bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transdiagnostic phenotyping of psychopathology in a help-seeking population (PhenoNetz): A study protocol for an experience sampling study
Authors: Rosen Marlene , Betz Linda T. , Montag Christian , Kannen Christopher , Kambeitz Joseph 
Published: May 2021

AbstractPrevention in psychiatry provides a promising way to address the burden by mental illness. However, established approaches focus on specific diagnoses and do not address the heterogeneity and manifold potential outcomes of help-seeking populations that present at early recognition services. Conceptualizing psychopathology manifested in help-seeking populations from a network perspective of interacting symptoms allows transdiagnostic investigations beyond binary disease categories. Furthermore, modern technologies such as smartphones facilitate the application of Experience Sampling Methods (ESM). A combination of ESM with network analyses provides valid insights beyond established assessment instruments. We will examine n = 75 individuals (age 18-40 years) of the help-seeking population of the Cologne early recognition centre (FETZ). For a maximally naturalistic sample, only minimal exclusion criteria will be applied. We will collect data for 14 days utilizing a mobile application to assess ten transdiagnostic symptoms, i.e., depressive, anxious and psychotic symptoms as well as distress level. With these data, we will generate average group-level symptom networks and personalized symptom networks using a two-step multilevel vector autoregressive model. Additionally, we will explore associations between symptom networks and sociodemographic, risk and resilience factors, as well as psychosocial functioning. Our study will provide insights about feasibility and utility of ESM in a help-seeking population. Providing a first explorative phenotyping of the transdiagnostic help-seeking population, this study will contribute to innovation of early recognition in psychiatry. Results will help to pave the way for prevention and targeted early intervention in a broader patient group and thus, enable greater intended effects in alleviating the burden of psychiatric disorders.
Establishment of CRISPR/Cas9-based knock-in in a hemimetabolous insect: targeted gene tagging in the cricketGryllus bimaculatus
Authors: Matsuoka Yuji , Nakamura Taro , Watanabe Takahito , Barnett Austen A. , Tomonari Sayuri , Ylla Guillem , Whittle Carrie A. , Noji Sumihare , Mito Taro , Extavour Cassandra G. 
Published: May 2021

AbstractStudies of traditional model organisms like the fruit flyDrosophila melanogasterhave contributed immensely to our understanding of the genetic basis of developmental processes. However, the generalizability of these findings cannot be confirmed without functional genetic analyses in additional organisms. Direct genome editing using targeted nucleases has the potential to transform hitherto poorly-understood organisms into viable laboratory organisms for functional genetic study. To this end, here we present a method to induce targeted genome knock-out and knock-in of desired sequences in an insect that serves as an informative contrast toDrosophila, the cricketGryllus bimaculatus. The efficiency of germ line transmission of induced mutations is comparable to that reported for other well-studied laboratory organisms, and knock-ins targeting introns yield viable, fertile animals in which knock-in events are directly detectable by visualization of a fluorescent marker in the expression pattern of the targeted gene. Combined with the recently assembled and annotated genome of this cricket, this knock-in/knock-out method increases the viability ofG. bimaculatusas a tractable system for functional genetics in a basally branching insect.
Endoplasmic Reticulum morphological regulation by RTN4/NOGO modulates neuronal regeneration by curbing luminal transport
Authors: Konno Tasuku , Parutto Pierre , Bailey David M. D. , Davì Valentina , Crapart Cécile , Awadelkareem Mosab Ali , Hockings Colin , Brown Aidan , Xiang Katherine M. , Agrawal Anamika , Chambers Joseph E. , Werp Molly Vander , Koning Katherine , Metzakopian Emmanouil , Westrate Laura , Koslover Elena , Avezov Edward 
Published: May 2021

AbstractCell and tissue functions rely on an elaborate intracellular transport system responsible for distributing bioactive molecules with high spatiotemporal accuracy. The tubular network of the Endoplasmic Reticulum (ER) constitutes a system for the delivery of luminal solutes it stores, including Ca2+, across the cell periphery. The physical nature and factors underlying the ER’s functioning as a fluidics system are unclear. Using an improved ER transport visualisation methodology combined with optogenetic Ca2+ dynamics imaging, we observed that ER luminal transport is modulated by natural ER tubule narrowing and dilation, directly proportional to the amount of an ER membrane morphogen, Reticulon 4 (RTN4). Consequently, the ER morphoregulatory effect of RTN4 defines ER’s capacity for peripheral Ca2+ delivery and thus controls axonogenesis. Excess RTN4 limited ER luminal transport, Ca2+ release and iPSC-derived cortical neurons’ axonal extension, while RTN4 elimination reversed the effects.SummaryIntracellular transport through the lumen of the ER network is modulated through narrowing/dilation of ER tubules by a membrane morphogen – RTN4, a process controlling axonogenesis by limiting the delivery of ER-stored Ca2+.
Molecular and cellular architecture of the larval sensory organ in the cnidarian Nematostella vectensis
Authors: Teeling Callum , Gilbert Eleanor , Pedersen Siffreya , Chrismas Nathan , Modepalli Vengamanaidu 
Published: May 2021

