bluuebunny/crossref_metadata_2025_split huggingface dataset:
Política de Superación de la Extrema Pobreza en Chile
Authors: Dauvin Herrera Cristóbal Osmán 
Published: October 2021

En Chile los programas de acompañamiento psicosocial intervienen a familias en condición de extrema pobreza desde un modelo que establece como principal satisfactor la relación entre el profesional apoyo familiar y las familias. Desde 2002 se han atendido 1.017.127 familias. El propósito de este estudio es caracterizar a los actores involucrados en programas de acompañamiento psicosocial pertenecientes al sistema de protección social en Chile, a través de un análisis documental de contenido de cuatro manuales de trabajo, metodológicos y orientaciones técnicas. Los principales resultados establecen que durante los 18 años de ejecución de esta estrategia los principales actores son las familias y el Estado, con la incorporación del mercado como asignador de protección social y, más recientemente, la comunidad como unidad de intervención y espacio de integración social.
Corvus: Uma solução Sandbox e de Threat Intelligence para Identificação e Análise de Malware
Authors: Botacin Marcus , Ceschin Fabrício , Grégio André 
Published: October 2021

Neste artigo, apresentamos Corvus, uma solução web para a identificação, triagem e análise de ameaças. Através da plataforma, usuários podem submeter arquivos PDF e executáveis Android, Linux e Windows desconhecidos para procedimentos de análise estática, dinâmica e de análise de dados. Os dados obtidos são reportados através de tabelas, gráficos dinâmicos e podem ser exportados em formatos adequados para a utilização por equipes de resposta à incidentes de segurança. Disponível em https://corvus.inf.ufpr.br/.
Implantation du programme Lanterne en milieux éducatifs : une analyse qualitative des perceptions des éducatrices en petite enfance
Authors: Fortin Andréanne , Julien Marily , Hébert Martine , Dion Jacinthe , Cyr Mireille 
Published: October 2021

Le programme Lanterne vise à prévenir la violence sexuelle et s’adresse aux enfants d’âge préscolaire ainsi qu’aux adultes qui gravitent autour d’eux. Cette étude vise à recueillir 1) les perceptions des personnes éducatrices concernant l’utilisation des outils pédagogiques du programme auprès des enfants et 2) l’expérience subjective des personnes-ressources qui agissent à titre de Lanterne. Selon les personnes interrogées, les outils sont très appréciés des tout-petits et le programme est adapté à leur niveau développemental. Les personnes Lanterne ont aussi observé des retombées positives du programme sur leur pratique professionnelle, elles rapportent notamment accorder un plus grand respect à l’intimité des jeunes enfants. Finalement, les données recueillies permettent d’offrir des recommandations en vue d’assurer la pérennité du programme.
How Not to Study a Disease
Authors: Herrup Karl 
Published: October 2021

An authority on Alzheimer's disease offers a history of past failures and a roadmap that points us in a new direction in our journey to a cure.
For decades, some of our best and brightest medical scientists have dedicated themselves to finding a cure for Alzheimer's disease. What happened? Where is the cure? The biggest breakthroughs occurred twenty-five years ago, with little progress since. In How Not to Study a Disease, neurobiologist Karl Herrup explains why the Alzheimer's discoveries of the 1990s didn't bear fruit and maps a direction for future research. Herrup describes the research, explains what's taking so long, and offers an approach for resetting future research.
Herrup offers a unique insider's perspective, describing the red flags that science ignored in the rush to find a cure. He is unsparing in calling out the stubbornness, greed, and bad advice that has hamstrung the field, but his final message is a largely optimistic one. Herrup presents a new and sweeping vision of the field that includes a redefinition of the disease and a fresh conceptualization of aging and dementia that asks us to imagine the brain as a series of interconnected “neighborhoods.” He calls for changes in virtually every aspect of the Alzheimer's disease research effort, from the drug development process, to the mechanisms of support for basic research, to the often-overlooked role of the scientific media, and more. With How Not to Study a Disease, Herrup provides a roadmap that points us in a new direction in our journey to a cure for Alzheimer's.
Media Disrupted
Authors: Lotz Amanda D. 
Published: October 2021

