bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why macroprudential policy matters in a monetary union
Authors: Buch Claudia M. , Buchholz Manuel , Knoll Katharina , Weigert Benjamin 
Published: June 2021

Abstract
This article discusses the role of macroprudential policy in a monetary union. It focuses on three main points. First, macroprudential policy has the objective of mitigating financial stability risks by preventing the build-up of vulnerabilities and increasing resilience. Second, many vulnerabilities reflect country-specific preferences and interact with national institutions. Monitoring and addressing financial stability risks at the national level are thus important. This holds particularly in a monetary union with economies that are highly integrated financially, but heterogeneous along important dimensions that can significantly affect financial stability risks. Third, cross-border externalities and spillovers call for the coordination of national macroprudential policies at the supranational level. This includes mechanisms to account for a potential inaction bias. Methodologically, the article draws on existing literature adding new empirical evidence on financial integration and adjustment to spillovers in the euro area.
Endoscopic Placement of Fourth Ventricular Catheter Using Seldinger Technique: Description of Technique and Case Series
Authors: Carter Lacey M , Gross Naina L 
Published: June 2021

Abstract

BACKGROUND
Neonatal intraventricular hemorrhage remains a significant source of morbidity in premature and low-weight patients. Approximately 15% of patients who require cerebrospinal fluid shunting develop trapped fourth ventricle (TFV). Surgical treatment presents challenges with short- and long-term complications.

OBJECTIVE
To describe a technique that applies the Seldinger technique with image-guided endoscopy for direct visualization of catheter placement.

METHODS
A guidewire is passed down the endoscope while it is positioned in the fourth ventricle. The endoscope is removed while the guidewire is held in place. The catheter is slid down the guidewire. The guidewire is removed and placement is confirmed with image guidance.

RESULTS
Three patients, all less than 14 mo old, with history of prematurity and intraventricular hemorrhage with ventriculoperitoneal shunts, presented with loculated hydrocephalus with TFV. They each underwent image-guided endoscopic fenestration of the fourth ventricle with placement of a fourth ventricular catheter performed by our described technique. All 3 patients recovered well and were discharged on postoperative day 1. Follow-up imaging showed decompression of the fourth ventricle and good placement of the fourth ventricular catheter. None have had complications from catheter placement, and one revision of a fourth ventricular catheter was needed, which was completed with the same described technique.

CONCLUSION
This technique is well suited for cases in which a fourth ventricular catheter or a difficult trajectory catheter is needed during endoscopic fenestration or when distorted anatomy is present that would make a straight trajectory with a pen endoscope more difficult or higher risk.
Krill diel vertical migration in Southern Patagonia
Authors: Nocera Ariadna C , Giménez Eloísa M , Diez Mariano J , Retana María Valeria , Winkler Gesche 
Published: June 2021

AbstractDiel vertical migration (DVM) of krill was studied throughout 36 h at a fixed station (46.05°S, 66.19°W; 98-m depth) located in the center of the San Jorge Gulf, Southern Patagonia area, during February 2014. Using an echosounder system, combined with an autonomous Video Plankton Recorder (Auto-VPR) and Jacknet samplings, we describe the migration pattern, the associated biomass and the macrozooplankton species involved. The net sampling and the Auto-VPR images allowed us to identify the krill species detected in the echosounder signals, which corresponded to Euphausia lucens, Euphausia vallentini and Nematoscelis megalops. The krill community followed a “normal pattern” of DVM, ascending at dusk (~18:30 h) and descending at dawn (~06:30 h), forming a dense layer near the bottom during the day. Krill vertical migration speed was estimated from the echogram data at ~ 1 cm s−1 (1 body length per s for 1-cm-long animal), and the integrated mean biomass was 57.8 g m−2. This study provides a description of temporal and spatial patterns of krill vertical distribution, which should be taken into account when studying the complexity of the SJG ecosystem dynamics and carbon flux.
Transient Reductions in Postoperative Pain and Anxiety with the Use of Virtual Reality in Children
Authors: Olbrecht Vanessa A , O’Conor Keith T , Williams Sara E , Boehmer Chloe O , Marchant Gilbert W , Glynn Susan M , Geisler Kristie J , Pickerill Hannah M , Ding Lili , Yang Gang , King Christopher D 
Published: June 2021

