bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental demonstration of a concave grating for spin waves in the Rowland arrangement
Authors: Papp Ádám , Kiechle Martina , Mendisch Simon , Ahrens Valentin , Sahin Levent , Seitner Lukas , Porod Wolfgang , Csaba Gyorgy , Becherer Markus 
Published: July 2021

AbstractWe experimentally demonstrate the operation of a Rowland-type concave grating for spin waves, with potential application as a microwave spectrometer. In this device geometry, spin waves are coherently excited on a diffraction grating and form an interference pattern that focuses spin waves to a point corresponding to their frequency. The diffraction grating was created by focused-ion-beam irradiation, which was found to locally eliminate the ferrimagnetic properties of YIG, without removing the material. We found that in our experiments spin waves were created by an indirect excitation mechanism, by exploiting nonlinear resonance between the grating and the coplanar waveguide. Although our demonstration does not include separation of multiple frequency components, since this is not possible if the nonlinear excitation mechanism is used, we believe that using linear excitation the same device geometry could be used as a spectrometer. Our work paves the way for complex spin-wave optic devices—chips that replicate the functionality of integrated optical devices on a chip-scale.
Impact of rescanning and repositioning on radiomic features employing a multi-object phantom in magnetic resonance imaging
Authors: Bernatz Simon , Zhdanovich Yauheniya , Ackermann Jörg , Koch Ina , Wild Peter J. , dos Santos Daniel Pinto , Vogl Thomas J. , Kaltenbach Benjamin , Rosbach Nicolas 
Published: July 2021

AbstractOur purpose was to analyze the robustness and reproducibility of magnetic resonance imaging (MRI) radiomic features. We constructed a multi-object fruit phantom to perform MRI acquisition as scan-rescan using a 3 Tesla MRI scanner. We applied T2-weighted (T2w) half-Fourier acquisition single-shot turbo spin-echo (HASTE), T2w turbo spin-echo (TSE), T2w fluid-attenuated inversion recovery (FLAIR), T2 map and T1-weighted (T1w) TSE. Images were resampled to isotropic voxels. Fruits were segmented. The workflow was repeated by a second reader and the first reader after a pause of one month. We applied PyRadiomics to extract 107 radiomic features per fruit and sequence from seven feature classes. We calculated concordance correlation coefficients (CCC) and dynamic range (DR) to obtain measurements of feature robustness. Intraclass correlation coefficient (ICC) was calculated to assess intra- and inter-observer reproducibility. We calculated Gini scores to test the pairwise discriminative power specific for the features and MRI sequences. We depict Bland Altmann plots of features with top discriminative power (Mann–Whitney U test). Shape features were the most robust feature class. T2 map was the most robust imaging technique (robust features (rf), n = 84). HASTE sequence led to the least amount of rf (n = 20). Intra-observer ICC was excellent (≥ 0.75) for nearly all features (max–min; 99.1–97.2%). Deterioration of ICC values was seen in the inter-observer analyses (max–min; 88.7–81.1%). Complete robustness across all sequences was found for 8 features. Shape features and T2 map yielded the highest pairwise discriminative performance. Radiomics validity depends on the MRI sequence and feature class. T2 map seems to be the most promising imaging technique with the highest feature robustness, high intra-/inter-observer reproducibility and most promising discriminative power.
Feature importance correlation from machine learning indicates functional relationships between proteins and similar compound binding characteristics
Authors: Rodríguez-Pérez Raquel , Bajorath Jürgen 
Published: July 2021

AbstractMachine learning is widely applied in drug discovery research to predict molecular properties and aid in the identification of active compounds. Herein, we introduce a new approach that uses model-internal information from compound activity predictions to uncover relationships between target proteins. On the basis of a large-scale analysis generating and comparing machine learning models for more than 200 proteins, feature importance correlation analysis is shown to detect similar compound binding characteristics. Furthermore, rather unexpectedly, the analysis also reveals functional relationships between proteins that are independent of active compounds and binding characteristics. Feature importance correlation analysis does not depend on specific representations, algorithms, or metrics and is generally applicable as long as predictive models can be derived. Moreover, the approach does not require or involve explainable or interpretable machine learning, but only access to feature weights or importance values. On the basis of our findings, the approach represents a new facet of machine learning in drug discovery with potential for practical applications.
Human blood microRNA hsa-miR-21-5p induces vitellogenin in the mosquito Aedes aegypti
Authors: Perdomo Hugo D. , Hussain Mazhar , Parry Rhys , Etebari Kayvan , Hedges Lauren M. , Zhang Guangmei , Schulz Benjamin L. , Asgari Sassan 
Published: July 2021

