bluuebunny/crossref_metadata_2025_split huggingface dataset:
Population Dynamics of Hybrid State during Adaptive Therapy in Cancer
Authors: Singh Ghanendra 
Published: November 2021

AbstractDrug resistance emerges due to drug-induced phenotypic switching of drug-sensitive to drug-resistant subpopulations in cancer during therapy. Existing models indicate the competitive advantage of sensitive over resistant population to regulate tumor and reducing the treatment cost with increased time to progression of tumor ultimately benefiting the patient in a clinical setting. Here, we present a Lotka Volterra (LV) based population dynamics (PD) model of the drug-sensitive, drug-resistant, and transient drug-hybrid state along with phenotypic switching during adaptive therapy based on a simple cancer biomarker (CB) to decide the adaptive therapy dosage to regulate cancer. We identified that the strength of intra competition along with phenotypic switching parameters is crucial to mediate the effectiveness of adaptive therapy and also investigated the significance of the initial fraction of subpopulations on AT. We hypothesize and predict the dynamics of drug-induced transient hybrid state playing a key role in the cancer cells undergoing metastasis.
Computational and biochemical analyses reveal that cofilin-2 self assembles into amyloid-like structures and promotes the aggregation of other proteinaceous species: Pathogenic relevance to myopathies
Authors: Kaushik Vibha , Hanschmann Eva-Maria , Brünnert Daniela , Prerna Kumari , Anand Bibin G. , Sharma Phulwanti Kumari , Kar Karunakar , Goyal Pankaj 
Published: November 2021

AbstractCofilin-2 is a member of the ADF/cofilin family, expressed extensively in adult muscle cells and involved in muscle maintenance and regeneration. Phosphorylated cofilin-2 is found in pre-fibrillar aggregates formed during idiopathic dilated cardiomyopathy. A recent study shows that phosphorylated cofilin-2, under oxidative distress, forms fibrillar aggregates. However, it remains unknown if cofilin-2 holds an innate propensity to form amyloid-like structures. In the present study, we employed various computational and biochemical techniques to explore the amyloid-forming potential of cofilin-2. We report that cofilin-2 possesses aggregation-prone regions (APRs), and these APRs get exposed to the surface, become solvent-accessible, and are involved in the intermolecular interactions during dimerization, an early stage of aggregation. Furthermore, the cofilin-2 amyloids, formed under physiological conditions, are capable of cross-seeding other monomeric globular proteins and amino acids, thus promoting their aggregation. We further show that Cys-39 and Cys-80 are critical in maintaining the thermodynamic stability of cofilin-2. The destabilizing effect of oxidation at Cys-39 but not that at Cys-80 is mitigated by Ser-3 phosphorylation. Cysteine oxidation leads to partial unfolding and loss of structure, suggesting that cysteine oxidation further induces early events of cofilin-2 aggregation. Overall, our results pose a possibility that cofilin-2 amyloidogenesis might be involved in the pathophysiology of diseases, such as myopathies. We propose that the exposure of APRs to the surface could provide mechanistic insight into the higher-order aggregation and amyloidogenesis of cofilin-2. Moreover, the cross-seeding activity of cofilin-2 amyloids hints towards its involvement in the hetero-aggregation in various amyloid-linked diseases.
Antipsychotic Polypharmacy and Adverse Drug Reactions Among Adults in a London Mental Health Service, 2008-2018
Authors: Yang Justin C. , Thygesen Johan H. , Werbeloff Nomi , Hayes Joseph F. , Osborn David P.J. 
Published: November 2021

