bluuebunny/crossref_metadata_2025_split huggingface dataset:
ІСТОРІОГРАФІЧНИЙ ДИСКУРС ПРОБЛЕМИ ВЗАЄМОДІЇ УЧИТЕЛІВ ІЗ БАТЬКАМИ МОЛОДШИХ ШКОЛЯРІВ
Authors: Чаговець А. І. 
Published: February 2021

У статті здійснено історіографічний дискурс проблеми взаємодії учителів із батьками молодших школярів. Важливість проблеми взаємодії учителів із батьками молодших школярів окреслена в працях класиків педагогічної думки, визначена сучасними науковцями, педагогами-практиками, нормативно-правовою базою та вимогами суспільства, що й підкреслює її актуальність. Сім’я та школа – два суспільних інститути, на яких покладено обов’язок виховувати особистість. Визнаючи школу провідною ланкою у розвитку особистості, треба зазначити, що без співпраці з сім’єю, ефективність цього процесу буде низькою. Визначено, що школа ХХІ століття – це відкрита виховна система, орієнтована на модернізацію і урізноманітнення сімейно-шкільної взаємодії. Щоб забезпечити системність і послідовність процесу формування педагогічної культури батьків важливо уже з першого року навчання і виховання дітей у школі зробити батьків співучасниками педагогічного процесу, на це орієнтована Нова українська школа (НУШ). З’ясовано, що в сучасному суспільстві посилюється увага до проблеми взаємодії сім’ї і школи, учені розробляють і реалізують комплексні цільові програми задля підвищення значущості її впливу на виховання дітей, що стимулює потребу молодих батьків бути активними учасниками педагогічного процесу в закладі загальної середньої освіти, особливо в початковій школі. Результати аналізу психолого-педагогічної та наукової літератури засвідчують, що взаємодія учителів та батьків молодших школярів, їх об’єднані зусилля та співпраця сприяють забезпеченню всебічного та гармонійного розвитку особистості.
ПІДГОТОВКА МАЙБУТНІХ МАГІСТРІВ СПЕЦІАЛЬНОЇ ОСВІТИ ДО ПРОФЕСІЙНОГО САМОВДОСКОНАЛЕННЯ У ЗВО
Authors: Джус О. В. , Потапчук Т. В. , Покутнєва С. О. , Труш Н. В. 
Published: February 2021

Стаття присвячена дослідженню стану підготовки майбутніх магістрів спеціальної освіти до професійного самовдосконалення у ЗВО. Акцентовано увагу на тому, що таку підготовку має забезпечувати вищий заклад освіти, який сьогодні повинен відповідати не тільки індивідуальним потребам особистості щодо навчання, а й соціальним запитам. Оскільки сучасна вища освіта в Україні спрямована на забезпечення фундаментальної наукової, практичної, загальнокультурної підготовки конкурентоспроможних фахівців та формування інтелектуального потенціалу країни. Тому сучасні вимоги до освіти в Україні, необхідність запровадження нових наукових підходів і гуманістичних концепцій навчання та виховання актуалізують проблему якісного поліпшення підготовки майбутніх спеціальних педагогів та майбутніх магістрів спеціальної освіти у закладах вищої освіти.
У статті наголошується, що студент стане справжнім магістром спеціальної освіти тільки тоді, як він сам працює над своєю особистістю та проявляє активність щодо оволодіння науковими знаннями і вміннями, наскільки цілеспрямовано, свідомо та наполегливо працює над розвитком у собі тих дрібниць, що формують особистість сучасного фахівця. У спеціальній педагогіці й спеціальній психології така робота має назву самовиховання і саморозвитку.
У статті зазначено, що професійне самовдосконалення майбутніх магістрів спеціальної освіти пов’язане із самопошуком і самоздійсненням професійного вибору системи «спеціальний педагог» як сукупності взаємопов’язаних елементів, що сприяє розвитку нових якостей та властивостей означеної системи, та усвідомленням себе та власної значущості як спеціального педагога у професійно-педагогічному світі, який здатний взаємодіяти з іншими суспільними системами.
PENGEMBANGAN USAHA MIKRO JAMUR TIRAM PUTIH (STUDI KASUS : PEMBUATAN ALAT KONTROL SUHU, KELEMBABAN DAN PEMBUATAN WEBSITE PEMASARAN BENTENG HILIR-DELI SERDANG)
Authors: Parinduri Ikhsan , Iskandar Iskandar 
Published: February 2021

