bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome of COVID-19 in Solid Organ Malignancies: Experience From a Tertiary Cancer Center in Eastern India
Authors: Roy Somnath , Ghosh Joydeep , Ganguly Sandip , Mondal Debapriya , Dabkara Deepak , Chatterji Soumyadip , Biswas Bivas 
Published: September 2021

PURPOSE The COVID-19 pandemic has imposed a unique challenge to oncology patients. Outcome data on COVID-19 in patients with cancer from the Indian subcontinent are scarce in the literature. We aimed to evaluate the outcome of patients with COVID-19 on active systemic anticancer therapy. MATERIALS AND METHODS This is a retrospective study of patients with solid organ malignancies undergoing systemic therapy with a diagnosis of COVID-19 between March 2020 and February 2021. COVID-19 was diagnosed if a reverse transcriptase polymerase chain reaction assay from oropharyngeal or nasopharyngeal swab was positive for severe acute respiratory syndrome coronavirus 2. The objectives were to evaluate the outcome of COVID-19 and factors predicting the outcome. RESULTS A total of 145 patients were included with a median age of 58 years (range, 20-81 years). Treatment was curative in 60 (42%) patients. Of all symptomatic cases (n = 88, 61%), 50 had mild, 27 had moderate and 19 had severe COVID-19–related symptoms as per WHO criteria. Fifty (34%) patients required hospitalization with a median duration of hospital stay of 12 days (range, 4-25 days); five patients required intensive care unit admission. The rest were treated with home isolation and did not require further hospitalization. Twenty-two (15%) patients died, and the risk of death was significantly associated with severity of symptoms (odds ratio, 91.3; 95% CI, 9.1 to 919.5, P = .0001) but not with any other clinical factors. Drug holiday was given to 63 (44%) patients with a median duration of 25 days (range, 7-88 days). The median duration to reverse transcriptase polymerase chain reaction–negative was 16 days (range, 7-62 days). CONCLUSION COVD-19–related death rate was 15% among patients with solid organ malignancies. The severity of the symptoms was related to mortality. The majority of patients with mild symptoms were treated at home isolation.
Steady state of the KPZ equation on an interval and Liouville quantum mechanics
Authors: Barraquand Guillaume , Le Doussal Pierre 
Published: September 2021

Abstract
We obtain a simple formula for the stationary measure of the height field evolving according to the Kardar-Parisi-Zhang equation on the interval

with general Neumann-type boundary conditions and any interval size. This is achieved using the recent results of Corwin and Knizel (arXiv:2103.12253) together with Liouville quantum mechanics. Our formula allows to easily determine the stationary measure in various limits: KPZ fixed point on an interval, half-line KPZ equation, KPZ fixed point on a half-line, as well as the Edwards-Wilkinson equation on an interval.
Myopia and Early-Onset Type 2 Diabetes: A Nationwide Cohort Study
Authors: Peled Alon , Raz Itamar , Zucker Inbar , Derazne Estela , Megreli Jacob , Pinhas-Hamiel Orit , Einan-Lifshitz Adi , Morad Yair , Pras Eran , Lutski Miri , Cukierman-Yaffe Tali , Mosenzon Ofri , Tzur Dorit , Tirosh Amir , Gerstein Hertzel C , Afek Arnon , Twig Gilad 
Published: September 2021

Abstract

Context
A correlation between myopia and insulin resistance has been suggested.

Objective
We investigated the association between myopia in adolescence and type 2 diabetes (T2D) incidence in young adulthood.

Methods
This population-based, retrospective, cohort study comprised 1 329 705 adolescents (579 543 women, 43.6%) aged 16 to 19 years, who were medically examined before mandatory military service during 1993 to 2012, and whose data were linked to the Israel National Diabetes Registry. Myopia was defined based on right-eye refractive data. Cox proportional models were applied, separately for women and men, to estimate hazard ratios (HRs) for T2D incidence per person-years of follow-up.

