bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiological and Pharmacological Roles of PTH and PTHrP in Bone Using Their Shared Receptor, PTH1R
Authors: Martin T John , Sims Natalie A , Seeman Ego 
Published: February 2021

Abstract
Parathyroid hormone (PTH) and the paracrine factor, PTH-related protein (PTHrP), have preserved in evolution sufficient identities in their amino-terminal domains to share equivalent actions upon a common G protein-coupled receptor, PTH1R, that predominantly uses the cyclic adenosine monophosphate-protein kinase A signaling pathway. Such a relationship between a hormone and local factor poses questions about how their common receptor mediates pharmacological and physiological actions of the two. Mouse genetic studies show that PTHrP is essential for endochondral bone lengthening in the fetus and is essential for bone remodeling. In contrast, the main postnatal function of PTH is hormonal control of calcium homeostasis, with no evidence that PTHrP contributes. Pharmacologically, amino-terminal PTH and PTHrP peptides (teriparatide and abaloparatide) promote bone formation when administered by intermittent (daily) injection. This anabolic effect is remodeling-based with a lesser contribution from modeling. The apparent lesser potency of PTHrP than PTH peptides as skeletal anabolic agents could be explained by lesser bioavailability to PTH1R. By contrast, prolongation of PTH1R stimulation by excessive dosing or infusion, converts the response to a predominantly resorptive one by stimulating osteoclast formation. Physiologically, locally generated PTHrP is better equipped than the circulating hormone to regulate bone remodeling, which occurs asynchronously at widely distributed sites throughout the skeleton where it is needed to replace old or damaged bone. While it remains possible that PTH, circulating within a narrow concentration range, could contribute in some way to remodeling and modeling, its main physiological role is in regulating calcium homeostasis.
Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time?
Authors: Ho Ken , Fleseriu Maria , Kaiser Ursula , Salvatori Roberto , Brue Thierry , Lopes M Beatriz , Kunz Pamela , Molitch Mark , Camper Sally A , Gadelha Mônica , Syro Luis V , Laws Edward , Reincke Martin , Nishioka Hiroshi , Grossman Ashley , Barkan Ariel , Casanueva Felipe , Wass John , Mamelak Adam , Katznelson Laurence , van der Lely Aart J , Radovick Sally , Bidlingmaier Martin , Boguszewski Margaret , Bollerslev Jens , Hoffman Andrew R , Oyesiku Nelson , Raverot Gerald , Ben-Shlomo Anat , Fowkes Rob , Shimon Ilan , Fukuoka Hidenori , Pereira Alberto M , Greenman Yona , Heaney Anthony P , Gurnell Mark , Johannsson Gudmundur , Osamura Robert Y , Buchfelder Michael , Zatelli Maria Chiara , Korbonits Marta , Chanson Philippe , Biermasz Nienke , Clemmons David R , Karavitaki Niki , Bronstein Marcello D , Trainer Peter , Melmed Shlomo 
Published: February 2021

Abstract
The WHO Classification of Endocrine Tumours designates pituitary neoplasms as adenomas. A proposed nomenclature change to pituitary neuroendocrine tumors (PitNETs) has been met with concern by some stakeholder groups. The Pituitary Society coordinated the Pituitary Neoplasm Nomenclature (PANOMEN) workshop to address the topic. Experts in pituitary developmental biology, pathology, neurosurgery, endocrinology, and oncology, including representatives nominated by the Endocrine Society, European Society of Endocrinology, European Neuroendocrine Association, Growth Hormone Research Society, and International Society of Pituitary Surgeons. Clinical epidemiology, disease phenotype, management, and prognosis of pituitary adenomas differ from that of most NETs. The vast majority of pituitary adenomas are benign and do not adversely impact life expectancy. A nomenclature change to PitNET does not address the main challenge of prognostic prediction, assigns an uncertain malignancy designation to benign pituitary adenomas, and may adversely affect patients. Due to pandemic restrictions, the workshop was conducted virtually, with audiovisual lectures and written précis on each topic provided to all participants. Feedback was collated and summarized by Content Chairs and discussed during a virtual writing meeting moderated by Session Chairs, which yielded an evidence-based draft document sent to all participants for review and approval. There is not yet a case for adopting the PitNET nomenclature. The PANOMEN Workshop recommends that the term adenoma be retained and that the topic be revisited as new evidence on pituitary neoplasm biology emerges.
Analyzing the Effect of Time in Migration Measurement Using Georeferenced Digital Trace Data
Authors: Fiorio Lee , Zagheni Emilio , Abel Guy , Hill Johnathan , Pestre Gabriel , Letouzé Emmanuel , Cai Jixuan 
Published: February 2021

