bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative image analysis in COVID-19 acute respiratory distress syndrome: a cohort observational study.
Authors: Dolinay Tamas , Jun Dale , Maller Abigail , Chung Augustine , Grimes Brandon , Hsu Lillian , Nelson David , Villagas Bianca , Kim Grace Hyun J , Goldin Jonathan 
Published: December 2021

Background Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury commonly associated with pneumonia, including coronavirus disease-19 (COVID-19). The resultant effect can be persistent lung damage, but its extent is not known. We used quantitative high resolution computed tomography (QHR-CT) lung scans to radiographically characterize the lung damage in COVID-19 ARDS (CARDS) survivors. Methods Patients with CARDS (N=20) underwent QHR-CT lung scans 60 to 90 days after initial diagnosis, while hospitalized at a long-term acute care hospital (LTACH). QHR-CT assessed for mixed disease (QMD), ground glass opacities (QGGO), consolidation (QCON) and normal lung tissue (QNL). QMD was correlated with respiratory support on admission, tracheostomy decannulation and supplementary oxygen need on discharge. Results Sixteen patients arrived with tracheostomy requiring invasive mechanical ventilation. Four patients arrived on nasal oxygen support. Of the patients included in this study 10 had the tracheostomy cannula removed, four remained on invasive ventilation, and two died. QHR-CT showed 45% QMD, 28.1% QGGO, 3.0% QCON and QNL=23.9%. Patients with mandatory mechanical ventilation had the highest proportion of QMD when compared to no mechanical ventilation. There was no correlation between QMD and tracheostomy decannulation or need for supplementary oxygen at discharge. Conclusions Our data shows severe ongoing lung injury in patients with CARDS, beyond what is usually expected in ARDS. In this severely ill population, the extent of mixed disease correlates with mechanical ventilation, signaling formation of interstitial lung disease. QHR-CT analysis can be useful in the post-acute setting to evaluate for interstitial changes in ARDS.
Women’s views and experiences of augmentation of labour with synthetic oxytocin infusion: a protocol for a qualitative evidence synthesis
Authors: Alòs-Pereñíguez Silvia , O'Malley Deirdre , Daly Deirdre 
Published: December 2021

Background: Augmentation of labour (AOL) is the most common intervention to treat labour dystocia. Previous research reported extensive disparities in AOL rates across countries and institutions. Despite its widespread use, women’s views on and experiences of intrapartum augmentation with infused synthetic oxytocin are limited. Methods: A qualitative evidence synthesis on women’s views and experiences of AOL with synthetic oxytocin after spontaneous onset of labour will be conducted. Qualitative studies and studies employing a mixed methods design, where qualitative data can be extracted separately, will be included, as will surveys with open-ended questions that provide qualitative data. A systematic search will be performed of the databases: MEDLINE, CINAHL, EMBASE, PsycINFO, Maternity and Infant Care and Web of Science Core Collection from the date of inception. The methodological quality of included studies will be assessed using the Evidence for Policy and Practice Information and Co-ordinating Centre’s appraisal tool. A three-stage approach, coding of data from primary studies, development of descriptive themes and generation of analytical themes, will be used to synthesise findings. Confidence in findings will be established by the Grading of Recommendations Assessment, Development and Evaluation-Confidence in the Evidence from Reviews of Qualitative research. Discussion: This qualitative evidence synthesis may provide valuable information on women’s experiences of AOL and contribute to a review of clinical practice guidelines for maternity care providers. PROSPERO registration: CRD42021285252 (14/11/2021)
Cost-effectiveness of cryptococcal antigen screening at CD4 counts of 101–200 cells/µL in Botswana
Authors: Tenforde Mark W. , Muthoga Charles , Ponatshego Ponego , Ngidi Julia , Mine Madisa , Greene Greg , Jordan Alexander , Chiller Tom , Larson Bruce A. , Jarvis Joseph N. 
Published: December 2021

