bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term clinical, angiographic, and optical coherence tomography findings of Mg‐based bioresorbable scaffold in patients with acute coronary syndrome
Authors: Gutiérrez‐Barrios Alejandro , Gheorghe Livia Luciana , Camacho Freire Santiago , Silva Etel , Gómez Menchero Antonio , Francisco Jose Morales Ponce , Cañadas Pruaño Dolores , Martínez Capoccioni Uriel , Gomez Lara Josep , Bretones Del Pino Teresa , Calle Perez German 
Published: February 2021

AbstractBackgroundThis study sought to evaluate the clinical outcomes of patients treated with magnesium‐based bioresorbable scaffolds (MgBRS) in the context of acute coronary syndromes (ACS) at long‐term follow‐up (24 months). The study also aims to investigate the MgBRS performance by angiography and the healing and bioresorption pattern by optical coherence tomography (OCT) at 18 months.MethodsBetween December 2016 and December 2018, a total of 90 patients admitted for ACS and treated with MgBRS (Magmaris, Biotronik AG, Bülach, Switzerland) were enrolled in a multicenter prospective study. Clinical follow‐up was performed in all patients at 24 months and angiographic and OCT follow‐up in 51.5% of patients at 18 months. Serial OCT was available in 33 patients (36.7%).ResultsAt a 2‐year follow‐up, 88.8% were free of symptoms, no cardiac death was reported, and the device‐oriented composite event (DOCE): consisting of cardiac death, target vessel myocardial infarction, and target lesion revascularization (TLR) was 13.3%. Stent thrombosis and TLR were observed in 2.2 and 11.1%, respectively. Binary restenosis was observed in 21.7% of cases and in‐stent late lumen loss was 0.61 ± 0.75 mm. By serial OCT imaging, the minimal lumen area was significantly reduced greater than 40% (from 6.12 ± 1.59 to 3.5 ± 1.55 mm2, p < .001). At follow‐up, area stenosis was 44.33 ± 23.07% and half of the patients presented indiscernible struts. The principal observed mechanism of restenosis was scaffold collapse.ConclusionsAt long‐term follow‐up, MgBRS implantation in ACS patients showed a high rate of DOCE, mainly caused by clinically driven TLR. MgBRS restenosis was caused by scaffold collapse in most of the cases.
Outcomes of transcatheter aortic valve replacement in end stage liver and renal disease
Authors: Caughron Hope , Parikh Devang , Allison Zev , Deuse Tobias , Mahadevan Vaikom S. 
Published: February 2021

AbstractObjectivesThis study evaluates in‐hospital, 30‐day, and 1‐year outcomes post‐transcatheter aortic valve replacement (TAVR) in end stage liver disease (ESLD) and/or end stage renal disease (ESRD) compared with patients without these comorbidities.BackgroundTAVR is an alternative to surgical aortic valve replacement in patients with ESLD and ESRD, though current outcomes data are limited.MethodsWe compared 309 patients (N = 29 ESLD and/or ESRD, N = 280 control) age > 18 who underwent transfemoral TAVR from 2014 to 2020 have been compared.ResultsPatients with ESLD and ESRD were younger (69.9 ± 11.7 vs. 79.1 ± 9.8, p < .01) with higher STS‐PROM scores (8.1 ± 6.7 vs. 4.6 ± 3.9, p < .01). ESRD and ESLD patients had similar rates of in‐hospital major vascular complications (3.4% vs. 3.2%, p = .96), major bleeding events (3.4% vs. 3.2%, p = .95), and mortality (0.0% vs. 1.8%, p = .47). Mortality rates were similar at 30‐days (3.4% vs. 2.1%, p = .65) with trend to higher mortality at 6‐months (6.9% vs. 3.2%, p = .31) and 1‐year (15.4% vs. 7.0%, p = .13). Readmission rates were higher in the ESLD and ESRD cohort at 6‐months (53.2% vs. 28.6%, p < .01) and 1‐year (65.4% vs. 41.0%, p = .02). One patient received dual kidney–liver transplant, 1 patient received a liver transplant, and 7 additional patients were listed for transplant.ConclusionPatients with ESLD and/or ESRD who underwent TAVR had similar mortality at discharge and 30‐days compared with patients without these comorbidities with a trend toward increased mortality at 1‐year. This study suggests that TAVR is an option for aortic valve disease patients with ESRD and/or ESLD in order to remove cardiac barriers to liver or kidney transplant.
A High‐Performance Asymmetric Supercapacitor Based on Tungsten Oxide Nanoplates and Highly Reduced Graphene Oxide Electrodes
Authors: Ashraf Muhammad , Shah Syed Shaheen , Khan Ibrahim , Aziz Md. Abdul , Ullah Nisar , Khan Mujeeb , Adil Syed Farooq , Liaqat Zainab , Usman Muhammad , Tremel Wolfgang , Tahir Muhammad Nawaz 
Published: February 2021

