bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revealing the Thermal Safety of Prussian Blue Cathode for Safer Nonaqueous Batteries
Authors: Li Zheng , Dadsetan Mehran , Gao Junxian , Zhang Sensen , Cai Lirong , Naseri Ali , Jimenez‐Castaneda Martha E. , Filley Timothy , Miller Jeffrey T. , Thomson Murray J. , Pol Vilas G. 
Published: October 2021

AbstractPrussian blue analogs (PBAs) are promising cathode materials for many next‐generation metal‐ion batteries due to their exceptional electrochemical performance. Their oxygen‐free structure avoids a common battery thermal runaway pathway which requires O2 liberation. Herein, the thermal runaway mechanisms of PBAs are studied from the level of material and full cell in nonaqueous sodium‐ and potassium‐ion batteries (SIBs and KIBs). Their hidden safety issue and a novel runaway mechanism that requires no oxygen evolution are identified. The cyanide groups are released (≈51.4 wt%) as toxic cyanides above 200 °C, which also exothermically react with the electrolyte and cause the runaway. The cyanide gas generation mechanism is proposed as cathode hydrolytic disproportionation by Raman spectroscopy, X‐ray photoelectron spectroscopy, in situ environmental transmission electron microscopy, and operando synchrotron X‐ray diffraction studies. In addition, full‐cell level calorimetric studies reveal mitigated heat generation but lower initiation temperature of runaway from such SIBs and KIBs than conventional LiCoO2–graphite system. These results change how PBA materials are evaluated from a safety standpoint, suggesting that they cannot be regarded as safe cathodes. They also indicate the correlations between thermal safety and their crystal defects or trapped water content. The proposed thermal runaway mechanism provides insights to assist in the building of safer next‐generation batteries.
The cotton GhMYB4 gene enhances salt and drought tolerance in transgenic Arabidopsis
Authors: Wang Zunxin , Li Yang , Hu Laibao , Ye Yuxiu , Chen Jiamin , Li Jianan , Pei Baolei , Wang Guangpeng , Chen Siyuan , Cheng Yanhong , Huang Ganlong , Chen Xinhong , Wang Feibing 
Published: October 2021

AbstractSalt and drought stresses are major environmental pressures in agriculture worldwide and affect crop productivity and quality. The previous reports of the R2R3‐MYB transcription factor (TF) genes found that overexpression of these TF genes regulated the expression of key enzyme‐encoding genes of flavonoid biosynthesis pathway, leading to the increased flavonoid accumulation. However, the roles of the cotton (Gossypium hirsutum L.) R2R3‐MYB transcription factor gene GhMYB4 in regulating flavonoid accumulation and abiotic stress tolerance have not been investigated. In this study, the GhMYB4 gene was isolated from cotton. The observed subcellular localization in onion (Allium cepa L.) epidermal cells demonstrated that GhMYB4 was concentrated in the nucleus. A transactivation assay showed that this gene was transcriptionally active. The increased flavonoid accumulation and enhanced salt and drought tolerance of Arabidopsis overexpression plants were revealed. Under salt and drought stresses, proline and soluble sugar contents significantly increased, whereas H2O2 and malondialdehyde contents significantly decreased in transgenic plants. Further enzymatic analysis showed significant increases of superoxide dismutase, catalase, ascorbate peroxidase, and peroxidase activities in transgenic plants. Real‐time quantitative polymerase chain reaction analysis showed that overexpression of GhMYB4 up‐regulated the genes involved in flavonoid biosynthesis, proline biosynthesis, and reactive oxygen species scavenging in plants under salt and drought stresses. The overall results demonstrate that GhMYB4 has the potential to promote production of growth‐benefiting flavonoids and improve tolerance to abiotic stresses in plants.
A study on genotype × environment interactions for the multiple traits of maize hybrids in China
Authors: Yue Haiwang , Jiang Xuwen , Wei Jianwei , Xie Junliang , Chen Shuping , Peng Haicheng , Bu Junzhou 
Published: October 2021

