bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelatihan Perawatan Bayi Baru Lahir
Authors: Wasiah Asyaul , Artamevia Salsabila 
Published: September 2021

Bayi baru lahir (BBL) sangat rentan terhadap infeksi yang disebabkan oleh paparan virus dan kuman selama proses persalinan maupun beberapa saat setelah lahir. Perawatan BBL yang tidak tepat dapat menimbulkan masalah kesehatan pada bayi sampai kematian. Kesalahan tersebut dikarenakan kurangnya pengetahuan dan kesiapan ibu dalam perawatan BBL. Hasil wawancara terhadap 3 ibu nifas diketahui bahwa 2 orang (66,67%) belum mengetahui cara merawat bayinya yang benar. Perawatan BBL yang dimaksud antara lain perawatan tali pusat, memandikan bayi, memberi ASI dan mengganti popok bayi.
Untuk itu pengabdian ini bertujuan untuk meningkatkan pengetahuan, sikap dan perilaku ibu dalam melakukan perawatan Bayi baru lahir untuk mewujudkan tumbuh kembang Balita yang optimal.
Peserta pelatihan adalah kader posyandu dan ibu-ibu yang mempunyai anak usia antara 0-2 tahun. Total peserta pelatihan sebanyak 25 orang . Monitoring dan evaluasi oleh bidan pelaksana terhadap kader dalam pemantauan perawatan bayi baru ahir. Rangkaian kegiatan ini dilakukan selama 2 hari.
Berdasarkan pengabdian selama 2 hari didapatkan hasil sebagai berikut dari 25 responden diketahui sebagian besar mempunyai pengetahuan cukup, disusul dengan pengetahuan baik, dan paling rendah dengan pengetahuan kurang dalam hal pemberian ASI Eksklusif, perawatan tali pusat, memandikan bayi dan mengganti popok.
Kegiatan ini mencapai hasil yakni terbentuknya kelompok kader perawatan bayi baru lahir ”di Desa Sidomuki, Kecamatan Kembangbahu, Kabupaten Lamongan. Tersedianya sarana dan prasarana penunjang kegiatan seperti buku panduan,alat-alat dan bahan perawatan bayi baru lahir.
Optimalisasi Pemberdayaan Masyarakat dalam Peningkatan Kualitas Hidup Lansia melalui Penerapan PHBS selama Pandemi Covid 19 di Belitang
Authors: Fauziandari Erma Nur , Wulandari Amri 
Published: September 2021

Covid-19 merupakan penyakit yang disebabkan Novel Coronavirus (2019-nCoV), atau yang kini dinamakan SARS-CoV-2 yang merupakan virus jenis baru dan belum pernah diidentifikasi sebelumnya pada manusia. Kelompok lanjut usia (lansia) adalah salah satu kelompok rentan yang memiliki morbiditas dan mortalitas tinggi dalam pandemi Covid-19. Lansia juga merupakan kelompok penduduk yang sangat membutuhkan akses terhadap layanan kesehatan karena sebagian besar memiliki penyakit kronik/degeneratif.
Tresnayanti (2015) menyatakan Perilaku Hidup Bersih dan Sehat (PHBS) di rumah tangga merupakan upaya memberdayakan anggota rumah tangga agar tahu, mau dan mampu melaksanakan PHBS serta berperan aktif dalam gerakan kesehatan di masyarakat. Tujuan Pengabdian masyarakat ini adalah mengoptimalkan Pemberdayaan Masyarakat Dalam Peningkatan Kualitas Hidup Lansia Melalui Penerapan PHBS selama masa pandemi Covid-19. Metode pelaksanaan adalah dengan ceramah dan Praktek/simulasi. Setelah dilakukan kegiatan ceramah dan simulasi kegiatan senam lansia didapatkan bahwa peserta memahami cara melakukan PHBS dan mulai menerapkan aktivitas fisik dalam upaya meningkatkan kesehatan.
Peningkatan Kesehatan Masyarakat Teluk Batang secara Mandiri melalui pembuatan Handsanitizer dan Desinfektan berbasis Eco-Enzyme dari Limbah Sayuran dan Buah
Authors: Safitri Ikha , Yuliono Agus , Sofiana Mega Sari Juane , Helena Shifa , Kushadiwijayanto Arie Antasari , Warsidah Warsidah 
Published: September 2021

