bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unusual Cases of Pure Malignant Germ Cell Tumors of the Ovary: A Case Series on 10 Years Experience at a Tertiary Care Center
Authors: Goyal Lajya Devi , Kaur Balpreet , Goyal Gitanjali , Rajora Parveen 
Published: November 2021

Background: Malignant ovarian germ cell tumors (MOGCTs) are rare female cancers, constituting up to 10% of ovarian cancers. Dysgerminoma is the most common histological variant. Surgical removal of the tumor with optimal debulking is the treatment of choice. Multidrug chemotherapy following surgery offers high remission rates. Considering the prevalence of these tumors in adolescent and young females, fertility-sparing treatment is of paramount importance.
Methods: The data of all patients with ovarian malignancy admitted at a tertiary-care-teaching hospital from September 2009-March 2019 were analyzed. Ten patients of MOGCTs were treated in this period. The clinical features, radiological and biochemical findings, and management and treatment outcome were evaluated.
Results: The median age of patients was 23 years. Histological subtypes included immature teratoma (n=3), endodermal sinus tumor (n=4), and dysgerminoma (n=3). Tumor markers namely AFP, βHCG, and LDH increased in all except the patients with immature teratoma. Two patients with dysgerminoma were in the second trimester of pregnancy. All patients except one underwent surgery followed by BEP chemotherapy. Two patients had developed metastasis within six months of treatment and died. In seven patients, no evidence of disease was reported till date.
Conclusion: Management of antenatal patients with dysgerminoma by surgery followed by BEP chemotherapy has favorable prognosis. Fertility-sparing surgery with adjuvant chemotherapy offers great advantage in young girls. However, risk stratification based on prognostic factors should be implemented in order to individualize the treatment for achieving higher survival rates. The option for oocyte-cryopreser-vation prior to surgery must be discussed with patients desiring future fertlity.
PERCEPÇÃO DA EQUIPE DE ENFERMAGEM ACERCA DA AVALIAÇÃO DA DOR EM RECÉM-NASCIDOS PREMATUROS
Authors: Santos Carvalho Silas , De Almeida Soares Janaína , Azevedo Pinheiro Jonathas , Dos Santos Queiroz Melânia 
Published: November 2021

Objetivo: Compreender as ações do enfermeiro na avaliação e no manejo da dor nos recém-nascidos prematuros internados em uma unidade de terapia intensiva neonatal. Método: Estudo descritivo de abordagem qualitativa, desenvolvido com sete enfermeiras atuantes em uma maternidade. Os dados foram obtidos por meio de entrevista semiestruturada e as informações analisadas pelo método de análise de conteúdo temática. O projeto foi aprovado pelo Comitê de Ética em Pesquisa. Resultados: A partir da análise emergiram-se duas categorias temáticas: “Como o enfermeiro avalia a dor no recém-nascido prematuro” e “Ações do enfermeiro diante da dor no recém-nascido prematuro”. As enfermeiras afirmaram terem percepção de situações dolorosas, porém, nota-se que sua identificação ocorria de forma fragmentada e superficial. As técnicas empregadas no estudo evidenciaram a necessidade de estabelecer uma sistemática na assistência. Conclusão: Na equipe de enfermagem ainda existe uma grande distância entre o conhecimento teórico, o uso de escalas e a conduta prática quanto à avaliação e manejo da dor de recém-nascidos prematuros.Descritores: Dor; Recém-nascido prematuro; Enfermeiros; Unidade de terapia intensiva neonatal.
Praktik Pembiayaan Mudharabah dan Musyarakah terhadap Profitabilitas Bank Umum Syariah di Indonesia
Authors: Aulia Fena Ulfa , Nabila AJ Elda Ayu 
Published: November 2021

Penelitian ini bertujuan untuk mengetahui dampak pembiayaan mudharabah dan pembiayaan musyarakah terhadap profitabilitas bank umum syariah di Indonesia (Periode 2017-2019). Dalam penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian asosiatif. Popolasi yang digunakan adalah seluruh Bank Umum Syariah yang terdaftar di Indonesia. Teknik pengambilan sampel yaitu dengan menggunakan teknik Simple Random Sample. Teknik analisis data menggunakan uji asumsi klasik (uji normalitas, uji autokorelasi, uji heteroskedastisitas, uji multikolinearitas), uji analisis persamaan regresi linear berganda, dan uji statistik (uji t, uji F dan uji koefisien determinasi). Hasil penelitian menunjukkan bahwa pembiayaan mudharabah dan pembiayaan musyarakah secara simultan berpengaruh signifikan dan positif terhadap profitabilitas (ROA). Hasil pengujian secara parsial menunjukkan bahwa pembiayaan mudharabah berpengaruh signifikan dan positif terhadap profitabilitas (ROA), sedangkan pembiayaan musyarakah berpengaruh signifikan dan negatif terhadap profitabilitas (ROA)
Immunomodulator Effect of Lemongrass Extract (Cymbopogon nardus L.) to Increase Immune Cells as a Precaution Against SARS-CoV-2
Authors: Setiyowati Putri Ayu Ika , Solekha Rofiatun , Negara Sri Bintang Sahara Mahaputra Kusuma , Rosalina Reny 
Published: November 2021

