bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imaging predictors of successful surgical treatment of hemifacial spasm
Authors: Hughes Marion A , Traylor Katie S , Branstetter IV Barton F , Eubanks Komal P , Chang Yue-Fang , Sekula Jr Raymond F 
Published: August 2021

Abstract
Identify preoperative imaging findings in hemifacial spasm patients that predict the post-surgical success following microvascular decompression. This is a retrospective study of patients who were diagnosed with hemifacial spasm, had a dedicated cranial nerve MRI, and underwent microvascular decompression for hemifacial spasm. Bilateral facial nerves were interrogated for neurovascular compression. If neurovascular compression was identified, we recorded whether the offending vessel was an artery, a vein or both. The location of the neurovascular compression (proximal nerve versus distal nerve) was noted. The severity of the neurovascular compression was categorized as contact versus deformity of the nerve. Patients were contacted to determine their post-operative spasm status. The relationships between imaging findings and post-surgical outcome were assessed by Chi-square tests, and odds ratios were calculated to quantify the degree of association. The study included 212 patients. Upon follow up, 192 patients were spasm free (90.57%). Imaging findings on the symptomatic side were as follows: arterial neurovascular compression was seen in 207 patients (97.64%), venous only neurovascular compression in two patients (0.94%), and no neurovascular compression in three patients (1.42%). Arterial neurovascular compression along the proximal, susceptible segment of the nerve was observed in 202 patients (95.28%); deformity was observed more commonly than contact alone. Arterial neurovascular compression along the distal segment only of the nerve was observed in five patients (2.36%). In patients with arterial neurovascular compression of the proximal and distal portions of the nerve, 93.07% and 60.0% of patients were spasm-free respectively. If venous neurovascular compression only was observed on imaging, 0% of patients were spasm-free. Patients with arterial neurovascular compression of the susceptible segment are much more likely to be spasm free than patients without this imaging finding, [odds ratio 20.14 (CI 5.08, 79.81), P-value &lt;0.0001]. When comparing the two groups of arterial neurovascular compression (deformity versus contact), no statistically significant difference in outcomes was observed. In patients with hemifacial spasm undergoing microvascular decompression, imaging findings do predict surgical outcome. Patients with arterial neurovascular compression of the proximal, susceptible portion of the nerve are much more likely to be spasm free after surgery than those without this imaging finding. The imaging findings inform the risk benefit analysis and discussion with patients before they undergo microvascular decompression for hemifacial spasm.
Reconciling Egg- and Antigen-Based Estimates of Schistosoma mansoni Clearance and Reinfection: A Modeling Study
Authors: Clark Jessica , Moses Arinaitwe , Nankasi Andrina , Faust Christina L , Moses Adriko , Ajambo Diana , Besigye Fred , Atuhaire Aaron , Wamboko Aidah , Carruthers Lauren V , Francoeur Rachel , Tukahebwa Edridah M , Prada Joaquin M , Lamberton Poppy H L 
Published: August 2021

Abstract

Background
Despite decades of interventions, 240 million people have schistosomiasis. Infections cannot be directly observed, and egg-based Kato-Katz thick smears lack sensitivity, affected treatment efficacy and reinfection rate estimates. The point-of-care circulating cathodic antigen (referred to from here as POC-CCA+) test is advocated as an improvement on the Kato-Katz method, but improved estimates are limited by ambiguities in the interpretation of trace results.

Method
We collected repeated Kato-Katz egg counts from 210 school-aged children and scored POC-CCA tests according to the manufacturer’s guidelines (referred to from here as POC-CCA+) and the externally developed G score. We used hidden Markov models parameterized with Kato-Katz; Kato-Katz and POC-CCA+; and Kato-Katz and G-Scores, inferring latent clearance and reinfection probabilities at four timepoints over six-months through a more formal statistical reconciliation of these diagnostics than previously conducted. Our approach required minimal but robust assumptions regarding trace interpretations.

Results
Antigen-based models estimated higher infection prevalence across all timepoints compared with the Kato-Katz model, corresponding to lower clearance and higher reinfection estimates. Specifically, pre-treatment prevalence estimates were 85% (Kato-Katz; 95% CI: 79%–92%), 99% (POC-CCA+; 97%–100%) and 98% (G-Score; 95%–100%). Post-treatment, 93% (Kato-Katz; 88%–96%), 72% (POC-CCA+; 64%–79%) and 65% (G-Score; 57%–73%) of those infected were estimated to clear infection. Of those who cleared infection, 35% (Kato-Katz; 27%–42%), 51% (POC-CCA+; 41%–62%) and 44% (G-Score; 33%–55%) were estimated to have been reinfected by 9-weeks.

