bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studying host genetic background effects on multimorbidity of intestinal cancer development, type 2 diabetes and obesity in response to oral bacterial infection and high‐fat diet using the collaborative cross (CC) lines
Authors: Milhem Asal , Abu Toamih‐Atamni Hanifa J. , Karkar Luna , Houri‐Haddad Yael , Iraqi Fuad A. 
Published: February 2021

AbstractBackgroundMultimorbidity of intestinal cancer (IC), type 2 diabetes (T2D) and obesity is a complex set of diseases, affected by environmental and genetic risk factors. High‐fat diet (HFD) and oral bacterial infection play important roles in the etiology of these diseases through inflammation and various biological mechanisms.MethodsTo study the complexity of this multimorbidity, we used the collaborative cross (CC) mouse genetics reference population. We aimed to study the multimorbidity of IC, T2D, and obesity using CC lines, measuring their responses to HFD and oral bacterial infection. The study used 63 mice of both sexes generated from two CC lines (IL557 and IL711). For 12 weeks, experimental mice were maintained on specific dietary regimes combined with co‐infection with oral bacteria Porphyromonas gingivalis and Fusobacterium nucleatum, while control groups were not infected. Body weight (BW) and results of a intraperitoneal glucose tolerance test (IPGTT) were recorded at the end of 12 weeks, after which length and size of the intestines were assessed for polyp counts.ResultsPolyp counts ranged between 2 and 10 per CC line. The combination of HFD and infection significantly reduced (P < .01) the colon polyp size of IL557 females to 2.5 cm2, compared to the other groups. Comparing BW gain, IL557 males on HFD gained 18 g, while the females gained 10 g under the same conditions and showed the highest area under curve (AUC) values of 40 000‐45 000 (min mg/dL) in the IPGTT.ConclusionThe results show that mice from different genetic backgrounds respond differently to a high fat diet and oral infection in terms of polyp development and glucose tolerance, and this effect is gender related.
Design and numerical investigation of ejector for gas pressurization
Authors: Wang Zhihong , Wang Shicheng , Li Yongzhen , Chen Lin , Zhang Hang 
Published: February 2021

AbstractCompared with the compressor, the ejector is a novel cost‐effective device to pressurize gas. Taking the regeneration natural gas pressurization process in the molecular sieve dehydration system as an example, it is first proposed to replace the compressor with an ejector to accomplish the pressurized recovery of low‐pressure regeneration natural gas. The numerical simulation method has been validated, and its results agree well with published experimental results. The simulation results indicate that the ejector designed with one‐dimensional theory can achieve the low‐pressure gas pressurization. Besides, the influence of operating parameters and structural parameters on the ejector performance is also investigated. As the discharged pressure increases, the entrainment ratio gradually decreases, but the pressure ratio rises linearly. With the increase of the induced flow pressure, the ejector pressurization range reduces. Under different discharged pressure, the entrainment ratio presents three different trends when the primary flow pressure enhances. Also, a larger nozzle exit diameter will cause the shock wave phenomenon, which is not conducive to the ejector performance, so there is an optimal nozzle exit diameter for the ejector. The length of the constant‐area mixing chamber has seldom effect on the pressure ratio. The optimal value of the NXP for entrainment ratio is equal to (0.5–1.0)d2. In conclusion, the research provides a new gas pressurization approach and a much better understanding of the gas flow and mixing process within the ejector.
Epoxidized soybean oil modified using fatty acids as tougheners for thermosetting epoxy resins: Part 2—Effect of curing agent and epoxy molecular weight
Authors: Hu Fengshuo , La Scala John J. , Yadav Santosh Kumar , Throckmorton James , Palmese Giuseppe R. 
Published: February 2021

