bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemberdayaan Kelompok Wanita Mawar Melalui Teknologi Pengolahan Produk Ayam Pedaging
Authors: Nurlaila Selvia , Purdiyanto Joko , Umar Malikah , Kurnadi Bambang 
Published: August 2021

Pelaksanaan Program pengabdian kepada masyarakat dapat memberikan informasi, teknologi dan penerapannya dengan harapan adanya program ini dapat meningkatkan pendapatan ekonomi kelompok wanita Mawar serta bisa berkompetisi dengan menghasilkan produk berdaya jual tinggi dan dapat memasarkannya. Desa Bukek merupakan salah satu Desa di Kecamatan Tlanakan Kabupaten Pamekasan. Mayoritas pekerjaan masyarakat adalah bertani dan beternak. Rata-rata pendapatannya diperoleh melalui kepala keluarga, dan kebanyakan ibu rumah tangga tidak memiliki pekerjaan. Komoditas ternak yang dipelihara antara lain sapi, kambing, domba, kelinci, ayam buras, ayam petelur, ayam pedaging dan itik. Dalam pemeliharaan tidak jarang perempuan mengambil alih pekerjaan ini. Produksi ayam pedaging menjadi salah satu produk ternak unggas di wilayah ini. Awalnya mereka kurang menyukai mengkonsumsi daging ayam ras namun seiring pengetahuan yang mereka dapatkan akan gizi ayam pedaging timbul keinginan untuk mengetahui cara pengolahan produk ayam pedaging ini sehingga semua produk dari ayam pedaging dan hasil ikutannya menjadi produk yang mempunyai nilai jual tinggi.
Discrepancies of RET gene and risk of differentiated thyroid carcinoma
Authors: Rashid Faiza A. , Khan Mosin S. , Tabassum Sobia , Aiman Aiffa , Jadoon Maharij H. 
Published: August 2021

BACKGROUND: Somatic variations in rearranged during transfection (RET) proto-oncogene acts to influence Thyroid cancer (TC) in a low penetrance manner, but their effects tend to vary between different populations. OBJECTIVE: This case-control study was aimed to evaluate effect of RET G691S, S904S and L769L single nucleotide polymorphisms (SNPs) on the risk for differentiated thyroid carcinoma (DTC). METHODS: A total of 180 patients and 220 controls were genotyped by Polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP). Di-Deoxy Sanger sequencing was performed on 100 samples with variations and 20 wild samples for each amplified exon. In addition, In Silico tools were used to evaluate structural and functional impact of individual SNPs in disease progression. RESULTS: In RET G691S/L769L/S904S SNPs, frequency of variant genotypes in DTC cases was 61.1%, 54.4% and 76.6% as compared to 45.9%, 43.6% and 89.09% in controls respectively (P⩽ 0.05). In Silico analysis revealed that different protein formed due to G691S substitution decreases the stability of 3D structure of protein. The RET G691S and L769L SNP followed “Dominant” but RET S904S SNP confirmed an “Additive” mode of inheritance. CONCLUSION: RET G691S/L769L/S904S SNPs are significantly associated with DTC with G691S SNP declining the stability of final protein product.
Measures of Risk for Sepsis and Mortality in Severe Burned Patients with Stress Induced Hyperglycemia.
Authors: Aleksi Albana , Belba Monika 
Published: August 2021

Background; Hyperglycemia as a medical condition due to diabetes or other underlying conditions like Stress-Induced Hyperglycemia and sepsis as a life-threatening medical condition are two of the challenges faced during burn treatment.
The purpose of this study was to evaluate the risk for sepsis and mortality for the patients with critical hyperglycemic values during the disease.
Material and Methods; This is an observational retrospective cohort study conducted in the Service of Burns of the University Hospital Centre “Mother Teresa” in Tirana (UHCT), Albania from 1st January 2010 to 31st December 2014. Patients were categorized as having euglycemia (mean BG values ranging from 80-120 mg/dl), moderate hyper Sepsis was defined according to the ABA Consensus Panel Publication for Infection and Sepsis glycemia (mean BG values <180 mg/dl) or critical hyperglycemia (mean BG values ≥180 mg/dl). to evaluate the impact of the presence of critical hyperglycemia during the disease in sepsis and mortality, we performed Relative risk, Odds ratio
Results; Those who had overall hyperglycemia (Moderate and Critical) had 2.6 times the risk for sepsis compared to those who were in the euglycemia group. Analyzing the risk of mortality in patients with overall hyperglycemia during the disease, we observed that the chance of a bad outcome was 2.7 times more likely to occur if the patient had hyperglycemia (RR=2.7).
Conclusions: Glucose values on admission, as one of the derangement features of burn shock, are prognostic factors in critical hyperglycemia during burn disease and have a close relationship with other outcomes (sepsis and mortality).
The Complex Femoral injuries after Hippopotamus Bite.
Authors: Kovalenko Fedor , Vassiliu Pantelis , Degiannis Konstantinos , Doll Dietrich 
Published: August 2021

