bluuebunny/crossref_metadata_2025_split huggingface dataset:
Height Prediction Using the Knee Height Measurement Among Indonesian Children
Authors: Rumapea Fernando , Fadlyana Eddy , Dhamayanti Meita , Tarigan Rodman , Rahmayani Rahmayani , Rusmil Kusnandi 
Published: March 2021

Background: Height is essential for assessing growth and nutrition in children. Assessing height with appropriate measurement is important, although in certain physically disabled and hospitalized children direct height measurement is almost not possible. In these situations, segmental measurements can be used as proxy height. Knee height (KH) has been determined as the most reliable surrogate. Objective: This study aimed to establish a height-predicted equation using KH for use in both community and clinical practices. Methods: This was a cross-sectional study design that collected data from 1114 healthy children (596 boys and 518 girls) aged 7 to 12 years to develop the equations for predicting height from KH. A multiple linear regression analysis was used to develop the equations. Results: Two equations were established to predict height using KH: (1) for boys H = 29.895 + (0.081 × age [months] + (2.267 × KH)) and (2) for girls H = 26.297 + (0.110 × age [months] + (2.278 × KH)). The very high correlation between KH and actual height indicates a very strong agreement. Conclusions: Knee height can be used for prediction equations for height with a very good predictive power. The age variable using the month unit generates a more accurate equation.
Trends in Therapy and Outcomes Associated With Respiratory Failure in Patients Admitted to the Cardiac Intensive Care Unit
Authors: Jentzer Jacob C. , Alviar Carlos L. , Miller P. Elliott , Metkus Thomas , Bennett Courtney E. , Morrow David A. , Barsness Gregory W. , Kashani Kianoush B. , Gajic Ognjen 
Published: March 2021

Purpose: To describe the epidemiology, outcomes, and temporal trends of respiratory failure in the cardiac intensive care unit (CICU). Materials and Methods: Retrospective cohort analysis of 2,986 unique Mayo Clinic CICU patients from 2007 to 2018 with respiratory failure. Temporal trends were analyzed, along with hospital and 1-year mortality. Multivariable logistic regression was used to determine adjusted hospital mortality trends. Results: The prevalence of respiratory failure in the CICU increased from 15% to 38% during the study period ( P < 0.001 for trend). Among patients with respiratory failure, the utilization of invasive ventilation decreased and noninvasive ventilation modalities increased over time. Hospital mortality and 1-year mortality were 24% and 54%, respectively, with variation according to the type of respiratory support (highest among patients receiving invasive ventilation alone: 35% and 46%, respectively). Hospital mortality was highest among patients with concomitant cardiac arrest and/or shock (52% for patients with both). Hospital mortality decreased in the overall population from 35% to 25% ( P < 0.001 for trend), but was unchanged among patients receiving positive-pressure ventilation. Conclusions: The prevalence of respiratory failure in CICU more than doubled during the last decade. The use of noninvasive respiratory support increased, while overall mortality declined over time. Cardiac arrest and shock accounted for the majority of deaths. Further research is needed to optimize the outcomes of high-risk CICU patients with respiratory failure.
Impact of Clinical Pharmacy Services on Patient Management in the Chemotherapy Infusion Clinics: A 5-Year Study at a Comprehensive Cancer Center
Authors: Mashni Ola K. , Nazer Lama H. , Khalil Haya Z. , Dalbah Maha I. , Tuffaha Haitham W. , Rumman Asma T. , Jaddoua Saad M. 
Published: March 2021

