bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Massenfertigung” mit Losgröße Eins
Authors: Schulz Dirk , Lithoxopoulos Christos , Simora Lars 
Published: May 2021

Losgröße Eins - die kosteneffiziente Herstellung von individualisierten, einzigartigen Produkten - war von Anfang an das Markenzeichen von Industrie 4.0.
Bei Busch-Jaeger in Lüdenscheid haben wir eine Produktionslinie aufgebaut, in der ein individualisiertes Endprodukt für die intelligente Raumsteuerung in der Gebäudeautomation versandfertig vom Band läuft. In weniger als einem Jahr wurden mehrere zehntausend Produkte nach individuellem Kundenauftrag gefertigt und ausgeliefert, und das Werk wurde mit dem Industrie 4.0 Award 2019 ausgezeichnet.
Im Hinblick auf die Anwendungsszenarien von Industrie 4.0 betreiben wir eine wandlungsfähige Fabrik, in der die Produktion auftragsgesteuert abläuft und tief in B2C- und B2B-Prozesse integriert ist, in der sich Materiallogistik selbst organisiert und in der menschliche Bediener leicht mit Maschinen interagieren können. Der Bau dieser Produktionslinie war nur durch einen fertigungsorientierten Front-End-Designprozess möglich, bei dem zunächst ein digitaler Zwilling der gesamten Produktionslinie in OPC UA definiert und erst dann die mechanische und elektrische Konstruktion gestartet wurde.
Um eine Fabrik auf diese Weise effizient zu gestalten, gibt es jedoch keine ausreichenden Standards und Werkzeuge für ein nahtloses digitales Engineering; plug-and-produce-fähige Maschinen können nicht einfach von der Stange bestellt werden; auch ist die Einhaltung höchster Qualitätsansprüche für einzigartige Produkte eine eigene Herausforderung. Darüber hinaus beginnen Kunden, eine Individualisierung zu fordern, die nicht allein durch Neukonfiguration bestehender Maschinenfähigkeiten erreicht werden kann, sondern die eine kontinuierliche Umgestaltung der laufenden Maschinen im Hinblick auf das erfordert, was wir eine " Evergreen Factory " nennen.
In diesem Papier stellen wir die Bausteine und besten Praktiken für die Planung, den Bau und den Betrieb einer solchen automatisierten Produktion in Losgröße Eins vor. Darüber hinaus zeigen wir die Lücken und Herausforderungen auf, mit denen Fabrikbetreiber, Maschinenbauer und Systemintegratoren gegen Ende des ersten Jahrzehnts von Industrie 4.0 noch immer konfrontiert werden. Wir schließen mit Erwartungen, wie diese Lücken geschlossen werden können, einschließlich der Rolle der Industrie 4.0 Verwaltungsschale.
Developing Islamic Suggestopedia-Based Classroom Management At Islamic Boarding Schools In Lampung Province
Authors: Et al. Muhamad Dini Handoko 
Published: May 2021

This research was conducted at a boarding school in Lampung. The research object consisted of three Islamic boarding schools: Al-Ismailiyun Islamic Boarding School, South Lampung, Darul 'Ulya Kota Metro Islamic Boarding School, and Riyadlatul ‘Ulum Islamic Boarding School, East Lampung. In general, this research aimed to analyze, validate, and test the effectiveness of class management in Islamic boarding schools in Lampung province. The approach applied in this research was development research using the ADDIE model. This research was a classroom management development research based on Islamic suggestopedia. The results revealed several important findings regarding classroom management in Islamic boarding schools in Lampung province. First is the condition of Class Management which has been applied in Islamic boarding schools. The second is the finding of a form of Islamic Suggestopedia-based Class Management which can increase the learning effectiveness at Islamic boarding schools in Lampung Province. The third is the result of implementing Islamic Suggestopedia-based Class Management which can increase the learning effectiveness at Islamic boarding schools in Lampung Province.
Students’ Understanding and Learning: Mediation Effects of Cognitive Engagement in Online Classes
Authors: Et al. Dr. C.Nagadeepa 
Published: May 2021

