bluuebunny/crossref_metadata_2025_split huggingface dataset:
EDUKASI TEKNIK MEMERAH, MENYIMPAN DAN MENYIAPKAN ASI YANG BENAR PADA IBU MENYUSUI YANG BEKERJA DI SMAN I PAGELARAN
Authors: Widayati Wahyu Widayati 
Published: April 2021

ABSTRAK
Praktik ASI ekslusif masih jauh dari 90% di sebagian besar Negara berkembang, bahkan durasi menyusui sangat pendek dan data dari SDKI menunjukkan masih cakupan ASI ekslusif tahun 2012 di Indonesia baru mencapai 27%. Tingginya angka kegagalan menyusui pada ibu bekerja terjadi setelah selesai cuti bersalin terutama pada ibu menyusui yang bekerja disektor formal karena status kepegawaiannya mengikuti standar aturan hukum yang jelas bagi perkantoran atau perusahaan yang bersangkutan. Seperti pada SMA N 1 Pagelaran dimana terdapat 50% adalah pekerja ibu – ibu baik guru dan staf yang masih berada pada usia produktif dan menyusui. Pengabdian masyarakt ini bertyujuan untuk menuingkatkan pengetahuan ibu - ibu menyususi yang berkerja di SMA N 1 Pagelaran dengan tehnik demontrasi pemberian edukasi teknik memerah, menyimpan dan menyiapkan ASI yang benar. Hasil dari pelaksanaan pengabdian masyarakat ini adalah didapatkan bahwa sebagian besar peserta pengabdian masyarakat meningkat pengetahuannya tentang teknik memerah, menyimpan dan memberikan ASI kepada anaknya.

Kata Kunci : Edukasi Memerah, Menyimpan dan Menyiapkan ASI

ABSTRACT
The practice of exclusive breastfeeding is still far from 90% in most developing countries, even the duration of breastfeeding is very short and data from the IDHS show that exclusive breastfeeding in 2012 in Indonesia only reached 27%. The high rate of failure to breastfeed in working mothers occurs after maternity leave, especially for breastfeeding mothers who work in the formal sector because their employment status follows clear legal standards for the office or company concerned. As in SMA N 1 Pagelaran where 50% are working mothers, both teachers and staff who are still at the productive and breastfeeding age. This community service aims to increase the knowledge of breastfeeding mothers who work at SMA N 1 Pagelaran with dem,onstration technique, providing education on how to express, store and prepare correct breast milk. The result of the implementation of this community service participants have increased their knowledge of techniques for expressing, storing and giving breast milk to their children.

Keywords :Education Expressing, Storing and Preparing Breastmilk
Kesiapan Petugas dalam Peralihan Dokumen Rekam Medis Manual ke Paperless pada Unit Rekam Medis Puskesmas Kedungmundu Kota Semarang
Authors: M Anike Yulis , S Retno Astuti , Wulandari Fitria 
Published: April 2021

Pengelolaan dokumen dengan menggunakan sistem yang berbasis komputer/elektronik di sektor kesehatan yang sedang menjadi trend global adalah rekam medis elektronik (RME) yang merupakan sub sistem informasi kesehatan yang mulai banyak diterapkan di Indonesia, Adanya keterbatasan ruang penyimpanan rekam medis dan juga upaya rumah sakit untuk meningkatkan kualitas pelayanan maka manajemen rumah sakit atau tepta pelayanan kesehatan memilih untuk menerapkan Rekam Medis Elektronik. Tujuan dari penelitian ini adalah untuk mengetahui kesiapan petugas dalam masa peralihan dokumen rekammedis berbasis kertas (paper based) ke rekam medis berbasis komputer atau rekam medis elektronik (RME) Jenis penelitian adalah deskriptif dengan pendekatan kualitatif, sedangkan metode pengambilan data dilakukan dengan cara observasi dan wawancara secara langsung pada petugas di bagian rekam medis di Puskesmas Kedungmundu di kota semarang. Berdasarkan hasil wawancara kepada petugas dan observasi di tempat penelitian diperoleh hasil bahwa di Puskesmas Kedungmundu sistem paperless di SIMPUS masih sering terjadi eror yang disebabkan oleh sarana dan prasarana yang sudah ada namun belum maksimal yaitu jaringan internet yang buruk sedangkan intenet dalam SIMPUS terkadang eror dari Dinas, selain itu petugas di puskesmas yang berjumlah 5 orang juga masih belum familiar terhadap penggunaan simpus, oleh karena itu diperlukan pelatihan lebih lajut mengenai penggunaan simpus, dan perlunya chrosschek dari Dinas Kesehatan ke Puskesmas untuk memastikan bahwa simpus dapat berjalan dengan baik di Puskesmas.
Analisis Perilaku Pencegahan Skabies pada Santri Pondok Pesantren Nurul Huda Pringsewu Lampung
Authors: Samino Samino , Muhani Nova , Irmayanti Ade 
Published: April 2021

