bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of transcranial direct current stimulation on patients with post stroke fatigue: A study protocol for a double-blind randomized controlled trial
Authors: Sun Weiming , Sun Xing , Dong Xiangli , Yu Guohua , Shuai Lang , Ma Chaolin 
Published: November 2021

Abstract
Introduction Post stroke fatigue (PSF) is an abnormal, persistent, and unexplained physical and psychological tiredness in patients after stroke. It is a common symptom of stroke patients with poor quality of life and bleak prognosis, and the incidence rate is up to 39–72%. It has been widely reported that medicine treatments achieved a lot of progress, there still needs to develop more powerful new strategies to more powerful effect. The transcranial direct-current stimulation (tDCS) shows great potential for the treatment of PSF. This study proposes to apply a double-blind randomized controlled clinical trial to explore the effect and safety of tDCS combined with routine rehabilitation for PSF. Methods and analysis One hundred patients with PSF will be randomly divided into two groups. One of the groups will receive conventional rehabilitation therapy and active tDCS, whereas another group will receive conventional rehabilitation treatment and sham tDCS. Both groups will receive the intervention for 4 weeks, during which time they will undergo either active or sham tDCS 20 minutes a day, 6 days a week. Primary outcome: Fatigue Severity Scale (FSS) will be measured at baseline every weekend during the intervention period. Secondary results: Fatigue Impact Scale (FIS), Functional Assessment Chronic Illness Therapy (Fatigue) (FACIT-F), Specialized Quality of Life Scale in Stroke (SS-QOL) will be measured at baseline and at the end of the intervention time of 4 weeks. Throughout the study, adverse events and adverse reactions will be measured during every treatment. The research study”Effects of transcranial direct current stimulation on patients with post stroke fatigue” has been approved by the Ethics Committee of the First Affiliated Hospital of Nanchang University: Clinical Medicine Ethics Review [2015]043 in Nov, 2015. Discussion This study will provide insight on the efficacy of transcranial direct-current stimulation for post stroke fatigue. This is a double-blind randomized controlled trial whose aim is to assess the effects of tDCS on PSF.This study can provide more information about the treatment of PSF. This study has a period of follow-up, which allows for greater accuracy. It is a single-center trial and this may be a limitation. The other limitation of this study is a relatively small number of participants; thus, the influence of chance on experimental results cannot be completely ruled out. Trial registration number Chinese Clinical Trial Registry,ChiCTR2000031120. Registered on March 22, 2020. This protocol version number is V1.1.
On the order of the non-primes of type 6n+5 and 6n+1
Authors: Wolmersdorfer Christoph 
Published: November 2021

Abstract
The fundamental importance of prime numbers for mathematics is that all other natural numbers can be represented as a unique product of prime numbers[1]. For centuries, mathematicians have been trying to find an order in the occurrence of prime numbers. Since Riemann´s paper on the number of primes under a given size, the distribution of the primes is assumed to be random[2]. Here, I show that prime numbers are not randomly distributed using three parametric sine functions. Their positions are determined by the order of occurrence of the nonprimes of types 6n+5 and 6n+1. Furthermore, I will show an exact primality test using these three parametric sine functions.
Mechanisms generating the numerous hues of chrysanthemum petals can be traced to in vitro γ-ray-induced mutagenesis.
Authors: Din Ambreena , Qadri Zahoor Ahmed , WANI MUNEEB AHMAD , Rather Z.A. , Iqbal Shameen , Malik Sajid Ali , Rafiq Sadaf , Nazki I.T. 
Published: November 2021

