bluuebunny/crossref_metadata_2025_split huggingface dataset:
Track Dependence of Tropical Cyclone Intensity Forecast Errors in the COAMPS-TC Model
Authors: Kieu Chanh , Evans Cole , Jin Yi , Doyle James D. , Jin Hao , Moskaitis Jonathan 
Published: January 2021

AbstractThis study examines the dependence of tropical cyclone (TC) intensity forecast errors on track forecast errors in the Coupled Ocean–Atmosphere Mesoscale Prediction System for Tropical Cyclones (COAMPS-TC) model. Using real-time forecasts and retrospective experiments during 2015–18, verification of TC intensity errors conditioned on different 5-day track error thresholds shows that reducing the 5-day track errors by 50%–70% can help reduce the absolute intensity errors by 18%–20% in the 2018 version of the COAMPS-TC model. Such impacts of track errors on the TC intensity errors are most persistent at 4–5-day lead times in all three major ocean basins, indicating a significant control of global models on the forecast skill of the COAMPS-TC model. It is of interest to find, however, that lowering the 5-day track errors below 80 n mi (1 n mi = 1.852 km) does not reduce TC absolute intensity errors further. Instead, the 4–5-day intensity errors appear to be saturated at around 10–12 kt (1 kt ≈ 0.51 m s−1) for cases with small track errors, thus suggesting the existence of some inherent intensity errors in regional models. Additional idealized simulations under a perfect model scenario reveal that the COAMPS-TC model possesses an intrinsic intensity variation at the TC mature stage in the range of 4–5 kt, regardless of the large-scale environment. Such intrinsic intensity variability in the COAMPS-TC model highlights the importance of potential chaotic TC dynamics, rather than model deficiencies, in determining TC intensity errors at 4–5-day lead times. These results suggest a fundamental limit in the improvement of TC intensity forecasts by numerical models that one should consider in future model development and evaluation.
A cascade of exclusion: administrative burdens and access to citizenship in the case of Argentina’s National Identity Document
Authors: Chudnovsky Mariana , Peeters Rik 
Published: January 2021

Administrative burdens can hinder people’s social, political and economic participation. However, most empirical studies usually tackle the issue of how they affect access to citizenship merely indirectly. This article examines administrative exclusion from Argentina’s National Identity Document and its effects on a key social policy: the Universal Child Allowance. Findings indicate that: (1) administrative exclusion from official identity documents ‘feeds back’ into the construction of a vulnerable target group that is systematically excluded from social benefits and public services; and (2) limitations in the administrative capacity for identity registration and documentation ‘trickle down’ to complications in the implementation of social policies as target groups remain ‘off the radar’. Findings also demonstrate the importance of understanding administrative burdens as a systemic issue. Burdens manifest themselves at the level of citizen–state interactions but their causes and consequences are tied up with intractable institutional characteristics, administrative capacities and social inequalities. Points for practitioners Efforts by developing countries to develop effective social protection systems are often thwarted by limitations in the state’s capacity to identify and reach marginalized citizens. This suggests the need for a systemic perspective of the state’s entire capacity instead of merely focusing on the design of social protection programmes. Specifically, we demonstrate that complete, accessible and up-to-date civil registries, identity documents and other forms of registration are a precondition for transforming formal rights into a tangible reality for citizens.
When to Substitute a Missing Upper Lateral With a Canine: A Simplified Approach
Authors: Datta Renu 
Published: January 2021

