bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical, pathological and genetic characteristics of Perry disease—new cases and literature review
Authors: Dulski Jarosław , Cerquera‐Cleves Catalina , Milanowski Lukasz , Kidd Alexa , Sitek Emilia J. , Strongosky Audrey , Vanegas Monroy Ana María , Dickson Dennis W. , Ross Owen A. , Pentela‐Nowicka Jolanta , Sławek Jarosław , Wszolek Zbigniew K. 
Published: August 2021

AbstractBackground and purposePerry disease (or Perry syndrome) is an autosomal dominant neurodegenerative disorder characterized by parkinsonism, neuropsychiatric symptoms, central hypoventilation, weight loss and distinct TDP‐43 pathology. It is caused by mutations of the DCTN1 gene encoding an essential component of axonal transport. The objectives were to provide the current state of knowledge on clinical, pathological and genetic aspects of Perry disease, as well as practical suggestions for the management of the disease.MethodsData on new patients from New Zealand, Poland and Colombia were collected, including autopsy report. Also all of the published papers since the original work by Perry in 1975 were gathered and analyzed.ResultsParkinsonism was symmetrical, progressed rapidly and was poorly responsive to L‐Dopa; nonetheless, a trial with high doses of L‐Dopa is warranted. Depression was severe, associated with suicidal ideations, and benefited from antidepressants and L‐Dopa. Respiratory symptoms were the leading cause of death, and artificial ventilation or a diaphragm pacemaker prolonged survival. Weight loss occurred in most patients and was of multifactorial etiology. Autonomic dysfunction was frequent but underdiagnosed. There was a clinical overlap with other neurodegenerative disorders. An autopsy showed distinctive pallidonigral degeneration with TDP‐43 pathology. Genetic testing provided evidence of a common founder for two families. There was striking phenotypic variability in DCTN1‐related disorders. It is hypothesized that oligogenic or polygenic inheritance is at play.ConclusionsPerry disease and other DCTN1‐related diseases are increasingly diagnosed worldwide. Relatively effective symptomatic treatments are available. Further studies are needed to pave the way toward curative/gene therapy.
Accelerated extractions of North Atlantic cod and herring, 1520–1790
Authors: Holm Poul , Nicholls John , Hayes Patrick W. , Ivinson Josh , Allaire Bernard 
Published: August 2021

AbstractWe propose the concept of Accelerated Marine Extraction to signify two periods when rapidly increasing cod (Gadus morhua, Gadidae) and herring (Clupea harengus, Clupeidae) fisheries, c.1540–1600 and c. 1730–1790, exceeded human demographic growth. Total landings vastly exceeded previous assessments and more than doubled between 1520 and 1620 from about 220,000 metric tonnes (t) to 460,000 t. Supplies of cod and herring to the European market peaked in 1788 at more than 1 million t before the unrest connected with the French Revolution brought many fisheries to a temporary halt. Accelerated Marine Extractions increased European food security at times of human demographic growth by almost doubling the supplies of fish protein per capita. While herring was the most important species by 1520, cod dominated through the period 1540–1790, and the trajectories of cod and herring extractions differed significantly. Cod landings increased almost ten‐fold between 1520 and 1790, driven by strong and sustained landings in the Northwest Atlantic. Herring landings remained stable through the 16th century but declined severely through the next 150 years. However, from 1750, herring landings quadrupled, largely because of Swedish west coast fisheries. The results fundamentally shift our understanding of the scale of Atlantic fisheries in the past and underline the role of marine resources for European societies.
Academic Womxn and Their Partners: Managing Scholarly Expectations During the Coronavirus Pandemic With the Support of Intimate Relationships in Quarantine
Authors: Brown Kristina S. , Bender Sara , Vega Olga , Hensley Kasitz Deanna L. 
Published: August 2021

