bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormal TPM2 expression is involved in regulation of atherosclerosis progression via mediating RhoA signaling <i>in vitro</i>
Authors: Zhang Jimei , Zhang Chonghong , Miao Li , Meng Zimin , Gu Ning , Song Guifang 
Published: July 2021

IntroductionOx-LDL (oxidized low-density lipoprotein)-induced endothelial cell injury and dysfunction of vascular smooth muscle cells play critical roles in the development of atherosclerosis (AS). Tropomyosin 2 (TPM2) has been implicated in cardiac diseases, but its critical role and regulatory mechanism in AS progression have not yet been elucidated.Material and methodsThe expression of TPM2 was investigated in AS tissues. Ox-LDL was used to construct an AS in vitro model based on endothelial and vascular smooth muscle cells (HAECs and VSMCs). An overexpression assay was performed to evaluate the role of TPM2 in AS. Meanwhile, the involvement of the RhoA pathway in TPM2-mediated AS progression was evaluated using narciclasine.ResultsTropomyosin 2 was dramatically upregulated in both AS tissues and ox-LDL-induced HAECs. Overexpression of TPM2 attenuated ox-LDL-stimulated cell growth depression, inflammatory and adhesive responses in HAECs, as well as oxidative stress and mitochondrial dysfunction. Additionally, VSMCs, impacted by TPM2-overexpressed HAECs, showed alleviated cellular processes which were abnormally activated by ox-LDL. Furthermore, depressed activation of the RhoA pathway was found in TPM2-overexpressed HAECs and activating the signaling rescued these effects of TPM2 exerted on ox-LDL-stimulated HAECs and VSMCs.ConclusionsTPM2 had an advantageous impact on ox-LDL-induced AS progression in vitro by mediating the RhoA pathway. This evidence might contribute to the therapy of AS.
Design and implementation of monitoring system for paralysis patient using IoT
Authors: Beenish Hira , Nasar Fakeha , Sheikh Ehsan , Fahad Muhammad 
Published: July 2021

Internet of things represents a catch line of smart applications. At the same time it plays a leading role in the health care systems, as it provides the connectivity of the distant patients, who are not able to express their concerns. In this modern era there are a lot of technologies that are being used in different healthcare fields for paralyzed people. This paper proposed a model for paralyzed patient by considering Arduino with the integration of gyro sensors for the patient hand and finger movement. Patient can easily be connected with this device by sending his message to caretaker only by moving their hands into respective directions, or they can send their message by moving their fingers and feet. Through this device paralyzed patient will be able to convey their messages to caretakers, so they can assist the patient. This system will enhance the medical care to those patients who are even not able to convey their message.
Aplikasi Pendataan Hasil Survei Ubinan Tanaman Pangan Pada Badan Pusat Statistik Kabupaten Bireuen
Authors: Zulkarnaini Iskandar 
Published: July 2021

Pengolahan data hasil pertanian di dinas BPS Bireuen masih menggunakan sistem yang manual. Data diolah dengan menggunakan program Excel. Tidak ada klasifikasi daerah berdasarkan jumlah hasil tanaman pangan yang dihitung dari rata-rata dalam satu kabupaten. Bagi penyuluh pertanian, klasifikasi derah tersebut sangat membantu dalam proses bimbingan dan pengarahan terhadap petani dalam mengembangkan pengolahan lahan pertanian. Dengan adanya permasalahan tersebut penulis membuat sebuah aplikasi yang dapat digunakan dalam pengolahan data hasil survei tanaman pangan pada BPS Bireuen, sistem ini dikembangkan dengan menggunakan bahasa pemrograman PHP dan Mysql. Sedangkan untuk perancangan menggunakan Diagram konteks, DFD dan ERD. Output dari sistem ini berupa informasi hasil pertanian pada BPS Bireuen
ADHERENCE TO MANAGEMENT IN PATIENTS WITH END STAGE RENAL DISEASE
Authors: Raashid Sheharyar , Arshad Abdul Rehman , Mir Abdul Wahab 
Published: July 2021

