bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overlap of autism spectrum disorder and borderline personality disorder: A systematic review and meta‐analysis
Authors: May Tamara , Pilkington Pamela D. , Younan Rita , Williams Katrina 
Published: October 2021

AbstractAutism spectrum disorder (ASD) and borderline personality Disorder (BPD) share features, including social and emotion regulation difficulties. The evidence for the overlap in prevalence and clinical characteristics was systematically reviewed. Ovid Medline, PsycInfo, and PubMed were searched until November 30, 2020 using keywords relating to BPD and ASD. Studies that reported on the overlap of ASD and BPD diagnoses or traits and used a case, cohort, or case‐controlled design were included. Of 1633 screened studies, 19 were included, of which 12 reported data suitable for meta‐analysis. Most samples were of small, clinically ascertained groups, with 11 having high risk of bias. The pooled prevalence of BPD in ASD was 4% [95% CI 0%–9%] and of ASD in BPD, 3% [95% CI 1%–8%]. There were inconsistent findings across clinical areas. The prevalence of a dual diagnosis of BPD in ASD cohorts and of ASD in BPD cohorts was within population prevalence estimates of each disorder. Based on this data we were not able to assess whether there is misdiagnosis of one in favor of the other. Neurocognitive differences may underlie similar behavioral symptoms, but further research using larger, well‐validated samples is needed.Lay SummaryAutism spectrum disorder (ASD) and borderline personality disorder (BPD) have overlaps in their symptoms. The overlap in how frequently they co‐occur and their presentation was systematically reviewed. We searched the key databases and including all studies that reported on the overlap of ASD and BPD diagnoses or traits and used a case, cohort or case‐controlled design. Of 1633 studies, 19 were included, of which 12 reported data suitable for pooling. Most samples were of small, clinical groups, with 11 having high risk of bias. The pooled prevalence of BPD in ASD was 4% [95% CI 0%–9%] and of ASD in BPD, 3% [95% CI 1%–8%]. There were inconsistent findings across studies comparing ASD and BPD related symptoms and problems. The prevalence of a dual diagnosis of BPD in ASD cohorts and of ASD in BPD cohorts was similar to the population prevalence of each disorder. Further research using larger, well‐validated samples is needed.
Designer nanoparticles for plant cell culture systems: Mechanisms of elicitation and harnessing of specialized metabolites
Authors: Arya Sagar S. , Lenka Sangram K. , Cahill David M. , Rookes James E. 
Published: October 2021

AbstractPlant cell culture systems have become an attractive and sustainable approach to produce high‐value and commercially significant metabolites under controlled conditions. Strategies involving elicitor supplementation into plant cell culture media are employed to mimic natural conditions for increasing the metabolite yield. Studies on nanoparticles (NPs) that have investigated elicitation of specialized metabolism have shown the potential of NPs to be a substitute for biotic elicitors such as phytohormones and microbial extracts. Customizable physicochemical characteristics allow the design of monodispersed‐, stimulus‐responsive‐, and hormone‐carrying‐NPs of precise geometries to enhance their elicitation capabilities based on target metabolite/plant cell culture type. We contextualize advances in NP‐mediated elicitation, especially stimulation of specialized metabolic pathways, the underlying mechanisms, impacts on gene regulation, and NP‐associated cytotoxicity. The novelty of the concept lies in unleashing the potential of designer NPs to enhance yield, harness metabolites, and transform nanoelicitation from exploratory investigations to a commercially viable strategy.
Trust and shared decision‐making among individuals with multiple myeloma: A qualitative study
Authors: Whitney Robin L. , White Anne Elizabeth Clark , Rosenberg Aaron S. , Kravitz Richard L. , Kim Katherine K. 
Published: October 2021

