bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood group O attributes to prolonged PFS, OS and five-year survival in IDH-wildtype glioblastoma patients with MGMT promoter methylation
Authors: Wiewrodt Rainer , Kloss Maren , Jost-Engl Johanna , Troschel Fabian M , Troschel Benjamin O , Eich Hans Theodor , Thomas Christian , Lemcke Lars , Stummer Walter , Wiewrodt Dorothee 
Published: February 2025

Abstract

Background
Glioblastoma (GBM) remains incurable despite multimodal therapeutic approaches. Here, we assessed the relevance of ABO blood groups for progression-free (PFS), overall survival (OS), and long-term survival in a large cohort of IDH-wildtype (wt) GBM patients.

Methods
Consecutive GBM patients (2009-2020) at a large tertiary brain tumour centre were included, and clinical data were retrospectively abstracted. We dichotomised patients into those with blood group O and those with a Non-O blood group. Patient, tumour, and treatment characteristics were compared between these groups. Association with outcomes was assessed in univariable and multivariable settings via log-rank tests and Cox proportional hazards regressions, respectively.

Results
554 GBM IDH-wt had available ABO information. There were no substantial differences in patient, tumour, or treatment characteristics between group O and group Non-O. In contrast, blood group O patients showed increased PFS, OS, and five-year survivals in both univariable and multivariable analyses. Differences were strongly pronounced in patients with MGMT promoter methylated tumours receiving standardised radiochemotherapy (OS blood group O 24.6 months (95%CI 17.8–31.4) versus Non-O 17.7 months (14.1–21.3), p=0.015 log-rank analysis, hazard ratio 0.70 (95%CI 0.53-0.94)), but not apparent in MGMT promoter unmethylated tumours and in patients without (standardised) adjuvant therapy.

Conclusion
Blood group O status in conjunction with MGMT promoter methylation (including weak methylation) is an independent favourable prognostic marker in GBM IDH-wt patients receiving standardised radiochemotherapy. This finding is unprecedented, suggesting a linkage between the downregulation of a DNA repair protein and the absence of a functional blood cell surface glycosyltransferase.
66 THE POSITIVE EFFECT OF AEROBIC EXERCISE ON SOCIAL COGNITION IN ADOLESCENTS WITH SCHIZOPHRENIA
Authors: Gao Zhili , Yang Chaojie , Yang* Chaozhi 
Published: February 2025

Abstract

Background
In recent years, the social cognitive impairment of schizophrenia has become a focus of research. Social cognition refers to an individual’s ability to recognize, understand, and influence the behavior of others in social interactions, and for people with schizophrenia, impairment of this ability severely affects their social functioning and quality of life. As a special group of adolescents with schizophrenia, their social cognitive impairment is more significant. As a non-drug therapy, aerobic exercise has been proved to have a positive effect on social cognitive function in a variety of neuropsychiatric diseases. The aim of this study was to explore the potential positive effects of aerobic exercise on social cognition in adolescents with schizophrenia, and to provide evidence for clinical intervention.

Methods
A randomized controlled trial (RCT) was performed. A randomized controlled trial (RCT) was performed on 60 patients diagnosed with juvenile schizophrenia in a hospital, and the selected patients were randomly divided into an experimental group and a control group, with 30 people in each group. The experimental group received aerobic exercise training for 30 minutes five times a week for 12 weeks, while the control group only did the same amount of stretching. Before and after the experiment, facial expression recognition, eye contact, social reasoning and other indicators of social cognitive ability were evaluated in the two groups.

Results
The results of social cognitive indicators before and after comparison between the experimental group and the control group are shown in Table 1. As can be seen from Table 1, in the facial expression recognition index, the average value of pre-test and post-test in the experimental group was 50.2 and 68.5. In the index of eye contact, the pretest average was 35.6, and the posttest average was 52. In the social reasoning index, the average value of pre-test was 42.3, and the average value of post-test was 59.8.