How the internet disrupted the recorded music, newspaper, film, and television industries and what this tells us about surviving technological disruption.
Much of what we think we know about how the internet “disrupted” media industries is wrong. Piracy did not wreck the recording industry, Netflix isn't killing Hollywood movies, and information does not want to be free. In Media Disrupted, Amanda Lotz looks at what really happened when the recorded music, newspaper, film, and television industries were the ground zero of digital disruption. It's not that digital technologies introduced “new media,” Lotz explains; rather, they offered existing media new tools for reaching people.
For example, the MP3 unbundled recorded music; as the internet enabled new ways for people to experience and pay for music, the primary source of revenue for the recorded music industry shifted from selling music to licensing it. Cable television providers, written off as predigital dinosaurs, became the dominant internet service providers. News organizations struggled to remake businesses in the face of steep declines in advertiser spending, while the film industry split its business among movies that compelled people to go to theaters and others that are better suited for streaming. Lotz looks in detail at how and why internet distribution disrupted each industry. The stories of business transformation she tells offer lessons for surviving and even thriving in the face of epoch-making technological change.
Hormonal changes of intimate partner violence perpetrators in response to brief social contact with women
Authors: van der Meij Leander , Pulopulos Matias M. , Hidalgo Vanesa , Almela Mercedes , Lila Marisol , Roney James R. , Salvador Alicia 
Published: October 2021

AbstractThis study investigated whether men with a history of real‐life aggressive, dominant behavior show increases in testosterone and cortisol levels after brief social contact with women. Furthermore, we tested the prediction that such changes in hormones would be larger than those observed previously in young male students. Sixty‐seven male participants convicted of intimate partner violence (IPV) either had brief social contact with a female confederate (experimental condition) or a male confederate (control condition). We also performed meta‐analyses to investigate whether IPV perpetrators' hormonal responses were larger than the typical responses of young male students in prior studies. All statistical analyses were preregistered. Change in testosterone did not differ across experimental conditions, and testosterone in the IPV perpetrators actually declined from baseline in the female confederate condition. Our meta‐analysis showed that this testosterone decrease was different from the testosterone increase typically observed in young male students. The cortisol levels of IPV perpetrators did not change in response to contact with women. This result was consistent with our meta‐analysis since young male students also did not experience a cortisol change in response to interactions with women. In sum, our findings provide no evidence that male IPV perpetrators exhibit larger hormone increases to brief interactions with women, although it is possible that the men in this sample did not perceive the social contact period as a courtship opportunity. These results suggest that hormone reactivity to social encounters may differ across subject populations and depend on how subjects perceive social situations within laboratory settings.
The effect of evidence order on jurors' verdicts: Primacy and recency effects with strongly and weakly probative evidence
Authors: Schweitzer Kimberly , Nuñez Narina 
Published: October 2021

AbstractIn a series of studies, the effect of evidence order with strongly and weakly probative evidence was examined. In studies 1a, 1b, and 2, participants read a homicide trial containing four pieces of evidence (two strongly probative, two weakly) presented in differing orders and reported their verdicts. In Study 1a and 1b, fingerprint evidence and a video confession were strongly probative, while DNA evidence and eyewitness testimony were not. In Study 2, DNA and video confession evidence were strongly probative, but fingerprint evidence and eyewitness testimony were not. Across studies, results indicated recency effects when the last piece of evidence was strongly probative, with more guilty verdicts compared to when the last piece of evidence was weakly probative. Study 3 utilized a different trial scenario and six pieces of evidence to further test for a primacy effect. Results again indicated support for a recency effect, with no primacy effects found.
Finite‐time and fixed‐time synchronization of fuzzy Clifford‐valued Cohen‐Grossberg neural networks with discontinuous activations and time‐varying delays
Authors: Aouiti Chaouki , Bessifi Mayssa 
Published: October 2021

SummaryIn this article, we are concerned with fuzzy Clifford‐valued Cohen‐Grossberg neural networks (FCVCGNNs) via discontinuous activations and time‐varying delays. First, the time‐delayed feedback strategy is used to investigate the synchronization in finite‐time and fixed‐time of FCVCGNNs with discontinuous activations and time‐varying delays. By designing Lyapunov functions and utilizing differential inequalities, several effective conditions are derived to ensure synchronization in finite‐time and fixed‐time of the addressed neural networks. A novel fixed‐time convergence method is proposed to study synchronization in fixed‐time of discontinuous delayed FCVCGNNs. Furthermore, the settling time of synchronization are estimated. In the end, two numerical examples with simulations are given to confirm the effectiveness of the synchronization criteria.
Paper‐Like Writable Nanoparticle Network Sheets for Mask‐Less MOF Patterning
Authors: Bo Renheng , Taheri Mahdiar , Chen Hongjun , Bradford Jonathan , Motta Nunzio , Surve Sachin , Tran‐Phu Thanh , Garg Puneet , Tsuzuki Takuya , Falcaro Paolo , Tricoli Antonio 
Published: October 2021