AbstractThe correct interpretation of the adaptability and stability of maize (Zea mays L.) hybrids in different ecological environments is very important for plant breeders. Additive main effect and multiplicative interaction model and genotype main effects and genotype × environment interaction biplot are the two most popular methods in the analysis of genotype × environment interaction in multienvironment trials. We conducted an experiment designed to examine and evaluate the adaptability and stability of four agronomic traits of 19 tested maize genotypes in two consecutive growth cycles across seven provinces including 37 locations using a randomized completely block design with three replicates. The combined ANOVA for all traits showed that the effect of genotype, environment, and genotype × environment interaction were significant at 0.1% probability levels. In order to evaluate multiple agronomic traits more accurately, multitrait stability index (MTSI) as an emerging selection method based on mean performance and stability was adopted. Agronomic trait grain yield (GY) was positively correlated with grain weight per ear and growth period. In addition, it was also found that GY and bar tip length showed obvious negative correlation. The MTSI is very helpful for breeders who hope to select mean performance and stability based on a variety of agronomic traits because it provides a convenient selection process while taking into account the relevant results of the traits.
Inference of reaction kinetics for supercritical water heavy oil upgrading with a two‐phase stirred reactor model
Authors: Raghavan Ashwin , He Ping , Ghoniem Ahmed F. 
Published: October 2021

AbstractWe present the development and application of a two‐phase stirred reactor model for heavy oil upgrading in the presence of supercritical water (SCW), with coupled phase‐specific thermolysis reaction kinetics and multicomponent hydrocarbon–water phase equilibrium. We demonstrate the inference of oil and water phase kinetics parameters for a compact lumped reaction kinetics scheme through the application of this model to two different sets of batch reactor experiments reported in the literature. We infer that, although SCW can suppress the formation of newer polynuclear aromatics (PNA) from distillate range species, it is broadly ineffective in deterring the combination of pre‐existing PNA fragments in the oil feed. Quantification of the conversion to distillate liquids before the onset of coke formation helps arrive at a clear conclusion on whether the use of SCW in the batch reactor leads to better product outcomes for different oil feeds and operating conditions.
Differential susceptibility of distinct parts of the aquatic plant Nymphoides humboldtiana to herbivory supports the optimal defense theory
Authors: Nocchi Nathália , Pereira Renato C. , Duarte Heitor M. , Clavico Etiene E. G. , Konno Tatiana U. P. , Soares Angélica R. 
Published: October 2021

AbstractPremiseThe optimal defense theory (ODT) predicts that the allocation of chemical defenses in plants will be concentrated in parts or tissues that are of higher fitness value for the individuals that produce them. Chemicals are known to be allocated to certain parts of aquatic plants, and the morphological architecture of Nymphoides humboldtiana, a species that exposes its parts to different environmental factors and consumers, may be an excellent model to evaluate within‐plant susceptibility to consumers according to the ODT.MethodsUnder laboratory experimental conditions, we evaluated the defensive properties of extracts from vegetative (leaves, rhizomes, roots) and reproductive (long stem internodes, flowers, fruits) parts of N. humboldtiana against consumption by the generalist herbivorous gastropod Biomphalaria glabrata. Extracts were also subjected to chemical analysis by high‐performance liquid chromatography, principal component analysis, and analysis of their relationships to defensive actions.ResultsExtracts of all vegetative and internode (reproductive) parts of N. humboldtiana exhibited defensive properties against B. glabrata, but the long stem internodes exhibited the highest percentage of inhibition. Chemical profiles of these parts were qualitatively and quantitatively different, but a major unidentified compound is presumably responsible for the higher defensive property found in internodes.ConclusionsOur results support the ODT, since chemical defense was more effective in long stem internodes, which have a high fitness value for N. humboldtiana to keep the flowers emerged on the water surface in response to the rapid and dynamic changes in water levels typical of freshwater environments.
Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs
Authors: Min Jaeki , Mayasundari Anand , Keramatnia Fatemeh , Jonchere Barbara , Yang Seung Wook , Jarusiewicz Jamie , Actis Marisa , Das Sourav , Young Brandon , Slavish Jake , Yang Lei , Li Yong , Fu Xiang , Garrett Shalandus H. , Yun Mi‐Kyung , Li Zhenmei , Nithianantham Stanley , Chai Sergio , Chen Taosheng , Shelat Anang , Lee Richard E. , Nishiguchi Gisele , White Stephen W. , Roussel Martine F. , Potts Patrick Ryan , Fischer Marcus , Rankovic Zoran 
Published: October 2021

