bluuebunny/crossref_metadata_2025_split huggingface dataset:
P14.74 Grade II and III pleomorfic xanthoastrocitoma: a monocentric, retrospective analysis
Authors: Gaviani P , Simonetti G , Farinotti M , Redaelli V , Botturi A , Pollo B , Legnani F , Pinzi V , Silvani A 
Published: September 2021

Abstract

BACKGROUND
Pleomorphic xanthoastrocytoma (PXA) represent an astrocytic neoplasm that is typically well circumscribed and can have a relatively favorable prognosis. Tumor progression to anaplastic PXA (WHO grade III), however, is associated with a more aggressive biologic behavior and worse prognosis. The factors that drive anaplastic progression are largely unknown. The activating BRAF mutation is a genetic alteration that could be present in both PXA and anaplastic PXA; Identification of the mutation can be important as BRAF V600E mutant protein could be targeted therapeutically by small molecule inhibitors of both RAF and MEK. The low frequency of these tumors has fostered heterogeneity of therapeutic approaches, particularly in adult patients. We performed a monocentric, retrospective study on adult patients with a PXA diagnosis treated by our Institution, in order to search for markers of diagnosis and prognosis.

MATERIAL AND METHODS
All consecutive patients older than 18 years with a histological diagnosis of a primary grade II and III pleomorphic xanthoastrocytoma operated and treated by our Institution from 2011 to 2021 were consecutively and retrospectively included in the study. All pathological diagnoses and PXA cases were reviewed according to the WHO classification. Histological and molecular characteristics, including BRAF mutation status, as well as clinical data, treatment modalities, and patient outcome were analyzed and described.

RESULTS
21 patients were included, 10 males and 11 females, with a median age of 40 years old (range 18–66). In 10 patients the histology showed an anaplastic PXA and in 11 patients a grade II tumor. Genetic features, including IDH status were available to all patients and BRAF mutation study was available in 8/10 anaplastic PXA. All patients underwent main surgery. Anaplastic features were associated with minimal PFS, whereas BRAF mutation tended to be associated with a better PFS.

CONCLUSION
Anaplastic features and BRAF mutation can lead to identify subgroups with distinct prognosis. These results should be validated in a larger and prospective study.
P14.79 Differentiation of treatment-related changes from tumor progression following brachytherapy in patients with WHO II and III gliomas using FET PET
Authors: Bauer E K , Werner J , Brunn A , Deckert M , Ruess D , Ruge M , Celik E , Fink G R , Langen K , Galldiks N 
Published: September 2021

Abstract

BACKGROUND
Following brachytherapy, the differentiation of radiation-induced changes (e.g., radiation necrosis) from actual tumor progression using MRI is challenging. To overcome this diagnostic uncertainty, we evaluated the diagnostic value of O-(2-[18F]-fluoroethyl)-L-tyrosine (FET) PET in glioma patients treated with brachytherapy.

MATERIAL AND METHODS
From 2006–2019, we retrospectively identified WHO grade II or III glioma patients (i) treated with brachytherapy using Iodine-125 seeds, (ii) equivocal or progressive MRI findings inside the radiation field, and (iii) additional FET PET imaging for diagnostic evaluation. Static FET PET parameters such as maximum and mean tumor-to-brain ratios (TBR) and dynamic FET PET parameters (i.e., time-to-peak, slope) were obtained. Diagnostic performances were calculated using receiver operating characteristic curve analyses and Fisher’s exact test. Diagnoses were confirmed histologically or clinicoradiologically.

RESULTS
Following brachytherapy, suspect MRI findings occurred after a median time of 33 months (range, 5–111 months). In 10 of 21 patients (WHO grade II, n=5; WHO grade III, n=16), treatment-related changes were diagnosed. The best diagnostic performance for identification of treatment-related changes was obtained using maximum TBRs (threshold &lt;3.20; accuracy, 86%; sensitivity, 100%; specificity, 73%; P=0.007). Mean TBRs reached an accuracy of 76% (threshold &lt;2.05; sensitivity, 89%; specificity, 64%; P=0.010). Dynamic PET parameters did not reach statistically significant results.

