bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Emergency Cash Assistance in a Pandemic: Experimental Evidence from Colombia
Authors: Londoño-Vélez Juliana , Querubín Pablo 
Published: April 2021

AbstractWe study the impact of money on households during the COVID-19 pandemic. In March 2020, Colombia rolled out a new unconditional cash transfer (UCT) to 1 million households in poverty worth US$19 (PPP US$55.6) and paid every five to eight weeks. Using a randomized control trial and linked administrative and survey data, we find the UCT had positive (albeit modest) effects on measures of household well-being (e.g., financial health, food access). Moreover, the UCT boosted support for emergency assistance to households and firms during the crisis and promoted social cooperation. Finally, we explore the bottlenecks in expanding mobile money during a pandemic.
Negative Philosophy: Time, Death and Nothingness
Authors: Dastur Françoise 
Published: April 2021

Abstract
Retracing the way I have followed since the beginning of my philosophical studies, I focus on the main issues that have guided my teaching and research: Time, Death, and Nothingness, all of which take place in the domain of what I have called “negative philosophy”. My first interest was in the problem of language and logic in their relation to temporality, a special privilege being granted in this respect to poetry; subsequently I concentrated my work on the thematic of death and finitude, in order to show that mourning and relation to absence are what establish a fundamental difference between the human being and the animal; and finally, the critique of Western ontology has brought me to concentrate my research on Eastern thinking, with a special engagement with the thematic of nothingness in Indian and Japanese Buddhism. All my work in philosophy has been guided by Heidegger’s question of the relation between Being and Time.
First study of the Polycladida (Rhabditophora, Platyhelminthes) from the Pacific Coast of Costa Rica
Authors: SOUTULLO PATRICIA , CUADRADO DANIEL , NOREÑA CAROLINA 
Published: April 2021

In the present work was carried out in the intertidal zone of Las Baulas de Guanacaste National Marine Park (PNMB) located on the Pacific coast of Costa Rica. The main objective was to contribute to knowledge about the invertebrate diversity of the park, one of the richest bioregions on the planet, about which little is known. This study assesses the Order Polycladida Lang, 1884, a cornerstone of this ecosystem and one of the most cosmopolitan and plastic invertebrate taxa in the animal kingdom. In total, 57 individuals were collected in the rocky intertidal zone of Carbón and Langosta beaches. Nine different species were identified, of which four are new for Costa Rica: Semonia bauliensis n. sp.; Cryptostylochus sesei n. sp.; Paraplanocera angeli n. sp., Prostheceraeus fitae n. sp.; and five new records: Paraplanocera oligoglena (Schmarda, 1859); Marcusia ernesti Hyman, 1953; Enchiridium magec Cuadrado, Moro & Noreña, 2017; Pseudobiceros bajae (Hyman, 1953); and the genus Boninia spp.
Submesoscale Eddies in the Upper Ocean of the Kuroshio Extension from High-resolution Simulation: Energy Budget
Authors: Cao Haijin , Fox-Kemper Baylor , Jing Zhiyou 
Published: April 2021

AbstractThe submesoscale energy budget is complex and remains understood only in region-by-region analyses. Based on a series of nested numerical simulations, this study investigated the submesoscale energy budget and flux in the upper ocean of the Kuroshio Extension, including some innovations for examining submesoscale energy budgets in general. The highest-resolution simulation on a ~500 m grid resolves a variety of submesoscale instabilities allowing an energetic analysis in the submesoscale range. The frequency–wavenumber spectra of vertical vorticity variance (i.e., enstrophy) and horizontal divergence variance were used to identify the scales of submesoscale flows as distinct from those of inertia-gravity waves but dominating horizontal divergence variance. Next, the energy transfers between the background scales and the submesoscale were examined. The submesoscale kinetic and potential energy (SMKE and SMPE) were mainly contained in the mixed layer and energized through both barotropic (shear production) and baroclinic (buoyancy production) routes. Averaged over the upper 50 m of ROMS2, the baroclinic transfers amounted to approximately 75% of the sources for the SMKE (3.42 × 10−9 W/kg) versus the remaining 25% (1.12 × 10−9 W/kg) via barotropic downscale KE transfers. The KE field was greatly strengthened by energy sources through the boundary—this flux is larger than the mesoscale-to-submesoscale transfers in this region. Spectral energy production, importantly, reveals upscale KE transfers at larger submesoscales and downscale KE transfers at smaller submesoscales (i.e., a transition from inverse to forward KE cascade). This study seeks to extend our understanding of the energy cycle to the submesoscale and highlight the forward KE cascade induced by upper-ocean submesoscale activities in the research domain.
Absolute lymphocyte count proliferation kinetics after CAR T-cell infusion impact response and relapse
Authors: Faude Sophia , Wei Jane , Muralidharan Kavitha , Xu Xiaoming , Wertheim Gerald , Paessler Michele , Bhoj Vijay G. , Grupp Stephan A. , Maude Shannon L. , Rheingold Susan R. , Pillai Vinodh 
Published: April 2021

