bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Tithonia diversifolia, Alchornea cordifolia, and Mezoneuron benthamianum on Tomato (Lycopersicon esculuntum) Nursery in Daloa (Côte d’Ivoire)
Authors: Guettia Marie Yah N’ , Marie Hélène Koffi Ahébé , N’goran Anderson Zadjei , Doffou Sélastique Akaffou , Hortense Diallo Atta Taky 
Published: October 2021

Aims: Research of alternative solutions to the use of synthetic pesticides.
Study Design : Randomized block.
Place and Duration of Study: Jean Lorougnon Guédé University (Daloa, Côte d’Ivoire), January to February 2020.
Methodology: Extracts of Alchornea cordifolia, Tithonia diversifolia and Mezoneuron benthamianum were evaluated in vitro and in the nursery at 5 g/l, 15 g/l and 25 g/l. In vitro, the blotting paper method was used on tomato seed germination. In the nursery, the powdery extracts were added to the nursery soil bags with four treatments (5 g/l, 15 g/l, 25 g/l and control) and six bags per treatment with five tomato seeds per bag. Germination rate, number of leaves, height and the health status of the plants as well as the incidence and severity of root galls were evaluated. The results showed that in vitro the control had the highest average germination rate (98.5%) followed by T. diversifolia (43.03 to 98.5%), A. cordifolia (35.33 to 68.67%) and M. benthamianum (37.66 to 67.55%). However, in the nursery, T. diversifolial recorded the highest average treated seed germination (38 to 78.33%) and seedling emergence (12.78 to 38.33%) rates compared to the other treatments. Concerning growth parameters, the number of leaves (5.38 to 13.21) and height (5.71 to 15.64 cm) of tomato plants were influenced by the extracts type and concentration. The incidence of root galls was low for treated plants (0-60%) compared to controls (100%). The severity of the galls was significantly reduced by the extracts, however the extracts of T. diversifolia were the most effective. Extracts were more effective at low concentrations in improving agromorphological parameters of tomato, in contrast to the incidence and severity of galls which were reduced at high concentrations. Results suggest that these locally available plants could be used as biofertilizers and control method against root-knot nematodes.
Formulation and Evaluation of Liquisolid Compacts of BCS Class II Drug Ketoprofen
Authors: Kasturi Madhavi , Malviya Neelesh 
Published: October 2021

Aims: The main objective of the current research work is to develop liquisolid compacts of BCS Class II drug ketoprofen with an intention to enhance the solubility of drug by applying liquisolid technique.
Place and Duration of Study: Smriti College of Pharmaceutical Education between June 2018 June 2019.
Methodology: Initially liquid medication was obtained by dissolving drug in suitable solvent. Saturation solubility studies were performed in various hydrophilic non-volatile solvents to select the solvent showing highest solubility for drug. This liquid medication was admixed with calculated amounts of carrier material (Avicel PH 102) and coating material (Cab-O-Sil) using Spireas mathematical model in order to obtain liquisolid formulations. Further, this powder mass of liquisolid system was compressed to form Ketoprofen liquisolid compact formulations ranging from TK1 to TK9. They were further subjected to post compression evaluation tests such as weight variation, hardness, friability, content uniformity, disintegration and in vitro dissolution studies.
Results: Based on the solubility studies, PEG 400 was selected as solvent for ketoprofen drug. Rheological properties for the prepared liquisolid powder system were performed for all the formulations and they showed acceptable flow properties. The results obtained for the post compression evaluation tests of all the prepared liquisolid compacts were present within the acceptable limits. The disintegration time observed for all formulations were within 5 minutes. The results of in vitro release of all the liquisolid compacts showed enhanced release rates compared to that of directly compressed tablet. Lquisolid compact formulation TK7 showed maximum release of 97.62% of drug within 12 minutes in pH 7.4 phosphate buffer which was much higher when compared to that of directly compressed tablet. The SEM and PXRD studies for TK7 revealed conversion of crystalline to molecularly dispersed form of drug in the obtained liquisolid formulation. DSC and FTIR studies also revealed that there was no presence of any significant interaction between drug and excipients involved in the formulation.
Conclusion: Finally, it could be concluded that Liquisolid technique was successful in enhancing the solubility and further dissolution profile of BCS Class II drug Ketoprofen.
Evaluation of Problems Comforted by Dental Professionals, Post Graduate and Interns Owing to use to the use of Personal Protective Equipments in Vidarbha Region
Authors: Kalbhut Vaishnav , Chhabra Kumar Gaurav , Reche Amit , Madhu Priyanka Paul , Arora Nakul , Varma Malaika 
Published: October 2021

