bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebral Macro- and Microcirculation during Ephedrine versus Phenylephrine Treatment in Anesthetized Brain Tumor Patients: A Randomized Clinical Trial Using Magnetic Resonance Imaging
Authors: Koch Klaus U. , Mikkelsen Irene K. , Espelund Ulrick S. , Angleys Hugo , Tietze Anna , Oettingen Gorm V. , Juul Niels , Østergaard Leif , Rasmussen Mads 
Published: August 2021

Background
This study compared ephedrine versus phenylephrine treatment on cerebral macro- and microcirculation, measured by cerebral blood flow, and capillary transit time heterogeneity, in anesthetized brain tumor patients. The hypothesis was that capillary transit time heterogeneity in selected brain regions is greater during phenylephrine than during ephedrine, thus reducing cerebral oxygen tension.

Methods
In this single-center, double-blinded, randomized clinical trial, 24 anesthetized brain tumor patients were randomly assigned to ephedrine or phenylephrine. Magnetic resonance imaging of peritumoral and contralateral hemispheres was performed before and during vasopressor infusion. The primary endpoint was between-group difference in capillary transit time heterogeneity. Secondary endpoints included changes in cerebral blood flow, estimated oxygen extraction fraction, and brain tissue oxygen tension.

Results
Data from 20 patients showed that mean (± SD) capillary transit time heterogeneity in the contralateral hemisphere increased during phenylephrine from 3.0 ± 0.5 to 3.2 ± 0.7 s and decreased during ephedrine from 3.1 ± 0.8 to 2.7 ± 0.7 s (difference phenylephrine versus difference ephedrine [95% CI], −0.6 [−0.9 to −0.2] s; P = 0.004). In the peritumoral region, the mean capillary transit time heterogeneity increased during phenylephrine from 4.1 ± 0.7 to 4.3 ± 0.8 s and decreased during ephedrine from 3.5 ± 0.9 to 3.3 ± 0.9 s (difference phenylephrine versus difference ephedrine [95%CI], −0.4[−0.9 to 0.1] s; P = 0.130). Cerebral blood flow (contralateral hemisphere ratio difference [95% CI], 0.3 [0.06 to 0.54]; P = 0.018; and peritumoral ratio difference [95% CI], 0.3 [0.06 to 0.54; P = 0.018) and estimated brain tissue oxygen tension (contralateral hemisphere ratio difference [95% CI], 0.34 [0.09 to 0.59]; P = 0.001; and peritumoral ratio difference [95% CI], 0.33 [0.09 to 0.57]; P = 0.010) were greater during ephedrine than phenylephrine in both regions.

Conclusions
Phenylephrine caused microcirculation in contralateral tissue, measured by the change in capillary transit time heterogeneity, to deteriorate compared with ephedrine, despite reaching similar mean arterial pressure endpoints. Ephedrine improved cerebral blood flow and tissue oxygenation in both brain regions and may be superior to phenylephrine in improving cerebral macro- and microscopic hemodynamics and oxygenation.

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Development of a compact alkynyl-enrichable crosslinker for in-depth in-vivo crosslinking analysis
Authors: Gao Hang , Zhao Lili , Zhao Baofeng , Gong Zhou , Zhao Qun , Zhang Lihua 
Published: July 2021

AbstractChemical crosslinking coupled with mass spectrometry (CXMS) has emerged as a powerfμl technique to capture the dynamic information of protein complexes with high sensitivity, throughput and sample universality. To advance the study of in-vivo protein structures and protein-protein interactions on the large scale, a new alkynyl-enrichable crosslinker was developed with high efficiency of membrane penetration, reactivity and enrichment. The crosslinker was successfully used for in-vivo crosslinking of intact human cells, resμlting in 6820 non-redundant crosslinks identified at a false discovery rate (FDR) of 1% using pLink 2.0, which 4898 (71.8%) of the cross-links were assigned as intraprotein and 1922 (28.2%) were interprotein links. To our knowledge, this is also the first time to realize the in-vivo crosslinking with a non-cleavable crosslinker for homo species cells.
Transcriptomic analysis of pathways associated with αv integrin-related non-canonical autophagy in human B cells
Authors: Muir Virginia , Sagadiev Sara , Suchland Emmaline , Meitlis Iana , Giltiay Natalia , Tam Jenny M. , Garner Ethan C. , Wivagg Carl N , Shows Donna , James Richard G. , Lacy-Hulbert Adam , Acharya Mridu 
Published: August 2021

