bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of vitamin D receptor gene polymorphisms
with rheumatoid arthritis
Authors: Marquez Pete Noelia , Perez Ramirez Cristina , Maldonado Montoro Maria del Mar , Martinez Martinez Fernando , Fernández-Llimos Fernando , Sánchez Pozo Antonio , Ramirez Tortosa María del Carmen , Jiménez Morales Alberto 
Published: March 2021

IntroductionRheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown etiology which causes progressive deterioration
of the joints, leading to severe pain and functional disability. Vitamin D and
its receptor (VDR) play a significant part in the onset of autoimmune diseases such as RA. The purpose of this study was to evaluate the association
between VDR gene polymorphisms and risk of developing RA.Material and methodsA retrospective study was performed, including
214 RA cases and 748 controls of Caucasian origin. FokI (rs2228570), BsmI
(rs1544410), TaqI (rs731236), ApaI (rs7975232) and Cdx2 (rs11568820) gene
polymorphisms were analyzed by TaqManResultsThe recessive logistic regression model showed that the VDR FokIAA genotype was associated with lower risk of RA (p = 0.0255; OR = 0.58;
95% CI: 0.35–0.92). No other genetic polymorphism showed any association with RA in any of the models tested. Haplotype analysis revealed that
the haplotypes ACGAG (p = 0.033; OR = 1.62; 95% CI: 1.04–2.53) and GTGCA
(p < 0.01; OR = 2.77; 95% CI: 1.53–4.98) for BsmI, Cdx2, FokI, ApaI and TaqI
were associated with higher risk of RA.ConclusionsVDR FokI gene polymorphism showed a trend for risk of RA,
taking into account the variables of gender, age and tobacco use, and preventing false positives. Among our patients we found no influence of VDR
BsmI, TaqI, ApaI and Cdx2 on the risk of developing RA. However, haplotype
analysis indicated that the haplotypes ACGAG and GTGCA were associated
with higher risk of RA.
At what flow rate does the aortic valve gradient become severely elevated? Implications for guideline recommendations on aortic valve area cutoffs
Authors: Salahuddin Ayesha , Aronow Wilbert S. , Spevack Daniel M. 
Published: March 2021

IntroductionAortic stenosis (AS) is considered severe when the aortic valve area (AVA) is < 1.0 cm<sup>2</sup> and the mean aortic valve gradient (mAVG) exceeds 40 mm Hg. Since many patients with AVA < 1.0 cm<sup>2</sup> do not manifest an mAVG > 40 mm Hg, we sought to determine the AVA at which mAVG tends to exceed 40 mm Hg in a sample of subjects with varied transvalvular flow rates.Material and methodsOur echocardiography database was queried for subjects with native valve AS. We selected 200 subjects with an AVA < 1.0 cm<sup>2</sup>. The sample was selected to include subjects with varied mean systolic flow (MSF) rates. Linear regression was performed to determine the relationship between MSF and mAVG. Since this relationship varied by AVA, the regression was stratified by AVA (critical < 0.6 cm<sup>2</sup>, severe 0.6–0.79 cm<sup>2</sup>, moderately severe 0.8–0.99 cm<sup>2</sup>).ResultsThe study sample was 79 ±12 years old and was 60% female. The MSF rate at which mAVG tended to exceed 40 mm Hg was 120 ml/s for critical AVA, 183 ml/s for severe AVA and 257 ml/s for moderately severe AVA. Those with moderately severe AVA rarely (8%) had an mAVG > 40 mm Hg at a wide range of MSF. In contrast, those with severe AVA typically (75%) had mAVG > 40 mm Hg when MSF was normal (> 200 ml/s). Those with critical AVA frequently (44%) had mAVG > 40 mm Hg, even when MSF was reduced.ConclusionsSubjects with AVA of 0.8 and 0.9 cm<sup>2</sup> rarely had mAVG > 40 mm Hg, even when the transvalvular flow rate was normal. Using current guidelines, it is not clear if such cases should be classified as severe.
Lipoprotein(a) in an adult sample from the Russian
population: distribution and association
with atherosclerotic cardiovascular diseases
Authors: Ezhov Marat , Shalnova Svetlana , Elena B. Yarovaya Elena , Kutsenko Vladimir , Evstifeeva Svetlana , Metelskaya Victoria , Drapkina Oxana , Boytsov Sergey 
Published: March 2021

