bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post‐transplant maintenance therapy in patients with FLT3‐mutated acute myeloid leukemia: Real‐world treatment patterns and outcomes
Authors: Griffin James D. , Song Yan , Yang Hongbo , Freimark Jonathan , Shah Manasee V. 
Published: July 2021

AbstractObjectivesMaintenance therapy is one strategy to prolong survival in patients with acute myeloid leukemia (AML) following hematopoietic stem cell transplantation (HSCT). We evaluated real‐world treatment patterns and outcomes in patients with newly diagnosed FLT3‐mutated AML receiving HSCT after complete remission with first‐line chemotherapy.MethodsA global, retrospective chart review to evaluate maintenance therapy and outcomes in patients with FLT3‐mutated AML after HSCT.ResultsData from 1208 charts from eight countries showed that most patients (n = 765 [63.3%]) received no maintenance therapy after HSCT, 219 (18.1%) received FLT3 inhibitor maintenance therapy, and 224 (18.5%) received other types of maintenance therapy. No systematic differences were observed in healthcare resource utilization across the three groups. Clinical benefit was observed with FLT3 inhibitor maintenance over no maintenance therapy with relapse‐free survival (adjusted hazard ratio [HR] 0.57 [95% CI 0.34‐0.94], P < .05). FLT3 inhibitor and other maintenance also demonstrated overall survival benefit over no maintenance (adjusted HR 0.50 [95% CI 0.28‐0.89] and 0.46 [95% CI 0.23‐0.91], respectively; both P < .05).ConclusionsReal‐world maintenance therapies after HSCT in patients with FLT3‐mutated AML were heterogeneous. While overall use of healthcare resources was not significantly increased in patients receiving maintenance therapy versus those who did not, clinical outcomes were improved.
Presidential power and stock returns
Authors: Kim Youngsoo , Park Jung Chul 
Published: July 2021

AbstractRecent studies highlight the positive effect of political connections on firm performance and stock returns. This paper shows that the positive effect of political connections on stock returns becomes substantially weaker in the weak presidency period, defined as the last 2 years before presidential party change or period of low job approval ratings. We consider two hypotheses—political interconnectedness and political risk—and find that both hypotheses are important in explaining the weak presidency effect on stock returns, political benefits, and research and development and capital expenditure. There is a trade‐off between direct political investment and passive political alignment. Firms with direct political investment tend to hedge political risk so that they can run their real side investment on their own schedule. Consistent with this story, we find that the weak presidency effect is more pronounced for small firms that lack the resources for direct political investment.
Location choice and spatial distribution of the electronic information manufacturing industry in China
Authors: Chen Xiaofei , Wang Enru , Guo Jianfeng , Miao Changhong 
Published: July 2021

AbstractThis paper examines the changing spatial distribution of electronic information manufacturing (EIM) industry in China by focusing on the location choice of new firms. A three‐pronged “global‐regional‐local” nexus framework was proposed to identify the factors that influence firm location choice. Tobit regression analysis was performed to evaluate the impacts of these factors. The study reveals the spatial concentration of the EIM industry and a trend of westward diffusion. The regression analyses stratified by time period and by region demonstrate spatial and temporal variabilities in the influence of many factors, especially the regional advantage factors (e.g., labor cost, localization economies, and urbanization economies). Meanwhile, some factors, such as foreign direct investment, the presence of state‐owned enterprises, and local government policies, show stable effects over time and across regions.
Bringing the imperial back in: Reconsidering governance in the late Ottoman Empire, 1839–1923 (Part II)
Authors: Kuehn Thomas 
Published: July 2021

