bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of preschoolers’ musical abilities by means of the K. Orff's method: theoretical aspects
Authors: Mkrtichian Oksana 
Published: August 2021

The article reveals the problem of forming a comprehensively developed child’s personality by means of musical art. The development of the child, his or her formation as a person is a significant problem of preschool education. One of the ways to achieve this goal is to involve children in the process of music education, which has a great impact on child development. The purpose of the article is to reveal the influence of the Karl Orff’s concept of music education on the preschoolers’ musical abilities. Research methods at the scientific and theoretical level include: method of analysis – the analysis of scientific and methodological literature, methods of teaching music, methods of synthesis and generalization; system analysis – to display the basic components of the methodology.
The results. On the basis of the conducted analysis, the principles of the pedagogical approach of Karl Orff and features of aesthetic education of children in the conditions of the given system were defined. Since preschool education requires new approaches in the context of the development of preschoolers by means of musical art, it is advisable to introduce the K. Orff’s method in the educational process of preschool institution. Moreover it is proved that the presence of music in the educational process opens opportunities for the harmonious development of preschool children. K. Orff’s musical and pedagogical approach is a concentrated carrier of the ideas of humanistic pedagogy, pedagogy of the freedom of creative personality.
Conclusions. K. Orff’s method is spreading and influencing the music education of Ukraine, involving Ukrainian culture in the educational process, using folk and children’s songs, elementary music, which is an act of elementary self-expression, to which man is adapted by nature. Consequently, the K. Orff’s methods is universal, flexible and open, which allows us to combine its principles with various methods of music education, which is spread and successfully used in preschool institution; and the creation of special pedagogical conditions, the use of aesthetic techniques and musical means in the classroom with the active participation of children helps them to keep the dominance of positive emotions, significantly increases motivation for learning and music, has an effective impact on motor, speech, communication and psychological development.
Chinese empire or a prototype of responsible global power: discussions on the Great Qing in China and the West
Authors: Sanin Konstantin A. 
Published: August 2021

In the light of China’s rise, it is of great interest to consider the views that are widespread in the PRC on the nature of Chinese state and the proper mode of international relations. Considering that Chinese leadership has proclaimed the goal of &quot;rejuvenation&quot; of the Chinese nation, modern assessments of China&apos;s historical past allow us to take a fresh look at the prospects for China&apos;s internal development as well as Chinese foreign policy in Asia. In this regard the era of the Qing Dynasty is of particular interest. During that period Chinese territory expanded approximately to its modern borders, and the relations with the neighbors underwent a transition from the tributary system to the modern Westphalian type of international relations.
There exist various interpretations of Chinese foreign policy’s traditions. Those interpretations are largely determined by the attitude to China&apos;s current behavior at the international stage. While the Chinese rulers have adopted the concept of traditional Chinese world order that is of Western origin, many Western researchers nowadays question this concept and tend to describe pre-revolutionary China as one of many expansionist empires in Eurasia. That point of view is subject to sharp criticism from Chinese authors. The portrayal of Qing China as one of the empires can entail serious consequences for international relations as well as the territorial integrity of the PRC.
In order to achieve their goals in domestic and foreign policy, Chinese leaders strive to build a historical narrative in such a way that it combines the elements of various historical periods which are most profitable in the current circumstances, including the history of Silk Road.
Social Peculiarities of the Family Planning Problem in Tropical Africa
Authors: Rybalkina Inna G. 
Published: August 2021

The subject is reflected in the important international documents of the UN – the Millennium development Goals 2001 and the Sustainable develop-ment Goals 2015. The article examines implementing family planning pro-grams in Tropical Africa, analyzes the attitude of ruling circles and people masses to this problem in the context of centuries-old traditions of having many children, great value of free child labor in agriculture, polygyny, re-ligiosity and other socio-cultural stereotypes. Despite the efforts of interna-tional organizations, most of the 48 countries in sub-Saharan Africa are experiencing a slow spread of contraception, the birth rate is “stalling” at high rates, or the decline in fertility is slow.
But there are some positive examples of countries, where the use of con-traception reaches the 70% level recommended by international experts-demographers, and the birth rate is decreasing, approaching the replace-ment level. These countries are Ethiopia, Rwanda, Madagascar, Ghana, Kenya, and the countries of the South African region. It is likely that the success of family planning and the reduction of the birth rate are due to the consolidated approach of government circles, NGOs, private, public and international organizations, with the crucial role of international donors and financial funds.
In the course of evolutionary socio-economic development, fertility rates will decrease. But in the next decades, there will still be an increase in the population of a number of SSA countries by 2–3 times. Without substantial foreign financial assistance peoples of Africa, especially the peoples of Cen-tral and West Africa, will not be able to cope with this problem.
About Manuscripts, Lithographs and Early Printed Books of the Karakalpak Institute of Humanities
Authors: Anikeeva Tatiana A. 
Published: August 2021