Background: Dentist and dental students are facing problems while and after using the PPE Objectives: To analyse and provide a qualitative and quantitative evaluation of the problems facing dentist and dental students while and after using the PPE.
Methodology: It is a descriptive study which includes demographic details of the individuals and 25 questions regarding the problems faced by dental professionals, Post Graduates and Interns due to the use of PPE while performing the procedure and after achieving the procedure. Those who will acknowledge being part of the study will be sent an interface to the survey, either through e-mail or whatsapp mobile application. The submission shape will be kept open for a period of 30 days.
Expected Results: The expected results of this study will determine the difficulties encountered by Dentist, Postgraduates and Interns while and after using the PPE kits.
Conclusion: An observational based study in which we have to identify problems while and after using the PPE.
Estimation of Urinary Calcium as a Predictor of Pregnancy Induced Hypertension
Authors: Giresh Shoba 
Published: October 2021

Hypertensive diseases are still a leading cause of death among mothers all over the world. It’s complicated aetiology, which begins with aberrant placentation and ends with endothelial dysfunction, is yet unknown. The goal of this study is to learn about changes in serum and urine calcium levels in women who have Gestational Hypertension. 200 normotensive pregnant women between 24-28 weeks were included in the study based on inclusion and exclusion criteria. Urine calcium and creatinine and serum uric acid, total protein, albumin and serum sodium were estimated in corresponding samples collected from patients. The study showed a sensitivity of 80%, specificity of 71%, positive predictive value was 77%, negative predictive value 74%, and diagnostic accuracy as 74%. A single estimation of calcium to creatinine ratio in asymptomatic pregnant women between 24-28 week of gestation is a simple and cost-effective test.
Formulation and Toxicity Evaluation of Nanostructured Lipid Carriers for the Treatment of Acne
Authors: Lala Rita , Nandvikar Nikita 
Published: October 2021

Background: Acne vulgarise is an inflammatory disease involving the pathological alteration of the sebaceous glands of the body. It is not a life-threatening disease but has a great influence on lifestyle. Topical combination therapy of vitamin A and antibacterial drugs is an effective treatment for acne.
Materials and Methods: The current work investigates the nanostructure lipid colloidal carrier system of Tretinoin and Clindamycin phosphate. Nanostructured lipid carriers (NLCs) were prepared by highspeed homogenization-sonication technique and characterized for physicochemical properties, permeation, in vivo anti-acne and toxicity (acute 2000 mg/Kg, repeat 1000 mg/kg) in Wistar rats.
Results: The prepared system was found to be stable, homogenous with more site retention of drugs having non-irritation and toxicity potential. The formulation showed a size of 283 nm, polydispersity index (PDI) 0.43 and Zeta potential (ZP) -37.9 mV with drug entrapment 92.0% and 66.15% for tretinoin and clindamycin respectively. Observed permeation was 18 % and 45% for Tretinoin and Clindamycin less than marketed formulation which is more focused on dermal retention of drug. No significant abnormalities and toxicological symptoms were observed for acute and repeat dose toxicity study for histopathology and haematological examinations of organs.
Conclusion: Prepared NLC formulation was aimed at epidermal targeting. Based on obtained results it is concluded that developed lipid-based nanocarrier system of selected drugs showed the targeting potential for effective acne treatment.
Inflammatory Arthritis and the Effect of Physical Activity on Quality of Life and Self‐Reported Function: A Systematic Review and Meta‐Analysis
Authors: Björk Mathilda , Dragioti Elena , Alexandersson Helene , Esbensen Bente Appel , Boström Carina , Friden Cecilia , Hjalmarsson Sara , Hörnberg Kristina , Kjeken Ingvild , Regardt Malin , Sundelin Gunnevi , Sverker Annette , Welin Elisabet , Brodin Nina 
Published: October 2021

