bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of various regimens of bioactive marine fish concentrate, glucosamine sulfate, and chondroitin sulfate in treating knee osteoarthritis
Authors: Rekalov D.G. , Daniuk I.O. , Kulinich R.L. , Tarasenko T.M. , Samofal E.Yu. , Akimov O.Ye. , Kostenko V.O. 
Published: January 2025

Background. Osteoarthritis (OA) is one of the most common joint diseases worldwide. The search for effective treatment regimens to reduce symptoms and improve joint function is essential. The purpose was to compare the effectiveness of different regimens of bioactive marine fish concentrate (BMFC) in the treatment of knee OA with oral glucosamine sulfate (GS) and chondroitin sulfate (CS). Materials and methods. The study involved 60 patients with stage II knee OA. The patients were divided into three groups: the first group received 1 ml of BMFC daily (20 injections), the second group received 2 ml every other day (10 injections), and the third group received GS and CS in tablet form. Clinical efficacy was assessed using the WOMAC scale on days 3, 7, 14, and 21. Results. In the group that received BMFC daily, pain decreased by 41.4 % on day 7 and by 58.7 % on day 21. Joint stiffness decreased by 51.9 %, and range of motion increased by 51.3 %. In the group receiving 2 ml of BMFC every other day, pain reduction was 37.1 % on day 7 and 55.7 % on day 21. Joint stiffness decreased by 49.2 %, and range of motion improved by 46.0 % by the end of treatment. Both BMFC groups demonstrated similar efficacy. Patients receiving GS and CS showed less pronounced improvements. Conclusions. Injectable BMFC demonstrated higher efficacy in treating OA compared to oral GS and CS. Both ­BMFC administration regimens (daily administration of 1 ml and administration of 2 ml every other day) proved effective in reducing pain, alleviating joint stiffness, and improving functional capacity. The 2 ml every-other-day regimen achieved comparable efficacy with fewer injections, enhancing convenience and improving adherence to therapy.
Assessment of the impact of surgical treatment of primary malignant bone tumors on the quality of life of patients in peacetime and in the realities of wartime in Ukraine
Authors: Drobotun O. , Ternovyy N. , Konovalenko S. , Khmel A. 
Published: January 2025

Background. The experience of researchers and clinicians in many clinics around the world shows that primary malignant bone tumors are one of the least studied groups of neoplasms, the diagnosis and treatment of which is a difficult task. The purpose was to assess the impact of surgical treatment of primary malignant bone tumors on the quality of life of patients in peacetime and in the realities of wartime in Ukraine. Materials and methods. Surgical treatment of 76 subjects with primary malignant tumors of the lower extremities (osteosarcoma and chondrosarcoma) was carried out: 32 patients were treated from 2019 to 2021, and 44 patients from 2022 to 2024. Patient’s quality of life index before and 3 weeks after surgical treatment was measured by the simplified version of the QLQ-C30 questionnaire, neurological component was evalua­ted according to our integrated version of the Hospital Anxiety and Depression Scale (HADS) for hospitalized cancer patients and the Montreal MoCA scale. Results. In the study group, the value of the quality of life index after treatment was 27.0 % higher than the value before treatment. In contrast, in the reference group, which shows data before the start of martial law, the value of the quality of life index increased after treatment by 114.5 %. In the reference group after treatment, the percentage of subjects with occasional anxiety decreased from 69 to 53 %, and with constant anxiety — by 3 times, that is, from 19 to 6 %; in the study group, the indices significantly did not change. The overall number of persons with anxiety remained unchanged at 84 %, while in the reference group, this index decreased from 88 to 59 %. Conclusions. Significantly higher results in improving the quality of life were demonstrated by the reference group — the value of the quality of life index of patients increased by 114.5 % after treatment. Among the neurological symptoms in the study group, anxiety prevails, the frequency of which did not decrease even after the treatment and remained unchanged at the level of 84 %, which also confirms the influence of chronic stress during the war.
Results of experimental modeling of stresses on fixators in metal osteosynthesis of transtrochanteric fractures
Authors: Kalashnikov A.V. , Sabarna Y.K.M. 
Published: January 2025

