bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urban-climate interactions during summer over eastern North America
Authors: Oh Seok-Geun , Sushama Laxmi 
Published: June 2021

Abstract
The urban heat island is a representative urban climate characteristic, which can affect heat-stress conditions and extreme precipitation that are closely connected with human life. Better understanding of urban-climate interactions, therefore, is crucial to ultimately support better planning and adaptation in various application fields. This study assesses urban-climate interactions during summer for eastern North America using regional climate model simulations at 0.22° resolution. Two regional climate model experiments, with and without realistic representation of urban regions, are performed for the 1981–2010 period. Comparison of the two experiments shows higher mean temperatures and reduced mean precipitation in the simulation with realistic urban representation, which can be attributed primarily to reduced albedo and soil moisture for the urban regions in this simulation. Furthermore, the mean temperature and precipitation in the simulation with improved urban representation is also closer to that observed. Analysis of short-duration precipitation extremes for climatologically different sub-regions, however, suggests that, for higher temperatures, the magnitudes of precipitation extremes are generally higher in the simulation with realistic urban representation, particularly for coastal urban regions, and are collocated with higher values of convective available potential energy and cloud fraction. Enhanced sea and lake breezes associated with lower sea level pressure found around these regions, contribute additional water vapor and further enhance dynamic convective development, leading to higher precipitation intensities. Analysis of temperature extremes clearly demonstrates that urban regions experience aggravated heat-stress conditions due to relatively higher temperatures despite reduced relative humidity. Double the number of extreme heat spells lasting six or more days are noted for the coastal urban regions in the study domain. This study, in addition to demonstrating the differences in urban-climate interactions for climatologically different regions, also demonstrates the need for better representation of urban regions in climate models to generate realistic climate information.
A Young Male with a Non-ST Elevation Myocardial Infarction and Polycythemia Vera
Authors: Ghori Firdous F. , Elyas Ahmed A. , Soliman Dina S. , Amer Alia M. , Arabi Abulrahman , Yassin Mohamed A. 
Published: June 2021

Abstract
Polycythemia Vera (PV) is a clonal myeloproliferative disease characterized by an erythroid dominant trilineage proliferation of hematopoietic precursor cells. Acute coronary syndrome is known to occur in patients with PV. However, there are very rare reported cases of myocardial infarction upon the initial presentation of PV. We present such a case of a 37 years old male, with no known cardiovascular risk factors, who had an initial presentation of NSTEMI treated with drug eluting stent (DES). Later investigations revealed a diagnosis of Polycythemia Vera. Treatment strategies for MI in cases of myeloproliferative disease lacking clear guidance, further studies are needed in this matter.
The Effect of Resveratrol on Aortic Function in Patients with Marfan Syndrome – Rationale and Design of the Resvcue Marfan Trial.
Authors: Andel Mitzi M van , Ooij Pim van , Scholte Arthur JHA , Berg Maarten P van den , Dickinson Michael G , Kimmenade Roland RJ van , Evertsz' Floor Bennebroek , Zwinderman Aeilko H , Mulder Barbara JM , Groenink Maarten , de Waard Vivian 
Published: June 2021

Abstract
Background Marfan syndrome (MFS) is a connective tissue disorder characterized by mutations in the fibrillin-1 (FBN1) gene. The most important manifestation is progressive enlargement of the aorta, ultimately leading to aortic dissection or rupture. Present day pharmacological treatment is based on drugs that decrease repetitive stress on the aorta and improve elastic properties and transport function of the aorta. Unfortunately, this is not sufficient for most patients and surgical resection and reconstruction of the enlarged part of the aorta is still necessary. We have shown earlier that the food supplement Resveratrol inhibits aortic growth and promotes aortic repair in a murine MFS model. Resveratrol is a natural polyphenol commonly found in the skin of berries and in nuts. Here, we hypothesize that Resveratrol treatment will also be protective against aortic dilatation and functional deterioration in humans with MFS. Methods/Design The RESVcue Marfan study is an investigator-initiated, prospective, pre-post observational, multicenter trial. Four specialized academic centers in the Netherlands will recruit 100 patients with genetically confirmed MFS. Patients will use Resveratrol for one year, on top of their ongoing medicinal regime. The primary endpoints consist of the following two main parameters; 1) aortic aneurysm expansion rate and 2) improvement of aortic functional indices. All indices will be measured before and after treatment by echocardiography and (4D flow) MRI. The 4D flow MRI allows for analysis of blood flow patterns and quantification of stresses on the aortic wall, distensibility and pulse wave velocity. Blood and skin samples will be taken to assess the effect of Resveratrol on potential biomarkers associated with Resveratrol metabolism and changes in the primary endpoints. Three psychological tests (The Well-being questionnaire (SF-12), the Hospital Depression and Anxiety Scales (HADS) questionnaire and the Checklist Individual Strength (CIS)) will be taken by the MFS patients to assess the effect of Resveratrol on their well-being. Discussion The RESVcue Marfan trial may provide sufficient data on beneficial effects of Resveratrol on aortic aneurysm expansion rate, aortic functional properties, and biomarkers in patients with MFS to justify a future randomized trial in a larger cohort for a longer study period.Trial registration NL66127.018.18, approved on 24 September 2018. https://www.toetsingonline.nl/ Resveratrol as potential aortic growth inhibitor in patients with Marfan syndrome.
Water Shortage Risk Considering Encounter Situation of Water Supply in Multi-Resource Water City
Authors: Dou Ming , An Chen , Zhang Jianling , Li Guiqiu 
Published: June 2021

