bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shell morphology, growth and longevity of Unio tumidus (Bivalvia: Unionidae) from an archaeological site and contemporary population inhabiting the Oder estuary
Authors: Czerniejewski Przemysław , Dąbrowski Jarosław , Wawrzyniak Wawrzyniec , Brysiewicz Adam , Surma Orina 
Published: May 2021

AbstractMussel shells are often found in archaeological excavations and can provide information useful for ecological reconstruction and assessment of anthropogenic impact on waters. In this study, two sample groups of swollen river mussel (Unio tumidus) which occurred during the Early Middle Ages (EMS) and currently (MS) in the Oder river estuary (Baltic basin) were compared. Allometric shell growth, morphological characteristics of the shell (length, width, height and thickness), age structure and growth of mussels were analysed using the von Bertalanffy equation. All three types of allometric growth (isometry and both positive and negative allometry) were observed in the studied mussels. In both groups, typical values of shell length, width, height and thickness were recorded. However, higher values of these morphological characteristics were recorded in the EMS group. Moreover, the EMS group, compared with the MS group ofU. tumidus, was characterised by a higher longevity (12 and 10 years, respectively) and asymmetric length (L∞) (93.09 and 83.23 mm, respectively). Both groups of mussels had a similar growth rate (k). Larger shell sizes in the EMS group were probably caused by differential preservation and/or differential archaeological recovery, and resulted from differences in the age structure, especially higher mortality rate amongst individuals older than 6 years in the MS group.
Tissue reaction to novel customized calcium silicate cement based dental implants. A pilot study in the dog
Authors: Fakhrzadeh Amir , Saghiri Mohammad Ali , Morgano Steven M. , Sullivan Andrew 
Published: May 2021

Abstract
Objectives
The purpose of this study was to determine the level of periodontal tissue regeneration in a canine model following post-extraction placement of an implant molded from a composite material made from extracted tooth dentin and a calcium silicate cement (CSC) material. The investigation used autologous dentin in conjunction with a CSC material to form a composite implant designed for immediate tooth replacement.

Methods
Two (2) beagles had a periodontal and radiographic examination performed to rule out any pre-treatment inflammation, significant periodontal disease, or mobility. Then, ination eleven (11) teeth were extracted and polyvinyl siloxane molds were made to fabricate three different types of implants: Particulate Implant (Test Group 1, n = 4), Shell Implant Alone (Test Group 2, n = 2), Shell Implant with Emdogain® (Test Group 3, n = 3). Teeth in the control group were extracted, scaled (n = 2), and then re-implanted into their respective fresh extraction sockets. At 4 weeks, a clinical, radiographic, and histologic assessment was performed.

Results
Clinical evaluation revealed no mobility in any of the test or control implants and no radiographic evidence of significant bone loss or active disease. Based on the MicroCT analysis, direct bone to implant contact was observed in some areas with an apparent periodontal ligament space. Implant-related inflammation, on average, was similar among all groups, with low numbers of infiltrates. Implant-related inflammatory reaction was generally minimal and not interpreted to be adverse.

Conclusion
The proposed novel composite materials revealed that not only do these materials demonstrate high biocompatibility, but also their successful integration in the alveolus is likely secondary to a partial ligamentous attachment. The current investigation may lead to the use of calcium silicate-based materials as custom dental implants. Further research on this novel composite’s biomechanical properties is necessary to develop the optimal material composition for use as a load-bearing dental implant.
A higher-order parametric nonlinear reduced-order model for imperfect structures using Neumann expansion
Authors: Marconi J. , Tiso P. , Quadrelli D. E. , Braghin F. 
Published: May 2021