Introduction: In humans, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) can damage some tissue when the immune systems was decrease. Natural product from the plant often used to improve immune response against microorganism including virus. This study aimed to determine the potential antioxidant of lemongrass extract (C . nardus) with various dosage that can provide immunomodulatory effects and find an optimal dosage to be used. Methods: The method used observasional analytic, using animal model of 30 male mice strain BALB/C, weight 25-30 gram, divided into 5 groups; the positive control group was given 0.05 mL of 0.05% CMC within 14 days, negative control group was given IMBOOST® tablet 200 mg/kg body weight (bw) within 14 days, treatment groups were given C. nardus extract with various doses 50 mg/kg bw, 150 mg/kg bw, and 300 mg/kg bw. In day 21 all group were injected with 0,2 ml of pathogen bacterial (S. aureus). Blood samples were taken three times: 7th day, 14th day, and 21th day. Results: The results showed that lemongrass extract (C. nardus) was able to influence the leukocyte and lymphocytes count with significant different (p<0.05). The optimal dose is 150 mg/kg body weight. Conclusion: The antioxidant compounds that contain in the C. nardus extract have an ability to increasing the immune system in the dose 150 mg/kg bw , but in the dose 300 mg/kg bw became toxic that can make a skin injury or death in animal test.
Pemberdayaan Dikalangan Calon Pekerja Migran Dalam Rangka Pencegahan Penyakit Menular di Desa Benculuk, Kecamatan Celuring, Kabupaten Banyuwangi Jawa Timur
Authors: Koesbardiati Toetik , Kinasih Sri Endah , Murti Delta Bayu , Ida Rachmah , Wahyudi Irfan 
Published: November 2021

Rendahnya Pekerja Migran Indonesia (PMI) sebenarnya berkorelasi lurus dengan rendahnya tingkat pendidikan formal mereka. Rata-rata pendidikan formal sebanyak 68% lulusan SD dan SMP. Pengetahuan PMI terkait dengan penularan penyakit yang disebabkan adanya pola-pola interaksi sangatlah rendah. Penyakit menular pada PMI terkait dengan pola-pola interkasi banyak dilakukan di negara tujuan. Hal ini tentunya berdampak pada penyebaran penyakit menular pada PMI purna penempatan yang semakin meningkat bahkan menyebarluas bukan hanya di daerah pengiriman saja tetapi ke wilayah-wilayah yang bukan pengiriman PMI.WHO dari Komisi Migrasi dan Kesehatan menyampaikan adanya kerentanan para migran terkait dengan hak, perawatan kesehatan sebagai hak asasi manusia. Komisi ini memberikan rekomendasi menuju Global Health dengan misi migrasi sehat. Untuk merespon situasi ini maka studi ini membahas tentang pemberdayaan dikalangan calon pekerja migran dalam rangka pencegahan penyakit menular desa Benculuk, kecamatan Celuring, kabupaten Banyuwangi Jawa Timur ini diharapkan memberikan kontribusi untuk calon PMI terkait dengan pola-pola interaksi dan berperilaku sesuai standard kesehatan dengan sesama migran, majikan maupun warga negara tujuan. Apabila ketika dalam pola-pola interaksi dan berperilaku tidak sesuai standard kesehatan maka akan berdampak penularan penyakit. Pemberdayaan ini dilakukan di Serikat Buruh Migran Indonesia (SBMI) Desa Benculuk Kecamatan Cluring Banyuwangi Provinsi Jawa Timur. Penentuan lokasi penelitian ditentukan secara purposive di kabupaten Banyuwangi merupakan salah satu kabupaten dari tujuh kabupaten di Jawa Timur pengirim pekerja migran ke luar negeri. Pengumpulan data meliputi observation dan indepth interview. Informan yang dipilih adalah individu-individu yang memiliki pengetahuan dan pengalaman tentang permasalahan yang diteliti. Terakhir adalah analisa data yaitu data yang terkumpul kemudian diklasifikasikan dan diindentifikasikan berdasarkan tema kemudian dianalisa.Hasil studi ini menunjukkan bahwa calon PMI belum memiliki pengetahuan tentang penyakit menular yang disebabkan oleh interaksi yang tidak tepat. Interkasi yang tepat akan mencegah terjadinya penularan penyakit. Apalagi informasi penularan penyakit tidak disampaikan pada pelaksanaan Pembekalan Akhir Pemberangkatan (PAP) dan tidak didukung dengan menggunakan media pengajaran seperti video, simulasi dan hanya menggunakan metode ceramah. Demikian materi yang disampaikan tidak sesuai dengan modul pegangan instruktur. Dengan adanya pemberdayaan dikalangan calon PMI terkait dengan bahaya penyakit menular perlu adanya kiat-kiat untuk menghindarinya dengan membatasi interaksi di negara tujuan.
A Multi-Mode Reasoning For Predicting Tobacco Baking Quality
Authors: Wu QingE , Zong Tao , Chen Hu , Zhou Lintao , Lu Yingbo , Li Penglei , Li Yong 
Published: November 2021

