bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanochips assisted peptide screening for clinical development of CAR-T cell immunotherapy
Authors: Nguyen-Le Trang Anh , Bartsch Tabea , Wodtke Robert , Brandt Florian , Arndt Claudia , Feldmann Anja , Bojorquez Diana Isabel Sandoval , Roig Arnau Perez , Ibarlucea Bergoi , Lee Seungho , Baek Chang-Ki , Cuniberti Gianaurelio , Bergmann Ralf , Puentes-Cala Edinson , Soto Javier Andrés , Kurien Biji T. , Bachmann Michael , Baraban Larysa 
Published: August 2021

Abstract
Immunotherapy using CAR-T cells is a new paradigm technology for cancer treatment. To avoid severe side effects and tumor escape variants observed for conventional CAR-T cells approach, adaptor CAR technologies are under development, where intermediate target modules redirect immune cells against cancer. In this work, silicon nanowire field effect transistors are used to assist in the development of target modules for an optimized CAR-T cell operation. Focusing on a library of seven variants of E5B9 peptide that is used as CAR peptide epitope, we performed multiplexed binding tests in serum using nanosensor chips. Peptides have been immobilized onto the sensor to compare the signals of transistor upon titration with anti-E5B9 antibodies. Correlation analysis of binding affinities and sensitivities enabled a selection of best candidates for the interaction between CAR and target modules. Finally, cytotoxic functionality of CAR-T cells in combination with the selected target modules were successfully proven. Our results open the perspective for the nanobiosensorics to go beyond the early diagnostics in the field of clinical cancer research, and paves the way towards personalization and efficient monitoring of the immunotherapeutic treatment, where the quantitative analysis with the standard techniques is not an option.
Mental Health, Partnerships, and Sexual Behavior of German Students After the Third Wave During the Corona Pandemic
Authors: Supke Max , Hahlweg Prof. Dr. Kurt , Kelani Krenare , Muschalla Prof. Dr. Beate , Schulz Prof. Dr. Wolfgang 
Published: August 2021

Abstract
Background. The corona pandemic has drastically changed students' lives and increased their perceived stress. At the end of winter and in spring 2021, Germany experienced the third wave of the pandemic. This study aims to examine the state of students’ mental health after the third wave as well as partnerships and sex life during the pandemic.
Methods. In June and July 2021, 928 students (mean age: 23.6; 63.5% females) from four universities in Germany completed an online survey. The PHQ-9 and GAD-7 were used to assess mood problems and worrying.
Results. Our results show that 56.4% were above the cut-off value for clinically relevant mood problems, 35.7% for worrying and 33.4% were above both cut-off values simultaneously (≥10). The female gender, higher study stress, low financial resources, higher strain due to corona and more loneliness were associated with severe symptoms, whereas higher life satisfaction, more sleep, and psychological/psychiatric treatment were related to better mental health. Students who started studying in the pandemic showed slightly more mood problems than longer enrolled students. The vast majority (89.3%) of all students were happy with their current relationship. While half of the students noted no change in their relationship, a quarter each reported improvement or deterioration. Every third single student has had less sex and in every fifth partnership it came to more sex during the pandemic.
Conclusion: Students´ mental health seems to be worse compared to pre-pandemic data and also compared to the first wave data, especially concerning mood problems (depressive symptoms). Women are significantly more burdened than men. It should be further investigated whether rates of symptom load will be lower again when universities reopen and study life becomes normal.
Greenland Ice Sheet runoff reduced by meltwater refreezing in bare ice
Authors: Cooper Matthew , Smith Laurence , Rennermalm Åsa , Yang Kang , Liston Glen , Ryan Jonathan , As Dirk van , Pitcher Lincoln , Miège Clément , Cooley Sarah , Overstreet Brandon 
Published: August 2021

Abstract
The Greenland Ice Sheet’s contribution to global sea-level rise is accelerating1 due to increased melting of its bare-ice ablation zone2–6, but there is growing evidence that climate models overestimate runoff from this critical area of the ice sheet7–12. Current climate models assume all bare ice runoff escapes to the ocean, unlike snow covered areas where some fraction of runoff is retained and/or refrozen in porous firn13–15. Here we use in situ measurements and numerical modeling to reveal extensive retention and refreezing of liquid meltwater in bare glacial ice, explaining chronic runoff overestimation by climate models. From 2009–2018, refreezing of liquid meltwater in bare, porous glacial ice reduced meltwater runoff by 11–23 Gt a-1 in southwest Greenland alone, equivalent to 10–20% of annual meltwater production. This mass retention is commensurate with current estimates of climate model ice sheet meltwater runoff uncertainty, and may represent an overlooked buffer on projected runoff increases for the coming century16. Inclusion of bare-ice retention and refreezing processes in climate models therefore has immediate potential to improve forecasts of ice sheet runoff and its contribution to global sea-level rise.
RedoxiFluor: A microplate assay to quantify protein thiol redox state in percentages and moles
Authors: Tuncay Ahmet , Noble Anna , Guille Matthew , Cobley James 
Published: August 2021

