bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overexpression of Catalase in Mitochondria Mitigates the Inflammatory Effects of Simulated Microgravity and Social Isolation in Mouse Hippocampus
Authors: Guttmann Linda , Schreurs Ann‐Sofie , Tahimic Candice , Torres Samantha , Steczina Sonette , Lowe Moniece , Ronca April , Globus Ruth 
Published: March 2021

Space flight missions are becoming longer and more common and evidence points to the physiological toll the missions have on the human body. Aging, sedentary lifestyle, and spaceflight have similar degenerative effects on almost every part of our body; both exposure to the space environment and aging result in cardiovascular deconditioning, bone loss, muscle atrophy, brain changes, and immune response impairment. We hypothesize that exposure to the space environment generates excessive Reactive Oxygen Species (ROS), which results in neuroinflammation and aging‐like degenerative symptoms in the brain. We used the hindlimb unloading (HU) model to mimic microgravity with either paired or single housed animals (social isolation). Responses to 30d of HU were compared in wildtype or transgenic MCAT mice, in which mitochondrial ROS is quenched by over‐expression of human catalase. Expression of 4‐Hydroxynonenal (4HNE) and Park7 (redox‐sensitive chaperone and sensor of oxidative stress) were measured by ELISA, a protein array quantified from the hippocampal cytokines and 8‐hydroxy‐2’‐deoxyguanosine in serum was measured by ELISA to assess oxidative DNA damage. Preliminary analysis of cage behavior patterns from video collected at the end of the study showed that MCAT HU mice (socially housed) were more active and conducted more exploratory activities compared to NL. Our biochemical results showed simulated microgravity and/or social isolation caused changes in levels of cytokines related to immune responses. Two‐way ANOVA revealed significant interaction effects of HU and genotype in expression levels of five cytokines (out of 35) in socially‐housed animals. Elevation of these generally pro‐inflammatory cytokines by HU in WT mice was mitigated in MCAT mice, suggesting a role for mitochondrial ROS signaling in inflammatory CNS responses to microgravity. Interestingly, some of these cytokines in the hippocampus displayed strong correlations to the 4HNE levels. We also found substantive cytokine responses to social isolation in the hippocampus; housing and genotype interaction effects were significant (by 2‐Factor ANOVA) for 15 cytokines, most of which were mitigated in MCAT mice.Taken together, our results showed that both simulated microgravity and social isolation influenced cytokine levels in the hippocampus and MCAT mice were at least partially protected from these changes. These findings implicate a potentially important role for mitochondrial ROS in CNS responses to the challenges posed by long duration spaceflight.Support or Funding InformationThis work is supported by a NASA Space Biology Grant to RKG (NNH14ZTT001N). LG was supported by a Space Biology NASA Postdoctoral Fellowship AwardThis abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Assessment of the left ventricular outflow tract during cardiac anaesthesia with biplane transoesophageal echocardiography
Authors: Cowie Brian , Bitcon Charles , Kluger Roman 
Published: March 2021

BACKGROUND
Assessment of left ventricular outflow tract (LVOT) area is a key component of quantification of aortic stenosis and stroke volume. Current international guidelines recommend measurement of the LVOT diameter with two-dimensional (2D) echocardiography and assume a circle. This may lead to erroneous measures of aortic valve area and adversely affect peri-operative decision making. Multiplane orthogonal (biplane) and three-dimensional (3D) echocardiography imaging may allow more accurate calculation of LVOT, aortic valve area and stroke volume.

OBJECTIVE
To evaluate the shape and area of the LVOT with conventional 2D diameter, short axis cross-sectional planimetry with biplane imaging and 3D multiplane reconstruction in patients undergoing cardiac surgery with transoesophageal echocardiography (TOE).

DESIGN
A retrospective observational study.

SETTING
A single centre university hospital.

PATIENTS
119 patients undergoing cardiac surgery with TOE.

INTERVENTIONS
None.

