bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distribution and diversity of meiofauna along an aquatic-terrestrial moss ecotone
Authors: Kreuzinger-Janik Bianca , Majdi Nabil , Traunspurger Walter 
Published: February 2021

Summary
This study provides first insights into the moss-dwelling meio-invertebrate community inhabiting mosses collected from underwater, splash-water and adjacent terrestrial habitats along a Swedish lake. Additionally, changes in both species and functional diversity of the nematode community were followed. Total meio-invertebrate mean densities and biomass peaked at 10 644.2 ± 2391.8 individuals (g dry weight (DW) moss)−1 and 14 199.3 ± 5037.3 μg DW (g DW moss)−1 underwater, 1 m away from the shoreline, where the community was strongly dominated by rotifers, followed by nematodes. Total invertebrate biomass in terrestrial mosses was much lower, indicative of a significantly higher carrying capacity of moss patches in aquatic environments, which provide a high level of resource turnover as well as a buffer against desiccation and extreme temperature fluctuations. We found a total of 74 nematode species and maximum diversity was attained 1 m away from the shoreline and at the splash-water zone. The underwater mosses at the shoreline thus housed the most diverse and abundant assemblages of meio-invertebrates, suggesting they may play an important ecological role at the land-water interface. Evidenced by the multiple shifts in dominance, our study clearly showed that feeding types differed between habitats. The taxonomic and functional segregation of the nematode community along the ecotone further indicated that the composition of nematode species assemblages has the potential to mirror the ecological changes of the study site, even at small scales.
Building up Oneself as an Ascetic in the Shadow of Devotional Artifacts: The Case of the malañg-fuqarā of Pakistan
Authors: Ortis Delphine 
Published: February 2021

Abstract
This essay presents a reflection on the building process of ascetics belonging to an order “outside religious law” (be sharʿ), the Qalandarī, through the case of the malañg-fuqarā of a Pakistani Sufi lodge. I hypothesize that being an ascetic is a form of technique of the body and the subject, which results in producing, configuring, and using them, in relation to the Sufi and Twelver Shiʿism artifacts dispensing the healing and miraculous potency of the saint to whom he dedicates his life, and through which he builds himself as potential saint.
Energy Flow Diagnosis of ENSO from an Ocean Reanalysis
Authors: Toyoda Takahiro , Nakano Hideyuki , Aiki Hidenori , Ogata Tomomichi , Fukutomi Yoshiki , Kanno Yuki , Urakawa L. Shogo , Sakamoto Kei , Yamanaka Goro , Nagura Motoki 
Published: February 2021

AbstractA method is introduced for diagnosing the time evolution of wave energy associated with ENSO from an ocean reanalysis. In the diagnosis, time changes of kinetic and available potential energy are mainly represented by energy inputs caused by surface wind stress and horizontal energy fluxes for each vertically decomposed normal mode. The resulting time evolutions of the wave energy and vertical thermocline displacements in the 1997/98 and 2014–16 El Niño events are consistent with our previous knowledge of these events. Further, our result indicated that representation of several vertical modes is necessary to reproduce the broadly distributed downward thermocline displacements in the central to eastern equatorial Pacific, generated by a westerly wind event in the western equatorial Pacific (e.g., in March 1997), that are preconditioning for El Niño development. In addition, we investigated the wave energy budget, including the influence of data assimilation, on the complicated time evolution of equatorial thermocline displacements caused by repeated westerly and easterly wind events during the 2014–16 El Niño event. Our result suggests that noise from a momentum imbalance near the equator associated with data assimilation, which possibly affected the El Niño prediction failure in 2014, was much reduced by our developed ocean data assimilation system and reanalysis. This study, which provides a new connection between the theoretical works and reanalysis products that use sophisticated systems for synthesizing OGCMs and observations, should be useful for climate research and operational communities interested in ENSO.
An Assessment of Land–Atmosphere Interactions over South America Using Satellites, Reanalysis, and Two Global Climate Models
Authors: Baker Jessica C. A. , Castilho de Souza Dayana , Kubota Paulo Y. , Buermann Wolfgang , Coelho Caio A. S. , Andrews Martin B. , Gloor Manuel , Garcia-Carreras Luis , Figueroa Silvio N. , Spracklen Dominick V. 
Published: February 2021

