bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facile fabrication and structural elucidation of lignin based macromolecular green composites for multifunctional applications
Authors: Pathayappurakkal Mohanan Dhilin , Pathayappurakkal Mohan Nimegha , Selvasudha Nandakumar , Thekkilaveedu Saranya , Kandasamy Ruckmani 
Published: June 2021

AbstractThe present work deals with the preparation and characterization of lignin based macromolecular polymeric composites and applications thereof. Here lignin is complexed with pectin and/ or gellan gum, to form two different macromolecular green composites LP and LPG. The best ratios screened out through evaluation of nanoparticle characterization and rheology, then confirmed by surface morphology. The superior thermal stability is proved by DSC analysis. The reaction groups involving in complexation are confirmed by FT‐IR spectroscopic evaluation where the methoxy or methyl group of lignin interacts with the hydroxyl group of pectin and gellan gum to form nanocomposites. The reduced particle size and surface charge confirm the complexation due to interaction between ionizable functional groups. The applications of these composites are validated by their dye adsorption capacity and anti‐microbial properties (after loading of green silver nanoparticles) which proves the multifunctional properties of novel composites. The maximum dye removal efficiency of both composites is independent of initial dye concentration. Dye adsorption capacity is best fitted by Freundlich adsorption isotherms that follow pseudo‐second‐order adsorption kinetics. The antibacterial study of developed silver nanoparticle loaded and unloaded composites shows wide spectrum activity against E. coli and S. aureus, with higher inhibition efficiency against gram‐negative organism.
Passion for the past: Effect of charity appeals and nostalgia on clothing donation intentions
Authors: Kim Seeun , Childs Michelle L. 
Published: June 2021

AbstractAlthough consumers' clothing disposal behavior is of considerable interest in the research community, there is a lack of empirical studies that thoroughly examine how consumers respond to charity messages in the context of clothing donation. Drawing on construal level theory, this study aims to contribute to the topic by examining the interplay of charity appeals (other‐ vs. self‐benefit) and social emotion (nostalgia vs. control) on clothing donation behavior. Our results show that consumers reveal greater donation intentions toward other‐benefit appeals than self‐benefit appeals. Also, the results indicate that high nostalgic consumers tend to reveal greater donation intentions than low nostalgic consumers (Study 1). Further, the charity appeals effect is moderated by situationally induced nostalgia. Specifically, we found that the congruent matching of other‐benefit appeals with nostalgia increases donation intentions (Study 2). These findings provide important implications, both theoretically and managerially, by systematically highlighting how different charity appeals can be beneficial in charitable advertising, depending on nostalgia highlighting the sentimental longing for the past.
Green extraction of rice bran proteins and full revaluation of the remaining by‐products
Authors: Rajchman Mikaela , Gutiérrez María Belén , Curutchet Ana , Cozzano Sonia 
Published: June 2021

AbstractBackground and objectivesFull fat rice bran is a highly nutritional by‐product of white rice production underutilized at present, with 90% of it being employed as a cheap feedstock. This study aimed to apply a water‐and‐citric‐acid extraction method as a green technique to obtain a protein concentrate from rice bran. Extractions were carried out through a heat treatment, varying time and temperature, and optimized using response surface methodology based on protein purity, followed by citric acid (50% w/w) precipitation. Co‐products obtained after the procedure were also characterized to determine their functional properties.FindingsIncreasing temperature and time yielded higher protein purity, so 75 °C for 90 min was applied. Under these conditions, the protein concentrate contained 69.5% of protein, the supernatant had 60.6% of soluble carbohydrates, and their corresponding bioaccessible fraction had better antioxidant capacity than that of the bran. Finally, the sediment was similar in composition and functional properties to rice bran, which means high dietary fiber content.ConclusionsA protein concentrate, hypoallergenic and with high nutritional value, and two other functional fractions could be obtained through this environmentally friendly method.Significance and noveltyThis technique could help meet the demand of proteins throughout the world.
Organocatalytic Strategies for the Development of the Enantioselective Inverse‐electron‐demand Hetero‐Diels‐Alder Reaction
Authors: Laina‐Martín Víctor , Fernández‐Salas Jose A. , Alemán José 
Published: June 2021

