bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feature selection using self-information and entropy-based uncertainty measure for fuzzy neighborhood rough set
Authors: Xu Jiucheng , Yuan Meng , Ma Yuanyuan 
Published: April 2021

AbstractFeature selection based on the fuzzy neighborhood rough set model (FNRS) is highly popular in data mining. However, the dependent function of FNRS only considers the information present in the lower approximation of the decision while ignoring the information present in the upper approximation of the decision. This construction method may lead to the loss of some information. To solve this problem, this paper proposes a fuzzy neighborhood joint entropy model based on fuzzy neighborhood self-information measure (FNSIJE) and applies it to feature selection. First, to construct four uncertain fuzzy neighborhood self-information measures of decision variables, the concept of self-information is introduced into the upper and lower approximations of FNRS from the algebra view. The relationships between these measures and their properties are discussed in detail. It is found that the fourth measure, named tolerance fuzzy neighborhood self-information, has better classification performance. Second, an uncertainty measure based on the fuzzy neighborhood joint entropy has been proposed from the information view. Inspired by both algebra and information views, the FNSIJE is proposed. Third, the K–S test is used to delete features with weak distinguishing performance, which reduces the dimensionality of high-dimensional gene datasets, thereby reducing the complexity of high-dimensional gene datasets, and then, a forward feature selection algorithm is provided. Experimental results show that compared with related methods, the presented model can select less important features and have a higher classification accuracy.
Deep Regularized Discriminative Network
Authors: Sultana Nazneen N. , Mandal Bappaditya , Puhan N. B. 
Published: April 2021

AbstractTraditional linear discriminant analysis (LDA) approach discards the eigenvalues which are very small or equivalent to zero, but quite often eigenvectors corresponding to zero eigenvalues are the important dimensions for discriminant analysis. We propose an objective function which would utilize both the principal as well as nullspace eigenvalues and simultaneously inherit the class separability information onto its latent space representation. The idea is to build a convolutional neural network (CNN) and perform the regularized discriminant analysis on top of this and train it in an end-to-end fashion. The backpropagation is performed with a suitable optimizer to update the parameters so that the whole CNN approach minimizes the within class variance and maximizes the total class variance information suitable for both multi-class and binary class classification problems. Experimental results on four databases for multiple computer vision classification tasks show the efficacy of our proposed approach as compared to other popular methods.
Early-life gut microbiota development from maternal vertical transmission
Authors: Wang Jing , Lin Li 
Published: April 2021

AbstractThe gut microbiota of early life is crucial for childhood growth and development. Maternal gut microbiota directly or indirectly affects the colonization and development of early-life gut microbiota. Factors such as delivery mode, feeding mode, gestational age at birth, diet, and antibiotic use, can influence the vertical transmission of maternal gut microbiota to infants and affect the development of metabolic, endocrine, neural, and immune pathways in the early life. In this review, we summarize the latest knowledge of factors affecting early-life gut microbiota from maternal vertical transmission.
Just doing their job: the hidden meteorologists of colonial Hong Kongc.1883–1914
Authors: Williamson Fiona 
Published: April 2021

AbstractThis article investigates the contribution made by indigenous employees to the work of the Hong Kong Observatory from its inception and into the early twentieth century. As has so often been the case in Western histories of science, the significance of indigenous workers and of women in the Hong Kong Observatory has been obscured by the stories of the government officials and observatory director(s). Yet without the employees, the service could not have functioned or grown. While the glimpses of their work and lives are fleeting, often only revealed in minor archival references, this article seeks to interrogate these sources to make these workers’ lives visible and to offer an examination of everyday working relationships at this place and point in time. It focuses on three areas. First, an exploration of who these workers were, and the role they played at the observatory. Second, an investigation of their contribution to the nascent science of meteorology. Third, an examination of available evidence – levels of high staff turnover, complaints, instances of foot dragging, or working to rule, as well as the tenacity to continue for years under difficult working conditions – to demonstrate the ability of workers to reject or to negotiate with colonial/patriarchal authority. In profiling their stories, this article will add to the literature examining the lives of scientific workers and their contributions to science, the everyday cultural and social contexts of colonial meteorology, and the role of ordinary men and women in producing meteorological knowledge at this time.
Improving Primary Health Care for Residents Living in Assisted Living: Evidence for Practice and Policy
Authors: Cann Patricia , McCloskey Rose 
Published: April 2021

