bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shareholders’ greed and corporate value growth
Authors: Teti Emanuele , Gori Leonella , Magnanini Veronica 
Published: March 2021

Abstract
This article investigates whether companies with a higher payout ratio make fewer investments, to evaluate how firms make their decisions about corporate value creation. Furthermore, it examines how this yearning for dividends and the corresponding earning distribution affect the value creation for the shareholders in the long term. The findings show that companies with a higher level of dividends make fewer investments and deliver a lower return for shareholders. Higher levels of dividends generally imply a lower amount of resources to reinvest, negatively affecting long-term growth investing. Overall, the main insight is that the investor’s “greed” and appetite for short-term results (in forms of dividends), drove a lower performance and creation of value for the same shareholders. The companies more oriented to the long term, in terms of investments and growth, reached a superior value.
An overview of CAR T-cell clinical trial activity to 2021
Authors: Adami Antonella , Maher John 
Published: March 2021

SummaryImmunotherapy of cancer using chimeric antigen receptor-engineered T-cells has transformed the management of selected haematological malignancies, triggering intense clinical trial activity in this arena. This article summarises trial activity that has been published to date across the spectrum of haematological and solid tumour types.
Positivity of Curvature On Manifolds With Boundary
Authors: Chow Tsz-Kiu Aaron 
Published: March 2021

Abstract
Consider a compact manifold $M$ with smooth boundary $\partial M$. Suppose that $g$ and $\tilde{g}$ are two Riemannian metrics on $M$. We construct a family of metrics on $M$ that agrees with $g$ outside a neighborhood of $\partial M$ and agrees with $\tilde{g}$ in a neighborhood of $\partial M$. We prove that the family of metrics preserves various natural curvature conditions under suitable assumptions on the boundary data. Moreover, under suitable assumptions on the boundary data, we can deform a metric to one with totally geodesic boundary while preserving various natural curvature conditions.
Trace amounts of antibiotic exacerbated diarrhea and systemic
inflammation of weaned pigs infected with a pathogenic Escherichia
coli
Authors: Kim Kwangwook , He Yijie , Jinno Cynthia , Kovanda Lauren , Li Xunde , Song Minho , Liu Yanhong 
Published: March 2021

Abstract
The experiment was conducted to investigate the effects of trace amounts of antibiotic on growth performance, diarrhea, systemic immunity, and intestinal health of weaned pigs experimentally infected with an enterotoxigenic Escherichia coli. Weaned pigs (n = 34, 6.88 ± 1.03 kg body weight [BW]) were individually housed in disease containment rooms and randomly allotted to one of the three dietary treatments: nursery basal diet (CON) and two additional diets supplemented with 0.5 or 50 mg/kg carbadox to the nursery basal diet (TRA or REC), respectively. The experiment lasted 18 d with 7 d before and 11 d after the first E. coli inoculation. The E. coli F18 inoculum was orally provided to all pigs with a dose of 1010 colony-forming unit (CFU)/3 mL for three consecutive days. Fecal and blood samples were collected on day 0 before inoculation and days 2, 5, 8, and 11 postinoculation (PI) to test the percentage of β-hemolytic coliforms in total coliforms and complete blood cell count, respectively. Sixteen pigs were euthanized on day 5 PI, whereas the remaining pigs were euthanized at the end of the experiment to collect the jejunal and ileal mucosa and mesenteric lymph node for gene expression and bacterial translocation, respectively. Pigs in REC had greater (P &lt; 0.05) final BW and lower (P &lt; 0.05) overall frequency of diarrhea compared with pigs in the CON and TRA groups. Pigs in TRA had the lowest (P &lt; 0.05) average daily gain and feed efficiency from day 0 to 5 PI, highest (P &lt; 0.05) percentage of β-hemolytic coliforms in fecal samples on days 2 and 5 PI, and greatest (P &lt; 0.05) bacterial colonies in mesenteric lymph nodes on day 11 PI compared with pigs in the CON and REC groups. Pigs in TRA had the greatest (P &lt; 0.05) neutrophils on day 5 PI and higher (P &lt; 0.05) white blood cell counts and lymphocytes than other groups on day 11 PI. Pigs in TRA had the greatest (P &lt; 0.05) serum C-reactive protein on days 2 and 5 PI and serum tumor necrosis factor-α on day 5 PI, compared with pigs in the CON and REC groups. Pigs fed REC had increased (P &lt; 0.05) mRNA expression of zona occludens-1 (ZO-1) and occludin (OCDN) and reduced (P &lt; 0.05) interleukin-1 beta (IL1B), interleukin-6 (IL6), and tumor necrosis factor-alpha (TNFA) in ileal mucosa on day 5 PI, compared with the CON, whereas TRA upregulated (P &lt; 0.05) mRNA expression of IL1B, IL6, and cyclooxygenase-2 (COX2) in the ileal mucosa on day 11 PI, compared with the REC. In conclusion, trace amounts of antibiotic may exacerbate the detrimental effects of E. coli infection on pig performance by increasing diarrhea and systemic inflammation of weanling pigs.
Inhibition of prolactin promotes secondary skin follicle activation in cashmere goats
Authors: Zhang Lechao , Duan Chunhui , Guo Yunxia , Zhang Yingjie , Liu Yueqin 
Published: March 2021

