bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viable and not viable spore concentrations in National Gallery of Umbria (Italy)
Authors: Ruga Luigia , Orlandi Fabio , Fornaciari Marco 
Published: March 2021

AbstractThe conservation actions towards artworks holding a common patrimony for the community are of primary importance, but also those related to their "container" as museums, libraries or archives are to consider. Fungal spores and bacteria carried by air flows to the artwork surface can colonize it causing biodeterioration through physical and/or chemical alterations of the materials with the irreversible loss of their value. The quality control of the indoor air surrounding the historic building is essential, as well as for the protection and conservation of the artwork, also for the protection of the health of operators and visitors. The aim of this study was to monitor airborne fungal particles, through volumetric spore traps, for improving the knowledge about the conservation and protection of artworks in the museum environment analysing the principal relationships between indoor environmental conditions and potentially biodeteriogen fungal spore growth. The evidence of no significant relationships between spore concentrations and environmental conditions recorded inside the different expositive rooms testified the regular and correct maintenance of the air conditioning system inside the considered building (National Gallery of Umbria, central Italy). Moreover, in a specific museum room a significant spore concentration decreasing trend was recorded mainly due to a structural modification in the same building.
Lattices over Bass Rings and Graph Agglomerations
Authors: Baeth Nicholas R. , Smertnig Daniel 
Published: March 2021

AbstractWe study direct-sum decompositions of torsion-free, finitely generated modules over a (commutative) Bass ring R through the factorization theory of the corresponding monoid T(R). Results of Levy–Wiegand and Levy–Odenthal together with a study of the local case yield an explicit description of T(R). The monoid is typically neither factorial nor cancellative. Nevertheless, we construct a transfer homomorphism to a monoid of graph agglomerations—a natural class of monoids serving as combinatorial models for the factorization theory of T(R). As a consequence, the monoid T(R) is transfer Krull of finite type and several finiteness results on arithmetical invariants apply. We also establish results on the elasticity of T(R) and characterize when T(R) is half-factorial. (Factoriality, that is, torsion-free Krull–Remak–Schmidt–Azumaya, is characterized by a theorem of Levy–Odenthal.) The monoids of graph agglomerations introduced here are also of independent interest.
Phase 2 study of TAS-117, an allosteric akt inhibitor in advanced solid tumors harboring phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homolog gene mutations
Authors: Lee Jii Bum , Jung Minkyu , Beom Seung Hoon , Kim Gun Min , Kim Hye Ryun , Choi Hye Jin , Sohn Joo Hyuk , Ahn Joong Bae , Rha Sun Young , Chung Hyun Cheol 
Published: March 2021

SummaryTAS-117 is a potent and selective allosteric pan-v-akt murine thymoma viral oncogene homolog (Akt) inhibitor. We conducted a single-arm single-center phase 2 study of TAS-117 in heavily treated patients with tumors refractory to systemic chemotherapy and harboring phosphatidylinositol 3-kinase (PI3K)/Akt mutations. Patients with gastrointestinal (GI) cancers were orally administered 16 mg TAS-117 daily, and those with non-GI tumors were administered 24 mg on a 4 days on/3 days off schedule. The primary endpoint was overall response rate (ORR). Secondary endpoints included disease control rate (DCR), progression-free survival (PFS), overall survival (OS), PFS ratio, safety, and tolerability. Thirteen patients were enrolled: eight with non-GI (breast, ovarian, endometrial, and non-small cell lung) and five with GI (colon, rectal, gastric, and gallbladder) cancers. Ten patients were treated with TAS-117 after ≥ 4 lines of therapy. Twelve patients showed PIK3 catalytic subunit alpha (PIK3CA) mutations; one harbored an Akt1E17K mutation. The median treatment duration was 1.4 months; the median number of treatment cycles was 2. The ORR was 8 %, and DCR was 23 %. The median PFS and OS were 1.4 and 4.8 months, respectively. Grade 3–4 treatment-related adverse events were anorexia (grade 3, 8 %) and hyperglycemia (grade 3, 8 %; grade 4, 8 %).Grade 3–4 treatment-related adverse events occurred in 27 % of grade 3 anorexia (9 %) and hyperglycemia (grade 3, 8 %; grade 4, 9\%). TAS-117 showed limited antitumor activity and manageable toxicity. Clinical efficacy was observed in patients with ovarian cancer harboring PIK3CA E545K mutations and in patients with breast cancer harboring PIK3CA H1047R and Akt1E17K mutations.Trial registration: This study was retrospectively registered with ClinicalTrial.gov (NCT03017521 on January 11, 2017).
An Intrinsic Material Tailoring Approach for Functionally Graded Axisymmetric Hollow Bodies Under Plane Elasticity
Authors: Abdalla Hassan Mohamed Abdelalim , Casagrande Daniele 
Published: March 2021

