bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lessons Learned for Identifying and Annotating Permissions in Clinical Consent Forms
Authors: Umberfield Elizabeth E. , Jiang Yun , Fenton Susan H. , Stansbury Cooper , Ford Kathleen , Crist Kaycee , Kardia Sharon L. R. , Thomer Andrea K. , Harris Marcelline R. 
Published: June 2021

AbstractBackground The lack of machine-interpretable representations of consent permissions precludes development of tools that act upon permissions across information ecosystems, at scale.Objectives To report the process, results, and lessons learned while annotating permissions in clinical consent forms.Methods We conducted a retrospective analysis of clinical consent forms. We developed an annotation scheme following the MAMA (Model-Annotate-Model-Annotate) cycle and evaluated interannotator agreement (IAA) using observed agreement (A o), weighted kappa (κw ), and Krippendorff's α.Results The final dataset included 6,399 sentences from 134 clinical consent forms. Complete agreement was achieved for 5,871 sentences, including 211 positively identified and 5,660 negatively identified as permission-sentences across all three annotators (A o = 0.944, Krippendorff's α = 0.599). These values reflect moderate to substantial IAA. Although permission-sentences contain a set of common words and structure, disagreements between annotators are largely explained by lexical variability and ambiguity in sentence meaning.Conclusion Our findings point to the complexity of identifying permission-sentences within the clinical consent forms. We present our results in light of lessons learned, which may serve as a launching point for developing tools for automated permission extraction.
Application of Risk Scores for Hepatocellular Carcinoma in Patients with Chronic Hepatitis B: Current Status and Future Perspective
Authors: Hsu Yao-Chun , Tseng Cheng-Hao , Huang Yen-Tsung , Yang Hwai-I 
Published: June 2021

AbstractAccurate risk prediction for hepatocellular carcinoma (HCC) among patients with chronic hepatitis B (CHB) may guide treatment strategies including initiation of antiviral therapy and also inform implementation of HCC surveillance. There have been 26 risk scores developed to predict HCC in CHB patients with (n = 14) or without (n = 12) receiving antiviral treatment; all of them invariably include age in the scoring formula. Virological biomarkers of replicative activities (i.e., hepatitis B virus DNA level or hepatitis B envelope antigen status) are frequently included in the scores derived from patients with untreated CHB, whereas measurements that gauge severity of liver fibrosis and/or reserve of hepatic function (i.e., cirrhosis diagnosis, liver stiffness measurement, platelet count, or albumin) are essential components in the scores developed from treated patients. External validation is a prerequisite for clinical application but not yet performed for all scores. For the future, higher predictive accuracy may be achieved with machine learning based on more comprehensive data.
The Expression of Recombinant Human Serum Albumin in the Mammary Gland of Transgenic Mice
Authors: Gong Gui-Hua , Han Shu , Huang Xiao-Ling , Xie Li-Ping , Zhang Wei , Xu Lei , Hu You-Jia 
Published: June 2021

AbstractHuman serum albumin (HSA) is widely used in the clinic for the treatment of several diseases in large amount each year. With the increasing demands of HSA in clinic and limited blood resource, recombinant HSA (rHSA) is becoming an attractive and alternative source for HSA production. In this study, we aimed to express rHSA in the mammary glands of transgenic mice by using a tissue-specific promoter and other regulatory elements. An rHSA expression vector was constructed bearing the cDNA and first intron of HSA under the control of bovine αs1-casein promoter with a 2 × chicken β-globin insulator in the front. Transgenic mice were generated and reverse transcription polymerase chain reaction showed that rHSA was expressed only in the mammary gland, indicating the tissue specificity of the bovine αs1-casein promoter in directing transgene transcription in transgenic mice. Enzyme-linked immunosorbent assay test showed that rHSA was successfully secreted into the milk of transgenic mice with the highest level at 1.98 ± 0.12 g/L. Our results indicate the ability of the bovine αs1-casein promoter to induce successful expression of rHSA in the mammary gland of transgenic mice.
Neonatal Atypical Hemolytic Uremic Syndrome in the Eculizumab Era
Authors: Gomes Sara Madureira , Teixeira Rita Pissarra , Rocha Gustavo , Soares Paulo , Guimaraes Hercilia , Santos Paulo , Jardim Joana , Barreira João Luís , Pinto Helena 
Published: June 2021

