bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic profiling of the oncogenic septin 9 reveals isoform‐specific interactions in breast cancer cells
Authors: Devlin Louis , Okletey Joshua , Perkins George , Bowen Jonathan R. , Nakos Konstantinos , Montagna Cristina , Spiliotis Elias T. 
Published: August 2021

AbstractSeptins are a family of multimeric GTP‐binding proteins, which are abnormally expressed in cancer. Septin 9 (SEPT9) is an essential and ubiquitously expressed septin with multiple isoforms, which have differential expression patterns and effects in breast cancer cells. It is unknown, however, if SEPT9 isoforms associate with different molecular networks and functions. Here, we performed a proteomic screen in MCF‐7 breast cancer cells to identify the interactome of GFP‐SEPT9 isoforms 1, 4 and 5, which vary significantly in their N‐terminal extensions. While all three isoforms associated with SEPT2 and SEPT7, the truncated SEPT9_i4 and SEPT9_i5 interacted with septins of the SEPT6 group more promiscuously than SEPT9_i1, which bound predominately SEPT8. Spatial mapping and functional clustering of non‐septin partners showed isoform‐specific differences in interactions with proteins of distinct subcellular organelles (e.g., nuclei, centrosomes, cilia) and functions such as cell signalling and ubiquitination. The interactome of the full length SEPT9_i1 was more enriched in cytoskeletal regulators, while the truncated SEPT9_i4 and SEPT9_i5 exhibited preferential and isoform‐specific interactions with nuclear, signalling, and ubiquitinating proteins. These data provide evidence for isoform‐specific interactions, which arise from truncations in the N‐terminal extensions of SEPT9, and point to novel roles in the pathogenesis of breast cancer.
Construction of a Novel Barium‐Free Green‐Light Emitting Illuminant Based on Boron Carbide
Authors: Huang Zhiping , Xu Shengliang , Chen Xinli , Wang Min , Yuan Hua , Zhao Huali , Zhang Yuanyuan 
Published: August 2021

AbstractGreen‐light emitting illuminant and green pearls that are currently being used for pyrotechnics are mainly composed of barium carbonate and polyvinyl chloride (PVC), which lead inevitably to the substantial generation of abundant harmful products for environmental pollution. There is thus considerable scope for the development of a novel emitting illuminant with an improved “green” composition instead of compositions incorporating barium based oxidants and polyvinyl chloride for environmental protection. For this purpose, a new composition composed of boron carbide, potassium perchlorate, and guanidine nitrate with a suitable burning rate of 5∼15 mm/s required for fireworks, the high luminous intensity of 34665 Cd and spectral purity of 67.1 % at a primary wavelength of 562 nm was developed. Notably, PM10 data demonstrated that the new composition generated less than half the amount of the smoke relative to the original one. More importantly, all of the safety parameters of this new formulation meet well with the standards’ requirements, i. e., a remarkable low sensitivity to friction (0 %) and impact (8 %), relative stability to electric discharge (374.4 mJ), flame (14.0 cm) and heating (unburned, unexploded at 75 °C for 48 h), as well as a high ignition temperature of 504.0 °C and a low moisture absorption rate (0.66 %). Taken together, the new emitting illuminant developed herein showed great potential to be used for fireworks and signal flare in both military and civilian applications.
Investigation of the Impurities in Erythritol Tetranitrate (ETN) Using UHPLC‐QTOF
Authors: Freye Chris E. , Nguyen Thuy‐Ai D. , Tappan Bryce C. 
Published: August 2021

AbstractIn order to further gain a comprehensive chemical understanding of erythritol tetranitrate (ETN), the synthesis impurities of ETN were investigated using ultrahigh performance liquid chromatography with tandem high resolution mass spectrometry (UHPLC‐MS/MS). A total of 12 impurities were identified relating to the synthesis of ETN. We have synthesized pure analytical standards of erythritol‐1,4‐dinitrate (1,4‐EDiN) and erythritol‐1,2,4‐trinitrate (1,2,4‐ETriN). These isomerically pure standards have allowed for confirmation of the identity of some of the discovered impurities. Additionally, partially nitrated with sulfate substituted erythritol was identified which is theorized to have formed from the incomplete displacement of the formed sulfate group on the alcohol position during nitration.
Discounted near‐optimal regulation of constrained nonlinear systems via generalized value iteration
Authors: Wang Ding , Zhao Mingming , Ha Mingming , Qiao Junfei 
Published: August 2021

