bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for rabid animal bites: a study in domestic ruminants in Mymensingh district, Bangladesh
Authors: Noman Z. , Anika T. T. , Haque Z. F. , Rahman A. K. M. A. , Ward M. P. , Martínez-López B. 
Published: March 2021

Abstract
Rabies is endemic in Bangladesh. To identify risk factors, a case-control study was conducted based on hospital-reported rabid animal bite (RAB) cases in domestic ruminants, 2009 − 2018. RAB cases (n = 449) and three controls per case were selected. Dogs (87.8%) and jackals (12.2%) were most often identified as biting animals. In the final multivariable model, the risk of being a RAB case was significantly higher in cattle aged >0.5–2 years (odds ratio (OR) 2.89; 95% confidence interval (CI): 1.56–5.37), >2–5 years (OR 3.63; 95% CI: 1.97–6.67) and >5 years (OR 6.42; 95% CI: 3.39–12.17) compared to those aged <0.5 years. Crossbred cattle were at higher risk of being a RAB case (OR 5.48; 95% CI: 3.56–8.42) than indigenous. Similarly, female cattle were more likely to be a RAB case (OR 1.26; 95% CI: 1.15–2.29) than males. Cattle in rural areas (OR 39.48; 95% CI: 6.14–254.00) were at a much higher risk of being RAB cases than those in urban areas. Female, crossbred and older cattle, especially in rural areas should either be managed indoors during the dog breeding season (September and October) or vaccinated. A national rabies elimination program should prioritise rural dogs for mass vaccination. Jackals should also be immunised using oral bait vaccines. Prevention of rabies in rural dogs and jackals would also reduce rabies incidence in humans.
Seeing the forest and the trees: Disentangling autism phenotypes in the age of DSM-5
Authors: Volkmar Fred R. , Woodbury-Smith Marc , Macari Suzanne L. , Øien Roald A. 
Published: March 2021

AbstractThis paper, written in honor of Professor Ed Zigler, focuses on some of the themes in developmental disabilities research that were so central to his work. It has now been nearly 80 years since Leo Kanner first identified the prototypic form – early infantile autism – of what is now autism spectrum disorder. In this article we summarize the development of the concept and the important accumulation of knowledge over time that has now led us to the recognition of a broader autism phenotype just as, at the same time, the current official diagnostic system in the USA has narrowed the concept. We also address current controversies regarding autism as the diagnosis is impacted by age and developmental factors, gender, and cultural issues. In parallel to the work on intellectual deficiency and development pioneered by Zigler and his colleagues, we summarize some of the challenges for the years ahead.
Long-acting injectable antipsychotics: what, when, and how
Authors: Citrome Leslie 
Published: March 2021

AbstractCurrent guidelines for the treatment of patients with schizophrenia advocate that patients receive treatment with a long-acting injectable (LAI) antipsychotic medication if they prefer such treatment or if they have a history of poor or uncertain adherence. Available LAI formulations in the United States include first-generation antipsychotics (fluphenazine decanoate and haloperidol decanoate), risperidone/paliperidone containing products (risperidone microspheres, paliperidone palmitate, and risperidone subcutaneous), aripiprazole containing products (aripiprazole monohydrate and aripiprazole lauroxil), and olanzapine pamoate. LAI antipsychotics can address the guesswork about adherence status and patients may prefer them if they are offered this as a choice, including individuals early in their disease course. Additional approved indications in the United States for LAI antipsychotics include bipolar I disorder maintenance treatment for risperidone microspheres and aripiprazole monohydrate, and schizoaffective disorder for paliperidone palmitate once monthly. Differences and similarities among the different products are discussed, including guidance regarding optimal treatment selection. Tips are provided to enhance effective patient communication to maximize the likelihood of acceptance of this treatment modality.
Diagnosing and treating major depressive episodes that lie along the mood disorders spectrum: focus on depression with mixed features
Authors: McElroy Susan L. , Guerdjikova Anna I. , Romo-Nava Francisco 
Published: March 2021

