bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prioritizing climate‐smart agriculture: An organizational and temporal review
Authors: Gardezi Maaz , Michael Semhar , Stock Ryan , Vij Sumit , Ogunyiola Ayorinde , Ishtiaque Asif 
Published: December 2021

AbstractExtant systematic literature reviews on the topic of climate smart agriculture (CSA) have mainly focused on two issues: reviewing framing of the CSA discourse in the academic and policy literature; and policy initiatives in the Global South that enhance the adoption of climate‐smart agricultural practices. Yet, there is little systematic investigation into how international organizations can help smallholder farmers manage agricultural systems to respond to climate change. Analyzing these organization's priorities and highlighting their knowledge gaps are crucial for designing future pathways of CSA. We intend to use this article to identify overarching CSA themes that can guide large international organizations to focus their CSA agenda in the hope of achieving goals associated with food security and sustainable intensification. We specifically ask the following question:How have the key CSA topics and themes emerged in the gray literature of international organizations between 2010 and 2020?We adopted a topic modeling approach to identify how six international organizations engaged with several topics related to CSA. Following the Latent Dirichlet Allocation (LDA) approach, we identified eight topics in the documents, representing four overarching themes: gender research, weather and climate, CSA management and food security. We found that there is insufficient discussion on the issues relating to governance measures and gender mainstreaming, with a larger focus on techno‐managerial measures of CSA. We conclude that research and training related to CSA must offer opportunities for marginalized and disproportionately vulnerable populations to participate and raise their voices and share innovative ideas at different levels of governance.This article is categorized under:Climate and Development > Social Justice and the Politics of DevelopmentVulnerability and Adaptation to Climate Change > Institutions for Adaptation
Direct nose to the brain nanomedicine delivery presents a formidable challenge
Authors: Yokel Robert A. 
Published: December 2021

AbstractThis advanced review describes the anatomical and physiological barriers and mechanisms impacting nanomedicine translocation from the nasal cavity directly to the brain. There are significant physiological and anatomical differences in the nasal cavity, olfactory area, and airflow reaching the olfactory epithelium between humans and experimentally studied species that should be considered when extrapolating experimental results to humans. Mucus, transporters, and tight junction proteins present barriers to material translocation across the olfactory epithelium. Uptake of nanoparticles through the olfactory mucosa and translocation to the brain can be intracellular via cranial nerves (intraneuronal) or other cells of the olfactory epithelium, or extracellular along cranial nerve pathways (perineural) and surrounding blood vessels (perivascular, the glymphatic system). Transport rates vary greatly among the nose to brain pathways. Nanomedicine physicochemical properties (size, surface charge, surface coating, and particle stability) can affect uptake efficiency, which is usually less than 5%. Incorporation of therapeutic agents in nanoparticles has been shown to produce pharmacokinetic and pharmacodynamic benefits. Assessment of adverse effects has included olfactory mucosa toxicity, ciliotoxicity, and olfactory bulb and brain neurotoxicity. The results have generally suggested the investigated nanomedicines do not present significant toxicity. Research needs to advance the understanding of nanomedicine translocation and its drug cargo after intranasal administration is presented.This article is categorized under:
Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease
Therapeutic Approaches and Drug Discovery > Emerging Technologies
Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials
Consistent higher order $$ \sigma \left(\mathcal{GG}\to h\right) $$, $$ \Gamma \left(h\to \mathcal{GG}\right) $$ and Γ(h → γγ) in geoSMEFT
Authors: Corbett Tyler , Martin Adam , Trott Michael 
Published: December 2021

Abstract
We report consistent results for Γ(h → γγ), $$ \sigma \left(\mathcal{GG}\to h\right) $$
σ

GG
→
h

and $$ \Gamma \left(h\to \mathcal{GG}\right) $$
Γ

h
→
GG

in the Standard Model Effective Field Theory (SMEFT) perturbing the SM by corrections $$ \mathcal{O}\left({\overline{\upsilon}}_T^2/16{\pi}^2{\Lambda}^2\right) $$
O

υ
¯

T
2

/
16

π
2

Λ
2

in the Background Field Method (BFM) approach to gauge fixing, and to $$ \mathcal{O}\left({\overline{\upsilon}}_T^4/{\Lambda}^4\right) $$
O

