bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasound-Guided Intraosseous Injection of Bone Marrow Aspirate Concentrate for a Basketball Player With Bilateral Tibial Nonunion Fractures
Authors: Hussain Farah S. , Olufade Oluseun A. 
Published: December 2024

Abstract:
We present a case of a professional basketball player who suffered from nonunion bilateral chronic tibial fractures, successfully treated with ultrasound-guided intraosseous injection with bone marrow aspirate concentrate. The patient was able to return to play full time after recovery from the procedure.
Influence of phytosomal curcumin on anthropometric indices for nonalcoholic fatty liver disease: A meta-analysis
Authors: Liu Nana , Li Hongting 
Published: December 2024

Background:
Phytosomal curcumin may have some potential in improving anthropometric indices for nonalcoholic fatty liver disease, and this meta-analysis aims to study the effect of phytosomal curcumin on anthropometric indices for nonalcoholic fatty liver disease.

Methods:
We have searched several databases including PubMed, EMbase, Web of science, EBSCO and Cochrane library databases, and selected the randomized controlled trials (RCTs) comparing phytosomal curcumin with placebo for nonalcoholic fatty liver disease. This meta-analysis was conducted using the random-effect or fixed-effect model based on the heterogeneity.

Results:
Seven RCTs were included in this meta-analysis. Compared with placebo in nonalcoholic fatty liver disease, phytosomal curcumin was associated with substantially reduced body mass index (BMI, mean difference [MD] = −0.72; 95% confidence interval [CI] = −1.11 to −0.33; P = .0003), body fat percent (MD = −2.04; 95% CI = −3.10 to −0.98; P = .0002), weight (MD = −2.15; 95% CI = −3.78 to −0.53; P = .01) and waist circumference (MD = −2.09; 95% CI = −4.05 to −0.12; P = .04), but showed no influence on hip circumference (MD = −0.06; 95% CI = −0.59 to 0.47; P = .83) or waist/hip ratio (MD = 0; 95% CI = −0.01 to 0.01; P = 1).

Conclusions:
Phytosomal curcumin is effective to improve anthropometric indices for patients with nonalcoholic fatty liver disease.
Effect of sodium zirconium cyclosilicate on hyperkalemia after parathyroidectomy in secondary hyperparathyroidism patients with maintenance hemodialysis: A randomized trial
Authors: Kang Jing , Li Sijia , Su Jinglin , Xiao Zhixue , Zhang Siyi , Liu Shuangxin , Ge Pingjiang 
Published: December 2024

Background:
Postoperative hyperkalemia is 1 common complication after parathyroidectomy (PTX), which requires close monitoring and prompt treatment. This study aimed to determine whether using sodium zirconium cyclosilicate (SZC) would lower the risk of hyperkalemia in patients with maintenance hemodialysis after PTX.

Methods:
Sixty-two patients with secondary hyperparathyroidism (SHPT) were randomly divided into the experimental and control groups. Patients in the experimental group were required to take 10 g of SZC before PTX. Laboratory chemistries were obtained before and after surgery.

Results:
Parathyroid hormone (PTH) decreased dramatically in the experimental and control groups after PTX. There were no significant differences in serum potassium ion (K+) between the 2 groups at 6 am on the day of surgery and immediately after surgery. However, serum potassium in the experimental group at 9 pm on the day of surgery was significantly lower than in the control group. Three patients with severe hyperkalemia in the control group received emergency hemodialysis or insulin and glucose treatment, while none in the experimental group required hemodialysis. Serum calcium levels declined immediately after the operation, but no significant differences were found between these 2 groups at all time points.

Conclusion:
SZC has the potential to reduce the occurrence of hyperkalemia and avoid urgent hemodialysis after PTX. We recommended that SZC could be used routinely in SHPT patients on the day of PTX surgery.
Hemorrhagic liver cyst misdiagnosed as echinococcosis in a Tibetan woman: A case report
Authors: Wang Shuang , He Yan , He Xuchang , Wang Jun 
Published: December 2024

Rationale:
We describe a case of hepatic cyst with intracystic bleeding that was preoperatively misdiagnosed as hepatic echinococcosis. Pain in the right upper quadrant of the abdomen was the first symptom to appear. In addition to highlighting the significance of imaging in distinguishing hepatic cyst with intracystic bleeding from other cystic liver tumors, we also talk about the difficulties and obstacles encountered throughout the diagnosis and treatment of this case. More imaging evidence for the diagnosis of hepatic cyst with intracystic bleeding is anticipated in this patient.

