bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sarcoplasmic and myofibrillar phosphoproteins profile of beef M. longissimus thoracis with different pHu at different days postmortem
Authors: Ijaz Muawuz , Li Xin , Zhang Dequan , Bai Yuqiang , Hou Chengli , Hussain Zubair , Zheng Xiaochun , Huang Caiyan 
Published: October 2021

AbstractBACKGROUNDThe abnormal ultimate pH (pHu) in postmortem muscles affect the meat quality and results in substantial economic losses. Dark, firm, and dry (DFD) meat linked with the higher postmortem pHu values and exhibited many quality issues such as dark color, tough texture and shorter shelf life. This research aimed to investigate the effect of protein phosphorylation on variations in beef pHu in order to explore the possible mechanisms underlying DFD meat formation.RESULTSGlycogen and lactate contents were higher, while L* and a* were lower in high pHu beef. Shear force was higher in intermediate pHu group. Global phosphorylation of sarcoplasmic proteins was higher in low pHu samples on day 1 and of myofibrillar proteins was higher in intermediate pHu meat on days 1 and 2 postmortem. Sarcoplasmic protein bands with different phosphorylation levels were identified as containing some glycometabolism and stress response proteins and phosphorylated myofibrillar protein bands were identified sarcomeric and metabolic proteins.CONCLUSIONSPhosphorylation of multiple proteins of glycolytic pathway and contractile machinery may play critical roles in development of DFD beef. © 2021 Society of Chemical Industry.
Rate of Development of Venous Thromboembolism in Lateral Skull Base Surgery
Authors: Anderson Brian P. , Sioshansi Pedrom C. , Conway Robert M. , Minutello Katrina , Bojrab Dennis I. , Hong Robert S. , Sargent Eric W. , Schutt Christopher A. , Bojrab Dennis I. , Zappia John J. , Babu Seilesh C. 
Published: October 2021

ObjectivesVenous thromboembolism (VTE) is a major cause of morbidity and mortality for surgical patients. This article aims to determine factors that may have contributed to the development of VTE in patients undergoing lateral skull base surgery, to assess the validity of the Caprini Risk Assessment Model (RAM) score in this subset of patients, and to determine the efficacy of mechanical DVT prophylaxis alone in preventing VTE.Study DesignRetrospective chart review.MethodsA retrospective chart review was conducted of patients who underwent skull base surgery for vestibular schwannoma, and the rate of VTE was assessed. Patient demographics, comorbidities, and treatment factors were examined to determine risk factors associated with the development of a postoperative thrombotic event. Caprini RAM scores were compared for patients who developed a VTE.ResultsAmong 197 patients, the rate of VTE formation was 3.5%. No individual risk factor independently contributed to the development of a thrombotic event. The mean Caprini RAM score was 4.06 in patients who did not develop a VTE and 5.14 in the patients that did develop a VTE (P = .005). The Caprini score was significant for the risk of VTE formation, with an odds ratio of 2.8 (P = .009, 95% CI = 1.3–6.2).ConclusionVenous thromboembolism rates are relatively low following lateral skull base surgery. While there is no individual risk factor associated with increased VTE risk, the Caprini RAM score appears to be a useful predictor of risk. The Caprini score may be useful in identifying high‐risk patients who may benefit from chemoprophylaxis for VTE prevention.Level of Evidence3 Laryngoscope, 132:662–667, 2022
Anisotropic Particles through Multilayer Assembly
Authors: Kozlovskaya Veronika , Kharlampieva Eugenia 
Published: October 2021

