bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uso de filmes como estratégia no ensino de Bioética
Authors: Silva Davi Porfirio da , Vilela Diana Hadaça de Lima Araújo , Oliveira Fabianny Torres de , Comassetto Isabel , Santos Regina Maria dos 
Published: June 2021

O objetivo desse estudo é analisar a produção cientifica sobre o uso de filmes como estratégia no ensino de bioética. Trata-se de uma revisão integrativa de literatura, com resgate de estudos a partir das bases de dados LILACS, BDENF, MEDILINE e na Biblioteca Virtual SciELO, por meio dos DeCS/MeSH Bioethics, Teaching, Education, Nursing, Instructional Film and Video, Motion Pictures e as palavras-chave Movies e Cinema. Foram selecionados oito estudos, distribuídos uniformemente nos últimos 10 anos, com texto em inglês, espanhol e português, resgatados a partir das bases de dados LILACS e MEDLINE, todos classificados no nível de evidência IV. Nesse contexto, os estudos resgatados nessa revisão apontam resultados positivos quanto ao uso de filmes no ensino de bioética, afirmando a importância da incorporação dessa estratégia nas práticas pedagógicas dos cursos de saúde. Houve massificação na concordância do uso dessa ferramenta para discussão de ideias morais e filosóficas novas ou complexas, que impactam diretamente nas questões da prática clínica no âmbito dos profissionais da saúde. Porém, a literatura ressalta que essa estratégia não deve ser usada como entretenimento despretensioso e sem compromisso.
Pembuatan Pestisida Nabati dan Pupuk Organik dari Kotoran Sapi Pada Kelompok Tani Kelurahan Klamalu Kabupaten Sorong
Authors: Ali Akhmad , Ponisri Ponisri , Ogonei Adrianus , Sangkek Febelina 
Published: June 2021

Produk pertanian yang dilakukan oleh masyarakat selama ini masih menggunakan pestisida dan pupuk kimia sehingga hal ini tentunya akan sangat membahayakan bagi kesehatan, karena tanaman atau sayuran yang dikonsumsi tentunya masih mengandung bahan kimia. Untuk menggurangi penggunaan bahan-bahan kimia tersebut maka perlu adanya pestisida nabati dan penggunaan pupuk organik/kompos. Dimana pestisida nabati ini dapat dibuat yang bahan aktifnya berasal dari tanaman atau tumbuhan dan bahan organik lainya yang berkhasiat mengendalikan serangan hama pada tanaman. Pestisida ini tidak meninggalkan residu yang berbahaya pada tanaman maupun lingkungan serta dapat di buat dengan mudah menggunakan bahan yang murah dan peralatan yang sederhana.Â Sedangkan pupuk kompos ini dapat berasal dari bahan-bahan organik dan kotoran hewan yang bermanfaat untuk menyediakan unsur hara mikro bagi tanaman, mengemburkan tanah dan menyuburkan tanah-tanah tandus
Pemanfaatan Tumbuhan Berkhasiat Obat Berbasis Pengetahuan Masyarakat Lokal Kampung Nanggouw Distrik Sausapor Kabupaten Tambrauw
Authors: Gafur Muzna Ardin  Abdul 
Published: June 2021

Kampung Nanggouw Distrik Sausapor Kabupaten Tambrauw merupakan perkampungan penduduk asli suku Abun, terletak di wilayah Pesisir Dsitrik Sausapor Kabupaten Tambrauw.Â Kampung ini berjarak 108 km dari Kota Sorong, dapat ditempuh dengan perjalanan darat selama lebih kurang 5 jam menggunakan kenderaan roda empat.Â Permasalahan utama di kampung ini adalah rendahnya tingkatÂ kesehatan masyarakat.Â Penyakit yang umumnya menyerang adalah malaria, infeksi paru-paru dan penyakit kulit.Â Fasilitas kesehatan dan pendukungnya masih sangat kurang, di kampung ini tidak terdapat puskesmas.Â Untuk berobat, masyarakat harus ke Ibukota Distrik atau ke Ibukota kabupaten.Â Â Salah satu alternatif penyelesaian masalah kesehatan di Kampung Nanggouw adalah dengan cara membekali masyarakat agar dapat mengatasi permasalahan kesehatan secara mandiri.Â Â Kampung dengan kekayaan sumber daya alam yang besarÂ iniÂ Â Â memiliki potensi tumbuhan obat yang cukup banyak, akan tetapi informasi dan pengetahuan masyarakat terhadap mafaat tumbuhan obat itu masih sangat kurang.Â Oleh sebab itu dianggap penting untuk memberikan informasi, pengetahuan, dan pengalaman tentang jenis-jenis tumbuhan berkhasiat obat, cara pengolahan dan penyiapannya dalam bentuk siap pakai.Â Kegiatan pengabdian ini dilakukan dalam bentuk sosialisai dan penyuluhan kepada masyarakat terutama ibu-ibu, pemuda dan remaja.
GnRHa/Stanozolol Combined Therapy Maintains Normal Bone Growth in Central Precocious Puberty
Authors: Zhu Shunye , Long Lingli , Hu Yue , Tuo Ying , Li Yubin , Yu Zhenhua 
Published: June 2021

