bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outdoor sunscreen testing with high‐intensity solar exposure in a Chinese and Caucasian population
Authors: Granger Corinne , Ong Gavin , Andres Philippe , Trullàs Carles , Hosenally Muzzammil , Lai Wei , Liu Wei , Krutmann Jean , Passeron Thierry , Lim Henry W. 
Published: June 2021

AbstractBackgroundCurrently, sunscreens' sun protection factor (SPF) and ultraviolet (UV) A protection are tested separately under indoor conditions, without considering external conditions that may affect performance. Studies are often conducted in Caucasian individuals; other racial groups may respond differently.MethodsAn outdoor, double‐blind, intra‐individual study was performed in 63 healthy Chinese and Caucasian volunteers in Singapore. Subjects underwent one outdoor sun exposure lasting 2‐3 hours. ISO reference products P3 (SPF 15), P5 (SPF 30), and P8 (SPF 50+) applied at 2 mg/cm2 were compared against each other and against an untreated exposed area (positive control) and an unexposed area (negative control). Endpoints were investigator global assessment (IGA) of erythema at 24 hours, IGA of pigmentation at 1 week, and colorimetry (a*, L*, and ITA) at 24 hours and 1 week.ResultsClinical erythema and pigmentation scores were statistically significantly different among the three sunscreens, with the highest SPF product providing the highest protection, confirming the discriminatory capacity of the model used. Colorimetric assessment correlated well with clinical evaluation.ConclusionThis study confirmed the feasibility of ranking sunscreens (at 2 mg/cm2) based on clinical effects of high‐intensity outdoor solar radiation. Larger studies are needed to look at differences in erythema and pigmentation reactions between Chinese and Caucasian individuals, which could be relevant for photoprotection.
Outcomes of repeat kidney transplantation following prior graft failure secondary to BK nephropathy: A single‐center retrospective study
Authors: Dong Rachel , Shetty Aneesha , Tambur Anat R , Ison Michael G. 
Published: June 2021

AbstractBackgroundBK virus is associated with development of nephropathy (BKVN) that can lead to graft failure after renal transplantation. There are limited data on rates of recurrence and outcomes of repeat renal transplantation after prior graft loss caused by BKVN.MethodsAfter IRB approval, data on all patients who underwent a repeat renal transplantation after prior graft failure as a result of BKVN were identified. Data on management of patients prior to retransplantation, induction and maintenance immunosuppression, and key clinical and virologic outcomes were collected. Descriptive statistics were used for analysis.ResultsThirteen patients were identified over a 13‐year period, and follow‐up of these patients occurred for a median of 4.7 years. Most patients have previous renal transplants removed prior to (7/13, 53.8%) or at the time of retransplantation (3/13, 23.1%). Close virologic monitoring of serum and urine, coupled with early immunosuppression minimization, was associated with few patients developing BK viruria above 1 × 107 c/mL (4/13, 30.8%), BK viremia above 10,000 c/mL (2/13, 15.4%), and biopsy‐proven BKVN (1/12, 8.3%); most (8/13, 61.5%) developed BK viruria at any level. Renal function at 1 year post‐retransplantation was generally excellent and only 1 patient developed graft failure caused by recurrent focal segmental glomerulosclerosis. In our review of the literature, 2 large observational studies of the UNOS database as well as our analysis of case reports showed excellent graft survival and very low rates of recurrent BKVN leading to graft loss.ConclusionsRetransplantation after prior graft failure caused by BKVN generally has low rates of recurrence when coupled with close monitoring and early immunosuppression minimization. Removal of failed renal transplant may allow easier monitoring for recurrence.
Ferredoxin 1 is downregulated by the accumulation of abscisic acid in an ABI5‐dependent manner to facilitate rice stripe virus infection in Nicotiana benthamiana and rice
Authors: Cui Weijun , Wang Shu , Han Kelei , Zheng Ersong , Ji Mengfei , Chen Binghua , Wang Xuming , Chen Jianping , Yan Fei 
Published: June 2021

