bluuebunny/crossref_metadata_2025_split huggingface dataset:
Azole‐resistant Aspergillus fumigatus is highly prevalent in the environment of Vietnam, with marked variability by land use type
Authors: Duong Tra‐My N. , Le Thanh‐Van , Tran Khanh‐Linh H. , Nguyen Phuong‐Tuyen , Nguyen Bich‐Phuong T. , Nguyen Thu‐Anh , Nguyen Huong‐Lan P. , Nguyen Bich‐Ngoc T. , Fisher Matthew C. , Rhodes Johanna , Marks Guy , Fox Greg J. , Chen Sharon C.‐A. , Walsh Michael G. , Barrs Vanessa R. , Talbot Jessica , Halliday Catriona L. , Sorrell Tania C. , Day Jeremy N. , Beardsley Justin 
Published: July 2021

SummaryAzole‐resistant environmental Aspergillus fumigatus presents a threat to public health but the extent of this threat in Southeast Asia is poorly described. We conducted environmental surveillance in the Mekong Delta region of Vietnam, collecting air and ground samples across key land‐use types, and determined antifungal susceptibilities of Aspergillus section Fumigati (ASF) isolates and azole concentrations in soils. Of 119 ASF isolates, 55% were resistant (or non‐wild type) to itraconazole, 65% to posaconazole and 50% to voriconazole. Azole resistance was more frequent in A. fumigatus sensu stricto isolates (95%) than other ASF species (32%). Resistant isolates and agricultural azole residues were overrepresented in samples from cultivated land. cyp51A gene sequence analysis showed 38/56 resistant A. fumigatus sensu stricto isolates carried known resistance mutations, with TR34/L98H most frequent (34/38).
Brazil: hate and intolerance in times of pandemic in a mixed‐race country
Authors: Gadotti Claudia Morelli , Valente Vera Lucia Colson 
Published: July 2021

AbstractThis paper intends to analyse the current political and social situation in Brazil and show how this context has influenced the management of the public health crisis generated by the COVID‐19 pandemic. To this end, the authors conducted an investigation into Brazil’s historical roots, which have not only engendered deep class differences but, also, social psychopathologies such as dissociation and perversion. Finally, this paper presents a symbolic analysis of social exclusion and how the mythical figure of Sophia can inspire a renewed movement of inclusion and tolerance.
Essential anxiety: COVID‐19 in analytic practice
Authors: Schellinski Kristina 
Published: July 2021

AbstractThis paper explores the impact of the COVID‐19 pandemic on my relationship with analysands and my inner world. I reflect on the role of the archetypal Self during times of existential anxiety that may lead to an experience of ‘essential anxiety’. This term refers to a meeting by a fearful ego with an inward recognition of the Self, when faced with threat. The efforts to curb the spread of the pandemic changed our ways of life, while the virus itself threatened our existence in debilitating or outright destructive ways. But what also came into view, in sessions of analysis and supervision, was the creative instinct, and a celebration of life. The soul‐to‐soul relationship, and the connection with images of the archetypal Self, made the experience of existential anxiety at times an essential experience that facilitated psychological growth. I discuss some advantages of on‐line Jungian analysis where, despite distance and partial view, the body still serves as container to hold important psychological material, conferring a sense of wholeness for analyst and analysand. The COVID‐19 crisis is terrible and terrifying but it also provides an opportunity for self‐regulation and individuation.
Intersections of personal vs. collective trauma during the COVID‐19 pandemic: the hijacking of the human imagination
Authors: Kalsched Donald 
Published: July 2021

AbstractThis paper explores how the deadly shadow of COVID‐19 passing over the Earth constitutes a collective trauma that frequently opens up or ‘triggers’ un‐remembered personal trauma, and it provides clinical examples of these intersections. The paper further explores how the human imagination, which we normally utilize to make meaning out of traumatic experience, can be hijacked by fear – leading to avoidance of suffering and to illusory formulations and alternative realities such as conspiracy theories. Alternatively, the imagination can be employed in more realistic and creative ways – leading through conscious suffering to healing and wholeness. Which path the imagination takes is shown to depend on the capacity of individuals to feel the full reality of the human condition in general and the exquisite vulnerability of our existence as fragile human beings at this moment in history. Ernest Becker’s analysis of our ‘denial of death’ and his urgency to embrace our common human vulnerability is explored in relation to Jung’s early tendency to deny the body. The author proposes that the more creative uses of the imagination, connected to a more humble and realistic apprehension of our common destiny, may be seen in the ‘Black Lives Matter’ movement that swept the world in the aftermath of the COVID‐19 outbreak.
Role of fragmented QRS and Shanghai score system in recurrence of ventricular fibrillation in patients with early repolarization syndrome
Authors: Yonezu Keisuke , Shinohara Tetsuji , Sato Hiroki , Hirota Kei , Kondo Hidekazu , Fukui Akira , Teshima Yasushi , Yufu Kunio , Nakagawa Mikiko , Takahashi Naohiko 
Published: July 2021