ObjectiveThe purpose of this study was to explore how academic womxn experience their partnerships during quarantine and to determine the impact of those relational dynamics on scholarly productivity.BackgroundPast literature indicates traumatic events and extended quarantine is associated with negative mental health outcomes. While primary partnerships serve as one protective factor, extended quarantine with one's partner introduces novel stress to a relationship, which may have unintended outcomes, including those that affect productivity.MethodAn online survey was provided to academic womxn invested in scholarship. Responses from participants who identified as in a relationship (n = 67) were coded using thematic analysis through a feminist lens.FindingsParticipants highlighted three major themes across their responses: time and space, communication, and needs. These findings reflected stressors typical within couple relationships but highlighted important considerations for partners of academic womxn in support of their scholarly activity during quarantine.ConclusionThough the flexibility available during the pandemic for academic womxn provided time and space for some to nurture their relationship as well as focus on scholar activity, this was not consistent across partners.ImplicationsFindings show the mixed experiences of partners and confirm the importance of communication, especially about time and space and professional needs. Recommendations can be extrapolated to other processional and career partnerships.
Do changes in MD&A section tone predict investment behavior?
Authors: Berns John , Bick Patty , Flugum Ryan , Houston Reza 
Published: August 2021

AbstractWe find that changes in managerial tone predict firm corporate investment activities. Tone changes within the Management Discussion and Analysis section of the 10‐K are positively related to subsequent capital investments and M&A activity. We find the predictive content of tone changes to be present at the firm and industry‐levels, and when accounting for alternative sources of incremental information associated with firm investment activities. Our findings broaden the scope of information encapsulated by changes in financial statement tone.
Inpatient knee pain after hip fracture surgery affects gait speed in older adults: A retrospective chart‐referenced study
Authors: Kaizu Yoichi , Miyata Kazuhiro , Arii Hironori , Yamaji Takehiko 
Published: August 2021

AimPost‐hip fracture knee pain (PHFKP) develops in 28–37.4% of patients with hip fracture and contributes to prolonged hospitalization. Although reduced balance and gait speed contribute to falls, the effects of PHFKP remain unclear. This study aimed to clarify whether PHFKP is a factor in balance and gait speed.MethodsWe retrospectively reviewed the medical records of patients after hip fracture. Development of PHFKP, basic information, and physical function were examined. Berg balance scale (BBS) and maximum walking speed (MWS) were collected at discharge. These parameters were compared with the presence or absence of PHFKP. In addition, multiple analyses were conducted with BBS and MWS as dependent variables and PHFKP as one of the independent variables.ResultsOf the 146 patients enrolled, 43 (29.5%) developed PHFKP, and 37.2% of patients with PHFKP showed residual symptoms at discharge. Intensity of PHFKP was mostly mild to moderate. The PHFKP group showed an extended length of stay (+13.3 days) and a tendency toward more discharges to facilities compared with the control group. Knee extension range of motion limitation, knee extensor strength, and BBS did not differ between groups, while MWS was significantly lower in the PHFKP group (0.85 ± 0.32 m/s vs. 1.07 ± 0.39 m/s). Multiple analyses showed that development of PHFKP was not associated with BBS, but was associated with decreased MWS (standardized beta = −0.202, P = 0.005).ConclusionsPHFKP was identified as an independent factor in gait speed decline. PHFKP patients should be monitored for reduced gait speed during rehabilitation. Geriatr Gerontol Int 2021; 21: 830–835.
Anxiety, depression and social support across pregnancy in women with a history of recurrent miscarriage: A prospective study
Authors: Qu Jia , Weng Xue‐ling , Gao Ling‐ling 
Published: August 2021

AbstractAimWomen with a history of recurrent miscarriage are a vulnerable population. This study aimed to examine changes and relationships among anxiety, depression and social support across three trimesters of pregnancy in women with a history of recurrent miscarriage.MethodsA prospective, longitudinal study was employed. A convenience sample of 166 pregnant women with a history of recurrent miscarriage completed the measures at their 6–12, 20–24 and 32–36 gestational weeks.ResultsThe prevalence of anxiety at early, middle and late pregnancy was 47.6%, 36.1% and 32.5%, respectively, whereas that of depression was 38%, 34.3% and 31.3%, respectively. Social support scores increased from early pregnancy to middle pregnancy then remained in late pregnancy. There were correlations among anxiety, depression and social support across pregnancy.ConclusionsAnxiety and depression were highly prevalent in pregnant women with a history of recurrent miscarriage, especially in early pregnancy when the level of social support was the lowest. Social support is an essential buffer against anxiety and depression throughout the pregnancy.
‘First tonight, the contentious new code telling nurses to say, ‘sorry for being white’: Mental health nurses’ beliefs about their Code of Conduct and cultural safety for Aboriginal and Torres Strait Islander Peoples
Authors: Molloy Luke , Beckett Paul , Chidarikire Sherphard , Scott Matthew P. , Guha Monica D. , Tran Merrick Tammy , Patton Declan 
Published: August 2021

