bluuebunny/crossref_metadata_2025_split huggingface dataset:
Point-of-care platform integrated with deep-learning, convolutional neural network algorithms effectively evaluates canine and feline peripheral blood smears
Authors: Morissette Eric , Penn Cory D. , Hall Sedlak Ruth A. , Rhodes Austin J. , Tippetts Dan S. , Loenser Mike , Goldstein Richard 
Published: December 2024

Abstract

OBJECTIVE
To perform a diagnostic assessment of a point-of-care veterinary multiuse platform integrated with a model comprised of deep-learning, convolutional neural network algorithms for evaluating canine/feline peripheral blood smears compared to board-certified clinical pathologists (CPs).

METHODS
This study had a blinded, randomized, incomplete block design, and results were compared between CPs and algorithms. Blood smears from convenience samples from veterinary diagnostic reference laboratories from October to December 2021 were used. Study phase A comprised 2 parts: (1) object class identifier algorithm (leukocytes, platelets, polychromatophils, and nucleated erythrocytes) versus CP within the same field of view (FOV); and (2) monolayer detection algorithm plus object class identifier algorithm versus CPs with different FOVs. Study phase B comprised algorithms versus CP for platelet clump identification. Study phase C comprised algorithms versus CP for polychromatophil identification. Metrics including sensitivity, specificity, and agreement were used.

RESULTS
The sample size was 59 dogs and 60 cats in phase A, 92 dogs and 69 cats in phase B, and 47 dogs and 12 cats in phase C. For study phase A, part 1, the 5-part leukocyte differential count agreement was 96.6% for canine and 91.7% for feline blood smears, and for part 2, the agreement for estimated total leukocyte, platelet, polychromatophil, and nucleated erythrocyte counts ranged from 70% to 95% across species. In study phase B, the algorithm had 90% sensitivity and 88% specificity. The algorithm for polychromatophils had 100% agreement with CP results in phase C.

CONCLUSIONS
This platform achieved results comparable to those of CPs. Results are meant to complement automated CBC results.

CLINICAL RELEVANCE
Veterinarians may add this assessment as part of their standard in-clinic hematology analysis for patients.
Reimagining Barbie. A Feminist Analysis of Iconography and Consumerism in the Age of Gender Reevaluation
Authors: Bobaru Nicolae 
Published: December 2024

Abstract
This paper critically analyses the motion picture Barbie (2023) within the context of gender discourse and consumer culture, exploring its dual role as a feminist artefact and a commodity. Drawing on seminal feminist theories, including Betty Friedan’s critique of domesticity and Naomi Wolf’s exploration of beauty as a social construct, alongside other scholarly works, including Robin Gerber’s historical account of Barbie’s creation, J. Lenore Wright’s exploration of body archetypes, Mary F. Rogers’ critique of Barbie culture, Juliette Peers’ fashion doll evolution, and Kim Toffoletti’s posthuman feminist perspective, the study interrogates the film’s portrayal of feminist ideals against its commercial backdrop. By examining Barbie’s impact on gender identity, societal norms, and consumer behaviour, the paper contributes to the nuanced debate on the interplay between feminist representation and media commodification, offering insights into the complexities of engaging with feminist themes in a consumer-driven landscape.
Examining “Salami slicing” publications as a side-effect of research performance evaluation: An empirical study
Authors: D’Angelo Ciriaco Andrea 
Published: December 2024

ABSTRACT

Purpose
This study investigates whether publication-centric incentive systems, introduced through the National Scientific Accreditation (ASN: Abilitazione Scientifica Nazionale) for professorships in Italy in 2012, contribute to adopting “salami publishing” strategies among Italian academics.

Design/methodology/approach
A longitudinal bibliometric analysis was conducted on the publication records of over 25,000 Italian science professors to examine changes in publication output and the originality of their work following the implementation of the ASN.

Findings
The analysis revealed a significant increase in publication output after the ASN’s introduction, along with a concurrent decline in the originality of publications. However, no evidence was found linking these trends to increased salami slicing practices among the observed researchers.

