bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating a digital life story app in a nursing home context – A qualitative study
Authors: Thoft Diana S. , Møller Anders K. , Møller Ann K. K. 
Published: February 2021

AbstractAims and objectivesTo evaluate how digital life stories can be used to support person‐centred care focusing on benefits and challenges experienced by the staff and the management team in a nursing home context.BackgroundLife story work can be used to support person‐centred care and help people with dementia maintain their identity. The use of digital life stories provides opportunities to easily share the content between staff and relatives and combine different types of multimedia, for example pictures, videos, text and sound.DesignSix healthcare professionals and two members of the management team at a nursing home were recruited. Participant observations with informal interviews of the formal health career were conducted in two day shifts and two night shifts. Field notes were taken during the observations. Also, individual semi‐structured interviews were held with four of the recruited participants. This article adheres to the Standards for Reporting Qualitative Research (SRQR).ResultsThemes revealed were (1) person‐centred care and life story work as interrelated approaches; (2) Pros and cons related to the My Life Story app; and how (3) Time and information and communication technology (ICT) can restrict life story work.ConclusionDigital life stories can be used to support a person‐centred care approach. However, a number of challenges exist related to digital life story work. When using digital life stories, it is important to ensure the staff time and competences needed to work with, for example an app and that visible support and encouragement are provided by the management team.Relevance to clinical practiceChallenges are revealed when life story work is embedded in the culture and everyday work of a nursing home. It is of great importance to clinical practice to be aware of and address these challenges in order to succeed with digital life story work.
The effect of vibration stimulation on intramuscular injection pain and patient satisfaction: Single–blind, randomised controlled study
Authors: Dincer Berna , Yildirim Dilek 
Published: February 2021

AbstractAims and objectivesThe aim of this study was to assess the effect of vibration stimulation application in ventrogluteal region on intramuscular injection pain and patient satisfaction.BackgroundIntramuscular injection pain caused distress for the patients and affected their compliance with the treatment.DesignThis was a prospective, single‐blind, cross‐over study. The study complied with the guidelines of Consolidated Standards of Reporting Trials (CONSORT).MethodsEighty‐four patients who applied to the adult emergency department received an intramuscular injection of amoxicillin\ cefuroxime sodium to the ventrogluteal site with and without vibration in a random order following a standard procedure by the same investigator. Pain and satisfaction were assessed immediately after the injection with Visual Analogue Scale (VAS), by a researcher blinded to the study. The data were evaluated using mean, standard deviation, percentage, Student's t‐test, paired sample t‐test, linear regression analysis and generalised linear mixed model.ResultsA total of 174 injections were analysed. The result of the study revealed that vibration decreased the severity of pain and increased the patient satisfaction.ConclusionsVibration is a non‐pharmacologic approach, which can be effective in decreasing the injection pain and increasing patient satisfaction.Relevance to clinical practiceIntramuscular injection is the most frequently used nursing practice in the clinic. The use of vibration in decreasing pain due to intramuscular applications can help increase the self‐confidence of nurses and the quality of the care they provide.
Coronavirus disease 2019 in pregnancy: Case report on maternal death in Sagar City of Central India
Authors: Rawat Sumit K. , Saad Talha , Jindal Ankur , Vyas Ashish K. 
Published: February 2021

AbstractBackgroundThe infection by SARS‐COV‐2 leading to coronavirus disease has become a worldwide pandemic. It is not clear whether the coronavirus disease (COVID‐19) and its severity differ in pregnant compared to the nonpregnant outcome.ConcernsOut of four, three pregnant women were discharged with mild symptoms but one pregnant woman admitted at 24 weeks gestation with 3 days of vomiting, breathlessness, and cough had fatal outcome.DiagnosesAfter the medical staff prepared for isolation and protection, the patients quickly underwent with series of diagnostic tests, such as laboratory, imaging, and SARS‐COV‐2 nucleic‐acid examinations.OutcomesAmong all four SARS CoV‐2 infected pregnant women, three discharged after recovery and delivered healthy babies but one had severe COVID‐19 disease. The women began to exhibit fever, reduced blood oxygen saturation, and despite the interventions, she could not be saved and succumbed to death. There is an early requirement of effective management strategies for pregnant women with COVID‐19.
Glecaprevir/pibrentasvir is safe and effective in hepatitis C patients with cirrhosis: Real‐world data from the German Hepatitis C‐Registry
Authors: Wedemeyer Heiner , Erren Peter , Naumann Uwe , Rieke Ansgar , Stoehr Albrecht , Zimmermann Tim , Lohmann Kristina , König Bettina , Mauss Stefan 
Published: February 2021

