bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on Inventory Path Optimization of VMI Large Logistics Enterprises Based on Ant Colony Algorithm
Authors: Wang Yaoyan 
Published: April 2021

Abstract
Based on the idea of vendor management (VMI) inventory, this paper focuses on the integration and optimization of transportation and inventory control in large-scale logistics system, so as to minimize the total cost of the logistics system. Aiming at the inventory path optimization of VMI large logistics enterprises, based on ant colony algorithm, an improved ant colony algorithm, namely ant colony system algorithm, is designed to solve the model. The algorithm model combines deterministic selection and random selection to obtain a comprehensive probability, and combines local and global pheromone updating. In this paper, we study a two-level supply chain system with multiple customers from one supplier and inventory routing problem. According to the characteristics of inventory routing problem, a single cycle inventory path optimization model with time window constraint based on stochastic demand is established. The goal is to minimize the total system cost, including inventory cost of downstream customers, system transportation cost and penalty cost for not meeting the time window. According to the characteristics of the model, the ant colony algorithm is selected as the optimization method, and the improved ant colony algorithm is designed to solve the example, and the feasibility of the algorithm and model is verified.
Speckle-Tracking Echocardiography is Preferable Measurement for Detecting the Early and Subtle Alterations of Cardiac Dysfunction in Diabetic Rats
Authors: Chen Zhiyan , Qi Yanchao , Wang Lijie , Ma Meifang , Li Na , Liu Zhe , Liu Suyun , Xue Lixiang , Guo Bingyan , Li Yongjun 
Published: April 2021

Abstract
BackgroundMyocardial damage caused by diabetic cardiomyopathy results in cardiac structural and functional abnormalities. Our previous studies have demonstrated that inhibiting RhoA/ROCK signaling pathway improved the structural abnormalities. The early detection of cardiac functional alterations accompanied by structural changes during therapy may facilitate better understanding on the pathophysiologic progress and guiding diabetic cardiomyopathy treatment. This study aimed to identify the optimal diagnostic measures for the early and subtle alterations of cardiac dysfunction in Type 2 diabetes mellitus rats.MethodsTwenty-four male Wistar rats were randomly divided into four groups and treated for 4 weeks: CON (control rats), DM (diabetic rats), DMF (DM + fasudil 10mg/kg/d) and CONF (CON + fasudil 10mg/kg/d). Left ventricular (LV) structure was quantified by histological staining and transmission electron microscopy. LV function and myocardial deformation were performed by high-frequency echocardiography.ResultsMyocardial hypertrophy and fibrosis were increased in diabetic rats and were remarkably alleviated in the DMF group. The diabetic rats had impaired LV performance evidenced by significant reduction of EF, FS and MV E/A, 26%, 34% and 20% respectively, while ROCK inhibition failed to improve the conventional ultrasonic parameters. However, the cardiac time intervals (CTI) parameters and speckle-tracking echocardiography (STE) parameters were significantly improved in the DMF group compared with the DM group (isovolumic contraction time, IVCT: P = 0.029; myocardial performance index, MPI: P = 0.037; fractional area change, FAC: P < 0.001; global circumferential strain, GCS: P = 0.003; global circumferential strain rate, GCSR: P = 0.021). Combining ROC curves with linear regression analysis, STE parameters were characterized by both the optimal predictions for cardiac damage [AUC (95% CI): FAC, 0.927 (0.744 to 0.993); GCS, 0.819 (0.610 to 0.945); GCSR, 0.899 (0.707 to 0.984)] and the strong correlations with cardiac fibrosis (FAC, r = -0.825; GCS, r = 0.772; GCSR, r = 0.829).ConclusionThe results suggest that STE strain and strain rate are preferable indicators of the early detection of subtle alterations in cardiac dysfunction and the quantitation of therapeutic efficacy in diabetic cardiomyopathy.
(Protocol) Preferred Reporting Items for Resistance Exercise Studies (PRIRES): An Umbrella Review of Systematic Reviews, Guidelines, and Position Stands for Item Extraction
Authors: Lin Ting-Yu , Chueh Ting-Yu , Hung Tsung-Min 
Published: April 2021

