bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial‐mesenchymal plasticity of human peritoneal mesothelial cells
Authors: Gao Lingling , Nie Xin , Gou Rui , Hu Yuexin , Dong Hui , Li Xiao , Lin Bei 
Published: November 2021

AbstractOvarian cancer, one of the malignant gynaecological tumours with the highest mortality rate among female reproductive system, is prone to metastasis, recurrence and chemotherapy resistance, causing a poor prognosis. Exosomes can regulate the epithelial‐mesenchymal plasticity of tumour cells, remodel surrounding tumour microenvironment, and affect tumour cell proliferation, invasion and metastasis. However, the function and mechanism of exosomes in the intraperitoneal implantation of ovarian cancer remain unclear. In this study, exosomal annexin A2 (ANXA2) derived from ovarian cancer cells was co‐cultured with human peritoneal mesothelial (HMrSV5) cells; functional experiments were conducted to explore the effects of exosomal ANXA2 on the biological behaviour of HMrSV5 and the related mechanisms. This study showed that ANXA2 in ovarian cancer cells can be transferred to HMrSV5 cells through exosomes, exosomal ANXA2 can not only promote the migration, invasion and apoptosis of HMrSV5 cells, but also regulates morphological changes and fibrosis of HMrSV5 cells. Furthermore, ANXA2 promotes the mesothelial‐mesenchymal transition (MMT) and degradation of the extracellular matrix of HMrSV5 cells through PI3K/AKT/mTOR pathway, finally affects pre‐metastasis microenvironment of ovarian cancer, which provides a new theoretical basis for the mechanism of intraperitoneal implantation and metastasis of ovarian cancer.
Relationship between hemoglobin A1c level and flow‐mediated vasodilation in patients with type 2 diabetes mellitus receiving antidiabetic drugs
Authors: Yamaji Takayuki , Harada Takahiro , Hashimoto Yu , Nakano Yukiko , Kajikawa Masato , Yoshimura Kenichi , Aoki Gaku , Chayama Kazuaki , Goto Chikara , Mizobuchi Aya , Han Yiming , Yusoff Farina Mohamad , Kishimoto Shinji , Maruhashi Tatsuya , Nakashima Ayumu , Higashi Yukihito 
Published: November 2021

ABSTRACTAims/IntroductionDiabetes mellitus is associated with endothelial dysfunction. However, it is still controversial as to whether antidiabetic drug treatment affects endothelial function. The purpose of this study was to evaluate the relationships of the hemoglobin A1c (HbA1c) level with flow‐mediated vasodilation (FMD) and nitroglycerine‐induced vasodilation (NID) in patients with type 2 diabetes mellitus who are receiving antidiabetic drugs.Materials and MethodsThe FMD was measured in 866 patients with type 2 diabetes mellitus who were receiving antidiabetic drugs (625 men and 241 women; mean age: 62 ± 10 years). The patients were divided into four groups according to HbA1c levels: <6.5, 6.5–6.9, 7.0–7.9, and ≥8.0%.ResultsThere was an inverted U‐shaped pattern of association of the HbA1c level with the FMD at an HbA1c level of about 7% of the peak of FMD in patients with type 2 diabetes mellitus who were receiving antidiabetic drugs. The FMD was significantly smaller in the HbA1c <6.5% group than in the HbA1c 6.5–6.9% group and the HbA1c 7.0–7.9% group (P < 0.001 and P < 0.001, respectively). The FMD values were similar in the HbA1c <6.5% group and HbA1c ≥8.0% group (P = 0.10). There were no significant differences in NID among the four groups (P = 0.98).ConclusionsThese findings suggest that a low HbA1c <6.5% as well as a high HbA1c ≥8.0% is associated with endothelial dysfunction in patients with type 2 diabetes mellitus who are receiving antidiabetic drugs and that vascular smooth muscle function is similar in such patients regardless of the HbA1c level.
Engaging parents in preventive programs for adolescent mental health: A socio‐ecological framework
Authors: Finan Samantha Jane , Yap Marie B. H. 
Published: November 2021

AbstractPreventive parenting programs have been demonstrated to decrease the risk of adolescent mental health problems. Despite this, recruitment and engagement rates in these programs are low, which could lead to an underreporting of the effectiveness of these programs and parents not adequately developing the key skills required to prevent mental health problems in their adolescent. We propose a framework for understanding parental initial engagement using a socio‐ecological lens, by considering a variety of factors that apply across several levels: intrapersonal, interpersonal, organizational, community, and public policy. Implications of this conceptual framework and future directions for research and practice are then discussed.
Non‐Deal Roadshows, Informed Trading, and Analyst Conflicts of Interest
Authors: BRADLEY DANIEL , JAME RUSSELL , WILLIAMS JARED 
Published: November 2021

