bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pomelo fruit wastes are potentially valuable antioxidants, anti-inflammatories, antihypertensives, and antihyperglycemics
Authors: Lin Li-Yun , Huang Chi-Yun , Chen Kuan-Chou , Peng Robert Y. 
Published: February 2021

AbstractGrapefruit (G) parts contain abundant phenolic acids and flavonoids (PPNs and FLVs). The wastes created from exocarps, mesocarps (G wastes, GW) and waste blanching water (WBW) lead to a considerable loss of PPNs and FLVs. Here, we assessed Buntan (CB), Buntan Hayata (CBH), and Peiyu (CP) cultivars and observed considerable amounts of PPNs and FLVs. The ethanolic extracts of GW (GWE) and WBW contained gallic acid, protocatechuic acid, chlorogenic acid, caffeic acid, ferulic acid, coumaric acid, naringin, hesperidin, diosmin, quercetin, hesperetin, nobiletin, and tangeretin (GWC). GWE has previously been reported to be a relatively active antioxidant, anti-inflammatory (based on the expression of TNF-α in Raw264.7 cells), antihypertensive, and anti-hyperglycemic compound. The IC50 values for antihyperglycemic activity with WBW for α-amylase were as follows: CB (27.96 ± 0.03 mg/mL) < CP (28.13 ± 0.19 mg/mL) < CBH (41.60 ± 0.16 mg/mL), and those for α-glucosidase were CB (1.80 ± 0.03 mg/mL) < CP (2.97 ± 0.29 mg/mL) < CBH (9.10 ± 0.51 mg/mL). GWC upregulated Glut4 in HepG2 cells, as well as the insulin secretion capability, and intracellular levels in RIN-m5F cells, and it downregulated DPP4 in HepG2 cells. The IC50 values for the angiotensin-converting enzyme activity were: CBP (5.10 ± 0.02 mg/mL) < CB (7.24 ± 0.65 mg/mL) < CP (8.60 ± 2.03 mg/mL). Our results indicate that PPNs and FLVs present in GW are worth reclaiming.
Asymptotic expansions for certain exponential-type operators connected with $$2x^{3/2}$$
Authors: Abel Ulrich , Gupta Vijay , Kushnirevych Vitaliy 
Published: February 2021

AbstractIn the present paper, we consider the complete asymptotic expansion of certain exponential-type operators connected with $$2x^{3/2}$$

2

x

3
/
2

. Also, a modification of such exponential-type operators is provided, which preserve the function $$\mathrm{e}^{Ax}$$

e

Ax

.
A Diachronic Triangular Perspective on Landscapes: a Conceptual Tool for Research and Management Applied to Wadden Sea Salt Marshes
Authors: Schepers Mans , Meijles Erik W. , Bakker Jan P. , Spek Theo 
Published: February 2021

AbstractStrong disciplinary academic fragmentation and sectoral division in policies lead to problems regarding the management of landscapes. As a result, there is a focus on the preservation and development of either cultural or natural landscapes. We argue that framing landscapes as “natural” or “cultural” will not help sustainable management. The goal of this paper is to show that even what is referred to as nature, virtually always features an intricate combination of physical geography, biology, and cultural history. It provides an analytical framework that visualizes the three forces at play in physical landscapes. Therefore, we introduce a diachronic triangular approach to study and manage landscapes from a holistic point of view, allowing an exchange of different perspectives. To test this approach, we have applied our model to a diachronic case study on Wadden Sea salt marshes. That area has been influenced by physical-geographical, biological, and cultural landscape forces, which are still visible in the landscape to a large extent. By placing different landscape zones in the triangular concept for different time periods, we can identify and visualize these driving forces through time for this specific landscape. These all play their specific roles in the appearance of the landscape over time in a close mutual interconnection. More importantly, we show that the diverse and complex interplay between these forces makes the current-day landscape what it is. We therefore conclude that the diachronic triangular approach provides a conceptual tool to define and operationalize landscape management in the Wadden Sea area. We welcome similar approaches in other landscapes to assess the usefulness of the diachronic triangular landscape approach.
Influence of DE-cluster refinement on numerical analysis of rockfall experiments
Authors: Sautter Klaus Bernd , Hofmann Helene , Wendeler Corinna , Wüchner Roland , Bletzinger Kai-Uwe 
Published: February 2021