AbstractThe anisotropy in the shape of polymeric particles has been demonstrated to have many advantages over spherical particulates, including bio‐mimetic behavior, shaped‐directed flow, deformation, surface adhesion, targeting, motion, and permeability. The layer‐by‐layer (LbL) assembly is uniquely suited for synthesizing anisotropic particles as this method allows for simple and versatile replication of diverse colloid geometries with precise control over their chemical and physical properties. This review highlights recent progress in anisotropic particles of micrometer and nanometer sizes produced by a templated multilayer assembly of synthetic and biological macromolecules. Synthetic approaches to produce capsules and hydrogels utilizing anisotropic templates such as biological, polymeric, bulk hydrogel, inorganic colloids, and metal–organic framework crystals as sacrificial templates are overviewed. Structure‐property relationships controlled by the anisotropy in particle shape and surface are discussed and compared with their spherical counterparts. Advances and challenges in controlling particle properties through varying shape anisotropy and surface asymmetry are outlined. The perspective applications of anisotropic colloids in biomedicine, including programmed behavior in the blood and tissues as artificial cells, nano‐motors/sensors, and intelligent drug carriers are also discussed.
A computer aided drug discovery based discovery of lead‐like compounds against KDM5A for cancers using pharmacophore modeling and high‐throughput virtual screening
Authors: Tariq Asma , Rehman Hafiz Muzzammel , Mateen Rana Muhammad , Ali Moazzam , Mutahir Zeeshan , Afzal Muhammad Sohail , Sajjad Muhammad , Gul Roquyya , Saleem Mahjabeen 
Published: October 2021

AbstractKDM5A over‐expression mediates cancer cell proliferation and promotes resistance toward chemotherapy through epigenetic modifications. As its complete mechanism of action is still unknown, there is no KDM5A specific drug available at clinical level. In the current study, lead compounds for KDM5A were determined through pharmacophore modeling and high‐throughput virtual screening from Asinex libraries containing 0.5 million compounds. These virtual hits were further evaluated and filtered for ADMET properties. Finally, 726 compounds were used for docking analysis against KDM5A. On the basis of docking score, 10 top‐ranked compounds were selected and further evaluated for non‐central nervous system (CNS) and CNS drug‐like properties. Among these compounds, N‐{[(7‐Methyl‐4‐oxo‐1,2,3,4‐tetrahydrocyclopenta [c] chromen‐9‐yl) oxy]acetyl}‐l‐phenylalanine (G‐score: −11.363 kcal/mol) was estimated to exhibit non‐CNS properties while 2‐(3,4‐Dimethoxy‐phenyl)‐7‐methoxy‐chromen‐4‐one (G‐score: −7.977 kcal/mol) was evaluated as CNS compound. Docked complexes of both compounds were finally selected for molecular dynamic simulation to examine the stability. This study concluded that both these compounds can serve as lead compounds in the quest of finding therapeutic agents against KDM5A associated cancers.
Modelled changes in selected agroclimatic indices over the croplands of western Canada under the RCP8.5 scenario
Authors: Agyeman Richard Y. K. , Huo Fei , Li Zhenhua , Li Yanping 
Published: October 2021

AbstractTo assess the potential change in agroclimatic indices in western Canada, this study used a convection‐permitting Weather Research Forecasting (WRF) model to conduct simulations for the current climate (CTL, 2000–2015) and future climate under the RCP8.5 scenario based on a pseudo‐global‐warming (PGW) approach. Both CTL and PGW simulations were bias‐corrected to the GEM‐CaPA dataset using a multivariate quantile mapping method. An evaluation of the CTL simulation of daily maximum and minimum temperatures and precipitation during the growing season against the gridded observations has been performed, indicating good agreements in the spatial patterns of air temperature and precipitation in western Canada. The PGW − CTL differences in several selected agroclimatic indices were then examined. Due to rising temperatures, substantial increases in growing degree‐days (GDD) by 800–1,200° days and reductions in frost days by 10 to 20 days, favouring regional crop production, are found in southern Alberta and Saskatchewan. However, global warming also poses great risks to Canadian agriculture by modifying heat accumulations and water availability during the growing season. Plant heat stress will substantially increase by ∼50° days in southern Alberta and Saskatchewan, offsetting the positive effects caused by the reduction in frost days and increase in GDD. The southern Canadian Prairies will experience statistically significant increases in the number of dry days and precipitation deficit, suggesting an exacerbation of water stress on the Canadian Prairies by global warming.
Goal‐striving stress and repeated measures of adiposity in the Jackson heart study
Authors: Cain‐Shields Loretta , Glover LáShauntá , Joseph Joshua J. , Bertoni Alain G. , Sims Mario 
Published: October 2021