AbstractThe Nursing and Midwifery Board of Australia’s Code of Conduct for Nurses sets out the professional behaviour and conduct expectations for nurses in all practice settings. The publication of a revised version in 2018, which included expectations related to culturally safe and respectful practice and Aboriginal and Torres Strait Islander Peoples’ health, caused reverberations beyond the profession of nursing. A controversy that the changes required nurses to verbally apologize for being white before their interactions with Aboriginal and Torres Strait Islander people gained the attention of the mainstream media. This interpretation, which came from outside nursing, was disputed by the Board. Challenged by these events, the authors were interested in understanding the actual impacts of the changes from the perspectives of nurses in practice. This research, carried out nearly three years after publication, has focused specifically on the speciality of mental health nurses in this context. The objective of this research was to undertake a social analysis focused on the impact that changes in the Code have had on the culture of mental health nursing utilizing a qualitative methodology. Eight mental health nurses were interviewed. The research found that there was little evidence of any impact on mental health nursing practice. Many of the participants were unaware of the amendments to the Code, whilst those nurses who were aware did not perceive that it had led to any real change within mental health nursing or service delivery.
When it rains, it pours: Multifactor asset management in good and bad times
Authors: Brière Marie , Szafarz Ariane 
Published: August 2021

AbstractWe examine the profitability of multifactor portfolios on the US stock market. Using passive sector investing as the benchmark, we assess the performances of factor‐based asset management strategies in good and bad times. When short selling is unrestricted, factor investing outperforms sector investing in all respects. For long‐only portfolios, our results reveal a trade‐off between the risk premia associated with factors and the diversification potential of sectors. Multifactor investing tends to be more profitable than the benchmark during good times but less attractive during bad times, when diversification is needed the most.
Cost‐effectiveness of secondary fracture prevention intervention for Medicare beneficiaries
Authors: Nayak Smita , Singer Andrea , Greenspan Susan L. 
Published: August 2021

AbstractBackgroundSecondary fracture prevention intervention such as fracture liaison services are effective for increasing osteoporosis treatment rates, but are not currently widely used in the United States. We evaluated the cost‐effectiveness of secondary fracture prevention intervention after osteoporotic fracture for Medicare beneficiaries.MethodsAn individual‐level state‐transition microsimulation model was developed to evaluate the cost‐effectiveness of secondary fracture prevention intervention compared with usual care for U.S. Medicare patients aged 65 and older who experience a new osteoporotic fracture. Patients who initiated pharmacotherapy and remained adherent were assumed to be treated for 5 years. Outcome measures included subsequent fractures, average lifetime costs, quality‐adjusted life‐years (QALYs), and incremental cost‐effectiveness ratios in 2020 U.S. dollars per QALY gained. The model time horizon was lifetime, and analysis perspective was payer.ResultsBase‐case analysis results showed that the secondary fracture prevention intervention strategy was both more effective and less expensive than usual care—thus, it was cost‐saving. Model findings indicated that the intervention would reduce the number of expected fractures by approximately 5% over a 5‐year period, preventing approximately 30,000 fractures for 1 million patients. Secondary fracture prevention intervention resulted in an average cost savings of $418 and an increase in QALYs of 0.0299 per patient over the lifetime; for 1 million patients who receive the intervention instead of usual care, expected cost savings for Medicare would be $418 million dollars. One‐way and probabilistic sensitivity analyses supported base‐case findings of cost savings.ConclusionSecondary fracture prevention intervention for Medicare beneficiaries after a new osteoporotic fracture is very likely to both improve health outcomes and reduce healthcare costs compared with usual care. Expansion of its use for this population is strongly recommended.
High‐resolution MRI of the human palatine tonsil and its schematic anatomic 3D reconstruction
Authors: Herrmann Karl‐Heinz , Hoffmann Franziska , Ernst Günther , Pertzborn David , Pelzel Daniela , Geißler Katharina , Guntinas‐Lichius Orlando , Reichenbach Jürgen R. , von Eggeling Ferdinand 
Published: August 2021

