bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acceptability of the Dapivirine Vaginal Ring for HIV-1 Prevention and Association with Adherence in a Phase III Trial
Authors: Mayo Ashley J. , Browne Erica N. , Montgomery Elizabeth T. , Torjesen Kristine , Palanee-Phillips Thesla , Jeenarain Nitesha , Seyama Linly , Woeber Kubashni , Harkoo Ishana , Reddy Krishnaveni , Tembo Tchangani , Mutero Prisca , Tauya Thelma , Chitukuta Miria , Gati Mirembe Brenda , Soto-Torres Lydia , Brown Elizabeth R. , Baeten Jared M. , van der Straten Ariane ,   for the MTN-020/ASPIRE study team, Baeten Jared , Palanee-Phillips Thesla , Brown Elizabeth , Soto-Torres Lydia , Schwartz Katie , Makanani Bonus , Martinson Francis , Bekker Linda-Gail , Govender Vaneshree , Siva Samantha , Gaffoor Zakir , Naidoo Logashvari , Pather Arendevi , Jeenarain Nitesha , Nair Gonasagrie , Matovu Flavia , Mgodi Nyaradzo , Mhlanga Felix 
Published: March 2021

AbstractWe evaluated the acceptability of the 25 mg dapivirine vaginal ring (DVR) as an HIV prevention intervention and its influence on DVR adherence in the MTN-020/ASPIRE phase III trial. Acceptability measures were captured using ACASI at month 3 and end of product use (median 24 months, IQR 15–30). Monthly returned rings were classified as nonadherent if dapivirine release rate was ≤ 0.9 mg/month. Associations between acceptability measures and nonadherence were estimated using Poisson regression models with robust standard errors. At month 3 (N = 2334), 88% reported DVR was comfortable, 80% were unaware of it during daily activities, and 74% never felt it during sex. At exit, 66% were ‘very likely’ to use DVR in the future. Acceptability was found to differ significantly by country across several measures including wearing the ring during sex, during menses, partner acceptability, impact on sexual pleasure and willingness to use the ring in the future. Risk of nonadherence at month 12 was elevated if DVR was felt during sex at month 3 (aRR 1.67, 95% CI 1.26, 2.23). Risk of nonadherence in the last year of study participation was elevated if, at exit, participants minded wearing during sex (aRR 2.08, 95% CI 1.52, 2.85), during menses (aRR 1.57, 95% CI 1.06, 2.32), reported a problematic change to the vaginal environment (aRR 1.57, 95% CI 1.12, 2.21), and were not “very likely” to use DVR in the future (aRR 1.31, 95% CI 1.02, 1.68). DVR acceptability was overall high yet varied by country. Addressing perceived ring interference with sex, menses, or problematic changes to the vaginal environment in future interventions could help improve adherence, as could embracing sex-positive messaging related to ring use and increased pleasure.Trial Registration ClinicalTrials.gov Identifier: NCT01617096.
Stagnant peaked free surface released at a sloping beach
Authors: Tyvand Peder A. , Nøland Jonas Kristiansen 
Published: March 2021

AbstractA stagnant free-surface flow is an instantaneous flow field of pure acceleration with zero velocity and a deformed surface. There exists a potential-flow acceleration field. With zero velocity and the acceleration field given, there is a limiting free-surface position which possesses one peak at its point of highest elevation. By complex analysis, it can be shown that the surface peak has a right angle. We elaborate on an elementary model of two-dimensional stagnant free-surface flow with a peak. Our model may serve to describe a situation of maximal single-wave run-up with a given energy at a uniformly sloping beach. The highest possible run-up of an incoming solitary wave corresponds to zero kinetic energy. It encompasses an idealized situation where the kinetic wave energy is converted into potential energy in a water mass piling up along the slope to become stagnant at one single moment. Multipoles with singularities outside the fluid domain may give rise to a smooth and gradual deceleration needed for a non-breaking run-up process. A pair of dipoles with an orientation perpendicular to a given slope represents the stagnant acceleration fields with the highest surface peak spatially concentrated along the slope. Thereby, a one-parameter family of surface shapes is constituted, only dependent on the slope angle. The initial flow field, the initial free surface, the initial isobars and the geometric parameters are all calculated for different slope angles.
Identification of a novel sex determining chromosome in cichlid fishes that acts as XY or ZW in different lineages
Authors: Feller Anna F. , Ogi Vera , Seehausen Ole , Meier Joana I. 
Published: March 2021