Abstract
In terms of global cut flower production, chrysanthemum (Dendranthemum grandiflorum kitam.) ranks among the top ten. When a plant species possesses colour characteristics associated with those of ancestral species, that colour is described as being white, yellow, or pink, with white coloration representing an absence of pigments, and yellow and pink coloration each represents the presence of carotenoids and anthocyanins, respectively. Pigments, or a combination of pigments, have been improved upon to provide an expansive rainbow of floral colours like orange, dark red, purplish-red, and red. Recent green-flowered varieties have developed a reputation for containing chlorophylls in their ray petals. Additionally, transgenic interventions have been used to breed violet/blue flowers. Flower colour is a highly regarded characteristic of any flower cultivar, particularly chrysanthemum. Breeders' ultimate goal is to create newer chrysanthemum cultivars with innovative characteristics, such as new flower colours, using a time and input-efficient approach. Investigating the molecular mechanisms that regulate flower pigmentation may yield critical insights into the rational manipulation of floral colour. To generate a diverse array of flower colour mutants in chrysanthemum cv. “Candid” through mutagenesis, in vitro grown micro shoots were exposed to 10, 20, 30, and 40 Gy gamma irradiation at 100 Gy per minute and were evaluated for different parameters. The rhizogenesis parameters declined with the increase in irradiation dose from 0 Gy to 40 Gy, while as, 10 Gy dose proved to record minimum decline in contrast to the control. Survival, leaf size, and the number of leaves plant-1 after the 8th-week interval exhibited a downward trend with the increasing trend of gamma irradiation dose but recorded a least drop in plants raised from shoots irradiated with 10 Gy gamma irradiation dose with respect to the control. Apparently, the minimum delay in the number of days to floral bud appearance took under 10 Gy compared to control. The highest number of flower colour mutants was recorded under 10 Gy (light pink, orange-pink, white and yellow). Demountable mutation frequency based on flower colour was desirable in plants irradiated with the slightest dose of 10 Gy.
The Effect of Phosphate Binders in Patients With End Stage Kidney Disease Undergoing Hemodialysis: a Prospective Observational Study
Authors: Ge Jie , Mali Niroj , Fan WenXing 
Published: November 2021

Abstract
To compare the clinical efficacy of sevalamer carbonate and lanthanum carbonate in chronic hemodialysis patients. This prospective observational study included 80 patients randomly divided into two groups were followed from December 2019 to December 2020. After 12 months of maintenance hemodialysis treatment with sevalamer carbonate or lanthanum carbonate, serum phosphorus, serum calcium, alkaline phosphatase(ALP), parathyroid hormone (iPTH), low-density lipoprotein(LDL), hemoglobin(HGB), triglycerides(TG) and albumin(ALB) were evaluated. The adequacy of dialysis, the effective rate of treatment and the incidence of adverse reactions were compared as well. After treatment, In lanthanum carbonate group, serum phosphorus and iPTH decreased and albumin increased, the difference was significant(P < 0.05). In sevalamer carbonate group, serum phosphorus and LDL decreased and albumin increased after treatment, the difference was significant(P < 0.05). There was no significant difference in the dialysis adequacy and total effective rate between the two groups (P>0.05). However, the incidence of gastrointestinal adverse reactions in the sevalamer carbonate group was lower than in the lanthanum carbonate group and the difference was significant (P < 0.05). The two phosphate binders are safe and effective for the treatment of hyperphosphatemia in patients with ESKD undergoing maintenance hemodialysis. Nevertheless, sevalamer carbonate seems to be superior with lowering the incidence of gastrointestinal adverse reactions and improving lipid metabolism.
Can Collaborative Innovation Constrain Ecological Footprint? Empirical Evidence From Guangdong-Hong Kong-Macao Greater Bay Area, China
Authors: You Xiaojun , Li Qixiang , Monahan Kyle M. , Fan Fei , Ke Haiqian , Hong Na 
Published: November 2021

Abstract
Constraining ecological footprint (EF) has become an important policy priority to reach the carbon neutrality goal and deal with environmental issues, as it represents the socio-economic pressures on the environment. Current studies on the impact of collaborative innovation (CI) on EF is insufficient, although CI contributes to scientific productivity which benefits the technological progress in clean technology. In addition, seen from different perspectives, whether CI is effective in reducing EF has remain controversial. To further clarify this issue, this paper took Guangdong-Hong Kong-Macao Greater Bay Area (GBA) of China as a case, calculated EF between annual periods of 2008-2018 at the municipal level, measured CI from four dimensions and applied threshold regression models to compare the impact of CI on EF across different economic intervals. The findings showed that: the EF of GBA displayed an overall upward trend with prominent spatial heterogeneity during the study period. The impact of CI on EF presented a double-threshold effect when examined with different indicators. Among which, the flow of scientific personnel and capital boosted EF, which intensified with economic development; while collaboration in technology exerted significant inhibitory effects on EF, and the influence of inter-city knowledge collaboration was limited. This might inspire policymakers to adopt sustainable strategies depending on the type of CI and the economic status of the city to constrain the growth of EF, thus minimizing impacts of human activities on the environment.
Strategic management of the company's value based on the development of innovative and technological activities
Authors: Веселовский М.Я. , Погодина Т.В. 
Published: November 2021

