bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corneal Nerve Loss in Patients with Acute Ischemic Stroke: A Surrogate Marker for Poor Pial Collaterals
Authors: Khan Adnan , Menon Ajay , Akhtar Naveed , Kamran Saadat , Muhammad Ahmad , Ponirakis Georgios , Gad Hoda , Petropoulos Ioannis , Wadiwala Faisal , babu Blessy , Narangoli Adeeb , Bermejo Pablo , Hamad Hanadi Al , Ramadan Marwan , Woodruff Peter , Santos Mark , Saqqur Maher , Shuaib Ashfaq , Malik Rayaz A. 
Published: May 2021

Abstract
Background: In patients with ischemic stroke, pial collaterals play a key role in limiting neurological disability by maintaining blood flow to ischemic penumbra. We hypothesized that patient with poor pial collateral status will have greater corneal nerve and endothelial cell abnormalities.Method: 35 patients with acute ischemic stroke secondary to middle cerebral artery occlusion with poor (n=12) and moderate/good (n=23) pial collaterals and 35 healthy controls underwent corneal confocal microscopy and quantification of corneal nerve and endothelial cell morphology.Results: In patients with MCA stroke, corneal nerve fibre length (CNFL) (P=0.000), density (CNFD) (P=0.025) and branch density (CNBD) (P=0.002) were lower compared to controls. Age, BMI, cholesterol, triglycerides, HDL, LDL, systolic blood pressure, NIHSS and endothelial cell parameters did not differ but mRS was higher (p=0.023) and CNFL (p=0.026) and CNBD (p=0.044) were lower in patients with poor compared to moderate-good collaterals. CNFL and CNBD distinguished subjects with poor from good pial collaterals with an AUC of 72% (95% CI: 53-92%) and 71% (95% CI: 53-90%), respectively. Conclusion: Corneal nerve loss is greater in patients with poor compared to good pial collaterals and may act as a surrogate marker for pial collateral status in patients with ischemic stroke.
Association of molecular biomarkers heterogeneity and treatment pattern, disease outcomes in multifocal or multicentric breast cancer patients
Authors: Li Shuai , Wu Jiayi , Huang Ou , He Jianrong , Zhu Li , Chen Weiguo , Li Yafen , Chen Xiaosong , Shen Kunwei 
Published: May 2021

Abstract
Purpose

To evaluate the rates of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 heterogeneity in multifocal or multicentric breast cancer (MMBC) and its association with treatment pattern and disease outcomes.
Methods

MMBC patients with ER, PR, HER2, and Ki67 results for each tumor focus were retrospectively analyzed and categorized into the Homo group and the Hetero group. Chi-square test were performed to compare the treatment options between the groups. Disease-free survival (DFS) and overall survival (OS) rates were estimated from Kaplan-Meier curves and compared between two groups.
Results

A total of 330 patients were included and 53 (16.1%) were classified into the Hetero group. Adjuvant endocrine therapy was more frequently assigned for patients in the Hetero group than in the Homo group (84.9% vs. 71.7%, P = 0.046). There was no difference in terms of adjuvant anti-HER2 therapy (28.3% vs. 19.6%, P = 0.196) and chemotherapy (69.9% vs. 69.8%, P = 0.987) usage between two groups. At a median follow-up of 36 months, DFS rates were 81.2% for the Hetero group and 96.5% for the Homo group (HR = 2.81, 95% CI: 1.00-7.88, P = 0.041). The estimated 3-year OS rates for the groups were 95.8% and 99.5%, respectively (HR = 4.31, 95% CI: 0.83–22.46, P = 0.059).
Conclusion

Heterogeneity of ER, PR, HER2, or Ki67 was present in 16.1% patients with MMBC. Biomarkers heterogeneity influenced adjuvant endocrine therapy usage and was associated with worse disease outcomes, indicating further clinical evaluation.
MSA at 100 and why optical mineralogy still matters: The optical properties of talc
Authors: Gunter Mickey E. 
Published: May 2021

Abstract
MSA’s 100 years are memorialized herein with a combination of (1) events marking our centennial; (2) publications devoted to it; and (3) my series of six MSA president letters in Elements written specifically for this moment. In some of those letters, I stressed the importance of optical mineralogy and the role it played in areas outside of academics. As such, new optical data are presented herein on 20 well-characterized talc samples from other studies, as there appears to have been no thorough study of the optical properties of talc. Other than academic interest, these data will find use in the ongoing issue of the purported asbestos content of talc.
Parkinsonism-like Disease Induced by Rotenone in Rats: Treatment Role of Curcumin, Dopamine Agonist and Adenosine A2A Receptor Antagonist
Authors: Naser Asmaa Fathy Aboul , Aziz Wessam Magdi , Ahmed Yomna Rashad , Khalil Wagdy Khalil Bassaly , Hamed Manal Abdel Aziz 
Published: May 2021

