bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomarkers and cell-based models to predict the outcome of neoadjuvant therapy for rectal cancer patients
Authors: Alkan Aylin , Hofving Tobias , Angenete Eva , Yrlid Ulf 
Published: July 2021

AbstractRectal cancer constitutes approximately one-third of all colorectal cancers and contributes to considerable mortality globally. In contrast to colon cancer, the standard treatment for localized rectal cancer often involves neoadjuvant chemoradiotherapy. Tumour response rates to treatment show substantial inter-patient heterogeneity, indicating a need for treatment stratification. Consequently researchers have attempted to establish new means for predicting tumour response in order to assist in treatment decisions. In this review we have summarized published findings regarding potential biomarkers to predict neoadjuvant treatment response for rectal cancer tumours. In addition, we describe cell-based models that can be utilized both for treatment prediction and for studying the complex mechanisms involved.
Targeting neoantigens for cancer immunotherapy
Authors: Zhao Xuan , Pan Xiaoxin , Wang Yi , Zhang Yi 
Published: July 2021

AbstractNeoantigens, a type of tumor-specific antigens derived from non-synonymous mutations, have recently been characterized as attractive targets for cancer immunotherapy. Owing to the development of next-generation sequencing and utilization of machine-learning algorithms, it has become feasible to computationally predict neoantigens by depicting genetic alterations, aberrant post-transcriptional mRNA processing and abnormal mRNA translation events within tumor tissues. Consequently, neoantigen-based therapies such as cancer vaccines have been widely tested in clinical trials and have demonstrated promising safety and efficacy, opening a new era for cancer immunotherapy. We systematically summarize recent advances in the identification of both personalized and public neoantigens, neoantigen formulations and neoantigen-based clinical trials in this review. Moreover, we discuss future techniques and strategies for neoantigen-based cancer treatment either as a monotherapy or as a combination therapy with radiotherapy, chemotherapy or immune checkpoint inhibitors.
EUV signals associated with O+ ions observed from ISS-IMAP/EUVI in the nightside ionosphere
Authors: Nakano Shin’ya , Hozumi Yuta , Saito Akinori , Yoshikawa Ichiro , Yamazaki Atsushi , Yoshioka Kazuo , Murakami Go 
Published: July 2021

AbstractThe extreme ultraviolet (EUV) imager, EUVI-B, on board the International Space Station (ISS) under the International Space Station–ionosphere-mesosphere-atmosphere plasmasphere cameras (ISS-IMAP) mission was originally intended to observe EUV emissions at 83.4 nm scattered by $${\mathrm O}^+$$

O

+

ions. During the mission, EUVI-B occasionally detected evident EUV signals in the umbra of the Earth. However, the source of the signals has not been verified. To evaluate the effect of the 83.4 nm EUV, we conduct a Monte Carlo simulation which considers multiple scattering of the 83.4 nm EUV by $${\mathrm O}^+$$

O

+

ions. In addition, we modeled the contribution of the 91.1 nm emission, which is due to recombination of $${\mathrm O}^{+}$$

O

+

ions and electrons, because the 91.1 nm EUV might affect the measurement from EUVI-B due to the wavelength range covered. The results suggest that the effect of the 83.4 nm EUV is likely to be negligible while the 91.1 nm EUV explains the observations from EUVI-B morphologically and quantitatively. We therefore conclude that the EUV signals observed by EUVI-B in the umbra of the Earth can largely be attributed to 91.1 nm emission due to recombination. This conclusion would facilitate the use of the EUVI-B data for reconstructing the $${\mathrm O}^+$$

O

+

density.
Mining methods and typical structural mechanisms of terpene cyclases
Authors: Huang Zheng-Yu , Ye Ru-Yi , Yu Hui-Lei , Li Ai-Tao , Xu Jian-He 
Published: July 2021