Introduction. Attacks by large animals, which lead to a critical patient condition, have not been systematically and statistically analyzed in the previous literature. Some papers about animal attacks are case reports and address fatal cases. Hippopotamus bite injury is a major trauma associated with complications.
Case report. In 2018, an American woman celebrating her 37th birthday in Zimbabwe embarked on a river rafting trip. After the hippopotamus bite, the patient had extensive soft tissue injuries and a comminuted fracture of the right femur. It was undertaken extensive multiple wound debridement and the femur was nailed as the site of entrance of the nail was away from the soft tissue injuries.
Conclusion. Usually, hippopotami avoid contact with people. Similar to many wild animals, hippopotami can attack in anticipation of danger, especially when protecting their offspring. In the present case, the inflicted injury is severe and has a combined character.
Endotracheal Intubations in Emergency Department: A Clinical Audit at a Tertiary Health Centre in South India
Authors: SM Linu , Sivam Roopasree , Paul Nikhil , George Mathen P , Babu Suresh 
Published: August 2021

Background: Endotracheal intubation in the emergency department is challenging. Hence, regular audits can help us improve our critical airway management skills. Our study aimed to evaluate the practice of endotracheal intubations performed in the emergency department.
Materials and Methods: A retrospective cross-sectional study was conducted among the patients intubated in our teaching hospital's emergency department. The study period was from November 1, 2019, to August 31, 2020. We analyzed first attempt success rates, drug use, indication, and complications.
Results: We analysed 90 endotracheal intubations, out of which 70(77.8%) were performed by emergency physicians and 20(22.2%) by anaesthetists. The first attempt success rate was 81.11% (n=73) and had significant differences between the both departments. (p value= 0.003, χ2= 7.48). More patients had medical indications compared to trauma for intubation (n=88 vs n=32) among which respiratory failure (n=25, 27.78%) was the most common indication. Rapid Sequence Intubation( RSI) adherence was 82.22% (n=74). Lignocaine (n=16, 19.75%), etomidate (n=35, 43.2%) and succinylcholine (n=65, 80.25%) were the commonly used drugs for premedication, induction and as relaxants respectively. 17(18.89%) out of 90 intubation had complications. Desaturation (n=10, 11.11%), bradycardia (n=1, 1.11%), hypotension (n=4, 44%), dental trauma (n=5, 5.55%) and oesophageal intubation (n=3, 3.33%) were observed in our study.
Conclusion: Our study is the first from India which describes the characteristics of endotracheal intubations done in the Emergency Department along with data on RSI adherence. The first attempt success rate, indications, and complications were comparable with other studies in the literature. We recommend future prospective studies to analyze success rates between different specialties and resident doctors to improve the airway management skills in the Department
ANALISIS SISTEM AKUNTANSI PENERIMAAN KAS MASUK DALAM UPAYA PENINGKATAN EFEKTIVITAS PENGENDALIAN INTERNAL
Authors: Firdarini Khoirunnisa Cahya , Wijayanti Erni 
Published: August 2021

This research aims to analyze cash receipt accounting system for room selling either in cash or on credit at Grage Business Hotel Yogyakarta. Based on Mulyadi's theory, this research evaluate internal control effectivity of the hotel, especially for cash receipt system. The element have been evaluated are organizational structure, authority and administration procedure, and implementation of duties and obligation based on each person's responsibilities. The data collection method used are observation, interview, and documentation. The results shows that implementation of internal control system as mention above at Grage Business Hotel Yogyakarta has not yet qualify Mulyadi's theory criterias. The major problem there are not segregation of duties. Cash and sales function run by receptionist while accounting and administration function run by general cashier. The implication of this research is to improve internal control of cash receipt of the hotel.
SISTEM INFORMASI MONITORING PENGGUNA NARKOBA DENGAN STUDI KASUS BNN KABUPATEN MUSIRAWAS MENGGUNAKAN METODE MVC
Authors: Sunardi Lukman , Wijaya Harma Oktavia Lingga 
Published: August 2021

