bluuebunny/crossref_metadata_2025_split huggingface dataset:
miR-17~92 Promotes Progression of ABC-DLBCL Lymphoma via Regulation of Canonical NF-kB Signaling
Authors: Wang Xianhuo , Wang Huaqing , Zhang Xiaoyan , Bi Chengfeng , McKeithan Timothy W. , Huang Xin , Meng Bin , Chan Wing C. , Vose Julie M. , Zhang Huilai , Fu Kai 
Published: July 2021

Abstract
Background: Activated B-cell like diffuse large B-cell lymphoma (ABC-DLBCL) is an aggressive lymphoma characterized by constitutive NF-κB activation. Nevertheless, the role and mechanisms of miR-17~92 in contributing to the NF-κB activation in ABC-DLBCL are still elusive. Methods: The expression of miR-17~92 primary transcript (MIR17HG) and NF-κB target genes was determined using RNA-sequencing. The expression of miR-17~92 was performed using microarray analysis. Plasmids carrying conditional over-expression and loss-of-function of miR-17~92 were respectively constructed and dual-luciferase reporter assay was used to validate the target gene of miR-17~92. Immunoprecipitation and polyubiquitination were further used to the study of potential mechanisms.Results: Expression of MIR17HG was positively correlated with NF-κB activity, miR-17~92 activated the NF-κB signaling in ABC-DLBCL, and its over-expression promoted ABC-DLBCL cell growth, accelerated cell G1 to S phase transition and enhanced cell resistance to NF-κB inhibitor. Importantly, miR-17~92 promoted NF-κB activation through directly targeting multiple ubiquitin-editing regulators to lead to increase the K63-linked polyubiquitination and decrease the K48-linked polyubiquitination of RIP1 complex in ABC-DLBCL. We further found that miR-17~92 selectively activated IκB-α and NF-κB p65 but not NF-κB p52/p100, and high miR-17~92 expression was also associated with poorer outcome in ABC-DLBCL patients. Conclusions: Taken together, miR-17~92 selectively activate the canonical NF-κB signaling via targeting ubiquitin-editing regulators to lead to constitutively NF-κB activation and poorer outcome, which is an innovative function of miR-17~92 and previously unappreciated regulatory mechanism of NF-κB activation in ABC-DLBCL. Targeting miR-17~92 may thus provide a novel bio-therapeutic strategy for ABC-DLBCL patients.
Differential Performance of Neutrophil Gelatinase-Associated Lipocalin and Cystatin C to Predict Ischemic Stroke
Authors: Peng Ling , Chen Xiaohong , Fu Yanhong , Yang Yuwei , Feng Jiafu 
Published: July 2021

Abstract
Objective Both cystatin C (CysC) and neutrophil gelatinase-associated lipocalin (NGAL) are markers of kidney injury and may also be marker candidates for neuroinflammation. The aim of this article is to explore the relationship between kidney injury and ischemic stroke (IS).Methods 498 IS patients were enrolled, and 173 IS-related disease control (DC) patients and 293 healthy control (HC) subjects were randomly selected. We analyzed the relationship between the levels of serum kidney function markers (including NGAL, Cre, Ure, CysC and eGFR) and the occurrence of IS.Results When they were admitted to the hospital, the NGAL level of patients with first-onset IS was higher than that of both HC group (z=5.964, P<0.001) and DC (z=12.191, P<0.001); The level of CysC of them was higher than that of HC group (z=5.762, P<0.001), and was the similar with that of DC group (z=1.663, P=0.289). The partial correlation coefficient between NGAL and the occurrence of IS was the highest (rp=0.341, P<0.001) in IS patients with normal kidney function. However, the partial correlation coefficient between CysC and IS was the highest (rp=0.460) , P<0.001) in IS patients with chronic kidney disease (CKD). For patients with normal kidney function, only NGAL was a risk factor for IS [OR(95%CI)=6.54(3.75,11.41)], and had the certain predictive performance AUC=0.734(z=12.928, P<0.001). However, for CKD patients, CysC has better predictive performance for IS occurrence AUC=0.835 (z=11.343, P<0.001) and risk assessment ability [OR(95%CI)=5.97(2.45, 14.56)] than NGAL.Conclusion IS is related to kidney injury and neuroinflammation. NGAL and CysC are suitable for IS prediction in patients with normal kidney function and CKD, respectively. Researchers should pay attention to the changes of NGAL and CysC for the prevention and treatment of stroke in these two types of patients, respectively.
Dynamic Analysis and Cryptographic Application of a Sinusoidal-polynomial Composite Chaotic System
Authors: Zhu Hegui , Ge Jiangxia , Qi Wentao , Zhang Xiangde , Lu Xiaoxiong 
Published: July 2021