Discussion
The experimental group showed significant improvement in facial expression recognition, eye contact and social reasoning, which indicated that aerobic exercise had a positive effect on the social cognitive ability of adolescents with schizophrenia. This study not only provides a new idea and method for non-drug treatment of adolescents with schizophrenia, but also provides strong evidence for further exploring the impact of aerobic exercise on cognitive function in patients with mental illness. Future studies can further explore the effects of different exercise types, exercise intensity and exercise time on social cognition of adolescents with schizophrenia, as well as the combined application of aerobic exercise and other therapeutic means.
Epidural Analgesia During Labour and Severe Maternal Morbidity: Population-Based Study
Authors: Kearns RJ , Kyzayeva A , Halliday LOE , Lawlor DA , Shaw M , Nelson SM 
Published: February 2025

(BMJ. 2024;385:e077190. http://dx.doi.org/10.1136/bmj-2023-077190)
The increasing incidence of severe maternal morbidity (SMM) is a worldwide health concern impacting both mothers and their children. As outlined by the CDC, SMM encompasses 21 different conditions or procedures, such as heart attacks and childbirth-related hysterectomies. In the UK, the incidence of severe maternal morbidity (SMM) almost doubled between 2009 and 2018, possibly as a result of factors like advanced maternal age, obesity, and more concurrent health conditions. SMM is seen as a signal of maternal deaths, allowing for interventions to enhance the health of mothers and babies. Epidural analgesia (EA) is commonly advised for women with an increased chance of experiencing severe maternal morbidity (SMM), such as those with more than one pregnancy, obesity, or certain underlying health conditions, because of its physiological advantages and quick pain relief in urgent situations. Limited evidence exists to support the role of EA in preventing severe maternal morbidity (SMM).
Childbirth Experiences in Women With Polycystic Ovary Syndrome: A Cohort Study
Authors: Husby AE , Simpson MR , Dalbye R , Larsen M , Vanky E , Løvvik TS 
Published: February 2025

(Acta Obstet Gynecol Scand. 2024;103(6):1092–1100. doi:10.1111/aogs.14800)
Polycystic ovary syndrome (PCOS) is a complicated disorder with 4 different types, impacting 5% to 20% of females based on diagnostic standards and the specific group being examined. It is linked with various other health conditions, such as metabolic syndrome, type 2 diabetes, insulin resistance, obesity, and cardiovascular risks, as well as psychological issues like anxiety and depression. Matters related to reproduction, like gestational diabetes, premature birth, and cesarean delivery, are frequently seen. Metformin, a drug for diabetes, is commonly utilized to enhance insulin sensitivity and has been proven to lower rates of preterm births and late miscarriages in PCOS patients, but it does not prevent gestational diabetes.
Nationwide, Couple-Based Genetic Carrier Screening
Authors: Kirk EP , Delatycki MB , Archibald AD , Tutty E , Caruana J , Halliday JL , Lewis S , McClaren BJ , Newson AJ , Dive L , Best S , Long JC , Braithwaite J , Downes MJ , Scuffham PA , Massie J , Barlow-Stewart K , Kulkarni A , Ruscigno A , Kanga-Parabia A , Rodrigues B , Bennetts BH , Ebzery C , Hunt C , Cliffe CC , Lee C , Azmanov D , King EA , Madelli EO , Zhang F , Ho G , Danos I , Liebelt J , Fletcher J , Kennedy J , Beilby J , Emery JD , McGaughran J , Marum JE , Scarff K , Fisk K , Harrison K , Boggs K , Giameos L , Fitzgerald L , Thomas L , Burnett L , Freeman L , Harris M , Berbic M , Davis MR , Cifuentes Ochoa M , Wallis M , Wall M , Chow MTM , Ferrie MM , Pachter N , Quayum N , Lang N , Pandy PK , Casella R , Allcock RJN , Ong R , Edwards S , Sundercombe S , Jelenich S , Righetti S , Lunke S , Kaur S , Stock-Myer S , Eggers S , Walker SP , Theodorou T , Catchpool T , Clinch T , Roscioli T , Hardy T , Zhu Y , Fehlberg Z , Boughtwood TF , Laing NG ,   Mackenzie’s Mission Investigators
Published: February 2025