Background: Chemotherapy requires careful dosing and monitoring and is associated with numerous adverse events. There is limited data describing the impact of clinical pharmacists in the chemotherapy ambulatory setting. Objective: This study aimed to evaluate the impact of clinical pharmacy services on patient management in the adult chemotherapy infusion clinics. Methods: This was a 5-year retrospective study that utilized the pharmacy electronic documentation system to determine the type of interventions and adverse drug events (ADEs) reported by the clinical pharmacists in the chemotherapy infusion clinics. Interventions were described based on the type of intervention and medication involved. ADEs were evaluated based on the type of ADE, the suspected medication, and the required management. Results: During the study period, 3,279 interventions and 1,445 ADEs were reported. The most common interventions involved dose adjustments (51%), followed by addition (23%) or discontinuation (21%) of prescribed medications. Carboplatin (20%) and zoledronic acid (14%) were the most common medications that required pharmacist interventions. The most common types of ADEs were hematologic (22%) and infusion-related reactions (20%). Docetaxel was the most common medication associated with ADEs (20%). Among the reported ADEs, most required adding supportive care (44%), followed by adjusting chemotherapy doses (22%). Conclusion: Clinical pharmacy services at the chemotherapy infusion clinics play an important role in optimizing the chemotherapy regimens as well as identifying and managing ADEs. Future studies should be directed to measure the impact of these services on patient outcomes as well as, physicians and pharmacy operational workload and cost savings.
Memory Complaints in Healthy Middle-Aged Adults Are Not Associated with Memory or Sustained Attention Performance
Authors: Quek Yi-En , Leuar Kok Hon , Saling Michael M. , Johnson Katherine A. 
Published: March 2021

Objective: To examine the associations between the number and type of memory complaints with memory and sustained attention performance in healthy middle-aged adults. Method: Sixty-six healthy individuals aged 35–64 years ( Mage = 47.73 years) were administered the seven Questions, Rey Auditory Verbal Learning Test, Sustained Attention to Response Task, and Depression Anxiety Stress Scales 21. Results: The number of memory complaints was not associated with memory or sustained attention performance but was associated with anxiety symptoms. The type of memory complaint was likewise not associated with memory or sustained attention performance. The complaints “recent change in ability to remember things” and “trouble remembering things from one second to the next” were associated with anxiety symptoms. Conclusion: Complaints about memory in otherwise healthy middle-aged adults do not reliably indicate memory or sustained attention performance. Rather, these complaints are more likely to be associated with heightened, but nevertheless subclinical, anxiety.
Chronic paronychia in cats with patellar fracture and dental anomaly syndrome
Authors: Pilot Mariette A , Bell Cynthia , O’Dair Hilary , Glenn Ellen J , Bailey Steven , Langley-Hobbs Sorrel J 
Published: March 2021

Case series summary The aim of this case series was to describe the clinical features and treatment of paronychia in cats diagnosed with patellar fracture and dental anomaly syndrome (PADS). Clinical records, photographs, microbiology, cytology and histopathology reports were collected, and follow-up was obtained. Five cats with paronychia were included. All five cats had multiple digits of multiple limbs affected and eventually underwent amputation of the third phalanx of one or multiple digits. A total of 36 digits were affected, 17% (n = 6/36) resolved with medical management and 83% (n = 30/36) were eventually treated successfully by amputation. The cats had treatment with numerous courses of antibiotics (range 7–20; mean 11 courses) over periods of time ranging from 10 to 67 months (mean 32 months). Relevance and novel information Chronic paronychia may be an additional clinical feature of PADS and the probable mechanism involves poor integrity of osteopetrotic bone, loss of normal nailbed anatomy and secondary osteomyelitis of the distal phalanx. Medical management with antibiotics, anti-inflammatory therapy and steroid treatment may improve the clinical signs in the short term; however, in severe instances, amputation of the third phalanx of the affected digit seems to be necessary to resolve repeated recurrences and discomfort. Additional information on the long-term outcome is required. In any cat with atraumatic patellar fractures and/or retained deciduous teeth, paronychia may require surgical management if medical management is unsuccessful.
Breathing places: Three filmmaking investigations
Authors: Rogers Christine , Gough-Brady Catherine , Berry Marsha 
Published: March 2021

