bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification and Quantification of MIDD0301 Metabolites
Authors: Roni M.S. Rashid , Zahn Nicolas M. , Mikulsky Brandon N. , Webb Daniel A. , Mian Md Yeunus , Knutson Daniel E. , Guthrie Margaret L. , Cook James M. , Stafford Douglas C. , Arnold Leggy A. 
Published: December 2021

Background:
MIDD0301 is an oral asthma drug candidate that binds GABAA receptors on airway smooth
muscle and immune cells.

Objective:
The objective of this study is to identify and quantify MIDD0301 metabolites in vitro and in vivo and
determine the pharmacokinetics of oral, IP, and IV administered MIDD0301.

Methods:
In vitro conversion of MIDD0301 was performed using liver and kidney microsomes/S9 fractions followed
by quantification using liquid chromatography-tandem mass spectrometry (LC-MS/MS). A LC-MS/MS method was
developed using synthesized standards to quantify MIDD0301 and its metabolites in urine and feces. Blood, lung,
and brain were harvested from animals that received MIDD0301 by oral, IP, and IV administration, followed by LCMS/
MS quantification. Imaging mass spectrometry was used to demonstrate the presence of MIDD0301 in the lung
after oral administration.

Results:
MIDD0301 is stable in the presence of liver and kidney microsomes and S9 fractions for at least two hours.
MIDD0301 undergoes conversion to the corresponding glucuronide and glucoside in the presence of conjugating
cofactors. For IP and IV administration, unconjugated MIDD0301 together with significant amounts of MIDD0301
glucoside and MIDD0301 taurine were found in urine and feces. Less conjugation was observed following oral administration,
with MIDD0301 glucuronide being the main metabolite. Pharmacokinetic quantification of MIDD0301
in blood, lung, and brain showed very low levels of MIDD0301 in the brain after oral, IV, or IP administration. The
drug half-life in these tissues ranged between 4-6 hours for IP and oral and 1-2 hours for IV administration. Imaging
mass spectrometry demonstrated that orally administered MIDD0301 distributes uniformly in the lung parenchyma.

Conclusion:
MIDD0301 undergoes no phase I and moderate phase II metabolism.
Tumor-related Molecular Regulatory Mechanisms of Long Non-coding
RNA RMST: Recent Evidence
Authors: Chen Xuhui , Liu Kai , Xu Wen , Zhou Gang , Yuan Chengfu 
Published: December 2021

Background:
Long non-coding RNA rhabdomyosarcoma 2-associated transcript (LncRNA
RMST) can affect every aspect of tumor progressions, such as proliferation, translocation, and apoptosis.
As a result, RMST can be used as an attractive biomarker for early diagnosis and clinical therapies
of different disease states. This article aims to review pathophysiological functions, molecular
mechanisms as well as promising biotherapies of RMST in multiple tumors.

Methods:
Through the systematic induction and summary of 46 papers published in PubMed concerning
this study, the molecular mechanisms of RMST in all kinds of tumors have been reviewed.

Results:
LncRNA RMST is a tumor-related regulatory mediator, aberrantly expressed in diverse tumors,
including medullary thyroid cancer, hepatocellular carcinoma, endometrial carcinoma, colon
cancer, pancreatic cancer, glioma, Wilm’s tumor, and breast cancer. Furthermore, as a mechanismbased
player, RMST probably guides the translation and post-translation modification, containing
DNA methylation and SUMOylation. It is capable of regulating distinct tumor cells and stem cells of
biological behaviors via various molecular pathways.

Conclusion:
LncRNA RMST, potentially as an original therapeutic target, is valuable in the occurrence,
development, and apoptosis of different tumors.
Pharmacological Targeting of Ferroptosis in Cancer Treatment
Authors: Roushandeh Amaneh Mohammadi , Roudkenar Mehryar Habibi , Valashedi Mehdi Rabiee , Nikoo Amirsadegh , Najafi-Ghalehlou Nima , Tomita Kazuo , Kuwahara Yoshikazu , Sato Tomoaki 
Published: December 2021

