bluuebunny/crossref_metadata_2025_split huggingface dataset:
University Legal Learning Spaces Effectiveness in Developing Employability Skills of Future Law Graduates
Authors: Turner Jason James , Amirnuddin Puteri Sofia , Iqbal Singh Harmahinder Singh 
Published: April 2021

Purpose â€“ The objective of this study was to examine the role of legal learning space in a Malaysian university and how this space impacts on law studentsâ€™ preparation for the employment market. This study comes in response to the issue of inexperienced graduates, who lack appropriate employability skills for the world of work, commonly referred to as the â€˜graduate skills gapâ€™. Methodology â€“ This study used an online survey (accessed via a QR code) on 256 law students at a university in Malaysia. The sample size comprised 213 currently enrolled students and 43 alumni, with the former cohort representing 95% of the total law student population at the university and the latter representing 17% of the total alumni population. Findings â€“ The study found that students, regardless of their year of study, did not consider that legal learning space at the university replicated real life legal practice but thought that the space prepared them for employment. The students felt that some legal learning space was better than others in developing their employability skills. Despite this they enjoyed interacting in the space collectively and felt that it helped them improve their teamwork, communication and soft skills. It also revealed that the perceptions of legal learning space could be improved with better management of staff and student expectations. Significance â€“ This study was one of few studies, which investigated the role of learning space in developing law studentsâ€™ employability skills set. The findings helped to consolidate existing research in the area of graduate skills gap, the development of graduate employability skills, and in advancing research on identifying studentsâ€™ perception of learning space and the specific skills students felt they had developed while engaged in this space. This study will be of particular interest to both employers and universities as they seek to manage each otherâ€™s expectations and pursue a more practice-based learning curriculum.
A Meta Analysis on Effective conditions to Offer Animation Based Teaching Style
Authors: Kaushal Rajesh Kumar , Panda Surya Narayan 
Published: April 2021

Purpose - The purpose of this experimental study is to investigate the impact of teaching Oriental Music using Blended Learning (BL) approach for the students of senior secondary level in Sri Lanka specifically focusing on their achievement on required competencies of Oriental Music at Ordinary Level. The study analyzes the academic performance of students with detailed comparison of BL environment and traditional learning environment. Authors propose the application of BL approach to teach Oriental Music and study its impact on improvement of studentsâ€™ competency. The study conducted with the application of a mixed instructional design model of objectivist and constructivist approaches for the design of the blended learning course in a student centred learning environment. Methodology - The study was directed by using true experimental study design with pretest and posttest control groups. BL was applied to the experimental group and the traditional instruction method was applied to control group. 9 schools from Colombo district were randomly selected for the experimental and control groups covering all the three existing school types of Sri Lanka. The study group consisted of 360 students of Grade 10 and Grade 11 who has been studying Oriental Music as a subject for General Certificate of Education Ordinary Level. To analyze the data Descriptive statistics, Paired samples t test, Independent samples t test were utilized. Findings - The findings of the experiment indicated that students who has studied Oriental Music under BL strategy showed a significant improvement in their music academic performances after the intervention. The mean post-test of the experimental group was 71.75 which is significantly higher than the mean control group which was 52.07. The mean difference was 19.68 1.91. Hence, there is a statistically significant increase in the performance of students who studied Oriental Music under blended learning. Thus, it is clearly evident that the blended instruction was effective. Significance - This study indicated a positive platform to mould and cater the entire teaching learning process by introducing BL strategy to Sri Lankan secondary education system and fulfilled an existing research gap by utilizing BL to teach highly traditional abstract art. Results of the study contributes to the curriculum designing field with novel ideas to adapt blended instructions to teach secondary level students effectively.
Enhancing Science Achievement Utilising an Integrated STEM Approach
Authors: Mohd Saat Rohaida , Yaki Akawo Angwal , V. Sathasivam Renuka , Zulnaidi Hutkemri 
Published: April 2021