In the course of work in the manuscript collection of the Karakalpak Institute of Humanities (Branch of the Academy of Sciences of the Republic of Uzbekistan), a collection of manuscripts, lithographs and old-printed books was identified. It consists mainly of new arrivals (the so-called “Chimbay collection” at the place of origin of most of the manuscripts, from the city of Chimbay, formerly Shakhtemir, now in the Republic of Karakalpakstan). According to the information of the Institute&apos;s employees, Uzak Rakhmatullayev (born in 1920 in the territory of the modern Chimbay district of Karakalpakstan) collected more than 300 manuscripts and printed publications in Arabic, Persian and Turkic languages and subsequently transferred the collection to the Institute. We started its scientific description. A preliminary list of manuscripts, lithographs, and old-printed books was compiled, and they were distributed by language, chronology and subject. Among these manuscripts are works on Muslim dogmatics, Korans, poetic works (poems by Ajiniyaz, Berdakh, Suleyman Bakyrghani, Ahmad Yasavi, various destans, etc.), treatises on the grammar of the Arabic language (“Tarkib al-Awamil”), historical works, samples of calligraphy on separate folios, etc., in Arabic, Persian and Turkic languages (Chagatai, Tatar, Karakalpak). Together, they represent the area of reading of a Muslim of that era (19-first half of the 20th century) and are one of the illustrations of the close literary and cultural ties between the Aral Sea region (then the Khanate of Khiva), the Volga region, and the Ottoman Empire (where a number of manuscripts were copied).
Inflammatory Protein Profiles in Plasma of Candidaemia Patients and the Contribution of Host Genetics to Their Variability
Authors: Matzaraki Vasiliki , Le Kieu T. T. , Jaeger Martin , Aguirre-Gamboa Raúl , Johnson Melissa D. , Sanna Serena , Rosati Diletta , Franke Lude , Zhernakova Alexandra , Fu Jingyuan , Withoff Sebo , Jonkers Iris , Li Yang , Joosten Leo A. B. , Netea Mihai G. , Wijmenga Cisca , Kumar Vinod 
Published: August 2021

Circulatory inflammatory proteins play a significant role in anti-Candidahost immune defence. However, little is known about the genetic variation that contributes to the variability of inflammatory responses in response toC. albicans. To systematically characterize inflammatory responses inCandidainfection, we profiled 91 circulatory inflammatory proteins in peripheral blood mononuclear cells (PBMCs) stimulated withC. albicansyeast isolated from 378 individuals of European origin from the 500 Functional Genomics (500FG) cohort of the Human Functional Genomics Project (HFGP) and Lifelines Deep cohort. To identify the genetic factors that determine variation in inflammatory protein responses, we correlated genome-wide single nucleotide polymorphism (SNP) genotypes with protein abundance (protein quantitative trait loci, pQTLs) produced by theCandida-stimulated PBMCs. Furthermore, we investigated whether differences in survival of candidaemia patients can be explained by modulating levels of inflammatory proteins. We identified five genome-wide significant pQTLs that modulate IL-8, MCP-2, MMP-1, and CCL3 in response toC. albicans. In addition, our genetic analysis suggested thatGADD45Gfrom rs10114707 locus that reached genome-wide significance could be a potential core gene that regulates a cytokine network uponCandidainfection. Last but not least, we observed that a trans-pQTL marked from SNP rs7651677 at chromosome 3 that influences urokinase plasminogen activator (uPA) is strongly associated with patient survival (Psurvival= 3.52 x 10-5, OR 3). Overall, our genetic analysis showed that genetic variation determines the abundance of circulatory proteins in response toCandidainfection.
Activation Phenotype of Mycobacterium tuberculosis-Specific CD4+ T Cells Promoting the Discrimination Between Active Tuberculosis and Latent Tuberculosis Infection
Authors: Luo Ying , Xue Ying , Mao Liyan , Lin Qun , Tang Guoxing , Song Huijuan , Liu Wei , Tong Shutao , Hou Hongyan , Huang Min , Ouyang Renren , Wang Feng , Sun Ziyong 
Published: August 2021