Skabies merupakan penyakit menular yang di sebabkan oleh tungau Sarcoptes Scabie. Terdapat 18 (72%) santri menyatakan bahwa skabies sangat mengganggu, dan 23 (92%) santri mengungkapkan bahwa menjaga kebersihan diri dapat mencegah terjadinya skabies. Tujuan penelitian diketahui hubungan sikap, norma subjektif dan persepsi terhadap perilaku pencegahan skabies pada santri pondok pesantren Nurul Huda Pringsewu Lampung. Penelitian kuantitatif dengan metode Cross Sectional. Populasi 531 dengan sampel 164 santri. Teknik pengambilan sampel menggunakan Purposive Random Sampling. Alat ukur kuesioner, analisis data menggunakan uji Chi Square, dengan CI 95%. Variabel independet sikap, norma subjektif dan persepsi, sedangkan variabel dependent perilaku pencegahan skabies. Hasil uji Chi Square menunjukan, ada hubungan antara sikap terhadap perilaku pencegahan skabies (p=0,01) namun, tidak ada hubungan antara norma subjektif terhadap perilaku pencegahan skabies (p=0,111) dan tidak ada hubungan antara persepsi terhadap perilaku pencegahan skabies (p=0,301). Dapat disimpulkan sikap menjadi penyebab perilaku pencegahan skabies sedangkan norma subjektif dan persepsi bukan menjadi penyebab perilaku pencegahan skabies pada santri. Disarankan bagi responden agar meningkatkan perilaku pencegahan skabies mandi 2x dalam sehari, selalu menjaga kebersihan diri dan menjaga kebersihan lingkungan.
Toplu Beslenme Hizmeti Veren Bir Kuruluşta Sunulan Menünün Sera Gazı Emisyon ve Su Ayakizi Düzeylerinin Mevsimlere Göre Değerlendirilmesi
Authors: Madalı Berna , Karabulut Ömer Faruk , Öztürk Elif Esra , Parlak Lütfiye , Erdinç Ayşe Şeyma , Dikmen Derya 
Published: April 2021

