bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmental Sustainability at the President’s Cup: An Eagle or a Double Bogie?
Authors: Pelcher Jamee , Trendafilova Sylvia , Ziakas Vassilios 
Published: October 2021

Over the last decade, researchers have been increasing their studies on the relationship between sport and sustainability. In response, the sport industry has started to recognize the importance of focusing on the natural environment during its operations. Despite the new sustainable intentions of the Professional Golfers’ Association, it is unknown whether the new trajectory in sustainability is being implemented and embraced by fans at all tournaments, specifically those that have unique cultures of their own, such as the President’s Cup. Consequently, this case study provides students with an opportunity to (a) identify major issues and challenges in managing sport events in an environmentally friendly manner, (b) apply sustainable management and pertinent communication practices to the particular context of golf tournaments and facilities, (c) broadly contextualize the complexity of environmental sustainability issues in sport, and (d) create a strategic sustainability plan.
Female authorship of covid-19 research in manuscripts submitted to 11 biomedical journals: cross sectional study
Authors: Gayet-Ageron Angèle , Ben Messaoud Khaoula , Richards Mark , Schroter Sara 
Published: October 2021

AbstractObjectiveTo describe prominent authorship positions held by women and the overall percentage of women co-authoring manuscripts submitted during the covid-19 pandemic compared with the previous two years.DesignCross sectional study.SettingNine specialist and two large general medical journals.PopulationAuthors of research manuscripts submitted between 1 January 2018 and 31 May 2021.Main outcome measuresPrimary outcome: first author’s gender. Secondary outcomes: last and corresponding authors’ gender; number (percentage) of women on authorship byline in “pre-pandemic” period (1 January 2018 to 31 December 2019) and in “covid-19” and “non-covid-19” manuscripts during pandemic.ResultsA total of 63 259 manuscripts were included. The number of female first, last, and corresponding authors respectively were 1313 (37.1%), 996 (27.9%), and 1119 (31.1%) for covid-19 manuscripts (lowest values in Jan-May 2020: 230 (29.4%), 165 (21.1%), and 185 (22.9%)), compared with 8583 (44.9%), 6118 (31.2%), and 7273 (37.3%) for pandemic non-covid-19 manuscripts and 12 724 (46.0%), 8923 (31.4%), and 10 981 (38.9%) for pre-pandemic manuscripts. The adjusted odds ratio of having a female first author in covid-19 manuscripts was <1.00 in all groups (P<0.001) compared with pre-pandemic (lowest in Jan-May 2020: 0.55, 98.75% confidence interval 0.43 to 0.70). The adjusted odds ratio of having a woman as last or corresponding author was significantly lower for covid-19 manuscripts in all time periods (except for the two most recent periods for last author) compared with pre-pandemic (lowest values in Jan-May 2020: 0.74 (0.57 to 0.97) for last and 0.61 (0.49 to 0.77) for corresponding author). The odds ratios for pandemic non-covid-19 manuscripts were not significantly different compared with pre-pandemic manuscripts. The median percentage of female authors on the byline was lower for covid-19 manuscripts (28.6% in Jan-May 2020) compared with pre-pandemic (36.4%) and non-covid-19 pandemic manuscripts (33.3% in Jan-May 2020). Gender disparities in all prominent authorship positions and the proportion of women authors on the byline narrowed in the most recent period (Feb-May 2021) compared with the early pandemic period (Jan-May 2020) and were very similar to values observed for pre-pandemic manuscripts.ConclusionsWomen have been underrepresented as co-authors and in prominent authorship positions in covid-19 research, and this gender disparity needs to be corrected by those involved in academic promotion and awarding of research grants. Women attained some prominent authorship positions equally or more frequently than before the pandemic on non-covid-19 related manuscripts submitted at some time points during the pandemic.
Hypertension as an independent risk factor for severity and mortality in patients with COVID-19: a retrospective study
Authors: Chen Jiankun , Liu Yuntao , Qin Jinying , Ruan Chunyan , Zeng Xianghui , Xu Aiting , Yang Rongyuan , Li Jiqiang , Cai Huayang , Zhang Zhongde 
Published: October 2021

