bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virtual water trade and its implications on water sustainability
Authors: Nishad Shiv Narayan , Kumar Naresh 
Published: September 2021

Abstract
Limited and declining water resources, increasing demand of water resources from different sectors, has posed a major challenge for maintaining water sustainability and thus overall sustainability for a populous and water-scarce country like India. Over extraction and changing climate have put additional pressure to maintain water sustainability. Therefore, there is a need for proper planning of utilization and management of water resources. Recently, virtual water trade has received much attention and become an important tool for balancing the water budget. On the other hand, virtual water trade may also adversely affect the water balance of the exporter's country as well as the economy. Analysis of the virtual water trade with its implications for water resources is missing; hence, there is a need for such analysis that will help in management of water resources. In this study an attempt is made to present a quantitative analysis of the virtual water trade and its implications for water sustainability. For this study, the rice crop is considered only due to its characteristics as rice is a major water consumer crop and water exporter crop from India.
Sediment metals adhering to biochar enhanced phosphorus adsorption in sediment capping
Authors: Gao Cheng , Fan Jie , Zhang Xujie , Gong Zhiwei , Tan Zhenyu 
Published: September 2021

Abstract
Metal ions in sediment are inherent Ca and Fe sources for biochar modification. In this work, the effect of Ca2+ and Fe2+ released from sediment on biochar for phosphorus adsorption was evaluated. Results showed that raw peanut shell biochar (PSB) was poor in phosphorus adsorption (0.48 mg/g); sediment-triggered biochar (S-PSB) exhibited a P adsorption capacity of 1.32 mg/g in capping reactor and maximum adsorption capacity of 10.72 mg/g in the Langmuir model. Sediment released Ca2+ of 2.2–4.1 mg/L and Fe2+/Fe3+ of 0.2–9.0 mg/L. The metals loaded onto the biochar surface in the forms of Ca-O and Fe-O, with Ca and Fe content of 1.47 and 0.29%, respectively. Sediment metals made point of zero charge (pHpzc) of biochar shifted from 5.39 to 6.46. The mechanisms of enhanced P adsorption by S-PSB were surface complexation of CaHPO4 followed by precipitation of Ca3(PO4)2 and Ca5(PO4)3(OH). Sediment metals induced the modification of biochar and improvement of P adsorption, which was feasible to overcome the shortcomings of biochar on phosphorus control in sediment capping.
Carbon Nanoparticles in Mongolian Medicine Alleviate Acute Gastric Ulcer
Induced by Ethanol by Regulating Fas/FasL Pathway
Authors: Chao Du , Chenchen Wang , Xiyue Zhang , Shikui Wu , Yingze Wang 
Published: September 2021

Introduction:
The consumption of large amounts of ethanol can directly lead to acute
gastric mucosal bleeding, edema, and erosion, while long-term drinking has been associated with
gastric ulcers. Previous research has demonstrated that Har Gabur, a traditional Mongolian
medicine, alleviates gastric ulcers through the physical adsorption of its carbon components. It is
well known that the immune response has an important role in gastric ulceration.

Methods:
In the present study, we used an ethanol-induced injury cell and mice model to investigate
whether Har Gabur can inhibit the immune response stimulated by ethanol and identify the active
constituents of Har Gabur involved in this process.

Results:
We found that Har Gabur significantly repressed the activated Fas/FasL signal pathway
and endogenous Bax/Bcl-2 apoptosis pathway. The molecular mechanism of the protective effect
most likely involved the transcription or mRNA stability, as Har Gabur remarkably reversed the
change in mRNA level of apoptosis-related genes induced by ethanol.

