bluuebunny/crossref_metadata_2025_split huggingface dataset:
“I Don’t Identify with It”: A Qualitative Analysis of People’s Experiences of Living with Complex Regional Pain Syndrome
Authors: Antunovich Dana , Tuck Natalie , Reynolds Lisa M , Bean Debbie 
Published: March 2021

Abstract

Objective
Complex regional pain syndrome (CRPS) is a painful limb condition known to cause significant disability and distress. However, little previous research has explored CRPS from a patient perspective. The present qualitative study aimed to describe the experiences of people living with CRPS.

Subjects
Forty-eight people with CRPS participated in this research.

Methods
Participants completed a face-to-face or telephone interview about their perceptions and experiences of CRPS and completed three drawings to illustrate their experiences. Data were analyzed through reflexive thematic analysis, and images in drawings were grouped and coded by theme.

Results
Three overarching themes encapsulated the data, including that 1) people experience CRPS as a source of severe symptoms and emotional difficulties, 2) CRPS undermines personal and social identity, and 3) this results in psychological responses that protect against the emotional and social impact of severe symptoms. Psychological responses include: a) searching for an explanation, b) “nothing is my fault,” emphasizing a lack of personal responsibility and personal control, and c) detaching the limb from the self.

Conclusions
CRPS is experienced as highly threatening to physical ability, psychological state, and identity. In response to these threats, people may develop their own explanations for CRPS and may mentally detach themselves from responsibility, control, and the painful limb itself. Future research could explore the impact of these factors on psychological well-being and CRPS symptoms and outcomes.
Evaluation of nutritional strategies to slow growth rate then induce compensatory growth in 90-kg finishing pigs
Authors: Rao Zhong-Xing , Tokach Mike D , Woodworth Jason C , DeRouchey Joel M , Goodband Robert D , Gebhardt Jordan T 
Published: March 2021

Abstract
Two 44-d experiments were conducted to evaluate nutritional strategies with different concentrations of dietary lysine (and other amino acids) on growth rate and subsequent compensatory gain of 90-kg finishing pigs. Three diets were formulated to contain 0.70 (control), 0.50% and 0.18% standardized ileal digestible (SID) Lys. In Exp. 1, 356 pigs (Line 241 × 600, DNA; initially 89.0 ± 1.10 kg) were used with four treatments. From d 0 to 28, pigs received either the control or the 0.50%-Lys diet. On d 28, pigs either remained on these diets or were switched the 0.18%-Lys diet until d 44. There were 18 pens per treatment from d 0 to 28 and 9 pens per treatment from d 28 to 44. From d 0 to 28, pigs fed the 0.50%-Lys diet had decreased (P &lt; 0.001) ADG and G:F compared to those fed the control diet. From d 28 to 44, pigs switched to the 0.18%-Lys diet had decreased (P &lt; 0.05) ADG and G:F compared to pigs that remained on the control or 0.50%-Lys diets. From d 0 to 44, pigs fed 0.50%-Lys diet for 44-d had decreased (P &lt; 0.05) ADG, G:F, and percentage carcass lean compared to pigs fed the control diet. Pigs fed the 0.50%-Lys diet then the 0.18%-Lys diet had decreased (P &lt; 0.05) ADG and G:F compared to other treatments. Pigs fed the 0.50%-Lys diet for 44-d and pigs fed the control diet then 0.18%-Lys diet had decreased (P &lt; 0.05) ADG, G:F, and percentage carcass lean compared to control pigs. In Exp. 2, 346 pigs (Line 241 × 600, DNA; initially 88.6 ± 1.05 kg) were used to evaluate compensatory growth after varying durations of dietary lysine restriction. A total of four treatments were used including pigs fed the control diet for 44-d or fed the 0.18%-Lys diet for 14, 21, or 28-d and then fed the control diet until the conclusion of the experiment on d 44. There were nine pens per treatment. On average, pigs fed the 0.18%-Lys diet grew 49% slower than the control. Compared to the control, ADG of pigs previously fed the 0.18%-Lys diet increased (P &lt; 0.05) 28% during the first week after switching to the control diet and 12% for the rest of the trial. Despite this improvement, overall ADG, G;F, final BW, and percentage carcass lean decreased (linear, P &lt; 0.05) as the duration of Lys restriction increased. In summary, feeding Lys-restricted diets reduced the ADG and G:F of finishing pigs. Compensatory growth can be induced in Lys-restricted finishing pigs, but the duration of restriction and recovery influences the magnitude of compensatory growth.
Incidental 18F-Florapronol Uptake in Meningioma
Authors: Lee Inki , Kong Joon Seog , Youn Sang Min , Lim Ilhan , Ha Jeong Ho 
Published: March 2021

