bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping Global Soil Moisture and Evapotranspiration Coupling Strength Based on a Two‐System Method and Multiple Data Sources
Authors: Zhou Jianhong , Yang Kun , Dong Jianzhi , Crow Wade T. , Lu Hui , Zhao Long , Feng Huihui , Tian Jiaxin , Ma Xiaogang , Tian Xin , Jiang Yaozhi 
Published: February 2025

AbstractSoil moisture (SM) is a key state variable in the climate system through its control on evapotranspiration (ET) and ET‐regulated lower atmospheric processes. The SM‐ET coupling strength (SECS) is thus closely linked with land‐atmosphere interactions and its reliability is crucial for Earth system modeling. However, acquiring global maps of unbiased SECS remains challenging given significant levels of error present in globally available SM and ET products. Triple collocation (TC) provides a possible solution; however, it is difficult to apply globally since it requires access to three independent SM‐ET data pairs—a requirement that is difficult to meet in practice. Here, we generate a global SECS map based on a new two‐system approach that requires only two independent SM‐ET data pairs. This two‐system approach is first validated over local ground sites versus a ground‐inclusive benchmark SECS. Subsequently, it is applied to generate a global map of SECS with input from various independent globally available SM‐ET data pairs (identified using the benchmark SECS). Results suggest that previous TC‐based SECS estimates are generally negatively biased due to cross‐correlated error present between RS products. Instead, our generated new SECS map is shown to provide more robust mapping of global SECS—thus offering an important reference for improving Earth system models.
European Arid Anomaly Explained With Southward Drift of Eurasia During the Late Jurassic Polar Shift
Authors: Muttoni Giovanni , Dallanave Edoardo , Della Porta Giovanna 
Published: February 2025

AbstractThe sedimentary successions of several basins in Europe show evidence of widespread Late Jurassic aridification that is considered a long‐standing conundrum in paleoclimate modeling. The distinctive feature of this event is that it appears concentrated in a discrete time interval between the Kimmeridgian (Late Jurassic) and the Berriasian (Early Cretaceous), and that it extended to eastern and southern‐central Asia for a total of ∼10 Mkm2 in roughly the same time interval. Climate modeling has not provided a convincing explanation for this event. We compiled and reviewed paleomagnetic data from several continents including Adria, the African promontory, showing that this large‐scale aridification was produced by an abrupt and transient southward migration of Eurasia toward arid tropical latitudes, while its demise coincided with a “retromotion” to more humid northern latitudes in the Early Cretaceous. This movement is part of a global plate motion event, most likely due to True Polar Wander, that profoundly affected the depositional environments, the ecosystems, and the architecture of sedimentary basins worldwide.
North‐South Asymmetry of Sq Variations at Geomagnetically Conjugate Area
Authors: Liu Xiaocan , Han Peng , Liu Yangkun , Xu Jiyao , Hattori Katsumi , Chen Huaran , Jiao Liguo , Tu Jiyao 
Published: February 2025

AbstractAsymmetry in the northern and southern hemispheres of Sq variations at the middle and low latitudes (within ±50°) is examined by analyzing observations from five pairs of geomagnetically conjugate stations of SuperMAG during quiet days. The results indicate that the asymmetries of the horizontal components of Sq variations (ASYM‐X/Y) significantly vary with season and depend on latitude. First, ASYM‐X of the three pairs of conjugate stations on the polar‐side (44°) of and near (33° and 25°) the Sq focus are stronger from May through October than in the other seasons. ASYM‐X of the two pairs of conjugate stations on the equatorial‐side of focus (14° and 8°) is weak even in the June solstice. The intensity of ASYM‐X on the polar‐side is as strong as that of near focus from May through September and becomes as weak as that of the equatorial‐side in other seasons. Second, the pattern of ASYM‐Y on the polar‐side is different from that at other latitudes, which basically consists of two parts. At other latitudes, ASYM‐Y from April to October has a three‐part pattern. The intensities of ASYM‐Y in 06–10 LT and 14–18 LT decrease with increasing latitude from April to September. Finally, the north‐south hemisphere asymmetry of the Sq variations is mainly caused by the asymmetry of the neutral winds. The seasonal and latitudinal variations of the asymmetry of the migrating tides, especially the zonal component, are essentially consistent with those of the Sq variations.
Nelarabine in T-cell acute lymphoblastic leukemia: intracellular metabolism and molecular mode-of-action
Authors: Hormann Femke M. , Rudd Sean G. 
Published: February 2025

