bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of bone metabolic parameters in the diagnosis of growing pains
Authors: Li Huamei , Wang Bing , He Lin , Tao Ran , Shang Shiqiang 
Published: December 2021

AbstractObjectiveThe present study aimed to assess the diagnostic significance of serum bone metabolic parameters in children with growing pains (GPs).MethodsAll patients diagnosed with GP and healthy controls matched with age and gender were recruited at the outpatient clinic of Children's Hospital at Zhejiang University School of Medicine from August 2016 to August 2021. In all subjects, serum levels of calcium (Ca), phosphorus (P), procollagen type‐I N‐terminal (PINP), parathormone (PTH), 25‐hydroxyvitamin D (25‐(OH)D), osteocalcin (OC), N‐terminal cross‐linked telopeptides of type‐I collagen (CTX), and tartrate‐resistant acid phosphatase type 5b (TRACP5b) were investigated. The univariate analysis, multivariate logistic regression analysis, and receiver operating characteristic (ROC) curve were used to identify the bone metabolic parameters factors for diagnosing GP.ResultsWe enrolled 386 children with GP and 399 healthy controls in present study. The mean age of GP group was 5.319 years, and, primarily, the subjects were preschool‐age children. The gender ratio (male‐to‐female) was 1.27 in GP group. After adjusting for age and gender, we identified that the serum levels of Ca (p < 0.001, OR: 25.039), P (p = 0.018, OR: 2.681), PINP (p < 0.001, OR: 1.002), and PTH (p = 0.036, OR: 0.988) were independent diagnostic factors associated with GP. Area under curve (AUC) of the ROC curves was in the order: PINP (0.612) > Ca (0.599) > P (0.583) > PTH (0.541). A combination of independent diagnostic factors and multivariable logistic regression analysis provided a refined logistic regression model to improve the diagnostic potential, of which the AUC had reached 0.655.ConclusionsSerum levels of Ca, P, PINP, and PTH could be independent diagnostic factors associated with GP. The logistic model was significantly superior to bone metabolic parameters for diagnosing GP.
Hsa_circ_0000437 upregulates and promotes disease progression in rheumatic valvular heart disease
Authors: Zhu Linwen , Wang Zhifang , Sun Lebo , Zheng Dawei , Hu Bingchuan , Li Ni , Shao Guofeng 
Published: December 2021

AbstractBackgroundCurrently, the diagnosis and outcome of rheumatic valvular heart disease (RVHD) are less than ideal, and there are no accurate biomarkers. Circular RNA (circRNA) might participate in the occurrence and development of RVHD.Materials and methodsWe use circRNA microarray to filter out the target has_circ_0000437. qRT‐PCR was used to measure the expression levels of hsa_circ_0000437 in RVHD plasma samples. We assessed the diagnostic value of hsa_circ_0000437 in RVHD. Cell function in vitro experiment was to explore the effect of has_circ_0000437 on RVHD.ResultsHas_circ_0000437 is highly expressed in RVHD (p < 0.001). has_circ_0000437 has the diagnostic value in RVHD. In RVHD, hsa_circ_0000437 can promote cell proliferation and migration but inhibits its apoptosis. This may be due to the combination of has_circ_0000437 and target miRNA in the cytoplasm that affects the progress of RVHD.ConclusionsHas_circ_0000437 can promote the process of RVHD and may be a potential for the diagnosis and treatment of RVHD.
The hidden breast lesions: A case report of bilateral breast cancer
Authors: Dai Chaochao , Bao Lingyun , Tan Yanjuan , Jiang Chenxiang 
Published: December 2021

