bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exercise improves body composition, physical fitness, and blood levels of C-peptide and IGF-1 in 11- to 12-year-old boys with obesity
Authors: Ha Min-Seong , Moon Hyo Youl , Lee Minchul , Yook Jang Soo 
Published: January 2025

IntroductionExercise is vital in preventing and treating obesity. Despite its importance, the understanding of how exercise influences childhood obesity at the biochemical level is limited. In this study, we explore the effects of a 16-week exercise program (EP) on body composition, physical fitness, and the blood levels of hormones related to obesity.MethodsSixteen boys with obesity (n = 16) and seventeen boys without obesity (n = 17) took part in an EP comprising sports games and aerobic and resistance exercises. We examined alterations in body composition and physical fitness. In addition, we measured circulating hormone levels, including C-peptide, resistin, insulin-like growth factor 1 (IGF-1), and growth hormone (GH), in the blood.ResultsBody fat percentage (BFP) decreased from 37.61% at pre-EP to 29.16% at post-EP in the obese group, but not in the non-obese group. The EP decreased C-peptide (4.58 ng/mL vs. 2.96 ng/mL, p &lt; 0.001) and resistin levels (14.05 ng/mL vs. 11.06 ng/mL, p &lt; 0.001) in the obese group. After the EP, significant improvement in IGF-1 (non-obese: 265.56 ng/mL vs. 311.81 ng/mL, p &lt; 0.001; obese: 224.74 ng/mL vs. 272.89 ng/mL, p &lt; 0.001) and GH levels (non-obese: 3.91 ng/mL vs. 4.80 ng/mL, p &lt; 0.05; obese: 1.76 ng/mL vs. 2.51 ng/mL, p &lt; 0.05) were observed in both groups. Lower C-peptide levels were associated with BFP (r = 0.447, p = 0.009) and muscle mass (r = −0.385, p = 0.02), whereas enhanced IGF-1 levels correlated with increased muscle strength (r = 0.343, p = 0.05) and cardiovascular fitness (r = 0.347, p = 0.04). Multiple linear regression analysis revealed that cardiovascular fitness variability and BFP in the obese group were determined by C-peptide (β = −0.054, p &lt; 0.001) and IGF-1 levels (β = −2.936, p &lt; 0.05), respectively.DiscussionExercise may induce positive effects on improvements in body composition and physical fitness, as well as on blood levels of metabolic biochemicals such as C-peptide and IGF-1, in adolescent boys with obesity.
BrainFit: improving executive and subjective cognitive functioning in late-life mood disorders - a double-blind randomized active-controlled study evaluating the effect of online cognitive training
Authors: Oudega Mardien L. , Wagenmakers Margot J. , Palsma Tanya , Hoogendoorn Adriaan W. , Vriend Chris , van den Heuvel Odile A. , Schouws Sigfried , Dols Annemiek 
Published: January 2025

IntroductionUnipolar and bipolar mood disorders in older adults are accompanied by cognitive impairment, including executive dysfunction, with a severe impact on daily life. Up and till now, strategies to improve cognitive functioning in late-life mood disorders (LLMD) are sparse. Therefore, we aimed to assess the efficacy of adaptive, computerized cognitive training (CT) on executive and subjective cognitive functioning in LLMD.MethodsIn this double-blind, randomized controlled study we enrolled patients over the age of 50 with partly remitted LLMD. Over 8 weeks, patients participated in 24 45-minute sessions of computerized multi-domain training (CT) or an active control condition (ACC) (nonspecific cognitive activity). The primary outcome was executive functioning based on the interference score on the STROOP task (not incorporated in the training). Secondary outcomes were subjective cognitive functioning, depressive symptoms and quality of life. Outcomes were assessed before and after training (T1) and at a 3-month follow-up (T2) and analyzed with linear mixed-model analyses.ResultsThirty-eight patients were included in the study, 22 in the experimental CT and 16 in the ACC. Mean age was 67.3 years and 52.6% was female. Linear mixed-model analyses showed small within-group effect sizes, corresponding to no statistically significant improvement of executive functioning or depression severity in either group. In both groups we did observe an improvement on subjective cognitive functioning over time. From T0 to T1 the mean score of the Cognitive Functioning Questionnaire (CFQ) of the CT group decreased from 52.7 to 46.8 points (p=0.003) and the mean CFQ score of the ACC group decreased from 52.7 to 45.7 points (p&lt;0.001). This effect remained in both groups at follow-up (T2); respectively p=0.002 and p&lt;0.001.The patients in the AAC also showed an improvement of quality of life directly after the training (T1); i.e. the mean quality of life scores improved from 53 to 57 points (p=0.011), but this effect did not remain at follow-up.ConclusionsThis study shows no beneficial effect of an 8-week computerized CT on the primary outcome, i.e, executive functioning. Subjective cognitive functioning did improve in both groups, indicating that frequent cognitive training is advantageous. Future studies with more intensive training could be designed to explore this result further.Clinical trial registrationclinicaltrials.gov, identifier NCT04006756.
Economic policy uncertainty and corporate innovation-empirical evidence from Chinese pharmaceutical listed companies
Authors: Wu Zikun , Wang Su , Kuang Licong , Chen Yuwen 
Published: January 2025

