bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data transmission with Simulink on 6-DoF platform on CAN BUS
Authors: Mikhailov V. G. 
Published: April 2021

Use of CAN BUS for data transmission in Real-Time mode with Simulink on control objects is considered (6-DoF a platform).It is revealed that software of CAN_ API.dll adapters, created in the Microsoft Visual Studio (MVS) does not work with TDM-GCC-64 Matlab/Simulink because of different approach in names of the dll functions according to the standard C ++ 11/17. Recompile by the developer of the adapter of its software (dll) in the TDM-GCC-64 environment under Windows is required.It is established that CAN BUS considerably reduces modeling speed by 4.5 times. The way of information compression and fall forward of exchange twice due to byte-by-byte entering of two float values in the data field is offered. Use of identical values of identifiers is applied to two cylinders 6-DoF of a platform and the subsequent their division in the program microcontrollers of cylinders.For implementation of a Real-Time mode in addition to compression it is offered to transfer data with the smaller frequency (quantization) by what a modeling clock period. It was considered that 6-DoF platforms reproduce frequency band to 10–12 Hz. The program of transfer/data exchange with Simulink on stand control devices with quantization is developed. Influence of parameter of quantization for the period of modeling is investigated. It is established that the Real-Time mode of modeling is provided in the range of parameters of quantization (chc=1/350–1/1000). Frequency of exchange with 6 cylinders at the same time corresponds to 230, 150 Hz.
Accurate Recommendation Approach of Psychological Consultation Information Based on User Portrait and TAG_SVD_CF
Authors: Zhang De-gan , Liu Zi-xian , Fu Tian-zheng , Zhang Xin , Wen Kai-yan , Liu Bing 
Published: April 2021

Abstract
A hybrid recommendation algorithm of psychological counseling information based on user profile and item tag attribute with singular value decomposition(SVD) technology is developed. To solve the problem of data sparsity of the recommendation algorithm, the SVD technology is applied to collaborative filtering algorithm for optimizing the user item rating matrix. The recommendation algorithm includes two parts: generating medical user profile in accurate recommendation of medical information, and realizing the storage, query and update of user profile, where the index system of medical portrait was established from demographic attribute, interest label dimension and business social dimension. The performances of the developed algorithm are investigated by compared with the traditional cosine similarity and Pearson similarity. The results show that the proposed similarity has a lower mean absolute error and significantly improves the accuracy of the system.
Patterns in spatial use and movement of Silver Carp among tributaries and main-stem rivers: Insight from otolith microchemistry analysis
Authors: Werner Jacob P , Dean Quintin J , Pegg Mark A , Hamel Martin J 
Published: April 2021

Abstract
Invasive Silver Carp (Hpophthalmichthys molitrix) have established populations throughout the Missouri River basin, including in the Kansas River. Understanding the spatial extent under which these invasive fish function in large, open river systems is crucial to inform management efforts. The Kansas River may play a vital role in the life-cycle of Silver Carp in the Missouri River basin as the main-stem Missouri River has undergone a multitude of alterations, creating a channel with greater mean depths and velocities. Here, we used otolith microchemistry of Silver Carp from the Kansas River to reconstruct environmental histories as a means to assess the proportions of resident and transient individuals. Silver Carp within the Kansas River were predominantly residents (adults = 54%; juveniles = 65%) with the majority of reproduction coming from within the Kansas River itself. These results suggest removal efforts in the Kansas River may be effective means of managing this invasive fish species. Transient individuals exhibited short durations of signatures indicative of the Missouri River (mean percent of data points for adults = 10% and juveniles = 36%), suggesting movements into the Missouri River were brief. These results highlight the importance of connectivity of tributary habitat among large rivers and provides important information for invasive species management.
Early Postoperative Effects of Uncomplicated Phacoemulsification Surgery on Corneal Endothelial Cells and Thickness in Patients with Pseudoexfoliation Syndrome
Authors: EKİCİ EREN , Keles Ali , Kahraman Süleyman Korhan 
Published: April 2021

