bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harnessing machine learning and AI-driven analytics to identify novel drug targets and predict chemotherapy efficacy in NSCLC
Authors: Qin Shaojia , Deng Biyu , Mo Dan , Zhang Zhengyou , Wei Xuan , Ling Zhougui 
Published: February 2025

IntroductionNon-small cell lung cancer (NSCLC) constitutes the majority of lung cancer cases and exhibits marked heterogeneity in both clinical presentation and molecular profiles, leading to variable responses to chemotherapy. Emerging evidence suggests that mitochondria-derived RNAs (mtRNAs) may serve as novel biomarkers, although their role in predicting chemotherapy outcomes remains to be fully explored.MethodsIn this study, peripheral blood mononuclear cells were obtained from NSCLC patients for analysis of the mtRNA ratio (mt_tRNA-Tyr-GTA_5_end to mt_tRNA-Phe-GAA), while thoracic CT images were processed to derive an AI-driven BiomedGPT variable. Although individual clinical factors (Sex, Age, History_of_smoking, Pathological_type, Stage) offered limited predictive power when used in isolation, their integration into a random forest model improved sensitivity in the training set, albeit with reduced generalizability in the validation cohort. The subsequent integration of the BiomedGPT score and mtRNA ratio significantly enhanced predictive performance across both training and validation datasets.ResultsAn all-inclusive model combining clinical data, AI-derived variables, and mtRNA biomarkers produced a risk score capable of discriminating patients into high- and low-risk groups for progression-free survival and overall survival, with statistically significant differences observed between these groups.DiscussionThese findings highlight the potential of integrating mtRNA biomarkers with advanced AI methods to refine therapeutic decision-making in NSCLC, underscoring the importance of combining diverse data sources in precision oncology.
Are individual differences in personality associated with COVID-19 infection? Examining the role of normative, maladaptive, and dark personality traits using structural equation modeling
Authors: Pourdehghan Parandis , Pincus Aaron L. , Mohammadi Mohammad Reza 
Published: February 2025

ObjectiveDuring the COVID-19 pandemic, people’s behaviors have been considered an important factor in the spread of coronavirus. This situation led us to examine the role of personality in human behavior and its outcomes during the pandemic. This study examined the effect of normative, maladaptive, and dark personality traits on the probability of COVID-19 infection as mediated by psychological and behavioral responses to the pandemic.MethodsThe data was collected from 740 Iranians (mean age = 33.34) completing Big Five-10, Personality Inventory for DSM-5-Brief Form (PID-5-BF)-Adult, Short Dark Triad (SD3), Depression, Anxiety and Stress Scale - 21 Items (DASS-21), and Protective Behaviors inventories. We used structural equation modeling to fit a model from the personality traits to COVID-19 infection through mediating effects of psychological and behavioral responses using cross-sectional data.ResultsAll path models examined fit the data well. The normative traits openness, conscientiousness, neuroticism, introversion, and disagreeableness were positively related to social distancing. The pathological traits antagonism, detachment, negative affectivity, disinhibition, and psychoticism, and dark traits psychopathy, narcissism, and Machiavellianism were negatively associated with social distancing. Finally, social distancing was negatively related to infection rates and fully mediated all personality links with infection (β = −0.17, p &lt; 0.001).ConclusionThe findings demonstrate that individual differences in personality predict behaviors crucial to pandemic mitigation. Social distancing can be, directly or indirectly, a significant underlying mechanism linking personality traits to the COVID-19 infection. Public health policymakers should consider personality-tailored interventions for maximizing preventive health behaviors and slowing the spread of infection. This knowledge also could contribute to more effective measures to prepare for public health emergencies in the future.
Social connections combat loneliness and promote wellbeing among college students coming out of the COVID-19 pandemic
Authors: Cipolletta Sabrina , Ronconi Lucia , Tomaino Silvia Caterina Maria 
Published: February 2025

