bluuebunny/crossref_metadata_2025_split huggingface dataset:
Xenon analgesia in children with extensive wounds
Authors: Bagaev V. G. , Rauschenbach N. G. , Mitish V. A. , Medinsky P. V. , Amcheslavsky V. G. , Kolesnik I. V. , Lukyanov V. I. , Bagaeva Yu. V. , Dvornikova M. A. 
Published: October 2021

Purpose. To assess the effectiveness of sub-narcotic concentrations of xenon in the local treatment of extensive wounds in children with severe injuries.Material and methods. 14 patients (average age 9.3 ± 4.0 years) with extensive wounds were taken into the trial. 67 dressings in them were done with 30 % xenon and oxygen. Pain intensity was assessed by the numerical rating scale of pain (NRSp) (1–10 points); sedation depth – by Ramsay scale (1–6 points) and BIS index.Results. Inhalations of 30 % xenon with oxygen during wound dressings reduced the intensity of pain from Me 3.67 (1.2; 6.0) to Me 2.0 (1.0; 3.3) points by NRSp scale (p < 0.05); after sedanalgesia, it increased again to Me 3.0 (1.0; 5.3). Analgesia with 30 % xenon was effective in 55 (82.0 %) dressings; in 8 (11.9 %) patients with trauma, xenon concentration was increased to 50 %, and in 4 (5.9 %) cases 50 % xenon was added with Fentanyl 1–2 mcg/kg. The depth of sedation assessed by the Ramsay scale decreased (p < 0.05) from 6.0 (5.6; 6.0) to 3.1 (2.2; 4.5) points; after sedanalgesia it increased to Me 5.0 (4.5; 5.4) points. At the same time, the mean value of BIS index decreased (p < 0.05) from 97.5 ± 1.5 to 86.5 ± 5.0 U; after dressing, it rapidly increased to 93.0 ± 2.1 U. During dressings, 82 % of children were calm, had contact with a doctor. Afterwards, their sleep was restored, their mood improved.Conclusion. Sedanalgesia with xenon in sub-narcotic concentrations is an effective technique to relieve pain during treatment of extensive wounds in children.
Asthma Phenotypes and Host Risk Factors Associated With Various Asthma-Related Outcomes in Health Workers
Authors: Mwanga Hussein H. , Baatjies Roslynn , Singh Tanusha , Jeebhay Mohamed F. 
Published: October 2021

Background: Work-related asthma phenotypes in health workers (HWs) exposed to cleaning agents have not been investigated extensively as other occupational exposures. This study aimed to describe asthma phenotypes and to identify important host risk factors associated with various asthma-related outcomes.Methods: A cross-sectional study of 699 HWs was conducted in two large tertiary hospitals. A total of 697 HWs completed questionnaire interviews. Sera collected from 682 HWs were analyzed for atopy (Phadiatop) and IgE to occupational allergens (NRL—Hev b5, Hev b6.02; chlorhexidine and ortho-phthalaldehyde—OPA). Methacholine (MCT), bronchodilator challenge (BDR) and fractional exhaled nitric oxide (FeNO) were performed. An asthma symptom score (ASS) used five asthma-related symptoms reported in the past 12 months. Current asthma was based on use of asthma medication or an asthma attack or being woken up by an attack of shortness of breath in the past 12 months. Nonspecific bronchial hyperresponsiveness (NSBH) was defined as having either a positive MCT or a significant bronchodilator response. Two continuous indices of NSBH [continuous index of responsiveness (CIR) and dose-response slope (DRS)] were calculated.Results: The prevalence of current asthma was 10%, atopic asthma (6%) and non-atopic asthma (4%). Overall, 2% of subjects had work-related asthma. There was a weak positive association between NSBH and FeNO [CIR: Beta coefficient (β) = 0.12; CI: 0.03–0.22 and DRS: β = 0.07; CI: 0.03–0.12]. Combining FeNO ≥ 50 ppb with a BDR [mean ratio (MR) = 5.89; CI: 1.02–34.14] or with NSBH (MR = 4.62; CI: 1.16–18.46) correlated better with ASS than FeNO alone (MR = 2.23; CI: 1.30–3.85). HWs with current asthma were twice as likely to be atopic. FeNO was positively associated with atopy (OR = 3.19; CI: 1.59–6.39) but negatively associated with smoking status (GMR = 0.76; CI: 0.62–0.94). Most HWs sensitized to occupational allergens were atopic.Conclusion: Atopic asthma was more prevalent than non-atopic asthma in HWs. Most asthma-related outcomes were positively associated with allergic predictors suggesting a dominant role for IgE mechanisms for work-related symptoms and asthma associated with sensitization to OPA or chlorhexidine.
Dose–Response Relationship Between Physical Activity and the Incidence of Peripheral Artery Disease in General Population: Insights From the National Health and Nutrition Examination Survey 1999–2004
Authors: Qu Cheng-Jia , Teng Le-Qun , Liu Xin-Nong , Zhang Yong-Bao , Fang Jie , Shen Chen-Yang 
Published: October 2021

