bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current Psychometric Models and Some Uses of Technology in Educational Testing
Authors: Brennan Robert L. 
Published: December 2024

AbstractThis paper addresses some issues concerning the use of current psychometric models for current (and possibly future) technology‐based educational testing (as well as most licensure and certification testing). The intent here is to provide a relatively simple overview that addresses important issues, with little explicit intent to argue strenuously for or against the particular uses of technology discussed here.
Multisubstrate‐based system: a kinetic mechanism study of catechol‐O‐methyltransferase
Authors: Wang Fangyuan , Zhou Xianglu , Wang Haonan , Zhou Ziqiong , Yang Ling , Hu Yonghong , Qi Shenglan , Wang Ping 
Published: December 2024

Catechol‐O‐methyltransferase (COMT, EC 2.1.1.6) can transfer the methyl group from S‐adenosyl‐l‐methionine (SAM) to one of the hydroxyl groups of a catechol substrate in the presence of Mg2+. However, there is no consensus view of the kinetic mechanism of COMT involving multiple substrates. Further progress requires the development of methods for determining enzyme kinetic behavior and the binding mode of ligands to the protein. Here, we establish a multisubstrate kinetic system covering the fluorescence and mass spectrometry techniques to quantify the products in a COMT‐catalyzed reaction. The catechol substrate, 3‐BTD, can be methylated by COMT to form a single product, 3‐BTMD, with a sensitive fluorescence response and the conversion of SAM to S‐adenosyl‐l‐homocysteine (SAH) was monitored by LC–MS/MS. The kinetic assays suggested that the reaction occurred via an ordered sequential mechanism, in which SAM first bound to COMT, followed by the addition of Mg2+ and 3‐BTD. The chemical step involved a quaternary complex of COMT‐SAM‐Mg2+‐3‐BTD, followed by the ordered dissociation of 3‐BTMD, Mg2+, and SAH. In cooperation with molecular dynamics simulation, the binding of COMT to Mg2+ induced a shape change in the catechol‐binding site, which accommodated 3‐BTD binding and facilitated catalysis. These findings provide new insights into the kinetic mechanism of COMT, contributing to the development of previously undescribed functional COMT ligands.
Traditional and Contemporary Measures of Recreational Fishing Activity to Inform Sustainable Management of Blue Swimmer Crab (Portunus armatus) Fisheries in Western Australia
Authors: Smallwood Claire B. , Ryan Karina L. , Lai Eva K. M. , Tate Alissa C. 
Published: December 2024

ABSTRACTRecreational fishing is a popular activity that has many social and economic benefits. Monitoring has traditionally centred around measuring fishing effort and catch. However, contemporary measures, such as fisher demographics and behaviours, which may be linked to social and economic objectives, are now recognised as necessary to meet expectations that all aspects of resource use are considered for fisheries management. The challenge for recreational fisheries is how to regularly provide information across a growing diversity of metrics, and at a scale relevant to specific fisheries, with limited resources. The Blue Swimmer Crab (Portunus armatus) is one of the most commonly recreationally harvested species in Western Australia. This species served as a case study to explore if data from five broad‐scale phone‐diary surveys between 2011–2012 and 2020–2021 could be adapted to meet expanded information needs. Twelve discrete fisheries represented small spatial‐scale areas for fisheries management, with some variation in management arrangements (i.e., bag limits). Robust estimates of traditional and contemporary measures could be produced for three fisheries: Peel‐Harvey Estuary, Swan‐Canning Estuary and Geographe Bay. Traditional measures of participation, fishing effort, total catch and harvest from 2011–2012 to 2020–2021 were generally consistent for Swan‐Canning Estuary but decreased for Peel‐Harvey Estuary and Geographe Bay. The proportion of harvest from recreational and commercial fishing varied from mixed use (Swan‐Canning Estuary, Peel‐Harvey Estuary) to recreational only (Geographe Bay). Variation in contemporary measures was also evident, with recreational fishing largely undertaken by local residents in Swan‐Canning Estuary, while participation was more uniform between local and non‐local residents in Peel‐Harvey Estuary and Geographe Bay. We found that broad‐scale surveys could be successfully adapted to meet the growing need for information on contemporary measures to support a holistic approach to sustainable fisheries management for small spatial‐scale recreational fisheries.
Quality of Life and Oral Function in Patients With Jaw Defects Following Oral Tumour Surgery
Authors: Kosaka Takayuki , Tsuji Manami , Kida Momoyo , Fushida Shuri , Akema Suzuna , Hasegawa Daisuke , Ikebe Kazunori 
Published: December 2024

