bluuebunny/crossref_metadata_2025_split huggingface dataset:
STRUCTURAL ELEMENTS OF THE INTELLECTUAL INFRASTRUCTURE POTENTIAL TECHNOLOGICAL DEVELOPMENT
Authors: Миллер Александр Емельянович 
Published: September 2021

В статье исследуются теоретические аспекты потенциала интеллектуальной инфраструктуры технологического развития промышленных предприятий. Раскрыты специфические признаки и обоснованы элементы потенциала интеллектуальной инфраструктуры технологического развития. Предложен универсальный метод оценивания потенциала интеллектуальной инфраструктуры технологического развития.
The article explores theoretical aspects of the potential of the intellectual infrastructure of technological development of industrial enterprises. Specific features are disclosed and elements of potential of intellectual infrastructure of technological development are justified. Universal method of assessment of potential of intellectual infrastructure of technological development is proposed.
THE PROBLEM OF REDUCING THE PAYMENT FOR THE SERVICES OF A REPRESENTATIVE
Authors: Ряполов Никита Александрович , Рубцова Наталья Васильевна 
Published: September 2021

В статье освещена проблема оплаты услуг представителя. Рассмотрена позиция Верховного суда РФ, а также мнение адвокатского сообщества. Представлены точки зрения действующих адвокатов и иных авторов, изучающих данную проблематику. По их мнению, сложившуюся ситуацию не стоит замалчивать, а продолжить активно обсуждать.
The article highlights the problem of paying for the services of a representative. The article considers the position of the Supreme Court of the Russian Federation, as well as the opinion of the legal community. The points of view of current lawyers and other authors studying this problem are presented. In their opinion, the current situation should not be hushed up, but continue to be actively discussed.
BUILDING AN INNOVATIVE OPEN EDUCATION ECOSYSTEM OF A MODERN UNIVERSITY
Authors: Хмелева Галина Анатольевна 
Published: September 2021

В статье обоснована необходимость формирования открытой инновационной образовательной экосистемы как парадигмы современного конкурентного университета. Ключевое значение для такой системы имеют гибкие образовательные стандарты, сокращение количества проверок вузов, проверяемых показателей, технологическое оснащение, цифровые компетенции преподавателей.
The article substantiates the need for the formation of an open innovative educational ecosystem as a paradigm of a modern competitive university. Of key importance for such a system are flexible educational standards, a reduction in the number of inspections of universities, verifiable indicators, technological equipment, and digital competencies of teachers.
IoT Based Image Processing Filters
Authors: Abbas Noor , Shujaa Mohamed Ibrahim , Zghair Entithaar Mhwes 
Published: September 2021

Internet of things (IoT) becomes the backbone of the advanced countries and it has a real contribute to exchange the traditional style or way of practical life, even personal life into smart style, with (IoT) technology the life become more and more easy and professional. internet of things achieves various applications coordinate with sensors and standard protocols to apply what is called machine -to- machine connection (M2M), in this paper we will talk more about the concept of (M2M), the main component of internet of things and finally the common protocols that is used in network, in addition to that this work present an IOT operation with processing system using camera for capturing image and Xilinx system generator(XSG)models for designing image processing algorithms and the result of the processing is an image with black and white for edge detection and Thresholding models and gray color image for gray enhancement model.
Weather dependence of medical rehabilitation efficiency in patients with ischemic heart disease on the resort of the South Coast of Crimea
Authors: Ivaschenko A. S. , Ezhov V. V. , Yezhova L. V. , Yanovskiy T. S. , Mizin V. I. , Yarosh A. M. , Grigoriev P. E. , Pyankov A. F. 
Published: September 2021

The aim of this work is to assess the influence of the climatic and weather characteristics of the South Coast of Crimea (SCC) on the effectiveness of health resort medical rehabilitation (MR) of patients with ischemic heart disease (IHD).Materials and methods. A study was carried out in a group of 276 patients with IHD. The influence of climatic and weather characteristics of the SCC were assessed using the methods developed by the «ARI n.a. I.M. Sechenov» - modified clinical index on weather pathogenicity (CIPP-M) and MR assessment according to the criteria of the» International classification of functioning, disabilities and health» (ICF).Results. Regression equations for the dynamics of the ICF b2401, b280, b4301 and b440 domains on the values of air temperature (AT-M), atmospheric pressure variability (APV), air temperature variability (ATV-M) wind speed (WS-M) and total CIPP-M have been developed, which allow to reliably form a rehabilitation prognosis for patients with IHD for all terms of health resort treatment in the SCC.Conclusions. The use of modernized clinical indices of weather pathogenicity allows one to adequately assess and predict the effect of weather dynamics and form a rehabilitation prognosis for patients with IHD.
ADVANCE research 20 years later
Authors: Kobalava Zh. D. , Kolesnik E. L. 
Published: September 2021

