bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Class II functional treatment on facial attractiveness, as perceived by professionals and laypeople
Authors: Santori Federica , Masedu Francesco , Ciavarella Domenico , Staderini Edoardo , Chimenti Claudio , Tepedino Michele 
Published: July 2021

AbstractThe literature offers different perspectives for and against two-phase treatment of skeletal Class II malocclusion. Facial attractiveness is an important aspect to take into account, given that children with skeletal Class II are often bullied by their peers and have low self-esteem and a lower social perception. The aim of the present study was to evaluate the aesthetic perception of facial profiles by a large number of observers, before and after treatment with a functional appliance, compared to untreated controls. The pre- and post-treatment cephalograms of 20 Class II subjects treated with Sander’s bite-jumping appliance and 20 untreated historical controls were collected and transformed into black and white silhouettes depicting only the lower third of the face. An online questionnaire comprising the silhouettes of the two groups, three “calibration” profiles and an “ideal” profile was submitted to dentists, orthodontists, undergraduates and laypeople, asking them to rate the profile’s attractiveness using a Visual Analogue Scale (VAS). The effect of treatment, and observers’ age, expertise and gender were analysed. The calibration images and the ideal profiles were used to evaluate the coherence of each observer’s judgement. The protocol was approved by the local Ethics Committee. Nine-hundred and ten questionnaires were collected. Treated subjects showed a larger improvement of facial attractiveness compared to controls. A significant effect of gender on the observer’s ratings was observed. Some observers showed incoherent judgement, which had a significant effect on the regression model. In conclusion, early treatment with functional appliances seems to improve patients’ facial aesthetics. This improvement is perceived equally by dental professionals and laypeople.
BeEAM conditioning regimen is a safe, efficacious and economical alternative to BEAM chemotherapy
Authors: Hahn Logan , Lim Hyun , Dusyk Tanner , Sabry Waleed , Elemary Mohamed , Stakiw Julie , Danyluk Pat , Bosch Mark 
Published: July 2021

AbstractIn many stem cell transplant centres, BCNU, etoposide, cytarabine and melphalan (BEAM) high-dose chemotherapy (HDCT) has been replaced by the more economic and available bendamustine, etoposide, cytarabine, melphalan (BeEAM) regimen. However, there is a paucity of information on the efficacy and safety of BeEAM HDCT. We describe our experience with BeEAM HDCT in terms of safety, efficacy and cost-savings. We compare overall and progression-free survival to a cohort of patients previously transplanted at our institution with the older BEAM regimen. We performed a retrospective chart review of 41 lymphoma patients undergoing BeEAM HDCT at the Royal University Hospital in Saskatoon, Saskatchewan between 2015 and 2019 to elicit regimen safety in the first 100 days post-transplant. Furthermore, we calculated overall and progression-free survival and constructed corresponding Kaplan–Meier curves, comparing the results to a historical cohort of BEAM patients (n = 86). Finally, we conducted an economic analysis using the financials available at our centre’s pharmacy. With regards to BeEAM HDCT, we report a 100-day transplant-related mortality of 2.4%. Additionally, we report acceptable rates of typhlitis (27%), grade III–IV mucositis (4.9%) and grade III–IV nephrotoxicity (2.4%). In terms of overall and progression-free survival, we found no statistical difference between BeEAM and BEAM (p = 0.296; 0.762, respectively). Finally, our economic analysis revealed a net savings of $21,200 CAD per transplant when BeEAM is used in replacement of BEAM. The acceptable safety profile of BeEAM and its comparable efficacy to BEAM are encouraging for the perseverance of this cost-effective HDCT regimen.
Reversal of senescence-associated beta-galactosidase expression during in vitro three-dimensional tissue-engineering of human chondrocytes in a polymer scaffold
Authors: Katoh Shojiro , Fujimaru Atsuki , Iwasaki Masaru , Yoshioka Hiroshi , Senthilkumar Rajappa , Preethy Senthilkumar , Abraham Samuel J. K. 
Published: July 2021

