bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changing the Home Visiting Research Paradigm: Models’ Perspectives on Behavioral Pathways and Intervention Techniques to Promote Good Birth Outcomes
Authors: Duggan Anne K , Bower Kelly M , Zagaja Ciara , O'Neill Kay , Daro Deborah , Harding Kathryn , Ingalls Allison , Kemner Allison , Marchesseault Crista , Thorland William 
Published: January 2021

Abstract
Background: The US is scaling up evidence-based home visiting to promote health equity in expectant families and families with young children. Persistently small average effects for full models argue for a shift in the research paradigm to understand what interventions within full models work best, for which families, in which contexts, why, and how. Historically, the complexity and proprietary nature of most evidence-based models have been barriers to such research. To address this, stakeholders are building the Precision Paradigm, a common framework and language to define and test interventions and their mediators and moderators. This observational study applied portions of the Paradigm to describe models' intended behavioral pathways to good birth outcomes and their stance on home visitors' use of specific intervention techniques to promote families' progress along intended pathways.Methods: Five of the six eligible evidence-based models participated. Model representatives independently completed three structured surveys focused on 41 intended behavioral pathways and 23 behavior change technique categories. Survey data were used to describe: the number and nature of models' intended behavioral pathways to good birth outcomes; the behavior change techniques they required or recommended home visitors to use; the relative emphasis given to required/recommended techniques; the compatibility of other techniques with their model; and the consistency of their stance on techniques across intended pathways.Results: Models defined 31.6 intended pathways on average but varied in their number of intended pathways (range 16-41) and the nature of such pathways. They varied in the number of technique categories they required (mean 3.2, range 0-8.9) or recommended (mean 10.6, range 1.5-20.0) that home visitors use. That said, all models rated nearly all technique categories as at least compatible with their model, even if not explicitly required or recommended. Within intended pathways, models varied in the relative emphasis to give to specific techniques. Models varied in the consistency of their requirements and recommendations for using specific techniques across intended pathways.Conclusions: The Precision Paradigm is a promising resource to accelerate innovative cross-model research to clarify which interventions within home visiting work best for which families, in which contexts, why and how.
A Novel Thioredoxin Homologous Protein of Babesia Microti Involved in Erythrocyte Invasion
Authors: Piao Xianyu , Ma Yu , Liu Shuai , Cai Pengfei , Hou Nan , Chen Qijun 
Published: January 2021

Abstract
Background: Erythrocyte invasion by merozoites is an important stage in the life cycle of Babesia microti. Several merozoite proteins have previously been demonstrated to play important roles in this process. Methods and Results: We identified a novel merozoite protein of B. microti with structural characteristics similar to those of the thioredoxin (Trx)-like domain of the Trx family and named it as BmiTrx-like protein. Western blot assays demonstrated that this protein was continuously expressed throughout the erythrocyte phase and peaked on the 11th day post-infection. Immunofluorescence assay showed that the protein might mainly be expressed on the membrane of B. microti merozoites. BmiTrx-like protein had both heparin- and erythrocyte-binding properties, which are critical functions of the invasion-related proteins. Immunization with recombinant BmiTrx-like protein imparted considerable protection against B. microti infection in mice. Conclusions: These results suggest that the novel merozoite protein, BmiTrx-like protein, is an important molecule in the invasion process of B. microti and may be a possible target for the design of babesiosis vaccines.
Two-Stage Total Knee Arthroplasty in the Treatment of Advanced&nbsp;Knee Septic Arthritis: Case Series
Authors: Wang Hong , Teng Yuanjun , Wang Xingwen , Zhang Shifeng , Xu Tianen , HAN Hua , Xia Yayi 
Published: January 2021

