bluuebunny/crossref_metadata_2025_split huggingface dataset:
A methodology to transform business goals and objectives into software requirements
Authors: Čaplinskas Albertas 
Published: December 2021

The paper proposes a methodologyhow to transform business goals and objectives into supportingsoftware requirements. The proposed approach is based on ideas beyond the Zachman’s framework. However both lines and columns of the Zachman’s framework are interpreted in quite different way. The left column of the proposed framework is Why column. At the top level it describes business goals and objectives. Other columns are interpreted in the way allowing formulating requirements that step-by-step can be flowdown into detailed and measurable software requirements. For example, the Who column associates business goals and subgoals with the particular roles (positions) that in some way contribute to their implementation and for each role describes performing business tasks. User interface requirements and usability requirements are derived later from this information. The main advantage of the proposed methodology is the possibility to ensure better strategic alignment of software requirements.
A Clinical Monitoring Approach for Early Onset Sepsis: A Community Hospital Experience
Authors: Bain Lisa , Sivakumar Dharshi , McCallie Katherine , Balasundaram Malathi , Frymoyer Adam 
Published: December 2021

Abstract

BACKGROUND
A serial clinical examination approach to screen late preterm and term neonates at risk for early onset sepsis has been shown to be effective in large academic centers, resulting in reductions in laboratory testing and antibiotic use. The implementation of this approach in a community hospital setting has not been reported. Our objective was to adapt a clinical examination approach to our community hospital, aiming to reduce antibiotic exposure and laboratory testing.

METHODS
At a community hospital with a level III NICU and &gt;4500 deliveries annually, the pathway to evaluate neonates ≥35 weeks at risk for early onset sepsis was revised to focus on clinical examination. Well-appearing neonates regardless of perinatal risk factor were admitted to the mother baby unit with serial vital signs and clinical examinations performed by a nurse. Neonates symptomatic at birth or who became symptomatic received laboratory evaluation and/or antibiotic treatment. Antibiotic use, laboratory testing, and culture results were evaluated for the 14 months before and 19 months after implementation.

RESULTS
After implementation of the revised pathway, antibiotic use decreased from 6.7% (n = 314/4694) to 2.6% (n = 153/5937; P &lt; .001). Measurement of C-reactive protein decreased from 13.3% (n = 626/4694) to 5.3% (n = 312/5937; P &lt; .001). No cases of culture-positive sepsis occurred, and no neonate was readmitted within 30 days from birth with a positive blood culture.

CONCLUSIONS
A screening approach for early onset sepsis focused on clinical examination was successfully implemented at a community hospital setting resulting in reduction of antibiotic use and laboratory testing without adverse outcomes.
Fermentación extractiva de melazas
Authors: Caicedo Luis A. , González Omar , Rico Yolanda , Correal Leonor de 
Published: December 2021

Una cepa de Saccharomyces cerevisiae aislada de levadura Fleishman, fue adaptada para fermentar melaza en presencia de solventes como Kerosene, destilados de gasolina y n-Heptano, Fueron realizados ensayos iniciales para seleccionar el solvente, observándose que el Kerosene presenta menor efecto inhibitorio. La fermentación de la melaza fue realizada con mezclas de solvente y mostró en relaciones 1 a 1 y 4 a 1 respectivamente y concentraciones iniciales de azúcar equivalentes a 12 y 16 grados Brix. Se corroboró el efecto inhibitorio que ejerce el producto (etanol) en la fermentación, debido a que concentraciones altas de solvente producen mayor conversión del azúcar y por consiguiente mayor rendimiento. Para altas concentraciones de azúcar la conversión está limitada por la solubilidad del alcohol en el solvente. Comparando los coeficientes de distribución de la mezcla etanol-agua-kerosene con los obtenidos en la mezcla mosto fermentado-kerosene, se pudo observar una mayor solubilidad del etanol en la fase orgánica de la última, debido probablemente a la presencia de sales en el medio.
Evaluation of Maize â€œTurdaâ€ Germplasm as Sources of Earliness in Breeding Programs
Authors: HAS Ioan , HAS Voichița , Copandean Ana , SCHIOP Teodora , ROTAR Carmen 
Published: December 2021

