bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Load, Angle, and Contraction Type on Clinically Assessed Knee Joint Position Sense
Authors: Haggerty Adam L. , Simon Janet E. , Grooms Dustin R. , Russell Jeffrey A. 
Published: August 2021

Context: Proprioception is an individual’s awareness of body position in 3-dimensional space. How proprioceptive acuity changes under varying conditions such as joint position, load, and concentric or eccentric contraction type is not well understood. In addition, a limitation of the variety of techniques to assess proprioception is the lack of clinically feasible methods to capture proprioceptive acuity. The purpose of this study was to implement a readily available instrument, a smartphone, in the clinical evaluation of knee active joint position sense and to determine how joint angle, joint loading, and quadriceps contraction type affect an individual’s active joint position sense. Design: Cross-over study. Methods: Twenty healthy, physically active university participants (10 women and 10 men: 21.4 [2.0] y; 1.73 [0.1] m; 70.9 [14.3] kg) were recruited. Individuals were included if they had no neurological disorder, no prior knee surgery, and no recent knee injury. The participants were given a verbal instruction to locate a target angle and then were tasked with reproducing the target angle without visual or verbal cues. An accelerometer application on a smartphone was used to assess the angle to the nearest tenth of a degree. Three variables, each with 2 levels, were analyzed in this study: load (weighted and unweighted), contraction type (eccentric and concentric), and joint position (20° and 70°). A repeated-measures analysis of variance was conducted to assess the within-subjects factors of load, contraction, and position. Results: A significant difference of 0.50° (0.19°) of greater error with eccentric versus concentric contraction (P = .02) type was identified. In addition, a significant interaction was found for contraction × position, with a mean increase in error of 0.98° (0.33°) at the 20° position when contracting eccentrically (P = .03). Conclusions: Contraction type, specifically eccentric contraction at 20°, showed significantly greater error than concentric contraction. This suggests that, during eccentric contractions of the quadriceps, there may be decreased proprioceptive sensitivity compared with concentric contractions.
Biallelic GINS2 variant p.(Arg114Leu) causes Meier-Gorlin syndrome with craniosynostosis
Authors: Nabais Sá Maria J , Miller Kerry A , McQuaid Mary , Koelling Nils , Wilkie Andrew O M , Wurtele Hugo , de Brouwer Arjan P M , Oliveira Jorge 
Published: August 2021

IntroductionReplication of the nuclear genome is an essential step for cell division. Pathogenic variants in genes coding for highly conserved components of the DNA replication machinery cause Meier-Gorlin syndrome (MGORS).ObjectiveIdentification of novel genes associated with MGORS.MethodsExome sequencing was performed to investigate the genotype of an individual presenting with prenatal and postnatal growth restriction, a craniofacial gestalt of MGORS and coronal craniosynostosis. The analysis of the candidate variants employed bioinformatic tools, in silico structural protein analysis and modelling in budding yeast.ResultsA novel homozygous missense variant NM_016095.2:c.341G>T, p.(Arg114Leu), in GINS2 was identified. Both non-consanguineous healthy parents carried this variant. Bioinformatic analysis supports its classification as pathogenic. Functional analyses using yeast showed that this variant increases sensitivity to nicotinamide, a compound that interferes with DNA replication processes. The phylogenetically highly conserved residue p.Arg114 localises at the docking site of CDC45 and MCM5 at GINS2. Moreover, the missense change possibly disrupts the effective interaction between the GINS complex and CDC45, which is necessary for the CMG helicase complex (Cdc45/MCM2–7/GINS) to accurately operate. Interestingly, our patient’s phenotype is strikingly similar to the phenotype of patients with CDC45-related MGORS, particularly those with craniosynostosis, mild short stature and patellar hypoplasia.ConclusionGINS2 is a new disease-associated gene, expanding the genetic aetiology of MGORS.
Mass correction and deformation of slowly rotating anisotropic neutron stars based on Hartle–Thorne formalism
Authors: Pattersons M. L. , Sulaksono A. 
Published: August 2021

