bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gut bacteria formation and influencing factors
Authors: Yang Jing , Wu Jin'en , Li Yating , Zhang Yong'e , Cho William C , Ju Xianghong , van Schothorst Evert M , Zheng Yadong 
Published: March 2021

ABSTRACT
The gut microbiota plays an important role in human health. In modern life, with the improvement of living conditions, the intake of high-sugar and high-fat diets as well as the large-scale use of antibacterial drugs have an extensive impact on the gut microbiota, even leading to gut microbiota-orchestrating disorders. This review discusses the effects of various factors, including geographic location, age, diet, antibacterial drugs, psychological situation and exercise on gut bacteria, which helps us profoundly to understand the significance of gut bacteria to human health and to find effective solutions to prevent or treat related diseases.
The Association Between Physical Activity Intensity, Cognition, and Brain Structure in People With Type 2 Diabetes
Authors: Zabetian-Targhi Fateme , Srikanth Velandai K , Beare Richard , Breslin Monique , Moran Chris , Wang Wei , Wu Feitong , Smith Kylie J , Callisaya Michele L 
Published: March 2021

AbstractBackgroundPhysical inactivity is a risk factor for type 2 diabetes (T2D) and dementia. However, it is unknown if physical activity (PA) intensity is associated with brain health in people with T2D. Therefore, this study aimed to determine (i) associations between PA intensity and step count with both cognition and brain structure and (ii) if apolipoprotein E-ε4 or insulin therapy modifies any associations.MethodsParticipants were people with T2D (n = 220; aged 55–86 years). An accelerometer worn over the right hip was used to obtain step count and moderate-to-vigorous PA (MVPA) averaged over 7 days. Cognition in 7 domains was obtained using a battery of neuropsychological tests. Brain structure was measured by Magnetic Resonance Imaging. Linear regression models were used to examine associations between step count, MVPA and each cognitive and Magnetic Resonance Imaging measure. Apolipoprotein E-ε4 × PA and insulin therapy × PA product terms were added to the models to examine effect modification.ResultsThe mean age of participants was 67.9 (SD = 6.3). Higher step count was associated with greater hippocampal volume (β = 0.028, 95% CI = 0.005, 0.051). Insulin therapy modified the association between MVPA and attention–processing speed, such that associations were significant in people receiving insulin therapy (p for interaction = .019). There were no other significant associations.ConclusionsHigher step count and greater time spent in MVPA may be associated with better hippocampal volume and attention–processing speed, respectively, in people with T2D. People with greater diabetes severity (receiving insulin therapy) may get more cognitive benefit from MVPA.
Interventions to Improve the Transition From Home to a Nursing Home: A Scoping Review
Authors: Groenvynck Lindsay , Fakha Amal , de Boer Bram , Hamers Jan P H , van Achterberg Theo , van Rossum Erik , Verbeek Hilde 
Published: March 2021

Abstract

Background and Objectives
The transition from home to a nursing home is a stressful event for both older persons and informal caregivers. Currently, this transition process is often fragmented, which can create a vicious cycle of health care-related events. Knowledge of existing care interventions can prevent or break this cycle. This project aims to summarize existing interventions for improving transitional care, identifying their effectiveness and key components.

Research Design and Methods
A scoping review was performed within the European TRANS-SENIOR consortium. The databases PubMed, EMBASE (Excerpta Medica Database), PsycINFO, Medline, and CINAHL (Cumulated Index to Nursing and Allied Health Literature) were searched. Studies were included if they described interventions designed to improve the transition from home to a nursing home.

Results
17 studies were identified, describing 13 interventions. The majority of these interventions focused on nursing home adjustment with 1 study including the entire transition pathway. The study identified 8 multicomponent and 5 single-component interventions. From the multicomponent interventions, 7 main components were identified: education, relationships/communication, improving emotional well-being, personalized care, continuity of care, support provision, and ad hoc counseling. The study outcomes were heterogeneous, making them difficult to compare. The study outcomes varied, with studies often reporting nonsignificant changes for the main outcome measures.

