bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neutral signature gauged supergravity solutions
Authors: Gutowski J. , Sabra W. A. 
Published: February 2021

Abstract
We classify all supersymmetric solutions of minimal D = 4 gauged supergravity with (2) signature and a positive cosmological constant which admit exactly one Killing spinor. This classification produces a geometric structure which is more general than that found for previous classifications of N = 2 supersymmetric solutions of this theory. We illustrate how the N = 2 solutions which consist of a fibration over a 3-dimensional Lorentzian Gauduchon-Tod base space can be written in terms of this more generic geometric structure.
Black rings in large D membrane paradigm at the first order
Authors: Mandlik Mangesh 
Published: February 2021

Abstract
Black rings are the black objects found in D spacetime dimensional gravity when D ≥ 5. These have event horizon topology SD−3× S1. In this work the solutions of the large D membrane paradigm dual to stationary black rings in Einstein-Maxwell theory with or without cosmological constant are studied. It is shown that the first order membrane equations can only admit static asymptotically flat black rings, and the equilibrium angular velocity for the asymptotically AdS black rings at large D was obtained. The thermodynamic and dynamic stability of the asymptotically flat black ring solutions is studied. The apparent shortcomings of some of these results are argued to be curable within the large D membrane paradigm framework.
Extracellular vesicles as mediators and markers of acute organ injury: current concepts
Authors: Weber Birte , Franz Niklas , Marzi Ingo , Henrich Dirk , Leppik Liudmila 
Published: February 2021

AbstractDue to the continued high incidence and mortality rate worldwide, there is a need to develop new strategies for the quick, precise, and valuable recognition of presenting injury pattern in traumatized and poly-traumatized patients. Extracellular vesicles (EVs) have been shown to facilitate intercellular communication processes between cells in close proximity as well as distant cells in healthy and disease organisms. miRNAs and proteins transferred by EVs play biological roles in maintaining normal organ structure and function under physiological conditions. In pathological conditions, EVs change the miRNAs and protein cargo composition, mediating or suppressing the injury consequences. Therefore, incorporating EVs with their unique protein and miRNAs signature into the list of promising new biomarkers is a logical next step. In this review, we discuss the general characteristics and technical aspects of EVs isolation and characterization. We discuss results of recent in vitro, in vivo, and patients study describing the role of EVs in different inflammatory diseases and traumatic organ injuries. miRNAs and protein signature of EVs found in patients with acute organ injury are also debated.
The role of delta and theta oscillations during ego-motion in healthy adult volunteers
Authors: Ertl M. , Zu Eulenburg P. , Woller M. , Dieterich M. 
Published: February 2021

AbstractThe successful cortical processing of multisensory input typically requires the integration of data represented in different reference systems to perform many fundamental tasks, such as bipedal locomotion. Animal studies have provided insights into the integration processes performed by the neocortex and have identified region specific tuning curves for different reference frames during ego-motion. Yet, there remains almost no data on this topic in humans.In this study, an experiment originally performed in animal research with the aim to identify brain regions modulated by the position of the head and eyes relative to a translational ego-motion was adapted for humans. Subjects sitting on a motion platform were accelerated along a translational pathway with either eyes and head aligned or a 20° yaw-plane offset relative to the motion direction while EEG was recorded.Using a distributed source localization approach, it was found that activity in area PFm, a part of Brodmann area 40, was modulated by the congruency of translational motion direction, eye, and head position. In addition, an asymmetry between the hemispheres in the opercular-insular region was observed during the cortical processing of the vestibular input. A frequency specific analysis revealed that low-frequency oscillations in the delta- and theta-band are modulated by vestibular stimulation. Source-localization estimated that the observed low-frequency oscillations are generated by vestibular core-regions, such as the parieto-opercular region and frontal areas like the mid-orbital gyrus and the medial frontal gyrus.
Evaluation of protein secondary structure from FTIR spectra improved after partial deuteration
Authors: De Meutter Joëlle , Goormaghtigh Erik 
Published: February 2021

