bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers to Climate Disaster risk Management for Public Health: Lessons from a Pilot Survey of National Public Health Representatives
Authors: Marcus Hannah , Hanna Liz 
Published: August 2021

AbstractObjectives:This study sought to examine current national disaster risk management capacities, and identify governance barriers to strengthening national preparedness for responding to public health emergencies, associated with the anticipated climate-driven intensification of natural disaster cycles.Methods:A mixed-methods online survey, assessing broader governance constraints to climate change adaptation (CCA) for public health, was distributed to representatives of national public health associations, and societies of 82 member countries under the World Federation of Public Health Associations. Specific questions relevant to disaster risk management capacities and barriers were analyzed as part of a narrowed focus on the CCA subdomain of emergency preparedness.Results:Existence of some technology, infrastructure, and/ or human resources, necessary to develop early warning and other surveillance systems for climate-related health risks was reported by 9 out of 11 responding countries. However, 7 reported persistent limitations and/ or regional discrepancies. Most significant identified barriers to strengthening emergency preparedness at the national level included governance coordination challenges, and, in the case of many developing countries, technical, medical, and human resource shortages.Conclusions:The development of new frameworks for intersectoral governance and large-scale resource mobilization will prove crucial to ongoing efforts to strengthen national climate-health resiliency and prepare for disaster-associated health threats.
Allulose in human diet: the knowns and the unknowns
Authors: Daniel Hannelore , Hauner Hans , Hornef Mathias , Clavel Thomas 
Published: August 2021

AbstractD-Allulose, also referred to as psicose, is a C3-epimer of D-fructose used as a sugar substitute in low energy products. It can be formed naturally during processing of food and drinks containing sucrose and fructose or is prepared by chemical synthesis or via enzymatic treatment with epimerases from fructose. Estimated intakes via Western style diets including sweetened beverages are below 500 mg per d but, when used as a sugar replacement, intake may reach 10 to 30 g per d depending on the food consumed. Due to its structural similarity with fructose, allulose uses the same transport and distribution pathways. But in contrast to fructose, the human genome does not encode for enzymes that are able to metabolise allulose leading to an almost complete renal excretion of the absorbed dose and near-to-zero energetic yield. However, in vitro studies have shown that certain bacteria such as Klebsiella pneumonia are able to utilise allulose as a substrate. This finding has been a subject of concern, since Klebsiella pneumoniae represents an opportunistic human pathogen. It therefore raised the question of whether a high dietary intake of allulose may cause an undesirable growth advantage for potentially harmful bacteria at mucosal sites such as the intestine or at systemic sites following invasive infection. In this brief review, we discuss the current state of science on these issues and define the research needs to better understand the fate of allulose and its metabolic and microbiological effects when ingested as a sugar substitute.
Computing with continuous objects: a uniform co-inductive approach
Authors: Spreen Dieter 
Published: August 2021

AbstractA uniform approach to computing with infinite objects like real numbers, tuples of these, compacts sets and uniformly continuous maps is presented. In the work of Berger, it was shown how to extract certified algorithms working with the signed digit representation from constructive proofs. Berger and the present author generalised this approach to complete metric spaces and showed how to deal with compact sets. Here, we unify this work and lay the foundations for doing a similar thing for the much more comprehensive class of compact Hausdorff spaces occurring in applications. The approach is of the same computational power as Weihrauch’s Type-Two Theory of Effectivity.
Paediatric cardiac rapid response systems: a survey of multicentre practices
Authors: Bavare Aarti C. , Afonso Natasha S. , Sembera Kerry A. , Buckley Jason R. , Raymond Tia T. , McKeta Angela , Costello John M. 
Published: August 2021

