bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ipatasertib plus paclitaxel for PIK3CA/AKT1/PTEN-altered hormone receptor-positive HER2-negative advanced breast cancer: primary results from cohort B of the IPATunity130 randomized phase 3 trial
Authors: Turner Nicholas , Dent Rebecca A. , O’Shaughnessy Joyce , Kim Sung-Bae , Isakoff Steven J. , Barrios Carlos , Saji Shigehira , Bondarenko Igor , Nowecki Zbigniew , Lian Qinshu , Reilly Sarah-Jayne , Hinton Heather , Wongchenko Matthew J. , Kovic Bruno , Mani Aruna , Oliveira Mafalda 
Published: December 2021

Abstract
Purpose
PI3K/AKT pathway alterations are frequent in hormone receptor-positive (HR+) breast cancers. IPATunity130 Cohort B investigated ipatasertib–paclitaxel in PI3K pathway-mutant HR+ unresectable locally advanced/metastatic breast cancer (aBC).

Methods
Cohort B of the randomized, double-blind, placebo-controlled, phase 3 IPATunity130 trial enrolled patients with HR+ HER2-negative PIK3CA/AKT1/PTEN-altered measurable aBC who were considered inappropriate for endocrine-based therapy (demonstrated insensitivity to endocrine therapy or visceral crisis) and were candidates for taxane monotherapy. Patients with prior chemotherapy for aBC or relapse < 1 year since (neo)adjuvant chemotherapy were ineligible. Patients were randomized 2:1 to ipatasertib (400 mg, days 1–21) or placebo, plus paclitaxel (80 mg/m2, days 1, 8, 15), every 28 days until disease progression or unacceptable toxicity. The primary endpoint was investigator-assessed progression-free survival (PFS).

Results
Overall, 146 patients were randomized to ipatasertib–paclitaxel and 76 to placebo–paclitaxel. In both arms, median investigator-assessed PFS was 9.3 months (hazard ratio, 1.00, 95% CI 0.71–1.40) and the objective response rate was 47%. Median paclitaxel duration was 6.9 versus 8.8 months in the ipatasertib–paclitaxel versus placebo–paclitaxel arms, respectively; median ipatasertib/placebo duration was 8.0 versus 9.1 months, respectively. The most common grade ≥ 3 adverse events were diarrhea (12% with ipatasertib–paclitaxel vs 1% with placebo–paclitaxel), neutrophil count decreased (9% vs 7%), neutropenia (8% vs 9%), peripheral neuropathy (7% vs 3%), peripheral sensory neuropathy (3% vs 5%) and hypertension (1% vs 5%).

Conclusion
Adding ipatasertib to paclitaxel did not improve efficacy in PIK3CA/AKT1/PTEN-altered HR+ HER2-negative aBC. The ipatasertib–paclitaxel safety profile was consistent with each agent’s known adverse effects.
Trial registration NCT03337724.
Examining the Mental Health Presentations of Treatment-Seeking Transgender and Gender Nonconforming (TGNC) Youth
Authors: Stewart Shannon L. , Van Dyke Jocelyn N. , Poss Jeffrey W. 
Published: December 2021

AbstractRecent research suggests that transgender and/or gender nonconforming (TGNC) youth present with heightened levels of mental health problems compared to peers. This study seeks to examine the mental health needs of a large sample of treatment-seeking TGNC youth by comparing them to cisgender males and females. Participants were 94,804 children and youth ages 4–18 years (M = 12.1, SD = 3.72) who completed the interRAI Child and Youth Mental Health Instrument (ChYMH) or Screener (ChYMH-S) at participating mental health agencies in the Ontario, Canada. Overall, the mental health presentations of TGNC youth were similar to cisgender females but at higher acuity levels. TGNC youth showed significantly higher levels of anxiety, depression, social disengagement, positive symptoms, risk of suicide/self-harm, and were more likely to report experiencing emotional abuse, past suicide attempts, and a less strong, supportive family relationship than cisgender females and males. Clinical implications of these findings are discussed.
Flow, force, behaviour: assessment of a prototype hydraulic barrier for invasive fish
Authors: Wiegleb Joschka , Hirsch Philipp E. , Seidel Frank , Rauter Georg , Burkhardt-Holm Patricia 
Published: December 2021

