bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-transplantation cyclophosphamide reduces the incidence of acute graft-versus-host disease in patients with acute myeloid leukemia/myelodysplastic syndromes who receive immune checkpoint inhibitors after allogeneic hematopoietic stem cell transplantation
Authors: Saberian Chantal , Abdel-Wahab Noha , Abudayyeh Ala , Rafei Hind , Joseph Jacinth , Rondon Gabriela , Whited Laura , Gruschkus Stephen , Fa'ak Faisal , Daher May , Knape Cristina , Safa Houssein , Shoukier Mahran , Suarez-Almazor Maria E , Marcotulli Megan , Ludford Kaysia , Gulbis Alison M , Konopleva Marina , Ohanian Maro , Ravandi Farhad , Garcia-Manero Guillermo , Oran Betul , Popat Uday R , Mehta Rotesh , Alousi Amin M , Daver Naval , Champlin Richard , Diab Adi , Al-Atrash Gheath 
Published: February 2021

BackgroundImmune checkpoint inhibitors (ICIs) are being used after allogeneic hematopoietic stem cell transplantation (alloHCT) to reverse immune dysfunction. However, a major concern for the use of ICIs after alloHCT is the increased risk of graft-versus-host disease (GVHD). We analyzed the association between GVHD prophylaxis and frequency of GVHD in patients who had received ICI therapy after alloHCT.MethodsA retrospective study was performed in 21 patients with acute myeloid leukemia (n=16) or myelodysplastic syndromes (n=5) who were treated with antiprogrammed cell death protein 1 (16 patients) or anticytotoxic T lymphocyte-associated antigen 4 (5 patients) therapy for disease relapse after alloHCT. Associations between the type of GVHD prophylaxis and incidence of GVHD were analyzed.ResultsFour patients (19%) developed acute GVHD. The incidence of acute GVHD was associated only with the type of post-transplantation GVHD prophylaxis; none of the other variables included (stem cell source, donor type, age at alloHCT, conditioning regimen and prior history of GVHD) were associated with the frequency of acute GVHD. Twelve patients received post-transplantation cyclophosphamide (PTCy) for GVHD prophylaxis. Patients who received PTCy had a significantly shorter median time to initiation of ICI therapy after alloHCT compared with patients who did not receive PTCy (median 5.1 months compared with 26.6 months). Despite early ICI therapy initiation, patients who received PTCy had a lower observed cumulative incidence of grades 2–4 acute GVHD compared with patients who did not receive PTCy (16% compared with 22%; p=0.7). After controlling for comorbidities and time from alloHCT to ICI therapy initiation, the analysis showed that PTCy was associated with a 90% reduced risk of acute GVHD (HR 0.1, 95% CI 0.02 to 0.6, p=0.01).ConclusionsICI therapy for relapsed acute myeloid leukemia/myelodysplastic syndromes after alloHCT may be a safe and feasible option. PTCy appears to decrease the incidence of acute GVHD in this cohort of patients.
Association of fine particulate matter with glucose and lipid metabolism: a longitudinal study in young adults
Authors: Qin Jingyi , Xia Wei , Liang Gaodao , Xu Shunqing , Zhao Xiuge , Wang Danlu , Sun Xiaojie , Li Yuanyuan , Liu Hongxiu 
Published: February 2021

ObjectivesThis study aimed to evaluate whether PM2.5exposure in a highly polluted area (>100 µg/m3) affects glucose and lipid metabolism in healthy adults.MethodsWe recruited 110 healthy adults in Baoding city, Hebei, China, and followed them up between 2017 and 2018. Personal air samplers were used to monitor personal PM2.5levels. Eight glucose and lipid metabolism parameters were quantified. We performed the linear mixed-effect models to investigate the relationships between PM2.5and glucose and lipid metabolism parameters. Stratified analyses were further performed according to sex and body mass index (BMI).ResultsThe concentration of PM2.5was the highest in spring, with a median of 232 μg/m3and the lowest in autumn (139 μg/m3). After adjusting for potential confounders, we found that for each twofold increase in PM2.5, the median of insulin concentration decreased by 5.89% (95% CI −10.91% to −0.58%; p<0.05), and ox-LDL increased by 6.43% (95% CI 2.21% to 10.82%; p<0.05). Stratified analyses indicated that the associations were more pronounced in females, overweight and obese participants.ConclusionsExposure to high PM2.5may have deleterious effects on glucose and lipid metabolism. Females, overweight and obese participants are more vulnerable.
Scoping review of COVID-19-related systematic reviews and meta-analyses: can we really have confidence in their results?
Authors: Wurth Rachel , Hajdenberg Michelle , Barrera Francisco J , Shekhar Skand , Copacino Caroline E , Moreno-Peña Pablo J , Gharib Omar A M , Porter Forbes , Hiremath Swapnil , Hall Janet E , Schiffrin Ernesto L , Eisenhofer Graeme , Bornstein Stefan R , Brito Juan P , González-González José Gerardo , Stratakis Constantine A , Rodríguez-Gutiérrez René , Hannah-Shmouni Fady 
Published: February 2021

