bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forecasting the 2020 COVID-19 Epidemic: A Multivariate Quasi-Poisson Regression to Model the Evolution of New Cases in Chile
Authors: Vicuña María Ignacia , Vásquez Cristián , Quiroga Bernardo F. 
Published: April 2021

Objectives:To understand and forecast the evolution of COVID-19 (Coronavirus disease 2019) in Chile, and analyze alternative simulated scenarios to better predict alternative paths, in order to implement policy solutions to stop the spread and minimize damage.Methods:We have specified a novel multi-parameter generalized logistic growth model, which does not only look at the trend of the data, but also includes explanatory covariates, using a quasi-Poisson regression specification to account for overdispersion of the count data. We fitted our model to data from the onset of the disease (February 28) until September 15. Estimating the parameters from our model, we predicted the growth of the epidemic for the evolution of the disease until the end of October 2020. We also evaluated via simulations different fictional scenarios for the outcome of alternative policies (those analyses are included in theSupplementary Material).Results and Conclusions:The evolution of the disease has not followed an exponential growth, but rather, stabilized and moved downward after July 2020, starting to increase again after the implementation of theStep-by-Steppolicy. The lockdown policy implemented in the majority of the country has proven effective in stopping the spread, and the lockdown-relaxation policies, however gradual, appear to have caused an upward break in the trend.
RETRACTED: Effects of Gallotannin-Enriched Extract of Galla Rhois on the Activation of Apoptosis, Cell Cycle Arrest, and Inhibition of Migration Ability in LLC1 Cells and LLC1 Tumors
Authors: Kang Mi Ju , Kim Ji Eun , Park Ji Won , Choi Hyun Jun , Bae Su Ji , Choi Sun Il , Hong Jin Tae , Hwang Dae Youn 
Published: April 2021

Gallotannin (GT) and GT-enriched extracts derived from various sources are reported to have anti-tumor activity in esophageal, colon and prostate tumors, although their anti-tumor effects have not been determined in lung carcinomas. To investigate the anti-tumor activity of GT-enriched extract of galla rhois (GEGR) against lung carcinomas, alterations in the cytotoxicity, apoptosis activation, cell cycle progression, migration ability, tumor growth, histopathological structure, and the regulation of signaling pathways were analyzed in Lewis lung carcinoma (LLC1) cells and LLC1 tumor bearing C57BL/6NKorl mice, after exposure to GEGR. A high concentration of GT (69%) and DPPH scavenging activity (IC50=7.922 µg/ml) was obtained in GEGR. GEGR treatment exerted strong cytotoxicity, cell cycle arrest at the G2/M phase and subsequent activation of apoptosis, as well as inhibitory effects on the MAPK pathway and PI3K/AKT mediated cell migration in LLC1 cells. In the in vivo syngeneic model, exposure to GEGR resulted in suppressed growth of the LLC1 tumors, as well as inhibition of NF-κB signaling and their inflammatory cytokines. Taken together, our results provide novel evidence that exposure to GEGR induces activation of apoptosis, cell cycle arrest, and inhibition of cell migration via suppression of the MAPK, NF-κB and PI3K/AKT signaling pathways in LLC1 cells and the LLC1 syngeneic model.
Konservasi Alam Berbasis Kearifan Lokal Suku Kokoda di Kepulauan Ugar, Kabupaten Fakfak, Papua Barat
Authors: Saputra Reza 
Published: April 2021

(Article History: Received 8 October 2020; Revised 2 November 2020; Accepted 10 November 2020) ABSTRAKPenelitian eksplorasi mengenai konservasi berbasis kearifan lokal Suku Kokoda di Kepulauan Ugar, Kabupaten Fakfak, Papua Barat telah dilaksanakan pada bulan Mei 2016. Tujuan penelitian ini untuk mengetahui peran jenis kearifan lokal terhadap alam sebagai penyangga kehidupan masyarakat Suku Kokoda. Aspek penelitian yang diamati yaitu kearifan lokal yang berdampak pada konservasi tingkat spesies atau ekosistem. Data yang didapat berasal dari wawancara semistruktural kepada 10 informan kunci. Pada penelitian ini terdapat tiga kearifan lokal yang teramati, yaitu sasi laut, hutan keramat, dan apotik hidup. Hasil penelitian menunjukan kearifan lokal yang ada pada suku Kokoda berperan penting dalam kelestarian alam di wilayah tersebut. Kata kunci: Kearifan lokal; Konservasi; Papua Barat; Suku Kokoda ABSTRACTExploration research on the local wisdom-based conservation of the Kokoda Tribe in the Ugar Islands, Fakfak Regency, West Papua, was conducted in May 2016. This research aimed to determine the role of Kokoda Tribe's local wisdom in preserving nature. The research aspect observed was local wisdom, which impacted conservation at the species or ecosystem level. The data obtained from semi-structured interviews of 10 key informants. In this research, three local wisdoms were observed, i.e. sasi laut, hutan keramat, and apotik hidup. The results show that the local wisdom of the Kokoda tribe plays an essential role in preserving nature.Keywords: Local Wisdom; Conservation; West Papua; Kokoda Tribe
IDENTIFIKASI INTERAKSI OBAT POTENSIAL PADA PASIEN STROKE RAWAT INAP DI RSUP PROF. DR. R. D. KANDOU MANADO
Authors: Solang Natasia G , Wiyono Weny , Mpila Deby Afriani 
Published: April 2021