Introduction: The upper lateral incisor is the most commonly missing tooth in the anterior segment. It leads to esthetic and functional imbalance for the patients. The ideal solution is the one that is most conservative and which fulfills the functional and esthetic needs of the concerned individual. Canine substitution is evolving to be the treatment of choice in most of the cases, because of its various advantages. These are special cases that need more time and effort from the clinicians due to space discrepancy in the upper and lower arches, along with the presentation of individual malocclusion. Aims and Objectives: Malocclusion occurring due to missing laterals is more complex, needing more time and effort from the clinicians because of space discrepancy, esthetic compromise, and individual presentation of the malocclusion. An attempt has been made in this article to review, evaluate, and tabulate the important factors for the convenience of clinicians. Method: All articles related to canine substitution were searched in the electronic database PubMed, and the important factors influencing the decision were reviewed. After careful evaluation, the checklist was evolved. Result: The malocclusions in which canine substitution is the treatment of choice are indicated in the tabular form for the convenience of clinicians. Specific treatment-planning considerations and biomechanics that can lead to an efficient and long-lasting result are also discussed. Conclusion: The need of the hour is an evidence-based approach, along with a well-designed prospective randomized control trial to understand the importance of each factor influencing these cases. Until that time, giving the available information in a simplified way can be a quality approach to these cases.
Eastern Europe and the geography of knowledge production: The case of the invisible gardener
Authors: Jehlička Petr 
Published: January 2021

The article contributes to the debates in geography on the inequality of knowledge production and the context-dependent hierarchy of knowledge claims. It seeks to make sense of the invisibility, to Western academia, of East European informal food provisioning as a research topic with the potential to inform debates and theorisations regarding alternative food systems. Looking at how East European informal food practices have been read from the West is instructive for understanding how certain knowledge ‘travels’ and becomes universally accepted knowledge – or theory – or remains a partial knowledge with validity restricted to specific places and circulating within specific subfields.
Effects of 12 Weeks of Progressive Early Active Exercise Therapy After Surgical Rotator Cuff Repair: 12 Weeks and 1-Year Results From the CUT-N-MOVE Randomized Controlled Trial
Authors: Kjær Birgitte Hougs , Magnusson S. Peter , Henriksen Marius , Warming Susan , Boyle Eleanor , Krogsgaard Michael Rindom , Al-Hamdani Ali , Juul-Kristensen Birgit 
Published: January 2021

Background: Traumatic full-thickness rotator cuff tears are typically managed surgically, followed by rehabilitation, but the load progression to reach an optimal clinical outcome during postoperative rehabilitation is unknown. Purpose: To evaluate whether there was a superior effect of 12 weeks of progressive active exercise therapy on shoulder function, pain, and quality of life compared with usual care. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: Patients with surgically repaired traumatic full-thickness rotator cuff tears were recruited from 2 orthopaedic departments and randomized to progressive active exercise therapy (PR) or limited passive exercise therapy (UC [usual care]). The primary outcome was the change in the Western Ontario Rotator Cuff Index (WORC) score between groups from before surgery to 12 weeks after surgery. Secondary outcomes included changes in the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire score, pain, range of motion, and strength. Adverse events were registered during the intervention period. Results: A total of 82 patients were randomized to the PR (n = 41) or UC (n = 41) group. All 82 patients (100%) participated in the 12-week assessment and 79 in the 1-year follow-up. At 12 weeks, there was no significant difference between the groups in the change in the WORC score from baseline adjusted for age, sex, and center (physical symptoms: P = .834; sports and recreation: P = .723; work: P = .541; lifestyle: P = .508; emotions: P = .568). Additionally, there was no between-group difference for the secondary outcomes including the WORC score at 1 year and the DASH score, pain, range of motion, and strength at 12 weeks and 1 year. Both groups showed significant improvements over time in all outcomes. In total, there were 13 retears (16%) at 1-year follow-up: 6 in the PR group and 7 in the UC group. Conclusion: PR did not result in superior patient-reported and objective outcomes compared with UC at either short- or long-term follow-up (12 weeks and 1 year). Registration: NCT02969135 ( ClinicalTrials.gov identifier)
Extracellular vesicles from three dimensional culture of human placental mesenchymal stem cells ameliorated renal ischemia/reperfusion injury
Authors: Zhang Xuefeng , Wang Nan , Huang Yuhua , Li Yan , Li Gang , Lin Yuxin , Atala Anthony J. , Hou Jianquan , Zhao Weixin 
Published: January 2021

