bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying suitable time periods for infrasound measurement system response estimation using across-array coherence
Authors: Green David N , Nippress Alexandra , Bowers David , Selby Neil D 
Published: April 2021

SUMMARY
Microbarometers deployed to measure atmospheric infrasound are often connected to, or housed within, a wind noise reduction system (WNRS). At infrasound arrays of the International Monitoring System (IMS), being deployed as part of Comprehensive Nuclear-Test-Ban Treaty verification measures, the WNRS typically comprises an 18 m diameter pipe array. Over the past decade an in situ method has been developed to estimate the measurement system (sensor + WNRS) response characteristics, by comparing its recordings with those made on a colocated reference sensor with known response and no WNRS. The method relies upon the identification of time periods for which the reference sensor and measurement system are subject to the same input pressure field. It has proven difficult to reliably identify such time periods at frequencies $\lt 0.1\,$ Hz using recordings at a single location, resulting in a negative bias in estimated measurement system gain values (the ‘dip artefact’) in the 0.02–0.1 Hz passband. The IMS is deploying arrays of microbarometers, and we show that a measure of across-array coherence can be used to identify time periods associated with acoustic signal propagation. Amplitude response estimates, using 1 yr of data from four IMS arrays, indicate that the dip artefact can be removed by retaining for analysis only those time periods that exhibit high across-array coherence. Moreover, our analysis confirms the hypothesis that the dip artefact is associated with time periods during which wind-generated pressure fluctuations dominate, leading to partial suppression of noise with length scales less than the extent of the WNRS. At two arrays within continental forests accurate amplitude responses are estimated across the 0.02–4 Hz passband, as acoustic signals at all frequencies can be identified. At two oceanic island arrays, the low numbers of time windows with above-noise acoustic signal in the 0.02–0.1 Hz passband make reliable response estimation at these frequencies difficult or impossible. It is recommended that the methodology for estimating the response of an infrasound measurement system at an array should incorporate a multichannel coherence measure; data centres may already routinely compute such measures in their signal detection algorithms.
Shear wave splitting measurements in northeastern Uganda and southeastern Tanzania: corroborating evidence for sublithospheric mantle flow beneath East Africa
Authors: Andriampenomanana Fenitra , Nyblade Andrew , Durrheim Raymond , Tugume Fred , Nyago Joseph 
Published: April 2021

SUMMARY
Several interpretations of shear wave splitting measurements in East Africa have been proposed, but a comprehensive understanding of seismic anisotropy is lacking vis-à-vis geodynamic processes affecting the African Plate, in part because of geographically limited data coverage. Here, we report new shear wave splitting observations using PKS, SKS and SKKS phases recorded on 17 temporary AfricaArray seismic stations in northeastern Uganda and southeastern Tanzania that help fill key gaps in data coverage in non-volcanic regions of East Africa. The stations in northeastern Uganda straddle the Aswa shear zone, which separates the Neoproterozoic Saharan Metacraton (to the east) and the Palaeoproterozoic Northern Uganda Terrane (to the west). The stations in southeastern Tanzania are located mostly in Karoo basins formed within the Neoproterozoic Mozambique Belt. Our results show NNE fast polarization directions in northeastern Uganda, with splitting times between 1.0 and 1.5 s, and NE directions in southeastern Tanzania, with splitting times between 0.6 and 1.3 s. The NNE fast polarization directions in Uganda cannot be explained with oriented melt pocket (OMP) anisotropy in the lithosphere, as the stations are far from any volcanic fields, or fossil anisotropy resulting from the Neoproterozoic East African orogeny. They are, however, parallel to the flow direction of the African superplume and corroborate previous measurements from northern Uganda that were used to argue that the overall northerly orientation of fast polarization directions across East Africa can be attributed to sublithospheric mantle flow associated with the African superplume. The NE fast polarization directions in Tanzania cannot be explained with SE-oriented fossil anisotropy expected from the Mesozoic rifting of Madagascar from Africa or OMP anisotropy in the lithosphere. However, they are consistent with the overall northerly orientation of fast polarization directions in East Africa and can be attributed to either fossil anisotropy in the Mozambique Belt lithosphere resulting from the East African Orogeny or sublithospheric mantle flow associated with the African superplume.
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import
Authors: Lin Brian C , Phung Trong H , Higgins Nicole R , Greenslade Jessie E , Prado Miguel A , Finley Daniel , Karbowski Mariusz , Polster Brian M , Monteiro Mervyn J 
Published: April 2021