Objective: To document overall adherence to haemodialysis, medications, fluid restriction and dietary prescription in patients with end-stage renal disease and to study factors that could predict poor adherence.
Study Design: Cross-sectional analytical study.
Place and Duration of Study: Department of Nephrology, Pak Emirates Military Hospital, Rawalpindi, from Jul to Sep 2018.
Methodology: Adult patients on haemodialysis for at least three months were selected using consecutive sampling technique. Patients with acute kidney injury, patients on haemodialysis for less than 3 months, those on infrequent haemodialysis and unwilling patients were excluded. Demographic data was recorded. Adherence to management was assessed by administering End Stage Renal Disease Adherence Questionnaire in direct face- to-face interviews.
Results: There were a total of 101 patients having a mean age of 51.05 ± 13.80 years. Median haemodialysis vintage was 9 months (interquartile range 3-24 months). Mean adherence scores were 970.54 ± 149.43. Mean perception scores were 7.22 ± 1.37. Only 49 (48.51%) patients had good adherence, whereas 52 (51.49%) had poor adherence to management. Increasing age was associated with poor adherence (β=-0.038; Odds Ratio=0.963, 95% CI 0.928- 1.000, p=0.048). No other demographic parameter could predict poor adherence.
Conclusion: Non-adherence to different aspects of management plan was a significant problem, more so in younger patients.
COMPARISON OF INTRA-ARTICULAR METHYLPREDNISOLONE AND KETOROLAC INJECTIONS IN IMPROVING RANGE OF MOTION FOR DIFFERENT SHOULDER JOINT DISORDERS
Authors: Matee Sumeera , Anwar Wasif , Wahid Sami , Ayaz Saeed Bin , Shahid Rana , Sheikh Nadeem Ahmed 
Published: July 2021

Objective: To compare the efficacy of intra-articular injection of methyl prednisolone with ketorolac for improvement in range of motion in various shoulder joint disorders.
Study Design: Quasi-experimental study.
Place and Duration of Study: Departments of Internal and Rehabilitation Medicine, Combined Military Hospital Mangla, from Nov 2018 to May 2019.
Methodology: Through non-probability consecutive sampling, patients with shoulder disorders were enrolled in the study and divided into two groups. Group A received intra articular corticosteroid injection and group B received intra-articular Ketorolac injection. Outcome was measured in terms of improvement in shoulder range of motion.
Results: A total of 60 patients were selected, 40 (66.7%) male and 20 (33.3%) female. 30 (50%) patients had adhesive capsulitis, 24 (40%) had rotator cuff syndrome and 6 (10%) had impingement syndrome. 24 patients received methyl prednisolone acetate injection while 36 received ketorolac injection. There was no significant difference in the mean gain in flexion, extension, abduction, internal or external rotation between both groups (p=0.224, p=0.261, p=0.884, p=0.238, and p=0.584 respectively).
Conclusion: There was no significant difference in efficacy of corticosteroid and ketorolac when injected intra-articularly in shoulder joint disorders.
DIAGNOSTIC ACCURACY OF 99 MTC LABELLED UBIQUICIDIN (29-41) SPECT/CT FOR DIAGNOSIS OF OSTEOMYELITIS IN DIABETIC FOOT
Authors: Atif Muhammad , Hussain Fida , Dar Zaigham Salim , Khatoon Jameela , Ajmal Saadia , Adil Muhammad 
Published: July 2021