Results
There was an interaction between myopia and sex with T2D (P &lt; .001). For women, T2D incidence rates (per 100 000 person-years) were 16.6, 19.2, and 25.1 for those without myopia, and with mild-to-moderate and high myopia, respectively. These corresponded to HRs of 1.29 (95% CI, 1.14-1.45) and 1.63 (1.21-2.18) for women with mild-to-moderate and high myopia, respectively, compared to those without myopia, after adjustment for age at study entry, birth year, adolescent body mass index, cognitive performance, socioeconomic status, and immigration status. Results persisted in extensive sensitivity and subgroup analyses. When managed as a continuous variable, every 1-diopter lower spherical equivalent yielded a 6.5% higher adjusted HR for T2D incidence (P = .003). There was no significant association among men.

Conclusion
For women, myopia in adolescence was associated with a significantly increased risk for incident T2D in young adulthood, in a severity-dependent manner. This finding may support the role of insulin resistance in myopia pathogenesis.
Single-Component Molecular Conductors — Multi-Orbital Correlated π-d Electron Systems
Authors: Kobayashi Akiko , Zhou Biao , Takagi Rina , Miyagawa Kazuya , Ishibashi Shoji , Kobayashi Akito , Kawamura Taiki , Nishibori Eiji , Kanoda Kazushi 
Published: September 2021

Abstract
Traditional molecular conductors are composed of more than two chemical species. Two prerequisites for the design of molecular metals have long been considered to be 1) forming of the electronic band and 2) existence of charge carriers created by the intermolecular charge transfer between the molecules constructing the band and other chemical species. On the other hand, a single-component molecular metal, [Ni(tmdt)2] (tmdt = trimethylenetetrathiafulvalenedithiolate), was developed in 2001; it is a planar nickel complex coordinated by the extended-TTF dithiolate ligands, tmdt from both sides. Since then, various types of single-component molecular conductors with a variety of extended-TTF dithiolate ligands have been developed. In this account, we briefly describe the recent progress in research on single-component molecular conductors. First, single-component molecular conductors in isostructural systems, [M(tmdt)2] (M = Ni, Pd, Pt, Au, and Cu) are described. Recent orbital-selective 13C and 1H NMR experiments have genealogically elucidated the differences in the electronic states and physical properties of these systems, that is, their various unusual phenomena are produced from their multi-orbital correlated π or π-d electron systems. Next, we describe [Ni(hfdt)2] (hfdt = bis(trifluoromethyl)tetrathiafulvalenedithiolate), the first single-component molecular superconductor, which was revealed by high-pressure resistivity measurements with a diamond anvil cell (DAC). The superconducting transition occurred around 7.5–8.7 GPa with a maximum Tc (onset temperature) of 5.5 K. Recent theoretical calculation has revealed that [Ni(hfdt)2] will be a new molecular Dirac electron system. In the final section, we briefly introduce molecular Dirac electron systems. Recently, a new series of semimetals, [M(dmdt)2] (M = Pt and Ni; dmdt = dimethyltetrathiafulvalenedithiolate) was synthesized. They belong to a three-dimensional ambient-pressure molecular massless Dirac electron system. The first-principles band structure calculations of [M(dmdt)2] (M = Pt and Ni) revealed that Dirac cones emerge along the a* direction and form Dirac nodal lines.
Application of X-ray image measurement in the early diagnosis of sports injury of ankle ligament
Authors: Meng Shuqiao , Tong Wenxia , Han Shanshan 
Published: September 2021