Abstract
For multi-source water supply city, water supply varies due to different inflow conditions, which brings more uncertainty to water resources management. Therefore, it is necessary to scientifically evaluate and give countermeasures in advance. Based on the data sequence of Location, Yellow River and South-to-North Water Transfer in Zhengzhou from 1989 to 2018, the joint probability distribution model is constructed by using the optimized marginal distribution function and Copula function. The encounter probability is calculated, and the risk analysis is carried out according to the water shortage of each user under different encounters. The results show:①The probability of asynchronous is 85.96%, it is 71.92% higher than the probability of synchronous, which indicates that the three water sources complement each other well; ②Local water supply has the greatest impact on the risk of water shortage in Zhengzhou. Local water should be used reasonably and efficiently, and the external water source should be used as a supplement; ③The maximum encounter probability is 13.58%, all users except domestic water are in a water shortage state, the most serious water shortage in the industry is (-2.049, -1.089) billion m³. The minimum encounter probability is 1.14%, all users have different degrees of water shortage, the shortage of domestic water is (-3.037, 0.779) billion m³second only to industrial water shortage, the reservoir should be jointly dispatched and the groundwater exploitation should be increased to maintain the security of the urban water supply system and ensure the normal water use of social life.
25-hydroxycholesterol Regulates Migration, Invasion and EMT of Colorectal Cancer through miR-92a-3p/ACAA1/NF-κB Pathway
Authors: Wang Saisai , Fei Rushan , Xu Xijuan , Xu Jie , Yao Yuanyuan , Lu Jiying , Zheng Gang , Lu Sen , chen wenbin 
Published: June 2021

Abstract
Background: Colorectal cancer (CRC) is one of the most common malignances worldwide. Several studies suggest a positive association between high plasma cholesterol level and CRC. 25-hydroxycholesterol (25-HC) is enzymatically produced by cholesterol 25-hydorxylase in various organs and is involved in many processes. However, the critical role of 25-HC in the tumor growth and progression of CRC is largely unknown. Methods: CCK-8 assay, flow cytometry and Transwell migration and invasion assays were used to determine the effects of 25-HC on CRC cells proliferation, apoptosis and metastasis. Subcutaneous xenograft model and intra-splenic injection mouse model were established to investigate the effects of 25-HC on CRC in vivo. Immunohistochemistry staining was performed to determine the matrix metalloproteinases (MMPs) expressions in mice tumors and acetyl-CoA acyltransferase 1 (ACAA1) expression in human CRC tissues. The expressions of E-cadherin, N-cadherin and Vimentin were examined by immunofluorescent staining. MiR-92a-3p mimic, inhibitor and ACAA1 vector were constructed and transfected into LoVo cells. Results: 25-HC promotes CRC cells migration, invasion, and metastasis both in vitro and in vivo without affecting cells proliferation and apoptosis, accompanied by the upregulation of the expressions of MMPs and epithelial-mesenchymal transition (EMT) related markers. Mechanistically, miR-92a-3p expression is significantly elevated after 25-HC stimulation, while ACAA1 expression is down-regulated and negatively associated with tumor progression. Luciferase reporter assay confirms that miR-92a-3p could directly target ACAA1. Subsequent investigation indicates that nuclear factor (NF)-κB signaling is the downstream pathways of miR-92a-3p-ACAA1 axis in CRC cells. Conclusions: 25-HC promotes CRC cells metastasis by regulating cells migration, invasion and EMT through miR-92a-3p/ACAA1/NF-κB pathway.Trial registration: The current study was approved by the Ethics Committee of the First Affiliated Hospital, Zhejiang University on March22, 2018. The permission number was 2018-706 and 2020-1000.
Molecular Basis of Hyperammonemic Encephalopathy in Fibrolamellar Hepatocellular Carcinoma
Authors: Surjan Rodrigo Cañada Trofo , de Lima Thais Martins , Santos Elizabeth Santana dos , Silveira Sergio do Prado , Machado Marcel Cerqueira Cesar , de Souza Heraldo Possolo , ARDENGH Jose Celso 
Published: June 2021

