bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic Behavior of Innovative Hybrid CLT-steel Shear Wall for Mid-Rise Buildings.
Authors: Enrique Tulio Carrero , Montaño Jairo , Berwart Sebastián , María Hernán Santa , Guindos Pablo 
Published: February 2021

Abstract
This paper examines the seismic behavior of CLT-steel hybrid walls at six- and ten-story heights to increase seismic force resistance compared to a conventional wooden wall. The ultra-strong shear walls proposed in this paper are called Framing Panel Shear Walls (FPSW), which are based on a robust articulated steel frame braced with CLT board panels and steel tendons. Timber structures are well-known for their ecological benefits, as well as their excellent seismic performance, mainly due to high strength-to-weight ratio compared to steel and concrete ones, flexibility, and redundancy. However, in order to meet the requirements regarding the maximum inter-story drifts prescribed in seismic design codes, a challenging engineering problem emerges, because sufficiently resistant, rigid and ductile connections and lateral assemblies are not available for timber to meet both the technical and economical restrictions. Therefore, it is a necessity to develop strong and cost-effective timber-based lateral systems, in order to become a real alternative to mid- and high-rises, especially in seismic countries. In this investigation, the dynamic response of cross-laminated timber (CLT) combined with hollow steel profiles has been investigated in shear wall configuration. After experimental work, an investigation was also carried out into numerical modelling for simulating the cyclic behavior of a hybrid FPSW wall and the spectral modal analysis of a six- and a ten-story buildings with FPSW. A FPSW shear wall can double the capacity and stiffness.
Antioxidant metabolites from riparian fungal endophytes improve the tolerance of rice seedlings to flooding
Authors: Xue Yanhong , Liu Chengxiong , Bai Xiaoxuan , Cheng Fan , Chen Jianfeng , liu shiping 
Published: February 2021

Abstract
Endophytic fungi have the potential to enhance plant resistance to various stresses and promote the ecological adaptation of the hosts. To evaluate the effects of the riparian endophytes on rice seedlings to flooding tolerance, here we screened out two endophytes from the plant Myricaria laxiflora growing in the Yangtze River zone. Through morphological characteristics and rDNA ITS (internal transcriber region) sequence, the two strains were respectively identified as Aspergillus fumigatus and Chaetomium globosum. Metabolites derived from both fungi were capable of increasing tolerance to flooding. Systematic separation and purification coupled to bioassays revealed that two natural antioxidants, Z-N-4-hydroxystyryl formamide (NFA) and chaetoglobosin A (CheA), were effective for alleviating flooding stress. Both NFA and CheA inhibited the production of factors such as malondialdehyde, superoxide dismutase, ethanol dehydrogenase, and NADPH oxidase that are associated with oxidative stress induced by flooding. Gene expression analyses of NADPH oxidase families indicated that OsRbohB could be involved in conferring flooding tolerance mediated by the two natural antioxidants. These findings contribute to understanding the role of the natural antioxidants in riparian endophytic fungi, and providing a basis for improvement of flooding tolerance of rice and other crop plants through the antioxidants of the fungal endophytes.
Research on prediction model of drilling force in CFRP internal chip removal hole drilling based on SVR
Authors: Xu Chengyang , Songyang Yao , Gongdong Wang , Yiwen Wang , Jiazhong Xu 
Published: February 2021

Abstract
Drilling force is the main factor affecting the drilling quality and tool wear of carbon fiber reinforced resin matrix composites (CFRP), selecting the appropriate process parameters can effectively control the drilling force, improve the drilling quality and tool life. In this paper, in order to accurately predict and effectively control the drilling force under the process of internal chip removal hole drilling: Firstly, based on the application of support vector regression (SVR) in data analysis, the theory of the prediction model of drilling force in CFRP is given; Secondly, on the basis of the above theories, the experiment of chip removal in CFRP is designed and completed, designed and completed the CFRP internal chip removal processing drilling experiment, it provides preparation for the solution of parameters in the subsequent model; Again, based on the above theoretical analysis and experimental data, under the premise of choosing the appropriate kernel function and loss function, the sequential minimum optimization (SMO) algorithm is applied to solve the unknown parameters in the model, to complete the construction of the SVR-based CFRP internal chip removal machining drilling force prediction model; Finally, using the constructed predictive model, it is predicted that when CFRP internal chip removal hole machining is studied, The relationship between cutting parameters (speed, feed), tool parameters (drill diameter, peak angle, relief angle) and suction parameters (negative pressure) and axial force.
Incidence and Risk Factors of Proximal Junctional Kyphosis in Elderly Patients Over 65 Years of Age with Degenerative Spinal Diseases
Authors: Ding Junzhe , Kong Chao , Zhu Weiguo , Lu Shibao 
Published: February 2021

