bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eating behaviors of children with intestinal failure and those who achieve enteral autonomy: An observational cross‐sectional study
Authors: Pires Giovana Q. , Signorini Alana V. , Miller Cristina , Giesta Juliana M. , Ceza Marília R. , Adami Marina R. , Kieling Carlos O. , Goldani Helena A. S. 
Published: December 2024

AbstractBackgroundChildren with intestinal failure (IF) receiving prolonged parenteral nutrition (PN) are exposed to risk factors that predispose them to developing disordered eating behavior. This study aimed to assess the food interest patterns of PN‐dependent children with IF and those who achieved enteral autonomy (EA).MethodsA cross‐sectional study was conducted in children aged 1–14 years with IF currently receiving PN for >60 days and in children who achieved EA. The American Speech‐Language‐Hearing Association—National Outcomes Measurement System (ASHA‐NOMS) scale for oral feeding assessment and Children's Eating Behavior Questionnaire (CEBQ) for eating behavior were used. Children were divided into two groups, G1 (currently using PN) and G2 (achieved EA by discontinuation of PN), for the analysis of each subscale of the questionnaire. The PN dependency index (PNDI) was also assessed.ResultsFifty‐one children were evaluated, and the median (IQR) age was 47.0 (26.0–69.0) months. Thirty‐five (68.6%) children were in G1, and 16 (31.4%) were in G2. Children in G2 had better mean scores than those in G1 on the satiety responsiveness, food responsiveness, and enjoyment of food subscales. These scores were significantly different among children with high/moderate PN dependence compared with those with mild dependence or those who achieved EA.ConclusionCompared with children who achieved EA, those with PN‐dependent IF showed food avoidance patterns of less interest in and enjoyment of food. This pattern was more pronounced in those with moderate/high dependence on PN.
The Group‐basEd Telehealth behavioral WEight Loss Program Among Breast Cancer Survivors: A Pilot and Feasibility Study
Authors: Allison Kelly C. , McCuen‐Wurst Courtney , Raevsky Allie , Holmes Nathaniel , Goldbach Macy , Guerra Carmen E. , Rendle Katharine A. , Cadet Tamara J. , Krouse Robert S. , Tchou Julia 
Published: December 2024

ABSTRACTObjectiveObesity is related to the recurrence of breast cancer. In‐person groups or individual telephone counseling currently comprise the behavioral weight loss (BWL) programs tested for cancer survivors. Group support via telehealth may be convenient and provide support from fellow survivors, but feasibility, acceptability, and efficacy testing are needed.MethodsA single‐arm, 6‐month BWL program was conducted for female breast cancer survivors with an ECOG performance 0 or 1, BMI > 25 kg/m2, and > 6 months from completion of adjuvant chemotherapy and/or radiation treatment. Participants attended 22 video group sessions over 6 months, completing acceptability ratings, weight measurements, Patient Health Questionnaire (PHQ‐9), City of Hope Breast Cancer Quality of Life Scale (QOL), and International Physical Activity Questionnaire. Changes in survey scores and weight (last‐observation carried forward) and differences in outcomes by patients' race were computed with paired t‐tests, ANCOVAs and Chi‐square tests.ResultsTwenty‐one (5 Black, 15 White, 1 Asian American; Mean (SD) = 60.7 (11.6) years; BMI 33.1 (5.9) kg/m2) survivors enrolled with 90% retention and 81.3% of sessions attended. Acceptability ratings were high (all > 4 on a five‐point scale). Mean (SD) weight loss was 5.9% (5.2%), with 60% losing ≥ 5% of baseline weight; White participants lost 7.5% and Black participants lost 1.9% (p = 0.04). Significant improvements were observed in mood (PHQ‐9; p = 0.01) and physical wellbeing QOL (p = 0.01). Physical activity did not change.ConclusionThis telehealth group BWL program was feasible and acceptable for breast cancer survivors, yielding a clinically significant weight loss. Future studies should test this intervention in larger, more diverse samples.Trail RegistrationClinicalTrials.gov identifier: NCT04855552, posted April 22, 2021
Properties of poly(p‐phenylene benzobisoxazole) fiber, and advances in its surface modification to enhance fiber–matrix adhesion: A review
Authors: Tang Lin , Hu Qingyi , Li Lizhi , Jiang Jing , Chen Derun , Zhou Pengcheng , Liu Xi 
Published: December 2024

