bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect Size of Rituximab on Pulmonary Function in the Treatment of Connective-Tissue Disease-Related Interstitial Lung Disease: A Systematic Review and Meta-Analysis
Authors: Zhao Yuanchen , Gao Yang , Petnak Tananchai , Cheungpasitporn Wisit , Thongprayoon Charat , Zhang Xing , Moua Teng 
Published: September 2021

Abstract
BACKGROUND: Rituximab (RTX) has been previously reported as directed treatment in patients with connective-tissue disease-related interstitial lung diseases (CTD-ILD). A systematic assessment of treatment effect size on pulmonary function outcomes and related adverse effects in patients with CTD-ILD has not been previously reported.METHODS: We performed a systematic review and meta-analysis of published reports from PubMed, Embase, and Cochrane Libraries. Randomized and non-randomized controlled trials, case-control, cohort, and case series (with five or more cases) containing individual pulmonary function data and adverse effects were included. Study endpoints were pre and post treatment change in percent predicted forced vital capacity (FVC %) and diffusion capacity for carbon monoxide (DLCO%), along with reported drug-related adverse events. RESULTS: Twenty studies totaling 411 patients were identified with 14 included in the meta-analysis of pulmonary function and six in the descriptive review. Random effects meta-analysis of pre and post-treatment pulmonary function findings demonstrated increases in FVC% (n =296) (mean difference (MD) 4.57%, [95% CI 2.63-6.51]) and DLCO% (n = 246) (MD 5.0% [95% CI 2.71-7.29]) after RTX treatment. RTX treatment-related adverse effects were reported in 13.6% of the pooled cohort. CONCLUSIONS: A systematic assessment of post-treatment effect size suggests a potential role for RTX in stabilizing or improving lung function in patients with CTD-ILD, with a modest but not insignificant adverse effect profile.
MEG cortical microstates: spatiotemporal characteristics, dynamic functional connectivity and stimulus-evoked responses
Authors: Tait Luke , Zhang Jiaxiang 
Published: September 2021

Abstract
EEG microstate analysis is an approach to study brain states and their fast transitions in healthy cognition and disease. A key limitation of conventional microstate analysis is that it must be performed at the sensor level, and therefore gives limited anatomical insight. Here, we generalise the microstate methodology to be applicable to source-reconstructed electrophysiological data. Using simulations of a neural-mass network model, we first established the validity and robustness of the proposed method. Using MEG resting-state data, we uncovered ten microstates with distinct spatial distributions of cortical activation. Multivariate pattern analysis demonstrated that source-level microstates were associated with distinct functional connectivity patterns. We further demonstrated that the occurrence probability of MEG microstates were altered by auditory stimuli, exhibiting a hyperactivity of the microstate including the auditory cortex. Our results support the use of source-level microstates as a method for investigating brain dynamic activity and connectivity at the millisecond scale.
Feasibility Trial of an Integrated Treatment "Activate for Life" for Physical and Mental Well-being in Older Adults
Authors: Hernandez-Tejada Melba A , Nagel Alexis , Madisetti Mohan , Balasubramanian Sundar , Kelechi Teresa 
Published: September 2021

Abstract
This paper describes feasibility and patient satisfaction for an integrated treatment to address multiple health outcomes in a sample of older adults living in a low-income independent residence facility and their own homes in the community. Specifically, 30 older adults were offered the opportunity to participate in a feasibility study of different components of Activate for Life treatment targeting balance and physical strength (Otago Exercise Program), breathing retraining (Gentle Yoga and Yogic Breathing), and mental health (Behavioral Activation for Depression). Three treatment combinations were compared in a randomized repeated measures design to determine if adding components to the existing Otago program were feasible and if this affected patient satisfaction. Arm1: the Otago strength and balance program alone (n = 10); Arm 2: Otago + Gentle Yoga and Yogic Breathing (n = 10); and Arm 3: Otago + Gentle Yoga and Yogic Breathing + Behavioral Activation (we named this combination ‘Activate for Life’ n = 10). Dependent measures included recruitment rate, session completion characteristics, and satisfaction with the program. Overall, study and treatment components proved feasible, and participants reported high satisfaction with all 3 Arms.
Subcutaneous Emphysema Complicating Convalescent Stage of Measles in a Malnourished Indigent Child: A Case Report from North-western Nigeria.
Authors: Na'uzo Aliyu Mamman , Sanni Usman Abiola , Lawal Taslim Olatunde , Musa Tawakaltu Lilly , Gabriel Ojumo Opeyemi , Abdullahi Zainab , Habib Muhammad Ibrahim 
Published: September 2021

