bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cabergoline Stimulates Human Endometrial Stromal Cell Decidualization and Reverses Effects of Interleukin-1β In Vitro
Authors: Yu Jie , Berga Sarah L , Meng Qingying , Xia Mingjing , Kohout Trudy A , van Duin Marcel , Taylor Robert N 
Published: July 2021

Abstract

Context
Human embryonic implantation is regulated by neuroendocrine hormones, ovarian steroids, growth factors, and cytokines. Sympathetic innervation of the uterus also may play a role.

Objective
We tested the hypothesis that cabergoline (Cb), an agonist of type 2 dopamine receptors (DRD2), could influence endometrial decidualization in vitro.

Methods
Immunohistochemistry confirmed the presence of catecholaminergic neurons in human uterine tissue. DRD2 mRNA and protein expression in endometrial tissue and cells were validated by quantitative RT-PCR, cDNA microarrays, RNA sequencing, and Western blotting. Isolated human endometrial stromal cells (ESC) were subjected to dose-response and time-course experiments in the absence or presence of decidualizing hormones (10 nM estradiol, 100 nM progesterone, and 0.5 mM dibutyryl cAMP). In some cases, interleukin (IL)-1β (0.1 nM) was used as an inflammatory stimulus. Well-characterized in vitro biomarkers were quantified.

Results
DRD2 were maximally expressed in vivo in the mid-secretory phase of the cycle and upregulated in ESC in response to decidualizing hormones, as were classical (eg, prolactin) and emerging (eg, VEGF and connexin 43) differentiation biomarkers. Cabergoline treatment more than doubled decidual biomarker expression, whereas risperidone, a dopamine receptor antagonist, inhibited ESC differentiation by &gt;50%. Cabergoline induced characteristic decidual morphology changes and blocked detrimental effects of IL-1β on decidual cytology.

Conclusion
Our results support the hypothesis that dopaminergic neurons modulate decidualization in situ. We postulate that dopamine agonists, like Cb, could be developed as therapeutic agents to enhance implantation in couples with inflammation-associated infertility.
Day-of-Surgery Gabapentinoids and Prolonged Opioid Use: A Retrospective Cohort Study of Medicare Patients Using Electronic Health Records
Authors: Young Jessica C. , Dasgupta Nabarun , Chidgey Brooke A. , Stürmer Til , Pate Virginia , Hudgens Michael , Jonsson Funk Michele 
Published: July 2021

BACKGROUND:
While preoperative gabapentinoids are commonly used in surgical multimodal analgesia protocols, little is known regarding the effects this therapy has on prolonged postsurgical opioid use. In this observational study, we used data from a large integrated health care system to estimate the association between preoperative day-of-surgery gabapentinoids and the risk of prolonged postsurgical opioid use.

METHODS:
We identified adults age ≥65 years undergoing major therapeutic surgical procedures from a large integrated health care system from 2016 to 2019. Exposure to preoperative gabapentinoids on the day of surgery was measured using inpatient medication administration records, and the outcome of prolonged opioid use was measured using outpatient medication orders. We used stabilized inverse probability of treatment-weighted log-binomial regression to estimate risk ratios and 95% confidence intervals (CIs) of prolonged opioid use, comparing patients who received preoperative gabapentinoids to those who did not and adjusting for relevant clinical factors. The main analysis was conducted in the overall surgical population, and a secondary analysis was conducted among procedures where at least 30% of all patients received a preoperative gabapentinoid.

RESULTS:
Overall, 13,958 surgical patients met inclusion criteria, of whom 21.0% received preoperative gabapentinoids. The observed 90-day risk of prolonged opioid use following surgery was 0.91% (95% CI, 0.77–1.08). Preoperative gabapentinoid administration was not associated with a reduced risk of prolonged opioid use in the main analysis conducted in a broad surgical population (adjusted risk ratio [adjRR], 1.19 [95% CI, 0.67–2.12]) or in the secondary analysis conducted in patients undergoing colorectal resection, hip arthroplasty, knee arthroplasty, or hysterectomy (adjRR, 1.01 [95% CI, 0.30–3.33]).

