bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Influencing Nurses' Culturally Competent Cancer Care for LGBT Individuals in Taiwan: A Qualitative Study Applying the Socio‐Ecological Model
Authors: Wang Ya‐Ching , Miao Nae‐Fang , You Mei‐Hui , Wang Frank T. Y. , Hsu Chih‐Yun 
Published: February 2025

ABSTRACTAimsThis study explored the factors associated with oncology nurses' behaviour and intention to provide cancer care to lesbian, gay, bisexual, and transgender (LGBT) individuals in Taiwan.DesignA qualitative descriptive study.MethodsSemi‐structured interviews were conducted with 25 oncology nurses between August and October 2023. The interview data were analysed using the framework method (the socio‐ecological model) and constant comparative techniques.ResultsFactors associated with oncology nurses' behaviour and intentions to provide cancer care for LGBT individuals were categorised and presented by the levels of the social‐ecological model: (1) intrapersonal level: oncology nurses' attitudes toward LGBT populations and their experiences, confidence, and beliefs in providing cancer care for LGBT individuals; (2) interpersonal level: concerns or interactions with oncology nurses' colleagues, other heterosexual cancer patients, and managers; (3) community and organisation levels: organisational climate and related training courses; and (4) societal and policy level: policy regarding sexual orientation, gender identity collection, and social atmosphere.ConclusionMultilevel barriers associated with oncology nurses' behaviours and intentions to provide cancer care to LGBT individuals were identified. The study findings emphasised the importance of related training courses offered by organisations to reduce cancer care disparities among LGBT individuals. These courses also aim to enhance oncology nurses' confidence and comfort in delivering holistic and patient‐centred cancer care for this population.ImpactThe study findings can be employed to assist in developing related training courses and understand the challenges oncology nurses face when providing cancer care to LGBT individuals.Patient or Public ContributionNo patient or public contributions.
Comparison of Cardiovascular Outcomes Between Chlorthalidone and Hydrochlorothiazide in Hypertensive Patients
Authors: Lim Subin , Kim Ju Hyeon , Oh Seungmi , Hong Soon Jun , Yu Cheol Woong , Joo Hyung Joon , Kim Yong Hyun , Kim Eung Ju 
Published: February 2025

ABSTRACTChlorthalidone (CLTD) and hydrochlorothiazide (HCTZ) are widely used thiazide diuretics for hypertension management. This study aimed to evaluate and compare the cardiovascular outcomes of patients treated with CLTD versus HCTZ. This multicenter, retrospective cohort study utilized data from the Korea University Medical Center, derived from electronic health records. A total of 14 257 hypertensive patients treated with either CLTD (n = 1920) or HCTZ (n = 12 337) were identified. Patients were matched 1:1 using propensity scores, resulting in 1606 patients in each treatment group. Demographic and clinical characteristics, incidence of major adverse cardiovascular events (MACE), and safety profiles were analyzed. Baseline characteristics after propensity score matching were well balanced between the two groups. The average age was 61.8 ± 14.6 years for CLTD users, with 59.3% being male. The 3‐year MACE occurred in 1.2% of the CLTD group compared with 1.4% of the HCTZ group (hazard ratio 0.91, p = 0.77). For secondary outcomes, cardiovascular mortality was 0.2% in both groups (p = 0.92). Myocardial infarction occurred in 0.3% of CLTD users and 0.4% of HCTZ users (p = 0.65). The incidence of hypokalemia was 19.2% in the CLTD group versus 16.7% in the HCTZ group (p = 0.07). In conclusion, in hypertensive patients, CLTD and HCTZ showed comparable cardiovascular outcomes and safety profiles.
Cardiac Baroreflex Is Preserved After the Recovery From COVID‐19 Men and Women
Authors: Souza Roberto , Divino Beatriz , Rocha Helena N. M. , Lugon Jocemir R. , Rocha Natalia G. , Nobrega Antonio C. L. , Prodel Eliza 
Published: February 2025