Evaluation of the early maize (Â Zea mays L.) germplasm is important for the development of new inbred lines and commercial hybrids adapted to cooler regions. Choice of populations to use in improving elite maize hybrids is a critical decision in maize breeding programs. Our objectives were: I) to examine the variation for earliness in a set of 256 local populations, 56 synthetic populations and 504 inbred lines; II) to determine the performance and heterosis of this germplasm; III) to identify the genotypes (local populations, inbred lines) for the initiation of the primary cycle for directional selection for the studied characters. Seven synthetic populations and six inbred lines formed the base material of this genetic study. The seven synthetic populations and their topcrosses to four inbred lines: two flint inbred lines (TD 233 and CO 255) and two dent inbred lines (TC 184 and TC 209) and also a diallel type p(p-1) system with 30 single-cross hybrids and the six parental forms were evaluated at four environments in: two years 2009 and 2010 and two locations Turda and Targu- Mures. The highest values of additive effects for grain dry matter content were recorded at: Tu Syn Mara (ÄÂ n = +1.80), Tu SRR 5D (2I) (1) (Än = +0.62) and Tu Syn 1 (Än = +0.45). Therefore, Tu Syn Mara, Tu SRR 5D (2I)(1) and Tu Syn 1 produced hybrids with the most early maturity. The highest general combining ability (GCA) for dry matter accumulation in grains has registered the inbred lines TC209 (Ä = +1.36) and TC208 (Ä = +0.71).
The Influence of Mineral Fertilization on the Distribution of Nutrients in the Soil
Authors: PáŽSLEA Daniela , SALA Florin 
Published: December 2021

An important factor in sustaining agricultural yield, mineral fertilization is at the same time one of the factors that causes changes in the chemical characteristics of the soils. Nutriment mobility in the soil is different: it is higher in the nitrogen case and lower in that of phosphorusâ€™. We assessed the changes in the macroelement content of the upper soil horizon when applying mineral fertilizers on winter wheat crops. We tested different doses and combinations of complex mineral fertilizers, NPK (S) fertilizers with zinc [15/15/15(+3+Zn)] and ammonium nitrate (35:0:0). The determinations were made for two depths, 0 - 10 cm and 10 - 20 cm, in order to observe the mobility of the nutrients for each soil profile. Nitrogen content vacillates between 0.15 -Â 0.25% Â± 0.008 for 0 - 10 cm depth and 0.16 -Â 0.23% Â± 0.006. Phosphorus is found between 25.8 - 54.64 ppm Â± 3.109 for a depth of 0 - 10 cm and 30.8 - 28.14 ppmÂ Â± 1.406 for 10 - 20 cm. Potassium content varies between 193.8 - 384.64 ppm Â± 25.627 for the depth of 0 - 10 cm and 205.45 -Â 327.14 ppm Â± 15.135 for the depth of 10 - 20 cm. While analysing the results on the macroelement content and mobility in the soil horizon under research in terms of multiple correlations, we got very strong positive correlation for nitrogen and potassium and weak correlation for phosphorus.
Protection as a Mean to Increase the Sustainability of Wood Structures
Authors: CORDUBAN Calin , BOCHICCHIO Giovanna , POLASTRI Andrea , CECCOTTI Ario 
Published: December 2021

