bluuebunny/crossref_metadata_2025_split huggingface dataset:
Home-Based Management of Patients With Cancer Experiencing Treatment-Induced Toxicities With a Nurse-Led Telephone Triage (the NTT Study)
Authors: Calvetti Lorenzo , Tealdo Marta , Simionato Francesca , Pagiusco Gaetana , Cimenton Roberta , Gasparin Barbara , Corà Francesco , De Vivo Rocco , Merlini Laura , Aprile Giuseppe 
Published: July 2021

PURPOSE: Novel organization models ensure early management of treatment-related adverse events (TRAEs) of new anticancer drugs. The aim of this prospective observational study was to evaluate the impact of the introduction of a nurse-led telephone triage (NTT) in reducing hospitalization of patients with cancer (CPs). PATIENTS AND METHODS: CPs on active medical treatment were educated to call the NTT in case of symptoms or TRAEs. Assessment of TRAEs was performed by trained oncology nurses according to the Common Terminology Criteria for Adverse Events grading scales and subsequent actions were taken according to the severity of the events. The primary end point of the study was to compare the rate of hospitalization of CPs on anticancer treatment after the introduction of NTT with that of the 2017-2018 period. RESULTS: From September 2018 to September 2019, a total of 1,075 patients received systemic anticancer treatment ( v 936 patients in the same 2017-2018 period). Total consultations at NTT were 429 and 581 TRAEs were reported. Notably, 117 patients reported more than one TRAE. Common Terminology Criteria for Adverse Events were graded as G1 (237, 40.8%), G2 (231, 39.8%), or G3-4 (113, 19.4%). In the observation period, 109 CPs on treatment were hospitalized versus 138 in the 2017-2018 period with a normalized hospitalization rate of 10.1% versus 14.7% ( P = .002 chi-square) with a reduction in normalized number of hospitalization of 44 and an estimated cost savings of 345,246 euros. CONCLUSION: The implementation of the NTT system in the clinical practice may help reducing the rates of hospitalization through the emergency room of CPs receiving modern medical treatments.
Zur Renovation der Dorfkirche St. Martin in Riehen
Authors: Helmig Guido , Schön Udo 
Published: July 2021

In den wenigen Schnitten, die bereits bei der Renovation im Jahr 1942 ausgehoben worden sind , wurden Fundament-Mauerzüge angeschnitten, anhand derer sich ein hochmittelalterlicher Vorgängerbau mit interessantem kreuzförmigem Grundriss rekonstruieren liess.
Die Sanierungsarbeiten in den Jahren 1993-94 erbrachten neue Erkenntnisse für Denkmalpflege und Archäologie. So waren unter dem Dach des Kreuzgewölbes noch Partien der ältesten romanischen Langschiffmauer im originalen Zustand erhalten. Zudem werden die Bauphasen der Annexbauten und deren archäologische Interpretation zusammenfassend dargestellt.
Frühe Befunde vom äusseren Ende der Spalenvorstadt
Authors: Matt Christoph Ph. , Bing Christian 
Published: July 2021

Die archäologische Untersuchung der Liegenschaft an der Spalenvorstadt 34 hat gezeigt, dass die Nutzung dieses Areals durch Gewerbebetriebe deutlich vor der ersten schriftlichen Erwähnung des Hauses einsetzte und in die Frühzeit der Vorstadt zurückreicht.
Die Anzeichen beginnen sich somit zu mehren, dass das gesamte Vorstadtgebiet zu Spalen bis zu den Toren der früheren Vorstadtbefestigungen schon recht früh überbaut worden ist.
Stiftsgasse 5
Authors: Tramèr Stephan 
Published: July 2021

Die Ergebnisse der von der Basler Denkmalpflege 1994 durchgeführten Bauuntersuchung im Gebäude Stiftsgasse 5 fügen sich nahtlos an die Resultate der Untersuchungen im benachbarten Gebäudekomplex ,,Engelhof", Stiftsgasse 1, an.
Im Haus Nr 5 wurden Reste eines mittelalterlichen Steinhauses gefunden.
Bettingen, Auf dem Buechholz, 1995/11
Authors: Ebersbach Renate , Leuch-Bartels Katrin 
Published: July 2021