AbstractIn this article, a generalized value iteration algorithm is developed to address the discounted near‐optimal control problem for discrete‐time systems with control constraints. The initial cost function is permitted to be an arbitrary positive semi‐definite function without being zero. First, a nonquadratic performance functional is utilized to overcome the challenge caused by saturating actuators. Then, the monotonicity and convergence of the iterative cost function sequence with the discount factor are analyzed. For facilitating the implementation of the iterative algorithm, two neural networks with Levenberg–Marquardt training algorithm are constructed to approximate the cost function and the control law. Furthermore, the initial control law is obtained by employing the fixed point iteration approach. Finally, two simulation examples are provided to validate the feasibility of the present strategy. It is emphasized that the established control laws are successfully constrained for randomly given initial state vectors.
Catalytic and Mechanistic Insights into Side‐Chain Alkenylation of Toluene with Methanol for Styrene Formation
Authors: Hattori Hideshi , Aitani Abdullah M. 
Published: August 2021

AbstractThe literature on catalytic and mechanistic aspects of the side‐chain alkenylation of toluene with methanol for the formation of styrene on solid base catalysts is reviewed. The development of catalysts and catalysis are described mostly on alkali ion exchange zeolite catalysts with fundamental chemistry related to the side‐chain alkenylation. Mechanistic studies performed from various viewpoints are described. Methods to elucidate the reaction mechanisms are discussed based on the identification of the adsorbed species of the reactants, use of plausible intermediate compounds as reactant, characterization of surface properties to examine the correlation with reaction results, poisoning of the active sites by certain molecules, and theoretical calculations of the energy profile along with the reaction coordinate. These studies are discussed with critical assessments. The review addresses several challenges that prevent the side‐chain alkenylation of toluene with methanol from industrialization which include decomposition of methanol to CO and H2, and co‐production of ethylbenzene. The paper covers mostly literature published during the period from 2000 to early 2021.
Topographically Conductive Butterfly Wing Substrates for Directed Spiral Ganglion Neuron Growth
Authors: Wei Hao , Chen Zhuoyue , Hu Yangnan , Cao Wei , Ma XiaoFeng , Zhang Chen , Gao Xia , Qian Xiaoyun , Zhao Yuanjin , Chai Renjie 
Published: August 2021

AbstractSpiral ganglion neuron (SGN) degeneration can lead to severe hearing loss, and the directional regeneration of SGNs has shown great potential for improving the efficacy of auditory therapy. Here, a novel 3D conductive microstructure with surface topologies is presented by integrating superaligned carbon‐nanotube sheets (SA‐CNTs) onto Morpho Menelaus butterfly wings for SGN culture. The parallel groove‐like topological structures of M. Menelaus wings induce the cultured cells to grow along the direction of its ridges. The excellent conductivity of SA‐CNTs significantly improves the efficiency of cellular information conduction. When integrating the SA‐CNTs with M. Menelaus wings, the SA‐CNTs are aligned in parallel with the M. Menelaus ridges, which further strengthens the consistency of the surface topography in the composite substrate. The SA‐CNTs integrated onto butterfly wings provide powerful physical signals and regulate the behavior of SGNs, including cell survival, adhesion, neurite outgrowth, and synapse formation. These features indicate the possibility of directed regeneration after auditory nerve injury.
Cost‐Efficient Photovoltaic‐Water Electrolysis over Ultrathin Nanosheets of Cobalt/Iron–Molybdenum Oxides for Potential Large‐Scale Hydrogen Production
Authors: Yi Xinli , Song Lizhu , Ouyang Shuxin , Wang Ning , Chen Huayu , Wang Jianbo , Lv Jun , Ye Jinhua 
Published: August 2021