BackgroundGonadotropin-releasing hormone agonist (GnRHa) is the gold standard in the treatment of Central Precocious Puberty (CPP) with progressive puberty and accelerative growth. However, GnRHa treatment is reported to result in growth deceleration and prevents growth plate development which leads to a reduction in height velocity. Stanozolol (ST) has been used to stimulate growth in patients with delayed growth and puberty, nevertheless, the effects and mechanisms of ST on CPP with GnRHa treatment are currently unclear.Methods and ResultsIn the current study, we recorded the following vital observations that provided insights into ST induced chondrogenic differentiation and the maintenance of normal growth plate development: (1) ST efficiently prevented growth deceleration and maintained normal growth plate development in rats undergoing GnRHa treatment; (2) ST suppressed the inhibitory effect of GnRHa to promote chondrogenic differentiation; (3) ST induced chondrogenic differentiation through the activation of the JNK/c-Jun/Sox9 signaling pathway; (4) ST promoted chondrogenic differentiation and growth plate development through the JNK/Sox9 signaling pathway in vivo.ConclusionsST mitigated the inhibitory effects of GnRHa and promoted growth plate development in rats. ST induced the differentiation of chondrocytes and maintained normal growth plate development through the activation of JNK/c-Jun/Sox9 signaling. These novel findings indicated that ST could be a potential agent for maintaining normal bone growth in cases of CPP undergoing GnRHa treatment.
Whole Transcriptome Data Analysis Reveals Prognostic Signature Genes for Overall Survival Prediction in Diffuse Large B Cell Lymphoma
Authors: Pan Mengmeng , Yang Pingping , Wang Fangce , Luo Xiu , Li Bing , Ding Yi , Lu Huina , Dong Yan , Zhang Wenjun , Xiu Bing , Liang Aibin 
Published: June 2021

BackgroundWith the improvement of clinical treatment outcomes in diffuse large B cell lymphoma (DLBCL), the high rate of relapse in DLBCL patients is still an established barrier, as the therapeutic strategy selection based on potential targets remains unsatisfactory. Therefore, there is an urgent need in further exploration of prognostic biomarkers so as to improve the prognosis of DLBCL.MethodsThe univariable and multivariable Cox regression models were employed to screen out gene signatures for DLBCL overall survival (OS) prediction. The differential expression analysis was used to identify representative genes in high-risk and low-risk groups, respectively, where student t test and fold change were implemented. The functional difference between the high-risk and low-risk groups was identified by the gene set enrichment analysis.ResultsWe conducted a systematic data analysis to screen the candidate genes significantly associated with OS of DLBCL in three NCBI Gene Expression Omnibus (GEO) datasets. To construct a prognostic model, five genes (CEBPA, CYP27A1, LST1, MREG, and TARP) were then screened and tested using the multivariable Cox model and the stepwise regression method. Kaplan–Meier curve confirmed the good predictive performance of this five-gene Cox model. Thereafter, the prognostic model and the expression levels of the five genes were validated by means of an independent dataset. High expression levels of these five genes were significantly associated with favorable prognosis in DLBCL, both in training and validation datasets. Additionally, further analysis revealed the independent value and superiority of this prognostic model in risk prediction. Functional enrichment analysis revealed some vital pathways responsible for unfavorable outcome and potential therapeutic targets in DLBCL.ConclusionWe developed a five-gene Cox model for the clinical outcome prediction of DLBCL patients. Meanwhile, potential drug selection using this model can help clinicians to improve the clinical practice for the benefit of patients.
Instrumental Heterogeneity in Sex-Specific Two-Sample Mendelian Randomization: Empirical Results From the Relationship Between Anthropometric Traits and Breast/Prostate Cancer
Authors: Gao Yixin , Zhang Jinhui , Zhao Huashuo , Guan Fengjun , Zeng Ping 
Published: June 2021