AbstractAutophagy proteins have been linked with development of immune-mediated diseases including lupus, but the mechanisms for this are unclear. We have previously shown that non-canonical autophagy induced by αv-integrins regulates B cell activation by viral and self-antigens in mice. Here we investigated the involvement of this pathway in B cells from human tissue. Our data revealed that autophagy is specifically induced in germinal-center and memory B cell sub-populations from human tonsil and spleen. Transcriptomic analysis showed that induction of autophagy is related to unique aspects of activated B cells such as mitochondrial metabolism. To understand the function of non-canonical autophagy in B cells, we used CRISPR-mediated knockdown of autophagy genes. Integrating data from primary B cells and knockout cells we found that αv-integrin-related non-canonical autophagy limits activation of specific pathways while promoting others. These data provide new mechanistic links for autophagy and immune dysregulation in diseases such as lupus.
Inhibition of the H3K27 demethylase UTX enhances the epigenetic silencing of HIV proviruses and induces HIV-1 DNA hypermethylation but fails to permanently block HIV reactivation
Authors: Nguyen Kien , Dobrowolski Curtis , Shukla Meenakshi , Cho Won-Kyung , Karn Jonathan 
Published: August 2021

AbstractOne strategy for a functional cure of HIV-1 is “block and lock”, which seeks to permanently suppress the rebound of quiescent HIV-1 by epigenetic silencing. For the HIV LTR, both histone 3 lysine 27 tri-methylation (H3K27me3) and DNA methylation are associated with viral suppression, while H3K4 tri-methylation (H3K4me3) is correlated with viral expression. However, H3K27me3 is readily reversed upon activation of T-cells through the T-cell receptor. To suppress latent HIV-1 in a stable fashion, we depleted the expression or inhibited the activity of UTX/KDM6A, the major H3K27 demethylase, and investigated its impact on latent HIV-1 reactivation in T cells. Inhibition of UTX dramatically enhanced H3K27me3 levels at the HIV LTR and were associated with increased DNA methylation. In latently infected cells from patients, GSK-J4, which is a potent dual inhibitor of the H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, effectively suppressed the reactivation of latent HIV-1 and induced DNA methylation at specific sites in the 5’LTR of latent HIV-1 by the enhanced recruitment of DNMT3A to HIV-1. Nonetheless, suppression of HIV-1 through epigenetic silencing required the continued treatment with GSK-J4 and was rapidly reversed after removal of the drug. Thus, epigenetic silencing by itself appears to be insufficient to permanently silence HIV-1 proviral transcription.Author SummaryThe “block and lock” strategy for a functional HIV-1 cure is based on the premise that permanent inactivation of the HIV-1 can be achieved by epigenetic silencing of the proviral DNA. For cellular genes, long-term silencing is achieved during cell differentiation by the induction of specific epigenetic modifications involving histone and DNA methylation. During HIV-1 silencing, histone methylation and DNA methylation are observed, but both sets of modifications can be reversed upon activation of T-cells through the T-cell receptor or potent latency reversing agents. In an attempt to enhance silencing of HIV-1 transcription, we used an inhibitor of H3K27 demethylases to increase H3K27 methylation. This in turn led to enhanced DNA methylation of HIV-1. Unfortunately, although the treatment effectively silenced HIV-1 and prevented viral reactivation, the silencing effects were short-lived and quickly reversed after removal of the drug.
Protection of railway infrastructure objects against electrical corrosion
Authors: Trykoz Liudmyla , Kamchatnaya Svetlana , Borodin Dmytro , Atynian Armen , Tkachenko Roman 
Published: August 2021

Purpose
The purpose of this paper is to develop a technological method of protection against electrical corrosion. One more way to protect the objects is to prevent the electrical current from getting to them. For example, railway objects are surrounded with a material with raised electrical resistance.

