bluuebunny/crossref_metadata_2025_split huggingface dataset:
Near Complete Repair After Myocardial Infarction in Adult Mice by Altering the Inflammatory Response With Intramyocardial Injection of α-Gal Nanoparticles
Authors: Galili Uri , Zhu Zhongkai , Chen Jiwang , Goldufsky Josef W. , Schaer Gary L. 
Published: August 2021

Background: Neonatal mice, but not older mice, can regenerate their hearts after myocardial-infarction (MI), a process mediated by pro-reparative macrophages. α-Gal nanoparticles applied to skin wounds in adult-mice bind the anti-Gal antibody, activate the complement cascade and generate complement chemotactic peptides that recruit pro-reparative macrophages which are further activated by these nanoparticles. The recruited macrophages decrease wound healing time by ~50%, restore the normal skin structure and prevent fibrosis and scar formation in mice.Objectives: The objective of this study is to determine if α-gal nanoparticles injected into the reperfused myocardium after MI in adult-mice can induce myocardial repair that restores normal structure, similar to that observed in skin injuries.Methods and Results: MI was induced by occluding the mid-portion of the left anterior descending (LAD) coronary artery for 30 min. Immediately following reperfusion, each mouse received two 10 μl injections of 100 μg α-gal nanoparticles in saline into the LAD territory (n = 20), or saline for controls (n = 10). Myocardial infarct size was measured by planimetry following Trichrome staining and macrophage recruitment by hematoxylin-eosin staining. Left ventricular (LV) function was measured by echocardiography. Control mice displayed peak macrophage infiltration at 4-days, whereas treated mice had a delayed peak macrophage infiltration at 7-days. At 28-days, control mice demonstrated large transmural infarcts with extensive scar formation and poor contractile function. In contrast, mice treated with α-gal nanoparticles demonstrated after 28-days a marked reduction in infarct size (~10-fold smaller), restoration of normal myocardium structure and contractile function.Conclusions: Intramyocardial injection of α-gal nanoparticles post-MI in anti-Gal producing adult-mice results in near complete repair of the infarcted territory, with restoration of normal LV structure and contractile function. The mechanism responsible for this benefit likely involves alteration of the usual inflammatory response post-MI, as previously observed with regeneration of injured hearts in adult zebrafish, salamanders and neonatal mice.
Investigation on the Application of Taylor Impact Test to High-G Loading
Authors: Juncheng Li , Gang Chen , Yonggang Lu , Fenglei Huang 
Published: August 2021

Taylor impact test is characterized by high impact energy, low cost, and good repeatability, giving it the technical foundation and development potential for application in high-g loading. In this paper, the feasibility of performing high-g load impact testing to a missile-borne recorder by conducting Taylor impact test was studied by combining simulation analyses with experimental verification. Acccording to the actual dimensions of the missile-borne recorder, an experimental piece was designed based on the Taylor impact principle. The impact loading characteristics of the missile-borne recorder were then simulated and analyzed at different impact velocities. In addition, the peak acceleration function and the pulse duration function of the load were fitted to guide the experimental design. A Taylor-Hopkinson impact experiment was also conducted to measure the impact load that was actually experienced by the missile-borne recorder and the results were compared with the results of strain measurements on the Hopkinson incident bar. The results showed that the peak value of impact load, the pulse duration and the waveform of the actual experimental results were in good agreement with the results predicted by the simulations. Additionally, the strain data measured on the incident bar could be used to verify or replace the acceleration testing of the specimen to simplify the experimental process required. Based on the impact velocity, high-g loading impact was achieved with peak values in the 7,000–30,000 g range and durations of 1.3–1 ms, and the waveform generated was a sawtooth wave. The research results provide a new approach for high amplitude and long pulse duration impact loading to large-mass components, and broaden the application field of Taylor impact test.
The Diagnosis of Protein Energy Wasting in Chronic Peritoneal Dialysis Patients Is Influenced by the Method of Calculating Muscle Mass. A Prospective, Multicenter Study
Authors: Roth-Stefanski Cristina Techy , Rodrigues de Almeida Naiane , Biagini Gilson , Scatone Natália K. , Nerbass Fabiana B. , de Moraes Thyago Proença 
Published: August 2021