AbstractCD19-directed chimeric antigen receptor (CAR) T cells show characteristic proliferation kinetics after infusion that correlate with response. Clearance of circulating disease, B-cell aplasia (BCA), and cytokine release syndrome (CRS) are used to observe CAR T-cell function, given the lack of commercial CAR T-cell measurement assays. We investigated the utility of common hematology laboratory parameters in 166 patients with B-cell acute lymphoblastic leukemia (B-ALL) who were treated with CAR T-cell therapy targeting CD19. CAR T-cell infusion was followed by disappearance of circulating blasts in 86% of patients at a median of 6 days. After a lag phase, there was a rapid expansion in absolute lymphocyte count (ALC) in the second week that coincided with the appearance of atypical lymphocytes. The expansion phase was followed by a contraction phase with a concomitant decrease in atypical lymphocytes. In vitro CAR T-cell studies showed similar kinetics and morphological changes. Peak ALC and overall expansion was greater in sustained responders compared with that in nonresponders. Patients with early loss of BCA and those with eventual CD19+ minimal residual disease/relapse showed lower overall lymphocyte expansion compared with the controls. Pleomorphic lymphocytosis was noted in the cerebrospinal fluid at post-CAR time points. We conclude that lymphocyte counts and differential can also be used to evaluate CAR T-cell expansion after infusion, along with BCA and CRS. This is the first report to characterize the morphology of CAR T cells and determine the utility of lymphocyte kinetics.
Differences in physical symptoms between those with and without kidney disease: a comparative study across disease stages in a UK population
Authors: Wilkinson Thomas J. , Nixon Daniel G. D. , Palmer Jared , Lightfoot Courtney J. , Smith Alice C. 
Published: April 2021

Abstract
Background
Those living with kidney disease (KD) report extensive symptom burden. However, research into how symptoms change across stages is limited. The aims of this study were to 1) describe symptom burden across disease trajectory, and 2) to explore whether symptom burden is unique to KD when compared to a non-KD population.

Methods
Participants aged > 18 years with a known diagnosis of KD (including haemodialysis (HD) and peritoneal dialysis (PD)) and with a kidney transplant) completed the Leicester Kidney Symptom Questionnaire (KSQ). A non-KD group was recruited as a comparative group. Multinominal logistic regression modelling was used to test the difference in likelihood of those with KD reporting each symptom.

Results
In total, 2279 participants were included in the final analysis (age 56.0 (17.8) years, 48% male). The main findings can be summarised as: 1) the number of symptoms increases as KD severity progresses; 2) those with early stage KD have a comparable number of symptoms to those without KD; 3) apart from those receiving PD, the most frequently reported symptom across every other group, including the non-KD group, was ‘feeling tired’; and 4) being female independently increased the likelihood of reporting more symptoms.

Conclusions
Our findings have important implications for patients with KD. We have shown that high symptom burden is prevalent across the spectrum of disease, and present novel data on symptoms experienced in those without KD. Symptoms requiring the most immediate attention given their high prevalence may include pain and fatigue.

Trial registration
The study was registered prospectively as ISRCTN11596292.
Surgical choice of non-small cell lung cancer with unexpected pleural dissemination intraoperatively
Authors: Hu Junjie , Chen Yan , Zhu Xinsheng , Ma Qiang , Zhang Jing , Jiang Gening , Zhang Peng 
Published: April 2021

Abstract
Background
Whether patients with non-small cell lung cancer (NSCLC) with unexpected pleural dissemination (UPD) could get survival benefit from tumor resection remained controversial.

Methods
Totally, 169 patients with NSCLC with UPD were included between 2012 and 2016. Patients were divided into the tumor resection and open-close group. Progression-free survival (PFS) and overall survival (OS) were compared with a log-rank test. The multivariable Cox analysis was applied to identify prognostic factors.