Objectives: To study the value of X-ray analysis method of ankle fracture based on injury mechanism to improve the imaging diagnosis level of ankle fracture.
Methods: This study was conducted from January 2016 to December 2019. It included 105 cases of fractures caused by sprained ankle joints. Their age was between 21-81 years with an average of 49.5 years, The traditional X-ray analysis method (Group-A) and the injury mechanism-based ankle fracture X-ray analysis method (Group-B) were used to analyze X-ray image data. Group-B also performed Weber classification and Lauge-Hansen classification on cases. Installment.
Results: Of the 105 patients with ankle fractures, 97 patients in Group-B were able to make Lauge-Hansen classification. Of these 97 ankle fractures, 137 were found in Group-A, and 158 were found in Group-B. The wrong diagnosis of fracture in Group-A was 18%, and the wrong diagnosis of fracture in Group-B was 0.5%. There was a statistically significant difference between the two groups (P <0.05).
Conclusion: The X-ray analysis method of ankle fractures based on injury mechanism can effectively improve the detection rate of hidden ankle fractures and high fibular fractures, and reduce the missed diagnosis, which is superior to the traditional X-ray analysis methods. At the same time, Weber classification, Lauge-Hansen classification and staging can be made for most cases, which is conducive to guiding clinical treatment.
doi: https://doi.org/10.12669/pjms.37.6-WIT.4841
How to cite this:Meng S, Tong W, Han S. Application of X-ray image measurement in the early diagnosis of sports injury of ankle ligament. Pak J Med Sci. 2021;37(6):1580-1584. doi: https://doi.org/10.12669/pjms.37.6-WIT.4841
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Ultrasound Doppler fetal heart rate detection algorithm analyzesthe correlation between twin selective fetal growth restriction and cord blood SFass fasL level
Authors: Cao Qiaohong , Ma Cong , Zhu Junbiao 
Published: September 2021

Objective: The paper uses ultrasound Doppler fetal heart rate detection algorithm to explore the placental characteristics of monochorionic twin pregnancy with selective fetal growth restriction, and discuss the correlation between selective fetal growth restriction and cord blood SFass FasL level.
Methods: From June 1, 2019 to June 1, 2020 in our hospital, 23 cases of selective fetal growth restriction and 32 cases of uncomplicated cases were included in the monochorionic twin pregnancies whose pregnancy was terminated in our hospital (control group) research. Perfusion was completed within 24 hours after delivery of the placenta. The umbilical arteries and veins of the two fetuses were respectively perfused with four different colors of pigments. The type of anastomoses was judged according to the color of the blood vessels on the placenta surface.
Results: The selective fetal growth restriction group was higher than the control group. In the selective fetal growth restriction group and the control group, the number of anastomoses of the placental superficial arterial artery, arterial vein and venous vein were 1.0 and 1.0, 3.0 and 2.0, 0.0 and 0.0, respectively; the placental superficial arterial artery, arterial vein and venous vein. The total diameters of the anastomosed blood vessels were 2.7 and 2.2, 4.0 and 3.4, 0.0 and 0.0 mm, respectively; the total number of superficial placental anastomosed blood vessels in the selective fetal growth restriction group and the control group were 3.5 and 3.5, respectively.The total diameters were 6.9 and 6.9, respectively 5.9mm.
Conclusion: Uneven placental share and non-central attachment of the umbilical cord may be risk factors for selective fetal growth restriction in monochorionic twin pregnancy.
doi: https://doi.org/10.12669/pjms.37.6-WIT.4881
How to cite this:Cao Q, Ma C, Zhu J. Ultrasound Doppler fetal heart rate detection algorithm analyzes the correlation between twin selective fetal growth restriction and cord blood SFass fasL level. Pak J Med Sci. 2021;37(6):1672-1676. doi: https://doi.org/10.12669/pjms.37.6-WIT.4881
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Adoption of computerized tomography perfusion imaging in the diagnosis of acute cerebral infarct under optimized deconvolution algorithm
Authors: Fang Bo , Zhai Hongjiang 
Published: September 2021