AbstractA numerical analysis is validated against a Swiss Federal Commission for Technology and Innovation (CTI)—frame impact experiment conducted by the Swiss Company Geobrugg. The discrete element method is used to simulate the impacting object, while the highly nonlinear structural response is analysed with the finite element method. Both methods are coupled within an open-source multi-physics research code to exchange data and simulate the interaction. The successful practical application of the coupling algorithm is demonstrated with this work, as the numerical results show good agreement with the experimental results. Within this paper the main focus is the appropriate modelling of the impacting objects, which heavily influences the simulation results, while a simplified structural model allows a correct assessment of the global deformation behaviour and reaction forces.
Eculizumab use in a tertiary care nephrology center: data from the Vienna TMA cohort
Authors: Aigner Christof , Gaggl Martina , Stemer Gunar , Eder Michael , Böhmig Georg , Kain Renate , Prohászka Zoltán , Garam Nóra , Csuka Dorottya , Sunder-Plassmann Raute , Piggott Leah Charlotte , Haninger-Vacariu Natalja , Schmidt Alice , Sunder-Plassmann Gere 
Published: February 2021

Abstract
Background
Practice patterns of eculizumab use are not well described. We examined indications for, and outcomes of, eculizumab therapy in a tertiary care nephrology center.

Methods
We used the “Vienna TMA cohort” and the hospital pharmacy database at the Medical University of Vienna to identify patients that received eculizumab treatment between 2012 and 2019. We describe clinical characteristics, details of eculizumab use, and outcomes of patients with complement gene-variant mediated TMA (cTMA), secondary TMA (sTMA) and C3 glomerulopathy (C3G).

Results
As of December 2019, 23 patients received complement blockade at the Division of Nephrology and Dialysis: 15 patients were diagnosed with cTMA, 6 patients with sTMA and 2 patients with C3G. Causes of sTMA were bone marrow transplantation (n = 2), malignant hypertension, malignant tumor, systemic lupus erythematosus, antiphospholipid syndrome and lung transplantation (each n = 1). Across all indications, patients had a median age of 31 and were predominantly female (78%) and the median duration of treatment was 227 days. Hematological recovery was seen in most patients, while renal response was best in patients with cTMA. Adverse events were recorded in 26%.

Conclusions
In summary, eculizumab is the treatment of choice for cTMA patients that do not respond to plasma therapy. In patients with sTMA and C3G, the response rates to therapy are much lower and therefore, the decision to start therapy needs to be considered carefully.

Graphic abstract
Hybrid structures applied to ideals in near-rings
Authors: Elavarasan B. , Muhiuddin G. , Porselvi K. , Jun Y. B. 
Published: February 2021

AbstractHuman endeavours span a wide spectrum of activities which includes solving fascinating problems in the realms of engineering, arts, sciences, medical sciences, social sciences, economics and environment. To solve these problems, classical mathematics methods are insufficient. The real-world problems involve many uncertainties making them difficult to solve by classical means. The researchers world over have established new mathematical theories such as fuzzy set theory and rough set theory in order to model the uncertainties that appear in various fields mentioned above. In the recent days, soft set theory has been developed which offers a novel way of solving real world issues as the issue of setting the membership function does not arise. This comes handy in solving numerous problems and many advancements are being made now-a-days. Jun introduced hybrid structure utilizing the ideas of a fuzzy set and a soft set. It is to be noted that hybrid structures are a speculation of soft set and fuzzy set. In the present work, the notion of hybrid ideals of a near-ring is introduced. Significant work has been carried out to investigate a portion of their significant properties. These notions are characterized and their relations are established furthermore. For a hybrid left (resp., right) ideal, different left (resp., right) ideal structures of near-rings are constructed. Efforts have been undertaken to display the relations between the hybrid product and hybrid intersection. Finally, results based on homomorphic hybrid preimage of a hybrid left (resp., right) ideals are proved.
Human–AI collaborative decision-making as an organization design problem
Authors: Puranam Phanish 
Published: February 2021

AbstractThe promise of collaboration between humans and algorithms in producing good decisions is stimulating much experimentation. Drawing on research in organization design can help us to approach this experimentation systematically. I propose typologies for considering different forms of division of labor between human and algorithm as well as the learning configurations they are arranged in, as basic building blocks for this endeavor.
The ethics of regenerative medicine
Authors: Hermerén Göran 
Published: February 2021