Background: Cryptococcal antigen (CrAg) screening in individuals with advanced HIV reduces cryptococcal meningitis (CM) cases and deaths. The World Health Organization recently recommended increasing screening thresholds from CD4 ≤100 cells/µL to ≤200 cells/µL. CrAg screening at CD4 ≤100 cells/µL is cost-effective; however, the cost-effectiveness of screening patients with CD4 101–200 cells/µL requires evaluation. Methods: Using a decision analytic model with Botswana-specific cost and clinical estimates, we evaluated CrAg screening and treatment among individuals with CD4 counts of 101–200 cells/µL. We estimated the number of CM cases and deaths nationally and treatment costs without screening. For screening we modeled the number of CrAg tests performed, number of CrAg-positive patients identified, proportion started on pre-emptive fluconazole, CM cases and deaths. Screening and treatment costs were estimated and cost per death averted or disability-adjusted life year (DALY) saved compared with no screening. Results: Without screening, we estimated 142 CM cases and 85 deaths annually among individuals with CD4 101–200 cells/µL, with treatment costs of $368,982. With CrAg screening, an estimated 33,036 CrAg tests are performed, and 48 deaths avoided (1,017 DALYs saved). While CrAg screening costs an additional $155,601, overall treatment costs fall by $39,600 (preemptive and hospital-based CM treatment), yielding a net increase of $116,001. Compared to no screening, high coverage of CrAg screening and pre-emptive treatment for CrAg-positive individuals in this population avoids one death for $2440 and $114 per DALY saved. In sensitivity analyses assuming a higher proportion of antiretroviral therapy (ART)-naïve patients (75% versus 15%), cost per death averted was $1472; $69 per DALY saved. Conclusions: CrAg screening for individuals with CD4 101–200 cells/µL was estimated to have a modest impact, involve additional costs, and be less cost-effective than screening populations with CD4 counts ≤100 cells/µL. Additional CrAg screening costs must be considered against other health system priorities.
The genome sequence of the yellow-tail moth, Euproctis similis (Fuessly, 1775)
Authors: Boyes Douglas H. , Holland Peter W.H. ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: December 2021

We present a genome assembly from an individual male Euproctis similis (the yellow-tail; Arthropoda; Insecta; Lepidoptera; Lymantriidae). The genome sequence is 508 megabases in span. Over 99% of the assembly is scaffolded into 22 chromosomal pseudomolecules, with the Z sex chromosome assembled. The complete mitochondrial genome, 15.5 kb in length, was also assembled.
Combining Polyhedral Approaches and Stochastic Dual Dynamic Integer Programming for Solving the Uncapacitated Lot-Sizing Problem Under Uncertainty
Authors: Quezada Franco , Gicquel Céline , Kedad-Sidhoum Safia 
Published: December 2021

We study the uncapacitated lot-sizing problem with uncertain demand and costs. The problem is modeled as a multistage stochastic mixed-integer linear program in which the evolution of the uncertain parameters is represented by a scenario tree. To solve this problem, we propose a new extension of the stochastic dual dynamic integer programming algorithm (SDDiP). This extension aims at being more computationally efficient in the management of the expected cost-to-go functions involved in the model, in particular by reducing their number and by exploiting the current knowledge on the polyhedral structure of the stochastic uncapacitated lot-sizing problem. The algorithm is based on a partial decomposition of the problem into a set of stochastic subproblems, each one involving a subset of nodes forming a subtree of the initial scenario tree. We then introduce a cutting plane–generation procedure that iteratively strengthens the linear relaxation of these subproblems and enables the generation of an additional strengthened Benders’ cut, which improves the convergence of the method. We carry out extensive computational experiments on randomly generated large-size instances. Our numerical results show that the proposed algorithm significantly outperforms the SDDiP algorithm at providing good-quality solutions within the computation time limit. Summary of Contribution: This paper investigates a combinatorial optimization problem called the uncapacitated lot-sizing problem. This problem has been widely studied in the operations research literature as it appears as a core subproblem in many industrial production planning problems. We consider a stochastic extension in which the input parameters are subject to uncertainty and model the resulting stochastic optimization problem as a multistage stochastic integer program. To solve this stochastic problem, we propose a novel extension of the recently published stochastic dual dynamic integer programming (SDDiP) algorithm. The proposed extension relies on two main ideas: the use of a partial decomposition of the scenario tree and the exploitation of existing knowledge on the polyhedral structure of the stochastic uncapacitated lot-sizing problem. We provide the results of extensive computational experiments carried out on large-size randomly generated instances. These results show that the proposed extended algorithm significantly outperforms the SDDiP at providing good-quality solutions for the stochastic uncapacitated lot-sizing problem. Although the paper focuses on a basic lot-sizing problem, the proposed algorithmic framework may be useful to solve more complex practical production planning problems.
A Model of Search with Two Stages of Information Acquisition and Additive Learning
Authors: Gibbard Peter 
Published: December 2021

