bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating underlying causative factors for earthquake-induced landslides and landslide susceptibility mapping in Upper Indrawati Watershed, Nepal
Authors: Gautam Pawan , Kubota Tetsuya , Aditian Aril 
Published: December 2021

AbstractThe main objective of this study is to understand the overall impact of earthquake in upper Indrawati Watershed, located in the high mountainous region of Nepal. Hence, we have assessed the relationship between the co-seismic landslide and underlying causative factors as well as performed landslide susceptibility mapping (LSM) to identify the landslide susceptible zone in the study area. We assessed the landslides distribution in terms of density, number, and area within 85 classes of 13 causal factors including slope, aspect, elevation, formation, land cover, distance to road and river, soil type, total curvature, seismic intensity, topographic wetness index, distance to fault, and flow accumulation. The earthquake-induced landslide is clustered in Northern region of the study area, which is dominated by steep rocky slope, forested land, and low human density. Among the causal factors, 'slope' showed positive correlation for landslide occurrence. Increase in slope in the study area also escalates the landslide distribution, with highest density at 43%, landslide number at 4.34/km2, and landslide area abundance at 2.97% in a slope class (> 50°). We used logistic regression (LR) for LSM integrating with geographic information system. LR analysis depicts that land cover is the best predictor followed by slope and distance to fault with higher positive coefficient values. LSM was validated by assessing the correctly classified landslides under susceptibility categories using area under curve (AUC) and seed cell area index (SCAI). The LSM approach showed good accuracy with respective AUC values for success rate and prediction rate of 0.843 and 0.832. Similarly, the decreasing SCAI value from very low to very high susceptibility categories advise satisfactory accuracy of the LSM approach.
Glycoprotein 2 in health and disease: lifting the veil
Authors: Lin Yingsong , Nakatochi Masahiro , Sasahira Naoki , Ueno Makoto , Egawa Naoto , Adachi Yasushi , Kikuchi Shogo 
Published: December 2021

AbstractIn 2020, we discovered glycoprotein 2 (GP2) variants associated with pancreatic cancer susceptibility in a genome-wide association study involving the Japanese population. Individuals carrying a missense coding variant (rs78193826) in the GP2 gene resulting in a p.V432M substitution had an approximately 1.5-fold higher risk of developing pancreatic cancer than those without this variant. GP2 is expressed on the inner surface of zymogen granules in pancreatic acinar cells, which are responsible for the sorting, storage and secretion of digestive enzymes. Upon neuronal, hormonal, or other stimulation, GP2 is cleaved from the membrane of zymogen granules and then secreted into the pancreatic duct and intestinal lumen. While the functions of GP2 remain poorly understood, emerging evidence suggests that it plays an antibacterial role in the gastrointestinal tract after being secreted from pancreatic acinar cells. Impaired GP2 functions may facilitate the adhesion of bacteria to the intestinal mucosa. In this review article, we summarize the role of GP2 in health and disease, emphasizing its functions in the gastrointestinal tract, as well as genetic variations in the GP2 gene and their associations with disease susceptibility. We hope that its robust genetic associations with pancreatic cancer, coupled with its emerging role in gastrointestinal mucosal immunity, will spur renewed research interest in GP2, which has been understudied over the past 30 years compared with its paralog uromodulin (UMOD).
A comprehensive review of machine learning techniques on diabetes detection
Authors: Sharma Toshita , Shah Manan 
Published: December 2021

