bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Value of CA125 Serum Levels in Female Patients with Acute Coronary Syndrome
Authors: Luo YanHong , Cheng YongRan , Zhang XiaoFu , Wang MingWei , Ni Bin , Yang ZhiQiang , Ge ZhongJun , Zhang XingWei , Pan ChunQi 
Published: April 2021

Abstract
Background: carbohydrate antigen 125 (CA125) is an increasingly promising biomarker of heart failure (HF), but its prognostic value in female patients with acute coronary syndrome (ACS) is unclear. We aimed to determine the short-term and mid-term prognostic value of CA125 serum levels in female ACS patients.Methods: A total of 131 consecutive female patients with ACS were retrospective enrolled. Their CA125 levels, B-type natriuretic peptide (BNP) levels and biochemical parameters were measured, and echocardiography was performed at admission. All-cause mortality during hospitalization and two-year follow-up was investigated for the prognosis.Results: The median value of CA125 serum level in the entire ACS patients was 13.85 U/mL. Patients in Killip Ⅲ had the highest values of CA125 level, followed by Killip Ⅱ and then Killip Ⅰ (p < 0.05). However, no statical difference was observed between Killip Ⅳ and Ⅰ-Ⅲ groups respectively (P > 0.05). The CA125 serum levels showed weak positive correlation with left ventricular end-diastolic diameter (LVEDD) (r = 0.3, P < 0.01) and a weak negative correlation with left ventricular ejection fraction (LVEF) (r = –0.23, p < 0.01). A receive operating characteristic (ROC) curve analysis showed that the AUC of CA125 in predicting acute heart failure (AHF) in ACS patients during hospitalization was 0.912, exhibiting higher sensitivity and specificity than BNP (0.846). The optimal cut-off value for CA125 in predicting AHF was 16.4 U/mL with a sensitivity of 0.916 and specificity of 0.893. The Kaplan-Meier survival analysis demonstrated that patients with high values of CA125 level had a poor overall survival than those with low values of CA125 level (log-rank, p < 0.001), whether during hospitalization or mid-term follow-up. Conclusion: Elevated CA125 level can be used to predict AHF in female ACS patients. Patients with elevated CA125 levels had higher mortality in short-term and mid-term than those with low CA125 levels.
The Correlation of Cycloplegic Refraction with Corneal Radius of Curvature-Adjusted Axial Length in Chinese Preschoolers
Authors: Zhou Xiao-hong , Li Yian , Wang Wei , Yang Chen-hao 
Published: April 2021

Abstract
Background: In order to master the refractive status and detect severe refractive errors quickly and effectively, this study aimed to investigate the association of axial length after adjusting for corneal radius of curvature with refraction in a group of Chinese preschoolers.
Methods: Retrospective review of 716 Chinese children aged from 3 to 6 years, who underwent cycloplegic optometry with 1% atropine eye gel in the ophthalmology department of Children’s Hospital of Fudan University, National Children’s Medical Center in Shanghai. Meanwhile axial length, corneal radius of curvature and cycloplegic autorefraction were obtained and axial length/corneal radius of curvature (AL/CR) ratio was calculated. The correlations of spherical equivalent refraction (SER) with axial length, corneal radius of curvature, AL/CR ratio and corneal radius of curvature-adjusted axial length were analyzed.
Results: Only data from the right eye were included in this analysis. Among 716 eyes of 716 Chinese preschoolers, the mean (±SD) SER was 2.28±2.41 diopters (D), of which hyperopia, emmetropia, myopia were 84.64%, 8.54%, 6.84%, respectively. The mean(±SD) axial length, corneal radius of curvature and AL/CR ratio were 21.89±1.01mm, 7.76±0.27 mm, and 2.82±0.13, respectively. The SER was highly negative correlated with both axial length (coefficient –0.722) and AL/CR ratio (coefficient-0.814), and weakly correlated with corneal radius of curvature (coefficient 0.090) and gender(coefficient 0.093). Axial length was weakly correlated with age and gender(coefficient 0.232 and 0.268, respectively), but moderately correlated with corneal radius of curvature (coefficient 0.424). After adjusting for corneal radius of curvature, the correlation coefficient between SER and axial length significantly increased to-0.918.
Conclusion: In the samples of 716 3-to 6-year-old Chinese children, axial length was moderately correlated with corneal radius of curvature. After adjusting for corneal radius of curvature, refraction was closely correlated with axial length than axial length alone and AL/CR ratio. Therefore, corneal radius of curvature-adjusted axial length might be a useful tool for pediatric ophthalmologists to detect refractive errors.
Key Words: spherical equivalent refraction; corneal radius of curvature; adjusted; axial length; preschoolers.
A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Assessing the Efficacy of Magnesium Oxide Monohydrate in the Treatment of Nocturnal Leg Cramps
Authors: Barna Olha , Lohoida Pavlo , Holovchenko Yurii , Bazylevych Andrii , Velychko Valentyna , Hovbakh Iryna , Bula Larysa , Shechter Michael 
Published: April 2021

