bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pola Komunikasi Komunitas Tradwife di Eropa, Amerika Serikat, Australia dalam Era Digital Media
Authors: Wahyuning Lintas Utami  
Published: January 2025

Artikel ini membahas mengenai komunitas traditional wife, sebuah komunitas perempuan atau isteri yang mengedepankan nilai nilai kehidupan dengan standard norma fungsi sosial perempuan di tahun 1959 yang memposisikan diri sebagai perempuan yang berada pada ruang ruang domestik, mendedikasikan diri utk berfungsinya sebuah keluarga , menempatkan suami sebagai Bread Winner.Pada masa saat ini banyak perempuan dalam rumah tangganya juga berperan sebagai Bread Winner dalam rangka mencukupi kebutuhan keluarga. Namun juga ada perempuan yang merindukan peran peran domestiknya seperti peran sosial perempuan di tahun 1959 yang berfokus pada ruang domestik yang terkait dengan pemenuhan fungsi – fungsi home maker dalam rumah tangga. Artikel ini ingin mencari tahu mengapa di era yang segala sesuatu di ukur dengan nilai nilai materialistik kemudian malah berbalik memunculkan komunitas perempuan yang tidak terlalu mengejar pencapaian yang bersifat materialistik, namun lebih memilih memaksimalkan fungsi – fungsinya di ruang domestik yang lebih privat. Komunitas ini mengikuti perkembangan teknologi informasi dengan saling berinteraksi di dunia media sosial seperti website dan instagram. Para perempuan di komunitas traditional wife menempatkan diri pada posisi dalam hal bekerja memperoleh manfaat finansial sebagai sebuah aktualisasi diri, bukan sebuah peran yang menjadi kewajiban dalam rumah tangganya. Artikel ini di tulis melalui metode penelitian kualitatif intepretatif dengan studi pustaka,observasi instagram,website dan wawancara terhadap akademisi yang memiliki spesifikasi pada issue issue perempuan dan gender juga mewawancarai perempuan indonesia yang telah lebih dari 5 tahun tinggal di Kanada. Artikel ini ditulis dengan menggunakan metode kualitatif deskriptif, artikel ini juga menyajikan beberapa fakta terkait fenomena Traditional Wife yang di pandang secara positif, sedangkan sisi negatifnya dianggap sebagai promosi terhadap isu rasial yang mengunggulkan ras kulit putih.
Efektivitas Daun Pandan (Pandanus amaryllifolius) , Daun Sereh (Cymbopogon ciratus), Dan Cengkeh (Syzygium aromaticum) Sebagai Penolak Lalat
Authors: Novarianti  
Published: January 2025

Latar Belakang : Salah satu agen utama dalam penyebaran sejumlah penyakit menular mekanis, termasuk kolera, tipus, kolera, disentri, dan penyakit saluran pencernaan lainnya, adalah lalat. Mengontrol vektor lalat diperlukan karena ini. Memanfaatkan zat aktif yang diperoleh dari tumbuhan atau dari tanaman yang dapat berperan sebagai modal utama untuk mengendalikan vektor, seperti cengkeh, pandan, dan daun serai. Tujuan : Tujuan penelitian mengetahui efektivitas Daun Pandan, Daun Sereh dan Cengkeh dalam menolak Lalat. Metode : Jenis penelitian yang digunakan adalah eksperimen. Dengan Desain penelitian Posttest Only With Control Design. Total Lalat uji yang digunakan yaitu sebanyak 400 ekor dengan 3 perlakuan dan 5 kali pengulangan, teknk pengambilan data primer diperoleh dari hasil uji yang dilakukan sedangkan data sekunder doperoleh dari berbagai sumber referensi yang terkait. Penelitian ini dilaksanakan pada bulan oktober serta analisa data dilakukan dengan Annlisa of Variance (Uji ANNOVA) untuk membandingkan Efektivitas lalat berdasarkan bahan daun pandan, daun sereh, dan cengkeh. Hasil : pada dosis 9 gram daya tolak daun pandan sebanyak 34%, daun sereh sebanyak 74%, cengkeh sebanyak 58%. hasil test of homogeneity of variances di dapatkan hasil nilai sig 0,052 yang artinya lebih besar dari 0,05 maka dapat diartikan bahwa hipotesis 0 (Hₒ ) di tolak yang dapat diartikan sebagai uji coba pada daun pandan,daun sereh,dan cengkeh adalah sama (homogeny). Kesimpulan : bahwa yang efektif dalam menolak lalat yaitu daun sereh. Saran untuk masyarakat jika ingin menggunakan bahan daun pandan dan cengkeh sebagai penolak lalat sebaiknya jumlah dosis yang digunakan ditambahkan lagi agar bahan tersebut mampu menolak lalat.
Gut microbial composition associated with risk of premature aging in women with Yin-deficiency constitution
Authors: Zhai Yingying , Li Jing , Cao Yanqi , Li Yufei , Bao Xuejie , Liang Jinfeng , Liu Qi , Xia Yifan , Yu Ruoxi 
Published: January 2025

