bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatiotemporal change and attribution of potential evapotranspiration over China from 1901 to 2100
Authors: Peng Shouzhang , DING Yongxia 
Published: February 2021

Abstract
Global warming has accelerated surface water loss around the world. This study investigates in detail the change and attribution of potential evapotranspiration (PET) across China from 1901 to 2100 by the Hargreaves model, based on a 1-km temperature dataset downscaled from the low-spatial-resolution datasets using a Delta downscaling framework. Results showed that (1) relative to 1961–1990, PET increased by 0.62% in the historic period (1901–2017) and 6.43–12.89% for the future period (2018–2100), suggesting considerable future drying for China. Moreover, these increments had strong spatial variations and the largest increases were detected in high-elevation regions; (2) PET over entire China demonstrated a nonsignificant upward trend during the historic period and significant upward trends for the future period. For each period and GCM, significant upward PET trends occupied a much larger percent area than significant downward trends; (3) PET variations during the historic period were most sensitive to mean temperature (TMP), while in the future period it was more sensitive to maximum temperature (TMX), suggesting a change in the primary sensitivity factor due to global warming; (4) minimum temperature (TMN) made the largest contribution (45%) to PET variations during the historic period, while TMX had the largest contribution (36–40%) in the future period. Therefore, the primary contributing factor might transform from TMN to TMX under climate change; and (5) PET variations exhibited strong spatial heterogeneity, detected on fine geographic scales, due to the use of downscaled dataset. Overall, the results present a deep insight for planning coping strategies of global warming in China.
Multiplicative Gains, Non-ergodic Utility, and the Just One More Paradox (with Supplemental Information)
Authors: Myers John K. 
Published: February 2021

Abstract
Interest in multiplicative vs. additive returns on bets has been revived by Peters, who proposes ergodicity and added noise are useful in understanding utility preferences. Peters requires a Monte Carlo simulation to demonstrate empirically a supposed paradox that arithmetic expectation is inappropriate for multiplicative gain distribution forecasting. Here I formalize the r operator notation, which significantly simplifies multiplicative problems, as an extension of the arithmetic group's Δ/d discrete and continuous operators into the multiplicative semigroup. I show how the annihilating (absorbing) element of the multiplicative semigroup at 0, not +/-∞, may be used to conveniently represent nonlinear sequence occurrences, such as running out of money, without the need for special computer rules outside the mathematics. I use this to solve Peters' expected-value paradox elegantly, without ergodicities nor noise. But Peters misses the real paradox, called “Just One More”: the outcome of an advantageous additive gamble is identical to the outcome of a similar disadvantageous multiplicative gamble, after one trial; hence, by induction, an agent will keep playing. I propose games “Hero or Heroin” and “American Roulette” to highlight this paradox. This may help in explaining addiction. The Supplement contains further visualizations and arguments against the need and applicability of ergodics for utility. The results contribute to the understanding of repeated multiplicative gambles with annihilating states, and their utility.
Current Status on Training and Education on Public and Healthcare Workers towards Tuberculosis Elimination: Case in South Korea
Authors: Kang Taeuk , Park Seungkyu , Ryoo Sungweon 
Published: February 2021

Abstract
Tuberculosis, despite global effort to eliminate tuberculosis, still remains as a high burden to global public health. For tuberculosis elimination to be achieved, trainings and educations play pivotal role, tuberculosis control and prevention in particular. Internationally, several organizations are in charge of tuberculosis training and education program design, especially in its preparation and dissemination. In case of Korea, TB prevalence remains high, 59.0 per 100,000 in 2019. To overcome TB, institutes from both governmental and public sectors are organizing and providing tuberculosis-related training and education programs however, only few investigations on tuberculosis training in Korea was carried out, indicating difficulty lies in understanding and analyzing current TB training and education landscape. Hence, in this study, we have reviewed each institute and their roles in terms TB training and educational aspects as well as current tuberculosis status and strategies employed in Korea. Also, there are limitation lies in tuberculosis training and education thus, the call for global cooperation is necessary to response regional consideration against tuberculosis.
Deep learning analysis of drug-induced ECG changes to inform arrhythmia risk and improve diagnosis of congenital long QT syndrome
Authors: Prifti Edi , Fall Ahmad , Davogustto Giovanni , Pulini Alfredo , Denjoy Isabelle , Funck-Brentano Christian , Khan Yasmin , Durand-Salmon Alexandre , Wells Quinn , Leenhardt Antoine , Zucker Jean-Daniel , Roden Dan , Extramiana Fabrice , SALEM Joe-Elie 
Published: February 2021