Abstract

Objective
Virtual reality is a promising method to manage pain. Distraction-based virtual reality (VR-D) is thought to reduce pain by redirecting attention. Although VR-D can reduce pain associated with acutely painful procedures, it is unclear whether VR-D can reduce pain after surgery. We assessed the ability of a single VR-D session to decrease postoperative pain and anxiety and explored whether pain catastrophizing and anxiety sensitivity influenced these outcomes in children after surgery.

Design
Single-center, prospective, pilot study.

Setting
Cincinnati Children’s Hospital Medical Center (CCHMC).

Subjects
Fifty children (7–21 years of age) with postoperative pain followed by the Acute Pain Service.

Methods
Patients received one VR-D session after surgery. Before the session, patients completed pain catastrophizing (Pain Catastrophizing Scale for Children) and anxiety sensitivity (Child Anxiety Sensitivity Index) questionnaires. The primary outcome consisted of changes in pain intensity after VR-D (immediately, 15 minutes, and 30 minutes). Secondary outcomes included changes in pain unpleasantness and anxiety.

Results
VR-D use was associated with a decrease in pain intensity immediately and 15 minutes after VR-D. Reductions in pain unpleasantness were observed up to 30 minutes after VR-D. VR-D was also associated with a reduction in anxiety immediately and at 15 minutes. Although patients with higher pain catastrophizing had higher baseline pain intensity and unpleasantness, they did not show larger pain reductions after VR-D than those with lower pain catastrophizing.

Conclusions
VR-D may be beneficial in transiently reducing pain intensity, unpleasantness, and anxiety in children with postoperative pain. This study informs the design of a larger, randomized, controlled study assessing VR-D for acute postoperative pain and anxiety management.
Reporting of Harm in Randomized Controlled Trials of Therapeutic Exercise for Knee Osteoarthritis: A Systematic Review
Authors: von Heideken Johan , Chowdhry Sana , Borg Joanna , James Khara , Iversen Maura D 
Published: June 2021

Abstract

Objective
The Consolidated Standards of Reporting Trials (CONSORT) recommends reporting adverse events (AEs) and dropouts (DOs) with their definitions. The purpose of this study was to identify how AEs and DOs were reported in randomized controlled trials of therapeutic exercise for knee osteoarthritis (OA).

Methods
Data sources were the Cochrane Library, Embase, PubMed, and CINAHL. Databases were searched to identify randomized controlled trials of therapeutic exercise for knee OA published from January 1, 1980, through July 23, 2020. Researchers independently extracted participant and intervention characteristics and determined whether a clear statement of and reasons for AEs and DOs existed. The primary outcome was exercise-related harm. Physiotherapy Evidence Database (PEDro) scoring described study quality and risk of bias. Descriptive and inferential statistics characterized results. Meta-analysis was not performed due to data heterogeneity.

Results
One hundred and thirteen studies (152 arms) from 25 countries were included, with 5909 participants exercising. PEDro scores ranged from 4 to 9. Exercise intensity was not specified in 57.9% of exercise arms. Fifty studies (44.2%) included an AE statement and 24 (21.2%) reported AEs, yielding 297 patients. One hundred and three studies (91.2%) had a DO statement. Sixteen studies (15.5%) provided reasons for DOs that could be classified as AEs among 39 patients, yielding a 13.1% increase in AEs. Thus, 336 patients (6.0%) experienced exercise-related harm among studies with a clear statement of AEs and DOs. A significant difference existed in misclassification of DOs pre- and post-CONSORT-2010 (12.2% vs 3.1%; $\chi^{2}_{1} = 21.2$).