AbstractUnassisted photovoltaic (PV) water splitting to hydrogen system is of great potential for future environmental‐friendly fuel production from renewable solar energy. However, industrialization simultaneously requires higher efficiency, sustained stability and a lower cost for the system. In this work, the ultrathin cobalt/iron–molybdenum oxides nanosheet on nickel foam (NF) is prepared for efficient HER and OER, respectively, delivering a relatively low voltage of 1.45 V at 10 mA cm−2 in two‐electrodes configuration. Water electrolysis at low voltage driven by electrocatalysts is critical for realizing energy conversion. Integrated with a commercial monocrystalline silicon cell, the H2 area specific activity of 0.47 L m−2 h−1 is achieved with a solar‐to‐hydrogen efficiency of 15.1% under solar simulator illumination (100 mW cm−2) and no performance degradation appeares over 160 h. Such a solar conversion technology demonstrates the potential for long‐term and cost‐efficient H2 production in large‐scale industrialization and provides an exploration for new‐type of energy‐conversion system.
Plexcitonic Quasi‐Bound States in the Continuum
Authors: Zheng Peng , Raj Piyush , Mizutani Takayuki , Szabo Miklos , Hanson William A. , Barman Ishan 
Published: August 2021

AbstractEnhancing light‐matter interactions is fundamental to the advancement of nanophotonics and optoelectronics. Yet, light diffraction on dielectric platforms and energy loss on plasmonic metallic systems present an undesirable trade‐off between coherent energy exchange and incoherent energy damping. Through judicious structural design, both light confinement and energy loss issues could be potentially and simultaneously addressed by creating bound states in the continuum (BICs) where light is ideally decoupled from the radiative continuum. Herein, the authors present a general framework based on the two‐coupled resonances to first conceptualize and then numerically demonstrate a type of quasi‐BICs that can be achieved through the interference between two bare resonance modes and is characterized by the considerably narrowed spectral line shape even on lossy metallic nanostructures. The ubiquity of the proposed framework further allows the paradigm to be extended for the realization of plexcitonic quasi‐BICs on the same metallic systems. Owing to the topological nature, both plasmonic and plexcitonic quasi‐BICs display strong mode robustness against parameters variation, thereby providing an attractive platform to unlock the potential of the coupled plasmon‐exciton systems for manipulation of the photophysical properties of condensed phases.
Assessing test suites of extended finite state machines against model‐ and code‐based faults
Authors: El‐Fakih K. , Alzaatreh Ayman , Türker Uraz Cengiz 
Published: August 2021

SummaryTests can be derived from extended finite state machine (EFSM) specifications considering the coverage of single‐transfer faults, all transitions using a transition tour, all‐uses, edge‐pair, and prime path with side trip. We provide novel empirical assessments of the effectiveness of these test suites. The first assessment determines for each pair of test suites if there is a difference between the pair in covering EFSM faults of six EFSM specifications. If the difference is found significant, we determine which test suite outperforms the other. The second assessment is similar to the first; yet, it is carried out against code faults of 12 Java implementations of the specifications. Besides, two assessments are provided to determine whether test suites have better coverage of certain classes of EFSM (or code) faults than others. The evaluation uses proper data transformation of mutation scores andp‐value adjustments for controlling Type I error due to multiple tests. Furthermore, we show that subsuming mutants have an impact on mutation scores of both EFSM and code faults; and accordingly, we use a score that removes them in order not to invalidate the obtained results. The assessments show that all‐uses tests were outperformed by all other tests; transition tours outperformed both edge‐pair and prime path with side trips; and single‐transfer fault tests outperformed all other test suites. Similar results are obtained over the considered EFSM and code fault domains, and there were no significant differences between the test suites coverage of different classes of EFSM and code faults.
Genetic trend of the junctional epidermolysis bullosa in the German shorthaired pointer in Italy
Authors: Frattini Stefano , Polli Michele , Cortellari Matteo , Negro Alessio , Bionda Arianna , Riva Jacopo , Rizzi Rita , Marelli Stefano , Crepaldi Paola 
Published: August 2021

