bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unusual shallow water Devonian coral community from Queensland and its recent analogues from the inshore Great Barrier Reef
Authors: Zapalski Mikołaj K. , Baird Andrew H. , Bridge Tom , Jakubowicz Michał , Daniell James 
Published: February 2021

AbstractPalaeozoic coral communities were dominated by two extinct coral groups: Tabulata and Rugosa. Whilst they are not closely related to modern Scleractinia, they are morphologically convergent, displaying many morphological characters that allow comparisons between recent and ancient coral reef communities. The extensive shallow-water reef communities of the Devonian were generally dominated by stromatoporoid sponges, with corals occupying deeper environments. Here, we describe an unusual, shallow water coral reef community from the Middle Devonian (Givetian, approx. 385 Ma) of the Fanning River area, Queensland, Australia. The coral community is dominated by tabulate corals, but also includes solitary and occasionally colonial rugose corals. Tabulate corals most commonly exhibit foliose and massive morphologies, but encrusting and branching growth forms also occur. The depositional environment was characterized by a shallow water depth, moderate hydrodynamic energy, high sedimentation rate, and high turbidity. Since these environmental factors influence the morphological composition of modern coral communities, we hypothesize that similar environments may result in morphologically equivalent coral assemblages throughout the Phanerozoic. To test this idea, we qualitatively compare the Fanning River reefs with modern scleractinian coral assemblages in a similar environmental setting at Magnetic Island. Both reefs are located in a shallow water less than 10 m deep, with high sediment flux, moderate wave energy, and generally high turbidity. Like Fanning River, Magnetic Island coral communities are dominated by foliose morphologies, with contributions from massive and branching forms. The Fanning River reef, together with previously identified Silurian and Devonian mesophotic coral ecosystems, suggest that Palaeozoic coral assemblages may share many functional characteristics with modern scleractinian reefs in similar environments. Therefore, the geological record of inshore, high turbidity-adapted coral communities can be traced back as far as 385 Ma.
Quantifying the influence of natural climate variability on in situ measurements of seasonal total and extreme daily precipitation
Authors: Risser Mark D. , Wehner Michael F. , O’Brien John P. , Patricola Christina M. , O’Brien Travis A. , Collins William D. , Paciorek Christopher J. , Huang Huanping 
Published: February 2021

AbstractWhile various studies explore the relationship between individual sources of climate variability and extreme precipitation, there is a need for improved understanding of how these physical phenomena simultaneously influence precipitation in the observational record across the contiguous United States. In this work, we introduce a single framework for characterizing the historical signal (anthropogenic forcing) and noise (natural variability) in seasonal mean and extreme precipitation. An important aspect of our analysis is that we simultaneously isolate the individual effects of seven modes of variability while explicitly controlling for joint inter-mode relationships. Our method utilizes a spatial statistical component that uses in situ measurements to resolve relationships to their native scales; furthermore, we use a data-driven procedure to robustly determine statistical significance. In Part I of this work we focus on natural climate variability: detection is mostly limited to DJF and SON for the modes of variability considered, with the El Niño/Southern Oscillation, the Pacific–North American pattern, and the North Atlantic Oscillation exhibiting the largest influence. Across all climate indices considered, the signals are larger and can be detected more clearly for seasonal total versus extreme precipitation. We are able to detect at least some significant relationships in all seasons in spite of extremely large (> 95%) background variability in both mean and extreme precipitation. Furthermore, we specifically quantify how the spatial aspect of our analysis reduces uncertainty and increases detection of statistical significance while also discovering results that quantify the complex interconnected relationships between climate drivers and seasonal precipitation.
Treatment of advanced stage osteochondrosis dissecans in the adolescent elbow using a hyaloronic acid-based scaffold: a case series of 5 patients
Authors: Farr Sebastian , Pallamar Matthias , Eder Theresa , Ganger Rudolf 
Published: February 2021

Abstract
Introduction
Osteochondrosis dissecans (OCD) is considered to be one of the main causes for pain, discomfort and morbidity in the pediatric elbow joint. Few treatment options, such as microfracture or autologous transplantation, of osteochondral bone grafts have been described to address advanced OCD. The aim of this retrospective case series is to present preliminary clinical and radiologic findings following advanced stage OCD repair using a novel combination of a hyaluronic acid-based scaffold with autologous iliac crest bone grafting.

