bluuebunny/crossref_metadata_2025_split huggingface dataset:
About Resource Approach to the formation of the industrial policy of the enterprise
Authors: Игнатова Л.Н. , Девяткин О.В. , Болкина Г.И. 
Published: January 2021

Охарактеризованы особенности ресурсного подхода в формировании промышленной политики, сформулированы основные задачи промышленного развития российских предприятий. Ресурсный подход позволяет иметь самые различные модификации рассматриваемых критериев в зависимости от факторов, влияющих на развитие промышленного потенциала предприятий и организаций. Рассмотрен комплекс действующих нормативно-правовых актов. Предложены управленческие алгоритмы решения проблем стратегического планирования.
The features of the resource approach in the formation of industrial policy are characterized, the main tasks of the industrial development of Russian enterprises are formulated. The resource approach allows you to have a variety of modifications of the considered criteria, depending on factors affecting the development of the industrial potential of enterprises and organizations. A set of existing legal acts is considered. Management algorithms for solving strategic planning problems are proposed.
Improvement of the property management system at the municipal level
Authors: Рожков Е.В. 
Published: January 2021

В статье анализируются данные по сделкам с земельными участками частных лиц, индивидуальных предпринимателей и коммерческих компаний, а также изъятия недвижимости. Автором рассмотрен вопрос о целесообразности проведения национализации на местном уровне в виде изъятия собственности. Рассмотрены преимущества и недостатки проходящих сделок организованными муниципальными органами власти. Представлен промежуточный вывод, говорящий о правоотношениях между частным лицом и муниципалитетом, в которых нет ни равноправия, ни свободы волеизъявления частного лица.
The article provides the analyzes data concerning deals with land plots of individuals, individual entrepreneurs and commercial companies, as well as real estate forfeitures. The author considers the feasibility of nationalization at the local level represented as property forfeiture. The advantages and disadvantages of deals being established by municipal authorities are considered within. The intermediate conclusion describing legal relations between a private person and the municipality within which there is neither equality, nor freedom of will of a private person is presented therein.
Domestic and foreign models of science cities development
Authors: Сафронова Е.С. 
Published: January 2021

Технополис (или, как подобные образования именуются в России, «наукоград») - это город, на территории которого традиционно располагаются высшие учебные заведения, технопарк, научно-исследовательские учреждения, жилые зоны с развитой и подходящей для жизни и работы инфраструктурой. Цель подобной городской территории - это объединение совокупных систем информации на единой зоне для научного совершенствования, кроме того, синтез науки с производством передовых технологий с обеспечением надлежащей среды для результативного труда. Только целесообразно и разумно спроектированные, а затем воздвигнутые технополисы/наукограды обеспечат прирост новейших производственных отраслей и технологических объектов.
Technopolis (or, as such entities are called in Russia, «Naukograd») is a city that traditionally houses higher education institutions, a Technopark, research institutions, and residential areas with developed and suitable infrastructure for living and working. The purpose of such an urban area is to combine the aggregate information systems in a single area for scientific improvement, in addition, the synthesis of science with the production of advanced technologies to provide an appropriate environment for productive work. Only expediently and intelligently designed and then erected technopolises / science cities will ensure the growth of the latest production industries and technological facilities.
Exploring the feasibility of integrating big data and blockchain technologies
Authors: Кузнецов А.И. 
Published: January 2021

Проведен анализ требований к обработке больших данных с использованием технологии блокчейн, показано, что в ряде проектов эти технологии, несмотря на различие архитектур, можно использовать совместно. Поставлена задача создать в компьютерной среде модель, которая показывает принцип обработки больших данных о продажах недвижимости на основе децентрализованной платформы технологии блокчейн. Определены архитектура и характеристики контрактов для микросервисов распределенного приложения.
An analysis of the requirements for processing big data using blockchain technology is carried out it is shown that in a number of projects these technologies, despite the difference in architectures, can be used together. The task is to create a model in a computer environment that shows the principle of processing big data on real estate sales on the basis, of a decentralized blockchain technology platform. The architecture and characteristics of contracts for microservices of a distributed application are defined.
Multiused carbon-ceramic materials
Authors: Ларионов Н.В. 
Published: January 2021

