bluuebunny/crossref_metadata_2025_split huggingface dataset:
Navigating Deaf and Hearing Cultures: An Exploration of Deaf Acculturative Stress
Authors: Aldalur Aileen , Pick Lawrence H , Schooler Deborah 
Published: May 2021

Abstract
While there are many benefits of bilingualism and biculturalism, it is increasingly recognized that individuals may also experience acculturative stress as they navigate between different cultural environments. Acculturative stress results from struggles to acculturate, including pressures from the dominant culture and one’s heritage culture to maintain specific languages, values, and customs. This study sought to explore experiences of acculturative stress among Deaf and Hard of Hearing (DHH) adults. Thirteen ethnically and racially diverse DHH adults, aged 21–52, participated in semi-structured focus groups. Krueger’s (1994) framework analysis was used to analyze the data. Participants reported pressures from the Hearing community as Hearing, Speaking, and English Pressures; Hearing Cultural Expectations; and Family Marginalization. Pressures from the Deaf community included ASL Pressures; Deaf Cultural Expectations; and Small Community Dynamics. Participants also discussed unique stressors related to their intersecting cultural identities (Intersectionality). The psychosocial impacts of acculturative stress included anger, anxiety, depression, exhaustion, resentment, and trauma. Coping resources were also discussed. Results highlight the saliency of acculturative stress among DHH adults and the need for continued investigations of the construct, particularly as it relates to mental health.
Participation in exercise-based cardiac rehabilitation is related to reduced total mortality in both men and women: results from the SWEDEHEART registry
Authors: Ekblom Örjan , Cider Åsa , Hambraeus Kristina , Bäck Maria , Leosdottir Margrét , Lönn Amanda , Börjesson Mats 
Published: May 2021

Abstract

Aims
Participation in exercise-based cardiac rehabilitation (exCR) increases aerobic capacity and improves outcomes in patients following myocardial infarction (MI) and is therefore universally recommended. While meta-analyses consistently report that participation in exCR reduces cardiovascular mortality, there are conflicting results regarding effects on total mortality. Presently, many eligible patients do not receive exCR in clinical practice. We aimed to investigate the relation between participation in exCR post-MI and total mortality in men and women in a nationwide real-world cohort from the SWEDEHEART registry.

Design
Longitudinal, observational cohort study.

Methods and results
In total, 20 895 patients from the SWEDEHEART registry were included. Mortality data were obtained from the Swedish National Population Registry. During a mean of 4.55 (±2.33) years of follow-up, 1000 patients died. Using Cox regression for proportional odds and taking a wide range of potential confounders into consideration, participation in exCR was related to significantly lower total mortality [hazard ratio (HR) 0.72, 95% confidence interval 0.62–0.83]. Excluding patients with shorter follow-up than 2 years did not alter the results. Exercise-based CR participation was related to lowered total mortality in most of the investigated subgroups. The risk reduction was more pronounced in women than in men (HR 0.54 vs. 0.81, respectively).

Conclusion
Participation in exCR was associated with reduced total mortality, and more pronounced in women, compared with men. Our results further support the recommendations to participate in exCR, and hence we argue that exCR should be a mandatory part of comprehensive CR programmes, offered to all patients post-MI.
The Toll of Feeling Older: Subjective Age Moderates the Associations Between Anxiety Sensitivity and Symptoms of Anxiety and Depression During the COVID-19 Epidemic
Authors: Avidor Sharon , Abu Hamam Asmaa , Lahav Yael 
Published: May 2021

Abstract

Objectives
The coronavirus disease 2019 (COVID-19) pandemic is an ongoing stressor that may have detrimental effects on mental health. Theoretical and empirical literature implies that individuals who are characterized by catastrophic appraisals of somatic cues, a tendency known as anxiety sensitivity, as well as by older subjective age, might be particularly vulnerable to depression and anxiety during the pandemic. Furthermore, subjective age might moderate the relations between anxiety sensitivity with depression and anxiety symptoms. Yet, research to date has not explored the contribution of both anxiety sensitivity and subjective age in explaining distress following stress in general, nor in light of the current COVID-19 pandemic.

