bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative of meibomian gland morphology in patients with evaporative dry eye disease versus non-dry eye disease
Authors: Crespo-Treviño Ricaurte Ramiro , Salinas-Sánchez Anna Karen , Amparo Francisco , Garza-Leon Manuel 
Published: October 2021

AbstractMany recent studies have showed that morphological changes are one of the key signs of meibomian gland disease (MGD). These changes can be seen even before symptom onset, potentially underestimating the prevalence of MGD; however, until now, there is no conclusive information about the impact of meibomian gland (MG) morphology in tear film physiology and disease. This study aimed to investigate the prevalence of anatomical and morphological MG alterations between patients with evaporative dry eye disease (DED) and healthy controls. Retrospective chart review of seventy-five patients with evaporative DED and healthy individuals who had dry eye assessments included Ocular Surface Disease Index questionnaire, meibum quality, meibum expressibility, lid margin abnormality, ocular staining, non-invasive tear film break-up time, and meibography. We did not find significant differences in MG alterations in the upper lid between healthy and DED subjects. Patients with evaporative DED presented MG alterations in the lower lid more frequently than healthy subjects (54.8 vs. 30.3%; p = 0.03). The presence of shortened glands was the only MG alteration that was more prevalent in the lower lid in dry-eye patients than in healthy subjects (p < 0.05). Subjects with evaporative DED presented more alterations in the lower lid than healthy subjects.
Tyrosinase-mediated synthesis of larvicidal active 1,5-diphenyl pent-4-en-1-one derivatives against Culex quinquefasciatus and investigation of their ichthyotoxicity
Authors: Chidambaram SathishKumar , Ali Daoud , Alarifi Saud , Gurusamy Raman , Radhakrishnan SurendraKumar , Akbar Idhayadhulla 
Published: October 2021

Abstract1,5-diphenylpent-4-en-1-one derivatives were synthesised using the grindstone method with Cu(II)-tyrosinase used as a catalyst. This method showed a high yield under mild reaction conditions. The synthesised compounds were identified by FTIR, 1H NMR, 13C NMR, mass spectrometry, and elemental analysis. In this study, a total of 17 compounds (1a–1q) were synthesised, and their larvicidal and antifeedant activities were evaluated. Compound 1i (1-(5-oxo-1,5-diphenylpent-1-en-3-yl)-3-(3-phenylallylidene)thiourea) was notably more active (LD50: 28.5 µM) against Culex quinquefasciatus than permethrin(54.6 µM) and temephos(37.9 µM), whereas compound 1i at 100 µM caused 0% mortality in Oreochromis mossambicus within 24 h in an antifeedant screening, with ichthyotoxicity determined as the death ratio (%) at 24 h. Compounds 1a, 1e, 1f, 1j, and 1k were found to be highly toxic, whereas 1i was not toxic in antifeedant screening. Compound 1i was found to possess a high larvicidal activity against C. quinquefasciatus and was non-toxic to non-target aquatic species. Molecular docking studies also supported the finding that 1i is a potent larvicide with higher binding energy than the control (− 10.0 vs. − 7.6 kcal/mol) in the 3OGN protein. Lead molecules are important for their larvicidal properties and application as insecticides.
A reconfigurable intelligent surface with integrated sensing capability
Authors: Alamzadeh Idban , Alexandropoulos George C. , Shlezinger Nir , Imani Mohammadreza F. 
Published: October 2021

AbstractReconfigurable reflective surfaces can alter the propagation environment to improve wireless communication and power transfer. Paramount to this operation—which has attracted much attention recently—is the assumption that the reflective surface has prior knowledge of the propagation environment, for example, the direction/location of the transmitter and the intended receiver(s). To address this need, we propose a reconfigurable reflective metasurface with integrated sensing capabilities. By modifying the tunable meta-atoms constituting the metasurface, we couple small portions of the incident wave to an array of sensing waveguides. As an illustrative example, we demonstrate the ability to use the sampled incident wave to detect its angle of arrival. In addition, we propose and numerically demonstrate the possibility to reduce the required sensors, i.e., the number of radio frequency (RF) chains needed to acquire the sensed signals, by leveraging the inherent metasurface’s tunable multiplexing capability. A reconfigurable reflective metasurface with integrated sensing capabilities can benefit wireless communications, wireless power transfer, RF sensing, and smart sensors.
Aspiration Screening in Motor Neuron Disease: Preliminary Results From Utilization of the Yale Swallow Protocol
Authors: (Focht) Garand Kendrea L. , Suiter Debra M. , Reyes Stephanie , York Justine Dallal , Chen I-Hweii Amy 
Published: October 2021

Purpose
Dysphagia is a common symptom experienced by patients with motor neuron disease (MND). The Yale Swallow Protocol (YSP) is a validated screening instrument for identifying patients at risk for aspiration. The purpose of this exploratory cross-sectional, multicenter study was to investigate how the YSP results in identifying aspiration risk in patients with MND in comparison with aspiration observed during a videofluoroscopic swallow study (VFSS).

