bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longer Neurophysiological vs. Clinical Recovery Following Sport Concussion
Authors: Ntikas Michail , Hunter Angus M. , Gallagher Iain J. , Di Virgilio Thomas G. 
Published: December 2021

Objectives:The objective of this study was to assess if injury-related alterations in the Sport Concussion Assessment Tool-5 (SCAT5) are matched by changes in transcranial magnetic stimulation-derived intracortical inhibition. We hypothesised that neurophysiological measures would take longer to return to normal than recovery assessed by the SCAT5 following sport related concussion (SRC).Methods:Thirteen male contact sport athletes (20.5 ± 4.5 years), who reported a concussion were recruited from local Rugby and American football clubs. Participants were tested at 4 timepoints throughout the concussion recovery period: within 24 h of concussion (day 0), and at 7, 9, and 11 days after concussion. All participants completed the SCAT5 and underwent TMS to assess cortical silent period duration (CSp), a measure of intracortical inhibition.Results:After concussion CSp significantly declined from day 0 (122 ± 28 ms) to day 11 (106 ± 15 ms) [F(3, 33)= 7.80,p&lt; 0.001]. SCAT5 measures of symptom number and severity were significantly decreased [symptom number:χ(3)2= 30.44,p&lt; 0.01; symptom severity:χ(3)2= 25.75,p&lt; 0.001] between the day 0 timepoint and each of the other timepoints. SCAT5 balance errors (mBESS) decreased significantly [F(3, 33)= 19.55,p&lt; 0.001] between the day 0 timepoint and each of the other timepoints. CSp and SCAT5 recovery patterns were different. SCAT5 domains recovered faster showing no further significant changes after day 7, whilst CSp was still decreasing between days 7 and 9. Due to the small sample size we also used a Bayesian linear model to investigate the recovery of CSp and mBESS. The posterior distribution of our Bayesian model provided evidence that CSp decreased at day 7 and it continued to decrease at day 9, unlike mBESS which decreased at day 7 and then reached a plateau.Conclusion:There are clinically important discrepancies between clinical and neurophysiological measures of concussion recovery. This finding has important implications for return to play (RTP) protocols and the prevention of complications after sport concussion.
Using Patient-Derived Xenografts to Explore the Efficacy of Treating Head-and-Neck Squamous Cell Carcinoma With Anlotinib
Authors: Hu Fangling , Guo Liang , Yu Jieqing , Dai Daofeng , Xiong Yuanping , He Yuanqiao , Zhou Wensheng 
Published: December 2021

Objective: The efficacy of anlotinib as a treatment for head-and-neck squamous cell carcinoma (HNSCC) has been little explored. Here, we used patient-derived xenografts (PDXs) to this end.Methods: Fresh tumor tissues of HNSCC patients were screened in terms of in vitro drug sensitivity using the MTT assay. Patient PDXs were used to confirm the anti-tumor effects of anlotinib in vivo. After the medication regimen was complete, the tumor volume changes in mice were calculated. Apoptosis was measured using the TUNEL assay. The cell proliferation and apoptosis levels of PDXs yielded data on the utility of anlotinib treatment in vivo.Results: Anlotinib suppressed the in vitro proliferation of nine tumor tissues by an average of 51.05 ± 13.74%. Anlotinib also significantly inhibited the growth of three PDXs in mice (tumor growth inhibition 79.02%). The expression levels of Ki-67 and proliferating cell nuclear antigen after anlotinib treatment were significantly lower than those in the controls. The negative and positive controls exhibited no and some apoptosis, respectively, whereas the anlotinib group evidenced extensive apoptosis.Conclusion: Anlotinib suppressed HNSCC growth in vitro and in vivo (by inhibiting cell proliferation and promoting apoptosis), suggesting that anlotinib can potentially treat HNSCC.
Sistema de gestión ambiental a nivel empresarial
Authors: Escalona Fernández Yordanis , Tamayo Ronda Yusimi 
Published: December 2021