AbstractTerpenoids, formed by cyclization and/or permutation of isoprenes, are the most diverse and abundant class of natural products with a broad range of significant functions. One family of the critical enzymes involved in terpenoid biosynthesis is terpene cyclases (TCs), also known as terpene synthases (TSs), which are responsible for forming the ring structure as a backbone of functionally diverse terpenoids. With the recent advances in biotechnology, the researches on terpene cyclases have gradually shifted from the genomic mining of novel enzyme resources to the analysis of their structures and mechanisms. In this review, we summarize both the new methods for genomic mining and the structural mechanisms of some typical terpene cyclases, which are helpful for the discovery, engineering and application of more and new TCs.
Spatiotemporal patterns of sediment deposition on the northern slope of the South China Sea in the last 150,000 years
Authors: Hu Zhe , Huang Bao-Qi , Liu Le-Jun , Wang Na 
Published: July 2021

AbstractThe source-to-sink system of the northern South China Sea (SCS) has been widely discussed during the past few decades. Sr–Nd isotope, clay minerals and trace elements were extensively used as the proxies of sediment provenance, however, still little is known about the transport processes and controlling mechanisms on detailed spatiotemporal scales due to the limitations of these methods. Here we put forward the new provenance proxies RAK and RKCN based on major element compositions to study the spatiotemporal changes in sediment provenance since 150 ka mainly from four sites, DLW3101, MD12-3429, ZHS-176 and MD12-3432, which are located on the northern SCS continental slope. Our results show that, spatially, the pathways and intensities of contour currents and gravity flows play important roles in sediment transport. For alongslope processes, the South China Sea Branch of Kuroshio Current (SCSBKC) and the Deep Water Current (DWC) transport sediments from southwestern Taiwan, while the Intermediate Water Current (IWC) can carry sediments from Hainan, the Red River or the Indochina Peninsula. For downslope processes, gravity flows transport materials from the Pearl River delta and shelf to the slope. Moreover, seafloor bathymetry influences sediment transport by altering the pathways of ocean currents. Temporally, the impacts of sea level and monsoon rainfall fluctuations are always superimposed over the last 150 ka. Sea level fluctuations could significantly change the distance from the Pearl River estuary to the slope, while variations in the East Asian summer monsoon (EASM) rainfall would affect continental erosion rates in the source regions.
Rendang lokan: history, symbol of cultural identity, and food adaptation of Minangkabau tribe in West Sumatra, Indonesia
Authors: Fatimah Siti , Syafrini Delmira , Wasino  , Zainul Rahadian 
Published: July 2021

AbstractRendangis a kind of food that has become one of cultural heritages of Minangkabau tribe. It is not only a local food that has been crowned the best food in the world by CNN, but it also serves as the cultural identity. Most of people think that rendang is only made from beef of buffalo meat. In fact, rendang has many varieties that relate to the types of the area and the local natural resources where it is cooked. West Sumatra consists of mountainous and coastal areas. One of the popular rendang varieties in coastal areas isRendang Lokan—it is not made from beef but oyster (lokan). Rendang Lokan is a kind of food for people who live in this area. They use resources of the sea for their foods. Rendang, for Minangkabau tribe, is not only considered as a traditional food but also as a symbol of cultural identity from a certain area. This article is aimed at discussing the history of using Oyster as the main ingredient for rendang as one of the rendang varieties coming from the coastal areas in West Sumatra. The results show that rendang lokan is a representation of the characteristics of Minangkabau people who have the ability to adapt themselves to the local environmental conditions in maintaining their cultural identity. Rendang lokan was initially created as the adjustment of the Minangkabau people who live in the coastal areas to the local natural resources and their economic conditions.
Ethnomedical uses, chemical constituents, and evidence-based pharmacological properties of Chenopodium ambrosioides L.: extensive overview
Authors: Kasali Félicien Mushagalusa , Tusiimire Jonans , Kadima Justin Ntokamunda , Agaba Amon Ganafa 
Published: July 2021

Abstract
Background
The Chenopodium genus is a plant family widely spread worldwide that includes various plant species reputed to possess several medicinal virtues in folk medicines. Chenopodium ambrosioides L. is among the most used plants in traditional medicines worldwide. This review aimed to highlight ethnomedicinal uses, phytochemical status, and pharmacological properties of C. ambrosioides L.