Im Sommer 1995 wurde ein Hügel im Rahmen einer Lehrgrabung des Seminars für Ur- und Frühgeschichte gemeinsam mit der Archäologischen Bodenforschung untersucht, um seine mögliche prähistorische Zeitstellung zu prüfen.
Bei dem Hügel von Bettingen-Buechholz handelt es sich um eine natürliche Geländeerhebung aus plattig aufwitterndem Dolomit-Kalkstein. Anzeichen für anthropogene Eingriffe in den Hügel oder für dessen Aufschüttung in prähistorischer Zeit fehlen völlig.
A expansão dos condomínios fechados: o caso de Campos dos Goytacazes, RJ
Authors: Manhães Viviane Rangel Ribeiro , Arruda Ana Paula Serpa Nogueira de 
Published: July 2021

O presente artigo analisa a expansão dos condomínios residenciais de alto padrão na cidade de Campos dos Goytacazes, o seu impacto sobre a produção do espaço urbano, a ampliação e ressignificação das áreas periféricas e principalmente as motivações para a moradia nestes espaços. Especialmente no caso dos condomínios horizontais fechados de médio e alto padrão temos a conformação de um processo de “autossegregação”, na qual a qualidade de vida e o exclusivismo de classe parecem ser fatores determinantes no momento da escolha de se morar em um condomínio horizontal fechado, aliados ainda à presença de áreas verdes, de lazer e o status social. Cercados por muros, modernos dispositivos de segurança e de distinção de classes, vetores esses utilizados como estratégias de propaganda e venda por grandes e influentes incorporadoras, estes condomínios determinam um novo estilo de vida e normas de convívio entre os iguais, no espaço privado.
Inovação e Desenvolvimento Regional: uma análise sobre a produção científica da Universidade Estadual do Norte Fluminense e sua potencial contribuição para a sociedade
Authors: Chaffin Cezario Raquel , Terra Azevedo Filho Edson , Rego Monteiro da Hora Henrique 
Published: July 2021

O presente trabalho apresenta um estudo sobre a Universidade Estadual do Norte Fluminense Darcy Ribeiro – UENF, para averiguar qual é o papel da universidade na sociedade e, mais especificamente, analisar como esta instituição pode contribuir, por meio da produção de conhecimento, com o desenvolvimento regional via inovação. O objetivo é verificar se a produção de conhecimento e inovação contribui em alguma medida para o desenvolvimento regional, utilizando uma metodologia com abordagem quali-quantitativa mediante pesquisa bibliométrica no Banco de Dados Scopus. Constatou-se que a UENF tem gerado conhecimento por meio de publicações de documentos, principalmente na área das Ciências Agrárias e Biológicas. Conclui-se, portanto, que esta instituição tem potencial inovador e pode sim contribuir com o desenvolvimento da Região desde que haja engajamento entre ela, governoe empresa, numa Hélice Tríplice.
Capilaridade territorial na provisão de medicamentos básicos no estado do Rio de Janeiro
Authors: Manhaes Eduardo , Hasenclever Lia 
Published: July 2021

Esse artigo analisa a Política Pública de Assistência Farmacêutica (AF) nas mesorregiões do estado do Rio de Janeiro por meio da distribuição terraitorial das Unidades Básicas de Saúde (UBS) e dos estabelecimentos do Programa Farmácia Popular do Brasil rede credenciada bem como a relação existente entre a instalação de unidades de AF com o volume populacional e a renda média per capita no ano de 2018. A metodologia emprega indicadores para mensurar a correlação linear entre as variáveis e constrói mapas contendo a localização das unidades de provisionamento de medicamentos básicos. Os resultados mostram que apesar de ter havido uma expansão da provisão de medicamentos, os estabelecimentos da rede credenciada são mais concentrados e os das UBS são mais dispersos no território, o que indica um melhordesempenho destas últimas em termos de distribuição territorial.
Produção científica, capital social e o desenvolvimento regional: um estudo sobre o Norte Fluminense
Authors: Matta Ludmila Gonçalves da , Fonseca Sebastião De Melo 
Published: July 2021

