bluuebunny/crossref_metadata_2025_split huggingface dataset:
A phase Ib/II study of the polo-like kinase 1 (PLK1) inhibitor, onvansertib, in combination with FOLFIRI and bevacizumab for second-line treatment of patients with KRAS-mutated metastatic colorectal Cancer (mCRC).
Authors: Ahn Daniel H. , Ridinger Maya , Erlander Mark , Bekaii-Saab Tanios S. , Lenz Heinz-Josef 
Published: January 2021

TPS155 Background: Chemotherapy in combination with targeted agents are standard-of-care options for patients for mCRC with response rates > 50% in first line. In the second line setting, efficacy of chemotherapy and targeted agents are much lower with response rates of 5% for FOLFIRI (5-fluorouracil, leucovorin, irinotecan) + bevacizumab (anti-VEGF). New treatment options are urgently needed in particular for the 50 % of patients harboring a KRAS mutation. PLK1 is a serine/threonine kinase, master regulator of the mitotic checkpoint and cell division. PLK1 is overexpressed in CRC and its overexpression is associated with poor prognostic. A genome wide RNAi screen identified PLK1 as a synthetic lethal target in KRAS mutant CRC cells, inducing cell cycle arrest and apoptosis upon inhibition. Onvansertib is an oral, highly selective PLK1 inhibitor that demonstrates single agent and synergistic activity with irinotecan and 5-FU in preclinical CRC models. Additionally, KRAS mutated versus wild-type cells showed higher sensitivity to onvansertib. PLK1 inhibition is a potential target in KRAS-mutated mCRC, and the combination of onvansertib + FOLFIRI + bevacizumab may provide a new second-line treatment option. Methods: The primary objective of this single-arm Phase 1b/2 study is to assess the safety and preliminary efficacy of onvansertib in combination with FOLFIRI and bevacizumab in the second line setting for KRAS-mutated mCRC patients. For the Phase 1b segment, a standard 3 + 3 dose-escalation design is used to determine the maximum tolerated dose or recommended phase 2 dose (RP2D) of onvansertib. As of September 15th 2020, the first two dose levels have been cleared for safety and the third is enrolling. Efficacy will be determined by objective response rate (ORR) according to RECIST v1.1 (primary endpoint), progression-free survival and reduction in KRAS allelic burden in liquid biopsies (secondary endpoints). Biomarker analyses include genomic profiling of circulating tumor DNA genomic to evaluate altered pathways that correlate with patient clinical response. Based on a one-sided one sample log-rank test with 10% Type I error, there will be at least 90% power to detect an improvement in ORR from 5% to 20% with 32 patients. Clinical trial information: NCT03829410.
Quando o Bom Conhecedor de Almas se Torna Psicólogo Experimentante
Authors: Sousa Elisabete Marques Jesus de 
Published: January 2021

O principal objetivo deste capítulo é analisar e comentar o que o ecléctico pensador dinamarquês Søren Kierkegaard (1813-1855) entende por conhecedor de almas (sjelekyndig), um termo que este filósofo e poeta peculiar faz equivaler a psicólogo na obra Para auto-exame, recomendado à época contemporânea. Em concordância com este objectivo, é analisado e comentado o modus operandi do psicólogo experimentante (experimenterende) tal como é assumido por vários dos seus autores narradores, designadamente, Johannes Climacus (em Pós-Escrito), Johannes de silentio (em Temor e Tremor) e Frater Taciturnus (em Estádios no Caminho da Vida). Experimenterende, ou seja, aquele que é definível pela prática da sua capacidade de experimentar, é efetivamente o adjectivo que com maior frequência surge a qualificar o termo "psicólogo". Nesta minha análise, é realçado o papel da imaginação no autor e no leitor e o modo como se associa à faculdade do juízo na interação leitor-texto-autor. É também sublinhado o papel fundamental do poético e do literário em todo este processo.
Self e Autenticidade: Dilemas Conceituais sob a Perspectiva de Merleau-Ponty
Authors: Marcon Gilberto Hoffmann , Furlan Reinaldo 
Published: January 2021