AbstractWe present an enhanced version of the parametric nonlinear reduced-order model for shape imperfections in structural dynamics we studied in a previous work. In this model, the total displacement is split between the one due to the presence of a shape defect and the one due to the motion of the structure. This allows to expand the two fields independently using different bases. The defected geometry is described by some user-defined displacement fields which can be embedded in the strain formulation. This way, a polynomial function of both the defect field and actual displacement field provides the nonlinear internal elastic forces. The latter can be thus expressed using tensors, and owning the reduction in size of the model given by a Galerkin projection, high simulation speedups can be achieved. We show that the adopted deformation framework, exploiting Neumann expansion in the definition of the strains, leads to better accuracy as compared to the previous work. Two numerical examples of a clamped beam and a MEMS gyroscope finally demonstrate the benefits of the method in terms of speed and increased accuracy.
Dynamics of HDI Index: Temporal Dependence Based on D-vine Copulas Model for Three-Way Data
Authors: Nai Ruscone Marta , Fernández Daniel 
Published: May 2021

AbstractThe HDI (Human Development Index) is a widely used index based on the average of measures of health, education, and income. It assesses the progress of countries worldwide. The publicly available data set associated with the HDI can be seen as a table with 3 dimensions (three-way table): countries, indexes regarding progress, and years (from 2010 to 2018). Thus, modeling the serial dependence structure of this type of intricate three-way tables is a challenge. D-vine copulas are a special class of multivariate copulas that are particularly suited for modeling serial dependence. This work aims to assess the evolution of the dependence relationship between the indexes of the HDI data set over time through D-vine copulas, which has not been fully used before in the area, as far as we are concerned. We tested our approach to European and African countries and compare their results.
The Salience of Perceived Societal Conflict in Europe: A 27 Country Study on the Development of a Measure for Generalized Conflict Thinking
Authors: van Drunen Yaël , Spruyt Bram , Van Droogenbroeck Filip 
Published: May 2021

AbstractOver the last two decades, European countries have struggled with several crises (e.g., the Great Recession, the refugee crisis) which had a tremendous impact on (some) societies. Typically, these crises were accompanied by divisive public discourses that rely heavily on a sharp and moralistic us-them distinction. Especially extreme right- and left-wing parties have adopted such conflict discourses and have gained much electoral support. Against this background, this paper has two objectives. First, data from the European Quality of Life Survey from 2003 to 2016 in 27 countries are used to provide a comprehensive overview of the salience of perceived societal conflicts between seven pairs of groups between countries and across time. We find substantial differences between countries and longitudinal trend variation in the salience of perceived societal conflict. For example, in Eastern European countries more economic conflict is perceived, while in Western European countries people perceive more cultural conflict between different ethnic and religious groups. Second, multigroup confirmatory factor analyses reveal that specific perceptions of conflict are structured by an underlying general orientation, generalized conflict thinking: people’s tendency to perceive society through the lens of conflict regardless of the specificity of these groups. The measure for generalized conflict thinking is metric equivalent across a large sample of countries. This demonstrates that generalized conflict thinking can be used as a social indicator for comparative research. In the conclusion we elaborate on the implications of our findings and develop a research agenda regarding generalized conflict thinking.
Two fatal and four surviving cases after accidental infusion of ropivacaine
Authors: Winkler Michaela , Alt Andreas , Dietzsch Susann , Kunz Sebastian N. 
Published: May 2021

Abstract
Purpose
In this paper, we describe six cases, where patients were falsely treated with pre-filled ropivacaine solution instead of medical saline solution for postoperative settings. Two of the patients died because of fatal concentrations of ropivacaine in blood, four survived with no further physical injury, and two of them showed typical intoxication symptoms. The collected blood and urine samples of the deceased, as well as the surviving patients, were analyzed in laboratory routine screening.

Methods
Ropivacaine and its main metabolite 3-OH-ropivacaine were analyzed by gas chromatography–mass spectrometry.

Results
All of the six cases showed positive blood results of ropivacaine. Due to the poorly secured sample material of the survived patients at hospital, the quantitative examination of 3-OH-ropivacaine could not be carried out. In one fatal case, there were ropivacaine and 3-OH-ropivacaine traceable in urine. In all cases, metamizole was found in blood and traces of piritramide in urine. The amount of metamizole was within the upper limits of therapeutical treatment values. Patients with lower blood concentrations of ropivacaine showed more physical symptoms as compared to those with higher concentrations of active substances.

