bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Lipoprotein(a)-Associated Mortality and the Estimated Glomerular Filtration Rate Level in Patients Undergoing Coronary Angiography: A 51,500 Cohort Study
Authors: Huang Zhidong , Yang Yanfang , Lu Jin , Liang Jingjing , He Yibo , Yu Yaren , Huang Haozhang , Li Qiang , Wang Bo , Li Shanggang , Yan Zelin , Xu Danyuan , Liu Yong , Chen Kaihong , Huang Zhigang , Ni Jindong , Liu Jin , Chen Liling , Chen Shiqun 
Published: November 2021

Background: High lipoprotein(a) is associated with poor prognosis in patients at high risk for cardiovascular disease. Renal function based on the estimated glomerular filtration rate (eGFR) is a potential risk factor for the change of lipoprotein(a). However, the regulatory effect of eGFR stratification on lipoprotein(a)-associated mortality has not been adequately addressed.Methods: 51,500 patients who underwent coronary angiography (CAG) or percutaneous coronary intervention (PCI) were included from the Cardiorenal ImprovemeNt (CIN) study (ClinicalTrials.gov NCT04407936). These patients were grouped according to lipoprotein(a) quartiles (Q1–Q4) stratified by eGFR categories (&lt;60 and ≥60 mL/min/1.73m2). Cox regression models were used to estimate hazard ratios (HR) for mortality across combined eGFR and lipoprotein(a) categories.Results: The mean age of the study population was 62.3 ± 10.6 years, 31.3% were female (n = 16,112). During a median follow-up of 5.0 years (interquartile range: 3.0–7.6 years), 13.0% (n = 6,695) of patients died. Compared with lipoprotein(a) Q1, lipoprotein(a) Q2–Q4 was associated with 10% increased adjusted risk of death in all patients (HR: 1.10 [95% CI: 1.03–1.17]), and was strongly associated with about 23% increased adjusted risk of death in patients with eGFR &lt;60 mL/min/1.73m2 (HR: 1.23 [95% CI: 1.08–1.39]), while such association was not significant in patients with eGFR ≥60 mL/min/1.73m2 (HR: 1.05 [95% CI: 0.97–1.13]). P for interaction between lipoprotein(a) (Q1 vs. Q2–Q4) and eGFR (≥60 vs. eGFR &lt;60 mL/min/1.73m2) on all-cause mortality was 0.019.Conclusions: Elevated lipoprotein(a) was associated with increased risk of all-cause mortality and such an association was modified by the baseline eGFR in CAG patients. More attention should be paid to the patients with reduced eGFR and elevated lipoprotein(a), and the appropriate lipoprotein(a) intervention is required.
Weight Loss Outcomes Among Early High Responders to Exenatide Treatment: A Randomized, Placebo Controlled Study in Overweight and Obese Women
Authors: Rodgers Megan , Migdal Alexandra L. , Rodríguez Tahereh Ghorbani , Chen Zsu-Zsu , Nath Anjali K. , Gerszten Robert E. , Kasid Natasha , Toschi Elena , Tripaldi Juliet , Heineman Brent , Phan Minh , Ngo Long , Maratos-Flier Eleftheria , Dushay Jody 
Published: November 2021

ObjectiveAs there is significant heterogeneity in the weight loss response to pharmacotherapy, one of the most important clinical questions in obesity medicine is how to predict an individual’s response to pharmacotherapy. The present study examines patterns of weight loss among overweight and obese women who demonstrated early robust response to twice daily exenatide treatment compared to those treated with hypocaloric diet and matched placebo injections.MethodsWe randomized 182 women (BMI 25-48 kg/m2) to treatment with exenatide alone or matched placebo injections plus hypocaloric diet. In both treatment groups, women who demonstrated ≥ 5% weight loss at 12 weeks were characterized as high responders and those who lost ≥10% of body weight were classified as super responders. Our primary outcome was long-term change in body weight among early high responders to either treatment. An exploratory metabolomic analysis was also performed.ResultsWe observed individual variability in weight loss with both exenatide and hypocaloric diet plus placebo injections. There was a trend toward a higher percentage of subjects who achieved ≥ 5% weight loss with exenatide compared to diet (56% of those treated with exenatide, 76% of those treated with diet, p = 0.05) but no significant difference in those who achieved ≥ 10% weight loss (23% of individuals treated with exenatide and 36% of those treated with diet, p = 0.55). In both treatment groups, higher weight loss at 3 months of treatment predicted super responder status (diet p=0.0098, exenatide p=0.0080). Both treatment groups also demonstrated similar peak weight loss during the study period. We observed lower cysteine concentrations in the exenatide responder group (0.81 vs 0.48 p &lt; 0.0001) and a trend toward higher levels of serotonin, aminoisobutyric acid, anandamide, and sarcosine in the exenatide super responder group.ConclusionIn a population of early high responders, longer term weight loss with exenatide treatment is similar to that achieved with a hypocaloric diet.Clinical Trial Registrationwww.clinicaltrialsgov, identifier NCT01590433.
Orexin-A in Patients With Lewy Body Disease: A Systematic Review and Meta-Analysis
Authors: Gan Jinghuan , Chen Zhichao , Han Jiuyan , Ma Lingyun , Liu Shuai , Wang Xiao-Dan , Ji Yong 
Published: November 2021

