bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lack of Neutralization of 10-MDP Primers by Zirconia May Affect the Degree of Conversion of Dual-cure Resin Cement
Authors: De Paula DM , Loguercio AD , Reis A , Sauro S , Alves AH , Picanço PR , Yoshihara K , Feitosa VP 
Published: April 2021

Clinical Relevance
Use of zirconia primers with a low pH and a high acidic monomer concentration should be employed in combination with dual-cure resin cements that are less sensitive to an acidic environment. Primers with lower 10-MDP concentrations attain better outcomes.

SUMMARY

Objective:
To assess the effects of different concentrations of 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) included in experimental ceramic primers on the degree of conversion (DC) and microshear bond strength (μSBS) of a dual-cure resin cement, and on the acidity neutralization potential of zirconia (ZrO2) in comparison to hydroxyapatite (HAp).

Methods:
Experimental ceramic primers were formulated using 5 wt%, 10 wt%, 20 wt%, or 40 wt% 10-MDP as an acidic functional monomer and camphorquinone (CQ)/amine or 1-phenyl-1,2-propanedione (PPD) as a photoinitiator system. Clearfil Ceramic Primer (Kuraray Dental, Tokyo, Japan) was used as the commercial control. Micro-Raman spectroscopy was used to assess the DC of uncured and light-cured resin cements applied onto primer-treated ZrO2 surfaces. The μSBS and pH of primers were assayed in a universal testing machine and by a digital pH meter (Tec-3MP; Tecnal, Piracicaba, Brazil), respectively. Statistical analysis was performed by one-way analysis of variance (ANOVA) and Tukey’s test (p&lt;0.05).

Results:
DC was not affected until a concentration of 10% 10-MDP in CQ primer and 5% 10-MDP in PPD primer was reached, when compared with the positive control (p&gt;0.05). Groups 10-MDP 5% in CQ and PPD primers showed the highest μSBS compared with the positive control (p&gt;0.05); however, higher concentrations of 10-MDP induced significant DC and μSBS reduction (p&lt;0.05). HAp neutralized 10-MDP primers, but ZrO2 provided higher acidity to the primers’ pH.

Conclusion:
10-MDP monomer should be used in low concentrations in ZrO2 primers to avoid reduction of the polymerization and bond strength of resin cement.
Performance of a Universal Bonding System Associated With 2% Digluconate Chlorhexidine in Carious and Eroded Dentin
Authors: Jacomine JC , Giacomini M , Agulhari MA , Zabeu G , Honório H , Wang L 
Published: April 2021

Clinical Relevance
Carious and eroded dentin represent clinical challenges. The use of a universal bonding system, in a self-etching mode, associated with chlorhexidine (CHX) seems to not improve its longevity. This may be attributed to the competition for calcium between the bonding agent functional monomer and CHX.

SUMMARY

Objectives:
The purpose of this study was to explore the interaction between two calcium-dependent agents: 10-methacryloyloxydecyl-dihydrogen phosphate (MDP) and 2% chlorhexidine (CHX) digluconate in association with a self-etching universal bonding system.

Methods and Materials:
Flat dentin surfaces were obtained from 120 specimens (n=20/group) prepared from extracted sound human third molars and randomly divided into three groups according to the dentin substrate: sound ([S] control), artificial carious ([C] 6 h/demineralization + 18 h/remineralization for 5 days + 48 h/remineralization), and artificial eroded ([E] 3 cycles for 5 min/day for 5 days using orange juice). Before bonding procedures, one-half of the specimens from each group were pretreated with deionized water (W) and the other half with 2% chlorhexidine (CHX), forming six groups: S-W, S-CHX, C-W, C-CHX, E-W, and E-CHX. All specimens were restored with Adper Single Bond Universal (self-etching mode) and two increments of composite resin (Filtek Z-250), following the manufacturer’s instructions. Slices (0.8 mm) were obtained from the specimens and subjected to scanning electron microscopy (SEM) analysis and sticks (0.64 mm2) were obtained and subjected to a microtensile bond strength test (μTBS) in a universal testing machine (0.5 mm/min) after 24 hours and 6 months of storage. Failure modes were classified using optical microscopy (40×). Data was statistically analyzed by three-way ANOVA and Tukey tests (p&lt;0.05).