AbstractMost developments in regenerative medicine have in common that there are many uncertainties and knowledge gaps. These features make the evaluation of long-term consequences of the available options difficult and have consequences for the ethical issues raised. This paper presents an overview of ethical issues raised in regenerative medicine, using as a starting point a list of stakeholders and their interests. Ethical issues are introduced via a simplified account of a project that focuses on several difficult problems, as well as a conceptual framework consisting of the following key concepts: present situation, goals, difficulties on the road toward the goals, and strategies for dealing with the difficulties. The list of ethical issues discussed includes safety and efficacy, patient consent, information, professional responsibilities, as well as equity and fairness. The issues and the underlying values need to be clarified, specified, debated, and ranked in order of importance. A particular problem is that values sometimes clash: Certain values can be achieved only at the expense of others. If and when values clash, principles are available that can guide the decision making. The paper comments on two such principles with implications for the particular issue of patient access to experimental treatments: the precautionary principle and the principle of proportionality. The paper ends with some conclusions for the future.
On the Linear Integration of Attraction Choice Models in Business Optimization Problems
Authors: Bechler Georg , Steinhardt Claudius , Mackert Jochen 
Published: February 2021

AbstractDecision problems from various fields (e.g., assortment optimization, product line selection, location planning) require to endogenously incorporate probabilistic choice behavior in dependence of the availability of given choice alternatives. A widely spread demand model in marketing and econometrics to represent such choices is the attraction choice model. Of this model, the well-known multinomial logit model and—in case of multiple latent customer segments—the finite-mixture logit model are special cases. However, integrating such models in optimization problems results in non-linear formulations. Thus, in recent years, several exact linearization approaches have been proposed. These approaches are based on different ideas, and they have appeared independently from each other in different fields of research. Thus, the question arises how these approaches differ and how they relate to each other. In this short communication, we settle this question by arguing that many of the proposed approaches—even though they might seem different at first glance—can be traced back to one of two underlying linearization ideas. Establishing a generic problem, we discuss the two ideas in a unified way by presenting two corresponding general model formulations that are shown to be equivalent. Based upon this, we are able to classify the major publications which integrate some type of attraction choice model in detail. In particular, for each formulation of the analyzed literature, we explain to which extent it is a special case of (one of) the presented generic formulations. This also makes clear under which context-specific conditions certain elements of the generic linearization can be omitted, potentially serving as helpful guideline for future applications of such linearizations.
Challenges in design process of gear micropump from plastics
Authors: Rodionov L. , Stryczek J. , Rekadze P. , Stryczek P. , Gafurov S. , Prokofiev A. , Shakhmatov E. 
Published: February 2021

Abstract
Plastics are more and more frequently applied in the construction of hydraulic components and systems, and recently, in the building of microhydraulic assemblies. The basic unit of the microhydraulic systems is a micropump. It is an object which is quite difficult to design and manufacture, especially when using plastics. The paper is a presentation of challenges that must be met in the process of designing gear pumps, and, at the same time, of the theoretical grounds for the designing of those objects. The challenges include the geometry and the gears, the construction of the pump body, the hydraulics of the pump, and the material—the plastic of which the pump is made. The knowledge on those issues was applied to make and to successfully test a prototype of a micropump.
Low sun exposure habits is associated with a dose-dependent increased risk of hypertension: a report from the large MISS cohort
Authors: Lindqvist Pelle G. , Landin-Olsson M. , Olsson H. 
Published: February 2021

