bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overview of mouthfeel from the perspective of sensory scientists in industry
Authors: Ditschun Tanya L. , Riddell Erin , Qin Wei , Graves Karen , Jegede Oyelayo , Sharafbafi Negin , Pendergast Teresa , Chidichimo Darci , Wilson Suzanne F. 
Published: February 2025

AbstractMouthfeel is vital in consumer acceptance of foods and beverages. Despite the critical role mouthfeel plays in product development, the concept is often poorly understood and subject to various interpretations. Within this review, five topics of interest are discussed to provide a better understanding of the mouthfeel attribute—the definition, the perception, the importance, the influencing factors, and the methods of measurement of mouthfeel. Mouthfeel encompasses multiple attributes. Although mouthfeel attributes perceived through physical and chemical perceptions, such as cooling and heating, are understood as mouthfeel, attributes perceived through mechanoreceptors, such as creaminess and thickness, are more challenging due to varying opinions on texture and mouthfeel. Other factors, like food composition and temperature, are also vital in understanding the overall effect of mouthfeel in food and beverages. Including all perceived attributes and factors is important for consumer acceptance of products and for developing consistent evaluation of products. Other topics to consider include the dynamic aspects of oral processing and cultural backgrounds as these topics create additional intricacies in defining and understanding mouthfeel perception. Despite the lack of instrumental methodology available to measure mouthfeel attributes, trained panelists can be used to predict facets of mouthfeel in the eating experience. When designing sensory testing for trained panelists, experimental conditions and a product‐specific lexicon are important factors to consider. Overall, understanding of the mouthfeel attributes and their role in consumer preference for different types of food and beverages continues to evolve.
Iron‐Deficiency Anemia Elevates Risk of Diabetic Kidney Disease in Type 2 Diabetes Mellitus
Authors: Huang Bin , Wen Wenjie , Ye Shandong 
Published: February 2025

ABSTRACTObjectiveThis study aims to explore the link between iron deficiency anemia (IDA) and diabetic kidney disease (DKD) and assess the safety of iron supplementation. It also investigates key mechanisms and molecules involved in iron deficiency's role in disease development.MethodsA retrospective analysis was conducted on 1,398 T2DM patients using propensity score matching to identify risk factors for DKD. Mendelian randomization (MR) was used to explore causal relationships between IDA, iron supplementation, liver iron content, and DKD. The GSE27999 dataset was analyzed to examine how an iron‐deficient diet affects kidney‐related gene expression. Key pathways and molecules were identified through GSEA, GO/KEGG, and PPI analysis.ResultsRetrospective data showed a correlation between hemoglobin levels and DKD risk. Logistic regression confirmed that IDA increased DKD risk independently of other factors. MR revealed a causal link between IDA and DKD, with no significant effect from iron supplementation. GSE27999 analysis identified 580 differentially expressed genes, enriched in pathways like cytokine signaling, oxidative biology, and small molecule transport. PPI analysis highlighted 10 key hub genes, including Cyp2d26 and Fgf4.ConclusionIDA increases susceptibility to DKD, possibly through oxidative stress and altered small molecule transport. However, iron supplementation does not appear to increase the risk of DKD.
Exploring the Clinical Value of Perioperative ctDNA‐Based Detection of Molecular Residual Disease in Patients With Esophageal Squamous Cell Carcinoma
Authors: Li Jimin , Wu Congcong , Song Yongming , Fan Yuhui , Li Chao , Li Haibo , Zhang Shuangping 
Published: February 2025

