bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amiodarone-induced organizing pneumonia mimicking COVID-19: a case report
Authors: Zizzo Gaetano , Caruso Stefano , Ricchiuti Elisabetta , Turato Roberto , Stefani Ilario , Mazzone Antonino 
Published: June 2021

Abstract
Background
Differential diagnosis of interstitial lung diseases (ILDs) during the COVID-19 pandemic is difficult, due to similarities in clinical and radiological presentation between COVID-19 and other ILDs on the one hand, and frequent false-negative swab results on the other. We describe a rare form of interstitial and organizing pneumonia resembling COVID-19, emphasizing some key aspects to focus on to get the right diagnosis and treat the patient properly.

Case presentation
A 76-year-old man presented with short breath and dry cough in the midst of the COVID-19 outbreak. He showed bilateral crackles and interstitial-alveolar opacities on X-ray, corresponding on computed tomography (CT) to extensive consolidations with air bronchograms, surrounded by ground glass opacities (GGO). Although his throat-and-nasopharyngeal swab tested negative, the picture was overall compatible with COVID-19. On the other hand, he showed subacute, rather than hyperacute, clinical onset; few and stable parenchymal consolidations, rather than patchy and rapidly evolving GGO; pleural and pericardial thickening, pleural effusion, and lymph node enlargement, usually absent in COVID-19; and peripheral eosinophilia, rather than lymphopenia, suggestive of hypersensitivity. In the past year, he had been taking amiodarone for a history of ventricular ectopic beats. CT scans, in fact, highlighted hyperattenuation areas suggestive of amiodarone pulmonary accumulation and toxicity. Bronchoalveolar lavage fluid (BALF) investigation confirmed the absence of coronavirus genome in the lower respiratory tract; conversely, high numbers of foamy macrophages, eosinophils, and cytotoxic T lymphocytes with low CD4/CD8 T-cell ratio were detected, confirming the hypothesis of amiodarone-induced cryptogenic organizing pneumonia. Timely discontinuation of amiodarone and initiation of steroid therapy led to resolution of respiratory symptoms, systemic inflammation, and radiographic opacities.

Conclusions
A comprehensive analysis of medical and pharmacological history, clinical onset, radiologic details, and peripheral and BALF cellularity, is required for a correct differential diagnosis and management of ILDs in the COVID-19 era.
Agricultural insurance access and acceptability: examining the case of smallholder farmers in Ghana
Authors: Ankrah Daniel Adu , Kwapong Nana Afranaa , Eghan Dennis , Adarkwah Francis , Boateng-Gyambiby Dominic 
Published: June 2021

Abstract
Background
Weather-related risks thwart agricultural productivity gains especially in the face of climate change. Agricultural insurance serves as a reliable risk mitigation instrument for coping with climate-related hazards. This notwithstanding, agricultural insurance penetration among smallholder farmers in the global south remains low. This study investigated the access and acceptability of agricultural insurance among smallholder food crop farmers in Ghana.

Method
The study employed a mixed-methods approach involving both quantitative and qualitative approaches. The study was carried out in the Northern, Volta and Western regions involving 7 communities in 5 districts. A total of 200 farmers were sampled through a multi-stage purposive sampling and interviewed. A cross-sectional survey involved 100 respondents under the quantitative approach whilst the qualitative study engaged additional 100 farmers.

Results
The results show that smallholder farmers’ access and acceptability of agricultural insurance is low (14%) and scarce but ironically considered useful by many (90%) as an effective tool to deal with agricultural risks. Inadequate knowledge about agricultural insurance products constituted the most stated reason (64%) for the scarce adoption rate, followed (23%) by the unavailability of insurance products in areas needed but absent. A few (5%) reported insurance to be expensive. Acceptability and accessibility of agricultural insurance are further influenced by gender, educational level, low knowledge, information asymmetry and wrong perception concerning agricultural insurance products. Sense of security and reduced impact of climate variabilities constituted important benefits guaranteed by agricultural insurance.