Patient concerns:
A 24-year-old Tibetan female was admitted to the hospital due to swelling and pain in the right upper abdomen for more than 1 month.

Diagnoses:
The patient had a history of living in the epidemic area, serum echinococcosis antibody was positive, and abdominal computed tomography plain enhanced scan showed a low-density cystic space-occupying lesion in the right lobe of the liver, with a high-density mass in the cyst, which was misdiagnosed as cystic hepatic echinococcosis before operation. Postoperative pathological examination confirmed old hemorrhage in hepatic cysts, and no parasitic infectious lesions such as Echinococcus granulosus were found.

Interventions:
After perfecting the relevant preoperative preparation, the patient underwent right hemihepatectomy plus portal vein and vena cava repair.

Outcomes:
The patient was discharged from the hospital 5 days after operation.

Lessons:
The differential diagnosis of individuals with a history of residing in an epidemic region and liver space-occupying lesions on imaging should take into account more than only the probability of hepatic echinococcosis, as this case highlights. When making a differential diagnosis of different types of cystic liver tumors, imaging testing is crucial.
Lobular endocervical glandular hyperplasia: Two case report and literature review
Authors: Tang Shenglan , Jiang Xuelu , Wang Xue 
Published: December 2024

Rationale:
Lobular endocervical glandular hyperplasia is a rare proliferative lesion of the endocervical glands with an unclear pathogenesis. The condition lacks specific clinical manifestations and signs and often leading to clinical underdiagnosis and misdiagnosis.

Patient concerns:
A 27-year-old female patient presented with a history of abnormal vaginal bleeding over the previous 3 months. An ultrasound examination revealed the presence of a cystic solid structure in the posterior wall of the cervix.
The second patient is a 25-year-old woman who has undergone 3 cervical cystectomies over the past 9 years due to recurrent cervical cysts. It is regrettable to report that the cyst has now recurred.

Diagnoses:
Lobular endocervical glandular hyperplasia.

Interventions:
In consideration of the fertility needs of both patients, the gynecologists conducted a comprehensive imaging evaluation and detailed preoperative discussion, and performed ultrasound-guided hysteroscopic excision of cervical lesions and transvaginal excision of cervical lesions.

Outcomes:
Following treatment, the 2 patients exhibited a complete resolution of their clinical symptoms. Subsequent follow-up examinations demonstrated that both patients were exhibiting favorable outcomes.

Lessons:
The objective of this study is to present 2 cases of lobular endocervical glandular hyperplasia in order to facilitate a greater understanding of this rare disease among gynecologists. Furthermore, this study will describe the potential use of ultrasound-guided hysteroscopic excision of cervical lesions and transvaginal hysteroscopic excision of cervical lesions as a treatment modality for lobular endocervical glandular hyperplasia patients with fertility needs.
Anti-sulfatide antibody-positive Guillain–Barré syndrome in adults following off-craniotomy for cerebellar contusion: A case report
Authors: Min Xiaobin , Feng Haoye , Zhao Riguang , Guo Zhigang , Su Hongjun 
Published: December 2024

Rationale:
Gullain–Barré syndrome (GBS) is a rare autoimmune condition primarily presenting with symmetrical progressive limb weakness. It is frequently associated with sensory and autonomic symptoms and autonomic disturbances and often manifests seropositivity for anti-ganglioside antibodies. Infections are considered major precipitants; however, GBS post-craniotomy for severe traumatic brain injury is a rarity.

Patient concerns:
A 79-year-old female underwent craniotomy for a cerebellar contusion sustained from severe traumatic brain injury, leading to quadriplegia, autonomic dysfunction, dilated pupils, and respiratory failure. However, the patient’s GBS manifested slightly differently. Her limb weakness was asymmetric and progressed from 1 upper limb to the other.

Diagnoses:
The diagnosis of GBS was confirmed based on clinical presentation, cerebrospinal fluid analysis showing albuminocytologic dissociation, and the detection of anti-sulfatide antibodies in serum.

Interventions:
The patient received intravenous immunoglobulin (IVIG) therapy at 2 g/kg daily, along with supportive measures including mechanical ventilation and rehabilitation.

