bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Model to Predict the Probability for Intraoperative Blood Transfusion During Lumbar Spinal Stenosis and Femoral Fracture Surgeries in Aged patients
Authors: Nie Zhiyang , Ma Wanru , Hu Junhua 
Published: March 2021

Abstract
Background: Lumbar spinal stenosis and femoral fracture are common orthopedic problems in aged patients, and the probability of transfusion of red blood cell products during surgery is relatively high. The goal of this study was to predict the probability of transfusion of allogeneic red blood cells and the volume of blood consumption based on the clinical characteristics of patients before surgery.Methods: The medical records of 565 patients over 65 years old who underwent posterior lumbar surgery for lumbar spinal stenosis and those of 586 patients over 65 years old receiving surgery for femoral fracture were reviewed. The clinical characteristics of the patients were subjected to multivariate regression analysis. The influence of these characteristics based on the odds ratio of each multivariate risk factor was assessed to predict the probability of intraoperative red blood cell transfusion. Non-linear regression was performed to predict the probability of intraoperative blood transfusion and the volume of blood used for patients with different scores.Results: The factors that significantly influenced blood use during lumbar spinal stenosis surgery in aged patients(P<0.05) included age>75 years old, body mass index (BMI)>24, abnormal coagulation function, preoperative hemoglobin (Hb)≤110 g/L, multisegmental lesions of the lumbar spine and secondary lumbar surgery. The factors that significantly influenced blood use during femoral fracture surgery in aged patients (P<0.05) included age>75 years old, BMI<19, abnormal coagulation function, preoperative Hb≤110g/L, administration of antiplatelet drugs (e.g., aspirin, clopidogrel), femoral shaft fracture, and the time from fracture to surgery exceeding 48 h. These factors were introduced into a multiple logistic regression model, and weighted scoring was performed according to their relative risk to establish a risk scoring system to predict the probability. More than 50% of patients receiving an intraoperative red blood cell transfusion during surgery for lumbar spinal stenosis or femoral fracture scored＞1.Conclusion: The probability of transfusion of allogeneic red blood cells and the blood volume needed can be predicted preoperatively in aged patients undergoing lumbar spinal stenosis and femoral fracture surgeries. This can reduce the need for blood matching during surgery, allow adjustment of the blood inventory, and ensure safety.
Genomic Data Reveal the Genetic Variation among Natural Mangifera Casturi Kosterm. Hybrids, an Underutilized Fruit Tree Under ‘Extinct in Wild’ Status from Kalimantan Selatan, Indonesia
Authors: Matra Deden Derajat , Fathoni Muh Agust Nur , Majiidu Muhamad , Wicaksono Hanif , Sriy Agung , Gunawan - , Susanti Hilda , Fitmawati - , Sari Rismita , Siregar Iskandar Zulkarnaen , Poerwanto Roedhy 
Published: March 2021

Abstract
Background: Mangifera casturi Kosterm. is an endemic local mango fruit from Kalimantan Selatan, Indonesia. The limited genetic information available on this fruit has severely limited the scope of research into its genetic variation and phylogeny. This study aimed to collect genomic information from M. casturi using next-generation sequencing technology and to develop microsatellite markers and perform Sanger sequencing for DNA barcoding analysis.Results: The clean reads of the Kasturi accession of M. casturi were assembled de novo using a Ray assembler, producing 259,872 scaffolds with an N50 value of 1,445 bp. Fourteen polymorphic microsatellite markers were developed from 11,040 sequences containing microsatellite motifs. In total, 55 alleles were produced, and the mean number of alleles per locus was 3.93. Results from the microsatellite marker analysis revealed broad genetic variation in M. casturi. Phylogenetic analysis was performed using internal transcribed spacers (ITS), matK, rbcL, and trnH-psbA. The phylogenetic tree of chloroplast markers showed that Kasturi, Mawar, Pelipisan, Pinari, and Hambawang belong to one group, with M. indica as the female ancestor. In comparison, the phylogenetic tree of ITS markers indicated several Mangifera species as multiple ancestors of M. casturi. Conclusions: This study strongly suggested that M. casturi originated from the cross-hybridization of multiple ancestors. Further, crossing the F1 hybrids of M. indica and M. quadrifida with other Mangifera spp. was hypothesized to produce the observed high genetic variation. The genetic information for this fruit is also a resource for the breeding and improvement as well as for conservation studies of this species.
Curing Kinetics, Mechanical Properties and Thermomechanical Analysis of Carbon Fiber/epoxy Resin Laminates with Different Ply Orientations
Authors: Zhang Chenglin , Gu Guohua , Dong Shuhua , Lin Zhitao , Wei Chuncheng , Tan Hongsheng 
Published: March 2021

