bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthostatic intolerance syndromes after hematopoietic cell transplantation: clinical characteristics and therapeutic interventions in a single-center experience
Authors: Vecchié Alessandra , Thomas Georgia , Bressi Edoardo , Bonaventura Aldo , Canada Justin M. , Chuquin David , Kadariya Dinesh , Piracha Usman , Endicott Delia , Markley Roshanak , Toor Amir , Hess Michael , Abbate Antonio 
Published: November 2021

Abstract
Background
Hematopoietic cell transplantation (HCT) is an established and potentially curative therapeutic option for hematologic cancers. HCT survivors are at risk of developing long-term complications impacting on morbidity and mortality. Orthostatic hypotension (OH) and postural tachycardia syndrome (POTS) have been anecdotally described after HCT. However, the incidence and clinical characteristics of patients with OH and POTS after HCT has not been well defined.

Methods
This retrospective study included 132 patients who had HCT between March 2011 and July 2018 and were referred to Cardio-oncology clinic. Patients were screened for OH and POTS. Using logistic regression analysis we evaluated the association between clinical factors and the incidence of OH and POTS.

Results
Median age was 58 (47–63) years, 87 (66%) patients were male, 95 (72%) were Caucasian. OH was diagnosed in 30 (23%) subjects and POTS in 12 (9%) after the HCT. No significant differences in demographic characteristics were found when comparing patients with and without OH or POTS. The two groups did not differ for cardiovascular diseases prevalence nor for the prior use of antihypertensive drugs. Previous radiotherapy and treatment with specific chemotherapy drugs were found to be associated with the incidence of OH or POTS, but none of the factors maintained the significance in the multivariate model. Pharmacological therapy was required in 38 (91%) cases, including a b-adrenergic blocker (n = 24, 57%), midodrine (n = 24, 57%) and fludrocortisone (n = 7, 18%).

Conclusion
Orthostatic intolerance syndromes are commonly diagnosed in patients referred to the cardiologist after HCT, involving approximately 1/3 of patients and requiring pharmacological therapy to cope with symptoms in the majority of cases. Risk factors specific to this population are identified but cannot fully explain the incidence of POTS and OH after HCT.
Knowledge, perceptions, and clinical experience regarding Molar-Incisor Hypomineralization among a group of general dental practitioners, pediatric dentists, and other dental specialists in Egypt: a cross-sectional study
Authors: Yehia Alaa Mohammed , Abdelaziz Amr M. , Badran Amira 
Published: November 2021

Abstract
Background
Molar-Incisor Hypomineralization (MIH) is a prevalent clinical condition which is associated with a high burden of disease. The present study aimed to assess and compare the knowledge, perceptions, and clinical experience of general dental practitioners (GDPs), pediatric dentists (PDs), and other dental specialists (DSs) in Egypt about MIH.

Methods
Online and paper-based survey administration methods were used to collect the responses from Egyptian dentists regarding their knowledge, and perceptions about MIH. The survey tool focused on participants’ socio-demographics, clinical experience, perceptions, clinical management, and preferences for further training. The level of knowledge regarding MIH was compared among the three groups. Data analysis utilized Chi-square and one-way ANOVA followed by Tukey’s post hoc test using SPSS® Statistics Version 26.

Results
The majority of respondents had observed MIH in their practice (86%). The participants who had a postgraduate degree had a significantly higher knowledge score value (51.01 ± 5.74) than GDPs (43.05 ± 7.04) (p < 0.001). PDs (51.13 ± 4.76) had a significantly higher knowledge score value than other DSs (50.91 ± 6.46) (p < 0.001).

Conclusions
Dissemination of evidence on MIH to dental practitioners especially to GDPs is highly needed to assure confidence in MIH diagnosis at an early stage when it can be best managed.
TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients
Authors: Peralta Estela Morales , Rosales Yaíma Zúñiga , Mesa Teresa Collazo , González Elvia Nelmi Santos , Pérez Yadira Hernández , de los Ángeles González Torres María , Balbuena Hilda Roblejo , Teruel Beatriz Marcheco 
Published: November 2021

Abstract
Purpose
To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients.

Methods
TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19.

Results
There was a greater possibility of presenting symptomatic forms [OR = 2.081, 95% CI: 0.243–17.842], even severe [OR = 1.200, 95% CI: 0.217–6.638], related to the tt genotype.