Abstract
A 76-year-old woman underwent 18F-florapronol (18F-FC119S, an amyloid β imaging PET agent) PET, owing to cognitive impairment. 18F-florapronol PET images revealed an incidental 18F-florapronol uptake in the right frontal lobe. A well-enhancing extra-axial mass in the right frontal lobe was observed on MRI scans, suggesting a meningioma. After excision of the tumor, the biopsy results confirmed it as a meningothelial meningioma.
Quality of Life and Satisfaction in Transgender Men After Phalloplasty in a Retrospective Study
Authors: Papadopulos Nikolaos A. , Ehrenberger Benjamin , Zavlin Dmitry , Lellé Jean-Daniel , Henrich Gerhard , Kovacs Laszlo , Herschbach Peter , Machens Hans-Günther , Schaff Jürgen 
Published: March 2021

Background
Partly as a result of the increasing attention directed toward transgender individuals and despite much research work on the topic of quality of life (QOL) of transgender, there is still a lack of studies using standardized questionnaires in their evaluation.

Aims
We designed a survey to evaluate the influence of surgery after phalloplasty (osteofasciocutaneous fibula free flap or osteofasciocutaneous radial free forearm flap) on QOL, emotional stability, self-esteem, and psyche of postoperated transgender men.

Methods
The present study included 32 transgender men who had undergone gender-affirming surgery (GAS) exclusively in our department between 2000 and 2012. Apart from our self-developed, indication-specific questionnaire with questions on socioeconomic and demographic data as well as postoperative satisfaction, the testing instrument included 4 frequently used, standardized testing instruments, which we compared with normative data. These included (a) a self-assessment test Fragebogen zur Lebenszufriedenheit with questions on QOL consisting of 3 modules (general satisfaction, satisfaction with health, and satisfaction with body image/outer appearance), (b) the Freiburg Personality Inventory, (c) the Rosenberg Self-Esteem Questionnaire, and (d) the Patient Health Questionnaire 4.

Findings
Our self-developed, indication-specific questionnaire showed that 88% of our patients were very satisfied with the aesthetic result, 75% have had sex after surgery, and 72% were very satisfied with sexual function after GAS. Eighty-one percent had a strong improvement of QOL, and 91% would undergo the same treatment again. Eighty-four percent would recommend GAS to others. All patients lived as men fulltime.

Discussion
Our study reveals that GAS plays an important part in the interdisciplinary treatment of transgender individuals as it improves the QOL in transgender men in most aspects of everyday life and has a positive influence on the patients' psyche and self-esteem in a retrospective study.
Effects of open innovation breadth on industrial innovation input–output relationships
Authors: Frank Alejandro Germán , Benitez Guilherme Brittes , Ferreira Lima Mateus , Bernardi João Augusto Bonzanini 
Published: March 2021

PurposeOpen innovation breadth (OIB) considers the diversity of external collaboration partners for innovation. The authors investigate the moderating effect of OIB on the relationship between industrial innovation activities (innovation inputs) and industrial innovation results (innovation outputs).Design/methodology/approachThis study is based on secondary data from the Brazilian innovation survey, representing more than 30,000 innovative companies across 55 industrial sectors.FindingsThis study’s results show that OIB has different moderating effects regarding the several innovation input–output relationships. While OIB benefits some relationships, others are hampered by the diversity of collaboration partners.Originality/valueFew studies have addressed OIB at the macro level. Using the perspective of transaction cost economics (TCE), the authors discuss the contributions and limitations of OIB at the industry level.
Contribution of PCA/K-means methods to the mixed assessment of patient safety culture
Authors: Fourar Youcef Oussama , Djebabra Mebarek , Benhassine Wissal , Boubaker Leila 
Published: March 2021

