bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic assessment of quaternary ammonium compounds for the potential to elicit developmental and reproductive effects
Authors: DeSesso John M. , Harris Stephen B. , Scialli Anthony R. , Williams Amy Lavin 
Published: October 2021

AbstractIntroductionQuaternary ammonium compounds (QUATs) are commonly found in cleaning products, disinfectants, hand sanitizers, and personal care products. They have been used for >50 years and are considered safe when used according to directions. Recent papers report reduced fertility and neural tube defects in rodents after low‐level exposures. To determine if QUATs interfere with mammalian reproduction and development, we conducted a methodical assessment of all available data.MethodsA systematic literature search identified 789 potential articles. Review of titles and abstracts found eight relevant studies, including two dissertation chapters; to these, 10 unpublished, guideline‐compliant developmental and reproductive toxicity (DART) studies of QUATs (alkyldimethylbenzylammonium chloride [ADBAC] and dialkyldimethylammonium chloride [DDAC]) were added. ToxRTool was utilized to evaluate all 18 studies for data quality.ResultsSix studies were scored as “reliable without restriction”; four studies were considered “reliable with restriction” (mainly due to small rabbit group sizes). No test article‐related, adverse DART endpoints were reported in these studies. ToxRTool scored the remaining eight studies as “not reliable.” The unreliable studies failed to fully describe methods and/or endpoints, did not quantify (and in some cases, did not verify) exposures, utilized non‐standard test methods, reported endpoints incorrectly, and assessed endpoints at inappropriate times.Some (not all) unreliable studies reported adverse effects after 7.5 mg QUATs/kg/day (mice), but these results were inconsistent. The reliable studies tested exposures ≥100 mg/kg/day (rats) with no effects.ConclusionsThe available weight of evidence indicates no adverse DART effects after QUATs exposures at anticipated concentrations and normal use.
Impact ofCOVID‐19 on consumers' impulse buying behavior of fitness products: A moderated mediation model
Authors: Chiu Weisheng , (Grace) Oh Ga‐Eun , Cho Heetae 
Published: October 2021

AbstractDuring the COVID‐19 pandemic, consumers are found to be more impulsive to purchase fitness products online. Accordingly, the purpose of this study was to investigate a moderated mediation model of consumers' perception of COVID‐19 and impulse buying behavior through fear moderated by income. A total of 608 responses were collected from consumers in the United States, and this study employed partial least squares structural equation modeling (PLS‐SEM) to examine the hypothesized relationships in the research model. The results showed that the perception of COVID‐19 had a positive influence on fear, which in turn led to impulse buying behavior of fitness products. Moreover, consumers' income levels negatively moderated the positive relationship between fear and impulse buying behavior. The findings contribute to a better understanding of consumers' behavior and offer practical implications that enable marketers and retailers to predict consumers' behavior during the COVID‐19 pandemic.
Shortening of Palmaz Genesis XD stents by longitudinal compression in pediatric patients with pulmonary vein stenosis: Bench‐testing and case series
Authors: Webb Melissa K. , Justino Henri 
Published: October 2021

AbstractThe Palmaz Genesis XD stents (Cordis®, Cardinal Health, Dublin, OH) are an ideal option for stenting vessels in pediatric patients due to their ability to be re‐dilated to large diameters to accompany children's somatic growth. Unfortunately, their length limits their utility for pulmonary vein stenting in small children, due to the risk of protrusion into the left atrium or into distal pulmonary vein branches. We describe a stent shortening technique by longitudinally compressing them prior to deployment, which may enhance their applicability in pediatric pulmonary vein stenosis.
Trait associations and genetic variability in field pea (Pisum sativum L.): Implications in variety development process
Authors: Daba Sintayehu D. , McGee Rebecca J. , Morris Craig F. 
Published: October 2021