AbstractPurpose of the studyHypertension is one of the most common comorbidities in COVID-19 pneumonia. However, whether it is an independent factor on the severity and mortality of COVID-19 has not been studied.Study designIn this study, 736 patients with a PCR-confirmed diagnosis of COVID-19 were included from 12 January 2020 to 25 March 2020. All patients were divided into two groups according to whether or not they were hypertensive. After propensity score matching (PSM) to remove the interference of mismatches in the baseline data, the clinical characteristics and outcomes of angiotensin II receptor blocker (ARB)/ACE inhibitors application were analysed.ResultsA total of 220 (29.9%) patients were hypertensive, and 516 (70.1%) patients were not hypertensive. PSM eliminated demographic and comorbidity differences between the two groups. Of all participants, 32 patients died (4.3% mortality), including 17 out of 220 in the hypertension group (7.7%) and 15 out of 516 in the non-hypertension group (2.9%). The incidence of intensive care unit (ICU) stay in the hypertension group (12.8%) was higher than in the non-hypertension group (5.3%) (p&lt;0.05). Logistic regression analysis showed that hypertension was an independent risk factor for death, not other comorbidities. Kaplan-Meier analysis showed that mortality was higher in the hypertension group than in the non-hypertension group before and after PSM (p&lt;0.05). There was no statistically significant difference in ICU therapy, mortality and hospitalisation time between hypertensive patients with or without ARBs/ACE inhibitors (p&gt;0.05).ConclusionHypertension was an independent risk factor for the severity and mortality of patients with COVID-19. ARBs/ACE inhibitors should not be discontinued in hypertensive patients with COVID-19.
Do we overtreat patients with presumed neutropenic sepsis?
Authors: King Abbey , Irvine Sharon , McFadyen Angus , Isles Chris 
Published: October 2021

AbstractPurposeMany aspects of the management of neutropenic sepsis remain controversial. These include the choice of empiric antibiotic, the duration of antibiotic therapy and the possibility that very low-risk cases may be managed safely with oral rather than intravenous therapy.Study designRetrospective cohort study conducted in a district general hospital serving a population of 148 000 in south west Scotland.ResultsFifty one patients with cancer, whose neutrophil count was less than 1.0×109/L within 21 days of their last chemotherapy, were admitted as a medical emergency in 2019. All received antibiotic because of presumed neutropenic sepsis. A total of 4 patients had positive blood cultures (group 1), 12 patients had a clinical focus of infection but no clear pathogen (group 2), while 35 patients had neither (group 3). Group 3 patients were more likely to have a solid tumour, less likely to be febrile, had shorter time to neutrophil recovery and higher Multinational Association of Supportive Care in Cancer scores, though not all of these comparisons achieved statistical significance. Median intravenous plus oral antibiotic duration in group 3 patients was 9 days with median hospital stay of 7 days, raising the possibility of overtreatment. Retrospectively, 23 (66%) group 3 patients had MASSC Risk Index greater than 21 suggesting they were at low risk of complications.ConclusionsIt seems likely that many low-risk neutropenic cancer patients with solid tumours could be managed as effectively and as safely with shorter courses of antibiotic, with oral rather than intravenous antibiotic, as outpatients rather than inpatients and with an overall positive impact on antimicrobial stewardship.
Factors associated with symptomatic intracranial haemorrhage after intravenous thrombolysis in severe white matter lesions: a retrospective analysis
Authors: Shen Yu , Li DeFu , Tang BoJi , Cao Qian , Hou Zhuo , Xu LiJun 
Published: October 2021

AbstractBackground and purposeWhite matter lesions (WMLs) are thought to cause damage to the blood–brain barrier, thereby aggravating bleeding after intravenous thrombolysis. However, the risk factors for symptomatic cerebral haemorrhage after thrombolysis are still unclear. This study explored the risk factors for bleeding in patients with severe WMLs after intravenous thrombolysis to prevent bleeding as soon as possible.MethodsA large single-centre observational study conducted a retrospective analysis of intravenous thrombolysis in patients with severe WMLs from January 2018 to March 2021. According to whether symptomatic cerebral haemorrhage occurred, the patients were divided into two groups, and then statistical analysis was performed.ResultsAfter a retrospective analysis of the data of nearly 1000 patients with intravenous thrombolysis and excluding invalid information, 146 patients were included, of which 23 (15.8%) patients had symptomatic cerebral haemorrhage. Univariate analysis showed that a history of hypertension (20% vs 4.9%, p=0.024), hyperlipidaemia (38.7% vs 9.6%, p&lt;0.001), the National Institutes of Health Stroke Scale (NIHSS) score before thrombolysis (median 17 vs 6, p&lt;0.001), low-density lipoprotein levels (median 2.98 vs 2.44, p=0.011), cholesterol levels (mean 4.74 vs 4.22, p=0.033), platelet count (median 161 vs 191, p=0.031), platelet distribution width (median 15.2 vs 12.1, p=0.001) and sodium ion levels (median 139.81 vs 138.67, p=0.043) were significantly associated with symptomatic cerebral haemorrhage. Further multivariate logistic regression analysis showed that hyperlipidaemia (OR=9.069; 95% CI 2.57 to 32.07; p=0.001) and the NIHSS score before thrombolysis (OR=1.33; 95% CI 1.16 to 1.52; p&lt;0.001) were comprehensive risk factors for symptomatic cerebral haemorrhage.ConclusionHyperlipidaemia and the NIHSS score before thrombolysis are independent risk factors for bleeding after intravenous thrombolysis in patients with severe WMLs. Delaying the onset of white matter and preventing risk factors for bleeding will help improve the prognosis of cerebral infarction and reduce mortality. These risk factors need to be further evaluated in future studies.
A characterization of graded pseudo-valuation domains
Authors: Ahmed Malik Tusif , Bakkari Chahrazade , Mahdou Najib , Riffi Abdelkbir 
Published: October 2021

