bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification and Treatment of Primary Cervical Gestational Trophoblastic Neoplasia: a Retrospective Study of 13 Patients and Literature Review
Authors: Wang Xiaoyu , Yang Junjun , Wan Xirun , Feng Fengzhi , Zhao Jun , Ren Tong , Xiang Yang 
Published: August 2021

Abstract
Background: Primary cervical gestational trophoblastic neoplasias (GTNs) are extremely rare ectopic GTNs. Such lesions are difficult to diagnose clinically because of their rarity, with abnormal vaginal bleeding of a non-specific cause being the most common symptom. To that end, this retrospective study aimed to identify the clinical characteristics of cervical GTN and to explore diagnostic and therapeutic strategies.Results: Thirteen patients diagnosed with primary cervical GTN at the Department of Gynecology, Peking Union Medical College Hospital, Beijing, China, between June 1, 1988 and May 31, 2020 were included in the study. All patients had irregular vaginal bleeding, including six who presented with massive bleeding. Seven patients (53.8%) were initially misdiagnosed with a cervical pregnancy. All patients received chemotherapy; 11 (84.6%) also underwent hysterectomy because of chemoresistant lesions or uncontrolled bleeding. All patients achieved complete remission; however, two women (15.4%) experienced a relapse during the median follow-up period of 35 months. A comprehensive review of English-language literature published between 1980 and 2020 identified 22 case reports encompassing 27 patients. The definitive diagnosis was achieved via pathology in 26 of them (96.3%), and hysterectomy was performed in 21 (77.8%).Conclusions: Owing to its rarity and nonspecific symptoms, the diagnosis of primary cervical GTN is challenging and often relies on pathology. The combination of chemotherapy and hysterectomy is the main therapeutic strategy for this disease.
Maternal Dissatisfaction During the Postpartum Recuperation Period is an Independent Risk Factor for Postpartum Depression after Caesarean Section in China – A Prospective Cohort Study
Authors: Li Liping , Chen Chaojin , You Yiying , Muhetaer Mierzhati , Huang Fei , Pan Jingru , Zhou Shaoli , Hei Ziqing , Luo Chenfang , Wang Yanling 
Published: August 2021

Abstract
Background: Postpartum depression (PD) is a common disorder associated with severe adverse infant and maternal outcomes, which is becoming an important public health problem. However, studies on the clinical relevance of anesthesia and PD are very limited. This study aimed to examine risk factors for PD amongst Chinese parturients of caesarean section from the perspective of anesthesiology, especially during the standard Chinese postpartum recuperation period known as “doing the month”.Methods: Prospective cohort study of 125 women who received caesarean sections aged from 21 to 46 years. The Edinburgh Postnatal Depression Scale were evaluated at the day before caesarean section and 6 weeks postpartum. Demographic, clinical, and treatment, including postoperative prognostic data and conditions during “doing the month”, were recorded and compared between PD and non-PD groups. Univariable and multivariable logistic regression methods were used to explore the risk factors associated with the occurrence of PD. Results: 44 (34.9%) patients were diagnosed PD at 6 weeks postpartum. Occurrence of PD was associated with postoperative pain, pruritus, dissatisfaction with “doing the month”. Multivariate regression analysis showed that lumbago (OR 5.68, 95% CI 1.69-19.06; p=0.005), maternal total dissatisfaction during “doing the month”(OR 6.87, 95% CI 2.48-19.04; p=0.001), and dissatisfaction with mother in-law during “doing the month”(OR 3.22, 95% CI 1.43-16.16; p=0.020) were independent risk factors for PD, while mild activity pain was independent protective factor for PD 6 weeks postpartum (OR 0.018, 95% CI 0.01-0.25; p=0.003). Conclusions: PD was a commonly experienced psychological disorders for women undergoing caesarean section. Postpartum lumbago, maternal total dissatisfaction and dissatisfaction with mother in-law during “doing the month” and mild activity pain were main factors for PD at 6 weeks postpartum.
Cost-effective surveillance of an invasive species: application of info-gap theory to the Asian House Gecko Hemidactylus frenatus
Authors: Liu Yang , Wang Penghao , Thomas Melissa L. , Zheng Dan , McKirdy Simon J. 
Published: August 2021

