bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clopidogrel vs. prasugrel vs. ticagrelor in patients with acute myocardial infarction complicated by cardiogenic shock: a pooled IABP-SHOCK II and CULPRIT-SHOCK trial sub-analysis
Authors: Orban Martin , Kleeberger Jan , Ouarrak Taoufik , Freund Anne , Feistritzer Hans-Josef , Fuernau Georg , Geisler Tobias , Huber Kurt , Dudek Dariusz , Noc Marko , Montalescot Gilles , Neumer Alexander , Haller Paul , Clemmensen Peter , Zeymer Uwe , Desch Steffen , Massberg Steffen , Schneider Steffen , Thiele Holger , Hausleiter Jörg 
Published: May 2021

Abstract
Aims
The aim of this pooled sub-analysis of the Intraaortic Balloon Pump in Cardiogenic Shock II (IABP-SHOCK II) and Culprit Lesion Only PCI versus Multivessel PCI in Cardiogenic Shock (CULPRIT-SHOCK) trial was to compare the clinical outcome of patients with acute myocardial infarction complicated by cardiogenic shock treated either with clopidogrel or the newer, more potent ADP-receptor antagonists prasugrel or ticagrelor.

Methods and results
For the current analysis the primary endpoint was 1-year mortality and the secondary safety endpoint was moderate or severe bleedings until hospital discharge with respect to three different ADP-receptor antagonists. 856 patients were eligible for analysis. Of these, 507 patients (59.2%) received clopidogrel, 178 patients (20.8%) prasugrel and 171 patients (20.0%) ticagrelor as acute antiplatelet therapy. The adjusted rate of mortality after 1-year did not differ significantly between prasugrel and clopidogrel (hazard ratio [HR]: 0.81, 95% confidence interval [CI] 0.60–1.09, padj = 0.17) or between ticagrelor and clopidogrel treated patients (HR: 0.86, 95% CI 0.65–1.15, padj = 0.31). In-hospital bleeding events were significantly less frequent in patients treated with ticagrelor vs. clopidogrel (HR: 0.37, 95% CI 0.20 -0.69, padj = 0.002) and not significantly different in patients treated with prasugrel vs. clopidogrel (HR: 0.73, 95% CI 0.43 -1.24, padj = 0.24).

Conclusion
This pooled sub-analysis is the largest analysis on safety and efficacy of three oral ADP-receptor antagonists and shows that acute therapy with either clopidogrel, prasugrel or ticagrelor is no independent predictor of 1-year mortality. Treatment with ticagrelor seems independently associated with less in-hospital moderate and severe bleeding events compared to clopidogrel. This finding might be due to selection bias and should be interpreted with caution.

Graphic abstract
Less than half of the European dietary recommendations for fish consumption are satisfied by national seafood supplies
Authors: Lofstedt Anneli , de Roos Baukje , Fernandes Paul G. 
Published: May 2021

Abstract
Purpose
To review the seafood dietary recommendations of European countries and compare them to national seafood supplies.

Methods
Current seafood dietary recommendations were collated from national health authorities across Europe. Food balance sheets were downloaded from the FAO, and appropriate conversion factors were applied to each seafood commodity. Average net per capita seafood supplies from 2007 to 2017 were derived from data on imports and production for food from both capture fisheries and aquaculture, accounting for exports.

Results
Both national dietary recommendations and seafood supplies varied considerably throughout Europe. At a national level, on a per capita basis, only 13 out of the 31 of European dietary recommendations for fish consumption were satisfied by national seafood supplies. Most of the countries with coastal access, as well as those with traditional fish-eating cultures, such as France and countries in Northern Europe, had adequate seafood supplies to meet their recommendations. The landlocked countries of Central and Eastern Europe did not have enough seafood supplies to satisfy their recommendations.

