bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring coverage of maternal and child health services using routine health facility data: a Sierra Leone case study
Authors: Maïga Abdoulaye , Amouzou Agbessi , Bagayoko Moussa , Faye Cheikh M. , Jiwani Safia S. , Kamara Dauda , Koroma Ibrahim B. , Sankoh Osman 
Published: September 2021

Abstract
Background
There are limited existing approaches to generate estimates from Routine Health Information Systems (RHIS) data, despite the growing interest to these data. We calculated and assessed the consistency of maternal and child health service coverage estimates from RHIS data, using census-based and health service-based denominators in Sierra Leone.

Methods
We used Sierra Leone 2016 RHIS data to calculate coverage of first antenatal care contact (ANC1), institutional delivery and diphtheria-pertussis-tetanus 3 (DPT3) immunization service provision. For each indicator, national and district level coverages were calculated using denominators derived from two census-based and three health service-based methods. We compared the coverage estimates from RHIS data to estimates from MICS 2017. We considered the agreement adequate when estimates from RHIS fell within the 95% confidence interval of the survey estimate.

Results
We found an overall poor consistency of the coverage estimates calculated from the census-based methods. ANC1 and institutional delivery coverage estimates from these methods were greater than 100% in about half of the fourteen districts, and only 3 of the 14 districts had estimates consistent with the survey data. Health service-based methods generated better estimates. For institutional delivery coverage, five districts met the agreement criteria using BCG service-based method. We found better agreement for DPT3 coverage estimates using DPT1 service-based method as national coverage was close to survey data, and estimates were consistent for 8 out of 14 districts. DPT3 estimates were consistent in almost half of the districts (6/14) using ANC1 service-based method.

Conclusion
The study highlighted the challenge in determining an appropriate denominator for RHIS-based coverage estimates. Systematic and transparent data quality check and correction, as well as rigorous approaches to determining denominators are key considerations to generate accurate coverage statistics using RHIS data.
RETRACTED ARTICLE: Long non-coding RNA SLC2A1-AS1 induced by GLI3 promotes aerobic glycolysis and progression in esophageal squamous cell carcinoma by sponging miR-378a-3p to enhance Glut1 expression
Authors: Liu Hongtao , Zhang Qing , Song Yinsen , Hao Yibin , Cui Yunxia , Zhang Xin , Zhang Xueying , Qin Yue , Zhu Guangzhao , Wang Feng , Dang Jinghan , Ma Shanshan , Zhang Yanting , Guo Wenna , Li Shenglei , Guan Fangxia , Fan Tianli 
Published: September 2021

Abstract
Background
Emerging evidence demonstrates that lncRNAs play pivotal roles in tumor energy metabolism; however, the detailed mechanisms of lncRNAs in the regulation of tumor glycolysis remain largely unknown.

Methods
The expression of SLC2A1-AS1 was investigated by TCGA, GEO dataset and qRT-PCR. The binding of GLI3 to SLC2A1-AS1 promoter was detected by Luciferase Reporter Assay System and Ago2-RIP assay. FISH was performed to determine the localization of SLC2A1-AS1 in ESCC cells. Double Luciferase Report assay was used to investigate the interaction of miR-378a-3p with SLC2A1-AS1 and Glut1. Gain-of-function and Loss-of-function assay were performed to dissect the function of SLC2A1-AS1/miR-378a-3p/Glut1 axis in ESCC progression in vitro and in vivo.

Results
We identified a novel lncRNA SLC2A1-AS1 in ESCC. SLC2A1-AS1 was frequently overexpressed in ESCC tissues and cells, and its overexpression was associated with TNM stage, lymph node metastasis and poor prognosis of ESCC patients. Importantly, GLI3 and SLC2A1-AS1 formed a regulatory feedback loop in ESCC cells. SLC2A1-AS1 promoted cell growth in vitro and in vivo, migration and invasion, and suppressed apoptosis, leading to EMT progression and increased glycolysis in ESCC cells. SLC2A1-AS1 functioned as ceRNA for sponging miR-378a-3p, resulting in Glut1 overexpression in ESCC cells. MiR-378a-3p inhibited cell proliferation and invasion as well as induced apoptosis, resulting in reduced glycolysis, which was partly reversed by SLC2A1-AS1 or Glut1 overexpression in ESCC cells.