Abstract
PURPOSE: Septic arthritis (SA) is defined as the joint inflammation secondary to bacterial infection with a potentially fatal condition, but with no established approach treatment currently. Two-stage primary total knee arthroplasty (TKA) with an antibiotic-laden cement spacer has been reported to apply to treat SA of knee effectively in individual cases. We reported our cases aimed to contribute to current information on two-stage TKA in the treatment of advanced SA in knee joint.Methods: We retrospectively screened clinical profiles of eleven patients with SA in knee joint who had two-stage TKA with an antibiotic-laden cement spacer. Information of inflammatory serological markers were summarized and statistic comparisons were done on Hospital for Special Surgery (HSS) score as well as the degree of the range of motion (ROM) between pre-, interval- and post-operation, with significant level of p<0.05.Results: Infection in knee joint was eliminated in all eleven patients by two-stage TKA with an antibiotic-laden cement spacer. CRP took 3.4 ± 1.4 weeks (range, 1-6 weeks) to return to normal level, whilst for ESR was 16.3 ± 3.0 weeks (range, 13-23 weeks). Means of HSS score and ROM degree were significantly increased after both the first and second-stage surgery (p<0.05). HSS score of three timings were not different in age, gender, micro-organism culture results and comorbidities in our study.Conclusions: Two-stage TKA is an effective treatment in SA in knee joint in controlling infection, relieving clinical severity and improving function of keen joint thereafter.Level of evidence IV.
Regulation by Progestins, Corticosteroids and RU486 of Activation of Elephant Shark and Human Progesterone Receptors: An Evolutionary Perspective
Authors: Lin Xiaozhi , Takagi Wataru , Hyodo Susumu , Ijiri Shigeho , Katsu Yoshinao , Baker Michael 
Published: January 2021

Abstract
We investigated progestin and corticosteroid activation of the progesterone receptor (PR) from elephant shark (Callorhinchus milii), a cartilaginous fish belonging to the oldest group of jawed vertebrates. Comparison with human PR experiments provides insights into the evolution of steroid activation of human PR. At 1 nM steroid, elephant shark PR is activated by progesterone, 17-hydroxy-progesterone, 20b-hydroxy-progesterone, 11-deoxycorticosterone (21-hydroxyprogesterone) and 11-deoxycortisol. At 1 nM steroid, human PR is activated only by progesterone and11-deoxycorticosterone indicating increased specificity for progestins and corticosteroids during the evolution of human PR. RU486, an important clinical antagonist of human PR, did not inhibit progesterone activation of elephant shark PR. Cys-528 in elephant shark PR corresponds to Gly-722 in human PR, which is essential for RU486 inhibition of human PR. Confirming the importance of this site on elephant shark PR, RU486 inhibited progesterone activation of the Cys528Gly mutant PR. There also was a decline in activation of elephant shark Cys528Gly PR by 11-deoxycortisol, 17-hydroxy-progesterone and 20b-hydroxy-progesterone and an increase in activation of human Gly722Cys PR by 11-deoxycortisol and decreased activation by corticosterone. One or more of these changes may have selected for the mutation corresponding to human glycine-722 PR that first evolved in platypus PR, a basal mammal.
LINC00680 enhances hepatocellular carcinoma stemness behavior and chemoresistance by sponging miR-568 to upregulate AKT3
Authors: Shu Gege , Su Huizhao , Wang Zhiqian , Lai Shihui , Wang Yan , Liu Xiaomeng , Dai Luo , Bi Yin , Chen Wei , Huang Weiyu , Zhou Ziyan , He Songqing , Dai Hongliang , Tang Bo 
Published: January 2021

Abstract
Background: Hepatocellular carcinoma (HCC) has an extremely poor prognosis due to the development of chemoresistance, coupled with inherently increased stemness properties. Long non-coding RNAs (LncRNAs) are key regulators for tumor cell stemness and chemosensitivity. Currently the relevance between LINC00680 and tumor progression was still largely unknown, with only one study showing its significance in glioblastoma. The study herein was aimed at identifying the role of LINC00680 in the regulation HCC stemness and chemosensitivity. Methods: QRT-PCR was used to detect the expression of LINC00680, miR-568 and AKT3 in tissue specimen and cell lines. Gain- or loss-of function assays were applied to access the function of LINC00680 in HCC cells, including cell proliferation and stemness properties. HCC stemness and chemosensitivity were determined by sphere formation, cell viability and colony formation. Luciferase reporter, RNA immunoprecipitation (RIP), and RNA pull-down assays were performed to examine the interaction between LINC00680 and miR-568 as well as that between miR-568 and AKT3. A nude mouse xenograft model was established for the in vivo study.Results: We found that LINC00680 was remarkably upregulated in HCC tissues. Patients with high level of LINC00680 had poorer prognosis. LINC00680 overexpression significantly enhanced HCC cell stemness and decreased in vitro and in vivo chemosensitivity to 5-fluorouracil (5-Fu), whereas LINC00680 knockdown led to opposite results. Mechanism study revealed that LINC00680 regulated HCC stemness and chemosensitivity through sponging miR-568, thereby expediting the expression of AKT3, which further activated its downstream signaling molecules, including mTOR, elF4EBP1, and p70S6K.Conclusion: LINC00680 promotes HCC stemness properties and decreases chemosensitivity through sponging miR-568 to activate AKT3, suggesting that LINC00680 might be a potentially important HCC diagnosis marker and therapeutic target.
The Use of Medicinal Plants to Prevent COVID-19 in Nepal
Authors: Khadka Dipak , Dhamala Man Kumar , Li Feifei , Aryal Prakash Chandra , Magar Pappu Rana , Bhatta Sijar , Thakur Manju Shree , Basnet Anup , Shi Shi , Cui Dafang 
Published: January 2021

