bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increasing Functional Measurement Tool Utilization by Acute Physical Therapists
Authors: Betts Traci Tiemann , Davis Kristin , Palagonia Christie , Walag Homer B. 
Published: December 2021

Background:
At an acute academic medical center, an electronic medical record (EMR) clarity report revealed that proper documentation of a functional measurement tool during acute physical therapy (PT) initial evaluation and reevaluation sessions occurred only 12% of the time. A formal quality improvement project was initiated to correct this gap in recommended best practice.

Objective:
To increase utilization and documentation of functional measurement tools in acute PT evaluation and reevaluation sessions from baseline of 12% to 100% based on the APTA recommendations for best standard of care in clinical practice.

Methods:
This quality improvement project involved acute PT staff and faculty in an academic medical center assessing a gap in best practice. Barriers to best clinical practice were assessed and targeted interventions included education and awareness of baseline performance compared with expectations, streamlining usability of the EMR documentation flowsheet and creating resources to address gaps in knowledge, performance, or access to available functional tools. Data were collected at project initiation, midterm, and after final interventions through manual chart reviews, EMR clarity reports, and a custom PT staff survey.

Results:
Documentation of functional measurements tools improved from the baseline of 12% to 89.5% after full project interventions. Follow-up survey results indicated that PTs' perception of providing the highest quality of care increased by 29 percentage points, from 71% to 100%. Improved diversity of tool usage was also noted. Of the tools documented, Activity Measure for Post-Acute Care (AMPAC) functional measurement tool was selected 90% of the time at baseline and dropped to 66% post-intervention, allowing for a 24% increase in diversity of tool selection.

Conclusions:
Accurate discovery of the primary and secondary factors impacting tool use with targeted interventions yielded a 7.5-fold improvement (from 12% to 89.5%) in performance and documentation of functional measurement tools during PT evaluation and reevaluation sessions in the acute care setting. The project also highlighted limitations of education alone in effectively promoting adherence to best practice standards. The increased utilization and documentation of functional measurement tools has improved PT practice in this academic medical center through more objective detection of functional changes across the continuum. It should also promote targeted PT interventions, which should improve PT effectiveness and potentially even impact hospital length of stay.
Stroke-Specific Refinements to Naylor's Transitional Care Model to Address the Storm of Uncertainty and Unmet Survivor and Caregiver Needs
Authors: Laws Lorre , Ritter Leslie , Loescher Lois , McEwen Marylyn 
Published: December 2021

ABSTRACT

BACKGROUND: By 2030, there will be approximately 7.6 million stroke survivors (SSs) in the United States, yet comprehensive transitional care (TC) for stroke is not widely available. Stroke strikes without warning and leaves in its wake a “storm” of uncertainty for SSs and caregivers (CGs) as they encounter a myriad of unmet physical, mental, emotional, and financial needs that are not wholly addressed by passive healthcare delivery systems. Needed is a stroke-specific TC model that bridges this storm to active delivery of SS and CG postacute care. Naylor's Transitional Care Model (NTCM) has not been examined for how it can frame comprehensive stroke care. The purpose of this study was to solicit SS and CG descriptions of TC experiences to inform the NTCM with refined operational definitions and exemplars specific to stroke. METHODS: Focus groups conducted for this qualitative descriptive study were guided by interview questions based on the 8 NTCM operational definitions. Data were analyzed using inductive and deductive qualitative content analysis methods. RESULTS: Post–acute-stroke care does not comprehensively meet the needs of SSs and CGs. Participants described TC deficits across all 8 NTCM components. Two new subcomponents that could be applied for a stroke-specific NTCM emerged: psychological and transportation challenges. CONCLUSION: Unmet needs identified by SSs and CGs were used to extend NTCM specific to the stroke population and to develop the Recommendations and Exemplars for Stroke Specific Comprehensive Transitional Care Delivery (see Supplementary Digital Content, available at http://links.lww.com/JNN/A385). Researchers and practitioners can use the findings to develop and deliver more comprehensive TC to SSs and CGs.
Drug-coated balloon versus drug-eluting stent in acute myocardial infarction
Authors: Geng Baoyu , Liu Zhe , Feng Guangzhi , Jiang Jun 
Published: December 2021

Abstract

Background:
Previous studies comparing the published literature on drug-eluting stents (DES) and drug-coated balloon (DCB) have drawn divergent conclusions, as these studies are limited by small sample sizes. To overcome these limitations, we thus conducted a high-quality systematic review and meta-analysis to assess the efficacy and safety of DCB versus DES for patients with acute myocardial infarction (AMI). It was hypothesized that DCB use at the AMI is associated with decreased risk of cardiovascular disease and death.

