bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barreiras para a prática de atividades físicas entre usuários de substâncias psicoativas
Authors: Matias Guilherme Henrique de Lima , Fonseca Romulo Maia Carlos 
Published: December 2021

Objetivo: Verificar as barreiras que influenciam a não realização de atividade física no tempo livre entre usuários de substâncias psicoativas.
Método: 144 indivíduos com média de idade de 44.3±12.6 anos foram entrevistados respondendo um questionário que verifica as barreiras para a prática de atividades físicas. Foi aplicado o teste Qui-quadrado de independência aceitando um p<0.05 como significativo.
Resultados: Os dados mostraram que há associação entre as sentenças do questionário e o padrão de resposta dos indivíduos [x2(13)=193.88; p≤0.001]. Foi encontrada significância como barreira para prática de atividade física o cansaço físico, falta de companhia, falta de incentivo familiar e acometimento de dores leves ou mal-estar. Por outro lado, a falta de tempo, fator climático, não disponibilidade no ambiente, não disponibilidade de equipamento e falta de habilidade física foram apontados, significativamente, como não serem barreiras para a prática de atividade física em usuários de substâncias psicoativas.
Conclusão: A partir destes dados será possível estabelecer estratégias mais efetivas para a promoção da prática de atividade física nesta população.
Tratamiento y vuelta a la práctica deportiva en jóvenes con diagnóstico de espondilosis. Revisión sistemática
Authors: García-Sequeiros Yolanda , Taboada-Iglesias Yaiza 
Published: December 2021

Objetivo: analizar los tratamientos aplicados en pacientes menores de edad con espondilólisis y ver su relación con la vuelta al deporte.
Método: se revisaron los artículos en inglés, español o portugués publicados entre 2015 y 2020 publicados en PubMed, Medline, Cinahl, Scopus, Sport Discuss y Web Of Science, seleccionando aquellos que reflejasen el tratamiento de espondilólisis en menores de 18 años y su vuelta al deporte. Se seleccionaron 10 artículos que cumplieron con los criterios de inclusión y exclusión y fueron analizados.
Conclusión: el tratamiento conservador es la primera opción para todos los pacientes con espondilólisis, pero parece ser efectivo en las etapas tempranas y progresivas, siendo la opción ideal para las espondilólisis terminales una intervención mínimamente invasiva. Ambos tratamientos deben constar de un periodo de reposo de la actividad deportiva y una rehabilitación física progresiva antes de retomarla.
Pengaruh Latihan Body-Weight Squat Dapat Meningkatkan Kekuatan Otot Tungkai Bawah Lansia Wanita di Lingkungan Banjar Bangah Kabupaten Tabanan
Authors: Riantini Ni Putu , Pramita Indah , Yasa I made Astika 
Published: December 2021

Lansia akan mengalami perubahan pada sistem muskuloskeletal khususnya pada otot, seperti penurunan pada massa otot dan kekuatan otot. Adanya penurunan kekuatan otot pada esktremitas bawah akan menyebabkan gerakan menjadi lambat dan kaku, langkah yang menjadi pendek, dan saat berdiri tubuh tidak stabil sehingga aktivitas sehari-hari lansia mengalami hambatan. Tujuan dari penelitian ini untuk mengetahui latihan body weight squat dapat meningkatkan kekuatan otot tungkai bawah lansia wanita di Lingkungan Banjar Bangah, Kabupaten Tabanan. Populasi penelitian berjumlah 35 orang dengan sampel 11 orang yang telah didapatkan berdasarkan kriteria penelitian. Alat ukur penelitian menggunakan five times sit to stand test. Rancangan penelitian ini menggunakan metode Pre-eksperimental dengan one grup pre-test and post- test. Penelitian dilakukan selama 4 minggu. Hasil analisis deskriptif kekuatan otot tungkai bawah pre-test diperoleh nilai rata-rata 13,11 detik dan post-test nilai rata-rata 10,34 detik. Selanjutnya dilakukan dilakukan uji normalitas dengan Shapiro Wilk Test dan uji hipotesis dengan uji Paired Sampel T Test. Hasil Shapiro Wilk Test berdistribusi normal dengan nilai signifikan pre test 0,575 dan post test 0,259 serta adanya peningkatan presentase sebesar 21,12%. Hasil uji Paired Sampel T Test menunjukan nilai signifikan yaitu 0,000 yang artinya terdapat peningkatan pada kekuatan otot tungkai bawah pada lansia wanita. Berdasarkan penelitian ini dapat disimpulkan bahwa terjadinya peningkatan kekuatan otot tungkai bawah setelah diberikan latihan body weight squat pada lansia wanita.
Kata kunci : Lansia Wanita, Kekuatan Otot Tungkai Bawah, Latihan Body Weight Squat
Hubungan Gerakan Repetitif Terhadap Kejadian Carpal Tunnel Syndrome (CTS) Pada Pemetik Daun Teh Di Pt. Mitra Kerinci Kabupaten Solok Selatan Tahun 2021
Authors: Utami Rindu Febriyeni , Munawarah Siti , Khairunissa Hatifa 
Published: December 2021

