bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of relationship-based interventions for maltreated children and adolescents: a systematic review and meta-analysis
Authors: Bergsund Hans Bugge , Drozd Filip , Olafsen Kåre S. , Nilsen Karianne Hammerstrøm , Linnerud Siv , Kjøbli John , Jacobsen Heidi 
Published: November 2021

AbstractChild maltreatment is characterized by a harmful relational environment which can have negative cascading consequences for the child’s development. Relationship-based interventions may improve maltreated children’s functioning by addressing key aspects of the parent-child relationship at various stages of development. The objective of the current study was to perform a systematic review on relationship-based interventions for maltreated children and a meta-analysis on the impact of these interventions on observed parent-child relational behavior. Data collection consisted of a comprehensive literature search in six databases and contacting experts in the field and hand searching relevant publications. In total, 5,802 abstracts were screened, of which 81 relevant publications were identified, representing 4,526 participants. The meta-analysis found large improvements in observed parent interactive behavior (g = 0.888), smaller improvements in child attachment (g = 0.403) and child interactive behavior (g = 0.274). The effect on parent interactive behavior was larger in interventions addressing middle childhood. Risk of bias assessments showed that a large number of studies suffer from poor reporting, which limits the conclusions of the findings. Future research should examine parent-child relationship behavior across multiple developmental stages, as well as the impact of developmentally appropriate intervention elements on maltreated children.
Surgical outcome of Yasui procedure for preserving biventricular function: single centre experience
Authors: Alhadi Omar , Kabbani Mohamed S. , Alhabshan Fahad , Alamer Mohammed , Alomrani Ahmed , Hamadah Hussam 
Published: November 2021

AbstractBackground:Yasui procedure is surgical repair intended to preserve biventricular function for patients with left ventricle outflow tract obstruction associated with aortic arch lesions and ventricular septal defect.Methods:Retrospective chart review analysis of all patients who had Yasui procedure (2008–2020) comparing midterm outcome of one versus two stage repair.Results:Twenty patients (70% female) underwent Yasui procedure in our center. Eight patients (40%) had left ventricle outflow tract obstruction /interrupted aortic arch, 7 patients (35%) had left ventricle outflow tract obstruction /coarctation of aorta, 3 patients (15%) had double outlet ventricle and ventricular septal defect that were unattainable for tunneling to one of the semilunar valves without creating obstruction, and 2 patients (10%) had aortic atresia with hypoplastic aortic arch. All patients had associated ventricular septal defect. Fifteen patients (75%) had one-stage repair and 5 patients (25%) had two-stage repair. Means age and weight for one and two-stage repair were 1.3 ± 2 months, 13.4 ± 11.5 months and 3.3 ± 0.6 kg, 7.8 ± 3.4 kg, respectively. During follow up, 8 patients (40%) required re- intervention, mainly for right ventricle–pulmonary artery conduit either dilation or replacement. The average duration of follow up was 5 years with nil mortality.Conclusion:Yasui procedure is effective approach for children who have left ventricle outflow tract obstruction associated with aortic arch anomalies and ventricular septal defect. Survival rate with single or staged repair is comparably good. During the first 5 year of follow up, nearly 40% of operated patients required re-intervention.
Examining the trade-offs of palm oil production and consumption from a sustainable diets perspective: lessons learned from Myanmar
Authors: Downs Shauna M , Nicholas Khristopher , Khine Linn Kay , Fanzo Jessica 
Published: November 2021

AbstractObjective:The aim of this study was to examine the trade-offs related to the production and consumption of palm oil in Myanmar from a sustainable diets perspective.Design:We used an enhanced value chain analysis approach that included semi-structured interviews with key stakeholders; market analyses to assess edible oils in markets and focus groups as well as surveys with consumers to ascertain their perceptions and practices related to edible oils.Setting:Four settings in Myanmar (upper income urban; lower income urban; middle-income urban; lower income rural).Participants:Key stakeholders (n 12) from government, trade bodies and civil society organisations were included in the interviews. Women from each of the regions participated in four focus groups (n 32), and a convenience sample of male and female consumers participated in the surveys (n 362).Results:We found mistrust of the oil sector overall. Poor production practices, leading to low yields, limit the economic viability of oil palm production in Myanmar and contribute to negative environmental (e.g. deforestation) and social outcomes (e.g. land conflicts). Consumers demonstrated low preferences for palm oil as compared with traditional oils from a taste, health and transparency perspective; however, they indicated that its relative low cost led to its purchase over other oils.Conclusions:The Burmese example suggests that there may be limited benefits, and significant costs, of investing in palm oil production in regions where there are coordinating disincentives from a sustainable diets perspective. However, if oil palm cultivation is to continue, there are opportunities to improve its economic viability and environmental sustainability.
A qualitative study of mothers’ health literacy related to malnutrition in under 5-year-old children in southern Mozambique
Authors: Lindberg Leona , Nhambongo Inocência , Nhampossa Tacilta , Munguambe Khátia , Priebe Gunilla 
Published: November 2021