AbstractPsychosocial stressors are determinants of increases in adiposity. Both psychosocial stressors and adiposity are higher among African Americans (AAs). Therefore, clarifying the stress‐obesity link in AAs is important. The stress associated with goal striving is particularly relevant to AAs because opportunity for upward mobility is not always equal. Goal‐striving stress (GSS) has not been assessed with adiposity, a potential result of GSS. Therefore, the objective of this study was to determine whether GSS would be associated with repeated measures of adiposity [body mass index (BMI), waist circumference (WC), waist‐to‐height ratio (WHR)] in AAs. Linear mixed models were used to assess the relationship between GSS with repeated measures of adiposity across three exam periods among 2902 AAs, and sex was assessed as a moderator. Models were adjusted for demographics, health behaviours, morbidities, and daily discrimination. GSS was positively associated with repeated measures of adiposity in women but not men: WC [estimate (standard error) p‐value] [0.003 (0.001) p < 0.01] and WHR [0.003 (0.0007) p < 0.01]. This suggests that high stress due to goal striving may contribute to greater increases in adiposity in AA women over time. Community‐based interventions should continue to consider focused support group models as viable options for goal‐striving related stress reduction.
General helicity formalism for two-hadron production in e+e− annihilation within a TMD approach
Authors: D’Alesio Umberto , Murgia Francesco , Zaccheddu Marco 
Published: October 2021

Abstract
We present the complete leading-order results for the azimuthal dependences and polarization observables in e+e−→ h1h2 + X processes, where the two hadrons are produced almost back-to-back, within a transverse momentum dependent (TMD) factorization scheme. We consider spinless (or unpolarized) and spin-1/2 hadron production and give the full set of the corresponding quark and gluon TMD fragmentation functions (TMD-FFs). By adopting the helicity formalism, which allows for a more direct probabilistic interpretation, single- and double-polarization cases are discussed in detail. Simplified expressions, useful for phenomenological analyses, are obtained by assuming a factorized Gaussian-like dependence on intrinsic transverse momenta for the TMD-FFs.
AdS (super)projectors in three dimensions and partial masslessness
Authors: Hutchings Daniel , Kuzenko Sergei M. , Ponds Michael 
Published: October 2021

Abstract
We derive the transverse projection operators for fields with arbitrary integer and half-integer spin on three-dimensional anti-de Sitter space, AdS3. The projectors are constructed in terms of the quadratic Casimir operators of the isometry group SO(2, 2) of AdS3. Their poles are demonstrated to correspond to (partially) massless fields. As an application, we make use of the projectors to recast the conformal and topologically massive higher-spin actions in AdS3 into a manifestly gauge-invariant and factorised form. We also propose operators which isolate the component of a field that is transverse and carries a definite helicity. Such fields correspond to irreducible representations of SO(2, 2). Our results are then extended to the case of $$ \mathcal{N} $$
N
= 1 AdS3 supersymmetry.
The mucosal immune system and IgA nephropathy
Authors: Gesualdo Loreto , Di Leo Vincenzo , Coppo Rosanna 
Published: October 2021

Abstract
The precise pathogenesis of immunoglobulin A nephropathy (IgAN) is still not clearly established but emerging evidence confirms a pivotal role for mucosal immunity. This review focuses on the key role of mucosa-associated lymphoid tissue (MALT) in promoting the onset of the disease, underlying the relationship among microbiota, genetic factors, food antigen, infections, and mucosal immune response. Finally, we evaluate potential therapies targeting microbes and mucosa hyperresponsiveness in IgAN patients.
Root and shoot growth of spring wheat (Triticum aestivum L.) are differently affected by increasing subsoil biopore density when grown under different subsoil moisture
Authors: Koch Mirjam , Boselli Roberta , Hasler Mario , Zörb Christian , Athmann Miriam , Kautz Timo 
Published: October 2021