AbstractBilateral breast cancer (BBC) is rare and is associated with an unfavorable prognosis. Consequently it is crucial to improve diagnostic performance of breast cancer in the clinical setting. We report a case of BBC in a 66‐year‐old woman and describe the imaging findings, including mammography, hand‐held ultrasound, automated breast ultrasound, anatomical intelligence for breast ultrasound (AI‐breast), and magnetic resonance imaging. Only AI‐breast ultrasound successfully located the two tumors, while other imaging examinations failed to detect the tumor in the right breast.
Physiological and behavioral responses of Orchestia gammarellus (Amphipoda, Talitridae) towards trace elements contamination soil
Authors: Jelassi Raja , Khemaissia Hajer , Ayari Anas , Bohli‐Abderrazek Dhouha , Ghemari Chedliya , Raimond Maryline , Souty‐Grosset Catherine , Nasri‐Ammar Karima 
Published: December 2021

AbstractEffects of trace elements on the hepatopancreas ultrastructure and on the locomotor activity rhythm were investigated in the amphipod talitrid Orchestia gammarellus collected from Bizerte lagoon banks situated in the north of Tunisia. Animals were exposed to a series of contaminated soil with different concentrations of cadmium and zinc. The locomotor activity rhythm was studied under constant darkness. Histopathological analysis showed that the trace elements, especially the Cd, induced significant changes in the morphology and in the ultrastructural organization of hepatopancreatic cells. The significant alterations obtained were dose dependent. Concerning the behavioral response, results revealed the presence of two components whatever the experimental conditions. In addition, a great inter‐individual variability of the locomotor rhythm was observed. Patterns were in majority bimodal for the control individuals and became unimodal and multimodal when exposed under Cd and Zn, respectively. Furthermore, ultradian and circadian periods were determined. The circadian period lengthened after Zn exposure. In addition, the locomotor activity rhythm was more stable for control individuals. However, those exposed to Cd were less active.
Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles
Authors: Witwer Kenneth W , Goberdhan Deborah CI , O'Driscoll Lorraine , Théry Clotilde , Welsh Joshua A , Blenkiron Cherie , Buzás Edit I , Di Vizio Dolores , Erdbrügger Uta , Falcón‐Pérez Juan M , Fu Qing‐Ling , Hill Andrew F , Lenassi Metka , Lötvall Jan , Nieuwland Rienk , Ochiya Takahiro , Rome Sophie , Sahoo Susmita , Zheng Lei 
Published: December 2021

AbstractThe minimal information for studies of extracellular vesicles (EVs, MISEV) is a field‐consensus rigour initiative of the International Society for Extracellular Vesicles (ISEV). The last update to MISEV, MISEV2018, was informed by input from more than 400 scientists and made recommendations in the six broad topics of EV nomenclature, sample collection and pre‐processing, EV separation and concentration, characterization, functional studies, and reporting requirements/exceptions. To gather opinions on MISEV and ideas for new updates, the ISEV Board of Directors canvassed previous MISEV authors and society members. Here, we share conclusions that are relevant to the ongoing evolution of the MISEV initiative and other ISEV rigour and standardization efforts.
Ultrashort Echo Time Magnetic Resonance Imaging Techniques: Met and Unmet Needs in Musculoskeletal Imaging
Authors: Afsahi Amir Masoud , Ma Yajun , Jang Hyungseok , Jerban Saeed , Chung Christine B. , Chang Eric Y. , Du Jiang 
Published: December 2021

This review article summarizes recent technical developments in ultrashort echo time (UTE) magnetic resonance imaging of musculoskeletal (MSK) tissues with short‐T2 relaxation times. A series of contrast mechanisms are discussed for high‐contrast morphological imaging of short‐T2 MSK tissues including the osteochondral junction, menisci, ligaments, tendons, and bone. Quantitative UTE mapping of T1, T2*, T1ρ, adiabatic T1ρ, magnetization transfer ratio, MT modeling of macromolecular proton fraction, quantitative susceptibility mapping, and water content is also introduced. Met and unmet needs in MSK imaging are discussed.Evidence Level1Technical EfficacyStage 3
MRA of the Supraaortic Vasculature: Comparison of Gadobutrol and Gadoterate Meglumine at 1.5 T
Authors: Cerne John W. , Pathrose Ashitha , Singer Alyssa M. , Moore Jackson E. , Serhal Ali , Aouad Pascale , Umair Muhammad , Ragin Ann , Allen Bradley D. , Avery Ryan , Markl Michael , Carr James C. 
Published: December 2021

