bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring and Evaluation of Antibiotic Resistance Genes in Three Rivers in Northeast China
Authors: Zhao Chen , Li Chenyu , Wang Xiaoming , Cao Zhuosong , Gao Chao , Su Sicong , Xue Bin , Wang Shang , Qiu Zhigang , Wang Jingfeng , Shen Zhiqiang 
Published: October 2021

Abstract
Background: Antibiotic resistance genes (ARGs) have become an important public health problem. In this study, we used metagenomic sequencing to analyze the composition of ARGs in certain original habitats of northeast China, comprising three different rivers and riverbank soils of the Heilongjiang River, Tumen River, and Yalu River. Results: Twenty types of ARG were detected in every water sample. The major ARGs were multidrug resistance genes, at approximately 0.5 copies/16s rRNA, accounting for 57.5% of the total ARG abundance. The abundance of multidrug, bacitracin, beta-lactam, macrolide‑lincosamide‑streptogramin, sulfonamide, fosmidomycin, and polymyxin resistance genes covered 96.9% of the total ARG abundance. No significant ecological boundary of ARG diversity was observed. The compositions of the resistance genes in the three rivers were very similar to each other, and 92.1% of ARG subtypes were shared by all water samples. Except for vancomycin resistance genes, almost all ARGs in riverbank soils were detected in the river water. About 31.05% ARGs were carried by Pseudomonas. Opportunistic pathogenic bacteria carrying resistance genes were mainly related to diarrhea and respiratory infections. Multidrug and beta-lactam resistance genes correlated positively with mobile genetic elements (MGEs), indicating a potential risk of diffusion.Conclusions: The composition of ARGs in three different rivers was similar, indicating that climate played an important role in ARG occurrence. ARG subtypes in river water were almost completely the same as those in riverbank soil. ARGs had no significant geographical distribution characteristics. Many ARGs were carried by human pathogenic bacteria related to human diarrhea and respiratory infections, such as Pseudomonas aeruginosa and Aeromonas caviae. In general, our results provide a valuable dataset of river water ARG distribution in northeast China. The related ecological geography distribution characteristics should be further explored.
Effect of Flaxseed and Flaxseed Oil Supplemented in Caiman Diet on Meat Fatty Acids
Authors: Leiva Pamela M. de L. , Frutos Antonio E. , Lavandera Jimena , Simoncini Melina Soledad , Labaque María C. , Piña Carlos I. 
Published: October 2021

Abstract
Increasing polyunsaturated or long-chain fatty acids in meat for human consumption improves both nutritional quality and consumer perception. The increase could occur through the addition of rich sources of omega-3 fatty acids (such as flaxseed or flaxseed oil) to the animal diet. The aim of this study was to evaluate the effects of dietary supplement with two presentations of flax (crushed seeds or oil) on the change of FA content in two cuts of caiman meat (tail and neck). We measured fatty profile in two different caiman meat cuts (neck and tail) from 30 animals (total length 96.7 ± 4.9 cm, snout-vent length 47.8 ± 3 cm, weight 4.2 ± 0.6 kg), raised in individual enclosures, fed three a week for 50 days with: crushed chicken head and a dry food formulated for these reptiles in a 70/30 ratio (C, n=10), control diet with 10% crushed flaxseed (FS, n=10), and control diet with 10% flaxseed oil (FO, n=10), while the remaining days animals were fed the control diet. Meats from animals fed both enrichment diet (FS and FO) showed an increase of C18:3n-3 and ΣUFA respect to control diet. Although both enriched diets raised the levels of C18:3n-3, the neck showed higher values than the tail. We observed that the neck, is more susceptible that the tail to be improved by FO, which could suggest that it is more beneficial to consume neck meat. In order to be implemented in caiman farms, flaxseed oil is more expensive than seed, but more effective, easier to manage and is practical for application on caiman farms.
Spatio-temporal Characteristics of Tuberculosis in Ghana
Authors: Iddrisu Abdul-Karim , Amikiya Emmanuel A. , Bukari Francis Kwame 
Published: October 2021

