bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thyroxine Induces Acute Relaxation of Rat Skeletal Muscle Arteries via Integrin αvβ3, ERK1/2 and Integrin-Linked Kinase
Authors: Selivanova Ekaterina K. , Gaynullina Dina K. , Tarasova Olga S. 
Published: September 2021

Aim: Hyperthyroidism is associated with a decreased peripheral vascular resistance, which could be caused by the vasodilator genomic or non-genomic effects of thyroid hormones (TH). Non-genomic, or acute, effects develop within several minutes and involve a wide tissue-specific spectrum of molecular pathways poorly studied in vasculature. We aimed to investigate the mechanisms of acute effects of TH on rat skeletal muscle arteries.Methods: Sural arteries from male Wistar rats were used for isometric force recording (wire myography) and phosphorylated protein content measurement (Western blotting).Results: Both triiodothyronine (T3) and thyroxine (T4) reduced contractile response of sural arteries to α1-adrenoceptor agonist methoxamine. The effect of T4 was more prominent than T3 and not affected by iopanoic acid, an inhibitor of deiodinase 2. Endothelium denudation abolished the effect of T3, but not T4. Integrin αvβ3 inhibitor tetrac abolished the effect of T4 in endothelium-denuded arteries. T4 weakened methoxamine-induced elevation of phospho-MLC2 (Ser19) content in arterial samples. The effect of T4 in endothelium-denuded arteries was abolished by inhibiting ERK1/2 activation with U0126 as well as by ILK inhibitor Cpd22 but persisted in the presence of Src- or Rho-kinase inhibitors (PP2 and Y27632, respectively).Conclusion: Acute non-genomic relaxation of sural arteries induced by T3 is endothelium-dependent and that induced by T4 is endothelium-independent. The effect of T4 on α1-adrenergic contraction is stronger compared to T3 and involves the suppression of extracellular matrix signaling via integrin αvβ3, ERK1/2 and ILK with subsequent decrease of MLC2 (Ser19) phosphorylation.
Electrical Impedance Myography in Health and Physical Exercise: A Systematic Review and Future Perspectives
Authors: Cebrián-Ponce Álex , Irurtia Alfredo , Carrasco-Marginet Marta , Saco-Ledo Gonzalo , Girabent-Farrés Montserrat , Castizo-Olier Jorge 
Published: September 2021

Background: Electrical impedance myography (EIM) is a non-invasive method that provides information about muscle health and changes that occur within it. EIM is based on the analysis of three impedance variables: resistance, reactance, and the phase angle. This systematic review of the literature provides a deeper insight into the scope and range of applications of EIM in health and physical exercise. The main goal of this work was to systematically review the studies on the applications of EIM in health and physical exercise in order to summarize the current knowledge on this method and outline future perspectives in this growing area, including a proposal for a research agenda. Furthermore, some basic assessment principles are provided.Methods: Systematic literature searches on PubMed, Scopus, SPORTDiscus and Web of Science up to September 2020 were conducted on any empirical investigations using localized bioimpedance devices to perform EIM within health and physical exercise contexts. The search included healthy individuals, elite soccer players with skeletal muscle injury, and subjects with primary sarcopenia. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist was used to develop the systematic review protocol. The quality and risk of bias of the studies included were assessed with the AQUA tool.Results: Nineteen eligible original articles were included in this review, which were separated into three tables according to the nature of the study. The first table includes six studies on the bioelectrical characterization of muscle. The second table includes five studies analyzing muscle changes in injured elite soccer players. The third table includes studies on the short-, medium-, and long-term bioelectrical adaptations to physical exercise.Conclusions: EIM has been used for the evaluation of the muscle condition in the clinical field over the last few years, especially in different neuromuscular diseases. It can also play an important role in other contexts as an alternative to complex and expensive methods such as magnetic resonance imaging. However, further research is needed. The main step in establishing EIM as a valid tool in the scientific field is to standardize the protocol for performing impedance assessments.
Prevalence and Risk Factors of Home Quarantine Strategy Implementation Among Chinese Residents During the Coronavirus Disease 2019 Pandemic
Authors: Li Liqing , Shen Xin , Zhou Xiaogang , Cao Hui , Feng Jing , Lei Zihui , Tian Kunming , Liang Jiarui , Wang Yuan , Lu Zuxun , Gan Yong 
Published: September 2021