AbstractOne of the main requirements in the design of structures made of functionally graded materials is their best response when used in an actual environment. This optimum behaviour may be achieved by searching for the optimal variation of the mechanical and physical properties along which the material compositionally grades. In the works available in the literature, the solution of such an optimization problem usually is obtained by searching for the values of the so called heterogeneity factors (characterizing the expression of the property variations) such that an objective function is minimized. Results, however, do not necessarily guarantee realistic structures and may give rise to unfeasible volume fractions if mapped into a micromechanical model. This paper is motivated by the confidence that a more intrinsic optimization problem should a priori consist in the search for the constituents’ volume fractions rather than tuning parameters for prefixed classes of property variations. Obtaining a solution for such a class of problem requires tools borrowed from dynamic optimization theory. More precisely, herein the so-called Pontryagin Minimum Principle is used, which leads to unexpected results in terms of the derivative of constituents’ volume fractions, regardless of the involved micromechanical model. In particular, along this line of investigation, the optimization problem for axisymmetric bodies subject to internal pressure and for which plane elasticity holds is formulated and analytically solved. The material is assumed to be functionally graded in the radial direction and the goal is to find the gradation that minimizes the maximum equivalent stress. A numerical example on internally pressurized functionally graded cylinders is also performed. The corresponding solution is found to perform better than volume fraction profiles commonly employed in the literature.
The efficacy of catheter ablation versus ICD for prevention of ventricular tachycardia in patients with ischemic heart disease: a systematic review and meta-analysis
Authors: Liu Guolin , Xu Xin , Yi Qijian , Lv Tiewei 
Published: March 2021

Abstract
Purpose
Although implantable cardioverter defibrillator (ICD) could prevent the sudden death of ventricular tachycardia (VT) in patients with ischemic heart disease, it could not effectively prevent the recurrence of ventricular tachycardia. Several studies have suggested that catheter ablation may effectively decrease the incidence of ICD events, but relevant dates from randomized controlled trials were limited.

Methods
A systematic review and meta-analysis of randomized controlled trials were performed to evaluate the effect of catheter ablation for the prevention of VT in patients with ischemic heart disease. Random-effects model with inverse-variance weighting method was used to pool odds ratios. Egger method was performed to evaluate whether there was public bias in each outcome.

Results
Four studies enrolling a total of 605 patients were included in the present meta-analysis. Compared with the control group (ICD ± AAD), catheter ablation could significantly reduce the incidence of ICD therapy (OR, 0.49; 95% CI, 0.28 ~ 0.87), ICD shock (OR, 0.50; 95% CI, 0.28 ~ 0.87), VT storm (OR, 0.60; 95% CI, 0.40 ~ 0.90), and cardiovascular-related hospitalization (OR, 0.66; 95% CI, 0.45 ~ 0.9). But there was no significant difference among the risk of all-cause mortality (OR, 0.89; 95% CI, 0.59 ~ 1.34), cardiovascular mortality (OR, 0.76; 95% CI, 0.44 ~ 1.30), and complication (OR, 0.89; 95% CI, 0.30 ~ 2.67).

