bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complex therapy for patients with ankylosing spondylitis with mixed anxiety–depressive disorder
Authors: Blaginina I. I. 
Published: March 2021

Objective. The study aimed to evaluate the effect of therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) in combination with melatonin on the dynamics of the quality of life (QOL), clinical and laboratory activity, and mixed anxiety– depressive disorder (MADD) in patients with ankylosing spondylitis (AS).Materials and methods. The study involved 65 patients with AS and RTDS. Patients from Group I (n=32) were prescribed melatonin at a dose of 3 mg per day at night, 30–40 minutes before bedtime, in addition to standard AS therapy. Patients from Group II (n = 33) received standard therapy. 8 weeks after, the dynamics of QOL indicators, clinical and laboratory activity, and the severity of MADD in patients from both groups were evaluated.Results. The application of melatonin in addition to standard therapy in patients with AS and MADD provided a statistically significant improvement in the functional and clinical-laboratory data (frequency and severity of anxiety and depression, pain syndrome indicators, ESR, CRP, integrative indicators of physical and psychological components of health).Conclusion. The application of melatonin in complex therapy for patients with AS and MADD contributes to the improvement of clinical and laboratory parameters, psychoemotional state, and QOL of this category of patients.
Daily periodicity of labor in pregnant women in physiological and complicated pregnancy depending on the sex of the fetus
Authors: Botasheva T. L. , Andreeva V. O. , Lebedenko E. Yu. , Fabricant A. D. , Khloponina A. V. , Zheleznyakova E. V. , Zavodnov O. P. 
Published: March 2021

Objective: the study aimed to reveal the daily periodicity of labor, the nature of melatonin metabolism, and the outcome of childbirth in women with a physiological and complicated pregnancy, depending on the sex of the fetus.Materials and methods: to study the chronophysiological characteristics of birth outcomes depending on fetal sex, 1 980 birth histories and stories of newborns were analyzed. The neonates were born between January 1 and December 31, 2016, in a maternity ward of the Federal State Budgetary Educational Institution of Higher Education “RostGMU” of the Ministry of Health of Russia. Melatonin production was identified by the level of urinary excretion of 6-sulfatoxymelatonin (6-SM) (its main metabolite) examining the morning portion of the urine of women by the ELISA method (at 8 am 3 ml of urine were collected in Eppendorf tube).Results: it was revealed that fetal sex modulated the activity of the central regulatory mechanisms responsible for the daily period functional processes in the female body and the initiation of labor. The largest number of spontaneous births by male fetuses occurred in the early evening before midnight when daily illumination was decreased, while the birth of girls was observed more often in the period from midnight to early morning. At the same time, mothers of boys had lower production of melatonin compared to that of girls’ mothers.Conclusions. The peculiarities of labor and birth complications associated with the sex of the fetus were identified.
Discoordination of the processes of activation and suppression of immunocompetent cells during mesotherapy with hyaluronic acid
Authors: Sizyakina L. P. , Sergeeva A. I. , Andreeva I. I. 
Published: March 2021

Objective. The study aimed to assess the dynamics of the systemic immune response in patients during mesotherapy with hyaluronic acid (HA).Materials and methods. The observation group included 26 women who received the first-time mesocorrection with drugs based on hyaluronic acid (HA). Injections of low molecular weight HA were carried out according to standard methods in a course of 5 procedures with an interval of 14 days. The parameters of the innate and adaptive immune response were studied before and two weeks after the end of the course. The skin condition was assessed by dermatoscopy (Aramo Smart Lite 300, Southern Korea).Results. The clinical effect of the course of procedures was reflected in the subjective improvement in the appearance. The improvement was confirmed by hardware analysis, which recorded an increase in hydration, a smoothing of the skin relief, and a decrease in the depth of wrinkles. At the end of the course, redistribution of lymphocyte populations towards natural killer cells and B-lymphocytes was revealed with a decrease in the total number of T cells. The antibody production of immunoglobulins of classes M and G was increased, the serum content of Ig A and IgE was reduced, the number of both T-effectors and T-lymphocytes with immunosuppressive activity increased. Changes in the neutrophil system were characterized by the inhibition of the production of reactive oxygen intermediates; the dynamics of the expression of Toll-like receptors by monocytes was ambiguous.Conclusion. The results of the study confirmed the active involvement of the factors of innate and adaptive systemic response in the cosmetic effect, which manifested itself immediately after mesotherapy as systemic dysregulatory immune changes.
Commercially Available Apps to Support Healthy Family Meals: User Testing of App Utility, Acceptability, and Engagement
Authors: Mauch Chelsea E , Laws Rachel A , Prichard Ivanka , Maeder Anthony J , Wycherley Thomas P , Golley Rebecca K 
Published: March 2021