Observational and interventional studies have shown that intensive blood pressure control may benefit in patients with diabetes. The Action in Diabetes and Vascular Disease: Preterax and Diarnicron MR Controlled Evaluation (ADVANCE) international randomized, controlled, clinical trial was launched in 2001. According to the results of the study, the risk of major micro- and macrovascular events (primary endpoint) significantly decreased by 9%, while the risks of cardiovascular death and death from any cause decreased by 18% and 14%, respectively. There was a decrease in the risks of microvascular complications – any renal event, the appearance or worsening of nephropathy and the appearance of microalbuminuria by 21%, 18% and 21%, respectively. The results of the antihypertensive part of the ADVANCE study supplemented the expanding evidence base and served as the basis for changing clinical guidelines for the management of patients with hypertension and diabetes. According to the updated joint guidelines of the European Society of Cardiology / European Association for the Study of Diabetes (ESC/EASD), the target systolic / diastolic blood pressure levels should be 130/80 mmHg, with some exceptions, and the fixed combination of the RAAS blocker with a diuretic or calcium antagonist is suggested as first-line therapy.The observational ADVANCE-ON study, which enrolled 8494 patients out of 11 140 patients randomized to the ADVANCE study, found a memory effect, or ‘inheritance’, in which intensive blood pressure control during the study had a beneficial effect on various outcomes after its termination. These findings highlight the importance of achieving and maintaining optimal blood pressure control to reduce the risk of micro- and macrovascular complications.
The influence of geomagnetic and seismic parameters on mortality from cardiovascular pathologies in the Shamakhi Region of the Republic of Azerbaijan
Authors: Afandieva L. G. 
Published: September 2021

Aim. Study of the dependence of mortality from CVD on helio-seismic indicators in the Shamakhi region of the Republic of Azerbaijan.Materials and methods. 352 case histories of patients who died in 2013 from various diseases were reviewed. The relationship was established between the number of deaths, their causes, distribution by sex and age with the magnitude of earthquakes, the depth of the epicenter and seismological activity by months. The data obtained were statistically processed using the Statistica 12.0 for Windows software package (Statsoft Inc., USA). To establish correlations, Pearson Chi-Square Tests was calculated, the results were considered reliable at p <0.05.Results. Statistically significant (p <0.001) more deaths were observed at the age of 80-89 years in men, and at the age of 70-79 years in women. Also, the relationship between mortality and the depth of the seismic process and the magnitude of the earthquake was established, in particular, the greatest number of deaths was observed at a depth of the seismic process <10 km and with a magnitude of 1.1-2.0 ml. In all months, the number of deaths was higher with a magnitude of 1.1-2.0 Ml. Statistically significant (p <0.005) was the fact that the nosology of the studied diseases was dependent on the age of the patients. Thus, a greater number of deaths in all age groups accounted for heart failure. A statistically significant (p <0.005) dependence of the depth of the seismic process on the month of death of patients was established, in particular, for all months, deaths coincided with the depth of the process less than 10 km. At the age of 40-70 years, a significantly greater number of deaths were from heart failure in men, and from 70 years and above in women.Conclusion. Thus, there is a close correlation between geomagnetic changes and mortality from CVD, which is realized in the form of an increase in the frequency of cases and deaths, and the number of these cases increases with the age of patients and changes in the magnitude and depth of the earthquake.
Sec22b Regulates Inflammatory Responses by Controlling the Nuclear Translocation of NF-κB and the Secretion of Inflammatory Mediators
Authors: Arango Duque Guillermo , Dion Renaud , Matte Christine , Fabié Aymeric , Descoteaux Julien , Stäger Simona , Descoteaux Albert 
Published: September 2021