Abstract
Background: Recent global reports show that the number of Tuberculosis (TB) cases or deaths is declining, however, the rate of decline is not adequate to meet the World Health Organization's (WHO's) mitigation. TB remains a public health problem in Ghana with a significant economic and health burden on citizens and health infrastructure. Aims: Consequently, there is a need for further studies about the disease aimed at accelerating the rate of decline in cases. Methods: In this article, we study the spatio-temporal characteristics of TB in Ghana, using data obtained from Ghana National Tuberculosis Programme (NTP) for the 10 regions of Ghana, collected over a six-year period. Bayesian spatial and space-time regression models are used to map the risk of TB infections across the nation, in time and space. The study also examines some baseline predictors of TB infections to ascertain their effects on the TB risk. Results: Our study results showed that hot-spots of TB cases are observed in the Upper East, Upper West, Volta, Western, and Central regions and low risk in the Northern, Ashanti, Greater Accra, Brong Ahafo, Eastern and Western regions. We observed clustering of risk between neighboring regions. TB cure rate, TB success rate, knowledge about TB, awareness that TB is airborne, HIV prevalence, percentage of literacy, high income are important predictors of TB detection across the 10 regions of Ghana. Conclusions: Most regions in Ghana have similar TB risk. Efforts for more TB cases detection should be encouraged to increase TB success and cure rate which will lead to substantial decrease in TB spread. There is the need for provision of adequate health facilities with easy access to these facilities irrespective of your income status to bridge the gap between TB cases among the poor and the rich. TB cases are expected to grow exponentially in countries with low success and cure rate. Finally, for a substantial TB cases reduction, there is the need to adopt measures that will increase TB cases detection, TB success and cure rates, TB awareness, knowledge about how TB spread as well adequate health facilities with easy access.
The Average Environmental Efficiency Technique and its Application to Chinese Provincial Panel Data
Authors: Tang Jing , Yang Feng , Wei Fangqing 
Published: October 2021

Abstract
In this study, we propose average environmental efficiency, a consistent and robust environmental efficiency measurement, and use it to evaluate the environmental efficiency of Chinese provinces. With the help of a nonparametric directional distance function approach, we can measure all possible environmental efficiency scores of the province by considering all projection directions to the efficient frontier. Then, the mean value of the environmental efficiency scores of a province in all possible projection directions is defined as the average environmental efficiency. Furthermore, we investigate the influencing factors of regional environmental efficiency via a feasible generalized least squares regression approach. The empirical results show that China’s national environmental efficiency has a high value of 0.803, and only nine provinces have average environmental efficiency greater than the average of the country. This implies that two-thirds of provinces still have much room for improvement. In addition, the east area achieved the best average environmental efficiency over the studied period, followed in order by the west area, central area, and northeast area. Moreover, we find that the energy consumption structure, government intervention, and economic openness negatively influence the regional environmental efficiency, while higher education positively influences this efficiency at the 1% significance level.
Estimating the Effect of Climate Internal Variability and Source of Uncertainty in Climate-Hydrological Projections in a Representative Watershed of Northeastern China
Authors: Cai Wenjun , Zhu Xueping , Zhao Xuehua , Zhang Yongbo 
Published: October 2021

Abstract
The decomposition and quantification of uncertainty sources in ensembles of climate-hydrological simulation chains is a key issue in climate impact researches. The mainly objectives of this study partitioning climate internal variability (CIV) and uncertainty sources in the climate-hydrological projections simulation process, the climate simulation process formed by six downscaled GCMs under two emission scenarios called GCMs-ES simulation chain, the hydrological simulation process add one calibrate Soil and Water Assessment Tool (SWAT) model called GCMs-ES-HM simulation chain. The CIV and external forcing of climate projections are investigated in each GCMs-ES simulation chain. The CIV of precipitation and ET are large in rainy season, and the single-to-noise ratio (SNR) are also relatively high in rainy season. Furthermore, the uncertainty decomposed frameworks based on analysis of variance (ANOVA) are established. The CIV and GCMs are the dominate contributors of runoff in rainy season. It worth noting the CIV can propagate from precipitation and ET to runoff projections. In additional, the hydrological model parameters are the third uncertainty contributor of runoff, which embody the hydrological model simulate process play important role in hydrological projections in future. The findings of this study advised that the uncertainty is complex in hydrological, hence, it is meaning and necessary to estimate the uncertainty in climate simulation process, the uncertainty analysis results can provide effectively efforts to reduce uncertainty and then give some positive suggestions to stakeholders for adaption countermeasure under climate change.
Comparative analysis of restoration behavior of milo (104A, 401A) and maldandi (M31-2A) based male sterile lines in sorghum [Sorghum bicolor (L.) Monech]
Authors: Verma Lokesh Kumar Verma Kumar , Biradar B. D. , Patil S. S. , Chattannavar S. N. , Kubsad V. S. 
Published: October 2021