Conclusions
Treatment impact was shorter-lived than Kato-Katz–based estimates alone suggested, with lower clearance and rapid reinfection. At 3 weeks after treatment, longer-term clearance dynamics are captured. At 9 weeks after treatment, reinfection was captured, but failed clearance could not be distinguished from rapid reinfection. Therefore, frequent sampling is required to understand these important epidemiological dynamics.
Public-Key Authenticated Encryption with Keyword Search: A Generic Construction and Its Quantum-Resistant Instantiation
Authors: Liu Zi-Yuan , Tseng Yi-Fan , Tso Raylin , Mambo Masahiro , Chen Yu-Chi 
Published: August 2021

Abstract
The industrial Internet of Things (IIoT) integrates sensors, instruments, equipment and industrial applications, enabling traditional industries to automate and intelligently process data. To reduce the cost and demand of required service equipment, IIoT relies on cloud computing to further process and store data. Public-key encryption with keyword search (PEKS) plays an important role, due to its search functionality, to ensure the privacy and confidentiality of the outsourced data and the maintenance of flexibility in the use of the data. Recently, Huang and Li proposed the ‘public-key authenticated encryption with keyword search’ (PAEKS) to avoid the insider keyword guessing attacks (IKGAs) in the previous PEKS schemes. However, all current PAEKS schemes are based on the discrete logarithm assumption and are therefore vulnerable to quantum attacks. In this study, we first introduce a generic PAEKS construction, with the assistance of a trusted authority, that enjoys the security against IKGA in the standard model, if all building blocks are secure under standard model. Based on the framework, we further propose a novel instantiation of quantum-resistant PAEKS that is based on NTRU assumption under random oracle. Compared with its state-of-the-art counterparts, the experiment result indicates that our instantiation is more efficient and secure.
MicroRNA-27b-3p down-regulates FGF1 and aggravates pathological cardiac remodelling
Authors: Li Guoqi , Shao Yihui , Guo Hong Chang , Zhi Ying , Qiao Bokang , Ma Ke , Du Jie , Lai Yong Qiang , Li Yulin 
Published: August 2021

Abstract

Aims
The heart undergoes pathological remodelling under increased stress and neuronal imbalance. MicroRNAs (miRNAs) are involved in post-transcriptional regulation of genes in cardiac physiology and pathology. However, the mechanisms underlying miRNA-mediated regulation of pathological cardiac remodelling remain to be studied. This study aimed to explore the function of endogenous microRNA-27b-3p (miR-27b-3p) in pathological cardiac remodelling.

Methods and results
miR-27b-3p expression was elevated in the heart of a transverse aortic constriction (TAC)-induced cardiac hypertrophy mouse model. miR-27b-knockout mice showed significantly attenuated cardiac hypertrophy, fibrosis, and inflammation induced by two independent pathological cardiac hypertrophy models, TAC and Angiotensin II (Ang II) perfusion. Transcriptome sequencing analysis revealed that miR-27b deletion significantly down-regulated TAC-induced cardiac hypertrophy, fibrosis, and inflammatory genes. We identified fibroblast growth factor 1 (FGF1) as a miR-27b-3p target gene in the heart which was up-regulated in miR-27b-null mice. We found that both recombinant FGF1 (rFGF1) and inhibition of miR-27b-3p enhanced mitochondrial oxidative phosphorylation (OXPHOS) and inhibited cardiomyocyte hypertrophy. Importantly, rFGF1 administration inhibited cardiac hypertrophy and fibrosis in TAC- or Ang II-induced models and enhanced OXPHOS by activating PGC1α/β.

Conclusions
Our study demonstrated that miR-27b-3p induces pathological cardiac remodelling and suggests that inhibition of endogenous miR-27b-3p or administration of FGF1 might have the potential to suppress cardiac remodelling in a clinical setting.
Using multimarker screening to identify biomarkers associated with cardiovascular death in patients with atrial fibrillation
Authors: Pol Tymon , Hijazi Ziad , Lindbäck Johan , Oldgren Jonas , Alexander John H , Connolly Stuart J , Eikelboom John W , Ezekowitz Michael D , Granger Christopher B , Lopes Renato D , Yusuf Salim , Siegbahn Agneta , Wallentin Lars 
Published: August 2021

Abstract

Aims
Atrial fibrillation (AF) is associated with higher mortality. Biomarkers may improve the understanding of key pathophysiologic processes in AF that lead to death. Using a new multiplex analytic technique, we explored the association between 268 biomarkers and cardiovascular (CV) death in anticoagulated patients with AF.