Abstract
UBQLN2 mutations cause amyotrophic lateral sclerosis (ALS) with frontotemporal dementia (FTD), but the pathogenic mechanisms by which they cause disease remain unclear. Proteomic profiling identified ‘mitochondrial proteins’ as comprising the largest category of protein changes in the spinal cord (SC) of the P497S UBQLN2 mouse model of ALS/FTD. Immunoblots confirmed P497S animals have global changes in proteins predictive of a severe decline in mitochondrial health, including oxidative phosphorylation (OXPHOS), mitochondrial protein import and network dynamics. Functional studies confirmed mitochondria purified from the SC of P497S animals have age-dependent decline in nearly all steps of OXPHOS. Mitochondria cristae deformities were evident in spinal motor neurons of aged P497S animals. Knockout (KO) of UBQLN2 in HeLa cells resulted in changes in mitochondrial proteins and OXPHOS activity similar to those seen in the SC. KO of UBQLN2 also compromised targeting and processing of the mitochondrial import factor, TIMM44, resulting in accumulation in abnormal foci. The functional OXPHOS deficits and TIMM44-targeting defects were rescued by reexpression of WT UBQLN2 but not by ALS/FTD mutant UBQLN2 proteins. In vitro binding assays revealed ALS/FTD mutant UBQLN2 proteins bind weaker with TIMM44 than WT UBQLN2 protein, suggesting that the loss of UBQLN2 binding may underlie the import and/or delivery defect of TIMM44 to mitochondria. Our studies indicate a potential key pathogenic disturbance in mitochondrial health caused by UBQLN2 mutations.
Evaluation of treatment options for postoperative and spontaneous chylothorax in adults
Authors: Wiesner Sigrid , Loch Elena , Uller Wibke , Gößmann Holger , Neu Reiner , Hofmann Hans-Stefan , Ried Michael 
Published: April 2021

Abstract

OBJECTIVES
Both postoperative and spontaneous chylothorax remain therapeutic challenges without recommendations for a standardized treatment approach. Regardless of its aetiology, patients with chylothorax experience prolonged hospitalization and suffer from the associated complications or the invasive therapy administered.

METHODS
We conducted a retrospective, observational review of adult patients with chylothorax treated between January 2010 and September 2019. The primary end point was successful management with sustained cessation and/or controlled chylous output. Therapy duration, inpatient stay and the incidence of complications were evaluated as secondary end points.

RESULTS
Of the 36 patients included (22 men; median age 63 years), 24 patients (67%) suffered from a postoperative accumulation of chylous fluid in the pleural space; in the remaining 12 (33%) patients, chylothoraces occurred spontaneously. Initial conservative treatment was successful in 42% (n = 15); in the other 20 cases (56%) additional invasive therapeutic strategies were followed. A complicated course requiring more than 1 treatment was seen in 54% (n = 13) of the postoperative and in 58% (n = 7) of the spontaneous cases. The median length of hospitalization was significantly longer in the postoperative group (37.5 vs 15.5 days; P = 0.016). Serious complications were observed only in the postoperative group (P = 0.28). There were no in-hospital deaths.

CONCLUSIONS
Basic treatment of both postoperative and spontaneous chylothorax should include dietary measures in all patients. Additional sclerosing radiotherapy and interventional or surgical therapy are often necessary. The choice of therapeutic approach should be indicated, depending on the aetiology and development of the chylothorax. Early, multimodal treatment is recommended.
An automatic approach for detecting building fences from high-resolution images: the case study of Makkah, Saudi Arabia
Authors: Imam Ayman , Faisal Kamil , Majrashi Abdulrahman , Hegazy Ibrahim 
Published: April 2021

