bluuebunny/crossref_metadata_2025_split huggingface dataset:
Domestic and international climate policies: complementarity or disparity?
Authors: Peterson Lauri 
Published: June 2021

AbstractClimate change is a global crisis that requires countries to act on both domestic and international levels. This paper examines how climate policies in these two arenas are related and to what extent domestic and international climate ambitions are complementary or disparate. While scholarly work has begun to assess the variation in overall climate policy ambition, only a few studies to date have tried to explain whether internationally ambitious countries are ambitious at home and vice versa. According to the common view, countries that are more ambitious at home can also be expected to be more ambitious abroad. Many scholars, however, portray the relationship instead as disparate, whereby countries need to walk a tightrope between the demands of their domestic constituencies on the one hand and international pressures on the other, while preferring the former over the latter. This study uses quantitative methods and employs data from the OECD DAC dataset on climate finance to measure international climate ambitions. Overall, the present work makes two major contributions. First, it provides evidence that international climate financing ambition is complementary to domestic climate ambition. Second, the article identifies the conditional effect of domestic ambition—with regard to responsibility, vulnerability, carbon-intensive industry and economic capacity—on international climate ambition.
A Balancing Act: Working and Caring for a Child with Cancer
Authors: Hjelmstedt Sofia K. , Forinder Ulla M. , Lindahl Norberg Annika M. , Hovén Emma I. M. 
Published: June 2021

AbstractParenting a child with cancer creates numerous additional care demands that may lead to increased difficulties in balancing work and family responsibilities. Still, there is limited knowledge of how parents cope with both parenthood and paid work after a child’s cancer diagnosis. The aim of the study was to explore mothers’ and fathers’ experiences of balancing the dual roles of work and parenthood following a child’s cancer diagnosis. Nine focus groups with in total 32 parents of children with cancer in Sweden were conducted. The data was analysed using qualitative content analysis. Three categories were identified: Shifts in the importance of the parent role and the work role, Influence of context and conditions on the balance of roles, and Long-term unbalance of roles. Parents expressed an increased appreciation of time spent with family, but also emphasized the importance of work to counterbalance the sometimes overwhelming parenting demands. The pre-existing financial situation, work situation, and employer behaviour were important factors influencing the parents’ ability to balance work and family. Traditional gender roles influenced how couples divided responsibilities and reflected on their experiences. Mothers and fathers were also met with different expectations, which highlights the need for the healthcare to consider their communication with caregivers. Importantly, the parents expressed how the child’s illness affected their ability to balance work and family for a long time, while the understanding and support from others had steadily declined. Enabling parents to care for their ill child without sacrificing their own career is of utmost importance, and future research should focus on identifying which factors facilitate for parents to achieve a sustainable work-life balance.
Enlargement of apartments in socialist housing estates in Skopje under transition: The tension between individual preferences and collective action
Authors: Mariotti Jasna , Hess Daniel Baldwin 
Published: June 2021

AbstractThe post-socialist urban restructuring of Skopje, North Macedonia has been characterized by significant changes in the built fabric of the city, resulting from the political, economic and societal processes following the dissolution of Yugoslavia. In early 1990s and post-privatization, there was a dynamic transformation of the city’s housing stock in post-WWII prefabricated apartment buildings. Flat owners in socialist-era housing estates in Skopje modified their apartments by expanding and enclosing balconies, thus gaining more living space. Garages were converted into shops and ground-floor and first-floor apartments were renovated into offices, resulting in commercialization of previous residential space. To better understand the spatial disorder triggered by transformation of housing estates during the lengthy transition from a centrally-planned system to a market economy, this article evaluates various spontaneous and planned practices of transformation of residential space in housing estates in post-socialist Skopje. We analyze these changing practices of transformation through fieldwork and focus group discussions with residents. We also review archival material and administrative and legal documents, including municipal master plans and national planning laws and decisions related to housing estates in post-1991 Skopje. Findings emphasize the complex interplay between many actors, ideologies and interests that shape the experience of urban life in post-socialist Skopje, evidenced by outcomes related to housing choice and renovation practice, especially the enclosure of balconies for providing more living space. Such interventions are viewed as important steps towards improving living conditions in prefabricated apartment buildings in Skopje. Individual decisions about apartment renovation affect urban planning at the neighborhood level, and the findings from this research thus inform residential mobility and neighborhood-level strategic decision making. The aim is to help neighborhoods—built in an earlier socio-political era under a central planning system—to adapt to future demands.
Metal salts as dopants for ZnO ceramics-thermogravimetry coupled with mass spectrometry studies
Authors: Wiecinski Piotr , Wieclaw-Midor Anna 
Published: June 2021

