bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical use of hyaluronic acid in andrology: A review
Authors: Zucchi Alessandro , Scroppo Fabrizio Ildefonso , Capogrosso Paolo , Salonia Andrea , Durante Jacopo , Bini Vittorio , Liguori Giovanni , Bartoletti Riccardo 
Published: July 2021

AbstractBackgroundHyaluronic acid is a glycosaminoglycan widely used in the fields of orthopedics, ophthalmology, and aesthetic medicine due to its significant ability to reduce the synthesis of pro‐inflammatory proteins and its activity against oxidative stress, a feature of many degenerative illnesses.ObjectivesThe objective of the present review is to provide a comprehensive narrative review of the most recent literature on the use of hyaluronic acid in andrology in order to facilitate the use of this therapeutic device in the common clinical practice of many physicians. Specific conditions covered in the review are Peyronie's disease, premature ejaculation, and penile enlargement.Materials and methodsA broad and comprehensive literature search included Medline, EMBASE, and the Cochrane Libraries, with no time restriction up to December 2020 and restricted to English language publications. Unpublished studies were not included. The study was registered as “The role of hyaluronic acid in andrology: A systematic review and meta‐analysis” in PROSPERO with the ID CRD42021223416.Discussion and conclusionHyaluronic acid is a valid choice for the treatment of Peyronie's disease in terms of the resolution of the acute phase of the disease and of contributing to stabilizing the disease as a bridge to potential surgery. Data, furthermore, suggest that hyaluronic acid is frequently associated with an overall clinical improvement, allowing the patient to resume normal sexual activity.With regard to premature ejaculation, data suggests hyaluronic acid‐based treatments were effective in prolonging intra‐vaginal ejaculation time. Furthermore, hyaluronic acid was found to be safe and well‐tolerated, with main adverse events limited to local discomfort, ecchymosis, papule formation, and glans numbness, all of which were reported to resolve spontaneously.Last, with regard to penile enlargement, the overall perception of experts is that hyaluronic acid may be an extremely well‐tolerated compound with potential for application in specific areas of male sexual health that are often neglected as compared to more common, and relatively simpler to treat, conditions.
Gender incongruence in Denmark, a quantitative assessment
Authors: Hilden Malene , Glintborg Dorte , Andersen Marianne Skovsager , Kyster Natacha , Rasmussen Steen Christian , Tolstrup Anders , Lidegaard Øjvind 
Published: July 2021

AbstractIntroductionThe number of persons with gender incongruence referred to health care is increasing, but national data on the incidence of gender incongruence are lacking. The aim of this study was to quantify the development in number of individuals with gender incongruence over time and to estimate the national incidence in Denmark.Material and methodsHistorical descriptive cohort study. Individuals older than 18 years with legal sex‐change in their person registration number were achieved from Statistics Denmark, and the National Health Register provided data on contact diagnoses related to gender‐identity conditions. By combining these two data sources, we made estimates on incidence and incidence rates for individuals with gender incongruence in Denmark through a 41‐year period 1980–2020.ResultsThrough 1980–2020, the annual number of legal sex‐changes increased in individuals assigned female at birth from 5 to approximately 170 and among individuals assigned male at birth from 10 to approximately 150. The cumulative number of legal sex‐changes at the end of 2019 was 1275 assigned female at birth and 1422 assigned male at birth and 66% of the legal sex‐changes were in individuals below 30 years. Correspondingly, the annual number of contacts with the healthcare system due for gender‐identity‐related conditions increased from 30 during 1990–1999 to around 500 in 2017 (both genders combined), with a 10‐fold increase from 2010 to 2017.ConclusionsThe number of legal sex‐changes and healthcare contacts due to gender‐identity‐related diagnoses increased substantially over the last 40 years with a more than 10‐fold increase during the last decade. This calls for research on possible explanations for this increase, for research on the short‐term and long‐term health consequences of hormonal and surgical treatment regimens and for ensuring adequate healthcare facilities.
Child health professionals' experiences of the introduction and successful implementation of rotavirus vaccination in Sweden
Authors: Stenmarker Margaretha , Oldin Carin , Golsäter Marie , Blennow Margareta , Enskär Karin , Nilsson Mats P. , Schollin Ask Lina 
Published: July 2021