(N Engl J Med. 2024;391:1877–1889. doi:10.1056/NEJMoa2314768)
The Australian Reproductive Genetic Carrier Screening Project (Mackenzie’s Mission) aimed to assess the feasibility and outcomes of offering reproductive genetic carrier screening (RGCS) to more than 10,000 reproductive couples, focusing on the identification of pathogenic variants in genes associated with severe, childhood-onset conditions. The study tested these couples (free of charge) for pathogenic variants in at least 1281 genes, linked to about 750 autosomal recessive or X-linked conditions. The primary objective was to evaluate the uptake of screening, participant attitudes, and psychosocial outcomes, as well as to explore the impact of genetic information on reproductive decision-making.
Neurodevelopmental Outcomes After Late Preterm Antenatal Corticosteroids: The ALPS Follow-Up Study
Authors: Gyamfi-Bannerman C , Clifton RG , Tita ATN , Blackwell SC , Longo M , de Voest JA , O’Shea TM , Bousleiman SZ , Ortiz F , Rouse DJ , Metz TD , Saade GR , Rood KM , Heyborne KD , Thorp JM , Swamy GK , Grobman WA , Gibson KS , El-Sayed YY , Macones GA ,   for the Eunice Kennedy Shriver Maternal-Fetal Medicine Units Network
Published: February 2025

(JAMA. 2024;331(19):1629–1637. doi:10.1001/jama.2024.4303)
The Antenatal Late Preterm Steroids (ALPS) trial, a significant study in US clinical practice, demonstrated that administering antenatal betamethasone to women delivering between 34 and 36 weeks 6 days of gestation could reduce short-term neonatal respiratory morbidity. However, the trial also revealed a higher incidence of neonatal hypoglycemia linked to the betamethasone treatment. Given these findings, a subsequent follow-up study was designed to assess whether this late-preterm steroid administration had any impact on long-term neurodevelopmental outcomes in children.
Variation in Hospital Neuraxial Labor Analgesia Rates in California
Authors: Parameshwar P , Guo N , Bentley J , Main E , Singer SJ , Peden CJ , Morris T , Ansari J , Butwick AJ 
Published: February 2025

(Anesthesiology. 2024; 140:1098–110. doi:10.1097/ALN.0000000000004961)
Neuraxial analgesia (NA) includes epidural, spinal, and combined spinal-epidural analgesia, and is recommended to be available in all maternity hospitals in the United States. There are significant maternal benefits to this effective method of pain reduction during labor and delivery and though this recommendation was instituted by the American College of Obstetricians and Gynecologists there is little data about the prevalence of NA and about factors that can account for variation in its use or accessibility. This study was designed to assess hospital variation in the prevalence of NA using maternal discharge and vital statistics data in California.
Decoding Labour Epidural Analgesia and Autism: Navigating the Abyss Between Statistical Significance, Biological Plausibility, and Clinical Relevance
Authors: Devroe S , Bleeser T , Lucas N 
Published: February 2025

(Eur J Anaesthesiol. 2024;41(4):257–259. doi:10.1097/EJA.0000000000001965)
Widespread use of labor epidural analgesia (LEA) in developed countries as the leading pain management technique during pregnancy without many adverse perinatal events should suggest its efficacy and safety. However, various researchers and some in the general public have begun to question the lasting effects in children born in the setting of maternal LEA use. One such neurodevelopmental disorder being examined is autism spectrum disorder (ASD). A 2020 study claimed a 37% risk increase for ASD diagnoses in children whose mother used LEA during the birthing process. Although this and other similar publications have received widespread attention, in this editorial, authors caution mothers and providers to carefully consider the complexity of the neurodevelopmental disorder etiology.
Ropivacaine Perineal Infiltration for Postpartum Pain Management in Episiotomy Repair: A Double-Blind, Randomized, Placebo-Controlled Trial
Authors: Cardaillac C , Planche L , Dorion A , Ploteau S , Thubert T , Lefizelier E , Winer N , Ducarme G 
Published: February 2025

(BJOG. 2024;131(7):899–907. doi:10.1111/1471-0528.17266)
Episiotomy, a surgical technique that widens the vaginal opening to facilitate delivery, continues to be frequently performed despite global suggestions to reduce its frequency, with prevalence varying from 8% to 59%. Postpartum perineal pain affects a large majority of women, with 97% experiencing it in the first 24 hours and 61% to 76% experiencing it from days 7 to 10. This discomfort may last for months and is associated with postpartum depression and sexual dysfunction, affecting 50% of women a year after having an episiotomy or a third-degree tear.
“Detect Anemia Preoperatively”: A Scoping Review of Recommendations
Authors: Schneider Katja , Sauer Diana , Wolf Lorenz , Willms Arnulf G. 
Published: February 2025

Background:
Preoperative anemia significantly impacts patient outcomes, prompting increasing global implementation of patient blood management (PBM) measures. Timely diagnosis and differentiation of preoperative anemia are crucial components of PBM to maximize its effectiveness. Despite this, comprehensive implementation remains inconsistent. This scoping review aims to give an overview of recommendations regarding preoperative anemia management to detect gaps in knowledge and emerging ideas.