ABSTRACTNon‐deal roadshows (NDRs) are private meetings between management and institutional investors, typically organized by sell‐side analysts. We find that around NDRs, local institutional investors trade heavily and profitably, while retail trading is significantly less informed. Analysts who sponsor NDRs issue significantly more optimistic recommendations and target prices, together with more “beatable” earnings forecasts, consistent with analysts issuing strategically biased forecasts to win NDR business. Our results suggest that NDRs result in a substantial information advantage for institutional investors and create significant conflicts of interests for the analysts who organize them.
Multi‐disciplinary management of an unusual presentation of bilateral mandibular dentigerous cysts in a non‐syndromic child
Authors: Keogh Aoife , Besi Eleni , Ulhaq Aman 
Published: November 2021

AbstractAimBilateral dentigerous cysts of the mandible are extremely rare in non‐syndromic patients with <30 cases reported in the literature with only one involving successful orthodontic alignment of the affected teeth. This case aims to highlight a rare bilateral presentation of dentigerous cysts in a non‐syndromic child in addition to encouraging clinicians to consider multi‐disciplinary care for the management of cysts not only for successful resolution of the cystic spaces but also for subsequent successful orthodontic alignment of severely displaced teeth.Material and MethodsA 12‐year old boy was referred to the paediatric dental department at the Edinburgh Dental Institute regarding partially erupted mandibular first permanent molars with suppuration and periodontal pocketing of 12mm. Radiographic examination revealed bilateral unilocular radiolucencies of the mandible associated with the partially erupted first and unerupted second permanent molars. The treatment to date includes oral hygiene advice, bilateral incisional biopsies and marsupialisation of the lesions under general anaesthetic, expose and bond procedures of the impacted mandibular second permanent molars and maxillary and mandibular fixed appliances.ResultsBoth the first and second lower permanent molars have been successfully aligned within the arch. Histological analysis has confirmed the diagnosis of bilateral dentigerous cysts of the mandible although provisional diagnosis included bilateral keratocysts.This patient has had both clinical and radiographic follow‐up in the paediatric dental, oral surgery and orthodontic departments over a 4‐year period.ConclusionThis is a highly unusual presentation of bilateral mandibular dentigerous cysts in a non‐syndromic child. Successful multi‐disciplinary care between the paediatric, oral surgery and orthodontic departments yielded an extremely favourable outcome for this challenging case. Paediatric dentists should be aware of this unusual presentation, the subsequent appropriate referral pathway and the promising feasibility of successful orthodontic alignment of the affected teeth.
Dermatologic manifestations of pediatric cardiovascular diseases: Skin as a reflection of the heart
Authors: Jones Virginia A. , Patel Payal M. , Valikodath Tom , Ashack Kurt A. 
Published: November 2021

AbstractCutaneous disease can often be an initial clue of an underlying cardiovascular disease. Many congenital conditions (ie, Noonan syndrome with multiple lentigines, Carney complex, and Fabry disease) and acquired conditions may present initially with specific cutaneous features that should prompt clinicians to conduct a full cardiac workup. Given the extensive number of conditions with both cardiovascular and cutaneous findings, this review will focus on diseases with cardiocutaneous pathology with hopes of raising clinician awareness of these associations to decrease morbidity and mortality, as several of these diseases often result in fatal outcomes.
Simultaneous occurrence of idiopathic trachyonychia in dizygotic twins
Authors: Bibb Lorin A. , Chang Mary Wu 
Published: November 2021

AbstractTrachyonychia (or twenty‐nail dystrophy) is an uncommon chronic disorder manifesting as thin, flattened, brittle nails with excessive longitudinal ridging and loss of luster creating a “sandpaper‐like” texture that most commonly presents spontaneously in childhood as an isolated phenomenon; however, it has been historically associated with numerous dermatoses. Rarely, trachyonychia has been reported to occur in families, suggesting a potential hereditary predisposition. We report trachyonychia occurring simultaneously in dizygotic twins, further supporting a possible underlying genetic basis of this idiopathic nail disorder.
Impact of a clinical pathway on acute kidney injury in patients undergoing heart transplant
Authors: Algaze Claudia A. , Margetson Tristan D. , Sutherland Scott M. , Kwiatkowski David M. , Maeda Katsuhide , Navaratnam Manchula , Samreth Sarah P. , Price Elizabeth P. , Zook Nina B. , Yang Jeffrey K. , Hollander Seth A. 
Published: November 2021