Purpose: A low ABI, ≦0.9, indicates peripheral artery disease (PAD) and physical activity (PA) represents an important non-surgical treatment for patients with PAD. However, as for the general population, the associations between PA, PAD, and their mutual dependence are not well-defined. Here we aimed to determine whether there is a dose–response relationship between PA and incidence of PAD in the general population using restricted cubic spline (RCS).Patients and methods: This study analyzed 1,370 adults aged ≧40 years who had participated in the National Health and Nutrition Examination Survey (NHANES) during 1999–2004. The ABI of the participants were measured by trained technicians, and PAD was defined as ABI ≦0.9. PA was obtained with a standard questionnaire, and metabolic equivalents (MET) were used to quantify the PA level. Logistic regression was used to assess the association between PA and incidence of PAD, and the dose–response relationship was analyzed with RCS.Results: PAD was present in 6.2% of the participants: 5.6% of males and 6.9% of females. After adjusting for potential confounders, compared with the first quartile (Q1) of MET, the odds ratios (ORs) of PAD for those with Q2, Q3, and Q4 of MET were 0.688 [95% confidence interval (CI) = 0.684–0.692], 0.463 (95% CI = 0.460–0.466), 0.816 (95% CI = 0.812–0.821), respectively (all p &lt; 0.0001). The RCS regression showed that physical activity was related to the incidence of PAD in a non-linear manner (p for non-linearity &lt; 0.0001). For females, the prevalence of PAD decreased as physical activity increased, reaching the minimum for activity at ~5,800 MET-min month−1 (OR = 0.425, 95% CI = 0.424–0.426), and for males, no plateau was found in this study.Conclusion: The prevalence of PAD is inversely associated with PA, and vigorous activities might help decrease PAD risk for general population. The prevalence of PAD reaches the minimum at ~5,800 MET-min month−1, representing a recommended PA value.
A Scoping Review to Assess Sexual and Reproductive Health Outcomes, Challenges and Recommendations in the Context of Climate Migration
Authors: van Daalen Kim Robin , Dada Sara , Issa Rita , Chowdhury Maisoon , Jung Laura , Singh Lucy , Stokes Diarmuid , Orcutt Miriam , Singh Neha S. 
Published: October 2021

