bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decision Science Can Inform Clinical Trade-Offs Regarding Cardiotoxic Cancer Treatments
Authors: Gillman Arielle S , Vo Jacqueline B , Nohria Anju , Ferrer Rebecca A 
Published: June 2021

Abstract
Cancer treatment-related cardiotoxicity (ie, heart failure, coronary artery disease, vascular diseases, arrhythmia) is a growing cancer survivorship concern within oncology practice; heart disease is the leading cause of noncancer death in cancer survivors and surpasses cancer as the leading cause of death for some cancers with higher survival rates. The issue of cardiotoxicity introduces a critical tradeoff that must be acknowledged and reconciled in clinical oncology practice: treating cancer aggressively and effectively in the present vs preventing future cardiotoxicity. Although many cancers must be treated as aggressively as possible, for others, multiple treatment options are available. Yet even when effective and less cardiotoxic treatments are available, they are not always chosen. Wariness to choose equally effective but less cardiotoxic treatment options may result in part from providers’ and patients’ reliance on “cognitive heuristics,” or mental shortcuts that people (including, research shows, medical professionals) use to simplify complex judgments. These heuristics include delay discounting, availability and affect heuristics, and default bias. In the current commentary, we describe relevant research that illuminates how use of heuristics leads to biased medical decision making and translate how this research may apply when the tradeoff between aggressive cancer treatment and preventing future cardiotoxicity is considered. We discuss the implications of these biases in oncology practice, offer potential solutions to reduce bias, and call for future research in this area.
Targeted metabolite profiling as a top-down approach to uncover interspecies diversity and identify key conserved operational features in the Calvin–Benson cycle
Authors: Stitt Mark , Luca Borghi Gian , Arrivault Stéphanie 
Published: June 2021

Abstract
Improving photosynthesis is a promising avenue to increase crop yield. This will be aided by better understanding of natural variance in photosynthesis. Profiling of Calvin–Benson cycle (CBC) metabolites provides a top-down strategy to uncover interspecies diversity in CBC operation. In a study of four C4 and five C3 species, principal components analysis separated C4 species from C3 species and also separated different C4 species. These separations were driven by metabolites that reflect known species differences in their biochemistry and pathways. Unexpectedly, there was also considerable diversity between the C3 species. Falling atmospheric CO2 and changing temperature, nitrogen, and water availability have driven evolution of C4 photosynthesis in multiple lineages. We propose that analogous selective pressures drove lineage-dependent evolution of the CBC in C3 species. Examples of species-dependent variation include differences in the balance between the CBC and the light reactions, and in the balance between regulated steps in the CBC. Metabolite profiles also reveal conserved features including inactivation of enzymes in low irradiance, and maintenance of CBC metabolites at relatively high levels in the absence of net CO2 fixation. These features may be important for photosynthetic efficiency in low light, fluctuating irradiance, and when stomata close due to low water availability.
Encoding the haunting of an object catalogue: on the potential of digital technologies to perpetuate or subvert the silence and bias of the early-modern archive
Authors: Ortolja-Baird Alexandra , Nyhan Julianne 
Published: June 2021

Abstract
The subjectivities that shape data collection and management have received extensive criticism, especially with regards to the digitization projects and digital archives of galleries, libraries, archives and museums (GLAM institutions). The role of digital methods for recovering data absences is increasingly receiving attention too. Conceptualizing the absence of non-hegemonic individuals from the catalogues of Sir Hans Sloane as an instance of textual haunting, this article will ask: to what extent do data-driven approaches further entrench archival absences and silences? Can digital approaches be used to highlight or recover absent data? This article will give a decisive overview of relevant literature and projects so as to examine how digital tools are being realigned to recover, or more modestly acknowledge, the vast, undocumented network of individuals who have been omitted from canonical histories. Drawing on the example of Sloane, this article will reiterate the importance of a more rigorous ethics of digital practice, and propose recommendations for the management and representation of historical data, so cultural heritage institutions and digital humanists may better inform users of the absences and subjectivities that shape digital datasets and archives. This article is built on a comprehensive survey of digital humanities’ current algorithmic approaches to absence and bias. It also presents reflections on how we, the authors, grappled with unforeseen questions of absence and bias during a Leverhulme-funded collaboration between the British Museum and University College London (UCL), entitled ‘Enlightenment Architectures: Sir Hans Sloane’s Catalogues of his collections’.
Rotational (de)-excitation of HMgNC in collision with He
Authors: Amor M A , Hammami K , Wiesenfeld L 
Published: June 2021

