bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensory gating, neurocognition, social cognition and real-life functioning: a 2-year follow-up of early psychosis
Authors: Li Shen , Chan Shi Yu , Higgins Amy , Hall Mei-Hua 
Published: November 2021

AbstractBackgroundDiminished sensory gating (SG) is a robust finding in psychotic disorders, but studies of early psychosis (EP) are rare. It is unknown whether SG deficit leads to poor neurocognitive, social, and/or real-world functioning. This study aimed to explore the longitudinal relationships between SG and these variables.MethodsSeventy-nine EP patients and 88 healthy controls (HCs) were recruited at baseline. Thirty-three and 20 EP patients completed 12-month and 24-month follow-up, respectively. SG was measured using the auditory dual-click (S1 & S2) paradigm and quantified as P50 ratio (S2/S1) and difference (S1-S2). Cognition, real-life functioning, and symptoms were assessed using the MATRICS Consensus Cognitive Battery, Global Functioning: Social (GFS) and Role (GFR), Multnomah Community Ability Scale (MCAS), Awareness of Social Inference Test (TASIT), and the Positive and Negative Syndrome Scale (PANSS). Analysis of variance (ANOVA), chi-square, mixed model, correlation and regression analyses were used for group comparisons and relationships among variables controlling for potential confounding variables.ResultsIn EP patients, P50 ratio (p < 0.05) and difference (p < 0.001) at 24-month showed significant differences compared with that at baseline. At baseline, P50 indices (ratio, S1-S2 difference, S1) were independently associated with GFR in HCs (all p < 0.05); in EP patients, S2 amplitude was independently associated with GFS (p = 0.037). At 12-month and 24-month, P50 indices (ratio, S1, S2) was independently associated with MCAS (all p < 0.05). S1-S2 difference was a trending predictor of future function (GFS or MCAS).ConclusionsSG showed progressive reduction in EP patients. P50 indices were related to real-life functioning.
Mapping the genetic architecture of suicide attempt and suicide death using polygenic risk scores for clinically-related psychiatric disorders and traits
Authors: Otsuka Ikuo , Galfalvy Hanga , Guo Jia , Akiyama Masato , Rujescu Dan , Turecki Gustavo , Hishimoto Akitoyo , Mann J. John 
Published: November 2021

AbstractBackgroundSuicidal behavior is moderately heritable and a consequence of a combination of the diathesis traits for suicidal behavior and suicide-related major psychiatric disorders. Here, we sought to examine shared polygenic effects between various psychiatric disorders/traits and suicidal behavior and to compare the shared polygenic effects of various psychiatric disorders/traits on non-fatal suicide attempt and suicide death.MethodsWe used our genotyped European ancestry sample of 260 non-fatal suicide attempters, 317 suicide decedents and 874 non-psychiatric controls to test whether polygenic risk scores (PRSs) obtained from large GWASs for 22 suicide-related psychiatric disorders/traits were associated with suicidal behavior. Results were compared between non-fatal suicide attempt and suicide death in a sensitivity analysis.ResultsPRSs for major depressive disorder, bipolar disorder, schizophrenia, ADHD, alcohol dependence, sensitivity to environmental stress and adversity, educational attainment, cognitive performance, and IQ were associated with suicidal behavior (Bonferroni-corrected p < 2.5 × 10−4). The polygenic effects of all 22 psychiatric disorders/traits had the same direction (p for binomial tests = 4.8 × 10−7) and were correlated (Spearman's ρ = 0.85) between non-fatal suicide attempters and suicide decedents.ConclusionsWe found that polygenic effects for major psychiatric disorders and diathesis-related traits including stress responsiveness and intellect/cognitive function contributed to suicidal behavior. While we found comparable polygenic architecture between non-fatal suicide attempters and suicide decedents based on correlations with PRSs of suicide-related psychiatric disorders/traits, our analyses are limited by small sample size resulting in low statistical power to detect difference between non-fatal suicide attempt and suicide death.
Interpersonal dysfunction in individuals high in chronic worry: relations with interpersonal problem-solving
Authors: Malivoire Bailee L. , Koerner Naomi 
Published: November 2021

