bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monolayer graphene membranes for molecular separation in high-temperature harsh organic solvents
Authors: Lu Yanqiu , Zhang Liling , Shen Liang , Liu Wei , Karnik Rohit , Zhang Sui 
Published: September 2021

Significance
Tremendous amounts of organic solvents are used in industry, requiring chemical-resistant membranes for energy-efficient solvent recovery. Currently, organic solvent nanofiltration (OSN) is hindered by the instability of membranes in operation, in particular under high temperatures and in harsh solvents. In this research, we revealed the solvent transport across nanopores of single-layer graphene via molecular dynamics simulation and combined it with a resistance model to guide the design of a defect-tolerant graphene composite membrane for OSN. The graphene-covered membrane demonstrated high permeance and excellent resistance to DMF at high temperatures, offering possibilities for challenging separations.
Stagnation points control chaotic fluctuations in viscoelastic porous media flow
Authors: Haward Simon J. , Hopkins Cameron C. , Shen Amy Q. 
Published: September 2021

SignificanceViscoelastic porous media flows become chaotic beyond critical flow conditions, impacting processes including enhanced oil recovery and targeted drug delivery. Understanding how geometric details of the porous medium affect the onset and strength of the chaotic flows can lead to fundamental insights and potential optimization of such processes. Recently, it has been argued that geometric disorder in the medium suppresses chaotic fluctuations. In contrast, we demonstrate that disorder can also significantly enhance fluctuations given a different originally ordered configuration. We show that the occurrence of stagnation points in the flow field is the vital factor controlling the onset and strength of fluctuation, providing a general and intuitive understanding of how pore geometry affects this important class of complex viscoelastic flows.
Bidirectionality between modal and conditional constructions in Mandarin Chinese
Authors: Kuo Yueh Hsin 
Published: September 2021

AbstractThis paper proposes that modal constructions can develop into conditional constructions in Mandarin Chinese and vice versa. Therefore, bidirectionality exists between these kinds of constructions diachronically. While bidirectionality is an apparent violation of unidirectionality, both directions of change are shown to be regular cases of procedural constructionalization, enabled by the fact that modal and conditional constructions can perform identical indirect speech acts (i.e., they are performatively equivalent) and instances of one may be morphosyntactically categorized as the other in Chinese (i.e., they are morphosyntactically vague). A crosslinguistically generalizable prediction is then proposed: bidirectionality is possible if instances of two constructions are performatively equivalent and morphosyntactically vague with respect to each other in certain contexts.
Grammatical gender in Spanish child heritage speakers
Authors: Martinez-Nieto Lourdes , Restrepo Maria Adelaida 
Published: September 2021

Abstract
This study examines grammatical gender (GG) production in young Spanish heritage-speakers (HSs) and the potential
effect of the children’s language use and their parents’ input. We compared four and eight-year-old HSs to same-age monolingual
children on their gender production. We measured GG production in determiners and adjectives via an elicited production task. HSs’
parents reported children’s time in each language and also completed the elicitation task. Results show that HSs’ scored
significantly lower than monolinguals in both grammatical structures in which the unmarked masculine default predominates.
However, older HSs had higher accuracy than younger HSs. Input from parents is not correlated with HSs’ performance and neither
Spanish use nor language proficiency predicts GG performance on HSs. For theories of language acquisition, it is important to
consider that although the linguistic knowledge of the HSs may differ from that of monolinguals, their grammar is protracted
rather than incomplete.
Cryptostegia grandiflora (rubber vine).
Authors: Rojas-Sandoval Julissa , Acevedo-Rodríguez Pedro 
Published: September 2021

Abstract

C. grandiflora is a highly invasive weed in semi-arid natural ecosystems, especially dry or monsoonal rainforest. It has the potential to spread much further, especially in Australia where it poses a threat to national parks. The historical evidence suggests that there is a significant lag period before the plant assumes an invasive status. Thus, those countries where the plant has been cultivated as an ornamental or as a crop, but where it has not yet become invasive, are at future risk of invasion.
Tensor electrical impedance myography identifies clinically relevant features in amyotrophic lateral sclerosis
Authors: Schooling Chlöe N , Jamie Healey T , McDonough Harry E , French Sophie J , McDermott Christopher J , Shaw Pamela J , Kadirkamanathan Visakan , Alix James J P 
Published: September 2021