Objective: To analyze the concordance and agreement between bioimpedance spectroscopy (BIS) and anthropometry for the diagnosis of protein energy wasting (PEW) in chronic peritoneal dialysis patients.Methods: Prospective, multi-center, observational study using multifrequency bioimpedance device (Body Composition Monitor -BCM®- Fresenius Medical Care) and anthropometry for the diagnosis of PEW as recommended by the International Society of Renal Nutrition and Metabolism (ISRNM). Cohen's kappa was the main test used to analyze concordance and a Bland-Altmann curve was built to evaluate the agreement between both methods.Results: We included 137 patients from three PD clinics. The mean age of the study population was 57.7 ± 14.9, 47.8% had diabetes, and 52.2% were male. We calculated the scores for PEW diagnosis at 3 and 6 months after the first collection (T3 and T6) and on average 40% of the study population were diagnosed with PEW. The concordance in the diagnosis of PEW was only moderate between anthropometry and BIS at both T3 and T6. The main factor responsible for our results was a low to moderate correlation for muscle mass in kilograms, with an r-squared (R2) of 0.35. The agreement was poor, with a difference of more than 10 kg of muscle mass on average and with more than a quarter of all cases beyond the limits of agreements.Conclusion: Current diagnosis of PEW may differ depending on the tools used to measure muscle mass in peritoneal dialysis patients.
Population Pharmacokinetics of Polymyxin B and Dosage Optimization in Renal Transplant Patients
Authors: Li Ying , Deng Yang , Zhu Zhen-Yu , Liu Yi-Ping , Xu Ping , Li Xin , Xie Yue-Liang , Yao Heng-Chang , Yang Liu , Zhang Bi-Kui , Zhou Yan-Gang 
Published: August 2021

Currently, polymyxin B has been widely used in the treatment of multidrug-resistant Gram-negative pathogen infections. Due to the limited pharmacokinetic/pharmacodynamic data, the optimal dosage regimen for the recently proposed therapeutic target of the area under the concentration-time curve over 24 h in steady state divided by the minimum inhibitory concentration 50–100 mg⋅h/L has not yet been established. Moreover, most studies have focused on critically ill patients, yet there have been no studies in the field of renal transplantation. To optimize the dosage strategy and reduce the risk of toxicity, a population pharmacokinetics model of polymyxin B with the Phoenix NLME program was developed in our study. A total of 151 plasma samples from 50 patients were collected in the present study. Polymyxin B plasma concentrations were measured by high-performance liquid chromatography-tandem mass spectrometry. A one-compartment model adequately described the data, and the clearance and volume of distribution were 1.18 L/h and 12.09 L, respectively. A larger creatinine clearance was associated with increased clearance of polymyxin B (p &lt; 0.01). Monte Carlo simulation showed that a regimen of a 75 mg loading dose with a 50 mg maintenance dose was a better option to achieve an optimal therapeutic effect (minimum inhibitory concentration ≤1 mg/L) and to reduce the incidence of side effects for patients with renal impairments. The developed model suggested that dosing adjustment should be based on renal function in renal transplant patients.
Correlation of Kinematics and Kinetics of Changing Sagittal Plane Body Position during Landing and the Risk of Non-Contact Anterior Cruciate Ligament Injury
Authors: Kamari Mahgolzahra , Rakwal Randeep , Yoshida Takuya , Tanigawa Satoru , Kuki Seita 
Published: August 2021

Anterior cruciate ligament (ACL) injury is one of the most common knee injuries that negatively affect athletes’ future performance and return to play. The purpose of this study was to examine the correlation of kinematics and kinetics of changing sagittal plane body position during landing and the risk of non-contact ACL injury. Seven university female (age 19.57 ± 0.79 y, height 164.21 ± 8.11 m, weight 60.43 ± 5.99 kg) athletes playing soccer and handball, and with ≥ two years of training volunteered for this research. Three trunk positions: Lean Forward Landing (LFL), Self-selected Landing (SSL), and Upright Landing (URL)—via double/single-leg landing—were captured by a high-speed VICON motion capture system. A 3 × 2 two-way within-subjects ANOVA and Multiple Bonferroni corrected pairwise were used to test for condition (LFL, SSL, URL) and task (single/double-leg) effects (p≤ 0.05). The findings indicated that landing with a deeper knee flexion angle (LFL) would lead to smaller impact forces when compared to upright landing.
CO2 Hydrogenation on NixMg1−xAl2O4: A Comparative Study of MgAl2O4 and NiAl2O4
Authors: Seo Boseok , Ko Eun Hee , Boo Jinho , Kim Minkyu , Kang Dohyung , Park No-Kuk 
Published: August 2021

