bluuebunny/crossref_metadata_2025_split huggingface dataset:
Site‐Selective Occupancy of Eu2+ toward High Luminescence Switching Contrast in BaMgSiO4‐Based Photochromic Materials
Authors: Zhu Yan , Sun Haiqin , Jia Qiannan , Guan Lili , Peng Dengfeng , Zhang Qiwei , Hao Xihong 
Published: January 2021

AbstractLuminescent inorganic photochromics have great potential applications in 3D optical memory due to their excellent thermal stability and chemical resistance. Nevertheless, constructing inorganic photochromics with a high luminescence switching contrast remains challenging for optical information storage. Understanding inherent relationships between microenvironment changes, photophysical material properties, and rational control of their luminescence properties are crucial to address these issues. This paper proposes an effective strategy to significantly improve the luminescence switching contrast by more than 300% by site‐selective occupancy engineering on BaMgSiO4:Eu2+ photochromic materials. An effective energy transfer process is established between luminescent and photochromic units, which may provide new insights for designing high‐performance optical storage systems. The fabricated flexible films exhibit excellent waterproof, flexibility, and stretchability characteristics, accompanied by reversible color switching and larger color contrast. Optical data storage can be not only visually encoded and decoded on the flexible films by 405 and 532 nm LED excitation, respectively. Writing, erasing, and reading strategies for flexible films are particularly suitable for complex application environments in optical storage and rewritable flexible devices.
Programmed Molecular Assembly of Abrupt Crystalline Organic/Organic Heterointerfaces Yielding Metal‐Organic Framework Diodes with Large On‐Off Ratios
Authors: Chandresh Abhinav , Liu Xiaojing , Wöll Christof , Heinke Lars 
Published: January 2021

AbstractStructurally well‐defined, crystalline organic/organic heterojunctions between C60‐ and anthracene‐based semiconductors are realized via layer‐by‐layer deposition of metal‐organic framework, MOF, thin films. As demonstrated by X‐ray diffraction, perfect epitaxy is achieved by adjusting the lattice constants of the two different MOFs. Deposition of top electrodes allows to fabricate p–n as well as n–p devices. Measurements of the electrical properties reveal the presence of high‐performance diodes, with a current on/off ratio of up to 6 orders of magnitude and an ideality factor close to unity. The crystalline nature of the abrupt organic/organic heterojunction provides the basis for a rational, simulation‐based optimization and tailoring of such organic semiconductor interfaces.
Metal−Organic Frameworks for Liquid Phase Applications
Authors: Nalaparaju Anjaiah , Jiang Jianwen 
Published: January 2021

AbstractIn the last two decades, metal−organic frameworks (MOFs) have attracted overwhelming attention. With readily tunable structures and functionalities, MOFs offer an unprecedentedly vast degree of design flexibility from enormous number of inorganic and organic building blocks or via postsynthetic modification to produce functional nanoporous materials. A large extent of experimental and computational studies of MOFs have been focused on gas phase applications, particularly the storage of low‐carbon footprint energy carriers and the separation of CO2‐containing gas mixtures. With progressive success in the synthesis of water‐ and solvent‐resistant MOFs over the past several years, the increasingly active exploration of MOFs has been witnessed for widespread liquid phase applications such as liquid fuel purification, aromatics separation, water treatment, solvent recovery, chemical sensing, chiral separation, drug delivery, biomolecule encapsulation and separation. At this juncture, the recent experimental and computational studies are summarized herein for these multifaceted liquid phase applications to demonstrate the rapid advance in this burgeoning field. The challenges and opportunities moving from laboratory scale towards practical applications are discussed.
Spider Origami: Folding Principle of Jumping Spider Leg Joints for Bioinspired Fluidic Actuators
Authors: Göttler Chantal , Elflein Karin , Siegwart Roland , Sitti Metin 
Published: January 2021

