bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sebaran Mangrove di Desa Bumiharjo Kecamatan Keling Kabupaten Jepara
Authors: Suryono Suryono , Taufiq-SPJ Nur , Pratikto Ibnu , Ario Raden 
Published: February 2021

Kabupaten Jepara memiliki potensi wilayah pesisir dengan panjang garis pantai 81,6 km. Mangrove sebagai sabuk pantai hijau memiliki sebaran di setiap kecamatan pesisir. Salah satu lokasi sebaran mangrove di pesisir Jepara berada di desa Bumiharjo Kecamatan Keling. Identifikasi potensi luasan lahan serta sebaran mangrove adalah salah upaya mengetahui potensi sumberdaya pesisir. Metode penelitian yang digunakan adalah overlay peta RBI dan peta satelit landsat 8 guna mengetahui lokasi serta luasan sebaran mangrove di lokasi penelitian.Selanjutnya dilakukan investigasi ekologi mangrove dengan Survei Lapang guna mengetahui distribusi dan kelimpahan mangrove. Hasil penelitian menunjukan bahwa hutan mangrove dilokasi penelitian adalah seluas 4,75 Ha. Hasil identifikasi komposisi jenis mangrove ditemukan sebanyak 6 spesies mangrove yaitu: Avicennia marina, Rhizophora apiculata, Rhizophora stylosa, Rhizophora mucronata, Soneratia alba, serta Soneratia muconata. Kerapatan rata-rata vegetasi mangrove berkisar antara 4000 – 10.000 individu/ha. Tegakan mangrove memiliki tinggi batang 5-6 meter, diameter batang berkisara antara 4,3- 5,0 cm. Kerapatan mangrove didominasi oleh Rhizophora mucronata. dengan kerapatan paling dominan adalah semai (Sapling). Hal ini menunjukan bahwa mangrove yang ada di desa Bumiharjo Kecamatan Keling kabupaten Jepara adalah dominan mangrove hasil replant. Jepara Regency has a potential coastal area with a coastline length of 81.6 km. Mangroves as coastal green belts have distribution in each coastal district. One of the mangrove distribution locations on the coast of Jepara is in the village of Bumiharjo, Keling district. Identification of the potential land area and the distribution of mangroves is an effort to determine the potential of coastal resources. The research method used is an overlay RBI map and satellite map Landsat 8 to determine the location and extent of the distribution of mangroves in research locations. Subsequently carried out an investigation of mangrove ecology with a Field Survey (Ground Truth) to determine the distribution and abundance of mangroves. The results showed that the mangrove forest in the study area was 4.75 Ha. The results of the identification of the composition of mangrove species were found as many as 6 species of mangroves, namely: Avicennia marina, Rhizophora apiculata, Rhizophora stylosa, Rhizophora mucronata, Soneratia alba, and Soneratia muconata. the average density of mangrove vegetation ranges between 4000 - 10,000 individuals/ha. Mangrove stand has a stem height of 5-6 meters. the diameter of the stem is between 4.3 - 5.0 cm. Mangrove density is dominated by Rizophora mucronata. with the most dominant density is the seedling (Sapling). This shows that the mangroves on the coast of the Jepara district are replanted mangrove species. (rehabilitation).
Effect of age on serum metabolites of female Brahman crossbred cattle raised in an integration system of cattle-oil palm plantation in Central Kalimantan
Authors: Kristanto D. , Widiyono I. 
Published: February 2021

The study was aimed to evaluate the effect of age on the serum metabolite of female Brahman crossbred cattle raised extensively under the cattle-oil palm integrated system for 3 months. Thirty calves aged 3-6 months, 30 heifers aged 12-18 months, and 30 cows aged 48 months which were clinically healthy were selected and used in this study. Blood samples were collected from coccygeal vein. The serum was separated by centrifugation and stored at -20oC until the time of analysis. Blood samples were collected from coccygeal vein as much as 4 mL. Serum metabolites were determined using an autoanalyzer (The Roche/Hitachi Cobas 6000 analyzer). Serum concentration of ALB, Ca, P, Na, K, and Cl in calves were higher than heifers and cows (P<0.05), while serum creatinine, total protein, blood urea nitrogen (BUN) and globulin concentration in cows were higher than those ofcalves (P<0.05). Serum glucose concentration in calves and heifer was higher than that in cows (P<0.05). It could be concluded that the age factor must be considered in the interpretation of the results of the examination of the serum metabolites of Brahman crossbred cattle raised extensively in oil palm plantations.
The physical characteristics of cheese made of milk, colostrum and both during the ripening
Authors: Astuti F. D. , Setyawardani T. , Santosa S. S. 
Published: February 2021