Due to the increasing attention focused on global warming, many studies on reducing CO2 emissions and developing sustainable energy strategies have recently been performed. One of the approaches is CO2 methanation, transforming CO2 into methane. Such transformation (CO2 + 4H2 → CH4 + 2H2O) provides advantages of carbon liquification, storage, etc. In this study, we investigated CO2 methanation on nickel–magnesium–alumina catalysts both experimentally and computationally. We synthesized the catalysts using a precipitation method, and performed X-ray diffraction, temperature-programmed reduction, and N2 adsorption–desorption tests to characterize their physical and chemical properties. NiAl2O4 and MgAl2O4 phases were clearly observed in the catalysts. In addition, we conducted CO2 hydrogenation experiments by varying with temperatures to understand the reaction. Our results showed that CO2 conversion increases with Ni concentration and that MgAl2O4 exhibits high selectivity for CO. Density functional theory calculations explained the origin of this selectivity. Simulations predicted that adsorbed CO on MgAl2O4(100) weakly binds to the surface and prefers to desorb from the surface than undergoing further hydrogenation. Electronic structure analysis showed that the absence of a d orbital in MgAl2O4(100) is responsible for the weak binding of CO to MgAl2O4. We believe that this finding regarding the origin of the CO selectivity of MgAl2O4 provides fundamental insight for the design methanation catalysts.
Program Desa Peduli Skizofrenia: Menuju ODGJ Berobat dan Taat Obat
Authors: Rahayu Retno , Muthia Dinni Siti 
Published: August 2021

Permasalahan gangguan jiwa yang terus meningkat akan berdampak pada banyak aspek di dunia. Luasnya permasalahan mengenai kesehatan mental sehingga membutuhkan perhatian dan kerjasama dari lintas sektor, baik pemerintah, stakeholder, keluarga dan masyarakat. Partisipan dalam penelitian aksi ini adalah keluarga orang dengan gangguan jiwa, stakeholder dan masyarakat umum di Desa X Kecamatan Kretek, Bantul, D.I. Yogyakarta. Tujuan dari penelitian ini adalah keluarga dan stakeholder lebih memahami cara pendampingan orang dengan gangguan jiwa serta mengupayakan pengobatan bagi orang dengan gangguan jiwa. Intervensi dilakukan dengan teknik psikoedukasi yang diberikan kepada keluarga dan stakeholder.
Kata kunci : skizofrenia, komunitas, psikoedukasi
Faktor-Faktor yang Mempengaruhi Pengembangan Teknologi Informasi Pemerintahan Desa (E-Gov) di Indonesia
Authors: Kurniansyah Dadan , Hannie Hannie 
Published: August 2021

Penelitian ini bertujuan untuk mengkaji pengembangan teknologi informasi yang dikembangkan Pemerintahan Desa dalam mengatasi permasalahan pemerintahan desa agar mampu mengoptimalkan pengembangan dan pemanfaatan teknologi informasi pemerintahan (e-Gov). Metode penelitian menggunakan metode kualitatif, analisis data kualitatif dan teknik pengumpulan data melalui interview, observasi dan studi dokumentasi. Hasil penelitian menunjukkan, visi Pemerintah Kabupaten Karawang sudah mendukung model pengembangan Sistem informasi pelaporan berbasis internet seperti Siskeudes-Prodeskel tapi belum menyentuh pengembangan layanan kepada masyarakat dan baru satu desa yang melaksanakan. Sumber daya manusia belum memenuhi standar yang diharapkan, salahsatunya adalah terputusnya kaderisasi SDM akibat Pilkades. Proses penyelenggaraan pelayanan pemerintah desa dalam e-gov baru dalam bentuk pelaporan saja bukan untuk informasi kepada masyarakat desa. Desa masih kekurangan dalam aksesibilitas dan jaringan, karena tidak semua zona atau wilayah di Desa mampu menangkap sinyal untuk internet dan mekanisme manajemen resiko dalam yang berkaitan dengan e-Gov sama sekali belum dibahas.Kata Kunci: Electronic Government (E-Gov), Pemerintahan Desa
Redesain Demokrasi Internal Partai Politik: Upaya Mencegah Oligarki dan Korupsi Partai Politik
Authors: Juniar Afif 
Published: August 2021

