bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-Lubricated Polypropylene Injector for Breast Implant Delivery
Authors: Chiang Hsiao-Hung , Su Chen-Ying , Lin Hsiu-Peng , Chen Chiao-Pei , Yu Ting-Chu , Fang Hsu-Wei 
Published: August 2021

AbstractBreast augmentation is a common esthetic surgery, and there are two major surgical methods for breast implant delivery: the finger method and the plastic film method. Each method has its advantages and disadvantages, and we have developed a prelubricated polypropylene (PP) injector that might be the most suitable device for delivering breast implants. By covering the interior surface of the injector with a hydrophilic coating, the friction coefficient was significantly reduced when a silicone sled was slid against the prelubricated PP injector. To confirm if the prelubricated PP injector would not damage the breast implant, fatigue testing was performed, and the results showed that the injector did not cause rupture or microleakage of the breast implant. In addition, the cell viability result demonstrated that the prelubricated PP injector was biocompatible. In addition, the prelubricated PP injector provides a small incision site and stability during breast implant delivery. Our results provided evidence that the prelubricated PP injector is a smooth and safe method for breast implant delivery.
Sloshing of Fluid Between Rotating Inner Vertical Shaft and Stationary Outer Casing
Authors: Yonezawa Koichi , Nishimura Kosuke , Sano Takeshi , Miyagawa Kazuyoshi , Tsujimoto Yoshinobu 
Published: August 2021

Abstract
Unsteady behaviors of free surface around a rotating vertical shaft in cylindrical stationary casing were investigated. Experiments were carried out with various rotating frequency of the shaft at two initial water levels. An axi-symmetrical free surface oscillation took place when the rotational speed of the shaft became larger than a certain value. The frequency of the free surface oscillation decreased as the rotating frequency increased. A theoretical model was developed, and the mechanisms of the free surface oscillation were clarified. The oscillation was found to be a sloshing mode excited by the change of fluid angular velocity, caused by the change of wetted areas on the inner rotating shaft and outer stationary casing, associated with the change in free surface height.
In-Situ Calibrated Digital Process Twin Models for Resource Efficient Manufacturing
Authors: Adeniji David , Schoop Julius 
Published: August 2021

Abstract
The chief objective of manufacturing process improvement efforts is to significantly minimize process resources such as time, cost, waste, and consumed energy while improving product quality and process productivity. This paper presents a novel physics-informed optimization approach based on artificial intelligence (AI) to generate digital process twins (DPTs). The utility of the DPT approach is demonstrated in the case of finish machining of aerospace components made from gamma titanium aluminide alloy (γ-TiAl). This particular component has been plagued with persistent quality defects, including surface and sub-surface cracks, which adversely affect resource efficiency. Previous process improvement efforts have been restricted to anecdotal post-mortem investigation and empirical modeling, which fail to address the fundamental issue of how and when cracks occur during cutting. In this work, the integration of in-situ process characterization with modular physics-based models is presented, and machine learning algorithms are used to create a DPT capable of reducing environmental and energy impacts while significantly increasing yield and profitability. Based on the preliminary results presented here, an improvement in the overall embodied energy efficiency of over 84%, 93% in process queuing time, 2% in scrap cost, and 93% in queuing cost has been realized for γ-TiAl machining using our novel approach.
A Comparison of Characteristics of Periodic Surface Micro/Nano Structures Generated Via Single Laser Beam Direct Writing and Particle Lens Array Parallel Beam Processing
Authors: Rajab Fatema H. , Al-Jumaily Anmar K. , A.S Tayf Tariq , Stanescu Sorin Laurentiu , AlShaer Ahmad W. , Li Lin , Al-Hamd Rwayda Kh. S. 
Published: August 2021