AbstractRegenerative medicine applications require cells that are not inflicted with senescence after in vitro culture for an optimal in vivo outcome. Methods to overcome replicative senescence include genomic modifications which have their own disadvantages. We have evaluated a three-dimensional (3D) thermo-reversible gelation polymer (TGP) matrix environment for its capabilities to reverse cellular senescence. The expression of senescence-associated beta-galactosidase (SA-βgal) by human chondrocytes from osteoarthritis-affected cartilage tissue, grown in a conventional two-dimensional (2D) monolayer culture versus in 3D-TGP were compared. In 2D, the cells de-differentiated into fibroblasts, expressed higher SA-βgal and started degenerating at 25 days. SA-βgal levels decreased when the chondrocytes were transferred from the 2D to the 3D-TGP culture, with cells exhibiting a tissue-like growth until 42–45 days. Other senescence associated markers such as p16INK4a and p21 were also expressed only in 2D cultured cells but not in 3D-TGP tissue engineered cartilage. This is a first-of-its-kind report of a chemically synthesized and reproducible in vitro environment yielding an advantageous reversal of aging of human chondrocytes without any genomic modifications. The method is worth consideration as an optimal method for growing cells for regenerative medicine applications.
Adverse perinatal outcomes and its associated factors among adult and advanced maternal age pregnancy in Northwest Ethiopia
Authors: Getaneh Temesgen , Asres Azezu , Hiyaru Toyiba , Lake Selamawit 
Published: July 2021

AbstractEven though reduction of neonatal mortality is needed to achieve Sustainable Development Goals 2030, advanced maternal age is still an independent and a substantial risk factor for different adverse perinatal outcomes, in turn causes neonatal morbidity and mortality. In Ethiopia, research has validated that advanced maternal age is a significant factor in adverse perinatal outcomes, but researches which addressed or estimated its adverse perinatal outcomes are limited, reported inconsistent result and specifically no study was done in the study area. Therefore, this study was aimed to compare adverse perinatal outcomes and its associated factors among women with adult and advanced maternal age pregnancy in Northwest Ethiopia. Comparative cross-sectional study was conducted in Awi Zone, public hospitals, Northwest Ethiopia. Systematic random sampling was employed to select 348 adult and 176 advanced aged pregnant women. Structured questionnaire were used to collect the data. The collected data were analyzed using Statistical Package for the Social Sciences version 25. Binary and multivariate logistic regressions were fitted to assess the association between adverse perinatal outcomes and explanatory variables. P-value less than 0.05 was used to declare statistical significance. Significant percentage of advanced aged women (29.1%) had adverse perinatal outcomes compared to (14.5%) adult aged women. Similarly, proportion low birth weight, preterm birth and low Apgar score were significantly higher among advanced maternal age. The odds of composite adverse perinatal outcomes were higher among advanced maternal age women when compared to adult aged women (AOR 2.01, 95% CI 1.06, 3.79). No formal education (AOR 2.75, 95% CI 1.27, 5.95), short birth interval (AOR 2.25, 95% CI 1.07, 4.73) and complications during pregnancy (AOR 2.12, 95% CI 1.10, 4.10) were also factors significantly associated with adverse perinatal outcomes. Being advanced maternal age is at higher risk for adverse perinatal outcomes compared to adult aged women. Maternal illiteracy, short birth interval and complications during pregnancy were also significantly associated with adverse perinatal outcomes. Access of equal education, provision of family planning and perinatal care (including early detection and management of complication) is recommended.
2D-MoS2 goes 3D: transferring optoelectronic properties of 2D MoS2 to a large-area thin film
Authors: Timpel Melanie , Ligorio Giovanni , Ghiami Amir , Gavioli Luca , Cavaliere Emanuele , Chiappini Andrea , Rossi Francesca , Pasquali Luca , Gärisch Fabian , List-Kratochvil Emil J. W. , Nozar Petr , Quaranta Alberto , Verucchi Roberto , Nardi Marco V. 
Published: July 2021

AbstractThe ongoing miniaturization of electronic devices has boosted the development of new post-silicon two-dimensional (2D) semiconductors, such as transition metal dichalcogenides, one of the most prominent materials being molybdenum disulfide (MoS2). A major obstacle for the industrial production of MoS2-based devices lies in the growth techniques. These must ensure the reliable fabrication of MoS2 with tailored 2D properties to allow for the typical direct bandgap of 1.9 eV, while maintaining large-area growth and device compatibility. In this work, we used a versatile and industrially scalable MoS2 growth method based on ionized jet deposition and annealing at 250 °C, through which a 3D stable and scalable material exhibiting excellent electronic and optical properties of 2D MoS2 is synthesized. The thickness-related limit, i.e., the desired optical and electronic properties being limited to 2D single/few-layered MoS2, was overcome in the thin film through the formation of encapsulated highly crystalline 2D MoS2 nanosheets exhibiting a bandgap of 1.9 eV and sharp optical emission. The newly synthesized 2D-in-3D MoS2 structure will facilitate device compatibility of 2D materials and confer superior optoelectronic device function.
Multi-scale modeling of intensive macroalgae cultivation and marine nitrogen sequestration
Authors: Zollmann Meiron , Rubinsky Boris , Liberzon Alexander , Golberg Alexander 
Published: July 2021

