bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resumption of the treatment of non‐COVID‐19 gynecologic patients after lifting lockdown: Triage and infection prevention experiences from Wuhan
Authors: Dong Weihong , Gao Rui , Cai Jing , Yang Shouhua , Guo Jianfeng , Zhao Jing , Wang Zehua , Cai Liqiong 
Published: July 2021

AbstractAimTo share our experiences of resuming the treatments for gynecologic patients after lifting the lockdown in a hotspot area for the Coronavirus Disease 2019 (COVID‐19) pandemic.MethodsThe triage process used to resume medical activities for gynecologic patients at the Wuhan Union Hospital after a 76‐day lockdown of the city is described, and its effectiveness in preventing COVID‐19 nosocomial transmission is shown.ResultsNonemergency patients were pretriaged based on their contact history and body temperature at an outpatient clinic, and negative COVID‐19 screening test results were required for admission to the buffering rooms at the gynecologic department. The buffering lasted at least 3 days for symptom monitoring, and a second round of COVID‐19 testing was required before patients could be transferred to the regular gynecologic wards. For patients who needed emergency surgery, the first screening was completed at the isolation wards after surgery, followed by buffering at the gynecologic department. We received 19 298 outpatient visits, admitted 326 patients, and performed 223 operations in the first 2 months after the lockdown was lifted. No COVID‐19 cases occurred in the hospitalized patients, while the proportion of potentially high‐risk patients with cancer and severe anemia was increased in comparison to that observed during the same period in 2019 and the first 2 months of 2020 before the lockdown.ConclusionsWe provide an effective triage system with buffering at two levels to guarantee safe and timely treatment for non‐COVID‐19 gynecologic patients in the postlockdown phase.
Twenty‐four‐week interim outcomes of bedaquiline‐containing regimens in treatment of adolescents with rifampicin‐resistant tuberculosis: A retrospective cohort study in China
Authors: Wu Hao‐Yu , Tian Yao , Wang Xiao‐Dan , Sun Ji‐Si , Fan Li‐Chao , Chen Mo‐Xin , Li Ran , Chen Yu 
Published: July 2021

AimTo evaluate the 24‐week interim outcomes of bedaquiline‐containing regimens in the treatment of adolescents with rifampicin‐resistant tuberculosis (RR‐TB) in China.MethodsAdolescents with RR‐TB from two hospitals were included in this retrospective study. All patients received the longer regimen containing bedaquiline. Sputum culture, chest computed tomography, blood tests and electrocardiography were performed regularly, and the outcomes after 24 weeks of treatment were reported.ResultsFour male and six female adolescents aged 11 to 17 years old were included. Among them, four (40.0%), four (40.0%) and two (20.0%) were confirmed to have RR‐TB, multidrug‐resistant TB and extensively drug‐resistant TB, respectively. The most common companion drugs included linezolid (100.0%), cycloserine (90.0%), pyrazinamide (80.0%), moxifloxacin (50.0%) and levofloxacin (40.0%). Culture conversion rates of 80.0%, 100.0% and 100.0% were observed at weeks 2, 4 and 24, respectively. The mean maximum drug concentration of bedaquiline at weeks 2, 12 and 24 was 3.29 ± 0.66, 1.78 ± 0.81 and 1.93 ± 0.74 μg/mL, respectively. Six adverse events including leukopenia (50.0%), Fridericia‐corrected QT (QTcF) interval prolongation (16.7%), anaemia (16.7%) and peripheral neuropathy (16.7%) were observed in five (50.0%) patients. No patient discontinued bedaquiline owing to QTcF interval prolongation. Meanwhile, no deaths, reversions or serious adverse events were reported during 24 weeks of treatment.ConclusionA longer regimen containing bedaquiline was effective and well tolerated in Chinese adolescents with RR‐TB. The combination of bedaquiline and linezolid may be a favourable choice for this population.
The impact of maternal post‐partum depressive symptoms on child diet at 18 months
Authors: Opie Rachelle S. , Zheng Miaobing , Torres Susan , Campbell Karen 
Published: July 2021