PurposeThe assessment of patient safety culture (PSC) is a major priority for healthcare providers. It is often realized using quantitative approaches (questionnaires) separately from qualitative ones (patient safety culture maturity model (PSCMM)). These approaches suffer from certain major limits. Therefore, the aim of the present study is to overcome these limits and to propose a novel approach to PSC assessment.Design/methodology/approachThe proposed approach consists of evaluating PSC in a set of healthcare establishments (HEs) using the HSOPSC questionnaire. After that, principal component analysis (PCA) and K-means algorithm were applied on PSC dimensional scores in order to aggregate them into macro dimensions. The latter were used to overcome the limits of PSC dimensional assessment and to propose a quantitative PSCMM.FindingsPSC dimensions are grouped into three macro dimensions. Their capitalization permits their association with safety actors related to PSC promotion. Consequently, a quantitative PSC maturity matrix was proposed. Problematic PSC dimensions for the studied HEs are “Non-punitive response to error”, “Staffing”, “Communication openness”. Their PSC maturity level was found underdeveloped due to a managerial style that favors a “blame culture”.Originality/valueA combined quali-quantitative assessment framework for PSC was proposed in the present study as recommended by a number of researchers but, to the best of our knowledge, few or no studies were devoted to it. The results can be projected for improvement and accreditation purposes, where different PSC stakeholders can be implicated as suggested by international standards.
Challenges of being a digitally savvy principal
Authors: Richardson Jayson W. , Watts Jeremy Lucian Daniel , Sterrett William L. 
Published: March 2021

PurposeThe purpose of this study was to better understand the challenges faced by leaders who have demonstrated excellence in integrating technology into teaching and learning in P-12 schools in the United States.Design/methodology/approachThis case study of technology savvy P-12 school principals provides insights into how building leaders overcome digital technology innovation challenges. In the summer of 2017, the authors interviewed 12 of the 18 recipients of the NASSP Digital Principal Award. These principals serve as examples of how to lead schools in the digital age.FindingsUsing Bolman and Deal's (2013) conceptual framework, the authors analyzed the data around the four frames (i.e., political, structural, human resources, and symbolic) to understand the challenges of being a digital principal. Bolman and Deal posited leaders who function predominantly in a single frame may miss essential organizational change elements.Research limitations/implicationsThe authors recognize several limitations in this study. First, the nominating process for the NASSP Digital Principals award involves an application process. Thus, while these principals were recognized for meeting these criteria, it is possible that these awardees were selected based on their nomination materials rather than on actual longitudinal evidence. Second, this study's data were gathered through interviews. The authors did not gather data through student work samples, teacher and staff interviews, or other data points, but rather the single data point of principal perspectives through interviews.Originality/valueOne silver lining from the pandemic is that leading schools cannot be detangled from the digital needs of diverse stakeholders. As such, digital principalship has become the new norm where the principal leads on a screen, teachers teach on a screen, and students learn on a screen. The award-winning digital principals in this study played an integral role in how they message their school's story, how they navigate and design structures, how they overcome political realities, and how they invest in addressing the needs of individuals.
Production of 11α‐hydroxysteroids from sterols in a single fermentation step by Mycolicibacterium smegmatis
Authors: Felpeto‐Santero Carmen , Galán Beatriz , García José Luis 
Published: March 2021

Summary11α‐hydroxylated steroid synthons are one of the most important commercially pharmaceutical intermediates used for the production of contraceptive drugs and glucocorticoids. These compounds are currently produced by biotransformation using fungal strains in two sequential fermentation steps. In this work, we have developed by a rational design new recombinant bacteria able to produce 11α‐hydroxylated synthons in a single fermentation step using cholesterol (CHO) or phytosterols (PHYTO) as feedstock. We have designed a synthetic operon expressing the 11α‐hydroxylating enzymes from the fungus Rhizopus oryzae that was cloned into engineered mutant strains of Mycolicibacterium smegmatis that were previously created to produce 4‐androstene‐3,17‐dione (AD), 1,4‐androstadiene‐3,17‐dione (ADD) from sterols. The introduction of the fungal synthetic operon in these modified bacterial chassis has allowed producing for the first time 11αOH‐AD and 11αOH‐ADD with high yields directly from sterols in a single fermentation step. Remarkably, the enzymes of sterol catabolic pathway from M. smegmatis recognized the 11α‐hydroxylated intermediates as alternative substrates and were able to efficiently funnel sterols to the desired hydroxylated end‐products.
Association between benzodiazepine outpatient treatment and risk of early seizure recurrence in emergency patients with seizure: A multicenter retrospective study
Authors: Roussel Melanie , Chauvin Anthony , Le Borgne Pierrick , Drogrey Marie , Eyer Xavier , Hatabian Ulysse , Choquet Christophe , Peyrony Olivier , Luhmann Laura , Kassasseya Christian , Belaud Valentin , Navarro Vincent , Bloom Ben , Montassier Emmanuel , Freund Yonathan 
Published: March 2021

