bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated fecal calprotectin is linked to psychosocial complexity in pediatric functional abdominal pain disorders
Authors: Moorman Erin L. , Farrell Michael , Santucci Neha , Denson Lee , Le Christine , Cunningham Natoshia R. 
Published: September 2021

Abstract
Objective
Children with functional abdominal pain disorders (FAPD) and clinical elevations in three risk areas (anxiety, functional disability, and pain) have been found to be at increased risk for persistent disability. We evaluated if the presence of these three risk factors corresponded with greater gastrointestinal inflammation (measured via fecal calprotectin; FC) compared to those with no risk factors. FC concentration differences between children with three risk factors and those with one and two risk factors were explored.

Results
Fifty-six children with FAPD (Mage = 12.23) completed measures of anxiety (Screen for Child Anxiety Related Disorders), disability (Functional Disability Inventory), and pain intensity (Numeric Rating Scale). Participants were stratified into risk groups (range: 0–3). Fisher’s exact tests were conducted to determine if children with three versus fewer risk factors were more likely to have elevated FC (≥ 50 µg/g) versus normal levels. Children with three risk factors (MFC = 86.04) were more likely to have elevated FC compared to children with zero (MFC = 25.78), one (MFC = 38.59), and two risk factors (MFC = 45.06; p’s < 0.05). Those with three risk factors had borderline elevated FC concentrations whereas those with fewer had normal FC concentrations. Findings suggest the importance of a biopsychosocial approach to help elucidate a FAPD phenotype.
Mesenchymal stromal cells as a therapeutic intervention for COVID-19: a living systematic review and meta-analysis protocol
Authors: Kirkham Aidan M. , Monaghan Madeline , Bailey Adrian J. M. , Shorr Risa , Lalu Manoj M. , Fergusson Dean A. , Allan David S. 
Published: September 2021

Abstract
Background
Mesenchymal stromal cells (MSCs) have significant immunomodulatory and tissue repair capabilities, mediated partly by conditioned media or through secreted extracellular vesicles (MSC-EVs). Infection with SARS-CoV-2 can cause mild to life-threatening illness due to activated immune responses that may be dampened by MSCs or their secretome. Many clinical studies of MSCs have been launched since the beginning of the global pandemic, however, few have been completed and most lack power to assess efficacy. Repeated systematic searches and meta-analyses are needed to understand, in real time, the extent of potential benefit in different patient populations as the evidence emerges.

Methods
This living systematic review will be maintained to provide up-to-date information as the pandemic evolves. A systematic literature search of Embase, MEDLINE, and Cochrane Central Register of Controlled Trials databases will be performed. All clinical studies (e.g., randomized, pseudorandomized and non-randomized controlled trials, uncontrolled trials, and case series) employing MSCs or their secretome as a therapeutic intervention for COVID-19 will be included. Patients must have confirmed SARS-CoV-2 infection. Study screening and data extraction will be performed in duplicate. Information concerning interventions, patient populations, methods of MSC isolation and characterization, primary and secondary clinical and/or laboratory outcomes, and adverse events will be extracted. Key clinical outcomes will be pooled through random-effects meta-analysis to determine the efficacy of MSCs and their secreted products for COVID-19.

Discussion
Our systematic review and subsequent updates will inform the scientific, medical, and health policy communities as the pandemic evolves to guide decisions on the appropriate use of MSC-related products to treat COVID-19.

Systematic review registration
PROSPERO CRD 42021225431
Multiple solutions for singular semipositone boundary value problems of fourth-order differential systems with parameters
Authors: Lin Longfei , Liu Yansheng , Zhao Daliang 
Published: September 2021

AbstractThe aim of this paper is to establish some results about the existence of multiple solutions for the following singular semipositone boundary value problem of fourth-order differential systems with parameters: $$ \textstyle\begin{cases} u^{(4)}(t)+\beta _{1}u''(t)-\alpha _{1}u(t)=f_{1}(t,u(t),v(t)),\quad 0< t< 1; \\ v^{(4)}(t)+\beta _{2}v''(t)-\alpha _{2}v(t)=f_{2}(t,u(t),v(t)),\quad 0< t< 1; \\ u(0)=u(1)=u''(0)=u''(1)=0; \\ v(0)=v(1)=v''(0)=v''(1)=0, \end{cases} $$

