bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zanubrutinib for the treatment of Bing–Neel syndrome
Authors: Sarosiek Shayna , Ramirez‐Gamero Andres , Flynn Catherine A. , Treon Steven P. , Castillo Jorge J. 
Published: February 2025

SummaryInfiltration of the central nervous system by malignant lymphoplasmacytic cells is a rare complication of Waldenström macroglobulinaemia (WM) and is referred to as Bing–Neel syndrome (BNS). Traditionally, the treatment of BNS included chemotherapy, but in more recent years, the oral Bruton tyrosine kinase (BTK) inhibitor ibrutinib has become a standard therapy for WM and the most common therapy for BNS due to the drugs tolerability and ability to cross the blood–brain barrier. Zanubrutinib, a second‐generation covalent BTK inhibitor with fewer off‐target effects, is also effective in WM. In this series, we report on the successful use of zanubrutinib in nine patients with BNS, of whom five had prior exposure to ibrutinib and four were naïve to BTK inhibitors.
Featured Cover
Authors: Meißgeier Tina , Kappelmann‐Fenzl Melanie , Staebler Sebastian , Ahari Ata Jadid , Mertes Christian , Gagneur Julien , Linck‐Paulus Lisa , Bosserhoff Anja Katrin 
Published: February 2025

The cover image is based on the article Splicing control by PHF5A is crucial for melanoma cell survival by Anja Katrin Bosserhoff et al., https://doi.org/10.1111/cpr.13741.
image
A “data‐for‐decisions” management system to facilitate cost‐efficiency in conservation interventions
Authors: Guerrero‐Pineda Camila , Gerber Leah R. , Sangolquí Paola , Chafla Javier , Iacona Gwenllian D. 
Published: February 2025

AbstractConservation practice is chronically hindered by scarce financial resources. Thus, understanding the relationship between the costs and outcomes of conservation interventions is critical to efficiently maximize conservation benefits. Data on the costs of conservation interventions are necessary for such analyses but are rarely reported at the appropriate scale. To support managers in deciding how to invest in a way that maximizes conservation outcomes, we developed a data management structure that allows managers to pair expenditure records with measurements of intervention outcomes, following a theory of change. To overcome the common issues that conservation scientists and practitioners face when estimating costs and guide the accumulation of data that is appropriate for decision support, we present a new data management system that guides users in incorporating cost data. We demonstrate the application of our approach by applying the data management structure within the red spiny lobster fishery in the Galápagos Marine Reserve. We implement the structure in an Excel workbook that tracks the costs and outcomes of actions prescribed by the theory of change. By synthesizing data in a consistent manner across different interventions, our results help conservation managers to identify ways to minimize cost, justify budgets, and compare strategies over time to make better decisions. Our “data‐for‐decisions” management system enables the conservation community to efficiently use knowledge of past experiences to inform future decisions that can maximize conservation benefits.
Too Risky for Businesses?—Examining the Relationship Between Crime and Firm Registrations in India
Authors: Biswas Shreya , Jain Ritika 
Published: February 2025

ABSTRACTThe study examines the relationship between crime and firm entry in India. Using district‐level data for a decade, we find that an increase in crime is related to fewer firms registering in the district. The results are robust to estimation approaches that address the endogeneity related to crime variable. We also explore the pathways through which crime negatively affects firm entry in India. We provide suggestive evidence in favour of a fall in demand caused by the lower income of existing firms in the market as one of the reasons why crime lowers firm entry. Additionally, we show that fear of victimisation is also a possible channel that drives the negative relationship between crime and firm entry. However, we do not find any evidence that crime increases the expenses incurred by existing firms. The findings have important policy implications in terms of the importance of a stable environment for firm entry.
First Report of Bacteria Associated With Bleeding Cankers on Oak Trees in Serbia
Authors: Tkaczyk Miłosz , Sikora Katarzyna , Milenković Ivan 
Published: February 2025

