bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH PUPUK NPK DAN NANO PESTISIDA SERAIWANGI TERHADAP PERTUMBUHAN DAN HASIL TANAMAN CABAI MERAH (Capsicum annuum L.)
Authors: Ernita Milda , Alhidayati Alhidayati , Haryoko Widodo 
Published: April 2021

Experiments on the influence of NPK fertilizers and citronella pesticides nano on the growth and yield of red chili (Capsimum annuum L.) were carried out on dry land in Korong Pasar Baru village, Nansabaris District, Padang Pariaman Regency, West Sumatra from February - June 2020. The research objective was to determine the interaction of NPK fertilizer and citronella pesticide on growth, yield and disease attack rates in red chilies. The experiment used a randomized block design (RBD) with two factors. The first factor was the dosage of NPK fertilizer consisting of 3 levels, namely: 0 kg/ha, 100 kg/ha, and 150 kg/ha. The second factor is the concentration of citronella pesticide nano, namely: 0 ml/L, 3 ml/L, 6 ml/L and 9 ml/L. Based on the results of the experiment, it can be concluded that NPK fertilizers and citronella pesticides can increase the growth and yield of chili plants and suppress curly disease 83.4%.
STRATEGI PENGELOLAAN HUTAN RAKYAT DI KABUPATEN LUWU UTARA
Authors: A. Kaisang Salma , Nuraeni Nuraeni , Subaedah St 
Published: April 2021

People forest in North Luwu regency has a large enough potential but has not been managed intensively. The purpose of this research : reviewing people forest management in North Luwu regency, identifying internal and external factors in people forest management and formulate people forest management strategies in North Luwu regency. This research was conducted in North Luwu regency with a survey method in three dictricts, the sample was taken randomly with a total of 47 respondents. Data analysis was performed using descriptive methods and SWOT analysis. The result of the analyses indicated that the strategy could be best applied was strength-opportunity (SO) strategy, namely by (1) land optimization by developing agroforestry systems to increase land productivity by planting MPTS ( Multipurpose Tree Species) plants and the same time minimizing erosion, (2) increase the institutional capacity of forest farmer groups (KTH), and (3) inventory of existing potential to regulate planting and production in order to ensure the sustainability of people forest.
Історія музею Харківського національного університету Повітряних Сил України імені Івана Кожедуба
Authors: Чечин О.А. 
Published: April 2021

У статті розглянуто історію музею Харківського національного університету Повітряних Сил імені Івана Кожедуба. Висвітлюється концепція музею, іі витоки та форми реалізації. Окрема увага приділена інноваційним рішенням і використанню сучасних інформаційних технологій у музейній справі. Окреслені перспективи розвитку музею. Запропонована модель єдиного інформаційного простору для військових музеїв.
Ключові слова: історія, музей, аналіз, концепція, інновації, мультимедіа, інтерактивність, QR-код, контент, система.
Serum Potassium and Angiographic Severity of Coronary Artery Disease in Non-ST Elevation Myocardial Infarction
Authors: Sultana Maimuna , Rahman Afzalur , Karmakar Pradip Kumar , Islam AKM Monwarul , Mamun Al , Siddika Khondaker Aisha , Anwar Kazi Md Rubayet , Datta Gokul Chandra , Debnath Deb Dulal , Chowdhury Shaikat , Islam Md Nazmul 
Published: April 2021

Background: Non-ST elevation myocardial infarction (NSTEMI) patients like other patients with acute coronary syndrome (ACS) need assessment of severity of coronary artery disease (CAD) for prognostication and management. The available scoring systems are complex and include invasive parameters. On the other hand, potassium is a key element and its blood level has been shown to reflect health and disease of vasculature including in some ACS.
Objective: The study was conducted to find out the relationship between serum potassium level and angiographic severity of CAD in NSTEMI.
Method: A total of 200 cases of NSTEMI patients undergoing coronary angiography (CAG) were included. Patients getting medications that alter potassium homeostasis (e.g., diuretics, glucocorticoids, intravenous insulin), having renal impairment, haematological or liver disease, congenital or valvular heart disease, cardiomyopathy, prior percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) were excluded. Serum potassium was measured soon after admission with NSTEMI, and the patients were divided: mid to high normal (4 to 5.5 mmol/L) constituted the group I and low normal (3.5-3.9 mmol/L) constituted the group II. CAG was done during index admission, SYNTAX score calculated and compared between 2 groups. Results: High SYNTAX score was significantly more commonly found in group I than in group II (62.1% vs. 14.7%, p<0.001). Mean SYNTAX score was higher in group I than in group II (24.3±8.2 vs. 15.3±7.8, p<0.001). There was a linear relationship between serum potassium level and SYNTAX score. Mid to high normal serum potassium, hypertension and dyslipidemia were found to be significantly related to higher SYNTAX score with odds ratio being 10.44, 4.37 and 2.12 respectively.
Conclusions: Within physiological limits, higher serum potassium level correlates with severe coronary artery disease in NSTEMI patients. It may be used as an additional tool in conjunction with other scoring systems to assess the severity of CAD in this subset of ACS patients.
Bangladesh Heart Journal 2020; 35(2) : 128-133
Percutaneous Closure of Acquired Hole- First Case Report from Bangladesh
Authors: Haq Tawfiq Shahriar , Chowdhury Naharuma Aive Hyder , Khan Abdul Mazid , Hossain Jesmin , Malik Fazila Tun Nesa 
Published: April 2021