AbstractGeometrical structuring of monolithic metal‐organic frameworks (MOFs) components is required for their practical implementation in many areas, including electronic devices, gas storage/separation, catalysis, energy storage as well as bio‐medical applications. Despite progress in structuring MOFs, an approach for the precise patterning of MOF functional geometries in the millimeter‐ to micro‐meter depth is lacking. Here, a facile and flexible concept for the microfabrication of complex MOF patterns on large surfaces is reported. The method relies on the engineering of easily‐writable sheets of precursor metal oxide nanoparticles. The gas‐phase conversion of these patterned ceramic nanoparticle sheets results in monolithic MOF objects with arbitrarily shaped geometries and thicknesses of up to hundreds of micrometers. The writing of complex patterns of zeolitic imidazolate framework‐8 (ZIF‐8) is demonstrated by a variety of approaches including ion beam, laser, and hand writing. Nanometer‐scale patterns are achieved by focused ion beam (FIB). Artless handwritings are obtained by using a pen in a similar fashion to writing on a paper. The pure ZIF‐8 composition of the resulting patterns is confirmed by a series of physical and chemical characterization. This facile MOF precursor‐writing approach provides novel opportunities for the design of MOF‐based devices with applications ranging from micro‐fluidics to renewable energy systems.
A Self‐Healable Sulfide/Polymer Composite Electrolyte for Long‐Life, Low‐Lithium‐Excess Lithium‐Metal Batteries
Authors: Ren Yuxun , Cui Zehao , Bhargav Amruth , He Jiarui , Manthiram Arumugam 
Published: October 2021

AbstractSolid electrolyte‐protected lithium‐metal anodes promise energy‐dense, safe cells. While sulfide solid electrolytes enable facile processability and fast ion transport, they suffer from complex chemo‐mechanical issues, including Li plating‐induced fracture and Li stripping‐induced contact loss. To address these issues, a grafting approach is implemented to functionalize the sulfide solid electrolyte (Li3,85Sn0.85Sb0.15S4) with a self‐healing unit. This leads to a dynamic bonding between the solid electrolyte network and a mechanically robust polymer scaffold, which reversibly accommodates the volume changes of the lithium‐metal anode. Moreover, the approach improves the interfacial contact between the lithium‐metal anode and the composite electrolyte, enabling stable cycling at a mild stack pressure (160 kPa). With a negative to positive capacity ratio equals to 1, pouch full cells with a high‐nickel cathode (nickel content > 90%) and lithium‐metal anode display 92% capacity retention for 140 cycles. Engineering the interface between solid electrolyte and the polymeric binder offers a promising pathway to address the chemo‐mechanical issues.
Ultrasensitive Molecular Sensors Based on Real‐Time Impedance Spectroscopy in Solution‐Processed 2D Materials
Authors: Moore David C. , Jawaid Ali , Busch Robert , Brothers Michael , Miesle Paige , Miesle Adam , Rao Rahul , Lee Jonghoon , Beagle Lucas K. , Motala Michael , Wallace Shay Goff , Downing Julia R. , Roy Ajit , Muratore Christopher , Hersam Mark C. , Vaia Richard , Kim Steve , Glavin Nicholas R. 
Published: October 2021

AbstractChemical sensors based on solution‐processed 2D nanomaterials represent an extremely attractive approach toward scalable and low‐cost devices. Through the implementation of real‐time impedance spectroscopy and development of a three‐element circuit model, redox exfoliated MoS2 nanoflakes demonstrate an ultrasensitive empirical detection limit of NO2 gas at 1 ppb, with an extrapolated ultimate detection limit approaching 63 ppt. This sensor construct reveals a more than three orders of magnitude improvement from conventional direct current sensing approaches as the traditionally dominant interflake interactions are bypassed in favor of selectively extracting intraflake doping effects. This same approach allows for an all solution‐processed, flexible 2D sensor to be fabricated on a polyimide substrate using a combination of graphene contacts and drop‐casted MoS2 nanoflakes, exhibiting similar sensitivity limits. Finally, a thermal annealing strategy is used to explore the tunability of the nanoflake interactions and subsequent circuit model fit, with a demonstrated sensitivity improvement of 2× with thermal annealing at 200 °C.
Molecular Cleavage of Metal‐Organic Frameworks and Application to Energy Storage and Conversion
Authors: Zhou Xianlong , Jin Huanyu , Xia Bao Yu , Davey Kenneth , Zheng Yao , Qiao Shi‐Zhang 
Published: October 2021