Background: Three-dimensional (3D) culture has been reported to increase the therapeutic potential of mesenchymal stem cells (MSCs). The present study assessed the therapeutic efficacy of extracellular vesicles (EVs) from 3D cultures of human placental MSCs (hPMSCs) for acute kidney injury (AKI). Methods: The supernatants from monolayer culture (2D) and 3D culture of hPMSCs were ultra-centrifuged for EVs isolation. C57BL/6 male mice were submitted to 45 min bilateral ischemia of kidney, followed by renal intra-capsular administration of EVs within a 72 h reperfusion period. Histological, immunohistochemical, and ELISA analyses of kidney samples were performed to evaluate cell death and inflammation. Kidney function was evaluated by measuring serum creatinine and urea nitrogen. The miRNA expression profiles of EVs from 2D and 3D culture of hPMSCs were evaluated using miRNA microarray analysis. Results: The 3D culture of hPMSCs formed spheroids with different diameters depending on the cell density seeded. The hPMSCs produced significantly more EVs in 3D culture than in 2D culture. More importantly, injection of EVs from 3D culture of hPMSCs into mouse kidney with ischemia-reperfusion (I/R)-AKI was more beneficial in protecting from progression of I/R than those from 2D culture. The EVs from 3D culture of hPMSCs were more efficient against apoptosis and inflammation than those from 2D culture, which resulted in a reduction in tissue damage and amelioration of renal function. MicroRNA profiling analysis revealed that a set of microRNAs were significantly changed in EVs from 3D culture of hPMSCs, especially miR-93-5p. Conclusion: The EVs from 3D culture of hPMSCs have therapeutic potential for I/R-AKI.
Dementia and Early Do-Not-Resuscitate Orders Associated With Less Intensive of End-of-Life Care: A Retrospective Cohort Study
Authors: Luth Elizabeth A. , Pan Cynthia X. , Viola Martin , Prigerson Holly G. 
Published: January 2021

Background: Dementia is a leading cause of death among US older adults. Little is known about end-of-life care intensity and do-not-resuscitate orders (DNRs) among patients with dementia who die in hospital. Aim: Examine the relationship between dementia, DNR timing, and end-of-life care intensity. Design: Observational cohort study. Setting/Participants: Inpatient electronic health record extraction for 2,566 persons age 65 and older who died in 2 New York City hospitals in the United States from 2015 to 2017. Results: Multivariable logistic regression analyses modeled associations between dementia diagnosis, DNR timing, and 6 end-of-life care outcomes. 31% of subjects had a dementia diagnosis; 23% had a DNR on day of hospital admission. Patients with dementia were 18%-40% less likely to have received 4 of 6 types of intensive care (mechanical ventilation AOR: 0.82, 95%CI: 0.67 -1.00; intensive care unit admission AOR: 0.60, 95%CI: 0.49-0.83). Having a DNR on file was inversely associated with staying in the intensive care unit (AOR: 0.57, 95%CI: 0.47-0.70) and avoiding other intensive care measures. DNR placement later during the hospitalization and not having a DNR were associated with more intensive care compared to having a DNR upon admission. Conclusions: Having dementia and a do-not resuscitate order upon hospital admission are associated with less intensive end-of-life care. Additional research is needed to understand why persons with dementia receive less intensive care. In clinical practice, encouraging advance care planning prior to and at hospital admission may be particularly important for patients wishing to avoid intensive end-of-life care, including patients with dementia.
Outpatient fractionated ICE protocol in relapsed/refractory lymphomas: Efficacy and safety
Authors: Dada Reyad , Abdelghani Ehab Mosaad , Boubakra Tarek , Vayani Jaweed , Yousof Osama , Heaphy Emily L Goldman , Nawaz Azhar 
Published: January 2021