SummaryFerredoxin 1 (FD1) accepts and distributes electrons in the electron transfer chain of plants. Its expression is universally downregulated by viruses and its roles in plant immunity have been brought into focus over the past decade. However, the mechanism by which viruses regulate FD1 remains to be defined. In a previous report, we found that the expression of Nicotiana benthamiana FD1 (NbFD1) was downregulated following infection with potato virus X (PVX) and that NbFD1 regulates callose deposition at plasmodesmata to play a role in defense against PVX infection. We now report that NbFD1 is downregulated by rice stripe virus (RSV) infection and that silencing of NbFD1 also facilitates RSV infection, while viral infection was inhibited in a transgenic line overexpressing NbFD1, indicating that NbFD1 also functions in defense against RSV infection. Next, a RSV‐derived small interfering RNA was identified that contributes to the downregulation of FD1 transcripts. Further analysis showed that the abscisic acid (ABA) which accumulates in RSV‐infected plants also represses NbFD1 transcription. It does this by stimulating expression of ABA insensitive 5 (ABI5), which binds the ABA response element motifs in the NbFD1 promoter, resulting in negative regulation. Regulation of FD1 by ABA was also confirmed in RSV‐infected plants of the natural host rice. The results therefore suggest a mechanism by which virus regulates chloroplast‐related genes to suppress their defense roles.
CALLUS FORMATION AND PLANT REGENERATION FROM IMMATURE EMBRYOS OF PIGMENTED UPLAND RICE (Oryza sativa cv. Tadong)
Authors: Yan Hoo Kah , Chin Lee Ping , Latip Mariam A. , Surugau Noumie , A. Aziz Zaleha 
Published: June 2021

The application of biotechnology in upland rice improvement programs depends on the availability of efficient regeneration protocols. Although protocols for shoot regeneration of upland rice are available, none has been reported for pigmented cultivars. This study reports on a protocol for callus induction and regeneration of Tadong, a pigmented upland rice cultivar from Sabah. For callus induction, immature embryos were cultured on media containing 2,4-Dichlorophenoxyacetic (2,4-D) at various concentrations (0 – 2.5 mg/L) and on different types of media (MS; MSB5; N6B5; N6). To induce shoot regeneration, callus explants were cultured on MS medium supplemented with combinations of 6-Benzylaminopurine (BAP) at various concentrations (0 – 3.0 mg/L) and 1-Naphthaleneacetic acid (NAA) at 1.0 mg/L. To induce shoot development, callus explants were pre-treated with Thidiazuron (TDZ) at various concentrations (0-1.0 mg/l) and exposed to different desiccation periods (0 – 72 hours). 2,4-Dichlorophenoxyacetic at 2.5 mg/L and N6B5 medium resulted in the highest percentages of explant forming callus which were 60.3 ± 17.0 % and 58.7 ± 9.8 % respectively. The regeneration media failed to induce shoot on callus explants, instead, green spots were formed on the surface of the callus. The green spots were stimulated to develop into shoots when the callus explants were pre-treated with 0.5 mg/L TDZ or exposed to partial desiccation for 24 h, the percentages of explant forming shoot were 35.7 ± 4.8 % and 47.7 ± 6.8 % respectively. Shoots developed into complete plants on hormone-free MS medium and acclimatized.
FMRP y las neuroliginas: la influencia de la actividad sensorial en las dinámicas del neurodesarrollo
Authors: Viveros Araque Elisa , Rengifo Gomez Juliana , Becerra-Hernández Lina Vanessa 
Published: June 2021

El síndrome de Frágil X (SFX) es la principal causa hereditaria de discapacidad cognitiva y la causa hereditaria conocida más común en los Trastornos del Espectro Autista (TEAs). En este síndrome se afecta la expresión de la proteína de retardo mental del cromosoma X frágil (FMRP), una proteína reguladora de la traducción de ARN. FMRP participa en el refinamiento de los circuitos neuronales durante el desarrollo. Las fallas en su función coinciden con la aparición de circuitos neuronales sobreabundantes en espinas dendríticas inmaduras y con pérdida de la plasticidad sináptica.
Por otra parte, las neuroliginas (Nlgs), que se han encontrado mutadas en algunos pacientes con TEAs, son proteínas de adhesión neuronal postsináptica. Estas proteínas ayudan a la especialización y la maduración dendrítica, y su mutación coincide con alteraciones en la transmisión sináptica.
Dado que FMRP y Nlgs son proteínas necesarias para los procesos de eliminación y maduración sináptica afectados tanto en FXS como en TEAs, en esta revisión recopilamos y examinamos la evidencia de los principales hallazgos sobre estas proteínas, su relación y su modulación dependiente de la actividad generada por la experiencia sensorial. Además, destacamos a Drosophila melanogaster como el organismo de las emergentes investigaciones en este campo.
“TE ACOMPAÑAMOS": enseñando profesionalismo en un centro colombiano de atención ambulatoria
Authors: Robayo Gonzalez Claudia Ximena , Páez Rojas Paola Liliana , Falla Rivas Ruth Asceneth , Ayala Copete Ana Maria , Villanueva Congote Juliana 
Published: June 2021

