bluuebunny/crossref_metadata_2025_split huggingface dataset:
The combination treatment of cholesterol‐loaded methyl‐β‐cyclodextrin and methyl‐β‐cyclodextrin significantly improves the fertilization capacity of vitrified bovine oocytes by protecting fertilization protein JUNO
Authors: Hao Tong , Zhang Peipei , Hao Haisheng , Du Weihua , Pang Yunwei , Zhao Shanjiang , Zou Huiying , Zhu Huabin , Yu Weili , Li Shujing , Zhao Xueming 
Published: January 2021

AbstractMany experiments show that vitrification significantly reduces the fertilization capacity of mammalian oocytes, restricting the application of vitrified oocytes. It has been proven that the JUNO protein plays a vital role in mammalian oocytes fertilization. However, little information is available about the effects of vitrification on the JUNO protein and the procedure to protect it in bovine oocytes. Here, the present study was designed to investigate the effect of vitrification on the JUNO protein level in bovine oocytes. In this study, MII oocytes were treated with cholesterol‐loaded methyl‐β‐cyclodextrin (CLC; 0, 10, 15, 20 mM) for 45 min before vitrification and methyl‐β‐cyclodextrin (MβCD; 0, 2.25, 4.25, 6.25 mM) for 45 min after thawing (38–39°C). Then, the expression level and function of JUNO protein, cholesterol level in the membrane, the externalization of phosphatidylserine, sperm binding capacity and the developmental ability of vitrified bovine oocytes were examined. Our results showed that vitrification significantly decreased the JUNO protein level, cholesterol level, sperm binding capacity, development ability, and increased the promoter methylation level of the JUNO gene and apoptosis level of bovine oocytes. Furthermore, 15 mM CLC + 4.25 mM MβCD treatment significantly improved the cholesterol level and increased sperm binding and development ability of vitrified bovine oocytes. In conclusion, the combination treatment of cholesterol‐loaded methyl‐β‐cyclodextrin and methyl‐β‐cyclodextrin significantly improves the fertilization capacity of vitrified bovine oocytes by protecting fertilization protein JUNO.
Accuracy of molecular drug susceptibility testing amongst tuberculosis patients in Karakalpakstan, Uzbekistan
Authors: Gil Horacio , Margaryan Hasmik , Azamat Ismailov , Ziba Bekturdieva , Bayram Halmuratov , Nazirov Pirimqul , Gomez Diana , Singh Jatinder , Zayniddin Sayfutdinov , Parpieva Nargiza , Achar Jay 
Published: January 2021

AbstractObjectivesIn this retrospective study, we evaluated the diagnostic accuracy of molecular tests (MT) for the detection of DR‐TB, compared to the gold standard liquid‐based drug susceptibility testing (DST) in Karakalpakstan.MethodsA total of 6670 specimens received in the Republican TB No 1 Hospital Laboratory of Karakalpakstan between January and July 2017 from new and retreatment patients were analysed. Samples were tested using Xpert MTB/RIF and line probe assays (LPA) for the detection of mutations associated with resistance. The sensitivity and specificity of MTs were calculated relative to results based on DST.ResultsThe accuracy of MT for detection of rifampicin resistance was high, with sensitivity and specificity over 98%. However, we observed reduced sensitivity of LPA for detection of resistance; 86% for isoniazid (95% CI 82–90%), 86% for fluoroquinolones (95% CI 68‐96%), 70% for capreomycin (95% CI 46–88%) and 23% for kanamycin (95% CI 13–35%).ConclusionsWe show that MTs are a useful tool for rapid and safe diagnosis of DR‐TB; however, clinicians should be aware of their limitations. Although detection of rifampicin resistance was highly accurate, our data suggest that resistance mutations circulating in the Republic of Karakalpakstan for other drugs were not detected by the methods used here. This merits further investigation.
β‐cell dysfunction and insulin resistance in relation to pre‐diabetes and diabetes among adults in north‐western Tanzania: a cross‐sectional study
Authors: PrayGod George , Filteau Suzanne , Range Nyagosya , Kitilya Brenda , Kavishe Bazil B. , Ramaiya Kaushik , Jeremiah Kidola , Rehman Andrea M. , Changalucha John , Olsen Mette Frahm , Andersen Aase Bengaard , Friis Henrik , Krogh‐Madsen Rikke , Faurholt‐Jepsen Daniel 
Published: January 2021

