bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimentation or projectification of urban change? A critical appraisal and three steps forward
Authors: Torrens Jonas , von Wirth Timo 
Published: September 2021

AbstractUrban experimentation has proliferated in recent years as a response to sustainability challenges and renewed pressures on urban governance. In many European cities, diverse and rapidly changing experimental forms (e.g. urban living laboratories, pilots, trials, experimental districts) are becoming commonplace, addressing ambitious goals for smartness, circularity, and liveability. Academically, there is a growing concern for moving beyond the focus on individual experiments and the insistence on upscaling their primary transformation mechanism. However, the phenomena of ‘projectification’ – whereby project-based forms of organising have become ubiquitous, shaping expectations about experimentation – is increasingly perceived as a barrier. Nevertheless, how specifically experimentation and projectification intersect remains unclear. Our theoretical perspective examines how the widespread tendency towards projectification shapes urban experimentation and the potential implications for urban transformations. It problematises the current wave of experimentation and how it contributes to the projectification of urban change processes. We present three steps to redress this issue and indicate directions for future research.
Surgical management of cellular congenital mesoblastic nephroma in a neonate: a case report and review of literature
Authors: Ihab Ali , Abdullah Al Otaibi , Abdullah Abduldaem , Mohammad Alonazi , Maha Nojoom 
Published: September 2021

Abstract
Background
Congenital mesoblastic nephroma (CMN) is the most common type of renal stromal tumor in neonates. It is classified into cellular, classical, and mixed types. The multidisciplinary management approach is the mainstay of management. We are reporting a case of neonatal congenital mesoblastic nephroma in a full-term boy with intrauterine growth restriction and hypertension managed effectively in our institution.

Case presentation
A full-term boy with intrauterine growth restriction (IUGR) with a birth weight of 2.3 kg, referred at birth with an abdominal mass. His antenatal scan at 35 weeks showed a cystic abdominal mass. On delivery, a huge visible abdominal mass of cystic consistency and smooth surface was noticed at the right side of the abdomen. blood pressure was 98/75 mmHg. It was responsive to hydralazine. Aldosterone and renin were significantly elevated at more than 100 and 500 ng/dl, respectively. Serum neurone-specific enolase (NSE) was 35 ng/ml while alfa feto protein was (AFP) 50,000 kIU/L. An abdominal ultrasound scan revealed an ill-defined large heterogeneous mass of 6.09 × 6.5 × 5.77 cm that arises from the right kidney. A computed tomography scan confirmed a right kidney mass with peripheral claw sign of the normal right renal tissue. It was crossing the midline and causing a mass effect on the adjacent structures. The right renal artery and vein were compressed and shifted posteriorly and inferomedially. Right radical nephrectomy was performed via a right lower transverse incision. The tumor was completely excised with a tumor weight of 270 g and a size of 10.5 × 8 × 5.5 cm. Histopathological diagnosis was mesoblastic nephroma of a cellular type which was confirmed by immunohistochemistry. Post-operatively, the blood pressure has significantly reduced and antihypertensive medications were eventually weaned off. The multidisciplinary team decided to preserve chemotherapy only in case of recurrence. At 3 months follow-up, no features of recurrence were noticed based on surveillance ultrasonography.

Conclusion
Mesoblastic nephroma should be considered in any newborn with renal mass. The multidisciplinary team approach with aggressive management of hypertension, detailed radiological investigation, and complete tumor resection is fundamental for obtaining an excellent outcome for such entities.
Patients' Expectations of Benefits From Large-Panel Genomic Tumor Testing in Rural Community Oncology Practices
Authors: Anderson Eric C. , DiPalazzo John , Edelman Emily , Helbig Petra , Reed Kate , Miesfeldt Susan , Thomas Christian , Lucas F. Lee , Fenton Anny T. H. R. , Antov Andrey , Hall Michael J. , Roberts J. Scott , Rueter Jens , Han Paul K. J. ,   MCGI Working Group
Published: September 2021