ABSTRACTMost stroke patients receive polypharmacy, because most stroke patients have complications. Stroke therapy is important because if an interaction occurs, it can cause an increased risk of hospitalized patients and higher health care costs. This study is a descriptive study which aims to determine the prevalence of potential drug interactions that occur in inpatients of stroke hospitalization at Prof. Dr. R. D. Kandou Manado with retrospective data collection in October-December 2017. Samples were obtained as many as 40 patients. The results showed potential drug interactions in 20 patients (50%), with 57 potential interactions. Based on the mechanism, 30 events (52.63%) were pharmacokinetic, 15 events (26.31%) included in the pharmacokinetic and pharmacodynamic combination and 12 events (21.05%) were pharmacodynamic. The potential severity of the drug, at the moderate level was found to be 27 potential (47.36%), at the minor level 16 potential (28.07%) and at the major level with 14 potential (24.56%). Keywords: Drug Interaction, Stroke ABSTRAKKebanyakan pasien stroke menerima obat polifarmasi karena sebagian besar pasien stroke mengalami komplikasi. Terapi penyakit stroke sangat penting karena jika terjadi interaksi dapat menyebabkan peningkatan risiko pasien dirawat rawat inap dan biaya perawatan kesehatan akan lebih tinggi. Penelitian ini merupakan penelitian deskriptif yang bertujuan untuk mengetahui prevalensi interaksi obat potensial yang terjadi pada pasien stroke rawat inap di RSUP Prof. Dr. R. D. Kandou Manado dengan pengambilan data secara retrospektif pada bulan oktober-desember 2017. Sampel diperoleh sebanyak 40 pasien. Hasil penelitian menunjukan adanya interaksi obat potensial pada 20 pasien (50%), dengan jumlah potensial interaksi sebanyak 57 kejadian. Berdasarkan mekanismenya, 30 kejadian (52,63%) merupakan farmakokinetik, 15 kejadian (26,31%) termasuk dalam kombinasi farmakokinetik dan farmakodinamik dan 12 kejadian (21,05%) merupakan farmakodinamik. Tingkat keparahan potensial interaksi obat, pada tingkat moderate didapati 27 potensi (47,36%), pada tingkat minor 16 potensi (28,07%) dan pada tingkat major dengan 14 potensi (24,56%). Kata Kunci: Interaksi Obat, Stroke
UJI AKTIVITAS ANTIMIKROBA DARI JAMUR LAUT YANG BERASOSIASI DENGAN ALGA Halimeda opuntia
Authors: Djakatara Ridwan Sukardi , Wewengkang Defny S , Rotinsulu Henki 
Published: April 2021

ABSTRACT Algae is a place of life for various microorganisms symbiosis with it, one of which is fungi. Marine fungi are known to have an important contribution to the marine ecosystem. Many types of marine fungi that have been isolated and are known to produce a number of antimicrobial compounds were become a new choice in the world of health. This study aims to determine the antimicrobial activity of isolates fungi which associated with Halimeda opuntia algae collected from the Bay of Manado against Staphylococcus aureus, Escherichia coli, and Candida albicans. The results showed extracts of fungi that were associated with algae Halimeda opuntia did not possesed antimicrobial activity against S. aureus and E.coli and C. albicans. Keywords: Antimicrobials, marine fungi, Halimeda opuntia ABSTRAK Alga merupakan tempat hidup berbagai mikroorganisme yang bersimbiosis dengannya, salah satunya ialah jamur. Jamur laut diketahui memiliki kontribusi yang penting bagi ekosistem laut. Banyak jenis jamur laut yang telah diisolasi dan diketahui menghasilkan sejumlah senyawa antimikroba yang kini menjadi pilihan baru di dunia kesehatan. Penelitian ini bertujuan untuk mengetahui adanya aktivitas antimikroba dari isolat jamur yang berasosiasi dengan alga Halimeda opuntia yang diperoleh dari Teluk Manado terhadap bakteri Staphylococcus aureus, Escherichia coli, dan jamur Candida albicans. Hasil penelitian menunjukkan ekstrak dari jamur yang berasosiasi dengan alga Halimeda opuntia tidak memiliki aktivitas antimikroba terhadap bakteri S. aureus dan E. coli dan jamur C. albicans. Kata kunci : Antimikroba , jamur laut , Halimeda opuntia
EVALUASI PENYIMPANAN DAN PENDISTRIBUSIAN OBAT DI INSTALASI FARMASI RSUD NOONGAN, KABUPATEN MINAHASA PROVINSI SULAWESI UTARA
Authors: Monibala Tiarma , Citraningtyas Gayatri , Yamlean Paulina V. Y. 
Published: April 2021