O Norte Fluminense possui o segundo maior PIB entre as regiões do estado do Rio de Janeiro. Esse feito se deve, primordialmente, à presença de um conjunto de atividades produtivas de alto valor agregado e especializado alavancado pela indústria de Exploração e Produção de Petróleo e Gás. Na esteira dessa atividade, o setor de serviço tem se desenvolvido na região com uma ampla rede de saúde, de comércio e educação, entre outras. O polo educacional que se formou na região possui reconhecimento nacional e é responsável por uma expressiva produção científica. Todavia, o que chama atenção na região é o fato de, apesar da presença de atividades econômicas e produtivas de alto valor agregado, de um conjunto evidente de atividades de serviço, de um polo educacional reconhecido, os indicadores sociais ficarem na esteira do estado e do País. Tendo como baliza essa constatação, levantamos o seguinte questionamento: a produção científica (capital científico) construída nas instituições de ensino tem sido convertida em capital social e contribuído para o desenvolvimento da Região Norte Fluminense? A partir desse questionamento, tivemos como objetivos mapear as instituições de ensino e pesquisa instaladas no Norte Fluminense; levantar a produção científica por meio de teses e dissertações com o “Norte Fluminense” no título; e analisar o potencial dessa produção em se converter em capital social com capacidade de gerar desenvolvimento regional. A pesquisa tem caráter exploratório e utiliza o método qualitativo, fazendo uso de dados socioeconômicos e do levantamento das dissertações e teses. Como resultado, encontramos uma vasta produção científica com capacidade de contribuir para o desenvolvimento regional, contudo, essa conversão depende da relação entre os demais atores da sociedade, da cooperação mútua, da apropriação do conhecimento gerado pelas instituições de ensino pela sociedade, o que não tem se mostrado efetivo.
Time-domain uplink synchronization method for a spectral efficient OFDMA-based PON
Authors: Nunes Reginaldo B. , Coelho Diogo V. N. , Oliveira Gianni L. S. , Rocha Helder R. O. , Silva Jair A. L. , Segatto Marcelo E. V. 
Published: July 2021

The feasibility of a time-domain technique, proposed for uplink synchronization of the bandwidth scalable orthogonal frequency division multiple access passive optical network (BS-OFDMA PON), is experimentally demonstrated. The results show that a delay variation of less than 50% of the cyclic prefix is tolerable, relaxing the thin time synchronization required in the uplink of the evaluated architecture. Moreover, we enhance the spectral efficiency of the BS-OFDMA PON by reducing the guard band (

B
g

) between the optical carrier and the signal bandwidth, as well as by eliminating the frequency gap (

Δ

f
G

) between the optical network units. The downlink results demonstrate that

Δ

f
G

can be eliminated with negligible performance penalties, and

B
g

can be reduced to almost half the signal bandwidth. Error-free transmissions were achieved after uplink propagation over 45 km of single-mode fibers with received power of

≈

−

16.8

d
B
m

and

B
g

=
450

M
H
z

, with a signal bandwidth of 1 GHz.
Optical feedback interferometry with 40  km transmission distance based on a distributed feedback fiber laser
Authors: Tu Yourui , Zhao Yuanyang , Zhu Desheng , Li Ruifeng , Liu Keyan , Xu Lin , Zhang Lei , Cao Zhigang , Yu Benli , Lu Liang 
Published: July 2021

This Letter proposes an all-fiber self-mixing interferometric method based on laser feedback technology with long transmission distance, which has advantages of high sensitivity and compact structure. We theoretically and experimentally verify that the measurement distance of the self-mixing sensor is not limited to the coherence length of the solitary laser used. In the experiment, the velocity of a non-cooperative target was successfully measured with 40 km transmission distance. Therefore, the all-fiber self-mixing Doppler velocimeter has a great application prospect in the field of remote sensing measurement. Its unique flexibility can be applied to a variety of complex environments of non-cooperative target measurement.
Operative treatment of fragility fractures of the pelvis is connected with lower mortality. A single institution experience
Authors: Rommens Pol Maria , Boudissa Mehdi , Krämer Sven , Kisilak Miha , Hofmann Alexander , Wagner Daniel 
Published: July 2021

Background
Fragility fractures of the pelvis (FFP) represent an increasing clinical entity. Until today, there are no guidelines for treatment of FFP. In our center, recommendation for operative treatment was given to all patients, who suffered an FFP type III and IV and to patients with an FFP type IIwith unsuccessful non-operative treatment. We performed a retrospective observational study and investigated differences between fracture classes and management alternatives. We hypothetized that operative treatment may reduce mortality.