Abstract

Objective. Electrical impedance myography (EIM) shows promise as an effective biomarker in amyotrophic lateral sclerosis (ALS). EIM applies multiple input frequencies to characterise muscle properties, often via multiple electrode configurations. Herein, we assess if non-negative tensor factorisation (NTF) can provide a framework for identifying clinically relevant features within a high dimensional EIM dataset. Approach. EIM data were recorded from the tongue of healthy and ALS diseased individuals. Resistivity and reactivity measurements were made for 14 frequencies, in three electrode configurations. This gives 84 (2 × 14 × 3) distinct data points per participant. NTF was applied to the dataset for dimensionality reduction, termed tensor EIM. Significance tests, symptom correlation and classification approaches were explored to compare NTF to using all raw data and feature selection. Main Results. Tensor EIM provides highly significant differentiation between healthy and ALS patients (p < 0.001, AUROC = 0.78). Similarly tensor EIM differentiates between mild and severe disease states (p < 0.001, AUROC = 0.75) and significantly correlates with symptoms (ρ = 0.7, p < 0.001). A trend of centre frequency shifting to the right was identified in diseased spectra, which is in line with the electrical changes expected following muscle atrophy. Significance. Tensor EIM provides clinically relevant metrics for identifying ALS-related muscle disease. This procedure has the advantage of using the whole spectral dataset, with reduced risk of overfitting. The process identifies spectral shapes specific to disease allowing for a deeper clinical interpretation.
The effectiveness of composter at the integrated waste treatment plant in the campus of engineering faculty Hasanuddin University
Authors: Lando A T , Rahim I R , Sari K , Djamaludin I , Arifin A N , Nurhidayanti D 
Published: September 2021

Abstract
The weight of domestic solid waste generation at the Faculty of Engineering of Hasanuddin University is 62.60 kg day−1. The percentage of organic waste generation is 28%, so the weight of organic waste generation on this campus is 17.66 kg. One way to utilize organic waste is by composting. There are three methods for composting, including (1) aerobic methods, (2) anaerobic methods, and (3) combining aerobic and anaerobic methods. The method used in measuring waste generation is the measurement of waste generation in ten buildings located on this campus for eight consecutive days, according to the procedures in the Indonesian National Standard. The data used in this study include primary and secondary data. Primary data in this study are the results of measurements of weight, volume, and composition of waste. Whereas, secondary data in this study is the number of the campus population of the Faculty of Engineering. From the primary and secondary data, composter space requirements, effectiveness, and investment evaluation through the Benefit-Cost Ratio of the three composting methods can be calculated. From the calculation results, the space requirements for aerobic composter are 16.08 m2, 16.08 m2 for the anaerobic composter, and 25.61 m2 for combination aerobic and anaerobic composter. The effectiveness values for each composter method were 98.7%, 98.47%, and 98.9% for aerobic, anaerobic composters, and the combination of the two, respectively. Furthermore, the value of the Benefit-Cost Ratio for each composter method is 1.20, 1.38, and 1.85 for aerobic, anaerobic composters, and the combination of the two, respectively.
Estimation of methane emissions from municipal solid waste landfill in makassar city based on ipcc waste model
Authors: Lando A T , Rahim I R , Sari K , Djamaluddin I , Arifin A N , Sari A M 
Published: September 2021

Abstract
One of the greenhouse gases, which is the cause of climate change and global warming is methane gas (CH4). One of the most significant sources of methane that contributes to emissions globally is landfills (anthropogenic sources). Methane emissions from waste are the result of the anaerobic decomposition of organic matter in waste. The more garbage in the landfill without further treatment can lead to greater methane emissions. The site of this study was a municipal solid waste in Makassar city, named Tamangapa landfill, ±15 km from downtown Makassar city. The objectives of this study are to estimate methane emissions in the Tamangapa landfill and estimate methane emissions from the Tamangapa landfill over the next ten years using the 2006 IPCC Waste Model. The results showed that the waste generation in Makassar City, in 2016, was 0.449 kg/person/day with the composition of waste dominated by organic waste. The value of potential methane emissions at TPA Tamangapa Makassar in 2016 is 2.24 Gg/year and the projection in 2026 is 4.968 Gg/year. The mitigation and adaptation efforts that can be recommended are the socialization of 3R techniques (Reduce, Reuse, and Recycle) and construct a sanitary landfill in Makassar city following the mandate of Law No. 18 of 2008.
Behaviour of Mixed Expansive Soil and Additive Minerals as Subgrade Layer
Authors: Sitepu F , Harianto T , Ridwan R , Marfuah N 
Published: September 2021