Timber has been rediscovered as the building material of choice in recent years, especially in industrialised countries, with the shift of focus on attitudes towards sustainability that include use of natural resources and reduction of COÂ 2 emissions in manufacturing building materials. The environmental qualities of wood (energy-efficiency, healphy building material, ability to be recycled) are matched by few materials used in constructions nowadays, makeing it suitable for a wide range of applications. The combustibility of wood is limiting its use in construction, an important weakness in terms of sustainability, as health and cost issues constitute essential conditions in sustainability assessment methods. Arguably, fire safety constitutes the foremost precondition in choosing wood as the building material. In the case of fire, wood burns on the surface, releases energy and contributes to the fire propagation and spread of smoke. In order to insure greater safety for timber constructions, both passive and active measures of fire protection can be implemented, with the main objectives of improving the security of occupants, limitations of financial loss, protection of the environment in the case of fire. Despite the fear of using wood, the material has a better behavior in terms of fire than assumed, and even with structures more susceptible at fire risks, such as platform framing, measures can be taken in order to improve safety, as further explained in the article. The article analyses the concept of sustainability and the extent to which timber constructions observe these criteria, focusing on the means of increasing safety by fire protection methods with respect to the environment.
Sensory Evaluation of Minimally Processed Parsley (Petroselinum crispum), Dill (Anethum graveolens) and Lovage (Levisticum officinale) Stored at Refrigeration Temperatures
Authors: CÄ‚TUNESCU Giorgiana Mihaela , TOFANÄ‚ Maria , MUREȘAN Crina , DAVID Adriana , ST Ä‚NILÄ‚ Sorin 
Published: December 2021

Minimally processed fresh fruit, vegetables and aromatic herbs are a becoming more popular because they satisfy consumersâ€™ need for time and healthy nutrients. But, even applying packaging and refrigeration their shelf life is short. The main quality losses that occur along storage are changes in colour, texture and flavour. In consequence, it is important to establish how these factors affect acceptance and preference of minimally processed fresh plant food. So, the aim of the present paper is to evaluate the effect of storage at refrigeration temperature on some quality characteristics of the most important minimally processed Romanian seasoning herbs. The herbs under study were parsley, dill and lovage. A grid of attributes of fresh herbs was developed. The herbs, sealed in polyethylene bags, were stored at 4Â°C for 12 days. The evaluation of quality characteristics color, texture and flavor, on a scale of 1 to 5 was done in the 1 st, 5 th, 8th and 12day. In order to evaluate the average quality of the herbs, a quality number was used. Starting form herbs scores in the first day, a sensory profile was determined. This was maintained along the storage period. Even though, scores decreased along the storage period, there were no statistically significant differences for any of the parameters under study in the days taken into consideration. Quality number along the storage period do not differ statistically for none of the three herbs. For minimal processed parsley, dill and lovage the maximum shelf-life was estimated to be 23.3 days, 13.7 days and 15.3 days respectively.Â Â Â th
Comparative Fingerprint of Glucosinolates from Brassica Vegetables Using HATR/FT-MIR Spectroscopy
Authors: VICAS Simona Ioana , FETEA Florinela , CARBUNAR Mihai , SOCACIU Carmen 
Published: December 2021

Glucosinolates (Î²-thioglucoside-N-hydroxysulphates) are very important plant secondary metabolites containing a Î²-D-glucopyranose residue linked to a sulfur atom (i), or to a (Z)-Nhydroximinosulfate ester (ii) or a variable R group (iii) with different side-chain substituents which give their structural diversity.Â Â The objective of the present research was to compare the fingerprint of 9 standard pure glucosinolates and Brassica vegetables extracts of broccoli, cauliflower and kohlrabi, cultivated in North-West of Romania, using the Fourier Transform Infrared Spectroscopy (FTIR). The FTIR fingerprint was recorded for both, desulpho - standards of glucosinolates (sinigrin, gluconapin, progoitrin, glucoiberin, glucoraphanin, glucotropaeolin and glucobrassicin) and intact glucosinolates (sinigrin and glucotropaeolin). The extraction of glucosinolates was made according to the EU official method (EEC Regulation N. 1864/90). The FTIR spectra for standards and Brassica dried extracts were recorded in the MIR region, from 4000 and 900 cm-1. The results obtained show that HATR/FT-MIR spectroscopy can be used as a fast method for the quantification of total glucosinolates considering the IR absorption at 800Â Â Â cmor the region area of 750-900 cm-1, is the most suitable.Â The HATR/FT-MIR is non-destructive, cheap and fast method to fingerprint, to predict and to quantify the glucosinolate composition of Brassica vegetables. Â
Zinc in Food Chain
Authors: GERGEN Iosif , HARMANESCU Monica 
Published: December 2021

