bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Ischemic Stroke and COVID-19
Authors: Qureshi Adnan I. , Baskett William I. , Huang Wei , Shyu Daniel , Myers Danny , Raju Murugesan , Lobanova Iryna , Suri M. Fareed K. , Naqvi S. Hasan , French Brandi R. , Siddiq Farhan , Gomez Camilo R. , Shyu Chi-Ren 
Published: February 2021

Background and Purpose:
Acute ischemic stroke may occur in patients with coronavirus disease 2019 (COVID-19), but risk factors, in-hospital events, and outcomes are not well studied in large cohorts. We identified risk factors, comorbidities, and outcomes in patients with COVID-19 with or without acute ischemic stroke and compared with patients without COVID-19 and acute ischemic stroke.

Methods:
We analyzed the data from 54 health care facilities using the Cerner deidentified COVID-19 dataset. The dataset included patients with an emergency department or inpatient encounter with discharge diagnoses codes that could be associated to suspicion of or exposure to COVID-19 or confirmed COVID-19.

Results:

A total of 103 (1.3%) patients developed acute ischemic stroke among 8163 patients with COVID-19. Among all patients with COVID-19, the proportion of patients with hypertension, diabetes, hyperlipidemia, atrial fibrillation, and congestive heart failure was significantly higher among those with acute ischemic stroke. Acute ischemic stroke was associated with discharge to destination other than home or death (relative risk, 2.1 [95% CI, 1.6–2.4];
P
<0.0001) after adjusting for potential confounders. A total of 199 (1.0%) patients developed acute ischemic stroke among 19 513 patients without COVID-19. Among all ischemic stroke patients, COVID-19 was associated with discharge to destination other than home or death (relative risk, 1.2 [95% CI, 1.0–1.3];
P
=0.03) after adjusting for potential confounders.

Conclusions:
Acute ischemic stroke was infrequent in patients with COVID-19 and usually occurs in the presence of other cardiovascular risk factors. The risk of discharge to destination other than home or death increased 2-fold with occurrence of acute ischemic stroke in patients with COVID-19.
Clinical Relevance of Cortical Cerebral Microinfarcts on 1.5T Magnetic Resonance Imaging in the Late-Adult Population
Authors: Hilal Saima , Doolabi Arwin , Vrooman Henri , Ikram M. Kamran , Ikram M. Arfan , Vernooij Meike W. 
Published: February 2021

Background and Purpose:
Cortical cerebral microinfarcts (CMIs) have been linked with dementia and impaired cognition in cross-sectional studies. However, the clinical relevance of CMIs in a large population-based setting is lacking. We examine the association of cortical CMIs detected on 1.5T magnetic resonance imaging with cardiovascular risk factors, cerebrovascular disease, and brain tissue volumes. We further explore the association between cortical CMIs with cognitive decline and risk of stroke, dementia, and mortality in the general population.

Methods:
Two thousand one hundred fifty-six participants (age: 75.7±5.9 years, women: 55.6%) with clinical history and baseline magnetic resonance imaging (January 2009–December 2013) were included from the Rotterdam Study. Cortical CMIs were graded based on a previously validated method. Markers of cerebrovascular disease and brain tissue volumes were assessed on magnetic resonance imaging. Cognition was assessed using a detailed neuropsychological test at baseline and at 5 years of follow-up. Data on incident stroke, dementia, and mortality were included until January 2016.

Results:

Two hundred twenty-seven individuals (10.5%) had ≥1 cortical CMIs. The major risk factors of cortical CMIs were male sex, current smoking, history of heart disease, and stroke. Furthermore, presence of cortical CMIs was associated with infarcts and smaller brain volume. Persons with cortical CMIs showed cognitive decline in Stroop tests (color-naming and interference subtasks; β for color-naming, 0.18 [95% CI, 0.04–0.33],
P
interaction ≤0.001 and β for interference subtask, 1.74, [95% CI, 0.66–2.82],
P
interaction ≤0.001). During a mean follow-up of 5.2 years, 73 (4.3%) individuals developed incident stroke, 95 (5.1%) incident dementia, and 399 (19.2%) died. People with cortical CMIs were at an increased risk of stroke (hazard ratio, 1.18 [95% CI, 1.09–1.28]) and mortality (hazard ratio, 1.09 [95% CI, 1.00–1.19]).

