bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECTIVENESS OF BUNDO PEDULI JENTIK PROGRAM IN CONTROLLING THE DENGUE HEMORRHAGIC FEVER
Authors: Anggraini Wike , Arwanto Arwanto , Danda Saskia Pratiwi 
Published: September 2021

Abstract
Dengue Hemorrhagic Fever(DHF) was the deadliest disease in Indonesia with the highest number of cases in 2016. This study aims to determine the effectiveness of Bundo Peduli Jentik program, one of the Health Department of Padang City Government programs, in controlling DHF, especially in Lubuk Kilangan Sub-district. This is a descriptive qualitative research with an inductive approach. Data and information collection were done by observation, interviews and documentation. The theory used is the theory of effectiveness proposed by Budiani that measures effectiveness comprising the accuracy of program targets, program socialization, program objectives and program monitoring. The result showed that the Bundo Peduli Jentik program has been categorized as effective based on the theory used. This is proven by the DHF cases continue to decline every year and there were no number of deaths due to DHF since 2017 in Lubuk Kilangan, Padang City.

Keywords: Dengue Hemorrhagic Fever, Effectiveness, Government Program

Abstrak
Demam Berdarah Dengue (DBD) pernah menjadi penyakit paling mematikan di Indonesia dengan jumlah kasus terbanyak di tahun 2016. Penelitian ini bertujuan untuk mengetahui efektivitas program Bundo Peduli Jentik, salah satu program Dinas Kesehatan Pemerintah Kota Padang, dalam pengendalian DBD terutama di Kecamatan Lubuk Kilangan. Metode penelitian dalam penelitian ini adalah metode kualitatif deskriptif dengan pendekatan induktif. Pengumpulan data dan informasi dilakukan dengan cara observasi, wawancara dan dokumentasi. Teori yang digunakan dalam penelitian ini adalah teori efektivitas yang dikemukakan oleh Budiani yang mengukur efektivitas menggunakan variabel-variabel, diantaranya ketepatan sasaran program, sosialisasi program, tujuan program dan pemantauan program. Hasil penelitian menunjukkan bahwa program Bundo Peduli Jentik dapat dikategorikan efektif berdasarkan teori yang digunakan. Hal ini dibuktikan dengan kasus DBD yang terus menurun setiap tahunnya bahkan tidak ada lagi kasus kematian karena DBD sejak tahun 2017 di Kecamatan Lubuk Kilangan, Kota Padang.

Kata Kunci: Demam Berdarah Dengue, Efektivitas, Program Pemerintah
DEWAN PERWAKILAN DAERAH DAN AKTUALISASI HUBUNGAN PUSAT-DAERAH
Authors: Kuddus Baharuddin Thahir 
Published: September 2021

Distribusi kekuasaan pada sebuah Negara dapat dilihat dari dua hal, yaitu distribusi kekuasaan secara vertical dan distribusi kekuasaan secara vertical. Distribusi kekuasaan secara vertical dapat dilihat dalam pelaksanaan desentralisasi melalui otonomi daerah sementara distribusi kekuasaan dapat dilihat pada eksistensi dan hubungan antara lembaga-lembaga Negara. Kebijakan desentralisasi didasarkan pada kenyataan bahwa keadaan geografis dan demografis Indonesia (conditiosine qua non). Dalam pelaksanaan desentralisasi, hubungan pusat dan daerah seringkali melahirkan konflik. Hal itu berkenaan dengan derajat otonomi daerah dan pada saat yang sama kadar keterlibatan pusat dalam pelaksanaan fungsi pemerintahan di daerah. Hal itu berarti terdapat dua kepentingan yang harus dipertimbangkan supaya tatanan sistem pemerintahan daerah dapat berjalan dengan optimal dan memenuhi amanat konstitusi.
Sementara itu dalam sistem ketatanegaraan Indonesia, Dewan Perwakilan Daerah ditempatkan sebagai salah satu unsur lembaga legislatif, disamping lembaga Dewan Perwakilan Rakyat. DPD mestinya menjadi penting antara lain disebabkan posisinya yang sangat strategis dalam melakukan pengawasan terhadap pelaksanaan peraturan perundang-undangan dan pelaksanaan kebijakan pemerintah. Dalam konteks distribusi kekuasaan secara horizontal itu pula maka Dewan Perwakilan Daerah diadakan untuk check and balances. DPD menjadi instrument kelembagaan yang semakin menghadirkan aspirasi daerah di level pusat dan menjadikan hubungan pusat dan daerah semakin erat dan bersinergi dalam menjalankan roda pemerintahan.
ANALISIS IMPLEMENTASI KEBIJAKAN PEMBENTUKAN DAERAH OTONOM BARU (DOB) PROVINSI PAPUA TENGAH
Authors: Cahyadi M Fikri , Kurniawan Teguh 
Published: September 2021

