bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coagulation Factor V (F5) is an Estrogen-Responsive Gene in Breast Cancer Cells
Authors: Andresen Marianne S. , Sletten Marit , Sandset Per Morten , Iversen Nina , Stavik Benedicte , Tinholt Mari 
Published: November 2021

AbstractMost breast cancers express estrogen receptor (ER) where estrogen signaling plays an important role. Cancer contributes to activation of the coagulation system leading to an imbalance in the hemostatic system, and coagulation factor (F) V, which is a key regulator of blood coagulation, has been shown to be increased in breast tumors. Thus, the molecular association between estrogens and FV was explored. Stimulation with 17-β-estradiol (E2) or 17-β-ethinylestradiol (EE2) resulted in a time- and dose-dependent increase in F5 messenger RNA and FV protein in ERα-positive MCF-7 cells. Pretreatment with the ER antagonist fulvestrant or knockdown of ERα prior to stimulation with E2 counteracted this effect. Three ERα-binding half-sites were identified in the promoter region of the F5 gene in silico. Reporter gene analysis showed that all three half-sites were involved in the estrogen-induced gene regulation in vitro, as the effect was abolished only when all half-sites were mutated. High F5 levels in ER-positive breast tumors were associated with increased relapse-free survival of breast cancer patients.
Primary Renal Neuroblastoma Mimicking Wilms Tumor
Authors: Kaur Kanwaljeet , Meena Jagdish Prasad , Sri Prasanth , Gupta Aditya Kumar , Jana Manisha , Iyer Venkateswaran K. , Kumar Rakesh , Seth Rachna 
Published: November 2021

AbstractNeuroblastoma (NB) is the most common extracranial solid malignancy in children younger than 5 years of age. It is an aggressive malignancy with evidence of secondary metastasis at the time of the initial presentation. NB is rightly known as a great masquerader. Herein, we describe three children who presented with renal masses mimicked as Wilms tumor initially and later diagnosed as NB on biopsy. The response to therapy was not satisfactory in all three children. A higher level of awareness and early recognition is important for diagnosing and managing NB. We should rule out NB when there is a diagnostic dilemma before nephrectomy in these patients. Intrarenal NB should be considered with the combination of renal mass and hypertension with elevated catecholamines. The distinction between these two tumors is important since both malignancies have different therapeutic and prognostic implications.
Cancer Vaccine in Solid Tumors: Where We Stand
Authors: Roy Somnath , Ghosh Joydeep , Ghosh Ranti 
Published: November 2021

AbstractCancer immunotherapy has achieved landmark progress in the field of medical oncology in the era of personalized medicine. In the recent past, our knowledge has expanded regarding how tumor cells escape from the immune system, introducing immunosuppressive microenvironments, and developing tolerance. Therapeutic cancer vaccine leads to activation of immune memory that is long-lasting, safe, and effective; hence, it is becoming an attractive method of immunotherapy. Various cancer vaccine trials in the past have taught us the types of target selection, magnitude of immune response, and implementation of appropriate technologies for the development of new successful cancer vaccines. Tumor-associated antigens, cancer germline antigens, oncogenic viral antigens, and tumor-specific antigens, also known as neoantigens, are potential targets for designing therapeutic cancer vaccines. Cancer vaccine could be cell based, viral vector based, peptide based, and nucleic acid based (DNA/RNA). Several preclinical and clinical studies have demonstrated the mechanism of action, safety, efficacy, and toxicities of various types of cancer vaccines. In this article, we review the types of various tumor antigens and types of cancer vaccines tested in clinical trials and discuss the application and importance of this approach toward precision medicine in the field of immuno-oncology.
Candida Tropicalis Spondylodiscits in an Immunocompetent Host: A Case Report and Literature Review
Authors: Lopes Arthur , Andrade Rafael Albanez , Andrade Rebeca Gonelli , Zirpoli Bianca Berardo Pessoa , Maior Arthur Burgos Souto , Silva Gabrielly Aguiar de Lima , Andrade Marcelo 
Published: November 2021

