bluuebunny/crossref_metadata_2025_split huggingface dataset:
À travers forêts et bétons du texte : les dystopies scopiques de Marie Darrieussecq et de Karoline Georges
Authors: Perron Laurence 
Published: May 2021

Dans cet article, je m’intéresse aux romans dystopiques de Marie Darrieussecq (Notre vie dans les forêts, 2017) et de Karoline Georges (Sous béton, 2011), deux productions récentes qui témoignent d’un rapport à l’écran qui dépasse la simple thématisation. Je soutiens notamment que la question de la médiation écranique va jusqu’à régir l’écriture dans son élaboration stylistique et poétique. Je convoque à cet effet les distinctions entre immediacy et hypermediacy (Bolter et Grusin, 2000) afin de nommer efficacement les phénomènes médiatiques que génère la culture de l’écran, pour montrer que ces derniers trouvent réponse au sein d’une narration aussi brisée et altérée que les écrans (ainsi que l’oeil qui les regarde) mise en scène par les deux autrices.
Knowledge, Attitudes and Practices of the Population in an Urban District Facing COVID-19 in Kisangani, DRC
Authors: Yakusu Issa , Baelongadi Francis , Bumba Lobela , Bonyoma Osinga , Eugene Basandja Longemba , Kapunzu Muyobela , Bassandja Ossinga , Tshilumba Kayembe 
Published: May 2021

Objective: To determine the levels of knowledge, attitudes and practices towards Covid-19 among residents of the Plateau Boyoma neighborhood.
Methods: A questionnaire was designed and a cross- sectional survey was carried out among 214 households in the Plateau Boyoma district between September 27 and October 27, 2020. Participants were questioned on knowledge, attitudes and practices towards the COVID-19. The data was analyzed by SPSS.
Results: The majority of respondents were males aged 39 to 45 years. Most of the participants had higher education (68.7%). The main sources of information on COVID-19 were radio and television. The majority of respondents had a positive attitude towards complying with government infection control measures, 43.9% said they frequently wash their hands with soap and water, cover their mouth and their skin, respectively nose when coughing or sneezing. However, household concern about COVID-19 is very great. In this study, the surveys had a high level of knowledge about COVID-19 and adapted attitudes towards this disease. However, community health campaigns are necessary to have optimistic attitudes and practice appropriate intervention measures without misconceptions.
Constraints and Suggestions Perceived by the Pulse Farmers of Nayagarh District of Odisha
Authors: Prusty Ajay Kumar , Mohapatra Bibhuti Prasad 
Published: May 2021

Aims: To study the constraints faced by pulse farmers in adopting improved pulse production practices and their suggestions to overcome the constraints.
Study Design: Ex post facto survey research design with proportionate random sampling techniques.
Place and Duration of the Study: Nayagarh district of Odisha during 2019-2020.
Methodology: A total of 256 respondents covering 8 villages from 4 blocks of Nayagarh district were selected as sample respondents. The data were collected by personal interview using a well structured questionnaire. The data were tabulated and analyzed by using Garrett’s ranking technique for the study of constraints and suggestions.
Results: The findings of the study indicate that major constraints for adopting pulse production technologies were improper knowledge about recommended doses of pesticides and fertilizers (59.57 percent), lack of knowledge about improved agricultural technologies time to time (59.2 percent), lack of technology and training to create local storage structures (66.55 percent) and inadequate training of farmers (55.49 percent). Major suggestions of pulse farmers to overcome these constraints were improved varieties should be provided (68.04 percent), more number of FLDs should be given in village to enable other farmers to take advantage (66.85 percent) and training be imparted to implement new technologies (66.85 percent).
Conclusion: Research on modification of agronomic practices and their different components for excelling production under changing climatic scenario need to be strengthened with more training for the farmers to enrich their knowledge and skill about pulse production.
CT‐less electron radiotherapy simulation and planning with a consumer 3D camera
Authors: Skinner Lawrie , Knopp Rick , Wang Yi‐Chun , Dubrowski Piotr , Bush Karl K. , Limmer Alyssa , Trakul Nicholas , Million Lynn , Marquez Carol M. , Yu Amy S. 
Published: May 2021

