bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of lncRNA FOXD2-AS1 expression as a diagnostic biomarker in CRC
Authors: Shalmashi Hooman , Safaie Sahar , Shanehbandi Dariush , Asadi Milad , Bornehdeli Soghra , Navaz Abdolreza Mehdi 
Published: September 2021

Abstract
Background

Colorectal cancer (CRC) is still considered one of the prevalent cancers worldwide. Investigation of potential biomarkers for early detection of CRC is essential for the effective management of patients using therapeutic strategies. Considering that, this study was aimed to examine the changes in lncRNA FOXD2-AS1 expression through colorectal tumorigenesis.
Material and Methods

Fifty CRC tumor tissues and fifty adjacent normal tissue samples were prepared and involved in the current study. Total RNA was extracted from the samples and then reverse transcribed to complementary DNA. Next, the expression levels of lncRNA FOXD2-AS1 were evaluated using real-time PCR in CRC samples compared to normal ones. Also, receiver operating characteristic curve (ROC) analysis was used to evaluate the diagnostic value of FOXD2-AS1 for CRC.
Results

The obtained results showed that the expression level of FOXD2-AS1 gene was significantly (p < 0.0001) up-regulated in tumor tissues compared to normal marginal tissues. Also, a significant correlation was observed between higher the expression of FOXD2-AS1and the differentiation of tumor cells. Furthermore, ROC curve analysis estimated an AUC value of 0.59 for FOXD2-AS1, suggesting its potential as a diagnostic target.
Conclusion

Taken together, the current study implied that tissue-specific upregulation of lncRNA FOXD2-AS1 might be appropriate diagnostic biomarkers for CRC. Nonetheless, m studies are needed to validate these results and further illustrate FOXD2-AS1 function through colorectal tumorigenesis.
Optimization of the qPCR temperature profile is essential for efficient and rapid detection of Sars-CoV-2
Authors: Salamon Pál , Bálint Emese , Tar Gyöngyi , Albert Beáta 
Published: September 2021

Abstract
qPCR protocols should specify shorter annealing and extension times to optimize the efficacy of the target product. These specific times must be long enough for the complexes to form at the correct binding site, but if these times are too long, it can result in unspecified products. Our results show that reducing the reaction time during the second cycle can increase the specificity of the resulting product and thus reduce the total reaction time. The overall temperature profile, optimized for the target gene, shortens the detection time, allowing faster and more specific detection of the presence of the Sars-CoV-2.
Electricity consumption of drying and the effect of the dryer and temperature on the chemical quality of nettle leaves (Urtica dioica L.), birch leaves (Betula pendula, Betula pubescens) and roseroot (Rhodiola rosea L.)
Authors: Isosaari Eveliina , Väisänen Jaana , Favén Leena 
Published: September 2021

Abstract
Drying can constitute the majority of the energy costs and thus, manufacturing costs, in plant refining. The use of higher drying temperatures accelerates drying and reduces total electricity consumption. However, higher drying temperatures can also reduce the chemical quality of plants, as heat sensitive compounds can degrade or evaporate. The purpose of the study was to find the optimum drying temperature for nettle leaves (Urtica dioica L.), white and silver birch leaves (Betula pubescens, Betula pendula) and roseroot (Rhodiola rosea L.) in terms of electricity consumption and quality. Selected plants were dried with drying oven, convective dryer and vacuum dryer between 40 and 80 °C. The quality was determined by measuring total polyphenol content, antioxidant capacity and active compounds of roseroot. The lowest total electricity consumption was obtained by drying oven, but the highest chemical quality was obtained by vacuum dryer. The optimum drying temperature varied between 65 and 80 °C.
Graphene spin-coated electrode for polyacrylonitrile acoustic nanogenerators
Authors: Aghayari Sedigheh 
Published: September 2021