Let [Formula: see text] be a torsionless grading monoid, [Formula: see text] a [Formula: see text]-graded integral domain, H the set of nonzero homogeneous elements of R, K the quotient field of [Formula: see text] and [Formula: see text] the group of units of [Formula: see text]. We say that R is a graded pseudo-valuation domain (gr-PVD) if whenever a homogeneous prime ideal P of R contains the product xy of two homogeneous elements of [Formula: see text], then [Formula: see text] or [Formula: see text]. The notion of gr-PVDs was introduced recently by the authors in (M. T. Ahmed, C. Bakkari, N. Mahdou and A. Riffi, Graded pseudo-valuation domains, Comm. Algebra 48 (2020) 4555–4568) as a graded version of pseudo-valuation domains (PVDs). In this paper, we show that R is a gr-PVD if and only if exactly one of the following two conditions holds : (1) (a) [Formula: see text], (b) [Formula: see text] is a pseudo-valuation monoid, and (c) [Formula: see text] for every [Formula: see text] whenever [Formula: see text] is not a unit. (2) (a) [Formula: see text], (b) [Formula: see text] is a valuation monoid, (c) [Formula: see text] for every [Formula: see text] whenever [Formula: see text] is not a unit, and (d) [Formula: see text] is a gr-PVD.
Computed Tomography Image under Three-Dimensional Reconstruction Algorithm Based in Diagnosis of Renal Tumors and Retroperitoneal Laparoscopic Partial Nephrectomy
Authors: Zhang Haijie , Yin Fu , Yang Liyang , Qi Anqi , Cui Weiwei , Yang Shanshan , Wen Ge 
Published: October 2021

This study was to explore the clinical application value of computed tomography (CT) images based on a three-dimensional (3D) reconstruction algorithm for laparoscopic partial nephrectomy (LPN) in patients with renal tumors. 30 cases of renal cell carcinoma (RCC) patients admitted to the hospital were selected as the research objects and were rolled into two groups using a random table method. The patients who received PLN under the three-dimensional reconstruction and laparoscopic technique were included in the experimental group (group A), and the patients who received LPN using CT images only were included in the control group (group B). In addition, the treatment results of the two groups of patients were compared and analyzed. Results. The effective rate of the established model was 93.3%; the total renal arteriovenous variability of group A (13.3%) was higher than that of group B (6.7%), and the operation time (131.5 ± 32.1 minutes) was much lower than that of group B (158.7 ± 36.2 minutes), showing statistical significance (

P

< 0.05). Conclusion. CT images based on 3D reconstruction algorithms had high clinical application value for LPN in patients with renal tumors, which could improve the efficiency and safety of LPN.
A Randomized Phase II Study of Anti-CSF1 Monoclonal Antibody Lacnotuzumab (MCS110) Combined with Gemcitabine and Carboplatin in Advanced Triple-Negative Breast Cancer
Authors: Kuemmel Sherko , Campone Mario , Loirat Delphine , Lopez Rafael Lopez , Beck J. Thaddeus , De Laurentiis Michelino , Im Seock-Ah , Kim Sung-Bae , Kwong Ava , Steger Guenther G. , Adelantado Esther Zamora , Duhoux Francois P. , Greil Richard , Kuter Irene , Lu Yen-Shen , Tibau Ariadna , Özgüroğlu Mustafa , Scholz Christian W. , Singer Christian F. , Vega Estela , Wimberger Pauline , Zamagni Claudio , Couillebault Xuan-Mai , Fan Liqiong , Guerreiro Nelson , Mataraza Jennifer , Sand-Dejmek Janna , Chan Arlene 
Published: October 2021

Abstract

Purpose:
This phase II study determined the efficacy of lacnotuzumab added to gemcitabine plus carboplatin (gem-carbo) in patients with advanced triple-negative breast cancer (TNBC).

