bluuebunny/crossref_metadata_2025_split huggingface dataset:
El ciclismo femenino español en la década de 1890: salud, moda, amor y competición = Spanish women's cycling in the 1890s: Health, fashion, love and competition
Authors: Camino Alejandro 
Published: September 2021

En la década de 1890, el ciclismo en España experimentó un fuerte auge, sobre todo en hombres, pero también en mujeres. En estos diez años, el ciclismo se desarrolló tanto en la vertiente de ocio como en la competitiva. En ambos casos se generó un enconado debate entre expertos, especialmente médicos, escritores y religiosos, y los propios aficionados al ciclismo, sobre la conveniencia (o no) de que las mujeres montasen en bicicleta. A los argumentos sobre la salud y la vestimenta, que habitualmente han centrado la atención historiográfica sobre el ciclismo femenino, pronto se sumaron aquellos que hacían referencia a la posibilidad de generar espacios de sociabilidad proclives al surgimiento del amor duradero. Un campo aparte fue el ciclismo de competición, que, si bien fue apoyado por los partidarios de la bicicleta, no terminó de cuajar entre la población y no hubo muchas mujeres que se dedicasen profesionalmente a este deporte. AbstractIn the 1890s, Spanish cycling experienced a great boom, especially in men, but also in women. In those years, cycling developed both as leisure and as competition. In both cases, there was a lively debate among experts, particularly physicians, writers and religious authorities, and cycling fans, about whether riding bicycles was a suitable activity for women (physically, psychologically and socially) as well as occurred in a transnational context. Most historians who address women’s cycling have focused on the arguments about health and clothing, but there also existed the question of cycling as a space for development of strong love relationships. Competitive cycling represents a very different case; although it was encouraged by bicycle supporters, it did not take hold among the population; and there were not many women who did this sport professionally. In this article I analyse these aspects through an in-depth study of journalistic sources. Besides, I use the most up-to-date and leading bibliographic contributions of national and international historiography.
A valorização do movimento no desenvolvimento de jogos eletrônicos = La valoración del movimiento en el desarrollo de juegos electrónicos = The valuation of movement in the development of electronic games
Authors: Silva Ana Paula Salles da , Inácio Humberto Luis de Deus , Gemente Flórence Rosana Faganello , Silva Ana Márcia 
Published: September 2021

ResumoEsta pesquisa tem como objetivo investigar a trajetória da valorização do movimento no desenvolvimento de Jogos Eletrônicos desde a década de 70 até a atualidade. Trata-se de uma pesquisa documental que utilizou como fonte de dados o conteúdo de páginas eletrônicas de corporações comerciais, de sites de notícias de Jogos Eletrônicos e páginas online de jogadores. Os dados indicam que os Jogos Eletrônicos de Movimento lançados no mercado na última década reproduzem princípios de experiências realizadas em diferentes cenários, não sustentando o rótulo de inovação, sendo as principais diferenças a melhoria da qualidade dos acessórios, dos jogos e a minimização dos custos.ResumenEste estudio tiene como objetivo investigar la trayectoria de valoración del movimiento en el desarrollo de juegos electrónicos desde la década de 1970 hasta la actualidad. Se trata de una investigación documental que utilizó como fuente de datos el contenido de sitios web de corporaciones comerciales, sitios de noticias de Juegos Electrónicos y páginas en línea de jugadores. Los datos indican que los Juegos Eletrócnico de Movimiento lanzados al mercado en la última década reproducen principios de experimentos llevados a cabo en diferentes escenarios, no sustentando la etiqueta de innovación, siendo las principales diferencias la mejora de la calidad de los accesorios, los juegos y la minimización de costos. AbstractThis research has objective to investigate the trajectory of the valorization of the movement in the development of Electronic Games since the 70's until today. It is a documentary research that used as a data source the content of electronic pages of commercial corporations, of news sites of Electronic Games and online pages of players. The data indicate that the Electronic Movement Games launched on the market in the last decade reproduce principles of experiences carried out in different scenarios, not sustaining the innovation label, the main differences being the improvement of the quality of the accessories, the games and the minimization of costs.
PALEOENVIRONMENTAL IMPLICATIONS OF INVERTEBRATE FECAL PELLETS (EDAPHICHNIUMISP.) AT AN ICHNOFOSSIL-RICH DINOSAUR NESTING LOCALITY, UPPER CRETACEOUS TWO MEDICINE FORMATION, MONTANA, USA
Authors: FREIMUTH WILLIAM J. , VARRICCHIO DAVID J. , CHIN KAREN 
Published: September 2021

