bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value of combined detection of PCA, ANCA, ASCA, AGA and ANA in early diagnosis of Gastrointestinal Diseases
Authors: Liu Xin , Guo Deli , Li Xiaoyan , Guo Yaping , Song Wenjie 
Published: November 2021

Objectives: To investigate the positive detection rate and clinical application value of anti-parietal cell antibody (PCA), anti-neutrophil cytoplasmic antibody (ANCA), anti-Saccharomyces cerevisiae antibody (ASCA), anti-gliadin antibody (AGA) and anti-nuclear antibody (ANA) in patients visiting the Department of Gastroenterology.
Methods: From January 2015 to June 2018, 1,083 patients receiving detection of PCA and other autoantibodies were selected from the Department of Gastroenterology of Baoding First Central Hospital. The positive detection rate of autoantibodies was statistically analyzed. The enumeration data were expressed as rate or constituent ratio, and the rates were compared between groups using the x2 test.
Results: Among the 1,083 patients, the positive detection rate of ANA, ASCA, AGA, PCA and ANCA was 33.52%, 16.71%, 15.51%, 13.66% and 7.66%, respectively. The total positive detection rate was 62.8% (n = 680).
Conclusion: The population with abdominal distension, chronic abdominal pain, diarrhea and other digestive system symptoms should be timely treated with combined detection of PCA, ANCA, ASCA, AGA and ANA, which is of important clinical application value for early diagnosis of gastrointestinal diseases and prevention of missed diagnosis and misdiagnosis.
doi: https://doi.org/10.12669/pjms.38.1.4682
How to cite this:Liu X, Guo D, Li X, Guo Y, Song W. Value of combined detection of PCA, ANCA, ASCA, AGA and ANA in early diagnosis of Gastrointestinal Diseases. Pak J Med Sci. 2022;38(1):227-231. doi: https://doi.org/10.12669/pjms.38.1.4682
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The effects of telenutrition in overweight and obese adults in a nutritional center in Lima, Peru.
Authors: Castrillón Liñan Carolina , Alvarez Mayorga Jimy Henry , Lozada-Urbano Michelle 
Published: November 2021

Background: COVID-19 pandemic has been challenging for health services and systems around the world, including Peru. A viable alternative in the telemedicine field to guarantee patient nutritional care is telenutrition. Telenutrition involves the interactive use of electronic information and telecommunications technologies to implement the nutrition care process with patients at a remote location. Information regarding the experience with this methodology and its potential effect on patients’ nutritional goals, does not exist in Peru. The aim of the study was to report the effect of the evaluation type (telenutrition vs. in-person) on weight, body mass index (BMI), waist circumference (WC) and relative fat mass (RFM) in overweight and obese adult patients. Methods: This retrospective study included 100 eligible patients in a single nutritional center, from January 2019 to March 2021. Telenutrition and in-person continuous variables were compared with independent sample t-test or U Mann-Whitney test. Results: There were significant differences in weight, BMI, WC and RFM by the end of follow-up period, in both evaluation modalities. Patients on the telenutrition group had a mean decrease of 6.80 ± 4.87 cm in WC, whereas the mean difference observed for the in-person group was 6.74 ± 4.55 cm. There were no significant differences in the changes of any anthropometric parameters when comparing both systems. Reductions were observed in weight (5.93 ± 3.88 kg vs. 4.92 ± 3.29 kg), BMI (2.23 ± 1.39 kg/ m2 vs. 1.83 ± 1.23 kg/ m2), WC (6.80 ± 4.87 cm vs. 6.74 ± 4.55 cm) and RFM (2.43 ± 1.78 vs. 2.63 ± 1.73) in telenutrition and in-person evaluation, respectively by the end of the follow-up period. Conclusions: Telenutrition may be regarded as an alternative to in-person evaluation offering anthropometric changes and nutritional goals similar to those reported through the in-person modality, in overweight and obese adult people.
Using Machine Learning Methods Incorporating Individual Reader Annotations to Classify Paediatric Chest Radiographs in Epidemiological Studies
Authors: Mwaniki Paul , Kamanu Timothy , Akech Samuel , Eijkemans M. J. C 
Published: November 2021

