bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of charged test particles around quantum-corrected Schwarzschild black holes
Authors: Gao Bo , Deng Xue-Mei 
Published: November 2021

AbstractWe investigate neutral and charged test particles’ motions around quantum-corrected Schwarzschild black holes immersed in an external magnetic field. Taking the innermost stable circular orbits of neutral timelike particles into account, we find that the black holes can mimic different ranges of the Kerr black hole’s spin |a/M| from 0.15 to 0.99. Our analysis of charged test particles’ motions suggests that the values of the angular momentumland the energy$$E^{2}$$E2are slightly higher than Schwarzschild black holes. The allowed regions of the$$(l,E^{2})$$(l,E2)demonstrate that the critical energy$$E^{2}_{c}$$Ec2divides the charged test particle’s bounded trajectory into three types. With the help of a Monte Carlo method, we study the charged particles’ probabilities of falling into the black holes and find that the probability density function againstldepends on the signs of the particles’ charges. Finally, the epicyclic frequencies of the charged particles are considered with respect to the observed twin peak quasi-periodic oscillations frequencies. Our results might provide hints for distinguishing quantum-corrected Schwarzschild black holes from Schwarzschild ones by using the dynamics of charged test particles around the strong gravitational field.
Meteorites that produce K-feldspar-rich ejecta blankets correspond to mass extinctions
Authors: Pankhurst M.J. , Stevenson C.J. , Coldwell B.C. 
Published: November 2021

Meteorite impacts load the atmosphere with dust and cover the Earth's surface with debris. They have long been debated as a trigger of mass extinctions throughout Earth history. Impact winters generally last <10
0
years, whereas ejecta blankets persist for 10
3
–10
5
years. We show that only meteorite impacts that emplaced ejecta blankets rich in K-feldspar (Kfs) correlate to Earth system crises (
n
= 11,
p
< 0.000005). Kfs is a powerful ice-nucleating aerosol, yet is normally rare in atmospheric dust mineralogy. Ice nucleation plays an important part in cloud microphysics, which modulates the global albedo. A conceptual model is proposed whereby the anomalous presence of Kfs post impact is posited to have two key effects on cloud dynamics: (1) Kfs reduces the average albedo of mixed-phase clouds, which leads to a hotter climate; and (2) Kfs weakens the cloud albedo feedback mechanism, which increases climate sensitivity. These mechanisms offer an explanation as to why this otherwise benign mineral is correlated so strongly with mass extinction events: every Kfs-rich ejecta blanket corresponds to a severe extinction episode over the last 600 myr. This model may also explain why many kill mechanisms only variably correlate with extinction events through geological time: they coincide with these rare periods of climate destabilization by atmospheric Kfs.

Supplementary material
: Extended Fig. 1 from main text is available at
https://doi.org/10.6084/m9.figshare.c.5690646
The Pan-Tumor Landscape of Targetable Kinase Fusions in Circulating Tumor DNA
Authors: Lee Jessica K. , Hazar-Rethinam Mehlika , Decker Brennan , Gjoerup Ole , Madison Russell W. , Lieber Daniel S. , Chung Jon H. , Schrock Alexa B. , Creeden James , Venstrom Jeffrey , Alexander Brian , Oxnard Geoffrey R. 
Published: November 2021

Abstract

Purpose:
Oncogenic kinase fusions are targetable with approved and investigational therapies and can also mediate acquired resistance (AR) to targeted therapy. We aimed to understand the clinical validity of liquid biopsy comprehensive genomic profiling (CGP) to detect kinase fusions pan tumor.

Experimental Design:
CGP was performed on plasma and tissue samples during clinical care. All exons plus selected introns of 16 kinases involved in oncogenic fusions (ALK, BRAF, EGFR, ERBB2, FGFR1/2/3, MET, NTRK1/2/3, PDGFRA/B, RAF1, RET, and ROS1) were sequenced to capture fusions, including well-characterized and novel breakpoints. Plasma circulating tumor DNA (ctDNA) fraction was estimated to inform sensitivity.