Мировые стремления к использованию космических аппаратов многоразового использования требует разработки и новых материалов. Углерод-керамические материалы обладают рядом специфических характеристик, которые позволяют рассматривать эти материалы как перспективные для использования в авиа и ракетостроении. Специфичность их свойств связана с методом получения и составом материала. Углеродные волокна обеспечивают высокие физико-механические показатели, а матрица из карбида-кремния повышает окислительную стойкость, даже в окислительной среде.
The world's desire to use reusable space vehicles requires the development of new materials. Carbon-ceramic materials have a number of specific characteristics that allow us to consider these materials as promising for use in aviation and rocket science. The specificity of their properties is related to the method of preparation and composition of the material. Carbon fibers provide high physical and mechanical properties, and a silicon-carbide matrix increases oxidative resistance, even in an oxidizing environment.
Defining the nomenclature of quality indicators aviation technology for military purposes
Authors: Усачев Д.В. 
Published: January 2021

В статье определена номенклатура показателей качества авиационной техники военного назначения, а также проведена их классификация по характеризуемым свойствам.
The article defines the nomenclature of quality indicators of military aviation equipment, as well as their classification by characterized properties.
Improving the performance of large databases and application services operating on their basis
Authors: Аббасов Э.М. , Польшин С.Н. 
Published: January 2021

Исследованы функции информационной системы сервис-ориентированной архитектуры. Проанализированы действия лояльных и нелояльных к прикладным веб-сервисам системы интернет-пользователей и данные логов интернет-пользователей. Поставлена задача разработать базу данных для исследуемой информационной системы и повысить ее производительность путем масштабирования, репликации, секционирования, вертикального и горизонтального шардинга. Приведены результаты разработки базы данных для хранения и обработки логов поведения интернет-пользователей.
The functions of the information system of service-oriented architecture are investigated. The actions of the systems of Internet users that are loyal and disloyal to applied web services are analyzed, as well as the data of Internet users' logs. The task is to develop a database for the information system under study and increase its efficiency by scaling, replication, sectioning, vertical and horizontal sharding. The results of developing a database for storing and processing logs of Internet user behavior are presented.
Modeling of the optimal level of remedies for safety facility
Authors: Вилисов В.Я. , Клепко А.Е. 
Published: January 2021

В статье представлены результаты моделирования взаимодействия двух сторон с противоположенными интересами в контексте информационной безопасности объекта типа помещения для проведения совещаний. Модель взаимодействия сторон позволяет найти компромисс между затратами на обеспечение безопасности и теми потерями, которые могут возникнуть при потере того или иного объема информации об обсуждаемом в помещении проекте. На основе построенных моделей выполнены расчеты по данным, близким к реальным.
The article presents the results of modeling the game interaction of two parties with opposing interests in the context of information security of an object such as a room for meetings. The interaction model of the parties allows us to find a compromise between the costs of ensuring security and those losses that may occur when a loss of a certain amount of information about the project being discussed in the premises is lost. Based on the constructed model, calculations based on data close to real are performed.
Features of creating and modernizing a structured cable system for a rocket and space industry enterprise
Authors: Мороз А.П. , Емельянов А.Д. 
Published: January 2021

Рассматриваются особенности создания и модернизации структурированной кабельной системы на примере предприятия ракетно-космической отрасли. Проанализирована специфика предприятия. Показана целесообразность создания комбинированной системы на основе проводной техники и радиолинии.
The article considers the features of creating and modernizing a structured cable system based on the example of a rocket and space industry enterprise. The specifics of the enterprise are analyzed. The expediency of creating a combined system based on wire technology and radio lines is shown.
Development of structural and functional models of the technological process of manufacturing carbon-ceramic composites by the method of melt infiltration
Authors: Волкова В.А. , Волков В.С. 
Published: January 2021