AbstractBackground:Interpersonal dysfunction has been proposed as an important maintenance factor in chronic worry and generalized anxiety disorder (GAD). Perceptions of problems and the problem-solving process as threatening, and unhelpful (e.g. avoidant, impulsive) problem-solving styles are implicated in worry and have also been suggested to be associated with dysfunctional interpersonal styles.Aims:The present study assessed the relationships between interpersonal dysfunction and problem-solving orientation, approach, and effectiveness in a sample of individuals high in chronic worry and investigated the indirect effect of interpersonal dysfunction on GAD symptom severity through negative problem-solving beliefs and approaches.Method:Fifty-nine community participants completed questionnaires and an interpersonal problem-solving task.Results:Greater interpersonal dysfunction was significantly associated with greater negative problem-solving orientation and greater habitual avoidant and impulsive/careless problem-solving styles. Greater interpersonal dysfunction was associated with poorer effectiveness of solutions when the task problem involved conflict with a romantic partner. Negative problem-solving orientation fully mediated the relationship between interpersonal dysfunction and GAD symptoms.Conclusions:These findings support that problem-solving processes are implicated in interpersonal dysfunction and that negative beliefs about problem-solving account for the relationship between interpersonal dysfunction and GAD symptoms. Theoretical implications are discussed.
Using 360-degree videos for virtual reality exposure in CBT for panic disorder with agoraphobia: a feasibility study
Authors: Lundin Johan , Lundström Anders , Gulliksen Jan , Blendulf Joakim , Ejeby Kersti , Nyman Hedda , Björkander Daniel , Hedman-Lagerlöf Erik 
Published: November 2021

AbstractBackground:Cognitive behavioural therapy (CBT) is an effective treatment for panic disorder with agoraphobia (PDA). However, implementation of some of the procedures involved, particularly in vivo exposure, can be time consuming and taxing for routine health care services. CBT with exposure taking place in virtual reality (VR-CBT) is a more time-efficient option and has shown promising results in the treatment of PDA. However, VR-CBT requires expensive equipment and appropriate virtual environments, which historically has been costly and cumbersome to produce. Thus, access to VR-CBT has been sparse in regular care environments.Aims:The aim of this study was to investigate whether VR-CBT using filmed virtual environments produced with a low-cost 360-degree film camera can be a feasible and acceptable treatment for PDA when implemented in a primary care context.Method:This was an open feasibility trial with a within-group design, with assessments conducted at pre-test, post-test, and 6-month follow-up. Participants (n = 12) received a 10–12 week treatment programme of VR-CBT and PDA-related symptoms were assessed by the primary outcome measure The Mobility Inventory for Agoraphobia (MIA) and the Panic-Disorder Severity Scale-Self Rated (PDSS-SR).Results:The results showed that treatment satisfaction was high and participants were significantly improved on PDA-related measures at post-treatment and at 6-month follow-up with large effect sizes (Cohen’s d range = 1.46–2.82). All 12 participants completed the treatment.Conclusions:These findings suggest that VR-CBT with 360-degree video virtual environments delivered to primary care patients with PDA is feasible, acceptable, and potentially efficacious.
Stufen der Veränderung
Authors: Hieke André 
Published: November 2021

Was ist zu diesem Thema bereits bekannt? Der Einsatz des in England entwickelten Assessmentinstruments ist derzeit begrenzt auf bestimmte englischsprachige Länder, wo es von vielen Einrichtungen genutzt wird, um Menschen mit einer Vielzahl von kurz- und langfristigen psychischen Problemen zu unterstützen. Im deutschsprachigen Raum, insbesondere in Deutschland, werden die Recovery-Stars™ bisher nicht verwendet. Wie wird eine neue Perspektive eingebracht? Mithilfe des MHRS™ und seiner zehn Bereiche (siehe Abbildung 1) lässt sich deutlich erkennen, auf welcher Entwicklungsstufe ein Betroffener sich gerade befindet. Der MHRS™ hilft den Betroffenen, das Ganze zu sehen und macht es für die professionell Tätigen leichter, die jeweiligen Veränderungen oder Stagnationen im Behandlungsprozess sichtbar zu machen. Aus Sicht des Verfassers ist der MHRS™ eine Bewertungshilfe und ein Messinstrument für Behandlungserfolge in der recovery-orientierten psychiatrischen Versorgung. Was sind die Auswirkungen auf die Praxis? Verschiedene Konzepte wie die Bezugspersonenpflege und das Recovery-Konzept wirbeln das klassische Rollenverständnis von professionell Tätigen in der Psychiatrie (Pflegenden, Psycholog_innen, Ärzt_innen) durcheinander. Psychisch erkrankte Menschen und professionell Tätige rücken bei beiden Konzepten näher zusammen und werden gleichberechtigte Partner im Behandlungs- und Unterstützungsprozess. Mithilfe des MHRS™ steht der oder die Betroffene im Mittelpunkt der Behandlung, denn nur er oder sie entscheidet, wohin der Weg geht. Die professionell Tätigen unterstützen ihn oder sie im Rahmen ihrer Möglichkeiten.
HAPI: An API Standard for Accessing Heliophysics Time Series Data
Authors: Weigel Robert S. , Vandegriff Jon , Faden Jeremy , King Todd , Roberts D Aaron , Harris Bernard , Candey Robert , Lal Nand , Boardsen Scott , Lindholm Chris , Lindholm Doug , Baltzer Thomas , Brown Lawrence E. , Grimes Eric W. , Cecconi Baptiste , Génot Vincent , Renard Benjamin , Masson Arnaud , Martinez Beatriz 
Published: November 2021