AbstractThis is the second of two connected articles that survey recent trends in the historical scholarship of Ottoman imperial governance from the beginning of the Tanzimat state building efforts in the 1830s to the end of empire in the early 1920s. In both articles, I examine how historians have answered the question of what was imperial about the ways in which the Ottoman Empire was governed during this period. Throughout this two‐part series, I argue that an approach that pays attention to the capacity to govern, as Jane Burbank and Frederick Cooper put it, “different people differently” through a broad repertoire of rule balancing this politics of difference with the politics of incorporation, is more conducive to bringing out the complexities of late Ottoman governance than teleological assumptions that consider the empire during this period on a linear path towards the nation state. Part I demonstrated that starting from the 1990s, scholarship on the empire's peripheries in Transjordan, Mount Lebanon, Yemen, and Albania was instrumental in reframing the study of late Ottoman governance by taking its imperial dimensions seriously. In Part II, I will continue this line of inquiry by reviewing pioneering studies that located the politics of difference and incorporation across the empire and not just in its peripheral regions. Here, I will also discuss a body of innovative scholarship that uses the analytical lenses of governmentality, techno‐politics, and International Law to shed light on the novel material, logistical, and legal capacities developed by the Ottoman state especially during the Hamidian period. In the final section, I will turn to studies that suggest that practices of Ottoman imperial governance remained relevant for the running of some of the empire's successor states.
Infants born preterm and infants born full‐term generate more selective leg joint movement during the scaffolded mobile task
Authors: Kim Jeong Ah , Fetters Linda , Kubo Masayoshi , Havens Kathryn L. , Eckel Sandrah P. , Sargent Barbara 
Published: July 2021

AbstractInfants born very preterm (PT), prior to 32 weeks gestation, are at increased risk of developing cerebral palsy. Children with spastic cerebral palsy have impaired selective leg joint movement, which contributes to lifelong walking limitations. We investigated whether infants born PT generated more selective hip–knee joint movement (e.g., hip flexes as knee extends) while participating in a scaffolded mobile task. Infants born PT and infants born full‐term (FT) at 4 months corrected age participated in a scaffolded mobile task for 2–3 consecutive days. The scaffolded mobile task required infants to raise their legs vertically over a virtual threshold. Three threshold heights (low, middle, and high) were used to test whether the middle and high heights encourage infants to move their legs more selectively. Fifteen infants born FT learned the task and showed more selective hip–knee movement at each of the three threshold heights on the day that they learned, compared with their baseline spontaneous kicking. Thirteen infants born PT learned the task and showed more selective hip–knee movement on their learning day, but only when the middle and high thresholds were used. The results show that the scaffolded mobile task effectively encouraged infants to generate more selective hip–knee joint movement.
Contract choice for upstream innovation in a finance‐constrained supply chain
Authors: Xing Guangyuan , Xia Bing , Guo Jue 
Published: July 2021

AbstractThis study explores a supply chain with one finance‐constrained upstream startup supplier that invests in quality innovation and one downstream manufacturer that sells to consumers under demand uncertainty. The survival and profit‐seeking cases are investigated for the startup supplier. The manufacturer supports quality innovation by the startup supplier via an investment‐sharing contract. The results show that when making quality investment decisions, the survival‐seeking supplier focuses on financial constraints, whereby large constraints pressure the firm to invest more in quality innovation. By contrast, profit‐seeking suppliers are encouraged by a large potential market. Investment‐sharing contracts are proven to facilitate "win‐win" vertical R&D cooperation in the supply chain. Last, by introducing a revenue‐sharing contract and comparing it with an investment‐sharing contract, our numerical analyses show how the manufacturer should select the appropriate contract as key parameters change.
Nurse‐Family Partnership nurses’ attitudes and confidence in identifying and responding to intimate partner violence: An explanatory sequential mixed methods evaluation
Authors: Jack Susan M. , Kimber Melissa , Davidov Danielle , Ford‐Gilboe Marilyn , Wathen C. Nadine , McKee Christine , Tanaka Masako , Boyle Michael , Johnston Carolyn , Coben Jeffrey , Gasbarro Mariarosa , McNaughton Diane , O’Brien Ruth , Olds David L. , Scribano Philip , MacMillan Harriet L. 
Published: July 2021

