bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Framework for Analysing Ecological Fiscal Transfers: Case Studies from the Brazilian Atlantic Forest
Authors: Verde Selva Gracie , Pauli Natasha , Clifton Julian , Kiatkoski Kim Milena 
Published: March 2021

AbstractThis article proposes a framework for evaluating the development and evolution of economic instruments for environmental conservation through the examination of their design and the interactional and structural aspects of their implementation. The framework is applied to comparatively describe the historical evolution of the world's longest-running ecological fiscal transfer (EFT) scheme in two Brazilian sites. Results show that while legislative aspects of programme design, such as linkages and flexibility, are crucial for performance, interactional and structural characteristics during implementation, such as capacity, knowledge-sharing and transparency, can be determining factors in how the programme functions at the municipal level. Policy recommendations are provided for the development of this type of programme elsewhere. Results contribute towards the conceptual understanding of EFTs, an under-utilised mechanism with great potential for a role in conservation policy mixes.
Mid-term follow-up of aortic valve replacement for bicuspid aortic valve
Authors: Liu Lingchao , Li Tianbo , Xu Bo , Liu Chencheng , Tang Fuqin , Xiao Yingbin , Wang Yong 
Published: March 2021

AbstractObjective:The purpose of this study was to evaluate the mid-term outcome of aortic valve replacement for bicuspid aortic valve and tricuspid aortic valve and the related risk factors.Methods:From January 2014 to June 2019, 177 tricuspid aortic valve patients and 101 bicuspid aortic valve patients who underwent aortic valve replacement in our hospital were collected. 1:1 propensity score matching analysis was used to control the bias in patient selection. The perioperative and follow-up data between the two groups were compared. Independent risk factors which were associated with the continued dilatation of the ascending aorta were identified by univariate or multivariate logistic regression analysis.Results:After the matching procedure, 160 patients were included in the analysis (80 in each group). Baseline characteristics, intraoperative, and perioperative outcomes were similar between the two groups (all p > 0.05). Moreover, 67 patients in the tricuspid aortic valve group and 70 in the bicuspid aortic valve group completed the follow-up. The ascending aorta change, annual change rate, and the proportion of continuous dilation of ascending aorta in bicuspid aortic valve group were significantly higher than those in the tricuspid aortic valve group (p < 0.05). Multivariate logistic regression analysis showed that type 1 in bicuspid aortic valve (OR 5.173; 95% CI 1.772, 15.101; p = 0.003), aortic regurgitation (OR 3.673; 95% CI 1.133, 11.908; p = 0.030), and aortic valve stenosis with regurgitation (OR 6.489; 95% CI 1.726, 24.404; p = 0.006) were independent risk factors for the continued dilatation of the ascending aorta in all AV patients. Furthermore, the multivariate logistic regression analysis showed that type 1 in bicuspid aortic valve (OR 5.157; 95% CI 1.053, 25.272; p = 0.043), age ≥ 40 years (OR 6.956; 95% CI 1.228, 39.410; p = 0.028), and aortic regurgitation (OR 4.322; 95% CI 1.174, 15.911; p = 0.028) were independent risk factors for the continued dilatation of the ascending aorta in bicuspid aortic valve patients.Conclusion:Compared with tricuspid aortic valve patients, the ascending aorta of bicuspid aortic valve patients is more likely to continue to enlarge after aortic valve replacement. Type 1 in bicuspid aortic valve, age ≥ 40 years, and aortic regurgitation were the independent risk factors.
Radiotherapy of tongue cancer using an intraoral stent: a pilot study
Authors: Bø Berit , Furre Torbjørn , Dale Einar 
Published: March 2021