Abstract
Changing material surface micro/nanostructures using laser beam texturing is a valuable approach in wide applications such as control of cell/bacterial adhesion and proliferation, solar cells and optical metamaterials. Here, we report a comparison of the characteristics of surface micro/nanostructures produced using single beam laser direct writing and particle lens array parallel laser beam patterning. A Nd:YVO4 nanosecond pulsed laser at the wavelength of 532 nm was used in the laser direct writing method to texture the stainless steel surface submerged in water and in air with different scanning patterns. Changes in surface morphology, wettability, surface chemistry, and optical reflectivity were analyzed. In the particle lens array method, an excimer nanosecond laser at 248 nm wavelength was adopted to produce surface patterns on GeSbTe (GST) film coated on a polycarbonate substrate by splitting and focusing a single laser beam into millions of parallel breams. Single beam laser direct writing shows that the surface of high roughness and oxygen percentage content presented high wettability and low reflectivity characteristics. However, the controllability of the type of surface micro/nanopatterns is limited. The parallel laser beam processing using particle lens array allows rapid production of user designed periodic surface patterns at nanoscale overcoming the optical diffraction limit with a high degree of controllability. Controlling the uniformity of the particle lens array is a challenge.
Clear as mud: Clinoform progradation and expanded records of the Paleocene-Eocene Thermal Maximum
Authors: Podrecca Luca G. , Makarova Maria , Miller Kenneth G. , Browning James V. , Wright James D. 
Published: August 2021

Abstract
The mid-Atlantic coastal plain (eastern United States) preserves high-resolution records of the Paleocene-Eocene Thermal Maximum (PETM) and attendant carbon isotope excursion (CIE), though preservation is highly variable from site to site. Here, we use a dip transect of expanded (as much as 15 m thick) PETM sections from the New Jersey coastal plain to build a cross-shelf PETM depositional model that explains the variability of these records. We invoke enhanced delivery of fine-grained sediments, due to the rapid environmental changes associated with this hyperthermal event, to explain relatively thick PETM deposits. We utilize δ13Cbulk, percent CaCO3, and percent coarse fraction (&gt;63 μm) data, supported by biostratigraphic records, to correlate sites along a paleoslope dip transect. Updip cores from Medford, New Jersey, preserve expanded sections of the initiation of the PETM and the earliest portion of the CIE. Medial sites (Wilson Lake, Millville) preserve an expanded CIE body, and downdip Bass River records the CIE recovery. We interpret this pattern to reflect the progradation of clinoform foresets across the paleoshelf via fluid mud, similar to modern high-sediment-supply rivers and adjacent muddy shelves (e.g., the Amazon, Mahakam [Indonesia], and Ayeyarwady [Myanmar] Rivers). Our subaqueous-clinoform delta model explains the pattern of the CIE records and provides a framework for future PETM studies in the region.
Diverse gas composition controls the Moby-Dick gas hydrate system in the Gulf of Mexico
Authors: Portnov Alexey , Cook A.E. , Vadakkepuliyambatta S. 
Published: August 2021

AbstractIn marine basins, gas hydrate systems are usually identified by a bottom simulating reflection (BSR) that parallels the seafloor and coincides with the base of the gas hydrate stability zone (GHSZ). We present a newly discovered gas hydrate system, Moby-Dick, located in the Ship Basin in the northern Gulf of Mexico. In the seismic data, we observe a channel-levee complex with a consistent phase reversal and a BSR extending over an area of ∼14.2 km2, strongly suggesting the presence of gas hydrate. In contrast to classical observations, the Moby-Dick BSR abnormally shoals 150 m toward the seafloor from west to east, which contradicts the northward-shallowing seafloor. We argue that the likely cause of the shoaling BSR is a gradually changing gas mix across the basin, with gas containing heavier hydrocarbons in the west transitioning to methane gas in the east. Our study indicates that such abnormal BSRs can be controlled by gradual changes in the gas mix influencing the shape of the GHSZ over kilometers on a basin scale.
Mentored implementation to initiate a diabetes program in an underserved community: a pilot study
Authors: Vaughan Elizabeth M , Naik Aanand D , Amspoker Amber B , Johnston Craig A , Landrum Joshua D , Balasubramanyam Ashok , Virani Salim S , Ballantyne Christie M , Foreyt John P 
Published: August 2021