CONCLUSION
Our data suggest that static FET PET parameters add valuable diagnostic information to diagnose radiation-induced changes in glioma patients treated with brachytherapy.
P14.88 Management of primary CNS lymphomas. Experience of 32 cases
Authors: Simonyan A S , Lepsveridze L T , Simavonyan Z K , Davtyan A A , Mikhaylova A D , Tyurnikov V M , Gushcha A O 
Published: September 2021

Abstract

BACKGROUND
Lymphomas (primary and secondary) are rare tumors of the central nervous system. They can involve both the supratentorial areas and the posterior cranial fossa. Modern management of patients with suspected CNS lymphoma should include a stereotactic or navigation-guided biopsy and subsequently carrying out chemotherapy and, in rare cases, radiosurgery.

MATERIAL AND METHODS
We analyzed our experience of the diagnosis and treatment of PCNSL. Our work included 32 patients with PCNSL. The study did not include patients with suspected CNS lymphoma, according to MRI data, in whom the diagnosis was not confirmed after biopsy.

RESULTS
Thirty patients underwent biopsy (20 - navigation guided, 1 - open, 9 - “burr hole”) with preliminary intraoperative histological verification. Gross total resection was performed in 2 cases since, according to preoperative MRI data, it was assumed that the patient had glial tumors. Postoperative histological examination confirmed the diagnosis of CNS lymphoma in all cases. Subsequently, after detailed histological and immunohistochemical studies, 30 patients underwent intra-arterial chemotherapy or high-dose chemotherapy according to NCCN protocols. Palliative treatment was recommended in 2 cases due to acute deterioration of patients. In our work, we would like to present a diagnostic algorithm and treatment regimens used in the management of our patients.

CONCLUSION
In the treatment of CNS lymphomas, careful histological verification is required, which is possible if several key points are performed - discontinuation of dexamethasone at least 24 hours before the biopsy, MRI for intraoperative neuronavigation after discontinuation of dexamethasone, intraoperative preliminary histological verification. In our opinion, complete removal of the tumor is possible if there are no risks of developing a persistent neurological deficit. Various methods of opening the blood-brain barrier are currently used, which can significantly reduce the effective dosage of drugs and, accordingly, the side effects. Further research is needed to determine the dependence of the prognosis of the disease on the type of surgery (biopsy or resection).
P14.89 Papillary tumor of the pineal region: three cases from a single institution
Authors: Yorio F , Ujhelly I J , Calabrese B , Cervio A , Muggeri A 
Published: September 2021

Abstract

BACKGROUND
Papillary tumors of the pineal region are highly unusual lesions of unknown incidence. These are neuroepithelial tumors with papillary and solid areas. There is no standardized treatment because of the difficulty to make randomized prospective trials due to its rarity. We report three patients with papillary tumor of the pineal region.

MATERIAL AND METHODS
Retrospective review of the clinical records of patients with papillary tumor of the pineal region at a tertiary neurological center in Buenos Aires, Argentina was done between 2/2012-04/2021. Clinical characteristics, imaging, pathology, treatment and follow-up data were obtained.

RESULTS
Two patients were male and one female. All three patients were adults, two in the fourth decade of life and one in the seventh. Clinical presentation included headache along with either visual symptoms, gait disturbance, or both. Imaging workup included brain and spinal magnetic resonance imaging, finding expanding lesions in the pineal region, hyperintense in FLAIR/T2 sequences, with gadolinium enhancement in T1 with contrast sequence and variable degrees of hydrocephalus. Spinal lesions were not found in these patients. Cerebrospinal fluid cytology was negative in all cases. Tumor biopsy was the initial approach in all cases. Two patients underwent an initial third ventriculostomy procedure but all were submitted to a supracerebellar infratentorial approach for major resection. Posterior treatment included chemoradiotherapy with temozolomide. One patient had a distant recurrence after seven years with and remained with stable disease for two more years, and the other two patients are under control with no recurrence after 2 and 2.5 years respectively.

