bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cuidados dos enfermeiros obstetras com as gestantes no pré- parto em uma maternidade municipal de Teresina-PI
Authors: Silva Lycia Tainá Lima e , Fonseca Marina Ribeiro da , Santana Rosane da Silva , Alcântara Francisco Ricardo de , Reis Mariana Libório Dourado , Pereira Ana Cristina Ferreira , Gonçalves Regivane Silva Costa , Sousa Elizama Costa dos Santos , Galvão Tatiana Custódio das Chagas Pires , Oliveira Cristiana Pacífico , Barbosa Miralice Medeiros Ferreira , Pereira Maria das Graças Nunes , Araujo Erilayne Thais de 
Published: April 2021

Para que o parto ocorra de modo natural é necessário que não haja intercorrências ou procedimentos desnecessários. Para evitar complicações, os enfermeiros devem planejar uma assistência humanizada e efetiva com cuidados individualizados voltados para cada situação vivenciada pela mulher durante todas as fases do parto. O estudo tem como objetivo analisar os cuidados dos enfermeiros obstetras com as gestantes no pré-parto em uma maternidade municipal de Teresina-PI. Trata-se de um estudo qualitativo com abordagem descritiva desenvolvido em uma Maternidade pública no município de Teresina-PI nos meses de agosto a outubro de 2018. Participaram da pesquisa oito enfermeiros obstetras em exercício de sua função. Foram incluídos os enfermeiros com especialização em obstetrícia e que assistem diretamente as gestantes no pré-parto e; excluídos apenas os que estavam de férias ou licença durante a realização da pesquisa. Utilizou-se um roteiro semiestruturado para coleta dos dados e, para análise, foi aplicada a técnica de Análise de Conteúdo. Evidenciou-se que os enfermeiros atuam de forma ampla desde a admissão, orientando sobre o processo do trabalho de parto e suas fases, até os cuidados exercidos durante o pré-parto estimulando para que a gestante tenha dilatação rápida e com dor diminuída. É necessário que os enfermeiros exerçam princípios de humanização da assistência, valorizem o acolhimento, a prática de ouvir a paciente e a relação respeitosa entre profissionais/clientes. Espera-se com o estudo contribuir com a expansão da atividade dos enfermeiros obstetras, e na busca da qualidade dos serviços e principalmente com atendimento integral a mulher durante o trabalho de parto.
SISTEM PENDUKUNG KEPUTUSAN PEMILIHAN DOSEN BERPRESTASI JURUSAN TEKNOLOGI INFORMASI DI POLITEKNIK NEGERI MALANG
Authors: Ervin Vidi Wicahya  , Dwi Puspitasari  , Ananta Ahmadi Yuli 
Published: April 2021

Penilaian prestasi dosen merupakan salah satu kegiatan yang diadakan setiap semester pada Jurusan Teknologi Informasi di Politeknik Negeri Malang. Kegiatan ini bertujuan untuk memberikan penghargaan pada Dosen sesuai dengan UU No 14 tahun 2005 tentang Guru dan Dosen, Pasal 51 Ayat (1) Butir b, bahwa Dosen berhak mendapatkan penghargaan sesuai dengan kinerja akademiknya. Pada Jurusan Teknologi Informasi penilaian prestasi dosen merupakan salah satu kegiatan yang diadakan setiap semester di Politeknik Negeri Malang. Adapun data kriteria yang dijadikan sebagai dasar penilaian yaitu kehadiran dosen, pengumpulan nilai, pengumpulan soal ujian, penilaian mahasiswa, jurnal, seminar, penelitian dan pengabdian kepada masyarakat. Untuk saat ini setiap dosen di Jurusan Teknologi Informasi harus memberikan secara langsung data penilaian tersebut dan admin harus menjumlahkan semua nilai yang terkumpul dari setiap dosen yang pada akhirnya membutuhkan waktu yang cukup lama dalam perhitungannya. Sehingga itu menjadi suatu permasalahan yang harus segera diselesaikan. Untuk mengatasi permasalahan tersebut maka dirancang sebuah sistem pendukung keputusan untuk pemilihan dosen berprestasi menggunakan Metode Simple Additive Weighting (SAW). Hasil akhir dari penelitian ini sistem dapat menampilkan hasil perangkingan untuk membantu dalam menentukan dosen berprestasi Jurusan Teknologi Informasi di Politeknik Negeri Malang, dengan cara menghitung dan memproses nilai prioritas atau bobot yang ditentukan dari setiap kriteria data yang dimasukkan.
Kata Kunci : SPK, pemilihan dosen berprestasi, metode SAW
Identification of Seven-Gene Hypoxia Signature for Predicting Overall Survival of Hepatocellular Carcinoma
Authors: Bai Yuping , Qi Wenbo , Liu Le , Zhang Jing , Pang Lan , Gan Tiejun , Wang Pengfei , Wang Chen , Chen Hao 
Published: April 2021