BackgroundYin-deficiency constitution (YinDC) refers to a traditional Chinese medicine concept, characterized by an imbalance state that includes an imbalance in the gut microbiota, resulting from a relative deficiency of Yin fluids within the body. In recent years, it has become apparent that the composition and structure of the gut microbiota play a significant role in the aging process. The imbalance of gut microbiota in YinDC may accelerate the aging process. However, the specific gut microbiota compositions involved in the YinDC premature aging process remain unknown.MethodsIn this study, we conducted a cohort study including 60 women with YinDC and BC to analyze their gut microbiota composition. We integrated 16S rDNA sequencing with machine learning methods to reveal the association between gut microbiota and premature aging in YinDC women.ResultsWe found a significant difference in the composition of gut microbiota between the YinDC and the BC group. At the phylum level, Cyanobacteria and Synerobacteria only emerged in the YinDC group. At the genus level, Bacteroides, Bifidobacterium, Haemophilus, Alistipes, and Dialister showed higher abundance in the YinDC group. Bilophila, Eubacterium, and Aeromonas were the most significant indicators influencing the YinDC premature aging. The YinDC group had the most functional gene pathways associated with the metabolism.ConclusionOur study demonstrated that the gut microbiota was associated with premature aging in women with YinDC, potentially providing preliminary evidence and guidance for personalized anti-aging strategies.
Exploring family models and SDG number five in picture books. Dialogical alternatives for secondary education
Authors: López-Valero Amando , Hernández-Delgado Lourdes , Jerez-Martínez Isabel , Encabo-Fernández Eduardo 
Published: January 2025

IntroductionThis contribution addresses the controversy that often surrounds the educational treatment of new family models. The literature, as a medium of fiction based on reality, reflects social changes, including the organization of families. Promoting gender equality—Sustainable Development Goal (SDG) number five (United Nations)—is closely linked to understanding these new family structures. In this context, picture books—powerful literary resources that combine images and words—should be used to expose students to new realities and raise awareness of diversity, thereby fostering tolerance and respect.MethodThis study analyzes several picture books, including classics like King and King and more recent titles like Well done Mummy. The analysis will focus on their format and content to determine their suitability for secondary school classrooms, discuss family models, and raise awareness, potentially changing attitudes. Following the analysis, we explore how to incorporate these books into educational sequences, highlighting the use of dialogical discussions to promote critical thinking.ResultsThe results of this contribution will include a list of suggested picture books, an evaluation of their suitability, and proposed didactic strategies.DiscussionThese aspects will strengthen the classroom treatment of this controversial topic, helping students grow holistically through axiological aspects and the development of SDG number five: gender equality. Additionally, this study will confirm the relevance of using picture books in the classroom within the context of liquid modernity, where audiovisual elements are key motivators for students.
Hybrid MPPT control using hybrid pelican optimization algorithm with perturb and observe for PV connected grid
Authors: Abdullah Burhan U. Din , Dhar Suman Lata , Jaiswal Shiva Pujan , Gulzar Muhammad Majid , Alqahtani Mohammad , Khalid Muhammad 
Published: January 2025