AbstractHigh‐performance polymer fibers, commonly used as reinforced fibers, have garnered significant attention across various scientific and industrial domains due to their extremely high tensile strength and excellent toughness. Notably, poly(p‐phenylene‐2,6‐benzobisoxazole) (PBO) fibers are hailed as the most advanced high‐performance fibers of the twenty‐first century, known for their exceptional mechanical properties, outstanding thermal stability, excellent flame retardancy, and chemical resistance, attracting considerable attention and favor from researchers. This review provides a comprehensive overview of the structure of PBO fibers and two synthesis methods of PBO polymers, detailing the properties of PBO fibers to offer valuable references for researchers in this area. This review highlights various techniques for modifying PBO fibers. Conventional methods can easily damage the structure of PBO fibers, resulting in difficulties in achieving the ideal mechanical properties of the corresponding composites. Surface coating modification can improve the surface roughness and reactivity of PBO fibers without compromising their structure. Additionally, the enhancement of interfacial compatibility for PBO fiber‐reinforced composites via introducing interfacial compatibilizers is analyzed in detail. Finally, the challenges and future prospects of PBO fibers are also discussed. This paper aims to provide theoretical guidance for fabricating PBO fibers and enhancing the interfacial bonding strength with resin matrices, thereby increasing their potential in advanced applications.Highlights
Structures and properties of PBO fibers are presented.
Recent advances for the surface modification of PBO fibers are reviewed.
Scientific problems for improving interfacial bonding are proposed.
Limitations, challenges, and development trends of PBO fibers are prospected.
Living a Cancer Surveillance Life: A Meta‐Ethnographic Synthesis of Everyday Experiences and Ambivalences for Women Living With Hereditary Risk of Breast and/or Ovarian Cancer
Authors: Gislinge Julie Isabelle Plougmann , Byrjalsen Anna , Naver Klara Vinsand , Clausen Helle Vibeke , Ravn Pernille , Petersen Kresten Rubeck , Wadt Karin , Wahlberg Ayo 
Published: December 2024

ABSTRACTObjectiveWomen with or at risk of hereditary breast‐ and ovarian cancer (HBOC) often live a surveillance‐focused life from young adulthood. As they navigate a life of heightened medical vigilance, or a “cancer surveillance life,” we explore how women with HBOC, as well as their partners and families, experience this particular kind of living through a thorough literature review of existing qualitative research.MethodsWe performed Boolean searches in PubMed, EMBASE, EBSCOhost, PSYCHinfo, Scopus, and Web of Science from April–May 2022, identifying 506 relevant articles. After eliminating duplicates and quantitative studies, we systematically analyzed 53 articles. Articles examining all aspects of living with HBOC were eligible for inclusion. Following quality assessment by a verified appraisal tool, 28 articles were included in this review. We undertook an “a‐lines‐of‐argument synthesis,” and identified key similarities across studies to highlight generalizable aspects of living with HBOC.ResultsWe discovered five central themes which capture the ambivalences experienced by women living with HBOC: (1) an unresolved balancing act regarding genetic testing (2) burdens of relaying genetic information within the family (3) experienced risk discrepancies (4) preservation of the self and: (5) unsettled reproductive feelings.ConclusionsLiving with HBOC is filled with ambivalences, which are critical for decision making concerning disclosing risks to family members and children, choosing between risk‐reducing surgeries or surveillance, and family planning. Healthcare professionals should be aware of these findings when counseling women and families with HBOC to provide the best support possible in navigating their unique kind of living.
Drug‐Use Safety Enhancement Model—Theory and Application
Authors: Dunbar Edward T. , Bartkowiak Ania , Brennan Alison L. 
Published: December 2024