Methods In this retrospective trial, we analyzed data of patients with relapsed/refractory lymphoma who received outpatient fractionated ICE between 2011-2017 at a tertiary care center. The three weekly ICE protocol consisted of: ifosfamide 1500 mg/m2 infused over 2 h on days 1–3, carboplatin (5 AUC) on day 1, and etoposide 100 mg/m2 on days 1–3. Rituximab 375 mg/m2 was given to patients with CD20 positive B cell Non-Hodgkin lymphoma. Results Total of 89 patients were included in this research project. Majority of patients had Hodgkin lymphoma (64%). Mean number of ICE cycles received was 2.5. Complete remission and partial remission rates for primary refractory (62.9%) and non-primary refractory (36.4%) disease were 10.5% and 26.3% versus 41.9% and 29.0% respectively. Event free survival rate was 14.5 months (95% CI 7.7–28.0) and overall survival rate 88.7 months (95% CI 48.1–NR). Grade 3 hematological toxicities were documented in 19.1% of patients with 10.1% experiencing neutropenia and 9% thrombocytopenia. 5.6% had febrile neutropenia. Conclusions Our study included, to our knowledge, the largest number of patients treated with outpatient fractionated ICE. Results demonstrated that this regimen might be a reasonable replacement for classic ICE regimen in many patients with lymphoma. It has a favorable safety profile. However, patients with primary refractory lymphomas need more effective regimens.
Commentary: Should all cancer patients be tested for COVID-19 before each chemotherapy cycle?
Authors: Yekedüz Emre , Utkan Güngör , Ürün Yüksel 
Published: January 2021

Cancer patients under active chemotherapy are more vulnerable to coronavirus disease 19 (COVID-19). There are still some controversies regarding routine polymerase chain reaction testing of asymptomatic cancer patients before chemotherapy cycles. Despite a lack of data, Al-Shamsi et al. showed higher COVID-19 positivity rate among asymptomatic cancer patients. Furthermore, mortality rate was higher in this group of patients. There is no high evidence-based recommendation from the cancer societies for testing asymptomatic patients before each chemotherapy cycle. In this commentary, we assessed the current publications and guidelines regarding this issue.
Effect of applying inclusion and exclusion criteria of phase III clinical trials to multiple sclerosis patients in routine clinical care
Authors: Jalusic Kris Oliver , Ellenberger David , Rommer Paulus , Stahmann Alexander , Zettl Uwe , Berger Klaus 
Published: January 2021

Background: Newly approved, drug-modifying therapies are associated with still unknown adverse events, although clinical trials leading to approval have strict inclusion and exclusion criteria and analyse safety and efficacy. Objectives: The aim of this study was to analyse the eligibility of multiple sclerosis (MS) patients treated in routine care into the phase III clinical trial of the respective drug. Methods: In total, 3577 MS patients with 4312 therapies were analysed. Patients with primary-progressive MS were excluded. Inclusion and exclusion criteria of phase III clinical trials in relapsing–remitting MS were adopted and subsequently applied. A comparison in clinical and sociodemographic characteristics was made between patient who met the criteria and those who did not. Results: 83% of registered patients would not have been eligible to the respective phase III clinical trial. Relapse was the single most frequent criterion not fulfilled (74.7%), followed by medication history (21.2%). Conclusion: The majority of MS patients treated in routine care would not have met clinical trials criteria. Thus, the efficacy and safety of therapies in clinical trials can differ from those in the real world. Broader phase III inclusion criteria would increase their eligibility and contribute to a better generalizability of the results in clinical trials.
Nursing Procedures for the Prevention and Treatment of Mucositis Induced by Cancer Therapies: Clinical Practice Guideline Based on an Interdisciplinary Consensus Process and a Systematic Literature Search
Authors: Steinmann Diana , Babadağ Savaş Burcu , Felber Sabine , Joy Sosamma , Mertens Isabelle , Cramer Holger , Paul Anna , Layer Monika , Klafke Nadja , Stolz Regina , Heyder Ute , Neuberger Petra , Winkler Marcela , Idler Christel , Heine Rolf , Kaschdailewitsch Elke , John Heike , Schmeling Beeke , Zielke Tatjana , Horneber Markus , Witt Claudia M. , Voiss Petra 
Published: January 2021

