bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prophylactic Phenylephrine Increases the Dose Requirement of Oxytocin to Treat Uterine Atony During Cesarean Delivery: A Double-Blinded, Single-Center, Randomized and Placebo-Controlled Trial
Authors: Shen Yao-Hua , Yang Fan , Jin Li-Dan , Qian Yu-Jia , Xing Li , Huang Ya-Li , Lin Su-Feng , Xiao Fei 
Published: October 2021

Purpose: Studies involving mouse models and human uterine smooth muscle cells have shown that phenylephrine inhibits uterine contractions in non-pregnant mice and human in vitro cell via cyclic adenosine monophosphate (cAMP) signaling. However, there has been no limited exploration to date of the effect of phenylephrine on uterine contractions in clinical practice. This study aimed to compare the dose requirement of oxytocin with or without the infusion of prophylactic phenylephrine to prevent post spinal hypotension during cesarean delivery under combined spinal and epidural anesthesia.Methods: This was a double-blinded, single-center, randomized, control study. One hundred and sixty pregnant patients provided informed consent and were randomly allocated to the phenylephrine (phenylephrine infusion) and control (saline infusion) groups. Patients randomized to the phenylephrine group received an intravenous prophylactic phenylephrine infusion at a fixed rate of 0.5 μg/kg/min. The control group received a saline placebo at the same rate and used the same apparatus for delivery. After neonatal delivery and clamping of the umbilical cord, patients received a standard institutional oxytocin protocol. The primary outcome measure was the total dose of oxytocin administered during CD. Secondary outcomes including the proportion (%) of patients requiring a secondary uterotonic agent and estimated blood loss (EBL) in the first 24 h after surgery.Results: The median oxytocin dose administered was significantly higher in the phenylephrine group than in the control group [6.9 ± 2.5 international standardized units (IU) vs. 5.4 ± 2.4 IU, p = 0.0004]. The number of patients that required a secondary uterotonic agent was significantly higher in the phenylephrine group than in the control group (24.2% vs. 9.1%; p = 0.034). The EBL in the first 24-h postoperatively was similar between the two groups (467 ± 47 ml vs. 392 ± 38 ml; p = 0.22).Conclusions: Prophylactic infusion of phenylephrine used to prevent post-spinal hypotension during CD was associated with a higher dose of oxytocin. This has important clinical implications, as the suboptimal use of oxytocin is associated with an increased risk of postpartum hemorrhage and increased maternal morbidity and mortality. Further studies are now needed to confirm these findings.
Status and Safety Signals of Cephalosporins in Children: A Spontaneous Reporting Database Study
Authors: Cai Yuanxuan , Yang Linhui , Shangguan Xiaofang , Zhao Yuhang , Huang Rui 
Published: October 2021

Introduction: Cephalosporins are widely used in clinical treatment of children, but it is difficult to carry out clinical trials and there is no strong evidence of their safety. Therefore, adverse drug reactions (ADR) of cephalosporins can be a public health problem that deserves attention.Methods: ADR reports collected by the Hubei Adverse Drug Reaction Monitoring Center from 2014 to 2019 were analysed. The safety of Cephalosporins was described by descriptive analysis and three signal mining methods, including the reporting odd ratio (ROR), proportional reporting ratio (PRR), and comprehensive standard method (MHRA).Results: The findings indicated that the age groups of 0–1 and 2–3 years had the highest rates of reporting ADRs. Children aged 0–4 years reported more ADRs, while the proportion of severe ADRs was lower than the average (6.63%). Among the 37 cephalosporins, the severe ADRs of ceftezole, ceftazidime, cefoperazone/sulbactam, cefotaxime, ceftriaxone were reported more and the proportion of severe ADRs was higher. The proportion of severe ADRs of most cephalosporin compound preparations was higher than that of corresponding single components. A total of 99.18% of the cases improved after treatment. There were four deaths whose ADRs were mainly anaphylactic shock, dyspnoea, and anaphylactoid reaction. In signal mining, the three methods produced 206 signals that were the same, and 73 of them were off-label ADRs.Conclusion: ADRs were common but not serious in children aged 0–4 years. And the reported rate of serious ADRs in children aged over 4 years increased with age. ADR reports of ceftezole, ceftazidime, cefoperazone/sulbactam, cefotaxime, ceftriaxone were numerous and serious, and the safety of cephalosporin compound preparations in children was doubtful. Ceftezole may cause off-label ADRs including tremor, face oedema, cyanosis, pallor, rigors, and palpitation. The labeling of ADRs in children in cephalosporin instructions and the record of allergic history need to be improved.
Drug Repurposing for Rare Diseases: A Role for Academia
Authors: van den Berg Sibren , de Visser Saco , Leufkens Hubert G.M. , Hollak Carla E.M. 
Published: October 2021