Abstract
Georeferenced digital trace data offer unprecedented flexibility in migration estimation. Because of their high temporal granularity, many migration estimates can be generated from the same data set by changing the definition parameters. Yet despite the growing application of digital trace data to migration research, strategies for taking advantage of their temporal granularity remain largely underdeveloped. In this paper, we provide a general framework for converting digital trace data into estimates of migration transitions and for systematically analyzing their variation along a quasi-continuous time scale, analogous to a survival function. From migration theory, we develop two simple hypotheses regarding how we expect our estimated migration transition functions to behave. We then test our hypotheses on simulated data and empirical data from three platforms in two internal migration contexts: geotagged Tweets and Gowalla check-ins in the United States, and cell-phone call detail records in Senegal. Our results demonstrate the need for evaluating the internal consistency of migration estimates derived from digital trace data before using them in substantive research. At the same time, however, common patterns across our three empirical data sets point to an emergent research agenda using digital trace data to study the specific functional relationship between estimates of migration and time and how this relationship varies by geography and population characteristics.
Trio family proteins as regulators of cell migration and morphogenesis in development and disease – mechanisms and cellular contexts
Authors: Bircher Josie E. , Koleske Anthony J. 
Published: February 2021

ABSTRACT
The well-studied members of the Trio family of proteins are Trio and kalirin in vertebrates, UNC-73 in Caenorhabditis elegans and Trio in Drosophila. Trio proteins are key regulators of cell morphogenesis and migration, tissue organization, and secretion and protein trafficking in many biological contexts. Recent discoveries have linked Trio and kalirin to human disease, including neurological disorders and cancer. The genes for Trio family proteins encode a series of large multidomain proteins with up to three catalytic activities and multiple scaffolding and protein–protein interaction domains. As such, Trio family proteins engage a wide array of cell surface receptors, substrates and interaction partners to coordinate changes in cytoskeletal regulatory and protein trafficking pathways. We provide a comprehensive review of the specific mechanisms by which Trio family proteins carry out their functions in cells, highlight the biological and cellular contexts in which they occur, and relate how alterations in these functions contribute to human disease.
Cardiorespiratory adjustments to chronic environmental warming improve hypoxia tolerance in European perch (Perca fluviatilis)
Authors: Ekström Andreas , Sundell Erika , Morgenroth Daniel , McArley Tristan , Gårdmark Anna , Huss Magnus , Sandblom Erik 
Published: February 2021

ABSTRACT
Aquatic hypoxia will become increasingly prevalent in the future as a result of eutrophication combined with climate warming. While short-term warming typically constrains fish hypoxia tolerance, many fishes cope with warming by adjusting physiological traits through thermal acclimation. Yet, little is known about how such adjustments affect tolerance to hypoxia. We examined European perch (Perca fluviatilis) from the Biotest enclosure (23°C, Biotest population), a unique ∼1 km2 ecosystem artificially warmed by cooling water from a nuclear power plant, and an adjacent reference site (16–18°C, reference population). Specifically, we evaluated how acute and chronic warming affect routine oxygen consumption rate (ṀO2,routine) and cardiovascular performance in acute hypoxia, alongside assessment of the thermal acclimation of the aerobic contribution to hypoxia tolerance (critical O2 tension for ṀO2,routine: Pcrit) and absolute hypoxia tolerance (O2 tension at loss of equilibrium; PLOE). Chronic adjustments (possibly across lifetime or generations) alleviated energetic costs of warming in Biotest perch by depressing ṀO2,routine and cardiac output, and by increasing blood O2 carrying capacity relative to reference perch acutely warmed to 23°C. These adjustments were associated with improved maintenance of cardiovascular function and ṀO2,routine in hypoxia (i.e. reduced Pcrit). However, while Pcrit was only partially thermally compensated in Biotest perch, they had superior absolute hypoxia tolerance (i.e. lowest PLOE) relative to reference perch irrespective of temperature. We show that European perch can thermally adjust physiological traits to safeguard and even improve hypoxia tolerance during chronic environmental warming. This points to cautious optimism that eurythermal fish species may be resilient to the imposition of impaired hypoxia tolerance with climate warming.
Supplemental oxygen in Queen Elizabeth Central Hospital Malawi: a prospective cohort study of patients admitted to medical wards
Authors: Thomson Helen , Mlaviwa Maness , Rylance Jamie , Jones Hannah , Reuben Ammoah , Stolbrink Marie 
Published: February 2021