Methods:
The electronic databases Embase, Medline, PubMed, and Cinahl were searched from the earliest available date until August 2021. Study included in our study had to meet all of the following inclusion criteria: all randomized controlled trials to assess the efficacy and safety of DES versus DCB in the treatment of AMI were considered eligible for analysis; participants received DCB or DES; reporting the available data on cardiac death, all-cause death, myocardial infarction, target lesion revascularization, target vessel revascularization, major adverse cardiac events, and stent thrombosis. Review Manager Software (v 5.3; Cochrane Collaboration) was used for the meta-analysis. Two of us independently assessed the risk of bias in the included studies using parameters defined in the Cochrane Handbook for Systematic Reviews of Interventions criteria.

Results:
It was hypothesized that DCB use at the AMI is associated with decreased risk of cardiovascular disease and death.

Registration number:
10.17605/OSF.IO/AVTYW.
Visual analysis on the research of monocarboxylate transporters based on CiteSpace
Authors: Li Feifei , Wang Shuqi , Yao Youlong , Sun Xueming , Wang Xiaoyan , Wang Ning , You Yulin , Zhang Yanli 
Published: December 2021

Abstract

Background:
Monocarboxylate transports (MCTs), a family of solute carrier protein, play an important role in maintenance of cellular stability in tumor cells by mediating lactate exchange across membranes. The objective of this paper is to evaluate the knowledge structure, development trend, and research hotspot of MCTs research field systematically and comprehensively.

Methods:
Based on the 1526 publications from 2010 to 2020 retrieved from “Web of Science Core Collection” (WoSCC), we visually analyzed the MCTs research in terms of subject category, scientific collaboration network, keywords, and high-frequency literature using CiteSpace.

Results:
The number of publications exhibits an upward trend from 2010 to 2020 and the top 5 countries in the MCTs research were the United States, China, Japan, Germany, and England. Visser TJ was the most prolific author, while Halestrap AP was the most influential author with the highest citations. Analysis of the 7 cluster units from the co-cited references and keywords revealed that high expression of MCTs induced by oxidative stress and glycolysis was the pivotal point in the MCTs research field, while regulation of metabolism in tumor microenvironment, prognostic markers of cancer, and targeted inhibitors are the top 3 research frontiers topics.

Conclusion:
This study will help the new researcher to understand the MCTs related field, master the research frontier, and obtain valuable scientific information, thus providing directions for follow-up research.
Genome-wide association study identifies BTNL2 associated with atopic asthma in children
Authors: Kim Soo Yeon , Kim Eun Gyul , Kim Mina , Hong Jung Yeon , Kim Ga Eun , Jung Jae Hwa , Park Mireu , Kim Min Jung , Kim Yoon Hee , Sohn Myung Hyun , Kim Kyung Won 
Published: December 2021

Abstract
Asthma is a heterogeneous disease characterized by chronic airway inflammation with a genetic predisposition. Butyrophilin-like 2 (BTNL2) is a member of the immunoglobulin superfamily that plays an important role in regulating T cell activation and immune homeostasis. Here, we aimed to investigate the association of the genetic variants of BTNL2 with childhood asthma and asthma-related traits by utilizing extreme asthma phenotypes and employing a genome-wide association study. Our study included 243 children with well-defined moderate to severe atopic asthma and 134 healthy children with no history of allergic diseases and allergic sensitization. DNA from these subjects was genotyped using AxiomTM Genome-Wide Array Plates. Although no single nucleotide polymorphisms (SNPs) reached a genome-wide threshold of significance, 3 SNPs, rs3817971, rs41355746, and rs41441651, at BTNL2 were significantly associated with moderate to severe atopic asthma after performing Bonferroni correction. These SNPs were also associated with the risk of allergic sensitization toward house dust mites and the presence and degree of bronchial hyperresponsiveness. Thus, we identified that BTNL2 was associated with atopic moderate to severe persistent asthma in Korean children, and this may play an important role in disease development and susceptibility.
Risks for bicycle-related injuries in Al Ain city, United Arab Emirates
Authors: Grivna Michal , AlKatheeri Ahmed , AlAhbabi Mohammed , AlKaabi Saeed , Alyafei Mohammed , Abu-Zidan Fikri M. 
Published: December 2021

