bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural Basis for Membrane Recruitment of ATG16L1 by WIPI2 in Autophagy
Authors: Strong Lisa M. , Chang Chunmei , Alexander Boecker C. , Flower Thomas G. , Buffalo Cosmo Z. , Ren Xuefeng , Stavoe Andrea K. H. , Holzbaur Erika L. F. , Hurley James H. 
Published: May 2021

ABSTRACTAutophagy is a cellular process that degrades cytoplasmic cargo by engulfing it in a double membrane vesicle, known as the autophagosome, and delivering it to the lysosome. The ATG12–5-16L1 complex is responsible for conjugating members of the ubiquitin-like ATG8 protein family to phosphatidylethanolamine in the growing autophagosomal membrane, known as the phagophore. ATG12–5-16L1 is recruited to the phagophore by a subset of the phosphatidylinositol 3-phosphate-binding seven bladed β-propeller WIPI proteins. We determined the crystal structure of WIPI2d in complex with the WIPI2 interacting region (W2IR) of ATG16L1 comprising residues 207-230 at 1.85 Å resolution. The structure shows that the ATG16L1 W2IR adopts an alpha helical conformation and binds in an electropositive and hydrophobic groove between WIPI2 β-propeller blades 2 and 3. Mutation of residues at the interface reduces or blocks the recruitment of ATG12–5-16L1 and the conjugation of the ATG8 protein LC3B to synthetic membranes. Interface mutants show a decrease in starvation-induced autophagy. Comparisons across the four human WIPIs suggest that WIPI1 and 2 belong to a W2IR-binding subclass responsible for localizing ATG12–5-16L1 and driving ATG8 lipidation, whilst WIPI3 and 4 belong to a second W34IR-binding subclass responsible for localizing ATG2, and so directing lipid supply to the nascent phagophore. The structure provides a framework for understanding the regulatory node connecting two central events in autophagy initiation, the action of the autophagic PI 3-kinase complex on the one hand, and ATG8 lipidation on the other.
Effect of narrow pulse width laser cleaning on corrosion resistance of A5083-H111 aluminum alloy
Authors: Wang Feisen , Ai Sifei , Wang Qian , Cheng Yinfen , Huang Haiqi , Cai Chuang , Xie Di , Chen Hui , Hu Wei 
Published: May 2021

Purpose
The purpose of this paper is to promote the corrosion resistance of the 5083-111H aluminum alloy by laser cleaning.

Design/methodology/approach
Laser with 2 ns pulse width was adopted in this project and the corrosion resistance of cleaned samples was tested by copper-accelerated salt spray (CASS). The surface morphology, elemental composition and distribution were then characterized by SEM. Moreover, surface morphology, elemental composition and distribution were also tested.

Findings
Results suggested a higher corrosion resistance was successfully obtained by laser cleaning. Compared with samples cleaned by 2000 grit sandpaper, mechanical cleaning resulted in a 53% larger height difference between the peak and valley. The content of the oxygen is 8.85% on the surface cleaned mechanically and the distribution is dependent on the distribution of aluminum whereas that of the laser cleaning sample is 24.41% and the distribution existed even in the Al-poor area.

Originality/value
In this project, the 2-ns laser cleaning was proved to have the capability to remove the oxide layer on the aluminum alloy surface while retaining an excellent corrosion resistance and smooth surface. Meanwhile, a thorough elemental distribution and smaller grain size lead to a smaller difference in elemental concentration. This retards the diffusion of oxygen into the substrate and hence increases the corrosion resistance of the surface.
Implementation of a multi-layer radiation propagation model for simulation of microwave heating in hydrate reservoirs
Authors: Gupta Akash K. , Yadav Rahul , Das Malay K. , Panigrahi Pradipta K. 
Published: May 2021

Purpose
This paper aims to present the implementation of a multi-layer radiation propagation model in simulations of multi-phase flow and heat transfer, for a dissociating methane hydrate reservoir subjected to microwave heating.

Design/methodology/approach
To model the induced heterogeneity due to dissociation of hydrates in the reservoir, a multiple homogeneous layer approach, used in food processes modelling, is suggested. The multi-layer model is incorporated in an in-house, multi-phase, multi-component hydrate dissociation simulator based on the finite volume method. The modified simulator is validated with standard experimental results in the literature and subsequently applied to a hydrate reservoir to study the effect of water content and sand dielectric nature on radiation propagation and hydrate dissociation.

Findings
The comparison of the multi-layer model with experimental results show a maximum difference in temperature estimation to be less than 2.5 K. For reservoir scale simulations, three homogeneous layers are observed to be sufficient to model the induced heterogeneity. There is a significant contribution of dielectric properties of sediments and water content of the reservoir in microwave radiation attenuation and overall hydrate dissociation. A high saturation reservoir may not always provide high gas recovery by dissociation of hydrates in the case of microwave heating.