AbstractThe atypical hemolytic uremic syndrome (aHUS) in the newborn is a rare disease, with high morbidity. Eculizumab, considered a first-line drug in older children, is not approved in neonates and in children weighing less than 5 kg. We present a 5-day-old female newborn, born at 36 weeks' twin gestation, by emergency cesarean section due to cord prolapse, with birth weight of 2,035 g and Apgar score of 7/7/7, who develops microangiopathic hemolytic anemia, thrombocytopenia, and progressive acute renal failure. In day 5, after diagnosis of aHUS, a daily infusion of fresh frozen plasma begins, with improvement of thrombocytopenia and very slight improvement in renal function. The etiologic study (congenital infection, Shiga toxin, ADAMTS13 activity, directed metabolic study) was normal. C3c was slightly decreased. On day 16 for maintenance of anemia and severe renal failure, she started 300 mg/dose eculizumab. Anemia resolves in 10 weeks and creatinine has normal values after 13 weeks of treatment. The genetic study was normal. In this case, eculizumab is effective in controlling microangiopathy and in the recovery of renal function. Diagnosis of neonatal aHUS can be challenging because of phenotypic heterogeneity and potential overlap with other manifestations that may confound it, such as perinatal asphyxia or sepsis/disseminated intravascular coagulation.
Nursing Attitudes and Practices in Code Documentation Employing a New Electronic Health Record
Authors: Whalen Kimberly , Grella Pat , Snydeman Colleen , Dwyer Ann-Marie , Yager Phoebe 
Published: June 2021

Abstract
Objective Based on feedback from nurses regarding the challenges of code documentation following the implementation of a new electronic health record (EHR), we sought to better understand inpatient nurse attitudes and practices in code documentation and to identify opportunities for improvement.
Methods An anonymous electronic survey was distributed to all inpatient nurses working at a single, 999-bed, university-based, and quaternary care hospital. Participation in the study was voluntary and consent was implied by survey completion.
Results Overall, 432 (14%) of 3,121 inpatient nurses completed the survey. While nearly 80% of respondents indicated feeling very comfortable using computers for personal use, only 5% felt very comfortable navigating the EHR to document codes in real time. While 53% had documented codes in the new EHR, most admitted to documenting on paper with retroactive entry into the EHR. About 25% reported having participated in a code that was not accurately documented in the new EHR. All respondents provided specific suggestions for improving the EHR interface, and over 90% expressed interest in having opportunities to practice code documentation using simulated code events.
Conclusion Despite completion of training modules in code documentation in a new EHR, many inpatient nurses in a single institution feel uncomfortable documenting codes directly into the EHR, and some question the accuracy of this documentation. Improving EHR functionality based on specific recommendations from end-users coupled with more practice documenting simulated codes may ease EHR navigation, leading to nurses' acceptance of the EHR tool, more accurate and efficient documentation, greater nurse satisfaction and more appropriate quality improvement measures.
Price-related consumer discussions in China and the United States: a cross-cultural study investigating price perceptions and word-of-mouth transmission
Authors: Schneider Sebastian 
Published: June 2021

AbstractPrices are among the most frequently discussed topics in consumer research. Although word-of-mouth is known to be highly influential and it is considered to be of growing importance, previous research has largely neglected price-related word-of-mouth, especially in a cross-cultural context. The present study fills this research gap by analyzing the effects of price-related word-of-mouth valence, price changes communicated by word-of-mouth, market mavenism and national culture on price fairness and expensiveness perceptions, as well as on subsequent word-of-mouth intentions. Two studies employing Hofstede’s national culture dimensions reveal considerable differences between the cultures of the United States and China.
Down from the “Ivory Tower”? Not so much…Italian political scientists and the constitutional referendum campaign
Authors: Vicentini Giulia , Pritoni Andrea 
Published: June 2021

