bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful treatment of locally advanced lung cancer using late concurrent chemoradiation therapy administered after immune checkpoint inhibitor plus platinum chemotherapy
Authors: Matsubara Taichi , Takamori Shinkichi , Fujishita Takatoshi , Toyozawa Ryo , Ito Kensaku , Yamaguchi Masafumi , Seto Takashi , Okamoto Tatsuro 
Published: October 2021

AbstractConcurrent chemoradiation therapy (CRT) is the standard of care for patients with unresectable stage II/III lung cancer. However, systemic chemotherapy is required for patients who are ineligible for radical radiation therapy. There is little evidence to date for the safety and efficacy of CRT administered after treatment with immune checkpoint inhibitors (ICIs). The cases reported here had inoperable stage III lung cancer (non‐small cell lung cancer and small cell lung cancer) and were ineligible for radical radiation therapy. They were administered ICIs plus chemotherapy and subsequently underwent late concurrent CRT. Because of the remarkable tumor shrinkage achieved by the ICIs plus chemotherapy, adverse events of CRT were tolerable. They were alive without tumor progression as of this report, over 1 year after CRT was terminated. CRT is administered with curative intent, while the intent of immunochemotherapy is palliative. Late concurrent CRT after immunochemotherapy is probably effective and tolerable. After treatment with systemic chemotherapy in patients judged ineligible for radical radiation therapy, radiation therapy should be reconsidered because of its importance once tumor shrinkage has been achieved.
Salary disparities based on gender in academic emergency medicine leadership
Authors: Wiler Jennifer L. , Wendel Sarah K. , Rounds Kirsten , McGowan Becky , Baird Janette 
Published: October 2021

AbstractObjectiveThere are significantly fewer women than men in leadership roles in health care. Previous studies have shown that, overall, male physicians earn nearly $20,000 more annually than their female physician colleagues after adjusting for confounding factors. However, there has not been a description of physician leadership compensation in relation to gender.MethodsThis was a successive cross‐sectional observation study design of 154 emergency departments in the United States from 5 years (2013, 2015–2018) using Association of Academic Chairs in Emergency Medicine and Academy of Administrators in Academic EM survey data. The primary variable of interest, leadership role, was attained by recoding the survey responses to assign primary job duty into four main categories: no leadership role, operations leadership, education leadership, and executive leadership.ResultsOverall, 8820 responses were included. Across all survey years, the mean (±SD) percentage of women in any leadership role was significantly less than men (44.5% [95% CI: 42.8, 46.2%] vs. 55.3% [95% CI: 54.1, 56.5%]). Women in leadership roles worked more clinical hours than men in the same position (female median = 1008, male median = 960). Women also had significantly lower salaries than men at each of the 5‐year time points that data are reported, with unadjusted mean salary differences of –$54,409 per year for executives, –$27,803 for operational leaders, and –$17,803 for education leaders.ConclusionsFemale physicians hold fewer leadership roles in academic emergency medicine (EM), and when they do, they work more clinical hours and are paid less than male physicians. As a specialty, EM should continue to investigate and report on gender achievement disparities as work is done to rectify the system inequalities.
Can CEO equity‐based compensation limit investment‐related agency problems?
Authors: Qu Xin , Percy Majella , Hu Fang , Stewart Jenny 
Published: October 2021

AbstractPrevious research suggests that investment‐cash flow sensitivity (ICS) has arisen from agency costs. This study investigates whether equity‐based compensation (EBC) reduces these costs. We find that ICS is lower when companies grant EBC to chief executive officers (CEOs). EBC with long‐term vesting periods, and especially with graded vesting conditions, is associated with a lower ICS. EBC with performance hurdles is associated with higher sensitivity. However, when the performance hurdles are set as a relative market index rather than an absolute target, the sensitivity becomes lower. Our results suggest that appropriately designed EBC plays an important role in mitigating investment‐related agency problems.
Climate and behaviour influence thermal suitability of artificial hollows for a critically endangered mammal
Authors: McComb L. B. , Lentini P. E. , Harley D. K. P. , Lumsden L. F. , Eyre A. C. , Briscoe N. J. 
Published: October 2021