В статье рассмотрены принципы использования процессов жидкофазной технологии для решения задач научно-технического прогресса и использования передовых технологий. В ходе ознакомления с методами моделирования был выбран метод IDEF3 как наиболее оптимальный для решения поставленных задач. Разработаны модели технологического процесса получения углерод-керамического композиционного материала методом пропитки расплавами, которые не были представлены ранее в литературных данных. Представлены рекомендации по практическому использованию полученных результатов работы.
The article discusses the principles of using liquid-phase technology processes to solve the problems of scientific and technological progress and the use of advanced technologies. During familiarization with the modeling methods, the IDEF3 method was chosen. The developed models of the technological process for producing a carbon-ceramic composite material by the method of impregnation with melts, which were not previously presented in the literature. Recommendations on the practical use of the results are presented.
The castration level of testosterone and hormonal resistance of prostate cancer in androgen deprivation therapy
Authors: Rusakov I. G. , Gritskevich A. A. , Baitman T. P. , Mishugin S. V. 
Published: January 2021

This review is dedicated to the impact of modern achievements on the definition and diagnostics of castration-resistant prostate cancer (PCa) (CRPC), prognostic factors for its progression, and treatment strategies.It was proven with new sensitive methods of diagnostics that surgical castration (CS) decreases serum testosterone (T) levels to < 20 ng/dL, while achieving T < 20 ng/dL improves outcomes and delays the development of CRPC. Regular assessment of the T level makes it possible to understand whether this androgen is adequately suppressed in the setting of potential progression of CRPC, given that late dosing may lead to an increase in T level. Improved imaging techniques and biomarker analysis enable early detection of disease progression. Prognostically significant risk factors for CRPC progression include Gleason score, the extent of metastatic spread, hereditary characteristics such as gene mutations affecting androgen receptor (AR) amplification or DNA repair deficiency mutations, prostate-specific antigen (PSA) kinetics, and biomarker levels. Today, treatment options for CRPC have gone beyond androgen deprivation therapy (ADT) to include therapy that blocks T-synthesis and/or suppresses its activity through various mechanisms. Future directions include therapies using new biological targets, drug combinations and personalized therapies. It is necessary to assess the possible reasons for the difference in the pharmacodynamics and pharmacokinetics of androgendeprivation drugs, to study the features of the processes of destruction of drugs under the action of endogenous enzymes and resorption in the subcutaneous or muscle depot, which may cause the resistance to therapy.The aim of improved treatment and diagnostic options for PCa is to delay its progression to CRPC and to prolong patient survival. Rethinking of the castration concept and advances in understanding the biology of disease progression make it necessary to revise diagnostic and treatment strategies. ADT is a fundamental vector of treatment, and it should be continued even if some new ways of treatment for CRPC are introduced.
Stereotactic hypofractive radiotherapy in the treatment of patients with lung cancer
Authors: Borisova T. N. , Nazarenko A. V. , Laktionov K. K. , Tkachev S. I. , Alieva S. B. , Breder V. V. , Trofimova O. P. , Glebovskaya V. V. , Fedorova A. A. , Marinov D. T. , Meshcheriakova N. A. , Ivanov S. M. , Gerasimov S. G. 
Published: January 2021

Introduction. Nowadays the stereotactic radiotherapy (SRT) of patients with clinical stage I-II lung cancer is the choice of the treatment modality for functionally inoperable patients. It shows safety and high efficiency in reaching the local control. Though there is a range of unsolved issues connected with the prediction of treatment efficiency and frequency of complications, an integration of new technologies in the planning and treatment process allows to widen the search of the predictive factors.Materials and methods. Since 2014, 42 patients (T1N0M0 – 16 patients, T2N0M0 – 26 patients) with clinical stage I-IIa lung cancer have underwent SRT. The majority of patients (38) have been recognized as functionally inoperable due to the concurrent broncho-pulmonary pathology, 4 conditionally operable patients have refused an operation. 11 patients had the primary multiple tumors in their anamneses, 3 patients had a сentral tumor. Used dose fractionation options were: 10 Gy х 5 fractions (n = 29) and 7 Gy х 8 fractions (n = 13) – BED = 100 Gy.Resuts. The median follow-up was 32 months (range 6–56 months). The 3-year local control was 94%. The isolated local recurrences were not registered. Overall 3-year survival rate was 74% (95% CI, 60–90) and a 3-year tumor-specific survival rate – 84% (95% CI, 71–98). During one-factor analysis a reliable influence on the prognosis of the fractionation regimen (р = 0,04) and, close to reliability, the initial SUVmax level influence (р = 0,07) were revealed. Grade 3 pulmonary toxicity was observed in 4 (9%) patients, one patient with a Central tumor died from pulmonary hemorrhage (grade 5 toxicity). Grade 3 chest pain was observed in 3 (7%) patients, two of them had a rib fracture.Conclusions. With modern approaches to SRT treatment planning and delivery there should be a search for additional treatment efficiency and toxicity predictors. The total dose delivery regimen and initial tumor SUVmax can be predictive efficiency factors, while the pulmonary tissue volume can be a predictive toxicity factor.
Management of acneiform rash associated with anti-EGFR monoclonal antibody treatment
Authors: Shatokhina E. A. , Kruglova L. S. , Polonskaia A. S. 
Published: January 2021