Background: The European Commission highlights in its Pharmaceutical Strategy the role of academic researchers in drug repurposing, especially in the development of orphan medicinal products (OMPs). This study summarizes the contribution of academia over the last 5 years to registered repurposed OMPs and describes barriers to success, based upon three real world cases.Methods: OMPs granted marketing authorization between January 2016 and December 2020 were reviewed for repurposing and whether the idea originated from academia or industry. Three cases of drug repurposing were selected from different therapeutic areas and stages of development to identify obstacles to success.Results: Thirteen of the 68 OMPs were the result of drug repurposing. In three OMPs, there were two developments such as both a new indication and a modified application. In total, twelve developments originated from academia and four from industry. The three cases showed as barriers to success: lack of outlook for sufficient return of investments (abatacept), lack of regulatory alignment and timing of interaction between healthcare professionals and regulators (etidronate), failure to register an old drug for a fair price, resulting in commercialization as a high priced orphan drug (mexiletine).Conclusion: While the majority of repurposed OMPs originates in academia, a gap exists between healthcare professionals, regulators and industry. Future strategies should aim to overcome these hurdles leading to more patient benefit through sustainable access of repurposed drugs. Potential solutions include improved regulatory and reimbursement knowledge by academia and the right for regulators to integrate new effectiveness data into product labels.
Properties and Sensing Performance of THz Metasurface Based on Carbon Nanotube and Microfluidic Channel
Authors: Wang Yue , Zhang Xiaoju , Zhou Tao , Zhu Yongqiang , Cui Zijian , Zhang Kuang 
Published: October 2021

Carbon-based metamaterials are expected to lead to biological and chemical sensing because of their fast electron transfer rate, good biocompatibility, and high absorption ratios. In this work, we integrate carbon nanotubes metasurface (CM) and microfluidic channel (MC) for a composite terahertz (THz) metasurface (CMMC). The absorption properties and sensing performance of the proposed composite metasurface have been studied. It is observed that the absorption is nearly 71.8% at 0.96 THz and 92.4% at 1.65 THz, respectively. The variation of response with refractive index of the analytes for the proposed CMMC is investigated and it is found that the frequency and intensity of the resonance absorption peak at 0.96 THz f1 decrease obviously with the increase of the refractive index of the analytes. Owing to the coupling of the CM and MC in the microfluidic channel, the interaction between the incident THz wave and analytes has been enhanced, and the frequency and intensity sensitivities has achieved 254 GHz/RIU and 314/RIU, respectively. In addition, the influence of the structural parameters of the proposed CMMC on the absorption characteristics is also studied in detail. The results shown that the absorption properties of the CMMC can be adjusted by changing the structural parameters, which will provide a guideline for design. The proposed CMMC will facilitate the realization of carbon nanotube metamaterials sensing applications, and, when combined with microfluidic channel, will lead to large-area THz biological and chemical sensing.
Mental Health and Work Experiences of Interpreters in the Mental Health Care of Refugees: A Systematic Review
Authors: Geiling Angelika , Knaevelsrud Christine , Böttche Maria , Stammel Nadine 
Published: October 2021