ABSTRACTObjectivesTo evaluate various oral functions in patients with jaw defects after oral tumour surgery and to clarify factors associated with their quality of life (QoL).BackgroundIn patients with jaw defects, oral function and QoL are severely impaired. No studies have evaluated oral functions of patients with jaw defects and examined their relationships with QoL.Materials and MethodsThe study participants were 72 patients (mean age: 70.7 ± 10.1 years, range 48–93 years) who underwent prosthetic treatment with a removable denture to treat a jaw defect following oral tumour surgery. Masticatory performance, maximum bite force, oral dryness, tongue pressure, and tongue‐lip motor function (oral diadochokinesis, /pa/, /ta/, /ka/ syllables) were evaluated after prosthetic treatment. The Japanese version of the EORTC QLQ‐H&N 35 was used to assess QoL. From the QoL assessment, the “Pain”, “Swallowing”, “Sense”, “Speech”, “Social eating”, and “Social contact” scales were extracted. Multiple regression analysis was conducted using each QoL scale as the dependent variable and oral functions as explanatory variables.ResultsIn the multiple regression model for “Swallowing”, the oral diadochokinesis /ta/ was a significant explanatory variable. In the model for “Sense”, tongue pressure was a significant explanatory variable. In the model for “Speech”, age was a significant explanatory variable. In the model for “Social contact”, tongue pressure was the significant explanatory variable.ConclusionIn patients with jaw defects following oral tumour surgery, lower tongue pressure is associated with poorer QoL in a wider range of ways than other oral functions are.
Effectiveness of switching strategies in CGRP monoclonal antibody therapy for migraine: A retrospective cohort study
Authors: Jaimes Alex , Gómez Andrea , Pajares Olga , Rodríguez‐Vico Jaime 
Published: December 2024

AbstractObjectiveTo evaluate the effectiveness of first switching between monoclonal antibodies (mAbs) targeting calcitonin gene–related peptide (CGRP) or its receptor in the treatment of migraine.BackgroundAlthough mAbs targeting CGRP or its receptor have emerged as a leading treatment for migraine prevention, a proportion of patients do not respond. While switching between these antibodies is a common clinical practice in such cases, the effectiveness remains a subject of study.MethodsWe conducted a retrospective cohort study at a tertiary headache center, analyzing data from clinical records of patients treated with anti‐CGRP mAbs from January 2020 to March 2024. Baseline was defined as the monthly headache days (MHDs) in the 3 months prior to the start of the second mAb. The primary endpoint was the change in MHDs at month 3 and month 6 following the switch. Additionally, we evaluated response rates in both periods. Subgroup analyses were conducted based on changes in mechanism of action. Finally, we assessed the influence of the number of doses of the first mAb and the inter‐treatment interval.ResultsOut of 1244 initially identified patients, 185 were included in the month‐3 analysis and 123 in the month‐6 evaluation. The median MHDs decreased from 27.0 (interquartile range [IQR] 16.1, 30.0; range 5.0, 30.7) at baseline to 21.0 (IQR 10.0, 30.0; range 0.0, 30.0; p < 0.001) at month 3, and to 20.0 (IQR 10.0, 30.0; range 0.0, 31.0; p < 0.001) at month 6. Subgroup analyses revealed no significant differences in MHDs between maintaining the same target or changing it (baseline: 28.0 [IQR 16.2, 30.0; range 5.0, 31.0] vs. 27.0 [IQR 6.0, 31.0; range 6.0, 31.0]; month 3: 23.0 [IQR 10.0, 30.0; range 0.0, 31.0] vs. 19.0 [IQR 11.0, 30.0; range 1.0, 31.0], p = 0.144; month 6: 24.0 [IQR 11.0, 30.0; range 0.0, 31.0] vs. 17.0 [IQR 10.0, 30.0; range 3.0, 31.0], p = 0.170). There was no association between a ≥50% reduction in MHDs and the number of previous doses of the first mAb (odds ratio [OR] 1.0; 95% confidence interval [CI] 1.0, 1.1; p = 0.189) or the inter‐treatment interval (OR 1.0; 95% CI 0.9, 1.1; p = 0.914).ConclusionSwitching between anti‐CGRP mAbs resulted in a reduction in MHDs, with no significant differences based on the mechanism of action. Factors such as the number of doses of the first mAb and the inter‐treatment interval did not appear to predict a ≥50% reduction in MHDs at month 3. Our findings support the viability of switching as an effective treatment option for patients with migraine who do not respond to initial mAb therapy.
Italian version of the Headache Disability Inventory: Cross‐cultural adaptation, validity, and reliability
Authors: Rosa Riccardo , Lionetto Filippo , Angilecchia Domenico , Carmillo Laura , Castaldo Matteo , Giovannico Giuseppe , Di Lorenzo Cherubino , Pellicciari Leonardo 
Published: December 2024

