bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minería y cambio climático en la cuenca del Tunjuelo: una experiencia de formación política en la escuela
Authors: Hernández Gómez Carmen Alicia , Vargas Aldana Claudia María 
Published: August 2021

El reto de abordar temas de discusión distrital, como el cambio climático y el ordenamiento territorial, dio origen a este artículo de investigación pedagógica que se realizó en el IED Guillermo Cano Isaza de la localidad de Ciudad Bolívar, que convocó a la enseñanza entre pares de maestros y la creación de semilleros de investigación, con estudiantes, en torno a la actividad minera en el territorio, como excusa para la formación política, la construcción de conocimiento y la puesta en práctica de nuevas formas de transdisciplinaridad y dinámicas alternativas en la escuela.
Patient with anaemia and Rendu-osler-weber syndrome
Authors: Roa Colomo A , Caballero Mateos AM , García Márquez J 
Published: August 2021

Resumen

Varón de 66 años con Telangiectasia Hemorrágica Hereditaria tipo I que consulta por astenia intensa detectándose en analítica Hb 4 mg/dl; VCM 100,5%. El paciente no refiere síntomas de sangrado. En gastroscopia se visualizan múltiples malformaciones vasculares de tamaño variable y sin sangrado activo en esófago, estómago, siendo más numerosas en duodeno. En colonoscopia se distinguen varias angiodisplasias sin estigmas de sangrado reciente en ciego. El paciente recibe tratamiento de forma periódica con hierro intravenoso y transfusiones de concentrados de hematíes. La Telangiectasia Hemorrágica Hereditaria o síndrome de Rendu-Osler-Weber es una enfermedad hereditaria rara, de transmisión autosómica dominante, caracterizada por la aparición de malformaciones arterio-venosas o telangiectasias en cualquier localización del organismo. El síntoma más frecuente es la epistaxis asociada a anemia, seguida del sangrado gastrointestinal en el 13-30% de los pacientes. El tratamiento es de soporte, siendo importante tratar la anemia con hierro y transfusiones sanguíneas. Durante la endoscopia, cabe destacar la importancia de identificar el punto de sangrado activo y realizar sobre el mismo tratamiento de coagulación con plasma argón.
Ulcerated proctitis as the clinical presentation of lynphogranuloma venereum
Authors: Berdugo Hurtado F , Ruiz Rodríguez AJ , Roa Colomo A 
Published: August 2021

Resumen

Presentamos el caso de un varón de 57 años con clínica de proctalgia de un mes de evolución junto con despeños diarreicos, fiebre vespertina y tenesmo rectal. Ante sospecha clínica de posible colitis ulcerosa y que no podíamos descartar otras entidades diagnósticas; realizamos una colonoscopia con toma de muestras para microbiología y anatomía patológica, con hallazgo de proctitis crónica activa en relación con posible linfogranulóma venéreo. Sospecha que se confirmó con el estudio microbiológico de las muestras y el estudio serológico en sangre. Una vez iniciada la pauta antibiótica con doxaciclina, el paciente presentó una marcada mejoría clínica que se comprobó posteriormente en la colonoscopia de control con hallazgos de mucosa prácticamente sana.
Mapping Stellar Surfaces. II. An Interpretable Gaussian Process Model for Light Curves
Authors: Luger Rodrigo , Foreman-Mackey Daniel , Hedges Christina 
Published: August 2021

Abstract
The use of Gaussian processes (GPs) as models for astronomical time series data sets has recently become almost ubiquitous, given their ease of use and flexibility. In particular, GPs excel at marginalization over the stellar signal when the variability due to starspots is treated as a nuisance, as in exoplanet transit modeling. However, these effective models are less useful in cases where the starspot signal is of primary interest, since it is not obvious how the parameters of the GP relate to physical parameters like the spot size, contrast, and latitudinal distribution. Instead, it is common practice to explicitly model the effect of individual starspots on the light curve and attempt to infer their properties via optimization or posterior inference. Unfortunately, this process is ill-posed and often computationally intractable when applied to stars with more than a few spots and/or to ensembles of many stars. Here we derive a closed-form expression for a GP that describes the light curve of a rotating, evolving stellar surface conditioned on a given distribution of starspot sizes, contrasts, and latitudes. We demonstrate that this model is correctly calibrated, allowing one to robustly infer physical parameters of interest from one or more light curves, including the typical spot radii and latitudes. Our GP has far-ranging implications for understanding the variability and magnetic activity of stars from light curves and radial velocity measurements, as well as for modeling correlated noise in exoplanet searches. Our implementation is efficient, user-friendly, and open-source, available in the package starry_process.
Reimagining the Water Snowline
Authors: Bosman Arthur D. , Bergin Edwin A. 
Published: August 2021