Abstract
BackgroundThe issues of replication and scientific transparency have been raised in exercise and sports science research. A potential means to address the replication crisis and enhance research reliability is to improve reporting quality and transparency. This study aims to formulate a reporting checklist as a supplement to the existing reporting guidelines, specifically for resistance exercise studies.MethodsSystematic reviews/meta-analyses, guidelines, and position stands related to resistance exercise since inception will be searched in PubMed and Scopus. Only studies published in English will be included. Two authors will independently screen titles/abstracts and then full-text articles against the inclusion criteria. Basic data will be extracted by the same two authors independently. The same two authors will independently extract items from systematic reviews, guidelines, and position stands that could potentially influence training efficiency, physiological/psychological functions, other health-related variables, or replication. Summaries of the findings and items extracted from the included systematic reviews/meta-analyses and included position stands or guidelines will be presented as tables. Using items adapted from the existing checklist Consensus on Exercise Reporting Template (CERT), a preferred reporting checklist for resistance exercise studies will be formulated. The protocol for this study was developed according to the reporting checklist for umbrella reviews published by Onishi and Furukawa in 2016.DiscussionThe proposed study is expected to build a reporting checklist with a high level of evidence, which can improve the reporting quality of future resistance exercise studies.Ethics and disseminationApproval from a human/animal research ethics committee is not required. The findings of the proposed study will be disseminated through conference presentations, our lab’s website in plain language, and, if possible, letters to the editor in peer-reviewed journals related to sport and exercise science.RegistrationThis study is registered with the EQUATOR Network under the title “Preferred Reporting Items for Resistance Exercise Studies (PRIRES).” PROSPERO registration number: CRD42021235259.
Origins of Chiral Life in Interstellar Molecular Clouds
Authors: Valkovic Vlado , Obhodas Jasmina 
Published: April 2021

Abstract
The phenomenon of life is discussed within a framework of its origin as defined by the following assumptions. Life, as we know it, is (H-C-N-O) based and relies on the number of bulk (Na-Mg-P-S-Cl-K-Ca) and trace elements (Li-B-F-Si-V-Cr-Mn-Fe-Co-Ni-Cu-Zn-As-Se-Mo-I-W). It originated when the element abundance curve of the living matter and of the universe coincided. By studying the chemical evolution of the solar neighborhood we have obtained the best agreement between the two curves for (4 ± 1)x109 years after the Big Bang. The dust-forming planetary system and stars already contained an excess of L- type amino acids and D- type sugars when incorporated into proteins and primitive organisms. Therefore, the emerging life had to be chiral. Because of the universe's aging, life originated only once.
Personalized tourniquet pressure may be a better choice than uniform tourniquet pressure during total knee arthroplasty: a meta-analysis of randomized- controlled trials.
Authors: Sun Changjiao , Yang Xin , Ma Qi , Yu Peng , Cai Xu , Zhou Yonggang 
Published: April 2021

Abstract
Background: Pneumatic tourniquets are widely used in total knee arthroplasty (TKA). Some surgeons prefer a uniform tourniquet inflation pressure (UTIP)for all patients; others use personalized tourniquet inflation pressures (PTIP) based on systolic blood pressure (SBP) and limb occlusion pressure(LOP). However, no consensus exists regarding the optimal mode of inflation pressure during TKA. This review aimed to appraise if personalized tourniquet inflation pressures are better than uniform tourniquet inflation. Methods: The databases (Web of Science，Embase，PubMed，Cochrane Controlled Trials Register,、Cochrane Library、Highwire、CBM、CNKI、VIP、Wanfang) were searched on March 2021 to systematically identify and screen the literature for randomized controlled trials (RCTs) involving PTIP and UTIP during total knee arthroplasty.Results: Thirteen randomized controlled trials, involving 1204 TKAs (1201 patients) were included in the systematic review. The meta-analysis identified a trend toward less Visual Analogue Scale (VAS) score at rest with PTIP group at one day（P=0.002），2-3day（P=0.01）, and less VAS score at activity 1day (P＜0.0001 ),2-3 days after the operation (P＜0.00001 )and discharge (P＜0.0001). No significant difference was found between the groups in terms of VAS score at rest when discharge (P=1.0). We also found no significant difference in terms of intraoperative blood loss（P=0.48）, total blood loss（P=0.15）, lower limb vein thrombosis （P=0.42）and thigh bullae（P=0.17）. However, in the PTIP group, we found a significant higher Hospital for Special Surgery (HSS) score （P=0.007）,broader knee Range of motion(ROM)（P=0.02）,less rate of thigh ecchymosis（P=0.00001）and shorter thigh circumference at one day(P=0.006), 2-3day (P=0.0005), and discharge(P=0.02).Conclusion: PTIP provides a similar bloodless surgical field compared with the conventional UTIP. Furthermore, PTIP provides less pain intensity, thigh circumference, rate of thigh ecchymosis, higher HSS and better initial recovery of knee flexion in total knee arthroplasty. Therefore, we recommend using a PTIP method during TKA. More adequately powered and better-designed randomized controlled trials （RCTs）studies with long-term follow-up are required to produce evidence-based guidelines regarding the PTIP method.
Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) Are Potentially Valuable Tests for Diagnosing Periprosthetic Joint Infection
Authors: Wu Hao , Pan Liping , Meng Zhichao , Liu Heng , Yang Xin , Cao Yongping 
Published: April 2021