AbstractJumping spiders (Phidippus regius) are known for their ability to traverse various terrains and have targeted jumps within the fraction of a second to catch flying preys. Different from humans and insects, spiders use muscles to flex their legs, and hydraulic actuation for extension. By pressurizing their inner body fluid, they can achieve fast leg extensions for running and jumping. Here, the working principle of the articular membrane covering the spider leg joint pit is investigated. This membrane is highly involved in walking, grasping, and jumping motions. Hardness and stiffness of the articular membrane is studied using nanoindentation tests and preparation methods for scanning electron microscopy and histology are developed to give detailed information about the inner and outer structure of the leg joint and its membrane. Inspired by the stroller umbrella‐like folding mechanism of the articular membrane, a robust thermoplastic polyurethane‐based rotary semifluidic actuator is demonstrated, which shows increased durability, achieves working angles over 120°, produces high torques which allows lifts over 100 times of its own weight and jumping abilities. The developed actuator can be used for future grasping tasks, safe human–robot interactions and multilocomotion ground robot applications, and it can shed light into spider locomotion‐related questions.
Evaluation of maize varieties for mechanical grain harvesting in mid‐latitude region, China
Authors: Zhang Zhentao , Ming Bo , Liang Hongwei , Huang Zhaofu , Wang Keru , Yang Xiaoguang , Wang Zhigang , Xie Ruizhi , Hou Peng , Zhao Ruixia , Li Shaokun 
Published: January 2021

AbstractHow to allocate heat resources during yield formation and grains drying in the field to ensure food security while reducing the grain moisture content (GMC) is an important issue in maize (Zea mays L.) production in China. In this study, we established three production scenarios (traditional production (TPS, GMC > 30% at harvest), mid‐moisture grain harvest (MMHS, GMC ≤ 25% at harvest), and low‐moisture grain harvest (LMHS, GMC ≤ 20% at harvest)). Five varieties (DMY1, FK139, DK159, XY335, and JK968) were selected as model varieties to establish a grain drying prediction model, and the model prediction accuracy was good (RMSE = 2.96–4.04%, R2 = .408–.733). Results revealed that the production loss of the LMHS was 23.7% compared to the TPS, while the MMHS had a production loss of 6.5%. By replacing new varieties with high yield potential and fast grain drying rate, even small production increases can be achieved in MMHS. By adjusting the layout, it was possible to achieve 25% GMC in Inner Mongolia, which can promote the mechanical grain harvesting. However, the conditions for further reducing GMC (20%) at harvest are not yet available, and this requires more detailed future research.
SARS‐CoV‐2 pandemic in the Brazilian community of rare diseases: A patient reported survey
Authors: Schwartz Ida Vanessa Doederlein , Randon Dévora Natalia , Monsores Natan , Moura de Souza Carolina Fischinger , Horovitz Dafne Dain Gandelman , Wilke Matheus Vernet Machado Bressan , Brunoni Decio 
Published: January 2021

AbstractThe COVID‐19 pandemic has led to a reorganization of health systems to prioritize the fight against the virus. The adoption of social distancing interfered with the flow of existing policies, and may thus negatively affect the most vulnerable groups, such as the rare disease community. Aimming at characterizing the perception of the impact of COVID‐19 on the health care of the Brazilian rare disease community, an online questionnaire addressed to patients with rare diseases and their caregivers was disseminated in the Brazilian territory between June 1st to July 5th, 2020. The questions dealt with the sanitary measures adopted; access to medical services; and mental suffering during the pandemic. The survey was answered by 1,466 participants (<18 yo = 53.3%) representing 192 rare diseases. Regarding physical distancing, 1,372 (93.6%) participants did not leave their residence, or did so only when essential; 1,321 (90.1%) always wore masks when leaving home. 1,042 (71.1%) and 995 (67.9%) participants, respectively, referred medical genetics appointments and rehabilitation therapies were postponed/canceled. Telemedicine was experienced by 1,026 (70%), and 68.3% agreed this is a good strategy for health care. Patients with Inborn Errors of Metabolism (IEM, n = 624, 42.5%) appear to have more access to information and ability to overcome difficulties, and feel less threatened, lonely and depressed than the non‐IEM group (p < .05). There was an increment of the rare disease patients' vulnerability in the pandemic scenario. The cooperation of patients/caregivers along with adaptation of the health system is crucial and may be so even post‐pandemic.
Mechanical properties and morphology of modified celluloid foams
Authors: Massart Morgane , Dubois Charles , Boileau Marc 
Published: January 2021