BackgroundRapid and effective discrimination between active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remains a challenge. There is an urgent need for developing practical and affordable approaches targeting this issue.MethodsParticipants with ATB and LTBI were recruited at Tongji Hospital (Qiaokou cohort) and Sino-French New City Hospital (Caidian cohort) based on positive T-SPOT results from June 2020 to January 2021. The expression of activation markers including HLA-DR, CD38, CD69, and CD25 was examined on Mycobacterium tuberculosis (MTB)-specific CD4+ T cells defined by IFN-γ, TNF-α, and IL-2 expression upon MTB antigen stimulation.ResultsA total of 90 (40 ATB and 50 LTBI) and another 64 (29 ATB and 35 LTBI) subjects were recruited from the Qiaokou cohort and Caidian cohort, respectively. The expression patterns of Th1 cytokines including IFN-γ, TNF-α, and IL-2 upon MTB antigen stimulation could not differentiate ATB patients from LTBI individuals well. However, both HLA-DR and CD38 on MTB-specific cells showed discriminatory value in distinguishing between ATB patients and LTBI individuals. As for developing a single candidate biomarker, HLA-DR had the advantage over CD38. Moreover, HLA-DR on TNF-α+ or IL-2+ cells had superiority over that on IFN-γ+ cells in differentiating ATB patients from LTBI individuals. Besides, HLA-DR on MTB-specific cells defined by multiple cytokine co-expression had a higher ability to discriminate patients with ATB from LTBI individuals than that of MTB-specific cells defined by one kind of cytokine expression. Specially, HLA-DR on TNF-α+IL-2+ cells produced an AUC of 0.901 (95% CI, 0.833–0.969), with a sensitivity of 93.75% (95% CI, 79.85–98.27%) and specificity of 72.97% (95% CI, 57.02–84.60%) as a threshold of 44% was used. Furthermore, the performance of HLA-DR on TNF-α+IL-2+ cells for differential diagnosis was obtained with validation cohort data: 90.91% (95% CI, 72.19–97.47%) sensitivity and 68.97% (95% CI, 50.77–82.73%) specificity.ConclusionsWe demonstrated that HLA-DR on MTB-specific cells was a potentially useful biomarker for accurate discrimination between ATB and LTBI.
HIV Antibody Profiles in HIV Controllers and Persons With Treatment-Induced Viral Suppression
Authors: Kammers Kai , Chen Athena , Monaco Daniel R. , Hudelson Sarah E. , Grant-McAuley Wendy , Moore Richard D. , Alter Galit , Deeks Steven G. , Morrison Charles S. , Eller Leigh A. , Blankson Joel N. , Laeyendecker Oliver , Ruczinski Ingo , Eshleman Susan H. , Larman H. Benjamin 
Published: August 2021

IntroductionLow HIV viral load is associated with delayed disease progression and reduced HIV transmission. HIV controllers suppress viral load to low levels in the absence of antiretroviral treatment (ART). We used an antibody profiling system, VirScan, to compare antibody reactivity and specificity in HIV controllers, non-controllers with treatment-induced viral suppression, and viremic non-controllers.MethodsThe VirScan library contains 3,384 phage-displayed peptides spanning the HIV proteome. Antibody reactivity to these peptides was measured in plasma from a Discovery Cohort that included 13 elite controllers, 27 viremic controllers, 12 viremic non-controllers, and 21 non-controllers who were virally suppressed on ART. Antibody reactivity to selected peptides was also assessed in an independent cohort of 29 elite controllers and 37 non-controllers who were virally suppressed on ART (Validation Cohort) and in a longitudinal cohort of non-controllers.ResultsIn the Discovery Cohort, 62 peptides were preferentially targeted in HIV controllers compared to non-controllers who were virally suppressed on ART. These specificities were not significantly different when comparing controllers versus viremic non-controllers. Aggregate reactivity to these peptides was also high in elite controllers from the independent Validation Cohort. The 62 peptides formed seven clusters of homologous epitopes in env, gag, integrase, and vpu. Reactivity to one of these clusters located in gag p17 was inversely correlated with viral load set point in an independent cohort of non-controllers.ConclusionsAntibody reactivity was low in non-controllers suppressed on ART, but remained high in viremic controllers despite viral suppression. Antibodies in controllers and viremic non-controllers were directed against epitopes in diverse HIV proteins; higher reactivity against p17 peptides was associated with lower viral load set point. Further studies are needed to determine if these antibodies play a role in regulation of HIV viral load.
CSF and Plasma Cholinergic Markers in Patients With Cognitive Impairment
Authors: Karami Azadeh , Darreh-Shori Taher , Schultzberg Marianne , Eriksdotter Maria 
Published: August 2021

