bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three Dimensional Measuring Points Locating Algorithm Based Texture-Patched Matrix Completion Algorithm for Indoor 3D REM Design
Authors: MAITI PRADIPTA , Mitra Debjani 
Published: September 2021

Abstract
In this paper, a novel texture-patch transformed (TPT) three dimensional (3D) matrix completion (MC) method has been proposed with the support of novel 3D measuring points (MPs) locating algorithm to generate practical received signal strength (RSS) database assisted indoor 3D radio environment map (REM) of ultra-high frequency (UHF) television (TV)-band. The exploration of TV-band results in TV white and grey space (TV-WS and TV-GS), which are competent resolution to recoup excess data traffic through cognitive radio networks (CRNs) by dynamic spectrum access (DSA) by secondary user (SU). Maximum wireless data traffic generates in indoor and altitude considered exploration of REM achieves high data rate, so selecting interpolation algorithm is important for getting accurate and timely generated REM. Many MC algorithm shows better results than standard interpolation methods. Instead of using layer-by-layer MC algorithm, TPT-MC algorithm could be used through 3D↔2D conversion. Patch size has been considered through symmetric dataset profile. MC criteria based analysis shows TPT-MC algorithm takes lesser no. of MPs than layer-by-layer MC algorithm. Singular value thresholding (SVT) algorithm is used MC algorithm. TPT-SVT shows advantage over layer-by-layer SVT algorithm on RMSE, correlation, best-fit-line and simulation time on same no. of dataset. The result analysis shows that TPT-SVT algorithm is better in RMSE, closest best-fit-line and correlation coefficient than 2D IDW2, 2D K-NN, 2D kriging, TPT-IDW2, TPT-K-NN, TPT-kriging, 3D IDW2 and layer-by-layer SVT algorithm. Computation time of TPT-SVT is better than 3D IDW2 and SVT. TPT-SVT algorithm takes lesser no. of dataset than SVT algorithm for faithful MC.
Combined Effects of the Pesticide Spinetoram and the Cyanobacterium Microcystis on the Water Flea Daphnia Pulex
Authors: Shen Qiutong , Zhan Yihe , Jia Xuanhe , Li Bangping , Zhu Xuexia , Gao Tianheng 
Published: September 2021

Abstract
Spinetoram is one of the most worldwidely used pesticides for its high insecticidal efficacy and low human toxicity Following the large usage of spinetoram, the ecotoxicity and environmental risks to aquatic ecosystems have call for urgent study In the present study, we investigated the combined effects of spinetoram and the harmful alga Microcystis aeruginosa in freshwater, on survival and reproduction of Daphnia pulex Acute toxicity test of spinetoram resulted in negative effects on survival, with a 48h-LC50 value of 3771 µg L–1 Under the long-time exposure to environmentally relevant concentrations (018 and 035 µg L–1) of spinetoram and a low composition of Microcystis (30%) in the diet, D pulex showed both shorter longevity and lower fecundity, the time to first brood was also increased At population level, carrying capacity was highly decreased by spinetoram and Microcystis, whereas a significant decrease of intrinsic growth rate was observed at 035 µg L–1 spinetoram with 30% Microcystis as food The present study highlighted that pesticide spinetoram had highly toxic effects on D pulex and could reduce the tolerance of D pulex to M aeruginosa, causing great effects on D pulex population in natural waterbodies
The Polygenic Risk Score Knowledge Base: A Centralized Online Repository for Calculating and Contextualizing Polygenic Risk Scores
Authors: Page Madeline , Vance Elizabeth , Cloward Matthew , Ringger Ed , Dayton Louisa , Initiative ADNI Alzheimer’s Disease Neuroimaging , Miller Justin , Kauwe John 
Published: September 2021

