bluuebunny/crossref_metadata_2025_split huggingface dataset:
Venlafaxine prescription claims among insured women of reproductive age and pregnant women, 2011–2016
Authors: Summers April D. , Anderson Kayla N. , Ailes Elizabeth C. , Grosse Scott D. , Bobo William V. , Tepper Naomi K. , Reefhuis Jennita 
Published: April 2021

AbstractBackgroundSome studies have reported associations between prenatal use of venlafaxine, a serotonin‐norepinephrine reuptake inhibitor used for depressive and anxiety disorders, and some birth defects. We described the prevalence of venlafaxine prescription claims among privately insured women of reproductive age and pregnant women.MethodsVenlafaxine prescription claims were examined using the IBM MarketScan Commercial Databases. We included women of reproductive age (15–44 years) who had ≤45 days of lapsed enrollment during the calendar year of interest (2011–2016) in a non‐capitated healthcare plan sponsored by a large, self‐insured employer with prescription drug coverage and no mental health service carve‐out. Annual cohorts of pregnant women were identified among eligible women of reproductive age via pregnancy diagnosis and procedure codes. Venlafaxine prescriptions were identified via National Drug Codes in outpatient pharmacy claims and we estimated the annual proportion of women with venlafaxine claims by pregnancy trimester (pregnant women only), age, and Census division.ResultsEach year during 2011–2016, approximately 1.2% of eligible reproductive‐aged and 0.3% of eligible pregnant women filled a venlafaxine prescription. Among pregnant women, the proportion with venlafaxine claims was highest during the first trimester and decreased during the second and third trimesters. Small temporal increases in venlafaxine claims were observed for reproductive‐aged and pregnant women, with the largest among women aged 15–19 years.ConclusionsVenlafaxine prescription claims were low among women of reproductive age and pregnant women during 2011–2016, with some increasing use over time among women aged 15–19 years.
Heart valve sizing and clinical outcomes in patients undergoing transcatheter aortic valve implantation
Authors: Okuno Taishi , Heg Dik , Lanz Jonas , Praz Fabien , Gräni Christoph , Langhammer Bettina , Reineke David , Räber Lorenz , Wenaweser Peter , Pilgrim Thomas , Windecker Stephan , Stortecky Stefan 
Published: April 2021

AbstractObjectivesTo investigate the impact of transcatheter heart valve (THV) sizing on procedural results and clinical outcomes following transcatheter aortic valve implantation (TAVI).BackgroundThe impact of individual THV sizing for patients with borderline aortic annulus anatomy remains unclear.MethodsIn the prospective BernTAVI registry, THV sizing conditions were retrospectively evaluated, and patients were categorized into three groups based on the recommendations and the sizing chart of the manufacturers: optimal sizing, borderline sizing (THV size located within 5% to each border of the optimal sizing recommendation), and suboptimal sizing (THV size outside the recommended range). The latter two groups were further subcategorized into THV‐oversizing and THV‐undersizing. The primary endpoint was a composite of all‐cause death and unplanned repeat intervention at 1 year.ResultsOut of a total of 1,638 patients who underwent TAVI, 9.5 and 15.6% of patients were categorized into the borderline and suboptimal sizing group, respectively. Device success was achieved in 87.4, 88.9, and 83.6% of patients with optimal, borderline, and suboptimal sizing, respectively. The primary endpoint occurred in 12.3% of patients with optimal sizing, 14.9% of patients with borderline sizing (HRadj 1.35, 95%CI 0.87–2.09), and in 17.4% of patients with suboptimal sizing (HRadj 1.42, 95%CI 1.01–1.99). Within the suboptimal sizing cohort, unfavorable outcomes were mainly associated with THV undersizing (device success: 76.4%, primary endpoint: 23.9%, HRadj 1.98, 95%CI 1.36–2.87).ConclusionSuboptimal TAVI prosthesis sizing is associated with an increased risk of all‐cause death and unplanned repeat intervention within 1 year largely attributable to undersized THV prostheses.
Development and in vitro Profiling of Dual FXR/LTA4H Modulators
Authors: Schierle Simone , Brunst Steffen , Helmstädter Moritz , Ebert Roland , Kramer Jan S. , Steinhilber Dieter , Proschak Ewgenij , Merk Daniel 
Published: April 2021