AbstractArtificial hollows are commonly used to mitigate the scarcity of den and nest sites that threatens fauna species globally, but there is a risk that these do not provide suitable microclimates for the populations they are intended to support. We monitored temperature, humidity and occupancy in artificial dens (nest boxes and chainsaw‐carved cavities) provided for the critically endangered Leadbeater’s possum (Gymnobelideus leadbeateri) in south‐eastern Australian forests. Monitoring occurred over both winter and summer in five habitat types spanning a broad elevational gradient (110–1580 m asl). We then used a biophysical model to explore the physiological consequences of the den temperatures recorded, and the potential effectiveness of behavioural strategies in reducing thermoregulatory costs. Monitoring revealed that nest box temperatures tracked ambient over both seasons, ranging from −5.5°C to 48.5°C, while chainsaw hollows provided more stable internal conditions. However, we found that inferences regarding the thermal suitability of artificial dens were site‐specific, and dependent upon habitat type, season and assumptions around behavioural strategies. During winter, behaviours such as the construction of large, insulative nests and huddling are likely critical in overcoming high energy costs associated with poorly insulated artificial dens. In contrast, during summer high thermoregulatory costs were predicted for the warmest (lowland) site and coincided with low nest box occupancy. Our study reinforces the importance of factoring in local climates, and behavioural and physiological strategies employed by target taxa, when implementing artificial den programs to support fauna populations.
Validity of near‐infrared light transillumination for the assessment of proximal caries in permanent teeth
Authors: Wang F , Su C , Yang C , von den Hoff JW , Bian Z , Meng L 
Published: October 2021

AbstractPurposeThe aim of this study was to evaluate the performance of DIAGNOcam (DC) in diagnosing proximal caries and to compare its effectiveness with the International Caries Detection and Assessment System (ICDAS) and bitewing radiography (BWR).Methods118 premolars extracted for orthodontic reasons were included and examined using three detection methods and validated by histological sections as the gold standard. The sensitivity, specificity and areas under the ROC curve (Az value) at the outer half enamel (D1), inner half enamel (D2) and dentine (D3) thresholds were compared between different methods.ResultsAt all categories, the specificity of DC was almost as high as ICDAS and BWR. DC showed a significantly higher sensitivity (0.68) than both visual (0.33) and radiographic examination (0.47) at the D1 threshold. DC presented the highest Az value (area under the ROC curve) at the D1 and D2 threshold (0.81, 0.86), while BWR showed the greatest Az values at D3 (0.94). Furthermore, DC had the highest association strength with the gold standard (Spearman’s ρ = 0.80).ConclusionsIt can be concluded that DC could detect proximal caries effectively and showed comparable or even better performance than ICDAS and BWR.
New observations of four waterbird species in Algerian Sahara
Authors: Chedad Abdelwahab , Bouzid Abdelhakim , Bendjoudi Djamel , Guezoul Omar 
Published: October 2021

AbstractThe range mapping and phenological status of four waterbird species was studied in Ghardaïa and El‐Ménéa regions between 2017 and 2021. Seasonal waterbird censuses were conducted throughout Ghardaïa and El‐Ménéa by individual counts or visual estimation. During these counts, four species were reported for the first time in this region, three passage visitors, European golden plover Pluvialis apricaria, black stork Ciconia nigra and Western Reef Heron Egretta gularis, and one winter stopover, common crane Grus grus. Observations on the species in Ghardaïa and El‐Ménéa regions are new for southern Algeria.
Transcriptome‐based identification of novel endotypes in adult atopic dermatitis
Authors: Lefèvre‐Utile Alain , Saichi Melissa , Oláh Péter , Delord Marc , Homey Bernhard , Soumelis Vassili ,   MAARS consortium
Published: October 2021