AbstractBackground and objectivesResearch and breeding for pea protein extraction are likely to play an important role as the demand for pea protein increases. Developing pea cultivars with high protein concentration could be a top breeding priority. Identification of the traits to select for and understanding the relationships between them will optimize the breeding process. Protein was extracted from 26 green and 30 yellow pea genotypes grown in four and two environments, respectively.FindingsDuring dehulling/decortication, approximately 15.6% of the pea seed was removed as seed coat, with a low of 10.1% and a high of 20.4%. The protein concentration of split pea flour varied between 18.9% and 29.3%. Split pea had 1.4 percentage point higher protein than the whole pea. Flour protein concentration varied among environments, with Fairfield, WA having the highest mean values. Protein isolate yield ranged from 14.8% to 21.1%, with a mean of 17.8%. Protein recovery from split pea flour ranged from 57.4% to 76.3% across all pea types, with a mean of 65.7%. On average, about 61.6% of the initial sample ended up in the starch‐rich byproduct fraction. The remaining 20.6% the initial samples lost as soluble material during the extraction process. Correlation analysis indicated that flour protein concentration was positively correlated with protein isolate yield and purity but negatively with yield of the starch‐rich byproduct.ConclusionsIncreasing protein concentration leads to increased protein yield and reduced the loss as byproduct during the extraction process. Further studies are required to understand the relationships of protein isolate yield and purity with functional properties of protein.Significance and noveltyThe associations among traits imply that the flour protein concentration could be used in the selection process. Increasing protein concentration could be one key input in proving pea cultivars for protein isolation.
Minimal change nephrotic syndrome four days after the administration of Pfizer‐BioNTech COVID‐19 vaccine—a new side effect or coincidence?
Authors: Abdulgayoom Mohammed , Albuni Mhd Kutaiba , Abdelmahmuod Elabbass , Murshed Khaled , Eldeeb Yassir 
Published: October 2021

AbstractThe association between the COVID vaccine and MCD is temporal and by exclusion, and it is not fully established, but it should be considered in postvvaccine MCD.
Relation Between Coordination and Lewis‐Acid Property of MOF‐Derived Mononuclear Zn(II) Catalyst Toward Epoxide Hydroxylation
Authors: Xiao Juan‐Ding , Lu Sheng‐Mei , Jia Guo‐Qing , Wang Qing‐Nan , Li Can 
Published: October 2021

AbstractLewis‐acid properties of the coordinatively unsaturated metal ions are highly relevant to the coordination environment; however, it remains a challenge to establish the coordination structure‐activity relationship, especially in heterogeneous catalysis. Here, a typical metal‐organic framework, ZIF‐8, is selected as the precursor to prepare Lewis‐acid based Zn−N/P−C mononuclear catalysts, with well‐designed external structures but difference in the local coordination. The obtained mononuclear Zn(II) catalysts can not only inherit the advantages of MOF in coordination, but also simulate the homogeneous environment during the catalysis owing to the monodispersed metal sites in ZIF‐8. Eventually, relation between coordination and Lewis‐acid property toward epoxide hydroxylation has been illustrated. Results show the substituted coordination atom of P and the decrease of coordination number strongly enhance the Lewis‐acidity of Zn2+, causing the TOF values changes from 8.7 to 80.1 h−1 based on Zn content. The work affords an understanding and inspiration of coordination environment matters toward Lewis‐acid catalysis in organic transformations.
Recent Progress in Advanced Organic Photovoltaics: Emerging Techniques and Materials
Authors: Sharma Tejasvini , Mahajan Prerna , Adil Afroz Mohammad , Singh Anupriya , Yukta  , Kumar Tailor Naveen , Purohit Smruti , Verma Sonali , Padha Bhavya , Gupta Vinay , Arya Sandeep , Satapathi Soumitra 
Published: October 2021

AbstractOrganic photovoltaics have received active research interest during the past 30 years due to their low cost, flexibility, easy scalability, and robustness. Recently, several efforts have been made to enhance their power conversion efficiency (PCE) and stability by considering advanced photon harvesting technology, utilization of novel donor–acceptor materials, and optimizing device design strategy. Specifically, the photon multiplication process like singlet fission (SF) and design of novel materials, including low‐bandgap conjugated polymers and non‐fullerene acceptors (NFA), have led to the development of advanced organic photovoltaics with PCE close to theoretical Shockley–Queisser (SQ) limit. Here, an up‐to‐date overview of the recent progress during the last five years in advanced organic photovoltaics with a special focus on emerging techniques and materials was reported. Further, various designing and deployment strategies for these processes and materials were explored along with their properties, challenges, and achievements. Finally, a strategy for the next‐stage research directions was analyzed and proposed that could drive this field even further beyond laboratory research to reach the final goal of commercialization.
Repetitive short‐pulsed illumination efficiently activates photoactivatable‐Cre as continuous illumination in embryonic stem cells and pre‐implantation embryos of transgenic mouse
Authors: Kishi Kanae , Koyama Hiroshi , Oka Sanae , Kato Azusa , Sato Moritoshi , Fujimori Toshihiko 
Published: October 2021

