bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finite element analysis of the optimal configuration of bridging combined internal fixation system in the treatment of vancouver B1 periprosthetic femoral fractures.
Authors: Zhang Long , Haque Md Ariful , Xiong Ying , Qin Jing , Liu Luyun , Zhang Yingjie , Xiao Jiayu 
Published: September 2021

Abstract
Background and Objective: The incidence of periprosthetic fracture increases with the increase of total hip arthroplasty. The treatment of periprosthetic fracture is always a difficult point. The bridged combined internal fixation system (Ortho-bridge System, OBS) is well adapted to the characteristics of periprosthetic fractures.In this study, finite element analysis was used to evaluate the optimal configuration of OBS for fixation of Vancouver B1 periprosthetic femoral fractures.Methods: A three-rod combination OBS fixation model was established to evaluate the optimal position of the third rod, the cross Angle of proximal screws, the diameter of the connecting rod, and the number of screws. Femoral displacement and the maximum Von Mises (equivalent) stress of OBS were used as evaluation indexes.Results: The third rod is located at 35mm below the lateral fovea of the femur and the minimum Von Mises peak stress of OBS, which is the best location for placing the third rod. It is feasible for proximal screw intersection Angle to be about 71° and 84°.To fix the strength, the 6mm connecting rod is better. Considering the number of screws scheme comprehensively, scheme D is the best number of screws scheme.Conclusion: The personalized and diversified fixation mode of OBS is well adapted to the characteristics of periprosthetic fracture and provides an effective means for the treatment of periprosthetic femoral fracture.Statement : I confirm that this manuscript has not been published or presented elsewhere in part or entirety and is not under consideration by another journal. However, you may notice that a preprint has been published in research square https://www.researchsquare.com/article/rs-661745/v1, “Finite element analysis of the optimal configuration of bridging combined internal fixation system in the treatment of Vancouver B1 periprosthetic femoral fractures”. But it's not published or under consideration by any journal.
Geo-Environmental Quality Assessment Study Based On Multivariate Data And Geospatial Approach For A Watershed of Central India
Authors: Doad Atul P. , Das Sandipan , Khadse S.P. , Khare Y.D. , Pande Chaitanya B. , Varade Abhay Mukund 
Published: September 2021

Abstract
The present study accentuates the expediency of remote sensing (RS), Geographical Information System (GIS), and Spatial Multiple Criteria Evaluation Analysis (SMCE) in appraising the geo-environmental scenario of a watershed falling under the semi-arid region of India. In this study, the Bordi river basin, which falls partly under the Amravati and the Akola districts of Maharashtra state, Central India has been investigated in detail for identifying the existing environmental status of the region. This natural resource evaluation technique incorporates a set of 10 parameters which has significance in regional geo-environment sustainability. In the process, using expert knowledge, an integrated geo-environmental potential index (GPI) has been calculated and the same is used further to derive the final geo-environmental potential map (GEPM) illustrating four classes of geo-environmental resources i.e. high, moderate, low, and poor. The geo-environmental quality map overall shows a high level of geo-environmental resources in the maximum area (48.30%). The results are significant in protection, conservation, and planning management strategies of the geo-environment of the study area. Each geo-environmental potential unit is amenable to specific conservation techniques and hence appropriate conservation techniques are recommended to each of them. The work amply proves the applicability of RS, GIS, and SMCE techniques in the natural resource evaluation procedure. This technique is found to be suitable for areas with similar geo-environmental set-up elsewhere.
The continuity of prime numbers can lead to even continuity
Authors: Ling Xie 
Published: September 2021

Abstract
n continuous prime numbers can combine a group of continuous even numbers. If an adjacent prime number is followed, the even number will continue.For example, if we take prime number 3, we can get even number 6. If we follow an adjacent prime number 5, we can get even numbers by using 3 and 5: 6, 8 and 10.If a group of continuous prime numbers 3,5,7,11,... P, we can get a group of continuous even numbers 6,8,10,12,..., 2n. Then if an adjacent prime number q is followed, the original group of even numbers 6,8,10,12,..., 2n will be finitely extended to 2 (n + 1) or more adjacent even numbers. My purpose is to prove that the continuity of prime numbers will lead to even continuity as long as 2 (n + 1) can be extended.If the continuity of even numbers is discontinuous, it violates the Bertrand Chebyshev theorem of prime numbers.Because there are infinitely many prime numbers: 3, 5, 7, 11,...We can get infinitely many continuous even numbers: 6,8,10,12,...
Location, Location, Location: A Discrete Choice Experiment to Inform Vaccination Programme Delivery in the UK
Authors: McPhedran Robert , Gold Natalie , Bemand Charlotte , Weston Dale , Rosen Rachel , Scott Robert , Chadborn Tim , Amlôt Richard , McMaster Toby , Kume-Holland Charlotte , Mawby Max , Toombs Ben 
Published: September 2021