AbstractFTIR spectroscopy has become a major tool to determine protein secondary structure. One of the identified obstacle for reaching better predictions is the strong overlap of bands assigned to different secondary structures. Yet, while for instance disordered structures and α-helical structures absorb almost at the same wavenumber, the absorbance bands are differentially shifted upon deuteration, in part because exchange is much faster for disordered structures. We recorded the FTIR spectra of 85 proteins at different stages of hydrogen/deuterium exchange process using protein microarrays and infrared imaging for high throughput measurements. Several methods were used to relate spectral shape to secondary structure content. While in absolute terms, β-sheet is always better predicted than α-helix content, results consistently indicate an improvement of secondary structure predictions essentially for the α-helix and the category called “Others” (grouping random, turns, bends, etc.) after 15 min of exchange. On the contrary, the β-sheet fraction is better predicted in non-deuterated conditions. Using partial least square regression, the error of prediction for the α-helix content is reduced after 15-min deuteration. Further deuteration degrades the prediction. Error on the prediction for the “Others” structures also decreases after 15-min deuteration. Cross-validation or a single 25-protein test set result in the same overall conclusions.
Musculature adaption in patients with lumbosacral transitional vertebrae: a matched-pair analysis of 46 patients
Authors: Becker Luis , Ziegeler Katharina , Diekhoff Torsten , Palmowski Yannick , Pumberger Matthias , Schömig Friederike 
Published: February 2021

AbstractObjectiveEven though lumbosacral transitional vertebrae (LSTV) are one of the most common congenital anomalies of the spine, their effect on surrounding soft tissues is not well-studied. We therefore aimed at analyzing the association between LSTV and changes in volume, mass, symmetry, and degeneration of lumbar and trunk muscles.Materials and methodsAbdomen–pelvis CT scans were analyzed in patients with LSTV and a matched control group. LSTV were classified according to the Castellvi classification. Muscles were segmented from the remaining soft tissue and their cross-sectional area and volume were examined at five defined levels. Threshold segmentation was used to differentiate between muscle fibers and fat tissue. Matched pairs were compared using Wilcoxon rank sum tests. For comparison of categorical data, chi-squared tests were performed and for associations between the degree of fusion and muscle size and degeneration, Spearman’s correlation coefficients were calculated. Inter- and intrarater reliabilities were evaluated by computing intraclass correlation coefficients.ResultsForty-six patients with LSTV and 46 controls were included. Muscle volume of the paraspinal and trunk muscles was significantly lower (707.0 cm3vs. 809.7 cm3,p < 0.001) and fatty muscle changes were significantly increased in all but the caudal paravertebral muscles of LSTV patients (M. psoasp < 0.04, M. quadratus lumborump < 0.001, paravertebral musclesp = 0.011, M. rectus abdominisp < 0.001, M. obliquus abdominisp < 0.001). Correlations between the degree of Castellvi classification and muscle volume were significant (p = 0.001).ConclusionLSTV are associated with a reduction in muscle volume and an increase in muscle degeneration of both lumbar and trunk muscles.
When and how should peritoneal endometriosis be operated on in order to improve fertility rates and symptoms? The experience and outcomes of nearly 100 cases
Authors: Dückelmann A. M. , Taube E. , Abesadze E. , Chiantera V. , Sehouli J. , Mechsner S. 
Published: February 2021

Abstract
Purpose
To analyze the follow-up results of patients suffering from symptomatic early-stage endometriosis after a consistent laparoscopic peritoneal stripping of the altered peritoneum (peritoneal endometriosis and surrounding inflamed tissue) was performed. This type of endometriosis is resistant to medical therapy and/or impairs fertility.

Methods
Using our prospectively maintained database, we were able to identify all symptomatic women with the suspicion of only peritoneal endometriosis who underwent laparoscopy at our endometriosis center over a period of 5 years. All procedures were carried out in a standardized fashion by one single surgeon, who is highly experienced in minimal invasive surgery, and included a suspended hormonal pretreatment for 2 months. Postoperative outcomes including complications, fertility and recurrence rates were analysed.

