bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interventional Optical Imaging Permits Instant Visualization of Pathological Zones of Ablated Tumor Periphery and Residual Tumor Detection
Authors: Kan Xuefeng , Zhou Guanhui , Zhang Feng , Ji Hongxiu , Zheng Hui , Chick Jeffrey Forris Beecham , Valji Karim , Zheng Chuansheng , Yang Xiaoming 
Published: July 2021

AbstractOptical imaging (OI) provides real-time clinical imaging capability and simultaneous molecular, morphological, and functional information of disease processes. In this study, we present a new interventional OI technique, which enables in vivo visualization of three distinct pathologic zones of ablated tumor periphery for immediate detection of residual tumors during a radiofrequency ablation (RFA) session. Rabbits with orthotopic hepatic tumors were divided into two groups (n = 8/group): incomplete RFA and complete RFA. Indocyanine green-based interventional OI was used to differentiate three pathological zones: ablated tumor, transition margin, and residual tumor or surrounding normal liver—with quantitative comparison of signal-to-background ratios among the three zones and between incompletely and completely ablated tumors. Subsequent ex vivo OI and pathologic correlation were performed to confirm the findings of interventional OI. Interventional OI could differentiate incompletely or completely ablated tumor peripheries, thus permitting identification of residual tumor. This technique may open new avenues for immediate assessment of tumor eradication during a single interventional ablation session.Significance:Interventional optical imaging can instantly visualize pathologic zones of ablated tumor peripheries to detect residual tumors, which could revolutionize current image-guided interventional oncologic ablation techniques.
Economic Evaluation of Web- versus Telephone-based Interventions to Simultaneously Increase Colorectal and Breast Cancer Screening Among Women
Authors: Huang Danmeng , Lairson David R. , Chung Tong H. , Monahan Patrick O. , Rawl Susan M. , Champion Victoria L. 
Published: July 2021

Abstract

Screening for colorectal and breast cancer is considered cost effective, but limited evidence exists on cost-effectiveness of screening promotion interventions that simultaneously target both cancers. Increasing Colorectal and Breast Cancer Screening (Project COBRA), a randomized controlled trial conducted in the community, examined the cost-effectiveness of an innovative tailored web-based intervention compared with tailored telephone counseling and usual care. Screening status at 6 months was obtained by participant surveys plus medical record reviews. Cost was prospectively measured from the patient and provider perspectives using time logs and project invoices. Relative efficiency of the interventions was quantified by the incremental cost-effectiveness ratios. Nonparametric bootstrapping and net benefit regression analysis were used to assess statistical uncertainty of the results. The average cost per participant to implement the Phone counseling, Web-based, and Web + Phone counseling interventions were $277, $314, and $337, respectively. Comparing Phone counseling with usual care resulted in an additional cost of $300 (95% confidence interval [CI]: $283–$320) per cancer screening test and $421 (95% CI: $400–$441) per additional person screened in the target population. Phone counseling alone was more cost-effective than the Web + Phone intervention. Web-based intervention alone was more costly but less effective than the Phone counseling. When simultaneously promoting screening for both colorectal and breast cancer the Web-based intervention was less cost-effective compared with Phone and Web + Phone strategies. The results suggest that targeting multiple cancer screening may improve the cost-effectiveness of cancer screening interventions.

Prevention Relevance:
This study informs researchers, decision makers, healthcare providers, and payers about the improved cost-effectiveness of targeting multiple cancer screenings for cancer early detection programs.
Common Analgesic Use for Menstrual Pain and Ovarian Cancer Risk
Authors: Sasamoto Naoko , Babic Ana , Vitonis Allison F. , Titus Linda , Cramer Daniel W. , Trabert Britton , Tworoger Shelley S. , Terry Kathryn L. 
Published: July 2021

