bluuebunny/crossref_metadata_2025_split huggingface dataset:
PACAP Induces Light Aversion in Mice by an Inheritable Mechanism Independent of CGRP
Authors: Kuburas Adisa , Mason Bianca N. , Hing Benjamin , Wattiez Anne-Sophie , Reis Alyssa S. , Sowers Levi P. , Moldovan Loomis Cristina , Garcia-Martinez Leon F. , Russo Andrew F. 
Published: April 2021

The neuropeptides CGRP (calcitonin gene-related peptide) and PACAP (pituitary adenylate cyclase-activating polypeptide) have emerged as mediators of migraine, yet the potential overlap of their mechanisms remains unknown. Infusion of PACAP, like CGRP, can cause migraine in people, and both peptides share similar vasodilatory and nociceptive functions. In this study, we have used light aversion in mice as a surrogate for migraine-like photophobia to compare CGRP and PACAP and ask whether CGRP or PACAP actions were dependent on each other. Similar to CGRP, PACAP induced light aversion in outbred CD-1 mice. The light aversion was accompanied by increased resting in the dark, but not anxiety in a light-independent open field assay. Unexpectedly, about one-third of the CD-1 mice did not respond to PACAP, which was not seen with CGRP. The responder and nonresponder phenotypes were stable, inheritable, and not sex linked, although there was a trend for greater responses among male mice. RNA-sequencing analysis of trigeminal ganglia yielded hierarchical clustering of responder and nonresponder mice and revealed a number of candidate genes, including greater expression of theTrpc5andKcnk12ion channels and glycoprotein hormones and receptors in a subset of male responder mice. Importantly, an anti-PACAP monoclonal antibody could block PACAP-induced light aversion but not CGRP-induced light aversion. Conversely, an anti-CGRP antibody could not block PACAP-induced light aversion. Thus, we propose that CGRP and PACAP act by independent convergent pathways that cause a migraine-like symptom in mice.SIGNIFICANCE STATEMENTThe relationship between the neuropeptides CGRP (calcitonin gene-related peptide) and PACAP (pituitary adenylate cyclase-activating polypeptide) in migraine is relevant given that both peptides can induce migraine in people, yet to date only drugs that target CGRP are available. Using an outbred strain of mice, we were able to show that most, but not all, mice respond to PACAP in a preclinical photophobia assay. Our finding that CGRP and PACAP monoclonal antibodies do not cross-inhibit the other peptide indicates that CGRP and PACAP actions are independent and suggests that PACAP-targeted drugs may be effective in patients who do not respond to CGRP-based therapeutics.
Decoding Concurrent Representations of Pitch and Location in Auditory Working Memory
Authors: Czoschke Stefan , Fischer Cora , Bahador Tara , Bledowski Christoph , Kaiser Jochen 
Published: April 2021

Multivariate analyses of hemodynamic signals serve to identify the storage of specific stimulus contents in working memory (WM). Representations of visual stimuli have been demonstrated both in sensory regions and in higher cortical areas. While previous research has typically focused on the WM maintenance of a single content feature, it remains unclear whether two separate features of a single object can be decoded concurrently. Also, much less evidence exists for representations of auditory compared with visual stimulus features. To address these issues, human participants had to memorize both pitch and perceived location of one of two sample sounds. After a delay phase, they were asked to reproduce either pitch or location. At recall, both features showed comparable levels of discriminability. Region of interest (ROI)-based decoding of functional magnetic resonance imaging (fMRI) data during the delay phase revealed feature-selective activity for both pitch and location of a memorized sound in auditory cortex and superior parietal lobule. The latter region showed higher decoding accuracy for location than pitch. In addition, location could be decoded from angular and supramarginal gyrus and both superior and inferior frontal gyrus. The latter region also showed a trend for decoding of pitch. We found no region exclusively coding pitch memory information. In summary, the present study yielded evidence for concurrent representations of pitch and location of a single object both in sensory cortex and in hierarchically higher regions, pointing toward representation formats that enable feature integration within the same anatomic brain regions.SIGNIFICANCE STATEMENTDecoding of hemodynamic signals serves to identify brain regions involved in the storage of stimulus-specific information in working memory (WM). While to-be-remembered information typically consists of several features, most previous investigations have focused on the maintenance of one memorized feature belonging to one visual object. The present study assessed the concurrent storage of two features of the same object in auditory WM. We found that both pitch and location of memorized sounds were decodable both in early sensory areas, in higher-level superior parietal cortex and, to a lesser extent, in inferior frontal cortex. While auditory cortex is known to process different features in parallel, their concurrent representation in parietal regions may support the integration of object features in WM.
Use of Arttherapy Techniques in Pedagogical Accompaniment of Children with Special Educational Needs
Authors: Kuzenko Petro , Kuzenko Olexandra , Matsuk Liudmyla 
Published: April 2021