ABSTRACTThe fact that there is a large and growing number of older Canadians has generated a sense of urgency in improving seniors’ access to health and long-term care services. Many provincial health care systems have engaged in a range of reforms to help older adults remain healthy and independent. Although many transformational changes have taken place across Canada to improve primary care, variations exist across provinces and territories in terms of older adults’ access to primary health care. Opportunities exist for provinces to learn from successful reforms implemented in other Canadian jurisdictions. Residents of assisted living (AL) facilities are an ideal group to whom to target primary health care reforms, given the important role these facilities play in the care continuum and the complex needs of their residents. Allowing practitioners to practice to their full scope and assume greater responsibility within the health care system is a strategy adopted in some jurisdictions with success. This article reports on reforms that have been made to expand the scopes of practice of nurse practitioners and paramedics in some provinces, but also have the potential to improve access to primary health care for those living in AL across the entire country, including those living in smaller provinces such as New Brunswick.
High Levels of CO2 Exchange During Synoptic‐Scale Events Introduce Large Uncertainty Into the Arctic Carbon Budget
Authors: Jentzsch K. , Schulz A. , Pirk N. , Foken T. , Crewell S. , Boike J. 
Published: April 2021

AbstractCO2 release from thawing permafrost is both a consequence of, and a driver for, global warming, making accurate information on the Arctic carbon cycle essential for climate predictions. Eddy covariance data obtained from Bayelva (Svalbard) in 2015, using well‐established processing and quality control techniques, indicate that most of the annual net CO2 uptake is due to high CO2 flux events in winter that are associated with strong winds and probably relate to technical limitations of the gas analyzer. Emission events may relate to either (unidentified) instrumental limitations or to physical processes such as CO2 advection. Excluding the high winter uptake events yields an annual CO2 budget close to zero; whether or not these events are included can, therefore, have a considerable effect on carbon budget calculations. Further investigation will be crucial to pinpoint the factors causing these high CO2 flux events and to derive scientifically substantiated flux processing standards.
Apparent Periodic and Long‐Term Changes in AAIW and UCDW Properties at Fixed Depths in the Southwest Pacific, With Indications of a Regime Shift in the 1930s
Authors: Thresher Ronald E. , Fallon Stewart J. 
Published: April 2021

AbstractMetal/calcium ratios in two long‐lived deep‐sea gorgonian corals (Lepidisis and Corallium spp.) in the Southwest Pacific evidence periodic decadal variability at depths that correspond to Antarctic Intermediate Water (AAIW) and shallow Upper Circumpolar Deep Water, and a shift in the mid‐1930s to late‐1930s in mean ambient temperatures, barium/silicate concentrations and possibly pH, the rate at which these properties change over time, and the relationship between temperatures at fixed depth and the Southern Annular Mode (SAM). The decadal periodicity, which is evident in other biological indices in the study area, can be accounted for by water mass heave on the order of 100–150 m, which is consistent with observed scales of variability in the AAIW. The proximate and ultimate causes of the midcentury shifts are unclear, but could be related to suggested mid‐20th century changes in climate parameters globally and, more specifically, in the subpolar SW Pacific.
Tracing Bank Storage and Hyporheic Exchange Dynamics Using 222Rn: Virtual and Field Tests and Comparison With Other Tracers
Authors: Liao Fu , Cardenas M. Bayani , Ferencz Stephen B. , Chen Xiaobing , Wang Guangcai 
Published: April 2021