ObjectiveAlthough physical activity is an evidence‐based intervention that reduces disease‐related symptoms and comorbidity in rheumatoid arthritis (RA), the effect of physical activity on self‐reported function and quality of life (QoL) has not yet been analyzed. The present study synthesizes the evidence for the effectiveness of physical activity on QoL and self‐reported function in adults with RA, spondyloarthritis (SpA), and psoriatic arthritis (PsA).MethodsThe databases PubMed, Embase, CINAHL, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched to identify relevant randomized controlled trials (RCTs). Screening, risk of bias assessment (using the RoB 2.0 tool), and data extraction were independently performed by 2 or more of the authors. Meta‐analyses were conducted with a random‐effects model.ResultsSystematic review included 55 RCTs, and meta‐analysis included 37 RCTs. Of the 55 studies included, 76%, 20%, and 4% were designed to investigate RA, SpA, and PsA, respectively. In the RA studies, effects of physical activity on QoL and function were found compared to the group of inactive controls; no effects were found compared to the group of active controls. In the SpA studies, the effects of physical activity on QoL were in favor of the control group. Effects of physical activity on function were found compared to the group of inactive controls and sustained in fatigue and pain when compared to the group of active controls. In the PsA studies, no effects on QoL were found, but effects on function were noted when compared to the group of inactive controls. The effect size was below 0.30 in the majority of the comparisons.ConclusionPhysical activity may improve QoL and self‐reported function in individuals with RA, SpA, and PsA. However, larger trials are needed, especially in SpA and PsA.
Cyclometalated Pt(II)‐Terpyridine Metallomesogen: What Is Visible or Invisible That Is a Matter of Molecular Packing and Orientation
Authors: Kang Dong‐Gue , Rim Minwoo , Ryu Ki‐Hyun , Lee Kyung Min , Godman Nicholas P. , McConney Michael E. , De Sio Luciano , Park Minwook , Kim Dae‐Yoon , Jeong Kwang‐Un 
Published: October 2021

AbstractAn anisotropic light emitting metallomesogen (PtM) consisting of a cyclometalated platinum(II)–terpyridine (Pt(II)–tpy) chromophore and a flexible dendron is newly synthesized as a thermal‐induced and polarization‐induced solid‐state luminescence switching material. The self‐assembled PtM is uniaxially aligned by mechanical shearing within the mesophase resulting in high optical anisotropy with chromophores. The shear‐induced metastable PtM crystal exhibits emission change depending on the polarization direction and thermally triggered reversible emission quenching‐recovery characteristic. In order to precisely control the optical feature of the PtM, the self‐assembled supramolecular structure and thermal‐sensitive photophysical properties are characterized. Based on the multiresponsive luminescence switching system of PtM, a multiplexed optical code is encrypted with a simple coating and its feasibility for optical anticounterfeiting applications is demonstrated.
Synthesis of Amphiphilic Silica with High Exposure of Surface Groups and Its Utilization in Efficient Removal of Organic Dyes from Aqueous Solution
Authors: Yang Yuanyuan , Qiu Zhenhao , Weng Guoying , Wang Huibin , Li Yanshuo , Fan Benhan , Bai Xiu , Zhang Qiaohong , Chen Chen 
Published: October 2021

AbstractAmphiphilic silica is synthesized with the simultaneous introduction of two kinds of polar and weakly polar organic groups on its surface using a one‐step reverse‐phase microemulsion method. The obtained materials present as nanospheres with a size of ≈100 nm. A high percentage (≈80%) of silicon species can be exposed and the amount of surface SiOH increased by above 50% with the introduction of organic groups. Plenty of groups, including polar groups (3‐aminopropyl and hydroxyl) and weakly polar group (n‐propyl) coexisting on the surface, enable the material to show amphiphilicity. This amphiphilic material can show an excellent property for the removal of various organic dyes from the aqueous solution, and the maximum adsorption capacity of Congo Red, Acid Blue 25, Reactive Blue 19, and Reactive Black 5 can reach 2453.1, 1157.7, 964.6, and 916.9 mg g−1, respectively. Good reusability is also realized for the present amphiphilic material, which can be reused for at least three times. The reported work provides a successful example to prove that the surface hydrophilicity and lipophilicity can be simultaneously improved just through a simple introduction of certain organic groups, and then realize efficient removal of dyes from the polluted water.
1D/3D Heterogeneous Assembling Body as Trifunctional Electrocatalysts Enabling Zinc–Air Battery and Self‐Powered Overall Water Splitting
Authors: Zhou Guizhong , Liu Guishan , Liu Xiaobin , Yu Qingping , Mao Huimin , Xiao Zhenyu , Wang Lei 
Published: October 2021