Background. In the world’s developed countries, mi­nimally invasive technologies for using the proximal femoral rod are widely implemented in treating fractures of the proximal femur. However, we did not find literature data on the stresses on the blocked intramedullary rod depending on the type of fracture due to АО (Association of Osteosynthesis) and variants of its distal bloc­king. The study aimed to carry out biomechanical mode­ling of stresses on various metal fixators in osteosynthesis for transtrochanteric fractures of type A1. Materials and methods. We used a model of the femur, in which fixing elements were implanted. Two types of fixators were used to fix the fragments — the DHS (dyna­mic hip screw) plate (option 1) and the proximal femoral nail (PFN, option 2) rod, which provide optimal biomechanical and biological conditions for fracture union. Calculations of stress-strain state by the finite element method were performed for the intact model with both types of fixators and then with fixators for transtrochanteric fractures type A1 and options for distal locking (without loc­king, 1 screw, 2 screws). It was determined that the minimum stress on the metal fasteners in their proximal parts was determined when using the DHS plate and the PFN rod in the version without the use of screws for distal locking. Results. Our results were significantly (p ≤ 0.05) different from the data when using a PFN rod with distal locking with 1 or 2 screws. There was no stress on the distal part of the metal retainers when the PFN rod was applied in the variant without the use of screws for distal locking. In contrast, the stress when the DHS plate was applied increased to maximum values of 57.18 MPa. It was determined that maximum but adequate micromobility was observed when using the PFN rod model in the version without the use of screws for distal locking. These micromovements will contribute to the improvement of reparative osteogenesis of patients with type A1 transtrochanteric fractures. Fixation that is too strong when using a DHS plate (1.95 mm) can lead to impaired reparative osteogenesis. Conclusions. The research will make it possible to determine a differentiated approach to treating patients with transtrochanteric fractures of the femur. It will improve the effectiveness of providing medical care to this severe category of patients.
Pengaruh Densitas Topografi Terhadap Ketelitian Model Geoid: Studi kasus Pulau Sulawesi
Authors: Heliani Leni Sophia , Noviantara Hendra 
Published: January 2025

Penentuan model geoid teliti penting untuk mendapatkan tinggi ortometrik dari tinggi Global Navigation Satellite System (GNSS). Salah satu faktor yang mempengaruhi ketelitian model geoid adalah densitas topografi. Umumnya, penentuan model geoid pada formula Stokes menggunakan densitas massa standar sebesar 2670 kg/m3. Namun, densitas topografi sesungguhnya bervariasi. Saat ini, tersedia model densitas global, salah satunya yang dibuat University of New Brunswick (UNB) dengan resolusi 30”. Penelitian ini bertujuan untuk menganalisis pengaruh penggunaan densitas topografi dari densitas standar dan model global UNB terhadap ketelitian model geoid yang dihasilkan. Pemodelan geoid menggunakan metode Kungliga Tekniska Högskolan (KTH), dengan studi kasus Pulau Sulawesi, salah satu pulau yang memiliki variasi topografi yang sangat tinggi. Hasil validasi menggunakan data co-site GNSS-levelling menunjukan perubahan ketelitian yang tidak signifikan pada level milimeter, untuk geoid menggunakan densitas standar (NStandar) dan model global UNB (NUNB). Nilai standar deviasi dan RMS dari model NStandar sebesar 12,65 cm. Sedangkan nilai standar deviasi dan RMS dari model NUNB sebesar 12,58 cm dan 12,59 cm. Hal ini dikarenakan titik-titik validasi terletak pada lokasi dengan topografi yang tidak terlalu bervariasi. Selanjutnya, dilakukan pendetailan hitung perbedaan nilai geoid NStandar dan NUNB, diperoleh selisih antara -20 s.d. 30 cm di wilayah pegunungan. Perbedaan dalam level desimeter ini menunjukan efek yang signifikan dari densitas topografi terhadap ketelitian geoid, sehingga tidak bisa diabaikan, terutama untuk wilayah dengan variasi topografi yang tinggi.
Tirzepatide Associated With Reduced Albuminuria in Participants With Type 2 Diabetes: Pooled Post Hoc Analysis From the Randomized Active- and Placebo-Controlled SURPASS-1–5 Clinical Trials
Authors: Apperloo Ellen M. , Tuttle Katherine R. , Pavo Imre , Haupt Axel , Taylor Rebecca , Wiese Russell J. , Hemmingway Andrea , Cherney David Z.I. , Sattar Naveed , Heerspink Hiddo J.L. 
Published: January 2025

OBJECTIVE
Tirzepatide, a long-acting, glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor agonist, reduced urine albumin-to-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) decline in people with type 2 diabetes and high cardiovascular risk in the SURPASS-4 trial. To examine the generalizability of these findings, we assessed change from baseline in UACR for tirzepatide (5, 10, and 15 mg) compared with active and placebo treatment in a broad population from the SURPASS-1–5 trials.