Abstract
Congenital or drug-induced long-QT syndromes can cause Torsade-de-Pointes (TdP), a life-threatening ventricular arrhythmia. The current strategy to identify individuals at high risk of TdP consists on measuring the QT duration on the electrocardiogram (ECG), shown to provide limited information. We propose an original method, including training deep neural networks to recognize ECG alterations induced by QT-prolonging drugs, as a comprehensive evaluation of TdP risk. These models accurately detected patients taking QT prolonging drugs during ECGs, while discriminating for the presence and type of congenital long-QT. Moreover, they enhanced prediction of drug-induced TdP events in addition to QT measurement. Analyses of these models revealed footprints of the torsadogenic risk and clinically relevant patient stratification.
Global Stability and Sensitivity Assessment of COVID-19 with Timely and Delayed Diagnosis in Ghana
Authors: Moore Stephen E. , Bamen Hetsron L. Nyandjo , Asamoah Joshua Kiddy K. , Menoukeu-Pamen Olivier , Jin Zhen 
Published: February 2021

Abstract
In this paper, we present the dynamical effects of timely and delayed diagnosis on the spread of COVID-19 in Ghana, using reported data from March 12 to June 19, 2020. The estimated basic reproduction number, R_0, for the proposed model is 1.04. One of the main focus of this study is stability results and senesitity assessment of the parameters. We show both theoretically and numerically that, the disease can be eliminated when the basic reproduction number is less or equal to a unity. Furthermore, we show that the disease persist whenever R_0>1 or whenever there is a delay in the diagnoses of infected individuals in the community. To assess the most influential parameters in the basic reproduction number, we carried out global sensitivity analysis. The scatter plots and the partial rank correlation coefficient reveal that, the most positive sensitive parameter is the recruitment rate, followed by the relative transmissibility of exposed individuals; and that the most negative sensitive parameters are the proportion of the infectious with timely diagnosis, and the transition rate of self-quarantined individuals to the susceptible population. For public health benefit, our analysis suggests that, a reduction in the inflow of new individuals into the country or a reduction in the inter community inflow of individuals will reduce the basic reproduction number and thereby reduce the number of secondary infections (multiple peaks of the infection).
&nbsp;A Simplified Model of Low Reynolds Number, immiscible, Gas-Liquid Flow and Heat Transfer in Porous Media (Numerical Solution with Experimental Validation)
Authors: Abdelaziz Gamal B. , Abdelgaleel M. , Omara Z.M. , Abdullah A. S. , El-Said Emad M.S. , Sharshir Swellam W. , Elsaid Ashraf Mimi 
Published: February 2021