Abstract
Water is a molecule that is tightly related to many facets of star and planet formation. Water’s abundance and distribution, especially the location of its snowline has thus been the subject of much study. While water is seen to be abundant in the inner region of protoplanetary disks in infrared spectroscopy, detections of water in the disk in the submillimeter are rare, with only one detection toward AS 205. Here we put the multitude of nondetections and the single detection into context of recent physicochemical models. We find that the 321.2257 GHz (102,9–93,6) line detection toward AS 205 is inconsistent with a normal inner disk temperature structure and that the observed line must be masing. Furthermore, the emitting area derived from the line width, together with published analyses on water in disks around T-Tauri stars implies that the water snowline in the disk surface is at the same location as the snowline in the midplane. We propose that this is caused by vertical mixing continuously sequestering water from the warm surface layers into the cold disk midplane.
The Discovery of Two LISA Sources within 0.5 kpc
Authors: Kilic Mukremin , Brown Warren R. , Bédard A. , Kosakowski Alekzander 
Published: August 2021

Abstract
We report the discovery of the brightest detached binary white dwarfs with periods less than an hour, which provide two new gravitational-wave verification binaries for the Laser Interferometer Space Antenna (LISA). The first one, SMSS J033816.16−813929.9 (hereafter J0338), is a 30.6 minute orbital period, g = 17.2 mag detached double white dwarf binary with a Gaia parallax measurement that places it at a distance of 533 pc. The observed radial velocity and photometric variability provide precise constraints on the system parameters. J0338 contains a 0.230 ± 0.015 M
⊙ white dwarf with a

0.38

−
0.03

+
0.05

M

⊙

companion at an inclination of 69° ± 9°. The second system, SDSS J063449.92+380352.2 (hereafter J0634), is a 26.5 minute orbital period, g = 17.0 mag detached double white dwarf binary at a distance of 435 pc. J0634 contains a

0.452

−
0.062

+
0.070

M

⊙

white dwarf with a

0.209

−
0.021

+
0.034

M

⊙

companion at an inclination of 37° ± 7°. The more massive white dwarf in J0634 is hotter than its companion, even though tidal dissipation is predicted to be relatively inefficient at such periods. This suggests that the more massive white dwarf formed last. J0338 and J0634 will be detected by LISA with a signal-to-noise ratio of 5 and 19, respectively, after four years. We identified these two systems based on their overluminosity and u-band photometry. Follow-up of u-band selected Gaia targets will likely yield additional LISA verification binaries.
Television advertising and development of dental caries in children aged 6 to 12 years
Authors: Doitchinova Liliya , Kirov Dimitar , Bakardjiev Petar , Nikolova Maria , Hristov Dimitar 
Published: August 2021

Introduction: Advertising today is increasingly seen to be targeting children as they can be easily persuaded. The influence on them is reinforced by children&rsquo;s difficulty in perceiving messages critically, in distinguishing the real from the imaginary, in their great confidence in messages from the media and popular characters and personalities, and in their inability to recognize risk and their propensity for imitation.
Aim: The aim of the study was to investigate the impact of television advertising on children&rsquo;s nutritional preferences and the intensity of dental caries in children aged 6 to 12 years.Materials and methods: The study included 277 children (158 boys and 119 girls) aged 6 to 12 years from different schools in Sofia. A survey was used to assess the nutritional preferences of these children who are under the influence of watching television commercials. The DMF (T+t) index introduced by Klein, Palmer &amp; Knutson (1938) was used to assess the intensity of dental caries. A correlation analysis was performed between the time spent watching TV and the development of dental caries.
Results: Many children buy on their own or ask their parents to buy advertised sweet candies, fizzy drinks and fruit juices, which are a risk factor for the development of dental caries. The results show that the longer they spend in front of the TV, the stronger the pronounced caries activity in children, supported by a statistically significant difference (p<0.001), Rho (277)=0.438.
Conclusions: The studied children aged 6 to 12 years have unhealthy dietary preferences for low molecular weight carbohydrate foods, increasing their oral risk profile. Prolonged standing in front of the TV screen correlated with an increase in the intensity of dental caries in half of the children.
Are patients willing to be informed on the risks and complications associated with the proposed therapy? A survey on informed consent
Authors: Dafni Aigli , Oikonomou Panagoula , Anagnostopoulos Konstantinos , Tsalikidis Christos , Dzhafer Nigyar , Tsaroucha Alexandra K. , Pitiakoudis Michail 
Published: August 2021