Introduction. Dermatologic adverse events (DAEs) occur in 50-90% of cases during anti-EGFR monoclonal antibody treatment. Positive correlation between the severity of acneiform rash (AR) and the effectiveness of anti-EGFR management is established. Low effectiveness of traditional treatment for AR impairs patients’ compliance, leads to dose reduction or drug discontinuation, affecting treatment results.Objective. To assess the effectiveness of traditional and proposed combined treatment for AR associated with anti-EGFR monoclonal antibody therapy.Materials and methods. 44 patients with grade I-II acneiform rash were included in a 12-week study. Patients were divided into 3 equal groups and received different treatment: group 1a – traditional therapy, group 1b – combined continuous therapy, and group 1c – combined intermittent therapy. Assessment of clinical outcomes was performed with DLQI, IGA score, and the NCI CTCAE v. 4.03.Results. The severity of AR in groups 1b and 1c improved by the end of week 1, and this trend was kept until the end of the study. The improvement was more prominent in group 1c comparing to group 1b. The severity of AR in group 1a improved by the end of week 1. During weeks 2 and 3 there was no significant change. At week 4 a deterioration of the evaluated parameters was registered, and the treatment regimen in group 1a was changed according to the treatment protocols of group 1c with rapid improvement of AR.Conclusion. Combined intermittent therapy with systemic doxycycline and topical therapy with metronidazole 1% gel and cream with hydrocortisone acetate 1% and fusidic acid 2% showed the best effectiveness and tolerability in patients with anti-EGFR monoclonal antibody-related AR.
Сonfirmatory study of the efficacy and tolerability of trifluridine/tipiracil (TAS-102) therapy in the Russian population with chemorefractory metastatic colorectal cancer
Authors: Fedyanin M. Yu. , Moiseenko F. V. , Chekini D. A. , Chubenko V. A. , Zhabina A. S. , Zagorskaya L. A. , Kramchaninov M. M. , Tjulandin S. A. , Moiseyenko V. M. 
Published: January 2021

Introduction. Trifluridine/Tipiracil (FTD/TPI) is a new chemotherapeutic drug approved in more than 60 countries for use in patients with metastatic colorectal cancer who have registered progression or intolerance to treatment with fluoropyrimidines, oxaliplatin and irinotecan, anti-VEGRand anti-EGFR-targeted agents. This study evaluated for the first time the effectiveness and tolerability of FTD/TPI therapy in the Russian patient population.Materials and methods. A confirmatory open-label single-arm non-randomized trial was conducted in 2 clinical centres in Russia. The main criteria for inclusion were: conduction of at least the 2nd line of standard systemic therapy for metastatic colon adenocarcinoma. The primary efficacy criteria were: 2-month progression-free survival; secondary – median progressionfree survival, disease control frequency, safety assessment, overall survival. Research number: NCT03274882.Results. A total of 26 patients were included in the study; the median age was 60.5 years (30 to 78); 19 (73%) women; and 4 patients with ECOG 0 and 22 – with ECOG 1. All patients were previously treated with the inclusion of oxaliplatin, irinotecan, fluoropyrimidines, 21 (81%) – bevacizumab, 6 (23%) – anti-EGFR antibodies, and 2 (7.7%) – regorafenib. The median for treatment courses was 4 (1–21), 11 (42.3%) patients were treated for 6 months or more. The two-month progression-free survival rate was 52% with a median progreesion-free survival rate of 4 months (95% CI 1.8–7.4 months). The median of total survival rate was 11 months (95% CI 5,2–16,8 months). Disease control was achieved in 60%. Neutropenia, nausea, vomiting, anemia, weakness prevailed among undesirable events associated with treatment (≥5 patients). The majority of complications were of the 1st–2nd degree. Among the undesirable events of the 3rd–4th degree, neutropenia was more common, while in 3 patients febrile neutropenia of the 3rd degree was registered.Conclusions. In the Russian population of patients with colorectal chemorefractory cancer, the drug FTD/TPI (TAS-102) shows efficacy and tolerability comparable to the RECOURSE registration study.
Representações Sociais de Mães sobre o Cuidado ao Filho com Câncer
Authors: Bomfim Eliane dos Santos , Oliveira Bruno Gonçalves de , Boery Rita Narriman Silva de Oliveira 
Published: January 2021