Abstract
Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) regulate the vesicle transport machinery in phagocytic cells. Within the secretory pathway, Sec22b is an endoplasmic reticulum–Golgi intermediate compartment (ERGIC)-resident SNARE that controls phagosome maturation and function in macrophages and dendritic cells. The secretory pathway controls the release of cytokines and may also impact the secretion of NO, which is synthesized by the Golgi-active inducible NO synthase (iNOS). Whether ERGIC SNARE Sec22b controls NO and cytokine secretion is unknown. Using murine bone marrow-derived dendritic cells, we demonstrated that inducible NO synthase colocalizes with ERGIC/Golgi markers, notably Sec22b and its partner syntaxin 5, in the cytoplasm and at the phagosome. Pharmacological blockade of the secretory pathway hindered NO and cytokine release, and inhibited NF-κB translocation to the nucleus. Importantly, RNA interference–mediated silencing of Sec22b revealed that NO and cytokine production were abrogated at the protein and mRNA levels. This correlated with reduced nuclear translocation of NF-κB. We also found that Sec22b co-occurs with NF-κB in both the cytoplasm and nucleus, pointing to a role for this SNARE in the shuttling of NF-κB. Collectively, our data unveiled a novel function for the ERGIC/Golgi, and its resident SNARE Sec22b, in the production and release of inflammatory mediators.
Down Syndrome Cell Adhesion Molecule Triggers Membrane-to-Nucleus Signaling–Regulated Hemocyte Proliferation against Bacterial Infection in Invertebrates
Authors: Li Hao , Jin Xing-Kun , Zhou Kai-Min , Zhao Hui , Zhao Yue-Hong , Wang Qun , Li Wei-Wei 
Published: September 2021

Abstract
Down syndrome cell adhesion molecule (Dscam) generates tens of thousands of isoforms by alternative splicing, thereby providing crucial functions during immune responses. In this study, a novel Dscam signaling pathway was investigated in crab, which remains poorly characterized in invertebrates. Bacterial infection induced the cytoplasmic cleavage of Dscam intracellular domains (ICDs) by γ-secretase, and then the released ICDs carrying specific alternatively spliced exons could directly interact with IPO5 to facilitate nuclear translocation. Nuclear imported ICDs thus promoted hemocyte proliferation and protect the host from bacterial infection. Protein-interaction studies revealed that the ectodomain of Dscam bound to a disintegrin and metalloprotease domain 10 (ADAM10) rather than ADAM17. Inhibition or overexpression of ADAM10 impaired or accelerated Dscam shedding activity post–bacterial stimulation, respectively. Moreover, the shedding signal then mediated Dscam with an intact cytoplasmic domain to promote the cleavage of ICDs by γ-secretase. Furthermore, the transcription of ADAM10 was regulated by Dscam-induced canonical signaling, but not nuclear imported ICDs, to serve as a feedback regulation between two different Dscam pathways. Thus, membrane-to-nuclear signaling of Dscam regulated hemocyte proliferation in response to bacterial infection.
Substitution of Local Indonesian Varieties of Brown Rice on Anthropometry and Blood Glucose Level Improvement in type 2 DM Patients: A Pilot Project
Authors: Handayani Dian , Kusumastuty Inggita , Inayah Alma Maghfirotun , Retnaningtyas Ekowati , Sulistyowati Etik , Sasiarini Laksmi , Rudijanto Achmad 
Published: September 2021

Background Diabetes mellitus (DM) is a metabolic disorder whose prevalence increases globally. Medical nutrition therapy (MNT) is one of the DM management pillars to control blood glucose. Local Indonesian brown rice is proven to contain high fiber and magnesium levels thus could improve obesity, fasting blood glucose, and HbA1c. This study aims to prove the benefits of brown rice on anthropometric parameters and blood glucose control. Design and methods Respondents were overweight women older than 40 years with type 2 diabetes who were given three main meals and three snacks six days a week for 12 weeks. Anthropometric and blood glucose control data were collected before and after the intervention. Diet and intake data before the intervention were obtained through a semi quantitate food frequency questionnaire. Intake data during the intervention were recorded using the 24-hour food record and analyzed using modified NutriSurvey 2007 software. Results Brown rice intervention significantly reduced body weight, BMI, body fat percentage, and abdominal circumference (p<0.05), also in fasting blood glucose (FBG), 2-h postprandial blood glucose (PBG), and HbA1c (p<0.05). From the Pearson's test results, an increase in fiber intake correlated with a decrease in BMI and abdominal circumference (p=0.03; r = -0.511 and p=0.006; r = -0.619, respectively). Meanwhile, magnesium intake and changes in BMI showed a negative correlation. Conclusions The substitution of brown rice as a staple food for 12 weeks improves anthropometric parameters and blood glucose control in respondents with type 2 diabetes.
Utility of Transcranial Magnetic Stimulation and Diffusion Tensor Imaging for Prediction of Upper-Limb Motor Recovery in Acute Ischemic Stroke Patients
Authors: Kumar Pradeep , Prasad Manya , Das Animesh , Vibha Deepti , Garg Ajay , Goyal Vinay , Srivastava Achal K. 
Published: September 2021

Background:
The recovery of the upper-limb (UL) motor function after ischemic stroke (IS) remains a major scientific, clinical, and patient concern and it is hard to predict alone from the clinical symptoms.