AbstractObjectiveStudies on phenotypes of diabetes in Africa are inconsistent. We assessed the role of β‐cell dysfunction and insulin resistance on pre‐diabetes and diabetes.MethodsWe included 1890 participants with mean age of 40.6 (SD11.9) years in a cross‐sectional study among male and female adults in Tanzania during 2016 to 2017. Data on C‐reactive protein (CRP), alpha‐acid glycoprotein (AGP), HIV, oral glucose tolerance test (OGTT), body composition and insulin were collected. Insulinogenic index and HOMA‐IR were used to derive an overall marker of β‐cell dysfunction and insulin resistance which was categorised as follows: normal β‐cell function and insulin sensitivity, isolated β‐cell dysfunction, isolated insulin resistance, and combined β‐cell dysfunction and insulin resistance. Pre‐diabetes and diabetes were defined as 2‐hour OGTT glucose between 7.8–11.0 and ≥ 11.1 mmol/L, respectively. Multinomial regression assessed the association of β‐cell dysfunction and insulin resistance with outcome measures.Resultsβ‐cell dysfunction, insulin resistance, and combined β‐cell dysfunction and insulin resistance were associated with higher pre‐diabetes risk. Similarly, isolated β‐cell dysfunction (adjusted relative risk ratio (aRRR) 4.8 (95% confidence interval (CI) 2.5, 9.0), isolated insulin resistance (aRRR 3.2 (95% CI 1.5, 6.9), and combined β‐cell dysfunction and insulin resistance (aRRR 35.9 (95% CI 17.2, 75.2) were associated with higher diabetes risk. CRP, AGP and HIV were associated with higher diabetes risk, but fat mass was not. 31%, 10% and 33% of diabetes cases were attributed to β‐cell dysfunction, insulin resistance, and combined β‐cell dysfunction and insulin resistance, respectively.Conclusionsβ‐cell dysfunction seemed to explain most of diabetes cases compared to insulin resistance in this population. Cohort studies on evolution of diabetes in Africa are needed to confirm these results.
Validation of the Physical Activity Questions in the World Health Organization Health Behavior in School-Aged Children Survey Using Accelerometer Data in Japanese Children and Adolescents
Authors: Tanaka Chiaki , Kyan Akira , Takakura Minoru , Olds Tim , Schranz Natasha , Tanaka Shigeho 
Published: January 2021

Background: An international physical activity (PA) questionnaire is beneficial to make cross-country comparisons among children and adolescents. This study assesses the validity of the PA questions in the World Health Organization Health Behavior in School-Aged Children (WHO HBSC) survey in Japanese children and adolescents. Methods: Participants were fifth- to sixth-grade Japanese primary school students (67 students aged 10.8 [0.5] y) and first- to third-grade junior high school students (108 students aged 13.0 [0.7] y). The Japanese version of the PA questions in the WHO HBSC (WHO HBSC-J) was used. To assess the validity of the PA questions, the authors used a partial correlation adjusted for sex, age, and relative weight between the answers to the survey questions and objectively measured moderate to vigorous PA (MVPA) by an accelerometer. Results: A significant positive correlation was found between accelerometer-measured MVPA and the number of reported days with at least 60 minutes/day of MVPA in primary school students (r = .39, P = .002) and junior high school students (r = .32, P < .001). Conclusion: The HBSC-J has moderate validity for evaluating MVPA in Japanese primary school and junior high school students.
The National Academy of Kinesiology 2020 Review and Evaluation of Doctoral Programs in Kinesiology
Authors: Challis John H. 
Published: January 2021

The results of the 2020 review and ranking of U.S. doctoral programs in kinesiology conducted by the National Academy of Kinesiology (NAK) are presented. These results represent data collected for the 2015, 2016, 2017, 2018, and 2019 calendar years for 43 programs. The rankings reflect data collected on program faculty (productivity, funding, and visibility) and program students (admissions, support, publications, and employment). The data for each assessment index were first transformed intozscores, and then thezscores converted intoT-scores. Weights were applied to theT-scores of the indices and then summed to obtain a totalT-score. Programs were ranked in two ways: one based on the totalT-scores from the data not normalized (unadjusted) and the other with totalT-scores from the data normalized with respect to the number of faculty members in each program (adjusted). In addition to program rankings, descriptive data are presented on faculty and student data.
Clinicoserological features of antisynthetase syndrome (ASyS)-associated interstitial lung disease presenting to respiratory services: comparison with idiopathic pulmonary fibrosis and ASyS diagnosed in rheumatology services
Authors: Barratt Shaney L , Adamali Havra H , Cotton Caroline , Mulhearn Ben , Iftikhar Hina , Pauling John David , Spencer Lisa , Adamali Huzaifa I , Gunawardena Harsha 
Published: January 2021