AbstractIn South America, land–atmosphere interactions have an important impact on climate, particularly the regional hydrological cycle, but detailed evaluation of these processes in global climate models has been limited. Focusing on the satellite-era period of 2003–14, we assess land–atmosphere interactions on annual to seasonal time scales over South America in satellite products, a novel reanalysis (ERA5-Land), and two global climate models: the Brazilian Global Atmospheric Model version 1.2 (BAM-1.2) and the U.K. Hadley Centre Global Environment Model version 3 (HadGEM3). We identify key features of South American land–atmosphere interactions represented in satellite and model datasets, including seasonal variation in coupling strength, large-scale spatial variation in the sensitivity of evapotranspiration to surface moisture, and a dipole in evaporative regime across the continent. Differences between products are also identified, with ERA5-Land, HadGEM3, and BAM-1.2 showing opposite interactions to satellites over parts of the Amazon and the Cerrado and stronger land–atmosphere coupling along the North Atlantic coast. Where models and satellites disagree on the strength and direction of land–atmosphere interactions, precipitation biases and misrepresentation of processes controlling surface soil moisture are implicated as likely drivers. These results show where improvement of model processes could reduce uncertainty in the modeled climate response to land-use change, and highlight where model biases could unrealistically amplify drying or wetting trends in future climate projections. Finally, HadGEM3 and BAM-1.2 are consistent with the median response of an ensemble of nine CMIP6 models, showing they are broadly representative of the latest generation of climate models.
The Vice and Virtue of Increased Horizontal Resolution in Ensemble Forecasts of Tornadic Thunderstorms in Low-CAPE, High-Shear Environments
Authors: Lawson John R. , Potvin Corey K. , Skinner Patrick S. , Reinhart Anthony E. 
Published: February 2021

AbstractTornadoes have Lorenzian predictability horizons O(10) min, and convection-allowing ensemble prediction systems (EPSs) often provide probabilistic guidance of such events to forecasters. Given the O(0.1)-km length scale of tornadoes and O(1)-km scale of mesocyclones, operational models running at horizontal grid spacings (Δx) of 3 km may not capture narrower mesocyclones (typical of the southeastern United States) and certainly do not resolve most tornadoes per se. In any case, it requires O(50) times more computer power to reduce Δx by a factor of 3. Herein, to determine value in such an investment, we compare two EPSs, differing only in Δx (3 vs 1 km), for four low-CAPE, high-shear cases. Verification was grouped as 1) deterministic, traditional methods using pointwise evaluation, 2) a scale-aware probabilistic metric, and 3) a novel method via object identification and information theory. Results suggest 1-km forecasts better detect storms and any associated rapid low- and midlevel rotation, but at the cost of weak–moderate reflectivity forecast skill. The nature of improvement was sensitive to the case, variable, forecast lead time, and magnitude, precluding a straightforward aggregation of results. However, the distribution of object-specific information gain over all cases consistently shows greater average benefit from the 1-km EPS. We also reiterate the importance of verification methodology appropriate for the hazard of interest.
Eye Tracking to Evaluate the Effects of Interruptions and Workload in a Complex Task
Authors: Kanaan Dina , Moacdieh Nadine Marie 
Published: February 2021

