bluuebunny/crossref_metadata_2025_split huggingface dataset:
IN VITRO BIOLOGICAL ACTIVITY EVALUATION OF ETHANOLIC EXTRACT OF MELICA UNIFLORA LEAVES
Authors: ÇİL Elif , TÜRKİŞ Sevda , ÇOL AYVAZ Melek , BÖRÇEK KASURKA Ceren 
Published: January 2021

Melica uniflora is part of the omnivore and
herbivore animal diets and there is not enough study about this plant. The aim
of the study is to provide the antimicrobial and antioxidant potential of
ethanol extract of M. uniflora leaves.
Total phenolic and
flavonoid contents and antioxidant potential based on different methods and
antimicrobial activity of M. uniflora leaves ethanol extract were examined.
Disk diffusion method against to
eight bacteria strains, the Folin-Ciocalteu
method, DPPH free radical scavenging activity and ferric reducing
antioxidant power assays were used. Mean diameters of inhibition zones were found in the range of
14.93 mm to 26.32 mm.
The total phenolic content of ethanol extract of M. uniflora leaves was
determined as 0.466 mg GAE/g. Total antioxidant activity value of the extract was
calculated 4.54 mg AAE/g. IC50
value was calculated 18.798 mg/mL for DPPH free radical scavenging activity.
The FRAP value indicated that the reducing
power of 1 gram of sample was equivalent to 3.33 µmol of trolox. The flavonoid
content of the extract was calculated as
4.44 mgQE/g. According to the obtained results, the analyzed M.
uniflora leaves ethanol extracts demonstrated antioxidant and antimicrobial
activity level can be considered effective.
Factors Determining the Perceived Security Dimensions in B2C Electronic Commerce Website Usage: An Indonesian Study
Authors: Marianus Santos , Ali Syaiful 
Published: January 2021

Research aims: This study aims to analyze the perceived security dimensions and build a research model using perceived ease of use and perceived usefulness as variables mediating the link between perceived security and the intention to use Indonesia's B2C e-commerce websites. Design/Methodology/Approach: Using a purposive sampling approach, this study conducted an online survey of respondents who had done online transactions, such as business-to-customer (B2C) transactions. Research Findings: The study's results showed that perceived security significantly correlated with buyers' intention to use B2C websites. Theoretical contribution/Originality: This study contributes to developing and validating key dimensions of perceived security and their constructs. Mediation effect test results from TAM, which were perceived ease and perceived use, indicated that only the perceived usefulness variable significantly mediated the relationship between perceived security and intention to use B2C e-commerce websites. Perceived use's mediation was not supported. Practitioner/Policy implication: This research empirically supports the perceived security construct as a second-order construct involving confidentiality, availability, non-repudiation, and privacy. Research limitation/Implication: This study used data from Indonesian individuals, which may differ from other countries' characteristics. It may limit the research' finding generalization. Research aims: This study aims to analyze the perceived security dimensions and build a research model using perceived ease of use and perceived usefulness as variables mediating the link between perceived security and the intention to use Indonesia's B2C e-commerce websites.Design/Methodology/Approach: Using a purposive sampling approach, this study conducted an online survey of respondents who had done online transactions, such as business-to-customer (B2C) transactions.Research Findings: The study's results showed that perceived security significantly correlated with buyers' intention to use B2C websites.Theoretical contribution/Originality: This study contributes to developing and validating key dimensions of perceived security and their constructs. Mediation effect test results from TAM, which were perceived ease and perceived use, indicated that only the perceived usefulness variable significantly mediated the relationship between perceived security and intention to use B2C e-commerce websites. Perceived use's mediation was not supported.Practitioner/Policy implication: This research empirically supports the perceived security construct as a second-order construct involving confidentiality, availability, non-repudiation, and privacy.Research limitation/Implication: This study used data from Indonesian individuals, which may differ from other countries' characteristics. It may limit the research' finding generalization.
New Remuneration System for Village Government Apparatus (APD): Can it Halt Fraud Incident(s)?
Authors: Yuliastina Mellani , Hudaya Muhammad , Nor Wahyudin , Ainun Basyirah 
Published: January 2021