AbstractBackgroundAntipsychotic polypharmacy (APP) occurs commonly but it is unclear whether it is associated with an increased risk of adverse drug reactions. Electronic health records (EHRs) offer an opportunity to examine APP using real-world data. In this study, we use EHR data to identify periods when patients were prescribed 2+ antipsychotics and compare these with periods of antipsychotic monotherapy. To determine the relationship between APP and subsequent instances of adverse drug reactions: QT interval prolongation, hyperprolactinaemia, and increased body weight (body mass index [BMI] ≥ 25).MethodsWe extracted anonymised EHR data. Patients aged 16+ receiving antipsychotic medication at Camden & Islington NHS Foundation Trust between 1 January 2008 and 31 December 2018 were included. Multilevel mixed-effects logistic regression models were used to elucidate the relationship between APP and the subsequent presence of QT interval prolongation, hyperprolactinaemia, and/or increased BMI following a period of APP within 7, 30, or 180 days respectively.ResultsWe identified 35,409 observations of antipsychotic prescribing among 13,391 patients. APP was associated with a subsequent increased risk of hyperprolactinaemia (adjusted odds ratio 2.46; 95% C.I. 1.87-3.24) and of having a BMI > 25 (adjusted odds ratio 1.75; 95% C.I. 1.33-2.31) in the period following the APP prescribing.ConclusionsOur observations suggest that APP should be carefully managed with attention to hyperprolactinaemia and obesity.
A systematic scoping review on the impact of the COVID-19 quarantine on the psychological wellbeing of medical students
Authors: Vythilingam Divya I. , Atiomo William U. 
Published: November 2021

AbstractObjectivesThe goal of this study was to identify the nature and extent of the available published research on the impact of social isolation, on the psychological wellbeing of medical students, who had to quarantine due to the COVID-19 pandemic.DesignScoping review.Search strategyThe PRISMA-ScR (Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews), guideline, was used to structure this study. A search strategy was carried out across six bibliographic databases. PubMed, Embase, ERIC, Scopus, Cochrane Database of Systematic Reviews and Web of Science. The following search terms were used, “medical student*” AND “impact” AND “quarantine” AND “COVID-19”. Searches were confined to articles published (excluding conference abstracts) between 1 January 2019-21 August 2021. A search of secondary references was conducted. Data from the selected studies were extracted, and the following variables recorded; first author and year of publication, country of study, study design, sample size, focus group, mode of analyzing impact of quarantine from COVID-19 on mental health and results of the studies.ResultsA total of 223 articles were identified across the six databases, from which 69 duplicates were excluded resulting in 154 full-text articles. Of these, 29 met the inclusion criteria. Following a review of the abstracts of these 29, ten full-text articles were identified all of which were cross sectional studies. Sample sizes ranged from 182 to 860 students and all studies used a variety of self-administered questionnaires to measure psychological wellbeing. Eight of the 10 articles showed that quarantine had a negative impact on the psychological well-being of medical students.ConclusionThe evidence is small but growing. Quarantine because of the COVID-19 pandemic appears to have had a negative impact on the psychological wellbeing of medical students. There is a need for more studies to further evaluate this research question.Article summaryStrengths and limitations of this study.This was the first scoping review as far as we know of the literature in this area.Many of the studies analysed in this review were cross-sectional in nature.A variety of measurement tools were used to assess psychological wellbeing, preventing comparison of results and data synthesis.Many of the studies included in the review did not include a control group of medical students, pre-COVID-19 quarantine.A detailed critical appraisal of the studies included was not conducted, however this is not mandatory for scoping reviews.
Graph Ricci Curvatures Reveal Atypical Functional Connectivity in Autism Spectrum Disorder
Authors: Elumalai Pavithra , Yadav Yasharth , Williams Nitin , Saucan Emil , Jost Jürgen , Samal Areejit 
Published: November 2021

SUMMARYWhile standard graph-theoretic measures have been widely used to characterize atypical resting-state functional connectivity in autism spectrum disorder (ASD), geometry-inspired network measures have not been applied. In this study, we apply Forman-Ricci and Ollivier-Ricci curvatures to compare networks of ASD and typically developing individuals (N = 1112) from the Autism Brain Imaging Data Exchange I (ABIDE-I) dataset. We find brain-wide and region-specific ASD-related differences for both Forman-Ricci and Ollivier-Ricci curvatures, with region-specific differences concentrated in Default Mode, Somatomotor and Ventral Attention networks for Forman-Ricci curvature. We use meta-analysis decoding to demonstrate that brain regions with curvature differences are associated to those cognitive domains known to be impaired in ASD. Further, we show that brain regions with curvature differences overlap with those brain regions whose non-invasive stimulation improves ASD-related symptoms. These results suggest the utility of graph Ricci curvatures in characterizing atypical connectivity of clinically relevant regions in ASD and other neurodevelopmental disorders.
Social network analysis of Twitter data from Pakistan during COVID-19
Authors: Batool Syeda Hina , Ahmed Wasim , Mahmood Khalid , Sharif Ashraf 
Published: November 2021