AbstractAimThe aim of this study was to systematically appraise the quality of a sample of COVID-19-related systematic reviews (SRs) and discuss internal validity threats affecting the COVID-19 body of evidence.DesignWe conducted a scoping review of the literature. SRs with or without meta-analysis (MA) that evaluated clinical data, outcomes or treatments for patients with COVID-19 were included.Main outcome measuresWe extracted quality characteristics guided by A Measurement Tool to Assess Systematic Reviews-2 to calculate a qualitative score. Complementary evaluation of the most prominent published limitations affecting the COVID-19 body of evidence was performed.ResultsA total of 63 SRs were included. The majority were judged as a critically low methodological quality. Most of the studies were not guided by a pre-established protocol (39, 62%). More than half (39, 62%) failed to address risk of bias when interpreting their results. A comprehensive literature search strategy was reported in most SRs (54, 86%). Appropriate use of statistical methods was evident in nearly all SRs with MAs (39, 95%). Only 16 (33%) studies recognised heterogeneity in the definition of severe COVID-19 as a limitation of the study, and 15 (24%) recognised repeated patient populations as a limitation.ConclusionThe methodological and reporting quality of current COVID-19 SR is far from optimal. In addition, most of the current SRs fail to address relevant threats to their internal validity, including repeated patients and heterogeneity in the definition of severe COVID-19. Adherence to proper study design and peer-review practices must remain to mitigate current limitations.
Associations between haemodynamics and wall enhancement of intracranial aneurysm
Authors: Zhang Miaoqi , Peng Fei , Tong Xin , Feng Xin , Li Yunduo , Chen Huijun , Niu Hao , Zhang Baorui , Song Guangrong , Li Youxiang , Liu Peng , Liu Aihua , Li Rui 
Published: February 2021

Background and purposePrevious studies have reported about inflammation processes (IPs) that play important roles in aneurysm formation and rupture, which could be driven by blood flow. IPs can be identified using aneurysmal wall enhancement (AWE) on high-resolution black-blood MRI (BB-MRI) and blood flow haemodynamics can be demonstrated by four-dimensional-flow MRI (4D-flow MRI). Thus, this study investigated the associations between AWE and haemodynamics in unruptured intracranial aneurysms (IA) by combining 4D-flow MRI and high-resolution BB-MRI.Materials and methodsBetween April 2014 and October 2017, 48 patients with 49 unruptured IA who underwent both 4D-flow MRI and high-resolution BB-MRI were retrospectively included in this study. The haemodynamic parameters demonstrated using 4D-flow MRI were compared between different AWE patterns using the Kruskal-Wallis test and ordinal regression.ResultsThe results of Kruskal-Wallis test showed that the average wall shear stress in the IA (WSSavg-IA), maximum through-plane velocity in the adjacent parent artery, inflow jet patterns and the average vorticity in IA (vorticityavg-IA) were significantly associated with the AWE patterns. Ordinal regression analysis identified WSSavg-IA(p=0.002) and vorticityavg-IA(p=0.033) as independent predictors of AWE patterns.ConclusionA low WSS and low average vorticity were independently associated with a high AWE grade for IAs larger than 4 mm. Therefore, WSS and average vorticity could predict AWE and circumferential AWE.
Cessation rates from a national collective social network smoking cessation programme: results from the ‘I quit smoking with Facebook on March 21’ Swiss programme
Authors: Desrichard Olivier , Moussaoui Lisa S , Blondé Jérôme , Felder Max , Riedo Gisana , Folly Laura , Falomir-Pichastor Juan M 
Published: February 2021