ABSTRACTThe aim of this study was to confirm the presence of bacteria that are partly responsible for the oak dieback phenomenon, known as Acute Oak Decline, in Serbia. Seventeen symptomatic oak trees (both Quercus robur and Quercus cerris) were sampled in April 2024 and analysed using multiplex real‐time PCR. Brenneria goodwinii was detected in one tree from Morović, whereas Gibbsiella quercinecans was found in two trees from Morović and Progar. This is the first report of these bacteria in Serbia, despite bioclimatic models predicting a low likelihood of their presence in the Balkans. Our results indicate the presence of oak dieback bacteria in areas where they have not yet been reported, highlighting the need for increased research and awareness of bacterial diseases in forest trees.
A Latent Profile Analysis of Psychosis Symptoms to Examine Distress and Depression as Pathways to Suicide Ideation Among Individuals in an Early Phase of Psychosis Illness
Authors: Bornheimer Lindsay A. , Brdar Nicholas M. , Lapidos Adrienne , Kelter Alexandra N. , Miner Chloe , Grogan‐Kaylor Andrew 
Published: February 2025

ABSTRACTBackgroundSuicide rates are high among individuals in first episode psychosis and there is a critical need to better understand drivers of suicide risk to inform treatment efforts. This study identified profiles of psychosis symptoms and examined a mediation model of depression and distress as mechanisms in the relationships between psychosis symptoms and suicide ideation by latent profiles.MethodsData were obtained from the Human Connectome Project for Early Psychosis (n = 166) of individuals between 16 and 35 years of age who had onset of affective or non‐affective psychosis within 5 years of consent. Data were analysed using Latent Profile Analysis (LPA) and Structural Equation Modelling in MPlus.ResultsLPA revealed the following groups: (1) relatively lower and more balanced levels of symptoms, (2) highest positive and general symptoms and (3) highest negative symptoms. Findings indicated the relationships in the model differed between by LPA groups. Distress and depression functioned as mediators between psychosis symptoms and suicide ideation for Groups 1 and 2.ConclusionsA better understanding of the roles that distress and depression play in the relationships between psychosis symptoms and suicide ideation can help inform modifiable targets of early intervention and subsequently decrease risk for suicide.
Crop Rotation With Ley and Nitrogen Fertilisation Reduced Soil Carbon Loss in Three Swedish Long‐Term Field Experiments
Authors: Lang Rong , Bolinder Martin A. , Börjesson Gunnar , Kätterer Thomas 
Published: February 2025

ABSTRACTIncreasing soil organic carbon (SOC) stocks by improving cropland management practices has great potential to mitigate climate change. Long‐term field experiments (LTEs) are valuable to study management effects on soil properties and crop yield. Yet most LTE studies are limited to the topsoil, and farming systems integrating multiple management strategies are often not assessed. This study used three Swedish LTEs to assess the effects of crop rotations and fertilisation on SOC changes. One arable rotation with only annual crops and a ley rotation with annuals, perennial ley and receiving manure were investigated at different application rates of mineral fertilisers. We analysed changes in SOC content and the distribution of SOC content and stocks at multiple soil depths, calculated C inputs and used phospholipid fatty acids (PLFAs) to evaluate how management practices affected SOC in relation to C inputs and microbial communities. Both systems lost carbon in the 0–20 cm topsoil from 1966 to 2019 across sites, but the sandy site lost more than the clayey sites. The ley rotation and nitrogen (N) fertilisation reduced carbon losses. In 2019, SOC stocks in the top 25 cm soil were 3.3 ± 1.6 Mg C ha−1 higher in the ley rotation compared with arable rotation and 2.9 ± 1.6 Mg C ha−1 higher with N fertilisation at the highest rate compared with no N fertilisation. However, the positive effects decreased with depth and became negative at some depths. As a result, differences in SOC stocks to an equivalent depth of 60 cm declined to 0.6 ± 2.4 Mg C ha−1 for rotations and to 1.0 ± 2.4 Mg C ha−1 for N fertilisation. The ley rotation had significantly higher belowground C inputs than the arable rotation, and belowground C inputs were highly associated with changes in SOC. Compared with the arable rotation, total PLFAs, bacterial PLFAs and the ratio of bacteria to fungi in topsoil were significantly higher in the ley rotation, partly attributed to manure application. Our study supports the beneficial effects of leys and manure amendments on SOC compared with systems with only annual crops. It also highlights the risk of losing SOC in the subsoil, especially under mineral N fertilisation. Site characteristics helped to explain the large variation, which must be considered when developing local strategies for SOC accrual in cropland.
Demographic Characteristics and Parenthood Across Three Cohorts of Sexual Minority Adults
Authors: Simon Kay A. , Meslay Gaëlle , Farr Rachel H. , Russell Stephen T. 
Published: February 2025