Introducción: La necesidad de un aprendizaje integral que trascienda el conocimiento teórico es fundamental en el proceso de formación del estudiante de medicina. Por lo anterior surge “Te acompañamos” como una estrategia de aprendizaje experiencial que busca potenciar el desarrollo de humanización y profesionalismo médico mediante un programa basado en el acompañamiento de adultos mayores por parte de estudiante de medicina en un centro de atención primaria.
Métodos: El programa inició en 2017 en la ciudad de Bogotá con una recolección de datos y análisis hasta 2019. Se valoró la experiencia del estudiante mediante una encuesta semiestructurada de preguntas abiertas basada en la codificación de los calificativos descritos en las vivencias. Se evaluó la experiencia del paciente mediante una encuesta estructurada telefónica que arrojó indicadores porcentuales de satisfacción.
Resultados: 289 estudiantes participaron beneficiando a 824 adultos mayores. Se resalta el desarrollo de comportamientos prosociales, empatía y conocimiento del contexto del paciente al finalizar la experiencia. Además, se destaca la satisfacción por encima del 90% de los beneficiarios y la humanización de la atención recibida en el centro.
Conclusión: La humanización y profesionalismo es necesario en la formación integral médica. Por esto, se necesita articular estrategias de enseñanza vivencial en la práctica clínica para lograr mejores resultados.
Síndrome de infusión por propofol: revisión de tema
Authors: Tabares Arboleda Maria Paz , Ávila Lina María , Londoño Duarte María Piedad 
Published: June 2021

El Propofol es un agente anestésico endovenoso usado ampliamente en la inducción y mantenimiento de anestesia, así como en sedación de pacientes en diferentes escenarios. Sus propiedades farmacocinéticas y farmacodinámicas hacen de este un medicamento ideal para el cuidado de pacientes críticos. Algunas de ellas, su rápido inicio de acción y recuperación tras suspender la infusión, además de la presencia de pocos efectos adversos, lo hacen favorable en ciertas condiciones clínicas (descenso de la Presión Intracraneana [PIC] en pacientes con Trauma Cráneo Encefálico [TCE]). Sin embargo, desde hace más de 20 años se han reportado casos en la literatura con respecto a la presencia de signos y síntomas comunes relacionados con la infusión de propofol a dosis mayores de 4 – 5mg/kg/h y por largos periodos de tiempo (>48hrs), como acidosis metabólica, disfunción cardiaca y renal, rabdomiolisis, hipertrigliceridemia e hipercalemia, que en conjunto son conocidos como Síndrome de Infusión de Propofol (SIP). Si bien esta patología es poco frecuente, es potencialmente fatal sin un diagnóstico y tratamiento oportuno. El presente artículo pretende dejar unos puntos claros sobre su fisiopatología, características clínicas, diagnóstico y tratamiento con base en la literatura actual.
Trombosis aguda idiopática no puerperal de la vena ovárica: presentaciónde caso y revisión de la literatura
Authors: Inga Ceballos Dayana Alejandra , Montaña Manrique David Enrique , Quevedo Florez Leonardo Alexander , Matiz Espinoza Raul Esteban 
Published: June 2021

La trombosis de la vena gonadal es una enfermedad poco frecuente, asociada a estados de hipercoagulabilidad. Se presenta principalmente en el período postparto, o en menor frecuencia en otras condiciones gineco obstétricas como cesáreas, abortos, neoplasias ginecológicas y en enfermedad pélvica inflamatoria (EPI). Este documento es una revisión de casos de la literatura asociada a un reporte de un caso con presentación no habitual de esta entidad que nos lleva a recordar esta condición como diagnóstico diferencial en dolor abdominopélvico agudo, así como su enfoque diagnóstico y tratamiento en el departamento de emergencias.
Linking cohort-based data with electronic health records: a proof-of-concept methodological study in Hong Kong
Authors: Gao Le , Leung Miriam T Y , Li Xue , Chui Celine S L , Wong Rosa S M , Au Yeung Shiu Lun , Chan Edward W W , Chan Adrienne Y L , Chan Esther W , Wong Wilfred H S , Lee Tatia M C , Rao Nirmala , Wing Yun Kwok , Lum Terry Y S , Leung Gabriel M , Ip Patrick , Wong Ian C K 
Published: June 2021