Background:Interpreters often play a crucial role in the health care of refugees. Although interpreters working with refugees are regularly confronted with emotionally stressful content, little is known about their work-related stress and psychological well-being. Primarily qualitative studies indicate increased emotional stress in interpreters, and difficulties in handling the traumatic content from their clients. Additionally, the working conditions of interpreters appear to be demanding, due to low payment and a lack of supervision or adequate preparation.Objective:The presented systematic review aimed to identify and summarise quantitative and qualitative research on the mental health of interpreters in the mental health care of refugees.Method:A systematic search was performed in five databases, and specific interpreting journals were searched. After removal of duplicates, 6,920 hits remained. Eligible studies included quantitative, qualitative, and mixed-methods studies as well as case studies and grey literature. The studies aimed to examine mental health aspects or work experiences of spoken language interpreters in mental health care settings for adult refugees.Results:Altogether, 25 studies were identified, including six quantitative and 19 qualitative studies. Studies were analysed and presented narratively. In the analysis of the qualitative studies, three themes emerged: “Emotions, behaviour, and coping strategies,” “Working in a triad,” and “Working environment.” In the quantitative studies, interpreters showed heightened levels of emotional stress and anxiety, and secondary traumatic stress reactions. In several qualitative studies, interpreters described a devaluing health care system and stressful working conditions with a lack of support structures.Conclusion:Overall, the results indicate a high level of stress among interpreters working with refugees. Quantitative data are sparse, and studies employ heterogeneous assessments in diverse study settings. Therefore, future quantitative research is necessary to consistently investigate interpreters' mental health in different mental health care settings.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42019117948.
Experimental Demonstration of a mmWave Passive Access Point Extender Based on a Binary Reconfigurable Intelligent Surface
Authors: Popov Vladislav , Odit Mikhail , Gros Jean-Baptiste , Lenets Vladimir , Kumagai Akira , Fink Mathias , Enomoto Kotaro , Lerosey Geoffroy 
Published: October 2021

As data rates demands are exploding, 5G will soon rely on mmWaves that offer much higher bandwidths. Yet at these frequencies, attenuation and diffraction of waves require point to point communications with beamforming base stations that are complex and power greedy. Furthermore, since any obstacle at these frequencies completely blocks the waves, the networks must be extremely dense, resulting in dramatic increase of its cost. One way to avoid this problem is to redirect beams coming from base stations at many locations with Reconfigurable Intelligent Surfaces, in order to increase their coverage even in cluttered environments. Here we describe and experimentally demonstrate a binary tunable metasurface operating at 28 GHz, based on standard PCB and off the shelves PIN diodes. We show that it can be used as a Reconfigurable Intelligent Surface that beamforms an incoming plane wave at a given angle to one or several outgoing plane waves at angles reconfigurable in real time. Most importantly we use this 20 cm × 20 cm reconfigurable Intelligent Surface alongside software defined radio and up/down converters at 28 GHz, and demonstrate a wireless link between an emitter and a receiver 10 m away, in a non-line-of-sight configuration, hence proving the validity of the approach.
Pre-operative Prediction of Ki-67 Expression in Various Histological Subtypes of Lung Adenocarcinoma Based on CT Radiomic Features
Authors: Huang Zhiwei , Lyu Mo , Ai Zhu , Chen Yirong , Liang Yuying , Xiang Zhiming 
Published: October 2021