Background:Parkinsonism is a neurodegenerative disorder that affects elderly people worldwide.Methods:Curcumin, adenosine A2AR antagonist (ZM241385) and Sinemet® (L-dopa) were evaluated against Parkinson’s disease (PD) induced by rotenone in rats, and the findings were compared to our previous study on mice model.Results:Rats injected with rotenone showed severe alterations in adenosine A2A receptor gene expression, oxidative stress markers, inflammatory mediator, energetic indices, apoptotic marker and DNA fragmentation levels as compared to the control group. Treatments with curcumin, ZM241385, and Sinemet® restored all the selected parameters. The brain histopathological features of cerebellum regions confirmed our results. By comparing our results with the previous results on mice, we noticed that mice respond to rotenone toxicity and treatments more than rats with regards to behavioral observation, A2AR gene expression, neurotransmitter levels, inflammatory mediator and apoptotic markers, while rats showed higher response to treatments regarding oxidative stress and energetic indices.Conclusion:Curcumin succeeded in attenuating the severe effects of Parkinson’s disease in the rat model and can be considered as a potential dietary supplement. Adenosine A2AR antagonist has almost the same pattern of improvement as Sinemet® and may be considered as a promising therapy against PD. To compare the role of animal species in response to PD symptoms and treatments, our previous report on mice explored the response of mice to rotenone toxicity in comparison with rats, where rats have shown a higher response to treatments. Therefore, no animal model can perfectly recapitulate all the pathologies of PD.
The Moderating Role of Parenting Styles in Adolescents’ Bullying and Depression
Authors: Klomek Anat Brunstein , Koren Kineret 
Published: May 2021

Background:
Bullying others among school-aged youth is a worldwide
phenomenon that has a variety of adverse outcomes, depression being one of them.

Objective:
The objective of the current study was to examine whether perceived
parenting styles moderated the relationship between bullying others and depression
among adolescents. It was hypothesized that perceived authoritarian parenting
would increase the association between bullying others and depression than nonauthoritarian
parents.

Methods:
The sample included 116 adolescents aged 12-17, with a mean age of
13.87. The percentage of male participants was 47.41%. We used self-report
questionnaires, which measured the different variables in the study (bullying,
perceptions of parenting styles, and depression).

Results:
A positive correlation between bullying others and depressive symptoms
was found. Bullying others and perceived authoritarian parenting style were also
correlated, and a positive correlation was found between perceived authoritarian
parenting style and depressive symptoms. The moderation effect of perceived
parenting style on the association between bullying others and depressive
symptoms was found significant. Among adolescents perceiving their parents as
authoritarian, the association between bullying others and depressive symptoms
was found to be stronger. In contrast, among adolescents perceiving their parents as
non-authoritarian, the association was low.

Conclusion:
Results of this study have important clinical implications by
understanding the parenting component in the association between bullying others
and depression. Our results suggest that the psychological outcomes for bullies may
depend, among other things, on their perception of parents' parenting style.
Virtual Reality for Sedation During Atrial Fibrillation Ablation in Clinical Practice: Observational Study
Authors: Roxburgh Thomas , Li Anthony , Guenancia Charles , Pernollet Patrice , Bouleti Claire , Alos Benjamin , Gras Matthieu , Kerforne Thomas , Frasca Denis , Le Gal François , Christiaens Luc , Degand Bruno , Garcia Rodrigue 
Published: May 2021

Background
Connected devices are dramatically changing many aspects in health care. One such device, the virtual reality (VR) headset, has recently been shown to improve analgesia in a small sample of patients undergoing transcatheter aortic valve implantation.

Objective
We aimed to investigate the feasibility and effectiveness of VR in patients undergoing atrial fibrillation (AF) ablation under conscious sedation.

Methods
All patients who underwent an AF ablation with VR from March to May 2020 were included. Patients were compared to a consecutive cohort of patients who underwent AF ablation in the 3 months prior to the study. Primary efficacy was assessed by using a visual analog scale, summarizing the overall pain experienced during the ablation.