Background
Parents juggling caregiving and paid employment encounter a range of barriers in providing healthy food to their families. Mobile apps have the potential to help parents in planning, purchasing, and preparing healthy family food. The utility and acceptability of apps for supporting parents are unknown. User perspectives of existing technology, such as commercially available apps, can guide the development of evidence-based apps in the future.

Objective
This study aims to determine the feasibility of existing commercially available apps for supporting the healthy food provision practices of working parents.

Methods
Working parents (N=133) were recruited via the web and completed a 10-item Capability, Opportunity, Motivation, and Behavior (COM-B) self-evaluation survey assessing their needs in relation to the provision of healthy family meals. A total of 5 apps were selected for testing, including a meal planning app, recipe app, recipe manager app, family organizer app, and barcode scanning app. Survey items were mapped to app features, with a subsample of parents (67/133, 50.4%) allocated 2 apps each to trial simultaneously over 4 weeks. A semistructured interview exploring app utility and acceptability and a web-based survey, including the System Usability Scale and the user version of the Mobile App Rating Scale, followed app testing. The interview data were analyzed using a theoretical thematic approach.

Results
Survey participants (N=133; mean age 34 years, SD 4 years) were mainly mothers (130/133, 97.7%) and partnered (122/133, 91.7%). Participants identified a need for healthy recipes (109/133, 82% agreed or strongly agreed) and time for food provision processes (107/133, 80.5%). Engagement quality was the lowest rated domain of the user version of the Mobile App Rating Scale across all 5 apps (mean score per app ranging from 3.0 to 3.7 out of a maximum of 5). The family organizer, requiring a high level of user input, was rated the lowest for usability (median 48, IQR 34-73). In the interviews, participants weighed the benefits of the apps (ie, time saving) against the effort involved in using them in determining their acceptability. Organization was a subtheme emerging from interviews, associated with the use of meal planners and shopping lists. Meal planners and shopping lists were used in time, while behavior was occurring.

Conclusions
Meal planning apps and features promoting organization present feasible, time-saving solutions to support healthy food provision practices. Attention must be paid to enhancing app automation and integration, as well as recipe and nutrition content, to ensure that apps do not add to the time burden of food provision and are supportive of healthy food provision behavior in time.
Aplikasi Monitoring Tender Project Dengan Metode Prototyping (Studi Kasus : PT Sinergy Informasi Pratama)
Authors: Maulana Ilham , Prihandi Ifan 
Published: March 2021

PT Sinergy Informasi Pratama merupakan salah satu perusahaan Sistem Integrator yang menyediakan produk dan layanan Teknologi Informasi dan Komunikasi (TIK) khususnya di bidang Informasi Teknologi. PT Sinergy Informasi Pratama memiliki beberapa masalah diantaranya tidak adanya sistem yang memantau perkembangan tender project, pencatatan keikut sertaan tender dan begitu juga dalam penomoran suatu tender. Setiap tender memiliki penomoran dan penomoran tersebut dinamakan dengan sebutan lead. Oleh karena itu diusulkan pembuatan sebuah aplikasi yang dapat memecahkan masalah tersebut. Dalam jurnal ini, penulis mencoba mengusulkan dan membuat sistem aplikasi monitoring tender project berbasis web untuk membantu dalam proses bisnis dan operasional di dalam perusahaan dengan dibantu metode analisa PIECES dan metode pengembangan prototyping. Dengan ini diharapkan informasi menjadi lebih akurat sehingga membantu dalam pengambilan keputusan.
Perancangan Arsitektur Microservices Untuk Resiliensi Sistem Informasi Perpustakaan Pusat (Studi Kasus UPN Veteran Jakarta)
Authors: Garindra Alif , Wati Theresia , Widi P I Wayan 
Published: March 2021