AbstractA series of bio‐rubber (BR) tougheners for thermosetting epoxy resins was prepared by grafting renewable fatty acids with different chain lengths onto epoxidized soybean oil at varying molar ratios. BR‐toughened samples were prepared by blending BRs with diglycidyl ether of bisphenol A resins, Epon 828 and Epon 1001F, at different weight fractions and stoichiometrically cured using an amine curing agent, 4, 4′‐methylene biscyclohexanamine (PACM). Fracture toughness properties of the unmodified and BR toughened polymer samples—including critical strain energy release rate (GIc), and critical stress intensity factor (KIc)—were measured to investigate the toughening effect of prepared BRs. It was found that the degree of phase separation and toughening were more controllable relative to similar polymers cured using the aromatic curing agent Epikure W, and the use of higher molecular epoxy resins produces a synergistic effect increasing the toughness much more than similar polymers made with lower molecular weight epoxy resins. Average BR domain sizes ranging from 200 to 900 nm were observed, and formulations with GIc, values KIc as high as 1.0 kJ/m2 and 1.4 MPa m1/2 were attained respectively for epoxy systems with Tg greater than 130°C.
The fundamental plane of black hole activity for quiescent sources
Authors: Dong Ai‐Jun , Ge Kang , Liu Xiang , Zhi Qi‐Jun 
Published: February 2021

AbstractIn this work, we construct a sample of black hole X‐ray binaries (BH XRBs), low‐luminosity active galactic nuclei (LLAGNs), and FR Is with wider distribution of Eddington ratios and re‐explore their fundamental plane of BH activities, that is, . We find that the quiescent BH sources follow a similar fundamental plane (ξX ∼ 0.6) with sub‐Eddington BH sources very well, while the strong radio sources (e.g., FR Is) follow a steeper fundamental plane (ξX ∼ 1.30). We also find that the radio–X‐ray correlation of quiescent BH sources are still on the extension of sub‐Eddington BH sources and the strong radio sources follow a steeper correlation (ξX ∼ 1.30). The results are consistent with recent observations in BH XRBs. It is predicted that the X‐ray emissions of both sub‐Eddington BH sources and quiescent BH sources originate from radiatively inefficient accretion mode, while the X‐ray emissions of strong radio sources dominantly originate from the jet.
Power and sample size for random coefficient regression models in randomized experiments with monotone missing data
Authors: Hu Nan , Mackey Howard , Thomas Ronald 
Published: February 2021

AbstractRandom coefficient regression (also known as random effects, mixed effects, growth curve, variance component, multilevel, or hierarchical linear modeling) can be a natural and useful approach for characterizing and testing hypotheses in data that are correlated within experimental units. Existing power and sample size software for such data are based on two variance component models or those using a two‐stage formulation. These approaches may be markedly inaccurate in settings where more variance components (i.e., intercept, rate of change, and residual error) are warranted. We present variance, power, sample size formulae, and software (R Shiny app) for use with random coefficient regression models with possible missing data and variable follow‐up. We illustrate sample size and study design planning using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. We additionally examine the drivers of variability to better inform study design.
Investigating the effects of error‐correction procedures across different skill sets for children with autism
Authors: Lloyd Kirsten , Melanson Isaac J. , Moorehouse Amelia , Klatt Kevin P. 
Published: February 2021

AbstractTeaching skills to children with autism, even when using known effective procedures, sometimes results in learner errors. Several error‐correction procedures have been investigated and found to be generally better than using no error‐correction across studies. The various error‐correction procedures investigated have, however, demonstrated idiosyncratic effects across participants. Although idiosyncratic effects have been consistently found across participants and studies, most of the studies have not investigated whether the results are also idiosyncratic across skills for each participant. Investigating whether results are idiosyncratic across and within participants could be important in determining what error‐correction procedures to use for each learner in applied settings. The purpose of this study was to investigate the effects of four error‐correction procedures across skill sets for children with autism. The results showed idiosyncratic effects across participants (similar to past studies) and also across skill sets within participants. The implications of these results are discussed along with recommendations for future research.
The antecedents of employees' voluntary proenvironmental behavior at work in developing countries: The role of employee affective commitment and organizational support
Authors: Saifulina Nailya , Carballo‐Penela Adolfo , Ruzo‐Sanmartin Emilio 
Published: February 2021