Environmental management system at corporate level
Resumen
La investigación se desarrolló de enero 2012 a julio del 2015, posibilitó la elaboración participativa de un sistema de gestión ambiental a partir de la evaluación del desempeño básico y ambiental de la Planta de Biopreparados Sucursal Laboratorios Biofarmacéuticos (LABIOFAM) Las Tunas, hasta la propuesta de acciones a implementar así como el sistema de indicadores ambientales para su seguimiento y control. Los resultados del diagnóstico de la entidad revelan la existencia de insuficiencias que limitan su evaluación y transformación en la proyección empresarial. La valoración del diseño del sistema de gestión ambiental evidencia su factibilidad, como alternativa a la necesidad de herramientas que contribuyan a la participación, evaluación, proyección y a la toma de decisiones de los actores decisores en la gestión de este proceso a nivel empresarial.
Palabras clave: biopreparados; evaluación; indicadores; participativo; proyección.
Abstract
The research was carried out from January 2012 to July 2015, made possible the participatory elaboration of an environmental management system based on the evaluation of the basic and environmental performance of the Biopharmaceutical Laboratory Biopharmaceutical Plant (LABIOFAM) Las Tunas, up to the proposal of actions to be implemented as well as the system of environmental indicators for monitoring and control. The results of the entity's diagnosis reveal the existence of shortcomings that limit its evaluation and transformation in business projection. The evaluation of the design of the environmental management system shows its feasibility, as an alternative to the need for tools that contribute to the participation, evaluation, projection and decision making of the decision makers in the management of this process at the enterprise level.
Keywords: bioprepared; evaluation; indicators, participatory, projection.
Evaluación de parámetros físico-químicos y organolépticos de una leche fermentada enriquecida con quinua (Chenopodium quinoa)
Authors: Bravo Mera Jandry Antonio , Vera Verduga Gema Carolina , Andrade Andrade Virginia Vanessa , Gorozabel Muñoz Wagner Antonio , García Mendoza Jordán Javier 
Published: December 2021

Evaluation of physico-chemical and organoleptic parameters of a fermented milk enriched with quinoa (Chenopodium quinoa)
Resumen
La harina de quinua presenta diversos aportes nutricionales requeridos en la alimentación, lo cual hace de este producto una alternativa viable para ser involucrado en diferentes procesos de interés agroindustrial. El objetivo del presente estudio fue evaluar los parámetros físico-químicos y organolépticos de una leche fermentada (yogurt) enriquecida con harina de quinua. Se utilizó un diseño experimental completamente al azar con un nivel de significancia de p<0,05 utilizando la prueba de Duncan. El factor en estudio fue la adición de harina de quinua en niveles del 1%(T1), 3%(T2) y 5%(T3) más un tratamiento testigo T0 (0% quinua). Las variables evaluadas fueron (proteína, grasa, pH y acidez) además mediante un panel sensorial se analizaron los atributos sensoriales (sabor, olor, color, textura y apariencia general). Los resultados indicaron que el T2 con 3% harina de quinua fue el de mayor aceptación, los cuales presentaron valores de proteína de 5,1%; grasa 3,2%, pH 4,89 y la acidez fue no significativo entre los tratamiento teniendo un C.V. de 3,88. El análisis sensorial presentó diferencia significativa al 5% en todos los tratamientos. Se logró determinar que la harina de quinua influyó sobre las características físico-químicas ya que todas las formulaciones estuvieron dentro de los límites permisibles por la INEN 2395:2011.
Palabras clave: Leche fermentada; quinua; análisis organoléptico; proteína; grasa.
Abstract
Quinoa flour has various nutritional contributions required in food, which makes this product a viable alternative to be involved in different processes of agroindustrial interest. The objective of this study was to evaluate the physicochemical and organoleptic parameters of fermented milk (yogurt) enriched with quinoa flour. A completely randomized experimental design with a significance level of p <0.05 was used using the Duncan test. The factor under study was the addition of quinoa flour at levels of 1% (T1), 3% (T2) and 5% (T3) plus a T0 control treatment (0% quinoa). The variables evaluated were (protein, fat, pH and acidity), in addition, a sensory panel analyzed the sensory attributes (taste, smell, color, texture and general appearance). The results indicated that T2 with 3% quinoa flour was the most widely accepted, which presented protein values ​​of 5.1%; 3.2% fat, pH 4.89 and acidity was not significant among the treatments having a C.V. of 3.88. The sensory analysis showed a significant difference at 5% in all treatments. It was possible to determine that quinoa flour influenced the physicochemical characteristics since all the formulations were within the limits allowed by INEN 2395: 2011.
Keywords: Fermented milk; quinoa organoleptic analysis; protein; grease.
Evaluación del impacto de la cacería de la Cuniculus paca en Flavio Alfaro, Manabí, Ecuador
Authors: Rodríguez Ríos Elvira Bernardita , García Páez Benjamín , Cartaya Ríos Scarlet , Gracia Panta Edison 
Published: December 2021