AbstractSex determination systems are highly conserved among most vertebrates with genetic sex determination, but can be variable and evolve rapidly in some. Here, we study sex determination in a clade with exceptionally high sex chromosome turnover rates. We identify the sex determining chromosomes in three interspecific crosses of haplochromine cichlid fishes from Lakes Victoria and Malawi. We find evidence for different sex determiners in each cross. In the Malawi cross and one Victoria cross the same chromosome is sex-linked but while females are the heterogametic sex in the Malawi species, males are the heterogametic sex in the Victoria species. This chromosome has not previously been reported to be sex determining in cichlids, increasing the number of different chromosomes shown to be sex determining in cichlids to 12. All Lake Victoria species of our crosses are less than 15,000 years divergent, and we identified different sex determiners among them. Our study provides further evidence for the diversity and evolutionary flexibility of sex determination in cichlids, factors which might contribute to their rapid adaptive radiations.
Multiple steady statehood: the roles of productive and extractive capacities
Authors: Lagerlöf Nils-Petter 
Published: March 2021

AbstractThis paper proposes a model of statehood, defined as elite extraction of resources from a subject population. Different from most of the existing literature, the size of the subject population evolves endogenously in a Malthusian fashion, and the elite take into account the effects on future population levels when taxing the current population. The elite can spend extracted resources by investing in productive and extractive capacities. Productive capacity increases the size of the pie, while extractive capacity makes it easier for the elite to tax it. Together—but not each on its own—these two types of investment can give rise to multiple steady-state equilibria, such that one steady state has both a higher rate of extraction, and higher population density and output, than the other steady state. The model can also account for a positive empirical relationship between land productivity and state antiquity among countries with relatively late state development.
A review of modelling methodologies for flood source area (FSA) identification
Authors: Singh Amrie , Dawson David , Trigg Mark , Wright Nigel 
Published: March 2021

AbstractFlooding is an important global hazard that causes an average annual loss of over 40 billion USD and affects a population of over 250 million globally. The complex process of flooding depends on spatial and temporal factors such as weather patterns, topography, and geomorphology. In urban environments where the landscape is ever-changing, spatial factors such as ground cover, green spaces, and drainage systems have a significant impact. Understanding source areas that have a major impact on flooding is, therefore, crucial for strategic flood risk management (FRM). Although flood source area (FSA) identification is not a new concept, its application is only recently being applied in flood modelling research. Continuous improvements in the technology and methodology related to flood models have enabled this research to move beyond traditional methods, such that, in recent years, modelling projects have looked beyond affected areas and recognised the need to address flooding at its source, to study its influence on overall flood risk. These modelling approaches are emerging in the field of FRM and propose innovative methodologies for flood risk mitigation and design implementation; however, they are relatively under-examined. In this paper, we present a review of the modelling approaches currently used to identify FSAs, i.e. unit flood response (UFR) and adaptation-driven approaches (ADA). We highlight their potential for use in adaptive decision making and outline the key challenges for the adoption of such approaches in FRM practises.
CycleGAN for interpretable online EMT compensation
Authors: Krumb Henry , Das Dhritimaan , Chadda Romol , Mukhopadhyay Anirban 
Published: March 2021

Abstract
Purpose
Electromagnetic tracking (EMT) can partially replace X-ray guidance in minimally invasive procedures, reducing radiation in the OR. However, in this hybrid setting, EMT is disturbed by metallic distortion caused by the X-ray device. We plan to make hybrid navigation clinical reality to reduce radiation exposure for patients and surgeons, by compensating EMT error.