ABSTRACTAs measurement of sexual minority (SM) people's demographic characteristics has evolved over time, it is of interest to understand how identity intersections within SM communities, such as SM parents, have also changed. The current study aimed to investigate how SM parents may or may not differ in demographic characteristics from SM childfree adults and how the demographic characteristics of SM parents may differ across three cohorts. Participants could be part of one of three age cohorts, with each cohort reflecting distinct historic or cultural events related to LGBTQ+ people's experiences. We used data from a national probability study of 1502 SM adults conducted between 2016 and 2017 to compare demographic characteristics by parent and cohort status. SM parents (n = 297) and childfree adults differed in sexual and gender identity, relationship status, educational attainment, urbanicity, and poverty status. There were differences among SM parents based on cohort status in sexual and gender identity, partner status (and gender of the partner), educational attainment, poverty status, and urbanicity. However, there were no differences based on racial/ethnic identity or geographic region among SM parents. This work contributes to the ongoing literature on SM parent families by providing a view of the ways in which SM parents have, and have not, changed demographically over time in the United States.
Host Species–Microbiome Interactions Contribute to Sphagnum Moss Growth Acclimation to Warming
Authors: Živković Tatjana , Carrell Alyssa A. , Granath Gustaf , Shaw A. Jonathan , Pelletier Dale A. , Schadt Christopher W. , Klingeman Dawn M. , Nilsson Mats B. , Helbig Manuel , Warshan Denis , Klarenberg Ingeborg J. , Gilbert Daniel , Kostka Joel E. , Weston David J. 
Published: February 2025

ABSTRACTSphagnum moss is the dominant plant genus in northern peatlands responsible for long‐term carbon accumulation. Sphagnum hosts diverse microbial communities (microbiomes), and its phytobiome (plant host + constituent microbiome + environment) plays a key role in nutrient acquisition along with carbon cycling. Climate change can modify the Sphagnum‐associated microbiome, resulting in enhanced host growth and thermal acclimation as previously shown in warming experiments. However, the extent of microbiome benefits to the host and the influence of host–microbe specificity on Sphagnum thermal acclimation remain unclear. Here, we extracted Sphagnum microbiomes from five donor species of four peatland warming experiments across a latitudinal gradient and applied those microbiomes to three germ‐free Sphagnum species grown across a range of temperatures in the laboratory. Using this experimental system, we test if Sphagnum's growth response to warming depends on the donor and/or recipient host species, and we determine how the microbiome's growth conditions in the field affect Sphagnum host growth across a range of temperatures in the laboratory. After 4 weeks, we found that the highest growth rate of recipient Sphagnum was observed in treatments of matched host–microbiome pairs, with rates approximately 50% and 250% higher in comparison to maximum growth rates of non‐matched host–microbiome pairs and germ‐free Sphagnum, respectively. We also found that the maximum growth rate of host–microbiome pairs was reached when treatment temperatures were close to the microbiome's native temperatures. Our study shows that Sphagnum's growth acclimation to temperature is partially controlled by its constituent microbiome. Strong Sphagnum host–microbiome species specificity indicates the existence of underlying, unknown physiological mechanisms that may drive Sphagnum's ability to acclimatize to elevated temperatures. Together with rapid acclimation of the microbiome to warming, these specific microbiome–plant associations have the potential to enhance peatland resilience in the face of climate change.
Supermarketisation, Agro‐Industrial Concentration and the Food System's Shrinking Interstices: Insights From South African Agro‐Processing
Authors: Bowman Andrew 
Published: February 2025