Conclusions
In some studies, the reason for DOs could be considered AEs, leading to potential underreporting of harm. Improvements in reporting of harm were found pre- and post-CONSORT-2010. Greater clarity regarding AE and DO definitions and therapeutic exercise intensity are needed to determine safe dosing and mode of therapeutic exercise for knee OA.

Impact
More adherence to the CONSORT statement is needed regarding reporting of and defining of AEs, DOs, and therapeutic exercise intensity; however, despite this, therapeutic exercise seems to be associated with minimal risk of harm.
Family socioeconomic status and mental health in Chinese adolescents: the multiple mediating role of social relationships
Authors: Li Jing , Wang Jing , Li Jia-yu , Qian Sheng , Ling Rui-zhe , Jia Rui-xia , Wang Ying-quan , Xu Yong 
Published: June 2021

AbstractBackgroundThe purpose of this study is to explore whether social relationships of family and school contexts mediate the influence of socioeconomic status (SES) on Chinese adolescents’ mental health.MethodsA school-based study was conducted among a sample aged 13–18 in East China (n = 6902). We used scales for measuring social relationships and self-rated mental health. Family SES was computed from subjective socioeconomic status, education and occupation of parents.The mediation model was tested by using Path Analysis in IBM SPSS-Amos.ResultsThe results showed that SES can significantly influence adolescent mental health through parent–child relationship, student–teacher relationship and student–student relationship. The total effect, direct effect and total indirect effect were −0.209 (95% CI = −0.299, −0.136), −0.090 (95% CI = −0.174, −0.007), −0.119 (95% CI = −0.187, −0.078) for boys, and −0.337 (95% CI = −0.478, −0.230), −0.132 (95% CI = −0.283, 0.010), −0.205 (95% CI = −0.351, −0.085) for girls.ConclusionThe link between SES and adolescent mental health can be explained by social relationships. Focusing on the parent–child, student–student and student–teacher relationship interventions may contribute to improving the mental health of Chinese adolescents, especially in low socioeconomic groups, as well as female students.
Autistic Symptoms and Social Functioning in Psychosis: A Network Approach
Authors: Isvoranu Adela-Maria , Ziermans Tim , Schirmbeck Frederike , Borsboom Denny , Geurts Hilde M , de Haan Lieuwe ,   GROUP Investigators, van Amelsvoort Therese , Bartels-Velthuis Agna A , Simons Claudia J P , van Os Jim 
Published: June 2021

AbstractPsychotic and autistic symptoms are related to social functioning in individuals with psychotic disorders (PD). The present study used a network approach to (1) evaluate the interactions between autistic symptoms, psychotic symptoms, and social functioning, and (2) investigate whether relations are similar in individuals with and without PD. We estimated an undirected network model in a sample of 504 PD, 572 familial risk for psychosis (FR), and 337 typical comparisons (TC), with a mean age of 34.9 years. Symptoms were assessed with the Autism Spectrum Quotient (AQ; 5 nodes) and the Community Assessment of Psychic Experiences (CAPE; 9 nodes). Social functioning was measured with the Social Functioning Scale (SFS; 7 nodes). We identified statistically significant differences between the FR and PD samples in global strength (P &lt; .001) and network structure (P &lt; .001). Our results show autistic symptoms (social interaction nodes) are negatively and more closely related to social functioning (withdrawal, interpersonal behavior) than psychotic symptoms. More and stronger connections between nodes were observed for the PD network than for FR and TC networks, while the latter 2 were similar in density (P = .11) and network structure (P = .19). The most central items in strength for PD were bizarre experiences, social skills, and paranoia. In conclusion, specific autistic symptoms are negatively associated with social functioning across the psychosis spectrum, but in the PD network symptoms may reinforce each other more easily. These findings emphasize the need for increased clinical awareness of comorbid autistic symptoms in psychotic individuals.
Risk of sustained SARS-CoV-2 transmission in Queensland, Australia
Authors: Sanz-Leon Paula , Stevenson Nathan J. , Stuart Robyn M. , Abeysuriya Romesh G. , Pang James C. , Lambert Stephen B. , Kerr Cliff C. , Roberts James A. 
Published: June 2021