Abstract
BackgroundLarge-scale vaccination is fundamental to combatting COVID-19. In March 2021, the UK’s vaccination programme had delivered vaccines to large proportions of older and more vulnerable population groups; however, there was concern that uptake would be lower among young people. This research was designed to elicit the preferences of 18-29-year-olds with respect to key delivery characteristics.MethodsFrom 25 March - 2 April 2021, an online sample of 2,021 UK adults aged 18-29 years participated in a Discrete Choice Experiment. Participants made six choices, each between two SMS invitations to get vaccinated; each choice also had an opt-out. Each invitation had four attributes (1 x 5 levels, 3 x 3 levels): delivery mode, appointment timing, proximity, and SMS sender. These were systematically varied according to a d-optimal fractional factorial design. Order of presentation was randomised for each participant. Responses were analysed using a mixed logit model.ResultsThe logit model revealed a large alternative-specific constant (β = 1.385, SE = 0.067, p <0.001), indicating a strong preference for ‘opting in’ to appointment invitations. Pharmacies were dispreferred to the local vaccination centre (β = -0.256, SE = 0.072, p <0.001), appointments in locations that were 30-45 minutes travel time from one’s premises were dispreferred to locations that were less than 15 minutes away (β = -0.408, SE = 0.054, p <0.001), and, compared to invitations sent by the NHS, SMSs forwarded by ‘a friend’ were dispreferred (β = -0.615, SE = 0.056, p <0.001) but invitations from the General Practitioner were preferred (β = 0.105, SE = 0.048, p = 0.028).ConclusionsThe results indicated that the existing configuration of the UK’s mass vaccination programme was well-placed to deliver vaccines to 18-29-year-olds; however, some adjustments might enhance acceptance. Local pharmacies were not preferred; long travel times were a disincentive but close proximity (0-15 minutes from one’s premises) was not necessary; and either the ‘NHS’ or ‘Your GP’ would serve as adequate invitation sources. This research informed COVID-19 policy in the UK, and contributes to a wider body of Discrete Choice Experiment evidence on citizens’ preferences, requirements and predicted behaviours regarding COVID-19.
Effect of Treatment With Gonadoreline at the Embryo Transfer on Pregnancy Outcomes in Bovine.
Authors: Defensor Melissa Lobato , Faria Ana Cláudia Fagundes , Marques Flávio Luiz Alves , Cadima Gustavo Pereira , Mafra Mayara Oliveira , Santos Ricarda Maria dos 
Published: September 2021

Abstract
The aim of this study was to assess whether administration of the gonadotropin-releasing hormone (GnRH) agonist gonadorelin would increase conception rates at 30 (P / ET 30) and 60 (P / ET 60) days of gestation and reduce pregnancy losses (PL) in embryo recipients and what would be the correlation between the animal category and the season of the year in which the embryo transfer would occur. The experiment was conducted on 11 commercial farms in the state of Minas Gerais, Brazil. Recipients were randomly divided into groups: treated (n = 624), cows that received 0.1 mg gonadorelin on the day of FTET, and control (n = 687), untreated cows. All embryos were produced in vitro from oocyte donors of different races. Recipients were classified as heifers, dry cows or lactating cows. Higher conception rate was observed at 30 days (p = 0.03) and 60 days (p = 0.01) in the treated group (45.8%; 43.0%, respectively). Dry and lactating cows had less pregnancy loss (p = 0.001) compared to heifers (2.70% and 2.47% vs 10.42%, respectively). During spring/summer, there was less P/FTET at 30 days (0.024). Embryo transfer carried out in the warmer seasons of the year reduced the pregnancy rate to 60 days and increased pregnancy loss. As an implication, the use of the GnRH analogue can be used as a tool to increase fertility in embryo recipients.
Direct Orange 26 Dye Environmental Degradation: Experimental Studies (UV, Mass and Thermal) in Comparison With Computational Exploration Hydrogen Bonding Analysis of TD-DFT Calculations
Authors: Abo-Ayad Zahraa A. M. , Zayed Mohamed A. , Noamaan Mahmoud A 
Published: September 2021

