bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increases of Phospho-Tau (Ser202/Thr205) in the Olfactory Regions Are Associated With Impaired EEG and Olfactory Behavior in Traumatic Brain Injury Mice
Authors: Yoon Younghyun , Seol YunHee , Kim Su-Hyun , Im Hyoenjoo , Han Hio-Been , Choi Jee Hyun , Ryu Hoon 
Published: September 2021

Abstract
Traumatic brain injury (TBI) leads to long-term cognitive impairments with an increased risk for neurodegenerative and psychiatric disorders. Among these various impairments, olfactory dysfunction is one of the most common symptoms in TBI patients. However, there are very few studies that show the association between olfactory dysfunction and repetitive TBI, which accounts for the majority of all head injuries. In this present study, we investigated the effects of repetitive TBI on olfactory functioning and the related pathological neuronal injuries in mice. Through pathological examination, we found a significant increase in p-Tau (S202/T205) in olfactory bulb-associated areas such as the Anterior Olfactory Nucleus (AON), Pyriform Cortex (PC), Tenia Tecta (TT), and Olfactory Tubercle (OT). Neuronal atrophy in the Lateral Anterior Olfactory Nucleus (AOL), Granule Layer Olfactory Bulb (GrO), and Dorsal Tenia Tecta (DTT) was also found to be correlated with p-Tau levels. Furthermore, electroencephalography (EEG) of repetitive TBI mouse models showed impaired spontaneous delta oscillation, as well as altered cross-frequency coupling between delta phase and amplitudes of the fast oscillations in the resting-state olfactory bulb. Also, abnormal alterations in EEG band powers were observed during the olfactory oddball paradigm test. This study provides evidence of pathological and physiological alterations in the mouse olfactory system caused by repetitive TBI. Together, p-Tau alterations and EEG impairments may serve as important biomarkers of olfactory track-associated dysfunctions and behavioral impairments commonly observed in repetitive TBI patients.
HnRNP G Reduces Neuron Death in Amyotrophic Lateral Sclerosis by Preventing Abnormal TDP-43 Accumulation
Authors: Yang Fang , Chen Wenzhi , Zhu Yu , Jiang Shishi , Wang Xiaohua , Xu Renshi 
Published: September 2021

Abstract
Heterologous ribonucleoprotein (hnRNP) G protein was found to significantly down-regulated in the spinal cord of amyotrophic lateral sclerosis (ALS) mouse model in our previous study, but the down-regulated effects of hnRNP G in ALS haven’t been known up to now. Therefore, we further studied the possible effects of hnRNP G on spinal neuron death in TG(SOD1*G93A)1Gur (TG) mice. Eighteen TG mice and eighteen SOD1 wild-type (WT) mice were divided into 6 groups. The hnRNP G of the spinal cord was analyzed using immunofluorescent histochemistry and Western blot. hnRNP G-siRNA was transfected into PC12 cells and observed the alteration of proliferation rate and intracellular proteins using the CCK8 and Western blot. We reported that the distribution of hnRNP G positive cells in the posterior horn was more than that in the central canal and its surrounding gray matter more than that in the anterior horn. hnRNP G protein mainly expressed in neurons. hnRNP G expression in the cervical and thoracic segments of TG mice in the pre-onset group was significantly higher than that in the control group. hnRNP G expression in the thoracic and lumbar segments of TG mice in onset group was lower than that in control group. hnRNP G expression in the cervical and thoracic segments of TG mice in progressive group decreased, while that in the lumbar segment of TG mice in progression group significantly increased. After hnRNP G was silenced, the proliferation rate of PC12 cells was slower than that in the control group, SOD1 expression didn’t significantly change, both TDP-43 and Bax expression significantly increased in PC12 cells after silenced. Our study revealed that the distribution of hnRNP G in the spinal cord of ALS mice showed the possible protective effect on the progression of ALS, its mechanism maybe prevent neuron death by reducing abnormal TDP-43 accumulation in the spinal cord of ALS-like mice.
Intrinsic Parametric Approach to Groundwater Vulnerability Assessment: A Case Study of Ijero Mining Site, Ijero-Ekiti.
Authors: Falade Ayodele O. , Oni Temitope E. , Oyeneyin Akinfolayan 
Published: September 2021