Abstract
Background Fungal spondylodiscitis is not common but should be suspected in some cases. Candida tropicalis infections are being more frequently diagnosed due to some factors related to the microorganism.
Case Description A C. tropicalis spondylodiscitis is described in a 72-year-old man who was treated with a combination of echinocandin (micafungin) and surgery.
Conclusion The presence of some risk factors should promptly raise the suspicion of fungal spondylodiscitis. Treatment should be instituted as early as possible for the best outcome for the patient.
Heparin-Induced Fever in Neurointensive Care Unit: A Rarity Yet a Possibility
Authors: Krishnakumar Mathangi , Naik Shweta S. , Ramesh Venkatapura J. , Mouleeswaran S 
Published: November 2021

AbstractFever is considered a protective response having multitude of benefits in terms of enhancing resistance to infection, recruiting cytokines to the injured tissue, and promoting healing. In terms of an injured brain, this becomes a double-edged sword triggering an inflammatory cascade resulting in secondary brain injury. It is important to identify the etiology so that corrective measures can be taken. Here we report a case of persistent fever in a patient with Guillain-Barré syndrome, which was probably due to heparin. This is the first report of heparin-induced fever in a neurocritical care setting and third report overall.
Voltage-gating and cytosolic Ca
2+
activation mechanisms of
Arabidopsis
two-pore channel AtTPC1
Authors: Ye Fan , Xu Lingyi , Li Xiaoxiao , Zeng Weizhong , Gan Ninghai , Zhao Cheng , Yang Wei , Jiang Youxing , Guo Jiangtao 
Published: November 2021

Significance

How membrane potential drives conformational change at the voltage-sensing domain (VSD) and regulates channel gating is a central theme for voltage-gated ion channels. To elucidate voltage-gating mechanisms, one needs to capture VSD structures in both the activated state and resting state, the latter of which is difficult to obtain because VSDs tend to adopt an activated state in the absence of membrane potential in most in vitro experiments. Here, we determined AtTPC1 structures in a closed conformation with a resting VSDII and an unbound EF-hand domain and in a partially open conformation with an activated VSDII and a Ca
2+
-activated EF-hand domain, elucidating the structural mechanisms of voltage gating, cytosolic Ca
2+
activation, and their coupling in AtTPC1.
Physiology of milk production and modelling of the lactation curve
Authors: Angeles-Hernandez Juan Carlos , Aranda-Aguirre Edgar , Muñoz-Benítez Alfonso Longinos , Chay-Canul Alfonso J. , Albarran-Portillo Benito , Pollott Geoffrey Ernest , Gonzalez-Ronquillo Manuel 
Published: November 2021

Abstract
Lactation is defined as the combined processes of synthesis, secretion, and excretion of milk, starting at calving and continuing until natural or induced drying off in the lactating female. Milk production follows a common pattern in several mammalian species known as a lactation curve. A typical lactation curve starts at day four after calving, reaching peak yield in early lactation, followed by a daily decrease in milk yield (persistency) until the lactating female is artificially dried off, or the lactation comes to a natural end. Mathematical models have been applied to lactation curves to provide information in relation to lactation curve parameters, providing valuable information for herd management and breeding decisions. Therefore, the aim of this study was to review the most used mathematical models for the prediction of dairy production curves. The importance of modelling lactation curves is to predict the yield for each day with the minimum possible error, to be able to elucidate the underlying pattern of milk production in the presence of local variation associated with the effect of the environment. The usefulness of any model of adjustment to the lactation curve depends on its capacity to mimic the biological process of developing milk production and to adjust the factors that affect it. Furthermore, these models can only be used to adjust productive records adequately, or to provide a biological understanding of the lactation process.
Final report, on-going key comparison BIPM.QM-K1, ozone at ambient level, comparison with ISCIII, February 2021
Authors: Viallon Joële , Idrees Faraz , Moussay Philippe , Wielgosz Robert , Nunez-Corcuera Beatriz , Miguel Jose Miguel de , Gómez Pilar Morillo 
Published: November 2021

Main text
As part of the ongoing key comparison BIPM.QM-K1, a comparison has been performed between the ozone national standard of the Instituto de Salud Carlos III (ISCIII) and the common reference standard of the key comparison, maintained by the Bureau International des Poids et Mesures (BIPM). The instruments have been compared over a nominal ozone amount-of-substance fraction range of 0 nmol/mol to 500 nmol/mol
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Accurate prediction of the Drell-Yan

ϕη*

distribution in wide dilepton mass and rapidity ranges in pp collisions through NNLO+N3LL
Authors: Ocalan Kadir 
Published: November 2021