Kesehatan adalah salah satu berkah yang sangat berharga dalam kehidupan. Kondisi pandemi Covid-19 telah melahirkan budaya 3M dalam kehidupan sehari-hari, yaitu memakai masker, menjaga jarak dan mencuci tangan. Mencuci tangan menggunakan handsanitizer merupakan cara yang praktis untuk membunuh mikroorganisme. Namun, handsanitizer yang tersedia di pasaran memiliki variasi bahan baku yang mengandung Alkohol 96% dan peroksida. Pemakaian yang sering dan dalam jangka waktu yang lama dapat memberikan efek samping iritasi pada kulit tangan. Selain itu, upaya lain untuk menjaga kebersihan lingkungan dapat dilakukan dengan menggunakan larutan desinfektan. Larutan ini dapat membebaskan lantai, dinding rumah, peralatan rumah tangga, dan udara sekitar dari mikroorganisme. Namun, desinfektan umumnya mengandung komponen kimia yang sangat korosif. Oleh karena itu, kondisi ini mendorong pencarian sumber bahan ramah lingkungan. Pelatihan ini bertujuan untuk meningkatkan kesehatan masyarakat Teluk Batang secara mandiri melalui pembuatan handsanitizer dan desinfektan berbasis eco-enzyme dari limbah sayuran dan buah. Eco-enzyme dibuat dari 5kg sampah campuran sayur dan buah yang difermentasi selama 3 bulan, dihasilkan cairan enzim sebanyak 9 kg dan ampas fermentasi sebanyak 6 kg. Kemudian, handsanitizer diproduksi menggunakan rasio 10% : 40% dengan mencampur 100 mL eco-enzyme dan 400 mL air bersih. Sedangkan larutan desinfektan dibuat menggunakan rasio 50% : 50% dengan mencampur 250 mL eco-enzyme dan 250 mL air bersih. Produk yang dihasilkan kemudian diberi label dan dapat digunakan langsung oleh peserta pelatihan.
Laboratory Investigations of Extrasensory Identification of Concealed 5-Character Codes by a Presumably Gifted Teenager
Authors: Shen Dong , Shen Run-Sheng , Li Gang , Piao Daqing 
Published: September 2021

This report summarizes three “eyeless sight” experiments and reaffirms the authenticity of the phenomenon of clairvoyance (extrasensory perception). On 2014 and 2015, a total of 37 trials were conducted. Each trial involved a computer printing a 5-character permutation (e.g. 37K9J) in bold type on a piece of paper which was then folded to conceal the text. The “eyeless sight” practitioner was a girl who had previously been trained to develop her “eyeless sight” ability. The practitioner held the folded specimen between her thumb and forefinger. After adjusting to a specific state of consciousness (Second Consciousness State, SCS), the practitioner visualized a “ Third Eye Screen” (TES) in front of her forehead. The five-character string was then automatically perceived on the TES by the practitioner. After the perceived image stabilized, the permutation was reported to the researcher and transcribed. The whole experimental process was recorded on video cameras. The mean chance expectation for the correct hit rate of a five-character permutation is p≈10-70 and is vanishingly small. The importance of the SCS and the image generation process on the TES is discussed.
Key words: Eyeless sight - Extrasensory perception (ESP) - Psychokinesis (PK) - Third Eye Screen (TES) - First Consciousness State (FCS) - Second Consciousness State (SCS) - recognition of characters with fingers (Clairvoyance)
Adult-onset presentation of cervicothoracic split cord malformation: illustrative case
Authors: Soh Huei Ti 
Published: September 2021

BACKGROUND
A 60-year-old female presented with a 6-month history of progressive lower limb pain, weakness, and declining mobility. She was initially diagnosed as having possible hip osteoarthritis or ligamental knee injury. She was eventually seen by a neurologist, who admitted her to a tertiary hospital with new-onset upper motor neuron signs and urinary incontinence. Magnetic resonance imaging of the whole spine revealed evidence of C7–T2 type 1 split cord malformation (SCM) necessitating urgent spinal surgery. She had an excellent outcome with intensive rehabilitation and returned to her premorbid level of function and mobility.