IntroductionLipoprotein(a) (Lp(a)) is recognized as an independent risk factor for atherosclerotic cardiovascular disease (ASCVD). The aim of this study
was to estimate the distribution of Lp(a) levels in working age adults from
the Russian population and to assess its association with ischemic heart
disease (IHD), myocardial infarction (MI), stroke, diabetes mellitus (DM), and
arterial hypertension (AH).Material and methodsThis substudy of the population-based study “Epidemiology of Cardiovascular Diseases and their Risk Factors in Some Regions
of the Russian Federation” (ESSE-RF) included 8461 subjects aged 25–64
years (63.7% women) without lipid-lowering drugs. Atherosclerotic cardiovascular disease was self-reported. Lp(a), apolipoproteins AI and B, and lipid
and glucose levels in blood serum were determined.ResultsThe prevalence of Lp(a) ≥ 30 mg/dl was 20.5% and 23.0%, and prevalence of Lp(a) ≥ 50 mg/dl was 13.3% and 15.2%, in men and women, respectively. An association of Lp(a) with IHD, MI, and AH, but not with stroke
and DM, was shown. A cut-off level of Lp(a) of 9 mg/dl was determined,
above which there was increased frequency of MI (by 59.2%, p = 0.02), IHD
(by 33.4%, p < 0.001), and AH (by 11.6%, p < 0.001). In the multivariate
analysis only the association of Lp(a) with IHD (1.19 (1.01–1.41), p = 0.038)
and MI (1.57 (1.06–2.38), p = 0.028) remained significant.ConclusionsLipoprotein(a) level ≥ 30 mg/dl was detected in every fifth
adult aged 25–64 years. Increased risk of MI and IHD starts at an Lp(a) serum level above 9 mg/dl.
Dihydromyricetin alleviates endothelial inflammatory response through IRE1α/NF-κB signaling pathway in sepsis
Authors: Wang Xifeng , Xu Xiaomin , Yang Yu peng , Xin Xin , Li Zekang , Wang Qimeng , Li Xiaoli , Hou Yun , Zhang Lianshuang 
Published: March 2021

IntroductionThe high mortality of sepsis is closely related to disorder of coagulation induced by endothelial inflammatory response. Our aim is to investigate the protective effects of Dihydromyricetin (DHM) on endothelial cells in sepsis and the endoplasmic reticulum (ER) stress mechanism.Material and methodsIn vivo, we conducted an animal study for which fifty male Wistar rats were randomly and equally divided into five groups: sham group, cecal ligation and puncture (CLP) group and three CLP+ DHM (50, 100, 150 mg/kg) groups, the DHM was orally administered 2 h after CLP for 3 days (once per day). In vitro, human umbilical vein endothelial cells (HUVECs) were treated with DHM (50μmol) for 24 h after stimulation by lipopolysaccharide (LPS). In the inhibition groups, reactive oxygen species (ROS) inhibitor N-acetylcysteine (NAC, 3 mmol) and endoplasmic reticulum (ER) stress inhibitor (STF-083010, 10 μmol) were incubated prior to LPS.ResultsOur results indicated that DHM (150 mg/kg) alleviated the histopathological injury of endothelium, decreased the release of inflammatory cytokines and adhesion molecules such as interleukin-1β (IL-1β), interleukin-6 (IL-6) , tumor necrosis factor alpha (TNF-α), vascular cell adhesion molecule 1 (VCAM-1) and endothelin-1 (ET-1), and inhibited the production of ROS production. In addition, we found that DHM ameliorated ER damage, significantly decreased the protein expressions of IRE1α/NF-κB signaling pathway.ConclusionsDHM treatment alleviated inflammatory response of endothelial cells in sepsis through the IRE1α/NF-κB signaling pathway triggered by oxidative stress. This study provided experimental rationale for the treatment of DHM on therapy of sepsis.
Clinical characteristics and outcome of 55 cases of hepatoblastoma relapses
Authors: Zhang Wei-ling , Hu Hui-min , Wang Yi-zhuo , Zhang Yi , Li Jing , Wen Yuan , Zhi Tian , Gao Ya-nan , Huang Dong-sheng 
Published: March 2021