:Ferroptosis is a non-apoptotic mode of Regulated Cell Death (RCD) driven by excessive accumulation of toxic lipid peroxides and iron overload. Ferroptosis could be triggered by inhibiting the antioxidant defense system and accumulating iron-dependent Reactive Oxygen Species (ROS) that react with polyunsaturated fatty acids in abundance. Emerging evidence over the past few years has revealed that ferroptosis is of great potential in inhibiting growth and metastasis and overcoming tumor cell resistance. Thus, targeting this form of cell death could be perceived as a potentially burgeoning approach in cancer treatment. This review briefly presents the underlying mechanisms of ferroptosis and further aims to discuss various types of existing drugs and natural compounds that could be potentially repurposed for targeting ferroptosis in tumor cells. This, in turn, will provide critical perspectives on future studies concerning ferroptosis-based cancer therapy.
Ameliorating Alzheimer’s-like Pathology by Minocycline via Inhibiting
Cdk5/p25 Signaling
Authors: Zhao Yu , Wang Chuanling , He Wenbo , Cai Zhiyou 
Published: December 2021

Background:
Minocycline has multiple neuroprotective roles in abundant brain diseases,
including the prevention and treatment of Alzheimer’s disease (AD). Cdk5/p25 signaling plays an
important role in the onset and development of Alzheimer’s-like pathology. The aim of the present
work was to further explore the underlying mechanism by which minocycline exerts its effects on
Cdk5/p25 signaling related to Alzheimer’s-like pathology.

Methods:
The cognitive function of animals was measured by the Morris water maze test. The levels
of Aβ were determined by an enzyme-linked immunosorbent assay. The levels of APP, β- and γ-
secretases, and the biomarkers of tau (total tau and hyperphosphorylated tau), inflammatory cytokine
and matrix metalloproteinases (MMP-2 and MMP-9), and biomarkers of synapse and Cdk5/p25
signaling, were detected by the Western blotting. The biomarkers of the synapse, inflammatory cytokine,
and matrix metalloproteinases (MMP-2 and MMP-9) were also determined by immunofluorescence.

Results:
Minocycline improved learning and memory in APP/PS1 mice. It limited the production of
Aβ and hyperphosphorylation of tau in the hippocampus and ameliorated synaptic deficit. Moreover, it
also inhibited the activation of Cdk5/p25 signaling, inflammation, and matrix metalloproteinases.

Conclusion:
Minocycline mitigates Alzheimer’s-like pathology via limiting the activation of
Cdk5/p25 signaling pathway and improves cognitive deficits.
Neurosteroid Modulation of GABAA Receptor Function by Independent
Action at Multiple Specific Binding Sites
Authors: Wang Lei , Covey Douglas F. , Akk Gustav , Evers Alex S. 
Published: December 2021

:
Neurosteroids are endogenous modulators of GABAA receptors that mediate anxiety,
pain, mood and arousal. The 3-hydroxyl epimers, allopregnanolone (3α-OH) and epiallopregnanolone
(3β-OH) are both prevalent in the mammalian brain and produce opposite effects
on GABAA receptor function, acting as positive and negative allosteric modulators, respectively.
This Perspective provides a model to explain the actions of 3α-OH and 3β-OH neurosteroids. The
model is based on evidence that the neurosteroid epimers bind to an overlapping subset of specific
sites on GABAA receptors, with their net functional effect on channel gating being the sum of their
independent effects at each site.
Effects of a Novel, Transdiagnostic, Hybrid Ecological Momentary Intervention for Improving Resilience in Youth (EMIcompass): Protocol for an Exploratory Randomized Controlled Trial
Authors: Schick Anita , Paetzold Isabell , Rauschenberg Christian , Hirjak Dusan , Banaschewski Tobias , Meyer-Lindenberg Andreas , Boehnke Jan R , Boecking Benjamin , Reininghaus Ulrich 
Published: December 2021

Background
Most mental disorders first emerge in youth and, in their early stages, surface as subthreshold expressions of symptoms comprising a transdiagnostic phenotype of psychosis, mania, depression, and anxiety. Elevated stress reactivity is one of the most widely studied mechanisms underlying psychotic and affective mental health problems. Thus, targeting stress reactivity in youth is a promising indicated and translational preventive strategy for adverse mental health outcomes that could develop later in life and for improving resilience. Compassion-focused interventions offer a wide range of innovative therapeutic techniques that are particularly amenable to being implemented as ecological momentary interventions (EMIs), a specific type of mobile health intervention, to enable youth to access interventions in a given moment and context in daily life. This approach may bridge the current gap in youth mental health care.

