bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating dissemination and implementation sciences within Clinical and Translational Science Award programs to advance translational research: Recommendations to national and local leaders
Authors: Mehta Tara G. , Mahoney Jane , Leppin Aaron L. , Stevens Kathleen R. , Yousefi-Nooraie Reza , Pollock Brad H. , Shelton Rachel C. , Dolor Rowena , Pincus Harold , Patel Sapana , Moore Justin B. 
Published: July 2021

Abstract
The National Center for Advancing Translational Sciences (NCATS) has defined translation as the process of turning observations into interventions that are adopted, sustained, and improve health. Translation must attend to research and community systems and context at multiple levels, and to key stakeholders. Dissemination and implementation (D&I) sciences are informed by an understanding of the critical role of people and systems in disseminating, adopting, and sustaining innovations within real-world settings. Thus, the D&I sciences provides a set of principles that can guide the translational work of Clinical and Translational Science Award (CTSA) programs from basic research to public health. In this special communication, our cross-domain working group of the CTSA consortium, comprised of experts in methods and processes, workforce development, evaluation, stakeholder engagement, and D&I sciences, share a vision of how CTSAs can enhance translation across the translational spectrum through the integration of D&I sciences into the critical areas of methods and processes, workforce development, and evaluation. We propose a set of recommendations for NCATS national and local leaders that are intended to move D&I sciences out of a position of unfamiliarity and ancillary value and into the core identity of who CTSAs are, how they think, and what they do, to advance translation and health.
Textural and geochemical characteristics of garnet from the Luoyang Fe skarn deposit, eastern China: implications for ore-forming fluid evolution and mineralization conditions
Authors: Wang Qiang , Yang Yu-Long , Tang Yao , Guo Wen-Qi , Xiao Tian-Xin 
Published: July 2021

AbstractThe late Palaeozoic Yong’an–Meizhou depression belt is an important iron (Fe) and polymetallic metallogenic belt in southern China. It has undergone a transformation from Tethys to the circum-Pacific tectonic domain. The Luoyang deposit is one of the typical Fe skarn deposits in the Yong’an–Meizhou depression belt of eastern China. Garnet is a characteristic mineral in the deposit. Two generations of garnets are detected in the deposit based on their textural characteristics and trace-element contents, and are represented by Fe-enriched andradite. The first generation of garnets (Grt1) have two types of garnets (Grt1-A and Grt1-B). Type A garnets of the first generation (Grt1-A) (Adr80-88) replaced by massive diopside-magnetite assemblage exhibit distinct oscillatory zonings and display patterns of enriched light rare earth elements (LREE) to weak heavy rare earth elements (HREE), with weak negative to positive Eu anomalies, and highest U, ΣREE and Sn contents. Type B garnets of the first generation (Grt1-B) are irregular zones (Adr94-96) coexisting with magnetite, in which Grt1-A is generally dissolved, and have obviously LREE-enriched and HREE-depleted patterns, with weak negative to positive Eu anomalies, and moderate U, ΣREE and Zn contents. Garnets of the second generation (Grt2) (Adr96-99) that replaced massive magnetite together with sphalerite show unzoned patterns, with a flat REE pattern and pronounced negative Eu anomalies as well as contents of lowest U and ΣREE, and highest W. The substitution of REEs in garnets occurs as [X2+]VIII –1[REE3+]VIII +1[Si4+]IV –1[Z3+]IV +1in an Al-enriched environment. Luoyang hydrothermal fluids shifted from reducing conditions with relatively high-U and -ΣREE characteristics to oxidizing conditions with relatively low-U and -ΣREE characteristics. The reduced siderophile elements and increased fO2 in fluid during Grt1-B formation caused magnetite mineralization and reduced Zn contents during Grt2 formation, causing the deposition of sphalerite. All garnets formed from magmatic fluid and were controlled by infiltrative metasomatism in an opened system.
The ageing of parent carers: classed and gendered care-giving patterns at higher ages
Authors: Henz Ursula 
Published: July 2021