AbstractThe physicochemical properties of metal‐organic frameworks (MOFs) significantly depend on composition, topology, and porosity, which can be tuned via synthesis. In addition to a classic direct synthesis, postsynthesis modulations of MOFs, including ion exchange, installation, and destruction, can significantly expand the application. Because of a limitation of the qualitative hard and soft acids and bases (HSAB) theory, posttreatment permits regulation of MOF structure by cleaving chemical bonds at the molecular level. Here, methods of coordination bond scission to tailor the structure are critically appraised and the application to energy storage and conversion is assessed. MOF structures synthesized by molecular‐level coordination bond cleavage are described and the corresponding MOFs for electrocatalysis and renewable battery applications are evaluated. Significant emphasis is placed on various coordination bond cleavage to tune properties, including chemical groups, electronic structures, and morphologies. The review concludes with a critical perspective on practical application, together with challenges and future outlook for this emerging field.
Dimethylaminomicheliolide Sensitizes Cancer Cells to Radiotherapy for Synergistic Combination with Immune Checkpoint Blockade
Authors: Li Yingying , Ni Kaiyuan , Chan Christina , Guo Nining , Luo Taokun , Han Wenbo , Culbert August , Weichselbaum Ralph R. , Lin Wenbin 
Published: October 2021

AbstractRadiotherapy (RT) has demonstrated synergy with immune checkpoint blockade (ICB) in preclinical models. However, its potential as an immunoadjuvant is limited by low immunogenicity at low radiation doses and immunosuppression at high radiation doses. It is hypothesized that radiosensitizers can enhance both the anticancer and immunogenic effects of low‐dose radiation. Herein the authors report the antitumor immunity of combined RT and immunotherapy with dimethylaminomicheliolide (DMAMCL), a prodrug of the anti‐inflammatory sesquiterpene lactone micheliolide (MCL). DMAMCL sensitized cancer cells to a single fraction of RT in vitro by inducing apoptosis and DNA double‐strand breaks. DMAMCL with 5 fractions of 2 Gy focal X‐ray irradiation led to significant anticancer efficacy in subcutaneous and spontaneous models of murine cancer. DMAMCL‐sensitized RT upregulated programmed death‐ligand 1 (PD‐L1) expression in the tumors. Combination of DMAMCL‐sensitized RT with anti‐PD‐L1 ICB significantly enhanced antitumor efficacy by increasing tumor‐infiltrating CD4+ and CD8+ T cells and establishing immune memory.
Large Magnetoresistance in Scandium Nitride Magnetic Tunnel Junctions Using First Principles
Authors: Karki Suyogya , Rogers Vivian , Jadaun Priyamvada , Marshall Daniel S. , Incorvia Jean Anne C. 
Published: October 2021

AbstractThe state‐of‐the‐art magnetic tunnel junction, a cornerstone of spintronic devices and circuits, uses a magnesium oxide tunnel barrier that provides a uniquely large tunnel magnetoresistance at room temperature. However, the wide bandgap and band alignment of magnesium oxide‐iron systems increases the resistance‐area product and creates variability and breakdown challenges. Here, the authors study using first principles narrower‐bandgap scandium nitride (ScN) transport properties in magnetoresistive junctions in comparison to magnesium oxide. The results show a high magnetoresistance in Fe/ScN/Fe via Δ1 and symmetry filtering with low wave function decay rates, suggesting scandium nitride could be a new barrier material for spintronic devices.
Patient‐Derived Organoids Can Guide Personalized‐Therapies for Patients with Advanced Breast Cancer
Authors: Chen Ping , Zhang Xu , Ding Renbo , Yang Linglin , Lyu Xueying , Zeng Jianming , Lei Josh Haipeng , Wang Lijian , Bi Jiong , Shao Nan , Shu Ditian , Wu Bin , Wu Jingbo , Yang Zhihui , Wang Haiyan , Wang Biqiong , Xiong Kang , Lu Yun , Fu Shaozhi , Choi Tak Kan , Lon Ng Wai , Zhang Aiping , Tang Dongyang , Quan Yingyao , Meng Ya , Miao Kai , Sun Heng , Zhao Ming , Bao Jiaolin , Zhang Lei , Xu Xiaoling , Shi Yanxia , Lin Ying , Deng Chuxia 
Published: October 2021