Results
Sixty-five patients received open-close surgery and 104 patients underwent main tumor and visible pleural nodule resection. Tumor resection significantly prolonged OS (hazard ratio [HR]: 0.408, P < 0.001), local PFS (HR: 0.283, P < 0.001), regional PFS (HR: 0.506, P = 0.005), and distant metastasis (HR: 0.595, P = 0.032). Multivariable Cox analysis confirmed that surgical method was an independent prognostic factor for OS, local PFS and regional PFS, except distant metastasis. Subgroup analyses indicated that tumor resection could not improve OS in the patients who received targeted therapy (HR: 0.649, P = 0.382), however, tumor resection was beneficial for the patients who received adjuvant chemotherapy alone (HR: 0.322, P < 0.001). In the tumor resection group, lobectomy (HR: 0.960, P = 0.917) and systematic lymphadenectomy (HR: 1.512, P = 0.259) did not show survival benefit for OS.

Conclusions
Main tumor and visible pleural nodule resection could improve prognosis in patients with UPD who could not receive adjuvant targeted therapy. Sublobar resection without systematic lymphadenectomy may be the optimal procedure.
Profile of central corneal thickness and corneal endothelial cell morpho-density in healthy Congolese eyes
Authors: Kelekele Joseph-Theodore K. , Kayembe David L. , Mwanza Jean-Claude 
Published: April 2021

Abstract
Purpose
To determine the pachymetric and corneal endothelial cell morphometric features and their relationship to ocular and systemic factors in healthy Congolese subjects.

Methods
Non-contact specular microscopy was used in 278 healthy eyes (278 subjects) to measure central corneal thickness (CCT), corneal endothelial cell density (CECD) along with cell size, coefficient of variation (CV) in cell size, and hexagonality (HEX). The lower and upper reference limits and average values for each parameter were determined. Correlation and association of average values with anthropo-demographic and clinical variables were assessed.

Results
The mean age was 38.9 ± 17.2 years (10.9–80.7 years). Average values were 504.2 ± 30.7 μm (CCT), 2907.1 ± 290.9 cells/mm2 (CECD), 348.5 ± 38.4 μm2 (cell size), 32.9 ± 3.6% (CV), and 51.8 ± 7.2% (HEX). CCT was 504.9 ± 33.6 μm in men and 503.6 ± 28.3 μm in women (p = .73); values for CECD were 2917.1 ± 253.5 cells/mm2 and 2899.2 ± 317.8 cells/mm2 (p = 0.61), respectively. Lower and upper reference limits were 449.6 μm and 566.0 μm for CCT, and 2165.3 cells/mm2 and 3414.4 cells/mm2 for CECD, respectively. CCT correlated with body mass index (BMI), (r = − 0.12, P = 0.04). CECD decreased with age (r = − 0.49, P < 0.001), BMI (r = − 0.20, P = 0.001), intraocular pressure (r = − 0.13, P = 0.029) and ocular perfusion pressure (r = − 0.28, P = 0.028). CECD decayed by 8.3 cells/mm2 or 0.30% per year of age and CCT decreased by 0.72 μm per kg/m2.

Conclusions
Mean central cornea was thinner, CECD higher, and references limits lower than reported in other African populations. The CCT and CECD normative values reported herein will be useful for both clinical and research purposes in this population.
Association of working shifts, inside and outside of healthcare, with severe COVID−19: an observational study
Authors: Rowlands A. V. , Gillies C. , Chudasama Y. , Davies M. J. , Islam N. , Kloecker D. E. , Lawson C. , Pareek M. , Razieh C. , Zaccardi F. , Yates T. , Khunti K. 
Published: April 2021

Abstract
Background
Health and key workers have elevated odds of developing severe COVID-19; it is not known, however, if this is exacerbated in those with irregular work patterns. We aimed to investigate the odds of developing severe COVID-19 in health and shift workers.

Methods
We included UK Biobank participants in employment or self-employed at baseline (2006–2010) and with linked COVID-19 data to 31st August 2020. Participants were grouped as neither a health worker nor shift worker (reference category) at baseline, health worker only, shift worker only, or both, and associations with severe COVID-19 investigated in logistic regressions.

Results
Of 235,685 participants (81·5% neither health nor shift worker, 1·4% health worker only, 16·9% shift worker only, and 0·3% both), there were 580 (0·25%) cases of severe COVID-19. The odds of severe COVID-19 was higher in health workers (adjusted odds ratio: 2·32 [95% CI: 1·33, 4·05]; shift workers (2·06 [1·72, 2·47]); and in health workers who worked shifts (7·56 [3·86, 14·79]). Being both a health worker and a shift worker had a possible greater impact on the odds of severe COVID-19 in South Asian and Black and African Caribbean ethnicities compared to White individuals.