AbstractObjectiveTo translate and cross‐culturally adapt the Headache Disability Inventory (HDI) into Italian and study its reliability and validity.MethodsA total of 132 participants with primary and secondary headaches were included. The translation was performed following international guidelines with forward and back translation procedures. Structural validity, internal consistency, test–retest reliability, measurement error, and construct validity were studied. Test–retest reliability and measurement error were tested on a subsample of 32 participants.ResultsThe cross‐cultural adaptation into Italian was performed without issues. Confirmatory factor analysis supports the structural validity partially (comparative fit index = 0.963; Tucker–Lewis index = 0.959; root mean square error of approximation = 0.051; standardized root mean square residual = 0.084), showing a two‐factor structure (i.e., emotional and functional). Each subscale presented high internal consistency (α = 0.87 and 0.87 for the emotional and functional subscales, respectively), excellent and good test–retest reliability (intraclass correlation coefficient = 0.93 and 0.88 for the emotional and functional subscales, respectively), and acceptable measurement error (standard error of the measurement [SEM] = 3.6 points, minimal detectable change [MDC] = 10.0 points for the emotional subscale; SEM = 3.8 points, MDC = 10.7 points for the functional subscale). Construct validity was satisfactory for the emotional subscale and moderate for the functional subscale, as 85.7% (6/7) and 57.1% (4/7) of a priori hypotheses were met, respectively.ConclusionThe HDI was successfully translated into Italian and has acceptable psychometric properties. The Italian version of the HDI can be used in daily clinical practice and research to assess the functional and emotional impact of primary and secondary headaches. Further research should study other psychometric properties (i.e., content validity, responsiveness, and reliability in a larger sample).
Combatting Helicobacter pylori: A Focus on Nanomaterials
Authors: Wang Xuanping , Chan Xihui Felicia , Go Yuyo , Wang Yishen , Li Tingyu , Wang Gangshi 
Published: December 2024

ABSTRACTDeveloping effective non‐antibiotic antimicrobial strategies is essential for combating global antibiotic resistance, including resistance stemming from Helicobacter pylori (H. pylori) treatment. Nanomaterials offer a promising and innovative approach for non‐antibiotic anti‐H. pylori treatment strategies. This review highlights the progress made in the use of metallic and nonmetallic nanoparticles, as well as nanozymes, to directly inhibit H. pylori growth. Moreover, we summarize advances made in the direct targeting of H. pylori by nanomaterials and the stimuli‐responsive release of nanoparticles in the stomach. Additionally, we explore the recent advancements in multifunctional nanoplatforms that integrate physical methods, such as light, heat, ultrasound, and magnetism, with nanomaterials to synergistically treat H. pylori infections. Finally, we briefly address the existing challenges and future directions in this field. In summary, we highlight that with ongoing research, nanomaterials may serve as a promising treatment strategy for H. pylori eradication.
Global prevalence of excessive daytime sleepiness among nurses: A systematic review and meta‐analysis
Authors: Gu Kaini , Chen Huigang , Shi Hong , Hua Cui 
Published: December 2024