Conclusions
Our findings emphasise the need to not only consider consumer health outcomes when developing and advocating dietary recommendations, but also the sustainability of food production systems. As many foods are not necessarily locally sourced but traded as part of global production and distribution systems, it is important to consider greater consistency between national dietary recommendations to facilitate more sustainable marine food systems.
A hybrid $$ H ^1\times H (\mathrm {curl})$$ finite element formulation for a relaxed micromorphic continuum model of antiplane shear
Authors: Sky Adam , Neunteufel Michael , Münch Ingo , Schöberl Joachim , Neff Patrizio 
Published: May 2021

AbstractOne approach for the simulation of metamaterials is to extend an associated continuum theory concerning its kinematic equations, and the relaxed micromorphic continuum represents such a model. It incorporates the Curl of the nonsymmetric microdistortion in the free energy function. This suggests the existence of solutions not belonging to$$ H ^1$$H1, such that standard nodal$$ H ^1$$H1-finite elements yield unsatisfactory convergence rates and might be incapable of finding the exact solution. Our approach is to use base functions stemming from both Hilbert spaces$$ H ^1$$H1and$$ H (\mathrm {curl})$$H(curl), demonstrating the central role of such combinations for this class of problems. For simplicity, a reduced two-dimensional relaxed micromorphic continuum describing antiplane shear is introduced, preserving the main computational traits of the three-dimensional version. This model is then used for the formulation and a multi step investigation of a viable finite element solution, encompassing examinations of existence and uniqueness of both standard and mixed formulations and their respective convergence rates.
Schätzung der Verdunstung mithilfe von Machine- und Deep Learning-Methoden
Authors: Brenner Claire , Frame Jonathan , Nearing Grey , Schulz Karsten 
Published: May 2021

ZusammenfassungDie Verdunstung ist ein entscheidender Prozess im globalen Wasser‑, Energie- sowie Kohlenstoffkreislauf. Daten zur räumlich-zeitlichen Dynamik der Verdunstung sind daher von großer Bedeutung für Klimamodellierungen, zur Abschätzung der Auswirkungen der Klimakrise sowie nicht zuletzt für die Landwirtschaft.In dieser Arbeit wenden wir zwei Machine- und Deep Learning-Methoden für die Vorhersage der Verdunstung mit täglicher und halbstündlicher Auflösung für Standorte des FLUXNET-Datensatzes an. Das Long Short-Term Memory Netzwerk ist ein rekurrentes neuronales Netzwerk, welchen explizit Speichereffekte berücksichtigt und Zeitreihen der Eingangsgrößen analysiert (entsprechend physikalisch-basierten Wasserbilanzmodellen). Dem gegenüber gestellt werden Modellierungen mit XGBoost, einer Entscheidungsbaum-Methode, die in diesem Fall nur Informationen für den zu bestimmenden Zeitschritt erhält (entsprechend physikalisch-basierten Energiebilanzmodellen). Durch diesen Vergleich der beiden Modellansätze soll untersucht werden, inwieweit sich durch die Berücksichtigung von Speichereffekten Vorteile für die Modellierung ergeben.Die Analysen zeigen, dass beide Modellansätze gute Ergebnisse erzielen und im Vergleich zu einem ausgewerteten Referenzdatensatz eine höhere Modellgüte aufweisen. Vergleicht man beide Modelle, weist das LSTM im Mittel über alle 153 untersuchten Standorte eine bessere Übereinstimmung mit den Beobachtungen auf. Allerdings zeigt sich eine Abhängigkeit der Güte der Verdunstungsvorhersage von der Vegetationsklasse des Standorts; vor allem wärmere, trockene Standorte mit kurzer Vegetation werden durch das LSTM besser repräsentiert, wohingegen beispielsweise in Feuchtgebieten XGBoost eine bessere Übereinstimmung mit den Beobachtung liefert. Die Relevanz von Speichereffekten scheint daher zwischen Ökosystemen und Standorten zu variieren.Die präsentierten Ergebnisse unterstreichen das Potenzial von Methoden der künstlichen Intelligenz für die Beschreibung der Verdunstung.
Glucose variability and periodontal disease in type 1 diabetes: a cross-sectional study—The “PAROdontopatia e DIAbete” (PARODIA) project
Authors: Dicembrini Ilaria , Barbato Luigi , Serni Lapo , Caliri Mariasmeralda , Pala Laura , Cairo Francesco , Mannucci Edoardo 
Published: May 2021