AbstractAimsTo evaluate the effect of an intimate partner violence intervention education component on nurses’ attitudes in addressing intimate partner violence; complementary aims included understanding nurses’ perceptions of the education and how it influenced their attitudes and confidence to address intimate partner violence in practice.DesignAn explanatory sequential mixed methods design embedded within a 15‐site cluster randomized clinical trial that evaluated an intimate partner violence intervention within the Nurse‐Family Partnership programme.MethodsData were collected between February 2011 and September 2016. Quantitative assessment of nurses’ attitudes about addressing intimate partner violence was completed by nurses in the intervention (n = 77) and control groups (n = 101) at baseline, 12 months and at study closure using the Public Health Nurses’ Responses to Women Who Are Abused Scale. Qualitative data were collected from nurses in the intervention group at two timepoints (n = 14 focus groups) and focused on their perceptions of the education component. Data were analysed using content analysis.ResultsNurses in the intervention group reported large improvements in their thoughts, feelings and perceived behaviours related to addressing intimate partner violence; a strong effect of the education was found from baseline to 12 months and baseline to study closure timepoints. Nurses reported that the education component was acceptable and increased their confidence to address intimate partner violence.ConclusionNurses reported improved attitudes about and confidence in addressing intimate partner violence after receiving the education component. However, these findings need to be considered together with trial results showing no main effects for clients, and a low level of intervention fidelity.ImpactThese evaluation findings underscore that improvement in nurses’ self‐reported educational outcomes about addressing intimate partner violence cannot be assumed to result in adherence to intervention implementation or improvement in client outcomes. These are important considerations for developing nurse education on intimate partner violence.
Impact of home blood pressure variability on cardiovascular outcome in patients with arterial stiffness: Results of the J‐HOP study
Authors: Ishiyama Yusuke , Hoshide Satoshi , Kanegae Hiroshi , Kario Kazuomi 
Published: July 2021

AbstractThis study sought to investigate whether the relation between increased blood pressure (BP) variability and increased arterial stiffness confers a risk for cardiovascular disease (CVD) events. We analyzed 2648 patients from a practitioner‐based population (mean ± SD age 64.9 ± 11.4 years: 75.8% taking antihypertensive medication) with at least one cardiovascular risk factor who underwent home BP monitoring in the Japan Morning Surge‐Home Blood Pressure Study. The standard deviation (SDSBP), coefficient of variation (CVSBP), and average real variability (ARVSBP) were assessed as indexes of day‐by‐day home systolic BP (SBP) variability. The authors assessed arterial stiffness by brachial‐ankle pulse wave velocity (baPWV) and divided patients into lower (< 1800 cm/s, n = 1837) and higher (≥1800 cm/s, n = 811) baPWV groups. During a mean follow‐up of 4.4 years, 95 cardiovascular events occurred (8.1 per 1000 person‐years). In Cox proportional hazard models adjusted for traditional cardiovascular risk factors including average home SBP, the highest quartiles of SDSBP (hazard ratio [HR], 2.30; 95% confidence interval [CI], 1.23‐4.32), CVSBP (HR, 2.89; 95%CI, 1.59‐5.26) and ARVSBP (HR, 2.55; 95%CI, 1.37‐4.75) were predictive of CVD events compared to the other quartiles in the higher baPWV group. Moreover, 1SD increases in SDSBP (HR, 1.44; 95%CI, 1.13‐1.82), CVSBP (HR, 1.49; 95%CI, 1.16‐1.90) and ARVSBP (HR, 1.37; 95%CI, 1.09‐1.73) were also predictive of CVD events. These associations remained even after N‐terminal pro‐brain natriuretic peptide was added to the models. However, these associations were not observed in the lower baPWV group. We conclude that arterial stiffness contributes to the association between home BP variability and CVD incidence.
Mitochondrial DNA haplogroup M7 confers a reduced risk of colorectal cancer in a Han population from northern China
Authors: Yuan Qing , Su Liping , Wang Tian , Liu Yang , Lu Zhenxing , Zhou Kaixiang , Guo Shanshan , Gu Xiwen , Xing Jinliang , Guo Xu 
Published: July 2021

AbstractMitochondria are central eukaryotic organelles in cellular metabolism and ATP production. Mitochondrial DNA (mtDNA) alterations have been implicated in the development of colorectal cancer (CRC). However, there are few reports on the association between mtDNA haplogroups or single nucleotide polymorphisms (SNPs) and the risk of CRC. The mtDNA of 286 Northern Han Chinese CRC patients were sequenced by next‐generation sequencing technology. MtDNA data from 811 Han Chinese population controls were collected from two public data sets. Then, logistic regression analysis was used to determine the effect of mtDNA haplogroup or SNP on the risk of CRC. We found that patients with haplogroup M7 exhibited a reduced risk of CRC when compared to patients with other haplogroups (odds ratio [OR] = 0.532, 95% confidence interval [CI] = 0.285–0.937, p = 0.036) or haplogroup B (OR = 0.477, 95% CI = 0.238–0.916, p = 0.030). Furthermore, haplogroup M7 was still associated with the risk of CRC when the validation and combined control cohort were used. In addition, several haplogroup M7 specific SNPs, including 199T>C, 4071C>T and 6455C>T, were significantly associated with the risk of CRC. Our results indicate the risk potential of mtDNA haplogroup M7 and SNPs in CRC in Northern China.
Drought stress and plant ecotype drive microbiome recruitment in switchgrass rhizosheath
Authors: Liu Tie‐Yuan , Ye Nenghui , Wang Xinyu , Das Debatosh , Tan Yuxiang , You Xiangkai , Long Mingxiu , Hu Tianming , Dai Lei , Zhang Jianhua , Chen Mo‐Xian 
Published: July 2021

