bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Scientific Evaluation Standard of Medical Articles for Public: a Delphi Study
Authors: Xu Xin , li Qiyu , Qi Fei , Yu Wen-li , Zhang Ying , Li Yang , Sun Xin-ying , Wu Yi-bo 
Published: October 2021

Abstract
Background At present, the quality of articles in the field of medical popularization in China cannot be guaranteed, so it is necessary for experts engaged in scientific popularization to estabish a consensus on scientfic evaluation criteria to improve it.Objective This article aims to improve this by reaching a consensus about the scientificalness of medical articles for public through Delphi method among experts.Method The article type is research article.On the basis of AGREE II method, a set of criteria for evaluating the scientificalness of popular science articles was established, and then three rounds of Delphi expert consultation were conducted in order to achieve the final consensus.Results A total of 31 people took part in all three rounds of research, while 4 people lost their visits. Most metric reaches consensus (agreement>80%) in the final round while there remains argument concerning the “Total number of evidence selected”, “Whether a case is regarded as general situation”, “If new research evidence exists”, “The qualification of the platform for the publication of popular science articles” and “Conflict of interest”.Conclusion This study established a unified scientific evaluation standard for medical popular science articles. The study is of great significance to the establishment of operable scientific evaluation standard of popular science articles. Future research should focus on the diversity in specific aspect.
A Survey on Telemedicine in a Sleep Clinic During the COVID-19 Pandemic: Benefits and Barriers!
Authors: Tondo Pasquale , Scioscia Giulia , Hoxhallari Anela , Sabato Roberto , Barbaro Maria Pia Foschino , Lacedonia Donato 
Published: October 2021

Abstract
Background. Several restrictive measures have been taken to prevent the spread of SARS-CoV-2, restricting the access to outpatient follow-ups, increasing waiting lists in chronic diseases, such as obstructive sleep apnea (OSA). The aim of study is to evaluate the benefits and the barriers of telemedicine in a sleep clinic.Methods. Subjects with diagnosis of OSA treated with continuous positive airway pressure (CPAP) were surveyed with a phone-questionnaire to assess the difficulties and knowledge of remote monitoring systems (telemedicine). Furthermore, the participants were divided into two groups according to the favor of telemedicine visits, POSITIVE (in-favor) and NEGATIVE (in favor of in-person visits) and compared with statistical methods.Results. Fifty-three OSA participants (85% men), aged 67,9±7,5 yrs and BMI 36,0±8,0 kg/m 2 were enrolled in the study. The comparison of POSITIVE (24/53) and NEGATIVE (29/53) groups showed some significant differences: knowledge of telemedicine (p=0,001), high education level (p=0,01) and high computer skills (p=0,001) are the main factors influencing the acceptance of telemedicine. In addition, 57% of overall participants seem more likely to conduct a remote visit in the future.Conclusions. Although telemedicine is a useful tool, a majority of patients in our study preferred in-person visits. However, they are willing to conduct telemedicine visits in the future, so our findings suggest that improving patient computer skills and updating technological systems in order to facilitate patients' access may be important strategies to boost acceptance of telemedicine.
Paclitaxel Combined with Ticagrelor Inhibits B16F10 and Lewis Lung Carcinoma Cell Metastasis
Authors: Meng Xingjun , Cao Zhihui , Liu Renfeng , Zheng Kai , Ding Shuai , Gu Yuefan , Chen Yonghua , Lv Jun , Li Ping , Zhou Li , Wang Wenbo , Ji Shiliang , He Hui , Yang Hui 
Published: October 2021

