bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anomalous dimensions from gauge couplings in SMEFT with right-handed neutrinos
Authors: Datta Alakabha , Kumar Jacky , Liu Hongkai , Marfatia Danny 
Published: February 2021

Abstract
Standard Model Neutrino Effective Field Theory (SMNEFT) is an effective theory with Standard Model (SM) gauge-invariant operators constructed only from SM and right-handed neutrino fields. For the full set of dimension-six SMNEFT operators, we present the gauge coupling terms of the one-loop anomalous dimension matrix for renormalization group evolution (RGE) of the Wilson coefficients between a new physics scale and the electroweak scale. We find that the SMNEFT operators can be divided into five subsets which are closed under RGE. Our results apply for both Dirac and Majorana neutrinos. We also discuss the operator mixing pattern numerically and comment on some interesting phenomenological implications.
Aktueller Stand der Impfung gegen SARS-CoV-2
Authors: Iking-Konert Christof , Specker Christof , Krüger Klaus , Schulze-Koops Hendrik , Aries Peer 
Published: February 2021

ZusammenfassungAm 21.12.2020 hat die EMA mit der mRNA-Vakzine BNT162b2 der Firmen BioNTech/Pfizer (Comirnaty®, BioNTech, Mainz, Deutschland; Pfizer, New York City, NY, USA) den ersten Impfstoff gegen SARS-CoV‑2 in der Europäischen Union zugelassen, am 06.01.2021 folgte bereits der zweite (Moderna®, Moderna, Cambridge, MA, USA). Viele weitere Zulassungen werden in Kürze folgen. Mit der Verfügbarkeit der Impfung sind bei Patienten/-innen genau wie bei Ärzten/-innen viele Fragen aufgekommen, die in diesem Hot-Topic-Artikel so aktuell wie möglich adressiert werden sollen.
Family history of prostate cancer and prostate tumor aggressiveness in black and non-black men;results from an equal access biopsy study
Authors: Jenkins Kimberly R. , Oyekunle Taofik , Howard Lauren E. , Wiggins Emily K. , Freedland Stephen J. , Allott Emma H. 
Published: February 2021

Abstract
Purpose
To test for racial differences in associations between family history (FH) of prostate cancer (PC) and prostate cancer aggressiveness in a racially diverse equal access population undergoing prostate biopsy.

Subjects/patients and methods
We prospectively enrolled men undergoing prostate biopsy at the Durham Veterans Administration from 2007 to 2018 and assigned case or control status based on biopsy results. Race and FH of PC were self-reported on questionnaires. Logistic regression was used to test the association between FH and PC diagnosis overall and by tumor aggressiveness [high- (Grade Group 3–5) or low-grade (Grade Group 1–2) vs. no cancer], overall, and stratified by race. Models were adjusted for age and year of consent, race, PSA level, digital rectal exam findings, prostate volume, and previous (negative) biopsy receipt.

Results
Of 1,225 men, 323 had a FH of PC and 652 men were diagnosed with PC on biopsy. On multivariable analysis, FH was associated with increased odds of high-grade PC in black (OR 1.85, p = 0.041) and all men (OR 1.56, p = 0.057) and was unrelated to overall or low-grade PC diagnosis, overall, or stratified by race (all p ≥ 0.325). In sensitivity analyses among men without a previous biopsy, results were slightly more pronounced.

Conclusion
In this setting of equal access to care, positive FH of PC was associated with increased tumor aggressiveness in black men, but not non-black men undergoing prostate biopsy. Further research is required to tease apart the contribution of genetics from increased PC awareness potentially influencing screening and biopsy rates in men with FH.
Working the Self: Truth-Telling in the Practice of Alcoholics Anonymous
Authors: Palm Fredrik 
Published: February 2021

AbstractThis article interrogates twelve step practice within Alcoholics Anonymous (AA) from the perspective of Foucault’s later work on governance, truth-telling and subjectivity. Recent critical studies of addiction tend to view self-help cultures like that of AA and related twelve step programs as integral parts of contemporary power/knowledge complexes, and thus as agents of the modern “will to knowledge” that Foucault often engages with. In line with the widespread Foucauldian critique of governmentality, addiction self-help culture is thus conceived as one that primarily reproduces abstract, neoliberal norms on health and subjectivity. The argument put forward in this article aims to upset this framework attending to a number of features of twelve step practice that, arguably, bear striking resemblances to Foucault’s later discussions of ethics, care of self and truth-telling. In this, it is suggested that a close study of AA practices, might interrupt assumptions about contemporary addiction discourse and its relationship to issues of truth and power often reproduced in Foucauldian critiques.
Celestina’s Influence on La casa de Bernarda Alba
Authors: López González Luis F. 
Published: February 2021