Purpose
The use of social media has increased during the COVID-19 pandemic. Social media platforms provide opportunities to share news, ideas and personal stories. Twitter is used by citizens in Pakistan to respond and comment on emerging news stories and events. However, it is not known whether Twitter played a positive or negative role in spreading updates and preventive messages during the COVID-19 pandemic. The purpose of this study is to analyse content from Twitter during the pandemic.

Design/methodology/approach
NodeXL was used to retrieve data using the keyword وائرس کورونا (written in Urdu and which translates to Coronavirus). The first data set (Case Study 1) was based on 10,284 Twitter users from the end of March. The second data set (Case Study 2) was based on 10,644 Twitter users from the start of April. The theoretical lens of effective message framing was used to classify the most retweeted content on Twitter.

Findings
Twitter was used for personal and professional projections and included certain tweets included political motives even during the unfolding health crisis. There appeared to be very few successful attempts to use Twitter as a tool for health awareness and risk communication. The empirical findings indicate that the most retweeted messages were gain-framed and can be classified as personal, informative and political in nature.

Originality/value
The present study provides insights likely to be of interest to researchers, health organizations, citizens, government and politicians that are interested in making more effective use of social media for the purposes of health promotion. The authors also provide novel insights into the key topics of discussions, websites and hashtags used by Pakistani Twitter users during the COVID-19 pandemic.
Labor market policies, informality and misallocation
Authors: Jha Priyaranjan , Hasan Rana 
Published: November 2021

Purpose
The purpose of this paper is to understand labor market regulations and their consequences for the allocation of resources.

Design/methodology/approach
This paper constructs a theoretical model to study labor market regulations in developing countries and how it affects the allocation of resources between the less productive informal activities and more productive formal activities. It also provides empirical support for some theoretical results using cross-country data.

Findings
When workers are risk-averse and the market for insurance against labor income risk is missing, regulations that provide insurance to workers (such as severance payments) reduce misallocation. However, regulations that simply create barriers to the dismissal of workers increase misallocation and end up reducing the welfare of workers. This study also provides some empirical evidence broadly consistent with the theoretical results using cross-country data. While dismissal regulations increase the share of informal employment, severance payments to workers do not.

Research limitations/implications
The empirical exercise is constrained by the lack of availability of good data on the informal sector.

Originality/value
The analysis of the alternative labor market regulations analyzed in this paper in the presence of risk-averse workers is an original contribution to the literature.
The influence of 3-DOF film thickness disturbance on transient performance of typical spiral groove dry gas seals
Authors: Chen Yuan , Shang Hao , Li Xiaolu , Li Yuntang , Wang Bingqing , Peng Xudong 
Published: November 2021

Purpose
The purpose of this paper is to investigate the influence rule and mechanism of three degrees of freedom film thickness disturbance on the transient performance of spiral groove, upstream pumping spiral groove dry gas seal (UP-SDGS) and double-row spiral groove dry gas seal (DR-SDGS).

Design/methodology/approach
The transient performance of spiral groove, UP-SDGS and DR-SDGS are obtained by solving the transient Reynolds equation under different axial and angular disturbance coefficients. The transient and steady performance of the above-mentioned DGSs are compared and analyzed.

Findings
The film thickness disturbance has a remarkable impact on the sealing performance of DGS with different structures and the calculation deviations of the leakage rate of the UP-DGS will increase significantly if the film thickness disturbance is ignored. The axial and angular disturbance jointly affect the film thickness distribution of DGS, but there is no significant interaction between them on the transient sealing performance.