AbstractThe apical pole of eumetazoan ciliated larvae acts as a neurosensory structure and is principally composed of sensory-secretory cells. Cnidarians like the sea anemone Nematostella vectensis are the only non-bilaterian group to evolve ciliated larvae with a neural integrated sensory organ that is likely homologous to bilaterians. Here, we uncovered the molecular signature of the larval sensory organ in Nematostella by generating a transcriptome of the apical tissue. We characterised the cellular identity of the apical domain by integrating larval single-cell data with the apical transcriptome and further validated this through in-situ hybridisation. We discovered that the apical domain comprises a minimum of 6 distinct cell types, including apical cells, neurons, peripheral flask-shaped gland/secretory cells, and undifferentiated cells. By profiling the spatial expression of neuronal genes, we showed that the apical region has a unique neuronal signature distinct from the rest of the body. By combining the planula cilia proteome with the apical transcriptome data, we revealed the sheer complexity of the non-motile apical tuft. Overall, we present comprehensive spatial/molecular data on the Nematostella larval sensory organ and open new directions for elucidating the functional role of the apical organ and larval nervous system.
Cis-regulatory divergence underpins the evolution of C3-C4 intermediate photosynthesis in Moricandia
Authors: Lin Meng-Ying , Schlüter Urte , Stich Benjamin , Weber Andreas P.M. 
Published: May 2021

AbstractAltered transcript abundances and cell specific gene expression patterns that are caused by regulatory divergence play an important role in the evolution of C4 photosynthesis. How these altered gene expression patterns are achieved and whether they are driven by cis- or trans-regulatory changes is mostly unknown. To address this question, we investigated the regulatory divergence between C3 and C3-C4 intermediates, using allele specific gene expression (ASE) analyses of Moricandia arvensis (C3-C4), M. moricandioides (C3) and their interspecific F1 hybrids. ASE analysis on SNP-level showed similar relative proportions of regulatory effects among hybrids: 36% and 6% of SNPs were controlled by cis-only and trans-only changes, respectively. GO terms associated with metabolic processes and the positioning of chloroplast in cells were abundant in transcripts with cis-SNPs shared by all studied hybrids. Transcripts with cis-specificity expressed bias toward the allele from the C3-C4 intermediate genotype. Additionally, ASE evaluated on transcript-level indicated that ∼27% of transcripts show signals of ASE in Moricandia hybrids. Promoter-GUS assays on selected genes revealed altered spatial gene expression patterns, which likely result from regulatory divergence in their promoter regions. Assessing ASE in Moricandia interspecific hybrids contributes to the understanding of early evolutionary steps towards C4 photosynthesis and highlights the impact and importance of altered transcriptional regulations in this process.
Neuropsychological evidence of multi-domain network hubs in the human thalamus
Authors: Hwang Kai , Shine James M. , Bruss Joel , Tranel Daniel , Boes Aaron D. 
Published: May 2021

AbstractHubs in the human brain support behaviors that arise from brain network interactions. Previous studies have identified hub regions in the human thalamus that are connected with multiple functional networks. However, the behavioral significance of thalamic hubs has yet to be established. Our framework predicts that thalamic subregions with strong hub properties are broadly involved in functions across multiple cognitive domains. To test this prediction, we studied human patients with focal thalamic lesions in conjunction with network analyses of the human thalamocortical functional connectome. In support of our prediction, lesions to thalamic subregions with stronger hub properties were associated with widespread deficits in executive, language, and memory functions, whereas lesions to thalamic subregions with weaker hub properties were associated with more limited deficits. These results highlight how a large-scale network model can broaden our understanding of thalamic function for human cognition.
The job rotation scheduling problem considering human cognitive effects: an integrated approach
Authors: Ayough Ashkan , Farhadi Farbod , Zandieh Mostafa 
Published: May 2021

Purpose
This paper aims to unfold the role that job rotation plays in a lean cell. Unlike many studies, the authors consider heterogeneous operators with dynamic performance factor that is impacted by the assignment and scheduling decisions. The purpose is to derive an understanding of the underlying effects of job rotations on performance metrics in a lean cell. The authors use an optimization framework and an experimental design methodology for sensitivity analysis of the input parameters.