AbstractAimTo explore child health professionals' experiences of the early implementation of the rotavirus vaccination in the two regions that first introduced this vaccination in Sweden.MethodsA descriptive and repeated cross‐sectional study based on a digital study‐specific questionnaire with a baseline in 2014 and with a 2‐year follow‐up in 2016. The study population consisted of nurses and doctors working in child health centres in the health care regions of Stockholm and Jönköping.ResultsIn Stockholm, a larger proportion of the respondents (n = 355) had concerns in 2014, in comparison with the respondents in Jönköping (n = 101), mostly about the vaccination being a new and time‐consuming task (60% versus 23%). In 2016, the overall attitude to vaccination was more positive in both regions and the levels of concern about increased workload were reduced (Stockholm, n = 519, 39%, versus Jönköping, n = 96, 10%). Challenges before and after the introduction in both regions were particularly related to how to give information about the vaccine's potential increased risk of intussusception.ConclusionThe gap between respondents' knowledge, attitudes and concerns pre‐ and post‐vaccination introduction was larger in Stockholm compared to Jönköping. In both regions, overall, the implementation of the rotavirus vaccination was perceived as being easier than expected.
Review article: distinctions between ileal and colonic Crohn's disease: from physiology to pathology
Authors: Pierre Nicolas , Salée Catherine , Vieujean Sophie , Bequet Emeline , Merli Angela‐Maria , Siegmund Britta , Meuwis Marie‑Alice , Louis Edouard 
Published: July 2021

SummaryBackgroundIleal and colonic Crohn's disease seem to be two separate entities.AimsTo describe the main physiological distinctions between the small and the large intestine and to analyse the differences between ileal and colonic Crohn's disease.MethodsThe relevant literature was critically examined and synthesised.ResultsThe small and large intestine have fundamental distinctions (anatomy, cellular populations, immune defence, microbiota). The differences between ileal and colonic Crohn's disease are highlighted by a heterogeneous body of evidence including clinical features (natural history of the disease, efficacy of treatments, and monitoring), epidemiological data (smoking status, age, gender) and biological data (genetics, microbiota, immunity, mesenteric fat). However, the contribution of these factors to disease location remains poorly understood.ConclusionThe classification of ileal and colonic Crohn's disease as distinct subphenotypes is well supported by the literature. Understanding of these differences could be exploited to develop more individualised patient care.
Impression management tactics in the CEO statements of Turkish sustainability reports
Authors: Ozsozgun Caliskan Arzu , Esen Emel , Barkemeyer Ralf 
Published: July 2021

AbstractIn this study, we construct a classificatory scheme of impression management tactics and apply it to a sample of sustainability report and annual report CEO statements issued by large Turkish companies. We find a wide range of impression management tactics applied in both types of CEO statements. However, impression management in sustainability report CEO statements emerges as more limited and uniform, revealing clearer prioritizations of impression management tactics when compared to annual report CEO statements. Sustainability report CEO statements emphasize tactics that allow the company to highlight carefully selected, isolated aspects of their sustainability engagement. At the same time, they rarely employ tactics that are geared towards more systematic (quantitative) performance evaluation. We attribute these differences to the way in which corporate sustainability performance is commonly conceptualized and evaluated, emphasising qualitative performance dimensions rather than the reporting of quantitative performance metrics. This results in the application of a different impression management tactics mix and limits the usefulness of sustainability reports as an accountability mechanism when compared to corporate annual reports. In addition, we provide tentative evidence for the context‐specific nature of impression management, with the choice of impression management tactics reflecting the institutional environment a company is based in.
Appropriation of adaptive literacy games into the German elementary school classroom
Authors: Pflaumer Nadine , Knorr Nancy , Berkling Kay 
Published: July 2021