Partai politik menjadi komponen utama dalam sistem demokrasi dan memiliki tugas untuk mengartikulasikan kehendak publik, mengadakan pendidikan politik, mengembangkan dan menawarkan alternatif kebijakan serta menyediakan pilihan politik kepada masyarakat dalam pemilu. Namun praktik oligarki dan berkembangnya perilaku korupsi di tubuh partai politik yang saat ini banyak terjadi menjadi sebuah tantangan tersendiri dalam upaya mewujudkan tatanan ideal negara demokratis. Penelitian ini bertujuan untuk mengetahui praktik oligarki dan relasinya dengan tindakan korupsi dalam tubuh partai politik dan bagaimana upaya mencegah oligarki dan korupsi dalam partai politik (studi perbandingan Amerika Serikat, Inggris dan Korea Selatan). Metode penelitian yang digunakan adalah metode penelitian yuridis normative dengan studi perbandingan di beberapa negara. Penelitian ini dikaji berdasarkan Undang-Undang Nomor 2 Tahun 2011 tentang Partai Politik dan teori Oligarki Jeffrey A. Winters. Hasil penelitian menunjukkan redesain demokrasi internal parpol melalui proses rekrutmen dan kaderisasi secara ideal dapat menjadi jawaban dalam upaya mencegah praktik oligarki dan korupsi di tubuh parpol. Praktik proses rekrutmen dan kaderisasi parpol di Amerika Serikat, Inggris, dan Korea Selatan dapat menjadi pembelajaran yang baik dalam praktik rekrutmen dan kaderisasi parpol di Indonesia.
Thickness control and photovoltaic properties of CH3NH3PbI3 bar-coated thin film
Authors: Fujii Akihiko , Oizumi Tomohisa , Kuwahara Nao , Uzurano Genya , Saito Tomoki , Yabuuchi Yuta , Ozaki Masanori 
Published: August 2021

Abstract
Thin films of a typical organic–inorganic halide perovskite material, CH3NH3PbI3 (MAPbI3), were fabricated by a bar-coating method, which is one of the candidate techniques for large-scale production. The film thickness of MAPbI3 markedly changed depending on the sweep speed of the coating bar, that is, it decreased in evaporation regime under the low-speed condition, and increased in the Landau–Levich regime under the high-speed condition. The typical inverted-type p-i-n planar solar cells with the MAPbI3 thin films demonstrated the photoelectric conversion efficiency of 14.0%, and their photovoltaic properties depending on the sweep speed were discussed by taking the surface morphology and crystallinity into consideration.
PENGARUH DISIPLIN KERJA, KOMPENSASI, DAN PANDEMI COVID 19 TERHADAP PRODUKTIVITAS PT. INDAH ROTI BERSERI PALEMBANG
Authors: Kartikawaty Endang , Yustini Tien , Zamzam Fakhry 
Published: August 2021

. The purpose of this study was to determine the Effect of Work Discipline, Compensation and the Covid-19 Pandemic Climate on the Productivity of PT. Indah Roti Berseri, Palembang partially or simultaneously. This research method uses descriptive and verification surveys, field data collection uses questionnaires, interviews and documentation techniques. This research is an associative research, where in this study there are variables that are related and can influence other variables. The population of this study were 77 employees of PT. Indah Roti Berseri, Palembang. Data processing using SPSS 25 analysis tool. Testing the data using the t test, that work discipline has an effect on productivity with t count 11.967 > t table 1.9912 and a significance of 0.00 <0.05, there is a compensation effect on productivity with t count 6.941 > t table 1.9912 and a significance of 0 ,00 < 0.05 , the COVID-19 pandemic climate affects performance with t count 11.489 > t table 1.9912 significance 0.00> 0.05 and work discipline, compensation and organizational climate during the pandemic on productivity simultaneously with f count 70.424 > f table 2.72 significance 0.00> 0.05. The common thread of research is that work discipline, compensation and the climate of the COVID-19 pandemic affect the productivity of PT. Indah Roti Berseri, Palembang both partially and simultaneously. A strategy to increase productivity by continuing to build the company's organizational climate even during the Covid 19 Pandemic and maintaining work discipline and employee welfare through good compensation.
Conocimiento y manejo de las TIC por docentes de comercio y marketing
Authors: Soroa de Carlos María Patricia , Hernández Suárez María del Mar 
Published: August 2021

Actualmente y debido al estado de alarma sanitario producido por la COVID-19, fueron muchos los docentes que tuvieron y tienen que adaptarse a la nueva situación de aprendizaje teniendo que hacer frente, en poco tiempo, a las demandas de la Educación 2.0. La falta de ajuste de formación a las necesidades concretas del profesorado conlleva que, muchas veces, estos mismos profesionales tengan que adquirir conocimientos En la familia de Formación Profesional de Comercio y Marketing, nos encontramos en un contexto donde los docentes apenas han tenido tiempo para conocer y manejar las Tecnologías de la Información y la Comunicación.
BONE MINERAL DENSITY IN FEMALE MEDICAL STUDENTS RESIDING IN HOSTEL, A SINGLE-CENTER STUDY
Authors: Humayun Suqrat Hasan Imam  , Uzma Sagheer  , Tahir Ismail  , Muhammad Khalid Saddiqui  
Published: August 2021

