bluuebunny/crossref_metadata_2025_split huggingface dataset:
EIA in developing countries: How does environmental impact assessment (EIA)/(AMDAL) support neoliberal mining? (a case study in Indonesia)
Authors: Kumayza T 
Published: November 2021

Abstract
Amdal regulation on mining exploitation according to Law No. 32 of 2009 aims to protect and manage the environment properly. This research reveals the paradox of EIA at the micro level (a case study) supporting the neoliberal agenda and facilitating economic development. This study aimed to explore how the practice of compensation for agricultural land at the scoping stage in the preparation of mining Amdal documents. The research was conducted in Mulawarman village, Kutai Kartanagara district, East Kalimantan province in the period 2004-2013. Historically, in the 2004-2013 period, Kutai Kartanegara Regency was the most massive in issuing mining business permits in Indonesia. The results of the study indicate that there was weak legal protection for agricultural land owners and unequal negotiation practices between companies and land owners without government supervision. The practice of compensation is a development tool rather than an environmental protection tool..
Circle of worry song video clip as a campaign medium to save the environment from damage
Authors: Ardianto D T , Riyanto B , Fajriani B 
Published: November 2021

Abstract
The Earth Day is commemorated every April 22nd to remind the importance of environmental protection. The environment that sustains our lives is getting weary over time. A group of filmmakers compiled a video clip consisting of environmental destruction events. This video clip is used as the background of a song entitled Circle of Worry. The purpose of this song clip production is to campaign for environmental protection. The video clip was made using creative collaboration method. The video was then distributed through social media and online platforms to reach broader audience, especially the younger generation. Through this media, it is hoped that the younger generation’s attention and awareness will emerge to better protect their environment.
Towards collective action in conflict resolution on environmental impacts due to coal mining in Indonesia
Authors: Sudarmo S 
Published: November 2021

AbstractThe Indonesian government has formally determined large-scale coal production to meet economic initiatives. This study uses the documentary method. The study found that coal mining activity has both positive and negative impacts. Coal mining creates environmental damage resulting in conflicts and advantaged and disadvantaged groups. The conflict resolution approach tends to be partial and has not resolved the problems associated with coal mining because the community tends to be victimized. Taking a participatory and inclusive collective action approach is essential to mitigate challenges coal mining entails because environmental problems require diverse stakeholders’ involvement. The commitment of coal mining entrepreneurs and the government’s concrete actions to minimize the negative impacts of coal mining cannot be further delayed which are to ensure the sustainability of Indonesia’s resources, human life, and the natural environment.
TDFragMapper: a visualization tool for evaluating experimental parameters in top-down proteomics
Authors: Dhenin Jonathan , Borges Lima Diogo , Dupré Mathieu , Chamot-Rooke Julia 
Published: November 2021

Abstract

Motivation
We present a new software-tool allowing an easy visualization of fragment ions and thus a rapid evaluation of key experimental parameters on the sequence coverage obtained for the MS/MS (tandem mass spectrometry) analysis of intact proteins. Our tool can process data obtained from various deconvolution and fragment assignment software.

Results
We demonstrate that TDFragMapper can rapidly highlight the experimental fragmentation parameters that are critical to the characterization of intact proteins of various size using top-down proteomics.

Availability and implementation
TDFragMapper, a demonstration video and user tutorial are freely available for academic use at https://msbio.pasteur.fr/tdfragmapper; all data are thus available from the ProteomeXchange consortium (identifier PXD024643).

Supplementary information
Supplementary data are available at Bioinformatics online.
An Examination of Intergenerational Contact Experiences Using 10,338 Journal Entries From 2,414 Young Adults
Authors: Lytle Ashley , Kowal Michael , Macdonald Jamie , Levy Sheri R 
Published: November 2021

Abstract

Background and Objectives
With continued negative depictions of older adults and limitations on positive intergenerational contact, ageism is a significant social issue. Using a rich data set of journal entries, we examined sentiments, emotions, and optimal intergenerational contact conditions among volunteers in an intergenerational program.