BackgroundGadobutrol (GB) and gadoterate meglumine (GM) are contrast agents used for contrast‐enhanced magnetic resonance angiography (CEMRA). Supraaortic vasculature (SAV) CEMRAs are used to evaluate stroke risk and neurologic symptoms. There is a need to compare the SAV CEMRA image quality obtained with GB and GM.PurposeTo intra‐individually compare MRA images obtained with equimolar GB and GM at 1.5 T in the SAV.Study TypeProspective, crossover.PopulationTwenty‐eight subjects (54 ± 13 years; 17 female).Field Strength/Sequence1.5 T; three‐dimensional (3D) gradient recalled echo.AssessmentQuantitative image quality was measured by normalized signal intensity (SIn) [SIn = SI blood/SD blood] and contrast ratio (CR) [CR = SI blood/SI muscle], determined by an observer (JWC) with 1 year of vascular imaging experience. Three radiologists (AS, PA, and MU) with (5, 5, and 6 years of) vascular imaging experience evaluated image quality by Likert‐scale ratings (of image impression, wall conspicuity, and artifact absence).Statistical TestsSIn and CR were compared with paired t‐tests or Wilcoxon signed‐rank tests and Bland–Altman plots. Qualitative ratings were compared with Wilcoxon signed‐rank test.ResultsNo significant difference in SIn was found between GB and GM. CRs with GB were significantly higher than GM at the right common carotid (6.9 ± 2.5 vs. 4.8 ± 1), left internal carotid (7.3 ± 2 vs. 4.4 ± 1.2), right internal carotid (7.7 ± 2.2 vs. 5 ± 1.1), and left vertebral (6.6 ± 2.2 vs. 4.5 ± 1.1) arteries. Bland–Altman plots showed relatively greater differences between GB and GM at higher CRs and SIns. GM showed significantly higher artifact than GB (3.56 ± 0.52 vs. 3.36 ± 0.46) and significantly lower overall image quality (10.73 ± 1.45 vs. 11.26 ± 1.58) at the left vertebral artery.Data ConclusionAt 1.5 T and equimolar demonstration, GB (0.1 mL/kg, i.e., 0.1 mmol/kg) showed higher CRs in the SAV compared to GM (0.2 mL/kg, i.e., 0.1 mmol/kg) at most vessels. Subjective image quality was not significantly different between the two agents for most vessels.Level of Evidence2Technical EfficacyStage 2
Maintenance shelf‐life quality of cocktail tomatoes by using UV‐C illumination and Arabic gum coating
Authors: Kurubas Mehmet S , Yildirim Isilay K , Ali Qasid , Erkan Mustafa 
Published: December 2021

AbstractBACKGROUNDThe aim of the study was to investigate the effects of Arabic gum (AG) coating, UV‐C illumination and its combinations on postharvest quality parameters of cocktail tomatoes (Solanum lycopersicum L. cv. Ipekce F1). After harvest, mature green tomatoes were treated with 10% Arabic gum (AG10), 20% AG (AG20), 3.6 kJ m−2 ultraviolet‐C (UV‐C) illumination, 3.6 kJ m−2 UV‐C+AG10 and 3.6 kJ m−2 UV‐C+AG20, and stored at 20 °C for 20 days.RESULTSThe highest titratable acidity (TA), total soluble solids (TSS) and the lowest weight loss were obtained in AG20 treatments. Maximum fruit firmness and L* value were in AG20 and UV‐C+AG20 treatment. The greatest h° values were recorded in AG20, UV‐C+AG20 and control group. The highest vitamin C content were obtained from AG20, UV‐C+AG10 and UV‐C+AG20 treated tomatoes. Minimum lycopene content was determined from AG10, AG20, UV‐C+AG10 and UV‐C+AG20 treatments. Maximum chlorophyll content was determined from UV‐C+AG20‐treated tomatoes. AG10, AG20, UV‐C+AG10 and UV‐C+AG20 treatments resulted in lower ethylene emissions as compared to control and UV‐C‐treated tomatoes. AG20, UV‐C+AG10 and UV‐C+AG20 treatments generally had lower values than control and UV‐C in term of respiration rates.CONCLUSIONIt is concluded that AG20 treatment effectively maintained the postharvest quality and biochemical properties of cocktail tomatoes as compared to other tested treatments. © 2021 Society of Chemical Industry.
A Technique to Reduce the Early Recurrence of Intussusception in Ultrasound‐Guided Hydrostatic Reduction
Authors: Yu Feng , Chen Huanhua , Cao Xiaoqing , Mao Weihao , Jiang Shuanglan , Yao Zhiguang , Zhang Min 
Published: December 2021