ABSTRACTThe terrestrial feeding trace Edaphichnium lumbricatum is known from the Triassic to the Pleistocene and is characterized by tubular burrows with ellipsoidal fecal pellets, indicating substrate feeding by earthworms or other invertebrates. We describe 11 specimens attributable to Edaphichnium isp. from Egg Mountain, a terrestrial locality with a diverse fossil assemblage from the Upper Cretaceous Two Medicine Formation in Montana, USA, and assess their paleoenvironmental and paleoecological implications. These ichnofossils were recovered from a 1.5 meter stratigraphic succession comprised of calcareous siltstones and limestones with abundant fossil insect pupal cases, representing well-drained paleosols. Although burrows are not always present, three recurring arrangements of Edaphichnium isp. fecal pellets are identified: linearly arranged pellets, horizon-confined pellets, and pellets in clusters dispersed vertically and horizontally throughout the matrix. Two color patterns (light and dark pellets) are also distinguished. Pellets are fine-grained and have a consistently ellipsoidal shape (length:diameter of 1.57), with maximum lengths ranging from 1.9–6.7 mm (mean 4.1 mm) and maximum diameters ranging from 1.0–4.1 mm (mean 2.6 mm). Geochemical analyses indicate pellets are comprised of varying proportions of calcite, plagioclase, and quartz, and are enriched in phosphorus relative to the sedimentary host matrix. Possible trace makers include chafer or other coleopteran larvae, millipedes, and earthworms, suggesting a range of capable trace makers of Edaphichnium-like fecal pellets. Edaphichnium isp. at specific stratigraphic horizons suggests increased organic content in the subsurface, potentially connected to depositional hiatuses. Edaphichnium isp. adds a secondary component to the Celliforma ichnofacies known from Egg Mountain and surrounding strata, and to the array of nesting, feeding, and dwelling traces of wasps, beetles, other invertebrates, mammals, and dinosaurs from the locality.
Isotope-Geochemical Features of Apoultrabasic Metasomatites of the Sayan–Baikal Folded Area
Authors: Rampilova M.V. , Ripp G.S. , Rampilov M.O. , Damdinov B.B. , Damdinova L.B. , Posokhov V.F. 
Published: September 2021

Abstract
—The paper is concerned with a geochemical study of apoultrabasic metasomatites of the Ospa–Kitoi, Parama, and Ust’-Kelyana ophiolite massifs located in the southern folded framing of the Siberian craton. The isotope (O, C, H, Sr, and Rb) systems of dunites, serpentinites, nephrites, listvenites, and talc–carbonate rocks are studied. The isotopic composition of oxygen in olivines from dunites is characterized by δ18O = 4.6–5.5‰. The δ18O values of serpentinites (4.67–7.35‰) point to the mantle genesis of fluids and might have been inherited from ultrabasic rocks. Nephrites are slightly enriched in heavy oxygen isotope (δ18O = 6.13–9.54‰). This indicates that their fluid phase was transported from serpentinites and captured a small portion of the crustal component. The widest variations in δ18O values, from 8.12 to 17.46‰, are observed in minerals from listvenites. Carbonates from these rocks show a highly heterogeneous isotopic composition of oxygen (δ18O = 12.9–18.8‰) and carbon δ13C = –2.8 to +2.8‰). These rocks formed with the contribution of metamorphogenic fluids. According to the isotopic composition of hydrogen, the examined serpentinites are divided into two groups: with δD values specific to “magmatic water” (δD = –73.50 to –85.00‰) and those typical of meteoric fluids (δD = –151.90 to –167.20‰). The listvenites are characterized by low Rb and high Sr contents. Their 87Sr/86Sr values (0.70702–0.70971) indicate the contribution of a crustal source. The study of fluid inclusions in minerals from listvenites has shown that the rocks formed under relatively low-temperature conditions. The homogenization temperatures of fluid inclusions in quartz and magnesite from listvenites of the Ospa–Kitoi massif are 184–290 ºC and 122–182 ºC, respectively. In the Parama massif, the homogenization temperature of fluid inclusions in quartz is 130–170 ºC. The solutions that formed listvenites of the Ospa–Kitoi massif were slightly saline (TDS = 2.9–8.4 wt.% NaCl eq.), with NaCl and Na2CO3 being the main salt components.
Aedes Fluviatilis Cell Lines As New Tools To Study Metabolic And Immune Interactions In Mosquito-Wolbachia Symbiosis
Authors: Conceição Christiano Calixto , Silva Jhenifer Nascimento da , Arcanjo Angélica , Nogueira Cíntia Lopes , de Abreu Leonardo Araujo , de Oliveira Pedro Lagerblad , Gondim Katia C. , Moraes Bruno , de Carvalho Stephanie Serafim , Silva Renato Martins da , Vaz Itabajara da Silva , Moreira Luciano Andrade , Logullo Carlos 
Published: September 2021