AbstractBackgroundNurses face significant risks of excessive daytime sleepiness (EDS), which adversely affects workplace safety and productivity. Yet, the extent of EDS in this workforce remains inadequately characterized.AimThe aims of this systematic review were to assess the pooled prevalence of EDS among nurses.MethodologyWe systematically searched PubMed, Embase, Scopus, and ISI Web of Science for observational studies reporting the prevalence of EDS, as measured by the Epworth Sleepiness Scale (ESS), from database inception to May 1, 2024, with no language restrictions. Study quality was evaluated using JBI's critical appraisal tool. Pooled estimates were calculated through random‐effects meta‐analysis, with subgroup and meta‐regression analyses assessing associations between EDS prevalence and study‐level factors. Linear regression modeling was used to assess time trends. This study was registered with PROSPERO (CRD42024535109).ResultsWe included 36 unique studies encompassing 2677 nurses from 20 countries. EDS occurred in 14.0%–55.6% of nurses. The results of the meta‐analysis showed a pooled prevalence of EDS of 32.2% (95% confidence interval [CI]: 28.5–36.1; I2 = 92.6). Prevalence estimate did not vary substantially in terms of study‐level data (i.e., region, country income, pre/post covid era, hospital type, proportion of female nurse, average nursing experience, or proportion of married nurses). The prevalence of EDS in nurses has remained unchanged over time.ConclusionsThis meta‐analysis identifies a high global prevalence of EDS among nurses, affecting nearly one‐third of this workforce. The findings underscore the urgent need for targeted interventions to mitigate EDS across diverse geographic and economic contexts.Implication for nursing and nursing policyThis study highlights the pervasive issue of EDS among nurses worldwide, necessitating comprehensive strategies to address this challenge across all regions, income levels, hospital settings, and demographic groups.
How Nursing Home Professionals Frame the Perspective on Residents' Safety Management: A Q‐Methodology Approach
Authors: Hong You Jung , Chang Sung Ok 
Published: December 2024

ABSTRACTAimTo identify a frame of reference for resident safety management in nursing homes.DesignQ‐methodology.MethodsThis study was conducted using Q‐methodology to identify shared perspectives about resident safety management among nursing home professionals. Data were collected from 13 May 2023, through 29 August 2023. Thirty‐four professionals, including nurses, care workers, social workers and physical therapists, classified Q‐samples into a normal distribution grid through Q‐sorting. Data analysis was performed using the PQmethod programme. Q‐factors were interpreted by integrating interview transcripts, demographic data and factor arrays that organised the analysis results.ResultsThe analysis included the Q‐sort of 33 professionals, with an average age of 46.03 years and 6.53 years of nursing home experience, after excluding one individual who did not fit any Q‐factor. Four Q factors explaining 63% of the total variance were identified: constructing individualised possible risk trajectories, utilising ingrained safety principles, creating supportive safety environments and coordinating safety principles with individual needs.ConclusionUnderstanding the diverse subjectivities of professionals can help develop strategies that promote collaboration among nursing home professionals and support preventive safety management practices.Implications for Profession and/or Patient CareThe frame of reference derived from nursing home professionals' perspectives suggests a resident‐tailored framework.ImpactThis study supports the development of interprofessional education tailored to the specific needs of nursing home settings by identifying shared perspectives among nursing home professionals. The findings highlight the need for clear guidelines to help professionals balance resident autonomy with safety and assess the impact of family involvement.Reporting MethodReporting involved qualitative and quantitative approaches, in compliance with the MMAT criteria for mixed‐method research.Patient or Public ContributionNo Patient or Public Contribution.
No support for solar radiation as a major evolutionary driver of malar stripes in falcons
Authors: Vrettos Michelle , Reynolds Chevonne , Amar Arjun 
Published: December 2024

The malar stripes of falcons (Falco spp.) are often hypothesised to function by reducing the amount of solar glare reflected into the falcon's eyes while hunting, thereby aiding foraging efficiency in bright conditions. This ‘solar glare hypothesis' is supported by intraspecific trends in peregrine falcons Falco peregrinus, in which populations inhabiting regions of higher average annual solar radiation exhibit larger and darker malar stripes on average. Here, we extend the methodological approach previously used in peregrine falcons to examine both intra‐ and interspecific relationships between solar radiation and malar stripe morphology across all extant falcon species, thereby providing a more robust test of the hypothesis that falcon malar stripes evolved as an adaptation against negative visual effects of solar glare. We obtained web‐sourced photographs of all extant falcon species, taken across each species' geographic range, and related mean breeding season solar radiation at each photograph location to the size and darkness of the birds' malar stripes, simultaneously testing for intraspecific and interspecific relationships between malar stripe characteristics and solar radiation, and including phylogeny and relevant ecological traits as covariates. We found no consistent interspecific relationship between solar radiation and malar stripe characteristics Likewise, in 38 out of 39 species, malar stripe characteristics were not positively intraspecifically related to solar radiation, with only peregrine falcons showing trends towards larger and darker malar stripes in brighter regions. Falcon malar stripes are thus unlikely to represent an adaptation against visual effects of solar glare, and their adaptive significance is more likely to be explained by crypsis or social signalling, if indeed they do represent an adaptive trait. Malar stripes may have become co‐opted for solar glare reduction in peregrine falcons due to the species' specialisation for high‐speed aerial hunting, although the intraspecific patterns observed may alternately be explained by phylogeography.Keywords: avian colouration, dark eye markings, facial plumage, falcon, malar stripe, solar glare
Parent–child relationship quality buffers the association between mothers' adverse childhood experiences and physiological synchrony
Authors: Gray Sarah A.O. , Miller Jonas G. , Glackin Erin B. , Hatch Virginia , Drury Stacy S. 
Published: December 2024