AbstractPurposeElectron radiation therapy dose distributions are affected by irregular body surface contours. This study investigates the feasibility of three‐dimensional (3D) cameras to substitute for the treatment planning computerized tomography (CT) scan by capturing the body surfaces to be treated for accurate electron beam dosimetry.MethodsDosimetry was compared for six electron beam treatments to the nose, toe, eye, and scalp using full CT scan, CT scan with Hounsfield Unit (HU) overridden to water (mimic 3D camera cases), and flat‐phantom techniques. Radiation dose was prescribed to a depth on the central axis per physician’s order, and the monitor units (MUs) were calculated. The 3D camera spatial accuracy was evaluated by comparing the 3D surface of a head phantom captured by a 3D camera and that generated with the CT scan in the treatment planning system. A clinical case is presented, and MUs were calculated using the 3D camera body contour with HU overridden to water.ResultsAcross six cases the average change in MUs between the full CT and the 3Dwater (CT scan with HU overridden to water) calculations was 1.3% with a standard deviation of 1.0%. The corresponding hotspots had a mean difference of 0.4% and a standard deviation of 1.9%. The 3D camera captured surface of a head phantom was found to have a 0.59 mm standard deviation from the surface derived from the CT scan. In‐vivo dose measurements (213 ± 8 cGy) agreed with the 3D‐camera planned dose of 209 ± 6 cGy, compared to 192 ± 6 cGy for the flat‐phantom calculation (same MUs).ConclusionsElectron beam dosimetry is affected by irregular body surfaces. 3D cameras can capture irregular body contours which allow accurate dosimetry of electron beam treatment as an alternative to costly CT scans with no extra exposure to radiation. Tools and workflow for clinical implementation are provided.
Ghosts in the nursery in exile—Supporting parenting in exile during the COVID‐19 pandemic
Authors: Schestag Lena , Mehner‐Gentner Janina , Stein Lea , Rossi Hildegard , Fischmann Tamara , Leuzinger‐Bohleber Marianne , Fritzemeyer Korinna 
Published: May 2021

AbstractThe early prevention project “Strong together!” supports refugee parents and their young children (0–4 years) in Berlin, Germany. It aims to mitigate the transmission of trauma to the generation born in exile. For refugee families who have only recently arrived in Germany, the COVID‐19 pandemic poses a particularly great challenge. Not only are they confronted with numerous challenges in respect to re‐building their lives in Germany after fleeing war and persecution, but are also vulnerable to conscious and unconscious anxieties, fantasies, and conflicts evoked by the pandemic and the threat it poses to their lives. This was observed in the context of the mother–child groups of “Strong together!”. Many expressed great insecurity, heightened levels of anxiety, re‐experiencing of traumatic scenes, and over‐strictly self‐isolating themselves and their children, even attraction to fundamentalist ideologies. In this paper, some of the empirical and clinical findings of “Strong together!” are summarized and reflected on within a framework of psychoanalytic trauma theory.
The COVID‐19 pandemic and individual and collective defences
Authors: Nicolò Anna Maria 
Published: May 2021

AbstractAt the start of March, 2020, during the Coronavirus pandemic, the Italian Psychoanalytical Society (SPI) volunteers organized an emergency helpline. This consisted of a limited series of consultations by telephone or online, with four free sessions which would not lead to a course of psychotherapy. All the operators carrying out this work gathered regularly in peer‐supervision groups where they compared their work and fulfilled a holding function for each other. The reasons for the requests varied from the reappearance of a previous psychiatric situation, to the sense of loneliness, anxiety, panic, feeling of persecution, somatizations, and hypochondriacal experiences, and on another level the dysregulation of the familial environment, marital difficulties, and parenting problems. Because of the intensity of the trauma, alongside the commonest defenses, other defenses have been activated, such as externalization, exporting, and shifting into the other of a psychic suffering that cannot be worked through. Emotional withdrawal, the avoidance of contact in the state of heightened alertness are other characteristics of these situations. The suffering that derives from these traumas will then be at the center of a crucible formed by the intrapsychic, the interpersonal, and the transpersonal. Today psychoanalysis is encountering enormous cultural and social changes, and this recent experiment of ours has shown us the importance of working to give a response in moments of crisis since needs that are not worked through today risk being transformed into serious psychopathological problems tomorrow.
Comparative genomic signatures in young and old Chinese patients with colorectal cancer
Authors: Wang Fei , Cheng Huanqing , Zhang Xiao , Shan Lina , Bai Bingjun , Chen Kangke , lou Feng , Cao Shanbo , Wang Huina , Dai Sheng 
Published: May 2021