Abstract
This paper presents high-accuracy predictions for the differential cross ss as a function of the key observable

ϕ

η

*

of the neutral-current Drell-Yan (DY) dilepton production in proton-proton (pp) collisions. The differential distributions for the

ϕ

η

*

are presented by using the state-of-the-art predictions from the combined calculations of fixed-order perturbative quantum chromodynamics (QCD) corrections at next-to-next-to-leading order (NNLO) accuracy and resummation of large logarithmic terms at next-to-next-to-leading logarithmic (NNLL) and next-to-NNLL (N3LL) accuracies, i.e., NNLO+NNLL and NNLO+N3LL, respectively. The predicted distributions are reported for a thorough set of the DY dilepton invariant mass m

ll
ranges, spanning a wide kinematic region of 50 < m

ll
< 1000 GeV both near and away from the Z-boson mass peak, and rapidity y

ll
ranges in the central detector acceptance region of ∣y

ll
∣ < 2.4. The differential

ϕ

η

*

distributions in the wide m

ll
and y

ll
ranges offer stringent tests to assess the reliability of the predictions, where the m

ll
and y

ll
are closely correlated with the parton distribution functions (PDFs) of the incoming partons. The matched predictions through NNLO+N3LL are observed to provide good description of the 13 TeV pp collision data for the

ϕ

η

*

(including the dilepton transverse momentum

p

T

ll

as well) distributions in almost the entire m

ll
and y

ll
ranges, apart from the intermediate- to high-

ϕ

η

*

region in the lowest mass range 50–76 GeV which is assessed to constitute a challenge for the presented predictions. The predictions at NNLO+N3LL are also reported at 14 TeV for the upcoming high-luminosity running era of the Large Hadron Collider (LHC), in which increasing amount of data is expected to require more accurate and precise theoretical description. The most recent PDF models MSHT20 and CT18, in addition to the NNPDF3.1, are tested for the first time for the matched predictions of the

ϕ

η

*

distribution. The differential distributions by the combined predictions through NNLO QCD+NLO EW are finally provided to enable assessment of the impact of the EW corrections for the

ϕ

η

*

.
Updated detection prospects for relic neutrinos using coherent scattering
Authors: Shergold Jack D. 
Published: November 2021

Abstract
We review the existing proposals to detect relic neutrinos using the coherent scattering of a neutrino wind on a test mass. By considering the transformation of the neutrino momentum between reference frames, we demonstrate that the induced acceleration scales with the square of the neutrino mass for unclustered neutrinos, contrary to the existing literature. In addition, we show that there is a large contribution to this effect from coherent neutrino-electron scattering, which can exceed the neutrino-nucleus component by nearly an order of magnitude. Unfortunately, we find that even with this enhancement there are no existing experiments or proposals capable of detecting relic neutrinos using this method.
Exact solutions in higher-dimensional Lovelock and AdS
5 Chern-Simons gravity
Authors: Bajardi Francesco , Vernieri Daniele , Capozziello Salvatore 
Published: November 2021

Abstract
Lovelock gravity in D-dimensional space-times is considered adopting Cartan's structure equations. In this context, we find out exact solutions in cosmological and spherically symmetric backgrounds. In the latter case, we also derive horizons and the corresponding Bekenstein-Hawking entropies. Moreover, we focus on the topological Chern-Simons theory, providing exact solutions in 5 dimensions. Specifically, it is possible to show that Anti-de Sitter invariant Chern-Simons gravity can be framed within Lovelock-Zumino gravity in 5 dimensions, for particular choices of Lovelock parameters.
Rapid generation of functional engineered 3D human neuronal assemblies: network dynamics evaluated by micro-electrodes arrays
Authors: Muzzi L , Di Lisa D , Arnaldi P , Aprile D , Pastorino L , Martinoia S , Frega M 
Published: November 2021