Abstract
Background: Medicinal plants are the fundamental unit of traditional medicine system in Nepal. Nepalese people are rich in traditional medicine especially in folk medicine (ethnomedicine) and this system is gaining much attention after 1995. The use of medicinal plants have increased during COVID-19 pandemic as a private behavior (not under the control of government). Lot of misinterpretations of the use of medicinal plants to treat or prevent COVID-19 have been spreading throughout Nepal which need to be managed proactively. In this context, a research was needed to document medicinal plants used, their priority of use in society, cultivation status and source of information people follow to use them. This study aimed to document the present status of medicinal plant use and make important suggestion to the concern authorities.Methods: This study used a web-based survey to collect primary data related to medicinal plants used during COVID-19. A total of 774 respondents took part in the survey. The study calculated the relative frequencies of citation (RFC) for the recorded medicinal plants. The relationship between plants recorded and different covariates (age, gender education, occupation, living place, and treatment methods were assessed using Kruskal Wallis test and Wilcox test. The relationship between the information sources people follow and respondent characteristics, were assessed using chi-square test.Results: The study found that the use of medicinal plants has increased during COVID-19 and most of the respondents recommended medicinal plants to prevent COVID-19. This study recorded a total of 60 plants belonging to 36 families. The leaves of the plants were the most frequently used. The Zingiber officinale was the most cited species with the frequency of citation 0.398. Most of the people (45.61%), were getting medicinal plants from their home garden. The medicinal plants recorded were significantly associated with the education level, location of home, primary treatment mode, gender, and age class. The information source of plants was significantly associated with the education, gender, method of treatment, occupation, living with family, and location of home during lockdown caused by COVID-19.Conclusions: People were using more medicinal plants during COVID-19 claiming that they can prevent or cure COVID-19. This should be taken seriously by concerned authorities. The authorities should test the validity of these medicinal plants and control the flow of false information spread through research and awareness programs.
Characteristics and chemical reactivity of biogenic volatile organic compounds from dominant forest species in the Jing-Jin-Ji area, China
Authors: Lin Ying , Lun Xiaoxiu , Tang Wei , Zhang Zhongzhi , Jing Xiaoxi , Fan Chong 
Published: January 2021

Abstract
Background: Biogenic volatile organic compounds (BVOCs) play an essential role in tropospheric atmospheric chemical reactions. There are few studies conducted on BVOCs emissions of dominant forest species in the Jing-Jin-Ji area. Based on the field survey, forest resources data and the measured standard emission factors, this paper applies the Guenther model developed in 1993 (G93) to estimate the emissions of BVOCs from several dominant forest species (Platycladus orientalis, Quercus variabilis, Betula platyphylla, Populus tomentosa, Pinus tabuliformis, Robinia pseudoacacia, Ulmus pumila, Salix babylonica and Larix gmelinii) in the Jing-Jin-Ji area in 2017. Then the spatiotemporal emission characteristics and atmospheric chemical reactivity of these species were extensively evaluated. Results: Results showed that the total annual BVOCs emissions were estimated to be 70.8 Gg C·a-1, consisting of 40.5% (28.7 Gg C·a-1) isoprene, 36.0% (25.5 Gg C·a-1) monoterpenes and 23.4% (16.6 Gg C·a-1) other VOCs. The emissions from Platycladus orientalis, Quercus variabilis, Populus tomentosa and Pinus tabulaeformis contributed 56.1%, 41.2%, 36.0% and 31.1%, respectively. In summer and winter, BVOCs emissions from the Jing-Jin-Ji area accounted for 61.9% and 1.8% of the annual total. Up to 28.8% of emissions were detected from Chengde followed by Beijing with 24.9%, mainly distributed in the Taihang Mountains and the Yanshan Mountains. Additionally, the Robinia pseudoacacia, Populus tomentosa, Quercus variabilis, and Pinus tabulaeformis contributed mainly to BVOCs reaction activity. Conclusions: Emissions peaked in summer (June, July, and August) and bottomed out in winter (December, January, and February). Chengde contributed the most, followed by Beijing. Platycladus orientalis, Quercus variabilis, Populus tomentosa, Pinus tabulaeformis and Robinia pseudoacacia represent the primary contributors to BVOCs emissions and atmospheric reactivity, hence the planting of these species should be reduced.
Edith Stein: de la concepción de la persona humana a la comprensión de la mujer
Authors: Reyes-Gacitúa Eva 
Published: January 2021