AbstractThis study argues that the breadth and depth of influence of Fernando de Rojas’s Celestina on Federico García Lorca’s La casa de Bernarda Alba is much greater than previously acknowledged. García Lorca borrowed from Rojas not only motifs, images, and characterization, but also symbols, structure, and the effusive rhetoric that characterizes Celestina and Melibea’s mode of expression. Lorca’s La casa contains a microcosm of the social institutions and cultural dynamics that predominate in Celestina’s world and, by extension, in Rojas’s society. In this comparative analysis, I hope to show the far-reaching influence that Celestina has had since its publication in 1499 up to the twentieth century. By reading Lorca’s play from this perspective, I also uncover new levels of meaning that help us interpret La casa based on the systems of intertextual relations that underprop La casa’s foundations.
Spatial variability of nitrogen dioxide and formaldehyde and residential exposure of children in the industrial area of Viadana, Northern Italy
Authors: Marcon Alessandro , Panunzi Silvia , Stafoggia Massimo , Badaloni Chiara , de Hoogh Kees , Guarda Linda , Locatelli Francesca , Silocchi Caterina , Ricci Paolo , Marchetti Pierpaolo 
Published: February 2021

AbstractChipboard production is a source of ambient air pollution. We assessed the spatial variability of outdoor pollutants and residential exposure of children living in proximity to the largest chipboard industry in Italy and evaluated the reliability of exposure estimates obtained from a number of available models. We obtained passive sampling data on NO2 and formaldehyde collected by the Environmental Protection Agency of Lombardy region at 25 sites in the municipality of Viadana during 10 weeks (2017–2018) and compared NO2 measurements with average weekly concentrations from continuous monitors. We compared interpolated NO2 and formaldehyde surfaces with previous maps for 2010. We assessed the relationship between residential proximity to the industry and pollutant exposures assigned using these maps, as well as other available countrywide/continental models based on routine data on NO2, PM10, and PM2.5. The correlation between NO2 concentrations from continuous and passive sampling was high (Pearson’s r = 0.89), although passive sampling underestimated NO2 especially during winter. For both 2010 and 2017–2018, we observed higher NO2 and formaldehyde concentrations in the south of Viadana, with hot-spots in proximity to the industry. PM10 and PM2.5 exposures were higher for children at < 1 km compared to the children living at > 3.5 km to the industry, whereas NO2 exposure was higher at 1–1.7 km to the industry. Road and population densities were also higher close to the industry. Findings from a variety of exposure models suggest that children living in proximity to the chipboard industry in Viadana are more exposed to air pollution and that exposure gradients are relatively stable over time.
Recent advances and future avenues in understanding the role of adipose tissue cross talk in mediating skeletal muscle mass and function with ageing
Authors: Wilhelmsen Andrew , Tsintzas Kostas , Jones Simon W. 
Published: February 2021

AbstractSarcopenia, broadly defined as the age-related decline in skeletal muscle mass, quality, and function, is associated with chronic low-grade inflammation and an increased likelihood of adverse health outcomes. The regulation of skeletal muscle mass with ageing is complex and necessitates a delicate balance between muscle protein synthesis and degradation. The secretion and transfer of cytokines, long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), both discretely and within extracellular vesicles, have emerged as important communication channels between tissues. Some of these factors have been implicated in regulating skeletal muscle mass, function, and pathologies and may be perturbed by excessive adiposity. Indeed, adipose tissue participates in a broad spectrum of inter-organ communication and obesity promotes the accumulation of macrophages, cellular senescence, and the production and secretion of pro-inflammatory factors. Pertinently, age-related sarcopenia has been reported to be more prevalent in obesity; however, such effects are confounded by comorbidities and physical activity level. In this review, we provide evidence that adiposity may exacerbate age-related sarcopenia and outline some emerging concepts of adipose-skeletal muscle communication including the secretion and processing of novel myokines and adipokines and the role of extracellular vesicles in mediating inter-tissue cross talk via lncRNAs and miRNAs in the context of sarcopenia, ageing, and obesity. Further research using advances in proteomics, transcriptomics, and techniques to investigate extracellular vesicles, with an emphasis on translational, longitudinal human studies, is required to better understand the physiological significance of these factors, the impact of obesity upon them, and their potential as therapeutic targets in combating muscle wasting.
Hybrides Projektmanagement
Authors: Albrecht Arnd , Albrecht Evelyn 
Published: February 2021