Abstract
Owning to complex properties of ergodicity, non-periodic ability and sensitivity to initial states, chaotic systems are widely used in cryptography. In this paper, we propose a sinusoidal--polynomial composite chaotic system (SPCCS), and prove that it satisfies Devaney's definition of chaos: the sensitivity to initial conditions, topological transitivity and density of periodic points. The experimental results show that the SPCCS has better unpredictability and more complex chaotic behavior than the classical chaotic maps. Furthermore, we provide a new image encryption algorithm combining pixel segmentation operation, block chaotic matrix confusing operation, and pixel diffusion operation with the SPCCS. Detailed simulation results verify effectiveness of the proposed image encryption algorithm.
A case of severe open bite malocclusion with crowding and short roots treated by two-jaw surgery including four-piece LeFort I osteotomy
Authors: Hoshijima Mitsuhiro , Oka Naoki , Matsumura Tatsushi , Iida Seiji , Kamioka Hiroshi 
Published: July 2021

Abstract
BackgroundAppropriate operations in severe anterior open bite (AOB) cases are extremely complicated to perform because of the multiple surgical procedures involved, difficulty of predicting posttreatment aesthetics and high relapse rate.Case reportWe herein report a 16-year-old girl with skeletal Class II, severe AOB malocclusion and crowding with short roots and aesthetic and functional problems. Four-piece segmental LeFort I osteotomy combined with a posterior horseshoe-like osteotomy was performed for maxillary intrusion, and sagittal split ramus osteotomy (SSRO) and genioplasty were performed for mandibular advancement. The malocclusion and skeletal deformity were significantly improved by the surgical orthodontic treatment. Functional and aesthetic occlusion with an improved facial profile was established, and no further root shortening was observed. Acceptable occlusion and dentition were maintained after a two-year retention period.ConclusionThis strategy of surgical orthodontic treatment with a complicated operative procedure might be effective for managing severe AOB malocclusion.
Outcomes of Multiple Gestation Births Compared to Singleton: Analysis of Multicenter KID Database
Authors: Thekkeveedu Renjithkumar Kalikkot , Dankhara Nilesh , Desai Jagdish , Klar Angelle L , Patel Jaimin M 
Published: July 2021

Abstract
BackgroundThe available data regarding morbidity and mortality associated with multiple gestation births is also conflicting and contradictingObjectiveTo compare morbidity, mortality, and length of stay (LOS) outcomes between multiple gestation (twin, triplet and higher-order) and singleton births.Methods Data from national multicenter Kids’ Inpatient Database of the Healthcare Cost and Utilization Project from the years 2000, 2003, 2006, 2009, 2012, and 2016 were analyzed using complex survey design using SAS. Neonates with ICD9 and ICD10 codes indicating singletons, twins or triplets, and higher-order multiples were included. Mortality was compared between these groups after excluding transfer outs to avoid duplicate inclusion. To analyze LOS, we included inborn neonates, and excluded transfers and who died inpatient and any neonates who appear to have been discharged less than 33 weeks PMA. The LOS was compared by gestational age groups. ResultsA total of 22,853,125 neonates were analyzed for mortality after inclusion-exclusion; 2.96% were twins, and 0.13% were triplets or more. A total of 22,690,082 neonates were analyzed for LOS. Mean GA, expressed as mean (SD), for singleton, twins and triplets were 38.30(2.21), 36.39 (4.21), and 32.72(4.14), respectively. The adjusted odds for mortality were similar for twin births compared to singleton (aOR: 1.004, 95% CI:0.960-1.051, p=0.8521). The adjusted odds of mortality for triplet or higher-order gestation births were higher (aOR: 1.33, 95% CI: 1.128-1.575, p =0.0008) as compared to singleton. Median LOS (in days) was significantly longer in multiple gestation compared to singleton overall (Singletons: 1.59 [1.13, 2.19] vs twins 3.29 [2.17, 9.59] vs triplets or higher order multiples 19.15 [8.80, 36.38], p <.0001), and this difference remained significant within each GA category. ConclusionMultiple gestation births have higher mortality and longer LOS when compared to singleton births. This population data from multiple centers across the country could be useful in counseling parents when caring for multiple gestation pregnancies.
An Open-Label Single-Arm Clinical Trial of Propranolol Cream in Infantile Hemangioma
Authors: Nagata Eiko , Kashiwagura Yasuharu , Okada Eisaku , Tanaka Shimako , Sano Shinichiro , Nishida Mitsuhiro , Hayano Satoshi , Iwashima Satoru , Hakamata Akio , Odagiri Keiichi , Inui Naoki , Watanabe Hiroshi , Umemura Kazuo , Uchida Shinya 
Published: July 2021