Materials and methods
Five adolescents, who underwent treatment of OCD (grade 3 or 4 according to Nelson) using a combination technique of defect debridement, transplantation of cancellous iliac crest bone and application of a HYALOFAST® membrane (Anika Therapeutics S.r.L., Italy), were re-assessed using clinical and radiologic examinations (defect diameter, depth, sclerosis, congruency, fragmentation, dissection, radiolucency, growth plate status; MRI) after a minimum of 2 years (mean, 34 months; range, 24–45) postoperatively. Dedicated outcome scores (Numeric Rating Scale [NRS], Pediatric Outcome Data Collection Instrument [PODCI], Mayo Elbow Performance Score [MEPS], and Timmerman-Andrews Score [TIMM] were collected.

Results
All patients reported a NRS score of 0. The mean total TIMM, MEPS and PODCI (Global Functioning Scale) scores were 189 (range 165–200), 94 (range, 70–100), and 92 (range 83–98; normative score 47; range 35–55), respectively, indicating good to excellent clinical outcomes. The radiographic analysis showed overall improvements with regard to OCD width and depth reduction (35%, − 27–100%; 52%, 4–100%), but full resolution in only 2 of 5 cases. Elbow motion improved slightly after surgery. No complications were noted.

Conclusion
This study showed promising clinical short- to mid-term results in adolescent patients with advanced OCD using a novel surgical treatment combination. Radiographic results showed partial healing; hence, residual changes should be monitored over a longer period.
Effects of tranexamic acid on human nasal ciliary beat frequency
Authors: Behr W. , Horschke F. , Nastev A. , Mueller C. E. , Sommer J. U. , Folz B. , Li H. , Geisthoff U. W. , Stuck B. A. , Birk R. 
Published: February 2021

Abstract
Background
Patients with recurrent epistaxis, particularly due to hereditary hemorrhagic telangiectasia (HHT) are recommended to apply topical tranexamic acid (TXA) to reduce bleeding events. Those patients may suffer ciliary dysfunction due to TXA’s effects on ciliary beating frequency (CBF) and their consequences.

Methodology/principal
Human nasal epithelial cells were harvested with a nasal brush in 30 healthy subjects. We investigated the CBF in RPMI medium using high-frequency video microscopy. TXA was added to the cells in various concentrations ranging from 2 to 5%, including the therapeutic concentration (2%) and a control (0%).

Results
CBF in the control condition was 6.1 ± 1.6 Hz. TXA reduces CBF in a time and concentration dependent manner, to, e.g. 4.3 ± 1.2 Hz with 2% TXA and 3.3 ± 0.9 Hz with 5% TXA after 16–20 min. The differences in CBF were statistically significant for all concentrations of TXA.

Conclusions
TXA has the potential to significantly impair nasal epithelial function. Therefore, frequent or regular topical nasal application of TXA should be done under close monitoring of nasal function, especially in patients with co-morbidities like chronic rhinosinusitis.
A 25-year retrospective, single center analysis of 343 WHO grade II/III glioma patients: implications for grading and temozolomide therapy
Authors: Steidl Eike , Filipski Katharina , Zeiner Pia S. , Wagner Marlies , Fokas Emmanouil , Forster Marie-Therese , Ronellenfitsch Michael W. , Divé Iris , Steinbach Joachim P. , Harter Patrick N. , Bähr Oliver 
Published: February 2021

Abstract
Purpose
Classification and treatment of WHO grade II/III gliomas have dramatically changed. Implementing molecular markers into the WHO classification raised discussions about the significance of grading and clinical trials showed overall survival (OS) benefits for combined radiochemotherapy. As molecularly stratified treatment data outside clinical trials are scarce, we conducted this retrospective study.

Methods
We identified 343 patients (1995–2015) with newly diagnosed WHO grade II/III gliomas and analyzed molecular markers, patient characteristics, symptoms, histology, treatment, time to treatment failure (TTF) and OS.