Introduction: Epidemiological studies that involve interpretation of chest radiographs (CXRs) suffer from inter-reader and intra-reader variability. Inter-reader and intra-reader variability hinder comparison of results from different studies or centres, which negatively affects efforts to track the burden of chest diseases or evaluate the efficacy of interventions such as vaccines. This study explores machine learning models that could standardize interpretation of CXR across studies and the utility of incorporating individual reader annotations when training models using CXR data sets annotated by multiple readers.Methods: Convolutional neural networks were used to classify CXRs from seven low to middle-income countries into five categories according to the World Health Organization's standardized methodology for interpreting paediatric CXRs. We compared models trained to predict the final/aggregate classification with models trained to predict how each reader would classify an image and then aggregate predictions for all readers using unweighted mean.Results: Incorporating individual reader's annotations during model training improved classification accuracy by 3.4% (multi-class accuracy 61% vs 59%). Model accuracy was higher for children above 12 months of age (68% vs 58%). The accuracy of the models in different countries ranged between 45% and 71%.Conclusions: Machine learning models can annotate CXRs in epidemiological studies reducing inter-reader and intra-reader variability. In addition, incorporating individual reader annotations can improve the performance of machine learning models trained using CXRs annotated by multiple readers.
Die Reichstagsteilnahme des livländischen Deutschordenszweiges und seine Beziehungen mit dem deutschen Zweig (ca. 1520‒1560)
Authors: Maasing Madis 
Published: November 2021

The participation of the Livonian branch of the Teutonic Order at the Imperial Diets and its relations with the German branch (from the 1520s to the 1550s)

This article discusses the relations of Livonian branch of the Teutonic Order with the German branch from the secularization of Prussia (1525) to the beginning of the Livonian War (1558), and concentrates on the topics that were connected with the participation of the Order at the Imperial Diet of the Holy Roman Empire. Before the aforementioned period, the branches had very few direct connections, and relations of the Livonian branch with the Empire were usually mediated by the Grand Master of the Order. After 1525, the German Master largely took over the role of a mediator, as he became the acting head of the Order and had close relations with the central Imperial institutions. The latter became increasingly important for the Livonian Master, who became an Imperial prince most probably on the 24th of December 1526. This enabled him to participate in the Imperial Diets. At the Diets, the branches represented their interests usually separately. This was partially caused by the fact that these diverged quite strongly: while the German branch aspired for the recuperation of Prussia, tried to protect the Order’s possessions from increasing intrusions of German princes, and paid the Turkish taxes to obtain support from the Emperor; the Livonian branch wanted to obtain support against the Russian threat and rivals inside Livonia, while also trying to avoid paying Imperial taxes. Additionally, the Duke of Prussia was the neighbour of Livonia with whom the Livonian branch usually tried to maintain normal relations. Nevertheless, the branches communicated quite actively during the Diets and supported each other, at least in a rhetorical capacity. Additionally, Livonian envoys normally went firstly to the German Master for consultations and headed to the Diets only thereafter. Thus, the communication was quite vivid, but did not leave many marks to the official documentation, as especially the Livonian branch preferred to represent itself as a separate and independent member of the Empire in front of the Imperial Estates.
Die Benennung und Bestimmung der Räume im südlichen Repräsentativteil des Geschosses des zweiten „Hochmeisterpalastes“ auf der Marienburg im Mittelalter im Lichte der Schriftquellen
Authors: Jóźwiak Sławomir , Trupinda Janusz 
Published: November 2021

Nomenclature and intended use of the rooms of the southern (representative) part of the upper floor of the “palace” of Grand Masters in the Marienburg Castle in the Middle Ages on the basis of written sources