AbstractHeliophysics data analysis often involves combining diverse science measurements, many of them captured as time series. Although there are now only a few commonly used data file formats, the diversity in mechanisms for automated access to and aggregation of such data holdings can make analysis that requires intercomparison of data from multiple data providers difficult. The Heliophysics Application Programmer's Interface (HAPI) is a recently developed standard for accessing distributed time series data to increase interoperability. The HAPI specification is based on the common elements of existing data services, and it standardizes the two main parts of a data service: the request interface and the response data structures. The interface is based on the REpresentational State Transfer (REST) or RESTful architecture style, and the HAPI specification defines five required REST endpoints. Data are returned via a streaming format that hides file boundaries; the metadata is detailed enough for the content to be scientifically useful, e.g., plotted with appropriate axes layout, units, and labels. Multiple mature HAPI‐related open‐source projects offer server‐side implementation tools and client‐side libraries for reading HAPI data in multiple languages (IDL, Java, MATLAB, and Python). Multiple data providers in the US and Europe have added HAPI access alongside their existing interfaces. Based on this experience, data can be served via HAPI with little or no information loss compared to similar existing web interfaces. Finally, HAPI has been recommended as a COSPAR standard for time series data delivery.
Structural and Thermal Evolution of an Infant Subduction Shear Zone: Insights From Sub‐Ophiolite Metamorphic Rocks Recovered From Oman Drilling Project Site BT‐1B
Authors: Kotowski Alissa J. , Cloos Mark , Stockli Daniel F. , Bos Orent Eytan 
Published: November 2021

AbstractSubduction interface thermal structure changes drastically within the first few million years of underthrusting (i.e., subduction infancy). Metamorphic soles beneath ophiolites record snapshots of dynamic conditions and mechanical coupling during subduction infancy. Beneath the Samail Ophiolite (Oman), the sole comprises structurally higher high‐temperature (HT) and lower low‐temperature (LT) units. This inverted metamorphic gradient has been attributed to evolving metamorphic Pressure‐Temperature (P‐T) conditions during infancy; however, peak P‐T and timing of LT sole subduction are poorly constrained. Oman Drilling Project core BT‐1B sampled the base of the ophiolite in a location lacking the HT sole. Metasedimentary and meta‐mafic samples collected from 104 m of core reveal that the LT sole subducted to similar peak P as HT rocks preserved elsewhere in Oman, but experienced ∼300°C lower peak T. Prograde fabrics record Si‐in‐phengite and amphibole chemistries consistent with peak P‐T of ∼7–10 kbar and ∼450–550°C in the epidote‐amphibolite facies. Retrograde fabrics record a transition from near‐pervasive ductile to localized brittle strain under greenschist facies conditions. Titanite U‐Pb ages (n = 2) constrain timing of peak LT sole subduction to ∼91 Ma (post‐dating initial HT sole subduction by ∼12–13 Myr) and dynamic retrogression through ∼90 Ma. Combined with existing geo/thermo‐chronology, our results support a model of protracted subduction and accretion while the infant subduction zone experienced multi‐phase, slow‐fast‐slow cooling. Temporal overlap of HT sole cooling (rehydration?) and ophiolite formation suggests that cooling may lead to interface weakening, facilitating upper‐plate extension and spreading. The LT sole formed in a rapidly‐refrigerating forearc after ophiolite formation and may reflect the transition to self‐sustaining subduction.
Intra‐Annual Variation of Eddy Diffusion (kzz) in the MLT, From SABER and SCIAMACHY Atomic Oxygen Climatologies
Authors: Swenson G. R. , Vargas F. , Jones M. , Zhu Y. , Kaufmann M. , Yee J. H. , Mlynczak M. 
Published: November 2021