IntroductionUnder the background that economic policy uncertainty tends to be normal, the innovation behavior of enterprises can cope with the cost impact brought by economic policy uncertainty.MethodsBased on the relevant data of China’s A-share pharmaceutical listed companies from 2015 to 2022, this paper empirically studied the relationship between economic policy uncertainty and firm innovation by using fixed-effect model, intermediary model, instrumental variable method and two-step method, and investigated the mechanism effects of financialization, executive compensation and government subsidies.ConclusionEconomic policy uncertainty significantly increases the innovation intensity of enterprises. Enterprises with dual management, overseas background and non-state-owned ownership will increase their innovative behavior in the face of economic policy uncertainty. Further analysis shows that economic policy uncertainty increases the innovation intensity of enterprises through three mechanisms: increasing financial transformation, obtaining government subsidies and motivating management. Increasing the innovation intensity of enterprises can deal with the risk impact caused by economic policy uncertainty, but can not deal with the negative impact of cost increase. The transformation of financialization can help enterprises cope with the operational risks and later costs caused by economic policy uncertainty.DiscussionThis study provides empirical evidence for the theoretical inference that firms respond to the impact of economic policy uncertainty and thus increase their innovation behavior.
Outbreak of Salmonella enterica subsp. enterica Serovar Napoli on a Dairy Cow Farm
Authors: Ricchi Matteo , Filippi Anita , Scaltriti Erika , Tambassi Martina , Pongolini Stefano , Bolzoni Luca , Prosperi Alice , Torreggiani Camilla , Cammi Medardo , Chiatante Alessandro , Arrigoni Norma , Massella Elisa , Luppi Andrea , Garbarino Chiara 
Published: January 2025

Salmonella is diffused worldwide, and Salmonella enterica subsp. enterica is spread worldwide with many serovars associated with the infection of domestic bovines. The most spread are S. Dublin, S. Typhimurium and S. Infantis. S. Napoli is, however very rarely reported in domestic ruminants. Here, we report an outbreak of S. Napoli on a dairy cow farm in Northern Italy (Piacenza). A total of 18 S. Napoli isolates were recovered from aborted fetuses, feces, tissues and environmental samples. Whole genome sequencing suggested that all isolates belonged to the same cluster. After the application of stringent biocontainment and biosecurity measures, no further cases were reported. However, four months after the first case, the serovar was still isolated in environmental samples, underlying the importance of adopting the correct biosecurity and biocontainment measures in order to prevent the circulation and transmission of Salmonella within the farm.
Estrategias de desempeño del Entorno Competitivo de Bróker de Seguros de Asistencia Médica en Guayaquil
Authors: Menéndez Ledesma Héctor Antonio , Zambrano Conforme Wendy Yadira , Morales Calatayud Marianela 
Published: January 2025