Abstract
This study investigates the thermal-hydraulic characteristics of immiscible two-phase flow (gas/liquid) and heat transfer through porous media. This research topic is interested among others in trickle bed reactors, the reservoirs production of oil, and the science of the earth. Characteristics of two-phase concurrent flow with heat transfer through a vertical, cylindrical, and homogeneous porous medium were investigated both numerically and experimentally. A generalized Darcy model for each phase is applied to derive the momentum equations of a two-phase mixture by appending some constitutive relations. Gravity force is considered through investigation. To promote the system energy equation, the energy equation of solid matrix for each phase are deemed. The test section is exposed to a constant wall temperature after filled with spherical beads. Numerical solution of the model is achieved by the finite volume method. The numerical procedure is generalized such that it can be reduced and applied to single phase flow model. The numerical results are acquired according to, air/water downward flow, spherical beads, ratio of particle diameter to pipe radius D=0.412, porosity φ=0.396, 0.01≤Re≤500, water to air volume ratio 0≤W/A≤∞, and saturation ratio 0≤S1≤1. To validate this model an experimental test rig is designed and constructed, and the corresponding numerical results are compared with its results. Also, the numerical results were compared with other available numerical results. The comparisons show good agreement and validate the numerical model. One of the important results reveals that the heat transfer is influenced by two main parameters; saturation ratios of the two fluids; S1 and S2, and the mixture Reynolds number Re. The thermal entry length is directly dependent on Re, S1, and the thermofluid properties of the fluids. A modified empirical correlation for the entrance length; Xe =0.1 Re.Pr.Rm is predicted, where Rm =Rm(S1, S2, ρ1, ρ2, c1, c2). The predicted correlation is verified by comparing with the supposed correlation of Poulikakos and Ranken (1987) and El-Kady (1997) for a single-phase flow; Xe/Pr=0.1 Re.
Prace konserwatorskie przy kamiennej rzeźbie Matki Boskiej autorstwa Andrzeja Pruszyńskiego z elewacji kościoła pw. Matki Bożej Pocieszenia w Żyrardowie – wybrane zagadnienia historyczne i technologiczne
Authors: Owczarek Piotr 
Published: February 2021

SUMMARY
The stone sculpture of the Virgin Mary from the facade of the church Our Lady of Consolation in Żyrardów is one of the numerous sculptural implementations of Andrzej Pruszyński workshop. In 2018 the monument was under conservation and restoration works. Preliminary macroscopic examination of the monument showed that under the numerous secondary layers of paint on the stone sculpture there is a dark green, multi-deck colour layer that could imitate a statue had made in bronze casting technique. As a result samples were taken and subjected to laboratory analysis. The research carried out allowed us to conclude that the described layer is kind of a secondary nature and is a testimony to the restoration of the monument probably after the end of World War I. It was decided not to remove the patina and to fill in the gaps in the course of the ongoing restoration and conservation works. This layer had historical and documentary value and was a testimony to the popular in the 19th century and probably known at the beginning of the 20th century practice of patinating sculptures made in less noble and less durable material than bronze. Moreover, in the course of conservation works later layers of paint and cement repairs were removed. Then the structure of weakened limestone rock was strengthened and numerous small losses of stone were filled in. As a witness the defect on the left knee of the figure was left without filling in. It is a trace of the bullet that was probably created during World War I. Moreover, the missing figure’s right hand was reconstructed. A reconstruction of the gilded halo was also made. The design of the conservation work programme is always a very complex process as it requires the simultaneous consideration of many factors. The aesthetic and historical interpretation of the work is important, the understanding of the author’s concept and the essence of the destructive processes. In the case of the described sculpture from Żyrardów it was also necessary to take into account the technical possibilities, take into account the expectations of the owner and users, or customers in general, as well as the conservation community. Preservation and restoration solutions adopted in the work programme, including hand reconstruction and unveiling of the following items and the restoration of a painting layer imitating a green patina, restored historical artistic values to the monument. The aesthetic effect achieved this way brings a new quality to work that can be the object of criticism but by restoring the sculpture’s lost aesthetic values it is possible to continue to function as an object of religious worship.
Ensuring the Quality of Higher Education Under Current Conditions
Authors: Kostyshyn Andriy 
Published: February 2021

Abstract. In the present conditions, especially during a pandemic, higher education requires academic staff to master and implement innovative methods of teaching and learning based on information programs, knowledge transfer systems. The tasks of interactive educational forms are as follows: awakening students’ interest; motivating students to solve the problem under study; effective mastering educational material; independent searching for the methods and options how to solve the educational task; interactions between students; teamwork skills; tolerance for any point of view; forming students’ own opinion, life and professional skills; reaching the level of student’s conscious competence. After analyzing our research, we can state that interactive learning creates an environment of educational communication, which is characterized by openness, equal-footing interaction of participants, accumulation of mutual knowledge, that provides high motivation, strength of knowledge, creativity, sociability, active life position, preservation of individuality, freedom of expression, mutual respect.
This paper examined the current problems of innovative technologies and teaching methods in modern higher education, as the tendency to humanization and humanitarization of the content of medical education has intensified, new academic disciplines have been introduced and, consequently, the need for academic staff, who could provide an innovative approach to implementing these trends during the educational process, has been increased. It is significant that today teachers are able to create and implement their own innovative methods. In addition, the paper focused on the safety of the educational environment of higher education. Information security is especially important, as nowadays the information media have an extremely big impact on the student environment.
Youth Professional Development
Authors: Skrobach Nadiia , Shapoval Oksana , Vyshyvanyuk Vira , Petryna Vitalii 
Published: February 2021

