bluuebunny/crossref_metadata_2025_split huggingface dataset:
REPRODUKSI BUDAYA DALAM PENTAS KESENIAN TRADISIONAL DI BALAI SOEDJATMOKO
Authors: Nukha Rosyid 
Published: May 2021

<p><em>The aim of this research is to know about the culture reproduction process that happen ang to know the actor on the traditional art perfromances in Soedjatmoko Hall. This is a qualitative research with case study as its approach. The data collection done by interview, participatory observation ang documentation. The primary data collected by indepth interview and participatory observation. That data being analyzed using interactive model. The data validity done by source triangulation. the art performance reproduction is being analyzed by Pierre Bourdieu’s theory. The research found that the actors in the culture reproduction on traditional art performances include keroncong art groups, kararwitan art groups, macapat art groups and Soedjatmoko Hall. Those actor have cultural capital, social capital, symbolic capital and economic capital that supported the reproduction process. Culture reproduction in the traditional art through Keroncong Bale, Macapat Soedjatmakan, dan Klenengan Selasa Legen art performance by perform again the traditonal art. Reproduction process happen through the use of pakem and the use of symbol, the delivery of meaning in the art performance, performance’s procedures, the songs and the materials is adjusted to the pakem.</em></p><p><strong><em>Keywords:</em></strong><em> <strong>Soedjatmoko Hall, Culture Reproduction, Art Performance.</strong></em></p><p> </p><p><strong>Abstrak</strong></p><p>Penelitian ini bertujuan untuk mengetahui proses reproduksi budaya yang terjadi dan mengetahui aktor yang terlibat dalam pementasan kesenian tradisional di Balai Soedjatmoko. Jenis penelitian ini adalah kualitatif dengan strategi studi kasus. Pengumpulan data dilakukan dengan wawancara, observasi partisipatif, dan dokumentasi. Data primer dikumpulkan melalui wawancara mendalam dan observasi partisipatif. Analisis data menggunakan model interaktif. Validitas data menggunakan reviu informan dan trianggulasi sumber. Reproduksi kesenian tradisional di Balai Soedjatmoko dikaji dengan pemikiran Pierre Bourdieu. Hasil penelitian menunjukkan Aktor-aktor yang terlibat dalam reproduksi budaya pada pementasan kesenian tradisional meliputi kelompok kesenian keroncong, kelompok kesenian karawitan, kelompok kesenian macapat, dan Balai Soedjatmoko. Aktor kesenian tradisional tersebut memiliki modal budaya, modal sosial, modal simbolik, dan modal ekonomi yang mendukung proses reproduksi. Reproduksi budaya dalam kesenian tradisional melalui penyelenggaraan pentas kesenian Keroncong Bale, Macapat Soedjatmakan, dan Klenengan Selasa Legen dengan mementaskan kembali kesenian tradisional yang sudah berkembang. Proses reproduksi yang terjadi melalui penggunaan pakem yang baku serta penggunaan simbol, penyampaian makna dalam pementasan kesenian, tata cara pementasan, lagu yang dibawakan dan materi yang dipilih dilestarikan sesuai dengan pakemnya.</p><p><strong>Kata Kunci: Balai Soedjatmoko, Reproduksi Budaya, Kesenian Tradisional.</strong></p>
Assessment of the Ground and Plant Chemistry in an Area Affected by Rare Metal Ore Concentration Waste Storage
Authors: Krasavtseva Eugenia , Maksimova Viktoria , Gorbacheva Tamara 
Published: May 2021