BackgroundIn two-sample Mendelian randomization (MR) studies, sex instrumental heterogeneity is an important problem needed to address carefully, which however is often overlooked and may lead to misleading causal inference.MethodsWe first employed cross-trait linkage disequilibrium score regression (LDSC), Pearson’s correlation analysis, and the Cochran’s Q test to examine sex genetic similarity and heterogeneity in instrumental variables (IVs) of exposures. Simulation was further performed to explore the influence of sex instrumental heterogeneity on causal effect estimation in sex-specific two-sample MR analyses. Furthermore, we chose breast/prostate cancer as outcome and four anthropometric traits as exposures as an illustrative example to illustrate the importance of taking sex heterogeneity of instruments into account in MR studies.ResultsThe simulation definitively demonstrated that sex-combined IVs can lead to biased causal effect estimates in sex-specific two-sample MR studies. In our real applications, both LDSC and Pearson’s correlation analyses showed high genetic correlation between sex-combined and sex-specific IVs of the four anthropometric traits, while nearly all the correlation coefficients were larger than zero but less than one. The Cochran’s Q test also displayed sex heterogeneity for some instruments. When applying sex-specific instruments, significant discrepancies in the magnitude of estimated causal effects were detected for body mass index (BMI) on breast cancer (P = 1.63E-6), for hip circumference (HIP) on breast cancer (P = 1.25E-20), and for waist circumference (WC) on prostate cancer (P = 0.007) compared with those generated with sex-combined instruments.ConclusionOur study reveals that the sex instrumental heterogeneity has non-ignorable impact on sex-specific two-sample MR studies and the causal effects of anthropometric traits on breast/prostate cancer would be biased if sex-combined IVs are incorrectly employed.
The Gut and Blood Microbiome in IgA Nephropathy and Healthy Controls
Authors: Shah Neal B. , Nigwekar Sagar U. , Kalim Sahir , Lelouvier Benjamin , Servant Florence , Dalal Monika , Krinsky Scott , Fasano Alessio , Tolkoff-Rubin Nina , Allegretti Andrew S. 
Published: June 2021

Abstract

Key Points

A higher microbiome load, possibly originating from different body sites, may be playing a pathogenic role in IgA nephropathy.Several microbiome taxonomic differences between patients with IgA nephropathy and healthy controls are observed in blood and stool.Striking differences between the blood and gut microbiome confirm that the blood microbiome does not directly reflect the gut microbiome.

Background
IgA nephropathy (IgAN) has been associated with gut dysbiosis, intestinal membrane disruption, and translocation of bacteria into blood. Our study aimed to understand the association of gut and blood microbiomes in patients with IgAN in relation to healthy controls.

Methods
We conducted a case-control study with 20 patients with progressive IgAN, matched with 20 healthy controls, and analyzed bacterial DNA quantitatively in blood using 16S PCR and qualitatively in blood and stool using 16S metagenomic sequencing. We conducted between-group comparisons as well as comparisons between the blood and gut microbiomes.

Results
Higher median 16S bacterial DNA in blood was found in the IgAN group compared with the healthy controls group (7410 versus 6030 16S rDNA copies/μl blood, P=0.04). α- and β-Diversity in both blood and stool was largely similar between the IgAN and healthy groups. In patients with IgAN, in comparison with healthy controls, we observed higher proportions of the class Coriobacteriia and species of the genera Legionella, Enhydrobacter, and Parabacteroides in blood, and species of the genera Bacteroides, Escherichia-Shigella, and some Ruminococcus in stool. Taxa distribution were markedly different between the blood and stool samples of each subject in both IgAN and healthy groups, without any significant correlation between corresponding gut and blood phyla.

Conclusions
Important bacterial taxonomic differences, quantitatively in blood and qualitatively in both blood and stool samples, that were detected between IgAN and healthy groups warrant further investigation into their roles in the pathogenesis of IgAN. Although gut bacterial translocation into blood may be one of the potential sources of the blood microbiome, marked taxonomic differences between gut and blood samples in each subject in both groups confirms that the blood microbiome does not directly reflect the gut microbiome. Further research is needed into other possible sites of origin and internal regulation of the blood microbiome.
From Italy to the USA: Cleveland Italians, Their Heritage and Traditions
Authors: Mátyás Dénes 
Published: June 2021

