which could be suitable for studies of the basic mechanisms and for testing potentially inhibitory drugs.Methods: Pig hearts were obtained from a commercial abattoir. The aortic valve leaflets were dissected free and randomized between experimental groups. Whole leaflets were cultured in individual wells. Two growth media were used for cultivation: standard growth medium and an antimyofibroblastic growth medium. The latter was employed to inhibit contraction of the leaflet into a ball-like structure. Calcification was induced in the growth medium by supplementation with an osteogenic medium. Leaflets were cultivated for four weeks and medium was changed every third day. To block calcification, the inhibitor SNF472 (a formulation of the hexasodium salt of myo-inositol hexaphosphate hexasodium salt) was used at concentrations between 1 and 100 µM. After cultivation for four weeks the leaflets were snap frozen in liquid nitrogen and kept at −80 °C until blind assessment of the calcium amount in leaflets by inductively coupled plasma optical emission spectroscopy. For statistical analysis, a Kruskal–Wallis test with Dunn’s post-test was applied.Results: Osteodifferentiation with calcium accumulation was in principle absent when standard medium was used. However, when the antimyofibroblastic medium was used, a strong calcium accumulation was induced (p = 0.006 compared to controls), and this was blocked in a dose-dependent manner by the calcification inhibitor SNF472 (p = 0.008), with an EC50 of 3.3 µM.Conclusion: A model of experimentally induced calcification in cultured whole leaflets from porcine aortic valves was developed. This model can be useful for studying the basic mechanisms of valve calcification and to test pharmacological approaches to inhibit calcification.
Mental Health of Flying Cabin Crews: Depression, Anxiety, and Stress Before and During the COVID-19 Pandemic
Authors: Görlich Yvonne , Stadelmann Daniel 
Published: January 2021

Objectives: Initially, we analyzed relations between the challenging working conditions of flight attendants with symptoms of depression, anxiety and stress. As the COVID-19 pandemic plunged airlines into an unprecedented crisis, its impact on the mental health of flying cabin crews became the focus of a second survey.Methods: Flight attendants were surveyed online with DASS-21 in May 2019 (N = 105; sample 1) and April 2020 (N = 1119; sample 2), complemented with questions about working conditions (in 2019) and existential fears and fear of job loss (in 2020).Results: Sample 1 revealed that symptoms of depression, anxiety and stress highly correlated with the subjective assessment of working conditions, but not with objectifiable parameters. Sample 2 showed significant positive correlations between existential fears and fear of job loss with depression, anxiety and stress. Crew members, grounded in April 2020, showed significantly higher scores in depression and stress, while still flying individuals had more clinically relevant symptoms of anxiety. Mean value comparisons between sample 1 and 2 in DASS-21 revealed a significant increase in symptoms at the time of crisis with effect sizes of d = 0.63 for depression, d = 0.26 for anxiety, and d = 0.52 for stress. The incidence of clinically relevant symptoms among the respondents increased from 8 to 23% (depression), from 6 to 14% (anxiety), and from 8 to 24% (stress).Conclusion: The COVID-19 pandemic and associated work restrictions coincide with severe impairment of mental health of flying cabin crews, consistent with a mental health protecting function of labor.
Electronic Structure Correspondence of Singlet-Triplet Scale Separation in Strained Sr2RuO4
Authors: Acharya Swagata , Pashov Dimitar , Chachkarova Elena , Schilfgaarde Mark van , Weber Cédric 
Published: January 2021