Abstract
An accessible, time- and cost-efficient microplate assay to quantify protein thiol redox state in percentages and moles relative to the thiol proteome (i.e., context) and other targets (i.e., array mode) would be invaluable for understanding how protein thiols regulate essential biological processes. RedoxiFluor achieves several key benefits (i.e., percentages, moles, context, array mode) in a microplate format. After robustly validating RedoxiFluor, comparative analysis reveals that key benefits are intractable to other immunological techniques. Moles is an unprecedented achievement. Proof-of-concept studies illuminating fundamental redox principles (i.e., specificity, context, and heterogeneity) through measurement alone demonstrate how RedoxiFluor can advance understanding. For example, target specific protein thiol redox state changes are: (1) context specific (i.e., redox stimulus dependent); (2) selective (i.e., redox stimuli oxidise select targets); and (3) heterogenous (i.e., target responses vary markedly). RedoxiFluor is a powerful new tool for advancing a far-reaching and influential field: protein thiol redox biology.
Biological Importance, Therapeutic Benefit, and Medicinal Importance of
Flavonoid, Cirsiliol for the Development of Remedies against Human Disorders
Authors: Patel Dinesh Kumar 
Published: August 2021

Background:
Phytochemicals are pure chemical compounds found to be present in different
plants part such as leaves, fruit, flower, seeds and the whole plant. These pure plant-based
chemicals are having power to treat all disorders of the human beings and other higher animal species
on earth. Flavonoidal compounds are responsible for the attractive color and important biological
properties of plant material. Flavonoids are having a potential role in the treatment of numerous
health complications of human beings. Antioxidant properties are one of the best pharmacological
properties of all classes of flavonoidal compounds. A significant amount of these flavonoidal compounds
are needed in our daily routine diet.

Methods:
Cirsiliol also called 5,3′,4′-trihydroxy-6,7-dimethoxyflavone is a flavonoidal class chemical
found to be present in different plants including Salvia guaranitica. Various literature databases
have been searched to know the biological potential of the cirsiliol in medicine. Different scientific
research data of cirsiliol have been collected from various literature sources and analyzed in the present
work. Detail pharmacological activities of cirsiliol in medicine have been evaluated in the present
work through literature data analysis of various scientific research works. However analytical
data has also been collected and analyzed in the present work through different literature sources.

Results:
From the collected data, it was found that cirsiliol is present in the plants such as
Artemisia campestris, Artemisia scoparia, Centaurea jacea, Centaurea phyllocephala, Crossostephium
chinense, Dracocephalum tanguticum, Eupatorium lindleyanum, Hyptis pectinata, and
Iris germanica. Pharmacological data analysis revealed the biological importance of cirsiliol
against cancer, inflammatory diseases, obesity-related insulin resistance, and respiratory disorders.
However, the biological potential on ileum, benzodiazepine receptor, arachidonate 5-lipoxygenase,
and xanthine oxidase has also been well summarized in the present investigation. High-performance
liquid chromatography, bioactivity-guided isolation techniques, UPLC-ESI-MS/MS, LCMS
and HPLC, and other forms of chromatographic techniques have been applicable for the analysis
of cirsiliol in the various plants material.

Conclusion:
The present investigation revealed the biological importance and therapeutic benefit
of cirsiliol in medicine for the development of better remedies against human disorders.
Application of the Templates TIDieR and CERT Reveal Incomplete Reporting and Poor Replicability of Exercise Interventions for Type 2 Diabetes Mellitus
Authors: Hacke Claudia , Schreiber Janika , Weisser Burkhard 
Published: August 2021

