bluuebunny/crossref_metadata_2025_split huggingface dataset:
One- and Multi-dimensional CWENOZ Reconstructions for Implementing Boundary Conditions Without Ghost Cells
Authors: Semplice M. , Travaglia E. , Puppo G. 
Published: October 2021

AbstractWe address the issue of point value reconstructions from cell averages in the context of third-order finite volume schemes, focusing in particular on the cells close to the boundaries of the domain. In fact, most techniques in the literature rely on the creation of ghost cells outside the boundary and on some form of extrapolation from the inside that, taking into account the boundary conditions, fills the ghost cells with appropriate values, so that a standard reconstruction can be applied also in the boundary cells. In Naumann et al. (Appl. Math. Comput. 325: 252–270. https://doi.org/10.1016/j.amc.2017.12.041, 2018), motivated by the difficulty of choosing appropriate boundary conditions at the internal nodes of a network, a different technique was explored that avoids the use of ghost cells, but instead employs for the boundary cells a different stencil, biased towards the interior of the domain. In this paper, extending that approach, which does not make use of ghost cells, we propose a more accurate reconstruction for the one-dimensional case and a two-dimensional one for Cartesian grids. In several numerical tests, we compare the novel reconstruction with the standard approach using ghost cells.
Patient Characteristics and Clinical and Intraoperative Variables Affecting Outcome in Pediatric Traumatic Brain Injury
Authors: Dhanda Ankur , Bindra Ashish , Dhakal Roshni , Chavali Siddharth , Singh Gyaninder P. , Singh Pankaj K. , Mathur Purva 
Published: October 2021

Abstract
Background Pediatric traumatic brain injury (TBI) has distinctive pathophysiology and characteristics that differ from adults. These can be attributed to age-related anatomical and physiological differences and distinct patterns of injuries seen in children. Our aim was to identify the patient characteristics, clinical variables during intensive care and intraoperative management associated with poor functional outcome in a cohort of pediatric TBI patients.
Methods Retrospective chart review of pediatric TBI patients admitted to neurotrauma intensive care unit (NICU) over a period of 1 year.
Results A total of 105 children (< 12 years) with head injury were admitted in the NICU during the study period. The most common mechanism of injury was fall in 78% cases. Fifty-four patients (51.4%) presented with a severe head injury (Glasgow coma scale [GCS] ≤ 8), while 31 (29.5%) and 20 (19.1%) had a mild and moderate head injury. The most common finding was skull fractures (59%), contusions (36.2%), and subdural hematoma (SDH) (30.4%). Forty nine patients (46.7%) required surgical management. The median duration of anesthesia was 205 (interquartile range [IQR] 65, 375) minutes, and median blood loss during the surgery was 16.7 mL/kg body weight with 41% requiring intraoperative blood transfusions. Median duration of ICU and hospital stay was 5 (IQR 1, 47) and 8 (IQR 1, 123) days, respectively. GOS at discharge ≤ 3 representing poor outcome was present in 35 patients (33.3%). Mortality was seen in 15 (14.3%) patients. Multivariate analysis identified postresuscitation GCS ≤ 8 on admission as independent predictor of mortality, and postresuscitation GCS ≤ 8 on admission and NICU stay of > 7 days as independent predictor of poor outcome.
Conclusion Despite advances in neurointensive care, mortality and morbidity remains high in pediatric head trauma and is mainly dependent on postresuscitation GCS and NICU stay of more than 7 days. Multidimensional approach is required for its prevention and management.
Clinical Application of Platelet-Rich Fibrin in Pediatric Dentistry
Authors: Gunasekaran Sowndarya , Sakthivel Soundarya , M. Shanthala B. , Babu George , Vijayan Vidhya 
Published: October 2021

