bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of various chemical compounds for the removal of SO2 and NOx with wet scrubbing for marine diesel engines
Authors: Chin Terence , Tam Ivan CK , Yin Chun-Yang 
Published: September 2021

AbstractSeawater, NaOH, NaClO, NaClO2, H2O2, and KMnO4 were used as scrubbing liquids to react with SOx and NOx separately in a customized wet scrubber. The absorption of SO2 in the aqueous phase was influenced by three factors: pH, ionic concentration, and oxidation potential. For NOx removal, the effectiveness of various chemical compounds can be ranked from least to most effective as follows: seawater, NaOH, H2O2 < NaClO < KMnO4 < NaClO2. This effectiveness was influenced by the chemical compound’s ability to oxidize NO to NO2, absorb the NO2 that was formed, and retaining the nitrogen in the aqueous phase. High oxidation potential promoted the oxidation of NO to NO2 but hindered the absorption of NO2. NaClO2 was superior compared to NaClO in all three categories of oxidizing, absorption and retention. NaClO could not retain a significant amount of NO2 which it absorbed in the aqueous phase. The pH around 8 provided a good balance between oxidation versus absorption/retention and reactant utilization for the chlorine-based oxidants. KMnO4 had the lowest reactant consumption rate; only half a mole was consumed for every mole of NO removed, compared to around 2–3 mol of chlorite or 3–5 mol of hypochlorite.
Autoantibodies in Rheumatoid Arthritis: Historical Background and Novel Findings
Authors: Sokolova Maria V. , Schett Georg , Steffen Ulrike 
Published: September 2021

AbstractAutoantibodies represent a hallmark of rheumatoid arthritis (RA), with the rheumatoid factor (RF) and antibodies against citrullinated proteins (ACPA) being the most acknowledged ones. RA patients who are positive for RF and/or ACPA (“seropositive”) in general display a different etiology and disease course compared to so-called “seronegative” patients. Still, the seronegative patient population is very heterogeneous and not well characterized. Due to the identification of new autoantibodies and advancements in the diagnosis of rheumatic diseases in the last years, the group of seronegative patients is constantly shrinking. Aside from antibodies towards various post-translational modifications, recent studies describe autoantibodies targeting some native proteins, further broadening the spectrum of recognized antigens. Next to the detection of new autoantibody groups, much research has been done to answer the question if and how autoantibodies contribute to the pathogenesis of RA. Since autoantibodies can be detected years prior to RA onset, it is a matter of debate whether their presence alone is sufficient to trigger the disease. Nevertheless, there is gathering evidence of direct autoantibody effector functions, such as stimulation of osteoclastogenesis and synovial fibroblast migration in in vitro experiments. In addition, autoantibody positive patients display a worse clinical course and stronger radiographic progression. In this review, we discuss current findings regarding different autoantibody types, the underlying disease-driving mechanisms, the role of Fab and Fc glycosylation and clinical implications.
Pre Versus Post Implementation of a Pharmacologic Antishivering Protocol During Targeted Temperature Management Following Cardiac Arrest
Authors: Huynh Calvin , Lui Jevons , Behbahani Vala , Thompson Quan Ashley , Morris Amanda , Baumgartner Laura 
Published: September 2021

Abstract
Background
Targeted temperature management (TTM) is endorsed by various guidelines to improve neurologic outcomes following cardiac arrest. Shivering, a consequence of hypothermia, can counteract the benefits of TTM. Despite its frequent occurrence, consensus guidelines provide minimal guidance on the management of shivering. The purpose of this study was to evaluate the impact of a pharmacologic antishivering protocol in patients undergoing TTM following cardiac arrest on the incidence of shivering.

Methods
A retrospective observational cohort study at a large academic medical center of adult patients who underwent TTM targeting 33 °C following out-of-hospital (OHCA) or in-hospital cardiac arrest (IHCA) was conducted between January 2013 and January 2019. Patients were included in the preprotocol group if they received TTM prior to the initiation of a pharmacologic antishivering protocol in 2015. The primary outcome was incidence of shivering between pre- and postprotocol patients. Secondary outcomes included time from arrest (IHCA) or admission to the hospital (OHCA) to goal body temperature, total time spent at goal body temperature, and percentage of patients alive at discharge. All pharmacologic agents listed as part of the antishivering protocol were recorded.