One would be hard-pressed to deny the influence Italians have had on the United States of America and on the very fabric of American cultural life. Not only are metropolises like New York City and Chicago with their populations in the millions home to significant Italian communities and neighborhoods but so are cities with several hundred thousand inhabitants like Boston, Baltimore, Syracuse, St. Louis, or Cleveland. The present paper intends to focus on Italians in Cleveland, Ohio, that undoubtedly constitute an organic and significant part of the city’s population. It aims to offer an insight into the formation of the Italian neighborhoods, from the first waves of Italian immigrants in the 19th century, and the opportunities of second-, third-, or nth-generation Italians to tend to their common Italian roots as well as to preserve their customs and traditions from the old country through a wide array of Italian cultural events, the city’s Italian community hubs and memorial sites, or the local Italian-American media
POLA KONSUMSI DAN SANITASI LINGKUNGAN BALITA STUNTING DI POLEWALI MANDAR
Authors: Afriani Afriani , Patmawati Patmawati 
Published: June 2021

This study aims to analyze the pattern of consumption and environmental sanitation in stunting children in the Wonomulyo Polewali Mandar district. Method The study design used was analytic observational. The total sample was 101 toddlers aged 6-36 months, using simple random sampling method. The determination of nutritional status was processed using the WHO AntroPlus 2010 including the Semi Quantitative Food Frequency Questionnaire and an environmental sanitation questionnaire.
Results: The frequency of frequent consumption of carbohydrates 79.21%, the frequency of animal protein (48.52%), vegetable protein (41.58%), fruit (46.58%), and beverages (43.6%). ), snacks (47.52%), and rare frequency of vegetables (44.54%). The average intake of energy (773.87 kcal), protein (18.19 gr), calcium (471.61 mg), and iron (8.15 mg). There was no significant relationship with the adequacy of nutrients for energy (p = 0.422), protein (p = 0.428), calcium (p = 0.075) and iron parameters had a significant relationship (p = 0.049). The results of environmental quality measurement obtained data on toddlers with short and very short nutritional status in the healthy environmental sanitation category as much as 18 (17.8%) and toddlers with short and very short nutritional status in the category of unhealthy environmental sanitation by 83 (82.2%). So that the results of the sig value test (2-sided) of 0.951> 0.05, it can be concluded that there is no relationship between nutritional status and unhealthy sanitary conditions. Conclusion: Iron adequacy is related to stunting status, while environmental sanitation quality is not related to stunting status.
Perencanaan Arsitektur Organisasi Untuk Mendukung Pengembangan Sistem Informasi Perguruan Tinggi
Authors: Mulyana Ade , Cahyadi Septian , Sukamto Anton 
Published: June 2021

Strategies and policies in a profit-oriented organization have a social mission (public service) that prioritizes customer service. The development of information systems and information technology will have an impact on increasingly competitive competition, this also applies in the world of education, especially for higher education institutions that are managed by the community (private), requiring managers to build and develop information systems to help business activities, achieve organizational goals. and services for stakeholders. Enterprise Architecture Planning (EAP) as a method or frame of reference for building an information architecture. EAP is an architectural planning method that is oriented to business needs which consist of data architecture, applications, and technology as well as an implementation plan of the architecture that has been created to support business activities for the achievement of an organization's mission.
Keywords: Enterprise Architecture, information architecture, business activities.
Rancang Bangun Sistem Informasi Kepegawaian Berbasis Web di STIE Kesatuan
Authors: Hermawan Yanto , Mulyana Ade , Rizky I. Nurul Fadillah 
Published: June 2021

STIE Kesatuan personnel information system is a problem of special concern in IBI Kesatuan HRD. This is with the ease and effectiveness in processing employee data such as employee data entry, editing employee data, searching employee data, reporting employee data either on screen or printed on paper. There are still many STIE Kesatuan who have not filled in data on manual paper, such as employees who have to fill out a leave form and wait for approval. So to overcome this we need a personnel information system that is better than the previous system, for now the employee information is only from Microsoft Excel and manual data. This study uses a system design implemented with the Diagram Unified Modeling Language (UML). The expected end result is that the employee web-based information system can solve system problems that run more optimally in the employee data entry process. With this research, it is hoped that it can help IBI Kesatuan, especially HRD, to develop a management information system. Keywords: Information Systems, UML Diagram.
Limiting Behavior of Asteroid Obliquity and Spin Using a Semi-analytic Thermal Model of the YORP Effect
Authors: Golubov Oleksiy , Unukovych Vladyslav , Scheeres Daniel J. 
Published: June 2021

