bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time Series Analysis of Price of Coffee in Case of Mettu Town, Ilu Ababor Zone, Oromia Regional State, Ethiopia
Authors: Ababu Dereje Gebeyehu , Getahun Azmeraw Misganaw 
Published: July 2021

Background: Coffee is one of the most important cash crops across the world and major source of export earnings. Coffee has been and remains the leading cash crop and export commodity of Ethiopia. The aim of this study was to estimate and predict the price change of coffee in Mettu town. Methods: In this study both descriptive and inferential statistics were used to analyze secondary data that were collected from Mettu town of Ethiopian Commodity Exchange office sector. A total of 120 months of price of coffee was included in this study. Time series analysis was used to estimate the parameter and for forecast the future values of price change of coffee. Result: The original data was not stationary and become stationary after second order differencing. The results showed that the price change of coffee was increasing from time to time. After that the data tested the order MA and AR are identified by using the ACF and PACF. Then the model was selected by using AIC. Since, ARMA (1, 2, 1) for price change of coffee was lower values of AIC found to be the most appropriate model to fit the data of the price change of coffee. After the model was fitted, the diagnostic checking has been applied by using the ACF residual and normality checking. So that the model fitted is appropriate for the price change of coffee. All the forecast values are found between the lower and the upper interval then we can say that forecasted value is accurate.
Growth of Legume Cover Crops under Cassava and Its Effect on Soil Properties
Authors: . Suwarto , Asih Retno 
Published: July 2021

Background: Low soil organic carbon is a constraint to cassava tuber formation. Some legume cover crops could be an alternative to provide organic matter on the cassava field as a source of soil organic carbon. The study was aimed to evaluate the growth of some legume cover crops under cassava and their effects on soil properties. Methods: During September 2017-July 2018 legume cover crops (Calopogonium mucunoides, Centrosema pubescens, Pueraria javanica and the mixed) were planted under cassava variety of Mangu and UJ-5. The land coverage by the legume cover crops was measured monthly from 2 to 10 months after planting. Cassava growth was observed weekly from 8 to 32 weeks after planting. Soil properties were analyzed before planting and at harvesting of cassava. Result: Pueraria javanica was tolerant toward cassava shading. The land coverage was linearly increased along with the growth of cassava. At the end of cassava growth, the land area coverage by this legume cover crop was 98.08%. It produced more organic matter and could maintain soil moisture content than other legume cover crops. P. javanica could consider being a suitable legume cover crop under cassava to improve soil quality.
Media literacy at the county councils of experts in Croatia: The perspective of senior advisors for primary education
Authors: Vanek Katarina 
Published: July 2021

The aim of this paper is to gain an insight into the professional development of Croatian primary education teachers when it comes to informing about media literacy at their County Councils of Experts (CCE) from the perspective of senior advisors for primary education. Five senior advisors were interviewed, and they pointed out that media literacy has sometimes been the topic at the councils, but they consider that it should be more often discussed. The results show that Croatian teachers mostly get information about the theoretical background and present examples of good practice. There are a lot of improvements which might be carried out to encourage media literacy. The results suggest anticipating greater importance to media literacy and the recognition of its importance by the Croatian authorities. Croatian primary education teachers are poorly informed about media literacy at their CCE. These results can be a starting point for further research.

Keywords: Councils of experts, media literacy, primary teachers, senior advisors, professional development.
Clinical and Economic Aspects of Tuberculosis Detection During Mass Fluorographic Examinations of the Population
Authors: Markelov Yu. M. , Shchegоleva L. V. 
Published: July 2021

Objective: to study the clinical and economic efficiency of mass fluorographic examinations of the population for tuberculosis (TB).Subjects and methods. The study used the data of fluorographic examinations for TB among 2,632,169 people and in its risk groups (n = 44,597) in the Republic of Karelia in 2008–2018.Results. It was found that the increased efficiency of detection of TB could not reduce its one-year mortality in firstly identified patients. The average cost of detecting one TB case during mass examinations was more than 500,000 rubles for this period.Conclusion. Mass fluorographic examinations of the population cannot reduce TB mortality rates and are extremely expensive. To lower the mortality rate and to improve the detection of TB, there is a need for screening high-risk groups for this disease at least once every 6 months.
Malignant Phyllodes Tumor by the Example of a Clinical Case
Authors: Korzhenkova G. P. , Kasymova A. A. 
Published: July 2021