AbstractDiabetes mellitus has been an increasing concern owing to its high morbidity, and the average age of individual affected by of individual affected by this disease has now decreased to mid-twenties. Given the high prevalence, it is necessary to address with this problem effectively. Many researchers and doctors have now developed detection techniques based on artificial intelligence to better approach problems that are missed due to human errors. Data mining techniques with algorithms such as - density-based spatial clustering of applications with noise and ordering points to identify the cluster structure, the use of machine vision systems to learn data on facial images, gain better features for model training, and diagnosis via presentation of iridocyclitis for detection of the disease through iris patterns have been deployed by various practitioners. Machine learning classifiers such as support vector machines, logistic regression, and decision trees, have been comparative discussed various authors. Deep learning models such as artificial neural networks and recurrent neural networks have been considered, with primary focus on long short-term memory and convolutional neural network architectures in comparison with other machine learning models. Various parameters such as the root-mean-square error, mean absolute errors, area under curves, and graphs with varying criteria are commonly used. In this study, challenges pertaining to data inadequacy and model deployment are discussed. The future scope of such methods has also been discussed, and new methods are expected to enhance the performance of existing models, allowing them to attain greater insight into the conditions on which the prevalence of the disease depends.
Pelvic floor rehabilitation in the treatment of mixed urinary incontinence among women
Authors: Elshatby Nehad Mohamed , Imam Mohamed Hassan , Shoukry Mohamed Shafik , Hassan Marwa Mohamed , Saba Emmanuel Kamal Aziz 
Published: December 2021

Abstract
Background
Mixed urinary incontinence (MUI) is a common underreported problem among females; it has a major effect on patients’ quality of life. Treatment may be difficult since a single modality cannot be enough to alleviate both the urge and the stress symptoms. Biofeedback-assisted pelvic floor muscle training (PFMT) has a great role in strengthening the pelvic floor muscles especially when accompanied by electrical stimulation. Neuromodulation is another safe well-tolerated method that may improve symptoms of female voiding dysfunction. There are no previous studies that assessed the efficacy of biofeedback-assisted pelvic floor muscle training versus two different types of peripheral neuromodulation which are transcutaneous posterior tibial nerve stimulation (TPTNS) and anogenital neuromodulation in the treatment of mixed urinary incontinence among women. The aim of this work is to study the effectiveness of biofeedback-assisted pelvic floor muscle training with electrostimulation versus two different methods of peripheral neuromodulation techniques in the treatment of women with MUI. Patients were subjected to history taking, assessment questionnaires (Questionnaire for female Urinary Incontinence Diagnosis (QUID), Australian Pelvic Floor Questionnaire (PFQ), and International Consultation on Incontinence Questionnaire-Urinary Incontinence-Short Form (ICIQ-UI-SF)), clinical examination, and manometric pressure assessment. The patients were allocated randomly into three groups. Group I received biofeedback-assisted pelvic floor muscle training and faradic electrical stimulation, group II received posterior tibial neuromodulation, and group III received anogenital neuromodulation.

Results
The present study included 68 non-virgin female patients with mixed urinary incontinence. Significant improvement was noticed in the three studied groups on the subjective and objective levels. No statistically significant difference was reported between the studied groups following the different types of intervention.

Conclusions
Biofeedback-assisted pelvic floor muscle training with electrostimulation is as effective as anogenital neuromodulation and posterior tibial neuromodulation in the treatment of mixed urinary incontinence among females.

Trial registration
PACTR, PACTR202107816829078. Registered 29 July 2021 - Retrospectively registered.
Novel Program Offering Remote, Asynchronous Subspecialist Input in Thoracic Oncology: Early Experience and Insights Gained During the COVID-19 Pandemic
Authors: West Howard Jack , Tan Yuan Angela , Barzi Afsaneh , Wong Debra , Parsley Robert , Sachs Todd 
Published: December 2021