Conclusions
Agricultural insurance access and acceptability is constrained by limited knowledge of agricultural insurance products. It is recommended that more insurance companies be incentivized to augment already existing efforts by Ghana Agricultural Insurance Pool (GAIP) to enroll more smallholder farmers. The government can consider bundling existing insurance products with credit or inputs under the Planting for Food and Jobs Programme (PFJ) to improve uptake and accessibility of agricultural insurance.
The U-shaped crime recovery during COVID-19: evidence from national crime rates in Mexico
Authors: Balmori de la Miyar Jose Roberto , Hoehn-Velasco Lauren , Silverio-Murillo Adan 
Published: June 2021

AbstractThe existing empirical evidence suggests a reduction in aggregate crime as a consequence of the COVID-19 lockdown. However, what happens when lockdown measures are relaxed? This paper considers how the COVID-19 pandemic affects crime rates throughout Mexico when the stay-at-home orders end. We use national crime data from Mexico’s National Public Security System, which reports municipality-level rates on assault & battery, theft & property crime, fraud, drug crimes & extortion, and homicides. Our results show that the majority of crimes follow a U-shaped trend—when the lockdown ends—crimes rise back to pre-pandemic levels.
Using crime script analysis to elucidate the details of Amur tiger poaching in the Russian Far East
Authors: Skidmore Allison 
Published: June 2021

AbstractPoaching is the most direct threat to the persistence of Amur tigers. However, little empirical evidence exists about the modus operandi of the offenders associated with this wildlife crime. Crime science can aid conservation efforts by identifying the patterns and opportunity structures that facilitate poaching. By employing semi-structured interviews and participants observation with those directly involved in the poaching and trafficking of Amur tigers in the Russian Far East (RFE), this article utilizes crime script analysis to break down this criminal event into a process of sequential acts. By using this framework, it is possible account for the decisions made and actions taken by offenders before, during and after a tiger poaching event, with the goal of identifying weak points in the chain of actions to develop targeted intervention strategies. Findings indicate poaching is facilitated by the ability to acquire a firearm, presence of roads that enable access to remote forest regions, availability of specific types of tools/equipment, including heat vision googles or a spotlight and a 4 × 4 car, and a culture that fosters corruption. This crime script analysis elucidates possible intervention points, which are discussed alongside each step in the poaching process.
Defining the resilience of the human salivary microbiota by a 520-day longitudinal study in a confined environment: the Mars500 mission
Authors: Bacci Giovanni , Mengoni Alessio , Emiliani Giovanni , Chiellini Carolina , Cipriani Edoardo Giovanni , Bianconi Giovanna , Canganella Francesco , Fani Renato 
Published: June 2021

AbstractBackgroundThe human microbiota plays several roles in health and disease but is often difficult to determine which part is in intimate relationships with the host vs. the occasional presence. During the Mars500 mission, six crewmembers lived completely isolated from the outer world for 520 days following standardized diet regimes. The mission constitutes the first spaceflight simulation to Mars and was a unique experiment to determine, in a longitudinal study design, the composition and importance of the resident vs.a more variable microbiota—the fraction of the human microbiota that changes in time and according to environmental conditions—in humans.MethodsHere, we report the characterization of the salivary microbiota from 88 samples taken during and after Mars500 mission for a total of 720 days. Amplicon sequencing of the V3–V4 regions of 16S rRNA gene was performed, and results were analyzed monitoring the diversity of the microbiota while evaluating the effect of the three main variables present in the experimental system: time, diet, and individuality of each subject.ResultsResults showed statistically significant effects for either time, diet, and individuality of each subject. The main contribution came from the individuality of each subject, emphasizing salivary microbiota-personalized features, and an individual-based resilience of the microbiota.ConclusionsThe uniqueness of Mars500 mission, allowed to dampen the effect of environmental variables on salivary microbiota, highlighting its pronounced personalization even after sharing the same physical space for more than a year.
Single-cell chromatin accessibility landscape of human umbilical cord blood in trisomy 18 syndrome
Authors: Qiu Xiaofen , Yu Haiyan , Wu Hongwei , Hu Zhiyang , Zhou Jun , Lin Hua , Xue Wen , Cai Wanxia , Chen Jiejing , Yan Qiang , Dai Weier , Yang Ming , Tang Donge , Dai Yong 
Published: June 2021

Abstract
Background
Trisomy 18 syndrome (Edwards syndrome, ES) is a type of aneuploidy caused by the presence of an extra chromosome 18. Aneuploidy is the leading cause of early pregnancy loss, intellectual disability, and multiple congenital anomalies. The research of trisomy 18 is progressing slowly, and the molecular characteristics of the disease mechanism and phenotype are still largely unclear.