Background: Patients with cancer receiving tumor therapy often suffer from oral mucositis. Objectives: The aim of this project was to summarize experiences with nursing procedures by experts in integrative oncology and to establish recommendations for nursing interventions that can prevent or cure mucositis. Methods: The study design was an interdisciplinary consensus process based on a systematic literature search. Results: The panel discussed and agreed on 19 nursing procedures, which included mouthwashes, such as teas, supplements, oil applications, and different kinds of ice cubes to suck, as well as flaxseed solution, propolis, and mare milk. Twelve interventions were classified as effective, with effectiveness for OraLife, propolis, sea buckthorn pulp oil, marshmallow root tea also for xerostomia, Helago chamomile oil, mare milk, and Saliva Natura rated as highly effective in clinical experience. In the systematic literature search, a total of 12 out of 329 randomized controlled trials and meta-analyses on chamomile (n = 3), Calendula (n = 1) and sage (n = 1), propolis (n = 2), and sucking ice cubes (cryotherapy; n = 5) met all inclusion criteria. Trial evidence for effectiveness in oral mucositis was revealed for propolis and cryotherapy. Conclusions: The current evidence supports the use of some nursing procedures (f.e. propolis for 2 and 3 grade mucositis) for improving oral mucositis during cancer therapies. There is still a need to define general clinical practice guidelines for the supportive treatment of mucositis, as well as for more interdisciplinary research in this area.
A Novel Subxiphoid Approach for Bilateral Internal Thoracic Artery Harvesting
Authors: Amirjamshidi Hossein , Sauer Jude S. , Barrus Bryan , Knight Peter A. , Prasad Sunil M. 
Published: January 2021

Objective Bilateral internal thoracic artery (BITA) bypass can enable more complete arterial revascularization procedures. Minimally invasive cardiac surgery (MICS) can offer significant patient benefits. New minimally invasive technology for sternal retraction and tissue manipulation is needed to enable ergonomic and reliable minimally invasive ITA harvesting. The goal of this research was to develop technology and techniques, along with experimental testing and training models, for a sternal-sparing approach to in situ BITA harvesting through a small subxiphoid access site. Methods This study focused on optimizing custom equipment and methods for subxiphoid BITA harvesting initially in a porcine model (19 pig carcasses, 36 ITAs) and subsequently in 7 cadavers (14 ITAs). Results Fifty consecutive ITAs were successfully harvested using this remote access approach. The last 20 ITA specimens harvested from the porcine model were explanted and measured; the average length of the free ITA grafts was 12.8 ± 0.9 cm (range 10.8 to 14.2 cm) with a mean time of 23.3 ± 5.2 minutes (range 13 to 25 minutes) for each harvest. Conclusions Early results demonstrate that both ITAs can be reliably harvested in a skeletonized fashion in situ through sternal-sparing, small subxiphoid access in 2 experimental models. This innovative approach warrants further exploration toward facilitating complete arterial revascularization and the further adoption of minimally invasive coronary artery bypass graft surgery.
Endovascular treatment of type 1 and type 4 non-saccular aneurysms of cerebral arteries – a single-Centre experience
Authors: Borota Ljubisa , Nyberg Christoffer , Lenell Samuel , Semnic Robert , Mahmoud Ehab 
Published: January 2021

Aim of the study The aim of this study was to evaluate our results regarding treatment options, complications, and outcomes in patients with non-saccular aneurysms of cerebral arteries belonging to type 1 and type 4 according to Mizutani’s classification. Methods A total of 26 aneurysms in 26 patients were treated between 2014 and 2019. There were 13 males (mean age 42.77 ± 11.73 years) and 13 females (mean age 50.84 ± 9.37 years). In 23 cases the onset was haemorrhagic and in three cases non-haemorrhagic. A combination of conventional stents and coils was used in 10 cases, conventional stents and flow diverters in three cases, flow diverters and coils in five cases, and flow diverters only were used in eight cases. Radiological results of treatment were assessed after eight months and clinical after one year. Results In 24 patients, aneurysms were occluded at the end of the follow-up period. An iatrogenic dissection and two haemorrhagic complications were registered. In three cases, parent arteries were occluded due to re-growth of the aneurysm, which caused middle cerebral artery infarction in one case. A favourable clinical outcome was registered in 19, patients, and non-favourable in five. Two patients died in the early postoperative period due to extensive damage to the brain parenchyma caused by initial bleeding. Conclusion Our results indicate that treatment of type 1 and type 4 non-saccular aneurysms with various combination of stents and flow diverters, with or without coils, is promising, although very challenging and technically demanding.