bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of complementary feeding practices among children aged 6–23 months in five countries in the Middle East and North Africa region
Authors: Shaker‐Berbari Linda , Qahoush Tyler Vilma , Akik Chaza , Jamaluddine Zeina , Ghattas Hala 
Published: June 2021

AbstractEnsuring diets of children aged 6–23 months meet recommended guidance is crucial for growth and development and for the prevention of malnutrition including stunting, wasting and micronutrient deficiencies. Despite some improvement, indicators related to undernutrition and overnutrition fall short of global targets in the Middle East and North Africa (MENA) region that consist of low‐ and middle‐income countries witnessing political and social changes and a nutrition transition. This research aims at reviewing the situation related to the diets of children aged 6–23 months in five selected countries in the MENA region, examining factors affecting complementary feeding and providing recommendations for guiding effective strategies to improve it. The study triangulated data on complementary feeding status and predictors from semistructured interviews with 30 key informants, and multivariable analysis of household surveys in Egypt, Jordan, Lebanon, State of Palestine and Sudan including data on refugees in Lebanon and Jordan. There remain considerable gaps in complementary feeding differing noticeably among geographic areas. Findings from qualitative and quantitative analyses showed that maternal factors, including maternal education and age, household level factors such as paternal education and wealth, community‐level factors (culture and geographic location), and utilization of health services, were associated with minimum dietary diversity (MDD), minimum meal frequency (MMF) and minimum acceptable diet (MAD) at varied levels in the five countries. Interventions to improve complementary feeding practices should include actions tailored to the needs of the population at multiple levels including at the caregiver's level, household, service use, community and policy level.
Typicality and volition as fundamental features of everyday relational communication
Authors: Hall Jeffrey A. , Mihailova Teodora , Merolla Andy J. 
Published: June 2021

AbstractDrawing from communicate bond belong theory, two dimensions of routine social interactions (i.e., volition, typicality) are examined in the context of everyday talk to advance theory on relationship maintenance. Adults' (N = 127) social interactions (n = 2537) were collected using experience sampling. Testing preregistered hypotheses, multilevel modeling results suggest that in more typical interactions individuals reported more connection and well‐being and less social energy expenditure. The more volitional (i.e., engaged in by choice) the interaction, the more the connection and well‐being and the more the social energy expended. Day‐over‐day analyses (n = 793) suggest that participants maintained their relationships more easily when they had more choice in their interactions each day but a more stable routine of interaction across the week.
Whole multiple location and universals
Authors: Giberman Daniel 
Published: June 2021

AbstractAccording to the broadly Aristotelian distinction between universals and particulars, all and only the former are capable of whole multiple location. The present essay defends this distinction against four putative counterexamples. The first two, extended simple material objects and enduring time‐traveling self‐meeters, putatively are wholly multiply locatable, but not universals. The second two, unique properties of point‐sized entities and Platonic (i.e., not spatiotemporally located) universals, putatively are universals, but not wholly multiply locatable. The defensive strategy is to resist certain presuppositions underlying the examples.
The phylogeny of robber flies (Asilidae) inferred from ultraconserved elements
Authors: Cohen Chris M. , Noble Katherine , Jeffrey Cole T. , Brewer Michael S. 
Published: June 2021

ABSTRACTRobber or assassin flies (Asilidae) are a diverse family of venomous predators. The most recent classification organizes Asilidae into 14 subfamilies based on a morphological phylogeny, but many of these are not supported by molecular data. To test the monophyly of various clades in Asilidae, we used the recently developed Diptera‐wide ultraconserved element bait set to compile seven datasets comprising 151 robber flies and 145–2496 loci. We also compared the performance of various nodal support metrics. Our Maximum Likelihood phylogeny was fully resolved and well supported, but partially incongruent with the coalescent phylogeny. Further examination of datasets suggested that GC bias had influenced gene tree inference and subsequent species tree analyses. The subfamilies Brachyrhopalinae, Dasypogoninae, Dioctriinae, Stenopogoninae, Tillobromatinae, Trigonomiminae and Willistonininae were not recovered as monophyletic. The inter‐subfamily relationships are summarized as follows: Laphriinae and Dioctriinae (in part) successively sister to the remaining subfamilies, which form two clades: the first consists of a grade of Stenopogoninae (in part), Willistonininae (in part), Bathypogoninae+Phellinae, Stichopogoninae, Leptogastrinae, Ommatiinae and Asilinae; the second clade consists of a paraphyletic assemblage of genera from Dioctriinae (in part), Trigonomiminae, Stenopogoninae (in part), Tillobromatinae, Brachyrhopalinae and Dasypogoninae. This phylogeny demonstrates that the higher classification of Asilidae is far from settled, but does provide a much‐needed foundation for a thorough revision of the subfamily classification.
Systematic review and meta‐analysis of integrated studies on antimicrobial resistance genes in Africa—A One Health perspective
Authors: Escher Nora A. , Muhummed Abdifatah M. , Hattendorf Jan , Vonaesch Pascale , Zinsstag Jakob 
Published: June 2021