Objective: To determine diagnostic accuracy of 99mTc labelled Ubiquicidin (29-41) SPECT/CT for detection of osteomyelitis in diabetic foot patients by taking bone biopsy as gold standard.
Study Design: Cross-sectional validation study.
Place and Duration of Study: Nuclear Medical Centre, Armed Forces Institute of Pathology, from Apr 2017 to Mar 2018.
Methodology: Study assessed 122 patients of both genders, aged between 30-80 years (mean age=55.3 years), presenting with diabetic foot ulcers having suspicion of osteomyelitis, by 99mTc-Ubiquicidin (29-41) SPECT/CT followed by bone biopsy (histopathology and culture) taken as gold standard.
Results: Among 122 patients [94 male (77%) and 28 female (23%)], osteomyelitis was histopathologically confirmed in 113 patients. 107 out of these patients were positive for osteomyelitis on 99mTc-UBI (29-41) SPECT/CT (true positives) while 6 were false negative. Out of 9 patients declared negative for osteomyelitis on histopathology and culture, 8 were negative on 99mTc-UBI (29-41) SPECT/CT as well (true negative) while only 1 case came out to be positive (false positive). Thus, the 99mTc-UBI (29-41) scan showed 94.6% sensitivity, 88.89% specificity, 99% positive predictive value, 57% negative predictive value with overall 94.2% diagnostic accuracy.
Conclusion: 99mTc labelled Ubiquicidin (29-41) SPECT/CT scan can precisely localize infective focus, in diabetic foot osteomyelitis, with simultaneous discrimination between bone and soft tissues.
Esticando a verdade sem alcançar a contradição: o caso do dialeteísmo
Authors: Melo Ederson Safra , Arenhart Jonas Rafael Becker 
Published: July 2021

Dialeteias são contradições verdadeiras. Dialeteísmo é a visão de que há dialeteias e dialeteístas são aqueles que defendem tal visão. Uma das principais motivações para o dialeteísmo encontra-se nos paradoxos semânticos, como o paradoxo do Mentiroso. A sentença do mentiroso, na abordagem dialeteísta, instancia uma dialeteia. O problema é: como aceitar contradições verdadeiras? Como dialeteísmo é a visão que algumas, mas não todas, contradições são verdadeiras, o dialeteísmo demanda um tratamento paraconsistente. Porém, não é qualquer sistema paraconsistente que pode ser aplicado ao dialeteísmo. A interpretação do símbolo de negação deve ser um operador formador de contradição (ofc) com o sentido relevante para a aplicação dialeteísta. Especificamente, na versão de dialeteísmo que discutiremos nesse artigo, defendida por Graham Priest, temos que, para que o dialeteísmo faça sentido, a negação da lógica subjacente deve atender a dois requisitos: (i) ser um ofc e (ii) não ser explosiva. A Lógica do Paradoxo (LP) tem sido apontada como a lógica adequada ao dialeteísmo. Veremos que, a fim de lidar com contradições sem trivialidade, dialeteístas “esticam” a verdade de modo que a verdade possa incluir, em alguns casos, a falsidade também. Nesse caso, haveria sentenças verdadeiras e falsas, chamadas de aglutinações de valores de verdade (truth-value gluts). Em LP, aglutinações de valores de verdade são fundamentais para garantir os requisitos (i) e (ii). Todavia, vamos argumentar que tal procedimento de esticar a verdade, permitindo aglutinações, garante a paraconsistência ao custo de distorcer a interpretação da noção de contradição envolvida no dialeteísmo. Especificamente, tal distorção enfraquece a interpretação da negação comprometendo o sentido de contradição relevante para o dialeteísmo. Vamos argumentar que as próprias restrições dialeteístas a uma compreensão adequada do Mentiroso mostram que as condições (i) e (ii) são incompatíveis e que, com isso, o projeto dialeteísta enfrenta consideráveis obstáculos.
History and current status of Marek's disease in turkeys
Authors: Shehata Awad A. , Lüschow Dörte , M. Hafez Hafez 
Published: July 2021