Breast cancer is the most common cancer in women worldwide, but there are also rarer types of breast neoplasms in clinical practice. One of these neoplasms is a phyllodes tumor. Due to the rare occurrence of phyllodes tumors and few studies of this pathology, there is today no information about the precise etiology and pathogenesis of this tumor. For the same reasons, it is very difficult to correctly and timely diagnose breast cancer, which requires both a highly qualified radiologist who first detects this disease in a patient and a pathologist who establishes a final morphological diagnosis. Existing studies, such as mammography and ultrasound, do not have reliable criteria for the diagnosis of phyllodes tumors and are unable to differentiate different histological types of these neoplasms, which further complicates the diagnosis of this pathology. Also, standards for the treatment of patients with this diagnosis have not been fully approved. The paper describes a clinical case of successful surgical treatment for a malignant phyllodes tumor of the left breast in a 47-year-old patient.
CT Diagnosis of Complications Arising from the Natural History and Treatment of COVID-19
Authors: Yadrentseva S. V. , Nudnov N. V. , Gasymov E. G. , Pron’kina E. V. 
Published: July 2021

Computed tomography for coronavirus infection (COVID-19) is effective not only in making a diagnosis, but also in timely and accurately detecting some complications of this disease in different organs and systems. The paper shows various complications of coronavirus infection that a radiologist may face in practice, which develop both in the natural course and due to therapy for COVID-19, including hemorrhagic and thrombotic events in coagulopathy, pneumothorax, and pneumomediastinum as a result of the direct cytotoxic effect of SARS-CoV-2 on pneumocytes, and barotrauma during mechanical ventilation, as well as pathological fractures due to osteoporosis, including steroid osteoporosis that has developed during therapy with glucocorticosteroids. It considers the main causes and pathogenesis of various complications of coronavirus infection.
Stress Shielding in the Setting of Osteogenesis Imperfecta and the Effect of Downsizing an Intramedullary Rod
Authors: Franzone Jeanne M. , Sargent Brandi M. , Dang Do An N. , Knue Marianne , Marini Joan C. , Kruse Richard W. 
Published: July 2021

Case:
Cortical atrophy, or stress shielding, secondary to a large-diameter femoral intramedullary rod was noted over almost a decade in a now 14-year-old girl with osteogenesis imperfecta (OI). After an initial minimally invasive unsuccessful revision, we downsized the left femur rod with realignment and noted restoration of the left femur cortical thickness.

Conclusion:
We demonstrate the significant functional impact of stress shielding and its evolution over a protracted period and outline treatment principles. To our knowledge, this is the first report of treatment of stress shielding of a long bone in the setting of OI.
Distal Femoral Arthroplasty Versus Open Reduction Internal Fixation for Comminuted Osteoporotic Supracondylar Distal Femur Fractures
Authors: Smith Paula Michelle , Johnson Eric T. 
Published: July 2021

Purpose:
The purpose of the article is to review the treatment of comminuted distal femur fractures and examine the risks and benefits of distal femoral replacement/arthroplasty (DFA) for the treatment of complicated osteopenic supracondylar femur fractures.

Method:
An OVID MEDLINE, PubMed, and Cochrane Database of Systematic Reviews literature search was conducted with search terms distal femur fracture, distal femoral replacement, osteoporosis, fixation, and functional outcomes. Forty-six articles pertinent to the topic were retrieved. These articles serve as the basis for the clinical review portion of the article. A patient representing the clinical question was selected for inclusion in the case study. Verbal consent was obtained, consistent with the guidelines from the Journal of Orthopaedics for Physician Assistants.

Results:
There is a paucity of evidence-based literature to justify the use of distal femoral replacement/DFA for the management of comminuted supracondylar distal femur fractures. Further study is needed to document the role of DFA for frail, elderly patients.

Conclusion:
Open reduction internal fixation has been used to treat distal femur fractures. The techniques of locked plating (with or without variable angle construct), percutaneous fixation, and intramedullary nailing are well established for the treatment of fractures of the distal femur. The use of distal femoral replacement/DFA has been shown to decrease weight-bearing limitations, decrease immobility, minimize the use of a brace, and maximize function after complicated fractures with osteoporosis. Further research is needed to identify the role of DFA for the treatment of comminuted distal femur fractures in the elderly population.
Augmented Reality-Assisted Femoral Bone Resection in Total Knee Arthroplasty
Authors: Tsukada Sachiyuki , Ogawa Hiroyuki , Nishino Masahiro , Kurosaka Kenji , Hirasawa Naoyuki 
Published: July 2021

Background:
An augmented reality (AR)-based navigation system allows visualization of the center of the femoral head and femoral mechanical axis superimposed on the surgical field during total knee arthroplasty (TKA) and may help surgeons to improve the accuracy of distal femoral resection.