AbstractBackgroundIncreasing antimicrobial resistance (AMR) raises serious health and financial concerns. However, the main drivers of the emergence, spread and subsequent colonisation of resistant bacterial strains between humans, animals and the environment are still poorly understood.ObjectiveThe aim of this review was to identify molecular studies on AMR in One Health settings in Africa and to determine the prevalence of antimicrobial resistance genes in humans, animals and the environment. Due to the very low number of studies including environmental samples, the meta‐analysis only includes data obtained from animals and humans.MethodsThe PubMed, Web of Science and Scopus databases were searched, identifying 10 464 publications on AMR in Africa from January 1st, 2000 until June 1st, 2020. Inclusion criteria were: (i) Integrated studies assessing AMR simultaneously in an animal‐human, animal‐environment, human‐environment or animal‐human‐environment context, (ii) Genotypic characterisation of AMR and (iii) temporal and spatial relationship between samples from humans and animals. Statistical random‐effects model meta‐analysis was performed.ResultsOverall, 18 studies met our eligibility criteria and were included in this review. Six studies investigated Escherichia coli and Salmonella spp. (N = 6). The most prevalent AMR genes in animals included sul1 (36.2%), sul2 (32.0%), tetA (31.5%), strB (30.8%) and blaTEM (30.0%), whereas sul2 (42.4%), tetA (42.0%), strB (34.9%), blaTEM (28.8%) and sul1 (27.8%) were most prevalent in humans. We observed no clear pattern for a higher prevalence in either the animal or the human reservoir.ConclusionTo date, data on AMR in a One Health perspective in Africa are scarce. Prospective and longitudinal studies using an integrated One Health approach assessing the environment, animals and humans at the same time are needed to better understand the main drivers of AMR sharing in Africa.
Bilinear Systems With Initial Gaps Involving Inelastic Collision: Forced Response Experiments and Simulations
Authors: Noguchi Kohei , Saito Akira , Tien Meng-Hsuan , D’Souza Kiran 
Published: June 2021

Abstract
In this paper, the forced response of a two degrees-of-freedom (DOF) bilinear oscillator with initial gaps involving inelastic collision is discussed. In particular, a focus is placed upon the experimental verification of the generalized bilinear amplitude approximation (BAA) method, which can be used for the accurate estimation of forced responses for bilinear systems with initial gaps. Both experimental and numerical investigations on the system have been carried out. An experimental setup that is capable of representing the dynamics of a 2DOF oscillator has been developed, and forced response tests have been conducted under swept-sine base excitation for different initial gap sizes. The steady-state response of the system under base excitation was computed by both traditional time integration and BAA. It is shown that the results of experiments and numerical predictions are in good agreement especially at resonance. However, slight differences in the responses obtained from both numerical methods are observed. It was found that the time duration where the DOFs are in contact with each other predicted by BAA is longer than that predicted by time integration. Spectral analyses have also been conducted on both experimental and numerical results. It was observed that in a frequency range where intermittent contact between the masses occurs, super-harmonic components of the excitation frequency are present in the spectra. Moreover, as the initial gap size increases, the frequency band where the super-harmonic components are observed decreases.
Transient Vibroacoustic Analysis of Functionally Graded Plates
Authors: Pandey Avnish Mahendra , Nagendra Gopal K. V. 
Published: June 2021