Abstract: Has been Community Service for Micro-Business White Oyster Mushroom "Temperature control and humidity, Lower Fortress, Deli Serdang. Temperature control and humidity of white oyster mushrooms using Ardurino Uno R-3-based DHT 11 temperature sensor with 16x2 LCD display and HP Android. Controlling the temperature and humidity of white oyster mushrooms work automatically to help the mushroom farmers in controlling the temperature and humidity of white oyster mushroom kumbung .. If temperature> 300C and humidity <650C sensors will read the temperature and humidity in the kumbung and regulate the movement of the water pump in automatic and turn the water nozzle in water spraying onto the kumbung section and baglog mushrooms. This tool works to help white oyster mushroom farmers in increasing their harvest production. Keywords: Temperature Control and Humidity, Website Abstrak: Telah dilakukan Pengabdian Masyarakat bagi Usaha Mikro Jamur Tiram Putih”Pengendalian suhu dan kelembaban, Benteng Hilir, Deli Serdang. Pengendalian suhu dan kelembaban jamur tiram putih menggunakan sensor suhu DHT 11 berbasis Ardurino Uno R-3 dengan tampilan LCD 16x2 dan HP Android. Pengontrolan suhu dan kelembaban kumbung jamur tiram putih bekerja secara otomatis membantu para petani jamur dalam mengendalikan suhu dan kelembaban kumbung jamur tiram putih.. Jika suhu > 300C dan kelembaban <650C sensor akan membaca suhu dan kelembaban yang berada di kumbung dan mengatur pergerakkan pompa air secara otomatis dan menghidupkan nozzle air dalam penyemprotan air ke bahagian kumbung dan baglog jamur. Alat ini bekerja untuk membantu petani jamur tiram putih dalam peningkatan produksi panennya. Kata Kunci : Pengendalian Suhu dan kelembaban, Website
PEMBELAJARAN TEKNOLOGI KOMPUTER BIDANG PERKANTORAN BAGI PERANGKAT DESA DI KECAMATAN BUNTU PANE
Authors: Irawati Novica , D.E Sinaga Hommy , Siddik Mohd 
Published: February 2021

Abstrak: Computer technology more and more influential in the management of office space at the moment. It is characterized by the more easy it is bureaucracy, the study of grammar of the easy access to information from one point to another. Of course, computer technology will not be such a big contribution to the development of the management of the Government if the role of human resources is not optimized. With respect to the development of computer technology, until now has been a significant development occurred in several areas in regard of the IT application in management offices. Contradictory with the above example, there are still many areas that still have not had the courage or good faith to apply IT in the management of this Office for various reasons. In fact, the IT deployment in government management office management in particular can be a motivation for employees to improve productivity of work.Keywords : Computer technology, management offices, governmentAbstrak: Teknologi Komputer semakin banyak berperan dalam manajemen perkantoran saat ini. Hal ini ditandai dengan semakin mudahnya birokrasi tata persuratan, semakin mudahnya akses informasi dari satu titik ke titik lainnya. Tentu saja, teknologi komputer tidak akan sedemikian besar kontribusinya bagi perkembangan manajemen pemerintahan jika peran sumber daya manusia tidak dioptimalkan. Sehubungan dengan perkembangan teknologi komputer, hingga saat ini telah terjadi perkembangan yang signifikan di beberapa daerah dalam kaitan aplikasi TI dalam Manajemen Perkantoran. Kontradiktif dengan kalimat di atas, masih banyak pula daerah perkantoran didesa yang masih belum memiliki keberanian atau itikad baik untuk mengaplikasikan TI dalam manajemen perkantoran ini dengan berbagai alasan. Padahal, pengaplikasian TI dalam manajemen pemerintahan khususnya manajemen perkantoran dapat menjadi motivasi bagi pegawai untuk meningkatkan produktivitas kerjanya.Kata Kunci: teknologi komputer, manajemen perkantoran, pemerintahan
Adaption and Memory: The Reckless Leader and The Effects of the First Family
Authors: DeWitt Dionnie 
Published: February 2021