AbstractEmployees can contribute to organizational greening by engaging in green behaviors voluntarily. This work examines the role of four antecedents from an organizational context in the promotion of employees' voluntary pro‐environmental behavior at work: job satisfaction, perceived organizational support, employee affective commitment (EAC), and perceived organizational environmental support (POES), which are directly and indirectly related to voluntary pro‐environmental behavior at work. We also test the moderating effect of POES. We empirically test the proposed hypotheses using SEM with a sample of 331 banking employees from two countries, Ecuador and Kazakhstan. Results demonstrate statistically significant relationships between the proposed antecedents of voluntary pro‐environmental behavior at work, showing the mediating role of EAC, as well as the moderating role of POES.
Anlotinib for previously treated advanced or metastatic esophageal squamous cell carcinoma: A double‐blind randomized phase 2 trial
Authors: Huang Jing , Xiao Juxiang , Fang Wentao , Lu Ping , Fan Qingxia , Shu Yongqian , Feng Jifeng , Zhang Shu , Ba Yi , Zhao Yang , Liu Ying , Bai Chunmei , Bai Yuxian , Tang Yong , Song Yan , He Jie 
Published: February 2021

AbstractBackgroundCurrently, there are no randomized trials on the effect of antiangiogenic therapy in patients with esophageal squamous cell carcinoma (ESCC). The following study investigated the efficacy and safety of anlotinib in patients with advanced ESCC who were previously treated with chemotherapy.MethodsThis randomized, placebo‐controlled, double‐blind phase 2 trial (NCT02649361) was conducted in 13 Chinese hospitals. Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC who were previously treated with chemotherapy, and were randomly assigned (2:1) to receive oral anlotinib 12 mg or placebo on days 1–14 (repeated every 21 days). The primary endpoint was progression‐free survival (PFS).ResultsOne hundred and sixty‐five patients were randomly assigned to the anlotinib (n = 110) or the placebo (n = 55) arm. Median PFS was 3.02 months (95% CI 2.63–3.65) in the anlotinib group and 1.41 months (95% CI 1.38–1.41) in the placebo group (hazard ratio 0.46 [95% CI 0.32–0.66]; p < 0.001). The most common treatment‐related adverse events of grade 3 or 4 were hypertension (17 [16%] patients), decreased appetite (6 [6%] patients), and hyponatremia (4 [4%] patients) in the anlotinib group and decreased appetite (2 [4%] patients) in the placebo group. Three (3%) deaths in the anlotinib group were considered as drug related, while there were no treatment‐related deaths in the placebo group.ConclusionsThe use of anlotinib in previously treated, recurrent, or metastatic ESCC patients significantly improved PFS compared with placebo. Our findings suggest that antiangiogenesis might be an important therapeutic target in advanced ESCC.Clinical Trials RegistrationStudy of Anlotinib in Patients With Esophageal Squamous Cell Carcinoma (ALTER1102), NCT02649361.
An interventional approach to left ventricular assist device outflow graft obstruction
Authors: Gertz Zachary M. , Trankle Cory R. , Grizzard John D. , Quader Mohammed A. , Medalion Benjamin , Parris Kendall E. , Shah Keyur B. 
Published: February 2021

AbstractBackgroundLVADs provide life‐sustaining treatment for patients with heart failure, but their complexity allows for complications. One complication, LVAD outflow graft obstruction, may be misdiagnosed as intraluminal thrombus, when more often it is extraluminal compression from biodebris accumulation. It can often be treated endovascularly with stenting. This case series describes diagnostic and procedural techniques for the treatment of left ventricular assist device (LVAD) outflow graft obstruction.MethodsWe present four patients with LVADs who developed LVAD outflow graft obstruction within the bend relief‐covered segment. All were initially diagnosed with computed tomographic angiography (CTA). All underwent invasive evaluation with intravascular ultrasound (IVUS), then were treated with stenting. After misdiagnosing a twist, we developed the technique of balloon “graftoplasty” to ensure suitability for stent delivery in subsequent cases.ResultsAll patients presented with low‐flow alarms and symptoms of low output, and were diagnosed with outflow graft obstruction by CTA. In all four, IVUS confirmed an extraluminal etiology. Patient 1 was treated with stenting and had a good outcome. Patient 2's obstruction was from twisting, rather than biodebris accumulation, and had sub‐optimal stent expansion and ultimately required surgery. Balloon “graftoplasty” was used in subsequent cases to ensure subsequent stent expansion. Patients 3 and 4 were successfully stented. All improved after treatment.ConclusionsIn patients with LVAD outflow graft obstruction, IVUS can distinguish intraluminal thrombus from extraluminal compression. Balloon “graftoplasty” can ensure that the outflow graft will respond to stenting. Many cases of LVAD outflow graft obstruction should be amenable to endovascular treatment.
Entecavir administration to pregnant Japanese woman with chronic hepatitis B and hepatocellular carcinoma: A case report
Authors: Kakiuchi Toshihiko , Takahashi Hirokazu , Iwane Shinji , Koji Azusa , Matsuo Muneaki 
Published: February 2021