BackgroundHepatocellular carcinoma (HCC) is ranked fifth among the most common cancer worldwide. Hypoxia can induce tumor growth, but the relationship with HCC prognosis remains unclear. Our study aims to construct a hypoxia-related multigene model to predict the prognosis of HCC.MethodsRNA-seq expression data and related clinical information were download from TCGA database and ICGC database, respectively. Univariate/multivariate Cox regression analysis was used to construct prognostic models. KM curve analysis, and ROC curve were used to evaluate the prognostic models, which were further verified in the clinical traits and ICGC database. GSEA analyzed pathway enrichment in high-risk groups. Nomogram was constructed to predict the personalized treatment of patients. Finally, real-time fluorescence quantitative PCR (RT-qPCR) was used to detect the expressions of KDELR3 and SCARB1 in normal hepatocytes and 4 HCC cells. The expressions of SCARB1 in hepatocellular carcinoma tissue in 46 patients were detected by immunohistochemistry, and the correlation between its expressions and disease free survival of patient was calculated.ResultsThrough a series of analyses, seven prognostic markers related to HCC survival were constructed. HCC patients were divided into the high and low risk group, and the results of KM curve showed that there was a significant difference between the two groups. Stratified analysis, found that there were significant differences in risk values of different ages, genders, stages and grades, which could be used as independent predictors. In addition, we assessed the risk value in the clinical traits analysis and found that it could accelerate the progression of cancer, while the results of GSEA enrichment analysis showed that the high-risk group patients were mainly distributed in the cell cycle and other pathways. Then, Nomogram was constructed to predict the overall survival of patients. Finally, RT-qPCR showed that KDELR3 and SCARB1 were highly expressed in HepG2 and L02, respectively. Results of IHC staining showed that SCARB1 was highly expressed in cancer tissues compared to adjacent normal liver tissues and its expression was related to hepatocellular carcinoma differentiation status. The Kaplan-Meier survival showed a poor percent survival in the SCARB1 high group compared to that in the SCARB1 low group.ConclusionThis study provides a potential diagnostic indicator for HCC patients, and help clinicians to deepen the comprehension in HCC pathogenesis so as to make personalized medical decisions.
A Pilot Study on the Cutoff Value of Related Brain Metabolite in Chinese Elderly Patients With Mild Cognitive Impairment Using MRS
Authors: Zhao Lihua , Teng Jinlong , Mai Wei , Su Jiahui , Yu Bihan , Nong Xiucheng , Li Chong , Wei Yichen , Duan Gaoxiong , Deng Xiangming , Deng Demao , Chen Shangjie 
Published: April 2021