The analyses carried out in this article concerning the southern part of the upper floor of the new (second) “palace” of the Teutonic Order’s superiors in the late Middle Ages allow to formulate several important conclusions. First of all, the building certainly existed before 11 September 1392, but it cannot be ruled out that it was erected at the beginning of the 1370s. In the fifteenth-century sources, its entire southern representative part (looking from the so-called Low and High Halls) along with five rooms of different sizes located there, were referred to as the “Summer (or, less often, Winter) chamber (gemach)”.
This name comes from the most characteristic interiors located there: the “Summer Refectory” / “Great Summer Hall” in the western part and the Winter Refectory in the central part. The thorough analysis of medieval written sources carried out in this article allows for the formulation of the thesis that the chamber located in the easternmost part of the southern part of the “palace”, supported by two columns, should be identified as the “Minor Summer Hall” (aula minor estivalis), which was recorded in the transumpt of 14 May 1456. Thus, all the suggestions concerning this interior and its supposed intended use in the discussed period, hitherto put forward by the researchers who have so far formulated their conclusions in isolation from the written accounts of the period, should be rejected.
This name comes from the most characteristic interiors located there: the "Summer Refectory" / "Great Summer Hall" in the western part and the Winter Refectory in the central part. The thorough analysis of medieval written sources carried out in this article allowed for the formulation of the thesis that the chamber located in the easternmost part of the southern part of the "palace", supported by two columns, should be identified as the "Minor Summer Hall" (aula minor estivalis), which was recorded in the transumpt of 14 May 1456. Thus, all the suggestions concerning this interior and its supposed intended use in the discussed period, hitherto put forward by the researchers who have so far formulated their conclusions in isolation from the written accounts of the period, should be rejected.
Social Representation of Non-Academic Work in Mexico in the Light of Cultural Artefacts
Authors: Clement Ute , Fuentes Paola García , Gold Stefan , Hunink Claudia , Raesfeld Lydia 
Published: November 2021

Context: Technical and Vocational Education and Training (TVET) has attracted increasing interest in recent years due to its potential to address productivity and equity challenges, such as better employment prospects, as outlined in the United Nations Sustainable Development Goals (SDGs). Despite the potential of such programmes, the enrolment rate in vocational training at upper secondary level in Mexico is 38.2%, i.e. below the Organisation for Economic Cooperation and Development (OECD) average of 45.7%. This raises the question of possible reasons for the low enrolment rate. Approach: Based on the assumption that attitudes towards non-academic work are culturally anchored in Mexican society, which also shapes the educational and career aspirations of younger generations, the project named Cultural Practice of Non-academic Work in Mexico (KuPraMex), funded by the German Federal Ministry of Education and Research (BMBF), investigates social representations of non-academic work in Mexico. This is done through the analysis of artefacts such as films, murals, etc., as these are part of the tangible culture of a society. As materialised products of human activities or cultural practices, artefacts can be understood as objectifications of social relations and conditions. Therefore, in this context, it is assumed that through the analysis of cultural artefacts, a deeper understanding of how non-academic work is thought, felt, and valued in Mexican society will emerge.Findings: It has been found that the topic on non-academic work is often associated with informality. Moreover, the representations and narratives in cultural artefacts often show that non-academic work, apart from office work, is physically challenging but cognitively undemanding. In terms of access to a company, social networks seem to have enormous relevance. Hierarchies seem rigid and opportunities for promotion limited. However, narratives with more positive attributions regarding non-academic work can also be identified, which state that young people experience a habitus transformation through work. Conclusion: Nevertheless, non-academic work in Mexico seems to lack prestige, which may affect young people's educational and career aspirations and choices. This could mean that those who can afford it prefer to pursue a career in tertiary education rather than opt for a TVET programme. At the macro level, the mentioned lack of prestige could hamper attempts to offer such programmes.
Polarization-controlled chirped guided-mode resonance filter incorporating a hybrid splay–twist liquid crystal
Authors: Chang Li-Min , Yin Chuan Ci , Guo Duan-Yi , Huang Chia-Wei , Lin Tsung-Hsien , Wang Chun-Ta , Hung Yung-Jr 
Published: November 2021