AbstractIncreasing longevity has led to a rising number of adult children who are at higher ages when they provide care for their parents. Drawing on the lifecourse approach and exchange theory, the paper addresses similarities and differences in parent care between late middle-aged and older adult children. The study uses the UK Household Longitudinal Study, restricting the analysis sample to individuals aged 50 and older with a living parent or parent-in-law. It presents multivariate models to examine differences between late middle-aged (aged 50–64) and older (aged 65+) children in being a parent carer, providing intensive care, the duration of parent care and providing selected types of help to parents. The involvement in parent care increases among women up to the end of their seventh decade of life and for men up to their eighth decade of life. At higher ages, the proportion of parent carers decreases more strongly for women than men. Older carers have shorter care-giving episodes than younger carers, but there is no significant difference in the type of care provided. Even past retirement age, parent care remains classed and gendered, with women from lower social classes having the highest likelihood of providing intensive parent care in old age. Having dependent children or living in a non-marital union depress the likelihood of caring for a parent even past retirement age.
From Black to Blue Skies: Civil Society Perceptions of Air Pollution in Shanghai
Authors: Winter Amanda K. , Le Huong , Roberts Simon 
Published: July 2021

AbstractThis paper explores the perception and politics of air pollution in Shanghai. We present a qualitative case study based on a literature review of relevant policies and research on civil society and air pollution, in dialogue with air quality indexes and field research data. We engage with the concept of China's authoritarian environmentalism and the political context of ecological civilization. We find that discussions about air pollution are often placed in a frame that is both locally temporal (environment) and internationally developmentalist (economy). We raise questions from an example of three applications with different presentations of air quality index measures for the same time and place. This example and frame highlight the central role and connection between technology, data and evidence, and pollution visibility in the case of the perception of air pollution. Our findings then point to two gaps in authoritarian environmentalism research, revealing a need to better understand (1) the role of technology within this governance context, and (2) the tensions created from this non-participatory approach with ecological civilization, which calls for civil society participation.
A Scoping Review of Care Trajectories across Multiple Settings for Persons with Dementia
Authors: Kosteniuk Julie G. , Morgan Debra G. , Elliot Valerie , Froehlich Chow Amanda , Bayly Melanie , Watson Erin , Osman Meric , Acan Osman Beliz , O’Connell Megan E. , Kirk Andrew , Stewart Norma , Cammer Allison , Innes Anthea 
Published: July 2021

AbstractMultiple transitions across care settings can be disruptive for older adults with dementia and their care partners, and can lead to fragmented care with adverse outcomes. This scoping review was conducted to identify and classify care trajectories across multiple settings for people with dementia, and to understand the prevalence of multiple transitions and associated factors at the individual and organizational levels. Searches of three databases, limited to peer-reviewed studies published between 2007 and 2017, provided 33 articles for inclusion. We identified 26 distinct care trajectories. Common trajectories involved hospital readmission or discharge from hospital to long-term care. Factors associated with transitions were identified mainly at the level of demographic and medical characteristics. Findings suggest a need for investing in stronger community-based systems of care that may reduce transitions. Further research is recommended to address knowledge gaps about complex and longitudinal care trajectories and trajectories experienced by sub-populations of people living with dementia.
Tomato tolerance and purple nutsedge control with sulfuryl fluoride mixes
Authors: Yu Jialin , Freeman Joshua H. , Boyd Nathan S. 
Published: July 2021

AbstractSulfuryl fluoride (SF) is currently used as a fumigant for control of drywood termites and insects in building structures, vehicles, wood products, postharvest commodities, and food processing facilities. This research investigated the feasibility of using SF as a preplant soil fumigant for purple nutsedge control in plastic-mulched tomato production. SF treatments included SF injected through drip tapes or SF injected through drip tapes a few hours following shank injection of chloropicrin (Pic). Results revealed that SF alone at 224, 336, or 448 kg ha−1 was generally less effective compared with when it was applied in conjunction with Pic at 168 kg ha−1. SF alone provided inconsistent control of purple nutsedge. In contrast, SF + Pic was as efficacious or more efficacious on purple nutsedge than the industry standards, including 1,3-dichloropropene (1,3-D) plus Pic and metam potassium. None of the fumigant treatments visually injured tomato plants, stunted growth, or adversely affected tomato yield. In one of the four tomato seasons, tomato plants growing in plots fumigated with SF + Pic resulted in taller tomato plants and higher markable yields. Results indicate that soil fumigation with SF + Pic is safe on plastic-mulched tomato and effectively controls purple nutsedge.
Rising Seas, Rising Inequity? Communities at Risk in the San Francisco Bay Area and Implications for Adaptation Policy
Authors: Bick I. Avery , Santiago Tate Adrian F. , Serafin Katherine A. , Miltenberger Alex , Anyansi Ifeoma , Evans Max , Ortolano Leonard , Ouyang Derek , Suckale Jenny 
Published: July 2021

