bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Semiotika Iklan Gojek #Gakpakelama dan Iklan Grab #Antingaret pada Layanan Transportasi Online di Indonesia
Authors: Almanfaluthi Betha , Juniar Juniar 
Published: October 2021

AbstrakGojek dan Grab adalah salah satu perusahaan jasa online terbesar di Indonesia. Baik Gojek maupun Grab memiliki banyak jenis jasa yang ditawarkan, akan tetapi transportasi menjadi jasa utama keduanya. Kondisi jalanan di kota-kota besar di Indonesia khususnya Jakarta yang sering mengalami kemacetan, menjadikan kendaraan roda dua menjadi alternatif berkendara yang populer. Sebagai dua perusahaan transportasi online yang memiliki layanan dan sasaran konsumen yang sama sehingga dalam membuat iklan Gojek dan Grab ada kecenderungan memiliki pesan yang sama dan tema yang mirip namun juga terlihat berbeda. Kajian ini bertujuan untuk menganalisa makna iklan kampanye #gakpakelama oleh Gojek dan #antingaret oleh Grab dengan mengurai tanda-tanda visual untuk melihatkan perbedaan antar kedua layanan transportasi online tersebut. Penelitian dilakukan dengan metode analisis isi yang dikombinasikan dengan pendekatan semiotika Roland Barthes yang menganalisis perluasan makna tanda. Dari hasil analisis didapatkan bahwa pengguna transportasi online digambarkan sebagai pekerja kantoran usia muda yang butuh solusi berupa layanan transportasi online yang siap kapan pun sebagai sebuah solusi yang dapat membantu orang-orang berjuang menghadapi kehidupan pekerjaan di kota besar terkait waktu. Kata Kunci: analisis isi, gojek, grab, iklan, semiotika AbstractGojek and Grab are some of the largest online service companies in Indonesia. Both Gojek and Grab have various types of services, but transportation is the primary service. Road conditions in big cities in Indonesia, especially Jakarta, often experience traffic jams so that two-wheeled vehicles are a popular alternative to driving. As two online transportation companies have the same services and target consumers, Gojek and Grab advertisements tend to have the same message and similar themes but also look different. This study purpose to analyze the meaning of the #gakpakelama by Gojek and #antingaret by Grab campaign advertisements by parsing visual signs to show the distinctions between the two online transportation services. The research was conducted using the content analysis method combined with the semiotic approach of Roland Barthes that analyzed the expansion of the meaning of the sign. From the analysis of the results, it was found that online transportation users are described as young office workers who need solutions in the form of online transportation services that are ready at any time as a solution that can help people struggle with working life in big cities related to time. Keywords: campaign, content analysis, gojek, grab, semiotic
Kajian Semiotika Tokoh Tawang Alun pada Komik Wayang Beber Pacitan Adegan Ketiga Belas
Authors: Margana Margana 
Published: October 2021

AbstrakWayang beber Pacitan merupakan jenis seni tradisi asli Nusantara yang unik dan langka, tetapi keberadaannya saat ini hampir punah karena tergeser oleh budaya modern. Jenis wayang tersebut mengangkat cerita Panji dengan beberapa tokoh yang memiliki sifat dan karakter beragam. Penelitian ini bertujuan untuk menganalisis karakter tokoh Tawang Alun pada adegan ketiga belas wayang beber Pacitan. Penelitian ini termasuk jenis penelitian deskriptif kualitatif. Data penelitian dikumpulkan melalui observasi, wawancara, dan analisis dokumen. Pengambilan sampel penelitian dengan cara purposive sampling. Data penelitian dianalisis dengan metode analisis interaktif dan menggunakan teori semiotika. Untuk mengetahui validitas data digunakan triangulasi. Kesimpulan penelitian adalah Tawang Alun sebagai tokoh utama pada adegan ketiga belas wayang beber Pacitan memiliki karakter kuat yaitu setia pada atasan, rela berkorban dan penuh dedikasi dalam menjalankan tugasnya. Kata kunci: adegan, karakter, komik, semiotika, wayang beber AbstractWayang Beber Pacitan is a unique and rare piece of traditional art from Indonesia, but its existence is presently almost extinct because it was shifted by modern culture. This type of wayang raises the of Panji with several characters who have various traits and characters. This study aims to analyze the characters of Tawang Alun in the 13th scene of Pacitan’s wayang Beber. This research is qualitative descriptive, research data was collected through observation, interviews, and document analysis. The research sample was taken by purposive sampling. The research data were analyzed by interactive analysis method and using semiotic theory. To determine the validity of the data used triangulation. The study concludes that Tawang Alun is the main character in the thirteenth scene of Pacitan’s wayang Beber and it has a strong character that is loyal to his superiors, willing to sacrifice, and full of dedication in carrying out his duties. Keywords: character, comic, semiotic, scene, wayang beber
Clinical Value of the Lactate/Albumin Ratio and Lactate/Albumin Ratio × Age Score in the Assessment of Prognosis in Patients With Sepsis
Authors: Chen Xiaonan , Zhou Xinjian , Zhao Hui , Wang Yanxue , Pan Hong , Ma Ke , Xia Zhijie 
Published: October 2021