This work develops a tunable chirped guided-mode resonant (GMR) filter that has a hybrid splay–twist (HST) liquid crystal as a cladding layer. The GMR filter is a color reflector that strongly reflects light at the resonance wavelength, and its chirped grating structure supports tuning of the resonance peak over a wavelength range of over 50 nm. The HST-LC configuration serves as an achromatic polarization rotator that can rotate the axis of polarization of linearly polarized light by providing effective twist angles in the LC layer under an applied voltage. The HST-LC is used to change the direction of the polarization axis of the light that is reflected by the GMR filter; continuous angles of rotation of

∼

90

∘

are achieved and the linear polarization is retained under applied voltages. The proposed filter enables an ultrabroadband polarization rotation and still maintains a high degree of linear polarization, which allows more degrees of freedom in spectral and polarization controls.
Development and validation of a self-reported questionnaire to assess occupational balance in parents of preterm infants
Authors: Dür Mona , Röschel Anna , Oberleitner-Leeb Christiane , Herrmanns Verena , Pichler-Stachl Elisabeth , Mattner Barbara , Pernter Silvia-Desiree , Wald Martin , Urlesberger Berndt , Kurz Herbert , Frischer Thomas , Zwiauer Karl , Berger Angelika 
Published: November 2021

Background
Parents’ meaningful activities (occupations) and occupational balance are relevant to neonatal care. Valid and reliable self-reported measurement instruments are needed to assess parents’ occupational balance and to evaluate occupational balance interventions in neonatal care. The aims of this study were to develop a self-reported questionnaire on occupational balance in informal caregivers (OBI-Care) and to examine its measurement properties including construct validity and internal consistency.

Methods and findings
A mixed method multicenter study design was employed. Items of the OBI-Care were created with parents of preterm infants based on qualitative research methods. Measurement properties were analyzed with quantitative data of parents of preterm infants. Construct validity was assessed by determining dimensionality, overall and item fit to a Rasch model, differential item functioning and threshold ordering. Internal consistency was examined by determining inter-item and item-total correlations, Cronbach’s alpha and Rasch’s person separation index. Fourteen parents participated in item creation. Measurement properties were explored in data of 304 parents. Twenty-two items, summarized in three subscales were compiled to the OBI-Care. Items showed an overall fit and except one item, an item fit to the Rasch model. There was no evidence of differential item functioning and all items displayed ordered thresholds. Each subscale had good values of person separation indices and Cronbach’s alpha.

Conclusions
The OBI-Care demonstrates construct validity and internal consistency and is thus a suitable measurement instrument to assess occupational balance of parents of preterm infants in neonatal care. OBI-Care is generic and can be applied in various health care settings.
Serum and aqueous humor adiponectin levels correlate with diabetic retinopathy development and progression
Authors: Yang Hyun Seung , Choi Young Je , Han Hee Yong , Kim Hak Su , Park So Hyun , Lee Kyung Sub , Lim Sang Hwa , Heo Doo Jin , Choi Sangkyung 
Published: November 2021

Purpose
To compare adiponectin (APN) levels in the serum and aqueous humor (AH) and evaluate their association with the development/progression of diabetic retinopathy (DR).

Methods
Diabetic patients with (group 3; n = 59) and without (group 2; n = 39) DR and age- and sex-matched normal subjects (group 1; n = 35) were compared. Duration of diabetes, body mass index, serum HbA1c, vascular endothelial growth factor (VEGF), APN, pentraxin 3 (PTX3), platelet derived growth factor (PDGF), intercellular adhesion molecule-1 (ICAM-1), and APN were measured and analyzed.