Abstract
The Yarkovsky–O’Keefe–Radzievskii–Paddack (YORP) effect governs the spin evolution of small asteroids. The axial component of YORP, which alters the rotation rate of the asteroid, is mostly independent of its thermal inertia, while the obliquity component is very sensitive to the thermal model of the asteroid. Here, we develop a semi-analytic theory for the obliquity component of YORP. We integrate an approximate thermal model over the surface of an asteroid, and find an analytic expression for the obliquity component in terms of two YORP coefficients. This approach allows us to investigate the overall evolution of asteroid rotation state, and to generalize the results previously obtained in the case of zero thermal inertia. The proposed theory also explains how a nonzero obliquity component of YORP originates even for a symmetric asteroid, due to its finite thermal inertia. In many cases, this causes equatorial planes of asteroids to align with their orbital planes. The studied nontrivial behavior of YORP as a function of thermal model allows for a new kind of rotational equilibria, which can have important evolutionary consequences for asteroids.
Globular Cluster Systems of Massive Compact Elliptical Galaxies in the Local Universe: Evidence for Relic Red Nuggets?
Authors: Kang Jisu , Lee Myung Gyoon 
Published: June 2021

Abstract
Nearby massive compact elliptical galaxies (MCEGs) are strong candidates for relic galaxies (i.e., local analogs of red nuggets at high redshifts). It is expected that the globular cluster (GC) systems of relic galaxies are dominated by red (metal-rich) GCs. NGC 1277 is known as a unique example of such a galaxy in the previous study. In this study, we search for GCs in 12 nearby MCEGs at distances of ≲100 Mpc from the Hubble Space Telescope/Wide Field Camera 3 F814W(I
814)/F160W(H
160) archival images. We find that most of these MCEGs host a rich population of GCs with a color range of

. The fractions of their red GCs range from f
RGC = 0.2 to 0.7 with a mean of f
RGC = 0.48 ± 0.14. We divide the MCEG sample into two groups: one in clusters and the other in groups/fields. The mean red GC fraction of the cluster MCEGs is 0.60 ± 0.06, which is 0.2 larger than the value of the group/field MCEGs, 0.40 ± 0.10. The value for the cluster MCEGs is ∼0.3 larger than the mean value of giant early-type galaxies with similar stellar mass in the Virgo Cluster (f
RGC = 0.33 ± 0.13). Our results show that most of the MCEGs in our sample are indeed relic galaxies. This further implies that a majority of the red GCs in MCEGs are formed early in massive galaxies and that most MCEGs in the local universe have rarely undergone mergers after they became red nuggets about 10 Gyr ago.
The MOSDEF Survey: The Evolution of the Mass–Metallicity Relation from z = 0 to z ∼ 3.3*
Authors: Sanders Ryan L. , Shapley Alice E. , Jones Tucker , Reddy Naveen A. , Kriek Mariska , Siana Brian , Coil Alison L. , Mobasher Bahram , Shivaei Irene , Davé Romeel , Azadi Mojegan , Price Sedona H. , Leung Gene , Freeman William R. , Fetherolf Tara , de Groot Laura , Zick Tom , Barro Guillermo 
Published: June 2021

Abstract
We investigate the evolution of galaxy gas-phase metallicity (O/H) over the range z = 0–3.3 using samples of ∼300 galaxies at z ∼ 2.3 and ∼150 galaxies at z ∼ 3.3 from the MOSDEF survey. This analysis crucially utilizes different metallicity calibrations at z ∼ 0 and z > 1 to account for evolving interstellar medium (ISM) conditions. We find significant correlations between O/H and stellar mass (M
*) at z ∼ 2.3 and z ∼ 3.3. The low-mass power-law slope of the mass–metallicity relation (MZR) is remarkably invariant over z = 0–3.3, such that O/H ∝

at all redshifts in this range. At fixed M
*, O/H decreases with increasing redshift as dlog(O/H)/dz = −0.11 ± 0.02. We find no evidence that the fundamental metallicity relation between M
*, O/H, and star formation rate evolves out to z ∼ 3.3. We employ analytic chemical evolution models to place constraints on the mass and metal loading factors of galactic outflows. The efficiency of metal removal increases toward lower M
* at fixed redshift and toward higher redshift at fixed M
*. These models suggest that the slope of the MZR is primarily set by the scaling of the outflow metal loading factor with M
*, not by the change in gas fraction as a function of M
*. The evolution toward lower O/H at fixed M
* with increasing redshift is driven by both higher gas fraction (leading to stronger dilution of ISM metals) and higher metal removal efficiency. These results suggest that the processes governing the smooth baryonic growth of galaxies via gas flows and star formation hold in the same form over at least the past 12 Gyr.