bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward a Foucauldian Literary Criticism
Authors: Devitt Ryan 
Published: November 2021

AbstractThe article argues for the renewed relevance of Foucault's early essays on literature, written throughout the 1960s, given a return to anthropological reflection in so much literary theory today (especially through affect theory and “new” phenomenologies—both of which rely on older categories supplied by psychoanalysis). On one hand, Foucault reminds us of all the “warped and twisted forms of reflection” that arise from anthropological thought, with its assumptions regarding the “unthought” and the hidden structures of sense and perception. This same Foucault, on the other hand, is deeply engaged with literature; his writings on a range of authors—from Homer and Cervantes, to Friedrich Hölderlin and the Marquis de Sade, to Georges Bataille and Maurice Blanchot—constitute nothing less than an oeuvre. And yet, despite proposals to move beyond Foucauldian critique and its orthodoxy in literary studies today, hardly anything has been thought or said about this body of work in which Foucault, as David Carroll points out, “has the most to say about literature and language.” This lacuna is all the more surprising, since Foucault's early essays offer a rich and fruitful understanding of the being of literature as more than a limpid reflection of the body. In his reading of Bataille and Blanchot in particular, Foucault offers a unique vision of literature that is neither suspicious nor negative but that, in connection with his well-known critique of finitude, culminates in a hopeful call for openness.
Canon Studies in China: Traditions, Modernization, and Revisions in the Global Context
Authors: Hui Haifeng 
Published: November 2021

AbstractThough particular texts have long held culturally foundational authority, debates over the idea of a canon and the texts that are to compose it are a much more recent phenomenon, one that originated in the United States and quickly spread to other countries. The present article situates China in the international trend of canon studies by tracing how the Chinese conceptualization of the canon was modernized in the 1990s by Western ideas when canon studies were introduced to China by Dutch scholar Douwe W. Fokkema. While embracing the Western notion of the canon as always in a dynamic process of change that involves aesthetic qualities as well as a power mechanism, Chinese scholars, under the influence of culturally specific practices of literary criticism, the Confucian principle of the golden mean, and the more recent Marxist teaching of dialectical thinking, refuse to replicate Western discourses, instead adhering to a more dialectical treatment of the mutually antagonistic positions. Moreover, China's rising international status and its pursuit of wider global influence have led Chinese scholars to approach literary (re)historiography as an opportunity to showcase Chinese scholarship and to enhance China's national image.
IP6K1 upregulates the formation of processing bodies by influencing protein-protein interactions on the mRNA cap
Authors: Shah Akruti , Bhandari Rashna 
Published: November 2021

ABSTRACT
Inositol hexakisphosphate kinase 1 (IP6K1) is a small molecule kinase that catalyzes the conversion of the inositol phosphate IP6 to 5-IP7. We show that IP6K1 acts independently of its catalytic activity to upregulate the formation of processing bodies (P-bodies), which are cytoplasmic ribonucleoprotein granules that store translationally repressed mRNA. IP6K1 does not localise to P-bodies, but instead binds to ribosomes, where it interacts with the mRNA decapping complex – the scaffold protein EDC4, activator proteins DCP1A/B, decapping enzyme DCP2 and RNA helicase DDX6. Along with its partner 4E-T, DDX6 is known to nucleate protein-protein interactions on the 5′ mRNA cap to facilitate P-body formation. IP6K1 binds the translation initiation complex eIF4F on the mRNA cap, augmenting the interaction of DDX6 with 4E-T (also known as EIF4ENIF1) and the cap-binding protein eIF4E. Cells with reduced IP6K1 show downregulated microRNA-mediated translational suppression and increased stability of DCP2-regulated transcripts. Our findings unveil IP6K1 as a novel facilitator of proteome remodelling on the mRNA cap, tipping the balance in favour of translational repression over initiation, thus leading to P-body assembly.
This article has an associated First Person interview with the first author of the paper.
Melanopsin phototransduction: beyond canonical cascades
Authors: Contreras Ely , Nobleman Alexis P. , Robinson Phyllis R. , Schmidt Tiffany M. 
Published: November 2021