Rupture sinus of Valsalva (RSOV) is an uncommon condition with a wide spectrum of presentation, ranging from an asymptomatic murmur to cardiogenic shock or even sudden cardiac death. Our case presented at 62 yrs with progressive onset of dyspnea, palpitation with deterioration of exercise capacity. Diagnosis of ruptured sinus of Valsalva was made by echocardiography, it was aneurysmal and opened into right ventricular outflow tract. Coronary artery disease was excluded by coronary angiogram. Probable cause of rupture was atherosclerosis.We closed percutaneously with ADO I device. The procedure was completed uneventfully. Patient discharged with duel antiplatelet and is on follow up.
Bangladesh Heart Journal 2020; 35(2) : 155-158
PENGARUH DEBT TO EQUITY RATIO (DER) DAN EARNING PER SHARE (EPS) TERHADAP HARGA SAHAM (STUDI KASUS PADA PERUSAHAAN SUB SEKTOR PERTAMBANGAN BATUBARA YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE TAHUN 2014 – 2019)
Authors: Budiyani Putri Asri , Dailibas Dailibas 
Published: April 2021

The development of the coal mining subsector companies have decreased, especially in stock prices. The companies performance is the main point for investors to invest in the middle of a less good level influenced by various factors, including due to debt and profit. Financial statements are a proof of the companies performance. Searching for these factors is done by analyzing financial ratios related to debt and profits. The purpose of this research is analyze whether DER and EPS have a partial and simultaneous effect on stock prices. The population are all coal mining subsector companies listed on the Indonesia Stock Exchange (BEI) in the period 2014-2019 with a sample of 10 companies. This research is quantitative with purposive sampling technique. The data used are financial statements published by the Indonesia Stock Exchange (BEI) and then processed using SPSS for Windows 25. The results of the research get that partially DER has no effect on stock prices while EPS has an effect on stock prices. Simultaneously the DER and EPS have effects together on stock prices. Based on the results of DER and EPS with regression models, the variables have a strong influence on stock prices with determination were 37%. The biggest influence was contributed is EPS by 31% and then DER by 6%.
PELAKSANAAN PUTUSAN PENGADILAN AGAMA MENGENAI TANGJUNG JAWAB AYAH TERHADAP BIAYA PEMELIHARAAN SETELAH PERCERAIAN
Authors: Amrudi Amrudi 
Published: April 2021

Islam adalah sebuah agama yang berbentuk sebuah peraturan hidup yang menjadi sumber rahmat dan kebahagiaan bagi seluruh kaum muslim. Manusia diturunkan bersama dengan peratuaran hidupnya agar tidak terjadi benturan dan ketidakseimbangan. Bantuan dan ketidakseimbangan ada ketika manusia mulai mencampakkan islam sebagai peraturan dalam hidupnya. Perkawinan merupakan salah satu perintah agama kepada yang mampu untuk segera melaksanakannya. Karena perkawinan dapat mengurangi kemaksiatan, baik dalam bentuk penglihatan maupun dalam bentuk perzinaan. Orang yang berkeinginan untuk melakukan pernikahan, tetapi belum mempunyai persiapan bekal (fisik dan nonfisik) dianjurkan Oleh Nabi Muhammad SAW, untuk berpuasa. Orang berpuasa akan memiliki kekuatan atau penghalang dari berbuat tercela yang sangat keji, yaitu perzinaan. Keluarga harus terbentuk dari pondasi yang kokoh. Pondasi tersebut adalah akidah islam, ikatan atas dasar keutamaan agama (dien). Dengan niat, cara, peroses pernikahan yang sesuai dengan syariat islam, maka restu akan menjadi doa dari semua yang menyaksikan ikatan tersebut. Maka sakinah, mawaddah, warohmah muda dicapai.
Kesimpulan Penelitian ini Bahwa anak yang belum berumur 12 tahun (mumayyiz) dibawah pengasuhan ibunya, bahwa biaya pengasuhan anak di tetapkan Rp.1.000.000.00 perbulan ditentukan karenakan mantan suami memiliki hutang pada pihak lain walaupun pengahsilan kurang dari Rp 4.000.000.00. Bahwa untuk mendapatkan sentuhan kasih sayang dari kedua orang tua yang bercerai diberi hak keduanya memberikan perhatian kasih sayang masing-masing sesuai punsinya, ibu merawat dan ayah memberi mafkah hidup. Dalam kata lain si ibu tidak berhak memonopolo pengasuhan anak tanpa memberikan kesempatan pada ayahnya.
KEPUASAN PASIEN ANC DAN IMMUNISASI TERHADAP PENERAPAN APLIKASI PENDAFTARAN ONLINE BERBASIS ANDROID
Authors: Suryandari Endang Sri Dewi Hastuti 
Published: April 2021