This study aimed to understand the physical characteristics of cheese made of cow milk, colostrum, and milk+colostrum ripened for 20 days. Two factors in this study were cheese made of three materials: A (100% cow milk), B (50% cow milk + 50% colostrum) and C (100% colostrum), and ripening time, i.e. 0, 10, and 20 days. The process of cheese production started by heating the raw material, followed by decreasing the temperature, incorporating kefir as the starter. The next step was and the rennet and re-incubate the mixture for one hour until the fluid became solid granules, then the granules were filtered and pressed. The cheese was stored at a low temperature (4-8oC) according to each treatment. Each combination was repeated three times. The physical properties of cheese examined in this study were color, texture, pH, and microstructure. The result showed that the raw materials of cheese would produce different cheese colours in terms of lightness (L*), yellowness (b*), and whiteness index (WI) as well as cheese texture (hardness and gumminess). Also, ripening time would affect the hardness, springiness gumminess, chewiness, L*, a*, and WI of cheese. Colostrum added in cheesemaking has increased both yellowness and cavities in the microstructure.
New-onset diabetes after kidney transplantation revealing HNF1B-associated disease
Authors: Lopes Ana M , Teixeira Sofia 
Published: February 2021

Summary
Molecular alterations of the transcription factor hepatocyte nuclear factor 1B (HNF1B) are associated with systemic disease, with kidney disease and maturity-onset diabetes of the young (MODY) as the most characteristic manifestations. Other features comprise pancreatic exocrine insufficiency, liver and biliary anomalies, and genital tract malformations. HNF1B-associated disease is clinically heterogeneous, and therefore the diagnosis is challenging. The authors describe the case of a 19-year-old man with new-onset diabetes after kidney transplantation (NODAT). The kidney disease presented during fetal life as bilateral hyperechogenic kidneys. Renal function progressively deteriorated during childhood, and at the age of 19, the patient was submitted to a living-kidney transplant. Two weeks after transplant, NODAT developed. Given the young age and normal body weight, NODAT was unexpected, and the possibility of HNF1B-associated disease was considered. Screening for mutations in HNF1B was undertaken, and a known mutation was found. As this case highlights, HNF1B-associated disease should be considered when NODAT unexpectedly develops in young kidney transplant recipients with a suggestive renal disease.

Learning points:

HNF1B anomalies are associated with systemic disease, including kidney disease, diabetes mellitus, pancreatic exocrine insufficiency, liver test abnormalities and genital tract malformations.

Phenotype is variable and there are no pathognomonic manifestations, but kidney disease appears to be the most common feature and diabetes the most frequent extra-renal phenotype.

Spontaneous gene alterations are common, and the lack of family history should not exclude the diagnosis.

HNF1B defects should be considered when NODAT develops in a young adult kidney transplant recipient with a suggestive kidney disease and without extensive risk factors for diabetes.

The most appropriate treatment for HNF1B-associated diabetes is not established, but immunosuppressive therapy superimposed on a beta-cell dysfunction seems to determine the need for insulin therapy after a variable period.

Immunosupressive regimens free of calcineurin inhibitors should be considered in patients with HNF1B-associated disease to minimize the risk of developing NODAT.
Transcriptome wide association studies: general framework and methods
Authors: Xie Yuhan , Shan Nayang , Zhao Hongyu , Hou Lin 
Published: February 2021

BackgroundGenome‐wide association studies (GWAS) have succeeded in identifying tens of thousands of genetic variants associated with complex human traits during the past decade, however, they are still hampered by limited statistical power and difficulties in biological interpretation. With the recent progress in expression quantitative trait loci (eQTL) studies, transcriptome‐wide association studies (TWAS) provide a framework to test for gene‐trait associations by integrating information from GWAS and eQTL studies.ResultsIn this review, we will introduce the general framework of TWAS, the relevant resources, and the computational tools. Extensions of the original TWAS methods will also be discussed. Furthermore, we will briefly introduce methods that are closely related to TWAS, including MR‐based methods and colocalization approaches. Connection and difference between these approaches will be discussed.ConclusionFinally, we will summarize strengths, limitations, and potential directions for TWAS.
Mathematical modeling and optimal intervention of COVID‐19 outbreak
Authors: Biswas Saroj K , Ahmed Nasir U 
Published: February 2021