AbstractDynamic hydrologic exchange flows in river beds and banks are important for many ecosystem functions throughout river corridors. Here we test whether the exchanges and the associated mixing between a flooding river and groundwater within the river’s bank can be effectively traced by Radon‐222 (222Rn), a naturally occurring, inert, radiogenic, and radioactive gas that can be analyzed and monitored in situ. The assessment was done by simulation of groundwater flow and reactive transport of 222Rn in the bank following a single, relatively rapid (hours long) flood wave and auxiliary field observations of 222Rn, temperature and total dissolved solids (a surrogate for any ionic conservative tracer). Results illustrate that 222Rn is more effective than temperature and total dissolved solids in tracing dynamic hyporheic exchange. 222Rn variations in space and time are larger than the analytical uncertainty of common measurement methods. The individual effects of aquifer hydraulic conductivity, dispersivity, river water 222Rn concentration, and bank topography were analyzed through sensitivity analysis. Larger hydraulic conductivity and dispersivity, lower 222Rn concentration in river water relative to groundwater, and gentler bank slopes resulted in a more prominent and traceable 222Rn signal. The transport and residence time of exchanged water may be estimated and interpreted using reactive transport models such as those implemented here. However, such application is sensitive to fluctuations in river water 222Rn, requiring it to be well characterized. The assessment provides guidance for using 222Rn as a tracer for groundwater and surface water interactions in dynamic settings.
Plant Roots Steer Resilience to Perturbation of River Floodplains
Authors: Bau' Valentina , Borthwick Alistair G. L. , Perona Paolo 
Published: April 2021

AbstractFreshwater ecosystems along river floodplains host among the greatest biodiversity on Earth and are known to respond to anthropic pressure. For water impounded systems, resilience to changes in the natural flow regime is believed to be bidirectional. Whether such resilience prevents the system from returning to pristine conditions after the flow regime changes reverse is as yet unclear, though widely documented. In this work, we show that temporal irreversibility of river floodplains to recover their status may be explained by the dynamics of riparian water‐tolerant plant roots. Our model is a quantitative tool that will benefit scientists and practitioners in predicting the impact of changing flow regimes on long‐term river floodplain dynamics.
The brain at war: effects of stress on brain structure in soldiers deployed to a war zone
Authors: Kühn Simone , Butler Oisin , Willmund Gerd , Wesemann Ulrich , Zimmermann Peter , Gallinat Jürgen 
Published: April 2021

AbstractIn search of the neural basis of severe trauma exposure and post-traumatic stress disorder (PTSD), a multitude of cross-sectional studies have been conducted, most of them pointing at structural deficits in the hippocampus and medial prefrontal cortex including the anterior cingulate cortex (ACC) and ventromedial prefrontal cortex (vmPFC). Since cross-sectional studies are silent to causality, the core question remains: which brain structural alterations constitute a risk factor for disease and therewith precede the stressor, and which brain regions may undergo alterations as a consequence of exposure to the stressor. We assessed 121 soldiers before and after deployment to regions of war and 40 soldiers as controls, who were not deployed. Analysis using voxel-based morphometry revealed volumetric reductions in the ACC, vmPFC (region of interest analysis, effect does not survive conservative multiple test correction) and in bilateral thalamus (whole-brain analysis) in the deployment group. Remarkably, the ACC and vmPFC volume decrease was not limited to the period of deployment, but continued over the following 6 months after deployment. Volumetric reductions did not correlate with increases in PTSD symptoms. The volume decreases in medial prefrontal cortex and thalamus seem to be driven by trauma exposure rather than a vulnerability factor for PTSD. However, data indicate that the volume decrease in medial prefrontal cortex surpasses the time period of deployment. This may hint at an initiated pathobiological process below a symptom threshold, potentially paving the way to future mental health problems.
Toll-like receptor 4-mediated cytokine synthesis and post-stroke depressive symptoms
Authors: Korostynski Michal , Hoinkis Dzesika , Piechota Marcin , Golda Slawomir , Pera Joanna , Slowik Agnieszka , Dziedzic Tomasz 
Published: April 2021