AbstractIn prospective observational cohort studies, increasing sun exposure habits have been associated with reduced risk of cardiovascular mortality. Our aim was to assess possible observational mechanisms for this phenomenon. A written questionnaire was answered by 23,593 women in the year 2000 regarding risk factors for melanoma, including factors of possible interest for hypertension, such as detailed sun exposure habits, hypertension, marital status, education, smoking, alcohol consumption, BMI, exercise, and chronic high stress. Hypertension was measured by the proxy “use of hypertension medication” 2005–2007, and high stress by “need of anti-depressive medication”. Sun exposure habits was assessed by the number of `yes’ to the following questions; Do you sunbath during summer?, During winter vacation?, Do you travel south to sunbath?, Or do you use sun bed? Women answering ‘yes’ on one or two questions had moderate and those answering ‘yes’ on three or four as having greatest sun exposure. The main outcome was the risk of hypertension by sun exposure habits adjusted for confounding. As compared to those women with the greatest sun exposure, women with low and moderate sun exposure were at 41% and 15% higher odds of hypertension (OR 1.41, 95% CI 1.3‒1.6, p < 0.001 and OR 1.15, 95% CI 1.1‒1.2, p < 0.001), respectively. There was a strong age-related increased risk of hypertension. Other risk factors for hypertension were lack of exercise (OR 1.36), a non-fair phenotype (OR 1.08), chronic high stress level (OR 1.8), and lack of university education (OR 1.3). We conclude that in our observational design sun exposure was associated with a dose-dependent reduced risk of hypertension, which might partly explain the fewer deaths of cardiovascular disease with increasing sun exposure.
Impact of coronavirus disease 2019 (COVID-19) on US Hospitals and Patients, April–July 2020
Authors: Sapiano Mathew R. P. , Dudeck Margaret A. , Soe Minn , Edwards Jonathan R. , O’Leary Erin N. , Wu Hsiu , Allen-Bridson Katherine , Amor Agasha , Arcement Rashad , Chernetsky Tejedor Sheri , Dantes Ray , Gross Cindy , Haass Kathryn , Konnor Rebecca , Kroop Seth R. , Leaptrot Denise , Lemoine Kent , Nkwata Allan , Peterson Kelly , Wattenmaker Lauren , Weiner-Lastinger Lindsey M. , Pollock Daniel , Benin Andrea L. ,   the NHSN Hospital COVID-19 Team
Published: February 2021

AbstractObjective:The rapid spread of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) throughout key regions of the United States in early 2020 placed a premium on timely, national surveillance of hospital patient censuses. To meet that need, the Centers for Disease Control and Prevention’s National Healthcare Safety Network (NHSN), the nation’s largest hospital surveillance system, launched a module for collecting hospital coronavirus disease 2019 (COVID-19) data. We present time-series estimates of the critical hospital capacity indicators from April 1 to July 14, 2020.Design:From March 27 to July 14, 2020, the NHSN collected daily data on hospital bed occupancy, number of hospitalized patients with COVID-19, and the availability and/or use of mechanical ventilators. Time series were constructed using multiple imputation and survey weighting to allow near–real-time daily national and state estimates to be computed.Results:During the pandemic’s April peak in the United States, among an estimated 431,000 total inpatients, 84,000 (19%) had COVID-19. Although the number of inpatients with COVID-19 decreased from April to July, the proportion of occupied inpatient beds increased steadily. COVID-19 hospitalizations increased from mid-June in the South and Southwest regions after stay-at-home restrictions were eased. The proportion of inpatients with COVID-19 on ventilators decreased from April to July.Conclusions:The NHSN hospital capacity estimates served as important, near–real-time indicators of the pandemic’s magnitude, spread, and impact, providing quantitative guidance for the public health response. Use of the estimates detected the rise of hospitalizations in specific geographic regions in June after they declined from a peak in April. Patient outcomes appeared to improve from early April to mid-July.
Coronavirus disease 2019 (COVID-19) pandemic, central-line–associated bloodstream infection (CLABSI), and catheter-associated urinary tract infection (CAUTI): The urgent need to refocus on hardwiring prevention efforts
Authors: Fakih Mohamad G. , Bufalino Angelo , Sturm Lisa , Huang Ren-Huai , Ottenbacher Allison , Saake Karl , Winegar Angela , Fogel Richard , Cacchione Joseph 
Published: February 2021