The article emphasizes the fact that the problem of providing effective pedagogical support for personal development of children with mental and physical disabilities occupies an important place in the educationa theory and practice of modern Ukraine. Among scientists there are different approaches to determining its content, purpose and objectives. Most researchers consider pedagogical support of children with special educational needs (SEN) assystematic actions and measuresaime datensuring positive results in the educational process. The main tasks of pedagogical support of children with psychophysical developmental disorders are to ensure their social adaptation and over come difficulties in communicating with peers; prevention of problems of personal development and upbringing of the child; providing assistance in solving current educational problems and socialization; implementation of psychological and pedagogical counseling for parents. The authorsempha size that art therapy is rightly considered to be an effective means of pedagogical influenceon children with SEN in an inclusive educational space. Art therapy as a method of diagnosis, change and resource development of an individual, group or team through the use of different art sand their own creative activities has a wide field of application in various areas of teaching. To achieve a positive result in the pedagogical support of children with SEN the following arttherapy means are used: drawing therapy, fairy-tale therapy, sand therapy, music therapy, photo therapy, color therapy, which can be integrated, completing each other. It is scientifically proven that theuse of different types of arts contributes to the development of a child’s emotional and communicative sphere, the establishment of interpersonal communication, taking into account emotional state of peers. During art therapy classes peculiarities of interpersonal communication are revealed, obstacles in its establishment are found and over come, and as a result the development of social-communicatives kills of children with SEN.
Implementation of Transdisciplinary Approach in the Process of Formation of Future Primary School Teachers’ Communicative-Strategic Competence
Authors: Oliiar Mariia , Fomin Kateryna 
Published: April 2021

The urgency of the problem of formation of communicative-strategic competence of future primary school teachers is substantiated in the article. The importance of implementing a communicative approach in the professional training of students in terms of reforming the education system in accordance with the Concept of the New Ukrainian School is emphasized. The authors of the article emphasized the specifics of pedagogical discourse as strategically planned and aimed at achieving a certain communicative goal. The results of the survey of graduate students majoring in “Primary Education” are revealed, which proved the necessity of developing a special methodology for the formation of future teachers’ communicative-strategic competence. The essence of the transdisciplinary approach as the basis of the specified technique is revealed. The characteristics, basics and the overarching purpose of the method are given. It is substantiated that in the conditions of the organization of pedagogical discourse the purpose becomes a process of educational work, ways and methods of knowledge acquiring and mastering of skills in the specific intersubjective communicative-dialogic space created by the teacher which students join as equal participants of communication among other participants with common considering of social situation, specifics of the future profession, professional language. The communicative concepts of navigation character are defined and conceptual fields of interconnected communicative concepts for providing transdisciplinary connections are characterized. The principles of realization of the offered technique are revealed: conformity of the modeled educational process to the final purpose of future teachers’ training for work in the conditions of the communicative environment of modern primary school; taking into account specifics of future professional activity; considering psychological features of future teachers' acquisition of communicative knowledge and skills; optimal combination of theoretical knowledge and practical skills; selection of the most effective forms, methods, technologies of formation of communicative-strategic competence.
Mathematical Word Problems That Contain a Constant in the Course of Mathematics of Primary School in Ukraine
Authors: Skvortsova Svitlana , Оnoprienko Oksana , Romanyshyn Ruslana 
Published: April 2021