AbstractIntroduction:While the efficacy and guidelines for implementation of rapid response systems are well established, limited information exists about rapid response paradigms for paediatric cardiac patients despite their unique pathophysiology.Methods:With endorsement from the Paediatric Cardiac Intensive Care Society, we designed and implemented a web-based survey of paediatric cardiac and multidisciplinary ICU medical directors in the United States of America and Canada to better understand paediatric cardiac rapid response practices.Results:Sixty-five (52%) of 125 centres responded. Seventy-one per cent of centres had ∼300 non-ICU beds and 71% had dedicated cardiac ICUs. To respond to cardiac patients, dedicated cardiac rapid response teams were utilised in 29% of all centres (39% and 5% in centres with and without dedicated cardiac ICUs, respectively) [p = 0.006]. Early warning scores were utilised in 62% of centres. Only 31% reported that rapid response teams received specialised training. Transfers to ICU were higher for cardiac (73%) compared to generalised rapid response events (54%). The monitoring and reassessment of patients not transferred to ICU after the rapid response was variable. Cardiac and respiratory arrests outside the ICU were infrequent. Only 29% of centres formally appraise critical deterioration events (need for ventilation and/or inotropes post-rapid response) and 34% perform post-event debriefs.Conclusion:Paediatric cardiac rapid response practices are variable and dedicated paediatric cardiac rapid response systems are infrequent in the United States of America and Canada. Opportunity exists to delineate best practices for paediatric cardiac rapid response and standardise practices for activation, training, patient monitoring post-rapid response events, and outcomes evaluation.
Intriguing new faces of Covid-19: persisting clinical symptoms and cardiac effects in children
Authors: Erol Nurdan , Alpinar Abdullah , Erol Cigdem , Sari Erdal , Alkan Kubra 
Published: August 2021

AbstractObjective:This study was conducted to evaluate the persisting Covid-19-related symptoms of the cases included in our study and to assess their cardiac findings to determine the impact of Covid-19 on children’s cardiovascular health.Methods:In this study, 121 children between the ages of 0– and 18 with Covid-19 were evaluated based on their history, blood pressure values, and electrocardiography and echocardiography results. These findings were compared with the findings of the control group which consisted of 95 healthy cases who were in the same age range as the study group and did not have Covid-19. The results were evaluated using the statistics program, SPSS 21.Results:There was no significant difference between the study group and the control group in terms of age, weight, and body mass index. The clinical symptoms (chest and back pain, dizziness, headache, palpitation, fatigue, shortness of breath, loss of balance, coughing) of 37.2% of the cases persisted for at least 1 month after Covid-19 recovery. Statistically significant differences were found in systolic blood pressure, left ventricular ejection fraction, relative wall thickness, and tricuspid annular plane systolic excursion.Conclusion:The continuation of some cases’ clinical symptoms post-recovery indicates that long Covid infection can be observed in children. The fact that statistically significant differences were observed between the echocardiographic parameters of the study and control groups suggests that Covid-19 may have effects on the cardiovascular system. To shed light on the long Covid cases among children and the infection’s cardiac impacts, it would be beneficial to conduct more comprehensive studies on this matter.
Social inequality in food consumption between 2008 and 2019 in Brazil
Authors: Crepaldi Barbara Virginia Caixeta , Okada Letícia Martins , Rauber Fernanda , Levy Renata Bertazzi , Azeredo Catarina Machado 
Published: August 2021

Abstract

Objective:
To analyse the trend of social inequality in food consumption among Brazilians from 2008 to 2019.

Design:
Time series analyses using cross-sectional annual data from the Telephone Surveillance System (VIGITEL 2008–2019). Food consumption was evaluated through: (1) consumption of five or more portions of fruits and vegetables in ≥5 d/week; (2) consumption of beans in ≥5 d/week and (3) consumption of soft drinks or artificial juices in ≥5 d/week. Absolute inequality was assessed by the slope index of inequality (SII) and relative inequality by the concentration index (CIX). SII and CIX positive values indicate higher prevalence among more educated citizens and negative among less educated ones. Time trend was assessed by linear regression using weighted least squares.

Setting:
26 Brazilian state capitals and the Federal District.

Participants:
621 689 individuals ≥18 years.

Results:
Fruits and vegetable consumption was more prevalent among the more educated citizens, while beans were mostly consumed by the less educated, and soft drinks or artificial juices was more prevalent among individuals with intermediate education. The highest absolute inequality was found for beans (SII2019 -25·9). In 12 years, the absolute inequality increased for fruit and vegetable consumption (from SII2008 12·8 to SII2019 16·2), remained for beans (SII2008 -23·1 to SII2019 -25·9) and reduced for soft drinks or artificial juices (SII2008 8·7 to SII2019 0·4). Relative inequality was low and constant.