Abstract
Background

Diagnosis of periprosthetic joint infection (PJI) is challenging for clinicians, and the most commonly used methods are too complicated and expensive for many clinical practices. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and platelet–to-mean platelet volume ratio (PVR), are simple biomarkers of infection and can be easily determined from routine blood tests. The aim of our study is to determine the value of these three parameters for the diagnosis of PJI.
Methods

One hundred and sixty-four patients who received revision surgery after total knee or total hip replacements were enrolled, 47 in a PJI group and 117 in an aseptic failure group. Receiver operator characteristic (ROC) analysis was used to compare the performance of NLR, PLR, PVR, C reactive protein (CRP), and erythrocyte sedimentation rate (ESR) for the diagnosis of PJI.
Results

The levels of NLR, PLR, and PVR were significantly higher in patients with PJI (all P < 0.05). ROC analysis showed that the area under curve (AUC) values of NLR (0.740), PLR (0.721), and PVR (0.668) were lower than those for CRP (0.896) and ESR (0.829). PLR had the highest sensitivity (85.11%) among all tested biomarkers, and NLR improved the diagnostic performance when used with CRP.
Conclusion

NLR and PLR are potentially valuable tests for the diagnosis of PJI, but PVR only has limited diagnostic value.
Spatial-Temporal Rainfall Models Based On Poisson Cluster Processes
Authors: Aryal Nanda R , Jones Owen D 
Published: April 2021

Abstract
We fit stochastic spatial-temporal models to high-resolution rainfall radar data using Approximate Bayesian Computation (ABC). As a baseline we fit a model of Cox, Isham and Northrop, which we then generalise in a variety of ways. Of central importance is the use of ABC, as it is not possible to fit models of this complexity using previous approaches. We also introduce the use of Simulated Method of Moments (SMM) to initialise the ABC fit.
Identification of potential key genes in anaplastic thyroid cancer using bioinformatics analysis
Authors: Li Zhenzhen , Chaoliang Xiong , Wei Jin , Chen Ping , Zhang Yanping , Zhu Huange , Zhao Yuqi , Lu Wei , He Qian , Geng Yan , Zhu Jianhong 
Published: April 2021

Abstract
Background

Anaplastic thyroid cancer (ATC) has a high degree of malignancy and a poor prognosis. Its incidence accounts for approximately 10–15% of all thyroid cancers. The purpose of this study was to determine the differentially expressed genes (DEGs) of ATC through biometric analysis technology, clarify the potential interactions between them, and screen genes related to the prognosis of ATC.
Methods

The GSE29265, GSE65144, GSE33630, and GSE85457 expression profiles downloaded from the Gene Expression Omnibus database (GEO) contained a total of 117 tissue samples (81 normal thyroid tissue samples and 36 ATC samples). The four datasets were integrated and analyzed by the limma packages to obtain DEGs. With these DEGs, we performed gene ontology functional annotation and Kyoto Encyclopedia of Genes and Genomes pathway analyses using the Database for Annotation, Visualization and Integrated Discovery, protein-protein interaction (PPI) analysis using Cytoscape, and survival analysis using the Kaplan-Meier (KM) plotter.
Results.