Abstract
Background

Magnesium supplements are widely used for prophylaxis and treatment of nocturnal leg cramps (NLC). However, there is little evidence in support of their effectiveness. The main impediment stems from the lack of assessments of cellular absorption. In the current study, we tested the efficacy and safety of a magnesium supplement – magnesium oxide monohydrate (MOMH), for which increased cellular absorption rates were demonstrated in an ex-vivo setting.
Methods

A randomized, double-blind, placebo-controlled multicenter study was conducted in hospitals and outpatient clinics in Ukraine, from February to August 2018. Eligible subjects received a capsule with MOMH 226mg or placebo, once daily, at bedtime, for a 60day period. The assessed parameters included frequency and duration of NLC episodes, quality of sleep, NLC-induced pain and quality of life sub-scores. The Fisher's Exact Test for comparison of groups by categorical variables was used. The Student’s test or Mann-Whitney test were used for between-group comparison at different timepoints. ANCOVA followed by contrast analysis was used for comparison of groups at the end of the study.
Results

175 (81%) out of 216 initially screened subjects completed the study. The number of NLC episodes has significantly decreased by the end of the study period as compared to baseline in both groups (p < 0.001 for both). There was a significant between-group difference in the magnitude of reduction in NLC episodes (p = 0.01), indicating a higher decrease in the MOMH group as compared to the placebo group (-3.4 vs -2.6, respectively). In addition, MOMH treatment resulted in a greater reduction in NLC duration (p < 0.007) and greater improvement in sleep quality (p < 0.001) as compared to placebo.
Conclusions

MOMH was shown to be effective in the treatment of NLC as well as safe and well-tolerated.
ClinicalTrials.gov identification number:

NCT03807219, retrospectively registered on January 16, 2019.
Treatment with immunotherapy and other systemic therapies for patients with recessive dystrophic epidermolysis bullosa and cutaneous squamous cell carcinoma. A single institution experience.
Authors: Viñal David , Martinez-Fdez Sara , Ostios Lorena , Maseda Rocio , de Lucas Raul , Castelo Beatriz 
Published: April 2021

Abstract
Purpose. Cutaneous squamous cell carcinoma (CSCC) is a frequent complication in patients with recessive dystrophic epidermolysis bullosa (RDEB). Immunotherapy is a novel treatment approach for CSCC, however there is little experience in patients with RDEB. Methods. We included all the patients with a molecular-confirmed diagnosis of RDEB and advanced CSCC treated with systemic therapy between November 1988 and January 2021. Results. Five patients were treated with immunotherapy (n = 2), other systemic therapies (n = 2), or both (n = 1). The tolerability of immunotherapy was overall acceptable with no treatment-related serious adverse events. Radiological tumor response observed in one patient. The other patients were treated with a combination of chemotherapy and targeted therapy (EGFR inhibitors), with mixed tumor response. Median OS was 3 months (range, 1 to 11). Conclusions: Patients with RDEB and advanced CSCC benefit from immunotherapy and do not experience unexpected toxicity.
Kernel Density Estimation and Correntropy based Background Modeling and Camera Model Parameter Estimation for Underwater Video Object Detection
Authors: Panda Susmita , Nanda Pradipta Kumar 
Published: April 2021