AbstractThe rhizosheath, a layer of soil grains that adheres firmly to roots, is beneficial for plant growth and adaptation to drought environments. Switchgrass is a perennial C4 grass which can form contact rhizosheath under drought conditions. In this study, we characterized the microbiomes of four different rhizocompartments of two switchgrass ecotypes (Alamo and Kanlow) grown under drought or well‐watered conditions via 16S ribosomal RNA amplicon sequencing. These four rhizocompartments, the bulk soil, rhizosheath soil, rhizoplane, and root endosphere, harbored both distinct and overlapping microbial communities. The root compartments (rhizoplane and root endosphere) displayed low‐complexity communities dominated by Proteobacteria and Firmicutes. Compared to bulk soil, Cyanobacteria and Bacteroidetes were selectively enriched, while Proteobacteria and Firmicutes were selectively depleted, in rhizosheath soil. Taxa from Proteobacteria or Firmicutes were specifically selected in Alamo or Kanlow rhizosheath soil. Following drought stress, Citrobacter and Acinetobacter were further enriched in rhizosheath soil, suggesting that rhizosheath microbiome assembly is driven by drought stress. Additionally, the ecotype‐specific recruitment of rhizosheath microbiome reveals their differences in drought stress responses. Collectively, these results shed light on rhizosheath microbiome recruitment in switchgrass and lay the foundation for the improvement of drought tolerance in switchgrass by regulating the rhizosheath microbiome.
An extensive record of orogenesis recorded in a Madagascar granulite
Authors: Horton Forrest , Holder Robert M. , Swindle Carl R. 
Published: July 2021

AbstractWe present a comprehensive petrological and geochronological study of a single granulite sample from the lithosphere‐scale Beraketa shear zone in southern Madagascar to constrain the orogenic history of Gondwana assembly in this region. The studied sample provides a panoply of data constraining the prograde, retrograde, and late metasomatic history of the region via the application of Ti‐in‐quartz, Ti‐in‐zircon, Zr‐in‐rutile, and Al‐in‐orthopyroxene thermobarometry; phase‐equilibrium modelling; U–Pb monazite, zircon, and rutile petrochronology; and trace element diffusion chronometry in rutile. Our results reveal five stages of metamorphism along a narrow clockwise P–T path that may have begun as early as 620–600 Ma and certainly by 580–560 Ma, based on the oldest concordant zircon dates. The rock was heated to >725°C at less than 7.5 kbar (Stage 1) before burial to ~8 kbar (Stage 2). By c. 540 Ma, the rock had heated to ~970°C at ~9 kbar, and lost approximately 12% melt (Stage 3), before decompressing and cooling to the solidus at ~860°C and 6.5 kbar within 10 Ma (Stage 4). The vast majority of monazite and zircon dates record Stage 4 cooling and exhumation. Monazite and zircon rim dates as young as c. 510 Ma record subsolidus cooling (Stage 5) and associated symplectite formation around garnet. U–Pb rutile dates record partial resetting at c. 460 Ma; Zr‐ and Nb‐in‐rutile diffusion chronometry link these dates to a metasomatic event that lasted <1 Ma at ~600°C. In addition to chronicling a near‐complete cycle of metamorphism in southern Madagascar, this study constrains the rates of heating and cooling. We estimate that heating (7–14°C/Ma) outpaced reasonable radiogenic heating rates with modest mantle heat conduction. Therefore, we conclude that elevated mantle heat conduction or injection of mantle‐derived magmas likely contributed to regional ultrahigh‐temperature metamorphism (UHTM). Exhumation and cooling from peak metamorphic conditions to the solidus occurred at rates greater than 0.45 km/Ma and 14°C/Ma.
Evidence that increased cholecystokinin (CCK) in the periaqueductal gray (PAG) facilitates changes in Resident–Intruder social interactions triggered by peripheral nerve injury
Authors: Keay Kevin A. , Argueta Manuel A. , Zafir Daniel N. , Wyllie Peter. M. , Michael Gregory J. , Boorman Damien C. 
Published: July 2021