Abstract
Potential energy surface for the collision between HMgNC and He are evaluated using the high-accuracy CCSD(T)-F12 ab-initio method. This PES leads to conduct quantum dynamical scattering calculations of the rotational and hyperfine (de)-excitations rate coefficients for temperatures up to 200 K. In order to evaluate the impact of the computed data, we performed radiative transfer computations of the brightness and excitation temperatures for selected observed j = 8 to 7 transition.
Sensing and seeing associated with overlapping occipitoparietal activation in simultaneous EEG-fMRI
Authors: Scrivener Catriona L , Malik Asad , Lindner Michael , Roesch Etienne B 
Published: June 2021

AbstractThe presence of a change in a visual scene can influence brain activity and behavior, even in the absence of full conscious report. It may be possible for us to sense that such a change has occurred, even if we cannot specify exactly where or what it was. Despite existing evidence from electroencephalogram (EEG) and eye-tracking data, it is still unclear how this partial level of awareness relates to functional magnetic resonance imaging (fMRI) blood oxygen level dependent (BOLD) activation. Using EEG, fMRI, and a change blindness paradigm, we found multi-modal evidence to suggest that sensing a change is distinguishable from being blind to it. Specifically, trials during which participants could detect the presence of a colour change but not identify the location of the change (sense trials), were compared to those where participants could both detect and localise the change (localise or see trials), as well as change blind trials. In EEG, late parietal positivity and N2 amplitudes were larger for localised changes only, when compared to change blindness. However, ERP-informed fMRI analysis found no voxels with activation that significantly co-varied with fluctuations in single-trial late positivity amplitudes. In fMRI, a range of visual (BA17,18), parietal (BA7,40), and mid-brain (anterior cingulate, BA24) areas showed increased fMRI BOLD activation when a change was sensed, compared to change blindness. These visual and parietal areas are commonly implicated as the storage sites of visual working memory, and we therefore argue that sensing may not be explained by a lack of stored representation of the visual display. Both seeing and sensing a change were associated with an overlapping occipitoparietal network of activation when compared to blind trials, suggesting that the quality of the visual representation, rather than the lack of one, may result in partial awareness during the change blindness paradigm.
Predictors of survival in elderly patients undergoing surgery for glioblastoma
Authors: Voisin Mathew R , Sasikumar Sanskriti , Zadeh Gelareh 
Published: June 2021

Abstract

Background
Glioblastoma (GBM) has a median age of diagnosis of 64 years old and the incidence increases with age. An increasing number of elderly patients are being diagnosed with GBM and undergoing surgery. These patients often present with multiple medical comorbidities and have significantly worse outcomes compared to adult patients. The goal of this study was to determine clinical predictors of survival in elderly patients undergoing surgery for GBM.

Methods
Our brain tumor database was reviewed for all patients 65 years of age and older that underwent surgery for newly diagnosed GBM over a 14-year period from 2005 to 2018. Patient characteristics, comorbidities, complications, and treatment were collected. A total of 150 patients were included, and subdivided into two age categories; 65–74 years old and 75 years or older.

Results
The median OS for all patients was 9.4 months. Neither the presence nor number of medical comorbidities were associated with decreased survival (P = .9 and P = .1, respectively). Postoperative complications were associated with worse survival for all patients (HR = 2.34, P = .01) and occurred in patients in the older age category and patients with longer lengths of stay (P &lt; .0001).