Abstract
Invasive species can lead to community-level damage to the invaded ecosystem and extinction of native species. Most surveillance systems for the detection of invasive species are developed based on expert assessment, inherently coming with a level of uncertainty. In this research, info-gap decision theory (IGDT) is applied to model and manage such uncertainty; surveillance of the Asian House Gecko, Hemidactylus frenatus Duméril and Bibron, 1836 on Barrow Island, is used as a case study. Our research provides a novel method for applying IGDT to determine the robust population threshold (K) to trigger detection, robust-optimizing surveillance costs rather than minimizing surveillance costs. We demonstrate that increasing the population threshold for detection increases both robustness to the errors in the model parameter estimates, and opportuneness to lower surveillance costs than the accepted maximum budget. This paper provides guidance for decision makers to balance robustness and required surveillance expenditure. IGDT offers a novel method to model and manage the uncertainty prevalent in biodiversity conservation practices and modelling. The method outlined here can be used to design robust surveillance systems for invasive species in a wider context, and to better tackle uncertainty in protection of biodiversity and native species in a cost-effective manner.
Association between Postoperative Adjuvant Chemotherapy and Disease-Specific Survival in Women with Ovarian Sex Cord-Stromal Tumors: A SEER-based Study
Authors: Li Jiawei , Sun Mingming , Li Jun , Jiang Wei 
Published: August 2021

Abstract
Background Ovarian sex cord-stromal tumors (SCSTs) are relatively rare tumor. The standard treatment is surgery, while adjuvant chemotherapy remains controversial. This study evaluated the effect of adjuvant chemotherapy and disease-specific survival (DSS) in patients with SCSTs.Methods 323 Patients with SCSTs were enrolled from the Surveillance, Epidemiology, and End Results (SEER) database. Demographic and clinicopathological characteristics were compared using Mann–Whitney U-test, Fisher’s exact test, and chi-square test. DSS were estimated by Kaplan–Meier and compared with the log-rank test. Cox proportional hazards model was used to control for confounders.Results A total of 323 patients were included in this study, and the mean age was 44 years (range, 10-89 years). The most common histologic subtype was granulosa cell tumor (GCT) (n=197, 61%). 60.7% were diagnosed with stage IA or IB disease and 18% with stage IC disease. Among them, 62.2% of patients (n=201) received chemotherapy. The Median follow-up time was 71 months (range,1-224 months). 12.7% (41/323) of patients experienced death. Patients who did not received chemotherapy (n=122) had better DSS compared to those who received chemotherapy, 5-year DSS rates were 93.5% VS 80.3% (P = 0.0005), 10-year DSS rates were 93.0% and 78.69% (P = 0.0002). Multiple Cox regression analysis showed that higher stage (p＜0.001), poor differentiation（P=0.24）, larger tumor size(size＞10cm) （P=0.018） were independently associated with an increased hazard of death，while histological subtype（P=0.082）,adjuvant chemotherapy(p=0.762), complete staging surgery（p=0.554）was not associated with prognosis.ConclusionChemotherapy could not improve the prognosis and may be associated with poorer DSS. Age, histopathologic subtype, complete staging surgery, lymphadenectomy are not associated with prognosis.
Pre-procedural Determination of Device Size in Left Atrial Appendage Occlusion Using Three-dimensional Cardiac Computed Tomography
Authors: Cho Iksung , Kim William D. , Lee Oh Hyun , Cha Min Jae , Seo Jiwon , Shim Chi Young , Pak Hui-Nam , Joung Boyoung , Hong Geu-Ru , Gransar Heidi , Shin Seung Yong , Kim Jung-Sun 
Published: August 2021

Abstract
Background: The two-dimensional-based LAAO size prediction system using transesophageal echocardiography is limited by the complex structure of the left atrial appendage (LAA). The LAA anatomy can be evaluated more precisely using three-dimensional images from cardiac CT; however, a CT-based sizing method has not been established. We aimed to assess the accuracy of measurements derived from cardiac computed tomography (CT) images for selecting left atrial appendage occlusion (LAAO) devices.Methods: We retrospectively reviewed 62 patients with Amplatzer Cardiac Plug and Amulet LAAO devices who underwent implantation from 2017 to 2020. The minimal, maximal, average, area-derived, and perimeter-derived diameters of the LAA landing zone were measured using CT-based images. Predicted device sizes using sizing charts were compared with actual successfully implanted device sizes.Results: The mean size of implanted devices was 27.1 ± 3.7 mm. The perimeter-derived diameter predicted device size most accurately (mean error = -0.8 ± 2.4 mm). All other parameters showed significantly larger error (mean error; minimal diameter = -4.9 ± 3.3 mm, maximal diameter = 1.0 ± 2.9 mm, average diameter = -1.6 ± 2.6 mm, area-derived diameter = -2.0 ± 2.6 mm) than the perimeter-derived diameter (all p for difference <0.05). The error for other parameters were larger in cases with more eccentrically-shaped landing zones, while the perimeter-derived diameter had minor error regardless of eccentricity. When oversizing was used, all parameters showed significant disagreement.Conclusions: The perimeter-derived diameter on cardiac CT images provided the most accurate estimation of LAAO device size regardless of landing zone eccentricity. Oversizing was unnecessary when using cardiac CT to predict an accurate LAAO size.
Concurrent chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil for T3 N0 glottic carcinoma without vocal cord fixation
Authors: Toya Ryo , Watakabe Takahiro , Murakami Daizo , Matsuyama Tomohiko , Saito Tetsuo , Fukugawa Yoshiyuki , Nishimoto Kohei , Orita Yorihisa , Oya Natsuo 
Published: August 2021

