bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is chemoimmunotherapy a game changer in the treatment of locally advanced head and neck squamous cell carcinoma?
Authors: Masuda Muneyuki , Nagata Ryozaburo , Hara Hirotaka , Kuroki Keiji , Sato Kuniaki , Rikimaru Fumihide , Toh Satoshi , Higaki Yuichiro 
Published: September 2021

AbstractPembrolizumab and chemotherapy (chemoimmunotherapy) were administered to 2 head and neck squamous cell carcinoma (HNSCC) patients with extremely advanced local tumors and distant metastases with palliative intent. However, they demonstrated strikingly good responses and achieved remission. Expanded application of induction chemoimmunotherapy may be useful for locally advanced HNSCC.
Acute bilateral loss of vision as organic manifestation of repressed psychological stress: A case report
Authors: Jamaluddin Ruzita , Izham Ammar Azhar , Abdul Hamid Ahmad Fadzil , Amir Hamzah Wan Nadiah , Abd Hamid Muhamad Ruzaini 
Published: September 2021

AbstractComprehensive clinical assessment with integrated team approach is crucial in managing cases of non‐organic visual loss. Apart from pharmacotherapy, psychosocial rehabilitation should also be adequately addressed.
Safe use of a once‐a‐week glucagon‐like peptide‐1 receptor agonist in a 16‐year‐old girl with type 2 diabetes when approved therapy options fail
Authors: van den Boom Louisa , Stuecher Theresa , Mader Julia K. 
Published: September 2021

AbstractThis case report demonstrates that using a non‐approved long‐acting GLP‐1‐RA (dulaglutide) in adolescents with T2D is possible and feasible under special circumstances when approved therapeutic options for the pediatric population fail to achieve adequate glycemic control.
Migration of Hem‐o‐lok clip into the common hepatic duct after laparoscopic bile duct exploration: A case report
Authors: Tan Zhenhua , Wan Renrui , Qian Hai , Xie Ping 
Published: September 2021

AbstractHem‐o‐lok clip migration into the bile duct can lead to stone formation and granulation tissue hyperplasia. This report discusses a case wherein four clips migrated into the bile duct after laparoscopic bile duct exploration.
18F‐sodium fluoride positron emission tomography may help diagnose nondisplaced peri‐prosthetic and peri‐implant fracture
Authors: Yasue Kensuke , Tokimura Fumiaki , Miyazaki Tsuyoshi 
Published: September 2021

AbstractOccult fractures are challenging to diagnose, especially those involving an implant surrounding the suspected fracture site. This is the first case wherein 18F‐sodium fluoride positron emission tomography substantially helped to diagnose peri‐prosthetic and peri‐implant fractures. The application of this imaging modality warrants further study.
Activity Test and Mechanism Study of 3DOM Ce0.8M0.1Zr0.1O2 (M=Cr, Sn, Fe, Co, Ni, Mn, Cu) Catalyst in the Selective Catalytic Reduction of NO by CO**
Authors: Liu Xia , Liu Hao , Li Danyang , Ning Gangjie , Li Xinxin , Dong Lihui , Li Bin 
Published: September 2021

AbstractA series of three‐dimensionally ordered macroporous (3DOM) Ce0.8M0.1Zr0.1O2(M=Cr, Sn, Fe, Co, Ni, Mn, Cu) catalysts are synthesized and used in CO selective catalytic reduction of NOx. The results show that the NO conversion rate of 3DOM Ce0.8Cu0.1Zr0.1O2 catalyst at a lower temperature (150 °C) is close to 60 %. Besides, 3DOM Ce0.8Cu0.1Zr0.1O2 kept a stable NO removal efficiency within a wide range of gas hourly space velocity (GHSV) and long reaction time and exhibited remarkable resistance to H2O and SO2 poisoning, both individually and simultaneously. At the same time, the formation of the 3DOM structure not only improves the reduction performance and surface active sites of the catalyst, but also forms more oxygen defects and Ce3+ in the catalyst due to the strong synergistic effect of metal ions and ceria, which improves the surface oxygen concentration of the composite oxide catalyst and further improves the catalytic activity. In addition, the doping of copper ions on the surface of the 3DOM Cu‐CZ catalyst can improve the activity of the catalyst and it can get trapped by CO to form Cu+‐CO, which plays an important role in the NO+CO reaction at low temperature. The existence of oxygen vacancy at high temperature is beneficial to the activation of O2 and the dissociation of NO in the process of CO oxidation. The reaction of NO+CO over 3DOM Cu‐CZ catalyst follows L−H and E−R mechanism respectively.
Interface Engineering in CoP/CePO4 Derived from a Prussian Blue Analogue as a Highly Efficient Electrocatalyst for Alkaline Hydrogen Evolution Reaction
Authors: Wang Zi‐Hao , Niu Zan‐Yao , Meng Yu‐Lan , Wang Xiao‐Feng , Zhu Wenyu , Zhang Nan , Song Xue‐Zhi , Tan Zhenquan 
Published: September 2021