Conclusion:
Har Gabur operated in a cell-state-specific manner in vivo without inducing adverse
effects in normal mice. Importantly, GO was identified as the main active ingredient of Har Gabur
for gastric ulcers.
Linalool as a Therapeutic and Medicinal Tool in Depression Treatment: A
Review
Authors: dos Santos Éverton Renan Quaresma , Maia José Guilherme S. , Fontes-Júnior Enéas Andrade , do Socorro Ferraz Maia Cristiane 
Published: September 2021

:
Depression is a prevalent disease worldwide, limiting psychosocial functioning and thequality
of life. Linalool is the main constituent of some essential oils from aromatic plants, representing
about 70% of these volatile concentrates. Evidence of the linalool activity on the central
nervous system, mainly acting as an antidepressant agent, is increasingly abundant. This review
aimed to extend the knowledge of linalool's antidepressant action mechanisms, which is fundamental
for future research, intending to highlight this natural compound as a new antidepressant phytomedication.
A critical analysis is proposed here with probable hypotheses of the synergic mechanisms
that support the evidence of antidepressant effects of the linalool. The literature search has
been conducted in databases for published scientific articles before December 2020, using relevant
keywords. Several pieces of evidence point to the anticonvulsant, sedative, and anxiolytic actions.
In addition to these activities, other studies have revealed that linalool acts on the monoaminergic
and neuroendocrine systems, inflammatory process, oxidative stress, and neurotrophic factors, such
as BDNF, resulting in considerable advances in the knowledge of the etiology of depression. In
this context, linalool emerges as a promising bioactive compound in the therapeutic arsenal, capable
of interacting with numerous pathophysiological factors and acting on several targets. This review
claims to contribute to future studies, highlighting the gaps in the linalool knowledge, such as
its kinetics, doses, routes of administration, and multiple targets of interaction, to clarify its antidepressant
activity.
Utility of 1-(4-Substituted Aminophenyl)Ethanones in Heterocyclic Synthesis
Part (II)
Authors: Gouda Moustafa A. , Salem Mohammed A. , Helal Mohamed H. , Alzahrani Abdullah Y.A. 
Published: September 2021

Abstract:
The improvement of new synthetic routes towards thiophene, oxazole, triazole, pyrimidine,
pyridine, quinolone, coumarin, imidazopyrimidine, pyridoimidazole and triazolo[1,5-a] pyridine
for their biological and medicinal exploration is an appealing vicinity for researchers. This review
focuses on the utility of 1-(4-substituted-aminophenyl) ethanones and their derivatives as critical
intermediates for the synthesis of these systems developed within the closing decade.
Coronavirus Disease 2019 (COVID-19) and Pregnancy: A Narrative Review
Authors: Zafari Mandana , Rad Mohammad Taha Saadati , Mohseni Fatemeh 
Published: September 2021

:
A novel viral respiratory disease caused by severe acute respiratory syndrome, coronavirus
2 (SARS-COV-2), is responsible for a pandemic situation in the world. Pregnant women are
susceptible to this virus due to physiologic changes in the immunologic system. The risk of some
adverse pregnancy outcomes, such as death, stillbirth, preeclampsia, and intrauterine fetal distress,
may increase in infected pregnant women. Infected women should be isolated and investigated,
and they should admit to a designated hospital with adequate facilities and multi-disciplinary expertise
to manage them. Furthermore, the chances of adverse neonatal complications, such as small for
gestational age, large for gestational age, shortness of breath, thrombocytopenia with abnormal liver
function, rapid heart rate, vomiting, and pneumothorax, may increase in an affected neonate.
This study reviews the problems and guidelines of covid-19 in pregnancy.
Association of Large Vessel Aneurysm/Pseudo-Aneurysm/Aortitis and Deep Vein Thrombosis in Patients with Behçet’s Disease: A Case Report
Authors: Shenavandeh Saeedeh , Johari Hamed Ghoddusi , Aflaki Elham 
Published: September 2021

Background:
Behçet’s disease (BD) is a complex vasculitis with some vascular manifestations
including venous thrombosis, arterial thrombosis/aneurysm/pseudoaneurysm, and co-associated
venous thrombosis and arterial lesions. We present two patients with Behçet’s disease came
with progressive both arterial and venous involvement.