MAIN OUTCOME MEASURES
Measurements of the shape and area of the LVOT with standard 2D TOE, short axis biplane imaging and 3D TOE.

RESULTS
The LVOT shape is elliptical in 70% of patients. The (mean ± SD, [range]) LVOT cross-sectional area with 2D TOE was 4.29 cm2 ± 0.98, [2.46 to 6.70], with biplane was 4.68 cm2 ± 1.03, [2.92 to 7.30] and with 3D was 4.59 cm2 ± 0.99, [2.78 to 7.10]. There was a statistically significant difference (P < 0.001) in the three pairwise comparisons. 2D LVOT area had large bias (7 to 9%) and wider limits of agreement (LOA) with both biplane and 3D LVOT area (−17 to 36%). Biplane and 3D LVOT areas had small bias (1.8%) with relatively narrow LOA (−8 to 11%).

CONCLUSIONS
2D diameter measures of the LVOT assuming a circle underestimate LVOT area, underestimate aortic valve area and increase the apparent severity of aortic stenosis. This may lead to inappropriate aortic valve intervention. In a busy operating room environment, we suggest that for the calculation of stroke volume and aortic valve area, LVOT area is measured with biplane imaging.

TRIAL REGISTRATION
Observational study with no interventions so trial not registered.
Role of Dietary Factors, Food Habits, and Lifestyle in Childhood Obesity Development: A Position Paper From the European Society for Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition
Authors: Verduci Elvira , Bronsky Jiri , Embleton Nicholas , Gerasimidis Konstantinos , Indrio Flavia , Köglmeier Jutta , de Koning Barbara , Lapillonne Alexandre , Moltu Sissel Jennifer , Norsa Lorenzo , Domellöf Magnus 
Published: March 2021

ABSTRACT
Childhood obesity has high societal and economic impact but current treatment approaches are sub-optimal. In the last decade, important studies have been conducted aiming to identify strategies to prevent obesity during critical periods of life. Updated recommendations for childhood obesity prevention are needed. We present data from systematic reviews and meta- analysis, randomised controlled trials (RCTs) and large observational studies, published from 2011 onwards that consider the possible role of the following factors in obesity development: breast-feeding; macronutrient composition and method of complementary feeding; parenting style; dietary patterns; sugar-sweetened beverage consumption; eating behaviour (eg, skipping breakfast, family dinners. etc); meal frequency and composition (fast foods, snacking), portion size; dietary modulators of gut microbiota (including pre-, pro-, and synbiotics); physical activity and sedentary behaviour. We used the Medline database and the Cochrane Library to search for relevant publications. Important research gaps were also identified. This position paper provides recommendations on dietary factors, food habits, and lifestyle to prevent childhood obesity development, based on the available literature and expert opinion. Clinical research and high-quality trials are urgently needed to resolve numerous areas of uncertainty.
External Splinting Is Not Mandatory After All Rhinoplasties
Authors: Cabbarzade Cavid , Yücel Ömer Taşkin , Sözen Tevfik , Ozgen Burce 
Published: March 2021

Background
Although casts or external splint materials are commonly applied on the external nose after rhinoplasty, their beneficial effects have not been previously demonstrated in controlled studies.

Methods
A total of 40 adult patients who underwent primary rhinoplasty were included in this prospective study. The patients were randomized into 2 groups to use an external splint or not after surgery. Only surgical taping was applied to the nasal dorsum of the patients for whom external splints were not used. The periorbital edema and ecchymosis levels of the patients were recorded on the second and seventh days after surgery. Moreover, all patients had a computed tomography scan at the third postoperative week to measure the distance between the beginning of the osteotomy line on the right and left sides and the midline.

Results
On the second and seventh postoperative days, the levels of periorbital edema and ecchymosis were significantly lower in the patients with taping than in the patients with splints (P < 0.05 for each). No statistically significant difference was observed in terms of the difference in the distance between the beginning of the osteotomy line on the right and left sides to the midline between the group with external splints and that with tape (P = 0.661).