IntroductionAntisynthetase syndrome (ASyS) is a rare autoimmune connective tissue disease (CTD), associated with autoantibodies targeting tRNA synthetase enzymes, that can present to respiratory (interstitial lung disease (ILD)) or rheumatology (myositis, inflammatory arthritis and systemic features) services. The therapeutic management of CTD-associated ILD and idiopathic pulmonary fibrosis (IPF) differs widely, thus accurate diagnosis is essential.MethodsWe undertook a retrospective, multicentre observational cohort study designed to (1) evaluate differences between ASyS-associated ILD with IPF, (2) phenotypic differences in patients with ASyS-ILD presenting to respiratory versus rheumatology services, (3) differences in outcomes between ASySassociated with Jo-1 versus non-Jo-1 autoantibodies and (4) compare long-term outcomes between these groups.ResultsWe identified 76 patients with ASyS-ILD and 78 with IPF. Patients with ASyS were younger at presentation (57 vs 77 years, p<0.001) with a female predominance (57% vs 33%, p=0.006) compared with IPF. Cytoplasmic staining on indirect immunofluorescence was a differentiating factor between ASyS and IPF (71% vs 0%, p<0.0001). Patients with ASyS presenting initially to respiratory services (n=52) had a higher prevalence of ASyS non-Jo-1 antibodies and significantly fewer musculoskeletal symptoms/biochemical evidence of myositis, compared with those presenting to rheumatology services (p<0.05), although lung physiology was similar in both groups. There were no differences in high-resolution CT appearances or outcomes in those with Jo-1 versus non-Jo-1 ASyS-ILD.ConclusionsExtended autoimmune serology is needed to evaluate for ASyS autoantibodies in patients presenting with ILD, particularly in younger female patients. Musculoskeletal involvement is common in ASyS (typically Jo-1 autoantibodies) presenting to rheumatology but the burden of ILD is similar to those presenting to respiratory medicine.
Danger zone assessment in small-sided recreational football: providing data for consideration in relation to COVID-19 transmission
Authors: Randers Morten B , Knudsen Nikolas Sten , Thomasen Manuel Mounir Demetry , Panduro Jeppe , Larsen Malte Nejst , Mohr Magni , Milanovic Zoran , Krustrup Peter , Andersen Thomas Bull 
Published: January 2021

During the COVID-19 pandemic, physical inactivity has increased, and a wide range of sporting activities locked down, with possible long-term implications for public health. Football is the most popular sport worldwide, and recreational football training leads to broad-spectrum health effects. Football is, however, deemed a contact sport with frequent close contact important to consider during COVID-19 pandemic.ObjectivesThis study investigated time spent with close contact (danger zone (DZ) within 1.5 m), number of contacts and time per contact, and compared game formats in recreational small-sided football games for young and adult male football players.MethodsMovement analyses were performed on 10 Hz Global Positioning System (GPS) data collected during various small-sided football games prior to the COVID-19 outbreak.ResultsTime spent in the DZ was 4.3–7.9 s/h per per cent infected players, corresponding to 34.3–114.8 s/h if one player was infected. Number of contacts with one infected player was 23.5–87.7 per hour, with an average contact time of 1.1–1.4 s, and a total number of contacts of 311–691 per hour with all players. 53%–65% of all contacts were shorter than 1 s and 77%–85% shorter than 2 s. Trivial to small effects were found for number of participants and area per player, whereas standard of play and playing with/without boards had no effect.ConclusionThis study demonstrated that during small-sided football limited time is spent within DZ and that player contacts are brief. Recreational football may therefore more appropriately be deemed as sporting activity with brief, sporadic contact.
Sex differences in patients undergoing transcatheter aortic valve replacement in Asia
Authors: Chiam Paul T L , Hayashida Kentaro , Watanabe Yusuke , Yin Wei-Hsian , Kao Hsien-Li , Lee Michael K Y , Posas Fabio Enrique , Chandavimol Mann , Buddhari Wacin , Dy Timothy C , Nguyen Ngoc Quang , Kim Won Jang , Chang Kiyuk , Lin Mao-Shin , Lam Yat-Yin , Pham Hung Manh , Yahaya Shaiful Azmi , Ho Kay Woon , Pan Wenzhi , Liu Xian-bao , Wang Jian'an , Kim Hyo Soo , Chen Mao 
Published: January 2021