Marek's disease (MD), caused by a highly contagious and oncogenic herpesvirus, causes immunosuppression and tumors in chickens. Although several reports on the occurring lymphomas (MD-like conditions) in turkeys have been published, less attention has been paid to the disease in this species. Recently, Marek's disease virus (MDV) has been demonstrated in lymphomatous tumors in commercial turkeys in several countries. The present review aimed to describe the past and recent situation of MD in turkeys, including clinical picture and methods used for diagnosis. Additionally, three hypotheses that might explain the emergence of MDV in turkeys, including virus evolution and evolution of MDV variants, modern hybrid turkeys, and raising of turkeys close to chickens, were discussed. The pathogenesis of MDV infection in turkeys remains unclear, and further investigations are necessary. Although herpesvirus of turkey (HVT) vaccine didn't protect turkeys against challenge with a virulent MDV, Rispens strain is effective, highlighting the need for further assessment of the effectiveness of MDV vaccines in turkeys.
Microgrid Communication and Security: State-Of-The-Art and Future Directions
Authors: Bohani Farah Aqilah , Yahya Sitti Rachmawati , Sheikh Abdullah Siti Norul Huda 
Published: July 2021

The microgrid communication network with proper connectivity among microgrid resources is play important role to maintain a stability and reliability of the microgrid. Application of suitable communication network and protocol and highlighted the best security measurement is one of the elements to achieve those broad objectives. The communication network and protocol that has been implemented in existing microgrid has different types and objective which is depend on specific application. To secure the communication network and protocol, many security approaches is proposed. In this paper, a review of microgrid communication and its security is shown and future direction of communication network and protocol with its security also provided.
Coastal complexity of the Antarctic continent
Authors: Porter-Smith Richard , McKinlay John , Fraser Alexander D. , Massom Robert A. 
Published: July 2021

Abstract. The Antarctic outer coastal margin (i.e. the coastline itself or the terminus or front of ice shelves, whichever is adjacent to the ocean) is a key
interface between the ice sheet and terrestrial environments and the Southern Ocean. Its physical configuration (including both length scale of
variation, orientation, and aspect) has direct bearing on several closely associated cryospheric, biological, oceanographical, and ecological
processes, yet no study has quantified the coastal complexity or orientation of Antarctica's coastal margin. This first-of-a-kind characterization
of Antarctic coastal complexity aims to address this knowledge gap. We quantify and investigate the physical configuration and complexity of
Antarctica's circumpolar outer coastal margin using a novel technique based on ∼ 40 000 random points selected along a vector coastline
derived from the MODIS Mosaic of Antarctica dataset. At each point, a complexity metric is calculated at length scales from 1 to 256 km,
giving a multiscale estimate of the magnitude and direction of undulation or complexity at each point location along the entire coastline. Using a
cluster analysis to determine characteristic complexity “signatures” for random nodes, the coastline is found to comprise three basic groups or
classes: (i) low complexity at all scales, (ii) most complexity at shorter scales, and (iii) most complexity at longer scales. These classes are
somewhat heterogeneously distributed throughout the continent. We also consider bays and peninsulas separately and characterize their multiscale
orientation. This unique dataset and its summary analysis have numerous applications for both geophysical and biological studies. All these data are
referenced by https://doi.org/10.26179/5d1af0ba45c03 (Porter-Smith et al., 2019) and are available free of charge at http://data.antarctica.gov.au
(last access: 7 June 2021).
UAV-based very high resolution point cloud, digital surface model and orthomosaic of the Chã das Caldeiras lava fields (Fogo, Cabo Verde)
Authors: Vieira Gonçalo , Mora Carla , Pina Pedro , Ramalho Ricardo , Fernandes Rui 
Published: July 2021