υ
¯

T
4

/

Λ
4

using the geometric formulation of the SMEFT. We combine and modify recent results in the literature into a complete set of consistent results, uniforming conventions, and simultaneously complete the one loop results for these processes in the BFM. We emphasize calculational scheme dependence present across these processes, and how the operator and loop expansions are not independent beyond leading order. We illustrate several cross checks of consistency in the results.
Asymptotic symmetries in Carrollian theories of gravity
Authors: Pérez Alfredo 
Published: December 2021

Abstract
Asymptotic symmetries in Carrollian gravitational theories in 3+1 space and time dimensions obtained from “magnetic” and “electric” ultrarelativistic contractions of General Relativity are analyzed. In both cases, parity conditions are needed to guarantee a finite symplectic term, in analogy with Einstein gravity. For the magnetic contraction, when Regge-Teitelboim parity conditions are imposed, the asymptotic symmetries are described by the Carroll group. With Henneaux-Troessaert parity conditions, the asymptotic symmetry algebra corresponds to a BMS-like extension of the Carroll algebra. For the electric contraction, because the lapse function does not appear in the boundary term needed to ensure a well-defined action principle, the asymptotic symmetry algebra is truncated, for Regge-Teitelboim parity conditions, to the semidirect sum of spatial rotations and spatial translations. Similarly, with Henneaux-Troessaert parity conditions, the asymptotic symmetries are given by the semidirect sum of spatial rotations and an infinite number of parity odd supertranslations. Thus, from the point of view of the asymptotic symmetries, the magnetic contraction can be seen as a smooth limit of General Relativity, in contrast to its electric counterpart.
Hepatitis-B-Virus-Infektionen und impfinduzierte Immunität: die Rolle von soziodemografischen Determinanten
Authors: Brodzinski Annika , Neumeyer-Gromen Angela , Dudareva Sandra , Zimmermann Ruth , Latza Ute , Bremer Viviane , Poethko-Müller Christina 
Published: December 2021

Zusammenfassung
Hintergrund und Ziel
Trotz niedriger Prävalenz der Hepatitis-B-Virus-(HBV-)Infektion in Deutschland ist es wichtig, vulnerable Gruppen und Ansatzpunkte für die Prävention zu identifizieren. In ersten Analysen der „Studie zur Gesundheit Erwachsener in Deutschland“ (DEGS1, 2008–2011) waren HBV-Infektion und -Impfung mit sozidemografischen Determinanten assoziiert. In dieser Arbeit werden die Ergebnisse im Detail untersucht.

Material und Methoden
In DEGS1 lag für 7046 Teilnehmende (Alter: 18–79 Jahre) eine HBV-Serologie vor. Die stattgehabte HBV-Infektion war durch Antikörper gegen das Hepatitis-B-Core-Antigen (Anti-HBc) definiert, die impfinduzierte Immunität durch alleinigen Nachweis von Antikörpern gegen das Hepatitis-B-Surface-Antigen (Anti-HBs). Seroprävalenzen von HBV-Infektions- und -Impfstatus wurden geschlechtsstratifiziert geschätzt und Assoziationen mit Alter, Gemeindegröße, Einkommen, formaler Bildung, Krankenversicherung und Migrationsgeneration in logistischen Regressionen analysiert.

Ergebnisse
Die HBV-Infektion war bei Männern und Frauen unabhängig mit den Altersgruppen 34–64 und ≥ 65 Jahre, erster Migrationsgeneration und Leben in größeren Gemeinden assoziiert, zudem bei Männern mit niedrigem Einkommen und bei Frauen mit niedriger Bildung. Die impfinduzierte Immunität war bei Männern und Frauen unabhängig mit den Altersgruppen 18–33 und 34–64 Jahre, mittlerer und hoher Bildung und hohem Einkommen assoziiert, darüber hinaus bei Männern mit mittlerem Einkommen und privater Krankenversicherung und bei Frauen mit fehlendem Migrationshintergrund.

Diskussion
Die Berücksichtigung von Migrationsstatus, Einkommen und Bildung könnte zur zielgenauen Ausrichtung der HBV-Prävention beitragen.
Development of SARS-CoV-2 packaged RNA reference material for nucleic acid testing
Authors: Lee Sang-Soo , Kim Seil , Yoo Hee Min , Lee Da-Hye , Bae Young-Kyung 
Published: December 2021