OBSERVATIONS
The patient presented with nonspecific symptoms, which led to multiple referrals and a significant delay in her diagnosis.

LESSONS
Clinicians should be aware of the importance of a detailed history with thorough neurological and spinal examinations.
Computational hemodynamic analysis of the offending vertebral artery at the site of neurovascular contact in a case of hemifacial spasm associated with subclavian steal syndrome: illustrative case
Authors: Tominaga Keita , Endo Hidenori , Sugiyama Shin-ichiro , Osawa Shin-ichiro , Niizuma Kuniyasu , Tominaga Teiji 
Published: September 2021

BACKGROUND
Hemifacial spasm (HFS) is caused by neurovascular contact along the facial nerve’s root exit zone (REZ). The authors report a rare HFS case that was associated with ipsilateral subclavian steal syndrome (SSS).

OBSERVATIONS
A 42-year-old man with right-sided aortic arch presented with progressing left HFS, which was associated with ipsilateral SSS due to severe stenosis of the left brachiocephalic trunk. Magnetic resonance imaging showed contact between the left REZ and vertebral artery (VA), which had shifted to the left. The authors speculated that the severe stenosis at the left brachiocephalic trunk resulted in the left VA’s deviation, which was the underlying cause of the HFS. The authors performed percutaneous angioplasty (PTA) to dilate the left brachiocephalic trunk. Ischemic symptoms of the left arm improved after PTA, but the HFS remained unchanged. A computational fluid dynamics study showed that the high wall shear stress (WSS) around the site of neurovascular contact decreased after PTA. In contrast, pressure at the point of neurovascular contact increased after PTA.

LESSONS
SSS is rarely associated with HFS. Endovascular treatment for SSS reduced WSS of the neurovascular contact but increased theoretical pressure of the neurovascular contact. Physical release of the neurovascular contact is the best treatment option for HFS.
Physical development and individual metabolic parameters in various forms of congenital epidermolysis bullosa depending on supplementation treatment
Authors: Pronina I. Yu. , Murashkin N. N. , Makarova S. G. , Fisenko A. P. , Semikina E. L. , Epishev R. V. , Leonova M A. 
Published: September 2021

Congenital epidermolysis bullosa (CEB) is a group of rare genetic diseases of varying severity, which are characterized with the formation of blisters on the skin and/or mucous membranes with minor trauma. In this case, the clinical course of the disease in some cases is aggravated by the development of malnutrition, which further worsens the quality of life of patients.Aim of the study. To assess the physical development and laboratory findings of nutritional status in children with simple (SCEB) and dystrophic forms of CEB (DCEB).Methods and materials. The study included children with SCEB and DCEB at the age of 8 months to 18 years old, treated at the National Medical Research Centre of Children's Health (Moscow, Russia) from January 2018 to January 2019. Anthropometric parameters were assessed in all patients, and a biochemical blood test was performed for total calcium, phosphorus, albumin, and magnesium. Data are presented using the median (Me) and quartiles of 25 % and 75 % [Q25; Q75], as well as the mean (M) and 95 % confidence interval (95 % CI) for variables with a normal distribution.Results. A total of 87 children were included in the study, 70 with DCEB and 17 with SCEB. There were no differences in sex and age between the groups. According to the results of the study, all anthropometric parameters (WAZ, HAZ and BAZ) in children with DCEB were statistically significantly lower (p < 0.001) than in children with SCEB. Although in both forms of CEB the averaged values of WAZ, HAZ and BAZ turned out to be within the normal range, in children with DCEB, a decrease in HAZ less than -2 was noted in 22 children (31%). Moderate protein-energy malnutrition (-3 < BAZ < -2) was detected in 29 patients (41 %), while 20 of them (29%) were diagnosed with severe protein-energy malnutrition (BAZ < -3). Biochemical parameters were within the reference values, however, the levels of albumin and total calcium were statistically significantly reduced in children with DCEB compared with SCEB children (p < 0.001 and p = 0.005, respectively). Hypoalbuminemia was observed in 64 %, and hypocalcemia in 9 % of DCEB children.Conclusion. All anthropometric values in children with DCEB were lower than in children with SCEB. The study of albumin and total calcium level in the blood of children with DCEB can reveal preclinical forms of malnutrition.
Bone Regeneration in Load-Bearing Segmental Defects, Guided by Biomorphic, Hierarchically Structured Apatitic Scaffold
Authors: Kon Elizaveta , Salamanna Francesca , Filardo Giuseppe , Di Matteo Berardo , Shabshin Nogah , Shani Jonathan , Fini Milena , Perdisa Francesco , Parrilli Annapaola , Sprio Simone , Ruffini Andrea , Marcacci Maurilio , Tampieri Anna 
Published: September 2021