AbstractAtomic oxygen (O) in the mesosphere and lower thermosphere (MLT) results from a balance between production via photo‐dissociation in the lower thermosphere and chemical loss by recombination in the upper mesosphere. The transport of O downward from the lower thermosphere into the mesosphere is preferentially driven by the eddy diffusion process that results from dissipating gravity waves and instabilities. The motivation here is to probe the intra‐annual variability of the eddy diffusion coefficient (kzz) and eddy velocity in the MLT based on the climatology of the region, initially accomplished by Garcia and Solomon (1985, https://doi.org/10.1029/JD090iD02p03850). In the current study, the intra‐annual cycle was divided into 26 two‐week periods for each of three zones: the northern hemisphere (NH), southern hemisphere (SH), and equatorial (EQ). Both 16 years of SABER (2002–2018) and 10 years of SCIAMACHY (2002–2012) O density measurements, along with NRLMSIS® 2.0 were used for calculation of atomic oxygen eddy diffusion velocities and fluxes. Our prominent findings include a dominant annual oscillation below 87 km in the NH and SH zones, with a factor of 3–4 variation between winter and summer at 83 km, and a dominant semiannual oscillation at all altitudes in the EQ zone. The measured global average kzz at 96 km lacks the intra‐annual variability of upper atmosphere density data deduced by Qian et al. (2009, https://doi.org/10.1029/2008JA013643). The very large seasonal (and hemispherical) variations in kzz and O densities are important to separate and isolate in satellite analysis and to incorporate in MLT models.
Modeling the Sulfate Aerosol Evolution After Recent Moderate Volcanic Activity, 2008–2012
Authors: Brodowsky Christina , Sukhodolov Timofei , Feinberg Aryeh , Höpfner Michael , Peter Thomas , Stenke Andrea , Rozanov Eugene 
Published: November 2021

AbstractVolcanic activity is a major natural climate forcing and an accurate representation of volcanic aerosols in global climate models is essential. This is a complex task involving many uncertainties in the model design and setup and observations. We analyze the performance of the aerosol‐chemistry‐climate model SOCOL‐AERv2 for three medium‐sized volcanic eruptions. We focus on the impact of differences in volcanic plume height and SO2 estimates on the stratospheric aerosol burden. The influence of internal model variability and dynamics are addressed through an ensemble of free‐running and nudged simulations at different vertical resolutions. Comparing the modeled evolution of the stratospheric aerosol loading to satellite measurements reveals a good model performance. However, a conclusive validation is complicated by uncertainties in observations and emission estimates. The large spread in emitted sulfur amount and its vertical distribution consequently lead to differences in simulated aerosol burdens. Varying tropopause heights among free‐running simulations add to these differences, modulating the amount of sulfur injected into the stratosphere. In nudged mode, volcanic aerosol burden peaks are well reproduced, however changes in convection and clouds affect SO2 oxidation paths and cross‐tropopause transport, leading to increased background burdens compared to observations. This effect can be reduced by leaving temperatures unconstrained. A higher vertical resolution of 90 levels increases the stratospheric residence time of sulfate aerosol by reducing the diffusion out of the tropical reservoir. We conclude that the model set‐up (vertical resolution and free‐running vs. nudged) as well as forcing parameters (volcanic emission strength and plume height) contribute equally to the model uncertainties.
Impacts of Bias‐Corrected ERA5 Initial Snow Depth on Dynamical Downscaling Simulations for the Tibetan Plateau
Authors: Lin Qian , Chen Jie , Chen Deliang , Wang Xun , Li Wei , Scherer Dieter 
Published: November 2021