AbstractTungsten oxide/graphene hybrid materials are attractive semiconductors for energy‐related applications. Herein, we report an asymmetric supercapacitor (ASC, HRG//m‐WO3 ASC), fabricated from monoclinic tungsten oxide (m‐WO3) nanoplates as a negative electrode and highly reduced graphene oxide (HRG) as a positive electrode material. The supercapacitor performance of the prepared electrodes was evaluated in an aqueous electrolyte (1 m H2SO4) using three‐ and two‐electrode systems. The HRG//m‐WO3 ASC exhibits a maximum specific capacitance of 389 F g−1 at a current density of 0.5 A g−1, with an associated high energy density of 93 Wh kg−1 at a power density of 500 W kg−1 in a wide 1.6 V operating potential window. In addition, the HRG//m‐WO3 ASC displays long‐term cycling stability, maintaining 92 % of the original specific capacitance after 5000 galvanostatic charge–discharge cycles. The m‐WO3 nanoplates were prepared hydrothermally while HRG was synthesized by a modified Hummers method.
Absolute configuration of seco‐eudesmanolide inuloxin D from experimental and predicted chiroptical studies of its 4‐O‐acetyl derivative
Authors: Johnson Jordan L. , Santoro Ernesto , Zatout Roukia , Petrovic Ana G. , Cimmino Alessio , Superchi Stefano , Evidente Antonio , Berova Nina D. , Polavarapu Prasad L. 
Published: February 2021

AbstractSesquitepenoids inuloxins A–D, belonging to different subgroups, were isolated from Dittrichia viscosa and showed potential biocontrol of some parasitic plants as Pelipanche, Orobanche, and Cuscuta species. The absolute configurations of the first three inuloxins A–C were previously determined by using experimental and computational chiroptical spectroscopic methods. The absolute configuration of inuloxin D remains to be established. The bioactive inuloxin E, closely related to inuloxin D, was recently isolated from the same plant organic extract. The same relative configuration of inuloxin D was assigned to inuloxin E by comparison of their NMR spectroscopic data. The absolute configurations of inuloxin D and inuloxin E are suggested in this work by analysis of the experimental and predicted chiroptical properties of the 4‐O‐acetyl derivative of inuloxin D.
Multivariate functional response low‐rank regression with an application to brain imaging data
Authors: Ding Xiucai , Yu Dengdeng , Zhang Zhengwu , Kong Dehan 
Published: February 2021

AbstractWe propose a multivariate functional response low‐rank regression model with possible high‐dimensional functional responses and scalar covariates. By expanding the slope functions on a set of sieve bases, we reconstruct the basis coefficients as a matrix. To estimate these coefficients, we propose an efficient procedure using nuclear norm regularization. We also derive error bounds for our estimates and evaluate our method using simulations. We further apply our method to the Human Connectome Project neuroimaging data to predict cortical surface motor task‐evoked functional magnetic resonance imaging signals using various clinical covariates to illustrate the usefulness of our results.
Cardiac amyloidosis‐A review of current literature for the practicing physician
Authors: Ash Samantha , Shorer Eran , Ramgobin Devyani , Vo Maique , Gibbons Jonathan , Golamari Reshma , Jain Rahul , Jain Rohit 
Published: February 2021

AbstractThe amyloidoses are a family of diseases in which misfolded precursor proteins aggregate to form amyloid and deposit in body tissues. A very serious yet underrecognized form of this disease is cardiac amyloidosis, in which amyloid deposits into the extracellular space of the myocardium, resulting in thickening and stiffening of ventricular walls with resultant heart failure and conductive dysfunction. This review provides a discussion of the pathogenesis and clinical presentation of cardiac amyloidosis subtypes, as well as an up‐to‐date approach to diagnosis and treatment. Significant progress has been made in recent years regarding diagnosis and treatment of this condition, but prognosis remains heavily reliant on early detection of the disease. Two types of precursor protein are responsible for most cardiac amyloidosis cases: transthyretin amyloid, and immunoglobulin‐derived light chain amyloid. An early diagnosis of cardiac amyloidosis can allow for novel treatment modalities to be initiated with the potential to improve prognosis.
Multilevel barriers to communication in pediatric oncology: Clinicians' perspectives
Authors: Sisk Bryan A. , Friedrich Annie B. , Kaye Erica C. , Baker Justin N. , Mack Jennifer W. , DuBois James M. 
Published: February 2021

