bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERANCANGAN ENTERPRISE ARCHITECTURE LAYANAN SPBE (E-GOVERNMENT) DI LINGKUNGAN PEMKAB SUKABUMI
Authors: Wulandari Devita , Gumilang Soni Fajar Surya , Mulyana Rahmat 
Published: December 2021

Abstract: To increase the Electronic-Based Government System (SPBE) maturity level and comply with Presidential Regulation no. 95 of 2018, the Sukabumi Regency Government needs to standardize the SPBE design to be implemented appropriately integrated with utilizing technological advances optimally. One of the frameworks used to design the SPBE architecture is using the Enterprise Architecture (EA). EA aims to meet the gap between the needs of stakeholders and the availability of government administration services. The journal's focus on the design of this SPBE EA is on the SPBE Service Domain in the Electronic-Based Government Administration Service. The design is carried out using a combination of references to the SPBE Presidential Regulation and the National SPBE Master Plan Attachment and one of the main components of the EA framework, namely TOGAF ADM. This design produces an output in the form of an Electronic-Based Government Administration Service Catalog. It is expected to be used as a reference in developing technology in the Regency Government Sukabumi both from practical contributions and academic contributions. Keywords: Enterprise Architecture; Service Architecture; SPBE; TOGAF ADM Abstrak: Dalam rangka meningkatkan tingkat kematangan Sistem Pemerintah Berbasis Elektronik (SPBE) dan mematuhi Peraturan Presiden No. 95 Tahun 2018, Pemerintah Kabupaten Sukabumi perlu melakukan standarisasi terhadap perancangan SPBE agar dapat terimplementasi dan terintegrasi dengan baik dalam memanfaatkan kemajuan teknologi secara optimal. Salah satu kerangka kerja yang bisa digunakan untuk merancang Arsitektur SPBE yaitu menggunakan Enterprise Architecture (EA). EA bertujuan untuk memenuhi kesenjangan antara kebutuhan pemangku kepentingan dengan ketersediaan layanan administrasi pemerintahan. Fokus jurnal pada perancangan EA SPBE ini yaitu pada Domain Layanan SPBE di bagian Layanan Administrasi Pemerintahan Berbasis Elektronik. Perancangan yang dilakukan memanfaatkan kombinasi antara referensi pada Perpres SPBE dan Lampiran Rencana Induk SPBE Nasional serta salah satu komponen utama framework EA yaitu TOGAF ADM. Perancangan ini menghasilkan keluaran berupa Katalog Layanan Administrasi Pemerintahan Berbasis Elektronik dan diharapkan dapat dijadikan sebagai acuan dalam melakukan pengembangan teknologi di Pemkab. Sukabumi baik dari kontribusi praktis maupun kontribusi akademik. Kata kunci: Arsitektur Layanan; Enterprise Architecture; SPBE; TOGAF ADM
Can a Glove-Coach Technology Significantly Increase the Efficacy of Cardiopulmonary Resuscitation on Non-healthcare Professionals? A Controlled Trial
Authors: Musiari Michele , Saporito Andrea , Ceruti Samuele , Biggiogero Maira , Iattoni Martina , Glotta Andrea , Cantini Laura , Capdevila Xavier , Cassina Tiziano 
Published: December 2021

Introduction: Cardiovascular accidents are the world's leading cause of death. A good quality cardiopulmonary resuscitation (CPR) can reduce cardiac arrest-associated mortality. This study aims to test the coaching system of a wearable glove, providing instructions during out-of-hospital CPR.Materials and Methods: We performed a single-blind, controlled trial to test non-healthcare professionals during a simulated CPR performed on an electronic mannequin. The no-glove group was the control. The primary outcome was to compare the accuracy of depth and frequency of two simulated CPR sessions. Secondary outcomes were to compare the decay of CPR performance and the percentage of the duration of accurate CPR.Results: About 130 volunteers were allocated to 1:1 ratio in both groups; mean age was 36 ± 15 years (min–max 21–64) and 62 (48%) were men; 600 chest compressions were performed, and 571 chest compressions were analyzed. The mean frequency in the glove group was 117.67 vs. 103.02 rpm in the control group (p &lt; 0.001). The appropriate rate cycle was 92.4% in the glove group vs. 71% in the control group, with a difference of 21.4% (p &lt; 0.001). Mean compression depth in the glove group was 52.11 vs. 55.17 mm in the control group (p &lt; 0.001). A mean reduction of compression depth over time of 5.3 mm/min was observed in the control group vs. 0.83 mm/min of reduction in the glove group.Conclusion: Visual and acoustic feedbacks provided through the utilization of the glove's coaching system were useful for non-healthcare professionals' CPR performance.
Recombinant Human Follicle-Stimulating Hormone Alfa Dose Adjustment in US Clinical Practice: An Observational, Retrospective Analysis of a Real-World Electronic Medical Records Database
Authors: Mahony Mary C. , Hayward Brooke , Mottla Gilbert L. , Richter Kevin S. , Beall Stephanie , Ball G. David , D’Hooghe Thomas 
Published: December 2021