AbstractCelluloid is a highly flammable plastic made of nitrocellulose and camphor, as a plasticizer, and it has recently received interest as a material for making combustible containers. For this particular application, the inherent combustion properties of celluloid are enhanced by foaming the material. This work evaluates novel celluloid‐like formulations in which camphor is replaced by alternative plasticizers and alternative nucleating agents are also evaluated to further improve the properties of the foams. The effects of these new components on the tensile properties and on the morphology of the combustible plastic are investigated for three plasticizers and for two nucleating agents. Results show that some plasticizers bring mechanical properties exceeding those of regular celluloid, an improvement of Young modulus and tensile stresses by more than 100% was observed. The effect of the nucleating agent on the foamed material's microstructure is also clearly observed, size and number of cells are correlated to the nature and the concentration of the nucleating agent.
IdentifyingDNA‐binding proteins based on multi‐features andLASSOfeature selection
Authors: Zhang Shengli , Zhu Fu , Yu Qianhao , Zhu Xiaoyue 
Published: January 2021

AbstractDNA‐binding proteins perform an indispensable function in the maintenance and processing of genetic information and are inefficiently identified by traditional experimental methods due to their huge quantities. On the contrary, machine learning methods as an emerging technique demonstrate satisfactory speed and accuracy when used to study these molecules. This work focuses on extracting four different features from primary and secondary sequence features: Reduced sequence and index‐vectors (RS), Pseudo‐amino acid components (PseAACS), Position‐specific scoring matrix‐Auto Cross Covariance Transform (PSSM‐ACCT), and Position‐specific scoring matrix‐Discrete Wavelet Transform (PSSM‐DWT). Using the LASSO dimension reduction method, we experiment on the combination of feature submodels to obtain the optimized number of top rank features. These features are respectively input into the training Ensemble subspace discriminant, Ensemble bagged tree and KNN to predict the DNA‐binding proteins. Three different datasets, PDB594, PDB1075, and PDB186, are adopted to evaluate the performance of the as‐proposed approach in this work. The PDB1075 and PDB594 datasets are adopted for the five‐fold cross‐validation, and the PDB186 is used for the independent experiment. In the five‐fold cross‐validation, both the PDB1075 and PDB594 show extremely high accuracy, reaching 86.98% and 88.9% by Ensemble subspace discriminant, respectively. The accuracy of independent experiment by multi‐classifiers voting is 83.33%, which suggests that the methodology proposed in this work is capable of predicting DNA‐binding proteins effectively.
Structural model for analysis of key performance indicators for sustainable manufacturer–supplier collaboration: A grey‐decision‐making trial and evaluation laboratory‐based approach
Authors: Govindan Kannan , Aditi  , Dhingra Darbari Jyoti , Kaul Arshia , Jha PC 
Published: January 2021

AbstractWith growing competition in the market and dire need for sustainability, it has become imperative for companies to build long‐term relationship with their supply chain partners through sustainable collaboration. Among these, the supplier–manufacturer relationship is crucial for improved organizational, business and sustainable performance. Sustainable collaboration with suppliers involves crucial decision‐making processes such as continuous supplier monitoring and supplier development. Hence, a critical challenge that a company faces is to identify the key performance indicators (KPIs) for assessing the performance of a supplier for sustainable collaboration. In this regard, this study focuses on identification of KPIs for an Indian home appliance company through exhaustive discussions involving multiple decision‐makers. Further, a grey‐based decision‐making trial and evaluation laboratory (DEMATEL) model is proposed in the study for analysing the importance levels among the fifteen KPIs based on multiple stakeholder perspectives. The results of the grey structural model indicate seven KPIs as influencing KPIs and eight KPIs as influenced KPIs. The KPI ‘Information disclosure’ has been identified as the most influential KPI for the evaluation of suppliers for sustainable collaboration. The implications drawn from the result analysis model can provide meaningful insights to managers for identifying strategies towards strengthening the supplier–manufacturer relationship and achieving organizational and market competence.
BAALC‐AS1/G3BP2/c‐Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma
Authors: Zhang Hongyue , Wang Yan , Zhang Weimin , Wu Qingnan , Fan Jiawen , Zhan Qimin 
Published: January 2021