This paper presents a model of choice with two stages of information acquisition. In this model, the choice problem can be interpreted as a variant of a more general multiarmed bandit problem. We assume that information acquisition takes a simple “additive form”—the value of an alternative is the sum of two components, which the decision maker can learn by undertaking two stages of information acquisition. This assumption yields a model that is tractable for the purposes of structural estimation. One possible application of the model is to online purchasing on e-commerce sites. For a consumer on an e-commerce website, there are potentially two stages of information acquisition: the consumer can obtain information about an alternative from (i) browsing the search results page and (ii) clicking on the alternative. By way of contrast, in much of the literature on structural econometric models of online purchasing, there is typically only one stage of information acquisition. Our paper may, therefore, provide a more realistic theory for modeling search, at least for those types of search—such as online purchasing—that involve two stages of information acquisition. This paper was accepted by Manel Baucells, behavioral economics and decision analysis.
3D Printing and Product Assortment Strategy
Authors: Dong Lingxiu , Shi Duo , Zhang Fuqiang 
Published: December 2021

3D printing, as a production technology, differs from conventional technologies in three characteristics: design freedom—that is, it can handle certain product designs that conventional technologies cannot; quality distinction—that is, depending on the focal quality dimension, it can lead to a quality level superior or inferior to that of conventional technologies; and natural flexibility—that is, it is endowed with capacity flexibility without sacrificing operational efficiency. This paper investigates the joint impact of these characteristics when a firm selects conceptual designs to form its product assortment, taking into account the production-technology choices available for each design: 3D printing and two conventional technologies (dedicated and traditional flexible). Some designs can be processed by using any technology (generic), whereas others are specific to 3D printing (3D-specific). The firm selects designs to be handled by each technology and then invests accordingly in technology adoption, product development, capacity, and production. We characterize the structure of the optimal assortment based on the popularity of each design. Within the sets of generic designs and 3D-specific designs, respectively, the most popular designs should be included in the assortment; under a mild condition, the optimal assortment comprises the most popular ones among all the designs. Within the optimal assortment, 3D printing should handle the less popular generic designs than conventional technologies. We further demonstrate that the design freedom or improved quality associated with 3D printing may reduce the firm’s optimal product variety. In the absence of design freedom and quality distinction, natural flexibility by itself always enhances product variety; by contrast, traditional flexible technology may reduce product variety. Numerical study shows that 3D printing tends to be more valuable when popularities of the generic designs are distributed more evenly and when popularities of the 3D-specific designs are distributed less evenly. This paper was accepted by Vishal Gaur, operations management.
Novel home use of mechanical negative pressure wound therapy in diabetic foot ulcers
Authors: Lim Xuxin , Zhang Li , Hong Qiantai , Yong Enming , Neo Shufen , Chandrasekar Sadhana , Tan Glenn Wei Leong , Lo Zhiwen Joseph 
Published: December 2021

Objective: Mechanical negative pressure wound therapy is an ultraportable, light weight and disposable single-use device that has been shown to promote wound healing. This study evaluated home use of a mechanically powered negative pressure wound therapy (NPWT) in diabetic foot wounds. Methods: Patients underwent revascularisation and/or debridement or amputation before starting mechanical NPWT. Wound outcomes and images of the wounds were recorded at each follow-up visit by the wound nurse. Patients were followed up until wound closure or end of therapy. Results: A total of 12 patients (each with one wound) were included in the study. Of the 12 wounds, 33.3% (n=4) of wounds achieved primary wound closure while the remaining 66.6% (n=8) of wounds demonstrated a mean wound size reduction of 37.5±0.13%. Of the closed wounds, mean time to healing was 4.75±2.50 weeks. There was 100% limb salvage with no further debridement or amputations, and no 30-day unplanned readmissions. Mean length of hospital stay before starting home NPWT was 9.75±6.31 days. Mean number of NPWT changes was 8.33±2.67 sessions, while mean duration of therapy was 4.0±1.54 weeks. Mean cost of home NWPT therapy was US$1904±731 per patient. Conclusion: The home use of mechanically powered NPWT in diabetic foot wounds demonstrated excellent wound healing rates and 100% limb salvage, with no complications.
A dual pressure indicator, two-layer compression system for treatment of venous leg ulcers: a review
Authors: Tai Hong Qian , Chaen Lester Chong Rhan , Boey Johnson , Kime Sally , Rial Rodrigo , Montero Elena Conde , Atkin Leanne , Stansal Audrey , Isabelle Lazareth , Tickner Anthony , Vlad Lucian G , Lantis John , Hester Colboc , Galea Emilio 
Published: December 2021