Abstract
This paper presents the results of an assessment of the ground and plant chemistry in disturbed areas exposed to impacts from adjacent rare metal ore concentration waste storage facilities.The focus of research were areas with sparse vegetation cover near the site of the first tailing storage facility (TSF), which is not exploited from 1985. In the summer of 2019, on three key plots within the study area, plant samples were collected at a small distance from the TSF and operating process transport routes (<1 km). Based on a bulk chemistry analysis of the ground samples, concentration values were measured above the background values adopted for the region’s soil parent rock materials, and in the absence thereof, the clarkes of elements in acidic (SiO2 >60%) rocks found in the earth's crust. Grounds were found to be rich in Ta, Ce, La, Th, Zr, Nb, which are also present in the loparite ores of various origins mined by the operation.The chemistry was examined of Salix spp. commonly found both in the study area and in the region as a whole and of wavy hair grass Avenella flexuosa L. An abnormally high level of zinc accumulation was observed in Salix lapponum (>850 mg/kg, biological absorption coefficient (BAC) >4), and technological transport influence was proposed as a possible cause. High paired correlation coefficients of rare and trace elements with Al and with each other (>0.9) in the bulk chemistry analysis of Salix spp. indicate the likelihood of deposition of minerogenetic dust particles. Based on the observed values of the BAC, the plants were classified into biological accumulation (BAC >1) and biological uptake (BAC <1) classes and the latter was found to be dominant.
Weight Loss is Associated with Changes in Gut Microbiome: A Randomized, Cross-Over Trial Comparing a Mediterranean and a Low-Fat Vegan Diet in Overweight Adults.
Authors: Kahleova Hana , Rembert Emilie , Alwarith Jihad , Nowak Amber , Agnello Melissa , Chutkan Robynne , Holubkov Richard , Barnard Neal D. 
Published: May 2021

Abstract
Background: Mediterranean and vegan diets improve body weight and gut microbiome composition. The aim of this study was to compare both diets head-to-head. Methods: Randomized cross-over trial, conducted February-October 2019. Sixty-two overweight adults were assigned to each diet for 16-week periods in random order, separated by a 4-week washout. Body weight was the primary outcome. Secondary measures included changes in gut microbiome which was measured using 16S rRNA sequencing. Results: Body weight decreased on the vegan compared with the Mediterranean diet (treatment effect -6.0 kg [95% CI -7.5 to -4.5]; p<0.001). The relative abundance of Bacteriodetes decreased (p<0.001 for both diets) and Eubacteria increased on both diets (p<0.001 for the Mediterranean and p=0.009 for the vegan diet). The relative abundance of Lachnospiraceae increased (p=0.03), the Firmicutes to Bacteroidetes ratio increased (p=0.04) and the butyrate-producing bacteria decreased (p=0.02) on the Mediterranean diet. The relative abundance of Proteobacteria decreased (p<0.001), and Enterobacteria and Ruminococcus increased on the vegan diet (p=0.04 and p<0.001, respectively). Changes in body weight correlated positively with changes in relative abundance of Firmicutes both on the Mediterranean (r=+0.36; p=0.01) and the vegan diet (r=+0.41; p<0.001) and with changes in relative abundance of Lachnospiraceae both on the Mediterranean (r=+0.40; p<0.001) and the vegan diet (r=+0.44; p<0.001). In addition, the changes in body weight correlated negatively with changes in relative abundance of Enterobacteria on the Mediterranean diet (r=-0.32; p=0.02) and Eubacteria on the vegan diet (r=-0.49; p<0.001).Conclusions: A low-fat vegan diet led to a greater weight loss compared with a Mediterranean diet. This may be partly explained by the difference in gut microbiome composition.Trial registration: ClinicalTrials.gov number, NCT03698955
Evaluation of Tannery Wastewater Treatment by Integrating Vesicular Basalt with Local Plant Species in a Constructed Wetland System
Authors: Alemu Agegnehu , Gabbiye Nigus , Lemma Brook 
Published: May 2021