Abstract
Underwater video object detection is challenging because of the complex background and the movement of the camera. In order to address this, we propose a novel scheme of simultaneously estimating the camera model parameters and detecting the object. The object detection phase includes background modeling and its learning. Background is modeled by the proposed Spatial Kernel Density Estimation (SKDE) model and the model learning happens in the SKDE feature space. Background modeling and its learning is pixel based approach. The model histograms learn the new pixel through its histogram representation. Our learning and classification strategy is different from the Heikkila et al. [17] in the context of similarity measure. We have proposed the correntropy based similarity measure that is used for model learning and pixel classification. The camera model parameters are estimated by 2D optimization method where we have used the corner features of an object at subpixel accuracy level. These subpixel level features are used in the proposed pipelining framework for model parameters estimation. The estimated model parameters are used to transform the input frame, which in turn is used for model learning and classification. The proposed scheme has been tested with underwater video frames from six data sets. The efficacy of the proposed scheme is compared with seven existing schemes and it is found that the proposed scheme exhibits improved performance as compared to the existing methods.
Diagnosis of Orthostatic Tremor Using Smartphone Accelerometry Running Head: Smartphone Accelerometry for Orthostatic Tremor
Authors: Calvo Nicholas E. , Ferrara Joseph M. 
Published: April 2021

Abstract
Background: Primary orthostatic tremor (OT) is a rare movement disorder characterized by a 13-18 Hz leg tremor, which arises when standing and is relieved by walking/sitting. Those affected generally do not fall, but experience fear of falling, lessened by ambulation. Because of its low amplitude, the tremor is not readily visible, and diagnosis requires confirmation with surface electromyography. Recently, applications using the accelerometer feature of smartphones have been used to detect and quantify tremors, including OT, though the accuracy of smartphone accelerometry in diagnosing OT is unknown. Methods: We completed SPA in consecutive adults (18+ years), who presented to our neurology clinic with either subjective leg shakiness upon standing or unsteadiness when standing that lessened with ambulation. We assessed tremor using the StudyMyTremor application on an iPhone 6s adhered with tape to the patient’s tibialis anterior. Surface electromyography was completed on the same muscle. The primary outcome of this study was to determine SPA’s sensitivity and specificity in detecting OT compared with surface electromyography. Results: Fifty-nine patients with the following diagnoses were included: OT (6), Parkinson’s disease, Hereditary Spastic Paraplegia, orthostatic hypotension, essential tremor, spinal cerebellar ataxia, sensory ataxia and functional movement disorder. Smartphone accelerometry detected a 13-18 Hz tremor in 5 of 6 patients diagnosed with OT by surface electromyography with no false positives in other conditions, yielding a sensitivity of 83%, specificity of 100% in the cohort we studied. Conclusions: Though a larger sample size is desirable, preliminary data suggest that smartphone accelerometry is an alternative to surface electromyography in diagnosing OT.
Laparoscopic Surgery in 3D Improves Results and Surgeon Convenience in Sleeve Gastrectomy for Morbid Obesity
Authors: Martinez-Ubieto Fernando , Barranco-Dominguez Ignacio , Tardós-Ascaso Lucía , Jiménez-Bernadó Teresa , Pascual-Bellosta Ana , Aragón-Benedí Cristian , Ramírez-Rodriguez Jose Manuel , Martínez-Ubieto Javier 
Published: April 2021

Abstract
Background. Advanced laparoscopic procedures are still challenging. One critical issue is the lack of stereoscopic vision. The aim of this surgical study is to evaluate whether 3D vision offers any advantages for surgical performance over 2D vision during sleeve gastrectomy for morbid obesity using a laparoscopic system that allows changing between 2D and 3D optics.Method. A total of 78 patients were analyzed, with 37 in the 2D group and 41 in the 3D group. Performance time, hospital stay, complications and early outcomes were collected. To assess the quality of the 2D and 3D techniques, visual analog scales (VASs) from 0 to 10 were designed, and image quality, depth of field, precision in performing tasks and general ergonomics were measured.Results. According to the vision system used, the mean duration of surgery was 85 ± 16.8 minutes for patients operated on with the 2D system and 69 ± 16.9 minutes for those operated on with the 3D system. There were no significant differences between the overall percentages of complications according to the type of vision used. However, postoperative complications were more severe in the 2D laparoscopy group. The average length of stay was shorter for patients in the 3D group. Regarding the differences perceived by the surgeon, the depth of field and the precision of tasks were better in the 3D vision group.Conclusion. The 3D system provided greater depth perception and precision in more complex tasks, enabling safer surgery. This led to a reduction in the operative time and hospital stay. Moreover, the severity of complications was less.
A Novel Approach to Predicting Interactions Between Microbes and Hosts
Authors: Li Jie , Chen Zhuo , Ma Dawei , Zhou Li , Wang Yadong 
Published: April 2021