AbstractCycloaddition reactions, in particular Diels‐Alder reactions, have attracted a lot of attention from organic chemists since they represent one of the most powerful methodologies for the construction of carbon‐carbon bonds. In particular, inverse‐electron‐demand hetero‐Diels‐Alder reactions have been an important breakthrough for the synthesis of heterocyclic compounds. Among all their variants, the organocatalytic enantioselective version has been widely explored since the asymmetric construction of diversely functionalized scaffolds under reaction conditions encompassed within the green chemistry field is of great interest. In this review, a profound revision on the latest advances on the organocatalytic asymmetric inverse‐electron demand hetero‐Diels‐Alder reaction is shown.
Native Chemical Ligation‐Based Fluorescent Probes for Cysteine and Aminopeptidase N Using meso‐thioester‐BODIPY
Authors: Lee Uisung , Kim Tae‐Il , Jeon Sungjin , Luo Yongyang , Cho Siyoung , Bae Jeehyeon , Kim Youngmi 
Published: June 2021

Abstractmeso‐Carboxyl‐BODIPY responds to small electronic changes resulting from acyl substitution reactions with a marked change in fluorescence. Herein, the minute changes that accompany the thioester to amide conversion encountered in native chemical ligation (NCL) are exploited in the construction of fluorescent “turn‐on” probes. Two fluorogenic probes, 1 a and 4, derived from a meso‐thioester‐BODIPY scaffold, were designed for the selective detection of cysteine (1 a) and aminopeptidase N (4), respectively. The aromatic (1 a) and aliphatic (4) thioesters of meso‐carboxyl‐BODIPY are nonfluorescent. However, specific analyte‐induced conversion to the meso‐amide derivative caused significant spectral changes and a dramatic fluorescence enhancement. Probe 1 a exhibited a large fluorescence “turn‐on” response with high selectivity toward cysteine via a tandem NCL reaction. Probe 4 was successfully applied to the monitoring and imaging of endogenous aminopeptidase N in live cancer cells.
High‐Pressure Reverse Osmosis for Industrial Water Recycling: Permeate‐Sided Pressure Drop as Performance‐Limiting Factor
Authors: Kleffner Christine , Braun Gerd , Antonyuk Sergiy 
Published: June 2021

AbstractIn the chemical industry large amounts of saline wastewater occur. Its disposal into rivers is a considerable burden to the ecosystem. To strive for a circular economy and enable a viable raw material recycling, energy‐efficient concentration processes are requisite. High‐pressure reverse osmosis meets this criterion, but its industrial application demands suitable membrane elements that withstand the exceptional operation conditions and provide sufficient performance. Hence, new requirements regarding the design of spiral‐wound elements arise. To identify those, specific performance‐limiting effects need a better understanding.
Effects of Postoperative Day and NR1I2 on Tacrolimus Clearance in Chinese Liver Transplant Recipients—A Population Model Approach
Authors: Lu Yanxia , Xu Li , Cui Jianrong , Shen Su , Li Xingang 
Published: June 2021

AbstractWe aimed to explore the new biomarkers influencing tacrolimus in vivo behavior in Chinese liver transplant recipients. A total of 418 drug concentration samples of 41 liver transplant patients were collected for modeling. A population pharmacokinetic model was developed using the nonlinear mixed‐effects modeling approach. The potential covariates, such as postoperative day (POD), age, body weight, hepatic and renal function, and recipient genetic polymorphisms (ABCB1, CYP3A4, CYP3A5, NR1I2) were evaluated using forward‐inclusion and backward‐elimination methods. A 1‐compartment model was used describing the in vivo behavior of tacrolimus in liver transplant patients. The estimates of CL/F and V/F were 8.88 L/h and 495.82 L, respectively. Two covariates, POD and NR1I2 rs2276707 genotypes, were incorporated into the final population pharmacokinetic model, and they could significantly impact the CL/F: CL/F (L/h) = 8.88 × (POD/16)0.18 × e0.91 × NR1I2 × eηCL. The model evaluation and validation indicated a stable and precise performance of the final model. The functional annotation using ENCODE data indicated that rs2276707 was located on the higher peak of the H3K4Me1 and H3K4Me3 histone marker. To our knowledge, this is the first report indicating NR1I2 rs2276707 genotypes is another biomarker impacting tacrolimus clearance in liver transplant recipients. The NR1I2 gene polymorphism may affect the in vivo behavior of tacrolimus by regulating gene expression.
Computational Screening of 3 d Transition Metal Atoms Anchored on Defective Graphene for Efficient Electrocatalytic N2 Fixation
Authors: Song Wei , Xie Kun , Guo Yongliang , Fu Ling , He Chaozheng 
Published: June 2021

