bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between famine exposure during early life and ascending aorta dilatation in adults
Authors: Huang Yu-Qing , Liu Lin , Lo Kenneth Ka Ho , Yu Yu-Ling , Chen Chao-Lei , Huang Jia-Yi , Zhang Bin , Feng Ying-qing 
Published: April 2021

AbstractThe relationship between exposure to famine in early life and the risk of ascending aorta dilatation (AAD) in adulthood is still unclear; therefore, we aimed to examine the association in the Chinese population. We investigated the data of 2598 adults who were born between 1952 and 1964 in Guangdong, China. All enrolled subjects were categorised into five groups: not exposed to famine, exposed during fetal period, and exposed during early, mid or late childhood. AAD was assessed by cardiac ultrasound. Multivariate logistic regression and interaction tests were performed to estimate the OR and CI on the association between famine exposure and AAD. There were 2598 (943 male, mean age 58·3 ± 3·68 years) participants were enrolled, and 270 (10·4 %) subjects with AAD. We found that famine exposure (OR = 2·266, 95 % CI 1·477, 3·477, P = 0·013) was associated with elevated AAD after adjusting for multiple confounders. In addition, compared with the non-exposed group, the adjusted OR for famine exposure during fetal period, early, mid or late childhood were 1·374 (95 % CI 0·794, 2·364, P = 0·251), 1·976 (95 % CI 1·243, 3·181, P = 0·004), 1·929 (95 % CI 1·237, 3·058, P = 0·004) and 2·227 (95 % CI 1·433, 3·524, P < 0·001), respectively. Subgroup analysis showed that the effect of famine exposure on the association with AAD was more pronounced in female, current smokers, people with BMI ≥ 24 kg/m2 and hypertensive patients. We observed that exposure to famine during early life was linked to AAD in adulthood.
Exogenous salicylic acid improves resistance of aphid-susceptible wheat to the grain aphid, Sitobion avenae (F.) (Hemiptera: Aphididae)
Authors: Feng Jian-Lu , Zhang Jie , Yang Jun , Zou Ling-Ping , Fang Ting-Ting , Xu Huan-Li , Cai Qing-Nian 
Published: April 2021

AbstractSalicylic acid (SA), a phytohormone, has been considered to be a key regulator mediating plant defence against pathogens. It is still vague how SA activates plant defence against herbivores such as chewing and sucking pests. Here, we used an aphid-susceptible wheat variety to investigate Sitobion avenae response to SA-induced wheat plants, and the effects of exogenous SA on some defence enzymes and phenolics in the plant immune system. In SA-treated wheat seedlings, intrinsic rate of natural increase (rm), fecundity and apterous rate of S. avenae were 0.25, 31.4 nymphs/female and 64.4%, respectively, and significantly lower than that in the controls (P < 0.05). Moreover, the increased activities of phenylalanine-ammonia-lyase, polyphenol oxidase (PPO) and peroxidase in the SA-induced seedlings obviously depended on the sampling time, whereas activities of catalase and 4-coumarate:CoA ligase were suppressed significantly at 24, 48 and 72 h in comparison with the control. Dynamic levels of p-coumaric acid at 96 h, caffeic acid at 24 and 72 h and chlorogenic acid at 24, 48 and 96 h in wheat plants were significantly upregulated by exogenous SA application. Nevertheless, only caffeic acid content was positively correlated with PPO activity in SA-treated wheat seedlings (P = 0.031). These findings indicate that exogenous SA significantly enhanced the defence of aphid-susceptible wheat variety against aphids by regulating the plant immune system, and may prove a potential application of SA in aphid control.
Tourmaline growth and evolution in S-type granites and pegmatites: constraints from textural, chemical and B-isotopic study from the Gangpur Schist Belt granitoids, eastern India
Authors: Chakraborty Tuhin 
Published: April 2021

