bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term outcomes for 2-stage urethroplasty: an analysis of risk factors for urethral stricture recurrence
Authors: Furr James R. , Wisenbaugh Eric S. , Gelman Joel 
Published: April 2021

Abstract
Purpose
To report long-term results and patient reported outcomes of staged anterior urethroplasties, and isolate risk factors for recurrence.

Methods
We reviewed urethroplasty database for all patients who underwent staged urethroplasty from 2000 to 2017. Follow-up included a cystoscopy 4 months after their 2nd stage to assess early success, and then annual follow-up thereafter with post-void residual and symptom assessment. Stricture characteristics, etiology and graft type were analyzed with regards to success.

Results
Forty-nine patients were eligible for inclusion. The median stricture length was 7 cm (3–17 cm). The early success rate demonstrated by cystoscopy at 4 months was 100%. Long-term success was 96.4% in buccal graft (BMG) only patients; however, long-term success fell considerably to 53% in patients requiring any use split thickness skin graft (STSG) in the first stage. Median follow up time was 57 months (6–240 months). On analysis, age, increased stricture length and especially the use of STSG all appeared to be associated with late recurrence. The recurrence group had longer stricture length and were more likely to be panurethral. All recurrences occurred after the initial 4-month cystoscopy with a median time to recurrence of 78 months.

Conclusion
Staged repairs that are amenable to BMG-only repairs have high long-term success rates. Increasing stricture length and the addition of split-thickness skin graft were associated with lower success rate in staged urethral reconstruction. Patients requiring staged repairs often experience recurrence in a very delayed fashion reinforcing the need for close, long-term follow up.
Predictors of functional mitral regurgitation recurrence after percutaneous mitral valve repair
Authors: Hellhammer Katharina , Haurand Jean M. , Spieker Maximilian , Luedike Peter , Rassaf Tienush , Zeus Tobias , Kelm Malte , Westenfeld Ralf , Horn Patrick 
Published: April 2021

AbstractWe aimed to identify predictors of mitral regurgitation recurrence (MR) after percutaneous mitral valve repair (PMVR) in patients with functional mitral regurgitation (FMR). Patients with FMR were enrolled who underwent PMVR using the MitraClip® device. Procedural success was defined as reduction of MR of at least one grade to MR grade ≤ 2 + assessed at discharge. Recurrence of MR was defined as MR grade 3 + or worse at one year after initially successful PMVR. A total of 306 patients with FMR underwent PMVR procedure. In 279 out of 306 patients (91.2%), PMVR was successfully performed with MR grade ≤ 2 + at discharge. In 11.4% of these patients, MR recurrence of initial successful PMVR after 1 year was observed. Recurrence of MR was associated with a higher rate of heart failure rehospitalization during the 12 months follow-up (52.0% vs. 30.3%; p = 0.029), and less improvement in New York Heart Association (NYHA) functional class [68% vs. 19% of the patients presenting with NYHA functional class III or IV one year after PMVR when compared to patients without recurrence (p = 0.001)]. Patients with MR recurrence were characterized by a higher left ventricular sphericity index {0.69 [Interquartile range (IQR) 0.64, 0.74] vs. 0.65 (IQR 0.58, 0.70), p = 0.003}, a larger left atrium volume [118 (IQR 96, 143) ml vs. 102 (IQR 84, 123) ml, p = 0.019], a larger tenting height 10 (IQR 9, 13) mm vs. 8 (IQR 7, 11) mm (p = 0.047), and a larger mitral valve annulus [41 (IQR 38, 43) mm vs. 39 (IQR 36, 40) mm, p = 0.015] when compared to patients with durable optimal long-term results. In a multivariate regression model, the left ventricular sphericity index [Odds Ratio (OR) 1.120, 95% Confidence Interval (CI) 1.039–1.413, p = 0.003)], tenting height (OR 1.207, 95% CI 1.031–1.413, p = 0.019), and left atrium enlargement (OR 1.018, 95% CI 1.000–1.038, p = 0.047) were predictors for MR recurrence after 1 year. In patients with FMR, baseline parameters of advanced heart failure such as spherical ventricle, tenting height and a large left atrium might indicate risk of recurrent MR one year after PMVR.
Seasonally changing contribution of sea ice and snow cover to uncertainty in multi-decadal Eurasian surface air temperature trends based on CESM simulations
Authors: Ding Zhaomin , Wu Renguang 
Published: April 2021