PURPOSE: AccessHope is a program developed initially by City of Hope to provide remote subspecialist input on cancer care for patients as a supplemental benefit for specific payers or employers. The leading platform for this work has been an asynchronous model of review of medical records followed by a detailed assessment of past and current management along with discussion of potential future options in a report sent to the local oncologist. This summary describes an early period of development and growth of this service, focusing on cases of lung cancer, particularly during the COVID-19 pandemic. METHODS: Cases were primarily identified by a trigger list of cancer diagnoses that included non–small-cell lung cancer and small-cell lung cancer. After medical records were obtained, a summary narrative was provided to a thoracic oncology specialist who wrote a case review sent to the local physician, followed by a direct discussion with the recipient. We focused on feasibility as measured by case volumes, the rates of concordance between the subspecialist reviewer with the local team, and cost savings from recommended changes, using descriptive statistics. RESULTS: From April 2019 to November 2020, 110 cases were reviewed: 55% male, median age 62.5 years (range, 33-92 years); 82% non–small-cell lung cancer (12% stage I or II, 16% stage III, and 57% stage IV), and 17% small-cell lung cancer (4% limited and 14% extensive). Median turnaround time for report send-out was 5.0 days. The review agreed with local management in 79 (72%) cases and disagreed in 31 (28%) cases; notably, specific additional recommendations were associated with evidence-based anticipated improvements in efficacy in 76 cases (69%) and improvement in potential for cure in 14 cases (13%). Recommendations leading to cost savings were identified in 14 cases (13%), translating to a projected cost savings of $19,062 (USD) per patient for the entire cohort of patient cases reviewed. CONCLUSION: We demonstrate the feasibility of completing a rapid turnaround of cases of lung cancer either patient-initiated for review or prospectively triggered by diagnosis and stage. This program of asynchronous second opinions identified evidence-based management changes affecting current treatment in 28% and potential improvements to improve care in 92% of patients, along with cost savings realized by eliminating low-value interventions.
Novel Transdural Epiarachnoid Approach for Large Central Disk Herniation in Upper Lumbar Spine
Authors: Nishikawa Hirofumi , Fujimoto Masashi , Tanioka Satoru , Ikezawa Munenari , Nakatsuka Yoshinari , Araki Tomohiro , Suzuki Hidenori , Mizuno Masaki 
Published: December 2021

BACKGROUND AND IMPORTANCE:
The treatment for large central disk herniation (LCDH) at upper lumbar spine is often challenging. Previous reports showed various surgical strategies, such as microdiscectomy with posterior fixation, endoscopic surgery, and microdiscectomy through transdural approach. However, there is no consensus regarding which surgical option is better for LCDH at upper lumbar spine. In this report, we describe the novel transdural epiarachnoid approach (TDEA), which uses the corridor of epiarachnoid space for microdiscectomy. Compared with classical transdural approaches, this novel approach may reduce risks of postoperative cerebrospinal fluid leakage and the development of arachnoiditis.

CLINICAL PRESENTATION:
A 69-yr-old man presented with progressive bilateral radiating leg pain, intermittent claudication, and low back pain. Magnetic resonance images and computed tomography scans revealed LCDH at L2/3 level. We performed microdiscectomy using the TDEA. Postoperative course was uneventful, and his symptoms were relieved after surgery.

CONCLUSION:
The novel TDEA for LCDH at upper lumbar spine is illustrated with a video. This novel approach has an advantage of the preservation of subarachnoid components compared with classical transdural approaches.
Multiple neural bHLHs ensure the precision of a neuronal specification event in Caenorhabditis elegans
Authors: Filippopoulou Konstantina , Couillault Carole , Bertrand Vincent 
Published: December 2021

ABSTRACT
Neural bHLH transcription factors play a key role in the early steps of neuronal specification in many animals. We have previously observed that the Achaete-Scute HLH-3, the Olig HLH-16 and their binding partner the E-protein HLH-2 activate the terminal differentiation program of a specific class of cholinergic neurons, AIY, in Caenorhabditis elegans. Here we identify a role for a fourth bHLH, the Neurogenin NGN-1, in this process, raising the question of why so many neural bHLHs are required for a single neuronal specification event. Using quantitative imaging we show that the combined action of different bHLHs is needed to activate the correct level of expression of the terminal selector transcription factors TTX-3 and CEH-10 that subsequently initiate and maintain the expression of a large battery of terminal differentiation genes. Surprisingly, the different bHLHs have an antagonistic effect on another target, the proapoptotic BH3-only factor EGL-1, normally not expressed in AIY and otherwise detrimental for its specification. We propose that the use of multiple neural bHLHs allows robust neuronal specification while, at the same time, preventing spurious activation of deleterious genes.
Smaug1 membrane-less organelles respond to AMPK and mTOR and affect mitochondrial function
Authors: Fernández-Alvarez Ana J. , Gabriela Thomas María , Pascual Malena L. , Habif Martín , Pimentel Jerónimo , Corbat Agustín A. , Pessoa João P. , La Spina Pablo E. , Boscaglia Lara , Plessis Anne , Carmo-Fonseca Maria , Grecco Hernán E. , Casado Marta , Boccaccio Graciela L. 
Published: December 2021