Objective:
To determine the accuracy of the prediction of the recovery of UL motor function in patients with acute ischemic middle cerebral artery (MCA) stroke using individual clinical, transcranial magnetic stimulation (TMS) or diffusion tensor imaging (DTI) parameters or their combination.

Methods and Material:
The first-ever acute ischemic MCA stroke patients within 7 days of the stroke onset who had an obvious UL motor deficit underwent TMS for the presence of motor-evoked potential (MEP) and DTI to evaluate the integrity of corticospinal tracts. Multivariate logistic regression analysis was done to test for the accuracy of the prediction of the recovery of UL motor function.

Results:
Twenty-nine acute ischemic MCA stroke patients (21 males and 8 females) with a mean age of 51.45 ± 14.26 years were recruited. Model-I included clinical scales (Fugl-Meyer Assessment [FMA] + Motricity Index [MI]) + TMS (MEP) + DTI (fractional anisotropy [FA]) were found to be the most accurate predictive model, with the overall predictive ability (93.3%; 95% confidence interval [CI]: 0.87–0.99) and sensitivity: 94.9% (95% CI: 0.87–1.0) and specificity: 95.8% (95% CI: 0.89–1.0); respectively.

Conclusion:
The accuracy of UL motor recovery can be predicted through the clinical battery and their elements as well as TMS (MEP) and DTI (FA) parameters. Further, well-designed prospective studies are needed to confirm our findings.
Evaluation of Barrett Universal II, SRK-T, and Haigis formulae for intraocular lens power calculation in myopes using optical biometry
Authors: Aziz Demiana W. , Osman Moataz H. , Hassan Nihal A. , Bahgat Nermeen M. 
Published: September 2021

Objective
To assess the precision of Barrett Universal II, SRK-T, and Haigis formulas in high myopic eyes for the estimation of intraocular lens power, using optical biometry.

Patients and methods
This is an interventional prospective study that included 34 eyes with an axial length more than or equal to 26 mm, who underwent uneventful phacoemulsification. One month after the surgery, we recorded the postoperative refraction. Refractive prediction error (RPE), median absolute error (Med AE), and proportion of eyes with postoperative myopic and hyperopic outcomes were compared.

Results
The lowest mean RPE (−0.11±0.90 D), Med AE (0.15 D), and proportion of eyes with hyperopic outcomes (44.1%) were reported with the Barrett Universal II formula. They were all statistically lower than the results of SKR/T and Haigis formulas (mean RPE 0.16±0.99 and 0.31±0.98 D, respectively; Med AE 0.47 and 0.40 D, respectively; and percentage of hyperopic outcome 70.6 and 76.5%, respectively).

Conclusion
We concluded that the lowest mean RPE, median AE, and the lowest percentage of hyperopic outcome were reported with the Barrett Universal II formula.
Assessment of outcomes of a hospital-based tobacco cessation intervention program
Authors: Torwane Nilesh Arjun , Dayma Ashwini , Hongal Sudheer , Ahire (Torwane) Priyanka Anil 
Published: September 2021

Background:
Tobacco use among adult Indian population is 34.6% by Global adult tobacco survey (2016–2017) reported 6.8 crores urban, 19.9 crores rural Indians are tobacco consumers. M. P state fact file declares highest tobacco consumers residing in Madhya Pradesh.

Methodology:
The current study is an individual as well as community-based tobacco intervention program, to evaluate the trends of tobacco use, awareness related to tobacco hazard, quit tobacco regime, withdrawal, relapse in post intervention follow-up.

Results:
In the total regime of 3 months starting from detox groundwork of body for cessation to behavior modification, phase of nicotine replacement therapy (NRT) to pharmacological intervention at spaced out follow-up the graph gradually declined down of individuals positively motivated for quitting.

Conclusion:
Tobacco cessation (quitting) with behavior modification, NRT, and Pharmacological mode is a relatively novel approach of tobacco control in India. It is considered to be the most cost-effective intervention as compared to other tobacco control programs and other approaches of reducing tobacco menace.
Comparison of the influx of bacterial-sized particles in single plane versus multiplane femtosecond laser incisions
Authors: May William , Al Mutlak Mohammed , Aalam Waseem , Rashidi Sultan , Khandekar Rajiv 
Published: September 2021

Purpose:
To present ingress of dye particles that are of size of bacteria though single and multi-planar corneal incision created by femtosecond laser in donor eyes.