AbstractMulti-scale macroalgae growth models are required for the efficient design of sustainable, economically viable, and environmentally safe farms. Here, we develop a multi-scale model for Ulva sp. macroalgae growth and nitrogen sequestration in an intensive cultivation farm, regulated by temperature, light, and nutrients. The model incorporates a range of scales by incorporating spatial effects in two steps: light extinction at the reactor scale (1 m) and nutrient absorption at the farm scale (1 km). The model was validated on real data from an experimental reactor installed in the sea. Biomass production rates, chemical compositions, and nitrogen removal were simulated under different seasons, levels of dilution in the environment and water-exchange rate in the reactor. This multi-scale model provides an important tool for environmental authorities and seaweed farmers who desire to upscale to large bioremediation and/or macroalgae biomass production farms, thus promoting the marine sustainable development and the macroalgae-based bioeconomy.
Mechanism of BIP-4 mediated inhibition of InsP3Kinase-A
Authors: Paraschiakos Themistoklis , Flat Wilhelm , Chen Ya , Kirchmair Johannes , Windhorst Sabine 
Published: July 2021

Abstract
Overexpression of the neuronal InsP3kinase-A increases malignancy of different tumor types. Since InsP3kinase-A highly selectively binds Ins(1,4,5)P3, small molecules competing with Ins(1,4,5)P3 provide a promising approach for the therapeutic targeting of InsP3kinase-A. Based on this consideration, we analyzed the binding mechanism of BIP-4 (2-[3,5-dimethyl-1-(4-nitrophenyl)-1H-pyrazol-4-yl]-5, 8-dinitro-1H-benzo[de]isoquinoline-1,3(2H)-dione), a known competitive small-molecule inhibitor of Ins(1,4,5)P3. We tested a total of 80 BIP-4 related compounds in biochemical assays. The results of these experiments revealed that neither the nitrophenyl nor the benzisochinoline group inhibited InsP3kinase-A activity. Moreover, none of the BIP-4 related compounds competed for Ins(1,4,5)P3, demonstrating the high selectivity of BIP-4. To analyze the inhibition mechanism of BIP-4, mutagenesis experiments were performed. The results of these experiments suggest that the nitro groups attached to the benzisochinoline ring compete for binding of Ins(1,4,5)P3 while the nitrophenyl group is associated with amino acids of the ATP-binding pocket. Our results now offer the possibility to optimize BIP-4 to design specific InsP3Kinase-A inhibitors suitable for therapeutic targeting of the enzyme.
Intelligibility, Articulation Rate, Fluency, and Communicative Efficiency in Typically Developing Children
Authors: Schölderle Theresa , Haas Elisabet , Baumeister Stefanie , Ziegler Wolfram 
Published: July 2021

Purpose
This article describes the developmental trajectories of four communication-related parameters (i.e., intelligibility, articulation rate, fluency, and communicative efficiency) in a cross-sectional study of typically developing children between 3 and 9 years. The four target parameters were related to auditory-perceptual parameters of speech function.

Method
One hundred forty-four typically developing children (ages 3;0–9;11 [years;months]; 72 girls and 72 boys) participated. Speech samples were collected using the materials of the Bogenhausen Dysarthria Scales for Childhood Dysarthria, a German assessment tool for childhood dysarthria, and analyzed following established auditory-perceptual criteria on relevant speech functions. To assess intelligibility, naïve listeners transcribed sentences repeated by the children. Articulation rate and fluency were measured by acoustic analyses; communicative efficiency was determined by multiplying the proportion of correctly transcribed syllables by speech rate.

Results
Intelligibility showed a steep developmental trajectory, with the majority of children obtaining a proportion of intelligible syllables close to 1.0 at the age of 5 years. Articulation rate demonstrated a flatter trajectory, with high variability still within the older children. Disfluencies, on the contrary, occurred only in the youngest children. By definition, communicative efficiency shared the characteristics of intelligibility and rate curves. A principal component analysis revealed, among other findings, strong connections between intelligibility and articulation, as well as between communicative efficiency, articulation, and rate measures.