ObjectivesData linkage of cohort-based data and electronic health records (EHRs) has been practised in many countries, but in Hong Kong there is still a lack of such research. To expand the use of multisource data, we aimed to identify a feasible way of linking two cohorts with EHRs in Hong Kong.MethodsParticipants in the ‘Children of 1997’ birth cohort and the Chinese Early Development Instrument (CEDI) cohort were separated into several batches. The Hong Kong Identity Card Numbers (HKIDs) of each batch were then uploaded to the Hong Kong Clinical Data Analysis and Reporting System (CDARS) to retrieve EHRs. Within the same batch, each participant has a unique combination of date of birth and sex which can then be used for exact matching, as no HKID will be returned from CDARS. Raw data collected for the two cohorts were checked for the mismatched cases. After the matching, we conducted a simple descriptive analysis of attention deficit hyperactivity disorder (ADHD) information collected in the CEDI cohort via the Strengths and Weaknesses of ADHD Symptoms and Normal Behaviour Scale (SWAN) and EHRs.ResultsIn total, 3473 and 910 HKIDs in the birth cohort and CEDI cohort were separated into 44 and 5 batches, respectively, and then submitted to the CDARS, with 100% and 97% being valid HKIDs respectively. The match rates were confirmed to be 100% and 99.75% after checking the cohort data. From our illustration using the ADHD information in the CEDI cohort, 36 (4.47%) individuals had ADHD–Combined score over the clinical cut-off in the SWAN survey, and 68 (8.31%) individuals had ADHD records in EHRs.ConclusionsUsing date of birth and sex as identifiable variables, we were able to link the cohort data and EHRs with high match rates. This method will assist in the generation of databases for future multidisciplinary research using both cohort data and EHRs.
Knowing the goal: an inclusive economy that can address the public health challenges of our time
Authors: Shipton Deborah , Sarica Shifa , Craig Neil , McCartney Gerry , Katikireddi Srinivasa Vittal , Roy Graeme , McGregor Peter , Scobie Graeme 
Published: June 2021

ObjectiveInequality is deeply embedded in our economic structures—it is necessary to address these economic inequalities if we are to reduce health inequalities. An inclusive economic approach was conceptualised as a way to reduce these economic inequalities, although the attributes of this approach are unclear. Public health practitioners are increasingly asked to provide a health perspective on the economic recovery plans in the light of the COVID-19 pandemic. This paper aims to identify the attributes of an inclusive economy to enable the public health profession to influence an inclusive economic recovery.ApproachWe conducted a rapid review of grey and peer-reviewed literature to identify the attributes of an inclusive economy as currently defined in the literature.Attributes of an inclusive economyTwenty-two concepts were identified from 56 reports and articles. These were collapsed into four distinct attributes of an inclusive economy: (1) an economy that is designed to deliver inclusion and equity, (2) equitable distribution of the benefits from the economy (eg, assets, power, value), (3) equitable access to the resources needed to participate in the economy (eg, health, education), and (4) the economy operates within planetary boundaries.ConclusionAs economies are (re)built following the COVID-19 pandemic, these attributes of an inclusive economy—based on the current literature—can be used to develop, and then monitor progress of, economic policy that will reduce health inequalities, improve health and mitigate against climate change.
Introduction to Comparative Theology in Australia and Asia
Authors: Clooney Francis X. 
Published: June 2021