ObjectivesUltrasound‐guided saline enema is highly successful in treating pediatric intussusception; however, early recurrence—within 48 hours—is possible. This study aimed to explore effective methods of reducing early recurrence.MethodsThis study included patients aged 0 to 14 years diagnosed with ileocolic intussusception with a symptom duration of <48 hours from January 2019 to March 2021. The patients were divided into control and intervention groups. All patients received successful treatment with ultrasound‐guided saline enema; however, in patients treated before January 4, 2020 (control group), the intestinal fluid was drained immediately, and in patients treated after January 4, 2020 (intervention group), the intestinal fluid was drained after 15 minutes of intestinal pressure maintenance. Early recurrence rates of the groups were compared.ResultsIleocolic intussusception was treated successfully by ultrasound‐guided saline enema in 231 patients (116, control group;115, intervention group). The early recurrence rate in the intervention group (10%; 95% CI: 4.9–16.5) was numerically lower than that in the control group (19%; 95% CI: 12.3–27.3). No significant difference was observed in the number of recurrences per person between the groups (P = .448). Patients without early recurrence were older (P = .004) and received enemas of a shorter duration (P < .001) and lower pressure (P < .001) than patients without early recurrence.ConclusionsMaintaining reduction pressure for 15 minutes after a successful ultrasound‐guided saline enema may reduce the early recurrence of intussusception. A randomized controlled trial is needed because the intervention and control cohorts were most probably incomparable (due to the COVID‐19 pandemic).
Steam reforming of ethanol to hydrogen formation: Kinetic modeling and experimental investigations
Authors: Mosayebi Amir 
Published: December 2021

AbstractTo derive the kinetic model for steam reforming of ethanol, the experiment tests were accomplished at vast working conditions (i.e., temperature: 300–900°C, pressure: 1–11 bar, and H2O/C2H5OH ratio (S/E) of 3–21) on the Ni‐Pt/CeO2 catalyst in a fixed bed reactor. The physicochemical properties of the prepared catalyst were investigated by x‐ray fluorescence, thermal gravimetric analysis x‐ray diffractometer, and N2 adsorption/desorption Brunauer‐Emmett‐Teller (BET) tests. The kinetic model was developed based on the Langmuir–Freundlich approach, and the proposed mechanism included four reversible reactions on two types of the active site. The values of estimated activation energy for four reactions were in the range of reported values by various workers. The kinetic model error to anticipate the responses was 11.96% and a well forecasted H2 yield compared to other responses. The complete ethanol conversion reached above 700°C at 1 bar pressure irrespective of the S/E value. The variation of CO yield in terms of temperature was very low up to 700°C. An augmentation in S/E, enhanced ethanol conversion and H2 yield, while these trends were reversed for CO yield and CH4 selectivity.
The Prognostic Value of Human Papilloma Virus Infection in Oral Cavity Squamous Cell Carcinoma: A Meta‐Analysis
Authors: Christianto Stephanus , Li Kar Yan , Huang Ting Hsiang , Su Yu‐Xiong 
Published: December 2021