Conclusion
There are signs of association between the risk of developing COVID-19 and the genotypes of the TaqI polymorphism of the VDR gene in the studied Cuban patients.
Translation-dependent mRNA localization to Caenorhabditis elegans adherens junctions
Authors: Tocchini Cristina , Rohner Michèle , Guerard Laurent , Ray Poulomi , Von Stetina Stephen E. , Mango Susan E. 
Published: November 2021

ABSTRACT
mRNA localization is an evolutionarily widespread phenomenon that can facilitate subcellular protein targeting. Extensive work has focused on mRNA targeting through ‘zip-codes’ within untranslated regions (UTRs), whereas much less is known about translation-dependent cues. Here, we examine mRNA localization in Caenorhabditis elegans embryonic epithelia. From an smFISH-based survey, we identified mRNAs associated with the cell membrane or cortex, and with apical junctions in a stage- and cell type-specific manner. Mutational analyses for one of these transcripts, dlg-1/discs large, revealed that it relied on a translation-dependent process and did not require its 5′ or 3′ UTRs. We suggest a model in which dlg-1 transcripts are co-translationally localized with the nascent protein: first the translating complex goes to the cell membrane using sequences located at the C-terminal/3′ end, and then apically using N-terminal/5′ sequences. These studies identify a translation-based process for mRNA localization within developing epithelia and determine the necessary cis-acting sequences for dlg-1 mRNA targeting.
Co-feeding of vacuum gas oil and pinewood-derived hydrogenated pyrolysis oils in a fluid catalytic cracking pilot plant to generate olefins and gasoline
Authors: Buechele Marco , Lutz Helene , Knaus Florian , Reichhold Alexander , Venderbosch Robbie , Vollnhofer Wolfgang 
Published: November 2021

Background: The Waste2Road project exploits new sustainable pathways to generate biogenic fuels from waste materials, deploying existing industrial scale processes. One such pathway is through pyrolysis of wood wastes. Methods: The hereby generated pyrolysis liquids were hydrogenated prior to co-feeding in a fluid catalytic cracking (FCC) pilot plant. So-called stabilized pyrolysis oil (SPO) underwent one mild hydrogenation step (max. 200 °C) whereas the stabilized and deoxygenated pyrolysis oil (SDPO) was produced in two steps, a mild one (maximum 250 °C) prior to a more severe process step (350 °C). These liquids were co-fed with vacuum gas oil (VGO) in an FCC pilot plant under varying riser temperatures (530 and 550 °C). The results of the produced hydrocarbon gases and gasoline were benchmarked to feeding pure VGO. Results: It was proven that co-feeding up to 10 wt% SPO and SDPO is feasible. However, further experiments are recommended for SPO due to operational instabilities originating from pipe clogging. SPO led to an increase in the hydrocarbon gas production from 45.0 to 46.3 wt% at 550 °C and no significant changes at 530 °C. SDPO led to a rise in gasoline yield at both riser temperatures. The highest amount of gasoline was produced when SDPO was co-fed at a 530 °C riser temperature, with values around 44.8 wt%. Co-feeding hydrogenated pyrolysis oils did not lead to a rise in sulfur content in the gasoline fractions. The highest values were around 18 ppm sulfur content. Instead, higher amounts of nitrogen were observed in the gasoline. Conclusions: SPO and SDPO proved to be valuable co-refining options which led to no significant decreases in product quality. Further experiments are encouraged to determine the maximum possible co-feeding rates. As a first step, 20-30 wt% for SPO are recommended, whereas for SDPO 100 wt% could be achievable.
Testing the Role of Contextual Deliberation in the Compromise Effect
Authors: Guo Liang 
Published: November 2021

Many phenomena of preference construction demonstrate a violation of the rationality premise in classical economic theories. One of the most well-known examples of preference construction is the compromise effect. This puzzling anomaly can be rationalized by contextual deliberation (i.e., endogenous information retrieval/acquisition that can partially resolve utility uncertainty before choice). In this research, we investigate the empirical validity of this explanation by performing falsification tests for its necessary predictions and identifying it from other potential accounts. We conduct five experiments with more than 1,000 participants and show that the compromise effect can be positively mediated by response time and cannot be eliminated by context information, but it can be moderated by manipulating the level of deliberation (i.e., time constraint, preference articulation, task order). These findings are consistent with the predictions of the theory of contextual deliberation. We also show that, on average, contextual deliberation (as proxied by response time) can uniquely account for about half of the total compromise effect. This paper was accepted by Yan Chen, behavioral economics and decision analysis.
Motion picture of magnified light pulse propagation with extending recordable time of digital light-in-flight holography
Authors: Inoue Tomoyoshi , Aoyama Takamasa , Sawashima Yu , Nishio Kenzo , Kubota Toshihiro , Awatsuji Yasuhiro 
Published: November 2021