Results
Fifty-one patients were included in the preprotocol group, and 80 patients were included in the postprotocol group. There were no significant differences in baseline characteristics between the groups, including percentage of patients experiencing OHCA (75% vs. 63%, p = 0.15) and time from arrest to return of spontaneous circulation (17.5 vs. 17.9 min, p = 0.96). Incidence of patients with shivering was significantly reduced in the postprotocol group (57% vs. 39%, p = 0.03). Time from arrest (IHCA) or admission to the hospital (OHCA) to goal body temperature was similar in both groups (5.1 vs. 5.3 h, p = 0.57), in addition to total time spent at goal body temperature (17.7 vs. 18 h, p = 0.93). The percentage of patients alive at discharge was significantly improved in the postprotocol group (35% vs. 55%, p = 0.02). Patients in the postprotocol group received significantly more buspirone (4% vs. 73%, p < 0.01), meperidine (8% vs. 34%, p < 0.01), and acetaminophen (12% vs. 65%, p < 0.01) as part of the pharmacologic antishivering protocol. Use of neuromuscular blockade significantly decreased post protocol (19% vs. 6%, p = 0.02).

Conclusions
In patients undergoing TTM following cardiac arrest, the implementation of a pharmacologic antishivering protocol reduced the incidence of shivering and the use neuromuscular blocking agents. Prospective data are needed to validate the results and further evaluate the safety and efficacy of an antishivering protocol on clinical outcomes.
Transcatheter aortic valve replacement: impact of pre-procedural FEops HEARTguide assessment on device size selection in borderline annulus size cases
Authors: Halim J. , Brouwer J. , Lycke M. , Swaans M. J. , Van der Heyden J. 
Published: September 2021

Abstract
Objectives
The aim of this study is to evaluate device size selection in patients within the borderline annulus size range undergoing transcatheter aortic valve replacement (TAVR) and to assess if pre-procedural patient-specific computer simulation will lead to the selection of a different device size than standard of care.

Background
In TAVR, appropriate device sizing is imperative. In borderline annulus size cases no standardised technique for tailored device size selection is currently available. Pre-procedural patient-specific computer simulation can be used, predicting the risk for paravalvular leakage (PVL) and need for permanent pacemaker implantation (PPI).

Methods
In this multicentre retrospective study, 140 patients in the borderline annulus size range were included. Hereafter, device size selection was left to the discretion of the operator. After TAVR, in 24 of the 140 patients, patient-specific computer simulation calculated the most appropriate device size expected to give the lowest risk for PVL and need for PPI. In these 24 patients, device size selection based on patient-specific computer simulation was compared with standard-of-care device size selection relying on a standardised matrix (Medtronic).

Results
In a significant proportion of the 140 patients (26.4%) a different device size than recommended by the matrix was implanted. In 10 of the 24 patients (41.7%) in whom a computer simulation was performed, a different device size was recommended than by means of the matrix.

Conclusions
Device size selection in patients within the borderline annulus size range is still ambiguous. In these patients, patient-specific computer simulation is feasible and can contribute to a more tailored device size selection.
The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles
Authors: van der Pijl Robbert J. , Domenighetti Andrea A. , Sheikh Farah , Ehler Elisabeth , Ottenheijm Coen A. C. , Lange Stephan 
Published: September 2021

AbstractMuscle specific signaling has been shown to originate from myofilaments and their associated cellular structures, including the sarcomeres, costameres or the cardiac intercalated disc. Two signaling hubs that play important biomechanical roles for cardiac and/or skeletal muscle physiology are the N2B and N2A regions in the giant protein titin. Prominent proteins associated with these regions in titin are chaperones Hsp90 and αB-crystallin, members of the four-and-a-half LIM (FHL) and muscle ankyrin repeat protein (Ankrd) families, as well as thin filament-associated proteins, such as myopalladin. This review highlights biological roles and properties of the titin N2B and N2A regions in health and disease. Special emphasis is placed on functions of Ankrd and FHL proteins as mechanosensors that modulate muscle-specific signaling and muscle growth. This region of the sarcomere also emerged as a hotspot for the modulation of passive muscle mechanics through altered titin phosphorylation and splicing, as well as tethering mechanisms that link titin to the thin filament system.
Objectivity for the research worker
Authors: van Dongen Noah , Sikorski Michał 
Published: September 2021

