bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Association of Wallerian Degeneration and Diaschisis After Ischemic Stroke With BOLD Cerebrovascular Reactivity
Authors: van Niftrik C. H. B. , Sebök M. , Muscas G. , Wegener S. , Luft A. R. , Stippich C. , Regli L. , Fierstra J. 
Published: June 2021

IntroductionWallerian degeneration and diaschisis are considered separate remote entities following ischemic stroke. They may, however, share common neurophysiological denominators, since they are both related to disruption of fiber tracts and brain atrophy over time. Therefore, with advanced multimodal neuroimaging, we investigate Wallerian degeneration and its association with diaschisis.MethodsIn order to determine different characteristics of Wallerian degeneration, we conducted examinations on seventeen patients with chronic unilateral ischemic stroke and persisting large vessel occlusion, conducting high-resolution anatomical magnetic resonance imaging (MRI) and blood oxygenation-level dependent cerebrovascular reactivity (BOLD-CVR) tests, as well as Diamox 15(O)–H2O–PET hemodynamic examinations. Wallerian degeneration was determined using a cerebral peduncle asymmetry index (% difference of volume of ipsilateral and contralateral cerebral peduncle) of more than two standard deviations away from the average of age-matched, healthy subjects (Here a cerebral peduncle asymmetry index &gt; 11%). Diaschisis was derived from BOLD-CVR to assess the presence of ipsilateral thalamus diaschisis and/or crossed cerebellar diaschisis.ResultsWallerian degeneration, found in 8 (47%) subjects, had a strong association with ipsilateral thalamic volume reduction (r2 = 0.60) and corticospinal-tract involvement of stroke (p &lt; 0.001). It was also associated with ipsilateral thalamic diaschisis (p = 0.021), No cerebral peduncular hemodynamic differences were found in patients with Wallerian degeneration. In particular, no CBF decrease or BOLD-CVR impairment was found.ConclusionWe show a strong association between Wallerian degeneration and ipsilateral thalamic diaschisis, indicating a structural pathophysiological relationship.
Prognostic Awareness in Advanced Disease: A Review Update and Concept Analysis
Authors: Kühne Franziska , Hermann Myriel , Preisler Martina , Rohrmoser Amy , Letsch Anne , Goerling Ute 
Published: June 2021

PurposeAlthough subjective knowledge about the prognosis of an advanced disease is extremely important for coping and treatment planning, the concept of prognostic awareness (PA) remains inconsistently defined. The aims of the scoping review were to synthesize a definition of PA from the most recent literature, describe preconditions, correlates and consequences, and suggest a conceptual model.MethodsBy using scoping review methodology, we searched the Web of Science and PubMed databases, and included publications, reviews, meta-analyses or guidelines on all physical diagnoses, as well as publications offering a conceptual or an operational definition of PA. The data were analyzed by means of content analysis techniques.ResultsOf the 24 included publications, 21 referred exclusively to cancer, one to patients with hip fractures and two to palliative care in general. The deduced definition of PA comprised the following facets: adequate estimation of chances for recovery, knowledge of limited time to live, adequate estimation of life expectancy, knowledge of therapy goals, and knowledge of the course of the disease. Further content analysis results were mapped graphically and in a detailed table.ConclusionThere appears to be a lack of theoretical embedding of PA that in turn influences the methods used for empirical investigation. Drawing on a clear conceptual definition, longitudinal or experimental studies would be desirable.
Consumption of Dietary Fiber in Relation to Psychological Disorders in Adults
Authors: Saghafian Faezeh , Sharif Nafiseh , Saneei Parvane , Keshteli Ammar Hassanzadeh , Hosseinzadeh-Attar Mohammad Javad , Afshar Hamid , Esmaillzadeh Ahmad , Adibi Peyman 
Published: June 2021