Conclusions:
Cortical CMIs are highly prevalent in a population-based setting and are associated with cardiovascular disease, cognitive decline, and increased risk of stroke and mortality. Future investigations will have to show whether cortical CMIs are a useful biomarker to intervene upon to reduce the burden of stroke.
Green Tea and Coffee Consumption and All-Cause Mortality Among Persons With and Without Stroke or Myocardial Infarction
Authors: Teramoto Masayuki , Muraki Isao , Yamagishi Kazumasa , Tamakoshi Akiko , Iso Hiroyasu 
Published: February 2021

Background and Purpose:
The effect of green tea and coffee consumption on mortality among cardiovascular diseases survivors is unknown. We examined the association between green tea and coffee consumption and mortality among persons with and without stroke or myocardial infarction (MI).

Methods:
In the Japan Collaborative Cohort Study, 46 213 participants (478 stroke survivors, 1214 MI survivors, and 44 521 persons without a history of stroke or MI), aged 40 to 79 years at baseline (1988–1990), completed a lifestyle, diet, and medical history questionnaire and were followed up regarding mortality until 2009. The Cox proportional hazard model was used to calculate the multivariable hazard ratios with 95% CIs of all-cause mortality after adjusting for potential confounding factors.

Results:
During the 18.5-year median follow-up period, 9253 cases were documented. Green tea consumption was inversely associated with all-cause mortality among stroke or MI survivors; the multivariable hazard ratios (95% CIs) for stroke survivors were 0.73 (0.42–1.27) for 1 to 6 cups/wk, 0.65 (0.36–1.15) for 1 to 2 cups/d, 0.56 (0.34–0.92) for 3 to 4 cups/d, 0.52 (0.31–0.86) for 5 to 6 cups/d, and 0.38 (0.20–0.71) for ≥7 cups/d, compared with nondrinkers. A similar inverse association was observed for MI survivors, but not evident for those without a history of stroke or MI. Coffee consumption was inversely associated with all-cause mortality in persons without a history of stroke or MI; the multivariable hazard ratios (95% CIs) were 0.86 (0.82–0.91) for 1 to 6 cups/wk, 0.86 (0.80–0.92) for 1 cup/d, and 0.82 (0.77–0.89) for ≥2 cups/d, compared with nondrinkers. The corresponding hazard ratios (95% CIs) for MI survivors were 0.69 (0.53–0.91), 0.78 (0.55–1.10), and 0.61 (0.41–0.90). No such association was observed for stroke survivors.

Conclusions:
Green tea consumption can be beneficial in improving the prognosis for stroke or MI survivors, whereas coffee consumption can also be so for persons without a history of stroke or MI as well as MI survivors.
Ultra-Early Cerebral Thrombosis Formation After Experimental Subarachnoid Hemorrhage Detected on T2* Magnetic Resonance Imaging
Authors: Wang Zhepei , Chen Jingyin , Toyota Yasunori , Keep Richard F. , Xi Guohua , Hua Ya 
Published: February 2021

Background and Purpose:
The mechanisms of brain damage during ultra-early subarachnoid hemorrhage (SAH) have not been well studied. The current study examined the SAH-induced hyperacute brain damage at 4 hours using magnetic resonance imaging and brain histology in a mouse model.

Methods:
SAH was induced by endovascular perforation in adult mice. First, adult male wild-type mice underwent magnetic resonance imaging T2 and T2* 4 hours after an endovascular perforation or a sham operation and were euthanized to assess brain histology. Second, male and female adult lipocalin-2 knockout mice had SAH. All animals underwent magnetic resonance imaging at 4 hours, and the brains were harvested for brain histology.

Results:
T2* hypointensity vessels were observed in the brain 4 hours after SAH in male wild-type mice. The numbers of T2*-positive vessels were significantly higher in SAH brains than in sham-operated mice. Brain histology showed thrombosis and erythrocyte plugs in the T2*-positive cerebral vessels which may be venules. The number of T2*-positive vessels correlated with SAH grade and the presence of T2 lesions. Brain thrombosis was also accompanied by albumin leakage and neuronal injury. LCN2 deficient male mice had lower numbers of T2*-positive vessels after SAH compared with wild-type male mice.

Conclusions:
SAH causes ultra-early brain vessel thrombosis that can be detected by T2* gradient-echo sequence at 4 hours after SAH. LCN2 deficiency decreased the number of T2*-positive vessels.
Integrated Stroke System Model Expands Availability of Endovascular Therapy While Maintaining Quality Outcomes
Authors: Lopez-Rivera Victor , Salazar-Marioni Sergio , Abdelkhaleq Rania , Savitz Sean I. , Czap Alexandra L. , Alderazi Yazan J. , Chen Peng R. , Grotta James C. , Blackburn Spiros L. , Jones Wesley , Spiegel Gary , Dannenbaum Mark J. , Wu Tzu-Ching , Cochran Joseph , Kim Dong H. , Day Arthur L. , Farquhar Grace , McCullough Louise D. , Sheth Sunil A. 
Published: February 2021

Background and Purpose:
The optimal endovascular stroke therapy (EVT) care delivery structure is unknown. Here, we present our experience in creating an integrated stroke system (ISS) to expand EVT availability throughout our region while maintaining hospital and physician quality standards.