Results:
Of 36,916 plasma cases, 32,492 (88%) had detectable ctDNA. Kinase fusions were detected in 1.8% of ctDNA-positive cases (571/32,492) and were most prevalent in patients with cholangiocarcinoma (4.2%), bladder cancer (3.6%), and non–small cell lung cancer (NSCLC; 3.1%). Of the 63 paired patient samples that had tissue and ctDNA specimens collected within 1 year and with estimated plasma ctDNA fraction &gt;1%, fusions were detected in 47 of 51 (92%) liquid specimens with a fusion in the tissue sample. In 32 patients with fusions detected in liquid but not in tissue, 21 (66%) had evidence of putative acquired resistance.

Conclusions:
Targetable kinase fusions are identified in ctDNA across cancer types. In pairs with tissue-identified fusions, fusion detection in ctDNA is reliable with elevated ctDNA fraction. These data support the validity of CGP to enable ctDNA-based fusion detection for informing clinical care in patients with advanced cancer.
Pyrotinib in Patients with HER2-Amplified Advanced Non–Small Cell Lung Cancer: A Prospective, Multicenter, Single-Arm Trial
Authors: Song Zhengbo , Lv Dongqing , Chen Shi-Qing , Huang Jianjin , Li Yuping , Ying Shenpeng , Wu Xiaoyu , Hua Feng , Wang Wenxian , Xu Chunwei , Bei Ting , Gao Chan , Sun Zhijian , Zhang Yiping , Lu Shun 
Published: November 2021

Abstract

Purpose:
In this study, we aimed to evaluate the efficacy and safety of pyrotinib, a pan-HER inhibitor, in patients with HER2-amplified non–small cell lung cancer (NSCLC).

Patients and Methods:
In this prospective, multicenter, single-arm trial (ChiCTR1800020262), patients with advanced NSCLC with HER2 amplification, as determined by next-generation sequencing, were enrolled and administered pyrotinib orally at 400 mg per day. The primary endpoint was 6-month progression-free survival (PFS) rate. Other endpoints included objective response rate (ORR), disease control rate (DCR), PFS, overall survival (OS), and safety.

Results:
The enrolled cohort included 27 patients with HER2 amplification. The 6-month PFS rate was 51.9% [95% confidence interval (CI), 34.0–69.3]. The median PFS (mPFS) was 6.3 months (95% CI, 3.0–9.6 months), and median OS was 12.5 months (95% CI, 8.2–16.8 months). Pyrotinib elicited a confirmed ORR of 22.2% (95% CI, 10.6%−40.8%). Patients administered pyrotinib as first-line treatment achieved an mPFS of 12.4 months. Moreover, 30.8% of the patients who had progressed on EGFR tyrosine kinase inhibitor (TKI) responded to pyrotinib. Patients with brain metastases had an ORR of 40%. Treatment-related adverse events (TRAE) occurred in all patients (grade 3, 22.2%), but no grade 4 or higher TRAEs were documented. Diarrhea was the most frequent TRAE (all, 92.6%; grade 3, 7.4%). Loss of HER2 amplification was detected upon disease progression.

Conclusions:
Pyrotinib provided antitumor efficacy with a manageable safety profile in HER2-amplified patients with NSCLC.
Hospital and Operator Variation in Cardiac Rehabilitation Referral and Participation After Percutaneous Coronary Intervention: Insights From Blue Cross Blue Shield of Michigan Cardiovascular Consortium
Authors: Sukul Devraj , Seth Milan , Thompson Michael P. , Keteyian Steven J. , Boyden Thomas F. , Syrjamaki John D. , Yaser Jessica , Likosky Donald S. , Gurm Hitinder S. 
Published: November 2021

Background:
Despite its established benefit and strong endorsement in international guidelines, cardiac rehabilitation (CR) use remains low. Identifying determinants of CR referral and use may help develop targeted policies and quality improvement efforts. We evaluated the variation in CR referral and use across percutaneous coronary intervention (PCI) hospitals and operators.

Methods:
We performed a retrospective observational cohort study of all patients who underwent PCI at 48 nonfederal Michigan hospitals between January 1, 2012 and March 31, 2018 and who had their PCI clinical registry record linked to administrative claims data. The primary outcomes included in-hospital CR referral and CR participation, defined as at least one outpatient CR visit within 90 days of discharge. Bayesian hierarchical regression models were fit to evaluate the association between PCI hospital and operator with CR referral and use after adjusting for patient characteristics.