RESEARCH DESIGN AND METHODS
This post hoc analysis examined data from the overall pooled SURPASS-1–5 population and subgroups defined by baseline UACR ≥30 mg/g. A mixed model for repeated measures was used to analyze on-treatment data from baseline to the end-of-treatment visit. Study identifier was included in the model as a covariate.

RESULTS
The adjusted mean percent change from baseline in UACR for tirzepatide 5, 10, or 15 mg compared with all pooled comparators was −19.3% (95% CI −25.5, −12.5), −22.0% (−28.1, −15.3), and −26.3 (−32.0, −20.0), respectively, at week 40/42. Results were similar across pooled placebo, active, and insulin comparator studies. UACR lowering appeared more pronounced in subgroups with UACR ≥30 mg/g. Mediation analysis findings suggested that approximately one-half of the reduction in albuminuria associated with tirzepatide may be weight loss related. There was no difference in eGFR between tirzepatide and pooled comparators at week 40/42.

CONCLUSIONS
In this post hoc analysis in people with type 2 diabetes, including those with chronic kidney disease, tirzepatide was associated with a clinically relevant decreased UACR versus comparators, suggesting a potential kidney-protective effect.
Media Animasi Cerita Rakyat ‘Siap Sangkur Mataluh Mas’ Di Sekolah Dasar
Authors: I Made Dedy Setiawan  , Ni Komang Ayu Leonita  , I Ketut Setiawan  
Published: January 2025

Generasi muda saat ini kurang meminati cerita rakyat karena dianggap kurang relevan dengan perkembangan zaman. Padahal cerita rakyat merupakan salah satu karya sastra yang mempunyai nilai kearifan lokal. Menyikapi fenomena terkait popularitas cerita rakyat di kalangan siswa sekolah dasar, maka dipandang perlu adanya media pembelajaran alternatif. Media pembelajaran ini diharapkan bisa mengakomodasi siswa dalam melestarikan cerita rakyat sebagai salah satu kearifan lokal dan sumber pendidikan karakter di tengah pesatnya perkembangan teknologi. Subjek penelitian sebanyak 17 orang terdiri dari 2 orang guru sebagai ahli materi, 14 orang siswa kelas 3 SDN Kedewatan, dan seorang ahli media. Metode pengumpulan data menggunakan metode observasi, wawancara, kepustakaan, dan kuisioner. Analisis data kualitatif deskriptif digunakan untuk mengolah data observasi, wawancara, dan studi pustaka, sementara data kuisioner diolah secara kuantitatif. Implikasi penelitian ini adalah memberikan wawasan bagi para pendidik mengenai efektivitas media animasi sebagai alat bantu pengajaran yang menarik dan interaktif, khususnya dalam menyampaikan nilai-nilai budaya lokal kepada siswa. Tujuan penelitian ini adalah merancang media animasi cerita rakyat yang layak untuk diimplementasikan. Analisis data kualitatif deskriptif digunakan untuk mengolah data observasi, wawancara, dan studi pustaka, sementara data kuisioner diolah secara kuantitatif. Hasil penelitian menunjukkan bahwa media animasi sangat layak digunakan berdasarkan hasil uji ahli materi, uji coba kelompok, dan uji ahli media dengan kualifikasi sangat baik.
Keabsahan Permohonan Pailit dan PKPU oleh Pekerja sebagai Alternatif Penyelesaian Kegagalan Pembayaran Upah
Authors: Fanny Gresta Nova  
Published: January 2025