At a temperature of roughly 1 K, Sr2RuO4 undergoes a transition from a normal Fermi liquid to a superconducting phase. Even while the former is relatively simple and well understood, the superconducting state has not even been understood after 25 years of study. More recently, it has been found that critical temperatures can be enhanced by the application of uniaxial strain, up to a critical strain, after which it falls off. In this work, we take an “instability” approach and seek divergences in susceptibilities. This provides an unbiased way to distinguish tendencies to competing ground states. We show that in the unstrained compound, the singlet and triplet instabilities of the normal Fermi liquid phase are closely spaced. Under uniaxial strain, electrons residing on all orbitals contributing to the Fermiology become more coherent, while the electrons of the Ru-dxy character become heavier, and the electrons of the Ru-dxz,yz characters become lighter. In the process, Im χ(q,ω) increases rapidly around q = (0.3,0.3,0)2π/a and q = (0.5,0.25,0)2π/a, while it gets suppressed at all other commensurate vectors, in particular at q = 0, which is essential for spin-triplet superconductivity. We observe that the magnetic anisotropy under strain drops smoothly, which is concomitant with the increment in singlet instability. Thus, the triplet superconducting instability remains the lagging instability of the system, and the singlet instability enhances under strain, leading to a large energy-scale separation between these competing instabilities. However, since this happens even without spin-orbit coupling, we believe it is primarily the enhancement in the spin fluctuation glue around quasi-anti-ferromagnetic vectors that drives the Cooper pairing instead of the magnetic anisotropy. At large strain, an instability to a spin density wave overtakes the superconducting one. The analysis relies on a high-fidelity, ab initio description of the one-particle properties and two-particle susceptibilities, based on the quasiparticle self-consistent GW approximation augmented by dynamical mean field theory. This approach is described and its high fidelity confirmed by comparing to observed one- and two-particle properties.
A Time-Frequency Measurement and Evaluation Approach for Body Channel Characteristics in Galvanic Coupling Intrabody Communication
Authors: Wei Ziliang , Wen Yangrong , Gao Yueming , Yang Mingjing , Yang Jiejie , Pun Sio Hang , Vai Mang I , Du Min 
Published: January 2021

Intrabody communication (IBC) can achieve better power efficiency and higher levels of security than other traditional wireless communication technologies. Currently, the majority of research on the body channel characteristics of galvanic coupling IBC are motionless and have only been evaluated in the frequency domain. Given the long measuring times of traditional methods, the access to dynamic variations and the simultaneous evaluation of the time-frequency domain remains a challenge for dynamic body channels such as the cardiac channel. To address this challenge, we proposed a parallel measurement methodology with a multi-tone strategy and a time-parameter processing approach to obtain a time-frequency evaluation for dynamic body channels. A group search algorithm has been performed to optimize the crest factor of multitone excitation in the time domain. To validate the proposed methods, in vivo experiments, with both dynamic and motionless conditions were measured using the traditional method and the proposed method. The results indicate that the proposed method is more time efficient (Tmeas=1 ms) with a consistent performance (ρc > 98%). Most importantly, it is capable of capturing dynamic variations in the body channel and provides a more comprehensive evaluation and richer information for the study of IBC.
Social Implications of Covid-19 Pandemic: A Brief Analysis
Authors: Riswan M 
Published: January 2021

The occurrence of Coronavirus disease (Covid-19) has become a serious worldwide health hazard. This newly invented virus or respiratory illness has affected 216 countries so far. This pandemic has caused economic, political, psychological, and cultural impacts across countries, especially among middle-class, lower-class, poor migrants who have been suffered a lot due to this pandemic worldwide. All affected countries are now battling against this tragedy and inventing proper medicine to overcome this very solemn health calamity from the world. Thus, this paper aimed to explore the social implications which occurred due to Covid-19 widespread globally. This article is an initial attempt to study and examine numerous social impacts of Covid-19 and generally interpret the ways how people are adjusting their social life during a lockdown scenario everywhere. Without previous literature contribution, this study intends to input knowledge to the existing fields. It found that people associated with the concept of social distance, lockdown, self-isolation or quarantine, sanitation, etc. In this situation, most of the communities in the world are now distorted, and it has been found that social interaction and social network were disrupted, source of income and job were dislocated, cultural practices and religious institutions are dysfunctional, and people lose their lives daily and affected seriously across global. The study will provide basic facts on social implications of Coronavirus prevalence to use as key ideas for future studies.
Prevalence of Work-Related Musculoskeletal Disorders (WMSD’s) among Bank Employees of Patiala (Preliminary Study)
Authors: Kaur Ramanjit , Pal Nat Ajay 
Published: January 2021

The purpose of this study is to examine bank employees of Government and Private sector banks for the prevalence of Work-Related Musculoskeletal Disorders (WMSD’s). For this purpose, a sample group of 30 bankers age 25-35 years were examined with the help of the Standardized Nordic Questionnaire. Statistical tools were used to evaluate the responses from the respondents. Results-56.66% of respondents reported having neck problems, 33.33% Suffers from low backrelated problems, and 20% were suffering from shoulder related problems. The study shows the high prevalence of WMSD’s in bank employees.
PENGARUH PERMAINAN TERHADAP KEMAMPUAN PASSING BAWAH BOLAVOLI PADA PESERTA DIDIK KELAS VIII MTsN 6 JOMBANG
Authors: Arnaz Arnaz 
Published: January 2021