Objective To use eye tracking to understand the effects of interruptions in different workload conditions as part of a monitoring and change detection task. Background Interruptions are detrimental to performance in complex, multitasking domains. There is a need for better display design techniques that help users overcome interruptions regardless of their workload level. This requires understanding a user’s attentional state immediately after an interruption in order to determine what type of display adjustments are most suitable. Method An emergency dispatching simulator was developed with a visual primary task and auditory interruptive task. Two levels of workload were induced by varying the number of emergency vehicles to monitor for changes and the rate of changes to monitor. Eye tracking, performance, and subjective measures (NASA-Task Load Index) were collected and analyzed for 41 participants. Results As expected, high workload interacted with interruptions to further degrade primary task performance and alter participants’ attention allocation immediately after the interruption. Participants in the high workload condition had more narrowed, slower scan patterns immediately after the interruption as compared to before the interruption, as evidenced by lower scanpath length per second and mean saccade amplitude. However, this change was not observed in low workload. Conclusion High workload modulates the effects of interruptions on performance and eye movements. Users in the high workload condition struggle to quickly scan the display in the seconds following an interruption. Application The results can provide insight into the type of display adjustments needed right after an interruption in a high-workload environment.
Superselective prostatic artery embolization in the treatment of large benign prostatic hyperplasia
Authors: Neymark Alexander Izrailevich , Karpenko Andrey Anatoljevich , Neymark Boris Alexandrovich , Tachalov Mikhail Alexandrovich , Arzamastsev Denis Dmitrievich , Torbik Demid Vjacheslavovich , Gameeva Elena Vladimirovn , Bobrov Boris Yuryevich , Spivak Leonid Grigoryevich , Korolev Dmitry Olegovich , Tsarichenko Dmitry Georgievich , Rapoport Leonid Moiseevich 
Published: February 2021

Purpose: To evaluate the use of prostatic artery embolization (PAE) as a treatment option for patients with symptomatic benign prostatic hyperplasia (BPH) with prostate volumes of 80 cc and more. Materials and Methods: The study included 75 patients with high anesthesia-related risks for conventional surgery (TURP). All patients were surveyed for symptom burden, using IPSS and quality of life score. The prostate volume was determined by transrectal ultrasonography (TRUS). At baseline, prostate-specific antigen (PSA) level was obtained in all patients. Urodynamics was evaluated using uroflowmetry. Clinical outcomes were assessed at follow-up 1, 3, 6, 12, and 24 months after PAE. Results: The prostate volume decreased significantly at months 1 and 3 post-treatment; the prostate continued shrinking until month 12, and the size was then stabilized. At month 24, prostate volume decreased by 40.82%, from 134.0 ± 8.3 mL at baseline to 79.3 ± 6.6 mL. Postvoid residual (PVR) urine volume was significantly decreased from 55.9 ± 5.3 mL to 22.0 ± 1.8 mL 1 month after PAE ( p < 0.001). Qmax increased from 9.2 ± 0.3 mL/s to 15.7 ± 0.4 mL/s. IPSS score following PAE decreased from 28.2 ± 0.7 to 9.7 ± 0.8 ( p < 0.001). QoL improvement was observed from 4.8 ± 0.2 at baseline to 1.8 ± 0.2 at month 24 ( p < 0.001). Decreased activity and density of adenomatous tissue resulted in decreased total PSA levels: from 5.9 ± 1.1 ng/mL to 2.6 ± 0.2 ng/mL ( p < 0.001). TURP became feasible in 35 patients due to reduction of prostate volumes below 80 mL after PAE. Conclusions: PAE was effective in relieving LUTS and reducing prostate size, and may be considered as a preoperative approach for patients with large prostate.
Improving Limb Salvage for Chronic Limb-Threatening Ischemia With Spinal Cord Stimulation: A Retrospective Analysis
Authors: Cyrek Anna E. , Henn Nora , Meinhardt Fabian , Lainka Martin , Pacha Arkadius , Paul Andreas , Koch Dietrich 
Published: February 2021