AbstractIntroductionSeizures are one of the most common neurological reasons for emergency department (ED) visits. The benefit of ED‐initiated, short‐course outpatient benzodiazepine (BZD) treatment to prevent early recurrent seizure is unknown. This study assesses the risk of early seizure recurrence in patients who were or were not started with outpatient BZD in the ED.MethodsThis was a multicenter retrospective study conducted in eight French EDs between January 1 and December 31, 2019. All patients admitted for seizure were retrospectively screened and those discharged home from the ED were included. Patients with a history of chronic alcohol intoxication or chronic BZD therapy were excluded. Baseline characteristics, type of seizure, and 30‐day outcome were retrospectively collected from the electronic health records. The primary endpoint was a return visit for seizure recurrence within 30 days. Independent factors associated with a seizure recurrence were identified using a multivariable binary logistic regression.ResultsA total of 2,218 patients were included and 1,820 were analyzed. The median age was 39 years and 60% were men. Among them 82% of patients had a generalized tonic–clonic seizure and 47% of seizures were idiopathic. BZD treatment was started in 773 (42%) patients. A total of 154 (8%) patients had an early recurrence at 30 days: 68 (9%) in patients who were treated with BZD versus 86 (8%) in patients who were not (odds ratio [OR] = 1.07, 95% confidence interval [CI] = 0.71 to 1.43). In multivariable analysis, two factors were independently associated with the primary endpoint: chronic epileptic treatment (adjusted OR = 2.58, 95% CI = 1.55 to 4.37) and having had a focal seizure (adjusted OR = 2.16, 95% CI = 1.56 to 4.37).ConclusionBZD therapy was started in 42% of patients who were discharged home after ED visit for a seizure. This treatment was not an independent factor associated with the risk of return visit for seizure recurrence at 30 days.
Guided endodontics: The impact of new technologies on complex case solution
Authors: Loureiro Marco Antônio Z. , Silva Julio A. , Chaves Gustavo S. , Capeletti Lucas R. , Estrela Carlos , Decurcio Daniel A. 
Published: March 2021

AbstractDiscuss the impact of new diagnostic and planning technologies on the resolution of a clinical case of an upper central incisor with lateral perforation, root canal calcification and apical periodontitis. A 44‐year‐old woman sought treatment because of a colour change in an anterior tooth. The tooth had already been endodontically accessed, and she reported that two different clinicians had failed to locate the root canal. A Cone Beam Computed Tomography scan showed excessive wear and root perforation in the middle third, as well as pulp canal obliteration in the apical third. The perforation was treated using a biomaterial, and the root canal was located using guided endodontics. This treatment protocol was used to access, prepare, medicate with calcium hydroxide for 21 days and fill the root canal. Treatment results were satisfactory at 6‐month follow‐up.
Swiss neonatal caregivers express diverging views on parental involvement in shared decision‐making for extremely premature infants
Authors: Fauchère Jean‐Claude , Klein Sabine D. , Hendriks Manya J. , Baumann‐Hölzle Ruth , Berger Thomas M.B. , Bucher Hans Ulrich ,   the Swiss Neonatal End‐of‐Life Study Group
Published: March 2021

AbstractAimDue to scarce available national data, this study assessed current attitudes of neonatal caregivers regarding decisions on life‐sustaining interventions, and their views on parents' aptitude to express their infant's best interest in shared decision‐making.MethodsSelf‐administered web‐based quantitative empirical survey. All 552 experienced neonatal physicians and nurses from all Swiss NICUs were eligible.ResultsThere was a high degree of agreement between physicians and nurses (response rates 79% and 70%, respectively) that the ability for social interactions was a minimal criterion for an acceptable quality of life. A majority stated that the parents' interests are as important as the child's best interest in shared decision‐making. Only a minority considered the parents as the best judges of what is their child's best interest. Significant differences in attitudes and values emerged between neonatal physicians and nurses. The language area was very strongly associated with the attitudes of neonatal caregivers.ConclusionDespite clear legal requirements and societal expectations for shared decision‐making, survey respondents demonstrated a gap between their expressed commitment to shared decision‐making and their view on parental aptitude to formulate their infant's best interest. National guidelines need to address these barriers to shared decision‐making to promote a more uniform nationwide practice.
“Unlucky punch”: unexpected annular rupture during TAVR and successful treatment
Authors: Geyer Martin , Tamm Alexander , Dohle Daniel‐S. , Kornberger Angela , Schnorbus Boris , Beiras‐Fernandez Andres , Münzel Thomas , von Bardeleben Ralph Stephan 
Published: March 2021