Method
Participants referred for VFSS as part of clinical management were recruited from four specialized MND clinics. All participants were administered the YSP immediately prior to the VFSS by a speech-language pathologist, with results recorded as pass or fail. Aspiration on VFSS was determined using the Penetration–Aspiration Scale (scores 6–8). A 2 × 2 contingency table was constructed to compare results of YSP with those on VFSS.

Results

Thirty-one patients with MND (13 males, 18 females;
M
age
= 64 ± 12 years) referred for VFSS participated in this study. Of the 22 patients who failed the YSP, interrupted drinking was the most frequent reason (65%). Compared to the VFSS, the YSP yielded a sensitivity of 80%, a specificity of 33%, positive predictive value of 36%, and negative predictive value of 78%.

Conclusions
The YSP is a simple tool and easy to utilize and has a high sensitivity in identifying aspiration risk in amyotrophic lateral sclerosis. A future investigation with a larger sample size is needed to better investigate the utility of YSP as a screening tool for this population.
Achieving the performance of the MMSE receiver with the maximum ratio combiner
Authors: Carrera Diego Fernando , Vargas‐Rosales Cesar , Azpilicueta Leyre , Granda Fausto 
Published: October 2021

AbstractIn this article, we propose a new pilot mapping method to jointly estimate the channel state information of the user while reducing the interference effects of multiuser multicell mobile scenarios. The problem of achieving the wireless performance of the minimum mean square error (MMSE) receiver with the maximum ratio (MR) combiner for massive multiple‐input multiple‐output (MIMO) systems in the frequency bands of 2.5 GHz and 28 GHz is addressed. By transmitting fewer pilots in the uplink communications and arranging those pilots to reduce interuser interference, we can achieve higher spectral efficiency (SE) with the MR and MMSE receivers. Numerical results show significantly fewer floating‐point operations for MIMO processing when the proposed pilot mapping strategy is combined with Kalman filtering estimation and MR processing, achieving an SE comparable to the MMSE receiver.
Application of adaptive chirp mode decomposition on parameter identification of sub/super‐synchronous oscillation signals
Authors: Yang Xiaomei , Li Haoyi , Mei Yubo , Hu Xunyong , Wang Yang , Xiao Xianyong 
Published: October 2021

AbstractIdentifying the parameters of sub/super‐synchronous oscillation (SubSO/SupSO) signals is challenging, because (1) the mode numbers of the oscillation signals are unknown, and (2) the oscillation signals are non‐stationary and noisy. The non‐stationary components need to be accurately identified in order to efficiently suppress SubSO/SupSO. Here, an adaptive chirp mode decomposition (ACMD) method joining a synchroextracting transform (SET) is exploited. First, for detecting the initial instantaneous frequencies (IFs) of SubSO and SupSO, SET is employed to provide time–frequency representations with satisfied energy concentration to ACMD. Second, ACMD is applied to decomposing the main components from the oscillation signal without needing to use the mode numbers, and directly compute the final IFs and instantaneous amplitudes (IAs) for SubSO and SupSO without Hilbert transform. And third, the damping factors of the SubSO and SupSO are further identified with the IAs. The proposed method is evaluated over synthetic signals, simulation data, and real field data from a wind system. Experimental results demonstrate that, compared with the classical signal decomposition‐based identification methods, the proposed method more accurately detects frequencies, amplitudes, and damping factors of SubSO and SupSO components for non‐stationary and noisy signals.
A quick fault location and isolation method for distribution network based on adaptive reclosing
Authors: Zhang Wei , Chang Zhongxue , Zhang Chenhao , Song Guobing , Tan Weibin 
Published: October 2021