Abstract
Introduction: Genome-wide association (GWA) studies identify correlation between genetic variants and phenotypes. GWA findings can be used to calculate polygenic risk scores, which represent the aggregate genetic risk across all associated loci. Methods: We developed a centralized polygenic risk score calculator containing over 2,300 GWA studies from the NHGRI-EBI GWAS Catalog. Polygenic risk scores are calculated from user-uploaded data using various user-defined parameters across any disease(s) or studies. Results: The Polygenic Risk Score Knowledge Base (https://prs.byu.edu) and command-line interface facilitate user-specific polygenic risk score calculations. We report study-specific polygenic risk scores across the U.K. Biobank, 1000 Genomes, and the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and identify potentially confounding genetic risk factors in ADNI.Discussion: We introduce the first streamlined analysis tool and web interface to calculate and contextualize polygenic risk scores across various studies. We anticipate that the PRSKB will facilitate a wider adaptation and innovative use of polygenic risk scores in disease research. Data Availability: This project is documented online at https://polyriskscore.readthedocs.io/en/latest/, and all programs are publicly available at https://github.com/kauwelab/PolyRiskScore. A web interface is also available at https://prs.byu.edu/.
Investigation on Potential Correlation Between the RNA-Binding Protein of Evolutionarily Conserved MEX3 Family and Non–Small-Cell Lung Cancer
Authors: Zhang Ming , Zhang Hualiang , Cao Linfeng , Hou Gouxin , Lu Chao , Fang Zhixian , Lv Xiaodong , Deng Jingjing 
Published: September 2021

Abstract
Background

As mRNA binding proteins, MEX3 (muscle excess 3) family highlights its unique characteristics and plays an emerging role in post-transcriptionally regulating programmed of biological processes, including tumor cell death and immunological relevance. These have been shown to be involved in various diseases, however, the role of MEX3 in non-small-cell lung cancer (NSCLC) has not been fully elucidated.
Results

In this study, we found that the sequence or copy number of MEX3 gene did not change significantly, which can explain the stability of malignant tumor development through the COSMIC database. Further, gene expression in NSCLC was examined using the Oncomine™ database, and the prognostic value of each gene was analyzed by Kaplan-Meier analysis. The results showed that overexpressed of MEX3A, MEX3B, MEX3C and MEX3D were associated with significantly lower OS in patients with NSCLC and LUAD, while overexpressed of MEX3D was associated with significantly poorer OS in patients with LUSC. We also applied the Tumor Immune Estimation Resource (TIMER) tool to assess the correlations between distinct MEX3 and the infiltrating immune cell landscape.
Conclusion

On this subject, we have learned about the complexity and heterogeneity of NSCLC through MEX3. We found that most of MEX3 is highly expressed in NSCLC. High expression indicates a poor prognosis and has a certain immune correlation. Therefore, these conclusions can lay a framework for the prognosis of NSCLC patients and the development of treatment strategies in the future.
High-Intensity Focused Ultrasound or Uterine Artery Embolization Combined With Ultrasound-Guided Dilatation and Curettage in Cesarean Scar Pregnancy: A Retrospective Cohort Study
Authors: Gan Yanqiong , Zhou Yuqin , Wang Yanlin , Jing Qiao , Zhang Feng , Shi QI 
Published: September 2021

Abstract
BackgroundCesarean scar pregnancy (CSP) is a rare and new form of ectopic pregnancy. With increasing rate of cesarean delivery worldwide during the decades, the incidence of CSP increases as well. It may cause massive hemorrhage, uterine rupture, placenta percreta, hysterectomy or even maternal death. This study is to compare the efficacy of high-intensity focused ultrasound (HIFU) and uterine artery embolization (UAE) associated with ultrasound-guided dilatation and curettage (UGDC) in three types of CSP. Methods403 CSP patients were treated with UGDC after pretreatment. Among them, 288 patients chose HIFU before UGDC, while the others (n=115) chose UAE. The body mass index (BMI), gravidity, parity, the number of cesarean delivery, the interval of previous cesarean delivery (PCD), the length, thickness and width of uterus and gestational sac, fetal cardiac activity, the types of CSP, the baseline of beta-human chorionic gonadotropin (β-HCG), the value of β-HCG before and 24 hours after pretreatment, hospital expenditure, the value of hemoglobin before and 24 hours after dilatation and curettage (D&C) and severe complications were collected and compared between the two groups. ResultsAll patients were successfully treated without severe complications. There was no significant difference in maternal age, BMI, gravidity, parity, the number of cesarean delivery, the interval of PCD, the volume of uterus and gestational sac, fetal heart activity, types of CSP and baseline serum β-HCG level between the two groups. The median hospital expenditure and blood loss were less in HIFU group and the median decline rate of β-HCG was higher in HIFU group (p=0.000, p=0.000, p=0.006, respectively). 39 (13.54%) patients in HIFU group, while 21 (18.26%) cases in UAE group used Foley balloon to control the vaginal bleeding.ConclusionBoth HIFU and UAE combined with UGDC have high successful rate in the treatment of CSP. While, HIFU followed by UGDC might be better for less hospital expenditure, blood loss and higher decline rate of β-HCG.
Pre-Clerkship EPA Assessments: A Thematic Analysis of Rater Cognition
Authors: Meyer Eric G. , Harvey Emily , Durning Steven J. , Uijtdehaage Sebastian 
Published: September 2021