Purpose â€“ The integrated science, technology, engineering and mathematics (STEM) education has been reported to improve studentsâ€™ science achievement. Nevertheless, few studies have focused on how this approach affected different ability groups. Lack of equity or the presence of achievement gap can be detrimental because they can reduce medium and low-ability studentsâ€™ interest in science, which in turn can affect national development. Thus, the purpose of this study is to determine the main and the interaction effects of integrated science, technology, engineering and mathematics (ISTEMA) on studentsâ€™ science achievement and how this approach affects students with different academic abilities. Methodology â€“ The research adopted a 2x3 factorial design. The sample size consisted of 100 Nigerian science students from Year 11. A total of 51 students with different academic abilities (low, medium and high) were assigned randomly to an experimental group. The experimental group was taught genetics using a fivephased iterative ISTEMA process. Pre-test and post-test data were collected using 40 multiple-choice questions adopted from a national high-stakes examination. Analysis of covariance, paired sample t-test and one-way analysis of variance were utilised in the data analysis. Findings â€“ Findings for research question one revealed a main significant difference in science achievement between year 11 students who learned using ISTEMA and those using traditional methods. No significant interaction effect was observed between the instructional approach and studentsâ€™ academic abilities, that is, studentsâ€™ academic abilities and the instructional approach did not interact to enhance studentsâ€™ achievement. The findings for research question two indicated that high, medium and low academic-ability students benefitted; however, students with low academic abilities had the highest mean gain. Significance â€“ Findings in this study have revealed empirically that the ISTEMA, as an instructional approach, has the potential to close the academic achievement gap. The findings may also serve as a guide for policymakers to promote STEM education in schools.
Teachersâ€™ Practices in the Acquisition of English by Asian Immigrant English Language Learners
Authors: Che Mustafa Mazlina , Md. Radzi Nor Mashitah , Masnan Abdul Halim , Bacotang Juppri , Mohamed Isa Zainiah , Osman Zaharah , Alias Azila 
Published: April 2021

Purpose - The increase in the enrolments of immigrant children in New Zealand seems to have posed great challenges to early childhood education services when it comes to developing the childrenâ€™s English language acquisition. This qualitative case study explored how New Zealand early childhood teachers develop the English language acquisition of Asian immigrant English language learners (ELLs). The theoretical framework of this research drew on a range of sociocultural perspectives, including sociocultural adaptation and acculturation strategies. Methodology - The main participants of this study were seven early childhood teachers and six Asian immigrant ELLs from two early childhood centres. Data on the teachers were collected through observations and semi-structured interviews. For each centre, observations were carried out over a six week period which enabled a series of snapshots of how the teachers developed the English language acquisition of the ELLs. Findings - Making interactions comprehensible for the ELLs is one of the main strategies used by the teachers in developing the acquisition of English language by the ELLs. In the process of teaching the English language to the ELLs, most of the teachers were observed to use certain strategies in making interactions comprehensible for them. The teachers highlighted the strategies and modifications they made in order to make their interactions comprehensible for the ELLs. During the interview, it was clearly seen that with better proficiency in the English language, the communication between the ELLs and their teachers improved. Therefore, the sociocultural adaptation process takes place in a smooth manner for both the ELLs and the teachers. Significance - The central significance of the finding is that through the exploration of New Zealand early childhood teachersâ€™ beliefs and practices, important insights are offered which lead to the improvement of educational practices in early childhood settings for immigrant children in relation to English acquisition. While some of the teachersâ€™ beliefs and practices may have facilitative or positive effects on English acquisition, others may bring debilitative or harmful effects. The findings also add to the existing body of knowledge on teachersâ€™ beliefs and practices in developing English acquisition among the ELLs, particularly Asian children. In the New Zealand early childhood education context, the study provides a platform on how early childhood teachers in New Zealand could develop English acquisition among Asian immigrant ELLs, while valuing and understanding childrenâ€™s cultural backgrounds.
Dimensi Sosial dalam Tafsir Sufistik
Authors: Munshihah Aty 
Published: April 2021

Faiḍ ar-Rahmān fī Tarjama Tafsīr Kalam Malik ad-Dayyān by KH. Shaleh Darat land has been read from a sufitic dimension. However, there is actually a social dimension that has escaped the previous readings. Therefore, this study provides a new perspective in reading the interpretation of KH. Soleh Darat especially in QS. al-Fatihah [1]: 1. This type of research is classified as library research . By using a contextual-sufistic approach, the results of this study are; first , the two characteristics that are in the basmalah pronunciation not only show attributes for Allah but also humans; second , basmalah have social value in it, h al it is illustrated by their compassionate nature that also must be inculcated in ourselves humans themselves (both physical and spiritual) and then applied to the fellow beings by sharing sustenance and mutual reminded in his favor; third, the practice of social life as a symbol that there is God as the Creator.
Wakaf Uang Dalam Pandangan Fikih Muamalat Dan Undang-Undang
Authors: Sultan Antus Nasruddin Mohammad  
Published: April 2021