Background:Exercise is strongly recommended for the management of type 2 diabetes mellitus (T2DM). However, incomplete intervention reporting in clinical trials limits the replication of exercise protocols. As previously demonstrated by us for exercise and hypertension, the reporting quality might also be insufficient in studies with respect to T2DM and exercise.Objective:The aim of the study was to assess the completeness of exercise intervention reporting in randomized controlled trials (RCTs) for T2DM.Methods:Two independent reviewers applied the Consensus on Exercise Reporting Template (CERT) and the template for intervention description and replication (TIDieR) to 23 exercise trials obtained from the most recent and frequently cited meta-analysis in current guidelines. The completeness of reporting was evaluated, focusing on the F.I.T.T. components (frequency, intensity, time, type). Interrater agreement and associations with publication year and journal impact factor were examined.Results:Mean CERT score was 11/19 (range 5-17), and 8/12 (range 4-12) for TIDieR. F.I.T.T. components were almost completely described, whereas overall completeness of exercise reporting was 60% and 68% (CERT and TIDieR). Replication of each exercise of the respective program was not possible in 52% of interventions. The majority of items had shown excellent agreement. No associations with publication year or impact factor were found.Conclusion:Exercise interventions were not found to be sufficiently reported in RCTs that currently guide clinical practice in T2DM. Replication in further studies or clinical practice is limited due to poor exercise description. We suggest the use of more specific CERT for reporting results of exercise interventions. Further refinement for internal diseases is needed to better describe exercise interventions.
The Role of Biofactors in Diabetic Microvascular Complications
Authors: Ziegler Dan , Porta Massimo , Papanas Nikolaos , Mota Maria , Jermendy György , Beltramo Elena , Mazzeo Aurora , Caccioppo Andrea , Striglia Elio , Serhiyenko Victoria , Serhiyenko Alexandr , Rosta László , Stirban Ovidiu Alin , Putz Zsuzsanna , Istenes Ildikó , Horváth Viktor , Kempler Peter 
Published: August 2021

:
Microvascular complications are responsible for a major proportion of the burden associated
with diabetes contributing to substantial morbidity, mortality, and healthcare burden in people
with diabetes. Retinopathy, nephropathy, and neuropathy constitute the leading causes of blindness,
end-stage renal disease, and lower-extremity amputations, respectively. Since the efficacy of
causal therapies of diabetic microvascular complications is limited, especially in type 2 diabetes,
there is an unmet need for adjunct treatments which should be effective despite ongoing hyperglycemia.
Experimental studies have indicated that diabetic microvascular complications can be prevented
or ameliorated by various biofactors in animal models by interfering with the pathophysiology
of the underlying condition. Some of the findings related to biofactors, like α-lipoic acid and
benfotiamine, could be translated into the clinical arena and confirmed in clinical trials, especially
in those focusing on diabetic polyneuropathy. Given the micronutrient nature of these compounds,
their safety profile is excellent. Thus, they have the potential to favorably modify the natural history
of the underlying complication, but long-term clinical trials are required to confirm this notion.
Ultimately, biofactors should expand our therapeutic armamentarium against these common, debilitating,
and even life-threatening sequelae of diabetes.
Analisando sentimentos no Tripadvisor: a voz do consumidor como parâmetro decisório na medição da qualidade da informação em museus
Authors: Dutra Larissa Fernandes , Gosling Marlusa de Sevilha 
Published: August 2021

O objetivo deste artigo é identificar parâmetros que auxiliem gestores de museus na medição da qualidade da informação de suas instituições. Para isso, foram recuperadas 1900 avaliações em língua portuguesa, de setembro de 2017 a outubro de 2019 postadas na plataforma TripAdvisor, referentes ao Museu do Amanhã, localizado no Rio de Janeiro – RJ. A partir de uma análise de conteúdo foram excluídas as avaliações não relacionadas ao tema “informação museal”, restando 701 comentários. Através do sistema web iFeel, foram rodados 18 métodos diferentes de análise de sentimento e aplicados testes de assertividade em cada um deles. O método Umigon foi considerado o mais adequado na categorização de opiniões positivas, negativas e neutras para o banco de dados trabalhado. O maior número de sentimentos negativos a respeito da qualidade da informação no Museu do Amanhã relaciona-se a funcionários mal informados, a informação institucional desorganizada e a ausência de sinalização interna. Em se tratando de sentimentos positivos, percebeu-se que a relevância da informação transmitida pelas exposições e os altos níveis de interatividade para recuperação de informações do acervo foram os maiores favorecedores. Os resultados possibilitaram, ainda, a construção de parâmetros que poderão nortear tomadores de decisão de diversos outros museus quanto a temática qualidade da informação.
Testing the Limits of Jurisdiction in Investor-State Arbitration in Svalbard’s Waters: Peteris Pildegovics and SIA North Star v. Kingdom of Norway
Authors: Schatz Valentin 
Published: August 2021

