bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statin Use and Outcomes of Patients With Acute Ischemic Stroke Treated With Intravenous Thrombolysis: A Systematic Review and Meta-Analysis
Authors: Guo Yu , Guo Xinmei , Zhao Kai , Bao Qiangji , Yang Jincai , Yang Mingfei 
Published: September 2021

Background: The data on the relationship between statin use and clinical outcomes after intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) are in controversy.Objective: This systematic review and meta-analysis aimed to evaluate the safety and efficacy of statins administered prior to onset and during hospitalization in patients with AIS treated with IVT.Methods: We searched PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from inception until June 8, 2021. Comparative studies investigating statin effect on intracranial hemorrhage (ICH), functional outcomes, and mortality in adults with AIS treated with IVT were screened. Random-effect meta-analyses of odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were performed. The protocol was registered in PROSPERO (CRD42021254919).Results: Twenty-two observational studies were included, which involved 17,554 patients. The pooled estimates showed that pre-stroke statin use was associated with a higher likelihood of symptomatic ICH (OR 1.31; 95% CI 1.07–1.59; p = 0.008) and any ICH (OR 1.21; 95% CI 1.03–1.43; p = 0.02). However, the pre-stroke statin use was not significantly associated with the 3-month mortality, 3-month favorable functional outcome (FFO, modified Rankin Scale [mRS] score 0–1), and 3-month functional independence (FI; mRS score 0–2). However, in-hospital statin use was associated with a reduced risk of symptomatic ICH (OR 0.46; 95% CI 0.21–1.00; p = 0.045), any ICH (OR 0.51; 95% CI 0.27–0.98; p = 0.04), and 3-month mortality (OR 0.42; 95% CI 0.29–0.62; p &lt; 0.001) and an increased probability of 3-month FFO (OR 1.33; 95% CI 1.02–1.744; p = 0.04) and 3-month FI (OR 1.41; 95% C, 1.11–1.80; p = 0.005).Conclusions: The present systematic review and meta-analysis suggests that in-hospital statin use after IVT may be safe and may have a favorable impact on clinical outcomes, a finding not observed in studies restricted to patients with pre-stroke statin use.
Endoscopic Endonasal Surgical Strategy for Skull Base Chordomas Based on Tumor Growth Directions: Surgical Outcomes of 167 Patients During 3 Years
Authors: Bai Jiwei , Li Mingxuan , Xiong Yujia , Shen Yutao , Liu Chunhui , Zhao Peng , Cao Lei , Gui Songbai , Li Chuzhong , Zhang Yazhuo 
Published: September 2021

BackgroundSkull base chordomas (SBCs) are rare malignant bone tumors with dismal long-term local control. Endoscopic endonasal surgeries (EESs) are increasingly adopted to resect SBCs recently. Gross total resection (GTR) favors good outcomes. However, the SBCs often invade the skull base extensively and hide behind vital neurovascular structures; the tumors were challenging to remove entirely. To improve the GTR, we established a surgical strategy for EES according to the tumor growth directions.MethodsA total of 112 patients with SBCs from 2018 to 2019 were classified into the derivation group. We retrospectively analyzed their radiologic images and operation videos to find the accurate tumor locations. By doing so, we confirmed the tumor growth directions and established a surgical strategy. Fifty-five patients who were operated on in 2020 were regarded as the validation group, and we performed their operations following the surgical strategy to verify its value.ResultsIn the derivation group, 78.6% of SBCs invade the dorsum sellae and posterior clinoid process region. 62.5% and 69.6% of tumors extend to the left and right posterior spaces of cavernous ICA, respectively. 59.8% and 61.6% of tumors extend to the left and right posterior spaces of paraclival and lacerum ICA (pc-la ICA), respectively. 30.4% and 28.6% of tumors extended along the left and right petroclival fissures that extend toward the jugular foramen, respectively. 30.4% of tumors involved the foramen magnum and craniocervical junction region. The GTR was achieved in 60.8% of patients with primary SBCs in the derivation group. Based on the tumors’ growth pattern, pituitary transposition and posterior clinoidectomy techniques were adopted to resect tumors that hid behind cavernous ICA. Paraclival ICA transposition was used when the tumor invaded the posterior spaces of pc-la ICA. Lacerum fibrocartilage resection and eustachian tube transposition may be warranted to resect the tumors that extended to the jugular foramen. GTR was achieved in 75.0% of patients with primary SBCs in the validation group.ConclusionBesides the midline clival region, the SBCs frequently grow into the eight spaces mentioned above. The surgical strategy based on the growth pattern contributes to increasing the GTR rate.
Non-Mass Enhancements on DCE-MRI: Development and Validation of a Radiomics-Based Signature for Breast Cancer Diagnoses
Authors: Li Yan , Yang Zhenlu L. , Lv Wenzhi Z. , Qin Yanjin J. , Tang Caili L. , Yan Xu , Guo Yihao H. , Xia Liming M. , Ai Tao 
Published: September 2021