Conclusion
These results showed that catheter ablation combined with ICD could reduce ICD therapy, ICD shock, and VT storm in patients with ischemic heart disease, but there was no improvement in all-cause mortality. Meanwhile, it also provided a basic guidance for the design of larger clinical randomized trials with longer follow-up in the future.
Long-term trends of oxygen concentration in the waters in bank and shelves of the Southern Japan Sea
Authors: Ono Tsuneo 
Published: March 2021

AbstractWhile multiple studies have investigated oxygen decrease in Japan Sea Proper Water (JSPW; > 300 m in depth), oxygen variation in continental slope and shelf waters (< 300 m) must also be investigated in order to assess its socioecological impacts. In this study, historical oxygen data in the waters of three continental shelves and a bank of Japan Sea, off-Awashima area (AW), Wakasa Bay (WB), East of Tsushima Straight (ETS), and Yamato Bank (YB), were collected and analyzed to assess temporal variation of oxygen in each region from 1960 to 2000s. Significant decreasing trends of oxygen were detected in the waters below 150 m depth in WB and YB, and below 300 m in AW, in the summer season. In winter, a decreasing trend of oxygen was detected throughout the water column from 300 m to the sea surface in WB and YB. In ETS, a deoxygenation trend was detected throughout the water column from the bottom to the sea surface in the summer season, while no trend was detected in winter. The results suggested that oxygen decreases in AW, WB, and YB were the consequence of the upward propagation of the deoxygenation signal from JSPW, while that of ETS was caused by horizontal propagation of deoxygenation signal from the East China Sea. Assuming that the observed trend will continue in future, it is predicted that part of the water in Tsushima Strait area will reach the general sublethal threshold of oxygen (134 μmol kg−1) by the end of this century.
From hostile worlds to multiple spheres: towards a normative pragmatics of justice for the Googlization of health
Authors: Sharon Tamar 
Published: March 2021

AbstractThe datafication and digitalization of health and medicine has engendered a proliferation of new collaborations between public health institutions and data corporations like Google, Apple, Microsoft and Amazon. Critical perspectives on these new partnerships tend to frame them as an instance of market transgressions by tech giants into the sphere of health and medicine, in line with a “hostile worlds” doctrine that upholds that the borders between market and non-market spheres should be carefully policed. This article seeks to outline the limitations of this common framing for critically understanding the phenomenon of the Googlization of health. In particular, the mobilization of a diversity of non-market value statements in the justification work carried out by actors involved in the Googlization of health indicates the co-presence of additional worlds or spheres in this context, which are not captured by the market vs. non-market dichotomy. It then advances an alternative framework, based on a multiple-sphere ontology that draws on Boltanski and Thevenot’s orders of worth and Michael Walzer’s theory of justice, which I call a normative pragmatics of justice. This framework addresses both the normative deficit in Boltanski and Thevenot’s work and provides an important emphasis on the empirical workings of justice. Finally, I discuss why this framework is better equipped to identify and to address the many risks raised by the Googlization of health and possibly other dimensions of the digitalization and datafication of society.
Psychometric properties of the Polish version of the 36-item WHODAS 2.0 in patients with hip and knee osteoarthritis
Authors: Bejer Agnieszka , Ćwirlej-Sozańska Agnieszka , Wiśniowska-Szurlej Agnieszka , Wilmowska-Pietruszyńska Anna , Spalek Renata , de Sire Alessandro , Sozański Bernard 
Published: March 2021

Abstract
Purpose
To examine psychometric properties of the Polish version of the 36-item WHO Disability Assessment Schedule 2.0 (WHODAS 2.0) in the population with hip and knee osteoarthritis (OA).

Methods
This was a longitudinal study with repeated measures during retest examinations. Subjects from a Polish Specialist Hospital (age = 68.3 ± 9.2years, 71% female, 44.2% knee OA, 55.8% hip OA) were tested three times. They completed the Polish version of the 36-item WHODAS 2.0, the SF-36 Health Survey 2.0, the Western Ontario and Macmaster Universities Osteoarthritis Index 3.1, the Hospital Anxiety and Depression Scale, and the Numerical Rating Scale.

Results
The 36-item WHODAS 2.0—Polish version demonstrated high internal consistency (Cronbach’s alpha for total = 0.94), and test–retest reliability (Total ICC2,1 = 0.98). High construct validity was found as 12 out of 15 a priori hypotheses (80%) were confirmed. Most domains and Total Scores in the 36-item WHODAS 2.0 (Total ES = − 0.62, SMR = − 1.09) showed a moderate degree of responsiveness. Minimal clinically important difference (MCID) for the Total WHODAS 2.0 was 3.29 in patients undergoing rehabilitation for knee or hip OA.