В статье выделены тенденции постиндустриального способа производства и определены особенности их финансирования. Произведена оценка динамической эффективности инновационной деятельности на основе расчета показателя инновационной добавленной стоимости и коэффициента отдачи затрат на инновации в различных отраслях промышленного производства. Выявлены составляющие корпоративной финансовой стратегии и определен механизм обеспечения взаимосвязи между финансовой стратегией и финансовой политикой компании. Сделаны выводы, что необходимо предпринять российским компаниям для обеспечения устойчивого развития и конкурентных преимуществ.
The article highlights the tendencies of the post-industrial mode of production and defines the features of their financing. The assessment of the dynamic efficiency of innovation activity is carried out on the basis ofcalculating the indicator of innovative value added and the rate of return on innovation costs in various industries. The components of the corporate financial strategy are identified and the mechanism for ensuring the relationship between the financial strategy and the financial policy of the company is determined. Conclusions are made of what needs to be done by Russian companies to ensure sustainable development and competitive advantages.
Methodology and problems of collecting initial market information for cadastral valuation of real estate objects
Authors: Осенняя А.В. , Хахук Б.А. , Кушу А.А. , Хушт Н.И. 
Published: November 2021

В статье отмечено, что при формировании модели кадастровой оценки эксперты сталкиваются с необходимостью обработки и анализа больших массивов исходной информации, достаточность и достоверность которых отображает степень соответствия полученной информации реальным показателям рынка и оцениваемых объектов недвижимости, а также возможность их использования для построения адекватной оценочной модели. На основе анализа действующей законодательной и нормативно-правовой базы рассмотрена методология сбора исходной рыночной информации при кадастровой оценке. Выполненные в статье анализ и оценка отчётов и проектов отчётов об итогах государственной кадастровой оценки земельных участков и объектов капитального строительства в составе земель населенных пунктов в регионах страны позволили выявить существующие проблемы, сформулировать пути их решения, а также привести прогноз ожидаемых результатов.
The article notes that when forming a cadastral valuation model, experts are faced with the need to process and analyze large amounts of initial information, the sufficiency and reliability of which reflects the degree of compliance of the information obtained with the real indicators of the market and the estimated real estate objects, as well as the possibility of using them to build an adequate valuation model. Based on the analysis of the current legislative and regulatory framework, the methodology for collecting initial market information for cadastral valuation is considered. The analysis and evaluation of reports and draft reports on the results of the state cadastral assessment of land plots and capital construction projects as part of the lands of settlements in the regions of the country made it possible to identify existing problems, formulate ways to solve them, and also provide a forecast of the expected results.
IMF activities as a provider of financial assistance to the countries affected by the COVID-19 pandemic
Authors: Медведева М.Б. , Хомякова Л.И. , Зверева А.Д. 
Published: November 2021

В целях поддержки стран по преодолению экономических последствий пандемии COVID-19 МВФ выделил им финансовые ресурсы и предоставил инструменты облегчения обслуживания долга в рамках различных механизмов кредитования и финансирования. Программа действует с конца марта 2020 года. В статье отмечено, что МВФ быстро отреагировал на чрезвычайную ситуацию, вызванную пандемией, и развернул широкую программу помощи странам с низким уровнем дохода в целях преодоления ее последствий.
The IMF provides financial assistance and debt relief under various lending and financing mechanisms to member countries facing the economic fallout from the COVID-19 pandemics. The article provides an overview of the assistance approved by the IMF since the end of March 2020. It was noted that the IMF quickly responded to the emergency caused by the pandemic and launched an extensive program of assistance to low-income countries in order to overcome its consequences.
Development of control processes of research and production subsystems at scientific enterprises of rocket and space engineering
Authors: Барковская В.Е. , Абрашкин М.С. 
Published: November 2021