CONCLUSIONS:
In a large integrated health system, we did not find evidence that preoperative gabapentinoids were associated with reduced risk of prolonged opioid use in patients undergoing a broad range of surgeries.
The RNA-binding protein Puf5 contributes to buffering of mRNA upon chromatin-mediated changes in nascent transcription
Authors: Kochan David Z. , Mawer Julia S. P. , Massen Jennifer , Tishinov Kiril , Parekh Swati , Graef Martin , Spang Anne , Tessarz Peter 
Published: July 2021

ABSTRACT
Gene expression involves regulation of chromatin structure and transcription, as well as processing of the transcribed mRNA. While there are feedback mechanisms, it is not clear whether these include crosstalk between chromatin architecture and mRNA decay. To address this, we performed a genome-wide genetic screen using a Saccharomyces cerevisiae strain harbouring the H3K56A mutation, which is known to perturb chromatin structure and nascent transcription. We identified Puf5 (also known as Mpt5) as essential in an H3K56A background. Depletion of Puf5 in this background leads to downregulation of Puf5 targets. We suggest that Puf5 plays a role in post-transcriptional buffering of mRNAs, and support this by transcriptional shutoff experiments in which Puf5 mRNA targets are degraded slower in H3K56A cells compared to wild-type cells. Finally, we show that post-transcriptional buffering of Puf5 targets is widespread and does not occur only in an H3K56A mutant, but also in an H3K4R background, which leads to a global increase in nascent transcription. Our data suggest that Puf5 determines the fate of its mRNA targets in a context-dependent manner acting as an mRNA surveillance hub balancing deregulated nascent transcription to maintain physiological mRNA levels.
Olefination of Aldehydes with Ethyl Diazoacetate Catalyzed by Nitrogen-doped Carbon-supported Metal
Authors: Yasukawa Tomohiro , Kume Sanshiro , Yamashita Yasuhiro , Kobayashi Shū 
Published: July 2021

Abstract
Nitrogen-doped carbon-supported Co/Cu bimetallic catalysts were found to catalyze olefination of aldehydes with ethyl diazoacetate. In the presence of triaryl phosphine with electron-withdrawing groups, various aromatic aldehydes could be converted into unsaturated esters in good to high yields. The system is heterogeneous, allowing for recovery and reuse of the catalyst for several runs without significant loss of activity.
Chiral Vanadium(V)-catalyzed Oxidative Coupling of 4-Hydroxycarbazoles
Authors: Kamble Ganesh T , Salem Mohamed S H , Abe Tsukasa , Park Hanseok , Sako Makoto , Takizawa Shinobu , Sasai Hiroaki 
Published: July 2021

Abstract
Enantioselective oxidative couplings of 4-hydroxycarbazoles using a chiral dinuclear vanadium(V) complex have been achieved for the first time. Under the mild reaction conditions, the corresponding dimeric 4-hydroxycarbazoles were obtained in up to 90% ee.
Extension of the Linear Response Function of Electron Density to a Plane-wave Basis and the First Application to Periodic Surface Systems
Authors: Maruyama Tomohiro , Ohnari Jinta , Tada Kohei , Hinuma Yoyo , Kawakami Takashi , Yamanaka Shusuke , Okumura Mitsutaka 
Published: July 2021

Abstract
This paper proposed using the linear response function (LRF) of Kohn-Sham orbitals for checking the convergence regarding thickness in periodic slab-and-vacuum model calculations. The effectiveness was demonstrated using the alkaline earth metal oxide (001) surface. The calculated LRF decreases and converges to zero toward the opposite side of a slab. The proposed LRF scheme can be used as a guide to judge convergence of the slab thickness.
Who asked you? Young People and practitioners identify ways to facilitate access to mental health supports
Authors: Colleran Ann , O'Connor Anne , Hogan Michael J. , Harney Owen M. , Durand Hannah , Hanlon Michelle 
Published: July 2021

Background: Despite representing the highest level of total population mental health burden, young people are the least likely to seek help from mental health services. It has been suggested that service design can influence the likelihood that young people will look for help, but little is known about how young people would like a service to be designed. This study addresses a gap in research regarding how mental health services can be designed to facilitate access for young people. Methods: A collective intelligence, scenario-based design methodology was used to facilitate stakeholders to identify and prioritise ways to improve youth mental health services. In total, 74 15–17-year-olds from three geographically diverse schools in Ireland worked to identify barriers to help-seeking and to generate and prioritise options in response to barriers. Nine practitioners with experience of working in youth mental health services rated all options in terms of both potential impact on help-seeking and feasibility for service implementation. Results: A total of 326 barriers across 15 themes were generated by youth stakeholders, along with 133 options in response to barriers. Through a process of voting, young people identified 30 options as the most impactful for improving access to mental health services. Of these options, 12 were also rated by practitioners as having both high potential impact and high feasibility. These 12 options focused on four areas: making services more familiar and welcoming; providing specialist mental health input in schools; improving parental understanding; and improving the visibility of appropriate supports. Conclusions: The results of the current study inform mental health service innovation and development, in particular, by highlighting potentially impactful and feasible ways to adapt existing mental health services to improve young people’s help-seeking behaviour.
II Brygada Legionów Polskich w Karpatach (listopad-grudzień 1914 r.). Cz. II
Authors: Dudek Tomasz 
Published: July 2021