ABSTRACTDrug management is one aspect of hospital management that is very important in providing overall health services because the inefficiency and ineffectiveness of drug management will have a negative impact on hospitals both medically, socially and economically. This study aims to evaluate the storage and distribution of drugs in accordance with the Regulation of the Minister of Health No. 72 of 2016 in Pharmacy Installation of Noongan District Hospital using a descriptive method with a retrospective and prospective approach. The results showed that the drug storage system in the Pharmacy Installation of Noongan General Hospital as a whole was not in accordance with the Regulation of the Minister of Health No. 72 of 2016 such as, warehouses that are not too large to store all drug supplies, the absence of regulators of humidity, the absence of pedestal boards and drugs placed directly on the floor, while the process of drug distribution is in accordance with Minister of Health Regulation No. 72 of 2016 using the Centralization and Individual methods for medicines and the Floor Stock method for Medical Materials. Keywords: Storage, Distribution, Medicine, Pharmacy Installlation Noongan District Hospital ABSTRAK Pengelolaan obat merupakan salah satu segi manajemen rumah sakit yang sangat penting dalam penyediaan pelayanan kesehatan secara keseluruhan karena ketidakefisienan dan ketidaklancaran pengelolaan obat akan memberi dampak negatif terhadap rumah sakit baik secara medik, sosial, maupun secara ekonomi. Penelitian ini bertujuan untuk mengevaluasi penyimpanan dan pendistribusian obat sesuai dengan Peraturan Menteri Kesehatan No. 72 Tahun 2016 di Instalasi Farmasi RSUD Noongan menggunakan metode deskriptif dengan pendekatan retrospektif dan prospektif. Hasil penelitian menunjukkan bahwa sistem penyimpanan obat di Instalasi Farmasi RSUD Noongan secara keseluruhan belum sesuai dengan Peraturan Menteri Kesehatan No. 72 Tahun 2016 seperti, gudang yang tidak terlalu luas untuk menyimpan semua persediaan obat, tidak adanya pengatur kelembaban, tidak adanya papan alas dan obat diletakkan langsung dilantai, sedangkan pada proses pendistribusian obat telah sesuai dengan Peraturan Menteri Kesehatan No. 72 Tahun 2016 dengan menggunakan metode Sentralisasi dan Perorangan untuk obat-obatan dan metode Floor Stock untuk Bahan Medis Habis Pakai. Kata Kunci : Penyimpanan, Pendistribusian, Obat, Instalasi Farmasi RSUD Noongan
UJI AKTIVITAS ANTIOKSIDAN DARI EKSTRAK ETANOL DAUN Mimosa pudica Linn. MENGGUNAKAN METODE DPPH
Authors: Wulan Wulan , Yudistira Adithya , Rotinsulu Henki 
Published: April 2021