AbstractPlatelet-rich fibrin (PRF) is a fibrin matrix in which platelet cytokines, growth factors, and cells are trapped and may be released after a certain time and that can serve as a resorbable membrane. It can be obtained from blood with the help of a simple process. PRF is basically a concentrate of growth factors that promote wound healing and regeneration, which is used in various disciplines of dentistry to repair various lesions and regenerate dental and oral tissues. Although the use of PRF is well-documented, its use in pediatric dentistry remains unexplored, due to its restrictions and on account of the fact that it is a blood-derived product. PRF has been used globally to enhance tissue healing. This article provides an insight into the use of PRF in pediatric dentistry, its benefits, limitations, and recommendations.
Estimation of Sexual Dimorphism of the Mandible in Coastal Karnataka and Kerala Populations using Cone Beam Computed Tomography
Authors: Rao Kumuda , Shetty Mahabalesh , Nayak U. S. Krishna , Babu G. Subhas , Shetty D. Prashanth , Shetty Prajwal K. 
Published: October 2021

Abstract
Objective The mandible has been used for sex determination and forensic identification due to its unique anatomy and morphology. Every part of the mandible is unique, including the shape and size of the temperomandibular joint, the ramus, the body and the symphysis region, and the inferior alveolar canal. In addition, the position and placement of the teeth within their sockets are unique for every individual.
Sample Population A study was conducted on 20 males and females to estimate sexual dimorphism using anthropometric measurements obtained by cone beam computed tomography images of the mandible of Karnataka and Kerala populations.
Materials and Methods The mean, standard deviation, and standard error along with the confidence interval of different measurements were documented. Various measurements between the sexes were compared using Student's t-test. Association between categorical variables was analyzed using the Chi-square test. A p-value < 0.05 was considered to be statistically significant. Data were analyzed using statistical SPSS software.
Results The p-value of mRBr L, GA L, and GA R among females was significantly higher in the Karnataka population when compared with that in the Kerala population. The Karnataka State population showed significantly higher values of RL R, BiGBr, and BiCBr among males, and the p-value of the Kerala population for GGL L and GGL R was significant and higher among the males.
Conclusion The data derived from the above study suggest that the mandibular anthropometric measurements used may be applied for forensic sex estimation.
A Study on the Effect of Valeric Acid in Alzheimer's Induced Rats by the Estimation of Aβ 1-42 Biomarker
Authors: Dulla Blessina Sugandhi , S. Bindhu , K. Leena Pramod 
Published: October 2021

AbstractThe effect of valeric acid on the behavior of Alzheimer's disease (AD)-induced rats by aluminum chloride (100 mg/kg body weight) was assessed using elevated plus maze (EPM) and the Hebb Williams maze (HWM). Amyloid β 1–42(Aβ1–42) biomarker was estimated by ELISA. In this study, valeric acid-treated rats were compared with those treated with piracetam (200 mg/kg), rivastigmine (0.5 mg/kg), and the results showed the rats treated with valeric acid had a very less transfer latency of EPM and HWM when compared with other standard drugs. In addition, valeric acid-treated rats showed reduced levels of amyloid β1–42 biomarker in the plasma. Hence, this study found that valeric acid may be suggested as a better drug for Alzheimer's disease.
Autism and Emotion: A Narrative Review
Authors: Kanagaraj Sagayaraj , Devishrree S. , Swetha J. , Priya B. Krishna , Sankar Srivarshini , Cherian Jincy , Gopal C.N. Ram , Karthikeyan S. 
Published: October 2021

AbstractAutism spectrum disorder (ASD) includes a variety of childhood-onset and lifelong neurodevelopmental condition with an enduring impact on multiple domains of functioning characterized by persistent deficits in social communication, restricted and repetitive behavior interest, and activities. They often find it hard to recognize and control emotions but their emotional expression can be improved by various intervention techniques that in turn can help them understand and respond more appropriately to other people. Problems in the area on emotional reciprocity among individual with ASD involve recognizing, understanding, expressing, and regulating emotions. Their ability in emotional reciprocity is often improved with a comprehensive treatment approach, especially by focused emotional enhancement intervention. In this review, we followed the standard IMRAD (Introduction, Methods, Results, and Discussion) structure to critically examine the condition of autism and its relation with genetic mechanism, and how theories of emotion and theory of mind associated with persons with ASD, some of the widely used assessment tools and future research direction in the emotional development of individuals diagnosed with ASD by using the narrative review method. Records collected through research databases such as Scopus, PubMed, Web of Science, Medline, EBSCO and published books with ISBN (International Standard Book Number), and published test manuals were evaluated in-depth and summarized based on the subtopic of the proposed title. A critical theoretical analysis of the genetic mechanism of emotions, theories of emotions, and theory of mind was explained in connection with ASD.
Compliance of Diabetic Clients: Effect of Nurse-Led Home Care Interventions and Monitoring
Authors: Leena K. C. , Alvares Irene , Sequeira Sonia Karen Liz , Pereira Priya Sweety , Deepika N. C. , Sequeira Hazel Asha 
Published: October 2021