Abstract
The aim of this study was to investigate the involvement of prolactin (PRL) on development of secondary skin follicles in cashmere goats. Goats were randomly assigned to either a bromocriptine treatment or control group. Samples of cashmere fiber, blood, and skin were collected from all goats after 1 mo. The results indicated that the length, growth rate, and diameter of fibers were not influenced (P &gt; 0.05) by the inhibition of PRL resulting from the treatment with bromocriptine. There was a tendency for increases in total follicle number, primary and secondary follicle numbers, and in the ratio of secondary to primary follicles following treatment with bromocriptine, but these differences were not significant (P &gt; 0.05). The percentage of active secondary follicles in anagen was increased (P &lt; 0.05) in the bromocriptine-treated goats, but there was no effect of treatment on the percentage of active primary follicles. Bromocriptine decreased (P &lt; 0.05) circulating concentrations of PRL and Insulin-like growth factor 1 (IGF1) and increased (P &lt; 0.05) those of melatonin (MT), but there was no effect of this treatment on the serum concentrations of cortisol, growth hormone, tetraiodothyronine, and triiodothyronine. In bromocriptine-treated goats, mRNA expressions of PRL and MT membrane receptor 1a (MTNR1a) were decreased (P &lt; 0.05) and mRNA expression of MT nuclear receptor (RORα) was increased (P &lt; 0.05), but there was no effect of the treatment on expression of long PRL receptor, short PRL receptor, MT membrane receptor 1b and IGF1. It is concluded that inhibition of PRL promotes secondary hair follicle development in the anagen phase, possibly by downregulating MTNR1a and up-regulating RORα gene expression in the skin.
How Do Platforms Empower Consumers? Insights from the Affordances and Constraints of Reclame Aqui
Authors: Kozinets Robert V , Ferreira Daniela Abrantes , Chimenti Paula 
Published: March 2021

Abstract
Consumer feedback platforms offer consumers tools to provide feedback on their market and consumption experiences. Beyond broad prior characterizations, little is known about the specific means by which platforms affect empowerment. Elements of empowerment identified in extant studies include voice, choice, justice, inclusion, catalysis, and consciousness-raising. We research a popular Brazilian platform to learn how platforms facilitate and constrain consumer empowerment. Our approach is immersive, a more-than-human netnography of the platform involving depth interviews with twenty-one of its consumer and corporate users. Findings show same-side and cross-side network effects driving the ability of the platform to offer consumers empowerment. Furthermore, affordances are critically important. Affordances provide opportunities for consumer choice, voice, justice, and inclusion. However, platforms’ cross-side network effects create economic considerations that limit those opportunities in theoretically and practically important ways. Although other feedback platforms might offer catalysis and consciousness-raising elements of empowerment, our focal platform does not. Earlier studies of consumer empowerment on the Internet may have been overly general and exuberant because they failed to recognize the constraining impacts of network effects, affordances, and algorithms. Consumer-citizenry, collective action, and consumer power are thoroughly transformed in the age of the platform, opening up new spaces for further investigation.
Comparative Virulence ofMetarhizium anisopliaeand Four Strains ofBeauveria bassianaAgainst House Fly (Diptera: Muscidae) Adults With Attempted Selection for Faster Mortality
Authors: White Roxie L , Geden Christopher J , Kaufman Phillip E , Johnson Dana 
Published: March 2021