AbstractDesigned polypharmacology presents as an attractive strategy to increase therapeutic efficacy in multi‐factorial diseases by a directed modulation of multiple involved targets with a single molecule. Such an approach appears particularly suitable in non‐alcoholic steatohepatitis (NASH) which involves hepatic steatosis, inflammation and fibrosis as pathological hallmarks. Among various potential pharmacodynamic mechanisms, activation of the farnesoid X receptor (FXRa) and inhibition of leukotriene A4 hydrolase (LTA4Hi) hold promise to counteract NASH according to preclinical and clinical observations. We have developed dual FXR/LTA4H modulators as pharmacological tools, enabling evaluation of this polypharmacology concept to treat NASH and related pathologies. The optimized FXRa/LTA4Hi exhibits well‐balanced dual activity on the intended targets with sub‐micromolar potency and is highly selective over related nuclear receptors and enzymes rendering it suitable as tool to probe synergies of dual FXR/LTA4H targeting.
6‐Methyl‐7‐Aryl‐7‐Deazapurine Nucleosides as Anti‐Trypanosoma cruzi Agents: Structure‐Activity Relationship and in vivo Efficacy
Authors: Lin Cai , Ferreira de Almeida Fiuza Ludmila , Cardoso Santos Camila , Ferreira Nunes Daniela , Cruz Moreira Otacílio , Bouton Jakob , Karalic Izet , Maes Louis , Caljon Guy , Hulpia Fabian , de Nazaré C. Soeiro Maria , Van Calenbergh Serge 
Published: April 2021

AbstractChagas disease is a tropical infectious disease resulting in progressive organ‐damage and currently lacks efficient treatment and vaccine options. The causative pathogen, Trypanosoma cruzi, requires uptake and processing of preformed purines from the host because it cannot synthesize these de novo, instigating the evaluation of modified purine nucleosides as potential trypanocides. By modifying the pyrimidine part of a previously identified 7‐aryl‐7‐deazapurine nucleoside, we found that substitution of a 6‐methyl for a 6‐amino group allows retaining T. cruzi amastigote growth inhibitory activity but confers improved selectivity towards mammalian cells. By keeping the 6‐methyl group unaltered, and introducing different 7‐aryl groups, we identified several analogues with sub‐micromolar antitrypanosomal activity. The 7‐(4‐chlorophenyl) analogue 14, which was stable in microsomes, was evaluated in an acute mouse model. Oral administration of 25 mg/kg b.i.d. suppressed peak parasitemia and protected mice from infection‐related mortality, gave similar reductions as the reference drug of blood parasite loads determined by qPCR, but as benznidazole failed to induce sterile cure in the short time period of drug exposure (5 days).
Relationship between metabolic toxicity and efficacy of everolimus in patients with neuroendocrine tumors: A pooled analysis from the randomized, phase 3 RADIANT‐3 and RADIANT‐4 trials
Authors: Fazio Nicola , Carnaghi Carlo , Buzzoni Roberto , Valle Juan W. , Herbst Fabian , Ridolfi Antonia , Strosberg Jonathan , Kulke Matthew H. , Pavel Marianne E. , Yao James C. 
Published: April 2021