IntroductionPhotovoltaic systems offer immense potential as a future energy source, yet maximizing their efficiency presents challenges, notably in achieving optimal voltage due to their nonlinear behavior. Operating current and voltage fluctuations, driven by temperature and radiation changes, significantly impact power output. Traditional Maximum Power Point Tracking (MPPT) methods struggle to adapt accurately to these dynamic environmental conditions. While Artificial Intelligence (AI) and optimization techniques show promise, their implementation complexity and longer attainment times for Maximum Power Point (MPP) hinder widespread adoption.MethodThis paper proposes a hybrid MPPT technique that integrates the Pelican Optimization algorithm (POA) with the Perturb and Observe algorithm (P&amp;O) for a grid-connected photovoltaic system (PV). The proposed technique consists of two loops: PO as the reference point setting loop (inner loop) and POA as a fine-tuning (outer)loop. The combination of inner and outer loops minimizes oscillations by adjusting the perturbation direction and enhancing the convergence speed of the MPPT.Results and DiscussionTo validate the efficacy of the proposed MPPT technique for different environmental conditions, a comprehensive comparison is conducted between the proposed hybrid pelican and perturb and observe (HPPO) technique and other MPPT algorithms. The proposed technique has optimized PV and grid outputs with an MPPT efficiency of 99%, best tracking speed, and total harmonic distortion (THD) for all conditions below 5% agree with IEEE 519 standards.
Association between METTL14 gene polymorphisms and risk of ovarian endometriosis
Authors: Zhou Zijun , Jie Youkun , Hu Xianyue , Chen Guange , Bao Yanjing , OuYang Zhenbo , Wu Liangzhi , Gao Tianyang , Zhang Qiushi , Hua Wenfeng 
Published: January 2025

BackgroundEndometriosis, a prevalent chronic gynecological condition, is frequently associated with infertility and pelvic pain. Despite numerous studies indicating a correlation between epigenetic regulation and endometriosis, its precise genetic etiology remains elusive. Methyltransferase-like 14 (METTL14), a crucial component of the N6-methyladenosine (m6A) RNA methyltransferase complex and an RNA binding scaffold, is known to play a pivotal role in various human diseases. The possibility that single nucleotide polymorphisms (SNPs) in the METTL14 gene contribute to susceptibility of endometriosis has not been thoroughly investigated.MethodsWe assessed the genotype frequencies of five potential functional METTL14 SNPs (rs298982 G&gt;A, rs62328061A&gt;G, rs9884978G&gt;A, rs4834698C&gt;T, and rs1064034A&gt;T) in a Chinese population consisting of 458 patients with ovarian endometriosis and 462 healthy controls. We employed unconditional logistic regression and stratified analyses to evaluate their genotypic associations with the risk of ovarian endometriosis.ResultsAmong the five SNPs examined, we found that the rs298982 A allele was significantly associated with increased risk, whereas the rs62328061 G allele was linked to a decreased risk of ovarian endometriosis. Individuals harboring two unfavorable genotypes demonstrated a significantly elevated risk of ovarian endometriosis (adjusted odds ratio (AOR) = 1.57, 95% confidence interval (CI) = 1.16–2.13, P = 0.004) compared with those with no risk genotypes. Stratified analysis revealed the risk effect of rs298982 GA/AA genotypes in the gravidity≤1, parity≤1, rASRM stage I, and rASRM stage II + III + IVsubgroups. Haplotype analysis showed that individuals with the GATAA haplotype were at higher risk of ovarian endometriosis (AOR = 5.54, 95% CI = 1.63–18.87, P = 0.006), whereas the AGTTG haplotype exhibited protective effects (AOR = 0.55, 95% CI = 0.31–0.97, P = 0.039) compared with wild-type GACAG haplotype carriers. Additionally, Bayesian false discovery probability and false positive report probability analysis confirmed the robustness of the significant findings. Expression quantitative trait loci analysis revealed a significant association between the rs9884978 GA/AA genotypes and elevated METTL14 mRNA levels in fibroblasts and adrenal gland. Conversely, the rs298982 GA/GG genotypes were significantly associated with reduced METTL14 mRNA levels in the nucleus accumbens and frontal cortex.ConclusionOur results demonstrate that METTL14 polymorphisms are associated with susceptibility to ovarian endometriosis among Chinese women.
Case report: Rituximab combined with plasma exchange treatment for systemic lupus erythematosus complicated with thrombotic microangiopathy and non-cirrhotic portal hypertension
Authors: Huang Jinmei , Fan Wei , Chen Xuyan , Wu Shufan , Dong Zhigao , Zhang Yi , Lin Yiwan , Xiao Pingping 
Published: January 2025