AbstractEntomopathogenic fungi such as Beauveria bassiana (Balsamo) Vuillemin and Metarhizium anisopliae/brunneum (Metchnikoff)/Petch have shown promising results for managing the house fly, Musca domestica L. A primary challenge of using these biological control agents (BCAs) in field situations is the time required to induce high adult house fly mortality, typically 6–7 d post-exposure. In this study, virulence of M. anisopliae (strain F52) and four B. bassiana strains were compared. The B. bassiana strains GHA and HF23 are used in commercial products and those were compared with two strains that were isolated from house flies on dairy farms (NFH10 and L90). Assays were conducted by exposing adult house flies to fungal-treated filter paper disks for 2 h. The lethal time to 50% mortality (LT50) at the high concentration of 1 × 109 conidia ranged from 3.8 to 5.2 d for all five strains. GHA, NFH10, and L90 killed flies faster than M. anisopliae strain F52; HF23 did not differ from either the M. anisopliae or the other B. bassiana strains. Attempts with the NFH10 strain to induce faster fly mortality through selection across 10 fungal to fly passages did not result in shorter time to fly death of the selected strain compared with the unselected strain.
α-Glucosidase and advanced glycation end products inhibition with Vernonia amygdalina root and leaf extracts: new data supporting the antidiabetic properties
Authors: Medjiofack Djeujo Francine , Cusinato Federico , Ragazzi Eugenio , Froldi Guglielmina 
Published: March 2021

Abstract

Objective
This study aims to investigate antidiabetic activity of several Vernonia amygdalina extracts to study their potential use in medicine.

Methods
Aqueous and ethanol extracts were obtained by maceration and Soxhlet extraction from roots and leaves of V. amygdalina. The extracts were tested as inhibitors of α-glucosidase activity and of advanced glycation end products (AGEs) formation. Further, radical scavenging activity was examined detecting the oxygen radical absorbance capacity, while the potential cytotoxicity of extracts was estimated with MTT assay.

Key findings
In aqueous and ethanol extracts, several polyphenolic compounds were identified; in detail, (-)-catechin and luteolin were found in leaf extracts, while caffeic acid, chlorogenic acid and the terpenoid vernodalol were recognized in root extracts. Regarding antidiabetic activity, the aqueous root extracts efficiently inhibited α-glucosidase activity in a concentration-dependent manner (IC50 = 5.6 µg/ml and 39.8 µg/ml, respectively of macerated and Soxhlet extracts), whereas those obtained from leaves exhibited lower potency. Furthermore, AGEs formation was reduced by all V. amygdalina extracts starting from 10 µg/ml.

Conclusions
The aqueous extracts of V. amygdalina roots obtained by maceration and Soxhlet extraction show remarkable anti-α-glucosidase activity, and all extracts have favourable antiglycation and antioxidant activities.
Hilarious Homicides: Satirizing Sensational Murders in Late Nineteenth-Century London
Authors: Michael-Berger Lee 
Published: March 2021

Abstract
Whereas many studies consider the nineteenth-century fascination with murder as synonymous with the contemporary cultural tendency towards sensation and melodrama, this article offers a fresh perspective on the subject. Here, I deal with a corpus of humorous murder representations, which have rarely been addressed before. I examine how murder was comically represented and look at the contemporary discourse on murder, through the investigation of sources including music hall songs, cartoons, and theatrical travesties, with an emphasis on visual representations. In the context of the democratization of culture, the article examines the importance of murder in the elite claim to cultural authority versus its perception of plebian taste. It demonstrates how late nineteenth-century notions of modernity, which were crystallized through the discussion of murder, were classed and gendered. Thus, a hidden discourse is exposed, in which murder serves as a central tool in a mechanism similar to Bourdieu’s theory of distinction, where cultural and artistic ‘taste’ has a social dimension.
Transcriptomics reveal new insights into molecular regulation of nitrogen use efficiency inSolanum melongena
Authors: Mauceri Antonio , Abenavoli Maria Rosa , Toppino Laura , Panda Sayantan , Mercati Francesco , Aci Meriem Miyassa , Aharoni Asaph , Sunseri Francesco , Rotino Giuseppe Leonardo , Lupini Antonio 
Published: March 2021