Abstract
South Sulawesi is one of eastern Indonesia area covered with coastal line which have growth fast of industries. Infrastructure builds and developed in a row of industries population. Most coastal are lowland areas with expansive soil as primary soil forms. Exhaustive laboratory test conducts for clay taken from lowland area in south Sulawesi and lime up to 10% and volcanic up to 25% as stabilizers to know the Physical-mechanical properties and mineralogical when the expansive soil stabilized. The extensive soil stabilized with 5% lime + 15% Volcanic ash presents better performance and pass the roadbed materials requirements. Chemical reactions between soil and the stabilizers increase the pH and electrical conductivity. X-ray diffraction (XRD) and transmission electron microscope (TEM) confirmed new cementing agents’ findings regarding the results of chemical reactions. An explicit effect on controlling the soil deformation and the moisture change shows by the expansive soil stabilized with 5% lime + 15% volcanic ash. The research results find the optimum combination of stabilizers to reduce cost to improve expansive soil from the South Sulawesi lowland area.
The influence of energy-reducing structure placement on friction velocity distribution in open channel
Authors: Widyastuti I , Thaha M A , Lopa R T , Hatta M P 
Published: September 2021

Abstract
Energy Reducing Structure (ERS) is aimed at controlling the flow velocity that causes scouring on the main abutment structure of the bridge from its structural failure. It is needed information on the measurement of flow velocity and other parameters of flow, particularly in analyzing the friction velocity and shear stress on the channel bed to identify the effects of ERS placement on the scouring around the abutment area. The experiment was performed in a flume/channel with a length of 8.00 m, a width of 0.40 m, and a height of 0.40 m. The slope of the channel was 0.05% and 0.15%. The type of flow was uniform turbulent flow, using 3 (three) variation of inlet discharge (Q), with and without Energy Reducing Structure (ERS) in the form of a triangular plate with its height determined based on the average maximum rate of 0.6D from the average water surface of 0.06 m from the channel bed. In measuring the distribution of flow velocity with structure, the measurement was conducted in the upstream and downstream areas of the structure, where the structure was placed at x distance of = 4.00 m. Each measurement was performed at the distance of x = 3.50 m ; x = 4.25 m ; x = 4.50 m ; x = 5.00 and x = 5.50 m. The analysis of friction velocity follows the logarithmic law (log-low) applicable to the open channel. The results of the experiment showed that the smallest friction velocity value (u*) was on average happened at x distance = 4.25 m – x = 4.50 m ranging from 0.70 cm/sec – 1.37 cm/sec, as the friction velocity was decreasing. On the other hand, however, the constant of integration (Br) showed great values ranging from 19.27 – 48.79, which implied that the flow rate after passing ERS had the flow velocity beyond the normal range and it would be back to normal after moving away from ERS.
Factors of causing seawater intrusion in Kadatua Island, Southeast Sulawesi
Authors: Tamrin  , Maricar F , Hatta M P , Arsyad A 
Published: September 2021

Abstract
In the last decade, there has been an increase in the population very rapidly not only in urban areas but throughout the villages of the region in Indonesia. This led to a huge increase in the need for clean water where the availability of surface water has begun not meet the needs, and groundwater ultimately plays an important role in meeting those needs. However, along with the increase in water use soil, there are negative effects that arise when groundwater exploitation becomes excessive and one of the impacts is the occurrence of seawater intrusion which destroys the quality and quality groundwater quantity. It is hoped that the long-term objective of this research will be produced a report on the estimated intrusion of seawater that can be used as a reference to optimize the protection of groundwater resources. For that purpose short term in this research is to produce information/description regarding the current extent of seawater intrusion in Kadatua Island, Southeast Sulawesi based on data obtained from the identification results in the field.
Application of 2D numerical simulation for the analysis of July 2020 North Luwu flood
Authors: Hatta M P , Fadlin F , Harun R , Elfita Y , Renreng I 
Published: September 2021