Conclusions
In the context of symptom development and intoxication, the speed of injection was a very important factor to cause fatal ropivacaine cases. To our knowledge, these are the first reported cases of fatal intoxication with ropivacaine.
Individual 3D-printed fixation masks for radiotherapy: first clinical experiences
Authors: Mattke M. , Rath D. , Häfner M. F. , Unterhinninghofen R. , Sterzing F. , Debus J. , Giesel F. L. 
Published: May 2021

Abstract
Purpose
To show the feasibility of 3D-printed fixation masks for whole brain radiation therapy in a clinical setting and perform a first comparison to an established thermoplastic mask system.

Methods
Six patients were irradiated with whole brain radiotherapy using individually 3D-printed masks. Daily image guidance and position correction were performed prior to each irradiation fraction. The vectors of the daily position correction were compared to two collectives of patients, who were irradiated using the standard thermoplastic mask system (one cohort with head masks; one cohort with head and neck masks).

Results
The mean systematic errors in the experimental cohort ranged between 0.59 and 2.10 mm which is in a comparable range to the control groups (0.18 mm–0.68 mm and 0.34 mm–2.96 mm, respectively). The 3D-printed masks seem to be an alternative to the established thermoplastic mask systems. Nevertheless, further investigation will need to be performed.

Conclusion
The prevailing study showed a reliable and reproducible interfractional positioning accuracy using individually 3D-printed masks for whole brain irradiation in a clinical routine. Further investigations, especially concerning smaller target volumes or other areas of the body, need to be performed before using the system on a larger basis.
Real-time implementation of fast discriminative scale space tracking algorithm
Authors: Walid Walid , Awais Muhammad , Ahmed Ashfaq , Masera Guido , Martina Maurizio 
Published: May 2021

AbstractReal-time object tracking is an important step of many modern image processing applications. The efficient hardware design of real-time object tracker must achieve the desired accuracy while satisfying the frame rate requirements for a variety of image sizes. The existing methods of visual tracking employ sophisticated algorithms and challenge the capabilities of most embedded architectures. Discriminative scale space tracking is one algorithm that is capable of demonstrating good performance with affordable complexity. It has a high degree of parallelism which can be exploited for efficient implementation of reconfigurable hardware architectures. This paper proposes a real-time implementation of the discriminative scale-space tracker on FPGA for the major blocks. A careful design exploration of core mathematical operations of the tracking algorithm is performed to improve their hardware utilization and timing performance. Among the core functional units optimized in this work, the discrete Fourier transform achieves a computational time improvement of 92% relative to existing works, QR factorization achieves a 2.3$$\times$$
×
reduction in resource utilization, and singular value decomposition yields a 3.8$$\times$$
×
improvement in processing time. The proposed data path architecture is designed using Vivado HLS tool set and implemented for Zync Zed Board (xc7z020clg484-1). For an input image size of 320 $$\times$$
×
240, the proposed architecture achieves a mean 25.38 fps.
Imaging findings of granulocyte colony-stimulating factor-producing tumors: a case series and review of the literature
Authors: Kohno Shigeshi , Furuta Akihiro , Arizono Shigeki , Tokunaga Koji , Nakao Sei , Tanabe Masahiro , Kataoka Tatsuki R. , Isoda Hiroyoshi , Togashi Kaori 
Published: May 2021