The regeneration of load-bearing segmental bone defects remains a significant clinical problem in orthopedics, mainly due to the lack of scaffolds with composition and 3D porous structure effective in guiding and sustaining new bone formation and vascularization in large bone defects. In the present study, biomorphic calcium phosphate bone scaffolds (GreenBone™) featuring osteon-mimicking, hierarchically organized, 3D porous structure and lamellar nano-architecture were implanted in a critical cortical defect in sheep and compared with allograft. Two different types of scaffolds were tested: one made of ion-doped hydroxyapatite/β-tricalcium-phosphate (GB-1) and other made of undoped hydroxyapatite only (GB-2). X-ray diffraction patterns of GB-1 and GB-2 confirmed that both scaffolds were made of hydroxyapatite, with a minor amount of β-TCP in GB-1. The chemical composition analysis, obtained by ICP-OES spectrometer, highlighted the carbonation extent and the presence of small amounts of Mg and Sr as doping ions in GB-1. SEM micrographs showed the channel-like wide open porosity of the biomorphic scaffolds and the typical architecture of internal channel walls, characterized by a cell structure mimicking the natural parenchyma of the rattan wood used as a template for the scaffold fabrication. Both GB-1 and GB-2 scaffolds show very similar porosity extent and 3D organization, as also revealed by mercury intrusion porosimetry. Comparing the two scaffolds, GB-1 showed slightly higher fracture strength, as well as improved stability at the stress plateau. In comparison to allograft, at the follow-up time of 6 months, both GB-1 and GB-2 scaffolds showed higher new bone formation and quality of regenerated bone (trabecular thickness, number, and separation). In addition, higher osteoid surface (OS/BS), osteoid thickness (OS.Th), osteoblast surface (Ob.S/BS), vessels/microvessels numbers, as well as substantial osteoclast-mediated implant resorption were observed. The highest values in OS.Th and Ob. S/BS parameters were found in GB-1 scaffold. Finally, Bone Mineralization Index of new bone within scaffolds, as determined by micro-indentation, showed a significantly higher microhardness for GB-1 scaffold in comparison to GB-2. These findings suggested that the biomorphic calcium phosphate scaffolds were able to promote regeneration of load-bearing segmental bone defects in a clinically relevant scenario, which still represents one of the greatest challenges in orthopedics nowadays.
Isotope-Dilution Gas Chromatography-Mass Spectrometry Method for the Selective Detection of Nicotine and Menthol in E-Cigarette, or Vaping, Product Liquids and Aerosols
Authors: Pérez José J. , Watson Clifford H. , Blount Benjamin C. , Valentín-Blasini Liza 
Published: September 2021