AbstractThe synthesis of ammonia (NH3) through the electrochemical reduction of molecular nitrogen (N2) is a promising strategy for significantly reducing energy consumption compared to traditional industrial processes. Herein, we report the design of a series of monovacancy and divacancy defective graphenes decorated with single 3d transition metal atoms (TM@MVG and TM@DVG; TM=Sc−Zn) as electrocatalysts for the nitrogen‐reduction reaction (NRR) aided by density functional theory (DFT) calculations. By comparing energies for N2 adsorption as well as the free energies associated with *N2 activation and *N2H formation, we successfully identified V@MVG, with the lowest potential of −0.63 V, to be an effective catalytic substrate for the NRR in an enzymatic mechanism. Electronic properties, including Bader charges, charge density differences, partial densities of states, and crystal orbital Hamilton populations, are further analyzed in detail. We believe that these results help to explain recent observations in this field and provide guidance for the exploration of efficient electrocatalysts for the NRR.
Early maladaptive schemas and depression in adulthood: A systematic review and meta‐analysis
Authors: Bishop Amy , Younan Rita , Low Jennifer , Pilkington Pamela D. 
Published: June 2021

AbstractBackgroundImproved understanding of the specific cognitive risk factors associated with depression is needed to inform prevention and treatment approaches. Recent research has examined the relationship between early maladaptive schemas (EMSs) and depression, but the findings were yet to be integrated using meta‐analytic methods. The aim of this review was to synthesize the evidence on the relationship between depression and EMS.MethodA systematic review and meta‐analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) statement, by searching the PsycINFO, PubMed and CINAHL databases. Included studies were peer‐reviewed journal articles that examined the relationship between one or more EMS and depression in adulthood in participants aged 18 years or older.ResultsA total of 51 studies were included (k = 743; pooled N = 17,830). All 18 EMSs were positively correlated with depression, with effect sizes ranging from small (r = .23 [.17, .29]; Entitlement) to large (r = .53 [.46, .60]; Social Isolation; r = .50, 95% CI [.45, .54]; Defectiveness/Shame).ConclusionThe evidence suggests that individuals who feel like they do not belong, or that they are flawed, bad or unlovable, report higher levels of depression. However, most studies used cross‐sectional designs, and further longitudinal research is needed to establish the direction of the relationship between EMS and depression. These findings can guide preventative and treatment approaches. Focusing treatment on the Social Isolation and Defectiveness/Shame EMS may aid in relieving depressive symptoms.
Resubstitution method for big size Boolean logic design targeting look‐up‐table implementation
Authors: Lemberski Igor , Suponenkovs Artjoms 
Published: June 2021

AbstractA scalable design method to perform multilevel network minimization targeting k‐input look‐up‐tables (k‐LUT) is proposed. It contributes toward the big size logic design theory and application. The method is based on the resubstitution which is formulated and solved as a covering task: A node function, which depends on an input selected for the resubstitution, is split into a set of dichotomies. The selected input is removed, and the minimal set of inputs to cover the dichotomies are sought. The resubstitution procedure runs on top of the k‐LUT network produced by existing synthesis tools (SIS, ABC). Scalability is achieved by the extraction of windows, which satisfy given constraints (number of inputs, nodes, etc.). The window logic is described using the proposed extended programmable logic array (PLA) table, which contains information about don't cares. Experiments show that the best networks obtained using SIS and ABC can be further improved by applying our method. Also, big benchmarks from the EPFL library are processed, and for almost half of them, improvements are achieved.
IL‐33/ST2 axis deficiency exacerbates neutrophil‐dominant allergic airway inflammation
Authors: Ma Qiyun , Qian Yan , Jiang Jingxian , Wu Jingjing , Song Meijuan , Li Xinyu , Chen Zhongqi , Wang Zhengxia , Zhu Ranran , Sun Zhixiao , Huang Mao , Ji Ningfei , Zhang Mingshun 
Published: June 2021