Abstract
In recent years piezoelectric nanogenerators, due to their more durability in high dust or humidity are more attractive than triboelectric ones. So, increasing their outputs is the subject of much researches. I focused on electrodes of the acoustic nanofibers nanogenerators for the first time. Here, I introduced a new electrode that is cheaper and does not result in lower outputs. Here for the first time graphene spin-coated ink was used for polyacrylonitrile-based acoustic nanogenerator. The results of the tests compared with the in-situ synthesis of nickel nanoparticles on the layer and using graphene spin-coated screen ink and conductive tapes. Finally, producing sound by this graphene ink was done too.
Selected ‘Starter Kit’ energy system modelling data for Peru (#CCG)
Authors: Cannone Carla , Allington Lucy , Pappis Ioannis , Barron Karla Cervantes , Usher Will , Pye Steve , Howells Mark , Walker Miriam Zachau , Ahsan Aniq , Charbonnier Flora , Halloran Claire , Hirmer Stephanie , Taliotis Constantinos , Sundin Caroline , Sridha Vignesh , Ramos Eunice , Brinkerink Maarten , Deane Paul , Gritsevskyi Andrii , Moura Gustavo , Rouget Arnaud , Rogner Holger , Quirós-Tortós Jairo , Angulo-Paniagua Jam 
Published: September 2021

Abstract
Energy system modelling can be used to assess the implications of different scenarios and support improved policymaking. However, access to data is often a barrier to energy system modelling, causing delays. Therefore, this article provides data that can be used to create a simple zero order energy system model for Peru, which can act as a starting point for further model development and scenario analysis. The data are collected entirely from publicly available and accessible sources, including the websites and databases of international organizations, journal articles, and existing modelling studies. This means that the dataset can be easily updated based on the latest available information or more detailed and accurate local data. These data were also used to calibrate a simple energy system model using the Open Source Energy Modelling System (OSeMOSYS) and two stylized scenarios (Fossil Future and Least Cost) for 2020–2050. The assumptions used and results of these scenarios are presented in the appendix as an illustrative example of what can be done with these data. This simple model can be adapted and further developed by in-country analysts and academics, providing a platform for future work.
Analysis of long-term climatic changes at Hodeidah-Yemen during the period between 1984 and 2019
Authors: Iraqi Abkar Ali , AbdAlla AbdAlla Mohammed 
Published: September 2021

Abstract
Yemen is one of the Arab country that is vulnerable to climate changes, and this is clear from the indicators of impact on water resources, coastal zone environments, etc. This work focuses on studying the climatic variability at Hodeidah city-Yemen during the period between 1984 and 2019. This study aimed to characterize trends in mean monthly, seasonal and annual temperature. To attain these objectives the collected data were analyzed using both parametric (linear regression) and non-parametric (Mann–Kendall, Spearman and Sen's slope estimator tests) methods to detect the trend and the magnitudes of rates of changes of temperature over time. Analysis of data indicates clear climatic fluctuations of temperature. The annual means of temperature during the period of study were varied between 26.9°C and 30.1°C. The warmest years were observed during the more recent years of the study period ( 2005 to 2018). The increasing rate of annual temperature is about + 0.075°C /year, + 0.37°C/5year, + 0.75°C/decade ,+2.53°C, over the whole period of study(1985 to 2019), + 3.7°C/50 year and increase to + 4.85°C in 2050. On a monthly timescale, there are similar magnitudes of rates of change from December to September with highest rates in October and November. The results also showed that most months and seasons have significant positive trends in temperature and (Z-α/2) values of the MK Test > 1.96 and positive value of Sen’s slope estimator indicates significant an increasing trend towards warmer years. Anomalies of temperature confirm significant increasing trends towards warmer years (2000s to 2019).
Complicated Meckel’s Diverticulum: lessons learnt from a case series of a single institution.
Authors: Duci Miriam , Codrich Daniela , Boscarelli Alessandro , Guida Edoardo , Miglietta Marta , Scarpa Maria-Grazia , Olenik Damiana , Leo Grazia Di , Murru Flora-Maria , Schleef Jurgen 
Published: September 2021