AbstractIn this work, engineering a heterostructural interface into a CoP/CePO4 hybrid has been achieved from a pre‐designed Co‐PBA/CePO4 precursor. The new CePO4 engaged interface can regulate the electronic structure of the active CoP as well as enhance the intrinsic activity. As a result, the porous CoP/CePO4 material shows a superior electrocatalytic performance toward hydrogen evolution reaction (HER) with a lower overpotential of 162 mV to reach a current density of 10 mA cm−2 and a low Tafel slope of 48.7 mV dec−1. This research could widen the way of engineering heterostructural interfaces with a facile method and promote the exploration of MOF‐derived heterostructural electrocatalysts.
Isocyanoethyl Methacrylate (IMA) as a Bifunctional Electrolyte Additive for LiNi0.8Co0.1Mn0.1O2/Graphite Batteries with Enhanced Performance
Authors: Lu Jing , Li Shuai , Jiang Liqin , Yang Tianxiang , Fan Weizhen , Wang Wenlian , Zhao Xiaoyang , Zuo Xiaoxi , Nan Junmin 
Published: September 2021

AbstractBy now, as the promising high‐energy cathode materials of lithium‐ion batteries (LIBs), the high‐nickel LiNi0.8Co0.1Mn0.1O2 (NCM811) still have technical problems such as poor electrode‐electrolyte interface stability and sensitivity to H2O and HF in the electrolyte to be solved. In this work, isocyanoethyl methacrylate (IMA) containing −N=C=O group is developed as a bifunctional electrolyte additive through the film‐forming, H2O removal, and HF reduction to modify the electrode‐electrolyte interfaces and improve the performance of NCM811/graphite LIBs. After 450 cycles under the normal voltage range of 2.75 to 4.20 V, the capacity retention of the battery with 0.5 wt.% IMA additive increases from 50.7 % to 78.0 % compared to the battery without the additive. And under the high voltage range of 2.75 to 4.40 V, the capacity retention of the battery with IMA increases from 62.8 % to 81.9 % after 150 cycles. It is demonstrated that the IMA additive as the H2O and HF scavenger of electrolyte also facilitate the electrochemical oxidation‐reduction reactions on two electrodes to form high‐quality interfacial films, which stabilizes the anode and cathode interfaces and subsequently improves the cycling performance of the batteries. These results show that the electrolyte with IMA additive has promising prospects in the application of high‐nickel NCM‐based LIBs and provide the idea to evaluate the organic molecules containing −N=C=O group as the functional electrolyte additives as well.
Use of Self‐Assembled Monolayers for the Sequential and Independent Immobilisation of Enzymes
Authors: Serleti Alessandro , Xiao Xinxin , Shortall Kim , Magner Edmond 
Published: September 2021

AbstractThe precise spatial control of the immobilisation of enzymes is necessary for the sequential localisation of an enzymatic cascade. In this contribution, the sequential immobilisation of alcohol dehydrogenase (ADH), formaldehyde dehydrogenase (FLDH) and formate dehydrogenase (FoDH) on self‐assembled monolayer modified electrodes has been demonstrated. A range of thiols were screened and optimal enzymatic activity was obtained with thiols bearing ‐OH, a positively charged heterocyclic aromatic ring and ‐COOH for the immobilisation of ADH, FLDH and FoDH, respectively. Scanning of the applied potential was utilised to separately modify individual electrodes with the appropriate thiol and enzyme to deliver a three‐enzyme system with catalytically active enzyme. Immobilised ADH, FLDH and FoDH retained 46, 32 and 76 % of initial activity, respectively, on storage in aqueous solution at 4 °C for a period of two weeks.
Stereoselective Direct N‐Trifluoropropenylation of Heterocycles with a Hypervalent Iodonium Reagent
Authors: Csenki János T. , Mészáros Ádám , Gonda Zsombor , Novák Zoltán 
Published: September 2021