The article is devoted to the research of the place of the mathematical word problems in the course of mathematics of primary school in Ukraine. The researchers define the results in the study of solving math problems, find out the essence of the process of solving math problems, form primary school students’ ability to solve math problems that contain a constant. Among the mentioned are to find the fourth proportional, do the proportional division and find the unknown number by two differences. The paper deals with the organization of educational research of students in order to identify common and distinctive features of the mathematical structures of these types of math problems and their influence on the method of solution. Based on the methodological system of teaching primary school learners to solve math problems by S. Skvortsova, taking into account the essence of the concept of “ability to solve math problems” and the methodical system of forming the ability to solve certain types of math problems, it has been proposed a system of drilling activities for the generalization of mathematical structures and methods of solving math problems that contain a constant value.
EVALUATION OF ACUTE TOXICITY EXPOSURE TO AQUEOUS LEAVES EXTRACT OF SYZYGIUM KANARENSE (TALBOT) RAIZADA
Authors: CHALANNAVAR RAJU KRISHNA , S Divakar M , Debnath Souvik , Debnath Souvik , Chatterjee Tapan Kumar , Shenoy Sooryaprakash H 
Published: April 2021

Syzygium kanarense (Talbot) Raizada (Family: Myrtaceae), a rare plant tested for toxicity in order to explore therapeutic value. In the current study, the preliminary phytochemical screening, in vitro toxicity and acute toxicity of aqueous extract of Syzygium kanarense leaves (AESKL) were evaluated. Phytochemicals were screened and cytotoxicity was confirmed by MTT assay using NIH/3T3 cell line. For acute toxicity evaluation, female rats were divided into two equal groups; one group served as control while the other group received a single dose of AESKL at 2000mg/kg body weight (b.w) were treated and observed for 14 days. AESKL contains phenolics, tannins, terpenoids, saponins and steroids. The result showed the cytotoxicity value of inhibitory concentration (IC50) = 491.56 µg/ml of AESKL. Acute toxicity of AESKL established the Lethal Dose (LD50) more than 2000 mg/kg b.w and no mortality rate was observed. No changes in behavioural, b.w, relative organ weight, haematological, biochemical and histological were observed. Based on the results, it can be conclude that AESKL do not pose any risk when given orally to rats. To the best of our knowledge, this is the first report on evaluation of in vitro and in vivo toxicity of AESKL.
DESULFURIZATION OF BENZOTHIOPHENE BY AN ISOLATED GORDONIA SP. IITR100
Authors: Ahmad Dr Varish , Ahmad Abrar , Khan Mohammad Imran , Baothman Othman A.S. , Khan Mohd. Jahir 
Published: April 2021

Different recalcitrant aliphatic and aromatic sulfur compounds e.g. Dibenzothiophene, Benzothiophene, and Di-methyl Dibenzothiophene etc. have been remaining in the petrol and diesel, even after hydrodesulfurization, a chemical method of sulfur impurities removal. These sulfur impurities are required to be removed before it is being transported as fuel. So many microbes have been reported in the last decade showing potential for removing the sulfur impurities by using various pathways at ambient temperature, especially 4S pathways. In this study, we describe desulfurization of a model compound Benzothiophene by a Gordonia sp. IITR100 using microbial cell culture and analytical techniques e.g. spectrophotometry and gas chromatography-mass spectrophotometry using column-5. Gordonia sp. IITR100 can grow on Benzothiophene as well as Dibenzothiophene us shown by spectrophotometrical analysis as evident by increased turbidity in aqueous culture. Benzothiophene was metabolized to o-hydroxystyrene as the final product analogous to ‘4S’ pathway as Gas Chromatography-Mass Spectra analysis revealed. Gordonia sp. IITR100 have already been shown desulfurization with heavy organosulfur compounds like Thianthrene, and Benzonahpthothiophene to o-hydroxyphenyl phenylsulfone and 2-phenyl-naphthalene-1-ol respectively. The Gordonia sp. IITR100 have shown potential for Desulfurization of heavy and calcitarant sulfur-compounds suggests its potential (broad substrates range) for use in various tough organosulfur fractions in petroleum. Thus, this bacterial strain could be utilized for commercial purpose of biodesulfurization.
Yeni Savaş Ortamında Eski Bir Aktör: Yabancı Terörist Savaşçılar ve Yeni Çatışmalardaki Rolleri
Authors: ÇONA Ömer 
Published: April 2021