AbstractGrowing evidence indicates that historical descriptions of mixed depression—broadly defined as major depressive episodes with subthreshold manic or hypomanic (hypo/manic) symptoms—are incredibly clinically relevant in this day-and-age. However, the first operational definition of mixed depression did not occur in the modern nomenclature until 2013 with publication of Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5), and there has not been enough time to evaluate these criteria empirically. Thus, the most valid operational definition of a mixed depressive episode is still unknown, widely accepted treatment guidelines are not available, and no treatment has regulatory approval for mixed depression—whether associated with bipolar I disorder, bipolar II disorder, or major depressive disorder. This is despite seven drugs having regulatory indications for mixed episodes, defined as the co-occurrence of syndromal depression and syndromal mania, and now recognized as mania with mixed features by DSM-5. Indeed, we found only two randomized, placebo-controlled trials in patients with protocol defined mixed depression, one with ziprasidone and one with lurasidone. Both studies were positive, suggesting treatment with second-generation antipsychotics may be helpful for mixed depressive episodes associated with bipolar II or unipolar disorder. We found no randomized control trial of antidepressant monotherapy in mixed depression and many clinical reports that such treatment may worsen mixed depression Randomized, placebo-controlled trials of antidepressants, antipsychotics, and mood stabilizers—alone and in combination—in individuals with carefully defined mixed depression are needed before firm treatment guidelines can be produced.
Colonialism and Compromise: The Shanghai Municipal Police and the Arrest of Communists, 1927–37
Authors: LAW PETER KWOK-FAI 
Published: March 2021

AbstractThe Shanghai Municipal Council (SMC), which was mainly controlled by British residents in the treaty port of Shanghai, and protected by the British Foreign Office, came under serious challenge from the Guomindang (GMD) (the rising Nationalist Party of China) from 1927 onwards. The Shanghai Municipal Police (SMP)—an imperial police force with powers to arrest, prosecute and detain—was forced to collaborate with the GMD, and practice unlawful arrest, extradition and re-indoctrination of Communist suspects and convicts. This resulted in the erosion of state powers and the management of prisons. This article argues that the dismantling of British colonialism began to take place in Shanghai during the inter-war period at the expense of some English legal conventions, as demonstrated by SMP violations of existing legal practices and humanitarian commitments. Second, it also suggests that English judicial conventions had an unintended impact on some Chinese civilians, who were keen to safeguard their rights during their detention and trial in and beyond the Shanghai Legation. This article, therefore, offers a new periodisation of British decolonisation and a re-examination of colonial legacy in East Asia.
Regulative Principles and Kinds of the Unconditioned
Authors: Breitenbach Angela 
Published: March 2021

AbstractIn his Kant on Laws, Eric Watkins presents an account of reason on which the principles of specification and continuity are regulative instructions to search for different kinds of the unconditioned. I suggest that we correct Watkins’ account in two ways. First, we need to complete Watkins’ claim to the plurality of the unconditioned: reason aims for three kinds of the unconditioned, associated with the lowest, next and highest concepts. Second, we need to look beyond reason’s search for the unconditioned in order to properly understand the nature of the aim of reason. I argue that we construe reason’s aim as the systematic unity of cognition considered as a whole or, in Kant’s teleological terms, as the realization of an ‘idea’, or a ‘purposive unity’.
Biodiversity conservation as infectious disease prevention: why a social-ecological perspective is essential
Authors: Schneider Florian D. , Matias Denise Margaret , Burkhart Stefanie , Drees Lukas , Fickel Thomas , Hummel Diana , Liehr Stefan , Schramm Engelbert , Mehring Marion 
Published: March 2021