Sebuah sistem informasi yang baik, selain memberikan kemudahan dalam melayani informasi, namun juga tahan akan adanya gangguan. Akhir ini sedang marak sebuah arsitektur yang dipercaya dapat memberikan kemudahan dalam scalability,agility,resiliency,manageability. Arsitektur tersebut adalah arsitektur microservice, dirancang untuk membagi service lebih kecil dan terstruktur guna meningkatkan kualitas sistem informasi. Pada sistem informasi perpustakaan pusat di Universitas Pembangunan Nasional “Veteran” Jakarta, arsitektur ini belum digunakan dan masih menggunakan arsitektur monolitik. Yaitu sebuah arsitektur yang semua komponen dibuat menjadi sebuah kesatuan. Artinya untuk pengembangan, pemeliharaan, dan resiliensi dari sistem tersebut akan lebih sulit dan memakan waktu karena dalam proses pengkodingan frontend dan backend di satu services yang sama. Untuk menjawab permasalahan yang telah disebutkan, peneliti ingin merancang arsitektur microservice yang akan digunakan dalam sistem informasi perpustakaan pusat dengan menggunakan metode waterfall untuk membuat arsitektur microservice, Node.js sebagai pembuat server, REST API sebagai standar pertukaran data dan penghubung antar services, Docker sebagai container dan Mongodb sebagai database NoSQL.
Pembangunan Pusat Pengendalian Operasional Keamanan Informasi (Pusdalops Kami) guna Meningkatkan Pelayanan E-Gov dari Ancaman Kejahatan Siber
Authors: Yuswanto Andrie , Wibowo Budi 
Published: March 2021

Isu strategis pengelolaan keamanan informasi pada layanan e-Government di Pemprov DKI Jakarta saat ini merupakan hal terpenting seiring dengan kejahatan siber/cyber crime yang semakin meningkat, oleh karena itu diperlukan Sistem Informasi Jaringan dan Keamanan Informasi (SIJAKI). Tujuan dari inovasi ini adalah membangun web layanan informasi melalui SIJAKI, IT Security Operation Centre (SOC) atau Pusat Pengendalian Operasi Keamanan Informasi (PUSDALOPS KAMI) dan Live Chat/open ticket untuk media konsultasi terkait keamanan informasi. Untuk mewujudkan tujuan inovasi dilakukan beberapa tahapan jangka pendek antara lain: pembentukan tim efektif, pengumpulan data, pembuatan sistem, uji coba sistem, implementasi, pelatihan dan monitoring evaluasi pada proyek perubahan yang sudah di lakukan. SIJAKI yang telah dilaksanakan dan diimplemetasikan berhasil menekan jumlah peretasan website layanan e-Government milik Pemprov DKI Jakarta dan kejahatan siber lainnya sehingga layanan e-Government yang diberikan menjadi aman, lancar dan terjaga kerahasiannya
IGNORANCE AND INQUIRY
Authors: Pritchard Duncan 
Published: March 2021

Abstract
It is argued that the two main accounts of ignorance in the contemporary literature—in the terms of the lack of knowledge and the lack of true belief—are lacking in key respects. A new way of thinking about ignorance is offered that can accommodate the motivations for both of the standard views, but which in the process also avoids the problems that afflict these proposals. In short, this new account of ignorance incorporates the idea that ignorance essentially involves not just the absence of a certain epistemic good, but also an intellectual failing of inquiry. It is further contended that making sense of this normative dimension to ignorance requires one to situate one’s account of ignorance within a wider epistemic axiology.
Age-related features of cancer incidence in Omsk and Orenburg Regions
Authors: Shirlina N. G. , Kolchin A. S. , Stasenko V. L. , Klimushkin A. V. , Vyaltsin S. V. 
Published: March 2021