AbstractTargeting cereblon (CRBN) is currently one of the most frequently reported proteolysis‐targeting chimera (PROTAC) approaches, owing to favorable drug‐like properties of CRBN ligands, immunomodulatory imide drugs (IMiDs). However, IMiDs are known to be inherently unstable, readily undergoing hydrolysis in body fluids. Here we show that IMiDs and IMiD‐based PROTACs rapidly hydrolyze in commonly utilized cell media, which significantly affects their cell efficacy. We designed novel CRBN binders, phenyl glutarimide (PG) analogues, and showed that they retained affinity for CRBN with high ligand efficiency (LE >0.48) and displayed improved chemical stability. Our efforts led to the discovery of PG PROTAC 4 c (SJ995973), a uniquely potent degrader of bromodomain and extra‐terminal (BET) proteins that inhibited the viability of human acute myeloid leukemia MV4‐11 cells at low picomolar concentrations (IC50=3 pM; BRD4 DC50=0.87 nM). These findings strongly support the utility of PG derivatives in the design of CRBN‐directed PROTACs.
The data paper as a sociolinguistic epistemic object: A content analysis on the rhetorical moves used in data paper abstracts
Authors: Li Kai , Jiao Chenyue 
Published: October 2021

AbstractThe data paper is an emerging academic genre that focuses on the description of research data objects. However, there is a lack of empirical knowledge about this rising genre in quantitative science studies, particularly from the perspective of its linguistic features. To fill this gap, this research aims to offer a first quantitative examination of which rhetorical moves—rhetorical units performing a coherent narrative function—are used in data paper abstracts, as well as how these moves are used. To this end, we developed a new classification scheme for rhetorical moves in data paper abstracts by expanding a well‐received system that focuses on English‐language research article abstracts. We used this expanded scheme to classify and analyze rhetorical moves used in two flagship data journals, Scientific Data and Data in Brief. We found that data papers exhibit a combination of introduction, method, results, and discussion‐ and data‐oriented moves and that the usage differences between the journals can be largely explained by journal policies concerning abstract and paper structure. This research offers a novel examination of how the data paper, a data‐oriented knowledge representation, is composed, which greatly contributes to a deeper understanding of research data and its publication in the scholarly communication system.
Hybride Konstruktionen an der BTU Cottbus‐Senftenberg
Authors: Bleicher Achim , Schauer Thomas , Jirasek Robert , Höltke Tim , Zhang Yangwen , Marker Paul , Wulff Wulf , Manfrecola Johannes , Schmidt Therese 
Published: October 2021

AbstractDie angestrebten Ziele einer Ressourcen‐ und Klimaneutralität erfordern ein radikaleres Umdenken der Bauschaffenden, das mit einer noch viel stärkeren Sensibilisierung der Auftraggeber für die Auswirkungen des Material‐ und Energieverbrauchs im Bausektor verbunden ist. Ein Ansatz, um diese Ziele zu erreichen, sind hybride Konstruktionen, in denen unterschiedliche Materialien, Elemente, Funktionen und Technologien auf mehreren Konstruktionsebenen ressourcen‐ und energieeffizient kombiniert sowie im Fall eines Rückbaus sortenrein rezykliert werden. Dieser anspruchsvolle Ansatz ist von Beginn an erklärtes Ziel des Lehrstuhls Hybride Konstruktionen – Massivbau an der BTU Cottbus‐Senftenberg und zieht sich durch alle Lehr‐ und Forschungsaktivitäten. Mit ausgewählten Forschungsprojekten werden Motivation und Methoden hybrider Konstruktionen sowie deren Potenzial für ressourcen‐ und klimaneutrale Konstruktionen anhand von Prototypen aufgezeigt. Hierbei steht neben der ökologischen Weiterentwicklung klassischer hybrider Konstruktionen aus nachwachsenden und rezyklierten Rohstoffen, bspw. Holz und Recyclingbeton, auch die Entwicklung aktiver hybrider Konstruktionen im Fokus. Die gezielte Integration von aktiven Technologien wie Sensorik, Aktuatorik und Regelungstechnik ermöglicht multifunktionale Konstruktionen, einen hohen Nutzungskomfort, einen geringeren Rohstoffverbrauch bis hin zur Energiegewinnung aus dynamischen Einwirkungen.
Biotechnological and industrial applications of Streptomyces metabolites
Authors: Khushboo  , Kumar Punit , Dubey Kashyap K. , Usmani Zeba , Sharma Minaxi , Gupta Vijai Kumar 
Published: October 2021

