bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of analytical reasoning and source credibility on the evaluation of real and fake full-length news articles
Authors: Pehlivanoglu Didem , Lin Tian , Deceus Farha , Heemskerk Amber , Ebner Natalie C. , Cahill Brian S. 
Published: March 2021

AbstractAimPrevious research has focused on accuracy associated with real and fake news presented in the form of news headlines only, which does not capture the rich context news is frequently encountered in real life. Additionally, while previous studies on evaluation of real and fake news have mostly focused on characteristics of the evaluator (i.e., analytical reasoning), characteristics of the news stimuli (i.e., news source credibility) and the interplay between the two have been largely ignored. To address these research gaps, this project examined the role of analytical reasoning and news source credibility on evaluation of real and fake full-length news story articles. The project considered both accuracy and perceived credibility ratings as outcome variables, thus qualifying previous work focused solely on news detection accuracy.MethodWe conducted two independent but parallel studies, with Study 2 as a direct replication of Study 1, employing the same design but in a larger sample (Study 1:N = 292 vs. Study 2:N = 357). In both studies, participants viewed 12 full-length news articles (6 real, 6 fake), followed by prompts to evaluate each article’s veracity and credibility. Participants were randomly assigned to view articles with a credible or non-credible source and completed the Cognitive Reflection Test as well as short demographic questions.FindingsConsistent across both studies, higher analytical reasoning was associated with greater fake news accuracy, while analytical reasoning was not associated with real news accuracy. In addition, in both studies, higher analytical reasoning was associated with lower perceived credibility for fake news, while analytical reasoning was not associated with perceived credibility for real news. Furthermore, lower analytical reasoning was associated with greater accuracy for real (but not fake) news from credible compared to non-credible sources, with this effect only detected in Study 2.ConclusionsThe novel results generated in this research are discussed in light of classical vs. naturalistic accounts of decision-making as well as cognitive processes underlying news articles evaluation. The results extend previous findings that analytical reasoning contributes to fake news detection to full-length news articles. Furthermore, news-related cues such as the credibility of the news source systematically affected discrimination ability between real and fake news.
An end-to-end text spotter with text relation networks
Authors: Jiang Jianguo , Wei Baole , Yu Min , Li Gang , Li Boquan , Liu Chao , Li Min , Huang Weiqing 
Published: March 2021

AbstractReading text in images automatically has become an attractive research topic in computer vision. Specifically, end-to-end spotting of scene text has attracted significant research attention, and relatively ideal accuracy has been achieved on several datasets. However, most of the existing works overlooked the semantic connection between the scene text instances, and had limitations in situations such as occlusion, blurring, and unseen characters, which result in some semantic information lost in the text regions. The relevance between texts generally lies in the scene images. From the perspective of cognitive psychology, humans often combine the nearby easy-to-recognize texts to infer the unidentifiable text. In this paper, we propose a novel graph-based method for intermediate semantic features enhancement, called Text Relation Networks. Specifically, we model the co-occurrence relationship of scene texts as a graph. The nodes in the graph represent the text instances in a scene image, and the corresponding semantic features are defined as representations of the nodes. The relative positions between text instances are measured as the weights of edges in the established graph. Then, a convolution operation is performed on the graph to aggregate semantic information and enhance the intermediate features corresponding to text instances. We evaluate the proposed method through comprehensive experiments on several mainstream benchmarks, and get highly competitive results. For example, on the , our method surpasses the previous top works by 2.1% on the word spotting task.
Outcome of the use of 0.9% saline versus 0.45% saline for fluid rehydration in moderate and severe diabetic ketoacidosis in children
Authors: Badawi Nora El Said , Hafez Mona , Eldin Heba Sharaf , Abdelatif Hend Mehawed , Atef Shimaa , Ismail Mohamed Mohamed , Arafa Noha 
Published: March 2021

Abstract
Background
The debate for the optimum sodium concentration in the rehydration solution in diabetic ketoacidosis (DKA) persists till the moment. The aim was to compare the outcome of 0.9% saline versus 0.45% saline in children with moderate and severe (DKA) regarding the effect on serum electrolytes, duration of DKA resolution and the incidence of hyperchloremia.