Beneath the perils of pandemic, this trend has moved very fast and in a professional manner to fill in the space produced as a result of suspended classroom learning. During this pandemic the educational institutions have been forced to adopt online learning without practicing it. As a consequence, there are several challenges to be encountered by the facilitator as well as learners to benefit from it. This paper is a descriptive study of e learning scenario among the learners of higher education in commerce deanery. This paper aims at finding out the factors which lead to student’s active engagement in the online classes. 1065 students from various colleges who had attended online classes in the last six months responded through a structured questionnaire and the data was analyzed to find out the students’ understanding and learning.
MACROADENOMA HIPOFISÁRIO SECRETOR DE ACTH EVOLUINDO COM DOENÇA DE CUSHING: RELATO DE CASO
Authors: Cavalcante Macedo Parente Thaís Mahassem 
Published: May 2021

Macroademomas hipofisários são tumores da adenohipófise maiores que 10 mm de diâmetro, podendo cursar com sintomas associados ao efeito de massa. São classificados como corticotropinomas quando hormonalmente ativos com secreção exacerbada de ACTH. Esse excesso de secreção de ACTH por um adenoma hipofisário causa a doença de Cushing. De maneira geral, o paciente queixa-se de cefaleia de forte intensidade, tonturas, seguido de síncopes, podendo evoluir com crises convulsivas e alguns episódios de confusão mental. O objetivo deste estudo é relatar o caso de um paciente de 30 anos, do sexo masculino, portador de macroadenoma hipofisário corticotrófico, que abriu um quadro raro com convulsões, evoluindo com sinais clínicos discretos de doença de Cushing, acompanhado no Hospital Geral Público de Palmas -TO, tratado com cetoconazol e com indicação de cirurgia transesfenoidal para ressecção do tumor.
Palavras-chave: Macroadenoma hipofisário. Convulsões. ACTH. Doença de Cushing. Cirurgia transesfenoidal.
Bernoulli-Assisted Percutaneous Removal of an Intra-articular Foreign Body
Authors: Keyes Sean , Morscher Melanie A. , Bono Kenneth T. 
Published: May 2021

Case:
A 4-year-old child presented with an intra-articular broken sewing needle in her knee. It was removed arthroscopically using a spinal needle percutaneously placed posterior to the tibia in line with the long axis of the sewing needle. The stylet was partially withdrawn to allow the sewing needle to lay within the spinal needle hollow. When the stylet was removed, the foreign body was propelled through the spinal needle by the increased velocity of the outflowing fluid and decreased pressure (Bernoulli's principle) and was caught in a specimen container.

Conclusion:
This percutaneous technique is one of several for removing a small foreign body.
.QSAR-QMMM Cryptographic Mining on Chern-Simons Topologies for the generation of a Ligand Targeting SARS-COV-2 D614G Binding Sites.
Authors: Grigoriadis Ioannis 
Published: May 2021