AbstractBackgroundOccurrence at a young age is known to be associated with unique clinical features in colorectal cancer (CRC). However, the genomic differences between young and old patients with CRC are not well elucidated and, to the best of our knowledge, have never been investigated in a Chinese population.MethodsTumor tissue samples from 29 young (age ≤50 years) and 46 old (age >50 years) patients with CRC were collected. Targeted sequencing of 808 cancer‐related genes was conducted to characterize the genomic landscape for Chinese CRC.ResultsOverall, mutational profiles exhibited notable differences between the two groups. In particular, APC and PIK3CA mutations were more frequently observed in old patients (p = 0.009 and p = 0.012, respectively), while SMAD4 mutations tended to occur in young patients (p = 0.054). Mutation loci distributions of KRAS in the young cohort differed from those in the old cohort, and a higher frequency of KRAS codon 12 mutations was potentially associated with a young age (p = 0.076). The frequencies of clinically actionable alterations were analyzed by defined age categories, which unveiled a distinctive targeted genomic profile in the young group. Furthermore, among patients with mismatch repair‐proficient (pMMR) CRC, tumor mutation burden (TMB) was positively correlated with age (Pearson's r = 0.306, p = 0.011), and genomic alterations associated with high TMB in young patients differentiated from those in old patients.ConclusionsThese findings revealed different molecular characterization between young and old Chinese patients with CRC, which may provide novel insights for the personalized treatment of CRC.
Sarcopenia index as a predictor of clinical outcomes in older patients undergoing transcatheter aortic valve replacement
Authors: Romeo Francisco José , Chiabrando Juan Guido , Seropian Ignacio Miguel , Raleigh Juan Valle , de Chazal Horacio Medina , Garmendia Cristian Maximiliano , Smietniansky Maximiliano , Cal Mariela , Agatiello Carla Romina , Berrocal Daniel Horacio 
Published: May 2021

AbstractBackgroundSarcopenia is a prevalent condition in elderly patients and has been associated with adverse outcomes following transcatheter aortic valve replacement (TAVR). The present study aimed to determine the predictive value of serum creatinine‐cystatin C ratio, that is, “Sarcopenia Index” (SI) as a surrogate marker of sarcopenia, and investigate its association with clinical outcomes after TAVR.MethodsWe conducted a retrospective observational study of patients undergoing TAVR between January, 2016 and December, 2018 at Hospital Italiano de Buenos Aires, Argentina. Patients were excluded if <65‐years old, presented previous surgical aortic valve replacement, severe chronic kidney disease, or hemodialysis requirement. The SI was obtained at baseline before TAVR. All‐cause mortality and/or readmissions for congestive heart failure (CHF) were defined as the primary endpoint.ResultsIn total 100 patients met inclusion criteria for the purpose of the study. Sarcopenia Index was significantly correlated with Timed Up and Go (r = −0.272, p = .010) and Gait Speed (r = −0.278, p = .005). During follow‐up, 5/100 patients died within 30 days and a total of 10/100 patients died at 1‐year follow‐up. Moreover, survival curves were significantly worse (Log‐rank test = p = .02) and CHF readmissions were more prevalent in the lowest SI tertile (Log‐rank test = p = .01). In multivariate Cox regression analysis, we identified low SI (cutoff ≤66) as an independent predictor of long‐term adverse outcomes (HR = 4.01, 95% CI = 1.31–12.27, p = .015) at 1‐year follow‐up.ConclusionSarcopenia Index, surrogate for the degree of skeletal muscle mass (SMM), could be used as a predictor of adverse outcomes in patients undergoing TAVR.
Composite Search of Active Particles in Three‐dimensional Space Based on Non‐directional Cues
Authors: Kromer Justus A. , Auconi Andrea , Friedrich Benjamin M. 
Published: May 2021

AbstractWe theoretically address minimal search strategies of self‐propelled particles towards hidden targets in three‐dimensional space. The particles can sense if targets are close, e. g., by detecting released signaling molecules, but they cannot deduce directional cues. We investigate composite search strategies, where particles switch between extensive outer search and intensive inner search; inner search is started when proximity of a target is detected and ends when a certain inner search time has elapsed. In the simplest strategy, active particles move ballistically during outer search, and transiently reduce their directional persistence during inner search. In a second, adaptive strategy, particles exploit a dynamic scattering effect by reducing directional persistence only outside a well‐defined target zone. These two search strategies require only minimal information processing capabilities, yet increase target encounter rates substantially. The optimal inner search time scales as power‐law with exponent −2/3 with target density, reflecting a trade‐off between exploration and exploitation.
The effects of ARID1A mutations on colorectal cancer and associations with PD‐L1 expression by stromal cells
Authors: Kamori Tomohiro , Oki Eiji , Shimada Yoshifumi , Hu Qingjiang , Hisamatsu Yuichi , Ando Koji , Shimokawa Mototsugu , Wakai Toshifumi , Oda Yoshinao , Mori Masaki 
Published: May 2021