AbstractIncreasing coastal flooding threatens urban centers worldwide. Projections of physical damages to structures and their contents can characterize the monetary scale of risk, but they lack relevant socioeconomic context. The impact of coastal flooding on communities hinges not only on the cost, but on the ability of households to pay for the damages. Here, we repurpose probabilistic risk assessment to analyze the monetary and social risk associated with coastal flooding in the San Francisco Bay Area for 2020–2060. We show that future coastal flooding could financially ruin a substantial number of households by burdening them with flood damage costs that exceed discretionary household income. We quantify these impacts at the census block group scale by computing the percentage of households without discretionary income, before and after coastal flooding costs. We find that for several coastal communities in San Mateo County more than 50% of households will be facing financial instability, highlighting the need for immediate policy interventions that target existing, socially produced risk rather than waiting for potentially elusive certainty in sea level rise projections. We emphasize that the percentage of financially unstable households is particularly high in racially diverse and historically disadvantaged communities, highlighting the connection between financial instability and inequity. While our estimates are specific to the San Francisco Bay Area, our granular, household‐level perspective is transferable to other urban centers and can help identify the specific challenges that different communities face and inform appropriate adaptation interventions.
Geologic History and Crater Morphology of Asteroid (162173) Ryugu
Authors: Cho Y. , Morota T. , Kanamaru M. , Takaki N. , Yumoto K. , Ernst C. M. , Hirabayashi M. , Barnouin O. S. , Tatsumi E. , Otto K. A. , Schmitz N. , Wagner R. J. , Jaumann R. , Miyamoto H. , Kikuchi H. , Hemmi R. , Honda R. , Kameda S. , Yokota Y. , Kouyama T. , Suzuki H. , Yamada M. , Sakatani N. , Honda C. , Hayakawa M. , Yoshioka K. , Matsuoka M. , Michikami T. , Hirata N. , Sawada H. , Ogawa K. , Sugita S. 
Published: July 2021

AbstractCrater morphology and surface age of asteroid (162173) Ryugu are characterized using the high‐resolution images obtained by the Hayabusa2 spacecraft. Our observations reveal that the abundant boulders on and under the surface of the rubble‐pile asteroid affect crater morphology. Most of the craters on Ryugu exhibit well‐defined circular depressions, unlike those observed on asteroid Itokawa. The craters are typically outlined by boulders remaining on the rim. Large craters (diameter > 100 m) host abundant and sometimes unproportionally large boulders on their floors. Small craters (<20 m) are characterized by smooth circular floors distinguishable from the boulder‐rich exterior. Such small craters tend to have dark centers of unclear origin. The correlation between crater size and boulder number density suggests that some processes sort the size of boulders in the shallow (<30 m) subsurface. Furthermore, the crater size‐frequency distributions (CSFDs) of different regions on Ryugu record multiple geologic events, revealing the diverse geologic history on this 1‐km asteroid. Our crater‐counting analyses indicate that the equatorial ridge is the oldest structure of Ryugu and was formed 23–30 Myr ago. Then, Ryugu was partially resurfaced, possibly by the impact that formed the Urashima crater 5–12 Myr ago. Subsequently, a large‐scale resurfacing event formed the western bulge and the fossae 2–9 Myr ago. Following this process, the spin of Ryugu slowed down plausibly due to the YORP effect. The transition of isochrons in a CSFD suggests that Ryugu was decoupled from the main belt and transferred to a near‐Earth orbit 0.2–7 Myr ago.
Ionospheric Electron Density and Conductance Changes in the Auroral Zone During Substorms
Authors: Stepanov N. A. , Sergeev V. A. , Shukhtina M. A. , Ogawa Y. , Chu X. , Rogov D. D. 
Published: July 2021

