bluuebunny/crossref_metadata_2025_split huggingface dataset:
Streamlined Multidisciplinary Work Flow Assesses Pipeline Slugging
Authors: Carpenter Chris 
Published: December 2021

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper OTC 30172, “A Streamlined Multidisciplinary Work Flow for Pipeline-Slugging Assessment,” by Jeff Zhang, Saurav Jha, and Tim Matuszyk, Wood, prepared for the 2020 Offshore Technology Conference Asia, originally scheduled to be held in Kuala Lumpur, 2–6 November. The paper has not been peer reviewed. Copyright 2020 Offshore Technology Conference. Reproduced by permission.
Free spans exist in subsea multiphase pipelines laid over undulating seabed profiles or across continental scarps for offshore field developments. Slug-flow-induced fatigue damage on the free spans can have a significant effect on project economics. Slug-flow assessments can prove time-consuming. The complete paper describes an integrated iterative approach between the flow-assurance and pipeline-engineering disciplines to streamline the work flow based on the value or cost associated with changes in input parameters that affect pipeline fatigue-assessment outcomes.

Slug-Flow Assessment Work Flow
The complete paper further details key goals for each step.
Step 1: Plan Project Slug-Flow Design Requirements. Key to this step is to create a close interface between flow-assurance and pipeline engineers to discuss and align overall timing, critical decisions, and hold points that are required as part of the slug-flow assessment and any specific project-design considerations.
Step 2: Execute Slug-Flow-Prediction Assessment. Slug-flow prediction typically is conducted by engineers using industry-standard multiphase dynamic-flow simulators. The step requires significant time and effort because of long simulation times and large data post-processing requirements.
Step 3: Generate Slug-Flow Interface Data. The two methods typically used for converting flow-assurance slug-flow results into formats that can be used readily by pipeline engineers are the time-history approach and the time-dependent-matrix approach.
Step 4: Execute Slug-Flow Response Assessment. This assessment typically is conducted by pipeline engineers to assess the effects of predicted slug-flow interface data on proposed pipeline con-figuration designs. Industry-standard finite-element-analysis (FEA) tools are used for this step.
Step 5: Finalize Design Through Iteration and Optimization. Where the slug-flow response assessment results show excessive fatigue damage that affects feasibility of the proposed design, iteration and optimization are performed.
Step 6: Consider Operational Monitoring Requirements. Operational fatigue monitoring can be considered if operational restrictions are required or if some level of risk or concern remains with the final design.
The Effect of Faults on the Behaviour of the Earth Dam – Case Study of the Ourkiss Dam
Authors: Beghzim Hassiba , Karech Toufik , Bouzid Tayeb 
Published: December 2021

Abstract
The analysis of the failure due to the effect of the propagation of normal and reversed faults with different angles of inclination and by sliding through the Ourkiss dam isstudied numerically. Mainly at the end of construction and at the highest water level, for this purpose the non-linear finite difference method is used considering four fault angles of inclination, activated at the center of the base of the embankment.The results of the study show that the shear stress values increase with the increase of the vertical base displacement imposed in both conditions of the dam state, and this for both normal and overturned faults.
Liver Histological Abnormalities Were Better Reflected by Virus Level in Chronic Hbv Infected Patients Aged ≤ 30 Years, Hbeag-Positive and Persistently Normal Alt
Authors: Wei Li , Liu Xiaoqing , Tang Qiao , Li Hu , Hu Peng 
Published: December 2021

Abstract
Background: We analyzed correlations between significant liver histological characteristics and clinical variables in HBV-infected patients and provided recommendations on treatment decisions for patients age younger than 30-year-old.Methods: Liver biopsy was performed on 161 chronic HBV-infected patients with ALT ≤ 40 U/L from July, 2000 – November, 2019. Median age was 39(18-70) years old. Histologic assessment was based on the Scheuer scoring system. Results: Significant necroinflammation and fibrosis were observed in 65.2% (105/161) and 52.2% (84/161) patients of all cases. The pathological abnormality was significantly negatively correlated with viral level in HBeAg-positive subjects, and based on ROC curve analysis, the viral level to predict obvious liver pathological changes was 6.7 log10 IU/ml in those patients. Threshold value of ALT (25 U/L) based on the distribution of ALT and virus levels. Patients younger than 30 years old, almost all had significant pathological alteration with HBV-DNA < 6.7 log10 IU/ml; However, the ratio of insignificant liver’s inflammation and fibrosis were 65% and 70% with HBV-DNA levels ≥ 6.7 log10 IU/ml respectively, on that basis, it could have a further rising, reaching 67.5% and 75% combining with ALT ≤ 25 U/L. Conclusion: Viral load was a better factor to reflect hepatic histological abnormality in Chronic HBV-infected patients with HBeAg-positive and persistently normal ALT whose age ≤ 30 years, 5000000 IU/ml was a suitable threshold.
Suicidal Ideation and Risk Reduction Associated with Participation in a Therapist-Supported Digital Mental Health Intervention
Authors: Nelson Benjamin W. , Hornstein Silvan , Viiala Vilma , Gillung Erin , Peiper Nicholas , Forman-Hoffman Valerie L. 
Published: December 2021