AbstractThis study investigates the impact of sea ice and snow changes on surface air temperature (SAT) trends on the multidecadal time scale over the mid- and high-latitudes of Eurasia during boreal autumn, winter and spring based on a 30-member ensemble simulations of the Community Earth System Model (CESM). A dynamical adjustment method is used to remove the internal component of circulation-induced SAT trends. The leading mode of dynamically adjusted SAT trends is featured by same-sign anomalies extending from northern Europe to central Siberia and to the Russian Far East, respectively, during boreal spring and autumn, and confined to western Siberia during winter. The internally generated component of sea ice concentration trends over the Barents-Kara Seas contributes to the differences in the thermodynamic component of internal SAT trends across the ensemble over adjacent northern Siberia during all the three seasons. The sea ice effect is largest in autumn and smallest in winter. Eurasian snow changes contribute to the spread in dynamically adjusted SAT trends as well around the periphery of snow covered region by modulating surface heat flux changes. The snow effect is identified over northeast Europe-western Siberia in autumn, north of the Caspian Sea in winter, and over eastern Europe-northern Siberia in spring. The effects of sea ice and snow on the SAT trends are realized mainly by modulating upward shortwave and longwave radiation fluxes.
Development of a diagnostic model to identify patients at high risk for cerebellopontine angle lesions
Authors: Hentschel Mayke , Rovers Maroeska , Steens Stefan , Hannink Gerjon , Kunst Henricus 
Published: April 2021

Abstract
Purpose
To develop a diagnostic model to identify patients at high risk of a CPA lesion.

Methods
A consecutive cohort of patients with AAD referred by a general practitioner, who underwent their first MRI examination of the CPA between 2005 and 2015 was included. Demographics, symptoms, findings during physical examination, and pure-tone audiometry were used as potential predictors. The presence of a CPA lesion was used as outcome.

Results
We analyzed data of 2,214 patients, detecting 73 CPA lesions in 69 (3.1%) patients. The final model contained eleven variables, namely gender [male] [OR 1.055 (95% CI 0.885–1.905)], sudden onset of hearing loss [OR 0.768 (95% CI 0.318–0.992)], gradual onset of hearing loss [OR 1.069 (95% CI 0.500–1.450)], unilateral tinnitus [OR 0.682 (95% CI 0.374–0.999)], complaints of unilateral aural fullness [OR 1.006 (95% CI 0.783–2.155)], instability [OR 1.006 (95% CI 0.580–2.121)], headache [OR 0.959 (95% CI 0.059–1.090)], facial numbness [OR 2.746 (95% CI 0.548–11.085)], facial nerve dysfunction during physical examination [OR 1.024 (95% CI 0.280–3.702)], and asymmetry in BC at 1 kHz [OR 1.013 (95% CI 1.000–1.027)] and 4 kHz [OR 1.008 (95% CI 1.000–1.026)].

Conclusion
The proposed diagnostic model is a first step in selecting patients with a high risk of a CPA lesion among those with AAD. It needs to be externally validated prior to its implementation in clinical practice.
Daily 30-min exposure to artificial gravity during 60 days of bed rest does not maintain aerobic exercise capacity but mitigates some deteriorations of muscle function: results from the AGBRESA RCT
Authors: Kramer Andreas , Venegas-Carro María , Zange Jochen , Sies Wolfram , Maffiuletti Nicola A. , Gruber Markus , Degens Hans , Moreno-Villanueva María , Mulder Edwin 
Published: April 2021

Abstract
Purpose
Spaceflight impairs physical capacity. Here we assessed the protective effect of artificial gravity (AG) on aerobic exercise capacity and muscle function during bed rest, a spaceflight analogue.

Methods
24 participants (33 ± 9 years, 175 ± 9 cm, 74 ± 10 kg, 8 women) were randomly allocated to one of three groups: continuous AG (cAG), intermittent AG (iAG) or control (CTRL). All participants were subjected to 60 days of six-degree head-down tilt bed rest, and subjects of the intervention groups completed 30 min of centrifugation per day: cAG continuously and iAG for 6 × 5 min, with an acceleration of 1g at the center of mass. Physical capacity was assessed before and after bed rest via maximal voluntary contractions, cycling spiroergometry, and countermovement jumps.