AbstractEnhanced precipitation of magnetospheric energetic electrons during substorms increases ionospheric electron density and conductance. Such enhancements, which have timescales of a few hours, are not reproduced by the existing ionospheric models. We use the linear prediction filter (LPF) method to reconstruct the substorm‐related response of electron densities and integral conductances from long‐term ionospheric observations made by the European Incoherent SCATer radar located at Tromsø. To characterize the intensity of substorm dipolarization at a 5 min time step, we use the midlatitude positive bay index. We build response functions (LP filters) as a function of substorm time between T0−1 h and T0 + 4 h (T0 is a substorm onset time) in different magnetic local time (MLT) sectors to estimate the magnitude and delays of the ionospheric density response at different altitudes. Systematic and large relative changes are mostly observed in the D‐ and E regions. The duration of the response is about 3 h. It starts and reaches maximum magnitude near midnight, propagating from there toward the east and decaying after passing into the noon‐evening sector. The reliability of LPF results is confirmed by the consistency of D‐region response with independently derived response of the auroral absorption. Whereas strong ionization increases are seen in both E‐ and D‐regions on the nightside, the D‐region response is stronger in the morning‐dayside sector. Such MLT variation corresponds to the drift motion and precipitation of the high‐energy electrons injected in the nightside magnetosphere during substorm dipolarization. The inferred ionization changes result in strong enhancements of integral Hall (and Pedersen) conductance in the nightside auroral zone, where intense auroral currents are known to occur during substorms
Altered cortical thickness development in 22q11.2 deletion syndrome and association with psychotic symptoms
Authors: Bagautdinova Joëlle , Zöller Daniela , Schaer Marie , Padula Maria Carmela , Mancini Valentina , Schneider Maude , Eliez Stephan 
Published: July 2021

AbstractSchizophrenia has been extensively associated with reduced cortical thickness (CT), and its neurodevelopmental origin is increasingly acknowledged. However, the exact timing and extent of alterations occurring in preclinical phases remain unclear. With a high prevalence of psychosis, 22q11.2 deletion syndrome (22q11DS) is a neurogenetic disorder that represents a unique opportunity to examine brain maturation in high-risk individuals. In this study, we quantified trajectories of CT maturation in 22q11DS and examined the association of CT development with the emergence of psychotic symptoms. Longitudinal structural MRI data with 1–6 time points were collected from 324 participants aged 5–35 years (N = 148 22q11DS, N = 176 controls), resulting in a total of 636 scans (N = 334 22q11DS, N = 302 controls). Mixed model regression analyses were used to compare CT trajectories between participants with 22q11DS and controls. Further, CT trajectories were compared between participants with 22q11DS who developed (N = 61, 146 scans), or remained exempt of (N = 47; 98 scans) positive psychotic symptoms during development. Compared to controls, participants with 22q11DS showed widespread increased CT, focal reductions in the posterior cingulate gyrus and superior temporal gyrus (STG), and accelerated cortical thinning during adolescence, mainly in frontotemporal regions. Within 22q11DS, individuals who developed psychotic symptoms showed exacerbated cortical thinning in the right STG. Together, these findings suggest that genetic predisposition for psychosis is associated with increased CT starting from childhood and altered maturational trajectories of CT during adolescence, affecting predominantly frontotemporal regions. In addition, accelerated thinning in the STG may represent an early biomarker associated with the emergence of psychotic symptoms.
Shisa6 mediates cell-type specific regulation of depression in the nucleus accumbens
Authors: Kim Hee-Dae , Wei Jing , Call Tanessa , Quintus Nicole Teru , Summers Alexander J. , Carotenuto Samantha , Johnson Ross , Ma Xiaokuang , Xu Chenxi , Park Jin G. , Qiu Shenfeng , Ferguson Deveroux 
Published: July 2021