Abstract
This paper presents the vibroacoustic response of pure functionally graded (FG) plates under transient loading of mechanical nature. The functionally graded plate is modeled using the conventional first-order shear deformation theory (FSDT) to incorporate the effects of transverse shear and rotary inertia. The mid-surface variables are determined using the finite element method. Transient structural response is determined using Newmark Beta time marching scheme and the acoustic pressure in the free field is obtained using the time-domain Rayleigh integral. The effective material properties of the FG plate and the transient response of both the structural and acoustic fields have been computed in matlab. The influence of the volume fraction index, thickness ratio, and boundary conditions of pure FG plate on its transient vibroacoustic response is investigated by a detailed parametric study.
Recovery of the Two-Dimensional Ion Distribution Function in a Magnetic Mirror from Measurements of Collective Thomson Scattering Spectra
Authors: Gospodchikov E. D. , Khusainov T. A. , Shalashov A. G. 
Published: June 2021

Abstract
A method is proposed for tomography of the distribution function of energetic ions that are adiabatically trapped in an open magnetic trap, according to the diagnostic data by the method of collective Thomson scattering. This method is based on measurements of the scattering spectra from successive plasma cross sections corresponding to different values of the magnetic-field strength along a single line of force. It is shown that the problem of restoring the ion distribution function in the velocity space from the measurement data in this situation is reduced to an integral equation of the first kind that allows an analytical solution. Several ways to construct exact and approximate solutions of the resulting integral equation are considered.
Endovascular middle cerebral artery embolic stroke model: a novel approach
Authors: Gonzalez L Fernando , Warner David S , Sheng Huaxing , Chaparro Eduardo 
Published: June 2021

A video (video 1) describing a novel murine endovascular embolic stroke model is presented. Traditional middle cerebral artery (MCA) occlusion models include a blind insertion of a monofilament string1 2 into the common or external carotid artery with the expectation to selectively occlude the MCA. However, significant mortality occurs due to subarachnoid hemorrhage and variability in stroke size, possibly related to the filament’s malposition—for example, external carotid or proximal internal carotid artery (ICA). Additionally, while the string is in place, it occludes the entire extracranial ICA affecting also the collateral pial circulation.Video 1Our model includes tail artery access, which tolerates several procedures facilitating survival studies. This model uses autologous blood3 4 clot deployed directly into the MCA, resembling what occurs in clinical practice. Autologous thrombi could be lysed with IA/IV tissue plasminogen activator.In summary, we describe a novel model that resembles real practice, permits multiple catheterizations, results in reliable embolization under fluoroscopic guidance and allows therapeutic interventions not available with traditional models.
Impact of Prediabetes and Type-2 Diabetes on Outcomes in Patients with COVID-19
Authors: Makker Jasbir , Sun Haozhe , Patel Harish , Mantri Nikhitha , Zahid Maleeha , Gongati Sudharsan , Galiveeti Sneha , Renner Sharon W. , Chilimuri Sridhar 
Published: June 2021

Introduction. The true impact of prediabetes and type-2 diabetes in patients with COVID-19 remains unknown, with studies thus far providing conflicting evidence. Methods. This is a single-center retrospective observational study involving 843 hospitalized patients with SARS-CoV-2 infection. Primary outcomes, mortality, and mechanical ventilation use were compared among the three groups: control, prediabetes, and type-2 diabetes. Binomial regression analysis was used to determine predictors of mortality and mechanical ventilation requirement. Results. Age was a significant predictor of mortality. On stratifying our patients based on their age, older patients aged 55 years and above had no difference in mortality or mechanical ventilation requirement among the three groups of control, prediabetes, and type-2 diabetes. However, among the younger population aged less than 55 years, patients with type-2 diabetes had significantly higher mortality as compared with patients in control and prediabetes groups (27% vs 12.5% vs 9%,

p

0.025

). Additionally, newly diagnosed type-2 diabetes patients demonstrated lower mortality rate in comparison to previously known type-2 diabetes patients (18% vs 40%,