ABSTRACTHarm reduction strategies mitigate the adverse effects of problematic drug use through overdose prevention, disease transmission reduction, and improved access to treatment resources. However, educational resources for safe drug use remain sparse and are predominantly focused on abstinence‐based approaches. This manuscript introduces the Drug‐Use Safety Enhancement Model (DUSEM), a comprehensive framework designed to foster informed and healthy relationships with drugs. Grounded in interdisciplinary research, DUSEM encompasses eight domains: knowledge, motivation, set (mindset), setting, dose, administration, recovery, and evaluation. Each domain offers practical strategies for educators, professionals, and drug consumers to enhance drug‐use safety. For the purpose of this analysis, “drugs” include all psychoactive substances regardless of whether they are legal in the United States. Our approach is rooted in the ethical, legal, and cultural practices common in the United States, particularly those related to best practices for providing care to people who use substances. The American context shaped how we understand and talk about drug use, which reflects the American reality of clinical practice in the fields of mental health and addictions. From the perspective of evaluation of the traditional, American conceptualization of the issues around drug use, our model's development acknowledges the need for a shift from outdated abstinence‐focused paradigms toward empowering individuals with informed practices for safer drug use. While serving as an educational guidepost, the model underscores the necessity for further research to refine its application, efficacy, and curriculum development. Helping professionals, such as teachers, counselors, social workers, and psychologists, can use this model in various educational, clinical, or institutional settings to help their audiences explore their own relationships with drugs. Ultimately, DUSEM aims to destigmatize drug use, foster healthier relationships with drugs, and improve safety for consumers.
Toward Equitable Health Care: Bridging the Gap in the Health of Incarcerated Individuals in Africa
Authors: Okunlola Praise Oyedepo , Babatunde Abdulhammed Opeyemi , Akoki David Mobolaji , Ilori Opeyemi Temitope , Femi‐Lawal Victor Oluwafemi , Abiona Favour Mofiyinfoluwa , Tundealao Samuel Tobi 
Published: December 2024

ABSTRACTThe situation of correctional facilities in African countries represents a critical threat to health due to overcrowding, poor living conditions, and limited access to medical services. With over 3000 facilities and nearly a million incarcerated individuals, the prevalence of health conditions such as HIV/AIDS, mental health disorders, and tuberculosis is alarmingly high. These conditions are exacerbated by physical and psychological abuse and inadequate healthcare infrastructure. Despite these challenges, the health needs of incarcerated individuals in Africa remain largely neglected. This article provides a review of the health status of incarcerated individuals in Africa, drawing on limited available data. Lessons from developed countries highlight the potential for effective interventions through structured healthcare programs and policies. Recommendations include adopting the World Health Organization (WHO) prison health framework, improving judicial efficiency to reduce overcrowding, ensuring healthcare is managed by health ministries, and establishing rehabilitation centers. These measures are crucial for integrating incarcerated individuals back into society and achieving equitable health coverage in Africa.
Reliability Analysis of Weighted‐k‐Out‐of‐n(G)‐Subsystem With Performance Sharing Considering Component Interdependence
Authors: Niu Jiaqi , Li Yan , Li Mengyuan 
Published: December 2024

ABSTRACTFailure mechanism and performance transmission patterns of systems become more complex due to the coupling relationship between components and the system structure. In order to improve the system reliability, a novel performance‐sharing model is proposed in this paper, which consists of weighted‐k‐out‐of‐n(G)‐subsystems in serial. The components within the same subsystem are dependent. Based on this model, the relevant definitions of performance surplus and deficiency are given, and the system reliability is developed. A new system reliability evaluation algorithm is proposed based on the Copula function and Lz‐transform method. Furthermore, the different influence of performance transmission capacity on system reliability is analyzed. Finally, an application example of a power generation system is given to illustrate the behavior of the proposed algorithm, and the dynamic reliabilities of the system under the dependence and independence of the components are compared and analyzed, so as to show the effectiveness of the method.
Artificial Humic Acid Diminishes the Effect of Drought on the Soil Microbiome
Authors: Hoefle Daniel , Sperber Sebastian , Marzban Nader , Antonietti Markus , Hoffmann Thomas , Wicaksono Wisnu Adi , Abdelfattah Ahmed , Berg Gabriele 
Published: December 2024