Results
IDH-status was available for all patients (259 mutant, 84 IDH1-R132H-non-mutant). Molecular subclassification was possible in 173 tumors, resulting in diagnosis of 80 astrocytomas and 93 oligodendrogliomas. WHO grading remained significant for OS in astrocytomas/IDH1-R132H-non-mutant gliomas (p < 0.01) but not for oligodendroglioma (p = 0.27). Chemotherapy (and temozolomide in particular) showed inferior OS compared to radiotherapy in astrocytomas (median 6.1/12.1 years; p = 0.03) and oligodendrogliomas (median 13.2/not reached (n.r.) years; p = 0.03). While radiochemotherapy improved TTF in oligodendroglioma (median radiochemotherapy n.r./chemotherapy 3.8/radiotherapy 7.3 years; p < 0.001/ = 0.06; OS data immature) the effect, mainly in combination with temozolomide, was weaker in astrocytomas (median radiochemotherapy 6.7/chemotherapy 2.3/radiotherapy 2.0 years; p < 0.001/ = 0.11) and did not translate to improved OS (median 8.4 years).

Conclusion
This is one of the largest retrospective, real-life datasets reporting treatment and outcome in low-grade gliomas incorporating molecular markers. Current histologic grading features remain prognostic in astrocytomas while being insignificant in oligodendroglioma with interfering treatment effects. Chemotherapy (temozolomide) was less effective than radiotherapy in both astrocytomas and oligodendrogliomas while radiochemotherapy showed the highest TTF in oligodendrogliomas.
HER2 copy number as predictor of disease-free survival in HER2-positive resectable gastric adenocarcinoma
Authors: Liu Zimin , Shi Mingpeng , Li Xiaoxiao , Song Shanai , Liu Ning , Du Haiwei , Ye Junyi , Li Haiyan , Zhang Zhou , Zhang Lu 
Published: February 2021

Abstract
Purpose
The identification of HER2 overexpression in a subset of gastric adenocarcinoma (GA) patients represents a significant step forward in unveiling the molecular complexity of this disease. The predictive and prognostic value of HER2 amplification in advanced HER2 inhibitor-treated GA patients has been investigated. However, its predictive value in resectable patients remains elusive.

Methods
We enrolled 98 treatment-naïve resectable Chinese GA patients with HER2 overexpression assessed using IHC. Capture-based targeted sequencing using a panel consisting of 41 gastrointestinal cancer-related genes was performed on tumor tissues. Furthermore, we also investigated the correlation between HER2 copy number (CN) and survival outcomes.

Results
Of the 98 HER2-overexpressed patients, 90 had HER2 CN amplification assessed using next-generation sequencing, achieving 92% concordance. The most commonly seen concurrent mutations were occurring in TP53, EGFR and PIK3CA. We found HER2 CN as a continuous variable was an independent predictor associated with DFS (p = 0.029). Our study revealed HER2 CN-high patients showed a trend of intestinal-type GA predominant (p = 0.075) and older age (p = 0.07). The median HER2 CN was 15.34, which was used to divide the cohort into CN-high and CN-low groups. Patients with high HER2 CN had a significantly shorter DFS than patients with low HER2 CN (p = 0.002). Furthermore, HER2 CN as a categorical variable was also an independent predictor associated with DFS in patients.

Conclusion
We elucidated the mutation spectrum of HER2-positive resectable Chinese GA patients and the association between HER2 CN and DFS. Our work revealed HER2 CN as an independent risk factor predicted unfavorable prognosis in HER2-positive GA patients and allowed us to further stratify HER2-positive resectable GA patients for disease management.
Treatment stage migration and treatment sequences in patients with hepatocellular carcinoma: drawbacks and opportunities
Authors: Wehling Cyrill , Dill Michael T. , Olkus Alexander , Springfeld Christoph , Chang De-Hua , Naumann Patrick , Longerich Thomas , Kratochwil Clemens , Mehrabi Arianeb , Merle Uta , Pfeiffenberger Jan , Rupp Christian , Weiss Karl Heinz , Mieth Markus 
Published: February 2021

Abstract
Purpose
This retrospective analysis focuses on treatment stage migration in patients with hepatocellular carcinoma (HCC) to identify successful treatment sequences in a large cohort of real-world patients.