Abstract
Tannery wastewater is composed of a complex mixture of organic and inorganic components from various processes that can critically pollute the environment especially water bodies if discharged without treatment. In this study, integrated vesicular basalt rock and local plant species were used to establish a horizontal subsurface flow constructed wetland system and to investigate the treatment efficiency of tannery wastewater. Four pilot units were vegetated with P. purpureum, T. domingensis, C. latifolius, and E. pyramidalis, and a 5th unit was left unvegetated (control). The constructed wetland units in horizontal subsurface flow systems were effective in removing total Cr, COD, and BOD5 from the inflow tannery wastewater. The removal efficiency reached up to 99.38 %, 84.03 %, and 80.32% for total Cr, COD, and BOD5 respectively in the 6 days of HRT. The removal efficiency of TSS, TP, and NO3− obtained a maximum of 70.59 %, 62.32 %, and 71.23 % respectively. This integrated system was effective for removing tannery wastewater, which is below the Ethiopian surface water standard discharge limit set to BOD (200 mg L− 1), COD (500 mg L− 1), total Cr (2 mg L− 1), NO3− (20 mg L− 1), TSS (50 mg L− 1), and TP (10 mg L− 1).
Mitochondrial uncoupling protein contributes to the regulation of carbon and nitrogen metabolism and seed yield under low nitrogen stress in Arabidopsis
Authors: Qiao Xinyan , Yu Tao , Ruan Mengjiao , Cui Chaiyan , Chen Cuiyun , Zhu Yuanzhi , Li Fanglin , Wang Shengwang , Na Xiaofan , Wang Xiaomin , Bi Yurong 
Published: May 2021

Abstract
Nitrogen (N) availability is a critical factor for plant development and yield, and it closely correlates to carbon (C) metabolism. Uncoupling protein (UCP) and alternative oxidase (AOX) in mitochondria exhibit a strong correlation with N and C metabolism. Here, we investigated the respective functions of UCP and AOX by using ucp1, aox1a and aox1a/ucp1 mutants under low-N condition. Low-N markedly increased AOX1a and UCP1 expression, alternative pathway capacity and UCP activity. Eight-day-old aox1a/ucp1 seedlings were more sensitive to low-N condition than Col-0 and single mutants, i.e., the lower primary root length and higher anthocyanin accumulation. The net photosynthetic rate (A) and electron transport rate (ETR) under low-N stress were markedly decreased in ucp1 and aox1a/ucp1 compared to those in Col-0, but not in aox1a. The leaf area, total C and N content in shoots showed a similar profile as A and ETR. Nitrate acquisition rate was accelerated in aox1a/ucp1, but its transport activity from root to shoot was decreased, which resulted in the low nitrate content and nitrate reductase activity in shoots upon low-N condition. Additionally, the low C and N content in ucp1 and aox1a/ucp1 seeds led to the decreased seed yield compared to Col-0 upon low-N stress. RNA-seq analysis revealed that a large number of genes involved in photosynthesis, C/N metabolism were markedly down-regulated in aox1a/ucp1 compared to Col-0 under low-N stress. These results highlight the more key role of UCP1 than AOX1a in modulating C and N metabolism and seed yield in Arabidopsis adaptation to low-N stress.
Frequency-Dependent Seedling Predation by Rodents: Growth and Survival of Quercus Wutaishanica in Two Habitats
Authors: Zhang Jinfeng , Yan Xingfu , Dayananda Buddhi , Luo Yonghong , Li Junqing 
Published: May 2021

