bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between Interleukin 6 Serum Levels and Degree of Depression in Systemic Lupus Erythematosus Patients Internal Disease in Dr. Moh Hoesin Palembang
Authors: Suharno Shinta , Eddy Mart Salim  , Ali Apriansyah  , Taufik Indrajaya  , Zen Ahmad  , Erial Bahar  
Published: December 2021

Introduction. Systemic Lupus Erythematosus (LES) is a chronic autoimmune inflammatory disease affecting many organ systems with varied clinical manifestations, disease course and prognosis. One of the clinical manifestations that can occur is depression as much as 25%. In LES patients, there is an increase in proinflammatory cytokines, one of which is IL-6, which is often associated with contributing to the pathophysiology of depression. The purpose of this study was to determine the relationship between serum IL-6 levels and the degree of depression in LES patients at RSUP DR. Mohammad Hoesin Palembang.
Methods. Analytic observational study in the form of correlation test with cross sectional design which was conducted in the Internal Medicine room RSUP DR. Mohammad Hoesin Palembang from May 2019 to March 2020. The number of study subjects was 40 samples who were LES patients with depression who had been calculated using the BDI (Beck's Depression Inventory). All subjects were examined for serum IL-6 levels and evaluated for factors that influence it.
Results. There were 40 study subjects aged 18-56 years. The median degree of depression was 16 with a range of values from 10 to 40. There were 17 people (42.5%) with mild depression degree, 14 people (35%) moderate depression, and 9 people (22.5%) major depression. In LES activities, there were 5 people (12.5%) with light LES activities, 20 people (50%) with moderate LES activities, and 15 people (37.5%) with heavy LES activities. The mean serum IL-6 level was 11.57 pg / mL with a value range of 1.1-50pg / mL. There was a significant correlation between the degree of depression and LES activity (p = 0.004; r = 0.444) and between serum IL-6 levels and the degree of depression (p = 0.025; r = 0.169). However, there was no significant correlation between serum IL-6 levels and LES activity (p = 0.057; r = 0.304).
Conclusion. There is a relationship between serum IL-6 levels and the degree of depression in LES patients at Dr. Moh. Hoesin Palembang with a very weak correlation.
Characteristics Giant Cell Tumor of The Bone Cases at Dr. Mohammad Hoesin General Hospital Period 1 January 2017 - 31 Augsut 2020
Authors: Rubiansyah Primadika , Septiandani Randy Rakhmat 
Published: December 2021

Introduction : Giant Cell Tumor (GCT) is a benign bone tumors with potentially aggressive and capacity to metastasize. This tumor could destroy the bone and joint component. As a primary bone tumor that appears at productive age , GCT can cause morbidity for patients.
Methods : This research is a retrospective descriptive study with data obtained from the medical records of patients who went to Mohammad Hoesin general hospital for the period January 1, 2017- August 31, 2019. Data processing was carried out using SPSS 16.0. From the research results, 27 GCT patient data that met the inclusion criteria were obtained.
Results : There were 23 (85.1%) patients in the 20-44 years age group, 2 (7.4%) people <20 years, 2 (7.4%) people> 44 years. There were 13 (48%) male patients and 14 (52%) female patients. The most common tumor locations were in the proximal tibia as many as 6 (22%) people, Distal Femur as many as 6 (22%) people, Distal Radius as many as 5 (18.5%) people, Distal Ulna as many as 3 (11.1%) people, Proximal Femur as many as 1 (3.7 %) people, Calcaneus as much as 1 (3.7%) people, Metacarpal as many as 1 (3.7%) people. Based on grading Campanacci, 16 (59.25%) people had GCT with Campanacci Grade III, Grade II with 8 (29.6%) people, and 1 (3.7%) grade I. Only 2 (7.4%) people had recurrences. No patients were found to have lung metastases (0%). There were 1 (3.7%) patients with pathological fracture on GCT. Management carried out was 24 people undergoing resection and reconstruction 24 (88.5%) and 3 (11.5%) people with curettage and bone cement.
Conclusion : This study of GCTB at Mohammad Hoesin general hospital bring out that patient’s characteristics are similar with other country and theory. Mostly patient got GCTB at age second until fouth decade of life, slightly more in female, mostly tumor detected around the knee. Mostly patient detected with Campanacci graded III and needed resection and reconstruction surgery. No reported lung metastases in GCTB patient but this record need further follow up due to short time between surgery and study
Profile of Breast Cancer Patients at Dr. Moewardi Surakarta Period March 2016 - March 2018
Authors: Dwiyanto Randi , Widyanti Soewoto  
Published: December 2021