Zinc is an essential trace element widespread in soil, water, flora and fauna. In the food chain, soil is the main source of zinc. The objective of the work is to summarize the nutritional and toxicity data about the spread of Zn in soils and food from vegetal or animal origin. Zinc toxicity in the plant kingdom was rarely detected (at concentrations > 300 mg kg-1), due mainly by plant capacity to regulate homeostasis accumulation of heavy metals, including zinc. Zn contents in plant foods are between 2-10 mg kg-1, the highest concentrations can be found in roots and seeds.Â Â
Biological Control of Soil-borne Phytopathogenic Fungi and their Mycotoxins by Soil Fauna
Authors: SCHRADER Stefan , WOLFARTH Friederike , OLDENBURG Elisabeth 
Published: December 2021

Yield loss through harmful fungi is a serious problem in crop production worldwide. Cereal residuesÂ likeÂ strawÂ areÂ frequentlyÂ infectedÂ by FusariumÂ fungi,Â whichÂ produceÂ mycotoxinsÂ like deoxynivalenolÂ (DON).Â MycotoxinsÂ leadÂ toÂ qualityÂ lossesÂ inÂ cereal-basedÂ foodÂ andÂ feedÂ which endangers human and animal health. Especially under conservation tillage, when mulching techniques are applied to protect soil from erosion, run-off etc., residues should be efficiently degraded to protect the currently cultivated crop from fungal infection and mycotoxin contamination. The objective of this reviewÂ isÂ toÂ giveÂ anÂ overviewÂ onÂ whichÂ roleÂ decomposingÂ soilÂ faunaÂ playsÂ inÂ theÂ fateÂ of Fusarium fungiÂ andÂ there mainÂ mycotoxinÂ DONÂ inÂ theÂ soilÂ system.Â Generally,Â soilÂ faunaÂ benefitsÂ from conservation tillage compared to conventional tillage. Results from experiments in the laboratory and fieldÂ revealedÂ thatÂ earthwormsÂ asÂ primaryÂ andÂ secondaryÂ decomposersÂ asÂ wellÂ as fungivorous collembolansÂ andÂ soilÂ nematodesÂ contributeÂ toÂ theÂ ecosystemÂ servicesÂ ofÂ pathogenÂ depressionÂ and toxin degradation with respect to Fusarium and DON. Fusarium seems to be an attractive food source. Furthermore, the mycotoxin DON does not cause any harm to the soil fauna tested. Key factors for the controlÂ of FusariumÂ developmentÂ byÂ antagonisticÂ soilÂ faunaÂ are:Â (1)Â interactionÂ withÂ soil microorganisms; (2) interaction of soil fauna species; (3) soil texture; (4) residue exposure. Ecosystem services of antagonistic soil fauna are vital to crop production and the functioning of agroecosystems. They will be discussed in a broader context of soil health and conservation tillage.
Study on the Action of the Aliin From Garlic (Allium sativum L.) against Plant Pathogens
Authors: BORDEA Daniela , OROIAN Ioan , ODAGIU Antonia , MILÄ‚ȘAN Adrian 
Published: December 2021