Conclusions
The Polish version of the 36-item WHODAS 2.0 assesses disability according to ICF in a reliable, valid and responsive way. Therefore, it provides considerable support in clinical practice and national and international scientific research of patients with hip or knee OA.
Intentions to quit upper secondary education among first generation immigrants and native Norwegians: the role of loneliness and peer victimization
Authors: Fandrem Hildegunn , Tvedt Maren Stabel , Virtanen Tuomo , Bru Edvin 
Published: March 2021

AbstractDropout from upper secondary education is a persistent educational problem, particularly among first-generation immigrant youth. This study examined factors associated with intentions to dropout to gain further insight into the process of leaving upper secondary education. The analyses of 1299 Norwegian first-year upper secondary school students’ (88% native Norwegians, 12% first-generation immigrants) self-reported intentions to quit school, loneliness, and peer victimization in school showed that first-generation immigrants experienced higher levels of loneliness than native Norwegians. In contrast, there were no differences in the levels of peer victimization and intentions to quit between native Norwegians and first-generation immigrants. However, loneliness showed a significantly stronger association with intentions to quit among first-generation immigrants. The results underscore the importance of tackling first-generation immigrants’ loneliness in school to reduce their intentions to quit upper secondary education and thus potentially improve conditions for school completion.
How to have a metalinguistic dispute
Authors: Mankowitz Poppy 
Published: March 2021

AbstractThere has been recent interest in the idea that speakers who appear to be having a verbal dispute may in fact be engaged in ametalinguistic negotiation: they are communicating information about how they believe an expression should be used. For example, individuals involved in a dispute about whether a racehorse is an athlete might be communicating their diverging views about how ‘athlete’ should be used. While many have argued that metalinguistic negotiation is a pervasive feature of philosophical and everyday discourse, the literature currently lacks an account of this phenomenon that can be situated within a ‘mainstream’ view of communication. I propose an independently motivated account where individuals reconstruct metalinguistic propositions by means of a pragmatic, Gricean reasoning process.
Taking values seriously
Authors: Bykvist Krister 
Published: March 2021

AbstractRecently, there has been a revival in taking empirical magnitudes seriously. Weights, heights, velocities and the like have been accepted as abstract entities in their own right rather than just equivalence classes of objects. The aim of my paper is to show that this revival should includevaluemagnitudes. If we posit such magnitudes, important value comparisons (cross-world, cross-time, mind to world, cross-theory, cross-polarity, ratio) can be easily explained; it becomes easier to satisfy the axioms for measurement of value; goodness, badness, and neutrality can be given univocal definitions; value aggregation can be given a non-mathematical understanding which allows for Moorean organic unities. Of course, this does not come for free. One has to accept a rich ontology of abstract value magnitudes, but, to quote David Lewis, ‘The price is right; the benefits in theoretical unity and economy are well worth the entities.’
Perturbation Solution for One-Dimensional Flow to a Constant-Pressure Boundary in a Stress-Sensitive Reservoir
Authors: Bhullar Amarjot Singh , Stewart Gospel Ezekiel , Zimmerman Robert W. 
Published: March 2021

Abstract
Most analyses of fluid flow in porous media are conducted under the assumption that the permeability is constant. In some “stress-sensitive” rock formations, however, the variation of permeability with pore fluid pressure is sufficiently large that it needs to be accounted for in the analysis. Accounting for the variation of permeability with pore pressure renders the pressure diffusion equation nonlinear and not amenable to exact analytical solutions. In this paper, the regular perturbation approach is used to develop an approximate solution to the problem of flow to a linear constant-pressure boundary, in a formation whose permeability varies exponentially with pore pressure. The perturbation parameter αD is defined to be the natural logarithm of the ratio of the initial permeability to the permeability at the outflow boundary. The zeroth-order and first-order perturbation solutions are computed, from which the flux at the outflow boundary is found. An effective permeability is then determined such that, when inserted into the analytical solution for the mathematically linear problem, it yields a flux that is exact to at least first order in αD. When compared to numerical solutions of the problem, the result has 5% accuracy out to values of αD of about 2—a much larger range of accuracy than is usually achieved in similar problems. Finally, an explanation is given of why the change of variables proposed by Kikani and Pedrosa, which leads to highly accurate zeroth-order perturbation solutions in radial flow problems, does not yield an accurate result for one-dimensional flow.