Background: As growing numbers of people may be forced to migrate due to climate change and variability, it is important to consider the disparate impacts on health for vulnerable populations, including sexual and reproductive health (SRH). This scoping review aims to explore the relationship between climate migration and SRH.Methods: We searched PubMed/MEDLINE, CINAHL Plus, EMBASE, Web of Science, Scopus, Global Health and Google for peer-reviewed and gray literature published before 2nd July 2021 in English that reported on SRH in the context of climate migration. Data were extracted using a piloted extraction tool and findings are reported in a narrative synthesis.Results: We screened 1,607 documents. Ten full-text publications were included for analysis: five peer-reviewed articles and five gray literature documents. Reported SRH outcomes focused on maternal health, access to family planning and antiretroviral therapy, sexual and gender-based violence, transactional sex, and early/forced marriage. Recommendations to improve SRH in the context of climate migration called for gender-transformative health systems, education and behavior change programmes, and the involvement of local women in policy planning and programme implementation.Discussion: While the disparate impacts of climate change and migration are well-established, primary data on the scope of impact due to climate migration is limited. The SRH outcomes reported in the literature focus on a relatively narrow range of SRH domains, emphasizing women and girls, over men. Achieving holistic and equitable SRH in the context of climate migration requires engaging all genders across the range of SRH outcomes and migration contexts. This review highlights the need for further empirical evidence on the effect of climate migration on SRH, with research that is context-specific and engages communities in order to reflect the heterogeneity of outcomes and impact in the climate-migration-SRH nexus.
Pampasul: uma experiência inovadora nas simulações internacionais
Authors: Xavier Schutz Nathaly , Rizzi Kamilla 
Published: October 2021

O projeto de extensão PAMPASUL – Unipampa Simulações Internacionais consiste na organização de um evento anual de simulação de organismos internacionais, cujo objetivo é promover um amplo espaço para discussões sobre temas relevantes da agenda internacional. São organizadas sessões simuladas de um organismo internacional (OI), sendo que cada sessão representa um comitê de organizações internacionais da periferia do sistema mundial. DOI: https://doi.org/10.35700/ca.2019.ano6n11.p94-98.2671
Profil Kemampuan Penalaran Calon Guru Matematika Ditinjau Dari Jenis Kelamin Dan Pengetahuan Awal
Authors: Khaerunnisa Etika 
Published: October 2021

Capaian pembelajaran lulusan sarjana pada kurikulum berbasis KKNI menunjukkan keselarasan dengan indikator kemampuan penalaran. Hal ini menunjukkan bahwa mahasiswa perlu memiliki kemampuan penalaran dalam setiap proses pembelajaran, telebih mahasiswa calon guru, mengingat mahasiswa jurusan pendidikan matematika kelak akan menjadi guru profesional yang dituntut mampu mengidentifikasi dan meningkatkan kemampuan penalaran siswanya di sekolah. Sehingga perlu dilakukan antisipasi sejak dini bagi calon guru matematika yang kelak menjadi guru dengan cara mengetahui profil kemampuan penalaran dirinya, berdasarkan profil tersebut mahasiswa dapat melakukan evaluasi diri terhadap keunggulan dan kelemahan pada tiap indikator kemampuan penalaran. Tujuan penelitian ini yaitu mendeskripsikan profil kemampuan penalaran calon guru laki-laki dan perempuan kategori pengetahuan awal (tinggi, sedang, rendah). Metode yang digunakan dalam penelitian ini adalah metode kualitatif. Subyek penelitian berdasarkan nilai tes pengetahuan awal dan jenis kelamin yang dikelompokkan dalam enam kategori. Instrumen penelitian terdiri dari soal tes penalaran sebanyak. Hasil penelitian menunjukkan bahwa pada indikator kemampuan mengajukan dugaan, dapat dicapai dengan kriteria mampu oleh calon guru laki-laki kategori tinggi dan kategori rendah serta perempuan kategori tinggi dan rendah. Pada indikator kemampuan melakukan manipulasi matematika dengan kriteria mampu hanya dicapai oleh calon guru perempuan kategori tinggi. Pada indikator kemampuan memberikan alasan terhadap beberapa solusi, hanya dapat dicapai dengan kriteria kurang mampu oleh laki-laki kategori tinggi dan sedang serta perempuan kategori tinggi, sedangkan untuk kriteria tidak mampu dicapai oleh laki-laki kategori rendah dan perempuan kategori sedang dan rendah. Pada indikator kemampuan memeriksa kesahihan suatu argumen dapat dicapai dengan kriteria mampu oleh calon guru laki-laki kategori tinggi dan sedang, serta perempuan kategori tinggi, sedang, rendah. Pada indikator kemampuan menarik kesimpulan atau melakukan generalisasi, keenam kategori calon guru ada pada kriteria kurang mampu dalam menarik kesimpulan.
Analisis Kesalahan Siswa dalam Menyelesaikan Soal Pada Materi SPLDV Ditinjau dari Indikator Kemampuan Matematis
Authors: Ferdianto Ferry , Yesino Leonardus 
Published: October 2021