Results
AG had no significant effect on aerobic exercise capacity, flexor muscle function and isometric knee extension strength or rate of force development (RFD). However, AG mitigated the effects of bed rest on jumping power (group * time interaction of the rmANOVA p < 0.001; iAG − 25%, cAG − 26%, CTRL − 33%), plantar flexion strength (group * time p = 0.003; iAG − 35%, cAG − 31%, CTRL − 48%) and plantar flexion RFD (group * time p = 0.020; iAG − 28%, cAG − 12%, CTRL − 40%). Women showed more pronounced losses than men in jumping power (p < 0.001) and knee extension strength (p = 0.010).

Conclusion
The AG protocols were not suitable to maintain aerobic exercise capacity, probably due to the very low cardiorespiratory demand of this intervention. However, they mitigated some losses in muscle function, potentially due to the low-intensity muscle contractions during centrifugation used to avoid presyncope.
Post-exercise cardiac autonomic and cardiovascular responses to heart rate-matched and work rate-matched hypoxic exercise
Authors: Fornasiero Alessandro , Zignoli Andrea , Rakobowchuk Mark , Stella Federico , Savoldelli Aldo , Skafidas Spyros , Schena Federico , Pellegrini Barbara , Mourot Laurent 
Published: April 2021

Abstract
Purpose
This study investigated the effect of performing hypoxic exercise at the same heart rate (HR) or work rate (WR) as normoxic exercise on post-exercise autonomic and cardiovascular responses.

Methods
Thirteen men performed three interval-type exercise sessions (5 × 5-min; 1-min recovery): normoxic exercise at 80% of the WR at the first ventilatory threshold (N), hypoxic exercise (FiO2 = 14.2%) at the same WR as N (H-WR) and hypoxic exercise at the same HR as N (H-HR). Autonomic and cardiovascular assessments were conducted before and after exercise, both at rest and during active squat–stand manoeuvres (SS).

Results
Compared to N, H-WR elicited a higher HR response (≈ 83% vs ≈ 75%HRmax, p < 0.001) and H-HR a reduced exercise WR (− 21.1 ± 9.3%, p < 0.001). Cardiac parasympathetic indices were reduced 15 min after exercise and recovered within 60 min in N and H-HR, but not after H-WR (p < 0.05). H-WR altered cardiac baroreflex sensitivity (cBRS) both at rest and during SS (specifically in the control of blood pressure fall during standing phases) in the first 60 min after the exercise bout (p < 0.05). Post-exercise hypotension (PEH) did not occur in H-HR (p > 0.05) but lasted longer in H-WR than in N (p < 0.05).

Conclusions
Moderate HR-matched hypoxic exercise mimicked post-exercise autonomic responses of normoxic exercise without resulting in significant PEH. This may relate to the reduced WR and the limited associated mechanical/metabolic strain. Conversely, WR-matched hypoxic exercise impacted upon post-exercise autonomic and cardiovascular responses, delaying cardiac autonomic recovery, temporarily decreasing cBRS and evoking prolonged PEH.
Impact of COVID-19 on an established physical activity and behaviour change support programme for cancer survivors: An exploratory survey of the Macmillan Move More service for Northern Ireland
Authors: Brown Malcolm , O’Connor Dominic , Murphy Claire , McClean Maura , McMeekin Alexandra , Prue Gillian 
Published: April 2021

Abstract
Purpose
The recent coronavirus pandemic (COVID-19) has affected the delivery of routine cancer care and supportive services. The Macmillan Move More Northern Ireland (MMNI) programme provides access to physical activity and behavioural change support before, during and after cancer treatment. This evaluation details the impact of the pandemic on the MMNI participants and identifies methods to adapt service delivery.

Methods
A multiple-choice and short answer online survey was sent to 730 MMNI participants, to investigate the impact of the initial, national COVID-19 lockdown. Specifically, the survey examined physical activity patterns, the physical/emotional/social impact of restrictions and attitudes towards digitally supported exercise. Free text responses were analysed thematically with findings verified within the research team.

Results
377 participants completed the survey (52% response rate). 50% of respondents had breast cancer, with 36 other diagnoses registered (82% were female). Participants reported physical activity levels decreased during restrictions, citing isolation; declining health/fitness; lack of access and motivation. The dataset trended towards women and those diagnosed with breast cancer. 71% reported the pandemic impacted their physical (n=119) and/or psychosocial (n=231) wellbeing. Many respondents were availing of digitally supported exercise, whilst half of males did not engage (46%). Finally, 80% of respondents were interested in using a MMNI smart application.