AbstractPost‐partum depression (PPD) is a serious mental health problem, which can impair maternal behaviours and adversely affect the cognitive, emotional and behavioural development of children. This study aims to explore the impact of maternal depressive symptoms at 3 months post‐partum (baseline) on child diet at 18 months of age (follow‐up). This study used longitudinal data from 263 first‐time mothers from the Melbourne Infant Feeding, Activity and Nutrition Trial (InFANT) Extend. Women self‐reported depressive symptoms (10‐item Center for Epidemiological Studies Depression Scale [CES‐D]) and child diet (fruits, vegetables and discretionary foods). Multiple linear regression analyses were used to explore the relationship between maternal depressive symptoms at baseline and child fruit and vegetable intake and discretionary food intake (g day−1) at follow‐up. Baseline maternal depressive symptoms were associated with higher childhood consumption of discretionary foods at 18 months of age (β = 0.45, 95% confidence interval [CI] 0.03 to 0.87, P = 0.034 [adjusted]). There was no evidence of association for maternal depressive symptoms and child intake of fruits and vegetables. Further longitudinal studies are warranted to confirm these findings, with the hope of translating this knowledge into optimal clinic care and improved physical and mental health for mother and child.
Resistance, resilience, and functional redundancy of freshwater bacterioplankton communities facing a gradient of agricultural stressors in a mesocosm experiment
Authors: Barbosa da Costa Naíla , Fugère Vincent , Hébert Marie‐Pier , Xu Charles C.Y. , Barrett Rowan D.H. , Beisner Beatrix E. , Bell Graham , Yargeau Viviane , Fussmann Gregor F. , Gonzalez Andrew , Shapiro B. Jesse 
Published: July 2021

AbstractAgricultural pollution with fertilizers and pesticides is a common disturbance to freshwater biodiversity. Bacterioplankton communities are at the base of aquatic food webs, but their responses to these potentially interacting stressors are rarely explored. To test the extent of resistance and resilience in bacterioplankton communities faced with agricultural stressors, we exposed freshwater mesocosms to single and combined gradients of two commonly used pesticides: the herbicide glyphosate (0–15 mg/L) and the neonicotinoid insecticide imidacloprid (0–60 μg/L), in high or low nutrient backgrounds. Over the 43‐day experiment, we tracked variation in bacterial density with flow cytometry, carbon substrate use with Biolog EcoPlates, and taxonomic diversity and composition with environmental 16S rRNA gene amplicon sequencing. We show that only glyphosate (at the highest dose, 15 mg/L), but not imidacloprid, nutrients, or their interactions measurably changed community structure, favouring members of the Proteobacteria including the genus Agrobacterium. However, no change in carbon substrate use was detected throughout, suggesting functional redundancy despite taxonomic changes. We further show that communities are resilient at broad, but not fine taxonomic levels: 24 days after glyphosate application the precise amplicon sequence variants do not return, and tend to be replaced by phylogenetically close taxa. We conclude that high doses of glyphosate – but still within commonly acceptable regulatory guidelines – alter freshwater bacterioplankton by favouring a subset of higher taxonomic units (i.e., genus to phylum) that transiently thrive in the presence of glyphosate. Longer‐term impacts of glyphosate at finer taxonomic resolution merit further investigation.
Disagreement without belief
Authors: Shemmer Yonatan , Bex‐Priestley Graham 
Published: July 2021

AbstractWhen theorising about disagreement, it is tempting to begin with a person's belief thatpand ask what mental state one must have in order to disagree with it. This is the wrong way to go; the paper argues that people may also disagree with attitudes that are not beliefs. It then examines whether several existing theories of disagreement can account for this phenomenon. It argues that its own normative theory of disagreement gives the best account, and so, given that there is good reason to believe disagreement without belief is possible, there is good reason to think that disagreement itself is normative.
Traditional medicines prescribed for prevention of COVID‐19: Use with caution
Authors: Parthasarathy Rajeevalochana , Mathew Milly , Koshy Priyanka , Babu Madhusri , Abraham Georgi 
Published: July 2021