ABSTRAK
Carpal Tunnel Syndrome (CTS) merupakan neuropati tekanan terhadap nervus medianus dalam terowongan karpal pada pergelangan tangan. Carpal Tunnel Syndrome (CTS) dipengaruhi oleh beberapa faktor, yaitu gerakan repetitif. Penelitian ini bertujuan untuk mengetahui hubungan gerakan repetitif terhadap kejadian Carpal Tunnel Syndrome (CTS) pada pemetik daun teh di PT. Mitra Kerinci Kabupaten Solok Selatan Tahun 2021.Desain penelitian ini adalah kuantitatif dengan study cross sectional. Tekhnik pengambilan sampel menggunakan metode accedental sampling. Penelitian ini dilakukan pada bulan Agustus 2021 terhadap 40 orang pekerja pemetik daun teh di PT. Mitra Kerinci Kabupaten Solok Selatan Tahun 2021.Hasil uji statistik chi-square didapatkan angka kejadian Carpal Tunnel Syndrome (CTS) pada pemetik daun teh adalah 31 orang (77,5%), dan gerakan repetitif yang beresiko sebanyak 33 orang (82,5%). Nilai signifikan kejadian Carpal Tunnel Syndrome (CTS) dengan gerakan repetitif didapatkan p=0,000.Disimpulkan terdapat hubungan gerakan repetitif terhadap kejadian Carpal Tunnel Syndrome (CTS) pada pemetik daun teh di PT. Mitra Kerinci Kabupaten Solok Selatan Tahun 2021.

Kata kunci : Gerakan Repetitif, Carpal Tunnel Syndrome (CTS)
EVALUASI KEBIJAKAN PUBLIK TENTANG PROGRAM PENGEMBANGAN PARIWISATA KABUPATEN LAMPUNG TIMUR
Authors: Alvionita Vivi , Darmastuti Ari , K Robi Cahyadi , Makhya Syarief 
Published: December 2021