Research Design and Methods
10,338 journal entries were analyzed from 2,414 young adult volunteers from GlamourGals Foundation, Inc., a U.S. nonprofit, which aims to reduce isolation by facilitating intergenerational contact. Applying the PEACE (Positive Education about Aging and Contact Experiences) theoretical model, each sentence was coded using sentiment analysis, emotional analysis, and supervised learning methods across 5 optimal intergenerational contact conditions.

Results
Out of 74,475 sentences, participants reported predominantly positive sentiments (64.2% positive, 29% neutral, and 6.8% negative) and more positive emotions (e.g., joy) than negative emotions (e.g., disgust). Nearly all participants (98.2%) wrote at least a sentence that included at least 1 of the 5 optimal intergenerational contact conditions. Moreover, positive sentiment was present in higher percentages when more instances of optimal contact conditions were reported (54.4% for none, 71.6% for 1 category, 81.5% for 2, 83% for 3, 89.2% for 4, 98.4% for 5).

Discussion and Implications
The present investigation applied a theoretical model to assess a long-standing community intergenerational program. Contact that provided one-to-one, cooperative, equal status interactions involving personal disclosure that was sanctioned by the program administrators was associated with positive sentiment. Future directions and implications are discussed.
Dorsal telencephalon-specific Nprl2- and Nprl3-knockout mice: novel mouse models for GATORopathy
Authors: Ishida Saeko , Zhao Di , Sawada Yuta , Hiraoka Yuichi , Mashimo Tomoji , Tanaka Kohichi 
Published: November 2021

Abstract
The most frequent genetic cause of focal epilepsies is variations in the GAP activity toward RAGs 1 complex genes DEP domain containing 5 (DEPDC5), nitrogen permease regulator 2-like protein (NPRL2) and nitrogen permease regulator 3-like protein (NPRL3). Because these variations are frequent and associated with a broad spectrum of focal epilepsies, a unique pathology categorized as GATORopathy can be conceptualized. Animal models recapitulating the clinical features of patients are essential to decipher GATORopathy. Although several genetically modified animal models recapitulate DEPDC5-related epilepsy, no models have been reported for NPRL2- or NPRL3-related epilepsies. Here, we conditionally deleted Nprl2 and Nprl3 from the dorsal telencephalon in mice [Emx1cre/+; Nprl2f/f (Nprl2-cKO) and Emx1cre/+; Nprl3f/f (Nprl3-cKO)] and compared their phenotypes with Nprl2+/−, Nprl3+/− and Emx1cre/+; Depdc5f/f (Depdc5-cKO) mice. Nprl2-cKO and Nprl3-cKO mice recapitulated the major abnormal features of patients—spontaneous seizures, and dysmorphic enlarged neuronal cells with increased mechanistic target of rapamycin complex 1 signaling—similar to Depdc5-cKO mice. Chronic postnatal rapamycin administration dramatically prolonged the survival period and inhibited seizure occurrence but not enlarged neuronal cells in Nprl2-cKO and Nprl3-cKO mice. However, the benefit of rapamycin after withdrawal was less durable in Nprl2- and Nprl3-cKO mice compared with Depdc5-cKO mice. Further studies using these conditional knockout mice will be useful for understanding GATORopathy and for the identification of novel therapeutic targets.
EHR-based cohort assessment for multicenter RCTs: a fast and flexible model for identifying potential study sites
Authors: Nelson Sarah J , Drury Bethany , Hood Daniel , Harper Jeremy , Bernard Tiffany , Weng Chunhua , Kennedy Nan , LaSalle Bernie , Gouripeddi Ramkiran , Wilkins Consuelo H , Harris Paul 
Published: November 2021

Abstract

Objective
The Recruitment Innovation Center (RIC), partnering with the Trial Innovation Network and institutions in the National Institutes of Health-sponsored Clinical and Translational Science Awards (CTSA) Program, aimed to develop a service line to retrieve study population estimates from electronic health record (EHR) systems for use in selecting enrollment sites for multicenter clinical trials. Our goal was to create and field-test a low burden, low tech, and high-yield method.

Materials and Methods
In building this service line, the RIC strove to complement, rather than replace, CTSA hubs’ existing cohort assessment tools. For each new EHR cohort request, we work with the investigator to develop a computable phenotype algorithm that targets the desired population. CTSA hubs run the phenotype query and return results using a standardized survey. We provide a comprehensive report to the investigator to assist in study site selection.