BackgroundThe COVID‐19 pandemic has become a formidable threat to global health and economy. The coronavirus SARS‐CoV‐2 that causes COVID‐19 is known to spread by human‐to‐human transmission, and in about 40% cases, the exposed individuals are asymptomatic which makes it difficult to contain the virus.MethodsThis paper presents a modified SEIR epidemiological model and uses concepts of optimal control theory for analysis of the effects of intervention methods of the COVID19. Fundamentally the pandemic intervention problem can be viewed as a mathematical optimization problem as there are contradictory outcomes in terms of reduced infection and fatalities but with serious economic downturns.ResultsConcepts of optimal control theory have been used to determine the optimal control (intervention) levels of i) social contact mitigation and suppression, and ii) pharmaceutical intervention modalities, with minimum impacts on the economy. Numerical results show that with optimal intervention policies, there is a significant reduction in the number of infections and fatalities. The computed optimum intervention policy also provides a timeline of systematic enforcement and relaxation of stay‐at‐home regulations, and an estimate of the peak time and number of hospitalized critical care patients.ConclusionThe proposed method could be used by local and state governments in planning effective strategies in combating the pandemic. The optimum intervention policy provides the necessary lead time to establish necessary field hospitals before getting overwhelmed by new patient arrivals. Our results also allow the local and state governments to relax social contact suppression guidelines in an orderly manner without triggering a second wave.
Testing the leanocentric locking‐point theory by in silico partial lipectomy
Authors: Wang Guanyu 
Published: February 2021

BackgroundThe lipostatic set‐point theory, ascribing fat mass homeostasis to leptin mediated central feedback regulation targeting the body’s fat storage, has caused a variety of conundrums. We recently proposed a leanocentric locking‐point theory and the corresponding mathematical model, which not only resolve these conundrums but also provide valuable insights into weight control and health assessment. This paper aims to further test the leanocentric theory.MethodsPartial lipectomy is a touchstone to test both the leanocentric and lipostatic theories. Here we perform in silico lipectomy by using a mathematical model embodying the leanocentric theory to simulate the long‐term body fat change after removing some fat cells in the body.ResultsThe mathematical modeling uncovers a phenomenon called post‐surgical fat loss, which was well‐documented in real partial lipectomy surgeries; thus, the phenomenon can serve as an empirical support to the leanocentric theory. On the other hand, the leanocentric theory, but not the lipostatic theory, can well explain the post‐surgical fat loss.ConclusionsThe leanocentric locking‐point theory is a promising theory and deserves further testing. Partial lipectomy surgeries are beneficial to obese patients for quite a long period.
Evaluation of renal cyst treatment using retroperitoneal laparoscopic decortication
Authors: Ho Ut Thanh , Dam Cuong Van , Le Nghiep Ke 
Published: February 2021