AbstractBackgroundEpidermolysis bullosa (EB) is a hereditary heterogeneous group of mechanobullous disorders caused by mutations in several structural skin proteins observed in both humans and animals. In this work, we report the incidence and the genetic trend of the junctional epidermolysis bullosa (JEB), a major type of EB, in the Italian German Shorthaired Pointer (GSPs) population in a 10 years span.MethodsIn this study, we monitored the genetic trend of JEB in the Italian population of the GSPs from 2009 to 2018 in 750 animals. The studied mutation was the insertion (4818+207 ins 6.5 kb) of repetitive satellite DNA within intron 35 of the LAMA3 gene.ResultsAllele frequencies showed a reduction of the mutated (C) allele during the years, with the only exception of 2017, when 13 dogs were diagnosed as carrier for the genetic pathology. A regression logistic analysis was performed, including sex, coat colour and their interaction. Our results showed that there was a statistically significant association with coat colour.ConclusionsThe simplicity and the low cost of the analysis for the detection of this pathology suggests that a deeper identification of carrier dogs will allow better breeding strategies and management, leading to a rapid JEB eradication.
Estimation of blade loads for a variable pitch vertical axis wind turbine from particle image velocimetry
Authors: LeBlanc Bruce , Ferreira Carlos 
Published: August 2021

AbstractThis paper presents the flow fields and aerodynamic loading of a two bladed H‐type vertical axis wind turbine with active variable pitch for load and circulation control. Particle Image Velocimetry is used to capture flow fields at six azimuthal positions of the blades during operation, three upwind and three downwind. Flow phenomena such as dynamic stall and tower shadow are captured in the flow fields. The phase‐averaged velocity fields and their time and spatial derivatives are used to calculate the normal and tangential loading at each position for each pitching configuration using the Noca formulation of the flux equations. The results show the effect of load shifting from the upwind to downwind region of the actuator using pitch and the effects of dynamic stall on the blades. The results also provide an unique database for model validation.
Reproductive cycles of neotropical boid snakes evaluated by ultrasound
Authors: Garcia Viviane C. , de Almeida‐Santos Selma Maria 
Published: August 2021

AbstractSnakes have increasingly been bred as pets around the world. Few studies have addressed the reproduction of boid snakes, and no study has addressed their reproductive cycles in captivity. Thus, this paper describes the reproductive aspects of Brazilian boids in captivity. We used ultrasonography to characterize the reproductive cycle of four boid species in captivity in the Southern Hemisphere: the anaconda (Eunectes murinus), the red‐tailed boa (Boa constrictor constrictor), the Amazon tree boa (Corallus hortulanus), and the rainbow boa (Epicrates cenchria). Nonvitellogenic follicles occurred from January to December in anaconda and red‐tailed boa and for a shorter period from September to February in Amazon tree boa and from January to May in rainbow boa. Vitellogenesis occurred from late June to late March in E. murinus in year‐round (12 months), from March to March in Amazon tree boa, from late September to late March in red‐tailed boa, and from late March to late September in rainbow boa. Mating occurred from late March to late September in red‐tailed boa and rainbow boa and from late September to late March in Amazon tree boa. No mating was observed in anacondas, but a female probably underwent parthenogenesis. Births occurred in July in anaconda and in March to July in Amazon tree boa and from December to March in red‐tailed boa and rainbow boa. In males, increases in testicular size were associated with the mating season. Ultrasonography proved to be a safe and noninvasive technique to study the reproductive cycle of giant snakes in captivity.
Compositional Analysis of Protocol Equivalence in the Applied $$\pi $$-Calculus Using Quasi-open Bisimilarity
Authors: Horne Ross , Mauw Sjouke , Yurkov Semen 
Published: August 2021

AbstractThis paper shows that quasi-open bisimilarity is the coarsest bisimilarity congruence for the applied $$\pi $$
π
-calculus. Furthermore, we show that this equivalence is suited to security and privacy problems expressed as an equivalence problem in the following senses: (1) being a bisimilarity is a safe choice since it does not miss attacks based on rich strategies; (2) being a congruence it enables a compositional approach to proving certain equivalence problems such as unlinkability; and (3) being the coarsest such bisimilarity congruence it can establish proofs of some privacy properties where finer equivalences fail to do so.
Die Familienthematik in der (TV-)Serie: Historische Entwicklung, Bedeutung und Ausblick
Authors: Kelsch Jakob 
Published: August 2021

