bluuebunny/crossref_metadata_2025_split huggingface dataset:
¿Es necesario regular la práctica de surf durante el verano?
Authors: Santos Diego , Moreno Carrillo José Miguel 
Published: March 2021

El surf evoca un estilo de vida hedonista, errante y relajado. Unos valores que encajan perfectamente con la mentalidad millennial.
Desde una perspectiva turística, existen dos formas diferentes de consumir surf. Por un lado existen una serie de personas visitarán destinos principalmente por recorrer olas, es decir la presencia de olas es su motivación principal del viaje, mientras que existe otro colectivo, mucho mayor en números absolutos que quiere aprovechar su visita a la playa para practicar surf, es decir, es simplemente una actividad complementaria; una experiencia dentro del viaje.
Conocer las características de ambas tipologías es realmente útil para los organismos de promoción y gestión del turismo, principalmente para anticiparse a posibles problemas que puedan surgir en sus arenales y así poder garantizar una sostenibilidad económica y social en ellos antes de que los conflictos sean demasiado graves.
Reseña libro Sexual Citizens
Authors: Rosas Jiménez Carlos Alberto 
Published: March 2021

Sexual Citizens es producto de una de las investigaciones más completas que existen hasta el momento sobre el abuso sexual en los campus de las universidades[1]. Tomando como punto de referencia la Universidad de Columbia de Nueva York, este estudio aporta abundante luz para esclarecer no solo la dinámica del proceso que conduce al abuso sexual, sino que lanza tres conceptos fundamentales para aproximarse a la prevención del abuso en los campus universitarios. Combinando la atención de los proyectos de vida sexual de los estudiantes con la promoción de la ciudadanía sexual y la transformación de las geografías sexuales se sugiere una ruta hacia un mundo donde el abuso sexual sea menos común. Sin embargo, como dicen los autores, este libro no ofrece una solución como tal al problema del abuso sexual, sino que presenta una nueva forma de pensar acerca de este problema, una forma que promueva un aumento en la variedad de estudios de intervención. El propósito del libro ha sido mirar cómo las instituciones y las estructuras sociales y no cómo las psyches individuales contribuyen al abuso sexual (p. 153).

[1] Las traducciones al español son hechas por el autor de la reseña.
¿Del movimiento orgánico al post-orgánico? Cultura del movimiento y cultura del consumo en la evolución de la agricultura orgánica en Italia
Authors: Spillare Stefano 
Published: March 2021

Haciendo referencia al contexto italiano, este ensayo pretende investigar el movimiento en defensa de la agricultura orgánica, su evolución a lo largo del tiempo, su desarrollo y su entorno cultural. El objetivo es profundizar los cambios sociales y culturales que se están produciendo en la sociedad italiana, así como los que afectan a los ámbitos más específicos de la agricultura y de la alimentación.
El análisis se centra, en especial manera, en la evolución más reciente del sector que parece caracterizarse, entre otras cosas, por un giro “consumista” que se relaciona con la llamada “hipótesis de la convencionalización”, así como con el desarrollo de un movimiento que podríamos definir como “post-orgánico”.
A partir de la literatura consultada, se abordan ambas hipótesis, tratando de perfilar las posibles evoluciones del sector.
El análisis se concluye con algunas referencias a la economía solidaria y al consumo crítico: se trata, en síntesis, del contexto más prometedor para el desarrollo de un posible movimiento post-orgánico. Sin embargo, podemos decir que, por lo menos por el momento, estamos todavía en una fase embrionaria y que este movimiento se está perfilando más como una perspectiva analítica que como una identidad colectiva concreta.
La integración del inmigrante marroquí en el ámbito educativo: una propuesta desde la mediación cultural
Authors: HIRI Abdelhak 
Published: March 2021