Originality/value
The influence mechanism of axial disturbance and angular disturbance on the transient performance of typical SDGSs behavior has been explained by theory. Considering small and large disturbance, the interaction between axial disturbance and angular disturbance on the transient performance have been studied.
Developing a measure to assess clinicians’ ability to reflect on key staff–patient dynamics in forensic settings
Authors: Polnay Adam , Walker Helen , Gallacher Christopher 
Published: November 2021

PurposeRelational dynamics between patients and staff in forensic settings can be complicated and demanding for both sides. Reflective practice groups (RPGs) bring clinicians together to reflect on these dynamics. To date, evaluation of RPGs has lacked quantitative focus and a suitable quantitative tool. Therefore, a self-report tool was designed. This paper aims to pilot The Relational Aspects of CarE (TRACE) scale with clinicians in a high-secure hospital and investigate its psychometric properties.Design/methodology/approachA multi-professional sample of 80 clinicians were recruited, completing TRACE and attitudes to personality disorder questionnaire (APDQ). Exploratory factor analysis (EFA) determined factor structure and internal consistency of TRACE. A subset was selected to measure test–retest reliability. TRACE was cross-validated against the APDQ.FindingsEFA found five factors underlying the 20 TRACE items: “awareness of common responses,” “discussing and normalising feelings;” “utilising feelings,” “wish to care” and “awareness of complicated affects.” This factor structure is complex, but items clustered logically to key areas originally used to generate items. Internal consistency (α= 0.66, 95% confidence interval (CI) = 0.55–0.76) demonstrated borderline acceptability. TRACE demonstrated good test–retest reliability (intra-class correlation = 0.94, 95% CI = 0.78–0.98) and face validity. TRACE indicated a slight negative correlation with APDQ. A larger data set is needed to substantiate these preliminary findings.Practical implicationsEarly indications suggested TRACE was valid and reliable, suitable to measure the effectiveness of reflective practice.Originality/valueThe TRACE was a distinctive measure that filled a methodological gap in the literature.
Hibiscus sabdariffa L. calyces’ and argon DBD plasma: potential eco-friendly cleaners for fire-damaged silver gelatin prints
Authors: Elattar Laila M. , Darwish Sawsan S. , Rashed Usama M. , Ali Maha Ahmed , Eldeighdye Shaimaa M. 
Published: November 2021

Purpose
This paper aims at examining the potentiality of using Hibiscus sabdariffa L. calyces’ (Hs) aqueous extract to remove soot stains from the surface of fire-damaged silver gelatin prints. It further studies the cleaning efficiency and impact of both a contact method and a noncontact method with argon dielectric barrier discharge plasma (DBD Ar. plasma) on the different properties of silver gelatin prints. Accordingly, it prompts using economic, eco-friendly materials and methods in the photograph conservation field.

Design/methodology/approach
To achieve the aims of this paper, four silver gelatin prints were stained with soot and treated with the Hs aqueous extract as a contact method and DBD Ar. plasma combined with the aqueous extract as a noncontact method. The assessment was carried out using digital microscopy, atomic force microscopy and spectrophotometer to study the efficiency of the tested treatments and their impact on the surface of the photographs. Fourier transform infrared was used to monitor the state of the binder after cleaning. Furthermore, the pH and the mechanical properties were measured.

Findings
The contact method resulted in lower concentrations of Hs extract that efficiently cleaned the surface without causing any stains or damage to the treated photographs. The noncontact method (plasma with an aqueous extract) proved to be less effective in cleaning and made the binder more susceptible to deterioration.

Originality/value
This paper reveals the success of Hs aqueous extract in cleaning soot on vulnerable photographs' surfaces.
Effects of green technology plasma pre-treatment on the wettability and ink adhesion of paper
Authors: Özsoy Samed Ayhan , Acıkel Safiye Meriç , Aydemir Cem 
Published: November 2021

Purpose
The surface energy of the printing material can be increased to desired levels with different chemicals or methods. However, the important thing is that the surface properties of printing material are not affected negatively. In this way the aim of this paper provide that the surface properties of matte and glossy coated paper is improved by the argon containing atmospheric pressure plasma device because the plasma treatment method does not occur surface damaging on the papers.

Design/methodology/approach
In experimental studies, test samples cut from 160 mm × 30 mm in size from 115 g/m2 gloss- and matt-coated papers were used. The plasma treatments of paper samples were carried out with an argon containing atmospheric pressure plasma device of laboratory scale that produces plasma of the corona discharge type at radio frequency. The optimized plasma parameters were at a frequency of 20 kHz and plasma power 200 W. A copper electrode of length 12 cm and diameter 2.5 mm was placed in the centre of the nozzle.