DOB dapat meningkatkan pelayanan publik dan mewujudkan efektivitas penyelenggaraan pemerintahan di daerah. Parameter yang digunakan melalui Rasio SDM Aparatur, Ekonomi, Pendidikan, Kesehatan, Kependudukan dan Fiskal Daerah menjadi tolak ukur bahwa pembentukan DOB dalam meningkatkan pelayanan publik sudah dapat direalisasikan. Penulisan ini menggunakan pendekatan kualitatif dengan metode pengumpulan data studi literatur (literatur reviu) melalui dokumentasi terkait dengan penelitian dalam bentuk Kajian Strategis, Tesis dan Disertasi tentang Pembentukan DOB, serta melalui peraturan perundang-undangan yang berkaitan dengan penelitian. Hasil penulisan menunjukkan bahwa sinergitas dalam pembinaan, pendampingan serta upaya peningkatan pelayanan kepada masyarakat dalam penyelenggaraan DOB menuju daerah otonom maju dan mandiri dapat diukur melalui parameter yang untuk mencapai sasaran yang ditetapkan dalam pelayanan kepada masyarakat.
Kata Kunci: Daerah Otonom, DOB, Pelayanan Publik, Pemerintahan Daerah
MENINGKATKAN KETERAMPILAN MENGOPERASIKAN PERALATAN EKSTRAKSI MELALUI MODEL PEMBELAJARAN POE (PREDICT, OBSERVE, EXPLAIN)
Authors: Siti Nurjanna  
Published: September 2021

This study aims to enhance the skills of students to operate extraction equipment. This is a two-cycle Classroom Action Search. The focus of the research was students in class XI E, which consisted of 15 people. The data-gathering technique uses non-test instrument. The data analysis technique used qualitative analysis. The results showed an increase in the skills of the extraction equipment. Completeness of learning cycle I was 66.67% and increased to 93.33%. Meanwhile, the average score of students' skills increased from 74.63 in the first cycle to 80.39 in the second cycle, with value of Asymp.Sig.(2-tailed) 0.005 < 0.05, which means that there is a significant difference between the average class value in cycle I and the average class value in cycle II. Ignorance that the POE learning model can improve skills to operate extraction equipment.
Penelitian ini bertujuan untuk meningkatkan keterampilan mengoperasikan peralatan ekstraksi. Penelitian ini merupakan Penelitian Tindakan Kelas dengan 2 siklus. Obyek penelitian adalah siswa kelas XI E yang berjumlah 15 orang. Teknik pengumpulan data berupa instrumen non tes. Teknik analisis data menggunakan analisis kualitatif. Hasil penelitian menunjukkan terjadi peningkatan keterampilan mengoperasikan peralatan ekstraksi. Ketuntasan belajar siklus I sebesar 66,67% meningkat menjadi 93,33%. Sedangkan rata-rata nilai keterampilan siswa meningkat dari 74,63 pada siklus I menjadi 80,39 pada siklus II, dengan nilai Asymp.Sig.(2-tailed) 0,005 < 0,05, berarti terdapat perbedaan yang signifikan antara rata-rata nilai siklus I dengan rata-rata nilai siklus II. Disimpulkan bahwa penerapan model pembelajaran POE dapat meningkatkan keterampilan mengoperasikan peralatan ekstraksi.
Identification and Validation of a Nine-Gene Amino Acid Metabolism-Related Risk Signature in HCC
Authors: Zhao Yajuan , Zhang Junli , Wang Shuhan , Jiang Qianqian , Xu Keshu 
Published: September 2021