Abstract
Purpose

hyperammonemic encephalopathy is a potentially fatal condition associated with fibrolamellar hepatocellular carcinoma. The mechanism involved in hyperammonemia in patients with fibrolamellar carcinoma was unclear until a possible physiopathological pathway was recently proposed. An ornithine transcarboxylase dysfunction was suggested as a result of increased ornithine decarboxylase activity induced by c-Myc overexpression. This c-Myc overexpression resulted from Aurora Kinase A overexpression derived from the activity of a chimeric kinase that is the final transcript of a deletion in chromosome 19, common to all fibrolamellar carcinomas.
Methods

we performed the analysis of the expression of all enzymes involved and tested for the mutation in chromosome 19 in fresh frozen samples of fibrolamellar hepatocellular carcinoma, non-tumor liver and hepatic adenomatosis.
Results

specific DNAJB-PRKACA fusion protein that results from the recurrent mutation on chromosome 19 common to all fibrolamellar carcinoma was detected only in the fibrolamellar carcinoma sample. Fibrolamellar carcinoma and adenomiomatosis samples presented increased expression of Aurora Kinase A, c-MYC and ornithine decarboxylase when compared to normal liver, while ornithine transcarbamylase was decreased.
Conclusion

The proposed physiopathological pathway is correct and that overexpression of c-Myc may also be responsible of hyperammonemia in patients with other types of rapidly growing hepatomas. This gives further evidence to apply new and adequate treatment to this severe complication.
Shared And Specific Patterns Of Structural And Functional Thalamo-Frontal Disturbances In Manic And Euthymic Pediatric Bipolar Disorder
Authors: Guo Yi-Bing , Gao Wei-Jia , Long Zhi-Liang , Cao Wei-Fang , Cui Dong , Guo Yong-Xin , Jiao Qing , Qiu Jian-Feng , Su Lin-Yan , Lu Guang-Ming 
Published: June 2021

Abstract
Bipolar disorder (BD) is clinically defined by alternating depressive and manic episodes with a separated period of euthymia. Thalamo-frontal loop plays vital role in psychotic symptoms, altered motor control and executive difficulties in BD. It remains unclear that structural and functional alteration of thalamo-frontal loop among the different mood states in BD, especially in pediatric BD(PBD).Twenty manic PBD(mPBD), 20 euthymic PBD(ePBD) and 19 healthy controls were included in the study. By analyzing the T1 images and fMRI signals, thalamus volume and frontal grey matter cortical thickness were tested, and functional connectivity(FC) between bilateral thalamus and frontal cortex was calculated. Relationship between clinical indices and thalamo-frontal FC was also evaluated in mPBD and ePBD adolescents.Compared to HCs, the cortical thickness of left MFG, bilateral superior frontal gyrus(SFG) was significantly decreased in both mPBD and ePBD patients, and volume of left thalamus and cortical thickness of right middle frontal gyrus(MFG) significantly decreased in mPBD patients. It was shown that thalamo-frontal hyperconnectivity with MFG in mPBD compared to HCs and ePBD subjects, and thalamo-frontal hypoconnectivity with precentral gyrus/SFG in ePBD subjects compared with that of HCs. In ePBD patients, episode times positively correlated with FC values between thalamus and precentral gyrusThe findings of the present study demonstrate detailed knowledge regarding shared and specific structural and functional disruption in thalamo-frontal loop in mPBD and ePBD subjects. Thalamo-frontal abnormalities reported in adult BD subjects were also observed in adolescent BD patients, and thalamo-frontal dysfunction may be a crucial treatment target in BD.
Analysis of Side Information Impact on the Coverage Region of Wireless Wiretap Channel
Authors: pakravan saeid , Hodtani Ghosheh Abed 
Published: June 2021