Objective: This cross-sectional study aimed to distinguish patients with mild cognitive impairment (MCI) from patients with normal controls (NCs) by measuring the levels of N-acetyl aspartate (NAA), total creatinine (tCr), and choline (Cho) in their hippocampus (HIP) and their posterior cingulate gyrus (PCG) by using proton magnetic resonance spectroscopy (MRS) and to predict the cutoff value on the ratios of metabolites. We further aimed to provide a reference for the diagnosis of MCI in elderly patients in China.Methods: About 69 patients who underwent a clinical diagnosis of the MCI group and 67 patients with NCs, the Mini-Mental Status Examination (MMSE) score, the Montreal Cognitive Assessment (MoCA) score, and MRS of the bilateral HIP and bilateral PCG were considered. The ratio of NAA/tCr and Cho/tCr in the bilateral HIP and bilateral PCG was calculated. The relationship between the ratios of metabolites and the scores of MMSE and MoCA was analyzed, and the possible brain metabolite cutoff point for the diagnosis of MCI was evaluated.Results: Compared with the NC group, the scores of MMSE and MoCA in the MCI group decreased significantly (p &lt; 0.05); the ratio of NAA/tCr in the bilateral HIP and bilateral PCG and the ratio of Cho/tCr at the right HIP in the MCI group decreased significantly (p &lt; 0.05); however, there was no significant difference in the ratio of Cho/tCr in the left HIP and bilateral PCG between the two groups (p &gt; 0.05). The correlation coefficient between MMSE/MoCA and the ratio of NAA/tCr was 0.49–0.56 in the bilateral HIP (p &lt; 0.01). The best cutoff value of NAA/creatine (Cr) in the left HIP and the right HIP was 1.195 and 1.19. Sensitivity, specificity, and the Youden index (YDI) in the left HIP and the right HIP were (0.725, 0.803, 0.528) and (0.754, 0.803, 0.557), respectively.Conclusion: The level of metabolites in the HIP and the PCG of patients with MCI and of those with normal subjects has a certain correlation with the score of their MMSE and MoCA. When the value of NAA/tCr in the left HIP and right HIP is &lt;1.19, it suggests that MCI may have occurred. According to this cutoff point, elderly patients with MCI in China could be screened.
The Need for Structured Strategies to Improve Stroke Care in a Rural Telestroke Network in Northern New South Wales, Australia: An Observational Study
Authors: Kashida Yumi Tomari , Garcia-Esperon Carlos , Lillicrap Thomas , Miteff Ferdinand , Garcia-Bermejo Pablo , Gangadharan Shyam , Chew Beng Lim Alvin , O'Brien William , Evans James , Alanati Khaled , Bivard Andrew , Parsons Mark , Majersik Jennifer Juhl , Spratt Neil James , Levi Christopher ,   The members of Northern NSW Telestroke investigators for this project
Published: April 2021

Introduction: A telestroke network in Northern New South Wales, Australia has been developed since 2017. We theorized that the telestroke network development would drive a progressive improvement in stroke care metrics over time.Aim: This study aimed to describe changes in acute stroke workflow metrics over time to determine whether they improved with network experience.Methods: We prospectively collected data of patients assessed by telestroke who received multimodal computed tomography (mCT) and were diagnosed with ischemic stroke or transient ischemic attack from January 2017 to July 2019. The period was divided into two phases (phase 1: January 2017 – October 2018 and phase 2: November 2018 – July 2019). We compared median door-to-call, door-to-image, and door-to-decision time between the two phases.Results: We included 433 patients (243 in phase 1 and 190 in phase 2). Each spoke site treated 1.5–5.2 patients per month. There were Door-to-call time (median 39 in phase 1, 35 min in phase 2, p = 0.18), and door-to-decision time (median 81.5 vs. 83 min, p = 0.31) were not improved significantly. Similarly, in the reperfusion therapy subgroup, door-to-call time (median 29 vs. 24.5 min, p = 0.12) and door-to-decision time (median 70.5 vs. 67.5 min, p = 0.75) remained substantially unchanged. Regression analysis showed no association between time in the network and door-to-decision time (coefficient 1.5, p = 0.32).Conclusion: In our telestroke network, acute stroke timing metrics did not improve over time. There is the need for targeted education and training focusing on both stroke reperfusion competencies and the technical aspects of telestroke in areas with limited workforce and high turnover.
Dietary Inflammatory Index Is Associated With Inflammation in Japanese Men
Authors: Kotemori Ayaka , Sawada Norie , Iwasaki Motoki , Yamaji Taiki , Shivappa Nitin , Hebert James R. , Ishihara Junko , Inoue Manami , Tsugane Shoichiro 
Published: April 2021