Research aims: Central and local governments are trying to curbing fraud involving the village government apparatus (APD) by increasing the remuneration of APD, so that they are not tempted to misuse the village fund that they manage.Design/Methodology/Approach: The purpose of this study is to see whether remuneration is the cause of fraud, the extent to which the application of new PPE remuneration has an impact on reducing the potential for fraud and who is the main actor in fraud. This research uses a qualitative approach, and case study strategy research. The research was carried out in in three villages within a district, Regency of Barito Kuala, South Kalimantan. Data were collected through several relevant informants interviewed using the open-ended questions technique.Research findings: The results of this study indicate that APD is required to be professional to carry out their duties in managing village development, but on the other hand, the compensation for workload received is not commensurate with the risks faced. However, the increase in remuneration for the APD is only happened to the village head and village secretary, while the head of affairs and head of section’s renumeration remain below regional standard pay (UMR). The main cause of fraud is in the aspect of hegemony power and governance.Theoretical contribution/ Originality: The new remuneration system is supposed to curb the potential fraud, however, it leaves new loopholes for committing fraud. The paper suggests the new renumeration system needs to be revamped, in which all APD should receive minimum pay at UMR level, Improved governance, encouraging community participation and eliminating stereotypes about power as an effort to achieve prosperity.Research limitation/Implication: This research was conducted using a qualitative approach where the results of this study cannot be generalized to a wider scope.
Analysis of Young Generations toward Stock Investment Intention: A Preliminary Study in an Emerging Market
Authors: Nugraha Bagus Aditya , Rahadi Raden Aswin 
Published: January 2021

Research aims: This study attempts to analyze the young generations' perceptive variables in Indonesia, namely millennial (generation Y) and generation Z toward stock investment intention preliminarily.Design/Methodology/Approach: This study posits perceptive variables from the Theory of Planned Behavior (TPB) with various demographic characteristics as tablemoderating variables. This study utilized a structured online questionnaire survey to collect 64 samples and being analyzed by PLS-SEM. The group differences that being examined were investigated with multi-group analysis.Research findings: The findings from this study revealed that not all perceptive variables from TPB were significant on young Indonesian generations toward stock investment intention; only attitudes toward behavior had a significant effect. These findings were contrary to prior literature. Besides, Indonesia's young generations’ education level also played a moderating role in influencing stock investment intention. Theoretical contribution/Originality: This preliminary study provides potential facts regarding the applicability of the Theory of Planned Behavior in the emerging market (Indonesia) in stock investment intention.Practitioner/Policy implication: The practical contribution would be insights for policymaker and Securities Firms regarding young generations’ perspective on stock investment and what possible actions in terms of policies, programs, and campaigns that need to be done to increase the growth of investors’ number in Indonesia. For public firms, the insights could be useful in constructing sustainability strategies in terms of funding source from the firm’s stock.Research limitation/Implication: The sample used for this preliminary study was restricted to young generations divided into generation Y and Z from Indonesia only. This study focused on the fundamental implementation of TPB only; hence, the individual behavioral intention analysis was limited to TPB proxies. Since an online survey using a questionnaire was used to collect the data, the findings were limited and depending on the respondents’ answers regarding the issue.
Make Your Cake and Eat It: Refueling of Immune Fitness in AML Post Allo-HCT Using Baking Soda
Authors: Tonks Alex 
Published: January 2021

Abstract
Although there has been a recent renaissance in the availability of new therapeutic options for patients with acute myeloid leukemia (AML), survival rates remain low coupled with a high incidence of relapse. Enhancing T cell and immune function has become an effective therapeutic approach in hematological malignancies. However, AML cells can modulate the bone marrow microenvironment by changing extracellular nutrient and biochemical availability which can metabolically regulate immune function. Here we review the findings by Uhl et al. showing that T cell metabolism and function can be boosted by treatment with sodium bicarbonate to counteract the metabolic changes induced by lactic acid produced by leukemia cells.
KOMPARASI PEMIKIRAN BERWICK SAYERS DAN MARY MORTIMER TENTANG SISTEM KLASIFIKASI PERPUSTAKAAN
Authors: Fadilla Nurul 
Published: January 2021