PURPOSE Large-panel genomic tumor testing (GTT) is an emerging technology that promises to make cancer treatment more precise. Because GTT is novel and complex, patients may have unrealistic expectations and limited knowledge of its benefits. These problems may limit the clinical value of GTT, but their prevalence and associated factors have not been explored. METHODS Patients with cancer enrolled in a large initiative to disseminate GTT in community oncology practices completed surveys assessing their expectations, knowledge, and attitudes about GTT. The study sample (N = 1,139) consisted of patients with a range of cancer types (22% gynecologic, 14% lung, 10% colon, 10% breast, and 46% other malignancies) and cancer stages (4% stage I, 3% stage II, 15% stage III, and 74% stage IV). Mean age was 64 years (standard deviation = 11); 668 (59%) were women; 71% had no college degree; 57% came from households with less than $50,000 US dollars household income; and 73% lived in a rural area. RESULTS Generally, patients had high expectations that they would benefit from GTT (M = 2.81 on 0-4 scale) and positive attitudes toward it (M = 2.98 on 0-4 scale). Patients also had relatively poor knowledge about GTT (48% correct answers on an objective test of GTT knowledge). Greater expectations for GTT were associated with lower knowledge (b = –0.46; P < .001), more positive attitudes (b = 0.40; P < .001), and lower education (b = –0.53; P < .001). CONCLUSION This research suggests patients have high expectations that they will benefit from GTT, which is associated with low knowledge, positive attitudes, and low education. More research is needed to understand the concordance between expectations and actual clinical outcomes.
Characterization of the Binding of Adenosine-5′-monophosphate to a µ-Type Alkoxide-Linked Dinuclear Zinc(II) Complex in Crystal and Solution State
Authors: Kinoshita-Kikuta Emiko , Ichimaru Yoshimi , Yamano Yoshi , Kato Koichi , Kurosaki Hiromasa , Kinoshita Eiji , Koike Tohru 
Published: September 2021

Abstract
The binding of adenosine-5′-monophosphate dianion (AMP2−) to a µ-type alkoxide-linked dinuclear zinc(II) complex (Zn2L3+) has been studied {L = alkoxide form of 1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-ol}. X-ray crystallography and potentiometric pH titration have been used to decipher the structure of 1:1 AMP2−-bound Zn2L3+ complex in crystal and solution state. The crystal analysis of the AMP2−–Zn2L3+ complex demonstrated that the 5′-phosphomonoester dianion binds to the two zinc(II) ions in a µ-η2 bridge coordination mode. Each zinc(II) ion has a distorted trigonal-bipyramidal coordination environment with five donor atoms: two pyridine N, alkoxide O−, tertiary amine N, and phosphate O−. In contrast, 1:1 NO3−-bound Zn2L3+ complex showed that the nitrate anion binds to one of the zinc(II) ions in a monodentate coordination mode and a water molecule coordinates to the other zinc(II) ion. The pH titration study disclosed that the AMP2−–Zn2L3+ complex is remarkably stable in a wide pH range between 5 and 9. The dissociation constant Kd (= [AMP2−][Zn2L3+]/[AMP2−–Zn2L3+]) is an extremely low value of 4.0 nM at 25 °C and I = 0.10 M (NaNO3) in aqueous solution.
Design and prototype of TOMO: an app for improving drug resistant TB treatment adherence
Authors: Fuad Anis , Herwanto Guntur Budi , Pertiwi Ariani Arista Putri , Wahyuningtias Siska Dian , Harsini Harsini , Maula Ahmad Watsiq , Putri Diyah Utami Kusumaning , Probandari Ari , Ahmad Riris Andono 
Published: September 2021

Background: Drug resistance and multi drugs tuberculosis (DR/MDR-TB) are associated with patients' low adherence to undergoing complex treatment. Driven by the increasing use and penetration of a smartphone and the End of TB Strategy that seeks for digital health solution, Center for Tropical Medicine Universitas Gadjah Mada has developed TOMO, an Android-based app for improving medication adherence in MDR-TB. Objective: This paper aims to present the sequential steps to develop the app, its general architecture, and its functionalities. Methods: It is a design thinking process involving two MDR-TB referral centers, district health offices, primary health centers, and MDR-TB patients in Central Java and Yogyakarta, Indonesia. We adopted the Principles for Digital Development to develop and design the app. MDR-TB treatment guideline from the Indonesian Ministry of Health was used to develop functionalities of the app for improving adherence. Results: TOMO app could be used by patients, primary health centers, clinical teams, and case managers. The app prototype features include adverse event records and reports, medication-taking reminders, and communication between the patient and the TB-MDR case manager. We have successfully tested the functionalities based on four use cases: patients with high adherence, patients with low adherence, patients with adverse events, and patients following treatment in the primary health center without any visit to the MDR-TB center. Conclusion: TOMO app has contributed to the limited body of literature on improving TB-MDR adherence with digital health intervention, especially using a health app. The app has been tested using four scenarios. We will follow up with usability testing before implementing the app in a real setting.
COVID-19: Identifying countries with indicators of success in responding to the outbreak
Authors: Kennedy David S. , Vu VK , Ritchie Hannah , Bartlein Rebecca , Rothschild Oliver , Bausch Daniel G. , Roser Max , Seale Anna C. 
Published: September 2021