IntroductionThis study aimed to analyse and summarize the clinical characteristics and prognosis of children with hepatoblastoma (HB) recurrence.Material and methodsFrom January 2009 to June 2018, the clinical data of 55 children with HB, who had recurrence after complete remission (CR), were collected and analysed.ResultsOf the 55 patients, the median duration of follow-up was 65 months, the median interval from CR to the first recurrence was 3 months, and the event-free survival (EFS) times were 42.00 ±4.72 months. For sites of recurrence, 24 patients had lung recurrence only, 6 patients had liver recurrence only, 18 patients had recurrence in both the liver and lung, and 7 patients had recurrence in other sites of the body (6 cases of brain and 1 case of mediastinum). The overall 5-year survival rate of 55 cases was 47.4% and the 5-year disease-free survival rate was 37.3%. According to the treatment after recurrence, the patients were divided into the combined treatment group (chemotherapy combined with surgery, 41 cases) and the chemotherapy alone group (14 cases). The 3-year overall survival rates were 75.2% and 17.1%, respectively, with statistical difference 2 = 28.441, p < 0.001. The EFS time and the 3-year EFS rate of the 2 groups was 55.04 ±4.10 months vs. 32.63 ±4.34 months; 70% vs. 55.7%, with significant difference 2 = 3.328, p = 0.0068.ConclusionsThe prognosis of recurrent HB is poor. The main sites of recurrence were lung and liver. After recurrence, chemotherapy combined with surgery can improve prognosis, and complete remission can be achieved.
Circ-VPS13C enhances cisplatin resistance in ovarian cancer via modulating miR-106b-5p/YWHAZ axis
Authors: Yao Hairong , Liu Dantong , Gao Fangyuan , Li Qian , Liu Shikai 
Published: March 2021

IntroductionOvarian cancer (OC) is the malignant tumor with the highest mortality among gynecological cancers. Chemotherapy resistance is a major obstacle to OC therapy. Circular RNAs (circRNAs) play crucial roles in cancer development and chemoresistance. However, the role and potential mechanism of has-circ-001567 (circ-VPS13C) in chemoresistance of OC remain unknown.Material and methodsThe levels of circ-VPS13C, miR-106b-5p and 14-3-3 zeta (YWHAZ) were detected by quantitative real-time polymerase chain reaction (qRT-PCR) or western blot assay. Cell Counting Kit-8 (CCK-8) assay was used to assess cell viability and calculate the half inhibition concentration (IC<sub>50</sub>) of cisplatin (DDP). The levels of autophagy-related markers were measured by western blot assay. Cell apoptosis and migration were evaluated by flow cytometry and transwell assay, respectively. The binding relationship between miR-106b-5p and circ-VPS13C or YWHAZ was confirmed by dual-luciferase reporter assay. Xenograft assay was performed to explore the role of circ-VPS13C in vivo.ResultsCirc-VPS13C and YWHAZ were up-regulated, while miR-106b-5p was down-regulated in DDP-resistant OC tissues and cells. Knockdown of circ-VPS13C enhanced DDP sensitivity by repressing autophagy in DDP-resistant cells. Circ-VPS13C increased DDP resistance via sponging miR-106b-5p. Moreover, miR-106b-5p directly targeted YWHAZ. Up-regulation of YWHAZ alleviated the decrease in DDP resistance caused by circ-VPS13C depletion. In addition, circ-VPS13C silencing decreased DDP resistance in vivo.ConclusionsCirc-VPS13C knockdown enhanced DDP sensitivity of OC through modulation of autophagy via the miR-106b-5p/YWHAZ axis, providing a new biomarker for improving the efficacy of OC chemotherapy.
Integrated analysis of microbiota with bile acids for
the phototherapy treatment of neonatal jaundice
Authors: Zhang Kun , Fan Sainan , Lv Anping , Ma Yanan , Fang Xiaohui , Zhang Jinping 
Published: March 2021