We experimentally demonstrate a motion picture imaging technique that can record a magnified image of light pulse propagation with extending the recordable time of digital light-in-flight recording by holography. We constructed an optical system that achieves a recordable time extension and an observation of a magnified image of light pulse propagation. As a result, we experimentally succeeded in recording light pulse propagation with a 7.45 magnification rate with extending the recordable time. The recordable time of the motion picture was 714 fs, which is twice that of the conventional one.
2  μm optical frequency comb generation via optical parametric oscillation from a lithium niobate optical superlattice box resonator
Authors: Wang Xiaohan , Jia Kunpeng , Chen Mengwen , Cheng Shanshan , Ni Xin , Guo Jian , Li Yihao , Liu Huaying , Hao Liyun , Ning Jian , Zhao Gang , Lv Xinjie , Huang Shu-Wei , Xie Zhenda , Zhu Shi-Ning 
Published: November 2021

Optical parametric oscillators (OPOs) can downconvert the pump laser to longer wavelengths with octave separation via

χ

(
2
)

, which is widely used for laser wavelength extension including mid-infrared (MIR) generation. Such a process can be integrated in monolithic resonators, being compact and low in threshold. In this work, we show that the monolithic

χ

(
2
)

mini-OPO can also be used for optical frequency comb generation around 2096 nm and enters the boundary of MIR range. A new geometry called an optical superlattice box resonator is developed for this realization with near-material-limited quality factor of

4.0
×

10

7

. Only a continuous-wave near-infrared pump laser is required, with OPO threshold of 80 mW and output power up to 340 mW. Revival temporal profiles are measured at a detectable repetition frequency of 1.426 GHz, and narrow beat note linewidth of less than 10 Hz shows high comb coherence. These results are in good agreement with our simulation for a stable comb generation. Such an OPO-based comb source is useful for carbon dioxide sensing or the mine prospect applications and can be generalized to longer MIR wavelengths for general gas spectroscopy.
Hybrid APC in Combination With Resection for the Endoscopic Treatment of Neoplastic Barrett's Esophagus: A Prospective, Multicenter Study
Authors: Knabe Mate , Beyna Torsten , Rösch Thomas , Bergman Jacques , Manner Hendrik , May Andrea , Schachschal Guido , Neuhaus Horst , Kandler Jennis , Weusten Bas , Pech Oliver , Faiss Siegbert , Anders Mario , Vieth Michael , Sehner Susanne , Bisschops Raf , Bhandari Pradeep , Ell Christian , Ehlken Hanno 
Published: November 2021

INTRODUCTION:
The current therapy of neoplastic Barrett's esophagus (BE) consists of endoscopic resection plus ablation, with radiofrequency ablation as the best studied technique. This prospective trial assesses a potential alternative, namely hybrid argon plasma ablation.

METHODS:
Consecutive patients with neoplastic BE undergoing ablation after curative endoscopic resection (89.6%) or primarily were included into this prospective trial in 9 European centers. Up to 5 ablation sessions were allowed for complete eradication of BE (initial complete eradication of intestinal metaplasia [CE-IM]), by definition including BE-associated neoplasia, documented by 1 negative endoscopy with biopsies. The main outcome was the rate of initial CE-IM in intention-to-treat (ITT) and per-protocol (PP) samples at 2 years. The secondary end points were the rate of recurrence-free cases (sustained CE-IM) documented by negative follow-up endoscopies with biopsies and immediate/delayed adverse events.

RESULTS:
One hundred fifty-four patients (133 men and 21 women, mean age 64 years) received a mean of 1.2 resection and 2.7 ablation sessions (range 1–5). Initial CE-IM was achieved in 87.2% of 148 cases in the PP analysis (ITT 88.4%); initial BE-associated neoplasia was 98.0%. On 2-year follow-up of the 129 successfully treated cases, 70.8% (PP) or 65.9% (ITT) showed sustained CE-IM; recurrences were mostly endoscopy-negative biopsy-proven BE epithelium and neoplasia in 3 cases. Adverse events were seen in 6.1%.

