bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new seven level boost-type ANPC inverter topology for photovoltaic applications
Authors: M. Jagabar Sathik , Almakhles Dhafer J. 
Published: November 2021

AbstractDeveloping of new photovoltaic inverter topologies is received more attention in the last few years. In particular, designing an active neutral-point-clamping inverter type structure is quite popular for PV applications. The output voltage is always half of the input voltage (vin), which further increases the voltage rating of dc-link capacitors in the conventional three-level ANPC. To rectify the above problem and increase the output voltage by reducing dc-link capacitors voltage rating, a new boost type seven-level ANPC inverter topology is proposed. The proposed topology consists of seven switches and one floating capacitor. The floating capacitor voltage is self-balanced, and the output voltage is 1.5 times higher than the input voltage. A detailed comparison for some power components, power loss and cost with other existing topologies are presented. Further, the proposed topology is validated in a prototype hardware setup for different load values.
Vibrational energies of some diatomic molecules for a modified and deformed potential
Authors: Onate C. A. , Okon I. B. , Onyeaju M. C. , Ebomwonyi O. 
Published: November 2021

AbstractA molecular potential model is proposed and the solutions of the radial Schrӧdinger equation in the presence of the proposed potential is obtained. The energy equation and its corresponding radial wave function are calculated using the powerful parametric Nikiforov–Uvarov method. The energies of cesium dimer for different quantum states were numerically obtained for both negative and positive values of the deformed and adjustable parameters. The results for sodium dimer and lithium dimer were calculated numerically using their respective spectroscopic parameters. The calculated values for the three molecules are in excellent agreement with the observed values. Finally, we calculated different expectation values and examined the effects of the deformed and adjustable parameters on the expectation values.
A demographic and clinical panorama of a sixteen-year cohort of soft tissue sarcoma patients in Brazil
Authors: de Figueiredo Luiza Ohasi , Júnior Augusto Afonso Guerra , de Assis Acurcio Francisco , Almeida Alessandra Maciel , Cherchiglia Mariângela Leal , Wainstein Alberto Julius Alves , Thuler Luiz Claudio Santos , Nogueira-Rodrigues Angélica 
Published: November 2021

AbstractLittle is known about soft tissue sarcomas (STS) in Brazil, once the federal statistics regarding estimates on incidence and mortality of the most common cancers that affect the Brazilian population currently do not include STS. This study aims to perform a broad evaluation and description of the epidemiological profile, access to treatment and main clinical outcomes of the Brazilian STS patient. A population-based cohort study of 66,825 patients who underwent procedures related to STS treatment registered in the Brazilian public health system (Sistema Único de Saúde, SUS) databases. Median age was 57 years, 30% of them older than 65 years and 50.7% of the cohort was female. The majority, 50,383 patients (75.4%), was diagnosed between 2008 and 2015. Most prevalent anatomic sites were upper and lower limbs (12.6%) and the registry of sarcomas without a specific location comprehended 29.7% of the cohort. The majority of patients resided in the Northeast (40.2% of the patients). Surgery was the first treatment modality in 77.7% of the cases. For survival analysis, only patients with stage and histological grade information were included. The 1-, 5- and 10-year survival rate of the patients was, respectively, 75.4% (95% CI = 74.1–76.7%), 43.4% (95% CI = 41.5–45.5%) and 18.6% (95% CI = 14.8–23.3%).
Remote diagnosis of surgical-site infection using a mobile digital intervention: a randomised controlled trial in emergency surgery patients
Authors: McLean Kenneth A. , Mountain Katie E. , Shaw Catherine A. , Drake Thomas M. , Pius Riinu , Knight Stephen R. , Fairfield Cameron J. , Sgrò Alessandro , Bouamrane Matt , Cambridge William A. , Lyons Mathew , Riad Aya , Skipworth Richard J. E. , Wigmore Stephen J. , Potter Mark A. , Harrison Ewen M. ,   TWIST Collaborators, Baweja K. , Cambridge W. A. , Chauhan V. , Czyzykowska K. , Edirisooriya M. , Forsyth A. , Fox B. , Fretwell J. , Gent C. , Gherman A. , Green L. , Grewar J. , Heelan S. , Henshall D. , Iiuoma C. , Jayasangaran S. , Johnston C. , Kennedy E. , Kremel D. , Kung J. , Kwong J. , Leavy C. , Liu J. , Mackay S. , MacNamara A. , Mowitt S. , Musenga E. , Ng N. , Ng Z. H. , O’Neill S. , Ramage M. , Reed J. , Riad A. , Scott C. , Sehgal V. , Sgrò A. , Steven L. , Stutchfield B. , Tominey S. , Wilson W. , Wojtowicz M. , Yang J. 
Published: November 2021