AbstractDue to their compactness, neutron stars are the best study matter in high density and strong-field gravity. Hartle and Thorne have proposed a good approximation or perturbation procedure within general relativity for slowly rotating relativistic stars by assuming the matter inside the stars is an ideal isotropic fluid. This study extends the analytical Hartle–Thorne formalism for slowly rotating neutron stars, including the possibility that the neutron star pressure can be anisotropic. We study the impact of neutron stars’ anisotropy pressure on mass correction and deformation numerically. For the anisotropic model, we use the Bowers-Liang model. For the equation of state of neutron stars, we use a relativistic mean-field BSP parameter set with the hyperons, and for the crust equation of state, we use the one of Miyatsu et al. We have found that the mass of neutron stars increases but the radius decreases by increasing $$\lambda _{BL}$$

λ

BL

value. Therefore, the NS compactness increases when $$\lambda _{BL}$$

λ

BL

becomes larger. This fact leads to a condition in which NS is getting harder to deformed when the $$\lambda _{BL}$$

λ

BL

increased.
Dynamics and epicyclic motions of particles around the Schwarzschild–de Sitter black hole in perfect fluid dark matter
Authors: Rayimbaev Javlon , Shaymatov Sanjar , Jamil Mubasher 
Published: August 2021

AbstractIn this paper, we investigate circular orbits for test particles around the Schwarzschild–de Sitter (dS) black hole surrounded by perfect fluid dark matter. We determine the region of circular orbits bounded by innermost and outermost stable circular orbits. We show that the impact of the perfect fluid dark matter shrinks the region where circular orbits can exist as the values of both innermost and outermost stable circular orbits decrease. We find that for specific lower and upper values of the dark matter parameter there exist double matching values for inner and outermost stable circular orbits. It turns out that the gravitational attraction due to the dark matter contribution dominates over cosmological repulsion. This gives rise to a remarkable result in the Schwarzschild–de Sitter black hole surrounded by dark matter field in contrast to the Schwarzschild–de Sitter metric. Finally, we study epicyclic motion and its frequencies with their applications to twin peak quasi-periodic oscillations (QPOs) for various models. We find the corresponding values of the black hole parameters which could best fit and explain the observed twin peak QPO object GRS 1915+109 from microquasars.
The structural, magnetic and electrical transport properties of perovskite La0.67Sr0.33Mn1−x(VMn)xO3: The B-sites vacancies as a rapier
Authors: Ji Denghui , Zhang Bin , Yang Yong , Wang Shuling , Liu Yingdi , Shi Yuanping , Feng Shunzhen , Zhao Cuijian , Shi Shaohui , Zhang Qingqing 
Published: August 2021

The polycrystalline samples of manganites perovskite [Formula: see text] with B-sites vacancies were synthesized using the conventional solid-state reaction method. The results based on the X-Ray Diffraction (XRD) and Scanning Electron Microscope (SEM) analyses show that the samples with [Formula: see text] have a secondary phase of lanthanum oxides. It indicates there is a maximum vacancy content at the B-sites with [Formula: see text]. By X-ray Photoelectron Spectra (XPS), the ionicities of oxygen were determined to be 0.762, 0.842, and 0.886, corresponding to [Formula: see text], 0.03, and 0.05, respectively. The B-sites vacancy plays an important role in magnetic performances: (i) B-sites vacancy changes the contents and the average cant angle of Mn cations, and makes the specific saturation magnetization at 100 K and 300 K increase, and then decrease rapidly. (ii) The Curie temperature changes in a small range from 363.93 K to 366.00 K, resulting from both the double exchange interaction increasing and the double exchange path destroyed by the vacancies. (iii) The magnetoresistance (MR) at room temperature achieves 6.97% in the [Formula: see text] sample, whose value is larger than that of [Formula: see text] sample.
De Rossellini a Rossellini: dois processos de criação que se sobrepõem
Authors: Roque Isabel Rebelo 
Published: August 2021

O cineasta italiano Roberto Rossellini foi, de todos os cineastas neorrealistas, quem levou ao cinema de ficção a estética documental em sua maior radicalidade. Em sua “trilogia da guerra”, constituída por Roma, cidade aberta, Paisà e Alemanha, ano zero, essa estética documental deriva em grande medida do uso de atores não profissionais, recrutados entre a população local, e da filmagem em locação. Na trilogia e em vários de seus filmes, anteriores e posteriores, seu irmão mais novo, o compositor Renzo Rossellini, assina as trilhas sonoras. No presente artigo, discutiremos os processos de criação e as escolhas estéticas de um e de outro, de modo a evidenciar o quanto, frequentemente, parecem chocar-se ou no mínimo sobrepor-se. Tomando por objeto o trabalho desenvolvido por ambos em Alemanha, ano zero, apresentaremos como ponto fulcral um gráfico – por nós elaborado – em que relacionaremos cinquenta e cinco sequências fílmicas à respectiva banda sonora, como meio de demonstrar nossa tese.
Advanced Placement and Initial College Enrollment: Evidence from an Experiment
Authors: Conger Dylan , Long Mark C. , McGhee, Jr. Raymond 
Published: August 2021