AbstractAim:The aim was to evaluate the feasibility of an intraoral stent (10 and 20 mm thickness) in radiotherapy of tongue cancer, and to measure the reduction in acute mucositis in the palate.Materials and method:There were six patients in the intervention group, and seven patients in the control group. Target coverage was measured by the minimum dose covering 98% of the clinical target volume (CTV). Data were collected from the planning CT and daily cone-beam computer tomography (CBCT).Results:The 10 and 20 mm stent yielded a mean distance of 26 and 36 mm, respectively, between the tongue and the hard palate. We found comparable dose coverage of the CTV in the treatment plan, and on the CBCT. The stent reduced mean dose to the hard palate by 61.0% (p = 0.002). Dose to the soft palate was not reduced (p = 0.18). Average Common Terminology Criteria for Adverse Events (CTCAE) mucositis scores of the hard palate were 0 and 0.8 in the intervention and control group, respectively. The mucositis scores of the soft palate were 1.2 and 1.8.Findings:Use of an intraoral stent substantially reduced the dose to the hard palate. CTV coverage was maintained. We did not find any significant reduction in visually scored radiation-induced mucositis.
Delirium documentation in hospitalized pediatric patients with cancer
Authors: Lastrapes Kelly , Dang Malisa , Cassel J. Brian , Orr Tamara , Proffitt Tracye , Del Fabbro Egidio 
Published: March 2021

AbstractObjectiveScreening tools for delirium are being used more consistently in pediatric critical care. However, screening is not universal, and delirium may be underdiagnosed, misdiagnosed, or undocumented in hospitalized patients. We evaluated the identification and documentation of delirium in pediatric oncology and bone marrow transplant patients.MethodA retrospective chart review on all hospitalized pediatric oncology and bone marrow transplant patients admitted to an Academic Cancer center between 2013 and 2016. Patients aged less than 21 years of age with active cancer were included. Patients with major psychiatric conditions, developmental delays, or autism were excluded. Data were collected to characterize documentation concerning the identification and diagnosis of delirium.ResultsOf 201 hospitalization records, 54 (26.9%) admissions from 109 unique patients had documentation of delirium. The overall documented incidence of delirium was 3.2% of hospitalizations or 8.2% of unique patients. Patients prescribed opioids and benzodiazepines were more likely to have documentation of delirium. ICD coding under-reported delirium while physician documentation was inaccurate in 26% (53/201) when compared with the chart review.Significance of resultsDelirium was frequently undocumented or miscoded. Implementing a validated, universal screening tool for delirium may improve identification and clinical outcomes.
Fully integrated three-way LDMOS Doherty PAs for 1.8–2.2 GHz dual-band and 2.6 GHz m-MIMO 5G applications
Authors: Vigneau Marc , Ercoli Mariano , Maroldt Stephan 
Published: March 2021

AbstractThis paper presents a fully integrated three-way Doherty architecture to address the challenges of 5G applications using laterally-diffused metal-oxide semiconductor (LDMOS) technology. By using the so-called CDS cancelation method for the Doherty combiner design, a wideband impedance transformation is achieved, that combined with the three-way Doherty power amplifier (DPA) architecture allows for high efficiency in deep back-off, with a reduced load modulation for high bandwidth. Throughout this paper, the design approach and realization are described, while multiple critical design challenges will be addressed such as low frequency drain resonance optimization, impact of in-package coupling effects, and linearity versus efficiency tradeoff. Two state-of-the-art three-way fully integrated LDMOS DPA monolithic microwave integrated circuit (MMICs) are presented to demonstrate how these measures have been successfully applied to different power amplifier (PA) line-up components for 5G base station systems. First, a 60 W 1.8–2.2 GHz multi-stage device for driver application in true dual-band operation is presented. The circuit design pays special attention to extended PA video bandwidth thanks to integrated passive device. After digital pre-distortion (DPD) in dual-band operation, this highly linear device achieves an outstanding adjacent channel leakage ratio (ACLR) of −56 dBc for a 2cLTE 20 MHz 8 dB peak-to-average ratio signal spaced by 345 MHz, thus 385 MHz instantaneous bandwidth (IBW), with 29% efficiency at 35 dBm, 12 dB output back-off (OBO). Second, the simulation and measurement results of a 55 W 2.6 GHz multi-stage DPA for massive-MIMO final stage application are presented, which yields an excellent linearized efficiency of 49% using a 200 MHz 10cLTE signal with an ACLR lower than −47.5 dBc. For 8cLTE 20 MHz (160 MHz IBW), the device yields 50% efficiency with −50.7 dBc ACLR linearized after DPD. The achieved efficiency is well comparable to published GaN DPAs. These results were achieved by improved simulation techniques to minimize frequency dispersion and thus allow high efficiency operation over wide bandwidth. Both devices show that LDMOS is not only a mature technology which allows those PAs to be reliable and low-cost for mass production in very compact packages, but also provide best-in-class RF performance according to the needs of 5G base station systems.
FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma
Authors: Hao Yilong , Xiao Yanxuan , Liao Xiaoyu , Tang Shuya , Xie Xiaoyan , Liu Rui , Chen Qianming 
Published: March 2021