AbstractHumic substances have an enormous potential for regenerative agriculture to improve soil quality and plant growth. Recently developed technologies called hydrothermal humification enabled the conversion of waste into artificial humic acids, that would allow for sustainable and large‐scale applications. However, not much is known about the effect of artificially produced humic acid on the soil microbiome and its effect on drought‐exposed soil. Therefore, we studied the effect of drought stress and artificial humic acid on the soil microbiota in sandy soil in a controlled experimental design. Analyses of 16S rDNA amplicon libraries by bioinformatics and statistics revealed that both drought and artificial humic acid application influenced bacterial community composition significantly, but only artificial humic acid affected bacterial diversity. Bacterial families like Pseudomonadaceae, Peptostreptococcaceae and Moraxellaceae enriched under artificial humic acid conditions, suggest an adaptation and selection of the soil bacterial microbiome. Under drought stress, artificial humic acid treatment kept bacterial diversity stable in the changed bacterial community composition. We propose that artificial humic acid application in sandy soil can improve the soil bacterial community, diminish drought stress, favour plant growth‐promoting taxa, and bring enormous potential to sequestrate carbon in the soil.
Exploring the Antioxidant, Antimicrobial, Antidiabetic, and Anticancer Properties of Capsicum annuum L. (Samandağ Pepper): Biochemical and In Silico Insights
Authors: Tunç Tutku , Ozpinar Hulya , Koçyiğit Ümit Muhammet , ERKAN Sultan 
Published: December 2024

AbstractCapsicum annuum L. species from the Samandağ district of Hatay/Turkey was used in our study. Phytochemical analysis of seed and fruit ethanol extracts of this plant was carried out by GC‐MS method. Total Antioxidant Status (TAS) and Total Oxidant Status (TOS) levels were determined to calculate the Oxidative Stress Index to determine antioxidant activity. MIC method was used to evaluate antimicrobial properties against pathogenic bacteria and fungi. Anticancer activity was determined by the XTT assay on breast (MCF‐7), lung (A549) and brain (C6) cancer cells and healthy fibroblast (WI‐38) cell lines. The effects of the extracts on acetylcholinesterase and α‐amylase activities were investigated. It was found that C. annuum fruit extract had a lower OSI value than the seed extract. Fruit and seed extracts showed antimicrobial activity on microorganisms at MIC values of 200 µg/mL. Molecular docking studies were conducted to analyze the antibacterial properties of plant active ingredients. These studies are chemical components that are determined to be more abundant in the plant extract. Thus, it aimed to evaluate the effects of active compounds on various bacterial species. The results revealed the potential antibacterial properties of plants and provided important data that these ingredients can be used in future treatment methods. The anticancer activity in all cancer cell lines was very high in both seed and fruit extracts with a selectivity index (SI) well above SI ≥ 3. Furthermore, no deleterious effect on healthy fibroblast (WI‐38) cells was observed. The extracts were found to decrease acetylcholinesterase activity but increase α‐amylase activity. As a result, these plant extracts were found to have anticholinergic potential.
Construction of Sorafenib Tosylate and Etoposide‐loaded Liposomes: A Path to Precision Liver Cancer Therapy and its Apoptosis Induction
Authors: Ganesan Subbulakshmi , Upadhye Vijay J. , Sharma Nutan , Arora Arpit , Chinnathambi Arunachalam , Alharbi Sulaiman Ali , Hussein‐Al‐Ali Samer Hasan , Abudoleh Suha Mujahed , Thangavelu Indumathi 
Published: December 2024

AbstractNanotechnology is an effective tool in fighting against cancer, playing a crucial role in investigating and fabricating novel anticancer drugs. Recognizing the worldwide prevalence of cancer, we combined sorafenib tosylate (ST) and etoposide (ETP) within liposomes. We assessed their ability to kill human umbilical vein endothelial cells (HUVECs) and HepG2 liver cancer cells. The liposomes effectively contained ST and ETP, exhibiting a particle size distribution below 180 nm, a polydisperse index (PDI) below 0.2, a spherical shape, a strong negatively charged zeta potential, and encapsulation efficiencies of 59% for ST, 88% for ETP, and 57% for ST combined with 87% for ETP. The FTIR analysis indicates that the drugs were incorporated within liposomes. Encapsulation of the drugs in liposomes resulted in a more significant cytotoxic impact on HepG2 cells and a reduced cytotoxic impact on HUVECs. The morphological assessment of the HepG2 liver cancer cells was investigated using AO‐EB and Hoechst 33258 staining methods. Apoptosis mechanisms of HepG2 cells were examined by Annexin V and PI dual staining. Furthermore, the coadministration of ST and ETP, which were enclosed in liposomes, resulted in a synergistic impact on the drugs, leading to cell death by apoptosis.
Green Synthesis of Repotrectinib: Impact of Aqueous Micellar Media on Chemoenzymatic Transformations
Authors: Rajendra Gaikwad , Ganesh Krithika , Rajulu Govinda G. , Sambasivam Ganesh , Shivashankarappa Nagashree 
Published: December 2024