Penelitian ini menggunakan metode kualitatif bersifat deskriptif. Pengumpulan data berasal dari wawancara kepada pihak yang terikat dengan pengelolaan wakaf uang di Bank CIMB Niaga Syariah serta mengumpulkan data dan mengkaji berbagai sumber tertulis yang terkait dengan praktik wakaf uang di Bank CIMB Niaga Syariah. Hasil penelitian ini menunjukkan bahwa: Praktik wakaf uang yang dilakukan bank CIMB Niaga Syariah adalah Wakif melakukan penyetoran dana wakaf secara langsung maupun tidak langsung melalui program atau jasa layanan di CIMB Niaga Syariah, lalu dana tersebut akan disetorkan ke rekening Giro berakad wadi’ah milik mitra Bank – yaitu Nazhir, kemudian Nazhir akan mengelola dalam bentuk investasi di lembaga keuangan syariah dan mendapatkan bagi hasil yang akan disalurkan kepada mauquf ‘alaih. Bank CIMB Niaga Syariah Dalam tugasnya sebagai LKS PWU, Bank CIMB Niaga Syariah telah melaksanakan tugasnya sesuai dengan Hukum Islam dan Perundang-undangan yang berlaku di Indonesia.
Serial EXTEM, FIBTEM, and tPA Rotational Thromboelastometry Observations in the Maastricht Intensive Care COVID Cohort—Persistence of Hypercoagulability and Hypofibrinolysis Despite Anticoagulation
Authors: Hulshof Anne-Marije , Brüggemann Renée A. G. , Mulder Mark M. G. , van de Berg Tom W. , Sels Jan-Willem E. M. , Olie Renske H. , Spaetgens Bart , Streng Alexander S. , Verhezen Paul , van der Horst Iwan C. C. , Ten Cate Hugo , Spronk Henri M. H. , van Bussel Bas C. T , Henskens Yvonne M. C. 
Published: April 2021

Background: Coronavirus Disease 2019 (COVID-19) patients often present with thromboembolic events. In COVID-19 patients, routine hemostatic assays cannot correctly identify patients at risk for thromboembolic events. Viscoelastic testing with rotational thromboelastometry (ROTEM) might improve the characterization of COVID-19-associated coagulopathy.Objective: To unravel underlying coagulopathy and fibrinolysis over time as measured by serial assessment heparin-independent (FIBTEM and EXTEM) and fibrinolysis illustrating (tissue plasminogen activator; tPA) ROTEM assays.Patients/Methods: Between April 23 and June 12, consecutive adult patients enrolled within the Maastricht Intensive Care COVID (MaastrICCht) cohort were included, and a comprehensive set of clinical, physiological, pharmaceutical, and laboratory variables were collected daily. Twice per week, EXTEM, FIBTEM, and tPA ROTEM were performed. Clotting time (CT), clot formation time (CFT), maximum clot firmness (MCF), lysis onset time (LOT), and lysis time (LT) were determined to assess clot development and breakdown and were compared to routine hemostatic assays.Results: In 36 patients, 96 EXTEM/FIBTEM and 87 tPA ROTEM tests were performed during a 6-week follow-up. CT prolongation was present in 54% of EXTEM measurements, which were not matched by prothrombin time (PT) in 37%. Respectively, 81 and 99% of all EXTEM and FIBTEM MCF values were above the reference range, and median MCF remained elevated during follow-up. The ROTEM fibrinolysis parameters remained prolonged with median LOT consequently &gt;49 min and unmeasurable LT in 56% of measurements, suggesting a severe hypofibrinolytic phenotype.Conclusion: ROTEM tests in COVID-19 ICU patients show hypercoagulability and severe hypofibrinolysis persisting over at least 6 weeks.
Contribution of T Cell Receptor Alpha and Beta CDR3, MHC Typing, V and J Genes to Peptide Binding Prediction
Authors: Springer Ido , Tickotsky Nili , Louzoun Yoram 
Published: April 2021