AbstractBackgroundMultiple myeloma (MM) is an incurable cancer with complex treatment options. Trusting patient–clinician relationships are essential to promote effective shared decision‐making that aligns best clinical practices with patient values and preferences. This study sought to shed light on the development of trust between MM patients and clinicians.MethodsNineteen individual semi‐structured interviews were conducted with MM patients within 2 years of initial diagnosis or relapse for this qualitative study. Interviews were recorded and transcripts were coded thematically.ResultsWe identified three main themes: (1) externally validated trust describes patients’ predisposition to trust or distrust clinicians based on factors outside of patient–clinician interactions; (2) internally validated trust describes how patients develop trust based on interactions with specific clinicians. Internally validated trust is driven primarily by clinician communication practices that demonstrate competence, responsiveness, listening, honesty, and empathy; and (3) trust in relation to shared decision‐making describes how patients relate the feeling of trust, or lack thereof, to the process of shared decision‐making.ConclusionMany factors contribute to the development of trust between MM patients and clinicians. While some are outside of clinicians’ control, others derive from clinician behaviors and interpersonal communication skills. These findings suggest the possibility that trust can be enhanced through communication training or shared decision‐making tools that emphasize relational communication. Given the important role trust plays in shared decision‐making, clinicians working with MM patients should prioritize establishing positive, trusting relationships.
Key stakeholder perspectives on primary care for young people with an eating disorder: A qualitative study
Authors: Malson Helen , Tischner Irmgard , Herzig Hugh , Kitney Danielle , Phillips Catherine , Norweg Sanni , Moon Jasmin , Holmes Su , Wild Katie , Oldham‐Cooper Rosie 
Published: October 2021

AbstractThis paper examines the provision of primary care for young people with an eating disorder within the UK from the perspectives of three key stakeholder groups: young people with an eating disorder, carers of young people with an eating disorder and General Practitioners (GPs). Twenty‐two young people with an eating disorder (aged 16–25) and 10 carers completed qualitative questionnaires or participated in interviews about their experiences of seeking primary care from GPs. Forty‐one GPs participated in either focus groups or interviews about delivering care to young people with eating disorders. Interviews and focus groups were audio‐recorded and transcribed verbatim. All data were then analysed qualitatively using thematic analysis. Our analysis indicates that GPs often felt they lacked the necessary knowledge and/or resources to provide adequate support to young people with an eating disorder who they also often viewed as a “difficult” patient group. Young people and carers expressed mixed but predominantly negative experiences; reporting that GPs often lacked adequate understanding of eating disorder, failed to take participants' concerns seriously, and delayed referring patients to specialist services. Our findings indicate a need for interventions that will improve primary care provision and access to appropriate support for young people with an eating disorder.
HaloTag Engineering for Enhanced Fluorogenicity and Kinetics with a Styrylpyridium Dye
Authors: Miró‐Vinyals Carla , Stein Alina , Fischer Sandro , Ward Thomas R. , Deliz Liang Alexandria 
Published: October 2021

AbstractHaloTag is a small self‐labeling protein that is frequently used for creating fluorescent reporters in living cells. The small‐molecule dyes used with HaloTag are almost exclusively based on rhodamine scaffolds, which are often expensive and challenging to synthesize. Herein, we report the engineering of HaloTag for use with a chemically accessible, inexpensive fluorophore based on the dimethylamino‐styrylpyridium dye. Through directed evolution, the maximum fluorogenicity and the apparent second‐order bioconjugation rate constants could be improved up to 4‐fold and 42‐fold, respectively. One of the top variants, HT‐SP5, enabled reliable imaging in mammalian cells, with a 113‐fold fluorescence enhancement over the parent protein. Additionally, crystallographic characterization of selected mutants suggests the chemical origin of the fluorescent enhancement. The improved dye system offers a valuable tool for imaging and illustrates the viability of engineering self‐labeling proteins for alternative fluorophores.
Management of upper retropharyngeal abscesses in children: Two case reports of a troublesome situation
Authors: Torretta Sara , Ibba Tullio , Guastella Claudio , Gaini Lorenzo , Di Cicco Maurizio , Folino Francesco , Marchisio Paola , Bosis Samantha , Pinzani Raffaella , D'Amico Mario , Pignataro Lorenzo 
Published: October 2021

