bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective evaluation of probabilistic dose-escalated IMRT in prostate cancer
Authors: Wegener Daniel , Berger Bernhard , Outtagarts Zhoulika , Zips Daniel , Paulsen Frank , Bleif Martin , Thorwarth Daniela , Alber Markus , Dohm Oliver , Müller Arndt-Christian 
Published: January 2021

Abstract

Background
Cure- and toxicity rates after intensity-modulated radiotherapy (IMRT) of prostate cancer are dose-and volume dependent. We prospectively studied the potential for organ at risk (OAR) sparing and compensation of tumor movement with the coverage probability (CovP) concept.

Patients and methods
Twenty-eight prostate cancer patients (median age 70) with localized disease (cT1c–2c, N0, M0) and intermediate risk features (prostate-specific antigen [PSA] < 20, Gleason score ≤ 7b) were treated in a prospective study with the CovP concept. Planning-CTs were performed on three subsequent days to capture form changes and movement of prostate and OARs. The clinical target volume (CTV) prostate and the OARs (bladder and rectum) were contoured in each CT. The union of CTV1–3 was encompassed by an isotropic margin of 7 mm to define the internal target volume (ITV). Dose prescription/escalation depended on coverage of all CTVs within the ITV. IMRT was given in 39 fractions to 78 Gy using the Monte-Carlo algorithm. Short-term androgen deprivation was recommended and given in 78.6% of patients.

Results
Long-term toxicity was evaluated in 26/28 patients after a median follow-up of 7.1 years. At last follow-up, late bladder toxicity (Radiation Therapy Oncology Group, RTOG) G1 was observed in 14.3% of patients and late rectal toxicities (RTOG) of G1 (7.1%) and of G2 (3.6%) were observed. No higher graded toxicity occurred. After 7.1 years, biochemical control (biochemically no evidence of disease, bNED) was 95.5%, prostate cancer-specific survival and the distant metastasis-free survival after 7.1 years were 100% each.

Conclusions
CovP-based IMRT was feasible in a clinical study. Dose escalation with the CovP concept was associated by a low rate of toxicity and a high efficacy regarding local and distant control.
Estimation of the impact of migraine on self-rated health: A cross-sectional study in Slovenia
Authors: Popit Matjaž , Zaletel-Kragelj Lijana , Eržen Ivan , Zadravec-Zaletel Lorna , Zaletel Marjan 
Published: January 2021

Abstract

Aim
With the aim of providing a foundation for evidence-based public health actions, as well as the more individualised clinical treatment of migraine in Slovenia, the objective of our study was to assess the association between poor self-rated health (PSRH) and migraine, adjusted for selected comorbidity and socioeconomic factors.

Methods
The survey, conducted between August and December 2014, involved included 6,262 adults aged 15 years and over. Binary logistic regression was used in univariate as well as multivariate analysis. Three multivariate models were defined: MODEL 1 (migraine and comorbidities related to the physical dimension of health); MODEL 2 (comorbidities related to the mental dimension of health); MODEL 3 (demographic and socioeconomic factors).

Results
In univariate as well as all three multivariate models, the odds of PSRH were statistically significantly higher in migraine sufferers in comparison to non-sufferers (univariate model: ORmigraine=yes vs. migraine=no=2.22 (p<0.001); MODEL 1: ORmigraine=yes vs. migraine=no=2.27 (p<0.001); MODEL 2: ORmigraine=yes vs. migraine=no=1.51 (p=0.002); MODEL 3: ORmigraine=yes vs. migraine=no=1.56 (p=0.001)).

Conclusion
Migraine is an important PSRH-related factor. Comorbidities related to the physical dimension of health do not reduce the power of association between migraine and PRSH, while comorbidities related to the mental dimension reduce the power of association of migraine and other health conditions. The power of the association between migraine and PRSH is also independent of demographic/socioeconomic factors. We can also conclude that migraine seems to be a phenomenon that is in a bi-directional relationship with mental states (thus having an impact on PSRH) and is itself a stressor.
On Extremal Problems for Pairs of Uniformly Distributed Sequences and Integrals with Respect to Copula Measures
Authors: Durante Fabrizio , Fernández-Sánchez Juan , Ignazzi Claudio , Trutschnig Wolfgang 
Published: January 2021

Abstract
Motivated by the maximal average distance of uniformly distributed sequences we consider some extremal problems for functionals of type