Abstract
Background. The mechanisms and risk factors for proximal junctional kyphosis of elderly patients may differ from those of non-elderly patients. The risk factors for PJK in the elderly population remain unclear. Methods. The present study enrolled elderly DSD patients over 65 years of age who underwent thoracolumbar fusion with no less than 3 levels fused. All patients underwent CT and MRI scans preoperatively, and full spine standing X-ray preoperatively, postoperatively and during follow-up with a minimum follow-up of 18 month. Paraspinal muscle cross-sectional area(CSA) and paraspinal muscle fatty infiltration(FI) of erector spinae(ES) and multifidus muscle(MF), LL, PI, PT, SS, PI-LL and vertebra CT HU value were measured. Radiological PJK was defined as a sagittal Cobb angle between the UIV and the two levels above the UIV (UIV+2) of 10° or greater and at least 10° greater than the preoperative measurement. Parameters were compared between PJK and Non-PJK patients.Result. A total of 259 patients were enrolled. The prevalence of PJK was 35.9%. Compared with Non-PJK group, PJK group had significantly older age at surgery, greater BMI, lower vertebra CT value and greater PI and a larger PI-LL mismatch. Both erector spinae(ES) and multifidus muscle(MF) relative cross-sectional area(rCSA) of PJK patients were significantly smaller, the ES and MF fatty infiltration(FI) were significantly greater than the Non-PJK patients. Older age at surgery, greater BMI, greater PI, smaller MF rCSA, greater ES and MF FI and smaller CT value were independent risk factors for PJK in elderly patient population.Conclusions. For elderly patients with DSD, PJK is a commonly seen complication. Higher age at surgery, larger BMI, significant paraspinal muscle degeneration and low bone mineral density are risk factors for PJK. Appropriate preoperative and postoperative measures are beneficial for reducing the risk of PJK in the elderly.
Thermochemical Aerobic Oxidation Catalysis in Water Proceeds via Coupled Electrochemical Half-Reactions
Authors: Ryu Jaeyune , Bregante Daniel , Howland William , Bisbey Ryan , Kaminsky Corey , Surendranath Yogesh 
Published: February 2021

Abstract
Heterogeneous aqueous-phase aerobic oxidations are an important emerging class of catalytic transformations, particularly for upgrading next generation bio-derived substrates. The mechanism of these reactions and the precise role of O2 in particular remains unclear. Herein, we test the hypothesis that thermochemical aerobic oxidation proceeds via two coupled electrochemical half-reactions for oxygen reduction and substrate oxidation. We collect electrochemical and thermochemical data on common noble metal catalysts under identical reaction/transport environments, and find that the electrochemical polarization curves of the O2 reduction and the substrate oxidation half-reaction closely predict the mixed potential of the catalyst measured in operando during thermochemical catalysis across 13 diverse variables spanning reaction conditions, catalyst composition, reactant identity, and pH. Additionally, we find that driving the oxidation half-reaction reaction electrochemically in the absence of O2 at the mixed potential leads to very similar rates and selectivities as for the thermochemical reaction in all cases examined. These findings strongly indicate that the role of O2 in thermochemical aerobic oxidation is solely as an electron scavenger that provides an incipient electrochemical driving force for substrate oxidation. These studies provide a quantitative and predictive link between thermochemical and electrochemical catalysis, thereby enabling the rational design of new thermochemical liquid-phase aerobic oxidation schemes by applying the principles of electrochemistry.
A methodological review to develop a list of bias items used to assess reviews incorporating network meta-analysis: Protocol and rationale
Authors: Lunny Carole , Veroniki Areti Angeliki , Tricco Andrea , Dias Sofia , Hutton Brian , Salanti Georgia , Wright James M. , White Ian R. , Whiting Penny 
Published: February 2021