ABSTRACTObjectiveTo explore the clinical value of molecular residual disease detection based on circulating tumor DNA (ctDNA‐MRD) in the perioperative period of esophageal squamous cell carcinoma (ESCC) and to analyze the tumor escape mechanisms in MRD‐positive cases.MethodsA total of 35 ESCC patients were prospectively enrolled. Preoperative and postoperative (1 month after surgery) blood and surgical tissue samples were analyzed. ctDNA variants were tracked in plasma to assess ctDNA‐MRD, and whole‐transcriptome sequencing was performed on MRD‐positive and MRD‐negative tissue samples.ResultsPreoperative blood ctDNA was positive in 54.3% of patients, with a 31.6% positive predictive value for recurrence. One month postsurgery, the positive rate of ctDNA was 17.1%, with an 83.3% predictive value for recurrence. Both preoperative and postoperative ctDNA positivity were significant prognostic indicators (HR = 2.78, p < 0.05; HR = 4.42, p < 0.001). Multivariate analysis confirmed ctDNA as an independent prognostic factor (HR = 303.75, p < 0.001). Transcriptomic analysis revealed increased macrophage (W = 15 848; p < 0.01) and follicular helper T (Tfh) cell (W = 10 935; p < 0.01) levels in MRD‐positive patients, suggesting a potential link to immune escape in tumors.ConclusionsPlasma ctDNA measured 1 month postoperatively in ESCC patients can effectively detect MRD, and ctDNA‐MRD serves as an independent risk factor for postoperative recurrence. The mechanism underlying MRD positivity may involve the polarization of Tfh cells and macrophages, aiding tumor cells in immune escape through the bloodstream.
Sequential Hypothermic and Normothermic Machine Perfusion of Extended Criteria Donors in Liver Transplantation: A Single‐Center Preliminary Experience
Authors: Magistri Paolo , Zamboni Silvia , Catellani Barbara , Guidetti Cristiano , Esposito Giuseppe , Caracciolo Daniela , Odorizzi Roberta , Assirati Giacomo , Olivieri Tiziana , Frassoni Samuele , Bagnardi Vincenzo , Guerrini Gian Piero , Di Sandro Stefano , Di Benedetto Fabrizio 
Published: February 2025

ABSTRACTIntroductionLiver transplantation (LT) is the sole curative option for liver failure and other primary liver conditions. However, the limited number of suitable donors compared with the growing number of patients requiring LT remains a leading cause of mortality among those on the waiting list. This has resulted in the expansion of criteria for donor eligibility. The sequential combination of ex situ reperfusion, dHOPE, and NMP helps reduce the occurrence of ischemia–reperfusion injury and assess organ viability prior to transplantation.MethodsThis is a retrospective, single‐arm, single‐center study including all cases of liver grafts that underwent sequential perfusion between October 2021 and July 2024. Eligibility criteria for sequential perfusion were extended criteria DBD with macrosteatosis > 35%, use of high‐dose vasopressors during donor ICU stay or episodes of cardiac arrest, hemodynamic instability during procurement, prolonged ischemia time for logistic reasons, as well as DCD showing prolonged fWIT, flow alteration during normothermic regional perfusion (NRP), and DCDs in Maastricht 2 class. Viability was assessed following the Groeningen group criteria.ResultsThirty‐three cases were included and 16 met the viability criteria at the end of the sequential perfusion and were transplanted. One patient developed an early allograft failure (EAF) and another a primary nonfunction (PNF). All the other patients had a regular postoperative course, with no retransplantation, 56% of the cohort showing no postoperative complication and all currently in good standing, median follow‐up 19 months (range 4–39).ConclusionsSequential dHOPE and NMP is a strategy that can help assessing both viability and functionality of liver grafts from high‐risk donors, expanding the donor pool and increasing the opportunities for patients on the waiting list to get a transplant.
Real‐World Utilization of Medications With Pharmacogenetic Recommendations in Older Adults: A Scoping Review
Authors: Ianni Bella D. , Yiu Chin Hang , Tan Edwin C. K. , Lu Christine Y. 
Published: February 2025