PurposeWe aimed to assess the additional value of a radiomics-based signature for distinguishing between benign and malignant non-mass enhancement lesions (NMEs) on dynamic contrast-enhanced breast magnetic resonance imaging (breast DCE-MRI).MethodsIn this retrospective study, 232 patients with 247 histopathologically confirmed NMEs (malignant: 191; benign: 56) were enrolled from December 2017 to October 2020 as a primary cohort to develop the discriminative models. Radiomic features were extracted from one post-contrast phase (around 90s after contrast injection) of breast DCE-MRI images. The least absolute shrinkage and selection operator (LASSO) regression model was adapted to select features and construct the radiomics-based signature. Based on clinical and routine MR features, radiomics features, and combined information, three discriminative models were built using multivariable logistic regression analyses. In addition, an independent cohort of 72 patients with 72 NMEs (malignant: 50; benign: 22) was collected from November 2020 to April 2021 for the validation of the three discriminative models. Finally, the combined model was assessed using nomogram and decision curve analyses.ResultsThe routine MR model with two selected features of the time-intensity curve (TIC) type and MR-reported axillary lymph node (ALN) status showed a high sensitivity of 0.942 (95%CI, 0.906 - 0.974) and low specificity of 0.589 (95%CI, 0.464 - 0.714). The radiomics model with six selected features was significantly correlated with malignancy (P&lt;0.001 for both primary and validation cohorts). Finally, the individual combined model, which contained factors including TIC types and radiomics signatures, showed good discrimination, with an acceptable sensitivity of 0.869 (95%CI, 0.816 to 0.916), improved specificity of 0.839 (95%CI, 0.750 to 0.929). The nomogram was applied to the validation cohort, reaching good discrimination, with a sensitivity of 0.820 (95%CI, 0.700 to 0.920), specificity of 0.864 (95%CI,0.682 to 1.000). The combined model was clinically helpful, as demonstrated by decision curve analysis.ConclusionsOur study added radiomics signatures into a conventional clinical model and developed a radiomics nomogram including radiomics signatures and TIC types. This radiomics model could be used to differentiate benign from malignant NMEs in patients with suspicious lesions on breast MRI.
Growth Hormone Overexpression Induces Hyperphagia and Intestinal Morphophysiological Adaptations to Improve Nutrient Uptake in Zebrafish
Authors: Meirelles Marcela G. , Nornberg Bruna F. , da Silveira Tony L. R. , Kütter Mateus T. , Castro Caroline G. , Ramirez Juan Rafael B. , Pedrosa Virgínia , Romano Luis Alberto , Marins Luis Fernando 
Published: September 2021

Graphical AbstractGH overexpression increases the intestinal mass and absorptive surface area both through the direct effects of GH transgenics (up-regulating the expression of its cognate receptor and insulin-like growth factor, igf1a) and through indirect effects through an increase in the amount of food consumed. In addition, hyperphagia provides a greater amount of nutrients in the intestinal lumen and stimulates the synthesis of di- and tri-peptide transporters, which are the main route of absorption of dietary products from protein degradation.
The Validity of the Holtzman Inkblot Technique: New Indices
Authors: Dawe James , Hawkins II Raymond C. , Lauriola Marco , Leichsenring Falk , Pezzuti Lina 
Published: September 2021

Objective: The present study examines the validity of 11 new Holtzman Inkblot Technique indices. These were chosen from Exner’s Comprehensive System (RCS) indices using two criteria: first, they had to be valid according to meta-analysis, and second, they must be computed using the HIT standard scoring system.Methods: Both techniques were administrated with a retest interval from 1 to 7days to a sample of 139 subjects (63 males and 76 females) from the general population. The validity of the new indices was studied through Pearson correlation (r) with the corresponding RCS indices.Results: Nine of the 11 new indices (R-HIT, F%-HIT, M-HIT, m-HIT, C'-HIT, Blends-HIT, PureH-HIT, DQ+HIT, and X-%-HIT) showed significant correlations with Rorschach scales, confirming our hypotheses. The correlation ranged from a minimum of 0.144 to a maximum of 0.414.Conclusions: The results provide support for the validity of the new HIT indices and have important implications for both clinical and research fields.
Clinical Correlates of Deliberate Self-Harm Among Migrant Trauma-Affected Subgroups
Authors: Baralla Francesca , Ventura Martina , Negay Nikolay , Di Napoli Anteo , Petrelli Alessio , Mirisola Concetta , Sarchiapone Marco 
Published: September 2021