SummaryThe Cre‐loxP system has been widely used for specific DNA recombination which induces gene inactivation or expression. Recently, photoactivatable‐Cre (PA‐Cre) proteins have been developed as a tool for spatiotemporal control of the enzymatic activity of Cre recombinase. Here, we generated transgenic mice bearing a PA‐Cre gene and systematically investigated the conditions of photoactivation for the PA‐Cre in embryonic stem cells (ESCs) derived from the transgenic mice and in a simple mathematical model. Cre‐mediated DNA recombination was induced in 16% of the PA‐Cre ESCs by 6 hr continuous illumination. We show that repetitive pulsed illumination efficiently induced DNA recombination with low light energy as efficient as continuous illumination in the ESCs (96 ± 15% of continuous illumination when pulse cycle was 2 s), which was also supported by a minimal mathematical model. DNA recombination by the PA‐Cre was also successfully induced in the transgenic mouse pre‐implantation embryos under the developed conditions. These results suggest that strategies based on repetitive pulsed illumination are efficient for the activation of photoactivatable Cre and, possibly other photo‐switchable proteins.
Echocardiographic assessment of radial right ventricular function in heart transplant recipients
Authors: Atzenhoefer Marc , Jahangir Arshad , Payne Abby , Hendawi Mohamed , Dakwar Omar , Ali Mahmoud , Thohan Vinay , Muthukumar Lakshmi 
Published: October 2021

AbstractAimsRight ventricular (RV) allograft dysfunction is present in half of all heart transplant (HT) recipients. Non‐invasive assessment of RV function in the setting of rejection is not well described. We outline an echocardiographic technique, short‐axis fractional area change (SAXFAC), to evaluate RV function in the HT population and correlate this with the grade of pathologic rejection.Methods and resultsWe retrospectively reviewed the electronic medical records of 110 people who received a HT between 1 January 2015 and 29 February 2020 and had no evidence of rejection. One hundred eighty‐two transthoracic echocardiograms (TTEs) completed up to 1 year from the date of transplantation were analysed for the target acoustic window, the parasternal mid‐ventricular short‐axis view. Sixty‐one TTEs from 23 healthy transplants were deemed appropriate for SAXFAC determination. Thirty‐three organ recipients with at least grade 1R allograft rejection were also identified, and their TTEs screened for SAXFAC analysis. Two expert readers independently calculated SAXFAC as follows: RV end‐diastolic area minus end‐systolic area divided by end‐diastolic area. Using commercially available software (Epsilon, Ann Arbor, Michigan), we quantified RV radial strain, longitudinal strain, and apical fractional area change (FAC). Twenty‐eight transplant recipients with grade 0R or 1R rejection and nine patients with clinically significant rejection completed the study analysis. SAXFAC demonstrated significant variability in the entire population with an inverse relationship to severity of allograft rejection (P ≤ 0.01). Radial strain and FAC were also associated with clinically significant rejection (P ≤ 0.01).ConclusionsShort‐axis fractional area change is a simple two‐dimensional technique to assess RV function in HT recipients and showed no significant inter‐observer variability. In our small, single‐centre, retrospective case series, lower SAXFAC values were associated with clinically significant allograft rejection. The small sample size and infrequent occurrence of rejection make our observations hypothesis‐generating only. We advocate dedicated RV SAXFAC imaging planes be included when assessing allograft function.
A review of sustainable biodiesel production using biomass derived heterogeneous catalysts
Authors: Maroa Semakula , Inambao Freddie 
Published: October 2021

AbstractThe production of biodiesel through chemical production processes of transesterification reaction depends on suitable catalysts to hasten the chemical reactions. Therefore, the initial selection of catalysts is critical although it is also dependent on the quantity of free fatty acids in a given sample of oil. Earlier forms of biodiesel production processes relied on homogeneous catalysts, which have undesirable effects such as toxicity, high flammability, corrosion, by‐products such as soap and glycerol, and high wastewater. Heterogeneous catalysts overcome most of these problems. Recent developments involve novel approaches using biomass and bio‐waste resource derived heterogeneous catalysts. These catalysts are renewable, non‐toxic, reusable, offer high catalytic activity and stability in both acidic and base conditions, and show high tolerance properties to water. This review work critically reviews biomass‐based heterogeneous catalysts, especially those utilized in sustainable production of biofuel and biodiesel. This review examines the sustainability of these catalysts in literature in terms of small‐scale laboratory and industrial applications in large‐scale biodiesel and biofuel production. Furthermore, this work will critically review natural heterogeneous biomass waste and bio‐waste catalysts in relation to upcoming nanotechnologies. Finally, this work will review the gaps identified in the literature for heterogeneous catalysts derived from biomass and other biocatalysts with a view to identifying future prospects for heterogeneous catalysts.
A review of tin disulfide (SnS2) composite electrode materials for supercapacitors
Authors: Setayeshmehr Mahboobeh , Haghighi Maryam , Mirabbaszadeh Kavoos 
Published: October 2021