Tujuan Penelitian ini adalah untuk mengetahui Pengaruh Permainan Terhadap Kemampuan Passing Bawah Bolavoli pada Peserta Didik Kelas VIII-B MTsN 6 Jombang. Jenis penelitian kuantitatif menggunakan model One group Pretest- Posttest Design. Sampel seluruh peserta didik kelas VIII-B MTsN 6 Jombang. Penilaian tes ini yang dinilai yaitu kemampuan Passing Bawah. Berdasarkan hasil penelitian, bahwa pada hasil penelitian ini diperoleh perhitungan hasil proses pada tabel Paired Samples T-Test diperoleh Sig (2-tailed) sebesar 0,000. Hal ini berarti nilai sig 0,000 < 0,05, maka H0 ditolak. Berdasarkan data tersebut dapat disimpulkan bahwa ada pengaruh permainan terhadap kemampuan passing bawah pada peserta didik kelas VIII-B MTsN 6 Jombang. Sesuai dengan deskriftif data dan pembahasan, maka dapat disimpulkan bahwa terdapat pengaruh yang signifikan antara permainan terhadap kemampuan passing bawah pada peserta didik kelas VIII-B MTsN 6 Jombang. maka peneliti menyarankan sebagai berikut: (1) Dengan adanya penelitian ini diharapkan dapat menjadi salah satu acuan dalam pembelajaran PJOK khususnya passing bawah dalam pembelajaran bola voli agar lebih kreatif dan inovatif. (2) Untuk penyempurnaan hasil penelitian yang lebih baik maka perlu dilakukan penelitian lagi. (3) Untuk mendapatkan hasil yang lebih baik, perlu dilakukan penelitian dengan populasi yang lebih luas terhadap sampel yang diperketat.
Pengaruh Produk, Testimoni Dan Store Atmosphere Terhadap Minat Beli Ulang Di Kafe Warunk Upnormal Gresik
Authors: Yohanes Dicky Yoeniargo  , Sutama Wisnu Dyatmika  
Published: January 2021

Dalam menunjang usaha dalam meningkatkan pembelian pada warunk upnormal di gresik maka perlu dilakukan suatu penelitian mengetahui pengaruh Pengaruh Produk, Testimoni dan Store Atmosphere secara Terhadap Minat Beli Ulang di kafe Warunk Upnormal Gresik. jumlah ada 105 orang. Hasil penelitian diharapkan dapat digunakan oleh manajemen warunk upnormal dalam upaya meningkatkan pendapatn melalui peningkatan pembelian knsumen. Hasil pengujian diperoleh hasil bahwa Produk, Testimoni dan Store Atmosphere berpengaruh positif dan signifikan terhadap Minat Beli Ulang di Kafe Warunk Upnormal Gresik.
Peningkatan Keaktifan dan Motivasi Belajar Mahasiswa melalui Pendekatan Kontekstual
Authors: Purwasih Silviana Maya , Rani Kurnia Putri  
Published: January 2021

Penelitian ini bertujuan untuk meningkatkan keaktifan dan motivasi belajar mahasiswa Program Studi Pendidikan Matematika di Universitas PGRI Adibuana pada mata kuliah Matematika Kejuruan melalui pendekatan kontekstual. Penelitian Ini merupakan Penelitian Tindakan Kelas dengan 2 siklus. Teknik pengumpulan data dilakukan melalui observasi, angket, dan dokumentasi, sedangkan teknik analisis data menggunakan reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa pendekatan kontekstual memberikan konstribusi dalam meningkatkan keaktifan dan motivasi belajar mahasiswa pada mata kuliah Matematika kejuruan. Secara klasikal, peningkatan tersebut dapat dilihat dari hasil data presentase angket keaktifan belajar mahasiswa pada siklus I mencapai 64,28%, pada siklus II meningkat sebesar 12,43% menjadi 76,71%, juga melalui presentase keseluruhan indikator motivasi belajar mahasiswa yang semula pada siklus I sebesar 62,10%, pada siklus kedua meningkat sebesar 13,74% menjadi 75,84%.
Tabel Kontingensi Untuk Mengetahui Hubungan Antara Jenis Penyakit, Jenis Kelamin, Usia, Lama Rawat dan Keadaan Keluar Pasien
Authors: Pramesti Wara 
Published: January 2021