Penelitian ini bertujuan untuk mengetahui jenis dan penyebab kesalahan siswa dalam menyelesaikan soal pada materi SPLDV yang ditinjau dari indikator kemampuan matematis. Populasi dalam penelitian ini adalah siswa kelas XI SMA Negeri 1 Kadugede Tahun Pelajaran 2017/2018. Pemilihan sampel dengan cara quota sampling, diperoleh siswa kelas XI sebanyak 36 orang. Pengambilan data diperoleh dengan menggunakan metode tes untuk menentukan kemampuan pemecahan masalah matematis siswa yang kemudian dianalisis dengan uji perbedaan rata-rata. Hasil penelitian menunjukan bahwa: 1) Kesalahan dalam memahami masalah sebesar 43,1% 2) Kesalahan dalam merencanakan penyelesaian dan menyelesaikan masalah sesuai rencana sebesar 53,3% 3) Kesalahan dalam menyelesaikan masalah sesuai rencana sebesar 39,8% 4) Kesalahan dalam membuat model matematika, menyelesaikan dan melakukan pengecekan jawaban sebesar 61.1%.
Мукомольные свойства озимых сортов зерна тритикале
Authors: Кандроков Роман Хажсетович , Панкратов Георгий Несторович , Рындин Александр Алексеевич , Конорев Павел Матвеевич 
Published: October 2021

Использование в различных отраслях пищевой и перерабатывающей промышленности продуктов переработки нетрадиционной зерновой культуры - тритикале в настоящее время привлекает все большее внимание, как производителей зерна, так ученых в нашей стране и за рубежом. Обусловлено это обстоятельство увеличением посевных площадей, созданием озимых сортов зерна тритикале, включенных в реестр сортов, многочисленными исследованиями технологического, биохимического и биологического потенциала зерна тритикале. В связи с этим целью наших исследований стало определение потенциальных мукомольных свойств новых сортов зерна озимого тритикале как сырья для производства тритикалевой муки различного назначения. Объектом исследований потенциальных мукомольных свойств озимого зерна тритикале являются 5 новых сортов - Консул, Капрал, Ацтек, Корнет и Топаз. Определение потенциальных мукомольных свойств новых сортов тритикале проводили на лабораторных мельницах РСА-4 с нарезными и гладкими, микрошероховатыми вальцами. На всех драных системах и вымольной системе использовали рифленые вальцы с расположением рифлей острие по острию, а на размольных системам использовали вальцы с гладкой микрошероховатой поверхностью. Установлено наличие 3-х этапов формирования тритикалевой муки, что достаточно четко видно из графиков кумулятивных кривых. Первый участок – измельчение центральной части эндосперма и включает в себя 3-4 потока. Далее идет второй участок, на котором происходит измельчение эндосперма и периферийной части, включающий в себя 3-4 потока. На третьем, заключительном участке происходит вымол оболочек и включает в себя 3-4 потока. Общий выход тритикалевой муки из сорта Консул составил 73,8 % зольностью 0,80 %, из сорта Капрал составил 77,2 % зольностью 0,94 %, из сорта Ацтек составил 76,4 % зольностью 0,71 %, из сорта Корнет составил 75,6 % зольностью 0,82 %, из сорта Топаз составил 73,2 % зольностью 0,73 %. Наилучшими мукомольными свойствами из представленных образцов тритикале обладает сорт Ацтек выход тритикалевой муки высшего сорта Т-60 из которого составил 59,2% с зольностью 0,59 %.
FEATURES OF THE DYNAMICS OF THE I DEGREE OF SEVERETY BACTERIAL KERATITES IN DIABETIC PATIENTS
Authors: Zavoloka O. V. 
Published: October 2021