AbstractThe rapid growth of the global economy has substantially increased fossil fuel consumption, which brings about two challenges: the destruction of the existing fossil fuel reserves and the emergence of severe environmental problems, such as climate pollution. Therefore, developing clean energy resources and relevant technologies is an urgent priority. In this regard, the enhancement of energy storage technologies and devices gain paramount importance. Two types of energy storage devices are batteries and supercapacitors. Supercapacitors, especially, double layer supercapacitors and pseudo‐capacitors, have attracted more attention than batteries. They possess better characteristics, such as higher‐power density and longer cycle life‌. Various nanocomposite materials, such as carbon (graphene or carbon nanotubes), metal oxides (sulfide), and conductive polymers, are used in the construction of supercapacitor electrodes. Among these materials, tin (IV) sulfide is the most widely utilized material as its layered structure is capable of forming two‐dimensional morphologies. Owing to its abundance in nature, nontoxicity, and cheapness, tin (IV) sulfide is regarded as a promising material for constructing efficient electrodes. The faradic behavior of this material also makes it suitable for supercapacitor applications. The present review article aims to survey and summarize the findings of the studies on tin (IV) sulfide and its utility as an electrode material in supercapacitors. This article also gives an overview of the solutions proposed to improve the performance of this material in supercapacitors.
Optimization of biodegradable paper cup packaging coated with whey protein isolate and rice bran wax as potential popcorn package
Authors: Ganjizadeh Zavareh Sedigheh , Javanmard Dakheli Majid , Tajeddin Behjat 
Published: October 2021

AbstractBiodegradable paper cups coated with rice bran wax and whey protein isolate were designed to package popcorn. Coatings with different concentrations of whey protein isolate (5.5, 7.75, and 10% w/v) and rice bran wax (0.2, 0.4, and 0.6% w/v) were applied on the outer surface of the paper cups. Thickness, color changes, Young's modulus and tensile strength, water vapor transmission rate (WVTR) of the coated and uncoated cups, and also popcorns properties (pH, texture, and sensory properties) were evaluated. Water vapor transmission rate, Young's modulus, thickness, total color change index, and tensile strength of coated cups with the optimal coating formulation was 19.785 (g/m2 day), 11.810 (MPa), 276.583 (µm), 1.839, and 11.222 (MPa), respectively. The results showed that paper cup coating increased thickness and yellowness and reduced the brightness, Young's modulus, and WVTR. Coating had a positive effect on the pH and texture of popcorns packaged in coated cups than samples packed in uncoated cups (p < .05). With increasing storage time due to moisture absorption, popcorn changes from crisp to viscoelastic and increases tissue firmness (p < .05). Popcorns’ taste in uncoated cups had gained significantly lower scores by panelists compared with the samples packed in coated cups. There was a significant decrease in the general acceptance of popcorn during storage and also the type of coating used in the packaging cup (p < .05). Storage time and type of coating showed no significant effect on the moisture content, odor, and appearance of popcorn. In sensory evaluation, the coated packaging increased the taste, no difference in odor and appearance, and increased the overall acceptance of popcorn compared to the sample in uncoated cups. In general, the results showed that paper cup coating could be a new approach for barrier property improvement in paper‐based food packaging and extending the shelf life of the products.
Clinicopathological features and resistance mechanisms in HIP1‐ALK‐rearranged lung cancer: A multicenter study
Authors: Kang Jin , Deng Qiu‐Mei , Peng Kai‐Cheng , Li Peng , Zhu Bao‐Ting , Wang Pan , Chu Xiang‐Peng , Zhong Wen‐Zhao , Chen Hua‐Jun , Wang Wen‐Xian , Chen Hua‐Fei , Rao Chuang‐Zhou , Xu Chun‐Wei , Yang Jin‐Ji 
Published: October 2021