Methods
Our online compensation strategy exploits cycle-consistent generative adversarial neural networks (CycleGAN). Positions are translated from various bedside environments to their bench equivalents, by adjusting their z-component. Domain-translated points are fine-tuned on the x–y plane to reduce error in the bench domain. We evaluate our compensation approach in a phantom experiment.

Results
Since the domain-translation approach maps distorted points to their laboratory equivalents, predictions are consistent among different C-arm environments. Error is successfully reduced in all evaluation environments. Our qualitative phantom experiment demonstrates that our approach generalizes well to an unseen C-arm environment.

Conclusion
Adversarial, cycle-consistent training is an explicable, consistent and thus interpretable approach for online error compensation. Qualitative assessment of EMT error compensation gives a glimpse to the potential of our method for rotational error compensation.
Application of a Lumped Multi-Section Model for Analyzing the Thermal Performance of a Small-Scale Biomass Boiler
Authors: Polesek-Karczewska Sylwia , Wardach-Święcicka Izabela , Kardaś Dariusz , Turzyński Tomasz 
Published: March 2021

AbstractThe stationary lumped-cell model was developed and used to simulate the thermal characteristics of domestic biomass boiler with helically coiled tube heat exchanger (HCHE). The device serves as the heat source for ORC (Organic Rankine Cycle) unit and utilizes the thermal oil as the medium transferring the heat to the unit. Most of studies available in the literature refer to the CFD simulations for water flow in tube coils or in one- or two-turn coil elements. These investigations are basically focused on the determination of Nusselt number. The proposed herein model aims at determining the thermal performance of flue gas-oil HCHE while providing low CPU time. To demonstrate the model possibilities, it was used to predict the flue gas temperatures at the inlet and outlet from the heat exchange zone, based on measurement data regarding the outlet temperature of thermal oil. Six test series were considered. The computation results appeared to be in satisfactory agreement with experimental results (the discrepancies do not exceed 12%). The investigations showed that the used approach may be recommended as an alternative method that allows for fast prediction of thermal parameters for units of complex geometries, in particular the multi-coil heat exchangers.
FunQ: Measuring the fun experience of a learning activity with adolescents
Authors: Tisza Gabriella , Markopoulos Panos 
Published: March 2021

AbstractResearchers and practitioners in learning sciences, educational technology and child-computer interaction often argue that fun is an essential element of learning. Therefore, researchers in the above fields aim to explore how learning activities could be made more enjoyable in order to facilitate engagement in the learning process and to improve the learning outcomes. Despite such wide interest, there has been little systematic effort to define and measure fun. The herein introduced research aims to (a) define the term “fun” and (b) to create a tool for the reliable measurement of it. In the first study testing the initial item pool 75 students (μage = 11.78); in the think-aloud study testing the comprehensibility of the items six 11-year-old children and in the final validation study, 128 students (μage = 12.15) participated. We applied a deductive scale development approach. For the model testing, CFA was used and second-order latent variable models were fitted. In this paper, we conceptualize the term of fun and introduce the final 18-item version of the FunQ that consists of six dimensions (Autonomy, Challenge, Delight, Immersion, Loss of Social Barriers and Stress) and bears with the appropriate validity and reliability measures (ωoverall = 0.875 and ωpartial = 0.864; RMSEA = 0.052 and SRMR = 0.072). We contribute with (a) a review of the literature regarding the concept of fun, (b) a conception of fun as a multidimensional theoretically motivated concept, (c) a multidimensional instrument for assessing experienced fun—the FunQ—and (d) a psychometric evaluation of the proposed instrument. FunQ is put forward as a reliable and much-needed addition to the current palette of instruments.
Our future in the Anthropocene biosphere
Authors: Folke Carl , Polasky Stephen , Rockström Johan , Galaz Victor , Westley Frances , Lamont Michèle , Scheffer Marten , Österblom Henrik , Carpenter Stephen R. , Chapin F. Stuart , Seto Karen C. , Weber Elke U. , Crona Beatrice I. , Daily Gretchen C. , Dasgupta Partha , Gaffney Owen , Gordon Line J. , Hoff Holger , Levin Simon A. , Lubchenco Jane , Steffen Will , Walker Brian H. 
Published: March 2021