Objective
This study aims to investigate the clinical feasibility, candidate underlying mechanisms, and initial signals of the efficacy of a novel, transdiagnostic, hybrid EMI for improving resilience to stress in youth—EMIcompass.

Methods
In an exploratory randomized controlled trial, youth aged between 14 and 25 years with current distress, a broad Clinical High At-Risk Mental State, or the first episode of a severe mental disorder will be randomly allocated to the EMIcompass intervention (ie, EMI plus face-to-face training sessions) in addition to treatment as usual or a control condition of treatment as usual only. Primary (stress reactivity) and secondary candidate mechanisms (resilience, interpersonal sensitivity, threat anticipation, negative affective appraisals, and momentary physiological markers of stress reactivity), as well as primary (psychological distress) and secondary outcomes (primary psychiatric symptoms and general psychopathology), will be assessed at baseline, postintervention, and at the 4-week follow-up.

Results
The first enrollment was in August 2019, and as of May 2021, enrollment and randomization was completed (N=92). We expect data collection to be completed by August 2021.

Conclusions
This study is the first to establish feasibility, evidence on underlying mechanisms, and preliminary signals of the efficacy of a compassion-focused EMI in youth. If successful, a confirmatory randomized controlled trial will be warranted. Overall, our approach has the potential to significantly advance preventive interventions in youth mental health provision.

Trial Registration
German Clinical Trials Register DRKS00017265; https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00017265

International Registered Report Identifier (IRRID)
DERR1-10.2196/27462
Patient Satisfaction and Recommendations for Delivering a Group-Based Intensive Outpatient Program via Telemental Health During the COVID-19 Pandemic: Cross-sectional Cohort Study
Authors: Skime Michelle K , Puspitasari Ajeng J , Gentry Melanie T , Heredia Jr Dagoberto , Sawchuk Craig N , Moore Wendy R , Taylor-Desir Monica J , Schak Kathryn M 
Published: December 2021

Background
Although group-based intensive outpatient programs (IOPs) are a level of care commonly utilized by adults with serious mental illness, few studies have examined the acceptability of group-based IOPs that required rapid transition to a telemental health (TMH) format during the COVID-19 pandemic.

Objective
The aim of this study was to evaluate patient satisfaction and future recommendations for a group-based IOP that was transitioned to a TMH format during the COVID-19 pandemic.

Methods
A 17-item patient satisfaction questionnaire was completed by patients at discharge and covered 3 areas: IOP TMH satisfaction, future recommendations, and video technology challenges. Descriptive and content analyses were conducted for the quantitative and open-ended questions, respectively.

Results
A total of 76 patients completed the program in 2020. A subset of patients (n=40, 53%) responded to the survey at program discharge. The results indicated that the patients were satisfied overall with the TMH program format; 50% (n=20) of the patients preferred the program continue offering the TMH format, and the rest preferred returning to in-person formats after the pandemic. The patients indicated the elements of the program that they found most valuable and provided recommendations for future program improvement.

Conclusions
Overall, adults with serious mental illness reported high satisfaction with the group-based IOP delivered via TMH. Health care systems may want to consider offering both TMH and in-person formats regardless of the state of the pandemic. Patients’ feedback on future improvements should be considered to help ensure long-term success.
Шошоолог: этноним и этническая история
Authors:   Institute for Mongolian, Buddhist and Tibetan Studies, Siberian Branch of the RAS (6, Sakhyanova St., 670047 Ulan-Ude, Russian Federation), Nanzatov Bair Z. , Tishin Vladimir V. 
Published: December 2021