ABSTRACTWe sought to investigate whether mild COVID‐19 impairs cardiac baroreflex sensitivity (cBRS), using the modified Oxford protocol, in young healthy men and women 12–14 weeks after recovering from the infection. Participants were distributed into two groups: Non‐COVID‐19 group (NCG: men n = 6 [30 ± 3years; 26 ± 1 kg/m2] and women n = 5 [25 ± 1 years; 25 ± 1 kg/m2]) and recovered from COVID‐19 group (RCG: men n = 6 [29 ± 3 years; 25 ± 1 kg/m2] and women n = 10 [32 ± 4 years; 22 ± 1 kg/m2]), the RCG tested positive (RT‐PCR) 12 to 14 weeks before the protocol. Beat‐to‐beat finger blood pressure (BP) and heart rate (HR) were measured during a bolus of sodium nitroprusside (SNP) and phenylephrine (PHE), in a control condition and during cold pressor test (CPT) and moderate dynamic handgrip exercise (GRIP). Resting systolic BP was higher in the RCG (135 ± 14 mmHg vs. 122 ± 12 mmHg, p = 0.01). Both CPT and GRIP maneuvers increased HR and BP; the bolus of SNP diminished BP and evoked a reflex‐mediated increase in HR; PHE increased BP, resulting in a reflex‐mediated decrease in HR. Of note, cBRS for decrease or increase of BP did not differ between groups under the studied conditions: control (SNP, p = 0.39; PHE, p = 0.50); CPT (SNP, p = 0.09; PHE: p = 0.82); and GRIP (SNP, p = 0.35; PHE, p = 0.53). In conclusion, mild COVID‐19 did not seem to impair cBRS in healthy young men and women 12–14 weeks after recovering from the infection.
Single‐cell genomics meets systems neuroscience: Insights from mapping the brain circuitry of stress
Authors: Hanchate Naresh K. 
Published: February 2025

AbstractResponses to external and internal dangers is essential for survival and homeostatic regulation. Hypothalamic corticotropin‐releasing hormone neurons (CRHNs) play a pivotal role in regulating neuroendocrine responses to fear and stress. In recent years, the application of neurogenetic tools, such as fiber photometry, chemogenetics and optogenetics, have provided new insights into the dynamic neuronal responses of CRHNs during stressful events, offering new perspectives into their functional significance in mediating neurobehavioural responses to stress. Transsynaptic viral tracers have facilitated the comprehensive mapping of neuronal inputs to CRHNs. Furthermore, the development and application of innovative single‐cell genomic tools combined with viral tracing have begun to pave the way for a deeper understanding of the transcriptional profiles of neural circuit components, enabling molecular‐anatomical circuit mapping. Here, I will discuss how these systems neuroscience approaches and novel single‐cell genomic methods are advancing the molecular and functional mapping of stress neurocircuits, their associated challenges and future directions.
Amyloid‐β and Bacterial Lipopolysaccharide at Implants With Peri‐Implantitis: Ex Vivo Colocalization and Decontamination Protocol
Authors: Toledano‐Osorio Manuel , Cifuentes‐Jiménez Carolina , Toledano Manuel , Sanz Mariano , Raquel Osorio 
Published: February 2025

ABSTRACTAimTo study the differential presence of amyloid‐β and bacterial lipopolysaccharide (LPS) in freshly extracted titanium implants, either affected by peri‐implantitis (PI) or explanted by other causes, and to address a method for removal LPS and amyloid‐β from contaminated surfaces.MethodsTwenty‐four explanted implants were harvested from patients with (n = 12) or without (n = 12) peri‐implantitis, and their surfaces were analyzed by attenuated total reflectance (ATR) and Fourier transform infrared spectroscopy (FTIR) to localize amyloid‐β and LPS. Presence of amyloid‐β on the implants surfaces was further analyzed by light microscopy after specific amyloid staining with Congo red. Titanium discs were contaminated with LPS and amyloid‐β, these discs as well as six contaminated implants were treated with 0.25% NaOCl to assess its decontamination ability.ResultsLPS and amyloid‐β were observed at PI affected implant surfaces, but not in implants extracted by other causes. 0.25% NaOCl application was an efficient method for removing LPS and amyloid‐β from titanium surfaces.ConclusionsThe concurrent presence of LPS and amyloid‐β on the surface of implants affected by PI was demonstrated and it may act as potential comediators of PI inflammatory process. Eliminating these products from implants surfaces is possible after a proteolytic agent (0.25% NaOCl) application.
Aberrant Resting‐State Effective Connectivity Between the Insula and Other Regions of the Whole Brain in Children With Obstructive Sleep Apnea
Authors: Ji Tingting , Li Xiaodan , Xu Zhifei , Zhao Jing , Wang Guixiang , Li Yanzhen , Zhang Xuexi , Liu Qiaoyin , Sun Nian , Mei Lin , Wang Shengcai , Ni Xin 
Published: February 2025