AbstractA column experiment with five different pore densities (0, 1, 2, 3, and 4 pores column−1) and two varying moisture regimes (comparatively dry and comparatively moist regime) in the subsoil part of the columns was established. In each pore, Lumbricus terrestris was introduced for 28 days before sowing wheat plants. After 40 days of plant growth, watering was stopped to induce progressive topsoil drying. Parameters describing the shoot hydration, mineral uptake, and aboveground biomass were quantified. Root biomass and root length densities (RLD) were measured separately for six soil layers. Under dry subsoil conditions, plants grown under increasing biopore density showed an increase of the RLD and an improved shoot hydration but the aboveground biomass was unaffected. Since RLD but not root biomass was enhanced, it is assumed that roots were able to explore a larger volume of soil with the same amount of root biomass. Thereby, subsoil water likely was used more efficiently leading to an improved hydration. Under moist subsoil conditions, plants grown with increasing biopore density revealed enhanced shoot biomasses and nutrient uptake while the belowground biomass was unaffected. The improved nutrient uptake can be ascribed to, first, the higher subsoil water availability favoring mass flow driven nutrient uptake, and second, to direct and indirect effects of earthworms on the availability of soil nutrients. It is concluded that high biopore abundancies have the potential to improve not only the belowground but also the aboveground biomass. This, however, largely depends on subsoil moisture.
Direct numerical simulation of the scouring of a brittle streambed in a turbulent channel flow
Authors: Dalla Barba Federico , Picano Francesco 
Published: October 2021

AbstractThe natural processes involved in the scouring of submerged sediments are crucially relevant in geomorphology along with environmental, fluvial, and oceanographic engineering. Despite their relevance, the phenomena involved are far from being completely understood, in particular for what concerns cohesive or stony substrates with brittle bulk mechanical properties. In this frame, we address the investigation of the mechanisms that govern the scouring and pattern formation on an initially flattened bed of homogenous and brittle material in a turbulent channel flow, employing direct numerical simulation. The problem is numerically tackled in the frame of peridynamic theory, which has intrinsic capabilities of reliably reproducing crack formation, coupled with the Navier–Stokes equations by the immersed boundary method. The numerical approach is reported in detail here and in the references, where extensive and fully coupled benchmarks are provided. The present paper focuses on the role of turbulence in promoting the brittle fragmentation of a solid, brittle streambed. A detailed characterization of the bedforms that originate on the brittle substrate is provided, alongside an analysis of the correlation between bed shape and the turbulent structures of the flow. We find that turbulent fluctuations locally increase the intensity of the wall-stresses producing localized damages. The accumulation of damage drives the scouring of the solid bed via a turbulence-driven fatigue mechanism. The formation, propagation, and coalescence of scouring structures are observed. In turn, these affect both the small- and large-scale structures of the turbulent flow, producing an enhancement of turbulence intensity and wall-stresses. At the small length scales, this phenomenology is put in relation to the formation of vortical cells that persist over the peaks of the channel bed. Similarly, large-scale irregularities are found to promote the formation of stationary turbulent stripes and large-scale vortices that enhance the widening and deepening of scour holes. As a result, we observe a quadratic increment of the volumetric erosion rate of the streambed, as well as a widening of the probability density of high-intensity wall stress on the channel bed.
A dynamic Markov model to assess the cost-effectiveness of the Kidney Team at Home intervention in The Netherlands
Authors: Redeker Steef , Ismail Sohal , Eeren Hester V. , Massey Emma K. , Weimar Willem , Oppe Mark , Busschbach Jan ,   the Kidney Team at Home consortium
Published: October 2021

Abstract
Objectives
The Kidney Team at Home program is an educational intervention aimed at patients with chronic kidney disease to assist them in their choice for kidney replacement therapy. Previous studies have shown that the intervention results in an increase in knowledge and communication on kidney replacement therapy, and eventually in an increase in the number of living donor kidney transplantations. The study assesses the cost-effectiveness of the intervention compared to standard care.