AbstractNitrogen-use efficiency (NUE) is a complex trait of great interest in breeding programs because through its improvement, high crop yields can be maintained whilst N supply is reduced. In this study, we report a transcriptomic analysis of four NUE-contrasting eggplant (Solanum melongena) genotypes following short- and long-term exposure to low N, to identify key genes related to NUE in the roots and shoots. The differentially expressed genes in the high-NUE genotypes are involved in the light-harvesting complex and receptor, a ferredoxin–NADP reductase, a catalase and WRKY33. These genes were then used as bait for a co-expression gene network analysis in order to identify genes with the same trends in expression. This showed that up-regulation of WRKY33 triggered higher expression of a cluster of 21 genes and also of other genes, many of which were related to N-metabolism, that were able to improve both nitrogen uptake efficiency and nitrogen utilization efficiency, the two components of NUE. We also conducted an independent de novo experiment to validate the significantly higher expression of WRKY33 and its gene cluster in the high-NUE genotypes. Finally, examination of an Arabidopsis transgenic 35S::AtWRKY33 overexpression line showed that it had a bigger root system and was more efficient at taking up N from the soil, confirming the pivotal role of WRKY33 for NUE improvement.
Painting international law as universal: imperialism and the co-opting of image and art
Authors: Miles Kate 
Published: March 2021

Abstract
Visual international law tells stories. Image and art supporting imperialism in the eighteenth and nineteenth centuries also projected the authority and universalism of international law. This article argues that depictions of treaty-making, of international legal theorists, and of conferences were about painting European international law as ‘successful’—telling stories of an authoritative, universal, and virtue-laden mode of international regulation.
Characteristics of Opioid Prescriptions to Veterans With Chronic Gastrointestinal Symptoms and Disorders Dually Enrolled in the Department of Veterans Affairs and Medicare Part D
Authors: Balbale Salva N , Cao Lishan , Trivedi Itishree , Stulberg Jonah J , Suda Katie J , Gellad Walid F , Evans Charlesnika T , Lambert Bruce L , Keefer Laurie A , Jordan Neil 
Published: March 2021

ABSTRACT

Introduction
Gastrointestinal (GI) symptoms and disorders affect an increasingly large group of veterans. Opioid use may be rising in this population, but this is concerning from a patient safety perspective, given the risk of dependence and lack of evidence supporting opioid use to manage chronic pain. We examined the characteristics of opioid prescriptions and factors associated with chronic opioid use among chronic GI patients dually enrolled in the DVA and Medicare Part D.

Materials and Methods
In this retrospective cohort study, we used linked, national patient-level data (from April 1, 2011, to December 31, 2014) from the VA and Centers for Medicare & Medicaid Services to identify chronic GI patients and observe opioid use. Veterans who had a chronic GI symptom or disorder were dually enrolled in VA and Part D and received ≥1 opioid prescription dispensed through the VA, Part D, or both. Chronic GI symptoms and disorders included chronic abdominal pain, chronic pancreatitis, inflammatory bowel diseases, and functional GI disorders. Key outcome measures were outpatient opioid prescription dispensing overall and chronic opioid use, defined as ≥90 consecutive days of opioid receipt over 12 months. We described patient characteristics and opioid use measures using descriptive statistics. Using multiple logistic regression modeling, we generated adjusted odds ratios and 95% CIs to determine variables independently associated with chronic opioid use. The final model included variables outlined in the literature and our conceptual framework.

Results
We identified 141,805 veterans who had a chronic GI symptom or disorder, were dually enrolled in VA and Part D, and received ≥1 opioid prescription dispensed from the VA, Part D, or both. Twenty-six percent received opioids from the VA only, 69% received opioids from Medicare Part D only, and 5% were “dual users,” receiving opioids through both VA and Part D. Compared to veterans who received opioids from the VA or Part D only, dual users had a greater likelihood of potentially unsafe opioid use outcomes, including greater number of days on opioids, higher daily doses, and higher odds of chronic use.

Conclusions
Chronic GI patients in the VA may be frequent users of opioids and may have a unique set of risk factors for unsafe opioid use. Careful monitoring of opioid use among chronic GI patients may help to begin risk stratifying this group. and develop tailored approaches to minimize chronic use. The findings underscore potential nuances within the opioid epidemic and suggest that components of the VA’s Opioid Safety Initiative may need to be adapted around veterans at a higher risk of opioid-related adverse events.
Applying clock comparison methods to pulsar timing observations
Authors: Chen Siyuan , Vernotte François , Rubiola Enrico 
Published: March 2021

