bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enabling factors for adopting sustainable, organic wine production
Authors: Cobelli Nicola , Chiarini Andrea , Giaretta Elena 
Published: February 2021

PurposeThis study expands the debate on the reasons that wine producers adopt sustainable, organic wine production. It aims to ascertain the enabling factors facilitating behavioral intention regarding such an adoption and whether these factors can be combined in a conceptual, measurable model.Design/methodology/approachA sample of 157 Italian winery companies was used. Results were analyzed through the unified theory of acceptance and use of technology model, various quantitative methods and a multi-regression model.FindingsGender, age, role, experience in the sector and company existence do not affect behavioral intention. Conversely, performance expectancy, effort expectancy, social influences, facilitating conditions, attitude and self-efficacy strongly affect behavioral intention, whereas the determinant anxiety has a negative effect. Further, four factors account for most of the variability in behavioral intention.Research limitations/implicationsThe research is limited to Italian wine producers, and the discussion is based on quantitative results alone. Qualitative data would probably produce a richer, more comprehensive understanding of some phenomena.Practical implicationsManagers and entrepreneurs intending to invest in organic wine production can gain a detailed understanding of factors that affect the behavioral intention toward these technologies by comparing their attitudes with those of Italian producers.Originality/valueSeveral studies have focused on wine consumers' behavior, but very few have investigated wineries' intention to adopt organic wine technology and the likely driving factors.
The effect of clam shell powder on kinetics of water absorption of jute epoxy composite
Authors: Jena Hemalata , Panigrahi Abinash 
Published: February 2021

Purpose
Here, attempts have been made to explore the possible use of Marine waste as filler materials into the bio-fibre composites. Clam shell is a type of marine waste which belongs to the class of Bivalvia. It is mainly made of aragonite crystalline polymorphs. This paper aims to develop a new class of natural fibre composite in which jute fibre as reinforcement, epoxy as matrix and clam shell, as particulate microsphere filler. The study investigates the effects of different amounts of clam shell powder on the kinetics of water absorption of jute fibre-reinforced epoxy composite. Two different environmental conditions at room temperature, i.e. distilled water and seawater, are collected for this purpose. Moisture absorption reduces when clam shell is added to the jute-epoxy composite. The curve of water absorption of jute-epoxy composites with filler loading at both environmental conditions follows as Fickian behaviour.

Design/methodology/approach
Hand lay-up technique to fabricate the composite – Experimental observation

Findings
The incorporation of Clam shell filler in jute epoxy composite modified the water absorption property of the composite. Hence the present marine waste is an potential filler in jute fibre reinforced polymer composite.

Originality/value
The paper demonstrates a new class hybrid composite material which uses a marine waste as important phase in the bio-fibre-reinforced composite. It is a new work submitted for original research paper.
Empagliflozin alleviates ethanol‐induced cardiomyocyte injury through inhibition of mitochondrial apoptosis via a SIRT1/PTEN/Akt pathway
Authors: Tian Ge , Yu Yang , Deng Hanyu , Yang Liu , Shi Xiaojing , Yu Bo 
Published: February 2021

AbstractEthanol‐induced myocardial injury involves multiple pathophysiological processes including apoptosis. Empagliflozin (EMPA), is a novel hypoglycaemic drug which possesses multiple pharmacologically relevant protective effects, including anti‐apoptotic, anti‐inflammatory and antioxidant effects. However, whether EMPA treatment has a protective effect on ethanol‐induced myocardial injury has not been assessed, to the best of our knowledge. Therefore, the aim of this study was to determine the effect of EMPA treatment on ethanol‐induced myocardial injury and the underlying mechanism. An ethanol‐induced myocardial injury model was established by culturing H9c2 cells treated with 200 mmol/L ethanol for 24 hours, and additional groups of ethanol treated cells were also treated with EMPA with or without SIRT1 inhibitors prior to ethanol treatment. Cell viability and apoptosis were assessed using a CCK‐8 assay and flow cytometry, respectively. The expression of apoptosis‐related proteins was assessed using western blotting. The results showed that EMPA pretreatment resulted in increased cell viability and a decrease in LDH activity. Moreover, EMPA pretreatment significantly reduced apoptosis of cardiomyocytes, and reduced the expression of cleaved caspase 3. Furthermore, EMPA increased the expression of SIRT1, increased the phosphorylation levels of Akt, and reduced the expression of PTEN. EMPA also reduced ethanol‐induced mitochondrial apoptosis, increasing the Bcl‐2/Bax ratio and the mitochondrial membrane potential. However, the cardioprotective effects of EMPA were abrogated when cells were pretreated with a SIRT1 inhibitor. In conclusion, EMPA can alleviate ethanol‐induced myocardial injury by inhibiting mitochondrial apoptosis via the SIRT1/PTEN/Akt pathway. Therefore, EMPA may be a novel target for treatment of ethanol‐induced myocardial injury.
WALK THE PIPELINE: Urban Infrastructure Landscapes in Bengaluru's Long Twentieth Century
Authors: Castán Broto Vanesa , Sudhira H.S. , Unnikrishnan Hita 
Published: February 2021