AbstractThe paper presents results concerning thermal decomposition of copper II salts (acetylacetonate, acetate monohydrate and nitrate trihydrate) in synthetic air and argon flow. Thermogravimetry tests coupled with mass spectrometry were performed in temperature range of 25–1300 °C. The influence of salt addition on the rheological properties and sintering behaviour of ceramic samples was then investigated. The microstructure evolution based on light and scanning electron microscopies coupled with stereological methods was described. The performed investigations revealed not only the differences in thermal decomposition of examined salts but also differences in the phenomena related to the oxidation and reduction processes of copper products. The atmosphere has also influenced the mechanisms of salts decomposition as well as further changes in decomposition products. Moreover, the presence of ZnO powder has changed the thermal decomposition process of copper II acetylacetonate. The investigations showed that acetates and nitrates can be efficient in homogeneous distribution of small amounts of metal additives in the ZnO-based suspensions. Higher concentrations of these type of salts lead to the increase of viscosity due to the fact that acetates and nitrates increase the ionic strength in the slurry. On the other hand, acetylacetonates do not disturb the stability of the slurries. However, they are characterized by low water solubility and thus homogenous distribution of small amount of these dopants is more difficult. The addition of copper increased the grain size of the sintered ZnO samples. The copper was not segregated at grain boundaries in the form of oxide, it diffused into ZnO matrix.
Consequences of ignoring variable and spatially autocorrelated detection probability in spatial capture-recapture
Authors: Moqanaki Ehsan M. , Milleret Cyril , Tourani Mahdieh , Dupont Pierre , Bischof Richard 
Published: June 2021

AbstractContextSpatial capture-recapture (SCR) models are increasingly popular for analyzing wildlife monitoring data. SCR can account for spatial heterogeneity in detection that arises from individual space use (detection kernel), variation in the sampling process, and the distribution of individuals (density). However, unexplained and unmodeled spatial heterogeneity in detectability may remain due to cryptic factors, both intrinsic and extrinsic to the study system. This is the case, for example, when covariates coding for variable effort and detection probability in general are incomplete or entirely lacking.ObjectivesWe identify how the magnitude and configuration of unmodeled, spatially variable detection probability influence SCR parameter estimates.MethodsWe simulated SCR data with spatially variable and autocorrelated detection probability. We then fitted an SCR model ignoring this variation to the simulated data and assessed the impact of model misspecification on inferences.ResultsHighly-autocorrelated spatial heterogeneity in detection probability (Moran’sI= 0.85–0.96), modulated by the magnitude of the unmodeled heterogeneity, can lead to pronounced negative bias (up to 65%, or about 44-fold decrease compared to the reference scenario), reduction in precision (249% or 2.5-fold) and coverage probability of the 95% credible intervals associated with abundance estimates to 0. Conversely, at low levels of spatial autocorrelation (median Moran’sI= 0), even severe unmodeled heterogeneity in detection probability did not lead to pronounced bias and only caused slight reductions in precision and coverage of abundance estimates.ConclusionsUnknown and unmodeled variation in detection probability is liable to be the norm, rather than the exception, in SCR studies. We encourage practitioners to consider the impact that spatial autocorrelation in detectability has on their inferences and urge the development of SCR methods that can take structured, unknown or partially unknown spatial variability in detection probability into account.
Cloning and Functional Analysis of Rat Tweety-Homolog 1 Gene Promoter
Authors: Gorniak-Walas Malgorzata , Nizinska Karolina , Lukasiuk Katarzyna 
Published: June 2021