μ

C

↦

∫
0
1

∫
0
1

F
d

μ

C

,

{\mu _C} \mapsto \int_0^1 {{{\int_0^1 {Fd} }_\mu }_C,}

where µC
is a copula measure and F is a Riemann integrable function on [0, 1]2 of a specific type. Such problems have been considered in [4] and are of interest in the study of limit points of two uniformly distributed sequences.
Urgent surgical department in multidisciplinary hospital repurposed as infectious hospital for new coronavirus infection (COVID-19)
Authors: Korolkov A. Yu. , Teplov V. M. , Zaitsev D. A. , Tcebrovskaya E. A. , Nikitina T. O. 
Published: January 2021

Objective. In this paper, we show the work of the emergency surgical department on the example of a large repurposed multidisciplinary hospital, also its necessity even for infectious hospitals not accepting patients with acute surgical pathology.Methods and Materials. The work of surgical department of Pavlov First Saint Petersburg State Medical University repurposed for COVID-19 patients was analyzed. About 1500 COVID-19 patients were hospitalized during 4-month period.Results. All patients undergoing surgery were in severe condition (at intensive care unit). Most common surgery in abdomen was diagnostic laparoscopy. Spontaneous bleedings of different localization occurred in these patients, what required endovascular and endoscopic treatment. We observed only Clavien – Dindo 1-degree postoperative complications. Mortality rate was high and amounted to 75 %.Conclusion. The work of surgical department in an infectious hospital for the treatment of a new coronavirus infection is extremely difficult. An infectious hospital should have a 24-hour diagnostic service (US, CT, MRI). Patients severity and the working conditions necessitate the availability of the trained surgical personnel. Given the high risks of bleedings in patients with COVID-19, it is necessary to have a 24-hour endoscopy and endovascular surgery departments with the ability to perform diagnostic and therapeutic interventions.
Predicting for mortality rate using regression analysis in patient with burn injury
Authors: Zavorotniy O. O. , Zinoviev E. V. , Kostyakov D. V. 
Published: January 2021

The objective was to develop a methodology for predicting death in patients with burn injury using regression analysis methods.Methods and Materials. The analysis of the results of treatment of 330 burned with a shock injury, hospitalized in the Department of Anesthesiology and Resuscitation of the Department of Thermal Lesions of Saint-Petersburg I. I. Dzhanelidze research institute of emergency medicine in the period 2013–2019.Results. In the course of the study, 52 indicators were identified that characterized the condition of the victim with burn injury in the dynamics of treatment measures. To build a predictive model, only statistically significant parameters (p<0.05) were used, which were used to build a model of logistic regression. The final algorithm included 18 predictors. The model allows predicting a positive outcome of treatment and the likelihood of a fatal outcome with an accuracy of 93 and 87 % respectively.Conclusion. The use of a multivariate mathematical model made it possible to develop a method for predicting a fatal outcome, taking into account the peculiarities of the pathogenesis of burn disease and the principles of therapeutic measures in the first three days after injury. The use of linear regression analysis using new indicators of thermal injury in a retrospective cohort of 330 patients allowed us to achieve a high predictive value.
Necrosis and perforation of the stomach in newborn babies and infants
Authors: Karavaeva S. A. , Podkamenev A. V. , Skopetc A. A. 
Published: January 2021

The Objective of the study was to identify the clinical features of newborns and infants with perforation of the stomach, and to justify the possibility of organ-preserving operations even with extensive gastric necrosis.Methods and Materials. The results of treatment of 32 newborns with stomach perforation was analyzed: not only the risk factors that cause this condition, but diagnostic methods and variants of surgical treatment. All patients with extensive necrosis of the stomach wall underwent an atypical resection within healthy tissues, a gastric «tube» was formed on the drainage probe with a significant decrease of organ volume. In cases of the local damage of the gastric wall, the perforated area was sutured after the excision of the edges of the defect.Results. Mortality rate was 36.5 % (n = 12). The cause of death in 5 children (15 %), in 3 to 8 days after surgery, was multiple organ failure syndrome. In 7 patients (22 %), a fatal outcome occurred due to the severe post-intensive care syndrome at the age of 3 to 12 months of life.Conclusion. The mechanism of perforations of the stomach in newborns and infants is multifactorial. All children with stomach perforation need preoperative preparation. The operation of choice for the stomach perforation is an organpreserving surgery. The function of the stomach is restored in all children after extensive resection of the stomach.
Features of the clinic in patients with non-tumor mechanical jaundice with concomitant pathology
Authors: Fedorov V. E. , Kharitonov B. S. , Maslyakov V. V. , Aslanov A. D. , Logvina O. E. , Narizhnaya M. A. 
Published: January 2021