Results
In this study, we used the commercial Chromium platform (10× Genomics) to perform sc-ATAC-seq to measure chromatin accessibility in 11,611 single umbilical cord blood cells derived from one trisomy 18 syndrome patient and one healthy donor. We obtained 13 distinct major clusters of cells and identified them as 6 human umbilical cord blood mononuclear cell types using analysis tool. Compared with the NC group, the ES group had a lower ratio of T cells to NK cells, the ratio of monocytes/DC cell population did not change significantly, and the ratio of B cell nuclear progenitor and megakaryocyte erythroid cells was higher. The differential genes of ME-0 are enriched in Human T cell leukemia virus 1 infection pathway, and the differential peak genes of ME-1 are enriched in apopotosis pathway. We found that CCNB2 and MCM3 may be vital to the development of trisomy 18. CCNB2 and MCM3, which have been reported to be essential components of the cell cycle and chromatin.

Conclusions
We have identified 6 cell populations in cord blood. Disorder in megakaryocyte erythroid cells implicates trisomy 18 in perturbing fetal hematopoiesis. We identified a pathway in which the master differential regulatory pathway in the ME-0 cell population involves human T cell leukemia virus 1 infection, a pathway that is dysregulated in patients with trisomy 18 and which may increase the risk of leukemia in patients with trisomy 18. CCNB2 and MCM3 in progenitor may be vital to the development of trisomy 18. CCNB2 and MCM3, which have been reported to be essential components of the cell cycle and chromatin, may be related to chromosomal abnormalities in trisomy 18.
A 12-year follow-up of intestinal schistosomiasis in pre-school-aged children in Assoni Village, Eastern Senegal
Authors: N’Diaye Monique , Keita Boubacar Fodé , Danfakha Fodé , Keita Fili , Keita Gérald , Senghor Cheikh Sadibou , Diop Bocar , Diawara Lamine , Bessin François , Vernet Charlotte , Barbier Dominique , Dewavrin Patrick , Klotz Francis 
Published: June 2021

Abstract
Background
To monitor the prevalence of schistosomiasis in school-aged children (SAC), the National Bilharzia Control Program (PNLB) was set up by the Senegalese authorities; however, geographically isolated Bedik ethnic groups that did not benefit from this program were found to be heavily infected with Schistosoma mansoni. This observation led us to implement a new schistosomiasis control program in 2008 under the aegis of the non-governmental organization “Le Kaïcedrat” and in partnership with the PNLB/WHO to monitor the prevalence of schistosomiasis in this area. In the village of Assoni, where 100% of SAC were infected, analysis of the stools of pre-school-aged children (PSAC) showed that they were massively infected, so we decided to focus our program on them.

Methods
From 2008 to 2020, we (i) monitored the prevalence of S. mansoni in PSAC in Assoni using double-stool smear preparation, (ii) treated the infected PSAC with a standard dose of praziquantel 40 mg/kg, (iii) ran educational campaigns each year in the village, and (iv) built latrines to improve sanitation and reduce schistosomiasis transmission. Linear regression was used to examine the trend in the annual schistosomiasis prevalence and a two-sided of Chi-squared test was used to compare prevalence between the different age groups of PSAC.

Results
We observed an extremely high prevalence of schistosomiasis (78%) in PSAC before implementation of the program in 2008. Contamination occurred in very young children, as 64.3% of children under 2 years old were infected. Moreover, prevalence increased with age and reached 96.8% in children 4 to < 6 years old. Our annual interventions in Assoni Village raised awareness among villagers that water bodies were areas of significant infestation, allowed the building of 88 latrines and led to a decrease in prevalence in PSAC as only 11% of these children were infected in 2020.

Conclusion
Our study allowed Assoni to be the first village in Senegal to treat PSAC since 2014, but only on an individual basis. It also shows that schistosomiasis is difficult to eradicate and that multi-sectorial actions are required to keep its prevalence at a low level.