Abstract
T-cell acute lymphoblastic leukemia (T-ALL) patients often have a poor 5-year event-free survival. The only T-ALL specific drug in clinical practice is nelarabine. A prodrug of the deoxyguanosine analog ara-G, nelarabine is a rationally designed agent selective for the treatment of T-cell malignancies. Originally approved for relapsed/refractory T-ALL, it is increasingly used in T-ALL therapy and is currently being evaluated in upfront treatment. Whilst the clinical use of nelarabine has been the topic of multiple review articles, a thorough overview of the preclinical data detailing the molecular underpinnings of its anti-leukemic activity is lacking, which is critical to inform mechanism-based use. Thus, in the present article we conducted a semi-systematic review of the literature and critically evaluated the preclinical knowledge on the molecular pharmacology of nelarabine. Whilst early studies identified ara-G triphosphate to be the principal active metabolite and nuclear DNA synthesis to be a key target, many fundamental questions remain that could inform upon future use of this therapy. These include the nature of nelarabine-induced DNA lesions and their repair, together with additional cellular targets of ara-G metabolites and their role in efficacy and toxicity. A critical avenue of research in need of development is investigation of nelarabine combination therapies, both in the context of current T-ALL chemotherapy regimens and with emerging anti-leukemic agents, and we highlight some areas to pursue. Altogether, we discuss what we can learn from the preclinical literature as a whole and present our view for future research regarding nelarabine treatment in T-ALL.
Breast cancer: pathogenesis and treatments
Authors: Xiong Xin , Zheng Le-Wei , Ding Yu , Chen Yu-Fei , Cai Yu-Wen , Wang Lei-Ping , Huang Liang , Liu Cui-Cui , Shao Zhi-Ming , Yu Ke-Da 
Published: February 2025

Abstract
Breast cancer, characterized by unique epidemiological patterns and significant heterogeneity, remains one of the leading causes of malignancy-related deaths in women. The increasingly nuanced molecular subtypes of breast cancer have enhanced the comprehension and precision treatment of this disease. The mechanisms of tumorigenesis and progression of breast cancer have been central to scientific research, with investigations spanning various perspectives such as tumor stemness, intra-tumoral microbiota, and circadian rhythms. Technological advancements, particularly those integrated with artificial intelligence, have significantly improved the accuracy of breast cancer detection and diagnosis. The emergence of novel therapeutic concepts and drugs represents a paradigm shift towards personalized medicine. Evidence suggests that optimal diagnosis and treatment models tailored to individual patient risk and expected subtypes are crucial, supporting the era of precision oncology for breast cancer. Despite the rapid advancements in oncology and the increasing emphasis on the clinical precision treatment of breast cancer, a comprehensive update and summary of the panoramic knowledge related to this disease are needed. In this review, we provide a thorough overview of the global status of breast cancer, including its epidemiology, risk factors, pathophysiology, and molecular subtyping. Additionally, we elaborate on the latest research into mechanisms contributing to breast cancer progression, emerging treatment strategies, and long-term patient management. This review offers valuable insights into the latest advancements in Breast Cancer Research, thereby facilitating future progress in both basic research and clinical application.
Population-level analyses identify host and environmental variables influencing the vaginal microbiome
Authors: Qin Lang , Sun Tianyong , Li Xiao , Zhao Shigang , Liu Zheng , Zhang Changlong , Jin Congcong , Xu Yanqi , Gao Xuan , Cao Yongzhi , Wang Jiaojiao , Han Ting , Yan Lei , Song Jialun , Zhang Fangfang , Liu Feifei , Zhang Yousheng , Huang Yuzhen , Song Yuping , Liu Yanjun , Zhang Jing , Zhang Xiuqing , Yao Zhina , Chen Honglei , Zhang Zhenzhen , Zhao Shengrui , Feng Yuhan , Zhang Ya-nan , Yu Qian , Cao Fang , Zhao Lijuan , Xie Lei , Geng Ling , Feng Qiang , Zhao Han , Chen Zi-Jiang 
Published: February 2025