Introduction: Informed consent is essential to the patient-physician relationship. The paternalistic old-time approach used by physicians to achieve the optimal management is changing today; detailed medical information must be disclosed to the patients regarding their health problem.
Aim: The aim of this study was to highlight the value of informed consent in the context of medical practice as well as to emphasize its importance through the prism of human rights.
Materials and methods: A patient survey was conducted in two public and one private hospitals in Greece. Eighty-three inpatients from the Surgical Departments of Democritus University Hospital of Alexandroupolis (DUHA), Laikon University Hospital of Athens (LUHA) and a private hospital were included in the study. A questionnaire regarding patients&rsquo; attitude towards informed consent was distributed to patients prior to surgery.
Results: The majority of the patients (63.86% in DUHA, 59.38% in LUHA, and 78.95% in the private hospital) opted for full disclosure regarding the course and development of their condition.
Conclusion: Patients want to be informed about their treatment options and possible complications so that they can make decisions about their treatment after a comprehensive and understandable discussion.
Graves&#39; disease: pathophysiological aspects and considerations about using the chemometric analysis in the study of the disease
Authors: Koseva Pavlina M. , Kamenov Zdravko A. , Nikolova Mariana M. , Andreeva-Gateva Pavlina A. 
Published: August 2021

Graves&rsquo; disease is an immune system disorder that results in the overproduction of thyroid hormones (hyperthyroidism). Thyroid disorders are a societal problem of great public concern because of their high prevalence. This problem can affect the well-being and quality of life of patients. The predisposing factors leading to this disease are not yet fully established and are likely to be interconnected in a complex way.&nbsp;
Chemometric analysis allows for the detection of specific relationships between the medical parameter measurements obtained from the patients in an observation group, and the identification of patterns of similarity between these patients. It is not commonly used in clinical trials; however, it can provide reliable information which may help in creating more successful, individualised treatment strategies for established groups (patterns) of patients.
The aim of this review is to summarize the latest knowledge about the risk factors for Graves&rsquo; disease and considerations about using the chemometric analysis in the study of the disease.
Maritimité et paysage culturel maritime : les apports du modèle « Any-artefact »
Authors: Laubé Sylvain 
Published: August 2021

À partir de l’analyse des différentes définitions données dans le domaine de la géographie et du patrimoine (avec le terme « maritimité ») ou celui de l’archéologie maritime (avec le terme « maritimity »), une proposition plus précise est apportée, articulée avec les concepts de « paysage culturel maritime » et de « lieu de savoir ». Le couplage avec le méta-modèle « Any-artefact », développé à Brest depuis 2012 (dans le cadre de travaux de recherche interdisciplinaires en histoire des techniques et humanités numériques), nous a paru pertinent pour rendre opérante cette définition dans le domaine de l’histoire et du patrimoine des paysages culturels maritimes, dans le sens où « Any-artefact » est dédié à l’étude comparée des paysages culturels portuaires en considérant que leurs formations et leurs évolutions sont le résultat des activités humaines.
Quel matériel pour les radiodiffusions de l’Afrique subsaharienne française ?
Authors: Leyris Thomas 
Published: August 2021