Background: Dietary components are known to affect chronic low-grade inflammation status. The dietary inflammatory index (DII®) was developed to measure the potential impact of a diet on an individual's inflammatory status, and it has been validated mainly in Western countries.Objective: This study aimed to examine the validity of the energy-adjusted DII (E-DIITM) using high-sensitivity C-reactive protein (hs-CRP) concentration in Japanese men and women.Methods: In total, 6,474 volunteers from a cancer-screening program (3,825 men and 2,649 women) completed a food frequency questionnaire (FFQ) and their hs-CRP concentrations were evaluated. E-DII scores were calculated on the basis of 30 food parameters derived from the FFQ. Higher E-DII scores reflect a greater pro-inflammatory potential of the diet. The associations between E-DII quartiles and hs-CRP concentration were assessed using regression models adjusted for age, body mass index, smoking status, and amount of physical activity.Results: Mean E-DII in men and women was + 0.62 ± 1.93 and −1.01 ± 2.25, respectively. The proportion of men and women who had hs-CRP concentration &gt;3 mg/L was 4.7 and 3.1%, respectively. A significant positive association was observed between E-DII score and hs-CRP concentration in men; geometric mean of hs-CRP concentration in the lowest and highest E-DII quartiles was 0.56 mg/L and 0.67 mg/L (Ptrend &lt; 0.01), respectively. The odds ratio (95% confidence interval) of having an elevated hs-CRP concentration (&gt;3 mg/L) was 1.72 (1.10–2.67) in the highest E-DII quartile (Ptrend = 0.03) in men. However, no association was observed between E-DII score and hs-CRP concentration in women, except in those not taking prescription medications.Conclusions: DII was associated with inflammation status in Japanese men, but the association was limited in Japanese women.
Prevalence and Stigma of Postpartum Common Mental Disorders in the Gurage Region of Ethiopia: A Mixed-Methods Observational Cohort Study
Authors: Monaghan Sophia , Akale Meseret Ayalew , Demeke Bete , Darmstadt Gary L. 
Published: April 2021

Objectives: Mental disorders are vastly underdiagnosed in low-income countries that disproportionately affect women. We aimed to evaluate the prevalence of common mental disorders in newly postpartum women, and stigma associated with mental health reporting in an Ethiopian community using a validated World Health Organization survey.Methods: The Self Reporting Questionnaire (SRQ) for psychological distress was administered in Amharic by nurses to 118 women aged 18–37 years who had given birth in the prior 3 months in the Glenn C. Olsen Memorial Primary Hospital in Yetebon. Mental health stigma among the four nursing staff was assessed using Link and Phelan's Components of Stigma.Results: Among 118 women surveyed, 18% had a probable common mental disorder using the SRQ 4/5 cutoff and 2% admitted to suicidal thoughts. Presence of stigma in the healthcare staff was verified, including labeling, stereotyping, separating, and status loss and discrimination.Conclusion: Postpartum mental health disorders as well as stigma against such diagnoses are common in the Yetebon community. There is an urgent need for increased availability of properly trained and supervised healthcare staff in the identification and referral of postpartum women with common mental disorders.
Cyberbullying Among School Adolescents in an Urban Setting of a Developing Country: Experience, Coping Strategies, and Mediating Effects of Different Support on Psychological Well-Being
Authors: Ngo Anh Toan , Tran Anh Quynh , Tran Bach Xuan , Nguyen Long Hoang , Hoang Men Thi , Nguyen Trang Huyen Thi , Doan Linh Phuong , Vu Giang Thu , Nguyen Tu Huu , Do Hoa Thi , Latkin Carl A. , Ho Roger C. M. , Ho Cyrus S. H. 
Published: April 2021

