bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of pre-exposure prophylaxis programme in Spain. Feasibility of four different delivery models
Authors: Iniesta Carlos , Coll Pep , Barberá María Jesús , García Deltoro Miguel , Camino Xabier , Fagúndez Gabriela , Díaz Asunción , Polo Rosa ,   Spanish Working Group for PrEP
Published: February 2021

Background
Pre-exposure prophylaxis (PrEP) is an effective and cost-effective strategy for HIV prevention. Spain carried out an implementation study in order to assess the feasibility of implementing PrEP programmes within its heterogeneous health system.

Methods
Observational longitudinal study conducted on four different types of health-care setting: a community centre (CC), a sexually transmitted infections clinic (STIC), a hospital-based HIV unit (HBHIVU) and a hospital-based STI unit (HBSTIU). We recruited gay, bisexual and other men who have sex with men (GBSM) and transgender women at risk of HIV infections, gave them PrEP and monitored clinical, behavioural PrEP-related and satisfaction information for 52 weeks. We collected perceptions on PrEP implementation feasibility from health-care professionals participating in the study.

Results
A total of 321 participants were recruited, with 99.1% being GBMSM. Overall retention was 87.2% and it was highest at the CC (92.6%). Condom use decreased during the study period, while STIs did not increase consistently. The percentage of people who did not miss any doses of PrEP during the previous week remained at over 93%. No HIV seroconversions occurred. We observed overall decreases in GHB (32.5% to 21.8%), cocaine (27.5% to 21.4%), MDMA (25.7% to 14.3%), speed (11.4% to 5.7%) and mephedrone use (10.7% to 5.0%). The overall participant satisfaction with PrEP was 98.6%. Health-care professionals’ perceptions of PrEP feasibility were positive, except for the lack of personnel.

Conclusions
PrEP implementation is feasible in four types of health-care settings. Local specificities have to be taken into consideration while implementing PrEP.
Factors affecting outcome of longer regimen multidrug-resistant tuberculosis treatment in West Java Indonesia: A retrospective cohort study
Authors: Soeroto Arto Yuwono , Pratiwi Chica , Santoso Prayudi , Lestari Bony Wiem 
Published: February 2021

Background
Multidrug-resistant tuberculosis had high treatment failure and mortality. Success rate of treatment currently 56% at global level, 48% in Indonesia and 36% in West Java province, the most populated province and surround Jakarta, the capitol of Indonesia.

Objective
This study aimed to evaluate factors affecting success of multidrug-resistant tuberculosis treatment in patients using longer treatment regimen in West Java Indonesia.

Methods
This was a retrospective cohort study of multidrug-resistant tuberculosis patients treated with longer regimen at Hasan Sadikin General Hospital from January 2015 to December 2017. Potential risk factors associated with the treatment outcome were analyzed using multiple logistic regression.

Results
A total of 492 patients were enrolled during the study period. Fifty percents multidrug-resistant tuberculosis patients had successful treatment outcome. Age ≤45 years, male, normal body mass index, no previous tuberculosis treatment, culture conversion ≤2 months, acid fast bacilli sputum smear ≤+1 were independent factors associated with increased treatment success. Sputum culture conversion ≤2 months was the major factor affecting successful outcome (RR 2.79; 95% CI: 1.61–4.84; p-value<0.001). Human Immunodeficiency Virus infection, chronic kidney disease, and cavitary lesion were independent risk factors for unfavourable outcome.

Conclusion
Age, gender, body mass index, tuberculosis treatment history, time of sputum conversion, acid fast bacilli sputum smear, HIV infection, chronic kidney disease, and cavitary lesion can be used as predictors for longer multidrug-resistant tuberculosis treatment regimen outcome.
Ambulatory anal self-sampling in MSM living with HIV, an acceptable and reliable screening method
Authors: Heid-Picard Benoît , Cochand-Priollet Béatrix , Rozenberg Flore , Giang-Phang David , Viard Jean-Paul , La Torre Valentina , Ghosn Jade 
Published: February 2021

Objectives
Anal cancer, usually driven by an oncogenic Human Papillomavirus, remains a leading cause of morbidity in men who have sex with men (MSM) living with HIV, despite combined antiretroviral therapy. Various recommendations advocate to perform regular examination and proctologist-performed samples to anticipate this risk and treat locally before cancer occurrence, an efficient strategy which has the drawback of requiring the proctologist’s availability. This study evaluates the acceptability, feasibility, and efficiency of self-performed samples to screen for HPV-infection and HPV-related anal dysplasia among MSM living with HIV followed in Hôtel-Dieu Hospital.