Conclusion
The COVID-19 pandemic has affected participant physical activity levels. Supervised classes were the most popular (pre-pandemic), with enforced leisure centre closures prompting this reduction. The pandemic has negatively affected the psychosocial wellbeing (mental health) of participants, compounded by the restrictions imposed on the traditional delivery of MMNI. This impact is felt equally across cancer types. Participants with breast cancer are the most engaged in using digital technology to access exercise. Although underrepresented, men require greater targeting to ensure equality in access to online services.
Global higher integrability for minimisers of convex functionals with (p,q)-growth
Authors: Koch Lukas 
Published: April 2021

AbstractWe prove global $$W^{1,q}({\varOmega },{\mathbb {R}}^m)$$

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Correlation between serum carnosinase concentration and renal damage in diabetic nephropathy patients
Authors: Zhou Zhou , Liu Xue-qi , Zhang Shi-qi , Qi Xiang-ming , Zhang Qiu , Yard Benito , Wu Yong-gui 
Published: April 2021

AbstractDiabetic nephropathy (DN) is one of the major complications of diabetes and contributes significantly towards end-stage renal disease. Previous studies have identified the gene encoding carnosinase (CN-1) as a predisposing factor for DN. Despite this fact, the relationship of the level of serum CN-1 and the progression of DN remains uninvestigated. Thus, the proposed study focused on clarifying the relationship among serum CN-1, indicators of renal function and tissue injury, and the progression of DN. A total of 14 patients with minimal changes disease (MCD) and 37 patients with DN were enrolled in the study. Additionally, 20 healthy volunteers were recruited as control. Further, DN patients were classified according to urinary albumin excretion rate into two groups: DN with microalbuminuria (n = 11) and DN with macroalbuminuria (n = 26). Clinical indicators including urinary protein components, serum carnosine concentration, serum CN-1 concentration and activity, and renal biopsy tissue injury indexes were included for analyzation. The serum CN-1 concentration and activity were observed to be the highest, but the serum carnosine concentration was the lowest in DN macroalbuminuria group. Moreover, within DN group, the concentration of serum CN-1 was positively correlated with uric acid (UA, r = 0.376, p = 0.026) and serum creatinine (SCr, r = 0.399, p = 0.018) and negatively correlated with serum albumin (Alb, r = − 0.348, p = 0.041) and estimated glomerular filtration rate (eGRF, r = − 0.432, p = 0.010). Furthermore, the concentration of serum CN-1 was discovered to be positively correlated with indicators including 24-h urinary protein–creatinine ratio (24 h-U-PRO/CRE, r = 0.528, p = 0.001), urinary albumin-to-creatinine ratio (Alb/CRE, r = 0.671, p = 0.000), urinary transferrin (TRF, r = 0.658, p = 0.000), retinol-binding protein (RBP, r = 0.523, p = 0.001), N-acetyl-glycosaminidase (NAG, r = 0.381, p = 0.024), immunoglobulin G (IgG, r = 0.522, p = 0.001), cystatin C (Cys-C, r = 0.539, p = 0.001), beta-2-microglobulin (β2-MG, r = 0.437, p = 0.009), and alpha-1-macroglobulin (α1-MG, r = 0.480, p = 0.004). Besides, in DN with macroalbuminuria group, serum CN-1 also showed a positive correlation with indicators of fibrosis, oxidative stress, and renal tubular injury. Taken together, our data suggested that the level of CN-1 was increased as clinical DN progressed. Thus, the level of serum CN-1 might be an important character during the occurrence and progression of DN. Our study will contribute significantly to future studies focused on dissecting the underlying mechanism of DN.
Application of secondary pH measurement method for homogeneity and stability assessment of reference materials
Authors: Koleva Boryana , Dimitrova Lyudmila , Stoica Daniela , Fisicaro Paola 
Published: April 2021

AbstractIn this work, the development and optimization of a secondary method for pH measurement using a differential potentiometric cell are described. The method was optimized and validated by measurement of three certified primary buffer solutions (CRMs) with nominal pH values of 4.005, 6.865 and 9.180 at 25 °C. The method was applied to assess homogeneity and stability of phosphate buffer solution with nominal pH of 7.000 at 25 °C which will be used as test item in proficiency testing schemes for pH measurement of testing laboratories. The experiments carried out and described in this article proved that this particular design of secondary differential potentiometric cell requires small volume of solutions, is fast, accurate and precise and is suitable for the characterization of secondary buffer solutions and assessment of homogeneity and stability of buffer solutions.
The assessment of virtual reality training in antromastoidectomy simulation
Authors: Mickiewicz Patrycja , Gawęcki Wojciech , Gawłowska Maria Bratumiła , Talar Marcin , Węgrzyniak Magdalena , Wierzbicka Małgorzata 
Published: April 2021