ABSTRACTTo investigate the effective connectivity between the bilateral insulae and other regions of the whole brain in children with obstructive sleep apnea (OSA), and to reveal the relationships between these abnormal connections and cognitive dysfunction in this condition. Resting‐state functional magnetic resonance imaging (rs‐fMRI) data and clinical variables were collected from 55 children with OSA [5.0 (5.0, 8.0) years, 32 males, 28 pre‐school children] and 25 healthy controls [6.0 (5.0, 9.0) years, 11 males, 9 pre‐school children], matched for age, gender, and education. Rs‐fMRI data were analysed to investigative group‐difference in the effective connectivity between the bilateral insulae and other regions of the brain of children with OSA with those of controls. Spearman correlation analysis was conducted between these abnormal connections and clinical variables among children with OSA. Compared with controls, children with OSA showed abnormal clinical variables (i.e., increased OAHI, AHI, OAI, HI, ODI, time of SpO2 < 90%, total AI, and respiratory‐related AI, while decreased minimal SpO2, FIQ, VIQ, and PIQ). Additionally, significant alterations were observed in the effective connectivity between the bilateral insulae and other regions of brain, such as frontal, parietal, occipital, and cerebellum and so forth. Furthermore, the mean values of the effective connectivity in children with OSA were significantly correlated with several sleep‐related and neurocognitive parameters. There exist abnormal causal interactions between the bilateral insulae and other regions throughout the brain in OSA children, accompanied by impaired cognitive function, suggesting that the former may be a potential neural mechanism underlying the latter.
Mixed Parentage Broods Indicate Group Spawning in the Brood Parasitic Cuckoo Catfish
Authors: Zimmermann Holger , Sefc Kristina M. , Blažek Radim , Bartáková Veronika , Bryjová Anna , Katongo Cyprian , Koblmüller Stephan , Reichard Martin 
Published: February 2025

ABSTRACTObligate brood parasites delegate the workload of costly parental care to their hosts. Theory predicts that release from demanding parental care increases the importance of other factors to shape mating patterns. However, behavioural observations and parentage estimates are notoriously difficult to obtain in species with covert reproductive strategies, such as brood parasites, and evidence for their mating strategies are scarce. Molecular genetic methods provide a powerful tool to identify concealed mating patterns. Here, we reconstruct the parentage of cuckoo catfish (Synodontis multipunctatus) clutches collected in the wild using a combination of newly developed microsatellite markers, mitochondrial markers, and maximum likelihood estimates of pairwise relatedness. Cuckoo catfish parasitise mouthbrooding cichlids in Lake Tanganyika, but a natural spawning of the brood parasite has never been observed. We examined 429 females of confirmed host cichlid species (parasitism prevalence 6%; 24 parasitised clutches with 1–14 embryos) and found that 46% of clutches with three or more offspring (i.e., 6 out of 13) were parented by more than two catfish individuals. We demonstrated variable mating patterns including polyandrous and polygynous mating, and host sharing by separate, genetically monogamous, catfish pairs. This indicates that cuckoo catfish parasitism involves groups of catfish with reduced capability to monopolise mating opportunities. In general, our results demonstrate how reproductive strategy and mating patterns in a species with concealed breeding behaviour can be investigated and provide valuable insights into the mating system of a brood parasitic species other than hitherto studied avian brood parasites.
Decolonization
Authors: McMullin Juliet 
Published: February 2025

AbstractMuch has been written about decolonizing practices in the academy. This essay engages the conversation by focusing on the analysis phase of research to consider how research continues to be a process of colonization and epistemicide. Advances in community‐engaged research (CEnR) ameliorate some issues of inclusion. Yet, institutional procedures and claims to methods that entrench a scientifically enlightened way of knowing continue to systematically exclude Indigenous knowledge and many other systems of knowledge. Indeed, Tuck and Yang's question about what is distinct and sovereign, remains. Drawing on the analysis phase of a CEnR project with Native Americans, we describe our process for centering Indigenous epistemologies. While data gathering and analysis were inclusive, we were not always successful in maintaining the community partner's sovereignty. This example demonstrates the challenges of institutions that long for us to forget that there are other ways of knowing, and the promises of relational thinking and being as anti‐oppressive, though not yet decolonized research. Pausing to examine our practices during the analysis phase of research allows us to ask and enact different forms of relationality and reimagine how we come to know.
The Role of Illness Perception and Help‐Seeking Attitudes on Positive Psychological Well‐Being and Quality of Life in People With Chronic Wounds
Authors: Liu Yingchun , Wu Bin , Yu Jiping , Su Rong , Hong Yaping , Shi Qiong , Chen Ping , Zhang Jianfang 
Published: February 2025

