bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification and Characterization of the Y‐Organ of Orange Mud Crab Scylla Olivacea
Authors: Achdiat Muhammad , Fujaya Yushinta , Fazhan Hanafiah , Rozaimi Rusydi , Chung J. Sook , Wang Youji , Tan KianAnn , Shu‐Chien Alexander Chong , Maulidiani M. , Waiho Khor 
Published: December 2024

ABSTRACTThe Y‐organs (YOs) synthesize and secrete molting hormones, and thus regulate crustacean growth and reproduction. However, the YOs of the orange mud crab Scylla olivacea is yet to be described due to its minute size and ambiguous feature. This study describes the location, morphological characteristics, histology, and the changes of YOs at different molt stages, and examines in vitro ecdysteroid secreted by the YOs of S. olivacea. Mature male crabs (> 90 mm carapace width, CW) were used to identify the location of the YOs while male juveniles (50–65 mm CW) at three molt stages (intermoult, premoult, postmoult) were dissected for the characterization of 20‐Hydroxyecdysone (20E) levels. The yellowish‐white, compact, and oval‐shaped YOs are located in pairs at the anterior cephalothorax region, beneath the mandibular external adductor muscle, anterior to the branchial chamber space, and around the end of the nerve tract. The YOs index and YO's cell diameter increased from postmoult to premoult; YO's diameter increased only during premoult stage. Under electron microscopy, the YO's surface morphology is rough, bumpy, network‐like, and porous, with several lacunar system tubules. High concentrations of haemolymph 20E during premoult correlated with the changes in the characteristics of YOs at this stage. The presence of ecdysteroid in YOs was confirmed by high performance liquid chromatography (HPLC). The characteristics of the YOs of S. olivacea are similar to the YO descriptions of other brachyurans. The successful identification and characterization of YOs will spearhead future research on understanding its role in molt regulation of mud crabs, consequently contributing to the development and progress of crab culture and soft‐shell crab industries.
The safety and feasibility of robotic pancreaticoduodenectomy: A multicenter retrospective assessment of 425 patients in Japan
Authors: Nakamura So , Nakata Kohei , Nagakawa Yuichi , Kozono Shingo , Wakabayashi Go , Wakabayashi Taiga , Uyama Ichiro , Takahara Takeshi , Takeda Yutaka , Ohmura Yoshiaki , Ko Saiho , Nishioka Ayumi , Kiritani Sho , Inoue Yosuke , Adachi Tomohiko , Eguchi Susumu , Morimoto Mamoru , Matsuo Yoichi , Kurahara Hiroshi , Ohtsuka Takao , Nakamura Masafumi 
Published: December 2024

AbstractBackground/PurposeThe Japanese public health insurance system has recently covered robotic pancreaticoduodenectomy (RPD). This study aimed to review the results of RPD during the introductory period and elucidate its safety and feasibility in Japan.MethodsConsecutive data of 425 patients who underwent RPD were retrospectively collected from 10 high‐volume centers in Japan between April 2020 and September 2022. The primary endpoints were the rates of conversion to open surgery and completion of minimally invasive surgery (MIS), defined as the use of a totally robotic operation or combined robotic and laparoscopic procedures. Secondary endpoints were operative time, blood loss, complication rate, and 30‐ and 90‐day mortality rates.ResultsStudy comprised 222 males and 203 females, with a median age of 70 (p10–p90; 50–81) years. The conversion to open surgery and completion rates of MIS were 3.8% (16 patients) and 91.1% (387 patients), respectively. The median operative time was 617 min (p10–p90; 456–834 min), and the median volume of blood loss was 160 g (p10–p90; 30–558 g). The complication rate (Clavien‐Dindo classification grade ≥ IIIa) was 20.5%. The 30‐ and 90‐day mortality rates were 0.2% and 0.5%, respectively.ConclusionsOur results indicate that RPD can be introduced successfully and is a promising approach for pancreaticoduodenectomy.
Emotional intelligence evaluation tools used in allied health students: A scoping review
Authors: Lee Debra , Burrows Tracy , James Daphne , Wilkinson Ross , Surjan Yolanda 
Published: December 2024