Abstract. Fogo in the Cabo Verde archipelago off western Africa is one of the most prominent and active ocean island volcanoes on Earth, posing an important
hazard both to local populations and at a regional level. The last eruption took place between 23 November 2014 and 8 February 2015 in the Chã
das Caldeiras area at an elevation close to 1800 ma.s.l. The eruptive episode gave origin to extensive lava flows that almost fully
destroyed the settlements of Bangaeira, Portela and Ilhéu de Losna. During December 2016 a survey of the Chã das Caldeiras area was
conducted using a fixed-wing unmanned aerial vehicle (UAV) and real-time kinematic (RTK) global navigation satellite system (GNSS), with the objective of improving the terrain models
and visible imagery derived from satellite platforms, from metric to decimetric resolution and accuracy. The main result is a very high resolution
and quality 3D point cloud with a root mean square error of 0.08 m in X, 0.11 m in Y and 0.12 m in Z, which fully
covers the most recent lava flows. The survey comprises an area of 23.9 km2 and used 2909 calibrated images with an average ground
sampling distance of 7.2 cm. The dense point cloud, digital surface models and orthomosaics with 25 and 10 cm resolutions, a
50 cm spaced elevation contour shapefile, and a 3D texture mesh, as well as the full aerial survey dataset are provided. The delineation of the
2014/15 lava flows covers an area of 4.53 km2, which is smaller but more accurate than the previous estimates from 4.8 to
4.97 km2. The difference in the calculated area, when compared to previously reported values, is due to a more detailed mapping of the
flow geometry and to the exclusion of the areas corresponding to kīpukas (outcrops surrounded by lava flows). Our study provides a very
high resolution dataset of the areas affected by Fogo's latest eruption and is a case study supporting the advantageous use of UAV aerial
photography surveys in disaster-prone areas. This dataset provides accurate baseline data for future eruptions, allowing for different applications
in Earth system sciences, such as hydrology, ecology and spatial modelling, as well as to planning. The dataset is available for download at
https://doi.org/10.5281/zenodo.4718520 (Vieira et al., 2021).
The evolution of stable silicon isotopes in a coastal carbonate aquifer on Rottnest Island, Western Australia
Authors: Martin Ashley N. , Meredith Karina , Baker Andy , Norman Marc D. , Bryan Eliza 
Published: July 2021

Abstract. Dissolved silicon (dSi) is a key nutrient in the oceans, but data regarding Si isotopes in coastal aquifers are not widely available. Here we investigate the Si isotopic composition of 12 fresh and 16 saline groundwater samples from Rottnest Island, Western Australia, which forms part of the world's most extensive aeolianite deposit (the Tamala Limestone formation). In total, two bedrock samples were also collected from Rottnest Island for Si isotope analysis. The δ30Si values of groundwater samples ranged from −0.4 ‰ to +3.6 ‰ with an average
+1.6 ‰, and the rock samples were −0.8 ‰ and −0.1 ‰. The increase in δ30Si values in fresh
groundwater is attributed to the removal of the lighter Si isotopes into secondary minerals and potentially also adsorption onto Fe
(oxy)hydroxides. The positive correlations between δ30Si values and dSi concentrations (ρ = 0.59; p = 0.02) and
δ30Si values and Cl, but not dSi and Cl concentrations, are consistent with vertical mixing between the younger fresh groundwater
and the deeper groundwater, which have undergone a greater degree of water–rock interactions. This has produced a spatial pattern in
δ30Si across the aquifer due to the local hydrogeology, resulting in a correlation between δ30Si and tritium
activities when considering all groundwater types (ρ = −0.68; p = 0.0002). In the deeper aquifer, the inverse correlation between dSi and Cl concentrations (ρ = −0.79; p = 0.04) for the more saline groundwater is attributed to groundwater mixing with local
seawater that is depleted in dSi (< 3.6 µM). Our results from this well-constrained island aquifer system demonstrate that stable Si isotopes usefully reflect the degree of water–aquifer interactions, which is related to groundwater residence time and local hydrogeology. Our finding that lithogenic Si dissolution occurs in the freshwater lens and the freshwater–seawater transition zone on Rottnest Island appears to supports the recent inclusion of a marine–submarine groundwater discharge term in the global dSi mass balance. Geologically young carbonate aquifers, such as Rottnest Island, may be an important source of dSi in coastal regions with low riverine input and low oceanic dSi concentrations.
The &lt;i&gt;Staphylococcus aureus&lt;/i&gt; toxin–antitoxin system YefM–YoeB is associated with antibiotic tolerance and extracellular dependent biofilm formation
Authors: Qi Xinyu , Brothers Kimberly M. , Ma Dongzhu , Mandell Jonathan B. , Donegan Niles P. , Cheung Ambrose L. , Richardson Anthony R. , Urish Kenneth L. 
Published: July 2021

