bluuebunny/crossref_metadata_2025_split huggingface dataset:
FEATURES OF THE DYNAMICS OF THE II DEGREE OF SEVERETY BACTERIAL KERATITES IN DIABETIC PATIENTS AT DIFFERENT STAGES OF DIABETIC POLYNEYROPATHY
Authors: Zavoloka O. V. 
Published: October 2021

Summary. The neuro-trophic condition of the cornea affects the healing process of corneal defects in patients with keratitis, causing the severity, duration and consequences of the disease.
The aim was to identify the features of the dynamics of the II degree of severity bacterial keratitis in patients with diabetes mellitus (DM) at different stages of the severity of diabetic polyneuropathy (DPN).
Materials and methods. The results of treatment of 19 patients with bacterial keratitis of the II degree of severity and type 1 DM were analyzed. II degree of severity of bacterial keratitis was determined according to our proposed scheme at a sum of points 15-21. All patients were treated with instillations of the antibiotic ofloxacin, antiseptics, antioxidants, reparants, artificial tears, mydriatics, systemic anti-inflammatory therapy. Patients were divided into two groups according to the severity of DPN: with symptomatic (first group) and stage with impaired DPN (second group). In addition to standard, ophthalmic examination methods included bacteriological examination, fluorescein test, OCT of the anterior segment of the eye, non-contact corneal esthesiometry.
Results and discussion. In most patients of the second group, corneal sensitivity and depth of edema of the corneal tissues surrounding the ulcer, the size of the ulcer defect and the depth of corneal infiltration, the degree of pericorneal injection, the depth of the corneal ulcer defect from the 1st, 7th, 10th and 14th days of observation, respectively, were higher than in patients of the first group (p<0,05). The consequence of the disease in patients of the second group was more severe than in patients of the first group.
Conclusions. In patients with the stage of impaired DPN, bacterial keratitis is characterized by a longer duration and severity of clinical symptoms, as well as worse consequences of the disease than in patients with symptomatic DPN.
NEW PROSPECTS OF DIAGNOSIS IN EMERGENCY ABDOMINAL SURGERY
Authors: Shurma A. I. , Grinchuk F. V. , Motric A. V. 
Published: October 2021

Summary. Aim. Search for new methods for diagnosing acute surgical pathology of the abdominal cavity (ASPAC).
Materials and methods. 39 patients: liver abscess — 4, acute appendicitis, periapendicular abscess — 3, acute appendicitis, perito-nitis — 5, acute phlegmonous appendicitis — 7, acute phlegmonous cholecystitis — 4, colon perforation, peritonitis — 3 , acute uncomplicated adhesive intestinal obstruction — 4, uncomplicated peptic ulcer — 4. Measured the optical density of venous blood plasma on a spectrophotometer SF-4A. The control was given to 8 patients (adhesive intestinal obstruction, uncomplicated peptic ulcer disease).
Results and discussion. A number of maxima of the values of the optical density of the plasma at wavelengths λ = 3.1, 3.5, 4.3, 6.1, 6.7, 9, 17.5 micrometers were revealed. Indicators differed depending on the type of underlying disease and complications. For analysis and comparison, patients were divided into groups: abscesses, peritonitis, destructive pathology without peritonitis (appendicitis, cholecystitis) and control. At wavelengths λ = 3.1, 6.1, 6.7, 9, 17.5 micrometers, the optical density in patients with no destructive pathology is significantly lower than in patients with such pathology. In addition, the indicators differ in the presence of peritonitis, abscesses and uncomplicated destructive pathology.
Conclusions. In the presence of acute surgical diseases of the abdominal cavity in patients, the specific maxima of the optical density of venous blood plasma in the infrared region at wavelengths λ = 3.1, 3.5, 4.3, 6.1, 6.7, 9, 17 , 5 micrometers. Changes in the parameters of optical density differ, depending on the characteristics of the underlying disease and complications and have common patterns in the perforation of hollow organs, abscesses, peritonitis, destructive uncomplicated diseases. Determination of optical density is a promising area for improving the diagnosis of ASPAC.
MAIN FACTORS OF DECOMPENSATION SYSTEM I NFLAMMATORY REACTION SYNDROME THE PATIENTS WITH ABDOMINAL SEPSIS
Authors: Shapovaliuk V. V. 
Published: October 2021