Conclusion
SLC2A1-AS1 plays important roles in ESCC development and progression by regulating glycolysis, and SLC2A1-AS1/miR-378a-3p/Glut1 regulatory axis may be a novel therapeutic target in terms of metabolic remodeling of ESCC patients.
Efficacy of fipronil/(S)-methoprene/eprinomectin/praziquantel (Broadline®) against Thelazia callipaeda in naturally infected cats
Authors: Zanet Stefania , Morelli Simone , Di Cesare Angela , Bò Stefano , Traversa Donato , Lebon Wilfried , Beugnet Frederic , Simonato Giulia , Ferroglio Ezio 
Published: September 2021

Abstract
Background
The present clinical field trial was conducted to assess the efficacy of a broad-spectrum parasiticide spot-on formulation containing eprinomectin (Broadline®) against Thelazia callipaeda eyeworm in naturally infected cats.

Methods
Fifteen privately owned cats harboring at least one live adult T. callipaeda were included in the study. Cats were randomly allocated to an untreated control group of seven cats or to a Broadline®-treated group of eight cats. Cats were treated on Day 0; ocular examinations were performed at inclusion and on Days 7 and 14; eyeworms were recovered and counted on Day 14. The primary efficacy assessment was based on group comparison of number of T. callipaeda on Day 14.

Results
Seven days after treatment, six of eight treated cats were negative for eyeworm infection per visual examination, and on Day 14 no eyeworms were found in the treated cats while the seven untreated cats were still infected (geometric mean: 1.97). All cats had inflammatory ocular signs at inclusion; on Day 14, five of eight treated cats had recovered while all untreated control cats were still symptomatic. All collected parasites were confirmed to be T. callipaeda by morphology and molecular characterization.

Conclusions
A single treatment with Broadline® provided 100% efficacy against feline thelaziosis and improved related ocular inflammation signs.

Graphical abstract
Disruption of the white matter structural network and its correlation with baseline progression rate in patients with sporadic amyotrophic lateral sclerosis
Authors: Li Wenbin , Wei Qianqian , Hou Yanbing , Lei Du , Ai Yuan , Qin Kun , Yang Jing , Kemp Graham J. , Shang Huifang , Gong Qiyong 
Published: September 2021

AbstractObjectiveThere is increasing evidence that amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease impacting large-scale brain networks. However, it is still unclear which structural networks are associated with the disease and whether the network connectomics are associated with disease progression. This study was aimed to characterize the network abnormalities in ALS and to identify the network-based biomarkers that predict the ALS baseline progression rate.MethodsMagnetic resonance imaging was performed on 73 patients with sporadic ALS and 100 healthy participants to acquire diffusion-weighted magnetic resonance images and construct white matter (WM) networks using tractography methods. The global and regional network properties were compared between ALS and healthy subjects. The single-subject WM network matrices of patients were used to predict the ALS baseline progression rate using machine learning algorithms.ResultsCompared with the healthy participants, the patients with ALS showed significantly decreased clustering coefficientCp(P = 0.0034,t = 2.98), normalized clustering coefficientγ(P = 0.039,t = 2.08), and small‐worldnessσ(P = 0.038,t = 2.10) at the global network level. The patients also showed decreased regional centralities in motor and non-motor systems including the frontal, temporal and subcortical regions. Using the single-subject structural connection matrix, our classification model could distinguish patients with fast versus slow progression rate with an average accuracy of 85%.ConclusionDisruption of the WM structural networks in ALS is indicated by weaker small-worldness and disturbances in regions outside of the motor systems, extending the classical pathophysiological understanding of ALS as a motor disorder. The individual WM structural network matrices of ALS patients are potential neuroimaging biomarkers for the baseline disease progression in clinical practice.
In the post-COVID-19 era, is the illegal wildlife trade the most serious form of trafficking?
Authors: Doody J. Sean , Reid Joan A. , Bilali Klejdis , Diaz Jennifer , Mattheus Nichole 
Published: September 2021