Results:
Substrate type was a statistically significant factor (p&lt;0.0001), whereas neither the pretreatment (p=0.189) nor time (p=0.337) were significant. No interaction considering all the factors was significant (p=0.453). Conclusions: Carious and eroded dentin substrates negatively interfered with the bonding potential of an MDP-based universal bonding system, regardless of the use of CHX. Likely, the reduction of available calcium impaired the effectiveness of the bonding system.
The Evaluation of Different Treatments of Incipient Caries Lesions: An in Situ Study of Progression Using Fluorescence-based Methods
Authors: Diniz M , Campos P , Souza M , Guaré R , Cardoso C , Lussi A , Bresciani E 
Published: April 2021

Clinical RelevanceEffective methods to control incipient caries lesions are needed. In this investigation, several methods provide encouraging results.SUMMARYThis study aimed to evaluate in situ the inhibition of incipient caries lesion progression using different treatment protocols and to evaluate the effectiveness of fluorescence-based methods (DIAGNOdent, DIAGNOdent pen, and VistaProof fluorescence camera [FC]) in monitoring this process. The research was conducted in four phases: (1) at baseline, (2) after a first cariogenic challenge, (3) after treatment modalities, and (4) after a second cariogenic challenge. Sixteen volunteers used intraoral acrylic palatal appliances, each containing six enamel blocks (n=96). The cariogenic challenge was performed using a 20% sucrose solution over a 14-day period. The appliances were removed eight times a day and, upon removal, two drops of the solution were placed onto each enamel block. The enamel blocks were randomly assigned to three treatment groups: fluoride varnish ([FV] Duraphat; n=32), resin infiltrant ([RI] Icon; n=32), and adhesive system ([AS] Scotchbond; n=32). At the end of each phase, the surface microhardness (SMH) was measured, and two trained examiners evaluated the specimens using fluorescence-based methods. In addition, integrated mineral loss (ΔΔZ; vol%.min x μm) and lesion depth (ΔLD; μm) were evaluated using transverse microradiography. A two-way analysis of variance and a Tukey post hoc test were calculated (α=5%). Significant differences in SMH were observed according to the treatment, phases, and interaction of factors (p&lt;0.001). Treatment with FV resulted in significantly higher SMH values in phases 3 and 4 compared to RI and AS, with the last two treatments resulting in similar values (p&gt;0.05). The ΔΔZ value was similar for FV and AS but significantly higher for RI (p=0.016). ΔLD was not significantly different among the groups (p=0.126). Significant differences in the measurement of fluorescence for each fluorescence-based method were observed between each phase of the study (p&lt;0.05). It can be concluded that all treatments were effective in inhibiting the in situ progression of incipient lesions, although to different degrees, with minor mineral loss changes observed for the AS and FV. Besides, all fluorescence-based methods tested, except for that using the FC device, were effective in monitoring caries lesion progression.
20 ans de publication dans la Revue suisse des sciences de l’éducation : une rétrospective
Authors: Périsset Danièle 
Published: April 2021

Au début de l’année 2019, la Revue suisse des sciences de l’éducation (RSSE) a abandonné l’édition papier pour publier uniquement en version numérique, immédiatement libre d’accès (voir l’éditorial du n° 1-2019)[i]. Et cela faisait 20 ans que la Revue suisse des sciences de l’éducation avait remplacé la revue Éducation et recherche : revue suisse des sciences de l’éducation[ii]. Cette revue scientifique avait été créée en 1979, soit cinq ans après la fondation de la Société suisse pour la recherche en éducation (SSRE) sous l’égide de laquelle la RSSE est éditée.
20 ans de débats autour des politiques éducatives.
Authors: Mathou Cécile , Périsset Danièle , Yerly Gonzague 
Published: April 2021