AbstractBackgroundTo evaluate the impact of a clinical pathway on the incidence and severity of acute kidney injury in patients undergoing heart transplant.MethodsThis was a 2.5‐year retrospective evaluation using 3 years of historical controls within a cardiac intensive care unit in an academic children's hospital. Patients undergoing heart transplant between May 27, 2014, and April 5, 2017 (pre‐pathway) and May 1, 2017, and November 30, 2019 (pathway) were included. The clinical pathway focused on supporting renal perfusion through hemodynamic management, avoiding or delaying nephrotoxic medications, and providing pharmacoprophylaxis against AKI.ResultsThere were 57 consecutive patients included. There was an unadjusted 20% reduction in incidence of any acute kidney injury (p = .05) and a 17% reduction in Stage 2/3 acute kidney injury (p = .09). In multivariable adjusted analysis, avoidance of Stage 2/3 acute kidney injury was independently associated with the clinical pathway era (AOR −1.3 [95% CI −2.5 to −0.2]; p = .03), achieving a central venous pressure of or less than 12 mmHg (AOR −1.3 [95% CI −2.4 to −0.2]; p = .03) and mean arterial pressure above 60 mmHg (AOR −1.6 [95% CI −3.1 to −0.01]; p = .05) in the first 48 h post‐transplant, and older age at transplant (AOR ‐ 0.2 [95% CI −0.2 to −0.06]; p = .002).ConclusionsThis report describes a renal protection clinical pathway associated with a reduction in perioperative acute kidney injury in patients undergoing heart transplant and highlights the importance of normalizing perioperative central venous pressure and mean arterial blood pressure to support optimal renal perfusion.
AID is a poor prognostic marker of high‐grade B‐cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements
Authors: Miyaoka Masashi , Kikuti Yara Yukie , Carreras Joaquim , Itou Atsushi , Ikoma Haruka , Tomita Sakura , Shiraiwa Sawako , Ando Kiyoshi , Nakamura Naoya 
Published: November 2021

AbstractDiffuse large B‐cell lymphoma with MYC rearrangement is defined as double/triple‐hit lymphoma (DHL/THL) or single‐hit lymphoma (SHL) by the inclusion of the BCL2 and BCL6 rearrangements status. DHL/THL is called as “high‐grade B‐cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements” in the World Health Organization 2017 Classification of Tumors of Hematopoietic and Lymphoid Tissues. To find a prognostic biomarker of DHL/THL, we firstly examined 19 cases (molecular analysis series;10 cases of DHL/THL and 9 cases of SHL) with gene expression profile analysis. The gene expression profile analysis showed that the high expression of AICDA was associated with an adverse prognosis in DHL/THL, but not in SHL. Then, we evaluated immunohistochemical expression of AID, the protein product of AICDA, in 50 cases (molecular analysis series of 19 cases and additional immunohistochemistry series of 31 cases; 12 cases of DHL/THL and 19 cases of SHL) and confirmed that its expression was also associated with an adverse prognosis in DHL/THL. Therefore, AICDA and AID can be a predictor of an adverse clinical outcome in DHL/THL and immunohistochemistry of AID is useful to find DHL/THL‐adverse prognosis group.
High‐flow arteriovenous fistula and hemodynamic consequences at 1 year after kidney transplantation
Authors: Keller Nicolas , Monnier Alexandra , Caillard Sophie , Cognard Noëlle , Geny Bernard , Moulin Bruno , Talha Samy 
Published: November 2021

AbstractIntroductionThere are only scarce data regarding the cardiovascular impact of arteriovenous fistula after kidney transplantation depending on fistula flow.MethodsWe performed a single‐center, prospective, cohort study including 49 patients with a functional fistula at 1 year from kidney transplantation. Patients were convened for a clinical work‐up, a biological analysis, a fistula's Doppler ultrasonography and an echocardiography. Main judgment criterion was comparison of echocardiography parameters between patients with relative (fistula flow >1 L/min and a fistula flow/cardiac output ratio >20%), absolute high‐flow fistula (fistula flow >2 L/min) and normal‐flow fistula.ResultsHigh‐flow fistula frequency was 69%. Significantly higher left ventricular end‐diastolic and systolic diameters were observed in this group compared with the normal‐flow fistula group (53 ± 6 vs. 48 ± 7 mm; p = 0.04 and 33 ± 6 vs. 28 ± 8 mm; p = 0.02) and between the absolute and relative high‐flow fistula subgroups (56 ± 6 vs. 51 ± 6 mm; p = 0.009 and 35 ± 6 vs. 31 ± 5 mm; p = 0.01). The study showed no other significant differences.ConclusionsThis study showed a significantly higher but not pathological left ventricular end‐diastolic and systolic diameters values in patients with high‐flow fistula compared with patients with normal‐flow fistula and between patients with respectively absolute and relative high‐flow fistula.
Semantic Roles or Syntactic Functions: The Effects of Annotation Scheme on the Results of Dependency Measures
Authors: Yan Jianwei , Liu Haitao 
Published: November 2021