Abstract

Objective. In this work we adapted a protocol for the fast generation of human neurons to build 3D neuronal networks with controlled structure and cell composition suitable for systematic electrophysiological investigations. Approach. We used biocompatible chitosan microbeads as scaffold to build 3D networks and to ensure nutrients-medium exchange from the core of the structure to the external environment. We used excitatory neurons derived from human-induced pluripotent stem cells (hiPSCs) co-cultured with astrocytes. By adapting the well-established NgN2 differentiation protocol, we obtained 3D engineered networks with good control over cell density, volume and cell composition. We coupled the 3D neuronal networks to 60-channel micro electrode arrays (MEAs) to monitor and characterize their electrophysiological development. In parallel, we generated two-dimensional neuronal networks cultured on chitosan to compare the results of the two models. Main results. We sustained samples until 60 d in vitro (DIV) and 3D cultures were healthy and functional. From the structural point of view, the hiPSC derived neurons were able to adhere to chitosan microbeads and to form a stable 3D assembly thanks to the connections among cells. From a functional point of view, neuronal networks showed spontaneous activity after a couple of weeks. Significance. We presented a particular method to generate 3D engineered cultures for the first time with human-derived neurons coupled to MEAs, overcoming some of the limitations related to 2D and 3D neuronal networks and thus increasing the therapeutic target potential of these models for biomedical applications.
Understanding core heavy impurity transport in a hybrid discharge on EAST
Authors: Shi Shengyu , Chen Jiale , Bourdelle Clarisse , Jian Xiang , Odstrčil Tomáš , Garofalo Andrea M. , Cheng Yunxin , Chao Yan , Zhang Ling , Duan Yanmin , Wu Mingfu , Ding Fang , Qian Jinping , Gao Xiang 
Published: November 2021

Abstract
The behavior of heavy/high-Z impurity tungsten (W) in the core of hybrid (high normalized beta β
N plasmas) scenario on EAST with international thermonuclear experimental reactor-like divertor is analyzed. W accumulation is often observed and seriously degrades the plasma performance (Gao et al 2017 Nucl. Fusion
57 056021). The dynamics of the W accumulation process of a hybrid discharge are examined considering the concurrent evolution of the background plasma parameters. It is found that the toroidal rotation and density peaking of the bulk plasma are usually large in the central region, which is particularly prone to the W accumulation. A time slice during the W accumulation phase is modeled, accounting for both neoclassical and turbulent transport components of W, through NEO with poloidal asymmetry effects induced by toroidal rotation, and TGLF, respectively. This modeling reproduces the experimental observations of W accumulation and identifies the neoclassical inward convection/pinch velocity of W due to the large density peaking of the bulk plasma and toroidal rotation in the central region as one of the main reasons for the W accumulation. In addition, the NEO + TGLF + STRAHL modeling can not only predict the core W density profile but also closely reconstruct the radiated information mainly produced by W in the experiment.
TEM in toroidal plasmas with anisotropic electron temperature
Authors: Yao Y. , Liu S.F. , Zhu K.E. , Kong W. , Li J.Q. , Dong J.Q. 
Published: November 2021

Abstract
Trapped electron modes (TEMs) in tokamak plasmas with anisotropies of electron temperature and its gradient are studied by solving the gyrokinetic integral eigenmode equation. Detailed numerical analyses indicate that, in comparison with that in plasmas of isotropic electron temperature, TEMs are enhanced (weakened) by the anisotropy with temperature in the direction perpendicular to magnetic field higher (lower) than that in the direction parallel to the magnetic field when the latter is kept constant. However, the enhancement is limited such that TEMs are weakened rapidly and even stabilized when the anisotropy is higher than a critical value owing to an effective reduction of bounce movement of the trapped electrons. In addition, it is found that the gradients of perpendicular and parallel temperatures of electrons have driving and suppressing effects on the TEMs, respectively. The overall effects of the temperature gradients of electrons and ions, magnetic shear, safety factor, and density gradient on TEMs in the presence of the anisotropies are presented in detail.
The Study of the 22Ne(α,γ)26Mg Reaction at LUNA
Authors: Piatti D. 
Published: November 2021

Abstract
The 22Ne(α,γ)26Mg reaction is the competitor of the 22Ne(α,γ)25Mg reaction, an effective neutron source for element synthesis through s-process in massive and AGB stars. Currently the ratio between the rates of these two reactions is poorly constrained because of the high uncertainty affecting the 22Ne(α,γ)26Mg reaction rate. Indeed a wide range of values for the 395 keV resonance strength (10−15 - 10−9 eV) is reported in literature, all of them from indirect measurements. The present study represents the first direct measurement which was performed at the ultra-low background LUNA laboratory. An high efficiency detector was installed at the gas target beamline of LUNA 400kV accelerator and the 99% enriched in 22Ne neon gas was irradiated with a 399.9 keV α-beam. No significant signal was detected in the 22Ne(α,γ)26Mg region of interest, thus an upper limit for the 395 keV resonance strength was estimated. A new campaign was completed in August 2019 with an improved setup and some details are reported here.
New COMPASS results on kaon multiplicities from SIDIS
Authors: Kabuß E-M 
Published: November 2021