Conclusions
Both health and shift work (measured at baseline, 2006–2010) were independently associated with over twice the odds of severe COVID-19 in 2020; the odds were over seven times higher in health workers who work shifts. Vaccinations, therapeutic and preventative options should take into consideration not only health and key worker status but also shift worker status.
The impact of novel and traditional food bank approaches on food insecurity: a longitudinal study in Ottawa, Canada
Authors: Rizvi Anita , Wasfi Rania , Enns Aganeta , Kristjansson Elizabeth 
Published: April 2021

Abstract
Background
Food insecurity is strongly associated with poor mental and physical health, especially with chronic diseases. Food banks have become the primary long-term solution to addressing food insecurity. Traditionally, food banks provide assistance in the form of pre-packed hampers based on the food supplies on hand, such that the food items often do not meet the recipients’ cultural, religious or medical requirements. Recently, new approaches have been implemented by food banks, including choice models of food selection, additional onsite programming, and integrating food banks within Community Resource Centres.

Methods
This study examined changes in food security and physical and mental health, at four time points over 18 months at eleven food banks in Ottawa, Ontario, Canada. The participants – people who accessed these food banks – were surveyed using the Household Food Security Survey Module (HFSSM) and the Short-Form Health Survey Version 2 (SF-12). Statistical analyses included: pairwise paired t-tests between the mean perceived physical and mental health scores across the four waves of data collection, and longitudinal mixed effects regression models to understand how food security changed over time.

Results
The majority of people who were food insecure at baseline remained food insecure at the 18-month follow-up, although there was a small downward trend in the proportion of people in the severely food insecure category. Conversely, there was a small but significant increase in the mean perceived mental health score at the 18-month follow-up compared to baseline. We found significant reductions in food insecurity for people who accessed food banks that offered a Choice model of food distribution and food banks that were integrated within Community Resource Centres.

Conclusions
Food banks offer some relief of food insecurity but they don’t eliminate the problem. In this study, reductions in food insecurity were associated with food banks that offered a Choice model and those that were integrated within a Community Resource Centre. There was a slight improvement in perceived mental health at the 18-month time point; however, moderately and severely food insecure participants still had much lower perceived mental health than the general population.
The validity of the claims-based definition of rheumatoid arthritis evaluated in 64 hospitals in Japan
Authors: Kubota Kiyoshi , Yoshizawa Masaki , Takahashi Satoru , Fujimura Yoshiaki , Nomura Hiroko , Kohsaka Hitoshi 
Published: April 2021

Abstract
Background
An administrative database covering a whole population such as the national database in Japan may be used to estimate the nationwide prevalence of diseases including rheumatoid arthritis (RA) when a well-validated definition of the disease is available. In Japan, the record linkage between the administrative database and medical charts in hospitals is strictly prohibited. A “hospital-based” validation study is one of few possible validation studies where claims kept inside the study hospital are rearranged into the database structure.

Methods
We selected random samples of 19,734 patients from approximately 1.6 million patients who received medical care between February 2018 and January 2019 in one of the 64 hospitals of the Tokushukai Medical Group. We excluded patients whose observation period was less than 365 days and identified 334 patients who met the definition of “possible cases of RA” whose medical charts were then independently evaluated by two rheumatologists. In a sensitivity analysis, we assessed bias due to misclassifying some patients with RA who did not meet the definition of “possible cases of RA” as a patient with no RA.

Results
The kappa coefficient between the two rheumatologists was 0.80. The prevalence of RA in the study population was estimated to be 0.56%. We found that [condition code of RA] and ([any disease-modifying antirheumatic drug] or [oral corticosteroid with no systemic autoimmune diseases (other than RA) and no polymyalgia rheumatica]) had a relatively high sensitivity (approximately 73%) and a high positive predictive value (approximately 80%). In a sensitivity analysis, we found that when some patients with RA who did not meet the definition of “possible cases of RA” were misclassified as a patient with no RA, then this would lead to underestimation of the prevalence of the definition-positive patients and the adjusted prevalence.

Conclusions
We recommend using the claims-based definition of RA (found in the current validation study) to estimate the prevalence of RA in Japan. We also suggest estimating the adjusted prevalence using the quantitative bias analysis method, since the prevalence of the disease in the “hospital-based” validation study is different from that in the administrative database.