Originality/value
The multi-layer approach to model microwave radiation propagation is introduced and tested for the first time in dissociating hydrate reservoirs. The multi-layer model provides better control over reservoir heterogeneity and interface conditions compared to existing homogeneous models.
Citizen journalism practices during COVID-19 in spotlight: influence of user-generated contents about economic policies in perceiving government performance
Authors: Raza Syed Hassan , Emenyeonu Ogadimma C. , Yousaf Muhammad , Iftikhar Moneeba 
Published: May 2021

Purpose
Citizen journalism practices through social networking sites are increasingly becoming an imperative source of public opinion formation. Given the increase in the volume of information sharing on social media during COVID-19, this study aims to grasp the largely unknown interaction of the individual’s trust in citizen journalism practices and public perception formulation. Drawing on this idea, the study has twofold objectives: first, to examine the influence of user-generated information about economic policies of government during COVID-19 as the antecedent of public perception about government performance and second, to identify the moderating role of trust in citizen journalism practices during COVID-19 through social networking sites.

Design/methodology/approach
The study used a survey method and a sample of 464 adults were collected through an online administrated questionnaire.

Findings
The findings specify that user-generated content that is pro-government economic policies during COVID-19 positively influenced the perception of government performance. On the other hand, user-generated information that criticized government economic policies had a negative influence on public perception.

Originality/value
This study seeks to intensify the understudied phenomenon of how nature and source of the information could interact to influence one’s information processing during a crisis such as pandemic COVID-19. Furthermore, only a little research has been conducted in this area focusing on two mechanisms, namely; citizen journalism and trust in social media user-generated information about prevailing economic insecurities during crisis provided through citizen journalism.
Characterizing an information environment for supporting learning
Authors: Campana Kathleen 
Published: May 2021

Purpose
This study aims to offer insights into the presence and nature of an information environment provided for young children to support their learning and explore how an information environment for young children can be characterized.

Design/methodology/approach
Observations of video-recorded public library storytimes were used to investigate the presence and nature of an information environment for young children’s learning.

Findings
The observations revealed that storytimes provide a rich, multimodal information environment where information is shared with young children and they are encouraged to interact with it in a variety of ways. The storytime participants take on several different roles that help to foster and sustain the information environment.

Originality/value
This study tests the applicability of Eisenberg and Small’s (1993) information-based education framework for exploring an information environment and recommends revisions to improve the framework’s effectiveness for characterizing information environments for young children.
BIM-based time-cost optimization of a large-span spatial steel structure in an airport terminal building
Authors: Yu Jingyu , Wang Jingfeng , Hua Zhengmao , Wang Xingxing 
Published: May 2021

Purpose
Airports are booming in China, to enlarge their capacities and stimulate economic development. Large-span spatial steel structures are commonly used in the terminal buildings of airport projects. Their advantages include prefabrication, strength, usability, adaptability and aesthetic quality. To manage large-span spatial steel structure projects, building information modeling (BIM) is recommended. Although there are plenty of studies on BIM application in steel structure projects, it is still rare to apply BIM to optimize the schedule and cost of steel structures, especially for airport projects.

Design/methodology/approach
This paper aims to develop a framework in which BIM and a time-cost optimization model are integrated to optimize construction costs and the duration of large-span spatial steel structure projects. A real case study was conducted to verify the feasibility of the BIM-based time-cost optimization model in an airport terminal building, which was built with a large-span spatial steel structure.

Findings
The results preliminarily support the reliability of the proposed BIM-based time-cost optimization model. The BIM-based time-cost optimization model will benefit construction planning for professionals and enrich relevant research on the application of BIM in large-span spatial steel structure projects.

Originality/value
The steel structure is difficult to control budgets and progress. This paper is expected to be adopted for optimizing the time and cost plans for projects involving steel structures in airport terminal buildings.
Effects of learning culture and teamwork context on team performance mediated by dynamic capability
Authors: Gonzalez Rodrigo Valio Dominguez 
Published: May 2021

PurposeThis study aims to investigate the relationship between learning culture and teamwork context based on the mediating role played by dynamic capability in manufacturing teams of the industrial sector.Design/methodology/approachIt proposes that dynamic capability is a key element for improving the performance of teams, which, in turn, is positively affected by learning culture and teamwork context. This study is based on data from a survey of 201 companies in the Brazilian industrial sector with manufacturing teams, and followed the partial least squares approach to model the structural equation that was used for data analysis.FindingsThe results indicate that dynamic capability has a strong positive influence on team performance, and also that, despite learning culture and teamwork context having no direct association with performance, they offer contributions mediated by dynamic capability.Research limitations/implicationsThis study includes a reduced sample regarding the population of Brazilian industrial companies, being restricted to only one sector of activity. Future studies may obtain larger samples by working with different sectors in different countries.Practical implicationsThis article alerts managers to the importance of dynamic capability for improving the performance of teams, and points out the role played by learning culture and teamwork context in this relationship.Originality/valueThis research presents new insights into how dynamic capability contributes to the performance of teams, based on antecedent factors (learning culture and teamwork context).
Forecasting annual foreign tourist arrivals to China by incorporating firefly algorithm into fractional non-homogenous discrete Grey model
Authors: Tang Xiaozhong , Xie Naiming , Hu Aqin 
Published: May 2021