Background: Hepatocellular carcinoma (HCC) is the world’s second most deadly cancer, and metabolic reprogramming is its distinguishing feature. Among metabolite profiling, variation in amino acid metabolism supports tumor proliferation and metastasis to the most extent, yet a systematic study on the role of amino acid metabolism-related genes in HCC is still lacking. An effective amino acid metabolism-related prediction signature is urgently needed to assess the prognosis of HCC patients for individualized treatment.Materials and Methods: RNA-seq data of HCC from the TCGA-LIHC and GSE14520 (GPL3921) datasets were defined as the training set and validation set, respectively. Amino acid metabolic genes were extracted from the Molecular Signature Database. Univariate Cox and LASSO regression analyses were performed to build a predictive risk signature. K-M curves, ROC curves, and univariate and multivariate Cox regression were conducted to evaluate the predictive value of this risk signature. Functional enrichment was analyzed by GSEA and CIBERSORTx software.Results: A nine-gene amino acid metabolism-related risk signature including B3GAT3, B4GALT2, CYB5R3, GNPDA1, GOT2, HEXB, HMGCS2, PLOD2, and SEPHS1 was constructed to predict the overall survival (OS) of HCC patients. Patients were separated into high-risk and low-risk groups based on risk scores and low-risk patients had lower risk scores and longer survival time. Univariate and multivariate Cox regression verified that this signature was an independent risk factor for HCC. ROC curves showed that this risk signature can effectively predict the 1-, 2-, 3- and 5-year survival times of patients with HCC. Additionally, prognostic nomograms were established based on the training set and validation set. These genes were closely correlated with the immune regulation.Conclusion: Our study identified a nine-gene amino acid metabolism-related risk signature and built predictive nomograms for OS in HCC. These findings will help us to personalize the treatment of liver cancer patients.
Recall and Understanding of Discharge Information in Observation Ward Patients: An Explorative Observational Study
Authors: Østen Kjersti , Menichetti Julia , Nordfalk Jenny M. , Ofstad Eirik H. 
Published: September 2021

Effective communication is essential for understanding and recall of hospital discharge information. This study aimed to explore discharge information, patient recall and patient involvement in discharge encounters. We conducted an explorative observational study at a secondary care level, observational ward. Patients discharged to their home were asked to participate. 34 patients were assessed for eligibility, of which 13 were included in the analysis. Multiple sources of data were collected: videotapes of discharge encounters, questionnaires to patients and physicians, and semi-structured interviews with patients 2 weeks after discharge. All patients were satisfied with the information received. Five of the eight patients discharged with more than one change in medication had only partial or no recall of these changes. In seven of the 13 encounters the patients and physicians did not agree on the main message most important information item. The patients were to a small extent involved in decision-making. Our findings highlight the gaps in the information exchange at discharge encounters and the resulting poor information recall among patients. Patients do not seem aware of these gaps. Greater provider awareness of patient involvement in the encounter and inclusion of the patient’s perspective may improve communication, and consequently understanding and recall.
Central Systolic Blood Pressure Is Associated With Early Vascular Damage in Children and Adolescents With Type 1 Diabetes
Authors: Tagetti Angela , Piona Claudia A. , Marcon Denise , Giontella Alice , Branz Lorella , Bortolotti Stefano , Morandi Anita , Maffeis Claudio , Fava Cristiano 
Published: September 2021