IntroductionThe COVID-19 pandemic impacted young people's mental health but we still need to explore this impact in the long term. The aim of this study is to analyze college students' wellbeing and loneliness in relation to the impact of the COVID-19 pandemic, social support, and the frequency of activities carried out with others following the period of strictest restrictions.MethodsA total of 291 college students enrolled in an Italian University filled in an online questionnaire including measures of anxiety, depression, life satisfaction, loneliness, perceived social support, and the impact of COVID-19 on their quality of life.ResultsThe results showed that the greatest impact of the pandemic related to higher levels of loneliness, anxiety, depression and lower satisfaction with life. Conversely, greater social support and frequency of activities carried out with others were associated with lower levels of loneliness and depression, and higher satisfaction with life. Some differences related to gender and being a long-term international student.DiscussionThese results are important to inform interventions to support college students' wellbeing and foster social connections among them.
Racism in medical education and the entanglement of contents and (con-)texts: a participative reflection on teaching materials and the everyday experiences of racialized students and physicians in Germany
Authors: Vogt Hans , Piberger Patricia , Lazaridou Felicia Boma 
Published: February 2025

BackgroundInstitutional racism and racial disparities in healthcare have received greater focus in the public health sciences in recent decades. The role of medical education in this context has been researched in several studies, mostly in the US, but racism in medical education remains largely underresearched in Germany. The aim of this study is to show how racist knowledge and practices exist within German medical care and are systematically transmitted in German medical education, and how this may institutionally reproduce, legitimize, reinforce, and perpetuate disadvantages.MethodsBased on consultations and preliminary interviews with civic stakeholders and experts, teaching and learning materials in German medical education were randomly sampled. These materials served as a starting point for participative reflection on racist knowledge and practices in German medical education. In the first step, the contents of teaching and learning materials were analyzed to identify terms, themes, or concepts that propagate racist ideas. Thereafter, we sought expert feedback on the analyzed content through one-on-one interviews and focus groups with physicians and medical students who self-identify as affected by racism.ResultsOur study reveals two main findings. First, racist knowledge and practices are systematically transmitted and reproduced at different levels of German medical education. Second, the entanglement of multiple institutional dimensions contributes significantly to the perpetuation and legitimization of racist knowledge and practices in German medical education.ConclusionIn keeping with the state of research, the study was primarily exploratory in character and may serve as a starting point for future research on institutional racism in German healthcare and medical education. In addition to the findings that can be used to develop further research questions, initial recommendations for action by civil society, institutions, and policymakers may be derived from the interviews and focus group discussions.
The relationship between burnout, sense of coherence and job safety attitudes among nurses after coronavirus disease 2019 in China: a cross-sectional survey
Authors: Xue Fang , Liu Jing , Zhou Tong , Li Xiuchuan , Liu Chunfang , Li Xueer , Li Shuoshuo , Ye Ping , Zhang Jing 
Published: February 2025

ObjectiveTo investigate burnout, sense of coherence (SOC), and job safety attitudes among nurses in China after the coronavirus disease 2019 (COVID-19) pandemic.MethodsThis cross-sectional study included 302 front-line nurses from Fangcang shelter hospitals (FSHs) in China. Descriptive, univariate, Pearson’s correlation, and multiple linear regression analyses were conducted to analyze factors related to job safety attitudes of nurses toward FSHs.ResultsThe incidence of burnout among nurses in FSHs was 65.2%; 57.9% had a low level of SOC, the score for safety attitude was 74.47 (standard deviation = 13.33), and the agreement rate was 51%. Burnout was negatively correlated with SOC (r = −0.399, p &lt; 0.01) and safety attitudes (r = −0.141, p &lt; 0.05), and SOC was positively correlated with safety attitudes (r = 0.428, p &lt; 0.01). Personal accomplishment, depersonalization, changes in working hours, manageability, and marital status explained 33.8% of the variance in work safety attitudes.ConclusionThis study investigated the levels of burnout, SOC, and safety attitudes among nurses after COVID-19 in Chinese FSHs for the first time, and analyzed the associated factors. The results are valuable for improving the quality of nursing safety as well as patient safety management in FSHs.
Aconselhamento psicológico no hospital: reflexões sobre a prática em Unidade de Terapia Intensiva (UTI)
Authors: Possidônio Francisca Enislane Nascimento 
Published: February 2025