AbstractThe study presented here was aimed at understanding how teachers go about appropriating technology from the iRead EU Horizon 2020 Project into the classroom. iRead provides an adaptive personalised literacy game called Navigo that is deployed in tablets and intended for regular usage in the elementary school classroom. In our case, the game was provided for beginning readers of German. The goal of iRead was to develop these games and then understand how these can be deployed successfully into the classroom. The adaptation of technology by teachers has been a well‐studied phenomenon for decades in some countries. However, in Germany, elementary schools lag behind in digitalisation, making such studies more difficult, resulting in a knowledge gap this study seeks to fill. Appropriation of the Navigo game by the teachers was studied through a series of semi‐formal interviews with 21 teachers from 9 schools, scheduled at the beginning, middle and end of the project, resulting in a total of 55 interviews. Results show that teachers had similar experiences within the project, and faced common stumbling blocks, such as (a) technology, (b) digital literacy and (c) understanding the pedagogical use of adaptive learning games. While teachers generally accepted that interacting with tablets taught pupils the important skill of digital literacy, most teachers did not fully understand how pupils acquired language skills through Navigo. Those teachers who understood the academic benefit of the learning game appropriated Navigo fully by purposefully leveraging the adaptivity of the games to support pupils in a personalised manner. Using thematic analysis and automatic clustering of keyword occurrences in the interviews, we were able to identify four ‘personas’ on the continuum of teacher characteristics. Mapping teachers to these ‘personas’ determined the level of support required during the appropriation process. It was shown that the ‘personas’ are relatively stable and can be identified within the first weeks of appropriation to ensure a successful process as soon as possible.
Practitioner notesWhat is already known about this topic

Appropriation of technology models.

Technology use in school for older pupils.

Educational games outside of school.

What this paper adds

A view on technology usage in elementary schools particular to the German context with large amount of teacher interviews from diverse schools.

Personas that can be identified early on in the process of appropriation based on simple interviews.

Particular challenges of using adaptive technology in the classroom.

Implications for practice and/or policy

A simple model for picking appropriate teacher support in appropriation.

Results show a clear need for improving technology support in the schools.

Teacher training must include digital competence and openness to the idea of independent learning paths.
Positive and negative aspects of mental health after unspecified living kidney donation: A cohort study
Authors: Massey Emma K. , Pronk Mathilde C. , Zuidema Willij C. , Weimar Willem , van de Wetering Jacqueline , Ismail Sohal Y. 
Published: July 2021

ObjectivesUnspecified donors give a kidney to a stranger with end‐stage kidney failure. There has been little research on the long‐term impact of unspecified donation on mental health outcomes. The aim of this study was to assess the positive and negative aspects of mental health among unspecified donors.DesignWe invited all unspecified donors who donated a kidney between 2000 and 2016 at our centre to participate in an interview and to complete validated questionnaires.MethodsWe measured positive mental health using the Dutch Mental Health Continuum‐Short Form (MHC‐SF), psychological complaints using the Symptoms Checklist‐90 (SCL‐90) and psychiatric diagnoses using the Mini‐International Neuropsychiatric Interview (M.I.N.I.) Screen for all donors and the M.I.N.I. Plus on indication.ResultsOf the 134 eligible donors, 114 participated (54% female; median age 66 years), a median of 6 years post‐donation. Scores on emotional and social well‐being subscales of the MHC‐SF were significantly higher than in the general population. Psychological symptoms were comparable to the general population. Thirty‐two per cent of donors had a current or lifetime psychiatric diagnosis. Psychological symptoms did not significantly change between the pre‐donation screening and the post‐donation study.ConclusionsWe concluded that, with the appropriate screening, unspecified donation is a safe procedure from a psychological perspective.
On some relations between a continuous time Luenberger productivity indicator and the Solow model
Authors: Briec Walter , Lasselle Laurence 
Published: July 2021