The Objective was to improve the results of diagnostics of the severity of patients with complications of cholelithiasis, occurring in the form of mechanical jaundice, against the background of comorbidity.Methods and Materials. 537 patients admitted in the clinic of hospital surgery of Kabardino-Balkar State University named after H. M. Berbekov in the period from 2010 to 2019 were examined. The terms of admission to the hospital were different. 25 (4.6 %) people were admitted in a short period of time up to 6 hours. A day after the onset of the disease – 82 (15.3 %) people. More than half – 277 (51.6 %) people were hospitalized a week after the onset of the disease. We analyzed the data of comorbidity scales of CIRS, Kaplan–Feinstein and Mary Charlson Index, as well as biochemical criteria reflecting the severity of calculous cholecystitis, jaundice and concomitant diseases.Results. As a result of their analysis and comparison, we found that comorbidity in patients of this kind is the main aggravating factor and worsens the пeneral condition as the stages of jaundice develop.Conclusion. We found out that a common biochemical tests as for characterizing changes of the hepatocyte in nontumor obstructive jaundice, and for evaluating the degree of impact of comorbidity are the content of blood alkaline phosphatase, creatine phosphokinase and transaminases. Intoxication syndrome in patients with cholangitis and comorbidity so negatively affect all organs and systems of the body that it can lead to inoperability.
Lung cancer and aortic stenosis: one-stage surgical treatment
Authors: Pechetov A. A. , Alekyan B. G. , Lednev A. N. , Makov M. A. , Karapetyan N. G. , Gelecyan L. G. 
Published: January 2021

Surgical treatment of oncological diseases with concomitant somatic pathologies is a complex issue. In situations when concomitant somatic pathology also requires a surgical approach, the determination of adequate treatment tactics is most relevant. Delayed surgical treatment of cancer increases the risks of progression and generalization of the process; surgical treatment of a tumor against the background of decompensated concomitant pathology potentially entails risks of an unfavorable outcome. With a combination of oncological and somatic diseases, the definition of treatment algorithms today is one of the primary tasks.This paper presents a clinical observation of one-stage surgical treatment of lung cancer and severe aortic stenosis, provides a brief literature review on this topic.
¿De quién es la culpa? Reflexiones en torno al malestar del sujeto neoliberal durante la pandemia del Covid-19 en Chile y sus implicancias para el trabajo clínico psicoanalítico
Authors: Revuelto Luis Felipe , Ulloa Diego 
Published: January 2021

A propósito de la pandemia del Covid-19 en Chile, este texto busca elaborar una reflexión sobre el abordaje estatal de la emergencia sanitaria y los fenómenos asociados a esta, identificando como un elemento común de estas medidas: la responsabilización individual de los sujetos respecto de su malestar. El texto propone mostrar un breve recorrido de los hechos, medidas y resoluciones que el contexto supuso, para entenderlas en su conjunto a partir de cierta forma específica de subjetivación en Chile, a saber: la del neoliberalismo.
Los procesos de subjetivación suponen cierta forma de gobierno que concibe a la ciudadanía como personas libres y responsables de administrar y triunfar (o no) en su vida. A raíz de esto, se busca tensionar la noción de responsabilidad subjetiva y sus implicancias en la clínica psicoanalítica a partir de la lectura de Jacques Lacan, proponiendo que el sujeto del inconsciente se diferencia del individuo, en este caso, de la subjetivación.
--
About the Covid-19 pandemic in Chile, this text seeks to elaborate a reflexion about the state approach to the sanitary emergency and the phenomena associated with this, identifying as a common element of these measures: the individual responsibility of the subjects regarding their discomfort. The text proposes to show a brief overview of the events, measures and resolutions that context supposed to understand them as a whole from a certain specific form of subjectivation in Chile, namely: that of neoliberalism.
The processes of subjectivation involve a certain form of government that conceives citizens as free people and responsible for administrating and succeeding (or not) in their lives. As a result of this, it seeks to tense the notion of subjective responsibility and its implications in the psychoanalytic clinic from the reading of Jacques Lacan, proposing that the subject of the unconscious differs from the individual, in this case, from the subjectivation.
Notas sobre el pragmatismo de Erving Goffman y su concepto de estigma
Authors: Torres López Tomás 
Published: January 2021