Introduction: Breast cancer is a heterogeneous disease caused by the interaction of genetic factors and environmental risk factors that lead to the accumulation of progressive genetic and epigenetic changes in breast cancer cells. The incidence of breast cancer in Indonesia is 11% of all cancer incidents. There are many factors that are thought to have an influence on the occurrence of breast cancer, including age, immunohistochemistry, and variable levels of first breast carcinoma at old age.
Methods: A descriptive retrospective study by taking medical record data about breast cancer at the Dr. Moewardi General Hospital, Surakarta. at the Installation of Medical Records at the General Hospital DR. Moewardi Period February 2016 - February 2018.
Results: According to the age group of 50 years, 162 patients (54%) and above who had a high risk and under 50 years group were 138 patients (46%). From the results of the study, breast cancer patients with grade 3 were found to be the most with 155 cases (51.67%). Hormonal receptor detection in breast cancer patients showed a high incidence of HER-2-negative patients as many as 172 patients (57.33%). The rest showed positive HER-2 results as many as 128 patients (42.67%). There was a high incidence of negative HER-2 as many as 172 patients (57.33%). The rest showed positive HER-2 results as many as 128 patients (42.67%). Positive HER-2 subtypes (ER-, PR-, HER2 +) were the most common cases, namely 128 cases (42.67%). The magnitude of the correlation (Phi and Cramer) produces the same number, while the contingency coefficient produces a smaller number.
Conclusion: There is almost no relationship or there is a very weak relationship between age, immunohistochemistry, and variable rates of breast carcinoma, variable rates of breast carcinoma at the occurrence of metastases.
The Risk Factors Affecting Disability Level of Lumbar Disc Herniation
Authors: Yelmaiza Melda , Restu Susanti  , Syarif Indra  
Published: December 2021

Background. Lumbar disc herniation (LDH) is a disorder that involves rupture of the annulus fibrosus so that the nucleus pulposus protrudes and compresses the lumbar canal. LDH is the most common cause of lumbar radiculopathy. LDH causes functional disorders in patients, causing disability to carry out daily activities. The purpose of this study was to determine the risk factors that influence the degree of disability in lumbar nucleus pulposus herniation.
Methods. Analytical research with a consecutive cross-sectional study approach in patients with lumbar LDH at the Neurology Outpatient Clinic, Dr. M. Djamil General Hospital Padang from March to November 2021. The risk factors assessed were age, gender, occupation, length of illness, and body mass index (BMI). The measurement of the degree of disability uses the Oswestry disability index (ODI) score. The relationship between risk factors and the degree of disability was analyzed using chi-square test. Differences in the mean age of groups with mild and moderate degrees of disability using unpaired t-test.
Results. 40 subjects met the inclusion and exclusion criteria. Mean age 57 ± 10,976 years, male and female ratio 1:2, work with heavy lifting activities was found in 70% of subjects, duration of suffering from LDH more than one year in 60% of subjects. BMI overweight and obesity as many as 77.5% subjects. As many as 60% of the subjects experienced mild to moderate degrees of disability. There is a difference in the average age of the subjects with mild to moderate degree of disability with a severe degree of p-value of 0.044. There was no significant relationship between gender (p=0.054), occupation (p=0.398), length of illness (p=0.503) and body mass index (p=0.757), and the degree of disability.
Conclusion. The degree of disability in patients with LDH is influenced by age. Meanwhile, gender, occupation, length of illness and body mass index were not significantly related to the degree of disability in patients.
The impact of the COVID-19 pandemic on the affective filter of EFL learners in an online classroom
Authors: Rivera Gallardo Ximena Patricia , Matts Janine 
Published: December 2021