AbstractDespite the immense impact of wildlife trafficking, comparisons of the profits, costs, and seriousness of crime consistently rank wildlife trafficking lower relative to human trafficking, drug trafficking and weapons trafficking. Using the published literature and current events, we make the case, when properly viewed within the context of COVID-19 and other zoonotic diseases transmitted from wildlife, that wildlife trafficking is the most costly and perhaps the most serious form of trafficking. Our synthesis should raise awareness of the seriousness of wildlife trafficking for humans, thereby inducing strategic policy decisions that boost criminal justice initiatives and resources to combat wildlife trafficking.
Exploring the relationships between various dimensions of receptive vocabulary knowledge and L2 listening and reading comprehension
Authors: Ha Hung Tan 
Published: September 2021

AbstractThe article presents an empirical study that investigates the single- and cross-modality relationships between different dimensions of receptive vocabulary knowledge and language skills, as well as the importance of academic vocabulary knowledge in academic listening and reading comprehension. An Updated Vocabulary Levels Test (UVLT), a Vietnamese version of the Listening Vocabulary Levels Test (LVLT), an International English Language Testing System (IELTS) listening test and an academic IELTS reading test were administered to 234 tertiary level Vietnamese learners of English as a foreign language (EFL). Research findings showed that (1) orthographic and aural vocabulary knowledge were strongly correlated (r = .88) and of equal significance to L2 listening and reading comprehension, (2) receptive vocabulary knowledge was a very powerful and reliable predictor of learners’ receptive language proficiency, (3) knowledge of academic vocabulary strongly correlated with academic listening (r = .65) and reading (r = .60) comprehension and the mastery of the Academic Word List (AWL) could suggest a band score 6.0 in both the IELTS listening and academic reading tests.
What factors impact pedestrian and cyclist fatalities? A state level analysis
Authors: Hafeez Zoabe , Mehta Malvi 
Published: September 2021

Abstract
Background
Pedestrian and bicyclist injuries and fatalities have increased since 2010 after a long downward trend. Trucks and SUVs, collectively called light trucks, have also increased in sales and size, which may affect pedestrians and bicyclists. Additionally, pedestrian and cyclist commuters vary by state and it has been speculated that an increase in such commuters may affect fatalities. Studying vulnerable road users can bestow clues on best practices for infrastructure and public health.

Methods
State level pedestrian and cyclist fatality data was obtained from the National Highway Transportation Safety Administration for 2018. Light truck registration by state was obtained from the Office of Highway Policy Information for 2018. Commuters who walk or bike to work were obtained from the American Community Survey from 2009 to 2011, from the latest Centers for Disease Control report. We performed multiple linear regression, accounting for total motor vehicle lane miles per 100 people, also obtained from the Office of Highway Policy Information for 2018. Multiple regression analysis was performed to assess predictors for pedestrian and cyclist fatalities with the predictors variables of light truck registration, lane miles per 100 people, and proportion of commuters who are vulnerable road users. Secondary analysis included simple linear regression of the predictor variables against each other.

Results
The multiple regression model, including proportion of light truck registration, lane miles per 100 people, and proportion of commuters who are vulnerable road users, accounted for 18% of the variability in the outcome variable (p = 0.03). An increased number of vulnerable road users were negatively associated with pedestrian and bicyclist fatality. Additionally, there appeared to be an association between motor vehicle lane miles per 100 people and proportion of light truck registrations that was also significant (p < 0.01).