AbstractOral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and with 354 864 new cases each year. Cancer metastasis, recurrence, and drug resistance are the main causes to cripples and deaths of OSCC patients. As potent growth factors, fibroblast growth factors (FGFs) are frequently susceptible to being hijacked by cancer cells. In this study, we show that FGF8 is upregulated in OSCC tissues and high FGF8 expression is related with a set of clinicopathologic parameters, including age, drinking, and survival time. FGF8 treatment enhances the invasive capability of OSCC cells. Lentivirus-based FGF8 expression promotes OSCC metastasis in a mouse lung metastasis model. Further, mechanistic study demonstrates that FGF8 induces epithelial–mesenchymal transition (EMT) in OSCC cells. These results highlight a pro-metastatic function of FGF8, and underscore the role of FGF8 in OSCC development.
Multicomponent SF6 decomposition product sensing with a gas-sensing microchip
Authors: Chu Jifeng , Yang Aijun , Wang Qiongyuan , Yang Xu , Wang Dawei , Wang Xiaohua , Yuan Huan , Rong Mingzhe 
Published: March 2021

AbstractA difficult issue restricting the development of gas sensors is multicomponent recognition. Herein, a gas-sensing (GS) microchip loaded with three gas-sensitive materials was fabricated via a micromachining technique. Then, a portable gas detection system was built to collect the signals of the chip under various decomposition products of sulfur hexafluoride (SF6). Through a stacked denoising autoencoder (SDAE), a total of five high-level features could be extracted from the original signals. Combined with machine learning algorithms, the accurate classification of 47 simulants was realized, and 5-fold cross-validation proved the reliability. To investigate the generalization ability, 30 sets of examinations for testing unknown gases were performed. The results indicated that SDAE-based models exhibit better generalization performance than PCA-based models, regardless of the magnitude of noise. In addition, hypothesis testing was introduced to check the significant differences of various models, and the bagging-based back propagation neural network with SDAE exhibits superior performance at 95% confidence.
TGFβ/cyclin D1/Smad-mediated inhibition of BMP4 promotes breast cancer stem cell self-renewal activity
Authors: Yan Gang , Dai Meiou , Zhang Chenjing , Poulet Sophie , Moamer Alaa , Wang Ni , Boudreault Julien , Ali Suhad , Lebrun Jean-Jacques 
Published: March 2021

AbstractBasal-like triple-negative breast cancers (TNBCs) display poor prognosis, have a high risk of tumor recurrence, and exhibit high resistance to drug treatments. The TNBC aggressive features are largely due to the high proportion of cancer stem cells present within these tumors. In this study, we investigated the interplay and networking pathways occurring between TGFβ family ligands in regulating stemness in TNBCs. We found that TGFβ stimulation of TNBCs resulted in enhanced tumorsphere formation efficiency and an increased proportion of the highly tumorigenic CD44high/CD24low cancer stem cell population. Analysis of the TGFβ transcriptome in TNBC cells revealed bone morphogenetic protein4 (BMP4) as a main TGFβ-repressed target in these tumor cells. We further found that BMP4 opposed TGFβ effects on stemness and potently decreased cancer stem cell numbers, thereby acting as a differentiation factor in TNBC. At the molecular level, we found that TGFβ inhibition of BMP4 gene expression is mediated through the Smad pathway and cyclin D1. In addition, we also found BMP4 to act as a pro-differentiation factor in normal mammary epithelial cells and promote mammary acinar formation in 3D cell culture assays. Finally, and consistent with our in vitro results, in silico patient data analysis defined BMP4 as a potential valuable prognosis marker for TNBC patients.
The long noncoding RNA TINCR promotes breast cancer cell proliferation and migration by regulating OAS1
Authors: Lu Die , Di Shihao , Zhuo Shuaishuai , Zhou Linyan , Bai Rumeng , Ma Tianshi , Zou Zigui , Chen Chunni , Sun Miaomiao , Tang Jinhai , Zhang Zhihong 
Published: March 2021