El presente artículo trata las influencias del pragmatismo en el concepto de Estigma de Erving Goffman. El objetivo principal es develar el influjo de la corriente filosófica norteamericana en la configuración de uno de los conceptos más importantes de este sociólogo canadiense. Para ello, el texto aborda algunos de los postulados más destacados de G.H. Mead y de la Escuela de Chicago, particularmente de algunos de los exponentes del Interaccionismo simbólico. En términos metodológicos, se realizó una revisión hermenéutica de los textos más relevantes de los autores analizados en miras de hallar en ellos los conceptos que permitan construir un puente de diálogo entre perspectivas. En la parte final del texto, se puede apreciar que el pragmatismo no es sólo un elemento secundario en la obra de Goffman, sino que se encuentra en el centro de la configuración del concepto de estigma.
--
This essay treats the influence of the pragmatism on the concept of stigma from Erving Goffman. The main objective is to show the influx of this philosophical perspective in the configuration of one of the mains aspects of this Canadian sociologist. For that, the texts aboard some of the proposition of G. H. Mead and the Chicago School, specifically some of the most important exponents from the last. In methodological terms I made a hermeneutic revision of the most relevant texts of this author to find in them some concepts that allow build a dialogue bridge between these perspectives. In the final part of this essay, we can appreciate that the pragmatism is not a secondary element of Goffman`s oeuvres but is one of the most important in the configuration of stigma concept.
La devastación neoliberal. El virus como síntoma
Authors: Villalobos-Ruminott Sergio 
Published: January 2021

El presente texto intenta una lectura de la crisis sanitaria abierta con la propagación del COVID-19 y su relación con los procesos de desregulación económica y política asociadas con el giro neoliberal contemporáneo. A partir de interrogar las transformaciones en los procesos de acumulación, apropiación y valoración, el texto muestra la propagación de enfermedades zonóticas como consecuencia de la flexibilización de los mecanismos regulatorios propios del capitalismo moderno, cuestión que genera, por un lado, una trasformación general de las relaciones de poder y explotación, mientras que por otro lado, demanda una consideración sobre la singularidad de las prácticas sociales de resistencia y, finalmente, sobre la misma cuestión de la política en el contexto actual. Haciendo uso de la noción de derrame acuñada por Gilles Deleuze, se muestra la lógica proliferante tanto del virus como del capital, más allá de las nociones generales propias de la teoría social moderna.
--
The following text attempts a reading of the current crisis opened by COVID-19 and its proliferation in relationship with the economic and political processes of deregulation that characterize contemporary neoliberalism. By interrogating the ongoing transformation within the practices of accumulation, appropriation, and valuation, the article shows the propagation of zoonotic diseases as a logical consequence of the flexibilization of modern capitalism’s regulatory mechanisms. This flexibilization, in turn, generates, on the one hand, a general change on the power and exploitation social relations, while, on the other hand, demands from us a rigorous consideration regarding the singularity of contemporary social practices of resistance and the question of politics at large. By referring to Gilles Deleuze’s notion of spillover (or deterritorialization), the text points toward the proliferating logic of both virus and capital, beyond the too-general notions the fed modern social theory.
Being Muslim Immigrants in America: Preservation, Resistance, and Negotiation of Identity in Ayad Akhtar’s “American Dervish”
Authors: Handayani Rika 
Published: January 2021

This thesis entitled ‘Being Muslim Immigrants in America: Preservation, Resistance, and Negotiation of Identity in Ayad Akhtar’s ‘American Dervish’ aims to analyze the depiction of Muslim immigrants identity in the context of diaspora. Through the lenses of Hall’s theory of identity and Clifford’s diaspora, the analysis centered on how the Muslim immigrant characters in the novel interacted with other individuals with diverse backgrounds of race, gender, and religion. This contributed towards the construction of identity through the preservation and resistance of homeland culture, dominant culture or host land culture and the negotiation between Muslim immigrants and their state and American society. Therefore, the Muslim immigrant characters in the novel hold a non-essential and fluid identity as portrayed from the perpetual construction of identity.
Pragmatics Analysis of Presupposition as Found in The Tagline of Horror Movie Posters
Authors: Roza Yelmi , Ayumi Ayumi 
Published: January 2021