ABSTRACTPharmacogenetic testing provides patient genotype information which could influence medication selection and dosing for optimal patient care. Insurance coverage for pharmacogenetic testing varies widely. A better understanding of the commonly used medications with clinically important pharmacogenetic recommendations can inform which medications and/or genes should be prioritized for coverage and reimbursement in the context of finite healthcare resources. The aim of this scoping review was to collate previous studies that investigated the utilization rate of medications that could be guided by pharmacogenetic testing. Included studies utilized electronic medical records or claims data to assess pharmacogenetic medication prescription rates for older adults (≥ 65 years old). Identified pharmacogenetic medications were classified according to therapeutic class and assessed for actionability based on the Clinical Pharmacogenetics Implementation Consortium guidelines. Across the 31 included studies, analgesic (n = 29), psychotropic (n = 29), and cardiovascular (n = 27) therapeutic classes were most commonly investigated. Study populations were primarily generalized (48%); however, some studies focused on specific populations, such as, cancer (n = 6), mental health (n = 1), and nursing home (n = 2) cohorts. A total of 215 unique pharmacogenetic medications were reported, of which, 82 were associated with actionable pharmacogenetic recommendations. The most frequent genes implicated in potential drug–gene interactions with these actionable pharmacogenetic drugs were CYP2D6 (25.6%), CYP2C19 (18.3%), and CYP2C9 (11%). Medications most frequently prescribed included pantoprazole (range 0%–49.6%), simvastatin (range 0%–54.9%), and ondansetron (range 0.1%–62.6%). Overall, the frequently prescribed medications and associated genes identified in this review could guide pharmacogenetic testing implementation into clinical practice, including insurer subsidization.
Extremely Low‐Frequency and Low‐Intensity Electromagnetic Field Technology (ELF‐EMF) Sculpts Microtubules
Authors: Lobyntseva Alexandra , Ganaiem Maram , Ivashko‐Pachima Yanina , Barnstable Colin J. , Weisinger Batsheva , Parabucki Ana , Segal Yaron , Shohami Esther , Gozes Illana 
Published: February 2025

ABSTRACTAberrant microtubule dynamics coupled with a reduction in Tau‐microtubule interaction are at the core of neuronal injuries resulting in microtubule disruption and aggregates of abnormally phosphorylated Tau. These pathological Tau aggregates define tauopathies such as Alzheimer's disease (AD), as well as the pathological sequelae following traumatic brain injury (TBI), stroke and spinal cord injury (SCI). We hypothesized that differential applications of extremely low‐frequency and low‐intensity electromagnetic field (ELF‐EMF) will change microtubule function. To examine our hypothesis, we pre‐applied ELF‐EMF to a neuroblastoma neuronal cell line later exposed to 4 h of zinc intoxication, modelling Tau‐microtubule dissociation. ELF‐EMF (40 Hz and 1 G; multiple exposure schedules) enhanced microtubule dynamics and increased Tau‐microtubule interaction in the face of zinc toxicity. Complementing these preconditioning neuroprotective effects, concomitant 1 h treatment protocols comparing 3.9 or 40 Hz and 1 G exposure, indicated effects on Tau phosphorylation accentuated with 40 Hz and reduction in beta tubulin isotypes, depending on electromagnetic frequencies, most pronounced at 3.9 Hz. Our results discovered ELF‐EMF modulation on the microtubule cytoskeleton essential for brain health.
Partner strain and support associations with affective reactions to daily stressors
Authors: Witzel Dakota D. , Chandler Kelly D. , Geldhof John G. , Hooker Karen , Stawski Robert S. 
Published: February 2025

AbstractObjectiveWe aimed to understand how marital quality and gender influence affective responses to daily stressors (i.e., affective reactivity and residue).BackgroundAffective reactions are putative mechanisms through which daily stressors impact long‐term health and well‐being. Understanding which resilience or vulnerability factors (e.g., marital quality, gender) are associated with affective reactions is therefore crucial to promote healthy lives and aging.MethodData came from a subsample of married adults (N = 1,335) who participated in both the Midlife in the United States (MIDUS) Study and the associated National Study of Daily Experiences (NSDE). Participants rated their levels of strain and support with their partners in the MIDUS survey. As part of the NDSE, participants subsequently reported their affect and experience of daily stressors over 8 consecutive days.ResultsPartner strain significantly exacerbated associations between previous‐day stressors and negative affect (i.e., affective residue), but not same‐day stressor–affect associations (i.e., affective reactivity).ConclusionFindings from this study highlight the importance of marital quality for shaping daily stress and affective well‐being.ImplicationsCultivating couple relationship skills—including decreasing partner strain—in adulthood may provide a means to decrease affective reactions to daily stress and promote short‐ and long‐term health and well‐being.
Pemafibrate improves liver biochemistry and GLOBE scores in patients with primary biliary cholangitis: Nationwide, multicenter study by the Japanese Red Cross Liver Study Group
Authors: Tsuji Keiji , Tamaki Nobuharu , Kurosaki Masayuki , Mori Nami , Takaki Shintaro , Ohya Kazuki , Mashiba Toshie , Ochi Hironori , Kobashi Haruhiko , Ogawa Chikara , Nonogi Michiko , Yoshida Hideo , Akahane Takehiro , Kondo Masahiko , Kasai Toyotaka , Fujii Hideki , Uchida Yasushi , Arai Hirotaka , Tsuchiya Kaoru , Izumi Namiki 
Published: February 2025