Materials and methods
The medical charts and radiographs of 362 patients were analysed. Patient demographics, FFP-classification, length of hospital stay (LoS), type of treatment, general and surgery-related complications, mortality, Short Form-8 physical component score (SF-8 PCS) and mental component score (SF-8 MCS), Parker Mobility Score (PMS) and Numeric Rating Scale (NRS) were documented.

Results
238 patients had FFP type II and 124 FFP type III and IV. 52 patients with FFP type II (21.8%) and 86 patients with FFP type III and IV (69.4%) were treated operatively (p<0.001). Overall mortality did not differ between the fracture classes (p = 0.127) but was significantly lower in the operative group (p<0.001). Median LoS was significantly higher in FFP type III and IV (p<0.001) and in operated patients (p<0.001). There were more in-hospital complications in patients with FFP type III and IV (p = 0.001) and in the operative group (p = 0.006). More patients of the non-operative group were mobile (p<0.001) and independent (p<0.001) at discharge. Half of the patients could not return in their living environment.203 of the 235 surviving patients (86%) answered the questionnaires after a mean follow-up time of 38 months. SF-8 PCS, SF-8 MCS and PMS did not differ between the fracture classes and treatment groups. Pain perception was higher in the operated group (p = 0.013).

Conclusion
In our study, we observed that operative treatment of FFP provides low mortality rates, although LoS and in-hospital complications were higher in the operative group. At discharge, the non-operative group was more mobile and independent. At follow up, quality of life and mobility were comparable between the groups. Further prospective studies are needed to clarify the impact of operative treatment of FFP on mortality and functional outcome.
Association between smoking history and optical coherence tomography angiography findings in diabetic patients without diabetic retinopathy
Authors: Liu Dong-Wei , Haq Zeeshan , Yang Daphne , Stewart Jay M. 
Published: July 2021

Purpose
To investigate any associations between cigarette smoking and retinal microvascular changes in diabetic patients without visible retinopathy.

Design
Retrospective, cross-sectional study.

Participants
1099 eyes from 1099 diabetic patients with no clinical evidence of diabetic retinopathy (DR) were included in this study.

Methods
Diabetic patients underwent optical coherence tomography angiography (OCTA) scanning at Zuckerberg San Francisco General Hospital and Trauma Center between April 2018 and September 2019. Patient demographic and clinical information was collected. Standard bivariate statistics and multivariate linear regression were performed.

Main outcome measures
OCTA parameters included metrics related to the foveal avascular zone (FAZ; area, perimeter, circularity), perfusion density (PD; full, center, inner), and vessel length density (VLD; full, center, inner).

Results
The study population included 750 non-smokers and 349 smokers. FAZ perimeter was the only OCTA parameter that was significantly different between the two groups on uncontrolled analysis (P = 0.033). Multivariate regression analyses revealed significant associations between lower VLD full (β = -0.31, P = 0.048), lower VLD inner (β = -0.35, P = 0.046) and a history of smoking. No significant associations between cigarette smoking and either FAZ or PD were detected.

Conclusions
Our results suggest that smoking is likely associated with deleterious changes in the retinal microvasculature of patients with a history of diabetes and no visible DR. Based on these findings, diabetic patients with a history of smoking may benefit from higher prioritization in terms of ophthalmic screening.
Gender-affirming care, mental health, and economic stability in the time of COVID-19: A multi-national, cross-sectional study of transgender and nonbinary people
Authors: Jarrett Brooke A. , Peitzmeier Sarah M. , Restar Arjee , Adamson Tyler , Howell Sean , Baral Stefan , Beckham S. Wilson 
Published: July 2021

Background
Transgender and nonbinary people are disproportionately affected by structural barriers to quality healthcare, mental health challenges, and economic hardship. This study examined the impact of the novel coronavirus disease (COVID-19) crisis and subsequent control measures on gender-affirming care, mental health, and economic stability among transgender and nonbinary people in multiple countries.

Methods
We collected multi-national, cross-sectional data from 964 transgender and nonbinary adult users of the Hornet and Her apps from April to August 2020 to characterize changes in gender-affirming care, mental health, and economic stability as a result of COVID-19. We conducted Poisson regression models to assess if access to gender-affirming care and ability to live according to one’s gender were related to depressive symptoms, anxiety, and changes in suicidal ideation.