Conclusion:
Despite the advances reducing inequalities in soft drinks or artificial juice consumption, the increase in the social gap for adequate consumption of fruits and vegetables is troublesome.
REACTION TO THE BLACK CITY AS A CAUSE OF MODERN CONSERVATISM
Authors: Hackworth Jason 
Published: August 2021

AbstractSocial scientists in a variety of fields have long relied on economic-structuralist theories to understand the ascendance and hegemony of the modern Conservative Movement in the United States. In the materialist theory of political change (MTPC), structural crisis in the 1970s destabilized Keynesian-managerialism, and paved the way for neoliberalism. Key weaknesses of this approach include its relatively aspatial scope—comparatively less attention to the spatial variation of neoliberalism’s popularity—and its demotion of other elements of the Conservative Movement into a veritable super-structure of secondary movements. This paper offers a “racial amendment” to the MTPC, and an application to electoral geographies in the state of Ohio since 1932. This amendment synthesizes group threat theory, critical historiography, and Du Boisian theories of Whiteness to suggest that the growing influence of suburban conservatism is not reducible simply to class interest.
Diagnostics of Convective Transport Over the Tropical Western Pacific From Trajectory Analyses
Authors: Smith W. P. , Pan L. L. , Honomichl S. B. , Chelpon S. M. , Ueyama R. , Pfister L. 
Published: August 2021

AbstractThis study characterizes the representation of convective transport by a Lagrangian trajectory model driven by kinematic (pressure tendency ω) vertical velocity. Four (re)analysis wind products are used in backward trajectory calculations with the TRAJ3D model, and their representations of convective transport are analyzed. Two observation‐based diagnostics are used for the evaluation: a database of observed convective cloud tops derived from satellite measurements and a set of transit time distributions (TTDs) derived from an airborne campaign during January–February 2014 in a domain over the Tropical Western Pacific (TWP). The analysis is designed to derive trajectory‐based TTDs that can be directly evaluated using the observation‐based TTDs. The results indicate a broad consistency between two independent TTD derivations characterizing vertical transport over the TWP, with a significant portion of convective transport processes represented in trajectory experiments driven by the selected (re)analysis wind products. The convective and boundary layer source regions of upper tropospheric air parcels are shown to be consistent with the climatological flow regime within the TWP. Furthermore, contributions of convection are identified in the ω fields of the (re)analysis wind data sets, as indicated by the spatiotemporal correlation of enhanced vertical velocity and observed convection. These results demonstrate the successful application of two observation‐based diagnostics and quantify the ability for kinematic trajectory models to represent convective transport processes.
Lightning Geolocation and Flash Rates From LF Radio Observations During the RELAMPAGO Field Campaign
Authors: Antunes de Sá A. , Marshall R. , Deierling W. 
Published: August 2021

AbstractThe lightning data products generated by the low‐frequency (LF) radio lightning locating system (LLS) deployed during the Remote sensing of Electrification, Lightning, and Mesoscale/Microscale Processes with Adaptive Ground Observation (RELAMPAGO) field campaign in Argentina provide a valuable data set to research the lightning evolution and characteristics of convective storms that produce high‐impact weather. LF LLS data sets offer a practical range for mesoscale studies, allowing for the observation of lightning characteristics of storms such as mesoscale convective systems or large convective lines that travel longer distances which are not necessarily staying in range of regional VHF‐based lightning detection systems throughout their lifetime. LF LLSs also provide different information than optical space‐borne lightning detectors. Lightning measurements exclusive to LF systems include discharge peak current, lightning polarity, and lightning type classification based on the lightning‐emitted radio waveform. Furthermore, these measurements can provide additional information on flash rates (e.g., positive cloud‐to‐ground flash rate) or narrow bipolar events which may often be associated with dynamically intense convection. In this article, the geolocation and data processing of the LF data set collected during RELAMPAGO is fully described and its performance characterized, with location accuracy better than 10 km. The detection efficiency (DE) of the data set is compared to that of the Geostationary Lightning Mapper, and spatiotemporal DE losses in the LF data set are discussed. Storm case studies on November 10, 2018, highlight the strengths of the data set, which include robust flash clustering and insightful flash rate and peak current measures, while illustrating how its limitations, including DE losses, can be managed.
Polar Amplification in Idealized Climates: The Role of Ice, Moisture, and Seasons
Authors: Feldl Nicole , Merlis Timothy M. 
Published: August 2021