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On pairs of fuzzy dominated mappings and applications
Authors: Rasham Tahair , Asif Awais , Aydi Hassen , De La Sen Manuel 
Published: September 2021

AbstractThe main purpose of this paper is to present some fixed-point results for a pair of fuzzy dominated mappings which are generalized V-contractions in modular-like metric spaces. Some theorems using a partial order are discussed and also some useful results to graphic contractions for fuzzy-graph dominated mappings are developed. To explain the validity of our results, 2D and 3D graphs have been constructed. Also, applications are provided to show the novelty of our obtained results and their usage in engineering and computer science.
Simulation experiment to test strategies of geomagnetic navigation during long-distance bird migration
Authors: Zein Beate , Long Jed A. , Safi Kamran , Kölzsch Andrea , Wikelski Martin , Kruckenberg Helmut , Demšar Urška 
Published: September 2021

AbstractBackgroundDifferent theories suggest birds may use compass or map navigational systems associated with Earth’s magnetic intensity or inclination, especially during migratory flights. These theories have only been tested by considering properties of the Earth’s magnetic field at coarse temporal scales, typically ignoring the temporal dynamics of geomagnetic values that may affect migratory navigational capacity.MethodsWe designed a simulation experiment to study if and how birds use the geomagnetic field during migration by using both high resolution GPS tracking data and geomagnetic data at relatively fine spatial and temporal resolutions in comparison to previous studies. Our simulations use correlated random walks (CRW) and correlated random bridge (CRB) models to model different navigational strategies based on underlying dynamic geomagnetic data. We translated navigational strategies associated with geomagnetic cues into probability surfaces that are included in the random walk models. Simulated trajectories from these models were compared to the actual GPS trajectories of migratory birds using 3 different similarity measurements to evaluate which of the strategies was most likely to have occurred.Results and conclusionWe designed a simulation experiment which can be applied to different wildlife species under varying conditions worldwide. In the case of our example species, we found that a compass-type strategy based on taxis, defined as movement towards an extreme value, produced the closest and most similar trajectories when compared to original GPS tracking data in CRW models. Our results indicate less evidence for map navigation (constant heading and bi-gradient taxis navigation). Additionally, our results indicate a multifactorial navigational mechanism necessitating more than one cue for successful navigation to the target. This is apparent from our simulations because the modelled endpoints of the trajectories of the CRW models do not reach close proximity to the target location of the GPS trajectory when simulated with geomagnetic navigational strategies alone. Additionally, the magnitude of the effect of the geomagnetic cues during navigation in our models was low in our CRB models. More research on the scale effects of the geomagnetic field on navigation, along with temporally varying geomagnetic data could be useful for further improving future models.
Birds of three worlds: moult migration to high Arctic expands a boreal-temperate flyway to a third biome
Authors: Piironen Antti , Paasivaara Antti , Laaksonen Toni 
Published: September 2021