Results:
Among 54 217 patients who underwent PCI, 76.3% received an in-hospital referral for CR, and 27.1% attended CR within 90 days after discharge. There was significant hospital and operator level variation in in-hospital CR referral with median odds ratios of 3.88 (95% credible interval [CI], 3.06–5.42) and 1.64 (95% CI, 1.55–1.75), respectively, and in CR participation with median odds ratios of 1.83 (95% CI, 1.63–2.15) and 1.40 (95% CI, 1.35–1.47), respectively. In-hospital CR referral was significantly associated with an increased likelihood of CR participation (adjusted odds ratio, 1.75 [95% CI, 1.52–2.01]), and this association varied by treating PCI hospital (odds ratio range, 0.92–3.75) and operator (odds ratio range, 1.26–2.82).

Conclusions:
In-hospital CR referral and 90-day CR use after PCI varied significantly by hospital and operator. The association of in-hospital CR referral with downstream CR use also varied across hospitals and less so across operators suggesting that specific hospitals and operators may more effectively translate CR referrals into downstream use. Understanding the factors that explain this variation will be critical to developing strategies to improve CR participation overall.
Racializing a New Nation: German Coloniality and Anthropology in Maharashtra, India
Authors: Barbosa Thiago P. 
Published: November 2021

Abstract
This paper deals with the transnationalism of racial anthropological frameworks and its role in the understanding of human difference during India’s decolonization and nation-building. With attention to the circulation of scientific objects, I focus on the practices and articulations of Irawati Karve (1905–1970), an Indian anthropologist with a transnational scientific trajectory and nationalistic political engagements. I argue that Karve’s adaptation of an internationally validated German racial approach to study caste, ethnic and religious groups contributed to the further racialization of these categories as well as to the racialization of nationalistic projects in Maharashtra and India. I conclude with a reflection on the transnationalization of the coloniality of racialization.
Populism and ‘People’: Precarities and Polarizations as a Challenge and Task for a Public Theology
Authors: von Sinner Rudolf , Gabatz Celso 
Published: November 2021

Abstract
Two main elements pervade the argument. First, we argue that both ‘populism” and ‘the people’ are precarious concepts that can neither easily be defined, nor easily be claimed by any representative. We hold this to be true both in political and in theological terms, empirically referring to the civil and the religious population and their construction as ‘a people’, respectively. Second, in view of a common disregard for the people, namely as plebs, we reaffirm the importance of participatory popular subjects as a necessary part of both the political system and Christian communities. This bibliographical and conceptual essay contextualizes and explains the precariousness of realities and concepts, then analyses the concepts of populism and ‘people’. It seeks to deepen the discussion of populism by means of dialogue with Ernesto Laclau and Chantal Mouffe, and then through a theological reflection by way of a public theology.
‘The Palestinian Talmud Was Not Tampered with by the Pens of Emenders’: Clarifying a Textual Version Rule
Authors: Yahalom Shalem 
Published: November 2021

Abstract
This article will demonstrate that Nahmanides’s statement regarding the unamended Palestinian Talmud relates to the sources cited in that work. The advantage of the Palestinian Talmud stemmed from the neglect suffered by that work which enabled it to escape the hegemony of the Babylonian Talmud whose textual versions were imposed on all other Oral Torah works. Of course, it also stemmed from the proximity of the Palestinian Talmud in both time and place to the Mishnah and Tosefta. This advantage lent great significance to the exegesis of these sources in the Palestinian Talmud.
Two new Diptacus and one new Trimeroptes species (Acari: Diptilomiopidae) from China
Authors: TAN MENG-CHAO , LV AN-KANG , RUAN HONG-YAN , ZHAO PING 
Published: November 2021

Two new Diptacus species and one new Trimeroptes species (Acari: Eriophyoidea: Diptilomiopidae) are described and illustrated from China: Diptacus suichangensis sp. nov. on Aralia chinensis L. (Araliaceae) and Diptacus pyracanthae sp. nov. on Pyracantha fortuneana (Maxim.) Li (Rosaceae), and Trimeroptes longlinensis sp. nov. on Carpinus sp. (Betulaceae). These new species were found to be vagrant on the lower surface of their associated plants leaves, albeit with no apparent damage observed.
The Role of Latent Heating Anomalies in Exciting the Summertime Eurasian Circulation Trend Pattern and High Surface Temperature
Authors: Kim Dong Wan , Lee Sukyoung 
Published: November 2021