Results
From 2017 to 2020, the RIC developed and socialized 36 phenotype-dependent cohort requests on behalf of investigators. The average response rate to these requests was 73%.

Discussion
Achieving enrollment goals in a multicenter clinical trial requires that researchers identify study sites that will provide sufficient enrollment. The fast and flexible method the RIC has developed, with CTSA feedback, allows hubs to query their EHR using a generalizable, vetted phenotype algorithm to produce reliable counts of potentially eligible study participants.

Conclusion
The RIC’s EHR cohort assessment process for evaluating sites for multicenter trials has been shown to be efficient and helpful. The model may be replicated for use by other programs.
The Midwife’s Tale: Conscientious Objection to Abortion after Grimmark and Steen
Authors: Brzozowski Wojciech 
Published: November 2021

Abstract
In early 2020, the European Court of Human Rights decided two cases of Swedish midwives who had been denied employment following their refusal to assist in performing abortions because of their religious beliefs: Grimmark v Sweden and Steen v Sweden. Surprisingly to many, their applications were declared inadmissible. This comment aims to determine whether they should indeed have been rejected at the preliminary stage and what message that ruling sent to a wider public regarding the Court's stance on the issue of conscientious objection. The author arrives at the conclusion that the two applications could have legitimately been expected to be fully examined and finds the Court's decisions highly unsatisfactory: not only do they demonstrate a regrettable lack of consideration with regard to the applicants' claims, but they also contribute to the ongoing uncertainty as to the Court's views on the limits of accommodation of conscience-based claims in healthcare and beyond.
Shopping, Identity, and Place
Authors: Campo Enrico 
Published: November 2021

Abstract
The (almost) universal extension of capitalist production and distribution processes has spread the “culture of consumption” to virtually every corner of the globe. This chapter discusses the relationship between spaces of consumption—shopping malls in particular—and the processes of identity construction. It begins with a brief review of the first works to examine consumption and its spaces without viewing them as neutral backgrounds where the distribution of goods would take place, but rather as physical and symbolic spaces in their own right. Further on, recent approaches that have been most influenced by symbolic interactionism are also analyzed. These perspectives, by putting the actor’s point of view and their concrete daily practices at the center of research, understood the processes of identity negotiation and the practice of shopping as an ordinary, contextual, and situated activity.
An Intersectional Analysis of Labor Market
Outcomes
Authors: Brooks Jennifer D. 
Published: November 2021

Abstract
Recent work highlights the importance of intersectionality to the study of the economic and labor market inequalities of those with disabilities. Yet, little attention has been given to examining the causes and consequences of these intersectional effects. The current chapter expands on previous research by (1) examining how race/ethnicity, gender, and disability status work in tandem to shape employment probabilities among working-age adults with disabilities and (2) whether potential disparities among these groups can be explained by government assistance receipt. This chapter uses data from the 2017 American Community Survey (ACS) to estimate a series of logistic regression models predicting employment from 16 race-gender-disability groups. Results provide evidence for a “spillover effect” where the disadvantages or advantages an individual acquires from the combination of their status-based characteristics spill over to affect their employment probabilities. This spillover effect may result from the multiplicative effects of race/ethnicity, gender, and disability status on institutions, including employment and government assistance, intertwining to create and maintain hierarchies of disadvantage, leading to overlapping institutions of oppression.
Infrastructures of Soviet Underground Culture
Authors: Parisi Valentina 
Published: November 2021

Abstract
Institutions of the late Soviet underground (here understood following Peter Bürger as the norms governing the production and reception of works of art) consisted of atypical, small-scale, ephemeral, self-organized infrastructures such as, for example, samizdat periodicals, readings, exhibitions, conferences held in private apartments. Geographically not limited to Moscow and Leningrad, they allowed participants to carry on their creative activities in an uncensored way; nevertheless, they were shaped in a complex dialectic with highbrown, authoritative forms such as thick journals or academic seminars. Alternative topographies were established and symbolically charged places were temporarily taken and appropriated. In the second half of the 1970s underground institutions underwent a gradual process of consolidation and served to the conceptualization of the so-called second culture in reference to neglected pre-revolutionary legacy and to Soviet official culture.
The Title IX Movement Against Campus Sexual Harassment
Authors: Cantalupo Nancy Chi 
Published: November 2021