AbstractGlecaprevir/pibrentasvir is a pangenotypic direct‐acting antiviral regimen approved for treating chronic hepatitis C virus. Real‐world use of protease‐inhibitor–containing regimens requires further evaluation in patients with cirrhosis. We evaluated the real‐world safety and effectiveness of glecaprevir/pibrentasvir in patients with cirrhosis from the German Hepatitis C‐Registry who initiated treatment between 2 August 2017‐30 June 2019. Overall, 131 patients received on‐label treatment. No patient discontinued treatment due to adverse events. Four patients had serious adverse events; none were considered related to glecaprevir/pibrentasvir. Two patients had total bilirubin >5 × upper limit of normal (ULN) during treatment. Three patients had alanine aminotransferase and three patients had aspartate aminotransferase >3 × ULN. Rates of sustained virologic response were 100% (86/86) for 86 patients with available data. A total of 51 patients received off‐label treatment, of which 3 had a serious adverse event. Glecaprevir/pibrentasvir treatment was well‐tolerated and highly effective in patients with chronic hepatitis C and cirrhosis in real‐world practice.
YtkA (CtaK) and YozB (CtaM) function in the biogenesis of cytochrome c oxidase in Bacillus subtilis
Authors: von Wachenfeldt Claes , Hallgren Joel , Hederstedt Lars 
Published: February 2021

AbstractCytochrome c oxidase in the respiratory chain of bacteria and mitochondria couples the reduction of molecular oxygen to form water with the generation of a transmembrane proton gradient. Bacillus subtilis has two heme A‐containing heme–copper oxidases: the menaquinol oxidase cytochrome aa3 and the cytochrome c oxidase cytochrome caa3. By screening three collections of mutants for defective cytochrome c oxidase, we found the genes for two, new membrane‐bound assembly factors in B. subtilis: ytkA and yozB (renamed ctaK and ctaM, respectively). CtaK is a lipoprotein without sequence similarity to any protein of known function. We show that CtaK functions together with Sco1 (YpmQ) in a pathway, leading to the assembly of the CuA center in cytochrome caa3 and seems to be a functional analogue to proteins of the periplasmic CuA chaperone family (PCuAC). CtaM is required for the activity of both cytochrome caa3 and cytochrome aa3 and dispensable for the insertion of heme A into these oxidases. The orthologous Bacillus anthracis protein and the distantly related Staphylococcus aureus CtaM complemented CtaM deficiency in B. subtilis, establishing a common function of CtaM in these bacteria. As the overall result of our work, 12 different proteins are known to function in the biosynthesis of cytochrome c oxidase in B. subtilis.
A single system detects and protects the beneficial oral bacterium Streptococcus sp. A12 from a spectrum of antimicrobial peptides
Authors: Lee Kyulim , Kaspar Justin R. , Rojas‐Carreño Gisela , Walker Alejandro R. , Burne Robert A. 
Published: February 2021

AbstractThe commensal bacterium Streptococcus sp. A12 has multiple properties that may promote the stability of health‐associated oral biofilms, including overt antagonism of the dental caries pathogen Streptococcus mutans. A LanFEG‐type ABC transporter, PcfFEG, confers tolerance to the lantibiotic nisin and enhances the ability of A12 to compete against S. mutans. Here, we investigated the regulation of pcfFEG and adjacent genes for a two‐component system, pcfRK, to better understand antimicrobial peptide resistance by A12. Induction of pcfFEG‐pcfRK was the primary mechanism to respond rapidly to nisin. In addition to nisin, PcfFEG conferred tolerance by A12 to a spectrum of lantibiotic and non‐lantibiotic antimicrobial peptides produced by a diverse collection of S. mutans isolates. Loss of PcfFEG resulted in the altered spatio‐temporal arrangement of A12 and S. mutans in a dual‐species biofilm model. Deletion of PcfFEG or PcfK resulted in constitutive activation of pcfFEG and expression of pcfFEG was inhibited by small peptides in the pcfK mutant. Transcriptional profiling of pcfR or pcfK mutants combined with functional genomics revealed peculiarities in PcfK function and a novel panel of genes responsive to nisin. Collectively, the results provide fundamental insights that strengthen the foundation for the design of microbial‐based therapeutics to control oral infectious diseases.
Accommodating Embodied Thinkers
Authors: Tanton Tobias 
Published: February 2021

