bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling, analysis and mitigation of self-excited vibrations of a magnetic track brake
Authors: Tippelt Daniel , Edelmann Johannes , Plöchl Manfred , Jirout Michael 
Published: October 2021

Magnetic track brakes work independently of the wheel–rail contact as an additional braking system in railway vehicles. In the past, magnetic track brakes were usually deactivated at velocities below 25 km/h in mainline applications to avoid stopping jerks. However, current demands on braking performance require activation until full stop. During field tests on this subject, severe self-excited vibrations were measured at velocities below 25 km/h. This study analyses the oscillations observed by focusing on the stability behaviour of a simplified linear coupled electro-magneto-mechanical model of the track brake. Key parameters are identified by applying established criteria of linear stability theory. To account for essential nonlinear effects, a detailed multibody dynamics model with flexible bodies including a more enhanced electro-magnetic model is introduced and parameterised by using measurement data. Simulation results reveal two separate (or combined) mechanisms that may lead to self-excitation. On the one hand, friction-induced vibrations between the magnets and the rail; on the other hand, coupling effects between the electro-magnetic and the mechanical subsystems of the track brake may be the cause of the self-excited vibrations observed. Stability behaviour is influenced by various design parameters and in particular by the contact conditions between track brake and rail. Finally, a few passive methods are briefly discussed that may help to mitigate or reduce self-excited vibrations at low velocities in future designs of track brakes.
Systematic Review: Investigating the Impact of COVID-19 on Mental Health Outcomes of Individuals With ADHD
Authors: Behrmann Julie T. , Blaabjerg Julie , Jordansen Josefine , Jensen de López Kristine M. 
Published: October 2021

Background: According to the WHO, the COVID-19 pandemic could have a negative impact on the mental health of individuals, such as an exacerbation of existing difficulties. Individuals with ADHD may be specifically challenged by the pandemic. Aims: To provide a systematic review of evidence regarding the COVID-19’s impact on mental health of individuals with ADHD during the COVID-19 lockdown. Methods: This registered review (PROSPERO ID CRD42021238770) adhered to Prisma guidelines. Systematic searches in electronic databases PubMed and PsycINFO were carried out. A total of 12 studies covering 3,028 subjects were included. Results: COVID-19 pandemic is associated with increased ADHD symptoms and psychological difficulties. Some studies reported that individuals experienced positive outcomes. The methodological quality of the studies was low to moderate. Conclusion: COVID-19 can affect the mental health of individuals with ADHD negatively, although methodological limitations should be considered. Further research should generate knowledge about long-term effects impact of the pandemic and about appropriate support.
Evaluation of optical coherence tomography findings in adolescents with genetic generalized epilepsy
Authors: Kaplan Aysin Tuba , Oskan Yalcın Sibel , Sager Safiye Gunes 
Published: October 2021

Objective To evaluate retinal nerve fiber layer (RNFL) thickness, central macular thickness (CMT), and subfoveal choroid thickness (CT) by using optical coherence tomography (OCT) in adolescents with newly diagnosed epilepsy and patients who had been using Na valproate (VPA) for at least 1 year. Methods We examined 60 patients with genetic generalized epilepsy (GGE) aged 8–17 years. Thirty patients with newly diagnosed GGE who were evaluated before the beginning of the therapy and another 30 patients who were chosen from among adolescents with epilepsy using VPA for at least 1 year were included in the study. Results Nasal quadrant RNFL thickness and CMT measurements were significantly lower in the monotherapy group compared with the newly diagnosed group ( p = 0.044 and p = 0.032, respectively). CT measurements were not significantly different between the groups ( p = 0.413). There was a negative correlation in regression analysis between the duration of drug use and RNFL thickness in all quadrants. Conclusion According to our study, we observed thinning of the nasal RNFL and macular thickness in adolescents with epilepsy who were using Na valproate for at least 1 year and that as the duration of use increased, the thinning occurred in all RNFL quadrants. Further studies with larger series are needed to better understand the effects of both epilepsy and VPA on the eye.
Side press-and-release technique in endothelium-in descemet membrane endothelial keratoplasty(DMEK): A novel technique
Authors: Siu Gillian DJY , Wu Macy MS , Wong Amy L 
Published: October 2021