Method
Filling this gap, a convenience sample of 828 participants (Mage = 43.98, SD = 14.06) filled questionnaires measuring background variables, COVID-19–related stressors, anxiety sensitivity, subjective age, and anxiety and depression symptoms during the pandemic.

Results
Positive associations were found between anxiety sensitivity and subjective age, on the one hand, and anxiety and depression symptoms, on the other. Furthermore, subjective age moderated the relations between anxiety sensitivity with depression and anxiety symptoms. Although higher levels of anxiety sensitivity were related to depression and anxiety during the pandemic, these relations were significantly stronger among participants with an older subjective age.

Discussion
The findings are consistent with theories that view subjective age as an intraindividual construct involved in modulating important mental health outcomes in the context of coping with stress.
An innovative leadership development initiative to support building everyday resilience in health systems
Authors: Nzinga Jacinta , Boga Mwanamvua , Kagwanja Nancy , Waithaka Dennis , Barasa Edwine , Tsofa Benjamin , Gilson Lucy , Molyneux Sassy 
Published: May 2021

Abstract
Effective management and leadership are essential for everyday health system resilience, but actors charged with these roles are often underprepared and undersupported to perform them. Particular challenges have been observed in interpersonal and relational aspects of health managers’ work, including communication skills, emotional competence and supportive oversight. Within the Resilient and Responsive Health Systems (RESYST) consortium in Kenya, we worked with two county health and hospital management teams to adapt a package of leadership development interventions aimed at building these skills. This article provides insights into: (1) the content and co-development of a participatory intervention combining two core elements: a complex health system taught course, and an adapted communications and emotional competence process training; and (2) the findings from a formative evaluation of this intervention which included observations of the training, individual interviews with participating managers and discussions in regular meetings with managers. Following the training, managers reported greater recognition of the importance of health system software (values, belief systems and relationships), and improved self-awareness and team communication. Managers appeared to build valued skills in active listening, giving constructive feedback, ‘stepping back’ from automatic reactions to challenging emotional situations and taking responsibility to communicate with emotional competence. The training also created spaces for managers to share experiences, reflect upon and nurture social competences. We draw on our findings and the literature to propose a theory of change regarding the potential of our leadership development intervention to nurture everyday health system resilience through strengthening cognitive, behavioural and contextual capacities. We recommend further development and evaluation of novel approaches such as those shared in this article to support leadership development and management in complex, hierarchical systems.
Increasing LRP4 diminishes neuromuscular deficits in a mouse model of Duchenne muscular dystrophy
Authors: Hui Tiankun , Jing Hongyang , Zhou Tian , Chen Peng , Liu Ziyang , Dong Xia , Yan Min , Ren Dongyan , Zou Suqi , Wang Shunqi , Fei Erkang , Hong Daojun , Lai Xinsheng 
Published: May 2021

Abstract
Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disease characterized by progressive wasting of skeletal muscles. The neuromuscular junction (NMJ) is a synapse between motor neurons and skeletal muscle fibers, critical for the control of muscle contraction. The NMJ decline is observed in DMD patients, but the mechanism is unclear. LRP4 serves as a receptor for agrin, a proteoglycan secreted by motor neurons to induce NMJ, and plays a critical role in NMJ formation and maintenance. Interestingly, we found that protein levels of LRP4 were reduced both in muscles of the DMD patients and DMD model mdx mice. We explored whether increasing LRP4 is beneficial for DMD and crossed muscle-specific LRP4 transgenic mice with mdx mice (mdx; HSA-LRP4). The LRP4 transgene increased muscle strength, together with improved neuromuscular transmission in mdx mice. Furthermore, we found the LRP4 expression mitigated NMJ fragments and denervation in mdx mice. Mechanically, we showed that overexpression of LRP4 increased the activity of MuSK and expression of dystrophin-associated glycoprotein complex proteins in the mdx mice. Overall, our findings suggest that increasing LRP4 improves both function and structure of NMJ in the mdx mice and Agrin signaling might serve as a new therapeutic strategy in DMD.
Beyond catch-up: could China become the global innovation powerhouse? China’s innovation progress and challenges from a holistic innovation perspective
Authors: Chen Jin , Yin Ximing , Fu Xiaolan , McKern Bruce 
Published: May 2021