Kabupaten Lampung Timur menjadi salah satu daerah di Provinsi Lampung yang melakukan pembangunan di bidang pariwisata dengan menyelenggarakan 101 event dan festival wisata pada tahun 2018. Penyelenggaraan kalender wisata ini merupakan penyelenggaran kalender wisata tebanyak di Provinsi Lampung pada tahun 2018 dan berdampak salah satunya pada peningkatan jumlah wisatawan dan uang berputar. Oleh sebabnya evaluasi program pariwisata ini menjadi hal yang menarik untuk diteliti. Penelitian ini bertujuan untuk melihat bagaimana evaluasi program pengembangan pariwisata Kabupaten Lampung Timur dengan melakukan evaluasi terhadap program yang ditinjau dari 4 aspek yaitu masukan, proses, manfaat dan akibat. Penelitian ini menggunakan metode kombinasi dengan pendekatan kuantitatif deskriptif sebagai pendekatan primer dan kualitatif sebagai pendekatan sekunder dengan metode wawancara. Hasil penelitian menunjukkan bahwa, dari pengembangan program ini mampu meningkatkan jumlah wisatawan yang cukup signifikan, meningkatkan PDRB, meningkatkan jumlah objek wisata, terbukanya lapangan usaha, perlahan merubah citra buruk Kabupaten Lampung Timur, sarana edukasi masyarakat dalam berbahasa asing serta memacu masyarakat untuk meningkatkan keamanan daerahnya. Peneliti juga menemukan beberapa kekurangan dari program ini yaitu, terbatasnya anggaran dan belum maksimalnya sarana dan prasarana, belum adanya kontribusi langsung terhadap PAD, belum adanya kerjasama antar industri wisata, masih kurangnya kualitas dan inovasi event dan festival yang terselenggara.
Kata kunci: Evaluasi, Program Pariwisata
IMPLEMENTASI PROGRAM DANA BANTUAN OPERASIONAL SEKOLAH (BOS) TINGKAT PENDIDIKAN DASAR PADA MASA PANDEMI COVID-19 DI KABUPATEN BANDUNG PROVINSI JAWA BARAT
Authors: Madjid Udaya , Nurrahman Agung , Wahyuni Nurul 
Published: December 2021

Dana Bantuan Operasional Sekolah merupakan upaya pemerintah dalam meningkatkan pencapain Program Wajib Belajar, hal ini tidak terlepas dari keadaan di masa pandemi saat ini. Kementrian Pendidikan dan Kebudayaan Republik Indonesia mengeluarkan sebuah edaran terkait dengan penggunaan dana Bantuan Operasional Sekolah di masa pandemi, pada edaran tersebut terdapat beberapa perubahan kebijakan pengalokasian dana dan penekanan alokasi terkait dengan pencegahan penularan Covid-19. Tujuan penelitian adalah untuk memperoleh gambaran umum dan mendeksripsikan implementasi penyaluran dana Bantuan Operasional Sekolah di Kabupaten Bandung pada masa pandemi Covid-19. Metode yang digunakan adalah metode penelitian kualitatif deskriptif dengan teknik pengumpulan data berupa observasi, wawancara dan dokumentasi sedangkan dalam menganalisis data penulis menggunakan tiga alur kegiatan yaitu reduksi data, penyajian data, dan penarikan kesimpulan. Temuan penelitian ini adalah masih terdapat pihak sekolah yang tidak mengikuti kegiatan sosialisasi sehingga berimplikasi pada kurang maksimalnya sosialisasi yang dilaksanakan karena sosialisasi menjadi kurang tepat sasaran. Kesimpulan yang penulis ambil bahwa pelaksanaan penyaluran BOS di Kabupaten belum maksimal hal ini dikarenakan masih terdapat indikator-indikator yang belum terpenuhi dalam pelaksanaanya terutama yang terdapat pada dimensi komunikasi dan sumber daya. Oleh karena itu penulis menyarankan kepada Pemerintah Daerah untuk meningkatkan kemampuan pihak sekolah dalam pengelolaan Dana BOS melalui perbaikan sarana dan prasarana, sosialisasi, pelatihan maupun pengangkatan pegawai yang memiliki basic dalam pengelolaan keuangan.
Kata Kunci: Implementasi, Dana Bantuan Operasional Sekolah, Pendidikan Dasar
Robust Agrobacterium-Mediated Transient Expression in Two Duckweed Species (Lemnaceae) Directed by Non-replicating, Replicating, and Cell-to-Cell Spreading Vectors
Authors: Peterson Anton , Kishchenko Olena , Zhou Yuzhen , Vasylenko Maksym , Giritch Anatoli , Sun Jian , Borisjuk Nikolai , Kuchuk Mykola 
Published: December 2021

