bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of the relationship between government and pharmaceutical enterprises on social contribution during the public health emergency: an empirical study
Authors: Zhuang Qian , Wang Huan , Bai Qiqi , Liang Jingwen 
Published: February 2025

IntroductionDuring the COVID-19 pandemic, vaccines and specific drugs are seen as indispensable solutions to ending or responding to the pandemic, and pharmaceutical enterprises are in the spotlight. The Chinese government has made active efforts to guide pharmaceutical enterprises to make appropriate social contribution during the public health emergency. This study explores how government-enterprise relationship promotes this process.MethodsUsing the financial and textual data of China's listed pharmaceutical companies and policy data from the official website of the Chinese health-related government departments, this study drew the social contribution through text analysis, and established the response index of pharmaceutical companies to the government—the government-enterprise alignment index (GE_Ali) based on the formula of elasticity for reference. Then a series of regressions are used to do the empirical tests.ResultsThis study found the more responsive pharmaceutical companies were to government, the greater their contribution to society during the pandemic, mainly through increasing the intensity of drug R&amp;D, production and promotion, and the good communication mechanism between the two formed a mediating effect.DiscussionThe nature of state ownership, the presence of embedded party organizations, and the location in the provincial capital city had significant effects on the realization of a high level of government-enterprise alignment positively affecting the social contribution. This study confirms that the Chinese government has made enterprises a part of social governance, which is a global hotspot, through the embedding of party organizations. It also indicates that the government needs to re-recognize its key role in shaping social contribution, especially in distinguishing its responsibilities between normal and emergency situations.
Worldwide research trends of pregnancy hypertension in epigenetics field
Authors: Yuan Didi , Huang Yangqing , Liu Hanqi , Tang Haotian , Liu Junwen 
Published: February 2025

IntroductionHypertension in pregnancy (HIP) poses significant health risks for both mothers and infants. Development of HIP is influenced by genetic and environmental factors, with epigenetic modifications partially explaining underlying mechanisms. Bibliometric tools aid researchers in quickly gaining insights into field dynamics and trends.MethodsIn this investigation, we conducted a search for relevant publications in the Web of Science Core Collection database using specific keywords. We employed Citespace and WOSviewer software for analysis of interconnections and co-occurrence of information across publications, countries, authors, institutions, keywords and cited literature. Ultimately, we identified 4,316 research papers on hypertension in pregnancy within the epigenetics domain (HIPE).ResultsOur analysis revealed that China had the highest number of publications (n = 1,353, 31.35%), while the University of Melbourne was the most prolific institution (n = 107, 2.48%). Among author analysis, Tong S emerged as highly productive (n = 41, 0.95%). Preeclampsia (PE) emerged as being extensively studied among various types of HIP. High-frequency keywords associated with HIP mechanisms included oxidative stress, proliferation, apoptosis and invasion. Regarding epigenetics-related terms, DNA methylation, mRNA and ncRNA exhibited distinct heat burst periods. The number of HIPE papers demonstrated an upward trend observed through three stages of growth.DiscussionOur bibliometric-based study provides novel insights into current research progress on HIP from an epigenetic perspective, serving as a source of new ideas and inspiration for future investigations of HIP diseases.
Assessing vitamin D's impact on pregnancy success: a predictive model for assisted reproductive technology outcomes
Authors: Jiang Songwei , Chen Zushun , Li Liuming 
Published: February 2025