Main body of the abstract
The analysis of relevant data highlights various ethnomedicinal uses against human and veterinary diseases in forty countries. Most indications consisted of gastrointestinal tract dysfunctioning troubles and worms parasitemia. Around 330 chemical compounds have been identified in different plant parts, especially in its essential oil fractions (59.84%). However, only a few compounds—mainly monoterpenes and glycosides—have been isolated and characterized. Experimental pharmacological studies validated a large scale of significant health benefits. It appeared that many monoterpenes are antioxidant, insecticidal, trypanocidal, analgesic, antifungal, anti-inflammatory, anti-arthritic, acaricidal, amoebicidal, anthelmintic, anticancer, antibacterial, antidiabetic, antidiarrheal, antifertility, antifungal, anti-leishmanial, antimalarial, antipyretic, antisickling, antischistosomal, antiulcer, anxiolytic, immunomodulatory, molluscicidal, and vasorelaxant agents.

Short conclusion
Thus, the Chenopodium ambrosioides species necessitates further chemical studies to isolate and characterize new bioactive secondary metabolites and pharmacological investigations to precise the mechanisms of action before clinical trials.
Arabic translation and validation of the Sinus and Nasal Quality of Life Survey (SN-5) in pediatric patients with chronic rhinosinusitis
Authors: Ragab Ahmed A. , Kasemy Zeinab A. , Hamdan Ahmad M. 
Published: July 2021

Abstract
Background
This study aimed to validate the translation of the Sinus and Nasal Quality of Life Survey (SN-5) into Arabic (SN-5a) in pediatric chronic rhinosinusitis (CRS) patients. A prospective cohort randomized controlled study was conducted on 129 children with CRS and 100 age- and sex-matched healthy children. The questionnaire was translated into the Arabic language with cross-cultural adaptation. Caregivers answered the questionnaire during their first visits and after 1 week; to assess test–retest reliability and after 2 weeks of medical treatment to test the questionnaire’s ability to detect changes in patients’ symptoms. The responses of the patients and control groups were compared to assess the external validity.

Results
The SN-5a showed internal consistency and reliability, with Cronbach’s alpha value being 0.69. Item–item and item–total correlation analysis showed adequate construct validity with a highly significant negative correlation between the SN-5 questionnaire items and visual analog scale (VAS) (p < 0.001). There were highly significant positive correlations between items of the questionnaire in the 1st and 2nd visits at 1 week (p < 0.001). A highly significant difference between the case and control groups had been shown for all SN-5a items (p < 0.001). Two weeks after treatment, there were large changes in all the questionnaire items between the first and last visits (effect size > 0.8 for all).

Conclusion
The translated SN-5a exhibited adequate construct validity, internal consistency, test–retest reliability, and external validity with quite enough ability to assess the longitudinal changes of the disease.
Language proficiency and mental disorders among migrants: A systematic review
Authors: Montemitro C. , D’Andrea G. , Cesa F. , Martinotti G. , Pettorruso M. , Di Giannantonio M. , Muratori R. , Tarricone I. 
Published: July 2021

AbstractBackgroundIn this review, we aimed to evaluate the association between language proficiency (LP) and the prevalence and severity of mental disorders in migrants. Secondarily, we aimed to consider whether sociodemographic and migration-related factors may affect the correlation between LP and mental disorders.MethodsMEDLINE, PsycArticles, EMBASE, and PsycInfo were systematically searched in April 2020 to identify original studies reporting prevalence of psychiatric symptoms or disorders among migrants and taking into account linguistic factors.ResultsThe search of electronic databases initially yielded 1,944 citations. Of the 197 full texts assessed for eligibility, 41 studies were selected for inclusion in the systematic review. Thirty-five of the papers included reported a significant negative association between low LP and prevalence and/or severity of psychiatric symptoms or disorders, whereas only two records found the opposite relationship and four papers reported no association between them. Inadequate LP was consistently associated with several mental disorders in migrants, including psychotic, mood, anxiety, and post-traumatic stress disorders. Notably, all the four longitudinal studies that met inclusion criteria for this review reported a positive effect of LP acquisition over time on prevalence or symptom severity of mental disorders.ConclusionsEven though larger prospective studies are needed to better evaluate the relationship between LP and psychiatric disorders among migrants, we believe that the present findings could be inspiring for authorities to provide support and courses to improve migrants’ language proficiency upon arrival.
Revised Neuroblastoma Risk Classification System: A Report From the Children's Oncology Group
Authors: Irwin Meredith S. , Naranjo Arlene , Zhang Fan F. , Cohn Susan L. , London Wendy B. , Gastier-Foster Julie M. , Ramirez Nilsa C. , Pfau Ruthann , Reshmi Shalini , Wagner Elizabeth , Nuchtern Jed , Asgharzadeh Shahab , Shimada Hiroyuki , Maris John M. , Bagatell Rochelle , Park Julie R. , Hogarty Michael D. 
Published: July 2021