Penerapan teknologi komputer dalam setiap aspek dunia perkantoran Indonesia sudah dianggap sebagai suatu kebutuhan. Tanpa memiliki sistem informasi yang tangguh dalam pencarian data akan lebih sulit dilakukan. Monitoring adalah pengumpulkan secara teratur , mengkaji dan bertindak atas informasi tentang pelaksanaan suatu proyek atau kegiatan,yang pada umumnya digunakan untuk memeriksa kinerja terhadap target serta memastikan memastikan kepatuhan terhadap peraturan. Kantor BNN Musi Rawas adalah sebuah intansi pemerintahan yang berada di kabupaten Musi Rawas, yang bertugas memantau kegiatan penyalahgunaan Zat PSIKOTROPIKA atau pun NAPZA. Permasalahan yang dihadapi BNN yaitu dalam penghitungan pengguna narkoba yang ada di Kabupaten Musi Rawas yang berada pada wilayah tertentu belum maksimal dan masih mencatat menggunakan aplikasi Ms. Word, belum menggunakan sistem yang terkomputerisasi menggunakan database, sehingga dalam pencatatan dan penyajian laporan tentang data-data pengguna narkoba di Kabupaten Musi Rawas masih belum akurat dan untuk mengukur tingkat pengangguran di suatu daerah yang berada di Kabupaten Musi Rawas masih rendah tingkat ke akuratannya. Metode pengembangan sistem yang dipakai dalam penelitian ini adalah metode waterfall dan hasil penelitian adalah sistem informasi monitoring pengguna narkoba dengan studi kasus BNN Kabupaten Musirawas menggunakan Model View Controller (MVC.
A járványügyi veszélyhelyzet megélése a próbaidős tiszthelyettesek körében
Authors: Borbély Zsuzsanna 
Published: August 2021

2020-ban hódító körútra indult a világban a koronavírus-járvány. Erre tekintettel a 2019–2020-as tanévben próbaidős évüket töltő tiszthelyettesek körében egy folyamatban levő kutatás részeként felmérték a veszélyhelyzet első két hónapjának megélését, tapasztalatait, hiszen a rendőri állomány tagjaiként a mindennapi feladatellátásukban szerepet kaptak a veszélyhelyzethez kapcsolódó tevékenységek. A vizsgálatot egy általunk összeállított, 14 kérdésből álló minikérdőívként integrálták a kutatásban használt kérdőívcsomagba. A lekérdezés online formában történt, a szakmai vizsgák időszakában (2020. május vége – június eleje), s összesen 28 fő töltötte ki a koronavírus miatt kialakult járványhelyzettel kapcsolatos kérdőívet. A válaszadók körében a hatósági házi karantén ellenőrzése, a határátkelőhelyeken ellátott szolgálat és a kijárási korlátozásokkal kapcsolatos közterületi szolgálat is megjelent feladatként. A válaszadók döntő többsége (85,7%) nem érezte érzelmileg megterhelőbbnek ezen időszak feladatellátását. Fizikálisan ugyanakkor valamivel többen értékelték megterhelőbbnek a szolgálatokat (28,6%). A mintában a legintenzívebb félelemként a családtag fertőzötté válása jelentkezett, ezt követte mások megfertőzése és a kollégák megfertőződése – saját megfertőződésüktől jelentősen kevésbé féltek. Az eredmények alapján valószínűsíthető, hogy a veszélyhelyzet első két hónapjában a próbaidős állomány számára nem jelentett kiemelkedő pszichés terhelést a járványügyi veszélyhelyzethez kapcsolódó feladatok ellátása. Habár az eredmények nem reprezentatívak, de kiindulási alapot jelenthetnek a további vizsgálatok számára, mivel a téma mindenképpen érdemes további kutatásra – különösen, hogy az őszi járványügyi helyzet jelentősen megterhelőbb mindenki számára mentálisan és fizikálisan egyaránt.
Enfoque Basado en Competencias, El. Primeras aproximaciones desde Ciencias Básicas.
Authors: Juanto Susana , Cappello Viviana , Prodanoff Fabiana , Zerbino Lia 
Published: August 2021

En este trabajo se trata de relacionar los orígenes del Enfoque Basado en Competencias (EBC), la construcción del concepto de competencias, el sustento que brinda este enfoque a los cambios propiciados por el CONFEDI, y la relación entre competencias y resultados de aprendizaje. Se discuten los cambios observados en los procesos de enseñanza y de aprendizaje en experiencias realizadas en el Departamento de Ciencias Básicas de FRLP, UTN.
Mechanisms Underlying the Anti-Suicidal Treatment Potential of Buprenorphine
Authors: Cameron Courtney M. , Nieto Steven , Bosler Lucienne , Wong Megan , Bishop Isabel , Mooney Larissa , Cahill Catherine M. 
Published: August 2021