BackgroundCommunication serves several functions in pediatric oncology, but communication deficiencies persist. Little is known about the broad spectrum of barriers contributing to these deficiencies. Identifying these barriers will support new strategies to improve communication.MethodsThe authors performed 10 focus groups on perceived communication barriers with nurses, nurse practitioners, physicians, and psychosocial professionals across 2 academic institutions. They analyzed transcripts by adapting a multilevel framework from organizational psychology.ResultsThe authors identified 6 levels of barriers to communication from the clinicians' perspectives: individual, team, organization, collaborating hospital, community, and policy. Individual barriers were subdivided into clinician characteristics, family characteristics, or characteristics of the clinician‐family interaction. Within each level and sublevel, several manifestations of barriers were identified. Some barriers, such as a lack of comfort with difficult topics (individual), cultural differences (individual), a lack of a shared team mental model (team), and time pressure (organization), manifested similarly across professions and institutions. Other barriers, such as a need for boundaries (individual), intimidation or embarrassment of family (individual), unclear roles and authority (team), and excessive logistical requirements (policy), manifested differently across professions. With the exception of collaborating hospitals, participants from all professions identified barriers from each level. Physicians did not discuss collaborating hospital barriers.ConclusionsNurses, nurse practitioners, physicians, and psychosocial professionals experience communication barriers at multiple levels, which range from individual‐ to policy‐level barriers. Yet their unique clinical roles and duties can lead to different manifestations of some barriers. This multilevel framework might help clinicians and researchers to identify targets for interventions to improve communication experiences for families in pediatric oncology.Lay Summary

Clinicians and families experience many barriers to communication in pediatric oncology.

The authors performed 10 focus groups with 59 clinicians who cared for children with cancer. In these focus groups, barriers to effective communication were discussed.

In this article, the authors report on an analysis of the responses. Six levels of barriers to communication were found: individual, team, organization, collaborating hospital, community, and policy.

With an understanding of these barriers, interventions can be developed to target these barriers in hopes of improving communication for parents and patients in pediatric oncology.
A highly parallel simulation of patient‐specific hepatic flows
Authors: Lin Zeng , Chen Rongliang , Gao Beibei , Qin Shanlin , Wu Bokai , Liu Jia , Cai Xiao‐Chuan 
Published: February 2021

AbstractComputational hemodynamics is being developed as an alternative approach for assisting clinical diagnosis and treatment planning for liver diseases. The technology is non‐invasive, but the computational time could be high when the full geometry of the blood vessels is taken into account. Existing approaches use either one‐dimensional model of the artery or simplified three‐dimensional tubular geometry in order to reduce the computational time, but the accuracy is sometime compromised, for example, when simulating blood flows in arteries with plaque. In this work, we study a highly parallel method for the transient incompressible Navier–Stokes equations for the simulation of the blood flows in the full three‐dimensional patient‐specific hepatic artery, portal vein and hepatic vein. As applications, we also simulate the flow in a patient with hepatectomy and calculate the S (PPG). One of the advantages of simulating blood flows in all hepatic vessels is that it provides a direct estimate of the PPG, which is a gold standard value to assess the portal hypertension. Moreover, the robustness and scalability of the algorithm are also investigated. A 83% parallel efficiency is achieved for solving a problem with 7 million elements on a supercomputer with more than 1000 processor cores.
An efficient trust‐based secure energy‐aware clustering to mitigate trust distortion attack in mobile ad‐hoc network
Authors: Rajeswari Alagan Ramasamy , Ganapathy Sannasi , Kulothungan Kanagasabai , Kannan Arputharaj 
Published: February 2021