Filmmakers and scholars Christine Rogers, Catherine Gough-Brady, and Marsha Berry each find a connection with place through their video work. In this article, they share their experiences of creating short videos, focusing on their insider experiences of filming and the spatial relationships between themselves and place. Although each of them began with a proposition, they filmed unscripted, allowing themselves to respond intuitively to their environment, allowing space in their practices for fluid and organic change and letting place shape what they filmed, and their final works. Christine Rogers engages with Elspeth Probyn’s idea of belonging as movement as she films Ngāi Tahu (Māori) traveling in dinghies away from her, toward islands where she, an outsider, cannot set foot. Catherine Gough-Brady finds a connection between non-representational theory and documentary film theory, uncovering a landscape that has no eye-line. Marsha Berry explores the seaside landscape, making a constellation with Rebecca Solnit’s lyrical essays about walking and place and non-representational theory as a mooring for her practice, exposing the common experience of standing still whilst looking at the blue horizon at sunset. Each filmmaker finds a unique path through the myriad of elements that make something a place.
Aflibercept or bevacizumab in combination with FOLFIRI as second-line treatment of mRAS metastatic colorectal cancer patients: the ARBITRATION study protocol
Authors: Ottaiano Alessandro , Scala Stefania , Santorsola Mariachiara , Trotta Anna Maria , D’Alterio Crescenzo , Portella Luigi , Clemente Ottavia , Nappi Anna , Zanaletti Nicoletta , De Stefano Alfonso , Avallone Antonio , Granata Vincenza , Notariello Carmen , Luce Amalia , Lombardi Angela , Picone Carmine , Petrillo Antonella , Perri Francesco , Tatangelo Fabiana , Di Mauro Annabella , Albino Vittorio , Izzo Francesco , Rega Daniela , Pace Ugo , Di Marzo Massimiliano , Chiodini Paolo , De Feo Gianfranco , Del Prete Paola , Botti Gerardo , Delrio Paolo , Caraglia Michele , Nasti Guglielmo 
Published: March 2021

Background: The intensive study of predictive factors has strongly ameliorated the therapeutic flow-chart of metastatic colorectal cancer (mCRC) by allowing the selection of patients who benefit from specific therapies. For instance, in mRAS (mutated RAS) mCRC patients, anti-EGFR drugs (cetuximab and panitumumab) are not recommended; in this group of patients, the use of anti-angiogenic drugs (bevacizumab and aflibercept) is predominant. However, at progression to standard bevacizumab-based first-line chemotherapy, still to date, there are no studies to guide oncologists in the choice of the best second-line anti-angiogenic drug (bevacizumab beyond progression versus aflibercept). Methods: ARBITRATION is a prospective, observational study assessing efficacy differences between second-line fluorouracil/irinotecan (FOLFIRI)/bevacizumab versus FOLFIRI/aflibercept at progression to fluoropyrimidines, oxaliplatin and bevacizumab in mRAS mCRC patients. A test power of 80%, a median survival of 9 months from second-line treatment start and a hazard ratio of 0.67 between the two schedules were the basis for statistical design. The final sample will be 220 patients (110 per treatment). The significance will be verified with a two-tailed log-rank test with an alpha value of the I-type error of 5%. Time-to-outcome will be described by Kaplan–Meier curves and prognostic factors studied through multivariable analyses based on the Cox model. Secondary objectives include safety, responses’ duration and progression-free survival. A translational research will be conducted to measure several angiogenic proteins in patients’ serum before starting the therapy in order to evidence any angiogenic factor patterns related to outcome. Discussion: We present a large, prospective, observational study aiming to answer two scientific questions: (1) outcome differences between second-line treatments with FOLFIRI/bevacizumab beyond progression versus FOLFIRI/aflibercept in mRAS mCRC patients, (2) angiogenic factors’ patterns that could associate with efficacy and help oncologists to apply best the therapeutic anti-angiogenic strategies. Trial registration: The ARBITRATION trial (version 0.0, 13 April 2020) has been registered into the clinicaltrials.gov registry on 20 May 2020 with identifier NCT04397601.
Real-world implementation of sequential targeted therapies for EGFR-mutated lung cancer
Authors: Magios Nikolaus , Bozorgmehr Farastuk , Volckmar Anna-Lena , Kazdal Daniel , Kirchner Martina , Herth Felix J. , Heussel Claus-Peter , Eichhorn Florian , Meister Michael , Muley Thomas , Elshafie Rami A. , Fischer Jürgen R. , Faehling Martin , Kriegsmann Mark , Schirmacher Peter , Bischoff Helge , Stenzinger Albrecht , Thomas Michael , Christopoulos Petros 
Published: March 2021