AbstractIntroductionEmotional intelligence (EI) is described as the ability to recognise and understand one's own emotions and the emotions of others, and empathically manage emotional responses. While historically not emphasised in undergraduate allied health sciences training, it is increasingly considered an essential graduate trait. This scoping review synthesises existing research on EI outcomes, specifically in undergraduate allied health professions students.MethodFour databases were searched in February 2024 using keywords relating to EI and empathy to identify studies published in English from 1990. Eligible studies needed to include assessment and reported outcomes using validated EI tools in health professions students.ResultsA total of 163 papers met the inclusion criteria. Many studies employed a cross‐sectional design (n = 115). Most studies (n = 135) focused on undergraduate students studying medicine (n = 62), nursing (n = 80) and dentistry (n = 13), with some studies (n = 21) evaluating more than one discipline. Many studies investigated one discipline only (n = 64 for nursing, n = 50 for medicine) using no comparator undergraduate degree. The most common EI models evaluated from this review were ability‐based (n = 77), followed by trait‐based models (n = 36) and mixed social–emotional competence (n = 35). Ability model evaluations of EI most commonly utilised the Schutte Self‐Report Emotional Intelligence Test (SSEIT) (n = 44) and the Mayer–Salovey–Caruso Emotional Intelligence Test (MSCEIT) (n = 24).ConclusionResearch on EI among undergraduate allied health fields is limited. Existing literature reveals there is some consensus on the importance of EI in healthcare education, but there is considerable variability in how EI is measured. Studies suggest higher levels of EI may correlate with improved student professional skill development in clinical reasoning, empathy and stress management.
A Novel Circular Delta‐XBB.1.5 RBD Dimeric Protein Subunit Vaccine Mediated by Split Intein Elicits an Immune Response and Protection Against Multiple SARS‐CoV‐2 Variants in Mice
Authors: Li Kangyin , Wu Yan , Zhang Hongqing , Chen Shaohong , Wu Bihao , Li Tingting , Li Entao , Luo Feiyang , Jin Aishun , Zhang Bo , Zhang Yanan , Gong Rui , Zhang Huajun , Chiu Sandra 
Published: December 2024

ABSTRACTSARS‐CoV‐2 continues to mutate, leading to breakthrough infections. The development of new vaccine strategies to combat various strains is crucial. Protein cyclization can enhance thermal stability and may improve immunogenicity. Here, we designed a cyclic tandem dimeric receptor‐binding domain protein (cirRBD2) via the split intein Cth‐Ter. Cyclization does not affect the antigen epitopes of RBD but results in better thermal stability than that of its linear counterpart (linRBD2). Compared with the mice immunized with linRBD2, those immunized with two doses of 5 μg of cirRBD2 produced significantly greater levels of broad‐spectrum neutralizing antibodies, and generated a considerable cellular immune response. In the VEEV‐VRP‐hACE2‐transduced mouse model, two doses of 5 μg of cirRBD2 provided protection against infection with BA.5, XBB.1.9, and partial protection against EG.5 which has more mutations. This study developed a novel circular RBD dimer subunit vaccine for SARS‐CoV‐2 that exhibits broad‐spectrum neutralizing activity against various variants. A similar strategy can be applied to develop vaccines for other pathogens, especially for thermally stable vaccines.
Oligodendrocytes in Huntington's Disease: A Review of Oligodendrocyte Pathology and Current Cell Reprogramming Approaches for Oligodendrocyte Modelling of Huntington's Disease
Authors: Back Amelie Marie , Connor Bronwen , McCaughey‐Chapman Amy 
Published: December 2024

ABSTRACTHuntington's disease (HD) is an autosomal dominant neurodegenerative disorder traditionally characterized by the selective loss of medium spiny neurons in the basal ganglia. However, it has become apparent that white matter injury and oligodendrocyte dysfunction precede the degeneration of medium spiny neurons, garnering interest as a key pathogenic mechanism of HD. Oligodendrocytes are glial cells found within the central nervous system involved in the production of myelin and the myelination of axons. Myelin is a lipid‐rich sheath that wraps around axons, facilitating signal conduction and neuronal viability. The degeneration of myelin hinders effective communication and leaves neurons vulnerable to external damage and subsequent degeneration. Abnormalities in oligodendrocyte maturation have been established in the HD human brain, however, investigations into the underlying dysfunction of human oligodendrocytes in HD are limited. This review will detail the involvement of oligodendrocytes and white matter damage in HD. Recent developments in modeling human‐specific oligodendrocyte pathology in HD will be discussed, with a particular focus on emerging somatic cell reprogramming approaches.
Leader Regulatory Goal Setting and Employee Creativity
Authors: Janssen Onne , Vriend Tim , Said Ramzi , Nijstad Bernard 
Published: December 2024