Results
The AF cryoablation procedure with VR was performed for 48 patients (mean age 63.0, SD 10.9 years; n=16, 33.3% females). No patient refused to use the device, although 14.6% (n=7) terminated the VR session prematurely. Preparation of the VR headset took on average 78 (SD 13) seconds. Compared to the control group, the mean perceived pain, assessed with the visual analog scale, was lower in the VR group (3.5 [SD 1.5] vs 4.3 [SD 1.6]; P=.004), and comfort was higher in the VR group (7.5 [SD 1.6] vs 6.8 [SD 1.7]; P=.03). On the other hand, morphine consumption was not different between the groups. Lastly, complications, as well as procedure and fluoroscopy duration, were not different between the two groups.

Conclusions
We found that VR was associated with a reduction in the perception of pain in patients undergoing AF ablation under conscious sedation. Our findings demonstrate that VR can be easily incorporated into the standard ablation workflow.
Makanan dan Minuman yang Terdaftar di Bursa Efek Indonesia Periode 2015-2018
Authors: Mulyana I Kadek Rubi , Datrini Luh Kade , Sastri I.D.A.M. Manik 
Published: May 2021

Tujuan penelitian adalah untuk mengetahui Pengaruh Kinerja Keuangan Terhadap Return Saham Pada Perusahaan Makanan Dan Minuman Yang Terdaftar Di Bursa Efek Indonesia Periode 2015-2018. Jumlah sampel sebanyak 9 perusahaan selama periode 4 tahun, sehingga data berjumlah 36. Sumber data berasal dari data sekunder berupa laporan keuangan tahunan yang telah dikumpulkan dan dipublikasikan oleh website resmi Bursa Efek Indonesia (BEI). Teknik analisis data dengan analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa Current Ratio tidak berpengaruh terhadap Return Saham yang ditunjukkan dengan nilai signifikansi sebesar 0,492 lebih besar dari 0,05, maka H1 ditolak. Debt to Equity Ratio tidak berpengaruh terhadap Return Saham yang ditunjukkan dengan nilai signifikansi sebesar 0,691 lebih besar dari 0,05, maka H2 ditolak. Earning Per Share berpengaruh terhadap Return Saham yang ditunjukkan dengan nilai signifikansi sebesar 0,000 lebih kecil dari 0,05, maka H3 diterima. Return On Assets berpengaruh terhadap Return Saham yang ditunjukkan dengan nilai signifikansi sebesar 0,019 lebih kecil dari 0,05, maka H4 diterima.
KHAZANAH EKOLEKSIKON KEDANAUAN DALAM GUYUB TUTUR BAHASA BATAK TOBA
Authors: Sinaga Johandi , I Wayan Simpen  , Made Sri Satyawati  
Published: May 2021

This study aims to describe the ecolexicon treasures which represent the scope of Lake Toba. The ecolinguistic theory is used in this study. The data in this study are lexicons related to the scope of siltation. Data collection methods used are interview and observation methods. The analysis used a qualitative descriptive method. The results revealed 29 lexica related to the silt environment with three categories of ecolexicon entities namely flora ecolexicon, fauna ecolexicon, and fishing gear ecolexicon. The lexicon category consists of nouns and verbs. There are lexicon forms that are basic, derivative forms in the form of repeated words, and compound words.
Keywords: Fishing Gear; Lake Toba; Ekoleksikon; Fauna; Flora
PERANCANGAN MUTU BIOBRIKET MENGGUNAKAN TOOLS VALUE PROPOSITION CANVAS
Authors: Pradana Wibawa , Purnomo Dwi , Bunyamin Anas 
Published: May 2021

Biobriket menjadi salah satu produk yang dapat dihasilkan dari pemanfaatan kayu kaliandra dan limbah teh. Biobriket berbahan dasar kayu dan limbah teh ini merupakan hal baru, karena umumnya biobriket dibuat dari tempurung kelapa. Market testing diperlukan untuk mengetahui respon konsumen terhadap mutu dari biobriket yang dihasilkan. Respon konsumen nantinya digunakan untuk melakukan perancangan mutu biobriket agar dapat diterima konsumen dan memperluas pasar biobriket. Penelitian ini dilakukan menggunakan tools value proposition canvas dalam melakukan analisis respon konsumen untuk selanjutnya menjadi acuan dalam pembuatan biobriket.
PROMOSI PREVENTIF SADARI (PERIKSA PAYUDARA SENDIRI) DI DESA SAYANG SEBAGAI UPAYA PENCEGAHAN KANKER PAYUDARA
Authors: Muchtaridi Muchtaridi , Halimah Eli , Megantara Sandra , Wathoni Nasrul 
Published: May 2021