Methods:
We identified all consecutive patients with large vessel occlusion acute ischemic stroke treated with EVT from January 2014 to February 2019 in our health care system. In October 2017, we implemented the ISS, in which 3 additional hospitals (4 total) became EVT-performing hospitals (EPHs) and physicians were rotated between all centers. The cohort was divided by time into pre-ISS and post-ISS, and the primary outcome was time from stroke onset to EPH arrival. Secondary outcomes included hospital and procedural quality metrics. We performed an external validation using data from the Southeast Texas Regional Advisory Council.

Results:

Among 513 patients with large vessel occlusion acute ischemic stroke treated with EVT, 58% were treated pre-ISS and 43% post-ISS. Over the study period, EVT procedural volume increased overall but remained relatively low at the 3 new EPHs (<70 EVT/y). After ISS, the proportion of patients who underwent interhospital transfer decreased (46% versus 37%;
P
<0.05). In adjusted quantile regression, ISS implementation resulted in a reduction of time from stroke onset to EPH arrival by 40 minutes (
P
<0.01) and onset to groin puncture by 29 minutes (
P
<0.05). Rates of postprocedural hemorrhage, modified Thrombolysis in Cerebral Infarction (TICI) 2b/3, and 90-day modified Rankin Scale were comparable at the higher and lower volume EPHs. The improvement in onset-to-arrival time was not reflective of overall improvement in secular trends in regional prehospital care.

Conclusions:
In our system, increasing EVT availability decreased time from stroke onset to EPH arrival. The ISS provides a framework to maintain quality in lower volume hospitals.
On the Connection Between Language Control and Executive Control—An ERP Study
Authors: Declerck Mathieu , Meade Gabriela , Midgley Katherine J. , Holcomb Phillip J. , Roelofs Ardi , Emmorey Karen 
Published: February 2021

Abstract
Models vary in the extent to which language control processes are domain general. Those that posit that language control is at least partially domain general insist on an overlap between language control and executive control at the goal level. To further probe whether or not language control is domain general, we conducted the first event-related potential (ERP) study that directly compares language-switch costs, as an index of language control, and task-switch costs, as an index of executive control. The language switching and task switching methodologies were identical, except that the former required switching between languages (English or Spanish) whereas the latter required switching between tasks (color naming or category naming). This design allowed us to directly compare control processes at the goal level (cue-locked ERPs) and at the task performance level (picture-locked ERPs). We found no significant differences in the switch-related cue-locked and picture-locked ERP patterns across the language and task switching paradigms. These results support models of domain-general language control.
Carnet De Route D’un Voyageur Congolais: Masala à L’exposition Universelle D’anvers, en 1885.
Authors: Etambala Zana Aziza 
Published: February 2021

Notebook of a Congolese Traveller: Masala at the 1885 Antwerp World Exhibition
Masala, the central figure in this article, came to Belgium to be exhibited, together with eleven other natives of the Congo Independent State, at the International Fancy Fair organized in Antwerp in 1885. Of course, the illiterate Masala didn’t take notes during his stay in Antwerp. But a meticulous investigation of the contemporary local press, which paid enough attention to this event, made it possible to describe in detail the daily european experiences of Masala and his companions. It also enables us to examine the ‘white’ belgian view on the black subjects of Leopold II.
Between ‘Anti-totalitarianism’ and Radical Democracy
Authors: Taşçıoğlu Irem 
Published: February 2021