ABSTRACTRecent research suggests that leaders can influence employee creativity by shaping their followers' regulatory focus (promotion or prevention). We propose that this work has overlooked the nature of the regulatory goals (maximal or minimal) that leaders set for their followers. We performed two studies to test this: a vignette‐based experiment with 297 participants and a time‐lagged, multisource field survey involving 335 leader‐employee pairs across various Dutch organizations. Across the two studies, findings reveal that leaders who set maximal goals—emphasizing gains, advancement, and aspirations—significantly enhance their followers' creativity by boosting their promotion focus and intrinsic motivation for creativity. However, leaders who set minimal goals—emphasizing loss avoidance, security, and duty fulfillment—tend to suppress creativity among their followers due to an increased prevention focus and a propensity to conform to the leader's directives. Our novel concept of leader regulatory goal setting demonstrates incremental predictive validity beyond the effects of conventional transformational and transactional leadership styles. Our findings enrich the comprehension of the motivational interplay in leader‐follower exchanges and their creative consequences. Furthermore, this research offers valuable strategies for crafting leadership interventions that effectively stimulate employee creativity.
Tea grading, blending, and matching based on computer vision and deep learning
Authors: Guo Jilong , Zhang Kexin , Adade Selorm Yao‐Say Solomon , Lin Jinsu , Lin Hao , Chen Quansheng 
Published: December 2024

AbstractBACKGROUNDAccurate tea blending assessment and sample matching are critical in the tea production process. Traditional methods face efficiency and accuracy challenges, which can be addressed by advances in computer vision and deep learning. This study developed an efficient and non‐destructive method for fast tea grading classification, blending ratio evaluation, and sample matching. The method trained a Residual Network (ResNet) model on an enhanced dataset of tea images and used Convolutional Block Attention Module (CBAM) to improve the model's feature‐extraction ability.RESULTSThe enhanced grade classification model achieved 95.05% accuracy for oolong tea and 99.13% accuracy for black tea, outperforming other deep‐learning models such as EfficientNet, MobileNet, and VGG16. For oolong tea blends, the model demonstrated greater efficiency than manual evaluation with an average absolute error of 2.26%. In black tea sample matching, the model achieved an average error of 3.34%.CONCLUSIONThese results highlight the importance of attention mechanisms in improving the analysis of images with intricate textures. The integration of deep learning and attention modules enhanced the accuracy and efficiency of tea quality evaluation processes effectively. This study underscores the transformative potential of intelligent classification and analysis methods in modernizing tea production, ensuring higher standards of consistency and quality. © 2024 Society of Chemical Industry.
SIRT5‐mediated HOXA5 desuccinylation inhibits ferroptosis to alleviate sepsis induced‐lung injury
Authors: Wang Lei , Fan Heng , Sun Min , Ye Ji‐Hui 
Published: December 2024

AbstractAcute lung injury (ALI) is a common and severe complication of sepsis with a high mortality rate. Ferroptosis, an iron‐dependent form of cell death, contributes to lung injury. Homeobox A5 (HOXA5) is involved in the regulation of septic acute kidney damage; however, its function on ferroptosis in septic ALI remains unclear. An in vitro model of septic lung injury was established in the pulmonary epithelial cell line (MLE‐12) via lipopolysaccharide (LPS) stimulation. Cell viability, ferrous iron (Fe2+) level, and cellular lipid reactive oxygen species (ROS) were determined with Cell Counting Kit‐8 assay, iron assay kit, and BODIPY™ 665/676 molecular probe, respectively. HOXA5, ferroptosis suppressor protein 1 (FSP1), sirtuin 5 (SIRT5), and glutathione peroxidase 4 (GPX4) expressions were measured using western blotting and Real‐Time Quantitative Polymerase Chain Reaction (RT‐qPCR. Chromatin immunoprecipitation and luciferase reporter assays were performed to validate HOXA5 binding to the FSP1/GPX4 promoter, and regulation of SIRT5 on HOXA5 desuccinylation was confirmed through co‐immunoprecipitation. LPS stimulation induced ferroptosis (reduced cell viability, elevated Fe2+ and lipid ROS levels, and decreased GPX4 levels) and downregulated FSP1 and HOXA5 protein levels. HOXA5 overexpression neutralized LPS‐induced ferroptosis. Moreover, LPS exposure inhibited HOXA5 binding to the FSP1 promoter, which was counteracted via HOXA5 overexpression. Furthermore, SIRT5 overexpression suppressed LPS‐induced ferroptosis. In LPS‐challenged MLE‐12 cells, SIRT5‐mediated HOXA5 desuccinylation was reduced. HOXA5 depletion neutralized the suppressive role of SIRT5 overexpression in LPS‐induced ferroptosis. SIRT5‐mediated HOXA5 desuccinylation inhibited LPS‐induced ferroptosis by upregulating FSP1, which may offer a prospective therapeutic strategy for septic lung injury.
D‐Band MUTC Photodiode Module for Ultra‐Wideband 160 Gbps Photonics‐Assisted Fiber‐THz Integrated Communication System
Authors: Tian Yuxin , Li Yaxuan , Xiong Bing , Zhang Junwen , Sun Changzheng , Hao Zhibiao , Wang Jian , Wang Lai , Han Yanjun , Li Hongtao , Gan Lin , Chi Nan , Luo Yi 
Published: December 2024