AbstractThe principle of divine accommodation posits that revelation is accommodated to human cognitive capacities. It is regularly cited throughout the history of theology as an exegetical tool, as a doctrinal rationale, or as a condition for theological knowledge in general. This article proposes that divine accommodation invites an engagement with cognitive science, since findings in cognitive science illuminate the human cognitive capacities to which theological knowledge is accommodated. This article aims to demonstrate the fruitfulness of such an engagement by considering how theological concepts might be accommodated to accounts of human conceptualisation emerging from cognitive science. In particular, a case study considers the ‘conceptualisation hypothesis’ from ‘embodied cognition’, an emerging paradigm in cognitive science. This hypothesis suggests that human concepts are ‘grounded’ in sensorimotor states. If this scientifically‐motivated theory applies to all human concepts, it poses a potential theological dilemma: namely, if God‐concepts are grounded in sensorimotor states they prima facie risk being idolatrous, whereas if they are not so grounded, they may be un‐conceptualisable by humans. I suggest that one way to address this dilemma is to draw upon Athanasius’ insight that the incarnation plays a crucial role in accommodating human understanding. By examining the incarnation as an accommodation to human capacities uncovered by cognitive scientists, we gain a more comprehensive account of the epistemological reason for the incarnation. This account offers new lines of thinking about debates on the doctrine of the incarnation, such as the possibility of multiple incarnations.
Outcomes of cardiac resynchronization therapy in patients with chemotherapy‐induced cardiomyopathy
Authors: Ezzeddine Fatima M. , Saliba Antoine N. , Jain Vaibhav , Villarraga Hector R. , Herrmann Joerg , Asirvatham Samuel J. , Cha Yong‐Mei 
Published: February 2021

AbstractBackgroundSeveral chemotherapy agents are associated with the development of non‐ischemic cardiomyopathy (NIC). When chemotherapy‐induced cardiomyopathy (CHIC) is associated with left bundle branch block (LBBB) and a left ventricular ejection fraction (LVEF) 35% or lower, cardiac resynchronization therapy (CRT) is often utilized to improve cardiac function and relieve symptoms.ObjectiveTo determine the echocardiographic and clinical outcomes of CRT in patients with CHIC.MethodsThe study included 29 patients with CHIC (CHIC group) and 58 patients with other types of NIC (control group) who underwent CRT implantation between 2004 and 2017. The primary endpoints were changes in LVEF, left ventricular end‐systolic diameter (LVESD), and left ventricular end‐diastolic diameter (LVEDD) at 6–18 months after CRT. The secondary outcomes included changes in left ventricular global longitudinal strain (GLS), systolic strain rate (SRS), early diastolic strain rate (SRE), and overall survival.ResultsOut of 29 patients with CHIC, 62.1% received chemotherapy for lymphoma, 13.7% for breast cancer, and 24.1% for sarcoma. The agent implicated in 93.1% of the patients was an anthracycline. Half of the patients had LBBB. The mean baseline LVEF was 28% ± 8%. The mean baseline QRS duration was 146 ± 26 ms. Twenty‐eight patients had post‐CRT follow‐up data. CRT was associated with improvement in echocardiographic outcomes in the CHIC group and the control group. There was no difference in overall survival between the two groups (log‐rank p = .148).ConclusionCRT improves left ventricular function and reverses remodeling in patients with CHIC.
Impact of High Solar UV Radiant Exposures in Spring 2020 on SARS‐CoV‐2 Viral Inactivation in the UK†
Authors: Rendell Rebecca , Khazova Marina , Higlett Michael , O’Hagan John 
Published: February 2021