Objective: Venous leg ulcers (VLUs) are considered the most frequent category of hard-to-heal limb ulcers. Although evidence-based care of VLUs suggests that compression therapy plays a pivotal role in the standard of care, patient adherence is considered low, with at least 33% non-compliance, either due to perceived problems from clinicians regarding their own competency in applying the bandages, or from the patient finding the wrapping bothersome. For many years, four-layer bandaging has been considered the ‘gold standard’, but application can be difficult and may also prove uncomfortable for patients. Accurate application may be facilitated by a stretch indicator which has been engineered to act as a surrogate for appropriate pressure application that can address the skill concern, while fewer layers can save clinicians' time and improve the quality of life of patients. Here, we review the literature supporting a two-layer system which combines elastic (long stretch) and inelastic (short stretch) components as well as both layers having graphic markers to define that the dressing has been applied at the proper tension. Method: An initial search was conducted on PubMed and then followed up by a manual search of Google Scholar to retrieve evidence of different levels, in order to evaluate the outcomes of use of the specific two-layer compression system with pressure indicators in the management of patients presenting with VLUs. Results: A total of four papers discussing the specific compression system in question were identified from 32 publications retrieved from PubMed, while a further six were retrieved from Google Scholar. These 10 publications were considered relevant to the two-layer system and were analysed for the outcomes of care, including wound healing, appropriate application, time-saving and better patient acceptance and adherence. Conclusion: Previous authors have demonstrated that two-layer systems are equivalent to four-layer systems. However, the ability to reproducibly apply appropriate compression has remained a question. The papers reviewed demonstrate that evidence suggests that the two-layer compression bandage system with indicators provides continuous, consistent and comfortable treatment that may be easier to apply with accurate pressure levels due to their indicator systems, and therefore, is a procedure that may increase patient adherence and acceptability to the wound therapy.
Successful Innovative Minimal Invasive Splenectomy in a Child with Combined Congenital Immunodeficiency and Acquired Pancytopenia Secondary to Hypersplenism
Authors: Anthony Favour Mfonobong , Govani Dhaval , Patel Rasila , Patel Ramnik 
Published: December 2021

Congenital combined immunodeficiency in association of acquired hypersplenism are uncommon lesions in pediatric patients and certainly poses several diagnostic and therapeutic challenges for successful and safe outcome of ideal treatment which has consequences of life long precautions. Herein, we report a case of combined immunodeficiency complicated by hypersplenism and pancytopenia in a 4-year-old female toddler who presented with hypogammaglobulinemia, low circulating B cells, and T cell lymphopenia, anemia and thrombocytopenia. The results of hematological investigations revealed pancytopenia with ongoing persistent anemia, thrombocytopenia and leukopenia. and bone marrow examination revealed adequate cellularity with normally functioning bone marrow and no circulating auto antibodies. A splenectomy using an innovative minimal invasive technique was performed for curative purposes. Any evidence of the recurrence of hypersplenism was not noted 30 months after the operation.
Surgery is the most frequently performed treatment for hypersplenism with pancytopenia and normal bone marrow and no circulating antibodies. Pre-operative and post splenectomy vaccination record and post splenectomy status cards provide additional precautions for rare but life-threatening post splenectomy complications.
Diabetic mice have retinal and choroidal blood flow deficits and electroretinogram deficits with impaired responses to hypercapnia
Authors: Muir Eric R. , Narayanan Divya , Chandra Saurav B. , Akimov Nikolay P. , Sohn Jeong-Hyeon , Meyer Evan , Rentería René C. , Duong Timothy Q. 
Published: December 2021

Purpose
The purpose of this study was to investigate neuronal and vascular functional deficits in the retina and their association in a diabetic mouse model. We measured electroretinography (ERG) responses and choroidal and retinal blood flow (ChBF, RBF) with magnetic resonance imaging (MRI) in healthy and diabetic mice under basal conditions and under hypercapnic challenge.