Actualmente, «pensar la mujer» constituye una tarea inacabada y debatida. En pleno siglo XX, la fenomenóloga Edith Stein explora tal despliegue interrogándose por su naturaleza y valor propio. La presente investigación expone el itinerario que establece la filósofa desde la reflexión de la persona humana a la comprensión de la mujer.
Para tal efecto, se articulan desde la obra steiniana los principales conceptos y matices que, mediante el análisis fenomenológico posibilita examinar las nociones constituyentes del sujeto en su dimensión corporal y espiritual. Finalmente, se esboza la peculiaridad de la esencia femenina, cuya indagación permite detenerse en la pregunta esencial por la mujer. La conclusión avanza hacia un balance de los principales aspectos desarrollados como aporte al diálogo contemporáneo.
Reseña. Roggero, Jorge Luis ed. El fenómeno saturado. La excedencia de la donación en la fenomenología de Jean-Luc Marion. Buenos Aires: SB editorial, 2020
Authors: Roldán Alberto Fernando 
Published: January 2021

Reseña
Roggero, Jorge Luis ed. El fenómeno saturado. La excedencia de la donación en la fenomenología de Jean-Luc Marion. Buenos Aires: SB editorial, 2020
LEMBAR KERJA SISWA PADA MATERI HIMPUNAN BERBASIS PENDEKATAN PENDIDIKAN MATEMATIKA REALISTIK UNTUK SISWA SMP/MTs
Authors: Arfinanti Nurul 
Published: January 2021

Penelitian ini merupakan penelitian pengembangan. Penelitian ini bertujuan untuk mengembangkan lembar kerja siswa (LKS) berbasis Pendekatan Pendidikan Matematika Realistik pada materi himpunan un- tuk siswa SMP/MTs.Model pengembangan yang digunakan adalah model pengemban- gan prosedural, yaitu model yang bersifat deskriptif, menggariskan lang- kah-langkah yang harus diikuti untuk menghasilkan produk. Prosedur pengembangan yang digunakan dalam penelitian ini adalah prosedur pengembangan Borg dan Gall yang disederhanakan dengan lima langkah yaitu melakukan analisis produk yang dikembangkan, mengembangkan produk awal, validasi ahli dan revisi, uji coba lapangan skala kecil dan revisi produk, serta uji coba lapangan skala besar dan produk akhir.Hasil penelitian adalah Lembar Kerja Siswa berbasis pendekatan PMR dengan kualitas keseluruhan sangat baik dengan nilai 70 (90, 35%). LKS juga sangat efektif digunakan untuk pembelajaran matematika SMP/ MTs. Hal ini berdasarkan ketuntasan siswa secara klasikal dengan persen- tase 82,86%. Selain itu, respon siswa juga positif terhadap pembelajaran dengan menggunakan LKS pendekatan PMR.
Electrochemical Fabrication of Poly (niacin) Modified Graphite Paste Electrode and its Application for the Detection of Riboflavin
Authors: Manjunatha J. G. , Raril C. , Hareesha N. , Charithra M.M. , Pushpanjali P.A. , Tigari Girish , Ravishankar D.K , Mallappaji S. C. , Gowda Jayarame 
Published: January 2021