Abstract. The high antibiotic tolerance of Staphylococcus aureus biofilms is associated with challenges
for treating periprosthetic joint infection. The toxin–antitoxin system,
YefM–YoeB, is thought to be a regulator for antibiotic tolerance, but its
physiological role is unknown. The objective of this study was to determine
the biofilm and antibiotic susceptibility phenotypes associated with S. aureus yoeB
homologs. We hypothesized the toxin–antitoxin yoeB homologs contribute to
biofilm formation and antibiotic susceptibility. Disruption of yoeB1 and
yoeB2 resulted in decreased biofilm formation in comparison to Newman and JE2
wild-type (WT) S. aureus strains. In comparison to yoeB mutants, both Newman and JE2 WT
strains had higher polysaccharide intercellular adhesin (PIA) production.
Treatment with sodium metaperiodate increased biofilm formation in Newman
WT, indicating biofilm formation may be increased under conditions of
oxidative stress. DNase I treatment decreased biofilm formation in Newman
WT but not in the absence of yoeB1 or yoeB2. Additionally, WT strains had a higher
extracellular DNA (eDNA) content in comparison to yoeB mutants but no
differences in biofilm protein content. Moreover, loss of yoeB1 and yoeB2 decreased
biofilm survival in both Newman and JE2 strains. Finally, in a neutropenic
mouse abscess model, deletion of yoeB1 and yoeB2 resulted in reduced bacterial
burden. In conclusion, our data suggest that yoeB1 and yoeB2 are associated with
S. aureus planktonic growth, extracellular dependent biofilm formation, antibiotic
tolerance, and virulence.
Ergenler İçin Sosyal Medya Mahremiyetini Koruma Becerileri Ölçeği’nin Geliştirilmesi
Authors: Gelbal Odabaş Özlem , İlhan Tahsin , Kılıçer Kerem 
Published: July 2021

Amaç: Çalışmanın amacı, ergenlerin sosyal medyada mahremiyeti koruma becerilerinin değerlendirilebileceği geçerli ve güvenilir bir ölçek geliştirmektir.
Yöntem:	Araştırma, yaşları 11-18 arasında olan toplam 790 ortaokul ve lise öğrencisi (K:435, E:355) ile yürütülmüştür. Madde havuzunu oluşturmak amacıyla 15-18 yaş arası 10 öğrenciyle (K:5, E:5) bireysel görüşme yapılmıştır. Verilerin toplanmasında, Ergenler İçin Sosyal Medya Mahremiyetini Koruma Becerileri Ölçeği, Öğrenci Siber Sağlık Ölçeği’nin alt boyutları olarak geliştirilen Çevrimiçi Mahremiyet Ölçeği-Çevrimiçi Güvenlik Ölçeği kullanılmıştır.
Bulgular: Faktör analizi sonucunda 27 maddeli ölçeğin açıkladığı toplam varyansın % 46.33 olduğu, üç faktörlü bir yapı sergilediği, birinci ve ikinci düzey doğrulayıcı faktör analizinin uyum indekslerinin iyi uyuma işaret ettiği gözlenmiştir. Çevrimiçi mahremiyet ölçeği ve çevrimiçi güvenlik ölçeği ile yapılan ölçüt dayanaklı geçerlilik çalışmaları sonucunda elde edilen korelasyon değerleri ölçeğin geçerliliğini desteklemektedir. Ölçeğin Cronbach Alpha güvenirlik katsayısı .90 ve test- tekrar test güvenirlik katsayısı .78’dir.
Sonuç: Ergenler İçin Sosyal Medya Mahremiyetini Koruma Becerileri Ölçeği’nin geçerli ve güvenilir bir ölçme aracı olduğu ve sosyal medya mahremiyetini koruma becerisi değişkeninin ölçülmesinde kullanılabileceği düşünülmektedir.