Abstract
The research was conducted to unravel the aquifer protective capacity and groundwater yield of the environment of a mining site at Ijero-Ekiti, Nigeria. The electrical resistivity method was employed and data gotten were used in combining the conventional longitudinal conductance and a new approach that indexes the resistivity and thickness considering some layers which could be protective and have low resistivity like clay material. The area is characterized by the Nigeria Basement Complex consisting of Precambrian rocks, made up of the migmatite gneiss, amphibole schist, quartzite, calc gneiss, schist biotite gneiss, biotite-schist, epidiorite, pegmatite and granite. A total of 9 points were sounded with maximum current electrode separation of 50 – 80 m. The sounding data were interpreted with the aid of partial curve-matching and computer iteration. Result of the interpretation of the geophysical data shows that the area is composed of variable subsurface layering that ranges from three to four layers. Groundwater potential zones were delineated based on the geo-electrical data. The study reveals that VES 1, 3, 4, 5 and 8 have high to medium groundwater potential. However, VES 2, 6 and 9 are characterized by low groundwater potential. The distinct aquifer protective zones identified in the study area using longitudinal conductance and geoelectric layer susceptibility indexing are poor and weak. The study has been able to detect the groundwater yield and the protective capacity of the overburden in the northeastern part of Ijero-Ekiti where a mining site is located using electrical method. Geochemical analysis of water and soil samples from the area is recommended to understand the right treatment required for some of the groundwater sources for drinking.
Dietary Sodium Restriction in the Management of Chronic Kidney Disease: A Systematic Review and Meta-Analysis of RCTs
Authors: Manikandan Sai Sidharth , Dhar Murali 
Published: September 2021

Abstract
Background: Non-pharmacological strategies such as lowering sodium intake aim to protect renal function and delay the initiation of renal replacement therapy. It might also be a cost-effective method to improve chronic kidney disease (CKD) prognosis. We decided to perform a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of low versus high sodium intake in adults with CKD. Results:Our search strategy yielded seven studies from six countries with 465 participants. The overall effect on restricted sodium intake favored reduction in systolic blood pressure with an overall mean difference of -6.14(95% CI: -9.52, -2.76) and reduction in diastolic blood pressure with a mean difference of -3.08 (95% CI: -4.62, -1.55). There was lowering of estimated glomerular filtration rate (eGFR), however the same was not statistically significant.Conclusion:The study found that restricted salt intake could significantly reduce systolic and diastolic BP. Further, multi-center RCTs for longer durations across different stages of CKD could effectively assess the effects of restricted sodium intake on vital parameters. Such study designs could also help clinicians identify the optimal intake of dietary sodium to achieve better renal and cardio vascular outcomes.
Development and Validation of a Six-lncRNA Prognostic Signature in Gastric Cancer
Authors: Zeng Huihui , Nai Ai tao , Ma Feng , BASHIR SHOAIB , Li Yin , Xu Meng 
Published: September 2021

Abstract
Background: Gastric cancer (GC) has been a leading cause of cancer-related mortality for many years. It is thought that long noncoding RNAs (lncRNAs) can play a significant role in GC. This study aimed to construct a powerful six-lncRNA signature as a prognostic biomarker for GC patients.Methods: Based on The Cancer Genome Atlas (TCGA), the expression profiles of lncRNAs and the corresponding clinical data of GC patients were obtained. Cox regression and the least absolute shrinkage and selection operator (LASSO) regression model were used to identify the prognostic lncRNA signature. A total of 337 patients were included in the combined dataset (N = 337), which was divided into a training dataset (N= 169) and a test dataset (N = 168). The reliability of the lncRNA prognostic signature was validated in three datasets.Results: A six-lncRNA prognostic signature was constructed to predict the overall survival (OS) of GC patients. The signature had better discriminability than clinical characteristics. The prognostic risk score was as follows: (expression level of RP11-284F21.7×-0.243981) + (expression level of RP11-432J22.2×-0.502378) + (expression level of RP4-584D14.5×-0.447878) + (expression level of AC093850.2×0.261822) + (expression level of AP000695.6 ×0.654318) + (expression level of AC098973.2× 0.406603). In addition, the signature was confirmed to be a significant predictor for predicting the OS. The nomogram model precisely predicted the OS of GC. Enrichment analysis indicated that the signature was mainly enriched for extracellular matrix-related functions and tumor signaling pathways. The target genes IGFBP7, VCAN, and COL1A1 had prognostic value in GC. AC098973.2 and RP11-284F21.7 was verified for the first time in GC tissues and cell lines.Conclusions: The six-lncRNA prognostic signature could predict the OS and has high clinical application value in GC.
Effect of Hemoglobin on the Prognosis of Patients with Advanced Cancer in Palliative Care Settings
Authors: liao xinghe , Bao Cihang , Liu Minghui , Chen Menglei , Gu Xiaoli , Zhang Zhe , Zhang Jin , Zhang Chenyue , Zhao Weiwei , Cheng Wenwu 
Published: September 2021

