bluuebunny/crossref_metadata_2025_split huggingface dataset:
Práticas pedagógicas: experiências inovadoras na Educação Profissional e Tecnológica
Authors: Castaman Ana Sara , Rodrigues Ricardo Antonio 
Published: February 2021

As mudanças a nível tecnológico, econômico e político no mundo da vida influenciam inegavelmente no âmbito educacional, refletindo assim, nos processos e nos modos de ensinar e de aprender. Ainda, ressalta-se que, em se tratando de práticas pedagógicas, almeja-se que em cada nível e modalidade de ensino estas devam ser planejadas e executadas a partir de sua natureza, suas particularidades e sua complexidade. Neste escopo, o presente estudo tem como objetivo conhecer os conceitos e as concepções sobre prática pedagógica, à luz das bases legais e conceituais do Currículo Integrado, de modo a apresentar práticas pedagógicas inovadoras aplicadas na educação profissional e tecnológica (EPT). Pauta-se metodologicamente em uma revisão bibliográfica de objetivos exploratórios e está dividido em duas partes: a) aborda os conceitos de prática pedagógica associando à inovação; b) discute as práticas pedagógicas inovadoras na EPT, a partir de um relato de experiência. Ressaltou-se que as práticas pedagógicas na EPT constituem-se como condição de melhor atender as demandas humanas da criatividade e da autodeterminação docente, levando em conta as exigências culturais do nosso tempo; que inovação não implica pirotecnia, mas escolha cotidiana para conduzir práticas vivas. Os educadores devem adotar estratégias de ensinagem que além de inovadoras corroborem para novos olhares à realidade social dos educandos. A realidade problematizada sobre as práticas pedagógicas inovadoras na EPT favorece e dissemina novos rumos para uma educação emancipatória.
Aspectos do estágio docente de Letras em Sala de Apoio à Aprendizagem em Língua Portuguesa
Authors: Malinoski Pianaro Angelo Cristiane , Menegassi Renilson José 
Published: February 2021

Com fundamentação nos pressupostos da perspectiva histórico-cultural advindos de Vygotsky e nas pesquisas sobre leitura e escrita desenvolvidas pela Linguística Aplicada no Brasil, este artigo descreve, discute e reflete sobre a abordagem de trabalho com as habilidades de leitura e de escrita, por uma professora em formação docente inicial, junto a alunos com dificuldades de aprendizagem. Também objetiva refletir sobre a mediação do professor formador nessa situação específica. O corpus constitutivo das análises são os relatórios de estágio de uma aluna de licenciatura em Letras-Português, de uma universidade pública do estado do Paraná, produzidos nas práticas de ensino em uma Sala de Apoio à Aprendizagem de Língua Portuguesa (SAALP), contexto em que realizou o trabalho de observação e atuação. As análises demonstram que, por meio das experiências docentes em SAALP, mediadas pelo professor supervisor, a estagiária apreende as principais dificuldades de leitura e de escrita dos alunos, assim como as estratégias e abordagens para trabalhá-las, como a contação de histórias, a leitura compartilhada, a ordenação e sequenciação de perguntas de leitura, para impulsionar processos de desenvolvimento das habilidades nesses alunos e em si própria, enquanto docente.
Indoor Air Quality in Benghazi’s Hospitals and Its Impact among Patients
Authors: Gawili Hadir , Bodabos Hawa A. , Al-Awami Wafa A. , Al-Gargouri Ahmed O. , Alhegazi Yahia F. 
Published: February 2021

Background: Indoor air quality (IAQ) is a very important topic; it contains a variety of factors: temperature, humidity, the presence of chemicals and the quality of outdoor air brought inside are typical metrics used to define IAQ. However, with poor quality usually lead to Sick Building Syndrome (SBS) and other serious symptoms.
Aims: This study aimed to investigate Indoor air diseases and their symptoms of SBS among patients in ten hospitals in Benghazi, Libya and focusing on awareness/knowledge of patients and their education level regarding some pollutants and noise pollution.
Study Design: This paper is a cross sectional descriptive study.
Place and Duration of the Study: The study was conducted in December 2019 to September 2020 in Benghazi, Libya.
Methodology: Performed sub analysis statistics have chosen 150 patients randomly in 10 hospitals (polyclinics/health centers) to fill out questionnaire about the most common symptoms are related to indoor air value in hospitals by also using the observational checklist.
Results: Mostly females 54% were of age above 46 years, 31.3% of the participants were university education level, 69.3% have suffered from different type of diseases, which are hypertension, diabetes, and asthma, and most pollutants were inducted from vehicle traffic 63.3%.
Conclusion: the study indicated the highest contaminates impact and the health criteria in all ten hospitals were under the study, which are; temperature and humidity, PM, other chemical pollutants and noise effect.
The Study of the Ground State Properties of Heavy Famion System Using an Extended Kondo-Anderson Model in One Dimension
Authors: Samuel Okunzuwa I. , Augustine C. Okaro 
Published: February 2021