Purpose To describe a novel technique in unfolding an endothelium-in Descemet membrane (DM) graft. Methods New surgical technique description Results We describe a novel technique that allows immediate and controlled unfolding of the endothelium-in Descemet membrane graft that was successful in 5 of our DMEK patients. It is essential to acquire this “side press-and-release” technique when the graft does not unfold spontaneously as expected. Conclusions This controlled and simple manoeuvre is an efficient and safe method of unfolding an endothelium-in DM graft.
Hybrid Closed-Loop Control with Ultrarapid Lispro Compared with Standard Insulin Aspart and Faster Insulin Aspart: An In Silico Study
Authors: Lachal Sylvain , Tourki Yousra , Franc Sylvia , Huneker Erik , Charpentier Guillaume , Benhamou Pierre Yves 
Published: October 2021

Objective: There is room for improvement in the performance of closed-loop regulation algorithms during the prandial period. This in silico study evaluated the efficiency and safety of ultrarapid lispro insulin using the Diabeloop DBLG1® algorithm. Methods: We modeled the insulin profile of URLi according to literature data and integrated it to the model used within a simulation platform built from a 60 patients’ virtual cohort. We then ran the DBLG1® algorithm in silico with various meal intakes using modeled URLi, Aspart and Faster Aspart. The primary endpoints were glucose metrics (time in 70-180 mg/dL range and time below range). Results: When insulin time constant values were tuned, time in 70-180 mg/dL range was 69.4 [61.1-75.6] (Aspart) vs 74.7 [65.5-81.5] (URLi). Glucose coefficient of variation was reduced from 34.1 [29.7-37.8] to 28.4 [25.7-34.6]. Time below 70 mg/dL and 54 mg/dL were significantly reduced with URLi, whether or not DBLG1 was specifically tuned to this insulin. Metrics with Faster Aspart were intermediate and did not significantly differ from URLi. Conclusions: This simulation study performed on a virtual T1D population suggests that the use of URLi within an unmodified closed-loop DBLG1 regulation algorithm is safe and, with DBLG1 being tuned to this specific insulin type, improved the regulation performances as compared with Aspart. This fact supports the use of such an insulin in clinical investigations.
Outcomes in treatment-resistant schizophrenia: symptoms, function and clozapine plasma concentrations
Authors: Krivoy Amir , Whiskey Eromona , Webb-Wilson Henrietta , Joyce Dan , Tracy Derek K. , Gaughran Fiona , MacCabe James H. , Shergill Sukhwinder S. 
Published: October 2021

Background: Clozapine is the only medication licenced for treating patients with treatment-refractory schizophrenia. However, there are no evidence-based guidelines as to the optimal plasma level of clozapine to aim for, and their association with clinical and functional outcome. Objective: We assessed the relationship between clinical and functional outcome measures and blood concentrations of clozapine among patients with treatment-refractory psychosis. Methods: Data were reviewed in 82 patients with treatment-refractory psychosis admitted to a specialised tertiary-level service and treated with clozapine. Analysis focussed on the relationship between clozapine and norclozapine plasma concentrations and the patient’s clinical symptoms and functional status. Results: Clinical symptom improvement was positively correlated with norclozapine plasma concentrations and inversely correlated with clozapine to norclozapine plasma concentrations ratio. Clozapine concentrations showed a bimodal association with clinical improvement (peaks around 350 and 660 ng/ml). Clinical symptom improvement correlated with functional outcomes, although there was no significant correlation between the latter and clozapine or norclozapine plasma concentrations. Conclusion: Clozapine treatment was associated with optimal clinical improvement at two different peak plasma concentrations around 350 and 650 ng/ml. Clinical improvement was associated with functional outcome; however, functionality was not directly associated with clozapine concentrations. A subset of patients may require higher clozapine plasma concentrations to achieve clinical improvement.
Adherence status to iron with folic acid supplementation and associated factors among pregnant women receiving antenatal care at public health facilities in Northwest Ethiopia
Authors: Demisse Birhanu , Temesgen Habtamu , Dessie Bekalu , Kassa Getachew Mullu 
Published: October 2021