PurposeTo determine the pattern of dose adjustment of recombinant human follicle-stimulating hormone alfa (r-hFSH-alfa) during ovarian stimulation (OS) for assisted reproductive technology (ART) in a real-world setting.MethodsThis was an observational, retrospective analysis of data from an electronic de-identified medical records database including 39 clinics in the USA. Women undergoing OS for ART (initiated 2009–2016) with r-hFSH-alfa (Gonal-f® or Gonal-f RFF Redi-ject®) were included. Assessed outcomes were patients’ baseline characteristics and dosing characteristics/cycle.ResultsOf 33,962 ART cycles, 13,823 (40.7%) underwent dose adjustments: 23.4% with ≥1 dose increase, 25.4% with ≥1 dose decrease, and 8.1% with ≥1 increase and ≥1 decrease. Patients who received dose adjustments were younger (mean [SD] age 34.8 [4.58] years versus 35.9 [4.60] years, p&lt;0.0001) and had lower BMI (25.1 [5.45] kg/m2 versus 25.5 [5.45] kg/m2, p&lt;0.0001) than those who received a constant dose. The proportion of patients with non-normal ovarian reserve was 38.4% for those receiving dose adjustment versus 51.9% for those with a constant dose. The mean (SD) number of dose changes/cycle was 1.61 (0.92) for cycles with any dose adjustment, 1.72 (1.03) for cycles with ≥1 dose increase, 2.77 (1.00) for cycles with ≥1 dose increase and ≥1 decrease (n=2,755), and 1.88 (1.03) for cycles with ≥1 dose decrease.ConclusionsDose adjustment during OS is common in clinical practice in the USA and occurred more often in younger versus older patients, those with a high versus non-normal ovarian reserve or those with ovulation disorders/polycystic ovary syndrome versus other primary diagnoses of infertility.
Mild Anemia May Affect Thyroid Function in Pregnant Chinese Women During the First Trimester
Authors: Nie Guan-ying , Wang Rui , Liu Peng , Li Ming , Sun Dian-jun 
Published: December 2021

BackgroundPregnant women are often susceptible to anemia, which can damage the thyroid gland. However, compared with moderate and severe anemia, less attention has been paid to mild anemia. The purpose of this study was to evaluate the effect of mild anemia on the thyroid function in pregnant women during the first trimester.MethodsA total of 1,761 women in the first trimester of their pregnancy were enrolled from Shenyang, China, and divided into mild anemia and normal control groups based on their hemoglobin levels. Thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) levels were compared between the two groups.ResultsThe TSH levels of pregnant women with mild anemia were higher than those of pregnant women without mild anemia (p &lt; 0.05). Normal control women were selected to set new reference intervals for TSH, FT3, and FT4 levels during the first trimester, which were 0.11–4.13 mIU/l, 3.45–5.47 pmol/l, and 7.96–16.54 pmol/l, respectively. The upper limit of TSH 4.13 mU/l is close to the upper limit 4.0 mU/l recommended in the 2017 American Thyroid Association (ATA) guidelines, indicating that exclusion of mild anemia may reduce the difference in reference values from different regions. Mild anemia was related to 4.40 times odds of abnormally TSH levels (95% CI: 2.84, 6.76) and 5.87 increased odds of abnormal FT3 (95% CI: 3.89, 8.85). The proportion of hypothyroidism and subclinical hypothyroidism in patients with mild anemia was higher than that in those without anemia (0.6% vs. 0, p = 0.009; 12.1% vs. 1.9%, p &lt; 0.001). Mild anemia was related to 7.61 times increased odds of subclinical hypothyroidism (95% CI: 4.53, 12.90).ConclusionsMild anemia may affect thyroid function during the first trimester, which highlights the importance of excluding mild anemia confounding when establishing a locally derived specific reference interval for early pregnancy.
NDRG1 Activity in Fat Depots Is Associated With Type 2 Diabetes and Impaired Incretin Profile in Patients With Morbid Obesity
Authors: Stafeev Iurii , Sklyanik Igor , Mamontova Elizaveta , Michurina Svetlana , Shestakova Ekaterina , Yah’yaev Kamil , Yurasov Anatoliy , Masnikov Denis , Sineokaya Maria , Ratner Elizaveta , Vorotnikov Alexander , Menshikov Mikhail , Parfyonova Yelena , Shestakova Marina 
Published: December 2021