AbstractBackgroundThe Shanghai Score System, which weighs electrocardiogram (ECG) findings reflecting repolarization abnormalities, has been proposed for diagnosis of early repolarization syndrome (ERS). However, recent studies have suggested the involvement of depolarization abnormalities in some ERS patients. The aim of this study was to validate the Shanghai Score System in predicting the recurrence of ventricular fibrillation (VF) in ERS patients. The predictive value of fragmented QRS (fQRS) was also investigated.MethodsFifteen consecutive ERS patients (14 males, median age of 47 years) with a history of VF were retrospectively reviewed. The Shanghai Score System points were calculated, and the presence of fQRS was evaluated.ResultsDuring the median follow‐up period of 79.2 months, five patients experienced VF recurrence. In the VF recurrence group, two patients showed augmented amplitude of J waves with horizontal ST‐segment, while the other three patients had dynamic changes in J‐wave amplitude. The Shanghai Score System points in the VF recurrence group were higher than those in the VF non‐recurrence group (6.5 [range: 5.8–6.8] vs. 4.5 [range: 4.0–4.5], p = 0.002). The presence of fQRS on standard 12‐lead ECG was more frequently observed in the VF recurrence group compared with the non‐recurrence group (100% vs. 10%, p = 0.002).ConclusionsThe present study demonstrated that the Shanghai Score System could effectively identify ERS patients at high risk for VF recurrence. The results also suggested that the presence of fQRS, a marker of depolarization abnormalities, may be useful for predicting VF recurrence in ERS patients.
Neurodevelopmental and psychiatric comorbidities negatively affect outcome in children with unprovoked seizures—A non‐systematic review
Authors: Åndell Jason Eva 
Published: July 2021

AbstractChildren with epilepsy have at least one comorbidity in 80% of cases. This unstructured review provides insights into the most common comorbidities, their effects on seizure prognosis and treatment. We also review the epilepsy terminology and classifications. Neurodevelopmental and psychiatric comorbidities were common in children with seizures and had a negative effect on quality of life, and seizure freedom. Children with seizures were treated with drugs used for attention deficit hyperactivity disorder (ADHD), depression or psychosis, more often than the general population but less often than prevalence rates would suggested.ConclusionMultidisciplinary teams should assess comorbidities in children with epilepsy to improve their care and outcomes.
Design, synthesis, and primary activity assays of baicalein derivatives as cyclin‐dependent kinase 1 inhibitors
Authors: Mou Jiajia , Qiu Shuang , Chen Danghui , Deng Yanru , Tekleab Teka 
Published: July 2021

AbstractMalignant tumor is a disease with high mortality. Traditional treatment methods have many disadvantages, such as side‐effects, drug resistance. Because cyclin‐dependent kinase 1 (CDK1) plays an indispensable role in cell cycle regulation, it became an attractive target in rational anti‐cancer drug discovery. Herein, we reported a series of baicalein derivatives, which remarkably repressed the proliferation of MCF‐7 tumor cells and the activity of CDK1/cyclin B kinase. Among them, compound 4a displayed better inhibition rate than flavopiridol against MCF‐7 proliferation at the concentration of 50 μg/ml, comparable to compound CGP74514A, while compound 3o possessed the best activity against CDK1/cyclin B kinase (IC50 = 1.26 μM). The inhibitory activities toward the kinase well correlated with anti‐proliferative activities. Molecular docking results suggested that compound 3o can interact with the key amino acid residues, E81, L83, and D146, of CDK1 through hydrogen bond just like flavopiridol does. And it can also form an extra hydrogen bond with D146 by its introduced 7‐acrylate group, which flavopiridol does not have. These findings proved that baicalein derivatives can be used as CDK1 inhibitors fighting against cancer.
Antiaggregant effects of (1,2,5‐oxadiazolyl)azasydnone ring assemblies as novel antiplatelet agents
Authors: Zhilin Egor S. , Ustyuzhanina Nadezhda E. , Fershtat Leonid L. , Nifantiev Nikolay E. , Makhova Nina N. 
Published: July 2021