AbstractThe palatine tonsils form an important part of the human immune system. Together with the other lymphoid tonsils of Waldeyer's tonsillar ring, they act as the first line of defense against ingested or inhaled pathogens. Although histologically stained sections of the palatine tonsil are widely available, they represent the tissue only in two dimensions and do not provide reference to three‐dimensional space. Such a representation of a tonsillar specimen based on imaging data as a 3D anatomical reconstruction is lacking both in scientific publications and especially in textbooks. As a first step in this direction, the objective of the present work was to image a resected tonsil specimen with high spatial resolution in a 9.4 T small‐bore pre‐clinical MRI and to combine these data with data from the completely sectioned and H&E stained same palatine tonsil. Based on the information from both image modalities, a 3D anatomical sketch was drawn by a scientific graphic artist. In perspective, such studies could help to overcome the difficulty of capturing the spatial extent and arrangement of anatomical structures from 2D images and to establish a link between three‐dimensional anatomical preparations and two‐dimensional sections or illustrations, as they have been found so far in common textbooks and anatomical atlases.
Chemotherapy for ovarian cancer during pregnancy: A systematic review and meta‐analysis of case reports and series
Authors: Jiang Xingzhi , Ye Zhongxue , Yu Wen , Fang Qian , Jiang Yafen 
Published: August 2021

AbstractAimThis study aims to investigate the safety and efficacy of chemotherapy in ovarian cancer patients in pregnancy.MethodsIn this study, eligible studies were searched on PubMed, Embase, and Cochrane Library databases up to December 31, 2020. Data were calculated and presented by frequency and percentage, mean ± standard deviation (SD), and median (range), respectively. Kaplan–Meier survival analysis was performed to estimate overall survival (OS) and progression‐free survival (PFS).ResultsFinally, 34 studies including 40 ovarian cancer cases receiving chemotherapy during pregnancy were included. All 40 patients received chemotherapy during pregnancy. During the follow‐up, seven of 37 (18.9%) women had a relapse and four of them (4/7, 57.1%) died of recurrence. Survival analysis failed to reach median OS and PFS within the follow‐up (range 3–72 months). Better OS and PFS after chemotherapy in pregnancy were obtained in women with early‐stage ovarian cancer (I) compared with those with advanced stage (III–IV). Neither OS nor FS differed between women treated with multi‐drugs and those with monotherapy. Forty‐one newborns were delivered from 40 pregnant women. Thirty‐four (34/41, 82.9%) were completely healthy at birth and the end of follow‐up (range 0.18–160 months). However, one newborn died 5 days after birth due to multiple congenital malformations, and another one developed Tourette's syndrome, aphasia, Asperger's syndrome as well as speech delay.ConclusionsThis meta‐analysis first reveals the efficacy and safety of chemotherapy for ovarian cancer during pregnancy, especially for early‐stage patients. Cisplatin or carboplatin is suggested to be used as monotherapy to reduce adverse effects.
Association of the metabolic syndrome with mortality and major adverse cardiac events: A large chronic kidney disease cohort
Authors: Pammer Lorenz M. , Lamina Claudia , Schultheiss Ulla T. , Kotsis Fruzsina , Kollerits Barbara , Stockmann Helena , Lipovsek Jan , Meiselbach Heike , Busch Martin , Eckardt Kai‐Uwe , Kronenberg Florian ,   for the GCKD Investigators
Published: August 2021