Abstract
In order to reduce the number of defective products caused by the unreasonable baking time during the tobacco production process, this paper proposes a method for establishing a multi-model reasoning tobacco baking quality prediction model. Conduct data mining and analysis on the data of various indicators of the original tobacco, and screen out the data that have an impact on the quality of tobacco baking. In order to reduce the complexity of the model and eliminate the influence between different dimensions, the data are carried out and standardized processing. Next, the normalized data is explored for the multi-input and multi-output mapping relationship. Finally, a mapping matrix is given for the multi-input and multi-output mapping relationship so as to establish a tobacco baking quality prediction model. The test results show that the predicted value of this model is basically the actual value, and the prediction accuracy rate is more than 90%. It has a high prediction accuracy rate. The cured tobacco leaves are basically the same as the actual cured yellow expected value. This model provides a practical guide method for tobacco baking, which has certain practical value in actual tobacco baking.
16S Metagenomics of Nitrifying Bacteria and Archaea Inhabiting Maize Rhizosphere and the Influencing Environmental Factors
Authors: Ayiti Oluwatobi Esther , Ayangbenro Ayansina Segun , Babalola Olubukola Oluranti 
Published: November 2021

Abstract
The maize rhizosphere soil is unique with diverse microorganisms. Nitrifying bacteria and archaea are ubiquitous and can transform ammonia locked up in soil or manure into nitrate; a more soluble form of nitrogen. However, nitrifying bacteria and archaea inhabiting maize rhizosphere are yet to be identified. We elucidate the diversity and abundance of nitrifying bacteria and archaea associated with maize rhizosphere across different growth stages using 16S metagenomics sequencing. Also, the influence of environmental factors on the nitrifying communities was evaluated. The maize rhizosphere soil was collected from North-West University, Molelwane, South Africa. DNA was extracted using Nucleospin Soil DNA extraction kit and the V3-V4 hypervariable region was sequenced on Illumina Miseq platform. MG-RAST was used to analyze the raw sequences. The environmental factors were measured using standard procedure. The result revealed 9 genera of nitrifying bacteria; Nitrospira, Nitrosospira, Nitrobacter, Nitrosovibrio, Nitrosomonas, Nitrosococcus, Nitrococcus, unclassified (derived from Nitrosomonadales), unclassified (derived from Nitrosomonadaceae) and 1 archaeon Candidatus Nitrososphaera. The Nitrospirae phyla group which had the most nitrifying bacteria was more abundant at the tasselling stage (67.94%). Alpha diversity showed no significant difference. However, the Beta diversity showed significant difference (P=0.01, R=0.58) across the growth stages. The growth stages had no significant effect on the diversity of nitrifying bacteria and archaea, but the tasselling stage had the most abundant. A correlation was observed among some of the environmental factors. The research outcome can be put into consideration while carrying out a biotechnological process that involves nitrifying bacteria and archaea.
Increased Expression Regulator of G-protein Signaling 1 Predicts Unfavorable Prognosis of Gastric Cancer
Authors: Lin Hai , Zhu Feng , Wang Jun , Liu Yubiao , Fu Weihua 
Published: November 2021