AbstractA series of biheterocyclic assemblies comprising of 1,2,5‐oxadiazole and azasydnone scaffolds were synthesized and biologically evaluated as novel nitric oxide (NO)‐donor and antiplatelet agents. Depending on functional substituents at the biheterocyclic core, all studied compounds demonstrated good NO‐donor profiles releasing NO in a wide range of concentrations (19.2%–195.1%) according to a Griess assay. (1,2,5‐Oxadiazolyl)azasydnones showed excellent antiplatelet activity in the case of ADP and adrenaline used as inducers completely suppressing the aggregate formation even at the lowest test concentration of 0.0375 μmol/ml, which is a rather unique feature. Moreover, studied biheterocycles possess a selective mechanism of inhibition of platelet aggregation mediated only by ADP and adrenaline, which are considered to be the main inducers causing thrombus formation. In addition, (1,2,5‐oxadiazolyl)azasydnones were found to be completely non‐toxic to hybrid endothelial cells EaHy 926. Studies of hydrolytic degradation of the synthesized compounds afforded benzoic acid as a sole detectable decomposition product, which is considered advantageous in drug design. Therefore, (1,2,5‐oxadiazolyl)azasydnones represent a novel class of promising drug candidates with improved antiplatelet profile and reduced toxicity enabling their huge potential in medicinal chemistry and drug design.
Deciphering the detailed structure–activity relationship of coumarins as Monoamine oxidase enzyme inhibitors—An updated review
Authors: Koyiparambath Vishal Payyalot , Prayaga Rajappan Krishnendu , Rangarajan T. M. , Al‐Sehemi Abdullah G. , Pannipara Mehboobali , Bhaskar Vaishnav , Nair Aathira Sujathan , Sudevan Sachithra Thazhathuveedu , Kumar Sunil , Mathew Bijo 
Published: July 2021

AbstractIn the last few years, Monoamine oxidase (MAO) have emerged as a target for the treatment of many neurodegenerative diseases including anxiety, depression, Alzheimer's, and Parkinson's diseases. The MAO inhibitors especially selective and reversible inhibitors of either of the isoenzymes (MAO‐A & MAO‐B) have been given more attention as both the form have different therapeutic properties and hence can be used for different neurological disorders. The lack of selective and reversible inhibitors available for both the enzymes and severity of the neuronal disorder in society have opened a new door to the researchers to carry out large and dedicated researches in this field. Among the several classes of the molecule as the inhibitors, coumarins hold a rank as a potent scaffold with its ease of synthesis, high therapeutic potential, and reversibility in inhibiting MAOs. The current review is an update of the research in the field that covers the works during the last six years (2014–2020) with a major focus on the SAR of the coumarin derivatives including synthetic, natural, and hybrids of coumarins with FDA‐approved drugs.
Identifying key priorities for research to protect the consumer with food hypersensitivity: A UK Food Standards Agency Priority Setting Exercise
Authors: Turner Paul J. , Andoh‐Kesson Elizabeth , Baker Sarah , Baracaia Alexa , Barfield Alisha , Barnett Julie , Brunas Karen , Chan Chun‐Han , Cochrane Stella , Cowan Katherine , Feeney Mary , Flanagan Simon , Fox Adam T. , George Leigh , Gowland M. Hazel , Heeley Christina , Kimber Ian , Knibb Rebecca , Langford Kirsty , Mackie Alan , McLachlan Tim , Regent Lynne , Ridd Matthew , Roberts Graham , Rogers Adrian , Scadding Guy , Stoneham Sarah , Thomson Darryl , Urwin Heidi , Venter Carina , Walker Michael , Ward Rachel , Yarham Ross A. R. , Young Maggie , O’Brien John 
Published: July 2021