ABSTRACT Antioxidant are compounds that can inhibit the oxidation rate of other molecules or neutralize free radicals. Putri Malu Leaf (Mimosa pudica Linn.) is not yet widely known as a medicinal plant. Through phytochemical screening, Mimosa pudica Linn. leaves known to have antioxidant compounds such as flavonoids, alkaloids, terpenoids, saponins and coumarin. This study aims to determine how much the antioxidant content in the extract of Mimosa pudica Linn. leaves using DPPH method with a concentration of 100 mg/L, 75 mg/L, 50 mg/L and 25 mg/L and Vitamin C as a positive control. Each sampel was made three repetitions of the test. The test uses a UV-Vis Spectrophotometer. The highest results were obtained from the concentration of 100 mg/L in the second repetition of 89.74%. The highest average percentage of yield obtained is at a concentration of 100 mg/L. Based on the result obtained from Mimosa pudica Linn. leaf extract seems like that the ethanol extract of Mimosa pudica Linn. leaves has high antioxidant activity. Keywords: Antioxidant, DPPH, Mimosa pudica Linn. ABSTRAK Antioksidan ialah senyawa yang mampu menghambat laju oksidasi molekul lain atau menetralisir radikal bebas. Daun Putri Malu (Mimosa pudica Linn.) belum dikenal luas sebagai tanaman obat.Melalui skrining fitokimia, daun Mimosa pudica Linn.diketahui memiliki senyawa antioksidan seperti flavonoid, alkaloid, terpenoid, saponin dan kumarin. Penelitian ini bertujuan untuk mengetahui seberapa besar kandungan antioksidan didalam ekstrak tanaman daun Mimosa pudica Linn.menggunakan metode DPPH dengan konsentrasi 100 mg/L, 75 mg/L, 50 mg/L dan 25 mg/L dan Vitamin C sebagai kontrol positif. Masing-masing sampel dibuat tiga kali pengulangan uji.Pengujian menggunakan alat Spektrofotometer UV-Vis. Terlihat hasil tertinggi diperoleh dari konsentrasi 100 mg/L pada pengulangan ke-II yaitu sebesar 89,74%. Rata-rata persentase hasil yang diperoleh tertinggi ialah pada konsentrasi 100 mg/L. Berdasarkan hasil yang diperoleh dari ekstrak daun Mimosa pudica Linn.terlihat bahwa ekstrak etanol daun Mimosa pudica Linn. memiliki aktivitas antioksidan yang tinggi. Kata Kunci : Antioksidan, DPPH,Mimosa pudica Linn.
IDENTIFIKASI TINGKAT KEPATUHAN PASIEN GERIATRI YANG MENDERITA HIPERTENSI DISERTAI PENYAKIT PENYERTA DI RSU PANCARAN KASIH MANADO PERIODE SEPTEMBER-OKTOBER 2018
Authors: Runtuwene Widia N , Wiyono Weny I , Yudistira Adithya 
Published: April 2021

ABSTRACTHypertension is one of chronic disease with commonly treatment for lifetime. The adherence of geriatric patients in following treatment very important that doesn’t happen can lead to death. This type of research is a descriptive study. The population of this study amounted to 465 patients. The number of samples taken was 40 patients. The sampling technique is consecutive sampling. The level of adherence was measured using the Modified MoriskyAdherence Scale-8 (MMAS-8)questionnaire. From the results of this study it can be concluded that geriatric patients who do treatment at the manado pancaran kasih hospital have a high level of adherence of 10%, have a moderate level of adherence of 40%, and have a low level of adherence of 50%. The results of this study found a problem related to the adherence of geriatric patients aged 60-69 years who took medication at the manado pancaran kasih hospital, namely because of forgetfulness and lack of information obtained from health workers regarding the patients condition and the importance of drugs to drink continue.Keywords : Hypertension, Geriatric, Adherence. ABSTRAKHipertensi merupakan salah satu penyakit kronis dengan pengobatan yang umumnya seumur hidup.Kepatuhan pasien geriatri dalam menjalani pengobatan sangat penting agar tidak terjadi komplikasi berbagai penyakit yang dapat berujung pada kematian. Jenis penelitian ini adalah penelitian deskriptif.Populasi dari penelitian ini berjumlah 465 pasien.Jumlah sampel yang di ambil sebanyak 40 pasien.Teknik pengambilan sampel secara consecutive sampling.Tingkat kepatuhan di ukur dengan menggunakan Kuesioner MMAS-8 (Modified MoriskyAdherence Scale). Hasil penelitian ini dapat disimpulkan pasien geriatri yang melakukan pengobatan di RSU Pancaran Kasih Manado memiliki tingkat kepatuhan tinggi sebanyak 10%, memiliki tingkat kepatuhan sedang sebanyak 40%, dan memiliki tingkat kepatuhan rendah sebanyak 50%. Hasil penelitian ini mendapatkan masalah terkait kepatuhan pasien geriatri yang berusia 60-69 yang melakukan pengobatan di RSU Pancaran Kasih Manado yaitu karena lupa dan kurangya informasi yang didapatkan pasien dari tenaga kesehatan terkait kondisi pasien dan pentingnya pengobatan secara kontinu.Kata Kunci : Hipertensi, Geriatri, Kepatuhan.
AKTIVITAS ANTIBAKTERI DAN ANALISIS KLT-BIOAUTOGRAFI DARI FRAKSI DAUN MANGGIS (Garcinia mangostana L.)
Authors: Paputungan Ayu Natasya , Lolo Widya Astuty , Jayanto Imam 
Published: April 2021