Purpose
Accurate foreign tourist arrivals forecasting can help public and private sectors to formulate scientific tourism planning and improve the allocation efficiency of tourism resources. This paper aims to address the problem of low prediction accuracy of Chinese inbound tourism demand caused by the lack of valid historical data.

Design/methodology/approach
A novel hybrid Chinese inbound tourism demand forecasting model combining fractional non-homogenous discrete grey model and firefly algorithm is constructed. In the proposed model, all adjustable parameters of the fractional non-homogenous discrete grey model are optimized simultaneously by the firefly algorithm.

Findings
The data sets of annual foreign tourist arrivals to China are used to verify the validity of the proposed model. Experimental results show that the proposed method is effective and can be used as a useful predictor for the prediction of Chinese inbound tourism demand.

Originality/value
The method proposed in this paper is effective and can be used as a feasible approach for forecasting the development trend of Chinese inbound tourism.
Can corporate social responsibility enhance organizational image and commitment in the ocean freight forwarding industry?
Authors: Yang Ching-Chiao , Lai Po-Lin , Zhu Xiaonan 
Published: May 2021

PurposeIn the past few decades, the concept of corporate social responsibility (CSR) has received substantial interest in the competitive business environment. This study aims to empirically examine the impact of CSR on corporate image, organizational commitment and organizational performance in ocean freight forwarders.Design/methodology/approachFive critical CSR dimensions were identified based on factor analysis: consumer interests, employee interests, environmental management, disclosure and corporate commitment and sponsorship. Structural equation modelling was subsequently performed to examine the hypothesized relationships among CSR, corporate image, organizational commitment and organizational performance.FindingsResults indicated that CSR had significantly positive effects on corporate image and organizational commitment, whereas corporate image was positively related to organizational commitment and organizational performance, respectively. Organizational commitment was also positively related to organizational performance. However, CSR did not have a significant direct effect on organizational performance.Research limitations/implicationsThis study intended to conduct a survey on logistics service providers; however, due to the limited availability of research on ocean freight forwarding service providers, the present sample was limited to ocean freight forwarding enterprises.Originality/valueFrom a theoretical perspective, this study contributes to the field by identifying the important dimensions of CSR and their effects on corporate image, organizational commitment and organizational performance. Particularly, it demonstrated the effect of CSR on ocean freight forwarding employees’ organizational commitment.
Do anchor investors affect long run performance? Evidence from Indian IPO markets
Authors: Kumar Abhishek , Sahoo Seshadev 
Published: May 2021

Purpose
Anchor investor (AI) regulation was introduced in 2009 by the Indian market regulator Securities and Exchange Board of India to facilitate the price discovery process during the book-building mechanism. This study aims to examine the aftermarket pricing performance of initial public offering (IPO) firms over the long-run period of up to 36 months after the listing date in the anchor investor regime.

Design/methodology/approach
The post-issue performance of 129 Indian IPOs issued from 2009 to 2014 is studied by using buy and hold abnormal returns, cumulative abnormal returns and wealth relatives approaches. This study presents the aftermarket performance indicators of Indian IPOs along with the comparative analysis between anchor-backed and non-anchor-backed IPO categories. Using multiple regression analysis, this study identifies the firm-level variables and issue characteristics that can explain long-term IPO performance.

Findings
This study reports that Indian IPOs continue to underperform in the long run in the anchor regulation era as well. However, anchor-backed IPOs are reported to underperform lesser than the IPOs not backed by anchor investment. Additionally, this study documents that the variables, i.e. offer size, grade, post-issue promoter holding and IPOs issued during hot IPO periods, are significant in explaining the 36-month aftermarket performance.

Originality/value
This study investigates the long-run aftermarket pricing performance of anchor affiliated IPOs in the Indian market context. Thus, it contributes to the limited primary markets’ research from emerging economies. Further, the results provide fresh evidence reaffirming the credibility of AI as an institutional investor for attestation of quality of the issues.
Don’t count them out: PhD skills development and careers in industry
Authors: Mitic Radomir Ray , Okahana Hironao 
Published: May 2021

Purpose
The purpose of this study is to identify what skills gained during PhD study are linked with preparation and differences between industry and academic positions.

Design/methodology/approach
Using student-level data from nearly 2,400 early career PhD alumni from 50 US PhD granting institutions, this study uses a generalized ordered logit model with partial proportional odds to test the main and conditional effects of 14 areas of skill development on perceptions of career preparation.