Discussion and Implications
There is a mismatch between the theory on optimal transitional care and current transitional care interventions, as they often lack a comprehensive approach. This research is the first step toward a uniform definition of optimal transitional care and a tool to improve/develop (future) transitional care initiatives on the pathway from home to a nursing home.
Present-day orogenic processes in the western Kalpin nappe explored by interseismic GNSS measurements and coseismic InSAR observations of the 2020Mw 6.1 Kalpin event
Authors: He Ping , Wen Yangmao , Li Shuiping , Ding Kaihua , Li Zhicai , Xu Caijun 
Published: March 2021

SUMMARYAs the largest and most active intracontinental orogenic belt on Earth, the Tien Shan (TS) is a natural laboratory for understanding the Cenozoic orogenic processes driven by the India–Asia collision. On 19 January 2020, a Mw 6.1 event stuck the Kalpin region, where the southern frontal TS interacts with the Tarim basin. To probe the local ongoing orogenic processes and potential seismic hazard in the Kalpin region, both interseismic and instantaneous deformation derived from geodetic observations are used in this study. With the constraint of interseismic global navigation satellite system (GNSS) velocities, we estimate the décollement plane parameters of the western Kalpin nappe based on a 2-D dislocation model, and the results suggest that the décollement plane is nearly subhorizontal with a dip of ∼3° at a depth of 24 km. Then, we collect both Sentinel-1 and ALOS-2 satellite images to capture the coseismic displacements caused by the 2020 Kalpin event, and the interferometric synthetic aperture radar (InSAR) images show a maximum displacement of 7 cm in the line of sight near the epicentral region. With these coseismic displacement measurements, we invert the source parameters of this event using a finite-fault model. We determine the optimal source mechanism in which the fault geometry is dominated by thrust faulting with an E–W strike of 275° and a northward dip of 11.2°, and the main rupture slip is concentrated within an area 28.0 km in length and 10.3 km in width, with a maximum slip of 0.3 m at a depth of 6–8 km. The total released moment of our preferred distributed slip model yields a geodetic moment of 1.59 × 1018 N$ \cdot $m, equivalent to Mw 6.1. The contrast of the décollement plane depth from interseismic GNSS and the rupture depth from coseismic InSAR suggests that a compression still exists in the Kalpin nappe forefront, which is prone to frequent moderate events and may be at risk of a much more dangerous earthquake.
“More than just another physical activity program”: exploring the GUM program for at-risk adolescent girls
Authors: Hargreaves Nicole , Forneris Tanya , Sabiston Catherine , Berg Stephen , Kowalski Kent , Ferguson Leah , Caperchione Cristina 
Published: March 2021

Abstract
Physical activity (PA) levels among adolescent girls continue to steadily decline, especially for those classified as ‘at-risk’. To mitigate these trends, Girls United and on the Move (GUM) was created as a dual-component PA and psychosocial program. The primary purpose of this study was to explore participant experiences within GUM, with a secondary purpose of qualitatively informing future PA programs for ‘at-risk’ adolescent girls. Semi-structured interviews (N = 30) were conducted with a purposeful sample of girls from the GUM program. An inductive thematic analysis was utilized to analyze verbatim transcripts. Two themes were generated from the data: 1) Girls uplifting girls, outlining the importance of a girls-only environment and introducing opportunities for alternative PAs, and 2) finding balance between the physical and psychological, detailing the importance of the dual-component program. These findings provide support for the acceptability of an integrated psychosocial and PA program for at-risk adolescent girls.
Frozen elephant trunk technique with different proximal landing zone for aortic dissection
Authors: Panfilov Dmitri S , Kozlov Boris N , Pryakhin Andrey S , Kopeva Kristina V 
Published: March 2021

Abstract

OBJECTIVES
The objective of the study was to evaluate early and midterm outcomes after the frozen elephant trunk (FET) procedure with different proximal landing zones in patients with aortic dissection.