There are harmful leaders, but too few instances of how harmful the leadership is within the church get explored and how it affects the first families. Several harmful leadership styles, such as an egotistical leader, an ignorant leader, and a reckless leader, studied in some capacity under leadership. There is an ideology put forward, and it is believed that leaders are not just appearing in business or corporate America, but leaders are leaders and are showing forth their leadership in everyday instances as a mother who teaches their child. The leader's leadership scope was explored by filtering it through adaption and memory, with memory being a significant part of this paper. The overall platform is looking at (reckless) leadership through the lens of religion (Christianity) with a philosophical undertone using personal reflections. The results for this research, under the assumption, of using the qualitative method and using two qualitative designs, helped with data collection. The narrative approach and the phenomenological approach show the leader's evolving behavior and the first family's behavior through personal observation with testimonies to expose the effects of their memory. Scriptures are used to expose or reveal the split leadership dynamic and how memory dictates leaders' response and behavior. Two individual stories were rendered, which more participants are needed to develop a consensus of adaption and memory in leadership and how it affects the first family. Understanding that some things are caught, and some things are taught, this study's outcome, by looking at leadership and the effects of the first family, concluding with the suggestion of furthering this research to explore a more in-depth understanding of reckless leadership in the scope of adaptation to memory.
Demonstração temporal de mortes decorrentes de agressões físicas no Estado do Amazonas
Authors: Ferreira Rúbia Silene Alegre , Sampaio Quézia Correa de Oliveira , Oliveira Aldo Raphael Mota de Oliveira , Matos Geiza Elem Souza de , Monteiro James Barros 
Published: February 2021

Faz-se a demonstração das agressões que resultam em mortes no estado do Amazonas em série histórica, compreendendo o período de 23 anos. Nesta linha de tempo, o foco considera as mortes por faixa etária, escolaridade, estado civil e por local de ocorrência. Os dados são oriundos do Sistema de Informações sobre Mortalidade – SIM do DATASUS/MS, com início em 1996, finalizando em 2019. Os resultados sinalizam que dos sete grupos estudados, tanto para homens quanto para mulheres, três destes são os que se destacam com os maiores eventos: 15 a 19; 20 a 29 e 30 a 39 anos. À medida que a escolaridade se eleva, as mortes decorrentes de agressão são menores e o estado civil embora apresente-se com maiores casos para os solteiros, não é garantia de isenção nestas fatalidades. O local das mortes aponta que boa parte destas se dá em vias públicas e em hospitais para as mulheres, com relativa representatividade de óbitos em domicílio. Para os homens, a maioria absoluta se manifesta em hospital, com eventos muito próximos em via pública e nos domicílios, porém em escalas menores. Assim, a violência ainda é uma das mazelas mais graves que acompanham humanidade, mas que carece de ações de enfrentamento e tratativa.
The Effects of Repeat-Dose Doxorubicin on Cardiovascular Functional Endpoints and Biomarkers in the Telemetry-Equipped Cynomolgus Monkey
Authors: Engwall Michael J. , Everds Nancy , Turk James R. , Vargas Hugo M. 
Published: February 2021

Purpose: Doxorubicin-related heart failure has been recognized as a serious complication of cancer chemotherapy. This paper describes a cardiovascular safety pharmacology study with chronic dosing of doxorubicin in a non-human primate model designed to characterize the onset and magnitude of left ventricular dysfunction (LVD) using invasive and non-invasive methods.Methods: Cynomolgus monkeys (N = 12) were given repeated intravenous injections of doxorubicin over 135 days (19 weeks) with dosing holidays when there was evidence of significantly decreased hematopoiesis; a separate group (N = 12) received vehicle. Arterial and left ventricular pressure telemetry and cardiac imaging by echocardiography allowed regular hemodynamic assessments and determination of LVD. Blood samples were collected for hematology, clinical chemistry, and assessment of cardiac troponin (cTnI) and N-terminal pro b-type natriuretic peptide (NT-proBNP). Myocardial histopathology was a terminal endpoint.Results: There was variable sensitivity to the onset of treatment effects, for example 25% of doxorubicin-treated animals exhibited LVD (e.g., decreases in ejection fraction) following 50–63 days (cumulative dose: 8–9 mg/kg) on study. All animals deteriorated into heart failure with additional dosing 135 days (total cumulative dose: 11–17 mg/kg). Reductions in arterial pressure and cardiac contractility, as well as QTc interval prolongation, was evident following doxorubicin-treatment. Both cTnI and NT-proBNP were inconsistently higher at the end of the study in animals with LVD. Measurements collected from control animals were consistent and stable over the same time frame. Minimal to mild, multifocal, vacuolar degeneration of cardiomyocytes was observed in 7 of 12 animals receiving doxorubicin and 0 of 12 animals receiving vehicle.Conclusions: This repeat-dose study of doxorubicin treatment in the cynomolgus monkey demonstrated a clinically relevant pattern of progressive heart failure. Importantly, the study revealed how both telemetry and non-invasive echocardiography measurements could track the gradual onset of LVD.
Routine Echocardiography and Artificial Intelligence Solutions
Authors: Schuuring Mark J. , Išgum Ivana , Cosyns Bernard , Chamuleau Steven A. J. , Bouma Berto J. 
Published: February 2021