Objetivo: Apreender as representações sociais de mães sobre a condição de ter um filho com câncer. Método: Pesquisa qualitativa, fundamentada no referencial Teórico das Representações Sociais. Realizada em uma Unidade de Tratamento Oncológico, com 19 mães de criança com diagnóstico de câncer, através da técnica projetiva desenho-estória com Tema e a entrevista semiestruturada, em janeiro a março de 2016. Resultados: Após análise dos dados, emergiram asseguintes categorias temáticas: Impacto do câncer infantil; e processo de enfrentamentos de mães ao filho com câncer, sendo que esta última categoria se desdobrou em duas subcategorias: A espiritualidade no processo de enfrentamento da doença; e Apoio familiar e social no processo da doença. Conclusão: O estudo evidenciou que os cuidados específicos das mães expressos através da proteção, afeto e amor visam atender as necessidades ao filho com câncer. Essa experiência de cuidar traz dificuldades ocasionadas pela adaptação à nova realidade social.Descritores: Cuidado; Mãe; Criança; Câncer; Representação.
Os Profissionais de Enfermagem merecem mais que aplausos
Authors: Farias Veronica Egline , Lira Geison Vasconcelos 
Published: January 2021

Objetivo: refletir acerca dos aplausos dirigidos aos profissionais de Enfermagem na “linha de frente” do combate à COVID-19. Método: artigo de opinião a partir das reportagens na mídia a respeito dos aplausos à Enfermagem, apesar da crescente precariedade de trabalho nos serviços públicos de saúde, nos últimos anos. Resultados: evidenciou-se a disparidade entre este gesto de gratidão, a escassez de recursos e carga de trabalho exaustiva, que tem se intensificado ainda mais neste contexto. Conclusão: Para além de apoio psicológico e social, é necessário também maior investimento na Saúde, para diminuir concretamente o risco de infecção que vem sendo enfrentado pelos profissionais devido à falta de recursos apropriados para seu trabalho.Descritores: Enfermagem; Infecções por Coronavírus; COVID-19. NURSING PROFESSIONALS DESERVE MORE THAN APPLAUSEObjective: to reflect on the applause addressed to Nursing professionals on the “front line” of the fight against COVID-19. Method: opinion article based on media reports about applause for Nursing professionals, despite the growing precariousness of work in public health services in recent years. Results: the disparity between this gesture of gratitude, the scarcity of resources and an exhaustive workload became evident, which has intensified even more in this context. Conclusion: in addition to psychological and social support, greater investment in health is also needed to concretely reduce the risk of infection that professionals are facing due to the lack of appropriate resources for their work. Descriptors: Nursing; Coronavirus infections; COVID-19. PROFESIONALES DE ENFERMERÍA MERECEN MÁS QUE APLAUSOSObjetivo: reflexionar sobre los aplausos dirigidos a los profesionales de enfermería en la “primera línea” de la lucha contra COVID-19. Método: artículo de opinión desde los medios informativos sobre los aplausos para Enfermería, a pesar de la creciente precariedad del trabajo en los servicios de salud pública en los últimos años. Resultados: se hizo evidente la disparidad entre este gesto de gratitud, la escasez de recursos y una carga de trabajo exhaustiva, que se ha intensificado aún más en este contexto. Conclusión: además del apoyo psicológico y social, también se necesita una mayor inversión en Salud para reducir concretamente el riesgo de infección que enfrentan los profesionales debido a la falta de recursos apropiados para su trabajo. Descriptores: Enfermería; Infecciones por Coronavirus; COVID-19.