AbstractMigration barriers being selective for invasive species could protect pristine upstream areas. We designed and tested a prototype protective barrier in a vertical slot fish pass. Based on the individuals’ swimming responses to the barrier flow field, we assumed this barrier would block the ascension of the invasive round goby, but allow comparable native species (gudgeon and bullhead) to ascend. The barrier was tested in three steps: flow description, quantification of forces experienced by preserved fish in the flow field, and tracking the swimming trajectories of ca. 43 live fish per trial and species. The flow and the forces were homogenous over the barrier, though gudgeon experienced significantly smaller forces than round goby or bullhead. The swimming trajectories were distinct enough to predict the fish species with a random forest machine learning approach (92.16% accuracy for gudgeon and 85.24% for round goby). The trajectories revealed round goby and gudgeon exhibited increased, but varied, swimming speeds and straighter paths at higher water discharge. These results suggest that passage of round goby was prevented at 130 L/s water discharge, whereas gudgeon and bullhead could pass the barrier. Our findings open a new avenue of research on hydraulic constructions for species conservation.
Breast histopathological image analysis using image processing techniques for diagnostic purposes: A methodological review
Authors: Rashmi R , Prasad Keerthana , Udupa Chethana Babu K 
Published: December 2021

AbstractBreast cancer in women is the second most common cancer worldwide. Early detection of breast cancer can reduce the risk of human life. Non-invasive techniques such as mammograms and ultrasound imaging are popularly used to detect the tumour. However, histopathological analysis is necessary to determine the malignancy of the tumour as it analyses the image at the cellular level. Manual analysis of these slides is time consuming, tedious, subjective and are susceptible to human errors. Also, at times the interpretation of these images are inconsistent between laboratories. Hence, a Computer-Aided Diagnostic system that can act as a decision support system is need of the hour. Moreover, recent developments in computational power and memory capacity led to the application of computer tools and medical image processing techniques to process and analyze breast cancer histopathological images. This review paper summarizes various traditional and deep learning based methods developed to analyze breast cancer histopathological images. Initially, the characteristics of breast cancer histopathological images are discussed. A detailed discussion on the various potential regions of interest is presented which is crucial for the development of Computer-Aided Diagnostic systems. We summarize the recent trends and choices made during the selection of medical image processing techniques. Finally, a detailed discussion on the various challenges involved in the analysis of BCHI is presented along with the future scope.
Prompt and delayed gamma rays induced by epithermal and fast neutrons with indium
Authors: Mauerhofer Eric , Ilic Zeljko , Stieghorst Christian , Révay Zsolt , Rossbach Matthias , Li Jingjing , Randriamalala Tsitohaina H. , Brückel Thomas 
Published: December 2021

AbstractThe emission of prompt and delayed gamma rays from (n,γ) and (n,n´γ) reactions induced by irradiation of indium with epithermal and fast neutrons was investigated with the instrument FaNGaS operated at Heinz-Maier-Leibnitz Zentrum (MLZ) in Garching. The average neutron energy of the neutron spectrum was 2.30 MeV. The measurement was done at an angle of 90° between neutron beam and detector. A total of 136 prompt gamma lines from which 42 are related to the capture of epithermal and fast neutrons and 94 to the inelastic scattering of fast neutrons were detected together with the delayed gamma lines of the activation products 113mIn, 114m2In, 115mIn, 116m2In and 116mIn. Intensities and neutron spectrum averaged isotopic partial cross section of the gamma lines are presented. Additionally the neutron spectrum averaged cross sections of the reactions, 113In(n,n´)113mIn, 113In(n,γ)114m2In, 115In(n,n´)15mIn, 115In(n, γ)116m2In and 115In(n, γ)116mIn were determined from the corresponding delayed gamma rays of the formed isotopes as 143 ± 22, 288 ± 13 194 ± 18, 201 ± 10 and 508 ± 24 mb respectively. The various results obtained were found consistent with the literature data. However, our measurement indicate the need to reevaluate the cross section of the 115In(n,γ)116m2In reaction for thermal neutrons.
Train here, drive there: ROS based end-to-end autonomous-driving pipeline validation in CARLA simulator using the NHTSA typology
Authors: Gómez-Huélamo Carlos , Del Egido Javier , Bergasa Luis M. , Barea Rafael , López-Guillén Elena , Arango Felipe , Araluce Javier , López Joaquín 
Published: December 2021