AbstractBackgroundLong non‐coding RNAs (lncRNAs) have been found to be involved in the development of many cancers. In this study, we aimed to identify the molecular mechanisms of lncRNA BAALC antisense RNA 1 (BAALC‐AS1) in regulating the malignancy of esophageal squamous cell carcinoma (ESCC).MethodsThe expression of BAALC‐AS1 in cancer patients was analyzed using a tissue microarray. The protein and RNA levels of BAALC‐AS1 were determined by Western blotting analysis and quantitative reverse transcription‐PCR (RT‐qPCR), respectively. The cell proliferation was determined by cell viability assays, bromodeoxyuridine incorporation, and flow cytometry. The relationships among BAALC‐AS1, RasGAPSH3 domain‐binding protein 2 (G3BP2), and c‐Myc were determined using RNA immunoprecipitation, RNA pull‐down assays, and luciferase assays.ResultsThe expression of BAALC‐AS1 was highly up‐regulated and associated with malignant phenotypes in ESCC tissues and cell lines. In vivo and in vitro assays showed that BAALC‐AS1 promoted ESCC cell proliferation, migration, and invasion. BAALC‐AS1 directly interacted with G3BP2, and thereby inhibited the degradation of c‐Myc RNA 3'‐UTR by G3BP2, thus leading to the accumulation of c‐Myc expression. Additionally, c‐Myc acted as a transcription factor that can induce the expression of BAALC‐AS1 by directly binding to its promoter region.ConclusionsBAALC‐AS1/G3BP2/c‐Myc feedback loop plays a critical role in the development of ESCC, which might provide a novel therapeutic target and facilitate the development of new therapeutic strategies for the treatment of ESCC.
The efficacy and safety of definitive concurrent chemoradiotherapy for non‐operable esophageal cancer
Authors: Dreyfuss Alexandra D. , Barsky Andrew R. , Wileyto E. Paul , Eads Jennifer R. , Kucharczuk John C. , Williams Noel N. , Karasic Thomas B. , Metz James M. , Ben‐Josef Edgar , Plastaras John P. , Wojcieszynski Andrzej P. 
Published: January 2021

AbstractObjectiveTo report outcomes and toxicity in patients who received definitive concurrent chemoradiation (DCCRT) for non‐operable esophageal cancer (EC) in the modern era, and to identify markers of overall and disease‐free survival (OS/DFS).MethodsWe conducted a retrospective cohort study of patients with unresectable EC who received DCCRT at our institution between 1/2008 and 1/2019. Descriptive statistics were used to report disease‐control outcomes and CTCAE v4.0–5.0 toxicities. Univariable and multivariable Cox regression, and stepwise regression were used to identify associations with survival.ResultsAt a median follow‐up of 19.5 months, 130 patients with adenocarcinoma (AC) (62%) or squamous cell carcinoma (SCC) (38%) were evaluable (Stage II‐III: 92%). Patients received carboplatin/paclitaxel (75%) or fluorouracil‐based (25%) concurrent chemotherapy. Median total RT dose was 50.4 Gy (range, 44.7–71.4 Gy) delivered in 28 fractions (24–35). Locoregional and distant recurrence occurred in 30% and 35% of AC, and 24% and 33% of SCC, respectively. Median OS and DFS were 22.9 and 10.7 months in AC, and 25.7 and 20.2 months in SCC, respectively. On stepwise regression, tumor stage, feeding tube during DCCRT, and change in primary tumor PET/CT SUVmax were significantly associated with OS and DFS. Most severe toxicities were acute grade 4 hematologic cytopenia (6%) and radiation dermatitis (1%). Most common acute grade 3 toxicities were hematologic cytopenia (35%), dysphagia (23%), and anorexia (19%).ConclusionsTreatment of non‐operable EC with DCCRT has acceptable toxicity and can provide multi‐year disease control for some patients, even in AC. Continued follow‐up and investigation in large studies would be useful.
Venous congestion assessment using point‐of‐care Doppler ultrasound: Welcome to the future of volume status assessment
Authors: Koratala Abhilash 
Published: January 2021

AbstractWith evolution of clinician‐performed bedside ultrasonography, noninvasive markers of venous congestion such as hepatic, portal, and intrarenal venous Doppler waveforms are gaining importance as an adjunct to volume status assessment. The intent of this clinical image is to illustrate the classic sonographic stigmata of severe venous congestion, associated with worse prognosis.
Measuring the permeabilities of binary gas mixtures with a novel time‐lag technique
Authors: He Zhou , Goh Kheng Lim , Feng Xianshe , Wang Kean 
Published: January 2021

