bluuebunny/crossref_metadata_2025_split huggingface dataset:
When Inspiratory Stridor Is Not Paradoxical Vocal Fold Motion/Inducible Laryngeal Obstruction: A Case Study of Diaphragm Flutter
Authors: Sandage Mary J. , Billingsley C. P. , Hatcher Jeanne L. , Petty Brian , Olin J. Tod 
Published: June 2021

Purpose
This case study describes the clinical course for an individual referred to a speech-language pathologist (SLP) for assessment and treatment of paradoxical vocal fold motion/inducible laryngeal obstruction (PVFM/ILO) who was ultimately diagnosed with diaphragm flutter. This case presentation describes the critical importance of a multidisciplinary approach to identify conditions in the differential diagnosis of PVFM/ILO, which may lead to timely diagnosis and treatment of such conditions.

Method
Using a case study format with links to pre- and posttreatment videos, the clinical course of a 20-year-old woman presenting with persistent inspiratory stridor and cough during waking time was delineated. Data used to determine the differential diagnosis included careful clinical observation, extensive medical history, and endoscopic laryngeal assessment.

Results
Using a multidisciplinary approach with professionals from three different treatment centers, the diagnosis of diaphragm flutter was affirmed and successful medical management with an empiric trial of Baclofen was initiated with complete resolution of the dyspnea, cough, and inspiratory stridor over 3 weeks.

Conclusions
This case study describes a rare condition in the differential diagnosis of PVFM/ILO called diaphragm flutter, characterized by persistent inspiratory stridor and cough that interrupted connected speech and swallowing. SLPs who specialize in the assessment and treatment of PVFM/ILO may encounter this condition. Clinician awareness of the clinical profile for diaphragm flutter is critical for rapid referral to the appropriate medical specialists to achieve timely symptom relief.

Supplemental Material

https://doi.org/10.23641/asha.14781867
Dark matter fraction in z  ∼  1 star-forming galaxies
Authors: Sharma Gauri , Salucci Paolo , van de Ven Glenn 
Published: June 2021

Context. The study of dark matter (DM) across cosmic timescales is essential for understanding galaxy formation and evolution. Recent observational studies show that further back in time (z > 0.5), rotation-supported, star-forming galaxies (SFGs) begin to appear to be DM deficient compared to local SFGs.
Aims. We present an observational study of the DM fraction in 225 rotation-supported, SFGs at z ≈ 0.9; these SFGs have stellar masses in the range 9.0 ≤ log(M* M⊙) ≤ 11.0 and star formation rates 0.49 ≤ log(SFR[M⊙ yr−1]) ≤ 1.77.
Methods. We studied a subsample of the KMOS Redshift One Spectroscopic Survey (KROSS) studied by Sharma et al. (2021, MNRAS, 503, 1753). The stellar masses (M*) of these objects were previously estimated using mass-to-light ratios derived from fitting the spectral energy distribution of the galaxies. Star formation rates were derived from the Hα luminosities. In this paper, we determined the total gas masses (Mgas) by the scaling relations of molecular and atomic gas (Tacconi et al. 2018, ApJ, 853, 179; Lagos et al. 2011, MNRAS, 418, 1649, respectively). We derived the dynamical masses (Mdyn) from the rotation curves (RCs) at different scale lengths (effective radius: Re, ∼2 Re and ∼3 Re) and we then calculated the DM fractions (fDM = 1 − Mbar/Mdyn) at these radii.
Results. We report that at z ∼ 1 only a small fraction (∼5%) of our sample has a low (<20%) DM fraction within ∼2 − 3Re. The majority (>72%) of SFGs in our sample have outer disks (∼5−10 kpc) dominated by DM, which agrees with local SFGs. Moreover, we find a large scatter in the fraction of DM at a given stellar mass (or circular velocity) with respect to local SFGs, suggesting that galaxies at z ∼ 1 span a wide range of stages in the formation of stellar disks and have diverse DM halo properties coupled with baryons.
Assessment of urban planning concepts for the development of post-industrial cities
Authors: Grishina Maria , Medyanik Yulia , Rakhmatullina Elena , Matveeva Elena , Albina Khayrullina 
Published: June 2021