Graphic abstract
Dynamic mechanical and thermal properties of clear aligners after thermoforming and aging
Authors: Dalaie Kazem , Fatemi Seyyed Mostafa , Ghaffari Samin 
Published: June 2021

Abstract
Background
Based on the role of properties of aligner materials on their efficiency, we aimed to assess their thermomechanical properties after thermoforming and simulated aging.

Methods
In this experimental study, 96 samples of polyethylene terephthalate glycol (PETG) aligners (Duran and Erkodur) were prepared and divided to three groups: control (C), after thermoforming (T), after thermoforming and aging (TA). Thermoforming was done through 3D-printed molds, and aging was exerted by 200 thermal cycles after immersion in 37°C distilled water for 24h. Flexural modulus, hardness, glass transition temperature (Tg), elastic and viscous modulus, and loss factor were evaluated. Two-way ANOVA, T-independent, and Tukey HSD tests were done for statistical analysis and significance level was set to 0.05.

Results
In both materials, flexural modulus decreased significantly after thermoforming, 88% in Duran and 70% in Erkodur, but did not change significantly after aging. After thermoforming, hardness decreased significantly in both materials (22% in Duran and 7.6% in Erkodur). Dynamic Tg was significantly lower in T and TA in both materials. At all temperatures (25, 37, 55°C) in Duran, the elastic modulus difference was only significant between C and TA, but in Erkodur, it decreased significantly in T, and there was no significant change after aging. Viscous modulus and loss factor showed the same change patterns at all temperatures. In both materials, they increased after thermoforming, but did not change significantly after aging.

Conclusion
Thermoforming had more prominent role than aging in diminishing of thermomechanical properties. In general, Duran had greater thermomechanical stability than Erkodur.
Can preoperative liver MRI with gadoxetic acid help reduce open-close laparotomies for curative intent pancreatic cancer surgery?
Authors: Jhaveri Kartik S. , Babaei Jandaghi Ali , Thipphavong Seng , Espin-Garcia Osvaldo , Dodd Anna , Hutchinson Shawn , Reichman Trevor W. , Moulton Carol-Anne , McGilvary Ian D. , Gallinger Steven 
Published: June 2021

Abstract
Objectives
To evaluate gadoxetic acid-enhanced liver MRI (EOB-MRI) versus contrast-enhanced computed tomography (CECT) for preoperative detection of liver metastasis (LM) and reduction of open-close laparotomies for pancreatic ductal adenocarcinoma (PDAC).

Methods
Sixty-six patients with PDAC had undergone preoperative EOB-MRI and CECT. LM detection by EOB-MRI and CECT and their impact on surgical planning, open-close laparotomies were compared by clinical and radiology reports and retrospective analysis of imaging by two blinded independent readers. Histopathology or imaging follow-up was the reference standard. Statistical analysis was performed at patient and lesion levels with two-sided McNemar tests.

Results
EOB-MRI showed higher sensitivity versus CECT (71.7% [62.1-80.0] vs. 34% [25.0-43.8]; p = 0.009), comparable specificity (98.6%, [96.9-99.5] vs. 100%, [99.1-100], and higher AUROC (85.1%, [80.4-89.9] vs. 66.9%, [60.9-73.1]) for LM detection. An incremental 7.6% of patients were excluded from surgery with a potential reduction of up to 13.6% in futile open-close laparotomies due to LM detected on EOB-MRI only.

Conclusions
Preoperative EOB-MRI has superior diagnostic performance in detecting LM from PDAC. This better informs surgical eligibility with potential reduction of futile open-close laparotomies from attempted curative intent pancreatic cancer surgery.
Institutional inertia, local leadership turnover, and changes in the structure of fiscal expenditure
Authors: Yao Dongmin , Zhu Yongyi , Yu Kai 
Published: June 2021