Abstract
Purpose: To compare early postoperative effects of uncomplicated phacoemulsification surgery on corneal endothelial cells and thickness in patients with pseudoexfoliation syndrome (PEX).Methods: One eye each of 32 patients with PEX and 32 age-matched non-PEX subjects was evaluated preoperatively and on 1st, 7th, and 30th days after uncomplicated phacoemulsification surgery in this retrospective case-control study. Nuclear firmness, corneal edema (CE), anterior chamber reaction (ACR) intensity were graded by a slit-lamp microscope. Endothelial cell density (ECD), coefficient of variation in cell area (CV), hexagonal cell ratio (HEX), and central corneal thickness (CCT) were measured using a noncontact specular microscope.Results: There was no significant group-difference in age, sex, corneal edema (CE), anterior chamber reaction (ACR), coefficient of variation in cell area (CV), and hexagonal cell ratio (HEX). Mean effective phaco time (EPT) was significantly lower intraoperatively (p<0.001) and logarithm of the minimum angle of resolution (logMAR) values of best-corrected visual acuity (BCVA) were significantly higher on both 1st (p<0.001), 7th (p=0.011), and 30th (p=0.025) days postoperatively in the PEX group than in the non-PEX group. Mean ECD was significantly lower in the PEX group than in the non-PEX group on 7th (p=0.013), and 30th (p=0.037) days postoperatively. The mean CCT significantly differed only on 1st (p<0.001) day postoperatively.Conclusion: Eyes with PEX presented lower corneal ECD and decreased BCVA after uncomplicated phacoemulsification surgery. Further, there was no association between CCT and PEX existence preoperatively and in the early postoperative period.
Risk Assessment at Puerto Vallarta due to a Local Tsunami.
Authors: Gomez Elizabeth Trejo , Núñez-Cornú Francisco Javier 
Published: April 2021

Abstract
The Jalisco region in western Mexico is one of the most seismically active in the country. The city of Puerto Vallarta is located at Bahía de Banderas on the northern coast of Jalisco., Currently there exists a Seismic Gap in the Northern coast of Jalisco (Vallarta Gap). Historically seismogenic tsunamis have affected the coast of Jalisco. In this work, the risk due to a local tsunami in the city of Puerto Vallarta is a function of the interaction between hazard and vulnerability. We model the tsunami hazard, generation and propagation, using the initial conditions for a great earthquake (Mw ≥ 8.0) similar to those that occurred in 1787 at Oaxaca and in 1995 at Tenacatita Bay, Jalisco. Vulnerability is estimated with available data for the years 2010–2015 with sociodemographic variables and the location of government, commercial or cultural facilities. The area with the highest vulnerability and risk is between the valleys of the Ameca and Pitillal Rivers, extending to a distance greater than 5.1 km from the coastline and affecting an area of 30.55 km2. This study does not consider the direct damage caused by the tsunamigenic earthquake and aftershocks; it assumes that critical buildings in the region, mostly hotels, would not collapse after the earthquake and could serve as a refuge for its users. The first (It) tsunami wave arrives to Puerto Vallarta (Cuale) 19 min after the earthquake with a height (Hi) of 3.7 m, the Run Up (At) arrives 74 min after earthquake with a height (Hr) of 5.6 m.
Calcitriol Exerts Prophylactic Anti-Mycobacterium Effect In A Dose-Dependent Manner
Authors: Li Jianguo , Li Zhen , Gao Zefeng , Xia Juan , Cui Jia , Zhang Jialei , Wu Changxin 
Published: April 2021

Abstract
Vitamin D was empirically applied for Tuberculosis (TB) treatment in the past, and is currently used as an adjuvant for TB therapy. Although an increasing pile of evidences suggests that vitamin D has no therapeutic effect against TB infection, the prophylactic effect of vitamin D in preventing TB remains largely undetermined. To experimentally valuate the potential prophylactic effect of calcitriol (the active form of vitamin D) against mycobacterium infection, we performed dose-gradient calcitriol soaking in 30-day-old zebrafish before Mycobacterium marinum (M. marinum) challenge through tail vein injection. 1H-NMR metabolomics analysis was further performed for illustration of potential mechanisms underlying the prophylactic effect of calcitriol against M. marinum. The results suggested that calcitriol exerts dose-dependent prophylactic anti-mycobacterium effects, i.e., the bacterial load and the corresponding inflammatory factors (IL-1β, TNF-α, and IFN-γ) expressions in M. marinum challenged zebrafish were reduced by low-dose (25 µg/L) or high-dose (2500 µg/L) calcitriol soaking, rather than by moderate-dose (250 µg/L) calcitriol soaking. Body weight of the M. marinum challenged zebrafish was recovered by high-dose prophylactic calcitriol soaking rather than by low-dose or moderate-dose calcitriol. The 1H-NMR metabolomic profiling identified 29 metabolites with altered abundance among the dose-gradient calcitriol groups, among which 22 metabolites were co-varied with the dose of calcitriol, the rest 7 metabolites were co-varied with the bacterial load and the inflammatory response in term of cytokine expression. Further pathway analysis indicated that the glycine, serine, and threonine metabolism pathway was the activated in both of the two metabolite groups, indicating that the pathway was altered by dose-gradient of calcitriol and was in response to M. marinum infection in zebrafish. The results of the present study suggested that the activation of glycine, serine and threonine metabolism pathway may play a potential role for the dose-dependent anti-mycobacterium effect induced by prophylactic calcitriol soaking.
Nutrient Intake, Dietary Patterns, and Anthropometric Indices of Children with ADHD in Comparison to Healthy Controls: A Case-Control Study
Authors: Salvat Habibeh , Mohammadi Mehriar Nader , Molavi Parviz , Mostafavi Seyed Ali , Rostami Reza , Salehinejad Mohammad Ali 
Published: April 2021