AbstractThe availability and synthesis of fluorinated enamine derivatives such as N‐(3,3,3‐trifluoropropenyl)heterocycles are challenging, especially through direct functionalization of the heterocyclic scaffold. Herein, a stereoselective N‐trifluoropropenylation method based on the use of a bench‐stable trifluoropropenyl iodonium salt is described. This reagent enables the straightforward trifluoropropenylation of various N‐heterocycles under mild reaction conditions, providing trifluoromethyl enamine type moieties with high stereoselectivity and efficiency.
Pan‐cancer analysis reveals the oncogenic role of 3‐hydroxy‐3‐methylglutaryl‐CoA synthase 1
Authors: Zhou Cheng , Wang Zhiqin , Cao Yueqing , Zhao Liang 
Published: September 2021

AbstractBackgroundEmerging studies reveals that 3‐hydroxy‐3‐methylglutaryl‐CoA synthase 1 (HMGCS1) plays vital oncogenic roles in a broad spectrum of human cancers, but there is no pan‐cancer evidence on the relationship between HMGCS1 and various tumor types.AimTo explore the potential role of HMGCS1 across various tumor types based on big clinical data.MethodsWe conducted a pan‐cancer analysis across more than 30 tumor types, based on the most comprehensive database available, including TCGA, GSCA, clinical proteomic tumor analysis consortium, Kaplan–Meier Plotter dataset, GEPIA2, TIMER2, STRING, and GDSC dataset.ResultsHMGCS1 was highly expressed and negatively correlated with the prognosis in most cancer types. The infiltration levels of cancer associated fibroblast and CD8+ T‐cell were closely associated with HMGCS1 expression. Amplification was the most common genetic alteration of HMGCS1 in different cancers, while the frequency of mutation was low. Besides, ACAT2 and MVD were closely correlated and bind to HMGCS1. Pathway enrichment analysis indicated that HMGCS1 was actively involved in steroid biosynthesis. Moreover, high HMGCS1 expression could reduce the sensitivity to most drugs in the GDSC dataset.ConclusionsOur study revealed the potential oncogenic role of HMGCS1 in cancers.
Stylized image resolution enhancement scheme based on an improved convolutional neural network in cyber‐physical systems
Authors: Liu Xiaozhu , Li Bang 
Published: September 2021

AbstractEdge computing based on intelligent techniques provides powerful processing abilities in cyber‐physical systems (CPS), thereby enabling real‐time insights, and analyses for applications. To decrease network redundancy and improve the speed of convolutional neural networks (CNNs) when performing high‐resolution stylization in image style transfer tasks, a resolution enhancement scheme is proposed based on an improved CNN in CPS. A style transfer network (RESTN) model and a two‐stage neural network training method are presented. In the first stage, the resolution enhancement ability of RESTN is trained with high‐resolution and low‐resolution image pairs, and in the second stage, the style transfer ability of RESTN is supplemented. The parameters of the feature extraction phase are shared for learning different styles, and the octave convolution operation is adopted to reduce network redundancy. Experimental results show that compared with the traditional model‐based iterative method, the proposed RESTN model can conduct training three times faster and with half of the memory cost.
An “Onion‐like” Model of Protein Unfolding: Collective versus Site Specific Approaches
Authors: Politou Anastasia S. , Pastore Annalisa , Temussi Piero Andrea 
Published: September 2021

AbstractApproximating protein unfolding by an all‐or‐none cooperative event is a convenient assumption that can provide precious global information on protein stability. It is however quickly emerging that the scenario is far more complex and that global denaturation curves often hide a rich heterogeneity of states that are largely probe dependent. In this review, we revisit the importance of gaining site‐specific information on the unfolding process. We focus on nuclear magnetic resonance, as this is the main technique able to provide site‐specific information. We review historical and most modern approaches that have allowed an appreciable advancement of the field of protein folding. We also demonstrate how unfolding is a reporter dependent event, suggesting the outmost importance of selecting the reporter carefully.
Spacer‐Dependent Cooperativity of Helicity in Fluorescent Bishelical Foldamers Based on L‐Shaped Dibenzopyrrolo[1,2‐a][1,8]naphthyridine
Authors: Matsumura Kotaro , Tateno Kotaro , Tsuchido Yoshitaka , Kawai Hidetoshi 
Published: September 2021