Amaç: Ankara’da bir devlet kurumunda planlanan bir yıllık menünün, sera gazı emisyon ve su ayakizi değerlerinin hesaplanması, mevsimlere göre menülerdeki farklılıkların değerlendirilmesidir.
Gereç ve Yöntem: Çalışmada, Eylül 2017–Ağustos 2018 tarihleri arasında sunulan dört kap set seçimsiz menülerin sera gazı emisyon ve su ayak izi değerleri hesaplanmıştır. Sera gazı emisyon ve su ayakizi değerleri, sistematik derleme sonucu elde edilen veriler LCA yaklaşımı (Life-cycle assessment; Yaşam Döngüsü Değerlendirmesi) kullanılarak hesaplanmıştır.
Bulgular: Çalışmada, bir yıl boyunca verilen menünün enerji içeriği günlük ortalama 1015.0±37.20 kkal, protein içeriği ortalama 34.4±1.30 g, karbonhidrat içeriği ortalama 91.2±4.95 g ve yağ içeriği ortalama 56.3±2.41 g olarak belirlenmiştir. Bir yıllık verilen menüde 184 farklı yemek çeşidine yer verilmiştir. Yaz aylarında balık yemeklerine hiç yer verilmemiştir. İlkbahar mevsiminde toplam sera gazı emisyonu (227.5 CO2 eşdeğeri/kg) en yüksek iken, kış aylarında (178.9 CO2 eşdeğeri/kg) ise en düşüktür. Su ayak izi düzeylerine bakıldığında da benzer şekilde, ilkbahar mevsiminde (167662.6 m3/ton) en yüksek, kış mevsiminde ise en düşük (146732.8 m3/ton) bulunmuştur. Sera gazı emisyonuna ve su ayakizine en fazla katkıyı küçük parça et yemekleri sağlamıştır.
Sonuç: Hayvansal kaynaklı besinlerin menüde fazla yer alması, su ayakizi ve sera gazı emisyon düzeylerinin artmasına neden olmaktadır. Menülerin planlanırken; mevsiminde ve yerel besinlerin verildiği, bitkisel ve hayvansal kaynaklı besinler açısından dengeli ve bireylerin gereksinimlerini karşılayacak özelliklerinin göz önünde bulundurulması gerekmektedir.
Invitation to Write Book Reviews and Library Research
Authors: Acob Joel Rey Ugsang , Sillehu Sahrir 
Published: April 2021

EDITORIAL

We need to inform you again that the Aloha International Journal of Multidisciplinary Advancement (AIJMU) has a mission to publish research results and ideas from various disciplines of science and technology. In this editorial, we constantly invite researchers and academics around the world to share their best papers in this journal. In April 2021, we invite authors to publish scientific papers which are a form of document study. In this case, we can accept articles from document studies in short form such as book reviews, but we also look forward to the presence of articles and long forms, such as library research.
Book review is a type of short paper (usually contains 1000 to 200 words), which contains a review of a book that the author considers interesting or important. In addition to the title, author and affiliation, this article consists of at least 4 important parts, namely an introduction, a review (a summary of the book's contents, strengths, weaknesses and suggestions if any), conclusions and references. However, authors may write in a different systematics as long as they do not go outside the principles of writing a book review.
Meanwhile, library research is one type of qualitative research that emphasizes data sources in the form of documents, although it can be strengthened by other data sources, for example the results of interviews. This type of paper is usually written in a large number of words, for example 4000 to 10000 words, depending on the rules of the journal. There are three main types of literature research: historical studies, biographical studies and document studies.
We hope that articles based on document studies will further enrich the database of scientific papers in this journal, which in turn can contribute to the development and advancement of science and technology.
Melatonin: Multi-Target Mechanism Against Diminished Ovarian Reserve Based on Network Pharmacology
Authors: Yang Liuqing , Xu Hongbin , Chen Yun , Miao Chenyun , Zhao Ying , Xing Yu , Zhang Qin 
Published: April 2021