Alors que la France développe un véritable réseau de radiodiffusion dans ses colonies d’Afrique subsaharienne au cours des années 1950, se pose la question de son équipement. Cet article défend l’idée que Pierre Schaeffer et les autres fondateurs de la Société de radiodiffusion de la France d’Outre-Mer (SORAFOM) ont délibérément détourné les normes techniques de la Radio-télévision française pour créer un équipement adapté et une acoustique différente dans les radios africaines. Cet article croise trois champs de recherche : l’histoire de l’innovation, les Sound studies et enfin l’histoire des médias en Afrique. Il révèle les raisons qui ont poussé à concevoir un matériel spécifique. Il propose d’éclairer les pratiques et les représentations qui ont guidé la réalisation de ces normes et de cet équipement mais aussi le résultat de ces efforts. Cet article est basé sur l’exploitation d’archives inédites du ministère de la Coopération et de témoignages rares d’anciens agents de la SORAFOM.
Les temporalités d’un grand projet technologique : Énergie atomique du Canada limitée et la trajectoire du réacteur MAPLE-X
Authors: Khelfaoui Mahdi 
Published: August 2021

À travers l’histoire du réacteur MAPLE-X, un projet nucléaire mené par l’entreprise publique Énergie atomique du Canada limitée, cet article s’intéresse aux temporalités qui rythment les trajectoires des grands projets technologiques (GPT). Longs, complexes, aux enjeux multiples et aux résultats incertains, les GPT sont soumis à différentes contraintes émanant de l’environnement interne et externe des organisations chargées de leur réalisation. Par conséquent, leur déroulement ne se réduit pas à l’écoulement d’un temps linéaire et homogène, mais est plutôt marqué par l’enchevêtrement de différentes temporalités, dont quatre sont identifiées dans le cas du projet MAPLE-X : technique, gestionnaire, réglementaire et politique. C’est dans l’articulation de ces temporalités et les tensions qu’elles exercent les unes sur les autres que se dessinent les trajectoires sinueuses des GPT.
Dramaturgies de l’inconstance
Authors: Bahier-Porte Christelle , Ailloud-Nicolas Catherine 
Published: August 2021

Loin de reproduire de pièce en pièce, comme cela lui a souvent été reproché, une éternelle surprise de l’amour, Marivaux a bâti une œuvre théâtrale protéiforme aux multiples contours. Tout regroupement inédit à l’intérieur du corpus théâtral fait apparaître de nouvelles lignes de force, de nouveaux liens avec les textes narratifs, qui mettent à mal le cliché de l’uniformité et de la répétition. Lorsque dialoguent La Double Inconstance, La Fausse suivante et La Dispute, la dramaturgie de l’inconstance se substitue à la « machine matrimoniale », donnant l’image d’un théâtre dans lequel relations humaines et sociales se tendent et se durcissent. Cette dramaturgie se nourrit de manipulation et de mensonge qui menacent la comédie et le comique, questionnent l’identité jusqu’au trouble, transforment les amours idéales en guerre des sexes ou en conquêtes financières.
Écriture du raffinement
Authors: Griveau-Genest Viviane 
Published: August 2021

Ce volume est consacré à l’oeuvre singulière de Marie de France, premier grand nom féminin de la littérature française de langue d’oïl. Une place importante est d’abord réservée au mystère qui entoure la personne de l’auteure, avec un point sur les récentes avancées en matière biographique à la lumière des théories modernes de l’auctorialité. Une attention particulière est accordée au rôle de la matière bretonne et du merveilleux dans les lais : sont mis en perspective les approches canoniques de la médiévistique littéraire et les apports récents de la mythologie comparée ou des postcolonial studies anglo saxonnes. Auteure féminine, Marie de France imposait enfin qu’une place soit faite à la question du genre, depuis la persona auctoriale jusqu’à la représentation littéraire en passant par l’écriture. Offrant un panorama de la critique, l’ouvrage entend fournir au lecteur contemporain les clés pour pouvoir apprécier la fraîcheur délicate d’une esthétique encore intacte par-delà les siècles.
Protein Phosphatase 4 Negatively Regulates the Immune Deficiency-NF-κB Pathway during the Drosophila Immune Response
Authors: Salem Wehbe Layale , Barakat Dana , Acker Adrian , El Khoury Rita , Reichhart Jean-Marc , Matt Nicolas , El Chamy Laure 
Published: August 2021