AbstractAimWe aimed to evaluate the effect of pemafibrate, a selective peroxisome proliferator‐activated receptor‐α modulator, on patients with primary biliary cholangitis (PBC) complicated by dyslipidemia.MethodsIn total, 61 patients with PBC (Add‐on group: 33 patients on ursodeoxycholic acid [UDCA] + pemafibrate combination therapy; Switch group: 28 patients who switched from UDCA + other fibrates to UDCA + pemafibrate combination therapy) were included in the study. Changes in aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma‐glutamyl transferase (GGT), alkaline phosphatase (ALP), and GLOBE scores were retrospectively analyzed from 6 months before to 12 months after treatment. The POISE criteria were also used to evaluate the treatment efficacy after 12 months.ResultsAfter 12 months of UDCA + pemafibrate combination therapy, AST significantly decreased from 45 ± 3 to 28 ± 3 U/L (p < 0.05), ALT from 49 ± 5 to 32 ± 5 U/L (p < 0.005), GGT from 155 ± 223 to 91 ± 182 U/L (p < 0.005), and ALP from 1.4 ± 0.9 to 0.9 ± 0.8 × upper limit of normal (p < 0.0005) in all patients. ALT, GGT, and ALP levels were significantly lower after 12 months of UDCA + pemafibrate combination therapy in both the Add‐on and Switch groups. After 12 months of combination therapy, the mean GLOBE score of all patients significantly decreased from 0.37 to 0.01 (p < 0.05) and the percentage of patients with a GLOBE score of 0.3 or higher decreased.ConclusionsIn patients with PBC who showed an inadequate response to prior therapy, pemafibrate add‐on or switch therapy improved liver biochemistry and GLOBE scores. Pemafibrate may be useful as a second‐line drug when UDCA alone is inadequate, or as an alternative after combination therapy with other fibrates.
Prediction of early‐onset bipolar using electronic health records
Authors: Wang Bo , Sheu Yi‐Han , Lee Hyunjoon , Mealer Robert G. , Castro Victor M. , Smoller Jordan W. 
Published: February 2025

BackgroundEarly identification of bipolar disorder (BD) provides an important opportunity for timely intervention. In this study, we aimed to develop machine learning models using large‐scale electronic health record (EHR) data including clinical notes for predicting early‐onset BD.MethodsStructured and unstructured data were extracted from the longitudinal EHR of the Mass General Brigham health system. We defined three cohorts aged 10–25 years: (1) the full youth cohort (N = 300,398); (2) a subcohort defined by having a mental health visit (N = 105,461); and (3) a subcohort defined by having a diagnosis of mood disorder or ADHD (N = 35,213). By adopting a prospective landmark modeling approach that aligns with clinical practice, we developed and validated a range of machine learning models, across different cohorts and prediction windows.ResultsWe found the two tree‐based models, random forests (RF) and light gradient‐boosting machine (LGBM), achieving good discriminative performance across different clinical settings (area under the receiver operating characteristic curve 0.76–0.88 for RF and 0.74–0.89 for LGBM). In addition, we showed comparable performance can be achieved with a greatly reduced set of features, demonstrating computational efficiency can be attained without significant compromise of model accuracy.ConclusionsGood discriminative performance for models predicting early‐onset BD can be achieved utilizing large‐scale EHR data. Our study offers a scalable and accurate method for identifying youth at risk for BD that could help inform clinical decision‐making and facilitate early intervention. Future work includes evaluating the portability of our approach to other healthcare systems and exploring considerations regarding possible implementation.
Social media component effects: a commentary on Maheux et al. (2024)
Authors: Jensen Michaeline 
Published: February 2025