The increase in bankruptcy and The Suspension of Debt Payment Obligations (PKPU) cases in Indonesia occurs due to the failure to pay by the company, such as non-payment of debts to creditors or non-payment of workers' rights due to the company's declining financial situation. In addition, the increase in bankruptcy and The Suspension of Debt Payment Obligations cases is also supported by the requirements for filing bankruptcy applications which are very easy to fulfill. In the event that the debtor is a company, the applications for bankruptcy declaration can also be filed by workers because workers can be referred to as preferred creditors because wages and rights that have not been received by workers are debts that take precedence in payment. However, in relation to the failure to make payments by employers for wages or workers' rights, the applications for bankruptcy declaration by workers should be used as an ultimum remedium(the last resort), namely as a last resort for resolving the problem because if there is an industrial relations dispute between workers and company related to non-payment of wages or workers' rights, the state has provided legal remedies through the mechanism of Industrial Relations Dispute Settlement (PPHI). Based on this, the purpose of this paper is to find out whether the failure or inability of the company to make payments of wages or workers' rights can be resolved through the bankruptcy or The Suspension of Debt Payment Obligations instrument whereas as we know that rights disputes in labor disputes should be resolved through the Industrial Relations Dispute Resolution mechanism as stipulated in Law Number 2 of 2004 concerning Industrial Relations Dispute Resolution.
Veterinary technicians report in a survey how futile veterinary treatments contribute to their moral distress and impact their professional and personal lives
Authors: Peterson Nathan W. , Foltz Kelly , Moses Lisa , Boyd J. Wesley 
Published: January 2025

Abstract

OBJECTIVE
To document veterinary technicians’ (VTs’) experiences with medical futility and its subsequent impact on moral distress and attrition from the profession.

METHODS
A cross-sectional study using a 56-question web-based, confidential and anonymous survey was distributed through the National Association of Veterinary Technicians in America between January 19 and February 15, 2023.

RESULTS
There were 1,944 responses from approximately 8,500 members (22% response rate). Nearly all respondents (97.8%) reported having encountered futile treatments during their careers, with 94.7% having provided such treatments. Most respondents (83.7%) had been asked or directed to act against their conscience to provide futile treatments to terminally ill patients, with 80.8% having done so. Providing futile treatments resulted in moderate to severe stress in 76.9% of VTs surveyed; respondents reported experiencing negative emotional (96.6%) or physical responses (83.4%) associated with medically futile treatments. Nearly half (48.7%) have considered leaving their position due to moral distress associated with providing futile treatments, and 55.5% claimed to have firsthand knowledge of someone who has left the profession for the same reason.

CONCLUSIONS
Encounters with medical futility were a common occurrence among respondents. Furthermore, futile medical treatments caused a significant increase in moral stress for the VTs polled, which may contribute to professional attrition.

CLINICAL RELEVANCE
Targeting ways to mitigate moral distress due to experiences with futility may increase retention and career satisfaction of VTs.
Exploring Life’s Boundaries: Biosemiotics and the Challenge of Defining Life
Authors: Zengiaro Nicola 
Published: January 2025

Abstract
This article addresses the challenges of defining life by combining insights from biological and semi-otic perspectives. It explores the lexicographic complexity of defining life, analysing how definitions vary across scientific and philosophical contexts and how these definitions are shaped by cultural and ideological influences. The study highlights the importance of semiosis as a fundamental characteristic of living organisms, positioning biosemiotics as a fundamental framework for understanding life beyond mechanistic models, but also semiotics as a tool for unravelling scientific narratives. Historical and contemporary intentions to define the minimum threshold of complexity for life, highlighting how these efforts have evolved over time and their implications for modern biology. By examining different perspectives on the phenomenon of life and its intermediate forms, the article offers a critical and interdisciplinary approach to understanding life as a semiotic and interpretive process.
The fact that an everyday concept of life is richer than the biologic concept of life (in the sense of a greater semantic flexibility and its encompassing character of embracing normative, emotional, sacred, and other aspects of life) may lead us to pose a contra-factual question: Could other notions of life have become basic for biology had it not been developed in the shadow of a hegemony of a mechanicist ideal of science during the 19th and 20th centuries; i.e., could life have become conceived of as something different from merely complex organizations of material particles and their energetic relations? (Emmeche 1998: 4)
Clinical and Histopathological Characteristics of Biopsy-Proven Kidney Graft Rejection in Latvia
Authors: Muižniece Ieva , Kuzema Viktorija , Ziediņa Ieva , Pētersons Aivars , Jušinskis Jānis , Folkmane Inese 
Published: January 2025