AbstractUrban complex scenarios are the most challenging situations in the field of Autonomous Driving (AD). In that sense, an AD pipeline should be tested in countless environments and scenarios, escalating the cost and development time exponentially with a physical approach. In this paper we present a validation of our fully-autonomous driving architecture using the NHTSA (National Highway Traffic Safety Administration) protocol in the CARLA simulator, focusing on the analysis of our decision-making module, based on Hierarchical Interpreted Binary Petri Nets (HIBPN). First, the paper states the importance of using hyper-realistic simulators, as a preliminary help to real test, as well as an appropriate design of the traffic scenarios as the two current keys to build safe and robust AD technology. Second, our pipeline is introduced, which exploits the concepts of standard communication in robotics using the Robot Operating System (ROS) and the Docker approach to provide the system with isolation, flexibility and portability, describing the main modules and approaches to perform the navigation. Third, the CARLA simulator is described, outlining the steps carried out to merge our architecture with the simulator and the advantages to create ad-hoc driving scenarios for use cases validation instead of just modular evaluation. Finally, the architecture is validated using some challenging driving scenarios such as Pedestrian Crossing, Stop, Adaptive Cruise Control (ACC) and Unexpected Pedestrian. Some qualitative (video files: Simulation Use Cases) and quantitative (linear velocity and trajectory splitted in the corresponding HIBPN states) results are presented for each use case, as well as an analysis of the temporal graphs associated to the Vulnerable Road Users (VRU) cases, validating our architecture in simulation as a preliminary stage before implementing it in our real autonomous electric car.
Benchmarking the Viability of 3D Printed Micromodels for Single Phase Flow Using Particle Image Velocimetry and Direct Numerical Simulations
Authors: Patsoukis Dimou Alexandros , Menke Hannah P. , Maes Julien 
Published: December 2021

AbstractHolistic understanding of multiphase reactive flow mechanisms such as CO2 dissolution, multiphase displacement, and snap-off events is vital for optimisation of large-scale industrial operations like CO2 sequestration, enhanced oil recovery, and geothermal energy. Recent advances in three-dimensional (3D) printing allow for cheap and fast manufacturing of complex porosity models, which enable investigation of specific flow processes in a repeatable manner as well as sensitivity analysis for small geometry alterations. However, there are concerns regarding dimensional fidelity, shape conformity and surface quality, and therefore, the printing quality and printer limitations must be benchmarked. We present an experimental investigation into the ability of 3D printing to generate custom-designed micromodels accurately and repeatably down to a minimum pore-throat size of 140 μm, which is representative of the average pore-throat size in coarse sandstones. Homogeneous and heterogeneous micromodel geometries are designed, then the 3D printing process is optimised to achieve repeatable experiments with single-phase fluid flow. Finally, Particle Image Velocimetry is used to compare the velocity map obtained from flow experiments in 3D printed micromodels with the map generated with direct numerical simulation (OpenFOAM software) and an accurate match is obtained. This work indicates that 3D printed micromodels can be used to accurately investigate pore-scale processes present in CO2 sequestration, enhanced oil recovery and geothermal energy applications more cheaply than traditional micromodel methods.
Mechanical properties of steel slag replaced mineral aggregate for road base/sub-base application based Vietnam and Japan standard
Authors: Dang Dang Tung , Nguyen Manh Tuan , Nguyen Tan Phong , Isawa Tomoo , Ta Yasutaka , Sato Ryoichi 
Published: December 2021