Abstract
In the present work, we established two novel embryonic cell lines from the mosquito Aedes fluviatilis containing or not the naturally occurring symbiont bacteria Wolbachia, which were called wAflu1 and Aflu2, respectively. We also obtained wAflu1 without Wolbachia after tetracycline treatment, named wAflu1.tet. Morphofunctional characterization was performed to help elucidate the symbiont-host interaction in the context of energy metabolism regulation and molecular mechanisms of the immune responses involved. The presence of Wolbachia pipientis improves energy performance in A. fluviatilis cells; it affects the regulation of key energy sources such as lipids, proteins, and carbohydrates, increasing the speed of cell proliferation, making the distribution of actin more peripheral and with more extensions that come into contact with neighboring cells. Additionally, innate immunity mechanisms were activated, showing that the wAflu1 and wAflu1.tet cells are responsive after the stimulus using Gran negative bacteria. Therefore, this work confirms the natural, mutually co-regulating symbiotic relationship between W. pipientis and A. fluviatilis, modulating the host metabolism and immune pathway activation. The results presented here add important resources to the current knowledge of Wolbachia-arthropod interactions.
Controllability of Nonlinear Deterministic Chaotic Systems with Control-Induced Delay
Authors: Kumar Suman 
Published: September 2021

Abstract
This paper presents the analysis of a class of retarded nonlinear chaotic systems with control-induced delay. The existence and uniqueness of the mild solution are obtained by using the local Lipschitz condition on nonlinearity and Banach contraction principle. The approximate controllability for linear and nonlinear control delay systems has been established by sequence method and using the Nemytskii operator. The application of results is explained through an example of a parabolic partial differential equation.
Deep Transfer Learning Based Human Activity Recognition By Transforming IMU Data To Image Domain Using Novel Activity Image Creation Method
Authors: B.A Mohammed hashim , R Amutha 
Published: September 2021

Abstract
Human Activity Recognition is the most popular research area in the pervasive computing field in recent years. Sensor data plays a vital role in identifying several human actions. Convolutional Neural Networks (CNNs) have now become the most recent technique in the computer vision phenomenon, but still it is premature to use CNN for sensor data, particularly in ubiquitous and wearable computing. In this paper, we have proposed the idea of transforming the raw accelerometer and gyroscope sensor data to the visual domain by using our novel activity image creation method (NAICM). Pre-trained CNN (AlexNet) has been used on the converted image domain information. The proposed method is evaluated on several online available human activity recognition dataset. The results show that the proposed novel activity image creation method (NAICM) has successfully created the activity images with a classification accuracy of 98.36% using pre trained CNN.
Stimulated Phosphorylation of ERK in Mouse Kidney Mesangial Cells is Dependent Upon Expression of Cav3.1
Authors: Pandi Sudha Priya Soundara , Shattock Michael J. , Hendry Bruce M. , Sharpe Claire C. 
Published: September 2021