Outcomes:
The patient demonstrated significant improvement within 5 days of IVIG treatment, achieving near-complete functional recovery with grade 4 muscle strength at discharge 6 weeks post-intervention.

Lessons:
This case highlights the need to consider GBS in postoperative patients with acute limb weakness, even in atypical presentations. Early recognition and timely IVIG treatment are critical for favorable outcomes.
The value of pelvic peritoneal reconstruction during abdominoperineal resection for rectal cancer: A systematic review and meta-analysis
Authors: Wang Jian , Yang Xingwen , Hao Mengdi 
Published: December 2024

Background:
To systematically evaluate the significance of pelvic peritoneal reconstruction during abdominoperineal resection for rectal cancer, specifically focusing on its impact on the incidence of postoperative complications, in order to provide recommendations for clinical medical practice.

Methods:
We performed a thorough literature search using multiple databases, including PubMed, Web of Science (which includes MEDLINE), the Chinese National Knowledge Infrastructure database, and the Wan-Fang database. The search was updated until May 20, 2023, and included articles published from the earliest available dates. The selected literature was assessed for quality, and data extraction was conducted. The extracted data were then subjected to meta-analysis using RevMan 5.4 software.

Results:
A total of 16 cohort studies were included, with publication dates ranging from 2012 to 2021, including 9 prospective cohort studies and 7 retrospective cohort studies. These studies consisted of both a pelvic peritoneal closure (PPC) group and a non-closure group. The meta-analysis revealed that patients in the PPC group had significantly lower incidence rates of the following postoperative complications compared to the non-PPC group, with statistical significance observed (P < .05): intestinal obstruction (odds ratio [OR] = 0.22, 95% confidence intervals [CI]: 0.14–0.36, P < .01), surgical site infection (OR = 0.36, 95% CI: 0.24–0.55, P < .01), pelvic and abdominal cavity infection (OR = 0.20, 95% CI: 0.05–0.79, P < .05), pelvic and abdominal cavity infection (OR = 0.17, 95% CI: 0.07–0.39, P < .01).

Conclusion:
Our findings indicate that pelvic peritoneal reconstruction during the surgical procedure holds promise in reducing the occurrence of adverse postoperative events and may have substantial clinical implications for the management of rectal cancer.
Lemierre syndrome: case presentation of a life-threatening septic pneumonia with complicated parapneumonic effusion: A case report
Authors: Kim Tae Hun , Youn Seong Hwan , Kim Mi-Ae , Kim Hyun Jung , Kwon Yong Shik , Park Jae Seok , Park Sun Hyo 
Published: December 2024

Rationale:
Lemierre syndrome is a rare, life-threatening complication of oropharyngeal infections.

Patient concerns:
A 35-year-old man started with an upper respiratory infection but worsened the clinical course with sepsis and acute respiratory failure with complicated bilateral pleural effusion.

Diagnoses:
The patient was diagnosed with typical Lemierre syndrome with lung complications.

Interventions:
Antibiotic therapy with bilateral pleural percutaneous drain with fibrinolysis.

Outcomes:
The patient improved and was discharged without oxygen therapy after antibiotics were covered and active lung care with complicated parapneumonic effusion. After discharge, lung function showed restrictive lung defect but improved compared to the initial exam.

Lessons:
Lemierre syndrome, which might begin as a mild upper respiratory infection, can progress to a critically ill disease accompanied by sepsis and metastatic septic embolus. The patient suffered septic lung emboli with bilateral complicated parapneumonic effusion but was successfully treated with percutaneous drainage with pleural fibrinolysis, appropriate antibiotics, and anticoagulants. Early suspicion of the disease and active treatment are necessary to treat rare syndromes like Lemierre syndrome.
Efficacy and safety of red ginseng extract powder (KGC05pg) in achieving glycemic control in prediabetic Korean adults: A 12-week, single-center, randomized, double-blind, parallel-group, placebo-controlled study
Authors: Jeong Yoonseon , Lee Seung Ho , Shim Sung Lye , Jang Kyoung Hwa , Kim Jong Han 
Published: December 2024

Background:
This study was conducted to assess the efficacy and safety of Red Ginseng Extract Powder (RGEP) (KGC05pg; Korea Ginseng Corporation, Daejeon, Korea) in achieving glycemic control in prediabetic Korean adults.