Abstract
Background
Suicide is a significant public health concern with increasing prevalence. Novel interventions that reduce stigma and increase accessibility, such as therapist-supported digital mental health interventions, are urgently needed.
Methods
This preregistered retrospective cohort, single-arm, and intent-to-treat study with 778 patients examined suicidal ideation (SI) trajectories using multilevel models during and up to 6-months after an 12-week therapist-supported digital mental health intervention (Meru Health Program [MHP]) as assessed by the ninth item of the Patient Health Questionnaire-9 (PHQ-9). Estimates of associated suicide attempts and deaths by suicide were calculated using published data linking PHQ-9-assessed SI to records of suicide attempts and deaths by suicide.
Results
MHP participants reporting SI “not at all” significantly increased between baseline and end-of-treatment (78.02–91.00%). Effect sizes of SI changes between baseline and end-of-treatment, 3-month, and 6-month follow-ups were 0.33 (95%CI=0.27-0.38), 0.32 (95%CI=0.27-0.38), and 0.32 (95%CI=0.27-0.438), respectively. Results also indicated an estimated 30.49% reduction (95%CI=25.15%-35.13%) in suicide attempts and death by suicide across treatment.
Conclusion
This real-world study provides preliminary evidence that participants of the MHP show significant reductions in SI and estimated suicide attempts and deaths by suicide across treatment that are maintained 6-months following treatment. The next steps are to conduct a randomized control trial to confirm these results.
Diagnostic Dilemmas: A Multi-Institutional Retrospective Analysis of Adrenal Incidentaloma Pathology Based on Radiographic Size
Authors: Zekan David , King Robert Scott , Hajiran Ali , Patel Apexa , Deem Samuel , Luchey Adam 
Published: December 2021

Abstract
Introduction/Background

Adrenal incidentalomas (AIs) are masses >1 cm found incidentally during radiographic imaging. They are present in up to 4.4% of patients undergoing CT scan, and incidence is increasing with usage and sensitivity of cross-sectional imaging. Most result in diagnosis of adrenal cortical adenoma, questioning guidelines recommending removal of all AIs with negative functional workup. This retrospective study analyzes histological outcome based on size of non-functional adrenal masses.
Material and Methods

10 years of data was analyzed from two academic institutions. Exclusion criteria included patients with positive functional workups, those who underwent adrenalectomy during nephrectomy, <18 years, and incomplete records. AI radiologic and histologic size, histologic outcome, laterality, imaging modality, gender, and age were collected. T-test was used for comparison of continuous variables, and the two-sided Fisher’s exact or chi-square test were used to determine differences for categorical variables. Univariate analysis of each independent variable was performed using simple logistic regression.
Results

73 adrenalectomies met the above inclusion criteria. 60 were detected on CT scan, 12 on MRI, and one on ultrasound. Eight of 73 cases resulted in malignant pathology, 3 of which were adrenocortical carcinoma (ACC). Each ACC measured >6 cm, with mean radiologic and pathologic sizes of 11.2 cm and 11.3 cm. Both radiologic and pathologic size were significant predictors of malignancy (p=0.008 and 0.011).
Conclusions

Our results question the generally-accepted 4 cm cutoff for excision of metabolically-silent AIs. They suggest a 6 cm threshold would suffice to avoid removal of benign lesions while maintaining sensitivity for ACC.
Mobile-PolypNet : Light-weight Colon Polyp Segmentation Network for Low Resources Settings
Authors: Karmakar Ranit , Nooshabadi Saeid 
Published: December 2021