Abstract
The importance of this study stems from, it concentrates on new approach applying both practical and theoretical aspects to study structure stability of Direct orange dye 26 (DO26) as an important dye widely used for dyeing of cotton or viscose for red orange direct printing. The stable dyes are so difficult to remove, decolorized and/ or degrade, in pure solution or in wastewater samples, without using powerful removal environmental techniques electrochemical oxidations suggest and efficiently used in our Lab. Therefore, it is very important to compare between practical thermal and mass results as efficient techniques in studying dye stability, in comparison with theoretical results using Gaussian program for structural stability identification of DO26 dye, via careful inspection of various phenomena detected in its two symmetrical arms around urea center. Direct orange dye 26 (DO26) structure has been studied applying both practical spectroscopic and theoretical investigations. DFT-B3LYP/6-311++G(d,p) calculations and the electronic vibrational properties are performed to investigate its structure stability and consequently its degradation and removal from its environmental media. Correlation is found between experimental and calculated data. An intra-molecular hydrogen bonding interaction had been detected and characterized in dye skeleton. The hydrogen bonding present in the dye structure affecting its vibrational properties had been discussed. Natural population analysis like HOMO and LUMO and high quality molecular electrostatic potential plots along with various electronics had been presented at the same level of theory. Chemical reactivity descriptors from conceptual density functional theory point of view, structure activity relationship descriptor were obtained. The experimental UV/Visible, FT-IR, mass and GC-mass spectral data of the dye DO26 (D1) had been presented. These data had been supported by TD-DFT calculations to simulate the experimental spectra with computing the natural transition orbitals (NTO) and the orbital composition. The variation of charge transfer length (Δr) and variation in its dipole moment with respect to ground state (ΔmCT) had been computed in order to study the charge redistribution due to the excitations. Actually there is a problem that, degradation of this dye in wastewater by different techniques leads to various unknown fragments but on using theoretical possibilities it can be expected what happened in practical work.
Comparison of Progestin-Primed Ovarian Stimulation Regimen and Antagonist Regimen in Diminished Ovarian Reserve Patients Over 35 Years of Age
Authors: Wang Mohan , Wang Ruixue , Xi Qi , Jiang Yuting , Zhang Hongguo , Liu Ruizhi 
Published: September 2021

Abstract
Background

the aim of this study was to compare the efficacy of progestin-primed ovarian stimulation (PPOS) regimen and GnRH antagonist regimen in infertile patients older than 35 years with diminished ovarian reserve (DOR).
Methods

a retrospective cross-sectional study of 196 in vitro fertilization (IVF) cycles between January 2016 and January 2020 was performed. The measured outcomes included the number of retrieved oocytes, incidence of premature LH surge, laboratory indicators and frozen embryo transfer (FET) outcome.
Results

the number of oocytes retrieved in the antagonist group was higher than those in the PPOS group (p < 0.05). Incidence of premature LH surge in two groups showed no difference (p > 0.05). E2 and P on HCG administration day of antagonist group were higher than those of PPOS group (p < 0.05). And there was no significant difference between two groups of FET outcome indicators (p > 0.05).
Conclusions

for DOR patients over 35 years of age, antagonist regimen would retrieve more oocytes than PPOS regimen. Therefore, from the perspective of oocyte retrieving, the antagonist regimen might be more suitable for DOR patients over 35 years old.
Morphological Stability of Rural Populations Confirms Their Use As Controls in Urban Ecology Studies
Authors: Regacho Tania , delBarco-Trillo Javier 
Published: September 2021