Results
Laparoscopic peritonectomy was performed on 94 women. Follow-up data were available in 87% of these cases. At the time of surgery, almost all patients tested showed signs of stage I or II endometriosis (44.7 and 48.9%, respectively). More than three-quarters of the women reported pain relief, inter alia, due to the post-surgical hormonal therapy. About one-third of the patients wanted to have children after the procedure. 62% of them became pregnant and the majority did so without the need for assisted reproductive therapy. In seven women a re-operation was performed.

Conclusion
According to our data, a consistent excision of altered peritoneum followed by adjuvant hormonal therapy and multimodal concepts results in better outcomes for the patient, particularly in regards to pregnancy and recurrence rates.
Impact of COVID-19 on longitudinal ophthalmology authorship gender trends
Authors: Nguyen Anne X. , Trinh Xuan-Vi , Kurian Jerry , Wu Albert Y. 
Published: February 2021

Abstract
Background
The COVID-19 pandemic increased the gender gap in academic publishing. This study assesses COVID-19’s impact on ophthalmology gender authorship distribution and compares the gender authorship proportion of COVID-19 ophthalmology-related articles to previous ophthalmology articles.

Methods
This cohort study includes authors listed in all publications related to ophthalmology in the COVID-19 Open Research Dataset and CDC COVID-19 research database. Articles from 65 ophthalmology journals from January to July 2020 were selected. All previous articles published in the same journals were extracted from PubMed. Gender-API determined authors’ gender.

Results
Out of 119,457 COVID-19-related articles, we analyzed 528 ophthalmology-related articles written by 2518 authors. Women did not exceed 40% in any authorship positions and were most likely to be middle, first, and finally, last authors. The proportions of women in all authorship positions from the 2020 COVID-19 group (29.6% first, 31.5% middle, 22.1% last) are significantly lower compared to the predicted 2020 data points (37.4% first, 37.0% middle, 27.6% last) (p < .01). The gap between the proportion of female authors in COVID-19 ophthalmology research and the 2020 ophthalmology-predicted proportion (based on 2002–2019 data) is 6.1% for overall authors, 7.8% for first authors, and 5.5% for last and middle authors. The 2020 COVID-19 authorship group (1925 authors) was also compared to the 2019 group (33,049 authors) based on journal category (clinical/basic science research, general/subspecialty ophthalmology, journal impact factor).

Conclusions
COVID-19 amplified the authorship gender gap in ophthalmology. When compared to previous years, there was a greater decrease in women’s than men’s academic productivity.
Interobserver reproducibility of perineural invasion of prostatic adenocarcinoma in needle biopsies
Authors: Egevad Lars , Delahunt Brett , Samaratunga Hemamali , Tsuzuki Toyonori , Olsson Henrik , Ström Peter , Lindskog Cecilia , Häkkinen Tomi , Kartasalo Kimmo , Eklund Martin , Ruusuvuori Pekka 
Published: February 2021

AbstractNumerous studies have shown a correlation between perineural invasion (PNI) in prostate biopsies and outcome. The reporting of PNI varies widely in the literature. While the interobserver variability of prostate cancer grading has been studied extensively, less is known regarding the reproducibility of PNI. A total of 212 biopsy cores from a population-based screening trial were included in this study (106 with and 106 without PNI according to the original pathology reports). The glass slides were scanned and circulated among four pathologists with a special interest in urological pathology for assessment of PNI. Discordant cases were stained by immunohistochemistry for S-100 protein. PNI was diagnosed by all four observers in 34.0% of cases, while 41.5% were considered to be negative for PNI. In 24.5% of cases, there was a disagreement between the observers. The kappa for interobserver variability was 0.67–0.75 (mean 0.73). The observations from one participant were compared with data from the original reports, and a kappa for intraobserver variability of 0.87 was achieved. Based on immunohistochemical findings among discordant cases, 88.6% had PNI while 11.4% did not. The most common diagnostic pitfall was the presence of bundles of stroma or smooth muscle. It was noted in a few cases that collagenous micronodules could be mistaken for a nerve. The distance between cancer and nerve was another cause of disagreement. Although the results suggest that the reproducibility of PNI may be greater than that of prostate cancer grading, there is still a need for improvement and standardization.
Development of a valve type semi-closed extracorporeal circulation system
Authors: Okumura Takahiro , Matsuda Keisuke , Fukuoka Yu , Dai Junya , Shiraishi Naoko 
Published: February 2021