ABSTRACTChronic wounds are a substantial health burden, adversely affecting patients' overall quality of life. This study explored the association between positive psychological well‐being and quality of life and the mediating roles of illness perceptions and attitudes toward medical help‐seeking among people with chronic wounds. A total of 208 people with chronic wounds from three hospitals in China were recruited. Data were collected using the Brief Illness Perception Questionnaire, Attitudes Toward Medical Help‐Seeking Scale, the Well‐being in Wounds Inventory, and the Questionnaire on Quality of Life with Chronic Wounds. Participants reported poor health‐related quality of life. The structural equation model revealed that the overall indirect impact of positive psychology on quality of life was 38.93%. This impact was divided into three components: disease perception accounted for 26.67% of the total indirect effect, attitude toward medical care accounted for 8.50%, and the combined effect of both factors accounted for 3.75%. This suggests that higher positive psychological well‐being may lead to higher quality of life by reducing illness perception and improving attitudes toward medical help‐seeking.
Plants as biofactories for production of the aphid sex pheromone nepetalactone
Authors: Ontiveros‐Cisneros Abraham , Salfeld Jule , Ding Bao‐Jian , Wang Hong‐Lei , Moss Oliver , Friberg Magne , Van Moerkercke Alex , Löfstedt Christer , Van Aken Olivier 
Published: February 2025

AbstractAphids cause massive agricultural losses through direct damage or as pathogen vectors. Control often relies on insecticides, which are expensive and not selective. An interesting alternative is to use aphid sex pheromones nepetalactone (NON) and nepetalactol (NOL) to interfere with aphid mating or attract aphid predators. Here, we explore production of these compounds in plants, as their precursors can be derived from mevalonate (MVA) and methylerythritol phosphate (MEP) pathways. By introducing six genes, including a major latex protein‐like (MLPL) enzyme, we engineered a functional nepetalactol biosynthetic pathway into plants. Transient expression of these enzymes in N. benthamiana caused production of nepetalactone, without the need for external supplementation with substrates. Targeting all six enzymes into the chloroplast appeared to result in higher NON yields than just chloroplast‐targeting the first two enzymes. We could not detect NOL, suggesting it is rapidly oxidised to NON. In addition, we produced NON in stably transformed Camelina sativa (Camelina) lines. Interestingly, the specific NON enantiomer was different in N. benthamiana compared to in Camelina, indicating the value of different platforms for producing specific isoforms. This opens possibilities for using plants as green factories of pheromones for baits or as pheromone dispensers that interfere with insect behaviour.
The Cyclin‐Dependent Kinase activity modulates the central carbon metabolism in maize during germination
Authors: Lara‐Núñez Aurora , Garza‐Aguilar Sara Margarita , Páez‐Franco José Carlos , de Dios Galindo‐de‐la‐Rosa Juan , Vallejo‐Becerra Vanessa 
Published: February 2025

AbstractThe cell cycle is predominantly controlled by Cyclins/Cyclin‐Dependent Kinases (Cyc/CDK) complexes, which phosphorylate targets involved in cellular proliferation. Evidence suggests that Cyc/CDK targets extend beyond traditional proteins and include enzymes that regulate the central carbon metabolism. Maize embryo axes rapidly internalize and metabolize glucose. After 24 h of imbibition in glucose‐rich media, axes exhibited increased length and weight, with more pronounced effects at 72 h. This morphology enhancement was impaired when RO‐3306, a specific CDK inhibitor, was added. The protein profile of maize embryo extracts at 18 and 24 h indicated altered phosphorylation patterns following CDK activity inhibition. Metabolomic analysis at 24 h of imbibition revealed that maize embryos without sugar in the media, with or without RO‐3306, had a decreased sugar and amino acid content. Conversely, axes exposed to glucose demonstrated increased conversion into various mono and di‐saccharides such as fructose, mannitol, galactose, and maltose but not sucrose. This pattern was reversed upon the addition of RO‐3306. Glucose promoted the accumulation of amino acids such as cysteine, valine, leucine, and intermediates of the tricarboxylic acid (TCA) cycle, such as malate and citrate. The CDK inhibitor redirected the glucose metabolism toward increased serine levels, followed by other amino acids like phenylalanine, valine, and leucine. Additionally, TCA cycle intermediates and sterols significantly decreased. Overall, these results contribute to understanding the role of CDK in maize morphogenesis during germination and underscore its impact on modulating various central carbon pathways, including glycolysis, amino acid catabolism/anabolism, TCA cycle, and sterols biosynthesis.
The role of institutional factors in shaping university mission statements: A topic‐modeling approach
Authors: Philippczyck Nicole , Hoffmann Harry , Oertel Simon 
Published: February 2025