Abstract
The aim of our study is to share a single pediatric institution’s experience with complicated Meckel’s diverticulum. The clinical records of a series of 15 cases treated between January 2006 and December 2020 were reviewed. Patients were divided according to the presenting symptoms (obstructive versus painful bleeding) and subcategorised according to demographic details, intraoperative findings, surgical technique, histological examination and length of stay. Patients older than 17 years of age were excluded from the study. Males were more prone to present with complicated Meckel’s diverticulum than females, and obstructive symptoms were the most frequent presentation (60%). Median age at presentation was 9 years. The surgical technique of choice was an explorative laparoscopy in 12 cases, even though 25% of patients required conversion to laparotomy. There was no statistically significant difference between groups in terms of length of stay. Results are discussed with reference to current literature.
Employee Turnover and Job Satisfaction: A synthesis of Factors influencing employee turnover in Institutions of Higher Learning in Ghana
Authors: Mumin Alhassan Abdul , Achanso Adams Sulemana , Mordzeh-Ekpampo Musah Ibrahim , Boasu BismarkYeboah , Dei David 
Published: September 2021

Abstract
Turnover among teaching staff in our universities are mostly due to dissatisfaction with their jobs. Employee job satisfaction is of utmost importance to stimulating and sustaining the interest of the individual in order to prevent employee turnover. There are many factors influencing employee job satisfaction and preventing employee turnover. Factors such as salary, working conditions, cordial relationship with colleagues at work, opportunities for job progression among several other factors. The objective of this paper was to explore the extent to which these factors, affect employee job satisfaction and prevent turnover among lecturers in the University for Development Studies using the cross-sectional design and quantitative approach of data collection. Survey questionnaires were employed as data collection instruments to elicit information from 287 lecturers recruited from the University for Development Studies within the Tamale Metropolis. Multiple regression was used to establish the effect factors influencing job satisfaction had on employee turnover. Major findings from the study alluded to the fact that salary, working conditions, working environments, carrier advancement, relationship with co-workers have significant correlation with job satisfaction and employee turnover of lecturers in this institution. On account of these findings, this paper suggests yearly salary adjustments, creates a conducive working environment for lecturers, improve upon infrastructural facilities and facilitates carrier advancement issues for lecturers so as to prevent them from exiting the institution.
Biological sulfate removal with low-cost carbon sources using cold-acclimated bacteria
Authors: Virpiranta Hanna , Taskila Sanna , Leiviskä Tiina , Vepsäläinen Jouko , Rämö Jaakko , Tanskanen Juha 
Published: September 2021

Abstract
The main goal of this study was to develop a cost-efficient biological method for the removal of sulfate from mining effluents in cold conditions. A consortium of cold-tolerant sulfate-reducing bacteria (SRB) was tested at 6 °C regarding the utilization of economically viable, low-cost carbon sources, i.e., whey, conditioned sewage sludge, and peat, in the removal of sulfate from synthetic mining water. Succinate was used as a reference carbon source. Of all the studied low-cost carbon sources, conditioned sewage sludge proved to be the most efficient. Nuclear magnetic resonance (NMR) spectroscopy revealed that sewage sludge contained propionic acid, which proved to be utilizable by SRB under cold conditions. Peat both adsorbed the sulfate and acted as a nutrient source in the sulfate reduction process. When whey was used as a carbon source, only a slight decrease in sulfate concentration was detected. Succinate was found to work in a truly predictable and efficient way as a carbon source in biological sulfate reduction, even at the lowest concentration tested. The use of conditioned sewage sludge increased the bacterial diversity in liquid cultivations significantly. However, the number of SRB was highest in the succinate cultivations.
Justice and sanitation well-being: an analysis of frameworks in the context of slippage, based on findings from Shravasti, Uttar Pradesh, India
Authors: Khare Kopal , Suresh Lavanya 
Published: September 2021

Abstract
Access to safe drinking water and adequate sanitation is considered as a basic human right. Swachh Bharat Mission – Gramin (Rural), launched by the Government of India in 2014, is hailed as an attempt towards that direction. On 2nd October 2019, India was declared free from open defecation, with rural households having full toilet coverage. However, despite Government claims, the existing literature indicates the presence of slippage: where households practice open defecation despite having access to toilets. Equating progress in sanitation interventions with mere toilet provision presents a partial assessment of sanitation. To address the gap, the ‘Sanitation Well-being’ framework, based on Amartya Sen's concept of justice, has been proposed. It identifies slippage as an outcome of various underlying factors across the sanitation life-cycle. The framework provides a lens to analyse existing frameworks and secondary data sets and finds that they do not capture the dynamism inherent in the sector. The efficacy of the framework has been tested in the rural district of Shravasti, Uttar Pradesh, India, through the rapid rural appraisal method. Through our investigation, we found that slippage exists in the field, and that the framework is a feasible instrument to assess sanitation as a comprehensive phenomenon.
Removing free-floating oil from water using cationic polymers/surfactant-modified silica
Authors: Ruksanti Anucha , Janhom Sorapong 
Published: September 2021