Results
Individuals resided in 76 countries, including Turkey (27.4%, n = 264) and Thailand (20.6%, n = 205). A majority were nonbinary (66.8%, n = 644) or transfeminine (29.4%, n = 283). Due to COVID-19, 55.0% (n = 320/582) reported reduced access to gender-affirming resources, and 38.0% (n = 327/860) reported reduced time lived according to their gender. About half screened positive for depression (50.4%,442/877) and anxiety (45.8%, n = 392/856). One in six (17.0%, n = 112/659) expected losses of health insurance, and 77.0% (n = 724/940) expected income reductions. The prevalence of depressive symptoms, anxiety, and increased suicidal ideation were 1.63 (95% CI: 1.36–1.97), 1.61 (95% CI: 1.31–1.97), and 1.74 (95% CI: 1.07–2.82) times higher for individuals whose access to gender-affirming resources was reduced versus not.

Discussion
The COVID-19 crisis is associated with reduced access to gender-affirming resources and the ability of transgender and nonbinary people to live according to their gender worldwide. These reductions may drive the increased depressive symptoms, anxiety, and suicidal ideation reported in this sample. To improve health of transgender and nonbinary communities, increased access to gender-affirming resources should be prioritized through policies (e.g., digital prescriptions), flexible interventions (e.g., telehealth), and support for existing transgender health initiatives.
Serum adipokine profiles in patients with microscopic polyangiitis and granulomatosis with polyangiitis: An exploratory analysis
Authors: Ahn Sung Soo , Yoon Taejun , Song Jason Jungsik , Park Yong-Beom , Lee Sang-Won 
Published: July 2021

Objectives
Previous studies have shown that adipokines may serve as potential biomarkers reflecting disease activity in various autoimmune diseases. Here, we investigated the relationship between four adipokines and clinical/laboratory findings in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA).

Methods
Sera from 63 patients with MPA and GPA who were registered in a prospective cohort were used to detect serum levels of adiponectin, chemerin, resistin, and vaspin using commercial enzyme-linked immunosorbent assay kits. Associations between adipokines and clinical and laboratory data was assessed using Pearson’s correlation analysis.

Results
The median age was 65.0 years, 24 patients were male, and 42 patients were diagnosed with MPA. The median levels of adiponectin, chemerin, resistin, and vaspin in patient sera were 13.9 ng/mL, 9.2 ng/mL, 23.7 ng/mL, and 0.1 ng/mL, respectively. A significant correlation between chemerin level and five-factor score (FFS) was found (r = 0.320, p = 0.011), and resistin was correlated with both Birmingham vasculitis activity score and FFS (r = 0.256, p = 0.043 and r = 0.320, p = 0.011). Regarding laboratory data, adiponectin level was associated with creatinine, and chemerin level was associated with creatinine, albumin, and erythrocyte sedimentation rate (ESR). On the other hand, resistin was found to be associated with white blood cell count, creatinine, ESR, and C-reactive protein. Age did not have a significant impact on the levels of adipokines.

Conclusions
The expression of adipokines in the sera of patients with MPA and GPA differs depending on clinical and laboratory features, and serum resistin may be suggested as a potential biomarker reflecting disease activity.
A patient-oriented research approach to assessing patients’ and primary care physicians’ opinions on trauma-informed care
Authors: Kokokyi Seint , Klest Bridget , Anstey Hannah 
Published: July 2021

ObjectiveTo gather patients’ and primary care physicians’ (PCP) opinions on trauma-informed Care (TIC) and to investigate the acceptability of recommendations developed by patient, family, and physician advisors.DesignCross-sectional research survey design and patient engagement.SettingCanada, 2017 to 2019.ParticipantsEnglish-speaking adults and licensed PCPs residing in Canada.Main outcome measuresParticipants were given a series of questionnaires including a list of physician actions and a list of recommendations consistent with TIC.ResultsPatients and PCPs viewed TIC as important. Both patients and PCPs rated the following recommendations as helpful and likely to positively impact patient care: physician training, online trauma resource centres, information pamphlets, the ability to extend appointment times, and clinical pathways for responding to trauma. PCPs’ responses were significantly more positive than patients’ responses.ConclusionTIC is important to patients and PCPs. Patients and PCPs believe changes to physician training, patient engagement, and systemic factors would be helpful and likely to positively impact patient care. Future research needs to be conducted to investigate whether these recommendations improve patient care.