Impact of the hunting of the Cuniculus paca in Flavio Alfaro, Manabí, Ecuador
Resumen
Cuniculus paca (guanta) es una especie silvestre muy utilizada que, además de su valor cinegético cumple un rol fundamental en los ecosistemas, por su posición clave en la cadena trófica. El objetivo de este artículo es evaluar la sostenibilidad de la caza Cuniculus paca en Flavio Alfaro, Manabí, Ecuador. En esa perspectiva, se utiliza un modelo de cosecha que integra variables de cacería y de vulnerabilidad que incorporan la productividad biológica y tasas de cacería para predecir la sostenibilidad de la caza mediante el análisis de la relación entre la producción y la cosecha. Los resultados obtenidos muestran que la cacería de la guanta en los términos que se ejecuta constituye una actividad insostenible en el largo plazo. Asimismo, los hallazgos empíricos encontrados indican la necesidad de hacer política pública relativa tanto a la guanta como a otras especies cercanas a ella en la provisión de carne de monte en la localidad, con una visión en que su aprovechamiento se restrinja mediante los valores de extracción determinados en el presente estudio a fin de equilibrar bienestar social de los cazadores que viven en condiciones de subsistencia y el aseguramiento de la reproducción sostenible de la especie en el largo plazo.
Palabras clave: Carne de monte; Cuniculus paca; especie cinegética; comunidades rurales.
Abstract
Cuniculus paca (guanta) is a widely consumption wild species that, in addition to its hunting value, plays a fundamental role in the ecosystems, due to its key position in the trophic chain. This article is aimed at valuing hunting sustainability of the Cuniculus paca in Flavio Alfaro, Manabí, Ecuador. In such endeavor a theoretical model of harvesting which include biological productivity and hunting rates variables, it is used. The results obtained show that hunting of the guanta in the way is running in the present time, it categorically is an unsustainable activity in the long term. Likewise, such empirical findings are clear enough of the urgent need of the making of public policy not only for threatened species like the guanta, but also for other species close to her in the supply of bushmeat in the study area. Due to the hunting and consuming bushmeat has been a cultural norm and survival strategy for the rural people, the authors' proposal is not put guanta’s consumption away from family consumption, but to create a new legal framework to sensitive them to restrict seasonal hunting periods to a set of quantitative standards estimated in this paper. Therefore, considerable effort must to be made to protect bushmeat sources to avoid its depletion in the long term.
Keywords: Bushmeat; Cuniculus paca; Ecuador; game species; rural communities.
Pharmacogenomics of Hypertension in CKD: The CKD-PGX Study
Authors: Eadon Michael T. , Maddatu Judith , Moe Sharon M. , Sinha Arjun D. , Melo Ferreira Ricardo , Miller Brent W. , Sher S. Jawad , Su Jing , Pratt Victoria M. , Chapman Arlene B. , Skaar Todd C. , Moorthi Ranjani N. 
Published: December 2021

Key Points

The CKD-PGX study assessed the feasibility of pharmacogenomic testing for a panel of antihypertensive agent efficacy predictors.Most patients with uncontrolled hypertension had one or more drug-gene interactions predicting reduced efficacy of their medications.In 36% of cases, practitioners used genetic data to change BP management in their patients with CKD.

Background
Patients with CKD often have uncontrolled hypertension despite polypharmacy. Pharmacogenomic drug-gene interactions (DGIs) may affect the metabolism or efficacy of antihypertensive agents. We report changes in hypertension control after providing a panel of 11 pharmacogenomic predictors of antihypertensive response.

Methods
A prospective cohort with CKD and hypertension was followed to assess feasibility of pharmacogenomic testing implementation, self-reported provider utilization, and BP control. The analysis population included 382 subjects with hypertension who were genotyped for cross-sectional assessment of DGIs, and 335 subjects followed for 1 year to assess systolic BP (SBP) and diastolic BP (DBP).

Results
Most participants (58%) with uncontrolled hypertension had a DGI reducing the efficacy of one or more antihypertensive agents. Subjects with a DGI had 1.85-fold (95% CI, 1.2- to 2.8-fold) higher odds of uncontrolled hypertension, as compared with those without a DGI, adjusted for race, health system (safety-net hospital versus other locations), and advanced CKD (eGFR <30 ml/min). CYP2C9-reduced metabolism genotypes were associated with losartan response and uncontrolled hypertension (odds ratio [OR], 5.2; 95% CI, 1.9 to 14.7). CYP2D6-intermediate or -poor metabolizers had less frequent uncontrolled hypertension compared with normal metabolizers taking metoprolol or carvedilol (OR, 0.55; 95% CI, 0.3 to 0.95). In 335 subjects completing 1-year follow-up, SBP (−4.0 mm Hg; 95% CI, 1.6 to 6.5 mm Hg) and DBP (−3.3 mm Hg; 95% CI, 2.0 to 4.6 mm Hg) were improved. No significant difference in SBP or DBP change were found between individuals with and without a DGI.