Case Presentation:
The first patient was a young man with recurrent oral aphthosis and skin folliculitis
and referred with complaint of new abdominal pain and 2 months severe headache. He had
not referred to a physician due to COVID-19 pandemic until that time. In addition, he gradually developed
a lower extremity edema and eventually was diagnosed with BD complicated with brain
sagittal sinus vein thrombosis, abdominal aortic aneurysms and aortitis and deep vein thrombosis
(DVT) of femoral vein. The second patient was a young woman with previous history of uveitis,
DVT and recurrent oral and genital aphthosis presented with a large inguinal mass due to large iliac
artery pseudoaneurysm impending to rupture, and after the operation, due to poor follow-up, developed
a new femoral DVT.

Conclusion:
It seems the same inflammatory process is responsible for arterial and venous involvement
in patients with BD, so it should be considered that involvement in one side (venous/arterial)
can be a risk factor for the other side (venous/arterial) and early immunosuppressive treatment
should always be considered to improve the prognosis.
The Role of Oxidative Stress, Inflammation, and Advanced Glycation End Product in Skin Manifestations of Diabetes Mellitus
Authors: Legiawati Lili 
Published: September 2021

Abstract:Diabetes mellitus is a metabolic disorder caused by an increase in insulin resistance, a decrease in insulin production, or both of them, resulting in a high level of blood glucose or hyperglycemia. An uncontrolled state of DM may cause complications, namely skin disorder. One or more skin disorders are found amongst 74% of T2DM patients, with the highest percentage is dry skin (47%), followed by infection (10%), diabetic hand (5%), hair loss and diabetic dermopathy (each 4%). In DM, the state of hyperglycemia and production of advanced glycaemic end-products (AGEs) profoundly impact skin changes. In the pathological pathway, AGEs induce oxidative stress and inflammation. Nonetheless, AGEs level is higher in T2DM patients compared to non- T2DM people. This is caused by hyperglycemia and oxidative stress. Binding between AGEs and receptor of AGEs (RAGE) promotes pathway of oxidative stress and inflammation cascade via mitogen- activated protein kinases (MAPK), nuclear factor-k-light-chain-enhancer of activated β cells (NF-kβ), interleukin- 6 (IL-6), tumor necrosis factor-α (TNF-α), expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 2 (VCAM-2) pathway which furtherly effectuates DM complication including skin disorders.
Obesity-Related Communication in Digital Chinese News From Mainland China, Hong Kong, and Taiwan: Automated Content Analysis
Authors: Chang Angela , Schulz Peter Johannes , Jiao Wen , Liu Matthew Tingchi 
Published: September 2021

Background
The fact that the number of individuals with obesity has increased worldwide calls into question media efforts for informing the public. This study attempts to determine the ways in which the mainstream digital news covers the etiology of obesity and diseases associated with the burden of obesity.

Objective
The dual objectives of this study are to obtain an understanding of what the news reports on obesity and to explore meaning in data by extending the preconceived grounded theory.

Methods
The 10 years of news text from 2010 to 2019 compared the development of obesity-related coverage and its potential impact on its perception in Mainland China, Hong Kong, and Taiwan. Digital news stories on obesity along with affliction and inferences in 9 Chinese mainstream newspapers were sampled. An automatic content analysis tool, DiVoMiner was proposed. This computer-aided platform is designed to organize and filter large sets of data on the basis of the patterns of word occurrence and term discovery. Another programming language, Python 3, was used to explore connections and patterns created by the aggregated interactions.

Results
A total of 30,968 news stories were identified with increasing attention since 2016. The highest intensity of newspaper coverage of obesity communication was observed in Taiwan. Overall, a stronger focus on 2 shared causative attributes of obesity is on stress (n=4483, 33.0%) and tobacco use (n=3148, 23.2%). The burdens of obesity and cardiovascular diseases are implied to be the most, despite the aggregated interaction of edge centrality showing the highest link between the “cancer” and obesity. This study goes beyond traditional journalism studies by extending the framework of computational and customizable web-based text analysis. This could set a norm for researchers and practitioners who work on data projects largely for an innovative attempt.