Methods
Between February 2015 and June 2015, MSM living with HIV and referred to the day-care hospital were offered to perform an anal self-sampling for cytologic and virologic evaluation. A self-sampling kit was provided, and a tutorial video was shown. A subset of participants had a proctology appointment after they did the self-sampling, and thus had a clinical examination and an anal swab sampling performed by the proctologist, using the same sampling material.

Results
Anal self-sampling was offered to 103 patients, and 100 accepted. Sixty-three samples were interpretable, of which 36 (57%) were normal and 27 (43%) showed abnormal results. Virologic analysis was performed for 60 (95%) interpretable samples: 50/60 (83%) of them were positive for HPV. Among HPV-carrier patients, 42/50 (84%) were infected with at least one HR-HPV. Twenty patients had a proctologist consultation. All clinician-performed samples were interpretable and 14 (70%) self-samples were interpretable.

Conclusions
This study highlights the acceptable accuracy of self-sampling screening method among MSM living with HIV and try out its acceptability and feasibility as a secondary prevention device. Although it cannot replace a proctologist consultation for high risk patients, self-sampling should be studied further as one of the ways of screening for anal cancer among low-risk outpatients.
Comparative efficacy and safety of statin and fibrate monotherapy: A systematic review and meta-analysis of head-to-head randomized controlled trials
Authors: Blais Joseph E. , Tong Gloria Kin Yi , Pathadka Swathi , Mok Michael , Wong Ian C. K. , Chan Esther W. 
Published: February 2021

Objective
To assess whether in adults with dyslipidemia, statins reduce cardiovascular events, mortality, and adverse effects when compared to fibrates.

Methods
Systematic review and meta-analysis of head-to-head randomized trials of statin and fibrate monotherapy. MEDLINE, EMBASE, Cochrane, WHO International Controlled Trials Registry Platform, and ClinicalTrials.gov were searched through October 30, 2019. Trials that had a follow-up of at least 28 days, and reported mortality or a cardiovascular outcome of interest were eligible for inclusion. Efficacy outcomes were cardiovascular mortality and major cardiovascular events. Safety outcomes included myalgia, serious adverse effects, elevated serum creatinine, and elevated serum alanine aminotransferase. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using the Mantel-Haenszel fixed-effect model, and heterogeneity was assessed using the I2 statistic.

Results
We included 19 eligible trials that directly compared statin and fibrate monotherapy and reported mortality or a cardiovascular event. Studies had a limited duration of follow-up (range 10 weeks to 2 years). We did not find any evidence of a difference between statins and fibrates for cardiovascular mortality (OR 2.35, 95% CI 0.94–5.86, I2 = 0%; ten studies, n = 2657; low certainty), major cardiovascular events (OR 1.15, 95% CI 0.80–1.65, I2 = 13%; 19 studies, n = 7619; low certainty), and myalgia (OR 1.32, 95% CI 0.95–1.83, I2 = 0%; ten studies, n = 6090; low certainty). Statins had less serious adverse effects (OR 0.57, 95% CI 0.36–0.91, I2 = 0%; nine studies, n = 3749; moderate certainty), less elevations in serum creatinine (OR 0.17, 95% CI 0.08–0.36, I2 = 0%; six studies, n = 2553; high certainty), and more elevations in alanine aminotransferase (OR 1.43, 95% CI 1.03–1.99, I2 = 44%; seven studies, n = 5225; low certainty).