Abstract
Laclau’s theory on populism which is inseparable from his strategic endeavour to formulate a novel form of left-wing emancipatory politics has set off a variety of critiques, most notably from scholars who associate themselves with different strands of democratic theory. This paper picks out and uses Lefortian theory on democracy, utilizing it in order to figure out the different ways in which Laclau’s account could be construed and criticized. It argues that there are two possible interpretations of Lefort’s democratic theory with two different political implications, one liberal and the other radical-democratic and that they provide us with two different ways to formulate a critique of Laclauian populism. It particularly addresses the historical conjuncture from which Lefort’s democratic theory emerges and investigates how his ambiguous encounters with the intellectual milieu in France in the 70s, namely the ‘antitotalitarian moment’ undergird these two possible interpretations. This article’s elaboration on these two interpretations for addressing Laclau’s populism finalizes with a comparison between the political implications of the two and with a new proposal to invigorate counter-populism along the lines of Etienne Balibar as a (Lefortian) radical-democratic alternative to Laclau’s populism.
Middle-Atmosphere Temperature Monitoring Addressed with a Constellation of CubeSats Dedicated to Climate Issues
Authors: Keckhut Philippe , Hauchecorne Alain , Meftah Mustapha , Khaykin Sergey , Claud Chantal , Simoneau Pierre 
Published: February 2021

AbstractWhile meteorological numerical models extend upward to the mesopause, mesospheric observations are required for leading simulations and numerical weather forecasts and climate projections. This work reviews some of the challenges about temperature observation requirements and the limiting factors of the actual measurements associated with atmospheric tides. A new strategy is described here using a limb-scattering technique that is based on previous experiments in space. Such observations can be used with cube satellites. Technical issues are the large dynamic range (4 orders of magnitude) required for the measurements, the accuracy of the limb pointing, and the level of stray light. The technique described here will expect accuracy of 1–2 K with a vertical resolution of 1–2 km. A constellation of 100 platforms could provide temperature observations with space (100 km) and time (3 h) resolutions recommended by the World Meteorological Organization, and tidal issues could be resolved with a minimum of 3–5 platforms with specific orbit maintained to avoid drifts.
Mobile Ka-Band Polarimetric Doppler Radar Observations of Wildfire Smoke Plumes
Authors: Aydell Taylor B. , Clements Craig B. 
Published: February 2021

ABSTRACTRemote sensing techniques have been used to study and track wildfire smoke plume structure and evolution; however, knowledge gaps remain because of the limited availability of observational datasets aimed at understanding fine-scale fire–atmosphere interactions and plume microphysics. Meteorological radars have been used to investigate the evolution of plume rise in time and space, but highly resolved plume observations are limited. In this study, we present a new mobile millimeter-wave (Ka band) Doppler radar system acquired to sample the fine-scale kinematics and microphysical properties of active wildfire smoke plumes from both wildfires and large prescribed fires. Four field deployments were conducted in autumn of 2019 during two wildfires in California and one prescribed burn in Utah. Radar parameters investigated in this study include reflectivity, radial velocity, Doppler spectrum width, differential reflectivity ZDR, and copolarized correlation coefficient ρHV. Observed radar reflectivity ranged between −15 and 20 dBZ in plume, and radial velocity ranged from 0 to 16 m s−1. Dual-polarimetric observations revealed that scattering sources within wildfire plumes are primarily nonspherical and oblate-shaped targets as indicated by ZDR values measuring above 0 and ρHV values below 0.8 within the plume. Doppler spectrum width maxima were located near the updraft core region and were associated with radar reflectivity maxima.
Effects of the full-scale substitution of strontium for calcium on the microstructure of brushite: (CaxSr1–x)HPO4.nH2O system
Authors: Alshaaer Mazen , Afify Ahmed S. , Moustapha Moustapha E. , Hamad Nagat , Hammouda Gehan A. , Rocha Fernando 
Published: February 2021

AbstractBrushite (CaHPO4.2H2O) is an important calcium phosphate encountered in bone tissue engineering and bone cement formulation. There are many studies on the synthesis and characterization of brushite, but full-scale substitution and replacement of Ca by Sr in brushite as a key element in medical and environmental applications has not yet been explored systematically. Therefore, this study aims to evaluate the effects of substitution of Ca by Sr on the microstructural and thermal properties of brushite, including the chemical phases present, crystallization, structural water and phase stability. The chemical phases were determined by means of powder X-ray diffraction. The thermal properties were studied by thermogravimetric analysis. Crystallization and surface morphology were analysed using scanning electron microscopy. Various properties were dependent on the incorporated Sr ions. The replacement percentage of Sr may be divided into two major stages: the first from 0% to 50%; and the second from 50% up to 100%. The (CaxSr1–x)HPO4.nH2O shows that micro-scale crystals of platy brushite formed in the first stage of Sr replacement, from 0% up to 50%. As Sr might inhibit the formation of crystals, crystal nucleation rates were reduced as the Sr percentage increased. An amorphous product formed as a result of 50% Sr replacement. The second stage of Sr replacement with Sr contents >50% yielded a new crystal morphology corresponding mainly to SrHPO4.nH2O. The complete replacement of Ca by Sr transforms the brushite with platy microcrystals into SrHPO4 nanosheets.
Denosumab compared with zoledronic acid on PFS in multiple myeloma: exploratory results of an international phase 3 study
Authors: Terpos Evangelos , Raje Noopur , Croucher Peter , Garcia-Sanz Ramon , Leleu Xavier , Pasteiner Waltraud , Wang Yang , Glennane Anthony , Canon Jude , Pawlyn Charlotte 
Published: February 2021