ABSTRACT
Frequency metrology outperforms any other branch of metrology in accuracy (parts in 10−16) and small fluctuations (&lt;10−17). In turn, among celestial bodies, the rotation speed of millisecond pulsars is by far the most stable (&lt;10−18). Therefore, the precise measurement of the time of arrival (TOA) of pulsar signals is expected to disclose information about cosmological phenomena, and to enlarge our astrophysical knowledge. Related to this topic, Pulsar Timing Array projects have been developed and operated for the last decades. The TOAs from a pulsar can be affected by local emission and environmental effects, in the direction of the propagation through the interstellar medium or universally by gravitational waves from super massive black hole binaries. These effects (signals) can manifest as a low-frequency fluctuation over time, phenomenologically similar to a red noise, while the remaining pulsar intrinsic and instrumental background (noise) are white. This article focuses on the frequency metrology of pulsars. From our standpoint, the pulsar is an accurate clock, to be measured simultaneously with several telescopes in order to reject the uncorrelated white noise. We apply the modern statistical methods of time-and-frequency metrology to simulated pulsar data, and we show the detection limit of the correlated red noise signal between telescopes.
On the absence of backsplash analogues to NGC 3109 in the ΛCDM framework
Authors: Banik Indranil , Haslbauer Moritz , Pawlowski Marcel S , Famaey Benoit , Kroupa Pavel 
Published: March 2021

ABSTRACT
The dwarf galaxy NGC 3109 is receding 105 km s−1 faster than expected in a Lambda cold dark matter (ΛCDM) timing argument analysis of the Local Group and external galaxy groups within 8 Mpc. If this few-body model accurately represents long-range interactions in ΛCDM, this high velocity suggests that NGC 3109 is a backsplash galaxy that was once within the virial radius of the Milky Way and was slingshot out of it. Here, we use the Illustris TNG300 cosmological hydrodynamical simulation and its merger tree to identify backsplash galaxies. We find that backsplashers as massive (≥4.0 × 1010 M⊙) and distant (≥1.2 Mpc) as NGC 3109 are extremely rare, with none having also gained energy during the interaction with their previous host. This is likely due to dynamical friction. Since we identified 13 225 host galaxies similar to the Milky Way or M31, we conclude that postulating NGC 3109 to be a backsplash galaxy causes &gt;3.96σ tension with the expected distribution of backsplashers in ΛCDM. We show that the dark matter only version of TNG300 yields much the same result, demonstrating its robustness to how the baryonic physics is modelled. If instead NGC 3109 is not a backsplasher, consistency with ΛCDM would require the 3D timing argument analysis to be off by 105 km s−1 for this rather isolated dwarf, which we argue is unlikely. We discuss a possible alternative scenario for NGC 3109 and the Local Group satellite planes in the context of MOND, where the Milky Way and M31 had a past close flyby 7–10 Gyr ago.
Mapping Global Neurosurgery Research Collaboratives: A Social Network Analysis of the 50 Most Cited Global Neurosurgery Articles
Authors: Kanmounye Ulrick Sidney , Sebopelo Lorraine Arabang , Keke Chiuyu , Zolo Yvan , Senyuy Wah Praise , Endalle Genevieve , Takoukam Régis , Sichimba Dawin , Nguembu Stéphane , Ghomsi Nathalie 
Published: March 2021

ABSTRACT
Social network analysis of bibliometric data evaluates the relationships between the articles, authors, and themes of a research niche. The network can be visualized as maps composed of nodes and links. This study aimed to identify and evaluate the relationships between articles, authors, and keywords in global neurosurgery. The authors searched global neurosurgery articles on the Web of Science database from inception to June 18, 2020. The 50 most cited articles were selected and their metadata (document coupling, co-authorship, and co-occurrence) was exported. The metadata were analyzed and visualized with VOSViewer (Centre for Science and Technology Studies, Leiden University, The Netherlands). The articles were published between 1995 and 2020 and they had a median of 4.0 (interquartile range [IQR] = 5.0) citations. There were 5 clusters in the document coupling and 10 clusters in the co-authorship analysis. A total of 229 authors contributed to the articles and Kee B. Park contributed the most to articles (14 publications). Backward citation analysis was organized into 4 clusters and co-occurrence analysis into 7 clusters. The most common themes were pediatric neurosurgery, neurotrauma, and health system strengthening. The authors identified trends, contributors, and themes of highly cited global neurosurgery research. These findings can help establish collaborations and set the agenda in global neurosurgery research.