AbstractWalking reveals how urban infrastructure lends identity to the urban landscape. This article focuses on the oldest water pipeline in the city of Bengaluru, India. A series of vignettes trace the linear trajectory of the walk both in terms of the spatial orientation of the pipeline, and its trajectory through time. Through space, the pipeline connects the centre of the city with its suburbs, tracking differential and sometimes invisible patterns of urbanization that follow the city's sprawl. Through time, the pipeline connects water narratives, from nostalgic notions of precolonial management to the contemporary construction of scarcity. The use of walking as a methodological tool draws attention to the subsumed and often invisible experiences of inequity in various parts of the city. The pipeline is a maker of urban stories alongside routine practices and larger strategic projects of urban development. While the pipeline enables the provision of water, the neighbourhoods it passes through are sometimes excluded from the service it provides. Strategic projects have attempted to control water resources following different ways of imagining the city. Still, such urban imaginations coexist with a more extensive set of everyday practices that engage with the pipeline in the urban landscape.
Malvaviscus yellow mosaic virus, a divergent begomovirus carrying a nanovirus‐like nonanucleotide and a modified stem‐loop structure
Authors: Lima Alison T. M. , Orílio Anelise F. , Almeida Mariana M. S. , Rocha Carolina S. , Barros Danielle R. , Castillo‐Urquiza Gloria P. , Silva Fábio N. , Xavier César A. D. , Bruckner Fernanda P. , Alfenas‐Zerbini Poliane , Barbosa Julio C. , Albuquerque Leonardo C. , Inoue‐Nagata Alice K. , Kitajima Elliot W. , Zerbini Francisco Murilo 
Published: February 2021

AbstractBegomoviruses (family Geminiviridae) have a circular, ssDNA genome encapsidated in twinned icosahedral particles. Numerous begomoviruses infecting noncultivated malvaceous plants have been described, and evidence suggests that they may have given rise to some of the viruses currently found in crop plants. Here we describe an atypical begomovirus infecting ornamental Turk's hat plants (Malvaviscus arboreus, Malvaceae). Total DNA was extracted, and the viral genome was amplified by rolling‐circle amplification (RCA), cloned and sequenced. Sequence and phylogenetic analyses indicated that the virus corresponds to a new begomovirus phylogenetically related to other malvaceous‐infecting begomoviruses from Brazil, and for which the name malvaviscus yellow mosaic virus (MvYMV) is proposed. M. arboreus plants inoculated with MvYMV infectious clones showed bright yellow mosaic and the virus progeny was identical to the isolate inoculated, thus fulfilling Koch's postulates. Strikingly, MvYMV has a nanovirus/alphasatellite‐like nonanucleotide sequence (5′‐TAGTATTAC‐3′). Moreover, a short sequence located 5′ of the nonanucleotide potentially forms a minor hairpin structure embedded in the major hairpin. Intramolecular interactions involving the sequence of the atypical hairpin structure were predicted and functional analyses were conducted to assess its biological relevance, revealing that the MvYMV Rep protein recognises this unique replication origin but not the typical begomovirus origin. Thus, MvYMV is a begomovirus with an atypical origin of replication and naturally found in noncultivated malvaceous plants.
Solubility of bioceramic‐ and epoxy resin‐based root canal sealers: A systematic review and meta‐analysis
Authors: Silva Emmanuel J. N. L. , Cardoso Milla Lessa , Rodrigues Jéssica Perrut , De‐Deus Gustavo , Fidalgo Tatiana Kelly da Silva 
Published: February 2021