Methods:
The patients of the RGEP group (n = 49) and those of the placebo group (n = 49) were orally given 2 tablets of RGEP and its matching placebo, respectively, at a dose of 500 mg/day twice daily in the morning and the evening within 30 min after meal during a 12-week treatment period. The patients were assessed for glycemic control parameters, such as fasting blood glucose levels, 30-, 60-, 90-, and 120-min blood glucose levels on an oral glucose tolerance test, Hb1Ac levels and glucose area under the curve, insulin resistance parameters, such as homeostasis model assessment of insulin resistance, c-peptide and insulinogenic index, and hormone parameters, such as glucagon, adiponectin and glucagon-like peptide-1. Moreover, the patients were also assessed for time-dependent changes in dipeptidyl peptidase-4 levels. Finally, the patients were also assessed for incidences of treatment-emergent adverse events and serious adverse events.

Results:
There were significant differences in changes in fasting blood glucose and 30-, 60-, 90-, and 120-min blood glucose levels on an oral glucose tolerance test, Hb1Ac levels, glucose area under the curve, homeostasis model assessment of insulin resistance, c-peptide levels and insulinogenic index, glucagon, adiponectin, and glucagon-like peptide-1 levels at 12 weeks from baseline between the 2 groups (P < .05). There was a significant time-dependent decrease in dipeptidyl peptidase-4 levels in the RGEP group (P = .001). There were no cases of treatment-emergent adverse events and serious adverse events in each treatment arm.

Conclusion:
RGEP might be effective in achieving glycemic control in prediabetic Korean adults.
Observational comparison of fatigue and sleep disturbance after traumatic injury, in those with and without concomitant mild traumatic brain injury
Authors: Anderson Jacqueline F. I. , Park Jeong In 
Published: December 2024

Abstract

Objective
Fatigue and subjective sleep disturbance are elevated after mild traumatic brain injury (mTBI), raising the question of whether mTBI-specific factors contribute to the experience of fatigue and subjective sleep disturbance after mTBI.

Design
110 premorbidly healthy individuals who had suffered a traumatic injury during an accident approximately 8 weeks prior were examined and assessed with subjective measures of fatigue and sleep disturbance, psychological distress and pain.

Results
Individuals with a traumatic injury reported significant elevations in most fatigue and all subjective sleep disruption components compared to community-based control participants (n = 45). After controlling for pain, psychological status, sex and premorbid intellectual functioning, those individuals experiencing a mTBI at time of traumatic injury (n = 64) had equivalent levels of fatigue and subjective sleep disruption as those who had experienced no head injury at time of traumatic injury (n = 46). Trauma group membership did not significantly predict fatigue or subjective sleep disturbance. In contrast, psychological distress consistently predicted fatigue and subjective sleep disturbance, with pain also inconsistently predicting some fatigue and subjective sleep disturbance variables.

Conclusion
This study suggests it is the experience of suffering traumatic injury, rather than mTBI-specific factors, that is associated with elevations in fatigue and subjective sleep disturbance, approximately 8 weeks after injury.
Application of 99mTc-FAPI-46 Imaging in a Patient With Medullary Thyroid Carcinoma
Authors: Raeisi Nasrin , Saber Tanha Amin , Barashki Somayeh , Nateghi Navid , Aryana Kamran 
Published: December 2024

Abstract
We present the case of a 58-year-old man with metastatic medullary thyroid carcinoma refractory to conventional therapies, including peptide receptor radionuclide therapy. Despite multiple interventions, serum calcitonin and carcinoembryonic antigen levels continued to rise. Subsequent evaluation with 99mTc-FAPI-46 revealed remarkable uptake in metastatic lesions, suggesting a potential role for FAPI-labeled radioisotopes in the management of medullary thyroid carcinoma. This case underscores the emerging utility of FAPI-targeted radiotracers in oncologic nuclear medicine and highlights the need for further research in this promising area.
Evaluating Chatbots in Psychiatry: Rasch-Based Insights into Clinical Knowledge and Reasoning
Authors: Chang Yu , Huang Si-Sheng , Hsu Wen-Yu , Liu Yi-Chun 
Published: December 2024