Abstract
An exploratory end point from a recent trial in patients with newly diagnosed multiple myeloma showed that median progression-free survival (PFS) was increased by 10.7 months with denosumab vs zoledronic acid. We performed additional analyses to identify factors that may have contributed to the favorable PFS with denosumab. Ad hoc analyses were performed for patients intending to undergo autologous stem cell transplantation (ASCT; ASCT intent), not intending to undergo ASCT (ASCT no intent), and intent-to-treat according to age (&lt;70 or ≥70 years) and baseline renal function (≤60 mL/min or &gt;60 mL/min creatinine clearance [CrCl]). Of 1718 patients, 930 (54.1%) were in the ASCT-intent subgroup, and 788 (45.9%) were in the ASCT-no-intent subgroup. In the ASCT-intent subgroup, frontline triplet (median PFS, not estimable vs 35.7 months; hazard ratio [HR] [95% confidence interval (CI)], 0.65 [0.47-0.90]; descriptive P = .009) or bortezomib-only (median PFS, not estimable vs not estimable; HR [95% CI], 0.61 [0.39–0.95]; descriptive P = .029) induction regimens demonstrated the strongest PFS benefit favoring denosumab vs zoledronic acid. In the ASCT-no-intent subgroup, no benefit with denosumab vs zoledronic acid was observed. PFS favored denosumab vs zoledronic acid in patients with CrCl &gt;60 mL/min and in patients &lt;70 years old, but no difference was observed in patients with CrCl ≤60 mL/min or patients ≥70 years old. The PFS difference observed with denosumab is one of the notable benefits reported in newly diagnosed multiple myeloma and was most pronounced in patients intending to undergo ASCT and those who received proteasome inhibitor (PI)−based triplet regimens. This study was registered at www.clinicaltrials.gov as #NCT01345019.
Antileukemic efficacy of a potent artemisinin combined with sorafenib and venetoclax
Authors: Moses Blake S. , McCullough Samantha , Fox Jennifer M. , Mott Bryan T. , Bentzen Søren M. , Kim MinJung , Tyner Jeffrey W. , Lapidus Rena G. , Emadi Ashkan , Rudek Michelle A. , Kingsbury Tami J. , Civin Curt I. 
Published: February 2021

AbstractArtemisinins are active against human leukemia cell lines and have low clinical toxicity in worldwide use as antimalarials. Because multiagent combination regimens are necessary to cure fully evolved leukemias, we sought to leverage our previous finding that artemisinin analogs synergize with kinase inhibitors, including sorafenib (SOR), by identifying additional synergistic antileukemic drugs with low toxicity. Screening of a targeted antineoplastic drug library revealed that B-cell lymphoma 2 (BCL2) inhibitors synergize with artemisinins, and validation assays confirmed that the selective BCL2 inhibitor, venetoclax (VEN), synergized with artemisinin analogs to inhibit growth and induce apoptotic cell death of multiple acute leukemia cell lines in vitro. An oral 3-drug “SAV” regimen (SOR plus the potent artemisinin-derived trioxane diphenylphosphate 838 dimeric analog [ART838] plus VEN) killed leukemia cell lines and primary cells in vitro. Leukemia cells cultured in ART838 had decreased induced myeloid leukemia cell differentiation protein (MCL1) levels and increased levels of DNA damage–inducible transcript 3 (DDIT3; GADD153) messenger RNA and its encoded CCATT/enhancer-binding protein homologous protein (CHOP), a key component of the integrated stress response. Thus, synergy of the SAV combination may involve combined targeting of MCL1 and BCL2 via discrete, tolerable mechanisms, and cellular levels of MCL1 and DDIT3/CHOP may serve as biomarkers for action of artemisinins and SAV. Finally, SAV treatment was tolerable and resulted in deep responses with extended survival in 2 acute myeloid leukemia (AML) cell line xenograft models, both harboring a mixed lineage leukemia gene rearrangement and an FMS-like receptor tyrosine kinase-3 internal tandem duplication, and inhibited growth in 2 AML primagraft models.