Abstract

Menstrual pain has been associated with increased ovarian cancer risk, presumably through increased inflammation, which is known to play a critical role in ovarian carcinogenesis. Analgesic medications are frequently used to treat menstrual pain, some of which lower ovarian cancer risk. In this study, we examined the association between analgesic use for menstrual pain during the premenopausal period and ovarian cancer risk among women with history of menstrual pain. We used data from the New England Case-Control Study, including 1,187 epithelial ovarian cancer cases and 1,225 population-based controls enrolled between 1998 and 2008 with detailed information on analgesic use for their menstrual pain. We used unconditional logistic regression to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for the association between analgesic use (i.e., aspirin, ibuprofen, acetaminophen) for menstrual pain and ovarian cancer risk. We further conducted a stratified analysis by intensity of menstrual pain (mild/moderate, severe). Among women with menstrual pain during their 20s and 30s, ever use of analgesics for menstrual pain was not significantly associated with ovarian cancer risk. However, among women with severe menstrual pain, ever use of aspirin or acetaminophen for menstrual pain was inversely associated with risk (OR, 0.41; 95% CI, 0.18–0.94 and OR, 0.43; 95% CI, 0.21–0.88 compared with never users, respectively). No significant association was observed between analgesic use and ovarian cancer risk among women with mild/moderate menstrual pain (Pinteraction ≤ 0.03). Our results suggest that use of aspirin or acetaminophen for severe menstrual pain may be associated with lower risk of ovarian cancer.

Prevention Relevance:
This study investigates whether analgesic use specifically for menstrual pain during the premenopausal period influences ovarian cancer risk. Our results suggest use of aspirin or acetaminophen for severe menstrual pain may be associated with lower risk of ovarian cancer among women with severe menstrual pain.
Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-cell Expansion, Trafficking, and Toxicity
Authors: Sakemura Reona , Bansal Aditya , Siegler Elizabeth L. , Hefazi Mehrdad , Yang Nan , Khadka Roman H. , Newsom Alysha N. , Hansen Michael J. , Cox Michelle J. , Manriquez Roman Claudia , Schick Kendall J. , Can Ismail , Tapper Erin E. , Nevala Wendy K. , Adada Mohamad M. , Bezerra Evandro D. , Kankeu Fonkoua Lionel Aurelien , Horvei Paulina , Ruff Michael W. , Parikh Sameer A. , Pandey Mukesh K. , DeGrado Timothy R. , Suksanpaisan Lukkana , Kay Neil E. , Peng Kah-Whye , Russell Stephen J. , Kenderian Saad S. 
Published: July 2021

Abstract

Although chimeric antigen receptor T (CART)–cell therapy has been successful in treating certain hematologic malignancies, wider adoption of CART-cell therapy is limited because of minimal activity in solid tumors and development of life-threatening toxicities, including cytokine release syndrome (CRS). There is a lack of a robust, clinically relevant imaging platform to monitor in vivo expansion and trafficking to tumor sites. To address this, we utilized the sodium iodide symporter (NIS) as a platform to image and track CART cells. We engineered CD19-directed and B-cell maturation antigen (BCMA)–directed CART cells to express NIS (NIS+CART19 and NIS+BCMA-CART, respectively) and tested the sensitivity of 18F-TFB-PET to detect trafficking and expansion in systemic and localized tumor models and in a CART-cell toxicity model. NIS+CART19 and NIS+BCMA-CART cells were generated through dual transduction with two vectors and demonstrated exclusive 125I uptake in vitro. 18F-TFB-PET detected NIS+CART cells in vivo to a sensitivity level of 40,000 cells. 18F-TFB-PET confirmed NIS+BCMA-CART-cell trafficking to the tumor sites in localized and systemic tumor models. In a xenograft model for CART-cell toxicity, 18F-TFB-PET revealed significant systemic uptake, correlating with CART-cell in vivo expansion, cytokine production, and development of CRS-associated clinical symptoms. NIS provides a sensitive, clinically applicable platform for CART-cell imaging with PET scan. 18F-TFB-PET detected CART-cell trafficking to tumor sites and in vivo expansion, correlating with the development of clinical and laboratory markers of CRS. These studies demonstrate a noninvasive, clinically relevant method to assess CART-cell functions in vivo.
Spouse’s Cardiovascular Disease As a Risk Factor for Cardiovascular Disease in Middle-Aged Adults: A Matched-Pair Cohort Study
Authors: Ohbe Hiroyuki , Yasunaga Hideo 
Published: July 2021

Background:
Little is known about the risk of subsequent cardiovascular events in individuals whose spouse has a history of cardiovascular diseases. We assessed whether the spouse’s history of cardiovascular disease is associated with a greater risk of cardiovascular events.