AbstractAlthough rare, annular rupture in TAVR is a feared and often unpredictable complication with relevant impact on in‐hospital prognosis. Severe annular calcification is a common risk factor for annular rupture. We report on a case of annular rupture during TAVR with a balloon‐expanded prosthesis in the absence of any annular calcification in the planning CT scan and illustrate the proposed pathomechanism as well as its successful immediate surgical management.
Monitoring the effects of COVID‐19 in emerging adults with pre‐existing mood and anxiety disorders
Authors: Osuch Elizabeth , Demy Jazzmin , Wammes Michael , Tremblay Paul , Vingilis Evelyn , Carter Chlöe 
Published: March 2021

AbstractAimThe COVID‐19 quarantine closed many mental health services. Emerging adults with pre‐existing mood or anxiety disorders were of concern for worsening symptoms. We sought to demonstrate a method for monitoring mental health status of a group of patients with reduced access to their usual mental health services during quarantine.MethodsA total of 326 patients enrolled in the First‐Episode Mood and Anxiety Program in London, Ontario, Canada were invited to participate in online questionnaires regularly. Patients were flagged for high level of risk based on depression scores, suicidal ideation and worsening in anxiety, depression or quality of health. All patients were also asked if they wanted contact with a clinician.ResultsOne hundred and fourteen (35%) patients completed at least one questionnaire. Thirty were flagged based on scores; 37 (32.5%) participating patients requested help. Participants who were flagged for concerning scores were younger, more likely to be on the wait list for treatment, to have been laid off from work and have more functional impairment. Participants requesting support had higher symptom scores for depression and lower scores on quality of health.ConclusionsThe process utilized here identified patients at risk and in need of clinical support in the context of pandemic quarantine. It provided an accessible avenue for invited patients to communicate both symptom status and need for contact. Such a process can provide valuable monitoring during times when the usual communications between patients and health care providers is compromised and clinician time is limited. It is easily implemented.
Climate‐induced decrease in biomass flow in marine food webs may severely affect predators and ecosystem production
Authors: du Pontavice Hubert , Gascuel Didier , Reygondeau Gabriel , Stock Charles , Cheung William W. L. 
Published: March 2021

AbstractClimate change impacts on marine life in the world ocean are expected to accelerate over the 21st century, affecting the structure and functioning of food webs. We analyzed a key aspect of this issue, focusing on the impact of changes in biomass flow within marine food webs and the resulting effects on ecosystem biomass and production. We used a modeling framework based on a parsimonious quasi‐physical representation of biomass flow through the food web, to explore the future of marine consumer biomass and production at the global scale over the 21st century. Biomass flow is determined by three climate‐related factors: primary production entering the food web, trophic transfer efficiency describing losses in biomass transfers from one trophic level (TL) to the next, and flow kinetic measuring the speed of biomass transfers within the food web. Using climate projections of three earth system models, we calculated biomass and production at each TL on a 1° latitude ×1° longitude grid of the global ocean under two greenhouse gas emission scenarios. We show that the alterations of the trophic functioning of marine ecosystems, mainly driven by faster and less efficient biomass transfers and decreasing primary production, would lead to a projected decline in total consumer biomass by 18.5% by 2090–2099 relative to 1986–2005 under the “no mitigation policy” scenario. The projected decrease in transfer efficiency is expected to amplify impacts at higher TLs, leading to a 21.3% decrease in abundance of predators and thus to a change in the overall trophic structure of marine ecosystems. Marine animal production is also projected to decline but to a lesser extent than biomass. Our study highlights that the temporal and spatial projected changes in biomass and production would imply direct repercussions on the future of world fisheries and beyond all services provided by Ocean.