Introduction: Renal cyst is a common disease of the renal parenchyma. The management options include percutaneous aspiration with or without sclerotherapy, open surgery, and laparoscopic decortication of renal cyst. Laparoscopic renal cyst decortication is a safe and effective alternative with a high success rate. Objectives: Evaluation of renal cyst treatment by retroperitoneal laparoscopic decortication.
Methods: This was a prospective study of patients with asymptomatic renal cyst size greater than 60 mm or symptomatic renal cyst size less than 60 mm in their greatest dimension. These patients underwent retroperitoneal laparoscopic decortication and were admitted at the University Hospital, Can Tho General Hospital (Viet Nam), and Can Tho Central General Hospital (Viet Nam), from September 2018 to May 2020. Renal cysts were localized and characterized by ultrasonography and computed tomography (CT). Symptomatic success rate, radiologic success rate, and complication of procedure were noted. Each patient was reassessed with clinical and ultrasonography examinations at 3 months postoperatively.
Results: 33 patients underwent retroperitoneal laparoscopic cyst decortication; this included 11 males (33.3%) and 22 females (66.7%). The mean age of patients was 58.48 ± 9.36 years. Flank pain was a common clinical symptom at presentation in all patients. Most of the cysts were located in the left kidney (39.4%), in the lower pole (54.6%), and in a single cyst (87.9%). The mean cyst diameter was 80.09 ± 27.03 mm. Cysts were classified I with the Bosniak classification. The mean operative time was 69.39 ± 16.94 minutes. Operative time in patients with cyst diameter ≥ 60 mm was statistically significantly longer than in patients with cyst diameter < 60 mm (p = 0.004). The mean hospital stay time was 8.24 ± 2.84 days. Symptomatic success was achieved in 90.1% of patients and radiographic success on ultrasonography was achieved in 84.8%. The operation was successfully completed by laparoscopy in all cases.
Conclusion: Retroperitoneal laparoscopic cyst decortication is effective for the treatment of renal cysts. The operation was successfully completed via laparoscopy in all cases.
The Secondary Consequences of the COVID-19 Pandemic in Hospital Pediatrics
Authors: Diskin Catherine , Orkin Julia , Agarwal Tanvi , Parmar Arpita , Friedman Jeremy N. 
Published: February 2021

BACKGROUND AND OBJECTIVES:
The coronavirus disease (COVID-19) pandemic has broad implications for children and families. Particular attention has been paid to delays in accessing timely pediatric care leading to unintended morbidity. In this study, we aim to describe the broader spectrum of unintended negative consequences for pediatric patients and families due to recent health care and societal changes.

METHODS:
All full-time doctors, dentists, and nurse practitioners working at a tertiary care children’s hospital in Canada were surveyed every 2 weeks throughout the initial phase of the COVID-19 pandemic to identify clinical cases in which they perceived a negative outcome associated with hospital or societal changes as a result of the COVID-19 pandemic. Analysis followed a qualitative case series methodology using a narrative synthesis approach to determine similarities and associated themes.

RESULTS:
One hundred and forty-one clinicians, representing 26 hospital divisions, reported 57 unique cases in the first 6 weeks of the study. Thematic analysis of the first 50 reported cases was used to identify 6 primary themes focusing on health care quality domains as described by the Agency for Healthcare Research and Quality (safe, effective, patient-centered, timely, efficient, and equitable care).

CONCLUSIONS:
In this preliminary case analysis, we describe the broad social and clinical impact of COVID-19 on hospitalized pediatric patients and their families. These themes highlight the unintended consequence on families, siblings, disease diagnosis, and hospital-based care provision. Recognition and understanding of the broad implications of the COVID-19 pandemic are necessary as we strive to deliver safe, high-quality, family-centered pediatric care in this new era.
A Changing Landscape: Exploring Resident Perspectives on Pursuing Pediatric Hospital Medicine Fellowships
Authors: Chandrasekar Hamsika , White Yasmine N. , Ribeiro Claudio , Landrigan Christopher P. , Marcus Carolyn H. 
Published: February 2021

BACKGROUND:
Pediatric Hospital Medicine (PHM) was approved as a subspecialty in 2016. Perspectives of pediatric and combined pediatric residents regarding barriers and facilitators to pursuing PHM fellowships have not previously been assessed.

METHODS:
A survey to explore residents’ perspectives on PHM fellowships, with questions regarding demographics, likelihood of pursuing PHM after fellowship introduction, and influencing factors was distributed to pediatric and combined pediatric residents via program directors.

RESULTS:
The survey was distributed to an estimated 2657 residents. A total of 855 (32.2%) residents completed the survey; 89% of respondents had at least considered a career in PHM, and 79.4% reported that the introduction of the PHM fellowship requirement for subspecialty certification made them less likely to pursue PHM. Intent to practice in a community setting or only temporarily practice PHM, Combined Internal Medicine and Pediatric trainee status, and high student loan burden were associated with decreased likelihood of pursuing PHM (P &lt; .05). Most respondents reported that forfeited earnings during fellowship, family and student loan obligations, and perceived sufficiency of residency training discouraged them from pursuing PHM fellowship. Half of respondents valued additional training in medical education, quality improvement, hospital administration, research, and clinical medicine.