Summary. The goal of the robot is to determine the factors of decompensation of the systemic inflammatory response syndrome (SIRS) in abdominal sepsis (AS). Materials and methods. Based on the results of a comprehensive examination of 295 patients with AS according to the indicators of clinical and laboratory, biochemical, immunological examination and study of intra-abdominal pressure and the severity of enteral insufficiency, the leading factors in the development of DSIRS were determined.
Results and discussion. It was found that against the background of secondary cellular immunodeficiency, the development of severe compartment syndrome with decompensated enteric insufficiency syndrome (EIS) was determined, which in combination deepened pathological changes with the progression of the inflammatory reaction and the development of organ failure. Indicators of the level of C-reactive protein 2.5 times, and procalcitonin 2.4 times were higher during hospitalization of patients with decompensated syndrome (P<0.001). With decompensation, a severe degree of SES was diagnosed 18.5 times more often, and with a compensated one, a mild degree of insufficiency was diagnosed 57 times more often, P <0.001. At the same time, a direct correlation was determined between the severe degree of EIS and symptoms of nausea (r = 0.420), vomiting (r = 0.573) and bloating (r = 0.251), (P <0.005). The immunoregulatory index (IRI) played the role of a marker of decompensation in patients with AS, (r = + 0.74, at p <0.01) with the development of secondary immunodeficiency, according to the T-suppressor type. In 60.8 % (n = 101) of cases with DSIRS, the fourth degree of intra-abdominal pressure was determined, on average it was (46.3 ± 6.3) mm, and I degree was determined only in the case of compensation, (P <0.001). More often in patients with DSIRS, the associations of gram-positive microorganisms and enterococci were determined — in 55.6 % and streptococci — in 38.1 % of cases. At the same time, in 81.3 % of cases, patients with DSIRS were diagnosed with aerobic-anaerobic mixed flora.
Сonclusion. The obtained results of the study require the development of treatment methods that will effectively correct these pathogenetic changes in all directions in patients with AS.
THE I NFLUENCE OF INTRАDIАLYTIC HYPOTENSION ON THE FUNCTIONING OF АRTERIOVENOUSFISTULА
Authors: Nykonenko A. O. , Vildanov S. R. 
Published: October 2021

Introduction. Nowadays hemodialysis is the most widespread way of treatment concerning the end-stage renal disease. The variant of choice as for permanent vascular access for hemodialysis is arteriovenous fistula. An actual problem is the deterioration of the patency of arteriovenous fistula. According to the research, most patients do not know about the risks associated with intradialytic hypotension. Under these conditions, research with determining the level of critical intradialytic hypotension is particularly relevant.
Purpose of the work is to study and evaluate intradialytic hypotension as a risk factor for thrombosis of arteriovenous fistulas.
Materials and methods. 60 patients were examined with end-stage renal disease, receiving of hemodialysis. Among these patients a thrombosis of arteriovenous fistula appeared in the long term (7.5 (3.0–17.6) months) after the surgery. The average age of patients was (54.1 ± 11.8) years; there were 30 (50%) men, 30 (50%) women.
Results. According to the results of our study, 38 (63 %) patients had hypotension at the end of the hemodialysis session.
Conclusions. Blood hypotension is one of the main predictors of thrombosis of arteriovenous fistula in the late postoperative period. A decrease in systolic blood pressure on 35.0 (25.0–50.0) mm Hg to 100.0 (90.0–110.0) mm Hg is critical for the patency of arteriovenous fistula. Adequate control and correction of blood pressure (in particular, during a hemodialysis session) can prevent thrombosis of arteriovenous fistula.
PROLONGED IMMUNE-INFLAMMATORY REACTIONS IN PATIENTS WITH COVID-19- ASSOCIATED SURGICAL PATHOLOGY IN THE POSTCOVID PERIOD
Authors: Klimova E. M. , Kalashnikova Yu. V. , Drozdova L. A. , Merezhko O. S. , Lavinskaya E. V. , Sydorjak A. V. 
Published: October 2021