Abstract
Infantile hemangioma (IH) is a common tumor in infants that gradually resolves and is often followed up for observation. However, for cosmetic reasons, parents often opt for treatment. Oral propranolol, the first-line therapy for IH, shows several side effects, including hypotension, bradycardia, and hypoglycemia. No clinical studies on topical propranolol have been conducted using standardized procedures. We evaluated the efficacy and safety of topical propranolol in patients with IH. This multicenter, open-label phase II study was conducted from June 2019 to December 2020 and involved 8 Japanese infants aged 35–150 days with proliferating IH. Patients were treated with 5% propranolol cream twice daily. We examined the efficacy rate based on central evaluation (complete or near-complete healing of the target hemangioma) at weeks 24 and 12, respectively, compared to baseline values. The efficacy rate at week 24 was 68.8% (95% confidence interval: 44.1–85.9%). The surface area, maximum diameter, and color intensity of the target IH decreased over time. Adverse event and drug-related adverse event rates were 87.5% and 0%, respectively. Propranolol cream (5%) is effective and safe in Japanese patients with IH and may be considered a first-choice treatment for small and superficial IHs in cosmetically problematic areas.Trial registration numberThe trial is registered at the Japan Registry of Clinical Trials (jRCTs 041190041).Full date of first registration: 11/06/2019Web link: https://jrct.niph.go.jp/en-latest-detail/jRCTs041190041
A Study of Prevalence and Factors Associated with Geriatric Impairment: Evidence from a Cross-Sectional Study in India
Authors: Kumar Shubham , Chauhan Shekhar , Patel Ratna , Simon David Jean 
Published: July 2021

Abstract
Background: Increasing life expectancy and declining fertility, resulting from improved healthcare systems worldwide, has resulted in a growing elderly population. The paradigm shift of the population towards the aged has tremendous health implications. Therefore, this study intends to examine the five domains of geriatric impairment: physical, cognitive, hearing, vision, and speech impairment. Methods: The prevalence and factors associated with geriatric impairment were examined in this study by utilizing Longitudinal Ageing Study in India (LASI) wave-I data. Bivariate and binary logistic regression analyses were used as study tools. Results: The study has demonstrated that higher age had a gradient of negative impact on the older adults, although for the unadjusted model. Results found that female elderly (OR=0.81; C.I.= 0.68-0.97) and educated elderly likely (OR=0.57; C.I.= 0.32-1.02) were less likely to report geriatric impairment than their respective counterparts. Conclusion: There is a need to building partnerships to develop effective programs tackling impairment among the elderly. Launching programs that provide education for older adults to elicit potential health benefits may reduce impairment progression.
Vector-GMA: A New Easy Method for Analyzing Morphometric Data
Authors: Kopylov Dmitry S. 
Published: July 2021

Abstract
The new method of geometric morphometric analysis, called Vector-GMA is proposed. Unlike the classic TPS-based GMA, the new method allows considering missing and inapplicable landmarks and analyzing articulated structures. It also contains a set of tools for analyzing particular morphological features and searching for promising identification characters. The results of the analysis can be easily converted into phylogenetic matrix and analyzed with phylogenetic software. For the case study, the fore wings of all Cretaceous ichneumonids are analyzed.
Cognitive dysfunction associated with COVID-19: a comprehensive neuropsychological study
Authors: Delgado-Alonso Cristina , Valles-Salgado Maria , Delgado-Álvarez Alfonso , Yus Miguel , Gómez-Ruiz Natividad , Jorquera Manuela , Polidura Carmen , Gil María José , Marcos Alberto , Matías-Guiu Jorge , Matias-Guiu Jordi A 
Published: July 2021