The Brigade II of the Polish Legions in the Carpathian Mountains (November‑December 1914): Part II
In this article, the author presents the activity of the Polish Legions, at that time commanded by the general Karol Durski, in the Carpathian Mountains. Polish soldiers had to fight there under very difficult conditions as a result of the numerous deficiencies in equipment and arms. Nonetheless, they tried to perform the tasks to which they were entrusted as best as they could. As opposed to the weakness of the Austro‑Hungarian army, the Polish units in this region played a decisive rule in halting the Russian offensive. This was a significant factor because if the Russians had crossed the Carpathians, this would have led to an invasion of Hungary, which could have had unpredictable consequences. In the first phase, the Polish units participated in the fight to liberate Máramaros County. The second phase comprised the armed conflict in the Nadvirna and Bohorodchany regions. This part of the skirmishes was finished with the bloody Battle of Mołotków on October 29, 1914. Although it ended with a tactical defeat of the Polish units, which were forced to retreat, it was, however, a tactical victory, as the Russians, exhausted by the daylong battle, were forced to cease their offensive manoeuvres.
Wojsko jako internowanie
Authors: Brodecka Elwira 
Published: July 2021

The Army as Internment: Forms of the Repression During the Martial Law in the Years 1982-1983 Against Activists of the Anticommunist Opposition Placed in Military Special Camps (Part I)
The work focuses its issues on one of the repression forms used in the martial law introduced on 13th December 1981 to pacify the society which tried to change the fossilised communist system through activity in the Independent Self-Governing Trade Union “Solidarity”. It was not a new solution in the Polish People’s Republic – just after the Second World War the communist authority drafted into “alternative military service” opponents of sovietisation of the country, directing them to forced labour in mines. Fearing a social rebellion before the second anniversary of the independent trade union registration, communist authorities interned in military special camps, functioning in Poland from 5 November 1982 to 3 February 1983, 1450 trade union activists and members of the political parties unaccepted by communists. 264 younger colleagues of these people were drafted into the basic military service lasting two years in three units intended for this purpose.
Fetal bovine acellular dermal matrix for the closure of diabetic foot ulcers: a prospective randomised controlled trial
Authors: Lantis John C , Snyder Robert , Reyzelman Alexander M , Van Gils Carl C , Sigal Felix , Vayser Dean , Caporusso Joseph M , Cazzell Shawn , Lavery Lawrence A ,   PriMatrix Study Group
Published: July 2021

Aim: The purpose of this clinical trial was to evaluate the safety and efficacy of a fetal bovine acellular dermal matrix (FBADM) plus standard of care (SOC) for treating hard-to-heal diabetic foot ulcers (DFUs). Method: A prospective, multi-centre, randomised controlled trial was carried out. The study included a 2-week run-in period, a 12-week treatment phase and a 4-week follow-up phase. The primary endpoint was complete wound closure at 12 weeks. Results: Twenty-one US sites enrolled and randomised 226 patients with hard-to-heal DFUs. The study was terminated early due to the COVID-19 pandemic, which led to a modified intent-to-treat (mITT) population of 207 patients, with 103 in the FBADM group and 104 in the SOC group. Of these participants, 161 completed the study per protocol (mPP population), with 79 receiving FBADM, and 82 without. At the first analysis point, patients treated with FBADM were found to be significantly more likely to achieve complete wound closure compared with SOC alone (mITT: 45.6% versus 27.9% p=0.008; mPP: 59.5% versus 35.6% p=0.002). The difference in outcome yielded an odds ratio of 2.2 (95% confidence interval (CI): 1.2, 3.9; p=0.008). Median time to closure within 12 weeks was 43 days for the FBADM group compared to 57 days for the SOC group (p=0.36). The median number of applications of FBADM to achieve closure was one. Adverse events were similar between groups and no product-related serious adverse events occurred. Conclusions: These results indicate that in many cases a single application of FBADM in conjunction with SOC offers a safe, faster and more effective treatment of DFUs than SOC alone.
Depolarization compensation with a spatially variable wave plate in a 116  W, 441  fs, 1  MHz Yb:YAG double-pass laser amplifier
Authors: Veselis Laurynas , Burokas Raimundas , Ulčinas Orestas , Gertus Titas , Michailovas Kirilas , Michailovas Andrejus 
Published: July 2021