BackgroundProgrammes for collective smoking cessation, based on the British model Stoptober, are proposed by public health units in many countries. There is a need for data estimating the rate at which participants in these programmes are successful in quitting smoking. We report a prospective study carried out as part of a large-scale collective cessation programme conducted in Switzerland in 2017.Methods1112 participants among the 7008 smokers enrolled in the collective cessation programme were recruited before the start of the attempt. Continuous abstinence was measured 10 days, 3 months and 6 months after the start of the attempt. Participants who dropped out at follow-up were considered to have failed the attempt (worst-case scenario).ResultsThe continuous abstinence rate was at least 37.9% at 10-day follow-up, 18.8% at 3-month follow-up and 13.1% at 6-month follow-up. Similar levels of continuous abstinence as the worst-case scenario were found in sensitivity analyses including those whose quit attempt started before the beginning of the programme and where multiple imputation was used to replace dropouts. Sensitivity analyses using complete cases or an indicator of abstinence which allows occasional lapses found around double the abstinence rates.ConclusionsOur results support the potential usefulness of large-scale collective cessation campaigns and suggest that such programmes based on social networks are promising areas for future smoking cessation programme activity.
Fermion spectrum and $$g-2$$ anomalies in a low scale 3-3-1 model
Authors: Hernández A. E. Cárcamo , Velásquez Yocelyne Hidalgo , Kovalenko Sergey , Long H. N. , Pérez-Julve Nicolás A. , Vien V. V. 
Published: February 2021

AbstractWe propose a renormalizable theory based on the $$SU(3)_C\times SU(3)_L\times U(1)_X$$

S
U

(
3
)

C

×
S
U

(
3
)

L

×
U

(
1
)

X

gauge symmetry, supplemented by the spontaneously broken $$U(1)_{L_g}$$

U

(
1
)

L
g

global lepton number symmetry and the $$S_3 \times Z_2 $$

S
3

×

Z
2

discrete group, which successfully describes the observed SM fermion mass and mixing hierarchy. In our model the top and exotic quarks get tree level masses, whereas the bottom, charm and strange quarks as well as the tau and muon leptons obtain their masses from a tree level Universal seesaw mechanism thanks to their mixing with charged exotic vector like fermions. The masses for the first generation SM charged fermions are generated from a radiative seesaw mechanism at one loop level. The light active neutrino masses are produced from a loop level radiative seesaw mechanism. Our model successfully accommodates the experimental values for electron and muon anomalous magnetic dipole moments.
Wiener index via wirelength of an embedding
Authors: Nandini G. Kirithiga , Rajan R. Sundara , Rajalaxmi T. M. , Shantrinal A. Arul , Husain Sharifah Kartini Said , Hasni Roslan 
Published: February 2021

Embeddings are often viewed as a high-level representation of systematic methods to simulate an algorithm designed for one kind of parallel machine on a different network structure and/or techniques to distribute data/program variables to achieve optimum use of all available processors. A topological index is a numeric quantity of a molecule that is mathematically derived in an unambiguous way from the structural graph of a molecule. In theoretical chemistry, distance-based molecular structure descriptors are used for modeling physical, pharmacologic, biological and other properties of chemical compounds. Arguably, the best known of these indices is the Wiener index, defined as the sum of all distances between distinct vertices. In this paper, we have obtained the exact wirelength of embedding Cartesian products of complete graphs into a Cartesian product of paths and cycles, and generalized book. In addition to that, we have found the Wiener index of generalized book and the relation between the Wiener index and wirelength of an embedding, which solves (partially) an open problem proposed in Kumar et al. [K. J. Kumar, S. Klavžar, R. S. Rajan, I. Rajasingh and T. M. Rajalaxmi, An asymptotic relation between the wirelength of an embedding and the Wiener index, submitted to the journal].
Effects of melt-percolation, refertilization and deformation on upper mantle seismic anisotropy: constraints from peridotite xenoliths, Marie Byrd Land, West Antarctica
Authors: Chatzaras Vasileios , Kruckenberg Seth C. 
Published: February 2021