Methods and results
A case–cohort design with 1.8- to 1.9-year follow-up. The identification cohort included 517 cases and 4057 randomly selected patients from ARISTOTLE. The validation cohort included 277 cases and 1042 randomly selected controls from RE-LY. Plasma collected at randomization was analysed with conventional immunoassays and the OLINK proximity extension assay panels: CVDII, CVDIII, and Inflammation. Association between biomarkers and CV death was evaluated using Random Survival Forest, Boruta, and adjusted Cox-regression analyses. The biomarkers most strongly and consistently associated with CV death were as follows (hazard ratio for inter-quartile comparison [95% CI]): N-terminal pro-B-type natriuretic peptide [NT-proBNP; 1.63 (1.37–1.93)], cardiac troponin T [cTnT-hs; 1.60 (1.35–1.88)], interleukin-6 [IL-6; 1.29 (1.13–1.47)], growth differentiation factor-15 [GDF-15; 1.30 (1.10–1.53)], fibroblast growth factor 23 [FGF-23; 1.21 (1.10–1.33)], urokinase receptor [uPAR; 1.38 (1.16–1.64)], trefoil factor 3 [TFF3; 1.27 (1.10–1.46)], tumour necrosis factor receptor 1 [TNFR1; 1.21 (1.01–1.45)], TNF-related apoptosis-inducing ligand receptor 2 [TRAILR2; 1.18 (1.04–1.34)], and cathepsin L1 [CTSL1; 1.22 (1.07–1.39)].

Conclusion
In this comprehensive screening of 268 biomarkers in anticoagulated patients with AF, the underlying mechanisms most strongly associated with CV death were cardiorenal dysfunction (NT-proBNP, cTnT-hs, CTSL1, TFF3), oxidative stress (GDF-15), inflammation (IL-6, GDF-15), calcium balance, vascular and renal dysfunction (FGF-23), fibrinolysis (suPAR), and apoptosis (TNFR1, TRAILR2). These findings provide novel insights into pathophysiologic aspects associated with CV death in AF.

ClinicalTrials.gov identifier
NCT00412984 and NCT00262600.
Case report: acute myocarditis following the second dose of mRNA-1273 SARS-CoV-2 vaccine
Authors: Tailor Prashant D , Feighery Aoife M , El-Sabawi Bassim , Prasad Abhiram 
Published: August 2021

Abstract

Background
The SARS-CoV-2 pandemic has led to the development of the first mRNA vaccines used in humans. The vaccines are well tolerated, safe, and highly efficacious; however, post-marketing surveillance is revealing potential rare adverse effects. We report a case of symptomatic acute myocarditis following administration of the second dose of mRNA-1273 SARS-CoV-2 vaccine.

Case summary
A 44-year-old man presented with chest pain and ST-segment elevation 4 days after receiving the second dose of mRNA-1273 SARS-CoV-2 Vaccine. Emergent coronary angiogram showed minimal coronary artery disease. Cardiac magnetic resonance imaging confirmed acute myocarditis. Diagnosis of vaccine-associated myocarditis was made given the temporal relationship and supportive treatment initiated. Follow-up at 1 month confirmed complete symptomatic recovery and echocardiogram demonstrated normalization of cardiac function.

Discussion
Acute myocarditis should be considered in patients who present with chest pain or dyspnoea within days of receiving mRNA-1273 SARS-CoV-2 vaccination, especially after the second dose. This may be managed successfully with supportive therapies with complete recovery of cardiac function and symptoms. Further research is warranted to determine the mechanisms by which mRNA vaccines may cause myocarditis and for potential long-term cardiovascular injury.
Types of myocardial injury and mid-term outcomes in patients with COVID-19
Authors: Kini Annapoorna , Cao Davide , Nardin Matteo , Sartori Samantha , Zhang Zhongjie , Pivato Carlo Andrea , Chiarito Mauro , Nicolas Johny , Vengrenyuk Yuliya , Krishnamoorthy Parasuram , Sharma Samin K , Dangas George , Fuster Valentin , Mehran Roxana 
Published: August 2021

Abstract

Aims
To evaluate the acute and chronic patterns of myocardial injury among patients with coronavirus disease-2019 (COVID-19), and their mid-term outcomes.