ObjectiveWe aimed to investigate insulin-, mTOR- and SGK1-dependent signaling basal states in morbidly obese patients’ fat. We analyzed the correlation between the signaling activity, carbohydrate metabolism, and incretin profiles of patients.MethodsThe omental and subcutaneous fat was obtained in patients with obesity. The omental study included 16 patients with normal glucose tolerance (NGT) and 17 patients with type 2 diabetes mellitus (T2DM); the subcutaneous study included 9 NGT patients and 12 T2DM patients. Insulin resistance was evaluated using the hyperinsulinemic euglycemic clamp test and HOMA-IR index. The oral glucose tolerance test (OGTT) for NGT patients and mixed meal tolerance test (MMTT) for T2DM patients were performed. The levels of incretins (GLP-1, GIP, oxyntomodulin) and glucagon were measured during the tests. Signaling was analyzed by Western blotting in adipose tissue biopsies.ResultsWe have shown equal levels of basal phosphorylation of insulin- and mTOR-dependent signaling in omental fat depot in NGT and T2DM obese patients. Nevertheless, pNDRG1-T346 was decreased in omental fat of T2DM patients. Correlation analysis has shown an inverse correlation of pNDRG1-T346 in omental fat and diabetic phenotype (HbA1c, impaired incretin profile (AUC GLP-1, glucagon)). Moreover, pNDRG1-T346 in subcutaneous fat correlated with impaired incretin levels among obese patients (inverse correlation with AUC glucagon and AUC GIP).ConclusionsAccording to results of the present study, we hypothesize that phosphorylation of pNDRG1-T346 can be related to impairment in incretin hormone processing. pNDRG1-T346 in adipose tissue may serve as a marker of diabetes-associated impairments of the systemic incretin profile and insulin sensitivity.
Association Between the Triglyceride–Glucose Index and the Incidence of Diabetes in People With Different Phenotypes of Obesity: A Retrospective Study
Authors: Zou Su , Yang Chenxi , Shen Rui , Wei Xiang , Gong Junwen , Pan Yali , Lv Yang , Xu Yingjia 
Published: December 2021

AimWe aimed to examine the relationship between the Triglyceride–glucose (TyG) index and the incidence of type 2 diabetes in people with different phenotypes of obesity.MethodsFrom May 1, 1994 to December 31, 2016, 15,464 participants were enrolled in the medical examination program at the Murakami Memorial Hospital to determine the relationship between the TyG index and the incidence of type 2 diabetes in people with different phenotypes of obesity after 5.38 years of follow-up.ResultsBesides triglycerides, HbA1c%, and FPG, the incidence of type 2 diabetes was found to be significantly associated with the TyG index (p &lt;0.001), age (p &lt;0.001), BMI (p = 0.033), current smoker (p &lt;0.001), and fatty liver (p &lt;0.001). In participants with visceral fat obesity and/or ectopic fat obesity and normal BMI, the TyG index was significantly associated with the incidence of type 2 diabetes after adjusting for confounding factors. In patients with BMI ≥25 mg/m2, although there was a trend of the relationship between the TyG index and the incidence of type 2 diabetes, the relationship was no longer positive.ConclusionIn participants with obesity involving visceral fat obesity and/or fatty liver and normal BMI which is not a measure of body fat distribution, there was a significant association between the TyG index and incidence of T2DM.
Modelling Particulate Matter Using Multivariate and Multistep Recurrent Neural Networks
Authors: Saini Tushar , Chaturvedi Pratik , Dutt Varun 
Published: December 2021