Summary. Diabetes mellitus (DM) is a risk factor for severe bacterial keratitis, which often leads to complications.
The aim was to identify the features of the dynamics of the I degree of severity bacterial keratitis in diabetic patients.
Materials and methods. The results of treatment of 15 patients with type 1 DM and bacterial keratitis of the I degree of severity (main group) and 20 patients with bacterial keratitis of the I degree of severity without DM (control group) were analyzed. The severity of bacterial keratitis was determined according to our proposed scheme with a total score of ≤ 14. All patients were treated with instillations of ofloxacin, antiseptics, antioxidants, reparents, artificial tears, mydriatics, systemic anti-inflammatory therapy. In addition to standard, ophthalmic examination methods included bacteriological examination, fluorescein test, OCT of the anterior segment of the eye, non-contact corneal esthesiometry.
Results and discussion. In diabetic patients with bacterial keratitis of the I degree of severity the degree of inflammatory reaction in the anterior chamber of the eye and the average threshold of corneal sensitivity at all airflow temperatures at the first visit exceeded the indicators of controls (p<0.05). The degree of the average corneal sensitivity threshold decrease throughout the observation, the degree of pericorneal injection, the size of the corneal ulcer, the depth of corneal infiltration from the 3rd day of observation, the depth of corneal ulcer and corneal edema from the 7th day exceeded indicators of controls (p<0.05).
Conclusions. Diabetic patients have features of the dynamics of the I degree of severity bacterial keratitis, which lead to prolongation of the disease and worsening of its consequences.
THE FIRST EXPERIENCE OF SURGICAL TREATMENT OF HEMORRHOIDS USING THE WIRELESS DOPPLER OPERATING COMPLEX TRILOGY HAL-RAR UNIT
Authors: Kashtalyan M. , Shapovalov V. , Yenin R. , Makukha A. 
Published: October 2021

Summary. Objective: To improve the results of treatment of patients with stage II-III hemorrhoids using the wireless Doppler surgical complex Trilogy HAL-RAR Unit.
Materials and methods. In the clinic of coloproctology of the Military Medical Clinical Center of the Southern region of Odessa according to the method of disarterization of hemorrhoidal arteries and recto-anal recovery using wireless Doppler surgical complex Wi-3 Trilogy HAL-RAR for the period from January 2019. to June 2020 19 patients were operated on.
Results and discussion. In the postoperative period, moderate pain was observed for three days in 13 patients (68.4 %), only one of them had pain for the first 6 days after surgery. In 6 (31.6 %) patients no complaints of pain in the postoperative area were noted. In all patients, the pain was acquired by taking nonspecific anti-inflammatory drugs without the use of narcotic analgesics. In the postoperative period, patients were examined for 2, 7 and 90 days after surgery. No complications were noted in the postoperative period. In 4 (20 %) patients, due to the presence of enlarged hemorrhoids, the operation was extended by removing the external hemorrhoids and suturing the mucosal defect. All patients noted no reduction in quality of life in the postoperative period.
Conclusions. Surgical treatment of hemorrhoids using Trilogy HAL-RAR technology is a minimally invasive method that reduces the patient’s stay in the hospital in the postoperative period, does not require the use of narcotic analgesics, promotes rapid recovery and may be the surgery of choice for surgical treatment of hemorrhoids II-III.
DIAGNOSIS OF LIVER ENCEPHALOPATHY IN PATIENTS WITH LIVER CIRRHOSIS
Authors: Rusin A. V. , Balazh O. P. 
Published: October 2021