Abstract
Background: Measles is a highly infectious vaccine preventable viral disease that runs a devastating course in developing countries due to its association with malnutrition and poor immunization coverage. Among the complications of measles, pneumonia accounts for most measles-associated morbidity and mortality. However, subcutaneous emphysema is a rare complication of measles that can be challenging to manage and may portend poor outcome if untreated. Case presentation: We present a case of a 2yr old un-immunized rural dweller with massive subcutaneous emphysema comorbid with malnutrition complicating convalescent stage of measles. The child failed to improve with conservative management but responded to closed thoracostomy tube drainage (CTTD) through an underwater seal bottle with intermittent negative pressure wound therapy (NPWT). The child spent 47days on admission during which the treatment was supported by faith-based organization and social welfare unit of the hospital.ConclusionSubcutaneous emphysema is a rare complication of measles infection that can be challenging to manage especially when comorbid with malnutrition in an indigent child. Multi-disciplinary team approach and the use of CTTD with NPWT is an effective management measure which can shorten the duration of hospital stay.
Efficacy of BioFire FilmArray Gastrointestinal Panel (FGP) to Reduce Hospital Costs Associated With Contact Isolation: A Pragmatic Randomized Controlled Trial
Authors: DiDiodato Giulio , Allan Ashley , Bradbury Nellie , Brown Julia , Cruise Kelly , Jedrzejko Christopher , MacDonald Valerie , Pigeon Jessica , Sturgeon Amanda , Yellenik Daniel 
Published: September 2021

Abstract
Background: Molecular syndromic panels can rapidly detect common pathogens responsible for acute gastroenteritis in hospitalized patients. Their impact on both patient and healthcare system outcomes is uncertain compared to conventional stool testing. This randomized trial evaluates the impact of molecular testing on in-hospital resource utilization compared to conventional stool testing.Methods: Hospitalized patients with acute diarrheal illness were randomized 1:1 to either conventional or molecular stool testing with the BioFire FilmArray gastrointestinal panel (FGP). The primary outcome was duration of contact isolation, and secondary outcomes included other in-hospital resource utilization such as diagnostic imaging and antimicrobial use. Results: A total of 156 patients were randomized. Randomization resulted in a balanced allocation of patients across all 3 age strata (<18, 18-69, ≥70 years old). The proportion of positive stools was 20.5% vs 29.5% in the control and FGP groups, respectively (p=0.196). The median duration of contact isolation was 51 hours (interquartile range (iqr) 66) and 69 hours (iqr 81) in the conventional and FGP groups, respectively (p=0.0513). There were no significant differences in other in-hospital resource utilization between groups. Conclusions: There were no differences in in-hospital resource utilization observed between FGP and conventional stool testing groups. Trials Registration: ClinicalTrials.gov NCT04189874
Association Between Obesity-Related Dyspnea in Daily Living, Lung Function and Body Composition Analyzed by DXA: A Prospective Study of 130 Patients
Authors: Hagenburg Jean , Bertin Eric , Salmon Jean-Hugues , Thierry Aurore , Perotin Jeanne-Marie , Dormoy Valerian , Dury Sandra , Bolko Lois , Lebargy François , Deslee Gaetan , Launois Claire 
Published: September 2021