AbstractDynamical mechanisms for the summer Eurasian circulation trend pattern are investigated by analyzing reanalysis data and conducting numerical model simulations. The daily circulations that resemble the Eurasian circulation trend pattern are identified and categorized into two groups based on surface warming signal over central and eastern Europe. In the group with large warm anomaly, the upper-level circulation takes on a wave packet form over Eurasia, and there are enhanced latent heating anomalies centered over the North Sea and suppressed latent heating anomalies over the Caspian Sea. The numerical model calculations indicate that these latent heating anomalies can excite an upper-level circulation response that resembles the Eurasian circulation trend pattern. Additional analysis indicates that trends of these two latent heating centers contribute to the long-term circulation trend. In the weak warm anomaly group, the circulation pattern takes on a circumglobal teleconnection (CGT) pattern, and there is no heating signal that reinforces the circulation. These results indicate that not all CGT-like patterns excite temperature anomalies that are persistent and in phase with the trend pattern, and that quasi-stationary forcings, such as the latent heating anomalies, play an important role in driving the boreal summer circulation anomaly that accompanies the strong and persistent surface temperature signal.
Revisit of the Occurrence of the Kuroshio Large Meander South of Japan
Authors: Qiu Bo , Chen Shuiming 
Published: November 2021

AbstractA unique characteristic by the Kuroshio off the southern coast of Japan is its bimodal path variations. In contrast to its straight path that follows the coastline, the Kuroshio takes a large meander (LM) path when its axis detours southward by as much as 300 km. Since 1950, eight Kuroshio LM events took place and their occurrences appeared random. By synthesizing available in situ/satellite observations and atmospheric reanalysis product, this study seeks to elucidate processes conducive for the LM occurrence. We find neither changes in the inflow Kuroshio transport from the East China Sea nor in the downstream Kuroshio Extension dynamic state are determinant factors. Instead, intense anticyclonic eddies with transport > 20 Sv (1 Sv ≡ 106 m3 s−1) emanated from the Subtropical Countercurrent (STCC) are found to play critical roles in interacting with Kuroshio path perturbations southeast of Kyushu that generate positive relative vorticities along the coast and lead the nascent path perturbation to form a LM. Occurrence of this intense cyclonic–anticyclonic eddy interaction is favored when surface wind forcing over the STCC is anticyclonic during the positive phasing of Pacific decadal oscillations (PDOs). Such wind forcing strengthens the meridional Ekman flux convergence and enhances eddy generation by the STCC, and seven of the past eight LM events are found to be preceded by 1–2 years by the persistent anticyclonic wind forcings over the STCC. Rather than a fully random phenomenon, we posit that the LM occurrence is regulated by regional wind forcing with a positive PDO imprint.
Investigation of the implementation of a Communication Enhanced Environment model on an acute/slow stream rehabilitation and a rehabilitation ward: A before-and-after pilot study
Authors: D’Souza Sarah , Godecke Erin , Ciccone Natalie , Hersh Deborah , Armstrong Elizabeth , Tucak Claire , Janssen Heidi 
Published: November 2021

Objectives: Develop and implement a Communication Enhanced Environment model and explore its effect on language activities for patients early after stroke. Method and design: Before-and-after pilot study. Setting: An acute/slow stream rehabilitation and a rehabilitation ward in a private hospital in Perth, Western Australia. Participants: Fourteen patients recruited within 21 days of stroke. Seven recruited during the before-phase (control group: patients with aphasia = 3, patients without aphasia = 4) and seven recruited in the after-phase (intervention group: patients with aphasia = 4, patients without aphasia = 3). Intervention: The intervention group exposed to a Communication Enhanced Environment model had access to equipment, resources, planned social activities and trained communication partners. Both groups received usual stroke care. Data collection: Hospital site champions monitored the availability of the intervention. Behavioural mapping completed during the first minute of each 5-minute interval over 12 hours (between 7 am and 7 pm) determined patient engagement in language activities. Results: Seventy-one percent of the Communication Enhanced Environment model was available to the intervention group who engaged in higher, but not significant (95% CI), levels of language activities (600 of 816 observation time points, 73%) than the control group (551 of 835 observation time points, 66%). Unforeseen reorganisation of the acute ward occurred during the study. Conclusions: Implementation of a Communication Enhanced Environment model was feasible in this specific setting and may potentially influence patients’ engagement in language activities. The unforeseen contextual challenges that occurred during the study period demonstrate the challenging nature of the hospital environment and will be useful in future research planning.
Influence of tomographic and biomechanical corneal indexes on myopic refractive surgery indications: A multicenter study
Authors: Duch Francesc , López-Marín Ignacio , Alonso-Aliste Federico , Hernández-Barahona-Campos Mariano , Manito Santiago C , Sánchez-Trancón Ángel , Cadarso Luís , Sánchez-González José-María , Fernández Joaquín 
Published: November 2021