Abstract
Colon polyps, small clump of cells on the lining of the colon can lead to Colorectal cancer (CRC), one of the leading types of cancer globally. Hence, early detection of these polyps is crucial in the prevention of CRC. This paper proposes a lightweight deep learning model for colorectal polyp segmentation that achieved state-of-the-art accuracy while significantly reducing the model size and complexity. The proposed deep learning autoencoder model employs a set of state-of-the-art architectural blocks and optimization objective functions to achieve the desired efficiency. The model is trained and tested on five publicly available colorectal polyp segmentation datasets (CVC-ClinicDB, CVC-ColonDB, EndoScene, Kvasir, and ETIS). We also performed ablation testing on the model to test various aspects of the autoencoder architecture. We performed the model evaluation using most of the common image segmentation metrics. The backbone model achieved a dice score of 0.935 on the Kvasir dataset and 0.945 on the CVC-ClinicDB dataset improving the accuracy by 4.12% and 5.12% respectively over the current state-of-the-art network, while using 88 times fewer parameters, 40 times less storage space, and being computationally 17 times more efficient. Our ablation study showed that the addition of ConvSkip in the autoencoder slightly improves the model’s performance but it was not significant (p-value=0.815).
The Establishment of Transformer-Based Computer-Aided Diagnosis Model to Improve the Classification Consistency of BI-RADS-US3–5 Nodules Among Radiologists: A Multi-Center Study
Authors: Ji Hongtao , Zhu Qiang , Ma Teng , Cheng Yun , Zhou Shuai , Ren Wei , Huang Huilian , He Wen , Ran Haitao , Ruan Litao , Guo Yanli , Tian Jiawei , Chen Wu , Chen Luzeng , Wang Zhiyuan , Zhou Qi , Niu Lijuan , Zhang Wei , Yang Ruimin , Chen Qin , Zhang Ruifang , Wang Hui , Li Li , Liu Minghui , Nie Fang , Zhou Aiyun 
Published: December 2021

Abstract
Background: Significant differences exist in classification outcomes for radiologists using ultrasonography-based breast imaging-reporting and data systems for diagnosing category 3–5 (BI-RADS-US 3–5) breast nodules, due to a lack of clear and distinguishing image features. As such, this study investigates the use of a transformer-based computer-aided diagnosis (CAD) model for improved BI-RADS-US 3–5 classification consistency.Methods: Five radiologists independently performed BI-RADS-US annotations on a breast ultrasonography image set collected from 20 hospitals in China. The data were divided into training, validation, testing, and sampling sets. The trained transformer-based CAD model was then used to classify test images, for which sensitivity, specificity, and accuracy were calculated. Variations in these metrics among the 5 radiologists were analyzed by referencing BI-RADS-US classification results for the sampling test set, provided by CAD, to determine whether classification consistency (the kappa value)，sensitivity, specificity, and accuracy had improved.Results: Classification accuracy for the CAD model applied to the test set was 95.7% for category 3 nodules, 97.6% for category 4A nodules, 95.60% for category 4B nodules, 94.2% for category 4C nodules, and 97.5% for category 5 nodules. Adjustments were made to 1,583 nodules, as 905 were classified to a higher category and 678 to a lower category in the sampling test set. As a result, the accuracy, sensitivity, and specificity of classification by each radiologist improved, with the consistency (kappa values) for all radiologists increasing to >0.60.Conclusions: The proposed transformer-based CAD model improved BI-RADS-US 3–5 nodule classification by individual radiologists and increased diagnostic consistency.
Elevated IL-6 in Pre-Eclampsia Increases Neurite Growth and Mitochondrial Respiration in an in vitro Model of Neuronal Development
Authors: Barron Aaron , Manna Samprikta , McElwain Colm , Musumeci Andrea , McCarthy Fergus , O'Keeffe Gerard , McCarthy Cathal 
Published: December 2021

Abstract
Pre-eclampsia (PE) is a common and serious hypertensive disorder of pregnancy, which affects 3-5% of first-time pregnancies and is a leading cause of maternal and neonatal morbidity and mortality. Prenatal exposure to PE is associated with an increased risk of neurodevelopmental disorders in affected offspring, although the cellular and molecular basis of this are largely unknown. In this study we examined the effects of exposure to maternal serum from women with PE or a healthy uncomplicated pregnancy on the survival, neurite growth and mitochondrial function of SH-SY5Y cells. We report that cells exposed to PE serum exhibited increased neurite growth and mitochondrial respiration, two important neurodevelopmental parameters, compared to those treated with control serum. Levels of the pleiotropic cytokine IL-6 were significantly elevated in the PE sera, and cells exposed to PE serum displayed increased phospho-STAT3 levels which is a key intracellular mediator of IL-6 signalling. Finally, we show that treating these cells with IL-6 alone is sufficient to induce a similar neurite growth and respiratory phenotype to PE serum-exposed cells. This suggests that elevated IL-6 seen in maternal serum in PE may be responsible at least in part for its inducing increased neurite growth and mitochondrial respiration in SH-SY5Y cells. Overall, this study demonstrates that there are circulating factors in the serum of women with pre-eclampsia that affect neuronal development and oxygen consumption differently to that of a healthy uncomplicated pregnancy, and that immune dysregulation via elevated IL-6 may be important in mediating these effects.
Peptoniphilus Colimassiliensis sp. nov. and Peptoniphilus Urinimassiliensis sp. nov., Two New Species Isolated From Humans
Authors: Mbaye Babacar , LO Cheikh Ibrahima , Dione Niokhor , Benabdelkader Sarah , Alou Maryam Tidjani , Brahimi Samy , Armstrong Nicholas , Alibar Stéphane , Raoult Didier , Moal Valérie , Million Matthieu , Fournier Pierre-Edouard , FENOLLAR Florence 
Published: December 2021