AbstractManagement of upper retropharyngeal abscesses in children is challenging. In surgical cases, ultrasound‐assisted intra‐operative procedures may be helpful to reach peculiar locations, thus reducing surgical morbidity and complications rate.
Clinical Case Reports on the acceptability and tolerance of a High‐Energy whey peptide‐based Pediatric oral nutritional supplement in children aged over 12 months
Authors: Simpson Kathryn 
Published: October 2021

AbstractThe nutritional management of the complex needs of children with impaired gastrointestinal function can be challenging, using a high‐energy pediatric whey‐based peptide formula in clinical practice demonstrates its role in managing symptoms.
Complication following frenectomy: A case report
Authors: Sæthre Terje , Berg Einar , Bunæs Dagmar F. , Leknes Knut N. 
Published: October 2021

AbstractWhen performing a frenectomy in patients with an increased risk of exposing bone dehiscence, it is essential that the distance between the incisions is not too wide and that they are mainly made in the movable mucosa to secure optimal wound closure.
Synthesis and Physical Properties of Tunable Aryl Alkyl Ionic Liquids (TAAILs)
Authors: Lerch Swantje , Strassner Thomas 
Published: October 2021

AbstractTunable aryl alkyl ionic liquids (TAAILs) based on the imidazolium cation were first reported in 2009. Since then, a series of TAAILs with different properties due to the electron‐donating or ‐withdrawing effect of the substituents at the aryl ring has been developed. Herein, a wide variety of those ionic liquids (ILs) is presented in terms of their cation structure. The authors synthesized ILs containing the bromide or bis(trifluoromethane)sulfonimide anion and 1‐aryl‐3‐alkyl imidazolium cations with various substituents in the ortho and/ or para position of the phenyl ring and alkyl chains of different lengths varying from butyl to dodecyl. The differences of their physical properties (melting point, thermal decomposition, viscosity, electro‐chemical window) of these ILs are reported according to their structure.
New Cembrane‐Type Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata
Authors: Lin Na , Li Heng , Wang Jian‐Rong , Tang Wei , Zheng Ming‐Yue , Wang Hong , Jiang Cheng‐Shi , Guo Yue‐Wei 
Published: October 2021

Comprehensive SummaryIn the present study, nine new cembrane‐type diterpenoids, namely ximaonanolobatins A—I (1—9), together with six related known analogs (10—15) and four known tetraprenylated alkaloids malonganenones D, E, H, and K (16—19) were isolated from the soft coral Sinularia nanolobata collected off the Ximao Island in the South China Sea. The structures of 1—9 were robustly established by a combination of detailed spectroscopic analyses, chemical reactions, quantum mechanical (QM)‐NMR methods, biogenetic consideration, and the comparison with those literature data. The absolute configuration of 1 was confirmed by X‐ray diffraction analysis, and the absolute configuration of 2 was determined by QM‐NMR calculations and chemical transformation. In addition, the absolute configuration of 3 was determined using the modified Mosher's method. All these isolates were evaluated for their anti‐inflammatory and anti‐tumor activities. The results showed that only compound 15 exhibited potential anti‐inflammatory effect against LPS‐induced TNF‐α release in RAW264.7 macrophages with an IC50 value of 12.6 μmol/L.
Pharmacokinetics of Asciminib When Taken With Imatinib or With Food
Authors: Hoch Matthias , Zack Julia , Quinlan Michelle , Huth Felix , Forte Sofia , Dodd Stephanie , Aimone Paola , Hourcade‐Potelleret Florence 
Published: October 2021