Background: This study examined the cyberbullying experience and coping manners of adolescents in urban Vietnam and explored the mediating effect of different support to the associations between cyberbullying and mental health issues.Methods: A cross-sectional study was performed on 484 students at four secondary schools. Cyberbullying experience, coping strategies, psychological problems, and family, peer, and teacher support were obtained. Structural equation modeling was utilized to determine the mediating effects of different support on associations between cyberbullying and psychological problems.Results: There were 11.6 and 28.3% of students who reported that they experienced and observed at least one cyberbullying act in the last 3 months, respectively. Among the victims, only 48.2% tried to stop the perpetrators. Meanwhile, the majority of observers belonged to the “Intervene” group who tried to report cyberbullying acts or help victims. Family support was found to partially mediate associations between cyberbullying experience and observation with levels of psychological problems among adolescents.Conclusion: The 3-month rate of cyberbullying experience and observation among urban adolescents aged 11–14 was low. However, current coping strategies against cyberbullying were not sufficient. Family support is an important factor that should be considered for designing interventions to mitigating the impacts of cyberbullying on the mental health of adolescents.
Mental Symptoms and Stress of Hospitalized Schizophrenia Patients With 2019 Novel Coronavirus Disease: An Observation Study
Authors: Ma Jun , Jiang Tao , Huang Hanjun , Li Ruihua , Zhang Lin , Liu Lianzhong , Liu Xuebing 
Published: April 2021

Background: The 2019 novel coronavirus disease (COVID-19) is an extremely rapidly spreading respiratory infection caused by SARS-CoV-2. Many schizophrenic patients were infected with COVID-19 in Wuhan City, Hubei Province. This study took hospitalized schizophrenia patients with COVID-19 as the research subjects and observed the changes in psychopathology and stress of patients with COVID-19 and the accompanying social isolation.Methods: To sort and isolate potential COVID-19-infected patients, an isolated ward was set up from January 30, 2020, to March 30, 2020. Schizophrenia patients with COVID-19 were referred to this ward, and long-term hospitalized cases were included in this study. The Positive and Negative Syndrome Scale and Perceived Stress Scale were used to evaluate the severity of mental symptoms and psychological stress in the early stage of the outbreak of COVID-19, after the diagnosis of COVID-19 and after recovery. At the time of diagnosis, we also extracted the patient's routine blood, biochemical and other indicators and asked the patient's perception of COVID-19.Results: 21 hospitalized schizophrenia patients with COVID-19 were recruited in this study. The changes in PANSS scores were not significant (p = 0.225 baseline vs. diagnosed, p = 0.399 cured vs. diagnosed). The CPSS scores increased significantly after diagnosis and transfer to the isolation ward (p &lt; 0.001 baseline vs. diagnosed, p &lt; 0.001 cured vs. diagnosed). The course of schizophrenia was a protective factor of stress levels to cases (t = −3.25, p = 0.006), and patients' perception of COVID-19 was a risk factor (t = 2.48, p = 0.038). The final multiple linear regression model was statistically significant (F = 8.16, p &lt; 0.001).Conclusion: Hospitalized schizophrenia patients with COVID-19 had increased stress levels and negative symptoms but alleviated positive symptoms after medical isolated treatment. This reminds us that in the face of major epidemics, we must specifically alleviate the psychological burden at the peak of the epidemic and improve the prognosis of patients after the epidemic.
The Relationship Between Different Aspects of Theory of Mind and Symptom Clusters in Psychotic Disorders: Deconstructing Theory of Mind Into Cognitive, Affective, and Hyper Theory of Mind
Authors: Dorn Laura M.-L. , Struck Nele , Bitsch Florian , Falkenberg Irina , Kircher Tilo , Rief Winfried , Mehl Stephanie 
Published: April 2021