AbstractIntroductionFood hypersensitivity (FHS), including food allergy, coeliac disease and food intolerance, is a major public health issue. The Food Standards Agency (FSA), an independent UK Government department working to protect public health and consumers’ wider interests in food, sought to identify research priorities in the area of FHS.MethodsA priority setting exercise was undertaken, using a methodology adapted from the James Lind Alliance—the first such exercise with respect to food hypersensitivity. A UK‐wide public consultation was held to identify unanswered research questions. After excluding diagnostics, desensitization treatment and other questions which were out of scope for FSA or where FSA was already commissioning research, 15 indicative questions were identified and prioritized by a range of stakeholders, representing food businesses, patient groups, health care and academia, local authorities and the FSA.Results295 responses were received during the public consultation, which were categorized into 70 sub‐questions and used to define 15 key evidence uncertainties (‘indicative questions’) for prioritization. Using the JLA prioritization framework, this resulted in 10 priority uncertainties in evidence, from which 16 research questions were developed. These could be summarized under the following 5 themes: communication of allergens both within the food supply chain and then to the end consumer (ensuring trust in allergen communication); the impact of socio‐economic factors on consumers with FHS; drivers of severe reactions; mechanism(s) underlying loss of tolerance in FHS; and the risks posed by novel allergens/processing.DiscussionIn this first research prioritization exercise for food allergy and FHS, key priorities identified to protect the food‐allergic public were strategies to help allergic consumers to make confident food choices, prevention of FHS and increasing understanding of socio‐economic impacts. Diagnosis and treatment of FHS was not considered in this prioritization.
Ergonomic port placement in robotic colorectal surgery
Authors: Wong Shing Wai , Ang Zhen Hao , Chua Jia Lin , Crowe Philip 
Published: July 2021

AbstractAimThe aim of the study was to determine how spacing between ports and alignment of ports (oblique or vertical) influences manipulation angles in robotic colorectal surgery.MethodAbdominal CT scans of 10 consecutive robotic right hemicolectomy and 10 consecutive robotic high anterior resection patients were analysed. The manipulation angles were calculated using fixed points on the preoperative abdominal coronal CT scan. Port placements were marked on the CT scan. The fixed points used to measure the manipulation angles were from the most lateral part of the caecum, hepatic flexure, splenic flexure, the descending colon/sigmoid colon junction and the sigmoid colon/rectum junction.ResultsFor right hemicolectomy and high anterior resection surgery, a port spacing of 8 cm compared with 6 cm resulted in greater manipulation angles. With 6‐cm port spacing, wider manipulation angles were not achieved with vertical port alignment compared with oblique alignment except for dissection at the splenic flexure.ConclusionsThe greatest manipulation angles were achieved with the oblique 8‐cm port spacing, which should be used in most cases.
CEO tenure: An integrative review and pathways for future research
Authors: Darouichi Aïda , Kunisch Sven , Menz Markus , Cannella Albert A. 
Published: July 2021

AbstractResearch Question/IssueChief executive officer (CEO) tenure—the time a person spends in the CEO position—is a key observable characteristic of the CEO that has attracted considerable attention in the fields of management and accounting/finance. Yet, the research has evolved in parallel streams, and scholars have used CEO tenure as a proxy for various aspects of CEO givens and behaviors. The purpose of this paper is to consolidate, assess, and integrate the extant knowledge about CEO tenure from the fields of management and accounting/finance and, on that basis, stimulate future research.Research Findings/InsightsOur review reveals five key themes in CEO tenure research that have been studied across the management and accounting/finance fields: (1) CEO tenure and motivations; (2) CEO tenure and power; (3) CEO tenure and social capital; (4) CEO tenure and human capital; and (5) CEO tenure and stakeholder perceptions. We review the extant research along these research themes, highlighting the collective insights, contributions, and shortcomings within and between these themes.Theoretical/Academic ImplicationsOur review suggests that CEO tenure is a multifaceted, complex construct. To advance extant knowledge, we propose three pathways for future research: (1) substantiating knowledge within themes; (2) expanding knowledge across themes; and (3) advancing knowledge about temporal dynamics. We hope that research along those lines will help foster a richer and deeper understanding of the dynamic and complex nature of CEO tenure, which will also advance our understanding about CEOs in general.Practitioner/Policy ImplicationsOur study offers a comprehensive understanding of the nature of CEO tenure and its implications. Such an understanding can be leveraged to define appropriate policies and governance decisions that account for the dynamic nature of the CEO position.
Omega‐3 fatty acids in adipose tissue and risk of atrial fibrillation
Authors: Rix Thomas Andersen , Dinesen Pia , Lundbye‐Christensen Søren , Joensen Albert Marni , Riahi Sam , Overvad Kim , Schmidt Erik Berg 
Published: July 2021