Abstract
The purpose of this work was to evaluate the efficiency of oil sorption of silica particles modified by three different types of cationic polymers and a cationic surfactant. Low-molecular-weight polyethyleneimine (LPEI), high-molecular-weight polyethyleneimine (HPEI), polydiallyldimethylammonium chloride (PDM), and cetyltrimethylammonium bromide (CTAB) were used to modify the silica particles and then compared their performances for oil removal. The scanning electron microscope and zeta potential measurements were used to analyze the surface characteristics of unmodified and modified silica particles. Adsorptions of motor oil and palm oil on the modified silica particles have been investigated under various parameters such as the silica particle size, the oil concentration, the polymer/surfactant concentrations, and the pH. The results have shown that the modified silica particles enhanced the oil sorption ability by approximately 10–20 times depending on the size of silica particles, pH, and the type of polymer/surfactant used when compared with the unmodified silica particles. The highest palm oil adsorption values of LPEI-silica, HPEI-silica, PDM-silica, CTAB-silica, and unmodified silica were 2.40, 2.10, 1.95, 1.50, and 0.15 g/gsilica, respectively. Moreover, the oil sorption of the modified silica particles was increased by approximately 30–50% for the smallest-sized silica particles.
Using data mining methods to improve discharge coefficient prediction in Piano Key and Labyrinth weirs
Authors: Majedi-Asl Mahdi , Fuladipanah Mehdi , Arun Venkat , Tripathi Ravi Prakash 
Published: September 2021

Abstract
As a remarkable parameter, the discharge coefficient (Cd) plays an important role in determining weirs' passing capacity. In this research work, the support vector machine (SVM) and the gene expression programming (GEP) algorithms were assessed to predict Cd of piano key weir (PKW), rectangular labyrinth weir (RLW), and trapezoidal labyrinth weir (TLW) with gathered experimental data set. Using dimensional analysis, various combinations of hydraulic and geometric non-dimensional parameters were extracted to perform simulation. The superior model for the SVM and the GEP predictor for PKW, RLW, and TLW included , and respectively. The results showed that both algorithms are potential in predicting discharge coefficient, but the coefficient of determination (RMSE, R2, Cd(DDR)max) illustrated the superiority of the GEP performance over the SVM. The results of the sensitivity analysis determined the highest effective parameters for PKW, RLW, and TLW in predicting discharge coefficients are , , and Fr respectively.
Investigating the role of the morphology of the Zn-Al LDH on the adsorption of humic acid from aqueous solutions
Authors: Khoshalhan Davoudli Hamid , Saadat Solmaz , Rahsepar Mansour , Azadi Fatemeh 
Published: September 2021

Abstract
Flake Zn-Al layered double hydroxides (FLDHs) and microspheres of LDH (MLDHs) were fabricated with a simple hydrothermal method to investigate the role of the morphology of Zn-Al LDH for humic acid (HA) adsorption from synthetic solutions and natural water. The effect of process variables, i.e. contact time, initial concentration of HA, pH, and competitive ions on the adsorption was investigated. HA removal mechanism was also studied. The two adsorbents exhibited different adsorption behaviors for HA in the presence and absence of background ions, which may be highly correlated with the various adsorption mechanisms involved. Comparison of the HA removal capacity of these two adsorbents implies the superior adsorption capability of FLDH for removal of HA from synthetic solutions (9.5 mg/g), while the adsorption capacity of MLDH was higher for natural organic matters present in natural water samples containing co-existing ions (8.9 mg/g). The pseudo-second-order kinetics model and Longmuir isotherm model could adequately interpret the HA adsorption process for the studied adsorbents. Both LDHs exhibited good regeneration and recycling abilities.
PERFIL DE MORTALIDADE MATERNA NA ÚLTIMA DÉCADA (2010 – 2019) NO ESTADO DA BAHIA
Authors: Souto Figueiredo Nepomuceno Ana Flávia , Souto Figueiredo Mariana , Santos de Jesus Veríssimo , Oliveira dos Santos Liz 
Published: September 2021