AbstractSurgical site infections (SSI) cause substantial morbidity and pose a burden to acute healthcare services after surgery. We aimed to investigate whether a smartphone-delivered wound assessment tool can expedite diagnosis and treatment of SSI after emergency abdominal surgery. This single-blinded randomised control trial (NCT02704897) enroled adult emergency abdominal surgery patients in two tertiary care hospitals. Patients were randomised (1:1) to routine postoperative care or additional access to a smartphone-delivered wound assessment tool for 30-days postoperatively. Patient-reported SSI symptoms and wound photographs were requested on postoperative days 3, 7, and 15. The primary outcome was time-to-diagnosis of SSI (Centers for Disease Control definition). 492 patients were randomised (smartphone intervention: 223; routine care: 269). There was no significant difference in the 30-day SSI rate between trial arms: 21 (9.4%) in smartphone vs 20 (7.4%, p = 0.513) in routine care. Among the smartphone group, 32.3% (n = 72) did not utilise the tool. There was no significant difference in time-to-diagnosis of SSI for patients receiving the intervention (−2.5 days, 95% CI: −6.6−1.6, p = 0.225). However, patients in the smartphone group had 3.7-times higher odds of diagnosis within 7 postoperative days (95% CI: 1.02−13.51, p = 0.043). The smartphone group had significantly reduced community care attendance (OR: 0.57, 95% CI: 0.34−0.94, p = 0.030), similar hospital attendance (OR: 0.76, 95% CI: 0.28−1.96, p = 0.577), and significantly better experiences in accessing care (OR: 2.02, 95% CI: 1.17−3.53, p = 0.013). Smartphone-delivered wound follow-up is feasible following emergency abdominal surgery. This can facilitate triage to the appropriate level of assessment required, allowing earlier postoperative diagnosis of SSI.
Long-read metagenomics of soil communities reveals phylum-specific secondary metabolite dynamics
Authors: Van Goethem Marc W. , Osborn Andrew R. , Bowen Benjamin P. , Andeer Peter F. , Swenson Tami L. , Clum Alicia , Riley Robert , He Guifen , Koriabine Maxim , Sandor Laura , Yan Mi , Daum Chris G. , Yoshinaga Yuko , Makhalanyane Thulani P. , Garcia-Pichel Ferran , Visel Axel , Pennacchio Len A. , O’Malley Ronan C. , Northen Trent R. 
Published: November 2021

AbstractMicrobial biosynthetic gene clusters (BGCs) encoding secondary metabolites are thought to impact a plethora of biologically mediated environmental processes, yet their discovery and functional characterization in natural microbiomes remains challenging. Here we describe deep long-read sequencing and assembly of metagenomes from biological soil crusts, a group of soil communities that are rich in BGCs. Taking advantage of the unusually long assemblies produced by this approach, we recovered nearly 3,000 BGCs for analysis, including 712 full-length BGCs. Functional exploration through metatranscriptome analysis of a 3-day wetting experiment uncovered phylum-specific BGC expression upon activation from dormancy, elucidating distinct roles and complex phylogenetic and temporal dynamics in wetting processes. For example, a pronounced increase in BGC transcription occurs at night primarily in cyanobacteria, implicating BGCs in nutrient scavenging roles and niche competition. Taken together, our results demonstrate that long-read metagenomic sequencing combined with metatranscriptomic analysis provides a direct view into the functional dynamics of BGCs in environmental processes and suggests a central role of secondary metabolites in maintaining phylogenetically conserved niches within biocrusts.
Whole-genome sequence analysis unveils different origins of European and Asiatic mouflon and domestication-related genes in sheep
Authors: Chen Ze-Hui , Xu Ya-Xi , Xie Xing-Long , Wang Dong-Feng , Aguilar-Gómez Diana , Liu Guang-Jian , Li Xin , Esmailizadeh Ali , Rezaei Vahideh , Kantanen Juha , Ammosov Innokentyi , Nosrati Maryam , Periasamy Kathiravan , Coltman David W. , Lenstra Johannes A. , Nielsen Rasmus , Li Meng-Hua 
Published: November 2021