AbstractAn extensive dataset of major- and trace-element and B-isotope composition related to the compositional variation of the tourmalines from the S-type granite and pegmatite from the Upper Bonai and Gangpur Group granitoids, eastern India, is provided. The Gangpur Schist Belt, consisting of the Upper Bonai and Gangpur Group, lies at the eastern end of the Proterozoic Central Indian Tectonic Zone. An attempt to constrain the source of the boron isotope and describe the magmatic–hydrothermal evolution of the granite–pegmatite system is made. The tourmalines record generally low trace-element concentrations, with the exception of some elements such as Zn, Li, Ga, Mn and Ti. The Zn and Li concentration increases from the tourmalines in the granites to the tourmalines in the pegmatite. Trace-element compositions also vary slightly from the core tourmaline to the rim tourmaline. Tourmalines in granites/pegmatites are mostly Fe-rich schorl, and have S-type B-isotopic signature (δ11B = −10‰ to −12‰). Their chemistries reflect changing salinities of the granitic melts as well as vapour exsolution during progressive crystallization. This study indicates that the tourmalines in the pegmatites crystallized from evolved flux-element-rich (F, B, Li) melt, probably after the crystallization of granite-forming melt.
Threats at Home and Abroad: Interstate War, Civil War, and Alliance Formation
Authors: Edry Jessica , Johnson Jesse C. , Leeds Brett Ashley 
Published: April 2021

AbstractIn the current era, many of the military threats that state leaders face come from domestic and transnational nonstate actors. Military alliances are recognized as an important policy strategy to counter military threats, but existing research has primarily been focused on threats from other states and has difficulty uncovering a consistent relationship between external threat and alliance formation. We argue that this discrepancy arises from the failure to recognize that many threats are not external to the state. We contend that alliance formation is motivated both by external threats from other states and by internal threats that make civil conflict more likely. Moreover, we argue that leaders design alliance obligations differently when faced with internal threats. An empirical analysis of alliance formation from 1946 to 2009 shows that while external threats motivate the formation of defense pacts, internal threats encourage the formation of consultation pacts. Internal threats with the greatest potential for internationalization also encourage the formation of neutrality/nonaggression pacts. This research deepens our understanding of how states design security policies to deal with the threats posed by nonstate actors, a salient concern of leaders in the twenty-first century, and helps us to understand the variety of alliance obligations that we observe.
First record of clasper malformation of Pseudobatos buthi (Chondrichthyes: Rhinobatidae) in the Gulf of California
Authors: Soto-López Katherin , García-Vázquez Gabriela , Martínez-Ayala Julio C. , Galván-Magaña Felipe , Ochoa-Báez Rosa I. 
Published: April 2021

AbstractElasmobranchs in the Gulf of California have been found with malformations, probably originated during embryonic development or caused by environmental anomalies and pollution associated with intense mining activity in the region. Clasper malformations are reported for the first time in two specimens of Pseudobatos buthi, a species recently described from the Gulf of California. The function of the claspers was not affected by the size difference, because specimens presented the distinctive characteristics of an adult individual. The reproductive system did not show any malformation, with symmetrical testes. Histological analysis of the testes revealed a normal spermatogenic development. To elucidate the causes and to detect a possible effect of the morphological malformations due to high levels of heavy metals, trace concentration values (cadmium, copper, iron, manganese, silver, lead and zinc) were determined in muscle and liver. Cadmium and lead concentrations in the muscle of the two specimens were below the permissible limit for human consumption (<0.05 mg kg−1); however, iron and zinc presented high values (0.455, 4.024 mg kg−1 in muscle and 21.931, 3.694 mg kg−1 in liver respectively). Mining activity and heavy metal pollution in the sampling area may have caused the malformations, which might be attributed to the high values of iron and zinc discovered in the muscle and liver.
The Battle for Post-Habsburg Trieste/Trst: State Transition, Social Unrest, and Political Radicalism (1918–23)
Authors: Bresciani Marco 
Published: April 2021

AbstractIn spite of the recent transnational turn, there continues to be a considerable gap between Fascist studies and the new approaches to the transitions, imperial collapses, and legacies of post–World War I Europe. This article posits itself at the crossroads between fascist studies, Habsburg studies, and scholarship on post-1918 violence. In this regard, the difficulties of the state transition, the subsequent social unrest, and the ascent of new forms of political radicalism in post-Habsburg Trieste are a case in point. Rather than focusing on the “national strife” between “Italians” and “Slavs,” this article will concentrate on the unstable local relations between state and civil society, which led to multiple cycles of conflict and crisis. One of the arguments it makes is that in post-1918 Trieste, where the different nationalist groups contended for a space characterized by multiple loyalties and allegiances, Fascists claimed to be the movement of the “true Italians,” identified with the Fascists and their sympathizers. Accordingly, while targeting the alleged enemies of the “Italian nation” (defined as “Bolsheviks,” “Austrophiles,” and “Slavs”), they aimed to polarize the Italian-speaking community along different political fault lines to reconfigure relations between the state and civil society.
Spatial conservation prioritization considering socioeconomic costs and degradation conditions in the Southwest China Biodiversity Hotspot
Authors: Fu Wei , Ding Qi , Sun Zhe , Xu Tao 
Published: April 2021