IntroductionCommunity clinics often face pragmatic barriers, hindering program initiation and replication of controlled research trial results. Mentoring is a potential strategy to overcome these barriers. We piloted an in-person and telehealth mentoring strategy to implement theTelehealth-supported,Integrated Community Health Workers (CHWs),Medication-access, group visitEducation (TIME) program in a community clinic.Research design and methodsParticipants (n=55) were low-income Latino(a)s with type 2 diabetes. The study occurred in two, 6-month phases. Phase I provided proof-of-concept and an observational experience for the clinic team; participants (n=37) were randomized to the intervention (TIME) or control (usual care), and the research team conducted TIME while the clinic team observed. Phase II provided mentorship to implement TIME, and the research team mentored the clinic team as they conducted TIME for a new single-arm cohort of participants (n=18) with no previous exposure to the program. Analyses included baseline to 6-month comparisons of diabetes outcomes (primary outcome: hemoglobin A1c (HbA1c)): phase I intervention versus control, phase II (within group), and research-run (phase I intervention) versus clinic-run (phase II) arms. We also evaluated baseline to 6-month CHW knowledge changes.ResultsPhase I: compared with the control, intervention participants had superior baseline to 6-month improvements for HbA1c (mean change: intervention: −0.73% vs control: 0.08%, p=0.016), weight (p=0.044), target HbA1c (p=0.035), hypoglycemia (p=0.021), medication non-adherence (p=0.0003), and five of six American Diabetes Association (ADA) measures (p<0.001–0.002). Phase II: participants had significant reductions in HbA1c (mean change: −0.78%, p=0.006), diastolic blood pressure (p=0.004), body mass index (0.012), weight (p=0.010), medication non-adherence (p<0.001), and six ADA measures (p=0.007–0.005). Phase I intervention versus phase II outcomes were comparable. CHWs improved knowledge from pre-test to post-tests (p<0.001).ConclusionsA novel, mentored approach to implement TIME into a community clinic resulted in improved diabetes outcomes. Larger studies of longer duration are needed to fully evaluate the potential of mentoring community clinics.
Persistent neuromuscular junction transmission defects in adults with spinal muscular atrophy treated with nusinersen
Authors: Arnold W David , Severyn Steven , Zhao Songzhu , Kline David , Linsenmayer Matthew , Kelly Kristina , Tellez Marco , Bartlett Amy , Heintzman Sarah , Reynolds Jerry , Sterling Gary , Weaver Tristan , Rajneesh Kiran , Burghes Arthur H M , Kolb Stephen J , Elsheikh Bakri 
Published: August 2021

ObjectiveSpinal muscular atrophy (SMA) is a motor neuron disease caused by low levels of survival motor neuron (SMN) protein. Prior work in models and patients has demonstrated electrophysiological and morphological defects at the neuromuscular junction (NMJ). Therapeutic development has resulted in clinically available therapies to increase SMN protein levels in patients and improve muscle function. Here we aimed to investigate the effect of SMN restoration (via nusinersen) on NMJ transmission in adults with SMA.MethodsParticipants undergoing nusinersen treatment underwent 3 Hz repetitive nerve stimulation (RNS) of the spinal accessory nerve to assess compound muscle action potential amplitude decrement. Maximum voluntary isometric contraction (MVICT), Revised Upper Limb Module (RULM), and 6 min walk test (6MWT) were assessed for correlations with decrement.ResultsData from 13 ambulatory (7 men/6 women, mean age 40±11 years) and 11 non-ambulatory (3 men/8 women, mean age 38±12 years) participants were analysed. Cross-sectional analyses of RNS decrement were similar at 14 months of nusinersen (−14.2%±11.5%, n=17) vs baseline (−11.9%±8.3%, n=15) (unpaired t-test, p=0.5202). Longitudinal comparison of decrement in eight participants showed no change at 14 months (−13.9%±6.7%) vs baseline (−16.9%±13.4%) (paired t-test, p=0.5863). Decrement showed strong correlations with measures of MVICT, RULM and 6MWT but not age or disease duration.ConclusionAdults with SMA had significant NMJ transmission defects that were not corrected with 14 months of nusinersen treatment. NMJ defects were negatively associated with physical function, and thus may represent a promising target for additive or combinatorial treatments.
Revisit the correlates of infant mortality in Bangladesh: findings from two nationwide cross-sectional studies
Authors: Rahman Md Mahabubur , Ara Tasnim , Mahmud Sultan , Samad Nandeeta 
Published: August 2021