Abstract
In this study, the nonisothermal differential scanning calorimetry (DSC) was carried out to evaluate the curing reaction of fiber/epoxy laminates. The optimal curing process of the prepreg was obtained by T-β extrapolation method and nth-order reaction curing kinetic equation. The bending strength, impact strength and thermodynamic properties of the composite laminates with different ply orientations were investigated, respectively. The results show that the apparent activation energy and the reaction order of the prepregs are 82.89 kJ/mol and 0.92, respectively. The curing process of carbon fiber/epoxy resin prepreg is 130 ℃ /60min + 160 ℃/30 min. The bending strength of [0]10 laminate is 1948.3 MPa, which is 11.8 times higher than that of [+ 45/-45]5s laminate, and 96.4% higher than that of [0/90]5s laminate. The impact strength of [0]10 laminate is higher than that of [+ 45/-45]5s and [0/90]5s laminates. The glass transition temperature (Tg) of the laminates is 142 ~ 146 ℃, and the loss factor of [0]10 laminate is significantly higher than that of [+ 45/-45]5s and [0/90]5s laminates. This research provides a theoretical basis for the further application of prepregs to fiber composite materials.
Event-triggered Optimal Control for Nonlinear Stochastic Systems via Adaptive Dynamic Programming
Authors: Zhang Guoping , Zhu Quanxin 
Published: March 2021

Abstract
For nonlinear Itˆo-type stochastic systems, the problem of event-triggered optimal control (ETOC) is studied in this paper, and the adaptive dynamic programming (ADP) approach is explored to implement it. The value function of the Hamilton-Jacobi Bellman(HJB) equation is approximated by applying critical neural network (CNN). Moreover, a new event-triggering scheme is proposed, which can be used to design ETOC directly via the solution of HJB equation. By utilizing the Lyapunov direct method, it can be proved that the ETOC based on ADP approach can ensure that the CNN weight errors and states of system are semiglobally uniformly ultimately bounded (SGUUB) in probability. Furthermore, an upper bound is given on predetermined cost function. Speciﬁcally, there has been no published literature on the ETOC for nonlinear Itˆo-type stochastic systems via the ADP method. This work is the ﬁrst attempt to ﬁll the gap in this subject. Finally, the eﬀectiveness of the proposed method are illustrated through two numerical examples.
Influence of Dietary Habits on Depression Among Patients With Rheumatoid Arthritis: A Cross-Sectional Study Using KURAMA&nbsp;Cohort Database
Authors: Minamino Hiroto , Katsushima Masao , Hashimoto Motomu , Fujita Yoshihito , Torii Mie , Ikeda Kaori , Isomura Nozomi , Oguri Yasuo , Yamamoto Wataru , Watanabe Ryu , Murakami Kosaku , Murata Koichi , Nishitani Kohei , Tanaka Masao , Ito Hiromu , Uda Miyabi , Nin Kazuko , Arai Hidenori , Matsuda Shuichi , Morinobu Akio , Inagaki Nobuya 
Published: March 2021