ZusammenfassungExzellentes Projektmanagement ist der kritische Erfolgsfaktor für alle Produktentwicklungen und Serviceleistungen in der Wirtschaft. Effektivität und Effizienz sind die Kernparameter, um die Zielerreichung erfolgreich zu gestalten. Globale Wertschöpfungsketten und Beteiligung vieler Stakeholder sowie regulatorische Implikationen führen zu einer immer komplexeren Projektsteuerung und -ausführung in der klassischen sequenziellen Abwicklung. Schwerer kalkulierbare Zeitaufwände und Kosten sowie die volatile Erwartungshaltung des Kunden lassen Projekte risikoreicher werden. Im Zuge der Arbeitswelt 4.0, wo nicht nur Automatisierungen und Künstliche Intelligenz (KI) eine Rolle spielen, haben sich neue agile Projektformen wie Scrum-Management etabliert. Es hat sich allerdings gezeigt, dass reine agile Formen sowohl organisationsbedingt als auch im Zusammenspiel vieler heterogener Partner nicht immer erfolgreich sind. Daraus haben sich Mischformen, sogenannter hybride Gebilde entwickelt, die im Projektmanagement als state of the art gesehen werden. Voraussetzung zur erfolgreichen Umsetzung ist eine hohe Professionalität aller Beteiligten und die Kenntnisse von klassischen und agilen Projektmanagement Formen. Neue Anforderungsprofile für Beteiligte im hybriden Projektmanagement werden diskutiert.
Risk stratification and subclinical phenotyping of dilated and/or arrhythmogenic cardiomyopathy mutation-positive relatives: CVON eDETECT consortium
Authors: Roudijk R. W. , Taha K. , Bourfiss M. , Loh P. , van den Heuvel L. , Boonstra M. J. , van Lint F. , van der Voorn S. M. , te Riele A. S. J. M. , Bosman L. P. , Christiaans I. , van Veen T. A. B. , Remme C. A. , van den Berg M. P. , van Tintelen J. P. , Asselbergs F. W. 
Published: February 2021

AbstractIn relatives of index patients with dilated cardiomyopathy and arrhythmogenic cardiomyopathy, early detection of disease onset is essential to prevent sudden cardiac death and facilitate early treatment of heart failure. However, the optimal screening interval and combination of diagnostic techniques are unknown. The clinical course of disease in index patients and their relatives is variable due to incomplete and age-dependent penetrance. Several biomarkers, electrocardiographic and imaging (echocardiographic deformation imaging and cardiac magnetic resonance imaging) techniques are promising non-invasive methods for detection of subclinical cardiomyopathy. However, these techniques need optimisation and integration into clinical practice. Furthermore, determining the optimal interval and intensity of cascade screening may require a personalised approach. To address this, the CVON-eDETECT (early detection of disease in cardiomyopathy mutation carriers) consortium aims to integrate electronic health record data from long-term follow-up, diagnostic data sets, tissue and plasma samples in a multidisciplinary biobank environment to provide personalised risk stratification for heart failure and sudden cardiac death. Adequate risk stratification may lead to personalised screening, treatment and optimal timing of implantable cardioverter defibrillator implantation. In this article, we describe non-invasive diagnostic techniques used for detection of subclinical disease in relatives of index patients with dilated cardiomyopathy and arrhythmogenic cardiomyopathy.
Traditions of Argumentation in Teachers’ Responses to Multilingualism in Early Childhood Education
Authors: Kultti Anne , Pramling Niklas 
Published: February 2021