Background: Home quarantine is an important strategy to contain the mass spread of the coronavirus disease 2019 (COVID-19) pandemic. However, there are a dearth of studies on the prevalence and risk factors of home quarantine strategy implementation among residents. This study aims to assess the state of home quarantine strategy implementation among Chinese residents, which could provide a reference for quarantine policymakers around the world during the pandemic.Method: We conducted a cross-sectional survey of 3,398 residents in China by adopting a convenience sampling strategy. We measured the prevalence and risk factors of home quarantine strategy implementation with the Center for Epidemiological Studies-Depression Scale (CES-D), 10-item Connor-Davidson Resilience Scale (CD-RISC 10), and Perceived Social Support Scale (PSSS). A multivariable model was used to determine the factors associated with home quarantine strategy implementation.Results: A total of 2,936 (86.4%) respondents carried out home quarantine. There were some factors significantly associated with home quarantine strategy implementation among Chinese residents during the COVID-19 outbreak. Respondents who were male, lived in western and central China, were aware of the primary symptoms of COVID-19, were willing to accept recommendations on relevant protective measures, understood local quarantine measures, had better resilience, and had better social support were more likely to engage in home quarantine. Respondents who were married, were employed, were healthy, and had high depression scores were more likely to refuse to follow home quarantine guidance.Conclusions: Gender, region, marital status, employment status, health status, awareness of the primary symptoms of COVID-19, willingness to accept recommendations on relevant protective measures, understanding of local quarantine measures, depression, psychological resilience, and perceived social support were the main factors affecting the implementation of residents' home quarantine strategy. Health service policymakers should adopt relevant measures to improve the prevalence of home quarantine strategy implementation among residents during the pandemic.
VR Health Experience: A Virtual Space for Arts and Psychomotor Therapy
Authors: Haeyen Suzanne , Jans Nathalie , Glas Marleen , Kolijn Joep 
Published: September 2021

Introduction: Mental health and well-being are under pressure because of the corona pandemic. Arts and psychomotor therapists said that they had almost no experience with working online, but despite the fact that they felt incapable, they were positive towards it.Method: This qualitative action research was aimed at how arts and psychomotor therapists can become more skilled in offering online arts and psychomotor therapy and how they can methodically enlist the VR Health Experience (a virtual arts and psychomotor therapy space) in therapy. It is envisaged that the arts and psychomotor therapist could be telepresent in order to offer arts and psychomotor therapy remotely. In online training that made use of the Lean Startup Method, participants (n = 5) integrated their working knowledge with the VR Health Experience. The interventions were immediately tested by the participants and in practice. Participants were interviewed retrospectively and their experiences were thematically analysed.Results: The VR Health Experience came forward as an innovative addition to the usual arts and psychomotor therapy. Often, clients were encouraged to play and experiment, and the VR world offered several options. The VR Health Experience lowered the threshold, expanded the training areas and held a great attraction for play.Discussion: This project offered an innovative quality boost for arts and psychomotor therapy. Arts and psychomotor therapy have proven to be possible remotely via telepresence of the therapist. The therapist is present together with the client in the VR Health Experience, the virtual arts and psychomotor therapy space, where connectedness can be felt and new experiences can be gained. VR also offers further possibilities in arts and psychomotor therapy.
Basic Reproduction Number of the 2019 Novel Coronavirus Disease in the Major Endemic Areas of China: A Latent Profile Analysis
Authors: Xu Honglv , Zhang Yi , Yuan Min , Ma Liya , Liu Meng , Gan Hong , Liu Wenwen , Lum Gillian Gianna Anne , Tao Fangbiao 
Published: September 2021