Methods and results
Patients with laboratory-confirmed COVID-19 who had a hospital encounter within the Mount Sinai Health System (New York City) between 27 February 2020 and 15 October 2020 were evaluated for inclusion. Troponin levels assessed between 72 h before and 48 h after the COVID-19 diagnosis were used to stratify the study population by the presence of acute and chronic myocardial injury, as defined by the Fourth Universal Definition of Myocardial Infarction. Among 4695 patients, those with chronic myocardial injury (n = 319, 6.8%) had more comorbidities, including chronic kidney disease and heart failure, while acute myocardial injury (n = 1168, 24.9%) was more associated with increased levels of inflammatory markers. Both types of myocardial injury were strongly associated with impaired survival at 6 months [chronic: hazard ratio (HR) 4.17, 95% confidence interval (CI) 3.44–5.06; acute: HR 4.72, 95% CI 4.14–5.36], even after excluding events occurring in the first 30 days (chronic: HR 3.97, 95% CI 2.15–7.33; acute: HR 4.13, 95% CI 2.75–6.21). The mortality risk was not significantly different in patients with acute as compared with chronic myocardial injury (HR 1.13, 95% CI 0.94–1.36), except for a worse prognostic impact of acute myocardial injury in patients &lt;65 years of age (P-interaction = 0.043) and in those without coronary artery disease (P-interaction = 0.041).

Conclusion
Chronic and acute myocardial injury represent two distinctive patterns of cardiac involvement among COVID-19 patients. While both types of myocardial injury are associated with impaired survival at 6 months, mortality rates peak in the early phase of the infection but remain elevated even beyond 30 days during the convalescent phase.
Efficacy of a digital therapeutics system in the management of essential hypertension: the HERB-DH1 pivotal trial
Authors: Kario Kazuomi , Nomura Akihiro , Harada Noriko , Okura Ayako , Nakagawa Kiyose , Tanigawa Tomoyuki , Hida Eisuke 
Published: August 2021

Abstract

Aims
Digital therapeutics is a new approach to facilitate the non-pharmacological treatment of hypertension using software programmes such as smartphone applications and/or device algorithms. Based on promising findings from a small pilot trial, the HERB Digital Hypertension 1 (HERB-DH1) pivotal trial investigated the efficacy of digital therapeutics in patients with hypertension not receiving antihypertensive medication.

Methods and results
This prospective, open-label, randomized controlled study was performed at 12 sites in Japan. Patients with hypertension [office systolic blood pressure (SBP) 140 to &lt;180 mmHg and 24 h SBP ≥130 mmHg] were randomly assigned 1:1 to the digital therapeutics group (HERB system + standard lifestyle modification) or control group (standard lifestyle modification alone). The primary efficacy endpoint was the mean change in 24 h ambulatory SBP from baseline to 12 weeks; key secondary efficacy endpoints were mean changes in office and home blood pressure (BP) from baseline to 12 weeks. All analyses were conducted in the full analysis set population. Between December 2019 and June 2020, 390 patients were randomly assigned to the digital therapeutics group (n = 199) or control (n = 191) group. Between-group differences in 24-h ambulatory, home, and office SBPs at 12 weeks were −2.4 (95% confidence interval −4.5 to −0.3), −4.3 (−6.7 to −1.9), and −3.6 (−6.2 to −1.0) mmHg, respectively. No major programme-related safety events occurred up to 24 weeks.

Conclusion
The HERB-DH1 pivotal study showed the superiority of digital therapeutics compared with standard lifestyle modification alone to reduce 24-h ambulatory, home, and office BPs in the absence of antihypertensive medications.
Phenotypic heterogeneity in persisters: a novel ‘hunker’ theory of persistence
Authors: Urbaniec J , Xu Ye , Hu Y , Hingley-Wilson S , McFadden J 
Published: August 2021

ABSTRACT
Persistence has been linked to treatment failure since its discovery over 70 years ago and understanding formation, nature and survival of this key antibiotic refractory subpopulation is crucial to enhancing treatment success and combatting the threat of antimicrobial resistance (AMR). The term ‘persistence’ is often used interchangeably with other terms such as tolerance or dormancy. In this review we focus on ‘antibiotic persistence’ which we broadly define as a feature of a subpopulation of bacterial cells that possesses the non-heritable character of surviving exposure to one or more antibiotics; and persisters as cells that possess this characteristic. We discuss novel molecular mechanisms involved in persister cell formation, as well as environmental factors which can contribute to increased antibiotic persistence in vivo, highlighting recent developments advanced by single-cell studies. We also aim to provide a comprehensive model of persistence, the ‘hunker’ theory which is grounded in intrinsic heterogeneity of bacterial populations and a myriad of ‘hunkering down’ mechanisms which can contribute to antibiotic survival of the persister subpopulation. Finally, we discuss antibiotic persistence as a ‘stepping-stone’ to AMR and stress the urgent need to develop effective anti-persister treatment regimes to treat this highly clinically relevant bacterial sub-population.
Multiparameter viscoelastic full-waveform inversion of shallow-seismic surface waves with a pre-conditioned truncated Newton method
Authors: Gao Lingli , Pan Yudi , Rieder Andreas , Bohlen Thomas 
Published: August 2021