Introdução: A mortalidade materna é um problema de saúde pública com elevada prevalência e que pode ser, na maioria dos casos, prevenida. As últimas décadas mostraram decréscimo nos índices, no entanto, nota-se que esse problema afeta principalmente regiões com maior vulnerabilidade social, dentre as quais destaca-se o nordeste brasileiro onde encontra-se o estado da Bahia. Objetivo: Analisar o perfil de mortalidade materna na última década no estado da Bahia. Metodologia: Trata-se de um estudo do tipo epidemiológico, transversal, retrospectivo e descritivo, tendo como base a análise secundária de informações disponíveis no Sistema de Informação sobre mortalidade (SIM) no período correspondente a 2010 a 2019 no estado da Bahia, Brasil. Resultados: No período estudado segundo o SIM, foram computados um total de 1313 óbitos maternos no estado da Bahia. A maioria das acometidas apresentava faixa etária de 30 a 39 anos (44,35%), com maior prevalência de pessoas não brancas (81,11%). Quanto à causa da morte, o estudo obteve predomínio de mortes por causas diretas (67,21%) que ocorreram de modo majoritário em ambiente hospitalar (90,17%). Conclusões: Observa-se por meio do presente estudo que a mortalidade materna na Bahia constitui-se como um importante agravo em saúde, o que demanda a elaboração de um conjunto de medidas a fim de garantir segurança às gestantes e puérperas do estado.
Palavras-Chave: Gravidez, Mortalidade Materna, Morte, Saúde da Mulher.
The Antioxidant Activity of Phenolic Compounds Isolated from the Bark
of Ryukyu Pine Trees (Pinus luchuensis Mayr.)
Authors: Takashi Hanagasaki , Shoei Teruya 
Published: September 2021

Background:
Considering that many foreign tourists visit Okinawa, Japan, to purchase
cosmetic products, there is an urgent need to create cosmetic products native to Okinawa. As the
Ryukyu pine tree, which is endemic to Okinawa, has been used as a source of wood, investigating
the possible use of its bark is recommended. Using this natural resource from Okinawa would aid
in promoting the products of Okinawa’s unique brands. As a result, this study was designed to isolate
useful materials for cosmetic production. Therefore, fractionation was conducted based on a
few types of chromatographies, after which the extracted product of the Ryukyu pine tree (Pinus
luchuensis Mayr.) bark was analyzed, and its polyphenol contents were compared.

Methods:
Bark of the Ryukyu pine tree cultivated in the northern mountainous region of the Okinawa
Main Island was used for ASE extraction using ultrapure water at 130°C. DIAION HP20
with methanol and two HPLC fractionation types were subsequently used for phenolic compound
isolation.

Results:
ASE extraction and HP20 and HPLC fractionations resulted in an isolation of several compounds:
threo-1,2-bis-(4-hydroxy-3-methoxyphenyl)-propane-1,3-diol (compound 1; 0.03% w/w
of an ASE extract), erythro-1,2-bis-(4-hydroxy-3-methoxyphenyl)-propane-1,3-diol (compound 2;
0.03% w/w of an ASE extract), catechin (0.11% w/w of an ASE extract), and vanillin (0.31% w/w
of an ASE extract). In addition, the value of its antioxidant activity determined by the DPPH (2,2-
diphenyl-1-picrylhydrazyl) radical-scavenging capacity assay was 3.3 mmol-trolox eq./g, 2.6
mmol-trolox eq./g, 9.7 mmol-trolox eq./g and 0.7 mmol-trolox eq./g for compound 1, compound 2,
catechin, and vanillic acid, respectively.

Conclusion:
These phenolic compounds possess whitening and anti-aging potentials. Therefore,
the Ryukyu pine tree bark would be a useful raw material source for cosmetic production.