IntroductionInfant jaundice is a common condition which results from a high concentration of serum bilirubin. Phototherapy is a widely used treatment for bilirubin clearance. We analyzed the effect of phototherapy on intestinal flora and metabolism of newborns. The aim was to assess the benefit of treatment for hyperbilirubinemia with phototherapy.Material and methodsFifty-three jaundiced infants hospitalized at our neonatal intensive care unit were treated with phototherapy. Of them, 29 were prescribed antibiotics during the hospitalization. Fecal samples were collected before and 24 h and 48 h after phototherapy. The bacterial species and relative abundance were identified with Macrogene sequencing. The bile acids in feces were identified using liquid chromatography-mass spectroscopy (LC-MS).ResultsDifferential microbial species/genera and secondary bile acids were found after phototherapy. There are significant differences in the changes of the microbial species/genera between infants who did not receive antibiotic treatment and those who were given antibiotic treatment. Secondary bile acids were also significantly altered. At the same time, the differential microbial species/genera and the differential secondary bile acids interacted with each other.ConclusionsThis study identified several differential intestinal microbial species and secondary bile acids in fecal samples from infants with jaundice before and after phototherapy. Phototherapy can change the flora and its metabolism and its long-term impact needs further observation.
lncRNA ANRIL play an important role in renal injury induced by diabetes
Authors: Jiang Xiaoming , Su Nan , Ding Jiao , Jiang Juean , Yu Liqiang , Xie Yan 
Published: March 2021

IntroductionThe aim of this study was to discuss the effects and mechanisms of lncRNA in renal injury induced by diabetes by vivo and vitro study.Material and methodsCollecting healthy and DN patients, and measuring lncRNA ANRIL expression by RT-qPCR assay in serum. Measuring the ANRIL expression in normal, 10d and 20d model rats in kidney. Measuring LDH, MDA, SOD, IL-6 and TNF-α concentration by Elisa assay, evaluating the kidney pathology by HE staining, cell apoptosis by TUNEL assay, relative proteins expression by IHC assay and relative mRNA expression by RT-qPCR assay. In the cell experiment, Measuring LDH, MDA, SOD, IL-6 and TNF-α concentration by Elisa assay, measuring the cell proliferation by CCK-8, cell apoptosis by flow cytometry, relative mRNA and proteins expression by RT-qPCR and WB assay. The NF-κB(p65) nuclear volume of difference groups were evaluated by cell immunofluorescence.ResultsCompared with healthy people, lncRNA ANRIL was significantly increased in DN patients. Compared with sham group, the ANRIL expression, LDH, MDA, IL-6 and TNF-α concentration was significantly increased, SOD concentrations and cell apoptosis rate were significantly depressed with day increasing. TLR4, MyD88 and NF-κB(p65) mRNA and proteins expressions were significantly up-regulation.ConclusionslncRNA ANRIL knockdown had effects to improve renal injury induced by diabetes via regulation TLR4/NF-κB(p65).
Virtual reality versus Biodex training in adolescents with chronic ankle instability: a randomized
controlled trial
Authors: Shousha Tamer M. , Abo-zaid Nehad A. , Hamada Hamada , Abdelhamid Abdelsamee Mohamed Y. , Behiry Mohamed A. 
Published: March 2021

IntroductionAnkle instability is a common injury in athletes, affecting the quality of life, functional limitation, as well as static and dynamic balance. The aim of the study was to compare the efficacy of virtual reality and Biodex balance training in the treatment of ankle instability in adolescent athletes.Material and methodsNinety football players were enrolled in this study after the assessment of their eligibility. Their age ranged from 12 to 16 years. They were randomly allocated to three groups of equal numbers. Group 1 received a guideline protocol, group 2 received the same guideline protocol in addition to Wii Sport Training, and group 3 received the same guideline protocol in addition to Biodex balance training. All groups received treatment protocols three times a week for 3 months. Outcome measures included the stability indices (overall stability, anteroposterior stability, and mediolateral) measured by the Biodex Balance System as well as ankle instability measured by the Cumberland Ankle Instability Tool. Measurements were collected at the baseline and after 3 months of treatment.ResultsPost-treatment findings revealed a statistically significant decrease in the overall, anteroposterior, and mediolateral stability indices, as well as significant increase in Cumberland Ankle Instability outcomes of all groups (p < 0.05). On the other hand, there were no statistically significant differences between the virtual reality and Biodex balance training groups.ConclusionsVirtual reality training has a significant effect which appears to be similar to the Biodex balance training in adolescent athletes with chronic ankle instability.
PDGFRB knockdown rescues the efficacy of chemotherapy in metastatic gastric cancer patients
Authors: Tian Yang , Song Wei , Yang Shuping , Chen Zheng , Li Ming , Zhang Yan , Li Yanqing 
Published: March 2021