Conclusions
The eligible randomized trials of statins versus fibrates were designed to assess short-term lipid outcomes, making it difficult to have certainty about the direct comparative effect on cardiovascular outcomes and mortality. With the exception of myalgia, use of a statin appeared to have a lower incidence of adverse effects compared to use of a fibrate.
Positive Fecal Immunochemical Test Strongly Predicts Adenomas in Younger Adults With Fatty Liver and Metabolic Syndrome
Authors: Yeh Jen-Hao , Lin Chih-Wen , Wang Wen-Lun , Lee Ching-Tai , Chen Jen-Chieh , Hsu Chia-Chang , Wang Jaw-Yuan 
Published: February 2021

INTRODUCTION:
The incidence of early-onset colorectal cancer is increasing. This study explored the feasibility of fecal immunochemical test (FIT) and risk factors for predicting colorectal neoplasm in younger adults.

METHODS:
This single-center study included 6,457 participants who underwent health examination from 2013 to 2016 including index colonoscopy (3,307 individuals aged 30–49 years as the younger adult group and 3,150 aged ≥50 years as the average-risk group). Primary outcomes were adenoma detection rate (ADR) and advanced ADR (AADR). Findings of younger participants were stratified by the results of FIT and clinical risk factors and were compared with those of the average-risk group.

RESULTS:
Among participants aged 30–49 years, a positive FIT was associated with significantly higher ADR (28.5% vs 15.5, P < 0.001) and AADR (14.5% vs 3.7%, P < 0.001) than a negative FIT. Moreover, a positive FIT was associated with higher AADR in younger participants than in average-risk counterparts (14.5% vs 9.8%, P = 0.028). Although no single risk factor predicted FIT positivity in younger participants, nonalcoholic fatty liver disease was independently associated with higher ADR (odds ratio = 2.60, 95% confidence interval = 1.27–5.34, P = 0.001), and metabolic syndrome was independently predictive of higher AADR in younger participants than in average-risk participants (odds ratio = 3.46, 95% confidence interval = 1.66–7.21, P = 0.001).

DISCUSSION:
A positive FIT in people aged 30–49 years implies a higher risk of colorectal neoplasm, particularly among patients with nonalcoholic fatty liver disease and metabolic syndrome.
Influence of amount of pesticide and amount of PPE to diastolic blood pressure of farmers in Bumen Village, Sumowono District, Semarang Regency
Authors: Kurnia Sari Atka , Joko Tri , Yunita Dewanti Nikie Astorina 
Published: February 2021

Background: Farmers in Bumen Village used pesticide from group of organophospat, carbamate, piretroid, and nicotinoid. The dose of pesticide that mix in one tank is not appropriate dosage. A preliminary survey found that farmers mixed more than a two types of pesticides and 100% of farmers did not use the complete Personal Protective Equipment (PPE) when preparing pesticides to spray. Hypertension is more prevalent in males with an 18.8% prevalence in Sumowono District in 2015 and becomes the number one disease each month in 2017. The purpose of this study was to determine the influence of the amount of pesticide and the amount of PPE with diastolic blood pressure in farmers in Bumen Village, Sumowono District, Semarang Regency. Independent variables were amount of pesticide and amount of PPE. Dependent variable was diastolic blood pressure.Methods: This study was observational with cross sectional design using purposive sampling. Samples were 35 respondents. The measurement methods were questionnaire and digital tensimeter. Data analysis used Rank Spearman.Results: The results showed that measurement of diastolic blood pressure has an average of 88.75 mmHg. The amount of pesticide (p=0,007; r=0,455) had an influence with diastolic blood pressure, positive correlation, the strenght of correlation was enough and the amount of PPE (p=0,034; r=-0,36) had an influence with diastolic blood pressure, negative correlation, the strenght of correlation was enoughConclusions: From this study can be concluded that the amount of pesticide and the amount of PPE affected the diastolic blood pressure in farmers in Bumen Village, Sumowono District, Semarang Regency.
The Social Meaning Potential of the Global English Based on Data from Different Communities
Authors: Vaicekauskienė Loreta 
Published: February 2021