Introduction: Studies have shown that exposure to potentially traumatic events (PTEs) during the migration process has serious consequences on mental health. Migrants with a history of PTEs are more likely to inflict deliberate self-harm (DSH), a spectrum of behavior that includes non-suicidal self-injury (NSSI). With reference to a nonclinical sample of trauma-exposed migrants, this study aims to explore the prevalence of DSH and to assess the association with sociodemographic characteristics and clinical conditions, with particular attention to post-traumatic stress disorder (PTSD) symptoms, resilience capabilities, and feelings of hopelessness.Methods: A sample of migrants underwent a baseline evaluation at an outpatient department of the National Institute for Health, Migration and Poverty (INMP). Migrants with a history of torture, rape, or other severe forms of psychological, physical, or sexual violence were invited to undergo screening at the Institute's Mental Health Unit. Trauma-exposed migrants completed a series of self-report questionnaires that assessed the presence of PTSD, depression, anxiety, suicidal ideation, resilience, and feelings of hopelessness, in addition to DSH. Univariate and multivariate log-binomial regression models were used to test the association of age and clinical characteristic of migrants with DSH. Prevalence ratio (PR) with 95% confidence intervals (95% CI) and p-values were estimated.Results: A total of 169 migrants (76.9% males), aged between 18 and 68 years, M = 28.93; SD = 8.77), were selected. Of the sample, 26.6% were frequently engaging in some form of DSH, and 30.2% were diagnosed with at least one trauma-related disorder. DSH behaviors were most common in single and unemployed migrants as well as in subjects with post-traumatic stress symptoms, feelings of anxiety, hopelessness, low capability of resilience, and suicidal ideation. Taking into account age and hopelessness, we found that PTSD and low resilience capabilities were associated with a higher risk of DSH [PR adj: 2.21; 95% CI: (1.30–3.75) and PR adj: 2.32; 95% CI: (1.16–4.62), respectively].Conclusion: Given the association between trauma exposure and DSH among migrants, exploring the presence of DSH behavior within the immigrant community is crucial for the implementation of measures to develop intervention in a clinical setting.
Clinical Value of TXNDC12 Combined With IDH and 1p19q as Biomarkers for Prognosis of Glioma
Authors: Wang Xinzhuang , Yang Quan , Liu Nan , Bian Qilong , Gao Ming , Hou Xu 
Published: September 2021

Background: Glioma is the primary malignant tumor of the central nervous system and presents high mortality and disability rates under existing treatment measures. Thioredoxin domain-containing 12 (TXNDC12) has been shown to play an important role in various malignant tumors. Therefore, we explored the clinicopathological characteristics of TXNDC12 in glioma to bring to light new ideas in its treatment.Methods: We obtained data packages related to TXNDC12 expression status in gliomas from public databases. We analyzed glioma TXNDC12 expression and patient survival status and validated the above results using glioma specimens from our institution. Next, we analyzed the value of TXNDC12 in combination with 1p19q and isocitrate dehydrogenase (IDH) on the prognosis of glioma by regression model and receiver operating characteristic curve (ROC). Finally, we explored the function of related genes by GO analysis and KEGG analysis.Results: Compared with normal brain tissue, the expression of TXNDC12 in glioma cells, regarding both mRNA and protein levels, was significantly upregulated. The survival time of patients with high-expression of TXNDC12 in glioma cells was shortened. In the World Health Organization pathological classification, IDH status, 1p19q status, and IDH combined with 1p19q subgroups, the expression of TXNDC12 increased with the deterioration of the above indicators. Tumor local immune analysis showed that the immune cell infiltration in TXNDC12 high-expressing glioma tissue increased, the tumor purity was reduced. GO and KEGG analyses indicated that TXNDC12 may be involved in the malignant prognosis of glioma through glycosylation and antigen processing and presentation.Conclusion: We showed that TXNDC12 is significantly highly expressed in gliomas. This high expression predicts the poor prognosis of glioma patients and is related to the gliomas’ local immune microenvironment. As a tumor-related gene, TXNDC12 may be used as a new prognostic judgment molecule.
Estudio de la fertilización química y orgánica y su efecto en el cultivo de Maíz (Zea mays.), en una comuna
Authors: Garcia Cabrera Juan Miguel , Castro Piguave Carlos Alberto , Moreno Mera Gaspar Martín 
Published: September 2021