Abstract
Increasing evidence shows that microbes are important for the protection of human health and the health of other living organisms. At the same time, microbes can cause other organisms to become sick or even die. Through microbe–host interaction, we can understand intuitively the process and mechanism of host infection by microbes. Several methods are developed to predict microbe–host interactions. However, current methods are limited by the cost of interaction verification experiments and accuracy. Therefore, there is still a need for a rapid and accurate method to predict microbe–host interaction. Here, we proposed a novel method based on Integrated Similarity, KATZ measure, and Within and Between Scores (ISKATZWBS) to predict microbe–host interactions. Experimental results show that the proposed method performs well and the AUCs are 0.946, 0.981, 0.954 on the PHI-base, HPIDB, and HMDAD datasets repectively. Compared with other four state-of the-art methods: KATZHMDA, WBSMDA , NGRHMDA and NCPHMDA, the proposed method has higher prediction accuracy.
Auditory Verbal Hallucination-Specific Functional Brain Networks in Schizophrenia: A Study Based on Graph Theory
Authors: Yang Weiliang , li Yan , Cao Haiyan , Qin Wen , Cheng Yongying , Xu Shuli , Chen Jiayue , Li Jie 
Published: April 2021

Abstract
Background

Although mounting previous studies have characterized auditory verbal hallucinations (AVH) related brain network abnormalities in the patients with schizophrenia, AVH related brain network alterations based on graph theory was rarely reported. In addition, the relationship between the features of AVH related brain networks based on graph theory and clinical features of schizophrenia patients with AVH is unclear. Our study to explore associations among network metrics, and clinical features in schizophrenia patients with AVH.
Method

Thirty-one schizophrenia patients without AVH, 17 patients with AVH, and 31 healthy controls were examined by functional magnetic resonance imaging. Graph theory method was performed to analyze the topological properties of functional network in three groups.
Results

Our results showed that schizophrenia patients with AVH displayed decreased local network efficiency, clustering coefficients, and nodal efficiency of the right dorsolateral prefrontal cortex. Local network efficiency was positively correlated with AVH characteristics.
Conclusion

The topological properties of brain functional networks are disrupted in schizophrenia patients with AVH, suggesting a role of functional brain networks in the pathogenesis of AVH.
Application of Multidisciplinary Team (MDT) in The Treatment of Severe Maxillofacial Trauma: A Retrospective Study
Authors: Sun Xu , Tong Shuang , Yang Shude , Guo Shu 
Published: April 2021

Abstract
Background: The severe maxillofacial injuries often involves multiple systems and locations, requiring multiple surgical specialties to participate in injury assessment, emergency surgery and follow-up planned staged surgery, thus requiring the participation and guidance of a multidisciplinary team. This study explores the treatment effect of this model on patients with severe maxillofacial trauma, so as to better promote the standard of severe maxillofacial trauma treatment, aiming to establish a scientific and standardized system of severe trauma treatment. Method: We retrospectively analyzed the treatment process of 173 patients with severe maxillofacial trauma, including timely, orderly, and efficient out-of-hospital emergency treatment. Maxillofacial surgery led the in-hospital treatment, and coordinated with other disciplines to relieve respiratory obstruction, control bleeding, correct shock and save lives. We summarized the experience in the treatment of jaw fracture reduction and internal fixation after the condition was stable. Result: With the specialist treatment and close multidisciplinary cooperation, the treatment effect was good, and the reduction and internal fixation of jaw fractures had achieved satisfactory results. Conclusion: Multidisciplinary coordinated emergency treatment of severe maxillofacial trauma is an effective measure to improve the success rate of treatment.
Concentrations of Oligosaccharides in Human Milk and Child Growth
Authors: Menzel Philipp , Vogel Mandy , Austin Sean , Sprenger Norbert , Grafe Nico , Hilbert Cornelia , Jurkutat Anne , Kiess Wieland , Binia Aristea 
Published: April 2021