Abstract
The vaginal microbiome is critical for the reproductive health of women, yet the differential impacts exerted by the host and by ambient environmental variables on the vaginal microbiome remain largely unknown. Here, we conducted a comprehensive cross-sectional study of the relationships between the vaginal microbiome and 81 matched host and environmental variables across 6755 Chinese women. By 16S rRNA sequencing, we identified four core vaginal microbiota with a prevalence of over 90% and a total median abundance of 98.8%. Twenty-four variables, including physiology, lifestyle behaviors, gynecologic history, social and environmental information, were found associated with the microbiome composition, of which bacterial vaginosis (BV) showed the largest effect size. Age was among the strongest explanatory variables and the vaginal microbiome dynamically succeeded with increasing age, especially with a composition turning point at the age of 45. Our mediation analyses indicated that the effects of age on the microbiome could be mediated by variables such as parity number and lifestyles. We further classified the vaginal microbiomes of the population into 13 “Vagitypes”. Women with Lactobacillus iners- and Lactobacillus jensenii-dominated Vagitypes had significantly higher live birth rate than those with Vagitype dominated by Fannyhessea vaginae (53.40%, 59.09% vs 21.43%; OR [95% CI]: 3.62 [1.12–14.87], 5.39 [1.27–27.36]; P = 0.031, P = 0.021). This study provides a comprehensive overview of the associations between identified variables and the vaginal microbiome, representing an important step toward understanding of environment-microbe-host interactions.
Syk inhibitor attenuates lupus in FcγRIIb−/− mice through the Inhibition of DNA extracellular traps from macrophages and neutrophils via p38MAPK-dependent pathway
Authors: Sae-khow Kritsanawan , Charoensappakit Awirut , Udompornpitak Kanyarat , Saisorn Wilasinee , Issara-Amphorn Jiraphorn , Palaga Tanapat , Leelahavanichkul Asada 
Published: February 2025

Abstract
Spleen tyrosine kinase (Syk), an important hub of immune signaling, is activated by several signalings in active lupus which could be interfered by Syk inhibitor but is still not completely evaluated in innate immune cells associated with lupus activity. Hence, a Syk inhibitor (fostamatinib; R788) was tested in vivo using Fc gamma receptor-deficient (FcγRIIb−/−) lupus mice and in vitro (macrophages and neutrophils). After 4 weeks of oral Syk inhibitor, 40 week-old FcγRIIb−/− mice (a full-blown lupus model) demonstrated less prominent lupus parameters (serum anti-dsDNA, proteinuria, and glomerulonephritis), systemic inflammation, as evaluated by serum TNFa, IL-6, and citrullinated histone H3 (CitH3), gut permeability defect, as indicated by serum FITC dextran assay, serum lipopolysaccharide (LPS), and serum (1 → 3)-β-D-glucan (BG), extracellular traps (ETs) and immune complex deposition in spleens and kidneys (immunofluorescent staining of CitH3 and immunoglobulin G) than FcγRIIb−/− mice with placebo. Due to the spontaneous elevation of LPS and BG in serum, LPS plus BG (LPS + BG) was used to activate macrophages and neutrophils. After LPS + BG stimulation, FcγRIIb−/− macrophages and neutrophils demonstrated predominant abundance of phosphorylated Syk (Western blotting), and the pro-inflammatory responses (CD86 flow cytometry analysis, supernatant cytokines, ETs immunofluorescent, and flow cytometry-based apoptosis). With RNA sequencing analysis and western blotting, the Syk-p38MAPK-dependent pathway was suggested as downregulating several inflammatory pathways in LPS + BG-activated FcγRIIb−/− macrophages and neutrophils. Although both inhibitors against Syk and p38MAPK attenuated macrophage and neutrophil inflammatory responses against LPS + WGP, the apoptosis inhibition by p38MAPK inhibitor was not observed. These results suggested that Syk inhibitor (fostamatinib) improved the severity of lupus caused by FcγRIIb defect partly through Syk-p38MAPK anti-inflammation that inhibited both ET formation and cytokine production from innate immune cells.
Blue benzoquinone from scorpion venom shows bactericidal activity against drug-resistant strains of the priority pathogen Acinetobacter baumannii
Authors: Gallegos-Monterrosa Ramses , Cid-Uribe Jimena I. , Delgado-Prudencio Gustavo , Pérez-Morales Deyanira , Banda María M. , Téllez-Galván Alexis , Carcamo-Noriega Edson N. , Garza-Ramos Ulises , Zare Richard N. , Possani Lourival D. , Bustamante Víctor H. 
Published: February 2025