Background: Previous observational studies suggested a relationship between dietary fiber consumption and mental health, but the findings were conflicting. We evaluated the link between dietary fiber intake and prevalence of depression, anxiety, and psychological distress among a large population of Iranian adults.Methods: A cross-sectional study among 3,362 Iranian adults working in 50 health centers was done. Data of dietary intakes were collected through a validated semiquantitative dish-based 106-item food frequency questionnaire (FFQ). Anxiety, depression, and psychological distress were defined based on the Iranian validated version of Hospital Anxiety and Depression Scale (HADS) and General Health Questionnaire (GHQ).Results: After adjustment for potential confounders, participants in the top quartile of total dietary fiber intake had a 33% and 29% lower risk of anxiety and high psychological distress [odds ratio (OR): 0.67; 95% CI: 0.48, 0.95 and OR: 0.71; 95% CI: 0.53, 0.94, respectively] compared to the bottom quartile of intake. The highest total dietary fiber intake was also inversely related to a lower risk of depression in women (OR: 0.63; 95% CI: 0.45, 0.88) but not in men. Among overweight or obese participants, higher intake of dietary fiber was related to a decreased risk of high psychological distress (OR: 0.52; 95% CI: 0.34, 0.79). A high level of dietary fiber intake was related to a lower risk of anxiety in normal-weight individuals (OR: 0.50; 95% CI: 0.31, 0.80).Conclusion: Significant inverse associations between total dietary fiber intake with anxiety and high psychological distress were found in Iranian adults. More consumption of dietary fiber was also related to reduced odds of depression in women. More investigations with prospective nature are needed to affirm these findings.
Impact of SARS-CoV-2-Pandemic on Mental Disorders and Quality of Life in Patients With Pulmonary Arterial Hypertension
Authors: Park Da Hee , Fuge Jan , Meltendorf Tanja , Kahl Kai G. , Richter Manuel J. , Gall Henning , Ghofrani Hossein A. , Kamp Jan C. , Hoeper Marius M. , Olsson Karen M. 
Published: June 2021

Background/Objective: Covid-19 pandemic may affect mental health and quality of life (QoL) in patients with pulmonary arterial hypertension (PAH). We assessed changes in anxiety and depression, quality of life (QoL) and self-described impact of Covid-19 in patients with PAH during the Covid-19 pandemic.Methods: This study included 152 patients with PAH from two German referral centers. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS-A and HADS-D) at two different timepoints before and during the Covid-19 pandemic with a median of 232 days between baseline and follow-up. QoL was assessed using EQ-5D and emPHasis-10. Perceived impact of Covid-19 and related regulations and measures were assessed using a set of specific questions and statements.Results: More than two thirds of patients had an unsuspicious HADS-A and HADS-D. Median scores did not differ from baseline for both HADS-A and HADS-D (p = 0.202; p = 0.621). Overall, no significant changes in HADS-A or HADS-D categories from baseline to follow up were observed (p = 0.07; p = 0.13). QoL did not change between baseline and follow-up. The Covid-19 pandemic had little impact on access to medical care and established PAH therapy. Patients were in agreement with governmental measures and regulations and felt sufficiently safe.Conclusion: First waves of Covid-19 pandemic had little impact on anxiety, depression and QoL in patient with PAH. Established PAH therapy and access to medical care were not affected. Further studies on the impact of prolonged duration of the ongoing Covid-19 pandemic are needed.
Identification of Suicidal Ideation in the Canadian Community Health Survey—Mental Health Component Using Deep Learning
Authors: Desai Sneha , Tanguay-Sela Myriam , Benrimoh David , Fratila Robert , Brown Eleanor , Perlman Kelly , John Ann , DelPozo-Banos Marcos , Low Nancy , Israel Sonia , Palladini Lisa , Turecki Gustavo 
Published: June 2021

Introduction: Suicidal ideation (SI) is prevalent in the general population, and is a risk factor for suicide. Predicting which patients are likely to have SI remains challenging. Deep Learning (DL) may be a useful tool in this context, as it can be used to find patterns in complex, heterogeneous, and incomplete datasets. An automated screening system for SI could help prompt clinicians to be more attentive to patients at risk for suicide.Methods: Using the Canadian Community Health Survey—Mental Health Component, we trained a DL model based on 23,859 survey responses to classify patients with and without SI. Models were created to classify both lifetime SI and SI over the last 12 months. From 582 possible parameters we produced 96- and 21-feature versions of the models. Models were trained using an undersampling procedure that balanced the training set between SI and non-SI; validation was done on held-out data.Results: For lifetime SI, the 96 feature model had an Area under the receiver operating curve (AUC) of 0.79 and the 21 feature model had an AUC of 0.77. For SI in the last 12 months the 96 feature model had an AUC of 0.71 and the 21 feature model had an AUC of 0.68. In addition, sensitivity analyses demonstrated feature relationships in line with existing literature.Discussion: Although further study is required to ensure clinical relevance and sample generalizability, this study is an initial proof of concept for the use of DL to improve identification of SI. Sensitivity analyses can help improve the interpretability of DL models. This kind of model would help start conversations with patients which could lead to improved care and a reduction in suicidal behavior.
Inducible Selectable Marker Genes to Improve Aspergillus fumigatus Genetic Manipulation
Authors: Baldin Clara , Kühbacher Alexander , Merschak Petra , Sastré-Velásquez Luis Enrique , Abt Beate , Dietl Anna-Maria , Haas Hubertus , Gsaller Fabio 
Published: June 2021