AbstractA greener, milder, and scalable route for the synthesis of the anticancer drug repotrectinib has been developed. The effect of aqueous micellar media on the synthesis of the key chiral amine intermediate followed by repotrectinib has been studied. The synthesis of 2‐[(1R)‐1‐aminoethyl]‐4‐fluorophenol ((R)‐1) from a commercially available ketone was carried out using the enzyme ATA‐025 in the surfactant TPGS‐750‐M, resulting in an 82% yield and an enantiomeric excess (ee) > 99%. This method avoids the use of expensive chiral auxiliaries and hazardous reagents. Furthermore, the chiral amine ((R)‐1) was used in the synthesis of repotrectinib in an aqueous medium, resulting in a high yield and an ee > 99%.
Nanopore Confinement Effect Mediated Heterogeneous Plasmonic Metasurfaces for Multifunctional Biosensing Interfaces
Authors: Wang Yindian , Mao Zhihui , Hu Xiaojun , Cao Jiarong , Gwak Juyong , Lee Jaebeom , Chen Hongxia 
Published: December 2024

AbstractPlasmonic metasurfaces (PMs) exhibit extraordinary optical response due to surface lattice resonance, which is crucial for realizing high‐performance photovoltaic device preparation. In this work, a nanopore confinement effect‐mediated MOF@UsAu is proposed as a novel PM heterojunction for photovoltaic interfaces. 2D MOFs have the unique advantage of a tunable and ordered porous structure. Its nanopore confinement effect regulates in situ synthesis of AuNPs on the MOF surface in dimensions and regions. The interface delocalization induced by work function matching and the Schottky barrier formed by band bending enhance the ordered LSPR and photovoltaic response of PM heterojunctions, achieving a significant enhancement of SPR interface plasma electric field. Based on the bi‐directional interaction design between the S‐shaped multifunctional peptide and MOF@UsAu, a PMs‐enhanced SPR biosensor is constructed for direct, real‐time, and ultrasensitive analysis of tumor exosomes. This study is the first to use 2D MOFs as substrates for constructing PMs and designing customized in situ synthesis strategies for specific application scenarios. It provides new ideas for the design of novel PMs and the construction of customized photovoltaic interfaces, expected to be extended to various types of photovoltaic device applications.
Tough and Functional Hydrogel Coating by Electrostatic Spraying
Authors: Wang Lei , Xue Yaoting , Li Siyang , Zhang Xiaochen , Miao Zhikun , Zeng Zehao , Ruan Dongrui , Shen Yifeng , Yuan Hui , Zhao Yukai , Li Dong , Luo Zisheng , Wong Tuck‐Whye , Li Tiefeng , Li Li , Yang Xuxu , Yang Wei 
Published: December 2024

AbstractHydrogel coatings impart superior surface properties to materials, but their application on large and complicated substrates is hindered by two challenges: limited wetting conditions and intricate curing processes. To overcome the challenges, lyophilized adhesive hydrogel powders (LAHPs) are developed, which consist of poly(acrylic acid‐co‐3‐(trimethoxysilyl)propyl methacrylate) crosslinked with chitosan. These powders are electrostatic sprayed onto substrates to address wetting issues and rehydrated to form bulk hydrogel coatings to circumvent curing challenges. This approach enables the application of hydrogel coatings with a smooth surface and adjustable thickness on various materials, irrespective of category, geometry, or size. The coatings exhibit remarkable mechanical properties (strength of 2.62 MPa, elastic modulus of 6.84 MPa, and stretchability exceeding 3 folds) and robust adhesion (adhesion energy ≈900 J m−2) through a three‐step bonding process involving electrostatic attraction, hydrogen bonding, and covalent bonding. Notably, these coatings confer multiple functional attributes to the substrate, including lubricity, hydrophilicity, nucleation inhibition, and pH‐responsive actuation. Moreover, incorporating LAHPs with functional agents or rehydrating with functional solutions opens possibilities for diverse functional hydrogel coatings, such as thermal responsiveness and NH3 indication. Leveraging the virtues of simplicity, flexibility, convenience, and broad applicability, this strategy presents an enticing pathway for the widespread applications of hydrogel coatings.