This article is devoted to an overview study of the implemented concepts of the development of modern post-industrial cities. In the study of the issue of the feasibility of the implemented concepts, many domestic and foreign publications on the research topic are given.The authors of this article made an attempt to predict the possible results of the realization of the implemented concepts of the development of post-industrial cities in the long term of their development. The chosen goal is achieved by solving the following tasks:to compare the strategies of urban development being implemented;to identify the signs of an industrial and post-industrial city;identify the strengths and weaknesses of the concepts;describe the positive and negative consequences after the implementation of the concepts of sustainable development of post-industrial cities.
Investigation of the effect of moisture on the critical parameters of stability of frame-rod structural systems made of wood
Authors: Dubrakova Ksenia , Solodilova Victoriia 
Published: June 2021

The work of end moments and shear forces is taken as a criterion influencing the value of the limiting compressive force. It was found that the form of bifurcation of an individual element (active or passive) has a significant effect on the value of the critical parameters of stability of the entire system as a whole.
A frame-rod structural system made of wood is considered. The influence of humidity on the type of bifurcation of its compressed elements (constrained or forced) and the critical parameters of stability of the system as a whole under various modes of force loading are determined. It is shown that with a change in humidity, individual elements can go from passive loss of stability to active, which will change the value of the critical force by an average of 20 %.
To check the obtained analytical dependencies, experimental tests of frame-bar structures made of wood were carried out under their power static loading and variable humidity. At the same time, it was noted that the results of numerical and laboratory studies showed satisfactory agreement, on average by 95 %, which indicates the reliability of the developed methodology.
Dosha im Überschuss?
Authors: Nagersheth Kalyani 
Published: June 2021

SummaryDoshas – Vata, Pitta und Kapha – gelten in der ayurvedischen Medizin als potenziell krankmachende Tendenzen, die entsprechend der individuellen Konstitution dominieren, Erkrankungen begünstigen und therapeutisch reguliert werden können. Gesunde Körperfülle, Verdauungsfeuer, guter Schlaf, maßvolle Sinnesreize, Achtsamkeit und Willenskraft zählen zu den zentralen Größen für ein ausbalanciertes Leben. Im vorgestellten Fall konnte die ayurvedische Therapie eine Patientin mit Anorexia nervosa, Erschöpfungssyndrom und Insomnie stabilisieren.
Zum Schutz von Nieren und Gelenken
Authors: März Henrike 
Published: June 2021

SummaryInfolge zu hoher Harnsäurekonzentrationen im Blut kann es zu Ablagerungen von Harnsäurekristallen in Gelenken und Organen kommen. Ernährungstherapeutische Maßnahmen können die exogene Purinbelastung reduzieren und die Harnsäureausscheidung fördern. Ovo-lakto-vegetabile Kost und bei Übergewicht eine allmähliche Gewichtsreduktion haben sich zur Senkung erhöhter Harnsäurewerte bewährt.
Lust ohne Liebe
Authors: Textor Reinhard 
Published: June 2021

SummarySexualität verlagert sich immer schneller in die technische Welt der Pornografie, Spielzeuge und Dating-Apps, wo sie echte partnerschaftliche Intimität zunehmend verdrängt. Aus lustvoller Liebe wird lieblose Lust und schließlich lustlose Sucht – bis hin zu Selbstwertkrisen und der Unmöglichkeit echter sexueller Begegnung. Zu den wichtigsten Therapieschritten zählen Aussprache, Aufklärung, Suchtkontrolle und Ursachenforschung, um Lebensgestaltung und Selbstentwicklung wieder zurückzuerobern.
Hormon-Hunger!?
Authors: Miorin-Bellermann Juliane 
Published: June 2021

SummaryEin Ungleichgewicht im Zusammenwirken von Hunger, Appetit und Sättigung kann nicht nur Gewichtsprobleme auslösen, sondern auch die Krankheitsdynamik von Essstörungen befeuern. Nicht selten kommt eine Hormondysbalance als (Mit)Ursache infrage. Hier können verschiedenste Hormone diagnostisch ausschlaggebend sein: angefangen von z. B. Leptin, Ghrelin und DHEA über Steroidhormone bis hin zu Serotonin und Melatonin. Die hormonbezogene Behandlung innerhalb der multimodalen Therapie umfasst Lebensstiländerungen, die Substitution von Hormonbausteinen und die Gabe von hormondrüsenstimulierenden und -rhythmisierenden Mitteln.
A mural that helped to bring down Jeremy Corbyn
Authors: Teubert Wolfgang 
Published: June 2021