SummaryThere have been calls for the expansion of protected areas (PAs) to tackle the ongoing biodiversity loss, yet it is unclear where future PAs might help to protect biodiversity in degraded landscapes under the conservation planning principles of complementarity, connectivity and cost-effectiveness. Our conservation goal is to increase the PA network coverage to up to 30% of the landscape of the Zhangjiang River Basin for target species in the karst area of southwest China, a global biodiversity hotspot.Zonation 4GUIwas used to evaluate the adequacy of current PAs and to strategically expand PAs while maximizing the coverage of target species and considering ecological integrity and socioeconomic activities. The results show that significant habitat degradation has occurred across 77.9% of the basin. The current PAs cover 6.3% of the site and represent 8.7% of the total distribution of key species. With regards to the threshold of protection of 30% of the area, protecting an additional 27.2% of the site under an ecological integrity prioritization scenario and a scenario of the socioeconomic costs involved in iteration would cover 93.5% and 80.4% of the ranges of the key species, respectively. Our results can be used to inform the upcoming actions associated with karst area conservation-related policies.
Estimating the effects of reopening of schools on the course of the epidemic of COVID-19
Authors: Massad Eduardo , Amaku Marcos , Tadeu Covas Dimas , Fernandes Lopez Luis , Coutinho Francisco Antonio Bezerra 
Published: April 2021

AbstractIn this paper, we present a method to estimate the risk of reopening of schools illustrated with the case of the State of São Paulo, Brazil. The model showed that, although no death of children would result from the reopening of the schools in the three cities analysed, the risk of asymptomatic and symptomatic cases and secondary cases among teachers, school staff and relatives of the children is not negligible. Although the epidemic hit different regions with different intensities, our model shows that, for regions where the incidence profile is similar to the cities analysed, the risk of reopening of schools is still too high. This in spite of the fact that incidences in these cities were declining in the period of the time considered. Therefore, although we cannot extend the result to the entire country, the overall conclusion is valid for regions with a declining incidence and it is even more valid for regions where incidence is increasing. We assumed a very conservative level of infection transmissibility of children of just 10% as that of adults. In spite of the very low level of transmissibility is assumed, the number of secondary cases caused by infected children among teachers, school staff and relatives varied from 2 to 85. It is, therefore, too soon to have any degree of confidence that reopening of schools before the advent of a vaccine is the right decision to take. The purpose of our model and simulations is to provide a method to estimate the risk of school reopening, although we are sure it could be applied as a guide to public health strategies.
Immunogenicity and safety of a quadrivalent meningococcal tetanus toxoid-conjugate vaccine administered concomitantly with other paediatric vaccines in toddlers: a phase III randomised study
Authors: Dhingra M. S. , Namazova-Baranova L. , Arredondo-Garcia J. L. , Kim K.-H. , Limkittikul K. , Jantarabenjakul W. , Perminova O. , Kobashi I. A. R. , Bae C.-W. , Ojeda J. , Park J. , Chansinghakul D. , B'Chir S. , Neveu D. , Bonaparte M. , Jordanov E. 
Published: April 2021

Abstract
Invasive meningococcal disease has high morbidity and mortality, with infants and young children among those at greatest risk. This phase III, open-label, randomised study in toddlers aged 12–23 months evaluated the immunogenicity and safety of meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT), a tetanus toxoid conjugated vaccine against meningococcal serogroups A, C, W and Y, when coadministered with paediatric vaccines (measles, mumps and rubella [MMR]; varicella [V]; 6-in-1 combination vaccine against diphtheria, tetanus, pertussis, polio, hepatitis B and Haemophilus influenzae type b [DTaP-IPV-HepB-Hib] and pneumococcal conjugate vaccine [PCV13])(NCT03205371). Immunogenicity to each meningococcal serogroup was assessed by serum bactericidal antibody assay using human complement (hSBA). Vaccine safety profiles were described up to 30 days post-vaccination. A total of 1183 participants were enrolled. The proportion with seroprotection (hSBA ≥1:8) to each meningococcal serogroup at Day 30 was comparable between the MenACYW-TT and MenACYW-TT + MMR + V groups (≥92 and ≥96%, respectively), between the MenACYW-TT and MenACYW-TT + DTaP-IPV-HepB-Hib groups (≥90% for both) and between the MenACYW-TT and MenACYW-TT + PCV13 groups (≥91 and ≥84%, respectively). The safety profiles of MenACYW-TT, and MMR + V, DTaP-IPV-HepB-Hib, and PCV13, with or without MenACYW-TT, were generally comparable. Coadministration of MenACYW-TT with paediatric vaccines in toddlers had no clinically relevant effect on the immunogenicity and safety of any of the vaccines.
Cartographies of catastrophe: mapping World War II destruction in Germany and Poland
Authors: Elżanowski Jerzy , Enss Carmen M. 
Published: April 2021