Introduction: the integration of technology in language teaching, especially in the context of the COVID-19 pandemic caused the search for different pedagogical strategies. Due to this drastic change in education along with the rapid access to online resources have placed technology as the most important tool in teaching. Therefore, when planning a class, the teacher must consider digital tools and dynamic methodologies to streamline and motivate students to reduce their affective filter. Objective: the current research aims to determine the effectiveness of Kahoot in the reduction of the impact of the EFL students’ affective filter. Methods: this study developed applied research with a mixed method approach and descriptive scope, with a quasi-experimental design. 42 students actively participated. For the data gathering, two main tools of data collection were used, namely a survey to look for information about the impact of students’ affective filter during the virtual classes and a pre and post-test based on reading comprehension to check the students’ English performance. Conclusions: the students are facing negative experiences in their learning of English because their affective filter is high. Besides, after the intervention phase with the use of Kahoot, the students improved their English performance in the reading comprehension skill. Therefore, it is suggested to continue sampling innovative technological resources to enhance students’ performance.
Performance of Sequential Organ Failure Assessment and Simplified Acute Physiology Score II for Post-Cardiac Surgery Patients in Intensive Care Unit
Authors: Xu Fei , Li Weina , Zhang Cheng , Cao Rong 
Published: December 2021

Background: The aim of this study is to assess the performance of Sequential Organ Failure Assessment (SOFA) score and Simplified Acute Physiology Score (SAPS II) on outcomes of patients with cardiac surgery and identify the cutoff values to provide a reference for early intervention.Methods: All data were extracted from MIMIC-III (Medical Information Mart for Intensive Care-III) database. Cutoff values were calculated by the receiver-operating characteristic curve and Youden indexes. Patients were grouped, respectively, according to the cutoff values of SOFA and SAPS II. A non-adjusted model and adjusted model were established to evaluate the prediction of risk. Comparison of clinical efficacy between two scoring systems was made by decision curve analysis (DCA). The primary outcomes of this study were in-hospital mortality, 28-day mortality, 90-day mortality, and 1-year mortality after cardiac surgery. The secondary outcomes included length of hospital stay and intensive care unit (ICU) stay and the incidence of acute kidney injury (AKI) within 7 days after ICU admission.Results: A total of 6,122 patients were collected and divided into the H-SOFA group (SOFA ≥ 7) and L-SOFA group (SOFA &lt; 7) or H-SAPS II group (SAPS II ≥ 43) and L-SAPS II group (SAPS II &lt; 43). In-hospital mortality, 28-day mortality, 90-day mortality, and 1-year mortality were higher, the length of hospital and ICU stay were longer in the H-SOFA group than in the L-SOFA group (p &lt; 0.05), while the incidence of AKI was not significantly different. In-hospital mortality, 28-day mortality, 90-day mortality, 1-year mortality, and the incidence of AKI were all significantly higher in the H-SAPS II group than in the L-SAPS II group (p &lt; 0.05). Hospital stay and ICU stay were longer in the H-SAPS II group than in the L-SAPS II group (p &lt; 0.05). According to DCA, the SAPS II scoring system had more net benefits on assessing the long-term mortality compared with the SOFA scoring system.Conclusion: Exceeding the cutoff values of SOFA and SAPS II scores could lead to increased mortality and extended length of ICU and hospital stay. The SAPS II scoring system had a better discriminative performance of 90-day mortality and 1-year mortality in post-cardiac surgery patients than the SOFA scoring system. Emphasizing the critical value of the scoring system is of significance for timely treatment.
An Automated Dashboard to Improve Laboratory COVID-19 Diagnostics Management
Authors: Maury Emma , Boldi Marc-Olivier , Greub Gilbert , Chavez Valérie , Jaton Katia , Opota Onya 
Published: December 2021