Conclusions
There is a potential role for the addition of pharmacogenomic testing to optimize antihypertensive regimens in patients with CKD.
Towards a Common Standard Framework for Blockchain Interoperability - A Position Paper
Authors: Belchior Rafael , Scuri Sabrina , Mihaiu Iulia , Nunes Nuno , Hardjono Thomas 
Published: December 2021

<p>Decentralized ledger technology (DLT) is becoming ubiquitous in today's society. After an initial grassroots adoption, enterprises embrace this technology, following the opportunity to expand to new businesses - the technology is maturing. However, organizations need to connect their existing systems and processes to blockchains (centralized - decentralized) securely and reliably, sometimes also implying to connect blockchains (decentralized - decentralized). This challenge is known as blockchain interoperability.</p>
<p>Blockchain interoperability comes in three modes: data transfers, asset transfers, and asset exchanges. As blockchain interoperability is still maturing, there are many unsolved challenges across the different interoperability modes. In this \emph{position paper}, we illustrate the remaining challenges of interoperability, focusing on the systematic evaluation of interoperability mechanisms, based on the state of the art and our own experience. We first introduce the notion of cross-chain interoperability and cross-chain rules. Then, we present our survey and results. </p>
<p>We ran an online survey comprised of 17 items targeting blockchain specialists. Our quantitative analysis shows that several interesting metrics can show promising directions to evaluate integration solutions systematically. Finally, building upon our study, we propose the blockchain interoperability evaluation framework, the first step to evaluate blockchain interoperability solutions systematically.</p>
Computation of Wavelet and Multiwavelet Transforms Using Fast Fourier Transform
Authors: Mahmoud Walid Amin 
Published: December 2021

A novel fast and efficient algorithm was proposed that uses the Fast Fourier Transform (FFT) as a tool to compute the Discrete Wavelet Transform (DWT) and Discrete Multiwavelet Transform. The Haar Wavelet Transform and the GHM system are shown to be a special case of the proposed algorithm, where the discrete linear convolution will adapt to achieve the desired approximation and detail coefficients. Assuming that no intermediate coefficients are canceled and no approximations are made, the algorithm will give the exact solution. Hence the proposed algorithm provides an efficient complexity verses accuracy tradeoff. The main advantages of the proposed algorithm is that high band and the low band coefficients can be exploited for several classes of signals resulting in very low computation.
Perkembangan Transaksi Bisnis E-Commerce terhadap Pertumbuhan Ekonomi di Indonesia
Authors: Nasution Eri Yanti , Hariani Prawidya , Hasibuan Lailan Safina , Pradita Wita 
Published: December 2021

Teknologi Informasi dan Komunikasi (TIK) sudah menjadi kebutuhan di zaman sekarang ini, banyak masyarakat di Indonesia yang sudah memanfaatkannya dalam kehidupan sehari-hari. Dinamika perekonomian tidak terlepas dari perkembangan serta kemajuan teknologi, infrastruktur, produktifitas dan inovasi. Kemajuan ilmu pengetahuan memberikan dampak dalam kemajuan teknologi. Disruptive innovation menciptakan pasar sendiri yang berlanjut pada sektor bisnis digital (E-commerce). Perkembangan teknologi juga diiringi dengan perkembangan cara menyampaikan informasi dalam berkomunikasi sehingga aktivitas menjadi lebih cepat dengan menggunakan internet dengan aplikasi sosial media. Penelitian ini bertujuan untuk analisis deskriptif perkembangan E-Commerce melalui dan mengestimasi pengaruh bisnis sektor E-Commerce terhadap pertumbuhan ekonomi Indonesia periode 2007-2016. Data yang digunakan dalam variabel ini adalah data sekunder yang diambil dari Badan Pusat Statistik, APJII (Asosiasi Pengguna Jasa Internet Indonesia). Hasil penelitian dengan menggunakan model time serries dengan tehnik OLS (Ordinary Least Square) menunjukkan perkembangan peningkatan bisnis E-commerce cukup besar dalam mendukung pertumbuhan sektor telekomunikasi dan informasi yang memberikan kontribusi sebesar 8% dari total GDP Indonesia ditahun 2016. UMKM yang menjadi tulang punggung ekonomi Indonesia juga menunjukkan potensinya untuk berperan dalam menggerakkan ekonomi digital nasional. Variabel GDP, Jumlah Pengguna internet (JPI) berpengaruh positif dan signifikan terhadap Pertumbuhan Ekonomi di Indonesia, begitu juga dengan Jumlah Nilai Transaksi e-Commerce (JNTE) berpengaruh positif dan signifikan terhadap pertumbuhan ekonomi pada era digital
Pengembangan Aplikasi E-Reimbursement Karyawan Berbasis Android Pada PT Bringin Inti Teknologi
Authors: Widodo Yohanes Bowo , Anindya Aulia , Sutabri Tata 
Published: December 2021