Research limitations
Given the size of our observation field, we propose an innovative indirect approach based on the degree of originality of publications’ bibliographies. We know that bibliographic coupling cannot capture salami publications per se, but only topically-related records. On the other hand, controlling for the author’s specialization level in the period, we believe that a higher level of bibliographic coupling in his scientific output can signal a change in his strategy of disseminating the results of his research. The relatively low R-squared values in our models (0.3-0.4) reflect the complexity of the phenomenon under investigation, revealing the presence of unmeasured factors influencing the outcomes, and future research should explore additional variables or alternative models that might account for a greater proportion of the variability. Despite this limitation, the significant predictors identified in our analysis provide valuable insights into the key factors driving the observed outcomes.

Practical implications
The results of the study support those who argue that quantitative research assessment frameworks have had very positive effects and should not be dismissed, contrary to the claims of those evoking the occurrence of side effects that do not appear in the empirical analyses.

Originality/value
This study provides empirical evidence on the impact of the ASN on publication behaviors in a huge micro-level dataset, contributing to the broader discourse on the effects of quantitative research assessments on academic publishing practices.
First molecular characterisation of Sarcocystis miescheriana in a pig carcass condemned during routine meat inspection in Poland
Authors: Korpysa-Dzirba Weronika , Rubiola Selene , Bilska-Zając Ewa , Różycki Mirosław , Chiesa Francesco , Bełcik Aneta , Samorek-Pieróg Małgorzata , Kubacki Jakub , Łukomska Anna , Karamon Jacek , Sroka Jacek , Cencek Tomasz 
Published: December 2024

Abstract

Introduction
This article presents the fourth detection of macroscopic cystic lesions due to sarcocystosis in domestic pigs during routine meat inspection worldwide, and the first molecular detection of Sarcocystis miescheriana in a domestic pig in Poland. Pigs can become intermediate hosts for S. miescheriana by accidental ingestion of oocysts or sporocysts present in food or water contaminated by the faeces of canids (definitive hosts).

Material and Methods
The affected swine showed no clinical symptoms such as weight loss, dermatitis or dyspnoea suggesting sarcocystosis. The presence of grossly visible cyst-like lesions was noticed by veterinary inspectors during post-mortem meat inspection of pig carcasses at a slaughterhouse located in central Poland. Ten rice-grain-shaped white lesions were isolated from the muscle tissue for molecular analysis, and four other macroscopic cyst-like lesions were also isolated for histopathological and microscopy analysis. The molecular characterisation included amplification and sequencing of the cytochrome C oxidase subunit 1 mitochondrial gene.

Results
The cyst-like structures were whitish, calcified, 1 cm long and 3 mm wide. The presence of S. miescheriana DNA was confirmed in all ten grossly visible cyst-like lesions.

Conclusion
This study shows that Sarcocystis spp. may be present in swine muscle tissue and cause lesions leading to carcass discard. Further analyses are needed to fully recognise the prevalence and impact of Sarcocystis spp. on animal and human health, especially taking into account the possible presence of the zoonotic S. suihominis.
Motivational Climate, Satisfaction, and Intrinsic Motivation in University Students After the Application of a Gamified Intervention Using Traditional Sports Games
Authors: Gea-García Gemma María , Martínez Eduardo López 
Published: December 2024

Abstract
Gamified learning environments are widely used within the educational context in the subject of Physical Education. The aim of this study was to analyze the perception of the motivational climate, satisfaction, and intrinsic motivation of university students in practical classes according to gender and the type of methodology used. A total of 76 university students aged 20.58±1.69 participated in twelve two-hour practical sessions. The sessions were developed through traditional sport games, which were divided according to the type of methodology used: traditional (TRA, n=6) and gamified (GAM, n=6). Afterwards, to detect the differences in mean scores obtained for each of the methodologies used, the following tests, if needed, were performed: a non-parametric Friedman’s test with a post-hoc Wilcoxon test for pair-wise comparisons, or a two-factor repeated measures with a post-hoc Bonferroni test. Additionally, a Receiver Operating Characteristic curve analysis was performed to determine the cut-off point of the variables studied as a function of the classification of the study participants according to gender. The results showed differences in the perception of motivational climate according to gender in the traditional instructional approach. More specifically, the score for the dimension task climate was higher (M=4.21±0.58) than that recorded for the female students (M=4.57±0.45). In addition, for intrinsic motivation, the male students showed differences between both methodologies, with a higher score in the gamified program in the dimensions competence (M=3.63±0.51) effort-importance (M=3.57±0.55) and tension-pressure (M=2.92±0.85). Finally, there were significant differences between the two methodologies for satisfaction scores with the classes by gender. In each and every dimension that showed significant differences, the scores obtained by the female students were higher than those recorded for the male group in both methodologies. The application of a gamified intervention emerges as a powerful tool that could increase the motivation and satisfaction of students, favoring the teaching-learning process.
Descartes : l’invention du moi moderne ?
Authors: Kambouchner Denis 
Published: December 2024