AbstractCurrent wireless communication systems are increasingly constrained by insufficient bandwidth and limited power output, impeding the achievement of ultra‐high‐speed data transmission. The terahertz (THz) range offers greater bandwidth, but it also imposes higher requirements on broadband and high‐power devices. In this work, a modified uni‐traveling‐carrier photodiode (MUTC‐PD) module with WR‐6 waveguide output is presented for photonics‐assisted fiber‐THz integrated wireless communications. Through the optimization of the epitaxial structure and high‐impedance coplanar waveguide (CPW), the fabricated 6 µm‐diameter MUTC‐PD achieves a high output power of −0.96 dBm at 150 GHz and ultra‐flat frequency response at D‐band. The MUTC‐PD is subsequently packaged into a compact WR‐6 module, incorporating planar‐circuit‐based RF‐choke, DC‐block, and probe. The packaged PD module demonstrates high saturation power and flat frequency responses with minimal power roll‐off of only ≈2 dB over 110–170 GHz. By incorporating the PD module into a fiber‐THz integrated communication system, the high data rate of up to 160 Gbps with 16 quadrature amplitude modulation (QAM) is successfully secured. The demonstration verifies the potential of the PD module for ultra‐broadband and ultra‐high‐speed THz communications, setting a foundation for future research in high‐speed data transmission.
A Strong Red‐Emitting Phosphor‐in‐BASK‐Glass through Spark Plasma Sintering: Insights into the Role of Interfacial Reaction on PL Efficiencies
Authors: Zhang Manman , Meng Mengmeng , Zhou Lingjun , Wang Panyi , Cui Yingying , Jiang Yangyang , Cai Muzhi , Tang Jintian , Hua Youjie , Calvez Laurent , Qiao Xvsheng , Zhang Xianghua , Xu Shiqing 
Published: December 2024

AbstractRed‐emitting phosphor‐in‐glass (Red‐PiG) color converters are critical for high‐power light‐emitting diode or laser‐driven lighting applications, yet they remain challenging due to the degradation and interfacial reactions of red‐emitting phosphors within glass matrixes. This study investigates the efficacy of spark plasma sintering (SPS) in inhibiting these interfacial reactions across different phosphor and glass compositions. CaAlSiN3:Eu2+ and Sr2Si5N8:Eu2+ phosphors, along with fluoride and borosilicate glasses, are selected to explore their interfacial behavior during SPS. By optimizing the interfacial morphology, a borosilicate‐based PiG with a luminous flux of 248 lm and a luminous efficiency of 173 lm W−1 is achieved, setting new benchmarks for Red‐PiG performance. In addition, laser‐driven white lighting based on the high‐performance Red‐PiG has a color rendering index of up to 90. The findings elucidate the mechanisms by which SPS can enhance interfacial stability and optical performance in Red‐PiG materials, offering strategic insights for advancing the synthesis of high‐quality PiG materials for optoelectronic applications.
Hybrid Thin‐Film Lithium Niobate Micro‐Ring Acousto‐Optic Modulator with Low Half‐Wave‐Voltage‐Length Product
Authors: Wan Lei , Huang Jiying , Wen Meixun , Li Huan , Zhou Wenfeng , Yang Zhiqiang , Chen Yuping , Liu Huilong , Zeng Siqing , Liu Dong , Yang Shuixian , Dai Daoxin , Li Zhaohui 
Published: December 2024

