bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID-19 on perceived wellbeing, self-management and views of novel modalities of care among medically vulnerable patients in Singapore
Authors: Yoon Sungwon , Hoe Pei Shan , Chan Angelique , Malhotra Rahul , Visaria Abhijit , Matchar David , Goh Hendra , Seng Bridget , Ramakrishnan Chandrika , Koh Mariko S , Yee Tiew Pei , Nadarajan Gayathri Devi , Bee Yong Mong , Graves Nicholas , Jafar Tazeen H. , Ong Marcus EH 
Published: December 2021

Objectives This study aims to examine the impact of COVID-19 measures on wellbeing and self-management in medically vulnerable non-COVID patients and their views of novel modalities of care in Singapore. Methods Patients with cardiovascular disease (CVD), respiratory disease, chronic kidney disease, diabetes and cancer were recruited from the SingHealth cluster and national cohort of older adults. Data on demographics, chronic conditions and perceived wellbeing were collected using questionnaire. We performed multivariable regression to examine factors associated with perceived wellbeing. Qualitative interviews were conducted to elicit patient's experience and thematically analyzed. Results A total of 91 patients participated. Male patients compared with female patients perceived a lower impact of the pandemic on subjective wellbeing. Patients with CVD compared to those having conditions other than CVD perceived a lower impact. Impacts of the pandemic were primarily described in relation to emotional distress and interference in maintaining self-care. Hampering of physical activity featured prominently, but most did not seek alternative ways to maintain activity. Despite general willingness to try novel care modalities, lack of physical interaction and communication difficulties were perceived as main barriers. Discussion Findings underline the need to alleviate emotional distress and develop adaptive strategies to empower patients to maintain wellbeing and self-care.
Factors influencing postoperative pain management among nurses in selected district hospitals in Ghana
Authors: Menlah Awube , OseiAppiah Evans , Garti Isabella , Frempomaa Agyare Dorcas 
Published: December 2021

Background: Poorly managed postoperative pain is linked to numerous postoperative complications worldwide and in Ghana. This is due to the myriad of physical and psychological problems, such as lifelong chronic pain syndromes, impaired functionality and death. Purpose: The aim of this study was to assess the barriers and factors influencing postoperative pain management by Ghanaian nurses working in four hospitals. Methods: A quantitative descriptive cross-sectional design was employed for this study. Participants were recruited using a multistage sampling technique by which 146 returned their questionnaires out of 194 participants. The statistical analysis of data was done with the Statistical Package of Social Sciences (SPSS) 20.0 version. Results: Findings revealed that some verbal and non-verbal cues from patients such as facial grimacing, restlessness, irritability and distress, lack of concentration and moaning or crying (verbalisation) influenced how nurses controlled postoperative pain with analgesia. The participants also identified several barriers to influence postoperative pain management by nurses. Conclusion: In conclusion, postoperative pain control by nurses is influenced by several factors, and hence, nurses need to manage patients’ pain effectively in Ghana and abroad using multiple approaches.
Dynamic bearing capacity of point fixed corrugated metal profile sheets subjected to blast loading
Authors: Fischer Kai , van der Woerd Jan Dirk , Harwick Wilfried , Stolz Alexander 
Published: December 2021

Blast loading scenarios and the corresponding hazards have to be evaluated for infrastructure elements and buildings especially at industrial sites for safety and security issues. Point fixed corrugated metal sheets are often applied as façade elements and can become a hazard for humans if they are pulled off. This paper investigates the dynamic bearing capacity of such structural members in terms of their general bending behavior in the middle of the span and pull-out behaviors at the fixing points. The elements are fixed at two sides and the load transfer is uniaxial. An experimental series with static and dynamic tests forms the basis to identify the predominant failure modes and to quantify the maximum stress values that can be absorbed until the investigated structural members fail. The experimental findings are applied to create and to optimize an engineering model for the fast and effective assessment of the structural response. The aim is the derivation of a validated model which is capable to predict the blast loading behavior of metal sheets including arbitrary dimensions, material properties, and screw connections. Results of this study can be integrated into a systematic risk and resilience management process to assess expected damage effects and the evaluation of robustness.
Menopause as a well-being strategy: Organizational effectiveness, gendered ageism and racism
Authors: Targett Rosa , Beck Vanessa 
Published: December 2021