O presente estudo analisa as práticas de psicologia hospitalar em UTIs, com base na experiência de uma estagiária em psicologia hospitalar intensivista. Trata-se de uma pesquisa de natureza qualitativa, com abordagem exploratória, onde a entrevista semiestruturada foi utilizada como método de coleta de dados. A entrevista foi conduzida de forma online, seguindo um roteiro de perguntas elaborado com base no referencial teórico e nas questões de pesquisa previamente definidas pelos autores. As principais demandas psicológicas envolvem ansiedade, medo e incertezas, que afetam pacientes, familiares e equipes. Por meio do acolhimento, da escuta ativa e da terapia breve focal, o psicólogo promove suporte emocional e facilita a adaptação ao adoecimento. O artigo também discute os desafios estruturais e institucionais enfrentados pelos profissionais e propõe soluções para aprimorar o cuidado psicológico em ambientes hospitalares intensivos.
Analytical evaluation of output gain in photovoltaic-thermoelectric tandems
Authors: Sakuma Jun , Kamide Kenji , AKIYAMA Hidefumi 
Published: February 2025

Abstract
We analytically derived general requirements for photovoltaic (PV)–thermoelectric (TE) tandems gaining efficiencies beyond those of the original PV cells, and evaluated their output gain. We compared the derived gain-requirements equations with data of reported PV cells and TE devices, and showed that gain is practically possible with GaAs and thin c-Si PV cells in PV-TE generator (TEG) tandems but not in PV-TE cooler (TEC) tandems. We showed that combinations with BiTe TEGs can improve the efficiency of practical GaAs PV cells from 24% to 28.4% and that of ideal GaAs PV cells from 33% to 34.6%.
Marine-derived bioactive molecules as modulators of immune pathways: A molecular insight into pharmacological potential
Authors: Al-Hussaniy Hany A. , Mahan Sammar Jassim , Redha Zainab Mohamed , AlSaeedi Ahmed Hameed , Almukram Ali Majeed Ali , Oraibi Amjad I. , Abdalrahman Mostafa Adnan , Jabbar Alhasan Ali , Al-Ani Awatif A. Ibrahim , Hamed Hiba Ezzat , Jawad Mohammed Abed 
Published: February 2025

Background: Marine ecosystems are a vast reservoir of bioactive compounds with immense pharmacological potential.
Objectives: This review explores the molecular mechanisms of action, potential therapeutic applications, and challenges in the clinical translation of marine-derived bioactive molecules targeting immune pathways.
Methods: A comprehensive literature review was conducted, analyzing studies on the immunomodulatory effects of marine-derived polysaccharides, peptides, and secondary metabolites.
Result: In recent years, molecules derived from marine organisms, such as polysaccharides, peptides, and secondary metabolites, have shown promise as modulators of immune responses. These compounds interact with molecular pathways to enhance or suppress immune functions, making them valuable for treating diseases ranging from infections to autoimmune disorders and cancer.
Conclusion: Marine-derived bioactive compounds exhibit significant potential as immunomodulatory agents by targeting various immune pathways. However, further research is required to optimize their pharmacological applications and address challenges in clinical translation.
ReSurveyDunes — a data resource of resurveyed coastal dune vegetation plots in Italy
Authors: Acosta Alicia Teresa Rosario , Di Biase Letizia , Sarmati Simona , Allevato Emilia , Angiolini Claudia , Bagella Simonetta , Bazan Giuseppe , Bertacchi Andrea , Brancaleoni Lisa , Buffa Gabriella , Calbi Mariasole , Caria Maria Carmela , Ciccarelli Daniela , Cutini Maurizio , de Francesco Maria Carla , De Natale Antonino , Fantinato Edy , Fiaschi Tiberio , Gangale Carmen , Gerdol Renato , Gianguzzi Lorenzo , Laface Valentina Lucia Astrid , Maccherini Simona , Morabito Antonio , Mugnai Michele , Musarella Carmelo Maria , Pafumi Emilia , Santangelo Annalisa , Sciandrello Saverio , Siccardi Eugenia , Spampinato Giovanni , Stanisci Angela , Strumia Sandro , Viciani Daniele , Del Vecchio Silvia 
Published: February 2025