METHODS
Forty-four patients with type A and type B aortic dissection that extended down to the abdominal aorta were enrolled in the study. All of the patients had the FET procedure. The patients were divided in 2 groups according to the level of the proximal landing zone: the zone 2 (Z2) group and zone 3 (Z3) group. Early and midterm outcomes including the false lumen (FL) thrombosis rate were monitored in both groups.

RESULTS
The incidence of stroke, delirium and spinal cord ischaemia was 5.9% vs 3.7% (P = 0.533), 5.9% vs 7.4% (P = 0.903) and 5.9% vs 0 (P = 0.533) in the Z2 and Z3 groups, respectively. The 30-day mortality was 9.1% in both groups. The mean distal landing zone was T7.5 (T7; T9) in the Z2 group vs T9 (T8; T10) in the Z3 group (P = 0.668). The 2-year overall survival was 62.2% with no significant difference in the Z2 and Z3 groups (61.6% vs 64.2%; P = 0.940). There were no aortic-related deaths during the follow-up period. Freedom from reintervention at 24 months was 73% and was comparable between Z2 and Z3 (74.1% vs 91.7%; P = 0.123). The rate of early complete FL thrombosis was comparable in the Z2 and Z3 groups. By 24 months of observation in the Z3 group, the rate of complete FL thrombosis was significantly higher (60% vs 77%; P = 0.046).

CONCLUSIONS
No statistically significant differences were observed between landing zones 2 and 3 during the FET procedure with regard to early outcomes. Proximalization of the FET was associated with a shorter FL thrombosis in the midterm follow-up period that affected the distal aortic reintervention rate.
Quantitative Uniqueness Properties forL2 Functions with Fast Decaying, or Sparsely Supported, Fourier Transform
Authors: Jaye Benjamin , Mitkovski Mishko 
Published: March 2021

AbstractThis paper builds upon two key principles behind the Bourgain–Dyatlov quantitative uniqueness theorem for functions with Fourier transform supported in an Ahlfors regular set. We first provide a characterization of when a quantitative uniqueness theorem holds for functions with very quickly decaying Fourier transform, thereby providing an extension of the classical Paneah–Logvinenko–Sereda theorem. Secondly, we derive a transference result which converts a quantitative uniqueness theorem for functions with fast decaying Fourier transform to one for functions with Fourier transform supported on a fractal set. In addition to recovering the result of Bourgain–Dyatlov, we obtain analogous uniqueness results for denser fractals.
Human Immunodeficiency Virus/AIDS in the Era of Coronavirus Disease 2019: A Juxtaposition of 2 Pandemics
Authors: Eisinger Robert W , Lerner Andrea M , Fauci Anthony S 
Published: March 2021

Abstract
The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted persons with human immunodeficiency virus (HIV), interfering with critical health services for HIV prevention, treatment, and care. While there are multiple profiles of persons living with HIV and the impact of COVID-19 may differ for each, the severity of COVID-19 in persons with HIV is related strongly to the presence of comorbidities that increase the risk of severe disease in COVID-19 patients in the absence of HIV. An effective response to the juxtaposition of the HIV and COVID-19 pandemics requires a novel coordinated and collaborative global effort of scientists, industry, and community partners to accelerate basic and clinical research, as well as implementation science to operationalize evidence-based interventions expeditiously in real-world settings. Accelerated development and clinical evaluation of prevention and treatment countermeasures are urgently needed to mitigate the juxtaposition of the HIV and COVID-19 pandemics.
Enabling adoption and use of new health information technology during implementation: Roles and strategies for internal and external support personnel
Authors: Umstead Claire N , Unertl Kim M , Lorenzi Nancy M , Novak Laurie Lovett 
Published: March 2021

Abstract

Objective
Successful technological implementations frequently involve individuals who serve as mediators between end users, management, and technology developers. The goal for this project was to evaluate the structure and activities of such mediators in a large-scale electronic health record implementation.