Background: In designing responses to the COVID-19 pandemic, it is critical to understand what has already worked well. We aimed to identify countries with emerging success stories from whom policymakers might draw important lessons. Methods: We developed a process to first include countries with large enough populations that results were unlikely to be due to chance, that had sufficient cases for response mechanisms to be tested, and that shared the necessary publicly available data. Within these countries, we looked at indicators suggesting success in terms of detecting disease, containing the outbreak, and treating those who were unwell. To support comparability, we measured indicators per capita (per million) and across time. We then used the indicators to identify three countries with emerging success stories to include some diversity in global region, population demographics and form of government. Results: We identified 66 countries that met our inclusion criteria on 18th May 2020. Several of these countries had indicators of success against the set indicators at different times in the outbreak. Vietnam had high levels of testing and successful containment with no deaths reported. South Korea had high levels of testing early in the outbreak, supporting containment. Germany had high levels of sustained testing and slower increases in cases and deaths than seen in other comparable settings. Conclusions: At the time of our assessment, Vietnam and South Korea were able to contain the outbreak of COVID-19 and avoid the exponential growth in cases seen elsewhere. Germany had more cases and deaths, but was nevertheless able to contain and mitigate the outbreak. Despite the many limitations to the data currently available, looking at comparative data can help identify countries from whom we can draw lessons, so that countries can inform and adapt their strategies for success in response to COVID-19.
ВЛИЯНИЕ ПОГОДНЫХ УСЛОВИЙ НА УРОЖАЙНОСТЬ ЯРОВОГО ЯЧМЕНЯ В ЗОНЕ ВЛИЯНИЯ ЛЕСНОЙ ПОЛОСЫ
Authors: Seminchenko Elena V. 
Published: September 2021

Обоснование. В статье изложены материалы исследований по влиянию полезащитных лесных полос на рост и развитие ярового ячменя. Объектом исследований является яровой ячмень сорта Медикум 139. Исследования проводились в Землепользовании «Городищенское», кадастровый номер 34:03:000000:6.
Цель работы – обосновать роль осадков и других факторов для формирования урожая ярового ячменя под влиянием лесной полосы.
Материалы и методы. Учет урожайности определялся на площадках 1 м2 на удалении соответственно 5, 10, 30Н. Контролем служил открытый участок без лесной полосы. Снопы отбирали в трехкратной повторности, замет обмолачивали. Полученное зерно взвешивали и проводили пересчет урожайности на 1 га. Урожай зерна, полученный при взвешивании, приводился к 14%-й влажности и 100%-й частоте. Длина стебля, количество колосков и зерен в колосе определялись визуально. Масса 1000 зерен определялась на технико-химических весах.
Результаты. Анализ данных показал, что запасы продуктивной влаги на межполосной клетке распределены неравномерно. В условиях агролесоландшафта наибольший весенний влагозапас накапливается в зоне от 5Н до 15Н от полезащитных лесных полос. Исследования показали, низкий ГТК приходится на летний период (июль-август) практически во все годы исследований. Обеспеченным по продуктивности накоплению осадков был 2016 год, где ГТК составил 0,7, в остальные годы засушливый 0,3-0,5. Структурный анализ ярового ячменя показал, что наибольшая урожайность была на расстоянии 10Н и состалила у ярового ячменя – 1,4 т/га. В статье приведены результаты корреляционно-регрессивного анализа полученных данных по взаимосвязи урожая ярового ячменя с составляющими факторами (осадки, запасы почвенной влаги), влияющими на урожайность ярового ячменя за 2016–2020 годы. Получены результаты, приведенные в графической корреляции, и обоснована закономерность.
Заключение. Результаты исследования свидетельствуют о важной роли лесных полос. Областью применения рекомендаций является зона почв Нижнего Поволжья.
ПСИХОЛОГИЧЕСКОЕ ЗДОРОВЬЕ СПОРТСМЕНОВ В ПЕРИОД ПАНДЕМИИ COVID-2019
Authors: Kislyakov Pavel A. , Belov Mikhail S. , Konstantinova Nataliya P. 
Published: September 2021