AbstractThe domestication and subsequent development of sheep are crucial events in the history of human civilization and the agricultural revolution. However, the impact of interspecific introgression on the genomic regions under domestication and subsequent selection remains unclear. Here, we analyze the whole genomes of domestic sheep and their wild relative species. We found introgression from wild sheep such as the snow sheep and its American relatives (bighorn and thinhorn sheep) into urial, Asiatic and European mouflons. We observed independent events of adaptive introgression from wild sheep into the Asiatic and European mouflons, as well as shared introgressed regions from both snow sheep and argali into Asiatic mouflon before or during the domestication process. We revealed European mouflons might arise through hybridization events between a now extinct sheep in Europe and feral domesticated sheep around 6000–5000 years BP. We also unveiled later introgressions from wild sheep to their sympatric domestic sheep after domestication. Several of the introgression events contain loci with candidate domestication genes (e.g.,PAPPA2,NR6A1,SH3GL3,RFX3andCAMK4), associated with morphological, immune, reproduction or production traits (wool/meat/milk). We also detected introgression events that introduced genes related to nervous response (NEURL1), neurogenesis (PRUNE2), hearing ability (USH2A), and placental viability (PAG11andPAG3) into domestic sheep and their ancestral wild species from other wild species.
Optimizing electronic structure simulations on a trapped-ion quantum computer using problem decomposition
Authors: Kawashima Yukio , Lloyd Erika , Coons Marc P. , Nam Yunseong , Matsuura Shunji , Garza Alejandro J. , Johri Sonika , Huntington Lee , Senicourt Valentin , Maksymov Andrii O. , Nguyen Jason H. V. , Kim Jungsang , Alidoust Nima , Zaribafiyan Arman , Yamazaki Takeshi 
Published: November 2021

AbstractQuantum computers have the potential to advance material design and drug discovery by performing costly electronic structure calculations. A critical aspect of this application requires optimizing the limited resources of the quantum hardware. Here, we experimentally demonstrate an end-to-end pipeline that focuses on minimizing quantum resources while maintaining accuracy. Using density matrix embedding theory as a problem decomposition technique, and an ion-trap quantum computer, we simulate a ring of 10 hydrogen atoms without freezing any electrons. The originally 20-qubit system is decomposed into 10 two-qubit problems, making it amenable to currently available hardware. Combining this decomposition with a qubit coupled cluster circuit ansatz, circuit optimization, and density matrix purification, we accurately reproduce the potential energy curve in agreement with the full configuration interaction energy in the minimal basis set. Our experimental results are an early demonstration of the potential for problem decomposition to accurately simulate large molecules on quantum hardware.
Design and synthesis of MOF-derived CuO/g-C3N4 composites with octahedral structures as advanced anode materials for asymmetric supercapacitors with high energy and power densities
Authors: Zhu Ziyang , Wei Chuanying , Jiang Di , Wu Xinru , Lu Min 
Published: November 2021

Two-component composites consisting of transition metal copper oxide (CuO) and graphite carbon nitride (g-C3N4) were successfully synthesized. This CuO/g-C3N4 displays a high reversible specific capacity (1530.4 F g−1, 2 A g−1) as an anode material.
Opportunities to Enhance Children's Communication Development at School in Underserved Communities
Authors: Zahir Mariyam Z. , Miles Anna , Hand Linda , Ward Elizabeth C. 
Published: November 2021

Purpose:
Alternative service delivery approaches are required to provide support for children with communication difficulties in underserved communities. Schools have a unique set of assets that can be utilized to provide this support. This study explored what the education sector and classrooms in the early years of schooling offer as support for children with communication difficulties in an underserved Majority World country, the Maldives. The objective was to identify opportunities to enhance support provided for these children.

Method:
A qualitative multimethod approach was used involving (a) 520 min of classroom observational data from four remote schools, (b) interviews with four special education needs teachers, and (c) an interview with a Ministry of Education official. Classroom observational data were analyzed using the Communication Supporting Classroom Observation Tool. Deductive content analysis was used to analyze the interview data.