Methods:
Using data on married couples from the Japan Medical Data Center database (April 2008–August 2018), we conducted a matched-pair cohort study by matching individuals who had no history of cardiovascular disease and whose spouse had a history of cardiovascular disease at their first health check-up (exposure group) with up to 4 individuals who had no history of cardiovascular disease and whose spouse had no history of cardiovascular disease at their first health check-up (nonexposure group) matched for birth year, sex, and first health check-up year. We compared severe cardiovascular events after the first health check-up between the 2 groups.

Results:
Among 236 527 eligible married couples (473 054 spouses), we identified 13 759 individuals in the exposure group who were matched with 55 027 individuals in the nonexposure group. During the mean 95-month observational period from the first health check-up, the percentage of individuals with severe cardiovascular events was higher in the exposure group than in the nonexposure group (0.6% [82/13 759] versus 0.4% [224/55 027], respectively), with a hazard ratio of 1.48 (95% CI, 1.15–1.90). Analyses stratified by sex showed that the hazard ratios of the exposure to the spouse’s history of cardiovascular disease for severe cardiovascular events in women and men were 1.22 (95% CI, 0.82–1.83) and 1.68 (95% CI, 1.22–2.32), respectively.

Conclusions:
This study suggests that a spouse’s history of cardiovascular disease can be a risk factor for subsequent cardiovascular events in men but not in women. Further studies are needed to confirm our findings and to explore effective primary prevention strategies for these individuals.
Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19
Authors: Koenis Duco Steven , Beegun Issa , Jouvene Charlotte Camille , Aguirre Gabriel Amador , Souza Patricia Regina , Gonzalez-Nunez Maria , Ly Lucy , Pistorius Kimberly , Kocher Hemant M. , Ricketts William , Thomas Gavin , Perretti Mauro , Alusi Ghassan , Pfeffer Paul , Dalli Jesmond 
Published: July 2021

Rationale:
Resolution mechanisms are central in both the maintenance of homeostasis and the return to catabasis following tissue injury and infections. Among the proresolving mediators, the essential fatty acid-derived specialized proresolving lipid mediators (SPM) govern immune responses to limit disease severity. Notably, little is known about the relationship between the expression and activity of SPM pathways, circulating phagocyte function and disease severity in patients infected with the novel severe acute respiratory syndrome coronavirus 2 leading to coronavirus disease 2019 (COVID-19).

Objective:
Herein, we investigated the link between circulating SPM concentrations and phagocyte activation status and function in patients with COVID-19 (n=39) compared with healthy (n=12) and post-COVID-19 (n=8) volunteers.

Methods and Results:
Lipid mediator profiling demonstrated that plasma SPM concentrations were upregulated in patients with mild COVID-19 and are downregulated in those with severe disease. SPM concentrations were correlated with both circulating phagocyte activation status and function. Perturbations in plasma SPM concentrations and phagocyte activation were retained after the resolution of COVID-19 clinical symptoms. Treatment of patients with dexamethasone upregulated both the expression of SPM biosynthetic enzymes in circulating phagocytes and plasma concentration of these mediators. Notably, incubation of phagocytes from patients with COVID-19 with SPM rectified their phenotype and function. This included a downregulation in the expression of activation markers, a decrease in the tissue factor and inflammatory cytokine expression, and an upregulation of bacterial phagocytosis.