Objective: The aim of this study is to analyze the latent class of basic reproduction number (R0) trends of the 2019 novel coronavirus disease (COVID-19) in the major endemic areas of China.Methods: The provinces that reported more than 500 cases of COVID-19 till February 18, 2020 were selected as the major endemic areas. The Verhulst model was used to fit the growth rate of cumulative confirmed cases. The R0 of COVID-19 was calculated using the parameters of severe acute respiratory syndrome (SARS) and COVID-19. The latent class of R0 was analyzed using the latent profile analysis (LPA) model.Results: The median R0 calculated from the SARS and COVID-19 parameters were 1.84–3.18 and 1.74–2.91, respectively. The R0 calculated from the SARS parameters was greater than that calculated from the COVID-19 parameters (Z = −4.782 to −4.623, p &lt; 0.01). Both R0 can be divided into three latent classes. The initial value of R0 in class 1 (Shandong Province, Sichuan Province, and Chongqing Municipality) was relatively low and decreased slowly. The initial value of R0 in class 2 (Anhui Province, Hunan Province, Jiangxi Province, Henan Province, Zhejiang Province, Guangdong Province, and Jiangsu Province) was relatively high and decreased rapidly. Moreover, the initial R0 value of class 3 (Hubei Province) was in the range between that of classes 1 and 2, but the higher R0 level lasted longer and decreased slowly.Conclusion: The results indicated that the overall R0 trend is decreased with the strengthening of comprehensive prevention and control measures of China for COVID-19, however, there are regional differences.
Percutaneous Mechanical Atherectomy Plus Thrombectomy Using the Rotarex®S Device Followed by a Drug-Coated Balloon for the Treatment of Femoropopliteal Artery In-stent Restenosis: A Prospective Single-Center, Single-Arm Efficacy Trial (PERMIT-ISR Trial)
Authors: Liu Ming-Yuan , Li Wenrui , Guo Xiaobo , Zhang Zhiwen , Liu Bin , Yu Hongzhi , Zhang Zhe , Chen Xueming , Feng Hai 
Published: September 2021

Background: Studies investigating debulking devices with drug-coated balloons (DCBs) in the treatment of femoropopliteal (FP) artery in-stent restenosis (ISR) are limited. We aimed to evaluate the safety and midterm outcome of percutaneous mechanical atherectomy plus thrombectomy (MATH) using the Rotarex®S (Straub Medical, Wangs, Switzerland) catheter followed by a DCB in the treatment of FP-ISR.Methods: This study was a single-center single-arm trial. Patients with symptomatic (Rutherford category 2–5) de novo restenosis lesions of FP-ISR were treated with MATH and subsequent DCB. From June 2016 to May 2018, 59 patients with FP-ISR were enrolled. The primary endpoint was target lesion revascularization (TLR) and changes in the Rutherford category of the target limb at 12 months. Secondary endpoints included primary and secondary patency at 12 months, technical success rate, major adverse events, and ankle-brachial index (ABI). Risk factors for TLR were analyzed using Cox proportional hazard model.Results: The average follow-up time was 33 ± 8 months. The rate of technical success was 88.1% (52/59). Nine patients received bailout stenting. The rate of freedom from TLR was 84.7% (50/59) at 1 year, the Rutherford category changed at 12 months were significantly improved from baseline (p &lt; 0.01). The primary patency rates and the secondary patency at the 12-month follow-ups were 82.5 and 92.5%, respectively. The ABI changed at 12 months were significantly improved from baseline (p &lt; 0.01). Global limb anatomic staging system (GLASS) classification III [hazard ratio (HR) 18.44, 95% CI (1.57–215.99), p = 0.020] and postoperative Rutherford classification ≥4 [HR 8.28, 95% CI (1.85–37.06), p = 0.006] were identified as independent predictors of TLR.Conclusion: Our preliminary data suggested that MATH using a Rotarex®S catheter combined with DCB angioplasty is a safe, minimally invasive, and effective treatment for FP-ISR with favorable, immediate, and midterm outcomes.Clinical Trial Registration:http://www.chictr.org.cn, identifier [ChiCTR2000041380].
Case Report: Successful Treatment of Sarcoptic Mange in European Camelids
Authors: Deak Georgiana , Moroni Barbara , Boncea Ana Maria , Rambozzi Luisa , Rossi Luca , Mihalca Andrei Daniel 
Published: September 2021