CONCLUSION
Papillary tumors in the pineal regions are aggressively treated as recurrence is very frequent regarding previous reports (&gt; 70%). Total resection is the only predictive factor associated to better outcome, however, more information is needed in order to achieve treatment consensus.
P14.92 Combination of Tumor Treating Fields and CCNU chemotherapy as valuable option for the treatment of unresectable progressive glioblastoma: A case presentation
Authors: Mergen E , Landrock S , Chizzali B 
Published: September 2021

Abstract

BACKGROUND
Tumor Treating Fields (TTFields) are low intensity (1–3 V/cm) alternating electric fields with an intermediate frequency of 100–300 kHz. TTFields in addition to temozolomide (TMZ) after radiochemotherapy according to Stupp significantly increased progression-free survival (PFS), overall survival (OS) and long-term survival rates in patients with newly diagnosed glioblastoma (GBM) in the multicenter phase 3, EF-14 trial. Post-hoc analysis of the trial revealed that TTFields in combination with second-line therapy after first recurrence significantly prolonged OS compared to second-line therapy alone. We here report on a GBM patient with partial resection showing regressive volume of unresected, previously progressive tumor under combination therapy of TTFields and second-line CCNU chemotherapy.

MATERIAL AND METHODS
In November 2018, MRI of a 59-year-old female patient revealed a large heterogeneous space-occupying lesion in the left occipital region with clearly contrast-enhanced margin, perifocal edema and two smaller contrast-enhancing lesions in the splenium corporis callosi and right of the trigonum suboccipitale. While the tumor in the left occipital region was completely resected, lesions in the right hemisphere remained unresected. Histopathology identified MGMT-promoter methylated GBM. The patient received concomitant radiochemotherapy followed by adjuvant TMZ. However, after three cycles, the unresected tumor progressed, TMZ was exchanged by procarbazine/CCNU and TTFields therapy was initiated. After two cycles, chemotherapy was changed to only CCNU due to further progression while TTFields therapy was continued.

RESULTS
One year after diagnosis, MRI showed no contrast-enhancing tissue in the resection cavity and regressive perifocal edema while lesions in the right hemisphere remained stable. Under tolerable hematotoxicity CCNU was continued together with TTFields, to which the patient showed high adherence far beyond the suggested threshold of 75%. Control examination in February 2020 reported regressive tumor volume in the right hemisphere under CCNU/TTFields therapy. Until January 2021, the tumor regressed even further without the detection of new lesions. The patient is currently continuing CCNU together with TTFields, achieving an average usage of 84% over the last twelve months.

CONCLUSION
In the presented case, the combination of TTFields and CCNU was feasible and safe in progressive GBM. The patient showed radiological response and local tumor regression under the combination therapy, whereas the tumor had previously progressed under chemotherapy alone. In conclusion, the addition of TTFields to chemotherapy is a valuable treatment option to improve clinical and radiological outcome of patients with progressive GBM. This example of TTFields use in clinical practice encourages its use beyond tumor progression.
Sound Art as Locative Narrative
Authors: Whittaker Emma 
Published: September 2021

Abstract
Locative narrative is a form of mobile sound art that sites stories in diverse urban and rural situations. The live ambient sounds, particular to a street, building, or hilltop, are an essential element of the work. This chapter argues that these relations between sounds and things are multistable. This chapter first contextualizes locative narrative and then puts forward an experimental pragmatist framing of experience and perceiving, drawing upon the neuroscience term, multistability. A four-fold framework of multistability is introduced: (1) changing the relations to perceptual and imaginary objects; (2) influencing the value of belief; (3) influencing the value of fiction and the representation of perceptual objects; and (4) changing the relations to the experiences of perception and misperception. This theory is an important contribution to sound art because it demonstrates how changing the relations between sensory perception, language, and belief can reshape what is felt and experienced.
Echo’s Embrace
Authors: Crow Frances 
Published: September 2021

Abstract
This chapter seeks to bring together two relationships, the first, between science and art in the West during the period of modernity and the second between the fabric of sound-space and the rendering of Echo. Following the dis-articulation of sound-space pre-empted by Sabine’s equation for reverberation (and its adoption by the acoustic profession) I draw together the various traits of echo as mythic figure, as disembodied voice and as acoustic phenomenon to consider the re-articulation of sound-space through sound-art practice. This chapter offers to artists, acousticians, and architects an alternative mapping of the history of acoustics by drawing the reader’s attention to the work of Athanasius Kircher. I suggest that he is as much the father of the acoustic arts as Mersenne, his contemporary, is the father of the acoustic sciences.
Sonic sense
Authors: Voegelin Salomé 
Published: September 2021