Mangosteen leaves have flavonoid compounds, tannins, and saponins that can be efficacious as antibacterial. The aim of this study was to determine the fraction of mangosteen leaves having an antibacterial effect and knowing the class of compounds identified as having antibacterial activity after TLC- Bioautography testing was carried out. The samples were extracted using 96% maceratarion method and fractioned using liquid-liquid fractionation method with methanol, n-hexane and ethyl acetate solvents, antibacterial activity using agar diffusion method (Kirby and Bauer) with 3 concetrations namely 10%, 20% and 30%. Thin Layer Chromatography (TLC) uses n-hexane and chloroform solvens. TLC-Bioautography uses contact bioautography methods. The resultd showed that mangosteen leaves in methanol fraction with a concentration of 30% had a very large inhibitory activity again Staphylococcus aureus and ethyl acetate fraction with a concentration of 30% had the gratest antibacterial activity against Escherichia coli. The results of the TLC- Bioautography study showed that the flavonoids compounds after spraying with AlCl3 and the mangosteen leaf Biosutography test had inhibitory zone activity against the bacteria Staphylococcus aureus dan Escherichia coli. Keywords: Mangosteen Leaves. Antibacterial, TLC Bioautography. ABSTRAK Daun manggis mempunyai senyawa flavonoid, tanin, dan saponin yang dapat berkhasiat sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui fraksi daun manggis memiliki efek antibakteri dan mengetahui golongan senyawa yang teridentifikasi memiliki aktivitas antibakteri setelah dilakukan pengujian KLT Bioautografi. Sampel diektrak dengan metode maserasi dengan pelarut 96% dan difraksinasi dengan metode fraksinasi cair-cair dengan pelarut metanol, n-heksan dan etil asetat, aktivitas antibakteri menggunakan metode difusi agar (Kirby and Bauer) dengan 3 kosentrasi yaitu 10%, 20% dan 30%. Kromatografi Lapis Tipis (KLT) menggunakan pelarut n-heksan dan klorofom. KLT-Bioautografi menggunakan metode bioautografi kontak. Hasil penelitian menunjukan daun manggis pada fraksi metanol dengan kosentrasi 30% memiliki aktivitas zona hambat ppaling besar terhadapat bakteri Staphylococcus aureus dan fraksi etil asetat dengan kosentrasi 30% memiliki aktivitas antibakteri paling besar terhadap Escherichia coli. Hasil penelitian KLT-Bioautografi menunjukan golongan senyawa flavonoid setelah disemprotkan dengan AlCl3 dan uji Bioautografi daun manggis memiliki aktivitas zona hambat terhadap bakteri Staphylococcus aureus dan Escherichia coli. Kata kunci : Daun Manggis, Antibakteri, KLT- Bioautografi.
UJI DAYA HAMBAT ORGANISME LAUT SPONS Amphimedon sp., TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus, Escherichia coli, DAN Jamur Candida albicans
Authors: Latif Rizky Akbar , Wewengkang Defny S. , Rotinsulu Henki 
Published: April 2021

Sponges are marine animals that can produce bioactives that are useful as anti-virus, anti-fungal, antibiotic, anti-cancer, anti-inflammatory, and antioxidants. Amphimedon sp., sponge itself is found in the waters of Lembeh islands, the City of Bitung. This study was to determine the inhibitory activity against the microorganisms growth of Amphimedon sp., sponge, against microbes of Staphylococcus aureus, Escherichia coli, and Candida albicans. Based on the results of the study, the extracts and fractions of Amphimedon sp., sponge samples did not have microbial inhibitory activity against the test microbes of Staphylococcus aureus, Escherichia coli, and Candida albicans Keywords : Amphimedon sp., Antimicrobial, Staphylococcus aureus, Escherichia coli, Candida albicans ABSTRAK Spons merupakan hewan laut yang dapat menghasilkan bioaktif yang bermanfaat sebagai anti virus, anti jamur, antibiotik, anti kanker, anti inflamasi, dan antioksidan. Spons Amphimedon sp sendiri ditemukan didaerah perairan pulau Lembeh kota bitung. Penelitian ini yaitu untuk mengetahui aktivitas daya hambat pertumbuhan mikroorganisme dari spons Amphimedon sp., terhadap mikroba Staphylococcus aureus, Escherichia coli, dan Candida albicans. Berdasarkan hasil penelitian menunjukkan ekstrak dan fraksi sampel spons Amphimedon sp., tidak memiliki aktivitas daya hambat terhadap mikroba uji Staphylococcus aureus, Escherichia coli, dan Candida albicans Kata kunci : Amphimedon sp., Antimikroba, Staphylococcus aureus, Escherichia coli, Candida albicans