Abstract
Streptomyces sp. produces clinically important bioactive compounds with anticancer, antiviral, and antibacterial properties. These compounds have important roles in various fields like agriculture, and medicine, with bio‐economic benefits. Progress in genome mining has resulted in the characterization of various secondary metabolites such as lipstatin, macrolide lactones, clavulanic acid, and cholesterol oxidase. Integration of DNA sequencing with computational tools has provided information regarding the biosynthetic pathways of secondary metabolites. This information is leading to the modulation of associated metabolic pathways to expand the biotechnological and industrial applications of metabolites. The increased utilization of bioactive compounds requires sustainable production to improve the bioeconomy. In this review, the authors discuss the bioactive compounds isolated from Streptomyces and advanced approaches to improve their production. © 2021 Society of Chemical Industry and John Wiley & Sons, Ltd
Effect of advanced glycation end products on nocturia or sleep disorders: A longitudinal study
Authors: Konishi Sakae , Hatakeyama Shingo , Imai Atsushi , Okita Kazutaka , Kido Koichi , Ozaki Yusuke , Uemura Nozomi , Iwane Takuro , Okamoto Teppei , Yamamoto Hayato , Yoneyama Takahiro , Hashimoto Yasuhiro , Ohyama Chikara 
Published: October 2021

AbstractObjectiveThis study aimed to investigate the effect of advanced glycation end products (AGEs) on nocturia and sleep disorders in community‐dwelling adults.Materials and MethodsThis longitudinal study evaluated AGEs level, sleep disorders and nocturia frequency in 447 community‐dwelling adults between May 2011 and May 2016. Sleep disorders were evaluated using the Pittsburgh Sleep Quality Index (PSQI) score. Participants were divided into two groups: AGEs‐low (≤1.80) and AGEs‐high (>1.80). The longitudinal nocturia and PSQI changes for 5 years between the AGEs‐low and AGEs‐high groups were compared. The effect of baseline oxidative stress on worsening of nocturia or PSQI score 5 years later was evaluated using multivariable logistic regression analyses.ResultsThere was no significant difference in PSQI score and nocturia frequency between the AGEs‐low (n = 223) and AGEs‐high (n = 224) groups at baseline. The PSQI score and nocturia frequency increased significantly over 5 years in both groups. However, the PSQI score increased significantly in the AGEs‐high group compared with the AGEs‐low group, although there was no difference in nocturia. Background‐adjusted multivariable analysis showed that the AGE‐high was significantly associated with PSQI score worsening, but AGE‐high was not significantly associated with nocturia worsening.ConclusionsOxidative stress may be significantly associated with worsening sleep disorders, although oxidative stress may not significantly worsen nocturia frequency.
Improvement and validation of a computational model of flow in the swirling well cell culture model
Authors: Arshad Mehwish , Rowland Ethan M. , Riemer Kai , Sherwin Spencer J. , Weinberg Peter D. 
Published: October 2021

AbstractEffects of fluid dynamics on cells are often studied by growing the cells on the base of cylindrical wells or dishes that are swirled on the horizontal platform of an orbital shaker. The swirling culture medium applies a shear stress to the cells that varies in magnitude and directionality from the center to the edge of the vessel. Computational fluid dynamics methods are used to simulate the flow and hence calculate shear stresses at the base of the well. The shear characteristics at each radial location are then compared with cell behavior at the same position. Previous simulations have generally ignored effects of surface tension and wetting, and results have only occasionally been experimentally validated. We investigated whether such idealized simulations are sufficiently accurate, examining a commonly‐used swirling well configuration. The breaking wave predicted by earlier simulations was not seen, and the edge‐to‐center difference in shear magnitude (but not directionality) almost disappeared, when surface tension and wetting were included. Optical measurements of fluid height and velocity agreed well only with the computational model that incorporated surface tension and wetting. These results demonstrate the importance of including accurate fluid properties in computational models of the swirling well method.
Prediction of allergic reaction risk of Shenmai injection based on real‐world evidence coupled with UPLC–Q‐TOF‐MS
Authors: Jiang Cheng , Zhao Lisha , Xin Chuanwei , Dong Yu , Shen Jie , Xia Zhongni , Shou Dan , Li Gonghua 
Published: October 2021

