bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic/genomic testing: defining the parameters for ethical, legal and social implications (ELSI)
Authors: Ascencio-Carbajal Tania , Saruwatari-Zavala Garbiñe , Navarro-Garcia Fernando , Frixione Eugenio 
Published: November 2021

Abstract
Background
Genetic/genomic testing (GGT) are useful tools for improving health and preventing diseases. Still, since GGT deals with sensitive personal information that could significantly impact a patient’s life or that of their family, it becomes imperative to consider Ethical, Legal and Social Implications (ELSI). Thus, ELSI studies aim to identify and address concerns raised by genomic research that could affect individuals, their family, and society. However, there are quantitative and qualitative discrepancies in the literature to describe the elements that provide content to the ELSI studies and such problems may result in patient misinformation and harmful choices.

Methods
We analyzed the major international documents published by international organizations to specify the parameters that define ELSI and the recognized criteria for GGT, which may prove useful for researchers, health professionals and policymakers. First, we defined the parameters of the ethical, legal and social fields in GGT to avoid ambiguities when using the acronym ELSI. Then, we selected nine documents from 44 relevant publications by international organizations related to genomic medicine.

Results
We identified 29 ELSI sub-criteria concerning to GGT, which were organized and grouped within 10 minimum criteria: two from the ethical field, four from the legal field and four from the social field. An additional analysis of the number of appearances of these 29 sub-criteria in the analyzed documents allowed us to order them and to determine 7 priority criteria for starting to evaluate and propose national regulations for GGT.

Conclusions
We propose that the ELSI criteria identified herein could serve as a starting point to formulate national regulation on personalized genomic medicine, ensuring consistency with international bioethical requirements.
A genetic researcher’s devil’s dilemma: Warn relatives about their genetic risk or respect confidentiality agreements with research participants?
Authors: van den Heuvel Lieke M. , Maeckelberghe Els L. M. , Ploem M. Corrette , Christiaans Imke 
Published: November 2021

Abstract
Background
With advances in sequencing technologies, increasing numbers of people are being informed about a genetic disease identified in their family. In current practice, probands (the first person in a family in whom a genetic predisposition is identified) are asked to inform at-risk relatives about the diagnosis. However, previous research has shown that relatives are sometimes not informed due to barriers such as family conflicts. Research on family communication in genetic diseases aims to explore the difficulties encountered in informing relatives and to identify ways to support probands in this.

Main body
Research on family communication may also reveal that participants did not inform their relatives about the risk of a serious genetic condition, even when preventive and treatment options are available. Researchers may then face a dilemma: Do they need to warn at-risk relatives about the finding? Or do they keep silent due to prior confidentiality agreements with study participants?

Conclusions
We believe that the absolute confidence promised to research participants outweighs the interests of their relatives, even though it can be claimed that relatives at risk of a genetic disease do, in principle, have a right to know information collected about their health. Not respecting confidentiality agreements could cause distrust between researchers and research participants and possibly harm the relationship between probands and relatives. Relatives' health interests can still be taken into account without jeopardizing participant trust, by considering alternative scenarios, including sharing general study findings on the barriers participants experience with their healthcare professionals and by offering participants psychosocial support for family communication.
Current practices of peripheral intravenous catheter fixation in pediatric patients and factors influencing pediatric nurses’ knowledge, attitude and practice concerning peripheral intravenous catheter fixation: a cross-sectional study
Authors: Huang Li-Sha , Huang Yan , Hu Juan 
Published: November 2021

Abstract
Background
Peripheral intravenous catheters (PIVCs) are the most widely used intravenous treatment tools for hospitalized patients. Compared to adult patients, PIVC fixation issues are more likely to occur in pediatric patients and can be more complex. However, research on PIVC fixation in pediatric patients is rare. This study aimed to investigate the pass rate for PIVC fixation in pediatric patients and the factors that influence pediatric nurses’ knowledge, attitude, and practice (KAP) concerning PIVC fixation.