AbstractObjective:To explore mothers’ perceptions of malnutrition and its causes in U-5’s in Mozambique, as well as their ability to recognise, prevent and act on signs of malnutrition.Design:A qualitative exploratory inquiry using focus group discussions and individual interviews analysed using Nutbeam’s health literacy themes.Setting:Manhiça District Hospital in Manhiça, Mozambique.Participants:Mothers of U-5’s (n 53) attending the in- and out-patient paediatric wards.Results:Different malnutrition literacy levels were identified in mothers’ responses. Mothers’ reflections on the causes of malnutrition in U-5’s were more elaborate compared to those of recognition, prevention and treatment strategies. Only severe forms of acute malnutrition were recognised by mothers, while early signs of undernutrition and stunting largely went undetected or unmentioned. Limited knowledge, time and financial resources were mentioned as contributors to suboptimal practices resulting in malnutrition. The district hospital, rather than community resources or local health posts, was indicated as the place mothers would go to seek advice and treatment for malnutrition. All mothers requested additional information on how to prevent and treat malnutrition.Conclusions:The varying literacy levels among mothers, the lack of references to community health workers as a resource in identifying and managing malnutrition, and the identification of poverty and sociocultural conditions as contributors to suboptimal practices indicate the need for in-depth research focused on the social determinants of malnutrition. A more comprehensive understanding of mothers’ health literacy would contribute to the development of holistic programmes aiming to improve community management of malnutrition.
Divorce after breast cancer diagnosis and its impact on quality of life
Authors: Kang Danbee , Kim Nayeon , Han Gayeon , Kim Sooyeon , Kim Hoyoung , Lim Jihyun , Kim Hyunsoo , Shim Sungkeun , Lee Mangyeong , Lee Jeong Eon , Nam Seok Jin , Kim Seok Won , Yu Jonghan , Lee Se Kyung , Cho Juhee 
Published: November 2021

AbstractObjectiveThis study aims to identify factors associated with divorce following breast cancer diagnosis and measures the impact of divorce on the quality of life (QoL) of patients.MethodsWe used cross-sectional survey data collected at breast cancer outpatient clinics in South Korea from November 2018 to April 2019. Adult breast cancer survivors who completed active treatment without any cancer recurrence at the time of the survey (N = 4,366) were included. The participants were classified into two groups: “maintaining marriage” and “being divorced,” between at the survey and at the cancer diagnosis. We performed logistic regression and linear regression to identify the factors associated with divorce after cancer diagnosis and to compare the QoL of divorced and nondivorced survivors.ResultsApproximately 11.1/1,000 of married breast cancer survivors experienced divorce after cancer diagnosis. Younger age, lower education, and being employed at diagnosis were associated with divorce. Being divorced survivors had significantly lower QoL (Coefficient [Coef] = −7.50; 95% CI = −13.63, −1.36), social functioning (Coef = −9.47; 95% CI = −16.36, −2.57), and body image (Coef = −8.34; 95% CI = −6.29, −0.39) than survivors who remained married. They also experienced more symptoms including pain, insomnia, financial difficulties, and distress due to hair loss.ConclusionIdentifying risk factors of divorce will ultimately help ascertain the resources necessary for early intervention.
Elitism in Democracy
Authors: Graves Stephen 
Published: November 2021