AbstractBackgroundThe aim of the present study was to examine the relation between adipose tissue content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and the risk of incident atrial fibrillation (AF).MethodsIn this case‐cohort study based on data from the Danish Diet, Cancer and Health cohort, a total of 5255 incident cases of AF was identified during 16.9 years of follow‐up. Adipose tissue biopsies collected at baseline from all cases and from a randomly drawn subcohort of 3440 participants were determined by gas chromatography. Data were analysed using weighted Cox regression.ResultsData were available for 4741 incident cases of AF (2920 men and 1821 women). Participants in the highest vs. the lowest quintile of EPA experienced a 45% lower risk of AF (men HR 0.55 (95% CI 0.41–0.69); women HR 0.55 (0.41–0.72)). For DHA, no clear association was found in men, whereas in women, participants in the highest quintile of DHA in adipose tissue had a 30% lower risk of incident AF (HR 0.70 (0.54–0.91)) compared to participants in the lowest quintile.ConclusionsA monotonous inverse association was found for the content of EPA in adipose tissue and risk of AF in both men and women. The content of DHA was inversely associated with the risk of AF in women, whereas no clear association was found for men.
New insights into thermomechanical fatigue behavior of AISI Type 316 LN SS weld joint
Authors: Telagathoti Suresh Kumar , Atikukke Nagesha , Ramamurthy Kannan 
Published: July 2021

AbstractCyclic deformation and fracture behavior of a type 316 LN austenitic stainless steel (SS) weld joint (WJ) were investigated under thermomechanical fatigue (TMF) and isothermal low cycle fatigue (IF) cycling at the maximum temperature (Tmax) of TMF. A higher cyclic stress response (CSR) and reduced cyclic softening were observed under TMF compared with IF tests. In‐phase (IP) TMF resulted in lower lives compared with IF cycling at the Tmax and out‐of‐phase (OP) TMF, which was attributed to the more pronounced creep‐induced intergranular damage. Characterization of microstructural features and microhardness variations revealed that the accumulation of damage and associated failure depends on the strength and microstructural gradient, together with the deformation incompatibility. The crack propagation is found to depend on the individual and synergistic interactions of the microstructural transformations, creep, and oxidation, depending on the type of fatigue cycle (IF and IP/OP TMF), strain amplitude, and thermal cycling effects.
The SWIM study: Ethnic minority women's ideas and preferences for a tailored intervention to promote national cancer screening programmes—A qualitative interview study
Authors: Tatari Camilla Rahr , Andersen Berit , Brogaard Trine , Badre‐Esfahani Sara , Jaafar Negin , Kirkegaard Pia 
Published: July 2021

AbstractBackgroundEthnic minority women from non‐Western countries are less likely than the native women to participate in screening programmes for cervical cancer, breast cancer and colorectal cancer. This social inequality can result in loss of possibility for prevention, delayed diagnosis and treatment and, ultimately, lower chance of survival. Developing a tailored intervention might be the solution to reduce social inequalities in cancer screening, and a key feature in intervention research is to consult the target group.ObjectiveTo explore ethnic minority women's own ideas and preferences for a cancer screening intervention and identify their attitudes to different strategies.MethodsAn interview study with five focus group interviews, two group interviews with an interpreter and three individual interviews. Thirty‐seven women from 10 non‐Western countries contributed to the study. The interviews were audio‐recorded and transcribed verbatim followed by a thematic analysis.ResultsAccording to the women, a tailored intervention should focus on knowledge in the form of face‐to‐face teaching. The women further suggested information material in their own language with a simple, positive and concrete communication strategy. They would like to be involved in an awareness strategy and share the knowledge with their network.ConclusionEthnic minority women were interested in a tailored intervention, and they were keen to contribute with ideas and preferences. The findings emphasized the potential of a tailored intervention with specific suggestions to the content when attempting to reduce inequality in cancer screening participation.Patient or Public ContributionMinority women were involved in the interview study.