BACKGROUNDHyperglycemia and hypercholesterolemia are class effects of mammalian target of rapamycin inhibitors such as everolimus. This post hoc pooled analysis assessed the potential impact of these events on the efficacy of everolimus.METHODSPatients with advanced, low‐ or intermediate‐grade pancreatic, gastrointestinal, or lung neuroendocrine tumors received either oral everolimus at 10 mg/d or a placebo in the RAD001 in Advanced Neuroendocrine Tumors 3 (RADIANT‐3) and RAD001 in Advanced Neuroendocrine Tumors 4 (RADIANT‐4) trials. A landmark progression‐free survival (PFS) analysis by central review was performed for patients treated for at least 16 weeks (n = 308) and according to the occurrence of any‐grade adverse events (AEs) within this treatment period.RESULTSThe overall PFS with everolimus from the pooled analysis was 11.4 months (95% confidence interval, 11.01‐13.93 months), which was consistent with the findings of RADIANT‐3 and RADIANT‐4. Overall, 19.1% and 9.8% of patients in RADIANT‐3 and 11.9% and 6.4% of patients in RADIANT‐4 developed any‐grade hyperglycemia and hypercholesterolemia, respectively (regardless of the study drug). The duration of everolimus exposure was longer in patients who developed these AEs versus patients without these AEs. Overall, 308 patients were exposed to treatment for at least 16 weeks (hyperglycemia, 39 of 269 patients; hypercholesterolemia, 20 of 288 patients). No association was observed between the development of these AEs and PFS (18.8 and 14.1 months with and without hyperglycemia, respectively, and 14.1 and 14.8 months with and without hypercholesterolemia, respectively).CONCLUSIONSAlthough limitations apply because of the small number of AEs observed, there was no significant impact of these AEs on PFS; this suggests similar efficacy in the presence or absence of these events.
Quantitative analysis of endotoxin‐induced inflammation in human lung cells by Chipcytometry
Authors: Carstensen Saskia , Holz Olaf , Hohlfeld Jens M. , Müller Meike 
Published: April 2021

AbstractChipcytometry is a tool that uses iterative staining cycles with multiple antibodies for a detailed characterization of cells. Cell recognition is based on morphological features. Cells fixed on microfluidic chips can be stored and shipped enabling a centralized analysis, which is important for assessments in multi‐center clinical trials. The method was initially implemented for the analysis of cells from peripheral blood. We adapted it to more heterogeneous human lung cells from bronchoalveolar lavage (BAL) fluid and induced sputum (IS). We aimed to assess the performance of Chipcytometry to detect and quantify the endotoxin induced inflammatory response in healthy subjects. BAL and IS samples of 10 healthy subjects were collected prior to and following segmental and inhaled endotoxin challenge. Samples were analyzed by Chipcytometry and were compared with flow cytometry, and differential cell count (DCC). Chipcytometry clearly detected the endotoxin induced inflammatory response which was characterized by a massive increase of neutrophils (BAL: 2.5% to 54.7%; IS: 40.5% to 71.1%) and monocytes (BAL: 7.7% to 24.7%; IS: 8.0% to 14.5%). While some differences between detection methods exist, the overall results were comparable. The ability of Chipcytometry to verify fluorescent signals with morphological features improved the precision of rare cell analysis such as of induced sputum lymphocytes. In conclusion, Chipcytometry enables the quantitative analysis of cells from BAL fluid and IS. Advantages over DCC and flow cytometry include the storage of cells on chips, the ability for re‐analysis and the mapping of surface marker binding to morphological information. It therefore appears to be a promising method for use in clinical respiratory drug development.
Precision agriculture with cluster‐based optimal routing in wireless sensor network
Authors: Agarkhed Jayashree , Dattatraya Patil Yogita , Patil Siddarama 
Published: April 2021

SummaryAgriculture played a vital role in the growth of the Indian economy. New technologies can overcome the various issues in agriculture. One such ever‐growing area is Precision Agriculture (PA) with advancements in Wireless Sensor Network (WSN) technology. It finds applications in various segments of agriculture. The data packet of each application expects different services from the underlying network. Most of the techniques have not found much on service differentiation and arrival rate. Due to the dynamicity of the network, the traffic rate may get vary and load the selected paths which degrade performance expected from the network. These issues addressed by the proposed protocol employing Decision Support System (DSS) for intelligent path selection based on traffic rate. The proposed protocol outperforms in terms of minimized delay, energy consumption, achieving high throughput, and packet delivery ratio.
Fathers’ oxytocin responses to first holding their newborns: Interactions with testosterone reactivity to predict later parenting behavior and father‐infant bonds
Authors: Gettler Lee T. , Kuo Patty X. , Sarma Mallika S. , Trumble Benjamin C. , Burke Lefever Jennifer E. , Braungart‐Rieker Julia M. 
Published: April 2021