Summary. Introduction. The combination of pathogenetic factors of the main surgical pathology, multiple organ dysfunction, acute respiratory distress syndrome and cytokine storm against the background of SARS-Cov-2 infection justifies the relevance of this study.
Materials and methods. We examined 13 patients with acute COVID-19 and 29 patients with SARS-Cov-2-associated urgent surgical pathology. Investigated the concentration of C-reactive protein (CRP) by latex agglutination, C3 and C4 components of the complement by immunoturbidimetry, the content of interleukins IL-6 and IL-18 by ELISA, determination of autoantibodies by luminescence microscopy.
Results. In patients with SARS-Cov-2-associated urgent surgical pathology, certain patterns of changes in the markers under study were revealed: in all examined groups of patients, an increased concentration of C-reactive protein was observed, which indicated a systemic inflammatory response both in the acute and in the postcovid period. In the postcovid period of viral infection, the most significant are the high frequency of the maximum increase in the concentration of CRP, C3- and C4-complement components, and a significant or moderate increase in the content of interleukins IL-6 and IL-18, more pronounced than in the acute period of infection. The maximum increase in pro-inflammatory cytokines was found in patients with abdominal surgical pathology against the background of COVID-19 (postcoid period), while in the acute period of COVID-19, an increase in the concentration of IL-6 had no diagnostic value. A cytokine storm was detected in 20.5% of the examined patients with COVID-19-associated urgent surgical pathology.
Conclusions. For COVID-19-associated surgical pathology, the formation of autoimmune conditions is characteristic, which is expressed in the presence of a wide range of autoantibodies to nuclear structures. Thus, for the prevention and complex treatment of COVID-19-associated urgent surgical pathology, it is advisable to use personified step-by-step immunotropic therapy.
MECHANISMS OF IMMUNOCORRECTIVE ACTION OF PHOTODYNAMIC THERAPY AND EXOSOMES OF MESENCHYMAL STEM CELLS IN PATIENTS WITH CHRONIC WOUNDS OF THE LOWER EXTREMITIES OF DIFFERENT GENESIS
Authors: Klimova O. M. , Ivanova Yu. V. , Bychenko K. A. , Merezhko O. S. , Prasol V. O. , Lobintseva G. S. 
Published: October 2021

Summary. Introduction. The treaonic wounds of the lower extremities today requires long-term use of antibiotic therapy, which aggravates the course of the wound process. In this regard, the search for new methods of treatment is underway. Low-intensity light exposure of various wavelengths of photodynamic therapy with photosensitizer photosensitizer Dimegin was used as a physical method, and multipotent mesenchymal-stromal cells and their exometabolites in exosomes form were used as a biological method.
The aim was to study the change of barrier function of oxygen-independent and oxygen-dependent phagocytosis and serum levels of vascular growth factor (VEGF) in patients with chronic wounds of the lower extremities before and after the application of complex light exposure and exosomes.
Materials and methods. Phagocytosis activity of neutrophils was investigated by assessing chemotaxis, adhesion and endocytosis and by determining reactive oxygen species (ROS) in oxygen-dependent phagocytosis using light and confocal microscopy. VEGF concentration was determined by ELISA.
Results: after photodynamic therapy using with red light (λ=660nm), activation of oxygen-independent and oxygen-dependent phagocytosis was observed, as well as an increase in the synthesis of vascular growth factor in patients with chronic wounds of the lower extremities. After the application of green light (λ=530nm) and the application of exosomes, the normalization of immune processes was observed, which led to the acceleration of regenerative processes in the wound.
Conclusions. Thus, after carrying out complex low-intensity light therapy and exosomes, it was possible to completely clear the wounds from necrosis in a short time.
CLINICAL EFFICIENCY OF OPEN AND ENDOSCOPIC INTERVENTIONS WITH OBSTACLES OF THE TERMINAL DEPARTMENT OF CHOLEDOCH IN PATIENTS WITH GALLSTONE DISEASE OF ELDERLY AND SENILE AGE
Authors: Riazanov D. , Mikheiev Yu. , Shpylenko O. 
Published: October 2021