Cet article propose une rétrospective des contenus des numéros thématiques de la Revue suisse des sciences de l’éducation (RSSE) portant spécifiquement sur la question des politiques éducatives, sur une période de 20 ans (2000-2020). Une analyse de contenu a été effectuée sur 15 numéros thématiques, soit 95 articles publiés dans la Revue. Afin de documenter la place des politiques éducatives dans la Revue durant les deux dernières décennies, nous avons identifié la provenance des auteur·e·s et surtout retracé l’évolution des objets traités par les contributrices et contributeurs de la Revue. Cette analyse a été guidée par cinq axes identifiés à partir des débats afférents aux politiques éducatives dans la littérature (principalement francophone) : 1) mondialisation et enquêtes internationales ; 2) réformes curriculaires ; 3) réformes de gouvernance ; 4) diversification des formes de privatisation et 5) école inclusive. Cette littérature a permis de mettre en perspective (à la fois en matière d’objets et de déplacements épistémologiques) les préoccupations présentes dans les numéros édités par la RSSE au cours des 20 dernières années dans le domaine des politiques éducatives.
Reviewing the potential use of scaffold-mediated localized chemotherapy in oncology
Authors: Gupta Archana A , Kheur Supriya , Thirumal Raj A. , Badhe Ravindra V. , Bhonde Ramesh. R. 
Published: April 2021

Abstract
Post-surgical recurrence and metastasis remain to be the major concern in oncology. The absence of any therapeutic modality during the interim period between the surgical intervention and initiation of conventional radiotherapy and chemotherapy allows the residual cancer cells to proliferate, culminating in recurrence and/or metastasis. Introducing a therapeutic modality during this interim period could suppress the proliferation of the residual tumor cells. Further, as the detrimental effects of conventional chemotherapy and radiotherapy drastically reduce the patient’s quality of life, use of therapeutic modality with localized effect can reduce the risk of systemic toxicity. Thus, the present manuscript reviews the potential use of scaffold-mediated local chemotherapy in oncology. Its localized effect would prevent systemic toxicity, while the scaffold serves as an ideal vehicle for the sustained targeted delivery of therapeutic agents.
Sistem Penentuan Penerima Shodaqo Menggunakan Metode Simple Additive Weighting
Authors: Wilarto Anjar Hero , Salamah Umniy 
Published: April 2021

Pada umumnya pemberian shodaqa dapat dilakukan di Musholla, dan pada Musholla At-Taqwa proses pemberian shodaqo masih dilakukan dengan cara pendataan data diri dan penentuan penerima Shodaqo. Dalam melakukan pendataan, panitia dari shodaqo harus melakukan survey, atau calon penerima bisa mengisi data diri ke musholla. Aktivitas tersebut sangat menyita waktu dan tidak efektif, sehingga diperlukan sistem yang lebih efektif sebagai media dalam menentukan seseorang yang layak mendapatkan shodaqo serta menguji metode SAW (Simple Additive Weighting) untuk memberikan rekomendasi peserta yang layak mendapatkan shodaqo. Ada beberapa kriteria yang diberikan oleh panitia untuk penerima shodaqo seperti data tempat usaha, data rumah, data pekerjaan, data inventaris, dan data penghasilan. Selanjutnya kriteria diolah menggunakan aplikasi yang dibangun menggunakan menggunakan metode Simple Additive Weighting. Hasil dari perangkingan diatas diperoleh V1 = 0.666 dan V2 = 1. Dan dengan data hasil perangkingan diatas dapat disimpulkan bahwa V2 yang berhak dalam menerima shodaqa karena telah sesuai dengan kriteria yang ditentukan. Sistem ini terbukti dapat membantu proses penentuan penerima shodaqa berdasarkan data kriteria yang telah dipilih oleh user dan memudahkan pihak panitia. Sistem ini diharapkan dapat menjadi alat bantu untuk proses pengambilan keputusan dalam penentuan penerima shodaqo di Musholla At- Taqwa.
Initial Accuracy of Word-Referent Mappings Affects Word Learning
Authors: Choi Elaine 
Published: April 2021