Air quality is a major problem in the world, having severe health implications. Long-term exposure to poor air quality causes pulmonary and cardiovascular diseases. Several studies have also found that deteriorating air quality also causes substantial economic losses. Thus, techniques that can forecast air quality with higher accuracy may help reduce health and economic consequences. Prior research has utilized state-of-the-art artificial neural network and recurrent neural network models for forecasting air quality. However, a comprehensive investigation of different architectures of recurrent neural network, especially LSTMs and ensemble techniques, has been less explored. Also, there have been less explorations of long-term air quality forecasts via these methods exists. This research proposes the development and calibration of recurrent neural network models and their ensemble, which can forecast air quality in terms of PM2.5 concentration 6 hours ahead in time. For forecasting air quality, a vanilla-LSTM, a stack-LSTM, a bidirectional-LSTM, a CNN-LSTM, and an ensemble of individual LSTM models were trained on the UCI Machine Learning Beijing dataset. Data were split into two parts, where 80% of data were used for training the models, while the remaining 20% were used for validating the models. For comparative analysis, four regression losses were calculated, namely root mean squared error, mean absolute percentage error, mean absolute error and Pearson’s correlation coefficient. Results revealed that among all models, the ensemble model performed the best in predicting the PM2.5 concentrations. Furthermore, the ensemble model outperformed other models reported in literature by a long margin. Among the individual models, the bidirectional-LSTM performed the best. We highlight the implications of this research on long-term forecasting of air quality via recurrent and ensemble techniques.
Identification of an Autophagy-Related Pair Signature for Predicting Prognoses and Immune Activity in Pancreatic Adenocarcinoma
Authors: Zhang Qian , Lv Liping , Ma Ping , Zhang Yangyang , Deng Jiang , Zhang Yanyu 
Published: December 2021

BackgroundPancreatic adenocarcinoma (PAAD) spreads quickly and has a poor prognosis. Autophagy research on PAAD could reveal new biomarkers and targets for diagnosis and treatment.MethodsAutophagy-related genes were translated into autophagy-related gene pairs, and univariate Cox regression was performed to obtain overall survival (OS)-related IRGPs (P&lt;0.001). LASSO Cox regression analyses were performed to construct an autophagy-related gene pair (ARGP) model for predicting OS. The Cancer Genome Atlas (TCGA)-PAAD cohort was set as the training group for model construction. The model predictive value was validated in multiple external datasets. Receiver operating characteristic (ROC) curves were used to evaluate model performance. Tumor microenvironments and immune infiltration were compared between low- and high-risk groups with ESTIMATE and CIBERSORT. Differentially expressed genes (DEGs) between the groups were further analyzed by Gene Ontology biological process (GO-BP) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses and used to identify potential small-molecule compounds in L1000FWD.ResultsRisk scores were calculated as follows: ATG4B|CHMP4C×(-0.31) + CHMP2B|MAP1LC3B×(0.30) + CHMP6|RIPK2 ×(-0.33) + LRSAM1|TRIM5×(-0.26) + MAP1LC3A|PAFAH1B2×(-0.15) + MAP1LC3A|TRIM21×(-0.08) + MET|MFN2×(0.38) + MET|MTDH×(0.47) + RASIP1|TRIM5×(-0.23) + RB1CC1|TPCN1×(0.22). OS was significantly shorter in the high-risk group than the low-risk group in each PAAD cohort. The ESTIMATE analysis showed no difference in stromal scores but a significant difference in immune scores (p=0.0045) and ESTIMATE scores (p=0.014) between the groups. CIBERSORT analysis showed higher naive B cell, Treg cell, CD8 T cell, and plasma cell levels in the low-risk group and higher M1 and M2 macrophage levels in the high-risk group. In addition, the results showed that naive B cells (r=-0.32, p&lt;0.001), Treg cells (r=-0.31, p&lt;0.001), CD8 T cells (r=-0.24, p=0.0092), and plasma cells (r=-0.2, p&lt;0.026) were statistically correlated with the ARGP risk score. The top 3 enriched GO-BPs were signal release, regulation of transsynaptic signaling, and modulation of chemical synaptic transmission, and the top 3 enriched KEGG pathways were the insulin secretion, dopaminergic synapse, and NF-kappa B signaling pathways. Several potential small-molecule compounds targeting ARGs were also identified.ConclusionOur results demonstrate that the ARGP-based model may be a promising prognostic indicator for identifying drug targets in patients with PAAD.
Effect of Different Disease-Modifying Therapies on Humoral Response to BNT162b2 Vaccine in Sardinian Multiple Sclerosis Patients
Authors: Pitzalis Maristella , Idda Maria Laura , Lodde Valeria , Loizedda Annalisa , Lobina Monia , Zoledziewska Magdalena , Virdis Francesca , Delogu Giuseppe , Pirinu Federica , Marini Maria Giuseppina , Mingoia Maura , Frau Jessica , Lorefice Lorena , Fronza Marzia , Carmagnini Daniele , Carta Elisa , Orrù Valeria , Uzzau Sergio , Solla Paolo , Loi Federica , Devoto Marcella , Steri Maristella , Fiorillo Edoardo , Floris Matteo , Zarbo Ignazio Roberto , Cocco Eleonora , Cucca Francesco 
Published: December 2021