Trial registration
The current study is not a clinical trial and hence not subject to trial registration.
Burnout syndrome in Spanish medical students
Authors: Gil-Calderón Javier , Alonso-Molero Jéssica , Dierssen-Sotos Trinidad , Gómez-Acebo Inés , Llorca Javier 
Published: April 2021

Abstract
Background
Burnout syndrome is a frequent syndrome related to people that feel a deterioration in their daily activities due to highly demandant psychological requirements in their workplaces. Within last decades, this syndrome has been studied across medical professionals, concluding that stress levels that physicians suffer is high enough to make them develop burnout syndrome. In the case of medical students, there are some recent studies, although with small samples. For this reason, given that this phenomenon may produce a huge impact in medical students’ development, the aim of this study is to analyze the influential factors that may contribute to its occurrence.

Methods
The necessary information was gathered through a web-based questionnaire, divided in two parts. The first part of the survey included questions related to personal aspects of the students. Burnout related questions (second part) were divided in three subscales to evaluate exhaustion, cynicism, and academic efficacy levels.

Results
Family support for studying medicine is associated with lower burnout levels in all three scales of the Maslach Burnout Inventory. The number of years spent in the degree show the opposite trend: the more years in the degree, the higher score in all burnout scales.

Conclusions
Burnout syndrome is a problem among medical students in Spain that increases with the number of years studying medicine. It should be also noticed that family support and vocational studies are independent factors related to lower levels of burnout.
Effects of coenzyme Q10 on ovarian surface epithelium-derived ovarian stem cells and ovarian function in a 4-vinylcyclohexene diepoxide-induced murine model of ovarian failure
Authors: Lee Hyun Joo , Park Min Jung , Joo Bo Sun , Joo Jong Kil , Kim Yeon Hee , Yang Sun Woo , Kim Chang-Woon , Kim Ki Hyung 
Published: April 2021

AbstractBackgroundSeveral studies have shown that coenzyme Q10 (CoQ10) can rescue ovarian aging and that ovarian surface epithelium (OSE)-derived ovarian stem cells (OSCs) are useful for treating infertility due to ovarian aging. However, few studies have examined the effect of CoQ10 on OSCs. This study was aimed to investigate whether CoQ10 activates OSCs and recovers ovarian function in a 4-vinylcyclohexene diepoxide (VCD)-induced mouse model of ovarian failure.MethodsForty female C57BL/6 mice aged 6 weeks were randomly divided into four groups (n = 10/group): a control group administered saline orally, a CoQ10 group administered 150 mg/kg/day of CoQ10 orally in 1 mL of saline daily for 14 days, a VCD group administered 160 mg/kg/day of VCD i.p. in 2.5 mL of saline/kg for 5 days, and a VCD + CoQ10 group administered VCD i.p. for 5 days injection and CoQ10 (150 mg/kg/day) orally for 14 days. After treatment, follicle counts were evaluated by hematoxylin and eosin (H&E) staining, and ovarian mRNA expressions of Bmp-15, Gdf-9, and c-Kit were examined by quantitative real-time PCR. Serum FSH, AMH, and ROS levels were also measured. Oocyte-like structure counts and the expressions of Oct-4 and MVH were also evaluated after culturing OSE for 3 weeks. In a second experiment, 32 female mice were administered CoQ10 as described above, induced to superovulate using PMSG and hCG, and mated. Numbers of zygotes and embryo development rate were examined.ResultsPostcultured OSE showed significant increases in the numbers of oocyte-like structure and that the expression of Oct-4 and MVH were higher in the VCD + CoQ10 group than in the VCD group (p < 0.05). Numbers of surviving follicles from primordial to antral follicles, numbers of zygotes retrieved and embryo development rate to blastocyst were significantly greater in the VCD + CoQ10 group than in the VCD group (p < 0.01). Serum AMH level and ovarian expressions of Bmp-15, Gdf-9 and c-Kit were also significantly greater in the VCD + CoQ10 group than in the VCD group (p < 0.05). In contrast, serum ROS level was significantly lower in the VCD + CoQ10 group than in the VCD group (p < 0.05).ConclusionThis study shows that CoQ10 stimulates the differentiation of OSE-derived OSCs and confirms that CoQ10 can reduce ROS levels and improve ovarian function and oocyte quality in mice with VCD-induced ovarian failure.