AbstractOver the past century and a half, global technological leadership has shifted from Europe to the United States, while scholars argue that the world has seen that it is now shifting from the United States to China due to China’s extraordinary catch-up in the past four decades, in which the public policy-oriented national innovation system development plays a critical role that might provide an alternative way for innovation-driven development especially for emerging markets. Even though encountering many challenges ahead, China is positioning itself to take over the global innovation leadership in the next few decades. Here in this article, we introduce a serious yet underexplored question: could China go beyond catch-up and become the global innovation powerhouse? Specifically, drawing from the holistic innovation perspective, which is an original theoretical paradigm for the mission-oriented innovation policy change, this article critically reviews, both qualitatively and quantitatively, China’s remarkable innovation progress and main drivers in comparison with G7 countries plus South Korea and India, trying to provide a comprehensive and critical view of state-of-the-art research on China’s innovation catch-up. We further explore the five major challenges that China must take seriously when marching toward the global innovation powerhouse. Finally, we propose a mission-oriented holistic STI policy design framework for both China and other emerging economies to go beyond catch-up in a competitive dynamic world. This article provides a new and holistic perspective to access China’s innovation progress and challenges, also generates novel insights for scholars and public agencies to contribute to global innovation development, with a shared goal of achieving global sustainable development in the post-COVID-19 pandemic world.
Constructing and adjusting estimates for household transmission of SARS-CoV-2 from prior studies, widespread-testing and contact-tracing data
Authors: Curmei Mihaela , Ilyas Andrew , Evans Owain , Steinhardt Jacob 
Published: May 2021

Abstract

Background
With reduced community mobility, household infections may become increasingly important in SARS-CoV-2 transmission dynamics.

Methods
We investigate the intra-household transmission of COVID-19 through the secondary-attack rate (SAR) and household reproduction number (Rh). We estimate these using (i) data from 29 prior studies (February–August 2020), (ii) epidemiologically linked confirmed cases from Singapore (January–April 2020) and (iii) widespread-testing data from Vo’ (February–March 2020). For (i), we use a Bayesian random-effects model that corrects for reverse transcription–polymerase chain reaction (RT–PCR) test sensitivity and asymptomatic cases. We investigate the robustness of Rh with respect to community transmission rates and mobility patterns.

Results
The corrected pooled estimates from prior studies for SAR and Rh are 24% (20–28%) and 0.34 (0.30–0.38), respectively. Without corrections, the pooled estimates are: SAR = 18% (14–21%) and Rh = 0.28 (0.25–0.32). The corrected estimates line up with direct estimates from contact-tracing data from Singapore [Rh = 0.32 (0.22–0.42)] and population testing data from Vo’ [SAR = 31% (28–34%) and Rh = 0.37 (0.34–0.40)]. The analysis of Singapore data further suggests that the value of Rh (0.22–0.42) is robust to community-spread dynamics; our estimate of Rh stays constant whereas the fraction of infections attributable to household transmission (Rh/Reff) is lowest during outbreaks (5–7%) and highest during lockdowns and periods of low community spread (25–30%).

Conclusions
The three data-source types yield broadly consistent estimates for SAR and Rh. Our study suggests that household infections are responsible for a large fraction of infections and so household transmission may be an effective target for intervention.
On p-adic Versions of the Manin–Mumford Conjecture
Authors: Serban Vlad 
Published: May 2021