AbstractSteelmaking slag is one of the most massive industrial by-products generated during steelmaking processes. This paper presents the current steelmaking slag production status and its potential to use as mineral aggregates in base/sub-base layer of road pavement. The mechanical properties of steelmaking slag were confirmed by the test method specified in Vietnam specification. The volume stability test of the slag was conducted based on JIS A 5015-2018 (Japanese Industrial Standard: Iron and steel slag for road construction). From the results, it was confirmed that steelmaking slag can satisfy all the mechanical requirements specified in Vietnam specification and the requirements regarding stability specified in JIS A 5015-2018. In addition, it was found that the elastic modulus of steelmaking slag applied as a base or sub-base layer in pavement was higher than that of the conventional graded aggregate made from mineral aggregate. Therefore, the thickness of pavement can be reduced by using steelmaking slag, and the construction cost can be lower.
Acute and chronic health risk assessment for inhalation and ingestion exposure in acrylic acid leak accidents
Authors: Lim Hui-Been , Park Si-Hyun , Hong Hyong-Jin , Jeong Ji-Yun , Kim Hee-Seok , Lee Cheol-Min 
Published: December 2021

AbstractWe established a hypothetical acrylic acid leak accident scenario, conducted a health risk assessment of local residents, and compared an actual accident case to the hypothetical scenario. The exposed subjects were divided into four age groups, and a noncarcinogenic health risk assessment was conducted for inhalation and soil ingestion. In the hypothetical scenario, 40 tons of acrylic acid was leaked in Ulsan for 1 h from midnight on January 1, 2017. In the actual accident case, 3 L of acrylic acid was leaked in Hwaseong, Gyeonggi Province, for 1 h from 11:00 am on March 5, 2020. The environmental concentration of acrylic acid was calculated using the dynamic multimedia environmental model. Noncarcinogenic assessment of the hypothetical scenario showed the hazard quotient exceeded 1 across all age groups, suggesting that a health risk is likely to occur due to inhalation exposure to acrylic acid resulting from a chemical accident. In addition, Hazardacute exceeded 1 until 2 h after the accident under the hypothetical scenario, indicating the likelihood of a health risk. Thus, we propose a methodology that can assess changing concentrations in a hazardous chemical leak from a chemical accident based on the time, place, the chemical’s behaviors in different environmental media, and the health risk posed by the exposure of the chemical to local residents in the area affected by the accident.
A workflow to investigate the impacts of weathered multi-walled carbon nanotubes to the mud snail Lymnaea stagnalis
Authors: Weise Katrin , Kurth Thomas , Politowski Irina , Winkelmann Carola , Schäffer Andreas , Kretschmar Susanne , Berendonk Thomas Ulrich , Jungmann Dirk 
Published: December 2021

Abstract
Although the development and application of nanomaterials is a growing industry, little data is available on the ecotoxicological effects on aquatic organisms. Therefore, we set up a workflow to address the potential uptake of weathered multi-walled carbon nanotubes (wMWCNTs) by a model organism, the pulmonary mud snail Lymnaea stagnalis (L. stagnalis), which plays an important role in the food web. It represents a suitable organism for this approach because as a grazer it potentially ingests large amounts of sedimented wMWCNTs. As food source for L. stagnalis, benthic biofilm was investigated by the use of a transmission electron microscope (TEM) and a scanning electron microscope (SEM) after exposure with wMWCNTs. In addition, isotopic labeling was applied with 14C-wMWCNTs (0.1 mg/L) to quantify fate, behavior, and enrichment of 14C-wMWCNTs in benthic biofilm and in L. stagnalis. Enrichment in benthic biofilm amounted to 529.0 µg wMWCNTs/g dry weight and in L. stagnalis to 79.6 µg wMWCNTs/g dry weight. A bioconcentration factor (BCF) for L. stagnalis was calculated (3500 L/kg). We demonstrate the accumulation of wMWCNTs (10 mg/L) in the digestive tract of L. stagnalis in an effect study. Moreover, the physiological markers glycogen and triglycerides as indicators for the physiological state, as well as the RNA/DNA ratio as growth indicator, were examined. No significant differences between exposed and control animals were analyzed for glycogen and triglycerides after 24 days of exposure, but a decreasing trend is recognizable for triglycerides. In contrast, the significant reduction in the RNA/DNA ratio of L. stagnalis indicated an inhibition of growth with a following recovery after depuration. The described workflow enables a comprehensive determination of the fate and the behavior of wMWCNTs specifically and in general all kinds of CNTs in the aquatic environment and therefore contributes to a holistic risk assessment of wMWCNTs.
A DEA MCDM Approach Applied to ESS8 Dataset for Measuring Immigration and Refugees Citizens’ Openness
Authors: Martín Juan Carlos , Indelicato Alessandro 
Published: December 2021