Introduction: Iron and folic acid deficiency is among the most frequent nutrient inadequacies in the world, affecting expected two billion people, and causing nearly a million deaths. The adherence rate to iron with folic acid supplements remains very low in Ethiopia. Therefore, this study aimed to assess adherence status to iron with folic acid supplementation and associated factors among pregnant women receiving antenatal care at public health facilities in Northwest Ethiopia. Methods: A facility-based cross-sectional study was conducted among pregnant women at public health facilities in the Debay Tilat Gen district from 27 February 2018 to 27 March 2018. Systematic random sampling was used to select pregnant women. Data were entered into Epidata version 3.1 and analysis was performed using SPSS version 20. Binary logistic regression was used to predict the association of the dependent variable with independent variables. Variables that showed association at a p-value of less than 0.25 in the bivariable analysis were a candidate for multivariable analysis. Finally, variables at a p-value less than 0.05 with corresponding 95% confidence interval declared statistically significant factors of iron with folic acid supplementations. Results: A total of 400 participants were included in the study. The mean (± standard deviation) age of study participants was 26.64 (±4.37 standard deviation) years. This study revealed that about 52.8% of pregnant women attending antenatal care clinics were adherent to iron with folic acid supplementation. Counseling on iron with folic acid supplementations (adjusted odd ratio = 2.53, 95% confidence interval = 1.37–4.66; p-value < 0.003), having current anemia (adjusted odd ratio = 4.21, 95% confidence interval = 1.77–9.94; p-value < 0.001), and good knowledge of iron with folic acid supplementations (adjusted odd ratio = 2.1, 95% confidence interval = 1.29–3.44; p-value < 0.003) showed statistically significant associations with adherence to iron with folic acid supplementation. Conclusion: This study revealed that more than half of pregnant women were adherent to iron with folic acid supplementation. Knowledge of iron with folic acid supplementations, current anemia, and being counseled were factors associated with pregnant women’s adherence to iron with folic acid supplementation. Therefore, counseling and awareness creation should be strengthened by health institutions.
Magnetic resonance imaging of diffusion characteristics following collagenase clostridium histolyticum injection in Dupuytren’s contracture
Authors: Iwakawa Hiroko , Uchiyama Shigeharu , Fujinaga Yasunari , Hayashi Masanori , Komatsu Masatoshi , Kato Hiroyuki , Takahashi Jun 
Published: October 2021

Purpose We aimed to evaluate the extent of collagenase clostridium histolyticum (CCH) diffusion in Dupuytren’s contracture (DC) for tissues outside of the contracture cord using Magnetic Resonance Imaging (MRI) immediately after CCH injection. Methods: 10 male patients aged 57–79 with DC of the metacarpophalangeal (MCP) joints were examined. Extension deficits were 10–60°(mean, 34.3) and 0–60°(mean, 26.6) in the MCP and proximal interphalangeal (PIP) joints, respectively. CCH injection was performed according to the standard method. MRI was performed within 15 min of CCH injection. Results: In all 10 cases, the extended area of high-intensity signal change outside of the cord was observed on short-T1 inversion recovery images (STIRs). Continuity from the insertion site was observed in the area of signal change involving the flexor tendon and neurovascular bundle. The signal change area spanned distally and proximally beyond the injection level. The signal change area expanded along the tendon sheath but no signal changes were observed inside the flexor tendon, suggesting the tendon sheath serves as a protective barrier from the CCH solution. After 1 week of injection, the mean decrease in contracture was 32.5°(94.7%) for the MCP joint and 19.8°(74.4%) for the PIP joint. In nine out of 10 cases, the extension deficit was within five degrees of full extension in the affected finger. There was no neurovascular injury or tendon rupture at 3 months of observation. Conclusions: MRI indicated the possible leakage of the drug outside of the cord during the early phase after administration, suggesting that CCH could persistently affect healthy tissues until CCH inactivates its enzyme process.
Intra-medullary antibiotics perfusion (iMAP) for the control of fracture-related infection early after osteosynthesis
Authors: Maruo Akihiro , Oda Takahiro , Miya Hidetoshi , Muratsu Hirotsugu , Fukui Tomoaki , Oe Keisuke , Kuroda Ryosuke , Niikura Takahiro 
Published: October 2021