AbstractTo evaluate how Advanced Placement (AP) courses affect college-going, we randomly assigned the offer of enrollment into an AP science course to over 1,800 students in twenty-three schools that had not previously offered the course. We find no AP course effects on students’ college entrance exam scores (SAT/ACT). As expected, AP course-takers are substantially more likely to take the AP exam than their control group counterparts. At the same time, treatment group students opt out of the exam at very high rates and most do not earn a passing score on the AP exam. Though less precisely estimated, the results also suggest that taking the AP course increases students’ aspirations to attend higher-quality colleges but does not lead to enrollment in such institutions.
The opioid epidemic from the acute care hospital front line
Authors: Macintyre Pamela E 
Published: August 2021

Prescription opioid use has risen steeply for over two decades, driven primarily by advocacy for better management of chronic non-cancer pain, but also by poor opioid stewardship in the management of acute pain. Inappropriate prescribing, among other things, contributed to the opioid ‘epidemic’ and striking increases in patient harm. It has also seen a greater proportion of opioid-tolerant patients presenting to acute care hospitals. Effective and safe management of acute pain in opioid-tolerant patients can be challenging, with higher risks of opioid-induced ventilatory impairment and persistent post-discharge opioid use compared with opioid-naive patients. There are also increased risks of some less well known adverse postoperative outcomes including infection, earlier revision rates after major joint arthroplasty and spinal fusion, longer hospital stays, higher re-admission rates and increased healthcare costs. Increasingly, opioid-free/opioid-sparing techniques have been advocated as ways to reduce patient harm. However, good evidence for these remains lacking and opioids will continue to play an important role in the management of acute pain in many patients. Better opioid stewardship with consideration of preoperative opioid weaning in some patients, assessment of patient function rather than relying on pain scores alone to assess adequacy of analgesia, prescription of immediate release opioids only and evidence-based use of analgesic adjuvants are important. Post-discharge opioid prescribing should be contingent on an assessment of patient risk, with short-term only use of opioids. In partnership with pharmacists, nursing staff, other medical specialists, general practitioners and patients, anaesthetists remain ideally positioned to be involved in opioid stewardship in the acute care setting.
Odontogenic Keratocyst: A Clinical Entity With Favorable Response to Active Decompression and Distraction Sugosteogenesis
Authors: Porte Juan-Pablo , Guerrero Lidia M. , Rivera Bonifacio , Wiscovitch Andres , Castro-Núñez Jaime 
Published: August 2021

Objective: The purpose of this study was to determine the usefulness of active decompression and distraction sugosteogenesis (ADDS) for the management of non-syndromic odontogenic keratocysts (OKC). Materials and Methods: A retrospective case series study was designed and implemented. The study observed the Declaration of Helsinki on medical protocol and ethics and it was approved by the university’s Institutional Review Board (IRB). The medical files of all patients who underwent ADDS for OKCs of the jaws at the Department of Oral and Maxillofacial Surgery of a tertiary university-affiliated medical center were reviewed. Data were collected on patient’s age, gender, presenting signs and symptoms, lesion location, locularity, pre-ADDS, size of the lesion, post-ADDS, pain, days with bloody discharge and/or proteinaceous fluid inside the system’s external unit, days to achieve hermetic seal, size of the lesion 2 weeks after ADDS, percentage of reduction, patient’s complaints/complications, and follow-up period. Pre- and post-ADDS panoramic radiographs were reviewed for reduction parameters. Results: Six patients, 5 males and 1 female, with an average age of 45.16 years (range 16-74 years) were studied. ADDS was performed during 4 weeks in all patients. During the therapy, the extraoral unit collected blood during 2.83 days in average. In average, after the third day, the cystic cavity started to drain a proteinaceous fluid for about 9.33 days (range 6-15 days). The average pre-ADDS Standard Lesional Area Index (SLAI) was 18.17 cm2 (range 4.40 cm2-34.58 m2) and, after 2 weeks of ADDS, the average SLAI was 5.47 cm2 (range 0.49 cm2-15.39 cm2). The average percentage of reduction, after 2 weeks, was 73.93% (range 55.49%-97.51%), which yielded an overall good reaction of OKCs to ADDS. No significant reduction of the lesions was observed from week 2 to week 4, when ADDS ceased. All lesions were enucleated after 3 months. After an average of 14 months of follow-up (12 to 17 months), no signs of recurrence have been observed.
Preemptive Utilization of Anterior Belly of the Digastric Muscle Flaps in Transoral Robotic Radical Tonsillectomy
Authors: Daigle Olivia , Gardner James Reed , King Deanne , Moreno Mauricio Alejandro , Sunde Jumin , Vural Emre 
Published: August 2021