Background: Oxygen is designated an essential drug by the World Health Organisation, and reduces mortality in hypoxic patients. In low-resource settings the provision of oxygen seldom meets its demand. This study describes the predictors and observed time-course of hypoxaemia in order to inform needs assessments for oxygen in hospitals in low and middle income countries. Methods: A prospective cohort study of adults with hypoxaemia admitted to medical wards of a teaching hospital in Malawi between January and March 2020. Vital signs and oxygen therapy were recorded daily. We analysed outcomes (death, discharge from hospital or ongoing inpatient care at 14 days after admission) using Kaplan-Meier and Cox regression time-to-event analysis. Results: 33 patients were recruited with median age 45 years (IQR 33-61), and 13 (39%) female. Median pre-treatment oxygen saturations were 84% (IQR 76-87%). Oxygen delivery devices were often shared with other patients (n=10, 33%) and the flow rate was often unknown (n=14, 47%), mostly because of broken equipment (n=8, 57%). Median duration of oxygen therapy was 3 days (IQR 1-7). Death occurred in 16 (49%). Hazard ratios for short oxygen therapy were reduced in patients who had a chest radiograph performed (HR 0.08, 95% CI 0.02–0.30), in ex-smokers (HR 0.01, 95% CI 0.00-0.22) and in never smokers (HR 0.03, 95% CI 0.00 – 0.78). Conclusions: Delivering oxygen therapy in lower-middle income countries is challenging; broken equipment and shared delivery devices prevented titration of flow rates. Patients were relatively young and at a high risk of death. Patients with a chest radiograph received oxygen for longer than those without. Knowledge of oxygen therapy durations will allow careful assessment of the oxygen supply need at the hospital level.
Medium and large-sized mammals in montane habitats of Oaxaca, México
Authors: Ramírez-Bautista Arturo , Lavariega Mario C. 
Published: February 2021

Los inventarios locales constituyen la base para entender la distribución de las especies y los procesos ecológicos e históricos subyacentes. Esta información, en asociación con la documentación de los motivos de caza de las especies, es necesaria para el diseño de estrategias de conservación. Este estudio provee datos nuevos de las especies de mamíferos medianos y grandes del Cerro Piedra Larga (CPL), un macizo montañoso interior en Oaxaca, México. Obtuvimos datos de observaciones directas en transectos, búsqueda de rastros y fototrampeo en bosque tropical caducifolio, bosque seco de pino-encino y en bosque de pino-encino. Registramos los motivos de caza de los mamíferos por la gente local a través de entrevistas informales. Cuantificamos el número de especies e identificamos aquellas que están en alguna categoría de riesgo para su conservación. Reportamos la presencia de 26 especies de mamíferos medianos y grandes en el CPL. Siete especies están en alguna categoría de riesgo. Los habitantes reconocieron la presencia de 23 especies, de las cuales 14 son cazadas para prevenir daños sobre animales domésticos y cultivos. Cinco especies son cazadas por su carne. Las observaciones directas, el fototrampeo y las entrevistas fueron métodos complementarios que ayudaron a tener una mejor lista de las especies. Siete especies constituyen los primeros registros para toda la subprovincia. El registro de Cuniculus paca representa una extensión de su distribución hacia el centro-sur de Oaxaca. Considerando a los mamíferos pequeños, los voladores y los medianos y grandes, el CPL tiene el 24.9 % del total de mamíferos terrestres registrados en Oaxaca. Este estudio destaca la importancia de este macizo montañoso por su diversidad de mamíferos, la cual es amenazada por agricultura de roza-tumba y quema, y actividades de desarrollo carretero.
Experimental demonstration of 1011 temporal contrast in pure nanosecond optical parametric chirped pulse amplifiers
Authors: Sun Meizhi , Xie Xinglong , Zhu Jianqiang , Zhang Xiaoqi , Zhang Yan , Zhu Ping , Guo Ailin , Kang Jun , Zhu Haidong , Yang Qingwei , Liang Xiao 
Published: February 2021