Purpose: The aims of this study were to combine CT images with Ki-67 expression to distinguish various subtypes of lung adenocarcinoma and to pre-operatively predict the Ki-67 expression level based on CT radiomic features.Methods: Data from 215 patients with 237 pathologically proven lung adenocarcinoma lesions who underwent CT and immunohistochemical Ki-67 from January 2019 to April 2021 were retrospectively analyzed. The receiver operating curve (ROC) identified the Ki-67 cut-off value for differentiating subtypes of lung adenocarcinoma. A chi-square test or t-test analyzed the differences in the CT images between the negative expression group (n = 132) and the positive expression group (n = 105), and then the risk factors affecting the expression level of Ki-67 were evaluated. Patients were randomly divided into a training dataset (n = 165) and a validation dataset (n = 72) in a ratio of 7:3. A total of 1,316 quantitative radiomic features were extracted from the Analysis Kinetics (A.K.) software. Radiomic feature selection and radiomic classifier were generated through a least absolute shrinkage and selection operator (LASSO) regression and logistic regression analysis model. The predictive capacity of the radiomic classifiers for the Ki-67 levels was investigated through the ROC curves in the training and testing groups.Results: The cut-off value of the Ki-67 to distinguish subtypes of lung adenocarcinoma was 5%. A comparison of clinical data and imaging features between the two groups showed that histopathological subtypes and air bronchograms could be used as risk factors to evaluate the expression of Ki-67 in lung adenocarcinoma (p = 0.005, p = 0.045, respectively). Through radiomic feature selection, eight top-class features constructed the radiomic model to pre-operatively predict the expression of Ki-67, and the area under the ROC curves of the training group and the testing group were 0.871 and 0.8, respectively.Conclusion: Ki-67 expression level with a cut-off value of 5% could be used to differentiate non-invasive lung adenocarcinomas from invasive lung adenocarcinomas. It is feasible and reliable to pre-operatively predict the expression level of Ki-67 in lung adenocarcinomas based on CT radiomic features, as a non-invasive biomarker to predict the degree of malignant invasion of lung adenocarcinoma, and to evaluate the prognosis of the tumor.
Factors affecting the decision to investigate older adults with potential cancer symptoms: a systematic review
Authors: Jones Daniel , Di Martino Erica , Bradley Stephen H , Essang Blessing , Hemphill Scott , Wright Judy M , Renzi Cristina , Surr Claire , Clegg Andrew , De Wit Niek , Neal Richard 
Published: October 2021

BackgroundOlder age and frailty increase the risk of morbidity and mortality from cancer surgery and intolerance of chemotherapy and radiotherapy. The effect of old age on diagnostic intervals is unknown; however, older adults need a balanced approach to the diagnosis and management of cancer symptoms, considering the benefits of early diagnosis, patient preferences, and the likely prognosis of a cancer.AimTo examine the association between older age and diagnostic processes for cancer, and the specific factors that affect diagnosis.Design and settingA systematic literature review.MethodElectronic databases were searched for studies of patients aged >65 years presenting with cancer symptoms to primary care considering diagnostic decisions. Studies were analysed using thematic synthesis and according to the Synthesis Without Meta-analysis guidelines.ResultsData from 54 studies with 230 729 participants were included. The majority of studies suggested an association between increasing age and prolonged diagnostic interval or deferral of a decision to investigate cancer symptoms. Thematic synthesis highlighted three important factors that resulted in uncertainty in decisions involving older adults: presence of frailty, comorbidities, and cognitive impairment. Data suggested patients wished to be involved in decision making, but the presence of cognitive impairment and the need for additional time within a consultation were significant barriers.ConclusionThis systematic review has highlighted uncertainty in the management of older adults with cancer symptoms. Patients and their family wished to be involved in these decisions. Given the uncertainty regarding optimum management of this group of patients, a shared decision-making approach is important.
ANALISA FAKTOR PENYEBAB RENDAHNYA KINERJA PERAWAT PELAKSANA DI RUMAH SAKIT KOTA MEDAN
Authors: Silalahi Kristina L. , Siregar Patimah Sari 
Published: October 2021