This paper describes the social value of the global English language as identified in the investigations of various communities worldwide and shows how the social meanings of English relate to each other in a broader ideological field universal for today’s locally global world. The notions of indexical field (Eckert 2008) and bivalent indexicality (Cotter, Valentinsson 2018) are applied in the analysis. The aim of the study is to synthesize results obtained by different researchers from different ideological and communicative contexts and to explore the indexical potential of English, including its local varieties and mixed speech styles. The study is based on a qualitative analysis of a corpus of secondary sources, consisting of a total of 74 scholarly publications from the Expanding Circle communities, which were published in English in 1990–2020 (most of them during the second decade of the 21st century).In total, more than 50 social meanings of the global English language have been identified. It is likely that the abundance of social associations with English is due to the strong first-order indexes. Hence, the social meanings were grouped into the following nine indexical categories based on the presumed first-order sociocultural indexicalities: British and American culture; International sphere; Technologies, science and education; Economic and social status; Personal capital; Youth; Popular culture and media; Urban sphere; and Male. Positive social meanings dominate the indexicalities, but for some of them, bivalent indexicality (presence of contradictory positive and negative values) has been recorded. Although there is much overlap between these relative categories, the constellation as a whole is interpreted as a complex of several separate and multivalent indexical fields. It is to be hoped that this study not only illustrates that the notion of indexical field is applicable for analysis of the imagined global community of users of English, but also provides a broader ideological context for further research of the social meaning-making potential of the global English language.
Integration of satellite data processing with seismic sections for tectonic interpretation and modeling for the breaks and omissions of continuous stratigraphic units
Authors: Thannoun Rayan Gh. , Fanoosh Salim A. , Adeeb Hadeer Gh. M. 
Published: February 2021

AbstractSatellite thematic maps in geological field studies are an important tool for the delineation, interpretation, representation, and visualization of geological processes, while the development of seismic sections offers an increasingly detailed analysis of subsurface geology and inferring and understanding the subsurface structure of the earth. This combination promoted a fast-growing research in the fields of morphotectonics and neotectonics. The area under investigation is one of the most significant Iraqi places which includes several oil fields. The study area is located in northern Iraq and administratively follows Kirkuk governorate. Landscapes in this area are characterized by asymmetrical, cylindrical and extended folds. Kirkuk, Bai-Hasan and Qarachuq Anticlines reflect these structural elements and their fold axis trends towards northwest-southeast within the Zagros folded zone. The main objective of this study is to use the visual and digital interpretation of Landsat image to discriminate the sudden breaks and omissions of rock beds in the study area. Therefore, a morphotectonic map was created, the accurate location of the sudden breaks was provided and the zones affected by tectonic deformation, which left its imprint on the successive lithological units were detected. Seismic data were used to assess the tectonic impact on subsurface formations and their reflections on exposure rocks. The seismic lines were selected based on the locations of the identified sudden breaks as interpreted from satellite images. The hypothesis derived from this study is that the sudden breaks in the study area were triggered by a series of faults. In addition, the region was affected by the vertical stresses resulting from these faults and morphological aspects of the region were determined by the temporal variations of the above stresses.
Application of the eleventh revision of the International Classification of Diseases gaming disorder criteria to treatment-seeking patients: Comparison with the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders Internet gaming disorder criteria
Authors: Higuchi Susumu , Nakayama Hideki , Matsuzaki Takanobu , Mihara Satoko , Kitayuguchi Takashi 
Published: February 2021

AbstractBackground and aimsThe World Health Organization included gaming disorder (GD) in the eleventh revision of International Classification of Diseases in 2019. Due to the lack of diagnostic tools for GD, a definition has not been adequately applied. Therefore, this study aimed to apply an operationalized definition of GD to treatment-seekers. The relationship between the diagnoses of GD and Internet gaming disorder (IGD) in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders was also examined. Methods: Study participants comprised 241 treatment-seekers who had engaged in excessive gaming and experienced related problems. Psychiatrists applied the GD diagnostic criteria to the participants using a diagnostic form developed for this study. Information on gaming behavior and functional impairment was obtained through face-to-face interviews conducted by clinical psychologists. Results: In total, 78.4 and 83.0% of the participants fulfilled the GD and IGD diagnostic criteria, respectively. The sensitivity and specificity of GD diagnosis were both high when the IGD diagnosis was used as the gold standard. Participants with GD preferred online PC and console games, spent significantly more time gaming, and showed a higher level of functional impairment compared to those who did not fulfill the GD diagnostic criteria. Discussion and Conclusion: The definition of GD can be successfully applied to treatment-seekers with excessive gaming and related problems. A high concordance of GD and IGD diagnoses was found in those participants with relatively severe symptoms. The development and validation of a diagnostic tool for GD should be explored in future studies.
A randomized prospective study to compare the efficacy and safety of budesonide plus formoterol and tiotropium plus formoterol in patients having mild to moderate chronic obstructive pulmonary disease
Authors: Singh Chandra Veer , Gautam Aditya Kumar , Dixit Alok , Singh Amit Vikram , Singh Sandeep Kumar 
Published: February 2021