La incorporación de niños marroquíes a la escuela española, ha hecho posible que los centros educativos españoles se conviertan en arco iris cultural y lingüístico. Sin embargo, la presencia de esa diversidad con diferentes concepciones de la educación y con dificultades de comunicación fruto de la diversidad lingüística y cultural puede condicionar, en ocasiones, el entendimiento mutuo. La necesidad de dar respuesta a esta realidad, nos ha inducido a enfatizar sobre la mediación cultural en los centros educativos, como respuesta a una educación que anda a la búsqueda de nuevas formas de enseñar y nuevos espacios de aprender, nuevas formas de convivir bajo la visión de la interculturalidad. Dicho de otro modo, resulta interesante para la integración del inmigrante marroquí, ya que, aunque hay otras experiencias en este sentido, no había un suficiente referente exclusivo para el colectivo marroquí en el ámbito educativo, por lo que esperamos que nuestro trabajo sirva para avanzar en la reflexión de la integración educativa del inmigrante marroquí.
Trends in burden of multidrug-resistant tuberculosis in countries, regions, and worldwide from 1990 to 2017: results from the Global Burden of Disease Study
Authors: Ou Zejin , Yu Danfeng , Liang Yuanhao , He Wenqiao , Li Yongzhi , Meng Yaxian , Xiong Husheng , Zhang Minyi , He Huan , Gao Yuhan , Wu Fei , Chen Qing 
Published: March 2021

Abstract
Background This study aimed to estimate the trends of multidrug-resistant tuberculosis (MDR-TB), which can be used to inform health strategies.Methods Data were collected from the Global Burden of Disease Study 2017. The estimated annual percentage change (EAPCs) were calculated to assess the trends of MDR-TB burden from 1990 to 2017.Results Globally, the ASR of MDR-TB burden including incidence, prevalence, death and disability-adjusted life years (DALYs) had pronounced increasing trends from 1990 to 1999, with the EAPCs were 17.63(95% confidence interval [CI]: 10.77 to 24.92), 17.57(95%CI: 11.51 to 23.95), 21.21(95%CI:15.96 to 26.69), and 21.90(95%CI: 16.55 to 27.50), respectively. Particularly, the largest increasing trends were seen in areas and countries of low and low-middle sociodemographic index (SDI). However, the trends in incidence, prevalence, death and DALYs of MDR-TB decreased globally from 2000 to 2017, with the respective EAPCs were −1.37(95%CI: −1.62 to −1.12), −1.32(95%CI: −1.38 to −1.26), −3.30(95%CI: −3.56 to −3.04) and −3.32(95%CI: −3.59 to −3.06). Decreasing trends of MDR-TB were observed in most regions and countries, particularly that of death and DALYs in Slovenia were −18.96(95%CI: −20.82 to −17.06) and −19.35 (95%CI: −21.10 to −17.55), respectively. Whereas the pronounced increasing trends of MDR-TB occurred in Papua New Guinea, Singapore, and Australia.Conclusions the ASR of incidence, prevalence, death and DALYs of MDR-TB showed decreasing trends from 2000 to 2017. However, the MDR-TB burden remains a substantial challenge to the TB control globally, and requires effective control strategies and healthcare.
Online Art Therapy in Elementary Schools During COVID-19: Results from A Randomized Cluster Trial and Impact on Mental Health.
Authors: Malboeuf-Hurtubise Catherine , Léger-Goodes Terra , Mageau Geneviève A. , Taylor Geneviève , Herba Catherine , Chadi Nicholas , Lefrançois David 
Published: March 2021

Abstract
Background: Emerging literature on the current COVID-19 crisis suggests that children may experience increased anxiety and depression as a result of the pandemic. To prevent such school and mental health-related problems, there is a timely need to develop preventive strategies and interventions to address potential negative impacts of COVID-19 on children’s mental health, especially in school settings. Results from previous child clinical research indicate that art-based therapies, including mindfulness-based art therapy, have shown promise increase children’s well-being and reduce psychological distress. Objective: The goal of the present pilot and feasibility study was to compare the impact of an emotion-based directed drawing intervention (experimental condition) and a mandala drawing intervention (active control condition), both group-based, delivered online and remotely, on mental health, in elementary school children (N=30), in the context of the COVID-19 pandemic. A randomized cluster trial was implemented to evaluate and compare the impact of both interventions on anxiety, depression, inattention and hyperactivity symptoms. Results: ANCOVAs revealed a significant effect of the type of drawing intervention on levels of inattention, after controlling for baseline levels. Participants in the emotion-based directed drawing group showed lower inattention scores at post-test, when compared to participants in the mandala group. Conclusion: Overall, results from this pilot and feasibility study showed that an emotion-based directed drawing intervention was more beneficial than a mandala drawing intervention on inattention symptoms of elementary school children, in the context of the current COVID-19 pandemic. From a feasibility standpoint, results indicate that the implementation of both interventions online and remotely, through a videoconference platform, is feasible and adequate in school-based settings. Further work incorporating larger sample sizes, longitudinal data and ensuring sufficient statistical power is warranted to evaluate the long-term impact of both interventions on children’s mental health.
EMBRYONAL TUMORS OF THE CENTRAL NERVOUS SYSTEM IN ADULTS: A REPORT OF THREE CASES. REVIEW OF THE LITERATURE
Authors: Matsko M. V. , Matsko D. E. , Imyanitov E. N. , Sklyar S. S. , Ulitin A. Yu. , Yakovenko I. V. , Ievleva A. G. , Ershov G. A. , Romanko A. A. , Nechaeva A. S. 
Published: March 2021