AbstractWe used an agent-based model Covasim to assess the risk of sustained community transmission of SARS-CoV-2/COVID-19 in Queensland (Australia) in the presence of high-transmission variants of the virus. The model was calibrated using the demographics, policies, and interventions implemented in the state. Then, using the calibrated model, we simulated possible epidemic trajectories that could eventuate due to leakage of infected cases with high-transmission variants, during a period without recorded cases of locally acquired infections, known in Australian settings as “zero community transmission”. We also examined how the threat of new variants reduces given a range of vaccination levels. Specifically, the model calibration covered the first-wave period from early March 2020 to May 2020. Predicted epidemic trajectories were simulated from early February 2021 to late March 2021. Our simulations showed that one infected agent with the ancestral (A.2.2) variant has a 14% chance of crossing a threshold of sustained community transmission (SCT) (i.e., > 5 infections per day, more than 3 days in a row), assuming no change in the prevailing preventative and counteracting policies. However, one agent carrying the alpha (B.1.1.7) variant has a 43% chance of crossing the same threshold; a threefold increase with respect to the ancestral strain; while, one agent carrying the delta (B.1.617.2) variant has a 60% chance of the same threshold, a fourfold increase with respect to the ancestral strain. The delta variant is 50% more likely to trigger SCT than the alpha variant. Doubling the average number of daily tests from ∼ 6,000 to 12,000 results in a decrease of this SCT probability from 43% to 33% for the alpha variant. However, if the delta variant is circulating we would need an average of 100,000 daily tests to achieve a similar decrease in SCT risk. Further, achieving a full-vaccination coverage of 70% of the adult population, with a vaccine with 70% effectiveness against infection, would decrease the probability of SCT from a single seed of alpha from 43% to 20%, on par with the ancestral strain in a naive population. In contrast, for the same vaccine coverage and same effectiveness, the probability of SCT from a single seed of delta would decrease from 62% to 48%, a risk slightly above the alpha variant in a naive population. Our results demonstrate that the introduction of even a small number of people infected with high-transmission variants dramatically increases the probability of sustained community transmission in Queensland. Until very high vaccine coverage is achieved, a swift implementation of policies and interventions, together with high quarantine adherence rates, will be required to minimise the probability of sustained community transmission.
Automatic Electrophysiological Noise Reduction and Epileptic Seizure Detection for Stereoelectroencephalography
Authors: Zhou Yufeng , You Jing , Zhu Fengjun , Bragin Anatol , Engel Jerome , Li Lin 
Published: June 2021

AbstractThe objective of this study was to develop a computational algorithm capable of locating artifacts and identifying epileptic seizures, which specifically implementing in clinical stereoelectroencephalography (SEEG) recordings. Based on the nonstationary nature and broadband features of SEEG signals, a comprehensive strategy combined with the complex wavelet transform (CWT) and multi-layer thresholding method was implemented for both noise reduction and seizure detection. The artifacts removal pipeline integrated edge artifact removal, discrete spectrum analysis, and peak density evaluation. For automatic seizure detection, integrated power analysis and multi-dynamic thresholding were applied. The F1-score was applied to evaluate overall performance of the algorithm. The algorithm was tested using expert-marked, double-blinded, clinical SEEG data from seven patients undergoing presurgical evaluation. This approach achieved the F1 score of 0.86 for noise reduction and 0.88 for seizure detection. This offline-approach method with minimum parameter tuning procedures and no prior information required, proved to be a feasible and solid solution for clinical SEEG data evaluation. Moreover, the algorithm can be improved with additional tuning and implemented with machine learning postprocessing pipelines.
Point-of-care testing in a high-income country paediatric emergency department – a qualitative study in Sweden
Authors: Rasti Reza , Brännström Johanna , Mårtensson Andreas , Zenk Ingela , Gantelius Jesper , Gaudenzi Giulia , Alvesson Helle M. , Alfvén Tobias 
Published: June 2021