AbstractThis systematic review and meta‐analysis evaluated whether epoxy resin‐based root canal sealers present an increased solubility than calcium silicate‐based root canal sealers. A systematic search was performed in the following databases: PubMed, Science Direct, Scopus, Web of Science and Open Grey. The inclusion criteria consisted of in vitro studies that compared the solubility of epoxy resin‐based and calcium silicate‐based sealers. The quality assessment and data extraction of the selected articles were performed. The meta‐analysis of the pooled data and the subgroups according to the root thirds were carried out using the RevMan software (P < 0.05). After the duplicate removal and eligibility criteria assessment, a total of 22 studies were included all of them were considered as having a low risk of bias. The meta‐analysis demonstrated overall lower solubility of AH Plus. AH Plus presented lower solubility than Bio‐C Sealer, BioRoot RCS, MTA Fillapex, Sealer Plus and Total Fill BC Sealer.
Increased risk of herpes zoster in patients with psoriasis: A longitudinal follow‐up study using a national sample cohort
Authors: Min Chanyang , Yoo Dae Myoung , Kim Miyoung , Choi Hyo Geun 
Published: February 2021

AbstractBackground/objectiveAlthough previous studies reported the relationship between psoriasis and herpes zoster, the number of study is not sufficient to support the conclusions. The purpose of this study was to evaluate the association between psoriasis and herpes zoster.MethodsThe data of a nationally representative Korean cohort collected in the Korean Health Insurance Review and Assessment (HIRA) System from 2002 to 2013 were used. Psoriasis was defined ≥ 2 International Classification of Diseases 10th revision (ICD‐10) L40 codes. Among them, severe psoriasis was defined as psoriatic medication use, including acitretin, systemic corticosteroid, cyclosporine and methotrexate. Other psoriasis was defined as mild psoriasis. Herpes zoster was defined as ≥ 2 ICD‐10 B02 codes or ≥ 1 B02 code with antiviral medication use. Psoriasis patients (n = 11 009) and control participants (n = 44 036) were matched 1:4 by age, sex, income and region of residence. A stratified Cox proportional hazard model was used stratified by age, sex, income and region of residence. Crude and adjusted hazard ratios (HRs) were calculated for the risk of herpes zoster in the total psoriasis group, mild psoriasis group, and severe psoriasis group and compared with those in each matched control group.ResultsThe HR for herpes zoster was higher in the psoriasis group than in control group (adjusted HR = 1.22, 95% CI = 1.12–1.33, P < 0.001). The findings were consistent between the mild psoriasis and severe psoriasis patients and their matched controls, and between male psoriasis patients in all age groups and their matched male controls.ConclusionsPsoriasis may increase the risk of herpes zoster, especially in males.
A patient‐centric pathway for testicular cancer – A multicentre study investigating the uptake of semen cryopreservation and impact on treatment
Authors: Scott Charles , Omar Kawa , Alnajjar Hussain M. , Alifrangis Constantine , Ahmed Kamran , Muneer Asif 
Published: February 2021