Abstract
Introduction: Systematic reviews with network meta-analysis (NMA; i.e., multiple treatment comparisons, indirect comparisons) have gained popularity and grown in number due to their ability to provide comparative effectiveness of multiple treatments for the same condition. The methodological review aims to develop a list of items relating to biases in reviews with NMA. Such a list will inform a new tool to assess the risk of bias in NMAs, and potentially other reporting or quality checklists for NMAs which are being updated.Methods and Analysis: We will include articles that present items related to bias, reporting, or methodological quality, articles assessing the methodological quality of reviews with NMA, or papers presenting methods for NMAs. We will search Ovid MEDLINE, the Cochrane library, and difficult to locate/unpublished literature. Once all items have been extracted, we will combine conceptually similar items, classifying them as referring to bias or to other aspects of quality (e.g. reporting). When relevant, reporting items will be re-worded into items related to bias in NMA review conclusions, and then re-worded as signalling questions. Ethics and Dissemination: No ethics approval was required. Patients, healthcare providers and policy makers need the highest quality evidence to make decisions about which treatments should be used in healthcare practice. Being able to critically appraise the findings of systematic reviews that include NMA is central to informed decision-making in patient care.
Impact of the COVID-19 Pandemic on Willingness to Adopt Healthy Dietary Habits in China
Authors: Xu Ying , Li Zhixue , Yu Weijun , Liu Ting , Liu Zheng , Yang Liuna , Xie Ailun , Qian Zhenzhu , Zhao Rencheng , Guo YanFang , Chen Jialong 
Published: February 2021

Abstract
Background: To investigate impact of the 2019 novel coronavirus disease (COVID-19) pandemic on willingness to adopt healthy dietary habits in China. Methods: A survey was carried out, and subjective perception of impact due to COVID-19 and willingness to change dietary habits were obtained. Results: A total of 22,459 subjects were derived from China, with an average age of 27.9±7.8 years old. Of them, the mean score of willingness to adopt healthy dietary habits was 2.2 (ranges from -9 to 9). Multivariate regression analysis showed that the impact of the COVID-19 pandemic (epidemic concern, impact of psychology, impact of work or study) are associated with a higher score of willingness to adopt healthy dietary habits among female, the older, on-medical worker, and individuals married or with higher education level, normal BMI. Conclusions: There was a positive improvement to a proper diet, so the changing features of diets should be considered in nutritional interventions for maintaining health, and prevention and control COVID-19 during the pandemic period.
Factors Associated with SARS-CoV2 Infection and Care Pathways Among the Most Vulnerable Populations Living in Marseille: A Case Control Study
Authors: Alsaïdi Ismaïl , Santos Frédéric De Sousa , Plard Bérangère , Janvier Elise , Tinland Aurélie , Hafni Abdelmajid , Mosnier Emilie 
Published: February 2021

Abstract
Background: Mainland France has been seriously affected by the Covid-19 epidemic, which has brought significant and unexpected morbidity and mortality. Precarious people cared for in accommodation centers are particularly at risk of infection because of collective housing, their dependence on the support system and therefore their difficulty in applying barrier measures. These populations are also subject to a risk of more severe infections or a delay in seeking treatment. This study aims to identify the factors associated with SARS-CoV2 infection in the most vulnerable populations in Marseille.Methods: The sample on which the study was carried out consists of association users, whether or not presenting a symptomatology suggestive of Covid-19, and routinely treated between March 2020 and May 2020. Through univariate and multivariate analyzes, we studied the influence of several variables on morbidity attributable to SARS-CoV2. Results: 64 participants were enrolled in the study with 29 cases and 35 control subject. Median age was 21.16 years old with a younger age in the case group (p < 0.005). Sex ratio was 7. Risk factors of SARS-CoV2 in multivariate analysis were living in a shared apartment and a low compliance for distancing measure. Participants presented frequent mental health problems such as anxiety. Conclusions: The allocation of housing to structures involved with the most precarious people appears to be a decisive factor in the fight against the spread of SARS-CoV2 and therefore deserves more attention from public authorities.
Crosstalk between lymphoid and myeloid cells orchestrates glioblastoma immunity through Interleukin 10 signaling
Authors: Ravi Vidhya , Neidert Nicolas , Will Paulina , Joseph Kevin , Maier Julian , Kückelhaus Jan , Vollmer Lea , Goeldner Jonathan , Behringer Simon , Scherer Florian , Boerries Melanie , Follo Marie , Weiss Tobias , Delev Daniel , Kernbach Julius , Franco Pamela , Schallner Nils , Dierks Christine , Carro Maria Stella , Hofmann Ulrich , Fung Christian , Sankowski Roman , Prinz Marco , Beck Jürgen , Schnell Oliver , Heiland Dieter 
Published: February 2021