It was previously assumed that a correct, or accurate, initial association between a word and its referent allows optimal language learning, since fewer cognitive resources are required. However, some studies have found that initially incorrect, or inaccurate, associations can cause adults to learn word-referent mappings significantly better, compared to initially accurate ones. The opposite effect was found in children, who typically learn better when a word-referent association is consistently accurate.Our research project further explores these findings. The study involves a cross-situational word-learning paradigm examining whether the correction of inaccurate initial word-referent associations benefits word learning. Eye fixation and pupil dilation data are used to determine initial mappings and cognitive load, respectively. In the familiarisation phase of the study, participants are presented with associations between made-up words and the images to which the words refer; initial accuracy is manipulated such that only half of the presented associations are correct. Then, in the learning phase, each word is presented with its correct referent. Finally, the accuracy of the learned word-referent mappings is tested.Our initial findings confirm that word learning benefits when adults are presented with initially inaccurate associations and subsequent corrections. We will discuss the theories behind these findings, as well as the implications for language learning. In the most recent phase of the project, we are determining whether pupil dilation is a good measure for increased cognitive load associated with word-referent inaccuracy.
Insect Herbivory on the Plant Rhinanthus minor over its Elevational Range in the Canadian Rockies
Authors: Falk Lindsey 
Published: April 2021

All species of plants and animals occur over a finite area of the Earth’s surface. This is referred to as the species range, and many species ranges have shifted or are predicted to shift with climate change. Scientific models have predicted how these shifts are expected to change and what proportion of the implicated species will go extinct in the process. Most models assume that climatic variables such as temperature and rainfall are solely responsible for these range shifts. However, we know that the success of a species is strongly influenced by both their positive and negative interactions with other species, such as competition, mutualism, predation and herbivory. But how these biotic factors affect species ranges is poorly understood. I am using a field experiment on a species in its native habitat to better understand these interactions. My study took place in the Canadian Rocky Mountains on populations of the plant Yellow Rattle (Rhinanthus minor). I studied two transects, each with plant populations at low, mid and high elevations. Insect herbivory on plant populations was observed, as well as manipulated, via a pesticide treatment to reduce insect herbivory, and a clipping treatment to simulate natural insect herbivory. Understanding herbivory and herbivore-plant interactions over an elevational gradient may help give us a clearer idea of the complex relationship between the climatic and biotic factors that affect plant species ranges.
11. Mitigation of Wildlife Collision Mortality at Little Cataraqui Creek Wetland
Authors: Keenan Erin , Henderson Jeffy , Malo Lauren , Pedersen Diana 
Published: April 2021

Our research team is concerned with potential reptile and amphibian road mortality through Little Cataraqui Creek wetland along Front Rd. and Bath Rd. in Kingston, Ontario. The coastal marsh is a provincially significant wetland that supports species of migrating and breeding waterfowl, wetland dependent reptiles and amphibians, and may support some of Ontario’s threatened turtle species. The coastal wetland also provides a protected nesting area for a migrating species within Lake Ontario. Specific species of turtles, salamanders and frogs will be investigated. Our team will identify general breeding, nesting and migratory behavior patterns of associated wetland species, and establish potential indirect effects on the wetland ecosystem due to population decline. Traffic volume and speed limits of Front Rd. and Bath Rd. at Little Cataraqui Creek Wetland will be identified, and any current wildlife crossing systems in place will be evaluated. Based on this research, our team will establish the significance of wildlife road mortality within Little Cataraqui Creek Wetland at Front Rd. and Bath Rd., and propose suitable mitigation techniques. These techniques may include implementing structural design solutions such as road barriers, culverts, etc., as well as increasing public awareness of wildlife crossing on Bath Rd. and Front Rd. by proposing appropriate traffic laws in the area. Themes include wetland species breeding and nesting behavior, and urban/traffic development issues surrounding wetland ecosystems.
Potensi Ekstrak Kunyit (Curcuma longa) Terhadap Kadar Ischemia Modified Albumin (IMA) pada Tikus Model Penyakit Jantung Koroner
Authors: Dharmaputra Gde Arisetyawan , Veronica Elvina , Driansha Cindy Liora , Satyarsa Agung Bagus Sista , Dewi Ni Wayan Sucindra 
Published: April 2021