Menurut Data Globocan International Agency for Research on Cancer (IARC) pada tahun 2018, kanker payudara merupakan salah satu jenis kanker yang mempunyai prevalensi cukup tinggi dan penyebab utama kedua mortalitas di seluruh dunia sebesar 11,6% atau 2.089 juta jiwa dan morbiditas menempati urutan ke-5 sebesar 6,6% atau 627.000 juta jiwa. Di Indonesia, angka mortalitas kanker payudara menempati peringkat pertama sebesar 16,7% atau 58.256 juta jiwa dan angka morbiditas sebesar 11% atau 22.692 juta jiwa. Periksa Payudara Sendiri (Sadari) adalah pemeriksaan payudara yang dilakukan kita sendiri dengan belajar mandiri yaitu melihat dan memeriksa perubahan payudaranya sendiri setiap bulan. Pemeriksaan yang dilakukan secara berkala akan membantu mengetahui adanya benjolan atau bahkan masalah lain dari sejak awal walaupun masih berukuran kecil sehingga lebih efektif untuk diobati. Metode survei, pre-test, dan post test telah diterapkan sebagai upaya promosi Sadari ke ibu-ibu PKK Desa Sayang, Kecamatan Jatinangor, Sumedang. Masyarakat Desa Sayang dikatakan cukup tahu mengenai kanker payudara (68%), namun kurangnya informasi tentang pencegahan dini mengakibatkan kesadaran terhadap informasi kesehatan termasuk tentang pencegahan kanker payudara menjadi kurang (58,82 %). Hasil post test menunjukkan bahwa program promosi preventif Sadari meningkatkan pengetahuan dan kesadaran masyarakat sehingga disimpulkan bahwa masyarakat Desa Sayang perlu diberikan promosi secara berkala agar pengetahuan dan kesadaran meningkat dalam mencegah kanker payudara.
The Establishment of Târgu Mureș Branch of „Albina” Bank and the Relationships with its Headquarters in Sibiu (1919-1928)
Authors: Lenarth Raluca 
Published: May 2021

Abstract
A close look at the minutes of the Administration Council, a governing body of the „Albina” Bank in Sibiu, reveals various aspects, as important as they are interesting, regarding the activity of the Târgu Mureș branch (one of the most important branches that began its activity before the pre-war period - 1st May 1910).
After Transylvania was included in the Romanian Unitary National State, the entire economic life experienced a revival. In this context, „Albina”’s Târgu Mureș branch increased its turnorver beeing able to compete with the local credit institutions in the county, including the Saxon and Hungarian ones. However, the lack of liquidity on the financial markets, which threatened the well being of entire banking system, directly affected the branch starting with 1927/28. The examples found in archives and presented in this article emphasize a gradual decrease in the number of loans granted by the bank and the crippling effect on the local economy. Different types of loans are being explained and presented offering a vivid image of the inhabitants of the area, their nationality, their field of activity, which was directly linked with their financial abilities.
Some interesting, however controversial, aspects are being highlighted regarding the unorthodox practices of the personnel, the bold decisions of the director of the branch that were not exactly in the line with the code of conduct and the ethos promoted by „Albina”’s Headquarters in Sibiu.
Hormonal treatment with Ovopel increases sperm production in lake minnow, Eupallasella percnurus (Pallas, 1814)
Authors: Kamiński Rafał , Judycka Sylwia , Sikorska Justyna , Wolnicki Jacek 
Published: May 2021

Abstract
The aim of the study was to determine the suitability of Ovopel, which contains an mGnRH analog and metoclopramide (a dopamine inhibitor), for the stimulation of spermiation in the cyprinid fish lake minnow, Eupallasella percnurus (Pallas), which is endangered with extinction in Poland. The hormonal treatment effected an approximate twofold increase in sperm volume with a simultaneous decrease in sperm concentration and negligible differences in motility and straight-line velocity.
The Emergence of New States in Eastern Europe after World War I: The German Impact
Authors: Ziemer Klaus 
Published: May 2021