Abstract
SARS coronavirus 2 (SARS-CoV-2) in the viral spike (S) encoding a SARS-COV-2 SPIKE D614G mutation protein predominate over time in locales revealing the dynamic aspects of its key viral processes where it is found, implying that this change enhances viral transmission. It has also been observed that retroviruses infected ACE2-expressing cells pseudotyped with SG614 that is presently affecting a growing number of countries markedly more efficiently than those with SD614. In this paper, we strongly combine topology geometric methods targeting at the atomistic level the protein apparatus of the SARS-COV-2 virus that are simple in machine learning anti-viral characteristics, to propose computer-aided rational drug design strategies efficient in computing docking usage, and powerful enough to achieve very high accuracy levels for this in-silico effort for the generation of the AI-Quantum designed molecule of GisitorviffirnaTM, Roccustyrna_gs1_TM, and Roccustyrna_fr1_TM ligands with Preferred IUPAC Names of (7aR)‐5‐amino‐N‐[(S)‐ {2‐[(S)‐[(E)‐(amino methylidene)amino](cyano)methyl]hydrazin‐1‐yl} (aziridin‐1‐yl)phosphoryl]‐ 1‐[(2E)‐2‐ [(fluoromethanimidoyl) imino]acetyl]‐7‐oxo‐1H,7H,7aH‐pyrazolo[4,3‐d]pyrimidine‐3‐carboxamide; N‐{[(2‐ amino‐6‐oxo‐6,9‐dihydro‐1H‐purin‐9‐yl)amino]({1‐[5‐({[cyano({1‐[(diamino methylidene)amino] ethenyl})amino]oxy}methyl)‐3,4‐dihydroxyoxolan‐2‐yl]‐1H‐1,2,4‐triazol‐3‐yl}formamido)phosphoryl}‐6‐fluoro‐3,4‐dihydropyrazine‐2‐carboxamide;[3‐(2‐amino‐5‐sulfanylidene‐1,2,4‐triazolidin‐3‐yl)oxaziridin‐2‐yl]({3‐sulfanylidene‐1,2,4,6‐tetraazabicyclo[3.1.0]hexan‐6‐yl})phosphoroso1‐(3,4,5‐trifluorooxolan‐2‐yl)‐1H‐1,2,4‐triazole‐3‐carboxylate targeting the COVID-19-SARS-COV-2 SPIKE D614G mutation using Chern-Simons Topology Euclidean Geometric in a Lindenbaum-Tarski generated QSAR automating modeling and Artificial Intelligence-Driven Predictive Neural Networks.
Prognostic significance of preoperative NLR, PLR and LMR in patients suffering from gastric neuroendocrine tumor
Authors: Fang Can , Zou Bing-bing 
Published: May 2021

Abstract
Background: The prognostic value of inflammatory response makers for predicting clinical outcome have been proved valid in various cancers.The aim of this study was to explore the influence of the neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR)and lymphocyte-to-monocyte ratio(LMR) on the prognosis of gastric neuroendocrine tumor.Methods: One hundred and three patients who underwent curative surgery for gastric neuroendocrine tumor were enrolled form 2009-2018 in The first affiliated hospital of Anhui Medical University.NLR,PLR and LMR were calculated from peripheral blood cell counts taken before surgery.Optimal cutoff values of NLR,PLR and LMR were determined on the basis of receiver operating characteristic curve analysis,and their prognostic values were assessed using Kaplan-Meier curve,univariate and multivariate COX regression models.Result:The cutoff value of NLR,PLR and LMR was 2.08,147.5 and 3.94,respectively.Elevated NLR,PLR and declined LMR were found to relate with diminished Overall survival (OS) in surgical gNET patients.Multivariate analysis identified the LMR(HR=0.923 (0.860-0.991), P=0.027);tumor size(HR=1.130 (1.032-1.239),P = 0.009) and high grade postoperative complication(HR=2.847 (1.129-7.480), P =0.027) as independent prognostic factors.Conclusion: Inflammatory response markers can predict clinical outcome in patients with gNET,especially LMR might be considered as a convenient indicator for patients’ prognosis
Cancer and exposure to pesticides: a bibliometric study from the last 10 years
Authors: Pedroso Thays , Benvindo-Souza Marcelino , Nascimento Felipe , Woch Julia , Reis Fabiana dos , Silva Daniela de Melo e 
Published: May 2021