AbstractBackgroundARID1A is a component of the SWI/SNF complex, which controls the accessibility of proteins to DNA. ARID1A mutations are frequently observed in colorectal cancers (CRCs) and have been reported to be associated with high mutational burden and tumor PD‐L1 expression in vitro.AimTo clarify the role of ARID1A mutation in CRC.Method and resultsWe used next generation sequencing (NGS) and immunohistochemistry on clinically obtained samples. A total of 201 CRC tissues from Niigata University and Niigata Center Hospital were processed by NGS using the CANCERPLEX panel. Immunohistochemistry for ARID1A, PD‐L1, MLH1, and MSH2 was performed on 66 propensity‐matched (33 microsatellite instability‐high [MSI‐H] and 33 microsatellite‐stable [MSS]) cases among 499 cases from Kyushu University. TCGA data were downloaded from cBioPortal. NGS showed significantly more mutations in ARID1A mutated CRCs (p = 0.01), and the trend was stronger for right‐sided CRCs than left‐sided. TCGA data confirmed these findings (p < 0.01). BRAF V600E and ATM mutations were also found at higher frequencies. Immunohistochemistry showed that 30% of MSI‐H CRCs had ARID1A loss, while this was true in only 6% of MSS CRCs. In both MSI‐H and MSS, PD‐L1 expression by stromal cells was enhanced in the ARID1A‐mutant groups (90% vs 39% in MSI‐H, 100% vs 26% in MSS).ConclusionWe found a higher mutational burden in ARID1A‐mutant CRCs, and IHC study showed that ARID1A loss was correlated with high PD‐L1 expression in stromal cells regardless of MSI status. These data support the idea that mutant ARID1A is a potential biomarker for CRCs.
Intracranial complete response for non‐small‐cell lung cancer patient with negative PD‐L1 expression of the lung using nivolumab
Authors: Kitadai Rui , Zenke Yoshitaka , Hishima Tsunekazu , Hosomi Yukio 
Published: May 2021

AbstractBackgroundNivolumab has shown promising results against non‐small‐cell lung cancer (NSCLC). However, its efficacy to treat central nervous system (CNS) metastases, specifically among programmed cell death 1 ligand 1 (PD‐L1)‐negative patients, remains unclear.CaseA 66‐year‐old woman was diagnosed with adenocarcinoma stage II and underwent a left lower lobectomy. The histopathological evaluation revealed stage IVA with pleural dissemination. The patient did not harbor an epidermal growth factor receptor (EGFR) mutation or anaplastic lymphoma kinase (ALK) rearrangement, and PD‐L1 expression of the surgical specimen using 22C3 assay was 0%. Single brain metastasis was detected, and carboplatin and nab‐paclitaxel were administered. After three cycles, asymptomatic multiple brain metastases were identified, and the patient was treated with nivolumab as second‐line chemotherapy. Six months later, MRI revealed an intracranial complete response (CR). Nivolumab was discontinued after 23 cycles due to immune‐related adverse events (irAEs) of grade 2 rash. However, its effects were sustained for 13 months after discontinuation. We were unable to evaluate the PD‐L1 expression of brain metastases, which may show heterogeneity.ConclusionThis case demonstrates that nivolumab effectively treated a patient with negative PD‐L1 expression of the lung harboring CNS metastases.
Melanoma-derived extracellular vesicles skew neutrophils into a pro-tumor phenotype
Authors: Guimarães-Bastos Daniel , Frony Ana Clara , Barja-Fidalgo Christina , Moraes João Alfredo 
Published: May 2021