AbstractIndividual differences in the effects of a chronic neuropathic injury on social behaviours characterize both the human experience and pre‐clinical animal models. The impacts of these changes to the well‐being of the individual are often underappreciated. Earlier work from our laboratory using GeneChip® microarrays identified increased cholecystokinin (CCK) gene expression in the periaqueductal gray (PAG) of rats that showed persistent changes in social interactions during a Resident–Intruder encounter following sciatic nerve chronic constriction injury (CCI). In this study, we confirmed these gene regulation patterns using RT‐PCR and identified the anatomical location of the CCK‐mRNA as well as the translated CCK peptides in the midbrains of rats with a CCI. We found that rats with persistent CCI‐induced changes in social behaviours had increased CCK‐mRNA in neurons of the ventrolateral PAG and dorsal raphe nuclei, as well as increased CCK‐8 peptide expression in terminal boutons located in the lateral and ventrolateral PAG. The functional significance of these changes was explored by microinjecting small volumes of CCK‐8 into the PAG of uninjured rats and observing their Resident–Intruder social interactions. Disturbances to social interactions identical to those observed in CCI rats were evoked when injection sites were located in the rostral lateral and ventrolateral PAG. We suggest that CCI‐induced changes in CCK expression in these PAG regions contributes to the disruptions to social behaviours experienced by a subset of individuals with neuropathic injury.
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Using the SRSD Instructional Approach for Argumentative Writing: A Look across the Content Areas
Authors: Peltier Corey , Garwood Justin D. , McKenna John , Peltier Tiffany , Sendra Jesse 
Published: July 2021

AbstractThis article will discuss ways to use self‐regulated strategy development for argumentative writing across content areas. The goal of self‐regulated strategy development is for students to generalize the use of the strategy across settings, allowing them to become fluent and proficient writers in all areas. In addition, the generalization of the strategy across settings increases maintenance of skills across time. We will provide steps for educators to use the self‐regulated strategy development instructional approach—more commonly used in reading, writing, and mathematics—across science and social studies content areas with key illustrations using new mnemonics from current practitioners.
Target of rapamycin controls hyphal growth and pathogenicity through FoTIP4 in Fusarium oxysporum
Authors: Li Linxuan , Zhu Tingting , Song Yun , Luo Xiumei , Datla Raju , Ren Maozhi 
Published: July 2021

AbstractFusarium oxysporum is the causal agent of the devastating Fusarium wilt by invading and colonizing the vascular system in various plants, resulting in substantial economic losses worldwide. Target of rapamycin (TOR) is a central regulator that controls intracellular metabolism, cell growth, and stress responses in eukaryotes, but little is known about TOR signalling in F. oxysporum. In this study, we identified conserved FoTOR signalling pathway components including FoTORC1 and FoTORC2. Pharmacological assays showed that F. oxysporum is hypersensitive to rapamycin in the presence of FoFKBP12 while the deletion mutant strain ΔFofkbp12 is insensitive to rapamycin. Transcriptomic data indicated that FoTOR signalling controls multiple metabolic processes including ribosome biogenesis and cell wall‐degrading enzymes (CWDEs). Genetic analysis revealed that FoTOR1 interacting protein 4 (FoTIP4) acts as a new component of FoTOR signalling to regulate hyphal growth and pathogenicity of F. oxysporum. Importantly, transcript levels of genes associated with ribosome biogenesis and CWDEs were dramatically downregulated in the ΔFotip4 mutant strain. Electrophoretic mobility shift assays showed that FoTIP4 can bind to the promoters of ribosome biogenesis‐ and CWDE‐related genes to positively regulate the expression of these genes. These results suggest that FoTOR signalling plays central roles in regulating hyphal growth and pathogenicity of F. oxysporum and provide new insights into FoTOR1 as a target for controlling and preventing Fusarium wilt in plants.