Objective of the study: This study aimed to test the effect of multiple cardiovascular risk factors on subclinical indices of atherosclerosis in children and adolescents with type 1 diabetes (T1D).Methods: Carotid intima-media thickness (cIMT), carotid distensibility coefficient (cDC), and carotid–femoral pulse wave velocity (PWV) were measured in children and adolescents with T1D, in a follow-up at the outpatient clinics of Verona. Blood pressure (BP; both central and peripheral), metabolic and other cardiovascular risk factors were evaluated in multivariate linear regressions to assess the association with the measured indices of subclinical vascular damage.Results: One hundred and twenty-six children and adolescents were included. cIMT was above the 95th percentile for age and height in 60.8% of the population, whereas 26% of the sample had cDC impairment (less than the 5th percentile) and 4.8% had an elevated PWV. Independent determinants of cIMT according to the regression models were only gender type of glucose monitoring and central systolic BP (cSBP). PWV was associated with age, sex, heart rate, and cSBP; cDC with age and both cSBP and, alternatively, peripheral BP (pBP). Neither pBP nor any of the tested metabolic parameters, including glycated hemoglobin, was associated with PWV and cIMT.Conclusions: A high proportion of early vascular damage, especially an increased cIMT, is present in children and adolescents with T1D in whom cSBP seems to be a common determinant. In children and adolescents with T1DM, a special focus should be on hemodynamic risk factors beyond metabolic ones.
Safety and Efficacy Using the Second-Generation Cryoballoon in Patients With Atrial Fibrillation and a Common Ostium of Inferior Pulmonary Veins
Authors: Xie Hai-yang , Guo Xiao-gang , Yang Jian-du , Li Jia-hui , Chen Yan-qiao , Cao Zhong-jing , Sun Qi , Li Xiao-yao , Ma Jian 
Published: September 2021

Background: Common ostium of inferior pulmonary veins (COIPV) is a kind of pulmonary vein variation. The safety and efficacy of COIPV isolation using the second-generation cryoballoon (CB) ablation remain unknown.Methods: A total of 10 patients with COIPV from a consecutive series of 1,751 patients with atrial fibrillation (AF) were included. Pulmonary vein isolation (PVI) was performed using the second-generation CB.Results: The prevalence of a COIPV was 0.57% in this study. PVI was achieved in all pulmonary veins (PVs) without the need for a touch-up. A segmental freeze strategy was applied for each inferior PV, respectively. The mean number of freeze cycles of inferior PVs was 1.4 ± 0.5 for the left inferior pulmonary vein (LIPV), and 2.0 ± 0.9 for the right inferior pulmonary vein (RIPV). Pulmonary vein potential (PVP) of RIPV could not be monitored in real-time in three cases. Eight of 10 patients (80%) were free from atrial arrhythmias without the use of antiarrhythmic drugs during a follow-up period of 23.6 ± 12.9 months. No procedure-related complications occurred in any of the 10 patients.Conclusions: Common ostium of inferior pulmonary veins is a rare but challenging PV variant. PVI with this unusual anatomic variation using the second-generation 28-mm CB is effective and safe.
Six-Year Follow-Up Outcomes of Catheter Ablation of Para-Hisian Accessory Pathways
Authors: Chen Qingxing , Xu Lili , Zou Tian , Cheng Kuang , Ling Yunlong , Xu Ye , Pang Yang , Liu Guijian , Zhu Wenqing , Ge Junbo 
Published: September 2021