ObjectivesVaccination against COVID-19 is highly recommended to patients affected by multiple sclerosis (MS); however, the impact of MS disease-modifying therapies (DMTs) on the immune response following vaccination has been only partially investigated. Here, we aimed to elucidate the effect of DMTs on the humoral immune response to mRNA-based anti-SARS-CoV-2 vaccines in MS patients.MethodsWe obtained sera from 912 Sardinian MS patients and 63 healthy controls 30 days after the second dose of BNT162b2 vaccine and tested them for SARS-CoV-2 response using anti-Spike (S) protein-based serology. Previous SARS-CoV-2 infection was assessed by anti-Nucleocapsid (N) serology. Patients were either untreated or undergoing treatment with a total of 13 different DMTs. Differences between treatment groups comprised of at least 10 patients were assessed by generalized linear mixed-effects model. Demographic and clinical data and smoking status were analyzed as additional factors potentially influencing humoral immunity from COVID-19 vaccine.ResultsMS patients treated with natalizumab, teriflunomide, azathioprine, fingolimod, ocrelizumab, and rituximab showed significantly lower humoral responses compared to untreated patients. We did not observe a statistically significant difference in response between patients treated with the other drugs (dimethyl fumarate, interferon, alemtuzumab and glatiramer acetate) and untreated patients. In addition, older age, male sex and active smoking were significantly associated with lower antibody titers against SARS-CoV-2. MS patients previously infected with SARS-CoV-2 had significantly higher humoral responses to vaccine than uninfected patients.ConclusionHumoral response to BNT162b2 is significantly influenced by the specific DMTs followed by patients, as well as by other factors such as previous SARS-CoV-2 infection, age, sex, and smoking status. These results are important to inform targeted strategies to prevent clinically relevant COVID-19 in MS patients.
Functionally Active Antibodies to the Angiotensin II Type 1-Receptor Measured by a Luminometric Bioassay Do Not Correlate With Clinical Manifestations in Systemic Sclerosis: A Comparison With Antibodies to Vascular Receptors and Topoisomerase I Detected by ELISA
Authors: Bankamp Lukas , Preuß Beate , Pecher Ann-Christin , Beucke Nicola , Henes Jörg , Klein Reinhild 
Published: December 2021

Objectives1) To detect functionally active antibodies(abs) to the angiotensin II type-1-receptor (AT1R) by a novel luminometric assay. 2) To assess their prevalence in systemic sclerosis (SSc), other collagen disorders, as well as in further chronic inflammatory disorders including autoimmune, toxic and chronic viral diseases. 3) To compare these abs with anti-AT1R antibodies by ELISA as well as with antibodies to endothelin-type-A receptors (ETA1) and to topoisomerase I (topo-I) with respect to their specificity and clinical relevance.MethodsSera from 98 SSc-patients, 110 patients with other chronic inflammatory rheumatic disorders, 97 patients with autoimmune liver diseases, 57 patients with toxic or chronic viral liver diseases and 36 healthy controls were analyzed. A luminometric bioassay was established with Huh-7-cells constitutively expressing the AT1R. Patients’ sera were also tested by commercially available ELISA for anti-AT1R, -ETA1- and by an in-house ELISA for anti–topo-I-abs.ResultsFifty-two percent of the SSc-patients had functionally active anti-AT1R-abs with stimulatory (34%) or inhibitory capacity (18%). They were present also in up to 59% of patients with other rheumatic diseases but only 22% of healthy individuals (sensitivity 52%, specificity 53%). The functionally active antibodies detected by the luminometric assay did not correlate with anti-AT1R-, -ETA1- or -topo-I-abs measured by ELISA, but there was a strong correlation between anti-topo-I-, AT1R-, and -ETA1-ab reactivity measured by ELISA. Sensitivities of 55%, 28% and 47% and specificities of 66%, 87%, and 99% were calculated for these anti-AT1R-, -ETA1-, and anti-topo-I-abs, respectively. Functionally active abs did not correlate with disease severity or any organ manifestation. In contrast, abs to topo-I, AT1R, and ETA1 were associated with digital ulcers, pulmonary- and esophageal manifestation.ConclusionsFunctionally active anti-AT1R-abs can be detected in SSc-patients but do not correlate with disease activity. They are not specific for this disease and occur also in other autoimmune disorders and even viral or toxic diseases. Also, the vascular antibodies detected by ELISA are not SSc-specific but correlated with disease manifestations. In contrast, anti-topo-I-abs were confirmed to be a highly specific biomarker for both, diagnosis and organ manifestations of SSc.