Methods
An on-site investigation using a self-designed PIVC fixation standard inspection checklist for first insertion and routine maintenance in pediatric patients and a follow-up questionnaire survey investigating pediatric nurses’ KAP concerning PIVC fixation was conducted in a hospital in China between November 1 and December 31, 2019. Data were analyzed using SPSS 21.0.

Results
The pass rate for PIVC fixation in pediatric patients was 52.02%. The pediatric nurses’ knowledge, attitude and practice scores on PIVC fixation were 7.2 ± 1.36, 28.03 ± 2.42, and 31.73 ± 2.94, respectively. The multivariate linear regression analysis results show that department (where nurses are working in) and job position are the factors that influence knowledge score (B > 0, P < 0.05); department is also a factor that influences attitude score (B > 0, P < 0.05); and department and nursing hierarchy are the factors that influence practice score (B > 0, P < 0.05).

Conclusion
PIVC fixation in pediatric patients is affected by multiple factors. The level of pediatric nurses’ KAP on PIVC fixation needs to be improved. It is suggested that guidelines for PIVC fixation in pediatric patients be formulated and that training on PIVC fixation in pediatric patients be provided for pediatric nurses in an effort to raise the pass rate in terms of PIVC fixation in pediatric patients.
Antibody conversion rates to SARS-CoV-2 in saliva from children attending summer schools in Barcelona, Spain
Authors: Dobaño Carlota , Alonso Selena , Fernández de Sevilla Mariona , Vidal Marta , Jiménez Alfons , Pons Tomas Gemma , Jairoce Chenjerai , Melé Casas María , Rubio Rocío , Hernández García María , Ruiz-Olalla Gemma , Girona-Alarcón Mònica , Barrios Diana , Santano Rebeca , Mitchell Robert A. , Puyol Laura , Mayer Leonie , Chi Jordi , Rodrigo Melero Natalia , Carolis Carlo , Garcia-Miquel Aleix , Bonet-Carne Elisenda , Claverol Joana , Cubells Marta , Fortuny Claudia , Fumadó Victoria , Jou Cristina , Muñoz-Almagro Carmen , Izquierdo Luis , Bassat Quique , Gratacós Eduard , Aguilar Ruth , García-García Juan José , Moncunill Gemma , Jordan Iolanda 
Published: November 2021

Abstract
Background
Surveillance tools to estimate viral transmission dynamics in young populations are essential to guide recommendations for school opening and management during viral epidemics. Ideally, sensitive techniques are required to detect low viral load exposures among asymptomatic children. We aimed to estimate SARS-CoV-2 infection rates in children and adult populations in a school-like environment during the initial COVID-19 pandemic waves using an antibody-based field-deployable and non-invasive approach.

Methods
Saliva antibody conversion defined as ≥ 4-fold increase in IgM, IgA, and/or IgG levels to five SARS-CoV-2 antigens including spike and nucleocapsid constructs was evaluated in 1509 children and 396 adults by high-throughput Luminex assays in samples collected weekly in 22 summer schools and 2 pre-schools in 27 venues in Barcelona, Spain, from June 29th to July 31st, 2020.

Results
Saliva antibody conversion between two visits over a 5-week period was 3.22% (49/1518) or 2.36% if accounting for potentially cross-reactive antibodies, six times higher than the cumulative infection rate (0.53%) assessed by weekly saliva RT-PCR screening. IgG conversion was higher in adults (2.94%, 11/374) than children (1.31%, 15/1144) (p=0.035), IgG and IgA levels moderately increased with age, and antibodies were higher in females. Most antibody converters increased both IgG and IgA antibodies but some augmented either IgG or IgA, with a faster decay over time for IgA than IgG. Nucleocapsid rather than spike was the main antigen target. Anti-spike antibodies were significantly higher in individuals not reporting symptoms than symptomatic individuals, suggesting a protective role against COVID-19.