Abstract
BackgroundAlthough depression is one of the most common comorbidities of rheumatoid arthritis (RA) and is known as a critical influence on RA remission rates, there is little knowledge regarding a possible therapeutic strategy for depression in a RA population. Most recently, clinical evidence of dietary improvement for depression has emerged in a general population, but the relationship between dietary habits and depression has not been investigated in RA. The purpose of this study is to elucidate clinical associations between depression, dietary habits and disease activity/physical function in patients with RA.MethodsA cross-sectional study was performed with 267 female outpatients from the KURAMA database. Using the Hospital Anxiety and Depression Scale (HADS), we classified the participants into three groups by depression state, and their characteristics were compared. Using the 20-items on the self-reported food frequency questionnaire, we investigated the relationship between dietary habits and depression or anxiety, adopting a trend test and a multivariate standardized linear regression analysis for the HADS score as a dependent variable.ResultsClassification of the depressive state revealed that current disease activity and physical dysfunction (28-Joint RA Disease Activity Score-C-reactive protein (DAS28-CRP) as well as the health assessment questionnaire disability Index (HAQ)) were significantly increased according to the stage of depression. Trend analysis identified three of 20 foods, i.e., fish, vegetables and fruit, the consumption of which was inversely associated with the depression score. Furthermore, multiple linear regression analysis revealed that the depression score was negatively associated with frequent fish intake (> 3 times per week) (Estimate -0.53, p = 0.033) as well as remission of HAQ (Estimate -0.88, p ≤ 0.001). For the anxiety score, none of the dietary habits showed any correlation in the multiple regression analysis.ConclusionDepression state assessed by HADS score was significantly and independently associated with both fish intake frequency and remission of physical dysfunction in an RA population. Modification of dietary habits, such as that by increased fish consumption, may have a beneficial effect on the depression state in RA patients.
Safety, Pharmacokinetics, and Preliminary Activity of CDK4/6 Inhibitor FCN-437c in Chinese Female Patients with HR+HER2- Advanced Breast Cancer (ABC) From Phase Ia Study
Authors: Zhang Jian , Wang Xiaojia , Wang Xian , Hui Aimin , Wu Zhuli , Tian Ling , Xu Changjiang , Yang Yuchen , Zhang Wenjing , Hu Xichun 
Published: March 2021

Abstract
Purpose: This is a phase Ia, first-in-human study aiming to assess the safety, maximum tolerated dose (MTD), pharmacokinetic (PK) and anti-tumor activity of FCN-437c, CDK4/6 inhibitor, as monotherapy in patients with HR+HER2- ABC (advanced breast cancer) who failed standard of care. Methods: Regular 3+3 dose escalation design was utilized with starting dose of 50 mg per day for 3 weeks on -1 week off treatment in a 28-day cycle. Seventeen eligible female patients with HR+HER2- ABC were enrolled at different dose levels: 50 mg (n = 3), 100 mg (n = 3), 200 mg (n = 3), 300 mg (n = 6) and 450 mg (n = 2). Results: Two patients in the 450 mg dose group experienced DLT of grade 4 thrombocytopenia and neutropenia respectively, and no DLT was observed in other dose levels. The most frequently reported TEAEs was hematological, including leukopenia (94.1%), neutropenia (88.2%), anemia (64.7%) and thrombocytopenia (47.1%). Major grade 3-4 TEAEs were neutropenia and leukopenia, occurring in 11 (64.7%) and 8 (47.1%) patients, respectively. The exposure increased almost in proportion to given dose ranging from 50 to 200 mg. At multiple dose levels from 200 to 450 mg, there appeared to be a trend of saturation. MTD was determined to be 300 mg. Of 15 measurable patients, nine (60.0%) had the best response of stable disease and no objective response was observed. Conclusions: FCN-437c has established an acceptable safety profile with no unexpected signals compared to other CDK4/6 inhibitors. (NCT04488107, Jul 13th 2020)
A Formation Mechanism and Tribological Properties of PTFE Transfer Film
Authors: Wang Hai , Qi Xiaowen , Dong Yu , Fan Bingli , Liu Changxin , Zhang Yan 
Published: March 2021

Abstract
Polytetrafluoroethylene (PTFE), as one of the most widely used solid lubricating materials, is thought to be very efficient at forming transfer film because of terrific low intermolecular force. This work investigates the tribological properties of PTFE transfer film under dry friction, and further explores its formation process and evolution mechanism. The friction coefficient is the lowest when the transfer film thickness is in range of 8-12 μm. An evaluation method for transfer film is proposed. The results show that the quality of the transfer film is closely related to the test load and velocity. This method is expected to be a general evaluation method for polymer transfer film, which can further directly evaluate the wear state of polymers, and even directly predict the tribological properties of polymers and abrasion life.
Changes in Patellar Morphology Following Soft Tissue Surgical Correction of Recurrent Patellar Dislocation in Children With Low-grade Trochlear Dysplasia
Authors: Dong Conglei , Wang Yanyang , Zhao Chao , Niu Jinghui , lin Wei , Chen Xiaobo , Xu Chenyue , Wei Maozheng , Wang Fei 
Published: March 2021