Abstract
Massamba is a district in North Luwu that is continually flooded by the Massamba river. The flood lasts for several days with tons of suspended materials affecting important places in the city, drowning people, and swamping arable land. Two-dimensional (2D) numerical simulation Hec-RAS is one of the most popular hydraulic models which is proved to be an important tool for analyzing and understanding flood events. The new version of Hec-RAS (5.07) was released and including 2D models capabilities. This study applied the new Hec-Ras version 5.07 to simulate the July 2020 flood in North Luwu. The flood simulate shows good results compared with the observation of the satellite image of the flood event. The simulation result provides some information like velocity, depth, and inundation area. Over the flooded area the depth is lower than 3,88 meters, velocity lower than 2,4 m/s-1, and swamping over 2,3 square kilometers of Massamba city. The flood depth allows identifying areas exposed based to hazard levels based. The simulation result validated by comparing the simulation result to the satellite image and calculating the root mean square error (RMSE) of water depth from the simulation result and during a flood event. The validation result shows that the determination coefficient R2 is 83,66%. The study shows the applicability and the value of the 2D capabilities Hec-RAS for flood studies.
Human iPSC-derived mesodermal progenitor cells preserve their vasculogenesis potential after extrusion and form hierarchically organized blood vessels
Authors: Dogan Leyla , Scheuring Ruben , Wagner Nicole , Ueda Yuichiro , Schmidt Sven , Wörsdörfer Philipp , Groll Jürgen , Ergün Süleyman 
Published: September 2021

Abstract
Post-fabrication formation of a proper vasculature remains an unresolved challenge in bioprinting. Established strategies focus on the supply of the fabricated structure with nutrients and oxygen and either rely on the mere formation of a channel system using fugitive inks or additionally use mature endothelial cells and/or peri-endothelial cells such as smooth muscle cells for the formation of blood vessels in vitro. Functional vessels, however, exhibit a hierarchical organization and multilayered wall structure that is important for their function. Human induced pluripotent stem cell-derived mesodermal progenitor cells (hiMPCs) have been shown to possess the capacity to form blood vessels in vitro, but have so far not been assessed for their applicability in bioprinting processes. Here, we demonstrate that hiMPCs, after formulation into an alginate/collagen type I bioink and subsequent extrusion, retain their ability to give rise to the formation of complex vessels that display a hierarchical network in a process that mimics the embryonic steps of vessel formation during vasculogenesis. Histological evaluations at different time points of extrusion revealed the initial formation of spheres, followed by lumen formation and further structural maturation as evidenced by building a multilayered vessel wall and a vascular network. These findings are supported by immunostainings for endothelial and peri-endothelial cell markers as well as electron microscopic analyses at the ultrastructural level. Moreover, endothelial cells in capillary-like vessel structures deposited a basement membrane-like matrix at the basal side between the vessel wall and the alginate-collagen matrix. After transplantation of the printed constructs into the chicken chorioallantoic membrane (CAM) the printed vessels connected to the CAM blood vessels and get perfused in vivo. These results evidence the applicability and great potential of hiMPCs for the bioprinting of vascular structures mimicking the basic morphogenetic steps of de novo vessel formation during embryogenesis.
Lesion location and lesion creation affect outcomes after focused ultrasound thalamotomy
Authors: Segar David J , Lak Asad M , Lee Shane , Harary Maya , Chavakula Vamsidhar , Lauro Peter , McDannold Nathan , White Jason , Cosgrove G Rees 
Published: September 2021