Objectives: To explore the significance of the hemodynamic parameters of Computerized Tomography Perfusion Imaging (CTPI) under the deconvolution optimization algorithm for the diagnosis and treatment of patients with acute cerebral infarct (ACI).
Methods: A hundred and ten patients with ACI from December 2018 to September 2019 were selected for research, and CTPI was performed before and after Edaravone injection treatment. Then, the CTPI deconvolution algorithm based on the weighted adaptive (WA) total variation (TV) (WA-TV) optimization was constructed, which was compared with tensor total variation (TTV) and Motion-adaptive sparse parity (MASP). Brain Perfusion 4.0 was applied to obtain the relative time to peak (rTTP), the relative transit time of mean (rMTT), relative cerebral blood volume (rCBV), and relative cerebral blood flow (rCBF) of the core infarction area (CIA) and penumbra ischemic (PI).
Results: In four parameters of rTTP, rMTT, rCBV, and CBF, the peak signal to noise ratio (PSNR) of the WA-TV algorithm was higher than the MSAP and TTV algorithms, while the Mean Square Error (MSE) and Mean Absolute Error (MAE) were lower than MSAP and TTV algorithms (P<0.05); the parameters of rCBV (71.56±9.87), rCBF (43.17±7.06) of the CIA before treatment were higher than PI (23.66±7.22; 18.37±3.99), rMTT (124.83±9.73) and rTTP (122.57±7.41) were lower than the PI (183.17±10.16); 150.74±9.74) (P<0.05). After treatment, the rCBV and rCBF of PI were higher than before treatment, and rMTT and rTTP were lower than before treatment (P<0.05), and there was no obvious difference in rCBV, rCBF, rMTT, and rTTP before and after treatment in the CIA (P>0.05).
Conclusion: Compared with TTV and MASP, the WA-TV algorithm performs better in noise reduction and artifact reduction. The CTPI parameters of rCBV, rCBF, rMTT, and rTTP are all important indications for the diagnosis of PI and ACI.
doi: https://doi.org/10.12669/pjms.37.6-WIT.4884
How to cite this:Fang B, Zhai H. Adoption of computerized tomography perfusion imaging in the diagnosis of acute cerebral infarct under optimized deconvolution algorithm. Pak J Med Sci. 2021;37(6):1687-1692. doi: https://doi.org/10.12669/pjms.37.6-WIT.4884
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Strengthening the referral Chain and providing one window diabetes eye care facility to people with Type-2 Diabetes: A six-year follow-up study from Pakistan
Authors: Ahsan Shahid , Memon Muhammad Saleh , Fahim Muhammad Faisal , Mahmood Tauseef , Shaikh Sikander Ali 
Published: September 2021

Objective: To report the results of implementation of two-pronged system for strengthening of referral and receiving end of referral chain for people with Type-2 diabetes mellitus (T2DM) at a tertiary eye care hospital in Karachi.
Methods: This observational, cross sectional study was conducted from the data collected in “Strengthening Pakistan’s response to Diabetic Retinopathy” project. Peripheral referral was improved through community awareness camps (n=48), refreshing knowledge of primary healthcare professionals (PHCP) and conducting retinopathy screening camps (n=85) in the community. T2DM patients with best corrected visual acuity (BCVA) <6/18 or had retinopathy sign on screening were referred to tertiary center. The receiving end of the referral was improved by establishing “one window facility” at tertiary eye care center. Facility consisted of eight stations starting from registration, visual assessment, fundus photographs, consultation with ophthalmologist, anthropometry measurement, consultation with diabetologist to finally meeting with diabetes educator. At every station, patient’s information was directly entered in HIMS software.
Results: A total of 50,595 patients attended tertiary center over six years. Among all 34685 (68.5%) were new registration and 15910 (31.4%) were follow ups. During first year (2014-15) out of total registered individuals with DM, newly registered were 4414 (89.5%) and 518 (10.5%) were follow-ups. In the final year (2019-20) new cases registered reached to 62% (n= 7916) with 38% (n=4852) follow-ups. Patients referred by PHCP increased from 6.5% in 2014-15 to 43.7% in 2019-20. An increased uptake of all treatment modalities for retinopathy like laser (increased by 16.76%), intra-vitreal injections (by 14.72%) and vitrectomy (by 51.47%) were also observed.
Conclusion: Implementation of two prong system resulted in improved service uptake, better referral system, enhanced follow-ups and increased intervention uptake.
doi: https://doi.org/10.12669/pjms.37.7.3946
How to cite this:Ahsan S, Memon MS, Fahim MF, Mahmood T, Sheikh SA. Strengthening the referral Chain and providing one window diabetes eye care facility to people with Type-2 Diabetes: A six-year follow-up study from Pakistan. Pak J Med Sci. 2021;37(7):---------. doi: https://doi.org/10.12669/pjms.37.7.3946
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Changes of Serum Ficolin-3 and C5b-9 in Patients with Heart Failure
Authors: Li Hongli , Zhang Fangfang , Zhang Dan , Tian Xiang 
Published: September 2021