Abstract
Kidney transplantation has become a preferred treatment for many patients with end-stage renal disease, leading to increased quality of life. In recent decades, results in kidney transplantation have been improving, but allograft rejection remains an important clinical problem. This retrospective study reviewed all kidney allograft biopsies performed at Pauls Stradiņš Clinical University Hospital from January 2014 to December 2022, with the aim to determine clinical and histopathological characteristics, treatment, and short-term outcomes of biopsy-proven kidney graft rejection in Latvia. Rejection was diagnosed according to clinical, laboratory, and biopsy-proven acute rejection histological criteria; classified and subdivided using Banff criteria (a total five groups). Treatment strategies, laboratory data at the time of biopsy and after one-year follow-up were analysed. A total of 153 allograft biopsies were included. The majority of the grafts were from deceased donors. Besides augmented maintenance immunosuppression for almost all patients, pulse steroids were the most administered treatment, followed by plasma exchange, rituximab, immunoglobulins, and anti-thymocyte globulin in different, mainly non-homogenous combinations. Acute antibody-mediated rejection was diagnosed most often. The most favourable outcomes considering allograft function were in the acute cellular rejection group after one-year treatment compared to the worst outcome chronic-active antibody mediated rejection (caAMR) group (p = 0.03). Furthermore, the caAMR group had the highest number of patients who returned to dialysis or died after one year.
Difficult airway predictors for anticipated or unanticipated difficult airway in patients with fibreoptic intubation: a retrospective observational study
Authors: Bērziņš Arvīds , Bīne Evita , Klucniks Andris , Vanags Indulis , Ozoliņa Agnese 
Published: January 2025

Abstract
Airway management is a cornerstone of anaesthesia. The aim of the study was to identify difficult airway (DA) predictors for patients with fibreoptic intubation (FOI). This retrospective cohort study included 135 adult patients undergoing general anaesthesia with the use of FOI at Rīga East University Hospital from 1 January 2018 to 31 December 2022. For analysis, 135 patients were divided into two groups according to unanticipated (un-DA, n = 33) or anticipated DA: (a-DA, n = 102). Data were analysed using SPSS 26.0, p < 0.05. FOI was used only in 135 cases of 50,186 general anaesthesia cases over the study period. Of 135 FOI cases, 75 (55.6%) were males with a median age of 62 ± 19 years; 24.4% FOI was used in acute and 75.6% in elective surgeries. Those with a-DA had a higher Mallampati score, on average 3.2 vs. 2.1, p = 0.002. Unanticipated DA were reported statistically more frequently in acute admission cases compared to elective surgeries — 39.3% vs 10.8% of cases. Previously known tracheal pathologies such as dislocation (p = 0.001) and stenosis (p = 0.011) were statistically reliable factors for the anticipated DA. Comparing a-DA and un-DA groups for combinations of predictors (Mallampati score, admission and tracheal pathology) we found a sensitivity and specificity 70.3% and 68.7% to predict DA. Mallampati score, acute admission, and previously known tracheal pathology are reliable predictors of DA in patients undergoing FOI. Acute admission had the greatest impact on unanticipated DA.
Faktor Risiko Terjadinya Osteoporosis pada Wanita Menopause
Authors: Renidayati Renidayati , Clara Clara , Sunardi Sunardi 
Published: January 2025

Two out of five Indonesian women have an increased risk of osteoporosis and are found in 85% of women who have undergone menopause for over 10 years. This study aims to determine risk factors for osteoporosis in postmenopausal women in Kelurahan Langgini Work Area, Bangkinang Health Center, Kampar Regency, Year 2010. The study design is a descriptive analytical approach with a cross-sectional method. The sample in this study consists of 51 postmenopausal women. Data processing is done using univariate and bivariate data analysis. The results show that 33.3% of respondents had osteoporosis, 33.3% of respondents have a skinny body type, 51.0% had low levels of physical activity (sports), and 54.9% had a poor diet. There is a significant relationship between body type, physical activity, and diet with the incidence of osteoporosis (P value 0.000 < alpha 0.05). The study recommends that the Chief of Bangkinang Health Center, Kampar Regency, establish a policy to conduct outreach programs for menopausal women as a routine health center activity. Additionally, nurses and midwives should provide education on the importance of physical activity (sports) and improvements in dietary habits for menopausal women.