Abstract
Beginning in 2009, hundreds of thousands of students and their allies began to mobilize against campus sexual assault, organizing around the groundbreaking civil rights statute, Title IX of the Education Amendments of 1972, and achieving remarkable progress in advancing gender equality in only about a decade. Moving from the Title IX movement’s genesis during the Obama administration to the movement’s direct-action protests and litigation challenging regulations issued in May 2020 by then-Secretary of Education Betsy DeVos, this chapter tells the story of how Title IX and the student movement interacted from 2009 to 2020. During these years, the movement not only weathered backlash but also influenced later feminist movements such as #MeToo and nonfeminists’ understanding of sexual harassment, demonstrating the continued power and promise of both feminist law and feminist organizing.
Beyond Battered Women’s Syndrome
Authors: Buel Sarah M. 
Published: November 2021

Abstract
Feminist jurisprudence has amplified the voices of gender violence survivors long silenced by trauma and male-biased legal doctrine. In critiquing self-defense law’s treatment of survivors, some feminists pressed for recognition of a distinctive set of characteristics purportedly associated with survivors, termed “battered woman syndrome” (BWS). Intended to ameliorate the harsh effects of criminal law on survivors, BWS sought to explain why battered women responded as they did in terms that judges and juries might better relate to the legal requirements for self-defense. One argument is that the law of self-defense must be further recalibrated—beyond the problematic, operative lens of BWS—to better protect those who engage in survival crime. By instead utilizing “battering and its effects” as the framework for relevant evidence, the criminal justice system could become more responsive to survivors. Even beyond recalibrating the law of self-defense to better suit survivors, legal stakeholders can learn much from activists and feminist legal theory about pursuing gender and racial justice, by embracing diverse lenses to actually hear the raced, classed, and gendered narratives of survivors’ lives. Despite missteps with the development of BWS, feminist jurisprudence is gradually increasing understanding of, and empathy for, survival crime.
Search for host defense markers uncovers an apple agglutination factor corresponding with fire blight resistance
Authors: Chavonet Erwan , Gaucher Matthieu , Warneys Romain , Bodelot Antoine , Heintz Christelle , Juillard Anthony , Cournol Raphaël , Widmalm Göran , Bowen Joanna K , Hamiaux Cyril , Brisset Marie-Noëlle , Degrave Alexandre 
Published: November 2021

Abstract
Pathenogenesis-related (PR) proteins are extensively used as molecular markers to dissect the signaling cascades leading to plant defense responses. However, studies focusing on the biochemical or biological properties of these proteins remain rare. Here, we identify and characterize a class of apple (Malus domestica) PR proteins, named M. domestica AGGLUTININS (MdAGGs), belonging to the amaranthin-like lectin family. By combining molecular and biochemical approaches, we show that abundant production of MdAGGs in leaf tissues corresponds with enhanced resistance to the bacterium Erwinia amylovora, the causal agent of the disease fire blight. We also show that E. amylovora represses the expression of MdAGG genes by injecting the type 3 effector DspA/E into host cells and by secreting bacterial exopolysaccharides. Using a purified recombinant MdAGG, we show that the protein agglutinates E. amylovora cells in vitro and binds bacterial lipopolysaccharides at low pH, conditions reminiscent of the intercellular pH occurring in planta upon E. amylovora infection. We finally provide evidence that negatively charged polysaccharides, such as the free exopolysaccharide amylovoran progressively released by the bacteria, act as decoys relying on charge–charge interaction with the MdAGG to inhibit agglutination. Overall, our results suggest that the production of this particular class of PR proteins may contribute to apple innate immunity mechanisms active against E. amylovora.
Early Monitoring and Subsequent Gain of Tacrolimus Time-In-Therapeutic Range May Improve Clinical Outcomes After Living Kidney Transplantation
Authors: Yin Saifu , Huang Zhongli , Wang Zhiling , Fan Yu , Wang Xianding , Song Turun , Lin Tao 
Published: November 2021

Background:
The early identification of recipients at high risk of graft loss is clinically relevant after kidney transplantation. The authors explored whether the earlier monitoring of tacrolimus (Tac) time-in-therapeutic range (TTR) is predictive of and a subsequent gain in TTR improves transplant outcomes.