BackgroundDiminished ovarian reserve (DOR) significantly increases the risk of female infertility and contributes to reproductive technology failure. Recently, the role of melatonin in improving ovarian reserve (OR) has attracted widespread attention. However, details on the pharmacological targets and mechanisms of melatonin-improved OR remain unclear.ObjectiveA systems pharmacology strategy was proposed to elucidate the potential therapeutic mechanism of melatonin on DOR at the molecular, pathway, and network levels.MethodsThe systems pharmacological approach consisted of target identification, data integration, network construction, bioinformatics analysis, and molecular docking.ResultsFrom the molecular perspective, 26 potential therapeutic targets were identified. They participate in biological processes related to DOR development, such as reproductive structure development, epithelial cell proliferation, extrinsic apoptotic signaling pathway, PI3K signaling, among others. Eight hub targets (MAPK1, AKT1, EGFR, HRAS, SRC, ESR1, AR, and ALB) were identified. From the pathway level, 17 significant pathways, including the PI3K-Akt signaling pathway and the estrogen signaling pathway, were identified. In addition, the 17 signaling pathways interacted with the 26 potential therapeutic targets to form 4 functional modules. From the network point of view, by regulating five target subnetworks (aging, cell growth and death, development and regeneration, endocrine and immune systems), melatonin could exhibit anti-aging, anti-apoptosis, endocrine, and immune system regulation effects. The molecular docking results showed that melatonin bound well to all hub targets.ConclusionThis study systematically and intuitively illustrated the possible pharmacological mechanisms of OR improvement by melatonin through anti-aging, anti-apoptosis, endocrine, and immune system regulation effects.
Hemodynamic and Non-Hemodynamic Components of Cardiac Remodeling in Primary Aldosteronism
Authors: Pan Chien-Ting , Wu Xue-Ming , Tsai Cheng-Hsuan , Chang Yi-Yao , Chen Zheng-Wei , Chang Chin-Chen , Lee Bo-Ching , Liao Che-Wei , Chen Ya-Li , Lin Lung-Chun , Chang Yi-Ru , Hung Chi-Sheng , Lin Yen-Hung 
Published: April 2021

ObjectivesPatients with primary aldosteronism (PA) have cardiac remodeling due to hemodynamic and non-hemodynamic causes. However, component analysis of cardiac remodeling and reversal in PA patients is lacking. We investigated components of cardiac remodeling and reversal after adrenalectomy in patients with aldosterone-producing adenoma (APA).MethodsThis study prospectively enrolled 304 APA patients who received adrenalectomy and 271 with essential hypertension (EH). Clinical, biochemical and echocardiographic data were collected in both groups and 1 year after surgery in the APA patients. The hemodynamic and non-hemodynamic components of left ventricular (LV) remodeling were represented by predicted left ventricular mass index (LVMI) (pLVMI) and inappropriately excessive LVMI (ieLVMI, defined as LVMI-pLVMI).ResultsAfter propensity score matching, 213 APA and 213 EH patients were selected. APA patients had higher hemodynamic (pLVMI) and non-hemodynamic (ieLVMI) components of LV remodeling than EH patients. In multivariate analysis, baseline pLVMI was correlated with systolic blood pressure (SBP) and serum potassium, whereas ieLVMI was correlated with log plasma aldosterone concentration but not blood pressure. Post-operative echocardiography was available in 207 patents and showed significant decreases in both pLVMI and ieLVMI after adrenalectomy. In multivariate analysis, ΔpLVMI was correlated with SBP, ΔSBP, and pre-operative pLVMI, whereas ΔieLVMI was correlated with Δlog aldosterone-to-renin ratio (ARR) and pre-operative ieLVMI.ConclusionsThis study concluded that extensive cardiac remodeling in APA patients occurs through hemodynamic and non-hemodynamic causes. Adrenalectomy can improve both hemodynamic and non-hemodynamic components of LV remodeling. Regressions of pLVMI and ieLVMI were correlated with decreases in blood pressure and ARR, respectively.
Exenatide Attenuates Non-Alcoholic Steatohepatitis by Inhibiting the Pyroptosis Signaling Pathway
Authors: Liu Yu , Wang Da-Wei , Wang Dan , Duan Bin-Hong , Kuang Hong-Yu 
Published: April 2021