AbstractAimsPeriodontal disease (PD) is a chronic inflammation of periodontal tissue associated with infection from specific anaerobic pathogens contained in dental plaque. Both type 1 and type 2 diabetes are associated with an increased prevalence of PDs. A two-way relationship between diabetes and periodontitis has been proposed, with diabetes increasing the risk for periodontitis, and periodontal inflammation negatively affecting glycaemic control. To date, the relationship between PD and glucose variability in type 1 diabetes has not been evaluated. To investigate the prevalence of PD in patients with type 1 diabetes and its association with glycemic control and glucose variability.MethodsIn this cross-sectional study, all enrolled patients were scheduled to attend both a diabetologic and a periodontal visit. HbA1c, glucose coefficient of variation (CV), loss of clinical attachment (CAL), and periodontal probing depth (PPD) were collected.Results136 patients were included in the analysis. The prevalence of PD was 63%. A significant correlation was found between mean CAL and glucose CV (r = 0.31,p = 0.002), but not with HbA1c. Mean PPD was also associated with glucose CV (r = 0.27 and 0.044), but not with HbA1c. In a multiple linear regression model, with mean CAL as dependent variable, age, glucose CV, and smoking habit resulted significantly associated (r = 0.23,p = 0.013;r = 0.33,p = 0.001;r = 0.34,p < 0.001, respectively). Assuming mean PPD as dependent variable, multiple linear regression analysis showed a significant association with glucose CV and smoking habits only.ConclusionsPD is associated with glucose variability in patients with type 1 diabetes also after adjusting for the main confounders.
Ultrastructural characterization of peripheral denervation in a mouse model of Type III spinal muscular atrophy
Authors: Fulceri Federica , Biagioni Francesca , Limanaqi Fiona , Busceti Carla L. , Ryskalin Larisa , Lenzi Paola , Fornai Francesco 
Published: May 2021

AbstractSpinal muscular atrophy (SMA) is a heritable, autosomal recessive neuromuscular disorder characterized by a loss of the survival of motor neurons (SMN) protein, which leads to degeneration of lower motor neurons, and muscle atrophy. Despite SMA being nosographically classified as a motor neuron disease, recent advances indicate that peripheral alterations at the level of the neuromuscular junction (NMJ), involving the muscle, and axons of the sensory-motor system, occur early, and may even precede motor neuron loss. In the present study, we used a mouse model of slow progressive (type III) SMA, whereby the absence of the mouse SMN protein is compensated by the expression of two human genes (heterozygousSMN1A2G, andSMN2). This leads to late disease onset and prolonged survival, which allows for dissecting slow degenerative steps operating early in SMA pathogenesis. In this purely morphological study carried out at transmission electron microscopy, we extend the examination of motor neurons and proximal axons towards peripheral components, including distal axons, muscle fibers, and also muscle spindles. We document remarkable ultrastructural alterations being consistent with early peripheral denervation in SMA, which may shift the ultimate anatomical target in neuromuscular disease from the spinal cord towards the muscle. This concerns mostly mitochondrial alterations within distal axons and muscle, which are quantified here through ultrastructural morphometry. The present study is expected to provide a deeper knowledge of early pathogenic mechanisms in SMA.
Altered gut microbiota correlates with cognitive impairment in Chinese children with Down’s syndrome
Authors: Ren Shimeng , Wang Xinjuan , Qin Jiong , Mu Qing , Ye Shuai , Zhang Yang , Yu Weidong , Guo Jingzhu 
Published: May 2021

AbstractDown's syndrome (DS), a common chromosomal disease caused by chromosome 21 trisomy, is the main cause of cognitive impairment in children worldwide. Emerging evidence suggests that the microbiota–gut–brain axis plays a potential role in cognitive impairment. However, data regarding gut microbiota alterations in DS patients remain scarce, especially data from children with DS. This case–control study was conducted to explore the gut microbiota composition in Chinese DS children. Additionally, the potential association between gut microbiota and cognitive function in DS was evaluated. Microbiota communities in the feces of 15 DS subjects and 15 matched controls were investigated using high-throughput Illumina Miseq sequencing targeting the V3–V4 region of 16S rRNA gene. The relationships between gut microbiota composition and DS cognitive function scores were analyzed. The structure and richness of the gut microbiota differed between DS patients and healthy controls. The abundance of Acidaminococcaceae was decreased in DS patients. Moreover, the Kyoto Encyclopedia of Genes and Genomes analysis showed increased modules related to peptidases and pyrimidine metabolism. Overall, we confirmed that gut microbiota alterations occurred in Chinese patients with DS. Additionally, the fecal microbiota was closely related to DS cognitive impairment. Larger cohorts are needed to confirm these findings and to clarify the mechanisms involved. Elucidating these novel findings in the field of microbiota-gut-brain axis will provide a promising strategy for future studies of DS cognitive impairment.
Entry regulations and optimal prize allocation in parallel contests
Authors: Grossmann Martin 
Published: May 2021