PURPOSE Treatment planning for children with neuroblastoma requires accurate assessment of prognosis. The most recent Children's Oncology Group (COG) risk classification system used tumor stage as defined by the International Neuroblastoma Staging System. Here, we validate a revised classifier using the International Neuroblastoma Risk Group Staging System (INRGSS) and incorporate segmental chromosome aberrations (SCA) as an additional genomic biomarker. METHODS Newly diagnosed patients enrolled on the COG neuroblastoma biology study ANBL00B1 between 2007 and 2017 with known age, International Neuroblastoma Staging System, and INRGSS stage were identified (N = 4,832). Tumor MYCN status, ploidy, SCA status (1p and 11q), and International Neuroblastoma Pathology Classification histology were determined centrally. Survival analyses were performed for combinations of prognostic factors used in COG risk classification according to the prior version 1, and to validate a revised algorithm (version 2). RESULTS Most patients with locoregional tumors had excellent outcomes except for those with image-defined risk factors (INRGSS L2) with MYCN amplification (5-year event-free survival and overall survival: 76.3% ± 5.8% and 79.9% ± 5.5%, respectively) or patients age ≥ 18 months with L2 MYCN nonamplified tumors with unfavorable International Neuroblastoma Pathology Classification histology (72.7% ± 5.4% and 82.4% ± 4.6%), which includes the majority of L2 patients with SCA. For patients with stage M (metastatic) and MS (metastatic, special) disease, genomic biomarkers affected risk group assignment for those < 12 months ( MYCN) or 12-18 months ( MYCN, histology, ploidy, and SCA) of age. In a retrospective analysis of patient outcome, the 5-year event-free survival and overall survival using COG version 1 were low-risk: 89.4% ± 1.1% and 97.9% ± 0.5%; intermediate-risk: 86.1% ± 1.3% and 94.9% ± 0.8%; high-risk: 50.8% ± 1.4% and 61.9% ± 1.3%; and using COG version 2 were low-risk: 90.7% ± 1.1% and 97.9% ± 0.5%; intermediate-risk: 85.1% ± 1.4% and 95.8% ± 0.8%; high-risk: 51.2% ± 1.4% and 62.5% ± 1.3%, respectively. CONCLUSION A revised 2021 COG neuroblastoma risk classifier (version 2) that uses the INRGSS and incorporates SCAs has been adopted to prospectively define COG clinical trial eligibility and treatment assignment.
Can exposure to panoramic radiographs induce genotoxic effects on the oral epithelium? A systematic review with meta-analysis
Authors: Santos Marcos Antônio Lima dos , Couto Graziane Ribeiro , Sabey Mark Jon Santana , Borges Danilo de Paula Ribeiro , Takeshita Wilton Mitsunari 
Published: July 2021