Обоснование. Массовая самоизоляция в период пандемии COVID-19 оказала существенное влияние на спортивную деятельность, и как следствие, на психологическое здоровье спортсменов. Основные последствия для психологического здоровья спортсменов связаны в первую очередь с психосоматическими и психоэмоциональными расстройствами.
Цель исследования состояла в выявлении особенностей психологического здоровья спортсменов в период пандемии COVID-2019.
Материалы и методы. Выборку составили 419 спортсменов в возрасте от 18 до 30 лет, проживающих в различных регионах России. Исследование проводилось с использованием специально разработанной анкеты, включающей вопросы об особенностях организации тренировочного процесса в период пандемии, о дальнейших спортивных планах, о психосоматических и психоэмоциональных особенностях, вызванных вследствие отмены спортивных тренировок и соревнований. Также использовалась стандартизированная методика «Самочувствие, активность, настроение – САН» (В.А. Доскин, Н.А. Лаврентьева, В.Б. Шарай и М.П. Мирошников).
Результаты. Проведенное исследование выявило закономерность, состоящую в том, что поддержка оптимальной физической формы в период пандемии COVID-19 позволяет предупреждать негативные психосоматические и психоэмоциональные проявления, обеспечивая субъективное ощущение благоприятного физиологического и психологического состояния. Адаптивный копинг принятия спортсменами ситуации и самоконтроля прямо коррелирует с поддержкой оптимальной физической формы в период пандемии COVID-19 и, как следствие, с позитивными спортивными планами.
Заключение. Полученные результаты подтверждают, что поддержание регулярной физической активности является важной профилактической стратегией для физического и психологического здоровья во время вынужденной самоизоляции.
Varieties of the state of exchange of nitrogenous metabolites (creatinine, urea, uric acid and bilirubin) and their immune accompaniment at rats
Authors: Kuchma Igor , Flyunt Igor-Severyn , Ruzhylo Sofiya , Zukow Walery , Bilas Volodymyra , Popovych Igor 
Published: September 2021

Background. Earlier we found that even in intact rats, certain parameters of nitrogenous metabolism and immunity fluctuate in a fairly wide range, which further expands in cases of prolonged water loads. The links between the individual parameters of metabolism and immunity were revealed. Based on this, the aim of this study was to create groups that are homogeneous in the parameters of nitrogenous metabolism, followed by a search for the characteristic parameters of immunity. Material and methods. Experiment was performed on 60 healthy female Wistar rats, both intact and loaded with different mineral waters. The plasma levels and urinary excretion of the nitrogenous metabolites (creatinine, urea, uric acid and bilirubin) were determined. Immune status was assessed by thymocytogram, splenocytogram, blood leukocytogram and immunocytogram, as well as by phagocytosis parameters of blood neutrophils and monocytes. Results. The characteristic features of the members of the most numerous (29 animals) of the first cluster are moderately elevated plasma urea and upper borderline creatinineemia in combination with lower borderline uricemia. In members of the third cluster (22 animals), all seven parameters are in the range of normal. In contrast, rats of the second cluster (n=9) were found to have significantly increased levels of urea and creatinine excretion, as well as uricemia. Each cluster is accompanied by a specific constellation of immune parameters. The overall accuracy of the classification is 95%. Conclusion. The variety of states of exchange of nitrogenous metabolites is accompanied by specific constellations of immune parameters.
In-hospital rehabilitation in the treatment of multiple myeloma
Authors: Mińko Alicja , Szczypiór-Piasecka Karina , Kotrych Daniel 
Published: September 2021