The temporal contrast of ultrashort and ultraintense laser pulses can significantly influence the laser–plasma interactions. As the optical parametric chirped pulse amplification (OPCPA) has been widely adopted in these laser facilities, the inherent optical parametric fluorescence, exhibiting a pedestal in the time window of the pump pulse, has become a significant problem. In this paper, we investigated experimentally its influence on the contrast of the compressed pulses at 808 nm using a multistage OPCPA amplifier. Compared to the highest value of

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ever reported in the literature for such a type of regime, by adjusting the pump energy allocation between OPCPA stages and controlling the gain of small signal regime, we for the first time, to the best of our knowledge, realized a

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temporal contrast in a pure nanosecond OPCPA design at a gain exceeding

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, without adopting any other noise cleaning methods, such as picosecond OPCPA, cross-polarized wave generation, etc. This indicates that the OPCPA has a very significant potential for contrast improvement and to become a candidate for the future high-energy amplifiers in ultrashort high-power laser facilities.
Insomnia symptoms and biomarkers of monocyte activation, systemic inflammation, and coagulation in HIV: Veterans Aging Cohort Study
Authors: Polanka Brittanny M. , Kundu Suman , So-Armah Kaku A. , Freiberg Matthew S. , Gupta Samir K. , Zapolski Tamika C. B. , Hirsh Adam T. , Bedimo Roger J. , Budoff Matthew J. , Butt Adeel A. , Chang Chung-Chou H. , Gottlieb Stephen S. , Marconi Vincent C. , Womack Julie A. , Stewart Jesse C. 
Published: February 2021

BackgroundInsomnia may be a risk factor for cardiovascular disease in HIV (HIV-CVD); however, mechanisms have yet to be elucidated.MethodsWe examined cross-sectional associations of insomnia symptoms with biological mechanisms of HIV-CVD (immune activation, systemic inflammation, and coagulation) among 1,542 people with HIV from the Veterans Aging Cohort Study (VACS) Biomarker Cohort. Past-month insomnia symptoms were assessed by the item, “Difficulty falling or staying asleep?,” with the following response options: “I do not have this symptom” or “I have this symptom and…” “it doesn’t bother me,” “it bothers me a little,” “it bothers me,” “it bothers me a lot.” Circulating levels of the monocyte activation marker soluble CD14 (sCD14), inflammatory marker interleukin-6 (IL-6), and coagulation marker D-dimer were determined from blood specimens. Demographic- and fully-adjusted (CVD risk factors, potential confounders, HIV-related factors) regression models were constructed, with log-transformed biomarker variables as the outcomes. We present the exponentiated regression coefficient (exp[b]) and its 95% confidence interval (CI).ResultsWe observed no significant associations between insomnia symptoms and sCD14 or IL-6. For D-dimer, veterans in the “Bothers a Lot” group had, on average, 17% higher D-dimer than veterans in the “No Difficulty Falling or Staying Asleep” group in the demographic-adjusted model (exp[b] = 1.17, 95%CI= 1.01–1.37,p= .04). This association was nonsignificant in the fully-adjusted model (exp[b] = 1.09, 95%CI= 0.94–1.26,p= .27).ConclusionWe observed little evidence of relationships between insomnia symptoms and markers of biological mechanisms of HIV-CVD. Other mechanisms may be responsible for the insomnia-CVD relationship in HIV; however, future studies with comprehensive assessments of insomnia symptoms are warranted.
Smoking cessation and counseling: A mixed methods study of pediatricians and parents
Authors: Simoneau Tregony , Hollenbach Jessica P. , Langton Christine R. , Kuo Chia-Ling , Cloutier Michelle M. 
Published: February 2021

Objective
Pediatric providers play an important role in parental and youth smoking cessation. The goal of this study was to understand smoking cessation attitudes of parents and the behaviors, confidence and self-efficacy of pediatricians related to providing smoking cessation counseling to parents and youth.