Objectives/HypothesisHuman papilloma virus (HPV) infection has been confirmed as a favorable prognostic factor in oropharyngeal cancer. However, the prognostic value of HPV in oral squamous cell carcinoma (OSCC) is still unclear. Therefore, a systematic review and meta‐analysis was performed to evaluate the prognostic value of HPV infection in OSCC patients.Study DesignSystematic literature review with meta‐analysis.MethodsA systematic literature review was conducted in accordance with PRISMA guidelines in PubMed, EMBASE, and MEDLINE databases. The primary outcomes were overall survival (OS), disease‐free survival (DFS), disease‐specific survival (DSS), and secondary outcomes were local control (LC), regional control (RC), and distant control (DC).ResultsA total of 22 articles with 3065 OSCC patients were included in this study. Meta‐analysis demonstrated that compared to HPV‐negative OSCC patients, HPV‐positive OSCC patients had a significantly shorter OS (hazard ratio [HR] = 1.45, 95% confidence intervals [CI], 1.10–1.93) and lower DC (HR = 2.16, 95% CI, 1.54–3.04). There was no significant difference in DFS (HR = 1.20, 95% CI, 0.63–2.26), DSS (HR = 1.20, 95% CI, 0.63–2.26), LC (HR = 1.44, 95% CI, 0.97–2.14), and RC (HR = 1.50, 95% CI, 0.98–2.30) between HPV‐positive and negative OSCC patients. Sensitivity analysis confirmed the above results.ConclusionsOur systematic review and meta‐analysis reveal that HPV‐positive is associated with significantly decreased OS and DC, suggesting HPV infection is an adverse prognostic factor in OSCC. Laryngoscope, 132:1760–1770, 2022
Implementing a Tailored Psychosocial Distress Screening Protocol in a Head and Neck Cancer Program
Authors: Brauer Eden R. , Lazaro Stephanie , Williams Charlene L. , Rapkin David A. , Madnick Amy B. , Dafter Roger , Cheng Guo , Porter Ashleigh , Abemayor Elliot , Chai‐Ho Wanxing , Morasso Elizabeth , Erman Andrew , Chhetri Dinesh , St. John Maie , Wong Deborah J. 
Published: December 2021

Objectives/HypothesisPsychosocial distress is common among patients with head and neck cancer (HNC) and is associated with poorer quality of life and clinical outcomes. Despite these risks, distress screening is not widely implemented in HNC care. In this study, we investigated the prevalence of psychosocial distress and its related factors in routine care of patients with HNC.MethodsData from medical records between September 2017 and March 2020 were analyzed. Psychosocial distress was measured by the National Comprehensive Cancer Network's Distress Thermometer (DT), and a modified HNC‐specific problem list; depression and anxiety were assessed using the Patient Health Questionnaire‐4. Descriptive statistics and logistic regression were conducted to report prevalence of distress, depression and anxiety, and factors associated with clinical distress. Implementation outcomes, including rates of referrals and follow‐up for distressed patients, are also reported.ResultsTwo hundred and eighty seven HNC patients completed the questionnaire (age 64.3 ± 14.9 years), with a mean distress score of 4.51 ± 3.35. Of those, 57% (n = 163) reported clinical distress (DT ≥ 4). Pain (odds ratio [OR] = 3.31, 95% CI = 1.75–6.26), fatigue (OR = 2.43, 95% CI = 1.1.7–5.05), anxiety (OR = 1.63, 95% CI = 1.30–2.05), and depression (OR = 1.51, 95% CI = 1.04–2.18) were significantly associated with clinical distress (P < .05). Of patients identified as distressed, 79% received same‐day psychosocial evaluation.ConclusionsClinical distress was identified in 57% of patients who completed the questionnaire, suggesting that an ultra‐brief psychosocial screening protocol can be implemented in routine ambulatory oncology care, and identifies patients whose distress might otherwise go unrecognized.Level of Evidence4 Laryngoscope, 132:1600–1608, 2022
Rational Design of Polyphosphorylcholine‐Based Micelles for Superior Anti‐Biofilm Activity
Authors: Zhou Liangqin , Lei Dongqin , Wang Quan , Ouyang Yaowen , Luo Xianglin 
Published: December 2021