Summary. Purpose. To optimize the tactics of endoscopic interventions for cholelithiasis complicated by obstruction of the terminal portion of the common bile duct to reduce the incidence of postoperative complications and mortality in elderly and senile people.
Materials and methods. The results of examination and treatment of 221 elderly and senile patients with cholelithiasis complicated by obstruction of the terminal section of the common bile duct were analyzed.
Results. Using of existing methods and proposed new methods of endoscopic management of cholelithiasis complicated by obstruction of the terminal section of the common bile duct allow to reliably reduce the incidence of postoperative complications in elderly and senile patients from 19.8 to 9.5%, postoperative mortality from 10.3 to 2.9%
Conclusions. In elderly and senile patients with obstruction of the terminal section of the common bile duct and common bile duct stones who bear high operational risk, endoscopic papillosphincterotomy with stone removal is a sufficient method of treatment. In case of unremovable common bile duct stones, endoscopic papillosphincterotomy and stenting allow to avoid revision of the common bile duct, and in high-risk patients those methods allow to refrain from open surgery.
A Decade of SCUBA-2: A Comprehensive Guide to Calibrating 450 μm and 850 μm Continuum Data at the JCMT
Authors: Mairs Steve , Dempsey Jessica T. , Bell Graham S. , Parsons Harriet , Currie Malcolm J. , Friberg Per , Jiang Xue-Jian , Tetarenko Alexandra J. , Bintley Dan , Cookson Jamie , Li Shaoliang , Rawlings Mark G. , Wouterloot Jan , Berry David , Graves Sarah , Mizuno Izumi , Acohido Alexis Ann , Clark Alyssa , Cox Jeff , Fuchs Miriam , Hoge James , Kemp Johnathon , Lee E’lisa , Matulonis Callie , Montgomerie William , Silva Kevin , Smith Patrice 
Published: October 2021

Abstract
The Submillimetre Common User Bolometer Array 2 (SCUBA-2) is the James Clerk Maxwell Telescope’s continuum imager, operating simultaneously at 450 and 850 μm. SCUBA-2 was commissioned in 2009–2011, and since that time, regular observations of point-like standard sources have been performed whenever the instrument is in use. Expanding the calibrator observation sample by an order of magnitude compared to previous work, in this paper we derive updated opacity relations at each wavelength for a new atmospheric extinction correction, analyze the Flux Conversion Factors used to convert instrumental units to physical flux units as a function of date and observation time, present information on the beam profiles for each wavelength, and update secondary calibrator source fluxes. Between 07:00 and 17:00 UTC, the portion of the night that is most stable to temperature gradients that cause dish deformation, the total flux uncertainty and the peak flux uncertainty measured at 450 μm are found to be 14% and 17%, respectively. Measured at 850 μm, the total flux and peak flux uncertainties are 6% and 7%, respectively. The analysis presented in this work is applicable to all SCUBA-2 projects observed since 2011.
External Inverse-Compton Emission from Low-luminosity Gamma-Ray Bursts: Application to GRB 190829A
Authors: Zhang B. Theodore , Murase Kohta , Veres Péter , Mészáros Péter 
Published: October 2021