Abstract
Strains Marseille-P3761 and Marseille-P3195 are representatives of two bacterial species isolated from human specimens. Strain Marseille-P3761 was isolated from the stool of a healthy volunteer, while strain Marseille-P3915 was cultivated from the urine of a kidney transplant recipient. Both strains are anaerobic Gram-positive cocci bacteria. Both are catalase-negative and oxidase-negative and grow optimally at 37°C in anaerobic conditions. They also metabolize carbohydrates such as galactose, glucose, fructose, and glycerol. The major fatty acids were hexadecanoic acid for both strains, Marseille-P3761 (38%) and Marseille-P3195 (31%). The highest DNA-DNA hybridization values of Marseille-P3761 and Marseille-P3195 strains when compared to their closest phylogenetic relatives were 52.3% and 56.4%, respectively. The morphological, biochemical, phenotypic and genomic characteristics strongly support that these strains are new members of the Peptoniphilus genus. Thus, we suggest that strains Marseille-P3761 (CSUR P3761 = CCUG71569) and Marseille-P3195 (CSUR P3195 = DSM 103468) are the type strains of two new Peptoniphilus species, for which we propose the names Peptoniphilus colimassiliensis sp. nov. and Peptoniphilus urinimassiliensis sp. nov., respectively.
Metabolomic Analysis of Skin Malodor-Associated Compounds and Structure-based Prediction of Acetolactate Synthase Selective Sulfonylurea Inhibitors
Authors: Huang Ryan Yuki 
Published: December 2021

Abstract
Bromhidrosis is characterized as a chronic condition related to malodor from the skin. The underlying etiology is from bacterial decompositions of glandular secretion products. However, specific pathways and metabolites for the disease are yet to be investigated. Here, twenty-eight metabolites, including fifteen major sweat constituents and thirteen compounds emitted from malodor-producing skin bacteria, were subjected to the metabometric analysis using Metaboanalyst. Different pathways in the butanoate metabolism revealed that acetolactate synthase (ALS) in skin Staphylococcus epidermidis (S. epidermidis) bacteria are catalyzing pyruvate to several malodor compounds like diacetyl. In the docking studies of the sulfonylurea-ALS interaction, five selected sulfonylureas, which originally were developed for the treatment of diabetes mellitus type 2, showed different binding free energies (ΔG) from chlorimuron ethyl - a well-known ALS sulfonylurea inhibitor. Amongst five sulfonylureas, gliquidone and glisoxepide were found to have free energy differences that were lower than or equal to chlorimuron ethyl, revealing their high affinities to ALS. In the future, further investigations of gliquidone and glisoxepide against ALS in skin bacteria would be crucial in repurposing these two sulfonylureas as new anti-bromhidrosis drugs.
Dual mode of action of Talaromyces purpureogenus CFRM02 pigment to ameliorate alcohol induced liver toxicity in rats
Authors: Pandit Saritha Gopal , Mekala Krishna Prashanth Ramesh , Puttananjaiah Mohankumari H. , Peddha Muthukumar Serva , Dhale Mohan A 
Published: December 2021

Abstract
Talaromyces purpureogenus CFRM02 pigment exhibited antioxidant activity by scavenging free radicals. The alcohol feeding lead to free radical generation causing pathophysiological processes of alcoholic liver disease (ALD) and alcoholic hepatitis. The T. purpureogenus CFRM02 pigment administered to rats ameliorated the ALD by scavenging ROS. The haematological analysis revealed the increased neutrophil circulation. The neutrophil infiltration was observed in the hepatocytes of the rats fed with pigment (600 mg/kg body weight). The increase in number of neutrophils help in the liver regeneration caused by alcoholic hepatitis. The dual mechanism of action of pigment, antioxidant and liver regeneration through neutrophil production is attributed to alleviate the ALD. These results suggested T. purpureogenus CFRM02 pigment represents a novel protective and therapeutic strategy against ALD.
Specimen Mammography for Intraoperative Margin Assessment in Breast Conserving Surgery: A Meta-Analysis
Authors: Lin Chen , Wang Kai-yue , Chen Hailang , Xu Yuhua , Pan Tao , Chen Yiding 
Published: December 2021