Background: Ablation of para-hisian accessory pathways (APs) remains challenging due to anatomic characteristics, and a few studies have focused on the causes for recurrence of radiofrequency ablation of para-hisian APs.Objective: This retrospective single center study aimed to explore the risk factors for recurrence of para-hisian APs.Methods: One hundred thirteen patients who had para-hisian AP with an acute success were enrolled in the study. In the 6-year follow-up, 15 cases had a recurrent para-hisian AP. Therefore, 98 patients were classified into the success group, while 15 patients were classified into the recurrence group. Demographic and ablation characteristics were analyzed.Results: Gender difference was similar in two groups. The median age was 36.2 years old and was younger in the recurrence group. Maximum ablation power was significantly higher in the success group (29 ± 7.5 vs. 22.9 ± 7.8, p &lt; 0.01). Ablation time of final target sites was found to be markedly higher in the success group (123.4 ± 53.1 vs. 86.7 ± 58.3, p &lt; 0.05). Ablation time &lt;60 s was detected in 12 (12.2%) cases in the success group and 7 (46.7%) cases in the recurrence group (p &lt; 0.01). Occurrence of junctional rhythm was significantly higher in the recurrence group (25.5% vs. 53.3%, p &lt; 0.05). No severe conduction block, no pacemaker implantation, and no stroke were reported. Junctional rhythm during ablation (OR = 3.833, 95% CI 1.083–13.572, p = 0.037) and ablation time &lt;60 s (OR = 5.487, 95% CI 1.411–21.340, p = 0.014) were independent risk factors for the recurrence of para-hisian AP.Conclusions: With careful and accurate mapping, it is relatively safe to ablate para-hisian AP. If possible, proper extension of ablation time could reduce the recurrence rate of para-hisian APs.
Brain-Derived Neurotrophic Factor Mitigates the Association Between Platelet Dysfunction and Cognitive Impairment
Authors: Bélanger Jean-Christophe , Bouchard Véronique , Le Blanc Jessica , Starnino Louisia , Welman Mélanie , Chabot-Blanchet Malorie , Busseuil David , Chertkow Howard , D'Antono Bianca , Lordkipanidzé Marie 
Published: September 2021

Background: Platelet hyperactivity is deleterious in coronary artery disease (CAD), requiring lifelong antiplatelet therapy, and is associated with worse cognitive outcomes. Upon activation, platelets release Brain-Derived Neurotrophic Factor (BDNF), a neurotrophin protective against cognitive decline. Given these apparently opposing effects of platelet activation on cognitive health, we investigated whether BDNF levels intercede in the relationship between platelet activation and cognitive function; and whether this relationship is moderated by the presence of CAD.Methods: In this cross-sectional study, 1,280 participants with (n = 673) and without CAD (n = 607) completed the Montreal Cognitive Assessment (MoCA). Plasma BDNF and soluble P-selectin (a marker of platelet activity) levels were assessed using multiplex flow cytometry.Results: In a mediation model, platelet activity was correlated with higher plasma BDNF concentrations (b = 0.53, p &lt; 0.0001). The relationship between sP-selectin and BDNF concentrations was stronger for individuals without CAD (b = 0.71, p &lt; 0.0001) than for CAD participants (b = 0.43, p &lt; 0.0001; pinteraction &lt;0.0001). Higher BDNF concentrations were associated with higher MoCA scores (b = 0.26, p = 0.03). The overall effect of platelet activity on cognitive performance was non-significant (total effect: b = −0.12, p = 0.13), and became significant when accounting for BDNF as a mediating factor (direct effect: b = −0.26, p = 0.01). This resulted in a positive indirect effect of platelet activity (via BDNF) on MoCA scores (b = 0.14, CI 95% 0.02–0.30), that was smaller in CAD participants than in non-CAD participants [Δ −0.07 (95% CI −0.14 to −0.01)].Conclusions: BDNF released from activated platelets could be a mitigating factor in a negative association between platelet activity and cognitive function.
Genesis of the Heiyanshan Tungsten Skarn Deposit in the East Tianshan, NW China: Insights From Geology, Fluid Inclusion, Isotopic Geochemistry and Geochronology
Authors: Xue Dong , Deng Xiao-Hua , Bagas Leon , Chen Xu-An , Wu Yan-Shuang , Jiang Xiao 
Published: September 2021