Methods
1369 HCC patients referred from January 1993 to January 2020 to the tertiary center of the Heidelberg University Hospital, Germany were analyzed for initial and subsequent treatment patterns, and overall survival.

Results
The most common initial treatment was transarterial chemoembolization (TACE, n = 455, 39.3%) followed by hepatic resection (n = 303, 26.1%) and systemic therapy (n = 200, 17.3%), whereas the most common 2nd treatment modality was liver transplantation (n = 215, 33.2%) followed by systemic therapy (n = 177, 27.3%) and TACE (n = 85, 13.1%). Kaplan–Meier analysis revealed by far the best prognosis for liver transplantation recipients (median overall survival not reached), followed by patients with hepatic resection (11.1 years). Patients receiving systemic therapy as their first treatment had the shortest median overall survival (1.7 years; P < 0.0001). When three or more treatment sequences preceded liver transplantation, patients had a significant shorter median overall survival (1st seq.: not reached; 2nd seq.: 12.4 years; 3rd seq.: 11.1 years; beyond 3 sequences: 5.5 years; P = 0.01).

Conclusion
TACE was the most common initial intervention, whereas liver transplantation was the most frequent 2nd treatment. While liver transplantation and hepatic resection were associated with the best median overall survival, the timing of liver transplantation within the treatment sequence strongly affected median survival.
Complement activation in children with Streptococcus pneumoniae associated hemolytic uremic syndrome
Authors: Holle Johannes , Habbig Sandra , Gratopp Alexander , Mauritsch Anna , Müller Dominik , Thumfart Julia 
Published: February 2021

Abstract
Background
Hemolytic uremic syndrome caused by invasive pneumococcal disease (P-HUS) is rare in children and adolescents, but accompanied by high mortality in the acute phase and complicated by long-term renal sequelae. Abnormalities in the alternative complement pathway may additionally be contributing to the course of the disease but also to putative treatment options.

Methods
Retrospective study to assess clinical course and laboratory data of the acute phase and outcome of children with P-HUS.

Results
We report on seven children (median age 12 months, range 3–28 months) diagnosed with P-HUS. Primary organ manifestation was meningitis in four and pneumonia in three patients. All patients required dialysis which could be discontinued in five of them after a median of 25 days. In two patients, broad functional and genetic complement analysis was performed and revealed alternative pathway activation and risk haplotypes in both. Three patients were treated with the complement C5 inhibitor eculizumab. During a median follow-up time of 11.3 years, one patient died due to infectious complications after transplantation. Two patients showed no signs of renal sequelae.

Conclusions
Although pathophysiology in P-HUS remains as yet incompletely understood, disordered complement regulation seems to provide a clue to additional insights for pathology, diagnosis, and even targeted treatment.
Subjective resource value affects aggressive behavior independently of resource-holding-potential and color morphs in male common wall lizard
Authors: Sacchi Roberto , Coladonato Alan J. , Battaiola Mara , Pasquariello Carlotta , Buratti Simone , Matellini Cristian , Mangiacotti Marco , Scali Stefano , Zuffi Marco A. L. 
Published: February 2021

AbstractGame theory models predict the outcome of a dyadic contest to depend on opponents’ asymmetries in three main traits: resource-holding potential (RHP), resource value (RV) and aggressiveness. Using male common wall lizards Podarcis muralis, a polymorphic species showing three discrete morphs (white, yellow, and red), we investigated how the aggressive behavior varies according to a change in subjective RV and color morphs, while controlling for the asymmetry in RHP (using mirrors). By comparing the aggression of the same individual towards its mirror image in two different arenas (familiar = high subjective RV; novel = low subjective RV), we showed that lizard aggressive behavior was more intense and prolonged in the familiar arena than in the new one, thus supporting the occurrence of a direct relationship between motivation and aggression in this species. We also found the overall aggressiveness to differ from individual to individual, supporting the general hypothesis that aggressiveness is a trait associated with personality. By contrast, no effect of morphs was detected, ruling out the occurrence of morph specific variation in the aggressiveness. Our results highlight that an individual’s motivation and personality might be as important as RHP and RV in the resolution of animal contests.
Repatterning of the inflorescence meristem in Gerbera hybrida after wounding
Authors: Zhang Teng , Wang Feng , Elomaa Paula 
Published: February 2021