Introduction: Chronic limb-threatening ischemia (CLTI) represents the most severe form of peripheral artery disease (PAD). Up to a third of CLTI patients are not eligible to receive first-line treatments such as bypass surgery or endovascular interventions. Epidural spinal cord stimulation (SCS) has been used as a method to improve microcirculatory blood flow and relieve ischemic pain in CTLI patients. The aim of the study was to evaluate limb salvage, ulcer closure, and clinical changes of SCS implanted CTLI patients at 1-year follow-up. Methods: Eligible patients had end-stage lower limb PAD unresponsive to medical therapy and not amenable to surgical reconstruction. Patients were candidates for amputation, but limb loss was not inevitable (Fontaine stage III and IV). Pain intensity and skin temperature in the ischemic area (visual analogue scale), quality of life (WHOQoL-BREF), and ankle/brachial blood pressure index (ABI) were recorded at routine follow-up visits. Data were analyzed retrospectively. Results: 29 patients underwent SCS implantation at one vascular center. The minimum follow-up period was 30 months. Limb survival at 1-year follow-up was 97% (28/29) and 73% (11/15) had complete closure of limb ulcers. Pain intensity, skin temperature, and quality of life progressively improved up to 12 months after implant, with Fontaine stage III patients improving more substantially than Fontaine stage IV patients. SCS therapy did not affect ABI measurement. No complications related to the device or procedure occurred. Conclusions: SCS is a valid alternative in patients unsuitable for revascularization. The quality of results depends on both a strict selection of patients by vascular specialists and the frequency of follow-up controls. The therapy may be more beneficial in patients classified as Fontaine stage III.
Assessing the usability of complex psychosocial interventions: The Intervention Usability Scale
Authors: Lyon Aaron R , Pullmann Michael D , Jacobson Jedediah , Osterhage Katie , Al Achkar Morhaf , Renn Brenna N , Munson Sean A , Areán Patricia A 
Published: February 2021

Background: Usability—the extent to which an intervention can be used by specified users to achieve specified goals with effectiveness, efficiency, and satisfaction—may be a key determinant of implementation success. However, few instruments have been developed to measure the design quality of complex health interventions (i.e., those with several interacting components). This study evaluated the structural validity of the Intervention Usability Scale (IUS), an adapted version of the well-established System Usability Scale (SUS) for digital technologies, to measure the usability of a leading complex psychosocial intervention, Motivational Interviewing (MI), for behavioral health service delivery in primary care. Prior SUS studies have found both one- and two-factor solutions, both of which were examined in this study of the IUS. Method: A survey administered to 136 medical professionals from 11 primary-care sites collected demographic information and IUS ratings for MI, the evidence-based psychosocial intervention that primary-care providers reported using most often for behavioral health service delivery. Factor analyses replicated procedures used in prior research on the SUS. Results: Analyses indicated that a two-factor solution (with “usable” and “learnable” subscales) best fit the data, accounting for 54.1% of the variance. Inter-item reliabilities for the total score, usable subscale, and learnable subscale were α = .83, α = .84, and α = .67, respectively. Conclusion: This study provides evidence for a two-factor IUS structure consistent with some prior research, as well as acceptable reliability. Implications for implementation research evaluating the usability of complex health interventions are discussed, including the potential for future comparisons across multiple interventions and provider types, as well as the use of the IUS to evaluate the relationship between usability and implementation outcomes such as feasibility. Plain language abstract: The ease with which evidence-based psychosocial interventions (EBPIs) can be readily adopted and used by service providers is a key predictor of implementation success, but very little implementation research has attended to intervention usability. No quantitative instruments exist to evaluate the usability of complex health interventions, such as the EBPIs that are commonly used to integrate mental and behavioral health services into primary care. This article describes the evaluation of the first quantitative instrument for assessing the usability of complex health interventions and found that its factor structure replicated some research with the original version of the instrument, a scale developed to assess the usability of digital systems.
Identification of MALT1 feedback mechanisms enables rational design of potent antilymphoma regimens for ABC-DLBCL
Authors: Fontan Lorena , Goldstein Rebecca , Casalena Gabriella , Durant Matthew , Teater Matthew R. , Wilson Jimmy , Phillip Jude , Xia Min , Shah Shivem , Us Ilkay , Shinglot Himaly , Singh Ankur , Inghirami Giorgio , Melnick Ari 
Published: February 2021