Non-technical summaryInvesting in stricter biodiversity conservation and wildlife protection to reduce the number of emerging diseases and, consequently, the risk of pandemics such as coronavirus disease-19 (COVID-19), must integrate a social-ecological perspective. Biodiversity conservation, in order to be effective as disease prevention, requires consideration of people's needs, knowledge and institutions within their locally specific contexts. To meet this goal, future biodiversity research and conservation policy should apply six social-ecological principles for shaping future practices of co-existence of societies and nature.Technical summaryThe COVID-19 pandemic, presumably originating in a spillover event from natural wildlife reservoirs into the human population, sets a new benchmark for the indirect cost of biodiversity exploitation. To reverse the trend of increasing pandemic risk, biodiversity conservation and wildlife protection must be strengthened globally. In this paper, we argue that such preventive measures explicitly need to employ a social-ecological approach. In particular, attention must be paid to the societal relations to nature to avoid falling for simplistic solutions that neglect regional and local particularities of both, biodiversity and local communities. We emphasize the importance of avoiding a Western-biased view and acknowledging the factors and causations of infectious disease emergence in industrialized countries. To reduce the emergence of zoonotic and vector-borne diseases in their specific contexts, we propose applying a social-ecological systems approach by integrating plural local knowledge and values, established practices, formal and informal institutions, as well as technology. We further introduce six social-ecological principles for shaping transformations in the Anthropocene to maintain and build more resilient and sustainable communities. By operationalizing these inter- and transdisciplinary principles, biodiversity conservation can be effectively implemented as infectious disease prevention.Social media summaryA social-ecological approach to biodiversity conservation can pave the way for an effective and socially just reduction of future pandemic risks.
Prediction of Gas Hydrate Formation at Blake Ridge Using Machine Learning and Probabilistic Reservoir Simulation
Authors: Eymold William K. , Frederick Jennifer M. , Nole Michael , Phrampus Benjamin J. , Wood Warren T. 
Published: March 2021

AbstractMethane hydrates are solid structures containing methane inside of a water lattice that form under low temperature and relatively high pressure. Appropriate hydrate‐forming conditions exist along continental shelves or are associated with permafrost. Hydrates have garnered scientific interest via their potential as a source of natural gas and their role in the global carbon cycle. While methane hydrates have been collected in multiple diverse geographic settings, their quantities and distribution in sediments remain poorly constrained due to sparse relevant data. Using statistical and machine learning approaches, we have developed a workflow to probabilistically predict methane hydrate occurrence from local microbial methane sourcing. This approach utilizes machine‐learned global maps produced by the Global Predictive Seabed Model (GPSM) as inputs for the statistical sampling software, Dakota, and multiphase reservoir simulation software, PFLOTRAN. Dakota performs Latin hypercube sampling of the GPSM‐predicted values and uncertainties to generate unique sets of input parameters for 1‐D PFLOTRAN simulations of gas hydrate and free gas formation resulting from methanogenesis to steady state. We ran 100 1‐D simulations spanning a kilometer in depth at 5,297 locations near Blake Ridge. Masses of hydrate and free gas formed at each location were determined by integrating the predicted saturation profiles. Elevated hydrate formation is predicted to occur at depths >500 meters below sea level at this location, and is strongly associated with high seafloor total organic carbon values. We produce representative maps of expected hydrate occurrence for the study area based on multiple realizations that can be validated against geophysical observations.
Over‐Darkening of Pulsating Aurora
Authors: Hosokawa K. , Miyoshi Y. , Oyama S.‐I. , Ogawa Y. , Kurita S. , Kasahara Y. , Kasaba Y. , Yagitani S. , Matsuda S. , Ozaki M. , Tsuchiya F. , Kumamoto A. , Takashima T. , Shinohara I. , Fujii R. 
Published: March 2021

AbstractRecent analyses of high‐time resolution ground‐based optical observations of pulsating aurora (PsA) have reported that the brightness of PsA sometimes decreases below the diffuse background level immediately after the ON phase of the main pulsation finishes. To date, however, the generation mechanism of such an “over‐darkening PsA” is still unclarified. In this study, we investigated the characteristics of the over‐darkening PsA by using simultaneous observations of PsA with an electron multiplying charge coupled device all‐sky camera in Sodankylä, Finland and the Arase satellite. During one of the conjunction events in Scandinavia on March 29, 2017, almost all the PsA pulses showed clear over‐darkening characteristics. By analyzing the 2D all‐sky images at the times of over‐darkening we discovered that over‐darkening areas appeared in the trailing edge of PsA patches and moved in tandem with the poleward propagating patches. It was also found that similar over‐decreasing characteristics were not seen in the chorus data from the wave instruments onboard Arase located at the magnetospheric counterpart of PsA. These results indicate that the over‐darkening PsA is not caused by a temporal variation of chorus at a fixed point, but is produced by a propagation of over‐darkening area with PsA patches. That is, the over‐darkening PsA is a result of compounding effects of spatial structure and recurrent propagation of PsA. The mechanism creating the dark area is still unknown, but the existence of over‐darkening PsA suggests that the temporal variation of PsA is not always a perfect copy of the modulation of lower‐band chorus waves in the magnetosphere.
The Origin of Felsic Intrusions Within the Mantle Section of the Samail Ophiolite: Geochemical Evidence for Three Distinct Mixing and Fractionation Trends
Authors: Rioux Matthew , Benoit Mathieu , Amri Isma , Ceuleneer Georges , Garber Joshua M. , Searle Michael , Leal Kayla 
Published: March 2021