SummaryTrust‐aware clustering plays a vital role in addressing the security issues faced by mobile ad‐hoc networks (MANETs). The trust worthiness of each participated node is to be estimated for ensuring the secure communications in MANETs. In this article, we propose a new trust‐based secure energy‐aware clustering (TSEAC) model to mitigate the malicious nodes from the network and form secure energy aware clusters with a cluster head which is more stable and trustworthy. Moreover, two novel algorithms namely energy‐efficient trust‐aware secure clustering algorithm and filtering untrustworthy recommendation (FUR) algorithm are proposed in this work. Here, the trust value of a node is measured by both direct trust estimation and indirect trust estimation methods using the Beta distribution technique. The trust value of the node is estimated in terms of the behavior of the node. The role of the FUR algorithm is to enhance the clustering process by mitigating the trust‐distortion attack. Thus, from the simulation results it is observed that the proposed work, TSEAC outperforms in improving the lifetime of the network by 38% than the other existing work such as CBTRP, AOTDV, and CBRP. Furthermore, TSEAC shows an improvement of 20% to 24% when compared to CBTRP, 27% to 31% in contrast to AOTDV and 35% to 42% superior to CBRP in terms of packet delivery ratio. Similarly, TSEAC shows 22% to 26%, 28% to 33%, and 34% to 38% better throughput in contrast to CBTRP, AOTDV, and CBRP, respectively.
A new diagonal storage for efficient implementation of sparse matrix–vector multiplication on graphics processing unit
Authors: He Guixia , Chen Qi , Gao Jiaquan 
Published: February 2021

SummaryThe sparse matrix–vector multiplication (SpMV) is of great importance in computational science. For multidiagonal sparse matrices that have many long zero sections or scatter points, a great number of zeros are filled to maintain the diagonal structure when using the popular DIA format to store them. This leads to the performance degradation of the DIA kernel. To alleviate the drawback of DIA, we present a novel diagonal storage format, called RBDCS (diagonal compressed storage based on row‐blocks), for multidiagonal sparse matrices, and thus propose an efficient SpMV kernel that corresponds to RBDCS. Given that the RBDCS kernel codes must be manually rewritten for different multidiagonal sparse matrices, a code generator is presented to automatically generate RBDCS kernel codes. Experimental results show that the proposed RBDCS kernel is effective, and outperforms HYBMV in the CUSPARSE library, and three popular diagonal SpMV kernels: DIA, HDI, and CRSD.
Structural and Spectroscopic Properties of Benzoylpyridine‐Based Hydrazones
Authors: Mravec Bernard , Marini Anna , Tommasini Matteo , Filo Juraj , Cigáň Marek , Mantero Mariachiara , Tosi Silvano , Canepa Maurizio , Bianco Andrea 
Published: February 2021

AbstractPhotochromic hydrazones are attracting the attention in the field of photochromic systems especially due to their P‐type character. To understand the structural features and their correlation with the spectroscopic data, UV‐Vis, vibrational and ellipsometry spectroscopic techniques are employed with the support of density functional theory (DFT) calculations to three hydrazone derivatives based on benzoylpyridine. Interestingly, analysis of the structure shows the presence of two distinct rotamers around the pyridine ring with different energy and the well‐defined conjugation path that changes due to E to Z isomerization especially in the hydrazone −C=N−NH part of the skeleton. IR and Raman spectra are analyzed, showing a higher selectivity in the Z form; moreover, the comparison with the normal modes proves the effect of the reaction on the backbone structure. The experimental results are in good agreement with the theoretical predictions, especially in the case of the Raman spectrum. The molecular polarization also changes from E to Z forms as predicted by DFT calculations. Spectroscopic ellipsometry on thin films of TOPAS doped with 10 %wt of the dimethylamino hydrazone derivative is used to prove such change at the molecular level. A modulation of the refractive index is observed, and it is correlated with the concentration of the active moiety and the calculated electronic polarizabilities.
A Facile One‐Pot Synthesis of Hierarchically Organized Carbon/TiO2 Monoliths with Ordered Mesopores
Authors: Schoiber Jürgen , Koczwara Christian , Rumswinkel Simon , Whitmore Lawrence , Prehal Christian , Putz Florian , Elsaesser Michael S. , Paris Oskar , Hüsing Nicola 
Published: February 2021