AbstractIn Japan, perfusionists who work on other clinical tasks are involved in cardiopulmonary bypass. Moreover, the number of cases they can perform is limited. In view of this situation, valve type semi-closed extracorporeal circulation (VACC) was developed as a system that enables extracorporeal circulation (ECC) regardless of perfusionists’ experience. The VACC circuit is based on a conventional open-type ECC circuit. A safety valve is installed at the outlet of the reservoir. It is closed by lowering the reservoir pressure below the venous circuit pressure (Pv), thereby providing a closed-type ECC in which the reservoir is separated from the venous circuit (V-circuit). A closed-type ECC needs means to cope with negative pressure generated in the V-circuit and to remove air mixed in the V-circuit. Water experiments to verify the safety of the VACC were conducted. In experiments simulating low venous return, when the Pv dropped, the safety valve opened so that the V-circuit was connected to the reservoir, and the excessive negative pressure was relieved. In the VACC circuit, a bubble trap is installed in the V-circuit, and the air is degassed to the reservoir by a roller pump (D-pump). A water experiment was conducted to verify the principle of the constant degassing method using the D-pump. It verified that the blood storage volume could be maintained constant even if the D-pump is continuously driven. The VACC system provides handling of air mixed in the V-circuit and safety in the case of low venous return.
The Anti-Jewish Narrative
Authors: Cofnas Nathan 
Published: February 2021

AbstractAccording to the mainstream narrative about race, all groups have the same innate dispositions and potential, and all disparities—at least those favoring whites—are due to past or present racism. Some people who reject this narrative gravitate toward an alternative, anti-Jewish narrative, which sees recent history in terms of a Jewish/gentile conflict. The most sophisticated promoter of the anti-Jewish narrative is the evolutionary psychologist Kevin MacDonald. MacDonald argues that Jews have a suite of genetic adaptations—including high intelligence and ethnocentrism—and cultural practices that lead them to undermine gentile society to advance their own evolutionary interests. He says that Jewish-designed intellectual movements have weakened gentile identity and culture while preserving Jewish identity and separatism. Cofnas recently argued that MacDonald’s theory is based on “systematically misrepresented sources and cherry-picked facts.” However, Cofnas gave short shrift to at least three key claims: (a) Jews are highly ethnocentric, (b) liberal Jews hypocritically advocate liberal multiculturalism for gentiles/gentile countries but racial purity and separatism for Jews/Israel, and (c) Jews are responsible for liberalism and mass immigration to the United States. The present paper examines these claims and concludes that MacDonald’s views are not supported.
Diffusion and persistence of false rumors in social media networks: implications of searchability on rumor self-correction on Twitter
Authors: Eismann Kathrin 
Published: February 2021

AbstractSocial media networks (SMN) such as Facebook and Twitter are infamous for facilitating the spread of potentially false rumors. Although it has been argued that SMN enable their users to identify and challenge false rumors through collective efforts to make sense of unverified information—a process typically referred to as self-correction—evidence suggests that users frequently fail to distinguish among rumors before they have been resolved. How users evaluate the veracity of a rumor can depend on the appraisals of others who participate in a conversation. Affordances such as the searchability of SMN, which enables users to learn about a rumor through dedicated search and query features rather than relying on interactions with their relational connections, might therefore affect the veracity judgments at which they arrive. This paper uses agent-based simulations to illustrate that searchability can hinder actors seeking to evaluate the trustworthiness of a rumor’s source and hence impede self-correction. The findings indicate that exchanges between related users can increase the likelihood that trustworthy agents transmit rumor messages, which can promote the propagation of useful information and corrective posts.
Local preferences and the allocation of attention in equity-based crowdfunding
Authors: Bade Marco , Walther Martin 
Published: February 2021