Je souhaiterais revenir sur une représentation qui nous est à tous familière : celle d’après laquelle, au vrai départ de la modernité, l’on trouverait l’œuvre de Descartes, et plus précisément, dans cette œuvre, la constitution, l’activité et la mise en scène d’un moi. Ce mot lui-même, « la modernité », désignerait en somme un nouvel âge de la subjectivité, un âge de la subjectivité proprement dite, et cette subjectivité serait, par excellence, la subjectivité cartésienne.
International legal aspects of the Black Sea Grain Initiative
Authors: Gordeev Artem 
Published: December 2024

The subject of the study is the international agreements concluded within the framework of the Black Sea Grain Initiative as one of the humanitarian vectors of cooperation between states in the field of agriculture and food security under restrictive measures, as well as other international legal and non-legal acts. The object of the study is international interstate relations developing in the process of cooperation in the field of agriculture, food security, humanitarian cooperation, as well as interstate cooperation in the field of the use of the high seas and territorial waters. The purpose of the study was to analyze the international legal characteristics of the agreements concluded within the framework of the Black Sea Grain Initiative (BSGI), including determining the main prerequisites for their conclusion and identifying their significance for international law. In the course of the research, such methods of scientific cognition were used as: dialectical, method of analysis and synthesis, deduction and induction, statistical, system-structural, historical, formal legal, comparative legal, method of legal linguistics. The novelty of the study is determined by the fact that there is no research in the domestic doctrine devoted to the international legal characteristics of BSGI. As a result of the study, it was revealed that the main factors contributing to the BSGI were the negative impact of unilateral restrictive measures against the Russian Federation on the one hand and the armed conflict in Ukraine on the other hand. At the same time, unilateral restrictive measures against the Russian Federation affecting the domestic agricultural sector, by their legal nature, contradict the basic principles of international law. The international agreements within the framework of the BSGI had a humanitarian purpose and were mainly aimed at stabilizing global food security. The Memorandum and the Initiative concluded within the framework of the BSGI have different legal status and are not formally interrelated: The Initiative concluded by the Russian Federation, Turkey and Ukraine is an international treaty, whereas the Memorandum between the UN Secretariat and the Russian Federation is a non-legal agreement. The main importance of the BSGI for international law is as follows: states are able to cooperate with each other in order to ensure food security even in conditions of geopolitical tension; Russia is ready to faithfully fulfill its international legal obligations; it is necessary to further develop the UN mediation function in resolving issues related to ensuring global food security.
The Clinical Diagnosis and Treatment of an Anterior Calcaneal Process Fracture Overlooked on Imaging: A Case Study
Authors: Gilbert-Hogan, Teri 
Published: December 2024

BACKGROUND: Anterior calcaneal process fractures are often overlooked on radiographs. Given a similar clinical presentation, these fractures are frequently misdiagnosed as lateral ankle sprains. CASE DESCRIPTION: A 43-year-old male was referred to physical therapy following an inversion ankle injury. Sites of interest identified on initial radiography were asymptomatic, including an os trigonum and possible dorsal talar avulsion fracture. Screening with the Ottawa ankle rules was negative. His clinical presentation was similar to an inversion ankle sprain with concordant swelling and pain. OUTCOME: Subsequent ankle imaging was completed following a lack of expected clinical progression, revealing a subtle calcaneal fracture overlooked on initial imaging. The patient was referred to orthopedics and managed in a boot with partial weight-bearing. He was released to full weight-bearing 6 weeks later with resolution of pain and gradual recovery of normalized range of motion and strength. DISCUSSION: Improving proficiency of interpreting radiograph images as physical therapists, application of the four-eyes principle when reading images, and awareness of potential fractures with negative Ottawa ankle rules screening are beneficial to early and accurate diagnosis and treatment of foot fractures. JOSPT Cases 2025;5(1):12-17. Epub 20 December 2024. doi:10.2519/josptcases.2024.0086
N-acetyltransferase 10 regulates UNC-51-like kinase 1 to reduce tubular cell injury and kidney stone formation
Authors: Wang Le , Huang Jinjing , Song Lei , Ke Ben 
Published: December 2024