Abstract
This chapter aims to set up the context for novel engagements in notions of sense, knowledge, and meaning via sound. Sound is introduced as material as well as concept, and listening is considered at once as strategy and as expanded method to engage and challenge existing notions of prehension, interpretation, and significance, and to query their rationale. The suggestion is that the sonic offers itself to experience not as meaning but as a challenge to the making of sense, and that consequently through listening we can reach a different sense, that is plural and includes what we did not expect to know. These ideas are developed by listening to Christof Migone’s work HitParade (NewYork) (2012), a group performance which sounds bodies, surfaces, and microphones through their shared rhythm, and to Jana Winderen’s The Wanderer (2015), a field recording of zooplankton and phytoplankton between the North Pole and the Equator.
Intimate Listening
Authors: Paterson Mark 
Published: September 2021

Abstract
Space and proximity are entangled in the idea of listening. First, I set up the relationship between intimacy and listening through Jean-Luc Nancy. Second, I consider highlights of nineteenth-century discoveries in the history of physiology and functional anatomy of the cochlea and the labyrinth of the inner ear, those spaces and chambers whose non-auditory function was determined only through painstaking experimentation. This leads to Michel Serres’ consideration of the interior and exterior noise of the body, including a proprioceptive hearing of intimate personal sounds through skin, bone, feet, and muscle, a bodily interior that resonates like boxes (boîtes). Third, I apply this shared intimacy of listening to a few examples of sound art that explore resonances across sensory modalities and bodily spaces, including the work of Jacob Kirkegaard, who employs the phenomenon of otoacoustic emission (OAE), and Adam Basanta.
Sound Art: Hearing in Particular
Authors: Drever John L. 
Published: September 2021

Abstract
Extoling and promoting listening is deeply ingrained in sound art practice and discourse, even on occasion its raison d’être, where listening is understood as a wholly congenial, benign activity. This can be seen through the routine use of affirmative tropes such as, through listening we: connect, locate, are embodied, discern, are immersed or enveloped. And through specific listening methods such as Deep Listening, we are offered ‘expand[ed] consciousness to the whole space/time continuum of sound/silences’ (Oliveros, 2005, p. xxiv). Refocusing from the act of listening to the audiological—the mechanisms related to the sense of hearing—from the findings of the author’s recent research, in particular his review on the noise impact of high-speed hand dryers (Drever, 2013), the author feels obliged to assert that the contrary is a reality for many—hearing, from time to time or incessantly: perturbs, isolates, excludes, disconnects, disembodies, and dislocates, hearing hurts! This will be familiar for those living with hyperacusis, misophonia, and phonophobia, but it can also be the case for those with particular hearing needs such as the partially sighted, hearing aid users or those with sensitive hearing such as infants and ASD. Bringing audiology into the sphere of sound art, this chapter recognizes a prevailing sensitization of hearing in the culture at large, and proposes a paradigm for situating hearing that diverges from a singular, idealized, symmetrical model of hearing, the auraltypical, that has predominated. In its place, we are beginning to enjoy a fluidity and openness to diverse forms of hearing and sensitive hearers in sound art, on embracing the emerging agenda of auraldiversity.
‘And I Listened to the Whistlings and Patterings Outside’
Authors: Carlyle Angus 
Published: September 2021

Abstract
The notion of the wild is one that has developed a richer currency in recent years, simultaneously enrolled as a branding device for leisure activities and employed to account for the potential planetary consequences of a shift towards the Anthropocene. Noting parallel amplifications of wild sound in both the philosophical concept of the sublime and in the literary genre known as nature writing, this chapter critically accounts for the ways in which creative sound practices have deployed listening and recording to manifest the spatial parameters of the wild. These sound art practices are shown to reveal tensions in terms of any strictly demarcated border between the wild and the cultivated, in terms of the technical assemblages that are taken to the wild and that render what is heard there audible, and in terms of the wild as a space that is to be accessed through solitary, silent and arduous effort.
Maternal Aggression
Authors: Ottesen Vibeke 
Published: September 2021