Abstract
MRI-guided focused ultrasound thalamotomy has been shown to be an effective treatment for medication refractory essential tremor. Here, we report a clinical-radiological analysis of 123 cases of MRI-guided focused ultrasound thalamotomy, and explore the relationships between treatment parameters, lesion characteristics and outcomes.
All patients undergoing focused ultrasound thalamotomy by a single surgeon were included. The procedure was performed as previously described, and patients were followed for up to 1 year. MRI was performed 24 h post-treatment, and lesion locations and volumes were calculated.
We retrospectively evaluated 118 essential tremor patients and five tremor-dominant Parkinson’s disease patients who underwent thalamotomy. At 24 h post-procedure, tremor abated completely in the treated hand in 81 essential tremor patients. Imbalance, sensory disturbances and dysarthria were the most frequent acute adverse events. Patients with any adverse event had significantly larger lesions, while inferolateral lesion margins were associated with a higher incidence of motor-related adverse events. Twenty-three lesions were identified with irregular tails, often extending into the internal capsule; 22 of these patients experienced at least one adverse event.
Treatment parameters and lesion characteristics changed with increasing surgeon experience. In later cases, treatments used higher maximum power (normalized to skull density ratio), accelerated more quickly to high power, and delivered energy over fewer sonications.
Larger lesions were correlated with a rapid rise in both power delivery and temperature, while increased oedema was associated with rapid rise in temperature and the maximum power delivered. Total energy and total power did not significantly affect lesion size. A support vector regression was trained to predict lesion size and confirmed the most valuable predictors of increased lesion size as higher maximum power, rapid rise to high-power delivery, and rapid rise to high tissue temperatures. These findings may relate to a decrease in the energy efficiency of the treatment, potentially due to changes in acoustic properties of skull and tissue at higher powers and temperatures.
We report the largest single surgeon series of focused ultrasound thalamotomy to date, demonstrating tremor relief and adverse events consistent with reported literature. Lesion location and volume impacted adverse events, and an irregular lesion tail was strongly associated with adverse events. High-power delivery early in the treatment course, rapid temperature rise, and maximum power were dominant predictors of lesion volume, while total power, total energy, maximum energy and maximum temperature did not improve prediction of lesion volume. These findings have critical implications for treatment planning in future patients.
Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia
Authors: Pasetto Laura , Grassano Maurizio , Pozzi Silvia , Luotti Silvia , Sammali Eliana , Migazzi Alice , Basso Manuela , Spagnolli Giovanni , Biasini Emiliano , Micotti Edoardo , Cerovic Milica , Carli Mirjana , Forloni Gianluigi , De Marco Giovanni , Manera Umberto , Moglia Cristina , Mora Gabriele , Traynor Bryan J , Chiò Adriano , Calvo Andrea , Bonetto Valentina 
Published: September 2021

Abstract
Aggregation and cytoplasmic mislocalization of TDP-43 are pathological hallmarks of amyotrophic lateral sclerosis and frontotemporal dementia spectrum. However, the molecular mechanism by which TDP-43 aggregates form and cause neurodegeneration remains poorly understood. Cyclophilin A, also known as peptidyl-prolyl cis-trans isomerase A (PPIA), is a foldase and molecular chaperone. We previously found that PPIA interacts with TDP-43 and governs some of its functions, and its deficiency accelerates disease in a mouse model of amyotrophic lateral sclerosis.
Here we characterized PPIA knock-out mice throughout their lifespan and found that they develop a neurodegenerative disease with key behavioural features of frontotemporal dementia, marked TDP-43 pathology and late-onset motor dysfunction.
In the mouse brain, deficient PPIA induces mislocalization and aggregation of the GTP-binding nuclear protein Ran, a PPIA interactor and a master regulator of nucleocytoplasmic transport, also for TDP-43. Moreover, in absence of PPIA, TDP-43 autoregulation is perturbed and TDP-43 and proteins involved in synaptic function are downregulated, leading to impairment of synaptic plasticity. Finally, we found that PPIA was downregulated in several patients with amyotrophic lateral sclerosis and amyotrophic lateral sclerosis-frontotemporal dementia, and identified a PPIA loss-of-function mutation in a patient with sporadic amyotrophic lateral sclerosis . The mutant PPIA has low stability, altered structure and impaired interaction with TDP-43.
These findings strongly implicate that defective PPIA function causes TDP-43 mislocalization and dysfunction and should be considered in future therapeutic approaches.