Objective This study considers the example of one council who deliberately implemented menopause considerations into their well-being strategy instead of instituting a menopause policy. This example is used to explore whether such a strategy is a more viable and effective alternative. Study Design An online survey was distributed amongst council workers and completed by 189 individuals. The questions covered respondents’ own experiences of menopause transition at work (where applicable) and the availability of information and support for menopause at work, as well as a range of contextual factors. Main outcome measures Experiences of workplace environments and relationships by those experiencing menopause. Results Results on menopause experiences in this council are comparable to those in organizations who have implemented menopause policies or guidelines. Contextual factors, including gendered vertical segregation and racism, are highlighted as important factors influencing the experience of menopause transition in the workplace. Conclusions Early indications suggest that integrating menopause support into a health and well-being strategy helps mainstream menopause issues amongst staff. Long-term assessment is required to consider whether it is more effective than introducing a menopause policy or guidelines.
A scoping review to inform care coordination strategies for youth with traumatic brain injuries: Care coordination tools
Authors: Shook Brandy , Palusak Cara , Davies Susan C , Lundine Jennifer P 
Published: December 2021

Introduction & importance Children with traumatic brain injury (TBI) report unmet needs several years after their injury and may require long-term care. However, this chronic health condition is often only treated and monitored in the short-term. Care for young persons with TBI often relies on parents to manage their child's complex care network. Effective care coordination can close these gaps and facilitate continuity of care for children with TBI. The purpose of this scoping review was to develop a better understanding of tools that improve care coordination for Children with Special Health Care Needs (CSHCN). This, in turn, can inform care for children with TBI. Methods A scoping review was conducted following the PRISMA framework and methodology. OVID/Medline, CINAHL, PsycINFO, EMBASE, and ERIC databases were searched for articles relevant to care coordination tools used with CSHCN. Results 21 articles met the criteria for inclusion in the review, and 6 major categories of care coordination tools were identified: telehealth, online health records and tools, care plans, inpatient discharge protocols, family training, and reminders. Discussion Studies examining telehealth, online tools, care plans, and family training care coordination interventions for CSHCN have shown positive outcomes and would be relevant strategies to improve the care of children with TBI. Future prospective research should investigate these tools to explore whether they might improve communication, reduce unmet needs, increase service access, and improve long-term outcomes for children with TBI.
The effect of moisture on the properties of cement-bonded particleboards made with non-traditional raw materials
Authors: Melichar Tomas , Meszarosova Lenka , Bydzovsky Jiri , Ledl Matej , Vasas Silvestr 
Published: December 2021

AbstractThe paper presents research into the changes of properties in cement-bonded particleboards caused by moisture saturation over the course of 504 h. Three particleboard variants were tested, all at the age of 18 months. The first is a standard production-line board manufactured by CIDEM Hranice, a.s. (identified as CP-R). The other two variants were modified by by-products of the particleboard manufacturing process—dust (CP-D) and a particulate mixture (CP-P). The experiment observed changes in the boards’ dimensions, volume, and mass. The effect of moisture on their basic material properties was also investigated. While the boards were being saturated by water, changes in their structure were examined using an optical microscope. It was found that the boards behave differently depending on their composition. Also there were differences in the dynamics of the property changes. The modified particleboards are more susceptible to dimensional and volume changes. Both, volume and mass undergo the most significant changes during the first 24 h. Cracks and air voids inside the wood chips begin to close upon contact with water as a result of swelling. It was observed by optical microscopy that this process occurs within 3 to 5 min since immersion in the water bath. Between 24 and 96 h the rate at which the air voids and pores are closing begins to decrease and there is a difference in the dynamics of mass and volume changes as well. Wet–dry cycling of the boards was analysed as well. Temperature and moisture fluctuations negatively affected particleboard behaviour and properties. Strength dropped up to 50%. Wider cracks in structure of the particleboards were detected by optical microscopy, namely in ITZ (internal transition zone) of cement matrix and spruce chips.
Integration of transcriptome and proteome profiles in placenta accreta reveals trophoblast over-migration as the underlying pathogenesis
Authors: Li Na , Hou Rui , Liu Caixia , Yang Tian , Qiao Chong , Wei Jun 
Published: December 2021

Abstract
Background
Placenta accreta (PA) is a major cause of maternal morbidity and mortality in modern obstetrics, few studies have explored the underlying molecular mechanisms.

Methods
In our study, transcriptome and proteome profiling were performed in placental tissues from ten participants including five cases each in the PA and control groups to clarify the pathogenesis of PA.