Abstract
Occupational exposure to pesticides has been identified as a promoting factor for the development of cancer. Pesticides can cause intoxication in the individuals who manipulate them, either by inhalation, ingestion, or dermal contact. Therefore, our study aimed to describe the association between cancer and occupational exposure to pesticides from 2011 to 2020 through a bibliometric analysis. We selected 62 papers in the Scopus database. The results indicated an exponential increase in studies in the last decade; on a geographic scale, the USA, France, India, and Brazil were the countries that most investigated the association of cancer and pesticides among the 21 nationalities found. The main classes of pesticides were insecticides, herbicides, and fungicides associated with intoxication and cancer. Among the most reported cancers were multiple myeloma, bladder cancer, non-Hodgkin’s lymphoma, prostate, leukemia, and breast cancer. Although pesticides are associated with health problems, studies involving cancer and these products are still scarce when related to global use and the demand for agricultural production on the planet.
Hypoxia-Related Immune Gene Signature Predicting Prognosis in Patients With Hepatocellular Carcinoma
Authors: Zhou Lingshan , Yang Yuan , Liu Min , Liu Rong , Ren Man , Zheng Ya , Wang Yuping , Zhou Yongning 
Published: May 2021

Abstract
BackgroundHepatocellular carcinoma (HCC) remains a global health challenge. Increasing evidence indicates that hypoxia is crucial in the evolution and progression of HCC by regulating the tumor immune microenvironment. The present study aimed to construct a prognostic relevant hypoxia-related immune gene (HRIG) signature. MethodsWe analyzed the expression profile of the 163 HRIGs and clinical information of 371 patients with HCC obtained from The Cancer Genome Atlas (TCGA). Then, consensus clustering analysis was performed to divide HCC patients into clusters 1 and 2 based on the HRIG expression. Subsequently, A multigene signature was constructed by Least absolute shrinkage and selection operator (LASSO) Cox regression analyses. Then, we evaluated the prognostic capability of this signature by Kaplan-Meier analysis, univariate Cox regression and multivariate Cox regression. The prognostic value of the signature was validated in the International Cancer Genome Consortium (ICGC) database. Furthermore, the functional enrichment analyses were preformed to elucidate their biological significance. Finally, we evaluated the infiltration of immune cells and the sensitivity of administrating chemotherapeutic agents.ResultsA total of 37 prognosis-related HRIGs were obtained. Subsequently, we constructed an 8-gene signature on the basis of prognosis-related HRIGs, which had a good performance in predicting the overall survival of patients with HCC. In addition, the signature expressed robust when validated in ICGC. The results revealed that these genes involved in some of the HCC-related pathways and was associated with the infiltration of immune cell subtypes. More importantly, the identified model was linked to the sensitivity of some chemotherapeutic agents. ConclusionsHRIG signature is an effective predictor for the prognosis of patients with HCC.
Influence Of Competition And Intraguild Predation Between Two Candidate Biocontrol Parasitoids On Their Potential Impact Against Harrisia Cactus Mealybug, Hypogeococcus sp. (Hemiptera: Pseudococcidae)
Authors: Aguirre María B. , Bruzzone Octavio A. , Triapitsyn Serguei V. , Diaz-Soltero Hilda , Hight Stephen D. , Logarzo Guillermo A. 
Published: May 2021

Abstract
When two or more parasitoid species, particularly candidates for biocontrol, share the same target in the same temporal window, a complex of behaviors can occur among them. We studied the type of interactions (competition and intraguild predation) that existed between the nymphal parasitoids Anagyrus cachamai and A. lapachosus (Hymenoptera: Encyrtidae), two candidate neoclassical biocontrol agents against the Puerto Rican cactus pest mealybug, Hypogeococcus sp. (Hemiptera: Pseudococcidae). The surrogate native congener host in Argentina, the cactus mealybug Hypogeococcus sp., was studied to predict which species should be released; in the case that both should be released, in which order, and their potential impact on host suppression. In the laboratory we conducted experiments where different densities of the host mealybug were exposed to naive females of A. cachamai and A. lapachosus sequentially in both directions. Experiments were analyzed by combining a series of competitive behavioral and functional response models. A fully Bayesian approach was used to select the best explaining models and calculate their parameters. Intraguild predation existed between A. cachamai, the species that had the greatest ability to exploit the resource, and A. lapachosus, the strongest species in the interference competition. The role that intraguild predation played in suppression of Hypogeococcus sp. indicated that a multiple release strategy for the two biocontrol agents would produce better control than a single release; as for the release order, A. lapachosus should be released first.
Bacterial Strain for Bast Fiber Crops Degumming and Its Bio-Degumming Technique
Authors: Duan Shengwen , Xu Bingrong , Cheng Lifeng , Feng Xiangyuan , Yang Qi , Zheng Ke , Gao Mingqiang , Peng Yuande 
Published: May 2021