Abstract
Traffic-related injuries are a serious health problem. Traffic safety is a priority reflected in the United Nations Sustainable Development Goals. Data on current hazards for bicycle-related injuries from the United Arab Emirates are lacking. The aim of our observational study was to assess the behavior of bicyclists on the roads in Al Ain City, United Arab Emirates and compare our current results with a previous study from 2004.
We adapted and tested a structured data collection form. Different sectors of Al Ain were randomly selected to cover the whole city during different times. Bicyclists were observed without direct contact.
Out of 1129 bicyclists, 97.6% were males and 13.2% children. 39.4% were cycling on main roads with high-density traffic, 33.1% were cycling against the traffic, 39.3% were cycling at night, and 96.8% of them were not using lights. Only 2.1% of the bicyclists used helmets. A higher proportion of female than male cyclists used helmets (25.9% vs 1.5%; P < .001, Fisher exact test). There was an increase in cycling with the traffic (P < .001) and in use of helmets (P < .025) compared with the previous study.
Unsafe practices of bicyclists and low use of helmets despite legislation persist in Al Ain. There is a need to raise bicycle safety awareness and improve enforcement of bicycle helmet legislation. This should be directed toward expatriate workers, children, parents, and maids. Environmental changes, namely building separate bicycle lanes, can increase safety for cycling.
Clinical predictive score for detecting nonalcoholic fatty liver disease with significant fibrosis in patients with metabolic syndrome
Authors: Kositamongkol Chayanis , Charernboon Thammanard , Chaisathaphol Thanet , Washirasaksiri Chaiwat , Auesomwang Chonticha , Sitasuwan Tullaya , Charatcharoenwitthaya Phunchai , Phisalprapa Pochamana 
Published: December 2021

Abstract
Patients with metabolic syndrome are at a higher risk of nonalcoholic fatty liver disease (NAFLD) and liver fibrosis than the general population. Still, accessibility of screening method for NAFLD with significant fibrosis, such as transient elastography (FibroScan) are limited in some settings. This study aimed to develop a simple clinical predictive score for detecting NAFLD with significant fibrosis in patients with metabolic syndrome.
A cross-sectional study was designed to obtain the data from medical records of all relevant patients who underwent transient elastography between January 2011 and December 2020 at Siriraj Hospital, Thailand. A liver stiffness cutoff value of 7.0 kilopascal was used to define the presence of significant liver fibrosis. To examine potential predictors, medical history and clinical data commonly assessed in routine practice were selected by following expert opinions and univariable statistical analysis. Backward and forward stepwise logistic regression was performed to acquire a final prediction model. To simplify the model, a weighted score was assigned for each categorized predictor. In addition, eligible cutoff values of the score and their predictive performances were determined.
A total of 745 medical records were reviewed. The prevalence of NAFLD with significant fibrosis in patients with metabolic syndrome was 12.6%. Most clinical characteristics of patients with NAFLD with significant fibrosis and those non-NAFLD and NAFLD with no/mild fibrosis were quite disparate. The most practical model comprised globulin, aspartate transaminase, platelet count, and type 2 diabetes. It provided a good predictive performance with an area under the receiver operating characteristic curve of 0.828 (95% confidence interval [CI]: 0.782, 0.874). At the proper cutoff value, sensitivity and specificity were 76.6% (95% CI: 66.7%, 84.7%) and 72.4% (95% CI: 68.7%, 75.8%), respectively. The likelihood ratio of testing positive for NAFLD with significant fibrosis was 2.8 (95% CI: 2.34, 3.27) among patients with scores above the cutoff value.
The first score for detecting of NAFLD with significant fibrosis in patients with metabolic syndrome was developed. This practical score, providing a good predictive performance, should be useful to help clinicians prioritize needs for further investigations among high-risk patients, especially in resource-limited settings.
Evaluation of previous management against a developed clinical pathway for chronic rhinosinusitis with nasal polyposis in Universiti Kebangsaan Malaysia Medical Center
Authors: Wong Timothy LW , Husain Salina , Ismail Aniza , Zahedi Farah Dayana , Aljunid Syed Mohamed , Nur Amrizal Muhammad 
Published: December 2021