Design/methodology/approach
The approach is an integration of three stages. The authors propose a set-based optimization model that considers human behavior parameters. They also solve the problem with two meta-heuristic algorithms and an efficient local search algorithm. Further, the authors run a post-optimality analysis by conducting a design of experiments using the response surface methodology (RSM).

Findings
The results of the optimization model reveal that the job rotation schedules and the human cognitive metrics influence the performance of the lean cell. The results of the sensitivity analysis further show that the objective function and the job rotation frequencies are highly sensitive to the other input parameters. Based on the findings from the RSM, the authors derive general rules for the job rotations in a lean cell given the ranges in other input variables.

Originality/value
The authors integrate the job rotation scheduling model with human behavioral and cognitive parameters and formulate the problem in a lean cell for the first time in the literature. In addition, they use the RSM for the first time in this context and offer a post-optimality analysis that reveals important information about the impact of the job rotations on the performance of operators and the entire working cell.
Dynamic capabilities: interrelations and distinct effects on performance in low and high competitive intensity environments
Authors: Markovich Amiram , Efrat Kalanit , Raban Daphne R. 
Published: May 2021

PurposeThis study aims to augment the understanding of dynamic capabilities (DCs) by exploring the interrelations among the DC categories (sensing, seizing, reconfiguring) and the distinct impact of each DC on firm performance under low and high levels of competitive intensity.Design/methodology/approachThe analysis is based on a cross-sectional survey of 139 managers in Israel. The data were collected through Web-based questionnaires using the Qualtrics software. A two-stage data analysis was performed using structural equation modeling (SEM).FindingsThe findings indicate that DCs follow a sequence in which sensing drives seizing, which, in turn, enhances reconfiguring. The effects of sensing are mainly manifested through its direct impact on seizing, with no evidence for an impact of sensing on company performance. Moreover, under low competitive intensity, only seizing appears to impact performance, while under high competitive intensity, reconfiguring joins seizing in improving firm performance.Originality/valueThe study's findings advance the debate on the direct vs sequential nature of DCs by indicating an internal DC sequence. Our research also advocates for a crucial role of sensing in enhancing DCs, regardless of the level of competitive intensity. Furthermore, this research expands the understanding of the consequences of DCs and enables the prioritization of DC categories under low and high competitive intensity.
Towards economic sustainability: how higher education can support the business operations of emerging clothing manufacturing micro enterprises
Authors: Strydom Mariette , Kempen Elizabeth 
Published: May 2021

Purpose
This paper aims to investigate the business operations of informal clothing manufacturing micro enterprises (CMMEs) and identifies ways to support owners to achieve economic sustainability.

Design/methodology/approach
A qualitative approach applying a case study design was used to study the business operations of 13 informal CMME owners at a business incubation hub (IH).

Findings
The study found that emerging CMME owners need ongoing generic business and fashion-related field-specific support particular to their business. Such support can be offered through the collaboration between higher education (HE) institutions and business IHs.

Social implications
Starting a clothing manufacturing business offers women in Africa the opportunity to improve both their personal and community well-being contributing to three sustainable development goals, namely, to end poverty, gender equality and empowering women, as well as sustainable consumption and production patterns. Partnering with existing business IHs, HE can influence skills-specific training that may contribute to the economic sustainability of emerging entrepreneurs and reduce poverty.

Originality/value
The study proposes in-house apparel apprenticeships to ensure the economic sustainability of the CMME, contributing to apparel entrepreneurship literature and fashion-based entrepreneurship education.
Show you the money – firms investing in worker safety have better financial performance: insights from a mapping review
Authors: Sousa Saymon Ricardo de Oliveira , Melchior Cristiane , Da Silva Wesley Vieira , Zanini Roselaine Ruviaro , Su Zhaohui , da Veiga Claudimar Pereira 
Published: May 2021

PurposeThis study aims to (1) investigate the association between companies' investment in occupational safety and their financial performance and (2) discuss the importance of occupational safety to overall performance.Design/methodology/approachOccupational safety is often considered to be a practice that can yield suboptimal return on investment. However, it is not known whether this belief is substantiated by evidence. A mapping review of the eligible research literature (N = 36) regarding firms' investment in occupational safety and their financial performance, published between 1945 and2018, was carried out in the Web of Science database.FindingsBy dispelling myths regarding return on investment associated with occupational safety, the findings of this study underscore financial gains firms can obtain by promoting occupational safety measures in their organizations.Originality/valueThese issues are important because they can help policymakers understand the pressures companies face in terms of occupational safety and financial performance sustainability.
Freeports: Innovative trading hubs or centres for money laundering and tax evasion?
Authors: Gilmour Paul Michael 
Published: May 2021

Purpose
This study aims to provide a critical overview of freeports’ trading operations and consider to what extent they may present a money-laundering and tax-evasion risk.