Methods:
First, we resected 10 femoral Sawbones specimens using the AR-based navigation system and performed computed tomography (CT) to measure the resection angle of the distal part of the femur. We calculated the absolute values of the differences between angles measured using CT images and angles displayed on the smartphone screen of the navigation system. Second, we measured coronal alignment using standing long-leg radiographs for 72 patients undergoing TKA and compared the error in the resection angle between TKA using the AR-based navigation system and that using a conventional intramedullary guide.

Results:
In the experimental study, the absolute values of the differences between angles measured on CT images and angles displayed using the AR-based navigation system were 0.8° ± 0.5° (range, 0.3° to 1.9°) in the coronal plane and 0.6° ± 0.5° (range, 0.0° to 1.4°) in the sagittal plane. In the clinical study, the mean absolute value of the error in coronal alignment was significantly smaller in the AR-based navigation group than the intramedullary-guide group (1.1° ± 1.0° [range, 0.0° to 3.2°] compared with 2.2° ± 1.6° [range, 0.0° to 5.5°], respectively; 95% confidence interval, 0.5° to 1.8°; p < 0.001).

Conclusions:
The AR-based navigation system may enable surgeons to perform distal femoral resection more accurately than with the conventional intramedullary guide during TKA.

Clinical Relevance:
This study validates the use of AR technology to enhance the precision of bone resection in TKA.
Meta-QTLs, Ortho-metaQTLs and Candidate Genes for Grain Yield and Associated Traits in Wheat (Triticum Aestivum L.)
Authors: Saini Dinesh Kumar , Srivast Puja , Pal Neeraj , Gupta P. K. 
Published: July 2021

Abstract
Meta-QTL analysis was conducted using 8,998 known QTLs, which included 2,852 major QTLs for grain yield (GY) and its following ten component/related traits: (i) grain weight (GWei), (ii) grain morphology related traits (GMRTs), (iii) grain number (GN), (iv) spikes related traits (SRTs), (v) plant height (PH), (vi) tiller number (TN), (vii) harvest index (HI), (viii) biomass yield (BY), (ix) days to heading/flowering and maturity (DTH/F/M) and (x) grain filling duration (GFD). The QTLs used for this study were retrieved from 230 reports (including 19 studies conducted in tetraploid wheat) that were based on 190 mapping populations (1999–2020). The study resulted in the identification of 141 meta-QTLs (MQTLs), with an average confidence interval (CI) of 1.37 cM (reduced 8.87 fold), the average CI in the initial QTLs being > 12.15 cM. As many as 63 MQTLs, each based on at least 10 initial QTLs were stable and robust; with 13 MQTLs are described as breeder’s QTLs. MQTLs were also utilized for the identification of 1,202 candidate genes (CGs), which included 18 known genes. The MQTLs were also found to contain 50 wheat genes that were homologous to 35 known yield-related genes from rice, barley, and maize. Further, the use of synteny and collinearity allowed the identification of 24 ortho-MQTLs which were common among the wheat, barley, rice, and maize. The results of the present study should prove useful for wheat breeding and future basic research in cereals including wheat, barley, rice, and maize. In particular, the breeder’s QTLs can be used for marker-assisted selection for grain yield and fine mapping leading to cloning of QTLs/genes for yield and related traits.
Symptomatic DVT One Month After TKA Was Associated With Tourniquet Reuse During Operation
Authors: Shen Jing , Pan Zhicheng , Liu Wangxin , Tian Yuan , Ji Weifeng 
Published: July 2021