AbstractHighly efficient acousto‐optic modulation plays a vital role in microwave‐to‐optical conversion. Herein, a hybrid thin‐film lithium niobate (TFLN) racetrack micro‐ring acousto‐optic modulator (AOM) implemented with a low‐loss chalcogenide (ChG) waveguide is demonstrated. By engineering the electrode configuration of the interdigital transducer, the double‐arm micro‐ring acousto‐optic modulation is experimentally confirmed in a non‐suspended ChG‐loaded TFLN waveguide platform. Varying the position of the blue‐detuned bias point, the half‐wave‐voltage‐length product V
πL of the hybrid TFLN micro‐ring AOM is as small as 9 mV cm. Accordingly, the acousto‐optic coupling strength is estimated to be 0.48 Hz s1/2 at an acoustic frequency of 0.84 GHz. By analyzing the generation of sideband photon number coupled out of the cavity, the ratio between the microwave photons and first‐order optical sideband photons is calculated to be 2.2 × 10−7% at room temperature. Highly efficient micro‐ring acousto‐optic modulation thus provides new opportunities for expanding TFLN‐ChG hybrid piezo‐optomechanical devices applied in the low‐power‐consumption quantum information transduction.
Salen‐Pd(II)‐Modified Stereoregular Polyisocyanides for Efficient Cooperative Catalysis of Suzuki Coupling Reaction
Authors: Liu Bing‐Hao , Zong Yang , Zhang Han‐Yi , Liu Na , Luo Jing , Wu Zong‐Quan 
Published: December 2024

AbstractThe development of high activity catalysts is crucial for improving industrial efficiency and mitigating environmental pollution. Polyisocyanides, with their pendant groups capable of forming ordered adjacent structures, offer a promising framework for designing cooperative catalysts that mimic the functionality of bimetallic centers. This unique structural arrangement is anticipated to significantly enhance catalytic activity in cooperative reactions. A novel approach to enhance the Suzuki coupling reaction using polymer‐supported catalysts is presented. In this study, stereoregular polyisocyanides with Salen‐Pd are functionalized to produce the Pd(II) metalized polyisocyanide (P1‐Pd). The rigid backbone of the polymer facilitates the parallel alignment of Salen‐Pd pendants, enabling double activation of the two substrates at an average distance of ≈1.2 nm. Catalytic efficiency is evaluated through Suzuki coupling reactions using various aryl halides. P1‐Pd demonstrates high activity, yielding the desired products with excellent conversion rates. Conversely, the irregular polymer counterpart P2‐Pd. P3‐Pd and the small molecule control C1‐Pd exhibit lower performance due to the absence of cooperative catalysis. To showcase the applicability of this strategy, Suzuki coupling is successfully conducted with outstanding yields for key drug intermediates, while also offering innovative insights for conjugated polymer synthesis.
Prediction of dynamic recrystallization behavior of SAE52100 large section bearing steel based on machine learning
Authors: Ding Peiheng , Shu Changqing , Zhang Shasha , Zhang Zhaokuan , Liu Xingshuai , Zhang Jicong , Chen Qian , Yu Shuaipeng , Zhu Xiaolin , Yao Zhengjun 
Published: December 2024

AbstractThis paper investigates the dynamic recrystallization characteristics of SAE52100 large section bearing steel under hot compression, focusing on both the center and surface. Using data from thermal simulation experiments the physical models were developed. Four machine learning algorithms including support vector regression, k‐nearest neighbors, random forest, and extreme gradient boosting were then employed to develop dynamic recrystallization prediction models based on the experimental data and inferred values from the physical model. The results show that the machine learning methods provide a better numerical description of the model, provided these are fed with extensive data. To enhance the scope of application, we obtained data from the dynamic recrystallization models for both the center and surface of SAE52100 steel in the as‐cast state, as well as extrapolated values from the literature regarding the hot‐rolled condition. When the SHAP method was introduced to reveal the mechanism of the influence of each input feature on the prediction results of the machine learning model, it was found that the test results of the Cr element did not match the theory, mainly because of the small scale of Cr elemental data and the strong dependence on grain size and secondary dendrite spacing.