Conclusion
Saliva antibody profiling including three isotypes and multiplexing antigens is a useful and user-friendlier tool for screening pediatric populations to detect low viral load exposures among children, particularly while they are not vaccinated and vulnerable to highly contagious variants, and to recommend public health policies during pandemics.
dEchorate: a calibrated room impulse response dataset for echo-aware signal processing
Authors: Carlo Diego Di , Tandeitnik Pinchas , Foy Cedrić , Bertin Nancy , Deleforge Antoine , Gannot Sharon 
Published: November 2021

AbstractThis paper presents a new dataset of measured multichannel room impulse responses (RIRs) named dEchorate. It includes annotations of early echo timings and 3D positions of microphones, real sources, and image sources under different wall configurations in a cuboid room. These data provide a tool for benchmarking recent methods in echo-aware speech enhancement, room geometry estimation, RIR estimation, acoustic echo retrieval, microphone calibration, echo labeling, and reflector position estimation. The dataset is provided with software utilities to easily access, manipulate, and visualize the data as well as baseline methods for echo-related tasks.
Peroxiredoxin-6 regulates p38-mediated epithelial–mesenchymal transition in HCT116 colon cancer cells
Authors: Chae Unbin , Kim Bokyung , Kim HanSeop , Park Young-Ho , Lee Seung Hwan , Kim Sun-Uk , Lee Dong-Seok 
Published: November 2021

AbstractBackgroundPeroxiredoxins (Prxs) are antioxidant enzymes that protect cells from oxidative stress induced by several factors. They regulate several signaling pathways, such as metabolism, immune response, and intracellular reactive oxygen species (ROS) homeostasis. Epithelial–mesenchymal transition (EMT) is a transforming process that induces the loss of epithelial features of cancer cells and the gain of the mesenchymal phenotype. The EMT promotes metastasis and cancer cell progression mediated by several pathways, such as mitogen-activated protein kinases (MAPKs) and epigenetic regulators.MethodsWe used Prx6 overexpressed and downregulated HCT116 cells to study the mechanism between Prx6 and colon cancer. The expression of Prx6, GAPDH, Snail, Twist1, E-cadherin, Vimentin, N-cadherin, ERK, p-ERK, p38, p-p38, JNK, and p-JNK were detected by Western blotting. Additionally, an animal study for xenograft assay was conducted to explore the function of Prx6 on tumorigenesis. Cell proliferation and migration were determined by IncuCyte Cell Proliferation and colony formation assays.ResultsWe confirmed that the expression of Prx6 and EMT signaling highly occurs in HCT116 compared with that in other colon cancer cell lines. Prx6 regulates the EMT signaling pathway by modulating EMT-related transcriptional repressors and mesenchymal genes in HCT116 colon cancer cells. Under the Prx6-overexpressed condition, HCT116 cells proliferation increased significantly. Moreover, the HCT116 cells proliferation decreased in the siPrx6-treated cells. Eleven days after HCT116 cell injection, Prx6 was overexpressed in the HCT116-injected mice, and the tumor volume increased significantly compared with that of the control mice. Furthermore, Prx6 regulates EMT signaling through p38 phosphorylation in colon cancer cells.ConclusionWe suggested that Prx6 regulates EMT signaling pathway through p38 phosphorylation modulation in HCT116 colon cancer cells.
Differentiation syndrome-induced Myopericarditis in the induction therapy of acute Promyelocytic leukemia: a case report
Authors: Shenoy Shabari Mangalore , Di Vitantonio Thomas , Plitt Anna , Perez-Johnston Rocio , Gutierrez Jillian , Knorr David A. , Stein Eytan M. , Liu Jennifer E. , Feldman Stephanie 
Published: November 2021

Abstract
Background
All trans retinoic acid (ATRA) has revolutionized the treatment and outcomes of patients with Acute Promyelocytic Leukemia (APL). Induction therapy with ATRA is associated with the rare but potentially fatal complication of differentiation syndrome. While the presentation of this syndrome is varied, myopericarditis as a manifestation of differentiation syndrome is often fatal and rarely reported in literature. We present a case of myopericarditis as the sole manifestation of differentiation syndrome in a patient on induction therapy with ATRA and arsenic trioxide for APL.