Abstract
Background: Poor health behaviors and indices are recently reported in Attention-deficit hyperactivity disorder (ADHD) lifestyle which might be relevant to the pathophysiology of this disorder. The objective of this case-control study was to assess the nutrient intake, dietary patterns, and anthropometric indices in ADHD children compared to normal peers. Method: 100 children diagnosed with ADHD were included and compared to healthy, sex-matched normal children as the control group. Anthropometric indices, macronutrients, and micronutrients were measured and compared in both groups. Results: ADHD children were significantly consuming more simple sugars, tea, ready-made meals but less protein, vitamin B1, vitamin B2, vitamin C, zinc and calcium compared to the control group. The body mass index (BMI) and waist circumference of ADHD children were significantly higher and were related to the severity and type of the disease. Conclusion: Unhealthy lifestyle behavior is higher in ADHD which might warrants lifestyle intervention in this disorder.
Generation of Reducing Sugars from Corncob by Magnetic Carbon-Based Solid Acid Pretreatment Combined with In Situ Enzymatic Hydrolysis
Authors: Lu Si , Wang Qiong , Wang Xiaoman , Liang Cuiyi , Fu Juan , Xu Zihan , Wang Zhongming , Yuan Zhenhong , Yue Jun , Qi Wei 
Published: April 2021

Abstract
The efficient conversion of hemicellulose and cellulose in lignocellulosic biomass to reducing sugars remains as one major challenge for the development of biorefinery. In this work, corncob saccharification in the aqueous phase was realized efficiently via pretreatment by magnetic carbon-based solid acid (MMCSA) catalyst, combined with the subsequent in situ enzymatic hydrolysis (occurring in the same pretreatment system after MMCSA separation). Under the optimized pretreatment conditions (the ratio of corncob, catalyst and water is 1:1:20 (g:g:mL), 160°C for 20 min) and in situ enzymatic hydrolysis (cellulase loading of 20 FPU / g, 24 h), an xylose yield of 88.77% and an enzymatic digestibility of 91.24% were obtained, respectively. Compared with the traditional enzymatic process, the present in situ enzymatic system has advantages of reduced enzyme loading, water consumption, and improved saccharification efficiency. Thus, this study provides a more sustainable and effective method for the saccharification of hemicellulose and cellulose in the corncob to produce reducing sugars.
Evaluating the Relationship Between Disease Severity and Serum Levels of Zinc, Calcium and Vitamin D in COVID-19 Patients
Authors: Jahangirimehr Azam , Khalighi Azam , Shahvali Elham Abdolahi , Labibzadeh Mostafa , Bahmanyari Nasrin 
Published: April 2021