AbstractAcute interstitial nephritis can result due to exposure to any medication, toxins, infections or malignancy. In the midst of this Coronavirus (COVID‐19) pandemic, there has been a race for finding remedies to prevent the spread of and control the complications due to Severe Acute Respiratory Syndrome Coronavirus 2. Certain Indian medicinal herb concoctions like kabasura kudineer and nilavembu kudineer are being widely publicized to boost immunity and reduce the risk of developing COVID‐19. Little knowledge exists about the adverse effects of these herbal remedies. We report two patients who presented to us with vague complaints following the ingestion of kabasura kudineer and we diagnosed them with acute tubulointerstitial nephritis (ATIN). The temporal relationship of ingestion of these remedies to the development of ATIN calls for vigilance and caution with regular monitoring of renal functions especially in those with chronic kidney disease.
Effectiveness of facility‐based transition care on health‐related outcomes for older adults: A systematic review and meta‐analysis
Authors: Hang Jo‐Aine , Naseri Chiara , Francis‐Coad Jacqueline , Jacques Angela , Waldron Nicholas , Knuckey Robyn , Hill Anne‐Marie 
Published: July 2021

AbstractBackgroundAlthough Transition Care Programmes (TCP) are designed to assist older adults to regain functional ability after hospitalisation, it is unclear whether TCP improve older adults’ health‐related outcomes.ObjectivesThe objective of the review was to synthesise the best available evidence for the effectiveness of TCP on health‐related outcomes for older adults admitted to a transition care facility after hospitalisation.MethodsSearches were conducted using the databases PubMed, AMED (Ovid), Embase (Ovid), PscyINFO (Ovid) and CINAHL (Full text) and grey literature from January 2000 to May 2020 in English only. Studies that reported health‐related outcomes of older adults (aged 65 and above) who received TCP in a facility setting were deemed eligible for inclusion following critical appraisal by two reviewers. Data were pooled in meta‐analysis where possible, or reported narratively.ResultsA total of 21 studies from seven countries [(n = 5 RCT, n = 16 observational cohort studies) participants’ mean age 80.2 (±8.3)] were included. Pooled analysis (2069 participants, 7 studies) demonstrated that 80% of older adults undertaking TCP were discharged home [95% CI (0.78–0.82, p < 0.001), I2 = 21.99%, very low GRADE evidence]. Proportions of older adults discharged home varied widely between countries (33.3%–86.4%). There was a significant improvement in ability to perform activities of daily living (2001 participants, 7 studies) as measured by the Modified Barthel Index [17.65 points (95% CI 5.68–29.62, p = 0.004), I2 = 0.00%, very low GRADE evidence].ConclusionsThe proportion of older adults discharged home from TCP compared to other discharge destinations differs between countries. This could be due to the intensity of the rehabilitation delivered and the maximum length of stay allowed prior to discharge.Implications for PracticeFuture studies that comprehensively evaluate the efficacy of TCP on health‐related outcomes including quality of life are required. Further investigation is required to identify which aspects of TCP affect successful discharge home.
Immunogenicity of varicella zoster vaccine in pediatric liver transplantation
Authors: Atjayutpokin Thanwarat , Treepongkaruna Suporn , Apiwattanakul Nopporn , Techasaensiri Chonnamet , Lertudomphonwanit Chatmanee , Getsuwan Songpon , Boonsathorn Sophida 
Published: July 2021

AbstractBackgroundPediatric liver transplant (LT) candidates often miss complete varicella‐zoster virus (VZV) vaccination before LT. We aimed to evaluate the immunogenicity of two doses of VZV vaccines in pediatric LT candidates younger than 2 years and persistence of its immunogenicity after LT.MethodsPatients aged 9–24 months were enrolled before LT. The first dose of VZV vaccine was given at 9 months, and the second dose was given at between 1 to 3 months later, and at least 4 weeks before LT. Varicella‐zoster IgG (VZG) was used to detect immunoglobulin G antibodies to VZV and was reported as a test value (TV). A test value ≥ 0.9 was considered as seropositive. TV was measured at enrollment, 1 month after the first and the second dose of VZV vaccine, before LT, and 3 and 6 months after LT.ResultsFourteen children were enrolled in this prospective cohort study. The median age at the first and the second dose of VZV vaccine was 11.5 months (IQR 9–12) and 13 months (IQR 12–33), respectively. The seroconversion rate was 66.7% (8/12) and 70% (7/10) after the first and second VZV vaccine doses, respectively. Seven of nine patients who underwent LT had two doses of VZV vaccine. Six patients were seropositive before LT, which persisted at 3 to 6 months after LT. Of two patients who received only one dose, TV was not detected after LT.ConclusionsThe two doses of VZV vaccine appeared to be more immunogenic than one dose in pediatric LT candidates aged less than 2 years.
Low UVB Fluences Augment Microvesicle Particle Generation in Keratinocytes
Authors: Thapa Pariksha , Bhadri Shweta , Borchers Christina , Liu Langni , Chen Yanfang , Rapp Christine M. , Travers Jeffrey B. 
Published: July 2021