AbstractThe concept of the common good represents those resources that are good for an entire group as a whole, or what preserves what the people or inhabitants of the national community have in common. The “good” are those things that benefit the community as a whole; lead to the protection, sustainment, and improvement of the community. Theorists agree that it is the ultimate end of government; the good of all its citizens and void of special interests. Theories of the common good are discussed in this paper with implications regarding the shortcomings of democratic political institutions and structures. The theoretical framework provided by the political thought of W. E. B. Du Bois and Friedrich Nietzsche are used to critically examine the idea of the common good in contemporary democratic societies. Du Bois sought an objective truth that could dispel once and for all the irrational prejudices and ignorances that stood in the way of a just social order for African Americans. Nietzsche’s political theory was primarily concerned with disdain for democracy and the need for Aristocratic forms and social ordering. He was skeptical that with the demise of religion, it would be possible to achieve an effective normative consensus in society at large which is needed to legitimize government authority. Both theorists agree that the exceptional and great individuals are few in society and should govern in favor of the masses. Based on their example, this paper argues that both authors are suggesting an Epistocratic form of government where those with political knowledge are privileged.
A pilot practice-based outcomes evaluation of low-intensity cognitive behavioural interventions delivered by postgraduate trainees to children and young people with mild to moderate anxiety or low mood: an efficient way forward in mental health care?
Authors: Lockhart Gavin , Jones Christina , Sopp Victoria 
Published: November 2021

AbstractAnxiety and depression affect a significant number of children and young people (CYP) and can have a far reaching and long-lasting impact. Cognitive behavioural (CB) interventions can be effective for treating anxiety and depression in CYP but are difficult to access. Recent government policy in England seeks to train a non-traditional graduate workforce to deliver a range of CB interventions for mild to moderate anxiety and depression to CYP, in community settings. This practice-based evaluation aimed to estimate the effectiveness of CB interventions delivered by postgraduate trainees undertaking training in a range of CB interventions for mild to moderate anxiety and depression whilst on placement in schools or community Child and Adolescent Mental Health Services (CAMHS). Self- and parent-reported routine outcome measures (ROMS) were completed pre- and post-intervention, including measures of symptom severity, symptom impact and goal achievement. Significant improvements were demonstrated across all self and parent-reported measures post-intervention, with mean scores falling firmly in the non-clinical range, a significant reduction in the proportion of CYP in the clinical range on measures, and predominantly medium to large effect sizes. Results are promising in terms of the capacity to train a graduate workforce to deliver a range of low-intensity CB interventions to CYP experiencing mild to moderate depression or anxiety-based difficulties in either CAMHS or school settings, increasing capacity across the system. The current practice-based evaluation also supports the potential effectiveness of current training models/programmes. Further research is needed in terms of long-term outcomes and to compare outcomes between settings, interventions, and demographic groups.Key learning aims(1)To understand the potential prevalence rates of mental health difficulties in children and young people in England, and their wider impact.(2)Critical awareness of the evidence base for cognitive and behavioural interventions for depression and anxiety in children and young people.(3)Awareness of gaps in access to evidence-based psychological interventions for children and young people in England.(4)Knowledge of emerging graduate-level low-intensity psychological practitioner roles in England.(5)Awareness of the emerging evidence base for the estimated effectiveness of low-intensity cognitive and behavioural interventions delivered to children and young people by graduate-level practitioners in schools and community mental health settings.
Predicting Thermal Responses of an Arctic Lake to Whole‐Lake Warming Manipulation
Authors: Zhang Qunhui , Jin Jiming , Budy Phaedra , Null Sarah E. , Wang Xiaochun , Pennock Casey A. 
Published: November 2021

AbstractWe investigated how lake thermal processes responded to whole lake warming manipulation in an arctic lake through observations and numerical modeling. The warming manipulation was conducted by artificially heating the epilimnion as a proxy for climate warming. We performed numerical modeling with an improved lake scheme based on the Community Land Model (CLM). We simulated a control run (CTL) without warming and a warming manipulation simulation (WARM). Results indicated WARM accurately captured observed temperatures where water stratification was extended in time, and water stability was strengthened. Two additional sensitivity tests with different warming onset dates and of the same warming duration showed that earlier warming onsets are predicted to make the water column more stable and less easily mixed relative to a later onset of warming. The results provide a more complete understanding of lake thermal processes in arctic freshwater lake systems and how they will respond to predicted future warming.
Rapid Freshening of Iceland Scotland Overflow Water Driven by Entrainment of a Major Upper Ocean Salinity Anomaly
Authors: Devana Manish S. , Johns William E. , Houk Adam , Zou Sijia 
Published: November 2021