Abstract
Objective. Recent evidence suggests that patients suffering post-acute COVID syndrome frequently report cognitive complaints, but their characteristics and pathophysiology are unknown. This study aims to determine the characteristics of cognitive dysfunction in patients reporting cognitive complaints after COVID-19 and to evaluate the correlation between cognitive function and anxiety, depression, sleep, and olfactory function.Methods. Cross-sectional study involving 50 patients with COVID-19 reporting cognitive complaints 9.12±3.46 months after the acute infection. Patients were evaluated with a comprehensive neuropsychological protocol, and scales of fatigue, depression, anxiety, sleep and an olfactory test. Normative data and an age- and education matched healthy control group were used for comparison. Results. COVID-19 patients showed a diminished performance on several tests evaluating attention and executive function, with alterations in processing speed, divided attention, selective attention, visual vigilance, intrinsic alertness, working memory, and inhibition; episodic memory; and visuospatial processing. Cognitive performance was correlated with olfactory dysfunction and sleep quality, but not with anxiety or depression.Conclusions. Patients with COVID-19 reporting cognitive symptoms showed a reduced cognitive performance, especially in the attention-concentration and executive functioning, episodic memory, and visuospatial processing domains. Future studies are necessary to disentangle the specific mechanisms associated with COVID-19 cognitive dysfunction.
Study on the Responsion of Biochemical Composition of S. acuminatus Biomass during the Spray Drying Process
Authors: Zhang Haiyang , Gong Ting , Li Jing , Pan Bo , Hu Qiang , Duan Ming , Zhang Xuezhi 
Published: July 2021

Abstract
Spray drying is a very popular method for microalgal biomass drying, however, systematic research on the responsion of biochemical composition during the process of spray drying has not been addressed so far. This study investigated the influence of the inlet temperature and initial solid content on the biochemical composition of spray dried Scenedesmus acuminatus biomass. The fatty acid composition and contents of CHNS, lipid, carbohydrate, protein, starch and pigments were analysed to characterize the quality and bioactivity of dried product. Results showed that the moisture content of dried microalgal powder decreased with the increase of inlet temperature and initial solid content, and the lowest moisture content of 2.37% with a higher drying yield of 84% was achieved at the optimized inlet temperature of 220°C and initial solid content of 16%. The biochemical compositions of CHNS total lipids, carbohydrates, protein, starch and fatty acid were similar with those dried by freeze drying, and were barely altered during the process of spray drying. However, the pigment would be partly degraded as the inlet temperature increased, which could be alleviated by increasing the initial solid content of the microalgal suspension due to the protection of cell aggregates. Thermogravimetric analysis (TGA) further confirmed that spray drying didn’t affect the quality of proteins, lipids and carbohydrates, suggesting that spray-drying technique could be applied to S. acuminatus for the production of both biofuels and nutritional supplements. These results may serve as a reference for the selection of drying method, utilization of the nutritional components in S. acuminatus and selection of biochemical parameters for spray-drying performance evaluation.
Contrasting Effects of Plant-Soil Feedbacks on Growth and Morphology of Two Clonal Plants
Authors: Xue Wei , Huang Lin , Sheng Wei-Jia , Zhu Jia-Tao , Li Shu-Qi , Yu Fei-Hai 
Published: July 2021

Abstract
AimSoil abiotic and biotic conditions are often spatially variable, challenging plants with a heterogeneous environment consisting of favorable and unfavorable patches of soil. Many stoloniferous clonal plants can escape from unfavorable patches by elongating stolon internodes, but aggregate in favorable ones through shortening stolon internodes. However, whether these plants can use their stolons to respond to plant-soil feedbacks (PSFs) is largely unknown. MethodsIn the conditioning phase, we grew either Hydrocotyle vulgaris or Glechoma longituba clonal plants separately in mesocosms to condition bulk soil. In the feedback phase, we grew connected mother and daughter ramets of each species in soil inoculated with the unsterilized or sterilized soil conditioned by conspecifics. We grew the plants for 12 weeks and measured the growth of the mother and daughter ramets separately. ResultsThe daughter ramets of H. vulgaris produced more biomass but shorter stolon internodes when grown in soil with sterilized inocula than with unsterilized inocula. However, no difference was found between the daughter ramets of G. longituba grown in soil with unsterilized and sterilized inocula. For both species, no significant difference was found between the mother ramet or between the daughter ramets when the mother ramet was grown in soil with sterilized and unsterilized inocula. Conclusions﻿The daughter ramets rather than the mother ramet of H. vulgaris experienced negative biotic PSFs. However, PSF had no effects on the daughter or mother ramet of G. longituba. Moreover, physiological integration or plasticity in stolon internode lengths cannot help H. vulgaris alleviate the negative PSFs.
Breakdown Voltage Enhancement of Al0.1Ga0.9N channel HEMT With Recessed Floating Field Plate
Authors: Natarajan Ramkumar , Parthasarathy Eswaran 
Published: July 2021