p

0.005

). Outcomes in the prediabetes group were similar to that in the control group. Admission hyperglycemia was associated with higher mortality regardless of diabetes status. Conclusion. In older patients aged 55 years and above, status of type-2 diabetes does not influence their mortality. However, in younger patients aged less than 55 years, the presence of type-2 diabetes is an important driver of mortality. Newly diagnosed type-2 diabetes, in comparison with previously diagnosed type-2 diabetes, may have better survival. Presence of prediabetes did not affect outcomes in patients with COVID-19 infection.
A Phase I Study of APX005M and Cabiralizumab with or without Nivolumab in Patients with Melanoma, Kidney Cancer, or Non–Small Cell Lung Cancer Resistant to Anti-PD-1/PD-L1
Authors: Weiss Sarah A. , Djureinovic Dijana , Jessel Shlomit , Krykbaeva Irina , Zhang Lin , Jilaveanu Lucia , Ralabate Amanda , Johnson Barbara , Levit Neta Shanwetter , Anderson Gail , Zelterman Daniel , Wei Wei , Mahajan Amit , Trifan Ovid , Bosenberg Marcus , Kaech Susan M. , Perry Curtis J. , Damsky William , Gettinger Scott , Sznol Mario , Hurwitz Michael , Kluger Harriet M. 
Published: June 2021

Abstract

Purpose:
PD-1/PD-L1 inhibitors are approved for multiple tumor types. However, resistance poses substantial clinical challenges.

Patients and Methods:
We conducted a phase I trial of CD40 agonist APX005M (sotigalimab) and CSF1R inhibitor cabiralizumab with or without nivolumab using a 3+3 dose-escalation design (NCT03502330). Patients were enrolled from June 2018 to April 2019. Eligibility included patients with biopsy-proven advanced melanoma, non–small cell lung cancer (NSCLC), or renal cell carcinoma (RCC) who progressed on anti-PD-1/PD-L1. APX005M was dose escalated (0.03, 0.1, or 0.3 mg/kg i.v.) with a fixed dose of cabiralizumab with or without nivolumab every 2 weeks until disease progression or intolerable toxicity.

Results:
Twenty-six patients (12 melanoma, 1 NSCLC, and 13 RCC) were enrolled in six cohorts, 17 on nivolumab-containing regimens. Median duration of follow-up was 21.3 months. The most common treatment-related adverse events were asymptomatic elevations of lactate dehydrogenase (n = 26), creatine kinase (n = 25), aspartate aminotransferase (n = 25), and alanine aminotransferase (n = 19); periorbital edema (n = 17); and fatigue (n = 13). One dose-limiting toxicity (acute respiratory distress syndrome) occurred in cohort 2. The recommended phase 2 dose was APX005M 0.3 mg/kg, cabiralizumab 4 mg/kg, and nivolumab 240 mg every 2 weeks. Median days on treatment were 66 (range, 23–443). Median cycles were 4.5 (range, 2–21). One patient had unconfirmed partial response (4%), 8 stable disease (31%), 16 disease progression (62%), and 1 unevaluable (4%). Pro-inflammatory cytokines were upregulated 4 hours post-infusion. CD40 and MCSF increased after therapy.

Conclusions:
This first in-human study of patients with anti-PD-1/PD-L1–resistant tumors treated with dual macrophage-polarizing therapy, with or without nivolumab demonstrated safety and pharmacodynamic activity. Optimization of the dosing frequency and sequence of this combination is warranted.
Real-world Experience of Olaparib Treatment in Patients with Ovarian Cancer: A Chinese Multicenter Study
Authors: Zheng Hong , Gao Yunong , Guo Hongyan , Li Li , Li Qingshui , Cui Heng , Lin An , Sun Lixin , Hu Yuanjing , Kang Shan , Duan Wei , Pan Lingya , Wang Shuzhen , Yang Yingjie , Li Yunxia , Kong Weimin , Xiang Yang , Tian Xiaofei , Ling Bin , Ha Chunfang , Bai Wenpei 
Published: June 2021