Conclusions
External splinting may not be used in cases where osteotomy is not performed or in patients where the osteotomies are sufficiently stable. Thus, the disadvantages of external splinting are avoided, and at the same time, periorbital edema and ecchymosis are less common.
Molecular dynamics study on atomic elastic stiffness at mode I crack along bi-metal interface
Authors: Yashiro K. 
Published: March 2021

Propagation of mode I crack along bi-metal (001) interfaces of Fe/W, Fe/Ni, Fe/Co and Ti/Mg is simulated by molecular dynamics and discussed with the eigenvalue/vector of the atomic elastic stiffness,

B

i
j

a

=
Δ

σ
i
a

/

Δ

ε
j

, and surface energy. The crack does not propagate at the interface but in the adjacent phase of smaller surface energy, except in Fe/Ni. The 1st eigenvalue
η

a
(1)

, or the solution of

B

i
j

a

Δ

ε
j

=

η
a

Δ

ε
i

of each atom, clarifies the difference of ‘soft/hard’ of both phases at the onset of crack propagation. In the case of Fe/Ni, the
η

a
(1)

of Ni atoms remarkably decreases in the Fe/Ni bi-metal structure, even though Ni has higher
η

a
(1)

than Fe at no-load perfect lattices. Thus the rupture occurs in the Ni side even though the Ni has slightly higher (001) surface energy than Fe. Deformation modes at the crack propagation are also visualized by the eigenvector of
η

a
(1)

< 0 unstable atoms.

This article is part of the theme issue ‘Fracture dynamics of solid materials: from particles to the globe’.
A unified first-order hyperbolic model for nonlinear dynamic rupture processes in diffuse fracture zones
Authors: Gabriel A.-A. , Li D. , Chiocchetti S. , Tavelli M. , Peshkov I. , Romenski E. , Dumbser M. 
Published: March 2021

Earthquake fault zones are more complex, both geometrically and rheologically, than an idealized infinitely thin plane embedded in linear elastic material. To incorporate nonlinear material behaviour, natural complexities and multi-physics coupling within and outside of fault zones, here we present a first-order hyperbolic and thermodynamically compatible mathematical model for a continuum in a gravitational field which provides a unified description of nonlinear elasto-plasticity, material damage and of viscous Newtonian flows with phase transition between solid and liquid phases. The fault geometry and secondary cracks are described via a scalar function
ξ
∈ [0, 1] that indicates the local level of material damage. The model also permits the representation of arbitrarily complex geometries via a diffuse interface approach based on the solid volume fraction function
α
∈ [0, 1]. Neither of the two scalar fields
ξ
and
α
needs to be mesh-aligned, allowing thus faults and cracks with complex topology and the use of adaptive Cartesian meshes (AMR). The model shares common features with phase-field approaches, but substantially extends them. We show a wide range of numerical applications that are relevant for dynamic earthquake rupture in fault zones, including the co-seismic generation of secondary off-fault shear cracks, tensile rock fracture in the Brazilian disc test, as well as a natural convection problem in molten rock-like material.

This article is part of the theme issue ‘Fracture dynamics of solid materials: from particles to the globe’.
Resolution and uncertainties in estimates of earthquake stress drop and energy release
Authors: Abercrombie Rachel E. 
Published: March 2021