AbstractFeeder automation is important to improve the reliability of power supply for distribution network. Existing voltage‐time feeder automation scheme exists the problems of long fault processing time and the upstream switches of the fault point need to tolerate fault current twice and the upstream sections need to experience two short time power outage. In this paper, a quick fault location and isolation method for distribution network based on adaptive reclosing is proposed. Three key technologies of the strategy are introduced, including a phase segregated switch of the distribution network based on the permanent magnet operating structure, the phase selector based on transient current characteristics, and the temporary fault and permanent fault identification method based on the power frequency voltage characteristics. The proposed strategy can avoid the second impact on upstream switches and power‐off of the upstream section in case of the permanent fault and can effectively shorten the fault processing time.
The Great Slump: Mrk 926 reveals discrete and varying Balmer line satellite components during a drastic phase of decline
Authors: Kollatschny Wolfram , Ochmann Martin W. , Kaspi Shai , Schumacher Claas , Behar Ehud , Chelouche Doron , Horne Keith , Müller Björn , Rafter Stephen E. , Chini Rolf , Haas Martin , Probst Malte A. 
Published: October 2021

Aims.Mrk 926 is known to be a highly variable active galactic nucleus. Furthermore, it is known to show very broad line profiles. We intended to study the continuum and line profile variations of this object with high temporal resolution in order to determine its broad-line region structure and to derive its black hole mass.Methods.We carried out a high-cadence spectroscopic variability campaign of Mrk 926 with the 10m HET telescope, aided by photometricV-band data taken with the C18 telescope at the Wise Observatory, over a period of about five months. We extracted spectroscopic continuum and line light curves, and computed cross-correlation functions (CCFs) as well as velocity-resolved CCFs with respect to the combined spectroscopic and photometricV-band light curve.Results.The continuum luminosity of Mrk 926 showed a drastic decrease during our campaign. The luminosity dropped to less than 50% of its original luminosity within only 2.5 months. Furthermore, the spectra of Mrk 926 show complex and very broad Balmer line profiles, including outer Balmer satellites ranging from ±5000 to ±13 000 km s−1. The integrated Hα, Hβ, and He Iλ5876 line light curves are delayed relative to the continuum light curve. The Hαand Hβlines show two velocity-delay structures in the central part of their line profile (within ±5000 km s−1), at ∼10 and ∼57 light-days and at ∼5 and ∼48 light-days, respectively. These structures might be interpreted as the upper and lower halves of an ellipse in the velocity-delay plane, which might be the signature of a line-emitting ring, inclined by ∼50° to the line of sight and orbiting the black hole at radii,R, of 33.5 and 26.5 light-days. We determined continuum luminosities, log(λ Lλ/erg s−1), of 43.68–44.13, which are in good agreement with the establishedRBLR − LAGNrelation. Adopting delays of 33.5 and 26.5 days for Hαand Hβ, respectively, we derive a black hole mass of (1.1 ± 0.2)×108 M⊙; this indicates a low Eddington ratio, which decreased from 8 to 3 percent during our campaign. The Balmer satellite components show a higher correlation coefficient with respect to the continuum than the central line profile, and their response to the continuum variations is on the order of only 3 − 5 days. We attribute this to the central line segment and the Balmer satellites having different, spatially distinct regions of origin.
Selective Toxicity Effect of Fatty Acids Omega-3, 6 and 9 Combination
on Glioblastoma Neurons through their Mitochondria
Authors: Seydi Enayatollah , Sadeghi Hadiseh , Ramezani Maral , Mehrpouya Leila , Pourahmad Jalal 
Published: October 2021

AbstractGlioblastoma (GBM) is one of the most common malignant tumors of the central
nervous system that occurs in the brain and is a deadly disease. Despite the
different approaches to the treatment of this malignancy, the discovery of new
compounds with anti-cancer effects seems necessary. In this study, the selective
toxicity effects of omega 3, 6 and 9 combinations on mitochondria isolated from
U87MG human glioma cells and also human embryonic kidney 293 cells (HEK293) as
normal control were investigated. The results indicated that the omega 3, 6 and
9 combinations significantly reduced succinate dehydrogenase (SDH) activity only
in mitochondria isolated from U87MG human glioma cells. Additionally, exposure
of mitochondria isolated from U87MG human glioma cells to this combination was
associated with a selective increase in the level of reactive oxygen species
(ROS), the collapse of the mitochondrial membrane potential (MMP), mitochondrial
swelling and cytochrome c release. However, these effects were not observed in
mitochondria isolated from HEK293 cells (as a normal group). According to
results, it is proposed that the combination of omega 3, 6 and 9 could induce
toxicity in U87MG human glioma cells through their mitochondria. This
combination can be helpful as a complementary therapy in patients with GBM.
Psychological Problems Experienced by Patients with Bowel Endometriosis Awaiting Surgery
Authors: Ribeiro Helizabet Salomão Abdalla Ayroza , Paiva Andresa Maria Felipe de , Taliberti Beatriz da Costa Porto , Gonçalves Anna Luiza Lobão , Condes Renata Pereira , Ribeiro Paulo Augusto Galvão Ayroza 
Published: October 2021