AbstractIn parallel contests, the contest organizer controls the entry of heterogeneous contestants by regulating access to the contests and determining the prize allocation across contests. The organizer can prevent a contestant from entering more than one contest. I show that the organizer allows entry to multiple contests and uniquely sets identical prizes across contests to maximize aggregate effort in all contests. Independent of the entry regulation, I find no sorting effects. Thus, a contest with a relatively high prize does not necessarily attract contestants with higher abilities. Furthermore, I discover interesting spillover effects of prizes between contests in the case of restricted entry regulations. For instance, the individual (aggregate) effort increases (decreases) in a contest if the prize in another contest increases. The endogeneity of contestants’ participation drives many of these results.
Duration of the final phase of mining area deformation process in the conditions of Upper Silesia (Poland)
Authors: Strzałkowski Piotr 
Published: May 2021

AbstractThe ability to estimate the duration of mining impact on the surface is important for both active and decommissioned mines. It allows to plan rational land development and to assess the time of exploitation impact on buildings. The data concerns cases of exploitation with roof caving in 20 hard coal mines in Upper Silesia and cases of exploitation with hydraulic stowing in 4 mines. Based on the analysis of geological and mining documentation, the duration of the final stage of the subsidence process was established — from the end of mining operations to the final stage of the subsidence. It was assumed that the subsidence reached its final state when the increments between two consecutive measurements did not exceed 10 mm. Further analyses were carried out using the regression method using the Statistica program, looking for the relationship between the duration of the final phase of the subsidence process and the quantities characterizing the operating conditions. The obtained results indicate a significant impact of the depth of exploitation and the value of the parameter characterizing the rock mass strength properties on the duration of the final phase of the deformation process. As a result of statistical analyses, appropriate empirical formulas were proposed. In the case of performing exploitation with caving and when the variation in the value of tgβ parameter characterizing the rock mass is small, which currently occurs in the considered basin, one can use the proposed formula, linking the duration of the process with the depth of mining exploitation.
Konjunktur der Bundesländer: große Unterschiede, aber wenig aussagefähige Daten
Authors: Döhrn Roland 
Published: May 2021

ZusammenfassungIm März 2021 legte der Arbeitskreis der Volkswirtschaftlichen Gesamtrechnungen der Länder die ersten Berechnungen zur Wirtschaftsleistung der Länder für 2020 vor. Es zeigen sich auch in der Corona-Krise deutliche Unterschiede zwischen den Ländern. Die Gründe hierfür sind vielfältig. Jedoch müssen diese vorläufigen Zahlen mit Vorsicht interpretiert werden, da die folgenden Revisionen die Positionen der Länder verändern können, wie der vorliegende Beitrag verdeutlicht.
Mehr Kooperation von Start-ups und Mittelstand als Chance für Digitalisierung und Innovationen
Authors: Röhl Klaus-Heiner , Engels Barbara 
Published: May 2021

ZusammenfassungDie Corona-Krise hat die Defizite Deutschlands in der Digitalisierung von Wirtschaft und Gesellschaft schlagartig offengelegt. Die Zusammenarbeit von etabliertem Mittelstand und innovativen Start-ups — oft mit digitalen Geschäftsmodellen — bietet dabei große Chancen für die Beteiligten und die Wirtschaft insgesamt. Auch könnte das demografiebedingt nachlassende Wachstumspotenzial der deutschen Wirtschaft steigen.
Joint physical custody, parent–child relationships, and children’s psychosomatic problems
Authors: Augustijn Lara 
Published: May 2021

Abstract
Aim
The prevalence of psychosomatic complaints among children and adolescents appears to be increasing. At the same time, the numbers of joint physical custody families are rising across Western countries. This study aimed to investigate the relationship between post-separation care arrangements (joint physical custody vs. sole physical custody) and children’s risks of psychosomatic problems, while considering the potential mediating role of parent–child relationships.