Setting:
A tertiary eye Hospital, Central Saudi Arabia.

Design:

Ex vivo experimental study.

Methods:
This ”as ex vivo experimental study. Eyes acquired from an eye-bank that ”ere deemed unsuitable for corneal transplant ”ere used to create single as ”ell as multi-planar corneal incision using LenSx femtosecond laser. Each eye received single plane (SP) and one of the multiplanes either default multi-planar (DMP) or a right-angled multi-planar (RAMP) incision. After maintaining intraocular pressure (IOP), India ink ”as placed on the ”ound. Length and ”idth of ingress dye ”ere photographed and measured for different types of ”ound.

Results:
A total of 10 eyes ”ere used for this experiment. At physiologic IOP, the median and 25% quartile of length”ise invasion ”as 0.29 mm for the SP group (10 eyes), 0.23 mm for the DMP group (5 eyes), and 0.22 mm for the RAMP group (5 eyes). The difference of ingress bet”een the SP and RAMP groups as ”ell as SP and DMP group ”ere statistically significant (P = 0.005). The difference in length”ise and area ”ise invasion bet”een the DMP and RAMP groups ”as not statistically significant (P = 0.5).

Conclusion:
Bacteria size particle ingress seems to be more likely through SP incision compared to multi-plane corneal incisions created ”ith a femtosecond laser.
Inflamed pedunculated giant molluscum contagiosum of eyelid in an immunocompetent child
Authors: Surya Divyalakshmi Kaiyoor , Arunachalam Cynthia 
Published: September 2021

Molluscum contagiosum (MC) is a skin infection caused by a member of the Poxvirus family. It typically affects young or immunocompromised individuals.[1]. Lesions are localised localized on the face, arms, legs, and anogenital region. Typically, it presents as single or multiple umbilicated papules or nodules on the skin and eyelid margin and conjunctiva.[2] There are very few reports of giant molluscum presenting as an inflammatory lesion in an immunocompetent patient. Here, we are presenting a case of solitary giant MCmolluscum contagiosum presenting like an inflamed pedunculated mass of eyelid in an immunocompetent child.
A one 1½and half -year- old immunocompetent child presented with an inflamed large umbilicated lesion in upper eyelid which was excised in toto. Excision revealed a gyriform lesion and histopathologic confirmation was done.
Risk factors for thyroid-associated orbitopathy due to Graves' disease
Authors: Nabi Tauseef , Rafiq Nadeema , Dar Imtiyaz Ahmad 
Published: September 2021

Background:
Thyroid-associated orbitopathy (TAO) is the principal extrathyroidal manifestation of Graves' disease (GD). TAO is described as chronic inflammation of orbital and periorbital tissue. Environmental risk factors variably influence the development of TAO and risk factors vary with ethnicity and geographical region.

Aims:
To evaluate the clinical factors for TAO in patients with GD.

Setting and Design:
This was a hospital-based cross-sectional study done on consecutive 76 newly diagnosed patients of GD documented by thyroid 99mtechnetium-pertechnetate scan.

Materials and Methods:
Patients were subjected to a complete clinical workup and thyroid profile. The diagnosis of TAO was based on the criteria of Bartley and Gorman. Fifty-two TAO patients were compared with 24 non-TAO patients (controls) for risk.

Statistical Analysis Used:
All analyses were performed using SPSS software (version 21.0).

Results:
TAO was present in 52 (68%) of patients with GD. TAO was bilateral in 50 (96%) patients. Majority of the patients had mild orbitopathy (34, 65.4%) and none of the patients showed any signs of sight-threatening disease. Clinical activity score was active in 13.5% of the study group. There was significant female preponderance in TAO. Current smoking increased the risk of TAO (P = 0.023). Total triiodothyronine (T3) and mean intraocular pressure (IOP) in primary and upward gaze were significantly elevated at baseline in TAO patients. Braley's sign was seen in 30.7% of patients with TAO and in 8.3% of patients in the control group (P = 0.033). Current smoking, total T3 >4 ng/dl, and differential IOP >6 mmHg were found to be associated with the risk of TAO.

Conclusion:
TAO was clinically inactive and of mild severity in most cases. This study identified current smoking, total T3 >4 ng/dl, and differential IOP > 6mmHg as risk factors for TAO.