BackgroundFamily environment plays a critical role in shaping stress response systems. Concordance between mothers' and children's physiological states, specifically their Respiratory Sinus Arrhythmia (RSA), reflects dyadic co‐regulation. Negative or weakened RSA synchrony during interactions is linked to various psychosocial risks, but existing research has focused on risks in the mother or child as opposed to the dyad. This study examined the association between maternal‐child RSA synchrony and maternal ACEs, given documented associations with offspring RSA, as well as more proximal documented risks, including maternal psychopathology and children's early adversity and psychopathology. Given that sensitive parent–child relationships are a powerful source of resilience, we tested whether parent–child relationship quality buffered associations between maternal ACEs and RSA synchrony.MethodsIn a community sample of mother–child dyads experiencing high sociodemographic risk and oversampled for exposure to adversity, mothers (n = 123) reported on their ACEs (43.1% ≥4), their 3–5‐year‐old children's exposure to violence, and psychological symptoms. Dyads completed a puzzle task while EKG was recorded, from which maternal and child RSA was derived; parent–child relationship quality during interactions was coded observationally. Multilevel models examined within‐dyad mother–child RSA synchrony across the interaction and between‐dyad predictors of synchrony.ResultsParent–child relationship quality and maternal ACEs co‐contributed to offspring and dyadic physiology. Maternal ACEs predicted dampened RSA in the child and dampened RSA synchrony in the dyad, only among dyads with low observer‐rated parent–child relationship quality during the interaction. In other words, high‐quality parent–child relationship quality buffered the association between maternal ACEs and dampened offspring and dyadic physiology.ConclusionsResults suggest that mothers' early adversity may disrupt physiological regulation at both the individual child and dyadic level. High‐quality parent–child relationships mitigated this effect.
Asia‐Pacific Survey on the Management of Helicobacter pylori Infection
Authors: Otani Koji , Hang Dao Viet , Pittayanon Rapat , Liu Henry , Chuah Kee Huat , Hsiang John , Zhang Ning , Higashimori Akira , Fujiwara Yasuhiro ,   The Upper GI Focus Group of the APAGE‐ELC
Published: December 2024

ABSTRACTBackground and AimGastric cancer (GC)‐related incidence and mortality rates remain high owing to Helicobacter pylori infection in Asia, and the importance of primary and secondary prevention of GC has been well recognized. We aimed to investigate the extent of overall agreement among clinicians in the Asia‐Pacific region regarding the management of H. pylori infection.MethodsThe Upper Gastrointestinal (GI) Focus Group of the Asian Pacific Association of Gastroenterology‐Emerging Leaders Committee developed an international survey, which was distributed to 98 clinicians in the Asia‐Pacific region, compromising an online questionnaire focusing on the management of H. pylori infection.ResultsParticipants responded from Japan (15, 15.3%), Hong Kong (15, 15.3%), Thailand (33, 33.7%), Vietnam (23, 23.5%), Malaysia (4, 4.1%), Singapore (3, 3.1%), and others (5, 5.1%). The most common first‐line eradication regimen was clarithromycin (CAM) triple therapy, including proton pump inhibitor (PPI), amoxicillin (AMPC), and CAM (64.3%) for 14 days (70.4%). The most common second‐line eradication regimen was levofloxacin (LVX) triple therapy, including PPI, AMPC, and LVX (22.4%) for 14 days (67.3%). Eradication therapy was deemed necessary for all asymptomatic adults and minors (aged ≤ 17 years) currently infected with H. pylori by 81.6% and 64.3% of respondents, respectively, with 82.7% considering upper GI endoscopy for GC screening useful in the secondary prevention of GC.ConclusionThere appears to be a growing consensus among clinicians, acknowledging the necessity of eradication therapy. We anticipate that this study will establish a new benchmark in preventive medicine aimed at eradicating GC in the Asia‐Pacific region.