Abstract
In the light of the constantly expanding technological advancements concerning high-resolution satellites and imaging techniques for investigative and information uses it is important to look at how these algorithms progress to acquire more reliable data in a much efficient manner. This study aims to (1) investigate the ability to use remote sensing and geographic information system techniques to extract the detecting building edges in the City of Makkah and (2) investigate new machine learning techniques to derive the illegal building fences in the study area. Two WorldView-3 images will be the first obtained for the City of Makkah in 2016 and 2018. Convolutional neural networks algorithm will be investigated to detect all the fences within the two images. These traits have been utilized to create automated object detection techniques, which are a core requirement of information extraction and large frame analysis of images covering large expanses of land. In high-resolution images, object detection identifies objects belonging to a class, locating them using a bounding box. Based on satellite images time series, the outputs will detect the changes that occurred during 2016 and 2018. A web map application will be designed as the primary tool to make it easier, illustrating the differences between the main changes. Evaluation of binary classifiers approach will be used to evaluate the outcomes of building fences based on several performances that measure data interpretation. Preliminary findings will illustrate the precision and accuracy of the used machine learning algorithm. The research findings can contribute to the federal/municipal authorities and act as a generic indicator for targeting building fences for urban areas and/or suburban areas.
Utilization and effects of mobile electronic clinical decision support on pediatric asthma care quality in the emergency department and inpatient setting
Authors: Kerns Ellen , McCulloh Russell , Fouquet Sarah , McDaniel Corrie , Ken Lynda , Liu Peony , Kaiser Sunitha 
Published: April 2021

Abstract

Objective
To determine utilization and impacts of a mobile electronic clinical decision support (mECDS) on pediatric asthma care quality in emergency department and inpatient settings.

Methods
We conducted an observational study of a mECDS tool that was deployed as part of a multi-dimensional, national quality improvement (QI) project focused on pediatric asthma. We quantified mECDS utilization using cumulative screen views over the study period in the city in which each participating site was located. We determined associations between mECDS utilization and pediatric asthma quality metrics using mixed-effect logistic regression models (adjusted for time, site characteristics, site-level QI project engagement, and patient characteristics).

Results
The tool was offered to clinicians at 75 sites and used on 286 devices; cumulative screen views were 4191. Children’s hospitals and sites with greater QI project engagement had higher cumulative mECDS utilization. Cumulative mECDS utilization was associated with significantly reduced odds of hospital admission (OR: 0.95, 95% CI: 0.92–0.98) and higher odds of caregiver referral to smoking cessation resources (OR: 1.08, 95% CI: 1.01–1.16).

Discussion
We linked mECDS utilization to clinical outcomes using a national sample and controlling for important confounders (secular trends, patient case mix, and concomitant QI efforts). We found mECDS utilization was associated with improvements in multiple measures of pediatric asthma care quality.

Conclusion
mECDS has the potential to overcome barriers to dissemination and improve care on a broad scale. Important areas of future work include improving mECDS uptake/utilization, linking clinicians’ mECDS usage to clinical practice, and studying mECDS’s impacts on other common pediatric conditions.
Influence of amount and frequency of protein supplementation to ruminants consuming low-quality cool-season forages: efficiency of nitrogen utilization in lambs and performance of gestating beef cows
Authors: Cappellozza Bruno I , Bohnert David W , Reis Maria M , Van Emon Megan L , Schauer Christopher S , Falck Stephanie J , Cooke Reinaldo F 
Published: April 2021