Conclusions
The presence of medical comorbidities is not a reason to exclude patients with GBM from surgical consideration. Excluding EOR and adjuvant treatment, postoperative complication is the most significant predictor of survival in elderly patients. Postoperative complications are associated with a longer LOS and are more common in patients 75 years of age and older.
Relapsed Babesia microti Infection Following Allogeneic Hematopoietic Cell Transplantation in a Patient With B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature
Authors: Rosenblatt Joshua , Leung Annie , Baneman Emily , Fuller Risa , Taimur Sarah , Paniz-Mondolfi Alberto E , Malone Adriana K , Kirkman Laura , Jacobs Samantha E 
Published: June 2021

Abstract
A patient with relapsed/refractory B-cell acute lymphoblastic leukemia developed babesiosis before allogeneic hematopoietic cell transplantation while on atovaquone for Pneumocystis jirovecii pneumonia prophylaxis. Despite receiving a prolonged course of atovaquone and azithromycin until whole-blood Babesia microti DNA was no longer detected by polymerase chain reaction, her post-transplant course was complicated by relapsed babesiosis. We investigate the potential host and parasite characteristics causing relapsing/persistent infection.
Transmission of SARS-CoV-2 in Inpatient and Outpatient Settings in a Veterans Affairs Health Care System
Authors: Jinadatha Chetan , Jones Lucas D , Choi Hosoon , Chatterjee Piyali , Hwang Munok , Redmond Sarah N , Navas Maria E , Zabarsky Trina F , Bhullar Davinder , Cadnum Jennifer L , Donskey Curtis J 
Published: June 2021

Abstract

Background
Health care personnel and patients are at risk to acquire severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in health care settings, including in outpatient clinics and ancillary care areas.

Methods
Between May 1, 2020, and January 31, 2021, we identified clusters of 3 or more coronavirus disease 2019 (COVID-19) cases in which nosocomial transmission was suspected in a Veterans Affairs health care system. Asymptomatic employees and patients were tested for SARS-CoV-2 if they were identified as being at risk through contact tracing investigations; for 7 clusters, all personnel and/or patients in a shared work area were tested regardless of exposure history. Whole-genome sequencing was performed to determine the relatedness of SARS-CoV-2 samples from the clusters and from control employees and patients.

Results
Of 14 clusters investigated, 7 occurred in community-based outpatient clinics, 1 in the emergency department, 3 in ancillary care areas, and 3 on hospital medical/surgical wards that did not provide care for patients with known COVID-19 infection. Eighty-one of 82 (99%) symptomatic COVID-19 cases and 31 of 35 (89%) asymptomatic cases occurred in health care personnel. Sequencing analysis provided support for several transmission events between coworkers and in 2 cases supported transmission from health care personnel to patients. There were no documented transmissions from patients to personnel.

Conclusions
Clusters of COVID-19 with nosocomial transmission predominantly involved health care personnel and often occurred in outpatient clinics and ancillary care areas. There is a need for improved measures to prevent transmission of SARS-CoV-2 by health care personnel in inpatient and outpatient settings.
Speaking in Hands: Early Modern Preaching and Signed Languages for the Deaf
Authors: Oates Rosamund 
Published: June 2021

Abstract
This article demonstrates that deaf men and women were integrated into early modern communities through use of sign language, and that Protestant concerns about preaching and hearing promoted sign language as a legitimate form of communication. Historians have believed that the Protestant emphasis on preaching excluded deaf people from heaven. However, not only did contemporaries believe that deaf people could be saved, but debates on this topic prompted a wider assessment of the nature of hearing loss and sensory knowledge. Discussions about deafness therefore had implications for all congregations, as English preachers used well-known manual gestures from rhetorical texts to make their sermons accessible for both the ‘spiritually’ and the ‘physically’ deaf. The experiences of deaf people in early modern England demonstrate the importance of religious practices in shaping perceptions of disability and impairment. By focusing on deaf parishioners, it is possible to explore some of the impacts of the Reformation on ideas of embodiment while modifying literary accounts of the representation of disability in the period. A little-known part of early modern history, the role of preachers in the evolution of signed languages for the deaf offers new perspectives on Reformation history and the growing field of disability history.
SlHair2 Regulates the Initiation and Elongation of Type I Trichomes on Tomato Leaves and Stems
Authors: Chun Jae-In , Kim Seong-Min , Kim Heejin , Cho Jae-Yong , Kwon Hyun-Woo , Kim Jeong-Il , Seo Jang-Kyun , Jung Choonkyun , Kang Jin-Ho 
Published: June 2021