Abstract
In the 2017 elections, the Labour party under Jeremy Corbyn did much better than expected, in spite of being
denounced by the established British media for its radical anti-capitalist agenda. To turn the tables, the media then shifted
their attack from this political programme to Corbyn’s alleged blindness towards antisemitic manifestations. The resulting loss of
sympathy with voters cost Labour dearly in the 2019 elections and brought his leadership to an end. As key evidence for his moral
failure to tackle the antisemitism issue, the media cited, in a barrage of pieces, his 2012 comments on a short lived London
mural. Was it anti-capitalist or antisemitic? In the absence of any serious dialogue between contrary views, the judgment passed
reasserted the underlying media agenda.
Class-Specific Relationship Between Use of Immunosuppressants and Risk for Community-Acquired Clostridioides difficile Infection
Authors: Varma Sanskriti , Greendyke William G , Li Jianhua , Freedberg Daniel E 
Published: June 2021

Abstract

Background
Immunosuppressant exposure is associated with risk for Clostridioides difficile infection (CDI). It is unknown whether this risk is shared equally across immunosuppressant classes.

Methods
This was a retrospective cohort study. Adults were included if they were tested for community-acquired CDI (CA-CDI) by stool polymerase chain reaction within 72 hours of hospitalization between 2010 and 2019. The primary outcome was CA-CDI requiring hospitalization, defined as a positive stool test. The primary exposure was use of a home immunosuppressant, at any dose or duration, defined based on the medication reconciliation, and categorized as systemic steroids, calcineurin inhibitors, antimetabolites, anti–tumor necrosis factor-alpha agents, anti-CD20 antibody, and all others.

Results
A total of 10 992 hospitalized patients met criteria for the study including 1793 (16%) with CA-CDI; 23% used 1 or more immunosuppressant class. Among those immunosuppressed, 27% tested positive for CA-CDI compared with 22% among those who were not immunosuppressed (P &lt; .01). After adjustment, calcineurin inhibitors (adjusted odds ratio [aOR], 1.19; 95% confidence interval [CI], 1.01–1.44) were associated with increased risk for CA-CDI. Risk for CA-CDI rose with multiple immunosuppressant classes: aOR, 1.22; aOR, 1.53; and aOR, 2.40 for 2, 3, and 4 classes, respectively. After excluding those with solid organ transplant, the relationship between use of calcineurin inhibitors and CDI increased (aOR, 2.21; 95% CI, 1.40–3.49).

Conclusions
The greatest risk for CA-CDI was observed among patients using multiple classes of immunosuppressants and those using calcineurin inhibitors. Future studies should recognize that CDI risk differs based on immunosuppressant class.
Eco-audit of conventional heart surgery procedures
Authors: Grinberg Daniel , Buzzi Rémi , Pozzi Matteo , Schweizer Rémi , Capsal Jean-Fabien , Thinot Bergamotte , Quyen Le Minh , Obadia Jean-Francois , Cottinet Pierre-Jean 
Published: June 2021

ABSTRACT OBJECTIVESHealthcare systems have a significant environmental impact and, thus, indirectly affect public health. In order to improve current practices, a better understanding of the actual environmental impact generated by surgical procedures is necessary.METHODSAn eco-audit methodology was carried out to assess the greenhouse gas emissions arising from conventional isolated cardiac surgery procedures. This inquiry took into account 3 workstations (the surgical, the anaesthesia and the cardiopulmonary bypass workstations). All wastes were analysed including the disposable medical products, pharmaceuticals and energy consumption during such surgeries.RESULTSTwenty-eight cardiac surgeries were analysed out of a 4-week study period. The mean emissions during a single cardiac surgery was 124.3 kg of carbon dioxide equivalent (CO2-e). Eighty-nine per cent of the total emissions was related to the use of disposable medical products. The environmental impact of pharmaceuticals used at anaesthesia workstations was 12.4 kg of CO2-e (10% of total greenhouse gas emission), with 11.1 kg of CO2-e resulting from the use of halogenated gas. Direct electrical consumption resulted in 4.0 kg of CO2-e per surgery (3% of all emission), including lighting and air conditioning.CONCLUSIONSConventional isolated cardiac procedures yield the global warming equivalent of a 1080 km plane ride for a single passenger. The environmental impact of such life-saving interventions, therefore, must be put in perspective alongside pollution induced by ‘non-indispensable’ human activities. However, numerous initiatives at the local and individual level as well as at a larger systemic and countrywide scale appear to provide accessible pathways to meaningfully reduce greenhouse gas emissions during cardiac surgery.
Dissolved organic matter (DOM) quality drives biogeographic patterns of soil bacterial communities and their association networks in semi-arid regions
Authors: Huang Muke , Chai Liwei , Jiang Dalin , Zhang Mengjun , Jia Weiqian , Huang Yi , Zhou Jizhong 
Published: June 2021