We present ReSurveyDunes — the first database of Italian coastal dune vegetation plots, developed through a collaborative network of Italian vegetation scientists. This paper describes the scope of the initiative, provides an overview of the available data, and highlights its key features, research applications, and future potential.
ReSurveyDunes currently comprises 972 vegetation plots distributed across 11 Italian regions (Abruzzo, Basilicata, Calabria, Campania, Emilia-Romagna, Lazio, Molise, Sardinia, Sicily, Tuscany, and Veneto). The original plots were surveyed between 1974 and 2009, with a primary focus on herbaceous psammophilous coastal zonation (habitats 1210, 2110, 2120, 2130*, 2210, 2230, and 2240, as defined by the 92/43/EEC Habitats Directive). Resurveys were conducted in 2023 and 2024. Each plot dataset includes (i) a complete list of vascular plant species with cover estimates; (ii) geographic coordinates (latitude and longitude); (iii) sampling dates; and (iv) plot size.
Designed to analyze fine-scale temporal trends in Italian coastal vegetation, ReSurveyDunes is a versatile tool for diverse ecological studies. It represents a valuable resource for evidence-based decision-making, enabling targeted conservation and management actions informed by up-to-date ecological data.
Effects of Orthokeratology in Patients With Convergence Insufficiency Exophoria and Myopia
Authors: Feng Yuelan , Wang Guangjiang , Wang Yuangyuan , Liang Xueming , Wang Yongsun , Zhang Wei 
Published: February 2025

Purpose
To observe and analyze the effects of orthokeratology in patients with convergence insufficiency, exophoria, and myopia.

Methods
Thirty patients (60 eyes) between 8 and 15 years old with myopia and convergence insufficiency exophoria treated with orthokeratology at the First Affiliated Hospital of the Baotou Medical College from December 2022 to December 2023 were prospectively enrolled. General information was gathered and examinations were performed at baseline and at 2 weeks and 1, 3, and 6 months after switching to orthokeratology lenses. Examinations included assessments of distance/near visual acuity, near point of convergence, distance and near horizontal phoria, near positive fusional vergence, and monocular amplitude of accommodation.

Results
The median age of the participants was 10 years (range: 8 to 15 years), and 40% were female. The baseline refractive error was −2.00 diopters (D) (range: −4.00 and −1.00 D). After 6 months of treatment, we found statistically significant differences in near point of convergence (95% confidence interval: −13.99 to −8.67), positive fusional vergence (95% confidence interval: 15.32 to 11.42), and monocular amplitude of accommodation (95% confidence interval: 6.62 to 4.51) compared with baseline. In addition, the mean pretreatment near horizontal phoria decreased from 6.83 ± 1.44 to −4.90 ± 1.29 prism diopters after the 6 months of treatment (95% confidence interval: −2.92 to −0.94).

Conclusions
This study showed that the use of orthokeratology lenses with an increased compression factor of 1.75 D may improve near point of convergence, positive fusional vergence, and monocular amplitude of accommodation for the treatment of convergence insufficiency with myopia.

[
J Pediatr Ophthalmol Strabismus
. 20XX;X(X):XXX–XXX.]
Reattachment of Fractured Fragment of Maxillary Central Incisor
Authors: Sivapriya K. S. , Jitha J. , Sreelekshmi V. , Nair Siddharth V. 
Published: February 2025

Abstract
One of the most commonly faced situations in clinical practice is dental trauma. Children and adolescents frequently report with uncomplicated/complicated crown fracture that requires immediate consideration. Clinicians should be efficient in treating such injuries and must be aware of the various treatment options available. Reattachment of tooth fragments should be the first choice and is a viable alternative to conventional approaches because of simpleness, natural aesthetics and less chairside time. Patient cooperation and understanding of the limitations of the treatment are of utmost importance for good prognosis. With recent developments in restorative materials, placement techniques, preparation designs and an adhesive protocol, the process of fragment reattachment has become conservative and more reliable. This article presents a case report describing the management of a complicated fracture of maxillary anterior teeth treated endodontically, followed by reattachment of the same fragment.
A Comparative Evaluation of Shear Bond Strength of Moisture Tolerant Pit and Fissure Sealant and Flowable Composite: An In vitro Study
Authors: Adapa Durga Satya Sai Kamakshi Amruthavarshini , Ayilliath Ambili , Ephraim Rena , Mridhul MU , Azhikoden Fazila 
Published: February 2025

Abstract

Background
The retention rate of a pit and fissure sealant is directly related to the micromechanical bond between the sealant and enamel. This research article aimed to assess the shear bond strength of moisture tolerant pit and fissure sealant and compare it with a flowable composite which is famed for its retention and strength.