El trabajo que se presenta aborda el comportamiento actual de las estrategias de desempeño del bróker de seguros médicos en el entorno competitivo de la ciudad de Guayaquil, Ecuador. Se ha partido de la valoración de las tendencias regulares de los cambios que, según la literatura, se han experimentado en los últimos años en este sector de seguros a nivel mundial, identificando su consistencia con lo experimentado en el contexto de esta importante ciudad. Con el objetivo de analizar cómo el entorno competitivo determina las estrategias y el desempeño de estos bróker de seguros, en el presente artículo se realiza una triangulación metodológica de los resultados a través del análisis de métodos cualitativos y cuantitativos que han posibilitado la aplicación de entrevistas a gerentes de bróker de seguros que operan en el área de la asistencia médica, así como, los análisis PESTEL y las cinco fuerzas de Porter, que permitieron identificar las principales estrategias que implementan los bróker de seguros médicos en la ciudad de Guayaquil. Las estrategias identificadas, que son además propuestas de soluciones ante los diferentes factores que inciden en el entorno de los bróker, se agruparon en tres dimensiones fundamentales; la política, la tecnológica y la económica, considerando su peso específico en el comportamiento y la importancia que tiene que los gerentes y directivos presten especial atención a las mismas, en tanto sirven como referencia para la implementación de tácticas que aseguren el crecimiento en el sector.
Altered Atlas of Exercise-Responsive MicroRNAs Revealing miR-29a-3p Attacks Armored and Cold Tumors and Boosts Anti-B7-H3 Therapy
Authors: Mei Jie , Luo Zhiwen , Cai Yun , Wan Renwen , Qian Zhiwen , Chu Jiahui , Sun Yaying , Shi Yuxin , Jiang Ying , Zhang Yan , Yin Yongmei , Chen Shiyi 
Published: January 2025

Increasing evidence has shown that physical exercise remarkably inhibits oncogenesis and progression of numerous cancers and exercise-responsive microRNAs (miRNAs) exert a marked role in exercise-mediated tumor suppression. In this research, expression and prognostic values of exercise-responsive miRNAs were examined in breast cancer (BRCA) and further pan-cancer types. In addition, multiple independent public and in-house cohorts, in vitro assays involving multiple, macrophages, fibroblasts, and tumor cells, and in vivo models were utilized to uncover the tumor-suppressive roles of miR-29a-3p in cancers. Here, we reported that miR-29a-3p was the exercise-responsive miRNA, which was lowly expressed in tumor tissues and associated with unfavorable prognosis in BRCA. Mechanistically, miR-29a-3p targeted macrophages, fibroblasts, and tumor cells to down-regulate B7 homolog 3 (B7-H3) expression. Single-cell RNA sequencing (scRNA-seq) and cytometry by time-of-flight (CyTOF) demonstrated that miR-29a-3p attacked the armored and cold tumors, thereby shaping an immuno-hot tumor microenvironment (TME). Translationally, liposomes were developed and loaded with miR-29a-3p (lipo@miR-29a-3p), and lipo@miR-29a-3p exhibited promising antitumor effects in a mouse model with great biocompatibility. In conclusion, we uncovered that miR-29a-3p is a critical exercise-responsive miRNA, which attacked armored and cold tumors by inhibiting B7-H3 expression. Thus, miR-29a-3p restoration could be an alternative strategy for antitumor therapy.
RESISTENSI PEMBIAYAAN DAN AKSEPTASI ATAS SISA HASIL USAHA PADA KSPPS TUNAS ARTHA MANDIRI SYARIAH CABANG CIANJUR
Authors: Djuarni Wenny , Sari Three Mayang 
Published: January 2025

Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh Resistensi Pembiayaan Dan Akseptasi Atas Sisa Hasil Usaha Pada Kspps Tunas Artha Mandiri Syariah Cabang Cianjur tahun 2019-2023. Pengambilan data yang di lakukan menggunakan data sekunder, yaitu data pembiayaan, data pendapatan angsuran margin dan data Sisa Hasil Usaha (SHU) tahun 2019-2023. Metode yang digunakan adalah metode pendekatan kuantitatif. Dan tipe sampling yang dipilih adalah purposive sampling. Berdasarkan pada analisis yang telah dilakukan, diperoleh bahwa hasil perhitungan uji t pembiayaan tidak berpengaruh signifikan terhadap Sisa Hasil Usaha (SHU). Sedangkan pendapatan angsuran margin berpengaruh signifikan terhadap Sisa Hasil Usaha (SHU). Berdasarkan hasil perhitungan uji f bahwa F hitung > F tabel (8.225 > 3.159) dengan signifikan sebesar 0.001 < 0.050 menunjukan bahwa Pembiayaan dan Pendapatan angsuran margin secara simultan berpengaruh signifikan terhadap Sisa Hasil Usaha (SHU).This study aims to determine the extent of the influence of Financing Resistance and Acceptance on the Remaining Business Results at Kspps Tunas Artha Mandiri Syariah Cianjur Branch in 2019-2023. Data collection was carried out using secondary data, namely financing data, margin installment income data and data on the Remaining Business Results (SHU) in 2019-2023. The method used is a quantitative approach method. And the type of sampling chosen is purposive sampling. Based on the analysis that has been carried out, it was obtained that the results of the financing t-test calculation did not have a significant effect on the Remaining Business Results (SHU). While the margin installment income had a significant effect on the Remaining Business Results (SHU). Based on the results of the f-test calculation, the calculated F> F table (8.225> 3.159) with a significance of 0.001 <0.050 indicates that Financing and Margin Installment Income simultaneously have a significant effect on the Remaining Business Results (SHU).
ANALISIS PENGETAHUAN DAN PENERAPAN K3 PADA PEKERJA DI PROYEK KONSTRUKSI (STUDI KASUS PROYEK PEMBANGUNAN RUSUN KEJATI BENGKULU)
Authors: Aslam Ifham Nur 
Published: January 2025

AbstrakPemahaman dan pelaksanaan K3 menjadi hal yang sangat penting dilakukan agar bisa menghindari kejadian yang tidak diinginkan seperti kecelakaan saat bekerja. Penyebab terjadinya kejadian yang tidak diinginkan karena yang mengerjakan proyek ini tidak melakukan pengawasan kepada setiap tenaga kerja mengenai penerapan K3 ketika melaksanakan pekerjaannya. Untuk persoalan yang terjadi pada penelitian yaitu menganalisis pemahaman mengenai prosedur K3 bagi setiap pekerja akan memberikan dampak setiap pekerjanya. Penelitian yang dilakukan bertujuan untuk melakukan analisa mengenai prosedur K3 bisa memberikan pengaruh bagi sikap para tenaga kerja dalam melakukan pembangunan Rusun Kejati Bengkulu. Metode yang dipakai yaitu jenis deskriptif, analisis frekuensi dan analisis regresi agar bisa menilai tenaga kerja yang mengerti dalam melaksanakan K3. Hasil yang diperoleh penelitian yang dilakukan dengan nilai rata-rata sebesar 4,83. Walaupun pemahaman mengenai prosedur K3 sudah bisa dipraktikan oleh tenaga kerja namun kelalaian para pekerja tidak menggunakan pelindung ketika bekerja sehingga akan memberikan dampak bagi pekerja seperti kecelakaan saat bekerja. Kecerobohan pekerja dengan meletakan alat pelindung disembarang tempat sehingga akan mempersulit petugas mencari alat tersebut. Penilaian Adjusted R2 didapatkan bahwa 0,910 menjelaskan sikap ketika melaksanakan K3 memberikan dampak pada pemahaman Keselamatan dan Kesehatan Kerja dengan hasil 91% sedangkan sisanya 9% bedampak pada faktor lain yang tidak termasuk dari penelitian ini.
RESPON PEMBERIAN NPK ORGANIK DENGAN KOMPOS DAUN JATI (Tectona grandis) TERHADAP PERTUMBUHAN TANAMAN KACANG TANAH (Arachis hypogaea L.)
Authors: Muli Ramli 
Published: January 2025