AbstractMicrovesicle particles (MVP) are bioactive subcellular particles which have been recently implicated in the keratinocyte response to many environmental stressors including ultraviolet B radiation (UVB). Previous studies have demonstrated that UVB generates high levels of MVP in a process involving the platelet‐activating factor receptor (PAFR) and the enzyme acid sphingomyelinase (aSMase). Yet the fluences of UVB needed to generate MVP are usually above those commonly encountered. Using models including human epithelial cell lines in vitro, human skin explants ex vivo and murine studies in vivo, the present studies indicate that pretreatment of epithelial cells/skin with PAFR agonist/phorbol ester can synergize with low fluences of UVB to generate high levels of MVP. These studies indicate the possibility that MVP could play a role in combinatorial pathologic processes involving UVB.
Significance of stratifin in early progression of lung adenocarcinoma and its potential therapeutic relevance
Authors: Shiba‐Ishii Aya 
Published: July 2021

AbstractLung cancer is the most common cause of global cancer‐related mortality, and the main histological type is adenocarcinoma, accounting for 50% of non‐small cell lung cancer. In 2015, the World Health Organization (WHO) histological classification defined the concepts of “adenocarcinoma in situ” (AIS) and “minimally invasive adenocarcinoma” (MIA), which are considered to be adenocarcinomas at a very early stage. Although AIS and MIA have a very favorable outcome, once they progress to early but invasive adenocarcinoma (eIA), they can sometimes have a fatal outcome. We previously compared the expression profiles of eIA and AIS, and identified stratifin (SFN; 14‐3‐3 sigma) as a protein showing significantly higher expression in eIA than in AIS. Expression of SFN is controlled epigenetically by DNA demethylation, and its overexpression is significantly correlated with poorer outcome. In vitro and in vivo analyses have shown that SFN facilitates early progression of adenocarcinoma by enhancing cell proliferation. This review summarizes genetic and epigenetic abnormalities that can occur in early‐stage lung adenocarcinoma and introduces recent findings regarding the biological significance of SFN overexpression during the course of lung adenocarcinoma progression. Therapeutic strategies for targeting SFN are also discussed.
Ultrasonographic findings of the corpus luteum and the gravid uterus during heat stress in dairy cattle
Authors: Nanas Ioannis , Barbagianni Mariana , Dadouli Katerina , Dovolou Eleni , Amiridis Georgios S 
Published: July 2021

AbstractThe objectives of this study were to assess alterations in, echogenic appearance, size and blood flow in the corpus luteum, the placentomes and the blood flow in umbilical and uterine arteries that heat stress can cause in cooled pregnant dairy cows. Pregnant cows were allocated in two groups and the gravid uteri, along with the ipsilateral corpora lutea were examined during the winter (group W, n = 9) or the summer (group S, n = 10). The grey‐scale ultrasound and colour flow imaging of the corpus luteum and placentome were performed. In addition, the umbilical and uterine artery diameters and haemodynamic parameters in the vessels were calculated. At the time of ultrasonographic examination, cortisol concentrations were higher, and progesterone levels tended to be lower in group S compared to group W. The grey‐scale ultrasound evaluation of corpora lutea and placentomes was lower in group S compared to group W. The diameter of umbilical artery and the blood volume in the vessel were less in group S than in group W. We infer that heat stress affects foetal blood supply and possibly the structure of placentomes and corpora lutea, but it differently affects the blood flow characteristics in the umbilical and uterine arteries.
Material characterization of curved shells under finite deformation using the virtual fields method
Authors: Livens Pieter , Avril Stéphane , Dirckx Joris J. J. 
Published: July 2021