Conclusions
Similar to previous studies, the discourse between the obesity epidemic and personal afflictions is the most emphasized approach. Our study also indicates that the inclination of blaming personal attributes for health afflictions potentially limits social and governmental responsibility for addressing this issue.
TATA LETAK FURNITURE PADA INTERIOR CAFE : STUDI KASUS RUANG CAFE MACAN MARELAN MEDAN
Authors: Atika Juli , Harahap Andriansyah 
Published: September 2021

Cafe macan marelan merupakan tempat hiburan untuk anak muda pada zaman sekarang, cafe ini sangat banyak dikunjungi oleh anak muda, dengan adanya perubahan tata letak cafe macan marelan membuat pengunjung semakin tertarik untuk mengunjungi cafe tersebut, dimana dalam membuat tata letak interior pada cafe ini membuat pengunjung semakin nyaman untuk berkunjung ke cafe macan marelan. Medan merupakan kota kedua terbesar setelah jakarta, sebagai kota medan dengan masyarakat perkantoran trend globalisasi yang membutuhkan adanya cafe di daerah kota medan dalam kehidupan sehari-hari. Lain dari pada itu, waktu menjadi semakin berharga dan kehidupan kota menjadi hiruk pikuk dan bersifat rutin. Sehubung dengan hal itu, manusia menjadi condong untuk mencari hal-hal yang bersifat praktis dalam memenuhi kebutuhannya terhadap pasar untuk hiburan masyarakat, dalam hal ini pembuatan cafe sangat bermanfaat bagi masyarakat yang ada khususnya di marelan city maka dengan adanya perubahan dari tata letak cafe tersebut menjadi kenyamanan bagi para pengunjung cafe serta dapat meningkatkan jumlah pengunjung cafe Macan tersebut.
ANALISIS KARAKTER TOKOH FILM 5 CM SUTRADARA RIZAL MANTOVANI DENGAN KAJIAN SEMIOTIKA
Authors: Darma Surya 
Published: September 2021

Film 5 cm adalah film drama Indonesia, dirilis pada 12 Desember 2012. Film 5 cm disutradarai oleh Rizal Mantovani dengan perusahaan produksi Soraya Intercine Films merupakan adaptasi dari novel 5 cm karya Donny Dhirgantoro. Penelitian ini bertujuan untuk mengetahui makna denotasi, konotasi, dan mitos dalam film 5 cm dengan teori semiotika model Roland Barthes. Objek Penelitian dan Fokus Utama penelitian ini adalah “Analisis Karakter Tokoh Film 5 cm Sutradara Rizal Mantovani dengan Kajian Semiotika”. Sedangkan unit penelitian yaitu analisis karakter tokoh film 5 cm dibedah dengan teori semiotika Roland Barthes. Tahap pemaknaan film 5 cm tidak hanya dilakukan secara denotatif namun juga secara konotatif yaitu sebagai tanda yang muncul pada karakter tokoh pada film 5 cm. Makna tersebut dapat dilihat dalam film 5 cm berdasarkan struktur pembentuk film. Struktur film 5 cm didukung petanda yang dimunculkan pada karakter tokoh. Karakter tokoh film 5 cm yang dianalisis pada penelitian ini yaitu Zafran (Herjunot Ali), Arial (Denny Sumargo), Ian (Saykoji), Riani (Raline Shah), dan Genta (Fedi Nuril). Hasil Analisis Karakter Tokoh Film 5 cm Sutradara Rizal Mantovani dengan Kajian Semiotika yaitu karakter yang ditunjukan dari sosok Arial adalah karakter dengan cowok maskulin, dengan postur tubuh yang proporsional, dan macho, selanjutnya sosok Ian adalah sosok yang humoris, kemudian sosok Arini adalah satu-satunya wanita dalam persahabatan tersebut yang dengan pola pikir dewasa, berjiwa keibuan, dan peduli. Interpretasi dari sosok Genta adalah seorang yang karismatik, bertanggung jawab, pola pikir realistis, dan giat bekerja. Karakter Zafran yaitu seorang yang puitis, humanis, idealis, dan fantastis berdasarkan simbol-simbol yang muncul pada film 5 cm.
ANALISIS PROSES KREATIF PRODUKSI FILM PADA KOMUNITAS FISABILILLAH PRODUCTION (FISPRO) KOTA MEDAN
Authors: Wahyuni Sri , Sya'dian Triadi 
Published: September 2021