Conclusions:
The present findings suggest that downregulation of systemic SPM concentrations is linked with both increased disease severity and dysregulated phagocyte function. They also identify the upregulation of these mediators by dexamethasone as a potential host protective mechanism elicited by this drug in patients with COVID-19. Taken together, our findings elucidate a role for altered resolution mechanisms in the disruption of phagocyte responses and the propagation of systemic inflammation in COVID-19.
Regional Adiposity and Risk of Heart Failure and Mortality: The Jackson Heart Study
Authors: Rao Vishal N. , Bush Christopher G. , Mongraw‐Chaffin Morgana , Hall Michael E. , Clark Donald , Fudim Marat , Correa Adolfo , Hammill Bradley G. , O’Brien Emily , Min Yuan‐I , Mentz Robert J. 
Published: July 2021

Background
Visceral adipose tissue (VAT) is associated with incident heart failure (HF) and HF with preserved ejection fraction, yet it is unknown how pericardial and abdominal adiposity affect HF and mortality risks in Black individuals. We examined the associations of pericardial adipose tissue (PAT), VAT, and subcutaneous adipose tissue (SAT) with incident HF hospitalization and all‐cause mortality in a large community cohort of Black participants.

Methods and Results

Among the 2882 Jackson Heart Study Exam 2 participants without prevalent HF who underwent body computed tomography, we used Cox proportional hazards models to examine associations between computed tomography–derived regional adiposity and incident HF hospitalization and all‐cause mortality. Fully adjusted models included demographics and cardiovascular disease risk factors. Median follow‐up was 10.6 years among participants with available VAT (n=2844), SAT (n=2843), and PAT (n=1386). Fully adjusted hazard ratios (95% CIs) of distinct computed tomography–derived adiposity measures (PAT per 10 cm
3
, VAT or SAT per 100 cm
3
) were as follows: for incident HF, PAT 1.08 (95% CI, 1.02–1.14) and VAT 1.04 (95% CI, 1.01–1.08); for HF with preserved ejection fraction, PAT 1.13 (95% CI, 1.04–1.21) and VAT 1.07 (95% CI, 1.01–1.13); for mortality, PAT 1.07 (95% CI, 1.03–1.12) and VAT 1.01 (95% CI, 0.98–1.04). SAT was not associated with either outcome.

Conclusions
High PAT and VAT, but not SAT, were associated with incident HF and HF with preserved ejection fraction, and only PAT was associated with mortality in the fully adjusted models in a longitudinal community cohort of Black participants. Future studies may help understand whether changes in regional adiposity improves HF, particularly HF with preserved ejection fraction, risk predictions.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT00005485.
Collaborative Relationship-Focused Occupational Therapy: Evolving Lexicon and Practice
Authors: Restall Gayle J. , Egan Mary Y. 
Published: July 2021

Background. Client-centred practice has been part of occupational therapists’ identity for several decades. However, therapists have begun to question whether the term obstructs critical relational aspects of therapy. Purpose. The purpose of this article is to summarize critiques of the use of the term client-centred and propose an expanded descriptor and a fundamental shift in how occupational therapists engage with individuals, families, groups, communities, and populations. Key Issues. Three themes summarize critiques of how client-centred practice has been envisioned: (a) the language of client-centred, (b) insufficient appreciation of how the therapist affects the relationship, and (c) inadequate consideration of the relational context of occupation. We propose collaborative relationship-focused practice that has key relational elements of being contextually relevant, nuanced, and safe, and promotes rights-based self-determination. Conclusion. We argue that these essential relational elements, along with a focus on occupations, are required to promote occupational participation, equity, and justice.
Relationship Between Family Functioning, Parents’ Psychosocial Factors, and Children’s Well-Being
Authors: Gaspar Tania , Gomez-Baya Diego , Trindade Joana S. , Botelho Guedes Fábio , Cerqueira Ana , de Matos Margarida G. 
Published: July 2021

The main objective of this study is to explore the impact of the psychosocial factors (social support, resilience, and mental health) on the family functioning and on the parent’s perception of their children’s well-being. Participants were 1757 parents of children aged 6 to 16 years, 77.3% female ( N = 1359), and 22.7% male ( N = 398), aged between 20 and 80 years ( M = 41.61 and SD = 5.71). A path analyses model indicated that social support and resilience, which were positively associated, presented positive effects on parental mental health and on family functioning. No effect was observed on family functioning by parental mental health after including the effects by social support and resilience. Finally, this model pointed out that better family functioning, more social support, and more resilience skills were related to better child well-being. Implications to research and to prevention and psychological intervention in relation to parental skills and family functioning are presented in order to promote children well-being and healthy development.
Effects of a progressive resistance exercise program in patients with hand osteoarthritis: A randomized, controlled trial with a blinded assessor
Authors: Nery Michele , Natour Jamil , Jennings Fabio , Fernandes Artur da Rocha Corrêa , Souza Marcelo C , Jones Anamaria 
Published: July 2021