The hygromycin B phosphotransferase gene from Escherichia coli and the pyrithiamine resistance gene from Aspergillus oryzae are two dominant selectable marker genes widely used to genetically manipulate several fungal species. Despite the recent development of CRISPR/Cas9 and marker-free systems, in vitro molecular tools to study Aspergillus fumigatus, which is a saprophytic fungus causing life-threatening diseases in immunocompromised hosts, still rely extensively on the use of dominant selectable markers. The limited number of drug selectable markers is already a critical aspect, but the possibility that their introduction into a microorganism could induce enhanced virulence or undesired effects on metabolic behavior constitutes another problem. In this context, here, we demonstrate that the use of ptrA in A. fumigatus leads to the secretion of a compound that allows the recovery of thiamine auxotrophy. In this study, we developed a simple modification of the two commonly used dominant markers in which the development of resistance can be controlled by the xylose-inducible promoter PxylP from Penicillium chrysogenum. This strategy provides an easy solution to avoid undesired side effects, since the marker expression can be readily silenced when not required.
La función social de la pena de prisión
Authors: Jongezoon Dominguez Stephen Kristofer 
Published: June 2021

El ensayo desarrollado consistió en hacer un análisis sobre la función social de la pena de prisión, para lo cual se parte por determinar esos fenómenos que tienen como consecuencia el que se cuente con un sistema carcelario deficiente, debido a la pérdida de control de las autoridades, esto porque, si bien es cierto la legislación penal guatemalteca permite la aplicación de sustitutivos penales como herramienta para la rehabilitación del delincuente sin que este necesariamente cumpla una pena de prisión en sus totalidad, en la actualidad las cárceles del país se encuentran saturadas debido al uso desmedido de las medidas privativas de libertad, lo cual ha generado que sean escuelas del crimen.
Врахування впливу коефіцієнта запасу міцності на морозостійкість при розрахунку дорожнього одягу
Authors: Ільїн Я.В. 
Published: June 2021

Встановлені в процесі досліджень закономірності показують, що коефіцієнти морозостійкості асфальтобетонів різною мірою знижуються під впливом циклічних заморожувань-відтавань. Дана робота дозволяє рекомендувати використання додаткових коефіцієнтів запасу морозостійкості при проектуванні нових автомобільних доріг з шарами нежорсткого дорожнього одягу. Для визначення необхідного показника запасу морозостійкості розглянуто дорожню конструкцію з ВБН В.2.3-218-186-2004 «Дорожній одяг нежорсткого типу». З цієї конструкції взято модулі пружності асфальтобетонів верхніх шарів та розраховано зміну коефіцієнтів запасу міцності з урахуванням зміни модулів під дією циклічних заморожувань-відтавань.
DEVELOPMENT OF GEORGIA'S TRADE RELATIONS WITH UKRAINE
Authors: GRIGOL GLUNCHADZE GRIGOL GLUNCHADZE 
Published: June 2021

The title of the article - "Development of Georgia's Trade Relations with Ukraine" shows Georgia's trade relations with Ukraine. According to the information presented in the article, which is spread over the years 2016-2020, in this 5-year period, the total trade turnover and export-import are increasing, which does not apply to the last 2020. This year, all the above indicators have been reduced - turnover by 9%, exports - by 13%, imports - by 6%. The author connects this situation with the cooling of diplomatic relations between the two countries. Because of Saakashvili's personality and emphasizes that this situation has improved today.
Georgia has a special close economic and economic ties with Ukraine among the countries of the world. This applies not only to the export-import of goods, but also to tourist traffic, investment, employment, etc. Sh. This relationship was established in 1995 with the conclusion of the Free Trade Agreement [1].
One of the characteristic features of foreign trade between Ukraine and Georgia is the fact that Georgia's share in the total foreign trade of Ukrainian goods is insignificant (about 0.5%), while Ukraine's share in Georgia's total trade turnover reaches 5.1%. According to the results of January-September 2020, among all Georgia's trading partners, Ukraine ranks 7th in terms of trade turnover, 5th in terms of exports of goods and 8th in terms of imports of goods. Georgia-Ukraine turnover in 2020 compared to 2019 has decreased - by 9%, exports - by 13%, imports - by 6% (Table 1). Under these conditions, there is an increase in some goods, in particular, an increase in imports:
	Beef - by 43%;
	Copton – by 17%;
	Milk and cream – by 29%;
	Flat rolled- by 10%.
As for exports from Georgia to Ukraine, the export of ferroalloys (17 times) and the export of scrap (6 times) have increased.
Key words: Ukraine, Georgia; Trade relations; Export-import.
Cosmological Evolution of the Formation Rate of Short Gamma-Ray Bursts with and without Extended Emission
Authors: Dainotti M. G. , Petrosian V. , Bowden L. 
Published: June 2021