AbstractIt's a great challenge to completely eradicate the bacteria in biofilms by antimicrobials, since the cells are wrapped in the dense extracellular polymeric substances. Herein, in order to deliver antibacterial agents into staphylococcal biofilms and to kill the bacteria in the biofilms, an amphiphilic polymer with tertiary amine groups, poly(2‐methacryloyloyethyl phosphorylcholine)‐b‐poly {α‐[4‐(diethylamino)methyl‐1,2,3‐triazol]‐caprolactone‐co‐caprolactone} (PMPC‐PDCL) is synthesized, and its micelles are used as carriers for a model antimicrobial triclosan (TCS) to research the effect of polymeric components on antibiofilm. Polycaprolactone‐b‐poly(2‐methacryloyloxyethyl phosphorylcholine) (PMPC‐PCL) and poly(ethylene glycol)‐b‐polycaprolactone (PEG‐PCL) are designed as contrast materials. The results demonstrate that PMPC‐PDCL micelles possess the highest drug loading, and the accumulative TCS release rate of PMPC‐PDCL/TCS micelles at pH 5.5+lipase is highest. The minimum bactericidal concentration value of PMPC‐PDCL/TCS micelles is 64 µg mL−1. According to the confocal laser scanning microscopy, the penetration effect of PMPC‐PDCL micelles is the best, followed by PMPC‐PCL and PEG‐PCL micelles. PMPC‐PDCL/TCS micelles display excellent anti‐biofilm both on account of their outstanding penetration effect and drug release behavior in acidic and lipase environments. Thus, PMPC‐PDCL micelles can be used as carriers to deliver the antibacterial agents into biofilms, which has important significance to cure diseases caused by bacterial infection.
The persuasiveness of metaphor in advertising
Authors: Septianto Felix , Pontes Nicolas , Tjiptono Fandy 
Published: December 2021

AbstractMetaphor—drawing a comparison between two seemingly incompatible concepts in an effort to create symbolism—is frequently used in advertising. This study investigates the persuasiveness of metaphor in advertising and the conditions under which the effectiveness of metaphorical advertisements can be leveraged. Across three experimental studies, the results show that mixed emotional appeals (happiness and sadness) versus positive emotional appeals (happiness) can increase the persuasiveness of an advertising metaphor. Furthermore, cognitive flexibility mediates this effect. This study contributes to the literature on metaphor in advertising by showing the benefits of using mixed emotional appeals and establishing the underlying process. Moreover, the findings can be beneficial for marketers in designing effective marketing communication strategies combining mixed emotions with a metaphor.
The influence of humor in advertising: Explaining the effects of humor in two‐sided messsages
Authors: Eisend Martin 
Published: December 2021

AbstractResearch on advertising containing negative information, such as two‐sided messages, has neglected the potential of including humor in the advertisements, although both theory and practical examples suggest that humor might help to sell negative information. This paper presents the results from three studies that showed that humor can increase the persuasive influence of two‐sided advertising due to a positive surprise effect. However, it can also reduce this effect for high‐involvement consumers due to a negative distraction effect. Because two‐sided advertising is particularly effective in targeting high‐involvement consumers, this study established humor–product fit as a boundary condition to help mitigate the negative effects on high‐involvement consumers who are exposed to two‐sided advertising messages. When the fit between product and humor is high, the persuasiveness of two‐sided advertising for high‐involvement consumers increases. The study's findings have implications for theory and for the practice of including negative information in advertising. Humor can be applied in two‐sided advertising if consumers are highly involved and the humor is appropriate to the product.