Abstract
Background: Regulator of G-protein signaling 1 (RGS1) expression has been reported to be a prognostic marker for specific cancers, but its function in gastric cancer (GC) remains to be elucidated. Methods: RNA-sequencing data and clinicopathologic characteristics of 434 GC patients were collected from The Cancer Genome Atlas (TCGA) database. the expression level of RGS1 in GC tissues are significantly higher than pan-cancer tissues. The high expression of RGS1 is associated with worse progression of GC. The diagnostic value of RGS1 was evaluated by calculating receiver operating characteristic curve (ROC). Cox proportional hazards regression modeling and Kaplan-Meier curves were used to explore clinicopathologic characteristics related to overall survival (OS) in GC patients. Immunohistochemistry (IHC) was used to evaluate the impact of RGS1 on prognosis in the study population in our center. Results: The expression level of RGS1 in GC were significantly higher comparing with normal stomach tissues (p=0.016). The expression of RGS1 was significantly associated with poor differentiation (p=1.917e-06), T stage (p=1042e-04), N stage (p=0.049) and TNM stage (p=0.004). The area under the ROC curve was 0.610. High RGS1 expression was significantly associated with poor OS (p=0.002). Multivariate analysis shows high RGS1 expression(p=0.031) was independent poor prognostic factors of OS. Conclusion: High RGS1 protein expression was correlated with poor clinical outcomes, which was also independent predictors of worse OS. RGS1 may be a promising target for a new GC therapy.
Misclassification of Gleason grade and tumor stage in Asian-American patients with low-risk prostate cancer: A SEER-Based Analysis
Authors: Li Xiao , Xu Zicheng , Xu Wenbo , Qi Feng , Zou Qing 
Published: November 2021

Abstract
Background
This study aimed to investigate the misclassification rates of Asian-American patients with low-risk prostate cancer who underwent radical prostatectomy (RP).
Methods
Patients diagnosed with low-risk PCa treated with RP between 2010 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were included in this study. Then, basic characteristics and pathological outcomes of enrolled patients were retrospectively extracted. We compared the rates of upgrading and/or upstaging between Asian-American patients and White/Black patients. Moreover, temporal trend analyses were performed to explore the changes in upgrading and upstaging rates in each race over time. Finally, logistic regression models were constructed to explore the role of Asian race in upgrading and upstaging and to screen out potential risk factors for predicting upgrading and upstaging in Asian-American patients.
Results
In patients with low-risk PCa, Asian-Americans had significantly higher rate of upgrading than Whites (51.25% vs. 45.18%, P<0.001), while no statistical difference was found in the comparison of upstaging rate (10.01 vs. 10.01, P=0.536). Moreover, Asian-Americans were more likely to upgrade to diseases with higher ISUP grade than Whites (P=0.010). The rate of upgrading increased significantly over time in White and Black patients, but not in Asian-American patients. Finally, race seemed to be an independent risk factor for predicting upgrading, while the racial differences seemed to be more pronounced between White and Black patients.
Conclusion
Asian-American patients had a significantly higher rate of upgrading than White patients. Moreover, Asian-American patients were more likely to upgrade to diseases with higher ISUP grade. Further risk assessment before clinical decision for low-risk PCa patients with the help of significant clinical variables is required.
Sex Differences in Depressive Symptom Networks Among Community-Dwelling Older Adults in South Korea: A Network Comparison Test
Authors: Lee Chiyoung , Hu Xiao 
Published: November 2021

Abstract
This cross-sectional study investigated the sex differences in depressive symptom networks among community-dwelling older adults in Korea. The analysis was based on the 2019 Korean Community Health Survey data targeting older adults aged 65 years or older. Using network analysis, depressive symptom networks were constructed according to the items listed in the Patient Health Questionnaire-9 for propensity score-matched male (n = 1,885) and female groups (n = 2,848). Strength centrality and network stability were tested. A network comparison test was performed to compare the global strength, network structure, and specific edge strength between the networks. Symptoms central to the network were similar between sexes, which were suicidal ideation, hopelessness, and psychomotor retardation/agitation. However, the global structure (S = 0.67, p = .008) and network structure (M = 0.11, p = .043) differed between sexes. The female symptom network showed more strengthened edges (Smale = 2.00; Sfemale = 2.66). Particularly, four edges—loss of interest–hopelessness (E = 0.09, p = .016), sleep disturbance–low energy/fatigue (E = 0.11, p = .005), loss of interest–concentration difficulty (E = 0.05, p = .047), and worthlessness–concentration difficulty (E = 0.08, p = .045)—were more pronounced in the female network. Our results may help guide future research and clinical interventions for female depression.
Knockdown of TRAF1 in NSCIC Contributes Gefitinib Sensitivity by Promoting G2/M Cell Cycle Arrest
Authors: Wen Xiaoxing , Zhang TingTing , Feng Tao , Wang Bingping , Fang Tao 
Published: November 2021