ObjectiveTo investigate the correlation between vitamin D levels and clinical pregnancy rates in infertile women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) procedures and to assess the utility of vitamin D levels in developing a predictive model for assisted reproductive technology (ART) outcomes.MethodsA total of 188 infertile patients receiving their initial IVF or ICSI treatment at our reproductive center between June 2020 and July 2021 were selected for data collection. Vitamin D levels and other relevant ART-related factors were used to construct a predictive model.ResultThe multivariate regression analysis revealed that several independent variables significantly impacted ART pregnancy outcomes, including infertility age, vitamin D level, reproductive anti-Müllerian hormone, antral follicle count, Gn dose, daily endometrial thickness after human chorionic gonadotropin (HCG) administration, and number of retrieved eggs. The area under the receiver operating characteristic curve for this comprehensive model was 75.34%, with a standard error of 0.045 and p-value of 0.003 (95% confidence interval 0.712–0965). Furthermore, the multivariate regression analysis identified specific independent variables that might influence vitamin D levels, such as the number of embryos obtained, daily endometrial thickness after HCG administration, and clinical pregnancy.ConclusionThe developed predictive model integrating serum 25-Hydroxyvitamin D level and ART-related factors holds significant clinical value in forecasting pregnancy outcomes.
Exploring the supply side dynamics of agritourism in Tamil Nadu
Authors: Sennimalai Sarath , Rao Badiya Venkata , Sivakumar S. D. 
Published: February 2025

IntroductionAgritourism is an emerging sector with the potential to drive rural development, economic diversification, and cultural heritage preservation. In Tamil Nadu, agritourism remains underexplored from a supply-side perspective. This study investigates the motivations, operational challenges, and expectations of farmers engaged in agritourism to understand its sustainable development potential.MethodsA mixed-methods approach, guided by grounded theory, was adopted to examine supply-side dynamics. Data were collected from 20 agritourism farm owners in the Coimbatore district of Tamil Nadu through structured questionnaires using a five-point Likert scale. Qualitative insights were also gathered through in-depth interviews to supplement quantitative findings.ResultsFindings reveal that farmers are primarily motivated by economic sustainability, additional income generation, rural heritage preservation, and farm diversification. However, key barriers include inadequate agritourism licensing, insufficient public awareness, and limited marketing efforts. Farmers also face challenges in accessing institutional support and navigating regulatory frameworks.DiscussionTo promote sustainable agritourism, the study recommends the establishment of a dedicated agritourism development committee, the formulation of specific government guidelines, and the integration of agritourism awareness into school curricula. These measures can enhance visibility, create employment opportunities, and ensure the long-term sustainability of agritourism in Tamil Nadu. This research provides valuable insights for policymakers and stakeholders, aiming to strengthen agritourism as a viable rural enterprise.
Cold water ingestion ameliorates increase in core temperature and discomfort during simulated motor racing in a hot environment: a randomized trial
Authors: Bird Stephen Richard , Troynikov Olga , Watson Chris , Cohen Marc , Sostaric Simon 
Published: February 2025

IntroductionFormula One and other motor car racing drivers race for prolonged periods in hot conditions wearing protective apparel that impairs heat loss. They are thus at risk of a significantly elevated core temperature. The aims of this study were to determine whether the voluntary ingestion of cold fluid aided thermoregulation more effectively than the voluntary ingestion of ambient temperature fluid in a simulated motor racing environment.MethodsEight male participants commenced two 120-min simulated motor racing trials in an environmental chamber (40°C, 50% humidity). During one trial they were provided with 1 L of ambient temperature water (AWT), whilst in the other trial the water temperature was ∼5°C (CWT). A drinking schedule of “1 sip every four minutes” was advocated. Participant core temperature, skin temperature and heart rate were recorded continuously, whilst thermal comfort, response time and cognitive function were assessed at 30-min intervals.ResultsAll participants successfully completed their CWT, but only two completed the full 120-mins of their AWT (AWT trial duration ranged from 80 to 120 min). Despite encouragement to drink more, both the rate of consumption (AWT 333 ± 103 v CWT 436 ± 99 ml/h) and total volume of water consumed (AWT 585 ± 233 v CWT 872 ± 198 ml) were less in the AWT (p &lt; 0.005). At the 75-min point of the trials, participant core temperatures had increased by 1.26 ± 0.29 in AWT and 0.81 ± 0.30 in CWT. Furthermore, at the point of trial cessation, core temperature in the AWT had increased by 1.69 ± 0.36°C, but only 1.17 ± 0.52°C in the CWT (p &lt; 0.05). Participants reported less discomfort and a lower rating of perceived exertion during the CWT. In both trials, response time to the cognitive test decreased as the trials progressed, with no evident difference in response time nor cognitive function between the two trials.DiscussionThe ingestion of cold water was associated with an ability to continue with volitional performance and associated with an ameliorated increase in core temperature as well as providing psychological benefits of cold “refreshment”.
Clinical efficacy of one-hole split endoscopy vs. unilateral biportal endoscopy for the treatment of single-segment lumbar spinal stenosis: a retrospective study with 2-year follow-up
Authors: Qing Peidong , Guo Wenlong , Xie Shiming , Zhao Shengxin , Cui Liqiang , Li Mingfan , Gong Shuangquan , Hu Youpeng 
Published: February 2025