ObjectiveTo demonstrate the use of an anterior belly of the digastric muscle flap (ABDMF) during transoral robotic radical tonsillectomy (TORRT) with concomitant neck dissection with the intent of preventing the formation of postoperative pharyngocutaneous fistulas.Study DesignRetrospective study.SettingSingle academic tertiary care center.MethodsIn this study, all patients were included who underwent TORRT plus limited pharyngectomy with concomitant neck dissection and ABDMF for the treatment of oropharyngeal squamous cell carcinoma between September 2012 and September 2020. The rate of fistula formation was assessed in patients with preemptive utilization of ABDMF.ResultsA total of 43 patients underwent TORRT with neck dissection and ABDMF. No patients developed a fistula in the postoperative period or associated morbidity with the use of this flap.ConclusionPreemptive use of ABDMF in TORRT with concomitant neck dissection represents a reconstructive option that may help prevent the formation of pharyngocutaneous fistula by reinforcing the posteroinferior boundary of the parapharyngeal space.
Prevalence and molecular characterization of group B streptococcus in pregnant women from hospitals in Ohangwena and Oshikoto regions of Namibia
Authors: Haimbodi Erastus Lafimana , Mukesi Munyaradzi , Moyo Sylvester Rodgers 
Published: August 2021

Abstract
Background
The main purpose of this study was to investigate the prevalence rate, antimicrobial susceptibility patterns and molecular characteristics of Streptococcus agalactiae isolated from pregnant women at 35 weeks of gestation and above, who attended antenatal screening at selected hospitals in Ohangwena and Oshikoto regions of Namibia.

Results
Out of 210 women screened for Group B Streptococcus (GBS), 12 (5.7%) were colonised of which 25.0% were colonised rectovaginally, 58.0% vaginally and 17.0% rectally. No significant association was reported between GBS colonisation and maternal age, geographic location, marital status, education, employment, parity, still births and miscarriages (P values > 0.05). Antimicrobial susceptibility was reported at 100% for ampicillin, penicillin & ceftriaxone which are commonly used for empiric treatment of infection with GBS. Resistance to tetracycline was reported at 100%. Tetracycline resistance gene tet(M) was present in 88.9% of the isolates only and none of the isolates presented with tet(O). Polysaccharide capsular type Ia was found in 9(50%) and Ib was found in 1(5.5%) of the total isolates. The remaining isolates were not typeable using PCR.

Conclusion
Streptococcus agalactiae’s positive rate was 5.7% among the pregnant women examined. Socio-demographic and obstetric factors had no influence on GBS colonisation (P values > 0.05). No resistance was reported to ampicillin, penicillin and ceftriaxone. No sensitivity was reported to tetracycline. Fifty percent of the isolates were capsular type Ia, 5.5% were type Ib and 44.4% were not typeable using PCR. The study provides crucial information for informing policy in screening of GBS in pregnant women.
RRM1 and ERCC1 as biomarkers in patients with locally advanced and metastatic malignant pleural mesothelioma treated with continuous infusion of low-dose gemcitabine plus cisplatin
Authors: Muñoz-Montaño Wendy , Muñiz-Hernández Sae , Avilés-Salas Alejandro , Catalán Rodrigo , Lara-Mejía Luis , Samtani-Bassarmal Suraj , Cardona Andres F. , Mendoza-Desión Jorge , Hernández-Cueto Daniel , Maldonado Altagracia , Baay-Guzmán Guillermina , Huerta-Yepes Sara , Arrieta Oscar 
Published: August 2021

Abstract
Background
Malignant Pleural Mesothelioma (MPM) is a rare but aggressive neoplasia that usually presents at advanced stages. Even though some advances have been achieved in the management of patients with MPM, this malignancy continuous to impose a deleterious prognosis for affected patients (12–18 months as median survival, and 5–10% 5-year survival rate), accordingly, the recognition of biomarkers that allow us to select the most appropriate therapy are necessary.