AbstractNucleic acid tests to detect the SARS-CoV-2 virus have been performed worldwide since the beginning of the COVID-19 pandemic. For the quality assessment of testing laboratories and the performance evaluation of molecular diagnosis products, reference materials (RMs) are required. In this work, we report the production of a lentiviral SARS-CoV-2 RM containing approximately 12 kilobases of its genome including common diagnostics targets such as RdRp, N, E, and S genes. The RM was measured with multiple assays using two different digital PCR platforms. To measure the homogeneity and stability of the lentiviral SARS-CoV-2 RM, reverse transcription droplet digital PCR (RT-ddPCR) was used with in-house duplex assays. The copy number concentration of each target gene in the extracted RNA solution was then converted to that of the RM solution. Their copy number values are measured to be from 1.5 × 105 to 2.0 × 105 copies/mL. The RM has a between-bottle homogeneity of 4.80–8.23% and is stable at 4 °C for 1 week and at −70 °C for 6 months. The lentiviral SARS-CoV-2 RM closely mimics real samples that undergo identical pre-analytical processes for SARS-CoV-2 molecular testing. By offering accurate reference values for the absolute copy number of viral target genes, the developed RM can be used to improve the reliability of SARS-CoV-2 molecular testing.
[18F]FDG-PET accurately identifies pathological response early upon neoadjuvant immune checkpoint blockade in head and neck squamous cell carcinoma
Authors: Vos Joris L. , Zuur Charlotte L. , Smit Laura A. , de Boer Jan Paul , Al-Mamgani Abrahim , van den Brekel Michiel W. M. , Haanen John B. A. G. , Vogel Wouter V. 
Published: December 2021

Abstract
Purpose
To investigate the utility of [18F]FDG-PET as an imaging biomarker for pathological response early upon neoadjuvant immune checkpoint blockade (ICB) in patients with head and neck squamous cell carcinoma (HNSCC) before surgery.

Methods
In the IMCISION trial (NCT03003637), 32 patients with stage II‒IVb HNSCC were treated with neoadjuvant nivolumab with (n = 26) or without (n = 6) ipilimumab (weeks 1 and 3) before surgery (week 5). [18F]FDG-PET/CT scans were acquired at baseline and shortly before surgery in 21 patients. Images were analysed for SUVmax, SUVmean, metabolic tumour volume (MTV), and total lesion glycolysis (TLG). Major and partial pathological responses (MPR and PPR, respectively) to immunotherapy were identified based on the residual viable tumour in the resected primary tumour specimen (≤ 10% and 11–50%, respectively). Pathological response in lymph node metastases was assessed separately. Response for the 2 [18F]FDG-PET-analysable patients who did not undergo surgery was determined clinically and per MR-RECIST v.1.1. A patient with a primary tumour MPR, PPR, or primary tumour MR-RECIST-based response upon immunotherapy was called a responder.

Results
Median ΔSUVmax, ΔSUVmean, ΔMTV, and ΔTLG decreased in the 8 responders and were significantly lower compared to the 13 non-responders (P = 0.05, P = 0.002, P < 0.001, and P < 0.001). A ΔMTV or ΔTLG of at least − 12.5% detected a primary tumour response with 95% accuracy, compared to 86% for the EORTC criteria. None of the patients with a ΔTLG of − 12.5% or more at the primary tumour site developed a relapse (median FU 23.0 months since surgery). Lymph node metastases with a PPR or MPR (5 metastases in 3 patients) showed a significant decrease in SUVmax (median − 3.1, P = 0.04). However, a SUVmax increase (median + 2.1) was observed in 27 lymph nodes (in 11 patients), while only 13 lymph nodes (48%) contained metastases in the corresponding neck dissection specimen.

Conclusions
Primary tumour response assessment using [18F]FDG-PET-based ΔMTV and ΔTLG accurately identifies pathological responses early upon neoadjuvant ICB in HNSCC, outperforming the EORTC criteria, although pseudoprogression is seen in neck lymph nodes. [18F]FDG-PET could, upon validation, select HNSCC patients for response-driven treatment adaptation in future trials.

Trial registration
https://www.clinicaltrials.gov/, NCT03003637, December 28, 2016.
Quantitative imaging biomarkers of immune-related adverse events in immune-checkpoint blockade-treated metastatic melanoma patients: a pilot study
Authors: Hribernik Nežka , Huff Daniel T , Studen Andrej , Zevnik Katarina , Klaneček Žan , Emamekhoo Hamid , Škalic Katja , Jeraj Robert , Reberšek Martina 
Published: December 2021

Abstract
Purpose
To develop quantitative molecular imaging biomarkers of immune-related adverse event (irAE) development in malignant melanoma (MM) patients receiving immune-checkpoint inhibitors (ICI) imaged with 18F-FDG PET/CT.