Vatandaşı olmadığı devletlerin ordularında çeşitli saiklerle savaşan kişilerin yarattığı yabancı savaşçılık fenomeni, günümüzde değişen motivasyonlarla sürmektedir. Savaşlar ise amaçsal düzeyde aynı kalmakla birlikte araç, süre, biçim ve aktörlerinde değişiklik arz eden bir yapıya bürünmüştür. Kuvvet kullanma tekelinin giderek devlet dışı aktörlerle paylaşıldığı bir dünyada savaşlar, devletler arası seviyeden hızla devlet içi düzeye doğru evrilmektedir. Böylece yeni savaş ortamında düzenli ordular yerine yabancı terörist savaşçılar, paralı askerler ve özel askerî şirket elemanları gibi devlet dışı silahlı aktörlerin görünürlüğü giderek artmaktadır.
Bu çalışmada, savaşların değişen doğası içerisinde yabancı savaşçıların üstlendiği roller analiz edilmeye çalışılmıştır. Bu maksatla savaşın değişimi ve yabancı savaşçılık konusuyla ilgili kaynaklar incelenmiş ve bunların analizinde tarihsel-betimleyici bir yöntem benimsenmiştir. Sonuç kısmında ise yeni savaş ortamıyla birlikte, geleneksel yabancı savaşçılık olgusunun da dönüşüme uğrayarak vekâlet savaşı, terörizm ve ayaklanma hareketi gibi asimetrik savaş ortamı ile bütünleştiği hususunda elde edilen bulgular ortaya konulmaya çalışılmıştır.
Luminescent properties of colloidal mixtures of Zn0.5Cd0.5S quantum dots and gold nanoparticles
Authors: Ovchinnikov Oleg V. , Smirnov Mikhail S. , Grevtseva Irina G. , Derepko Violetta N. , Chevychelova Tamara A. , Leonova Liana Yu. , Perepelitsa Aleksey S. , Kondratenko Tamara S. 
Published: April 2021

The aim of the study is to establish spectral-luminescent interaction effects in mixtures of colloidal Zn0.5Cd0.5S quantum dots passivated with 2-mercaptopropionic acid and Au and Au/SiO2nanoparticles. The studied samples of Zn0.5Cd0.5S quantum dots, Au and Au/SiO2 nanoparticles and their mixtures were obtained by methods of colloidal synthesis and were characterised using transmission electron microscopy. The absorption, luminescence and time-resolved luminescence spectroscopy were used as the main investigation methods. The measurements were carried out at temperatures of 77 K and 300 K. The spectral-luminescent properties of “free” Zn0.5Cd0.5S quantum dots and those interacting with Au and Au/SiO2 nanoparticles were compared. It was found that the luminescence properties of Zn0.5Cd0.5S quantum dots can be controlled under conditions of changing plasmon-exciton coupling achieved during the formation of a dielectric SiO2 shell on the surface of Au nanoparticles as well as a result of a polymer introduced into the colloidal mixture.
A NOTE ON ΑIG- CLOSURE AND ΑIG- INTERIOR IN IDEAL TOPOLOGICAL SPACES
Authors: Et. al. D. Vinodhini, 
Published: April 2021

The concepts of αIg- closure, αIg- interior and αIg- boundary of a subset of an ideal topological space (X, t, I) are introduced in this article. Some of their basic properties are proven. Furthermore, the relationships between these sets are investigated to get the best of them. Also, it is established that αIg- closure is a Kuratowski closure operator on (X, t, I) under certain conditions.
WORK FROM HOME AT IT COMPANIES– THE NEW NORMAL
Authors: Et. al. Dr. S. Seethalakshmi , 
Published: April 2021