AbstractIn the last decade, many problematic cases of scientific conduct have been diagnosed; some of which involve outright fraud (e.g., Stapel, 2012) others are more subtle (e.g., supposed evidence of extrasensory perception; Bem, 2011). These and similar problems can be interpreted as caused by lack of scientific objectivity. The current philosophical theories of objectivity do not provide scientists with conceptualizations that can be effectively put into practice in remedying these issues. We propose a novel way of thinking about objectivity for individual scientists; a negative and dynamic approach.We provide a philosophical conceptualization of objectivity that is informed by empirical research. In particular, it is our intention to take the first steps in providing an empirically and methodologically informed inventory of factors that impair the scientific practice. The inventory will be compiled into a negative conceptualization (i.e., what is not objective), which could in principle be used by individual scientists to assess (deviations from) objectivity of scientific practice. We propose a preliminary outline of a usable and testable instrument for indicating the objectivity of scientific practice.
The research on the operation mode and parameter selection method of large-scale water injection pipeline network
Authors: Ruan Yan , Liu Huan , Chen Jiaona 
Published: September 2021

AbstractDue to the complexity of the large-scale water injection pipe network system and the difficulty of manual analysis, it is impossible to guarantee the optimal operation mode scheme selected. At present, there are still gaps in the research on the judgment of its optimal operation mode. Through the calculation and evaluation of a large amount of water injection system data, the selection method of the optimal operation mode of the water injection system is determined, and it is found that the selection of the optimal operation mode is closely related to the pressure distribution characteristics of the individual wells of the entire water injection system, and five discriminant rules for the optimal operation mode of the water injection system are formed based on these characteristics; the mathematical model for determining the mode and the optimal method of operating parameters is given, and the pipeline network simulation system automatically generates the pipe network topology diagram; the optimal operation mode of the water injection system is developed; Intelligent judgment software can modify its operating parameters according to needs, change operating modes, easily simulate the energy consumption in various modes of operation, adjust and find the optimal operation plan of the water injection pipe network. Application examples show that the judgment rules of the optimal operation mode of the water injection system and the optimization method of operating parameters can be used as an effective means for selecting the optimal operation plan for a large-scale water injection pipeline network.
Risk-Layering for Indirect Effects
Authors: Hochrainer-Stigler Stefan , Reiter Karina 
Published: September 2021

AbstractEnvironmental risks are one of the greatest threats in the twenty-first century. Especially in the last years, the cascading impacts and risks associated with such events have received great attention as economic losses and consequences have mounted in their wake. As concerns about these ripple effects are rising, strategies to prevent and manage indirect risks are in urgent demand. However, such effects are currently barely considered in most countries and can seriously threaten global agendas such as achieving the Sustainable Development Goals by 2030 or the targets set out in the Sendai Framework for Disaster Risk Reduction 2015−2030. We discuss how the concept of risk-layering, which, though already applied in disaster risk management, could be expanded to include indirect effects. We point out some of the benefits, limitations, and ways forward for using this approach. To do so, we first delineate the transition of the risk-layering concept, which originated from the insurance industry, from its original use to its application in a wider context. We bring special focus to the application of risk-layering in disaster risk management and identify strategies that allow for the inclusion of indirect risks. Our main suggestion is that, while a probabilistic approach is appropriate for evaluating direct risks, a focus on connectedness is appropriate for indirect risks, which still allows for an easy link to direct risk-layering. This, so we argue, facilitates more comprehensive risk management systems apt to deal with the multi-dimensional challenges ahead.
An emergent infectious disease: Clostridioides difficile infection hospitalizations, 10-year trend in Sicily
Authors: Medaglia Alice Annalisa , Buffa Sergio , Gioè Claudia , Bonura Silvia , Rubino Raffaella , Iaria Chiara , Colomba Claudia , Cascio Antonio 
Published: September 2021

Abstract
Background
Clostridioides difficile is the most common cause of healthcare-associated diarrhoea worldwide and C. difficile infection is an emerging infectious disease. In the US, its rates are monitored trough an active surveillance system, but many European Union member states still lack this, and in Italy no epidemiological data on C. difficile infection are available except for a few single-centre data.