Methods:
A scoping review, adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, investigated preoperative anemia detection, focusing on patient population, timing, extent, and process of investigations. PubMed and ScienceDirect were searched for English and German articles published in the last 5 years, supplemented by manual selection. Pediatric and obstetric recommendations were excluded. Results were synthesized based on key questions.

Results:
Four hundred sixty-five articles were screened, and 80 met the inclusion criteria, including 25 clinical practice guidelines. Most (n = 62) suggested “detect and correct” anemia without further specification. The rest advised conducting investigations early, ideally up to 30 days before major procedures with expected blood loss >500 mL. Recommended tests include blood counts, various iron parameters, folic acid/vitamin B12, inflammation markers, and renal, hepatic, and thyroid function tests. Ten articles described detailed algorithms. Other key recommendations included using reticulocyte hemoglobin, point-of-care Hb measurements, and automated laboratory algorithms. The underlying quality of scientific evidence is heterogeneous.

Conclusions:
International recommendations on the detection of preoperative anemia are heterogeneous and often generic. Automated algorithms could make a significant contribution to practicability. While practice-oriented guidelines, especially by surgical societies, could promote standardized and efficient implementation, further research is needed to improve the quality of underlying scientific evidence.
Observations of Communication Practices Between Men Who Have Sex With Men With HIV and HIV Specialist Nurses During Routine Consultations Regarding Sexual Health Counseling in the Netherlands: A Qualitative Study
Authors: de Munnik Suzanne , den Daas Chantal , Ammerlaan Heidi Sophia Maria , Kok Gerjo , de Wit John , Vervoort Sigrid Cornelia Johanna Maria 
Published: February 2025

Abstract
This study investigated how HIV specialist nurses communicate with men who have sex with men with HIV during routine consultations with a focus on sexual health counseling in the Netherlands. In this multicenter observational study, 16 video-recorded consultations from four HIV treatment centers were analyzed. Verbatim transcriptions were analyzed to assess the topics discussed, the duration of consultations, time spent on sexual health counseling, and specific issues covered. Communication skills were evaluated through a predefined framework. The findings indicated inconsistent coverage of sexual health, varied topics, and a lack of structure. Various communication skills and techniques were applied inconsistently. Given these findings, we recommend implementing communication strategies during routine consultations to improve the quality of sexual health counseling, especially for men who have sex with men with HIV. This is essential to improve the quality of sexual health counseling for persons with HIV, especially men who have sex with men.
Respiratory dysfunction in patients that recovered from coronavirus disease 2019 pneumonia: A six-month follow-up study
Authors: Meng Xianglin , Luo Peiyao , Wang Jianpeng , Wu Haolan , Sun Chongyang , Kang Kai , Yu Kaijiang , Zhao Mingyan 
Published: February 2025

Background:
This study investigates the clinical features and pulmonary functions of coronavirus disease 2019 (COVID-19) pneumonia survivors at 3 or 6 months after diagnosis in the Heilongjiang Province, China.

Methods:
Forty-six patients with COVID-19 pneumonia diagnosed starting from February 2020 were enrolled in this study for follow-up in August 2020. These patients were categorized into three groups: Group A (n = 24) and Group B (n = 11), who were diagnosed with moderate or severe pneumonia and followed up at three months after diagnosis, and Group C (n = 11), who were diagnosed with severe pneumonia and were followed up at 6 months after diagnosis. Pulmonary functions, arterial blood gas analysis, and clinical features, including chest high-resolution computed tomography (HRCT), blood tests, and health-related quality of life during hospitalization and at follow-up visits, were collected and analyzed.

Results:
Abnormal PO2 (A-a) was more prevalent in severe cases (Groups B and C) than in moderate cases (Group A). Respiratory dysfunction was common in our patients. HRCT showed that the abnormal computed tomography (CT) scores of severe cases (Groups B and C) were significantly higher than those of moderate cases (Group A). During the follow-up period, lung abnormalities gradually resolved in the first three months (Groups A and B); however, further resolution was not significant from 3-6 months (Groups B and C).