AbstractMission statements are common instruments for the strategic positioning of universities. However, there are few large‐scale, cross‐national studies examining the factors that influence the content of universities' mission statements. We address this research gap, exploring the content of 413 mission statements from European universities by applying correlated topic modeling (CTM). Moreover, relying on institutional theories of organization, we study factors that explain differences in the content of mission statements. Our findings reveal six distinct topics addressed in mission statements. The prevalence of a specific topic is significantly shaped by the cultural rationalization of the universities' national context, the university's founding context, and institutional control. Our findings not only contribute to research on universities' strategic positioning but also shed light on the diffusion of global trends across organizations and the determinants of their adaptation. Moreover, our study offers an illustrative example of how big data analytics can enhance public administration research.
Development and Validation of a Risk Prediction Model to Identify Women With Chronic Obstructive Pulmonary Disease for Proactive Palliative Care
Authors: Gebresillassie Begashaw Melaku , Attia John , Cavenagh Dominic , Harris Melissa L. 
Published: February 2025

ABSTRACTBackground and ObjectiveProactive palliative interventions can improve symptom control and quality of life in individuals with chronic obstructive pulmonary disease (COPD); however, they are often underutilised. This study aimed to develop and validate a prediction model to identify women with COPD in their last year of life to facilitate timely palliative care referrals and interventions.MethodsData from 1236 women diagnosed with COPD from the 1921–1926 Australian Longitudinal Study on Women's Health cohort, linked to administrative health records, were analysed. We employed Lasso regression and multivariable logistic regression to select predictors. To assess the predictive performance of the model, we used the area under the receiver operating characteristic (AUROC) curve, calibration plot, and calibration metrics. The Youden index was used to establish the optimal cutoff point for risk classification. The clinical utility of the model was evaluated using decision curve analysis (DCA).ResultsThe final model to predict 1‐year all‐cause mortality included six predictors: smoking status, body mass index, needing regular assistance with daily activities, number of supplied medications, duration of illness, and number of hospital admissions. The model performed well, with AUROC of 0.82 (95% CI: 0.80–0.85) and showed excellent calibration. Using a cutoff of 56.6% predicted risk, the model achieved a sensitivity of 72.3%, specificity of 77.7%, and accuracy of 75.0%. The DCA indicated that the model provided a greater net benefit for clinical decision‐making.ConclusionOur prediction model for identifying women with COPD who may benefit from palliative care has shown robust predictive performance and can be easily applied, but requires external validation.
Goldenhar Syndrome and Its Clinical Manifestation With Dentofacial Considerations: A Case Report
Authors: Somkuwar Jay Kishor , Parasramka Pallavi , Ansari Afroz Alam , Singh Rajeev Kumar 
Published: February 2025

ABSTRACTGoldenhar syndrome, a variant of hemifacial microsomia, is a rare congenital condition characterized by mandibular hypoplasia, epibulbar dermoids, preauricular tags, and vertebral anomalies. This article discusses the case of a young boy presenting with classical signs of Goldenhar syndrome along with bilateral mandibular second premolar (BMSP) agenesis. While this syndrome can lead to significant physical and functional difficulties, timely recognition and tailored management are pivotal in enhancing the patient's quality of life and long‐term health outcomes.
Toward delirium: Comments on Russell Ford's Experience and Empiricism
Authors: Bell Jeffrey A. 
Published: February 2025

AbstractThis is an invited book symposium submission (invited by Mary Beth Mader). In these comments I summarize the strengths of Ford's recent book on Deleuze's work on Hume. I argue that while Ford has contributed an important book to both the scholarship on Deleuze's early work and on the intellectual history of mid‐twentieth century French philosophy, there are a few issues I seek to flesh out in these comments that are nonetheless in the spirit of Ford's overall project. In particular, I show how Deleuze offers a unique reading of Hume that ought to be taken more seriously by Hume scholars—a point Ford does not stress—and I argue that in addition to the influence of Jean Wahl, which Ford details superbly, the work of Sartre is also critical to understanding Deleuze's early philosophical writings.