AbstractTweety-homolog 1 protein (Ttyh1) is abundantly expressed in neurons in the healthy brain, and its expression is induced under pathological conditions. In hippocampal neurons in vitro, Ttyh1 was implicated in the regulation of primary neuron morphology. However, the mechanisms that underlie transcriptional regulation of the Ttyh1 gene in neurons remain elusive. The present study sought to identify the promoter of the Ttyh1 gene and functionally characterize cis-regulatory elements that are potentially involved in the transcriptional regulation of Ttyh1 expression in rat dissociated hippocampal neurons in vitro. We cloned a 592 bp rat Ttyh1 promoter sequence and designed deletion constructs of the transcription factors specificity protein 1 (Sp1), E2F transcription factor 3 (E2f3), and achaete-scute homolog 1 (Ascl1) that were fused upstream of a luciferase reporter gene in pGL4.10[luc2]. The luciferase reporter gene assay showed the possible involvement of Ascl1, Sp1, and responsive cis-regulatory elements in Ttyh1 expression. These findings provide novel information about Ttyh1 gene regulation in neurons.
Elaborated subloading surface model for accurate description of cyclic mobility in granular materials
Authors: Hashiguchi Koichi , Mase Tatsuya , Yamakawa Yuki 
Published: June 2021

AbstractThe description of the cyclic mobility observed prior to the liquefaction in geomaterials requires the sophisticated constitutive formulation to describe the plastic deformation induced during the cyclic loading with the small stress amplitude inside the yield surface. This requirement is realized in the subloading surface model, in which the surface enclosing a purely elastic domain is not assumed, while a purely elastic domain is assumed in other elastoplasticity models. The subloading surface model has been applied widely to the monotonic/cyclic loading behaviors of metals, soils, rocks, concrete, etc., and the sufficient predictions have been attained to some extent. The subloading surface model will be elaborated so as to predict also the cyclic mobility accurately in this article. First, the rigorous translation rule of the similarity center of the normal yield and the subloading surfaces, i.e., elastic core, is formulated. Further, the mixed hardening rule in terms of volumetric and deviatoric plastic strain rates and the rotational hardening rule are formulated to describe the induced anisotropy of granular materials. In addition, the material functions for the elastic modulus, the yield function and the isotropic hardening/softening will be modified for the accurate description of the cyclic mobility. Then, the validity of the present formulation will be verified through comparisons with various test data of cyclic mobility.
Validity and reliability of innovative field measurements of tibial accelerations and spinal kinematics during cricket fast bowling
Authors: Senington Billy , Lee Raymond Y. , Williams Jonathan Mark 
Published: June 2021

AbstractThe use of inertial sensors in fast bowling analysis may offer a cheaper and portable alternative to current methodologies. However, no previous studies have assessed the validity and reliability of such methods. Therefore, this study aimed to assess the validity and reliability of collecting tibial accelerations and spinal kinematics using inertial sensors during in vivo fast bowling. Thirty-five elite male fast bowlers volunteered for this study. An accelerometer attached to the skin over the tibia was used to determine impacts and inertial sensors over the S1, L1 and T1 spinous processes used to derive the relative kinematics. These measurements were compared to optoelectronic and force plate data for validity analysis. Most acceleration and kinematics variables measured report significant correlations > 0.8 with the corresponding gold standard measurement, with intraclass correlation coefficients greater than 0.7. Low standard error of measurement and consequently small minimum detectable change (MDC) values were also observed. This study demonstrates that inertial sensors are as valid and reliable as current methods of fast bowling analysis and may provide some advantages over traditional methods. The novel metrics and methods described in this study may aid coaches and practitioners in the design and monitoring of fast bowling technique.
Graphical abstract

Graphical abstract illustrating the synopsis of the findings from this paper.
COVID-19 Infection and Circulating Microparticles—Reviewing Evidence as Microthrombogenic Risk Factor for Cerebral Small Vessel Disease
Authors: Che Mohd Nassir Che Mohd Nasril , Hashim Sabarisah , Wong Kah Keng , Abdul Halim Sanihah , Idris Nur Suhaila , Jayabalan Nanthini , Guo Dazhi , Mustapha Muzaimi 
Published: June 2021