The Kondo interaction coupling, Heisenberg exchange coupling, and Coulomb interactions within d-sites, were introduced in a one dimensional Periodic Anderson Model Hamiltonian (PAMH) to further investigate the effects of interaction parameters on the ground state energy of systems with heavy fermions (HF) behavior. Periodic Anderson model PAM being one of the most successful model for studying the heavy fermions System (HFS) was used in an extended version (mixed Kondo-Anderson representation) on a system of three-electrons interacting on three-sites cluster. Exact Diagonalization technique (EDT) normally used to solve conventional PAM calculation was considered in this work for a very small cluster. Hamiltonian used to describe this model contains the usual term describing the kinetic energy of the system, on-site coulomb repulsion and a hopping integral. The Hamiltonian is acted on the different Hilbert states of the lattice system and results of the interactions were obtained in terms of hopping integral, coulomb repulsions, exchange couplings and the hybridization term. Graphs of ground state energy Eo plotted agains tthese interaction parameters were presented in a clear format. As these parameters were varied numerically through a finite range of values, the individual effects of these parameters on the system’s ground state energy were observed and discussed. Hence, the results obtained from this work shows theoretically how the tuning of the Columbic interaction within the conduction band provides information that sheds light on the underlying physics of the heavy fermions systems models. Results obtained from this work further demonstrate the reliability of the model Hamiltonians that we have harnessed and the importance of considering electron-lattice interactions as well as interactions that account for magnetic impurities for the proper description of heavy fermions material.
Reverse diel vertical movements of oceanic manta rays off the northern coast of Peru and implications for conservation
Authors: Andrzejaczek Samantha , Schallert Robert J. , Forsberg Kerstin , Arnoldi Natalie S. , Cabanillas‐Torpoco Mariano , Purizaca Wilmer , Block Barbara A. 
Published: February 2021

Abstract1. An understanding of the vertical movements of elasmobranchs across their range is crucial to defining critical habitat use, its overlap with anthropogenic activities and subsequently managing such interactions.2. In this study, satellite telemetry was used to investigate the vertical habitat use of three oceanic manta rays (Mobula birostris) tagged on the northern coast of Peru.3. All three oceanic mantas exhibited patterns of reverse diel vertical migration, where vertical movements were significantly deeper at night than the day, as well as an overall preference for surface habitats (< 2 m). High‐resolution archival data (3–5 s) from two recovered tags revealed fine‐scale behaviours, where individuals predominately remained in coastal surface waters throughout the day, and oscillated up and down through a highly stratified water column at night.4. Our results suggest that coastal vertical movements were motivated by a combined foraging and thermal recovery strategy, whereby oceanic mantas dived to forage on vertically migrating zooplankton at night and returned to surface waters to rewarm between dives, indicating that the coast of northern Peru may be a foraging habitat for these animals.5. High use of surface waters here, however, may put oceanic mantas at high risk from several anthropogenic impacts such as entanglement with fishing gear and vessel strikes.6. Increased sample size and the use of other techniques, such as animal‐borne cameras and tri‐axial sensors, are required to validate our foraging and thermal recovery hypothesis and confirm this region as a foraging habitat for oceanic mantas.
Radiation treatment planning study to investigate feasibility of delivering Immunotherapy in Combination with Ablative Radiosurgery to Ultra‐High DoSes (ICARUS)
Authors: Rokni Michelle B. , Pointer Kelli B. , George Jonathan , Luke Jason J. , Chmura Steven J. , Redler Gage 
Published: February 2021