Propomos mapear as implicações do pensamento fenomenológico para as temáticas correlatas do self e da autenticidade, com ênfase na perspectiva merleau-pontyana. Perpassando as acepções distintas dos fatores identitário, unitário e relacional da experiência humana, encontramos três eixos tensionais em torno dos quais o conceito de self pode ser articulado: constância ou mudança, particularidade ou universal e pessoa ou mundo. Sob os diferentes enfoques descritivos deste campo de problemas, tais dilemas epistemológicos encontram-se redobrados em tensões éticas quando nos reportamos à questão da autenticidade. Enquanto as filosofias de Heidegger e Sartre, sob aproximações diferentes, concedem relativa centralidade à problemática da autenticidade, a fenomenologia de Merleau-Ponty, mesmo situada no diálogo direto com tais aportes de raiz comum husserliana, não concede ao tema a mesma importância de forma explícita. Ao tematizar o caráter eminentemente ambíguo da corporeidade, Merleau-Ponty oferece uma compreensão original da experiência do self e do ser autêntico: em contraponto à possibilidade radical de recuo, a inerência radical de contato. Concluímos que tal perspectiva apresenta como ganho a habilitação da apreensão descritiva, sem cair em contradição, do que há de concretude no indeterminado, de universal na singularização e de passividade na liberdade - e vice-versa, para todos os casos.
Um Caminho com Sartre: Apropriações de seus Métodos para uma Clínica Fenomenológica-Existencial
Authors: Souza Rodolfo Rodrigues de 
Published: January 2021

O pensamento do filósofo francês Jean-Paul Sartre é atravessado pela constituição de diferentes propostas metodológicas. No fim da década de 1930, fala em um método regressivo ao estudar as relações entre imaginação e consciência. Em O Ser e o Nada, de 1943, apresenta a Psicanálise Existencial, ora tomada como um método em si, ora como uma proposta que se vale de um método, chamado de comparativo. Já em 1957, com Questões do Método, apresenta o método progressivo-regressivo, em maior contato com o pensamento marxista e com a História. Este artigo busca apresentar tal caminhada metodológica, ensaiando diálogos com o campo da psicoterapia fenomenológica-existencial. Defende-se que todas essas diferentes propostas formam uma totalidade de olhares que torna mais complexa as possibilidades de compreensão do analisando no horizonte clínico. O estudo do método progressivo-regressivo, em adição à Psicanálise Existencial, cujas relações com o campo da clínica parecem mais evidentes, permite a constituição de um fazer que não recaia em uma prática interpretativa ou explicativa.
Using narrative messages to improve parents' experience of learning that a child has overweight
Authors: Gillison Fiona B. , Grey Elisabeth B. , McConnell Hannah E. , Sebire Simon J. 
Published: January 2021

Background: Providing feedback to parents that their child has overweight often elicits negative reactance. Aims: To investigate the acceptability and feasibility of providing theoretically-informed narrative messages to reduce negative reactance, alongside the National Child Measurement Programme (NCMP) feedback informing parents when their child has overweight. Methods: A mixed-methods design: interviews with parents of primary school-aged children explored responses to the narratives; a pilot randomised trial examined the feasibility, acceptability and promise of enclosing narratives with NCMP feedback. Findings: Interview participants found the narratives acceptable and indicated they could help lessen negative reactance. Pilot study data suggested 65% of parents could identify with the characters, with evidence of elaboration (applying the story to one's own situation) evident in 47% of those reading the accounts.
Gyroscopic performance and some seismic measurements made with a 10 meter perimeter ring laser gyro housed in the Ernest Rutherford building
Authors: Zou Dian , Thirkettle Robert J. , Gebauer André , MacDonald Graeme K. , Schreiber K. Ulrich , Wells Jon-Paul R. 
Published: January 2021

We describe the construction and operation of a large ring laser whose
beam paths enclose an area of

6.25

m

2

. The gyroscopic performance of this
large laser interferometer was determined using laser operation at a
wavelength of 632.8 nm. The laser cavity Q was inferred to be

1.1
×

10

12

via a measured ring-down time of
375 µs, and the measured Sagnac frequency is 198.40 Hz due to Earth’s
rotation. The measured experimental sensitivity to rotation achieved
is

7.9
×

10

−
12

r
a
d

/

s

/

H
z

at an averaging interval of 512 s
(being limited primarily by ambient building noise). The observation
of microseismic activity in the 200 mHz region as well as local
earthquakes is discussed.
Patterned liquid crystal polymer C-plate retarder and color polarizer
Authors: Miller Sawyer , Jiang Linan , Tu Xingzhou , Pau Stanley 
Published: January 2021