Abstract
Background Obesity is a risk factor for dyspnea. However, investigations of daily living obesity-related dyspnea are limited and its mechanisms remain unclear. We aimed to analyze the relationships between dyspnea in daily living, lung function, and body composition in patients with obesity.Methods One-hundred and thirty patients (103 women/27 men), candidate for bariatric surgery, with a mean ± SD Body Mass Index (BMI) of 44.8 ± 6.8 kg/m² were included. Dyspnea was assessed by the modified Medical Research Council (mMRC) scale. Comorbidities, laboratory parameters, pulmonary function tests, arterial blood gases, six-minute walk test (6MWT), handgrip strength, and DXA body composition were analyzed.Results Thirty-one percent of patients exhibited disabling dyspnea in daily living (mMRC ≥ 2). Compared with patients without disabling dyspnea (mMRC < 2), significant dyspnea (mMRC ≥ 2) was associated with a lower 6MWT distance (395 ± 103 m vs 457 ± 73 m, p<0.001), lower lung volumes including Expiratory Reserve Volume (42 ± 28 % vs 54 ± 27%, p=0.024), Vital Capacity (95 ± 14 vs 106 ± 15%, p<0.001) and Forced expiratory volume in one second (95 ± 13 vs 105 ± 15%, p=0.002), a higher BMI (48.2 ± 7.7 vs 43.2 ± 5.7 kg/m², p=0.001) and a higher percentage of fat mass in the trunk (46 ± 5 vs 44 ± 5 p=0.012) and android region (52 ± 4 vs 51 ± 4%, p=0.024). There was no difference regarding comorbidities (except hypertension), laboratory parameters, and sarcopenia markers between patients with (mMRC ≥ 2) and without (mMRC < 2) disabling dyspnea. Conclusion Dyspnea in patients with obesity is associated with a reduction in lung volumes and a higher percentage of fat mass in central body regions. How dyspnea and body composition may change with interventions like physical activity or bariatric surgery remains to be investigated. Trial Registration Reims University Hospital Institutional Review Board (IRB-17-10-2012).
Implementing the use of objective medication adherence data in routine clinical practice via the digital CFHealthHub platform: situation analysis and strategy development using the theoretical domains framework
Authors: Girling Carla , Packham Anna , Robinson Louisa , Arden Madelynne A , Hind Daniel , Wildman Martin J 
Published: September 2021

Abstract
Background Preventative inhaled treatments preserve lung function and reduce exacerbations in Cystic Fibrosis (CF). Self-reported adherence to these treatments is over-estimated. An online platform (CFHealthHub) has been developed with patients and clinicians to display real-time objective adherence data from dose-counting nebulisers, so that clinical teams can offer informed treatment support. Methods In this paper, we identify pre-implementation barriers to healthcare practitioners performing two key behaviours: accessing objective adherence data through the website CFHealthHub and discussing medication adherence with patients. We aimed to understand barriers during the pre-implementation phase, so that appropriate strategy could be developed for the scale up of implementing objective adherence data in 19 CF centres. Thirteen semi-structured interviews were conducted with healthcare practitioners working in three UK CF centres. Qualitative data were coded using the Theoretical Domains Framework (TDF), which describes 14 validated domains to implementation behaviour change. Results Analysis indicated that an implementation strategy should address all 14 domains of the TDF to successfully support implementation. Participants did not report routines or habits for using objective adherence data in clinical care. Examples of salient barriers included skills, beliefs in consequences, and social influence and professional roles. The results also affirmed a requirement to address organisational barriers. Relevant behaviour change techniques were selected to develop implementation strategy modules using the behaviour change wheel approach to intervention development. ConclusionsThis paper demonstrates the value of applying the TDF at pre-implementation, to understand context and to support the development of a situationally relevant implementation strategy. Contribution to the literature· Research indicates that the implementation of healthcare innovations may be more likely to succeed when context and theory are taken into consideration. · In this study, healthcare professionals identified barriers to two behaviours that were key to the implementation of a national Cystic Fibrosis (CF) healthcare innovation. By coding barriers to the Theoretical Domains Framework (TDF), a contextually relevant implementation strategy was developed, with a focus on clinician behaviour change. · The study highlights the challenges CF teams face when implementing new remote monitoring of medication adherence, and provides an important opportunity to apply the TDF in the pre-implementation phase of a healthcare innovation.
Adjuvant Chemotherapy Following Combined Induction Chemotherapy and Concurrent Chemoradiotherapy Improves Survival in N2-3-positive Nasopharyngeal Carcinoma Patients
Authors: Tao Hao-Yun , Liu Hui , He Cai-Xian , Li Ran , Du Kun-Peng , Yuan Ya-Wei , Zheng Rong-Hui 
Published: September 2021