IntroductionThis study aimed to investigate the effect of PDGFRB on the efficacy of neoadjuvant chemotherapy (NAC) in metastatic gastric cancer (MGC).Material and methodsThe data from Gene Expression Omnibus (GEO) were analyzed to screen differentially expressed genes (DEGs). PDGFRB expression in cells were assessed by qRT-PCR and immunohistochemistry. Transwell, MTT and colony form assays were applied to determine the abilities of cell migration, cell invasion and cell proliferation. The association of core gene and PI3K/AKT pathway were identified through STRING database and western blot detection. Differences in overall survival (OS) among different patients were analyzed through Kaplan-Meier survival curve and prognostic factors were analyzed by Cox regression.ResultsHigh expression of PDGFRB and were found in gastric cancer through GEO data and MGC patients with combination chemotherapy resistance of docetaxel, cisplatin and S-1 (DCS therapy). Furthermore, the down-regulation of PDGFRB by PDGFRB shRNA or sunitinib malate could decrease cell migration, cell invasion and cell proliferation in resistant cells. Those findings were verified by in vivo experiments. Meanwhile, PDGFRB overexpression was accompany with the activation of PI3K/AKT pathway. In addition, the OS of patients in highly expressed PDGERB group were lower than that in lowly PDGFRB expressed group and PDGFRB, TNM staging and differentiation degree were the prognostic factors for MGC patients.ConclusionsPDGFRB knockdown could rescue the efficacy of chemotherapy in MGC and PDGFRB could serve as a novel marker for the prognosis of MGC.
1948 TÜRKİYE İKTİSAT KONGRESİ VE BASINA YANSIMASI
Authors: AYDIN Ayşe 
Published: March 2021

Türkiye Cumhuriyeti Devleti temellerini atmaya başladığı dönemde ekonomik kalkınmaya da büyük önem verdi. Çok erken tarihlerden itibaren ekonomik kalkınmada benimsenecek yol ve strateji konusunda çalışmalar yapıldı. 17 Şubat 1923’de İzmir İktisat Kongresi bu amacı gerçekleştirebilmek için toplandı. Kongrede alınan kararlar, hükümete ve Türkiye Büyük Millet Meclisi’ne gönderildi. Ayrıca kongrede alınan kararlar hükümet programında ve Cumhuriyet Halk Partisi programında da yer aldı ve uygulamaya konuldu. Genç cumhuriyetin yönetici kadrosu, özel sektörün ekonomik hayattaki eksikliğinden dolayı temel yatırım sayılabilecek alanları da kendi eliyle gerçekleştirmeye çalıştı. Bunda sermaye yokluğu, teknolojik yetersizlik ve müteşebbis düşüncenin henüz yeterince yerleşememiş olması da etkili oldu. Türkiye Cumhuriyeti Devleti, 1929 Dünya Ekonomik Krizi sonrası daha mutedil bir devletçiliğe yöneldi ancak bu da ekonomik kalkınmayı gerçekleştirmede yeterli olamadı.
1939-1945 yılları arasında yaşanan II. Dünya Savaşı ve sonrasında da Türkiye’nin ekonomik durumunun kötü olmasından dolayı İstanbul Tüccar Derneği yönetim Kurulu 29 Haziran 1948’de yaptığı toplantıda, ülkenin içinde bulunduğu ekonomik meseleleri incelemek ve çözüm önerilerinde bulunmak amacıyla İstanbul’da bir ticaret ve iktisat kongresi toplamaya karar verdi. Hazırlıklar tamamlandıktan sonra kongre, 22 Kasım’da açıldı. Kongreyi basın da yakından takip etti ve değerlendirmelerde bulundu. Kongreye daha önce kendileriyle görüşmeler yapılmış olmasına rağmen CHP iktidarı sıcak bakmadı ve katılmadı. Buna rağmen çok sayıda meslek kuruluşu, aydın ve sivillerin katıldığı kongrede, dış ticaret, vergi reformu, devletçilik gibi konularla ilgili komisyonlar oluşturularak altı gün çalışıldı. Ekonomide uygulanan devletçiliğin yanında serbest rekabete de fırsat tanınmasını ve bu konuda hükümetin istikrarlı ve güven verici bir konumda olması değerlendirilmesi yapıldı. Bu çalışmamızda dönemin kaynakları ve süreli yayınları öncelikli olarak taranarak, telif ve tetkik eserler de incelenerek konu değerlendirilecektir.
ATATÜRK’ÜN ÖLÜMÜNÜN TÜRK SOYLU ÜLKELERDEKİ BASINA YANSIMASI
Authors: YURDİGÜL Yusuf , YOĞURTÇU Gökçe 
Published: March 2021