Background/AimsExenatide is a glucagon-like polypeptide-1 analog, whose main clinical use is to treat type 2 diabetes. However, the mechanism of exenatide in mitigating non-alcoholic steatohepatitis (NASH) remains unclear. This study aimed to investigate the in vitro and in vivo effect of exenatide on NASH.MethodsLeptin receptor-deficient C57BL/KsJ- db/db male mice were fed with methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH, while oleic acid/LPS-treated HepG2 cells were used as an in vitro cell model. Exenatide (20 µg/kg/day, subcutaneous) and specific exenatide inhibitors (20 µg/kg/day, intraperitoneal) were used to determine the effects of exenatide on NASH.ResultsExenatide treatment inhibited the pyroptosis signaling pathway to attenuate NASH.ConclusionTo the best of our knowledge, this report provides the first evidence showing that exenatide attenuated NASH by inhibiting the pyroptosis signaling pathway. Exenatide thus has important pathophysiological functions in NASH and may represent a useful new therapeutic target.
Integrated Analysis Reveals Prognostic Value and Immune Correlates of CD86 Expression in Lower Grade Glioma
Authors: Qiu Huaide , Tian Wei , He Yikang , Li Jiahui , He Chuan , Li Yongqiang , Liu Ning , Li Jianan 
Published: April 2021

BackgroundCD86 has great potential to be a new target of immunotherapy by regulating cancer immune response. However, it remains unclear whether CD86 is a friend or foe in lower-grade glioma (LGG).MethodsThe prognostic value of CD86 expression in pan-cancer was analyzed using Cox regression and Kaplan-Meier analysis with data from the cancer genome atlas (TCGA). Cancer types where CD86 showed prognostic value in overall survival and disease-specific survival were identified for further analyses. The Chinese Glioma Genome Atlas (CGGA) dataset were utilized for external validation. Quantitative real-time PCR (qRT-PCR), Western blot (WB), and Immunohistochemistry (IHC) were conducted for further validation using surgical samples from Jiangsu Province hospital. The correlations between CD86 expression and tumor immunity were analyzed using the Estimation of Stromal and Immune cells in Malignant Tumours using Expression data (ESTIMATE) algorithm, Tumor IMmune Estimation Resource (TIMER) database, and expressions of immune checkpoint molecules. Gene Set Enrichment Analysis (GSEA) was performed using clusterprofiler r package to reveal potential pathways.ResultsPan-cancer survival analysis established CD86 expression as an unfavorable prognostic factor in tumor progression and survival for LGG. CD86 expression between Grade-II and Grade-III LGG was validated using qRT-PCR and WB. Additionally, CD86 expression in LGG with unmethylated O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter was significantly higher than those with methylated MGMT (P&lt;0.05), while in LGG with codeletion of 1p/19q it was significantly downregulated as opposed to those with non-codeletion (P&lt;2.2*10-16). IHC staining validated that CD86 expression was correlated with MGMT status and X1p/19q subtypes, which was independent of tumor grade. Multivariate regression validated that CD86 expression acts as an unfavorable prognostic factor independent of clinicopathological factors in overall survival of LGG patients. Analysis of tumor immunity and GSEA revealed pivotal role of CD86 in immune response for LGG.ConclusionsIntegrated analysis shows that CD86 is an unfavorable prognostic biomarker in LGG patients. Targeting CD86 may become a novel approach for immunotherapy of LGG.
Efficacy of PSMA PET-Guided Radiotherapy for Oligometastatic Castrate-Resistant Prostate Cancer
Authors: Henkenberens Christoph , Derlin Thorsten , Bengel Frank , Ross Tobias L. , Kuczyk Markus A. , Giordano Frank A. , Sarria Gustavo R. , Schmeel Leonard Christopher , Christiansen Hans , von Klot Christoph A. J. 
Published: April 2021