Radiographic examinations combined with clinical and histological tests play an important role in diagnosing changes in the craniofacial region. Considering that X-radiation is a form of ionizing energy capable of damaging the DNA of individuals, it has been the object of studies since its introduction. The micronucleus test is used to quantify this damage, assessing whether or not chromosomal breakage occurs. Objective: To evaluate, through a systematic review (SR) with meta-analysis, the occurrence of genotoxic effects in the oral epithelium after the exposure of patients to panoramic radiographs. Methods: An SR was performed with the PICOS (Population, Intervention, Comparison, Outcome, and Study design) strategy, aiming to answer the following question: “Can panoramic radiographs induce genotoxic effects on the oral epithelium?” The study was registered in the PROSPERO (International prospective register of systematic reviews) platform. A systematic search was performed in the following electronic databases: PubMed (including MedLine), Scopus, Embase, LILACS, Medline EbscoHost, and Google Scholar. Treatment effects were defined as standardized mean difference (SMD), and 95% confidence intervals (CI) were established. The Joanna Briggs Institute questionnaire for observational studies was applied to assess the risk of bias. The GRADE tool was used to assess the quality of evidence of the SR. Results: A total of 251 potentially relevant studies were selected through the search strategy. After screening titles and abstracts, 11 full-text manuscripts were assessed for eligibility and nine observational studies were included in the meta-analysis. The present study showed an increase in micronuclei after the exposure (SMD = 0.21, 95% CI, 0.03 to 0.28, p = 0.02), with a Tau2index = 0.00, Chi2 = 2.35, and p-value = 0.97. Therefore, the articles selected were considered homogeneous and the I² of 0% indicated low heterogeneity. Conclusion: According to the studies analysed, although the quality of evidence was considered low, panoramic radiographs can cause genotoxic damage in the oral epithelium but with a small effect size.
Independent predictors of comprehensive knowledge of HIV in general population: findings from the Myanmar Demographic and Health Survey (2015-16)
Authors: Show Kyaw Lwin , Shewade Hemant Deepak , Kyaw Khine Wut Yee , Wai Khin Thet , Hone San , Oo Htun Nyunt 
Published: July 2021

Background: Myanmar has the third highest number of people living with HIV in Southeast Asia behind Indonesia and Thailand. The independent predictors of comprehensive HIV knowledge among general population are not known. Methods: In this nationally representative study, we adopted a cross-sectional design using secondary data from the Myanmar Demographic and Health Survey (2015-16). We included all women and men aged 15-49 years who participated in the survey. We have provided weighted estimates as the analyses were weighted for the multi-stage sampling design. We used modified Poisson regression with robust variance estimates model to identify independent predictors of comprehensive knowledge. Results: Of 17,622 analyzed, 3,599 (20.4%, 95% CI: 19.7, 21.1) had comprehensive knowledge of HIV. Late adolescents, those with less than a high school education, those involved in agriculture and the poorest two quintiles were less likely to have comprehensive knowledge of HIV. Conclusion: In Myanmar, comprehensive knowledge of HIV among the general population needs to be improved and we identified certain independent predictors that could be specifically targeted by the national programme.
Metronomic oral vinorelbine doublet chemotherapy with carboplatin in treatment of advanced lung cancer: a feasibility and safety study
Authors: Kandi Maria , Meldgaard Peter , Knap Marianne Marquard 
Published: July 2021

Background: Non-small cell lung cancer (NSCLC) is globally one of the most common forms of cancer. Palliative treatment is a delicate balance against toxicity and survival. Using small frequent doses of chemotherapy, metronomic regimens have been hypothesized to maintain or even improve efficacy while achieving a lower treatment-related toxicity. The mechanism is thought to result from a more continuous exposure of the tumour cells to the drugs. Treating NSCLC, this study addresses the feasibility and tolerability of carboplatin in combination with 12 weeks of daily metronomic vinorelbine. Method: Patients were included over a period of ten months. All patients had biopsy-verified incurable NSCLC and were candidates for first line chemotherapy (PD-L1<50% and no targetable mutations). This open label, non-randomized prospective safety and feasibility study was investigator initiated. Patients received up-to four cycles of standard dose carboplatin AUC 5 every third week in combination with 12 weeks of metronomic oral daily Navelbine® (20/30 mg). Patients were evaluated by CT scans after end of treatment and then every 8 weeks (+/- 1 week) until progression. Results: A total of 20 patients were included. Male/female-ratio was 4/16. Age ranged from 49-83 with a median of 70.5 years. Majority had adenocarcinoma (95%). Two patients withdrew their consent within a week. 18 patients were included in safety analysis. 13 received all four cycles. Grade 1/2 toxicity was frequently seen and included fatigue 13 (72%), diarrhoea 13 (72%), constipation/congestion 13 (72%). Grade 3 toxicities were dyspnoea 2 (11%), nausea 3 (17%) and fatigue 3 (17%). Two (11%) had grade 4 toxicity with neutropenic fever, both recovered. No grade 5 toxicity was detected. Conclusion: In treatment of NSCLC this study is the first addressing the regimen of carboplatin in combination with daily metronomic vinorelbine. We conclude that doublet chemotherapy with daily vinorelbine is safe and feasible.