Death by suicide is a global epidemic with over 800 K suicidal deaths worlwide in 2012. Suicide is the 10th leading cause of death among Americans and more than 44 K people died by suicide in 2019 in the United States. Patients with chronic pain, including, but not limited to, those with substance use disorders, are particularly vulnerable. Chronic pain patients have twice the risk of death by suicide compared to those without pain, and 50% of chronic pain patients report that they have considered suicide at some point due to their pain. The kappa opioid system is implicated in negative mood states including dysphoria, depression, and anxiety, and recent evidence shows that chronic pain increases the function of this system in limbic brain regions important for affect and motivation. Additionally, dynorphin, the endogenous ligand that activates the kappa opioid receptor is increased in the caudate putamen of human suicide victims. A potential treatment for reducing suicidal ideation and suicidal attempts is buprenorphine. Buprenorphine, a partial mu opioid agonist with kappa opioid antagonist properties, reduced suicidal ideation in chronic pain patients with and without an opioid use disorder. This review will highlight the clinical and preclinical evidence to support the use of buprenorphine in mitigating pain-induced negative affective states and suicidal thoughts, where these effects are at least partially mediated via its kappa antagonist properties.
Two Similar Signatures for Predicting the Prognosis and Immunotherapy Efficacy of Stomach Adenocarcinoma Patients
Authors: Yue Taohua , Zuo Shuai , Zhu Jing , Guo Shihao , Huang Zhihao , Li Jichang , Wang Xin , Liu Yucun , Chen Shanwen , Wang Pengyuan 
Published: August 2021

BackgroundGlobally, stomach adenocarcinoma (STAD)’s high morbidity and mortality should arouse our urgent attention. How long can STAD patients survive after surgery and whether novel immunotherapy is effective are questions that our clinicians cannot escape.MethodsVarious R packages, GSEA software, Metascape, STRING, Cytoscape, Venn diagram, TIMER2.0 website, TCGA, and GEO databases were used in our study.ResultsIn the TCGA and GEO, macrophage abundance of STAD tissues was significantly higher than that of adjacent tissues and was an independent prognostic factor, significantly related to the overall survival (OS) of STAD patients. Between the high- and low- macrophage abundance, we conducted differential expression, univariate and multivariate Cox analysis, and obtained 12 candidate genes, and finally constructed a 3-gene signature. Both low macrophage abundance group and group D had higher TMB and PD-L1 expression. Furthermore, top 5 common gene-mutated STAD tissues had lower macrophage abundance. Macrophage abundance and 3 key genes expression were also lower in the Epstein-Barr Virus (EBV) and HM-indel STAD subtypes and significantly correlated with the tumor microenvironment score. The functional enrichment and ssGSEA revealed 2 signatures were similar and closely related to BOQUEST_STEM_CELL_UP, including genes up-regulated in proliferative stromal stem cells. Hsa-miR-335-5p simultaneously regulated 3 key genes and significantly related to the expression of PD-L1, CD8A and PDCD1.Conclusionmacrophage abundance and 3-gene signature could simultaneously predict the OS and immunotherapy efficacy, and both 2 signatures had remarkable similarities. Hsa-miR-335-5p and BOQUEST_STEM_CELL_UP might be novel immunotherapy targets.
A New Inclusive Volcanic Risk Ranking, Part 1: Methodology
Authors: Nieto-Torres Amiel , Guimarães Leticia Freitas , Bonadonna Costanza , Frischknecht Corine 
Published: August 2021

The ever-increasing population living near active volcanoes highlights the need for the implementation of effective risk reduction measures to save lives and reduce the impact of volcanic unrest and eruptions. To help identify volcanic systems associated with potential high risk and prioritize risk reduction strategies, we introduce a new Volcanic Risk Ranking (VRR) methodology that integrates hazard, exposure, and vulnerability as factors that increase risk, and resilience as a factor that reduces risk. Here we present a description of the methodology using Mexican volcanoes as a case study, while a regional application to Latin American volcanoes is presented in a companion paper (Guimarães et al., submitted). With respect to existing strategies, the proposed VRR methodology expands the parameters associated with hazard and exposure and includes the analysis of 4 dimensions of vulnerability (physical, systemic, social, economic) and of resilience. In particular, we propose 41 parameters to be analyzed, including 9 hazard parameters, 9 exposure parameters, 10 vulnerability parameters and 13 resilience parameters. Since the number of parameters evaluated for each risk factor is different, they are normalized to have the same weight based on dedicated sensitivity analyses. In order to best illustrate the methodology, the proposed VRR is here applied to 13 Mexican volcanoes and compared with other approaches. We found that the volcanoes associated with the highest combination of hazard, exposure and vulnerability (3-factor VRR) for this geographic area are Tacaná and El Chichón regardless of the analyzed time window of eruption occurrence (i.e., &lt;1 and &lt;10 ka). Nonetheless, the volcanoes with eruption &lt;1 ka that require the most urgent actions as associated with no or few resilience measures in place are Michoacán-Guanajuato Volcanic Field and San Martín Tuxtla (4-factor VRR); the top volcanoes in the 4-factor VRR with eruption &lt;10 ka are Michoacán-Guanajuato Volcanic Field and Las Cumbres.
Lockdown Learning: Changes in Online Foreign-Language Study Activity and Performance of Dutch Secondary School Students During the COVID-19 Pandemic
Authors: van der Velde Maarten , Sense Florian , Spijkers Rinske , Meeter Martijn , van Rijn Hedderik 
Published: August 2021