Professional adaptation is a process of engaging young people in professional activity that is influenced by the right career choice, the level of professional orientation, as well as the type of professional training. Professional adaptation is considered as a special type of social process aimed at engaging the group of people in working life, as they were artificially disconnected from this life during their study.
The formation of professional orientation is influenced by several objective and subjective factors. The objective factors include specific socio-economic conditions that will determine the role of an individual in the system of working relations, as well as the nature of work, its stimulation, working conditions and working environment. Nowadays these factors are significantly influenced by economic crisis, unemployment, lack of social protection, as well as the expansion of international contacts, the appearance of new forms of employment, the introduction of information technologies, etc. The subjective factors include personality traits, the interest in performing the activity, the satisfaction from performing the activity, motives and goals inducing this activity.
During the preadaptation period, an individual becomes acquainted with new duties and responsibilities that team members and the administration are expected of them to carry out; the individual’s training level and their ability to carry out professional duties are assessed as well. This period can last from a few months to a year. During the next period of inadaptation, an individual assumes a social role of a worker, accepts the goals and tasks of the organization and starts to carry out the planned tasks. In the period of post-adaptation, in case of positive adaptation, the employee’s activity is aimed at creative application of the experience and knowledge acquired.
Thus, professional success can serve as the objective criterion for professional adaptation, while job satisfaction can be considered as the subjective one. To assess the results of professional adaptation, the adaptation levels, namely high, moderate and low can be used.
Development of a Novel Intervention (Mindful Steps) to Promote Long-Term Walking Behavior in Chronic Cardiopulmonary Disease: Protocol for a Randomized Controlled Trial
Authors: Litrownik Daniel , Gilliam Elizabeth A , Wayne Peter M , Richardson Caroline R , Kadri Reema , Rist Pamela M , Moy Marilyn L , Yeh Gloria Y 
Published: February 2021

Background
Despite current rehabilitation programs, long-term engagement in physical activity remains a significant challenge for patients with chronic obstructive pulmonary disease (COPD) and heart failure (HF). Novel strategies to promote physical activity in these populations are greatly needed. Emerging literature on the benefits of both mind–body interventions and web-based interventions provide the rationale for the development of the Mindful Steps intervention for increasing walking behavior.

Objective
This study aims to develop a novel multimodal mind–body exercise intervention through adaptation of an existing web-based physical activity intervention and incorporation of mind–body exercise, and to pilot test the delivery of the new intervention, Mindful Steps, in a randomized controlled feasibility trial in older adults with COPD and/or HF.

Methods
In phase 1, guided by a theoretical conceptual model and review of the literature on facilitators and barriers of physical activity in COPD and HF, we convened an expert panel of researchers, mind–body practitioners, and clinicians to inform development of the novel, multimodal intervention. In phase 2, we are conducting a pilot randomized controlled feasibility trial of the Mindful Steps intervention that includes in-person mind–body exercise classes, an educational website, online mind–body videos, and a pedometer with step-count feedback and goals to increase walking behavior in patients with COPD and/or HF. Outcomes include feasibility measures as well as patient-centered measures.

Results
The study is currently ongoing. Phase 1 intervention development was completed in March 2019, and phase 2 data collection began in April 2019.

Conclusions
Through the integration of components from a web-based physical activity intervention and mind–body exercise, we created a novel, multimodal program to impact long-term physical activity engagement for individuals with COPD and HF. This developmental work and pilot study will provide valuable information needed to design a future clinical trial assessing efficacy of this multimodal approach.