Results
We identified differential expression of 37,743 transcripts and 160 proteins between the PA and control groups with an overlap rate of 0.09%. The 33 most-significant transcripts and proteins were found and further screened and analyzed. Adhesion-related signature, chemotaxis related signatures and immune related signature were found in the PA group and played a certain role. Sum up two points, three significant indicators, methyl-CpG-binding domain protein 2 (MeCP2), podocin (PODN), and apolipoprotein D (ApoD), which participate in “negative regulation of cell migration”, were downregulated at the mRNA and protein levels in PA group. Furthermore, transwell migration and invasion assay of HTR-8/SVneo cell indicated the all of them impaired the migration and invasion of trophoblast.

Conclusion
A poor correlation was observed between the transcriptome and proteome data and MeCP2, PODN, and ApoD decreased in transcriptome and proteome profiling, resulting in increased migration of trophoblasts in the PA group, which clarify the mechanism of PA and might be the biomarkers or therapy targets in the future.
Epigenetic features improve TALE target prediction
Authors: Erkes Annett , Mücke Stefanie , Reschke Maik , Boch Jens , Grau Jan 
Published: December 2021

Abstract
Background
The yield of many crop plants can be substantially reduced by plant-pathogenic Xanthomonas bacteria. The infection strategy of many Xanthomonas strains is based on transcription activator-like effectors (TALEs), which are secreted into the host cells and act as transcriptional activators of plant genes that are beneficial for the bacteria.The modular DNA binding domain of TALEs contains tandem repeats, each comprising two hyper-variable amino acids. These repeat-variable diresidues (RVDs) bind to their target box and determine the specificity of a TALE.All available tools for the prediction of TALE targets within the host plant suffer from many false positives. In this paper we propose a strategy to improve prediction accuracy by considering the epigenetic state of the host plant genome in the region of the target box.

Results
To this end, we extend our previously published tool PrediTALE by considering two epigenetic features: (i) chromatin accessibility of potentially bound regions and (ii) DNA methylation of cytosines within target boxes. Here, we determine the epigenetic features from publicly available DNase-seq, ATAC-seq, and WGBS data in rice.We benchmark the utility of both epigenetic features separately and in combination, deriving ground-truth from RNA-seq data of infections studies in rice. We find an improvement for each individual epigenetic feature, but especially the combination of both.Having established an advantage in TALE target predicting considering epigenetic features, we use these data for promoterome and genome-wide scans by our new tool EpiTALE, leading to several novel putative virulence targets.

Conclusions
Our results suggest that it would be worthwhile to collect condition-specific chromatin accessibility data and methylation information when studying putative virulence targets of Xanthomonas TALEs.
Spousal and living related kidney transplantation: our center experience
Authors: Ozgen Utku , Ozban Murat , Birsen Onur , Yilmaz Sevda , Dursun Belda , Ceri Mevlut , Eker Mesut , Aydin Huseyin Cagatay 
Published: December 2021

Abstract
Background
Kidney transplantation is the most preferred type of renal displacement therapy for end stage renal disease (ESRD) patients. More patients developed ESRD. The most important source is the donations from unrelated spouses. In this study, we aimed to compare the transplantation data obtained from the spouses of the patients with the transplantation data obtained from other relatives.

Methods
The data including 167 living kidney transplantations performed between January 2006 and December 2019 were retrospectively collected. The patients were divided into two groups; spousal donor group (n: 53) and living-related donor group (n: 114).

Results
There was no significant difference in delayed graft function in both groups. There were no patients with acute rejection proven by biopsy or considered biochemically in the spousal donor group. With regard to 3-year results in the living-related donor group the patient survival rate was 100%, while it was 98.2% in terms of graft survival.

Conclusions
In conclusion, similar patient and graft survival rates between spousal donor kidney transplantation and living-related kidney transplantation has made spousal donor kidney transplantation, with possible problems in terms of tissue compatibility, an acceptable alternative to donor supply.
The type of gastrectomy and modified frailty index as useful predictive indicators for 1-year readmission due to nutritional difficulty in patients who undergo gastrectomy for gastric cancer
Authors: Osaki Tomohiro , Saito Hiroaki , Miyauchi Wataru , Shishido Yuji , Miyatani Kozo , Matsunaga Tomoyuki , Tatebe Shigeru , Fujiwara Yoshiyuki 
Published: December 2021

Abstract
Background
Patients who undergo gastrectomy for gastric cancer (GC) are likely to have nutritional difficulty after surgery. Readmission due to nutritional difficulty is common in such patients. Thus, in this study, we aim to identify the predictive indicators for readmission due to nutritional difficulty in patients who underwent gastrectomy for GC.

Methods
We retrospectively reviewed surgical outcomes in 516 consecutive patients who underwent gastrectomy for GC.