Abstract
We evaluated the influence of amount and crude protein (CP) supplementation frequency (SF) on nitrogen (N) use by wethers and the performance of late-gestation beef cows. In exp. 1, seven Western whiteface wethers (31.8 ± 1.4 kg) were used in an incomplete 7 × 4 Latin square to evaluate intake and N use. Wethers received one of the seven treatments in a 2 × 3 factorial design containing two levels of supplemental soybean meal offered at a rate of 100% (F) or 50% (H; 50% of F) of the estimated CP requirement daily, once every 5, or once every 10 d, plus a non-supplemented control (CON). Low-quality cool-season forage (4.9 % CP; dry matter [DM] basis) was provided daily for ad libitum intake. Experimental periods lasted 30 d. In exp. 2, 84 Angus × Hereford cows (560 ± 35 kg) were stratified by age, body condition score (BCS), and expected calving date and allocated to 1 of the 21 feedlot pens (three pens per treatment). Pens were randomly assigned to receive the same treatments as in exp. 1 and cows had free access to low-quality cool-season forage (2.9% CP; DM basis). Cow body weight (BW) and BCS were measured every 14 d until calving and within 24 h after calving. In exp. 1, supplementation did not alter total DM and organic matter (OM) intake (P ≥ 0.26), but both parameters linearly decreased as SF decreased (P = 0.02). Supplementation increased DM, OM, and neutral detergent fiber (NDF) digestibility (P ≤ 0.02). Additionally, F feeding linearly increased DM, OM, and NDF digestibility as SF decreased (P ≤ 0.04). Digestibility of N, N balance, and digested N retained were greater with supplementation (P &lt; 0.01), and N digestibility linearly increased as SF decreased (P = 0.01). Mean plasma urea-N concentration was not only greater (P &lt; 0.01) for supplemented vs. CON wethers but also greater (P = 0.03) for F vs. H. In exp. 2, pre-calving BCS change was greater (P = 0.03) for supplemented cows. A linear effect of SF × supplementation rate for pre-calving BCS change was noted (P = 0.05), as F-supplemented cows lost more BCS compared with H as SF decreased. When considering supplementation intervals greater than 5 d, reducing the quantity of supplement provided, compared with daily supplementation, may be a feasible management strategy to maintain acceptable nutrient use and animal performance while reducing supplement and labor costs.
Expanding the Curricula for Florida’s Youth: Outreach Efforts in Agricultural Literacy
Authors: Pinkerton Morgan , Frey Craig , Thompson Sage , Hodges Amanda 
Published: April 2021

Abstract
Agriculture is the second most important industry in Florida having a market value of over $7.35 billion. In the United States, only 1.3% of the population works in agriculture and the average age of a farmer is 57.5 yr old, which supports a need for youth to pursue careers in agricultural fields. Despite the importance of this industry, there is a growing disconnect between the public and agriculture as demonstrated by low agricultural literacy levels. An outreach program and pre- and postsurveys were used to gain a better understanding of the need for agricultural literacy educational programs in Florida. Outreach curricula were designed on four topics related to agricultural literacy; ‘Plant Biosecurity: Local and Global Perspectives’, ‘Invasive Species that Affect Plants’, ‘Introduction to Entomology’, and ‘Florida Agriculture: Current Issues and Potential Careers’. Over 2 yr, interactive outreach events were held in 80 classrooms around Florida reaching a total of 2,326 students. Based on survey results, the current agricultural literacy levels in Florida are low. The designed outreach program significantly improved student knowledge levels and increased student interest in agricultural careers/fields.
Single response assessment of transplant-ineligible multiple myeloma: a supplementary analysis of JCOG1105 (JCOG1105S1)
Authors: Nakamura Nobuhiko , Maruyama Dai , Machida Ryunosuke , Ichinohe Tatsuo , Takayama Nobuyuki , Ohba Rie , Ohmachi Ken , Imaizumi Yoshitaka , Tokunaga Masahito , Katsuya Hiroo , Yoshida Isao , Sunami Kazutaka , Kurosawa Mitsutoshi , Kubota Nobuko , Morimoto Hiroaki , Kobayashi Miki , Kato Harumi , Kameoka Yoshihiro , Kagami Yoshitoyo , Kizaki Masahiro , Takeuchi Kazuto , Munakata Wataru , Iida Shinsuke , Nagai Hirokazu 
Published: April 2021

Abstract

Background
The International Myeloma Working Group response criteria require two consecutive assessments of paraprotein levels. We conducted an exploratory analysis to evaluate whether a single response assessment could be a substitute for the International Myeloma Working Group criteria using data from JCOG1105, a randomized phase II study on melphalan, prednisolone and bortezomib.

Methods
Of 91 patients with transplant-ineligible newly diagnosed multiple myeloma, 79 patients were included. We calculated the kappa coefficient to evaluate the degree of agreement between the International Myeloma Working Group criteria and the single response assessment.