AbstractSevere acute respiratory syndrome corona virus-2 (SARS-CoV-2) due to novel coronavirus disease 2019 (COVID-19) has affected the global society in numerous unprecedented ways, with considerable morbidity and mortality. Both direct and indirect consequences from COVID-19 infection are recognized to give rise to cardio- and cerebrovascular complications. Despite current limited knowledge on COVID-19 pathogenesis, inflammation, endothelial dysfunction, and coagulopathy appear to play critical roles in COVID-19-associated cerebrovascular disease (CVD). One of the major subtypes of CVD is cerebral small vessel disease (CSVD) which represents a spectrum of pathological processes of various etiologies affecting the brain microcirculation that can trigger subsequent neuroinflammation and neurodegeneration. Prevalent with aging, CSVD is a recognized risk factor for stroke, vascular dementia, and Alzheimer’s disease. In the background of COVID-19 infection, the heightened cellular activations from inflammations and oxidative stress may result in elevated levels of microthrombogenic extracellular-derived circulating microparticles (MPs). Consequently, MPs could act as pro-coagulant risk factor that may serve as microthrombi for the vulnerable microcirculation in the brain leading to CSVD manifestations. This review aims to appraise the accumulating body of evidence on the plausible impact of COVID-19 infection on the formation of microthrombogenic MPs that could lead to microthrombosis in CSVD manifestations, including occult CSVD which may last well beyond the pandemic era.
The mediating role of narcissism in the effects of regulatory mode on positivity
Authors: Di Santo Daniela , Lo Destro Calogero , Baldner Conrad , Talamo Alessandra , Cabras Cristina , Pierro Antonio 
Published: June 2021

AbstractPositivity (i.e., the individual tendency to positively approach life experiences) has proven to be an effective construct applied in positive psychology. However, individuals’ self-regulation may have contrasting effects on positivity. We specifically examined whether positivity could be partially explained through two aspects of motivation concerned with self-regulation: locomotion (i.e., a motivational orientation concerned with movement) and assessment (i.e., a motivational orientation concerned with comparison and evaluation). Furthermore, based on previous literature that found a link between these aspects and narcissism, we examined whether “adaptive” and “maladaptive” dimensions of narcissism could mediate the effects of locomotion and assessment on increased or decreased positivity. Narcissism was defined by previous research as adaptive or maladaptive insofar as it leads or does not lead to increased psychological well-being. We estimated a mediation model with multiple independent variables and multiple mediators in a cross-sectional study with self-reported data from 190 university students. We found that both locomotion and assessment were associated with adaptive narcissism, which in turn was positively associated with positivity. However, assessment was also associated with maladaptive narcissism, which in turn was negatively associated with positivity. Relationships between aspects of self-regulation, narcissism, and positivity can have significant implications which will be discussed.
Mitochondrien unter Stress: Die Rolle der Präsequenzprotease MPP
Authors: Vögtle F.-Nora 
Published: June 2021

AbstractThe majority of mitochondrial proteins are encoded in the nuclear genome, so that the nearly entire proteome is assembled by post-translational preprotein import from the cytosol. Proteomic imbalances are sensed and induce cellular stress response pathways to restore proteostasis. Here, the mitochondrial presequence protease MPP serves as example to illustrate the critical role of mitochondrial protein biogenesis and proteostasis on cellular integrity.
Multifunktionale bakterielle Nanomagnete für Biotechnologie und Medizin
Authors: Mickoleit Frank , Rosenfeldt Sabine , Schenk Anna S. , Schüler Dirk , Uebe René 
Published: June 2021

AbstractBacterial magnetosomes represent magnetic core-shell nanoparticles biomineralized by magnetotactic bacteria like Magnetospirillum gryphiswaldense. The establishment of fermentation regimes for high-yield particle production, standardized isolation procedures as well as the development of a genetic toolkit for the generation of “tailored” particles might soon pave the way for the application of engineered magnetosomes in the biomedical and biotechnological field.
Implantatüberzüge für die in situ-Transfektion in der regenerativen Medizin
Authors: Husteden Catharina , Groth Thomas , Wölk Christian 
Published: June 2021