Pelayanan pendaftaran di BPM (Bidan Praktik Mandiri) Ovalya Makarova Kecamatan Pujon masih dilakukan secara manual yaitu dengan menggunakan buku register dan buku KIA pasien. Hal ini menyebabkan pasien menunggu antrian untuk mendapatkan pelayanan. Tujuan dari penelitian ini adalah untuk mengetahui tingkat kepuasan pasien dalam menggunakan aplikasi pendaftaran online berbasis android di BPM Ovalya Makarova Kecamatan Pujon. Rancangan penelitian ini menggunakan Research and Development (R&D), dengan metode penelitian survei deskriptif. Variabel dari penelitian ini adalah aplikasi pendaftaran online berbasis android dan tingkat kepuasan pasien. Subjek penelitian adalah ibu hamil yang memeriksakan kehamilan (antenatal care) ataupun yang datang untuk mengimunisasikan bayi/balitanya sejumlah 59 pasien. Peneliti menggunakan bahasa pemrograman PHP dan HTML dengan menggunakan database MySQL untuk merancang aplikasi. Hasil dari uji fungsi aplikasi menggunakan uji blackbox adalah semua fungsi menu dan item aplikasi dinyatakan valid, sehingga aplikasi layak untuk digunakan. Edukasi telah dilakukan kepada pasien khususnya pasien imunisasi dan antenatal care. Hasil dari implementasi aplikasi pendaftaran online berbasis android dengan menggunakan kuesioner kepuasan didapatkan rata-rata skor 3,01 yang berarti bahwa pasien menyatakan puas dalam menggunakan aplikasi. Maka dapat disimpulkan bahwa aplikasi pendaftaran online berbasis android dapat mempermudah pasien dalam melakukan proses pendaftaran di BPM Ovalya Makarova Kecamatan Pujon. Perlunya perbaikan dan pengembangan aplikasi yang dapat dilakukan oleh peneliti lain, seperti menu tambahan pada aplikasi pendaftaran online berbasis android.
Pengetahuan Keluarga Pasien Tuberkulosis Sebagai Upaya Penyembuhan dan Penurunan Angka Kejadian Tuberkulosis
Authors: Sumiati Eti 
Published: April 2021

Tuberculosis is an infectious disease of the respiratory tract and other organs caused by the Mycobacterium tuberculosis bacteria. Tuberculosis (TB) is still one of the causes of high morbidity and mortality in the world. Indonesia is among the five countries with the highest incidence of cases. Patient adherence to medication is an important factor in the success of a treatment, and will increase the overall cure rate. The cure rate for TB patients can be influenced by several things, which one is family support, so that family knowledge of TB disease experienced by patients is very important. The aimed of this research to know the description of the patient's family knowledge about tuberculosis. This research is descriptive using data collection tools in the form of questionnaires as primary data and patient medication cards as secondary data using convenience sampling method. The subjects in the study were family members of pulmonary and extrapulmonary tuberculosis patients without complications and without MDR who were undergoing treatment for the period January-March 2019 at the Kediri Public Health Center. The results showed that as many as 11 respondents had high / good knowledge and as many as 9 respondents had low/poor knowledge.
Profil Karakteristik Individu Terhadap Kejadian Hiperuresemia
Authors: Arsa Putu Sintya Arlinda 
Published: April 2021