Abstract
Despite recent advances in cancer immunotherapy, its efficacy in Glioblastoma (GBM) is limited due to poor understanding of molecular states and cellular plasticity of immune cells within the tumor microenvironment. Here, we combined spatial and single-cell transcriptomics of 47.284 immune cells, to map the potential cellular interactions leading to the immunosuppressive microenvironment and dysfunction of T cells. Computational approach identified a subset of IL10 releasing HMOX1+ myeloid cells which activates transcriptional programs towards a dysfunctional state in T cells, and was found to be localized within mesenchymal dominated subregions of the tumor. These findings were further validated by a human ex-vivo neocortical GBM model (n=6) coupled with patient derived peripheral T-cells. Finally, the dysfunctional transformation of T cells was shown to be rescued by JAK/STAT inhibition in both our model and in-vivo. We strongly believe that our findings would be the stepping stone towards successful development of immunotherapeutic approaches in GBM.
Repeat breast-conserving treatment of ipsilateral breast cancer recurrence: a nationwide survey amongst breast surgeons and radiation oncologists in the Netherlands
Authors: Walstra Coco J.E.F. , Schipper Robert-Jan , Riet Yvonne van , Toorn Peter-Paul van der , Smidt Marjolein L. , Sangen Maurice J.C. van der , Voogd Adri C. , Nieuwenhuijzen Grard A.P. 
Published: February 2021

Abstract
BACKGROUND In line with the paradigm to minimize surgical morbidity in patients with primary breast cancer, there is increasing evidence for the safety of a repeat breast-conserving treatment (BCT) of an ipsilateral breast tumor recurrence (IBTR) in selected patients. The conditions for the feasibility of a repeat BCT vary widely in literature. In clinical practice, many physicians have ongoing concerns about the oncological safety and possible toxicity of repeat BCT.AIM To investigate the attitude of Dutch breast surgeons and radiation oncologists towards repeat BCT and to report on their experiences with, objections against, and perceived requirements to consider a repeat BCT in case of IBTR.PATIENTS AND METHODS An online survey consisting of a maximum of 26 open and multiple choice questions about repeat BCT for IBTR was distributed amongst Dutch breast surgeons and radiation oncologists.RESULTS Forty-nine surgeons representing 49% of Dutch hospitals and 20 radiation oncologists representing 70% of Dutch radiation oncology centers responded. A repeat BCT was considered feasible in selected cases by 28.7% of breast surgeons and 55% of radiation oncologists. The most important factors to consider a repeat BCT for both groups were the patient’s preference to preserve the breast and surgical feasibility of a second lumpectomy. Arguments against a repeat BCT were based on the perceived unacceptable toxicity and cosmesis of a second course of radiotherapy. The technique of preference for re-irradiation would be partial breast irradiation (PBI) according to all radiation oncologists. Differentiating between new primary tumours (NPT) and true recurrences (TR) was reported to be done by 57.1% of breast surgeons and 60% of radiation oncologists. The most important reason to differentiate between NPT and TR was to establish prognosis and to consider whether a repeat BCT would be feasible.CONCLUSION An increasing number of Dutch breast cancer specialists is considering a repeat BCT feasible in selected cases, at the patient’s preference and with partial breast re-irradiation.
Wnt/β-catenin pathway proteins in end-stage renal disease
Authors: Al-Hakeim Hussein Kadhem , Asad Halah Nori , Maes Michael 
Published: February 2021