Abstract
It is widely accepted that tumor metastasis is the dominant factor leading to cancer-related death. Tumor metastasis is mediated by cell invasion, blood circulation and lymphatic circulation. Paclitaxel, as a common anti-tumor drug and a mitotic inhibitor, promotes microtubule assembly and inhibits microtubule depolymerization. In addition, ticagrelor, an anti-platelet drug, is used to treat acute coronary syndrome. An increasing numbers of studies have reported that platelets can facilitate tumor metastasis. Therefore, inhibiting the effects of platelets can serve as a novel therapeutic strategy for cancer. To explore the effect of anti-tumor and anti-platelet drugs on tumor progression, the murine melanoma cell line, B16F10, and Lewis Lung carcinoma (LLC) cells were treated with paclitaxel and/or ticagrelor. Interestingly, the results demonstrated that paclitaxel and ticagrelor could not only suppress the proliferation, migration and invasion of B16F10 and LLC cells, but they could also prevent tumor metastasis to the lungs. Furthermore, the inhibitory effect of paclitaxel and ticagrelor was more apparent when both drugs were used in combination. Collectively, the current study demonstrated that the combination of paclitaxel and ticagrelor could be considered as a potential anti-tumor therapy approach.
Low Expectation of Employment Benefit Associated with Motivation in Clinical Nursing: Baseline Findings from an Interventional Study Among Nursing Students in Tanzania
Authors: Herman Patricia , Kibusi Stephen 
Published: October 2021

Abstract
Background

Nursing professional is an art of calling which requires unconditional devotion in caring for those who are in need. Motivation to join the nursing profession is a question that warrants further study. However, there is a dramatic increase in population who join the profession as an opportunity for stable employment and benefit. Intrinsic and extrinsic key elements of motivation are to be examined to determine the art of joining the nursing profession. This study intended to assess baseline motivation in clinical learning from a quasi-experimental study that aimed to design and test the effect of an interactive web-based clinical practice monitoring system toward improving clinical meta-competencies among nursing students in Tanzania
Methods

This is the analysis of baseline data from an interactive web-based clinical practice monitoring system of 589 randomly selected undergraduate nursing students in Tanzania. Baseline data were collected using a self-guided questionnaire on the Academic motivation Scale adopted from previous studies. Both descriptive and inferential statistics were adopted using Statistical Product for Service Solution version 23. The confidence interval was set at 95% with a significance level of 5%.
Results

Findings show that 65% of the nursing students were male while 79.6% of them were younger than 24 years. Baseline finding of motivation in clinical learning revealed that 80.6% of nursing students were not motivated in clinical learning of which 19.4% of motivated nursing students, 5.3% were intrinsically motivated against 14.1% were extrinsically motivated in clinical learning. Extrinsic factors such as opportunity to travel around the world, generous salary and employment benefits, and perceiving nursing as a secure profession were significantly associated with low motivation in clinical learning (p<0.05)
Conclusion

The problem of low motivation in clinical learning among nursing students seems to persist among undergraduate nursing students in Tanzania. Many enrolled nursing students are forced to join the profession by extrinsic factors than intrinsic ones. This study recommends innovative clinical nursing education pedagogical in enhancing motivation in clinical learning among nursing students in Tanzania.
A Maturity-Onset Diabetes of The Young (MODY) 5 Young Woman With HNF1B Heterozygosity Missing Based On 17q12 Recurrent Deletion Syndrome
Authors: Cheng Ying , Zhong Da-Peng , Ren Li , Yang Hang , Tian Chen-Fu 
Published: October 2021

Abstract
Maturity-onset diabetes of the young type 5 (MODY5) is a rare subtype of MODYs. It caused by mutations of the hepatocyte nuclear factor 1 homeobox b gene (HNF1B). A 21-year-old young woman was admitted to our hospital for severe malnutrition and gastrointestinal symptoms. At age 20, she was diagnosed with type 2 diabetes mellitus and was administered with oral antidiabetic drugs. Soon afterwards, the patient discontinued the medication on her own accord, and then went to the hospital again due to diabetic ketoacidosis. After insulin treatment, diabetic ketoacidosis was cured and blood glucose was controlled satisfactorily. But intractable nausea, vomiting and persistent weight loss was stubborn. Further examination revealed that the patient had hypokalemia and hard rectification hypomagnesemia. Genetic testing revealed about 1.85Mb heterozygous fragment deletion on chromosome 17 and deletion of exons 1-9 of HNF1B heterozygosity missing was approved. Finally, the patient was diagnosed MODY 5 with HNF1B heterozygosity missing based on 17q12 recurrent deletion syndrome.
Key words: Maturity-onset diabetes of the young 5 (MODY5), Hepatocyte nuclear factor 1 homeobox b gene (HNF1B), 17q12 Recurrent deletion syndrome
Rice (Oryza sativa L.) breeding for novel black short grain associated with yield, cooking quality, high nutrition and antioxidant potential derived from indica black rice x japonica white rice
Authors: Malumpong Chanate , Narumol Possawat , Saichompoo Uthomphon , Tongyos Peeranut , Nanta Aekchupong , Tippunya Patompong , Chompoo Jamnian , Itthisoponkul Teerarat , Vanavichit Apichart , Cheabu Sulaiman 
Published: October 2021