ObjectiveThe main objective of this study is to investigate how the direction and strength of the association between infant mortality and its predictors are changing over time in Bangladesh using a nationally representative sample for the period 2011–2014.Design, setting and participantsData from two repeatedly cross-sectional Bangladesh Demographic and Health Surveys (BDHSs) for the years 2011 and 2014 were used. A total of 7664 (with 312 infant death) and 7048 (with 264 infant death) complete cases, respectively, from BDHS 2011 and 2014 datasets were included in the study.MethodsCox’s proportional hazard model with robust standard error (SE) that adjusts for the complex survey design characteristics was implemented to assess how the risk factors associated with infant mortality change their paths.ResultsResults reflected that administrative division remained as a potential risk factor of infant death for both periods. Household’s socioeconomic status, father’s employment status, age difference between parents turned out to be potential risk factors in 2014, though they did not show any significant association with infant death in the year 2011. In contrast to 2011, mothers’ individual-level characteristics such as age at childbirth, education, media exposure, employment status did not remain as significant risk factors for infant death in 2014. Younger fathers increased the burden of death among infants of adolescent mothers. At higher order births, the burden of infant death significantly shifted from rural to urban areas. From the year 2011 to 2014, urban areas achieved socioeconomic equity in infant survival, while the extent of inequity was increased in rural areas.ConclusionCommunity-based programmes should be designed for urban mothers who are expecting higher order births. To eradicate the socioeconomic inequity in infant survival, the government should design strong and sustainable maternal and child healthcare facilities, especially for rural areas.
Do people with mental health problems have lower adherence to precautionary measures in COVID-19 pandemic? A cross-sectional observational study in Hong Kong
Authors: Lee Allen T C , Cheng Gabriel W H , Lin Cuichan , Wong Brian H C , Lam Linda Chiu Wa 
Published: August 2021

ObjectivesMental health problems are prevalent during the COVID-19 pandemic, but their effect on adherence to precautionary measures is not well understood. Given that psychological morbidities are associated with lower treatment adherence, and that precautionary measures are important in containing the spread of COVID-19, this study aims to determine if people with mental health problems have lower adherence to precautionary measures against COVID-19.DesignWe conducted a cross-sectional territory-wide online survey between 17 June and 31 July 2020 during the COVID-19 pandemic. Clinically significant mental health problems, adherence to precautionary behaviours, and confounding factors such as sociodemographic factors and self-reported physical health were assessed.SettingThe link to the questionnaire was disseminated to the general population in all 18 districts of Hong Kong using various social media platforms.Participants1036 individuals completed the survey. Of them, 1030 met the inclusion criteria of being adult Hong Kong residents.Primary outcomeAdherence to precautionary measures against COVID-19, including wearing face mask, frequent handwashing, household disinfection, social distancing, minimising unnecessary travel, and stocking up on food and daily essentials.ResultsOf the 1030 participants, 166 (16.1%) had clinically significant mental health problems. Interestingly, they were more likely to stock up on food and daily essentials during the pandemic (7 (4.2%) vs 15 (1.7%), p=0.04; unadjusted OR=2.49, 95% CI=1.00 to 6.21, p<0.05) and had a lesser tendency to stop social distancing even if the pandemic subsides (86 (51.8%) vs 513 (59.4%), p=0.07; unadjusted OR=0.74, 95% CI=0.53 to 1.03, p=0.07). The latter association remained significant after adjusting for the confounding factors (adjusted OR=0.68, 95% CI=0.48 to 0.96, p=0.03).ConclusionsContrary to our hypothesis, people who are mentally unwell might go beyond the recommended precautionary measures. Our findings highlight the need to identify mental health problems and provide care and support for those who might go too far with precautionary measures.Trial registration numberChiCTR 2000033936.
What to measure in biliary atresia research: study protocol for developing a core outcome set
Authors: Maguire Christopher , Tyack Zephanie , Kimble Roy M , Griffin Bronwyn Ruth , Yesberg Helen Joanna , Choo Fang Ming , McBride Craig Antony 
Published: August 2021