AbstractObjective To assess the most common psychological disturbances in women with deep endometriosis and bowel involvement who are waiting surgical treatment and to evaluate what forms of coping are used to solve the problem.Methods This was a cross-sectional observational study of 40 women diagnosed with deep endometriosis and intestinal symptoms. They completed two questionnaires: one for anxiety and depression (Hospital Anxiety and Depression Scale [ HADS]) and the Scale of Mode of Confronting Problems (EMEP, in the Portuguese acronym).Results We found that 77.1% of the patients had anxiety and depression, with anxiety being the most prevalent (87.5% of the patients); 90% of the patients used problem-focused and religious introspection as their main modes of confronting problems.Conclusion In the use of the HADS questionary, two psychological aspects were the most present in women with deep endometriosis awaiting surgical treatment: anxiety and depression. The most used forms of coping to solve the problem were problem-coping and religious practices.
Review of extremity dosimetry in nuclear medicine
Authors: Kollaard Robert , Zorz Alessandra , Dabin Jérémie , Covens Peter , Cooke Jennie , Crabbé Melissa , Cunha Lidia , Dowling Anita , Ginjaume Mercè , McNamara Leanne 
Published: October 2021

Abstract
The exposure of the fingers is one of the major radiation protection concerns in nuclear medicine (NM). The purpose of this paper is to provide an overview of the exposure, dosimetry and protection of the extremities in NM. A wide range of reported finger doses were found in the literature. Historically, the highest finger doses are found at the fingertip in the preparation and dispensing of 18F for diagnostic procedures and 90Y for therapeutic procedures. Doses can be significantly reduced by following recommendations on source shielding, increasing distance and training. Additionally, important trends contributing to a lower dose to the fingers are the use of automated procedures (especially for positron emission tomography (PET)) and the use of prefilled syringes. On the other hand, the workload of PET procedures has substantially increased during the last ten years. In many cases, the accuracy of dose assessment is limited by the location of the dosimeter at the base of the finger and the maximum dose at the fingertip is underestimated (typical dose ratios between 1.4 and 7). It should also be noted that not all dosimeters are sensitive to low-energy beta particles and there is a risk for underestimation of the finger dose when the detector or its filter is too thick. While substantial information has been published on the most common procedures (using 99mTc, 18F and 90Y), less information is available for more recent applications, such as the use of 68Ga for PET imaging. Also, there is a need for continuous awareness with respect to contamination of the fingers, as this factor can contribute substantially to the finger dose.
Lifetime measurement of the 260 g.s. at SAMURAI
Authors: Storck S , Caesar C , Kahlbow J , Panin V , Ahn D S , Atar L , Aumann T , Baba H , Boretzky’ K , Chae H , Chiga N , Choi S , Cortés M L , Cortina-Gil D , Deshayes Q , Doornenbal P , Elekes Z , Fukuda N , Gašparić I , Hahn K I , Halász Z , Hirayama A , Hwang J , Inabe N , Isobe T , Kim S , Kobayashi T , Körper D , Marques M , Matsumoto M , Murakami T , Murray I , Nakamura T , Nilsson T , Otsu H , Paschalis S , Parlog M , Petri M , Rossi D , Saito A , Sasano M , Scheit H , Schrock P , Shimizu Y , Simon H , Sohler D , Sorlin O , Stuhl L , Suzuki H , Syndikus I , Takeda H , Törnqvist H , Togano Y , Tomai T , Uesaka T , Yamada H , Yang Z , Yasuda M , Yoneda K I 
Published: October 2021

Abstract
The ground state of the neutron unbound nucleus 26O is speculated to have a lifetime in the pico-second regime. In order to determine the decay lifetime of the 26 O ground state with high sensitivity and precision, a new method has been applied. The experiment was performed in December 2016 at the Superconducting Analyzer for MUlti-particle from Radio Isotope Beams (SAMURAI) at the Radioactive Isotope Beam Factory (RIBF) at RIKEN. A 27F beam was produced in the fragment separator BigRIPS and impinged on a W/Pt target 26
O
26
O outside the target. Thus, the velocity difference between the decay neutrons and the fragment 1 O delivers a characteristic spectrum from which the lifetime can be extracted.
Possible influence of the warm pool ITCZ on compound climate extremes during the boreal summer
Authors: Basconcillo Joseph , Moon Il-Ju , Wang Bin , Mistry Malcolm 
Published: October 2021