AbstractAltered cytokine synthesis thought to contribute to the pathophysiology of post-stroke depression (PSD). Toll-like receptor 4 (TLR4) is a master regulator of innate immunity. The aim of this study was to explore the putative association between TLR4-mediated cytokine synthesis and subsequent symptoms of PSD. In total, 262 patients with ischemic stroke and without a history of PSD were included. Depressive symptoms were assessed using the Patient Health Questionnaire-9 in 170 patients on Day 8 and in 146 at 3 months after stroke. Blood samples taken on Day 3 after stroke were stimulated ex vivo with lipopolysaccharide (LPS). Ex vivo synthesized cytokines (TNFα, IP-10, IL-1β, IL-6, IL-8, IL-10, and IL-12p70) and circulating cytokines (TNFα, IL-6, sIL-6R, and IL-1ra) were measured using the enzyme-linked immunoassay or cytometric method. RNA sequencing was used to determine the gene expression profile of LPS-induced cytokines and chemokines. LPS-induced cytokine synthesis and the gene expression of TLR4-dependent cytokines and chemokines did not differ between patients with and without greater depressive symptoms. The plasma level of IL-6, but not TNFα, sIL-6R, and IL-1ra, was higher in patients who developed depressive symptoms at 3 months after stroke (median: 4.7 vs 3.4 pg/mL, P = 0.06). Plasma IL-6 predicted the severity of depressive symptoms at 3 months after stroke (β = 0.42, P = 0.03). In conclusion, TLR4-dependent cytokine synthesis was not associated with greater post-stroke depressive symptoms in this study. Circulating IL-6 might be associated with depressive symptoms occurring at 3 months after stroke.
Novel multi-strain probiotics reduces Pasteurella multocida induced fowl cholera mortality in broilers
Authors: Reuben Rine Christopher , Sarkar Shovon Lal , Ibnat Habiba , Setu Md. Ali Ahasan , Roy Pravas Chandra , Jahid Iqbal Kabir 
Published: April 2021

AbstractPasteurella multocida causes fowl cholera, a highly contagious poultry disease of global concern, causing significant ecological and economic challenges to the poultry industry each year. This study evaluated the effects of novel multi-strain probiotics consisting of Lactobacillus plantarum, L. fermentum, Pediococcus acidilactici, Enterococcus faecium and Saccharomyces cerevisiae on growth performance, intestinal microbiota, haemato-biochemical parameters and anti-inflammatory properties on broilers experimentally challenged with P. multocida. A total of 120 birds were fed with a basal diet supplemented with probiotics (108 CFU/kg) and then orally challenged with 108 CFU/mL of P. multocida. Probiotics supplementation significantly (P < 0.05) improved growth performance and feed efficiency as well as reducing (P < 0.05) the population of intestinal P. multocida, enterobacteria, and mortality. Haemato-biochemical parameters including total cholesterol, white blood cells (WBC), proteins, glucose, packed cell volume (PCV) and lymphocytes improved (P < 0.05) among probiotic fed birds when compared with the controls. Transcriptional profiles of anti-inflammatory genes including hypoxia inducible factor 1 alpha (HIF1A), tumor necrosis factor- (TNF) stimulated gene-6 (TSG-6) and prostaglandin E receptor 2 (PTGER2) in the intestinal mucosa were upregulated (P < 0.05) in probiotics fed birds. The dietary inclusion of the novel multi-strain probiotics improves growth performance, feed efficiency and intestinal health while attenuating inflammatory reaction, clinical signs and mortality associated with P. multocida infection in broilers.
Prostaglandin F2α agonists induced enhancement in collagen1 expression is involved in the pathogenesis of the deepening of upper eyelid sulcus
Authors: Itoh Kaku , Ida Yosuke , Ohguro Hiroshi , Hikage Fumihito 
Published: April 2021

AbstractPrevious our study reported that three-dimension (3D) cultures of human orbital fibroblasts (HOFs) replicated the etiology of deepening of the upper eyelid sulcus (DUES) caused by prostaglandin F2α analogues (PGF2α-ags). To examine this further, the effects of PGF2α-ags on HOFs were characterized by (1) lipid staining (2D; two-dimension, 3D), (2) comparison of the 3D organoid sizes of preadipocytes (DIF−) or adipocytes (DIF+) that had been treated with various concentrations of several PGF2α-ags, (3) physical stiffness (3D), and (4) the mRNA expression of adipogenic related genes, extracellular matrix (ECM), tissue inhibitors of metalloproteinases (TIMPs) and matrix metalloproteinases (MMPs) (3D). PGF2α-ags caused a dramatic down-sizing of the 3D DIF+ organoids and this reduction was concentration dependent. The effects caused by PGF2α-ags were also observed in 3D preadipocytes. Micro-squeezer analysis clearly indicated that PGF2α-ags induced an increase in their physical solidity. The size of each organoid under several conditions was inversely correlated with the mRNA expression profile of collagen1 (COL1), TIMP2, and MMP2 and 9. These findings indicate that PGF2α-ags affect the expression of COL1, TIMP2, and MMP2 and 9 which, in turn, modulate the 3D ECM network within the organoids, thus resulting in their downsizing.
Differences in Daily Voice Use Measures Between Female Patients With Nonphonotraumatic Vocal Hyperfunction and Matched Controls
Authors: Van Stan Jarrad H. , Ortiz Andrew J. , Cortes Juan P. , Marks Katherine L. , Toles Laura E. , Mehta Daryush D. , Burns James A. , Hron Tiffiny , Stadelman-Cohen Tara , Krusemark Carol , Muise Jason , Fox-Galalis Annie B. , Nudelman Charles , Zeitels Steven , Hillman Robert E. 
Published: April 2021