AbstractPurposeImmune checkpoint inhibitors improve survival in metastatic diseases for some cancers. Multisite SBRT with pembrolizumab (SBRT + Pembro) was shown to be safe with promising local control using biologically effective doses (BEDs) = 95–120 Gy. Increased BED may improve response rate; however, SBRT doses are limited by surrounding organs at risk (OARs). The purpose of this work was to develop and validate methods for safe delivery of ultra‐high doses of radiation (BED10 > 300) to be used in future clinical trials.Methods and MaterialsThe radiation plans from 15 patients enrolled on a phase I trial of SBRT + pembro were reanalyzed. Metastatic disease sites included liver (8/15), inguinal region (1/15), pelvis (2/15), lung (1/15), abdomen (1/15), spleen (1/15), and groin (1/15). Gross tumor volumes (GTVs) ranged from 80 to 708 cc. Following the same methodology used in the Phase I trial on which these patients were treated, GTVs > 65 cc were contracted to a 65 cc subvolume (SubGTV) resulting in only a portion of the GTV receiving prescription dose. Volumetric modulated arc therapy (VMAT) was used to plan treatments BED10 = 360 Gy. Plans utilizing both 6FFF and 10FFF beams were compared to clinical plans delivering BED10 = 112.50 Gy. The target primary goal was V100% > 95% with a secondary goal of V70% > 99% and OAR objectives per the trial. To demonstrate feasibility, plans were delivered to a diode array phantom and evaluated for fidelity using gamma analysis.ResultsAll 30 plans met the secondary coverage goal and satisfied all OAR constraints. The primary goal was achieved in 12/15 of the 6FFF plans and 13/15 of the 10FFF plans. Average gamma analysis passing rate using criteria of 3% dose difference and 3, 2, and 1 mm were 99.1 1.0%, 98.5 1.6%, and 95.1 3.8%, respectively.ConclusionNovel VMAT planning approaches with clinical treatment planning software and linear accelerators prove capable of delivering radiation doses in excess of 360 Gy BED10 to tumor subvolumes, while maintaining safe OAR doses.
Hierarchically Porous Bio‐Based Sustainable Conjugate Sponge for Highly Selective Oil/Organic Solvent Absorption
Authors: Ramakrishnan Rohith K. , Padil Vinod V. T. , Škodová Marcela , Wacławek Stanisław , Černík Miroslav , Agarwal Seema 
Published: February 2021

AbstractThis paper describes a novel conjugate biodegradable sponge based on the tree gum kondagogu with excellent selective oil/organic solvent absorption ability. The conjugate sponge is made hydrophobic (water contact angle 133°) by post‐process vapor phase silylation, has porosity of ≈94% with very low density (18.4 mg cm−3). The sponge can absorb selectively up to 19–43 times its weight of oils and organic solvents. Meanwhile, good reusability is also observed in up to at least 10 cycles. The biodegradation behavior is studied from BOD (biological oxygen demand) analysis, where the non‐silylated and silylated sponges degraded over 28 days by 92% and 76%, respectively, in waste‐water sludge. The novel conjugate bio‐based and biodegradable sponge used in this study is a promising sustainable material for clearing oil spills and for water treatment.
Recent Advances on Multivalued Logic Gates: A Materials Perspective
Authors: Jo Sae Byeok , Kang Joohoon , Cho Jeong Ho 
Published: February 2021

AbstractThe recent advancements in multivalued logic gates represent a rapid paradigm shift in semiconductor technology toward a new era of hyper Moore's law. Particularly, the significant evolution of materials is guiding multivalued logic systems toward a breakthrough gradually, whereby they are transcending the limits of conventional binary logic systems in terms of all the essential figures of merit, i.e., power dissipation, operating speed, circuit complexity, and, of course, the level of the integration. In this review, recent advances in the field of multivalued logic gates based on emerging materials to provide a comprehensive guideline for possible future research directions are reviewed. First, an overview of the design criteria and figures of merit for multivalued logic gates is presented, and then advancements in various emerging nanostructured materials—ranging from 0D quantum dots to multidimensional heterostructures—are summarized and these materials in terms of device design criteria are assessed. The current technological challenges and prospects of multivalued logic devices are also addressed and major research trends are elucidated.
The heat never bothered me anyway: Gender‐specific response of agricultural labor to climatic shocks in Tanzania
Authors: Lee Yeyoung , Haile Beliyou , Seymour Greg , Azzarri Carlo 
Published: February 2021

AbstractAgricultural production in Africa is generally highly labor intensive with gender‐specific specialization across activities. Using panel data from Tanzania, we examine the effects of heat stress (temperature above 29°C) during the maize‐growing season on gender‐disaggregated agricultural labor use. Results show that heat stress reduces total male family labor but does not statistically affect female family labor. Households with only female adults seem to increase their labor supply under heat stress. Given these heterogeneous effects, gender‐sensitive development interventions and adaptation strategies are suggested to enhance women's adaptive capacity.
14q32.11 microdeletion including CALM1, TTC7B, PSMC1, and RPS6KA5: A new potential cause of developmental and language delay in three unrelated patients
Authors: Eno Celeste C. , Graakjaer Jesper , Svaneby Dea , Nizon Mathilde , Kianmahd Jessica , Signer Rebecca , Martinez‐Agosto Julian A. , Quintero‐Rivera Fabiola 
Published: February 2021