Results
One hundred and thirty-three participants were included. Compared to patients without diabetes, diabetic patients with DR had significantly elevated average serum APN levels (5.99±3.89 μg/ml versus 3.51±1.44 μg/ml, P = 0.002) and average AH APN levels (10.94±11.74 ng/ml versus 3.65±3.33 ng/ml, P<0.001). Serum APN was significantly correlated with AH APN (R = 0.512, P<0.001) and AH VEGF (R = 0.202, P = 0.020). The log serum APN was significantly correlated with intraocular cytokines, including log APN, log VEGF, log ICAM, log leptin, log PTX3, log PDGF, angiopoietin, C-reactive protein, and interleukins (IL)-5 and IL-10 (P<0.001, P = 0.020, P<0.001, P<0.001, P = 0.001, P<0.001, P = 0.008, P = 0.009, P<0.001, and P = 0.046, respectively). Log serum VEGF showed a significant correlation only with log AH VEGF (P = 0.001). Multivariate logistic analysis was performed to evaluate the association of DR progression and cytokine concentrations; log Serum APN and log AH APN showed good correlation with the DR progression in each model.

Conclusions
AH APN levels correlated well with DR development and progression. Serum APN could be a better marker for estimating intraocular cytokines, including both intraocular APN and VEGF concentrations in clinical field, than serum VEGF in DR patients.
Clinical manifestations, associated risk factors and treatment outcomes of Chronic Pulmonary Aspergillosis (CPA): Experiences from a tertiary care hospital in Lahore, Pakistan
Authors: Akram Waqas , Ejaz Muhammad Bilal , Mallhi Tauqeer Hussain , Syed Sulaiman Syed Azhar bin , Khan Amer Hayat 
Published: November 2021

Background
Chronic pulmonary aspergillosis (CPA) has a wide spectrum of illnesses depending on the progression of the disease and comorbid conditions. However, there is an inadequacy of investigations regarding clinical, laboratory, risk factor and prognostic data on CPA. The current study is aimed to consider the clinical manifestations, risk factors and outcomes of CPA.

Methodology
Retrospective records of all patients with a confirmed diagnosis of CPA who sought treatment at Gulab Devi Chest Hospital Lahore, Pakistan from January 2017 to December 2019 were evaluated. Data regarding demographics, clinical manifestations, comorbidities, radiographic and microbiological findings, length of hospital stay (LOS) and intensive care unit (ICU) admission was collected and analyzed to identify the factors associated with mortality. The independent factors associated with mortality were also identified by appropriate analyses.

Results
A total of 218 CPA patients were included in this study. The mean age was 45.75 ± 6.26 years. Of these, 160 (73.4%) were male, and 65 (29.8%) had diabetes. The mean LOS was 18.5 ± 10.9 days. The most common type of CPA was simple aspergilloma (56%) followed by chronic cavitary pulmonary aspergillosis (CCPA) (31.2%). About one half of the patients had a history of pulmonary tuberculosis (TB) and treatment response rates were low in patients with active TB. The overall mortality rate was 27.1%. ICU admission was required for 78 (35.8%) patients. Diabetes mellitus (DM), hematological malignancies and chronic kidney disease (CKD) were the common underlying conditions predicting a poor outcome. Mean LOS, hematological malignancies, consolidation and ICU admission were identified as the independent factors leading to mortality.

Conclusions
CPA had a significant association with TB in the majority of cases. Treatment response rates in cases with active TB were comparatively low. Cases with high mean LOS, hematological malignancies, consolidation, ICU admission, CKD and DM experienced poor outcomes. High mean LOS, hematological malignancies, consolidation and ICU stay were identified as independent risk factors for mortality. Future large prospective studies, involving aspergillus specific immunoglobulin G (IgG) antibody testing, are required for a better understanding of CPA in Pakistan.