Methods
Ins2Akita diabetic (Diab, n = 8) and age-matched, wild-type C57BL/6J mice (Ctrl, n = 8) were studied under room air and moderate hypercapnia (5% CO2). Dark-adapted ERG a-wave, b-wave, and oscillatory potentials (OPs) were measured for a series of flashes. Regional ChBF and RBF under air and hypercapnia were measured using MRI in the same mice.

Results
Under room air, Diab mice had compromised ERG b-wave and OPs (e.g., b-wave amplitude was 422.2±10.7 μV in Diab vs. 600.1±13.9 μV in Ctrl, p < 0.001). Under hypercapnia, OPs and b-wave amplitudes were significantly reduced in Diab (OPs by 30.3±3.0% in Diab vs. -3.0±3.6% in Ctrl, b-wave by 17.9±1.4% in Diab vs. 1.3±0.5% in Ctrl). Both ChBF and RBF had significant differences in regional blood flow, with Diab mice having substantially lower blood flow in the nasal region (ChBF was 5.4±1.0 ml/g/min in Diab vs. 8.6±1.0 ml/g/min in Ctrl, RBF was 0.91±0.10 ml/g/min in Diab vs. 1.52±0.24 ml/g/min in Ctrl). Under hypercapnia, ChBF increased in both Ctrl and Diab without significant group difference (31±7% in Diab vs. 17±7% in Ctrl, p > 0.05), but an increase in RBF was not detected for either group.

Conclusions
Inner retinal neuronal function and both retinal and choroidal blood flow were impaired in Diab mice. Hypercapnia further compromised inner retinal neuronal function in diabetes, while the blood flow response was not affected, suggesting that the diabetic retina has difficulty adapting to metabolic challenges due to factors other than impaired blood flow regulation.
An investigation of the relationship between cyberbullying, cybervictimization and depression symptoms: A cross sectional study among university students in Qatar
Authors: Alrajeh Sara Mohamed , Hassan Huda Mohammed , Al-Ahmed Aisha Salim , Alsayed Hassan Diana 
Published: December 2021

Background
Cyberbullying is a modern form of bullying that could be practiced electronically or on the internet. It is related to different mental health issues such as depression, which can affect both the cyberbully and the victim. Although a few studies have been conducted regarding the prevalence of cyberbullying and cyber-victimization among the younger generation in Qatar, no studies have been conducted among young adults despite studies showing that they are also prone to cyberbullying.

Methods
This is a cross-sectional study to investigate the prevalence and the relationship between cyberbullying, cyber-victimization, and depression symptoms among Qatar University students. A self-administered close-ended electronic questionnaire was used to assess student’s cyberbullying/cyber-victimization behaviors and depression symptoms. The Revised Cyberbullying Inventory scale (RCBI-II) and Patient Health questionnaire-9 (PHQ-9) were utilized to measure involvement in cyberbullying and depression symptoms, respectively. A total of 836 students participated in the study. Pearson Chi-Square test and binary logistic regression were conducted to analyze the data.

Results
Results indicated the majority of students have been involved in cyberbullying as follows: 6.8% cyberbullies, 29.2% cybervictims, 35.8% cyberbully-victims, and 28.2% not involved in either. Approximately 50% of the students scored a ten or higher on the PHQ9 test indicating symptoms of depression. Moreover, significant associations were found between cyberbullying experiences and gender (p = 0.03), depression and gender (p = 0.046), and between cyberbullying experiences and depression (p<0.001).

Conclusion
Our findings indicate that among Qatar University students, cyberbullying and cyber-victimization are prevalent behaviors that could be associated with the high reported rates of depression symptoms.