BackgroundAbnormal orexin-A levels in cerebrospinal fluid (CSF) have been identified in Alzheimer’s disease (AD) and other neurodegenerative diseases. However, few studies have focused on Lewy body disease (LBD) and often with debatable outcomes. Thus, we performed this systematic review and meta-analysis to investigate orexin-A levels in LBD by incorporating data from different studies.MethodsWe gathered studies comparing orexin-A levels in patients with LBD and controls (including healthy controls and other dementia subtypes). In the initial search, 117 relevant articles were identified. After a selection process, seven studies, conducted in Japan, USA, Spain, Switzerland, France, Italy, and Netherlands, were chosen.ResultsIn total, 179 patients with LBD and 253 controls were included. Patients with LBD had significantly lower mean orexin-A CSF levels when compared with patients with AD [standard mean difference (SMD): −0.35, 95% confidence interval (CI): −0.70 to −0.00, Z = 1.96, P = 0.05], whereas mean orexin-A levels were significantly higher when compared with patients with frontotemporal lobar degeneration (FTLD) (SMD: 0.61, 95% CI: 0.23–0.99, Z = 3.12, P = 0.002). Orexin-A CSF levels in LBD patients were approximately equal to levels in healthy elderly individuals, whereas they were significantly decreased in LBD patients with excessive daytime sleepiness (EDS) (SMD: -0.15, 95% CI: -0.59 to 0.29, Z = 0.67, P = 0.50).ConclusionsWe showed that orexin-A levels in patients with LBD were not very different from those in normal elderly individuals, whereas they were lower than those in AD patients and higher than those in FTLD patients. The influence of hypersomnia on orexin-A levels should be carefully interpreted.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42021265900.
The Effect of Physical Activity on Glycemic Variability in Patients With Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Zhu Xingyun , Zhao Lina , Chen Jing , Lin Chu , Lv Fang , Hu Suiyuan , Cai Xiaoling , Zhang Li , Ji Linong 
Published: November 2021

PurposeThe effect of physical activity on glycemic variability remains controversial. This meta-analysis aimed to assess the overall effect of physical activity treatment on glycemic variability in patients with diabetes.MethodsPubMed/MEDLINE, Embase, and Cochrane databases were searched for clinical trials that conducted in patients with type 1 diabetes mellitus and type 2 diabetes mellitus with reports of the mean amplitude of glycemic excursion (MAGE), time in range (TIR), time above range (TAR), or time below range (TBR). Eligible trials were analyzed by fixed-effect model, random effect model, and meta-regression analysis accordingly.ResultsIn total, thirteen trials were included. Compared with the control group, physical activity intervention was significantly associated with increased TIR (WMDs, 4.17%; 95% CI, 1.11 to 7.23%, P&lt;0.01), decreased MAGE (WMDs, -0.68 mmol/L; 95% CI, -1.01 to -0.36 mmol/L, P&lt;0.01) and decreased TAR (WMDs, -3.54%; 95% CI, -5.21 to -1.88%, P&lt;0.01) in patients with diabetes, but showed insignificant effects on TBR. Patients with higher baseline BMI levels was associated with a greater decrease in MAGE (β=-0.392, 95% CI: -0.710, -0.074), and patients with lower baseline HbA1c levels was associated with a greater increase in TBR during physical activities (β=-0.903, 95% CI: -1.550, -0.255).ConclusionPhysical activity was associated with significantly decreased glycemic variability in patients with diabetes. Patients with higher BMI might benefit more from physical activity therapy in terms of a lower MAGE. Hypoglycemia associated with physical activity treatment still warranted caution, especially in patients with intensive glycemic control.Systematic Review RegistrationPROSPERO [CRD42021259807].
Safety of EVO ICL Implantation With an Ophthalmic Viscosurgical Device-Free Technique in the Early 24 h After Surgery
Authors: Zhang Zhe , Niu Lingling , Zhao Jing , Miao Huamao , Chen Zhuoyi , Shen Yang , Chen Xun , Ye Yuhao , Wang Xiaoying , Zhou Xingtao 
Published: November 2021