Methods
18F-FDG PET/CT images of 58 MM patients treated with anti-PD-1 or anti-CTLA-4 ICI were retrospectively analyzed for indication of irAE. Three target organs, most commonly affected by irAE, were considered: bowel, lung, and thyroid. Patient charts were reviewed to identify which patients experienced irAE, irAE grade, and time to irAE diagnosis. Target organs were segmented using a convolutional neural network (CNN), and novel quantitative imaging biomarkers — SUV percentiles (SUVX%) of 18F-FDG uptake within the target organs — were correlated with the clinical irAE status. Area under the receiver-operating characteristic curve (AUROC) was used to quantify irAE detection performance. Patients who did not experience irAE were used to establish normal ranges for target organ 18F-FDG uptake.

Results
A total of 31% (18/58) patients experienced irAE in the three target organs: bowel (n=6), lung (n=5), and thyroid (n=9). Optimal percentiles for identifying irAE were bowel (SUV95%, AUROC=0.79), lung (SUV95%, AUROC=0.98), and thyroid (SUV75%, AUROC=0.88). Optimal cut-offs for irAE detection were bowel (SUV95%>2.7 g/mL), lung (SUV95%>1.7 g/mL), and thyroid (SUV75%>2.1 g/mL). Normal ranges (95% confidence interval) for the SUV percentiles in patients without irAE were bowel [1.74, 2.86 g/mL], lung [0.73, 1.46 g/mL], and thyroid [0.86, 1.99 g/mL].

Conclusions
Increased 18F-FDG uptake within irAE-affected organs provides predictive information about the development of irAE in MM patients receiving ICI and represents a potential quantitative imaging biomarker for irAE. Some irAE can be detected on 18F-FDG PET/CT well before clinical symptoms appear.
Serum n-6 polyunsaturated fatty acids and risk of atrial fibrillation: the Kuopio Ischaemic Heart Disease Risk Factor Study
Authors: Tajik Behnam , Tuomainen Tomi-Pekka , Isanejad Masoud , Salonen Jukka T. , Virtanen Jyrki K. 
Published: December 2021

Abstract
Purpose
N-6 polyunsaturated fatty acids (PUFA), particularly linoleic acid (LA), have been associated with lower risk of coronary heart disease (CHD), but little is known about their antiarrhythmic properties. We investigated the association of the serum n-6 PUFAs with the risk of atrial fibrillation (AF), the most common type of cardiac arrhythmia.

Methods
The study included 2450 men from the Kuopio Ischaemic Heart Disease Risk Factor Study, aged 42–60 years at baseline. The total n-6 PUFA includes linoleic acid (LA), arachidonic acid (AA), γ-linolenic acid (GLA) and dihomo-γ-linolenic acid (DGLA). Cox proportional hazards regression was used to estimate hazard ratio (HR) of incident events.

Results
During the mean follow-up of 22.4 years, 486 AF cases occurred. The multivariable-adjusted HR in the highest versus the lowest quartile of total serum n-6 PUFA concentration was 0.79 (95% CI 0.58–1.08, P trend = 0.04). When evaluated individually, only serum LA concentration was inversely associated with AF risk (multivariable-adjusted extreme-quartile HR 0.69, 95% CI 0.51–0.94, P trend = 0.02). These associations were stronger among the men without history of CHD or congestive heart failure at baseline, compared to men with such disease history (P for interaction = 0.05 for total n-6 PUFA and LA). Similar associations were observed with dietary LA and AA intakes. No significant associations were observed with serum AA, GLA or DGLA concentrations.

Conclusions
Higher circulating concentration and dietary intake of n-6 PUFA, mainly LA, are associated with lower risk of AF, especially among men without history of CHD or congestive heart failure.
Non-contrast myocardial perfusion in rest and exercise stress using systolic flow-sensitive alternating inversion recovery
Authors: Henningsson Markus , Carlhäll Carl-Johan , Ebbers Tino , Kihlberg Johan 
Published: December 2021

Abstract
Objective
To evaluate systolic flow-sensitive alternating inversion recovery (FAIR) during rest and exercise stress using 2RR (two cardiac cycles) or 1RR intervals between inversion pulse and imaging.

Materials and methods
1RR and 2RR FAIR was implemented on a 3T scanner. Ten healthy subjects were scanned during rest and stress. Stress was performed using an in-bore ergometer. Heart rate, mean myocardial blood flow (MBF) and temporal signal-to-noise ratio (TSNR) were compared using paired t tests.