Abstract
The combination of the trend of Japanese food consumption with the health benefits of black rice is in high demand for rice consumers in Thailand. For this challenge, incorporation of desirable traits from temperate japonica white rice, Akitakomachi and tropical indica black rice, Riceberry was performed by pedigree selection with maker assisted selection (MAS) and these desirable traits have been presented in breeding progenies. The three candidate lines showed highly favorable agronomic characteristics and a high grain yield, with short grains and good cooking quality, similar to japonica rice, in a tropical climate. In addition, these lines showed black coloration of the pericarp, indicating high nutritional value (including Fe, Zn, Vit B6, Vit E and folate levels) and phytochemical, antioxidant and antidiabetic activities, similar to those of the Riceberry parent. In terms of the sensory testing of unpolished rice, two breeding lines (69-1-1 and 72-4-3) showed higher scores than their parents. However, only 69-1-1 was identified as japonica type according to its genetic background. Therefore, this breeding program, involving the crossing of a temperate japonica white rice with a tropical indica black rice, can create novel black short grain rice variety adapted to a tropical environment, similar to japonica-type rice.
Triangular Fixation to Prevent Proximal Screw Pullout in Adult Spinal Deformity Surgery: A Technical Note
Authors: Tanaka Masato , Mehta Rahul , Yamauchi Taro , Arataki Shinya , Uotani Koji , Fujiwara Yoshihiro , Shinohara Kensuke , Yamane Kentaro 
Published: October 2021

Abstract
Background
Adult spinal deformity (ASD) is caused by spinal malalignment and results in severe low back pain, neurological dysfunction, and severe deformity. Proximal screw back-out represents a difficult problem in minimally invasive ASD surgery. We describe a novel technique to prevent screw pullout in ASD.
Methods
A 71-year-old woman was referred to our hospital with severe low back pain and gait difficulty. Her daily life had been affected by severe lower back pain for more than 6 months. Standing radiograms indicated severe kyphoscoliosis. Two-stage minimally invasive corrective T10-to-pelvis fixation was performed.
Results
The first surgery was an L1–S1 C-arm-free oblique lumbar interbody fusion, with an operation time of 3 h 57 min and an estimated blood loss of 240 mL. After 1 week, the second percutaneous pedicle screw (PPS) fixation was performed and proximal screws were inserted under a transdiscal approach (T11) and with a lower angulation trajectory (T10) to enhance pullout strength. For this second surgery, operation time was 3 h 33 min, and estimated blood loss was 320 mL. No postoperative complications or neurological compromise was reported. In terms of clinical outcomes, Oswestry Disability Index improved from 56–24%, and visual analog scale score for lower back pain improved from 62 mm to 24 mm at the 1-year follow-up.
Conclusions
Minimally invasive circumferential surgery with triangular fixation is effective for preventing proximal screw back-out and surgical invasiveness. With this new technique, surgeons and operating room staff can avoid the risk of adverse events due to intraoperative radiation exposure.
Determining Factors for the Creation of Innovation-based Ventures
Authors: Escorcia Adalberto , Ramos-Ruiz Jose , Zuluaga-Ortiz Rohemi , Delahoz-Dominguez Enrique 
Published: October 2021