A subpicosecond laser system featuring a fiber chirped pulse amplification-based seed laser and a double-pass end-pumped Yb:YAG crystal power amplifier was investigated. The key novelty of the system was the application of depolarization compensation using a specially designed spatially variable wave plate. To the best of our knowledge, this method was applied for the first time. The presented laser system produced pulses of 441 fs duration, 116 µJ pulse energy at 116 W average power with a beam quality of

M

2

∼

2.1

, featured optical-to-optical efficiency of 32% at room temperature (

T

=

20
∘

C

), and had residual depolarization level of 2.7%.
Heterodyne detection applied to a fiber Bragg grating-based sensor using a directly modulated distributed feedback laser
Authors: Kuroda Keiji 
Published: July 2021

The heterodyne detection technique is applied to a fiber Bragg grating (FBG)-based sensor. Specifically, a directly modulated distributed feedback laser array is used as a frequency scanning light source. Weak reflections from the FBG are recorded as a beat signal with a high signal-to-noise ratio using heterodyne detection. A reflection signal is clearly observed from the FBG with a reflectivity of 1% located at 60 km from the detection port.
Entangled sideband control scheme via frequency-comb-type seed beam
Authors: Tian Long , Shi Shaoping , Li Yuhang , Wu Yimiao , Li Wei , Wang Yajun , Liu Qiang , Zheng Yaohui 
Published: July 2021

We report a control scheme of entangled sideband modes without coherent amplitude by employing a frequency-comb-type seed beam. In this scheme, each tooth of the frequency comb serves as a control field for the corresponding downconversion mode. Consequently, all the degrees of freedom can be actively controlled, and the entanglement degrees are higher than 6.7 dB for two pairs of sidebands. We believe that this scheme provides a simple solution for the control of sideband modes, which could be further applied to achieve compact channel multiplexing quantum communications.
Long-term optical information storage in glass with ultraviolet-light-preprocessing-induced enhancement of the signal-to-noise ratio
Authors: Wang Zhuo , Zhang Bo , Tan Dezhi , Qiu Jianrong 
Published: July 2021

This Letter describes the realization of long-term optical information storage in glass using an enhanced signal-to-noise ratio (SNR). We show that the photo-oxidation of

E
u

2
+

ions in the glass matrix induced by ultraviolet light suppresses background signals, thereby enhancing by tenfold the SNR of

E
u

2
+

ions photoluminescence (PL) of the dots written by a femtosecond (fs) laser. Thus, smaller dots exhibiting weak PL emission can be detected. In addition, the stored information shows excellent stability under the light irradiation with the power density up to

240

W

/

c
m

2

. Accelerated-aging experiments indicate that the stored data can retain stability for more than 115 years at room temperature. The optical storage capacity is approximately

270

G
b
i
t

c
m

−
3

. This technique enables long-term, high-capacity data storage in glass media.
Comparison of sand fly trapping approaches for vector surveillance of Leishmania and Bartonella species in ecologically distinct, endemic regions of Peru
Authors: Zorrilla Victor O. , Lozano Marisa E. , Espada Liz J. , Kosoy Michael , McKee Clifton , Valdivia Hugo O. , Arevalo Heriberto , Troyes Mario , Stoops Craig A. , Fisher Michael L. , Vásquez Gissella M. 
Published: July 2021