Plant-based transient expression systems have recognized potential for use as rapid and cost-effective alternatives to expression systems based on bacteria, yeast, insect, or mammalian cells. The free-floating aquatic plants of the Lemnaceae family (duckweed) have compact architecture and can be vegetatively propagated on low-cost nutrient solutions in aseptic conditions. These features provide an economically feasible opportunity for duckweed-based production of high-value products via transient expression of recombinant products in fully contained, controlled, aseptic and bio-safe conditions in accordance with the requirements for pharmaceutical manufacturing and environmental biosafety. Here, we demonstrated Agrobacterium-mediated high-yield transient expression of a reporter green fluorescent protein using deconstructed vectors based on potato virus X and sweet potato leaf curl virus, as well as conventional binary vectors, in two representatives of the Lemnaceae (Spirodela polyrhiza and Landoltia punctata). Aseptically cultivated duckweed populations yielded reporter protein accumulation of &gt;1 mg/g fresh biomass, when the protein was expressed from a deconstructed potato virus X-based vector, which is capable of replication and cell-to-cell movement of the replicons in duckweed. The expression efficiency demonstrated here places duckweed among the most efficient host organisms for plant-based transient expression systems, with the additional benefits of easy scale-up and full containment.
A Review of Prognosis Model Associated With Cardiogenic Shock After Acute Myocardial Infarction
Authors: Wang Jingyue , Shen Botao , Feng Xiaoxing , Zhang Zhiyu , Liu Junqian , Wang Yushi 
Published: December 2021

Objective: Cardiogenic shock seriously affects the survival rate of patients. However, few prognostic models are concerned with the score of cardiogenic shock, and few clinical studies have validated it. In order to optimize the diagnosis and treatment of myocardial infarction complicated with cardiogenic shock and facilitate the classification of clinical trials, the prognosis score model is urgently needed.Methods: Cardiogenic shock, severe case, prognosis score, myocardial infarction and external verification were used as the search terms to search PubMed, Embase, Web of Science, Cochrane, EBSCO (Medline), Scopus, BMC, NCBI, Oxford Academy, Science Direct, and other databases for pertinent studies published up until 1 August 2021. There are no restrictions on publication status and start date. Filter headlines and abstracts to find articles that may be relevant. The list of references for major studies was reviewed to obtain more references.Results and Conclusions: The existing related models are in urgent need of more external clinical verifications. In the meanwhile, with the development of molecular omics and the clinical need for optimal treatment of CS, it is urgent to establish a prognosis model with higher differentiation and coincidence rates.
Biofuel Discount Rates and Stochastic Techno-Economic Analysis for a Prospective Pennycress (Thlaspi arvense L.) Sustainable Aviation Fuel Supply Chain
Authors: Trejo-Pech Carlos Omar , Larson James A. , English Burton C. , Yu T. Edward 
Published: December 2021

The international aviation industry has the goal to gradually reduce carbon emissions mainly by using sustainable aviation fuel (SAF). However, currently SAF cannot be produced at competitive prices relative to petroleum-based jet fuel. Pennycress is a crop whose oilseed could be used as a relatively low-cost feedstock to produce SAF, potentially benefiting farmers and the environment. This stochastic techno-economic analysis (TEA) studies an enterprise buying pennycress oilseed from farmers, extracting the bio-oil and selling it to a biorefinery that converts bio-oil into SAF. Maximum buying prices (MBP)—prices that yield a zero net present value—the crushing enterprise could pay farmers for pennycress oilseed are estimated. To conduct the analysis, discount rates are estimated based on financial data of biofuel firms, thus providing a realistic benchmark to evaluate profitability and feedstock buying prices. Estimated risk-adjusted discount rates vary between 12 and 17%, above rates typically used in similar valuations. Estimated stochastic MBP range between 10.18 and 11.73 ¢ pound−1, which is below the price at which farmers are willing to plant pennycress, according to recent research. By considering the crushing facility’s inherent cash flow structure and risk, the distributions of stochastic modified internal rate of return suggest the crushing enterprise could be economically attractive at a 14% discount rate, our most likely estimate. However, between 11 and 17% times the cash flow model is simulated, the firm falls under financial distress. Overall, the findings suggest potential barriers for deployment of a SAF supply chain without governmental incentives or related policies.
Common Effluent Treatment Plants Monitoring and Process Augmentation Options to Conform Non-potable Reuse
Authors: Ali Muntjeer , Almohana Abdulaziz Ibrahim , Alali Abdulrhman Fahmi , Kamal Mohab Amin , Khursheed Abbas , Khursheed Anwar , Kazmi A. A. 
Published: December 2021