Abstract
MALT1 inhibitors are promising therapeutic agents for B-cell lymphomas that are dependent on constitutive or aberrant signaling pathways. However, a potential limitation for signal transduction–targeted therapies is the occurrence of feedback mechanisms that enable escape from the full impact of such drugs. Here, we used a functional genomics screen in activated B-cell–like (ABC) diffuse large B-cell lymphoma (DLBCL) cells treated with a small molecule irreversible inhibitor of MALT1 to identify genes that might confer resistance or enhance the activity of MALT1 inhibition (MALT1i). We find that loss of B-cell receptor (BCR)- and phosphatidylinositol 3-kinase (PI3K)-activating proteins enhanced sensitivity, whereas loss of negative regulators of these pathways (eg, TRAF2, TNFAIP3) promoted resistance. These findings were validated by knockdown of individual genes and a combinatorial drug screen focused on BCR and PI3K pathway–targeting drugs. Among these, the most potent combinatorial effect was observed with PI3Kδ inhibitors against ABC-DLBCLs in vitro and in vivo, but that led to an adaptive increase in phosphorylated S6 and eventual disease progression. Along these lines, MALT1i promoted increased MTORC1 activity and phosphorylation of S6K1-T389 and S6-S235/6, an effect that was only partially blocked by PI3Kδ inhibition in vitro and in vivo. In contrast, simultaneous inhibition of MALT1 and MTORC1 prevented S6 phosphorylation, yielded potent activity against DLBCL cell lines and primary patient specimens, and resulted in more profound tumor regression and significantly improved survival of ABC-DLBCLs in vivo compared with PI3K inhibitors. These findings provide a basis for maximal therapeutic impact of MALT1 inhibitors in the clinic, by disrupting feedback mechanisms that might otherwise limit their efficacy.
RUNX-1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells
Authors: Estevez Brian , Borst Sara , Jarocha Danuta , Sudunagunta Varun , Gonzalez Michael , Garifallou James , Hakonarson Hakon , Gao Peng , Tan Kai , Liu Paul , Bagga Sumedha , Holdreith Nicholas , Tong Wei , Speck Nancy , French Deborah L. , Gadue Paul , Poncz Mortimer 
Published: February 2021

AbstractPatients with familial platelet disorder with a predisposition to myeloid malignancy (FPDMM) harbor germline monoallelic mutations in a key hematopoietic transcription factor, RUNX-1. Previous studies of FPDMM have focused on megakaryocyte (Mk) differentiation and platelet production and signaling. However, the effects of RUNX-1 haploinsufficiency on hematopoietic progenitor cells (HPCs) and subsequent megakaryopoiesis remains incomplete. We studied induced pluripotent stem cell (iPSC)–derived HPCs (iHPCs) and Mks (iMks) from both patient-derived lines and a wild-type (WT) line modified to be RUNX-1 haploinsufficient (RUNX-1+/−), each compared with their isogenic WT control. All RUNX-1+/− lines showed decreased iMk yield and depletion of an Mk-biased iHPC subpopulation. To investigate global and local gene expression changes underlying this iHPC shift, single-cell RNA sequencing was performed on sorted FPDMM and control iHPCs. We defined several cell subpopulations in the Mk-biased iHPCs. Analyses of gene sets upregulated in FPDMM iHPCs indicated enrichment for response to stress, regulation of signal transduction, and immune signaling-related gene sets. Immunoblot analyses in FPDMM iMks were consistent with these findings, but also identified augmented baseline c-Jun N-terminal kinase (JNK) phosphorylation, known to be activated by transforming growth factor-β1 (TGF-β1) and cellular stressors. These findings were confirmed in adult human CD34+-derived stem and progenitor cells (HSPCs) transduced with lentiviral RUNX1 short hairpin RNA to mimic RUNX-1+/−. In both iHPCs and CD34+-derived HSPCs, targeted inhibitors of JNK and TGF-β1 pathways corrected the megakaryopoietic defect. We propose that such intervention may correct the thrombocytopenia in patients with FPDMM.