Summary. Aim. Comparison of methods for diagnosis of hepatic encephalopathy in patients with cirrhosis.
Matherials and Methods. We observed 95 patients with LC who were hospitalized from 2018 to 2020 in the Department of Anesthesiology and Intensive Care, Surgical and Gastroenterological Departments of the Transcarpathian Regional Clinical Hospital. Andriy Novak (Uzhhorod). Neurological status, state of mental and cognitive functions in patients with LC were assessed before and after the course of therapy with psychometric testing, as well as electroencephalographic (EEG) study. The severity of LE was determined by West-Haven criteria.
Results. Signs of LE were not diagnosed in 8.4 % of patients with LC. In 13.8 % of patients found a latent form of LE. This was most often observed in the III century. (in 25.2 % of patients), LE II. diagnosed in 22.1 % of patients with LE and Art. — in 17.9 % of examined patients, and in 12.6 % of examined — LE IV. In patients with LC, alpha waves on the EEG are most often registered in the latent form of LE, and with the increase of clinical signs of LE there is a decrease in the frequency of alpha waves, instead of pathological delta and theta waves.
Conclusions. According to the MMSE scale, the highest scores are observed in patients of group I (29.9 ± 3.4). The most pronounced disorders of intelligence were determined in patients with LC of group III from the IV century. LE (15.1 ± 3.3). The level of personal anxiety in patients with LC was higher than normal in patients with LE II-IV centuries. surveyed groups with maximum values in group III (55.5 ± 8.2). At patients with LC the expressed cognitive frustration are observed. Signs of LE were not diagnosed in 8.4 % of patients with LC. In 13.8 % of patients found a latent form of LE. This is most often observed in the III century. (in 25.2 % of patients), LE II. diagnosed in 22.1 % of patients with LE and Art. — in 17.9 % of examined patients, and in 12.6 % of examined — LE IV.
DIAGNOSTICS AND SURGICAL TREATMENT OF POSTTRAUMATIC CICATRICIAL STRICTURES OF THE EXTRAHEPATIC BILE DUCTS
Authors: Shatalov A. D. , Khatsko V. V. , Shatalov S. A. , Kosse D. M. , Polulyakh-Chоrnovol I. F. , Parkhomenko G. V. 
Published: October 2021

Summary. The aim of the work is to improve the results of surgical treatment of iatrogenic injuries of the extrahepatic bile ducts.
Materials and methods. The experience of treating 362 patients with iatrogenic injuries of the extrahepatic bile ducts, obtained mainly in other hospitals over the past 18 years, is presented. In the clinic, these patients are reoperated. Among them were 258 (71.3 %) women and 104 (28,7 %) men aged 20 to 80 years.
Results and discussion.Damage and stricture of the bile duct were noted during laparotomic (299) and laparoscopic (63) cholecystectomy. Damage to the hepatic duct was seen in 235 patients, choledochus — in 127. The main research methods were: percutaneous transhepatic cholangiography, endoscopic retrograde cholangiopancreatography, fistulocholangiography. In the clinic, all 362 patients were operated. In 47 of them were performed restorative operations, and in 315 of them were performed reconstructive ones. At the first stage (until 2004), restorative and reconstructive operations (with transhepatic frame drainage) were used more often. At the 2nd stage (since 2005), the operation of choice was a high hepaticoduodenostomy in 2 modified versions. Over the past 7 years, the number of postoperative complications has been reduced by 8,3 %, mortality from 6,8 to 1,5 %.
Conclusions. The operation of choice in case of complete damage to the bile duct is the formation of a high hepaticojejunoanastomosis according to our modified methods. Reconstructive operations are indicated only in case of partial damage to the bile duct. A multidisciplinary approach to the correction of duct damage is advisable, which should be carried out in specialized surgical hepatological centers. The use of modified methods of reconstructive surgery contributed to a decrease in postoperative complications by 8,3 % and mortality by 5,3 % (95 % CI, p <0.05).