We developed a quantitative method for analyzing nicotine and menthol in e-cigarette, or vaping, products (EVPs). These products may adversely impact health through inhalational exposure to addictive and harmful chemicals. The presence of unknown substances in do-it-yourself e-liquids, counterfeits, or unregulated products may increase exposure to harmful chemicals, as underscored by the 2019 EVP use-associated lung injury (EVALI) outbreak. To minimize these risks, it is important to accurately quantify nicotine and menthol in e-liquids and aerosol emissions to evaluate EVP authenticity, verify product label accuracy, and identify potentially hazardous products. We developed a simple, versatile, high-throughput method using isotope-dilution gas chromatography-mass spectrometry for quantifying nicotine and menthol concentrations in both e-liquid contents and machine-generated aerosol emissions of EVPs. Rigorous validation has demonstrated that the method is specific, precise (CV&lt;2.71%), accurate (percent error ≤7.0%), and robust. Linear calibration ranges from 0.01 to 1.00 mg/ml for both analytes was achieved, corresponding to expected analyte levels in e-liquids and machine-generated EVP aerosols. Limits of detection (LODs) in the final 10-ml sample extract were 0.4 μg/ml for nicotine and 0.2 μg/ml for menthol. The method was used to analyze aerosol emissions of 141 EVPs associated with the 2019 EVALI outbreak; detectable levels of nicotine (2.19–59.5 mg/g of aerosol) and menthol (1.09–10.69 mg/g of aerosol) were observed in 28 and 11%, respectively, of the samples analyzed. Nicotine was not detected in any of the tetrahydrocannabinol (THC), cannabidiol (CBD), or oil-based products, while menthol (2.95 mg/g of aerosol) was only detected in one of these products (THC-labeled). The analytical method can be used to quantify nicotine and menthol concentrations in the e-liquids and aerosols from a range of EVPs, and these findings highlight a difference between e-cigarette and other vaping products.
Cardiovascular Toxicity of Carfilzomib: The Real-World Evidence Based on the Adverse Event Reporting System Database of the FDA, the United States
Authors: Zhai Yinghong , Ye Xiaofei , Hu Fangyuan , Xu Jinfang , Guo Xiaojing , Cao Yang , Lin Zhen , Zhou Xiang , Guo Zhijian , He Jia 
Published: September 2021

Background: Carfilzomib, an effective proteasome inhibitor agent for the therapy of relapsed and refractory multiple myeloma, has been related to a significant number of cardiovascular events. However, patterns of cardiovascular complications associated with this agent remain poorly characterized in real-world settings.Objective: To gain further insight into the frequency, spectrum, clinical features, timing, and outcomes of carfilzomib-related cardiovascular toxicities.Methods: This disproportionality (case/non-case) study was conducted leveraging records from FAERS database from 2014 to 2019. Cardiovascular events were defined and broadly categorized eight entities using narrow version of the Standardized MedDRA Queries (SMQs). Reporting odds ratios (ROR) and information component (IC) were calculated to measure disproportionality. Additionally, statistical shrinkage was applied to reduce false-positive signals.Results: The final number of records involved was 28,479,963, with 3,370 records submitted for carfilzomib related cardiovascular events. Significant disproportionality association between carfilzomib administration and cardiovascular events was captured (IC025/ROR025 = 0.85/1.95) when exploring in the entire database. Upon further analysis, all eight broad categories of cardiovascular toxicities were disproportionately associated with carfilzomib with varying frequencies, time-to-onset, and severities. Cardiomyopathy-related complications (N = 1,301, 38.61%), embolic and thrombotic events (N = 821, 24.36%), and cardiac failure (N = 765, 22.70%) largely comprised the reported problems. Notably, the strongest signal was detected for cardiac failure (IC025/ROR025 = 1.33/2.59), followed by pulmonary hypertension (IC025/ROR025 = 1.19/2.34). Median onset time of cardiovascular events was 41days (Q1-Q3: 9-114 days), with the shortest median time being 16 days (Q1–Q3: 4–85 days) for ischemic heart disease, with the longest time being 68 days (Q1–Q3: 21–139 days) for embolic and thrombotic events. Torsade de pointes/QT prolongation was identified as a new complication (IC025/ROR025 = 0.33/1.29) and was particularly noteworthy for highest death proportion (44.11%).Conclusions: Treatment with carfilzomib can lead to severe and versatile cardiovascular events. Early and intensive monitoring is important, particularly in the first 3 months after carfilzomib initiation. Maximizing the benefit while reducing potential cardiovascular harms of carfilzomib should become a priority.
Trace Element (Fe, Co, Ni and Cu) Dynamics Across the Salinity Gradient in Arctic and Antarctic Glacier Fjords
Authors: Krause Jana , Hopwood Mark J. , Höfer Juan , Krisch Stephan , Achterberg Eric P. , Alarcón Emilio , Carroll Dustin , González Humberto E. , Juul-Pedersen Thomas , Liu Te , Lodeiro Pablo , Meire Lorenz , Rosing Minik T. 
Published: September 2021