AbstractBackgroundKnowledge on migration patterns and flyways is a key for understanding the dynamics of migratory populations and evolution of migratory behaviour. Bird migration is usually considered to be movements between breeding and wintering areas, while less attention has been paid to other long-distance movements such as moult migration.MethodsWe use high-resolution satellite-tracking data from 58 taiga bean geeseAnser fabalis fabalisfrom the years 2019–2020, to study their moult migration during breeding season. We show the moulting sites, estimate the migratory connectivity between the breeding and the moulting sites, and estimate the utilization distributions during moult. We reveal migration routes and compare the length and timing of migration between moult migrants and successful breeders.ResultsAll satellite-tracked non-breeding and unsuccessfully breeding taiga bean geese migrated annually to the island of Novaya Zemlya in the high Arctic for wing moult, meaning that a large part of the population gathers at the moulting sites outside the breeding range annually for approximately three months. Migratory connectivity between breeding and moulting sites was very low (rm =  − 0.001, 95% CI − 0.1562–0.2897), indicating that individuals from different breeding grounds mix with each other on the moulting sites. Moult migrants began fall migration later in autumn than successful breeders, and their overall annual migration distance was over twofold compared to the successful breeders.ConclusionsRegular moult migration makes the Arctic an equally relevant habitat for the taiga bean goose population as their boreal breeding and temperate wintering grounds, and links ecological communities in these biomes. Moult migration plays an important role in the movement patterns and spatio-temporal distribution of the population. Low migratory connectivity between breeding and moulting sites can potentially contribute to the gene flow within the population. Moult migration to the high Arctic exposes the population to the rapid impacts of global warming to Arctic ecosystems. Additionally, Novaya Zemlya holds radioactive contaminants from various sources, which might still pose a threat to moult migrants. Generally, these results show that moult migration may essentially contribute to the way we should consider bird migration and migratory flyways.
Component gap control during posterior-stabilised total knee arthroplasty using the posterior condylar pre-cut technique
Authors: Kawasaki Makoto , Kaneyama Ryutaku , Suzuki Hitoshi , Fujitani Teruaki , Tsukamoto Manabu , Sabanai Ken , Yoshioka Toru , Okimoto Nobukazu , Nagamine Ryuji , Sakai Akinori 
Published: September 2021

Abstract
Purpose
Adjusting the gap lengths to ensure equal lengths in both extension and flexion during total knee arthroplasty (TKA) is important for achieving successful outcomes. We designed a new pre-cut trial component (PCT) for posterior-stabilised (PS) TKA and aimed to determine whether the pre-cut technique is useful for component gap (CG) control in PS TKA.

Methods
A total of 70 knees were included. The PS PCT for PS TKA is composed of a 9-mm-thick distal part and 5-mm-thick posterior part with a cam structure. First, the distal femur and proximal tibia were cut to create an extension gap. Next, a 4-mm pre-cut was made from the posterior femoral condylar line; then, the PS PCT was attached, and the CGs were checked and compared at 0° and 90° knee flexion. Final CGs with the trial femoral components were compared with gaps in PS PCT at 0° and 90° knee flexion.

Results
CGs using PS PCTs were 10.2 mm at 0° and 13.6 mm at 90° knee flexion. According to the release of the posterior capsule at intercondylar notch and the adjustment of the cutting level of posterior femoral condyle, the final CG on knee extension was 11.3 mm; it did not significantly differ from CGs with PS PCT. The final CG at 90° knee flexion was 12.7 mm; it did not significantly differ from the estimated gap (12.4 mm) in PS PCT after flexion gap control.

Conclusion
CG control using PS PCT is a useful technique during PS TKA.

Level of evidence
Level IV: Case series.
Ultrasound-based evaluation revealed reliable postoperative knee stability after combined acute ACL and MCL injuries
Authors: Lutz Patricia M. , Höher Louisa S. , Feucht Matthias J. , Neumann Jan , Junker Daniela , Wörtler Klaus , Imhoff Andreas B. , Achtnich Andrea 
Published: September 2021