Abstract
Objective: This study aimed to explore the clinical value of adjuvant chemotherapy (ACT) in locoregionally advanced nasopharyngeal carcinoma (LANC) following concurrent chemoradiotherapy (CCRT) and induction chemotherapy (ICT).Methods: We included 839 newly diagnosed LANC patients in the study. ICT plus CCRT (ICT+CCRT group) was administered to 443 patients and 396 patients who received ACT after receiving ICT plus CCRT (ICT+CCRT+ACT group). Univariate and multivariate Cox regression analyses were carried out in this study. Furthermore, to balance the study and control groups, propensity score matching (PSM) was applied.Results: 373 pairs of LANC patients were obtained after the PSM analysis. We found that ACT following ICT+CCRT had no significant effect on improving the survival of LANC patients. By further exploring the ICT+CCRT+ACT regimen, we excluded N0-1-positive patients and performed PSM in the ICT+CCRT and ICT+CCRT+ACT groups again. Each group consisted of 237 patients. Kaplan-Meier analysis revealed that there was a difference between the ICT+CCRT and ICT+CCRT+ACT groups in terms of the 5-year overall survival (OS) (78.9% vs. 85.0%, P = 0.034), disease-free survival (DFS) (73.4% vs. 81.7%, P = 0.029), and distant metastasis-free survival (DMFS) (84.9% vs. 76.0%, P = 0.019). In addition, the ICT+CCRT+ACT group had a higher incidence of grade 3-4 acute leukocytopenia/neutropenia.Conclusion: Compared with ICT+CCRT, ACT following ICT plus CCRT can reduce distant metastasis of N2-3-positive LANC and improve the OS and DFS of these patients, thus demonstrating higher clinical feasibility.
On the Physical Origin of the Semiannual 1 Component of Surface Air Temperature over 2 Mid-latitude and Subpolar Oceans
Authors: Yang Fucheng , Wu Zhaohua 
Published: September 2021

Abstract
With the understanding that seasonal cycle of the temperature are forced principally by the annually evolving solar irradiance, many previous studies have defined seasonal cycle of surface air temperature (SAT) as the sum of yearly-period sinusoidal component and its harmonics, especially semiannual component. In mid-latitude and subpolar regions, the ratio between the semiannual and annual components of solar irradiance is negligibly small but that of the SAT over oceans is not, which remains to be understood. In this study, a simple energy budget model including main energy sources and sinks of oceanic mixed layer is designed to understand this puzzle. It is revealed that, when the oceanic mixed layer is prescribed as a layer of constant depth, the phase and amplitude of the modeled SAT is not consistent with that of the observation. However, when the annually changing heat capacity of the oceanic mixed layer is included, both the amplitude and phase of the modeled SAT share these of the observed SAT, proving that the semiannual component of SAT over mid-latitude and subpolar oceans is a result of the heat capacity-varying oceanic mixed layer in response to annually evolving solar irradiance.
Irradiated Fibroblasts Increase Interleukin-6 Expression and Induce Migration of Head and Neck Squamous Cell Carcinoma
Authors: Suzuki Shinsuke , Toyoma Satoshi , Kawasaki Yohei , Yamada Takechiyo 
Published: September 2021

Abstract
Background
The cytotoxic effect of radiation plays an important role in the treatment of head and neck cancer. However, irradiation is known to lead to the migration of various cancer cells, including those of head and neck cancer. Recently, fibroblasts in the cancer microenvironment have been reported to be involved in this mechanism. Nevertheless, the mechanism underlying the migration of head and neck cancer cells remains unclear. The purpose of this study was to elucidate this migration mechanism induced by irradiation in terms of the interaction of head and neck cancer cells with fibroblasts.
Methods
We used the head and neck squamous cell carcinoma (HNSCC) cell lines SAS and FaDu as well as fibroblast cell lines. These cells were irradiated and their viability was compared. In fibroblasts, changes in interleukin-6 (IL-6) secretion caused by irradiation were measured by enzyme-linked immunosorbent assay (ELISA). The cell migration ability of cancer cells was evaluated via a migration assay using a semipermeable membrane. HNSCC cells were cocultured with irradiated and nonirradiated fibroblasts, and their migration ability under each condition was compared. We also examined the effect of IL-6 on the migration of HNSCC cells. Furthermore, to investigate the effect of fibroblast-derived IL-6 on the migration ability of HNSCC cells, we conducted a coculture study using IL-6 neutralizing antibody.
Results
Irradiation reduced the survival of HNSCC cells, whereas fibroblasts were resistant to irradiation. Irradiation also increased IL-6 secretion by fibroblasts. Migration of HNSCC cells was enhanced by coculture with fibroblasts and further enhanced by coculture with irradiated fibroblasts. We also confirmed that the migration of HNSCC cells was induced by IL-6. The enhanced migration of cancer cells caused by coculturing with fibroblasts was canceled by the IL-6 neutralizing antibody.
Conclusion
These results show that fibroblasts survive irradiation and induce the migration ability of HNSCC cells through increased secretion of IL-6.
NnLAC17, a Gene Related to Lignin Synthesis, is Involved in Adventitious Root Formation in the Seedlings of Lotus (Nelumbo Nucifera Gaertn)
Authors: libao Cheng , Chen Zhao , minrong Zhao , yuyan Han , Shuyan Li 
Published: September 2021