AbstractAlthough full‐field measurement techniques have been well established, material characterization from these data remains challenging. Often, no closed‐form solution exists between measured quantities and sought material parameters. In this paper, a novel approach to determine the stiffness of thin curved membranes is proposed, based on the virtual fields method (VFM). Utilizing Kirchhoff‐Love shell theory, we show that the displacements can be decomposed into an in‐plane displacement and a rotation of the mid‐surface of the shell. Consequently, the strain tensor at the outer surface of the shell can then be decomposed into a membrane and a bending part. This allows for the VFM to be applied based only on data of the outer surface and on surfaces of arbitrary curvature. The method is first applied to simulated data. It is shown that the elastic modulus can be identified with less than 5% error if the thickness and Poisson ratio are known accurately. A 5% uncertainty in either the Poisson ratio or the thickness changes the identified value by 5%. Then, the method is applied on experimental data acquired on rubber samples having a dome‐like shape. Tensile tests are performed on the same samples, which permits to assess the linearized Young's modulus of this material for moderate strains (0–2.1%). Using regression analysis, a Young's modulus of 1.21 ± 0.08 MPa is found. Next, we performed pressurization tests on eight dome‐like shapes with pressures up to 4 kPa. The average Young's modulus obtained with the novel virtual fields method is 1.20 ± 0.13 MPa. The results are in good agreement with the ones from the tensile test. Future applications could benefit from this method to analyse more complex shapes, for example those found in biological structures like arteries or eardrums.
Characterization of the novel HLA‐DPA1*01:61 allele by sequencing‐based typing
Authors: Cargou Marine , Andreani Marco , Giustiniani Paola , Ralazamahaleo Mamy , Visentin Jonathan 
Published: July 2021

ABSTRACT
HLA‐DPA1*01:61 differs from HLA‐DPA1*01:03:01:22 by one nucleotide substitution in codon 96 in exon 3.
Maintaining mask momentum in transplant recipients
Authors: Puius Yoram A. , Bartash Rachel M. , Zingman Barry S. 
Published: July 2021

AbstractThe widespread use of facemasks has been a crucial element in the control of the SARS‐CoV‐2 pandemic. With mounting evidence for mask efficacy against respiratory infectious diseases and greater acceptability of this intervention, it is proposed that masking should continue after the pandemic has abated to protect some of our most vulnerable patients, recipients of stem cell and solid organ transplants. This may involve not only masking these high‐risk patients, but possibly their close contacts and the healthcare workers involved in their care. We review the evidence for mask efficacy in prevention of respiratory viruses other than SARS‐CoV‐2 and address the burden of disease in transplant recipients. Although we acknowledge that there are limited data on masking to prevent infection in transplant recipients, we propose a framework for the study and implementation of routine masking as a part of infection prevention interventions after transplantation.
International survey of human herpes virus 8 screening and management in solid organ transplantation
Authors: Mularoni Alessandra , Mikulska Malgorzata , Giannella Maddalena , Adamoli Lucia , Slavin Monica , Van Delden Christian , Garcia Jose Maria Aguado , Cervera Carlos , Grossi Paolo Antonio 
Published: July 2021

AbstractBackgroundHHV‐8/Kaposi Sarcoma herpesvirus has been associated with a broad spectrum of diseases in solid organ transplant (SOT) recipients. Primary donor‐derived infection can be associated with severe and rapidly fatal non‐neoplastic disease, and diagnosis is made with high HHV‐8 DNAemia.MethodsWe carried out an international survey to investigate the current approach to HHV‐8 screening, and management in SOT since a protocol has not been established by international guidelines.ResultsA total of 51 transplant centers from 15 countries filled out the survey. HHV‐8‐associated diseases in SOT have been diagnosed during the previous 5 years in 67% of centers. Pretransplant serological screening is performed in 17 centers (33%), and posttransplant HHV‐8 nucleic acid testing (NAT) monitoring is performed in 21 centers (41%). Performing HHV‐8 NAT monitoring and serological screening were found associated with having diagnosed in the previous 5 years a non‐malignant HHV‐8‐associated disease.ConclusionsSerological pretransplant screening of donors and recipients and post‐transplant HHV‐8 NAT monitoring recommendations should be standardized. Even though serological assays are not optimal, they could contribute to increasing knowledge on epidemiology and management of HHV‐8‐associated diseases after SOT.