Methods
A dynamic probabilistic Markov model was used to estimate the monetary and health benefits of the intervention in The Netherlands over 10 years. Data on costs and health-related quality of life were derived from the literature. Transition probabilities, prevalence, and incidence rates were calculated using a large national database. An optimistic and a pessimistic implementation scenario were compared to a base case scenario with standard care.

Results
In both the optimistic and pessimistic scenario, the intervention is cost-effective and dominant compared to standard care: savings were €108,681,985 and €51,770,060 and the benefits were 1382 and 695 QALYs, respectively.

Conclusions
The superior cost-effectiveness of the intervention is caused by the superior health effects and the reduction of costs associated with transplantation, and the relatively small incremental costs of the intervention. The favorable findings of this implementation project resulted in national uptake of the intervention in The Netherlands as of 2021. This is the first time a psychosocial intervention has been implemented as part of standard care in a kidney replacement therapy program worldwide.
The impact of Clean Spark Spread expectations on storage hydropower generation
Authors: Condemi Claudia , Mastroeni Loretta , Vellucci Pierluigi 
Published: October 2021

AbstractStorage hydropower generation plays a crucial role in the electric power system and energy transition because it is the most widespread power generation with low greenhouse gas emissions and, moreover, it is relatively cheap to ramp up and down. As a result, it provides flexibility to the grid and helps mitigate the short-term production uncertainty that affects most green energy technologies. However, using water in reservoirs represents an opportunity cost, which is related to the evolution of plant production capacity and production profitability. As the latter is related to a wide range of types of variables, in order to incorporate it in a large-scale prediction model it is important to select the variables that impact most on storage hydropower generation. In this paper, we investigate the impact of the variables influencing the choices of price maker producers, and, in particular we study the impact of Clean Spark Spread expectations on storage hydroelectric generation. In this connection, using entropy and machine learning tools, we present a method for embedding this expectations in a model to predict storage hydropower generation, showing that, for some time horizon, expectations on CSS have a greater impact than expectations on power prices. It is shown that, if the right mix of power price and CSS expectations is considered, the prediction error of the model is drastically reduced. This implies that it is important to incorporate CSS expectations into the storage hydropower model.
Breath figure templated self-assembly of surface-acylated cellulose nanowhiskers confined as honeycomb films
Authors: Liu Huan , Pang Bo , Zhang Kai 
Published: October 2021

AbstractThe self-assembly of cellulose nanowhiskers (CNWs) in confined geometries provides a powerful method for the fabrication of novel structures. Herein, ordered honeycomb microporous films were first prepared with surface-acylated CNWs (CNWs-SU) through the breath figure method. Resulting films showed highly porous order over large regions and the iridescent color was only displayed by their rims, which is different from traditional dish-cast CNW films showing the iridescent color over the whole area. This is mainly due to the condensation of water droplets forming three-dimensional (3D) geometry, which forced CNWs-SU to self-assemble into cholesteric architectures in confined geometry and resulted in the iridescent color of the rims after drying. The mechanism was further studied by investigating the critical influencing factors, primarily the concentration of CNW-SU suspensions, the relative humidity of the atmosphere and the surface-attached moieties. In particular, CNW-SU suspensions with a concentration of 3 mg/mL at the relative humidity of 75% preferentially formed honeycomb films with uniform pores. Too low or too high concentrations of CNW-SU suspensions or relative humidity are not preferable for uniform porous films. CNWs-SU with further immobilized octadecane or fluoroalkyl groups on their surface strongly affected the formation of uniform porous films because of higher hydrophobicity and accompanying inhomogeneous condensation of water droplets. This work provides a novel method to study the interactions of CNWs beyond the planar geometry and the formation of uniform porous films solely with CNWs with structural colors open up interesting possibilities for broad application in photonic nanomaterials.
Graphic abstract