ABSTRACT
Smaug is a conserved translational regulator that binds numerous mRNAs, including nuclear transcripts that encode mitochondrial enzymes. Smaug orthologs form cytosolic membrane-less organelles (MLOs) in several organisms and cell types. We have performed single-molecule fluorescence in situ hybridization (FISH) assays that revealed that SDHB and UQCRC1 mRNAs associate with Smaug1 bodies in U2OS cells. Loss of function of Smaug1 and Smaug2 (also known as SAMD4A and SAMD4B, respectively) affected both mitochondrial respiration and morphology of the mitochondrial network. Phenotype rescue by Smaug1 transfection depends on the presence of its RNA-binding domain. Moreover, we identified specific Smaug1 domains involved in MLO formation, and found that impaired Smaug1 MLO condensation correlates with mitochondrial defects. Mitochondrial complex I inhibition upon exposure to rotenone, but not strong mitochondrial uncoupling upon exposure to CCCP, rapidly induced the dissolution of Smaug1 MLOs. Metformin and rapamycin elicited similar effects, which were blocked by pharmacological inhibition of AMP-activated protein kinase (AMPK). Finally, we found that Smaug1 MLO dissolution weakens the interaction with target mRNAs, thus enabling their release. We propose that mitochondrial respiration and the AMPK–mTOR balance controls the condensation and dissolution of Smaug1 MLOs, thus regulating nuclear mRNAs that encode key mitochondrial proteins.
This article has an associated First Person interview with the first authors of the paper.
Mechanisms Responsible for Adsorption of Molybdate ions on Alumina for the Production of Medical Radioisotopes
Authors: Fujita Yoshitaka , Niizeki Tomotake , Fukumitsu Nobuyoshi , Ariga Katsuhiko , Yamauchi Yusuke , Malgras Victor , Kaneti Yusuf Valentino , Liu Chia-Hung , Hatano Kentaro , Suematsu Hisayuki , Suzuki Tatsuya , Tsuchiya Kunihiko 
Published: December 2021

Abstract
In this work, the mechanisms responsible for the adsorption of molybdate ions on alumina are investigated using in-depth surface analyses of alumina specimens immersed in solutions containing different molybdate ions at different pH values. The obtained results reveal that when alumina is immersed in an acidic solution containing molybdate ions, the hydroxyl groups present on the surface are removed to generate positively charged sites, and molybdate ions (MoO42− or AlMo6O24H63−) are adsorbed via an electrostatic interaction. Alumina dissolves slightly in an acidic solution to form AlMo6O24H63−, which is more easily desorbed than MoO42−. Furthermore, the enhancement in the Mo adsorption or desorption property may be achieved by enriching the surface of the alumina adsorbent with many –OH groups and optimizing Mo solution to adsorb molybdate ions on alumina as MoO42− ions. These findings will assist researchers in engineering more efficient and stable alumina-based adsorbents for molybdenum adsorption used in medical radioisotope (99Mo/99mTc) generators.
Toward the Synthesis of a Belt-Shaped Cyclic π-Conjugated System Comprising para-Phenylene Framework and Amide Bridging Unit
Authors: Takagi Koji , Miyamoto Daiki , Yamaguchi Hinako , Azumaya Isao 
Published: December 2021

Abstract
Belt-shaped π-conjugated systems have been attracting more and more attention in recent years from the synthetic interest as well as their mysterious properties that linear counterparts do not have. In this paper, the stepwise condensation of 2-bromo-4-(octylamino)benzoic acid and subsequent macrocyclization was carried out to obtain a cyclic hexamer (c6mer). The palladium-catalyzed direct arylation was then performed to get the target belt-shaped molecule (b6mer) although the isolation of b6mer did not meet with success because of the contamination of structural defects. Theoretical calculation of b6mer indicated the strain energy of ca. 100.9 kcal·mol−1 and revealed the electronic transition from degenerate HOMO-1 and HOMO-2 orbitals to LUMO similar to that of parent cycloparaphenylene derivatives.
Opportunistic diagnosis of osteoporotic vertebral fractures on standard imaging performed for alternative indications
Authors: Davy Shane W. , Bergin Diane 
Published: December 2021