The eastern Tianshan Terrane is a highly prospective zone that contains several porphyry Cu–Mo, VMS Cu–Zn, magmatic Cu–Ni, epithermal and orogenic Au deposits. However, few attention has been paid to tungsten deposits. Of these, the source and evolution of the mineralising fluids related to the skarn W deposits are poorly understood. The Heiyanshan W deposit is hosted by metamorphosed clastic and carbonate beds in the Mesoproterozoic Jianshanzi Formation deposited on a continental margin tectonic setting. The Jianshanzi Formation is intruded by biotite monzogranite that yield weighted206Pb/238U age of 326.9 ± 1.6 Ma, which suggest that the Heiyanshan W deposit was formed in the Carboniferous. The mineralisation is hosted by a prograde hydrothermal altered zone represented by a garnet (–pyroxene) skarn, and retrograde skarn characterised by fine-grained scheelite. The paragenesis of the Heiyanshan mineralisation can be subdivided into prograde skarn stage, retrograde skarn stage, quartz-sulphide stage and quartz-calcite vein stage. The types of fluid inclusions recognised in the various minerals in the deposits are liquid-rich aqueous, vapour-rich aqueous, and daughter mineral-bearing. The homogenisation temperatures of fluid inclusions from the Heiyanshan deposit decrease from 290 ± 28°C in garnet, through 232 ± 31°C in scheelite, to 232 ± 36°C in quartz and 158 ± 15°C in non-mineralised calcite, which is typical of W-bearing skarn deposits worldwide. The δ18Owatervalues from the Heiyanshan deposit range from +4.7 to +6.6‰ in garnet, +1.3 to +1.9‰ in quartz and −6.1 to −4.4‰ in calcite. We have measured δD in fluid inclusions from different minerals, although these bulk analyses are just a mixture of the different FIA’s present in the sample. The δD values of fluid inclusions in garnet, quartz, and calcite are from −121 to −71‰, −84 to −75‰ and −101 to −82‰, respectively, also indicative of deep-sourced magmatic fluids mixed with meteoric water. The decrease in the homogenisation temperatures for the fluid inclusions at the Heiyanshan deposit is accompanied by a drop in salinity indicating that tungsten-bearing minerals precipitated during fluid mixing between magmatic fluids and meteoric water. We conclude that eastern Tianshan Terrane contains two pulse of tungsten metallogenic events of Late Carboniferous and Early Triassic.
Integrated Analysis of Prognostic Genes Associated With Ischemia–Reperfusion Injury in Renal Transplantation
Authors: Zhang Di , Wang Yicun , Zeng Song , Zhang Min , Zhang Xin , Wang Yuxuan , Zhang Zijian , Wang Xi , Hu Xiaopeng 
Published: September 2021

BackgroundIschemia–reperfusion injury (IRI) remains an inevitable and major challenge in renal transplantation. The current study aims to obtain deep insights into underlying mechanisms and seek prognostic genes as potential therapeutic targets for renal IRI (RIRI).MethodsAfter systematically screening the Gene Expression Omnibus (GEO) database, we collected gene expression profiles of over 1,000 specimens from 11 independent cohorts. Differentially expressed genes (DEGs) were identified by comparing allograft kidney biopsies taken before and after reperfusion in the discovery cohort and further validated in another two independent transplant cohorts. Then, graft survival analysis and immune cell analysis of DEGs were performed in another independent renal transplant cohort with long-term follow-ups to further screen out prognostic genes. Cell type and time course analyses were performed for investigating the expression pattern of prognostic genes in more dimensions utilizing a mouse RIRI model. Finally, two novel genes firstly identified in RIRI were verified in the mouse model and comprehensively analyzed to investigate potential mechanisms.ResultsTwenty DEGs upregulated in the process of RIRI throughout different donor types (living donors, cardiac and brain death donors) were successfully identified and validated. Among them, upregulation of 10 genes was associated with poor long-term allograft outcomes and exhibited strong correlations with prognostic immune cells, like macrophages. Furthermore, certain genes were found to be only differentially expressed in specific cell types and remained with high expression levels even months after RIRI in the mouse model, which processed the potential to serve as therapeutic targets. Importantly, two newly identified genes in RIRI, Btg2 and Rhob, were successfully confirmed in the mouse model and found to have strong connections with NF-κB signaling.ConclusionsWe successfully identified and validated 10 IRI-associated prognostic genes in renal transplantation across different donor types, and two novel genes with crucial roles in RIRI were recognized for the first time. Our findings offered promising potential therapeutic targets for RIRI in renal transplantation.