Abstract
We report on the petrology, microstructure and seismic properties of 44 peridotite xenoliths extracted from the upper mantle beneath Marie Byrd Land (MBL), West Antarctica. The aim of this work is to understand how melt-rock reaction, refertilization, and deformation affected the seismic properties (velocities, anisotropy) of the West Antarctic upper mantle, in the context of MBL tectonic evolution and West Antarctic Rift System formation. Modal compositions, mineral major element compositions, microstructures, and crystallographic preferred orientations (CPOs) provide evidence for diachronous reactive melt percolation and refertilization. Olivine shows three main CPO patterns, the A-type, axial-[010], and axial-[100] texture types. Average seismic properties of the MBL mantle lithosphere are mainly controlled by the strength of olivine crystallographic texture. Reactive melt percolation and refertilization likely modified seismic velocities and anisotropy, as is suggested by a systematic decrease in maximum P-wave and S-wave anisotropies with increasing modal abundance of pyroxene. At larger spatial scales, the seismic properties of the MBL mantle xenoliths are dominated by the anisotropy resulting from the A-type olivine CPO. Variations between individual volcanic centres, however, attest to spatial variations in the mantle structure, potentially related to 3D deformation and the prolonged tectonic history of MBL.
Combining process-based models and multiple-point geostatistics for improved reservoir modelling
Authors: Mullins James , van Der Vegt Helena , Howell John 
Published: February 2021

The construction of subsurface reservoir models is typically aided by the use of outcrops and modern analogue systems. We show how process-based models of depositional systems help to develop and substantiate reservoir architectural concepts. Process-based models can simulate assumptions relating to the physical processes influencing sedimentary deposition, accumulation and erosion on the resultant 3D sediment distribution. In this manner, a complete suite of analogue geometries can be produced by implementing different sets of boundary conditions based on hypotheses of depositional controls. Simulations are therefore not driven by a desired/defined outcome in the depositional patterns, but their application to date in reservoir modelling workflows has been limited because they cannot be conditioned to data such as well logs or seismic information.
In this study a reservoir modelling methodology is presented that addresses this problem using a two-step approach: process-based models producing 3D sediment distributions that are subsequently used to generate training images for multi-point geostatistics.
The approach has been tested on a dataset derived from a well-exposed outcrop from central Utah. The Ferron Sandstone Member includes a shallow-marine deltaic interval that has been digitally mapped using a high-resolution unmanned aerial vehicle (UAV) survey in 3D to produce a virtual outcrop (VO). The VO was used as the basis to build a semi-deterministic outcrop reference model (ORM) against which to compare the results of the combined process/multiple-point statistics (MPS) geostatistical realizations. Models were compared statically and dynamically through flow simulation.
When used with a dense well dataset, the MPS realizations struggle to account for the high levels of non-stationarity inherent in the depositional system that are captured in the process-based training image. When trends are extracted from the outcrop analogue and used to condition the simulation, the geologically realistic geometries and spatial relationships from the process-based models are directly imparted onto the modelling domain, whilst simultaneously allowing the facies models to be conditioned to subsurface data.
When sense-checked against preserved analogues, this approach reproduces more realistic architectures than traditional, more stochastic techniques.
The Acceptability, Feasibility, and Effectiveness of Breast Massage Combined with Acupoint Stimulation to Promote the Volume of Human Milk in Mothers with Preterm Infants: A Pilot Study
Authors: Sheng Jia , Ding Yan , Wang Jing , Zhang Junping , Qi Xingling , Xia Haiou 
Published: February 2021

Background. Preterm infant mothers have always encountered difficulties in human milk production. For this reason, an intervention of breast massage combined with acupoint stimulation was designed to increase the production. Purpose. Through a pilot randomized trial, we assessed the acceptability, feasibility, and effectiveness of breast massage combined with acupoint stimulation and the study procedures. Methods. 40 participants of preterm infants born at less than 34 weeks of gestation were randomly allocated to the CG (control group) or the EG (group with breast massage combined with acupoint stimulation). Data related to the acceptability, feasibility, and effectiveness of the intervention and research procedures were collected and analysed. Results. The daily volume progressively increased each day in the first 7 days in both groups and a significant difference was observed between the groups (

P

< 0.001). The initiation time of lactogenesis stage II was 50.06 ± 6.78 (40.00–64.00) hours in the EG and 66.18 ± 14.64 (48.00–96.00) hours in the CG, where a significant difference was detected (