Objective:
Among the most common chronic kidney diseases, kidney stones are second only to hypertension. Kidney stones pose a public health threat due to their increased incidence, high recurrence rate, and heavy economic burden. In this work, we investigated the potential mechanism of N-acetyltransferase 10 (NAT10) in oxidative stress and pyroptosis of renal tubular epithelial cells (RTECs).

Material and Methods:
A kidney-stone cell model was simulated using calcium oxalate monohydrate (COM) in vitro. Western blot analysis of NAT10 expression and N4-acetylcytidine RNA immunoprecipitation verified the regulatory efficacy of NAT10 in Unc-51 like autophagy activating kinase 1 (ULK1) ac4C modification. The luciferase reporter gene assay further verified the interaction between NAT10 and ULK1. A kidney stone model was established using BALB/c mice injected with glyoxylic acid.

Results:
COM can dose-dependently suppressed the cell viability and superoxide dismutase activity of HK-2 cells and promoted the release of lactate dehydrogenase and malondialdehyde levels (P < 0.05). COM also promoted apoptosis in HK-2 cells, upregulated the protein levels of caspase-1 and gasdermin D-N, and simultaneously enhanced the HK-2 cell secretion of interleukin-1b (IL-1b) and IL-18 (P < 0.05). The overexpression of NAT10 in HK-2 cells reversed the aforementioned effects, and that of NAT10 upregulated the messenger RNA (mRNA) levels of ULK1 and increased ac4C modification (P < 0.01). Furthermore, only the luciferase activity of the wild-type ULK1 containing NAT10 binding sites was enhanced with the upregulation of NAT10 (P < 0.001). Actinomycin D treatment showed that NAT10 overexpression extended the half-life of ULK1 mRNA (P < 0.01). Silencing of ULK1 neutralized the effects of NAT10 overexpression on COM-induced cell injury (P < 0.05). In addition, the increased expression of NAT10 inhibited crystal deposition, oxidative stress, and apoptosis in vivo (P < 0.05).

Conclusion:
This study confirmed that NAT10 inhibits RTECs oxidative stress and cell pyrodeath through the enhanced ac4C modification of ULK1 and impedes kidney stone progression.
Efficacy of radiosurgery with and without angioembolization: A subgroup analysis of effectiveness in ruptured versus unruptured arteriovenous malformations – An updated systematic review and meta-analysis
Authors: Khan Hamza , Sangah Abdul Basit , Nasir Roua , Khan Saad Akhtar , Shaikh Shazia Saleem , Ahmed Ikhlas , Abbasi Mohad Kamran , Ahmed Asma , Siddiqui Dua , Hussain Syeda Ayesha , Akhunzada Naveed Zaman , Godfrey Oswin 
Published: December 2024

Background:
Congenital arterial defects such as cerebral arteriovenous malformations (AVMs) increase brain bleeding risk. Conservative therapy, microsurgical removal, percutaneous embolization, stereotactic radiosurgery (SRS), or a combination may treat this serious disease. This study compares angioembolization with SRS to SRS alone in ruptured or unruptured brain ateriovenous malformations (BAVM) patients.

Methods:
We followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations for this study. Until September 2023, PubMed/Medline, Cochrane, and Clinicaltrials.gov were searched for literature. English-language studies comparing SRS alone to embolization with SRS on ruptured or non-ruptured AVMs that could not be operated on were considered. The Newcastle–Ottawa Scale assessed research study quality.

Results:
Results included 46 studies with a total of 7077 participants. There was a greater obliteration rate in the SRS-only group (60.4%) than in the embolization plus SRS group (49.73%). Particularly in the SRS-only group, ruptured AVMs showed a noticeably greater obliteration rate than unruptured AVMs (P = 0.002). However, no notable differences were found in hemorrhagic events or radiation-induced changes between the two groups; however, the SRS-only group had a slightly greater, yet not statistically significant, mortality rate.