Purpose: To compare the safety of the non-ophthalmic viscosurgical device (OVD) technique with that of the minimum OVD technique in EVO Implantable Collamer Lens (EVO-ICL) implantation.Methods: A total of 180 eyes of 90 consecutive patients were enrolled in the study, of which 100 eyes of 50 patients were treated with non-OVD technique, with a 55% success rate. The remaining 80 eyes of 40 patients were treated with min-OVD technique, so they were classified into the min-OVD group. Preoperative and postoperative intraocular pressure (IOP) measurements were collected and analyzed at 1, 2, 3, and 24 h. Visual acuity, corneal endothelial cell density (ECD), and corneal densitometry 24 h postoperatively were evaluated.Results: No significant difference was found in visual outcomes (P = 0.54) or ECD (P = 0.78) between the two groups. The operation time was significantly shorter in the non-OVD group (P &lt; 0.0001). The IOP was significantly higher at 1 h (P &lt; 0.0001), 2 h (P &lt; 0.0001) and 3 h (P = 0.0045) postoperatively in the min-OVD group. The non-OVD group had significantly lower IOP than the min-OVD group at 1 h (P = 0.01) and 2 h (P = 0.013) postoperatively. The temporal corneal densitometry in the non-OVD group were significantly lower than those in the minimum group (P = 0.0063) 1 day after surgery.Conclusion: The non-OVD technique is safe and efficient for ICL implantation. It can be a safer method of ICL implantation in that it completely eliminates ophthalmic viscoelastic devices related complications without causing additional complications in short term.
Low Molecular Weight Heparin Improves the Inflammatory State of Acute Sinusitis Rats Through Inhibiting the TLR4-MyD88-NF-κB Signaling Pathway
Authors: Wu Tong , He Sihan , Jiao Zan , Liang Xiang , Chen Yu , Liu Huow , Zhang Yongq , He GuangX 
Published: November 2021

Introduction: Low molecular weight heparin (LMWH), a natural sulfated glycosaminoglycan with an affinity for proangiogenic factors, is produced by chemical or enzymatic depolymerization of unfractionated heparin (UFH). Known for its anticoagulant effects, LMWH has recently been reported to have a strong anti-inflammatory effect on colitis, myocarditis, and airway inflammation. However, as a newly-developed drug, its anti-inflammatory mechanism in upper respiratory tract inflammation has not been well-studied.Methods: SD rats were randomly divided into control and experimental groups. The experimental group was established by building an acute nasal sinusitis model with expansion sponges mixed with Streptococcus pneumoniae. Then the experimental group rats were subcutaneously injected with different concentrations of LMWH. After seven consecutive days of injection, some rats were sacrificed, and blood and nasal mucosa samples were taken to determine their inflammation status. The remaining acute sinusitis rats were randomly selected for a week of nasal irrigation with normal saline or saline mixed with different concentrations of LMWH. One week later, rats were sacrificed, and samples of blood and nasal mucosa were taken to determine the inflammation status.Results: Rat nasal mucosa in the model group had obvious inflammation. The degree of nasal mucosa inflammation damage in the experimental group was lower than in the experimental control group, proving that LMWH has a protective effect on the nasal mucosa and that the effect correlates with dosage. Irrigation of the nose with saline mixed with LMWH can improve the anti-inflammatory effect. Protein related to the TLR4-MyD88-NF-κB signaling pathway was activated in the acute sinusitis rat model, and LMWH can significantly inhibit its expression.Conclusion: This is the first report of the anti-inflammatory effect of LMWH in acute upper respiratory tract inflammation, together with an explanation of its anti-inflammatory mechanism. The findings contribute a theoretical basis for its potential anti-tumor effect.
The Association Between the Number of Consecutive Night Shifts and Insomnia Among Shift Workers: A Multi-Center Study
Authors: Sim Juho , Yun Byung-Yoon , Lee Jiho , Kim Sung Kyung , Lee Seunghyun , Cho Ara , Kim Seunghan , Kim Chang-young , Oh Yeon Suh , Yoon Jin-Ha 
Published: November 2021