Abstract
Analyzing wireless communication performances by using information-theoretic results is of practical importance. In this paper, first, an achievable secrecy rate region and an outer bound on the secrecy capacity region for the discrete alphabet and memoryless wiretap channel with side information non-causally known at the transmitter are obtained. Then, by extending the results to the continuous alphabet wireless wiretap channel and by deriving a closed-form expression on the secrecy coverage region (SCR), as a remarkable wireless performance factor, impact of side information on the SCR is analyzed and it is shown that side information increases the SCR as expected intuitively. Numerical evaluation of theoretical results is done finally.
Community Psychological And Behavioural Responses To Coronavirus Disease 2019 Over One Year Of The Pandemic In 2020 In Hong Kong
Authors: Liao Qiuyan , Xiao Jingyi , Cheung Justin , Ng Tiffany W. Y. , Lam Wendy W. T. , Ni Michael Y. , Cowling Benjamin J 
Published: June 2021

Abstract
Background: Monitoring community psychological and behavioural responses to coronavirus disease 2019 (COVID-19) is important for informing policy making and risk communication to sustain public compliance with challenging precautionary behaviours and mitigating the psychological impacts. Methods: Monthly telephone surveys in January-April 2020 and then weekly surveys from May through December 2020 were conducted to monitor changes in public risk perception of COVID-19, personal efficacy in self-protection, confidence in the government’s ability to control the pandemic, precautionary behaviours, perceived impact of precautionary behaviours, psychological fatigue and distress in Hong Kong, and examine their inter-relationships. Results: While worry about contracting COVID-19 increased, personal efficacy and confidence in the government declined as the community incidence of COVID-19 increased. The public maintained high compliance with most precautionary behaviours throughout but relaxed behaviours that were more challenging when disease incidence declined. Public confidence in the government was persistently low throughout, of which, a lower level was associated with more psychological fatigue, lower compliance with precautionary behaviours and greater psychological distress. Perceived greater negative impact of precautionary behaviours was also associated with more psychological fatigue which in turn was associated with relaxation of precautionary behaviours. Female, younger and unemployed individuals reported greater psychological distress throughout different stages of the pandemic.Conclusions: Risk communication should focus on promoting confidence in self-protection and pandemic control to avoid helplessness to act when the pandemic resurges. Policy making should prioritize building public trust, enhancing support for sustaining precautionary behaviours, and helping vulnerable groups to adapt to the stress during the pandemic.
Advanced Magnetic Resonance Imaging (MRI) Characterization in Bickerstaff's Brainstem Encephalitis
Authors: Mao Yipu , Jiang Muliang , Long Liling 
Published: June 2021

Abstract
Purpose Bickerstaff's brainstem encephalitis(BBE) is considered a scarce variant of Miller-Fisher syndrome(MFS) and Guillain–Barré syndrome (GBS) but accounts for a significant proportion of brainstem encephalitis.Detailed knowledge of their neuroimaging manifestations is of paramount importance for a correct early diagnosis and proper management of the affected patients.In this study,We sought to characterize neuroimaging findings,including the morphology and manifestation of advanced MR imaging and differential diagnosis.Methods Seven BBE patients (5 males,2 females; mean age 42.5 ± 5.7 years,range 17 to 63 years) were retrospectively studied using conventional MRI (T1- and T2- weighted,FLAIR sequences,postcontrast T1-weighted images) and advanced MRI such as diffusion-weighted imaging (DWI) and proton magnetic resonance spectroscopy (MRS).The apparent diffusion coefficient (ADC) values and the MRS ratio were calculated in lesion regions.Results1. The distribution of these lesions typically include bilateral and symmetrical involvement of the mesencephalon,thalamus,tegmentum,infratentorial periaqueductal region,and the periventricular region surrounding the third and fourth ventricles involving white and gray matter; additional supratentorial white matter is not involved.2. MRI axial T2-weighted images and FLAIR sequences showed nearly symmetrical hyperintense signal changes with slightly spotty,patchy,or confluent homogeneous enhancement on postcontrast T1-weighted images without necrosis or hemorrhage.3. DWI signal was enhanced,and the apparent diffusion coefficient (ADC) map signal was slightly increased.ADC values of BBE lesions were in the range of 1.21 to 1.67 × 10−3 mm/s2 (mean 1.38 ± 0.66 × 10−3 mm/s2).4. Proton MR spectrum showed a slight increase in choline and a relative decrease in NAA peak,while Lipid and Lac doublet were not detected.Conclusion Advanced MRI imaging can provide important physiological and metabolic information of BBE and complement the morphological findings of the clinical conventional MRI.
Mangrove Health Assessment and Genetic Diversity of Associated Sesarmid Crab Parasesarma Persicum in Nayband National Park, Iran
Authors: Dehghani Maryam , Shadi Ahmad , Gandomi Yasaman , Ghasemi Ahmad 
Published: June 2021