DISCUSSION:
Eradication and recurrence rates of Barrett's intestinal metaplasia and neoplasia by means of hybrid argon plasma coagulation at 2 years seem to be within expected ranges. Final evidence in comparison to radiofrequency ablation can only be provided by a randomized comparative trial.
Policies and practices in the field of laboratory hematology in Croatia – a current overview and call for improvement
Authors: Biljak Vanja Radišić , Lapić Ivana , Vidranski Valentina , Herceg Ivona , Tomić Franciska , Šimac Brankica , Horvat Martina , Čičak Helena , Vuljanić Dora , Dorotić Adrijana , Nikler Ana 
Published: November 2021

Abstract

Objectives
In 2019 The Croatian Working Group for Laboratory Hematology, on behalf of the Croatian Society of Medical Biochemistry and Laboratory Medicine, wanted to explore the background in field of laboratory hematology routine practice among Croatian laboratories in order to develop future strategies for producing national recommendations, if needed.

Methods
During April and May 2019, a comprehensive survey covering all main parts of the total testing process within the field of laboratory hematology among Croatian medical laboratories was conducted. The survey comprised 49 inquiries. Data was collected using Survey Monkey (Palo Alto, CA, USA). All collected data was anonymized.

Results
The response rate was 72%. There is still a substantial number of laboratories that have only three-part differential hematology analyzers (9%). Furthermore, a very high number of laboratories did not perform analyzer verification prior to implementation into routine work (31%). Out of those who have verified their analyzers, a diversity of guidelines and recommendations were used. Nearly 10% of the laboratories do not have a defined policy regarding specimen rejection. The majority of the participants perform internal quality control daily (83%), however, only 51% of respondents evaluate the agreement between different hematology analyzers on daily basis. Although more than 90% of Croatian laboratories have a defined policy regarding specimen rejection, only 61% of respondents continuously monitor quality indicators in routine practice.

Conclusions
The survey revealed substantial differences in all aspects of laboratory hematology practices among Croatian medical laboratories, indicating the need for universal recommendations at the national level.
The association of cytochrome 7A1 and ATP-binding cassette G8 genotypes with type 2 diabetes among Jordanian patients
Authors: Abed Eyada , Jarrar Yazun , Alhawari Hussam , Abdullah Sarah , Zihlif Malek 
Published: November 2021

Abstract

Objectives
Increased cholesterol levels were found to be associated with diabetes mellitus type II (DM2). The cholesterol is metabolized by cytochrome 7A1 (CYP7A1) and transported in the intestine by ATP-binding cassette G8 (ABCG8). Genetic variants in CYP7A1 and ABCG8 genes can affect the cholesterol levels. The aim of this study is to compare the frequency of CYP7A1 rs3808607 and ABCG8 rs11887534 and rs4148217 genotypes between healthy and DM2 subjects from Jordanian population.

Methods
A total of 117 DM2 patients and 100 healthy controls, of Jordanian Arabic origin, were genotyped for CYP7A1 rs3808607 and ABCG8 rs11887534 and rs4148217 genetic variants using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism technique.

Results
The study showed that homozygosity of rs3808607 (A-204C) genotype in CYP7A1 was significantly higher in DM2 patients (ANOVA, p<0.05) with an odd ratio of 2.66, but rs11887534 (G55C) and rs4148217 (C1199A) genetic polymorphisms in ABCG8 were found in comparable frequencies in both healthy and DM2 subjects.

Conclusions
The results of this study indicate that CYP7A1 rs3808607 genetic polymorphism is associated with DM2. Further clinical studies are required to confirm this finding among DM2 patients of Jordanian origin.
Individuelle Handlungskompetenz vs. Partizipation an sozialen Praktiken – Zugang zu Mitspielfähigkeit als gesellschaftliche Verantwortung
Authors: Daase Andrea 
Published: November 2021

Zusammenfassung
Der GER wird in seiner Verwendung für den berufsbezogenen DaZ-Unterricht und auf Basis praxeologischer Ansätze kritisch diskutiert. Statt berufssprachliche Kompetenz in den Lernenden zu verorten und ihnen die Verantwortung der Aneignung als Voraussetzung für den Zugang zu Arbeit und Beruf zu übertragen, wird ein Verständnis von Kompetenz in geteilter Handlungsträgerschaft vorgeschlagen, aus dem sich die Forderung nach Zugang zu und Teilhabe an berufssprachlichen Praktiken ableiten lässt.
Input und rezeptiver Wortschatz im Deutschen als Zweitsprache bei geflüchteten Jugendlichen in parallel geführten Intensivklassen an einer beruflichen Schule
Authors: Reez Carina , Czinglar Christine 
Published: November 2021