After R integration analysis of the four datasets, 764 DEGs were obtained, i.e., 314 upregulated and 450 downregulated genes. Among the hub DEGs obtained in the PPI network, the expression levels of thymidylate synthase (TYMS), fibronectin 1, chordin-like 1, syndecan 2, integrin alpha 2, collagen type I alpha 1 chain, collagen type IX alpha 3 chain (COL9A3), and collagen type XXIII alpha 1 chain (COL23A1) were associated with ATC prognosis. These results showed that the overall survival and recurrence-free survival of TYMS, COL9A3, and COL23A1 were statistically significant in our KM plotter survival analysis; thus, these DEGs may be used as potential biomarkers of ATC.
Conclusion

This study identified several potential target genes and pathways that may affect the development of ATC. These findings provide new insights for the detection of novel diagnostic and therapeutic biomarkers for ATC.
Value of Maximum Standard Uptake Value as a Positron Emission Tomography/Computed Tomography Index in the Diagnosis and Prognosis of Patients with Gastric Cancer
Authors: Wang Kairui , Wang Baozhen , Zhao Qian , Guo Li , Liang Yongfeng , Zhao Duowen , Chen Jing , Li Tao 
Published: April 2021

Abstract
Background: To study the application value of standard uptake value (SUVmax), a positron emission tomography/computed tomography (PET/CT) index in the diagnosis and evaluation of the prognosis of patients with gastric cancer who have not received any treatment. Methods: A retrospective analysis was made on the patients who were diagnosed to have gastric cancer at the General Hospital of Ningxia Medical University and received a PET/CT examination prior to treatment. According to different factors like sex, pathological stage, and survival time, the SUVmax in the results of 18F-labelled fluoro-2-deoxyglucose (18F-FDG) PET/CT examination was statistically compared and analysed. Results: A total of 110 newly diagnosed patients with gastric cancer were included in this study. Pathological results confirmed that there were 78 cases of gastric adenocarcinoma, 30 cases of primary gastric lymphoma and two cases of chronic atrophic gastritis. The difference between the primary gastric lymphoma group and gastric adenocarcinoma groups was statistically significant (t = 4.13, P < 0.05). In the postoperative pathological report of patients with gastric cancer, the SUVmax of stage I, stage II, stage III and stage IV were 2.89 ± 1.36, 14.09 ± 9.32, 7.36 ± 3.72, and 10.20 ± 1.91, respectively, the difference between each group was statistically significant (F = 16.10, P < 0.05).The univariate survival analysis showed that there was a significant difference in survival time between the low SUVmax and high SUVmax groups (X2 = 5.08, P < 0.05). Cox multivariate survival analysis showed that SUVmax was an independent factor affecting postoperative survival time of patients with gastric adenocarcinoma (P < 0.05). Compared with the low SUVmax group, patients in the high SUVmax group had a higher postoperative death risk than those in the low SUVmax group, hazard ration (HR) = 3.91 (95% confidence interval [CI]: 1.09-14.01). Conclusion: The index of SUVmax in PET/CT can provide a reliable semi-quantitative diagnostic value for pathological staging after gastric cancer surgery. Furthermore, SUVmax has an important reference value for the survival time of patients after gastric cancer surgery, which can better guide clinical treatment.
Propranolol Inhibits the Proliferation of Human Glioblastoma Cell Lines Through Notch1 and Hes1 Signaling System
Authors: Kim Hyun Sik , Park Young Han , Kwon Mi Jung , Song Joon Ho , Chang In Bok 
Published: April 2021

Abstract
PurposeThe anti-tumor effect of the beta-adrenergic receptor antagonist propranolol in breast cancer is well known; however, its activity in glioblastoma is not well-evaluated. The Notch-Hes pathway is known to regulate cell differentiation, proliferation, and apoptosis. We investigated the effect of propranolol to human glioblastoma cell lines, and the role of Notch and Hes signaling in this process.MethodsWe performed immunohistochemical staining on 31 surgically resected primary human glioblastoma tissues. We also used glioblastoma cell lines of U87-MG, LN229, and neuroblastoma cell line of SH-SY5Y in this study. The effect of propranolol and isoproterenol on cell proliferation was evaluated using the MTT assay (absorbance 570nm). The impact of propranolol on gene expression (Notch and Hes) was evaluated using real-time (RT) PCR, whereas protein levels of Notch1 and Hes1 were measured using western blotting (WB), simultaneously. Small interfering RNA (siRNA) was used to suppress the Notch gene to investigate its role in the proliferation of glioblastoma.ResultsPropranolol and isoproterenol caused a dose-dependent decrease in cell proliferation (MTT assay). RT-PCR showed an increase in Notch1 and Hes1 expression by propranolol, whereas WB demonstrated increase in Notch1 protein, but a decrease in Hes1 by propranolol. The proliferation of U87-MG and LN229 was not significantly suppressed after transfection with Notch siRNA.ConclusionThese results demonstrated that propranolol suppressed the proliferation of glioblastoma cell lines and neuroblastoma cell line, and Hes1 was more closely involved than Notch1 was in glioblastoma proliferation.
Association Between Gestational Weight Gain in Women With Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes: a Retrospective Cohort Study
Authors: Shi Ping , Liu Aimin , Yin Xiaoyan 
Published: April 2021