Abstract
Background: The preference of a predator for a certain type of prey affects the fitness of species in nature, the optimal foraging theory predicted that prey density may change the predator’s selection preferences, furthermore, predation on prey may be frequency-dependent. However, there are few studies demonstrate that how such frequency-dependent selection influences predator-prey dynamics, especially in plants. Methods: We tested the frequency-dependent preying on Quercus wutaishanica seedlings by rodents and seedlings' survival and growth in different habitats. We transplanted seedlings with five frequency of large and small seed (FLSD) (9:1, 7:3, 5:5, 3:7, 1:9) in the forest gap and under the canopy in a warm temperate forest in the Liupan Mountains, northwest, Ningxia, China. Results: (1) Rodents prefer the cotyledon of seedlings established from large seeds with more nutrients in the early stage of transplanting. Nonetheless, we found the net effect of rodent predation to be positively frequency-dependent, and this predation effect should function as a species coexistence promoting mechanism. (2) The seedling cotyledon retention rate has the maximum fitness when the FLSD was almost the same, which can provide energy for the growth of seedlings of different phenotypes and ensure their survival as much as possible. (3) Only the cotyledons were preyed on, the apical buds were bitted off, and the whole seedling was uprooted, which mostly occurred under the forest canopy, but the survival rates of cotyledon-predated seedling, apical bud-predated seedling, and intact seedling in the forest gap were higher than those under the canopy, indicating rodents prefer to active or prey under the hidden forest canopy, but the forest gap can provide suitable light for seedling growth and survival. (4) If only cotyledons were preyed on, the growth of Q. wutaishanica seedling would not be affected. Although it is not fatal to bite off the seedling apical bud, the growth is still hindered. Conclusion: These results of this experiment enrich the theory of "frequency dependence", and provide new insights into the coexistence between rodents and seedlings established different seed phenotypes. Furthermore, it also better reveals the ecological characteristics of deciduous Quercus regeneration.
Transsphenoidal Pituitary Adenoma Resection: Do Early Post-Operative Cortisol Levels Predict Permanent Long-Term Hormone Deficiency?
Authors: Butenschoen Vicki Marie , von Werder Alexander , Bette Stefanie , Schmette Veronika , Schwendinger Nina , Meyer Bernhard , Gempt Jens 
Published: May 2021

Abstract
Objective: Transsphenoidal surgery provides a minimal invasive treatment for pituitary adenoma. Our aim is to evaluate the endocrinological outcomes after adenoma resection, and to identify prognostic factors for an impaired hypothalamic-pituitary-adrenal- axis function -(HPA) and the reliability of postoperative early morning serum cortisol measurements.Methods: Retrospective analysis of all patients treated for pituitary adenoma from April 2006 to January 2019 in our neurosurgical department. Pituitary function was assessed pre- and postoperatively as well as at 6 weeks to 12 weeks and at 1-year follow-up.Results: 211 patients were included. 9% of the patients recovered from a preoperative adrenal insufficiency, 10.4% developed a new need for hormone substitution, and a long-term deficiency of the hypothalamic-pituitary-adrenal-axis was observed in 30.9%. Cortisol measurements 5 days after surgery had a lower area under the curve (AUC) than cortisol levels detected after 6 to 12 weeks (AUC 0.740 vs. AUC 0.808) in predicting a secondary adrenal insufficiency. The cut-off value determined for cortisol measured after 6 weeks was 6.95 µg/dl (sensitivity of 94%, specificity of 68%).Conclusion: Postoperative early morning cortisol levels seem to be less sensitive and specific in predicting long-term hormone deficiency than measurements after 6 weeks and 1 year, emphasizing the importance of endocrine follow-up testing.
Malicious URL Detection Algorithm Based on Multi Neural Network Series
Authors: Xiu Weirong , Bian Chen , Wu Chunhui 
Published: May 2021

Abstract
Abstract: Convolutional neural network based on attention mechanism and a bidirectional independent recurrent neural network tandem joint algorithm (CATIR) are proposed. In natural language processing related technologies, word vector features are extracted based on URLs, and the extracted URL information features and host information features are merged. The proposed CATIR algorithm uses CNN (Convolutional Neural Network) to obtain the deep local features in the data, uses the Attention mechanism to adjust the weights, and uses IndRNN (Independent Recurrent Neural Network) to obtain the global features in the data. The experimental results shows that the CATIR algorithm has significantly improved the accuracy of malicious URL detection based on traditional algorithms to 96.9%.
Keywords: Malicious URL; CATIR; word vector feature; detection
Oridonin relieves depressive-like behaviors by inhibiting neuroinflammation and autophagy impairment in rats subjected to chronic unpredictable mild stress
Authors: Liang Liang , Wang Gaohua , Wang Hui , Bian Hetao , Xiao Ling 
Published: May 2021