Conclusion:
Although pulmonary interstitial changes due to COVID-19 pneumonia gradually reverse over time, respiratory dysfunction is common and appears to persist for at least up to 6 months in patients who have recovered from COVID-19 pneumonia.
Qualifying Cochlear Implant Candidates—Does it Matter How Patients Are Qualified?
Authors: Lee David S. , Herzog Jacques A. , Walia Amit , Smetak Miriam R. , Pavelchek Cole , Durakovic Nedim , Wick Cameron C. , Ortmann Amanda J. , Buchman Craig A. , Shew Matthew A. 
Published: February 2025

Objective
Evaluate variable qualification criteria for cochlear implant (CI) recipients and 12-month speech perception outcomes.

Study Design
Retrospective cohort study.

Setting
HERMES national database and nonoverlapping single-institution CI database.

Patients
A total of 2,124 adult unilateral CI recipients categorized by qualifying status: AzBio in quiet (n = 1,239), +10 dB SNR (but not in quiet; n = 519), +5 dB SNR (but not in quiet or +10 dB SNR; n = 366); CNC ≤40% (n = 1,037), CNC 41% to 50% (n = 31), and CNC 51% to 60% (n = 20).

Interventions
CI.

Main Outcome Measures
Pre- and 12-month postoperative speech perception performance. Clinically significant improvement was defined as ≥15% gain.

Results
Quiet qualifiers experienced improvement in all listening conditions, whereas +10 dB SNR and +5 dB SNR qualifiers only improved in their qualifying condition and implanted ear CNC. When stratified by expanded Medicare criteria (binaural AzBio ≤60% correct), patients that qualified in quiet experienced improvements regardless of qualifying threshold or background noise. However, those that qualified in noise and AzBio ≤60% experienced mixed results in quiet and limited gain in background noise. When ≤60% criteria was applied to CNC of the worse ear, ≤40% qualifiers experienced large improvements in all tested conditions, but those who qualified by 41% to 50% or 51% to 60% only demonstrated modest improvements in AzBio sentence testing.

Conclusions
Quiet qualifiers improved in all testing conditions, while those qualifying in noise improved in their qualifying condition. Patients who qualified by expanded Medicare criteria (≤60%) showed improvement when qualifying with AzBio in quiet, but should be used with caution when qualifying patients in background noise or CNC due to more limited gains in performance.
Characterization of the Expression and Role of Striatin-Interacting Protein 2 in Mouse Cochlea
Authors: Li Siyu , Qiu Yue , Li Ao , Lu Jie , Ji Xinya , Hao Wenli , Cheng Cheng , Gao Xia 
Published: February 2025

Hypothesis
In this study, we aimed to examine the cochlear expression pattern and function of Striatin-interacting protein 2 (STRIP2) by using animal models.

Background
Sensorineural hearing loss often results from genetic defects in hair cell (HC) development and function. STRIP2 is a part of the striatin-interacting phosphatase and kinase (STRIPAK) complex, which plays important regulatory roles in cell fate determination, proliferation, cytoskeletal organization, and cell morphology. A recent study revealed Strip2 as the candidate gene that regulates positive selection in HC lineages. However, its role in the inner ear has not been identified.

Methods

Strip2 knockout mouse model was used to examine the cochlear expression pattern and function of STRIP2. Auditory brainstem response test was used to evaluate the hearing function of mice. Immunostaining and scanning electron microscope were used to study hair cells, synapses, and stereocilia of cochlea.

Results
Immunostaining showed that cytoplasmic STRIP2 expression in hair cells increased from postnatal day (P) 3 to P14. Despite having normal hearing thresholds, hair cell numbers, and stereocilia morphology until P90, the deletion of Strip2 resulted in a mild reduction in ribbon synapse density, suggesting a late onset of cochlear synaptic defects.

Conclusion
Our results revealed that STRIP2 was abundantly expressed in hair cells; however, the hearing function of Strip2
−/− mice was comparable to that of control mice until P90, and a mild decrease in ribbon synapse number was detected at P60 and P90. Further studies on STRIP2 and its associated complexes will provide new insights into the pathways involved in inner ear development and function.