Basado al manejo de diversos tipos de fertilizantes de origen orgánico como químico empleados en el cultivo de Maíz (Zea Mays), se propuso determinar las diferencias dadas en el desarrollo morfológico del cultivo; e identificar la mejor nutrición que permita obtener mayores niveles de productividad y que a su vez establecerá la relación costo-beneficio de los tratamientos establecidos. La metodología aplicada, permitió utilizar un modelo de bloques completamente al azar de cuatro repeticiones, los tratamientos basados en la fertilización fueron a partir de: Yara, Ecológico, Orgánico, Químico y un tratamiento testigo al que no se le realizo aplicación alguna de fertilizante; las variables consideradas dentro del proceso evaluativo fueron: altura de planta, diámetro de tallo, largo de hoja, inserción de mazorca, peso de mazorca, peso de tusa, peso de 100 granos, peso de granos, numero de hileras, disposición de las hileras y daños de la mazorca. Los resultados mostraron que el tratamiento Yara alcanzo una mayor productividad obteniendo así 38,31 kg en el peso de la parcela y que a su vez permitió evidenciar un mejor desarrollo morfológico en toda su etapa; estableciendo una altura de planta de 213,78 cm; un diámetro de planta de 72 mm y una longitud de hoja de 101,58 cm; lo cual permite contar con una mayor capacidad fotosintética gracias a su mayor cobertura foliar.
Perfil químico y actividad antioxidante de aceites esenciales de hierbas aromáticas altoandinas del Perú
Authors: Huaraca Aparco Rosa , Delgado Laime María Del Carmen , Tapia Tadeo Fidelia , Nolasco Carbajal Guido 
Published: September 2021

Las hierbas aromáticas tienen una amplia distribución en la región de Apurímac, Perú, donde encontramos especies silvestres y cultivadas, su interés se basa en la presencia de aceites esenciales que contiene componentes bioactivos que son usados como conservantes en la industria de alimentos. El objetivo de la investigación fue determinar el perfil químico y actividad antioxidante de los aceites esenciales de Lepechinia meyenii (Walp) Epling y Mentha piperita L. La extracción de aceites esenciales se realizó mediante la destilación por arrastre de vapor de agua a condiciones de sobresaturación. Se determinaron los siguientes parámetros: rendimiento de extracción, densidad relativa e índice de refracción. El perfil químico se realizó mediante la cromatografía de gases acoplada a espectrómetria de masas y la actividad antioxidante mediante la eliminación del radical libre 1,1-difenil-2-picrilhidrazilo y H2O2. (DPPH), como resultado, el porcentaje de rendimiento fue del 0,87 % y 0,56 %, con densidades de 0,942 g/mL y 0,919 g/mL y índice de refracción de 1,4917 y 1,4676 para Lepechinia meyenii (Walp) Epling y Mentha piperita L.), respectivamente. Los aceites esenciales se caracterizaron principalmente por una fracción sesquiterpenoides en un (55,73 %) y con una fracción monoterpenoides en un (55,60 %). La actividad antioxidante fue significante de 4,95-0,06 mg/mL y 7,21-0,21 mg/ mL. Los aceites esenciales a partir de hierbas aromáticas presentaron significativamente altos componentes químicos y actividad antioxidante, siendo posibles candidatos antimicrobianos, antioxidantes, antibacterianas para la industria alimentaria.
THE ROLE OF VIRTUAL AND AUGMENTED REALITY IN THE EDUCATIONAL PROCESS
Authors: Алисултанова Э.Д. , Усамов И.Р. , Мамуев А.М. 
Published: September 2021