Materials and Methods
Field notes from observations taken during implementation beginning in November 2017 were analyzed qualitatively using a thematic analysis framework to examine the relationship between specific types of mediators and the type and level of support to end users.

Results
We found that support personnel possessing both contextual knowledge of the institution’s workflow and training in the new technology were the most successful in mediation of adoption and use. Those that lacked context of either technology or institutional workflow often displayed barriers in communication, trust, and active problem solving.

Conclusions
These findings suggest that institutional investment in technology training and explicit programs to foster skills in mediation, including roles for professionals with career development opportunities, prior to implementation can be beneficial in easing the pain of system transition.
Effects of cooled floor pads combined with chilled drinking water on behavior and performance of lactating sows under heat stress
Authors: Zhu Y , Johnston L J , Reese M H , Buchanan E S , Tallaksen J E , Hilbrands A H , Li Y Z 
Published: March 2021

Abstract
This study was conducted to evaluate whether cooled floor pads combined with chilled drinking water could alleviate negative impacts of heat stress on lactating sows. Thirty sows (Landrace × Yorkshire, Parity = 1 to 6) were housed in individual farrowing stalls in two rooms with temperatures being controlled at 29.4°C (0700–1900 hours) and 23.9°C (1900–0700 hours). Sows in one room (Cool), but not in the other room (Control) were provided cooled floor pads (21–22°C) and chilled drinking water (13–15°C). Behavior of sows (15 sows/treatment) was video recorded during farrowing, and days 1, 3, 7, 14, and 21 after farrowing. Videos were viewed continuously to register the birth time of each piglet, from which total farrowing duration and birth intervals were calculated. The number of drinking bouts and the duration of each drinking bout were registered for each sow through viewing videos continuously for 2 h (1530–1730 hours) each video-recording day. Postures (lying laterally, lying ventrally, sitting, and standing) were recorded by scanning video recordings at 5-min intervals for 24 h each video-recording day, and time budget for each posture was calculated. Rectal temperature and respiration rate were measured for all sows the day before and after farrowing, and then once weekly. Sow and litter performance was recorded. Data were analyzed using the Glimmix procedure of SAS. The cooling treatment did not affect sow behavior or litter performance. Sows in the Cool room had lower rectal temperature (P = 0.03) and lower respiration rate (P &lt; 0.001), consumed more feed (P = 0.03), tended to have reduced weight loss (P = 0.07), and backfat loss (P = 0.07) during lactation than sows in the Control room. As lactation progressed, sows increased drinking frequency (P &lt; 0.001) and time spent lying ventrally (P &lt; 0.0001), standing (P &lt; 0.001), and sitting (P &lt; 0.0001), and decreased time spent lying laterally (P &lt; 0.0001) in both Cool and Control rooms. While cooled floor pads combined with chilled drinking water did not affect sow behavior, they did alleviate heat stress partially, as indicated by decreased rectal temperature, respiration rate, weight, and backfat loss, and increased feed intake in lactating sows.
Identification of genomic regions that exhibit sexual dimorphism for size and muscularity in cattle
Authors: Doyle Jennifer L , Purfield Deirdre C , Moore Tom , Carthy Tara R , Walsh Siobhan W , Veerkamp Roel F , Evans Ross D , Berry Donagh P 
Published: March 2021