AbstractAnaplastic lymphoma kinase (ALK)‐rearranged non‐small cell lung cancer (NSCLC) respond well to ALK tyrosine kinase inhibitors (TKIs), and echinoderm microtubule‐associated protein‐like 4 (EML4)‐ALK‐rearranged NSCLC accounts for the majority of those patients. However, few studies have evaluated ALK‐TKIs treatment for patients with huntingtin‐interacting protein 1 (HIP1)‐ALK fusions. This retrospective study evaluated the clinicopathological characteristics, genomic features, response to ALK‐TKIs, and resistance mechanisms in 11 cases with HIP1‐ALK fusions from five Chinese centers. Patients who received crizotinib at the Chinese centers had an objective response rate of 90% [9/10 cases, 95% confident index (CI): 54.1%–99.5%], median progression‐free survival of 17.9 months (95% CI: 5.8–NA months), and median overall survival of 58.8 months (95% CI: 24.7–NA months). One patient who received first‐line lorlatinib treatment achieved partial response for > 26.5 months. Despite the small sample size, HIP1‐ALK (H21:A20) variant was the most common variant (four of 11 cases, 36.4%) and associated with better outcomes. Among the 11 cases, there were eight patients having available specimens for genetic testing before ALK‐TKIs treatment and four patients undergoing biopsy after ALK‐TKIs failure. The most common coexisting gene was TP53 among 11 patients and two of four patients after crizotinib failure harbored acquired ALK mutations (e.g., L1152V/Q1146K and L1196M). Brigatinib treatment appeared to be effective for a patient who failed crizotinib treatment because of the L1152V/Q1146K mutations, which might be related to increased binding affinity to these mutants. Although HIP1‐ALK‐rearranged NSCLC appears to initially respond well to ALK‐TKIs, crizotinib resistance may be correlated with the AKAP9‐BRAF fusion, ALK compound mutations (L1152V/Q1146K), and the ALK L1196M mutation. Larger studies are needed to evaluate the significance of HIP1‐ALK‐rearranged NSCLC.
Construction of 5H‐Dibenzo[c,e]azepine Framework from Dibenzothiophene Dioxides andN‐Benzylimines through SNAr Reactions
Authors: Furukawa Tomoki , Yanagi Tomoyuki , Kaga Atsushi , Saito Hayate , Yorimitsu Hideki 
Published: October 2021

AbstractTreatment of a mixture of dibenzothiophene dioxides and benzaldehydeN‐benzylimines with potassium hexamethyldisilazide induces sequential intermolecular and intramolecular SNAr reactions to eventually form the corresponding 5H‐dibenzo[c,e]azepines without any formation of the conceivable five‐membered fluorene derivatives.
Melatonin and melatonin‐agonists for metabolic syndrome components in patients treated with antipsychotics: A systematic review and meta‐analysis
Authors: Miola Alessandro , Fornaro Michele , Sambataro Fabio , Solmi Marco 
Published: October 2021

AbstractObjectiveMetabolic side effects are a limiting factor in the use of antipsychotics, which remain the cornerstone of long‐term management of patients with severe mental illness. There is contrasting evidence on a possible role of melatonin and melatonin‐agonists in attenuating antipsychotic‐induced metabolic abnormalities.DesignWe conducted a systematic review (PubMed, PsycInfo, Cochrane databases, up to August 2020) and a random‐effect meta‐analysis of double‐blind, randomized placebo‐controlled trials (RCTs) involving melatonin and melatonin‐agonists in the treatment of antipsychotic‐induced metabolic changes. The primary outcome was the standardized mean difference (SMD) of composite metabolic outcomes built with metabolic syndrome components. Secondary outcomes were individual metabolic syndrome components, and other anthropometric, glucose metabolism, lipid profile, and psychopathology measures.ResultsOut of the initial 41 studies, six documented five separate RCTs randomizing 248 patients (126 to melatonin/ramelteon, 122 to placebo) affected by schizophrenia‐spectrum disorders and bipolar disorder. Melatonin/ramelteon outperformed placebo on the primary outcome (SMD −0.28, 95% CI = −0.39 ÷ −0.168), as well as on all individual components of metabolic syndrome (systolic blood pressure MD −3.266, 95% CI = −6.020 ÷ −0.511; fasting glucose MD −3.766, 95% CI = −5.938 ÷ −1.593; triglycerides MD −9.800, 95% CI = −19.431 ÷ −0.169; HDL MD 2.995, 95% CI = 0.567 ÷ 5.423), except waist circumference.ConclusionsMelatonin/ramelteon augmentation may be beneficial for non‐anthropometric metabolic syndrome components in patients treated with antipsychotics.