AbstractBackgroundMetabolic syndrome with its key components insulin resistance, central obesity, dyslipidaemia, and hypertension is associated with a high risk for cardiovascular events and all‐cause mortality in the general population. However, evidence that these findings apply to patients with chronic kidney disease (CKD) with moderately reduced estimated glomerular filtration rate and/or albuminuria is limited.ObjectivesWe aimed to investigate the association between metabolic syndrome and its components with all‐cause mortality and cardiovascular outcomes in CKD patients.MethodsProspective observation of a cohort of 5110 CKD patients from the German Chronic Kidney Disease study with 3284 (64.3%) of them having a metabolic syndrome at baseline.ResultsDuring the follow‐up of 6.5 years, 605 patients died and 650 patients experienced major cardiovascular events. After extended data adjustment, patients with a metabolic syndrome had a higher risk for all‐cause mortality (hazard ratio [HR] = 1.26, 95% confidence interval [CI]: 1.04–1.54) and cardiovascular events (HR = 1.48, 95% CI: 1.22–1.79). The risk increased steadily with a growing number of metabolic syndrome components (increased waist circumference, glucose, triglycerides, hypertension and decreased HDL cholesterol): HR per component = 1.09 (95% CI: 1.02–1.17) for all‐cause mortality and 1.23 (95% CI: 1.15–1.32) for cardiovascular events. This resulted in hazard ratios between 1.50 and 2.50 in the case when four or five components are present. An analysis of individual components of metabolic syndrome showed that the glucose component led to the highest increase in risk for all‐cause mortality (HR = 1.68, 95% CI: 1.38–2.03) and cardiovascular events (HR = 1.81, 95% CI: 1.51–2.18), followed by the HDL cholesterol and triglyceride components.ConclusionsWe observed a high prevalence of metabolic syndrome among patients with moderate CKD. Metabolic syndrome increases the risk for all‐cause mortality and cardiovascular events. The glucose and lipid components seem to be the main drivers for the association with outcomes.
Supplemental impact of cassava (Manihot esculenta Crantz) hard pellet and residue pellet‐based diet as a replacement for corn on the growth performance, total tract digestibility and blood profiles in pigs
Authors: Sureshkumar Shanmugam , Balamuralikrishnan Balasubramanian , Kim In Ho 
Published: August 2021

AbstractThe present study was conducted to evaluate the effect of cassava hard pellet and residue pellet‐based diet as a replacement for corn on the growth performance, total tract digestibility and blood profile in pigs. Three experiments were conducted to evaluate the processed cassava as replacement for corn in pigs. In Exp. 1, seventy‐two weanling pigs with an average initial body weight of 6.44 ± 0.52 kg were assigned to one of the two treatments: CON, basal diet, and CHP, basal diet with cassava hard pellet for 28 days trial. The dietary inclusion of CHP had significantly decreased average daily gain of weanling pigs during d 1–14 and the overall experimental period. In addition, significant reduction was observed on gain‐to‐feed ratio during d 1–14, while no effect was noted on average daily feed intake. Exp. 2 was carried out for 42 days, in which 84 growing pigs were randomly assigned to 1 of 3 treatments with 4 pigs/pen and 7 pen/treatment. The three dietary treatments were supplement with 0%, 20% and 40% of cassava. Dietary inclusion of cassava supplementation has failed to affect the growth performance and blood profile during overall experiment. In Exp. 3, a total of 96 crossbred finishing pigs were randomly assigned to one of four dietary treatments containing 25% cassava in a 2 × 2 factorial design with two different levels of energy with or without 0.1% carbohydrase for 28 days. Pigs fed 0.1% carbohydrase with high energy diet reduced average daily feed intake and increased gain‐to‐feed ratio compared to those fed low energy diet. However, significantly enhanced nutrient digestibility in both energy and carbohydrase groups were observed. In summary, the inclusion of cassava basal diet with 0.1% carbohydrase supplementation has beneficially enhanced the growth performance and nutrient digestibility of pigs.
A critical exploration of nurses' perceptions of access to oncology care among Indigenous peoples: Results of a national survey
Authors: Horrill Tara C. , Martin Donna E. , Lavoie Josée G. , Schultz Annette S. H. 
Published: August 2021

AbstractInequities in access to oncology care among Indigenous peoples in Canada are well documented. Access to oncology care is mediated by a range of factors; however, emerging evidence suggests that healthcare providers, including nurses, play a significant role in shaping healthcare access. The purpose of this study was to critically examine access to oncology care among Indigenous peoples in Canada from the perspective of oncology nurses. Guided by postcolonial theoretical perspectives, interpretive descriptive and critical discourse analysis methodologies informed study design and data analysis. Oncology nurses were recruited from across Canada to complete an online survey (n = 78). Nurses identified a range of barriers experienced by Indigenous peoples when accessing oncology care, yet located these barriers primarily at the individual and systems levels. Nurses perceived themselves as mediators of access to oncology care; however, their efforts to facilitate access to care were constrained by the dominance of biomedicine within healthcare. Nurses' constructions of access to oncology care highlight the embedded narrative of individualism within nursing practice and the relative invisibility of racism as a determinant of equitable access to care among Indigenous peoples. This suggests a need for oncology nurses to better understand and incorporate structural determinants of health perspectives.