Abstract
Background: T-type calcium channels (TTCC) are low voltage activated channels that are widely expressed in the heart, smooth muscle and neurons. They are known to impact on cell cycle progression in cancer and smooth muscle cells and more recently, have been implicated in rat and human mesangial cell proliferation. The aim of this study was to investigate the roles of the different isoforms of TTCC in mouse mesangial cells to establish which may be the best therapeutic target for treating mesangioproliferative kidney diseases.Methods: In this study, we generated single and double knockout (SKO and DKO) clones of the TTCC isoforms CaV3.1 and CaV3.2 in mouse mesangial cells using CRISPR-cas9 gene editing. The downstream signals linked to this channel activity were studied by ERK1/2 phosphorylation assays in serum, PDGF and TGF-β1 stimulated cells. We also examined their proliferative responses in the presence of the TTCC inhibitors mibefradil and TH1177. Results: We demonstrate a complete loss of ERK1/2 phosphorylation in response to multiple stimuli (serum, PDGF, TGF-β1) in CaV3.1 SKO clone, whereas the CaV3.2 SKO clone retained these phospho-ERK1/2 responses. Stimulated cell proliferation was not profoundly impacted in either SKO clone and both clones remained sensitive to non-selective TTCC blockers, suggesting a role for more than one TTCC isoform in cell cycle progression. Deletion of both the isoforms resulted in cell death. Conclusion: This study confirms that TTCC are expressed in mouse mesangial cells and that they play a role in cell proliferation. Whereas the CaV3.1 isoform is required for stimulated phosphorylation of ERK1/2, the Ca V3.2 isoform is not. Our data also suggest that neither isoform is necessary for cell proliferation and that the anti-proliferative effects of mibefradil and TH1177 are not isoform-specific. These findings are consistent with data from in vivo rat mesangial proliferation Thy1 models and support the future use of genetic mouse models to test the therapeutic actions of TTCC inhibitors.
Analysis of the Immunogenicity of mRNA-1273 SARS-CoV-2 Vaccine in Breast Cancer Patients Treated With Cyclin-Dependent Kinases 4 and 6 Inhibitors (CDKi): Limited T-Cell Immunity Despite Satisfactory Humoral Response.
Authors: Saavedra Cristina , Vallejo Alejandro , Longo Federico , Serrano Juan José , Fernández María , Gion Maria , López-Miranda Elena , Martinez-Jañez Noelia , Guerra Eva , Chamorro Jesús , Rosero Diana , Velasco Héctor , Martin Adrian , Carrato Alfredo , Casado Jose Luis , Cortes Alfonso 
Published: September 2021

Abstract
SARS-CoV-2 vaccination in cancer patients has become crucial because of their higher risk of complications and death from COVID19. We performed a prospective study to assess the immunogenicity of SARS-CoV-2 vaccine in cancer patients treated with CDKi and compared their immune response with patients treated with chemotherapy. While a robust humoral response was observed in the CDKi patients compared with chemotherapy patients, limited T-cell immunity was achieved in both groups.
High-accuracy Photonics-assisted Frequency Measurement With Rough-accurate Compensation Based on Mach-Zehnder Interfering and Power Cancellation
Authors: Huang Lanfeng , Li Yongjun , Zhao Shanghong , Lin Tao , Wang Guodong , Li Xuan , Zhu Zihang 
Published: September 2021

Abstract
A high-accuracy photonics-assisted frequency measurement with rough-accurate compensation based on Mach-Zehnder interfering and power cancellation is proposed. A polarization division multiplexing dual-parallel Mach–Zehnder modulator (PDM-DPMZM) is employed to mix the unknown RF signal and sweep signal to optical field. The rough measurement is firstly performed by the interference of a Mach-Zehnder interferometer (MZI) to realize fast frequency estimation. Then, based on the rough measurement result, the accurate measurement based on power cancellation is implemented in a much narrower range, which greatly improves the efficiency of frequency measurement. The simulation results show that the amplitude comparison function (ACF) established by interference can achieve a measurement error of less than 0.3 GHz over 0.5 ~39 GHz. Moreover, thanks to the rough-accurate compensation, the accuracy can be further improved to 4 MHz. Additionally, the multiple frequency identification with a resolution of 10 MHz can also be achieved based on this system.
Integrated Pan-Cancer Analysis Reveals Distinct Clinical, Genomic and Immunological Features of the LILRB Immune Checkpoint Family in Acute Myeloid Leukemia
Authors: Xu Zi-jun , Zhang Xin-long , Jin Ye , Wang Shi-sen , Gu Yu , Ma Ji-chun , Wen Xiang-mei , Leng Jia-yan , Mao Zhen-wei , Lin Jiang , Qian Jun 
Published: September 2021

Abstract
Background

Leukocyte immunoglobulin (Ig)-like receptor Bs (LILRBs), a family of type I transmembrane glycoproteins, are known to inhibit immune activation.
Methods

We comprehensively evaluated the transcriptional levels and prognostic significances of LILRB members in a broad spectrum of cancer types, focusing on its role in AML. In addition, we systematically characterized the genomic and immune landscape in AML patients with altered LILRBs expression.
Results