Abstract
The expansion of urban environments and how animals may be affected by them are being increasingly investigated, leading to a surge in urban ecology studies. Many urban ecology studies involve a direct comparison between rural and urban populations, or the use of urban gradients along a continuum from rural to urban areas. The implicit, although not properly investigated, assumption in these rural vs urban comparisons is that the rural populations offer a control that represents a lack of the anthropogenic stressors affecting the urban populations. Here we used museum skulls from 14 rodent species to conduct two separate studies, measuring fluctuating asymmetry (FA) as a proxy of developmental stress to assess the effect of anthropogenic disturbance. First, we compared urban and rural specimens of house mice (Mus musculus) to validate our methodological approach. Second, we compared rural specimens from 14 rodent species collected during the last two centuries across Austria. We hypothesised that FA in rural populations has not increased over the last two centuries, which would support the use of rural populations as a proper control in rural vs urban comparisons. We found higher morphological asymmetry in urban populations of Mus musculus compared to rural populations, which is consistent with similar studies in other species. However, we did not find any significant increase in FA over time in rural populations for any of the studied species. This supports the common practice of using rural populations as a control in rural vs urban comparisons when assessing the effects of urbanisation.
Differential Responses of Community Nonstructural Carbohydrate to Drought Manipulation Along a Natural Aridity Gradient
Authors: Song Lin , Luo Wentao , Griffin-Nolan Robert J. , Ma Wang , Cai Jiangping , Zuo Xiaoan , Yu Qiang , Hartmann Henrik , Li Mai-He , Smith Melinda D. , Collins Scott L. , Knapp Alan K. , Wang Zhengwen , Han Xingguo 
Published: September 2021

Abstract
Plant nonstructural carbohydrates (NSC) can reflect community and ecosystem responses to environmental changes such as water availability. Climate change is predicted to increase aridity and the frequency of extreme drought events in grasslands, but it is unclear how community-scale NSC will respond to drought or how such responses may vary along aridity gradients. We experimentally imposed a 4-year drought in six grasslands along a natural aridity gradient and measured the community-weighted mean of leaf soluble sugar (SSCWM) and total leaf NSC (NSCCWM) concentrations. We observed a bell-shape relationship across this gradient, where SSCWM and total NSCCWM concentrations were lowest at intermediate aridity, with this pattern driven primarily by species turnover. Drought manipulation increased both SSCWM and total NSCCWM concentrations at intermediately arid grassland but decreased total NSCCWM concentrations at one site. These differential responses to experimental drought depended on the relative role of species turnover and intraspecific variation in driving SSCWM and total NSCCWM. Specifically, the synergistic effects of species turnover and intraspecific variation driven the responses of leaf NSC concentrations to drought, while their antagonistic effects diminished the effect of drought on plant SSCWM and total NSCCWM concentrations. Plant resource strategies were more acquisitive, via increasing chlorophyllCWM content, to offset reduced NSCCWM concentrations with increasing aridity at drier sites, but more conservative (i.e., decreased plant heightCWM) to reduce NSC consumption at more mesic sites. The relationship between water availability and NSCCWM concentrations may contribute to community drought resistance and improve plant viability and adaptation strategies to a changing climate.
Therapeutic Effects and Central Mechanism of Acupuncture and Moxibustion for Treating Functional Dyspepsia: Study Protocol for An fMRI-Based Randomized Controlled Trial
Authors: Zhang Pan , Yin Tao , Mao Yang-Ke , He Zhao-Xuan , Yang Sha , Huang Si-Qin , Sun Rui-Rui , Zeng Fang 
Published: September 2021

Abstract
Background: Functional dyspepsia (FD) is one of the most common functional gastrointestinal disorders, with a high prevalence and significant influence on the quality of life (QoL). Either acupuncture or moxibustion is effective for dyspepsia, which is confirmed by both ancient documents and modern research. However, the therapeutic advantage and underlying mechanism between acupuncture and moxibustion for FD remain unclear. Methods: This randomized controlled fMRI trial aims to (i) evaluate the therapeutic advantages of acupuncture and moxibustion treatment for FD; (ii) investigate the similarities and differences in cerebral activity elicited by acupuncture and moxibustion; and (iii) analyze the possible correlations between brain responses and clinical variables thus to explore the potential central mechanism of acupuncture and moxibustion for treating FD. Ninety-two FD patients will be randomly assigned to either the acupuncture group or the moxibustion group in a 1:1 ratio. Twenty sessions of acupuncture or moxibustion treatment over 4 weeks will be performed on each patient. The short form Leeds Dyspepsia Questionnaire, the Nepean Dyspepsia Index, etc. are used to evaluate the therapeutic effects. The Heart Rate Variability will be analyzed to investigate the autonomic nerve function. Thirty-six FD patients in each group will be randomly selected for the fMRI scan to detect cerebral activity changes. Discussion: We expect the results will deepen our knowledge on the clinical value and underlying mechanism of acupuncture and moxibustion, and provide a reference for a better selection of interventions for treating FD.Trial Registration: Chinese Clinical Trial Registry (www.chictr.org.cn), ChiCTR2100049496 (registration date: 2nd August, 2021).
A Study on a New Index of Vascular Stiffness: Gender Difference and Risk Factors
Authors: Chen Jianxiong , Wu Xiuqin , Hong Yongqiang , Xie Yuchen , Liang Fuyou , Luo Xianghong , Li Zhaojun 
Published: September 2021