Purpose To evaluate the influence of corneal tomographic and biomechanical indexes on the refractive technique indication. Methods A total of 251 eyes from 251 patients interested in refractive surgery were enrolled in this cross-sectional and multicenter study. Previous to the surgeon decision, a preoperative protocol was performed by refractive optometrists, containing four sections: refraction, biometry, corneal tomography and biomechanics. The refractive surgeons made a first decision based only on refraction, biometric and tomographic information. Biomechanical indexes were revealed, and refractive surgeons made a second indication. Additionally, for Laser-Assisted in-situ Keratomileusis cases, the percent tissue altered were calculated. Possible indications were no refractive surgery, photorefractive keratectomy, Laser-Assisted in-situ Keratomileusis or intraocular Collamer lens. Results After the first surgery indication, the distribution was photorefractive keratectomy (47.4%), Laser-Assisted in-situ Keratomileusis (48.2%) while intraocular Collamer lens achieved 2.8%. This proportion changed significantly after the second indication regarding corneal biomechanics and photorefractive keratectomy and Laser-Assisted in-situ Keratomileusis decreased by 24% while intraocular Collamer lens increased 19%. A total of 69 eyes changed the indication (27.5%) and 182 eyes (72.5%) remained unchanged. All indications changes were from photorefractive keratectomy or Laser-Assisted in-situ Keratomileusis to intraocular Collamer lens or no surgery. Indication changes to intraocular Collamer lens were observed in 49 eyes (71%). Tomographic, biomechanical indexes, ablation depth and percent tissue altered achieved statistically significant differences between eyes without and with indication changes (all, P < .01). Conclusion New corneal biomechanical indexes could change the indication decision regarding biometric and tomographic data alone. Intraocular Collamer len was the preferred indication for eyes at risk of ectasia or with subclinical keratoconus due to corneal biomechanical parameters.
Efficacy and safety of vitamin supplements with resveratrol in diabetic macular edema: Long-term results of a comparative study
Authors: Chatziralli Irini , Dimitriou Eleni , Chatzirallis Alexandros , Aissopou Evaggelia , Kazantzis Dimitrios , Theodossiadis George , Theodossiadis Panagiotis 
Published: November 2021

Purpose To investigate the adjunct efficacy and safety of vitamin supplements, including resveratrol, in patients with diabetic macular edema (DME) treated with intravitreal anti-vascular endothelial factor (anti-VEGF) agents. Methods Participants in this prospective study were 45 patients with DME, who were treated with either intravitreal anti-VEGF injections (n = 23, Group I) or with combination of intravitreal anti-VEGF injections and vitamin supplements, including resveratrol (n = 22, Group II). All patients underwent visual acuity measurement, slit-lamp examination and spectral domain-optical coherence tomography (SD-OCT) at baseline and monthly after the loading phase of three-monthly anti-VEGF injections, following a PRN protocol. Results There was a statistically significant improvement in visual acuity in both groups at month 12 compared to baseline, although the mean change in visual acuity did not differ between the two groups (p = 0.183). Accordingly, there was a statistically significant decrease in central retinal thickness in both groups at month 12 compared to baseline, while the mean difference in central retinal thickness was significantly greater in the “combination” group. The mean number of intravitreal anti-VEGF injection was less in Group II (6.45 ± 1.12 in Group II vs. 7.39 ± 1.31 in Group I, p = 0.018). Conclusions Vitamin supplements with resveratrol was found to be an effective adjunct to intravitreal anti-VEGF injections in patients with DME, offering better anatomic restoration with less injections at the 12-month follow-up.