BACKGROUND & OBJECTIVE: Osteopenia is a condition in which bone mineral density (BMD) is decreased. If not timely prevented, it can be aggravated to severe osteoporosis and a risk for fractures. Our objective was to find out the frequency of osteopenia and osteoporosis in female medical students residing in hostel of Punjab Medical College Faisalabad.
METHODOLOGY: A Cross-sectional study was conducted in Liaqat and Fatima hall of Punjab Medical College Hostel, Faisalabad from 1st June 2014 to 31st August 2014 after ethical review committee approval. By using non probability convenient sampling technique, 212 female students of MBBS residing in Punjab Medical College Hostel were included in study. Predesigned questionnaire was used to collect data. Data was analyzed by using 17 version of SPSS.
RESULTS: Out of 212 females, the age of 70 (33%) females was <20 years, the age of 80 (38%) females was 21-22 years and 62 (29%) females was ≥ 23 years. The frequency of osteoporosis was 81(38%), osteopenia was 123 (58%) and normal females were only 8 (4%). In relation to regular exercise, significant association was observed with p <0.001.
CONCLUSION: Frequency of osteopenia and osteoporosis was high among female medical students. To address this serious public health issues, health education should be provided.
Fe xvii 2p–3s Line Ratio Diagnostic of Shock Formation Radius in O Stars
Authors: Grell Gabriel J. , Leutenegger Maurice A. , Shah Chintan 
Published: August 2021

Abstract
The 2p–3s lines of Fe xvii in the X-ray spectrum of the O-type star ζ Puppis exhibit an anomalous (3G + M2)/(3F) line ratio of ∼1.4, in comparison with ∼2.4 for almost all other collisionally excited astrophysical spectra. Based on the work of Mauche et al., we conjectured that the strong UV field of ζ Puppis produces the observed ratio by depopulation of metastable 3s excited states, and that the ratio can potentially be used as an independent diagnostic of plasma formation radius. We used the Flexible Atomic Code collisional-radiative model to model the effect of UV photoexcitation from O stars on the Fe xvii lines. We compared our model calculations to archival spectra of coronal and hot stars from the Chandra HETGS and XMM-Newton RGS to benchmark our calculations for various electron densities and UV field intensities. Our calculations show that UV photoexcitation does not produce a sufficiently large dynamic range in the 3F / (3F + 3G + M2) fraction to explain the difference in the observed ratio between coronal stars and ζ Pup. Thus, this effect likely cannot explain the observed line ratio of ζ Pup, and its origin is still unexplained.
Physical Conditions in the LMC’s Quiescent Molecular Ridge: Fitting Non-LTE Models to CO Emission
Authors: Finn Molly K. , Indebetouw Remy , Johnson Kelsey E. , Costa Allison H. , Chen C.-H. Rosie , Kawamura Akiko , Onishi Toshikazu , Ott Jürgen , Tokuda Kazuki , Wong Tony , Zahorecz Sarolta 
Published: August 2021

Abstract
The Molecular Ridge in the LMC extends several kiloparsecs south from 30 Doradus, and it contains ∼30% of the molecular gas in the entire galaxy. However, the southern end of the Molecular Ridge is quiescent—it contains almost no massive star formation, which is a dramatic decrease from the very active massive-star-forming regions 30 Doradus, N159, and N160. We present new Atacama Large Millimeter/submillimeter Array and Atacama Pathfinder Experiment observations of the Molecular Ridge at a resolution as high as ∼16″ (∼3.9 pc) with molecular lines 12CO(1-0), 13CO(1-0), 12CO(2-1), 13CO(2-1), and CS(2-1). We analyze these emission lines with our new multiline non-LTE fitting tool to produce maps of T
kin,

n

H

2

, and N
CO across the region based on models from RADEX. Using simulated data for a range of parameter space for each of these variables, we evaluate how well our fitting method can recover these physical parameters for the given set of molecular lines. We then compare the results of this fitting with LTE and X
CO methods of obtaining mass estimates and how line ratios correspond with physical conditions. We find that this fitting tool allows us to more directly probe the physical conditions of the gas and estimate values of T
kin,

n

H

2

, and N
CO that are less subject to the effects of optical depth and line-of-sight projection than previous methods. The fitted

n

H

2

values show a strong correlation with the presence of young stellar objects (YSOs), and with the total and average mass of the associated YSOs. Typical star formation diagnostics, such as mean density, dense gas fraction, and virial parameter do not show a strong correlation with YSO properties.