AbstractVirtual reality (VR) may be a good alternative for cadaveric temporal bone surgical dissection courses, which are an important part of otolaryngology resident’s training. The aim of the study was to assess the VR temporal bone surgery simulator in an antromastoidectomy simulation. The VR system was based on the Geomagic Touch Haptic Device from 3D System. The research was designed as a prospective study, with three sessions of VR simulation training. The group of four ENT specialists unexperienced in otosurgery and 11 otorhinolaryngology residents performed a series of virtual dissections of a VR temporal bone model. Two experts with a broad experience in ear surgery participated in the study as supervisors for all the participants. At the end of each session, the experts controlled the accuracy of the simulated surgery performance assigning positive points for each correctly performed step and negative points for each mistake. After each session, participants of the study were asked to fill in the questionnaire concerning their impression of a VR system simulation. The evaluation of every simulation (total score) was based on the duration of a VR session, the quality of performance (positive points) and the number of mistakes (negative points). During consecutive VR sessions, evident shortening of the length of performance, as well as an improvement in the quality of performance and reduction in mistakes, was observed. Sixty percent of study participants answered that signaling damage to the critical elements was good (40%—sufficient), and 67% assessed that they had made a progress in consecutive sessions. After three sessions, 100% of participants indicated higher self-confidence in relation to their own surgical skills. Also, all the participants indicated that VR training should be included in a routine educational program for medical students. VR training provides a structured, safe and supportive environment to familiarize oneself with complex anatomy and practical skills.
Comparing ontologies and databases: a critical review of lifecycle engineering models in manufacturing
Authors: Ramis Ferrer Borja , Mohammed Wael M. , Ahmad Mussawar , Iarovyi Sergii , Zhang Jiayi , Harrison Robert , Martinez Lastra Jose Luis 
Published: April 2021

AbstractThe literature on the modeling and management of data generated through the lifecycle of a manufacturing system is split into two main paradigms: product lifecycle management (PLM) and product, process, resource (PPR) modeling. These paradigms are complementary, and the latter could be considered a more neutral version of the former. There are two main technologies associated with these paradigms: ontologies and databases. Database technology is widespread in industry and is well established. Ontologies remain largely a plaything of the academic community which, despite numerous projects and publications, have seen limited implementations in industrial manufacturing applications. The main objective of this paper is to provide a comparison between ontologies and databases, offering both qualitative and quantitative analyses in the context of PLM and PPR. To achieve this, the article presents (1) a literature review within the context of manufacturing systems that use databases and ontologies, identifying their respective strengths and weaknesses, and (2) an implementation in a real industrial scenario that demonstrates how different modeling approaches can be used for the same purpose. This experiment is used to enable discussion and comparative analysis of both modeling strategies.
The use of ketogenic diets in cancer patients: a systematic review
Authors: Römer Maximilian , Dörfler Jennifer , Huebner Jutta 
Published: April 2021

AbstractKetogenic diets are a widely known, yet controversial treatment for cancer patients. In this review, we summarize the clinical evidence for anti-tumor effects, as well as the effects on anthropometry, quality of life, adverse events and adherence in cancer patients. In April 2019, a systematic search was conducted searching five electronic databases (EMBASE, Cochrane, PsychInfo, CINAHL and Medline) to find studies analyzing the use, effectiveness and potential harm of a ketogenic diet in cancer patients of any age as sole or complementary therapy. From all 19.211 search results, 46 publications concerning 39 studies with 770 patients were included in this systematic review. The therapy concepts included all forms of diets with reduced carbohydrate intake, that aimed to achieve ketosis for patients with different types of cancer. Most studies had a low quality, high risk of bias and were highly heterogeneous. There was no conclusive evidence for anti-tumor effects or improved OS. The majority of patients had significant weight loss and mild to moderate side effects. Adherence to the diet was rather low in most studies. Due to the very heterogeneous results and methodological limitations of the included studies, clinical evidence for the effectiveness of ketogenic diets in cancer patients is still lacking.