Clinical presentation
A 62 year old woman with remote history of breast and uterine cancer presented to the hospital for expedited work up of easy bruising and expanding hematomas. She was diagnosed with APL with peripheral blood and bone marrow cytogenetics revealing t (15;17) translocation and initiated on induction therapy with ATRA and ATO as well as steroids for differentiation syndrome prophylaxis. Eighteen days into induction therapy, patient developed pleuritic chest pain, elevated cardiac biomarkers, ECG changes suggestive of pericarditis. Cardiac magnetic resonance imaging showed patchy multifocal sub-epicardial late gadolinium enhancement and elevated T2 signal consistent with acute myopericarditis. Given the timing of symptom onset and lack of other identifiable cause, patient was diagnosed with differentiation syndrome- induced myopericarditis and promptly initiated on high dose steroids with rapid improvement in symptoms, ECG, and cardiac biomarkers. Patient successfully resumed dose-reduced ATRA and arsenic trioxide without complication.

Conclusion
Myopericarditis can be the sole manifestation of differentiation syndrome and the presentation may be atypical owing to the use of prophylactic steroids as illustrated in our patient’s case. A high index of suspicion for differentiation syndrome, multimodality imaging, and prompt input from multidisciplinary providers is crucial for making the timely diagnosis and initiating life-saving treatment.
Relationships of affective temperament ratings to diagnosis and morbidity measures in major affective disorders
Authors: Miola Alessandro , Baldessarini Ross J. , Pinna Marco , Tondo Leonardo 
Published: November 2021

Abstract

Background
Ratings of affective temperament types show promise in helping to differentiate diagnostic groups among major affective disorders as well as to predict associations with important aspects of morbidity including suicidal risk.

Methods
The Temperament Evaluation of Memphis, Pisa, Paris, and San Diego auto-rating (TEMPS-A) questionnaire was completed by 858 unselected, consecutive, consenting adults diagnosed with a DSM-5 major affective disorder (173 bipolar-1 [BD-1]), 250 BD-2, 435 major depressive disorder [MDD]) to score for anxious (anx), cyclothymic (cyc), dysthymic (dys), hyperthymic (hyp), and irritable (irr) affective temperaments. We tested their associations with diagnosis and selected clinical factors, including diagnosis, depression scores, suicidal ideation or acts, substance abuse, episodes/year, and %-time ill.

Results
Scores for cyc ranked: BD-2 > BD-1 > MDD; anx ranked: MDD > BD-2 > BD-1; irr was greater in BD than MDD; dys was greater in MDD than BD; hyp did not differ by diagnosis. We confirmed associations of suicidal risk with higher scores of all temperament types except lower hyp scores. Higher cyc and irr scores and lower anx scores were associated with substance abuse. Several scores were higher with measures of greater affective morbidity: cyc with current depression, episodes/year, and %-time ill; irr with more episodes and depressions/year and greater %-time manic. Some of these associations were selective for BD or MDD.

Conclusions
The findings indicate that TEMPS-A ratings of affective temperament types can contribute to differential diagnoses and predict types and amounts of affective morbidity, as well as detecting suicidal risks.
Learning Markov Models Via Low-Rank Optimization
Authors: Zhu Ziwei , Li Xudong , Wang Mengdi , Zhang Anru 
Published: November 2021

Taming high-dimensional Markov models In “Learning Markov models via low-rank optimization”, Z. Zhu, X. Li, M. Wang, and A. Zhang focus on learning a high-dimensional Markov model with low-dimensional latent structure from a single trajectory of states. To overcome the curse of high dimensions, the authors propose to equip the standard MLE (maximum-likelihood estimation) with either nuclear norm regularization or rank constraint. They show that both approaches can estimate the full transition matrix accurately using a trajectory of length that is merely proportional to the number of states. To solve the rank-constrained MLE, which is a nonconvex problem, the authors develop a new DC (difference) programming algorithm. Finally, they apply the proposed methods to analyze taxi trips on the Manhattan island and partition the island based on the destination preference of customers; this partition can help balance supply and demand of taxi service and optimize the allocation of traffic resources.
Hereditary haemorrhagic telangiectasia: an overview from an ear, nose and throat perspective
Authors: Green Richard J , Swift Andrew C 
Published: November 2021