Aim. To assess the age-related cancer incidence in Omsk and Orenburg Regions.Materials and Methods. We analysed the statistical reports (form 7) obtained from the health authorities of Omsk and Orenburg Regions from 2010 to 2019.Results. Age-specific indicators of cancer incidence in the indicated regions differed significantly (р < 0.001). In the Omsk Region, cancer incidence showed a 65-fold increase with age (from 20 to 79 years), reaching the maximum values at the age of 75-79 years and then decreasing in subjects > 80 years of age (p < 0.05). In the Orenburg region, age-related incidence rates increased 95-fold from 20 to 79 years, reaching a maximum level in the age group of 70-79 years, that was also followed by a decrease in the population over 80 years of age (p < 0.05). Trends in cancer incidence in Omsk and Orenburg Regions were similar to those in Russia, yet the rate was 1.4-1.8-fold lower. Cancer incidence in both regions had a moderate upward trend (increment of 1.2% and 1.5%, respectively; p < 0.001). The highest increase in cancer incidence was detected in subjects between 30 and 39 years and over 80 years of age (Omsk and Orenburg Regions, increment of 1.4% and 2.5%; 1.3% and 1.3%, respectively; p < 0.001).Conclusions. Cancer incidence in the Orenburg Region significantly exceeds that in the Omsk region, yet both of the regions are characterised by the specific trends. We found the most significant increase in cancer incidence in subjects > 80 years of age over the last decade, which was more pronounced in the Omsk Region in comparison with the Orenburg Region.
Epidemic process of respiratory infections and particulate matter as a route for transmission of multidrug-resistant microorganisms in medical organisations
Authors: Chezganova E. A. , Medvedeva N. V. , Sakharova V. M. , Brusina E. B. 
Published: March 2021

Aim. To study the trends in the prevalence of respiratory tract infections in the population of Kemerovo Region and to interrogate the particulate matter as a possible route for the transmission of multidrug-resistant microorganisms into medical organisations.Materials and Methods. We investigated the prevalence of acute respiratory infections and community-acquired pneumonia among the population of Kuzbass (Kemerovo Region) according to the offcial medical records collected from 2004 to 2020. The study included 10,320,384 cases of acute respiratory infections, 145,357 cases of community-acquired pneumonia, 344,703 hospitalisations of the adults (subjects ≥ 18 years of age) and 75,041 hospitalisations of children (< 18 years of age). Collection of particulate matter samples (n = 97) was performed using sterile gloves and containers from ventilation grilles and adjacent air ducts of the exhaust ventilation systems in various healthcare settings. Bacterial composition of the dust was examined using a VITEK 2 Compact biochemical analyzer. Viral diversity was screened by polymerase chain reaction.Results. Over the study period, respiratory infections were common in Kemerovo Region (average prevalence 22,155.9 per 100,000 population) and showed an increasing incidence. Frequency of respiratory infections among the hospitalised patients was 207.14 per 1,000, being 1.63-fold higher in children than in adults (304.15 and 186.02, respectively). In 2020, the proportion of cefotaxime-resistant Klebsiella spp. was 26.20% that was strikingly high compared to 2019. Hospital particulate matter frequently (71.13% samples) harboured multidrug-resistant microorganisms.Conclusions. High prevalence and morbidity from respiratory infections in Kemerovo Region are combined with high prevalence and biodiversity of airborne microorganisms, in particular multidrug-resistant microbes contaminating the hospital particulate matter.
Positioning the Portrayal of White Protagonists in O.A Bushnell’s the Return of Lono and Ka’a’awa
Authors: Indriyanto Kristiawan , Adi Ida Rochani , Rokhman Muh. Arif 
Published: March 2021

This paper explores the role of literature in the post-truth age through reading on O.A Bushnell’s the Return of Lono and Ka’a’awa. A Hawai’ian novelist, Bushnell contextualizes the earliest interactions between the native Hawai’ian (Kanaka Maoli) and the white settlers which began with the arrival of Captain Cook’s expedition in 1778. Through his fictions, Bushnell underlines positive portrayal of the white characters to provide a counter-discourse to the generally accepted history of Hawai’ian colonialism. Through first person point of view, white characters become the central figure in both of Bushnell’s fictions. Through reading on O.A Bushnell’s narration, this paper aims to elaborate how the Hawai’ian natives also become a willing partner in western colonialism which highlights their colonial complicity. The concept of colonial complicity is employed to highlight the participation of the natives in promoting Western way of thinking. The analysis argues that although Bushnell contextualizes the complicity of the Hawai’ians in promoting Western discourse, resistance also occurs through creation of a hybrid culture. This paper concludes that in the post truth era, literature should always strive to uncover the truth based on subjective interpretation instead of abiding of a universal truth.
The Study of Reduplication and Retriplication in the Yoruba Language
Authors: Friday-Otun Joseph Omoniyi 
Published: March 2021