ABSTRACTWe introduce well‐known microeconomics productivity measures in Solow models in discrete time or continuous time by adopting a Luenberger‐type approach. In each framework, we derive the productivity indicators and the dynamical paths. First, we show that the expression of the productivity indicators are similar to the well‐known Solow residuals, allowing us to make an analogy between a firm's behavior in a microeconomic setting and a country's behavior in a macroeconomic setting. Second, we demonstrate that the properties of the paths are similar in both frameworks.
Molecular imaging of arterial and venous thrombosis
Authors: Wang Xiaowei , Ziegler Melanie , McFadyen James D. , Peter Karlheinz 
Published: July 2021

Thrombosis contributes to one in four deaths worldwide and is the cause of a large proportion of mortality and morbidity. A reliable and rapid diagnosis of thrombosis will allow for immediate therapy, thereby providing significant benefits to patients. Molecular imaging is a fast‐growing and captivating area of research, in both preclinical and clinical applications. Major advances have been achieved by improvements in three central areas of molecular imaging: ‐ (1) better markers for diseases, with increased sensitivity and selectivity, (2) optimised contrast agents with improved signal to noise ratio and (3), progress in scanner technologies with higher sensitivity and resolution. Clinically available imaging modalities used for molecular imaging include magnetic resonance imaging (MRI), X‐ray computed tomography (CT), ultrasound, as well as nuclear imaging, such as positron emission tomography (PET) and single‐photon emission computed tomography (SPECT). In the preclinical imaging field, optical (fluorescence and bioluminescent) molecular imaging has provided new mechanistic insights in the pathology of thromboembolic diseases. Overall, the advances in molecular imaging, driven by the collaboration of various scientific disciplines, have substantially contributed to an improved understanding of thrombotic disease and raise the exciting prospect of earlier diagnosis and individualised therapy for cardiovascular diseases. As such, these advances hold significant promise to be translated to clinical practice and ultimately to reduce mortality and morbidity in patients with thromboembolic diseases.LINKED ARTICLESThis article is part of a themed issue on Molecular imaging ‐ visual themed issue. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.21/issuetoc
Operational challenges in the COVID‐19 era: Asymptomatic infections and vaccination timing
Authors: Axelrod David A. , Ince Dilek , Harhay Meera N. , Mannon Roslyn B. , Alhamad Tarek , Cooper Matthew , Josephson Michelle A. , Caliskan Yasar , Sharfuddin Asif , Kumar Vineeta , Guenette Alexis , Schnitzler Mark A. , Ainapurapu Sruthi , Lentine Krista L. 
Published: July 2021

AbstractThe coronavirus disease 2019 (COVID‐19) pandemic has created unprecedented challenges for solid organ transplant programs. While transplant activity has largely recovered, appropriate management of deceased donor candidates who are asymptomatic but have positive nucleic acid testing (NAT) for SARS‐CoV‐2 is unclear, as this result may reflect active infection or prolonged viral shedding. Furthermore, candidates who are unvaccinated or partially vaccinated continue to receive donor offers. In the absence of robust outcomes data, transplant professionals at US adult kidney transplant centers were surveyed (February 13, 2021 to April 29, 2021) to determine community practice (N: 92 centers, capturing 41% of centers and 57% of transplants performed). The majority (97%) of responding centers declined organs for asymptomatic NAT+ patients without documented prior infection. However, 32% of centers proceed with kidney transplant in NAT+ patients who were at least 30 days from initial diagnosis with negative chest imaging. Less than 7% of programs reported inactivating patients who were unvaccinated or partially vaccinated. In conclusion, despite national recommendations to wait for negative testing, many centers are proceeding with kidney transplant in patients with positive SARS‐CoV‐2 NAT results due to presumed viral shedding. Furthermore, few centers are requiring COVID‐19 vaccination prior to transplantation at this time.
Impact of induction therapy on outcomes after heart transplantation
Authors: Tzani Aspasia , Van den Eynde Jef , Doulamis Ilias P. , Kuno Toshiki , Kampaktsis Polydoros N. , Alvarez Paulino , Briasoulis Alexandros 
Published: July 2021