On 1 April 2020, the Latvian fishing company SIA North Star and its owner Peteris Pildegovics initiated an investor-State arbitration against Norway (Peteris Pildegovics and SIA North Star v. Kingdom of Norway) at the International Centre for Settlement of Investment Disputes (ICSID). This case is not only Norway’s first ever ICSID case, but also the first publicly known investor-State arbitration in which an operator of a fishing vessel has brought a claim against a coastal State for allegedly unlawful exercise of prescriptive and enforcement jurisdiction in relation to fisheries. The case raises intricate questions concerning the limits of jurisdiction ratione materiae and jurisdiction ratione personae of investment tribunals.
Facile Hydrothermal Preparation of Flower-Like Tio2 Nanostructure With Enhanced Photocatalytic Activity
Authors: Kamol Dey 
Published: August 2021

This paper demonstrated the preparation of flower-like TiO2 nanostructures by low temperature hydrothermal process from TiO2 nanoparticles. The as-synthesized TiO2 nanoparticles and flower-like TiO2 nanostructures were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM) and N2 adsorption-desorption measurements. The flower-like TiO2 nanostructures possessed good crystallinity, showed fairly large surface area of 220 m2/g and exhibited better photocatalytic degradation of rhodamine B than TiO2 nanoparticles under simulated solar radiation.
Efektifkah Model Pembelajaran Kooperatif Tipe Numbered Head Together Terhadap Hasil Belajar Matematika
Authors: Citrawatiningsih Eny 
Published: August 2021

Penelitian ini bertujuan untuk mengetahui perbedaan hasil belajar matematika siswa dalam pembelajaran menggunakan model pembelajaran kooperatif tipe NHT dengan siswa yang menggunakan model pembelajaran langsung serta untuk mengetahui manakah yang lebih efektif model pembelajaran kooperatif tipe NHT atau model pembelajaran langsung.Populasi dalam penelitian ini adalah siswa kelas VIII SMP Muhammadiyah 3 Yogyakarta. Sampel yang digunakan sebanyak dua kelas yaitu kelas eksperimen dan kelas kontrol. Pengambilan sampel pada penelitian ini menggunakan teknik nonprobability sampling jenis purposive sampling. Pengumpulan data yang digunakan yaitu berupa pilihan ganda. Pengujian instrumen yang digunakan berupa uji validitas, uji daya beda, dan uji reliabilitas. Teknik analisis data yang digunakan untuk uji prasyarat analisis adalah uji normalitas dengan rumus Chi-Kuadrat, uji homogenitas dengan rumus uji bartlett dan uji hipotesis menggunakan uji-t dua pihak dan satu pihak.Berdasarkan hasil analisis pada taraf signifikan α=5% dan derajat kebebasan = 48 diperoleh maka diterima. Sehingga dapat disimpulkan bahwa tidak terdapat perbedaan hasil belajar matematika siswa dalam pembelajaran menggunakan model pembelajaran kooperatif tipe NHT dengan siswa yang menggunakan model pembelajaran langsung, serta model pembelajaran kooperatife tipe NHT tidak lebih efektif dari model pembelajaran langsung.
Peningkatan Aktivitas Dan Hasil Belajar Materi Bilangan Real Melalui Penerapan Model Pembelajaran Kooperatif Tipe Teams Games Tournament (TGT) Bagi Peserta Didik Kelas X APHP-3 Semester Gasal SMK Negeri 2 Slawi Tahun Pelajaran 2019/2020
Authors: Rusmiasih Rusmiasih 
Published: August 2021

Penelitian ini dilatarbelakangi oleh permasalahan yang ditemui dalam proses pembelajaran mata pelajaran matematika di SMK Negeri 2 Slawi kelas X APHP-3. Pada kondisi awal, proses pembelajaran matematika berjalan kurang optimal. Siswa tampak kurang antusias untuk terlibat dalam kegiatan pembelajaran dan tidak mengalami pembelajaran bermakna dan hal ini berujung pada rendahnya hasil belajar. Penelitian ini bertujuan untuk meningkatkan aktivitas dan hasil belajar materi bilangan real pada siswa kelas X APHP-3 SMK Negeri 2 Slawi semester gasal tahun pelajaran 2019/2020. Sebagai subjek penelitian adalah siswa kelas X APHP-3 sejumlah 30 orang. Metode penelitian yang digunakan adalah penelitian tindakan kelas yang terdiri dari 2 siklus. Setiap pelaksanaan satu siklus terdiri dari tahapan perencanaan, tindakan, pengamatan dan refleksi. Alat pengumpulan data berupa soal tes untuk mengukur hasil belajar siswa pada materi bilangan real dan lembar pengamatan yang berisi hasil pengamatan aktivitas siswa selama proses pembelajaran materi bilangan real berlangsung. Hasil penelitian menunjukkan bahwa penggunaan model pembelajaran kooperatif tipe Teams Games Tournament (TGT) dapat meningkatkan aktivitas dan hasil belajar materi bilangan real pada siswa kelas X APHP-3 SMK Negeri 2 Slawi semester genap tahun pelajaran 2019/2020. Prosentase aktivitas belajar meningkat dari 65,83% pada siklus I menjadi 80,83% pada siklus II dan prosentase ketuntasan hasil belajar klasikal meningkat dari 63,33% pada siklus I menjadi 90,00 % pada siklus II
Era uma vez...de Benjamin Lacombe
Authors: Debus Eliane 
Published: August 2021