AbstractDeveloping low‐cost, efficient, and stable trifunctional electrocatalyst for oxygen reduction reaction (ORR), oxygen evolution reaction (OER), and hydrogen evolution reaction (HER) is still a significant challenge. Herein, this study reports a zeolitic imidazolate framework (ZIF) derived trifunctional electrocatalyst, composed of Co5.47N and Co7Fe3 (CoFeN) that embedded into 1D N‐doped carbon nanotubes modified 3D cruciform carbon matrix (NCNTs//CCM). Benefiting from the robust interfacial conjugation of Co5.47N/Co7Fe3 and the 1D/3D hierarchical structure with a large surface area, the as‐prepared CoFeN‐NCNTs//CCM display trifunctional electrocatalytic activity for ORR (half‐wave potential of 0.84 V), OER (320 mV at 10 mA cm–2), and HER (−151 mV at 10 mA cm–2). The assembled Zn‐air battery exhibits high power density (145 mW cm–2), enhanced charge–discharge performance (voltage gap of 0.76 V at 10 mA cm–2), and long‐term cycling stability (over 445 h). The resultant overall water‐splitting cell achieves a current density of 10 mA cm–2 at 1.63 V, which can compete with the best reported trifunctional catalysts. What is more, the self‐assembled Zn‐air batteries are utilized to power the overall water splitting successfully, verifying great potential of the CoFeN‐NCNTs//CCM as functional material for sustainable energy storage and conversion system.
Tuning Hydrogels by Mixing Dynamic Cross‐Linkers: Enabling Cell‐Instructive Hydrogels and Advanced Bioinks
Authors: Morgan Francis L. C. , Fernández‐Pérez Julia , Moroni Lorenzo , Baker Matthew B. 
Published: October 2021

AbstractRational design of hydrogels that balance processability and extracellular matrix (ECM) biomimicry remains a challenge for tissue engineering and biofabrication. Hydrogels suitable for biofabrication techniques, yet tuneable to match the mechanical (static and dynamic) properties of native tissues remain elusive. Dynamic covalent hydrogels possessing shear‐thinning/self‐healing (processability) and time‐dependent cross‐links (mechanical properties) provide a potential solution, yet can be difficult to rationally control. Here, the straightforward modular mixing of dynamic cross‐links with different timescales (hydrazone and oxime) is explored using rheology, self‐healing tests, extrusion printing, and culture of primary human dermal fibroblasts. Maintaining a constant polymer content and cross‐linker concentration, the stiffness and stress relaxation can be tuned across two orders of magnitude. All formulations demonstrate a similar flow profile after network rupture, allowing the separation of initial mechanical properties from flow behavior during printing. Furthermore, the self‐healing nature of hydrogels with high hydrazone content enables recyclability of printed structures. Last, a distinct threshold for cell spreading and morphology is observed within this hydrogel series, even in multi‐material constructs. Simple cross‐linker mixing enables fine control and is of general interest for bioink development, targeting viscoelastic properties of specific cellular niches, and as an accessible and flexible platform for designing dynamic networks.
Precise Subcellular Organelle Targeting for Boosting Endogenous‐Stimuli‐Mediated Tumor Therapy
Authors: Zhen Wenyao , An Shangjie , Wang Shuqi , Hu Wenxue , Li Yujie , Jiang Xiue , Li Jinghong 
Published: October 2021

AbstractThough numerous external‐stimuli‐triggered tumor therapies, including phototherapy, radiotherapy, and sonodynamic therapy have made great progress in cancer therapy, the low penetration depth of the laser, safety concerns of radiation, the therapeutic resistance, and the spatio‐temporal constraints of the specific equipment restrict their convenient clinical applications. What is more, the inherent physiological barriers of the tumor microenvironment (TME), including hypoxia, heterogeneity, and high expression of antioxidant molecules also restrict the efficiency of tumor therapy. As a result, the development of nanoplatforms responsive to endogenous stimuli (such as glucose, acidic pH, cellular redox events, and etc.) has attracted great attention for starvation therapy, ion therapy, prodrug‐mediated chemotherapy, or enzyme‐catalyzed therapy. In addition, nanomedicines can be modified by some targeted units for precisely locating in subcellular organelles and boosting the destroying of tumor tissue, decreasing the dosage of nanoagents, reducing side effects, and enhancing the therapeutic efficiency. Herein, the properties of the TME, the advantages of endogenous stimuli, and the principles of subcellular‐organelle‐targeted strategies will be emphasized. Some necessary considerations for the exploitation of precision medicine and clinical translation of multifunctional nanomedicines in the future are also pointed out.
Spacer Cation Alloying in Ruddlesden–Popper Perovskites for Efficient Red Light‐Emitting Diodes with Precisely Tunable Wavelengths
Authors: Qing Jian , Ramesh Sankaran , Xu Qiang , Liu Xiao‐Ke , Wang Heyong , Yuan Zhongcheng , Chen Zhan , Hou Lintao , Sum Tze Chien , Gao Feng 
Published: October 2021