Aim
To provide data on the C. difficile infection incidence in Sicily (the biggest and 5th most populous region of Italy) during a 10-year period.

Methods
We revised all the regional standardized discharge forms between 2009 and June 2019 using the code ICD-9 00845 of the International Classification of Diseases, Ninth Revision Clinical Modification, which refers to C. difficile infection with or without complications.

Results
1139 cases of CDI were identified. 97% were adults with a median age of 73.2 years and a male-to-female ratio of 1:1.4. Female patients were older than males and patients who died were older than patients who did not. The main comorbidities were renal disease, diabetes, pneumonia and hypertension. There were 65 reporting hospitals and 86% of cases were provided by level III and II hospitals. Between 2009 and 2019, the incidence increased 40-fold. 81.5% of cases were reported in Medicine Units, Infectious Diseases Units and long-term care facilities. The mean length of stay was 20 days. Mean case fatality rate was 8.3% over the 10-year period.

Conclusion
Clostridioides difficile infection is a dramatically increasing condition in Sicily. A high-quality surveillance system and shared diagnostic protocols are needed.
Annette Leibing and Silke Schicktanz (eds): Preventing dementia?: Critical perspectives on a new paradigm of preparing for old age
Authors: Petersen Niklas , Perry Julia 
Published: September 2021

AbstractGiven the lack of effective curative treatment options and in light of a significant reconceptualization of Alzheimer’s disease, the focus of dementia research has shifted towards prevention, risk prediction, and detection in very early disease stages. In the context of these shifts, the edited volume Preventing Dementia?: Critical Perspectives on a New Paradigm of Preparing for Old Age (edited by Annette Leibing and Silke Schicktanz) collects critical and insightful positions on the new paradigm of dementia prevention from an interdisciplinary and international perspective. The editors introduce the overarching topic of prevention by reflecting on the optimistic framing of modifiable risk factors and their novelty in the dementia context. Leibing and Schicktanz call for a cautious reception of the findings in the Lancet report(s) and draw attention to epistemic, ethical, and socio-political issues of what the editors term the contested “new dementia” and to the effect that this might have on rethinking individual and societal perceptions of aging. The contributions of the anthology depict the social and cultural dimensions of dementia discourses and consider the ethical implications of the changing conceptions of Alzheimer’s disease as well as the shift towards early disease stages and prevention. With this, the anthology initiates a debate about the often implicit unresolved social, ethical, and political implications and preconditions of the medical understanding and handling of cognitive disorders.
Temperature-dependent device properties of γ-CuI and β-Ga2O3 heterojunctions
Authors: Venkata Krishna Rao Rama , Ranade Ajinkya K. , Desai Pradeep , Kalita Golap , Suzuki Hiroo , Hayashi Yasuhiko 
Published: September 2021

Abstract
Temperature-dependent studies of Ga2O3-based heterojunction devices are important in understanding its carrier transport mechanism, junction barrier potential, and stability at higher temperatures. In this study, we investigated the temperature-dependent device characteristics of the p-type γ-copper iodide (γ-CuI)/n-type β-gallium oxide (β‐Ga2O3) heterojunctions, thereby revealing their interface properties. The fabricated γ-CuI/β-Ga2O3 heterojunction showed excellent diode characteristics with a high rectification ratio and low reverse saturation current at 298 K in the presence of a large barrier height (0.632 eV). The temperature-dependent device characteristics were studied in the temperature range 273–473 K to investigate the heterojunction interface. With an increase in temperature, a gradual decrease in the ideality factor and an increase in the barrier height were observed, indicating barrier inhomogeneity at the heterojunction interface. Furthermore, the current–voltage measurement showed electrical hysteresis for the reverse saturation current, although it was not observed for the forward bias current. The presence of electrical hysteresis for the reverse saturation current and of the barrier inhomogeneity in the temperature-dependent characteristics indicates the presence of some level of interface states for the γ-CuI/β‐Ga2O3 heterojunction device. Thus, our study showed that the electrical hysteresis can be correlated with temperature-dependent electrical characteristics of the β‐Ga2O3-based heterojunction device, which signifies the presence of surface defects and interface states.