Abstract
Background: Hemoglobin is a prognostic factor for many cancer patients. However, its effect on the prognosis of patients with advanced cancer receiving palliative treatment is still unclear.Objective: The aim of this study was to assess whether hemoglobin can be used as a prognostic indicator for patients with advanced cancer receiving palliative treatment.Methods: From July 2013 to October 2015, 368 consecutive patients were treated in the palliative treatment center of the Shanghai Cancer Center of Fudan University. The data for 105 patients were extended in the follow-up. The cut-off value selected for hemoglobin was 100 g/L.Results: The median survival time of patients with low hemoglobin was shorter than that of patients with high hemoglobin (41 days vs. 84 days). In the follow-up readmission cohort (n = 105), the median survival time for patients with high hemoglobin (HHb → HHb) was 3.44 times longer than that of patients with low hemoglobin (HHb → LHb). Thus, both low hemoglobin and decreased hemoglobin were identified as independent prognostic factors for poor prognosis.Conclusions: In palliative treatment, hemoglobin can be used as a stratification factor to determine the prognosis of advanced cancer patients.
Effectiveness of case management interventions in reducing common and potentially preventable complications associated with Parkinson’s disease:A systematic review and meta-analysis
Authors: Halteren Angelika D. van , Daalen Jules M. Janssen , Ypinga Jan H.L. , Bloem Bastiaan R. , Meinders Marjan J. , Munneke Marten , Darweesh Sirwan K.L. 
Published: September 2021

Abstract
Objective

We sought to systematically examine the effectiveness of case management interventions on common and potentially preventable complications associated with Parkinson’s disease, both in persons with Parkinson’s disease and in persons with other chronic health conditions. We specifically focused on falls, depression, anxiety, hallucinations, urinary tract infections and swallowing impairments.
Background

There is no systematic insight in the effect of case management on common complications associated with Parkinson’s disease. This is an important knowledge gap given that people living with Parkinson's have identified care coordination as one of their highest priorities. Furthermore, it remains unclear whether the putative beneficial effects of case management would vary by key patient characteristics, such as their age, gender or disease characteristics. Such insights would contribute to a shift from “one size fits all” healthcare resource allocation to personalized medicine.
Methods

Using predefined inclusion criteria, we identified studies published up till February 2021 from PubMed and Embase databases. For each study, data were extracted independently by two researchers. Narrative analysis, and when possible also meta-analysis and random-effects analyses were undertaken.
Results

23 randomized controlled trials and four non-randomized studies reported data on the effect of case management on feelings of anxiety (8 studies) or symptoms of depression (26 studies). Only one study was conducted in people with Parkinson’s disease. No study were identified that reported on how case management affected falls, hallucinations, urinary tract infections or swallowing impairments. Across meta-analyses, we observed a statistically significant effect of case management on reducing anxiety (Standardized Mean Difference [SMD] = − 0.47; 95% confidence interval [CI]: -0.69, -0.32) and depression (SMD = − 0.48; CI: -0.71, -0.25). We found a large heterogeneity in effect estimates across studies, but this was not explained by patient population or intervention characteristics.
Conclusions

Among people with chronic health conditions, case management has beneficial effects on symptoms of depression and feelings of anxiety, which are two common complications of Parkinson’s disease. However, these findings were based almost exclusively on interventions in people with other diseases. Future studies should assess the utility of case management for preventing complications in people with Parkinson’s disease, with a particular focus on the optimal content, frequency, and intensity of case management.
Molecular Docking Studies on the Anti-Fungal Activity of Allium Sativum (Garlic) Against Mucormycosis (Black Fungus) by BIOVIA Discovery Studio Visualizer 21.1.0.0
Authors: Sharma Shaweta , Sharma Akhil , Gupta Utsav 
Published: September 2021