Background: Epidermal growth factor receptor-mutated (EGFR+) non-small-cell lung cancer (NSCLC) patients failing tyrosine kinase inhibitors (TKI) can benefit from next-line targeted therapies, but implementation is challenging. Methods: EGFR+ NSCLC patients treated with first/second-generation (1G/2G) TKI at our institution with a last follow-up after osimertinib approval (February 2016), were analyzed retrospectively, and the results compared with published data under osimertinib. Results: A total of 207 patients received erlotinib (37%), gefitinib (16%) or afatinib (47%). The median age was 66 years, with a predominance of female (70%), never/light-smokers (69%). T790M testing was performed in 174/202 progressive cases (86%), positive in 93/174 (53%), and followed by osimertinib in 87/93 (94%). Among the 135 deceased patients, 94 (70%) received subsequent systemic treatment (43% chemotherapy, 39% osimertinib), while 30% died without, either before (4%) or after progression, due to rapid clinical deterioration (22%), patient refusal of further therapy (2%), or severe competing illness (2%). Lack of subsequent treatment was significantly (4.5x, p < 0.001) associated with lack of T790M testing, whose most frequent cause (in approximately 50% of cases) was also rapid clinical decline. Among the 127 consecutive patients with failure of 1G/2G TKI started after November 2015, 47 (37%) received osimertinib, with a median overall survival of 36 months versus 24 and 21 months for patients with alternative and no subsequent therapies ( p = 0.003). Conclusion: Osimertinib after 1G/2G TKI failure prolongs survival, but approximately 15% and 30% of patients forego molecular retesting and subsequent treatment, respectively, mainly due to rapid clinical deterioration. This is an important remediable obstacle to sequential TKI treatment for EGFR+ NSCLC. It pertains also to other actionable resistance mechanisms emerging under 1G/2G inhibitors or osimertinib, whose rate for lack of next-line therapy is similar (approximately 35% in the FLAURA/AURA3 trials), and highlights the need for closer monitoring alongside broader profiling of TKI-treated EGFR+ NSCLC in the future.
Menstrual related discomfort and associated factors among undergraduate students in Ambo University, Central Ethiopia
Authors: Yirsaw Mesenbet Terefe , Wale Mengistu Zelalem 
Published: March 2021

Background: Menstruation is a natural phenomenon which is an indicator of women’s health that occurs throughout the reproductive years of every female. This phenomenon is unique to the females and governed by the girl’s general health condition, genetic, socioeconomic, and nutritional factors. Although it is a normal physiological process, most females experience some degree of pain and discomfort in their menstruation period. Even though there are limited studies so far reported about the issue in some other parts of the country, there is no scientific evidence in the present study area. Objective: To assess menstrual-associated discomfort and associated factors among undergraduate students in Ambo University, Central Ethiopia, 2018. Methods: Institution-based cross-sectional study was conducted at Ambo University from 30 March to 30 April 2018. Stratified sampling technique was used and 748 study participants were randomly selected from faculties using a multi-stage sampling procedure. Only data from 713 study participants were entered into EpiData 3.1 and analyzed using SPSS version 20.0 software. Logistic regression was used to associate factors with menstrual-associated discomfort. All statistical tests were considered as significant at a p-value of < 0.05. Result: The prevalence of menstrual-associated discomfort was found to be 68.6%. The variables age (Being younger) (adjusted odds ratio = 3.9 (95% confidence interval: 1.28, 11.78)), Tigire ethnicity (adjusted odds ratio = 2.4 (95% confidence interval: 1.02, 5.75)), unmarried (adjusted odds ratio = 2.1 (95% confidence interval: 1.21, 3.76)), smokers (adjusted odds ratio = 2.2 (95% confidence interval: 1.12, 4.29)), drinking caffeine (adjusted odds ratio = 1.8 (95% confidence interval: 1.17, 2.74)), amount of flow (adjusted odds ratio = 2.4 (95% confidence interval: 1.28, 4.62)), and duration of pain (adjusted odds ratio = 4.2 (95% confidence interval: 1.93, 9.29)) were significantly associated with menstrual-associated discomfort. Conclusion: This study revealed that majority of the participants was experienced with menstrual-associated discomfort. As the tendency of smoking cigarettes, drinking caffeine, and amount of flow is increased, menstrual associated discomfort is increased. Therefore, specific plan of action and support is urgently needed in order to enlighten and treat menstrual-associated discomfort.
Memory as the Aspatial Domain for the Perception of Certain Genres of Contemporary Art Music
Authors: Wanke Riccardo , Santarcangelo Vincenzo 
Published: March 2021