Abstract
The detection of TeV gamma-ray bursts (GRBs) brought new opportunities for studying the physics of particle acceleration at relativistic shocks. The High Energy Stereoscopic System (H.E.S.S.) telescopes recently observed very-high-energy (VHE) emission from a nearby low-luminosity GRB, GRB 190829A. Follow-up observations with, e.g., Swift-XRT, revealed unusual flare activities at ∼103 s, which can be caused by a long-lasting central engine. We show that the VHE emission during the H.E.S.S. observation time is naturally produced in the external inverse-Compton (EIC) scenario, where seed photons supplied by the flares or other late-time dissipations are upscattered to VHE energies by the nonthermal electrons accelerated at the external forward shock. Our calculations show that the EIC flare nearly coincides with the late-prompt flare, but extends ∼3–4 times longer than the duration of the late-prompt flare. The preferred kinetic energy and initial Lorentz factor used in our model are ∼1052 erg and ∼20, respectively. Understanding the mechanisms of the VHE emission from low-luminosity GRBs will help us constrain the properties of the outflow and the central engine activities, as well as the particle acceleration mechanism.
A Family Tree of Optical Transients from Narrow-line Seyfert 1 Galaxies
Authors: Frederick Sara , Gezari Suvi , Graham Matthew J. , Sollerman Jesper , van Velzen Sjoert , Perley Daniel A. , Stern Daniel , Ward Charlotte , Hammerstein Erica , Hung Tiara , Yan Lin , Andreoni Igor , Bellm Eric C. , Duev Dmitry A. , Kowalski Marek , Mahabal Ashish A. , Masci Frank J. , Medford Michael , Rusholme Ben , Smith Roger , Walters Richard 
Published: October 2021

Abstract
The Zwicky Transient Facility (ZTF) has discovered five events (0.01 < z < 0.4) belonging to an emerging class of active galactic nuclei (AGNs) undergoing smooth, large-amplitude, and rapidly rising flares. This sample consists of several transients initially classified as supernovae with narrow spectral lines. However, upon closer inspection, all of the host galaxies display Balmer lines with FWHM(Hβ) ∼ 900–1400 km s−1, characteristic of a narrow-line Seyfert 1 (NLSy1) galaxy. The transient events are long lived, over 400 days on average in the observed frame. We report UV and X-ray follow-up of the flares and observe persistent UV emission, with two of the five transients detected with luminous X-ray emission, ruling out a supernova interpretation. We compare the properties of this sample to previously reported flaring NLSy1 galaxies and find that they fall into three spectroscopic categories: 1) Balmer line profiles and Fe ii complexes typical of NLSy1s, 2) strong He ii profiles, and 3) He ii profiles including Bowen fluorescence features. The latter are members of the growing class of AGN flares attributed to enhanced accretion reported by Trakhtenbrot et al. We consider physical interpretations in the context of related transients from the literature. For example, two of the sources show high-amplitude rebrightening in the optical, ruling out a simple tidal disruption event scenario for those transients. We conclude that three of the sample belong to the Trakhtenbrot et al. class and two are tidal disruption events in NLSy1s. We also hypothesize as to why NLSy1s are preferentially the sites of such rapid enhanced flaring activity.
GRB 180720B: A GRB with Interesting Spectral Characteristics
Authors: Chen Jia-Ming , Peng Zhao-Yang , Du Tan-Tan , Yin Yue , Wu Hui 
Published: October 2021

Abstract
The radiation mechanism and jet composition of gamma-ray bursts (GRBs) are still two important unresolved issues, and studying its energy spectrum characteristics can provide us with evidence. In this paper, we first use the smoothly broken power-law function (Band) and the cutoff power-law function to perform Bayesian time-resolved spectrum analysis on GRB 180720B and find these spectra can be well fitted. When the thermal component is added, approximately 40% of the resolution spectrum fitting statistics are significantly improved, indicating that there is a thermal spectral component in the burst. The thermal spectra are concentrated at the beginning and peak stage of the pulses. Therefore, the burst also supports that the GRB jet component transitions from material dominance to magnetic dominance. The values of the low-energy spectrum index α of the time-resolved spectra do not exceed the so-called synchrotron line of death, regardless of whether the thermal components are added or not, which indicates that the burst can be explained by synchrotron radiation. Moreover, we find that both α and E