Results
A retrospective analysis of 121 children with moderate or severe DKA was done. After the initial 4 h in which both groups received normal saline, patients were divided into two groups continuing on 0.9% (N=72) or switched to 0.45% saline (N=49). Serum chloride and Cl/Na ratios were significantly higher in 0.9% saline group at 4 and 8 h. The 0.9% saline group had significantly higher proportion of hyperchloremia at 4 and 8 h (P value: 0.002, 0.02). The median duration of correction of DKA (14 h among 0.9% saline versus 10 h among 0.45% saline) without significant difference (P value= 0.43). The change in plasma glucose, effective osmolarity, corrected Na levels were comparable between groups.

Conclusion
There is an unavoidable iatrogenically induced rise in serum chloride with higher incidence of hyperchloremia with the use of normal saline in rehydration of children presenting in DKA and shock. The use of 0.45% saline as post-bolus rehydration fluid is not associated with a decline in the corrected serum sodium concentration and does not affect the rate of correction of acidosis or rate of drop in blood glucose or duration of DKA resolution when compared to normal saline.
Lifelong Exercise in Age Rats Improves Skeletal Muscle Function and MicroRNA Profile
Authors: GAO HAO-EN , LI FANG-HUI , XIE TIAN , MA SONG , QIAO YI-BO , WU DA-SHUAI , SUN LEI 
Published: March 2021

ABSTRACT

Purpose
Lifelong exercise is known to attenuate sarcopenia (age-associated reduction in muscle mass and function); however, the underlying molecular mechanisms remain unclear. As microRNAs are widely involved in the regulation of skeletal muscle growth and development, we aimed to evaluate the effects of lifelong regular exercise on age-related alterations in muscle microRNA expression profiles as well as on skeletal muscle atrophy, apoptosis, and mitochondria and autophagy dysfunction.

Methods
Female 8-month-old Sprague-Dawley rats were divided into four groups; 1) 18 months of moderate-intensity continuous training (MICT) initiated at 8 months (adult-MICT, n = 12), 2) 8 months of MICT initiated at 18 months (presarcopenia-MICT, n = 12), 3) 8-month-old adult sedentary controls (adult-SED), and 4) 26-month-old aging sedentary controls (old-SED). Age skeletal muscles were then subjected to quantitative reverse transcription–polymerase chain reaction, Kyoto Encyclopedia of Genes and Genomes, immunoblotting, and miR-486 3′ untranslated region luciferase reporter gene analyses.

Results
Age-related loss of miR-486 expression was improved, skeletal muscle atrophy and apoptosis were downregulated, and mitochondrial activity and autophagy were upregulated in the adult-MICT group. Kyoto Encyclopedia of Genes and Genomes analysis revealed that the PI3K/Akt pathway was upregulated in adult-MICT rats compared with that in old-SED. In vitro analyses in rat skeletal muscle L6 cells further confirmed that miR-486 targets PTEN, not SAV1, thereby activating the PI3K/Akt pathway and indirectly inhibiting HIPPO signaling.

Conclusions
Compared with presarcopenia-MICT rats, adult-MICT rats experienced greater beneficial effects regarding ameliorated age-related alterations in muscle miRNA expression profile, skeletal muscle atrophy, apoptosis, and mitochondria and autophagy dysfunction, which is potentially associated with the increased miR-486 expression and concomitant targeting of the PTEN/Akt signaling pathway.
Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation
Authors: Mills Mark T , Grafton-Clarke Ciaran , Williams Gareth , Gosling Rebecca C , Al Baraikan Abdulaziz , Kyriacou Andreas L , Morris Paul D , Gunn Julian P , Swoboda Peter P , Levelt Eylem , Tsampasian Vasiliki , van der Geest Rob J , Swift Andrew J , Greenwood John P , Plein Sven , Vassiliou Vass , Garg Pankaj 
Published: March 2021