AbstractObjectiveThe IL‐33/ST2 axis has been extensively investigated in type 2 eosinophilic inflammation. Here, we aimed to investigate the role of the IL‐33/ST2 axis in neutrophil‐dominant allergic airway inflammation.MethodsHouse‐dust mite (HDM) extract and lipopolysaccharide (LPS) were administered to establish a murine model of neutrophil‐dominant allergic airway inflammation. The formation of neutrophilic extracellular traps (NETs) in the lung tissues was demonstrated by immunofluorescence imaging. Mature IL‐33 in bronchoalveolar lavage fluid (BALF) was detected by Western blotting. The neutrophilic chemokine KC produced by bone marrow‐derived macrophages (BMDMs) or primary alveolar epithelial cells was measured with a commercial ELISA kit.ResultsIn the present study, we observed neutrophilic inflammation and tight junction damage in the lungs of mice sensitised with HDM and LPS. Furthermore, sensitisation with HDM and LPS resulted in the formation of NETs, accompanied by increased levels of mature IL‐33 in the BALF. Moreover, LPS damaged the epithelial tight junction protein occludin directly or indirectly by inducing NET formation. Surprisingly, IL‐33 deficiency augmented neutrophilia and epithelial barrier injury in the lungs of mice after sensitisation with HDM and LPS. Similarly, the absence of ST2 exacerbated the neutrophilic inflammatory response, decreased the expression of occludin and exacerbated the severity of neutrophil‐dominant allergic airway inflammation in an HDM/LPS‐induced mouse model. Mechanistically, BMDMs and alveolar epithelial cells from IL‐33‐ or ST2‐deficient mice tended to produce higher levels of the neutrophilic chemokine KC.ConclusionsThese results demonstrated that the IL‐33/ST2 axis may play a protective role in neutrophil‐dominant allergic airway inflammation.
Productivity, niche availability, species richness, and extinction risk: Untangling relationships using individual‐based simulations
Authors: Furness Euan N. , Garwood Russell J. , Mannion Philip D. , Sutton Mark D. 
Published: June 2021

AbstractIt has often been suggested that the productivity of an ecosystem affects the number of species that it can support. Despite decades of study, the nature, extent, and underlying mechanisms of this relationship are unclear. One suggested mechanism is the “more individuals” hypothesis (MIH). This proposes that productivity controls the number of individuals in the ecosystem, and that more individuals can be divided into a greater number of species before their population size is sufficiently small for each to be at substantial risk of extinction. Here, we test this hypothesis using REvoSim: an individual‐based eco‐evolutionary system that simulates the evolution and speciation of populations over geological time, allowing phenomena occurring over timescales that cannot be easily observed in the real world to be evaluated. The individual‐based nature of this system allows us to remove assumptions about the nature of speciation and extinction that previous models have had to make. Many of the predictions of the MIH are supported in our simulations: Rare species are more likely to undergo extinction than common species, and species richness scales with productivity. However, we also find support for relationships that contradict the predictions of the strict MIH: species population size scales with productivity, and species extinction risk is better predicted by relative than absolute species population size, apparently due to increased competition when total community abundance is higher. Furthermore, we show that the scaling of species richness with productivity depends upon the ability of species to partition niche space. Consequently, we suggest that the MIH is applicable only to ecosystems in which niche partitioning has not been halted by species saturation. Some hypotheses regarding patterns of biodiversity implicitly or explicitly overlook niche theory in favor of neutral explanations, as has historically been the case with the MIH. Our simulations demonstrate that niche theory exerts a control on the applicability of the MIH and thus needs to be accounted for in macroecology.
IL‐33/ST2 as a potential target for tumor immunotherapy
Authors: Jiang Wenyi , Lian Jingyao , Yue Ying , Zhang Yi 
Published: June 2021