AbstractLittle is known about human fathers’ physiology near infants’ births. This may represent a period during which paternal psychobiological axes are sensitive to fathers’ new experiences of interacting with their newborns and that can provide insights on how individual differences in fathers’ biology relate to post‐partum parenting. Drawing on a sample of men in South Bend, IN (U.S.), we report results from a longitudinal study of fathers’ oxytocin, cortisol, and testosterone (N = 211) responses to their first holding of their infants on the day of birth and men's reported caregiving and father‐infant bonding at 2–4 months post‐partum (N = 114). First‐time fathers’ oxytocin was higher following first holding of their newborns, compared to their pre‐holding levels. Contrasting with prior results, fathers’ percentage change in oxytocin did not differ based on skin‐to‐skin or standard holding. Drawing on psychobiological frameworks, we modeled the interactions for oxytocin reactivity with testosterone and cortisol reactivity, respectively, in predicting father‐infant outcomes months later. We found significant cross‐over interactions for (oxytocin × testosterone) in predicting fathers’ later post‐partum involvement and bonding. Specifically, we found that fathers whose testosterone declined during holding reported greater post‐partum play if their oxytocin increased, compared to fathers who experienced increases in both hormones. We also observed a similar non‐significant interaction for (oxytocin × cortisol) in predicting fathers’ post‐partum play. Fathers whose testosterone declined during holding also reported less involvement in direct caregiving and lower father‐infant bonding if their oxytocin decreased but greater direct care and bonding if their testosterone increased and oxytocin decreased. The results inform our understanding of the developmental time course of men's physiological responsiveness to father‐infant interaction and its relevance to later fathering behavior and family relationships.
Towards faster big data analytics for anti‐jamming applications in vehicular ad‐hoc network
Authors: Bangui Hind , Ge Mouzhi , Buhnova Barbora , Hong Trang Le 
Published: April 2021

AbstractNowadays, Wireless Vehicular Ad‐Hoc Network (VANET) has become a valuable asset for transportation systems. However, this advanced technology is characterized by highly distributed and networked environment, which makes VANET communications vulnerable to malicious jamming attacks. Although Big Data Analytics has been used to solve this critical security issue by supporting the development of anti‐jamming applications, as the amount of vehicular data is growing exponentially, the anti‐jamming applications face many challenges (i., reactions in real‐time) due to the lack of specific solutions that can keep up with the fast advancement of VANET. In this paper, we propose a new vehicular data prioritization model based on coresets to accelerate the Big Data Analytics in VANET. Our experimental evaluation shows that our solution can significantly increase the efficiency for clustering in jamming detection while keeping and improving the clustering quality. Also, the proposed solution can enable the real‐time detection and be integrated to anti‐jamming applications.
Effect of the corrugated bipolar plate design on the self‐humidification of a high power density PEMFC stack for UAVs
Authors: Nefedkin Sergey I. , Klimova Mariya A. , Glasov Vasiliy S. , Pavlov Vladislav I. , Tolmachev Yuriy V. 
Published: April 2021

AbstractOpen‐cathode PEMFCs for unmanned aerial vehicles operate at a near‐ambient temperature, which requires high super‐stoichiometric air flow rates to remove heat. This, in turn, makes the stack vulnerable to drying out. Using a combination of experimental measurements with a 1.2 kW stack and 3D multiphysics modelling, we show that the design of the corrugated metal bipolar plate with a height above the commonly used 1.05 mm and with cathode cooling channels wider than air‐suppling channels allows for a more efficient heat removal at lower air flow rates, thus assuring a wider range of operating parameters, while maintaining adequate hydration. The self‐humidifying stack attains 1000 W kg−1 power, and the full system with a nominal runtime of 4 h attains specific energy of 700 Wh kg−1.
Association of social deprivation with cognitive status and decline in older adults
Authors: Hofbauer Lena M. , Rodriguez Francisca S. 
Published: April 2021