Objective:A poly niacin (NN) modified graphite paste electrode was prepared through a simple electrochemical polymerization route for the determination of Riboflavin (RF)Methods:Electropolymerization technique was used for the preparation of a modified electrode. The electrochemical impedance spectroscopy (EIS) method was used to study the surface behaviors and conductivity of the bare and modified electrodes. Cyclic voltammetry (CV) and linear sweep voltammetry (LSV) were used to study the electrochemical behavior of RF using 0.2 M PBS of 7.5 pH.Results:Poly niacin modified graphite paste electrode (PNNMGPE) provides more affinity towards RF detection with high sensitivity and selectivity over bare graphite paste electrode. RF calibration curve was obtained by LSV between 5.0 µM to 65.0 µM with 0.782 µM limit of detection (LOD) and 2.7608 µM limit of quantification (LOQ), respectively. Selective analysis of RF in the presence of ascorbic acid (AA) and dopamine (DA) was performed at PNNMGPE by the LSV method.Conclusion:The developed PNNMGPE was tested for RF analysis in a multivitamin tablet with good results. Furthermore, the developed electrode shows good stability and reproducibility.
Insights on Using Social Media in Dental Education: A Cross-Sectional Study in Saudi Arabia
Authors: Rajeh Mona T. , Aboalshamat Khalid T. , Nassar Afnan A. , Sembawa Shahinaz N. , Al Hebshi Seba A. , Badri Mohammad K. 
Published: January 2021

Objective:
The purpose of this study is to investigate the insight of utilizing social media as an educational tool among dental faculty members in Saudi Arabia.

Methods:
A descriptive cross-sectional survey was distributed to 380 randomly selected faculty members from three governmental universities in the Western region of Saudi Arabia. The participants completed a validated questionnaire to assess the intent of using social media and their opinion about the benefits and drawbacks of adopting social media as an educational tool. Descriptive statistics and chi-square test were used to analyse the results.

Results:
Out of 380 faculty members who were invited to participate, 271 responded (71% response rate). Results reveal that WhatsApp, followed by YouTube, Facebook, and Twitter were the mostly used social media platforms. Around 31% of the participants reported using social media for ten hours or more. The main reason reported by the participants for using social media was searching for information (82.17%), followed by professional networking (78.29%) and learning (75.97%). The majority of the participants agreed that social media have advantages like it helps students to communicate and share ideas with instructors, update students with new resources, and improve students’ skills. Social media also has several disadvantages; the respondents believe that it can increase their addictive potential, create more demand for internet access, and raise concerns on direct contact with students.

Conclusion:
As an educational tool, social media can enrich the teaching experience by using the appropriate strategies. The findings may be useful for educators to adopt social media platforms in dental education.
The Effect of Topical Anesthetic Gel versus Relaxation Exercise in Controlling the Pain of Anterior Maxillary Injection
Authors: Omidpanah Neda , Shahrzad Nematollahi , Safari Roya 
Published: January 2021

Background and Aim:Adequate intraoral anesthesia is a major prerequisite for many dental procedures. Bubble breath exercise, distraction, and play therapy technique may be used as relaxation exercises to decrease pain. This study aimed to compare the efficacy of bubble breath exercise versus topical anesthetic gel in controlling the pain of anterior maxillary infiltration.Methods:This crossover clinical trial was performed on 50 children aged 10-12 years. Subjects received a total of 100 maxillary injections (two per person) in the buccal mucosal area of canine teeth of both sides at intervals of 2 to 3 days. On one side, the injection was performed after applying 20% benzocaine gel. On the other side, a similar injection was performed after the bubble breath exercise. The injection solution was 1/4 of 1.8 mL cartridge of 2% lidocaine containing 1:200,000 epinephrine using a 30-gauge needle. The pain was measured immediately after anesthesia injection using a Visual Analogue Scale (VAS). Data analysis was carried out using SPSS Version 18.0 (IBM Inc., Chicago, IL, USA). Wilcoxon signed-rank tests were used to compare with the 10-mm visual analog scale (VAS) scores obtained from all participants. The level of significance was considered at 5% (p <0.05). The correlation between gender and pain score (VAS) for the two methods was analyzed using the Mann-Whitney U test.Results:The results showed no statistically significant difference between injection pain after topical anesthetic gel application and injection pain after bubble breath exercise (p value=0.30). Also, no statistically significant difference was found between injection pain after gel application and injection pain after bubble breath exercise in boys (p value=0.59) or girls (p value=0.32). There were statistically significant differences between boys and girls in terms of injection pain after gel application (p value=0.001) and also injection pain after e bubble breath exercise (pvalue=0.004).Conclusion:There is no significant difference between perceived injection pain after bubble breath exercise and after applying the topical anesthetic gel. Furthermore, future studies should explore the role of age, dental fear, and anxiety, previous painful experiences, the pain thresholds.