BackgroundIn Peru, the information regarding sand fly vectors of leishmaniasis and bartonellosis in the Amazon region is limited. In this study, we carried out sand fly collections in Peruvian lowland and highland jungle areas using different trap type configurations and screened them forLeishmaniaandBartonellaDNA.Methodology/Principal findingsPhlebotomine sand flies were collected in Peruvian Amazon jungle and inter Andean regions using CDC light trap, UV and color LED traps, Mosquito Magnet trap, BG Sentinel trap, and a Shannon trap placed outside the houses.Leishmaniaspp. screening was performed by kDNA PCR and confirmed by a nested cytochrome B gene (cytB) PCR.Bartonellaspp. screening was performed by ITS PCR and confirmed by citrate synthase gene (gltA). The PCR amplicons were sequenced to identifyLeishmaniaandBartonellaspecies.UV and Blue LED traps collected the highest average number of sand flies per hour in low jungle; UV, Mosquito Magnet and Shannon traps in high jungle; and Mosquito Magnet in inter Andean region.Leishmania guyanensisinLutzomyia carrerai carreraiandL.naiffiinLu.hirsuta hirsutawere identified based oncytBsequencing.Bartonellaspp. related toBartonella bacilliformisinLu.whitmani,Lu.nevesi,Lu.hirsuta hirsutaandLu.sherlocki, and aBartonellasp. related toCandidatusB. rondoniensis inLu.nevesiandLu.maranonensiswere identified based ongltAgene sequencing.Conclusions/SignificanceUV, Blue LED, Mosquito Magnet and Shannon traps were more efficient than the BG-Sentinel, Green, and Red LED traps. This is the first report ofL.naiffiand of two genotypes ofBartonellaspp. related toB.bacilliformisandCandidatusB. rondoniensis infecting sand fly species from the Amazon region in Peru.
If you build it, will they come? Social, economic, and psychological determinants of COVID-19 testing decisions
Authors: Perry Brea L. , Aronson Brian , Railey Ashley F. , Ludema Christina 
Published: July 2021

Background
The efficacy of testing and tracing programs to reduce COVID-19 transmission hinges not only on widespread access to testing, but also on the public’s willingness to participate in them. To the extent that testing intentions are patterned by social determinants of health, this constitutes an understudied mechanism of disparities in COVID-19 morbidity and mortality.

Design
Using data from a representative household probability sample, the Person to Person Health Interview Study (n = 935), sociodemographic, economic, and psychological determinants of testing considerations were evaluated across six domains: treatment affordability, ability to work if positive, hospital effectiveness, symptom severity, proximity to infected, and risk of transmitting to others.

Results
Findings demonstrated significant differences in testing motivations across race/ethnicity, education level, socioeconomic status, and worry about self and loved ones. Notably, Black (p<0.01) and Latino (p<0.05) respondents and those experiencing financial strain (p<0.001) were disproportionately likely to indicate that resource factors would influence their decision to get tested. Desire to reduce transmission and concern about proximity to the infected were reported among those who expressed COVID-19 worries (p<0.001).

Conclusion
Public health efforts to combat the COVID-19 pandemic must address social, economic, and psychological factors that enable and constrain individual behavior. Increasing access to preventative interventions and technologies, including vaccines, is unlikely to markedly reduce morbidity and mortality without effective messaging and economic support to improve uptake in vulnerable populations.
Sero-surveillance for SARS-CoV-2 infection among healthcare providers in four hospitals in Thailand one year after the first community outbreak
Authors: Kittikraisak Wanitchaya , Piyaraj Phunlerd , Vachiraphan Apichat , Wongrapee Thanapat , Punjasamanvong Somsak , Hunsawong Taweewun , Sinthuwattanawibool Chalinthorn , Leepiyasakulchai Chaniya , Yoocharoen Pornsak , Azziz-Baumgartner Eduardo , Mott Joshua A. , Chottanapund Suthat 
Published: July 2021

BackgroundThailand was the first country outside China to report SARS-CoV-2 infected cases. Since the detection of the first imported case on January 12th, 2020 to the time this report was written, Thailand experienced two waves of community outbreaks (March-April 2020 and December 2020-March 2021). We examined prevalence of SARS-CoV-2 seropositivity among healthcare providers (HCPs) in four hospitals approximately one year after SARS-CoV-2 first detected in Thailand. By March 2021, these hospitals have treated a total of 709 coronavirus disease 2019 (COVID-19) patients.MethodsBlood specimens, collected from COVID-19 unvaccinated HCPs during January-March 2021, were tested for the presence of SARS-CoV-2 immunoglobulin G (IgG) antibodies to nucleocapsid (IgG-nucleocapsid) and spike (IgG-spike) proteins using Euroimmune®enzyme-linked immunosorbent assays.ResultsOf 600 HCPs enrolled, 1 (0.2%) tested positive for the SARS-CoV-2 IgG-spike antibodies, but not the IgG-nucleocapsid.ConclusionThe presence of SARS-CoV-2 IgG antibodies was rare in this sample of HCPs, suggesting that this population remains susceptible to SARS-CoV-2 infection.