OneÂ ofÂ theÂ mostÂ importantÂ benefitsÂ ofÂ usingÂ plantÂ derivedÂ toolsÂ inÂ fightingÂ againstÂ plant bacteria and fungi attack, is their environmentally safety, much higher compared to synthetic products, simultaneouslyÂ withÂ offeringÂ importantÂ therapeuticÂ benefits.Â GarlicÂ hasÂ anÂ increasingÂ roleÂ on unconventional phytopathogens fight, especially within integrated pest management systems. Even its preventive and curative effects on both human and vegetables is well known from ancient times, the scientific basis of using garlic as nutraceutic with valuable action on human health and/or alternative agentÂ againstÂ plantÂ pathogens,Â wasÂ scientificallyÂ settledÂ onlyÂ inÂ lastÂ decades. TheÂ presentÂ work attemptsÂ toÂ emphasize aÂ pictureÂ concerningÂ the garlicÂ aliinÂ component,Â whichÂ conferÂ theÂ plant antibacterial and antifungicide properties. Our study strengthens the previous assessments concerning synergisticallyÂ actionÂ ofÂ mainÂ organo-sulphurÂ compoundsÂ from AlliumÂ sativumÂ L.Â resultingÂ in antifungicideÂ andÂ antibacterialÂ effects.Â TheÂ intensityÂ andÂ efficacyÂ ofÂ thoseÂ effectsÂ dependsÂ atÂ large extentÂ onÂ garlicÂ extractsÂ natureÂ andÂ theirÂ processingÂ technology.Â AmongÂ updatedÂ actionsÂ ofÂ garlic different extracts we mention: antibacterial properties against both Gram positive and Gram negative bacteria, fight against yeast-like fungi and other fungi varieties, in control of particular plant diseases, control of warms, aphids, Colorado beetles, mosquitoes. The present available knowledge concerning theÂ aliinÂ action againstÂ aÂ largeÂ spectrumÂ ofÂ bacteria,Â fungi,Â particularÂ plantÂ diseases,Â andÂ pestsÂ will need a wider approach that involves the development of molecular biology tools, in order to identify the complex mechanisms of interaction between aliin and plant pathogens.
Polycyclic Aromatic Hydrocarbons in Sewage Sludge from Cluj-Napoca Wastewater Treatment Plant
Authors: ALHAFEZ Livia , MUNTEAN Nicoleta , MUNTEAN Edward , RISTOIU Dumitru 
Published: December 2021

Polycyclic aromatic hydrocarbons (PAHs) are organic compounds widely distributed in theÂ environment.Â InÂ theÂ presentÂ work, concentrationsÂ ofÂ theseÂ organicÂ compoundsÂ inÂ sludge samplesÂ fromÂ Cluj-NapocaÂ wastewaterÂ treatmentÂ plantÂ areÂ reported.Â TheÂ objectiveÂ wasÂ to investigate PAHs in sludge from wastewater treatment plant and to assess their potential for land application. Primary sludge, fermented sludge, fermented concentrated sludge, anaerobic-digested dehydratedÂ sludgeÂ andÂ rejectionÂ waterÂ samplesÂ wereÂ collectedÂ monthlyÂ fromÂ DecemberÂ 2012. Ultrasonic assisted extraction with hexane was used, being followed by filtration and concentration toÂ drynessÂ inÂ aÂ rotaryÂ evaporator;Â theÂ obtainedÂ residueÂ wasÂ redisolvedÂ inÂ acetonitrile.Â High performanceÂ liquidÂ chromatographicÂ analysisÂ wasÂ achievedÂ usingÂ anÂ AgilentÂ 1100Â system consisting in a solvent degasser, a quaternary pumping system, an autosampler, a column oven, a diode-arrayÂ detectorÂ andÂ aÂ fluorescenceÂ detector.Â SeparationsÂ wereÂ accomplishedÂ usingÂ an EnvirosepÂ PPÂ columnÂ withÂ acetonitrile:waterÂ asÂ mobileÂ phaseÂ (45:55Â v/v).Â DetectionÂ limitÂ was 0.001 ï­g/Â kg,Â withÂ goodÂ linearitiesÂ for allÂ PAHs,Â withÂ correlationÂ coefficientsÂ higherÂ thanÂ 0.998. PAHs with four rings appeared to be the primary components in most of the tested sludge samples, theÂ highestÂ concentrationÂ levelsÂ beingÂ inÂ anaerobic-digestedÂ dehydratedÂ sludgeÂ samples.Â The obtained results can be helpful for the regional policy makers to make proper decisions on treating theÂ increasingÂ amountÂ ofÂ sewageÂ sludge,Â toÂ provideÂ practicalÂ referenceÂ forÂ establishingÂ threshold valuesÂ ofÂ PAHsÂ forÂ landÂ applicationÂ ofÂ sludge,Â knowingÂ thatÂ theÂ practiceÂ ofÂ recyclingÂ sewage sludge onto agricultural lands poses an additional risk of soil contamination with PAHs.
The Results of Cultivating the Species Agastache foeniculum (Pursh) Kuntze at Jucu, CJ
Authors: DUDA Marcel , MATEI Cristina FiruÅ£a , Vá‚RBAN Dan , MUNTEAN Sorin , MOLDOVAN Cristina 
Published: December 2021