ABSTRACTWe analyse processes of supermarketisation in South Africa and its implications for inclusion, exclusion and industrial concentration in the mid‐sections of agri‐food value chains. Empirical material from maize processing shows differentiated impacts accompanying major retailers’ growing power and extended reach into the food system's township and rural peripheries. Large firms’ co‐evolutionary adaptations and constitutive power counteract supermarket buyer power. Smaller firms struggle with adverse incorporation in supermarket supply chains, relying instead on strategies targeting independent wholesale and the informal retail economy. However, this carries major risks, requires complex capabilities and is increasingly threatened by market delocalisation accompanying supermarketisation. Contrary to expectations of retail modernisation enabling inclusive agri‐food value chain development by connecting marginalised rural producers to larger urban markets, we highlight the potential for inverse processes whereby ‘peripheral supermarketisation’ extends the reach of large firms in rural markets and shrinks the ‘interstices’ incubating small agri‐food producers.
Mastering the formulation of an unstable vitamin C (VC) as anti‐aging skin care ingredient. Part I: A new approach
Authors: Isoir‐Ingrez Muriel , Falip Anne , Yousfi Naima , Arnaud‐Sebillotte Laurence , Biatry Bruno , Leroy Florence , Wang Pamella H. , Simonnet Jean‐Thierry 
Published: February 2025

AbstractObjectiveTo develop a stabilized 12% pure Vitamin C‐based serum at a pH close to that of the skin for use in anti‐aging.Material and MethodsAt acidic pH (<3), under oxidative conditions, the ascorbate anionic form of VC rapidly undergoes transformations leading to a Xylosone by‐product, resulting in important chemical losses of VC. Buffering the ascorbate anionic moiety with alkaline agents largely decreases its transformation and the loss of VC. The use of a cationic polymer (Polyquaternium 67, PQ67) enables binding of the ascorbate anion by creating an ionic network, at pH 6 and slows down the slight yellowing of the serum.ResultsBy exposing this complex to a temperature of 45°C for a two‐month period, more acceptable degradation was obtained, with less VC chemical loss (approx. 5%–10%). Although a slight yellowish colour developed, it was found non redhibitory through consumer tests. As a result, such combination still leaves an important concentration of pure VC (over 10%) likely able to express its efficacy as anti‐aging ingredient. Further refinements of this association were performed to reach adequate organoleptic properties of the formula, in view of a future clinical test, as proof of performance of VC efficacy at pH 6.ConclusionThe stabilized formulation of VC at a pH close to that of the skin, apt at being tested in vivo, offers new possibilities for skin anti‐aging routines strategy, by avoiding too acidic conditions (∼pH 3 or below) in daily use cosmetics and thereby allowing better tolerance and an increased adherence of the consumers.
The Adoption of Green Technologies in Indonesia: Shrimp Farmers' Facebook Group as an Online Community of Practice
Authors: Pratiwi Ayu , Lee Guenwoo , Farikhah  , Kettunen Erja 
Published: February 2025