AbstractThe drivers of polar amplification are investigated by isolating the role of sea‐ice processes, moist energy transport, and the seasonal cycle of insolation in two models, an energy balance model and an idealized general circulation model. Compared to a simple ice‐albedo feedback (temperature‐dependent surface albedo), the addition of thermodynamic‐ice processes and the seasonal cycle of insolation profoundly affects seasonal polar warming. Climatologically limited‐extent ice in the warm season permits only small increases in absorbed solar radiation, producing weak warming, while thick, cold ice in the cold season enables a large radiatively forced response. Despite this enhanced winter warming, the annual‐mean polar amplification is modestly reduced by thermodynamic‐ice processes. When latent heat transport is disabled, polar amplification is further reduced by a factor of 1.8 across the range of ice representations, suggestive of a nearly additive warming by ice and moist‐transport processes.
Clonal myelopoiesis promotes adverse outcomes in chronic kidney disease
Authors: Dawoud Ahmed A. Z. , Gilbert Rodney D. , Tapper William J. , Cross Nicholas C. P. 
Published: August 2021

AbstractWe sought to determine the relationship between age-related clonal hematopoiesis (CH) and chronic kidney disease (CKD). CH, defined as mosaic chromosome abnormalities (mCA) and/or driver mutations was identified in 5449 (2.9%) eligible UK Biobank participants (n = 190,487 median age = 58 years). CH was negatively associated with glomerular filtration rate estimated from cystatin-C (eGFR.cys; β = −0.75, P = 2.37 × 10–4), but not with eGFR estimated from creatinine, and was specifically associated with CKD defined by eGFR.cys < 60 (OR = 1.02, P = 8.44 × 10–8). In participants without prevalent myeloid neoplasms, eGFR.cys was associated with myeloid mCA (n = 148, β = −3.36, P = 0.01) and somatic driver mutations (n = 3241, β = −1.08, P = 6.25 × 10–5) associated with myeloid neoplasia (myeloid CH), specifically mutations in CBL, TET2, JAK2, PPM1D and GNB1 but not DNMT3A or ASXL1. In participants with no history of cardiovascular disease or myeloid neoplasms, myeloid CH increased the risk of adverse outcomes in CKD (HR = 1.6, P = 0.002) compared to those without myeloid CH. Mendelian randomisation analysis provided suggestive evidence for a causal relationship between CH and CKD (P = 0.03). We conclude that CH, and specifically myeloid CH, is associated with CKD defined by eGFR.cys. Myeloid CH promotes adverse outcomes in CKD, highlighting the importance of the interaction between intrinsic and extrinsic factors to define the health risk associated with CH.
Community-based wheelchair caster failures call for improvements in quality and increased frequency of preventative maintenance
Authors: Mhatre Anand , Pearlman Jon , Schmeler Mark , Krider Benjamin , Fried John 
Published: August 2021

Abstract
Study design
Secondary data analysis of wheelchair failures and service repair logs from a network of wheelchair suppliers.

Objective
To determine the frequency of wheelchair caster failures and service repairs across wheelchair manufacturers and models and investigate the relationships between them.

Setting
Wheelchair caster failures and service repairs occurred in the community.

Methods
Reported caster failure types were classified based on the risk they pose for user injuries and wheelchair damage. Caster failures experienced by users of tilt-in-space and ultralightweight manual wheelchair models and Group 2, 3 and 4 power wheelchair models between January 2017 and October 2019 were analyzed using Chi-Square tests for independence. Correlational analysis of failures and service repairs was performed.