Aplikasi E-Reimbursement merupakan aplikasi online berbasis Android yang berfungsi sebagai sarana klaim atau reimbursement karyawan PT Bringin Inti Teknologi. Kondisi pendemi saat ini yang mengharuskan karyawan dan atasan melakukan Work From Home demi mengikuti peraturan pemerintah. Hal tersebut membuat proses reimbursement bisa tertunda karna diperlukannya dokumen fisik dan tanda tangan basah di atas laporan. Namun dengan adanya aplikasi E-Reimbursement karyawan dengan mudah dan cepat dapat melakukan proses reimbursement karena bisa dilakukan secara online. Aplikasi ini dikembangkan menggunakan Android Studio dan Bahasa pemrograman yang digunakan adalah Java serta sistem manajemen basis data menggunakan MySQL.Hasil yang diharapkan dari aplikasi ini adalah agar proses reimbursement dapat berjalan dengan cepat dan efektif tapi tetap disesuaikan dengan standar operasional perusahaan yang sedang berlaku saat ini. Diharapkan juga kedepannya tidak terjadi duplikasi penyimpanan arsip untuk dokumen reimbursement karena data reimbursement sudah tersimpan di database. Selain meminimalisir penggunaan ruang arsip yang berlebih, pencarian dokumen reimbursement saat diperlukan bisa melalui database tanpa harus membuka dokumen fisik.
Analisis Perbandingan Serverless Computing Pada Google Cloud Platform
Authors: Barokah Ilmi , Asriyanik Asriyanik 
Published: December 2021

Serverless computing menjadi paradigma tren baru di cloud komputasi, memungkinkan pengembang untuk fokus pada aplikasi inti logika dan aplikasi prototipe cepat. Serverless computing memiliki biaya yang lebih rendah dan kenyamanan yang diberikannya kepada pengguna yang tidak perlu fokus pada manajemen server. Karena prospeknya yang bagus Serverless computing, dalam beberapa tahun terakhir, sebagian besar vendor cloud utama telah meluncurkan platform komputasi tanpa server komoditas mereka. Namun, karakteristik platform ini belum dipelajari secara sistematis. Perlunya analisis platform ini secara kualitatif yaitu mulai dari pengembangan, penyebaran, dan aspek runtime untuk membentuk taksonomi karakteristik. Google Cloud Platform memiliki beberapa jenis serverless Computing, dalam artikel ini akan dijelaskan mengenai perbandingan antara beberapa Serverless Computing yaitu diantaranya Cloud Functions, App Engine, Cloud Run,dan Google Kuberenetes Engine (GKE).
Is Duration of Endotracheal Tube Intubation Using a Video Laryngoscope Different with a Direct Laryngoscope in Elective Surgery Patients During Pandemic Covid-19?
Authors: Zaky Hasan  , Zulkifli  , Agustina Br Haloho  , Irfannuddin  
Published: December 2021

Introduction: Aerosol box is a usefull tools to prevent aerosol and droplet contaminations during laryngoscopy and intubation in COVID-19 pandemic. Video laryngoscope is recommended during this era to increase the operator and patient’s distance during the procedure. However, many anesthesiologists still use direct laryngoscopes due to their availability and familiarity. This study aims to compare endotracheal tube intubation with video laryngoscope compared to direct laryngoscope in elective surgery patients.
Methods: This study was a quasi-experimental study. The sample size in each group (video and direct laryngoscope) was 35 subjects. The primary outcome of this study was to compare the duration of intubation between video laryngoscope and direct laryngoscope, while the secondary outcome was to evaluate complications such as broken teeth and sore throat 24 hours post intubation.
Results: Direct laryngoscope had shorter intubation duration than video laryngoscope [12.3 (8.9-21.0) vs 13.3 (11.4 – 21.6; p =0.07) respectively. Two complication reported on video laryngoscope groups.
Conclusion: Duration of ETT intubation using a direct laryngoscope was shorter during intubation with aerosol box compared to video laryngoscope in elective surgery patients. The box which was being used may limit the space of movement making it difficult to intubate.