p
track the flux, but their tracking modes are different. We use the synchrotron model to fit these time-resolved spectra and find that these spectra can also be well fitted by the model. Furthermore, we find that both the electron spectrum index p and the magnetic field strength B track the flux and are positively correlated with the flux. Our results also show that the Band function can be explained by the synchrotron model in the Gamma-ray Burst Monitor energy range.
Search for Neutrinos from the Tidal Disruption Events AT2019dsg and AT2019fdr with the ANTARES Telescope
Authors: Albert A. , Alves S. , André M. , Anghinolfi M. , Anton G. , Ardid M. , Aubert J.-J. , Aublin J. , Baret B. , Basa S. , Belhorma B. , Bendahman M. , Benfenati F. , Bertin V. , Biagi S. , Bissinger M. , Boumaaza J. , Bouta M. , Bouwhuis M. C. , Brânzaş H. , Bruijn R. , Brunner J. , Busto J. , Caiffi B. , Capone A. , Caramete L. , Carr J. , Carretero V. , Celli S. , Chabab M. , Chau T. N. , El Moursli R. Cherkaoui , Chiarusi T. , Circella M. , Coleiro A. , Colomer-Molla M. , Coniglione R. , Coyle P. , Creusot A. , Díaz A. F. , Wasseige G. de , Deschamps A. , Distefano C. , Palma I. Di , Domi A. , Donzaud C. , Dornic D. , Drouhin D. , Eberl T. , Eeden T. van , Khayati N. El , Enzenhöfer A. , Fermani P. , Ferrara G. , Filippini F. , Fusco L. , García R. , Gatelet Y. , Gay P. , Glotin H. , Gozzini R. , Graf K. , Guidi C. , Hallmann S. , Haren H. van , Heijboer A. J. , Hello Y. , Hernández-Rey J. J. , Hößl J. , Hofestädt J. , Huang F. , Illuminati G. , James C. W. , Jisse-Jung B. , Jong M. de , Jong P. de , Jongen M. , Kadler M. , Kalekin O. , Katz U. , Khan-Chowdhury N. R. , Kouchner A. , Kreykenbohm I. , Kulikovskiy V. , Lahmann R. , Le Breton R. , Lefèvre D. , Leonora E. , Levi G. , Lincetto M. , Lopez-Coto D. , Loucatos S. , Maderer L. , Manczak J. , Marcelin M. , Margiotta A. , Marinelli A. , Martínez-Mora J. A. , Melis K. , Migliozzi P. , Moser M. , Moussa A. , Muller R. , Nauta L. , Navas S. , Nezri E. , Fearraigh B. Ó , Organokov M. , Păvălaş G. E. , Pellegrino C. , Perrin-Terrin M. , Piattelli P. , Pieterse C. , Poirè C. , Popa V. , Pradier T. , Randazzo N. , Reck S. , Riccobene G. , Romanov A. , Greus F. Salesa , Samtleben D. F. E. , Sánchez-Losa A. , Sanguineti M. , Sapienza P. , Schnabel J. , Schumann J. , Schüssler F. , Spurio M. , Stolarczyk Th. , Taiuti M. , Tayalati Y. , Tingay S. J. , Vallage B. , Van Elewyck V. , Versari F. , Viola S. , Vivolo D. , Wilms J. , Zavatarelli S. , Zegarelli A. , Zornoza J. D. , Zúñiga J. ,   (ANTARES Collaboration)
Published: October 2021

Abstract
On 2019 October 1, the IceCube Collaboration detected a muon track neutrino with a high probability of being of astrophysical origin, IC191001A. After a few hours, the tidal disruption event (TDE) AT2019dsg, observed by the Zwicky Transient Facility (ZTF), was indicated as the most likely counterpart of the IceCube track. More recently, the follow-up campaign of the IceCube alerts by ZTF suggested a second TDE, AT2019fdr, as a promising counterpart of another IceCube muon track candidate, IC200530A, detected on 2020 May 30. Here, these intriguing associations are followed-up by searching for neutrinos in the ANTARES detector from the directions of AT2019dsg and AT2019fdr using a time-integrated approach. As no significant evidence for space clustering is found in the ANTARES data, upper limits on the one-flavor neutrino flux and fluence are set.