Patients and Methods:
Female patients with advanced TNBC, with high levels of tumor-associated macrophages not amenable to curative treatment by surgery or radiotherapy were enrolled. Lacnotuzumab was dosed at 10 mg/kg every 3 weeks, ± a dose on cycle 1, day 8. Gemcitabine (1,000 mg/m2) and carboplatin (dose in mg calculated by area under the curve [mg/mL/min] × (glomerular filtration rate [mL/min] + 25 [mL/min]) were dosed every 3 weeks. Treatment continued until unacceptable toxicity, disease progression, or discontinuation by physician/patient.

Results:
Patients received lacnotuzumab + gem-carbo (n = 34) or gem-carbo (n = 15). Enrollment was halted due to recruitment challenges owing to rapid evolution of the therapeutic landscape; formal hypothesis testing of the primary endpoint was therefore not performed. Median progression-free survival was 5.6 months [90% confidence interval (CI), 4.47–8.64] in the lacnotuzumab + gem-carbo arm and 5.5 months (90% CI, 3.45–7.46) in the gem-carbo arm. Hematologic adverse events were common in both treatment arms; however, patients treated with lacnotuzumab experienced more frequent aspartate aminotransferase, alanine aminotransferase, and creatine kinase elevations. Pharmacokinetic results showed that free lacnotuzumab at 10 mg/kg exhibited a typical IgG pharmacokinetic profile and target engagement of circulating colony-stimulating factor 1 ligand.

Conclusions:
Despite successful target engagement and anticipated pharmacokinetic profile, lacnotuzumab + gem-carbo showed comparable antitumor activity to gem-carbo alone, with slightly poorer tolerability. However, the data presented in this article would be informative for future studies testing agents targeting the CSF1–CSF1 receptor pathway in TNBC.
The Spatial Context of Tumor-Infiltrating Immune Cells Associates with Improved Ovarian Cancer Survival
Authors: Steinhart Benjamin , Jordan Kimberly R. , Bapat Jaidev , Post Miriam D. , Brubaker Lindsay W. , Bitler Benjamin G. , Wrobel Julia 
Published: October 2021

Abstract

Ovarian cancer is the deadliest gynecologic malignancy. Multi-omics techniques have provided a platform for improved predictive modeling of therapy response and patient outcomes. While high-grade serous carcinoma (HGSOC) tumors are immunogenic and numerous studies have defined positive correlation to immune cell infiltration, immunotherapies in clinical trials have exhibited low efficacy rates. There is a significant need to better comprehend the role and composition of immune cells in mediating ovarian cancer therapeutic response and progression. We performed multiplex IHC with an HGSOC tissue microarray (n = 127) to characterize the immune cell composition within tumors. After analyzing the composition and spatial context of T cells (CD4/CD8), macrophages (CD68), and B cells (CD19) within the tumor, we found that increased B-cell and CD4 T-cell presence correlated with overall survival. More importantly, we observed that the proximity between tumor-associated macrophages and B cells or CD4 T cells significantly correlated with overall survival.

Implications:
The results highlight the antitumor role of B cells and CD4 T cells, and that the spatial interactions between immune cell types are a novel predictor of therapeutic response and patient outcomes.
Subintimal Versus Intraluminal Approach for Femoropopliteal Chronic Total Occlusions Treated With Intravascular Ultrasound Guidance
Authors: Tomoi Yusuke , Takahara Mitsuyoshi , Kuramitsu Shoichi , Soga Yoshimitsu , Iida Osamu , Fujihara Masahiko , Kawasaki Daizo , Ando Kenji ,   the IVORY Study Investigators
Published: October 2021

Background
The subintimal approach (SA) is widely used in endovascular therapy for femoropopliteal chronic total occlusion lesions. However, when compared with the intraluminal approach (IA), the safety and efficacy of SA in real‐world practice are not well characterized. Furthermore, there is a paucity of data on the clinical impact of subintimal and intraluminal wire passage (SWP and IWP, respectively) assessed by intravascular ultrasound.