ABSTRACTIt is of great interest to elucidate the biogeographic patterns of soil microorganisms and their driving forces, which is fundamental to predicting alterations in microbial-mediated functions arising from environment changes. Although dissolved organic matter (DOM) represents an important resource for soil microorganisms, knowledge of how its quality affects microbial biogeography is limited. Here, we characterized soil bacterial communities and DOM quality in 45 soil samples collected from a 1500-km sampling transect through semi-arid regions in northern China which are currently suffering great pressure from climate change, using Illumina Miseq sequencing and fluorescence spectroscopy, respectively. We found that DOM quality (i.e. the source of DOM and the humification degree of DOM) had profound shaping influence on the biogeographic patterns exhibited by bacterial diversity, community composition and association networks. Specifically, the composition of bacteria community closely associated with DOM quality. Plant-derived DOM sustained higher bacterial diversity relative to microbial-derived DOM. Meanwhile, bacterial diversity linearly increased with increasing humification degree of DOM. Additionally, plant-derived DOM was observed to foster more complex bacterial association networks with less competition. Together, our work contributes to the factors underlying biogeographic patterns not only of bacterial diversity, community composition but also of their association networks and reports previously undocumented important role of DOM quality in shaping these patterns.
The surface bacterial community of an Australian kelp shows cross-continental variation and relative stability within regions
Authors: Phelps Charlie M , McMahon Kathryn , Bissett Andrew , Bernasconi Rachele , Steinberg Peter D , Thomas Torsten , Marzinelli Ezequiel M , Huggett Megan J 
Published: June 2021

AbstractEpiphytic microbial communities often have a close relationship with their eukaryotic host, assisting with defence, health, disease prevention and nutrient transfer. Shifts in the structure of microbial communities could therefore have negative effects on the individual host and indirectly impact the surrounding ecosystem, particularly for major habitat-forming hosts, such as kelps in temperate rocky shores. Thus, an understanding of the structure and dynamics of host-associated microbial communities is essential for monitoring and assessing ecosystem changes. Here, samples were taken from the ecologically important kelp, Ecklonia radiata, over a 17-month period, from six different sites in two distinct geographic regions (East and West coasts of Australia), separated by ∼3,300 kms, to understand variation in the kelp bacterial community and its potential environmental drivers. Differences were observed between kelp bacterial communities between the largely disconnected geographical regions. In contrast, within each region and over time the bacterial communities were considerably more stable, despite substantial seasonal changes in environmental conditions.
Wood Volume ofEucalyptusClones Established Under Different Spacings in the Brazilian Cerrado
Authors: André Jéssica L , Oliveira Rodrigo de S , Sette Carlos R , Alfenas Acelino C , Zauza Edival Ângelo V , de Siqueira Leandro , Novaes Evandro 
Published: June 2021

AbstractEucalyptus plantations are expanding in Brazil to meet growing demands for wood-based products, such as pulp, paper, and bioenergy. New clones and silvicultural adjustments are needed with the advance of eucalypts to new regions within Brazil. This study’s objective was to evaluate the effect of variable spacing on the development of six Eucalyptus clones cultivated in the Cerrado region of Brazil. These clones were evaluated in a systematic design, with 23 spacing treatments and five biological replicates. Spacing per tree ranged from 1.20 m2 to 21 m2. At two, four, and six years after planting, diameter at breast height (DBH) and height of all trees were measured to estimate wood volume. Regression models were fitted for each trait (DBH, height, and wood volume) and showed that DBH growth was positively affected by spacing, especially at four and six years after planting (R2 &gt; 0.58). Consequently, estimates of individual volume per tree also had a positive relationship with spacing. Total stand volume, on the other hand, was higher under densest spacings. The GG100 clone outperformed all other clones, with higher stand wood volume, especially under the densest spacings. The CCL55 clone is a promising genotype, especially under dense plantations.
Chromosome-level genome assembly of the blue crab,Callinectes sapidus
Authors: Bachvaroff Tsvetan R , McDonald Ryan C , Plough Louis V , Chung J Sook 
Published: June 2021