AbstractThis study examines drivers of investment probability in equity-based crowdfunding using a hand-collected and comprehensive data set from a well-established platform. The analysis confirms several effects that have been reported in the recent literature on other crowdfunding markets. Extending recent research, we study moderators of local preferences of investors. Novel to the literature, we find that (1) local preferences are more pronounced in campaigns of younger ventures, (2) herding-like behaviour is stronger in local campaigns and (3) local investors are more responsive to updates posted by entrepreneurs, compared to non-locals. Our results suggest that investors allocate more attention to campaigns for which they have information advantages, such as local campaigns, due to their limited capacity to process information. Such behaviour may eventually amplify information asymmetry and local preferences. Our findings have practical implications for entrepreneurs, investors and platforms.
Timing attacks and local timing attacks against Barrett’s modular multiplication algorithm
Authors: Mittmann Johannes , Schindler Werner 
Published: February 2021

AbstractMontgomery’s and Barrett’s modular multiplication algorithms are widely used in modular exponentiation algorithms, e.g. to compute RSA or ECC operations. While Montgomery’s multiplication algorithm has been studied extensively in the literature and many side-channel attacks have been detected, to our best knowledge no thorough analysis exists for Barrett’s multiplication algorithm. This article closes this gap. For both Montgomery’s and Barrett’s multiplication algorithm, differences of the execution times are caused by conditional integer subtractions, so-called extra reductions. Barrett’s multiplication algorithm allows even two extra reductions, and this feature increases the mathematical difficulties significantly. We formulate and analyse a two-dimensional Markov process, from which we deduce relevant stochastic properties of Barrett’s multiplication algorithm within modular exponentiation algorithms. This allows to transfer the timing attacks and local timing attacks (where a second side-channel attack exhibits the execution times of the particular modular squarings and multiplications) on Montgomery’s multiplication algorithm to attacks on Barrett’s algorithm. However, there are also differences. Barrett’s multiplication algorithm requires additional attack substeps, and the attack efficiency is much more sensitive to variations of the parameters. We treat timing attacks on RSA with CRT, on RSA without CRT, and on Diffie–Hellman, as well as local timing attacks against these algorithms in the presence of basis blinding. Experiments confirm our theoretical results.
The role of embodiment in the treatment of patients with anorexia and bulimia nervosa: a 2-year follow-up study proposing an integration between enhanced cognitive behavioural therapy and a phenomenological model of eating disorders
Authors: Rossi Eleonora , Castellini Giovanni , Cassioli Emanuele , Sensi Carolina , Mancini Milena , Stanghellini Giovanni , Ricca Valdo 
Published: February 2021

Abstract
Purpose
Recent studies demonstrated that the embodiment disorder represents a core feature of eating disorders (EDs). The aim of this study was to evaluate the role of its variation as a possible mediator of the efficacy of enhanced cognitive behavioural therapy (CBT-E) on classic ED symptomatology, including body uneasiness.

Methods
73 patients with anorexia nervosa and 68 with bulimia nervosa were treated with a multidisciplinary approach including CBT-E. Psychometric questionnaires were administered at baseline (T0) and after one (T1) and 2 years (T2) to evaluate general and ED-specific psychopathology, body uneasiness and the embodiment disorder. Data regarding diagnostic crossover and remission were also collected.

Results
Longitudinal analysis showed an improvement of all psychopathological dimensions at T1, which remained stable at T2 (p < 0.05). Remission rate at T2 was 44.7%, and diagnostic crossover occurred in 17.0% of patients. Higher levels of embodiment disorder predicted increased diagnostic instability (OR: 1.80 [1.01–3.20], p = 0.045). The amelioration of the embodiment disorder mediated the decrease in both ED-specific psychopathology (indirect effect: 0.67 [0.46–0.92]) and body uneasiness (indirect effect: 0.43 [0.28–0.59]).

Conclusion
For the first time, these findings highlighted the role of the embodiment disorder as a maintaining factor of ED symptomatology, supporting the importance of integrating CBT-E with a phenomenological model of EDs.

Level of evidence
Level IV, longitudinal observational study (case series).