Tabel kontingensi dapat digunakan untuk melihat hubungan dua peubah kategorik. Dari tabel kontingensi ini dapat dibuat kesimpulan apakah ada hubungan antara satu variabel dengan variabel lainnya. Data jenis penyakit, jenis kelamin, usia pasien, lama rawat dan keadaan keluar pasien diambil dari rumah sakit Siti Khadijah Sepanjang yang selanjutnya dengan menggunakan uji Chi-Square pada table Kontingensi dapat diketahui hubungan antara jenis penyakit dengan jenis kelamin, jenis penuyakit dengan usia dan jenis penyakit dengan lama rawat serta jenis penyakit dengan keadaan keluar pasien. Hasil analisis menunjukkan bahwa jenis kelamin dan usia pasien rawat inap tidak saling bebas dan keduanya saling berkaitan. Ketergantungan antara jenis penyakit dengan jenis kelamin yang paling signifikan adalah jenis penyakit GE atau diare, gastritis dan diabetes mellitus. ada jenis penyakit tertentu yang tidak signifikan hubungannya dengan usia pasien yaitu untuk jenis penyakit gastritis pada usia remaja, penyakit hypertensi pada usia dewasa, penyakit pneumonia pada usia tua dan lansia, penyakit step pada usia anak Ã‚â€“ anak dan juga penyakit FUO (demam) pada usia dewasa. Untuk hal dependensi yang paling signifikan antara lama rawat dengan keadaan keluar pasien adalah lama rawat lebih dari 2 minggu dan keluar dalam keadaan di rujuk ke rumah sakit lain dan meninggal.
ANALISIS CLUSTER PERSEPSI KONSUMEN TERHADAP PRODUK HANDPHONE UNTUK MENENTUKAN STRATEGI PROMOSI PENJUALAN di ZICOMS
Authors: Suryanita Lilia arum , Arieska Permadina kanah 
Published: January 2021

Handphone adalah salah satu perkembangan alat komunikasi dan perangkat telekomunikasi elektronik yang dapat dibawa ke mana-mana serta tidak perlu disambungkan dengan jaringan telepon menggunakan kabel. Penelitian ini bertujuan untuk mengetahui langkah–langkah analisis cluster dengan metode Complete Linkage serta mengelompokkan persepsi konsumen terhadap produk handphone dalam menentukan strategi promosi penjualan di toko Zicoms.
Langkah-langkah analisis cluster menggunakan metode Complete Linkage yaitu diawali dengan mencari dua obyek terdekat dan keduanya membentuk cluster yang pertama. Langkah selanjutnya yaitu menghitung jarak terjauh antara cluster pertama yang telah terbentuk dengan obyek lainnya, dengan demikian terbentuk matriks jarak yang baru. Proses ini akan berlanjut sampai akhirnya terbentuk cluster tunggal.
Hasil dari pengelompokkan tersebut terbentuk 4 cluster dengan cluster 1 berjumlah 9 responden, cluster 2 berjumlah 21 responden, cluster 3 berjumlah 6 responden, dan cluster 4 berjumlah 4 responden. Berdasarkan hasil pengelompokkan tersebut, dengan jumlah responden terbanyak terletak pada cluster 2 maka saran promosi diprioritaskan terhadap cluster 2
Partisipasi Masyarakat Lokal dalam Pengelolaan Kampung Lawas Maspati, Surabaya
Authors: Rahmanto Mochamad Darwin , Dwi Rohmadiani Linda 
Published: January 2021