Objective: To assess the effectiveness of a progressive resistance strength program on pain, function and strength in hand osteoarthritis patients. Design: Randomized controlled trial. Settings: Outpatients, University Hospital. Subjects: Sixty hand osteoarthritis patients were randomly allocated to exercise group ( n = 30) or control group ( n = 30). Intervention: The exercise group performed a progressive resistance strength program for hand muscles over 12 weeks. Both groups had a single education session. Main measures: The primary outcome was pain intensity (numeric pain scale). The secondary outcomes were – AUSCAN Hand Osteoarthritis Index, Cochin Hand Functional Scale for function and grip and pinch strength. A blinded evaluator performed the evaluations at baseline, 6 and 12 weeks. Results: The mean age were 68.9 (8.8) and 64.7 (8.9) for control and exercise groups, respectively. No significant differences between-group was observed for pain after 12 weeks (mean difference between groups was −1.30 (−0.02 to 2.62) for dominant hand and −1.33 (0.01–2.65) for non-dominant hand at T12, with P = 0.085 and 0.295, respectively). Regarding secondary outcomes, statistically significant differences between groups were found in exercise group: AUSCAN index – total score ( P = 0.005), pain ( P = 0.006), function ( P = 0.047), and Cochin scale ( P = 0.042) with the following mean difference between groups: −9.9 (4.07–15.73), −3.26 (1.06–5.46), −5.03 (1.20–8.86), and −6.27 (0.18–12.36), respectively. Conclusion: No difference was observed for pain (numerical pain scale) after the progressive resistance exercise program performed, however in exercise group, an improvement was observed on secondary outcomes such as pain during activities and function for patients with hand osteoarthritis. Level of evidence: 1b
Do anti-platelet drugs improve duration of continuous renal replacement therapy? A retrospective cohort study in cardiac ICU patients
Authors: Gupta Vivek , Aslam Naved , Chhabra Shibba Takkar , Makkar Vikas , Mohan Bishav , Kapoor Samir , Singh Vikram Pal , Kumar Rajiv , Grover Suvir , Kaur Gurkirat , Sethi Suman , Kaur Simran , Goyal Abhishek , Singh Bhupinder , Singh Gurbhej , Ralhan Sarju , Wander Gurpreet Singh 
Published: July 2021

Objective: The objective of this study was to investigate the impact of anti-platelet drug/s on duration of continuous renal replacement therapy (CRRT) in those patients where anti-coagulants were not used due to certain contraindications and in cases where patients were on anti-platelet drugs and were given anti-coagulant during CRRT. Method: This single-center, retrospective cohort study was conducted using the medical records patients treated with CRRT in the cardiac ICU of the inpatient urban facility, located in North India. Data was collected from only those patients who received CRRT for the duration of at least 12 h. Patient’s in NAC group were not on any anti-platelet/s and did not receive anti-coagulant during CRRT. AC and AP group patients received anti-coagulant alone or were already on anti-platelet/s and did not receive anti-coagulant respectively while ACAP group patients were on anti-platelet drug/s and also received anti-coagulant during CRRT. Result: Patients in AC, AP, or ACAP group showed significantly ( p < 0.001) higher CRRT filter life compared to NAC group. The median CRRT filter life was significantly higher in the ACAP group compared to AC ( p < 0.05) and AP ( p < 0.001) groups. Conclusion: This study indicates that systemic anti-platelet therapy can provide additional support in critical patients undergoing CRRT even with or without anti-coagulant therapy. However, the increase in CRRT filter life was more profound in patients who were on anti-platelet/s and also received anti-coagulant drug/s during CRRT.