The Yoruba language, a regional lingua franca in Nigeria, which belongs to the Kwa sub-family of Kordofanian phylum of the larger African language family, is spoken in Nigeria, Togo, Ghana, Liberia, Brazil, Cuba, etc. The language attests a very productive feature of reduplication which has attracted the attention of many scholars. But its extended form, tagged, “retriplication” in this paper, remains largely unexplored. This study examines the form and functions of reduplication and retriplication which are two morphological processes where the former serves as a pedestal to the latter. While applying the participant observation method to elicit data from main Yoruba cities in Nigeria, the Pulleyblank (2009) model, as well as the descriptive and context usage approaches are employed to analyse and discuss the data. The study reveals that while reduplication process actualises intensification, nominalisation, emphasis and comparative qualifying, retriplication serves for more intensification, wider nominalisation, more emphasis and superlative qualifying. The research further reveals that, while all cases of verb and adjective reduplicates can be retriplicated without generating unacceptable utterances in Yoruba, the gerundive reduplicates cannot culminate in retriplication. However, kinship reduplicate allows retriplication when stretched to the third generation. The paper concludes by calling for more study on retriplication in other languages of the world, particularly, African and Asian languages that massively exhibit the two phenomena.
Loyalitas Konsumen dalam Penggunaan Jasa Rumah Duka (Studi Kasus pada Rumah Duka Jelambar)
Authors: Santoso Hellen Gabrellia , Loisa Riris 
Published: March 2021

This study discusses consumer loyalty in the use of funeral home services. The theory used in this research is the theory of consumer loyalty, word of mouth theory, promotion theory, and service theory. This research uses a case study method with a qualitative descriptive research approach. The data in this study were obtained from 1 staff member and 5 (five) users of funeral home services. Funeral home services are usually used by Chinese Buddhists, Confucians, Christians and Catholics. Funeral homes don't really do marketing promotions, such as price discounts, advertisements, social media activations, and so on. Initially people know and can use the funeral home services through word of mouth. In addition, the area where they live is also close to the location of the funeral home. After using a funeral home service, they are satisfied with the service provided, so they will use the same funeral home service if needed. Because of the use of more than 1 (one) time, consumers can be said to be loyal or loyal. Consumer loyalty can be seen from their willingness to give recommendations (word of mouth) of funeral homes that they use to others. The conclusion of this study, one form of consumer loyalty is in the form of word of mouth. The location and services provided are some of the considerations underlying the funeral home consumer loyalty in this study. Penelitian ini membahas mengenai loyalitas konsumen dalam penggunaan jasa rumah duka. Teori yang digunakan dalam penelitian ini adalah teori loyalitas konsumen, teori word of mouth, teori promosi, dan teori service atau pelayanan. Penelitian ini menggunakan metode studi kasus dengan pendekatan penelitian deskriptif kualitatif. Data dalam penelitian ini diperoleh dari 1 satu orang staf dan 5 (lima) orang pengguna jasa rumah duka. Jasa rumah duka biasanya digunakan oleh masyarakat Tionghoa beragama Buddha, Konghucu, Kristen, dan Katolik. Rumah duka tidak terlalu melakukan promosi pemasaran, seperti potongan harga, memasang iklan, pengaktifan sosial media, dan lainnya. Awalnya orang mengetahui dan dapat menggunakan jasa rumah duka melalui word of mouth. Selain itu, daerah tempat tinggal mereka juga dekat dengan lokasi rumah duka. Setelah menggunakan jasa rumah duka, mereka merasa puas akan service atau pelayanan yang diberikan sehingga mereka akan menggunakan jasa rumah duka yang sama apabila membutuhkan. Karena penggunaan lebih dari 1 (satu) kali, konsumen dapat dikatakan setia atau loyal. Loyalitas konsumen dapat dilihat dari kesediaan mereka akan memberikan rekomendasi (word of mouth) rumah duka yang mereka gunakan kepada orang lain. Kesimpulan dari penelitian ini, salah satu bentuk loyalitas konsumen adalah dalam bentuk word of mouth. Lokasi dan pelayanan yang diberikan merupakan beberapa pertimbangan yang melatarbelakangi loyalitas konsumen rumah duka pada penelitian ini.