BackgroundOne-hole split endoscopy (OSE) is a novel endoscopic technique proposed by Chinese scholars in recent years. Currently, data is lacking regarding the long-term efficacy of OSE for treating lumbar spinal stenosis (LSS). This study aimed to compare the long-term efficacy of OSE and unilateral biportal endoscopy (UBE) in LSS treatment.MethodsThe clinical data of 77 patients diagnosed with LSS at our hospital between January 2020 and March 2022 were retrospectively analyzed. Forty-one patients were treated with OSE, and 36 were treated with UBE. Perioperative indicators such as operation time, blood loss, fluoroscopy times, incision length, hospital stay, follow-up time, complications, and C-reactive protein level preoperatively and 3 days postoperatively were recorded. Visual analog score (VAS) and Oswestry disability index (ODI) were recorded preoperatively and at 1, 3, 6, 12, and 24 months postoperatively to evaluate pain and functional disability. The dural sac cross-sectional area (CSA), lumbar range of motion (ROM), and sagittal translation (ST) of the surgical segment were recorded preoperatively and 3 days postoperatively to evaluate lumbar stability. Clinical efficacy was assessed at the final follow-up using the modified Macnab criteria.ResultsVAS and ODI scores significantly improved at each postoperative follow-up in both groups compared with preoperative values (P &lt; 0.05), with no significant difference between the groups (P &gt; 0.05). However, OSE had a shorter operation time, less blood loss, and shorter incision length than UBE (P &lt; 0.05). Postoperative CSA was significantly increased compared to the preoperative CSA (P &lt; 0.05), with no significant difference between the groups (P &gt; 0.05). Postoperative ROM and ST increased; however, there was no significant difference compared to preoperative values (P &gt; 0.05). The complication rates in the OSE (n = 2, 4.88%) and UBE (n = 2, 8.33%) groups were not significantly different (x2 = 0.023; P = 0.880). Clinical efficacy was assessed at the last follow-up using the modified MacNab criteria. Thirty-eight (92.68%) and 34 (94.44%) patients in the OSE and UBE groups, respectively, demonstrated excellent or good efficacy, with no significant difference in the efficacy rate between the groups (x2 = 0.151, P = 0.985).ConclusionOSE and UBE showed satisfactory long-term efficacy and safety for LSS treatment. However, OSE has a shorter operation time, less blood loss, and shorter incision length, and can be an alternative to UBE.
The Hypothesis of the Interplay Between Air Particulate Matter PM2.5 and Acute Cellular Rejection Episodes Following Heart Transplantation
Authors: Urbanowicz Tomasz , Skotak Krzysztof , Konecka-Mrówka Dominika , Wachowiak-Baszyńska Hanna , Skowronek Rafał , Sikora Jędrzej , Bratkowski Jakub , Kaczmarek Jan , Misiorny Maksymilian , Straburzyńska-Migaj Ewa , Nożyński Jerzy , Jemielity Marek 
Published: February 2025