Abstract
Purpose: Studies indicated that patellofemoral joint dysplasia could be caused by patellar dislocation. The purpose of the study was to investigate the changes in patellar morphology following soft tissue surgical correction of recurrent patellar dislocation in children with low-grade trochlear dysplasia.Methods: The prospective study was performed between November 2007 and December 2012. Finally, 25 cases, with the mean age of 8.4 years (range from 7 to 10 years), were admitted to our study. All patients were diagnosed as bilateral recurrent patellar dislocation associated with femoral trochlear dysplasia. The knee that had suffered an injury or dislocated most frequently was treated with medial patellar retinacular plasty (Group S). The contralateral knee, which served as a control was treated conservatively (Group C). Axial CT scans were undertaken in all patients to assess the patellar morphological characteristics on a particular axial image which was established at the point with the greatest patellar width based on measurements preoperatively and at the final follow-up.Results: Preoperatively, there were no statistically significant differences between the patellar morphology in the two groups (P>0.05). Many radiological parameters of patellar morphology were significantly different between the two groups at the final follow-up, including well-known parameters, such as the mean patellar width (Group S, 40.58 mm (SD 1.26); Group C, 36.41 mm (SD 1.17); p < 0.001), the mean patellar thickness (Group S, 11.59 mm (SD 0.74); Group C, 9.38 mm (SD 0.56); p < 0.001) and the mean wiberg index (Group S, 0.54 (SD 0.06); Group C, 0.72 (SD 0.08); p < 0.001). Little known parameters such as the ratio of length of lateral patella to medial patella (Group S, 1.26 (SD 0.17); Group C, 1.69 (SD 0.21); p < 0.001), which is a measurement of facet asymmetry. However, the wiberg angle was not significantly different between the two groups (Group S, 128.63° (SD 9.05); Group C, 125.47° (SD 13.96); p > 0.05) at the final follow-up.Conclusions: The patellar morphology can be significantly improved by early (before epiphyseal closure) soft tissue surgical correction in children with patellar instability associated with low-grade femoral trochlear dysplasia (Dejour A and B).
Incidence and Survival Outcomes in Patients with Synchronous Lung Metastases Upon Initial Metastatic Breast Cancer Diagnosis in China
Authors: Lin Shaoyan , Mo Hongnan , Li Yiqun , Guan Xiuwen , Chen Yimeng , Wang Zijing , Yuan Peng , Wang Jiayu , Luo Yang , Fan Ying , Cai Ruigang , Li Qiao , Chen Shanshan , Zhang Pin , Li Qing , Ma Fei , Xu Bing-He 
Published: March 2021

Abstract
Background: The incidence and survival of breast cancer lung metastases (BCLM) patients at initial diagnosis of metastatic breast cancer (MBC) remain poorly identified in China.Methods: We attained clinical data of 3161 MBC patients initially diagnosed between December 1991 and September 2019 from the China National Cancer Center and finally included 2263 MBC patients in this study, among which 809 patients presented with lung metastases at first MBC diagnosis. The risk factors for BCLM were determined using multivariate logistic regression analysis and the prognostic factors of BCLM patients were assessed by univariate and multivariate Cox regression analyses.Results: Patients with triple-negative subtype (42.3%) harbored the highest incidence proportions of lung metastases. Age ≥ 50 years, ECOG 2 and triple-negative subtype were remarkably associated with higher incidence of lung metastases, while N3, liver and bone metastases were significantly correlated with lower odds of lung metastases at diagnosis. The median survival of BCLM patients was 41.7 months, with triple-negative subtype experiencing the worst prognosis of 26.8 months. ECOG 2, N3, HR-/HER2+ subtype, triple-negative subtype, liver metastases and bone metastases were significantly correlated with poor survival of BCLM patients.Conclusions: Our study provides essential information on clinicopathological features, incidence and survival outcomes of BCLM patients at initial diagnosis of MBC in China.
Risk Factors of Unintended Return to the Operating Room in Adult Spinal Deformity
Authors: Chan Lung , Li Yue , Hai Yong , Liu Yuzeng , Zhang Yangpu 
Published: March 2021