AbstractIL‐33, a member of the IL‐1 family, was initially reported to be expressed constitutively in the nucleus of tissue‐lining and structural cells. However, upon tissue damage or injury, IL‐33 can be released quickly to bind with its cognate receptor ST2 in response to wound healing and inflammation and act as a DAMP. As a key regulator of Th2 responses, IL‐33/ST2 signal is primarily associated with immunity and immune‐related disorders. In recent years, IL‐33/ST2 signaling pathway has been reported to promote the development of cancer and remodel the tumor microenvironment by expanding immune suppressive cells such as myeloid‐derived suppressor cells or regulatory T cells. However, its role remains controversial in some tumor settings. IL‐33 could also promote effective infiltration of immune cells such as CD8+ T and NK cells, which act as antitumor. These dual effects may limit the clinical application to target this cytokine axis. Therefore, more comprehensive exploration and deeper understanding of IL‐33 are required. In this review, we summarized the IL‐33/ST2 axis versatile roles in the tumor microenvironment with a focus on the IL‐33‐target immune cells and downstream signaling pathways. We also discuss how the IL‐33/ST2 axis could be used as a potential therapeutic target for cancer immunotherapy.
TNFAIP3 Interacting Protein 3 Is an Activator of Hippo‐YAP Signaling Protecting Against Hepatic Ischemia/Reperfusion Injury
Authors: Zhou Junjie , Hu Manli , He Meiling , Wang Xiaoming , Sun Dating , Huang Yongping , Cheng Xu , Fu Jiajun , Cai Jie , Ma Tengfei , Tian Song , Hu Yufeng , Hu Fengjiao , Liu Dan , He Yanqi , Yan Lanlan , She Zhi‐Gang , Zhang Xiao‐Jing , Ji Yan‐Xiao , Liu Hui , Li Hongliang , Yang Hailong , Zhang Peng 
Published: June 2021

Background and Aims
Hepatic ischemia/reperfusion (I/R) injury, a common clinical problem that occurs during liver surgical procedures, causes a large proportion of early graft failure and organ rejection cases. The identification of key regulators of hepatic I/R injury may provide potential strategies to clinically improve the prognosis of liver surgery. Here, we aimed to identify the role of tumor necrosis factor alpha‐induced protein 3–interacting protein 3 (TNIP3) in hepatic I/R injury and further reveal its immanent mechanisms.

Approach and Results
In the present study, we found that hepatocyte TNIP3 was markedly up‐regulated in livers of both persons and mice subjected to I/R surgery. Hepatocyte‐specific Tnip3 overexpression effectively attenuated I/R‐induced liver necrosis and inflammation, but improved cell proliferation in mice, whereas TNIP3 ablation largely aggravated liver injury. This inhibitory effect of TNIP3 on hepatic I/R injury was found to be dependent on significant activation of the Hippo‐YAP signaling pathway. Mechanistically, TNIP3 was found to directly interact with large tumor suppressor 2 (LATS2) and promote neuronal precursor cell‐expressed developmentally down‐regulated 4–mediated LATS2 ubiquitination, leading to decreased Yes‐associated protein (YAP) phosphorylation at serine 112 and the activated transcription of factors downstream of YAP. Notably, adeno‐associated virus delivered TNIP3 expression in the liver substantially blocked I/R injury in mice.

Conclusions
TNIP3 is a regulator of hepatic I/R injury that alleviates cell death and inflammation by assisting ubiquitination and degradation of LATS2 and the resultant YAP activation.TNIP3 represents a promising therapeutic target for hepatic I/R injury to improve the prognosis of liver surgery.
Some implications of postnatal hippocampal development
Authors: Nadel Lynn 
Published: June 2021

AbstractIt is well established that in most species, the hippocampus shows extensive postnatal development. This delayed maturation has a number of implications, which can be thought of in three categories. First, the late maturation has the direct effect of depriving the developing organism of at least some of the functions of the hippocampus, in particular place learning, context coding and in humans, episodic memory. Second, such learning that does occur very early in life, prior to hippocampal maturation, will largely bear the imprint and properties of those brain systems that, unlike the hippocampus, are fully functional early in life. Third, the active state of development of hippocampus in the first weeks and months of life render this structure susceptible to disruption by environmental and/or chromosomal factors. In this article, I discuss my efforts, with many colleagues over the past 40 years, to understand each of these implications.