Here, we show that LILRBs were significantly dysregulated in a number of cancers, especially in acute myeloid leukemia (AML). Clinically, high expression of LILRB1-LILRB4 predicted poor survival in six independent AML cohorts. Genetically, LILRB1 was associated with more mutational events than other LILRB members, and multiple genes involving in immune activation were deleted in LILRB1-high patients. Epigenetically, LILRB4 was significantly hypomethylated and marked by MLL-associated histone modifications in AML. Immunologically, LILRBs were positively associated with monocytic cells including M2 macrophages, but were negatively associated with tumor-suppressive CD8 T cells.
Conclusions

Our findings reveal critical immunological and clinical implications of LILRBs in AML, and indicate that LILRBs may represent promising targets for immunotherapy of AML.
Composition of bacterial community and isolation of bacteria responsible for diuron degradation in sediment and soil under anaerobic condition
Authors: Duc Ha Danh , Nguyen Oanh Thi 
Published: September 2021

Abstract
The herbicide diuron is extensively used in the agriculture sector and is detected widely in the environment. Although several studies on the degradation of diuron by aerobic micro-organisms have been reported, the degradation of diuron by anaerobic micro-organisms has not been received much attention. Also, no pure culture that can degrade diuron under anaerobic conditions has yet been reported. The evaluation of diuron degradation in the soil and sediment slurries showed that diuron led to a decrease in the biodiversity of the bacterial communities. Two mixed bacterial cultures, one from the soil and the other from sediment slurries, were isolated from the enrichment media under anaerobic conditions. After 30 days of incubation at 30 oC, the mixed bacterial culture from the soil degraded 84.5 ± 5.5%, and that from the sediment slurry degraded 94.5 ± 3.0% of diuron in liquid mineral medium at an initial concentration of 20 mg/L. 1-(3,4-dichlorophenylurea (DCPU), 3-(3-chlorophenyl)-1,1-dimethylurea (CPDMU), and 3,4-dichloroaniline (3,4-DCA) were the major diuron metabolites produced by both the indigenous micro-organisms and the isolated bacteria.
Insecticidal Effect of Ethnobotanical Plant Extracts Against Anopheles Arabiensis (Diptera: Culicidae) Under Laboratory Condition
Authors: Fereda Desta Ejeta , Asme Ansha , Asefa Animut 
Published: September 2021

Abstract
Background: The emergence and spread of resistant strains of malaria vectors to chemical insecticides are becoming major problem for malaria vector management. Natural plant products play a vital role to resolve the current challenge of malaria control.Objective: The current study was conducted to evaluate insecticidal effect of ethnobotanical plant extracts against the primary malaria vector, Anopheles arabiensis in Northwestern Ethiopia.Methods: Primarily, ethnobotanical plants used for Anopheles mosquito control was surveyed in Dangur district, Northwestern Ethiopia. Insecticide susceptible strains of Anopheles arabiensis mosquito were reared in insectary of tropical and infectious diseases research center, Assosa university. The larvicidal and adulticidal potentials of frequently used plant extracts against susceptible strains of laboratory colony were evaluated.Result: A total of fifteen plants were identified as ethnobotanical plants helping the local people for mosquito control. Azadirachta indica, Ocimum lamiifolium, Ocimum americanum, Moringa olifiera leaf, and Moringa olifiera seed species of local plants were found to be frequently used to kill and/or repel mosquitoes in the study district. All the plant extracts were found to have potential larvicidal activity against 4th instar larvae of An. arabiensis and only ethanol and methanol extract of A. indica and O. lamiifolium were found to have potential adulticidal effect against adult of An. arabiensis. The highest larvicidal activity was observed in ethanol extract of A. indica with 95% larval mortality and lowest LC50 of 40.73 ppm and LC90 of 186.66 ppm. The highest adulticidal activity was observed in methanol extract of A. indica with 75% adult mortality at 300 ppm and lowest LC50 of 106.65ppm and LC90 of 1293ppm. The lowest larvicidal and adulticidal activity was observed in methanol extracts of O. lamiifolium with 63.35% larval mortality and leaf extract of M. olifiera with 50% adult mortality at 300 ppm, respectively.Conclusion: ethanol extract of A. indica exerted a remarkable larvicidal effect against An. arabiensis and thus it can be used for botanical mosquito insecticide development.