The patternability and guest–host interaction with dichroic dye and
C-plate liquid crystal polymer (LCP) materials are investigated, and
the optical properties of a thin film C-plate retarder and polarizer
are studied and compared with theory. The C-plate retarder is a
waveplate made of a uniaxial LCP where the optical axis of the LCP is
parallel to the surface normal of the optic. No retardance is observed
at a normal angle of incidence and retardance grows as the angle of
incidence increases. The C-plate polarizer is a C-plate retarder with
LCP as the host and a dichroic dye as the guest. The linear
diattenuation (LD) of the linear polarizer is zero at a normal angle
of incidence and grows with an increasing angle of incidence. Both the
C-plate retarder and polarizer can be patterned with minimum feature
size down to 2 µm by using ultraviolet photolithography and plasma
etching. A planarization process is also developed to deposit a cover
layer on top of the pattern to reduce optical loss and to serve as a
barrier for subsequent layers.
Simultaneous measurement of refractive index and temperature or temperature and axial strain based on an inline Mach–Zehnder interferometer with TCF–TF–TCF structure
Authors: Zhang Wujun , Wu Xuqiang , Zhang Gang , Shi Jinhui , Zuo Cheng , Fang Shasha , Gui Lei , Yu Benli 
Published: January 2021

A refractive index (RI) and temperature or a temperature and axial
strain sensor based on an inline Mach–Zehnder interferometer with thin
core fiber (TCF)–thin fiber (TF)–TCF structure is proposed and
experimentally demonstrated, requiring only the cleaving and fusion
splicing methods. The operation principle depends on the effect that
the TF cladding modes interfere with the core mode as an optical
coupler. The RI, temperature, or axial strain variations can lead to
resonance dip variations in the interferometer spectra, and the RI,
temperature, or axial strain sensitivity can be measured by monitoring
the wavelength shifts of resonance dips. Then we can measure both RI
and temperature, or temperature and axial strain through the
demodulation matrix. Four sensors with different TF lengths are
fabricated based on numerical simulation. A 15 mm long TF sensor
displays an RI sensitivity as high as

−

174.357

n
m

/

R
I
U

, temperature sensitivities in the
glycerin solution and the air of 12.47 and 26.19 pm/°C, and axial
strain sensitivity of

−

3.43

×

10

−
4

n
m

/

µ
ε

. Moreover, due to its simple
manufacture, high cost-effectiveness and compactness, the proposed
sensor has a broad application prospect in physical, chemical, and
biological sensing.
Stimulated Brillouin scattering in high-birefringence elliptical-core As2Se3-PMMA microfibers
Authors: Wang Haiyang , Baker Chams , Chen Liang , Bao Xiaoyi 
Published: January 2021

In this Letter, we design and fabricate elliptical-core (ECORE) chalcogenide-polymethyl methacrylate (

A
s

2

S
e

3

-PMMA) microfibers to explore the birefringence impact on stimulated Brillouin scattering. Numerical simulations based on the finite-element method and elastodynamic equation are utilized to calculate the phase and group birefringence and Brillouin gain spectra of the fundamental mode in three ECORE

A
s

2

S
e

3

-PMMA microfibers at different core diameters. Experimentally measured and numerically calculated results show that as the core diameter of the minor axis of an ECORE microfiber with a ratio of 1.108 is reduced from 1.50 µm to 0.87 µm, a high group birefringence of

∼

10

−
3

to

∼

10

−
2

and a large Brillouin frequency shift difference of

∼

6

M
H
z

to

∼

30

M
H
z

are achieved, while the Brillouin gain spectra are broadened significantly from

∼

70

M
H
z

to

∼

140

M
H
z

. The high-birefringence ECORE

A
s

2

S
e

3

-PMMA microfiber is important for Brillouin sensing due to the tailorable high birefringence and ultrahigh nonlinearity.
Family planning utilization and associated factors among postpartum women in Addis Ababa, Ethiopia, 2018
Authors: Tafa Lema , Worku Yoseph 
Published: January 2021

Background
Pregnancies that occur in the first year after birth can result in adverse outcomes for the mothers and their babies. Postpartum family planning (PPFP) can save lives of many mothers and children. Only few data are available about the magnitude of PPFP use and its determinants in Addis Ababa, Ethiopia.

Objective
To assess PPFP utilization and associated factors in Addis Ababa, Ethiopia.

Method
A facility-based cross-sectional study was conducted from April to June 2018. A total of 625 women were enrolled in the study. Statistical Package for the Social Sciences (SPSS) software was used to analyze the data. Binary logistic regression model with adjusted odd ratio (AOR) and 95% confidence interval (CI) was used to identify the factors associated with PPFP use. A p-value less than 0.05 was considered as significant.