AbstractGranulocyte colony-stimulating factor (G-CSF)-producing tumors have an aggressive clinical course. Here, we report five cases of G-CSF-producing tumors and review the literature, focusing on imaging findings related to tumor-produced G-CSF. In addition to our cases, we identified 30 previous reports of G-CSF-producing tumors on which 18F-fluorodeoxyglucose positron emission tomography (FDG-PET)/CT, bone scintigraphy, or evaluation of bone marrow MR findings was performed. White blood cell count, serum C-reactive protein, and serum interleukin-6 were elevated in all cases for which these parameters were measured. G-CSF-producing tumors presented large necrotic masses (mean diameter 83.2 mm, range 17–195 mm) with marked FDG uptake (mean maximum standardized uptake value: 20.09). Diffuse FDG uptake into the bone marrow was shown in 28 of the 31 cases in which FDG-PET/CT was performed. The signal intensity of bone marrow suggested marrow reconversion in all seven MRI-assessable cases. Bone scintigraphy demonstrated no significant uptake, except in two cases with bone metastases. Splenic FDG uptake was increased in 8 of 10 cases in which it was evaluated. These imaging findings may reflect the effects of tumor-produced G-CSF. The presence of G-CSF-producing tumors should be considered in patients with cancer who show these imaging findings and marked inflammatory features of unknown origin.
Fifteen Years After Sleeve Gastrectomy: Weight Loss, Remission of Associated Medical Problems, Quality of Life, and Conversions to Roux-en-Y Gastric Bypass—Long-Term Follow-Up in a Multicenter Study
Authors: Felsenreich Daniel M. , Artemiou Evi , Steinlechner Katharina , Vock Natalie , Jedamzik Julia , Eichelter Jakob , Gensthaler Lisa , Bichler Christoph , Sperker Christoph , Beckerhinn Philipp , Kristo Ivan , Langer Felix B. , Prager Gerhard 
Published: May 2021

Abstract
Purpose
Since 2014, sleeve gastrectomy (SG) has been the most frequently performed bariatric-metabolic operation worldwide (2018: 386,096). There are only a few studies reporting a long-term follow-up (up to 11 years) available today. The aim of this study was to evaluate the long-term outcome of SG with a follow-up of at least 15 years regarding weight loss, remission of associated medical problems (AMP), conversions, and quality of life (QOL).

Setting
Multicenter cross-sectional study; university hospital.

Methods
This study includes all patients who had SG before 2005 at the participating bariatric centers. History of weight, AMP, conversions, and QOL were evaluated by interview at our bariatric center.

Results
Fifty-three patients met the inclusion criteria of a minimal follow-up of 15 years. Weight and body mass index at the time of the SG were 136.8kg and 48.7kg/m2. Twenty-six patients (49.1%) were converted to Roux-en-Y gastric bypass (RYGB) for weight regain and gastroesophageal reflux within the follow-up period. Total weight loss after 15 years was 31.5% in the non-converted group and 32.9% in the converted group. Remission rates of AMP and QOL were stable over the follow-up period.

Conclusion
Fifteen years after SG, a stable postoperative weight was observed at the cost of a high conversion rate. Patients converted to RYGB were able to achieve further weight loss and preserve good remission rates of AMP. SG in patients without the need of a conversion to another bariatric-metabolic procedure may be considered effective. Careful preoperative patient selection is mandatory when performing SG.

Graphical abstract
Significance of Mast Cell Formed Extracellular Traps in Microbial Defense
Authors: Elieh Ali Komi Daniel , Kuebler Wolfgang M. 
Published: May 2021