Background: In response to the COVID-19 pandemic, our microbial diagnostic laboratory located in a university hospital has implemented several distinct SARS-CoV-2 RT-PCR systems in a very short time. More than 148,000 tests have been performed over 12 months, which represents about 405 tests per day, with peaks to more than 1,500 tests per days during the second wave. This was only possible thanks to automation and digitalization, to allow high throughput, acceptable time to results and to maintain test reliability. An automated dashboard was developed to give access to Key Performance Indicators (KPIs) to improve laboratory operational management.Methods: RT-PCR data extraction of four respiratory viruses—SARS-CoV-2, influenza A and B and RSV—from our laboratory information system (LIS), was automated. This included age, gender, test result, RT-PCR instrument, sample type, reception time, requester, and hospitalization status etc. Important KPIs were identified and the visualization was achieved using an in-house dashboard based on the open-source language R (Shiny).Results: The dashboard is organized into three main parts. The “Filter” page presents all the KPIs, divided into five sections: (i) general and gender-related indicators, (ii) number of tests and positivity rate, (iii) cycle threshold and viral load, (iv) test durations, and (v) not valid results. Filtering allows to select a given period, a dedicated instrument, a given specimen, an age range or a requester. The “Comparison” page allows a custom charting of all the available variables, which represents more than 182 combination. The “Data” page, gives the user an access to the raw data in tables format, with possibility of filtering, allowing for a deeper analysis and data download. Informations are updated every 4 h.Conclusions: By giving a rapid access to a huge number of up-to-date information, represented using the most relevant visualization types, without the burden of timely data extraction and analysis, the dashboard represents a reliable and user-friendly tool for operational laboratory management. The dashboard represents a reliable and user-friendly tool improving the decision-making process, resource planning and quality management.
Bandgap Correction and Spin-Orbit Coupling Induced Absorption Spectra of Dimethylammonium Lead Iodide for Solar Cell Absorber
Authors: Agbaoye Ridwan O. , Bolarinwa Sherifdeen , Akiode Kolawole Olubunmi , Adekoya-Olowofela Abibat A. , Habeeb Lateefat Modupe , Balogun Omolola Myriam , Adebambo Paul O. , Kenmoe Stephane , Adebayo Gboyega A. 
Published: December 2021

The search for stable and highly efficient solar cell absorbers has revealed interesting materials; however, the ideal solar cell absorber is yet to be discovered. This research aims to explore the potentials of dimethylammonium lead iodide (CH3NH2CH3PbI3) as an efficient solar cell absorber. (CH3NH2CH3PbI3) was modeled from the ideal organic–inorganic perovskite cubic crystal structure and optimized to its ground state. Considering the spin-orbit coupling (SOC) effects on heavy metals, the electronic band structure and bandgaps were calculated using the density functional theory (DFT). In contrast, bandgap correction was achieved by using the GW quasiparticle methods of the many-body perturbation theory. The optical absorption spectra were calculated from the real and imaginary dielectric tensors, which are determined by solving the Bethe–Salpeter equations of the many-body perturbation theory. Spin-orbit coupling induces band splitting and bandgap reduction in both DFT and GW methods, while the GW method improves the DFT bandgap. We report a DFT band gap of 1.55 eV, while the effect of spin-orbit coupling reduces the bandgap to 0.50 eV. Similarly, the self-consistent GW quasiparticle method recorded a bandgap of 2.27 eV, while the effect of spin-orbit coupling on the self-consistent GW quasiparticle method reported a bandgap of 1.20 eV. The projected density of states result reveals that the (CH3NH2CH3PbI3) does not participate in bands around the gap, with the iodine (I) p orbital and the lead (Pb) p orbital showing most prominence in the valence band and the conduction band. The absorption coefficient reaches 106 in the ultraviolet, visible, and near-infrared regions, which is higher than the absorption coefficient of CH3NH3PbI3. The spectroscopic limited maximum efficiency predicts a high maximum efficiency of about 62% at room temperature and an absorber thickness of about 10–1 to 102 μm, suggesting that (CH3NH2CH3PbI3) has an outstanding prospect as a solar cell absorber.
TNFRSF11B Suppresses Memory CD4+ T Cell Infiltration in the Colon Cancer Microenvironment: A Multiomics Integrative Analysis
Authors: Zhang Jun-rong , Hou Ping , Wang Xiao-jie , Weng Zong-qi , Shang-guan Xin-chang , Wang Hui , You Fang , Lin Bing-qiang , Huang Zheng-yuan , Chen Xian-qiang 
Published: December 2021