Introduction: Members of the Camelidae family are very adaptable mammals, originating from South America. More recently, they have become popular in Europe as pets or wool production farm animals. Their dermatological problems refer mainly to mange, of which sarcoptic mange represent the most clinically relevant form. There is a wide range of molecules effective against sarcoptic mange, but the treatment is very challenging due to the lack of efficiency and absorption.Methods: Two cases from two different animal populations were described. A female alpaca from Romania with dermatological problems on the ears and two adult llamas, from Italy, both with intense pruritus. Combined treatment with amitraz and subcutaneous eprinomectin was administered for the alpaca, and 2% moxidectin was given to the llamas.Results: In both cases, the mites were morphologically identified as Sarcoptes scabiei. For the alpaca, negative scrapings were found only after 8 weeks of combined treatment. For the llamas, after four doses of subcutaneous moxidectin, no mites were detected in scrapings and lively hair regrowth of previously alopecic areas was visible.Conclusion: This paper aimed to present two clinical scenarios of sarcoptic mange in camelids, successfully treated with a combination of ectocides (topical amitraz and subcutaneous eprinomectin) and 2% subcutaneous moxidectin, respectively.
EDUCAÇÕES SELVÁTICAS ENTRE CORPOS E CIDADES
Authors: Sejanes Thalita Alves , Kasper Kátia Maria 
Published: September 2021

Fragmentos de uma dissertação de mestrado, que cartografa o processo de criação do espetáculo Cabaret Macchina, do coletivo Selvática Ações Artísticas. No encontro das artistas com a cidade de Curitiba, esboçam-se pistas a propósito de processos de criação, com seus trajetos, encontros, acasos e ocasiões. Traça-se uma cartografia (DELEUZE; GUATTARI, 1995) dos processos, envolvendo os efeitos dos encontros dos corpos, entre devires da arte e devires da educação. Corpos produzidos na intensidade dos encontros. Especial atenção aos procedimentos das artistas para criar, inventando caminhos e modos de fazer, com abertura radical aos encontros, com humanos e não-humanos. Maquinando também com a ecosofia (GUATTARI, 2011) e a cidade tramada em processos desejantes, com outros modos de aprender e pesquisar, resistindo a tempos brutos. Micropolítica. Sobressaltos. Redes que se criam inventando possibilidades. Desenha-se uma trama aracniana: saberes do corpo, fazer-se rede, movida pelos efeitos de tais encontros. Traçar é agir. (DELIGNY, 2015).
A EXPERIÊNCIA DO FORA EM DELEUZE: O VIRTUAL TECNOLÓGICO E A VIDEOARTE
Authors: Souza Garcia Ramos Hugo , Rosa Coelho Geide 
Published: September 2021

Este artigo objetiva problematizar a experiência do fora por meio da videoarte. Essa proposição implica compreender que a arte do vídeo pode ser um “veículo” potente para acionar devires da subjetivação que tem modificado os modos de experimentação de si e do mundo. Para tanto, é abordada as temáticas do virtual e da imagem-tempo a partir do pensamento de Deleuze (1987; 1988; 1990). Além disso, foi realizada uma análise dos territórios sensíveis da obra videográfica Mannequin Death (2016) de John Miller e Richard Hoeck. Concluímos, ao final, que devido as imagens de uma videoarte serem regidas sob o signo do inacabamento – uma obra-processo em que a plasticidade ganha lugar, características da vida, se instaura a possibilidade para transitar por uma experiência fora do sujeito nas dimensões do virtual. O que ocorre é um outro agenciamento com espectador em que há múltiplas produções de sentidos e linguagens sem pretensão de estabelecer sistemas de representação.
Study on the Degreasing of Sheep Skin Using Subcritical Fluid Extraction
Authors: Xia Qiao , Zhang Meina , Mao Bo , Dai Hong , Zhang Zongcai 
Published: September 2021

Degreasing is one of the important processes for the production of leather and fur. This study aimed to develop a degreasing method using subcritical n-pentane. Sheep skin was chosen as raw skin for this investigation. The best possible combination of degreasing parameters was found using single factor experiment and response surface methodology. The effects of temperature and pressure on the degreasing efficiency were evaluated further with histological analysis. The results showed that the optimum degreasing parameters were a degreasing time of 58 min, pressure of 0.45 MPa, temperature of 41.0°C and thus yielded a degreasing rate of 52.46％ theoretically and 51.46% experimentally. Histological sections showed that the degreasing effect of subcritical n-pentane was quite significant and the lipid droplets around the hair follicles were dramatically reduced. It has been proven that subcritical n-pentane degreasing is an effective technique for sheep skin degreasing.
Thermal Characterization and Pyrolysis of Waste Leather Treated with CoCl₂ And MnC₂
Authors: Bañón E. , Torró A. , García A. N. , León M. , Marcilla A. 
Published: September 2021