AbstractPurposeAnterior cruciate ligament (ACL) injuries are often combined with lesions of the medial collateral ligament (MCL). The aim of this study was to evaluate treatment outcome of combined acute ACL and MCL lesions using functional US and clinical examination.MethodsPatients aged > 18 years undergoing primary ACL reconstruction with concomitant operative (group 1) or non-operative treatment of the MCL (group 2) between 2014 and 2019 were included after a minimum follow-up of 12 months. Grade II MCL injuries with dislocated tibial or femoral avulsions and grade III MCL ruptures underwent ligament repair whereas grade II injuries without dislocated avulsions were treated non-operatively. Radiological outcome was assessed with functional US examinations. Medial knee joint width was determined in a supine position at 0° and 30° of knee flexion in unloaded and standardized loaded (= 15 Dekanewton) conditions using a fixation device. Clinical examination was performed and patient-reported outcomes were assessed by the use of the subjective knee form (IKDC), Lysholm score, and the Tegner activity scale.ResultsA total of 40 patients (20 per group) met inclusion criteria. Mean age of group 1 was 40 ± 12 years (60% female) with a mean follow-up of 33 ± 17 months. Group 2 showed a mean age of 33 ± 8 years (20% female) with a mean follow-up of 34 ± 15 months. Side-to-side differences in US examinations were 0.4 ± 1.5 mm (mm) in 0° and 0.4 ± 1.5 mm in 30° knee flexion in group 1, and 0.9 ± 1.1 mm in 0° and 0.5 ± 1.4 mm in 30° knee flexion in group 2, with no statistically significant differences between both groups. MCL repair resulted in lower Lysholm scores (75 ± 19 versus 86 ± 15;p < 0.05). No significant differences could be found for subjective IKDC or Tegner activity scores among the two groups.ConclusionA differentiated treatment concept in combined ACL and MCL injuries based on injury patterns leads to reliable postoperative ligamentous knee stability in US-based and clinical examinations. However, grade II and III MCL lesions with subsequent operative MCL repair (group 1) result in slightly poorer subjective outcome scores.Level of evidenceRetrospective cohort study; Level III
Sugarcane bagasse: a biomass sufficiently applied for improving global energy, environment and economic sustainability
Authors: Ajala E. O. , Ighalo J. O. , Ajala M. A. , Adeniyi A. G. , Ayanshola A. M. 
Published: September 2021

AbstractSugarcane (Saccharum officinarum) bagasse (SCB) is a biomass of agricultural waste obtained from sugarcane processing that has been found in abundance globally. Due to its abundance in nature, researchers have been harnessing this biomass for numerous applications such as in energy and environmental sustainability. However, before it could be optimally utilised, it has to be pre-treated using available methods. Different pre-treatment methods were reviewed for SCB, both alkaline and alkali–acid process reveal efficient and successful approaches for obtaining higher glucose production from hydrolysis. Procedures for hydrolysis were evaluated, and results indicate that pre-treated SCB was susceptible to acid and enzymatic hydrolysis as > 80% glucose yield was obtained in both cases. The SCB could achieve a bio-ethanol (a biofuel) yield of > 0.2 g/g at optimal conditions and xylitol (a bio-product) yield at > 0.4 g/g in most cases. Thermochemical processing of SCB also gave excellent biofuel yields. The plethora of products obtained in this regard have been catalogued and elucidated extensively. As found in this study, the SCB could be used in diverse applications such as adsorbent, ion exchange resin, briquettes, ceramics, concrete, cement and polymer composites. Consequently, the SCB is a biomass with great potential to meet global energy demand and encourage environmental sustainability.
Building youth and family resilience for better mental health: developing and testing a hybrid model of intervention in low- and middle-income countries
Authors: Basu Debasish , Nagpal Sugandha , Pillai Renjith R. , Mutiso Victoria , Ndetei David , Bhui Kamaldeep 
Published: September 2021

SummaryResilience is a dynamic, multi-level, multi-systemic process of positive adaptation at the individual, family and community levels. Promoting resilience can be a cost-effective form of preventive and early intervention, offering significant health advantages for young people throughout their lives. Developing resiliency interventions for youth and their families in low- and middle-income countries (LMICs), particularly in the context of the ongoing pandemic, is especially important given a lack of services and trained specialists, and poor levels of public spend on mental health, alongside marked and clustered psychosocial disadvantages and adverse childhood experiences. We propose a ‘hybrid’ model targeting 10- to 17 year-old children and their families, and options to engage through communities, schools and the family unit. These options will enhance individual and family resilience, and possibly buffer against adversity. The adaptations respect cultural and health beliefs, take account of structural drivers of inequalities and are suitable for LMICs.
Willingness to Travel for Cellular Therapy: The Influence of Follow-Up Care Location, Oncologist Continuity, and Race
Authors: Frosch Zachary A. K. , Namoglu Esin C. , Mitra Nandita , Landsburg Daniel J. , Nasta Sunita D. , Bekelman Justin E. , Iyengar Raghuram , Guerra Carmen E. , Schapira Marilyn M. 
Published: September 2021