CONCLUSIONS:
Many survey respondents expressed interest in the opportunity to acquire new skills through PHM fellowship. However, the majority of respondents reported being less likely to pursue PHM after the introduction of fellowship requirement for board certification, citing financial and personal opportunity costs. Understanding factors that residents value and those that discourage residents from pursuing PHM fellowship training may help guide future iterations of fellowship design.
The Association of Seasonality With Resource Use in a Large National Cohort of Infants With Bronchiolitis
Authors: Andrews Christine , L. Maxwell Sarah , Kerns Ellen , McCulloh Russell , Alverson Brian 
Published: February 2021

OBJECTIVES:Examine the degree of seasonal variation in nonrecommended resource use for bronchiolitis management subsequent to publication of the American Academy of Pediatrics (AAP) 2014 guidelines.METHODS:We performed a multicenter retrospective cohort study using the Pediatric Health Information System database, examining patients aged 1 to 24 months, diagnosed with bronchiolitis between November 2015 and November 2018. Exclusions included presence of a complex chronic condition, admission to the PICU, hospital stay &gt;10 days, or readmission. Primary outcomes were use rates of viral testing, complete blood count, blood culture, chest radiography, antibiotics, albuterol, and systemic steroids. Each hospital’s monthly bronchiolitis census was aggregated into hospital bronchiolitis census quartiles. Mixed-effect logistic regression was performed, comparing the primary outcomes between bronchiolitis census quartiles, adjusting for patient age, race, insurance, hospitalization status, bacterial coinfection, time since publication of latest AAP bronchiolitis guidelines, and clustering by site.RESULTS:In total, 196 902 bronchiolitis patient encounters across 50 US hospitals were analyzed. All hospitals followed a similar census pattern, with peaks during winter months and nadirs during summer months. Chest radiography, albuterol, and systemic steroid use were found to significantly increase in lower bronchiolitis census quartiles, whereas rates of viral testing significantly decreased. No significant variation was found for complete blood count testing, blood culture testing, or antibiotic use. Overall adherence with AAP guidelines increased over time.CONCLUSIONS:Resource use for patients with bronchiolitis varied significantly across hospital bronchiolitis census quartiles despite adjusting for potential known confounders. There remains a need for greater standardization of bronchiolitis management.
Is Unplanned PICU Readmission a Proper Quality Indicator? A Systematic Review and Meta-analysis
Authors: Prutsky Gabriela J. , Padhya Dipti , Ahmed Ahmed T. , Almasri Jehad , Farah Wigdan H. , Prokop Larry J. , Murad M. Hassan , Alsawas Mouaz 
Published: February 2021

CONTEXT:
Unplanned PICU readmissions within 48 hours of discharge (to home or a different hospital setting) are considered a quality metric of critical care.

OBJECTIVE:
We sought to determine identifiable risk factors associated with early unplanned PICU readmissions.

DATA SOURCES:
A comprehensive search of Medline, Embase, the Cochrane Database of Systematic Reviews, and Scopus was conducted from each database’s inception to July 16, 2018.

STUDY SELECTION:
Observational studies of early unplanned PICU readmissions (&lt;48 hours) in children (&lt;18 years of age) published in any language were included.

DATA EXTRACTION:
Two reviewers selected and appraised studies independently and abstracted data. A meta-analysis was performed by using the random-effects model.

RESULTS:
We included 11 observational studies in which 128 974 children (mean age: 5 years) were evaluated. The presence of complex chronic diseases (odds ratio 2.42; 95% confidence interval 1.06 to 5.55; I2 79.90%) and moderate to severe disability (odds ratio 2.85; 95% confidence interval 2.40 to 3.40; I2 11.20%) had the highest odds of early unplanned PICU readmission. Other significant risk factors included an unplanned index admission, initial admission to a general medical ward, spring season, respiratory diagnoses, and longer initial PICU stay. Readmission was less likely after trauma- and surgery-related index admissions, after direct admission from home, or during the summer season. Modifiable risk factors, such as evening or weekend discharge, revealed no statistically significant association. Included studies were retrospective, which limited our ability to account for all potential confounders and establish causality.

CONCLUSIONS:
Many risk factors for early unplanned PICU readmission are not modifiable, which brings into question the usefulness of this quality measure.