The COVID-19 pandemic caused lockdowns and sudden school closures around the world in spring 2020, significantly impacting the education of students. Here, we investigate how the switch to distance learning affected study activity and performance in an online retrieval practice tool used for language learning in Dutch secondary education. We report insights from a rich data set consisting of over 115 million retrieval practice trials completed by more than 133 thousand students over the course of two consecutive school years. Our findings show that usage of the tool increased substantially at the start of lockdown, with the bulk of study activity occurring on weekday mornings. In general, students’ progress through the material was largely unaffected by lockdown, although students from the highest educational track were somewhat more likely to be on or ahead of schedule than students from lower tracks, compared to the previous year. Performance on individual study trials was generally stable, but accuracy and response time on open answer questions went up, perhaps as a result of students being more focused at home. These encouraging findings contribute to a growing literature on the educational ramifications of distance learning during lockdown.
Effects of Vitamin D-Deficient Diet on Intestinal Epithelial Integrity and Zonulin Expression in a C57BL/6 Mouse Model
Authors: Yeung Chun-Yan , Chiang Chiau Jen-Shiu , Cheng Mei-Lein , Chan Wai-Tao , Jiang Chuen-Bin , Chang Szu-Wen , Liu Chia-Yuan , Chang Ching-Wei , Lee Hung-Chang 
Published: August 2021

Background and Aims: Vitamin D (VD) plays an important role not only in mineral balance and skeletal maintenance but also in immune modulation. VD status was found correlated with the pathophysiology and severity of inflammatory bowel diseases and other autoimmune disorders. Epithelial barrier function is primarily regulated by the tight-junction (TJ) proteins. In this study, we try to establish an animal model by raising mice fed VD-deficient diet and to investigate the effects of VD-deficient diet on gut integrity and zonulin expression.Methods: Male C57BL/6 mice were administered either VD-deficient [VDD group, 25(OH)2D3 0 IU/per mouse] or VD-sufficient [VDS group, 25(OH)2D3 37.8 IU/per mouse] special diets for 7 weeks. Body weight and diet intake were recorded weekly. Serum VD levels were detected. After sacrifice, jejunum and colon specimens were collected. The villus length and crypt depth of the jejunum as well as mucosa thickness of the colon were measured. Various serum pro-inflammatory cytokines and intestinal TJ proteins were assessed. The serum level of zonulin and the mRNA expression of jejunum zonulin were also investigated.Results: We found that mice fed a VDD diet had a lower serum level of VD after 7 weeks (p &lt; 0.001). VDD mice gained significant less weight (p = 0.022) and took a similar amount of diet (p = 0.398) when compared to mice raised on a VDS diet. Significantly decreased colon mucosa thickness was found in VDD mice compared with the VDS group (p = 0.022). A marked increase in serum pro-inflammatory cytokine levels was demonstrated in VDD mice. All relative levels of claudin (CLD)-1 (p = 0.007), CLD-3 (p &lt; 0.001), CLD-7 (p &lt; 0.001), and zonulin-1 (ZO-1, p = 0.038) protein expressions were significantly decreased in the VDD group when compared to the VDS group. A significant upregulation of mRNA expression of jejunum zonulin (p = 0.043) and elevated serum zonulin (p = 0.001) were found in the VDD group.Conclusions: We successfully demonstrated that VDD could lead to impaired barrier properties. We assume that sufficient VD could maintain intestinal epithelial integrity and prevent mucosal barrier dysfunction. VD supplementation may serve as part of a therapeutic strategy for human autoimmune and infectious diseases with intestinal barrier dysfunction (leaky gut) in the future. To our knowledge, this is the first study to demonstrate that VDD could lead to a significant upregulation in mRNA expression of the jejunum zonulin level and also a marked elevation of serum zonulin in a mouse model.