AbstractPost-catastrophic damage cartography constitutes a serious research gap in the field of urban history. While fire and war damage maps have been made for centuries, qualitative analyses of these documents, especially from a comparative and transnational perspective, have appeared only recently. In response, this article tracks the coeval emergence of urban archaeology, heritage zoning and war damage mapping across Europe. Based on detailed studies of early post-war Munich and Warsaw, it demonstrates that damage mapping was as much about recording loss as it was about reshaping and reimagining Europe's historic city centres.
Relative abundance of pluripotency-associated candidate genes in immature oocytes andin vitro-produced buffalo embryos (Bubalus bubalis)
Authors: Kumar Satish , Chauhan Manmohan Singh 
Published: April 2021

SummaryThe present study was undertaken to analyze the relative abundance (RA) of pluripotency-associated genes (NANOG,OCT4,SOX2, c-MYC, andFOXD3) in different grades of immature oocytes and various stages ofin vitro-produced buffalo embryos using RT-qPCR. Results showed that the RA ofNANOG,OCT4, andFOXD3transcripts was significantly higher (P< 0.05) in A grade oocytes compared with the other grades of oocytes. The RA of the c-MYCtranscript was significantly higher (P< 0.05) in A grade compared with the C and D grades of oocytes, but the values did not differ significantly from the B grade of oocytes. The RA of theSOX2transcript was almost similar in all grades of the oocytes. The expression levels ofNANOG(P> 0.05),OCT4(P> 0.05), c-MYC(P> 0.05) andSOX2(P< 0.05) were higher in the blastocysts compared with the other stages of the embryos. Markedly,FOXD3expression was significantly higher (P< 0.05) in 8–16-cell embryos compared with the 2-cell and 4-cell embryos and blastocyst, but did not differ significantly from the morula stage of the embryos. In the study, the majority of pluripotency-associated genes showed higher expression in A grade immature oocytes. Therefore, it is concluded that the A grade oocytes appeared to be more developmental competent and are suitable candidates for nuclear cloning research in buffalo. In buffalo,NANOG,OCT4,SOX2, and c-MYCare highly expressed in blastocysts compared with the other stages of embryos.
Writing instruments for managing provincial resources during the Roman occupation of northeast Hispania (2nd and 1st c. BCE)
Authors: Vila Oriol Olesti 
Published: April 2021

AbstractThis article analyzes the presence of writing instruments dating to the 2nd–1st c. BCE at several archaeological sites of the northeastern Iberian peninsula (current Catalonia), attempting to assess their historical, social, and economic interest. The evidence of the ancient literary sources, as well as the archaeological contexts in which these objects appeared, allow us to interpret these writing instruments as part of the mechanisms of control and recordkeeping deployed by Rome in this territory during the long and complex process of conquest.
Optimisation of Varian TrueBeam head, thorax and pelvis CBCT based on patient size
Authors: Agnew Christina E. , McCallum Candice , Johnston Gail , Workman Adam , Irvine Denise M. 
Published: April 2021