AbstractMost breast cancers at an advanced stage exhibit an aggressive nature, and there is a lack of effective anticancer options. Herein, the development of patient‐derived organoids (PDOs) is described as a real‐time platform to explore the feasibility of tailored treatment for refractory breast cancers. PDOs are successfully generated from breast cancer tissues, including heavily treated specimens. The microtubule‐targeting drug‐sensitive response signatures of PDOs predict improved distant relapse‐free survival for invasive breast cancers treated with adjuvant chemotherapy. It is further demonstrated that PDO pharmaco‐phenotyping reflects the previous treatment responses of the corresponding patients. Finally, as clinical case studies, all patients who receive at least one drug predicate to be sensitive by PDOs achieve good responses. Altogether, the PDO model is developed as an effective platform for evaluating patient‐specific drug sensitivity in vitro, which can guide personal treatment decisions for breast cancer patients at terminal stage.
Non‐Volatile Photo‐Switch Using a Diamond pn Junction
Authors: Masante Cédric , Kah Martin , Hébert Clément , Rouger Nicolas , Pernot Julien 
Published: October 2021

AbstractUltrawide bandgap semiconductor technologies offer potentially revolutionary advances in the rapidly developing areas of quantum communication, short wavelength optics, smart energy conversion, and biomedical interfaces. These strongly demanding technologies can be partly constructed using conventional devices but new hybrid architectures are needed to overpass current performances and add functionalities. Here, a new concept based on the specific properties of a diamond pn junction combined with both an electric and optical control of the depletion region is proposed. Using this junction as a gate in a junction field effect transistor, a proof of concept of a non‐volatile diamond photo‐switch is reported. A diamond pn junction made with nitrogen deep donors in the n‐side is demonstrated to be optically activated thanks to visible light. The n‐type diamond gate is almost devoid of free carriers in the dark and thus insulating. Illuminating the device renders the standard electrical gate control of the transistor efficient. Without illumination, the device is frozen, keeping a permanent memory of the current state. This new way of operating the device opens numerous possibilities to store and transfer information or energy with applications in the field of electrical aircraft or aerospace electronics, power electronics, bio‐electronics, and quantum communication.
Quantifying and Suppressing Proton Intercalation to Enable High‐Voltage Zn‐Ion Batteries
Authors: Wang Fei , Blanc Lauren E. , Li Qin , Faraone Antonio , Ji Xiao , Chen‐Mayer Huaiyu H. , Paul Rick L. , Dura Joseph A. , Hu Enyuan , Xu Kang , Nazar Linda F. , Wang Chunsheng 
Published: October 2021

AbstractRechargeable Zn‐ion batteries (ZIBs) are widely regarded as promising candidates for large‐scale energy storage applications. Like most multivalent battery systems (based on Zn, Mg, Ca, etc.), further progress in ZIB development relies on the discovery and design of novel cathode hosts capable of reversible Zn2+ (de)intercalation. Herein, this work employs VPO4F as a ZIB cathode and explores ensuing intercalation mechanisms along with interfacial dynamics during cycling to quantify the water dynamics in concentrated electrolytes and/or hybrid aqueous‐non aqueous (HANEs) electrolyte(s). Like most oxide‐based cathode materials, proton (H+) intercalation dominates electrochemical activity during discharge of ZnxHyVPO4F in aqueous media due to the hydroxylated nature of the interface. Such H+ electrochemistry diminishes low‐rate and/or long‐term electrochemical performance of ZIBs which inhibits implementation for practical applications. Thus, quantification of the water dynamics in various electrolytes is demonstrated for the first time. Detailed investigations of water mobility in various concentrated electrolytes and HANEs systems enable the design of an electrolyte that enhances aqueous anodic stability and suppresses water/proton activity during discharge. Tuning Zn2+/H+ intercalation kinetics simultaneously allows for a high voltage (1.9 V) and long‐lasting aqueous zinc‐ion battery: Zn|Zn(OTf)2·nH2O‐PC|ZnxHyVPO4F.