<p>Tulisan ini membahas bagaimana sistem klasifikasi perpustakaan yang baik dan bersumber dari hasil pemikiran Berwick Sayers dan Mary Mortimer, kemudian dilakukan komparasi serta dilihat kerelevansian atas hasil pemikiran tersebut. Tulisan ini menggunakan pendekatan kualitatif. Analisis dilakukan secara deksriptif komparatif. Berwick Sayers dan Mary Mortimer telah dikenal banyak memunculkan pemikiran-pemikiran dan menghasilkan karya-karya salah satunya tentang sistem klasifikasi perpustakaan. Dari hasil komparasi pemikiran yang telah dilakukan tentang sistem klasifikasi perpustakaan, terdapat empat hal perbedaan yang mendasar diantara kedua tokoh tersebut. Perbedaan tersebut terletak pada 1) Bentuk klasifikasi yang baik itu adalah yang mudah digunakan, pernyataan tersebut secara tegas diberikan oleh Mary Mortimer, karena baik versi pustakawan belum tentu baik versi pemustaka, sehingga akan berbeda hasilnya, namun yang mudah digunakan bagi pemustaka, sudah pasti baik bentuk klasifikasinya, sedangkan Berwick Sayers tidak memberikan pernyataan yang menegaskan namun hanya menjelaskan perihal klasifikasi yang baik, 2) Notasi yang sederhana vs notasi yang spesifik, 3) Memiliki tabel geografis, 4) Alfabetis vs sistematis. Dan didapat pula empat persamaan yaitu 1) Meliputi seluruh bidang ilmu pengetahuan, 2) Mampu mengakomodasi subjek dan notasi ilmu pengetahuan yang baru, 3) Melakukan pengembangan pada ilmu pengetahuan baru, dan 4) Mempunyai suatu badan pengawas.</p>
BEHAVIORAL ACTIVATION (BA) UNTUK MENURUNKAN GANGGUAN DEPRESI PADA MAHASISWA UNIVERSITAS NEGERI JAKARTA
Authors: Zakiah Ernita 
Published: January 2021

This study aims to examine the effect of Behavioral Activation (BA) to reduce student's depression disorders of Universitas Negeri Jakarta. Methods of data collection using observations, semi-structured interviews, and BDI measurement tools. The measuring instrument used is the Beck Depression Inventory (BDI) made by Beck in (1976) translated by Zarina (2007). Interference disorders need to be given an intervention, because subjects with depressive disorders tend to avoid social environment, easily feel tired, avoid or do nothing activities, almost all the time experiencing feelings of depression, easily distracted concentration, etc.
Psikoedukasi Pola Asuh Pada Ibu-ibu di Wilayah Puskesmas Keputih, Surabaya
Authors: Yolanda Candra Arintina  
Published: January 2021

Intervensi psikologi ini bertujuan untuk meningkatkan pengetahuan mengenai pola asuh pada ibu-ibu Posyandu Kenanga di area Puskesmas Keputih, Surabaya, dengan memberikan Psikoedukasi Pola Asuh. Subjek intervensi ini adalah 11 orang ibu yang dipilih menggunakan teknik purposive sampling. Pengetahuan mengenai pola asuh diukur menggunakan pretest-posttest kuesioner yang dibuat oleh peneliti. Hasil dari intervensi ini adalah adanya efek positif dari Psikoedukasi Pola Asuh untuk meningkatkan pemahaman pola asuh pada ibu-ibu (Asymp. Sig (2-tailed) 0.001 < 0.05).
A Virtual Reality based intervention for surgical patients: study protocol of a randomized controlled trial
Authors: Georgescu Raluca , Dobrean Anca , Silaghi Cristina Alina , Silaghi Horațiu 
Published: January 2021