Abstract
Background
To evaluate the incidence and risk factors associated with unintended return to the operating room in adult spinal deformity after spinal deformity corrective surgery.
Methods
Retrospect of 141 adult spinal deformity patients in a single institution between January 2017 to December 2019. Inclusion criteria enrolled 18 to 80 years old patients who diagnosed congenital/idiopathic/syndromic/acquired spinal deformity underwent posterior corrective spinal surgery. The surgical details and complications were recorded. The rate of unintended return to the operating room (UIROR) during hospitalization was examined, and the risk factors of unintended return to the operating room were investigated via multivariate analysis.
Results
This is a retrospective study. One hundred and forty-one patients underwent spinal deformity surgery with a mean age of 31.8 years (range 18–69 years) were studied. The rate of unintended return to the operating room was 10.64% (15/141). Two of 15 patients had twice unintended surgery during hospitalization (13.33%). The most principal complication was neurologic deficit (73.3%), Six of 15 postoperative present implants deviation causes severe lower limbs radiating pain (40%). The multivariate analysis shows higher apical vertebral rotation (AVR > grade Ⅱ, odds ratio [OR] = 9.534; 95% CI = 1.983–45.839; P = .005), obesity (OR = 11.776; 95% CI = 1.400-98.851; P = .023), and previous neurological symptom (OR = 7.748; 95% CI = 2.051–29.277; P = .003) were independent predictors of unintended return to the operating room.
Conclusion
Postoperative neurologic deficit and short-term implant malposition are essential causes of unintended return to the operating room in adult spinal deformity patients. Preoperative factors such as higher AVR (> Grade Ⅱ), obesity, and previous neurological symptom may significantly increase the risk of morbidity in UIROR. Spine surgeons should be alert to these risk factors and require adequate preoperative evaluations to reduce the incidence of unintended return to the operating room.
Adjuvant Chemoradiotherapy Versus Radical Surgery After Transanal Endoscopic Microsurgery for Intermediate Pathological Risk Early Rectal Cancer: a Single Center Experience With Long-term Surveillance
Authors: Li Yunhao , Qiu Xiaoyuan , Shi Weikun , Lin Guole 
Published: March 2021

Abstract
BackgroundThe choice of subsequent treatment for intermediate risk rectal tumors after Transanal endoscopic microsurgery (TEM) between adjuvant chemoradiotherapy and total mesorectal excision (TME) is controversial. The present study aimed to compare survival and functional outcome between these two strategies. Methods This retrospective study included intermediate risk early rectal cancer patients after TEM in our center between 2010 and 2017. Patients were divided into adjuvant treatment and TME groups. Intermediate risk was defined as pT1 with lymphovascular invasion, poor differentiation or large diameter (3-5 cm) or pT2 with small diameter(less than 3cm). The study was based on follow-up data on survival and results from distributed validated scales for functional outcome. ResultsPostoperative overall survival (OS) and disease-free survival (DFS) were comparable between groups (p = 0.619 and p = 0.712 respectively). Pathological T stage was an independent risk factor for DFS (HR 3.09, 95% CI 1.66 - 4.18, p = 0.044). Anorectal symptoms, such as buttock pain, was significantly prevalent in the TME group (p = 0.030). TME group presented with poorer bowel function, including stool urgency (p < 0.001), bowel frequency (p = 0.016), severity of LARS (p = 0.039) and total LARS score (p = 0.040). Except for a lower score of vaginal lubrication in TME group than the adjuvant treatment group, sexual function was similar between the groups. ConclusionLike TME, adjuvant chemoradiotherapy is an alternative option for intermediate risk early rectal cancer after TEM and is associated with similar survival outcomes and better bowel function.
Heterogeneity in spontaneous sleep arousals: positive and negative links with early amyloid-beta and cognition
Authors: Chylinski Daphne , Egroo Maxime Van , Narbutas Justinas , Koshmanova Ekaterina , Berthomier Christian , Berthomier Pierre , Brandewinder Marie , Salmon Eric , Bahri Mohamed , Bastin Christine , Collette Fabienne , Phillips Christophe , Maquet Pierre , Muto Vincenzo , Vandewalle Gilles 
Published: March 2021

Abstract
Recent literature is pointing towards a tight relationship between sleep quality and amyloid-beta (Aβ) accumulation, a hallmark of Alzheimer’s disease (AD). Sleep arousals are considered to induce sleep disruption, and though their heterogeneity has been suggested, their correlates remain to be established. We classified arousals in sleep of 100 healthy older individuals according to their association with muscular tone increase (E+/E-) and sleep stage transition (T+/T-), and show differences in EEG oscillatory compositions across arousal types. We found that T + E- arousals, which interrupt sleep stability, were positively correlated with Aβ burden in brain regions earliest affected by AD neuropathology. By contrast, more prevalent T-E + arousals, upholding sleep continuity, were associated with lower cortical Aβ burden, and better cognition. We provide empirical evidence that spontaneous arousals are diverse and differently associated with brain integrity and cognition. Sleep arousals may offer opportunities to transiently synchronise distant brain areas, akin to sleep spindles.