Penelitian ini bertujuan untuk menguraikan serta mendeskripsikan strategi kreatif produksi film pada komunitas Fisabilillah Production (Fispro). Fisabilillah Production merupakan komunitas film yang berada di Kota Medan merupakan sebuah komunitas perfilman yang berdomisili di Medan yang berdiri sejak tahun 2015. Komunitas perfilman ini bergerak di bidang dakwah yang bertujuan menciptakan karya dalam bentuk film yang dapat menginspirasi masyarakat serta dapat diterapkan dalam kehidupan sehari – hari. Metode yang digunakan pada penelitian ini yaitu penelitian deskriptif kualitatif. Hasil penelitian proses kreatif yang digunakan pada Komunitas Fispro yaitu pertama berdasarkan rancangan proses pra-produksi melalui ide / tema skenario, casting, reading dan rehearsal. Proses kreatif yang digunakan pada saat produksi dengan menekankan kepada mise-en-scene yaitu : 1) gambar/adegan ; 2) pergerakan pemain dan kamera ; 3) sinematografi ; 4) penataan cahaya ; 5) seting dan properti ; 6) penataan suara ; dan 7) editing. Sedangkan pada saat pasca produksi sendiri sutradara tidak menggunakan strategi-strategi khusus.
PERAN DESAIN BERBANTUAN KOMPUTER (CAD) MAHASISWA JURUSAN DESAIN INTERIOR UNIVERSITAS POTENSI UTAMA
Authors: Sitorus Rizki Hamdani 
Published: September 2021

Tujuan dari tulisan ini adalah untuk menyelidiki peran desain berbantuan computer (Computer-Aided Design (CAD)) dan untuk mengumpulkan informasi umum tentang penggunaan CAD oleh mahasiswa program studi desain interior Universitas Potensi Utama Medan dalam praktik desain interior. Metode penelitian ini adalah metode studi lapangan dan studi literatur. Studi lapangan dilakukan dengan cara memberikan kuesioner ke 50 mahasiswa yang dipilih secara acak pada bulan April 2021. Fokus utama kuesioner adalah pada CAD,metode latihan yang digunakan oleh mahasiswa, dengan pertanyaan yang berkaitan dengan kemampuan CAD dan latar belakang pendidikan mahasiswa. Selain itu, kuesioner menanyakan pertanyaan umum, termasuk jenis CAD yang digunakan, jenis projek yang dilakukan, lama penggunaan CAD, dan metode memperbarui sistem CAD. Sedangkan studi literatur dilakukan dengan cara mencari data-data dari beberapa sumber.
IMPOSSIBLE INTENTIONS
Authors: Buckwalter Wesley , Rose David , Turri John 
Published: September 2021