Results
Mean heart rate during stress was higher than rest for 1RR FAIR (85.8 ± 13.7 bpm vs 63.3 ± 11.1 bpm; p < 0.01) and 2RR FAIR (83.8 ± 14.2 bpm vs 63.1 ± 10.6 bpm; p < 0.01). Mean stress MBF was higher than rest for 1RR FAIR (2.97 ± 0.76 ml/g/min vs 1.43 ± 0.6 ml/g/min; p < 0.01) and 2RR FAIR (2.8 ± 0.96 ml/g/min vs 1.22 ± 0.59 ml/g/min; p < 0.01). Resting mean MBF was higher for 1RR FAIR than 2RR FAIR (p < 0.05), but not during stress. TSNR was lower for stress compared to rest for 1RR FAIR (4.52 ± 2.54 vs 10.12 ± 3.69; p < 0.01) and 2RR FAIR (7.36 ± 3.78 vs 12.41 ± 5.12; p < 0.01). 2RR FAIR TSNR was higher than 1RR FAIR for rest (p < 0.05) and stress (p < 0.001).

Discussion
We have demonstrated feasibility of systolic FAIR in rest and exercise stress. 2RR delay systolic FAIR enables non-contrast perfusion assessment during stress with relatively high TSNR.
Modelling discontinuity control on the development of Hell’s Mouth landslide
Authors: He Lingfeng , Coggan John , Stead Doug , Francioni Mirko , Eyre Matthew 
Published: December 2021

AbstractThis paper focuses on numerical modelling and back analysis of the Hell’s Mouth landslide to provide improved understanding of the evolution of a section of the north coast of Cornwall, UK. Discontinuity control is highlighted through the formation of a ‘zawn’ or inlet, the occurrence of two successive landslides and evidence of ongoing instability through opening of tension cracks behind the cliff top. Several integrated remote sensing (RS) techniques have been utilised for data acquisition to characterise the slope geometry, landslide features and tension crack extent and development. In view of the structural control on the rock slope failures, a 3D distinct element method (DEM) code incorporating a discrete fracture network and rigid blocks has been adopted for the stability analysis. The onset and opening of tension cracks behind the modelled slope failure zones has also been studied by analysing the displacements of two adjoining landslide blocks, between which, a joint-related tension crack developed. In addition, a sensitivity analysis has been undertaken to provide further insight into the influence of key discontinuity parameters (i.e. dip, dip direction, persistence and friction angle) on the stability of this section of the coastline. Numerical modelling and field observations indicate that block removal and preferential erosion along a fault resulted in the formation of the inlet. The development of the inlet provides daylighting conditions for discontinuities exposed on the inlet slope wall, triggering the initial landslide which occurred on 23rd September 2011. Numerical modelling, and evidence from a video of the initial landslide, suggests that the cliff instability is characterised by a combination of planar sliding, wedge sliding and toppling modes of failure controlled by the discrete fracture network geometry.
Provision of social-norms feedback to general practices whose antibiotic prescribing is increasing: a national randomized controlled trial
Authors: Gold Natalie , Ratajczak Michael , Sallis Anna , Saei Ayoub , Watson Robin , van Schaik Paul , Bowen Sarah , Chadborn Tim 
Published: December 2021

Abstract
Aim
The Chief Medical Officer of England writes an annual social-norms-feedback letter to the highest antibiotic-prescribing GP practices. We investigated whether sending a social-norms-feedback letter to practices whose prescribing was increasing would reduce prescribing.

Subject and methods
We conducted a two-armed randomised controlled trial amongst practices whose STAR-PU-adjusted prescribing was in the 20th–95th percentiles and had increased by > 4% year-on-year in the 2 previous financial years. Intervention practices received a letter on 1st March 2018 stating ‘The great majority (80%) of practices in England reduced or stabilised their antibiotic prescribing rates in 2016/17. However, your practice is in the minority that have increased their prescribing by more than 4%.’. Control practices received no letter. The primary outcome was the STAR-PU-adjusted rate of antibiotic prescribing in the months from March to September 2018.

Results
We randomly assigned 930 practices; ten closed or merged pre-trial, leaving 920 practices — 448 in the intervention and 472 in the control. An autoregressive and moving average model of first order ARMA(1,1) correlation structure showed no effect of the intervention (β < −0.01, z = −0.50, p = 0.565). Prescribing reduced over time in both arms (β < −0.01, z = −36.36, p < 0.001).

Conclusions
A social-norms-feedback letter to practices whose prescribing was increasing did not decrease prescribing compared to no letter.

Trial registration
NCT03582072.