Abstract
Background: The COVID-19 pandemic is a major concern. However, its association and rising cases of mucormycosis, also known as black fungus make the scenario even more troublesome. In addition, no specific medication against mucormycosis/black fungus makes things even worse.Objective: Garlic phytoconstituents have shown remarkable antifungal properties against various fungal species in various studies. Thus, the objective of the study was to check the potency of garlic phytoconstituents against the 1,3-beta-glucan synthase fungal protein using in-silico methods.Method: Auto Dock was used to evaluate selected garlic phytochemical molecules against 1,3-beta-glucan synthase fungal protein, and Discovery studio visualizer was used to create 3D and 2D interaction photos.Results: Five out of 9 phytoconstituents were found to form conventional hydrogen bonds, and only alliin formed the highest number of hydrogen bonds. However, the binding energy and inhibition constant of all nine phytoconstituents were determined. Interestingly, Z-ajoene showed the lowest binding energy of -5.07 kcal/mol and inhibition constant of 192.57µM.Conclusion: The results of our investigation suggested that garlic phytochemicals can have a good impact against black fungi, pertaining to the significant binding energies of phytoconstituents during blind docking. Specifically, Z-ajoene could be a good alternate against black fungi. However, detailed research is required to explore the antifungal activity of garlic against mucormycosis.
Social Media Research on "Laminate Veneer": During Covid 19-Pandemic
Authors: DEMIREKIN Zeynep , BUYUKCAVUS Esra 
Published: September 2021

Abstract
Objective: The difficulty of asking questions to each other during the appointment process with their doctor, the long waiting times of the patients in the waiting rooms in the clinics, and the fact that it is easier to get medical information on the internet due to the ongoing COVID-19 virus infection. Porcelain laminate veneers (PLVs) have been frequently used to restore anterior teeth for nearly three decades, thanks to their aesthetic appeal, durability and biocompatibility.Methods: YouTube™ was searched by a researcher of this study using the keyword 'laminate veneer' on April 17, 2021. The most frequently used terms in this regard are 'laminate veneer' and 'laminate veneer restoration'. Analyzes were made on the Instagram application, along with YouTube.Results: Thirty-three videos were determined on YouTube™ on the topic of laminate veneer. The mean number of the views was 46277.84 ± 128674.71, with the minimum view as ten and maximum as 682478. The videos had a mean duration of 5:48 ± 4:64 with a range of 0:24–14:55. The mean number of "likes" for each video was 198 ± 424, and the mean number of "dislikes" was 17 ± 48. The most-liked video received 1700 "likes." The most-disliked video received 236"dislikes." The mean number of comments was 13.65 ± 31.58. The interaction rate was 1.67 ± 5.18, and the viewing rate was 2939.11 ± 6076.75Conclusion: YouTube™ and Instagram still cannot be accepted as a completely confident resource of knowledge for patients who want to learn about oral aesthetic rehabilitation treatment with laminate veneers
Research an Online Monitoring Method of Propulsion Shafting Alignment Adapting to Hull Deformation
Authors: Cheng Jianwei , Shi Liang , Zhang Yuanchao , Bu Wenjun 
Published: September 2021

Abstract
Hull deformations are caused by factors such as loading status, wave load, diving depth of underwater vehicles, etc. This causes a change in the shafting alignment state of the ship's propulsion shafting.This affects the alignment state of the ship propulsion shafting. It is very important for engineering significance to research an online monitoring method of propulsion shafting alignment that adapts to the influence of hull deformation. Based on Euler's rigid body attitude theory, this paper constructs a spatial attitude relationship model of the main and driven shafts of the ship's propulsion shafting. By converting to a fixed earth coordinate system, their absolute position-posture can be obtained. Using laser displacement sensor measurement technology, an online monitoring method of propulsion shafting alignment that adapts to the influence of hull deformation is established, which was verified by experiments. This method is suitable for situations where both the main shaft and the driven shaft may have rigid body posture changes. It can provide shafting alignment control compensation for the influence of hull deformation under different working conditions. This will greatly reduce the operating noise of the shaft system and the mechanical operation failure caused by the misalignment of the ship's propulsion shafting.
Experience and Perspectives of Infection Prevention Staff of the COVID-19 Response in Australian Hospitals
Authors: Baswa Alisha , Stewardson Andrew , Ayton Darshini , Russo Phillip , Doyle Joseph 
Published: September 2021