AbstractAn isotopically diverse suite of felsic dikes, sills, and plugs (εNd(t) = −7.8 to +7.8) intrude the uppermost mantle and lower crust in the Samail ophiolite in Oman and the United Arab Emirates (UAE). These features have been interpreted to represent amphibolite and metasediment melts from an underthrust sheet of oceanic lithosphere. As such, the intrusions provide a record of melting of oceanic crust and sediment at depth, with implications for mass transfer from the down‐going plate in young, hot subduction settings. Several studies have used geochemical data to constrain the magmatic sources of the dikes; here we build on this previous work using integrated whole rock major element, trace element and Nd isotopic data from a more geographically extensive suite of dikes. New and existing data suggest the felsic intrusions preserved within mantle peridotites in the Oman portion of the ophiolite were generated by three distinct mixing and fractionation trends: (1) three‐component mixing between sediment melt, amphibolite melt and a mantle component; (2) two component mixing between amphibolite and sediment melts, with little mantle contribution; and (3) fractional crystallization of depleted, mantle derived magmas, likely related to the ophiolite V2 volcanic series. Combined geochemical and pseudosection modeling suggest that amphibolite melting occurred at P ≤ 1.4 GPa (∼40–45 km) and T ≥ 700–750°C. Felsic intrusions in the mantle section in the UAE, including garnet‐andalusite‐cordierite leucogranites, follow similar mixing trends, but crystallized ∼0.9–4.0 Ma after the Oman intrusions.
Evidence for Fluids at the Hypocenter of the 2017 Ms 7.0 Jiuzhaigou Earthquake Revealed by Local Earthquake Tomography
Authors: Chen Shuze , Zhao Junmeng , Xu Qiang , Liu Hongbing , Ju Changhui 
Published: March 2021

AbstractThe seismogenic structure of the 2017 Ms 7.0 Jiuzhaigou earthquake is still under debate. To address this issue, we use arrival times of P‐ and S‐ waves from 1766 local earthquakes recorded by our deployed 18 temporary seismic stations to perform the local earthquake tomography and present the 3‐D distributions of the P‐ wave and S‐ wave velocities (Vp and Vs), Vp/Vs ratio and the locations of the relocated aftershocks in the source region of the 2017 Jiuzhaigou earthquake. The aftershocks occurred at depths of 2–10 km, and can be divided into a NNW‐SSE trending northern segment and a NW‐SE trending southern segment relative to hypocenter of the main shock. Combined with previous observations, it is proposed that the Jiuzhaigou earthquake occurred on an unmapped fault which is a branch of the easternmost segment of the eastern Kunlun fault zone. The source region of the Jiuzhaigou earthquake is characterized by high Vp and low Vs anomalies as well as high Vp/Vs ratios, suggesting the presence of fluids in the fractured rocks. These fluids may have contributed to the occurrence of the Jiuzhaigou earthquake by reducing the effective normal stress and thus causing the brittle failure of rocks.
ENSO Variability During the Medieval Climate Anomaly as Recorded by Porites Corals From the Northern South China Sea
Authors: Jiang Leilei , Yu Kefu , Tao Shichen , Wang Shaopeng , Han Tao , Jiang Wei 
Published: March 2021