Abstract
Background
Reports on the treatment results of chemoradiotherapy (CRT) for T3 N0 glottic carcinoma without vocal cord fixation are limited. We retrospectively evaluated the efficacy and toxicity of concurrent chemoradiotherapy (CCRT) with docetaxel, cisplatin, and 5-fluorouracil (TPF) for T3 N0 glottic carcinoma without vocal cord fixation.
Methods
Twenty-five patients were treated with TPF-CCRT. The chemotherapy consisted one or two cycles of TPF as follows: docetaxil (50 mg/m2), cisplatin (60 mg/m2), and 5-FU (600 mg/m2/day for 5 days). RT was delivered with a once-daily fraction of 2 Gy without elective nodal irradiaion (ENI). After the RT of 40 Gy and one cycle of chemotherapy, five patients (20%) were judged as having no tumor regression and underwent surgery. The remaining 20 patients underwent RT with a median total dose of 66 Gy.
Results
Of the five patients who underwent surgery after the delivery of 40 Gy, two showed residual carcinoma pathologically and the other three were confirmed to have complete pathological response to the treatment. During the follow-up period after a series of therapies, one patient had local failure. None of the patients exhibited regional or distant failure. The 5-year local control, laryngeal preservation, and overall survival rates were 87%, 92%, and 95%, respectively. Neutropenia was frequently observed during the treatment but was manageable in all the cases. No acute toxicities of grade 5 or late toxicities ≥ grade 3 were observed.
Conclusions
In this study, TPF-CCRT provided excellent tumor control with acceptable toxicities. Intensive local treatment with CCRT while omitting ENI is a reasonable approach for T3 N0 glottic carcinoma without vocal cord fixation.
Non-monotonic variation of the Kramers point band gap with increasing magnetic doping in BiTeI
Authors: Shikin A. M. , Rybkina A. A. , Estyunin D. A. , Klimovskikh I. I. , Rybkin A. G. , Filnov S. O. , Koroleva A. V. , Shevchenko E. V. , Voroshnin V. Yu. , Petukhov A. E. , Kokh K. A. , Tereshchenko O. E. , Petaccia L. , Santo G. Di , Kumar S. , Kimura A. , Skirdkov P. N. , Zvezdin K. A. , Zvezdin A. K. 
Published: August 2021

Abstract
Polar Rashba-type semiconductor BiTeI doped with magnetic elements constitutes one of the most promising platforms for the future development of spintronics and quantum computing thanks to the combination of strong spin-orbit coupling and internal ferromagnetic ordering. The latter originates from magnetic impurities and is able to open an energy gap at the Kramers point (KP gap) of the Rashba bands. In the current work using angle-resolved photoemission spectroscopy (ARPES) we show that the KP gap depends non-monotonically on the doping level in case of V-doped BiTeI. We observe that the gap increases with V concentration until it reaches 3% and then starts to mitigate. Moreover, we find that the saturation magnetisation of samples under applied magnetic field studied by superconducting quantum interference device (SQUID) magnetometer has a similar behaviour with the doping level. Theoretical analysis shows that the non-monotonic behavior can be explained by the increase of antiferromagnetic coupled atoms of magnetic impurity above a certain doping level. This leads to the reduction of the total magnetic moment in the domains and thus to the mitigation of the KP gap as observed in the experiment. These findings provide further insight in the creation of internal magnetic ordering and consequent KP gap opening in magnetically-doped Rashba-type semiconductors.
Research on Temperature Field Prediction Model of Electric Spindle Based on Improved BP Neural Network
Authors: Zhou Enwen , Zhao Yanling , Dai Ye , Zhang Jingwei , Zhang Yuan , Li He 
Published: August 2021