AbstractBackgroundAtopic dermatitis (AD) is a frequent and heterogeneous inflammatory skin disease, for which personalized medicine remains a challenge. High‐throughput approaches have improved understanding of the complex pathophysiology of AD. However, a purely data‐driven AD classification is still lacking.MethodsTo address this question, we applied an original unsupervised approach on the largest available transcriptome dataset of AD lesional (n = 82) and healthy (n = 213) skin biopsies.ResultsTaking into account pathological and physiological state, a variance‐based filtering revealed 222 AD‐specific hyper‐variable genes that efficiently classified the AD samples into 4 clusters that turned out to be clinically and biologically distinct. Comparison of gene expressions between clusters identified 3 sets of upregulated genes used to derive metagenes (MGs): MG‐I (19 genes) was associated with IL‐1 family signaling (including IL‐36A and 36G) and skin remodeling, MG‐II (23 genes) with negative immune regulation (including IL‐34 and 37) and skin architecture, and MG‐III (17 genes) with B lymphocyte immunity. Sample clusters differed in terms of disease severity (p = .02) and S. aureus (SA) colonization (p = .02). Cluster 1 contained the most severe AD, highest SA colonization, and overexpressed MG‐I. Cluster 2 was characterized by less severe AD, low SA colonization, and high MG‐II expression. Cluster 3 included mild AD, mild SA colonization, and mild expression of all MGs. Cluster 4 had the same clinical features as cluster 3 but had hyper‐expression of MG‐III. Last, we successfully validated our method and results in an independent cohort.ConclusionOur study revealed unrecognized AD endotypes with specific underlying biological pathways, highlighting novel pathophysiological mechanisms. These data could provide new insights into personalized treatment strategies.
QTc interval on 24‐hour holter monitor: To trust or not to trust?
Authors: Tamr Agha Mhd Khalil , Fakhri Ghina , Ahmed Mohamed , El Sedawy Omar , Abi Saleh Bernard , Bitar Fadi , Arabi Mariam 
Published: October 2021

AbstractIntroductionQT interval represents the ventricular depolarization and repolarization. Its accurate measurement is critical since prolonged QT can lead to sudden cardiac death. QT is affected by heart rate and is corrected to QTc via several formulae. QTc is commonly calculated on the ECG and not the 24‐h Holter.Methods100 patients presenting to our institution were evaluated by an ECG followed by a 24‐h Holter. QTc measurement on both platforms using Bazett and Fridericia formulae was recorded and compared.ResultsMean age was 14.09 years, with the majority being males. Mean heart rate was 125.87. In the ECG, the mean QTc interval via the Bazett formula was 0.40 s compared with 0.38 s using the Fridericia formula. The mean corrected QT via the Bazett formula was 0.45, 0.39, and 0.42 s for the shortest RR, the longest RR, and the average RR, respectively. In contrast to the Fridericia formula, the corrected QT interval was 0.40, 0.39, and 0.40 s for the shortest RR, the longest RR, and the average RR, respectively. Using the Bazett formula, the highest specificity was reached during the longest RR interval (92.2%), while the highest sensitivity was recorded during the shortest RR interval (40%). As for the Fridericiaformula, sensitivity always reached 0%, while the highest specificity was reached during the average RR interval.ConclusionQTc measured during Holter ECG reached a high specificity regardless of RR interval using the Fridericia and during the longest and the average RR interval for the Bazett formula. The consistently low sensitivity reveals that Holter ECG should not be used to rule out prolonged QT.
Decreased frequency of transplantation and lower post‐transplant survival free of re‐transplantation in LVAD patients with the new heart transplant allocation system
Authors: Jani Milena , Lee Sangjin , Acharya Deepak , Hoeksema Sarah , Boeve Theodore , Leacche Marzia , Manandhar‐Shrestha Nabin K. , Jovinge Stefan V. , Loyaga‐Rendon Renzo Y. 
Published: October 2021