AbstractObjectivesSocial deprivation, i.e. the relative deprivation in socioeconomic domains, is known to exacerbate disease risk. Less is known about its role in cognitive functioning and decline in older adults. This study aimed to investigate the association between social deprivation and cognitive status as well as rate of decline.MethodsWe analysed data from the nationally representative Health and Retirement study (HRS) of individuals aged 50 and older. The analysis sample contained 11,101 respondents (mean age at baseline: 69.4, SD: 8.6%, 55% female) with at least two cognitive assessments (mean follow up: 11.2, SD: 5.4). To quantify social deprivation we constructed a social deprivation index (SDI) with structural equation modelling. Multiple growth curve modelling was used to model cognitive status and decline as predicted by SDI.ResultsAfter adjusting for covariates, greater social deprivation was associated with poorer cognitive status (β = −0.910, p < 0.001; 95% CI: −0.998–0.823) and faster cognitive decline (β = −0.005, p = 0.002; 95% CI:−0.009–0.002). Of the covariates, depressive symptoms, chronic disease burden, belonging to a racial or ethnical minority, and male gender were also associated with poorer cognitive status. Marriage statuses other than being married or partnered had a positive association with cognitive status.ConclusionsOur findings indicate that greater social deprivation was associated with significantly poorer cognitive status implying that preventing social deprivation can contribute to raising cognitive functioning in the older population and help reduce the incidence of dementia. Policy that facilitates early intervention in social deprivation will be key.
Assessment of groundwater quality for irrigation and drinking using different quality indices and geostatistical methods in Çorum province (Turkey)*
Authors: Şahin Kiy Makbule , Arslan Hakan 
Published: April 2021

AbstractGroundwater is widely used for irrigation and drinking purposes. Therefore, assessing groundwater quality is very important for sustainable agricultural irrigation and human welfare. In this study, different water quality indices including electrical conductivity (EC), sodium adsorption ratio, permeability index, sodium percentage, Langelier saturation index, residual sodium carbonate, magnesium ratio (MR), Kelly index (KI), potential salinity (PS), and irrigation water quality index (IWQI) were evaluated to determine the suitability for irrigation. The drinking water quality index (DWQI) was used to assess the suitability for drinking purposes. Spatial distribution maps were created by the ordinary kriging method, using the best semivariogram model parameters for each quality index. The Gaussian model gave the best results for all parameters except for MR and PS. Results from the study area showed that 86.1% of EC, 15.4% of KI, and 52.1% of MR were unsuitable for irrigation purposes, and none of the wells were fit for drip irrigation. The IWQI value was above 70 in 51.2% of this area, which is suitable for irrigation of all plants, whereas it was determined that about 13% of all areas are unsuitable for drinking purposes with regard to DWQI.
Stabilization of group 14 elements E = C, Si, Ge byhetero‐bilepticligandscAAC,MCOnwithpush‐pullmechanism
Authors: Gorantla Sai Manoj N. V. T. , Parameswaran Pattiyil , Mondal Kartik Chandra 
Published: April 2021

AbstractThe stability and bonding of a series of hetero‐diatomic molecules with general formula (cAAC)EM(CO)n, where cAAC = cyclic alkyl(amino) carbene; E = group 14 elements (C, Si, and Ge); M = transition metal (Ni, Fe, and Cr) have been studied by quantum chemical calculations using density functional theory (DFT) and energy decomposition analysis‐natural orbital chemical valence (EDA‐NOCV). The equilibrium geometries were calculated at the BP86/def2‐TZVPP level of theory. The tri‐coordinated group 14 complex (1a,4a, and7a) in which one of the CO groups is migrated to the central group 14 element from adjacent metal is theoretically found to be more stable when the central atom (E) is carbon. On the other hand, the two‐coordinate group 14 element containing metal‐complexes (2,5,8,3,6, and9) are found to be more stable with their corresponding heavier analogues. The electronic structures of all the molecules have been analyzed by molecular orbital, topological analysis of electron density and natural bond orbital (NBO) analysis at the M06/def2‐TZVPP//BP86/def2‐TZVPP level of theory. The nature of the cAACE and EM bonds has been studied by EDA‐NOCV calculations at BP86‐D3(BJ)/TZ2P level of theory. The EDA analysis suggests that the bonding of cAACC(CO) can be best represented by electron sharing σ and π interactions, whereas, C(CO)M(CO)n−1by dative σ and π interactions. On the other hand, EDA‐NOCV calculations suggests both dative σ and π interactions for cAACE and EM(CO)nbonds of the corresponding Si and Ge analogues having stronger σ‐ and relatively weaker π‐bonds. The topological analysis of electron density supports the closed‐shell interaction for the Si and Ge complexes and open‐shell interaction for the carbon complexes. The calculated proton affinity and hydride affinity values corroborated well with the present bonding description. This class of complexes might act as efficient future catalysts for different organic transformations due to the presence of electron rich group 14 element and metal carbonyl.