Result
The magnitude of PPFP utilization in Addis Ababa was 71.8%. Previous family planning (FP) information (AOR = 13.2; 95% CI: (1.96, 88.07)), FP information from health facility visit (AOR = 2.23; 95% CI: (1.45, 3.43)), antenatal care (AOR = 4.96; 95% CI: (1.58, 15.64)), counseling on FP at postnatal care (AOR = 1.97; 95% CI: (1.27, 3.05)), menses resumption after birth (AOR = 1.75; 95% CI: (1.11, 2.76)), and commencing sexual activity after birth (AOR = 9.34; 95% CI: (5.39, 16.17)) were the factors associated with PPFP use.

Conclusion and recommendation
Though the magnitude of PPFP use is encouraging, still three out of the ten postpartum women did not use PPFP. The determinants of PPFP use were having FP information, having FP information from health facility visit, antenatal care, counseling about FP during postnatal care, menses resumption after birth, and commencing sexual activity after birth. The health system in the City and the healthcare providers should strive to reach every woman who is not accessing the PPFP services and antenatal care services, and improve counseling services on PPFP during delivery and postnatal care services.
Perceptions, symptoms, and practices of electronic cigarette users: Descriptive analysis and validation of Arabic short form vaping consequences questionnaire
Authors: Karasneh Reema , Al-Azzam Sayer , Nusair Mohammad , Hawamdeh Sahar 
Published: January 2021

Background
E-cigarette (EC) use is increasing worldwide. Understanding the practices and perceptions of e-cigarette users and profiling the symptoms they experience is essential for regulating the use of such products. This study aims to investigate the practices and perceptions of e-cigarette users in Jordan and examine the symptoms (e.g. respiratory) they associate with e-cigarette use.

Methods
A cross-sectional online survey was conducted to assess EC use and tobacco smoking behaviors and the corresponding health symptoms among EC users in Jordan. EC use expectancies were also assessed using the Short Form Vaping Consequences Questionnaire, which was first translated into Arabic and tested for validity and reliability.

Results
Out of the 400 EC users surveyed, 95.5% were male, 76.2% used nicotine-containing juice, and 56.8% were concurrent tobacco smokers. Further, the participants had a mean age of 28.9 years (±10.2). Among dual EC/cigarette users, 88.6% reported that they tried to quit cigarette smoking, with e-cigarette use being the most commonly tried method of smoking cessation. The smoking-related symptoms reported by regular cigarette smokers mainly included sputum production (77.5%). The participants reported that using e-cigarettes instead of tobacco cigarettes had led to improvements in their sputum production (60.8%), breathing (59%), and general wellbeing (52%). Pleasant taste, enjoyable taste sensation, and flavor were significantly stronger (P-value < 0.05) among e-cigarette users compared to dual users. Dual EC/cigarette users reported stronger perceptions in the negative consequences scale, particularly with regards to the hazardous effects of smoking on health (P-value < 0.05).

Conclusion
Dual daily use of e-cigarettes and regular cigarettes is a common practice among EC users. We recommend that further research is conducted on dual EC/cigarette use and the potential health risks this may have (e.g. higher nicotine intake as compared to the single use of either products).
Malaria and intestinal parasite co-infection and its association with anaemia among people living with HIV in Buea, Southwest Cameroon: A community-based retrospective cohort study
Authors: Mekachie Sandie Sorelle , Sumbele Irene Ule Ngole , Tasah Martin Mih , Kimbi Helen Kuokuo 
Published: January 2021