AbstractThe COVID-19 pandemic has exposed an interconnected and tightly coupled globalized world in rapid change. This article sets the scientific stage for understanding and responding to such change for global sustainability and resilient societies. We provide a systemic overview of the current situation where people and nature are dynamically intertwined and embedded in the biosphere, placing shocks and extreme events as part of this dynamic; humanity has become the major force in shaping the future of the Earth system as a whole; and the scale and pace of the human dimension have caused climate change, rapid loss of biodiversity, growing inequalities, and loss of resilience to deal with uncertainty and surprise. Taken together, human actions are challenging the biosphere foundation for a prosperous development of civilizations. The Anthropocene reality—of rising system-wide turbulence—calls for transformative change towards sustainable futures. Emerging technologies, social innovations, broader shifts in cultural repertoires, as well as a diverse portfolio of active stewardship of human actions in support of a resilient biosphere are highlighted as essential parts of such transformations.
A numerical scheme for the solution of neutral integro-differential equations including variable delay
Authors: Gürbüz Burcu 
Published: March 2021

AbstractIn this study, an effective numerical technique has been introduced for finding the solutions of the first-order integro-differential equations including neutral terms with variable delays. The problem has been defined by using the neutral integro-differential equations with initial value. Then, an alternative numerical method has been introduced for solving these type of problems. The method is expressed by fundamental matrices, Laguerre polynomials with their matrix forms. Besides, the solution has been obtained by using the collocation points with regard to the reduced system of algebraic equations and Laguerre series.
Empirical investigation of the relationship between bilingualism and social flexibility
Authors: Champoux-Larsson Marie-France , Dylman Alexandra S. , Esteves Francisco 
Published: March 2021

AbstractRecently, a relationship between bilingualism and enhanced social flexibility has been suggested. However, research on the subject is scarce and what little exists is limited by several conceptual and methodological concerns. In the current study, we attempted to (a) replicate the findings from a study by Ikizer and Ramírez-Esparza (Bilingualism: Language and Cognition 21:957–969, 2018) by using the scales that the authors developed, and (b) test the concept of social flexibility experimentally with a switch-task using socially relevant stimuli. In the first part, participants (n = 194) filled out the scales developed by Ikizer and Ramírez-Esparza. We could not find that bilingualism leads to enhanced social flexibility. We did, however, find that higher level of education led to higher scores on the social flexibility scale. In the second part, a subsample (n = 74) from Part 1 completed a task where they were asked to identify the congruency between a face and a voice based on either gender or emotion, and to switch between these two tasks. The experimental task did not show an advantage for the bilingual participants. On the contrary, higher proficiency in a second language led to lower accuracy in the congruent emotion condition, while level of education led to higher accuracy in that same condition. We suggest that factors other than bilingualism, such as level of education and biculturalism, most likely drove the effect found both in the current study and originally by Ikizer and Ramírez-Esparza.
Research trends of microplastics in the soil environment: Comprehensive screening of effects
Authors: Kim Shin Woong , Rillig Matthias C. 
Published: March 2021