Objective: To examine the clinical significance of the blood lactate (Lac)/serum albumin (Alb) ratio and the Lac/Alb × age score for assessing the severity and prognosis of patients with sepsis.Methods: A total of 8,029 patients with sepsis, aged &gt;18 years were enrolled between June 2001 to October 2012 from the latest version of the Medical Information Mart for Intensive Care III (MIMIC-III v.1.4). The general data of the patients were obtained from hospital records and included gender, age, body mass index (BMI), laboratory indices, the sequential organ failure assessment (SOFA) score, and simplified acute physiology score II (SAPS II). The patients were graded and scored according to their age and then divided into a survival or death group based on their prognosis. The Lac/Alb ratio after ICU admission was calculated and compared between the two groups. The risk factors for death in patients with sepsis were determined using multivariate logistic regression analysis, while mortality was examined using receiver operating characteristic (ROC) curve and survival curve plots. Finally, the values of the Lac/Alb ratio and Lac/Alb × age score for assessing prognosis of patients with sepsis were analyzed and compared.Results: After items with default values were excluded, a total of 4,555 patients with sepsis were enrolled (2,526 males and 2,029 females). 2,843 cases were classified as the death group and 1,712 cases in the survival group. (1) The mean age, BMI, SOFA and SAPS II scores were higher in the death group than those in the survival group. Significant differences in baseline data between the two groups were also observed. (2) The patients in the death group were divided further into four subgroups according to the quartile of the Lac/Alb ratio from low to high. Comparison of the four subgroups showed that the death rate rose with an increase in the Lac/Alb ratio, while analysis of the survival curve revealed that patients with a higher Lac/Alb ratio had a worse prognosis. (3) Multivariate logistic regression analysis showed that age ≥ 60 years, overweight (BMI ≥ 24 kg/m2), Lac/Alb ratio ≥ 0.16, SOFA score ≥ 2 points, and SAPS II ≥ 40 points were independent risk factors for death in patients with septic. (4) ROC curve analysis indicated that the SAPS II, Lac/Alb x age score, SOFA, and Lac/Alb ratio were the best predictors of death in patients with sepsis. The Lac/Alb × age score was characterized by its simple acquisition and ability to quickly analyze the prognosis of patients.Conclusion: (1)A high Lac/Alb ratio is an independent risk factor for death in patients with sepsis. (2) Although the prognosis of sepsis can be accurately and comprehensively assessed by multi-dimensional analysis of multiple indices, the Lac/Alb×age score is more accurate and convenient for providing a general assessment of prognosis, so is worthy of further clinical recognition.
Intermediate- vs. Standard-Dose Prophylactic Anticoagulation in Patients With COVID-19 Admitted in Medical Ward: A Propensity Score-Matched Cohort Study
Authors: Smadja David M. , Bonnet Guillaume , Gendron Nicolas , Weizman Orianne , Khider Lina , Trimaille Antonin , Mirault Tristan , Fauvel Charles , Diehl Jean-Luc , Mika Delphine , Philippe Aurelien , Pezel Théo , Goudot Guillaume , Sutter Willy , Planquette Benjamin , Waldmann Victor , Sanchez Olivier , Cohen Ariel , Chocron Richard 
Published: October 2021