Background: Chronic obstructive pulmonary disease (COPD) is a leading respiratory illness affecting the quality of lives around the world. The present study aims to compare the efficacy and safety of combination of inhaled corticosteroid (ICS) and long acting β2 agonist (LABA) with long acting β2 agonist and long acting muscarinic antagonist (LAMA) in treatment of mild to moderate COPD in a tertiary care hospital.Methods: Total 132 patients with COPD were recruited on the basis of inclusion and exclusion criteria for 8 weeks study from outpatient clinic. A complete pulmonary examination including spirometry examination was done to rule out severe and very severe forms of COPD. Spirometry was performed at the time of recruitment for evaluation of forced expiratory volume in one second (FEV1) and measurement of SpO2 at the time of recruitment at 2 weeks and 8 weeks. Appropriate statistical methods were used to compare the qualitative and quantitative primary and secondary efficacy end points, p value <0.05 was considered significant.Results: On analysis, there was a significant difference (p<0.05) was observed in FEV1 and SpO2 from baseline in ICS plus LABA group (n=66). A similarly significant difference (p<0.05) was observed in LABA and LAMA group (n=66). On comparison between ICS plus LABA and LABA plus LAMA no significant difference in FEV1 and SpO2 was observed between the two groups. More adverse drug reactions were observed in ICS plus LABA group than LAMA plus LABA group.Conclusions: Combination of ICS and LABA combination is as effective as combination of LABA and LAMA in patients having mild to moderate COPD. However, LABA and LAMA combination is preferable because it is associated with fewer side effects.
Effects of a national policy advocating rational drug use on decreases in outpatient antibiotic prescribing rates in Thailand
Authors: Waleekhachonloet Onanong , Rattanachotphanit Thananan , Limwattananon Chulaporn , Thammatacharee Noppakun , Limwattananon Supon 
Published: February 2021

Objective: This study examined the effects of a national policy advocating rational drug use (RDU), namely, the ‘RDU Service Plan’, starting in fiscal year 2017 and implemented by the Thai Ministry of Public Health (MOPH), on trends in antibiotic prescribing rates for outpatients. The policy was implemented subsequent to a voluntary campaign involving 136 hospitals, namely, the ‘RDU Hospital Project’, which was implemented during fiscal years 2014-2016.
Methods: Hospital-level antibiotic prescribing rates in fiscal years 2014-2019 for respiratory infections, acute diarrhea, and fresh wounds were aggregated for two hospital groups using equally weighted averages: early adopters of RDU activities through the RDU Hospital Project and late adopters under the RDU Service Plan. Pre-/post-policy annual changes in the prescribing levels and trends were compared between the two groups using an interrupted time-series analysis.
Results: In fiscal years 2014-2016, decreases in antibiotic prescribing rates for respiratory infections and acute diarrhea in both groups reflected a trend that existed before the RDU Service Plan was implemented. The immediate effect of the RDU Service Plan policy occurred in fiscal year 2017, when the prescribing level among the late adopters dropped abruptly for all three conditions with a greater magnitude than in the decrease among the early adopters, despite nonsignificant differences. The medium-term effect of the RDU Service Plan was identified through a further decreasing trend during fiscal years 2017-2019 for all conditions in both groups, except for acute diarrhea among the early adopters.
Conclusions: The national policy on rational drug use effectively reduced antibiotic prescribing for common but questionable outpatient conditions.