Leather tanned with different agents was pyrolyzed in the presence of CoCl2 and MnCl2 catalysts. A bovine leather sample tanned with two inorganic tanning agents (chromium and titanium salts) and two organic tanning agents (glutaraldehyde and methylacrylic resin) has been used in this study. The samples were soaked in solutions of CoCl2 or MnCl2 of known concentration. The influence on decomposition temperature and the resultant pyrolysis compounds has been evaluated by using thermogravimetric analysis (TG/DTG) and flash pyrolysis (Py-GC/MS). A multivariate analysis has been applied to the pyrolysis products obtained confirming the effect of the catalyst treatment on leather,
Oxidized Maltodextrin: A Novel Ligand for Aluminum–Zirconium Complex Tanning
Authors: Guo Xuero , Yu Yue , Wang Ya-nan , Shi Bi 
Published: September 2021

Hydrogen peroxide (H2O2) oxidized maltodextrin was prepared as the ligand for aluminum–zirconium complex tanning. The effects of catalyst dosage, initiation temperature, and H2O2 dosage on maltodextrin oxidation were investigated. FT-IR analysis demonstrated that carboxyl groups were successfully introduced into oxidized maltodextrin. The carboxyl content and degradation degree of oxidized maltodextrin increased with the increase of H2O2 dosage. Maltodextrin oxidized by 40% H2O2 and 0.015% Cu–Fe catalyst at an initiation temperature of 70°C (OD-40) with moderate carboxyl group (6.75 mmol/g) and molecular weight (Mw 450) promoted the penetration and fixation of aluminum–zirconium salts in leather and showed better tanning performance, such as hydrothermal stability and porosity of leather, than traditional citric acid ligand.
Marca país Ecuador: confusión y renovación
Authors: Pérez Peña Oscar Alberto , Aguirre Montalvo Verónica Mireya , Malave Quintana Nancy 
Published: September 2021

El presente ensayo tiene como objetivo valorar la importancia que poseen las instituciones jurídicas de confusión y renovación en el derecho marcario, en particular, respecto a la marca país Ecuador. En el estudio son abordadas la definicion, ventajas e importancia del reconocimiento jurídico de la marca país, dentro del derecho de propiedad industrial de ecuatoriano, en base a instrumentos internacionales que protegen las marcas a nivel mundial. Se aborda la normativa nacional, que abarca desde la Constitución hasta el Código Orgánico de la Economía Social de los Conocimientos, la Creatividad y la Innovación de 2016. Al establecer las bases de estudio en la legislacion nacional e internacional, se realiza la interrogante acerca de si la marca país genera confusión en el derecho marcario nacional, a partir de las diversas controversias que ha generado. Se concluye respondiendo a otra interrogante: ¿Es necesaria la renovación de la marca país Ecuador?.
De la estructura del párrafo hacia la organización discursiva: consideraciones teórico-prácticas
Authors: Sorókina Tatiana 
Published: September 2021

La consideración central de este trabajo reside en que las ideas-hechos pueden ser formalizadas en el nivel de una unidad discursiva mínima que es el párrafo. Éste, si se trata de discursos argumentativos, tiene una determinada estructura (circular) que, desde la misma expresión y de manera “económica”, permite procesar y comprender la idea formalizada. Los párrafos-ideas, a su vez, también se vinculan entre sí de manera coherente, debido precisamente a su estructura (y coherencia) interna. Este mecanismo puede relacionarse con la construcción (o la alineación) del conocimiento en general. No exploramos la composición de los textos de índole literaria, sin embargo, creemos que el análisis estructural de este género puede revelar con mayor obviedad la estructura del conocimiento, pues las obras de arte verbal se crean no sólo a base de la lógica, también a base de las asociaciones.