Purpose In our hospital, cases of bone and soft tissue infections have been treated with continuous local antibiotics perfusion that allows for continuous circulation of antibiotics throughout the infected lesion. We termed this treatment “intramedullary antibiotics perfusion (iMAP)” for bone infection such as fracture-related infection (FRI) and “intrasoft tissue antibiotics perfusion” for soft tissue infection. Many cases are treated with both modalities. To introduce iMAP, this study focused on the patients with FRI treated with iMAP and reviewed their treatment outcomes. Methods We included 10 patients with FRI treated with iMAP between 2004 and 2017. The iMAP needles were inserted near the infected lesion, and an aminoglycoside antimicrobial was continuously administered. Patient characteristics, pathogenic bacteria, administered antibiotics, duration of administration, concentrations of antibiotics in blood and leachate fluid, fracture union rate, implant retention rate, and complications were studied. Results The mean age of patients was 59.9 years, and the mean follow-up period was 2.5 years. Affected bones were the tibia ( n = 8), humerus ( n = 1), and fibula ( n = 1). Deep infections developed on average 29.9 days after osteosynthesis. Pathogenic bacteria were methicillin-susceptible Staphylococcus aureus ( n = 6), methicillin-resistant S. aureus ( n = 2), and unknown ( n = 2). Average iMAP duration was 17.1 days. In all patients, infection was eradicated while preserving the implants, and fracture union was achieved without complications. Conclusion iMAP is a novel local drug delivery system allowing high concentrations of antibiotics to be administered without complications and is useful in the treatment of FRI.
Paving the Way for a Gender Diverse Future: Small and Mid-size Corporates
Authors: B. Ketan Kapoor , Tyagi Garima 
Published: October 2021

Understanding and accepting gender bias especially at the workplace is crucial to ensure more participation not only of women but also men in diversified roles irrespective of their genders. This will bridge the gap between talent and opportunities, increase productivity, widen the talent pool and encourage personal and professional growth. Gender equality is not a women issue but a human issue that affects everyone. The women were more susceptible to the pandemic-induced challenges due to already existing gender and economical inequalities. Most of them were negatively hit and their financial, social and financial status became vulnerable due to loss of livelihood, family condition and mental and physical health challenges. The Maternity Act is undoubtedly a great step towards empowering women but more needs to be done to make the ecosystem more conducive for their overall well-being. Flexible workplace policies, more benefits and special provisions will be instrumental to ease the burden on them. The need is not only to draft favourable work policies but also to make key stakeholders aware of the unconscious biases and prejudices that exist. The target of equitable development can only be achieved through a sensible, collaborative, and responsible approach.
Whiteite-(MnMnMn), a new jahnsite-group mineral species from the Foote mine, North Carolina, USA, and chemical pressure effects in jahnsite-group minerals.
Authors: Grey Ian E. , Smith Jason B. , Kampf Anthony R. , Mumme W. Gus , MacRae Colin M. , Riboldi-Tunnicliffe Alan , Boer Stephanie , Glenn Alexander M. , Gable Robert W. 
Published: October 2021