AbstractThe Tibetan Plateau (TP) is often called the “Water Tower of Asia,” which contains the largest amount of snow and glaciers outside the polar regions. As an important and variable feature of the land surface, snow coverage on the TP has great impacts on regional climate. However, the commonly used ERA5 reanalysis in dynamical downscaling largely overestimates the snow depth for the TP. To improve the representation of snow cover in ERA5, a new ERA5‐driven downscaling data set (High Asia Refined analysis version 2, HAR v2) was generated by the Weather Research and Forecasting (WRF) model with the bias‐corrected snow depth. This study aims to identify and better understand the impact of bias‐corrected initial snow conditions on simulated regional climate, by comparing the HAR v2 with a 5‐year ERA5 forced WRF simulation without bias correction of initial snow depth (referred to as WRF_ERA5). The results show that the bias correction significantly improves the simulation of 2 m air temperature (T2), with regional mean cold bias reduced by 0.2°C–2.4°C, but no significant improvement in precipitation simulation is found. Further comparative analysis reveals that higher snow depth in WRF_ERA5 leads to T2, mean daily precipitation, summer extreme precipitation, and contributions of convective precipitation to summer mean daily precipitation decrease by 0°C–4°C, 0%–60%, 0%–40%, and 0%–10%, respectively, in most areas of the TP. In addition, the bias‐corrected initial snow depth also has impacts on simulated diurnal cycles of precipitation and T2 and leads to peak hours one hour earlier. Overall, this study confirms the importance of snow cover for the climate in the TP.
The Onset of a Globally Ice‐Covered State for a Land Planet
Authors: Kodama T. , Genda H. , Leconte J. , Abe‐Ouchi A. 
Published: November 2021

AbstractThe climates of terrestrial planets with a small amount of water on their surface, called land planets, are significantly different from the climates of planets having a large amount of surface water. Land planets have a higher runaway greenhouse threshold than aqua planets, which extends the inner edge of the habitable zone inward. Land planets also have the advantage of avoiding global freezing due to drier tropics, leading to a lower planetary albedo. In this study, we systematically investigate the complete freezing limit for various surface water distributions using a three‐dimensional dynamic atmospheric model. As in a previous study, we found that a land planet climate has dry tropics that result in less snow and fewer clouds. The complete freezing limit decreases from that for aqua planets (92% S0, where S0 is Earth's present insolation) to that for land planets (77% S0) with an increasing dry area. Values for the complete freezing limit for zonally uniform surface water distributions are consistently lower than those for meridionally uniform surface water distribution. This is because the surface water distribution in the tropics in the meridionally uniform cases causes ice‐albedo feedback until a planet lapses into the complete freezing state. For a surface water distribution using the topographies of the terrestrial planets, the complete freezing limit has values near those for the meridionally uniform cases. Our results indicate that the water distribution is important for the onset of a global ice‐covered state for Earth‐like exoplanets.
Fidelity of the Coral Sr/Ca Paleothermometer Following Heat Stress in the Northern Galápagos
Authors: Cheung Anson H. , Cole Julia E. , Thompson Diane M. , Vetter Lael , Jimenez Gloria , Tudhope Alexander W. 
Published: November 2021

AbstractCoral Sr/Ca records have been widely used to reconstruct and understand past sea surface temperature (SST) variability in the tropical Pacific. However, in the eastern equatorial Pacific, coral growth conditions are marginal, and strong El Niño events have led to high mortality, limiting opportunities for coral Sr/Ca‐based SST reconstructions. In this study, we present two ∼25‐year Sr/Ca and Mg/Ca records measured on modern Porites lobata from Wolf and Darwin Islands in the northern Galápagos. In these records, we confirm the well‐established relationship between Sr/Ca and SST and investigate the impact of heat stress on this relationship. We demonstrate a weakened relationship between Sr/Ca and SST after a major (Degree Heating Months 9°C‐months) heat stress event during the 1997–1998 El Niño, with a larger response in the Wolf core. However, removing data that covers the 1997–1998 El Niño from calibration does not improve reconstruction statistics. Nevertheless, we find that excluding data after the 1997–1998 El Niño event from the calibration reduces the SST reconstruction error slightly. These results confirm that coral Sr/Ca is a reliable SST proxy in this region, although it can respond adversely to unusual heat stress. We suggest that noise in Sr/Ca‐SST calibrations may be reduced by removing data immediately following large heat extremes.