IntroductionPredicting the binding specificity of T Cell Receptors (TCR) to MHC-peptide complexes (pMHCs) is essential for the development of repertoire-based biomarkers. This affinity may be affected by different components of the TCR, the peptide, and the MHC allele. Historically, the main element used in TCR-peptide binding prediction was the Complementarity Determining Region 3 (CDR3) of the beta chain. However, recently the contribution of other components, such as the alpha chain and the other V gene CDRs has been suggested. We use a highly accurate novel deep learning-based TCR-peptide binding predictor to assess the contribution of each component to the binding.MethodsWe have previously developed ERGO-I (pEptide tcR matchinG predictiOn), a sequence-based T-cell receptor (TCR)-peptide binding predictor that employs natural language processing (NLP) -based methods. We improved it to create ERGO-II by adding the CDR3 alpha segment, the MHC typing, V and J genes, and T cell type (CD4+ or CD8+) as to the predictor. We then estimate the contribution of each component to the prediction.Results and DiscussionERGO-II provides for the first time high accuracy prediction of TCR-peptide for previously unseen peptides. For most tested peptides and all measures of binding prediction accuracy, the main contribution was from the beta chain CDR3 sequence, followed by the beta chain V and J and the alpha chain, in that order. The MHC allele was the least contributing component. ERGO-II is accessible as a webserver athttp://tcr2.cs.biu.ac.il/and as a standalone code athttps://github.com/IdoSpringer/ERGO-II.
Association of Malnutrition, as Defined by the PG-SGA, ESPEN 2015, and GLIM Criteria, With Complications in Esophageal Cancer Patients After Esophagectomy
Authors: Yin Liangyu , Cheng Nian , Chen Ping , Zhang Mengyuan , Li Na , Lin Xin , He Xiumei , Wang Yingjian , Xu Hongxia , Guo Wei , Liu Jie 
Published: April 2021

Background:There are several approaches that can be used for the pre-treatment identification of malnutrition in oncology populations including the Patient-Generated Subjective Global Assessment (PG-SGA), the 2015 consensus statement by the European Society for Clinical Nutrition and Metabolism (ESPEN 2015) and the Global Leadership Initiative on Malnutrition (GLIM).Aims:This study aimed to evaluate whether malnutrition, as defined by these three methods, can be used to predict complications in esophageal cancer (EC) patients after esophagectomy.Methods:We performed a single center, observational cohort study that included 360 EC patients undergoing esophagectomy from December 2014 to November 2019 at Daping Hospital in China. The prevalence of malnutrition in the study population was prospectively defined using the PG-SGA (≥9 defined malnutrition), and retrospectively defined using the ESPEN 2015 and the GLIM. The prevalence of malnutrition and association with postoperative complications were compared in parallel for the three methods.Results:The prevalence of malnutrition before surgery was 23.1% (83/360), 12.2% (44/360), and 33.3% (120/360) in the study population, as determined by the PG-SGA, the ESPEN 2015 and the GLIM, respectively. The PG-SGA and GLIM had higher diagnostic concordance (Kappa = 0.519,P&lt; 0.001) compared to the ESPEN 2015 vs. GLIM (Kappa = 0.361,P&lt; 0.001) and PG-SGA vs. ESPEN 2015 (Kappa = 0.297,P&lt; 0.001). The overall incidence of postoperative complications for the study population was 58.1% (209/360). GLIM- and ESPEN 2015-defined malnutrition were both associated with the total number of postoperative complications in multivariable analyses. Moreover, GLIM-defined malnutrition exhibited the highest power to identify the incidence of complications among all independent predictors in a pooled analysis.Conclusion:Among the PG-SGA, the ESPEN 2015 and the GLIM, the GLIM framework defines the highest prevalence rate of malnutrition and appears to be the optimal method for predicting postoperative complications in EC patients undergoing esophagectomy. These results support the importance of preoperatively identifying malnutrition using appropriate assessment tools, because it can facilitate the selection of management strategies that will optimize the clinical outcomes of EC patients.
Identification of Resectable N2 in NSCLC: A Single Center Experience and Review of the SEER Database
Authors: Wang Yan-qing , Liu Xu-dong , Bai Wen-liang , Li Shan-qing 
Published: April 2021