Results
The readmission rate within 1 year was 13.8%. Readmission due to nutritional difficulty was observed in 20 patients (3.9%); it was determined as the second leading cause of readmission. Multivariate analysis revealed that the type of gastrectomy and the modified frailty index (mFI) were independent predictive indicators of readmission due to nutritional difficulty. Patients were assigned 1 point for each predictive indicator, and the total points were calculated (point 0, point 1, or point 2). The readmission rates due to nutritional difficulty were 1.2%, 4.7%, and 11.5% in patients with 0, 1, and 2 points, respectively (P = 0.0008).

Conclusions
The readmission rate due to nutritional difficulty was noted to be high in patients who underwent total or proximal partial gastrectomy with high mFI. Intensive follow-up and nutritional support are needed to reduce readmissions due to nutritional difficulty. Reduced readmission rates can improve patient quality of life and reduce medical costs.
Oral and dental manifestations of celiac disease in children: a case–control study
Authors: Alsadat Farah A. , Alamoudi Najlaa M. , El-Housseiny Azza A. , Felemban Osama M. , Dardeer Faisal M. , Saadah Omar I. 
Published: December 2021

Abstract
Background
Celiac disease (CD) is an immune-mediated enteropathy. CD may also involve complications with the oral cavity, which can result in various dental and oral pathologies. There are currently a limited number of studies on the oral manifestation of CD. This study aims to compare the oral manifestations of children with CD against healthy controls in Saudi Arabia.

Materials and methods
This study includes 208 children aged 6–14 years, distributed equally into CD patients and healthy controls. A parent completed and validated the interview questionnaire, which included the child's personal information and medical history. A dental examination was undertaken to measure possible recurrent aphthous stomatitis (RAS), dental enamel defects (DEDs), dental caries experience, and dental malocclusion. Data were analyzed using descriptive statistics and bivariate and multivariate analysis.

Results
Two hundred and eight participants were included (104 CD patients and 104 controls). The mean age for CD patients was 10.67 ± 2.39 years and 10.69 ± 2.36 for the healthy controls. CD children had more RAS than controls (42.3% vs. 15.4%, P < 0.001) (OR = 4.03, 95% CI = 2.09–7.81) and more DEDs than healthy controls (70.2% vs. 34.6%, P < 0.001) (OR = 4.45, 95% CI = 2.48–7.97). No significant difference was found in the frequency of malocclusion between cases and controls.

Conclusion
Saudi Arabian children with CD had a greater number of clinical findings of RAS and DEDs than healthy controls. Pediatric dentists should consider the possibility of CD in child patients presenting with RAS or DEDs.
Factor structure and internal reliability of breast cancer screening Champion’s Health Belief Model Scale in Yemeni women in Malaysia: a cross-sectional study
Authors: Noman Sarah , Shahar Hayati Kadir , Rahman Hejar Abdul , Ismail Suriani , Aljaberi Musheer A. , Abdulrahman Muzaphar N. 
Published: December 2021

Abstract
Background
The reliability and validity of the Champion’s Health Belief Model Scale (CHBMS) used in assessing the belief of women regarding breast cancer (BC) and breast cancer screening (BCS) have been examined on various populations. However, the use of this tool has not been adequately assessed for its validity in ethnic minorities. This study assessed the validity and reliability of CHBMS by analyzing the factor structure and internal reliability of the factors among Yemeni women in Malaysia.

Methods
A survey was conducted among 103 female teachers from 10 schools. SPSS version 22.0 was utilized in analyzing the data. Descriptive statistics were computed for the socio-demographic characteristics. The Cronbach’s alpha coefficients were used in assessing the internal reliability. The Exploratory Factor Analysis (EFA) was used to analyze the factor structure of the translated items. Parallel analysis was performed to determine the number of factors accurately.

Results
The alpha coefficients of the factors had acceptable values ranging between 0.76 and 0.87. The factor analysis yielded six and five factors for breast self-examination (BSE) and mammography (MMG), with a total explained variance of 47.69% and 52.63%, respectively. The Kaiser–Meyer–Olkin (KMO) index values of 0.64 and 0.72, and the Bartlett’s Test of Sphericity (P = 0.0001) for BSE and MMG, respectively, verified the normality distribution and the adequacy of the sample size for EFA. All the items on each factor were from the same construct that were consistent with the number of factors obtained in the scale development study. The items achieved adequate factor loadings that ranged between 0.47 and 0.88.

Conclusions
The translated version of the CHBMS is a validated scale used in assessing the beliefs related to BC and BCS among Yemeni women living in Malaysia. Healthcare workers could use the scales to assess women’s beliefs on BC and BCS. This instrument could be used to test the effectiveness of the intervention programs.