Findings
Research findings showed that the surface energies of the papers increased with the increase in plasma application time. While the contact angle of the untreated glossy paper is 82.2, 8 second plasma applied G3 sample showed 54 contact angle value. Similarly, the contact angle of the base paper of matt coated is 91.1, while M3 is reduced to 60.4 contact angles by the increasing plasma time.

Originality/value
Plasma treatment has shown that no chemical coating is needed to increase the wettability of the paper surface by reducing the contact angle between the paper and the water droplet. In addition, the surface energies of all papers treated by argon gas containing atmospheric pressure plasma, increased. Plasma treatment provides to improve both the wettability of the paper and the adhesion property required for the ink, with an environmentally friendly approach.
A fabrication and characterization of luffa/PANI/PEO biocomposite nanofibers by means of electrospinning
Authors: Konuk Ege Gözde , Yüce Hüseyin , Akay Özge , Öner Hasbi , Genç Garip 
Published: November 2021

Purpose
This paper aims to address the production of biocomposite nanofibers using luffa natural fibers and polyaniline conductive polymer/polyethylene oxides (PANI/PEO).

Design/methodology/approach
In this study, luffa natural fibers are extracted by chemical method. After mixing the treated luffa (TL) with the PANI/PEO solution, TL/PANI/PEO nanofibers were produced by electrospinning (ES) method under different ES parameters to examine the optimal conditions for nanofiber production. Then TL/PANI/PEO biocomposite nanofibers prepared in different weight ratios were produced to analyze the effects of luffa in the morphology and thermal properties of the biocomposite nanofibers. The characterization analysis of TL/PANI/PEO biocomposite nanofibers was performed by scanning electron microscopy, Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) analysis methods.

Findings
The analysis shows that different weight ratios of TL to PANI/PEO changed the morphology of the membrane. When increasing the weight ratio of TL, the morphological structure of TL/PANI/PEO transformed from nanofiber structure to thin film structure. The appearance of O—H peaks in the FTIR results proved the existence of TL in PANI/PEO nanofibers (membrane). Moreover, an increase in the weight ratio of luffa from 2% to 7.5% leads to an increase in the peak intensity of the O—H group. Regarding DSC analysis, biocomposite nanofibers improved the thermal properties. According to all results, 2%wt TL/PANI/PEO showed optimal morphological properties.

Originality/value
Plant cellulose was extracted from the luffa, one of the natural fibers, by method of alkali treatment. A new type of biocomposite nanofibers was produced using TL blend with PANI via electrospinning method.
“They said we ruined the character and our religion”: authenticity and legitimation ofhijabcosplay
Authors: El Jurdi Hounaida , Moufahim Mona , Dekel Ofer 
Published: November 2021

PurposeThis research is positioned at the intersection of youth subculture consumption and religious affiliation, through the study of observant Muslim women involved in the highly engaging and codified activity of cosplay. Given authenticity is central to the cosplay visual impact and performance, this study aims to understand the wayhijabcosplayers negotiate tensions between authentic body performativity and the observance of religious dressing codes.Design/methodology/approachA qualitative interpretive approach was used to address the research questions. In-depth semi-structured online interviews were conducted with 25 members of ahijabcosplayers from South East Asia.FindingsThe concept of authenticity emerged as multifaceted forhijabcosplayers, where they manage three different aspect of the authentic cosplay performance as follows: authenticity as a cosplayer (social dimension of authenticity), authenticity to the character (personal dimension of authenticity) and authenticity to their religious identity (religious dimension of authenticity). The subsequent malleable authenticity is used to legitimate cosplay as an acceptable performative practice from a religious and from subcultural view.Originality/valueThe research highlights how tensions between identity and performativity of the body are negotiated. More specifically, the study contributes to the understanding of the wayhijabcosplayers reconcile tensions between religious identity and the performativity of the body. Given the role of the body as a site for negotiating identity, this study provides important insights in the tensions and strategies at the intersection of authenticity, embodiment and religious identity in youth cultures.