Findings
This study contributes empirical evidence to show that research skills and communicating with non-technical audiences are positively linked with job preparation.

Practical implications
The combination of sophisticated research and noncognitive skills promotes the idea of a well-rounded PhD – a highly skilled and versatile researcher that can interact in both academic and industry settings – as a goal of doctoral education. The knowledge gained from this study will assist scholars and graduate educators, including faculty advisors, program directors, graduate deans, graduate education professionals and career development professionals to reconceptualize professional preparation for work in industry.

Social implications
For-profit businesses, particularly start-up companies, are vital for economic development and many require PhD-level employees across research and management roles. Developing PhDs with the appropriate skills for industry will better align higher education and economic interests.

Originality/value
The wide scope of doctoral institutions allows for a quantitative approach not appropriate for single-institution case studies of doctoral career pathways research.
A sustainable approach in using construction and demolition waste materials in concrete
Authors: Quedou Pritish Gupta , Wirquin Eric , Bokhoree Chandradeo 
Published: May 2021

Purpose
The purpose of this paper is to investigate the potential use of construction and demolition waste materials (C&DWM) as an alternative for natural fine aggregates (NFA), in view to solve the disposal problems caused due to landfills. In addition, to evaluate its suitability as a sustainable material, mechanical and durability properties have been performed on different proportions of concrete blending and the results recorded were compared with the reference concrete values.

Design/methodology/approach
In this research, the NFA were replaced at the proportion of 25%, 50%, 75% and 100% of C&DWM with a constant slump range of 130 mm–150 mm. This parameter will assess the consistency of the fresh concrete during transportation process. The characteristics of the end product was evaluated through various tests conducted on hardened concrete samples, namely, compressive strength, flexural strength, depth of penetration of water under pressure, rapid chloride penetration test, carbonation test and ultrasonic pulse velocity (UPV) test. All results recorded were compared with the reference concrete values.

Findings
The results demonstrated that the use of C&DWM in concrete portrayed prospective characteristics that could eventually change the concept of sustainable concrete. It was noted that the compressive and flexural strength decreased with the addition of C&DWM, but nevertheless, a continuous increase in strength was observed with an increase in curing period. Moreover, the increase in rapid chloride penetration and decrease in UPV over time period suggested that the concrete structure has improved in terms of compactness, thus giving rise to a less permeable concrete. The mechanical tests showed little discrepancies in the final results when compared to reference concrete. Therefore, it is opined that C&DWM can be used effectively in concrete.

Originality/value
This study explores the possible utilisation of C&DWM as a suitable surrogative materials in concrete in a practical perspective, where the slump parameter will be kept constant throughout the experimental process. Moreover, research on this method is very limited and is yet to be elaborated in-depth. This approach will encourage the use of C&DWM in the construction sector and in the same time minimise the disposal problems caused due to in landfills.
The circular RNA circ_GRHPR promotes NSCLC cell proliferation and invasion via interactions with the RNA‐binding protein PCBP2
Authors: Hou Yanyan , Lin Jiafei , Wang Danyang , Zhang Yingwei , Liang Qiuli , Chen Ning , Wu Jiemin , Wu Weiqi , Liu Xiangfan , Ni Peihua 
Published: May 2021

AbstractAs the most common malignancy, lung cancer is characterised by high rates of occurrence and mortality. Although circular RNAs (circRNAs) are known to act as important regulators in cancer, their role in lung cancer remains poorly understood. In this study, circ_GRHPR expression was found to be significantly upregulated in the serum of five patients with non‐small cell lung cancer (NSCLC), compared to that in healthy controls. It is expressed at high levels in NSCLC cell lines, as revealed by qRT‐PCR analysis. Functionally, we demonstrated that circ_GRHPR promotes NSCLC proliferation and invasion in vitro and in vivo by cell proliferation, transwell, cell cycle, and tumour‐forming assays. Mechanistically, RNA pull‐down and RNA immunoprecipitation assays showed that circ_GRHPR interacts with the RNA‐binding protein poly(rC)‐binding protein 2 (PCBP2) and regulates its subcellular localisation by forming the circ_GRHPR/PCBP2 complex, localizing PCBP2 mainly in the cytoplasm and reducing the proportion found in the nucleus. Furthermore, we demonstrated that four‐and‐a‐half LIM‐only protein 3 (FHL3) is a tumour‐stimulating factor in NSCLC that interacts with and is influenced by PCBP2. Circ_GRHPR increased FHL3 expression in the nucleus of NSCLC cells by decreasing PCBP2 expression therein and promoting the proliferation and invasion of NSCLC cells. Therefore, our study identified that circ_GRHPR promotes NSCLC proliferation and invasion, providing a possible explanation for its mechanism of action.