ABSTRACTThis study contributes to literature on learning pathways and agricultural innovation diffusion by exploring the use of a virtual platform on the adoption of green technologies in a global South context. The case depicts online learning within a significant food system in Southeast Asia, Indonesian shrimp farming, and focuses on the dissemination of innovation within an online group. Based on a data set of 1059 shrimp farmers, we investigate the effects of membership in the Indonesian Vannamei Shrimp Communities (KUVI), a prominent Online Community of Practice (OCoP) on Facebook. We compare the adoption of green technologies between KUVI members and non‐members, and focus on how learning takes place in KUVI and how it influences technology adoption by shrimp farmers engaged in traditional extensive farming characterized by low stock density and minimal infrastructure, and those involved in more advanced intensive farming with higher stock densities and more advanced infrastructure. We find that KUVI members expanded their information sources on shrimp cultivation and significantly gained new information compared to non‐members, leading to the adoption of green technologies that address a major farming issue namely the prevention of shrimp disease. Since information in KUVI is codified rather than tacit, we also find differences between the two types of farming: KUVI members in extensive farming adopted context‐dependent technologies to cope with climate issues, while intensive farmers' environmentally friendly practices were more precise and strongly related to shrimp quality and productivity. The results indicate that not all agricultural information can be effectively disseminated using virtual platforms, as users have different cognitive capacities to absorb the information. Thus some practices still require experience and tacit knowledge from physical peers to be properly implemented.
Stream Co‐Occurrence Networks Depend on Spatial Extent, Environmental Conditions and Organismal Group
Authors: Budnick William R. , Mruzek Joseph L. , Larson Chad A. , Leboucher Thibault , Passy Sophia I. 
Published: February 2025

ABSTRACTAimCo‐occurrence networks can be described in terms of topology (i.e., size and connectance) and node degree distribution (NDD). The NDD represents the frequency distribution of nodes (species) with k number of connections (degree). The shape of the NDD, single‐scale, scale‐free (power‐law) or broad‐scale, reveals if there are species with many connections to other species (high‐degree nodes), which may have important ecological functions. However, it remains unknown how spatial extent and environmental conditions impact network topology and the NDD shape and whether these relationships depend on species dispersal capacity.LocationContinental United States of America.TaxaStream diatoms and fish.MethodsWe constructed landscape windows ranging in spatial extent from 160,000 to 2,560,000 km2. For each window, we calculated environmental heterogeneity and median environmental conditions and generated correlation‐based co‐occurrence networks. We evaluated the topology and NDD shape of each network. To each NDD, we fit six statistical models, classified as single‐scale, power‐law or broad‐scale. Contingency table analysis, redundancy analyses and variance partitioning tested the sources of variability in network topology and/or NDD shape.ResultsThe NDDs were almost exclusively fit either by single‐scale + broad‐scale models or broad‐scale models. As spatial extent increased, network size increased, connectance decreased, and the NDD shifted in an organism‐specific manner. In both groups, network responses to spatial extent were attributed primarily to variability in climatic heterogeneity followed by urban development in diatoms.Main ConclusionsSpatial extent determined co‐occurrence network properties primarily via climatic and land use factors. Broad‐scale NDDs, indicating the presence of high‐degree nodes, were more common in the well‐dispersed diatoms than in the more poorly dispersing fish. Furthermore, these NDDs increased in frequency with spatial extent and climatic heterogeneity in diatoms but decreased in fish. High‐degree nodes are likely climatic generalists in diatoms but keystone or more dispersive species in fish.
The Innovative Roles of Supply Chain Finance Platforms in Generating Competitive Advantage
Authors: Wang Chenyu , Wang Wei , Li Shuting , Chen Xiangfeng 
Published: February 2025

ABSTRACTSupply chain finance (SCF) platforms have become increasingly important in providing financial services within supply chains. However, their role in creating competitive advantage is not well understood. This paper presents findings from an in‐depth multiple‐case study of four representative SCF service‐providing platforms in China, aiming to examine why firms build SCF platforms, the innovative strategies firms adopt to develop SCF solutions, and the impact of these solutions on their business models and their competitive advantage. Data were collected through multiple interviews. The research findings suggest that the value disciplines of SCF platforms evolve through different stages in response to changes in customer needs. This evolution progresses from pursuing product and service leadership to operational excellence and, lastly, to customer intimacy. This study also identifies the various financial products and services provided by these SCF platforms at each stage. It then further points out the direction of creating ecosystem value as the ultimate goal of the SCF platforms. This study enhances the understanding of the innovative roles of SCF platforms and their impact on the development of new business models and gaining a competitive advantage based on value disciplines.