AbstractTaking the perspective of local party and government leadership change and using L-kurtosis to analyze provincial panel data in China from 1996 to 2018, this article identifies the structural change pattern of fiscal expenditures. We find that economic construction, science, education, culture, and health expenditures conform to the punctuated equilibrium pattern, while public security expenditures conform to the gradualism pattern. For expenditures under the punctuated equilibrium pattern, the longer the current local leader’s tenure is, the greater the friction with institutional inertia, and the larger the deviation from the average expenditure structure during the previous local leader’s tenure; however, for expenditures under the gradualism pattern, the local leader factor does not have a significant effect. This article also discusses the motivations of new local leaders for adjusting their expenditure structure. In terms of the proportion of economic development expenditures, in targeting expenditures, new leaders are more likely to “strive for the upper ends of the country,” while the expenditures for science, education, culture, and health are targeted to “converge to the national average.”
Cerebral hemorrhage due to amyloid angiopathy that was difficult to differentiate from breast cancer metastasis: a case report
Authors: Uomori Toshitaka , Horimoto Yoshiya , Takanashi Masashi , Shikanai Ayana , Nakai Katsuya , Arakawa Astushi , Saito Mitsue 
Published: June 2021

Abstract
Background
Breast cancer patients are known to develop brain metastasis at a relatively high frequency. However, imaging findings of brain metastases vary, and it is sometimes very difficult to distinguish these from other tumorous lesions and non-neoplastic lesions, such as cerebral hemorrhage. Meanwhile, there are various causes of cerebral hemorrhage; a major one is cerebral amyloid angiopathy (CAA). With the advancement of imaging technology, CAA-related cerebral hemorrhage can be more precisely diagnosed with magnetic resonance imaging (MRI), but definitive diagnosis of CAA can only be made based on pathological assessment. Herein, we report a case of consciousness disorder appearing during adjuvant therapy for breast cancer. We initially considered that the patient’s cerebral hemorrhage was due to a metastatic tumor, but based on excisional biopsy, she was diagnosed with CAA.

Case presentation
A 73-year-old Japanese woman underwent curative surgery for left breast cancer. Her disease was hormone receptor-positive and human epidermal growth factor receptor 2 (HER2)-positive invasive ductal carcinoma (pStage IIB). While receiving adjuvant treatment, she developed disorientation, and emergent imaging revealed multiple cerebral hemorrhages. There was no apparent enhancement in the cerebral parenchyma on MRI, and differential diagnosis included hemorrhage due to a metastatic tumor, intravascular large B-cell lymphoma, CAA and thrombotic intracranial bleeding. After hospitalization, the bleeding lesion enlarged, resulting in cerebral hernia, and she needed emergency drainage surgery. The tissue surrounding the hemorrhage was pathologically assessed, and she was diagnosed with CAA. Although we initially suspected the lesion to be a metastatic tumor from breast cancer, there were no tumorous cells.

Conclusion
Atypical MRI findings made diagnosis difficult in this case, but it should be considered for differential diagnosis when multiple cerebral hemorrhages in elderly patients are observed, especially in cases with symptoms such as transient multifocal neurological deficits and dementia.
Techno-economic feasibility analysis of a 3-kW PV system installation in Nepal
Authors: Poudyal Ramhari , Loskot Pavel , Parajuli Ranjan 
Published: June 2021

AbstractThis study investigates the techno-economic feasibility of installing a 3-kilowatt-peak (kWp) photovoltaic (PV) system in Kathmandu, Nepal. The study also analyses the importance of scaling up the share of solar energy to contribute to the country's overall energy generation mix. The technical viability of the designed PV system is assessed using PVsyst and Meteonorm simulation software. The performance indicators adopted in our study are the electric energy output, performance ratio, and the economic returns including the levelised cost and the net present value of energy production. The key parameters used in simulations are site-specific meteorological data, solar irradiance, PV capacity factor, and the price of electricity. The achieved PV system efficiency and the performance ratio are 17% and 84%, respectively. The demand–supply gap has been estimated assuming the load profile of a typical household in Kathmandu under the enhanced use of electric appliances. Our results show that the 3-kWp PV system can generate 100% of electricity consumed by a typical residential household in Kathmandu. The calculated levelised cost of energy for the PV system considered is 0.06 $/kWh, and the corresponding rate of investment is 87%. The payback period is estimated to be 8.6 years. The installation of the designed solar PV system could save 10.33 tons of CO2 emission over its lifetime. Overall, the PV systems with 3 kWp capacity appear to be a viable solution to secure a sufficient amount of electricity for most households in Kathmandu city.