Results:
The support system aimed to reflect the Inclusive Education Policy of the Maldives. The Ministry of Education official and teachers raised concerns regarding lack of allied health services such as speech-language therapy in schools. Teachers frequently used certain communication supporting interactions such as imitation in classrooms. Missed opportunities to enhance communication were observed, including limited use of some interaction features such as modeling language, limited planned opportunities for children to interact in class, and limited resources in the environment to develop communication in Grade 1 and 2 compared to preschool.

Conclusion:
Findings suggest building capacity among teachers and training teachers on identified classroom communication support areas to enhance support for children with communication difficulties.

Supplemental Material:

https://doi.org/10.23641/asha.17003980
Model predictive guidance for active aircraft protection from a homing missile
Authors: Shi Heng , Chen Zheng , Zhu Jihong , Kuang Minchi 
Published: November 2021

AbstractThis paper proposes a novel guidance law based on model predictive control for protecting an aircraft from a homing missile. Considering that in the target‐missile‐defender engagement the attacking missile is pursuing the target aircraft by employing a known linear guidance law, a non‐linear predictive model for the engagement is established. This predictive model allows converting the three‐body engagement to a one‐on‐one engagement. The time‐to‐go for the defender towards the future position of the incoming missile is analytically derived, indicating that the optimal time for the defender to intercept the incoming missile is a fixed‐point of a real‐valued function. As a result, the optimal interception duration can be obtained by a standard fixed‐point iteration method, and thus the interception point can be readily predicted via integrating the predictive model. The guidance command is generated by directly leading the defender to the predicted intercept point. Numerical simulations in different scenarios validate the algorithm to be computationally efficient, and demonstrate that the proposed strategy outperforms previous techniques in terms of miss distance, engagement duration, and the control effort.
Homöopathische Behandlung von ADHS und Tic-Störungen
Authors: Reschke Nonna 
Published: November 2021

ZusammenfassungADHS und Tic-Störungen gehören zu den häufigsten psychischen Störungen im Kindes- und Jugendalter. Ist ADHS eine „fabrizierte Krankheit“ oder ein ernsthafter psychopathologischer Zustand? Genetische, psychosoziale und Stressfaktoren spielen im Allgemeinen eine wichtige Rolle. Moderne Psychopharmaka führen zu strukturellen Veränderungen des Gehirns und zu einer Änderung des Verhaltens des Kindes. Durch die homöopathische Behandlung wird die psychische Dynamik der Erkrankungen positiv beeinflusst. Dieser Zusammenhang wird an 2 Fallbeispielen gezeigt.
Systematic Review and Meta-Analysis of L-Methylfolate Augmentation in
Depressive Disorders
Authors: Maruf Abdullah Al , Poweleit Ethan A. , Brown Lisa C. , Strawn Jeffrey R. , Bousman Chad A. 
Published: November 2021

Abstract
Objectives  Partial response to pharmacotherapy is common in major
depressive disorder (MDD) and many patients require alternative pharmacotherapy
or augmentation, including adjunctive L-methylfolate. Given that L-methylfolate
augmentation is rarely included in major clinical practice guidelines, we sought
to systematically review evidence for L-methylfolate augmentation in adults with
MDD and to examine its efficacy meta-analytically.
Methods  We systematically searched PubMed for articles up to December 31,
2020, following the Preferred Reporting Items for Systematic Reviews and
Meta-Analyses (PRISMA) recommendations. Included studies were published in
peer-reviewed, English-language journals and examined L-methylfolate adjunctive
therapy in depressive disorders or its effect on antidepressant response. A
fixed- and random-effects meta-analysis and risk of bias assessment using the
Cochrane Risk of Bias Tool were conducted.
Results  Qualitative assessment of nine articles (N=6,707
patients) suggests that adjunctive L-methylfolate improved antidepressant
response. In the meta-analysis of categorical Hamilton Rating Scale for
Depression-17 response, (three studies, N=483) adjunctive
L-methylfolate was associated with a small effect versus antidepressant
monotherapy (relative risk: 1.25, 95% confidence interval
[CI]=1.08 to 1.46, p=0.004). A meta-analysis of four
studies (N=507) using a continuous measure of depressive symptoms
showed a similar effect of adjunctive L-methylfolate (standardized mean
difference=− 0.38, 95%
CI=− 0.59 to−0.17, p=0.0003).
Conclusion  Adjunctive L-methylfolate may have modest efficacy in
antidepressant-treated adults with MDD.
Crohn's Disease Increases In-Hospital Lengths of Stay, Medical Complications, and Costs of Care following Primary Total Knee Arthroplasty
Authors: Hadid Bana , Buehring Weston , Mannino Angelo , Weisberg Miriam D. , Golub Ivan J , Ng Mitchell K , Razi Afshin E. 
Published: November 2021