Our models and understanding of the dynamics of earthquake rupture are based largely on estimates of earthquake source parameters, such as stress drop and radiated seismic energy. Unfortunately, the measurements, especially those of small and moderate-sized earthquakes (magnitude less than about 5 or 6), are not well resolved, containing significant random and potentially systematic uncertainties. The aim of this review is to provide a context in which to understand the challenges involved in estimating these measurements, and to assess the quality and reliability of reported measurements of earthquake source parameters. I also discuss some of the ways progress is being made towards more reliable parameter measurements. At present, whether the earthquake source is entirely self-similar, or not, and which factors and processes control the physics of the rupture remains, at least in the author's opinion, largely unconstrained. Detailed analysis of the best recorded earthquakes, using the increasing quantity and quality of data available, and methods less dependent on simplistic source models is one approach that may help provide better constraints.This article is part of the theme issue ‘Fracture dynamics of solid materials: from particles to the globe’.
Fracture asperity evolution during the transition from stick slip to stable sliding
Authors: Mei Cheng , Wu Wei 
Published: March 2021

Fracture asperities interlock or break during stick slip and ride over each other during stable sliding. The evolution of fracture asperities during the transition between stick slip and stable sliding has attracted less attention, but is important to predict fracture behaviour. Here, we conduct a series of direct shear experiments on simulated fractures in homogeneous polycarbonate to examine the evolution of fracture asperities in the transition stage. Our results show that the transition stage occurs between the stick slip and stable sliding stages during the progressive reduction in normal stress on the smooth and rough fractures. Both the fractures exhibit the alternative occurrence of small and large shear stress drops followed by the deterministic chaos in the transition stage. Our data indicate that the asperity radius of curvature correlates linearly with the dimensionless contact area under a given normal stress. For the rough fracture, a bifurcation of acoustic energy release appears when the dimensionless contact area decreases in the transition stage. The evolution of fracture asperities is stress-dependent and velocity-dependent.
This article is part of the theme issue ‘Fracture dynamics of solid materials: from particles to the globe’.
Complexities of underground mining seismic sources
Authors: Linzer Lindsay M. , Hildyard Mark W. , Wesseloo Johan 
Published: March 2021

This paper presents a numerical investigation on the influence of the mining environment on seismic sources, with a focus on pillar failure mechanisms in tabular mining. We investigate the influence of the mining stope (underground excavation or void) on seismic inversions for the scalar moment, corner frequency, source radius, stress drop and moment tensor using synthetic events created within elastodynamic numerical modelling software, WAVE3D. The main objective is to determine whether the source parameters calculated from the recorded waveforms are due to a combination of the stope source and the pillar sources, rather than being related only to crushing of the pillar or shearing in the pillar footwall. The main finding is that the presence of stopes, and types of pillars, have a significant impact on the seismic moment and other source parameters. This is important since the moment is viewed as a robust parameter on which seismic magnitude is often based; however, this study indicates that moments calculated for pillar failure in a tabular stoping environments are less representative of the shearing or crushing source than originally thought.This article is part of the theme issue ‘Fracture dynamics of solid materials: from particles to the globe’.
How do Hemodialysis Center Prevent the Secondary COVID-19 Transmission in Poverty-Stricken Rural Region of China: Experiences and Strategies
Authors: Gu Yue , Wang Yuming , Zhou Jing , Deng Yaorui , Shao Fengmin 
Published: March 2021

AbstractThe COVID-19 pandemic has caused an evolving public health crisis and challenged the medical system globally, especially in the rural-stricken regions. There is concern about the spread of coronavirus in regions with lower education level, weaker health systems and underdeveloped economy. The risk of viral transmission in HD center is elevated because of the densely-populated and high mobility in an enclosed environment.This paper demonstrated the main experiences and strategies of preventing secondary COVID-19 transmission in a HD center from a poverty-stricken rural region in China. Data of subjects including 17 medical workers and 249 patients were collected from the HD center in Huangchuan County People’s Hospital from February to April 2020. It is the first paper to provide the experiences and strategies about preventing COVID-19 secondary transmission in HD center for poverty-stricken rural region.
Blockchain technology for a sustainable agri-food supply chain
Authors: Rana Roberto Leonardo , Tricase Caterina , De Cesare Luigi 
Published: March 2021