Abstract
Trichomes are hair-like structures that are essential for abiotic and biotic stress responses. Tomato Hair (H), encoding a C2H2 zinc finger protein, was found to regulate the multicellular trichomes on stems. Here, we characterized Solyc10g078990 (hereafter Hair2, H2), its closest homolog, to examine whether it was involved in trichome development. The H2 gene was highly expressed in the leaves, and its protein contained a single C2H2 domain and was localized to the nucleus. The number and length of type I trichomes on the leaves and stems of knock-out h2 plants were reduced when compared to the wild-type, while overexpression increased their number and length. An auto-activation test with various truncated forms of H2 using yeast two-hybrid (Y2H) suggested that H2 acts as a transcriptional regulator or co-activator and that its N-terminal region is important for auto-activation. Y2H and pull-down analyses showed that H2 interacts with Woolly (Wo), which regulates the development of type I trichomes in tomato. Luciferase complementation imaging assays confirmed that they had direct interactions, implying that H2 and Wo function together to regulate the development of trichomes. These results suggest that H2 has a role in the initiation and elongation of type I trichomes in tomato.
Partners of female patients with rheumatoid arthritis and reproductive decision-making: a constructivist grounded theory study
Authors: Garg Ria , Rebić Nevena , Amiri Neda , Hazlewood Glen , Baldwin Corisande , Ensworth Stephanie , Proulx Laurie , De Vera Mary A 
Published: June 2021

Abstract

Objective
Partners of patients with RA often take on supportive roles given the debilitating nature of RA. Our objective was to explore the perspectives, attitudes and experiences of partners of female patients with RA regarding reproductive experiences and decision-making.

Methods
We conducted a qualitative study involving semi-structured interviews with partners of female patients with RA. We defined a partner as an individual within a romantic relationship. Constructivist grounded theory was applied to interview transcripts to identify and conceptualize themes.

Results
We interviewed 10 partners of female patients with RA (10 males; mean age, 35 [23–56] years), of whom 40% had at least one child with a female patient with RA and did not desire additional children. We identified four themes representing stages of reproductive decision-making: (1) developing an understanding of RA, (2) contemplating future family decision-making, (3) initiating reproductive decision-making with partner, and (4) reflecting on past reproductive experiences. Participants contemplated their attitudes and perspectives regarding pregnancy and used available information to support their partner’s medication decisions. When reflecting on their reproductive experiences, participants shared the impacts of past reproductive decisions on their romantic relationship and their mental health and wellbeing.

Conclusion
Our study highlights the need for comprehensive support for both female patients with RA and their partners at all stages of reproductive decision-making. Health-care providers can identify opportunities for intervention that involves female patients with RA and their partners to minimize stress and its negative impacts on the family.
Evolutionary history of Sundaland shrews (Eulipotyphla: Soricidae:Crocidura) with a focus on Borneo
Authors: Hinckley Arlo , Camacho-Sanchez Miguel , Ruedi Manuel , Hawkins Melissa T R , Mullon Madeleine , Cornellas Anna , Tuh Yit Yuh Fred , Leonard Jennifer A 
Published: June 2021