Abstract
Background: DVT (Deep vein thrombosis) was one of the most common and sever complications after TKA (total knee arthroplasty). When tourniquet use and sometime the reuse was performed for surgery convenient of TKA. There was not sure if tourniquet use or reuse during operation would increase DVT after TKA.Methods: A retrospective study was performed about primarily TKA in our institute continuous 5 years. Univariate analysis was performed and potential intervention variables (P ≤ 0.1) were included in multiple factor analysis to certain the independent risk factors.Results: 807 patients (431 females and 376 males) were included with mean age was 65 years old. 3.84% (31 patients) were occurred sym-DVT (symptomatic DVT) one month after TKA with median time of diagnosis was 17 days. Incidence of sym-DVT after tourniquet reuse was significant high than once use and no use (7.25% versus 2.54% and 1.86%, P = 0.014 and 0.072), mean time of tourniquet use was 90.46 ± 14.28 mins in once and 106.58 ± 16.13 mins in reuse (P = 0.045). After multiple analysis, independent risk factors were revealed as history of tumor (P = 0.021), history of DVT (P < 0.001) and tourniquet reuse (P = 0.005).Conclusions: Tourniquet reuse was associated with highly incidence of sym-DVT other than history of tumor and DVT. There should be once use of tourniquet for prevent sym-DVT.
Effects of Water Particles in the Jinjiang River Estuary on the Physiological and Biochemical Characteristics of Microcystit Flos-Aquae
Authors: Nan Yiting , Guo Peiyong , Xing Hui , Chen Sijia , Hu Bo , Liu Jie 
Published: July 2021

Abstract
The effects of different concentrations (100,150,200,250 mg/L) and different particle sizes (0–75µm, 75–120µm, 120–150µm, 150–500µm) on soluble protein content, SOD and CAT activity, MDA content, chlorophyll a content and photosynthetic parameters of Microcystis flos-aquae were studied, the mechanism of the effect of suspended particulate matter on the physiology and biochemistry of Microcystis flos-aquae was discussed. The results showed that the soluble protein content of Microcystis flos-aquae did not change obviously after being stressed by suspended particles of different concentration/diameter. The SOD activity of Microcystis flos-aquae increased at first and then decreased with the increase of the concentration of suspended particulate matter. The SOD activity of Microcystis flos-aquae reached 28.03 U/mL when the concentration of suspended particulate matter was 100 mg/L. The CAT activity of Microcystis flos-aquae increased with the increase of the concentration of suspended particles, and reached the maximum value of 12.45 U/mgprot in the concentration group of 250 mg/L, showing a certain dose-effect. The effect of small particle size on SOD, CAT and MDA of Microcystis flos-aquae was more significant than that of large particle size. The larger the concentration and the smaller the particle size, the stronger the attenuation of light and the lower the content of chlorophyll a. Both Fv/Fm and Fv/F0 of Microcystis flos-aquae increased at first and then decreased under different concentration/size of suspended particles. The relative electron transfer rate gradually returned to the normal level with the passage of time. There was no significant difference in α value between treatment group and control group, ETRmax and Ik decreased.
Health Risk Assessment of Heavy Metals Through the Consumption of Vegetables in the National Capital Region, India
Authors: Rani Jyoti , Agarwal Tripti , Chaudhary Sudesh 
Published: July 2021

Abstract
This study aimed to evaluate the heavy metal contamination in the vegetables growing in the national capital region of India and to assess the health risk in human resulting from consumption of these vegetables. A total of 99 vegetable samples were collected from the selected study area during the winter season and were analyzed for heavy metals contamination by atomic absorption spectrophotometer. The relative abundance of heavy metal in the vegetable samples was in the following order: Fe > Al > Mn > Zn > Cu > Cr > Ni > Pb > Cd > Co. The mean concentration of Al, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, and Zn, in the vegetables was 158.01 mg kg− 1dw − 1, 0.23 mg kg− 1 dw− 1, 0.04 mg kg− 1 dw− 1, 3.70 mg kg− 1 dw− 1 7.82 mg kg− 1 dw− 1, 297.87 mg kg− 1 dw− 1, 39.81 mg kg− 1 dw− 1, 1.78 mg kg− 1 dw− 1, 0.52 mg kg− 1 dw− 1, and 32.21 mg kg− 1 dw− 1 for respectively. The statistical analysis supported the formation of two primary clusters Al-Fe-Pb and Cu-Zn, indicating their common source of origin. Most of the vegetable samples exceeded the permissible limit of heavy metals prescribed by the Food and agricultural organization/ World health organization (FAO/WHO) standards. The total target hazard quotient was greater than 1 for all types of vegetables, indicating appreciable health risk due to the consumption of these vegetables in the study area.
The Expression Discrepancy And Characteristics of Long Non-Coding RNAs In Peripheral Blood Leukocytes From Amyotrophic Lateral Sclerosis Patients
Authors: Yu Yujiao , Pang Dejiang , Li Chunyu , Gu Xiaojing , Chen Yongping , Ou Ruwei , Wei Qianqian , Shang Huifang 
Published: July 2021