The stringency in effluent discharge and reuse standards has made it extremely expensive to discharge the effluents safely or reuse them. Therefore, existing wastewater treatment plants should be evaluated and improved or augmented. With this aim, five existing common effluent treatment plants (CETPs) in North India were evaluated, including: the State infrastructure Development Corporation Uttrakhand Limited (SIDCUL) Haridwar, which processes 4.5 Million Liters per day (MLD); the Industrial Model Township (IMT) Manesar Gurgaon, 55 MLD (comprising two streams of 25 and 30 MLD each); the Lawrence Road Industrial Area (LRIA), Delhi, 12MLD (12MLD LRIA); Mayapuri Industrial Area (MIA), Delhi, 12MLD; and the Integrated Industrial Estate (IIE) SIDCUL Pantnagar, 4.0 MLD. These plants were designed to produce treated effluent for non-potable reuse. Results showed that the integrated efficiency (IEa) of all CETPs was 10–20% larger than standard integrated efficiency (IEs), indicating the suitability of the technology, except for 12MLD at MIA CETP where the IEa was 20% lower than IEs, due to the absence of any biological unit in the process. Combined post-treatment of secondary effluent by coagulation, Ultrafiltration (UF), followed by ozonation for CETP SIDCUL Haridwar, was also conducted for its non-potable water reuse. This process was able to reduce Biochemical Oxygen Demand (BOD) by 77%, Chemical Oxygen Demand (COD) by 76%, turbidity by 96%, and Total Suspended Solids (TSS) by 100%. All these parameters confirmed the effluent standards for non-potable reuse. The color was reduced to 4.0 from 42.0 Pt-Co units by the exposure ozone concentration of 8.3 mg/L for up to 4.0 min on the treated water from SIDCUL CETP, which reduced the color by 90% and complied with reuse standards. Hence Combined post treatment by coagulation, UF followed Ozonation of secondary treated effluent could be a better option for the potable reuse of treated water in various domestic and industrial applications.
Screening and Functional Analysis of TEK Mutations in Chinese Children With Primary Congenital Glaucoma
Authors: Qiao Yunsheng , Chen Yuhong , Tan Chen , Sun Xinghuai , Chen Xueli , Chen Junyi 
Published: December 2021

Purposes: Recent studies have suggested that loss-of-function mutations of the tunica intima endothelial receptor tyrosine kinase (TEK) are responsible for approximately 5% of primary congenital glaucoma (PCG) cases in diverse populations. However, the causative role of TEK mutations has not been studied in Chinese PCG patients. Here, we report the mutation spectrum of TEK after screening a large cohort of PCG patients of Chinese Han origin and analyze the identified variants in functional assays.Methods: TEK-targeted next-generation sequencing (NGS) was performed in 200 PCG patients. Candidate variants were prioritized by mutation type and allele frequency in public datasets. Plasmids containing wild type and identified variants of TEK were constructed and used to assess protein expression, solubility, receptor auto-phosphorylation, and response to ligand stimulation in cell-based assays.Results: Ten missense and one nonsense heterozygous variants were detected by NGS in 11 families. The clinical features of TEK variants carriers were comparable to that of TEK-mutated patients identified in other populations and CYP1B1-mutated individuals from in-house database. Functional analysis confirmed four variants involving evolutionarily conserved residues to be loss-of-function, while one variant (p.R1003H) located in tyrosine kinase domain seemed to be an activating mutation. However, our results did not support the pathogenicity of the other five variants (p.H52R, p.M131I, p.M228V, p.H494Y, and p.L888P).Conclusion: We provide evidence for TEK variants to be causative in Chinese PCG patients for the first time. Attention needs to be paid to TEK mutations in future genetic testing.
Global Public Interest and Seasonal Variations in Alzheimer's Disease: Evidence From Google Trends
Authors: Mao Yan-Mei , Wang Peng , Wang Xiao-Yu , Ye Dong-Qing 
Published: December 2021