Background:Microthrombosis and large-vessel thrombosis are the main triggers of COVID-19 worsening. The optimal anticoagulant regimen in COVID-19 patients hospitalized in medical wards remains unknown.Objectives:To evaluate the effects of intermediate-dose vs. standard-dose prophylactic anticoagulation (AC) among patients with COVID-19 hospitalized in medical wards.Methods and results:We used a large French multicentric retrospective study enrolling 2,878 COVID-19 patients hospitalized in medical wards. After exclusion of patients who had an AC treatment before hospitalization, we generated a propensity-score-matched cohort of patients who were treated with intermediate-dose or standard-dose prophylactic AC between February 26 and April 20, 2020 (intermediate-dose,n= 261; standard-dose prophylactic anticoagulation,n= 763). The primary outcome of the study was in-hospital mortality; this occurred in 23 of 261 (8.8%) patients in the intermediate-dose group and 74 of 783 (9.4%) patients in the standard-dose prophylactic AC group (p= 0.85); while time to death was also the same in both the treatment groups (11.5 and 11.6 days, respectively,p= 0.17). We did not observe any difference regarding venous and arterial thrombotic events between the intermediate dose and standard dose, respectively (venous thrombotic events: 2.3 vs. 2.4%, p=0.99; arterial thrombotic events: 2.7 vs. 1.2%,p= 0.25). The 30-day Kaplan–Meier curves for in-hospital mortality demonstrate no statistically significant difference in in-hospital mortality (HR: 0.99 (0.63–1.60);p= 0.99). Moreover, we found that no particular subgroup was associated with a significant reduction in in-hospital mortality.Conclusion:Among COVID-19 patients hospitalized in medical wards, intermediate-dose prophylactic AC compared with standard-dose prophylactic AC did not result in a significant difference in in-hospital mortality.
More Than Just Static: Dynamic Functional Connectivity Changes of the Thalamic Nuclei to Cortex in Parkinson's Disease With Freezing of Gait
Authors: Wang Shangpei , Cai Huanhuan , Cao Zong , Li Chuan , Wu Tong , Xu Fangcheng , Qian Yinfeng , Chen Xianwen , Yu Yongqiang 
Published: October 2021

Background: The thalamus is not only a key relay node of the thalamocortical circuit but also a hub in the regulation of gait. Previous studies of resting-state functional magnetic resonance imaging (fMRI) have shown static functional connectivity (FC) between the thalamus and the cortex are disrupted in Parkinson's disease (PD) patients with freezing of gait (FOG). However, temporal dynamic FC between the thalamus and the cortex has not yet been characterized in these patients.Methods: Fifty PD patients, including 25 PD patients with FOG (PD-FOG) and 25 PD patients without FOG (PD-NFOG), and 25 healthy controls (HC) underwent resting-state fMRI. Seed-voxel-wise static and dynamic FC were calculated between each thalamic nuclei and other voxels across the brain using the 14 thalamic nuclei in both hemispheres as regions of interest. Associations between altered thalamic FC based on significant inter-group differences and severity of FOG symptoms were also examined in PD-FOG.Results: Both PD-FOG and PD-NFOG showed lower static FC between the right lateral posterior thalamic nuclei and right inferior parietal lobule (IPL) compared with HC. Altered FC dynamics between the thalamic nuclei and several cortical areas were identified in PD-FOG, as shown by temporal dynamic FC analyses. Specifically, relative to PD-NFOG or HC, PD-FOG showed greater fluctuations in FC between the left intralaminar (IL) nuclei and right IPL and between the left medial geniculate and left postcentral gyrus. Furthermore, the dynamics of FC between the left pulvinar anterior nuclei and left inferior frontal gyrus were upregulated in both PD-FOG and PD-NFOG. The dynamics of FC between the right ventral lateral nuclei and left paracentral lobule were elevated in PD-NFOG but were maintained in PD-FOG and HC. The quantitative variability of FC between the left IL nuclei and right IPL was positively correlated with the clinical scales scores in PD-FOG.Conclusions: Dynamic FC between the thalamic nuclei and relevant associative cortical areas involved in sensorimotor integration or cognitive function was disrupted in PD-FOG, which was reflected by greater temporal fluctuations. Abnormal dynamic FC between the left IL nuclei of the thalamus and right IPL was related to the severity of FOG.
Dietary Conjugated Linoleic Acid Modulates the Hepatic Circadian Clock Program via PPARα/REV-ERBα-Mediated Chromatin Modification in Mice
Authors: Liu Hao-Yu , Gu Haotian , Li Yanwei , Hu Ping , Yang Yatian , Li Kaiqi , Li Hao , Zhang Kexin , Zhou Bo , Wu Huaxing , Bao Wenbin , Cai Demin 
Published: October 2021