Hospital is a health service with excellent and competitive service demands by its users. The function of the hospital was developed by the guidance of science and technology at its time. Performance appraisal is the most reliable tool for managers to control human resources and productivity and can be used effectively to direct employee behavior to produce nursing services based on high quality and quantity. The purpose of this study was to analyze the factors causing the low performance of nurses in Medan city hospital. This type of research is a quantitative study with a cross-sectional study design. This research was conducted at the Royal Prima Medan Hospital in July. The sample in this study were all nurses who served in the inpatient room. The sampling technique in this study using saturated sampling techniques totaling 159 nurses. Data collection using a questionnaire with the chi-square test. The results showed that the three-dimensional factors of nurse performance had a relationship with the performance of nurses, namely individual factors p = 0.000, psychological factors p = 0.006, and organization p = 0.002. This research concludes that the majority of nurses in the hospital still have low performance. The researcher's suggestion for the hospital is that the hospital pays more attention to the performance of the nurses who work in the inpatient room.
Tai Chi e aspectos neuropsiquiátricos em idosos: revisão sistemática
Authors: Herrmann Flavio , Jacini Wantuir Francisco Siqueira , Galduróz Ruth Ferreira 
Published: October 2021

Introdução. O Tai Chi, uma técnica corpo-mente, tem sido indicada como prática física para idosos devido a suas características singulares de execução, como lentidão e concentração. Objetivo. O objetivo do presente estudo foi avaliar as contribuições do Tai Chi em aspectos neuropsiquiátricos, por meio de uma revisão sistemática da Literatura. Método. Para tanto, foram utilizadas diferentes bases de dados, sendo elas:  LILACS, Pubmed, Psycinfo, Scielo, Embase e Science Direct. Os artigos foram selecionados de janeiro de 2020 a fevereiro de 2021, considerando artigos publicados nos últimos 10 anos com idosos. Resultados. Um total de 20 estudos foram selecionados. Conclusão. O Tai Chi pode ter efeitos benéficos como melhora no equilíbrio, qualidade do sono, diminuição do número de quedas, memória, qualidade de vida, diminuição do nível de estresse, etc. A análise da pontuação dos artigos na escala PEDro revelou limitações metodológicas, sugerindo a importância de novos estudos com maior controle de fatores de interferência em aspectos neuropsiquiátricos.
The Image of a Soviet Woman as Depicted by Mass Media in the 1950s–1960s and Engraved in Social Memory (regional aspects)
Authors: Богдашина И.В. 
Published: October 2021

В статье раскрываются репрезентативные формы образа советской женщины на материалах нестоличного города. Возможность привлечения сведений радиопередач и эго-документов как малоизученных форм женской репрезентации позволяет автору выявить и сравнить идеализированный и реально существующий образ советской женщины 1950–1960-х годов. Средства массовой информации формировали идеологически одобренный женский портрет, являясь транслятором допустимых и запрещенных норм, которые жительницы города старались соблюдать. Превалирующий образ «женщины-работницы», активно вовлеченной в семейную и общественную жизнь, был недосягаем для «обычных» советских женщин. Несмотря на это, многие из них стремились занять лидирующие позиции хотя бы в одной из сфер. Несовпадение идеализированного и реально существующего женских образов влекло за собой критику со стороны власти и общественности. Опасение быть осужденной и желание обличать накладывали на женщин определенные каноны поведения, которые исподволь внедрялись массовой культурой.
The article investigates the image of a Soviet woman as portrayed by provincial mass media. The article analyzes such underrated sources of reliable information as egodocuments and radio performances, which enables the author to compare the idealized image of a Soviet woman and the real image of a Soviet woman of the 1950s–1960s. Mass media created an ideologically “proper” image
of a female worker who was actively involved in family and social life. Despite the fact that many “ordinary” Soviet women did their best to fully realize their potential in at least one sphere of life, they had no means to conform to the ideal image broadcast by the media. Due to the discrepancy between
the ideal and realistic images, Soviet women often fell victim to social and political criticism. Gnawed
by the fear of censure and the desire to condemn others, women were forced to acquire certain behavior patterns dictated by mass culture.