Abstract
The R&D of bio-degumming technology is under a slow progress due to the shortage of proper efficient bacterial strains and processes. A degumming bacterial strain—Pectobacterium wasabiae (PW)—with broad-spectrum degumming abilities was screened out in this study. After the fermentation for 12 h, the residual gum contents of kenaf bast, ramie bast, hemp bast, flax bast, and Apocynum venetum bast were all lower than 15%. This bacterial strain could realize the simultaneous extracellular secretion of pectinase, mannase, and xylanase with the maximum enzyme activity levels of 130.25, 157.58, and 115.24 IU/mL, respectively. The optimal degumming conditions of this bacterial strain were as follows: degumming time of 12 h, bath ratio of 1:10, temperature of 33 ℃, and inoculum size of 2%. After the bio-degumming through this bacterial strain, the COD in wastewater was below 4,000 mg/L, which was over 60% lower than that in boiling-off wastewater generated by chemical degumming. This technology achieves higher efficiency, higher quality, and lower pollution.
Systematic Pan-Cancer Analysis and Experimental Verification Identify FOXA1 As An Immunological and Prognostic Biomarker In Epithelial Ovarian Cancer
Authors: Wang Kai , Yu Junhui , Guan Chenan , Chen Xing , Shang Xianwen , Mei Shuangshuang , Feng Xingjun , Zheng Lingzhi 
Published: May 2021

Abstract
Background: Epithelial ovarian cancer (EOC) has the lowest survival rate among female reproductive cancers present with symptoms of aggressive malignancies, poor prognosis, drug resistance and postoperative recurrence. The majority of patients with EOC are diagnosed at an advanced stage due to the therapeutic challenges including lack of early diagnosis and effective therapeutic targets for EOC.Methods: Pan-cancer analyses were performed to explore the features of Forkhead box (FOX) A1 (FOXA1) using data from TCGA and GTEx database. R package “clusterprofiler” was used to perform the enrichment analysis of FOXA1 in EOC. Data downloaded from Drug Sensitivity in Cancer (GDSC) database were used to evaluate the association between FOXA1 and anti-tumor drug sensitivity. In experimental verification, FOXA1 expression was detected using qRT-PCR and Western blot assays. Western blot, immunofluorescence staining and transwell assays were used to assess the influence of FOXA1 silencing on epithelial-mesenchymal transition (EMT) of EOC cellsResults: We found that FOXA1 was highly expressed in EOC and predicted poorer survival of EOC patients. We observed that FOXA1 expression was positively correlated EMT related pathways. Through experimental verification, we found the underlying function of FOXA1 to promote EMT in ovarian cancers. Results from western blot, immunofluorescence staining and transwell assays showed that FOXA1 silencing impeded the progression of EMT and invasiveness of the cancer cells. Furthermore, CCK-8 and invasion assays suggested that siRNA-FOXA1 attenuated the ability of cancer cells to metastasize and proliferate. Dual-luciferase reporter assays confirmed the binding activity of FOXA1 to the promoter of connective tissue growth factor (CTGF). In addition, we found that FOXA1 was closely correlated immunosuppressive microenvironment of EOC. High FOXA1 expression may contribute to resistance of many anti-cancer drugs.Conclusions: Our results predict and validate the function of FOXA1 in promoting EMT and the progression of disease in EOC. Targeting FOXA1 may improve the sensitivity of EOC treatment.
Impact of Land Use On The Variability of Soil Attributes Within Distinct Amazonian Environments
Authors: de Aquino Renato Eleotério , Júnior José Marques , Campos Milton César Costa , Silva Laércio Santos , Gomes Romário Pimenta , Pimentel Marcelo Laranjeira , de Oliveira Ivanildo Amorim , Siqueira Diego Silva 
Published: May 2021