Maheux et al.s' annual review (2024) summarizes a rapidly evolving literature on the specific components (including content, features and functions) of social media that can help or hinder healthy adolescent development, highlighting how proposed effects of social media components appear to matter more for some adolescents than others. This commentary explores how conclusions of Maheux et al. (2024) can help shape future translational research on what components of social media may facilitate or undermine healthy adolescent development and who is most susceptible to these social media component effects. Future research must also address when and where social media components matter most, situating our understanding within temporal and physical context. Finally, the promise of future research is highlighted on why youth engage with social media components (motivations) and how specific components of social media exert their effects (mechanisms).
Efficacy of Microneedle Fractional Radiofrequency Combined With Topical Insulin for the Treatment of Facial Atrophic Acne Scars: A Split‐Face, Double‐Blinded, Randomized, Placebo‐Controlled Trial
Authors: Rattananukrom Teerapong , Tejapira Kasama , Pomsoong Cherrin , Ratanapokasatit Yanisa , Vachiramon Vasanop 
Published: February 2025

ABSTRACTIntroductionTopical insulin (TI) has been shown to enhance wound healing by promoting re‐epithelialization and collagen synthesis. However, there have been limited studies addressing its potential use in treating acne scars.ObjectivesTo assess the efficacy of combining TI with microneedle fractional radiofrequency (MFR) in the treatment of atrophic acne scars.Materials and MethodA split‐face, double‐blinded, placebo‐controlled trial involved 30 participants with atrophic acne scars. Each side of the participants' face was randomly treated with a combination of MFR and TI or a placebo every 4 weeks for four consecutive sessions.ResultsSignificant improvements in scar volume were observed, with statistical significance at week 12 for MFR combined with TI sides (baseline 18.22 ± 9.86 vs. 16.20 ± 8.58 mm3, p = 0.017) and at week 16 for MFR combined with placebo sides (baseline 18.02 ± 9.24 vs. 15.28 ± 8.21 mm3, p = 0.001). The TI sides exhibited a reduction of 46.77% ± 21.33% in Echelle d’ évaluation clinique des cicatrices d’ acne (ECCA) (p ≤ 0.001), while the placebo sides showed a reduction of 46.39% ± 20.14% in ECCA (p ≤ 0.001). There were no significant differences in melanin, and hemoglobin index between the two groups. No hypoglycemic symptoms were reported.ConclusionCombining topical insulin with MFR is safe and could accelerate the early acne scar improvement.
30% Supramolecular Salicylic Acid Improved Symptoms and Skin Barrier in Papulopustular Rosacea
Authors: Wang Zihan , Wu Yutong , Varkani Fatemeh Nozzari , Su Xian , Yang Ziping , Gao Xinghua , Zhang Li 
Published: February 2025

ABSTRACTBackgroundRosacea is a chronic skin condition that affects millions of people worldwide, and its management continues to pose a significant challenge in dermatology.AimIn this study, we investigated the efficacy and safety of 30% supramolecular salicylic acid (SSA) as a treatment for papulopustular rosacea, with a particular focus on improving skin lesions, reducing persistent erythema, and enhancing skin barrier function.MethodsThirty‐four patients diagnosed with papulopustular rosacea were randomly divided into an experimental group treated with 30% SSA and a control group receiving a placebo. Clinical outcomes were evaluated based on lesion reduction rates, investigator severity assessment (ISA) scores, VISIA red area scores, and skin barrier, including trans‐epidermal water loss (TEWL), sebum levels, stratum corneum hydration, and pH values.ResultsA total of 34 patients were collected for both the experimental and control groups, with no statistical differences in age or disease severity between the groups (p > 0.05). The effective rate was 68.75% in the experimental group (p < 0.01). After treatment, the ISA score was 1.75 ± 0.68 in the experimental group and 2.40 ± 0.83 in the control group, indicating significant improvement (p < 0.05). The improvement rate of the VISIA redness score was 25.1% in the experimental group (p < 0.01). Among the 17 patients who underwent skin barrier function testing. Skin hydration significantly improved on left cheek (p < 0.05), right cheek (p < 0.01), and nose (p < 0.05) after 30% SSA treatment in experimental group. Sebum levels were significantly reduced on both cheeks and forehead (p < 0.05). No statistical differences were observed in other locations. Skin TEWL and pH value showed no changes.Conclusion30% SSA reduced papules and pustules in rosacea, improved persistent erythema, and enhanced stratum corneum hydration in the 30% SSA‐treated group compared to the placebo group. No significant differences were observed in TEWL and skin pH values between the two groups. Our findings suggest that 30% SSA is an effective and safe option for managing papulopustular rosacea, offering a well‐tolerated alternative to traditional treatments.