Introduction: Echocardiography is widely used because of its portability, high temporal resolution, absence of radiation, and due to the low-costs. Over the past years, echocardiography has been recommended by the European Society of Cardiology in most cardiac diseases for both diagnostic and prognostic purposes. These recommendations have led to an increase in number of performed studies each requiring diligent processing and reviewing. The standard work pattern of image analysis including quantification and reporting has become highly resource intensive and time consuming. Existence of a large number of datasets with digital echocardiography images and recent advent of AI technology have created an environment in which artificial intelligence (AI) solutions can be developed successfully to automate current manual workflow.Methods and Results: We report on published AI solutions for echocardiography analysis on methods' performance, characteristics of the used data and imaged population. Contemporary AI applications are available for automation and advent in the image acquisition, analysis, reporting and education. AI solutions have been developed for both diagnostic and predictive tasks in echocardiography. Left ventricular function assessment and quantification have been most often performed. Performance of automated image view classification, image quality enhancement, cardiac function assessment, disease classification, and cardiac event prediction was overall good but most studies lack external evaluation.Conclusion: Contemporary AI solutions for image acquisition, analysis, reporting and education are developed for relevant tasks with promising performance. In the future major benefit of AI in echocardiography is expected from improvements in automated analysis and interpretation to reduce workload and improve clinical outcome. Some of the challenges have yet to be overcome, however, none of them are insurmountable.
Endothelin-1 Upregulates Activin Receptor-Like Kinase-1 Expression via Gi/RhoA/Sp-1/Rho Kinase Pathways in Human Pulmonary Arterial Endothelial Cells
Authors: Sugimoto Koichi , Yokokawa Tetsuro , Misaka Tomofumi , Kaneshiro Takashi , Yamada Shinya , Yoshihisa Akiomi , Nakazato Kazuhiko , Takeishi Yasuchika 
Published: February 2021

Background: Pulmonary arterial hypertension (PAH) is characterized by pulmonary vasoconstriction and organic stenosis. It has been demonstrated that endothelin-1 (ET-1) induces pulmonary vasoconstriction through the activation of RhoA. In addition, a gene mutation of activin receptor-like kinase (ACVRL)-1 is recognized in PAH patients. However, little is known about the association between ET-1 and ACVRL-1.Objective: In the present study, we aimed to investigate the effect of ET-1 on ACVRL-1 expression and delineate the involvement of the Gi/RhoA/Rho kinase pathway.Methods: ET-1 was added to culture medium of human pulmonary arterial endothelial cells (PAECs). Pre-treatment with pertussis toxin (PTX) or exoenzyme C3 transferase (C3T) was performed for inhibition of Gi or RhoA, respectively. Rho kinase was inhibited by Y27632. Mithramycin A was used for inhibition of Sp-1, which is a transcriptional factor of ACVRL-1. The active form of RhoA (GTP-RhoA) was assessed by pull-down assay.Results: ACVRL-1 expression was increased by ET-1 in the PAECs. Pull-down assay revealed that ET-1 induced GTP-loading of RhoA, which was suppressed by pre-treatment with PTX or C3T. Further, PTX, C3T, and Y27632 suppressed the ET-1-induced ACVRL-1 expression. ET-1 increased the activity of the ACVRL-1 promoter and stabilized the ACVRL-1 mRNA. Sp-1 peaked 15 min after adding ET-1 to the PAECs. PTX and C3T prevented the increase of Sp-1 induced by ET-1. Inhibition of Sp-1 by mithramycin A suppressed ET-1-induced ACVRL-1 upregulation.Conclusion: The present study demonstrated that ET-1 increases ACVRL-1 expression in human PAECs via the Gi/RhoA/Rho kinase pathway with the involvement of Sp-1.
Controls on Gas Emission Distribution on the Continental Slope of the Western Black Sea
Authors: Riedel Michael , Hähnel Line , Bialas Jörg , Bachmann Anna Katharina , Gaide Stefanie , Wintersteller Paul , Klaucke Ingo , Bohrmann Gerhard 
Published: February 2021