AbstractAcademics are often accused of being secluded in their “ivory towers”, focused on research and teaching but uninterested in, or unable to engage with, the public debate. If this is actually the case, under what conditions and at what particular moment is this likely to change? Following on three relevant dimensions—the visibility of political scientists, their partisanship and their impact in the public sphere—and combining press analysis with original survey data, this article has two main aims: first, to assess Italian political scientists’ (IPSs) social relevance in a period of huge political and institutional conflict such as the constitutional referendum held in December 2016; second, to explore the potential factors leading IPSs to be more or less present in the public debate. For the former, we focus on the public visibility of IPSs during the referendum campaign, as well as on the content of their public interventions, both concerning their neutral/partisan stance and their attitudes towards the constitutional reform. For the latter, we empirically test a few personal and institutional factors that are likely to influence individuals’ participation in the referendum debate.
Initial operation and data processing on a system for real-time evaluation of Thomson scattering signals on the Large Helical Device
Authors: Hammond K. C. , Laggner F. M. , Diallo A. , Doskoczynski S. , Freeman C. , Funaba H. , Gates D. A. , Rozenblat R. , Tchilinguirian G. , Xing Z. , Yamada I. , Yasuhara R. , Zimmer G. , Kolemen E. 
Published: June 2021

A scalable system for real-time analysis of electron temperature and density based on signals from the Thomson scattering diagnostic, initially developed for and installed on the NSTX-U experiment, was recently adapted for the Large Helical Device and operated for the first time during plasma discharges. During its initial operation run, it routinely recorded and processed signals for four spatial points at the laser repetition rate of 30 Hz, well within the system’s rated capability for 60 Hz. We present examples of data collected from this initial run and describe subsequent adaptations to the analysis code to improve the fidelity of the temperature calculations.
Multireference calculations on the ground and lowest excited states and dissociation energy of LuF
Authors: Almeida Nuno M. S. , Melin Timothé R. L. , Wilson Angela K. 
Published: June 2021

High level multireference calculations were performed for LuF for a total of 132 states, including four dissociation channels Lu(2D) + F(2P), Lu(2P) + F(2P), and two Lu(4F) + F(2P). The 6s, 5d, and 6p orbitals of lutetium, along with the valence 2p and 3p orbitals of fluorine, were included in the active space, allowing for the accurate description of static and dynamic correlation. The Lu(4F) + F(2P) channel has intersystem spin crossings with the Lu(2P) + F(2P) and Lu(2D) + F(2P) channels, which are discussed herein. To obtain spectroscopic constants, bond lengths, and excited states, multi-reference configuration interaction (MRCI) was used at a quadruple-ζ basis set level, correlating also the 4f electrons and corresponding orbitals. Core spin–orbit (C-MRCI) calculations were performed, revealing that 13Π0− is the first excited state closely followed by 13Π0+. In addition, the dissociation energy of LuF was determined at different levels of theory, with a range of basis sets. A balance between core correlation and a relativistic treatment of electrons is fundamental to obtain an accurate description of the dissociation energy. The best prediction was obtained with a combination of coupled-cluster single, double, and perturbative triple excitations /Douglas–Kroll–Hess third order Hamiltonian methods at a complete basis set level with a zero-point energy correction, which yields a dissociation value of 170.4 kcal mol−1. Dissociation energies using density functional theory were calculated using a range of functionals and basis sets; M06-L and B3LYP provided the closest predictions to the best ab initio calculations.
Investigation of the effect of using radiation protective glasses on the photon fluence-to-dose conversion coefficients of eye substructures
Authors: Ebrahimi-Khankook Atiyeh , Vejdani-Noghreiyan Alireza , Ziyaei-Laeen Shirin 
Published: June 2021