Background: Four-dimensional (4D) flow cardiovascular magnetic resonance imaging (MRI) is an emerging technique used for intra-cardiac blood flow assessment. The role of 4D flow cardiovascular MRI in the assessment of trans-valvular flow in patients with atrial fibrillation (AF) has not previously been assessed. The purpose of this study was to assess the feasibility, image quality, and internal validity of 4D flow cardiovascular MRI in the quantification of trans-valvular flow in patients with AF. Methods: Patients with AF and healthy controls in sinus rhythm underwent cardiovascular MRI, including 4D flow studies. Quality assurance checks were done on the raw data and streamlines. Consistency was investigated by trans-valvular flow assessment between the mitral valve (MV) and the aortic valve (AV). Results: Eight patients with AF (88% male, mean age 62±13 years, mean heart rate (HR) 83±16 beats per minute (bpm)) were included and compared with ten healthy controls (70% male, mean age 41±20 years, mean HR 68.5±9 bpm). All scans were of either good quality with minimal blurring artefacts, or excellent quality with no artefacts. No significant bias was observed between the AV and MV stroke volumes in either healthy controls (–4.8, 95% CI –15.64 to 6.04; P=0.34) or in patients with AF (1.64, 95% CI –4.7 to 7.94; P=0.56). A significant correlation was demonstrated between MV and AV stroke volumes in both healthy controls (r=0.87, 95% CI 0.52 to 0.97; P=0.001) and in AF patients (r=0.82, 95% CI 0.26 to 0.97; P=0.01). Conclusions: In patients with AF, 4D flow cardiovascular MRI is feasible with good image quality, allowing for quantification of trans-valvular flow.
Optimal Priority-Based Allocation Mechanisms
Authors: Shi Peng 
Published: March 2021

This paper develops a tractable methodology for designing an optimal priority system for assigning agents to heterogeneous items while accounting for agents’ choice behavior. The space of mechanisms being optimized includes deferred acceptance and top trading cycles as special cases. In contrast to previous literature, I treat the inputs to these mechanisms, namely the priority distribution of agents and quotas of items, as parameters to be optimized. The methodology is based on analyzing large market models of one-sided matching using techniques from revenue management and solving a certain assortment planning problem whose objective is social welfare. I apply the methodology to school choice and show that restricting choices may be beneficial to student welfare. Moreover, I compute optimized choice sets and priorities for elementary school choice in Boston. This paper was accepted by Gabriel Weintraub, revenue management and market analytics.
Exposure to formaldehyde and asthma outcomes: A systematic review, meta-analysis, and economic assessment
Authors: Lam Juleen , Koustas Erica , Sutton Patrice , Padula Amy M. , Cabana Michael D. , Vesterinen Hanna , Griffiths Charles , Dickie Mark , Daniels Natalyn , Whitaker Evans , Woodruff Tracey J. 
Published: March 2021

Background
Every major federal regulation in the United States requires an economic analysis estimating its benefits and costs. Benefit-cost analyses related to regulations on formaldehyde exposure have not included asthma in part due to lack of clarity in the strength of the evidence.

Objectives
1) To conduct a systematic review of evidence regarding human exposure to formaldehyde and diagnosis, signs, symptoms, exacerbations, or other measures of asthma in humans; and 2) quantify the annual economic benefit for decreases in formaldehyde exposure.

Methods
We developed and registered a protocol in PROSPERO (Record ID #38766, CRD 42016038766). We conducted a comprehensive search of articles published up to April 1, 2020. We evaluated potential risk of bias for included studies, identified a subset of studies to combine in a meta-analysis, and rated the overall quality and strength of the evidence. We quantified economics benefit to children from a decrease in formaldehyde exposure using assumptions consistent with EPA’s proposed formaldehyde rule.

Results
We screened 4,821 total references and identified 150 human studies that met inclusion criteria; of these, we focused on 90 studies reporting asthma status of all participants with quantified measures of formaldehyde directly relevant to our study question. Ten studies were combinable in a meta-analysis for childhood asthma diagnosis and five combinable for exacerbation of childhood asthma (wheezing and shortness of breath). Studies had low to probably-low risk of bias across most domains. A 10-μg/m3 increase in formaldehyde exposure was associated with increased childhood asthma diagnosis (OR = 1.20, 95% CI: [1.02, 1.41]). We also found a positive association with exacerbation of childhood asthma (OR = 1.08, 95% CI: [0.92, 1.28]). The overall quality and strength of the evidence was rated as “moderate” quality and “sufficient” for asthma diagnosis and asthma symptom exacerbation in both children and adults. We estimated that EPA’s proposed rule on pressed wood products would result in 2,805 fewer asthma cases and total economic benefit of $210 million annually.