Penyakit Jantung Koroner (PJK) adalah penyakit kardiovaskuler akibat penyempitan pembuluh darah koroner yang menyebabkan iskemia miokard, sehingga mengakibatkan apoptosis sel. Kunyit mengandung senyawa yang berperan sebagai anti inflamasi, seperti kurkumin. Tujuan: Menentukan pengaruh kandungan kurkumin pada kunyit (Curcuma longa) terhadap kadar Ischemia Modified Albumin (IMA). Metode: Desain penelitian ini adalah rancangan post-test only control group dengan menggunakan tikus wistar jantan sebanyak 30 ekor yang terbagi ke dalam 5 kelompok yaitu, kelompok 1 kontrol negatif, kelompok 2 kontrol positif, kelompok perlakuan 1, 2, dan 3. Kelompok perlakuan masing-masing mendapatkan ekstrak kunyit dengan variasi dosis 50, 100, dan 200 mg/kgBB. Pemeriksaan kadar IMA dalam serum darah menggunakan teknik ELISA. Data dianalisis dengan uji One-Way Anova. Hasil: Kadar IMA pada masing masing kelompok adalah kelompok 1 kontrol negative = 300,471 ng/mL, kelompok 2 kontrol positif = 333,357 ng/mL, kelompok perlakukan 1 dosis 50mg/kg = 232,317 ng/mL, kelompok perlakukan 2 dosis 100 mg/kgBB = 173,385 ng/mL, dan kelompok perlakuan 3 dosis 200 mg/kgBB = 217,358 ng/mL. Hasil analisis statistik menunjukkan tidak terdapat perbedaan yang bermakna kadar IMA antara semua kelompok penelitian, yakni kelompok kontrol positif, kontrol negatif, maupun kelompok perlakuan (p>0,05). Berdasarkan Independent t-test menunjukkan terdapat perbedaan yang bermakna kadar IMA antara kelompok perlakuan ekstrak kunyit 100 mg/kgBB, 200 mg/kgBB dengan kelompok kontrol positif. Simpulan: Ekstrak kunyit berpengaruh terhadap kadar IMA.Kata kunci: IMA, kunyit, kurkumin
Efek Glycine Soja Terhadap Angiogenesis dan Histologi Aorta Tikus Ovariektomi
Authors: Yuliawati Dwi , Astuti Wuri Widi 
Published: April 2021