Abstract
This chapter explores evolutionary psychological (EP) perspectives on maternal aggression, focusing on physical aggression, both lethal and nonlethal. It argues that the psychological mechanisms underpinning such aggression held an adaptive function to our foremothers. If such mechanisms formerly did hold an adaptive function, then maternal aggression should not be expected to be a random event, nor necessarily caused by pathology. Rather, the risk factors and characteristic traits of maternal aggression should follow an ancestrally adaptive and evolutionary logic. In which case, it should be a predictable phenomenon on a societal level. And as the chapter presents, the theoretical understanding of maternal aggression that EP perspectives offer has allowed for the successful prediction of risk factors and characteristic traits for such aggression. The chapter reviews these risk factors and traits, along with the theoretical reasoning the predictions are based on and the cross-cultural empirical support for their existence.
Maternal Investment in Adolescent Daughters and Sons
Authors: Lewis Mary B. Eberly , Hoenig Trinity 
Published: September 2021

Abstract
This chapter reflects on maternal investment in adolescent daughters and sons. The focus of maternal investment necessarily changes as a function of the ontological maturity of adolescent sons and daughters. As most sexually mature youth continue to live with parents, mothers’ investments channel youth toward adaptive trajectories given the opportunities and constraints of the local ecology. The nature of childrearing shifts to a greater emphasis on preparing daughters and sons for socio-competitive success; that is, providing resources, particularly those that increase adult knowledge and skills, and protecting offspring from their own adventurousness while learning occurs. Through this focus, mothers facilitate the reproductive success of offspring.
Paternal Relationships With Sons and Daughters
Authors: Nikiforidis Lambrianos 
Published: September 2021

Abstract
This chapter examines paternal relationships with sons and daughters. Identity drives investment (and parental investment in particular), because people invest in that which aligns with their identity. And biological sex drives identity. These two ideas combined imply that a parent-offspring match in biological sex can influence parental favoritism in a systematic manner, an idea supported by recent empirical studies. This parental bias of concordant-sex favoritism can have broad implications, outside the context of the traditional family structure. In single parent or same-sex parent households, the consequences of this bias can be even stronger, because there would not be an opposite-direction bias from the other parent to even things out. This favoritism could have even broader ramifications, entirely outside the context of the family. On the one hand, whenever social norms dictate that men should control a family’s financial decisions, then sons may systematically receive more resources than daughters. This asymmetry in investment would then result in ever-increasing advantages that persist over time. On the other hand, if women are a family’s primary shoppers, this can manifest in subtle but chronic favoritism for daughters.
Politics and Parenting
Authors: Kerry Nicholas , Murray Damian R. 
Published: September 2021

Abstract
This chapter assesses how parenthood may functionally influence political attitudes. Becoming a parent is a keystone life event that has numerous psychological and physiological implications. There are several theoretical reasons to predict a functional relationship between parenthood (as well as individual differences in parenting motivation) and socially conservative attitudes, primarily related to an increased sensitivity to threat and a reduced interest in short-term mating. Moreover, initial work has found correlational, mediational, and experimental support for a functional and causal relationship between parenting and increased social conservatism and out-group prejudice. However, many unanswered questions remain, as do multiple fruitful avenues for future research.
Parental Influence and Sexual Selection
Authors: Apostolou Menelaos 
Published: September 2021

Abstract
This chapter addresses how the genetic relatedness between parents and their children results in the two parties having converging as well as diverging interests. In the domain of mating, these interests, along with other factors such as the trade-offs inherent in mating, give rise to an opportunity cost of free mate choice: Parents have much to lose if they allow their children to exercise choice freely. This opportunity cost provides a strong incentive to parents to influence their children’s mate choices. In preindustrial societies, parents manage to exercise direct control, which is predominantly manifested in the institution of arranged marriage. In postindustrial societies, parents exercise influence indirectly through manipulation. Ultimately, parental influence over mating gives rise to a sexual selection force, namely parental choice, which may be unique to the human species.