Abstract
Antibiotic-resistant bacteria pose a significant global health threat, particularly pathogens resistant to last-resort antibiotics, such as those listed as priority pathogens by the World Health Organization. Addressing this challenge requires the development of novel antimicrobial agents. Previously, we identified a blue 1,4-benzoquinone isolated from the venom of the Mexican scorpion Diplocentrus melici as a potent antimicrobial compound effective against Staphylococcus aureus and Mycobacterium tuberculosis. Moreover, we devised a cost-effective synthetic route for its production. In this study, we demonstrate that the blue benzoquinone exhibits antibacterial activity against additional pathogens, including the priority pathogen Acinetobacter baumannii. Notably, the compound effectively killed clinical strains of A. baumannii resistant to multiple antibiotics, including carbapenem and colistin. Furthermore, A. baumannii did not develop resistance to the benzoquinone even after multiple growth cycles under sub-inhibitory concentrations, unlike the tested antibiotics. These findings underscore the potential of this blue benzoquinone as a lead compound for the development of a new class of antibiotics targeting multidrug-resistant bacteria.
RNA methyltransferase SPOUT1/CENP-32 links mitotic spindle organization with the neurodevelopmental disorder SpADMiSS
Authors: Dharmadhikari Avinash V. , Abad Maria Alba , Khan Sheraz , Maroofian Reza , Sands Tristan T. , Ullah Farid , Samejima Itaru , Shen Yanwen , Wear Martin A. , Moore Kiara E. , Kondakova Elena , Mitina Natalia , Schaub Theres , Lee Grace K. , Umandap Christine H. , Berger Sara M. , Iglesias Alejandro D. , Popp Bernt , Abou Jamra Rami , Gabriel Heinz , Rentas Stefan , Rippert Alyssa L. , Gray Christopher , Izumi Kosuke , Conlin Laura K. , Koboldt Daniel C. , Mosher Theresa Mihalic , Hickey Scott E. , Albert Dara V. F. , Norwood Haley , Lewanda Amy Feldman , Dai Hongzheng , Liu Pengfei , Mitani Tadahiro , Marafi Dana , Eker Hatice Koçak , Pehlivan Davut , Posey Jennifer E. , Lippa Natalie C. , Vena Natalie , Heinzen Erin L. , Goldstein David B. , Mignot Cyril , de Sainte Agathe Jean-Madeleine , Al-Sannaa Nouriya Abbas , Zamani Mina , Sadeghian Saeid , Azizimalamiri Reza , Seifia Tahere , Zaki Maha S. , Abdel-Salam Ghada M. H. , Abdel-Hamid Mohamed S. , Alabdi Lama , Alkuraya Fowzan Sami , Dawoud Heba , Lofty Aya , Bauer Peter , Zifarelli Giovanni , Afzal Erum , Zafar Faisal , Efthymiou Stephanie , Gossett Daniel , Towne Meghan C. , Yeneabat Raey , Perez-Duenas Belen , Cazurro-Gutierrez Ana , Verdura Edgard , Cantarin-Extremera Veronica , Marques Ana do Vale , Helwak Aleksandra , Tollervey David , Wontakal Sandeep N. , Aggarwal Vimla S. , Rosenfeld Jill A. , Tarabykin Victor , Ohta Shinya , Lupski James R. , Houlden Henry , Earnshaw William C. , Davis Erica E. , Jeyaprakash A. Arockia , Liao Jun 
Published: February 2025

Abstract

SPOUT1/CENP-32 encodes a putative SPOUT RNA methyltransferase previously identified as a mitotic chromosome associated protein. SPOUT1/CENP-32 depletion leads to centrosome detachment from the spindle poles and chromosome misalignment. Aided by gene matching platforms, here we identify 28 individuals with neurodevelopmental delays from 21 families with bi-allelic variants in SPOUT1/CENP-32 detected by exome/genome sequencing. Zebrafish spout1/cenp-32 mutants show reduction in larval head size with concomitant apoptosis likely associated with altered cell cycle progression. In vivo complementation assays in zebrafish indicate that SPOUT1/CENP-32 missense variants identified in humans are pathogenic. Crystal structure analysis of SPOUT1/CENP-32 reveals that most disease-associated missense variants are located within the catalytic domain. Additionally, SPOUT1/CENP-32 recurrent missense variants show reduced methyltransferase activity in vitro and compromised centrosome tethering to the spindle poles in human cells. Thus, SPOUT1/CENP-32 pathogenic variants cause an autosomal recessive neurodevelopmental disorder: SpADMiSS (SPOUT1 Associated Development delay Microcephaly Seizures Short stature) underpinned by mitotic spindle organization defects and consequent chromosome segregation errors.
Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings
Authors: Zheng Sean L. , Jurgens Sean J. , McGurk Kathryn A. , Xu Xiao , Grace Chris , Theotokis Pantazis I. , Buchan Rachel J. , Francis Catherine , de Marvao Antonio , Curran Lara , Bai Wenjia , Pua Chee Jian , Tang Hak Chiaw , Jorda Paloma , van Slegtenhorst Marjon A. , Verhagen Judith M. A. , Harper Andrew R. , Ormondroyd Elizabeth , Chin Calvin W. L. ,   HCM GWAS Collaborators, de Marvao Antonio , van Slegtenhorst Marjon A. , Ware James S. , Pantazis Antonis , Baksi John , Halliday Brian P. , Matthews Paul , Pinto Yigal M. , Walsh Roddy , Amin Ahmad S. , Wilde Arthur A. M. , Cook Stuart A. , Prasad Sanjay K. , Barton Paul J. R. , O’Regan Declan P. , Lumbers R. T. , Goel Anuj , Tadros Rafik , Michels Michelle , Watkins Hugh , Bezzina Connie R. , Ware James S. 
Published: February 2025