Trial Registration
ClinicalTrials.gov NCT03003780; https://clinicaltrials.gov/ct2/show/NCT03003780

International Registered Report Identifier (IRRID)
DERR1-10.2196/27826
Propiedades mecánicas de morteros con arenas del centro de México
Authors: Muciño Velez Alberto , López Calvo Herwing Zeth , Guillén Guillén Cesar Armando , Carbajal García Cristhian David 
Published: February 2021

Se estudió el efecto de los agregados finos en las mezclas de mortero empleando diferentes cementos portland tipo II 30R RS, con el objetivo de lograr resistencias a la compresión óptimas según la normatividad. Se desarrollaron 15 diseños de mezclas relacionando cinco marcas de cemento y tres tipos de arena, con las cuales se elaboraron 75 probetas cúbicas para determinar su resistencia a la compresión. Los resultados demuestran que existen resistencias variables al emplear distintos tipos de arena y cemento. El análisis granulométrico determinó que solo uno de los tipos de tres tipos de arena tiene tamaños de partícula apropiados y la evaluación de pastas con cemento de cinco marcas del tipo II, presentaron diferencias en propiedades mecánicas. Se discute qué marcas de cemento no cumplen con la resistencia especificada, y que la relación arena-cemento debe considerar el origen del agregado fino y la relación con la marca empleada. Se pueden lograr reducciones de cemento al conocer el rendimiento de la arena en la mezcla. La arena sí influye en la resistencia de los morteros y cada agregado presentó un desempeño diferenciado por cada marca de cemento. Se concluye que los bancos de materiales contienen composiciones diferentes influenciando las características y propiedades de las arenas y que entre diferentes marcas de cemento portland tipo II 30R RS se obtuvieron resistencias a la compresión diferentes, aun cuando su especificación los coloca en el mismo tipo.
Extent of Pharmacotherapy in Covid-19: An Observational Study in a Dedicated Hospital in Bangladesh
Authors: Perveen Rawshan Ara , Nasir Morshed , Rahman AFM Mohibur , Zahan Tahmina , Farha Nadia , Chaudhury ASM Salauddin 
Published: February 2021

Objective: With the rapid increase in the rate of infection, repurposing use of many drugs like antivirals, antibiotics, LMWH, steroid, oxygen therapy were considered as an option to find promising anti-COVID therapeutics. In this study, we aim to observe the extent and variety of drugs used in different clinical categories of COVID-19 patients admitted to hospital in Bangladesh. To observe the requirement of oxygen therapy according to severity was also a prime objective to reveal the overall trend, frequency, and pattern of pharmacotherapy in a COVID-dedicated hospital.
Materials and method: A total of 1348 patients were admitted, of whom 473 were included in this single-center retrospective study. The critical group consists of 99 ICU patients, the severe group has 38, moderate was 82 and mild group 254 cases, admitted in the general ward. Hospital records of each patient were screened and information about drug and supportive therapy were collected manually by the researchers in the data collection sheet. Data express in MS excel spreadsheet and result expressed in percentage.
Results: Critical group received remdesivir (85.86%), favipiravir (27.28%), meropenem (92.93%), moxifloxacin (87.88%) dexamethasone (41.48%), Low Molecular Weight Heparin (98.99%). They also received supportive O2 therapy like High Flow Nasal Cannula (67.68%), Non-Invasive Ventilation (26.67%), and mechanical ventilator (6.06%). A severe group of patients receives the same group of drugs 97.27%, 5.26%, 60.53%, 47.37%, methylprednisolone (55.26%), and 100% LMWH. A moderate group of the patient received favipiravir (97.56%), cephalosporin (64.67%), LMWH (89.02%) and low flow O2 (97.36%) in a higher percentage. All patients of the mild group received doxycycline, ivermectin. Total 33 patients transfuse convalescent plasma.
Conclusion: Antiviral, broad-spectrum antibiotics, anti-protozoal, LMWH, corticosteroid, and oxygen therapy are the available treatment option against different clinical categories of admitted COVID-19 patients.
Keywords: COVID-19, antiviral, antibiotic, steroid, O2 therapy