IntroductionSystemic lupus erythematosus (SLE) complicated by thrombotic microangiopathy (TMA) and non-cirrhotic portal hypertension (NCPH) is rare. We present a case of a female patient with SLE who developed TMA and NCPH and responded positively to rituximab and plasma exchange treatment.Case descriptionA 53-year-old woman was admitted with 6 h of confusion. Upon admission, she was diagnosed with SLE complicated by lupus encephalopathy, blood system impairment, cardiomyopathy, and nephritis. Initial treatment with high-dose methylprednisolone, immunoglobulin shock therapy, and tacrolimus (1 mg, twice daily) improved her symptoms and laboratory indicators. However, after a pulmonary infection and infection with the 2019 novel coronavirus, the patient’s condition deteriorated further. She experienced confusion and a delayed response. Hemoglobin levels and platelet counts decreased, lactate dehydrogenase and creatinine levels increased, and the percentage of peripheral schistocytes was approximately 6.5%. Abdominal ultrasonography revealed a substantial amount of ascites, diffuse liver lesions, splenomegaly, and splenic varices. Enhanced computed tomography revealed diffuse liver disease along the portal veins, intrahepatic lymphatic dilatation, esophageal and gastric varices, a splenorenal vein shunt, and splenomegaly. The patient was negative for hepatitis virus, autoimmune liver disease antibodies, ceruloplasmin, and tumor markers. Therefore, SLE complicated by TMA and NCPH was considered. She was treated with high-dose methylprednisolone (500 mg) for 3 days and immunoglobulin (0.4 g/kg/day) for 5 days, followed by rituximab (500 mg) for suppressive immunotherapy combined with plasma exchange (seven times), low-molecular-weight heparin (5,000 U every 12 h) for anticoagulation, and a diuretic. The patient’s symptoms and laboratory indicators improved.ConclusionThis case suggests that a combination of rituximab, plasma exchange, anticoagulation, and diuretics may be an effective treatment for patients with SLE complicated by TMA and NCPH.
S6P mutation in Delta and Omicron variant spike protein significantly enhances the efficacy of mRNA COVID-19 vaccines
Authors: Bong Yong-Sik , Brown David , Chung Ezra , Ananthaswamy Neeti , Chen Renxiang , Lewoczko Evan , Sabbers William , Patterson-Orazem Athéna C. , Dorsey Zachary , Zou Yiqing , Yu Xue , Liang Jiening , He Jiaxi , Long Steven , Shen Dong 
Published: January 2025

BackgroundThe unrelenting emergence of SARS-CoV-2 variants has significantly challenged the efficacy of existing COVID-19 vaccines. Enhancing the stability and immunogenicity of the spike protein is critical for improving vaccine performance and addressing variant-driven immune evasion.MethodsWe developed an mRNA-based vaccine, RV-1730, encoding the Delta variant spike protein with the S6P mutation to enhance stability and immunogenicity. The vaccine’s immunogenicity and protective efficacy were evaluated in preclinical models, including monovalent (RV-1730) and bivalent (RV-1731) formulations targeting the Delta and BA.1 variants. Additionally, the effectiveness of RV-1730 as a heterologous booster following primary vaccination with BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna-NIAID) was assessed.ResultsRV-1730 elicited significantly stronger B and T cell responses and more durable neutralizing antibodies compared to S2P-based vaccines. The bivalent RV-1731 vaccine demonstrated broad neutralizing activity against emerging variants, including XBB1.5 and JN.1. Importantly, RV-1730, when used as a heterologous booster following initial immunization with BNT162b2 or mRNA-1273, significantly enhanced neutralizing antibody titers against multiple variants, including Delta and Omicron. Both RV-1730 and RV-1731 provided superior protection in preclinical models, indicating enhanced efficacy due to the S6P mutation.ConclusionThe incorporation of the S6P mutation into the Delta variant spike protein significantly enhances the immunogenicity and efficacy of mRNA-based COVID-19 vaccines. The strong performance of RV-1730 as a heterologous booster and the broad-spectrum activity of the bivalent RV-1731 vaccine underscore their potential as versatile and effective vaccination strategies against SARS-CoV-2 and its evolving variants.
Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing
Authors: Jiang Yafeng , Hu Zhaolan , Huang Roujie , Ho Kaying , Wang Pengfei , Kang Jin 
Published: January 2025