Abstract
The use of radiation protective glasses is common in radiation-contaminated environments. However, the effect of these glasses has not yet been investigated on the fluence-to-dose conversion coefficients (DCCs). The aim of this study is to investigate the effect of five types of gamma ray protective glasses on the photon fluence-to-DCCs of different eye substructures. For this purpose, a real eye model has been used and its conversion coefficients have been calculated in the presence of five types eye protective glasses with chemical formulae of ZnO–PbO–B2O3, Bi2O3–PbO–B2O3, PbO–B2O3, PbO–BaO–Na2O–MgO–B2O3 and BaO–Nb2O3–P2O5. Calculations were performed for monoenergetic photon sources, whose energy ranges from 0.02 to 10 MeV, with different polar and azimuthal angles. The results indicate that the use of radiation protective glasses has acceptable effects on reducing the fluence-to-DCCs only at low photon energies up to 500 keV. At medium energy levels up to about 1 MeV, the effect of the glasses is negligible. However, at high energies it increases the fluence-to-DCCs for sensitive parts of the eye.
Matching for random systems with an application to minimal weight expansions
Authors: Dajani Karma , Kalle Charlene , Maggioni Marta 
Published: June 2021

Abstract
We extend the notion of matching for one-dimensional dynamical systems to random matching for random dynamical systems on an interval. We prove that for a large family of piecewise affine random systems of the interval the property of random matching implies that any invariant density is piecewise constant. We further introduce a one-parameter family of random dynamical systems that produce signed binary expansions of numbers in the interval [−1, 1]. This family has random matching for Lebesgue almost every parameter. We use this to prove that the frequency of the digit 0 in the associated signed binary expansions never exceeds

1

2

.
Mathematical analysis of Poisson–Nernst–Planck models with permanent charges and boundary layers: studies on individual fluxes
Authors: Chen Jianing , Wang Yiwei , Zhang Lijun , Zhang Mingji 
Published: June 2021

Abstract
This work focuses on a one-dimensional Poisson–Nernst–Planck system including small permanent charges for ionic flows with one cation and one anion through a membrane channel. Our main interest is to examine the qualitative properties of the individual fluxes with boundary layers that is more realistic for ion channel problem study. Our result shows that the individual fluxes depend sensitively on multiple system parameters such as permanent charges, channel geometry, boundary conditions (concentrations and potentials) and boundary layers. For the relatively simple setting and assumptions of the model in this work, we are able to characterize the different effects of the nonlinear interaction among these system parameters in detail and gain a better understanding of the internal dynamics of ionic flows through membrane channels. Our analysis indicates that the small positive permanent charge cannot strengthen the flux of cation while reduce that of anion. Critical electric potentials which play crucial roles in studying ionic flow properties are identified. Some can be estimated experimentally. Numerical simulations are further performed and numerical results are consistent with our analytical ones.
Lorenz attractors and the modular surface
*
Authors: Bonatti Christian , Pinsky Tali 
Published: June 2021

Abstract
We define an extension of the geometric Lorenz model, defined on the three sphere. This geometric model has an invariant one dimensional trefoil knot, a union of invariant manifolds of the singularities. It is similar to the invariant trefoil knot arising in the classical Lorenz flow near the classical parameters. We prove that this geometric model is topologically equivalent to the geodesic flow on the modular surface, once compactifying the latter.
Pressure, Poincaré series and box dimension of the boundary
Authors: Iommi Godofredo , Velozo Anibal 
Published: June 2021

AbstractIn this note we prove two related results. First, we show that for certain Markov interval maps with infinitely many branches the upper box dimension of the boundary can be read from the pressure of the geometric potential. Secondly, we prove that the box dimension of the set of iterates of a point in∂Hnwith respect to a parabolic subgroup of isometries equals the critical exponent of the Poincaré series of the associated group. This establishes a relationship between the entropy at infinity and dimension theory.
A relevant document search system model using word2vec approaches
Authors: Savittri Selina A , Amalia A , Budiman M A 
Published: June 2021