Abstract
Originating from neutron star–neutron star or neutron star–black hole mergers, short gamma-ray bursts (SGRBs) are the first electromagnetic emitters associated with gravitational waves (GWs). This association makes the determination of SGRB formation rate (FR) a critical issue. We determine the true SGRB FR and its relation to the cosmic star formation rate (SFR). This can help in determining the expected GW rate involving small mass mergers. We present nonparametric methods for the determination of the evolutions of the luminosity function (LF) and the FR using SGRBs observed by Swift, without any assumptions. These are powerful tools for small samples, such as our sample of 68 SGRBs. We combine SGRBs with and without extended emission (SEE), assuming that both descend from the same progenitor. To overcome the incompleteness introduced by redshift measurements we use the Kolmogorov–Smirnov (KS) test to find flux thresholds yielding a sample of sources with a redshift drawn from the parent sample including all sources. Using two subsamples of SGRBs with flux limits of 4.57 × 10−7 and 2.15 × 10−7 erg cm−2 s−1 with respective KS p = (1, 0.9), we find a 3σ evidence for luminosity evolution (LE), a broken power-law LF with significant steepening at L ∼ 1050 erg s−1, and an FR evolution that decreases monotonically with redshift (independent of LE and the thresholds). Thus, SGRBs may have been more luminous in the past with an FR delayed relative to the SFR as expected in the merger scenario.
Discovery of 13 New Orbital Periods for Classical Novae
Authors: Schaefer Bradley E. 
Published: June 2021

Abstract
I report new orbital periods (P) for 13 classical novae, based on light curves from TESS, AAVSO, and other public archives. These new nova periods now constitute nearly one-seventh of all known nova periods. Five of my systems have P > 1 day, which doubles the number of such systems that must have evolved companion stars. (This is simply because ground-based time series have neither the coverage nor the stability required to discover these small-amplitude long periods.) V1016 Sgr has a rare P below the period gap, and suddenly becomes useful for current debates on evolution of novae. Five of the novae (FM Cir, V399 Del, V407 Lup, YZ Ret, and V549 Vel) have the orbital modulations in the tail of the eruption after the transition phase. Soon after the transition, YZ Ret shows a unique set of aperiodic diminishing oscillations, plus YZ Ret shows two highly significant transient periods, 1.1% and 4.5% longer than the orbital period, much like for the superhump phenomenon. I also report an optical 591.27465 s periodicity for V407 Lup, which is coherent and must be tied to the white dwarf spin period.
The Science Case for Spacecraft Exploration of the Uranian Satellites: Candidate Ocean Worlds in an Ice Giant System
Authors: Cartwright Richard J. , Beddingfield Chloe B. , Nordheim Tom A. , Elder Catherine M. , Castillo-Rogez Julie C. , Neveu Marc , Bramson Ali M. , Sori Michael M. , Buratti Bonnie J. , Pappalardo Robert T. , Roser Joseph E. , Cohen Ian J. , Leonard Erin J. , Ermakov Anton I. , Showalter Mark R. , Grundy William M. , Turtle Elizabeth P. , Hofstadter Mark D. 
Published: June 2021