Conclusions
While children speak intelligibly, in terms of the applied assessment, at a comparably young age, other communication-relevant parameters show a slower developmental progress. Knowledge on the typical development of communication-related parameters and on their complex relationships with functional speech variables is crucial for the clinical assessment of childhood dysarthria.

Supplemental Material

https://doi.org/10.23641/asha.14880285
One-dimensional prominence threads
Authors: Terradas J. , Luna M. , Soler R. , Oliver R. , Carbonell M. , Ballester J. L. 
Published: July 2021

Context. Threads are the building blocks of solar prominences and very often show longitudinal oscillatory motions that are strongly attenuated with time. The damping mechanism responsible for the reported oscillations is not fully understood yet.
Aims. To understand the oscillations and damping of prominence threads we must first investigate the nature of the equilibrium solutions that arise under static conditions and under the presence of radiative losses, thermal conduction, and background heating. This provides the basis to calculate the eigenmodes of the thread models.
Methods. The non-linear ordinary differential equations for hydrostatic and thermal equilibrium under the presence of gravity are solved using standard numerical techniques and simple analytical expressions are derived under certain approximations. The solutions to the equations represent a prominence thread, a dense and cold plasma region of a certain length that connects with the corona through a prominence corona transition region (PCTR). The solutions can also match with a chromospheric-like layer if a spatially dependent heating function localised around the footpoints is considered.
Results. We have obtained static solutions representing prominence threads and have investigated in detail the dependence of these solutions on the different parameters of the model. Among other results, we show that multiple condensations along a magnetic field line are possible, and that the effect of partial ionisation in the model can significantly modify the thermal balance in the thread, and therefore their length. This last parameter is also shown to be comparable to that reported in the observations when the radiative losses are reduced for typical thread temperatures.
The ALPINE-ALMA [CII] survey
Authors: Pozzi F. , Calura F. , Fudamoto Y. , Dessauges-Zavadsky M. , Gruppioni C. , Talia M. , Zamorani G. , Bethermin M. , Cimatti A. , Enia A. , Khusanova Y. , Decarli R. , Le Fèvre O. , Capak P. , Cassata P. , Faisst A. L. , Yan L. , Schaerer D. , Silverman J. , Bardelli S. , Boquien M. , Enia A. , Narayanan D. , Ginolfi M. , Hathi N. P. , Jones G. C. , Koekemoer A. M. , Lemaux B. C. , Loiacono F. , Maiolino R. , Riechers D. A. , Rodighiero G. , Romano M. , Vallini L. , Vergani D. , Zucca E. 
Published: July 2021

Aims. The dust content of normal galaxies and the dust mass density (DMD) at high-z (z > 4) are unconstrained given the source confusion and the sensitivity limitations of previous observations. The ALMA Large Program to INvestigate [CII] at Early times (ALPINE), which targeted 118 ultra-violet (UV)-selected star-forming galaxies at 4.4 < z < 5.9, provides a new opportunity to tackle this issue for the first time with a statistically robust dataset.
Methods. We exploited the rest-frame far-infrared (FIR) fluxes of 23 galaxies individually detected in their continuum emission, as well as stacked continuum images, to measure the dust content of the 118 UV-selected ALPINE galaxies. We focused on the dust scaling relations and, by comparison with predictions from chemical evolution models, we probed the evolutionary stage of UV-selected galaxies at high-z. By using the observed correlation between the UV luminosity and the dust mass, we estimated the DMD of UV-selected galaxies at z ∼ 5, weighting the galaxies by means of the UV luminosity function. The derived DMD is compared with the value we estimated from ten ALPINE galaxies blindly detected in the FIR continuum, at the redshift of the ALPINE targets.
Results. Our ALMA survey allows the exploration for the first time of the dust content in normal star-forming galaxies at z > 4 in a statistically robust sample of sources. The comparison of the observed dust scaling relations with chemical evolution models suggests that ALPINE galaxies are not likely progenitors of disc galaxies, but of intermediate- and low-mass proto-spheroids, resulting in present-day bulges of spiral or elliptical galaxies. Interestingly, this conclusion is in line with the independent morphological analysis that shows that the majority (∼70%) of the dust-continuum detected galaxies have a disturbed morphology. The DMD obtained at z ∼ 5 from UV-selected sources is ∼30% of the value obtained from blind FIR-selected sources, showing that the UV selection misses the most dust-rich, UV-obscured galaxies.
[C II] 158 μm line emission from Orion A I. A template for extragalactic studies?
Authors: Pabst C. H. M. , Hacar A. , Goicoechea J. R. , Teyssier D. , Berné O. , Wolfire M. G. , Higgins R. D. , Chambers E. T. , Kabanovic S. , Güsten R. , Stutzki J. , Kramer C. , Tielens A. G. G. M. 
Published: July 2021