PurposeTo assess the outcome of radiotherapy (RT) to all PSMA ligand positive metastases for patients with castrate-resistant prostate cancer (mCRPC).Patients and methodsA total of 42 patients developed oligometastatic mCRPC and received PSMA PET-guided RT of all metastases. The main outcome parameters were biochemical progression-free survival (bPFS), and second-line systemic treatment free survival (SST-FS).ResultsA total of 141 PSMA ligand-positive metastases were irradiated. The median follow-up time was 39.0 months (12-58 months). During the follow-up five out of 42 (11.9%) patients died of progressive mPCa. Five out of 42 (11.9%) patients showed no biochemical responses and presented with a PSA level ≥10% of the baseline PSA at first PSA level measurement after RT and were classified as non-responders. The median PSA level before RT was 4.79 ng/mL (range, 0.4-46.1), which decreased significantly to a median PSA nadir level of 0.39 ng/mL (range, &lt;0.07-32.8; p=0.002). The median PSA level at biochemical progression after PSMA ligand-based RT was 2.75 ng/mL (range, 0.27-53.0; p=0.24) and was not significantly different (p=0.29) from the median PSA level (4.79 ng/mL, range, 0.4-46.1) before the PSMA ligand-based RT. The median bPFS was 12.0 months after PSMA ligand PET-based RT (95% CI, 11.2-15.8) and the median SST-FS was 15.0 months (95% CI, 14.0-21.5).ConclusionIn well-informed and closely followed-up patients, PSMA PET-guided RT represents a viable treatment option for patients with oligometastatic mCRPC to delay further systemic therapies.
Investasi Bisnis Porang di Perum Perhutani KPH Bondowoso Perspektif Hukum Ekonomi Syari’ah
Authors: Mohammad Samsul Arifin  
Published: April 2021

Dalam rangka meningkatkatkan sumber daya hutan, Perum Perhutani Bondowoso membuka kesempatan untuk melakukan mitra kerjasama. Dalam hal ini, PT Bumi Nusantara Coconut telah melakukan perjanjian kerjasama dengan Perhutani dan LMDH Sumber Mas yang berkongsi khusus pembibitan porang. Ada beberapa bentuk kemitraan bagi hasil pengelolaan sumberdaya hutan dengan proses dan ketentuan bagi hasil yang diatur dalam perjanjian, Pertama; Perum Perhutani dengan LMDH bagi hasilnya 70% LMDH, 30% Perhutani. Kedua; ketika melibatkan investor, bagi hasilnya 40% Perhutani, 40% Investor dan 20% LMDH sesuai kesepakatan perjanjian. Sementara, investasi bisnis porang yang terjadi di RPH Pakisan, ketentuan bagi hasilnya masih kurang jelas. Perhutani 30%, Investor 65%, sedangkan LMDH 5% sampai 10%, tergantung pemberian dari Perhutani. Dari hasil analisis data peneliti dapat menyimpulkan bahwa proses dan ketentuan bagi hasil investasi bisnis porang adalah sah, berdasarkan perjanjian kerja sama dan praktek yang terjadi dilapangan, karena tidak bertentangan dengan konsep hukum ekonomi syari’ah yang proses kegiatannya termasuk akad syirkah ‘inan.
Kata Kunci: Investasi, Bisnis Porang, Hukum dan Ekonomi Syari’ah.
Design and validation of the animal welfare scale: Emotional education of children to prevent abuse
Authors: Monzalvo Curriel Alicia , Torres Soto Nissa Yaing 
Published: April 2021

It is important to have reliable instruments that can evaluate the attitude towards animal welfare of elementary school students. The abuse or mistreatment of children towards vulnerable groups deserves full attention, therefore we emphasize that animals constitute a vulnerable group that needs further studies. This is a descriptive, cross-sectional and correlational study aimed to validate the design of a scale that measures the attitude towards animal welfare (ABA) in 100 students from fourth to sixth grade of elementary school. It includes children between 9 to 12 years old residents of communities in the state of Sonora, Mexico. The factor analysis yielded two factors that explain 39.32% of the total variance with a Keizer-Meyer-Olkin (KMO) index of 0.86 and high internal consistency index for the total scale (0.90) and the subscales. Additionally, the confirmatory factor analysis produced an adequate practical and statistical fit in the covariance model and the second order model. The covariance analysis also evidenced convergent and divergent validity. Comparison analyzes by groups showed that sex and school grade do not influence attitudes in favor or against the animal species. Finally, we found that older children living in an extended family develop better attitudes in favor of animal care and protection.