Introduction. This article under takes a study of the clan name Shoshoolog (Šošōlog) in the context of ethnogenesis and ethnic history of the Mongolic and Turkic peoples of Inner Asia and Siberia. New historical and ethnographical data, including the evidence of ethnonymics as a part of the ethnic history of the Mongolic and Turkic peoples of the region will contribute to the knowledge of the migration and settlement history of the Shoshoolog people. The study aims at examining the etymology of the term šošōloγ, the area where it wasspread and theways of itsspread. Data and methods. The authors have taken into account written documents, ethnographical and folklore sources that contained references to the ethnonym in question. The written sources of the period between the seventeenth and nineteenth centuries, mainly in Russian, such as Cossacks’ otpiski (reports), and, more recent, travel and census reports, contain various forms of the ethnonym, often incorrectly spelled but still of interest as evidence pointing at the settlement areas of the ethnic group, as well as a source for linguistic speculation. The ethnographical sources include references to the ethnic group in question based on the legends and sagas shedding light on the people’s origin and settlement patterns both in the Baikal area and in Mongolia. The folklore texts written down by N. N. Poppe, S. P. Baldaev, etc. Include the stories of the Shoshoolog as a Buryat clan with a strong Shamanic background, as well as various forms of the ethnonym. Granted the available knowledge of the historical patterns in the language evolution, the orthographical forms of the ethnonym contained in different records were used as the data for further phonetical reconstructions and localizations of the ethnonym’s phonetic shape in terms of chronological and geographical dimensions. This data, alongside other material on the ethnonymics and onomastics of Mongolic and Turkic peoples, contributes to the linguistic part of the database in the field. Conclusions. A comparative analysis of ethnonymic evidence contained in a variety of sources examined resulted in phonetic reconstructions of the ethnonym under study to finally shed new light on its etymology, as well as to project further developments of its phonetic shape.
A Capacidade Estatal e as demandas da sociedade no contexto da COVID- 19 no setor da educação em Moçambique
Authors: Xavier Zeca Kátia Sara Henriques 
Published: December 2021

Em 1 de Abril de 2020 foi decretado o Estado de Emergência através do decreto Presidencial 11/2020 que estendeu-se até 6 de Setembro de 2020. Através da Resolução n.º 72/2020, de 5 de agosto, o Presidente da República (PR) declarou o estado de emergência para todo o território moçambicano, posteriormente ratificado pela Lei n.º 9/2020, de 7 de agosto. A presente análise intitulada A capacidade estatal e as demandas da sociedade no contexto da covid-19 no setor da educação em Moçambique, tem por objetivo analisar a Capacidade Estatal e resposta do setor da educação no contexto da Pandemia da Covid-19. Em termos metodológicos recorreu-se a analise documental e bilbiográfica em torno da temática em questão. Pode se concluir que o Estado moçambicano tem demonstrado capacidade articuladora e minimizadora para enfrentar os desafios impostos pela Covid-19. A Capacidade Estatal para fazer face a nova dinâmica mostrou-se desafiadora e mantém-se neste processo como entidade primordial para garantir a eficácia e implementação de todas as medidas preventivas. Contudo o que fica em aberto é a capacidade financeira para que estas mesmas medidas possam ser abrangentes e inclusivas, tendo em conta as disparidades no acesso aos recursos e ao bem estar-estar.
Dançando com a solidão: o corpo do palhaço e seus afetos
Authors: Ferreira Andre Luiz Rodrigues 
Published: December 2021

O artigo objetiva investigar a corporeidade na linguagem da palhaçaria, traçando cruzamentos entre a atuação cênica do palhaço e conceitos filosóficos como afectos, afirmação de vida e subjetividade. Esse trabalho parte do diálogo entre conceitos da formação em palhaço e suas possíveis relações com a filosofia deleuzeana. Conclui-se, assim, que a corporeidade do palhaço dinamiza potências e problemáticas que devem ser experienciadas na prática da atuação e do pensamento, instâncias não distintas onde não se pode distinguir entre palhaço e espectador quem afeta e quem é afetado. Palavras-chavePalhaçaria. Corporeidade. Afetos. Afirmação de Vida.
Cartilha Insurgente: por uma pedagogia que atravesse grades
Authors: Marques Laís Jacques , Kunzler Bruna Luana Capelin , Berselli Marcia 
Published: December 2021

Esta cartilha pretende apresentar possíveis intervenções para desestabilizar sistemas que levam ao assujeitamento corporal pessoas consideradas marginalizadas pela estrutura dominante. Observaremos como práticas artísticas (ou práticas criativo-pedagógicas) podem contrapor as opressões cotidianas instauradas em regimes socioeducativos. Como suporte de reflexão, oficinas teatrais e artísticas realizadas em centros de internação, além de autoras e autores com as(os) quais dialogamos em busca de premissas para a ação. Palavras-chaveJuventude em Cárcere. Regime Socioeducativo. Oficinas Artísticas. Pedagogia do Teatro.
Performance no Museu
Authors: Lirio Gurgel Monteiro Gabriela 
Published: December 2021