Article Highlights

Approximate solution for flow to a constant-pressure boundary in a porous medium whose permeability varies exponentially with pressure.

The predicted flowrate is accurate to within 5% for a wide range of permeability
variations.

If permeability at boundary is 30% less than initial permeability, flowrate will be 10% less than predicted by constant-permeability model.
Emotion, Epistemic Assessability, and Double Intentionality
Authors: Magalotti Tricia , Kriegel Uriah 
Published: March 2021

AbstractEmotions seem to be epistemically assessable: fear of an onrushing truck is epistemically justified whereas,mutatis mutandis, fear of a peanut rolling on the floor is not. But there is a difficulty in understanding whyemotions are epistemically assessable. It is clear why beliefs, for instance, are epistemically assessable: epistemic assessability is, arguably, assessability with respect to likely truth, and belief is by its nature concerned with truth; truth is, we might say, belief’s “formal object.” Emotions, however, have formal objects different from truth: the formal object of fear is danger, the formal object of indignation is injustice, and so on. Why, then, are emotions epistemically assessable too? Here we make a negative claim and a positive claim. On the negative side, we consider how cognitivist and perceptualist accounts of emotion may respond to this challenge, and argue against those responses. On the positive side, we develop an alternative picture of the domain of the epistemically evaluable, according to which any mental state which is constitutively evidence-responsive is epistemically assessable, regardless of whether its formal object is truth.
Scleractinian corals incorporate microplastic particles: identification from a laboratory study
Authors: Hierl Florian , Wu Henry C. , Westphal Hildegard 
Published: March 2021

AbstractMicroplastics have been detected on beaches and in the ocean from surface habitats to the deep-sea. Microplastics can be mistaken for food items by marine organisms, posing a potential risk for bioaccumulation and biomagnification in the food chain. Our understanding of microplastic pollution effects on ecosystem and physiological processes of coral reefs is still limited. This study contributes to the understanding of effects of microplastic pollution on skeletal precipitation of hermatypic corals. In a five month aquarium-based experiment, specimens of four tropical species were temporarily exposed to high concentrations (ca. 0.5 g L-1) of polyethylene terephthalate (PET) microplastic particles (< 500 μm). The coral specimens all survived this treatment and show skeletal growth. The skeletal material produced during the experiment, however, incorporated plastic particles and plastic fibres in the aragonitic structure. Long-term consequences of such inclusions on skeletal properties such as stability are yet unknown.
Efficacy and safety of ferric citrate hydrate compared with sodium ferrous citrate in Japanese patients with iron deficiency anemia: a randomized, double-blind, phase 3 non-inferiority study
Authors: Komatsu Norio , Arita Kojo , Mitsui Hironori , Nemoto Takanori , Hanaki Koji 
Published: March 2021

AbstractOral iron preparations are used as first-line treatment for iron deficiency anemia (IDA), but their gastrointestinal side effects prevent patients from appropriate adherence. We recently conducted a randomized, double-blind, phase 3 non-inferiority study to evaluate the efficacy and safety of two dosages of ferric citrate hydrate (FC) compared with sodium ferrous citrate (SF) in patients with IDA. FC at both 500 and 1000 mg/day was non-inferior to SF at 100 mg/day in terms of the change in the hemoglobin concentration at Week 7 from baseline. Logistic regression analysis suggested that the cumulative proportion of patients who achieved the target hemoglobin concentration (≥ 13.0 g/dL in male patients and ≥ 12.0 g/dL in female patients) at Week 7 was highest among those treated with FC at 1000 mg/day, followed by SF at 100 mg/day and FC at 500 mg/day. Both dosages of FC were well tolerated in patients with IDA. The incidences of nausea and vomiting were significantly lower in the FC treatment groups than in the SF group. In conclusion, FC has potential to be an oral iron preparation with sufficient efficacy for the treatment of IDA and a lower risk of nausea and vomiting.