Objectives: There is a need to determine the optimal limit of consecutive night shift work to reduce insomnia caused by the accumulation of sleep problems among night shift workers. This study aimed to investigate the prevalence of insomnia caused by consecutive night shifts and evaluate the night shift duration that worsens insomnia the most, using a large amount of medical examination data.Methods: Night shift profiles and baseline demographics data of three hospitals were collected from January 2015 to December 2017. For subjects who had been examined more than once at the same institution, information corresponding to the most recent date was used. Multivariate logistic regression was performed to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Pooled ORs were calculated by using the results of the three institutions.Results: Of the 33,669 participants, 31.3% were female. The average age was 41.1 ± 11.1 years and the prevalence of insomnia was 38.7% (n = 13,025). After adjusting for potential confounders and compared to workers who reported not working in consecutive night shifts, odds of insomnia were greatest among workers reporting working three consecutive nights (OR 2.65, 95% CI 1.97–3.56) followed by those working two nights (OR 1.81, 95% CI 1.45–2.26), five nights (OR 1.78, 95% CI 1.56–2.03), and four nights (OR 1.68, 95% CI 1.55–1.82).Conclusion: Our study demonstrates a significant relationship between consecutive night shift and insomnia with multicenter examination data, using common data model. This study could be a basis for establishing policies and guidelines that improve night shift workers' health.
Evaluation of Variability in Gait Styles Used by Dogs Completing Weave Poles in Agility Competition and Its Effect on Completion of the Obstacle
Authors: Eicher Logan D. , Markley Arielle Pechette , Shoben Abigail , Sundby Annika E. , Kieves Nina R. 
Published: November 2021

Objective: The aim of this study was to evaluate and define paw placement patterns for canines completing the weave pole obstacle during canine agility trials. The secondary objectives were to determine the most efficient running style and completion percentages and provide a basis for future studies to evaluate the long-term implications of variants in weave style and predisposition to injury. We hypothesized that dogs would display definitive gait patterns and that a single stepping pattern would yield faster run times compared to double stepping patterns.Animals: A total of 1,377 video recordings of dogs completing weaves poles at the American Kennel Club 2019 National Agility Championship were viewed.Procedures: Competition videos were reviewed as dogs attempted completion of the weave pole obstacle. Data collected included front limb and rear limb paw placement styles, time to complete the obstacle, and demographic data.Results: Attempts could be classified into one of five styles based on front and rear paw placement, with no one style dominant. Weave style differed by height and breed, with taller dogs and Border Collies preferring a single stepping style. Weave times were significantly faster for competitors using a single stepping style vs. other gaits.Conclusions and Clinical Relevance: This study found five identifiable gait styles used by dogs running weave pole obstacles, with front feet single stepping yielding significantly faster run times compared to other gaits. A clear classification of running styles will allow future studies to evaluate different stresses on joints, such as the shoulder, between varying gait styles, which could lead to recommendations for injury prevention.
Molecular Typing and Antimicrobial Susceptibility Profiles of Streptococcus uberis Isolated from Sheep Milk
Authors: Rosa Nives Maria , Duprè Ilaria , Azara Elisa , Longheu Carla Maria , Tola Sebastiana 
Published: November 2021

Intramammary infections are a major problem for dairy sheep farms, and Streptococcus uberis is one of the main etiological agents of ovine mastitis. Surveys on antimicrobial resistance are still limited in sheep and characterization of isolates is important for acquiring information on resistance and for optimizing therapy. In this study, a sampling of 124 S. uberis isolates collected in Sardinia (Italy) from sheep milk was analyzed by multilocus-sequence typing (MLST) and pulsed field gel electrophoresis (PFGE) for genetic relatedness. All isolates were also subjected to antimicrobial susceptibility analysis by the disk diffusion test using a panel of 14 antimicrobials. Resistance genes were detected by PCR assays. MLST analysis revealed that the isolates were grouped into 86 sequence types (STs), of which 73 were new genotypes, indicating a highly diverse population of S. uberis. The most frequently detected lineage was the clonal complex (CC)143, although representing only 13.7% of all characterized isolates. A high level of heterogeneity was also observed among the SmaI PFGE profiles, with 121 unique patterns. Almost all (96.8%) isolates were resistant to at least one antimicrobial, while all exhibited phenotypic susceptibility to oxacillin, amoxicillin-clavulanic acid and ceftiofur. Of the antimicrobials tested, the highest resistance rate was found against streptomycin (93.5%), kanamycin (79.8%) and gentamicin (64.5%), followed by novobiocin (25%) and tetracycline-TE (19.3%). Seventy-four (59.7%) isolates were simultaneously resistant to all aminoglycosides tested. Seventeen isolates (13.7%) exhibited multidrug resistance. All aminoglycosides-resistant isolates were PCR negative for aad-6 and aphA-3′ genes. Among the TE-resistant isolates, the tetM gene was predominant, indicating that the resistance mechanism is mainly mediated by the protection of ribosomes and not through the efflux pump. Three isolates were resistant to erythromycin, and two of them harbored the ermB gene. This is the first study reporting a detailed characterization of the S. uberis strains circulating in Sardinian sheep. Further investigations will be needed to understand the relationships between S. uberis genotypes, mastitis severity, and intra-mammary infection dynamics in the flock, as well as to monitor the evolution of antimicrobial resistance.
PKM Pemberdayaan Perempuan di UMKM Biovina Herbal untuk Perbaikan Pengeringan Bahan Baku Herbal Standar BPOM
Authors: Pandiangan Dingse , Nainggolan Nelson 
Published: November 2021