Abstract
Background: The relationship between human milk oligosaccharides (HMO) and child growth has been investigated only insufficiently with ambiguous results. Therefore, this study examines potential influencing factors of HMO concentrations and how HMOs are associated with child growth parameters.Methods: Milk samples from the German LIFE Child cohort of healthy children were analyzed for 9 HMOs. Putative associations with maternal and child cofactors and child height, head circumference and BMI between three months and seven years of age were examined. Secretor status, defined as the presence of 2’-fucosyllactose, was investigated for associations with infant outcomes.Results: Our population consisted of 21 (14.7%) non-secretor and 122 (85.3%) secretor mothers. Maternal age was significantly associated with higher 3’SL concentrations; gestational age was associated with LNT, 6’SL and LNFP-I. Pre-pregnancy BMI was negatively associated with LNnT only in non-secretors. The growth velocity of non-secretors’ children was inversely associated with LNnT at 3 months to 1 year (R=0.95 [0.90, 0.99], p=0.014), 1 to 2 years (R=0.80 [0.72, 0.88], p<0.001) and 5 to 6 years (R=0.71 [0.57, 0.87], p=0.002). 2’FL was negatively associated with BMI consistently, reaching statistical significance at 3 months and 4 and 5 years. Children of non-secretors showed higher BMI at 3 months, 6 months, and 3, 6, and 7 years of age.Conclusion: We found that some associations between HMOs and infant growth may extend beyond the infancy and breastfeeding periods. They highlight the importance of both maternal and infant parameters in the understanding of the underlying associations.Trial registration: The study is registered with ClinicalTrial.gov: NCT02550236.
Regional Grey Matter Microstructural Changes and Volume Loss Regarding Disease Duration in Multiple Sclerosis Patients
Authors: Solana Elisabeth , Martinez-Heras Eloy , Montal Victor , Vilaplana Eduard , Lopez-Soley Elisabet , Radua Joaquim , Sola-Valls Nuria , Montejo Carmen , Blanco Yolanda , Pulido-Valdeolivas Irene , Sepúlveda Maria , Andorra Magi , Berenguer Joan , Villoslada Pablo , EH Martinez-Lapiscina , Prados Ferran , Saiz Albert , Fortea Juan , Llufriu Sara 
Published: April 2021

Abstract
The spatio-temporal characteristics of grey matter (GM) impairment in multiple sclerosis (MS) are poorly understood. We used a surface-based diffusion MRI processing tool to investigate regional modifications of microstructure and volume loss in GM at different time-points of the disease, and their relationship to disability. We studied 54 healthy controls and 247 MS patients classified according to disease duration: MS1 (less than 5 years, n=67); MS2 (5-15 years, n=107); and MS3 (more than15 years, n=73). We compared GM mean diffusivity (MD) and volume between groups, and estimated their clinical correlations. Regional modifications in MD and volume did not overlap early in the disease, and became widespread in later phases. We found higher MD in MS1 group, mainly in the temporal cortex, and volume reduction in right putamen. Additional MD changes were evident in cingulate and occipital cortices in the MS2 group, coupled to volume reductions in deep GM and parietal and frontal poles. Changes extended to more than 80% of regions in MS3 group. Clinical disability was correlated with GM changes. Microstructural integrity loss and atrophy present differential spatial predominance early in MS and accrual over time, probably due to distinct pathogenic mechanisms that underlie tissue damage.
The treatment of pectus carinatum with the bracing after surgery for congenital heart disease: experience from a single institution
Authors: He De-rong , Zha Jing-jing , Hong Song-ming , Hong Jun-jie , Huang Jin-xi , Cao Hua 
Published: April 2021

Abstract
Purpose:Secondary pectus carinatum (PC) after surgery for congenital heart disease(CHD) has its own clinical characteristics.Conservative treatment of PC with bracing is an attractive alternative to surgical repair.This study was to investigate the effects of the bracing on treating pediatric patients with PC after heart surgery.Methods:We conducted a retrospective study of all patients who had PC after surgery for CHD with median sternotomy from March 2019 to December 2020.Monthly follow-up with anterior–posterior(AP) width measurements.The size of bracing is designed based on the patient’s anterior chest wall.Result:Twenty four patients (3/2019–12/2020) were conducted into this retrospective study in the clinic,and 22 patients(91.66%) achieved excellent correction.The twenty four patients were distributed into three stages(stage 1: treated for 0 month,stage 2:treated for 3 months, stage 3: treated for 6 months).We found statistically significant differences in the AP between stage 2 and stage 1(AP p<0.01),stage 3 and stage 2(AP p<0.01).The main side effects were mild subcutaneous hematoma,petechial bleeding and chest tightness.There was no children complicated with hydropericardium or cardiac tamponade.Conclusion:The bracing has been shown to be a safe and effective approach for the treatment of the pediatric patients with PC after surgery for CHD.