Abstract
IntroductionSARS-CoV-2 is spreading rapidly worldwide these days so that it has infected people in many countries. It is a zoonotic virus and the cause of COVID-19 infectious pneumonia. The World Health Organization (WHO) declared it a pandemic on January 30, 2020. Given that no standard treatment has been found for the new coronavirus so far, the present study seeks a way to reduce the incidence and severity of the disease along with health protocols. Some of the factors possibly effective in getting less infected by the SARS-CoV-2 are|taking medication supplements such as zinc, calcium, and vitamin D.Materials and methodsThis cross-sectional study was conducted from May 13 to May 30, 2020, on 93 COVID-19 patients admitted to Khatam Al-Anbia Hospital in Shushtar in southwestern Iran. Some patients' laboratory and clinical of were collected and analyzed using the Chi-squared test, the independent t-test, the Kruskal-Wallis test, and the Spearman rank-order correlation coefficient by IBM SPSS Statistics 18.0 software.FindingsThe severity of the disease (40%) of 37 patients was severe in pulmonary involvement. Serum levels of vitamin D and zinc were lower than the average in all patients. Still, the severity of COVID-19 in patients was not significantly different from their zinc serum levels (P = 0.216). Serum vitamin D was not significantly different (P = 0.102). The severity of COVID-19 in patients was significantly different according to serum calcium levels (P = 0.005). The lower the calcium level, the more severe the disease.ConclusionGiven that the supplementation's effect in preventing COVID-19 has not been confirmed and no study has been published on the appropriate dose of these supplements in COVID-19, taking economically viable calcium-rich food sources, including dairy, is recommended.
Whole Genome Sequence based Capsular Typing and Antimicrobial Resistance Prediction of Group B Streptococcal Isolates from Colonized Pregnant Women in Nigeria
Authors: Bob-Manuel Mienye , McGee Lesley , Igunma Jeremiah , Alex-Wele Mary , Obunge Orikomaba , Wariso Kennedy 
Published: April 2021

Abstract
Background: Streptococcus agalactiae (Group B Streptococcus, GBS) is one of the major bacterial pathogens responsible for neonatal sepsis. Whole genome sequencing has, in recent years, emerged as a reliable tool for capsular typing and antimicrobial resistance prediction. This study characterized vaginal and rectal isolates of Group B Streptococcus obtained from pregnant women in Port Harcourt, Nigeria using a whole-genome sequence-based approach.Results: Capsular types Ia, Ib, II, III, IV and V were detected among the 43 isolates sequenced. Twelve sequence types (STs) were identified, with ST19 (n=9, 27.3%) and ST486 (n=5, 15.2%) the most frequent among non-duplicated isolates. Of the alpha-like proteins (alp) identified, Alp1 was the most prevalent in 11 (33.3%) isolates. Macrolide and lincosamide resistance determinants were present in 15 (45.5%) isolates; ermB was detected in 1 (3%) and ermTR in 7 (21.2%) isolates. The lnu gene, was detected in 6 (18.2%) and mef was identified in 3 (9.1%) isolates. Resistance of GBS to erythromycin and clindamycin was found to be 30.3% and 24.2%, respectively. All isolates were resistant to tetracycline with only the tetM gene identified. Fluoroquinolone-resistance conferring substitutions in gyrA + parC were detected in 9 (27.3%) isolates and chloramphenicol resistance was predicted in 11 (33.3%).Conclusion: The data available from the whole genome sequencing of these isolates offers a small but insightful description of common serotypes and resistance features within colonizing GBS in Nigeria.
The Effectiveness of Intervention Based on the Transactional Model on Improving Coping Efforts and Stress Moderators in Hemodialysis Patients in Tehran
Authors: Ghaffari Mohtasham , sharifabad Mohammad Ali Morowati , Jadgal Mohammad Saeed , Mehrabi Yadollah , alizadeh somayeh 
Published: April 2021

Abstract
Background: Present study was conducted to determine the effect of training on coping efforts (CE) and stress moderators, based on transactional model of Lazarus and Folkman, in hemodialysis patients (HD). Methods: This is a randomized controlled clinical trial on 116 hemodialysis patients referred to dialysis centers in Tehran from May to August 2018. The patients were assigned to two experimental and control groups using a simple randomization method. The intervention included 6 training sessions in the form of CE and moderators of transactional model. Data were collected before and 3 months after the intervention. Data were analyzed using SPSS 16.Results: After 3 months training intervention, there was significant increase in the intervention group in the mean scores of CE (P<0.001), moderators and subscales of emotional regulation (ER) from 51.18 ± 20.42 to 64.87 ± 13.18 (P<0.001), dispositional coping style (DCS) from 45.56± 19.45 to 55.84± 18.03 and social support (SS) from 49.61 ±20.14 to 55.55 ± 17.35 (P<0.005).Conclusion: The training based on transactional model was successful in the increase of SS, DCS and ER in (HD). Therefore, Nurses and healthcare providers can use this program to help (HD) to increase their adaptation to the illness and reduce stress.
Cytosine base editing systems with minimized off-target effect and molecular size
Authors: Li Ang , Mitsunobu Hitoshi , Yoshioka Shin , Takahisa Suzuki , Kondo Akihiko , Nishida Keiji 
Published: April 2021