SUMMARY
2-D full-waveform inversion (FWI) of shallow-seismic Rayleigh waves has become a powerful method for reconstructing viscoelastic multiparameter models of shallow subsurface with high resolution. The multiparameter reconstruction in FWI is challenging due to the potential presence of cross-talk between different parameters and the unbalanced sensitivity of Rayleigh-wave data with respect to different parameter classes. Accounting for the inverse Hessian using truncated Newton methods based on second-order adjoint methods provides an effective tool to mitigate cross-talk caused by the coupling between different parameters. In this study, we apply a pre-conditioned truncated Newton (PTN) method to shallow-seismic FWI to simultaneously invert for multiparameter near-surface models (P- and S-wave velocities, attenuation of P and S waves, and density). We first investigate scattered wavefields caused by these parameters to evaluate the coupling between them. Then we investigate the performance of the PTN method on shallow-seismic FWI of Rayleigh wave for reconstructing all five parameters simultaneously. The application to spatially correlated and uncorrelated models demonstrates that the PTN method helps to mitigate the cross-talk and improves the resolution of the multiparameter reconstructions, especially for the weak parameters with small sensitivity such as attenuation and density parameters. The attenuation of Pwaves cannot be inverted reliably due to its negligible sensitivity on the Rayleigh wave. The comparison with the classical pre-conditioned conjugate gradient method highlights the improved performance of the PTN method and thus the benefit of accounting for the information included in the Hessian.
Opportunistic magnetotelluric transects from CSEM surveys in the Barents Sea
Authors: Corseri R , Planke S , Faleide J I , Senger K , Gelius L J , Johansen S E 
Published: August 2021

Summary
Magnetotelluric (MT) data allow for electrical resistivity probing of the Earth's subsurface. Integration of resistivity models in passive margin studies could help disambiguate non-unique interpretations of crustal composition derived from seismic and potential field data, a recurrent issue in the distal domain. In this contribution, we present the first marine MT data in the Barents Sea, derived from industrial controlled-source electromagnetic (CSEM) surveys. We characterize data quality, dimensionality, depth penetration and elaborate an analysis strategy. The extensive MT database consists of 337 receivers located along 7 regional transects, emanating from ∼70,000 km2 of 3D CSEM surveys acquired for hydrocarbon exploration from 2007 to 2019. High-quality MT data are extracted for periods ranging from 0.5 s to 5000 s. The data show no apparent contamination by the active source nor effects related to large time-gaps in data collection and variable solar activity. Along receiver profiles, abrupt lateral variations of apparent resistivity and phase trends coincide with major structural boundaries and underline the geological information contained in the data. Dimensionality analysis reveals a dichotomy between the western domain of the SW Barents Sea, dominated by a single N-S electromagnetic strike, and the eastern domain, with a two-fold, period-dependent strike. 35 receivers show 3D distortion caused by nearby bathymetric slopes, evidenced by elevated skew values. We delineate geographical areas where the 2D assumption is tenable and lay the foundation for future MT modelling strategies in the SW Barents Sea. We performed 2D MT inversion along one of the regional transects, a ∼220 km-long, E-W profile encompassing a major structural high and sedimentary basin approaching the continent-ocean transition. The resistivity model reveals low crustal resistivity values (1–10 Ω.m) beneath the deep sedimentary basins, in marked contrast with high resistivity values (1000–5000 Ω.m) of the thick crystalline crust on the structural high. We interpret this abrupt lateral resistivity variation as a rapid transition from a thick, dry continental crust to a hyperextended and hydrated crustal domain. Integration of resistivity with seismic velocity, density and magnetic susceptibility models may further refine these structural models and the underlying tectonic processes in the SW Barents Sea margin. Our methodology is applicable globally where 3D CSEM surveys are acquired and has a large potential for harvesting new knowledge on the electrical resistivity properties of the lithosphere.