Abstract
This research aims to create a model that provides a more complete view of the behavior of entrepreneurs, to investigate the influence of Social Capital, Entrepreneurial Self-Efficacy and Per-son-Entrepreneurship Fit in the transition of nascent entrepreneurs towards the venture creation. For the development of this research, a sample of 500 entrepreneurs located in Colombia who are in the process of creating a company was taken. The research methodology is hypothetical-deductive with a cross-sectional multiple causal correlation design with explanatory scope and is divided into three stages: First, an exploratory analysis of the data relating to the study variables is carried out. Second, a Principal Component Analysis is carried out. Finally, the third stage is the modelling using the Partial Least Squares - Path Modelling methodology. Among the most relevant findings, it is found that Social Capital is significant in explaining Person-Entrepreneurship Fit. In turn, Social Capital and Person-Entrepreneurship Fit are significant in explaining Entrepreneurial Self-Efficacy. Finally, the construct of Venture Creation is only significantly explained by Per-son-Entrepreneurship Fit. Consequently, it can be concluded that the influence of social and psychological variables within the business cycle are significant, and models and strategies must consider these elements in order to design tools that support the optimal development of start-ups within the business cycle, so that they consolidate as stable ventures.
Word of caution: negative impact of mouthwashes on folded Platelet-Rich Fibrin (F- PRF) membrane viability
Authors: Csönge Lajos , Bozsik Ágnes , Bagi Zoltán Tóth , Gyuris Róbert , Csönge Dóra Kinga , Kovács Tünde , Kónya János 
Published: October 2021

Abstract
Backround: The number of clinical application of different platelet-rich fibrin (PRF) membranes has increased in regenerative medicine including regenerative dentistry. Intact platelets, leukocytes and stem cells of PRF play a crucial role in the local bone augmentation releasing cytokines and growth factors. An integral part of the postsurgical management is the application of mouthwashes especially chlorhexidine-digluconate, which is recommended in order to prevent postoperative infections. In some cases there is possibility that there is contact between the mouthwash and PRF membrane. The impact of mouthwashes on cell viability of folded F-PRF was tested. Methods: 3 mouthwash brands were tested: Chorsodyl, Listerine 6 in 1 and Elmex Sensitive Plus using MTT viability assay after 30 seconds treatment and 72 hours treatment (twice daily for 30 seconds). The membrane samples were incubated in cell culture conditions. Results: 30 seconds of mouthwash treatment diminished the fresh F-PRF viability significantly by 15-21% depending on the agent. After 72 hours of treatment the viability loss was ~50%. Conclusion: The decreased number of platelets and other blood cells can not launch optimal bone morphogenesis. The MTT assay is cheap, reliable and simple method to assess the platelet and cellular viability and potential regenerative capacity of F-PRF membrane, or any platelet-rich product. The isolation of the PRF membrane from oral liquids and/or application of less aggressive mouthwashes is recommended for at least 5-7 days after PRF surgery.
Assessment of Human-Induced Effects in the Sultan Marshes (Ramsar Protection) Kayseri (Turkey)
Authors: Aydin-Kandemir Fulya , Demir Aynur 
Published: October 2021

Abstract
Sultan Marshes is one of Turkey's Ramsar wetlands and has faced significant threats in recent years. Although the water was brought from other basins for restoration, observed temporal human-induced impacts and the current drought have damaged the wetland qualities of the Marshes. In this study, the temporal change of the Marshes and the human-induced effects are analyzed. Spatiotemporal surface water area (1984-2020) and whole land use changes (1990-2018) are evaluated with the temporal change of the Human Development, Global Terrestrial Human Footprint, and Ecological Footprint Indexes. The land use changes since 1990 reveal how the wetland has lost its functions. Especially between 1990-2000, the water area largely shifted into the sandy and swampy areas. In the swampy areas between 1990-2000, natural pasture formation was also observed in 2000. In addition, it is found that mining fields were constructed in the region between 1990-2000, albeit relatively small. According to the study, the most remarkable change occurred in the 1990-2000 period, considering the entire study timeline (1990-2018). In this period, there was also a transformation into irrigated agricultural lands around the national park. Moreover, there was a transformation from orchards and pasture areas to irrigated agricultural areas. When the changes in the wetland are evaluated with the human footprint data for 1993 and 2009, it was found that human impact was more substantial, especially in 1993 compared to 2009. This is in line with the continuous increase in HDI values between 1990 (0.54) and 2018 (0.81). Besides, the ecological footprint has increased since 1983. After 1983, the biocapacity in the region has steadily decreased to negative values.
Clinical Practice of Umbilical Cord Blood Stem Cells in Transplantation and Regenerative Medicine - Prodigious Promise for Imminent Times
Authors: Ray Suman Kumar , Mukherjee Sukhes 
Published: October 2021