Abstract
Structure-based rational engineering of the cytosine base editing system Target-AID was performed to minimize its off-target effect and molecular size. By intensive and careful truncation, DNA-binding domain of its deaminase PmCDA1 was eliminated and additional mutations were introduced to restore enzyme function. The resulting tCDA1EQ was effective in N-terminal fusion (AID-2S) or inlaid architecture (AID-3S) with Cas9, showing minimized gRNA-independent off-targets, as assessed in yeast and human cells. Combining with the smaller Cas9 ortholog system, the smallest cytosine base editing system was created that is within the size limit of AAV vector.
Qualitative Assessment of Barriers to Rural Health Care in Pennsylvania
Authors: Maganty Avinash , Hamm Megan , Wasilko Rachel , Sabik Lindsay M , Davies Benjamin J , Jacobs Bruce L 
Published: April 2021

Abstract
Introduction: Rural populations routinely rank poorly on common health indicators including urologic cancer-specific mortality. While it is understood that rural residents face barriers to healthcare, the exact nature of these barriers has not been well described. In order to define these barriers, we performed a qualitative study to directly identify primary care physician perspective on healthcare access in rural areas. Methods: From January to August 2019, we conducted semi-structured interviews with 20 primary care physicians practicing in rural areas within western Pennsylvania. We purposively sampled primary care physicians in rural counties in Pennsylvania. We then recruited additional participants using a snowball recruitment strategy, in which the initial interviewees recommend other potential participants in their field. Data was then transcribed, coded, and analyzed via thematic analysis. Results: Participants identify the following as major healthcare barriers rural residents face: access to specialists, lack of transportation to medical centers, and financial burden. Financial barriers impact patients’ willingness to obtain screenings measures and attend specialist appointments secondary to co-pays. Primary care physicians report patients experience numerous hardships after being referred to a specialist, as they often have to travel long distances, lack means of transportation, are unwilling to skip work, have low healthcare literacy, and tend to be suspicious of medical treatment. Conclusion: Rural residents face numerous barriers to obtaining healthcare. Policy to rectify this disparity should focus on improving local access to care, transportation to tertiary care centers, and financial assistance for preventative screening measures.
Title: Fatigue is the predominant patient-reported outcome measure in hemodialysis patients: Results of a multicenter cross-sectional ePROMs Study
Authors: Guerraoui Abdallah. , Prezelin-Reydit Mathilde. , Kolko Anne. , Lino-Daniel Marie. , Roque Charlotte. Dumas , Urena Pablo. , Chauveau Philippe. , Lasseur Catherine. , Haesebaert Julie. , Caillette-Beaudoin Agnes. 
Published: April 2021

Abstract
Background: End Stage renal disease (ESRD) and hemodialysis are associated with a decrease in quality of life (QOL). Self-reported QOL symptoms are not always prioritized by the medical team, potentially leading to conflicting priorities with patients. Electronic patient-reported outcome measures (ePROMs) allow physicians to better identify these symptoms. The objective was to describe the prevalence of symptoms self-reported by hemodialysis (HD) patients.Methods: A multicenter cross-sectional study was conducted in three HD centers. Patients were included if they were 18 years old or over and treated with HD for at least three months in a center. Data were collected by the patient via a self-administered ePROMs questionnaire. Data included patient characteristics, post-dialysis fatigue and intensity, recovery time after a session, perceived stress, impaired sleep the day before the dialysis session, current state of health, and the one-year change. Results: In total, we included 173 patients with a mean age of 66.2 years, a mean ± SD hemodialysis duration of 48.9 ± 58.02 months. They were mainly treated in self-dialysis unit (67%) with at least one comorbidity (72.5%). The prevalence of fatigue was 72.1%. 66.4% had a high level of stress (level B or C). Recovery time was more than 6 hours after a HD session for 24.9% of patients and 78 % declared they had a better or unchanged health status than the previous year. Sleep disturbance was associated with cardiovascular comorbidities. Conclusions: Fatigue and stress were the main symptoms reported by HD patients. The patient’s care teams should better consider these symptoms.Trial registration: Commission Nationale de l'Informatique et des Libertés (CNIL): N° 2214737V0, Date First Registered: 2019-08-20. The CPP (Patient Protection Committee) Ile-de-France VII (2019-12-26) in accordance with French regulations N° ID-RCB: 2019-AO1373-54. Date First Registered: 2019-08-19.All methods were carried out in accordance with the relevant guidelines and regulations. Informed consent was obtained from all subjects, no subjects were under 18 years of age