AbstractMast cells (MCs) are critically involved in microbial defense by releasing antimicrobial peptides (such as cathelicidin LL-37 and defensins) and phagocytosis of microbes. In past years, it has become evident that in addition MCs may eliminate invading pathogens by ejection of web-like structures of DNA strands embedded with proteins known together as extracellular traps (ETs). Upon stimulation of resting MCs with various microorganisms, their products (including superantigens and toxins), or synthetic chemicals, MCs become activated and enter into a multistage process that includes disintegration of the nuclear membrane, release of chromatin into the cytoplasm, adhesion of cytoplasmic granules on the emerging DNA web, and ejection of the complex into the extracellular space. This so-called ETosis is often associated with cell death of the producing MC, and the type of stimulus potentially determines the ratio of surviving vs. killed MCs. Comparison of different microorganisms with specific elimination characteristics such as S pyogenes (eliminated by MCs only through extracellular mechanisms), S aureus (removed by phagocytosis), fungi, and parasites has revealed important aspects of MC extracellular trap (MCET) biology. Molecular studies identified that the formation of MCET depends on NADPH oxidase-generated reactive oxygen species (ROS). In this review, we summarize the present state-of-the-art on the biological relevance of MCETosis, and its underlying molecular and cellular mechanisms. We also provide an overview over the techniques used to study the structure and function of MCETs, including electron microscopy and fluorescence microscopy using specific monoclonal antibodies (mAbs) to detect MCET-associated proteins such as tryptase and histones, and cell-impermeant DNA dyes for labeling of extracellular DNA. Comparing the type and biofunction of further MCET decorating proteins with ETs produced by other immune cells may help provide a better insight into MCET biology in the pathogenesis of autoimmune and inflammatory disorders as well as microbial defense.
The relationship between social media use, anxiety and burden caused by coronavirus (COVID-19) in Spain
Authors: Brailovskaia Julia , Miragall Marta , Margraf Jürgen , Herrero Rocío , Baños Rosa M. 
Published: May 2021

AbstractThe outbreak of COVID-19 and national restrictions to slow down its spread have significantly changed people’s everyday lives. Many people engage in intensive social media use (SMU) to stay up-to-date about the pandemic. The present study investigated the extent of SMU as source of COVID-19 information, and its relationship with anxiety and the experienced burden caused by the pandemic in Spain. Of the 221 participants, 52.5% reported to frequently use SM as information source. The use of other information sources such as print and online newspaper reports, television reports, and official governmental online sites was not associated with anxiety and burden caused by the current COVID-19 situation. However, SMU was significantly positively linked to both variables. Moreover, anxiety significantly mediated the relationship between SMU and the experienced burden. The findings show the potential negative effect of SMU on individual emotional state and behavior during the pandemic. They emphasize the significance of an accurate and conscious use of SM specifically during extraordinary circumstances such as the COVID-19 outbreak.
Exploring the Functional Strategies Adopted by Coastal Plants Along an Ecological Gradient Using Morpho-functional Traits
Authors: Ciccarelli Daniela , Bona Cleusa 
Published: May 2021

AbstractCoastal dunes are characterised by strong interactions between biotic and abiotic factors along a short gradient from the shoreline to the inland region. We carried out an ecological analysis of the vegetation in a protected area of the Italian coast to evaluate the relationships among species abundance, the occurrence of morphoanatomical traits related to leaves, stems, and roots, and soil variables. Three transects were established perpendicular to the shoreline, with 27 plots distributed in the frontal dunes, backdunes, and temporarily wet dune slacks. An analysis based on community-weighted mean values showed that the pioneer communities of the frontal dunes were dominated by ruderals that are well adapted to the harsh ecological conditions of these environments, showing succulent leaves, high limb thickness values, and low values for leaf dry matter content (LDMC). The backdune vegetation was a mosaic of annual herbaceous and perennial shrub communities showing both ruderal and stress-tolerant strategies (clonality, sclerified leaves, high LDMC values, root phenolics) consistent with less extreme ecological conditions. The dune slack areas were dominated by plants showing adaptations to both arid and flooded environments, such as C4 photosynthesis, amphistomatic leaves, and abundant aerenchyma in the roots. The invasive status, C4 photosynthesis, leaf trichomes, and aerenchyma in the roots were significantly correlated with soil humidity, organic matter content, and pH. These results demonstrate the usefulness of anatomical traits (including root system traits) in understanding the functional strategies adopted by plants. Invasive species tended to occupy plots with high levels of soil moisture, suggesting an avoidance strategy for the harsh environmental conditions of coastal sand dunes. Finally, we suggest including information regarding root systems into coastal monitoring programs because they are directly linked to soil parameters useful in coastal dune management and protection.