BackgroundBoth malaria and intestinal parasites are endemic in Cameroon, and their co-infection can be of great impact on anaemia among people living with HIV (PLWH). This community-based retrospective cohort study determined the prevalence and association of infections with anaemia in PLWH and HIV-negative individuals in Buea, Cameroon from March to August 2019.MethodsThe study population comprised of 190 PLWH and 216 consenting HIV-negative individuals from the Buea community. Participants were examined clinically, the collected blood sample was used for malaria parasite (MP) detection, HIV diagnosis and haemoglobin (Hb) measurement while stool samples were examined for the detection of intestinal parasites (IPs). Proportions were compared using Pearson’s Chi-square test and association of anaemia with independent variables was evaluated using logistic regression analysis.ResultsOut of the 406 participants, MP, IPs and MP/IP co-infection prevalences were 15.5%, 13.0% and 3.0% respectively. PLWH had a higher prevalence of MP (16.3%, P = 0.17), IPs (23.7%, P ˂ 0.001) and MP/IPs co-infection (3.7%, P = 0.04) when compared with HIV-negative participants. Similarly, PLWH had significantly lower mean haemoglobin value (11.10 ± 1.54 g/dL) than their HIV-negative counterparts (12.45 ± 2.06 g/dL). Also, PLWH co-infected with MP and IPs were observed to have a significantly lower mean haemoglobin value (10.6 ± 1.21 g/dL). PLWH had a significantly (P ˂ 0.001) higher prevalence of mild (56.8%), moderate (18.4%) and severe (1.6%) anaemia when compared with HIV-negative counterparts. The significant risk factors associated with anaemia included being febrile (P = 0.03), MP-infected only (P = 0.001), HIV-infected only (P < 0.001), having dual (P < 0.001) or triple-infections (P = 0.03).ConclusionMalaria and intestinal parasites remain public health concerns among PLWH and anaemia as a serious haematological abnormality gets exacerbated even with the viral load suppression. Hence, routine medical check-ups among PLWH are recommended.
Social media exposure, risk perception, preventive behaviors and attitudes during the COVID-19 epidemic in La Paz, Bolivia: A cross sectional study
Authors: Zeballos Rivas Diana Reyna , Lopez Jaldin Marinalda Lidia , Nina Canaviri Blanca , Portugal Escalante Luisa Fabiola , Alanes Fernández Angela M. C. , Aguilar Ticona Juan Pablo 
Published: January 2021

Social media has an important role in diffusion of information, during COVID-19 pandemic it could help to promote preventive behaviors, however its role and the pathway is still unclear.ObjectiveTo investigate the association among social media exposure, risk perception, preventive behaviors, and attitudes toward the COVID-19 epidemic in Bolivia.MethodsWe launched an online survey in La Paz and El Alto, Bolivia, during April and May 2020. The questionnaire examined: Socio-demographic factors, Social media use, Risk Perception, Preventive behaviors, attitudes and the willingness to use a vaccine if it were available in the context of the COVID-19 epidemic. A logistic regression was used to evaluate factors associated with risk perception and a structural equation model (SEM) was performed to explore the pathway of the relationship among social media exposure, risk perception and preventive behaviors and attitudes.ResultsAmong 886 participants, the most were young adults, between 18–25 years old (73.4%) and 577 (65.1%) were female. During the the week before the survey 387 (43.7%) reported be exposure to social media Covid-19 information almost always or always. Moreover 304 (34.3%) were categorized as with a high risk perception. The multivariable analyses show that being female (aOR = 1.5, CI 95% 1.1–2.1) and having high exposure to Covid-19 information on social media (aOR = 2.5, CI 95% 1.3–5.3) were associated with a higher risk perception for Covid-19. Furthermore, SEM results indicated that risk perception is associated with the adoption of preventive behaviors and attitudes (β = 0.605, p < 0.001) including the acceptance of a vaccine if one were available (β = 0.388, p < 0.001).ConclusionSocial media exposure to COVID-19 information influences the adoption of preventive attitudes and behaviors through shaping risk perception. Understanding the role of social media during the pandemic could help policymakers and communicators to develop better communication strategies that enable the population to adopt appropriate attitudes and behaviors.
Contar histórias de dunas na escola: o litoral e as mudanças ambientais
Authors: Gaspar de Freitas Joana 
Published: January 2021

Na Faculdade de Letras da Universidade de Lisboa, uma equipa interdisciplinar está a desenvolver um projeto europeu sobre dunas costeiras. Estes ambientes vistos geralmente como simples “montes de areias” são ecossistemas importantíssimos na dinâmica litoral e têm muitas histórias para contar. Com o objetivo de contribuir para a disseminação da ciência e fomentar a educação ambiental, foi proposto aos professores de uma turma do ensino básico a realização de um trabalho conjunto, para abordar o tema das dunas e desenvolver conteúdos que permitam a sua divulgação nas escolas. O que se apresenta neste artigo é justificação dessa proposta e os materiais que vão ser trabalhados. Espera-se que a experiência, depois de testada, possa ser replicada com outras turmas e grupos etários.
At the School of Arts and Humanities of the University of Lisbon (Portugal), an interdisciplinary team is developing a European project on coastal sand dunes. These environments usually seen as simple “piles of sand” are very important coastal ecosystems and have many stories to tell. In order to foster science dissemination and environmental education, it was proposed to the teachers of a high school class to work together with researchers to develop content that allows the diffusion of dunes literacy at schools. This article presents the justification of this proposal and the materials that will be worked. This experience, once tested, is expected to be replicated with other classes and age groups.