В статье уточнено влияние процессов управления научно-исследовательской и производственной подсистемами наукоёмких предприятий РКМ на эффективность их развития. Доказано с использованием методов логико-абстрактного моделирования, что сложившаяся организационно-экономическая структура наукоёмких предприятий РКМ не совершенна и требует изменения управления научно-исследовательской и производственной подсистемами, совокупность которых за счёт синергетического эффекта, проявляемого во внутриорганизационной и межорганизационной интеграции, позволит дать оценку общей эффективности их развития. Проведен анализ показателей наукоемкости предприятий РКМ, который установил, что целесообразна их научно-производственная интеграция в пространственных моделях, внедрение и использование технологических платформ.
The article specifies R&D and production management process upon knowledge-intensive rocket and space enterprises in respect or their development effectiveness. It is approved with the method of abstract logical modeling that contemporary organization and economic structure of the knowledge-intencive enterprises has to be modified in terms of R&D and production subsystem management. Both of them will lead to increase development by synergetic effect caused by inter- and cross- organization integration. The analysis of the indicators of the science intensity of enterprises of the knowledge-intensive rocket and space enterprises was carried out, it was established that their scientific and industrial integration in spatial models, the introduction and use of technological platforms is expedient.
Software Applications as an Ensuring Means the Quality of Service the Wi-Fi networks
Authors: Шевелев С.В. , Семенов А.Б. 
Published: November 2021

Рассмотрены принципы обеспечения заданного уровня качества обслуживания QoS в беспроводных сетях, позволяющие достигнуть устойчивого функционирования программных приложений реального времени за счет тонкой настройки приоритезации генерируемого ими трафика. Основное внимание уделяется механизму управления доступом на основе конкуренции и контролируемого доступа, а также их расширениям. Затронуты вопросы инкапсуляции базовых механизмов управления в решения более высоких уровней EDCA и TXOP. Приведены расчетные значения соответствующих параметров.
The principles of ensuring a given level of quality of QoS service in wireless networks are considered, which allow achieving the stable functioning of real-time software applications by fine-tuning the prioritization of the traffic generated by them. The main focus is on the competition-based access control mechanism and controlled access, as well as their extensions. The issues of encapsulation of basic control mechanisms in solutions of higher levels of EDCA and TXOP are touched upon. The calculated values of the corresponding parameters are given.
Investigation of the possibility of improving the performance of rolling bearings using metal-coating nanotechnologies
Authors: Прокопенко А.К. , Попов С.А. , Корнеев А.А. 
Published: November 2021

Проведены исследования по повышению износостойкости трущихся деталей подшипника качения за счет использования металлоплакирующих нанотехнологий в процессе обкатки и эксплуатации. Приведены результаты лабораторных триботехнических испытаний подшипниковых материалов в режиме металлоплакирования. Показан механизм образования защитной пленки на стальной поверхности деталей подшипника качения. Экспериментальным путем подтверждена возможность увеличения ресурса подшипников качения в процессе эксплуатации.
Studies have been carried out to increase the wear resistance of the friction parts of the rolling bearing due to the use of metal-coating nanotechnologies in the process of running-in and operation. The results of laboratory tribotechnical tests of bearing materials in the metal plating mode are presented. The mechanism of formation of a protective film on the steel surface of rolling bearing parts is shown. The possibility of increasing the service life of rolling bearings during operation has been experimentally confirmed.
Ccuracy of measurement of the information parameter of the signal by a tracking meter in aviation and rocket and space technology against the background of additive and multiplicative interference. The spectral density of the discriminator output signal. Part II
Authors: Артюшенко В.М. , Воловач В.И. 
Published: November 2021