Abstract
Background: Major depressive disorder (MDD) is a common, chronic, and severe life-threatening disorder with increasing prevalence. Although neuroinflammation is associated with the etiology of depression, the mechanistic interplay between depression, neuroinflammation, and autophagy is yet to be demonstrated. This study investigated the effect of Oridonin on CUMS-induced neuroinflammation, depression, and autophagy impairment. Methods: Male 4-week-old Sprague-Dawley rats were subjected to chronic unpredictable mild stress (CUMS) for 4 and 6 weeks respectively, some of which were injected with Oridonin, fluoxetine (FLX) or their combination at different durations of CUMS. After CUMS procedure, sucrose preference test and Forced swim test were used to evaluate depressive-like behaviors. Concomitant neuroinflammation changes and autophagy impairments were examined in the hippocampus.Reults: In this study, we found that chronic stress resulted in depressive-like behaviors and caused neuroinflammation and autophagy impairment. In particular, CUMS treatment significantly increased the levels of cytokines (IL-1β, IL-18 and Caspase-1), reduced autophagy-related protein levels (Beclin-1, p62, Atg5 and LC3B), caused microglia cells activation. Oridonin treatment can prevent and reverse the depressive-like behavior induced by CUMS in prophylactic and therapeutic administration, but there is ceiling effect in the treatment process. Furthermore, 10mg/kg dose of Ori has a stronger and longer lasting antidepressant effect than the 10mg/kg dose of fluoxetine. And the antidepressant effect of Ori in combination with fluoxetine was greater than that of high-dose fluoxetine alone. In addition, Ori treatment significantly normalized autophagy-related protein levels, and reduced levels of cytokines via blocking the interaction between NLRP3 and NEK7. Further, we investigated the role of autophagy in LPS-activated BV2 cells and levels of cytokines. Similarly, Oridonin treatment abolished and reversed levels of cytokines and autophagy-related protein levels.Conclusions: All these results supported our hypothesis that Ori possesses potent anti-depressive action, which might be mediated via inhibition of neuroinflammation and autophagy impairment through blocking the interaction between NLRP3 and NEK7.
Shedding of Glycocalyx Components in Neuromyelitis Optica: Initial Predictor of Immune Attack?
Authors: Zhang Qi , Pei Shanshan , Chen Jinyu , Peng Yu , Zhou Zheyi , Wang Zhanhang , wang honghao 
Published: May 2021

Abstract
Background: Neuromyelitis optica (NMO), multiple sclerosis (MS) and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy are idiopathic inflammatory demyelinating diseases (IIDDs) that mainly present as encephalomyelitis. Heparan sulfate (HS) and hyaluronic acid (HA) are two components of glycocalyx, a carbohydrate-rich layer on the surface of blood vessels that mediates interaction with blood. Degradation of glycocalyx in IIDDs is poorly understood. Purpose: To detect the serum and cerebrospinal fluid (CSF) levels of shed HS and HA and to correlate these levels with disease severity to determine their diagnostic value. Methods: We obtained serum and CSF samples from 24 NMO patients, 15 MS patients, 10 autoimmune GFAP astrocytopathy patients, and 18 controls without non-inflammatory neurological diseases. Soluble HS and HA, and IFNγ, IL17A, and matrix metalloproteinase (MMP) 1 were detected via ELISA. Results: Serum and CSF levels of HS, HA and related cytokines but not of plasma MMP1 were significantly elevated in these diseases. Notably, HS and HA levels were positively correlated with Expanded Disability Status Scale scores. Conclusions: Our results indicate glycocalyx degradation and inflammation in NMO, MS and autoimmune GFAP astrocytopathy. Moreover, increased shedding of HS or HA may indicate a worse clinical situation. Furthermore, therapeutic strategies that protect glycocalyx may be effective in these diseases.
β-Elemene Prevented Multidrug Resistance of Small Cell Lung Cancer Cell Line H446: Targeting the Autophagy Regulation of MiR-199a-5p is the Mechanism of Cisplatin Resistance.
Authors: Li Tiezhi , Zhang Helin , Wang Zhichao , Gao Shaolin , Zhang Xu , Zhu Haiyong , Wang Na , Li Honglin 
Published: May 2021