AbstractWe collated and synthesized previous studies that reported the impacts of microplastics on soil parameters. The data were classified and integrated to screen for the proportion of significant effects, then we suggest several directions to alleviate the current data limitation in future experiments. We compiled 106 datasets capturing significant effects, which were analyzed in detail. We found that polyethylene and pellets (or powders) were the most frequently used microplastic composition and shape for soil experiments. The significant effects mainly occurred in broad size ranges (0.1–1 mm) at test concentrations of 0.1%–10% based on soil dry weight. Polyvinyl chloride and film induced significant effects at lower concentrations compared to other compositions and shapes, respectively. We adopted a species sensitivity distribution (SSD) and soil property effect distribution (SPED) method using available data from soil biota, and for soil properties and enzymes deemed relevant for microplastic management. The predicted-no-effect-concentration (PNEC)-like values needed to protect 95% of soil biota and soil properties was estimated to be between 520 and 655 mg kg−1. This study was the first to screen microplastic levels with a view toward protecting the soil system. Our results should be regularly updated (e.g., quarterly) with additional data as they become available.
Individual, Relational, and Sociocultural Determinants of Sexual Function and Sexual Satisfaction in Ecuador
Authors: Hidalgo Daniela Arcos , Dewitte Marieke 
Published: March 2021

Abstract

Aim
Various individual, relational, and sociocultural variables have been identified as determinants of sexual responding, but these have rarely been investigated in non-Western cultures that are characterized by sexual conservatism. We aimed to explore the role of socioeconomic status and religion, sexual double standards, erotophobia-erotophilia, sexual dysfunctional beliefs, and relationship satisfaction to explain sexual function and satisfaction in Ecuador.

Method
599 participants (431 women and 159 men) completed an online survey.

Main Outcomes Measures
The Female sexual function was predicted by sexual satisfaction, relationship satisfaction, sexual dysfunctional beliefs, and sexual double standards, while the male sexual function was predicted solely by sexual satisfaction. Additionally, female sexual satisfaction was predicted by sexual function, relationship satisfaction, and sexual dysfunctional beliefs, while male sexual satisfaction was predicted by sexual function and relationship satisfaction.

Results
Female Sexual Function Index, International Index of Erectile Function, Brief Sexual Opinion Survey, Sexual Double Standards Scale, Sexual Dysfunctional Beliefs Questionnaire, New Sexual Satisfaction Scale, and Couple Satisfaction Index.

Conclusion
This study provided novel information on the determinants of sexual function and satisfaction within a culture in which conservative religious beliefs still prevail. Results should be interpreted with caution given the unequal distribution of men and women, social desirability and volunteer biases, and the specific COVID-19 pandemic context during which the survey took place. Markers of sexual conservatism were inversely related to sexual function and satisfaction, mainly in women, and may, therefore, be important targets of treatment. Female sexuality seemed more context-dependent than male sexuality, although enhancing the general climate of the relationship may benefit feeling sexually satisfied in both men and women.
Identifying a Safe and Just Corridor for People and the Planet
Authors: Rockström Johan , Gupta Joyeeta , Lenton Timothy M. , Qin Dahe , Lade Steven J. , Abrams Jesse F. , Jacobson Lisa , Rocha Juan C. , Zimm Caroline , Bai Xuemei , Bala Govindasamy , Bringezu Stefan , Broadgate Wendy , Bunn Stuart E. , DeClerck Fabrice , Ebi Kristie L. , Gong Peng , Gordon Chris , Kanie Norichika , Liverman Diana M. , Nakicenovic Nebojsa , Obura David , Ramanathan Veerabhadran , Verburg Peter H. , van Vuuren Detlef P. , Winkelmann Ricarda 
Published: March 2021

AbstractKeeping the Earth system in a stable and resilient state, to safeguard Earth's life support systems while ensuring that Earth's benefits, risks, and related responsibilities are equitably shared, constitutes the grand challenge for human development in the Anthropocene. Here, we describe a framework that the recently formed Earth Commission will use to define and quantify target ranges for a “safe and just corridor” that meets these goals. Although “safe” and “just” Earth system targets are interrelated, we see safe as primarily referring to a stable Earth system and just targets as being associated with meeting human needs and reducing exposure to risks. To align safe and just dimensions, we propose to address the equity dimensions of each safe target for Earth system regulating systems and processes. The more stringent of the safe or just target ranges then defines the corridor. Identifying levers of social transformation aimed at meeting the safe and just targets and challenges associated with translating the corridor to actors at multiple scales present scope for future work.