AbstractIn this study, we investigate how professionals in early childhood education (ECE) reason about multilingualism. Empirical data are analyzed in terms of ‘traditions of argumentation’ which proposes that we cannot argue for something without, explicitly or implicitly, arguing against something else. The analyses use transcribed data from two focus groups conducted with teachers in two preschools in Sweden. These teachers had experience teaching culturally and linguistically diverse groups of children. The reoccurring rhetorical strategy used by the teachers to talk about their work with multilingual children used a set of contrasts. Three contrasts were identified: (1) I/we versus them (others); (2) here-and-now versus there-and-then; and (3) building ECE on research versus personal experience. The study has implications for teachers and students in preschool teacher education to understand the possible tensions and contrasts inherent in teaching culturally and linguistically diverse children. Rather than simplifying professional practice to either side of a dichotomy, teachers should be encouraged to understand and verbalize the bases of their professional knowledge, and understand the different positions from which they draw knowledge to inform practice.
The Arctic Carbon Cycle and Its Response to Changing Climate
Authors: Bruhwiler Lori , Parmentier Frans-Jan W. , Crill Patrick , Leonard Mark , Palmer Paul I. 
Published: February 2021

Abstract
Purpose of Review
The Arctic has experienced the most rapid change in climate of anywhere on Earth, and these changes are certain to drive changes in the carbon budget of the Arctic as vegetation changes, soils warm, fires become more frequent, and wetlands evolve as permafrost thaws. In this study, we review the extensive evidence for Arctic climate change and effects on the carbon cycle. In addition, we re-evaluate some of the observational evidence for changing Arctic carbon budgets.

Recent Findings
Observations suggest a more active CO2 cycle in high northern latitude ecosystems. Evidence points to increased uptake by boreal forests and Arctic ecosystems, as well as increasing respiration, especially in autumn. However, there is currently no strong evidence of increased CH4 emissions.

Summary
Long-term observations using both bottom-up (e.g., flux) and top-down (atmospheric abundance) approaches are essential for understanding changing carbon cycle budgets. Consideration of atmospheric transport is critical for interpretation of top-down observations of atmospheric carbon.
Micromouse 3D simulator with dynamics capability: a Unity environment approach
Authors: Zawadniak Pedro V. F. , Piardi Luis , Brito Thadeu , Lima José , Costa Pedro , Monteiro André L. R. , Costa Paulo , Pereira Ana I. 
Published: February 2021

AbstractThe micromouse competition has been gaining prominence in the robotic atmosphere, due to the challenging and multidisciplinary characteristics provided by the teams’ duels, being a gateway for those who intend to deepen their studies in autonomous robotics. In this context, this paper presents a realistic micromouse simulator developed with Unity software, a widely game engine with dynamics and 3D development platform used. The developed simulator has hardware-in-the-loop capabilities, aims to be simple to use, it can be customizable, and designed to be as similar as possible to the real robot configurations. In this way, the proposed simulator requires few modifications to port the microcontroller code to a real robot. Therefore, the framework presented in this work allows the user to simulate the development of new algorithm strategies dedicated to competition and also hardware updates. The simulation supports several mazes, from previous competitions and has the possibility to add different mazes elaborated by the user. Thus, the features and functionality of the simulator can serve to accelerate the project’s development of the beginning and advanced competitors, using real models to reduce the gap between the mouse robot behavior in the simulation and the reality. The developed simulation environment is available to the community.
Assessing the influence of neglected GC-FID variables on the multiple responses using multivariate optimization for the determination of ethanol and acetonitrile in radiopharmaceuticals
Authors: Hassan Hishar , Othman Muhammad Faiz , Zakaria Zainul Amiruddin , Ahmad Saad Fathinul Fikri , Abdul Razak Hairil Rashmizal 
Published: February 2021