ABSTRACTObjectivesIn many resource-limited health systems, point-of-care tests (POCTs) are the only means for clinical patient sample analyses. However, the speed and simplicity of POCTs also makes their use appealing to clinicians in high-income countries (HICs), despite their having greater laboratory accessibility. Although also part of the clinical routine in HICs, the utility of POCTs is relatively unknown in such settings as compared to others.In a Swedish paediatric emergency department (PED) where POCT use is routine, we aimed to characterize health care providers’ perspectives on the clinical utility of POCTs and explore their implementation in the local setting; to compare such experiences to those reported in other settings; and finally, to gather requests for ideal novel POCTs.DesignQualitative study using focus group discussions. A data-driven content analysis approach was used for analysis.SettingThe PED of a secondary paediatric hospital in Stockholm, Sweden.ParticipantsTwenty-four health care providers clinically active at the PED were enrolled in six focus groups.ResultsA range of POCTs was routinely used. The emerging themeUtility of POCTs is double-edgedillustrated the perceived utility of POCTs. While POCT services were considered to have clinical and social value, the local testing practice was named to distract from the care for patients. Requests were made for novel POCTs and their implementation.ConclusionDespite their clinical integration, deficient implementation routines limit the benefits of POCT services to this well-resourced paediatric clinic. As such deficiencies are shared with other settings, it is suggested that some characteristics of POCTs and of their utility are less related to resource level and more to policy deficiency. To address this, we propose the appointment of skilled laboratory personnel as ambassadors to hospital clinics offering POCT services, to ensure higher utility of such services.ARTICLE SUMMARYStrengths and limitations of this studyThis is the first study to present the use and utility of POCTs in a HIC paediatric hospital setting, directly from the perspective of its clinical staff.Our main finding is that deficient implementation routines limit benefit of POCT services in this well-resourced setting, strongly indicating that such deficiencies are irrespective of resource level, and more related to policy deficiency.The findings of the relatively small study size may be contextual, yet we believe our main conclusions to be generalizable as most of our findings are compatible with those reported in other settings.The study is strengthened by the diversity of its participants, corresponding to the multi-professional staffing of the PED.
Impact of COVID-19 on deaths from respiratory diseases: Panel Data evidence from Chile
Authors: Barría-Sandoval Claudia , Mendez Angie , Ferreira Guillermo , Toffoletto María Cecilia 
Published: June 2021

AbstractThe COVID-19 pandemic has left other pathologies commonly present in the population in a secondary context. Therefore, it is necessary to study the evolution of these diseases in the presence or absence of COVID-19.ObjectivesThe present study had the following objectives: 1. To evaluate the relationship between the COVID-19 epidemic and the possible decrease in deaths from respiratory diseases in Chile. 2 Study the relationship between meteorological variables and severity of COVID-19 with respect to deaths from respiratory diseases from January 2018 to February 2021.MethodsThe variable number of deaths due to respiratory diseases in Chile was analyzed considering the monthly records of meteorological variables (temperature, precipitation and humidity) in each Region of Chile and severity of COVID-19, to evaluate the mortality trend before and after the pandemic. For this, different Non-Observable Heterogeneity Models for Panel Data were usedResultsOur findings show that among the variables that affect the mortality rate from respiratory diseases, there are the number of deaths from COVID-19 that has a negative effect, the number of patients with COVID-19 in intensive care unit (ICU) that has a positive effect and the minimum temperature with a negative effect. These results are supported by the application of the panel regression with one-way random-effects models.ConclusionThis study revealed that there is an unexpected reduction in deaths from respiratory diseases in Chile in the post-pandemic period. Therefore, it can be concluded that this variable decreased with the appearance of the COVID-19 pandemic.