Abstract
In this paper, electrical and microwave characteristics of Al0.1Ga0.9N channel HEMTs was reported. The device performance were evaluated for conventional gate, field plate gate, and recessed floating field plate with Silicon nitride (SiN)/Hafnium oxide (HfO2) passivation. The recessed floating field plate HEMT with gate length LG = 0.8 µm, gate to drain distance LGD = 1 µm, and HfO2(SiN) passivation HEMT reports peak drain current density (IDS) of 0.282(0.288) A/mm at VGS = 0V, three terminal off-state breakdown voltage (VBR) of 677 (617) V, 6.38 Ω.mm of ON-resistance (RON), transconductance (gm,max) of 93(95) mS/mm, and FT/FMAX of 11.4/49 (12/22) GHz. The HfO2 (SiN) passivation device demonstrated the Johnson figure of merit (JFoM)) of 7.71 (7.404) THz.V and FMAX x VBR product of 33.173 (13.574) THz.V. The high JFoM along with high FMAX x VBR indicates the potential of the ultrawide bandgap AlGaN HEMTs for future power switching and high-power microwave applications. The proposed device DC characteristics are validated with reported expeimental work, which shows similar IDS and 54% and and 31% improvement in breakdown voltage on comparisons with conventional HEMT.
High Plasma Llevels of Aβ1-42 Affect Monocytes and Macrophages via Biphasic Effects on Myeloid-Derived Suppressor Cells and Granulocyte-Monocyte Progenitors in Mouse Models of Alzheimer’s Disease
Authors: Li Chunrong , Liu Kangding , Zhu Jie , Zhu Feiqi 
Published: July 2021

Abstract
Backgroud: Microglia play a crucial role in the pathogenesis of Alzheimer’s disease (AD). Plasma Aβ1-42 levels significantly increase 15 years before the onset of dominantly inherited AD. The effects of high plasma levels of Aβ1-42 on monocytes and macrophages, the hematogenous counterparts of microglia, remain unclear. Methods: We investigated the effects of plasma Aβ1-42 on peripheral monocytes and macrophages in three animal models, including 7- and 11-month-old female APPswe/PS1dE9 (APP/PS1) transgenic (Tg) mice, wild-type (Wt) parabiotic with Tg (paWt(Wt-Tg)) mice, and Wt mice. Results: We found that high plasma levels of Aβ1-42, in younger (7-month) AD mice significantly decreased the amounts of pro-inflammatory macrophages, myeloid derived suppressor cells (MDSCs), granulocyte-monocyte progenitors (GMP), and the plasma levels of interleukin-6 (IL-6). In older (11-month) AD mice, high plasma levels of Aβ1-42 significantly increased the amounts of pro-inflammatory macrophages, MDSCs, GMPs, the plasma levels of IL-6 and TNF-α, and the brain infiltration of bone marrow-derived macrophages (BMDMs). However, high plasma levels of Aβ1-42 consistently increased the amounts of monocytes and the proliferation of bone marrow cells (BMCs) without affecting the phagocytic function of macrophages on Aβ1-42. Conclusion: The response of mouse AD model suggests that a high plasma level of Aβ1-42 affects monocytes and macrophages via its biphasic effects on MDSCs and GMPs. We suggest that intervening in the effects of plasma Aβ1-42 on monocytes and macrophages might offer a new therapeutic approach to AD.
Dynamic Analysis of Gear Pairs with the Effects of Stick-slip
Authors: Xun Chao , Dai He 
Published: July 2021

Abstract

A stick-slip dynamic model of a two-gear set is proposed. In this model, time-varying mesh stiffness, tooth separation, friction between the gear teeth surfaces and potential stick-slip are considered. Considering the contributions of the vibration velocity to the gear teeth sliding velocity, transition conditions between the stick state and slip state are revealed. Dynamic analysis shows that, when stick appears, the vibration amplitudes are dramatically increased, and tooth separation occurs. Additionally, stick also induces half-frequency components of the mesh frequency and causes chaos. Parametric studies show that heavy loads and rough tooth surfaces increase the probability of stick and increase the time of the stick state over a single mesh period. However, due to the complex nonlinearity, the existence of a certain relationship between the gear rotation speed and the stick time is not confirmed.