Zusammenfassung
Die vorliegende Studie untersucht den Zugang zur deutschen Sprache von 15 geflüchteten Jugendlichen in parallelen Intensivklassen an einer beruflichen Schule in Kassel. Mittels eines leitfadengestützten Interviews wurde die kumulative Inputmenge (in Stunden) ermittelt und mit dem rezeptiven Wortschatz der Jugendlichen verglichen. Die Ergebnisse zeigen, wie heterogen sowohl die sprachliche Umgebung als auch die Deutschkenntnisse der jugendlichen Seiteneinsteiger*innen sind, und werfen die Frage auf, inwieweit unter solchen Rahmenbedingungen ein für den Übertritt in weiterführende Bildungs- oder Ausbildungsgänge notwendiges Sprachniveau für diese Lernergruppe überhaupt erreichbar ist.
Complete reducibility of subgroups of reductive algebraic groups over non-perfect fields IV: An 𝐹4 example
Authors: Bannuscher Falk , Litterick Alastair , Uchiyama Tomohiro 
Published: November 2021

Abstract
Let 𝑘 be a non-perfect separably closed field.
Let 𝐺 be a connected reductive algebraic group defined over 𝑘.
We study rationality problems for Serre’s notion of complete reducibility of subgroups of 𝐺.
In particular, we present the first example of a connected non-abelian 𝑘-subgroup 𝐻 of 𝐺 that is 𝐺-completely reducible but not 𝐺-completely reducible over 𝑘, and the first example of a connected non-abelian 𝑘-subgroup

H
′

H^{\prime}

of 𝐺 that is 𝐺-completely reducible over 𝑘 but not 𝐺-completely reducible.
This is new: all previously known such examples are for finite (or non-connected) 𝐻 and

H
′

H^{\prime}

only.
Love Motifs in Prudentius
Authors: Moreno Soldevila Rosario 
Published: November 2021

AbstractBy analysing three paradigmatic passages, this paper explores how Prudentius uses classical love motifs and imagery not only to lambast paganism, but also as a powerful rhetorical tool to convey his Christian message. The ‘fire of love’ imagery is conspicuous inPsychomachia53–57, which wittily blends Christian and erotic language. In an entirely different context (C. Symm.2.1071–1085), theflamma amorisis also fully exploited to depict lustful young Vestal Virgins, in combination with other classical metaphors of passion, such as the ‘wound of love’ and thesigna amoris. Additionally, the contrast between heat and cold is a central element in the description of the Vestals’ tardy nuptials, redolent of classical satirical portraits ofvetulae libidinosae. Finally, inHamartigenia628–636 the relationship between the soul and God draws from a Christian tradition of bridal (and coital) representation, but the lapse into sin is portrayed as the love triangle, typical of the Latin love elegy. These examples illustrate how Prudentius creatively and consciously frames love and sex imagery in new contexts, exploring their potential and infusing clichés with new meanings and forms.
Mechanical and antibacterial properties of ZnO/chitosan bio-composite films
Authors: Kalemtas Ayse , Kocer Hasan B. , Aydin Ahmet , Terzioglu Pinar , Aydin Gulsum 
Published: November 2021

Abstract
In the current study, ZnO/chitosan bio-composite films were produced via solution-casting method. Two different ZnO powders, micrometer (d50 ≅ 1.5 μm) and nanometer sized (d50 ≅ 100 nm), were used to investigate the effect of ZnO particle size and concentration (0, 2, and 8% w/w of chitosan) on the mechanical and antibacterial properties of the ZnO/chitosan bio-composite films. The incorporation of the ZnO powders into the chitosan film resulted in an increase in the tensile strength (TS) and a decrease in the elongation at break (EB) values. Mechanical test results revealed that TS and EB properties were considerably affected (p < 0.05) by the concentration and particle size of the ZnO reinforcement. Disc diffusion method demonstrated good antibacterial activities of bio-composite films containing high amount of ZnO (8% w/w of chitosan) against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Bacillus subtilis. The growth-limiting effect of the films was more pronounced for S. aureus and K. pneumoniae. Due to enhanced TS and imparted antibacterial activity of the produced ZnO/chitosan bio-composite films, these materials are promising candidates for applications such as food packaging, wound dressing, and antibacterial coatings for various surfaces.