Aim
To compare the shear bond strength of moisture tolerant pit and fissure sealant with flowable composite.

Materials and Methodology
Forty premolar teeth extracted for orthodontic purpose were randomly categorized into two equal groups with 20 samples each. Buccal/lingual enamel surface of the tooth was etched with 38% phosphoric acid for 20 s and Embrace wetbond sealant (EWS) and Estelite Flow Quick High Flow Flowable composite (EFC) as sealant was applied and cured. Shear load was applied using a universal testing machine and bond strength calculated in mega pascals (MPa) and tabulated. Statistical analysis was carried out using IBM SPSS and Mann–Whitney to compare the shear bond strength between the study groups. P ≤ 0.05 was considered as the level of significance.

Results
The Mann–Whitney test compared the shear bond strength values and it was found that EWS in vitro had a shear bond strength of 2.918 ± 0.7396 MPa. Comparative evaluation of the two showed a statistically significant value of P = 0.004*.

Conclusion
Moisture tolerant pit and fissure sealants have good shear bond strength which will ensure its retention on to the teeth especially in very young and specially abled children.
Поиски Императрицей Екатериной Великой (1762–1796) происхождения пугачевщины в истории Средневековья
Authors: Митрофанов А.Ю. 
Published: February 2025

Статья продолжает цикл публикаций автора, посвященных феномену самозванчества. Автор исследует восприятие пугачевщины Екатериной Великой (1762–1796) на примере сохранившихся писем Императрицы. Делаются выводы об отсутствии прямого участия Императрицы в убийствах Петра III и Иоанна Антоновича, но о косвенной причастности Екатерины к этим преступлениям, которые она могла предотвратить, о влиянии на политическую доктрину Екатерины древнерусских литературных образов из прочитанной ею «Повести Временных Лет», о характере восприятия Императрицей византийской цивилизации. Формулируется концепция автора, согласно которой дворцовые перевороты XVIII века, осуществлявшиеся петровской гвардией, являлись коррекцией абсолютизма, в то время как появления самозванцев в екатерининскую эпоху — Емельяна Пугачева, Лже-Иоаннов Антоновичей и княжны Таракановой — в определенной степени были не только следствием веры масс в «мужицкого царя», но и проявлением многовековой византийской политической традиции. Автор приходит к выводу, что Екатерина вдохновлялась в своей политической деятельности примерами политиков Древней Руси и искала истоки пугачевщины в эпохе татаро-монгольского ига.
The article continues the author’s series of publications devoted to the phenomenon of imposture. The author explores the perception of Pugachovism by Catherine the Great (1762–1796) using the example of preserved letters of the Empress. Conclusions are drawn about the absence of the Empress’s direct participation in the murders of Peter III and John Antonovich, but about the indirect involvement of Catherine II in these crimes, which she could have prevented, about the influence on the political doctrine of Catherine II of ancient Russian literary images from the “Tale of Bygone Years” read by the Empress, about the nature of the Empress’ perception of Byzantine civilization. The author’s concept is formulated, which consists in the fact that the palace coups of the XVIII century, carried out by the Peter’s Guard, were a correction of absolutism, while the appearance of impostors in the Catherine era: Yemelyan Pugachev, False John Antonovich and Princess Tarakanova to a certain extent were not only a consequence of the faith of the masses in the “peasant tsar”, but a manifestation of centuries-old Byzantine political tradition. It is concluded that Empress Catherine was inspired in her political activity by the examples of politicians of Ancient Russia and sought the origins of Pugachev in the era of the Tatar-Mongol yoke.