Scope: Disruptions of circadian rhythm cause metabolic disorders and are closely related to dietary factors. In this study, we investigated the interplays between the dietary conjugated linoleic acid (CLA)-induced hepatic steatosis and the circadian clock regulation, in association with lipid homeostasis.Methods and Results: Exposure of mice to 1.5% dietary CLA for 28 days caused insulin resistance, enlarged livers, caused hepatic steatosis, and increased triglyceride levels. Transcriptional profiling showed that hepatic circadian clock genes were significantly downregulated with increased expression of the negative transcription factor, REV-ERBα. We uncovered that the nuclear receptor (NR) PPARα, as a major target of dietary CLA, drives REV-ERBα expression via its binding to key genes of the circadian clock, including Cry1 and Clock, and the recruitment of histone marks and cofactors. The PPARα or REV-ERBα inhibition blocked the physical connection of this NR pair, reduced the cobinding of PPARα and REV-ERBα to the genomic DNA response element, and abolished histone modifications in the CLA-hepatocytes. In addition, we demonstrated that CLA promotes PPARα driving REV-ERBα transcriptional activity by directly binding to the PPAR response element (PPRE) at the Nr1d1 gene.Conclusions: Our results add a layer to the understanding of the peripheral clock feedback loop, which involves the PPARα-REV-ERBα, and provide guidance for nutrients optimization in circadian physiology.
Case Report: Identification of a Novel GNAS Mutation and 1p/22q Co-Deletion in a Patient With Multiple Recurrent Meningiomas Sensitive to Sunitinib
Authors: Hong Weiping , Shan Changguo , Ye Minting , Yang Yanying , Wang Hui , Du Furong , Zhang Xing , Song Chao , Cai Linbo 
Published: October 2021

BackgroundAlthough surgical resection can cure the majority of meningiomas, there are still approximately 20% of patients suffering from an aggressive course with recurrence or progression. In this study, we reported a novel GNAS mutation and 1p/22q co-deletion responding to sunitinib in a patient with multiple recurrent meningiomas.Case PresentationA 53-year-old woman with meningioma was hospitalized due to postoperative tumor progression for 3 weeks. WHO grade I meningioma was pathologically diagnosed after the first three surgeries, but the second recurrence occurred approximately 3 years following the third surgery. Next-generation sequencing was performed on the first two recurrent samples. GNAS mutations and 1p/22q co-deletion were both identified, and amplification at 17q and chromosome 19 was also found in the second recurrent sample, based on which WHO grade II/III meningioma was diagnosed. The lesion in the left cerebellopontine angle area enlarged after use of radiotherapy combined with temozolomide chemotherapy for 2 months. When sunitinib was added, the residual lesions began to lessen and continuously reduced.ConclusionThis typical case suggested that timely molecular diagnosis for refractory meningiomas contributed to guiding the molecular classification and clinicians to make more reasonable individualized therapeutic regimens, consequently benefiting the patients. This case report also highlighted the potential role of sunitinib in the treatment of refractory meningiomas.
Effect of Sirolimus on the Level of Peripheral Blood Lymphocyte Autophagy in Children With Systemic Lupus Erythematosus
Authors: Wang Xinliang , Su Qingxiao , Dou Zhiyan , Zhao Xue , Zhang Naiqi , Yu Bo , Wang Yuxue , Rong Zanhua 
Published: October 2021

Background: To observe the changes of autophagy-related protein levels in peripheral blood lymphocytes before and after sirolimus treatment in children with systemic lupus erythematosus (SLE).Methods: Children with SLE were randomly divided into two groups, 28 in the traditional treatment group and 28 in the sirolimus group. Fifteen healthy children who were in the same period were collected as the normal control group. Clinical laboratory indexes, the percentage of routine lymphocytes, complement C3, complement C4, serum Anti-dsDNA and SLEDAI were detected.Results: At 3 and 6 months after treatment, compared with the traditional treatment group, the percentage of routine lymphocytes in the sirolimus group increased (P = 0.03), SLEDAI score and positive rate of Anti-dsDNA decreased (P = 0.01). Compared with normal children, the expression of microtubule-associated protein 1 light chain 3 (LC3) protein in peripheral blood lymphocytes was significantly higher (P = 0.006); peripheral blood expression of P62/SQSTM1 (sequestosome 1) protein in lymphocytes decreased (P = 0.02).Conclusion: Sirolimus can play a role in the treatment of systemic lupus erythematosus by regulating the level of autophagy.
Changes in Incidence of Notifiable Infectious Diseases in China Under the Prevention and Control Measures of COVID-19
Authors: Chen Bizhen , Wang Meiling , Huang Xun , Xie Maokun , Pan Liting , Liu Huiwen , Liu Zhenguo , Zhou Pengcheng 
Published: October 2021