Methods
A mixed methods study was conducted in a convenience sample of families (n = 1,549) and pediatric primary care clinicians (n = 95) in Connecticut using surveys and focus groups from April, 2016 to January, 2017.

Results
The smoking rate (cigarettes or electronic cigarettes) among all households surveyed was 21%. Interest in quitting smoking was high (71%) and did not differ based on smoking amount, duration, type of community of residence (urban, rural, etc), or race/ethnicity. For example, compared to participants who smoked for <10 years, those who smoked ≥20 years had a similar interest in quitting (OR = 1.12; 95% CI: 0.85–1.48). Ninety percent of clinicians surveyed asked parents about their smoking behavior at least annually but 36% offered no smoking cessation counseling services or referral. Clinicians almost always reported counseling youth about the dangers of nicotine and tobacco use (99%), were more confident about counseling youth than parents (p<0.01) and reported low self-efficacy about smoking cessation and prevention counseling of parents and youth. Ninety-three percent of clinicians opined that electronic cigarettes were equally or more dangerous than cigarettes but 34% never counseled youth about the dangers of electronic cigarettes.

Conclusions
Clinicians frequently screen parents about their smoking behaviors, but rarely provide smoking cessation counseling and express low confidence in this activity. Clinicians are more confident counseling youth than parents. Clinicians also recognize the dangers of electronic cigarettes, yet they infrequently counsel youth about these dangers.
Prevalence and associated risk factors of gastritis among patients visiting Saint Paul Hospital Millennium Medical College, Addis Ababa, Ethiopia
Authors: Feyisa Zelalem Tadese , Woldeamanuel Berhanu Teshome 
Published: February 2021

Background
The health of individuals is not only the absence of disease checked medically, but also encompasses social and psychological aspects. Any departure from the state of physiological, psychological, or social well-being was affected by different factors. However, all contributory factors were not equally responsible for affecting disease. This study was undertaken as a search for the relative effects of sociocultural and individual behavioral factors contributing to acute and chronic gastritis patients visiting Saint Paul Hospital Millennium Medical College (SPHMMC).

Methods
A cross-sectional study was carried out on 364 patients visited SPHMMC in the study. Primary data were collected through an interview schedule tool with an exit approach by validating questions pertaining to sociocultural and individual behavioral factors. The status of gastritis was measured as whether patients had Helicobacter Pylori infection, signs and symptoms indicated gastritis that occurred, and persisted for less than a month, greater than a month, or none of the signs and symptoms. Descriptive statistics, bivariate analysis, and multivariable ordinal logistic regression model were used to identify the predictors of gastritis severity. P-value ≤ 0.05 was declared as an indicator of statistically significant.

Results
The prevalence of gastritis in the study area was 78.8%. Specifically, 48.9% and 29.9% had acute and chronic gastritis, respectively. The study found that low income and taking medicinal drugs was slightly significantly contributed to higher gastritis status; however, being younger age was slightly significantly contributed to lower gastritis status. Furthermore, the results indicated that eating spiced foods (Adjusted Odds Ratio (AOR) = 1.508; 95% CI: 1.046, 2.174), lack of physical exercise regularly (AOR = 1.780; 95% CI: 1.001, 3.168), stress (AOR = 2.168; 95% CI: 1.379, 3.4066), and substance use (AOR = 1.478; 95% CI: 1.093, 1.999) were significantly contributed to higher gastritis status.

Conclusions
The findings suggested that women should take enough rest and sleep well, men refrain from involvement in any risky behaviors, young people and those who earn low income per month should equip with knowledge and understanding on how to practice good health behaviors, eating foods on time, avoiding eating spiced food frequently, doing physical exercise regularly, and taking medicinal drugs according to physician advice are recommended.