Results
Based on the International Myeloma Working Group criteria, 11 (13.9%), 20 (25.3%), 36 (45.6%) and 12 (15.2%) patients had stringent complete response/complete response, very good partial response, partial response and stable disease, respectively. Based on the single response assessment, 17 (21.5%), 19 (24.1%), 35 (44.3%) and 8 (10.1%) patients had stringent complete response/complete response, very good partial response, partial response and stable disease, respectively. The kappa coefficient was 0.76 (95% confidence interval, 0.65–0.88), demonstrating good agreement. The single response assessment was not inferior to the International Myeloma Working Group criteria in the median progression-free survival (3.8 and 2.9 years) in stringent complete response/complete response patients, suggesting that the single response assessment was not an overestimation.

Conclusions
The single response assessment could be a substitute for the current International Myeloma Working Group criteria for transplant-ineligible newly diagnosed multiple myeloma.
Predictors of Chronic Opioid Use: A Population-Level Analysis of North Carolina Cancer Survivors Using Multi-Payer Claims
Authors: Check Devon K , Baggett Christopher D , Kim KyungSu , Roberts Andrew W , Roberts Megan C , Robinson Timothy , Oeffinger Kevin C , Dinan Michaela A 
Published: April 2021

Abstract

Background
No population-based studies have examined chronic opioid use among cancer survivors who are diverse with respect to diagnosis, age group, and insurance status.

Methods
We conducted a retrospective cohort study using North Carolina cancer registry data linked with claims from public and private insurance (2006-2016). We included adults with nonmetastatic cancer who had no prior chronic opioid use (n = 38 366). We used modified Poisson regression to assess the adjusted relative risk of chronic opioid use in survivorship (&gt;90-day continuous supply of opioids in the 13-24 months following diagnosis) associated with patient characteristics.

Results
Only 3.0% of cancer survivors in our cohort used opioids chronically in survivorship. Predictors included younger age (adjusted risk ratio [aRR] 50-59 vs 60-69 = 1.23, 95% confidence interval [CI] = 1.05 to 1.43), baseline depression (aRR = 1.22, 95% CI = 1.06 to 1.41) or substance use (aRR = 1.43, 95% CI = 1.15 to 1.78) and Medicaid (aRR vs private = 1.93, 95% CI = 1.56 to 2.40). Survivors who used opioids intermittently (vs not at all) before diagnosis were twice as likely to use opioids chronically in survivorship (aRR = 2.62, 95% CI = 2.28 to 3.02). Those who used opioids chronically (vs intermittently or not at all) during active treatment had a nearly 17-fold increased likelihood of chronic use in survivorship (aRR = 16.65, 95% CI = 14.30 to 19.40).

Conclusions
Younger and low-income survivors, those with baseline depression or substance use, and those who require chronic opioid therapy during treatment are at increased risk for chronic opioid use in survivorship. Our findings point to opportunities to improve assessment of psychosocial histories and to engage patients in shared decision-making around long-term pain management, when chronic opioid therapy is required during treatment.
Risk awareness of black-and-gold howler monkeys living in an urban environment in south-west Paraguay
Authors: Wellian Jake , Smith Rebecca L 
Published: April 2021

AbstractAs urbanisation increases, wild primates are exposed to urban environments which come with a distinct and often novel set of risks. Urban habitats can form a matrix of forest fragments and anthropogenic structures, including buildings, electric cables and roads, which can limit movement and force species to live in hazardous areas. We studied five groups of urban black and gold howler monkey (Alouatta caraya) in Pilar, Paraguay, to investigate whether the monkeys are aware of anthropogenic risks based on their patterns of self-scratching behaviour, an indicator of stress, and how they used the space available to them. Using a Risk Index created for the study, we ranked the level of risk attributed to different zones of their home range, awarding each zone with a hazard score. Using Quantum GIS and kernel density estimation, we determined the relationship between habitat use and hazard score. Using a Spearman’s rank correlation, we found nonsignificant relationships between the hazard score and self-scratching behaviour for four groups, suggesting a lack of awareness. However, there was a significant negative relationship between the hazard score and home range use for four groups, indicating that they spent more time in areas with lower levels of anthropogenic risk.