Abstract
Specimen mammography is one of the widely used intraoperative methods assessing margin status in breast conserving surgery. We performed a meta-analysis to evaluate the diagnostic accuracy of specimen mammography. Literature databases including Pubmed, Cochrane Library, Web of Science and EMBASE were searched prior to May 2020. 18 studies with a total of 1142 patients were included. Data was extracted to perform pooled analysis, heterogeneity testing, threshold effect testing, sensitivity analysis, publication bias analysis and subgroup analyses. The pooled weighted values were a sensitivity of 0.55 (95% CI, 0.45–0.64), a specificity of 0.85 (95% CI, 0.77–0.90), a DOR of 7 (95% CI, 4–11) and a pooled positive likelihood ratio of 3.6 (95% CI 2.4-5.3). The area under the receiver operator characteristic curve was 0.75 (95% CI 0.71-0.78). In the subgroup analysis, the pooled specificity in the positive margin defined as tumor at margin subgroup was lower than the other positive margin definition subgroup (0.79 [95% CI: 0.66, 0.91] vs. 0.88 [95% CI: 0.81, 0.95], p = 0.01). Our findings indicated specimen mammography to be an accurate and intraoperative imaging technique for margin assessment in breast conserving surgery.
Could Small Neurotoxins-Peptides be Expressed during SARS-CoV-2 Infection?
Authors: Cafiero Concetta , Micera Alessandra , Re Agnese , Postiglione Loredana , Cacciamani Andrea , Schiavone Beniamino , Benincasa Giulio , Palmirotta Raffaele 
Published: December 2021

:
SARS-CoV-2 pathogenesis has been recently extended to human central nervous system (CNS), in addition to nasopharyngeal truck, eye, lung and gut. The recent literature highlights that some SARS-CoV-2 spike glycoprotein regions homologous to neurotoxin-like peptides might bind to human nicotinic Acetyl-Choline Receptors (nAChRs). Spike-nAChR interaction can probably cause dysregulation of CNS and cholinergic anti-inflammatory pathways and uncontrolled immune-response, both associated to a severe COVID-19 pathophysiology. Herein, we hypothesize that inside the Open Reading Frame (ORF) region of spike glycoprotein, the RNA polymerase can translate small neurotoxic peptides by means of a “jumping mechanism” already demonstrated in other coronaviruses. These small peptides can bind the snAChRs instead of Spike glycoproteins. A striking homology occurred between these small peptides observed by sequence retrieval and proteins alignment. Acting as nAChRs antagonists, these small peptides (conotoxins) could be the explanation for the extrapulmonary clinical manifestations (neurological, hemorrhagic and thrombotic expressions, the prolonged apnea, the cardiocirculatory collapse, the heart arrhythmias, the ventricular tachycardia, the body temperature alteration, the electrolyte K+ imbalance and finally the significant reduction of butyryl cholinesterase (BuChE) plasma levels, as observed in COVID-19 patients. Several factors might induce the expression of these small peptides, including microbiota. The main hypothesis regarding the presence of these small peptides opens a new scenario on the etiology of COVID-19 clinical symptoms observed so far, including the neurological manifestations.
An Overview of Combination Treatment with Citicoline in Dementia
Authors: Gareri Pietro , Veronese Nicola , Cotroneo Antonino Maria 
Published: December 2021

Introduction:
The present article reports an overview of the studies about combination
treatment with citicoline of Alzheimer’s (AD) and mixed dementia (MD).

Methods:
A Medline search was carried out by using the keywords Alzheimer’s dementia, mixed
dementia, older people, treatment with citicoline, memantine, and acetylcholinesterase inhibitors
(AchEIs).

Results:
Six studies were found to match the combination treatment of citicoline with AcheIs
and/or memantine. The CITIRIVAD and CITICHOLINAGE studies were the first to report the potential
benefits of adding citicoline to acetylcholinesterase inhibitors (AchEIs). Then, we added citicoline
to memantine in the CITIMEM study, and finally, we demonstrated benefits in terms of delay
in cognitive worsening with the triple therapy (citicoline + AchEIs + memantine). Other authors
also reinforced our hypothesis through two further studies.

Conclusions:
Open, prospective studies are advised to confirm the utility of combination therapy
with citicoline for the treatment of AD and MD.