Abstract
BarkgroundAdventitious roots (ARs), which are considered as an important member of root system, have an unmatched status in plant growth and metabolism due to the degeneration of primary roots in lotus. The regulation of AR formation was previously revealed and multiple factors were recognized to be involved in this biological process. ResultsIn the present study, we sought to assess the effect of sucrose on AR formation. Based on our results, lignin metabolism, which is regulated by the sucrose signal transduction pathway, is involved in AR development. The lignification degree of the AR primordium was weaker in plants treated with 20 g/L sucrose than in control plants. However, based on the microstructural observation of the AR developmental process, 50 g/L sucrose promoted the lignification process. Lignin content, including monomer and polymer lignin, was determined in the present study. Compared with control plants, the monomer (containing 30%–45% S type and 55%–70% G type) and polymer lignin contents were lower in plants treated with 20 g/L sucrose and higher in plants treated with 50 g/L sucrose. The precursors of monomer lignin were identified in four libraries of differential developmental stages in seedlings using LC-MS/MS technique. The contents of four metabolites, including p-coumaric acid, caffeate, sinapinal aldehyde and ferulic acid for monomer lignin synthsis were lower in the GL50 library than in the GL20 library. Further analysis revealed that the gene expression of these four metabolites had no novel difference in the GL50/GL20 libraries. However, NnLAC17, a gene involved in polymer lignin synthesis, had a higher expression in the GL50 library than in the GL20 library. ConclusionsTherefore, NnLAC17 was cloned, and the overexpression of NnLAC17 was found to directly result in a decrease in AR number in transgenic Arabidopsis plants. These findings suggest that NnLAC17, which is relevant to lignin synthesis, is involved in AR formation in lotus seedlings.
Genome-wide Analysis of the WUSCHEL-related Homeobox Gene Family and Functional Characterization of VcWOX4b Regarding the Inhibition of Adventitious Root Formation in Blueberry (Vaccinium Spp.)
Authors: Gao Yudi , Li Ke , Yin Yahong , Li Yongqiang , Zong Yu , Liu Xianglei , Liu Jian , Zhu Youyin , Guo Weidong 
Published: September 2021

Abstract
Background: Blueberry (Vaccinium corymbosum L.) is one of the most important commercial fruit tree species. The development of high-quality seedlings is a prerequisite for fruit production. Stem cutting and tissue culture methods are widely applied for propagating blueberry seedlings. Both methods require adventitious roots (ARs), indicating ARs are critical for vegetative propagation. However, the underlying factors and molecular mechanisms regulating blueberry AR formation remain relatively unknown. Results: In this study, the rooting abilities of differentially lignified cuttings from various cultivars or the same cultivars cultured differently were evaluated following an indole-3-butyric acid (IBA) treatment. Field-grown semi-lignified and tissue culture-grown cuttings formed ARs, but the latter had more pericycle and secondary xylem cells and formed ARs more easily and faster. WUSCHEL-related homeobox genes are commonly involved in vascular tissue development and early root meristem maintenance. On the basis of the available Vaccinium corymbosum genome data, 29 putative WOX genes with conserved homeodomains were identified and divided into three major clades (modern/WUS, intermediate, and ancient). These 29 WOX genes were differentially expressed in the root, shoot, leaf, flower bud, and fruit. Additionally, a qRT-PCR analysis revealed that five selected VcWOX genes were responsive to an IBA treatment during AR formation. Accordingly, VcWOX4b was functionally characterized. The overexpression of VcWOX4b in transgenic tobacco inhibited AR formation by altering vascular cell division and differentiation and the indole-3-acetic acid (IAA):cytokinin (CTK) ratio. These observations suggest that VcWOX4b regulates the IAA:CTK ratio to promote primary xylem cell differentiation, thereby inhibiting AR formation. However, an IBA treatment can induce AR formation by inhibiting VcWOX4b expression. Conclusions: Current study elucidates the rooting abilities of various cultivars and the cytological characters of influence on AR formation of blueberry cuttings, which may provide novel insights into the selection of high-quality blueberry cuttings. VcWOX4b, VcWOX8/9a, VcWOX11/12c, and VcWOX13b might regulate blueberry AR formation in an IBA-dependent manner. Ectopic expression of VcWOX4b modulated the IAA:CTK ratio to promotes primary xylem cell differentiation, but inhibit secondary xylem cell differentiation, ultimately leading to decreased AR formation.