Background: As the world's population ages, Alzheimer's disease (AD), a common neurodegenerative disease, is a major challenge to human health in the future. Understanding the information needs on AD of the global public can contribute to the prevention and control of AD. The purpose of this study was to explore global public interest and seasonal variations in AD using Google Trends (GT).Methods: GT was used to obtain relative search volume (RSV) of the keyword “Alzheimer's disease” in six English-speaking countries (Australia, New Zealand, the USA, the UK, Canada, and Ireland) and the world from January 2004 to December 2020. Cosinor analysis was applied to detect the seasonality of AD-related RSV. Time series plot was used to observe the trend of annual mean AD-related RSV. Globally, hot topics and top rising topics related to AD were also analyzed. In addition, we also explored the geographical distribution characteristics of AD-related RSV.Results: AD-related RSV declined steadily from January 2004 to December 2013 and rose steadily from January 2014 to December 2020. Search popularity of AD is low in the southern hemisphere, compared to the northern hemisphere. Cosinor analysis showed that there were significant seasonal variations in AD-related RSV in six English-speaking countries (all P &lt; 0.05). Interestingly, regardless of the hemisphere, peaks were observed in the winter months and trough in the summer months. Topics related to the characteristics and etiology of AD, early onset AD, AD-related associations, care of AD patients, and diseases that can easily be confused with AD had received special attention.Conclusions: There is increasing global public interest for AD and a significant seasonal variation in AD. A better understanding of the seasonal variations and public interest of AD by governments, health workers and patients can contribute to the prevention, management, and treatment of AD.
Association Between Epilepsy and Leigh Syndrome With MT-ND3 Mutation, Particularly the m.10191T>C Point Mutation
Authors: Na Ji-Hoon , Lee Min Jung , Lee Chul Ho , Lee Young-Mock 
Published: December 2021

Background and Purpose: Recent advances in molecular genetic testing have led to a rapid increase in the understanding of the genetics of Leigh syndrome. Several studies have suggested that Leigh syndrome with MT-ND3 mutation is strongly associated with epilepsy. This study focused on the epilepsy-related characteristics of Leigh syndrome with MT-ND3 mutation identified in a single tertiary hospital in South Korea.Methods: We selected 31 patients with mitochondrial DNA (mtDNA) mutations who were genetically diagnosed with mtDNA-associated Leigh syndrome. Among them, seven patients with MT-ND3 mutations were detected. We reviewed various clinical findings such as laboratory findings, brain images, electroencephalography data, seizure types, seizure frequency, antiepileptic drug use history, and current seizure status.Results: The nucleotide changes in the seven patients with the Leigh syndrome with MT-ND3 mutation were divided into two groups: m.10191T&gt;C and m.10158T&gt;C. Six of the seven patients were found to have the m.10191T&gt;C mutations. The median value of the mutant load was 82.5%, ranging from 57.9 to 93.6%. No particular tendency was observed for the first symptom or seizure onset or mutant load. The six patients with the m.10191T&gt;C mutation were diagnosed with epilepsy. Three of these patients were diagnosed with Lennox–Gastaut syndrome (LGS).Conclusion: We reported a very strong association between epilepsy and MT-ND3 mutation in Leigh syndrome, particularly the m.10191T&gt;C mutation. The possibility of an association between the epilepsy phenotype of the m.10191T&gt;C mutation and LGS was noted.