Abstract
Sexual dimorphism, the phenomenon whereby males and females of the same species are distinctive in some aspect of appearance or size, has previously been documented in cattle for traits such as growth rate and carcass merit using a quantitative genetics approach. No previous study in cattle has attempted to document sexual dimorphism at a genome level; therefore, the objective of the present study was to determine whether genomic regions associated with size and muscularity in cattle exhibited signs of sexual dimorphism. Analyses were undertaken on 10 linear-type traits that describe the muscular and skeletal characteristics of both males and females of five beef cattle breeds: 1,444 Angus (AA), 6,433 Charolais (CH), 1,129 Hereford, 8,745 Limousin (LM), and 1,698 Simmental. Genome-wide association analyses were undertaken using imputed whole-genome sequence data for each sex separately by breed. For each single-nucleotide polymorphism (SNP) that was segregating in both sexes, the difference between the allele substitution effect sizes for each sex, in each breed separately, was calculated. Suggestively (P ≤ 1 × 10−5) sexually dimorphic SNPs that were segregating in both males and females were detected for all traits in all breeds, although the location of these SNPs differed by both trait and breed. Significantly (P ≤ 1 × 10−8) dimorphic SNPs were detected in just three traits in the AA, seven traits in the CH, and three traits in the LM. The vast majority of all segregating autosomal SNPs (86% in AA to 94% in LM) had the same minor allele in both males and females. Differences (P ≤ 0.05) in allele frequencies between the sexes were observed for between 36% (LM) and 66% (AA) of the total autosomal SNPs that were segregating in both sexes. Dimorphic SNPs were located within a number of genes related to muscularity and/or size including the NAB1, COL5A2, and IWS1 genes on BTA2 that are located close to, and thought to be co-inherited with, the MSTN gene. Overall, sexual dimorphism exists in cattle at the genome level, but it is not consistent by either trait or breed.
Effects of iron injection timing on suckling and subsequent nursery and growing-finishing performance and hematological criteria
Authors: Williams Hayden E , Carrender Brittany , Roubicek Cierra D , Maurer Ryan , DeRouchey Joel M , Woodworth Jason C , Dritz Steve S , Tokach Michael D , Coble Kyle F , Goodband Robert D , Gebhardt Jordan T 
Published: March 2021

AbstractTwo experiments were conducted to evaluate the effects of Fe injection timing after birth on suckling and subsequent nursery and growing-finishing pig performance. The injectable Fe source used in both experiments was GleptoForte (Ceva Animal Health, LLC., Lenexa, KS). GleptoForte contains gleptoferron which is a Fe macromolecule complex. In Exp. 1, a total of 324 newborn pigs (DNA 241 × 600, initially 1.6 ± 0.04 kg body weight [BW]) within 27 litters were used. Two days after birth, all piglets were weighed, and six barrows and six gilts per litter were allotted to 1 of 6 treatments consisting of no Fe injection or 200 mg of injectable Fe provided in a single injection on d 2, 4, 6, 8, or 10 of age. Pigs were weaned (~21 d of age) and allotted to nursery pens with all pigs in each pen having received the same Fe treatment. In Exp. 2, a total of 1,892 newborn pigs (PIC 359 × C40; initially 1.5 ± 0.02 kg BW) within 172 litters were used. One day after birth, piglets were weighed, and 11 pigs within each litter were allotted to 1 of 6 treatments consisting of no Fe injection or 200 mg of injectable Fe provided on d 1, 3, 5, or 7 of age, or 200 mg on d 1 plus 200 mg on d 12 of age. Pigs were weaned (19 d of age) and placed in a commercial wean-to-finish facility in a total of 15 pens with equal representation of treatments in each pen. In both experiments, not providing an Fe injection after birth decreased (P &lt; 0.05) preweaning average daily gain (ADG), weaning weight, and hemoglobin and hematocrit values compared with all other treatments. In Exp. 1, increasing the age that piglets received an Fe injection until 4 or 6 d after birth provided marginal evidence for an improvement (quadratic; P = 0.070) in preweaning ADG. For the nursery period, increasing the age that piglets received an Fe injection improved (quadratic; P = 0.013) d 80 BW, but there was no evidence of a difference (P &gt; 0.10) in d 173 BW at the end of the grow-finish period. In Exp. 2, increasing the age that piglets received a 200 mg Fe injection showed no evidence of difference (P &gt; 0.10) for subsequent nursery and growing-finishing ADG. In both experiments, hemoglobin and hematocrit values were decreased (linear; P &lt; 0.05) at weaning with increasing age when pigs received an Fe injection. These experiments suggest that providing a 200 mg Fe injection within 7 d after farrowing is sufficient for optimizing preweaning and subsequent growth performance.