Abstract
Preliminary COMPASS results on kaon multiplicities produced in semi-inclusive deep inelastic scattering of 160 GeV muons off a pure proton target are presented. The results constitute a data set of more than 600 data points, covering a large x, Q
2 and z domain in a fine binning with W > 5GeV/c2. The results from the sum of the z-integrated multiplicities M(K+)+M(K−) are presented versus x and compared to earlier COMPASS results on a deuteron target and to other experiments.
In addition, we show the K−/K+ as well as

p
¯

/p multiplicity ratios measured for hadrons carrying a large fraction z of the virtual-photon energy, 0.5 < z < 1. The data were obtained using a 160 GeV muon beam and an isoscalar 6LiD target. For values of z larger than 0.8, the results contradict expectations obtained using the formalism of (next-to-) leading order perturbative quantum chromodynamics. In particular the data show a strong dependence upon the missing mass Mx
, not expected from the calculations. The results suggest that additional corrections to the formalism may be required to take into account the phase space available for hadronization.
Measurement of Longitudinal Single-Spin Asymmetry for W± Production in Polarized Proton+Proton Collisions at STAR
Authors: Xu Qinghua 
Published: November 2021

Abstract
The contribution from the sea quark polarization to the nucleon spin is an important piece for the complete understanding of the nucleon spin structure. The production of W
± bosons in longitudinally polarized p+p collisions at the RHIC collider at Brookhaven National Laboratory provides a unique probe of the sea quark polarization, through the parity-violating single-spin asymmetry, AL
. At the STAR experiment, the W bosons that decay through the W → ev channel at mid-rapidity (|η <1.3) can be effectively determined with the Electromagnetic Calorimeters and Time Projection Chamber. The STAR measurements of AL
for W boson from datasets taken in 2011 and 2012 at

s

=510 GeV have been included in the global analysis of polarized parton distribution functions, and provided significant constraints on the helicity distribution functions of

u
¯

and

d
¯

quarks. The final AL
results from 2013 STAR data sample are reported, which is about three times larger than the total integrated luminosity of previous years. The combined results of AL
for 2011-2013 data are also given. A flavor asymmetry of light sea quark helicity distribution,

Δ

u
¯

(
x
)

−

Δ

d
¯

(
x
)
>
0

, is confirmed from a re-weighting of global analysis NNPDFpol1.1 after including the new AL results. In addition, results on the double-spin asymmetries ALL
for W
±, and AL
for Z/γ* production are also reported.
Morphological and magnetic features of columnar nanostructures CuO
Authors: Ushakov A V , Karpov I V , Fedorov L Yu , Demin V G 
Published: November 2021

Abstract
Columnar nanostructures (CNS) were grown by plasma chemical synthesis at a gas mixture pressure of 90% He + 10% O2 200 Pa and substrate temperatures of 340K (sample 1) and 370K (sample 2). The effect of substrate temperature on the morphological, crystalline, magnetic, and impedance properties of CNS was studied. Scanning microscopy (SEM) showed that the morphology of CNS varies significantly from dendritic to wire structure. Energy dispersive X-ray spectroscopy (EDS) showed a change in the stoichiometry of the deficiency samples (Cu52O48) to an excess of oxygen (Cu42O58). X-ray diffraction analysis (XRD) and Rietveld fitting showed that samples 1 and 2 have a monoclinic crystal structure with a large proportion of the amorphous phase, the size of coherent scattering regions (CSR) was 26 nm (sample 1). Magnetic measurements showed that sample 1 exhibits ferromagnetic behavior, and at 6 K a magnetic hysteresis loop appears. Sample 2 from 250 K to room temperature exhibits diamagnetic behavior. A connection was found between the appearance of diamagnetism and a jump in the dielectric constant of sample 2. An assumption was made about the electron-ionic nature of the diamagnetism of sample 2.