Medya bir toplumun olaylara ve olgulara bakışını yansıtması bağlamında önemli araçlardan biridir. Mustafa Kemal Atatürk’ün ölümü de dönem itibarıyla dünyanın önemli olaylarında biridir. Bu doğrultuda çalışmanın temel amacı Türkiye Cumhuriyeti’nin kurucusu Mustafa Kemal Atatürk’ün ölümünün Türk soylu ülkelerin basınına nasıl yansıdığını tespit etmektir. Atatürk’ün ölümünün Avrupa ülkelerindeki yansımasına dair çalışmalar olmakla birlikte, kardeş ülkeler olan Kazakistan, Kırgızistan, Özbekistan, Türkmenistan ve Azerbaycan basınına yönelik bir çalışma bulunmamaktadır. Bu bağlamda çalışmanın ilgili alan yazınına katkı sunması amaçlanmaktadır. Bunun yanı sıra Atatürk’ün cenaze merasimine; Almanya, Belçika, Çin, Danimarka, İspanya, Mısır, Amerika, Fransa, Sovyetler Birliği ve İngiltere gibi uluslararası boyutta gerçekleşen katılım, Türkiye’nin dönemsel itibarını göstermesi bakımından da önem arz etmektedir. Merasime Türk soylu ülkelerden bir katılım olmamasına rağmen adı geçen ülkelerin dönem itibarıyla Sovyetler Birliği içinde yer aldıkları ve bağımsızlıklarını henüz kazanamamış oldukları bilinmektedir. Türk soylu ülkelerde yapılacak olan medya analizleri bu ülkelerdeki Türkiye algısını ortaya koyması açısından da önem arz etmektedir.
Atatürk’ün vefatının Türk soylu ülkelerin basınında nasıl sunulduğu sorusundan hareket eden bu çalışmada, ana dilde yayın yapan gazeteler örneklem olarak seçilmiştir. Bu doğrultuda “Kızıl Kırgızistan” (Kırgızistan), “Sosyalist Kazakistan” (Kazakistan), “Kommunist” (Azerbaycan), “Kızıl Özbekistan” (Özbekistan) ve “Sovyet Türkmenistanı” (Türkmenistan) gazetelerinin 10 Kasım 1938–30 Kasım 1938 tarihleri arasındaki sayıları taranarak Atatürk’ün vefatına yönelik haber metinleri kronolojik olarak başlık ve içeriklere göre incelemeye dahil edilmiştir. Gerek Sovyetler birliği döneminde gerek bağımsızlıktan sonra Türk soylu ülkelerin basını Türkiye’nin siyasî, ekonomik, kültürel hayatıyla yakından ilgilenmiştir. Mustafa Kemal Atatürk’ün vefatı ile ilgili haberler de 12 Kasım 1938 tarihinden itibaren Türk Soylu ülkeler basınına yansımaya başlamıştır. Analiz sonucunda elde edilen bulgular, Türkiye’nin Atatürk dönemindeki toplumsal, iktisadi ve kültürel reformlarının Kazakistan, Kırgızistan, Özbekistan, Türkmenistan ve Azerbaycan’da nasıl algılandığını ortaya koymaktadır. Atatürk’ün lider özelliklerinin ve dış ilişkiler konusundaki barışçıl diplomasisinin adı geçen ülkelerde nasıl görüldüğüne yönelik tespitlerin yanı sıra; Türkiye ile dostluk ilişkilerine yönelik bulgular mevcuttur.