Abstract
In sorghum, milo source of male sterility has been used for developing all the hybrids so far and it created the narrow cytoplasmic base. In addition, it also narrows down the nuclear diversity which may be the invitation for the outbreak of pests and diseases in the near future. To handle this hazard new diverse sources like A2, A3, A4, maldandi, VZM and G1 have been discovered. The availability of restorers on these sources is very difficult hence their utilization is also a challenging task. The present study was, therefore, carried out to test different sorghum lines for restoration behavior on two milo lines (104A and 401A) and one maldandi (M31-2A) with more emphasis on maldnadi source because of its added advantage of enhancing grain size and pest tolerance. In rabi-2017, 125 genotypes were tested for the restoration behavior on these sources, and five restorers viz., IS 19389, IS 995, IS 28389, IS 26046 (BRJ 67 − 8) and DSMR-8 restored fertility on 104A, two lines viz., IS 29335 and IS 26046 restored on 401A, while on M31-2A six lines viz., IS 19975, BRJ-67-4 (DSMR-4), BRJ 67 − 8 (DSMR-8), BRJ 67 − 16, BRJ 67 − 19, BRJ 67 − 21 restored the fertility. only two lines DSMR-8 and DSMR-4 exhibited stable, consistent and strong restoration (> 90% seed set) across the seasons (rabi-2017 and kharif-2017) and years (2017 and rabi-2018). All the used MS lines exhibited the restoration complexity in the following order − 104A < 401A < M31-2A.
Spatiotemporal Variation of Blue And Green Water And Its Impact On Water Supply Under Future Climate Change
Authors: Li Fawen , Meng Fanjin , Luo Qingyang , Liu Yaoze 
Published: October 2021

Abstract
In order to improve the effective utilization of water resources, it is necessary to carry out prediction research on the response of water resources to climate change in the future. Based on the measured meteorological data, daily precipitation and temperature data after downscaling, the SWAT model was used to simulate the spatiotemporal distribution characteristics of blue and green water resources in the base period and the next three periods, and to analyze the impact of blue water change on the combined water supply of Ganhuang Reservoir under future climate. The results showed that: In the future, the average annual precipitation in Ganghuang Reservoirs will vary from -18% to -6%, and the maximum and minimum temperature will increase by 2.12℃ and 1.66℃, respectively. Compared with the base period, the blue water resources under the two RCP concentration paths will decrease by 8%~18%, while the green water resources will increase by 5%~14%. The distribution of blue and green water resources shows significant spatial differences. Under future climate scenario, the water input from Gangnan Reservoir to Huangbizhuang Reservoir will be reduced by about 45 million m3, and the water supply risks under the two climate scenarios are 0.49 and 0.29, respectively.
Antimicrobial Action of Arylsulfonamides Bearing (aza)Norbornane and Related Motifs: Evaluation of New Promising Anti-MRSA Agents
Authors: Palchykov Vitalii , Manko Nazar , Finiuk Nataliya , Stoika Rostyslav , Obushak Mykola , Pokhodylo Nazariy 
Published: October 2021