ZusammenfassungDas zweite Kapitel umfasst einen ausführlichen Überblick über die Entwicklung der Familiendarstellung in der TV-Serie von ihren Ursprüngen bis heute. Diese Darstellung folgt einer Wellen- bzw. Mäanderbewegung: In den 1950er und 1960er Jahren bildete sich der Mythos der patriarchalen Kernfamilie als Ideal des familiären Zusammenlebens. In den folgenden Jahrzehnten folgten Phasen der Dekonstruktion und der Darstellung problematischer Familienverhältnisse auf Phasen der Rückkehr zum ursprünglichen Ideal der Kernfamilie. Auch wenn Elemente des gesellschaftlichen Wandels in die Weltbilder integriert werden, bleibt dabei der Mythos der idealen Kernfamilie als überzeitliche Konstante bestehen. Am Ende des historischen Überblicks folgt eine detailliertere Auslotung der Potentiale und der Entwicklung der Video-on-Demand-Anbieter.
Concluding Remarks
Authors: Müller Birgit Charlotte 
Published: August 2021

ZusammenfassungDespite being of fundamental economic and scientific importance, international financial markets have remained considerably underresearched until today. This thesis presents three essays on empirical asset pricing in international equity markets. In the first essay, the role of firm-specific characteristics is analyzed for the momentum effect to exist. The second essay investigates the validity, persistence, and robustness of the newly discovered capital share growth factor across international markets as proposed by Lettau et al. (2019) for the U.S. market.
Discovery of higher-order quantum electrodynamics effect for the vacuum pair production
Authors: Zha W. , Tang Z. 
Published: August 2021

Abstract
The higher-order quantum electrodynamics (QED) effect for vacuum pair production has been searched without success since 1954. In this paper, we show that the combined world-wide data of lepton pair vacuum production is about 20% smaller than the latest lowest order QED calculation with a 5.2 sigma-level of significance and is consistent with the corresponding higher-order QED result. We claim the discovery of higher-order effect for the QED pair production, which settles the dust of previous debates for several decades. The verification of higher-order QED effect is a fundamental scientific problem, which is an important milestone towards the nonperturbative and nonlinear regime of QED vacuum.
Muon (g − 2) in the B-LSSM
Authors: Yang Jin-Lei , Zhang Hai-Bin , Liu Chang-Xin , Dong Xing-Xing , Feng Tai-Fu 
Published: August 2021

Abstract
The difference between the updated experimental result on the muon anomalous magnetic dipole moment and the corresponding theoretical prediction of the standard model on that is about 4.2 standard deviations. In this work, we calculate the muon anomalous MDM at the two-loop level in the supersymmetric B − L extension of the standard model. Considering the experimental constraints on the lightest Higgs boson mass, Higgs boson decay modes h → γγ, WW, ZZ, $$ b\overline{b} $$
b

b
¯

, $$ \tau \overline{\tau} $$
τ

τ
¯

, B rare decay $$ \overline{B} $$

B
¯

→ Xsγ, and the transition magnetic moments of Majorana neutrinos, we analyze the theoretical predictions of the muon anomalous magnetic dipole moment in the B − L supersymmetric model. The numerical analyses indicate that the tension between the experimental measurement and the standard model prediction is remedied in the B − L supersymmetric model.
Exploring the landscape of CHL strings on Td
Authors: Font Anamaría , Fraiman Bernardo , Graña Mariana , Núñez Carmen A. , De Freitas Héctor Parra 
Published: August 2021

Abstract
Compactifications of the heterotic string on special Td/ℤ2 orbifolds realize a landscape of string models with 16 supercharges and a gauge group on the left-moving sector of reduced rank d + 8. The momenta of untwisted and twisted states span a lattice known as the Mikhailov lattice II(d), which is not self-dual for d > 1. By using computer algorithms which exploit the properties of lattice embeddings, we perform a systematic exploration of the moduli space for d ≤ 2, and give a list of maximally enhanced points where the U(1)d+8 enhances to a rank d + 8 non-Abelian gauge group. For d = 1, these groups are simply-laced and simply-connected, and in fact can be obtained from the Dynkin diagram of E10. For d = 2 there are also symplectic and doubly-connected groups. For the latter we find the precise form of their fundamental groups from embeddings of lattices into the dual of II(2). Our results easily generalize to d > 2.