BackgroundColorectal cancer is a lethal cancer worldwide. Due to the low tumor mutation burden and low proportion of tumor-infiltrating lymphocytes in the microenvironment of most patients, innovative immunotherapeutic approaches need to be identified.MethodsUsing the TCGA-COAD dataset (n = 514), we identified TNFRSF11B as a prognostic factor of colon cancer. An immunohistochemistry (IHC) dataset (n = 86), 290 single colorectal cancer cells (GSE81861), and 31 paired colon cancer transcriptional datasets were further applied to validate the function of TNFRSF11B, which was confirmed via fluorescence-activated cell sorting (FACS) analysis.ResultsA risk score system consisting of eight immune-related genes (IRGs) (FGFR2, ZC3HAV1L, TNFRSF11B, CD79A, IGHV3-11, IGHV3-21, IGKV2D-30, and IGKV6D-21) was constructed to predict the prognosis of colon cancer patients. Only TNFRSF11B was closely correlated with late-stage lymph node metastasis and worse survival outcomes (p = 0.010, p = 0.014, and p = 0.0061). In our IHC dataset, 72.09% (62/86) of the colon cancer patients had TNFRSF11B overexpression with significantly shorter overall survival times (p = 0.072). High TNFRSF11B expression typically had a later TNM stage (p = 0.067), a higher frequency of lymph node (p = 0.029) and lymphovascular (p = 0.007) invasion, and a higher incidence of pneumonia (p = 0.056) than their counterparts. The expression of six genes (KRT18, ARPC5L, ACTG1, ARPC2, EZR, and YWHAZ) related to pathogenic E. coli infection was simultaneously increased with TNFRSF11B overexpression via gene set enrichment analysis (GSEA). These genes are involved in the regulation of the actin cytoskeleton, shigellosis, bacterial invasion of epithelial cells, and Salmonella infection. Finally, only activated memory CD4+ T cells (p = 0.017) were significantly decreased in the high TNFRSF11B expression group via CIBERSORT comparison, which was confirmed by TIMER2.0 analysis of the TCGA-COAD dataset. We also performed FACS analysis to show that TNFRSF11B decreased the infiltration of central memory CD4+ T cells and effector memory CD4+ T cells in the colorectal cancer microenvironment (all p &lt;0.001).ConclusionTNFRSF11B acts as a prognostic factor for colon cancer patients and could affect the colon cancer immune response. TNFRSF11B was closely related to lymph node invasion and pathogenic E. coli. infection, which may negatively affect memory-activated CD4+ T cell infiltration in colon cancer.
The Morphological, Clinical and Radiological Outputs of the Preclinical Study After Treatment of the Osteochondral Lesions in the Porcine Knee Model Using Implantation of Scaffold Based on the of Calcium Phosphate Biocement
Authors: Vdoviaková Katarína , Danko Ján , Krešáková Lenka , Šimaiová Veronika , Petrovová Eva , Novotný Jaroslav , Žert Zděnek , Koľvek Filip , Valocký Igor , Varga Maroš , Špakovská Tatiana , Pribula Jozef , Gašpárek Miroslav , Giretova Mária , Štulajterova Radoslava , Medvecký Ľubomír 
Published: December 2021

The symptomatic full-thickness cartilage lesions or cartilage degeneration leads to the destruction of the normal chondral architecture and bone structure in affected area, causes the osteoarthritis, and general damage to the health. Knee joints are most frequently affected by this condition. The permanent damage of the articular cartilage and subchondral bone has motivated many scientists and clinicians to explore new methods of regeneration of osteochondral defects, such as novel materials.We studied the potential of the biocement based on calcium phosphate consisting of a mixture of four amino acids (glycine, proline, hydroxyproline and lysine) in the regenerating process of the artificially created osteochondral defect on the porcine medial femoral condyle in the stifle joint. The mass ratio of the amino acids in biocement CAL was 4:2:2:1. The Ca/P ratio in cement was 1.67 which correspond with ratio in hydroxyapatite. We compared the results with spontaneous healing of an artificially created cyst with that of the healthy tissue. The animal group treated with biocement paste CAL presented completely filled osteochondral defects. The results were confirmed by histological and radiological assessments, which have shown regenerated chondral and bone tissue in the examined knee joints. Macroscopic evaluation showed that neocartilage was well integrated with the adjacent native cartilage in animal group with biocement CAL, compared with healing of the artificial cyst, where treated cartilage surfaces were visibly lower than the surrounding native cartilage surface and a border between native and restored tissue was apparent. The qualitative assessment of the implant histology specimens showed full regeneration of the hyaline cartilage and subchondral bone in animals with biocement CAL. The artificial cyst group showed remarkable fibrillation. The detailed MRI analysis of cross-section of osteochondral defect confirmed the complete cartilage and subchondral bone healing where the thickness of the regenerated cartilage was 1.5 mm. The MRI imaging of defects in the artificial cyst group showed incomplete healing, neo cartilage tissue reduced up to 50%.