Abstract
Background. Entrustable Professional Activities (EPAs) assessments measure learners’ competence with an entrustment or supervisory scale. Designed for workplace-based assessment EPA assessments have also been proposed for undergraduate medical education (UME), where assessments frequently occur outside the workplace and may be less intuitive, raising validity concerns. This study explored how assessors make entrustment determinations in UME, to include the impact of longitudinal student-assessor relationships.Methods. A qualitative approach using think-alouds was employed. Assessors assessed two students (familiar and unfamiliar) completing a history and physical exam using a supervisory scale and then thought-aloud after each assessment. We conducted a thematic analysis of assessors’ response processes and compared them based on their familiarity with a student.Results. Four themes and fifteen subthemes were identified. The most prevalent theme related to “student performance.” The other three themes included “frame of reference,” “assessor uncertainty,” and “the patient.” “Previous student performance” and “affective reactions” were subthemes more likely to inform scoring when faculty were familiar with a student, while unfamiliar faculty were more likely to reference “self” and “lack confidence in their ability to assess.”Conclusions. Student performance appears to be assessors’ main consideration for all students, providing some validity evidence for the response process in EPA assessments. Several problematic themes could be addressed with faculty development while others appear to be inherent to entrustment and may be more challenging to mitigate. Differences based on assessor familiarity with student merits further research on how trust develops over time.
Self-Reported Mental Health During the COVID-19 Pandemic and its Association with Alcohol and Cannabis Use: A Latent Class Analysis
Authors: Somé Nibene Habib , Wells Samantha , Felsky Daniel , Hamilton Hayley A. , Ali Shehzad , Elton-Marshall Tara , Rehm Jürgen 
Published: September 2021

Abstract
Background: Mental health problems and substance use co-morbidities during the COVID-19 pandemic are a public health priority. Identifying individuals at high-risk of developing these problems can directly inform mitigating strategies. We aimed to identify distinct groups of individuals (i.e., latent classes) based on patterns of self-reported mental health symptoms and investigate associations with alcohol and cannabis use.Methods: We used data from six successive waves of a web-based cross-sectional survey of adults aged 18 years and older living in Canada (6,021 participants). We applied latent class analysis to three domains of self-reported mental health: anxiety, depression, and loneliness. Logistic regression was used to characterize latent class membership, estimate the association of class membership with alcohol and cannabis use, and perform sex-based analyses.Results: We identified two distinct classes: 1) individuals with low scores on all three mental health indicators (no/low-symptoms) and 2) those reporting high scores (high-symptoms). Those at greater risk of being in the high-symptoms class were likely to be women (adjusted odds ratio (aOR) =1.34, 95%CI:1.18-1.52), people worried about getting COVID-19 (aOR=2.39, 95%CI:2.02-2.82), and those with post-secondary education (aOR=1.26, 95%CI:1.02-1.55). Asian ethnicity (aOR=0.78, 95%CI:0.62-0.97), married status (aOR=0.71, 95%CI:0.59-0.85), seniors (aOR=0.38, 95%CI:0.32-0.47), individuals in households with income higher than CAD$40,000: $40,000-$79,000 (aOR=0.73, 95%CI:0.60-0.90), $80,000-$119,000 (aOR=0.60, 95%CI:0.48-0.74) and $120,000+ (aOR=0.47, 95%CI:0.37-0.59) were at lower odds of being in the high-symptoms class. Individuals in the high-symptoms class were more likely to use cannabis at least once a week (aOR=2.25, 95%CI:1.90-2.67), drink alcohol heavily (aOR=1.69, 95%CI:1.47-1.95); and increase the use of cannabis (aOR=3.48, 95%CI:2.79-4.35) and alcohol (aOR=2.37, 95%CI:2.05-2.73) during the pandemic. Women in the high-symptoms class had higher odds of increasing alcohol use than men.Conclusions: We identified the determinants of experiencing high-symptoms of anxiety, depression, and loneliness, and found a significant association with alcohol and cannabis consumption. This suggests that initiatives and supports are needed to address mental health and substance use multi-morbidities, particularly regarding alcohol use in women.
Polycyclic Aromatic Hydrocarbons (PAHs) In The Upstream Rivers of Taihu Lake Basin, China: Spatial Distribution, Sources And Environmental Risk
Authors: Wang Lingling , Ren Xiaoming , Wang Xiaoping , Ye Perran , Wang Fei , Cheng Jiade , Chen Yan , Yu Ang , Zhang Limin , Qiu Yang 
Published: September 2021