Background: In end-stage HF, interventional therapy is the treatment of choice, including mechanical circulatory support and heart organ transplantation. Acute cellular rejection is considered a major impediment to the long-term survival of cardiac allografts. The aim of this study is to point out a possible relationship underlying acute cellular rejection risk in heart organ recipients. Methods: A total of 30 (25 (83%) men and 5 (17%) women) heart organ recipients with a median (Q1–Q3) age of 49 (38–60) were enrolled in the analysis. The results from repeated hospitalizations due to protocolar endomyocardial biopsies performed between one and three months following the heart transplantation in relation air pollution exposure were taken into the analysis. Results: The median (Q1–Q3) observation time after organ transplantation was 92 (82–97) days. A significant difference in PM2.5 exposure between the rejection group (16.10 (14.24–17.61)) μg/m3 and the non-rejection group (11.97 (9.85–12.97)) μg/m3 was noticed (p < 0.001). The odds ratio (95% confidence interval) for acute rejection prediction related to PM2.5 was 1.79 (1.11–2.89), p = 0.018. The reviewer operator curve for acute cellular rejection related to PM2.5 exposure was performed, and the area under the curve (AUC) was 0.873, yielding a precision of 0.600 and an f-measure of 0.545. The predicted residual plots for PM2.5 indicated a 50% increased risk for PM2.5 above 16 μg/m3 and of 91% for PM2.5 above 20 μg/m3. Conclusions: The single-center study was performed on a limited number of heart organ recipients and was related to personalized individual calculations of PM2.5 exposure. The study represents a personalized approach and indicates possible links to the hypothesis, which should be verified on a higher volume of patients.
Effectiveness of application of apple biological protection systems against green and red-headed apple aphids of the Western Forest Steppe of Ukraine
Authors: Hunchak M. 
Published: February 2025

Goal. Research on the effectiveness of apple tree protection systems based on the use of biological preparations against green and red-headed apple aphids in the conditions of the Western Forest Steppe.
Methods. The distribution of pests was recorded depending on the phases of apple tree development in accordance with generally accepted methods. The technical efficiency of insecticides was determined after 2 and 7 days. Statistical processing of the results was carried out according to generally accepted methods.
Results. During the monitoring of the phytosanitary state, it was established that during 2022—2023, in the conditions of the Western Forest Steppe of Ukraine, significant damage was caused to the agrocenosis of apple trees by green and red-headed apple aphids. The research results established that the application of the bioprotection system of apple plantations No. 1 (Actophyt BT (aversectin C, 0.2%), k.e.; Biospectr BT (Pseudomonas bacteria, titer not lower than 5.0 × 109 CFU/cm3), p.; Bitoxybacillin BT (living cells of Bacillus thuringiensis var. thuringiensis, titer not lower than 2.0 × 109 CFU/ cm3 and spore-crystalline complex with toxins β-exotoxin and δ-endotoxin, r.) provided effectiveness against green apple aphid within 68.4—83.4%, and against red-headed apple aphid — 69.2—75.0%. When applying the following protection system (Bitoxybacillin BT, r. + Biospectr BT, r.; Actofit BT, k.e. + Bitoxybacillin BT, r.; Boverin BT (Beauveria fungi, viable cell titer not lower than 3.0 × 109 CFU/ cm3, p.) effectiveness against green apple aphid was 65.5—80.0%, and against red-headed apple aphid — 63.3—79.2%. Application of bioprotection system No. 3 (Biospectr BT, r. + Actofit BT, k.e.; Metarizin BT (Metarhizium fungi, titer of viable cells not lower than 2.0 × 109 CFU/ cm3), r. + Boverin BT, r.; Bitoxybacillin BT, r. + Biospectr BT, r.) made it possible to reduce the number of green apple aphids by 71.9—83.2% and red-headed apple aphids by 73.1—78.3%. During the study of apple tree protection systems, which were based on the introduction of biopreparts, against green and gray apple aphids in the Western Forest Steppe of Ukraine, the yield was 15.5—15.8 t/ha.
Conclusions. All apple bioprotection systems that were studied in the conditions of the Western Forest Steppe of Ukraine ensured high yield rates and a high level of protection of apple plantations against green and red-headed apple aphids. The technical efficiency of the bioprotection systems used against the green apple aphid was 65.5—83.4%, against the red-headed apple aphid — in the range of 63.3—79.2%. The yield of apple plantations during the study of apple tree protection systems, which were based on the use of drugs of biological origin, was 15.5—15.8 t/ha.
Integração de Tecnologias digitais e L-PRF na implantodontia
Authors: Da Silva Alexandre , Prates Santos Matheus , Luis Velásquez Molina Ives , Elemer Finger Elton , Mazzaglia Giuseppe , Cristina Dallarmi Reis Ana , Da Silva Brabo Rosanne , Macahiba Domingues Monique , Lobato Barreto Lucas , Aurélio Ferreira Luiz Marco , Vasconcelos de Souza Arruda Fabyana , Carolina Medeiros de Lima da Silva Ana , Reis Moreira Myrella 
Published: February 2025