Objectives: To investigate the correlation of serum ficolin-3 and C5b-9 with cardiac function and NT-proBNP in patients with heart failure.
Methods: Sixty patients with heart failure admitted to the Baoding First Central Hospital from May 2019 to May 2020 were selected and divided into three groups according to the classification of New York Heart Association (NYHA). Patients with NYHA grade II, III, and IV were included into group A, B, and C, respectively. Among the population undergoing physical examination at the same time, 20 cases with no significant difference in age and gender from the experimental group were selected as the control group (Group-N), and their clinical data were recorded. The serum levels of ficolin-3, C5b-9 and NT-proBNP in each group were detected and compared.
Results: The serum concentrations of ficolin-3 and C5b-9 in Group N were significantly different from those in Group A, B and C (p<0.05), the difference between Group C and Group A and B was statistically significant (p<0.05), there was no significant difference between group A and B (p>0.05). The correlation analysis between serum ficolin-3 and NT-proBNP showed that serum ficolin-3 was negatively correlated with NT-proBNP (r=-0.606, p<0.0001), while the correlation analysis between serum C5b-9 and NT-proBNP showed that serum C5b-9 was positively correlated with NT-proBNP (r=0.499, p<0.0001). According to the etiology of heart failure, patients with heart failure were divided into coronary heart disease (25 cases), dilated cardiomyopathy (15 cases) and others (20 cases). The differences of ficolin-3 and C5b-9 among patients were compared, and there was no statistical difference (p<0.05).
Conclusion: Ficolin-3 was inversely associated with the severity of heart failure, while C5b-9 was positively associated with the severity of cardiac impairment. Both of them have nothing to do with the etiology of heart failure.
doi: https://doi.org/10.12669/pjms.37.7.4151
How to cite this:Li H, Zhang F, Zhang D, Tian X. Changes of Serum Ficolin-3 and C5b-9 in Patients with Heart Failure. Pak J Med Sci. 2021;37(7):---------. doi: https://doi.org/10.12669/pjms.37.7.4151
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Clinical and Lab profile of severe and uncomplicated malaria: A prospective study from Khuzdar Balochistan
Authors: Khan Memoona , Nisar Haider , Mushahid Nuzhat 
Published: September 2021

Objectives: Khuzdar, the largest city of Southern Balochistan, is endemic for malaria with API of 6. The study was aimed at comparing the clinico-lab profile of severe and uncomplicated malaria in the region and to determine any association with age. No such study is reported in the region so far.
Methods: A prospective clinical observational study was conducted in Combined Military Hospital, Khuzdar between 2018 and 2020. A total of 210 Malaria patients, irrespective of age and gender were included. Cases were categorized into severe and uncomplicated according to WHO criteria. The clinical parameters and lab profile of severe and uncomplicated cases were compared and data was analyzed using SPSS 23.0. Categorical variables were analyzed for association of clinical features with severe malaria using Fisher exact test. Continuous variables were compared between uncomplicated and severe malaria using Mann-Whitney U –test. Statistical significance of lab parameters with type of malaria was derived using Kruskal Wallis.
Results: Uncomplicated and severe cases were 191 (91%) and 19 (9%) respectively. Severe malaria was significantly associated with jaundice, bleeding from gums, epistaxis, pallor, vomiting, respiratory distress, thrombocytopenia, low Hb, raised serum bilirubin and raised PT (p value<0.05). In children, frequency of multiple complications was significantly higher than adult patients. (75% vs 25%, p-value 0.002).Overall case fatality of severe malaria was 5.2% (1/19). However, case fatality rate was 100% in cerebral malaria.
Conclusions: Certain clinical and lab parameters can be used to predict prognosis and thus avoid adverse outcome in malaria patients.
doi: https://doi.org/10.12669/pjms.37.7.4210
How to cite this:Khan M, Nisar H, Mushahid N. Clinical and Lab profile of severe and uncomplicated malaria: A prospective study from Khuzdar Balochistan. Pak J Med Sci. 2021;37(7):---------. doi: https://doi.org/10.12669/pjms.37.7.4210
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.