AbstractThe allergic reaction (AR) of Chinese herbal injection (CHI) has become one of the most noticeable focuses of public health in China. However, it still remains a considerable controversy as to whether low‐molecular‐weight components in CHI have potential sensitization. In this study, the relationship between AR and low‐molecular‐weight component profile of Shenmai injection was explored by an interdisciplinary technology integrating real‐world evidence and ultra‐performance liquid chromatography–quadrupole time‐of‐flight mass spectroscopy (UPLC–Q‐TOF‐MS). The AR information of hospitalized patients was obtained by comprehensively analyzing real‐world evidence from January 2015 to June 2019 at two Chinese hospitals. The UPLC–Q‐TOF‐MS was exploited to systematically investigate the low‐molecular‐weight component profile with 50–1500 m/z mass range, and 3725 MS1 peaks were detected. The optimized partial least squares discriminant analysis model was established to map the influence of low‐molecular‐weight components on AR. The results of this study showed that high levels of organic acids administered intravenously might be a potential risk factor for inducing AR. By using this method, Shenmai injection with high AR risk could be recognized precisely with 100% accuracy before clinical use.
Naturalistic smartphone keyboard typing reflects processing speed and executive function
Authors: Ross Mindy K. , Demos Alexander P. , Zulueta John , Piscitello Andrea , Langenecker Scott A. , McInnis Melvin , Ajilore Olusola , Nelson Peter C. , Ryan Kelly A. , Leow Alex 
Published: October 2021

AbstractObjectiveThe increase in smartphone usage has enabled the possibility of more accessible ways to conduct neuropsychological evaluations. The objective of this study was to determine the feasibility of using smartphone typing dynamics with mood scores to supplement cognitive assessment through trail making tests.MethodsUsing a custom‐built keyboard, naturalistic keypress dynamics were unobtrusively recorded in individuals with bipolar disorder (n = 11) and nonbipolar controls (n = 8) on an Android smartphone. Keypresses were matched to digital trail making tests part B (dTMT‐B) administered daily in two periods and weekly mood assessments. Following comparison of dTMT‐Bs to the pencil‐and‐paper equivalent, longitudinal mixed‐effects models were used to analyze daily dTMT‐B performance as a function of typing and mood.ResultsComparison of the first dTMT‐B to paper TMT‐B showed adequate reliability (intraclass correlations = 0.74). In our model, we observed that participants who typed slower took longer to complete dTMT‐B (b = 0.189, p < .001). This trend was also seen in individual fluctuations in typing speed and dTMT‐B performance (b = 0.032, p = .004). Moreover, participants who were more depressed completed the dTMT‐B slower than less depressed participants (b = 0.189, p < .001). A practice effect was observed for the dTMT‐Bs.ConclusionTyping speed in combination with depression scores has the potential to infer aspects of cognition (visual attention, processing speed, and task switching) in people's natural environment to complement formal in‐person neuropsychological assessments that commonly include the trail making test.
Novel human melanoma brain metastasis models in athymic nude fox1nu mice: Site‐specific metastasis patterns reflecting their clinical origin
Authors: Svendsen Henrik A. , Meling Torstein R. , Nygaard Vigdis , Waagene Stein , Russnes Hege , Juell Siri , Rogne Siril G. , Pahnke Jens , Helseth Eirik , Fodstad Øystein , Mælandsmo Gunhild M. 
Published: October 2021

AbstractBackgroundMalignant melanomas frequently metastasize to the brain, but metastases in the cerebellum are underrepresented compared with metastases in the cerebrum.MethodsWe established animal models by injecting intracardially in athymic nude fox1nu mice two human melanoma cell lines, originating from a cerebral metastasis (HM19) and a cerebellar metastasis (HM86).ResultsUsing magnetic resonance imaging (MRI), metastases were first detected after a mean of 34.5 days. Mean survival time was 59.6 days for the mice in the HM86 group and significantly shorter (43.7 days) for HM19‐injected animals (p < 0.001). In the HM86 group, the first detectable metastasis was located in the cerebellum in 15/55 (29%) mice compared with none in the HM19 group (p < 0.001). At sacrifice, cerebellar metastases were found in 34/55 (63%) HM86‐injected mice compared with 1/53 (2%) in the HM19‐injected (p < 0.001) mice. At that time, all mice in both groups had detectable metastases in the cerebrum. Comparing macroscopic and histologic appearances of the brain metastases with their clinical counterparts, the cell line‐based tumors had kept their original morphologic characteristics.ConclusionsThe present work demonstrates that human brain‐metastatic melanoma cells injected intracardially in mice had retained inherent characteristics also in reproducing interaction with subtle microenvironmental brain tissue compartment‐specific features. The models offer new possibilities for investigating tumor‐ and host‐associated factors involved in determining tissue specificity of brain metastasis.