ObjectivesTranscatheter aortic valve replacement (TAVR) is increasingly performed. Physically small Asians have smaller aortic root and peripheral vessel anatomy. The influence of gender of Asian patients undergoing TAVR is unknown and may affect outcomes. The aim of this study was to assess sex differences in Asian patients undergoing TAVR.MethodsPatients undergoing TAVR from eight countries were enrolled. In this retrospective analysis, we examined differences in characteristics, 30-day clinical outcomes and 1-year survival between female and male Asian patients.ResultsEight hundred and seventy-three patients (54.4% women) were included. Women were older, smaller and had less coronary artery and lung disease but tended to have higher logistic EuroSCOREs. Smaller prostheses were used more often in women. Major vascular complications occurred more frequently in women (5.5% vs 1.8%, p<0.01); however, 30-day stroke and mortality (women vs men: 1.5% vs 1.6%, p=0.95% and 4.3% vs 3.4%, p=0.48) were similar. Functional status improvement was significant and comparable between the sexes. Conduction disturbance and permanent pacemaker requirements (11.2% vs 9.0%, p=0.52) were also similar as was 1-year survival (women vs men: 85.6% vs 88.2%, p=0.25). The only predictors of 30-day mortality were major vascular injury in women and age in men.ConclusionsAsian women had significantly smaller stature and anatomy with some differences in clinical profiles. Despite more frequent major vascular complications, women had similar 30-day stroke or mortality rates. Functional status improvement was significant and comparable between the sexes. Conduction disturbance and permanent pacemaker requirements were similar as was 1-year survival.
Implementation of the ATLAS-SUSY-2018-04 analysis in the MadAnalysis 5 framework (staus in the di-tau plus missing transverse energy channel; 139 fb−1)
Authors: Lim Jongwon , Lu Chih-Ting , Park Jae-Hyeon , Park Jiwon 
Published: January 2021

We present the MadAnalysis 5 implementation and validation of the ATLAS-SUSY-2018-04 search. This ATLAS analysis targets direct stau production in events with two hadronic tau leptons, and probes 139 fb[Formula: see text] of LHC proton–proton collisions at a center-of-mass energy of 13 TeV. The validation of our re-implementation relies on a comparison of our cutflow predictions with the auxiliary material and official results provided by the ATLAS collaboration in the context of two supersymmetry-inspired simplified benchmark models in which the Standard Model is extended by a neutralino and a stau decaying into a tau lepton and a neutralino. A first scenario focuses on very light staus, whereas a second one addresses heavier staus. Our predictions have been found to agree with ATLAS official cutflows at the level of 6–8% in the heavy stau scenario, and exhibit a larger discrepancy (of 15–50%) in the light stau scenario. This disagreement is however considered as not too significant, as both ATLAS and MadAnalysis 5 predictions come with large Monte Carlo numerical uncertainties.
Some specific wormhole solutions in f(R)-modified gravity theory
Authors: Ghosh Bikram , Mitra Saugata , Chakraborty Subenoy 
Published: January 2021

The paper deals with the static spherically symmetric wormhole solutions in [Formula: see text]-modified gravity theory with anisotropic matter field and for some particular choices for the shape functions. This work may be considered as an extension of the general formalism in [S. Halder, S. Bhattacharya and S. Chakraborty, Phys. Lett. B 791, 270 (2019)] for finding wormhole solutions. For isotropic matter distribution it has been shown that wormhole solutions are possible for zero tidal force and it modifies the claim in [M. Cataldo, L. Leimpi and P. Rodriguez, Phys. Lett. B 757, 130 (2016)]. Finally, energy conditions are examined and it is found that all energy conditions are satisfied in a particular domain with a particular choice of the shape function.
Quantum teleportation of an arbitrary four-qubit state via three-uniform state of eight qubits
Authors: Cao Zhanli , Zhang Yunguang , Qi JianXia 
Published: January 2021