AbstractBackgroundThe option of semen cryopreservation following a diagnosis of testicular cancer shows a variable uptake with the option to cryopreserve before surgery often dependent on the preference of the treating clinician and the fertility laboratory resources available.ObjectivesTo assess whether the introduction of a patient‐centric pathway for managing suspected testicular cancer increases the uptake of semen cryopreservation and the impact of this on surgical waiting times.Materials and methodsA multicentre retrospective analysis of patients treated as part of a patient‐centric pathway was conducted for suspected testicular cancer at two specialist centres within a one‐stop testicular clinic. Clinical information, including semen cryopreservation acceptance rate, time intervals to surgery and CT scan, TNM stage, histology and age, was recorded from an institutional database.ResultsEighty nine patients (median age: 34 years (range: 14–89)) underwent orchidectomy for suspected testicular cancer over a 15‐month period after the introduction of a patient‐centric testicular cancer pathway at two UK centres. The overall uptake of semen cryopreservation was 68.5% (n = 61) with all men under the age of 33 years accepting this option. A microdissection oncoTESE was performed in 9/61 (14.8%) patients who attempted cryopreservation but were found to be azoospermic. Pre‐operative CT imaging was completed for 85.4% of patients, and the median time from initial outpatient consultation to orchidectomy was 9 days.Discussion and conclusionsA patient‐centric pathway ensures that the uptake of semen cryopreservation remains high particularly for those men within the common age for paternity. It also identifies men who may benefit from microdissection oncoTESE for complex cases such as tumours in solitary testicles, bilateral tumours or an atrophic contralateral testicle as well as those diagnosed with de novo azoospermia. The additional time taken for semen cryopreservation to be performed did not significantly delay orchidectomy or influence the decisions for adjuvant treatment.
Association of peripartum management and high maternal blood loss at cesarean delivery for placenta accreta spectrum (PAS): A multinational database study
Authors: Schwickert Alexander , van Beekhuizen Heleen J. , Bertholdt Charline , Fox Karin A. , Kayem Gilles , Morel Olivier , Rijken Marcus J. , Stefanovic Vedran , Strindfors Gita , Weichert Alexander , Weizsaecker Katharina , Braun Thorsten ,   the International Society for Placenta Accreta Spectrum (IS‐PAS)
Published: February 2021

AbstractIntroductionPlacenta accreta spectrum (PAS) carries a high burden of adverse maternal outcomes, especially significant blood loss, which can be life‐threatening. Different management strategies have been proposed but the association of clinical risk factors and surgical management options during cesarean delivery with high blood loss is not clear.Material and methodsIn this international multicenter study, 338 women with PAS undergoing cesarean delivery were included. Fourteen European and one non‐European center (USA) provided cases treated retrospectively between 2008 and 2014 and prospectively from 2014 to 2019. Peripartum blood loss was estimated visually and/or by weighing and measuring of volume. Participants were grouped based on blood loss above or below the 75th percentile (>3500 ml) and the 90th percentile (>5500 ml).ResultsPlacenta percreta was found in 58% of cases. Median blood loss was 2000 ml (range: 150‐20 000 ml). Unplanned hysterectomy was associated with an increased risk of blood loss >3500 ml when compared with planned hysterectomy (adjusted OR [aOR] 3.7 [1.5‐9.4], p = 0.01). Focal resection was associated with blood loss comparable to that of planned hysterectomy (crude OR 0.7 [0.2–2.1], p = 0.49). Blood loss >3500 ml was less common in patients undergoing successful conservative management (placenta left in situ, aOR 0.1 [0.0–0.6], p = 0.02) but was more common in patients who required delayed hysterectomy (aOR 6.5 [1.7–24.4], p = 0.001). Arterial occlusion methods (uterine or iliac artery ligation, embolization or intravascular balloons), application of uterotonic medication or tranexamic acid showed no significant effect on blood loss >3500 ml. Patients delivered by surgeons without experience in PAS were more likely to experience blood loss >3500 ml (aOR 3.0 [1.4–6.4], p = 0.01).ConclusionsIn pregnant women with PAS, the likelihood of blood loss >3500 ml was reduced in planned vs unplanned cesarean delivery, and when the surgery was performed by a specialist experienced in the management of PAS. This reinforces the necessity of delivery by an expert team. Conservative management was also associated with less blood loss, but only if successful. Therefore, careful patient selection is of great importance. Our study showed no consistent benefit of other adjunct measures such as arterial occlusion techniques, uterotonics or tranexamic acid.
A pharmacotherapy self‐assessment improves prescribing by prompting junior doctors to study further
Authors: van der Steen Carlijn N.W. , Brokx Steffi , van den Hanenberg Floor , van der Stelt Rianda , van Onzenoort‐Bokken Lonneke , Keijsers Carolina J.P.W. 
Published: February 2021