Design/methodology/approach
The railway infrastructure objects (foundations, contact-line supports, reinforced concrete sub-bases, bridge structures, pipelines of engineering networks, supports of passenger platforms and pedestrian bridges, concrete plinth walls of station buildings) are subjected to destruction due to the action of electrical current. One of destruction factors is a corrosion of the concrete constructions which is caused by the leakage current action.

Findings
Leakage currents and stray currents bypass the structure of supports of high passenger platforms or pipes of engineering networks. These currents spread by the line with the least resistance outside of the structures.

Research limitations/implications
Electrical leakage current from the rails gets into such structures through sleepers, ballast and soil and leads to accelerated corrosion leaching of concrete.

Practical implications
The constructions are protected against the destructive effect of electrical corrosion on the metal or concrete of the structure. This scheme is suitable for the construction and reconstruction of railway structures which operate on electrified sections of railways.

Originality/value
Schemes of technological solution are proposed for protection of foundations, supports of high passenger platforms, pipelines of engineering networks, etc. For this, the arrangement of soil-contained screens with big electrical resistance is suggested.
Rethinking free skilled labour migration policies in CLMV countries: a qualitative systematic review
Authors: Daovisan Hanvedes , Phukrongpet Pimporn , Chamaratana Thanapauge 
Published: August 2021

PurposeThere is an ongoing debate in the ASEAN Economic Community (AEC) Blueprint 2015 concerning the skilled labour migration policy regimes. This review aims to systematise the free flow of skilled labour migration policies in Cambodia, Lao PDR, Myanmar and Vietnam (CLMV) countries.Design/methodology/approachThis review utilised a qualitative systematic in peer-reviewed journals for the period 2015–2019. The initial search identified 28,874 articles. Of those articles, 10,612 articles were screened, 738 articles were checked, 150 articles were selected and 18 articles met the criteria. Data were analysed using thematic synthesis (e.g. coding, categorisation, synthesis and summarisation).FindingsThe review suggested that free movement from CLMV countries is the cause of the mass exodus of unskilled migration to high-income countries. The review found that the free flow of migration policy in the AEC Blueprint 2015 is associated with illegal, unauthorised and unskilled workers in the host country.Research limitations/implicationsA systematic review is qualitative in nature, in which the relevant existing literature lacks some empirical studies, and the results must be generalisable.Practical implicationsThe current systematic review provides a visual diagram for practical implications to isolate undocumented, illegal, unpermitted and unskilled migrant workers and further reduce the mass exodus of migration from CLMV countries.Originality/valueTo the authors' knowledge, this is the first review to extend the literature to the macro-level determinants of free flow of skilled labour migration policies in CLMV countries. The present review seeks to inform the policy responses of moving freely between sending and receiving countries.
Principles-based accounting standards and the timeliness of annual reports: evidence from China
Authors: Song Fei , Zhou Jianan 
Published: August 2021