Abstract
Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) achieves remarkable success in the treatment of patients with advanced non-small cell lung cancer (NSCLC) bearing activating EGFR mutations. However, EGFR-TKI resistance is still a obstacles in the clinical practice. TRAF1 as a member of TRAF family participates NSCLC progression. In our previous research found that TRAF1 played an important role in the progression of NSCLC.Methods: In vivo and vitro, quantitative PCR (qPCR) and western blot (WB) were carried out to check the expression of TRAF1 in gefitinib-sensitive and -resistant NSCLC samples. The cell counting kit-8 (CCK8) and flow cytometry were used to measure cell proliferation, apoptosis and cycle arrest.Results: Here we showed that TRAF1 over-expression is associated with clinical resistance to EGFR TKI. TRAF1 was significantly up-regulated in gefitinib-resistant cells. Knockdown of TRAF1 increased the sensitivity of gefitinib-resistant cell. Knockdown of TRAF1 induced cell apoptosis and cell cycle arrest. Conclusions: Therefore, our results highlight the function of TRAF1 in the EGFT-TKI resistance.
Dynamic Three-Dimensional Shoulder Kinematics In Patients With Massive Rotator Cuff Tears: A Comparison of Patients With And Without Subscapularis Tears
Authors: Yamada Yuji , Kai Yoshihiro , Kida Noriyuki , Koda Hitoshi , Ikeda Hitoshi , Takeshima Minoru , Hoshi Kenji , Gamada Kazuyoshi , Morihara Toru 
Published: November 2021

Abstract
Background: Massive rotator cuff tears (MRCTs) with subscapularis tears cause severe shoulder dysfunction. This study aimed to examine the influence of subscapularis tears on 3D shoulder kinematics during scapular plane abduction in patients with MRCTs.Methods: Fifteen patients were enrolled and were divided into two groups: supraspinatus and infraspinatus tears either with subscapularis tear (Torn Subscapularis group: 10 shoulders) or without subscapularis tear (Intact Subscapularis group: 5 shoulders). Single-plane fluoroscopic images during scapular plane elevation and computed tomography-derived 3D bone models were matched to the fluoroscopic images using 2D/3D registration techniques. Changes in 3D kinematic results were compared.Results: The humeral head center at the beginning of arm elevation was significantly higher in the Torn Subscapularis group than in the Intact Subscapularis group (1.8 ± 3.4 mm vs. −1.1 ± 1.6 mm, respectively, P < 0.05). In the Torn Subscapularis group, the center of the humeral head migrated superiorly, then significantly downward at 60° arm elevation (P < 0.05). In the Intact Subscapularis group, there was no significant difference in the superior-inferior translation of the humeral head between the elevation angles.Conclusions: In cases of MRCT with a torn subscapularis, the center of the humeral head showed a superior translation at the initial phase of scapular plane abduction, subsequently, there was inferior translation. These findings suggest that the subscapularis muscle plays an important role in determining the glenohumeral joint’s dynamic stability in a superior-inferior direction in patients with MRCTs.
Diagnosis of Breast Sparganosis by Ultrasonography Combine with Molecular Biological Methods
Authors: Yang Ping , Zheng Wei , Wang Lifu 
Published: November 2021

Abstract
Background: Sparganosis is a parasitic zoonosis caused by the plerocercoid larvae of the genus Spirometra. The sites affected by the plerocercoid infection include subcutaneous tissues, brain, eyes, the abdominal viscera, and urogenital organs. In clinical practice, due to the limited laboratory approaches for the specific detection of sparganum, breast Sparganosis was often initially suspected to be breast tumor. Case presentation: In the present report, a 65-year-old woman was admitted to the Sun Yat-sen University Cancer Center, Guangzhou, China, because of a mass in her left breast. Breast ultrasonography showed multiple bands with low echo and uneven echo, and color doppler flow imaging showed no blood flow signal in the lesion. Therefore, the possibility of tumor was excluded and a preliminary diagnosis of Sparganosis was made. Subsequently, a lumpectomy was carried out and revealed a 30 cm worm. Then histopathological examination diagnosed this case was sparganosis and the worm was Sparganum proliferum. To further verify our diagnosis, the cytochrome oxidase subunit 1 (COX1) gene was amplified by PCR, sequence analysis of PCR products made us sure that it was the Sparganum proliferum. Conclusion: We present Sparganosis could be preliminarily distinguished from breast tumor by ultrasonography, and then confirm Sparganosis by molecular biological methods, which provided a more efficient method for the detection of Sparganosis.