Abstract
Background: Previous studies have found that the gender differences have important influences on cardiovascular events, and arterial stiffness is an independent risk factor for cardiovascular events. The arterial pressure volume index (API) is a new indicator for the noninvasive assessment of muscular arterial stiffness. This study was aimed to preliminarily investigate on the gender differences and influencing factors of API from Chinese people, and to discuss the practical application implications of it.Methods: A total of 11118 outpatients were randomly selected and divided into 5 groups according to the age from low to high quintile (Q1: < 37 years old group, Q2: ≥ 37 years old group, Q3: ≥ 51 years old group, Q4: ≥ 61 years old group and Q5: ≥ 69 years old group). The API was obtained by using the cuff oscillation wave for every subject. API≥31 was defined as high API, and body mass index (BMI)≥24 kg/m2 was diagnosed as overweight. The differences of API and high API incidence between male and female subjects in the five groups were compared by Pearson correlation analysis. The risk factors of high API incidence were analyzed by multivariate logistic regression. Results: ①The differences in API and systolic blood pressure(SBP) between the 5 groups were statistically significant, and they increased with age (all P<0.001).②In the Q1 groups, the API of female was lower than that of male, while the API of female subjects was greater than that of male in the Q3 to Q5 group (P<0.05). The incidence of high API was higher in male than in female (P<0.05) in the Q1 group, but the incidence of high API was higher in female than in male (P<0.05) in the Q3 to Q4 groups. ③Logistic regression model indicated that the risk of high API for male subjects was 0.712 times that of female subjects (95%CI: 0.584, 0.840) (P<0.05). The risk of high API for overweight subjects was 1.327 times that of normal weight subjects (95%CI: 1.236, 1.418) (P<0.05). Conclusion: Among Chinese people of different ages, API differed between male and female; in the whole subjects, the risk of high API is higher for female subjects and overweight subjects.
Biallelic Mutations in WDR12 is Associated With Male Infertility With Tapered-Head Sperm
Authors: hua juan , Guo Lan , Yao Yao , Wan Yangyang , Hu Wen , Jiang Hui , Zhang Xiansheng , Xu Bo 
Published: September 2021

Abstract
Teratozoospermia is a rare disease associated with male infertility. Unfortunately, approximately 30% of the genetic causes associated with teratozoospermia remain unknown. Several recurrent genetic mutations have been reported to be associated with globozoospermia, macrozoospermia and acephalic spermatozoa, whereas the genetic basis of tapered-head sperm is relatively less well-understood. In this study, whole-exome sequencing (WES) identified a homozygous WD repeat domain 12 (WDR12) (p.Ser162Ala/c.484T>G) variant in an infertile patient with tapered-head sperm from a consanguineous Chinese family. Bioinformatic analysis predicted this mutation to be a pathogenic variant. To further verify the effect of this variant, we analyzed WDR12 protein expression in the patient’s spermatozoa by western blot and found WDR12 to be significantly down-regulated. Also, we found that WDR12 expression is increased in pachytene spermatocytes, and intense staining was visible throughout the round spermatids in mouse testis. Based on our results, we concluded that a rare biallelic pathogenic missense variant (p.Ser162Ala/c.484T>G) in the WDR12 gene causes teratozoospermia. These results will provide novel insights into understanding the molecular mechanisms of male infertility and will help clinicians provide accurate diagnoses.