Abstract
The evolutionarily conserved immune deficiency (IMD) signaling pathway shields Drosophila against bacterial infections. It regulates the expression of antimicrobial peptides encoding genes through the activation of the NF-κB transcription factor Relish. Tight regulation of the signaling cascade ensures a balanced immune response, which is otherwise highly harmful. Several phosphorylation events mediate intracellular progression of the IMD pathway. However, signal termination by dephosphorylation remains largely elusive. Here, we identify the highly conserved protein phosphatase 4 (PP4) complex as a bona fide negative regulator of the IMD pathway. RNA interference–mediated gene silencing of PP4-19c, PP4R2, and Falafel, which encode the catalytic and regulatory subunits of the phosphatase complex, respectively, caused a marked upregulation of bacterial-induced antimicrobial peptide gene expression in both Drosophila melanogaster S2 cells and adult flies. Deregulated IMD signaling is associated with reduced lifespan of PP4-deficient flies in the absence of any infection. In contrast, flies overexpressing this phosphatase are highly sensitive to bacterial infections. Altogether, our results highlight an evolutionarily conserved function of PP4c in the regulation of NF-κB signaling from Drosophila to mammals.
Suppressive Monocytes Impair MAIT Cells Response via IL-10 in Patients with Severe COVID-19
Authors: Yang Qianting , Wen Yanling , Qi Furong , Gao Xiang , Chen Weixin , Xu Gang , Wei Cailing , Wang Haiyan , Tang Xian , Lin Jingyan , Zhao Juanjuan , Zhang Mingxia , Zhang Shuye , Zhang Zheng 
Published: August 2021

Abstract
Immune cell responses are strikingly altered in patients with severe coronavirus disease 2019 (COVID-19), but the immunoregulatory process in these individuals is not fully understood. In this study, 23 patients with mild and 22 patients with severe COVID-19 and 6 asymptomatic carriers of COVID-19 were enrolled, along with 44 healthy controls (HC). Peripheral immune cells in HC and patients with COVID-19 were comprehensively profiled using mass cytometry. We found that in patients with severe COVID-19, the number of HLA-DRlow/− monocytes was significantly increased, but that of mucosal-associated invariant T (MAIT) cells was greatly reduced. MAIT cells were highly activated but functionally impaired in response to Escherichia coli and IL-12/IL-18 stimulation in patients with severe COVID-19, especially those with microbial coinfection. Single-cell transcriptome analysis revealed that IFN-stimulated genes were significantly upregulated in peripheral MAIT cells and monocytes from patients with severe COVID-19. IFN-α pretreatment suppressed MAIT cells’ response to E. coli by triggering high levels of IL-10 production by HLA-DRlow/−–suppressive monocytes. Blocking IFN-α or IL-10 receptors rescued MAIT cell function in patients with severe COVID-19. Moreover, plasma from patients with severe COVID-19 inhibited HLA-DR expression by monocytes through IL-10. These data indicate a unique pattern of immune dysregulation in severe COVID-19, which is characterized by enrichment of suppressive HLA-DRlow/− monocytes associated with functional impairment of MAIT cells through the IFN/IL-10 pathway.
A cross-sectional study to assess the utilization pattern of maternal health services and associated factors in aspirational district of Haryana, India
Authors: Singh Abhishek , Palaniyandi Subramani , Palaniyandi Anitha , Gupta Vikas , Panika Ram Kumar , Mahore Rakesh Kumar , Goel Pawan Kumar 
Published: August 2021

Background:
In India mother related mortalities and morbidities are still significantly higher even after having various maternal program and schemes at regional and national level which reflects that such services are being under-utilized.

Aim:
The current study focused in assessing utilization pattern of maternal health services and associated factors in Nuh (Mewat).

Methods:
This present cross-sectional study was done for one year (2015-16) among mothers (15-49 years) under field practice area, PHC Taoru with minimum calculated sample as 645. The selection of participants was made using simple random sampling technique from available randomized list of villages. Data was collected by home-to-home visits using pretested, predesigned, standardized questionnaire and during analysis an association between variables was considered as significant if P < 0.05.

Results:
Out of 645 participants, 632 provided consent for inclusion into study. Any ANC and full ANC services was made by only 58.3% and 11.7% of participants respectively. More than half of the participants (52.7%) had suffered from pregnancy related complications. Variables such as lower age group, low decision-making capacity were significantly associated with not obtaining full ANC services (P < 0.05).

Conclusion:
In the present study major determinants of a women which influence utilization of maternal health care service includes their age, literacy status, parity, socioeconomic status and occupation. Such determinants shall be considered for upcoming intervention aiming to bring attitudinal changes and concurrently leading to improved and enhanced usage of maternal health care services.