ABSTRACT
Melanopsin is a visual pigment that is expressed in a small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs). It is involved in regulating non-image forming visual behaviors, such as circadian photoentrainment and the pupillary light reflex, while also playing a role in many aspects of image-forming vision, such as contrast sensitivity. Melanopsin was initially discovered in the melanophores of the skin of the frog Xenopus, and subsequently found in a subset of ganglion cells in rat, mouse and primate retinas. ipRGCs were initially thought to be a single retinal ganglion cell population, and melanopsin was thought to activate a single, invertebrate-like Gq/transient receptor potential canonical (TRPC)-based phototransduction cascade within these cells. However, in the 20 years since the discovery of melanopsin, our knowledge of this visual pigment and ipRGCs has expanded dramatically. Six ipRGC subtypes have now been identified in the mouse, each with unique morphological, physiological and functional properties. Multiple subtypes have also been identified in other species, suggesting that this cell type diversity is a general feature of the ipRGC system. This diversity has led to a renewed interest in melanopsin phototransduction that may not follow the canonical Gq/TRPC cascade in the mouse or in the plethora of other organisms that express the melanopsin photopigment. In this Review, we discuss recent findings and discoveries that have challenged the prevailing view of melanopsin phototransduction as a single pathway that influences solely non-image forming functions.
Computational Studies for Crystal Structures of Helicate Lanthanide Complexes Based on X-ray Analyses
Authors: Nakayama Naofumi , Hijikata Masahiro , Ohmagari Hitomi , Tanaka Hideyuki , Inazuka Yudai , Saito Daisuke , Obata Shigeaki , Ohta Kazuo , Kato Masako , Goto Hitoshi , Hasegawa Miki 
Published: November 2021

Abstract
Computational approaches to elucidate the phase transitions in lanthanide complexes will support understanding their electronic structure changes by weak stimuli such as gas adsorptions. There are no examples as molecular models of Ln complexes for defining parameters, due to various molecular shapes with unexpected coordination numbers resulting in different packings with different Ln ions. Here, we succeeded in determining molecular force field parameters (van der Waals; vdW for Ln = Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er and Tm; and torsion parameters of the ligand) to apply the structural optimization of a series of Ln complexes taking uniform helicate for ten Ln ions with the same ligand, L, which reported previously as LnL. SmL, ErL, and TmL were newly synthesized for this calculation and the structure and luminescence properties experimentally determined. The coordination distances surrounding Ln are along the lanthanoid contraction. It is the first case to clarify the lanthanoid contraction in a 10-coordination system of a series of Ln ions. The applied optimized structures with these parameters for Eu well exhibit correspondence to observed results for four analogous of EuL. This work will strongly push development of luminescent Ln complexes with soft-crystalline behaviour.
Cash transfers for HIV prevention: A systematic review
Authors: Stoner Marie C. D. , Kilburn Kelly , Godfrey-Faussett Peter , Ghys Peter , Pettifor Audrey E. 
Published: November 2021

Background
Given the success of cash programs in improving health outcomes and addressing upstream drivers of HIV risk such as poverty and education, there has been an increasing interest in their potential to improve HIV prevention and care outcomes. Recent reviews have documented the impacts of structural interventions on HIV prevention, but evidence about the effects of cash transfer programs on HIV prevention has not been systematically reviewed for several years.

Methods and findings
We did a systematic review of published and unpublished literature to update and summarize the evidence around cash programs for HIV prevention from January 2000 to December 17, 2020. We included studies with either a cash transfer intervention, savings program, or program to reduce school costs. Included studies measured the program’s impact on HIV infection, other sexually transmitted infections (STIs), or sexual behaviors. We screened 1,565 studies and examined 78 in full-text review to identify a total of 45 peer-reviewed publications and reports from 27 different interventions or populations. We did not do a meta-analysis given the range of outcomes and types of cash transfer interventions assessed. Most studies were conducted in sub-Saharan Africa (N = 23; South Africa, Tanzania, Malawi, Lesotho, Kenya, Uganda, Zimbabwe, Zambia, and eSwatini) followed by Mexico (N = 2), the United States (N = 1), and Mongolia (N = 1)). Of the 27 studies, 20 (72%) were randomized trials, 5 (20%) were observational studies, 1 (4%) was a case–control study, and 1 (4%) was quasi-experimental. Most studies did not identify a strong association between the program and sexual behaviors, except sexual debut (10/18 finding an association; 56%). Eight of the 27 studies included HIV biomarkers, but only 3 found a large reduction in HIV incidence or prevalence, and the rest found no statistically significant association. Of the studies that identified a statistically significant association with other STIs (N = 4/8), 2 involved incentives for staying free of the STI, and the other 2 were cash transfer programs for adolescent girls that had conditionalities related to secondary schooling. Study limitations include the small number of studies in key populations and examining interventions to reduce school costs and matched saving programs.