Background:Several meta-analyses highlight pronounced problems in general Theory of Mind (ToM), the ability to infer other persons' mental states, in patients with psychosis in comparison to non-clinical controls. In addition, first studies suggest associations between Hyper-ToM, an exaggerated inference of mental states to others, and delusions. Research on different ToM subtypes (Cognitive ToM, Affective ToM, and Hyper-ToM) and symptom clusters of psychosis (positive, negative, and disorganized symptoms) have gathered conflicting findings. Thus, the present study examined group differences between patients with psychosis and non-clinical controls concerning Cognitive ToM/Affective ToM and Hyper-ToM. Further, the association between ToM subtypes and symptom clusters (positive, negative, and disorganized symptoms) were examined.Methods:Patients with psychotic disorders (n= 64, 1/3 with present delusions indicated by a minimum score of four in thePANSSP1 item) and non-clinical controls (n= 21) were examined with assessments of Cognitive ToM and Affective ToM abilities and Hyper-ToM errors using the Frith-Happé animations. Psychopathology was assessed using the Positive and Negative Syndrome Scale.Results:Patients with psychosis presented more pronounced problems in Cognitive and Affective ToM in comparison to non-clinical controls, whereas there were no group differences with regard to Hyper-ToM errors. Furthermore, deficits in Cognitive ToM were associated with general delusions, whereas problems in Affective ToM were associated with negative and disorganized symptoms. In addition, there was no association between Hyper-ToM errors and any symptoms when controlling for years of education.Conclusions:Our findings suggest that deficits in ToM subtypes might not be directly related to delusions and positive symptoms and are in line with more recently developed cognitive models of delusions. In addition, our results support the well-established finding of associations between ToM alterations and negative or disorganized symptoms. Our results shed light on the role of different dimensions of ToM in specific symptoms of psychosis.
Hybrid Capture-based Genomic Profiling of Circulating Tumor DNA From Patients With Advanced Ovarian Cancer
Authors: Shen Wenbin , Shan Boer , Liang Shanhui , Zhang Junling , Yu Yangyang , Zhang Yuzi , Wang Guoqiang , Bai Yuezong , Qian Bing , Lu Jin , Jiang Zhi 
Published: April 2021

Objective: We conducted this study to characterize somatic genomic alterations in circulating tumor DNA (ctDNA) from patients with ovarian cancer and compare GAs detected in ctDNA with tissue databases.Methods: Hybrid capture-next generation sequencing genomic profiling of 150 genes was performed on ctDNA from 138 patients with ovarian cancer with 1,500× sequencing depth. The GAs detected in ctDNA were compared with those in our ovarian cancer tissue database (N = 488) and the Cancer Genome Atlas (TCGA) database (N = 489).Results: 115 patients (83%) had at least 1 GA detected in ctDNA. The most frequently altered genes detected in ctDNA were TP53 (72%), KRAS (11%), LRP1B (10%), ZNF703 (9%) and NF1 (8%). Comparative analysis with our tissue database showed similar frequencies of GAs per gene, although PIK3CA and KRAS mutations were more frequent in tissue and ctDNA, respectively (p &lt; 0.05). Gene amplification and rearrangement were more frequent in ctDNA samples. The mutation frequency of homologous recombination repair associated-genes, VEGF signal/angiogenesis pathways, RAS pathways, NOTCH pathways and MSI-H ratio was not statistically different either in ctDNA or in tissue database. However, the mutation frequency of AKT, PIK3CA, PTEN and STK11 in PI3K/AKT/mTOR pathway was significantly lower than that in tissue samples (p &lt; 0.05).Conclusions: Our results suggest that genomic profiling of ctDNA could detect somatic GAs in a significant subset of patients with ovarian cancer. Hybrid capture-NGS based on liquid biopsy has the potential capability to serve as a substitute to tissue biopsy and further studies are warranted.