Article Highlights

We revealed the interface properties of p-type γ-copper iodide (γ-CuI) and n-type β-gallium oxide (β-Ga2O3) heterojunction.

The developed heterostructure showed a large barrier height (0.632 eV) at the interface, which is stable at a temperature as high as 473 K.

We confirmed the current transport mechanism at the interface of the heterojunction by analyzing the temperature dependent current–voltage characterization.

Graphic abstract
Improved prediction method for ground surface thawing settlement caused by the melting of tunnel horizontal frozen wall
Authors: Hong Rongbao , Cai Haibing , Li Mengkai 
Published: September 2021

AbstractWith the rapid development of urban subway tunnel, artificial ground freezing technology is becoming more and more mature. With the natural thawing of horizontal frozen wall, thawing settlement will occur on stratum due to the thawing of frozen soil and the consolidation of thawed soil, which will inevitably bring adverse impact on the surrounding environment of subway tunnel. Therefore, the establishment of a reasonable ground surface thawing settlement prediction method will provide a favorable theoretical support for predicting the ground surface deformation in advance and taking active thawing settlement control measures. In the paper, the time functions of ground surface thawing settlement and consolidation settlement of tunnel horizontal frozen wall are established based on the stochastic medium theory during natural thawing period, and the calculation methods of thawing front radius, inner radius of thawing shrinkage region and inner radius of consolidation region are proposed. The results show that the cumulative ground surface thawing settlement is larger than that of Cai et al. after considering the consolidation of the thawed soil, which fully indicates that the ground surface settlement caused by the drainage and consolidation of the thawed soil cannot be ignored. In addition, the thawing displacement rate of frozen soil is greater than the consolidation displacement rate of thawed soil during the natural thawing and the thawed soil will be consolidated at a lower settlement rate for a long time after the natural thawing period.
Examples of distorted interval diffeomorphisms of intermediate regularity
Authors: DINAMARCA LEONARDO , ESCAYOLA MAXIMILIANO 
Published: September 2021

AbstractWe improve a recent construction of Andrés Navas to produce the first examples of
$C^2$
-undistorted diffeomorphisms of the interval that are
$C^{1+\alpha }$
-distorted (for every
${\alpha < 1}$
). We do this via explicit computations due to the failure of an extension to class
$C^{1+\alpha }$
of a classical lemma related to the work of Nancy Kopell.
Crisis, Rhetoric and Right-Wing Populist Incumbency: An Analysis of Donald Trump's Tweets and Press Briefings
Authors: Lacatus Corina , Meibauer Gustav 
Published: September 2021

AbstractHow do right-wing-populist incumbents navigate rhetorical strategic choices when they seek to manage external crises? Relevant literature has paid increasing attention to the role of ‘crisis’ in boosting the electoral success of right-wing populist candidates. We know a lot less about the rhetorical strategies used by right-wing populist incumbents seeking re-election. We draw on literatures on populism, crisis management and political rhetoric to conceptualize the rhetorical strategic choices of right-wing populist incumbents in times of crisis. We propose a framework for the choice of rhetorical strategy available to right-wing populist incumbents and illustrate it with a qualitative content analysis of Trump's tweets and White House press briefings during the first months of the COVID-19 pandemic. We find limited rhetorical adaptation to crisis and high degrees of continuity with previous rhetoric grounded in right-wing populism. This challenges prevalent assumptions regarding the likelihood of incumbent rhetorical flexibility in the face of crisis.