Methods and Results

From the IVORY (Intravascular Ultrasound‐Supported Endovascular Therapy in Superficial Femoral Artery) registry, this study included 500 patients undergoing endovascular therapy for femoropopliteal chronic total occlusion lesions (SA, n=67; IA, n=433; and SWP, n=186; IWP, n=314). The primary end point was the cumulative 1‐year incidence of restenosis. The rate of perioperative complications was also assessed. Propensity score matching analysis was performed to adjust for the intergroup differences. After propensity score matching, the final study population consisted of 59 pairs (SA, n=59; IA, n=348) and 170 pairs (SWP, n=170; IWP, n=293), respectively. Cumulative 1‐year incidence of restenosis was comparable between the SA and IA groups (41.0% versus 43.4%,
P
=0.40). No significant difference in 1‐year restenosis rate between the SWP and IWP groups was observed (48.2% versus 40.8%,
P
=0.40), although the SWP group tended to be a higher rate of perioperative complications than the IWP group (8.2% versus 4.1%,
P
=0.07).

Conclusions
At 1 year, both SA and IA showed acceptable results for femoropopliteal chronic total occlusion lesions. Cumulative 1‐year incidence of restenosis was not significantly different between SWP and IWP, whereas perioperative complications occurred more frequently in SWP than in IWP.

Registration

URL:
https://www.umin.ac.jp
; Unique identifier: UMIN000020472.
Sexually dimorphic skin glands in the invasive species Lithobates catesbeianus (Anura: Ranidae)
Authors: Mancinelli Sofia Agustina Maria , Cóceres Araceli Rita , Pozzi Andrea Gabriela , Jungblut Lucas David 
Published: October 2021

Abstract
Males of most amphibian species possess specialized cutaneous glands, known as sexually dimorphic skin glands (SDSGs). SDSGs are usually clustered in specific body regions and are externally visible, but in some cases, external differences between males and females can be slight or absent, and the occurrence of SDSGs can only be disclosed by histological studies. Chemical signals produced by SDSGs markedly affect amphibian behaviour and reproduction, and therefore their occurrence, features, and location in the body could provide information on potential mechanisms of intraspecific communication in a particular species. In the present study, we perform light microscope (both histological and histochemical), and scanning electron microscope studies of skin samples from male and female adult specimens of the invasive bullfrog Lithobates catesbeianus, covering several body regions that could hold SDSGs. Most skin areas analysed showed only ordinary granular and mucous glands despite remarkable sexual dimorphism that could be externally observed. By contrast, the male nuptial pads contained exclusively SDSGs that were hypertrophied specialized mucous glands (SMGs), closely resembling breeding glands described in other anurans. Our histochemical study revealed that these SMGs contain heterogeneous populations of secretory cells, possibly involved in pheromone production. We discuss these characteristics of the SDSGs found in L. catesbeianus, as well as the surface specialization of the nuptial pads (achieved by scanning electron microscopy) in the light of their potential role in the chemical communication in this invasive species.
Humic acid – a potential bioresource for nematode control
Authors: Nagachandrabose Seenivasan , Baidoo Richard 
Published: October 2021

Summary
There is a growing interest in the use of natural products for crop production and protection. Humic acid is a well-known bioresource that intensifies soil functions and improves crop productivity. This review article provides a synopsis of the humic acid-plant-nematode association and the prospects for using humic acid as an alternative to chemical control of nematodes. Humic acid is known to have toxic and antagonistic effects against many plant-parasitic nematodes, including Meloidogyne spp., Rotylenchulus reniformis, Radopholus similis and Helicotylenchus multicinctus. The required dose for getting significant nematode control ranges from 0.04 to 2.0% concentration. Delivery methods like soil application or drenching, seedling root dip treatment and foliar spray on leaves are effective for nematode control. Humic acid controls plant-parasitic nematodes through various mechanisms including killing juveniles, inhibiting hatching, reducing nematode infectivity and reproduction, and inducing systemic resistance. Humic acid is compatible with bio-inoculants such as Azospirillum spp., phosphobacterium, Bacillus megaterium, Pseudomonas fluorescens, Trichoderma viride, Glomus spp., Pochonia chlamydosporia, Purpureocillium lilacinum and T. asperellum. These attributes of humic acid show a promising potential for use in nematode control. However, further work on bio-efficacy against a broad spectrum of plant-parasitic nematodes is needed.