AbstractPotential for SARS‐CoV‐2 viral inactivation by solar UV radiation in outdoor spaces in the UK has been assessed. Average erythema effective and UV‐A daily radiant exposures per month were higher (statistically significant, P < 0.05) in spring 2020 in comparison with spring 2015–2019 across most of the UK, while irradiance generally appeared to be in the normal expected range of 2015–2019. It was found that these higher radiant exposures may have increased the potential for SARS‐CoV‐2 viral inactivation outdoors in April and May 2020. Assessment of the 6‐year period 2015–2020 in the UK found that for 50–60% of the year, that is most of October to March, solar UV is unlikely to have a significant (at least 90% inactivation) impact on viral inactivation outdoors. Minimum times to reach 90% and 99% inactivation in the UK are of the order of tens of minutes and of the order of hours, respectively. However, these times are best case scenarios and should be treated with caution.
The Role of Slip and No Slip Behavior on Droplet Impingement
Authors: Pati A. R. , Swain B. , Mohapatra S. S. 
Published: February 2021

Abstract
For the identification of role of slip and no slip conditions at the solid–liquid interface in case of hydrophobic, superhydrophilic, and superhydrophobic surfaces, the experimentally determined velocity profiles are analyzed. Before experimentation, each surface was characterized by using scanning electron microscope (SEM), two-dimensional, and three-dimensional surface profilometer. The impact mapping results reveal that in case of hydrophobic surface, first no slip condition is achieved and then slip condition is noticed. Conversely, for superhydrophilic surface, initially slip and then no slip conditions are observed. Furthermore, in case of superhydrophobic surface, slip behavior is observed throughout the process for the dimensionless time ranges 0.06–0.94 and this behavior of the process promotes local enhancement of viscous and capillary forces. The experimentally obtained results are further tried to validate with the help of theoretical and visual observations.
Flaw Evaluation Procedure for Cast Austenitic Stainless-Steel Materials Using a Newly Developed Statistical Thermal Aging Model
Authors: Uddin Mohammed , Sallaberry Cédric , Wilkowski Gery 
Published: February 2021

Abstract
Thermal embrittlement of some cast austenitic stainless steels (CASS) occurs at reactor operating temperatures leading to very low fracture toughness. Because of their low aged toughness with high variability, flaw evaluations of CASS material need to be established with an understanding of the materials aged condition, especially since most U.S. pressurized water reactor (PWR) nuclear plants have been given plant life extensions for 60-year operation. A flaw evaluation procedure for CASS materials is presented here using a new statistical model developed to predict the toughness of fully aged CASS using the materials' chemical compositions. In this procedure, the dimensionless-plastic-zone-parameter (DPZP) analysis is used to determine when limit-load is applicable and also approximate the elastic-plastic correction factor (Z-factor) to predict the failure stress for CASS pipe/fittings with a circumferential surface crack. The procedure was validated against several CF8m pipe test results which include various pipe diameters, crack sizes, ferrite contents, failure modes. The as-developed flaw evaluation procedure was also used to determine the Z-factors for four different pipe diameters for a database of 274 pipe/elbows in U.S. PWR plants –solving 1096 sample problems to understand what range of Z-factors in U.S. PWR plants (for CF8m CASS materials). Finally, the applicability of the CF8m-based statistical model for use with CF3 and CF8 CASS materials was also verified with available test results. The outcome of this work has been implemented in an ASME boiler and pressure vessel (BPV) code case and has been approved in 2020 as Code Case N-906.
Numerical Investigation of Rayleigh–Benard Natural Convection and Entropy Generation in a Cubic Cavity With Discrete Heat Sources
Authors: Maatki Chemseddine , Ghachem Kaouther , Almeshaal Mohammed A. , Ben Khedher Nidhal , Kolsi Lioua 
Published: February 2021

Abstract
Three-dimensional (3D) natural convection with isothermal discrete heat sources in a cubical cavity has been carefully studied using the 3D vector potential–vorticity formulation. Based on the finite volume method, the governing equations are solved with a homemade computational code (written in Fortran). Assuming that all cavity vertical walls are adiabatic, the upper wall of the cavity is kept at a cold temperature. However, in the bottom face, heat sources are placed under different configurations. The size of the discrete sources, their positions, and their numbers are varied for different Rayleigh numbers. The Prandtl number is fixed at 0.71. Three-dimensional distribution of the temperature iso-surfaces, the heat transfer rate, and entropy generation is evaluated. It is found that heat transfer and entropy generation are strongly affected by the arrangement of the discrete heated sources. In conclusion, the heat transfer rate is maximized, and the entropy generation is minimized for the inline arrangement of more than two heaters compared to the diagonal one.
Pressure Loss Coefficients for VAV Terminal Units
Authors: Lankalapalli Kiran , Idem Stephen 
Published: February 2021