Context. The [C II] 158 μm fine-structure line is one of the dominant coolants of the neutral interstellar medium. It is hence one of the brightest far-infrared (FIR) emission lines and can be observed not only in star-forming regions throughout the Galaxy, but also in the diffuse interstellar medium and in distant galaxies. [C II] line emission has been suggested to be a powerful tracer of star formation.
Aims. We aim to understand the origin of [C II] emission and its relation to other tracers of interstellar gas and dust. This includes a study of the heating efficiency of interstellar gas as traced by the [C II] line to test models of gas heating.
Methods. We made use of a one-square-degree map of velocity-resolved [C II] line emission toward the Orion Nebula complex, including M 43 and NGC 1977. We employed Herschel FIR photometric images to determine dust properties. Moreover, we compared with Hα emission from the ionized gas, Spitzer mid-infrared photometry to trace hot dust and large polycyclic aromatic hydrocarbons (PAHs), and velocity-resolved IRAM 30m CO(2–1) observations of the molecular gas.
Results. The [C II] intensity is tightly correlated with PAH emission in the IRAC 8 μm band and FIR emission from warm dust. However, the [C II] intensity depends less than linearly on the 8 μm and FIR intensity, while 8 μm and FIR intensities are approximately linearly correlated. The correlation between [C II] and CO(2–1) does not show a clear trend and is affected by the detailed geometry of the region. We find particularly low [C II]-over-FIR intensity ratios toward large columns of (warm and cold) dust, which suggest the interpretation of the “[C II] deficit” in terms of a “FIR excess”.
Conclusions. In terms of the [C II] deficit, we find clear evidence in our data for the importance of [O I] 63 μm emission in the photodissociation regions (PDRs) associated with the Huygens region. A smaller contribution is made by a decreased heating efficiency in regions of high UV irradiation. FIR emission from deeply embedded protostars leads to palpably deficient [C II]/FIR intensity ratios. The [C II] directly associated with the M 42, M 43, and NGC 1977 regions underestimates the star formation rate derived from extragalactic scaling relations. We ascribe this to the importance of [C II] emission from low surface brightness PDR surfaces of molecular clouds which are not included in our survey. Future studies of more active regions of massive star formation will be instrumental in validating the general applicability of these conclusions.
CIRP Secretion during Cardiopulmonary Bypass Is Associated with Increased Risk of Postoperative Acute Kidney Injury
Authors: Liu Wenyan , Yan Yang , Han Dan , Li Yongxin , Wang Qian , Li Jing , Liu Fengfeng , Zheng Xinglong 
Published: July 2021

Abstract
Background Systemic inflammation contributes to cardiac surgery–associated acute kidney injury (AKI). Cardiomyocytes and other organs experience hypothermia and hypoxia during cardiopulmonary bypass (CPB), which induces the secretion of cold-inducible RNA-binding protein (CIRP). Extracellular CIRP may induce a proinflammatory response.
Materials and Methods The serum CIRP levels in 76 patients before and after cardiac surgery were determined to analyze the correlation between CIRP levels and CPB time. The risk factors for AKI after cardiac surgery and the in-hospital outcomes were also analyzed.
Results The difference in the levels of CIRP (ΔCIRP) after and before surgery in patients who experienced cardioplegic arrest (CA) was 26-fold higher than those who did not, and 2.7-fold of those who experienced CPB without CA. The ΔCIRP levels were positively correlated with CPB time (r = 0.574, p < 0.001) and cross-clamp time (r = 0.54, p < 0.001). Multivariable analysis indicated that ΔCIRP (odds ratio: 1.003; 95% confidence interval: 1.000–1.006; p = 0.027) was an independent risk factor for postoperative AKI. Patients who underwent aortic dissection surgery had higher levels of CIRP and higher incidence of AKI than other patients. The incidence of AKI and duration of mechanical ventilation in patients whose serum CIRP levels more than 405 pg/mL were significantly higher than those less than 405 pg/mL (65.8 vs. 42.1%, p = 0.038; 23.1 ± 18.2 vs. 13.8 ± 9.2 hours, p = 0.007).
Conclusion A large amount of CIRP was released during cardiac surgery. The secreted CIRP was associated with the increased risk of AKI after cardiac surgery.