Subject and methods
Based on data from the Family Models in Germany (FAMOD) study, stepwise linear regression models and seemingly unrelated regression models were estimated for a sample of 473 children aged seven to 14 living in either sole physical custody or joint physical custody families.

Results
Children in joint physical custody families reported significantly fewer psychosomatic problems than children in sole physical custody families. Furthermore, living in a joint physical custody arrangement was associated with better parent–child relationships, although only the mother–child relationship was significantly related to children’s psychosomatic complaints, and partially mediated the association between physical custody arrangements and children’s psychosomatic complaints. No corresponding association could be found with respect to the father–child relationship.

Conclusion
The risk of psychosomatic problems was distributed unequally among post-separation families, as children living in joint physical custody arrangements suffered from fewer psychosomatic problems than children living in sole physical custody arrangements. Because part of this association was explained by the quality of the mother–child relationship, children’s relationships with other family members appear to be important factors to consider when seeking to promote children’s health in post-separation care arrangements.
Seismic hazard for the Trans Adriatic Pipeline (TAP). Part 1: probabilistic seismic hazard analysis along the pipeline
Authors: Slejko D. , Rebez A. , Santulin M. , Garcia-Pelaez J. , Sandron D. , Tamaro A. , Civile D. , Volpi V. , Caputo R. , Ceramicola S. , Chatzipetros A. , Daja S. , Fabris P. , Geletti R. , Karvelis P. , Moratto L. , Papazachos C. , Pavlides S. , Rapti D. , Rossi G. , Saraò A. , Sboras S. , Vuan A. , Zecchin M. , Zgur F. , Zuliani D. 
Published: May 2021

AbstractThe design of critical facilities needs a targeted computation of the expected ground motion levels. The Trans Adriatic Pipeline (TAP) is the pipeline that transports natural gas from the Greek-Turkish border, through Greece and Albania, to Italy. We present here the probabilistic seismic hazard analysis (PSHA) that we performed for this facility, and the deaggregation of the results, aiming to identify the dominant seismic sources for a selected site along the Albanian coast, where one of the two main compressor stations is located. PSHA is based on an articulated logic tree of twenty branches, consisting of two models for source, seismicity, estimation of the maximum magnitude, and ground motion. The area with the highest hazard occurs along the Adriatic coast of Albania (PGA between 0.8 and 0.9 g on rock for a return period of 2475 years), while strong ground motions are also expected to the north of Thessaloniki, Kavala, in the southern Alexandroupolis area, as well as at the border between Greece and Turkey. The earthquakes contributing most to the hazard of the test site at high and low frequencies (1 and 5 Hz) and the corresponding design events for the TAP infrastructure have been identified as local quakes withMW6.6 and 6.0, respectively.
Effect of Different Synthesis Approaches on Structural and Thermal Properties of Lanthanide(III) Metal–Organic Frameworks Based on the 1H-Pyrazole-3,5-Dicarboxylate Linker
Authors: Vlasyuk Dmytro , Łyszczek Renata 
Published: May 2021

AbstractThe impact of different synthetic procedures such as: hydrothermal, mechanochemical and precipitation on the structure and thermal properties of coordination polymers of 1H-pyrazole-3,5-dicarboxylic acid (H3pdca) with selected lanthanide ions was determined. The prepared complexes of the general formula: Ln2(Hpdca)3⋅nH2O, where Ln = Eu(III), Nd(III), Tb(III) and Er(III); n = 6 or 7 were fully investigated by: elemental analysis, Energy-Dispersive X-Ray (ED-XRF) and infrared (ATR-FTIR) spectroscopy, powder as well as single-crystal X-ray diffraction methods and thermal analysis (TG-DSC and TG-FTIR) in various atmospheres. It was proved that all used strategies offer high yields of reactions along with crystallinity of the obtained products. The X-ray diffraction methods allowed to conclude that the complexes with the same metal ions exhibit the same crystal structure despite different synthesis routes. On the other hand, the coordination polymers of Eu(III), Tb(III) and Er(III) prepared under different conditions are isomorphous. Only neodymium(III) compounds have a different crystal structure. Thermal stability of the produced complexes was correlated with the synthesis conditions, in particular with the way of energy supply. It was found that the highest thermal stability was exhibited by the complexes prepared under the hydrothermal conditions. Additionally, based on the volatile products of metal complexes decomposition, the mechanism of their pyrolysis was proposed in relation to their structures.