Abstract
The objective of this study was to evaluate the real-world application, efficacy, and safety data of olaparib for maintenance therapy and active treatment in patients with ovarian cancer in China. Patients with ovarian cancer from 17 institutions in China treated with olaparib as maintenance or active therapy from January 2018 to March 2020 were included in this study. The medical records were reviewed, and follow-up information was collected for analysis of the patients' clinicopathologic characteristics as well as the effectiveness and safety of olaparib. A total of 251 patients receiving olaparib were included, with 84 as maintenance therapy after first-line chemotherapy (FL-M), 97 as maintenance therapy after platinum-sensitive recurrence (PSR-M), and 70 as active treatment (AT). The probability of progression-free survival (PFS) at 12 months was 87.6% in the FL-M group and 63.8% in the PSR-M group. According to the multivariate analysis, complete response (CR) to chemotherapy for the PSR-M patients was the only factor affecting the PFS (HR = 0.414, P = 0.014), and platinum sensitivity was the only factor affecting PFS improvement in the AT group (HR = 0.317, P = 0.009). In the AT group, the objective response rate was 37.1%, the CR rate was 7.1%, and 30% of the patients had stable disease. Eight (3.2%) patients discontinued olaparib due to toxicity. Anemia was the most common adverse event. In conclusion, olaparib is effective and well tolerated in the real-world setting of ovarian cancer treatment. Platinum sensitivity is positively correlated to the effectiveness of olaparib in both maintenance and active treatment.
VLX600 Disrupts Homologous Recombination and Synergizes with PARP Inhibitors and Cisplatin by Inhibiting Histone Lysine Demethylases
Authors: Ekstrom Thomas L. , Pathoulas Nicholas M. , Huehls Amelia M. , Kanakkanthara Arun , Karnitz Larry M. 
Published: June 2021

Abstract
Tumors with defective homologous recombination (HR) DNA repair are more sensitive to chemotherapies that induce lesions repaired by HR as well as PARP inhibitors (PARPis). However, these therapies have limited activity in HR-proficient cells. Accordingly, agents that disrupt HR may be a means to augment the activities of these therapies in HR-proficient tumors. Here we show that VLX600, a small molecule that has been in a phase I clinical trial, disrupts HR and synergizes with PARPis and platinum compounds in ovarian cancer cells. We further found that VLX600 and other iron chelators disrupt HR, in part, by inhibiting iron-dependent histone lysine demethylases (KDM) family members, thus blocking recruitment of HR repair proteins, including RAD51, to double-strand DNA breaks. Collectively, these findings suggest that pharmacologically targeting KDM family members with VLX600 may be a potential novel strategy to therapeutically induce HR defects in ovarian cancers and correspondingly sensitize them to platinum agents and PARPis, two standard-of-care therapies for ovarian cancer.
β-Catenin Attenuation Inhibits Tumor Growth and Promotes Differentiation in a BRAFV600E-Driven Thyroid Cancer Animal Model
Authors: Zou Minjing , BinEssa Huda A. , Al-Malki Yousif H. , Al-Yahya Suhad , Al-Alwan Monther , Al-Jammaz Ibrahim , Khabar Khalid S.A. , Almohanna Falah , Assiri Abdullah M. , Meyer Brian F. , Alzahrani Ali S. , Al-Mohanna Futwan A. , Shi Yufei 
Published: June 2021

AbstractBRAFV600E mutation is the most frequent genetic alteration in papillary thyroid cancer (PTC). β-Catenin (Ctnnb1) is a key downstream component of canonical Wnt signaling pathway and is frequently overexpressed in PTC. BRAFV600E-driven tumors have been speculated to rely on Wnt/β-catenin signaling to sustain its growth, although many details remain to be elucidated. In this study, we investigated the role of β-catenin in BrafV600E-driven thyroid cancer in a transgenic mouse model. In BrafV600E mice with wild-type (WT) Ctnnb1 (BVE-Ctnnb1WT or BVE), overexpression of β-catenin was observed in thyroid tumors. In BrafV600E mice with Ctnnb1 knockout (BVE-Ctnnb1null), thyroid tumor growth was slowed with significant reduction in papillary architecture. This was associated with increased expression of genes involved in thyroid hormone synthesis, elevated 124iodine uptake, and serum T4. The survival of BVE-Ctnnb1null mice was increased by more than 50% during 14-month observation. Mechanistically, downregulation of MAPK, PI3K/Akt, and TGFβ pathways and loss of epithelial–mesenchymal transition (EMT) were demonstrated in the BVE-Ctnnb1null tumors. Treatment with dual β-catenin/KDM4A inhibitor PKF118–310 dramatically improved the sensitivity of BVE-Ctnnb1WT tumor cells to BRAFV600E inhibitor PLX4720, resulting in significant growth arrest and apoptosis in vitro, and tumor regression and differentiation in vivo. These findings indicate that β-catenin signaling plays an important role in thyroid cancer growth and resistance to BRAFV600E inhibitors. Simultaneously targeting both Wnt/β-catenin and MAPK signaling pathways may achieve better therapeutic outcome in BRAFV600E inhibitor-resistant and/or radioiodine-refractory thyroid cancer.