AbstractMeasuring permeation properties of gas mixtures is an important but challenging issue. This work reports on a novel time‐lag technique by selectively depositing (ie, desublimation) one of the gas components in a binary mixture at the downstream side using a liquid nitrogen cold trap, thereby allowing for determination of the permeation properties of both permeating components from the pressure response in the permeate chamber. The measurement technique was demonstrated for the permeation of several binary gas mixtures (H2/CO2, and He/CO2with various compositions) through a carbon molecular sieve membrane. It was found that the true permeation properties of a binary mixture can be significantly different from the ideal values based on the permeation of pure gas components. This method is time and cost efficient and works well for binary gas mixtures where the difference in the boiling points of the gas components is sufficiently large so that one of the components in the permeate can be selectively desublimated at the permeate side.
N‐Terminal Protein Labeling with N‐Hydroxysuccinimide Esters and Microscale Thermophoresis Measurements of Protein‐Protein Interactions Using Labeled Protein
Authors: Jiang Hanjie , Cole Philip A. 
Published: January 2021

AbstractProtein labeling strategies have been explored for decades to study protein structure, function, and regulation. Fluorescent labeling of a protein enables the study of protein‐protein interactions through biophysical methods such as microscale thermophoresis (MST). MST measures the directed motion of a fluorescently labeled protein in response to microscopic temperature gradients, and the protein's thermal mobility can be used to determine binding affinity. However, the stoichiometry and site specificity of fluorescent labeling are hard to control, and heterogeneous labeling can generate inaccuracies in binding measurements. Here, we describe an easy‐to‐apply protocol for high‐stoichiometric, site‐specific labeling of a protein at its N‐terminus with N‐hydroxysuccinimide (NHS) esters as a means to measure protein‐protein interaction affinity by MST. This protocol includes guidelines for NHS ester labeling, fluorescent‐labeled protein purification, and MST measurement using a labeled protein. As an example of the entire workflow, we additionally provide a protocol for labeling a ubiquitin E3 enzyme and testing ubiquitin E2‐E3 enzyme binding affinity. These methods are highly adaptable and can be extended for protein interaction studies in various biological and biochemical circumstances. © 2021 Wiley Periodicals LLC.This article was corrected on 18 July 2022. See the end of the full text for details.Basic Protocol 1: Labeling a protein of interest at its N‐terminus with NHS esters through stepwise reactionAlternate Protocol: Labeling a protein of interest at its N‐terminus with NHS esters through a one‐pot reactionBasic Protocol 2: Purifying the N‐terminal fluorescent‐labeled protein and determining its concentration and labeling efficiencyBasic Protocol 3: Using MST to determine the binding affinity of an N‐terminal fluorescent‐labeled protein to a binding partner.Basic Protocol 4: NHS ester labeling of ubiquitin E3 ligase WWP2 and measurement of the binding affinity between WWP2 and an E2 conjugating enzyme by the MST binding assay
Membrane engineering of cell membrane biomimetic nanoparticles for nanoscale therapeutics
Authors: Zhang Minghai , Cheng Shanshan , Jin Yue , Zhang Nan , Wang Yu 
Published: January 2021

AbstractIn recent years, cell membrane camouflaging technology has emerged as an important strategy of nanomedicine, and the modification on the membranes is also a promising approach to enhance the properties of the nanoparticles, such as cancer targeting, immune evasion, and phototherapy sensitivity. Indeed, diversified approaches have been exploited to re‐engineer the membranes of nanoparticles in several studies. In this review, first we discuss direct modification strategy of cell membrane camouflaged nanoparticles (CM‐NP) via noncovalent, covalent, and enzyme‐involved methods. Second, we explore how the membranes of CM‐NPs can be re‐engineered at the cellular level using strategies such as genetic engineering and membranes fusion. Due to the innate biological properties and excellent biocompatibility, the functionalized cell membrane‐camouflaged nanoparticles have been widely applied in the fields of drug delivery, imaging, detoxification, detection, and photoactivatable therapy.