Abstract
USU Repository is an institutional digital information system provided by Universitas Sumatera Utara (USU) that preserves and distributes academic papers, such as thesis and dissertation, from all departments in USU. A search box is provided to help search relevant topics from this repository. However, sometimes the search results returned were irrelevant and did not satisfy the user’s expectations. One of the causes for this situation is that the search engine could not perform optimally, particularly if the query were long and complicated. One approach that can be used to solve the problem is using semantic search. Semantic search is an information retrieval process from a sentence that involves understanding the results returned by natural language processing. In light of this approach, this paper aimed to propose a semantic search to seek the relevance between the user’s input query and academic papers returned as search results. This study implemented word2vec method in converting sentences into vectors. This study indicated average precision scores for small datasets as 46% and 73% for larger datasets.
Usability Testing for Student Academic Information System in State Polytechnic of Creative Media
Authors: Tyas S S , Khairunisa Y 
Published: June 2021

Abstract
SIAM (Student Academic Information System) is an academic services information system that has been implemented at the State Polytechnic of Creative Media (Polimedia). It’s been two months SIAM has been integrated using Single Sign On (SSO). After we implemented SIAM new version we received a lot of complaints every day. In this research, the authors conducted a usability test on the SIAM new version in order to determine the effectiveness and performance of the application. Usability test components include effectiveness, efficiency, and satisfaction. The average usability 70% indicates that the SIAM new version has a good usability performance.
Usability evaluation of a Gamification-based programming learning platform: Grasshopper
Authors: Nuravianty R , Santoso H B , Junus K 
Published: June 2021

Abstract
Online learning allows the learning process to be carried out anywhere and anytime. However, empirical studies report several obstacles that occur in the online learning process; one of which is the lack of student involvement. The learning materials of programming lessons generally have a low level of participation. Therefore, it requires a learning approach that is more attractive, easily understood by students, and promote engagement. Gamification-based programming learning platforms are widely available today. Research on determining the effectiveness of their use, investigating the system usability scale (SUS), perceived benefits, level of satisfaction, and user experience when using it is still limited. This study aims to evaluate a Grasshopper as one of the gamification-based programming learning platforms. Thirty-one respondents who had studied various programming languages at both the high school and university levels were involved in usability testingsessions. The results of the usability evaluation using SUS showed that the score was above average. The assessment of benefits and satisfaction also showed an average value of 8.6 which indicates that most respondents were satisfied with this application.
Heart Disease Simulation with Mixed Reality Technology
Authors: Syahputra M F , Zanury R , Andayani U , Hardi S M 
Published: June 2021

Abstract
Heart disease is one of the leading causes of death in the world. Various types of heart disease include Coronary Heart Disease, Arrhythmias, Heart Failure, Heart Valves and Heart Muscle. The Ministry of Health of the Republic of Indonesia calls on the public to be smarter in responding to the terror of heart disease. One of them through the introduction and early prevention of heart disease. As time has evolved, technology has become part of society. One of the things that can be done to prevent and recognize heart disease is to utilize the use of Mixed Reality technology as a medium for learning and learning. The use of Mixed Reality technology used is a device from Microsoft is namely Hololens. By using this tool, the developer can build applications to display 3D objects and their interactions. To interact, hololens use a targetting mechanism based on the view from the user’s side, a circular viewfinder as a cursor that can be directed with head movements and 2 gestures namely airtap and bloom by the user directing the hand forward until the sensor is detected from Hololens. In this case, the researchers visualize the type of heart disease in 3D and interact by applying hand gestures or voice input as interactions.
Human Detection and Identification for Home Monitoring System
Authors: Arisandi D , Elveny M , Rahayu R 
Published: June 2021

Abstract
Currently, a monitoring system is needed to improve security and productivity in various sectors, for example in public services such as education centers, offices, banking, stations, roads, and the industrial sector. With a monitoring system, public service activities can be well monitored. Apart from public services, a home surveillance system can be implemented, making it easier for household members to monitor home security. The monitoring system camera will record the object, the human object detection process is carried out with the Histogram of Oriented Gradient, after the object is detected, the facial recognition process of the object is carried out whether it is a member of the house or not by using Learning Vector Quantization. If the object is not a member of the house, the system will send a notification in the form of a photo of the object’s face to the user’s email. For object detection with the Histogram of Oriented Gradient, an average accuracy of 90% is obtained and Learning Vector Quantization for facial recognition is 85%.