AbstractPerovskite light‐emitting diodes (PeLEDs) have recently shown significant progress with external quantum efficiencies (EQEs) exceeding 20%. However, PeLEDs with pure‐red (620−660 nm) light emission, an essential part for full‐color displays, remain a great challenge. Herein, a general approach of spacer cation alloying is employed in Ruddlesden–Popper perovskites (RPPs) for efficient red PeLEDs with precisely tunable wavelengths. By simply tuning the alloying ratio of dual spacer cations, the thickness distribution of quantum wells in the RPP films can be precisely modulated without deteriorating their charge‐transport ability and energy funneling processes. Consequently, efficient PeLEDs with tunable emissions between pure red (626 nm) and deep red (671 nm) are achieved with peak EQEs up to 11.5%, representing the highest values among RPP‐based pure‐red PeLEDs. This work opens a new route for color tuning, which will spur future developments of pure‐red or even pure‐blue PeLEDs with high performance.
Microbially Catalyzed Biomaterials for Bone Regeneration
Authors: Li Mengmeng , Ma Hongshi , Han Fei , Zhai Dong , Zhang Bingjun , Sun Yuhua , Li Tian , Chen Lei , Wu Chengtie 
Published: October 2021

AbstractBone is a complex mineralized tissue composed of various organic (proteins, cells) and inorganic (hydroxyapatite, calcium carbonate) substances with micro/nanoscale structures. To improve interfacial bioactivity of bone‐implanted biomaterials, extensive efforts are being made to fabricate favorable biointerface via surface modification. Inspired by microbially catalyzed mineralization, a novel concept to biologically synthesize the micro/nanostructures on bioceramics, microbial‐assisted catalysis, is presented. It involves three processes: bacterial adhesion on biomaterials, production of CO32− assisted by bacteria, and nucleation and growth of CaCO3 nanocrystals on the surface of bioceramics. The microbially catalyzed biominerals exhibit relatively uniform micro/nanostructures on the surface of both 2D and 3D α‐CaSiO3 bioceramics. The topographic and chemical cues of the grown micro/nanostructures present excellent in vitro and in vivo bone‐forming bioactivity. The underlying mechanism is closely related to the activation of multiple biological processes associated with bone regeneration. The study offers a microbially catalytic concept and strategy of fabricating micro/nanostructured biomaterials for tissue regeneration.
Enzyme Therapeutic for Ischemia and Reperfusion Injury in Organ Transplantation
Authors: Yan Ran , Ren Jie , Wen Jing , Cao Zheng , Wu Di , Qin Meng , Xu Duo , Castillo Roxanne , Li Feifei , Wang Fang , Gan Zhihua , Liu Chaoyong , Wei Ping , Lu Yunfeng 
Published: October 2021

AbstractIschemia–reperfusion injury (IRI) remains as a critical challenge for organ transplantation. Herein, an enzyme therapeutic based on superoxide dismutase and catalase for effective mitigation of IRI and pathogen‐induced liver injury is reported, providing a therapeutic for organ transplantation and other diseases.
An Ultrarobust and High‐Performance Rotational Hydrodynamic Triboelectric Nanogenerator Enabled by Automatic Mode Switching and Charge Excitation
Authors: Fu Shaoke , He Wencong , Tang Qian , Wang Zhao , Liu Wenlin , Li Qianying , Shan Chuncai , Long Li , Hu Chenguo , Liu Hong 
Published: October 2021

AbstractThe triboelectric nanogenerator (TENG) is an emerging technology for ambient mechanical energy harvesting, which provides a possibility to realize wild environment monitoring by self‐powered sensing systems. However, TENGs are limited in some practical applications as a result of their low output performance (low charge density) and mechanical durability (material abrasion). Herein, an ultrarobust and high‐performance rotational TENG enabled by automatic mode switching (contact mode at low speed and noncontact at high speed) and charge excitation is proposed. It displays excellent stability, maintaining 94% electrical output after 72 000 cycles, much higher than that of the normal contact‐mode TENG (30%). Due to its high electrical stability and large electrical output, this TENG powers 944 green light‐emitting diodes to brightness in series. Furthermore, by harvesting water‐flow energy, various commercial capacitors can be charged quickly, and a self‐powered fire alarm and self‐powered temperature and humidity detection are realized. This work provides an ideal scheme for enhancing the mechanical durability, broadening the range of working frequency, and improving the electrical output of TENGs. In addition, the high‐performance hydrodynamic TENG demonstrated in this work will have great applications for Internet of Things in remote areas.