Conclusion:
Our data showed that ruptured brain AVMs had a much greater obliteration rate than unruptured ones, mostly due to SRS alone, without embolization. The aggregated data showed no significant changes, whereas SRS alone decreased radiation-induced alterations and hemorrhagic rates but with increased mortality. SRS alone may have a higher risk-to-reward ratio for nidus obliteration in ruptured brain AVM patients, so it should be used without embolization, although more research is needed to determine the effects of immediate and late complications.
Bilateral hypothalamotomy plus dominant amygdalotomy with Gamma Knife radiosurgery. A non-invasive alternative when everything has failed in the management of aggressive behavior disorder
Authors: Romero Oscar I. Molina , Diez-Palma Juan Carlos , Fonnegra-Caballero Andrés , Segura-Hernández Andrés , Matinez-Alvarez Roberto , Yamhure Edgar , Camargo Julian Felipe , Fonnegra-Pardo Julio Roberto 
Published: December 2024

Background:
Impulsive aggression is the core symptom of intermittent explosive disorder, which can be a feature of several psychiatric disorders. There is a subset of individuals who do not respond adequately to medical treatment; they are treatment refractory. The objective of this report is to describe a case of a patient with a background of schizophrenia and concomitant refractory aggressiveness disorder, treated with two-stage bilateral hypothalamotomy and unilateral amygdalotomy with Gamma Knife radiosurgery (GKR).

Case Description:
A 36-year-old male presented with a background of paranoid schizophrenia. Episodes of self- and hetero-aggressiveness were present at the initial diagnosis. High dosages of psychotropic medication were taken, and 70 sessions of electroconvulsive therapy were performed; however, no adequate response was obtained. Bilateral hypothalamotomy plus left amygdalotomy through GKR was performed. After 25 months of follow-up, a marked decrease in the frequency, degree, severity of aggressiveness and the requirement for psychotropic medications was observed.

Conclusion:
Hypothalamotomy plus amygdalotomy with Gamma Knife may be an effective ablative technique for the management of refractory aggressive disorder in patients with mental illness.
A comparative meta-analysis of mini-transverse versus longitudinal techniques in the treatment of carpal tunnel syndrome
Authors: Aleid Abdulsalam Mohammed , Alanazi Sultan Nawaf , Aljabr Abdulmajeed Abdulaziz , Almalki Sami Fadhel , AlAidarous Hasan Ali Abdullah , Alzahrani Abdulwahab Ahmed , Aleid Zainab Mohammed , Alghamdi Yousef Khalaf A. , Aldanyowi Saud Nayef 
Published: December 2024

Background:
Carpal tunnel syndrome (CTS) is a common nerve entrapment condition, and there is ongoing debate regarding the superiority of traditional open versus minimally invasive carpal tunnel surgery.

Methods:
This meta-analysis reviewed six studies involving 478 patients to compare recovery and functional outcomes between the traditional longitudinal technique and the minimally invasive mini-transverse technique. The primary outcomes included the functional status scale (FSS), symptoms severity scale (SSS), pain scores, time to return to work, duration of operation, and incidence of complications.

Results:
The mini-transverse technique was associated with lower FSS and SSS scores compared to the longitudinal technique, with mean differences (MD) of −0.32 (95% confidence level [CI]: −0.52, −0.12, P = 0.002) and −0.43 (95%CI: −0.6, −0.25, P < 0.00001), respectively. Pain scores were also lower with the mini-transverse technique (MD) of −0.5 (95%:CI: −0.71, −0.3, P < 0.00001). The mini-transverse group had a statistically significant shorter time to return to work (MD) of −8.34 (95%CI: −13.55, −3.13, P = 0.002). No significant differences were found in the duration of surgery (MD) of −6.96 (95%CI: −16.66, 2.74, P = 0.16) or incidence of complications (MD) of 0.46 (95%CI: 0.15, 1.4, P = 0.17).

Conclusion:
The mini-transverse approach for CTS resulted in better outcomes, including less pain, faster recovery, and improved hand function. There was no significant difference in surgery time or complications compared to the traditional technique, suggesting it may be the preferable option.