AbstractNewly available mooring observations from the Overturning in the Subpolar North Atlantic Program (OSNAP) show an abrupt decline in Iceland Scotland Overflow (ISOW) salinity from 2017 to 2018 summer. Previous declines in ISOW salinity of similar magnitude have largely been attributed to changes in convectively formed deep waters in the Nordic Seas on decadal time scales. We show that this rapid decline in salinity was driven by entrainment of a major upper ocean salinity anomaly in the Iceland Basin. This is shown by tracking the propagation of the upper ocean anomaly into ISOW using a combination of mooring and Argo observations, surface drifter trajectories, and numerical model results. A 2‐year total transit time from the upper ocean into the ISOW layer was found. The results show that entrainment allows for rapid modification of ISOW, and consequently the lower limb of Atlantic Meridional Overturning Circulation, on subdecadal timescales.
Simulations With the Marine Biogeochemistry Library (MARBL)
Authors: Long Matthew C. , Moore J. Keith , Lindsay Keith , Levy Michael , Doney Scott C. , Luo Jessica Y. , Krumhardt Kristen M. , Letscher Robert T. , Grover Maxwell , Sylvester Zephyr T. 
Published: November 2021

AbstractThe Marine Biogeochemistry Library (MARBL) is a prognostic ocean biogeochemistry model that simulates marine ecosystem dynamics and the coupled cycles of carbon, nitrogen, phosphorus, iron, silicon, and oxygen. MARBL is a component of the Community Earth System Model (CESM); it supports flexible ecosystem configuration of multiple phytoplankton and zooplankton functional types; it is also portable, designed to interface with multiple ocean circulation models. Here, we present scientific documentation of MARBL, describe its configuration in CESM2 experiments included in the Coupled Model Intercomparison Project version 6 (CMIP6), and evaluate its performance against a number of observational data sets. The model simulates present‐day air‐sea CO2 flux and many aspects of the carbon cycle in good agreement with observations. However, the simulated integrated uptake of anthropogenic CO2 is weak, which we link to poor thermocline ventilation, a feature evident in simulated chlorofluorocarbon distributions. This also contributes to larger‐than‐observed oxygen minimum zones. Moreover, radiocarbon distributions show that the simulated circulation in the deep North Pacific is extremely sluggish, yielding extensive oxygen depletion and nutrient trapping at depth. Surface macronutrient biases are generally positive at low latitudes and negative at high latitudes. CESM2 simulates globally integrated net primary production (NPP) of 48 Pg C yr−1 and particulate export flux at 100 m of 7.1 Pg C yr−1. The impacts of climate change include an increase in globally integrated NPP, but substantial declines in the North Atlantic. Particulate export is projected to decline globally, attributable to decreasing export efficiency associated with changes in phytoplankton community composition.
KRAS mutation: from undruggable to druggable in cancer
Authors: Huang Lamei , Guo Zhixing , Wang Fang , Fu Liwu 
Published: November 2021

AbstractCancer is the leading cause of death worldwide, and its treatment and outcomes have been dramatically revolutionised by targeted therapies. As the most frequently mutated oncogene, Kirsten rat sarcoma viral oncogene homologue (KRAS) has attracted substantial attention. The understanding of KRAS is constantly being updated by numerous studies on KRAS in the initiation and progression of cancer diseases. However, KRAS has been deemed a challenging therapeutic target, even “undruggable”, after drug-targeting efforts over the past four decades. Recently, there have been surprising advances in directly targeted drugs for KRAS, especially in KRAS (G12C) inhibitors, such as AMG510 (sotorasib) and MRTX849 (adagrasib), which have obtained encouraging results in clinical trials. Excitingly, AMG510 was the first drug-targeting KRAS (G12C) to be approved for clinical use this year. This review summarises the most recent understanding of fundamental aspects of KRAS, the relationship between the KRAS mutations and tumour immune evasion, and new progress in targeting KRAS, particularly KRAS (G12C). Moreover, the possible mechanisms of resistance to KRAS (G12C) inhibitors and possible combination therapies are summarised, with a view to providing the best regimen for individualised treatment with KRAS (G12C) inhibitors and achieving truly precise treatment.
A novel cytokine consisting of the p40 and EBI3 subunits suppresses experimental autoimmune arthritis via reciprocal regulation of Th17 and Treg cells
Authors: Lee Seon-Yeong , Moon Su-Jin , Moon Young-Mee , Seo Hyeon-Beom , Ryu Jun-Geol , Lee A Ram , Lee Chae Rim , Kim Da-Som , Her Yang-Mi , Choi Jeong Won , Kwok Seung-Ki , Park Sung-Hwan , Cho Mi-La 
Published: November 2021