Conclusions
The evidence base for large-scale impacts of cash transfers reducing HIV risk is limited; however, government social protection cash transfer programs and programs that incentivize school attendance among adolescent girls and young women show the greatest promise for HIV prevention.
Analysis of chemical compositions and larvicidal activity of nut extracts from Areca catechu Linn against Aedes (Diptera: Culicidae)
Authors: Bharathithasan Madhuri , Ravindran Darvin R. , Rajendran Dinesh , Chun Sim Ka , Abbas S. A. , Sugathan Sandheep , Yahaya Zary Shariman , Said Abd Rahman , Oh Wen-Da , Kotra Vijay , Mathews Allan , Mohd Amin Mohamad Faiz , Ishak Intan H. , Ravi Rajiv 
Published: November 2021

Background
There is a growing need to use green alternative larvicidal control for Aedes larvae compared to chemical insecticides. Substantial reliance on chemical insecticides caused insecticide resistance in mosquito populations. Thus, research for alternate chemical compounds from natural products is necessary to control Aedes larvae. This study explores the analysis of chemical compositions from Areca catechu nut as a potential larvicide for Aedes (Diptera: Culicidae).

Methods
The Areca catechu nut collected from Ipoh, Perak, Malaysia was grounded into powder and used for Soxhlet extraction. The chemical analysis of the extracts and their structures were identified using the GCMS-QP2010 Ultra (Shimadzu) system. National Institute of Standards and Technology (NIST) Chemistry WebBook, Standard Reference Database 69 (https://webbook.nist.gov/chemistry/) and PubChem (https://pubchem.ncbi.nlm.nih.gov/), the two databases used to retrieve the synonyms, molecular formula, molecular weight, and 2-dimensional (2D) structure of chemical compounds. Next, following WHO procedures for larval bioassays, the extracts were used to asses larvicidal activity against early 4th instar larvae of Aedes aegypti and Aedes albopictus.

Results
The larvicidal activities were observed against early 4th stage larvae with different concentrations in the range from 200 mg/L to 1600 mg/L. The LC50 and LC95 of Aedes aegypti were 621 mg/L and 2264 mg/L respectively; whereas the LC50 and LC95 of Aedes albopictus were 636 mg/L and 2268 mg/L respectively. Mortality was not observed in the non-target organism test. The analysis using gas chromatography and mass spectrometer recovered several chemical compounds such as Arecaidine, Dodecanoic acid, Methyl tetradecanoate, Tetradecanoic acid <n->, and n-Hexadecanoic acid bioactive components. These chemical constituents were used as additive formulations in pesticides, pest control, insect repellent, and insecticidal agents.

Conclusions
Our study showed significant outcomes from the extract of Areca catechu nut and it deserves further investigation in relation to chemical components and larvicidal actions between different species of Aedes mosquitoes. Even though all these findings are fundamental, it may have some interesting potentials to be developed as natural bio-larvicidal products.
The effect of spironolactone on cardiac and renal fibrosis following myocardial infarction in established hypertension in the transgenic Cyp1a1Ren2 rat
Authors: Leader C. J. , Wilkins G. T. , Walker R. J. 
Published: November 2021

Aims
The renin-angiotensin-aldosterone axis plays a key role in mediating cardiac and kidney injury. Mineralocorticoid receptor antagonism has beneficial effects on cardiac dysfunction, but effects are less well quantified in the cardiorenal syndrome. This study investigated cardiac and kidney pathophysiology following permanent surgical ligation to induce myocardial infarction (MI) in hypertensive animals with or without mineralocorticoid receptor antagonism.