Results
A total of 6470 failures and 151 service repairs reported across four manufacturers and five models were analyzed. Failure types were significantly associated with manufacturers and models, respectively. Users of tilt-in-space wheelchairs, who require greater seating support, experienced twice the proportion of high-risk caster failures than the ultralightweight manual wheelchair users. Similarly, Group 3 and 4 power wheelchair users, who have complex rehabilitation needs, experienced 15-36% more high-risk failures than Group 2 users. Service repairs negatively correlated with high-risk manual wheelchair caster failures.

Conclusions
Wheelchair users who have greater seating and complex rehabilitation needs are at a higher risk for sustaining injuries and secondary health complications due to frequent caster failures. The study findings call for significant reforms in product quality and preventative maintenance practices that can reduce wheelchair failures and user consequences.
Cortisol and inflammatory biomarker levels in youths with attention deficit hyperactivity disorder (ADHD): evidence from a systematic review with meta-analysis
Authors: Chang Jane Pei-Chen , Su Kuan-Pin , Mondelli Valeria , Pariante Carmine M. 
Published: August 2021

AbstractSeveral studies reported abnormal cortisol and inflammatory biomarker levels in youths with attention deficit hyperactivity disorder (ADHD), but the results have not been conclusive. We conducted a systematic review followed by a meta-analysis of case-control studies assessing blood or saliva cortisol levels and blood levels of inflammatory biomarkers in youth with ADHD. The effect sizes (ES) were synthesized by using a random-effects model. In the 19 studies on cortisol levels (totaling n = 916 youth with ADHD and n = 947 typically developing (TD), healthy youth), youth with ADHD have lower basal cortisol levels at any time-points during the day (effect size: .68; p = 0.004) and lower cumulative levels of cortisol (ES: .39, p = .008) throughout the day than TD youth. Moreover, morning cortisol levels were lower in ADHD youth when compared with TD youth (14 studies, n = 1679, ES: .84, p = 0.003), while there is no difference for the afternoon cortisol levels (p = 0.48). The meta-analysis on inflammation biomarker was conducted on 4 studies (totaling n = 404 youth) showed that Tumour Necrosis Factor-alpha (TNF-α) was lower in ADHD when compared with TD (3 studies, n = 257 youth, p = 0.004), while no differences for Interleukin-1β(IL-1β) (p = 0.21), IL-6 (p = 0.09) and IL-10 (p = 0.77). The lower cortisol in the context of low TNF-α levels may indicate a specific pattern of biomarkers in ADHD, and further investigation is warranted.
Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling
Authors: Gu Linlin , Surolia Ranu , Larson-Casey Jennifer L. , He Chao , Davis Dana , Kang Jungsoon , Antony Veena B. , Carter A. Brent 
Published: August 2021

AbstractThe mitochondrial calcium uniporter (MCU) regulates metabolic reprogramming in lung macrophages and the progression of pulmonary fibrosis. Fibrosis progression is associated with apoptosis resistance in lung macrophages; however, the mechanism(s) by which apoptosis resistance occurs is poorly understood. Here, we found a marked increase in mitochondrial B-cell lymphoma-2 (Bcl-2) in lung macrophages from subjects with idiopathic pulmonary fibrosis (IPF). Similar findings were seen in bleomycin-injured wild-type (WT) mice, whereas Bcl-2 was markedly decreased in mice expressing a dominant-negative mitochondrial calcium uniporter (DN-MCU). Carnitine palmitoyltransferase 1a (Cpt1a), the rate-limiting enzyme for fatty acid β-oxidation, directly interacted with Bcl-2 by binding to its BH3 domain, which anchored Bcl-2 in the mitochondria to attenuate apoptosis. This interaction was dependent on Cpt1a activity. Lung macrophages from IPF subjects had a direct correlation between CPT1A and Bcl-2, whereas the absence of binding induced apoptosis. The deletion of Bcl-2 in macrophages protected mice from developing pulmonary fibrosis. Moreover, mice had resolution when Bcl-2 was deleted or was inhibited with ABT-199 after fibrosis was established. These observations implicate an interplay between macrophage fatty acid β-oxidation, apoptosis resistance, and dysregulated fibrotic remodeling.