Abstract
The 27 satellites of Uranus are enigmatic, with dark surfaces coated by material that could be rich in organics. Voyager 2 imaged the southern hemispheres of Uranus’s five largest “classical” moons—Miranda, Ariel, Umbriel, Titania, and Oberon, as well as the largest ring moon, Puck—but their northern hemispheres were largely unobservable at the time of the flyby and were not imaged. Additionally, no spatially resolved data sets exist for the other 21 known moons, and their surface properties are essentially unknown. Because Voyager 2 was not equipped with a near-infrared mapping spectrometer, our knowledge of the Uranian moons’ surface compositions, and the processes that modify them, is limited to disk-integrated data sets collected by ground- and space-based telescopes. Nevertheless, images collected by the Imaging Science System on Voyager 2 and reflectance spectra collected by telescope facilities indicate that the five classical moons are candidate ocean worlds that might currently have, or had, liquid subsurface layers beneath their icy surfaces. To determine whether these moons are ocean worlds, and to investigate Uranus’s ring moons and irregular satellites, close-up observations and measurements made by instruments on board a Uranus orbiter are needed.
International. Stagnation des accords d’entreprise internationaux et recul des accords européens
Authors: Rehfeldt Udo 
Published: June 2021

La dynamique des accords d’entreprise transnationale a atteint son sommet en 2008. Depuis, on observe une stagnation des accords internationaux et un essoufflement des accords européens. L’article analyse les facteurs déterminants de ces dynamiques sur les entreprises françaises et allemandes, en partant des stratégies et pratiques des acteurs. Il révèle le rôle des procédures de mandatement adoptées par les fédérations syndicales européennes et internationales.
Quand l’expérientiel en luxe se construit sur Instagram : synergie ou bataille entre marques et directeurs artistiques ?
Authors: Mercanti-Guérin Maria , de Lassus Christel , Bèzes Christophe 
Published: June 2021

Instagram est devenu le réseau social privilégié des marques de luxe qui y développent leur évènementiel de façon active. Parmi les multiples stratégies de présence sur ce réseau, figure la mise en avant des contenus et des comptes des directeurs artistiques (DA). Or, certains développent des stratégies propres qui rendent floue l’expression des positionnements des marques de luxe pour lesquels ils travaillent. Une méthodologie innovante, par mobilisation de l’intelligence artificielle et par analyse des contenus et objets postés sur Instagram (textes et « captions ») a permis d’étudier l’expérientiel construit sur Instagram par les DA. Les résultats proposent une typologie de la collaboration entre DA et marques. Ils soulignent la difficulté de gérer de multiples émetteurs sur les réseaux sociaux. Les conclusions de cette recherche ouvrent la voie à une réflexion plus globale sur la difficile gestion des influenceurs dans le secteur du luxe.
Signification des packagings et dynamiques d’innovation dans un secteur de luxe traditionnel : l’exemple des champagnes de vignerons
Authors: Ringeval-Deluze Aurélie , Ndione Louis César 
Published: June 2021

À partir d’une analyse sémiotique du packaging de 100 champagnes de vignerons complétée par 19 entretiens d’experts, nous identifions les « codes champagne » traditionnels ainsi que les leviers de l’innovation-packaging et les grandes tensions qu’ils révèlent pour cette catégorie de produits. Nous complétons ainsi la littérature marketing portant sur le packaging des vins de prestige.
Image de la pensée et pensée sans image chez Deleuze & Guattari
Authors: Bénit Bernard 
Published: June 2021

« Comme toute grande philosophie, celle de Deleuze avant Guattari et avec Guattari renouvelle la définition de la pensée. Depuis Différence et répétition , la pensée n’est pour Deleuze ni naturelle ni spontanée, elle est le produit d’une genèse : Deleuze part d’une critique de l’image représentative de la pensée qui lui permet de dégager le vrai commencement de la pensée, ses conditions réelles. Avec cette genèse, grâce à laquelle la pensée se cherche un sol autre que la représentation en renonçant en même temps à tout fondement, Deleuze résout, pour son propre compte, le problème du commencement en philosophie, en faisant surgir une pensée sans image. Par la suite, Deleuze et Guattari construisent ensemble une nouvelle métaphysique qui semble se passer, en apparence seulement, des notions d’image de la pensée et de pensée sans image. En réalité, à l’unique « Image de la pensée » qu’il s’agissait de détruire dans Différence et répétition , Deleuze et Guattari substituent, dès Mille plateaux, une pluralité d’images de la pensée, chacune étant historiquement et singulièrement déterminée. Ils esquissent même dans cet ouvrage l’idée d’une « noologie » qu’ils prendraient pour objet d’étude. Ces images deviendront les plans d’immanence de Qu’est-ce que la philosophie ? . Quant à la pensée sans image, nous montrerons que, loin de disparaître, elle prend différentes formes, notamment celle du chaos, dans leur dernier ouvrage. Notre hypothèse est donc que, sous des vocables changeants, ces deux idées, comme leur relation mise à jour par Deleuze, ne disparaissent pas de leur métaphysique commune. »