AbstractA promising approach in regenerative medicine is to modify cell behaviour with growth factors. However, the side of action has to be in spatial control. We present a new strategy in the field of regenerative medicine based on the combination of implant coatings with nanoscaled gene vectors. This enables the local restricted in situ transfection of cells to induce the production of cytokines. Therewith, the migration and differentiation of cells can be controlled to support tissue regeneration.
SARS-CoV-2 Nsp1: Ein kleines Protein blockiert die Immunantwort
Authors: Sparrer Konstantin , Kirchhoff Frank 
Published: June 2021

AbstractThe Coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To facilitate its own replication and avoid immune control, SARS-CoV-2 manipulates its target cells. Our results revealed that the SARS-CoV-2 non-structural protein 1 (Nsp1) plays a key role in viral immune evasion. It blocks the mRNA tunnel of the cellular ribosome, resulting in a shutdown of translation and strong attenuation of the host’s antiviral immune response.
Zelluläres Tauziehen: Wie Zellen auf mechanischen Stress antworten
Authors: Weissenbruch Kai , Hippler Marc , Bastmeyer Martin 
Published: June 2021

AbstractThe ability of cells to sense and respond to extracellular forces is critical for cellular and tissue homeostasis. Tension or compression act on our body ubiquitously and cells respond to such mechanical cues by producing intracellular forces on their own. In this article, we briefly highlight the cellular and physical basis driving these phenomena and discuss our recent technical advance to stimulate and monitor the cellular mechanoresponse on a molecular scale.
mRNA-Strukturen steuern die posttranskriptionelle Genregulation
Authors: Lichtenthaeler Chiara , Oberstrass Lasse , Weigand Julia E. 
Published: June 2021

AbstractPosttranscriptional regulation at mRNA level is defined not only by sequence, but also by the structure of the mRNA. Structures in the untranslated regions control stability, translation and localization of an mRNA. Evolutionary conservation can be used to identify such regulatory active structures in mRNAs. For example, constitutive decay element (CDE) stem-loops are recognized by Roquin proteins in an exclusively shape-specific manner. Strikingly, some CDEs can serve a dual function in gene repression depending on their folding status.
Funktion rätselhafter Retrons entschlüsselt
Authors: Bobonis Jacob , Mitosch Karin , Typas Athanasios 
Published: June 2021

AbstractVAAM-Forschungspreis 2021Bacterial retrons are operons containing reverse transcriptases. Despite three decades of research, their physiological role remained mysterious. Recently, retrons have been uncovered as a widespread novel class of antiphage defense systems. We here discuss how high-throughput reverse genetics have enabled this discovery, illustrating the power such approaches have to illuminate the function of uncharacterized genes.
Analysis of Influencing Factors of College Students’ Intention to Repeated Blood Donation Based on Structural Equation Modeling
Authors: Pan Lingling , Hu Wei , Han Wenjuan , Wang Yingying 
Published: June 2021

AbstractTo research the influencing factors of college students' blood donation behavior intention and propose intervention strategies to improve the repeated blood donation rate of college students. Questionnaire survey was used to research and analyze the influencing factors of behavior intention. Amos 21.0 software was used to establish structural equation modeling and perform confirmatory factor analysis. SPSS 20.0 was used for statistic. The model was proved with highly adaptability, with χ2/df = 2.956 < 3. Factors influencing college students' intention of repeat blood donation behavior can be summarized into four: attitude, external motivation, advice-taking, and perceived behavioral control. Among them, attitude and perceived behavioral control have a great direct impact on behavioral intention, while the external motivation and recommendation acceptance have an indirect impact by influencing the other two factors. In view of those evaluation items with high path coefficient in each factor, we can develop recruitment strategies to influence college students’ repeated blood donation behavior and provide scientific suggestions for improving their repeated blood donation rate.