AbstractAsciminib, a first‐in‐class, Specifically Targeting the Abelson kinase Myristoyl Pocket (STAMP) inhibitor with the potential to overcome resistance to adenosine triphosphate–competitive tyrosine kinase inhibitors, is being investigated in leukemia as monotherapy and in combination with tyrosine kinase inhibitors including imatinib. This phase 1 study in healthy volunteers assessed the pharmacokinetics of asciminib (40 mg single dose) under 2 conditions: when taken with imatinib (steady state; 400 mg once daily) and a low‐fat meal (according to imatinib prescription information), or when taken as single‐agent under different food conditions. Asciminib plus imatinib with a low‐fat meal increased asciminib area under the plasma concentration–time curve from time 0 to infinity and maximum plasma concentration (geometric mean ratios [90% confidence interval], 2.08 [1.93‐2.24] and 1.59 [1.45‐1.75], respectively) compared with asciminib alone under the same food conditions. Asciminib plus food decreased asciminib area under the plasma concentration–time curve from time 0 to infinity compared with asciminib taken under fasted conditions (geometric mean ratios: low‐fat meal, 0.7 [0.631‐0.776]; high‐fat meal, 0.377 [0.341‐0.417]). Asciminib plus imatinib was well tolerated with no new safety signals. Overall, coadministration of asciminib with imatinib and a low‐fat meal results in a moderate increase in asciminib exposure compared with asciminib alone under the same food condition. Food itself decreases asciminib exposure, indicating that single‐agent asciminib should be administered in the fasted state to prevent potential suboptimal exposures.
Oversampling the minority class using a dedicated fitness function and genetic algorithmic progression
Authors: Sadhukhan Payel , Palt Sarbani 
Published: October 2021

SummaryClass imbalance is a pertinent characteristic of a number of real‐world datasets. The underrepresentation of the minority class in such datasets causes difficulty in learning and prediction of its members. In this era of Big Data, we need to address this practical issue in order to get admissible outputs from our classifier models. We present a novel work, oversampling the minority class using a dedicated fitness function and genetic algorithmic progression – to tackle the problem of class imbalance. We generate a random set of feature points in the given space and use genetic‐algorithm guided progression to metamorphose them into a set of potential minority points. The optimization function looks at the neighborhood of the synthetic minority points for computing the fitness scores. We have employed 19 real‐world datasets, three metrics, three classifiers, and four diversified oversampling methods in the empirical study. A comprehensive study involving several well‐established minority oversamplers demonstrates the efficaciousness of the proposed method in handling class imbalance.
Parallel tensor decomposition with distributed memory based on hierarchical singular value decomposition
Authors: Fang Zisen , Qi Fumin , Dong Yichuan , Zhang Yong , Feng Shengzhong 
Published: October 2021

AbstractAs an important tool of multiway/tensor data analysis tool, Tucker decomposition has been applied widely in various fields. But traditional sequential Tucker algorithms have been outdated because tensor data is growing rapidly in term of size. To address this problem, in this article, we focus on parallel Tucker decomposition of dense tensors on distributed‐memory systems. The proposed method uses hierarchical SVD to accelerate the SVD step in traditional sequential algorithms, which usually takes up most computation time. The data distribution strategy is designed to follow the implementation of hierarchical SVD. We also find that compared with the state‐of‐the‐art method, the proposed method has lower communication cost in large‐scale parallel cases under the assumption of the α–β model.
Outcomes for infants whose mothers had an eating disorder in the perinatal period: A systematic review of the evidence
Authors: Mah Beth , Cibralic Sara , Hanna Joanne , Hart Melissa , Loughland Carmel , Cosh Suzanne 
Published: October 2021