AbstractThe El Niño–Southern Oscillation (ENSO) dominates interannual climate variability worldwide and has important environmental and socio‐economic consequences. However, determining the evolution of ENSO variability and its long‐term response to climate forcing remains an ongoing challenge owing to the limited instrumental records. In this study, we quantified ENSO variability via an empirically calibrated threshold and sliding variance windows using monthly sea‐surface temperature (SST) anomalies based on Porites coral Sr/Ca records from the Xisha Islands in the northern South China Sea. Instrumental SST anomalies from the Xisha Islands correctly captured increasing ENSO variability in the twentieth century, with ENSO detection skills similar to those for Niño3.4 regions. Coral Sr/Ca‐SST anomalies can also serve as sensitive and robust proxies for ENSO variability. Sub‐fossil coral Sr/Ca‐SST anomalies indicated intensified ENSO variability at the end of the Medieval Climate Anomaly (MCA) from 1149 to 1205 ± 4.9 (2σ) Common Era (CE). Combining our records with other ENSO‐sensitive proxy reconstructions from the tropical Pacific, we observed fluctuating ENSO variability during the MCA and intensified ENSO variability for the late MCA. Considering the fewer and low intensity fluctuations associated with external climate forcing and the absence of a coherent temporal correspondence of ENSO activity with solar irradiance and volcanic eruption during the MCA, we hypothesized that the internal dynamics of the climate system play a prominent role in modulating ENSO variability and its evolution, which is supported by unforced climate model simulations and coral reconstructions across the tropical Pacific.
Plasmonic semiconductor nanogroove array enhanced broad spectral band millimetre and terahertz wave detection
Authors: Tong Jinchao , Suo Fei , Zhang Tianning , Huang Zhiming , Chu Junhao , Zhang Dao Hua 
Published: March 2021

AbstractHigh-performance uncooled millimetre and terahertz wave detectors are required as a building block for a wide range of applications. The state-of-the-art technologies, however, are plagued by low sensitivity, narrow spectral bandwidth, and complicated architecture. Here, we report semiconductor surface plasmon enhanced high-performance broadband millimetre and terahertz wave detectors which are based on nanogroove InSb array epitaxially grown on GaAs substrate for room temperature operation. By making a nanogroove array in the grown InSb layer, strong millimetre and terahertz wave surface plasmon polaritons can be generated at the InSb–air interfaces, which results in significant improvement in detecting performance. A noise equivalent power (NEP) of 2.2 × 10−14 W Hz−1/2 or a detectivity (D*) of 2.7 × 1012 cm Hz1/2 W−1 at 1.75 mm (0.171 THz) is achieved at room temperature. By lowering the temperature to the thermoelectric cooling available 200 K, the corresponding NEP and D* of the nanogroove device can be improved to 3.8 × 10−15 W Hz−1/2 and 1.6 × 1013 cm Hz1/2 W−1, respectively. In addition, such a single device can perform broad spectral band detection from 0.9 mm (0.330 THz) to 9.4 mm (0.032 THz). Fast responses of 3.5 µs and 780 ns are achieved at room temperature and 200 K, respectively. Such high-performance millimetre and terahertz wave photodetectors are useful for wide applications such as high capacity communications, walk-through security, biological diagnosis, spectroscopy, and remote sensing. In addition, the integration of plasmonic semiconductor nanostructures paves a way for realizing high performance and multifunctional long-wavelength optoelectrical devices.
Microbial hitchhiking: how Streptomyces spores are transported by motile soil bacteria
Authors: Muok Alise R , Claessen Dennis , Briegel Ariane 
Published: March 2021

Abstract
Streptomycetes are sessile bacteria that produce metabolites that impact the behavior of microbial communities. Emerging studies have demonstrated that Streptomyces spores are distributed through various mechanisms, but it remains unclear how spores are transported to their preferred microenvironments, such as plant roots. Here, we show that Streptomyces spores are capable of utilizing the motility machinery of other soil bacteria. Motility assays and microscopy studies reveal that Streptomyces spores are transported to plant tissues by interacting directly with the flagella of both gram-positive and gram-negative bacteria. Genetics experiments demonstrate that this form of motility is facilitated by structural proteins on the spore coat. These results demonstrate that nonmotile bacteria are capable of utilizing the motility machinery of other microbes to complete necessary stages of their lifecycle.