Patients with hereditary haemorrhagic telangiectasia can present with a multitude of symptoms caused by telangiectasia and arteriovenous malformations in the nose, brain, gastrointestinal tract, liver and spinal cord. Clinicians should be aware of the potential diagnosis of hereditary haemorrhagic telangiectasia and how to manage these patients both in the acute and chronic setting. Identifying these patients and optimising their management can help reverse the reduced life expectancy back to that of the normal population.The management of these patients is complex and often requires a multidisciplinary approach, with difficult discussions to be had around screening for arteriovenous malformations and genetic testing. The stepwise management ladder can be used in both the medical and surgical strategies; there are multiple pharmacological and surgical options available, all with their own side effects and risks.Patient education is key to help informed decision making. This article outlines the clinical characteristics of the disease and management options available.
Disease-modifying therapies and symptomatic management for primary biliary cholangitis
Authors: Patel Roshni , Portone Greta , Lambert Joshua A , Mak Sau , Alrubaiy Laith 
Published: November 2021

Primary biliary cholangitis is a chronic condition characterised by autoimmune destruction of intralobular bile ducts. Publications have shown widespread gaps in the care of patients with primary biliary cholangitis. This article reviews the literature regarding currently licensed first- and second-line therapies and evaluates therapeutic options for symptomatic management of primary biliary cholangitis. Ursodeoxycholic acid is recommended for all patients with primary biliary cholangitis, with obeticholic acid available as second-line therapy, both having demonstrated safety and efficacy. Potential disease-modifying therapies, such as fibrates and budesonide, require further investigation before licensing. Cholestyramine is first-line therapy for pruritus, albeit with limited evidence and common side-effects. There is no licensed therapy for primary biliary cholangitis-related fatigue; treating underlying causes where applicable is recommended. Disease-modifying and symptomatic therapies must be considered in tandem when managing patients with primary biliary cholangitis. Emerging therapies show initial promise but further randomised trials with long-term follow up are required to evaluate their efficacy as single or combination therapies.
Fan-beam projection for modulation classification in optical wireless communication systems
Authors: Mortada Bidaa , El-Shafai Walid , Nasr Mohamed Safie El-Din , Zahran O. , M. El-Rabaie El-Sayed , Abd El-Samie Fathi E. 
Published: November 2021

The focus of most research nowadays in the field of communication technology is on increasing bandwidth in wireless connectivity. Adaptive modulation can be used to enhance efficiency of communication systems. Adaptive modulation requires modulation format identification (MFI) at the receiver side to avoid the overhead required to determine the modulation type at the receiver. We present an MFI algorithm based on fan-beam projection to generate patterns from the constellation diagrams that are more discriminative. The constellation diagrams are obtained as images for eight different modulation formats (2/4/8/16 - PSK and 8/16/32/64 - QAM). Different classifiers such as AlexNet, VGG16, and VGG19 are studied and compared for the task of MFI. Evaluation of this proposed algorithm is performed by estimating the classification accuracy at different optical signal-to-noise ratios (OSNRs) ranging from 5 to 30 dB. The simulation results reveal that the proposed algorithm succeeds in identifying the wireless optical modulation format blindly with a classification accuracy up to 100% even at low OSNR values less than 8 dB compared with the related work.
Optical fiber temperature sensor based on the upconversion fluorescence intensity ratio of NaYF4:Er3+ excited by a 1525-nm laser
Authors: Huang Yantang , Peng Senlin , Liu Jinping , Feng Zhuohong , Huang Wenqi , Liao Tingdi 
Published: November 2021

Remote and accurate temperature measurements in severe environments are of great importance. A 1525-nm wavelength located in the C band of optical fiber communication is used as a pumping light source for

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