A evolução das tecnologias digitais na implantodontia tem aprimorado a precisão diagnóstica, o planejamento cirúrgico e a reabilitação protética. A associação dessas inovações com biomateriais, como a fibrina leucoplaquetária rica em plaquetas (L-PRF), tem demonstrado benefícios na osteointegração e na regeneração tecidual. Objetivo: Este estudo visa avaliar os impactos da integração entre tecnologias digitais e L-PRF na implantodontia. Metodologia: Foi realizada uma revisão de literatura em bases de dados científicas, incluindo estudos clínicos e experimentais publicados nos últimos dez anos. Os critérios de inclusão envolveram pesquisas que abordam o uso de escaneamento digital, CAD/CAM, cirurgia guiada e L-PRF na implantodontia. Resultados: A literatura sugere que a utilização de tecnologias digitais melhora a precisão da instalação dos implantes e aperfeiçoa o tempo de reabilitação. O L-PRF, por sua vez, promove aceleração da cicatrização óssea e gengival, favorecendo a estabilidade dos implantes e a qualidade dos tecidos peri-implantares. A sinergia entre essas abordagens proporciona uma reabilitação mais previsível e minimamente invasiva. Conclusão: A combinação das tecnologias digitais com o L-PRF na implantodontia representa um avanço significativo, melhorando a eficiência dos procedimentos e favorecendo a regeneração tecidual. Estudos clínicos de longo prazo ainda são necessários para consolidar as evidências e ampliar a aplicabilidade clínica dessa abordagem.
IMPLEMENTASI PEMBELAJARAN SOSIODRAMA PADA MATA KULIAH PANCASILA DALAM MENINGKATKAN CIVIC SKILLS MAHASISWA
Authors: Wendy Anugrah Octavian  , Puspa Dianti  
Published: February 2025

ABSTRAK
Civic skills atau keterampilan sosial merupakan salah satu jenis keterampilan yang harus dimiliki oleh generasi muda dalam menghadapi berbagai permasalahan sosial terutama berbagai permasalahan yang tidak sesuai dengan nilai-nilai Pancasila. Mahasiswa sebagai generasi muda diharapkan mampu memahami bahwa Pancasila merupakan solusi dari berbagai permasalahan sosial yang ada di masyarakat, bangsa, dan negara. Melalui civic skills yang dimiliki para mahasiswa dapat ikut berpartisipasi dalam pemecahan berbagai permasalahan sosial tersebut. Salah satu peningkatan civic skills mahasiswa dapat dilakukan melalui proses pembelajaran di kelas dengan metode yang mampu memfasilitasi terbentuknya civic skills tersebut. Salah satu metode yang disarankan adalah sosiodrama. Jenis penelitian ini adalah deskriptif kualitatif dengan teknik pengumpulan data melalui observasi dan dokumentasi. Hasil penelitian menunjukkan bahwa melalui metode pembelajaran sosiodrama mampu meningkatkan civic skills mahasiswa baik pada indikator keterampilan intelektual maupun partisipasinya.

ABSTRACT
Civic skills or social skills are one type of skill that the younger generation must have in dealing with various social problems, especially various problems that are not in accordance with the values of Pancasila. Students as the younger generation are expected to be able to understand that Pancasila is a solution to various social problems that exist in society, nation and state. Through civic skills, students can participate in solving various social problems. One way to improve students' citizenship skills can be done through the learning process in the classroom with methods that are able to facilitate the formation of these citizenship skills. One method suggested is sociodrama. This type of research is descriptive qualitative with data collection techniques through observation and documentation. The results of the research show that the sociodrama learning method is able to improve students' civic skills both in terms of intellectual skills and participation.