AimExtrahepatic biliary atresia is a rare disorder. This creates challenges in the quality and quantity of research conducted. This issue is exacerbated by the potential heterogeneity in the reported outcomes in research examining the management of biliary atresia. A core outcome set is required to standardise reporting on the management of biliary atresia in research, facilitate systematic reviews that include outcomes of greatest importance to patients and clinicians, and to evaluate the quality of the existing evidence base on the management of biliary atresia.MethodsA list of all potential outcomes will be developed through a systematic review of the literature. This list will be refined through a three-stage Delphi approach, involving key stakeholders in the management of biliary atresia. This will include patients and their parents, clinicians, nurses and allied health professionals. In this way, outcomes will be prioritised into a set of consensus core outcomes.ConclusionThe development of a core outcome set in biliary atresia management is needed to guide future research and assist in evaluating the quality of existing research.Ethics and disseminationEthical approval has been granted by the Children’s Health Queensland Hospital and Health Service Human Research Ethics Committee (HREC), Ref: HREC/20/QCHQ/62448. Results of the study will be published in an open access format.
Response strategies for promoting gender equality in public health emergencies: a rapid scoping review
Authors: Steinert Janina I , Alacevich Caterina , Steele Bridget , Hennegan Julie , Yakubovich Alexa R 
Published: August 2021

ObjectivesThe COVID-19 pandemic threatens to widen existing gender inequities worldwide. A growing body of literature assesses the harmful consequences of public health emergencies (PHEs) for women and girls; however, evidence of what works to alleviate such impacts is limited. To inform viable mitigation strategies, we reviewed the evidence on gender-based interventions implemented in PHEs, including disease outbreaks and natural disasters.MethodsWe conducted a rapid scoping review to identify eligible studies by systematically searching the databases MEDLINE, Global Health and Web of Science with the latest search update on 28 May 2021. We used the Sustainable Development Goals as a guiding framework to identify eligible outcomes of gender (in)equality.ResultsOut of 13 920 records, 16 studies met our eligibility criteria. These included experimental (3), cohort (2), case–control (3) and cross-sectional (9) studies conducted in the context of natural disasters (earthquakes, droughts and storms) or epidemics (Zika, Ebola and COVID-19). Six studies were implemented in Asia, seven in North/Central America and three in Africa. Interventions included economic empowerment programmes (5); health promotion, largely focused on reproductive health (10); and a postearthquake resettlement programme (1). Included studies assessed gender-based outcomes in the domains of sexual and reproductive health, equal opportunities, access to economic resources, violence and health. There was a dearth of evidence for other outcome domains relevant to gender equity such as harmful practices, sanitation and hygiene practices, workplace discrimination and unpaid work. Economic empowerment interventions showed promise in promoting women’s and girls’ economic and educational opportunities as well as their sexual and reproductive health during PHEs. However, some programme beneficiaries may be at risk of experiencing unintended harms such as an increase in domestic violence. Focused reproductive health promotion may also be an effective strategy for supporting women’s sexual and reproductive health, although additional experimental evidence is needed.ConclusionsThis study identified critical evidence gaps to guide future research on approaches to alleviating gender inequities during PHEs. We further highlight that interventions to promote gender equity in PHEs should take into account possible harmful side effects such as increased gender-based violence.Review registrationDOI 10.17605/OSF.IO/8HKFD.