PurposeThis paper addresses the role of principles-based accounting standards as a potential mechanism for reducing firms' time delay of annual reporting disclosure while improving the timeliness of accounting information. The paper also contributes to the existing literature by addressing the mediating effects of the financial reporting complexity and the audit workload on the link between principles-based accounting standards and the time delay of annual reporting disclosure.Design/methodology/approachThe focus is placed on an unbalanced panel of 20,943 samples over the period of 2007–2017.FindingsThe results show that the more principles-based the accounting standards are, the lower the time delay of annual reporting disclosure is, and the timelier the disclosure of accounting information is. The relationship between the two is more significant especially in the first two months after the end of the fiscal year. The findings are all robust after controlling for a series of sensitivity checks and endogenous concerns. From the mediating effect results, the authors find that principles-based accounting standards decrease the financial reporting complexity and the audit workload which in turn can help lower time delay of annual reporting disclosure. In addition, the negative effect of principles-based accounting standards on the time delay of annual reporting disclosure is more significant in the case that the company has “good news” including with no losses and receiving the standard auditing opinions. The results confirm the law of “good news announces early, bad news announces late.” Furthermore, the moderating effect results show that the higher the economic policy uncertainty index and the legal environment index, the lower the benefit of principles-based accounting standards to the timeliness of annual reports. The results of the economic consequences of timeliness suggest that the timely disclosure of accounting reporting will bring greater market reaction and contain more information, and the information of companies that disclose annual reports timely are more transparent.Originality/valueThis paper studies the impact of accounting standards on the timeliness of annual report disclosure, which enriches the literature in the field of macro policies and micro-enterprise behaviors.
Exploring the antecedents and consequences of the coffee quality of Starbucks: a case study
Authors: Lee Won Seok , Jung Jiwoo , Moon Joonho 
Published: August 2021

PurposeThe purpose of this study is to analyze the influence of coffee quality on brand preference and loyalty using Starbucks as a study subject. The determinants of coffee food healthiness are also investigated.Design/methodology/approachFood quality measures are composed of healthiness, taste, customization, price fairness and convenience. Hygiene and nutrition disclosure were examined as determinants of food healthiness. The highlighted food quality attributes were brand love and brand loyalty. Data were collected using Amazon Mechanical Turk. A total of 431 observations were used for data analysis. A structural equation model was conducted for hypotheses testing.FindingsThe results revealed that healthiness is positively associated with hygiene and nutrition disclosure. Brand love is also significantly influenced by healthiness, taste, customization and price fairness. Moreover, taste and price fairness appeared to be essential determinants of Starbucks brand loyalty.Originality/valueThis study scrutinized food quality in the domain of coffee business, and presented implications for the business. Data collected in this study contributed to the literature by revealing quality attributes of coffee and its determinants and also showing the significant relationship between coffee food quality, brand love and brand loyalty.
An ultra-low noise pseudomorphic high electron mobility transistor (pHEMT)-based low noise amplifier using low temperature co-fire ceramic (LTCC) technique
Authors: Bhuvaneshwari Subburaman , Kanthamani Sundharajan 
Published: August 2021

Purpose
This study aims to present two stage pseudomorphic high electron mobility transistor-based low noise amplifier (LNA) designed using low temperature co-fire ceramic (LTCC) technique for ultra-high frequency (UHF) band. The LNA operates in the frequency range of (400∼500) MHz which is suitable for wireless communication applications.

Design/methodology/approach
This LNA uses resistive capacitive (RC) feedback in the first stage to have wide bandwidth and interstage network for gain enhancement. By using external RC feedback, stability is improved and noise matching in the input stage is isolated by decoupling inductor. The excellent performance parameters including gain, noise figure (NF), wideband and linearity are attained without affecting the power consumption, compactness and cost of the proposed design.

Findings
Simulation is carried out using advanced design software and the result shows that gain of 33.7 dB, NF 0.416 dB and 1 dB compression point (P1dB) of 18.59 dBm are achieved with a supply voltage of 2.5 V. The return loss of input and output are −19.3 dB and −10.5 dB, respectively. From the above aforementioned parameters, it is confirmed that the proposed LNA is a promising candidate for receivers where high gain and very low NF are always demandable with good linearity for applications operating in the UHF band.