Abstrak
Pendahuluan Hiperuresemia merupakan peningkatan kadar asam urat pada darah. Prevalensi hiperuresemia mengalami peningkatan. Gout merupakan gangguan metabolik yang ditandai dengan peningkatan kadar asam urat (hiperuresemia). Hiperuresemia jika tidak ditangani dengan tepat maka dapat dapat mengancam nyawa manusia. Tujuan dari penelitian ini adalah mengetahui gambaran kejadian hiperuresemia pada warga di RT 02 RW 03 Kelurahan Arjosari Kecamatan Blimbing Kota Malang. Data yang diteliti adalah jenis kelamin, usia, pendidikan, pekerjaan dan pendapatan. Metode penelitian yang digunakan design penelitian observasi analitik cross sectional, pengambilan data dilakukan dengan wawancara dan pengukuran kadar asam urat dalam darah melalui metode test stick kadar asam urat darah. Teknik pengambilan sampel menggunakan Simple Random Sampling dengan jumlah sampel 50 responden. Hasil penelitian didapatkan karakteristik responden berdasarkan jenis kelamin perempuan lebih besar 68,4 %, karakteristik usia sebagian besar berusia 50-59 tahun dengan persentase 42,1%, karakteristik responden berdasarkan pendidikan berasal jenjang perguruan tinggi sebesar 36,8 %, karakteristik responden berdasarkan jenis pekerjaan sebagian besar tidak bekerja/IRT sebesar 52,6% dan karakteristik responden berdasarkan pendapatan sebesar >2.000.000 perbulan dengan persentase 42,1 %. Kesimpulan Hasil penelitian ini diharapkan mampu dijadikan kebijakan kesehatan masyarakat untuk selalu menerapkan pola makan yang sehat, diet rendah purin, dan rutin berolahraga.

Kata Kunci: Hiperuresemia; Asam urat; Karakteristik individu
Identification of Novel Biomarkers for Pre-diabetic Diagnosis Using a Combinational Approach
Authors: Yang Meng-Ting , Chang Wei-Hung , Kuo Tien-Fen , Shen Ming-Yi , Yang Chu-Wen , Tien Yin-Jing , Lai Bun-Yueh , Chen Yet-Ran , Chang Yi-Cheng , Yang Wen-Chin 
Published: April 2021

Reliable protein markers for pre-diabetes in humans are not clinically available. In order to identify novel and reliable protein markers for pre-diabetes in humans, healthy volunteers and patients diagnosed with pre-diabetes and stroke were recruited for blood collection. Blood samples were collected from healthy and pre-diabetic subjects 12 h after fasting. BMI was calculated from body weight and height. Fasting blood glucose (FBG), glycated hemoglobin (HbA1C), triglyceride (TG), total cholesterol, high-density lipoprotein, low-density lipoprotein (LDL), insulin and albumin were assayed by automated clinical laboratory methods. We used a quantitative proteomics approach to identify 1074 proteins from the sera of pre-diabetic and healthy subjects. Among them, 500 proteins were then selected using Mascot analysis scores. Further, 70 out of 500 proteins were selected via volcano plot analysis according to their statistical significance and average relative protein ratio. Eventually, 7 serum proteins were singled out as candidate markers for pre-diabetes due to their diabetic relevance and statistical significance. Immunoblotting data demonstrated that laminin subunit alpha 2 (LAMA2), mixed-lineage leukemia 4 (MLL4), and plexin domain containing 2 (PLXDC2) were expressed in pre-diabetic patients but not healthy volunteers. Receiver operating characteristic curve analysis indicated that the combination of the three proteins has greater diagnostic efficacy than any individual protein. Thus, LAMA2, MLL4 and PLXDC2 are novel and reliable serum protein markers for pre-diabetic diagnosis in humans.
TGFβ1: An Indicator for Tumor Immune Microenvironment of Colon Cancer From a Comprehensive Analysis of TCGA
Authors: Wang Jinyan , Wang Jinqiu , Gu Quan , Yang Yan , Ma Yajun , Zhang Quan’an 
Published: April 2021