Recently, Zang et al. constructed a three-uniform state of eight qubits. In this work, we show that such an eight-qubit entangled state can be used to realize the deterministic quantum teleportation of an arbitrary four-qubit state based on the orthogonal basis measurement.
Knowledge base of Cenozoic volcanoes in China
Authors: Pan Bo , Cheng Tao , Xu Jiandong , Zhang Jingwei , Chen Zhengquan 
Published: January 2021

Abstract
Knowledge management plays an important role in scientific research and provides a basis for technical development in the era of Big Data. Studies of Cenozoic volcanoes in China have been undertaken for more than half a century, generating plentiful relevant literature and data. However, these data have stayed scattered between different authors and libraries, and this hampers management and access. Based on theories, knowledge bases and related technologies, we developed the Knowledge Base of Cenozoic Volcanoes (KBCV) to collect such volcanic data in China. The directory tree of the KBCV is structured based on five levels according to the volcano distribution, magma origin, data type and file format. The KBCV supports querying, searching and browsing. It can provide well-managed Cenozoic volcanic data and technical support for scientific research and public communication. The KBCV is still in its early stages and is imperfect with respect to data completeness and universalization of the system, and efforts are being made to continuously develop and popularize the system.
Strategies for Success: Landing Your First Academic Position and Navigating the Early Years—A Report from the American Society of Preventive Oncology's Early Career Investigator Special Interest Group
Authors: Khan Saira , Hardikar Sheetal , Reeves Katherine W. , Wetter David W. , Burton-Chase Allison M. 
Published: January 2021

Abstract
As part of the 2019 American Society of Preventative Oncology (ASPO) annual meeting, the Early Career Investigator Special Interest Group organized a session entitled “Strategies for Success: Landing Your First Academic Position and Navigating the Early Years.”* This session was designed to provide senior doctoral students and postdoctoral fellows with strategies for preparing successful faculty job applications. Furthermore, strategies and best practices to help guide early career faculty through the initial years of their academic positions were also discussed. This report summarizes the main themes of the session, including advice and recommendations from the panelists.
Safety and Feasibility of Same-Day Discharge After Left Atrial Appendage Closure With the WATCHMAN Device
Authors: Tan Bryan E-Xin , Boppana Leela Krishna Teja , Abdullah Abdullah S. , Chuprun Dmitry , Shah Abrar , Rao Mohan , Bhatt Deepak L. , Depta Jeremiah P. 
Published: January 2021

Background:
As the use of left atrial appendage closure (LAAC) becomes more widespread, improvements in resource utilization and cost-effectiveness are necessary. Currently, there are limited data on same-day discharge (SDD) after LAAC. We aimed to evaluate the safety and feasibility of SDD versus non-SDD in patients with nonvalvular atrial fibrillation who underwent LAAC.

Methods:
We retrospectively studied 211 patients who underwent the WATCHMAN procedure in a tertiary hospital (June 2016 to June 2019). The primary safety outcome was the composite of stroke, systemic embolism, major bleeding requiring transfusion, vascular complications requiring endovascular intervention, or death through 7 days (periprocedural) and 45 days post-procedure. The secondary outcomes were the individual components of the primary outcome and all-cause readmission. We compared the clinical outcomes of patients who had SDD and non-SDD post-procedure.

Results:

Patients with procedure-related complications on the day of LAAC and patients who were admitted for acute clinical events before LAAC were excluded. One hundred ninety patients were included in the final analysis. Seventy-two of 190 (38%) patients had SDD, and 118 of 190 (62%) had non-SDD. There were no statistically significant differences in the primary safety outcome through 7 days (1.4% versus 5.9%;
P
=0.26) and 45 days post-procedure (2.8% versus 9.3%;
P
=0.14) between the two groups. The secondary outcomes were similar in both groups. No patients had device-related thrombus on transesophageal echocardiography at 45 days. Only 1 patient from the non-SDD group had clinically significant peri-device flow (>5 mm) at 45 days.

Conclusions:
In a selected cohort of patients who underwent successful elective LAAC with WATCHMAN without same-day procedure-related complications, the primary safety outcome and secondary outcomes through 7 and 45 days post-procedure were similar in the SDD and non-SDD groups. Our findings are hypothesis generating and warrant further investigation in prospective trials.