Abstract
Comparative theology is a form of theology, and as such, a matter of “faith seeking understanding.” Like other forms of Christian theology, it is indebted to scripture and tradition, attentive to texts, and also to images, ritual practice, piety, and experience. Like other forms of theological reflection, it also needs to be contextually nuanced, lest it be too much identified with the North American and Western European academic contexts. The growth of comparative theology in Asia and Australia over the last decade is one of the most exciting developments in the field. These essays, the majority of which were given at an international conference at the Australian Catholic University in July 2019, signal the ways in which comparative theology benefits from its clarification and adaptation in Australia, China, India, Indonesia, Japan, Singapore, and South Korea.
The Early Buddho-Daoist Encounter as Interreligious Learning in the Chinese Context
Authors: Yu Fu 
Published: June 2021

Abstract
This paper contends that the methodological tool of comparative theology, arising from and developing in Euro-American academia, resonates strongly with the historical interreligious learning praxis of China. Attention to comparative theology may indeed help us rethink the formation of a Chinese cultural identity vis-à-vis its religious others. A malleable way of doing comparative theology may offer nothing less than the mutual transformation of the interreligious interlocutors in a way consonant with Chinese history.
A historical review of the interaction between Chinese Buddhism and Daoism shows that the adoption of Daoist terminology and concepts facilitated the Buddhist entry into the local milieu, while medieval Chinese Buddhism became paradigmatic for the elaboration of Daoist doctrine. The Buddho-Daoist interaction coheres with the enterprise of comparative theology with respect to the nature of interaction between religious traditions, the appropriative yet distinctive religious self-identification, and the transformation of the self and the other.
Salvation Through Saving Others
Authors: Sawai Makoto 
Published: June 2021

Abstract
Every year various disasters such as earthquakes, typhoons, and floods hit Japan. In the Great East Japan Earthquake of 2011, approximately 16,000 people lost their lives due to the tsunami and the consequent collapse of buildings. Voluntary groups and religious institutions came to affected areas from every part of Japan to help the recovery of those struck by disasters. Drawing on the idea of “path” that is so prominent in Asia, including in Japan, Tenrikyo and Islam teach their adherents the importance of voluntary activities such as hinokishin in Tenrikyo and ṣadaqah in Islam, as the sure path to salvation. Various motivations are found in the activities and reverential attitudes to God by the adherents in both religious traditions. In this paper, by paying attention to the relationship between religious doctrines and voluntary activities in Tenrikyo and Islam, I try to compare the characteristics of both from the viewpoint of “salvation,” according to the practice of comparative theology.
Becoming a Christian and Practicing Comparative Theology for a Korean Theologian
Authors: Lee Yongho Francis 
Published: June 2021

Abstract
Koreans live in a religiously pluralistic and tolerant society, and the idea of an exclusive membership of one religion is still foreign to many. In the first part of this paper, I will explore the development of the concept of “religion” and “religious belonging” or “religious identity” in the West, and its imposition on Asian people. Then I will reflect on the establishment of my own religious identity, that is, becoming a Christian in a religiously pluralistic society. In the second part, I will discuss further how my studying comparative theology as an Asian convert to Christianity is distinguished from the work of western Christian comparative theologians.
The sequence of heavy precipitation and flash flooding of 12 and 13 September 2019 in eastern Spain. Part II: A hydro-meteorological predictability analysis based on convection-permitting ensemble strategies
Authors: Amengual A. , Hermoso A. , Carrió D. S. , Homar V. 
Published: June 2021

AbstractOn 12 and 13 September 2019, widespread flash flooding caused devastating effects across eastern Spain. Within the framework of the HyMeX program, this study examines predictability of the long-lasting heavy precipitation episode (HPE) conducive to flash flooding. A set of short-range, convection-permitting ensemble prediction systems (EPSs) is built to cope with different sources of meteorological uncertainty. Specifically, the performance of an Ensemble Kalman Filter, tailored bred vectors and stochastic model parameterizations is compared to more standard ensemble generation techniques such as dynamical downscaling and multiple physics. Results indicate EPS focusing on sampling model uncertainties related to parameterization of subgrid process are skillful, especially when deep convection and its interaction with complex orography are important. Furthermore, representation of small-scale thermodynamical aspects is improved through data assimilation, leading to an enhanced forecasting skill as well. Nevertheless, predictability remains relatively low at the catchment scale in terms of exceedance probabilities in cumulative precipitation and peak discharge. The analysis presented herein could serve as a basis for the future implementation of real-time flash flood warning systems based on skillful meteorological EPSs over small-to-medium, semi-arid watersheds in eastern Spain and, by extension, over the flood-prone Western Mediterranean region.