BackgroundTumor microenvironment (TME) and tumor-infiltrating immune cells (TICs) greatly participate in the genesis and development of colon cancer (CC). However, there is little research exploring the dynamic modulation of TME.MethodsWe analyzed the proportion of immune/stromal component and TICs in the TME of 473 CC samples and 41 normal samples from The Cancer Genome Atlas (TCGA) database through ESTIMATE and CIBERSORT algorithms. Correlation analysis was conducted to evaluate the association between immune/stromal component in the TME and clinicopathological characteristics of CC patients. The difference analysis was performed to obtain the differentially expressed genes (DEGs). These DEGs were further analyzed by GO and KEGG enrichment analyses, PPI network, and COX regression analysis. Transforming growth factor β1 (TGFβ1) was finally overlapped from the above analysis. Paired analysis and GSEA were carried out to understand the role of TGFβ1 in colon cancer. The intersection between the difference analysis and correlation analysis was conducted to learn the association between TGFβ1 and TICs.ResultsOur results showed that the immune component in the TME was negatively related with the stages of CC. GO and KEGG enrichment analysis revealed that 1,110 DEGs obtained from the difference analysis were mainly enriched in immune-related activities. The intersection analysis between PPI network and COX regression analysis indicated that TGFβ1 was significantly associated with the communication of genes in the PPI network and the survival of CC patients. In addition, TGFβ1 was up-regulated in the tumor samples and significantly related with poor prognosis of CC patients. Further GSEA suggested that genes in the TGFβ1 up-regulated group were enriched in immune-related activities and the function of TGFβ1 might depend on the communications with TICs, including T cells CD4 naïve and T cells regulatory.ConclusionThe expression of TGFβ1 might be an indicator for the tumor immune microenvironment of CC and serve as a prognostic factor. Drugs targeting TGFβ1 might be a potential immunotherapy for CC patients in the future.
Association of Serum Immunoglobulins Levels With Specific Disease Phenotypes of Crohn's Disease: A Multicenter Analysis in China
Authors: Song Dong Juan , Shen Jun , Chen Min Hu , Liu Zhan Ju , Cao Qian , Hu Pin Jin , Gao Xiang , Qian Jia Ming , Wu Kai Chun , Lai Li Jie , Ran Zhi Hua 
Published: April 2021

Background and Aim:Serum immunoglobulins were reported to be associated with clinical characteristics of inflammatory bowel disease. However, whether a difference exists in the serum immunoglobulins levels in patients with Crohn's disease (CD) with different disease location and behavior phenotypes remains unclear. Therefore, this study aimed to explore the associations of serum immunoglobulins levels with specific CD phenotypes.Methods:Patients with CD having recorded serum immunoglobulins levels were recruited through multicenter collaborative efforts. The associations between serum immunoglobulins levels and distinct phenotypes of CD were evaluated using multiple logistic regression models.Results:A total of 608 patients with CD were included in the study. Elevated (above the upper limit of normal) serum immunoglobulin G (IgG), IgA, IgM, and IgG4 were identified in 24.5, 17.4, 2.1, and 8.2% of patients, respectively. Elevated serum IgG4 levels negatively correlated with complicated disease behavior [odds ratio (OR) 0.49, 95% confidence interval (CI) 0.26–0.92]. Elevated serum IgG was linked to isolated ileal disease with an OR of 0.37 (95% CI 0.23–0.61). The ORs of isolated ileal disease progressively reduced across increasing quartiles of IgG (Pfor trend &lt; 0.001). The adjusted ORs of isolated ileal disease for increasing quartiles of IgM were 1.82 (1.07–3.1), 1.92 (1.14–3.24), 1.17 (0.69–1.98), and 1 (Pfor trend = 0.008). Besides, serum IgA and IgG levels significantly correlated with several disease activity indices.Conclusions:These results suggested that certain serum immunoglobulins were associated with specific disease phenotypes of CD. Further investigations to account for the associations are warranted.
Family Planning Decision Making in People With Multiple Sclerosis
Authors: Bonavita Simona , Lavorgna Luigi , Worton Hilary , Russell Susan , Jack Dominic 
Published: April 2021

Introduction: The majority of people diagnosed with MS are of childbearing or child fathering age, therefore family planning is an important issue for both women and men with MS. Fertility and the course of pregnancy are not affected by MS; however, people with MS (pwMS) may have concerns that there will be a greater risk of complications to the mother and/or adverse pregnancy outcomes either due to the disease or to ongoing medication. This survey aimed to understand family planning decision making in pwMS and related unmet educational needs.Methods: A total of 332 pwMS across the USA, UK, France, Germany, Italy, and Spain were recruited from a specialist patient panel agency to participate in a smartphone-enabled standing panel. The 80-question survey focussed on decision making and information sources for pwMS regarding family planning, as well as behavior during and after pregnancy. Male patients with MS did not respond to specific questions on pregnancy. Survey results were directly compared with the 2016 US and 2010 UN census data.Results: pwMS were more likely to have no children than the general population, particularly in the subgroup of patients aged 36–45 years. A total of 56% of pwMS reported that the disease affected, with different degrees of impact, their family planning decision making. Of these, 21% significantly changed their plans for timing of pregnancy and the number of children, and 14% decided against having children. Participants indicated that healthcare professionals were the primary source of information on family planning (81% of responses). The timing of planned pregnancy was not considered when selecting treatment by 78% of participants.Conclusion: MS was found to significantly impact family planning decision making, with pwMS significantly less likely to have children in comparison with the general population.