O artigo é uma reflexão sobre o trabalho realizado com alunos do Programa de Pós-Graduação em Artes da Cena da Universidade Federal do Rio Janeiro e da Escola do Olhar, do Museu de Arte do Rio, a partir de um curso ministrado por mim no Museu. O trabalho é fruto da investigação sobre o Museu das Remoções, espaço de ressignificação e luta pela memória da comunidade da Vila Autódromo, que sofreu um processo de remoção violento visando aos Jogos Olímpicos. Ao entrarmos em contato com imagens, documentos, objetos, narrativas e, sobretudo, com os moradores do local, criamos com a participação da moradora Natália, aluna do curso, uma performance aproximando o espaço urbano e o museológico. Palavras-chavePerformance. Museu. Memória. Vila Autódromo.
Uma Artista em Constante Formação: uma conversa com Sueli Araújo
Authors: Liconti Juliana Lima , Araújo Sueli Cristina Dos Santos 
Published: December 2021

Nesta entrevista, a atriz, diretora e dramaturga da companhia curitibana CiaSenhas de Teatro, Sueli Araújo, fala sobre a sua trajetória artística– os acontecimentos, pessoas, inquietações, aprendizagens, dificuldades e descobertas transformadoras que continuamente a instigam a apostar no encontro e na troca como posicionamento ético-estético-político. Palavras-chaveFormação da Artista Teatral. Processo Criativo. CiaSenhas de Teatro.
Entrevista com Otávio Donasci
Authors: Moran Patricia 
Published: December 2021

Desenhista, cartunista, performer, diretor de arte e com pesquisa poética voltada à tecnologia, Otávio Donasci é conhecido por suas Videocriaturas. Nesta entrevista o artista partilha com o leitor as surpresas e preconceitos experimentados por inventores que se dedicam à manufatura de suas obras. Percorremos sua trajetória pelo teatro, cabaré e eventos de variedades, atrações marcadas pelo humor, visível no aspecto burlesco das Videocriaturas que estrearam em Campos do Jordão integrando a equipe do consagrado Hans-Joachim Koellreutter, compositor atonal e criador do Música Viva. O profícuo percurso de Donasci testemunha mudanças na arte, como a centralidade conquistada pelo corpo e pela performance. Seus experimentos, obra e discurso encarnam uma arqueologia da arte e suas relações com a tecnologia e com o mercado. Palavras chave Performance. Tecnologia. Gambiologia. Teatro. Humor.
AMÉRICA LATINA Y EL CARIBE EN ZONA DE RIESGO: LA PANDEMIA DE COVID-19 Y LA DOCTRINA DEL SHOCK
Authors: Caputto María Carolina 
Published: December 2021

El presente artículo se postula como una advertencia respecto al eventual uso de la situación de crisis provocada -o, mejor dicho, agudizada- por la pandemia de COVID-19 en los países de Latinoamérica y el Caribe, a través de un análisis sustentado en la “doctrina del shock” postulada por la escritoria, periodista y activista canadiense Naomi Klein. Luego de un repaso histórico donde se pueden encontrar sus argumentos, el trabajo analiza por qué motivos interpreto que el derecho humano a la salud de los ciudadanos de nuestra región se encuentra bajo amenaza, en el contexto de la actual pandemia. Para concluir, sostengo y busco justificar que la Bioética de vertiente latinoamericana puede resultar eficaz para abordarla críticamente y con sólidos argumentos humanistas y racionales, alzando la voz en los distintos ámbitos contra toda pretensión de subestimar la calidad de derecho humano del derecho a la salud y, con ello, el rol del Estado como garante de la dignidad de la persona y los derechos fundamentales.
Objects as battlefields in the struggle for civil rights: The archaeology and analysis of contemporary material culture and heritage in Chile
Authors: Goldschmidt Levinsky Dafna , Letelier Cosmelli Javiera 
Published: December 2021

In October of 2019 began, as a manifestation of growing discontent, in Santiago de Chile a movement of social protests popularly known as “Estallido social”. This movement marched against social inequality and high cost of living, targeting the neoliberal system established during the dictatorship of Augusto Pinochet as responsible. Although Chile has been a democracy since 1990, inequality and social injustice has perpetuated in democracy. We reflect on the role of the contemporary objects, their contexts and the position of archaeology in revealing current struggle discourse of civil rights, social diversity and social conflicts. Likewise, we analyze the transformation process of cultural heritage meanings through time, observable both in the appropriation of quotidian objects as way as protest as the resignification of the traditional monuments erected in the city.