Abstract
Arylsulfonamides bearing (aza)norbornane and related motifs were evaluated for: 1) antimicrobial activity toward five key ESKAPE pathogenic bacteria, one Gram‐positive bacteria methicillin‐resistant Staphylococcus aureus (MRSA, ATCC 43300), four Gram‐negative bacteria, Escherichia coli (ATCC 25922), Klebsiella pneumonia (ATCC 700603), Acinetobacter baumannii (ATCC 19606), and Pseudomonas aeruginosa (ATCC 27853), and 2) antifungal activity toward two pathogenic fungal strains - Candida albicans (ATCC 90028) and Cryptococcus neoformans var. Grubii (H99; ATCC 208821). Four compounds with 4-nitrobenzenesulfonamide motif (VP-4556, VP-4604, VP-4605, and VP-4509) demonstrated high toxicity toward methicillin‐resistant Staphylococcus aureus (ATCC 43300). These compounds also possessed high antibacterial activity toward gram-negative bacteria P. aeruginosa (ATCC9027). According to the results of toxicity studies of the compounds to HEK-293, HaCaT, Balb/c 3T3, red blood cells and normal mitogen-activated lymphocytes, three compounds - VP-4556, VP-4604 and VP-4509 - bearing azanorbornene, octahydro-3,5-methanocyclopenta[b]pyrrole and bio-isosteric piperidine motifs were selected for further studies as biocompatible agents with promising antimicrobial activity.
Exploratory Study on Constructing an Evaluation Index System of Value-based Healthcare Delivery in China
Authors: Wang Canghong , Zhu Liang , cheng Wenwen , Wang Rui 
Published: October 2021

Abstract
Background

The current healthcare model is challenged by fewer concerns with healthcare quality and its sustainable development, affecting all participants involved in the healthcare system.Value-based healthcare (VBHC) delivery refers to a new management paradigm that prioritizes patients’ health outcomes at lower healthcare costs.The use of value payments can effectively control the increases in medical costs and reduces the cost of health systems, presenting pieces of evidence in improving the diagnosis and treatment results as well as creating value for patients. Extant studies have investigated VBHC preparation and formulated a set of evaluation indices in the West context. However, a dearth of VBHC-related research conducted in China was noted wherein the VBHC’s evaluation system has not yet been explored. Thus, this study aims at developing China’s medical service attitude appraisal evaluation framework by adopting VBHC delivery.
Results

Two rounds of surveys found the authority degree coefficient of experts (0.805 and 0.812), degree of positivity (93.75% and 100%), the range of arithmetic means for the importance (3.30–5.0 and 4.05–5.0), the range of full-score frequency (16–94% and 23–100%), the range of variable coefficient (0.11–0.29 and 0.0–0.12), and the coordination coefficient (0.39 and 0.79; p༜0.5 for all). The final evaluation index system comprises 35 items with three, nine, and 23 first-, second-, and third-level indicators, respectively. The three first-level indicators and their weight coefficients are data collection and sharing of treatment cost and curative effect for specific diseases (0.409), medical expense payers (0.245), and healthcare providers (0.346).
Conclusions

This study constructs an evaluation index system on the basis of the VBHC delivery, the study methods are reasonable, the experts representativeness are high, the positivity degree and authority degree of experts are high, the concentration degree and coordination degree of experts’ opinions are good, and the weight of the indicators was calculated, which is scientific and can be used as a tool to evaluate the implementation of the VBHC delivery in China.
On the Relationship between Mind Wandering and Mindfulness
Authors: Belardi Angelo , Chaieb Leila , Rey-Mermet Alodie , Mormann Florian , Rothen Nicolas , Fell Juergen , Reber Thomas P. 
Published: October 2021

Abstract
Mind wandering (MW) and mindfulness have both been reported to be vital moderators of psychological wellbeing. Here, we aim to examine how closely associated these phenomena are and evaluate the psychometrics of measures often used to quantify them. We investigated two samples, one consisting of German-speaking unpaid participants (GUP, n=313) and one of English-speaking paid participants (EPP, n=228) recruited through MTurk.com. In an online experiment, we collected data using the Mindful Attention Awareness Scale (MAAS) and the Sustained Attention to Response Task (SART) during which self-reports of MW and meta-awareness of MW were recorded using experience sampling (ES) probes. Internal consistency of the MAAS was high (Cronbachs α of 0.96 in EPP and 0.88 in GUP). Split-half reliability for SART measures and self-reported MW was overall good with the exception of SART measures focusing on Nogo trials, and those restricted to SART trials preceding ES in a ten-second time window. We found a moderate negative association between trait mindfulness and MW as measured with ES probes in GUP, but not in EPP. Our results suggest that MW and mindfulness are on opposite sides of a spectrum of how attention is focused on the present moment and the task at hand.
Influence of Financial Burden on Withdrawal or Change of Cancer Treatment in Japan: Results of a Bereavement Survey
Authors: Sasaki Taichi , Aoyama Maho , Igarashi Naoko , Morita Tatsuya , Shima Yasuo , Miyashita Mitsunori 
Published: October 2021