AbstractObjectiveTo establish any health outcomes for infants to age one, associated with their mother having a diagnosis of an active eating disorder during pregnancy or the 12‐month postnatal period.MethodA qualitative systematic literature review of numerous databases (Medline, PsycINFO, CINAHL, Scopus, Cochrane Library, MedNar, PsycExtra, National Institute for Health and Care Excellence and Open Grey) was performed examining any infant health outcomes.ResultsThis resulted in 22 included studies (17 cohort, 3 cross‐sectional, 1 case controlled and 1 mixed methods study). A range of adverse infant outcomes including poor birth, growth and interactional feeding outcomes were identified.DiscussionAntenatal identification and treatment for women with an eating disorder during the perinatal period and their infants are vital. Optimizing pregnancy nutrition, maternal eating disorder symptoms and feeding interactions appear particularly important.
The iDiv Ecotron—A flexible research platform for multitrophic biodiversity research
Authors: Schmidt Anja , Hines Jes , Türke Manfred , Buscot François , Schädler Martin , Weigelt Alexandra , Gebler Alban , Klotz Stefan , Liu Tao , Reth Sascha , Trogisch Stefan , Roy Jacques , Wirth Christian , Eisenhauer Nico 
Published: October 2021

AbstractAcross the globe, ecological communities are confronted with multiple global environmental change drivers, and they are responding in complex ways ranging from behavioral, physiological, and morphological changes within populations to changes in community composition and food web structure with consequences for ecosystem functioning. A better understanding of global change‐induced alterations of multitrophic biodiversity and the ecosystem‐level responses in terrestrial ecosystems requires holistic and integrative experimental approaches to manipulate and study complex communities and processes above and below the ground. We argue that mesocosm experiments fill a critical gap in this context, especially when based on ecological theory and coupled with microcosm experiments, field experiments, and observational studies of macroecological patterns. We describe the design and specifications of a novel terrestrial mesocosm facility, the iDiv Ecotron. It was developed to allow the setup and maintenance of complex communities and the manipulation of several abiotic factors in a near‐natural way, while simultaneously measuring multiple ecosystem functions. To demonstrate the capabilities of the facility, we provide a case study. This study shows that changes in aboveground multitrophic interactions caused by decreased predator densities can have cascading effects on the composition of belowground communities. The iDiv Ecotrons technical features, which allow for the assembly of an endless spectrum of ecosystem components, create the opportunity for collaboration among researchers with an equally broad spectrum of expertise. In the last part, we outline some of such components that will be implemented in future ecological experiments to be realized in the iDiv Ecotron.
Identifying and correcting spatial bias in opportunistic citizen science data for wild ungulates in Norway
Authors: Cretois Benjamin , Simmonds Emily G. , Linnell John D. C. , van Moorter Bram , Rolandsen Christer M. , Solberg Erling J. , Strand Olav , Gundersen Vegard , Roer Ole , Rød Jan Ketil 
Published: October 2021

AbstractMany publications make use of opportunistic data, such as citizen science observation data, to infer large‐scale properties of species’ distributions. However, the few publications that use opportunistic citizen science data to study animal ecology at a habitat level do so without accounting for spatial biases in opportunistic records or using methods that are difficult to generalize. In this study, we explore the biases that exist in opportunistic observations and suggest an approach to correct for them. We first examined the extent of the biases in opportunistic citizen science observations of three wild ungulate species in Norway by comparing them to data from GPS telemetry. We then quantified the extent of the biases by specifying a model of the biases. From the bias model, we sampled available locations within the species’ home range. Along with opportunistic observations, we used the corrected availability locations to estimate a resource selection function (RSF). We tested this method with simulations and empirical datasets for the three species. We compared the results of our correction method to RSFs obtained using opportunistic observations without correction and to RSFs using GPS‐telemetry data. Finally, we compared habitat suitability maps obtained using each of these models. Opportunistic observations are more affected by human access and visibility than locations derived from GPS telemetry. This has consequences for drawing inferences about species’ ecology. Models naïvely using opportunistic observations in habitat‐use studies can result in spurious inferences. However, sampling availability locations based on the spatial biases in opportunistic data improves the estimation of the species’ RSFs and predicted habitat suitability maps in some cases. This study highlights the challenges and opportunities of using opportunistic observations in habitat‐use studies. While our method is not foolproof it is a first step toward unlocking the potential of opportunistic citizen science data for habitat‐use studies.