AbstractFor the construction of helical foldamers composed of π‐frameworks, the choice of appropriate π‐π stacking units and π‐spacers connecting them is important. The transfer of helicity between the minimal helix structural units is also an essential factor in the construction of homochiral helical foldamers. Tetramers 4 a–4 d, which have four L‐shaped dibenzopyrrolo[1,2‐a]naphthyridine units, were synthesized to investigate the interplay and cooperativity of the helical structures. Tetramer 4 a bridged with a biphenyl unit formed a homochiral bishelical structure with π–π stacking between the L‐shaped units (3.3 Å), consisting only of (P,P)‐ and (M,M)‐enantiomers without the (P,M)‐diastereomer, owing to interplay through the axial chirality of biphenyl unit in the solid state. Similarly, in solution, thermodynamic stabilization of the two helix formations worked cooperatively to favor the bishelical form of 4 a. Furthermore, bishelical foldamer 4 a emitted intense fluorescence (Φ=0.86).
Adoption of integrated reporting and changes to internal mechanisms in Japanese companies
Authors: Hosoda Masahiro 
Published: September 2021

AbstractThe increase in companies' use of integrated reporting (IR) has led to an increase in academic interest in IR. However, IR research from an internal corporate perspective is limited. This study investigates the approaches and internal mechanisms that early adopters use to implement IR. Further, the study examines whether IR drives organisational change at an early stage. A multiple case study was conducted. Data were collected through semi‐structured interviews and email exchanges with the managers responsible for IR in seven Japanese companies. Results showed that the long‐term perspective in Japanese companies might explain the application of IR without negative responses to its introduction, regardless of the approach used to adopt IR. As a first‐order change, the adoption of IR leads to incremental changes in the reporting contents and processes and linkage between financial and non‐financial measures in business strategy. The first‐order change could accelerate the promotion and practice of integrated thinking, thus leading to second‐order changes. However, awareness of integrated thinking needs to be raised not only in management but also in lower levels of the organisation. The use of IR within companies is one possible solution to this problem. This study contributes to new knowledge regarding sustainability and sustainability reporting by focusing on how the application of IR and integrated thinking can promote changes to internal mechanisms and organisational value towards the creation of long‐term value.
Local fluid shear stress operates a molecular switch to drive fetal semilunar valve extension
Authors: Pham Duc H. , Dai Charles R. , Lin Belle Y. , Butcher Jonathan T. 
Published: September 2021

AbstractBackgroundWhile much is known about the genetic regulation of early valvular morphogenesis, mechanisms governing fetal valvular growth and remodeling remain unclear. Hemodynamic forces strongly influence morphogenesis, but it is unknown whether or how they interact with valvulogenic signaling programs. Side‐specific activity of valvulogenic programs motivates the hypothesis that shear stress pattern‐specific endocardial signaling controls the elongation of leaflets.ResultsWe determined that extension of the semilunar valve occurs via fibrosa sided endocardial proliferation. Low OSS was necessary and sufficient to induce canonical Wnt/β‐catenin activation in fetal valve endothelium, which in turn drives BMP receptor/ligand expression, and pSmad1/5 activity essential for endocardial proliferation. In contrast, ventricularis endocardial cells expressed active Notch1 but minimal pSmad1/5. Endocardial monolayers exposed to LSS attenuate Wnt signaling in a Notch1 dependent manner.ConclusionsLow OSS is transduced by endocardial cells into canonical Wnt signaling programs that regulate BMP signaling and endocardial proliferation. In contrast, high LSS induces Notch signaling in endocardial cells, inhibiting Wnt signaling and thereby restricting growth on the ventricular surface. Our results identify a novel mechanically regulated molecular switch, whereby fluid shear stress drives the growth of valve endothelium, orchestrating the extension of the valve in the direction of blood flow.
Positive impacts of livestock and wild ungulate routes on functioning of dryland ecosystems
Authors: Stavi Ilan , Yizhaq Hezi , Osem Yagil , Argaman Eli 
Published: September 2021

AbstractLivestock grazing is often perceived as being detrimental to the quality and functioning of dryland ecosystems. For example, a study in a semiarid Kenyan savanna proposed that cattle form bare spaces throughout the landscape, which indicate ecosystem degradation. Other studies, conducted in north‐eastern Spain, where climatic conditions range between semiarid and Mediterranean subhumid, reported that sheep and goat trails have increased the emergence of rill erosion processes. Sometimes, this negative perception is extended to include wild, large ungulate herbivores as well. Here, we challenge this perception by highlighting the generally nonadverse and even ameliorative impacts of moderate animal rate on geoecosystem functioning of hilly drylands. Specifically, trampling routes (also known as treading paths, livestock terracettes, cattle trails, migration tracks, cowtours, etc.) formed across hillslopes by grazing animals—being either domesticated livestock or native large herbivores—transform the original two‐phase vegetation mosaic of shrubby patches and interpatch spaces into a three‐phase mosaic. The animal routes increase the complexity of ecosystem, by strengthening the spatial redistribution of water and soil resources at the patch scale and decreasing hydrological connectivity at the hillslope scale. As a consequence, the animal routes improve functioning of hilly drylands and increase their resilience to long‐term droughts and climatic change. Therefore, instead of viewing the animal routes as degraded spots, they should be perceived at a wider perspective that allows to properly understand their overall role in sustaining dryland geoecosystems.
Deciphering the rarity–detectability continuum: optimizing survey design for terrestrial mammalian community
Authors: Chatterjee Nilanjan , Schuttler Stephanie G. , Nigam Parag , Habib Bilal 
Published: September 2021