Abstract
Background Multidrug resistance (MDR) in small cell lung cancer (SCLC) is a clinical dilemma in chemotherapy. A natural compound, β-elemene has been found to inhibit MDR cancers. We hypothesized that β-elemene regulated cisplatin-resistant SCLC by targeting autophagy-related miRNA miR-199a-5p. Methods We assessed the IC50 of multiple chemotherapeutic agents toward SCLC cells H446 and MDR SCLC cells H446/EP with or without β-elemene using CCK-8. We overexpressed (OE) and knocked down (KD) miR-199a-5p in H446 and H446/EP and determined the expression of miR-199a-5p, autophagy-related proteins, and the formation of autophagolysosomes using QPCR, western blotting, and MDC staining respectively. We validate the binding of miR-199a-5p to p62 using the Dual-Luciferase assay. Results β-Elemene decreased drug resistance of H446 to cisplatin, etoposide, paclitexal, epirubicin, irinotecan, and vinorelbine. Cisplatin increased LC3II/LC3I, ATG5, p62, and the formation of autophagolysosomes in H446 cells, but not in H446/EP cells, and these effects were blocked by β-elemene. The OE of miR-199a-5p reduced cisplatin-induced increase of LC3II/LC3I, ATG5, p62, and the formation of autophagolysosomes while the KD of miR-199a-5p did the opposite. the OE of miR-199a-5p reduced the luciferase signal of wild-type p62, but not that of p62 with mutations at the predicted binding site. The effect of β-elemene on cisplatin-induced autophagy was validated in OE-H446 and KD-H446/EP. Conclusions β-Elemene prevented MDR in H446 and it prevents cisplatin resistance of H446 by targeting the autophagy regulation of miR-199a-5p.
Development and Application of a Duplex-Single Sequence Repeat Panel for Outcrossing Fertility Evaluation in Red Clover Under Open-Pollinating Conditions
Authors: Huang Fan , Qiang Xiaojing , Li Jun , Liu Lei , Wu Zinian , Li Zhiyong 
Published: May 2021

Abstract
Red clover (Trifolium pratense L.) is a globally significant legume having economic value as a forage and green manure crop in temperate agricultural zones. Based on the gametophytic self-incompatibility system, and analysis of seed set rates between self and cross pollination, the clover has long been considered an outcrossing species. However, the outcrossing rates of red clover under open-pollination conditions are not definitive. Development of a reliable, timesaving, and easily usable marker system is needed to quantify and characterize rates of red clover crossing and selfing. Here, genome-wide screening of 209 mapped simple sequence repeat (SSR) markers was conducted, and 185 produced clear scorable bands on a pooled DNA sample of 20 red clover accessions. Seventy markers were selected based on polymerase chain reaction (PCR) amplification quality on 24 genotypes and their relatively even distribution in red clover genome. Mean polymorphic information content for the 70 markers was 0.490, ranging from 0.117 to 0.878. From the markers, a core set of 24 loci, which had been mapped on six linkage groups, was further tested to develop 12 sets of duplex markers. Using the established duplex PCR protocol, 10 out of 12 sets of duplex SSR markers were used to genotype 60 maternal parents and their respective 22 half-sib progenies. Eight plants among the 1,320 progenies were identified to be selfed, indicating that the outcrossing rate was 99.4% in a natural environment. The protocol and the finding of this rare selfing strategy under open-pollinating conditions contribute to red clover breeding efforts.