Abstract
Changes in soil attributes caused by the conversion of native forest for agricultural use in the Amazon region is an area of research because of current uncertainties regarding land use and occupation processes. These uncertainties are significant for tropical soils. Understanding changes in soil attributes is vital for developing strategies to mitigate greenhouse gas emissions in the Amazon region. The objective of this study was to investigate the impact of land use on soil attribute variability occurring in distinctly Amazonian environments. This study was conducted using five meshes in Southern Amazonas: Forest 1, cassava, sugarcane, Forest 2, and Archeological Dark Earth (ADE). Descriptive statistical, geostatistical, and multivariate analyses were performed on data obtained from local measurements of CO2 emissions and data obtained from physical and chemical analysis of soil layers up to a depth of 20 cm. Most physical, chemical, and biological attributes of the soil were related to land use classifications. The similarity between cultivated and forested areas yielded no evidence of land degradation resulting from land use. Increasing certain physical attributes total porosity (PT), soil moisture (SM), and Macroporosity (Macro) yielded a greater increase in the CO2 efflux for ADE and Amazon forest environments than for cultivated regions.
Anti-quorum Sensing Potential of Ageratum Conyzoides L. (Asteraceae) Extracts
Authors: COMPAORE Eli , COMPAORE Moussa , OUEDRAOGO Vincent , ROUAMBA Ablassé , KIENDREBEOGO Martin 
Published: May 2021

Abstract
Background: Pseudomonas aeruginosa causes infections in human particularly immunocompromised patients with cystic fibrosis, severe burns and HIV, resulting in high morbidity and mortality. The pathogenic bacteria P aeruginosa produces virulence factors regulated by the mechanism called quorum sensing system. Objective: The aim of this study was to assess the anti-quorum sensing activity of Ageratum conyzoides extracts Method: Chromobacterium violaceum reporter strain CV026 was used to highlight any interference with bacterium QS and strains derived from P. aeruginosa PAO1 were used to reveal any interference with the expression of quorum sensing genes, and to assess any impact of extract on the kinetics of the production of pyocyanin, elastases and biofilm formation. Results: Hydro-methanolic extract at the sub-inhibitory concentration of 100 μg/mL reduced quorum sensing virulence factors production such as, pyocyanin, elastases, rhamnolipids and biofilm formation in P. aeruginosa PAO1 after 18 hours monitoring. Extract showed significant inhibition in HSL-mediated violacein production on C. violaceum CV026 after 48 hours monitoring. Biofilm formation was inhibited up to 32%. It affected QS gene expression in PAO1. The regulatory genes lasR / rhlR and the lasI synthases were most affected. At 8hours, hydro-methanolic extract reduced both QS gene to more than 30% (lasI/lasR and rhlI/R respectively 33.8% /30.2% and 36% /33.2%). RhlA and lasB genes have been relatively affected (13.4% and 28.9%). After 18 h, this extract reduced significantly the expression of regulatory 30 genes lasR (31%) and rhlR (39.6%) although synthases genes seemed to be less affected (lasI/21.2% and rhlI/11.6%). A limited impact was observed on the downstream genes (lasB /20.0% and rhlA /15.3%). No negative impact was observed on CV026 and PAO1 growth and cell viability. Our study also showed that A. conyzoides having ample amount of phenolics, flavonoids and triterpenoids. This phytochemical content could be one of the factors for showing anti quorum potential. Conclusion: Results indicate that hydro methanol 80 % extract from A. conyzoides could be a source of potential QS inhibition compounds.