UMKM Biovina didirikan para perempuan dan ibu rumah tangga yang tergabung bersama untuk tujuan memproduksi tumbuhan obat tradisional yang masih dalam bentuk jamu. UMKM ini masih dalam tahap perintisan dan semua aspek pengelolaannya masih manual dan konvensional. Melalui program PKM (Program Kemitraan Masyarakat) yang dilakukan oleh LPPM Unsrat melalui program pengabdian dilakukan perbaikan pengeringan yang terkendala jika musim penghujan yang sering mengalami kerusakan yang tidak terstandar BPOM. Kegiatan atau program ini dilakukan untuk memperbaiki kualitas pengeringan bahan baku di UMKM tersebut. Adapunmetodepelaksanaan yang akan pada program iniyaitu penyuluhan, pelatihan, pendampingan dan evaluasi terhadapaspek-aspekyangmenyebabkanmasalahUMKM tersebut. Proses perbaikan yang dilakukan adalah melalui pembangunan area pengeringan yang higienis dan alat-alat pelengkapnya dengan membangun teras rumah produksi Biovina dengan atap seng tembus sinar matahari sebagian dan yang lainnya atap seng tertutup untuk pengeringan yang tidak kena sinar matahari. Hasil evaluasi menunjukkan bahwa bahan baku obat yang bisa dikeringkan dapat meningkat sampai 5-10 Kg berat basah yang sebelumnya hanya 0,5 Kg. Luarandari programini meliputiprodukBiovinadalambentukkapsulyangsudahdikemasdalambotol dan kotakdan alatpengeringan simplisiayang standar diterapkan diUMKM Biovina. Target dan luaran kegiatan PKM ini adalah memberikan motivasi dan inovasi yang baru kepada masyarakat terutama kepadai ibu-ibu rumah tangga yang tergabung dalam UMKM Biovina Sea Mitra untuk memperbaiki proses pengeringan bahan baku sebelum digunakan atau dioleh jadi produk Biovina
Results of Rectangular and Triangular Shaped Scleral Flaps in Trabeculectomy in Terms of Control of Intra Ocular Pressure (IOP) and Complications
Authors: Qurban Qirat , Kamil Zeeshan , Mahmood Khalid 
Published: November 2021

Purpose: To compare between the results of rectangular and triangular shaped scleral flaps in trabeculectomy for primary open angle glaucoma.
Study design: Quasi experimental study
Place and Duration of Study: Khalid eye clinic, Karachi, from July 2018 to June 2019.
Methods: This study included 24 patients of either gender and age from 40 to 65 years. Patients with a diagnosis of primary open angle glaucoma refractory to medical treatment were included by convenient sampling technique. They were divided into two groups. Group A underwent trabeculectomy with rectangular shaped scleral flap whereas Group B underwent trabeculectomy with triangular shaped scleral flap. The main outcome measures were intraocular pressure reduction, anterior chamber depth and post-operative complications. All patients were followed up for a period of two months.
Results: Mean age was 52.1± 6.72 years. Mean pre-operative intraocular pressure in group A was 24.4±2.13 mmHg and 23.5±1.64 mmHg in group B. Mean post-operative IOP was 11.6±1.51 mmHg in group A and 13.4±1.67 mmHg in group B with p-value of 0.11. Pre-operative anterior chamber depth (ACD) was grade 4 both groups. It remained same in all patients of group A but two patients of group B changed to grade 3 ACD. Two patients of group B developed hypotony on the first post-operative day. They did not require revision suturing and were managed conservatively.
Conclusion: Both types of scleral flap are effective in reducing IOP but rectangular scleral flap reduced IOP more as compared to triangular scleral flap but the difference was not statistically significant.
Keywords: Trabeculectomy, Intra ocular pressure, Open angle glaucoma.