Abstract
Amyotrophic lateral sclerosis (ALS) is known to be a progressive neurodegenerative disease that affects upper and lower motor neurons. Less than 10% of ALS patients are defined as familial ALS, more than 90% are sporadic ALS (SALS). According to the genomic information described in existing databases, up to 98% of the human genome consists of non-coding sequences. Nearly 40% of long non-coding RNAs (lncRNAs) are specifically expressed in the brain. We believe that the discrepancy of lncRNAs expression plays a key role in neurodegenerative diseases. We screened 30 lncRNAs with altered expression from peripheral blood leukocytes of SALS patients by microarray and validated 13 of them in leukocytes of SALS, Parkinson's disease (PD) patients and healthy controls (HC). We followed the bioinformatics to perform a functional enrichment analysis of co-expressed mRNAs, transcription factors and lncRNAs for functional prediction. We identified lnc-DYRYK2-7:1, lnc-ABCA12-3:1 and lnc-POTEM-4:7 show decreased expression in SALS patients, whereas in PD patients they show increased expression or no change. In addition, expression of lnc-CNTN4-2:1 and lnc-NR3C2-8:1 were decreased in both SALS and PD patients. We found that XIST was only reduced in male patients with SALS and PD, and not in female patients with SALS but was elevated in PD by gender grouping. We also performed GO term enrichment and KEGG pathway analysis for lncRNAs showing differential expression in microarray. We discovered that a significant proportion of differential expressed lncRNAs were associated with various signaling pathways and transcription factors which are consistent with other clinical findings.
Bilateral Intracapsular Hip Fracture in a Patient With Low Functional Demand Treated With a One-stage Bilateral Hemiarthroplasties. A Case Report and Literature Review.
Authors: Latorre Marcos Raul , Buljubasich Martin , Mansilla Agustín María Garcia , Slullitel Pablo Ariel Isidoro , Zanotti Gerardo , Comba Fernando Martin , Piccaluga Francisco , Buttaro Martín Alejandro 
Published: July 2021

Abstract
Bilateral femoral neck fracture is a rare injury. While they may be of traumatic origin, they are generally associated with some underlying condition that predisposes to this pathology, such as neurological disorders or bone metabolism diseases. We present an 83-year-old woman with severe osteoporosis who had a simultaneous bilateral intracapsular hip fracture.
Tissue Accumulation of Neutrophil Extracellular Traps Mediates Muscle Hyperalgesia in a Mouse Model
Authors: Suzuki Kazuaki , Tsuchiya Masahiro , Yoshida Shinichiro , Ogawa Kazumi , Chen Weijian , Kanzaki Makoto , Takahashi Tadahisa , Fujita Ryo , Li Yuqing , Yabe Yutaka , Aizawa Toshimi , Hagiwara Yoshihiro 
Published: July 2021

Abstract
Accumulation of uric acid (UA) during muscular trauma is a causative factor involved in the development of muscle hyperalgesia. Neutrophil extracellular traps (NETs), DNA-based reticular structures to capture UA, play a central role in the pain onset of gout attacks; however, the involvement of NETs via the elevation of local UA level in muscle hyperalgesia due to overuse injuries remains unknown. The triceps surae muscles (TSMs) in the unilateral hindlimb of mice were electrically stimulated to induce excessive muscle contraction. Mechanical withdrawal thresholds, tissue UA levels, neutrophil recruitment, protein amount of citrullinated histone 3 (citH3), a major marker of NETs, were investigated. Furthermore, whether neutrophil depletion, extracellular DNA cleavage, and administration of the urate-lowering agent febuxostat could improve muscle hyperalgesia due to NET formation was examined. CitH3 expression upon neutrophil recruitment significantly increased in the stimulated TSMs with an increase in tissue UA levels, whereas febuxostat administration improved muscle hyperalgesia with decreases in citH3 and tissue UA levels, as observed in neutrophil depletion and extracellular DNA digestion. The underlying mechanism of muscle hyperalgesia associated with locally recruited neutrophils forming NETs due to the increased tissue UA levels potentially plays a significant role in creating a vicious circle of muscle pain.