AbstractPurpose:The aim of this study was to optimise patient dose and image quality of Varian TrueBeam cone beam computed tomography (CBCT) pelvis, thorax and head and neck (H&N) images based on patient size.Methods:An elliptical phantom of small, medium and large size was designed representative of a local population of pelvis, thorax and H&N patients. The phantom was used to establish the relationship between image noise, CT and CBCT exposure settings. Using this insight, clinical images were optimised in phases and the image quality graded qualitatively by radiographers. At each phase, the time required to match the images was recorded from the record and verify system.Results:Average patient diameter was a suitable metric to categorise patient size. Phantom measurements showed the power relationship between noise and CBCT exposure settings of value −0·15, −0·35 and −0·43 for thorax, pelvis and H&N, respectively. These quantitative phantom measurements provided confidence that phased variation of ~±20% in mAs should result in clinically usable images. Qualitative assessment of almost 2000 images reduced the exposure settings in H&N images by −50%, thorax images by up to −66% and pelvis images by up to −80%. These optimised CBCT settings did not affect the time required to match images.Findings:Varian TrueBeam CBCT mAs settings have been optimised for dose and image quality based on patient size for three treatment sites: pelvis, thorax and H&N. Quantitative phantom measurements provided insight into the magnitude of change to implement clinically. The final optimised exposure settings were determined from radiographer qualitative image assessment.
Visualising the proximal urethra by MRI voiding scan: results of a prospective clinical trial evaluating a novel approach to radiotherapy simulation for prostate cancer
Authors: Blitzer Grace C. , Yadav Poonam , Ko Huaising C. , Kuczmarska-Haas Aleksandra , Burr Adam M. , Bassetti Michael F. , Steinhoff Daniel J. , Borchert Kailee N. , Meudt Jason J. , Hebel Dustin J. , Bailey Stephanie K. , Morris Zachary S. 
Published: April 2021

AbstractBackground:Delineating the proximal urethra can be critical for radiotherapy planning but is challenging on computerised tomography (CT) imaging.Materials and methods:We trialed a novel non-invasive technique to allow visualisation of the proximal urethra using a rapid sequence magnetic resonance imaging (MRI) protocol to visualise the urinary flow in patients voiding during the simulation scan.Results:Of the seven patients enrolled, four were able to void during the MRI scan. For these four patients, direct visualisation of urinary flow through the proximal urethra was achieved. The average volume of the proximal urethra contoured on voiding MRI was significantly higher than the proximal urethra contoured on CT, 4·07 and 1·60 cc, respectively (p = 0·02). The proximal urethra location also differed; the Dice coefficient average was 0·28 (range 0–0·62).Findings:In this small, proof-of-concept prospective clinical trial, the volume and location of the proximal urethra differed significantly when contoured on a voiding MRI scan compared to that determined by a conventional CT simulation. The shape of the proximal urethra on voiding MRI may be more anatomically correct compared to the proximal urethra shape determined with a semi-rigid catheter in place.
Native and foreign healthcare workers’ knowledge of appropriate use of antibiotics: a prospective pre-post study in Danish nursing homes
Authors: Rasmussen Ida Scheel , Hansen Matilde Bøgelund , Marloth Tina , Arpi Magnus , Jarløv Jens Otto , Arnold Sif Helene , Mogensen Dorthe , Jensen Jette Nygaard 
Published: April 2021

Abstract

Aim:
The aim was to determine the association between healthcare workers’ (HCWs) country of birth and their knowledge of appropriate use of antibiotics, and whether the association changed after an educational intervention.

Background:
Older residents in nursing homes have been recognized to receive excessively antibiotic treatments. HCWs often represent an important link between the older resident and the general practitioner prescribing the antibiotics, thus their knowledge of appropriate use of antibiotics is important.

Methods:
This study was conducted as a prospective pre-post study. Totally, 312 HCWs from 7 nursing homes in Denmark were included. For statistical analyses, χ2 test and a linear mixed regression model were applied.

Findings:
Native HCWs were more likely to have a higher percentage of correct responses to single statements related to knowledge of appropriate use of antibiotics. Native HCWs had a significantly higher knowledge-of-antibiotic score compared to foreign HCWs (−7.53, P < 0.01). This association remained significant after adjusting for relevant covariates (−5.64, P < 0.01). Native HCWs’ mean change in knowledge-of-antibiotic score after the intervention did not differ from the foreign HCWs’ mean change in knowledge-of-antibiotic score.

Conclusion:
Our findings indicate that HCWs born outside Denmark reveal a lower knowledge-of-antibiotic score than HCWs born in Denmark despite comparable educational backgrounds. All participants increased their knowledge from baseline to follow-up. Our findings also indicate that an educational seminar cannot equalize the difference in knowledge between native and foreign HCWs. Studies with larger sample size and a more detailed measurement of cultural identity should investigate this association further.