Aim: The aim of this study was to analyze the changes in incidence of notifiable infectious diseases in China under the prevention and control measures of COVID-19.Methods: Using descriptive epidemiological methods, data were collected from the official website of the Health Commission of the People's Republic of China, and the prevalence characteristics of notifiable infectious diseases in the country in 2020 were analyzed and compared with the historical data in 2019. Monthly reporting data on influenza and tuberculosis from 2015 to 2019 were also collected.Results: Except for COVID-19, the total number of notifiable infectious diseases cases in 2020 was 6,366,176, a decrease of 41.38% year-on-year compared with 2019. Category B and C notifiable infectious diseases decreased by 14.84 and 54.98% year-on-year, respectively (P &lt; 0.01). The top three incidence rates were influenza (87.63 cases/100,000), hepatitis B (81.36 cases/100,000) and other infectious diarrhea (76.33 cases/100,000). Three types of diseases with the largest decline were influenza (−2,280,502 cases), hand-foot-mouth disease (−1,174,588 cases), and other infectious diarrhea diseases (−275,746 cases). Compared with 2019, respiratory infectious diseases were reported to be in the largest decline in 2020, followed by intestinal infectious diseases, blood-borne and sexually transmitted diseases, natural foci, and insect-borne infectious diseases. The monthly reported incidences of influenza and tuberculosis in 2020 were lower than the average of the previous 5 years.Conclusion: In 2020, the incidence of most notifiable infectious diseases in China showed a downward trend, non-pharmaceutical interventions (NPIs)such as the wearing of masks, frequent hand-washing, more ventilation, less gathering, etc, played an positive role in the prevention and control of respiratory and intestinal infectious diseases. The various public health intervention strategies and measures adopted by China to contain COVID-19 can provide a reference for the prevention and control of infectious diseases in other countries.
Abdominal Cocoon With Intestinal Perforation: A Case Report
Authors: Hu Qiang , Shi Jianfeng , Sun Yuanshui 
Published: October 2021

Introduction: Abdominal cocoon is a very rare abdominal disease. Abdominal cocoon mainly leads to intestinal obstruction, and abdominal cocoon with gastrointestinal perforation is rare.Case Presentation: We report a 63-year-old man who was admitted to our hospital with “persistent lower abdominal pain for one day”. Abdominal CT examination revealed a small amount of free gas in the abdominal cavity, ascites, and gastrointestinal perforation. An emergency operation was performed. During the operation, the end of the right lower abdominal ileum was found to be conglutinated and twisted into a mass, a local intestinal dilatation, and obstruction, local intestinal wall was black and gangrene, and fecal effusion flowed out. The adhesions were carefully separated, and the necrotic small intestine was removed. The operation process went smoothly, and the patient recovered well after the operation.Conclusion: The cases of intestinal perforation caused by the abdominal cocoon are very rare. In clinical work, when we encounter patients with gastrointestinal perforation, we need to carefully ask the history. When the patients had no digestive system diseases in the past, we need to consider the possibility of the abdominal cocoon with perforation.
Application of Whole Genome Sequencing to Understand Diversity and Presence of Genes Associated with Sanitizer Tolerance in Listeria monocytogenes from Produce Handling Sources
Authors: Bland Rebecca N. , Johnson Jared D. , Waite-Cusic Joy G. , Weisberg Alexandra J. , Riutta Elizabeth R. , Chang Jeff H. , Kovacevic Jovana 
Published: October 2021

Recent listeriosis outbreaks linked to fresh produce suggest the need to better understand and mitigate L. monocytogenes contamination in packing and processing environments. Using whole genome sequencing (WGS) and phenotype screening assays for sanitizer tolerance, we characterized 48 L. monocytogenes isolates previously recovered from environmental samples in five produce handling facilities. Within the studied population there were 10 sequence types (STs) and 16 cgMLST types (CTs). Pairwise single nucleotide polymorphisms (SNPs) ranged from 0 to 3047 SNPs within a CT, revealing closely and distantly related isolates indicative of both sporadic and continuous contamination events within the facility. Within Facility 1, we identified a closely related cluster (0–2 SNPs) of isolates belonging to clonal complex 37 (CC37; CT9492), with isolates recovered during sampling events 1-year apart and in various locations inside and outside the facility. The accessory genome of these CC37 isolates varied from 94 to 210 genes. Notable genetic elements and mutations amongst the isolates included the bcrABC cassette (2/48), associated with QAC tolerance; mutations in the actA gene on the Listeria pathogenicity island (LIPI) 1 (20/48); presence of LIPI-3 (21/48) and LIPI-4 (23/48). This work highlights the potential use of WGS in tracing the pathogen within a facility and understanding properties of L. monocytogenes in produce settings.