Abstract
Philosophers are divided on whether it is possible to intend believed-impossible outcomes. Several thought experiments in the action theory literature suggest that this is conceptually possible, though they have not been tested in ordinary social cognition. We conducted three experiments to determine whether, on the ordinary view, it is conceptually possible to intend believed-impossible outcomes. Our findings indicate that participants firmly countenance the possibility of intending believed-impossible outcomes, suggesting that it is conceptually possible to intend to do something that one believes is impossible.
Reduction of admissions for urgent and elective pacemaker implant during the COVID-19 outbreak in Northern Italy
Authors: Dell’Era Gabriele , Colombo Crizia , Forleo Giovanni B. , Curnis Antonio , Marcantoni Lina , Racheli Marco , Sartori Paolo , Notarstefano Pasquale , De Salvia Alberto , Guerra Federico , Ziacchi Matteo , Tondo Claudio , Gandolfi Edoardo , De Vecchi Federica , Mascioli Giosué , Coppolino Aldo , Catuzzo Bruna , Amellone Claudia , Mantica Massimo , D’Ascenzo Fabrizio , Patti Giuseppe 
Published: September 2021

Aims
The coronavirus disease-19 (COVID-19) outbreak has been recently associated with lower hospitalization rates for acute coronary syndromes. Aim of the study was to investigate whether a similar behaviour is observed in admissions for urgent pacemaker implant.

Methods
This retrospective study included 1315 patients from 18 hospitals in Northern Italy with a high number of COVID-19 cases. Hospitalization rates for urgent pacemaker implant were compared between the following periods: 20 February to 20 April 2020 (case period); from 1 January to 19 February 2020 (intra-year control period); from 20 February to 20 April 2019 (inter-year control period).

Results
The incidence rate of urgent implants was 5.0/day in the case period, 6.0/day in the intra-year control period and 5.8/day in the inter-year control period. Incidence rate in the case period was significantly lower than both the intra-year [incidence rate ratio (IRR): 0.81, 95% CI 0.67–0.99, P = 0.040] and inter-year control periods (IRR: 0.79, 95% CI 0.66–0.95, P = 0.012); this reduction was highest after the national lockdown (IRR 0.68, 95% CI 0.52–0.91, P = 0.009). The prevalence of residents in rural areas undergoing urgent pacemaker implant was lower in the case period (36%) than in both the intra-year (47%, P = 0.03) and inter-year control periods (51%, P = 0.002). Elective pacemaker implants also decreased in the case period, with the incidence rate here being 3.5/day vs. 6.4/day in the intra-year (−45%) and 6.9/day in the inter-year period (−49%).

Conclusion
Despite severe clinical patterns, the COVID-19 outbreak has negatively affected the population presentation to Emergency Departments for bradyarrhythmias requiring urgent pacemaker implant in Northern Italy. This mainly occurred after the national lockdown and concerned patients living in rural areas.
RACISMO ESTRUTURAL E SEUS REFLEXOS NAS CORPORAÇÕES: O PAPEL DAS POLÍTICAS DE COMPLIANCE NA LUTA ANTIRRACISTA E A NECESSÁRIA MUDANÇA CULTURAL
Authors: Baqueiro Fernanda Ravazzano Lopes , Cezar Silvia Monique Santos 
Published: September 2021

<div><p>Trata-se de artigo que objetiva analisar a contribuição das políticas de <em>compliance<strong> </strong></em>para a promoção da necessária mudança cultural no abandono das heranças seculares racistas que permeiam a sociedade brasileira. Com efeito, busca-se abordar, inicialmente, o racismo estrutural, na perspectiva histórica e como está enraizado e se espraia nas relações sociais até os dias atuais. Em seguida, analisa-se o que são as políticas de <em>compliance</em>, desde sua origem, perpassando pela compreensão de que os programas de conformidade não se limitam às questões econômicas da pessoa jurídica, mas a todas as relações por ela travadas, sobretudo com seus <em>stakeholders</em>, para, ao final, questionar em que medida o <em>compliance </em>pode ser importante ferramenta na luta antirracista e na promoção da justiça social. Para tanto foi empregado o método hermenêutico, com a releitura de obras e artigos científicos, nacionais e estrangeiros, com abordagem qualitativa.</p><p> </p></div>