Abstract
Objectives Type 2 diabetes impacts greatly on quality of life. Health-care providers must focus on efforts to detect, treat, and manage clients through supportive educative approach. This study aims to measure effectiveness of nurse-led home care interventions.
Materials and Methods This study among 103 diabetic subjects measured baseline blood pressure (BP), weight, and blood glucose levels. Information on compliance was obtained using a rating scale consisting of domains: dietary habits, exercise, rest, sleep, symptom management, prevention of complications, medication, and follow-up. Individualized comprehensive nursing interventions (education, testing, counselling) were provided, that were reinforced two times a week for 4 weeks, with minimum 7 home visits carried out by the researchers who are registered nurses and teaching faculty along with six interns of BSc nursing program. Post-tests were obtained at second and fourth weeks after start of intervention.
Results Significant improvement in blood sugar (p < 0.05), systolic BP (p < 0.001), and diastolic BP (p < 0.001) was observed. There was no change in body mass index (BMI) (p > 0.05). Post-hoc analysis found significant difference between pre-, post1- and post2-measures. Significant association was found between dietary habits and BMI (p < 0.05) and diastolic BP (p < 0.05). Compliance improved from 29 (28.2%) to 47(45.6%), partially compliant from 55 (53.4%) to 45 (43.7%) and noncompliant 19 (18.4%) to 11 (10.7%), with a clear improvement in each of the domains of compliance.
Conclusion Individualized comprehensive interventions delivered at the natural environment of families by registered nurses effectively improve compliance to diabetes management.
Vitamin D Supplementation in Sarcoidosis: A Double-Edged Sword
Authors: Chandran Rishikesh , Nagendra Lakshmi , Acharya Shrikrishna , Hosmane Giridhar Belur , Shetty Vijith , Kellarai Adithi , KR Bhagavan 
Published: October 2021

AbstractSarcoidosis is complicated by disordered vitamin D and calcium metabolism, which has important implications on disease activity and bone health. Although the majority of the patients with sarcoidosis are typically deficient in 25-hydroxyvitamin D, repletion of vitamin D is controversial in light of the hypercalcemia risk. Presently, there are no clear guidelines regarding vitamin D supplementation as a part of osteoporosis prevention in patients with vitamin D deficiency and sarcoidosis. We report a patient with sarcoidosis who presented with severe hypercalcemia following vitamin D supplementation and review the debated role of vitamin D supplementation in vitamin D-deficient sarcoid patients.
Dissection of TAF1 neuronal splicing and implications for neurodegeneration in X-linked dystonia-parkinsonism
Authors: Capponi Simona , Stöffler Nadja , Penney Ellen B , Grütz Karen , Nizamuddin Sheikh , Vermunt Marit W , Castelijns Bas , Fernandez-Cerado Cara , Legarda G Paul , Velasco-Andrada M Salvie , Muñoz Edwin L , Ang Mark A , Diesta Cid Czarina E , Creyghton Menno P , Klein Christine , Bragg D Cristopher , De Rijk Peter , Timmers H T Marc 
Published: October 2021