AbstractWildlife monitoring is of fundamental importance to establish baseline information, measure population changes, and extinction risk. Motion‐triggered camera traps are an increasingly popular tool for monitoring terrestrial species over large landscapes. Over the years, occupancy has become a robust and unbiased state variable to monitor species worldwide. However, the optimal sampling design required for robust estimations of occupancy is lacking for many species. Here, we estimated the optimum sampling design by varying the number of sites (50–400) and sampling days (10–25) for a range of mammal species using camera‐trap survey data from central India. We used power analysis and mean‐squared error and evaluated the hypothesis of how various species‐specific traits influence occupancy and detectability of the species. We found that mean‐squared error changed significantly with the number of sampling sites for rare species, whereas for species with moderate and high detection probability, the mean‐squared error changed significantly with the number of sampling occasions. Power increased with an increase in the number of sampling sites and occasions for all species, although the change was not significant for species with higher occupancies or detection probabilities. We found that body size was positively related to occupancy but did not influence detection probability significantly. No relationship was detected with social status or diet on occupancy or detection probability. Our results suggest a minimum of 50 sites for 15–20 d for common species and 100 sites for 20–30 d for rare, elusive species. Our results provide guidelines to managers and practitioners for effective allocation of cost and sampling effort for a wide variety of terrestrial mammals in camera‐trap surveys.
Design of a multifaceted strategy based on automated text messaging in patients with recent heart failure admission
Authors: Rohde Luis E. , Hoffmann Filho Conrado R. , Rover Marciane M. , Rabelo‐Silva Eneida Rejane , Lopez Letícia , Passos Luiz C.S. , Silvestre Odilson M. , Martins Silvia M. , de Figueiredo Neto José A. , Silveira Fábio S. , Canesin Manoel F. , Simões Marcus V. , Akio Nishijuka Fábio , Bertoldi Eduardo G. , Danzmann Luiz C. , Mourilhe‐Rocha Ricardo , Magedanz Ellen Hettwer , Esteves Mauro , de Castilho Fábio M. , Fernandes‐Silva Miguel M. , Ritt Luiz E.F. , Blacher Mariana , Soares Rafael M. , Cavalcanti Alexandre B. , Ramirez Felix 
Published: September 2021

AbstractAimsTo evaluate a telemonitoring strategy based on automated text messaging and telephone support after heart failure (HF) hospitalization.Methods and resultsThe MESSAGE‐HF study is a prospective multicentre, randomized, nationwide trial enrolling patients from 30 clinics in all regions of Brazil. HF patients with reduced left ventricular ejection fraction (<40%) and access to mobile phones are eligible after an acute decompensated HF hospitalization. Patients meeting eligibility criteria undergo an initial feasibility text messaging assessment and are randomized to usual care or telemonitoring intervention. All patients receive a HF booklet with basic information and recommendations about self‐care. Patients in the intervention group receive four daily short text messages (educational and feedback) during the first 30 days of the protocol to optimize self‐care; the feedback text messages from patients could trigger diuretic adjustments or a telephone call from the healthcare team. After 30 days, the frequency of text messages can be adjusted. Patients are followed up after 30, 90, and 180 days, with final status ascertained at 365 days by telephone. Our primary endpoint is the change in N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) levels after 180 days. Secondary endpoints include changes in NT‐proBNP after 30 days; health‐related quality of life, HF self‐care, and knowledge scales after 30 and 180 days; and a composite outcome of HF hospitalization and cardiovascular death, adjudicated by a blinded and independent committee.ConclusionsThe MESSAGE‐HF trial is evaluating an educational and self‐care promotion strategy involving a simple, intensive, and tailored telemonitoring system. If proven effective, it could be applied to a broader population worldwide.