IntroductionAlzheimer’s disease (AD) is the most prevalent form of dementia with symptoms of deteriorating cognitive functions and memory loss, partially as a result of a decrease in cholinergic neurotransmission. The disease is incurable and treatment with cholinesterase inhibitors (ChEIs) is symptomatic. Choline acetyltransferase (ChAT), the enzyme that synthesizes acetylcholine (ACh), has been proven recently to be present in both cerebrospinal fluid (CSF) and plasma. As ChAT plays a role in regulating the extracellular ACh levels, it may have an impact on prognosis and cognitive performance in AD patients.ObjectivesTo measure ChAT activity and its protein concentration in CSF and plasma from patients with AD, mild cognitive impairment (MCI), or Subjective cognitive impairment (SCI).MethodsPlasma and CSF samples were obtained from 21 AD, 32 MCI, and 30 SCI patients. The activity and protein levels of ChAT and acetylcholinesterase (AChE), the enzyme catalyzing the hydrolysis of ACh, were analyzed using an integrated activity and protein concentration ELISA-like assay. A Cholinergic Index was calculated as the ratio of ChAT to AChE activities in CSF. The data were analyzed in relation to dementia biomarkers and cognitive performance of the patients.ResultsThe CSF ChAT activity was significantly higher (55–67%) in MCI patients compared to AD and SCI cases. The CSF Cholinergic Index was 41 and 22% lower in AD patients than in MCI and SCI subjects, respectively. This index correlated positively with the Aβ42/p-tau ratio in CSF in SCI but negatively with that in AD and MCI. The ChAT activity and protein levels in plasma exhibited significant differences with the pattern of AD&gt;&gt;MCI&gt;SCI.ConclusionThis is the first study investigating soluble levels of the key cholinergic enzyme, ChAT, in both plasma and CSF of individuals at different clinical stages of dementia. Although further validation is needed, the overall pattern of the results suggests that in the continuum of AD, the cholinergic signaling exhibits an inverse U-shape dynamic of changes in the brain that greatly differs from the changes observed in the plasma compartment.
A Distinct Clinicopathological Feature and Prognosis of Young Gastric Cancer Patients Aged ≤ 45 Years Old
Authors: Huang Qian , Zheng Xiufeng , Jiao Yang , Lei Yanna , Li Xiaoying , Bi Feng , Guo Fukun , Wang Gang , Liu Ming 
Published: August 2021

PurposeThe aim of this retrospective study was to probe into clinicopathological features and prognosis of early-onset gastric cancer (EOGC) patients aged ≤ 45 years old.MethodsThis study selected 154 young gastric cancer patients aged ≤ 45 years old and 158 elderly gastric cancer patients aged &gt; 50 years old admitted to West China Hospital of Sichuan University in 2009-2019 as the research object. These patients were further divided into two groups according to whether tumor can be resected radically. The following parameters were analyzed: age, gender, helicobacter pylori (HP) infection status, Her-2 status, pathological type and stage, chemotherapy, tumor differentiation degree, overall survival (OS).ResultsMore than 3,000 patients with gastric carcinoma were screened, and 154 young gastric cancer patients aged ≤ 45 years old were identified as EOGC. Among them, the number of female patients in EOGC group was significantly higher than that of males, accounting for 63.6%. In addition, EOGC were associated with diffuse Laur´en type and poorly differentiated tumors. Interestingly, the Kaplan–Meier method showed that the OS of unresectable EOGC group was significantly lower than that of unresectable LOGC group (P = 0.0005) and chemotherapy containing paclitaxel tended to be more effective in the young people (P = 0.0511). Nevertheless, there was no significant difference in OS between young and elderly patients with gastric cancer in the radical resection group (P = 0.3881).ConclusionEOGC patients have a worse prognosis than late-onset gastric cancer (LOGC) patients with advanced unresectable gastric cancer. Palliative surgery or chemotherapy containing paclitaxel may improve the OS of unresectable young individuals with gastric cancer. Additional randomized controlled trials are required for guiding clinical practice.
Research on Psychache in Suicidal Population: A Bibliometric and Visual Analysis of Papers Published During 1994–2020
Authors: Cheng Yin , Zhao Wei-Wei , Chen Shu-Yan , Zhang Yan-Hong 
Published: August 2021