Methods
Hypertension was induced in adult male Cyp1a1Ren2 rats. Hypertensive animals underwent MI surgery (n = 6), and were then treated daily with spironolactone for 28 days with serial systolic blood pressure measurements, echocardiograms and collection of urine and serum biochemical data. They were compared to hypertensive animals (n = 4), hypertensive animals treated with spironolactone (n = 4), and hypertensive plus MI without spironolactone (n = 6). Cardiac and kidney tissue was examined for histological and immunohistochemical analysis.

Results
MI superimposed on hypertension resulted in an increase in interstitial cardiac fibrosis (p<0.001), renal cortical interstitial fibrosis (p<0.01) and glomerulosclerosis (p<0.01). Increased fibrosis was accompanied by myofibroblast and macrophage infiltration in the heart and the kidney. Spironolactone post-MI, diminished the progressive fibrosis (p<0.001) and inflammation (myofibroblasts (p<0.05); macrophages (p<0.01)) in both the heart and the kidney, despite persistently elevated SBP (182±19 mmHg). Despite the reduction in inflammation and fibrosis, spironolactone did not modify ejection fraction, proteinuria, or renal function when compared to untreated animals post MI.

Conclusion
This model of progressive cardiorenal dysfunction more closely replicates the clinical setting. Mineralocorticoid receptor blockade at a clinically relevant dose, blunted progression of cardiac and kidney fibrosis with reduction in cardiac and kidney inflammatory myofibroblast and macrophage infiltration. Further studies are underway to investigate the combined actions of angiotensin blockade with mineralocorticoid receptor blockade.
Family context and individual characteristics in antenatal care utilization among adolescent childbearing mothers in urban slums in Nigeria
Authors: Akinyemi Akanni Ibukun , Erinfolami Temitope Peter , Adebayo Samuel Olinapekun , Shah Iqbal , Elewonbi Reni , Omoluabi Elizabeth 
Published: November 2021

IntroductionAdolescent pregnancy contributes significantly to the high maternal mortality in Nigeria. Research evidence from developing countries consistently underscores Antenatal Care (ANC) among childbearing adolescents as important to reducing high maternal mortality. However, more than half of pregnant adolescents in Nigeria do not attend ANC. A major gap in literature is on the influence of family context in pregnant adolescent patronage of ANC services.MethodsThe study utilized a cross-sectional survey with data collected among adolescent mothers in urban slums in three Nigerian states namely, Kaduna, Lagos, and Oyo. The survey used a multi-stage sampling design. The survey covered a sample of 1,015, 1,009 and 1,088 childbearing adolescents from each of Kaduna, Lagos, and Oyo states respectively. Data were analyzed at the three levels: univariate, bivariate and multivariate.ResultsOverall, about 70 percent of female adolescents in our sample compared with 75 percent in the Demographic and Health Survey (DHS) had any antenatal care (ANC) visit. About 62 percent in our sample compared with 70 percent in the DHS had at least 4 ANC visits, and, about 55 percent in our sample compared with 41 percent of the DHS that had 4 ANC visits in a health facility with skilled attendant (4ANC+). Those who have both parents alive and the mother with post-primary education have higher odds of attending 4ANC+ visits. The odds of attending 4ANC+ for those who have lost both parents is almost 60% less than those whose parents are alive, and, about 40% less than those whose mothers are alive. The influence of mother’s education on 4ANC+ attendance is more significant with large disparity when both parents are dead.ConclusionThe study concludes that identifying the role of parents and community in expanding access to ANC services among adolescent mothers is important in improving maternal health in developing countries.
Body image in patients with different types of cancer
Authors: Brederecke Jan , Heise Anja , Zimmermann Tanja 
Published: November 2021