This paper enquires into the nature of the connections between memory and certain genres of contemporary art music whose unique features rely particularly on our early mnemonic processes. Specific sound configurations of this music are often associated, during listening, with visual and tactile sensorial qualities and with abstract geometries. They are perceived fundamentally as the results of acoustic-physical forces and energies and are organized according to Gestalt and kinesthetic principles. This kind of music calls for a specific listening attitude, which we define as the vertical stance, and seems particularly apt to respond to mechanisms of the working memory where echoic, short- and long-term memories assume a central role. In this vertical stance, memory is involved in the mental construction (segregation, storage, and prediction) of the Gestalt configurations of this music within a perceptual domain that crucially has no spatial connection to the external world. In tying in neurophysiological and psychological research with musicological theories, we discuss the perceptual approach to these music practices in the light of the philosophical concept of the ‘No-Space world’ as conceived by the philosopher Peter Strawson. We propose that – under certain conditions – memory may be the realm of the purely spectro-temporal features of music. The sound configurations of this music in particular are part of an internal-external perceptual framework, being decoded in the conceptual space of perception and able to elicit high-order recollections typical of an embodied engagement with the external world.
Establishment and associated factors of health records among young Chinese migrants
Authors: Shi Hong , Zhang Xiumin , Li Xiangrong , Ren Zheng , Zhao Hanfang , He Minfu , Fan Xinwen , Guo Xia , Zha Shuang , Qiao Shuyin , Li Yuyu , Pu Yajiao , Liu Hongjian 
Published: March 2021

Abstract
Background
Most Chinese migrants have been faced with obstacles to getting access to local public health services. Young migrants among internal migrants make a major contribution to the economy. However, the establishment of their health records has been ignored. This research was aimed at exploring the status and associated factors of the establishment of health records among young Chinese migrants.

Methods
Data were obtained from the 2017 China Migrants Dynamic Survey (CMDS). Chi-square test and binary logistic regression were performed to investigate the associated factors of the establishment of health records among young Chinese migrants.

Results
Approximately 30.2% of young migrants had their health records established in inflow communities. Urban residence, medical insurance (insured), and lower average monthly household income were attributed to the establishment of more health records. Young migrants who were in northeast China and across provinces and immigrated for working or engaging in trade were less likely to have health records established. Young migrants who participated in social activities and public affairs activities and took type of people in touch as natives in the inflow area showed a higher possibility of establishing health records. Meanwhile, receiving health education and hearing about national basic public health services (BPHSs) were beneficial for establishing the health records of more young migrants.

Conclusion
This study showed that the health records of young migrants had a relatively low establishment rate. Sociodemographic and migration characteristics, health status, public health services, and social integration factors were all related to the health record establishment of young Chinese migrants.
ModularBoost: an efficient network inference algorithm based on module decomposition
Authors: Li Xinyu , Zhang Wei , Zhang Jianming , Li Guang 
Published: March 2021

AbstractBackgroundGiven expression data, gene regulatory network(GRN) inference approaches try to determine regulatory relations. However, current inference methods ignore the inherent topological characters of GRN to some extent, leading to structures that lack clear biological explanation. To increase the biophysical meanings of inferred networks, this study performed data-driven module detection before network inference. Gene modules were identified by decomposition-based methods.ResultsICA-decomposition based module detection methods have been used to detect functional modules directly from transcriptomic data. Experiments about time-series expression, curated and scRNA-seq datasets suggested that the advantages of the proposed ModularBoost method over established methods, especially in the efficiency and accuracy. For scRNA-seq datasets, the ModularBoost method outperformed other candidate inference algorithms.ConclusionsAs a complicated task, GRN inference can be decomposed into several tasks of reduced complexity. Using identified gene modules as topological constraints, the initial inference problem can be accomplished by inferring intra-modular and inter-modular interactions respectively. Experimental outcomes suggest that the proposed ModularBoost method can improve the accuracy and efficiency of inference algorithms by introducing topological constraints.