Abstract
X-linked dystonia-parkinsonism (XDP) is a monogenic neurodegenerative disorder of the basal ganglia, which presents as a combination of hyperkinetic movements and parkinsonian features. The underlying genetic mechanism involves the insertion of a SINE-VNTR-Alu retrotransposon within the TAF1 gene. Interestingly, alterations of TAF1 have been involved in multiple neurological diseases. In XDP, the SINE-VNTR-Alu insertion in TAF1 has been proposed to result in alternative splicing defects, including the decreased incorporation of a neuron-specific microexon annotated as 34′. This mechanism has become controversial as recent studies failed to provide support. In order to resolve this conundrum, we examined the alternative splicing patterns of TAF1 mRNAs in XDP and control brains. The impact of the disease-associated SINE-VNTR-Alu on alternative splicing of microexon 34′ was further investigated in cellular assays. Subsequently, microexon 34′ incorporation was explored by RT-PCR and Nanopore long-read sequencing of TAF1 mRNAs from XDP and control brains tissues. Using cell-based splicing assays, we demonstrate that presence of the disease-associated SINE-VNTR-Alu does not affect the inclusion of microexon 34′. In addition, we show that (1) microexon 34′-containing TAF1 mRNAs are detected at similar levels in XDP as in controls and that (2) the architecture of TAF1 transcripts is remarkably similar between XDP and controls brains. These results indicate that microexon 34′ incorporation into TAF1 mRNA is not affected in XDP brains. Our findings shift the current paradigm of XDP by discounting alternative splicing of TAF1 microexon 34′ as the molecular basis for this disease.
Deciphering glial scar after spinal cord injury
Authors: Zhang Yu , Yang Shuhai , Liu Chang , Han Xiaoxiao , Gu Xiaosong , Zhou Songlin 
Published: October 2021

AbstractSpinal cord injury (SCI) often leads to permanent disability, which is mainly caused by the loss of functional recovery. In this review, we aimed to investigate why the healing process is interrupted. One of the reasons for this interruption is the formation of a glial scar around the severely damaged tissue, which is usually covered by reactive glia, macrophages and fibroblasts. Aiming to clarify this issue, we summarize the latest research findings pertaining to scar formation, tissue repair, and the divergent roles of blood-derived monocytes/macrophages, ependymal cells, fibroblasts, microglia, oligodendrocyte progenitor cells (OPCs), neuron-glial antigen 2 (NG2) and astrocytes during the process of scar formation, and further analyse the contribution of these cells to scar formation. In addition, we recapitulate the development of therapeutic treatments targeting glial scar components. Altogether, we aim to present a comprehensive decoding of the glial scar and explore potential therapeutic strategies for improving functional recovery after SCI.
Chronology of Practice: Chinese Practice in Private International Law in 2020
Authors: Qisheng He 
Published: October 2021

Abstract
This survey contains materials reflecting the practice of Chinese private international law in 2020. First, regarding changes in the statutory framework of private international law in China, three legislative acts, one administrative regulation on the Unreliable Entity List and ten judicial interpretations of the Supreme People’s Court were adopted or amended in 2020 on a wide range of matters, including conflict of laws, punitive damages, international civil procedure, etc. Second, 11 typical cases involving Chinse courts’ jurisdiction are selected to highlight the development in Chinese private international law, involving standard essential patents, abuse of market dominance, declaration of non-infringement of patent, asymmetric choice of court agreement and other matters. Third, nine cases on choice of law questions relating, in particular, to habitual residence, rights in rem, matrimonial property regimes and ascertainment of foreign law, are examined. Fourth, five cases involving anti-suit injunction or anti-enforcement injunction are reported and one introduced in detail. Fifth, the first occasion for on international judicial assistance of extracting DNA, as well as three representative cases on the recognition and enforcement of foreign judgments, are discussed. The Statistics of international judicial assistance cases in China is first released in this survey. Finally, this survey also covers five recent decisions illustrating Chinese courts’ pro-arbitration attitude towards the uncertainty brought about by contractual clauses referring to both litigation and arbitration.
Influence of clinical and demographic factors on the oral health-related quality of life of patients with cleft lip and palate undergoing orthodontic treatment: a systematic review and meta-analysis
Authors: Nascimento Vanessa de Couto , Martins Mariana Martins e , Vilella Beatriz de Souza , Mattos Cláudia Trindade , Vilella Oswaldo de Vasconcellos 
Published: October 2021

Summary

Objective
The purpose of this study was to evaluate the influence of orthodontic treatment on the oral health-related quality of life (OHRQoL) of patients with cleft lip and palate.

Search methods
Electronic searches were conducted in Pubmed, Scopus, Web of Science, Cochrane Library, VHL, and OpenGrey databases, completed in January 2021.

Selection criteria
Cross-sectional and longitudinal observational studies that presented an assessment of OHRQoL in cleft patients undergoing orthodontic treatment were included, according to PRISMA guidelines. Contacts via email were made with authors, to clarify inaccuracies or request additional data.