Agastache foeniculum is a recent species cultivated in Romania. The species has the advantage that it can withstand low winter temperatures in the Transylvanian Plain, up to -25Âº C in soil covered with snow. Another major advantage of the species is that from itsÂ total mass, the plant foliage prevails which provides feedstock production materials for medicinal purposes. In the research conducted in 2011-2012 in the experimental field of Jucu were pursued issues regarding morphology, biology and plant phenology as well as productivity elements and finally the production of herba which can be done by the species in two periods of planting and three densities. It was cultivated a local population through seedling in two periods (26.04.2011 and 21.05.2011) at densities of 47 619 plants/ha (30 cm x 70 cm), 35 714 plants/ha (40 cm x 70 cm) and 28 517 plants/ha (50 cm x 70 cm). The experiences location was done by the method of subdivided parcels with 2 factors (time and planting density) in three repetitions. The surface of the experimental plot was 3 m2. Statistical interpretation was made by variance analysis method with one, two, and three factors and interpretation of the results, highlighting the significance of differences after the multiple comparisons test (Duncan test) and Student test. From measurements made â€‹â€‹at green plants it resulted that leaves represent a significant share of 37.98% of the total mass of the plant, 30.8% branches, main stem 10.44% and 20.78% inflorescences . If dried plant leaves have the highest share from the total plant of 35.89%, followed by branches (25.75%), flowers (19.04%) and 19.32% stems. The results justify the extension of the cultivation of this plant in the Transylvanian Plain, harvested herba with an important phytotherapy value.
MiRNA‐29a serves as a promising diagnostic biomarker in children with temporal lobe epilepsy and regulates seizure‐induced cell death and inflammation in hippocampal neurons
Authors: Wu Yifei , Zhang Yanrui , Zhu Shuxia , Tian Chunmei , Zhang Yanyan 
Published: December 2021

AbstractObjective. Temporal lobe epilepsy (TLE) in children is one of the most common refractory epilepsies. MicroRNAs (miRNAs) show abnormal expression in neurological disorders. The objective of this study was to determine changes in expression and the role of miR‐29a in children with TLE.Methods. Sixty‐five TLE patients and 70 normal controls were recruited. The levels of miR‐29a were quantified using qRT‐PCR. An in vitro TLE cell model was established using primary hippocampal cells cultured in magnesium‐free medium. Cell viability, cell apoptosis and inflammatory cytokine concentrations were evaluated. The luciferase reporter assay was applied to confirm the target gene, HMGB1.Results. A low level of MiR‐29a expression was observed in the serum of children with TLE, which demonstrated a negative association with the concentration of serum TNF‐α, IL‐6, and IFN‐γ. The level of MiR‐29a demonstrated high specificity and sensitivity in children with TLE. A low level of expression of miR‐29a was also detected in the TLE cell model. MiR‐29a over‐expression reversed the decreased cell viability induced by TLE, and alleviated cell apoptosis. Release of TNF‐α, IL‐6, and IFN‐γ induced by TLE was also inhibited by miR‐29a over‐expression. HMGB1, which was downregulated in the serum of TLE patients, was shown to be a target gene of miR‐29a, and negatively correlated with miR‐29a level.Significance. The downregulation of serum miR‐29a may serve as a non‐invasive diagnostic biomarker for children with TLE. MiR‐29a may be involved in the pathogenesis of TLE through regulation of neuronal apoptosis and neuroinflammation via targeting HMGB1.