P

< 0.05). The mean score of satisfaction with the intervention in the EG was 4.56 ± 0.32 (4.0–5.0), while the retention rates were 82.5% and 85.5% (17/20) in the CG, and 80% (16/20) in the EG. Conclusion. This pilot study was oriented towards the effectiveness of breast massage combined with acupuncture stimulation for the increase of human milk production in the participants. The intervention was accepted well and the study process was reasonable. A large-scale RCT will be able to determine the beneficial effects of this intervention on human milk production.
Malacofaunal inventory in Chintamoni Kar Bird Sanctuary, West Bengal, India
Authors: Sajan S.K. , Das Swati , Tripathy Basudev , Biswas Tulika 
Published: February 2021

The knowledge on the floral and faunal composition of protected areas (PAs) is crucial for formulating suitable conservation plan. In this paper, inventory and species richness of non-marine molluscs of Chintamoni Kar Bird Sanctuary has been made and is for the first time from any PA of West Bengal. A total of 276 specimens belonging to 22 species (10 species of land snails and 12 species of freshwater) of non-marine molluscs (land and freshwater) were collected and examined from this sanctuary. The malacofaunal inventory comprises of nine genera under seven families among land snails and 12 genera & seven families from both gastropods & bivalves under the freshwater forms. As far as species richness is concerned, the family Ariophantidae was found to be dominant among land forms whereas species of the families Thiaridae and Unionidae were dominant among freshwater forms.
High altitude wetland migratory birds in the Sikkim Himalaya: a future conservation perspective
Authors: Chhetri Prem K. , Gurung Kusal , Lepcha Thinlay Namgyal , Chhetri Bijoy 
Published: February 2021

Ferruginous Duck Aythya nyroca (Güldenstädt, 1770) and Brown-headed Gull Chroicocephalus brunnicephalus (Jerdon, 1840), two high altitude wetland migratory birds, were recorded for the first time from Sikkim, eastern Himalaya. The importance of conservation of high altitude wetlands of the Sikkim Himalaya is highlighted.
Addition of four species to the flora of Andaman Islands, India
Authors: Naik Mudavath Chennakesavulu , Singh Lal Ji , Ekka Gautam Anuj , Vivek C.P. 
Published: February 2021

Chlorophytum vestitum Baker, Elatostema cuneatum Wight, Ammannia auriculata Willd., and Christisonia siamensis Craib are being reported as new distribution records for Andaman Islands. Detailed description, distribution and photographs of live individual are provided.
First record of the early immature stages of the White Four-ring Ypthima ceylonica (Insecta: Lepidoptera: Nymphalidae), and a note on a new host plant from India
Authors: Theivaprakasham Hari , Ramanasaran Hari , Pavendhan Appavu 
Published: February 2021

Documentation of the early immature stages (egg, larva, chrysalis) of the White Four-ring (Ypthima ceylonica Hewitson, 1865), including larval morphology and behaviour, is described for the first time from India. A new host plant (Cynodon dactylon (L.) Pers.) is also reported for this butterfly.
Understanding the Impacts of Upper-Tropospheric Cold Low on Typhoon Jongdari (2018) Using Piecewise Potential Vorticity Inversion
Authors: Yan Ziyu , Ge Xuyang , Wang Zhuo , Wu Chun-Chieh , Peng Melinda 
Published: February 2021

AbstractTyphoon Jongdari (2018) had an unusual looping path before making landfall in Japan, which posed a forecasting challenge for operational numerical models. The impacts of an upper-tropospheric cold low (UTCL) on the track and intensity of Jongdari are investigated using numerical simulations. The storm track and intensity are well simulated in the control experiment using the GFS analysis as the initial and boundary conditions. In the sensitivity experiment (RCL), the UTCL is removed from the initial-condition fields using the piecewise potential vorticity inversion (PPVI), and both the track and intensity of Jongdari change substantially. The diagnosis of potential vorticity tendency suggests that horizontal advection is the primary contributor for storm motion. Flow decomposition using the PPVI further demonstrates that the steering flow is strongly affected by the UTCL, and the looping path of Jongdari results from the Fujiwhara interaction between the typhoon and UTCL. Jongdari first intensifies and then weakens in the control experiment, consistent with the observation. In contrast, it undergoes a gradual intensification in the RCL experiment. The UTCL contributes to the intensification of Jongdari at the early stage by enhancing the eddy flux convergence of angular momentum and reducing inertial stability, and it contributes to the storm weakening via enhanced vertical wind shear at the later stage when moving closer to Jongdari. Different sea surface temperatures and other environmental conditions along the different storm tracks also contribute to the intensity differences between the control and the RCL experiments, indicating the indirect impacts of the UTCL on the typhoon intensity.