AbstractMosquito vectors transmit various diseases through blood feeding, required for their egg development. Hence, blood feeding is a major physiological event in their life cycle, during which hundreds of genes are tightly regulated. Blood is a rich source of proteins for mosquitoes, but also contains many other molecules including microRNAs (miRNAs). Here, we found that human blood miRNAs are transported abundantly into the fat body tissue of Aedes aegypti, a key metabolic center in post-blood feeding reproductive events, where they target and regulate mosquito genes. Using an artificial diet spiked with the mimic of an abundant and stable human blood miRNA, hsa-miR-21-5p, and proteomics analysis, we found over 40 proteins showing differential expression in female Ae. aegypti mosquitoes after feeding. Of interest, we found that the miRNA positively regulates the vitellogenin gene, coding for a yolk protein produced in the mosquito fat body and then transported to the ovaries as a protein source for egg production. Inhibition of hsa-miR-21-5p followed by human blood feeding led to a statistically insignificant reduction in progeny production. The results provide another example of the involvement of small regulatory molecules in the interaction of taxonomically vastly different taxa.
Soluble (pro)renin receptor: a novel ligand for angiotensin II type 1 receptor?
Authors: Torimoto Keiichi , Eguchi Satoru 
Published: July 2021

Abstract
This commentary highlights the study entitled ‘Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor’ presented by Fu et al. published in Clinical Science (Clin Sci (Lond) (2021) 135(6), https://doi.org/10.1042/CS20201047). The authors evaluated the role of the soluble (pro)renin receptor (sPRR), a cleavage product of the prorenin receptor (PRR) by the site 1 protease, as a ligand for angiotensin II type 1 receptor (AT1R). They presented for the first time that sPRR directly interacts with AT1R, causing nuclear factor-κB activation, inflammation, apoptosis, and endothelial dysfunction in primary human umbilical vein endothelial cells (HUVECs). Furthermore, the interaction between sPRR and AT1R was responsible for endothelial dysfunction and hypertension in diet-induced obesity mice. These results provide a potential mechanism for obesity-induced endothelial dysfunction and hypertension. Thus, the sPRR/AT1R complex may be a novel therapeutic target for cardiovascular diseases associated with endothelial dysfunction.
Design of a novel CEM‐FRM‐based low‐complexity channelised radar transmitter
Authors: Zhang Wenxu , Cui Xinlei , Yu Yongzhi , Yuan Binghua 
Published: July 2021

AbstractWith the development of the radar technology, it is required that a radar has wider bandwidth and can transmit multiple signals simultaneously. The polyphase digital channelised transmitter structure can transmit multiple signals simultaneously and increase the bandwidth of the output signal. However, in order to reduce the frequency aliasing and improve the spectrum utilisation, the prototype filter needs to have sharp transition bandwidth. The design of the prototype filter directly affects the performance of the radar transmitter. Using the complex‐exponential modulation frequency‐response masking (CEM‐FRM) approach to design the prototype filter can obtain both sharp transition bandwidth and low complexity. The application of a polyphase structure can further reduce the complexity of the filter bank and make the sampling rate of the output signal several times the field programmable gate array operating frequency. The proposed CEM‐FRM‐based low complexity polyphase channelised radar transmitter is verified by MATLAB simulation and the theoretical complexity of the proposed CEM‐FRM‐based channelised radar transmitter structure is compared with other methods.
Well-balanced treatment of gravity in astrophysical fluid dynamics simulations at low Mach numbers
Authors: Edelmann P. V. F. , Horst L. , Berberich J. P. , Andrassy R. , Higl J. , Leidi G. , Klingenberg C. , Röpke F. K. 
Published: July 2021

Context.Accurate simulations of flows in stellar interiors are crucial to improving our understanding of stellar structure and evolution. Because the typically slow flows are merely tiny perturbations on top of a close balance between gravity and the pressure gradient, such simulations place heavy demands on numerical hydrodynamics schemes.Aims.We demonstrate how discretization errors on grids of reasonable size can lead to spurious flows orders of magnitude faster than the physical flow. Well-balanced numerical schemes can deal with this problem.Methods.Three such schemes were applied in the implicit, finite-volume SEVEN-LEAGUEHYDROcode in combination with a low-Mach-number numerical flux function. We compare how the schemes perform in four numerical experiments addressing some of the challenges imposed by typical problems in stellar hydrodynamics.Results.We find that theα-βand deviation well-balancing methods can accurately maintain hydrostatic solutions provided that gravitational potential energy is included in the total energy balance. They accurately conserve minuscule entropy fluctuations advected in an isentropic stratification, which enables the methods to reproduce the expected scaling of convective flow speed with the heating rate. The deviation method also substantially increases accuracy of maintaining stationary orbital motions in a Keplerian disk on long timescales. The Cargo–LeRoux method fares substantially worse in our tests, although its simplicity may still offer some merits in certain situations.Conclusions.Overall, we find the well-balanced treatment of gravity in combination with low Mach number flux functions essential to reproducing correct physical solutions to challenging stellar slow-flow problems on affordable collocated grids.
The Convalescent Plasma Craze! Where Does India Stand?
Authors: Priyadarsini Arcot J. , Karan Kumar , Arulselvi Subramanian 
Published: July 2021