Abstract
The study aims to evaluate previous management of CRSwNP patients in Universiti Kebangsaan Malaysia Medical Center (UKMMC) against a developed CP.
Chronic rhinosinusitis with nasal polyposis (CRSwNP) has high economic burden and impacts patient's quality of life. Implementation of clinical pathway (CP) can standardize care while optimizing resources.
Analytical cross-sectional
This study utilized medical records of 103 CRSwNP patients at UKMMC otorhinolaryngology clinic from 2010 to 2015. Patients were divided into groups who underwent or did not undergo surgery. Information was obtained regarding sociodemographic, follow-ups, pharmaceutical regimes, and treatment cost. Cost analysis was done using top-down analysis and activity-based costing and CP was formulated. Cost was calculated using year 2020 rates to adjust for inflation. (United States Dollars [USD]1 = Ringgit Malaysia [RM] 4.2015)
Study showed non-CP patients were undertreated compared to CP. This affects clinical outcomes as optimal treatment demanded by CP was not achieved. Total cost for non-CP, non-surgery patients were lower (USD660) compared to CP (USD780) due to under treatment and shorter follow-ups. Meanwhile, total cost for non-CP surgery patients were higher (USD3600) compared to CP (USD2706) due to longer visit durations and hospital stays. Non-CP surgery group underwent lengthy follow-up duration (20.7 months) prior to operation compared to 12 months expected in CP.
Study showed non-CP patients were undertreated compared to CP. We identified aspects which resulted in resource wastage and unnecessary burden to our healthcare system. This study enables development of a written CP by fine-tuning various aspects of CP which could be applied to our future practice.
The efficacy of Chinese herbal medicine Buyang Huanwu Decoction combined with acupuncture to treat sequela of apoplexy
Authors: Zhang Jiayu , Li Zhaowei , Zhang Liang 
Published: December 2021

Abstract

Background:
Stroke is a common disease in neurology, patients often have different degrees of sequelae, which affect the patient's quality of life. We conducted a protocol for systematic review and meta-analysis to assess the efficacy of Buyang Huanwu Decoction combined with acupuncture for the treatment of stroke sequelae.

Methods:
The current protocol is prepared in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Protocols statement guideline. Seven electronic databases including Web of Science, Embase, PubMed, Wanfang Data, Scopus, Science Direct, and Cochrane Library were searched in August 2021 by 2 independent reviewers. The risk of bias assessment of the included studies was performed by 2 authors independently using the tool recommended in the Cochrane Handbook for Systematic Reviews of Interventions (version 5.1.0). We will perform meta-analysis using STATA 11.0 (http://www.stata.com; Stata Corporation, College Station, TX).

Results:
The review will add to the existing literature by showing compelling evidence and improved guidance in clinic settings.

Conclusion:
Buyang Huanwu Decoction combined with acupuncture seems to be an effective therapy to ameliorate the clinical symptoms of stroke sequelae. In order to further determine the effectiveness and safety of Buyang Huanwu Decoction combined with acupuncture in treating stroke sequelae, more multicenter and prospective randomized controlled trials must be carried out.
Efficacy of acupuncture combined with Chinese herbal medicine for the treatment of chronic nephritis
Authors: Zheng Xue , Zhang Shoulin , Wang Zhilei , Zou Di 
Published: December 2021

Abstract

Background:
Chronic nephritis is a common kidney disease that afflicts people worldwide. The disease has main manifestations of proteinuria, hematuria, edema, and hypertension that are associated with kidney-damaging processes that eventually lead to kidney failure. Traditional Chinese medicine involving combination treatment with herbal remedies and acupuncture has been shown clinically to alleviate chronic nephritis, although to date no systematic review of the efficacy of this combination treatment for this purpose has been reported, prompting this study. Here we conducted a systematic review and meta-analysis of published randomized clinical trials to scientific evidence and credible medical references supporting the clinical efficacy of this combination treatment when used to treat chronic nephritis.