Conclusion
The variables affecting vulnerable road user deaths are important to understand given their increased risk exposure on the road. This state level study identifies a potential protective variable with increased vulnerable road users being associated with a decrease in pedestrian and bicyclist death rates. Additionally, light truck proportions do not appear to have a significant effect on death rates.
NanoSIMS and EPMA dating of lunar zirconolite
Authors: Wang Nian , Mao Qian , Zhang Ting , Hao Jialong , Lin Yangting 
Published: September 2021

Abstract
Zirconolite is a common Zr-rich accessary mineral in mafic rocks. It is also an ideal U–Pb/Pb–Pb chronometer because it commonly contains high U content (mostly 0.1–10 wt%) and negligible initial Pb. However, zirconolite is usually very small (e.g., ~ 1 μm in width) in lunar rocks, requiring a high spatial resolution analysis. We analyzed a single, large (25 μm × 20 μm) grain of zirconolite in lunar meteorite NWA 4485 using Pb–Pb dating by NanoSIMS and U–Th–Pb dating by EPMA. The resultant U–Th–Pb age is 4540 ± 340 Ma (2σ) with a spatial resolution of 1.3 μm. The Pb–Pb age by NanoSIMS is 4348.5 ± 4.8 Ma (2σ) with a spatial resolution of ~ 2 μm, consistent with the age of 4352 ± 10 Ma and 4344 ± 14 Ma reported in the same meteorite and its paired meteorite NWA 4472. Although U–Th–Pb age is somewhat older, it still includes the NanoSIMS results within the analytical uncertainty. This work demonstrates the potential application of the combined EPMA dating and REE analysis of lunar zirconolite, with the benefits of high spatial resolution, non-destructive, and readily accessibility of the instrument. The precision of the EPMA dating (7.6%, 2σ) can be improved by increasing the counting time for Pb, U and Th. We expect to apply this EPMA technique for a quick and non-destructive age survey and geochemical study of zirconolite grains from the lunar mare basalts newly returned by Chang’E-5 mission which landed on a very young (1.2–2.0 Ga by crater-counting chronology) basalt unit in Procellarum KREEP Terrain.
A cross-sectional study of olfactory and taste disorders among COVID-19 patients in China
Authors: Li Jian-Hui , Sun Yi , Li Mei-Rong , Yuan Hu , Yang Chang-Liang , Huang Cheng-Cheng , Zhou Feng-Jie , Chen Rui-Yao , Zhang Lei-Bo , Yu Ning , Liu Qiong , He Jing-Jing , Zhou Xue-Jun , Fu Xiao-Bing , Yang Shi-Ming 
Published: September 2021

AbstractTo determine the prevalence and clinical features of olfactory and taste disorders among coronavirus disease 2019 (COVID-19) patients in China. A cross-sectional study was performed in Wuhan from April 3, 2020 to April 15, 2020. A total of 187 patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) completed face-to-face interviews or telephone follow-ups. We found that the prevalence of olfactory and taste disorders was significantly lower in the Chinese cohort than in foreign COVID-19 cohorts. Females were more prone to olfactory and taste disorders. In some patients, olfactory and taste disorders precede other symptoms and can be used as early screening and warning signs.
Data and optimization model of an industrial heat transfer station to increase energy flexibility
Authors: Kohne Thomas , Theisinger Lukas , Scherff Jan , Weigold Matthias 
Published: September 2021

AbstractNations and companies are forced to reduce CO2emissions and decelerate global warming. In this development, the transition of the heating sector is still in its infancy despite the relatively large share of thermal energy in the total energy consumption. Industrial companies can contribute significantly to reduce CO2emissions by using waste heat through connecting their industrial energy supply system (IESS) to a district heating system (DHS). This paper focuses on emission reduction potential of an (industrial) heat transfer station (HTS) regarding energy flexibility and sector coupling required for the successful integration of industrial waste heat. To optimize the operating behaviour of the HTS, a data and optimization model is integrated into a digital twin (DT) based on reference architecture model for industry 4.0 (RAMI4.0). Within the DT, the information, functional and business layer are modeled. The effects of operating the HTS supported by central modules of the DT are evaluated on one year’s data of an IESS of a real industrial site. The results show a potential operating cost reduction by 6 % for the IESS and increases in profits of 1.3 % for the DHS. Scope 2 emissions can be reduced by 25 % for the IESS and 180 % for the DHS respectively, strongly depending on emission factors and allocation methods.
Destructive reconstruction in China: interpreting authenticity in the Shuidong Reconstruction Project, Huizhou, Guangdong Province
Authors: Yang Zilin 
Published: September 2021