Abstract
The motorized spindle is the core component of CNC machine tools. In order to ensure its processing performance and processing safety, the temperature field of motorized spindle is studied. The three-dimensional model of the motorized spindle is established, and the convective heat transfer coefficient of the internal heat load and the simulation boundary condition are calculated by combining the heat transfer theory. The simulation is carried out by the finite element analysis software, and the internal temperature distribution of the motorized spindle under thermal steady state is calculated. Based on the numerical simulation analysis method and the thermal balance test method, the data basis for the prediction model of the motorized spindle temperature field is provided. The traditional BP neural network algorithm and PSO-BP neural network algorithm are used to predict the temperature of the motorized spindle measuring point under specific working conditions, and the temperature field prediction results are compared and analyzed. The results show that the PSO-BP neural network prediction model has good compatibility for variable data input, and the prediction results show little difference, which has high prediction accuracy and robustness.
Delta plus variant with neutral mutation is less virulent compared to wild type SARS-CoV2
Authors: Upadhyay Sonal , Kumar Anuj , Kumar Pradeep , Dubey Pawan K. , Tripathi Anima , Ali Akhtar , Tiwari Kavindra Nath , Bhushan Ravi 
Published: August 2021

Abstract
BackgroundWith the start of the Coronavirus disease19 (COVID19) pandemic, the Coronavirus has mutated constantly. Recently a new variant called Delta plus has been reported in few countries, including South Africa, Brazil and India. The Delta plus variant contains an additional mutation called K417N on the coronavirus spike. The present study aims to determine the virulence and transmissibility of the Delta plus variant and to check the efficiency of different antibodies on its neutralization.Materials and MethodsDifferent computational tools such as PROVEAN, an online tool, HOPE server, simulation using CABS Flex, Clus pro, an online docking tool, were used to predict the structure and function of Delta plus variant by performing a comparative study with wild type protein. Also, to find an effective antibody against Delta plus variant, antigen-antibody docking studies were conducted through Clus pro server. Furthermore, we performed a 2D interaction diagram analysis to find the amino acid residue's interaction against antibodies.Results PROVEAN and HOPE showed the mutation (K417N) in the S-glycoprotein of Delta plus as NEUTRAL mutation. This mutation causes the loss of cysteine bonds leading to the destabilization of the 3D structure of spike protein. Furthermore, the RMSF plot emphasizing the 17th amino acid position of wild and Delta plus mutant revealed the high fluctuation of mutant protein structure compared to the wild protein structure. Further, a comparative docking study against hACE2 shows higher binding energy of wild-type RBD (-751.7 kcal/mol) than mutant RBD (-750.1 kcal/mol). Moreover, antigen-antibody docking study revealed higher affinity of BD-23 Fab antibodies with greater interaction energy ( -997 kcal/mol) compared to other antibodies and thus may prove to be a promising therapeutic against Delta plus variant.ConclusionDelta plus variant is less stable, has a lower binding affinity to hACE2 and has less virulence than wild type. However, the BD-23 Fab antibody has shown a more significant association for this variant and can be used in its treatment.
Heamanite-(Ce), (K0.5Ce0.5)TiO3, a new perovskite supergroup mineral found in diamond from Gahcho Kué, Canada
Authors: Anzolini Chiara , Siva-Jothy William K. , Locock Andrew J. , Nestola Fabrizio , Balić-Žunić Tonči , Alvaro Matteo , Chinn Ingrid L. , Stachel Thomas , Pearson D. Graham 
Published: August 2021