PURPOSE: Patients weigh competing priorities when deciding whether to travel to a cellular therapy center for treatment. We conducted a choice-based conjoint analysis to determine the relative value they place on clinical factors, oncologist continuity, and travel time under different post-treatment follow-up arrangements. We also evaluated for differences in preferences by sociodemographic factors. METHODS: We administered a survey in which patients with diffuse large B-cell lymphoma selected treatment plans between pairs of hypothetical options that varied in travel time, follow-up arrangement, oncologist continuity, 2-year overall survival, and intensive care unit admission rate. We determined importance weights (which represent attributes' value to participants) using generalized estimating equations. RESULTS: Three hundred and two patients (62%) responded. When all follow-up care was at the center providing treatment, plans requiring longer travel times were less attractive ( v 30 minutes, importance weights [95% CI] of –0.54 [–0.80 to –0.27], –0.57 [–0.84 to –0.29], and –0.17 [–0.49 to 0.14] for 60, 90, and 120 minutes). However, the negative impact of travel on treatment plan choice was mitigated by offering shared follow-up (importance weights [95% CI] of 0.63 [0.33 to 0.93], 0.32 [0.08 to 0.57], and 0.26 [0.04 to 0.47] at 60, 90, and 120 minutes). Black participants were less likely to choose plans requiring longer travel, regardless of follow-up arrangement, as indicated by lower value importance weights for longer travel times. CONCLUSION: Reducing travel burden through shared follow-up may increase patients' willingness to travel to receive cellular therapies, but additional measures are required to facilitate equitable access.
Cripping the Welfare Queen
Authors: Kim Jina B. 
Published: September 2021

AbstractDrawing together feminist- and queer-of-color critique with disability theory, this essay offers a literary-cultural reframing of the welfare queen in light of critical discourses of disability. It does so by taking up the discourse of dependency that casts racialized, low-income, and disabled populations as drains on the state, reframing this discourse as a potential site of coalition among antiracist, anticapitalist, and feminist disability politics. Whereas antiwelfare policy cast independence as a national ideal, this analysis of the welfare mother elaborates a version of disability and women-of-color feminism that not only takes dependency as a given but also mines the figure of the welfare mother for its transformative potential. To imagine the welfare mother as a site for reenvisioning dependency, this essay draws on the “ruptural possibilities” of minority literary texts, to use Roderick A. Ferguson’s coinage, and places Sapphire's 1996 novel Push in conversation with Jesmyn Ward's 2011 novel Salvage the Bones. Both novels depict young Black mothers grappling with the disabling context of public infrastructural abandonment, in which the basic support systems for maintaining life—schools, hospitals, social services—have become increasingly compromised. As such, these novels enable an elaboration of a critical disability politic centered on welfare queen mythology and its attendant structures of state neglect, one that overwrites the punitive logics of public resource distribution. This disability politic, which the author terms crip-of-color critique, foregrounds the utility of disability studies for feminist-of-color theories of gendered and sexual state regulation and ushers racialized reproduction and state violence to the forefront of disability analysis.
State Policies, Racial Disparities, and Income Support: A Way to Address Infant Outcomes and the Persistent Black-White Gap?
Authors: Pearlman Jessica , Robinson Dean E. 
Published: September 2021

Abstract
Low birth weight and preterm births vary by state, and Black mothers typically face twice the risk that their white counterparts do. This gap reflects an accumulation of psychosocial and material exposures that include interpersonal racism, differential experience with area-level deprivation such as residential segregation, and other harmful exposures that the authors refer to as “institutional” or “structural” racism. The authors use logistic regression models and a dataset that includes all births from 1994 to 2017 as well as five state policies from this period—Aid to Families with Dependent Children/Temporary Aid for Needy Families, housing assistance, Medicaid, minimum wage, and the earned income tax credit (EITC)—to examine whether these state social policies, designed to provide a financial safety net, are associated with risk reduction of low birth weight and preterm birth to Black and white mothers, and whether variations in state generosity attenuate the racial inequalities in birth outcomes. The authors also examine whether the relationship between state policies and racial inequalities in birth outcomes is moderated by the education level of the mother. We find that the EITC reduces the risk of low birth weight and preterm birth for Black mothers. The impact is much less consistent for white mothers. For both Black and white mothers, the benefits to birth outcomes are larger for mothers with less education.