AbstractThe literature has shown an increase in prevalence of Crohn's disease (CD) within the United States alongside a concomitant rise in primary total knee arthroplasty (TKA) procedures. As such, with these parallel increases, orthopaedic surgeons will invariably encounter CD patients requiring TKA. Limited studies exist evaluating the impact of this disease on patients undergoing the procedure; therefore, this study endeavors to determine whether CD patients undergoing primary TKA have higher rates of (1) in-hospital lengths of stay (LOS), (2) medical complications, and (3) episode of care (EOC) costs. To accomplish this, a nationwide database was queried from January 1, 2005 to March 31, 2014 to identify patients undergoing TKA. The study group, patients with CD, was randomly matched to the controls, patients without CD, in a 1:5 ratio after accounting for age, sex, and medical comorbidities associated with CD. Patients consuming corticosteroids were excluded, as they are at risk of higher rates of adverse events following TKA. This query ultimately yielded a total of 96,213 patients, with 16,037 in the study cohort and 80,176 in the control one. The study compared in-hospital (LOS), 90-day medical complications, and day of surgery and total global 90-day EOC costs between CD and non-CD patients undergoing primary TKA. The results found CD patients undergoing primary TKA had significantly longer in-hospital LOS (4- vs. 3 days, p < 0.0001) compared with non-CD patients. CD patients were also found to have significantly higher incidence and odds of 90-day medical complications (25.31 vs. 10.75; odds ratio: 2.05, p < 0.0001) compared with their counterparts. Furthermore, CD patients were found to have significantly higher 90-day EOC costs ($15,401.63 vs. 14,241.15, p < 0.0001) compared with controls. This study demonstrated that, after adjusting for age, sex, and medical comorbidities, patients with CD have prolonged in-hospital LOS, increased medical complications, and higher EOC costs following primary TKA. Therefore, it establishes the importance for orthopaedists to adequately counsel CD patients of the potential complications and outcomes following their procedure.
Rolling Up the Sleeve: Equitable, Efficient, and Safe COVID-19 Mass Immunization for Academic Medical Center Employees
Authors: McDonald Samuel , Basit Mujeeb A. , Toomay Seth , McLarty Christopher , Hernandez Susan , Rubio Chris , Brown Bruce J. , Rauschuber Mark , Lai Ki , Saleh Sameh N. , Willett DuWayne L. , Lehmann Christoph U. , Medford Richard J. 
Published: November 2021

Abstract
Background Novel coronavirus disease 2019 (COVID-19) vaccine administration has faced distribution barriers across the United States. We sought to delineate our vaccine delivery experience in the first week of vaccine availability, and our effort to prioritize employees based on risk with a goal of providing an efficient infrastructure to optimize speed and efficiency of vaccine delivery while minimizing risk of infection during the immunization process.
Objective This article aims to evaluate an employee prioritization/invitation/scheduling system, leveraging an integrated electronic health record patient portal framework for employee COVID-19 immunizations at an academic medical center.
Methods We conducted an observational cross-sectional study during January 2021 at a single urban academic center. All employees who met COVID-19 allocation vaccine criteria for phase 1a.1 to 1a.4 were included. We implemented a prioritization/invitation/scheduling framework and evaluated time from invitation to scheduling as a proxy for vaccine interest and arrival to vaccine administration to measure operational throughput.
Results We allotted vaccines for 13,753 employees but only 10,662 employees with an active patient portal account received an invitation. Of those with an active account, 6,483 (61%) scheduled an appointment and 6,251 (59%) were immunized in the first 7 days. About 66% of invited providers were vaccinated in the first 7 days. In contrast, only 41% of invited facility/food service employees received the first dose of the vaccine in the first 7 days (p < 0.001). At the vaccination site, employees waited 5.6 minutes (interquartile range [IQR]: 3.9–8.3) from arrival to vaccination.
Conclusion We developed a system of early COVID-19 vaccine prioritization and administration in our health care system. We saw strong early acceptance in those with proximal exposure to COVID-19 but noticed significant difference in the willingness of different employee groups to receive the vaccine.