Background. Еmbryonal tumors of the central nervous system are malignant neoplasms that mainly occur in pediatric patients with a peak incidence at the age of 4 years. These tumors usually have small round blue cell histology and low differentiation.Method and case description. A report of three cases with embryonal CNS tumors of supratentorial localization has been presented. Immunohistochemical analysis classified these tumors as neuroblastoma (2 cases: Syn (+), NSE (+), CD (+) and Ki67 10/40 %; ages were 33 and 52 years) or ganglioneuroblastoma (1 case: Syn (+), NSE (+), CD 99 (+) and Ki67 40 %; age was 37 year). All patients underwent RT in a total dose of 60 Gy delivered to the area of the removed tumor and 6 cycles of adjuvant chemotherapy: patients with neuroblastoma received chemotherapy using EP regimen (cisplatin + etoposide), and patient with ganglioneuroblastoma received temozolomide.Results. An objective response to therapy was achieved in all 3 patients. The relapse-free survival (RFS) in the first case of neuroblastoma was 51 months, the overall survival (OS ) was more than 105 months (8 years 9 months); in the second case of neuroblastoma, RFS was 25 months 2 weeks and OS was more than 26 months. Both neuroblastomas contained ID H1(R132H) mutation. In the patient with ganglioneuroblastoma, the RFS was 87 months, and the OS was over 93 months (7 years, 9 months, 3 weeks).Conclusion.Supratentorial embryonal tumors of the central nervous system in adults are exceptionally rare and have a relatively favorable response to the standard treatment.
DRUG THERAPY FOR ANDROGEN-POSITIVE BREAST CANCER
Authors: Zikiryakhodjhaev A. D. , Fedenko A. A. , Starkova M. V. , Surkova V. S. , Sedova M. V. 
Published: March 2021

There are some types of breast cancer (BC) that depend on their molecular characteristics. However, lately researchers provide date regarding the presence of additional receptors of triple negative breast cancer (TNBC). One of them is LA R-subtype that has androgen receptors (AR) on breast cancer cells. The role of AR in the development of this pathology is still controversial. According to some authors, stimulation of AR leads to the proliferation suppression, in the opinion of others – to the activation and potentiation of tumor invasion. There is also a version of the dichotomous effect of androgens that depends on the concentration of this hormone. The various effects of LA R-subtype therapy of BC are also explained by the presence of many other regulator proteins that interact with AR. The first attempts to treat BC with androgen have begun since the 40s of the last century, but in those years it did not have the desired effect and was not used until recently. Currently, the basic mechanisms of the effect of androgens on BC cells on the molecular level are known, and researches try to use androgen therapy, also in combination with aromatase inhibitors to increase the concentration of endogenous testosterone. The effects of selective androgen receptor modulators and anabolic steroids are being studied. However, in the last decade, the largest number of studies focused on the study of anti-androgen therapy. Patients receive AR antagonists, such as enzalutamide, bicalutamide, that are prescribed for prostate cancer. Enzalutamide blocks both androgen- and estrogen-mediated tumor growth, and therefore can be used regardless of the presence of estrogen receptors (ER), in contrast to bicalutamide. The results showed a significant increase in disease free survival up to 16.5 months in patients with hormone positive BC.
GENDER SPECIFICITY OF COLORECTAL CANCER IN THE REPUBLIC OF TATARSTAN
Authors: Gataullin B. I. , Khasanov R. Sh. , Savelyev A. A. , Gataullin I. G. 
Published: March 2021