BackgroundCancer can cause physical changes and affect satisfaction with a persons’ physical appearance, which in turn can affect overall quality of life. Previous studies have primarily focused on women with breast cancer and few is known about body image in patients with other cancers and especially men. The present study compares satisfaction with body image of patients with different types of cancer with the general population and across sexes and identifies risk factors for diminished body image. Additionally, patients that were diagnosed within the last year and those living with cancer for longer are compared.MethodsIn this cross-sectional study,N= 531 cancer patients answered the German Self-Image Scale to assess body image. One samplet-tests are utilized to compare the body image of cancer patients with the general population. Stepwise regression analyses were used to identify factors associated with body image and ANOVAs with posthoc tests as well ast-tests were used to examine group differences.ResultsCancer patients showed diminished body image compared to the general population. For men, higher relationship satisfaction and lower cancer-specific distress were associated with more positive body self-acceptance (SA), whereas younger age, higher relationship satisfaction, and lower cancer-specific distress resulted in better perceived partner-acceptance of one’s body (PA). In women, higher education, lower anxiety and cancer-specific distress were associated with more positive SA. Female cancer patients with breast/gynecological cancer reported better SA than those with visceral cancers. Higher relationship satisfaction and lower cancer-specific distress were found to be associated with more satisfactory PA in females. Time since diagnosis did not affect body image in this study.ConclusionsResults indicate that cancer patients regardless of sex tend to have decreased body image satisfaction. Future research directions include examination of additional entities of cancer, deeper research in men and the role of time since diagnosis.
From Galileo to Navier and Clapeyron
Authors: Pons Josep Maria 
Published: November 2021

Galileo (1564-1642), in his well-known Discorsi (Galileo, 1638), briefly turning his attention to the fracture of a beam, starts an interesting discussion on the beam’s breakage as well as its location. Could the section and breaking point of a beam have been determined beforehand? Furthermore, is it specific to the material? What Galileo did was not merely challenge a physics problem, but the prevailing knowledge of his time: namely, Aristotelianism on one hand, and Nominalism on the other. As a matter of fact, must the breakage of an element be treated as a universal or is it particular to a given material?
The present essay aims to prove how Galileo, confronting the structural problem and bringing it into the realm of science, was not just raising a problem but, using Salviati’s words, he also established what actually takes place. Many years later, with the progress of physics, strength of materials and theory of structures, figures such as Claude Navier (1785-1836) and Benoît Clapeyron (1799-1864) confirmed once again that the Pisan turned out to be right.
This article intends to combine technical fields such as strength of materials and theory of structures with others like the history of science and philosophy proper. A cooperative approach to these disciplines can be doubtlessly helpful to improve the knowledge, learning and teaching of their different curricula, giving the reader a global, holistic perspective.
Soluble vascular cell adhesion molecule-1 levels and severity of dengue hemorrhagic fever in children
Authors: Nolitriani Nolitriani , Mariko Rinang , Mayetti Mayetti 
Published: November 2021

Background The clinical manifestations of dengue infection vary widely, ranging from asymptomatic to severe forms that can cause death. In severe infections, the expression of soluble vascular cell adhesion molecule-1 (sVCAM-1) in endothelial cells is reportedly excessive, causing endothelial cell gaps through VE-cadherin and plasma leakage, which is the basic mechanism for shock in dengue hemorrhagic fever (DHF).
Objective To determine the association between sVCAM-1 levels and severity of dengue hemorrhagic fever in children.
Methods This cross-sectional study was done in children with DHF at Dr. M. Djamil Hospital, Padang, West Sumatera. Subjects were diagnosed according to the 2011 WHO criteria and selected by consecutive sampling. They were grouped as DHF with or without shock. Examination of sVCAM-1 levels was done by ELISA method. Mann-Whitney test with a significance of P<0.05 was used for statistical analysis.
Results A total of 66 patients were collected from January 2018 to December 2019, but 2 patients were excluded. The 64 subjects who met the inclusion criteria consisted of 32 (50%) DHF without shock and 32 (50%) DHF with shock. Median sVCAM-1 was significantly higher in the DHF with shock group (840 ng/mL) than in DHF without shock group (598 ng/mL) (P<0.05).
Conclusion There was a significant association between higher sVCAM-1 levels and greater severity of dengue hemorrhagic fever in children.