AbstractThe current refugees’ crisis is undermining the main government coalitions of many countries in the European Union (EU), and tolerant attitudes and open admission policies toward immigrants seem to be part of the recent past history. The dilemma is gaining a lot of media attention as the public and political debate on migration is now playing an important role in all the European elections. Thus, the aim of this paper twofold. First, an analytical tool is developed to measure two synthetic indicators: (1) the citizens’ openness towards immigration for 23 countries—18 EU Countries, plus Iceland, Israel, Norway, Switzerland, and Russia—included in the 2016 European Social Survey; and (2) the citizens’ openness towards immigrants and refugees for 22 countries (same set without Hungary). And second, the effects of political orientation of citizens over the last synthetic indicator (immigrants and refugees) are studied. The approach of Data Envelopment Analysis (DEA) will be adopted here, with the purpose of identifying which countries are more, or less, open to the phenomenon of immigration and refugees. The results show that the Nordic countries and leftist are those which show more openness to immigration and refugees.
To advise and scrutinize the government? Two types of political knowledge, political trust and unconventional participation
Authors: Michalski Piotr , Marchlewska Marta , Furman Aleksandra , Szczepańska Dagmara , Panayiotou Orestis , Molenda Zuzanna , Górska Paulina 
Published: December 2021

AbstractWell-functioning democracies depend on citizens’ ability to make accurate political judgments and express them in the public sphere. Thus, in this research, we aim to better understand the role of political knowledge and political trust in shaping young Poles’ willingness to engage in unconventional participation such as signing a petition, boycotting specific products, taking part in a peaceful demonstration, or engaging in social media activities. We distinguish between two types of political knowledge: knowledge about the rules of the game and current political knowledge, which provide a more insightful look into the complex nature of relationships between political knowledge, political trust, and unconventional participation. In two studies (Study 1, N = 570 and Study 2; N = 1048) we found that unconventional participation was positively predicted by political trust, and political knowledge about the rules of the game. We also found a significant interaction effect between political trust and current political knowledge, suggesting that those high in current political knowledge may be more willing to participate only when being distrustful towards the current political system. Implications and limitations of these findings are discussed.
Prostate-specific membrane antigen and fibroblast activation protein distribution in prostate cancer: preliminary data on immunohistochemistry and PET imaging
Authors: Kessel Katharina , Seifert Robert , Weckesser Matthias , Boegemann Martin , Huss Sebastian , Kratochwil Clemens , Haberkorn Uwe , Giesel Frederik , Rahbar Kambiz 
Published: December 2021

Abstract
Introduction
Fibroblast activation protein (FAP) has been recently presented as new imaging target for malignant diseases and offers high contrast to surrounding normal tissue. FAP tracer uptake has been reported in various tumor entities. The aim of this study was to compare FAP and Prostate-specific membrane antigen (PSMA) expression in primary prostate cancer employing histological analyses and PET imaging in two small patient collectives.

Methods
Two independent small patient collectives were included in this study. For cohort A, data of 5 prostate cancer patients and 3 patients with benign prostate hyperplasia were included. Patients with prostate cancer were initially referred for PSMA PET staging. Radical prostatectomy was performed in all patients and prostate specimen of patients and biopsies of healthy controls were available for further evaluation. Histological workup included HE and immunohistochemistry using PSMA Ab, FAP Ab. Cohort B consists of 6 Patients with diagnosed mCRPC and available PSMA as well as FAP PET.

Results
Patients with proven prostate cancer infiltration exhibited strong positivity for PSMA in both primary tumors and lymph node metastases while stainings for FAP were found positive in some cases, but not all (2/5). Controls with BPH presented moderate PSMA staining and in one case also with a positive FAP staining (1/3). PET imaging with FAP seemed to result in more precise results in case of low PSMA expression than PSMA-PET.

Conclusions
While PSMA staining intensity is a valid indicator of prostate cancer in both primary tumor and lymph node metastases, the expression of FAP seems to be heterogeneous but not necessarily linked to cancer-associated fibroblasts. It is also present in inflammation-associated myofibroblasts. Therefore, its ultimate role in prostate cancer diagnosis remains a subject of discussion.