Purpose
The purpose of this study was to obtain a more comprehensive understanding of the pathophysiology and impact on daily voice use of nonphonotraumatic vocal hyperfunction (NPVH).

Method

An ambulatory voice monitor collected 1 week of data from 36 patients with NPVH and 36 vocally healthy matched controls. A subset of 11 patients with NPVH were monitored after voice therapy. Daily voice use measures included neck-skin acceleration magnitude, fundamental frequency (
f
o
), cepstral peak prominence (CPP), and the difference between the first and second harmonic magnitudes (H1–H2). Additional comparisons included 118 patients with phonotraumatic vocal hyperfunction (PVH) and 89 additional vocally healthy controls.

Results

The NPVH group, compared to the matched control group, exhibited increased
f
o
(Cohen's
d
= 0.6), reduced CPP (
d
= −0.9), and less positive H1–H2 skewness (
d
= −1.1). Classifiers used CPP mean and H1–H2 mode to maximally differentiate the NPVH and matched control groups (area under the receiver operating characteristic curve of 0.78). Classifiers performed well on unseen data: the logit decreased in patients with NPVH after therapy; ≥ 85% of the control and PVH groups were identified as “normal” or “not NPVH,” respectively.

Conclusions

The NPVH group's daily voice use is less periodic (CPP), is higher pitched (
f
o
), and has less abrupt vocal fold closure (H1–H2 skew) compared to the matched control group. The combination of CPP mean and H1–H2 mode appears to reflect a pathophysiological continuum in NPVH patients of inefficient phonation with minimal potential for phonotrauma. Further validation of the classification model is needed to better understand potential clinical uses.

Supplemental Material

https://doi.org/10.23641/asha.14390771
Thickness dependent electrical resistivity modulation in tensile-strained epitaxial thin films of calcium manganese oxide
Authors: Hart Cacie , Warecki Zoey , Yong Grace , Houston David , Kolagani Rajeswari 
Published: April 2021

We report our studies of the thickness dependence of electrical resistivity and lattice constants in strained epitaxial thin films of calcium manganese oxide. Our results indicate the potential of bi-axial lattice mismatch strain as a handle for modulating electrical resistivity. We observe thickness dependence of lattice constants consistent with what is expected for strain relaxation for films thicker than 400 Å. At lower thickness values, anomalies are observed suggestive of reduced oxygen stoichiometry. We observe a remarkable decrease in electrical resistivity with decreasing film thickness. The resistivity of our thinnest films (5–7 nm) is about three orders of magnitude lower than the resistivity of bulk CaMnO3. Resistivity increases as the film thickness increases, along with the progression of strain relaxation. It is noteworthy that the thickness dependence of resistivity we observe in CMO thin films is the opposite of what has been reported for their hole-doped rare earth manganite counterpart La0.67Ca0.33MnO3 (LCMO), where tensile lattice mismatch strain suppresses metallicity, leading to the increase in resistivity with film thickness. We believe that the enhanced conductivity in our thinnest films is related to the possible oxygen deficiency promoted by tensile strain. Recent x-ray absorption measurements have revealed reduced oxygen content and associated changes in Mn valence states in tensile-strained CMO thin films, as also predicted by density functional theory calculations. This report is the first observation of electrical transport behavior possibly indicative of strain–oxygen stoichiometry coupling.