Abstract
Hypertrophic cardiomyopathy (HCM) is an important cause of morbidity and mortality, with pathogenic variants found in about a third of cases. Large-scale genome-wide association studies (GWAS) demonstrate that common genetic variation contributes to HCM risk. Here we derive polygenic scores (PGS) from HCM GWAS and genetically correlated traits and test their performance in the UK Biobank, 100,000 Genomes Project, and clinical cohorts. We show that higher PGS significantly increases the risk of HCM in the general population, particularly among pathogenic variant carriers, where HCM penetrance differs 10-fold between those in the highest and lowest PGS quintiles. Among relatives of HCM probands, PGS stratifies risks of developing HCM and adverse outcomes. Finally, among HCM cases, PGS strongly predicts the risk of adverse outcomes and death. These findings support the broad utility of PGS across clinical settings, enabling tailored screening and surveillance and stratification of risk of adverse outcomes.
The microRNA-6510 as a potential tumor suppressor in head and neck cancer
Authors: Sobecka-Giel Agnieszka , Ostrowska Kamila , Golusinski Wojciech , Suchorska Wiktoria M. , Masternak Michal M. , Golusinski Pawel 
Published: February 2025

Abstract
Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common cancer worldwide, with approximately 830,000 new cases and 430,000 deaths reported annually. Due to their heterogeneity, these neoplasms differ in their clinical course and response to the therapy. Therefore, it has become imperative to identify specific biological molecules that can potentially establish novel prognostic markers or targets for molecular therapy of HNSCC. MicroRNAs are a class of short, non-coding RNAs that function as post-transcriptional regulators of genes expression. They have been shown to be directly involved in oncogenesis, acting as tumor suppressors or oncogenes. Our previous study demonstrated that miRNA hsa-miR-6510-3p is significantly downregulated in tumor tissue compared to histologically normal tissue from HNSCC patients. Its significant downregulation in tumor tissue is associated with lower chances for recovery and patient’s survival. This study aimed to determine the biological role of miR-6510-3p in HNSCC pathogenesis and its impact on biological processes occurring in cancer cells such as cell cycle, cell proliferation, migration or induction of cell death. We have also examined the impact of the miR-6510-3p on expression of cancer stem cell phenotype markers as well as on sensitivity of HNSCC cells to ionizing radiation. We observed that transfection of HNSCC cells with hsa-miR-6510-3p causes the cell cycle arrest in G2/M phase and is associated with a decrease of cell proliferation, migration and colony-forming ability of cancer cells. We have also demonstrated that hsa-miR-6510-3p induces cell death, increases the sensitivity of HNSCC cells to ionizing radiation and causes a loss of the stemness properties responsible for the occurrence of metastases and relapses of the disease. These results indicated the importance of miR-6510-3p as a marker and a driver of HNSCC disease.
The effects of an unfamiliar experimenter on proactive and reactive control in children
Authors: Frick Aurélien , Belletier Clément , Tan Wenjia , Meng Ning , Zhou Qiang , Christie Stella , Camos Valérie 
Published: February 2025

Abstract
Cognitive control development across childhood is critical for later academic achievement. Despite recent advances in the comprehension of how the context influences cognitive control development, no study has ever addressed whether one of the most frequent contextual features of children’s lives (i.e., the presence of another person) impacts control engagement. Here, 123 Chinese children aged 5 and 9 years-old performed, either in the presence of an experimenter or alone, an AX-CPT, a task assessing reactive and proactive control. We found that children were overall negatively affected by the experimenter presence in terms of latencies but not of accuracy. Further, when analysing the trial types separately, we observed that this effect mainly concerned trials requiring children to engage more proactive control and was greater for younger than older children. These results indicate that direct social factors such as the presence of an unfamiliar experimenter seem to modulate cognitive control performance. Future research should continue to examine these effects in the light of the numerous existing social presence theories in order to unravel what are the cognitive mechanisms affected by social presence in childhood.