Salah satu produk hasil pertanian di indonesia adalah kacang tanah (Arachis hypogaea L.), petani umumnya memilih pupuk kimia sintetik atau anorganik sebagai sumber unsur hara bagi tanaman, hanya saja penggunaan pupuk anorganik secara berkelanjutan dan berlebihan dapat mengakibatkan tidak seimbangnya unsur hara dalam tanah. oleh karena itu, Penggunaan pupuk anorganik sebaiknya dikurangi dan meningkatkan pemberian pupuk organik. Penggunaan pupuk NPK Organik yang terdiri dari kotoran kambing, batang pisang, dan sabut kelapa. Selain itu penggunaan Kompos Daun Jati diharapkan dapat mengatasi dan menjadi solusi dari dampak negatif tersebut serta dapat meningkatkan produktivitas tanaman. Penelitian ini bertujuan untuk Untuk mengetahui pengaruh pemberian pupuk NPK Organik dan Kompos Daun Jati terhadap pertumbuhan pada tanaman kacang tanah (Arachis hypogaea L.). Penelitian ini menggnakan Rancangan Acak Kelompok (RAK) Faktorial yang terdiri dari 2 faktor dengan 3 kali ulangan. Faktor pertama adalah pemberian NPK Organik (K) dengan 4 taraf, dan Faktor kedua pemberian kompos daun jati (J) dengan 4 taraf. Faktor pertama : Pemberian NPK Organik K 0 : Kontrol atau tanpa pemberian perlakuan (0 g) K 1 : NPK Organik 200 g K 2 : NPK Organik 300 g K 3 : NPK Organik 400 g Faktor kedua : Kompos Daun Jati J0 : Kontrol atau tanpa pemberian perlakuan (0 g) J1 : Kompos Daun Jati 60 g J2 : Kompos Daun Jati 80 g J3 : Kompos Daun Jati 100 g. Hasil pengamatan menunjukkan, K tunggal Tidak berpengaruh terhadap parameter tinggi tanaman dan jumlah daun. Sedangkan pada parameter jumlah polong dan bobot basah polong memberikan pengaruh pada perlakuan K1, K2 dan K3. Adapun perlakuan J tidak berpengaruh terhadap tinggi tanaman, akan tetapi berpengaruh terhadap jumlah daun, jumlah polong, bobot basah polong dengan perlakuan J3 dan J2. Pada kombinasi K*J tidak menunjukkan pengaruh terhadap parameter tinggi tanaman, jumlah daun, jumlah polong, dan bobot basah polong.Kata kunci: Kacang tanah, Produktivitas, NPK Organik, Kompos Daun Jati
Design and Build Uno Android-Based Heart Rate Detector to Support First Aid Performance at PMI Kebumen Regency
Authors: Marsudi Tangguh Dwi Sasongko  , Rini Suwartika  
Published: January 2025

Abstract :
PMI is a humanitarian organization with legal entity status, governed by Law number 1 of 2018 concerning Red Cross activities, aimed at preventing, avoiding, and alleviating the suffering of war prisoners and disaster victims without discrimination of religion, nationality, race, skin color, group, gender, and political views. PMI also has the duty to transform its members into volunteers. This includes Disaster Preparedness and Response Volunteers, First Aid Training for Volunteers, Health Services, Community Welfare Services, and others. In community services, especially first aid services, PMI still requires more first aid equipment to support the performance of volunteers and their services. One such tool is used for emergencies, such as handling sudden cardiac arrest victims. This study developed a prototype heart rate detection device. This heart rate detection prototype is based on ATmega328. The sensor used is a Heartrate Sensor that functions to measure and detect heartbeats. Additionally, an ATmega328 Arduino Pro Mini microcontroller is used to process the incoming signals and display the heart rate per minute on an OLED screen. Based on tests conducted on 10 respondents, this heart rate detection prototype has an average relative error of 0.32% compared to the Elitech Mobile Fox 1 Pulse Oximeter.