Abstract
The polycyclic aromatic hydrocarbons (PAHs) pollution in Taihu Lake Basin has caused widespread concern. However, the spatial temporal distribution of PAHs in the upstream rivers of Taihu Lake Basin remains largely unknown. Thus, this study aims to investigate the level, spatial distribution, sources and environment risk caused by PAHs in upstream rivers of Taihu Lake Basin. The concentrations of total 16 PAHs (∑16PAHs) ranged from 188.64 to 1060.39 ng/g, with an average of 472.62 ng/g. Compared with low-molecular-weight (LMW) PAHs, high-molecular-weight (HMW) PAHs were more resistant to degradation and easier to accumulate in the sediment. The results of source analysis demonstrated that the PAH pollution was mainly sourced from mixture of fuel combustion and direct petroleum spillage. The ecological risk assessment showed that moderate ecological risk caused by the PAH contaminants might occur in most sample sites. The incremental lifetime cancer risk (ILCRs) ranged from 2.07 ×10-4 - 2.66 × 10-3 for children and 9.66 ×10-5 - 1.24 × 10-3 for adult, indicating moderate cancer risk of PAH-contaminated sediments.
Spectrum of Heart Diseases at a Referral Tertiary Care Hospital in Somalia, Mogadishu: An Echocardiographic Study
Authors: Alıcı Gökhan , Genç Ömer 
Published: September 2021

Abstract
Background: To investigate the frequencies and patterns of cardiovascular diseases (CVD), including rheumatic and congenital heart diseases, assessed by echocardiographic examinations in the only referral tertiary care hospital in Mogadishu, the capital of Somalia.Methods: This retrospective, descriptive registry reviewed the pathological echocardiographic findings of 1140 patients aged 0-100 years who were admitted to the cardiology outpatient clinic in a tertiary training hospital in Mogadishu.Results: Hypertensive heart disease (HHD) 454 (39.8%) and degenerative valvular disease 395 (34.6%) were the most common comorbidities. Congenital heart diseases (CHD) were detected in 151 (13.2%) of the patients, with the most common ones including atrial septal defect (ASD) 37 (3.2%) and ventricular septal defect (VSD) 26 (2.3%).Rheumatic heart disease (RHD) was detected in 84 (7.4%) patients, among whom the most common age range was 16-30 years (40.5%), followed by 31-45 years (31%) and 0-15 years (15.5%). Conclusıon: In the present study, we found that HHD was the most common comorbidity , followed by degenerative valvular disease, Heart failure with reduced ejection fraction(HFrEF),and Ischemic heart disease(IHD).Moreover, the most common valvular disease was mitral insufficiency and the most common CHD was ASD.
Tinospora Cordifolia Leaves Derived Carbon Dots For Cancer Cell Bioimaging, Free Radical Scavenging, And Fe3+ Sensing Applications
Authors: Mohapatra Debadatta , Pratap Ravi , Pandey Vivek , Dubey Pawan K. , Agrawal Ashish K. , Parmar Avanish S. , Sahu Alakh Niranjan 
Published: September 2021

Abstract
Herein, we report the fabrication of Tinospora cordifolia leaves-derived carbon dots (TCLCDs) from aqueous extract of leaves as carbon source via simple, environmental friendly, hydrothermal carbonization (HTC) technique. The synthesized TCLCDs were characterized for their physicochemical properties and further explored for in-vitro cancer cell bioimaging, radical scavenging, and metal ion sensing. The synthesized TCLCDs showed excitation-dependent emission property with maximum emission at 435 nm under the excitation of 350 nm. The High-Resolution Transmission Electron Microscopy (HRTEM) results revealed a roughly spherical shape with an average diameter of 5.47 nm. The diffused ring pattern of Selected Area Electron Diffraction (SAED) and halo diffraction pattern of X-ray diffraction (XRD) disclosed their amorphous nature. The Energy Dispersive X-ray (EDX) showed the existence of C, N, and O. The Fourier-transform infrared spectroscopy (FTIR) revealed the presence of -OH, -NH, -CN, and -CH groups. The TCLCDs showed excellent cellular biocompatibility with dose-dependent bioimaging results in melanoma (B16F10) and cervical cancer (SiHa) cell lines. Also, they exhibited excellent scavenging of free radicals with an IC50 value of 0.524 mg/mL & selective Fe3+ ion sensing with a detection limit of 0.414 µM. Further, they exerted excellent bacterial biocompatibility, photostability, and thermal stability. The overall results reflected their potential for in-vitro cancer cell bioimaging, free radical scavenging, and selective Fe3+ ion sensing.
Enhanced Performance of Natural Polymer Coagulants For Dye Removal From Wastewater: Coagulation Kinetics, And Mathematical Modelling Approach
Authors: Obiora-Okafo Ifeoma Amaoge , Onukwuli Okechukwu Dominic , Igwegbe Chinenye Adaobi , Onu Chijioke Elijah , Omotioma Monday 
Published: September 2021