Work from Home” has become the new normal during theCovid’19 pandemic. The Information Technology giants companies are considering ‘Work from home’ as a permanent solution to the increasing rental costs and overhead costs. Work from home has not affected the productivity of the employees in most cases. IT Employees also stand to benefit in many ways in terms of flexible working, reduced travel, home atmosphere, less pollution etc.
This study was taken up through a survey of 103 IT employees to understand their perception on ‘Work from Home’. The study intends to identify Factors influencing their perception and the Challenges faced by them during work from home.
A Study to Analyze the Impact of Knowledge Management (KM) practices in IT Service Delivery Industry in India
Authors: Et. al. Barakath Ali Shaik Mohamed, 
Published: April 2021

Information Technology (IT) Industry in India is growing fast. Organizations across the world are outsourcing the IT services to take advantage of cost and time differences. India plays vital role in supporting the outsourcing services by taking advantage of the language skills and skilled workforce. Knowledge Management (KM) is critical for the continuity of the services and success of the organisations in different domains. This paper analysis the impact of Knowledge Management in Information Technology (IT) Service Delivery Industry in India. The study reveals Knowledge Management improves the performance of the Service Delivery organization. Methodical implementation and continuous improvement of Knowledge Management practices would further accelerate and improve the customer experience.
Vertex Magic Labeling On V_4 for Cartesian product of two cycles
Authors: Et. al. Dr. V. L.Stella Arputha Mary, 
Published: April 2021

Let be an abelian group under multiplication. Let . Then the vertex magic labeling on is induced as such that where the product is taken over all edges of incident at is constant. A graph is said to be - magic if it admits a vertex magic labeling on . In this paper, we prove that , , Generalized fish graph, Double cone graph and four Leaf Clover graph are all -magic graphs.
Mathematic Model Design Of Solar Pumping For Drip Irrigation Systems
Authors: Et. al. Mhamdi Hicham, 
Published: April 2021

The use of solar energy in isolated sites for different applications, such as water pumping, is of primary interest to people in developing countries who do not have safe access to water drinking. But photovoltaic generators have two major drawbacks that are a low yield and a high blow. In order to increase the performance of these systems. Proper adaptation between the solar generator and the load reduces the cost of installation. The choice of an energy system must obey and comply with certain rules. The selected energy system must show as a preliminary its competitiveness with respect to other systems for the same rendered service. The present study have a propose the modeling, simulation, sizing and realization of a photovoltaic pumping system operating over the sun. This system consists of a set of interacting elements; namely the photovoltaic panels, the voltage inverter, the asynchronous motor, the centrifugal pump and the hydraulic circuit.
Inherent Presence Of Children In Society "Proposed Criteria And Indicators."
Authors: Et. al. Nermeen Singer, 
Published: April 2021

This study shows that achieving the child's inherent presence is a vital requirement for a life he deserves, as the child's inherent existence is the extent to which the child gets a sense of satisfaction with life. This is according to key components such as integration in mutual relationships and opportunities to develop life skills and develop children's right to express their views and create a healthy and child-friendly climate.
The research supports enabling early childhood professionals to work together with children's families to achieve common outcomes for all children. Promote all learning and development outcomes. The results confirm the importance of sensitive practice and responding to children's desires and need to support their real presence in society.
The study resulted in indicators and practices carried out by the child and his teachers in all five areas of the feeling of original existence which are developing children's strong sense of identity, developing children's connection to and participation in their world, improving children's sense of personal happiness, development and improvement of self-confidence in children, and developing and refining effective dialogue with children.
The novelty of the study is shown from the achieving the child's original existence is a vital requirement for a life he deserves, as the child's original presence is that extent to which the child gets a sense of satisfaction with life according to key ingredients such as integration in mutual relationships and opportunities to develop life skills and develop children's right to express their own views Create a healthy environment for children.