AbstractThe hyperdiverse shrew genus Crocidura is one of few small mammal genera distributed across Sundaland and all of its boundaries. This represents a rare opportunity to study the geological history of this region through the evolutionary history of these shrews. We generate a phylogeny of all recognized species of Sundaland Crocidura and show that most speciation events took place during the Pleistocene, prior to the inundation of the Sunda Shelf around 400 000 years ago. We find east–west differentiation within two separate lineages on Borneo, and that the current taxonomy of its two endemic species does not reflect evolutionary history, but ecophenotypic variation of plastic traits related to elevation. Sulawesi shrews are monophyletic, with a single notable exception: the black-footed shrew (C. nigripes). We show that the black-footed shrew diverged from its relatives on Borneo recently, suggesting a human-assisted breach of Wallace’s line. Overall, the number of Crocidura species, especially on Borneo, probably remains an underestimate.
Metabolism, the microbiome, and the circadian clock
Authors: Hooper Lora V. , Wang Yuhao , Kuang Zheng 
Published: June 2021

The intestinal microbiota has been identified as an environmental factor that markedly impacts energy storage and body fat accumulation, yet the underlying mechanisms remain unclear. We have shown that the microbiota regulates body composition through the circadian transcription factor NFIL3. Nfil3 transcription oscillates diurnally in intestinal epithelial cells and the amplitude of the circadian oscillation is controlled by the microbiota through group 3 innate lymphoid cells (ILC3), STAT3, and the epithelial cell circadian clock. NFIL3 controls expression of a circadian lipid metabolic program and regulates lipid absorption and export in intestinal epithelial cells. These findings provide mechanistic insight into how the intestinal microbiota regulates body composition and establish NFIL3 as an essential molecular link among the microbiota, the circadian clock, and host metabolism.Support or Funding InformationNIH grant R01 DK070855 (L.V.H.); Burroughs Wellcome Foundation Investigators in the Pathogenesis of Infectious Diseases Award (L.V.H.); the Welch Foundation (L.V.H.), and the Howard Hughes Medical Institute (L.V.H.)This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Interrogating endogenous neuromodulatory GPCR signal processing by real‐time imaging of cAMP dynamics through intact neuronal circuits
Authors: Muntean Brian S , Zucca Stefano , MacMullen Courtney M , Dao Maria T , Johnston Caitlin , Iwamoto Hideki , Blakely Randy D , Davis Ronald L , Martemyanov Kirill A 
Published: June 2021

The majority of neuromodulators exert their effects by activating G protein coupled receptors (GPCRs) which shape neuronal properties through the regulation of second messengers. The mechanisms of signal decoding at GPCRs amidst diversity of the effects associated with their ctivation remains elusive. Furthermore, there is a paucity of understanding of how GPCRs signal to produce unique responses impacting cellular physiology while converging on a limited set of second messenger signaling cascades. Although significant progress has been made studying GPCRs in reconstituted systems, information decoding processes by GPCRs in an endogenous setting is understood less due to a lack of appropriate tools. Here, we developed a novel in vivo reagent that allows monitoring GPCR signaling in the endogenous setting from genetically defined populations of cells. The approach takes advantage of knock‐in mice engineered to express a genetically encoded FRET‐based cAMP biosensor in a Cre‐dependent fashion. We applied this reagent to study integration of GPCR signals in striatal medium spiny neurons both in culture and in brain slices where intact circuits were activated by optogenetics. Combined with CRISPR/Cas9 genomic editing, this approach enabled us to identify individual receptors and analyze their contributions to downstream signaling in the native environment. We identified key spatial differences in pharmacological responsiveness by comparing dendritic regions with the neuronal cell body as well as plasma membrane and internal cellular signaling compartments. We then conducted comparative analysis of GPCR signaling mediated by two opposing circuits modulated by the neurotransmitter dopamine, revealing the mechanisms of dopaminergic processing as well as major differences in the generation of discrete second messenger signatures. We further demonstrate how cAMP signal processing mechanisms contribute to allostatic adaptations that imbalance tuning between striatal output neurons that may underlie states of reward and aversion.Support or Funding InformationNIH 1R01DK110621, APS STRIDE Undergraduate Summer Research Fellowship 1R25HL115473‐01.This work was supported by NIH grants: DA041207 (to B.S.M.), DA036596 (to K.A.M.), and DA026405 (to K.A.M.).