Methods:
The TTR within 3, 6, 9, and 12 months was evaluated. Multivariate Cox analyses were performed to explore when TTR was predictive of transplant outcomes. Patients were divided into 3 groups based on incremental TTR change [TTR gain (increase >10%), TTR stable (maintained within 10%), and TTR loss (decrease >10%)] and 4 groups based on predefined cutoff values [low–low (LL), low–high (LH), high–low (HL), and high–high (HH)] using 6- and 12-month TTRs. Death-censored graft loss and patient death were primary outcomes.

Results:
Nonlinear associations were observed between 6-, 9-, and 12-month TTR and death-censored graft and patient survival rates. In multivariate analysis, every 10% increase in 6-, 9-, and 12-month TTRs was associated with reduced patient death [hazard ratio (HR): 0.83; HR: 0.68; HR: 0.61, respectively] and graft loss (HR: 0.88; HR: 0.73; HR: 0.66, respectively). A nonlinear relationship was observed between transplant outcomes and incremental changes in TTR. TTR gain and stable TTR contributed to higher graft survival (HR: 0.20; HR: 0.21) and patient survival (HR: 0.14; HR: 0.15) rates than TTR loss, whereas the former 2 had comparable outcomes. Furthermore, compared with those in the HH group, the LL and HL groups had inferior graft survival (HR: 3.33; HR: 5.17) and patient survival (HR: 5.15; HR: 8.94) rates, whereas the LH group had similar outcomes (P = 0.63, P = 0.97). Nonadherence was the main controllable risk factor for low TTR.

Conclusions:
The 6-month TTR identified patients at higher risk of worse outcomes. The subsequent gain of TTR may contribute to better transplant outcomes.
Association of the Circulating Supar Levels with Inflammation, Fibrinolysis, and Outcome in Severe Burn Patients
Authors: Lin Jian-Chang , Chen Xiao-Dong , Xu Zhao-Rong , Zheng Lin-Wen , Chen Zhao-Hong 
Published: November 2021

ABSTRACT

Background:
Hyperfibrinolysis and pro/anti-inflammatory imbalance usually occur in the early stage of severe burns. Soluble urokinase-type plasminogen activator receptor (suPAR) is involved in fibrinolysis and inflammation. To date, the levels of circulating suPAR in non-survivors with severe burns remain unknown. This study aimed to investigate the early association between circulating suPAR levels and biomarkers of fibrinolysis, pro/anti-inflammatory, and prognosis.

Methods:
Sixty-four consecutive Chinese patients with severe burns and 26 healthy volunteers were enrolled in a prospective observational cohort. Clinical characteristics and laboratory data were collected prospectively. Blood samples were collected at 48 h post-burn, and suPAR and biomarkers of pro/anti-inflammatory and fibrinolysis were detected by enzyme-linked immunosorbent assays. Important indicators between non-survivors and survivors were compared. Linear regression analysis was performed to screen variables associated with suPAR. Logistic regression analysis and receiver operating characteristic curve (ROC) analysis were performed to evaluate the prognostic value of suPAR.

Result:
Compared with the control group, the circulating suPAR levels in the survivors (P < 0.001) and non-survivors (P = 0.017) were higher. Compared with survivors, non-survivors had lower circulating suPAR levels at 48 h post-burn, and they showed a higher degree of fibrinolysis (higher D-dimer) and a lower TNF-α/IL-10 ratio. According to linear regression analysis, the variables independently associated with a lower suPAR level were lower platelet factor 4 (PF-4), urokinase-type plasminogen activator (uPA), and TNF-α/IL-10 levels and a higher D-dimer level. Logistic regression and ROC analyses indicated that a suPAR level ≤ 4.70 μg/L was independently associated with 30-day mortality.

Conclusion:
Low circulating suPAR levels at 48 h post-burn in severe burn patients may reflect decreased TNF-α/IL-10 ratio and increased hyperfibrinolysis. suPAR can predict 30-day mortality in patients with severe burn.