AbstractPurposeTo evaluate the effect of the new heart transplant (HT) allocation system in left ventricular assist device (LVAD) supported patients listed as bridge to transplantation (BTT).MethodsAdult patients who were listed for HT between October 18, 2016 and October 17, 2019, and were supported with an LVAD, enrolled in the UNOS database were included in this study. Patients were classified in the old or new system if they were listed or transplanted before or after October 18, 2018, respectively.ResultsA total of 3261 LVAD patients were listed for transplant. Of these, 2257 were classified in the old and 1004 in the new system. The cumulative incidence of death or removal from the transplant list due to worsening clinical status at 360‐days after listing was lower in the new system (4% vs. 7%, P = .011). LVAD Patients listed in the new system had a lower frequency of transplantation within 360‐days of listing (52% vs. 61%, P < .001). A total of 1843 LVAD patients were transplanted, 1004 patients in the old system and 839 patients in the new system. The post‐transplant survival at 360 days was similar between old and new systems (92.3% vs. 90%, P = .08). However, LVAD patients transplanted in the new system had lower frequency of the combined endpoint, freedom of death or re‐transplantation at 360 days (92.2% vs. 89.6%, P = .046).ConclusionThe new HT allocation system has affected the LVAD‐BTT population significantly. On the waitlist, LVAD patients have a decreased cumulative frequency of transplantation and a concomitant decrease in death or delisting due to worsening status. In the new system, LVAD patients have a decreased survival free of re‐transplantation at 360 days post‐transplant.
Genetic basis of growth, spring phenology, and susceptibility to biotic stressors in maritime pine
Authors: Hurel Agathe , de Miguel Marina , Dutech Cyril , Desprez‐Loustau Marie‐Laure , Plomion Christophe , Rodríguez‐Quilón Isabel , Cyrille Agathe , Guzman Thomas , Alía Ricardo , González‐Martínez Santiago C. , Budde Katharina B. 
Published: October 2021

AbstractForest ecosystems are increasingly challenged by extreme events, for example, drought, storms, pest attacks, and fungal pathogen outbreaks, causing severe ecological and economic losses. Understanding the genetic basis of adaptive traits in tree species is of key importance to preserve forest ecosystems, as genetic variation in a trait (i.e., heritability) determines its potential for human‐mediated or evolutionary change. Maritime pine (Pinus pinaster Aiton), a conifer widely distributed in southwestern Europe and northwestern Africa, grows under contrasted environmental conditions promoting local adaptation. Genetic variation at adaptive phenotypes, including height, spring phenology, and susceptibility to two fungal pathogens (Diplodia sapinea and Armillaria ostoyae) and an insect pest (Thaumetopoea pityocampa), was assessed in a range‐wide clonal common garden of maritime pine. Broad‐sense heritability was significant for height (0.219), spring phenology (0.165–0.310), and pathogen susceptibility (necrosis length caused by D. sapinea, 0.152; and by A. ostoyae, 0.021, measured on inoculated, excised branches under controlled conditions), but not for pine processionary moth incidence in the common garden. The correlations of trait variation among populations revealed contrasting trends for pathogen susceptibility to D. sapinea and A. ostoyae with respect to height. Taller trees showed longer necrosis length caused by D. sapinea while shorter trees were more affected by A. ostoyae. Moreover, maritime pine populations from areas with high summer temperatures and frequent droughts were less susceptible to D. sapinea but more susceptible to A. ostoyae. Finally, an association study using 4227 genome‐wide SNPs revealed several loci significantly associated with each trait (range of 3–26), including a possibly disease‐induced translation initiation factor, eIF‐5, associated with needle discoloration caused by D. sapinea. This study provides important insights to develop genetic conservation and breeding strategies integrating species responses to biotic stressors.
Genetic and morphological data demonstrate hybridization and backcrossing in a pair of salamanders at the far end of the speciation continuum
Authors: Arntzen Jan W. , Jehle Robert , Wielstra Ben 
Published: October 2021