:The umbilical cord blood is usually disposed of as an unwanted material after parturition; however, today, it is viewed as a regenerative medication so as to create the organ tissues. This cord blood gathered from the umbilical cord is made up of mesenchymal stem cells, hematopoietic stem cells, and multipotent non-hematopoietic stem cells having many therapeutic effects as these stem cells are utilized to treat malignancies, hematological ailments, inborn metabolic problem, and immune deficiencies. Presently, numerous clinical applications for human umbilical cord blood inferred stem cells, as stem cell treatment initiate new research. These cells are showing such a boon to stem cell treatment; it is nevertheless characteristic that the prospect of conservation of umbilical cord blood is gaining impetus. Current research works have demonstrated that about 80 diseases, including cancer, can be treated or relieved utilizing umbilical cord blood stem cells, and every year, many transplants have been effectively done around the world. However, in terms of factors, including patient selection, cell preparation, dosing, and delivery process, the treatment procedure for therapy with minimally manipulated stem cells can be patented. It is also worth thinking about how this patent could affect cord blood banks. Meanwhile, the utilization of cord blood cells is controversial and adult-derived cells may not be as successful, so numerous clinicians have begun working with stem cells that are acquired from umbilical cord blood. This review epitomizes a change in outlook from what has been completed with umbilical cord blood cell research and cord blood banking on the grounds that cord blood cells do not require much in the method of handling for cryopreservation or for transplantation in regenerative medicine.
Profiling of Essential Mineral Content, Heavy Metals, and Bacterial Contaminants in Conventional and Organic Eggs Available in the Hypermarkets of the Eastern Province of Saudi Arabia
Authors: Dahlawi Saad , Berekaa Mahmoud , Salama Khaled , Labib Ossama , Saifullah  , Asghar Waqas , Khalid Nauman 
Published: October 2021

Background:
Eggs are commonly regarded as one of the best sources of various macro
and micronutrients, in particular, high biological value (BV) proteins and both saturated and unsaturated
fatty acids. Apart from proteins, eggs are excellent sources of various high health value
lipid components, carotenoids, minerals, and both water and lipid-soluble vitamins. However, the
nutrient-rich nature of this ‘superfood’ also makes them susceptible to microbial contamination
from various sources, such as fecal matter, drinking water for layer chicken, and the surrounding
environment. Moreover, drinking water and chicken feed are also sources of heavy metal contamination.
The presence of both factors poses serious health concerns for consumers.

Objective:
The main aim of this research was to proximate heavy metals and bacterial contaminants
in nine different brands of brown organic and conventional white eggs available in the hypermarkets
of the Eastern Province of Saudi Arabia.

Methods:
An Inductively Coupled Plasma-Optical Emission Spectrometer (ICP-OES) was used to
determine the concentration of metals with high sensitivity. Standard plate count was followed by
enrichment of bacterial contaminants in a double-strength nutrient broth medium for microbiological
assessment.

Results:
The results indicated that Pb, Cd, Al, and As were present in high concentrations in all egg
brands of both types (organic and conventional). The estimated daily intake (EDI) values for Ca,
Fe, Mn, and Mg were within the range of WHO-recommended thresholds, and these essential minerals
were present in adequate amounts in all egg brands. The two major groups predominating the
microbial loads were the family Enterobacteriaceae and Pseudomonas sp.

Conclusion:
The presence of heavy metals, such as Al, As, Pb, and Cd, in nearly all the brands in
amounts that exceeded the established ADI and EDI thresholds was considerably concerning. In
particular, the elevated levels of Cd and Pb in group 1 and group 2A probable human carcinogens,
respectively, demands that local regulatory authorities investigate the sources of heavy metal contamination
and alleviate this considerable risk to human health. Furthermore, this study could be a
benchmark for establishing food safety and hygiene standards for local egg production, storage,
handling, and transport in Saudi Arabia.