AbstractAnalytical gas chromatography in line with a flame ionization detector (GC-FID) method was developed and validated for direct determination of organic solvents in [18F]fluoro-ethyl-tyrosine ([18F]FET), [18F]fluoromisonidazole ([18F]FMISO) and [18F]fluorothymidine ([18F]FLT). Variables of the splitless time (min) and injection temperature (°C) on the response of analysis time and resolution were optimized with the assistance of a two-level full factorial design and desirability function of Derringer. The proposed procedure was validated following the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) Q2 (R1) guideline. Excellent linearity, R2 > 0.990, indicated that approximately 99% of the response variance could be predicted from ethanol and acetonitrile concentrations ranging from 0.5 to 6.0 mg mL−1 and 0.1 to 0.8 mg mL−1, respectively. The proposed procedure has proved to be selective, sensitive, and accurate (90–110%), with excellent repeatability and precision (RSD < 2%). In the robustness analysis, the findings from the calculated Standardized Effects Values (SE) were insignificant (p > 0.05) and demonstrated that the proposed method was robust for a splitless time of 1.0 ± 0.5 min and an injection temperature of 210 ± 10 °C. The proposed method was also successfully used for the quantitative determination of ethanol and acetonitrile in [18F]FET, [18F]FMISO, and [18F]FLT. Both solvents were well separated (R, 4.1–4.3) within 4.5 min. Therefore, the proposed method is relevant for routine quality control analysis of all 18F-radiopharmaceutical derivatives for the direct determination of ethanol and acetonitrile.
Online Failure Diagnosis in Interdependent Networks
Authors: Shiri Davood , Akbari Vahid 
Published: February 2021

AbstractIn interdependent networks, nodes are connected to each other with respect to their failure dependency relations. As a result of this dependency, a failure in one of the nodes of one of the networks within a system of several interdependent networks can cause the failure of the entire system. Diagnosing the initial source of the failure in a collapsed system of interdependent networks is an important problem to be addressed. We study an online failure diagnosis problem defined on a collapsed system of interdependent networks where the source of the failure is at an unknown node (v). In this problem, each node of the system has a positive inspection cost and the source of the failure is diagnosed when v is inspected. The objective is to provide an online algorithm which considers dependency relations between nodes and diagnoses v with minimum total inspection cost. We address this problem from worst-case competitive analysis perspective for the first time. In this approach, solutions which are provided under incomplete information are compared with the best solution that is provided in presence of complete information using the competitive ratio (CR) notion. We give a lower bound of the CR for deterministic online algorithms and prove its tightness by providing an optimal deterministic online algorithm. Furthermore, we provide a lower bound on the expected CR of randomized online algorithms and prove its tightness by presenting an optimal randomized online algorithm. We prove that randomized algorithms are able to obtain better CR compared to deterministic algorithms in the expected sense for this online problem.
On Ruelle’s property
Authors: HUO SHENGJIN , ZINSMEISTER MICHEL 
Published: February 2021

AbstractIn this paper we investigate the range of validity of Ruelle’s property. First, we show that every finitely generated Fuchsian group has Ruelle’s property. We also prove the existence of an infinitely generated Fuchsian group satisfying Ruelle’s property. Concerning the negative results, we first generalize Astala and Zinsmeister’s results [Mostow rigidity and Fuchsian groups. C. R. Math. Acad. Sci. Paris311 (1990), 301–306; Teichmüller spaces and BMOA. Math. Ann.289 (1991), 613–625] by proving that all convergence-type Fuchsian groups of the first kind fail to have Ruelle’s property. Finally, we give some results about second-kind Fuchsian groups. [-3.2pc]
Intimately Old: From an Embodied to Emplaced Feminist Approach to Aging
Authors: Finlay Jessica 
Published: February 2021

AbstractAging transcends and intersects all structured social differences as a fluid complex of positionalities: a temporal situatedness in relation to gender, class, race, and sexuality. Age's operation as an organizing principle of power remains undertheorized in feminist philosophy. This article employs a geographical lens to spatialize feminist thought on old age to enrich understanding of factors underpinning expectations and practices of what particular bodies can and should do in particular spaces. Vignettes from twelve months of ethnographic fieldwork with six older individuals in a midwestern American city demonstrate the utility of advancing not just an embodied feminist philosophy of aging, but one that is emplaced to deepen understanding of the body as situated in time and space. A person's situatedness in dynamic place-events, ranging from daily life at home and engagement in supportive social spaces to experiences of discrimination and even inclement weather, produce distinct ways of being old. Investigating intimate geographies of later life from the micro to macro scale can help destabilize and challenge the objectification, control, and Othering of old people, the majority of whom are female. This article contributes greater “body a-where-ness” to feminist philosophy and stimulates novel investigation into the spatiotemporal situatedness of later life.