The purpose of the study: to develop an expert system based on the construction of a «decision tree» for predicting the 5-year survival rate of patients with colorectal cancer.Material and Methods. T he study included 654 patients with colorectal cancer (CRC) who were treated from 2013 to 2015, including 434 men and 220 women. The average age of patients was 64,1 ± 10,2 years. All patients underwent genetic analysis for the presence of a mutation in the K-ras gene from the primary tumor.Results. For the Republic of Tatarstan, there are regional features of mutation of the K-ras gene: the frequency of mutations in tumors in men was less frequent (20.3 %) than in women (37.7 %), in patients of Slavic nationality, mutations were slightly more frequent – 39 % than in Tatars – 21 %. The gender approach to assessing long-term treatment results showed that in men with colorectal cancer, the most favorable treatment results were observed in patients with tumors in stage T1–2N0M0, regardless of the differentiation of the tumor and its mutational status. Low-grade tumors with any T should be considered prognostically unfavorable in men, with the presence of regional metastases and mutation of the K-ras gene, even in the absence of distant metastases: no patient lived 5 years. Based on the construction of a «decision tree», the most favorable treatment results were observed in female patients with tumors in stage T1–2–3N0M0 at the age of 70 years (5-year survival rate of 90 %), with tumors T1–2N0M0 at the age of 70 years (5-year survival rate of 81.8 %), regardless of the tumor differentiation and its mutational status. Tumors of any differentiation are prognostically unfavorable for women of the T3–4N0 stage with the presence of distant metastases (6 % of patients lived 5 years) and lowdifferentiated stage T4N0M0 tumors (5-year survival rate of 8 %).Conclusion. G ender- and age-associated features of the development and course of CRC are relevant for oncologists to choose effective diagnostic and therapeutic measures.
COMBINATION OF LENVATINIB AND PEMBROLISUMAB IN THE TREATMENT OF ADVANCED ENDOMETRIAL CANCER: A CASE REPORT
Authors: Churuksaeva O. N. , Kolomiets L. A. , Villert A. B. 
Published: March 2021

Background. Endometrial cancer is the most common malignancy of the female reproductive system. Patients with metastatic endometrial cancer have the overall 5-year survival rate of less than 20 %. The efficacy of treatment of advanced endometrial cancer remains low; therefore, the search for novel approaches for treating endometrial cancer is of great importance.Case description. We report a case of a 68-year-old female who presented with advanced endometrial cancer with metastatic lesions found in the axillary and lumbar lymph nodes, liver and lungs. The disease progressed after third-line chemotherapy, with no deficiency in the DNA repair system. The patient was successfully treated with lenvatinib and pembrolisumab. The treatment was characterized by controlled minimal toxicity and a satisfactory quality of life. At 5 months, the patient is alive with stable disease.Conclusion. Despite the progress in treating endometrial cancer including chemotherapy and hormone therapy, the prognosis of patients with metastatic endometrial cancer is poor. The discovery of new molecular markers (MSI , PD -L1) made it possible to develop a clinical approach using a combination of pembrolizumab and lenvatinib for patients with no deficiency in the repair system, for whom, the standard chemotherapy is ineffective. The presented case gives hope for the treatment of this category of patients.
SAFETY AND EFFICACY OF THORACOSCOPIC LOBECTOMY IN PATIENTS WITH STAGE I NON-SMALL CELL LUNG CANCER
Authors: Ryabov A. B. , Pikin O. V. , Bagrov V. A. , Kolbanov K. I. , Glushko V. A. , Vursol D. A. , Amiraliev A. M. , Barmin V. V. , Aleksandrov O. A. 
Published: March 2021

Aim: to analyze short-and long-term treatment outcomes of thoracoscopic lobectomy in patients with stageI NSCLC .Material and Methods. A total of 479 NSCLC patients with clinical stage I NSCLC were treated at the Department of Thoracic Surgery of Hertzen Research Cancer Center from 2010 to 2019.Results. Conversion to thoracotomy was required in 62 (12.9 %) of patients. Postoperative complications occurred in 19.9 % of patients in the thoracoscopic group and in 25.8 % of patients in the conversion group: the mortality rates were 0.4 % and 1.6 % respectively. The most common complication was prolonged air-leak (>5 days), which was diagnosed in 11.9 % and 8.0 % of patients respectively. In patients aged >70 years, the rate of complications was 35.8 % in the thoracoscopic group and 41.2 % in the conversion group. Thoracoscopic lobectomy had advantages over thoracotomy in terms of less postoperative pain syndrome and much less decrease in FEV1 during the first postoperative days and months. In patients with pT1-2aN0M0, stage I NSCLC , the overall and disease-free 5-year survival rates were respectively 92.2 % and 86.6 % after thoracoscopic lobectomy and 87.5 % и 81.2 % after conversion.Conclusion. Thoracoscopic lobectomy is relatively safe procedure for patients with stage I NSCLC . To perform this type of surgery safely, the surgeon should pass the learning curve. Long-term outcomes were similar between patients undergoing thoracoscopic lobectomy and patients undergoing thoracotomy.
THE PROGNOSTIC SIGNIFICANCE OF MYXOID MATRIX IN RETROPERITONEAL WELL-DIFFERENTIATED LIPOSARCOMA
Authors: Volkov A. Yu. , Kozlov N. A. , Nered S. N. , Stilidi I. S. , Stroganova A. M. , Arkhiri P. P. , Antonova E. Yu. , Privezentsev S. A. 
Published: March 2021