Abstract
Background: Pain after surgery is normal, and treatments, including both pharmacological and psychological components, are fundamental for proper postoperative care. While several trials have investigated the analgesic effect of traditional non-pharmacological treatments, such as Cognitive Behaviors Therapies, the newer ways of delivering psychological interventions for pain after surgery are scarcely investigated. The aim of this randomized controlled trial (RCT) is to determine if delivering the psychological content through Virtual Reality (VR) along with the standard pharmacological treatment return better pain relief outcomes than standard care in adult patients following surgery. Methods: This is a protocol of a parallel RCT conducted in one community hospital. In order to test the efficacy of VR environments for reducing pain intensity, in the following day after surgery, adults (18 to 65 years) will be randomly assigned to either (1) standard treatment after surgery (control group) or (2) VR based intervention along with standard treatment. It is intended that a minimum of 30 patients be recruited in each group. For estimating the intensity of pain, both self-report and physiological measures will be used. Repeated measures of pain outcomes will be taken before and after the intervention. Moreover, for allowing an in-depth investigation of the effect of VR environments, the primary outcome will be complemented with measures of the adverse effects, level of immersion, and level of presence in the VR environment. Trial registration ClinicalTrials.gov, NCT03776344. Registered on December 14, 2018.
Factors associated with work-private life conflict and leadership qualities among line managers of health professionals in Swiss acute and rehabilitation hospitals – a cross-sectional study
Authors: Peter Karin Anne , Halfens Ruud JG , Hahn Sabine , Schols Jos MGA 
Published: January 2021

Abstract
Background: The workforce shortage of health professionals is a matter of global concern. Among possible causative factors in this shortage are the incompatibility of health professionals’ work with their private life, which may lead to increased stress and burnout symptoms, job dissatisfaction and a higher intention to leave the profession prematurely. Also, poor leadership qualities among direct line managers (e.g. clinic directors, leading physicians, ward managers, team leaders) have been associated with health professionals’ job dissatisfaction and intention to leave in previous studies. This study therefore aimed to identify key factors associated with health professionals’ work-private life conflicts and their managers’ leadership quality.Methods: The study is based on a cross-sectional survey in 26 Swiss acute and rehabilitation hospitals, consisting of 3398 health professionals from various disciplines. For data analysis, multilevel models (with hospitals as the second level variable) were performed for ‘work-private life conflict’ and ‘quality of leadership’, considering significant main effects (using AIC) and significant interactions (using BIC) of potential explanatory variables.Results: The main findings reveal that the compatibility of health professionals’ work and private life is associated with how much they can influence shift planning (possibility of exchanging shifts, B=-2.87, p<0.01), the extent to which their individual preferences are considered (e.g. working on one specific shift only, B=6.31, p<0.01), number of work shifts per weekend (B=1.38, p<0.01) and working hours per week (B=0.13, p<0.01). In addition, the factors high quantitative demands (B=0.25, p<0.01), being required to hide their emotions (B=0.16, p<0.01) and poor social community support at work (B=-0.12, p<0.01) were related to severe work-private life conflicts among health professionals. Regarding managerial leadership, health professionals perceived the leadership qualities of their direct line manager as being better if they received more social support (B=0.61, p<0.01) and rewards (B=0.41, p<0.01) at work. Conclusions: The results show key components of improving the compatibility of work and private life for health professionals as well as managerial leadership qualities, and may help leaders working in acute or rehabilitation hospitals to develop appropriate interventions.
Dimethyl sulfide acts as eat-me signal during microbial predator-prey interactions in the ocean
Authors: Shemi Adva , Alcolombri Uria , Schatz Daniella , Farstey Viviana , Rotkopf Ron , Ben-Dor Shifra , Frada Miguel , Tawfik Dan , Vardi Assaf 
Published: January 2021