AbstractEvidence shows that tumor cells abundantly produce and release extracellular vesicles (EVs) that can interact with stromal cells and modulate their functions. In the tumor neighborhood, neutrophils can assume both antitumor and pro-tumor phenotypes, known as TAN-N1 and TAN-N2, respectively. Nevertheless, the contribution of tumor-derived EVs to the modulation of TAN phenotypes is still poorly understood. The effects of EVs produced by a metastatic human melanoma cell line (MV3) on the differentiation and functional changes in human neutrophils were investigated. Treatment with MV3-derived EVs induced neutrophil chemotaxis through a signaling pathway involving the CXCR2/PI3K-Akt axis, prolonged neutrophil life span, promoted formation of neutrophil extracellular traps with poor elastase activity, and increased reactive oxygen species production. In contrast, EVs also increased the expression of TAN-N2 molecular markers (such as ARG1, CXCR4, and VEGF) in neutrophils. They also impaired oxide nitric and peroxynitrite production and diminished cytotoxic activity against melanoma cells, inducing neutrophils into a pro-tumor profile. Remarkably, EV-stimulated neutrophils did not exhibit phagocytic activity. These data suggested that melanoma-derived EVs could activate neutrophils, allowing their migration toward the tumor microenvironment, and driving these cells to a pro-tumor/N2 polarization, thus contributing to tumor progression.
Recurrent hepatocellular carcinoma presenting as thoracic lymphadenopathy
Authors: Sidhu Calvin , Yagnik Lokesh 
Published: May 2021

AbstractMetastatic hepatocellular carcinoma (HCC) can involve the lung parenchyma. However, predominant thoracic lymphadenopathy involvement is less described and there are multiple alternative malignant and non‐malignant causes of a similar appearance. Accurate tissue diagnosis is important to determine appropriate management and prognostication. Here, we report two cases of metastatic HCC recurrence causing large thoracic lymphadenopathy, diagnosed adequately and safely by linear endobronchial ultrasound (EBUS) transbronchial needle aspiration.
Conversion from cilostazol to OPC‐13015 linked to mitigation of cognitive impairment
Authors: Saito Satoshi , Shinmyozu Kaori , Kawakami Daisuke , Yamauchi Miho , Ikeda Shuhei , Hattori Yorito , Yamamoto Rintaro , Hayakawa Naoki , Ihara Masafumi 
Published: May 2021

AbstractIntroductionCilostazol may be a novel therapeutic agent for Alzheimer's disease. Its metabolite, OPC‐13015, has a stronger inhibitory effect on type 3 phosphodiesterase than cilostazol.MethodsWe prospectively enrolled patients with mild cognitive impairment to whom cilostazol was newly prescribed. Patients underwent the Montreal Cognitive Assessment (MoCA) twice, at a 6‐month interval. Plasma cilostazol, OPC‐13015, OPC‐13213, and OPC‐13217 concentrations were determined using liquid chromatography‐tandem mass spectrometry.ResultsMoCA score changes from baseline to the 6‐month visit were positively correlated with ratios of OPC‐13015 to cilostazol and total metabolites (n = 19, P = .005). Patients with higher ratios of OPC‐13015 (≥0.18, median value; n = 10) had significantly higher MoCA scores (P = .036) than patients with lower ratios (the ratio <0.18, n = 9). The absolute value of OPC‐13015 concentration in blood was also higher in patients with preserved cognitive function (P = .033).DiscussionBlood OPC‐13015 levels may be a predictive biomarker of cilostazol treatment for Alzheimer's disease.
Severe uterine haemorrhage requiring a blood transfusion in a dog with ovarian remnant syndrome and secondary pyometra
Authors: Burchette Hannah M. , Moyle Rachel B. 
Published: May 2021

AbstractAn 18‐month‐old female German Shepherd dog, previously reported to be spayed, presented to a referral clinic with a history of progressive haemorrhagic vulvar discharge resulting in clinical anaemia. An abdominal ultrasound showed an enlarged uterus and a retained right ovary; vaginoscopy revealed no obvious haemorrhage from the vagina or cervix, so the dog underwent exploratory laparotomy for ovariectomy and hysterectomy. Prior to surgery, the dog received a 15 ml/kg packed red blood cell transfusion and post‐operatively was given fresh frozen plasma due to significant blood loss into the uterus. Histopathology was consistent with cystic endometrial hyperplasia, suppurative metritis and pyometra. A uterine culture grew Escherichia coli. The dog ultimately made a full recovery.
Female song in the Cyprus Wheatear Oenanthe cypriaca
Authors: Patchett Robert , Kirschel Alexander N. G. , Robins King Joanna , Styles Patrick , Cresswell Will 
Published: May 2021

AbstractFemale song is widespread across bird species yet rarely reported. Here, we report the first observations and description of female song in the Cyprus Wheatear Oenanthe cypriaca and compare it to male song through the breeding season. Twenty-five percent of colour-ringed females were observed singing at least once, predominantly in April, compared to 71% of males that continued singing through the breeding period. We suggest that female song may have multiple functions in this species, but it may be especially important in territorial defence and mate acquisition.