AbstractThe annotation scheme of dependency treebanks might have an impact on the results of linguistic analysis, thus leading to different interpretations of linguistic phenomena. This study compares the results of two widely used dependency measures, i.e., dependency direction and dependency distance, based on 18 parallel Universal Dependencies (UD) annotated treebanks and 18 corresponding Surface‐Syntactic Universal Dependencies (SUD) annotated treebanks. The results show that (1) Based on the semantic UD and syntactic SUD, dependency relations between function words and content words share the opposite dependency directions but similar dependency distances; (2) Annotation scheme has a significant impact on dependency direction, though the effect size is small. We find that the proportions of head‐final dependencies based on the syntactic SUD can better group language families than those based on semantic UD; (3) Annotation scheme also affects dependency distance significantly, though its effect size is small. Mean dependency distances (MDDs) based on UD are always higher than those based on SUD. However, the MDDs based on both annotation schemes are within a certain threshold, which shows that the linguistic universal of dependency distance minimization is independent of annotation schemes.
Glucuronidation of type II arabinogalactan polysaccharides function in sexual reproduction of Arabidopsis
Authors: Ajayi Oyeyemi O. , Held Michael A. , Showalter Allan M. 
Published: November 2021

SUMMARYArabinogalactan proteins (AGPs) are complex, hyperglycosylated plant cell wall proteins with little known about the biological roles of their glycan moieties in sexual reproduction. Here, we report that GLCAT14A, GLCAT14B, and GLCAT14C, three enzymes responsible for the addition of glucuronic acid residues to AGPs, function in pollen development, polytubey block, and normal embryo development in Arabidopsis. Using biochemical and immunolabeling techniques, we demonstrated that the loss of function of the GLCAT14A, GLCAT14B, and GLCAT14C genes resulted in disorganization of the reticulate structure of the exine wall, abnormal development of the intine layer, and collapse of pollen grains in glcat14a/b and glcat14a/b/c mutants. Synchronous development between locules within the same anther was also lost in some glcat14a/b/c stamens. In addition, we observed excessive attraction of pollen tubes targeting glcat14a/b/c ovules, indicating that the polytubey block mechanism was compromised. Monosaccharide composition analysis revealed significant reductions in all sugars in glcat14a/b and glcat14a/b/c mutants except for arabinose and galactose, while immunolabeling showed decreased amounts of AGP sugar epitopes recognized by glcat14a/b and glcat14a/b/c mutants compared with the wild type. This work demonstrates the important roles that AG glucuronidation plays in Arabidopsis sexual reproduction and reproductive development.
A comparison between liquid group A plasma and thawed group A plasma for massive transfusion activation in trauma patients
Authors: Fadeyi Emmanuel A. , Saha Amit K. , Soltani Sohaila , Naal Tawfeq , Palmer Robert , Bakht Azad , Warren Christina S. , Simmons Julie H. , Pomper Gregory J. 
Published: November 2021

AbstractBackground and ObjectivesThe use of group A thawed 24‐h plasma when resuscitating haemorrhagic shock patients has become more common; however, limited data exist on the clinical use of liquid plasma (LP). Our aim is to determine whether LP is of clinical benefit to patients requiring massive transfusion.Materials and MethodsThe objective of this retrospective study was to detect any difference in 24‐h survival between patients receiving liquid or thawed plasma (TP) during their massive transfusion activation. Other objectives were to report any difference in hospital length of stay (LOS), intensive care unit (ICU) LOS and in‐hospital survival. Data collected included gender, age, mechanism of injury, Injury Severity Score, Revised Trauma Score and Trauma Injury Severity Score.ResultsA total of 178 patients received 1283 units of LP, median 4 and range (1–56), whereas 270 patients received 2031 units of TP, median 5 and range (1–87). The two study groups were comparable in terms of gender, age, mechanism of injury, whole blood, red blood cells, platelets and cryoprecipitate transfused. The use of LP during the massive transfusion activation in traumatically injured patients was not associated with increased 24‐h survival compared to when using TP, p = 0.553.ConclusionOur study did not show a difference in 24‐h or 30‐day survival between the use of LP compared to TP in trauma patients. LP should be considered an alternative to TP in trauma patients requiring immediate plasma resuscitation.
English and regional identity in ASEAN
Authors: Lee Huan Yik , Hamid M. Obaidul , Hardy Ian 
Published: November 2021