Kampung Lawas Maspati diresmikan sebagai kampung wisata sejarah oleh Pemerintah Kota Surabaya pada tanggal 24 Januari 2016 oleh Wali Kota Surabaya dan PT. Pelindo III. Potensi wisata yang tersedia berupa bangunan kuno, kebun toga dan spot selfie. Penelitian ini bertujuan untuk menganalisis tingkat partisipasi masyarakat dalam pengelolaan kawasan wisata Kampung Lawas Maspati. Metode analisis dalam penelitian ini yaitu deskriptif kualitatif dengan teknik analisis persentase menggunakan tingkat partisipasi Arnstein. Metode pengumpulan data dengan cara dokumentasi dan kuesioner. Hasil penelitian ini menunjukan pengelolaan pariwisata di Kawasan Wisata Kampung Lawas Maspati berdasarkan hasil kuesioner 75% sudah dilakukan oleh masyarakat dan untuk masyarakat (Citizen Control).
Impacto orçamentário na compra de equipamentos de proteção individual para enfrentamento da Covid-19
Authors: Batista da Silva Karen Aline , Moratelli Giuliani Patrí­cia Maria , De Camargo Telma Aparecida , Batista da Silva Freitas Karina Alexandra , Gregório Ana Lúcia , Ramos Toso Lis Amanda 
Published: January 2021

A Covid-19 é causada pelo coronaví­rus e transmitida por contato próximo, gotí­culas e aerossóis. Para minimizar o risco de transmissão, profissionais de saúde devem fazer uso de equipamentos de proteção individual, como máscaras ou respiradores, aventais e luvas. Objetivou-se analisar a quantidade consumida destes equipamentos de proteção individual antes e durante a pandemia e também o impacto orçamentário causado para sua aquisição. Estudo retrospectivo, compreendendo os meses de janeiro/fevereiro de 2020 (antes da pandemia Covid – 19) e março/abril (durante a pandemia Covid – 19), em um hospital público. Realizado avaliação do consumo e custo de aquisição dos insumos considerados equipamento de proteção individual.Os dados foram coletados em sistema de informação próprio da instituição. Todos os itens analisados apresentaram aumento importante na quantidade utilizada e, principalmente, no valor de compra, chegando custar 525% mais caro comparado aos meses sem pandemia. O aumento dos custos estava relacionado í escassez dos produtos tanto no mercado nacional, quanto internacional. Entender os valores pagos e estabelecer controle de dispensação dos equipamentos, favorece o planejamento orçamentário.
Kualitas Air Daerah Aliran Sungai Dendeng dan Pemanfaatan Data Bagi Manajemen Lingkungan
Authors: Solo Vebronia M D 
Published: January 2021

Pemantauan kualitas air daerah aliran sungai DAS Dendeng berperan penting dalam mendukung upaya-upaya pengelolaan kualitas air dan pengendalian pencemaran air di Kota Kupang. Hal ini perlu ditunjang dengan suatu skema kerja pemantauan yang optimal. Karena itu, kajian ini bertujuan untuk mengevaluasi efektivitas pelaksanaan pemantauan kualitas air DAS Dendeng dengan (1) menilai kualitas air DAS Dendeng serta variasi-variasi spasial dan temporalnya; (2) mengidentifikasi kendala-kendala teknis dan manajemen dalam pelaksanaan pemantauan kualitas air serta implikasinya bagi perumusan manajemen dan kebijakan lingkungan. Untuk itu, data hasil pemantauan kualitas air DAS Dendeng tahun 2018-2019 dianalisa secara statistik dengan anova dua arah dan analisa klaster. Selanjutnya, dilakukan analisa SWOT (Strenghts, Weaknesses, Opportunities, and Threats) melalui wawancara dan penilaian dokumen kegiatan pemantauan kualitas air di Kota Kupang. Hasil analisa menunjukkan bahwa konsentrasi pH, TDS, TSS, dan COD terpantau masih memenuhi rentang baku mutu yang dipersyaratkan, sedangkan kadar DO, E. coli, dan Total Coliform terpantau tidak memenuhi baku mutu di beberapa lokasi dan waktu pemantauan. Kualitas air di daerah hulu dan hilir sungai berbeda signifikan. Kualitas air cenderung lebih buruk pada pemantauan bulan September dan November. Hanya saja, data kualitas air yang ada belum cukup komprehensif untuk memenuhi sejumlah kebutuhan manajemen dan kebijakan lingkungan di Kota Kupang. Hal tersebut terjadi karena kurangnya koordinasi antar bidang teknis, terbatasnya sumber daya manusia dan dukungan dana, serta komitmen dalam pemanfaatan data kualitas lingkungan. Karena itu, Pemerintah Kota Kupang perlu melakukan optimalisasi terhadap kegiatan pemantauan kualitas air.