Data collection and analysis
The entire process was accomplished by two authors, in case of disagreement, a third author mediated the discussion until there was a consensus. Risk assessment was performed by the Fowkes and Fulton qualifier, and the quality of evidence, assessed by the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) tool. A meta-analysis was performed considering the domains combined into three large groups (physical, psychological, and social). The questionnaires were standardized as to the scores and their direction.

Results
A total of 3822 studies were retrieved. After excluding duplicates, the titles and abstracts of the remaining articles were analysed. Twenty-eight articles were read in full; 13 met the eligibility criteria; 12 articles showed sufficient methodological quality and 7 were included in the quantitative assessment. The included studies were published between 2011 and 2019. The samples comprised 19 to 183 patients of both sexes. GRADE showed low evidence when compared to the control group, sexes, age, and types of cleft and very low evidence among longitudinal articles.

Conclusions
The OHRQoL is lower in orthodontic patients with cleft than in those without. The OHRQoL of patients with cleft undergoing orthodontic treatment is not influenced by gender or age group, considering children and adolescents, but it is influenced by the type of cleft. The OHRQoL of patients with CLP does not undergo significant changes during orthodontic treatment.

Limitations
The variety of instruments for measuring OHRQoL rendered meta-analysis difficult.

Registration
PROSPERO database number CRD42017054764.
Health literacy, pain-related interference and pain-related distress of patients with musculoskeletal pain
Authors: Bittencourt Juliana Valentim , de Souza Patrick Anderson Chaves , Corrêa Leticia Amaral , Volotão Andresa Narcizo , Mathieson Stephanie , Nogueira Leandro Alberto Calazans 
Published: October 2021

Summary
The present study aimed to compare pain-related interference and pain-related distress in patients with musculoskeletal pain and differing levels of health literacy. A cross-sectional study was conducted among 243 patients with chronic musculoskeletal pain. Short Test of Functional Health Literacy in Adults classified the level of health literacy. Outcome measures included pain-related interference (pain intensity and functional limitation) and pain-related distress (psychosocial factors). Analysis of variance methods were used. One hundred twenty-three (50.62%) participants were classified as adequate, 24 (9.88%) as marginal and 96 (39.50%) as inadequate health literacy. Patients with inadequate health literacy had higher values of pain severity compared to the other groups, when controlled for age. The group adequate health literacy showed less kinesiophobia compared to their counterparts. Functional limitations and other psychosocial factors were similar among groups. Pain severity and kinesiophobia had disadvantageous findings in participants with inadequate health literacy. Still, the results of pain severity must be approached cautiously because the differences were observed when controlled for age solely.
Recruitment in a research study via chatbot versus telephone outreach: a randomized trial at a minority-serving institution
Authors: Kim Yoo Jin , DeLisa Julie A , Chung Yu-Che , Shapiro Nancy L , Kolar Rajanna Subhash K , Barbour Edward , Loeb Jeffrey A , Turner Justin , Daley Susan , Skowlund John , Krishnan Jerry A 
Published: October 2021

Abstract
Chatbots are software applications to simulate a conversation with a person. The effectiveness of chatbots in facilitating the recruitment of study participants in research, specifically among racial and ethnic minorities, is unknown. The objective of this study is to compare a chatbot versus telephone-based recruitment in enrolling research participants from a predominantly minority patient population at an urban institution. We randomly allocated adults to receive either chatbot or telephone-based outreach regarding a study about vaccine hesitancy. The primary outcome was the proportion of participants who provided consent to participate in the study. In 935 participants, the proportion who answered contact attempts was significantly lower in the chatbot versus telephone group (absolute difference −21.8%; 95% confidence interval [CI] −27.0%, −16.5%; P &lt; 0.001). The consent rate was also significantly lower in the chatbot group (absolute difference −3.4%; 95% CI −5.7%, −1.1%; P = 0.004). However, among participants who answered a contact attempt, the difference in consent rates was not significant. In conclusion, the consent rate was lower with chatbot compared to telephone-based outreach. The difference in consent rates was due to a lower proportion of participants in the chatbot group who answered a contact attempt.