Abstract
This study utilizes static pressure drop data taken from one manufacturer’s catalog to develop total pressure loss coefficient correlations for single duct VAV terminal units having a circular inlet duct and a rectangular outlet. The control dampers for each box were assumed to be in their wide open position. Separate correlations are presented for cases including a plain box, as well as terminal units that have either hot water reheat coils consisting of one to four tube rows, or an electrical heating element. In every instance the correlations account for static pressure and velocity pressure changes between the box inlet and outlet, based on cross section changes. The correlations are useful for duct designers, since they facilitate the utilization of numerical duct design approaches that require extensive iterative calculations, such as the static regain method. The correlations are proposed for inclusion in duct fitting loss coefficient databases.
Design of a Mechanical Sealing Device for Robotic Water Distribution Pipe Rehabilitation
Authors: Yeung Yip Fun , Genevriere Emily , Youcef-Toumi Kamal 
Published: February 2021

Abstract
Water distribution pipe maintenance is a global concern. In this study, we propose a Rehabilitation In-Pipe Robot (R-IPR) to perform pipe rehabilitation operations and contain induced contamination. The robot features three modules: a pipe cleaning module, a mechanical sealing module, and an in-pipe manipulator module. This study emphasizes the comprehensive design of the mechanical sealing module. We introduce a multi-layer compound structure of the seal to deal with two characteristics of tuberculated pipe surfaces: 1. macroscopical surface roughness, 2. overhang in foundation profile. The prototype excels in sealing foundation overhang and requires 45% lower compression load than a baseline seal to function. The prototype seal is integrated into the R-IPR. Finally, experiments of the overall system demonstrate the successful performance of the first contamination-less in-pipe rehabilitation.
Effect of Strain Rate on Tensile Properties of Injection Molded Multiwall Carbon Nanotube Reinforced PA 6/6 Nanocomposites
Authors: Reza Sanei Seyed Hamid , Drozynski Hanna , Hetrick Dakota 
Published: February 2021

Abstract
The mechanical properties of polymers highly depend on the loading rate, however, the effect of loading/strain rate with the addition of Carbon Nanotube is not well understood. In this study, the effect of Carbon Nanotube (CNT) content on the rate dependence of polymers was studied. Injection molded mini-tensile samples with CNT content ranging from 0 to 15wt% at strain rates of .0006, .0013, .0019 and .0025 s−1 were tested. It was found that as strain rate increased, the ultimate strength and Young s Modulus of the tensile specimens increased. It was also shown that addition of CNT will lower the chain mobility of polymer and lower the polymer dependence of properties to strain rates.
Transient Vibration and Feedback Control of an Inductrack Maglev System
Authors: Wang Ruiyang , Yang Bingen , Gao Hao 
Published: February 2021

Abstract
As a new strategy for magnetic levitation envisioned in 1990s, the Inductrack system with permanent magnets (PMs) aligned in Halbach arrays has been intensively studied and applied in many projects. Due to the nonlinear, time-varying electro-magneto-mechanical coupling in such a system, the dynamic behaviors are complicated with transient responses, which in most cases can hardly be predicted with fidelity by a steady-state Inductrack model. Presented in this paper is a benchmark 2-DOF transient Inductrack model, which is derived from the first laws of nature, without any assumed steady-state quantities. It is shown that the dynamic response of the Inductrack dynamic system is governed by a set of nonlinear integro-differential equations. As demonstrated in numerical simulations with the transient model, unstable vibrations in the levitation direction occur when the traveling speed of the vehicle exceeds a threshold. To resolve this instability issue, feedback control is implemented in the Inductrack system.
In the development, an assembly of Halbach arrays and active coils that are wound on the PMs is proposed to achieve a controllable source magnetic field. In this preliminary investigation, the proposed control system design process takes two main steps. First, a PID controller is set and tuned based on a simple lumped-mass dynamic system. Second, the nonlinear force-current correlation is obtained from a lookup table that is pre-calculated by steady-state truncation of the full transient Inductrack model. With the implemented feedback control algorithms, numerical examples display that the motion of the vehicle in levitation direction can be effectively stabilized at different traveling speeds. Although only a 2-DOF transient model is used here, the modeling technique and the controller design approach developed in this work are potentially applicable to more complicated models of Inductrack Maglev systems.