Abstract
We establish $p$-adic versions of the Manin–Mumford conjecture, which states that an irreducible subvariety of an abelian variety with dense torsion has to be the translate of a subgroup by a torsion point. We do so in the context of certain rigid analytic spaces and formal groups over a $p$-adic field or its ring of integers, respectively. In particular, we show that the underlying rigidity results for algebraic functions generalize to suitable $p$-adic analytic functions. This leads us to uncover purely $p$-adic Manin–Mumford-type results for formal groups not coming from abelian schemes. Moreover, we observe that a version of the Tate–Voloch conjecture holds: torsion points either lie squarely on a subscheme or are uniformly bounded away from it in the $p$-adic distance.
Rapid spread of critical priority carbapenemase-producing pathogens in companion animals: a One Health challenge for a post-pandemic world
Authors: Sellera Fábio P. , Da Silva Luciano C. B. A. , Lincopan Nilton 
Published: May 2021

Abstract
The COVID-19 pandemic has increased relationships and interactions between human and companion animals, supported by widespread social distancing and isolation measures. Additionally, the COVID-19 pandemic has led to an exponential growth in antibiotic and biocide use worldwide, possibly inducing further pressure, contributing to the selection of antibiotic-resistant bacteria, including WHO critical priority pathogens. While data from global surveillance studies reveal a linear trend of increasing carbapenem resistance among Gram-negative pathogens from companion animals, the acquisition of carbapenemase-producing Enterobacterales through direct contact with colonized hosts and contaminated veterinary hospital environments has been documented. This article highlights the rapid spread of WHO critical priority carbapenemase-producing pathogens in companion animals, which is a One Health challenge for a post-pandemic world.
Integrated digital pathology at scale: A solution for clinical diagnostics and cancer research at a large academic medical center
Authors: Schüffler Peter J , Geneslaw Luke , Yarlagadda D Vijay K , Hanna Matthew G , Samboy Jennifer , Stamelos Evangelos , Vanderbilt Chad , Philip John , Jean Marc-Henri , Corsale Lorraine , Manzo Allyne , Paramasivam Neeraj H G , Ziegler John S , Gao Jianjiong , Perin Juan C , Kim Young Suk , Bhanot Umeshkumar K , Roehrl Michael H A , Ardon Orly , Chiang Sarah , Giri Dilip D , Sigel Carlie S , Tan Lee K , Murray Melissa , Virgo Christina , England Christine , Yagi Yukako , Sirintrapun S Joseph , Klimstra David , Hameed Meera , Reuter Victor E , Fuchs Thomas J 
Published: May 2021

AbstractObjectiveBroad adoption of digital pathology (DP) is still lacking, and examples for DP connecting diagnostic, research, and educational use cases are missing. We blueprint a holistic DP solution at a large academic medical center ubiquitously integrated into clinical workflows; researchapplications including molecular, genetic, and tissue databases; and educational processes.Materials and MethodsWe built a vendor-agnostic, integrated viewer for reviewing, annotating, sharing, and quality assurance of digital slides in a clinical or research context. It is the first homegrown viewer cleared by New York State provisional approval in 2020 for primary diagnosis and remote sign-out during the COVID-19 (coronavirus disease 2019) pandemic. We further introduce an interconnected Honest Broker for BioInformatics Technology (HoBBIT) to systematically compile and share large-scale DP research datasets including anonymized images, redacted pathology reports, and clinical data of patients with consent.ResultsThe solution has been operationally used over 3 years by 926 pathologists and researchers evaluating 288 903 digital slides. A total of 51% of these were reviewed within 1 month after scanning. Seamless integration of the viewer into 4 hospital systems clearly increases the adoption of DP. HoBBIT directly impacts the translation of knowledge in pathology into effective new health measures, including artificial intelligence–driven detection models for prostate cancer, basal cell carcinoma, and breast cancer metastases, developed and validated on thousands of cases.ConclusionsWe highlight major challenges and lessons learned when going digital to provide orientation for other pathologists. Building interconnected solutions will not only increase adoption of DP, but also facilitate next-generation computational pathology at scale for enhanced cancer research.
Clinically relevant pretraining is all you need
Authors: Bear Don’t Walk IV Oliver J , Sun Tony , Perotte Adler , Elhadad Noémie 
Published: May 2021