Wprowadzenie: Szpiczak mnogi (MM) jest jednym z najczęstszych złośliwych nowotworów kości. Podstawową procedurą leczenia szpiczaka mnogiego jest chemioterapia połączona z autologicznym przeszczepem komórek macierzystych. Leczenie operacyjne, polegające na wycięciu guza, jest wskazane, gdy istnieje ryzyko patologicznego złamania kości lub ucisku guza na korzenie nerwowe. Konieczne jest stworzenie indywidualnego planu leczenia we współpracy interdyscyplinarnej. Ważnym elementem leczenia jest pomoc w zakresie rehabilitacji. Celem pracy było wskazanie procedur rehabilitacyjnych w leczeniu szpiczaka mnogiego po rekonstrukcji endoprotezy w okresie szpitalnym.Materials and methods: The work was written based on the medical history of a patient diagnosed with multiple myeloma in the proximal part of the right femur. The entire treatment procedure was carried out at the Department of Orthopedics, Traumatology and Oncology of the Musculoskeletal System, located at Unii Lubelskiej 1 in Szczecin.Results: Rehabilitation in the treatment process of patients after resection of the tumor in the proximal part of the femur and arthroplasty is implemented as early as 1 day after the surgery in order to activate the patient as soon as possible. The rehabilitation program was as individualized as possible to the patient and included modern techniques such as osteopathy and manulana therapy.Wniosek: Rehabilitacja jest nieodzownym elementem leczenia chorych na nowotwory. Wprowadzenie do rehabilitacji nowoczesnych technik wpływa pozytywnie na skuteczność terapii. Wczesne rozpoczęcie rehabilitacji przynosi wymierne korzyści w trakcie leczenia i powrót pacjenta do aktywnego udziału w życiu społecznym.
Neurological manifestations and complications of COVID-19. A literature review
Authors: Krasa Aleksandra Maria , Kozioł Magdalena , Piecewicz-Szczęsna Halina , Łopuszyńska Anna , Piekarska Ewa , Więsyk Piotr , Pawlicki Mateusz 
Published: September 2021

Introduction. The first case of SARS-CoV-2 infection was identified in December 2019 in Wuhan, China. The disease spread rapidly worldwide and the WHO declared a pandemic on March 11, 2020. Although coronavirus disease 2019 (COVID-19) has been associated primarily with respiratory disorders, more and more research is focusing on neurological manifestations and complications.Objective. The aim of the review is to systematize and update the knowledge and available research on neurological complications among COVID-19 patients.Review methods. A systematic search of PubMed and Google Scholar databases was conducted for studies. The following keywords combinations were used: COVID-19, SARS-CoV-2 infection, neurological complications, neurological manifestations, neuroinvasion, neurovirulence.Results. The disease in most patients is characterized by mild to medium fever, fatigue, dry cough, dyspnea, muscle pain and headache. ACE2, which is the receptor for SARS-COV-2, is ubiquitously expressed in a variety of human organs, including the brain. Following previous reports, these receptors are expressed in both glial cells and neurons. Many studies have reported neurological symptoms and complications among COVID-19 patients. The reported manifestations include: smell and taste disturbance, non-specific symptoms such as myalgia, headache and dizziness, acute cerebrovascular complications, encephalopathy, meningoencephalitis/encephalitis, seizure and complications of the peripheral nervous system.Conclusion. Healthcare professionals dealing with COVID-19, neuroscientists, and the general public should be aware of the neurological complications of COVID-19. Further studies are needed to assess the incidence of COVID-19 neurological complications in different populations and more analyzes are also required to understand the detailed mechanism of how the virus affects the nervous system.
Upper respiratory tract infection in children – immunostimulating treatment
Authors: Kaczmarczyk Dariusz , Zagacki Dawid , Morawiec-Sztandera Alina 
Published: September 2021

This paper is a review of publications on viral infections of the upper aerotract in children. Recurring infections can be a consequence of the lack of treatment, inappropriate therapy or accompanying diseases. It is possible that an impaired condition of immunity leads to recurring infections. In this review a great deal of attention has been given to the mechanisms and the various stages of viral infection, and the onset of an organism’s defense mechanisms against viruses. The function of the immunomodulatory and immunostimulatory medical product, namely inosine pranobex has been evaluated in in vitro and in vivo studies. A review of the antiviral activity of inosine pranobex and the onset of cellular and humoral immunity has been presented.