AbstractWomen taking entecavir hydrate (ETV) may not need to consider abortion in the event of an unexpected pregnancy. If a woman with renal dysfunction and taking ETV for chronic hepatitis B becomes pregnant, continuous use of ETV may also be tolerated.
Three‐dimensional mapping discovered arrhythmic substrate missed in the initial diagnosis of idiopathic ventricular fibrillation
Authors: Harano Yoshihiro , Masuda Keita , Inoue Shunsuke , Iioka Yuto , Kowase Shinya , Osada Jun , Yumoto Kazuhiko 
Published: February 2021

AbstractDuring an initial diagnosis of IVF, an arrhythmic substrate may be missed for several reasons such as lack of information; thus, a careful follow‐up is important. A three‐dimensional mapping may identify a possible missed arrhythmic substrate in IVF.
Labor induction in pregnancy complicated by myelodysplastic syndrome: A case report
Authors: Peng Changsheng , Cui Tao , Yao Qiang 
Published: February 2021

AbstractPregnancy may aggravate myelodysplastic syndrome. Cross‐matched platelets can be used in cases of refractory thrombocytopenia. Vaginal delivery can be attempted if the platelet count is at least 20 × 109/L.
Connectivity‐informed adaptive regularization for generalized outcomes
Authors: Brzyski Damian , Karas Marta , M Ances Beau , Dzemidzic Mario , Goñi Joaquín , W Randolph Timothy , Harezlak Jaroslaw 
Published: February 2021

AbstractOne of the challenging problems in neuroimaging is the principled incorporation of information from different imaging modalities. Data from each modality are frequently analyzed separately using, for instance, dimensionality reduction techniques, which result in a loss of mutual information. We propose a novel regularization method, generalized ridgified Partially Empirical Eigenvectors for Regression (griPEER), to estimate associations between the brain structure features and a scalar outcome within the generalized linear regression framework. griPEER improves the regression coefficient estimation by providing a principled approach to use external information from the structural brain connectivity. Specifically, we incorporate a penalty term, derived from the structural connectivity Laplacian matrix, in the penalized generalized linear regression. In this work, we address both theoretical and computational issues and demonstrate the robustness of our method despite incomplete information about the structural brain connectivity. In addition, we also provide a significance testing procedure for performing inference on the estimated coefficients. Finally, griPEER is evaluated both in extensive simulation studies and using clinical data to classify HIV+ and HIV−individuals.
Is coronary multivessel disease in acute myocardial infarction patients still associated with worse clinical outcomes at 1‐year?
Authors: Puymirat Etienne , Nakache Ariel , Saint Etienne Christophe , Marcollet Pierre , Fichaux Olivier , Decomis Marie‐Pascale , Chassaing Stephan , Commeau Philippe , Danchin Nicolas , Cayla Guillaume , Montalescot Gilles , Benamer Hakim , Koning Rene , Motreff Pascal , Rangé Grégoire 
Published: February 2021

AbstractBackgroundST‐elevation myocardial infarction (STEMI) patients with multivessel disease (MVD) are associated with a worse prognosis. However, few comparisons are available according to coronary status in the era of modern reperfusion and optimized secondary prevention.HypothesisWe hypothesized that the difference in prognosis according to number of vessel disease in STEMI patients has reduced.MethodsAll consecutive STEMI patients undergoing primary percutaneous coronary intervention (PCI) within 24 h of symptoms onset between January 1, 2014 and June 30, 2016 enrolled in the CRAC (Club Régional des Angioplasticiens de la région Centre) France PCI registry were analyzed. Baseline characteristics, management, and outcomes at 1‐year were analyzed according to coronary status (one‐, two‐, and three‐VD).ResultsA total of 1886 patients (mean age 62.2 ± 14.0 year; 74% of male) were included. Patients with MVD (two or three‐VD) represented 53.7%. They were older with higher cardiovascular risk factor profile. At 1 year, the rate of major adverse cardiovascular events (MACE, defined as all‐cause death, stroke or re‐MI) was 10%, 12%, and 12% in one‐, two, and three‐VD respectively (p = .28). In multivariable adjusted Cox proportional hazard regression model, two‐ and three‐VD were not associated with higher rate of MACE compared to patients with single VD (HR, 1.09; 95%CI 0.76–1.56 for two‐VD; HR, 0.74; 95%CI 0.48–1.14 for three‐VD).ConclusionsMVD still represents an important proportion of STEMI patients but their prognoses were not associated with worse clinical outcomes at 1‐year compared with one‐VD patients in a modern reperfusion area and secondary medication prevention.
Plasmid DNA‐Based Bioluminescence‐Activated System for Photodynamic Therapy in Cancer Treatment
Authors: Fan Di , Wang Ting , Hu Jinhui , Zhou Lin , Zhou Jiahong , Wei Shaohua 
Published: February 2021