Era uma vez..., de Benjamin Lacombe, é um livro que é arte pura, magistralmente sedutor pela sua arquitetura física e imagens insólitas. Um livro pop-up, com personagens dos contos clássicos para infância (Polegarzinha, Pinóquio, Madame Butterfly, Chapeuzinho Vermelho, Alice no País das Maravilhas, O Barba Azul, A Bela Adormecida e Peter Pan), que desfilam pelas páginas em dobraduras em três dimensões. Talvez Madama Butterfly se distancie das narrativas feéricas, mas por certo, Lacombe a introduziu com perfeição na sua insólita construção.
Disparidades por etnia en la mortalidad por minas antipersona: un análisis a nivel país
Authors: Rodríguez-Narváez José G. , Castillo Andrea , González Jessica , González Alejandro , Manzano-Núñez Ramiro , González Felipe , García Alberto F 
Published: August 2021

Introducción. El Registro Colombiano de Víctimas de Lesiones por Minas Antipersona fue lanzado por el gobierno de Colombia con el objetivo de recolectar información sobre los casos de heridos por minas antipersona en el país. El propósito de este estudio fue investigar las disparidades de mortalidad entre las víctimas de lesiones por minas antipersona, en función de la pertenencia a una minoría étnica.
Métodos. Se hizo una regresión logística multivariable para examinar la asociación entre minorías étnicas y mortalidad en las personas heridas por minas antipersona.
Resultados. Se registraron 10.306 casos de lesiones por minas antipersona, de los cuales 430 eran personas pertenecientes a grupos étnicos minoritarios (indígenas o afrodescendientes). De estos, 85 (19,7 %) eran mujeres, 156 (36,2 %) eran menores de 18 años y 427 (99,3%) vivían en áreas rurales. La mortalidad fue significativamente mayor (29,3 %) en comparación con la población mestiza (18,5 %; p < 0,001). Después de ajustar por sexo, edad, soldado en servicio activo, área rural y volumen de casos por departamento, encontramos que las minorías étnicas tenían mayores probabilidades de morir (OR = 2,03; IC95% 1,61- 2,56; p < 0,001).
Discusión. Encontramos una asociación entre la pertenencia a una minoría étnica y una mayor probabilidad de mortalidad con lesiones causadas por minas antipersona. Estos hallazgos deberían alentar a los legisladores de las zonas rurales de Colombia a trabajar más diligentemente, para reducir las consecuencias nocivas de las lesiones causadas por estos artefactos en los grupos étnicos minoritarios.
Islam and its role in the civilizational development of Côte d’Ivoire
Authors: Sadovskaya Lubov M. 
Published: August 2021

The article analyzes the evolution of Islam in Côte d’Ivoire in the light of the profound changes that have taken place in the country since independence in 1960 and up to the present day. The author explores the reasons for the rapid increase in the number of Islamized residents compared to other West African countries, especially during the first 30 years of independent development. This was a period of awakening of the collective consciousness and organizational cohesion of Ivorian Muslims. The second stage, since the first multiparty elections in the early 1990s, is associated with the politicization of religion, with a new form of Islamic religious culture, especially in cities - proselytism.
The tariqas, due to their lack of organization, play a secondary role in the modern history of the Muslim societies of Côte d’Ivoire. In addition, the modernization processes have further weakened their influence. Spiritual brotherhoods did not become a barrier to the spread of reformist teachings that were associated with Sunni Islam, a departure from Sufi spirituality. The reformist elite of the Ivorian Muslim community made extensive use of the Quranic concept of da&apos;wa in their religious propaganda, with its ideology borrowed from the Arab-Islamic world. Its main goal was the re-islamization of Muslim society, the introduction of political Islam.
The paper examines the problems of relations between Ivorian Muslims and Christians, which have not always been peaceful, especially during periods of military and political crises, when they were intertwined with ethnic ones. The coming to power in 2011 of A.Ouattara, the first Muslim president, contributed to the preservation of a stable balance between faiths thanks to his clerical policy.