AbstractChatbots are increasingly being recognized as valuable tools for clinical support in psychiatry. This study systematically evaluates their strengths and limitations in psychiatric clinical knowledge and reasoning. A total of 27 chatbots, including ChatGPT-o1-preview, were assessed using 160 multiple-choice questions derived from the 2023 and 2024 Taiwan Psychiatry Licensing Examinations. The Rasch model was employed to analyze chatbot performance, supplemented by dimensionality analysis and qualitative assessments of reasoning processes. Among the models, ChatGPT-o1-preview achieved the highest performance, with a JMLE ability score of 2.23, significantly exceeding the passing threshold (p < 0.001). It excelled in diagnostic and treatment reasoning and demonstrated a strong grasp of psychopharmacology concepts. However, limitations were identified in its factual recall, handling of niche topics, and occasional reasoning biases. Building on these findings, we have highlighted key aspects of a potential clinical workflow to guide the practical integration of chatbots into psychiatric practice. While ChatGPT-o1-preview holds significant potential as a clinical decision-support tool, its limitations underscore the necessity of human oversight. Continuous evaluation and domain-specific training are crucial to maximize its utility and ensure safe clinical implementation.
“I wish I could work on school stuff.” Investigating the Impact of Remote Learning on Undergraduate Students’ Academic Success and Mental Health during the COVID-19 Lockdown
Authors: Nano Joseph P. , Catterall William A. , Chang Michael L. , Ghaly Mina H. 
Published: December 2024

AbstractObjectiveTo investigate how remote learning has affected undergraduate students’ learning abilities, academic success, and mental health during the COVID-19 pandemic.MethodsThis cross-sectional study took place between April and June 2020 in the United States. Participants completed a survey consisting of demographic questions, Depression, Anxiety, and Stress Scale-21 Items (DASS-21), and an open-ended question. We used a logistic regression model on objective variables and conducted a systematic thematic analysis of the open-ended response.ResultsOur final sample consisted of 1,173 full-time undergraduate students in the United States. Most participants were public university students (n = 835, 71%) and reported that moving to remote learning had a negative impact on their school performance (n=802, 68%). Positive experiences in remote learning were associated with moving to their family’s house (p<0.05), living on campus in a dorm (p<0.05), and no internet issues during classes (p<0.0001). From the thematic analysis, we found six common themes among those who reported having a negative experience with remote learning: (1) adjusting to school, (2) dealing with mental health difficulties, (3) lack of motivation to do work, (4) adjusting to home environment, (5) feeling uncertain about occupational opportunities, and (6) disagreement in political views.LimitationsThe results of this study may not be generalizable to undergraduate students outside of the United States due to differences in lockdown restrictions.ConclusionRemote learning during COVID-19 had a negative impact on the majority of undergraduate students’ academic performance and mental health.Highlights❖ The majority of undergraduate students reported that remote learning negatively impacted their school performance.❖ Students with non-STEM college majors experienced higher levels of stress, anxiety, and depression compared to students with STEM college majors.❖ We found six common themes related to negative experiences with remote learning.
An Interbacterial Cysteine Protease Toxin Inhibits Cell Growth by Targeting Type II DNA Topoisomerases GyrB and ParE
Authors: Song Pin-Yi , Tsai Chia-En , Chen Yung-Chih , Huang Yu-Wen , Chen Po-Pang , Wang Tzu-Haw , Hu Chao-Yuan , Chen Po-Yin , Ku Chuan , Hsia Kuo-Chiang , Ting See-Yeun 
Published: December 2024

AbstractBacteria deploy a diverse arsenal of toxic effectors to antagonize competitors, profoundly influencing the composition of microbial communities. Previous studies have identified an interbacterial toxin predicted to exhibit proteolytic activity that is broadly distributed among Gram-negative bacteria. However, the precise mechanism of intoxication remains unresolved. Here, we demonstrate that one such protease toxin fromEscherichia coli, Cpe1, disrupts DNA replication and chromosome segregation by cleaving conserved sequences within the ATPase domain of type II DNA topoisomerases GyrB and ParE. This cleavage effectively inhibits topoisomerase-mediated relaxation of supercoiled DNA, resulting in impaired bacterial growth. Cpe1 belongs to the papain-like cysteine protease family and is associated with toxin delivery pathways, including the type VI secretion system and contact-dependent growth inhibition. The structure of Cpe1 in complex with its immunity protein reveals a neutralization mechanism involving competitive substrate binding rather than active site occlusion, distinguishing it from previously characterized effector-immunity pairs. Our findings unveil a unique mode of interbacterial intoxication and provide insights into how bacteria protect themselves from self-poisoning by protease toxins.