Abstract
Mangrove forests as one of the most important coastal ecosystems provide important ecological and economic performance to the world, have been threatened by developmental human activities and subsequent land use changes. The present study aims to assess mangrove ecosystem health in Nayband Marine National Park, Iran using Mangrove Quality Index (MQI), in addition to analyse the effect of mangrove habitat quality on the genetic diversity of Parasesarma persicum the associated mangrove crab by amplified fragment length polymorphism (AFLP). Four stations were studied for mangrove quality index analysis as well as genetic analysis. The results of MQI survey based on hydrology, water, soil, biota criteria indicated moderate to low habitat quality of mangroves in the study area. Station 4 in the southern Nayband gulf showed highest impact by human activities and MQI of 0.7, indicating serious habitat alteration in this area. Station 2 in the northern part of Nayband gulf showed a moderate mangrove quality (MQI = 0.5). Based on the results of the AFLP genetic assessment, the estimated heterozygosity(He) of crabs was between 0.29 to 0.32 with a mean of 0.30. The highest genetic diversity was found at station 2, however, no complete population differentiation was observed between 4 stations. The analysis revealed a significant correlation between mangrove habitat alteration and heterozygosity reduction (P<0.05). Based on the results of the present study, mangrove habitat destruction due to anthropogenic activities may directly reduce the genetic diversity of associated species of this ecosystem.
DDX31: A Novel Functional Oncogene Promotes Migration and Proliferation of Pancreatic Cancer
Authors: Liu Yang , Xie Yongjie , Ding Jinsheng , Wu Liangliang 
Published: June 2021

Abstract
Purpose: Pancreatic cancer is one of the most malignant cancers with rapid disease progression. Pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% in exocrine pancreatic cancer. DDX31 is one of the Asp-Glu-Ala-Asp (DEAD)-box RNA helicases (DDX) family member, which has never been reported in pancreatic ductal adenocarcinoma. Through comprehensive analysis of bioinformatics screening, clinical pathological data and experiment results verification, we found DDX31 may be a promising oncogene.Patients and methods: The potential correlation between DDX3 expression and clinical feature of PDAC was analyzed, which revealed that patients with high DDX31 expression may have a poor prognosis. Elevated expression levels of DDX31 in PDAC compared with adjacent normal tissues were determined by immunohistochemical and Western blot analyses. Western blot analysis of N-cadherin, Snail, transwell, and wound healing assays was carried out to evaluate the pro-metastasis effects of DDX31 in PDAC. In vitro experiments included colony formation assay. Edu labeling assay, CCK-8, western blot analysis of Ki67, PCNA, and an in vivo subcutaneous mouse model were used to analyze the role of DDX31 in PDAC proliferation.Results: In our research, integrated bioinformatics analysis of the TCGA and GEO databases was performed to identify the metastasis and proliferation-related differentially expressed genes (DEG). DDX31 predicts strong metastasis and proliferation capacity of PDAC, was finally screened. Then, the clinical data identified that highexpression-DDX31 was correlated with pancreatic tumor size, pathological grade, and lymph node metastasis. The in vitro and vivo experiments revealed that overexpression-DDX31 promoted the migration, proliferation and cell viability of pancreatic cancer cells, these functions of DDX31 had also been proved in the knockdown results. Moreover, the EMT related markers and proliferation markers were identified to be positively regulated by DDX31 in pancreatic cancer cells.Conclusion: Thus, our work uncovered that DDX31 promotes migration and proliferation in PDAC and might be a promising therapeutic target in pancreatic cancer.