Conclusion
We concluded there was “sufficient evidence of toxicity” for associations between exposure to formaldehyde and asthma diagnosis and asthma symptoms in both children and adults. Our research documented that when exposures are ubiquitous, excluding health outcomes from benefit-cost analysis can underestimate the true benefits to health from environmental regulations.
Delivering patient care during large-scale emergency situations: Lessons from military care providers
Authors: Varpio Lara , Bader-Larsen Karlen , Hamwey Meghan , Durning Steven , Meyer Holly , Cruthirds Danette , Artino Anthony 
Published: March 2021

Background
Today, physicians are at the front lines of a pandemic response. Military physicians are uniquely trained to excel in such large-scale emergency situations. Civilian physicians can harness military know-how, but it will require research into military healthcare responses—specifically, we need to learn lessons from military interprofessional healthcare teams (MIHTs).

Methods
This research answers two questions: What are the characteristics of successful MIHTs? Why are those characteristics important to MIHT success in large-scale emergency situations? Using a Grounded Theory approach, 30 interviews were conducted soliciting perspectives from the broadest range of healthcare professionals who had experiences working in and leading MIHTs. Purposive sampling was used to recruit participants broadly across: contexts where MIHTs work; military branches; ranks; genders; and healthcare professions. Data were iteratively collected and analyzed.

Results
30 participants were interviewed (18 male (60%); 21 officers (70%); 9 enlisted (30%)) who held various healthcare occupations (medic/tech/corpsman (9); nurse (7); physician (7); dentist (2); occupational therapist (2); chaplain (1); physician’s assistant (1); and psychiatrist (1)).
Six characteristics of successful MIHTs that are directly applicable to large-scale emergency situations were identified thatthat clustered into two themes: own your purposes and responsibilities (through mission focus and ethical bearing) and get it done, safely (via situational awareness, adaptability, and leadership with followership).

Conclusions
This study provides insights, informed by decades of military service and training, to help civilian physicians succeed in large-scale emergency situations. These experiences from the war front can support today’s pandemic responses on the home front.
Impact of the COVID-19 pandemic on skin cancer diagnosis: A population-based study
Authors: Asai Yuka , Nguyen Paul , Hanna Timothy P. 
Published: March 2021

Background
The COVID-19 pandemic has been unprecedented and has led to drastic reductions in non-urgent medical visits. Deferral of these visits may have critical health impact, including delayed diagnosis for melanoma and other skin cancers. We examined the influence of the pandemic on skin biopsy rates in a large population-based cohort.

Methods
Using a universal health care claims dataset from Ontario, we examined skin biopsies from January 6, 2020 to September 27, 2020, and compared these to the same period for 2019. Those diagnosed with anogenital cancers, younger than 20 years, residing out-of-province and with lapses in coverage were excluded. The sensitivity and specificity of claims diagnoses compared to a validated algorithm to identify keratinocyte carcinoma (KC), or to the cancer registry for melanoma was evaluated. Factors associated with biopsy during the early pandemic were investigated with modified Poisson regression.

Results
A precipitous drop in total skin biopsies (15% of expected), biopsies for KC (18%) and melanoma (27%) was seen with the onset of COVID-19 cases (p<0.01). Claims diagnoses were of high specificity for KC (99%), and for melanoma (98%), though sensitivity was less (61%, 28% respectively). In adjusted analysis, the elderly (80+ years), females and residents of certain regions were less likely to be biopsied during the pandemic. Subsequently, there were substantial improvements in biopsy rates over 10 weeks. However, compared to 2019, a large backlog of expected cases still remained 28 weeks after lockdown (45,710 all biopsy, 9,104 KC, 595 melanoma).