Around the Greenlandic and Antarctic coastlines, sediment plumes associated with glaciers are significant sources of lithogenic material to the ocean. These plumes contain elevated concentrations of a range of trace metals, especially in particle bound phases, but it is not clear how these particles affect dissolved (&lt;0.2 µm) metal distributions in the ocean. Here we show, using transects in 8 glacier fjords, trends in the distribution of dissolved iron, cobalt, nickel and copper (dFe, dCo, dNi, dCu). Following rapid dFe loss close to glacier outflows, dFe concentrations in particular showed strong similarities between different fjords. Similar dFe concentrations were also observed between seasons/years when Nuup Kangerlua (SW Greenland) was revisited in spring, mid- and late-summer. Dissolved Cu, dCo and dNi concentrations were more variable and showed different gradients with salinity depending on the fjord, season and year. The lack of consistent trends for dCu and dNi largely reflects less pronounced differences contrasting the concentration of inflowing shelf waters with fresher glacially-modified waters. Particles also made only small contributions to total dissolvable Cu (dCu constituted 83 ± 28% of total dissolvable Cu) and Ni (dNi constituted 86 ± 28% of total dissolvable Ni) within glacier plumes. For comparison, dFe was a lower fraction of total dissolvable Fe; 3.5 ± 4.8%. High concentrations of total dissolvable Fe in some inner-fjord environments, up to 77 µM in Ameralik (SW Greenland), may drive enhanced removal of scavenged type elements, such as Co. Further variability may have been driven by local bedrock mineralogy, which could explain high concentrations of dNi (25–29 nM) and dCo (6–7 nM) in one coastal region of west Greenland (Kangaatsiaq). Our results suggest that dissolved trace element distributions in glacier fjords are influenced by a range of factors including: freshwater concentrations, local geology, drawdown by scavenging and primary production, saline inflow, and sediment dynamics. Considering the lack of apparent seasonality in dFe concentrations, we suggest that fluxes of some trace elements may scale proportionately to fjord overturning rather than directly to freshwater discharge flux.
Histopathologic Features of Antibody Mediated Rejection: The Banff Classification and Beyond
Authors: Cornell Lynn D. 
Published: September 2021

Antibody mediated rejection (ABMR) in the kidney can show a wide range of clinical presentations and histopathologic patterns. The Banff 2019 classification currently recognizes four diagnostic categories: 1. Active ABMR, 2. Chronic active ABMR, 3. Chronic (inactive) ABMR, and 4. C4d staining without evidence of rejection. This categorization is limited in that it does not adequately represent the spectrum of antibody associated injury in allograft, it is based on biopsy findings without incorporating clinical features (e.g., time post-transplant, de novo versus preformed DSA, protocol versus indication biopsy, complement inhibitor drugs), the scoring is not adequately reproducible, and the terminology is confusing. These limitations are particularly relevant in patients undergoing desensitization or positive crossmatch kidney transplantation. In this article, I discuss Banff criteria for these ABMR categories, with a focus on patients with pre-transplant DSA, and offer a framework for considering the continuum of allograft injury associated with donor specific antibody in these patients.