AbstractThe Asteraceae plant family is characterized by inflorescences, called flower heads or capitula that may combine hundreds of individual florets into a single flower-like structure. The florets are arranged in a regular phyllotactic pattern with Fibonacci numbers of left- and right-winding spirals. Such a pattern may be disrupted due to physical constraints or by wounding occurring during the early meristem development. Recovery from wounding re-establishes patterning although the mechanisms have remained elusive. In this study, we applied Gerbera hybrida as a model system and established methods to conduct wounding experiments either with syringe needles or using laser ablation combined with live imaging of head meristems. By revisiting the historical experiments in sunflower, we conducted wounding to transgenic auxin reporter lines of gerbera and followed the recovery of cellular growth and meristem patterning. We show that wounding disrupted the expression of the gerbera CLAVATA3 (GhCLV3) gene that marks the undifferentiated meristematic region and led to de novo re-initiation of patterning at the wound margin. During the recovery growth, three to five layers of elongated cells showing periclinal cell division planes and lacking auxin signal were formed at the wound rim. DR5 auxin signal was shown to localize and form regularly spaced maxima in a distance from the wound rim. Consequently, spiral pattern of contact parastichies was re-established by stacking of new auxin maxima on top of the previous ones. The developed methods facilitate future studies on understanding the molecular mechanisms of de novo patterning of meristems.
Time-Dependent Wave Equations on Graded Groups
Authors: Ruzhansky Michael , Taranto Chiara Alba 
Published: February 2021

AbstractIn this paper we consider the wave equations for hypoelliptic homogeneous left-invariant operators on graded Lie groups with time-dependent Hölder (or more regular) non-negative propagation speeds. The examples are the time-dependent wave equation for the sub-Laplacian on the Heisenberg group or on general stratified Lie groups, or $p$
p
-evolution equations for higher order operators on ${{\mathbb{R}}}^{n}$

R
n

or on groups, already in all these cases our results being new. We establish sharp well-posedness results in the spirit of the classical result by Colombini, De Giorgi and Spagnolo. In particular, we describe an interesting local loss of regularity phenomenon depending on the step of the group (for stratified groups) and on the order of the considered operator.
Nudges in SRI: The Power of the Default Option
Authors: Gajewski Jean-Francois , Heimann Marco , Meunier Luc 
Published: February 2021

AbstractWe introduce nudges in order to incite investors to choose Socially Responsible Investment (SRI) funds instead of traditional funds. We have set up two online experiments with a total of 713 US retail investors, using three types of nudges to elicit their effects on investors’ SRI investments level: making SRI the default investment, introducing a SRI explanation message, and priming ethical values by displaying shocking images. Making SRI the default option is the most efficient nudge to influence investors towards SRI. Its effect is twofold. First, around 50% of investors do not opt-out of the default allocation. Second, even investors who opt-out of the default allocation invest more in SRI than those in the control group, an effect that appears driven by anchoring. Although investors subjected to both priming and message content marginally increase their SRI investment, priming or message content in isolation appears to have a non-significant influence. For choice architects who want to steer retail investors towards SRI funds, making them the default option appears to be the most powerful nudge.
An in-depth investigation of critical stretch based failure criterion in ordinary state-based peridynamics
Authors: Karpenko Olena , Oterkus Selda , Oterkus Erkan 
Published: February 2021

AbstractThis study presents an in-depth investigation of the critical stretch based failure criterion in ordinary state-based peridynamics for both static and dynamic conditions. Seven different cases are investigated to determine the effect of the failure parameter on peridynamic forces between material points and dilatation. Based on crack opening displacement (COD) results from both peridynamics and finite element analysis, it was found that one of the seven cases provides the best agreement between the two approaches. This particular case is further investigated by considering the influence of the discretisation and the horizon sizes on COD and crack propagation speeds. Moreover, PD predictions of COD for PMMA material is analysed with the theory of dynamic fracture mechanics and compared with the fracture experiments. It is shown that the peridynamic model can correctly model, simulate and predict the behaviour of the crack under different loading conditions. Furthermore, the presented PD models capture accurate fracture phenomena, specifically the crack path, branching angles and crack propagation speeds, which are in good agreement with experimental results.