AbstractIn the name of conservation, many local governments in China have demolished and reconstructed their historic districts using pseudo-antique architecture as part of their commercial developments. While the destructive reconstruction practice involves issues such as who plays the decisive role in defining authenticity in the targeted district considering the creativity and imagination entailed in reconstruction, few studies analyse the factors leading to changes in the interpretation of authenticity throughout the destructive reconstruction process. Through a discourse analysis on project portfolios and semi-structured interviews with government officials, project planners and Shuidong residents, this study investigates the interpretation and implementation of the national-level authenticity principles in the Shuidong Reconstruction Project in Huizhou, Guangdong Province. Narratives of authenticity in local heritage practices are constantly changing because of the shifting local politics and regulatory powers involved. The effectiveness of national-level authenticity principles at the local level relies largely on the establishment of sub-national heritage regulations and the authorisation of heritage, which draws inspections from upper-level administrations. This study reveals certain socio-political factors that affect the relationship between reconstruction practices and the interpretation of authenticity. The political and profit-oriented tendency of local heritage conservation practices in China demonstrates the mismatch between conservation ideologies and bureaucratic realities.
Ultra spin liquid in Lu3Cu2Sb3O14
Authors: Shaginyan V. R. , Msezane A. Z. , Artamonov S. A. , Japaridze G. S. , Leevik Y. S. 
Published: September 2021

Abstract
We analyze recent measurements of C/T, specific heat C divided by temperature T, of a recently observed ultra spin liquid. The measurements are carried out in magnetic fields on the triangular lattice compound

. We show that the obtained heat capacity

formed by the ultra spin liquid as a function of temperature T vs. magnetic field B behaves very similar to the electronic specific heat

of the HF metal

and the quantum magnet

. We demonstrate that the effective mass of spinon

exhibits the universal scaling coinciding with scaling observed in heavy-fermion (HF) metals and in

. Based on these observations we conclude that a strongly correlated spin liquid determines the thermodynamic properties of the ultra spin liquid of

.
Thyroid Function and Risk of Anemia: A Multivariable-Adjusted and Mendelian Randomization Analysis in the UK Biobank
Authors: van Vliet Nicolien A , Kamphuis Annelies E P , den Elzen Wendy P J , Blauw Gerard J , Gussekloo Jacobijn , Noordam Raymond , van Heemst Diana 
Published: September 2021

Abstract

Context
Thyroid dysfunction is associated with higher anemia prevalence, although causality remains unclear.

Objective
This study aimed to investigate the association between thyroid function and anemia.

Methods
This cross-sectional and Mendelian randomization study included 445 482 European participants from the UK Biobank (mean age 56.77 years (SD 8.0); and 54.2% women). Self-reported clinical diagnosis of hypothyroidism was stated by 21 860 (4.9%); self-reported clinical diagnosis of hyperthyroidism by 3431 (0.8%). Anemia, defined as hemoglobin level of &lt; 13 g/dL in men and &lt; 12 g/dL in women, was present in 18 717 (4.2%) participants.

Results
In cross-sectional logistic regression analyses, self-reported clinical diagnoses of hypo- and hyperthyroidism were associated with higher odds of anemia (OR 1.12; 95% CI, 1.05-1.19 and OR 1.09; 95% CI, 0.91-1.30), although with wide confidence intervals for hyperthyroidism. We did not observe an association of higher or lower genetically influenced thyrotropin (TSH) with anemia (vs middle tertile: OR for lowest tertile 0.98 [95% CI, 0.95-1.02]; highest tertile 1.02 [95% CI, 0.98-1.06]), nor of genetically influenced free thyroxine (fT4) with anemia. Individuals with genetic variants in the DIO3OS gene implicated in intracellular regulation of thyroid hormones had a higher anemia risk (OR 1.05; 95% CI, 1.02-1.10); no association was observed with variants in DIO1 or DIO2 genes.

Conclusion
While self-reported clinical diagnosis of hypothyroidism was associated with higher anemia risk, we did not find evidence supporting a causal association with variation of thyroid function within the euthyroid range. However, intracellular regulation of thyroid hormones might play a role in developing anemia.