Abstract
Background. Wnt-pathway proteins play a vital role in kidney development and defects in the Wnt-pathway are associated with kidney disorders. However, the knowledge on the role of Wnt/β-catenin pathway proteins in end-stage renal disease (ESRD) is limited.Aim of the study. To delineate the association of ESRD and Wnt-proteins including the agonistR-spondin 1, the transducer β-catenin and the antagonists Dickkopf-related protein 1 (DKK1) and sclerostin.Methods. Serum Wnt-pathway proteins levels were measured by ELISA, while other biochemicals were measured spectrophotometrically in 60 ESRD patients and 30 normal controls.Results. DKK1 and sclerostin were significantly higher in ESRD than in controls, and β-catenin and the catenin + R-Sponin-1 / DKK1 + sclerostin ratio, reflecting the ratio of agonist and transducer / antagonists (AT/ANTA), were significantly lower in ESRD. Logistic regression analysis showed that ESRD was significantly predicted by increased levels of DDK1 and sclerostin and lowered β-catenin (p<0.001). eGFR was significantly associated with DKK1 and sclerostin (inversely), β-catenin (positively) and the AT/ANTA ratio (r=0.468, p<0.001). DKK1 levels were significantly and positively correlated with urea, creatinine, and copper. DKK1 and sclerostin were inversely associated with hemoglobin and packet cell volume. Catenin was significantly negatively associated with copper, urea and creatinine.Conclusion. Wnt/β-catenin pathway proteins show significant alterations in ESRD, indicating significantly increased levels of antagonists and, therefore, attenuated Wnt/β-catenin pathway activity. The latter is associated with lowered eGFR and increased serum copper levels. Wnt/β-catenin pathway proteins are possible drug targets to treat ESRD or its consequences.
An analogy to understand the conceptual foundations of electromagnetics at the micro level from the perspective of mechanics
Authors: Fan Wei 
Published: February 2021

Abstract
This article attempts to provide a new analogy understanding of some conceptual foundations of electromagnetics from the perspective of mechanics to satisfy childhood curiosity. Among them, from the perspective of mechanics, charge can be understood as a form of electron momentum; electric current can be understood as a momentum flow; resistance can be understood as a momentum resistance of electrons; voltage can be interpreted as the potential pressure or energy level difference of the electron orbital potential; the electric field can be understood as a manifestation of the magnetic field of the current element.
A procedure for stable electrical measurements on a rock sample against high contact resistance as a prerequisite for electrical tomography
Authors: Suzuki Takeshi , Yoshimura Ryokei , Yamazaki Ken'ichi , Oshiman Naoto 
Published: February 2021

Abstract
As a basis for the electrical tomography of laboratory-scale rock samples (~ 10 cm), we developed a procedure for stable, multi-point, electrical measurement on rock samples that is effective even at high contact and sample resistance. Electrodes were strongly attached to the surface of high-resistivity rock using conductive and adhesive epoxy. Sustained current injection for long periods into high-resistance rocks was fulfilled using a constant direct current source with high internal resistance. Accurate voltage measurement across the high-resistance rock was accomplished by differential measurement using two high input resistance voltmeters. Measurements of high resistance also require a stable measurement environment: the temperature and humidity in the laboratory were controlled using an air conditioner, a humidifier, a dehumidifier, and a vinyl tent. Signal noise arising from human activities was eliminated by the remote operation of the measuring equipment and switching terminal. The proposed measurement procedure was evaluated in terms of the stability and accuracy of measured values and its applicability to electrical tomography. To assess measurement stability, we performed multiple measurements of a dry granite sample at various levels of absolute humidity. Our procedure recorded highly reproducible measurements under each humidity condition. The observed changes in measured values with absolute humidity indicate the importance of stabilising the temperature and humidity conditions in the laboratory. Applying our technique to multiple plastic samples with known resistivity confirmed its accuracy. To evaluate its applicability to electrical tomography, we measured the potential distribution on a dry granite surface in response to an injected current using a simple 40-electrode array. The potential distribution measured by our procedure agreed well with that predicted by forward modelling, demonstrating the robustness of our procedure in array measurements, and thus indicating its potential applicability to tomographic measurements for a variety of targets even under severe conditions including the relative dryness of ambient humidity.