Abstract
In a globally changing climate, there is a growing concern for understanding and predicting compound climate extremes. However, the relationship of compound climate extremes with each other has been mostly analyzed in isolation and/or on regional scales. Little attention has been paid to their simultaneous occurrence and compound impacts worldwide. Here we demonstrate that the compound climate extremes in the Northern Hemisphere during the boreal summer are interconnected from the tropics to the Arctic. This connection originates from the interannual variations of the Indo-Pacific warm pool’s intertropical convergence zone (ITCZ). We demonstrate that the warm pool ITCZ (WPI) convection possibly influences three major teleconnection patterns (i.e. zonal, meridional, and circumglobal) where compound climate extremes occur along the wave train excited by the WPI convection. Most notably, the WPI can sufficiently explain climate variabilities in the North Atlantic region, which influences the occurrence of compound climate extremes in many parts of Europe and North America. Our findings advance the understanding of the interannual global/regional variability of climate extremes and are potentially valuable for predicting seasonal high-impact climate extremes.
On the localization of measure induced Toeplitz operators on the Bergman space
Authors: Zorboska Nina 
Published: October 2021

We prove that a Toeplitz operator with a complex Borel measure symbol whose total variation is Carleson is strongly localized, thus improving the recent localization results from Sadeghi and Zorboska [J. Math. Anal. Appl. 485 (2020), p. 16]. We also show that as a corollary, we get yet another view of some of the previously known results on Toeplitz operators with BMO symbols.
Identification of Hemoglobin Variants Prevalent in China and Their Effects on Hemoglobin A1c Measurements
Authors: Xu Anping , Chen Weidong , Xu Miao , Xie Weijie , Ji Ling 
Published: October 2021

Abstract

Objectives
We aimed to evaluate the effects of hemoglobin (Hb) variants prevalent in China on HbA1c measurements and to identify them during HbA1c measurements.

Methods
We evaluated a cation-exchange high-performance liquid chromatography (HPLC) method (Bio-Rad D-100), a capillary electrophoresis (CE) method (Capillarys 3 TERA), an immunoassay (Cobas c501), and a boronate affinity method (Premier Hb9210, as a comparative method) for HbA1c measurements in the presence of Hb variants prevalent in China.

Results
The Bio-Rad D-100 and Capillarys 3 TERA gave specific retention times and numeric migration positions for each Hb variant, respectively, showing excellent interindividual reproducibility. All methods showed statistically significant differences (P &lt; .01) for several variants. Clinically significant effects were observed for the Bio-Rad D-100 (Hb New York and Hb J-Bangkok), Capillarys 3 TERA (Hb New York and Hb J-Bangkok), and Cobas c501 (Hb New York). Among 297 samples with Hb variants, there were 75 (25.3%) unacceptable results for Bio-Rad D-100, 28 (9.4%) for Capillarys 3 TERA, and 19 (6.4%) for Cobas c501 compared with the results from Premier Hb9210.

Conclusions
Some Hb variants prevalent in China affect HbA1c measurements. The HPLC retention time and CE migration position can aid in the presumptive identification of Hb variants.
Controlling the microbial composition during the fermentation of Ishizuchi-kurocha
Authors: Li Zuoqian , Jiang Lei , Wei Lingdong , Ohno Tomoki , Syaputri Yolani , Horie Masanori , Iwahashi Hitoshi 
Published: October 2021

ABSTRACT
Ishizuchi-kurocha is a popular postfermented tea in Japan. It is performed by domestic and natural fermentation relied on microorganisms derived from tea leaves or the environment of the manufacturing. Ishizuchi-kurocha undergoes aerobic fermentation of fungi first, then second fermented by anaerobic fermentation of lactic acid bacteria during natural fermentation processing. Aspergillus niger that produces mycotoxin is included in natural fermentation. This research aimed to build a novel fermentation method of Ishizuchi-kurocha by adding industrial koji fungi products and laboratory-cultivated Lactobacillus plantarum (Lactiplantibacillus plantarum) artificially. Thus, safety and quality of tea products could be controlled simply. We found artificial fermentation of Ishizuchi-kurocha could get high lactic acid production within 8 days. Final products only consisted of genus Aspergillus and genus Lactobacillus, while harmful Aspergillus niger was not found. However, artificial fermentation methods also decreased the content of polyphenols when compared with commercial tea.