AbstractDeeply diverged yet hybridizing species provide a system to investigate the final stages of the speciation process. We study a hybridizing pair of salamander species—the morphologically and genetically drastically different newts Triturus cristatus and T. marmoratus—with a panel of 32 nuclear and mitochondrial genetic markers. Morphologically identified hybrids are mostly of the F1 generation and mothered by T. cristatus. The sex ratio of the F1 hybrid class is reciprocally skewed, with a preponderance of females in T. cristatus‐mothered hybrids and males in T. marmoratus‐mothered hybrids. This amounts to the Haldane effect operating in one direction of the cross. Deeper generation hybrids are occasionally produced, possibly including F1 hybrid × backcross hybrid offspring. Interspecific gene flow is low, yet skewed toward T. cristatus. This asymmetry may be caused by hybrid zone movement, with the superseding species being predisposed to introgression. The persisting gene flow between deeply differentiated species supports the notion that full genetic isolation may be selected against. Conversely, published morphological data suggest that introgressive hybridization is detrimental, with digital malformations occurring more frequently in the area of sympatry. Finally, to assist field identification, both within the area of natural range overlap and concerning anthropogenic introductions elsewhere, we document the phenotypical variation of two generations of hybrids compared with both parental species. We suggest that fluctuating range boundaries, ecological segregation, cytonuclear incompatibilities and hybrid breakdown through Bateson–Dobzhansky–Muller incompatibilities all contribute to species integrity, despite incomplete isolation during secondary contact.
Deep learning‐influenced joint vehicle‐to‐infrastructure and vehicle‐to‐vehicle communication approach for internet of vehicles
Authors: Mekala M. S. , Dhiman Gaurav , Patan Rizwan , Kallam Suresh , Ramana Kadiyala , Yadav Kusum , Alharbi Ali O. 
Published: October 2021

AbstractThe internet of vehicle (IoV) orchestration is an emerging technology in heterogeneous vehicles to contrivance diverse intelligent transportation applications. The roadside unit (RSU) plays a vital role during service provisioning. Vehicle‐to‐vehicle and vehicle‐to‐infrastructure communications have consistently accomplished the services in a vehicular network. However, persisting the increased vehicles' quality of experience and network vendors' utilities and which RSUs have to select for effective, reliable service are critical open research challenges to consolidate RSU services to enhance network service utility rate. In this article, we design a deep learning‐inspired RSU Service Consolidation Approach based on two‐models to enhance the service reliability by formulating the RSU coverage issue with the RSU Migration model and content delivery issue with Linear Programming‐based Multicast model. Adaptive Packet‐Error measurement system to optimize service reliability rate at the edge of cooperative vehicular network based on content correlation. The performance and efficiency are examined based on MATLAB. The simulation outcome shows RSC approach has low execution cost by 39%, service reliability rate by 71% than the state‐of‐art approaches.
A formal method for privacy‐preservation in cognitive smart cities
Authors: Khan Mohammad Ayoub 
Published: October 2021

AbstractThe Internet of things (IoT) and communication technologies are enabling the consumer to use the smart devices. The explosion of smart devices is shifting the IoT into a framework, which we call the cognitive IoT. The cognitive IoT can enhance many sectors such as smart cities, healthcare, industry 4.0, transportation, just to name a few. Most of the data produced in smart cities are wasted because the important information is not extracted due to lack of standard mechanism for knowledge extraction and archiving methods. This has attracted the attention of researcher to design new approaches of machine and cognitive learning that can handle vast amount of dynamic data. The cognitive smart city is the integration of IoT, smart city technology, real‐time big data analytics and artificial intelligence (AI) strategies for proactive actions. The services in smart cities relies on the collection and analysis of the data which are provided by the use themselves or accessed by the services providers. The citizen engagement is the key for success of smart city; however, the engagement may get reduced due to privacy concerns arising from data collection. Therefore, privacy‐preservation shall be achieved in a manner where valuable data is exchanged with service provider, and other third party while protecting the citizens' privacy, upholding data laws and enforcement. Therefore, there is a need to control the anonymization and mix some more techniques to preserve the quality of the data. The proposed formal method for privacy‐preservation in smart cities is based on pseudonymization, clustering, anonymization and differential privacy methods. The modified clustering algorithm selects the initial cluster based on the concept of dissimilarity between the data sequences. We have assessed the functional correctness and preformation of the proposed model for privacy‐preservation in smart cities. The proposed method has lower discriminating rate as compared to other existing methods.