AbstractBackground:The coronavirus disease 2019 (COVID-19) pandemic has had a considerable impact on US hospitalizations, affecting processes and patient population.Objective:To evaluate the impact of COVID-19 pandemic on central-line–associated bloodstream infections (CLABSIs) and catheter associated urinary tract infections (CAUTIs) in hospitals.Methods:We performed a retrospective study of CLABSIs and CAUTIs in 78 US 12 months before COVID-19 and 6 months during COVID-19 pandemic.Results:During the 2 study periods, there were 795,022 central-line days and 817,267 urinary catheter days. Compared to the period before the COVID-19 pandemic, CLABSI rates increased by 51.0% during the pandemic period from 0.56 to 0.85 per 1,000 line days (P < .001) and by 62.9% from 1.00 to 1.64 per 10,000 patient days (P < .001). Hospitals with monthly COVID-19 patients representing >10% of admissions had a National Health Safety Network (NHSN) device standardized infection ratio for CLABSI that was 2.38 times higher than hospitals with <5% prevalence during the pandemic period (P = .004). Coagulase-negative Staphylococcus CLABSIs increased by 130% from 0.07 to 0.17 events per 1,000 line days (P < .001), and Candida spp by 56.9% from 0.14 to 0.21 per 1,000 line days (P = .01). In contrast, no significant changes were identified for CAUTI (0.86 vs 0.77 per 1,000 catheter days; P = .19).Conclusions:The COVID-19 pandemic was associated with substantial increases in CLABSIs but not CAUTIs. Our findings underscore the importance of hardwiring processes for optimal line care and regular feedback on performance to maintain a safe environment.
Maternal vitamin B12 status in early pregnancy and its association with birth outcomes in Canadian mother–newborn Dyads
Authors: Tan Amy , Sinclair Graham , Mattman Andre , Vallance Hilary D. , Lamers Yvonne 
Published: February 2021

AbstractVitamin B12 (B12) is a co-enzyme essential for fetal growth and development. Lower maternal B12 status has been associated with preterm birth (<37 gestational weeks) and low birth weight (<2500 g), which are linked to morbidity and mortality across the lifespan. In Canada, 17–25 % of women in early pregnancy had a serum total B12 concentration <148 pmol/l and maternal total B12 concentration decreased throughout pregnancy. This study aimed to determine the association between maternal B12 status and birth outcomes in Canadian mother–newborn dyads. A secondary analysis of 709 mother–newborn dyads in British Columbia (BC), Canada, was conducted. Bio-banked first- (n 656) and second-trimester (n 709) maternal serum samples of apparently healthy South Asian (50 %) and European (50 %) women from the BC Prenatal Genetic Screening Program were quantified for B12 biomarkers (total B12, holotranscobalamin (holoTC), methylmalonic acid (MMA) and total homocysteine (tHcy)). Obstetric history and birth outcome data were obtained from the BC Perinatal Data Registry. All associations were determined using multiple linear regression. Maternal serum total B12, holoTC, MMA and tHcy had a mean weekly decrease of 3·64 pmol/l, 1·04 pmol/l, 1·44 nmol/l and 0·104 μmol/l, respectively (P < 0·001). Despite a total B12 concentration <148 pmol/l among 20–25 % of the women, maternal B12 biomarker concentrations were not associated with birth weight z-score, head circumference z-score and gestational age at birth (P > 0·05). Additional research in women at high risk of adverse birth outcomes and the association between maternal B12 status and functional, for example, cognitive, outcomes is needed.
Using stakeholder’s perspectives of ‘Managed Access’ to guide management efforts in small-scale fisheries
Authors: Bowman Chad A , Mangi Stephen C , Oxenford Hazel A 
Published: February 2021

SummaryControlling and monitoring fishing effort and understanding human perspectives on fisheries management strategies are paramount to the successful management and sustainability of fisheries. Open-access fishing, which is commonplace in the small-scale fisheries (SSFs) of developing countries, poses severe challenges to management, and to address many of these challenges, Belize implemented a country-wide rights-based fishery (RBF) management strategy known as Managed Access (MA). This study uses Q methodology to explore the perspectives of four key stakeholder groups on the early impacts of the strategy, revealing five distinct perspectives. Perspective 1 supported MA but believed some components needed revision. Perspective 2 had high confidence in MA and expected improvements with financial investments. Perspective 3 did not believe in the strategy and expressed frustration with it not protecting fishers’ rights. Perspective 4 captured the biological concerns not addressed by the strategy, while Perspective 5 focused on the strategy’s inability to make the fisheries more profitable thus far. The different perspectives indicate that MA will be unlikely to meet its objectives without more financial investment in enforcement and stakeholder engagement, research and the strengthening of institutional capacity. This study contributes to the scarce scientific information on the early stages of RBF systems implementation in SSFs.