PurposeThe present paper is aimed at 1) performing a systematic literature review (SLR) on applications in the perspective of sustainable agri-food supply chain (SC) of blockchain technology (BCT); 2) analyzing the selected literature, focusing on the advantages of the sustainable uses of the blockchain of the aforementioned SC and 3) presenting an outlook and research directions capable of addressing unresolved problems.Design/methodology/approachThe SLR was conducted using detailed criteria to identify academic articles. Moreover, specific keywords and databases were used. The time frame considered included the years 2010–2020.FindingsThe review analysis indicates that the use of BCT or BCT supported by ICT/IoT contributes to sustainability of agri-food production. However, this technology can lead to several challenges such as scalability, privacy leakage, high cost and connectivity problems.Research limitations/implicationsThe paper demonstrates that BCT can widely use agri-food supply chain due to its intrinsic characteristics. However, it is not excluded that the criteria chosen may not have identified important articles regarding BCT, the agri-food sector and sustainability.Originality/valueAlthough the body of academic literature published on this topic is expansive, the effect of BCT on the agri-food SC's sustainability aspects has not yet been adequately analyzed. Thus, the article is aimed at investigating how BCT is used in the SC. In particular, the article is intended to update information about BCT and its impact on sustainability.
Magnets of creative talents in Yangtze River Delta Bay area
Authors: Zhang Liuyi , Shi Anna , Fang Longzhang 
Published: March 2021

PurposeThis study aims to examine the spatial distribution and movement patterns of creative talent within the Yangtze River Delta Bay Area (YRDBA) and the factors that contribute to such trends.Design/methodology/approachThe study examines data for the period 2006 to 2018 from the regions that constitute the YRDBA: Shanghai, Jiangsu, Zhejiang and Anhui. Spatial distribution pattern analysis is adopted to interpret the flow tendency both spatially and chronologically and a Lasso regression model is used to investigate variables that influence this tendency.FindingsIt is found that creative talents in YRDBA are accumulating steadily in provincial capitals and financially advanced cities. Technology infrastructure, women’s rights, medical care amenities and housing affordability are major determinants of such spatial distribution. The talent spillover effect raises attention in talent saturated areas, while the surrounding regions should prepare to receive and retain the overflow.Originality/valueCreative talents geography in China and the dynamism of creative talent in YRDBA are rarely discussed. Determinants of creative talents lack systematic pectination, literature that filters multiple determinants of creative talents migration is limited and discussion specific to the Chinese context is scarce. This case can, thus, provide insights into creative talents in developing countries and add to the current literature, bridge the gap of the current understanding of creative talents in YRDBA – the innovation and development center in China and provide a reference for policymakers when making macro decisions.
The asymmetric impact of interest and exchange rate on the stock market index: evidence from MENA region
Authors: Moussa Faten , Delhoumi Ezzeddine 
Published: March 2021

PurposeSeveral theoretical and empirical studies have shown the significant effects of economic and environmental factors on a large number of financial indicators. In this paper the authors are going to study whether the main stock market index, is impacted by the variations of the exchange rate and the interest rates.Design/methodology/approachThis paper studies the response of the index market return to fluctuations in the interest rate and the exchange rate in five countries from the MENA region (Tunisia, Morocco, Egypt, Turkey and Jordan). To investigate whether this impact exists, the authors used the non-linear autoregressive distributed lag (NARDL) model with daily data from June 1998 to June 2018.FindingsThe application of the non-linear ARDL model confirms the presence of cointegration between return index, interest rate and exchange rate. The results show that the asymmetry hypothesis is only valid for the short run which suggests that the market index is sensitive to the variation in the interest rate and exchange rate. This means that these macroeconomic factors play an important role in the MENA region stock markets.Originality/valueThe findings confirm that the index returns in the MENA region stock markets are related to macroeconomic fundamentals such as the exchange rate and the real interest rate. The reaction of some indices is sensitive to whether the shocks are positive or negative. This finding may help investors to choose their strategies starting from these changes. Accordingly, policy makers must pay attention to the development progress of stock market.