AbstractThe Association of Southeast Asian Nations (ASEAN) has deployed English not only as its sole working language but also as a tool for forging regional identity, unity and solidarity among its ten member‐states. Drawing on the concept of ‘imagined communities’ and, by extension, ‘imagined identity regionalism’, this article provides a critical examination of this policy desire and asks the question whether the desire should be read as a form of political rhetoric or an achievable goal for ASEAN. We argue that the unifying potential of English language as an imagined regional community and identity has yet to be realised. At best, English can be seen as contributing to ASEAN's ‘functional identity’, rather than a more substantive ‘socio‐cultural identity’. It is suggested that although the birth of a distinct hybridised variety of ASEAN English may facilitate a bottom‐up linguistic identity imagination for ASEAN, such an ideal appears utopian at this time.
Crustal fluids cause strong Lu-Hf fractionation and Hf-Nd-Li isotopic provinciality in the mantle of continental subduction zones
Authors: Gudelius Dominik , Aulbach Sonja , Seitz Hans-Michael , Braga Roberto 
Published: November 2021

Abstract
Metasomatized mantle wedge peridotites exhumed within high-pressure terranes of continental collision zones provide unique insights into crust-mantle interaction and attendant mass transfer, which are critical to our understanding of terrestrial element cycles. Such peridotites occur in high-grade gneisses of the Ulten Zone in the European Alps and record metasomatism by crustal fluids at 330 Ma and high-pressure conditions (2.0 GPa, 850 °C) that caused a transition from coarse-grained, garnet-bearing to fine-grained, amphibole-rich rocks. We explored the effects of crustal fluids on canonically robust Lu-Hf peridotite isotope signatures in comparison with fluid-sensitive trace elements and Nd-Li isotopes. Notably, we found that a Lu-Hf pseudo-isochron is created by a decrease in bulk-rock 176Lu/177Hf from coarse- to fine-grained peridotite that is demonstrably caused by heavy rare earth element (HREE) loss during fluid-assisted, garnet-consuming, amphibole-forming reactions accompanied by enrichment in fluid-mobile elements and the addition of unradiogenic Nd. Despite close spatial relationships, some peridotite lenses record more intense fluid activity that causes complete garnet breakdown and high field strength element (HFSE) addition along with the addition of crust-derived unradiogenic Hf, as well as distinct chromatographic light REE (LREE) fractionation. We suggest that the observed geochemical and isotopic provinciality between peridotite lenses reflects different positions relative to the crustal fluid source at depth. This interpretation is supported by Li isotopes: inferred proximal peridotites show light δ7Li due to strong kinetic Li isotope fractionation (−4.7–2.0‰) that accompanies Li enrichment, whereas distal peridotites show Li contents and δ7Li similar to those of the depleted mantle (1.0–7.2‰). Thus, Earth's mantle can acquire significant Hf-Nd-Li-isotopic heterogeneity during locally variable ingress of crustal fluids in continental subduction zones.
Widespread glasses generated by cometary fireballs during the late Pleistocene in the Atacama Desert, Chile
Authors: Schultz Peter H. , Harris R. Scott , Perroud Sebastián , Blanco Nicolas , Tomlinson Andrew J. 
Published: November 2021

AbstractTwisted and folded silicate glasses (up to 50 cm across) concentrated in certain areas across the Atacama Desert near Pica (northern Chile) indicate nearly simultaneous (seconds to minutes) intense airbursts close to Earth's surface near the end of the Pleistocene. The evidence includes mineral decompositions that require ultrahigh temperatures, dynamic modes of emplacement for the glasses, and entrained meteoritic dust. Thousands of identical meteoritic grains trapped in these glasses show compositions and assemblages that resemble those found exclusively in comets and CI group primitive chondrites. Combined with the broad distribution of the glasses, the Pica glasses provide the first clear evidence for a cometary body (or bodies) exploding at a low altitude. This occurred soon after the arrival of proto-Archaic hunter-gatherers and around the time of rapid climate change in the Southern Hemisphere.