BackgroundNon-small cell lung carcinoma (NSCLC) with ipsilateral and/or subcarinal mediastinal lymphatic spread (N2) is a heterogeneous disease. The role of surgical resection in patients with N2 NSCLC remains controversial and no survival-based definition of “resectable N2” exists. The purpose of this study is to evaluate the factors that potentially affect the survival of N2 NSCLC patients who receive surgical resection and to define “resectable N2” based on the survival benefits.MethodsData from the open Surveillance, Epidemiology, and End Results (SEER) database from the National Cancer Institute in the United States were used to construct a nomogram. Patients who received surgery between 2010 and 2015 for N2 NSCLC were included. Independent prognostic factors for survival identified through Cox regression analysis were used to create the nomogram. The C-index, receiver operating characteristics (ROC) analyses, calibration curves, and risk stratification were used to evaluate the nomogram. The nomogram was also validated using data from 222 patients from Peking Union Medical College Hospital (PUMCH). Furthermore, lung cancer–related deaths were compared using competitive risk analysis.ResultsIn total, 4267 patients were included in the SEER cohort. Male gender, old age, high T stage and grade, adenosquamous and squamous cell carcinoma, lower lobe and overlapping lesions, extended lobe or bilobectomy and pneumonectomy, no chemotherapy, radiation before and after surgery, positive number of lymph nodes, and lymph node ratio (LNR) were identified as independent risk factors for higher mortality. The nomogram was created using these parameters. The C-index was 0.665 (95% confidence interval (CI), 0.651-0.679) and 0.722 (95% CI, 0.620-0.824) in the SEER and PUMCH cohorts, respectively. The calibration curves showed satisfactory consistency between the predicted and actual survival status in both the SEER and PUMCH cohorts. Competitive risk analysis confirmed that the variables in the nomogram, except radiation, are risk factors for prognosis.Conclusions“Resectable N2” should be assessed by a multidisciplinary team. The novel nomogram developed in this study may help with clinical decision-making for this patient population.
Performance of 18F-DCFPyL PET/CT Imaging in Early Detection of Biochemically Recurrent Prostate Cancer: A Systematic Review and Meta-Analysis
Authors: Sun Jiale , Lin Yuxin , Wei Xuedong , Ouyang Jun , Huang Yuhua , Ling Zhixin 
Published: April 2021

Background: Prostate-specific membrane antigen (PSMA)-targeted 2-(3-{1-carboxy-5-[(6-[18F] fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (18F-DCFPyL) positron emission tomography/computed tomography (PET/CT) has shown advantages in primary staging, restaging, and metastasis detection of prostate cancer (PCa). However, little is known about the role of 18F-DCFPyL PET/CT in biochemically recurrent prostate cancer (BRPCa). Hence, we performed a systematic review and meta-analysis to evaluate 18F-DCFPyL PET/CT as first-line imaging modality in early detection of BRPCa.Methods: A comprehensive literature search of PubMed, Web of Science, Embase, and Cochrane Library was conducted until December 2020. The pooled detection rate on a per-person basis and together with 95% confidence interval (CI) was calculated. Furthermore, a prostate-specific antigen (PSA)-stratified performance of detection positivity was obtained to assess the sensitivity of 18F-DCFPyL PET/CT in BRPCa with different PSA levels.Results: A total of nine eligible studies (844 patients) were included in this meta-analysis. The pooled detection rate (DR) of 18F-DCFPyL PET/CT in BRPCa was 81% (95% CI: 76.9–85.1%). The pooled DR was 88.8% for PSA ≥ 0.5 ng/ml (95% CI: 86.2–91.3%) and 47.2% for PSA &lt; 0.5 ng/ml (95% CI: 32.6–61.8%). We also noticed that the regional lymph node was the most common site with local recurrence compared with other sites (45.8%, 95% CI: 42.1–49.6%). Statistical heterogeneity and publication bias were found.Conclusion: The results suggest that 18F-DCFPyL PET/CT has a relatively high detection rate in BRPCa. The results also indicate that imaging with 18F-DCFPyL may exhibit improved sensitivity in BRPCa with increased PSA levels. Considering the publication bias, further large-scale multicenter studies are warranted for validation.