Originality/value
The innovation of the proposed LNA is that the concurrent attainment of high gain, low NF, wideband, optimum input matching, good stability by RC feedback and interstage network using LTCC technique to achieve robustness, low cost and compactness to prove the applicability of design for wireless applications.
Value co-creation and co-destruction in the first cashless society in Colombia – a middle range theory approach
Authors: van Klyton Aaron , Tavera-Mesias Juan-Fernando , Castaño-Muñoz Wilson 
Published: August 2021

PurposeThe research examines the simultaneous processes of value co-creation and value co-destruction in the implementation of a mobile banking application in rural Colombia. Rural communities experience digital and financial deficits and often become the object of technology-based initiatives. In the town, vulnerable female heads of household received a government subsidy through a mobile app, becoming an experimental group for this government–private bank collaboration. In an effort to create the first cashless society in Colombia, the bank engaged the entire town and local government to create a service ecosystem, constituted by operant resources.Design/methodology/approachThis study uses a qualitative, ethnographic approach to investigate the experiences of stakeholders in engaging with a mobile banking app. The empirical data is drawn from 34 interviews, representing different layers of this service ecosystem. The study identified and analysed actor engagement behaviours that occurred in the micro-, meso-, macro- and meta-layers of this ecosystem that shaped the perception and usage of mobile payments and digital money for rural consumers.FindingsThe study found that simultaneous manifestations of the co-creation and co-destruction of value present in different layers ultimately diminished the value proposition for this digital money system. We shed light on how actor engagement transitions across different layers of the ecosystem and that negative interactions in the meta-layer of the ecosystem can affect perceptions of value in the micro-layer.Originality/valueThis study has contributed to the service literature by integrating epistemological cultural theory into value co-creation and co-destruction construct. In doing so, we provide a broader context for understanding how actor engagement can negatively impact on the value creation process and offer a meaningful contribution to the development of midrange theory of the value creation process.
Accumulating capital through social media: the transformative power of underrepresented fashion consumers
Authors: Cavusoglu Lena , Atik Deniz 
Published: August 2021

Purpose
Previous research in sociology, psychology and fashion studies has investigated the concept of diversity in the fashion context, but the topic remains largely understudied within the realm of consumer research. This study aims to examine the reactions of underrepresented women to the fashion industry’s lack of diversity.

Design/methodology/approach
A total of 38 semi-structured in-depth interviews were conducted among a sample of female consumers who were diverse with respect to racial and ethnic background, socioeconomic class, religion, sexual orientation, age, body type and physical appearance.

Findings
Using Bourdieu’s forms of capital – social, cultural, economic and symbolic – the findings shed light on the process of virtual community formation on social media in response to the lack of diversity in fashion; reveal fashion consumers’ power to enact institution-level change, compelling the industry to become more diverse and inclusive; demonstrate the outcomes of capital accumulation and illustrate how all forms of capital are produced by and reproduce each other.

Originality/value
This study proposes a new outcome of capital accumulation on virtual communities, termed “transformative value,” in addition to the social and information values identified in earlier scholarship.
Impact of COVID-19 on financial institutions: navigating the global emerging patterns of financial crime
Authors: Wronka Christoph 
Published: August 2021

PurposeThe current COVID-19 pandemic has already proven to be one of the world’s deadliest crises in modern history with far-reaching impacts on different sectors of the global economy. The financial sector is among the most widely affected by the economic crisis occasioned by the COVID-19 pandemic. One of the most notable effects is related to financial crime. It is against this backdrop that the present study aimed to examine the impact of COVID-19 on financial institutions with the main focus being on financial crimeDesign/methodology/approachIts twofold objectives were to critically examine the global emerging patterns of financial crime and their association with the COVID-19 pandemic; and to investigate how financial institutions across the world have been responding to, managing, and dealing with the emerging patterns of financial crime brought about by (or linked to) the COVID-19 pandemic.FindingsIt was found out that as the pandemic ravages the world and pushes people and businesses to the very limits of their endurance, many financial sector stakeholders and players are responding in ways that put the entire financial sector and all its stakeholders at great risk. Specifically, COVID-19 pandemic has led to the emergence of new patterns of financial crime that were either unheard of or were not as rampant in the past.Originality/valueBoth the descriptive and correlation analyses produced by this study provide new insights into the impact of COVID-19 on financial institutions with a main focus on financial crime.