Resiko CVD meningkat secara tajam pada menopause yang disebabkan oleh perkembangan aterosklerosis ditandai adanya penebalan intima patologis pada aorta. Tujuan: Membuktikan pemberian ekstrak kedelai hitam (Glycine soja) dapat meningkatkan ekspresi VEGF, diameter aorta dan menurunkan ketebalan media intima aorta tikus ovariektomi. Ovariektomi dilakukan untuk membuat hewan model menopause. Metode: Tikus dibagi menjadi lima kelompok: Kontrol Negatif, Positif, tiga Perlakuan (dosis 50,100,150 mg/200grBB/hari). Ovariektomi dilakukan pada kelompok kontrol positif dan perlakuan.Tiga puluh hari post ovariektomi, pada kelompok perlakuan diberikan ekstrak kedelai hitam sesuai dosis selama 30 hari. Terminasi dilakukan untuk pengambilan aorta pada seluruh kelompok. Pemeriksaan ketebalan media intima dan diameter aorta menggunakan HE, sedangkan VEGF menggunakan immunohistokimia. Hasil: Uji One Way Anova terhadap diameter aorta dan VEGF, didapatkan p = 0,000 (p<0,05 ), yang berarti terdapat pengaruh signifikan pemberian ekstrak kedelai hitam terhadap peningkatan diameter dan VEGF aorta tikus ovariektomi. Uji Post Hock Tukey menunjukkan peningkatan diameter aorta dan VEGF signifikan pada seluruh kelompok perlakuan dibandingkan kelompok kontrol positif. Uji One Way Anova terhadap ketebalan media intima didapatkan p = 0,410, yang berarti tidak terdapat pengaruh yang signifikan pemberian ekstrak kedelai hitam terhadap penurunan ketebalan media intima aorta tikus ovariektomi. Rerata ketebalan terendah terdapat pada kelompok Perlakuan 1 dibawah rerata ketebalan media intima kelompok kontrol positif. Simpulan: Pemberian ekstrak kedelai hitam meningkatkan secara signifikan ekspresi VEGF dan diameter aorta, namun tidak berpengaruh secara signifikan dalam menurunkan ketebalan media intima aorta tikus ovariektomi.Kata kunci: diameter aorta, kedelai hitam, ketebalan media intima aorta, VEGF
Profil Ekspresi MikroRNA Kanker Payudara di Purwokerto
Authors: Nurasih Ari Dwi , Sulistiyawati Indah , Falah Muhammad 
Published: April 2021

Penemuan metode deteksi dini kanker payudara secara sensitif, spesifik dan minimal invasif merupakan kunci dalam keberhasilan pengobatan. Hal ini dapat dilakukan menggunakan biomarker yang bersirkulasi dalam plasma darah yaitu mikroRNA. MikroRNA adalah asam ribonukleat yang tidak mengkode protein tetapi memiliki peran dalam menghambat dan mendegradasi mRNA sehingga mempengaruhi perkembangan kanker. Tujuan: Mengetahui profil ekspresi mikroRNA pada pasien kanker payudara di Purwokerto dan mikroRNA yang mengalami disregulasi sebagai kandidat biomarker kanker payudara. Metode: Analisis profil ekspresi mikroRNA pada kanker payudara dilakukan dengan isolasi plasma dari pasien kanker payudara dan individu sehat, sintesis cDNA, dan kuantifikasi mikroRNA dengan quantitative real time PCR (qPCR). Kemudian dilakukan penghitungan dengan metode Livak untuk mengetahui mikroRNA yang mengalami peningkatan dan penurunan ekspresi yang signifikan. Hasil: Biomarker kanker payudara di Purwokerto adalah MikroRNA yang mengalami upregulation adalah hsa-miR-543 (sebanyak 1612,28 kali), hsa-miR-495-3p (1797,95 kali), hsa-miR-382-5p (8780,32 kali), hsa-miR-155-5p (8552,18 kali) dan hsa-miR-154-5p (2339,41 kali). mikroRNA yang mengalami downregulation adalah hsa-miR-590-5p (sebanyak 4,70 kali), hsa-miR-33a-5p (sebanyak 74,29 kali), hsa-miR-100-5p (sebanyak 23,09 kali), hsa-miR-19b-3p (sebanyak 11,71 kali) dan hsa-miR-144-3p (sebanyak 25,30 kali) (p < 0,05). Simpulan: Biomarker yang dapat digunakan sebagai alat deteksi dan diagnostik dini kanker payudara di Purwokerto adalah miR-382-5p.Kata kunci: biomarker, kanker payudara, mikroRNA, qPCR