Abstract
Purpose: This study aimed to examine the effect of financial burden of cancer treatment from diagnosis to end-of-life on treatment withdrawal or change in Japan. Methods: This study was part of a nationwide survey of bereaved family members of cancer patients in Japan (J-HOPE2016 study). We asked questions regarding withdrawal or change of cancer treatment (stratified according to whether the treatment was recommended by physicians or based on the patients’ request), experiences of financial difficulties in coping with cancer treatment expenses, and the participants’ socioeconomic background. We conducted descriptive analyses and used logistic regression to examine the factors related to withdrawal or change of cancer treatment. Results: Approximately 7.5% of participants reported withdrawal or change of cancer treatment for financial reasons. The experiences of financial difficulties in coping with cancer treatment expenses such as using up all or a portion of one’s savings (OR=2.14, 95% CI=1.14-4.04, p=0.018 / OR=3.45, 95% CI=1.52-7.81, p=0.003) and subjective financial burden (OR=2.54, 95% CI=1.25-5.14, p=0.010 / OR=3.89, 95% CI=1.68-9.00, p=0.002) were significantly related to withdrawal or change of cancer treatment (recommended by physicians / based on patient request). Conclusion: Fewer participants reported withdrawal or change of cancer treatment than in previous studies, which might reflect the characteristics of the Japanese health-care system. However, there are patients in Japan who withdraw or change cancer treatment for financial reasons. Medical staff should consider financial toxicity as a serious side effect and assist patients in their decision-making regarding treatment while considering their socioeconomic background.
Unemployment Rate, Clean Energy And Ecological Footprint In OECD Countries
Authors: Ng Cheong-Fatt , Yii Kwang-Jing , Lau Lin-Sea , Go You-How 
Published: October 2021

Abstract
OECD countries have encountered the challenges of improving the environmental sustainability while maintaining economic growth by not impairing employment. Designing green policies with the consideration of clean energy is claimed to resolve the mentioned challenges. This study attempts to reexamine the environmental Kuznets curve (EKC) hypothesis by using ecological footprint as an indicator of environmental degradation. Besides, our study aims to test the validity of environmental Phillips curve and role of clean energy on ecological footprint. Our data cover a panel of 36 OECD countries from 1995-2015. We adopt the second generation panel unit root and cointegration test to account for the presence of cross section dependence (CSD). Moreover, the long-run relationship is estimated using Common Correlated Effect Mean Group (CCEMG) and Augmented Mean Group (AMG) that are robust to CSD. Our results are able to provide valuable insights for environmental policy recommendations in OECD countries.
Fuzzy Adaptive Controller Design for Double-pendulum Tower Crane with Distribute Mass Payload
Authors: Sun Zheng , Ouyang Huimin 
Published: October 2021

Abstract
As a kind of high-efficiency transportation tools, tower cranes are widely used in construction site. With the increasing volume and mass of payload being transported, the researches of distributed mass payload (DMP) problems have been paid more and more attentions. However, most of the existing control algorithms designed for the concentrated mass payload (CMP) are not enough to meet the needs of actual production. The difference between DMP and CMP is mainly manifested in that the remaining payload swing caused by inertial torque of DMP cannot be effectively suppressed, which leads to safety hazards. In addition, due to the different working environment, accurate system parameters (such as mechanical frictions, air frictions ) are hard to obtain, which leads to errors in their positioning. To solve the above issues, first, we establish mathematical model of a double-pendulum tower crane with distributed mass payload (DTCDMP) and carry out dynamic analysis. Then we propose a fuzzy adaptive control method, which has a good tracking effect against external disturbances and parameter uncertainties, and the method can achieve accurate positioning and effective anti-swing. Then, the Lyapunov technology and LaSalle's invariance principle are used to rigorously prove the stability of the system. Finally, on the basis of tracking the S-shaped trajectories, the effectiveness and robustness of the proposed controller are verified through multi-group comparative experiments.