Background: Psychache is a negative introspective experience, which is positively associated with the risk of suicide, independently of depression. It is undeniable that psychache is an important influencing factor to trigger suicide, which can also mediate the effect between depression and suicide variables. Nevertheless, the research tendency and current hotspots on psychache of suicide population have not been systematically investigated based on bibliometric analysis.Aim: The aim of the study was to analyze the research status, hotspots, and frontiers of psychological pain in the field of suicidology, so as to provide reference for domestic clinical research.Methods: The literature related to psychache in suicide individuals published from 1994 to 2020 was included and selected from the Web of Science Core Collection database on May 28, 2021. CiteSpace (version 5.7.R2) software was used to visualize and analyze highly cited journals, authors, and articles as well as co-occurrence analysis for countries, institution, authors, and keywords.Results: A total of 230 articles from the WoS database were included. The number of papers over the years showed an overall upward trend. The United States has made the largest contribution, with the majority of publications (89, 38.70%), followed by Canada (48, 20.87%), Israel (31, 13.48%), China (20, 8.80%), and Portugal (17, 7.39%). The most productive institution was Queen's University. Edwin S. Shneidman has the largest achievement and profound influence, and the most prolific author is Ronald R. Holden. However, the cooperation between institutions and authors was comparatively weak. The current hotspots in this field focus on the studies on the relationships between depression, despair, psychache, and suicide, the risk assessments of psychological pain, and the development of psychological pain scales. Suicide and Life-Threatening Behavior was the most frequently cited journal in this field.Conclusions: This analysis not only reveals the current research trend and hotspots but also provides some instructive suggestions on the development of psychache in the suicidology. Future work should pay more attention to develop effective psychological pain intervention programs for diverse suicide population. Additionally, longitudinal study can also be conducted to grasp the trajectory changes of psychological pain among suicide individuals.
Effectiveness of eHealth Tools for Hip and Knee Arthroplasty: A Systematic Review
Authors: Mohammadi Somayyeh , Miller William C. , Wu Julia , Pawliuk Colleen , Robillard Julie M. 
Published: August 2021

Objective: This study aimed to compare the effectiveness and costs of eHealth tools with usual care in delivering health-related education to patients' undergoing total hip or knee arthroplasty due to osteoarthritis.Data Sources: Six electronic databases were searched to identify randomized controlled trials and experimental designs (randomized or not) examining the effect of eHealth tools on pre- or post-operative care. Only manuscripts written in English were included. In the current study, no specific primary or secondary outcomes were selected. Any study that investigated the impacts of eHealth tools on hip or knee arthroplasty outcomes were included.Review Methods: Two researchers reviewed all titles and abstracts independently and in duplicate. Two researchers also conducted full-text screening and data extraction from the 26 selected articles.Results: The data were descriptively reported, and themes could emerge from each outcome. Two researchers separately assessed the Risk of Bias for each paper using the Cochrane risk of bias assessment tool. The majority of studies evaluated the impact of eHealth tools on physical (n = 23) and psychosocial outcomes (n = 19). Cost-related outcomes were measured in 7 studies. eHealth tools were found to be equivocal to usual care, with few studies reporting statistically significant differences in physical or psychosocial outcome measures. However, cost-related outcomes showed that using eHealth tools is more cost-effective than usual care.Conclusions: This review demonstrated that eHealth tools might be as effective as usual care, and possibly more cost-effective, a crucial implication for many overly burdened health care systems.