Abstract
Purpose: To examine the association between gestational weight gain (GWG) in women with gestational diabetes mellitus (GDM) and adverse pregnancy outcomes (APOs).Methods: This retrospective cohort study enrolled women with GDM and singleton live birth pregnancies who delivered between January 2010 and December 2020. Univariable and multivariable logistic regression analyses were used to determine the association between GWG outside the Institute of Medicine (IOM) guidelines and APOs.Results: Overall, 1606 women with GDM fulfilled the inclusion criteria. After adjusting for confounders, total GWG above IOM guidelines in pregnancy was associated with an increased risk of caesarean delivery [adjusted odds ratio (aOR)=1.34, 95% confidence interval (CI): 1.04-1.72], hypertensive disorders of pregnancy (HDP) (aOR=2.00, 95% CI: 1.28-3.12), preeclampsia (aOR=2.06, 95% CI: 1.01-3.12), macrosomia (aOR=1.55, 95% CI: 1.13-2.13) and LGA (aOR=1.83, 95% CI: 1.43-2.10), and a decreased risk of premature rupture of membrane (PROM) (aOR=0.46, 95% CI: 0.36-0.60) and preterm birth (aOR=0.35, 95% CI: 0.26-0.44); total GWG below IOM guidelines in pregnancy was associated with an increased relative risk of preterm birth (aOR=1.96, 95% CI: 1.44-2.66) and SGA (aOR=1.32, 95% CI: 1.11-1.50) and a decreased relative risk of macrosomia (aOR=0.35, 95% CI: 0.23-0.53). Further, in both second and third trimesters of pregnancy, GWG above IOM guidelines was found to be associated with a high risk of HDP (aOR=2.55, 95% CI: 1.86-3.38; aOR=1.93, 95% CI: 1.08-2.98), preeclampsia (aOR=2.28, 95% CI: 1.21-3.81; aOR=2.17, 95% CI: 1.35-4.37), macrosomia (aOR=1.20, 95% CI: 1.02-1.82; aOR=2.02, 95% CI: 1.51-2.64) and LGA (aOR=1.65, 95% CI: 1.36-2.04; aOR=1.88, 95% CI: 1.62-2.18). GWG above IOM guidelines in the third trimester of pregnancy also increased the risk of caesarean delivery (aOR=1.48, 95% CI: 1.16-2.34). While GWG below IOM guidelines in both second and third trimesters of pregnancy was associated with a decreased relative risk of macrosomia (aOR=0.66, 95% CI: 0.52-0.78; aOR=0.52, 95% CI: 0.39-0.63). In addition, GWG below IOM guidelines in the third trimester of pregnancy was associated with an increased relative risk of preterm birth (aOR=1.52, 95% CI: 1.12-2.05) and SGA (aOR=1.21, 95% CI: 1.10-1.69).Conclusion: GWG, outside the IOM guidelines has increased risks of APOs among women with GDM, implying that careful surveillance for GWG during different stages of pregnancy is warranted.
Robust valley polarized states beyond topology
Authors: Bisharat Dia'aaldin J. , Sievenpiper Daniel F. 
Published: April 2021

Abstract
Valley-contrast physics has gained considerable attention, particularly for realizing photonic topological insulators (PTIs) that support reflection-free valley-polarized edge modes (VPEMs) in the absence of inter-valley scattering. It is an open question whether similar robust states can exist in the absence of topological order. We propose a new approach to VPEMs based on a line defect in a topologically-trivial, C6υ-symmetric photonic crystal (PhC). The VPEMs result from opposing orbital angular momenta (OAM) due to a local valley Hall effect (LVHE), where the valley polarization is locally defined as opposed to being fixed throughout the bulk of the PhC. We fabricate our device on a silicon-on-insulator (SOI) slab and characterize it at near-infrared frequencies showing robust transmission through sharp bends. Our results present a new perspective to the existence of gapless chiral edge (kink) states and outlines a new waveguiding mechanism applicable to the electromagnetic spectrum as well as other wave systems including plasmonics, mechanics and acoustics.