AbstractThree unrelated patients with similar microdeletions of chromosome 14q32.11 with shared phenotypes including language and developmental delay, and four overlapping genes ‐CALM1, TTC7B, PSMC1, and RPS6KA5 have been presented. All four genes are expressed in the brain and have haploinsufficiency scores, which reflect low tolerance to loss of function variation. An insight on the genes in the overlapping region, which may influence the resulting phenotype has been provided. Given the three patients' similar phenotypes and lack of normal variation in this region, it was suggested that this microdeletion may be associated with developmental and language delay.
Copper‐Catalyzed Tandem Cross‐Coupling/Annulation of Phenols with Ketoximes through Dual C−H Functionalization: Synthesis of Substituted 2‐Aryl‐1H‐indoles
Authors: Wang Huan , Xie Ying , Li Yulong , Yang Yi , Long Jilan , Zhang Hao 
Published: February 2021

AbstractA copper‐catalyzed cascade synthesis of substituted 2‐aryl‐1H‐indoles from phenols and oximes is developed. This reaction involves dual C−H bond cleavage of phenols and cyclization with oximes and proceeds smoothly under mild conditions without any additives.
Parawasserstoff‐induzierte Polarisation von Aminosäuren
Authors: Pravdivtsev Andrey N. , Buntkowsky Gerd , Duckett Simon B. , Koptyug Igor V. , Hövener Jan‐Bernd 
Published: February 2021

AbstractDie Kernspinresonanz (NMR) hat sich zu einer universellen Methode für biochemische und biomedizinische Studien, einschließlich Metabolomik, Proteomik und Magnetresonanztomographie (MRT), entwickelt. Durch die Vervielfachung des NMR‐Signals ausgewählter Moleküle hat die Kernspin‐Hyperpolarisation das Anwendungsspektrum von NMR und MRT bedeutsam erweitert (z. B. hyperpolarisierte Festkörper‐NMR und metabolische Bildgebung in vivo). Parawasserstoff (pH2) erlaubt es, Moleküle schnell und kostengünstig zu hyperpolarisieren. In diesem Gebiet wurden in den letzten zehn Jahren umfangreiche Fortschritte erzielt, einschließlich der Synthese neuer Tracer, Katalysatoren und Methoden für die Polarisationsübertragung. Das Portfolio an hyperpolarisierten Molekülen umfasst nunmehr Aminosäuren, die für viele Anwendungen von großem Interesse sind. In diesem Beitrag beleuchten wir die aktuelle Literatur zur Hyperpolarisation von Aminosäuren und Peptiden.
Boosting Electrocatalytic Activity of 3d‐Block Metal (Hydro)oxides by Ligand‐Induced Conversion
Authors: Liu Wenxian , Zheng Dong , Deng Tianqi , Chen Qiaoli , Zhu Chongzhi , Pei Chengjie , Li Hai , Wu Fangfang , Shi Wenhui , Yang Shuo‐Wang , Zhu Yihan , Cao Xiehong 
Published: February 2021

AbstractThe 3d‐transition‐metal (hydro)oxides belong to a group of highly efficient, scalable and inexpensive electrocatalysts for widespread energy‐related applications that feature easily tailorable crystal and electronic structures. We propose a general strategy to further boost their electrocatalytic activities by introducing organic ligands into the framework, considering that most 3d‐metal (hydro)oxides usually exhibit quite strong binding with reaction intermediates and thus compromised activity due to the scaling relations. Involving weakly bonded ligands downshifts the d‐band center, which narrows the band gap, and optimizes the adsorption of these intermediates. For example, the activity of the oxygen evolution reaction (OER) can be greatly promoted by ≈5.7 times over a NiCo layered double hydroxide (LDH) after a terephthalic acid (TPA)‐induced conversion process, arising from the reduced energy barrier of the deprotonation of OH* to O*. Impressively, the proposed ligand‐induced conversion strategy is applicable to a series of 3d‐block metal (hydro)oxides, including NiFe2O4, NiCo2O4, and NiZn LDH, providing a general structural upgrading scheme for existing high‐performance electrocatalytic systems.
Two‐Dimensional Design Strategy to Construct Smart Fluorescent Probes for the Precise Tracking of Senescence
Authors: Gao Ying , Hu Yulu , Liu Qimeng , Li Xiaokang , Li Xinming , Kim Chu‐Young , James Tony D. , Li Jian , Chen Xi , Guo Yuan 
Published: February 2021