The continental slopes of the Black Sea show abundant manifestations of gas seepage in water depth of &lt;720 m, but underlying controls are still not fully understood. Here, we investigate gas seepage along the Bulgarian and Romanian Black Sea margin using acoustic multibeam water column, bathymetry, backscatter, and sub-bottom profiler data to determine linkages between sub-seafloor structures, seafloor gas seeps, and gas discharge into the water column. More than 10,000 seepage sites over an area of ∼3,000 km2were identified. The maximum water depth of gas seepage is controlled by the onset of the structure I gas hydrate stability zone in ∼720 m depth. However, gas seepage is not randomly distributed elsewhere. We classify three factors controlling on gas seepage locations into depositional, erosional, and tectonic factors. Depositional factors are associated with regionally occurring sediment waves forming focusing effects and mass-transport deposits (MTDs) with limited sediment drape. Elongated seafloor depressions linked to faulting and gas seepage develop at the base between adjacent sediment waves. The elongated depressions become progressively wider and deeper toward shallow water depths and culminate in some locations into clusters of pockmarks. MTDs cover larger regions and level out paleo-topography. Their surface morphology results in fault-like deformation patterns of the sediment drape on top of the MTDs that is locally utilized for gas migration. Erosional factors are seen along channels and canyons as well as slope failures, where gas discharge occurs along head-scarps and ridges. Sediment that was removed by slope failures cover larger regions down-slope. Those regions are devoid of gas seepage either by forming impermeable barriers to gas migration or by removal of the formerly gas-rich sediments. Deep-rooted tectonic control on gas migration is seen in the eastern study region with wide-spread normal faulting promoting gas migration. Overall, gas seepage is widespread along the margin. Gas migration appears more vigorous in shallow waters below ∼160 m water depth, but the number of flare sites is not necessarily an indicator of the total volume of gas released.
Treatment of Chronic Venous Ulcers With Heterologous Fibrin Sealant: A Phase I/II Clinical Trial
Authors: Abbade Luciana P. F. , Barraviera Silvia Regina Catharino Sartori , Silvares Maria Regina Cavariani , Lima Ana Beatriz B. de C. O. , Haddad Gabriela R. , Gatti Márcia A. N. , Medolago Natália Bronzatto , Rigotto Carneiro Márcia Tonin , dos Santos Lucilene Delazari , Ferreira Rui Seabra , Barraviera Benedito 
Published: February 2021

BackgroundHeterologous fibrin sealant (HFS) consists of a fibrinogen-rich cryoprecipitate extracted from Bubalus bubalis buffalo blood and a thrombin-like enzyme purified from Crotalus durissus terrificus snake venom. This study evaluated the safety and immunogenicity of HFS, estimated the best dose, and assessed its preliminary efficacy in the treatment of chronic venous ulcers (CVU).MethodsA phase I/II non-randomized, single-arm clinical trial was performed on 31 participants, accounting for a total of 69 active CVUs. All ulcers were treated with HFS, essential fatty acid, and Unna boot for 12 weeks. The outcomes assessed were: (1) primary safety, immunogenicity analyses, and confirmation of the lowest safe dose; (2) secondary promising efficacy by analyzing the healing process. Immunogenicity was evaluated using the serum-neutralizing (IgM and IgG) and non-neutralizing (IgA and IgE) antibody techniques against the product. The immuno-detection of IgE class antibodies was assessed using dot-blot assay before and at the end of treatment. Positive samples on dot-blot assays were subsequently analyzed by western blotting to verify the results.ResultsNo severe systemic adverse events related to the use of HFS were observed. Local adverse events potentially related to treatment include ulcer pain (52%), peri-ulcer maceration (16%), peri-ulcer pruritus (12%), critical colonization (8%), peri-ulcer eczema (4%), the opening of new ulcers (4%), and increased ulcerated area 4%). Neutralizing and non-neutralizing antibodies did not show significant deviations at any of the evaluated time points. Blot assays showed that all patients presented negative immunological reactions, either before or after treatment, with the thrombin-like enzyme component. In addition, two participants showed a positive immunological reaction to the cryoprecipitate component, while another two were positive before and during treatment. Regarding the secondary outcomes of preliminary efficacy, a total healing and significant reduction of the area was observed in 47.5 and 22%, respectively. A qualitative improvement was observed in the wound beds of unhealed ulcers.ConclusionsThe investigational HFS bioproduct proved to be safe and non-immunogenic with a good preliminary efficacy for the treatment of CVU, according to the protocol and doses proposed. A multicentric phase III clinical trial will be necessary to verify these findings.