AbstractThe blue crab, Callinectes sapidus (Rathbun, 1896) is an economically, culturally, and ecologically important species found across the temperate and tropical North and South American Atlantic coast. A reference genome will enable research for this high-value species. Initial assembly combined 200× coverage Illumina paired-end reads, a 60× 8 kb mate-paired library, and 50× PacBio data using the MaSuRCA assembler resulting in a 985 Mb assembly with a scaffold N50 of 153 kb. Dovetail Chicago and HiC sequencing with the 3d DNA assembler and Juicebox assembly tools were then used for chromosome scaffolding. The 50 largest scaffolds span 810 Mb are 1.5–37 Mb long and have a repeat content of 36%. The 190 Mb unplaced sequence is in 3921 sequences over 10 kb with a repeat content of 68%. The final assembly N50 is 18.9 Mb for scaffolds and 9317 bases for contigs. Of arthropod BUSCO, ∼88% (888/1013) were complete and single copies. Using 309 million RNAseq read pairs from 12 different tissues and developmental stages, 25,249 protein-coding genes were predicted. Between C. sapidus and Portunus trituberculatus genomes, 41 of 50 large scaffolds had high nucleotide identity and protein-coding synteny, but 9 scaffolds in both assemblies were not clear matches. The protein-coding genes included 9423 one-to-one putative orthologs, of which 7165 were syntenic between the two crab species. Overall, the two crab genome assemblies show strong similarities at the nucleotide, protein, and chromosome level and verify the blue crab genome as an excellent reference for this important seafood species.
U-Limb: A multi-modal, multi-center database on arm motion control in healthy and post-stroke conditions
Authors: Averta Giuseppe , Barontini Federica , Catrambone Vincenzo , Haddadin Sami , Handjaras Giacomo , Held Jeremia P O , Hu Tingli , Jakubowitz Eike , Kanzler Christoph M , Kühn Johannes , Lambercy Olivier , Leo Andrea , Obermeier Alina , Ricciardi Emiliano , Schwarz Anne , Valenza Gaetano , Bicchi Antonio , Bianchi Matteo 
Published: June 2021

Abstract

Background
Shedding light on the neuroscientific mechanisms of human upper limb motor control, in both healthy and disease conditions (e.g., after a stroke), can help to devise effective tools for a quantitative evaluation of the impaired conditions, and to properly inform the rehabilitative process. Furthermore, the design and control of mechatronic devices can also benefit from such neuroscientific outcomes, with important implications for assistive and rehabilitation robotics and advanced human-machine interaction. To reach these goals, we believe that an exhaustive data collection on human behavior is a mandatory step. For this reason, we release U-Limb, a large, multi-modal, multi-center data collection on human upper limb movements, with the aim of fostering trans-disciplinary cross-fertilization.

Contribution
This collection of signals consists of data from 91 able-bodied and 65 post-stroke participants and is organized at 3 levels: (i) upper limb daily living activities, during which kinematic and physiological signals (electromyography, electro-encephalography, and electrocardiography) were recorded; (ii) force-kinematic behavior during precise manipulation tasks with a haptic device; and (iii) brain activity during hand control using functional magnetic resonance imaging.
StoatyDive: Evaluation and classification of peak profiles for sequencing data
Authors: Heyl Florian , Backofen Rolf 
Published: June 2021

Abstract

Background
The prediction of binding sites (peak-calling) is a common task in the data analysis of methods such as cross-linking immunoprecipitation in combination with high-throughput sequencing (CLIP-Seq). The predicted binding sites are often further analyzed to predict sequence motifs or structure patterns. When looking at a typical result of such high-throughput experiments, the obtained peak profiles differ largely on a genomic level. Thus, a tool is missing that evaluates and classifies the predicted peaks on the basis of their shapes. We hereby present StoatyDive, a tool that can be used to filter for specific peak profile shapes of sequencing data such as CLIP.

Findings
With StoatyDive we are able to classify peak profile shapes from CLIP-seq data of the histone stem-loop-binding protein (SLBP). We compare the results to existing tools and show that StoatyDive finds more distinct peak shape clusters for CLIP data. Furthermore, we present StoatyDive’s capabilities as a quality control tool and as a filter to pick different shapes based on biological or technical questions for other CLIP data from different RNA binding proteins with different biological functions and numbers of RNA recognition motifs. We finally show that proteins involved in splicing, such as RBM22 and U2AF1, have potentially sharper-shaped peaks than other RNA binding proteins.

Conclusion
StoatyDive finally fills the demand for a peak shape clustering tool for CLIP-Seq data that fine-tunes downstream analysis steps such as structure or sequence motif predictions and that acts as a quality control.