Abstract
Heamanite-(Ce) (IMA 2020-001), ideally (K0.5Ce0.5)TiO3, is a new perovskite-group mineral found as an inclusion in a diamond from the Gahcho Kué mine in the Northwest Territories, Canada. It occurs as brown, translucent single crystals with an average maximum dimension of ~80 μm, associated with rutile and calcite. The luster is adamantine, and the fracture conchoidal. Heamanite-(Ce) is the K-analog of loparite-(Ce), ideally (NaCe)Ti2O6. The Mohs hardness is estimated to be 5½ by comparison to loparite-(Ce), and the calculated density is 4.73(1) g/cm3. Electron microprobe wavelength-dispersive spectrometric analysis (average of 34 points) yielded: CaO 10.70, K2O 7.38, Na2O 0.16, Ce2O3 13.77, La2O3 8.22, Pr2O3 0.84, Nd2O3 1.59, SrO 6.69, BaO 2.96, ThO2 0.36, PbO 0.15, TiO2 45.77, Cr2O3 0.32, Al2O3 0.10, Fe2O3 0.09, Nb2O5 0.87, UO3 0.01, total 99.98 wt%. The empirical formula, based on 3 O atoms, is: [(K0.268Na0.009)Σ0.277(Ce0.143La0.086Pr0.009Nd0.016)Σ0.254(Ca0.326Sr0.110Ba0.033Pb0.001)Σ0.470Th0.002]Σ1.003 (Ti0.979Nb0.011Cr0.007Al0.003Fe0.002)Σ1.002O3. The Goldschmidt tolerance factor for this formula is 1.003. Heamanite-(Ce) is cubic, space group Pm3m, with unit-cell parameter a = 3.9129(9) Å, and volume V = 59.91(4) Å3 (Z = 1). The crystal structure was solved using single-crystal X-ray diffraction data and refined to R1(F) = 2.61%. Heamanite-(Ce) has the aristotypic perovskite structure and adopts the same structure as isolueshite and tausonite. The six strongest diffraction lines are [dobs in angstroms (I in percentages) (hkl)]: 2.764 (100) (110), 1.954 (41) (200), 1.596 (36) (211), 1.045 (16) (321), 1.236 (13) (310), and 1.382 (10) (220). The Raman spectrum of heamanite-(Ce) shows two broad bands at 560 and 787 cm−1, with no bands observed above 1000 cm−1. Heamanite-(Ce) is named after Larry Heaman, a renowned scientist in the field of radiometric dating applied to diamond-bearing kimberlites, mantle-derived eclogites, and lamprophyre dikes. The dominant REE should appear as a Levinson suffix, hence heamanite-(Ce).
Pliniusite, Ca5(VO4)3F, a new apatite-group mineral and the novel natural ternary solid-solution system pliniusite–svabite–fluorapatite
Authors: Pekov Igor V. , Koshlyakova Natalia N. , Zubkova Natalia V. , Krzątała Arkadiusz , Belakovskiy Dmitry I. , Galuskina Irina O. , Galuskin Evgeny V. , Britvin Sergey N. , Sidorov Evgeny G. , Vapnik Yevgeny , Pushcharovsky Dmitry Yu 
Published: August 2021

Abstract
The new apatite-group mineral pliniusite, ideally Ca5(VO4)3F, was found in fumarole deposits at the Tolbachik volcano, Kamchatka, Russia, and in a pyrometamorphic rock of the Hatrurim Complex, Israel. Pliniusite, together with fluorapatite and svabite, forms a novel and almost continuous ternary solid-solution system characterized by wide variations of T5+ = P, As, and V. In paleo-fumarolic deposits at Mountain 1004 (Tolbachik), members of this system, including the holotype pliniusite, are associated with hematite, tenorite, diopside, andradite, kainotropite, baryte and supergene volborthite, brochantite, gypsum and opal. In sublimates of the active Arsenatnaya fumarole (Tolbachik), pliniusite–svabite–fluorapatite minerals coexist with anhydrite, diopside, hematite, berzeliite, schäferite, calciojohillerite, forsterite, enstatite, magnesioferrite, ludwigite, rhabdoborite-group fluoroborates, powellite, baryte, udinaite, arsenudinaite, paraberzeliite, and spinel. At Nahal Morag, Negev Desert, Israel, the pliniusite cotype and V-bearing fluorapatite occur in schorlomite-gehlenite paralava with rankinite, walstromite, zadovite-aradite series minerals, magnesioferrite, hematite, khesinite, barioferrite, perovskite, gurimite, baryte, tenorite, delafos-site, wollastonite, and cuspidine. Pliniusite forms hexagonal prismatic crystals up to 0.3 × 0.1 mm and open-work aggregates up to 2 mm across (Mountain 1004) or grains up to 0.02 mm (Nahal Morag and Arsenatnaya fumarole). Pliniusite is transparent to semitransparent, colorless or whitish, with a vitreous luster. The calculated density is 3.402 g/cm−3. Pliniusite is optically uniaxial (–), ω = 1.763(5), ε = 1.738(5). The empirical formulas of pliniusite type specimens calculated based on 13 anions (O+F+Cl) per formula unit are (Ca4.87Na0.06Sr0.03Fe0.02)Σ4.98(V1.69As0.66P0.45S0.12Si0.09)Σ3.01O11.97F1.03 (Mountain 1004) and (Ca4.81Sr0.12Ba0.08Na0.05)Σ5.06(V2.64P0.27S0.07Si0.03)Σ3.01O12.15F0.51Cl0.34 (Nahal Morag). Pliniusite has a hexagonal structure with space group P63/m, a = b = 9.5777(7), c = 6.9659(5) Å, V = 553.39(7) Å3, and Z = 2. The structure was solved using single-crystal (holotype) X-ray diffraction, R = 0.0254. The mineral was named in honor of the famous Roman naturalist Pliny the Elder, born Gaius Plinius Secundus (AD 23–79). It is suggested that the combination of high temperature, low pressure, and high oxygen fugacity favors the incorporation of V5+ into calcium apatite-type compounds, leading to the formation of fluorovanadates.