Interpretation
A drastic reduction in skin biopsies is noted early in the COVID-19 pandemic; this disproportionately affected the elderly, females and certain geographic regions. Though biopsies subsequently increased, a large backlog of cases remained after almost half a year. This will have implications for downstream care of skin cancer. Efforts should be made to limit diagnostic delay.
Community participation in the collaborative governance of primary health care facilities, Uasin Gishu County, Kenya
Authors: Sitienei Jackline , Manderson Lenore , Nangami Mabel 
Published: March 2021

Introduction
Community participation in the governance of health services is an important component in engaging stakeholders (patients, public and partners) in decision-making and related activities in health care. Community participation is assumed to contribute to quality improvement and goal attainment but remains elusive. We examined the implementation of community participation, through collaborative governance in primary health care facilities in Uasin Gishu County, Western Kenya, under the policy of devolved governance of 2013.

Methods
Utilizing a multiple case study methodology, five primary health care facilities were purposively selected. Study participants were individuals involved in the collaborative governance of primary health care facilities (from health service providers and community members), including in decision-making, management, oversight, service provision and problem solving. Data were collected through document review, key informant interviews and observations undertaken from 2017 to 2018. Audio recording, notetaking and a reflective journal aided data collection. Data were transcribed, cleaned, coded and analysed iteratively into emerging themes using a governance attributes framework.

Findings
A total of 60 participants representing individual service providers and community members participated in interviews and observations. The minutes of all meetings of five primary health care facilities were reviewed for three years (2014–2016) and eight health facility committee meetings were observed. Findings indicate that in some cases, structures for collaborative community engagement exist but functioning is ineffective for a number of reasons. Health facility committee meetings were most frequent when there were project funds, with discussions focusing mainly on construction projects as opposed to the day-to-day functioning of the facility. Committee members with the strongest influence and power had political connections or were retired government workers. There were no formal mechanisms for stakeholder forums and how these worked were unclear. Drug stock outs, funding delays and unclear operational guidelines affected collaborative governance performance.

Conclusion
Implementing collaborative governance effectively requires that the scope of focus for collaboration include both specific projects and the routine functioning of the primary health care facility by the health facility committee. In the study area, structures are required to manage effective stakeholder engagement.
Transcriptome analysis of the impact of exogenous methyl jasmonate on the opening of sorghum florets
Authors: Liu Suifei , Fu Yongqi , He Yongming , Zeng Xiaochun 
Published: March 2021

Background
Methyl Jasmonate (MeJA) could promote the opening of sorghum florets, but the molecular mechanism remains unclear.

Objective
We aimed to investigate the molecular mechanism of exogenous MeJA in promoting the opening of sorghum florets.

Methods
Hybrid sorghum Aikang-8 was selected as the test material in this study. Sorghum plants of uniform growth with approximately 20%-25% florets open were selected and treated with 0, 0.5 and 2.0 mmol/L of MeJA. Totally there were 27 samples with lodicules removed were obtained at different time points and used for the transcriptome analysis using the BGISEQ_500RS platform.

Results
The results showed the sorghum florets opened earlier than the control after the treatment with exogenous MeJA, and the promotive effect increased along with the increase of exogenous MeJA concentration. The number of differentially expressed genes (DEGs) in plasma cells increased with the increase of MeJA concentration, whether up- or down-regulated, after the exogenous MeJA treatment. Besides, the number of metabolic pathways was also positively correlated with the concentration of MeJA. GO and KEGG analysis suggested the DEGs were mainly enriched in starch and sucrose metabolism-related pathways (i.e., LOC8063704, LOC8083539 and LOC8056206), plant hormone signal transduction pathways (i.e., LOC8084842, LOC8072010, and LOC8057408), energy metabolic pathway (i.e., LOC8076139) and the α-linolenic acid metabolic pathway (i.e., LOC8055636, LOC8057399, LOC8063048 and LOC110430730). Functional analysis of target genes showed that two genes named LOC-1 (LOC8063704) and LOC-2 (LOC8076139) could induce the earlier flowering of Arabidopsis thaliana.

Conclusion
The results of this study suggest that exogenous MeJA treatments could induce the up- or down- regulation of genes related to starch and sucrose metabolism, -linolenic acid metabolism and plant hormone signal transduction pathways in the plasma cells of sorghum florets, thereby promoting the opening of sorghum florets.