AbstractBreast cancer is the leading cause of cancer-related death in women around the world. It is urgently needed to identify genes associated with tumorigenesis and prognosis, as well as to elucidate the molecular mechanisms underlying the oncogenic process. Long noncoding RNAs (lncRNAs) are widely involved in the pathological and physiological processes of organisms and play an important role as oncogenes or tumor suppressor genes, affecting the development and progression of tumors. In this study, we focused on terminal differentiation-induced non-coding RNA (TINCR) (GeneID:257000) and explore its role in the pathogenesis of breast cancer. The results showed that TINCR was increased in breast cancer tissue, and high expression level of TINCR was associated with older age, larger tumor size, and advanced TNM stage. High level of TINCR can promote proliferation and metastasis of breast cancer cells, while downregulation of TINCR induces G1-G0 arrest and apoptosis. Mechanismly, TINCR can bind to staufen1 (STAU1) and then guide STAU1 (GeneID:6780) to bind to OAS1 mRNA (NM_016816.4) to mediate its stability. Thus low level of OAS1(GeneID:4938) can lead to cell proliferation and migration. This result elucidates a new mechanism for TINCR in breast cancer development and provides a survival indicator and potential therapeutic target for breast cancer patients.
DNA stability: a central design consideration for DNA data storage systems
Authors: Matange Karishma , Tuck James M. , Keung Albert J. 
Published: March 2021

AbstractData storage in DNA is a rapidly evolving technology that could be a transformative solution for the rising energy, materials, and space needs of modern information storage. Given that the information medium is DNA itself, its stability under different storage and processing conditions will fundamentally impact and constrain design considerations and data system capabilities. Here we analyze the storage conditions, molecular mechanisms, and stabilization strategies influencing DNA stability and pose specific design configurations and scenarios for future systems that best leverage the considerable advantages of DNA storage.
Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis
Authors: Kwon Oh Sung , Mishra Rahul , Safieddine Adham , Coleno Emeline , Alasseur Quentin , Faucourt Marion , Barbosa Isabelle , Bertrand Edouard , Spassky Nathalie , Le Hir Hervé 
Published: March 2021

AbstractExon junction complexes (EJCs) mark untranslated spliced mRNAs and are crucial for the mRNA lifecycle. An imbalance in EJC dosage alters mouse neural stem cell (mNSC) division and is linked to human neurodevelopmental disorders. In quiescent mNSC and immortalized human retinal pigment epithelial (RPE1) cells, centrioles form a basal body for ciliogenesis. Here, we report that EJCs accumulate at basal bodies of mNSC or RPE1 cells and decline when these cells differentiate or resume growth. A high-throughput smFISH screen identifies two transcripts accumulating at centrosomes in quiescent cells, NIN and BICD2. In contrast to BICD2, the localization of NIN transcripts is EJC-dependent. NIN mRNA encodes a core component of centrosomes required for microtubule nucleation and anchoring. We find that EJC down-regulation impairs both pericentriolar material organization and ciliogenesis. An EJC-dependent mRNA trafficking towards centrosome and basal bodies might contribute to proper mNSC division and brain development.
Momentum-resolved visualization of electronic evolution in doping a Mott insulator
Authors: Hu Cheng , Zhao Jianfa , Gao Qiang , Yan Hongtao , Rong Hongtao , Huang Jianwei , Liu Jing , Cai Yongqing , Li Cong , Chen Hao , Zhao Lin , Liu Guodong , Jin Changqing , Xu Zuyan , Xiang Tao , Zhou X. J. 
Published: March 2021