AbstractDepression is the leading cause of disability and produces enormous health and economic burdens. Current treatment approaches for depression are largely ineffective and leave more than 50% of patients symptomatic, mainly because of non-selective and broad action of antidepressants. Thus, there is an urgent need to design and develop novel therapeutics to treat depression. Given the heterogeneity and complexity of the brain, identification of molecular mechanisms within specific cell-types responsible for producing depression-like behaviors will advance development of therapies. In the reward circuitry, the nucleus accumbens (NAc) is a key brain region of depression pathophysiology, possibly based on differential activity of D1- or D2- medium spiny neurons (MSNs). Here we report a circuit- and cell-type specific molecular target for depression, Shisa6, recently defined as an AMPAR component, which is increased only in D1-MSNs in the NAc of susceptible mice. Using the Ribotag approach, we dissected the transcriptional profile of D1- and D2-MSNs by RNA sequencing following a mouse model of depression, chronic social defeat stress (CSDS). Bioinformatic analyses identified cell-type specific genes that may contribute to the pathogenesis of depression, including Shisa6. We found selective optogenetic activation of the ventral tegmental area (VTA) to NAc circuit increases Shisa6 expression in D1-MSNs. Shisa6 is specifically located in excitatory synapses of D1-MSNs and increases excitability of neurons, which promotes anxiety- and depression-like behaviors in mice. Cell-type and circuit-specific action of Shisa6, which directly modulates excitatory synapses that convey aversive information, identifies the protein as a potential rapid-antidepressant target for aberrant circuit function in depression.
Wet-dry cycles protect surface-colonizing bacteria from major antibiotic classes
Authors: Beizman-Magen Yana , Grinberg Maor , Orevi Tomer , Kashtan Nadav 
Published: July 2021

Abstract
Diverse antibiotic compounds are abundant in microbial habitats undergoing recurrent wet-dry cycles, such as soil, root and leaf surfaces, and the built environment. These antibiotics play a central role in microbial warfare and competition, thus affecting population dynamics and the composition of natural microbial communities. Yet, the impact of wet-dry cycles on bacterial response to antibiotics has been scarcely explored. Using the bacterium E. coli as a model organism, we show through a combination of experiments and computational modeling, that wet-dry cycles protect bacteria from beta-lactams. This is due to the combined effect of several mechanisms including tolerance induced by high salt concentrations and slow cell-growth, which are inherently associated with microscopic surface wetness—a hydration state typical to ‘dry’ periods. Moreover, we find evidence for a cross-protection effect, where lethal doses of antibiotic considerably increase bacterial survival during the dry periods. This work focuses on beta-lactams, yet similar protection was observed for additional major antibiotic classes. Our findings shed new light on how we understand bacterial response to antibiotics, with broad implications for population dynamics, interspecies interactions, and the evolution of antibiotic resistance in vast terrestrial microbial habitats.
Biosynthetic potential of uncultured Antarctic soil bacteria revealed through long-read metagenomic sequencing
Authors: Waschulin Valentin , Borsetto Chiara , James Robert , Newsham Kevin K , Donadio Stefano , Corre Christophe , Wellington Elizabeth 
Published: July 2021

Abstract
The growing problem of antibiotic resistance has led to the exploration of uncultured bacteria as potential sources of new antimicrobials. PCR amplicon analyses and short-read sequencing studies of samples from different environments have reported evidence of high biosynthetic gene cluster (BGC) diversity in metagenomes, indicating their potential for producing novel and useful compounds. However, recovering full-length BGC sequences from uncultivated bacteria remains a challenge due to the technological restraints of short-read sequencing, thus making assessment of BGC diversity difficult. Here, long-read sequencing and genome mining were used to recover &gt;1400 mostly full-length BGCs that demonstrate the rich diversity of BGCs from uncultivated lineages present in soil from Mars Oasis, Antarctica. A large number of highly divergent BGCs were not only found in the phyla Acidobacteriota, Verrucomicrobiota and Gemmatimonadota but also in the actinobacterial classes Acidimicrobiia and Thermoleophilia and the gammaproteobacterial order UBA7966. The latter furthermore contained a potential novel family of RiPPs. Our findings underline the biosynthetic potential of underexplored phyla as well as unexplored lineages within seemingly well-studied producer phyla. They also showcase long-read metagenomic sequencing as a promising way to access the untapped genetic reservoir of specialised metabolite gene clusters of the uncultured majority of microbes.