BackgroundAnti-citrullinated peptide antibodies (ACPA)-negative (ACPA−) rheumatoid arthritis (RA) presents significant diagnostic and therapeutic challenges due to the absence of specific biomarkers, underscoring the need to elucidate its distinctive cellular and metabolic profiles for more targeted interventions.MethodsSingle-cell RNA sequencing data from peripheral blood mononuclear cells (PBMCs) and synovial tissues of patients with ACPA− and ACPA+ RA, as well as healthy controls, were analyzed. Immune cell populations were classified based on clustering and marker gene expression, with pseudotime trajectory analysis, weighted gene co-expression network analysis (WGCNA), and transcription factor network inference providing further insights. Cell-cell communication was explored using CellChat and MEBOCOST, while scFEA enabled metabolic flux estimation. A neural network model incorporating key genes was constructed to differentiate patients with ACPA− RA from healthy controls.ResultsPatients with ACPA− RA demonstrated a pronounced increase in classical monocytes in PBMCs and C1QChigh macrophages (p &lt; 0.001 and p &lt; 0.05). Synovial macrophages exhibited increased heterogeneity and were enriched in distinct metabolic pathways, including complement cascades and glutathione metabolism. The neural network model achieved reliable differentiation between patients with ACPA− RA and healthy controls (AUC = 0.81). CellChat analysis identified CD45 and CCL5 as key pathways facilitating macrophage-monocyte interactions in ACPA− RA, prominently involving iron-mediated metabolite communication. Metabolic flux analysis indicated elevated beta-alanine and glutathione metabolism in ACPA− RA macrophages.ConclusionThese findings underscore that ACPA-negative rheumatoid arthritis is marked by elevated classical monocytes in circulation and metabolic reprogramming of synovial macrophages, particularly in complement cascade and glutathione metabolism pathways. By integrating single-cell RNA sequencing with machine learning, this study established a neural network model that robustly differentiates patients with ACPA− RA from healthy controls, highlighting promising diagnostic biomarkers and therapeutic targets centered on immune cell metabolism.
The combined evaluation of preoperative serum CEA and postoperative tissue CEA as a prognostic factor in stages 0–IV colorectal cancer: a retrospective cohort study
Authors: Tong Guojun , Li Hui , Shen Yan , Tan Zhenhua , Qian Hai 
Published: January 2025

BackgroundThe roles of preoperative serum carcinoembryonic antigen (sCEA) and postoperative tissue carcinoembryonic antigen (tCEA) have been extensively studied in isolation in colorectal cancer (CRC). However, the combined role of sCEA and tCEA remains inadequately described.MethodsA total of 1,757 retrospective cases of stage 0–IV CRC from January 2006 to January 2016 in our institution were included. Clinicopathological features and follow-up data were collected. Stage 0 was combined with stage I. sCEA levels were classified as normal or high (&gt;10 ng/mL), while tCEA levels were categorised into three grades (+, ++, and +++). This resulted in six combined groups (2 × 3). ANOVA and cross-tabulation were employed to analyse continuous and categorical data, respectively. Univariate and multivariate analyses were conducted using Cox regression. All data were analysed using SPSS 27 and R 4.3.1.ResultsSome clinicopathologic features differed significantly among the combined CEA test groups (all p &lt; 0.05). The receiver operating characteristic (ROC) curves for sCEA, tCEA, and combined CEA exhibited significant differences in five-year OS with death as the input variable (all p &lt; 0.05). The area under the curve (AUC) for combined CEA was the highest, indicating the value of this study. Cox regression analysis demonstrated that tumour location, T stage, differentiation, chemotherapy, TNM stage, tCEA, and combined CEA were significant in the univariate analysis; however, tCEA was not significant (p = 0.096) in the multivariate analysis among these seven variables. Five-year OS analysis revealed that sCEA, tCEA, and combined CEA were not significant in stages 0 &amp; I–II (all p &gt; 0.05) but were significant in stages III–IV (all p &lt; 0.05), except for tCEA in stage IV (p = 0.24) as per K–M and univariate analysis. No significant difference was observed between sCEA and tCEA (p = 0.55, 0.095), whereas combined CEA demonstrated a significant difference (p &lt; 0.001) in both univariate and multivariate analyses.ConclusionsCEA, tCEA, and combined CEA exhibit prognostic roles in stages III–IV of CRC, with only combined CEA serving as an independent factor in these stages.