Рассмотрено и проанализировано влияние мультипликативных помех, действующих одновременного с аддитивными помехами, на точность измерения одного информационного параметра следящим измерителем. Проанализирована спектральная плотность выходного сигнала дискриминатора .
The influence of multiplicative interference acting simultaneously with additive interference on the accuracy of measurement of one information parameter by a tracking meter is considered and analyzed. The spectral density of the discriminator output signal is analyzed .
Equipment selection criteria for increasing the durability of printed circuit boards of on-board radio telemetry systems
Authors: Мороз А.П. , Скворцов Р.В. 
Published: November 2021

Рассматривается критерий задачи корректного выбора типа оборудования для устранения причин возникновения соответствующих видов дефектов многослойных печатных плат бортовых радиотелеметрических систем на этапе производства. Ограничением является объем выделяемых на это средств.
The criterion of the problem of the correct choice of the type of equipment to eliminate the causes of the corresponding types of defects of multilayer printed circuit boards of on-board radio telemetry systems at the production stage is considered. The limit is the amount of funds allocated for this purpose.
O ENSINO DE HISTÓRIA E EDUCAÇÃO PATRIMONIAL NA EDUCAÇÃO BÁSICA: DESAFIOS E POSSIBILIDADES
Authors: Malverdes Clara Zandomenico , Salim Maria Alayde Alcantara 
Published: November 2021

Este artigo tem como objetivo apresentar uma pesquisa participante que contou com uma intervenção e aplicação de uma metodologia chamada “Imaginando”, cujo princípio foi a utilização da linguagem fotográfica na representação do conceito de patrimônio. Para isso, inicialmente são apresentados estudos da área que investigaram a ampliação do conceito de fontes na produção historiográfica brasileira e a relação entre o ensino de história e a educação patrimonial no âmbito dos anos iniciais apresentando problemas e possíveis possibilidades de intervenções pedagógicas. O estudo contou com a participação de 22 alunos de uma turma de 5º ano do ensino fundamental de uma escola pública localizada no município de Serra, Espírito Santo. As atividades se desenvolveram ao longo de um mês, distribuídas em uma aula por semana. Após a análise dos instrumentos produzidos e utilizados é possível afirmar que as fotografias possuem funções comunicativas, e que, no contexto investigado constatou-se a possibilidade do uso da imagem fotográfica como fonte histórica escolar, a qual contribuiu de forma significativa para a organização do conceito e a compreensão do conteúdo.
EDUCAÇÃO ALIMENTAR E NUTRICIONAL: ANÁLISE DE AÇÕES COM ADULTOS A PARTIR DO MARCO DE REFERÊNCIA
Authors: Giusti Lisiane , Sander Scarparo Ana Luiza , Nicolodi Francescato Ruiz Eliziane 
Published: November 2021

O presente trabalho objetivou revisar e analisar produções brasileiras sobre intervenções de Educação Alimentar e Nutricional com adultos após a criação do Marco de Referência de Educação Alimentar e Nutricional para Políticas Públicas. Realizou-se uma revisão da produção científica considerando como critérios de elegibilidade: intervenções de educação alimentar e nutricional, público alvo de adultos e ações/intervenções realizadas entre o período de 2012 a 2018. Para a análise utilizaram-se os seguintes elementos: o objetivo das ações de EAN, o público-alvo, a metodologia utilizada e os principais resultados dos estudos, a presença dos princípios do Marco de EAN nas intervenções realizadas nos estudos e uso de abordagens e recursos educacionais problematizadores e ativos, que favorecessem o diálogo entre os participantes. Foram encontrados 82 artigos e destes selecionaram-se 10 artigos que responderam aos critérios de elegibilidade. Identificou-se que nove dos estudos apresentaram uma abordagem relacionada com um ou mais dos princípios do Marco. Porém, nenhum dos trabalhos analisados utilizou diretamente o Marco de EAN como referência na descrição metodológica ou o utilizou como uma base teórica. Além disso, somente quatro dos estudos analisados realizaram as ações com o uso de abordagens e recursos educacionais problematizadores e ativos que favorecessem o diálogo entre os participantes. Com isso, destaca-se a necessidade de construção de novas perspectivas para as práticas de educação alimentar e nutricional e a necessidade de aperfeiçoar os estudos com a utilização do Marco como referência.