Данное исследование посвящено рассмотрению роли виртуальной и дополненной реальности в учебном процессе. Рассмотрена характеристика виртуальной и дополненной реальности, краткая историческая справка, области применения, и проведен анализ влияния на учебный процесс обучения, выделены основные достоинства и недостатки. Сегодня технологии виртуальной и дополненной реальности развиваются и внедряются в образовательный процесс на государственном уровне. Многие учителя выявили достоинства данной технологии в процессе обучения.
This study focuses on the role of virtual and augmented reality in the educational process. The characteristics of virtual and augmented reality, a brief historical background, areas of application, and most importantly, the analysis of the impact on the educational process of learning is carried out, the main advantages and disadvantages are highlighted. Today, virtual and augmented reality technologies are being developed and implemented in the educational process at the state federal level. Many teachers have identified the advantages of this technology in the learning process.
ORGANO-INORGANIC BINDERS FOR REPAIR AND RESTORATION OF TOWER TYPE HISTORY AND CULTURE MONUMENTS
Authors: Шеина С.Г. , Батаев Д. К-С. , Муртазаев С-А. Ю. , Батаева П.Д. 
Published: September 2021

В статье делается обзор разработанных органо-неорганических составов растворов каменной кладки стен старинных башенных и некропольных строений Чеченской Республики и Республики Ингушетия. Отмечена перспективность практического применения органо-неорганических вяжущих для ремонта и реставрации памятников истории и культуры, благодаря близкому сходству разработанных составов «материнскому», за счет чего они более эффективны и способствуют повышению качества и долговечности. Исходя из анализа физико-механических свойств раствора для каменной кладки стен объектов культурного наследия рекомендованы три состава.
The article provides an overview of the developed organic-inorganic compositions of masonry solutions for the walls of ancient tower and necropolis structures of the Chechen Republic and the Republic of Ingushetia. The prospects of the practical application of organic-inorganic binders for the repair and restoration of historical and cultural monuments are noted, due to the close similarity of the developed compositions to the "mother", due to which they are more effective and contribute to improving the quality and durability. Based on the analysis of the physical and mechanical properties of the mortar for the masonry of the walls of cultural heritage objects, three compositions are recommended.
THE ROLE OF AUTOMATION OF CONTROL AND SAFETY IN THE OPERATION OF A RESIDENTIAL BUILDING
Authors: Усамов И.Р. , Кагиров М-А.С-А. , Чалаев Р.М. 
Published: September 2021

В данном исследовании рассматривается вопрос актуальности применения систем автоматизации домов в российских реалиях. Проводится обзор всевозможных вариантов автоматизации и основные проблемы с которыми сталкиваются инженера и проектировщики при внедрении механизмов автоматизации. Несмотря на наличие огромного количества различного рода проблем и не решенных вопросов, системы автоматизации домов позволяют экономить до 30% на эксплуатации. В нашей стране за последние 20 лет пересмотрели отношение к автоматизации домов, и начали внедрять технологии автоматизации в нашей стране.
This study examines the relevance of the use of home automation systems in the Russian reality. An overview of all possible automation options and the main problems faced by engineers and designers when implementing automation mechanisms is provided. Despite the presence of a huge number of various problems and unresolved issues, home automation systems allow you to save up to 30% on operation. In our country, over the past 20 years, we have revised the attitude to home automation, and began to introduce automation technologies in our country.
OPERATION AND RECONSTRUCTION OF BUILDINGS AND STRUCTURES
Authors: Баснукаев И.Ш. , Ахматова М.И. , Паршоев К.Ш. , Абуев М.А. , Джамалдаев И.М. 
Published: September 2021

Одной из ключевых сфер производственной деятельности в современных условиях является строительство. Готовой продукцией строительного производства являются здания и сооружения, которые подлежат дальнейшей эксплуатации в соответствии со своим назначением. В процессе эксплуатации зданий и сооружений осуществляется ряд работ по обеспечению их нормального функционирования, а также безаварийной работы существующих инженерно-технических систем. По мере физического и морального износа строений требуется их текущий и капитальный ремонт, а в отдельных случаях - усиление значимых конструкций. Также может осуществляться реконструкция зданий и сооружений вследствие изменения их функционального назначения. В рамках данной статьи производится исследование проблем эксплуатации и реконструкции зданий и сооружений в современных технологических условиях.
One of the key areas of production activity in modern conditions is construction. The finished products of construction production are buildings and structures that are subject to further operation in accordance with their intended purpose. During the operation of buildings and structures, a number of works are carried out to ensure their normal functioning, as well as the trouble-free operation of existing engineering and technical systems. As the physical and moral deterioration of the buildings requires their current and major repairs, and in some cases - the strengthening of significant structures. The reconstruction of buildings and structures can also be carried out due to changes in their functional purpose. This article examines the problems of operation and reconstruction of buildings and structures in modern technological conditions.