Methods:
We will search the following 8 electronic Chinese and English databases: Web of Science, PubMed, Cochrane Library, Embase, China Biomedical Literature Database, China National Knowledge Infrastructure, China Scientific Journal Database, and the Wanfang database. All electronic databases will be searched from inception to October 10, 2021. All statistical analyses will be performed using Review Manager Version 5.4 provided by the Cochrane Collaboration Network.

Results:
The protocol for systematic review and meta-analysis will be applied to evaluate the efficacy of acupuncture combined with Chinese herbal medicine for the treatment of chronic nephritis.

Conclusion:
We plan to submit the results of this research to a peer-reviewed journal.

INPLASY registration number:
INPLASY2021100051.
The effects of traditional Chinese manual therapy (Tuina) for chronic fatigue syndrome
Authors: Ren Jun , He Tianxiang , Zhou Xin , Wu Zhiwei , Kong Lingjun 
Published: December 2021

Abstract

Background:
Chronic fatigue syndrome (CFS) is a common disease and characterized by fatigue, exhaustion, heavy limbs, and dizziness. Tuina, as a traditional Chinese manual therapy, is usually used for CFS in China. Several studies have reported that Tuina can improve fatigue exhaustion, and dizziness of patients with CFS. However, the effects of Tuina for CFS still remain controversial. Therefore, the current systematic review and meta-analysis will be conducted to investigate the effects of Tuina in the management of CFS.

Methods:
The comprehensive electronic search of PubMed, Web of Science, Chinese National Knowledge Infrastructure, Wanfang Database, Embase, Cochrane Library, Chinese Science Citation Database, Technology Periodical Database from their inception to October 2021 will be conducted. Randomized controlled trials of Tuina for CFS will be included in the review. Two independent reviewers will complete the study selection, data extraction, and the risk of bias. The meta-analysis will be conducted using the Review Manager Version 5.3 software. The heterogeneity will be assessed using the I

2
statistic and Q statistic. The standardized mean difference and 95% confidence intervals will be calculated based on different heterogeneity. The subgroup analysis will be conducted based on the duration of treatment, age, gender, duration of CFS. Quality of evidence will be assessed using the Grades of Recommendation, Assessment, Development and Evaluation.

Results:
The current systematic review and meta-analysis will be to investigate the effects of Tuina in the management of CFS.

Conclusion:
The conclusion of this study will provide the evidence for the treatment of CFS in the future. It is expected that the conclusions drawn from this review will benefit patients, clinical practitioners and policy makers.
Effects of cupping therapy for obesity
Authors: Kim Hyungsuk , Kim Koh-Woon , Chung Won-Seok 
Published: December 2021

Abstract

Background:
Obesity is a prevalent disease in modern society. Despite the various interventions available in conventional medicine, their success rates are not satisfactory because of the complex mechanisms involved in obesity. Cupping therapy is a traditional Chinese medicinal intervention, and it has become widely used in various clinical settings for the treatment of obesity. This systematic review and meta-analysis will investigate the effects of cupping on obesity.

Methods:
Three Korean databases (KoreaMed, Oriental Medicine Advanced Searching Integrated System, and ScienceON), 1 Japanese database (Citation Information by the National Institute of Informatics), 1 Chinese database (Chinese National Knowledge Infrastructure), MEDLINE/PubMed, EMBASE, and The Cochrane Central Register of Controlled Trials will be searched for studies published until March 2021. The primary outcome is body weight. The secondary outcomes will be body mass index, waist-hip ratio, waist circumference, hip circumference, body fat mass, body fat percentage, and adverse events.

Results:
This systematic review and meta-analysis will evaluate the effects of cupping therapy for obesity.

Conclusion:
The results of this systematic review and meta-analysis will then be discussed in a related journal for clinicians working with obese patients to apply the interventions in this article.

Trial registration number:
DOI 10.17605/OSF.IO/P8JVM (https://osf.io/p8jvm).