Osteoporotic vertebral fractures (VFs) are the most common type of osteoporotic fracture. Patients with VF are at increased risk of hip fractures or additional VFs, both of which contribute to patient morbidity and mortality. Early diagnosis of VFs is essential so patients can be prescribed appropriate medical therapy.Most patients with clinical suspicion for VF have an X-ray of the spine. Many VFs are invisible on X-ray and require further imaging. CT can provide excellent bony detail but uses high doses of ionising radiation. MRI provides excellent soft tissue detail and can distinguish old from new fractures in addition to differentiating osteoporotic VFs from other causes of back pain. Bone scans have a limited role due to poor specificity.The literature suggests that radiologists frequently miss or do not report VFs when imaging is requested for an alternative clinical indication and when there is no clinical suspicion of VF. Common examples include failure to identify VFs on lateral chest X-rays, sagittal reformats of CT thorax and abdomen, lateral localizers on MRI and scout views on CT.Failure to diagnose a VF is a missed opportunity to improve management of osteoporosis and reduce risk of further fractures. This article discusses the role of radiographs, CT, MRI and bone scintigraphy in the assessment and recognition of osteoporotic fractures. This article focuses on opportunistic diagnosis of VFs on imaging studies that are performed for other clinical indications. It does not discuss use of dual energy X-ray absorptiometry which is a specific imaging modality for osteoporosis.
Active compound test: ethanolic extract of White Oyster Mushroom (Pleurotus ostreatus) Using HPLC and LC-MS
Authors: Bhekti Rahimah Santun , Firmansyah Agung , Maharani Winni , Andriane Yuke , Santosa Dicky , Romadhona Nurul 
Published: December 2021

Background: The use of herbs as traditional medicine in Indonesia is increasing, with more than 40% of Indonesia's population utilizing them. White oyster mushroom (Pleurotus Ostreatus) is a fungus that has various therapeutic effects including antioxidant, anti-inflammatory, anti-bacterial, anti-cholesterol, and anti-cancer properties. This mushroom contains many active substances in its secondary metabolites which have pharmacological effects. The purpose of this study was to identify the active compounds in the ethanolic extract of white oyster mushroom that will form the extract profile and become the basis for drug development. Methods: The active compound test used High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography with Mass Spectrometer (LC-MS). Ethanolic extract of white oyster mushroom was processed by 70% alcohol maceration, evaporation, and thickening. Results: The results of the HPLC test showed that the ethanolic extract of white oyster mushroom contained cinnamic acid and rutin, while the LC-MS test showed the presence of p-coumaric acid, Ascorbic acid, Linoleic acid, 9-Eicosene (E), Niacinamide, Veritric acid, Syringic acid, Ergosterol. Conclusions: The active compounds that were detected in the ethanolic extract of white oyster mushroom showed that the extract had the potential for antioxidant and anti-inflammatory activity.
Empowered or powerless? Contributing factors to women's appraisal of traumatic childbirth
Authors: Baptie Grace , Januário Elena Mueller , Norman Alyson 
Published: December 2021

Background Approximately one-third of women reflect on childbirth as a traumatic experience and the way women appraise their birth experience is significant to their postnatal wellbeing. This study aimed to identify and compare experiences of childbirth for mothers who reflect on birth as a traumatic or non-traumatic event. Methods Semi-structured interviews were conducted with 14 mothers in the postpartum period who appraised their birth as either traumatic or non-traumatic. The data were analysed using thematic analysis to elicit themes and subthemes. Results Thematic analysis revealed two contrasting themes relating to whether women felt empowered or powerless during birth. Empowerment was associated with women's trust in their maternity care, the sense of control they felt over their body and birth and the extent to which they felt informed of their options. Being powerless was associated with distrust towards healthcare services, feeling as though they lacked control over the process and feeling ‘in the dark’ about what was happening. Conclusions Women's sense of empowerment during birth is an important contributor to the appraisal of childbirth as a traumatic or non-traumatic experience. Empowerment is largely determined by the dynamic between a mother and the support around her.