AbstractObjectiveThe interleukin (IL)-12 cytokine family is closely related to the development of T helper cells, which are responsible for autoimmune disease enhancement or suppression. IL-12 family members are generally heterodimers and share three α-subunits (p35, p19, and p28) and two β-subunits (p40 and EBI3). However, a β-sheet p40 homodimer has been shown to exist and antagonize IL-12 and IL-23 signaling1. Therefore, we assumed the existence of a p40-EBI3 heterodimer in nature and sought to investigate its role in immune regulation.MethodsThe presence of the p40-EBI3 heterodimer was confirmed by ELISA, immunoprecipitation, and western blotting. A p40-EBI3 vector and p40-EBI3-Fc protein were synthesized to confirm the immunological role of this protein in mice with collagen-induced arthritis (CIA). The anti-inflammatory effects of p40-EBI3 were analyzed with regard to clinical, histological, and immune cell-regulating features in mice with CIA.ResultsClinical arthritis scores and the expression levels of proinflammatory cytokines (e.g., IL-17, IL-1β, IL-6, and TNF-α) were significantly attenuated in p40-EBI3-overexpressing and p40-EBI3-Fc-treated mice with CIA compared to vehicle-treated mice with CIA. Structural joint damage and vessel formation-related gene expression were also reduced by p40-EBI3 heterodimer treatment. In vitro, the p40-EBI3-Fc protein significantly suppressed the differentiation of Th17 cells and reciprocally induced CD4+CD25+Foxp3+(regulatory T) cells. p40-EBI3 also inhibited osteoclast formation in a concentration-dependent manner.ConclusionIn this study, p40-EBI3 ameliorated proinflammatory conditions both in vivo and in vitro. We propose that p40-EBI3 is a novel anti-inflammatory cytokine involved in suppressing the immune response through the expansion of Treg cells and suppression of Th17 cells and osteoclastogenesis.
Attitudes among parents of persons with autism spectrum disorder towards information about genetic risk and future health
Authors: Johannessen Jarle , Nærland Terje , Hope Sigrun , Torske Tonje , Kaale Anett , Wirgenes Katrine V. , Malt Eva , Djurovic Srdjan , Rietschel Marcella , Andreassen Ole A. 
Published: November 2021

AbstractClinical relevance of genetic testing is increasing in autism spectrum disorder (ASD). Information about genetic risk may contribute to improved diagnostics, treatment and family planning, but may also be perceived as a burden. Knowledge about the families’ preferences with regard to genetic risk information is important for both health care professionals and policy makers. We investigated attitudes towards sharing information about genetic risk of ASD and knowledge about future health among parent members of the Norwegian Autism Association (N = 1455) using a questionnaire, and the relationships with parent and child characteristics, such as age, gender and ASD severity. Most preferred autonomy in deciding whom to inform about genetic risk of ASD (74.4%) and a minority supported extensive intra-familial disclosure of the genetic risk (41.1%). The majority agreed that it is an obligation to know as much as possible relevant for future health (58.0%) and only 51.7% agreed to a principle of a ‘right not to know’. In regression models, the attitudes were associated with opinions about benefits and harms of genetic testing (e.g., treatment, family planning, understanding of ASD pathology, insurance discrimination and family conflict). In sum, the findings show that most parents want to know as much as possible relevant for their children’s future health and keep their autonomy and intra-familial confidentiality about genetic risk information. Nearly half of the parents were not concerned with a “right not to know”. These attitudes can inform development of guidelines and bioethics in the age of genomic precision medicine.