Objective: to assess the influence of the myxoid matrix in retroperitoneal well-differentiated liposarcoma(WDLPS ) on the long-term results of surgical treatment of patients.Material and Methods. The study included 111 patients with primary retroperitoneal WDLPS who underwent radical surgical treatment in Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation. Histological slides of all surgical specimens were reviewed by experienced pathologist and reclassified according to criteria of WHO (2013) for histological subtypes of the WDLPS . Patients were divided into groups depending on presence or absence of the myxoid matrix in WDLPS and enrolled in intergroup analysis of overall (OS ) and recurrence-free (RFS) survival.Results. OS was significantly worse in the group of patients with the myxoid matrix in the tumor (p=0.002; log-rank test). The median OS was 142 (95 % CI , 108, 176) months in the group without the myxoid matrix, and 84 (95 % CI , 29, 139) months in the group with the myxoid matrix. The 5-year survival rates were 79 % and 44 % in the groups without myxoid matrix and with myxoid matrix, respectively. RFS was also significantly worse in the group of patients with the myxoid matrix than in the group of patients without the myxoid matrix (p=0.006; log-rank test). The median RFS was 55 (95 % CI , 38, 72) months in the WDLPS group without the myxoid matrix, and 31 (95 % CI , 15, 47) months in the WDLPS group with the myxoid matrix. The 2-year RFS rates were 75 % and 44 % in the groups without the myxoid matrix and with the myxoid matrix, respectively.Conclusion. The results of the study demonstrated that the presence of the myxoid matrix in WDLPS was associated with poor prognosis. We believe that the presence of the myxoid matrix in WDLPS can serve as an effective morphological marker of a less favorable prognosis for retroperitoneal WLPS .
EPIDEMIOLOGY AND CLINICO-DEMOGRAPHIC CHARACTERISTICS OF DLBCL IN THE NOVOSIBIRSK CITY
Authors: Voropaeva E. N. , Gurageva A. A. , Pospelova T. I. , Kolesnikova M. A. , Voevoda M. I. , Maksimov V. N. , Berezina O. V. , Khalzov K. V. , Churkina M. I. , Nechunaeva I. N. , Melnichenko E. V. 
Published: March 2021

Background. The annual reporting forms for malignant neoplasms do not provide for the division of lymphomas into variants. In international publications and statistical reference books of the Russian Federation, variants of non-Hodgkin’s lymphomas (NHL) are also not separated. For these reasons, a detailed assessment of the epidemiology of NHL in Russia is difficult, and data for individual variants of the disease are not provided.Purpose: to present the clinical and epidemiological characteristics of Diffuse Large B-cell Lymphoma (DL BCL ) in Novosibirsk according to the data of the City Hematology Center (CHC).Material and Methods. A retrospective analysis of primary medical documentation (case histories, outpatient charts, and immunohistochemical study reports) of 271 patients with DL BCL was performed in the period from January 1, 2013 to December 31, 2018.Results. The calculated registered primary morbidity and mortality from DL BCL in Novosibirsk for the analyzed years fluctuated slightly. The average incidence and mortality rates were 2.85 and 1.98 per 100,000 population, respectively. When analyzing the dynamics of the prevalence of DL BCL in Novosibirsk, a positive trend of annual increase in the indicator was revealed: 1.87 times over the past 6 years. In men, the tumor developed 2.6 years earlier than in women. In General, the risk of getting DL BCL after 50 years was 3 times higher than at the age of 30 years. Among patients diagnosed with primary lymphoma who underwent treatment at the Hematology department of CHC, half of the patients had DL BCL .Evaluation of the clinical characteristics showed a pronounced severity of the analyzed cohort.Conclusion. The updated quantitative and qualitative indicators of clinical and epidemiological characteristics of DL BCL in Novosibirsk for 2013–18 were obtained. These indicators can be used for further monitoring, development and implementation of measures for the prevention, diagnosis and treatment of this form of hemoblastosis.