Abstract
Clinical notes present a wealth of information for applications in the clinical domain, but heterogeneity across clinical institutions and settings presents challenges for their processing. The clinical natural language processing field has made strides in overcoming domain heterogeneity, while pretrained deep learning models present opportunities to transfer knowledge from one task to another. Pretrained models have performed well when transferred to new tasks; however, it is not well understood if these models generalize across differences in institutions and settings within the clinical domain. We explore if institution or setting specific pretraining is necessary for pretrained models to perform well when transferred to new tasks. We find no significant performance difference between models pretrained across institutions and settings, indicating that clinically pretrained models transfer well across such boundaries. Given a clinically pretrained model, clinical natural language processing researchers may forgo the time-consuming pretraining step without a significant performance drop.
Short communication: investigation of the feasibility of genomic selection in Icelandic Cattle
Authors: Gautason Egill , Sahana Goutam , Su Guosheng , Benjamínsson Baldur Helgi , Jóhannesson Guðmundur , Guldbrandtsen Bernt 
Published: May 2021

Abstract
Icelandic Cattle is a local dairy cattle breed in Iceland. With about 26,000 breeding females, it is by far the largest among the indigenous Nordic cattle breeds. The objective of this study was to investigate the feasibility of genomic selection in Icelandic Cattle. Pedigree-based best linear unbiased prediction (PBLUP) and single-step genomic best linear unbiased prediction (ssGBLUP) were compared. Accuracy, bias, and dispersion of estimated breeding values (EBV) for milk yield (MY), fat yield (FY), protein yield (PY), and somatic cell score (SCS) were estimated in a cross validation-based design. Accuracy (r^) was estimated by the correlation between EBV and corrected phenotype in a validation set. The accuracy (r^) of predictions using ssGBLUP increased by 13, 23, 19, and 20 percentage points for MY, FY, PY, and SCS for genotyped animals, compared with PBLUP. The accuracy of nongenotyped animals was not improved for MY and PY, but increased by 0.9 and 3.5 percentage points for FY and SCS. We used the linear regression (LR) method to quantify relative improvements in accuracy, bias (Δ^), and dispersion (b^) of EBV. Using the LR method, the relative improvements in accuracy of validation from PBLUP to ssGBLUP were 43%, 60%, 50%, and 48% for genotyped animals for MY, FY, PY, and SCS. Single-step GBLUP EBV were less underestimated (Δ^), and less overdispersed (b^) than PBLUP EBV for FY and PY. Pedigree-based BLUP EBV were close to unbiased for MY and SCS. Single-step GBLUP underestimated MY EBV but overestimated SCS EBV. Based on the average accuracy of 0.45 for ssGBLUP EBV obtained in this study, selection intensities according to the breeding scheme of Icelandic Cattle, and assuming a generation interval of 2.0 yr for sires of bulls, sires of dams and dams of bulls, genetic gain in Icelandic Cattle could be increased by about 50% relative to the current breeding scheme.
Enforcement against the Biggest Banks
Authors: Zaring David 
Published: May 2021

ABSTRACT
Being a big bank means the regular payment of huge fines to a number of different regulators, paired with profuse apologies, and promises to do better next time. This article makes use of a hand-collected dataset to show how this enforcement worked in the United States after the passage of the Dodd-Frank Wall Street Reform Act. American regulators have tended to hunt the big banks in packs, with multiple regulators pursuing fines against financial institutions for the same misconduct. Regulators frequently enforce in a ‘viral’ manner: once they sanction one bank for a type of misconduct, the chances that they will sanction another bank for the same sort of misconduct increases. Some regulators like to bundle a variety of different unlawful actions by banks into one global settlement. Enforcement by the Department of Justice can result in spectacularly expensive settlements compared to the level of enforcement by primary banking regulatory agencies; overall, Department of Justice sanctions in dollars dwarf those of all other agencies policing part of what a bank does. American enforcement, despite suspicion to the contrary, does not appear to protect domestic banks and discriminate against foreign ones. Although this article’s primary goal is to make sense of the federal government’s overall enforcement practices, one recommendation is made: criminal prosecutors should consult with safety and soundness regulators before unveiling indictments and settlements against banks.