Design/methodology/approach
This study reviews the literature surrounding freeports and offers an up-to-date narrative of their potential money-laundering and tax-evasion activities. The paper relies on secondary data from published sources referencing peer-reviewed papers and “grey-literature” material relating to freeports, offshore finance and anti-money laundering control.

Findings
This study demonstrates the attractive trading advantages offered by freeports to enable enterprise and innovation. However, the study reveals that the secretive offshore space in which freeports operate also helps to obscure beneficial ownership and illicit trade-based practices that frustrate authorities’ efforts to trace laundered monies and recover government taxes. Despite freeports’ trade offerings, stronger regulation is needed to prevent them from being abused for money-laundering and tax-evasion purposes.

Originality/value
This study provides an important insight into the money-laundering and tax-evasion risks presented by freeports and, in doing so, advances the contemporary debate on illicit activities occurring through offshore jurisdictions.
An analysis of the forfeiture regime under the anti-money laundering law
Authors: A. Rahman Aspalella 
Published: May 2021

Purpose
This paper aims to analyze the forfeiture regime under the Malaysian anti-money laundering law. Apart from discussing the relevant provisions, several court cases also were examined to identify the problems which arise in the implementation of such a powerful forfeiture regime.

Design/methodology/approach
This paper mainly relies on statutes and court cases as its primary sources of information. It is supported by secondary data to justify the analysis. This paper also used analytical descriptive approach to analyze relevant forfeiture provisions from statutes and to examine current court cases regarding the implementation of the forfeiture regime.

Findings
The Anti-Money Laundering, Anti-Terrorism Financing and Proceeds of Unlawful Activities Act (AMLATFPUAA) provides comprehensive procedures for the forfeiture of criminal proceeds. Any limitations of the previous statutory legislations have been addressed, and more importantly, the AMLATFPUAA introduces more powerful and innovative measures that can facilitate the recovery of illegal proceeds from money laundering and any other serious crimes. The AMLATFPUAA also provides avenue for the bona fide third parties to contest the forfeiture order. However, it appears that such right is not easy to be enforced.

Originality/value
This paper provides an analysis of the forfeiture regime under Malaysian anti-money laundering laws. It is hoped that the content of this paper can provide some insight into this particular area for enforcement authorities, practitioners, academics, policymakers and legal advisers not only in Malaysia but also elsewhere. The findings of this paper also expose any weakness or lacunae in the aspects of application and implementation of the forfeiture regime. Thus, more effective and workable legal solution especially on the issue of civil forfeiture of criminal assets could be considered for further accomplishment.
To be or not to be equal: the impact of pride on brands associated with dissociative out-groups
Authors: Lu Yue , Wang Zhanqing , Yang Defeng , Kakuda Nakaya 
Published: May 2021

PurposeBrands are increasingly reflecting social values, and many brands have begun to embrace equality and inclusivity as a marketing strategy. Accordingly, consumers are increasingly being exposed to brands associated with different social groups. This paper aims to examine how consumers who have experienced pride respond to brands associated with dissociative out-groups.Design/methodology/approachFour studies were conducted. Study 1 tested the basic effect of how the experience of different facets of pride affects consumers’ brand attitudes toward a brand associated with a dissociative out-group. Studies 2 and 3 examined the underlying mechanism of consumers’ psychological endorsement of egalitarianism using both mediation and moderation approaches. Study 4 derived implications of our findings for marketers.FindingsThe results show that consumers respond differently to a brand associated with a dissociative out-group based on the facets of pride they experience. When consumers experience authentic (vs hubristic) pride, they exhibit a more favorable attitude toward the brand associated with the dissociative out-group. This is because authentic (vs hubristic) pride increases consumers’ psychological endorsement of egalitarianism, which enhances consumers’ brand attitudes toward the brand associated with the dissociative out-group.Practical implicationsThe findings suggest that brand managers should think about ways to elicit consumers’ authentic pride to minimize the potential backlash from consumers when promoting equality and inclusivity in their brand communications, particularly when such communications contain cues of dissociative out-groups.Originality/valueThis paper contributes to the branding literature by identifying pride as an important determinant that can help brands overcome the negative impact of dissociative out-groups on consumers’ brand reactions, enriches the literature on pride by documenting a novel effect of the two facets of pride on consumer behavior and extends the literature of egalitarianism by demonstrating pride as a driver of consumers’ psychological endorsement of egalitarianism.