Keywords : ATmega328, Heart Rate, Heartrate Sensor.
The Role of Ammonia in the Distribution of Volatiles in the Primordial Hydrosphere of Europa
Authors: Amsler Moulanier Alizée , Mousis Olivier , Bouquet Alexis , Glein Christopher R. 
Published: January 2025

Abstract
The presence of a hydrosphere on Europa raises questions about its habitability, and studies of its volatile inventory can provide insight into its formation process. Different scenarios suggest that Europa's volatiles could be derived from cometary ices or devolatilized building blocks. The study of post-accretion processes—in particular, the “open-ocean” phase that likely occurred before the formation of the icy crust—is crucial to distinguishing these origins, as this phase is likely to have influenced the volatile inventory. The abundance of ammonia in Europa's building blocks is also crucial for understanding the composition of its ocean and primordial atmosphere. We aim to investigate the ocean–atmosphere equilibrium during the post-accretion period by varying the ammonia fraction in the atmosphere. Our model evaluates the vapor–liquid equilibrium of water and volatiles, as well as the chemical equilibrium within the ocean, to study Europa's early hydrosphere. We explore two initial conditions: one in which Europa's hydrosphere originates from comet-like building blocks, and another in which it forms in equilibrium with a thick-and-CO2-rich atmosphere. In both scenarios, the initial ratio of accreted CO2 to NH3 determines the magnitude of their partial pressures in Europa's early atmosphere. If this ratio exceeds a certain threshold (set to 10−4 in this study), the atmosphere will be CO2-rich; otherwise, it will be CO2-depleted, by multiple orders of magnitude. Overall, our work provides an initial assessment of the distribution of primordial volatiles in Europa's primitive hydrosphere and provides a baseline for interpreting data from the upcoming Europa Clipper mission.
Utility of pattern-based approach to skin biopsies in pediatric non-infectious inflammatory diseases: a review of 140 cases
Authors: Singh Neha , Mohanty Suravi , Tirumalae Rajalakshmi 
Published: January 2025

Background
Skin diseases constitute a significant burden in the pediatric age group and demand a separate evaluation from adult dermatoses as both vary in mode of presentation, prognosis, and line of treatment.

Objective
To evaluate the histopathologic spectrum of skin biopsies in pediatric noninfectious inflammatory diseases pediatric inflammatory diseases and its correlation with clinical findings.

Patients and methods
This was a retrospective study that included a total of 140 skin biopsies of noninfectious inflammatory dermatoses in children aged up to 18 years. The clinical differential diagnoses were compared with histopathologic diagnoses; concordance and discordance were calculated.

Results
Of the 140 patients, histopathologic diagnoses of 109 (77.9%) patients were concordant with the clinical diagnoses, whereas 23 (16.4%) showed discordance, among which 18 (78.3%) showed major discordance, while the remaining five (21.7%) cases had minor discordance. The remaining eight (5.7%) cases were inconclusive.

Conclusion
Histopathology is still the best tool for diagnosis in the majority of pediatric inflammatory dermatoses. Effective communication between the clinician and the pathologist and thorough clinical correlation enhances the value of the skin biopsies
Melioidosis – An under-recognized dreaded disease in Southeast Asia
Authors: Muthanikkatt Anas Mohammed , Nathan Balamurugan , Uthayakumar Amaravathi , Devendiran Anandhi , Muthu Saravanan 
Published: January 2025

Abstract
Melioidosis is a disease endemic to India but often goes unrecognized, leading to considerable illness and death. We present the case of a 31-year-old man who had a fever of unknown origin, abnormal renal and liver function tests, and negative tests for dengue, typhoid, leptospirosis, and scrub typhus. Imaging revealed multiple splenic infarcts. Initially suspected to be malaria due to its prevalence in South India, further investigation uncovered pneumonia along with several liver and splenic abscesses, raising the possibility of melioidosis. Blood culture eventually identified Burkholderia pseudomallei, confirming the diagnosis. As malaria cases decline in Southeast Asia, emergency physicians should consider melioidosis in their differential diagnosis of acute febrile illnesses, especially in endemic areas. Early detection and prompt antibiotic treatment are vital for managing this often under-recognized disease with a high fatality rate. Thus, melioidosis should be considered in patients with unexplained fever in endemic regions, as early diagnosis and intervention can be life-saving.