Abstract
Background Hospital infection prevention and control (IPC) staff have played a key role in adapting and implementing jurisdictional COVID-19 policy during the current pandemic. We aimed to describe the experiences of IPC staff in Australian hospitals during the COVID-19 pandemic to inform future pandemic preparedness plans.Methods A cross-sectional study involving an online survey distributed to IPC practitioners employed in Australian hospitals. Survey content was informed by in-depth interviews, and addressed work conditions, redeployed workforce, personal protective equipment, communication, and guidelines. Participants were recruited through the mailing lists of Australasian College of Infection Prevention and Control and the Australasian Society of Infectious Diseases.Results We received fully or partially completed responses from 160 participants, including 38 (24%) and 122 (76%) with nursing and medical backgrounds, respectively. Respondents reported access to sufficient information about PPE (75%, 114/152), PPE was of sufficient quantity (77%, 117/152) and was of sufficient quality (70%, 106/152). Barriers to infection prevention guideline implementation included frequently changing guidelines (57%, 84/148), timing of updates (65%, 96/148) and contradictory sources of information (64%, 95/148). Respondents described a need for better communication channels from government authorities to hospital IPC teams. All respondents described an increase in workload leading to difficulty completing work (63%, 97/154) and feeling burnt out (48% 74/154)Conclusions These data identify avoidable barriers to implementation of COVID-19 infection prevention guidance in Australian hospitals. These findings can inform future national preparedness strategies.
Low incidence of surgical pathology in infants with bilious vomiting
Authors: Cummins David Andrew , Kuschel Carl 
Published: September 2021

Abstract
Background: Bilious vomiting in the neonate is an important presenting sign of intestinal obstruction. We conducted a review of the presentation and management of term neonates admitted with bilious vomiting (BV) to determine the incidence of a surgical pathology in our population.  Design: Retrospective cohort study using a prospectively maintained database.  Participants: All term infants admitted to NICU with BV at the Royal Women’s Hospital Melbourne during a 5-calendar year period.  Results: All 153 babies had at least one imaging study. 128 (83.7%) had plain abdominal radiographs. 127 (83%) underwent upper gastrointestinal contrast scan (UGI) and 103 (67.3%) had both. 6 (3.9%) UGI studies were abnormal, with 3 babies (1.9%) subsequently having surgical pathology (2 volvulus, 1 Hirschsprung disease). Only 6 (3.9%) babies in our cohort had a surgical pathology identified (4 Hirschsprung disease, 2 malrotation). Babies with surgical pathology were more likely to present later (median 40 hours versus 23 hours). Abdominal distension was highly sensitive for surgical pathology.  Conclusion: The incidence of surgical pathology in this cohort was low compared to other studies. It is more likely in infants presenting with BV after 24 hours.
Advanced Hybrid Machine Learning Algorithms for Multistep Lake Water Level Forecasting
Authors: Fijani Elham , Khosravi Khabat , Barzegar Rahim , Quilty John , Adamowski Jan , Kheyrollah-Pour Homa 
Published: September 2021

Abstract
Random Tree (RT) and Iterative Classifier Optimizer (ICO) based on Alternating Model Tree (AMT) regressor machine learning (ML) algorithms coupled with Bagging (BA) or Additive Regression (AR) hybrid algorithms were applied to forecasting multistep ahead (up to three months) Lake Superior and Lake Michigan water level (WL). Partial autocorrelation (PACF) of each lake’s WL time series estimated the most important lag times — up to five months in both lakes — as potential inputs. The WL time series data was partitioned into training (from 1918 to 1988) and testing (from 1989 to 2018) for model building and evaluation, respectively. Developed algorithms were validated through statistically and visually based metric using testing data. Although both hybrid ensemble algorithms improved individual ML algorithms’ performance, the BA algorithm outperformed the AR algorithm. As a novel model in forecasting problems, the ICO algorithm was shown to have great potential in generating robust multistep lake WL forecasts.