AbstractSol–gel processing combined with soft templating and gelation‐induced phase separation is very sensitive to the precursor sol composition. In this work we present a straightforward synthesis towards hierarchically structured, macroporous carbon/titania monoliths with ordered mesopores derived from resorcinol/formaldehyde monoliths and a glycolated titanium precursor. We demonstrate the influence of various reaction solvents, where diol‐based media and the proportion of the catalyst seem to be essential in controlling spinodal decomposition, obtaining similar monolithic structures under different synthesis conditions. Based on these observations, we further homogeneously incorporated TiO2 into the carbon structure by an in situ synthesis approach, obtaining structural features similar to pure carbon materials with surface areas of about 400 m2 g−1, periodically arranged mesopores with a mean distance of 10–11 nm and cellular macroporosity.
Low satisfaction with normative life domains in adolescents with anorexia nervosa
Authors: van Doornik Sanne F. W. , Ostafin Brian D. , Jonker Nienke C. , Glashouwer Klaske A. , de Jong Peter J. 
Published: February 2021

AbstractObjectiveLow satisfaction with normative life domains might be an important factor in the persistence of anorexia nervosa (AN). Initial evidence in non‐clinical samples showed that lower satisfaction with normative life domains was related to more intense eating disorder symptoms. As a critical next step, the current study examined satisfaction with normative life domains in a clinical sample. Specifically, the present study tested whether adolescents with AN reported lower satisfaction with normative life domains than adolescents without an eating disorder.MethodAdolescents with AN (n = 69) and adolescents without an eating disorder matched on age, gender and educational level (n = 69) completed the Brief Multidimensional Students' Life Satisfaction Scale to assess satisfaction with five life domains (family, friendships, school, self and living location) and life in general.ResultsAdolescents with AN reported significantly lower satisfaction with normative life domains than the comparison group. Subsequent analyses showed that this overall group difference was primarily driven by adolescents with AN reporting lower satisfaction with the self, school experience and life in general.ConclusionsFindings supported the hypothesis that adolescents with AN show relatively low satisfaction with meaningful, non‐AN‐related life domains. This points to the potential relevance of enhancing satisfaction with specific life domains to optimize treatment effectiveness.
Investigating expressed emotion in individuals at‐risk of developing psychosis and their families over 12 months
Authors: Izon Emma , Berry Katherine , Wearden Alison , Carter Lesley‐Anne , Law Heather , French Paul 
Published: February 2021

AbstractHigh levels of expressed emotion (EE) are present in families of individuals with an at‐risk mental state (ARMS) of psychosis and can negatively impact on service users' functioning and symptoms, as well as relatives' psychological wellbeing.ObjectivesThis is the first longitudinal study to assess EE from the family/carers' perspective, as well as the service users' perceptions of the family/carers' EE. We explored the effects of EE on transition risk and outcomes of depression, worry, and anxiety.MethodsQuestionnaires were completed by 70 ARMS individuals and 70 family/carers at three time points: baseline, 6 and 12 months. All participants completed measures of anxiety, depression, and worry, plus a version of the Family Questionnaire to assess EE.ResultsEE scores reduced over time for both service users and family/carers. High EE perceived by service users at 6 months was associated with higher transition to psychosis at 12 months. High‐EE levels at baseline were associated with higher levels of service user depression and family/carer anxiety at 12 months. Higher family/carer total EE scores were associated with less contact with the service user and higher levels of worry.ConclusionsNovel implications suggest that interventions to reduce high EE in families of people with ARMS would benefit service users by protecting them from higher levels of depression and transition to psychosis. Reducing high‐EE attitudes would also benefit the family/carers by reducing levels of anxiety and worry. Family interventions focussing on multiple perceptions of the home environment could help to direct services and prevent negative psychological outcomes for all family members.
Post‐task modulation of resting state EEG differentiates MCI patients from controls
Authors: Kavcic Voyko , Daugherty Ana M. , Giordani Bruno 
Published: February 2021

AbstractBackground: Early identification of cognitive decline is critical for identifying individuals for inclusion in clinical trials and for eventual care planning.Methods: A sample (ages 60–90 years) of consensus‐diagnosed, community‐dwelling Blacks (61 cognitively typical [HC], 28 amnestic mild cognitive impairment [aMCI], and 14 nonamnestic MCI [naMCI]) were recruited from the Michigan Alzheimer's Disease Research Center and the Wayne State University Institute of Gerontology. Participants received two resting state electroencephalograms (rsEEG, eyes closed) between which they engaged in a visual motion direction discrimination task. rsEEG %change current source densities across all frequency bands and regions of interest were calculated.Results: EEG current density was not different across groups for pre‐task resting state. However, compared to HC, aMCI showed significantly greater declines at temporal and central cortical sites, while naMCI showed significant parietal declines.Conclusion: This novel approach of post–pre/cognitive challenge rsEEG successfully discriminated older persons with MCI from those without was sensitive to cognitive decline.