AimsJunior doctors frequently prescribe incorrectly and this can cause serious harm to patients. Pharmacotherapy education in most medical schools falls short in preparing their students to prescribe safely in clinical practice. According to the theory of assessment‐driven learning, a pharmacotherapy self‐assessment for junior doctors may reduce potential harmful prescriptions in clinical practice, by revealing deficits in prescribing knowledge and skills.MethodsIn this single centre, prospective cohort study, the potential harmful prescriptions of junior doctors in clinical practice were compared before and after a pharmacotherapy self‐assessment with and without additional pharmacotherapy education.ResultsPotential harmful prescriptions best known to cause harm to patients were studied in all the prescriptions written out by 199 junior doctors in the first 2 months of their employment in our hospital. The pharmacotherapy self‐assessment reduced the total number of potential harmful prescriptions made by junior doctors relative to those made by junior doctors in the control group (1.3 vs. 3.2%, respectively; P < .001). Additional education did not reduce potential harmful prescriptions beyond the effect of the self‐assessment alone (1.3 vs. 1.0%, P > .05).ConclusionsPharmacotherapy self‐assessment leads to fewer potential harmful prescriptions made by junior doctors in clinical practice, thereby improving patient safety. More research is needed to investigate whether additional pharmacotherapy education strategies reduce potential harmful prescriptions further.
TBL1XR1 associated intellectual disability, a new missense variant with dysmorphic features plus autism: Expanding the phenotypic spectrum
Authors: Arroyo Carrera Ignacio , Fernández‐Burriel Miguel , Lapunzina Pablo , Tenorio Jair Antonio , García Navas Verónica Deyanira , Márquez Isidro Elena 
Published: February 2021

AbstractMissense and frameshift pathogenic variants and microdeletions involving TBL1XR1 gene have been described in patients with intellectual disability, autism, Rett‐like features and schizophrenia, some of them with the clinical diagnosis of Pierpont syndrome, a rare pattern of multiple congenital anomalies, but others without dysmorphic findings or with non‐specific ones, and also patients with only some of the features associated with Pierpont syndrome. We here present a case with a de novo novel missense variant in TBL1XR1 gene with overlapping features with Pierpont syndrome and autism, a neurobehavioral manifestation not previously reported in Pierpont syndrome. This patient expands the phenotypic spectrum of TBL1XR1 gene pathogenic variants.
The Haitian orphanage crisis: Exporting neoliberal family ideals in the debate on vulnerable childhoods in Haiti
Authors: Hoffman Diane M. 
Published: February 2021

AbstractIn light of recent global debates over the dangers of institutionalised orphan care, a new model of family care premised on the trope of family reunification has emerged among Haitian and US faith‐based actors as the best alternative for ensuring vulnerable children's well‐being. This article offers a critical cultural reading of narratives on family reunification in Haiti in social media and advocacy discourse, revealing how this approach privileges Northern assumptions about proper parenting and family life. Not only are these ideas a mismatch with realities in Haiti, they evoke deficit constructions of family and childhood that facilitate the nation's further positioning as a subject of transnational neoliberal governmentality.
Green bridges in a re‐colonizing landscape: Wolves (Canis lupus) in Brandenburg, Germany
Authors: Plaschke Mike , Bhardwaj Manisha , König Hannes J. , Wenz Elena , Dobiáš Kornelia , Ford Adam T. 
Published: February 2021

AbstractGray wolves (Canis lupus) are recolonizing many parts of central Europe and are a key part of international conservation directives. However, roads may hinder the reestablishment of gray wolves throughout their historic range by reducing landscape connectivity and increasing mortality from wildlife‐vehicle collisions. The impact of roads on wolves might be mitigated by the construction of green bridges (i.e., large vegetated overpasses, designed to accommodate the movement of wildlife over transportation corridors). In this study, we investigated the seasonal and diurnal use of a green bridge by wolves and three of their main prey species: red deer (Cervus elaphus), roe deer (Capreolus capreolus), and wild boar (Sus scrofa). We found that all four species used the green bridge. Wolves were most active in winter, whereas prey species were most active in spring and summer. All species were more active at dusk and during the night than at dawn and during the day. We found no evidence that wolf presence influenced bridge‐use by prey species, consistent with other tests of the prey‐trap hypothesis. Our results suggest that green bridges are used by wolves and prey species alike, and may foster connectivity and recolonization for these species in rewilding landscapes.