AbstractWhiteite-(MnMnMn), Mn2+Mn2+Mn2+2Al2(PO4)4(OH)2⋅8H2O, is a new whiteite-subgroup member of the jahnsite group from the Foote Lithium Company mine, Kings Mountain district, Cleveland County, North Carolina, USA. It was found in small vugs of partially oxidised pegmatite minerals on the East dump of the mine, in association with eosphorite, hureaulite, fairfieldite, mangangordonite, whiteite-(CaMnMn) and jasonsmithite. It occurs as sugary aggregates of blade-like crystals up to 0.1 mm long and as epitaxial overgrowths on whiteite-(CaMnMn). The crystals are colourless to very pale brown, with a vitreous lustre and a white streak. The blades are flattened on {001} and elongated along [010], with poor cleavage on {001}. The calculated density is 2.82 g⋅cm–3. Optically it is biaxial (–) with α = 1.599(2), β = 1.605(2), γ = 1.609(2) (white light); 2V (calc.) = 78.2°, having no observable dispersion or pleochroism, and with orientation X = b. Electron microprobe analyses and structure refinement gave the empirical formula (Mn2+0.59Ca0.38Na0.03)Σ1.00Mn1.00(Mn2+1.04Fe3+0.58Fe2+0.23Zn0.16Mg0.08)Σ2.09Al2.04(PO4)3.89(OH)3.18(H2O)7.26. Whiteite-(MnMnMn) is monoclinic, P2/a, a = 15.024(3) Å, b = 6.9470(14) Å, c = 9.999(2) Å, β = 110.71(3)°, V = 976.2(4) Å3 and Z = 2. The crystal structure was refined using synchrotron single-crystal data to wRobs = 0.057 for 2014 reflections with I > 3σ(I). Site occupancy refinements confirm the ordering of dominant Mn in the X, M1 and M2 sites of the general jahnsite-group formula XM1(M2)2(M3)2(H2O)8(OH)2(PO4)4. A review of published crystallochemical data for jahnsite-group minerals shows a consistent chemical pressure effect in these minerals, manifested as a contraction of the unit-cell parameter, a, as the mean size of the X and M1 site cations increases. This is analogous to negative thermal expansion, but with increasing cation size, rather than heating, inducing octahedral rotations that result in an anisotropic contraction of the unit cell.
Origins of bloodstream infections following fecal microbiota transplantation: a strain-level analysis
Authors: Eshel Adi , Sharon Itai , Nagler Arnon , Bomze David , Danylesko Ivetta , Fein Joshua A. , Geva Mika , Henig Israel , Shimoni Avichai , Zuckerman Tsila , Youngster Ilan , Koren Omry , Shouval Roni 
Published: October 2021

Abstract
We observed high rates of bloodstream infections (BSIs) following fecal microbiota transplantation (FMT) for graft-versus-host-disease (33 events in 22 patients). To trace the BSIs' origin, we applied a metagenomic bioinformatic pipeline screening donor and recipient stool samples for bacteremia-causing strains in 13 cases. Offending strains were not detected in FMT donations. Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii could be detected in stool samples before emerging in the blood. In this largest report of BSIs post-FMT, we present an approach that may be applicable for evaluating BSI origin following microbiota-based interventions. Our findings support FMT safety in immunocompromised patients but do not rule out FMT as an inducer of bacterial translocation.
Human mesenchymal stem cells derived exosomes inhibit the growth of acute myeloid leukemia cells via regulating miR-23b-5p/TRIM14 pathway
Authors: Cheng Hui , Ding Jie , Tang Gusheng , Huang Aijie , Gao Lei , Yang Jianmin , Chen Li 
Published: October 2021

Abstract
Background
Acute myeloid leukemia (AML) is a malignancy commonly seen in adults. Previous studies indicated that TRIM14 played a tumorigenic role in various types of cancer and miR-23b-5p was down-regulated in human mesenchymal stem cell-derived exosomes (HMSC-exos) of AML patients. However, their roles in AML remains unclear. Our study aims to investigate the role of TRIM14 and miR-23b-5p in the pathogenesis of AML.

Materials and methods
The blood specimen was collected from de novo AML patients and healthy donators. Exosomes were extracted from the culture medium of human mesenchymal stem cells under ultracentrifugation. Then exosomes were co-cultured with AML cells to determine the effect of their contents. The cell proliferation was detected by cell counting kit-8 assay, whereas the cell apoptosis was detected by flow cytometry. The expression of miR-23b-5p and TRIM14 was silenced or overexpressed to explore their biological functions in AML. Luciferase reporter assay was conducted to validate the interaction between miR-23b-5p and TRIM14. Gene expression was determined by quantitative real-time PCR and immunoblots.

Results
TRIM14 was significantly increased in AML patients and cell lines. The inhibition of TRIM14 significantly reduced the proliferation and induced the apoptosis of AML cells via activating PI3K/AKT pathway, whereas its overexpression exhibited reversed effects. HMSC-exos could suppress the proliferation of AML cells through the delivery of miR-23b-5p. Moreover, miR-23b-5p inhibited the transcription of TRIM14 by binding on its 3’UTR region. Overexpression of TRIM14 exhibited reversed effect against the function of miR-23b-5p mimic.

Conclusion
TRIM14 could promote the proliferation of AML cells via activating PI3K/AKT pathway, which was reversed by HMSC-exos through delivering miR-23b-5p. These findings indicated that miR-23b-5p and TRIM14 could be applied as potential targets for the treatment of AML.