AbstractHigh temperature superconductivity in cuprates arises from doping a parent Mott insulator by electrons or holes. A central issue is how the Mott gap evolves and the low-energy states emerge with doping. Here we report angle-resolved photoemission spectroscopy measurements on a cuprate parent compound by sequential in situ electron doping. The chemical potential jumps to the bottom of the upper Hubbard band upon a slight electron doping, making it possible to directly visualize the charge transfer band and the full Mott gap region. With increasing doping, the Mott gap rapidly collapses due to the spectral weight transfer from the charge transfer band to the gapped region and the induced low-energy states emerge in a wide energy range inside the Mott gap. These results provide key information on the electronic evolution in doping a Mott insulator and establish a basis for developing microscopic theories for cuprate superconductivity.
Integration of full divertor detachment with improved core confinement for tokamak fusion plasmas
Authors: Wang L. , Wang H. Q. , Ding S. , Garofalo A. M. , Gong X. Z. , Eldon D. , Guo H. Y. , Leonard A. W. , Hyatt A. W. , Qian J. P. , Weisberg D. B. , McClenaghan J. , Fenstermacher M. E. , Lasnier C. J. , Watkins J. G. , Shafer M. W. , Xu G. S. , Huang J. , Ren Q. L. , Buttery R. J. , Humphreys D. A. , Thomas D. M. , Zhang B. , Liu J. B. 
Published: March 2021

AbstractDivertor detachment offers a promising solution to the challenge of plasma-wall interactions for steady-state operation of fusion reactors. Here, we demonstrate the excellent compatibility of actively controlled full divertor detachment with a high-performance (βN ~ 3, H98 ~ 1.5) core plasma, using high-βp (poloidal beta, βp > 2) scenario characterized by a sustained core internal transport barrier (ITB) and a modest edge transport barrier (ETB) in DIII-D tokamak. The high-βp high-confinement scenario facilitates divertor detachment which, in turn, promotes the development of an even stronger ITB at large radius with a weaker ETB. This self-organized synergy between ITB and ETB, leads to a net gain in energy confinement, in contrast to the net confinement loss caused by divertor detachment in standard H-modes. These results show the potential of integrating excellent core plasma performance with an efficient divertor solution, an essential step towards steady-state operation of reactor-grade plasmas.
Thermochromic aggregation-induced dual phosphorescence via temperature-dependent sp3-linked donor-acceptor electronic coupling
Authors: Wang Tao , Hu Zhubin , Nie Xiancheng , Huang Linkun , Hui Miao , Sun Xiang , Zhang Guoqing 
Published: March 2021

AbstractAggregation-induced emission (AIE) has proven to be a viable strategy to achieve highly efficient room temperature phosphorescence (RTP) in bulk by restricting molecular motions. Here, we show that by utilizing triphenylamine (TPA) as an electronic donor that connects to an acceptor via an sp3 linker, six TPA-based AIE-active RTP luminophores were obtained. Distinct dual phosphorescence bands emitting from largely localized donor and acceptor triplet emitting states could be recorded at lowered temperatures; at room temperature, only a merged RTP band is present. Theoretical investigations reveal that the two temperature-dependent phosphorescence bands both originate from local/global minima from the lowest triplet excited state (T1). The reported molecular construct serves as an intermediary case between a fully conjugated donor-acceptor system and a donor/acceptor binary mix, which may provide important clues on the design and control of high-freedom molecular systems with complex excited-state dynamics.
Molecular correlates of muscle spindle and Golgi tendon organ afferents
Authors: Oliver Katherine M. , Florez-Paz Danny M. , Badea Tudor Constantin , Mentis George Z. , Menon Vilas , de Nooij Joriene C. 
Published: March 2021

AbstractProprioceptive feedback mainly derives from groups Ia and II muscle spindle (MS) afferents and group Ib Golgi tendon organ (GTO) afferents, but the molecular correlates of these three afferent subtypes remain unknown. We performed single cell RNA sequencing of genetically identified adult proprioceptors and uncovered five molecularly distinct neuronal clusters. Validation of cluster-specific transcripts in dorsal root ganglia and skeletal muscle demonstrates that two of these clusters correspond to group Ia MS afferents and group Ib GTO afferent proprioceptors, respectively, and suggest that the remaining clusters could represent group II MS afferents. Lineage analysis between proprioceptor transcriptomes at different developmental stages provides evidence that proprioceptor subtype identities emerge late in development. Together, our data provide comprehensive molecular signatures for groups Ia and II MS afferents and group Ib GTO afferents, enabling genetic interrogation of the role of individual proprioceptor subtypes in regulating motor output.