AbstractBackgroundApproximately 50% of heart transplant (HT) programs utilize induction therapy (IT) with interleukin‐2 receptor antagonists (IL2RA) or polyclonal anti‐thymocyte antibodies (ATG).MethodsAdult HT recipients were identified in the UNOS Registry between 2010 and 2020. We compared mortality between IT strategies with competing risk analysis.ResultsA total of 28 634 HT recipients were included in the study (50.1% no IT, 21.3% ATG, 27.9% IL2RA, .7% alemtuzumab, .01% OKT3). Adjusted all‐cause, 30 day and 1 year mortality were lower among those treated with IT than no IT (sub‐hazard ratio [SHR] .87, 95% CI .79–.96, SHR .86, .76–.97, SHR .76, .63–.93, P = .007, respectively). In propensity score matching analysis IT was associated with lower 30‐day and 1‐year mortality. IL2RA had higher all‐cause and 1‐year mortality than ATG (SHR 1.41, 95% CI 1.23–1.69 and 1.55, 95% CI 1.29–1.88, respectively). Utilization of IT was associated with significantly lower risk of treated rejection at 1 year after HT compared with no IT (relative risk ratio [RRR] .79) and similarly ATG compared with IL2RA (RRR .51).ConclusionIT was associated with lower mortality and treated rejection episodes than no IT. IL2RA is the most used IT approach but ATG has lower risk of treated rejection and mortality.
Health‐related quality of life and caregiver burden after hip reconstruction and spinal fusion in children with spastic cerebral palsy
Authors: DiFazio Rachel L , Vessey Judith A , Miller Patricia E , Snyder Brian D , Shore Benjamin J 
Published: July 2021

AimTo evaluate the effect of hip reconstruction or spinal fusion on health‐related quality of life (HRQoL) in non‐ambulatory children with spastic cerebral palsy (CP) and caregiver burden.MethodThis was a prospective, longitudinal study of changes in HRQoL and caregiver burden over the 5 years after surgical correction of hip instability or scoliosis in children with bilateral spastic CP classified in Gross Motor Function Classification levels IV or V. Serial parent proxy measures of HRQoL and caregiver burden were obtained before and 6 weeks, and 3, 6, 9, 12, 24, and 60 months after surgery using the Caregiver Priorities and Child Health Index of Life with Disabilities and the Assessment of Caregiver Experience with Neuromuscular Disease. Scores 5 years or more after surgery were compared to pre‐surgery scores using paired Student’s t‐tests. Serial outcome trajectories were estimated by linear mixed modeling.ResultsOf 69 participants (40 males, 29 females; mean age 11y 6mo, SD 4y 1mo, range 3y 10mo–20y 7mo), 43 had hip reconstruction and 26 had spinal fusion. Clinically significant improvements in HRQoL were detected (average increase 7.6 points) 5 years or more postoperatively, with hip reconstruction providing greater benefit. Domains improved by surgery included positioning, transferring/mobility, comfort/emotions, and health. Caregiver burden did not change as these children remain maximally dependent.InterpretationSurgical treatment of hip and spine deformity improves HRQoL, especially for painful hip instability, but does not change caregiver burden.
Learning management system‐integrated spreadsheet exercises for facility location modeling
Authors: Strakos Joshua K. , Brazhkin Vitaly 
Published: July 2021

AbstractSupply chain management students are introduced to a variety of modeling concepts. Yet learning facility location and capacity allocation modeling to the level of application and mastery proves difficult for the typical undergraduate business student. Spreadsheets facilitate the teaching of optimization modeling; however, providing feedback to students on spreadsheet assignments is an onerous and time‐consuming task for instructors. In this teaching brief, a set of learning management system (LMS)‐integrated spreadsheet exercises is presented which helps students learn spreadsheet modeling for the capacitated plant location problem. These exercises are also designed to reduce the instructor's grading burden while providing timely feedback and assessment of student performance. The effectiveness of the exercises is demonstrated by assessment data gathered from the LMS as well as postmodule student survey results.