This research is about pragmatics analysis of presupposition as found in the tagline of horror movie posters. This research aimed to discover presupposition triggers and type of presupposition in the tagline of horror movie posters. In this research, the data were collected by downloading 14 taglines in horror movie posters. Then, the data downloaded were divided according to the presupposition triggers and the types of presuppositions. The data were analyzed using two theories, presupposition triggers by Kartunnen (1973) and Yule’s presupposition types (1996). The result of the analysis shows an argument and a table. The results show that from 42 presupposition triggers found in the tagline of horror movie posters, definite descriptions are the most dominant presupposition triggers. Other presupposition triggers are the change of state verbs, factive verb, and counterfactual conditional. Meanwhile, out of 6 types of presuppositions, there are only four types of presuppositions found in the tagline of horror movie posters: existential presupposition, lexical presupposition, factive presupposition, and counterfactual presupposition.
Inovasi Administrasi Perpajakan Dalam Optimalisasi Peneriamaan Pajak Daerah (Studi Pemasangan Tapping Box Pada Pajak Hotel, Restoran Dan Hiburan Di Kota Kendari)
Authors: Firdaus Firdaus 
Published: January 2021

Penelitian ini bertujuan untuk mengeksplorasi inovasi administrasi perpajakan dengan melihat pengeloiaan sumber daya manusia perpajakan yang produktif. Hasil penelitian ini menunjukan bahwa Pemerintah Kota Kendari telah membentuk kerjasama melalui Nota Kesepahaman (Memorandum of Unsderstanding) dengan Komisi Pemberantasan Korupsi (KPK) pada Bidang Koordinasi, Supervisi dan Pencegahan (Korsubgah) dan Bank Sultra. Salah satu kesepakatan yang dibangun adalah kerjasama pemasangan alat perekam pajak (tapping box) pada usaha perhotelam, restoran dan hiburan. Legalitas penerapan alat transaksi pajak ini diatur dalam Peraturan Walikota Kendari Nomor 24 Tahun 2019 tentang Pembayaran dan Pemungutan Pajak dan Retribusi Daerah secara Sistem Online melalui Alat Perekam Pajak. Penerapan tapping box memberikan dampak yang sangat positif terhadap besaran jumlah penerimaan daerah dibandingkan dengan sebelum adanya pemasangan alat tersebut. Hal ini terliha pada penerimaan pajak hotel tahun 2018 sebesar Rp. 8,76 miliar meningkat menjadi Rp. 12,7 miliar pada tahun 2019. Penerimaan pajak restoran tahun 2018 sebesar Rp. 11,2 miliar menjadi Rp. 16 miliar meningkat pada tahun 2019. Kemudian penerimaan pajak hiburan pada tahun 2018 sebesar Rp. 7,2 miliar meningkat menjadi Rp. 8,5 miliar pada tahun 2019. Jumlah pemasangan tapping box di Kota Kendari juga meningkat yang awalnya 76 unit menjadi 464 unit hingga Oktober tahun 2020. Maka dari itu, perlu meningkatkan kerjasama dari berbagai pihak dalam menyelenggarakan program penerapan tapping box untuk mengoptimalkan penerimaan pajak hotel, restoran dan hiburan supaya terciptanya efektifitas dan efisiensi dalam sebuah inovasi dalam administrasi perpajakan untuk membangun sumber daya manusia perpajakan yang produktif dan berbasis digital.
Kuşak-Yol Projesi ve Türkiye Üzerine Etkileri
Authors: ÇAKILCI Ulaş Birkan 
Published: January 2021

Coğrafi keşifler ile birlikte önemini yitiren tarihi İpek Yolu'nun modernize edilmiş hali olarak sunulan ve Çin Devlet Başkanı Xi Jinping'in 2013 yılındaki açıklamasıyla ortaya çıkan Kuşak-Yol İnisiyatifi, hem karada hem denizde oluşturduğu güzergahları ile oldukça büyük bir etki alanına sahiptir. İnisiyatif, katılımcı ülkelere ekonomik, toplumsal ve kültürel yönden çeşitli avantajlar sunmaktadır ve Türkiye de başından beri inisiyatife katılmış bir Orta Koridor ülkesidir. Bu çalışmada da öncelikle Kuşak-Yol`un tarihine, proje finansmanlarına, güzergah kollarının neler olduğuna ve proje ile ilgili güvenlik endişelerine yer verilmiştir. Devamında Kuşak-Yol projesinin amacının ne olduğu ve katılımcı diğer ülkeler ile Türkiye açısından avantaj ve dezavantajları tartışılmıştır. Nihayetinde de elde edilen bulgular ışığında dış politika ile ilişkilendirip bir takım öneriler sunularak makale sonlandırılmıştır.