Methods
Immunohistochemistry semi-quantitative analysis was performed to evaluate four different biomarkers (ERCC1, RRM1, RRM2, and hENT-1) with the intent to explore if any of them was useful to predict response to treatment with continuous infusion gemcitabine plus cisplatin. Tissue biopsies from patients with locally advanced or metastatic MPM were analyzed to quantitatively asses the aforementioned biomarkers. Every included patient received treatment with low-dose gemcitabine (250 mg/m2) in a 6-h continuous infusion plus cisplatin 35 mg/m2 on days 1 and 8 every 3 weeks as first-line therapy.

Results
From the 70 eligible patients, the mean and standard deviation (SD) for ERCC1, RRM1, RRM2 and hENT-1 were 286,178.3 (± 219, 019.8); 104,647.1 (± 65, 773.4); 4536.5 (± 5, 521.3); and 2458.7 (± 4, 983.4), respectively. Patients with high expression of RRM1 had an increased median PFS compared with those with lower expression (9.5 vs 4.8 months, p = < 0.001). Furthermore, high expression of RRM1 and ERCC1 were associated with an increased median OS compared with their lower expression counterparts; [(23.1 vs 7.2 months for RRM1 p = < 0.001) and (17.4 vs 9.8 months for ERCC1 p = 0.018)].

Conclusions
ERCC1 and RRM1 are useful biomarkers that predict better survival outcomes in patients with advanced MPM treated with continuous infusion of gemcitabine plus cisplatin.
Mild knee osteoarthritis predicts dissatisfaction after total knee arthroplasty: a prospective study of 186 patients aged 65 years or less with 2-year follow-up
Authors: Leppänen Sanni , Niemeläinen Mika , Huhtala Heini , Eskelinen Antti 
Published: August 2021

Abstract
Background and aims
The incidence of total knee arthroplasty (TKA) is increasing, especially among younger working-age patients. However, dissatisfaction rates in this population are higher than among older patients. The aim of this study was to assess the rates of dissatisfaction and persistent pain after TKA and to evaluate those factors that predict these outcomes.

Material and methods
In total, 186 patients undergoing unilateral TKA aged 65 years or less were enrolled into this prospective observational study with 2-year follow-up. To assess the outcome, the visual analogue scales regarding satisfaction and persistent pain at rest and during exercise were used. In addition, the association between patients´ demographics, radiographic severity of knee osteoarthritis (OA), patient-reported outcome measures (PROMs) and dissatisfaction and persistent pain were tested by univariate logistic regression analysis. Mild OA was defined as Kellgren-Lawrence (KL) grade 2 and severe OA as KL grade 3–4. Furthermore, multiple logistic regression analysis was also conducted to test statistically significant relations.

Results
After 2 years, 12 % (n = 23) of patients were dissatisfied with the outcome of TKA, 27 % (n = 50) reported persistent pain during exercise and 10 % (n = 18) at rest. Patients with mild knee OA were significantly more dissatisfied (28.6 %) than patients with more severe OA (8.7 %) (p = 0.003). Younger patients had an increased risk for both dissatisfaction and persistent pain. Apart from KOOS Quality of Life, poor preoperative KOOS subscores were also predictive for these outcomes.

Conclusion
Mild radiographic knee OA was the main predicting factor for dissatisfaction after TKA. Thus, performing TKA for such patients should be carefully considered. Furthermore, these patients should be informed about the increased risk for dissatisfaction and the same seems to apply to younger patients. Interestingly, when TKA is performed for patients with more severe knee OA, the satisfaction rates seem to be somewhat higher than those previously reported.

Trial registration
The study was retrospectively registered with ClinicalTrials.gov (registration number NCT03233620) on 28 July 2017.