Abstract
After World War I, many borders in Europe were redrawn, especially in the northeast and southeast of Germany. Almost all political forces in Germany strived to restore the prewar German borders, especially towards Poland. Even Poland’s very existence was denied by many German political forces. The Baltic States were less important for Germany in this respect. Here the relationship with the Baltic Germans and trade relations prevailed. The independence of these states was in the eyes of German elite subordinated to the relations with Russia. The article presents this pattern of German policy until the Treaty of Rapallo in 1922.
Interpretable Machine-Learning Approach in Estimating FDI Inflow: Visualization of ML Models with LIME and H2O
Authors: Singh Devesh 
Published: May 2021

Abstract
In advancement of interpretable machine learning (IML), this research proposes local interpretable model-agnostic explanations (LIME) as a new visualization technique in a novel informative way to analyze the foreign direct investment (FDI) inflow. This article examines the determinants of FDI inflow through IML with a supervised learning method to analyze the foreign investment determinants in Hungary by using an open-source artificial intelligence H2O platform. This author used three ML algorithms—general linear model (GML), gradient boosting machine (GBM), and random forest (RF) classifier—to analyze the FDI inflow from 2001 to 2018. The result of this study shows that in all three classifiers GBM performs better to analyze FDI inflow determinants. The variable value of production in a region is the most influenced determinant to the inflow of FDI in Hungarian regions. Explanatory visualizations are presented from the analyzed dataset, which leads to their use in decision-making.
Review of Landfills in Europe Accordind to the European Commissin’s Policy Identifying Effective Criteria for Reducind, Reusing, and Proposing Waste Levels in the Construction Sector
Authors: Ahmadi H. Babaeyan , Sánchez-Torija J. Gallego 
Published: May 2021

AbstractConstruction waste makes up a large part of the waste produced in Europe. Therefore, the European Commission has developed policies to create an economic cycle and increase waste recycling. These solutions have been developed reduce the destructive effects of the environment, including various certificates such as LEED in different countries to encourage building debris management. However, not all construction waste can be recycled and reused, often buried in the environment. Although these wastes are extracted from natural resources, the process of making them changes their original nature, and it is not possible to estimate the exact time of their decomposition and reversibility of waste in nature. Thus, a large part of them is landfilled due to their Non-Recyclability. Moreover, every year, a large area of fertile and usable land is allocated for their burial. This paper aims to clarify the non-recyclable part of landfilled construction waste in the environment, highlighting the need for importance and research in this area. It can improve and preserve the sources, land, and health of the environment and human beings in EU member states threatened by landfilling.
Hydro-Sedimentary Study of a Tidal River: Case Study of the Arvand River in Iran
Authors: Bakhtiari M. , Larki A. Ashtari , Samer A. 
Published: May 2021

Abstract
The present field study investigated hydraulic and sediment in tidal conditions. Measurements were made for two stations at neap tide and spring tide for 13-hour periods at no-dimensional depths of 0.2, 0.6 and 0.8 of the water level each time. In these measurements, the parameters of velocity, direction of flow, electrical conductivity, temperature and depth were measured directly, and to determine the amount of suspended sediments per hour, 3 samples of one litre from the mentioned depths were measured by the instantaneous vertical sampler and taken to a laboratory. An examination of the depth charts of the suspended sediments concentration for all stations, and in both the neap tide and the spring tide, showed that, in general the suspended sediments concentration increased with increasing depth. Moreover, the deep distribution of sediments concentration showed that the values obtained in the laboratory corresponded well with the values calculated from the Rouse equation, and as the depth increases, the sediments concentration usually increases.
Influence of the Central City on the Location of Commercial Buildings in the Agglomeration. The Example of Krakow, Poland
Authors: Dębińska Ewa , Pałubska Joanna A. 
Published: May 2021

Abstract
Shaping the spatial policy belongs to the tasks of the local commune governments, which through the acts of local law in the form of local spatial development plans establish rules of land development for specific purposes. Analyzing properties which are not significantly diversified in terms of location, because they belong to the same area of the “local market”, it can be concluded that linking land properties with the functions they can perform and with their development possibilities is the most significant attribute which shapes the level of land value. Suburbanization processes influence the decisions of communes located in the immediate vicinity of urban agglomerations as to the directions of allocating land for specific purposes, especially in the areas within the city’s range of influence. The subject of the research is real estates with commercial, service and industrial functions located in the district of Krakow, within the boundaries of communes directly adjacent to Krakow. The aim of the works is to analyze the links between the location of areas designated for commercial development and the location of main communication routes and the distance from the city borders.