Abstract
This study explores the potentials of Brachystegia eurycoma coagulant (BEC) and Vigna subterranean coagulant (VSC) as natural organic polymers (NOPs) for the decolourisation of Crystal Ponceau 6R (AR 44) in wastewater. Materials characterisation studies were done on the precursors. Detailed kinetics study was employed. The decolourisation procedures were evalu­ated through time-dependent reduction in the concentration of particles, with the variation of the independent parameters. The proximate analysis showed protein contents of 19.77% and 18.15% for BEC and VSC, respectively. The functional test shows the presence of –OH, N–H, and C=H. Surface morphological study reveals that some rough surfaces, different pores sizes, and compact-net structures were evidenced. The order of removal efficiency was VSC > BEC with an optimum of 88.8% and 73.3%, respectively. The values of K and α obtained for BEC and VSC were 6.38 x 10-4 Lmg-1min-1, 1.8 and 4.03 x 10-3 L/mg-1min-1, 1.9, respectively. The coagulation time, Tag of 31.35 and 26.96 min for BEC and VSC respectively disclosed a quick coagulation. The coagulation-flocculation kinetics demonstrated that the process conforms to the pseudo-second-order model with R2 >0.997, suggesting that the rate-controlling mechanism is governed by chemisorption. The experimental data were well predicted by the cross-validation test, with percentage mean relative deviation modulus (M%) of 3.26 and 2.54 for BEC and VSC, respectively. These coagulants have added meaningful progress in wastewater treatment by coagulation-flocculation while displaying significant adsorption features. Likewise, the usage of kinetics studies and particle behaviour modelling should be a prerequisite in water treatment processes.
A New Fluoride Chemodosimeter Based On 3-Ether-Substituted 1, 8-Naphthalimide Derivatives
Authors: Chen Xi , Shao Haibing , Zhu Tingting , Chen Zhihua , Hu Yan , Zhang Hua , Liu Chuanxiang 
Published: September 2021

Abstract
We developed a new chromogenic and fluorescent "off–on" 1,8-naphthalimide-derivated chemosensor 1 based on an F−-triggered desilylation reaction. It showed significant variations in UV/Visible absorption (510 nm) and fluorescence emission wavelength (570 nm) for selective detection of fluorides in tetrahydrofuran. Moreover, chemodosimeter 1-loaded test strips were successfully fabricated todetect fluorides efficiently.
Assessment of The Effect of Interprofessional Professionalism Training On The Surgical Team Members' Perception of The Ethical Climate
Authors: Keshmiri Fatemeh , Hoseinpour Azam 
Published: September 2021

Abstract
BackgroundThe aim of present study was to assess the effect of interprofessional education concerning interprofessional professionalism on learners' perception of the ethical climate of the operating room.MethodThe present study is quasi-experimental design. Learners include surgical residents, operating room technicians, and anesthesia technicians (n=130) that distributed to intervention and control groups. The objectives of the intervention were the development of competencies of ethics and professionalism (including communication, altruism, respect, and excellence). The educational strategy was interprofessional education and the main method of training was scenario-based learning. Participants completed the Olson Moral Climate Questionnaire before and one month after the intervention. We used descriptive tests (mean, SD, percentage), student t-test and ANOVA to compare the scores of learners in the intervention and control groups.ResultsThe results of the study showed that the scores of the learners in the intervention group 4.05 (0.31) improved significantly compared to the control group 3.35 (0.37) (P = 0.0001). The scores of learners in the domain of ​​“managers” improved higher and the domain of ​​physicians improved lesser than other domains. There was no significant difference between the three groups of residents, operating room, and anesthesia technicians in terms of moral climate scores.ConclusionIn the present study showed the positive effect of interprofessional education interventions on individuals' perceptions of the operating room ethical climate. It is suggest that educational interventions be planned and implemented continuously in the educational systems and hospitals.