Abstract
Phytoplankton are key components of the oceanic carbon and sulfur cycles 1. During bloom events, some species can emit massive amounts of the organosulfur volatile dimethyl sulfide (DMS) to the atmosphere, where it can modulate aerosol formation and affect climate. In aquatic environments, DMS plays an important role as a chemical signal mediating diverse trophic-level interactions. Yet its role in microbial predator-prey interactions remains elusive with contradicting evidence for its role in algal chemical defense and in grazer’s chemoattraction to prey cells. Here, we investigated the signaling role of DMS during zooplankton-algae interactions by genetic and biochemical manipulation of the algal DMS-generating enzyme (Dimethylsulfoniopropionate lyase, DL) from the bloom-forming alga Emiliania huxleyi. We inhibited DL activity in live E. huxleyi cells by the novel DL-inhibitor 2-bromo-3-(dimethylsulfonio)-propionate (Br-DMSP) , and overexpressed DL in the model diatom Thalassiosira pseudonana. We showed that algal DL activity did not serve as anti-grazing chemical defense, and paradoxically enhanced grazing by the model microzooplankton Oxyrrhis marina and other micro- and mesozooplankton, including ciliates and copepods. Consumption of algal prey with induced DL activity also promoted O. marina’s growth. Overall, our results demonstrate that DMS-mediated herbivory may be ecologically important and prevalent during prey-predator dynamics in oceanic ecosystems. The role of DMS as an appetizing signal to grazers revealed here raises fundamental questions regarding the retention of its biosynthetic enzyme through the evolution of dominant bloom-forming phytoplankton in the ocean.
Enhancing Reappraisal of Negative Emotional Memories With Transcranial Direct Current Stimulation
Authors: Doerig Nadja , Bohlender Rosa , Moisa Marius , Seifritz Erich , Ruff Christian , Kleim Birgit 
Published: January 2021

Abstract
Reappraisal of negative memories and experiences is central for mental health and well-being. Deficiency of reappraisal lies at the core of many psychiatric disorders and is a key target for treatment. Here we apply transcranial direct current stimulation (tDCS) to enhance reappraisal of negative emotional memories. In a randomized, sham-controlled, 2x2 between-subject and double-blinded study, we applied single sessions of anodal and sham tDCS over the right dorsolateral prefrontal cortex (DLPFC) of 101 healthy participants while reappraising a personal negative memory or engaging in a control task. We hypothesized that (i) reappraisal decreases negative valence, arousal and evaluations of the memory and leads to improved decision making, and (ii) tDCS leads to additional changes in these reappraisal outcomes. In line with these hypotheses, participants’ personal memories were rated as less negative and less arousing following reappraisal. Anodal tDCS stimulation during reappraisal was associated with significant additional reductions in negative valence compared to sham stimulation. Our results indicate that tDCS may enhance some of the effects of reappraisal. If replicated, our findings suggest potential benefits elicited by tDCS stimulation that may help to optimize current treatment approaches for psychiatric disorders.
A method for phylogenetic reconstruction of aneuploid cancers based on multiregional genotyping data
Authors: Andersson Natalie , Chattopadhyay Subhayan , Valind Anders , Karlsson Jenny , Gisselsson David 
Published: January 2021

Abstract
Phylogenetic reconstruction of cancer cell populations remains challenging. There is a particular lack of tools that deconvolve clones based on copy number aberration analyses of multiple tumor biopsies separated in time and space from the same patient. This has hampered investigations of tumors rich in aneuploidy but few point mutations, as in many childhood cancers. Here, we present DEVOLUTION, an algorithm for subclonal deconvolution followed by phylogenetic reconstruction from bulk genotyping data. It integrates copy number and sequencing information across multiple tumor regions throughout the inference process, provided that the mutated clone fraction for each mutation is known. We validate DEVOLUTION on SNP-array data from 56 pediatric tumors comprising 253 tumor biopsies confirming concordance to biological mechanisms and show a robust performance on extensive simulations of bulk genotyping data.