AbstractThe low depth of tissue penetration by therapeutic light sources severely restricts photodynamic therapy (PDT) in treating deep‐seated tumors. Using a luciferase/d‐luciferin bioluminescence system to artificially create internal light sources in cells instead of external light sources is an effective means of solving the above problems. However, high‐efficiency bioluminescence requires a higher concentration of luciferase in the cell, which poses a considerable challenge to the existing system of enzyme loading, delivery, activity and retention of drugs, and dramatically increases the cost of treatment. We loaded the substrate D‐luciferin, and the photosensitizer hypericin into a polyethyleneimine (PEI)‐modified nano‐calcium phosphate (CaP) to solve this problem. Subsequently, the plasmid DNA containing the luciferase gene was loaded onto it using the high‐density positive charge characteristic of PEI from the nanodrug (denoted DHDC). After the DHDC enters the tumor cell, it collapses and releases the plasmid DNA, which uses the intracellular protein synthesis system to continuously and massively express luciferase. Using endogenous ATP, Mg2+, and O2 in cells, luciferase oxidizes d‐luciferin and produces luminescence. The luminescence triggers hypericin excitation to generate ROS and kill cancer cells. This study provides a new strategy for the application of bioluminescence in PDT treatment.
The Acid/Base Characterization of Molecules with Epigenetic Activity
Authors: Santibáñez‐Morán Marisa G. , Medina‐Franco José L. 
Published: February 2021

AbstractThe acidic and basic functional groups in a molecule strongly influence its physicochemical properties, affinity for a macromolecule, pharmacokinetics, and toxicity. For instance, basicity has been correlated with molecular promiscuity, hERG blockade, and phospholipidosis. Nonetheless, no systematic characterization of the acid/base profile of epigenomic databases has been reported. This study describes an analysis of the acidic ionization constant distribution of a library of 7820 compounds with reported activity against epigenetic targets. Furthermore, the epigenomics database's acid/base profile was compared to the reference libraries of food chemicals, natural products, and approved drugs. It was found that the acid/base profile of histone lysine demethylase ligands is more similar to previously approved drugs, and histone acetyltransferase ligands have acidic and basic functional groups largely found in food chemicals and natural products; this support the potential of these libraries for finding new epigenetic inhibitors.
Improved hybrid cuckoo black widow optimization with interval type 2 fuzzy logic system for energy‐efficient clustering protocol
Authors: Sheriba S.T. , Hevin Rajesh D. 
Published: February 2021

SummaryRecently, due to its excellent performance with the limited resources the wireless sensor network (WSN) is a challenging research area. The WSN consists of the number of nodes and power resources with limited energy parameters, but it comprises few difficulties. The energy‐efficient distributed clustering (HEED) is an efficient routing protocol in recent years. This paper proposes IHCBW with interval type 2 fuzzy logic system‐based HEED (IIT2FLS‐HEED) method. We used the combination of cuckoo search (CS) and improved black widow optimization (IBWO) algorithms (IHCBW) for the selection of optimal residual energy selection. The optimal cluster heads (CHs) are chosen with the help of the interval type 2 fuzzy logic system (IT2FLS). Experimentally, the NS2 software handles the entire proposed work and its performance is evaluated with different kinds of performance evaluation. Moreover, 20 benchmark functions are used to validate the performance of the IHCBW algorithm. Finally, the proposed IIT2FLS‐HEED demonstrates better performance results in terms of homogenous, second, and third stage heterogeneous WSN.