AbstractThe tracking of cellular senescence usually depends on the detection of senescence‐associated β‐galactosidase (SA‐β‐gal). Previous probes for SA‐β‐gal with this purpose only cover a single dimension: the accumulation of this enzyme in lysosomes. However, this is insufficient to determine the destiny of senescence because endogenous β‐gal enriched in lysosomes is not only related to senescence, but also to some other physiological processes. To address this issue, we introduce our fluorescent probes including a second dimension: lysosomal pH, since de‐acidification is a unique feature of the lysosomes in senescent cells. With this novel design, our probes achieved excellent discrimination of SA‐β‐gal from cancer‐associated β‐gal, which enables them to track cellular senescence as well as tissue aging more precisely. Our crystal structures of a model enzyme E. coli β‐gal mutant (E537Q) complexed with each probe further revealed the structural basis for probe recognition.
Evaluating the distribution of priority benthic habitats through a remotely operated vehicle to support conservation measures off Linosa Island (Sicily Channel, Mediterranean Sea)
Authors: Romagnoli Beatrice , Grasselli Ferrante , Costantini Federica , Abbiati Marco , Romagnoli Claudia , Innangi Sara , Di Martino Gabriella , Tonielli Renato 
Published: February 2021

Abstract

Explorations of the Mediterranean deep sea using remotely operated vehicles have shown that the sea bed hosts rich habitats, supporting high biodiversity. However, there have been only a few studies dealing with the southern part of the basin, leading to limited protection and conservation efforts in this area.
This study aimed to explore the sea bed off Linosa Island (Sicily Channel, southern Mediterranean Sea), which is considered a ‘sentinel area’ for alien species and global environmental changes owing to its geographic position, thus deserving special attention.
Remotely operated vehicle surveys, carried out in 2016 and 2017, were analysed to provide the first ecological characterization of benthic assemblages at depths −19 – −384 m around Linosa Island.
Communities were dominated by three priority habitats, amounting to 39% of the almost 5 km of the sea floor that was surveyed. These are represented in the euphotic zone by Posidonia oceanica meadows and, at greater depth, by newly discovered dense coral forests and extended rhodolith/maërl beds. Sixteen habitat‐forming species included in the Red List of the International Union for Conservation of Nature (e.g. gorgonians Eunicella cavolini and Paramuricea clavata, and black corals Antipathella subpinnata and Leiopathes glaberrima) were recorded, as well as individuals of Sargassum sp. at −100 m depth.
The volcanic island of Linosa represents a small, naturally preserved area, with very limited human pressure, hosting rich marine benthic biodiversity. Given the high species and habitat richness, we recommend its inclusion in the Special Protected Areas of Mediterranean Importance project (United Nations Environment Programme) and suggest a redefinition of the existing marine protected area extension.
Productivity improvement and charge variant modulation for intensified cell culture processes by adding a carboxypeptidase B (CpB) treatment step
Authors: Xu Jianlin , Zheng Shun , Dawood Zeinab , Hill Charles , Jin Weixin , Xu Xuankuo , Ding Julia , Borys Michael C. , Ghose Sanchayita , Li Zheng Jian , Pendse Girish 
Published: February 2021

AbstractThe goal of cell culture process intensification is to improve productivity while maintaining acceptable quality attributes. In this report, four processes, namely a conventional manufacturing Process A, and processes intensified by enriched N‐1 seed (Process B), by perfusion N‐1 seed (Process C), and by perfusion production (Process D) were developed for the production of a monoclonal antibody. The three intensified processes substantially improved productivity, however, the product either failed to meet the specification for charge variant species (main peak) for Process D or the production process required early harvest to meet the specification for charge variant species, Day 10 or Day 6 for Processes B and C, respectively. The lower main peak for the intensified processes was due to higher basic species resulting from higher C‐terminal lysine. To resolve this product quality issue, we developed an enzyme treatment method by introducing carboxypeptidase B (CpB) to clip the C‐terminal lysine, leading to significantly increased main peak and an acceptable and more homogenous product quality for all the intensified processes. Additionally, Processes B and C with CpB treatment extended bioreactor durations to Day 14 increasing titer by 38% and 108%, respectively. This simple yet effective enzyme treatment strategy could be applicable to other processes that have similar product quality issues.