AbstractIndia becomes the country with second highest number of coronavirus disease 2019 (COVID-19) cases (59,03,932) as of September 2020. As the world debates various treatment options, the current pandemic has led to the resurgence of an ancient technique, namely convalescent plasma therapy. Although it has been in use from the late 19th century, it is an uncharted territory for most developing nations. In this article, we have discussed the pros and cons of convalescent plasma transfusion in COVID-19 patients. Articles discussed in this review have been obtained from search engines, namely PubMed, Scopus, and Embase. We have also expressed our viewpoint on the feasibility and logistical challenges of convalescent plasma use in India.
Renal Dysfunction in Prediabetes: Confirmed by Glomerular Hyperfiltration and Albuminuria
Authors: Shilpasree Alagilawada S. , Patil Vidya S. , Revanasiddappa Manjunath , Patil Vijayetha P. , Ireshnavar Deepti 
Published: July 2021

Abstract
Objectives Prediabetes is defined as an intermediate state of hyperglycemia with glucose levels above normal but below the diagnostic cutoff of diabetes mellitus. Prediabetes is considered as an important risk factor for the development of diabetes and complications associated with diabetes. Since glomerular hyperfiltration (elevated GFR) and albuminuria represent early and reversible stages of kidney damage seen in patients with type 2 diabetes, we aim to assess the impact of hyperglycemia in prediabetic range on renal functions measured by estimated GFR and urine albumin excretion (UAE).
Materials and Methods The study included 1,031 patients aged 30 to 70 years, attending regular health checkup. Patients were grouped as normal, prediabetes, and diabetes according to the American Diabetic Association (ADA) criteria based on fasting blood sugar and hemoglobin A1c (HbA1c). Further, the patients were grouped into multiple subgroups based on age and gender. UAE was measured by using immunoturbidimetric method, and GFR was estimated by chronic kidney disease epidemiology collaboration (CKD EPI) equation.
Statistical Analysis Prevalence of hyperfiltration (estimated glomerular filtration rate above the age and gender specific 95th percentile), and albuminuria in prediabetes and diabetes was compared with normal controls. Odds ratio and 95% confidence interval were calculated by using logistic regression analysis to predict the occurrence of hyperfiltration in prediabetes and diabetes. Analysis of variance followed by post hoc comparison was done to assess the significance of difference, and p-value < 0.05 was considered statistically significant.
Results Prevalence of hyperfiltration was more in prediabetes and diabetes compared with normal controls, and it increased with surging HbA1c level that was shown as higher odds ratio for hyperfiltration in both the groups. UAE was more in the prediabetes and diabetes group when compared with normal controls, but the difference was significant only in diabetes.
Conclusion Since glomerular hyperfiltration represents an early and reversible stage of renal damage manifesting before the appearance of albuminuria, elevated GFR can be used to identify asymptomatic patients with intermediate hyperglycemia having high risk of developing nephropathy in the future. Prediabetes represents a window of opportunity to initiate preventive strategies at an early stage before the occurrence of significant renal damage.
Development of an Instrument for Assessing the Maturity of Citizens for Consumer Health Informatics in Developing Countries: The Case of Chile, Ghana, and Kosovo
Authors: Yakubu Abubakari , Paloji Fortuna , Bonnet Juan Pablo Guerrero , Wetter Thomas 
Published: July 2021

Abstract
Objective We aimed to develop a survey instrument to assess the maturity level of consumer health informatics (ConsHI) in low-middle income countries (LMIC).
Methods We deduced items from unified theory of acceptance and use of technology (UTAUT), UTAUT2, patient activation measure (PAM), and ConsHI levels to constitute a pilot instrument. We proposed a total of 78 questions consisting of 14 demographic and 64 related maturity variables using an iterative process. We used a multistage convenient sampling approach to select 351 respondents from all three countries.
Results Our results supported the earlier assertion that mobile devices and technology are standard today than ever, thus confirming that mobile devices have become an essential part of human activities. We used the Wilcoxon Signed-Rank Test (WSRT) and item response theory (IRT) to reduce the ConsHI-related items from 64 to 43. The questionnaire consisted of 10 demographic questions and 43 ConsHI relevant questions on the maturity of citizens for ConsHI in LMIC. Also, the results supported some moderators such as age and gender. Additionally, more demographic items such as marital status, educational level, and location of respondents were validated using IRT and WSRT.
Conclusion We contend that this is the first composite instrument for assessing the maturity of citizens for ConsHI in LMIC. Specifically, it aggregates multiple theoretical models from information systems (UTAUT and UTAUT2) and health (PAM) and the ConsHI level.
Dural Arteriovenous Fistula within Superior Sagittal Sinus Wall with Direct Cortical Venous Drainage: A Systematic Literature Review
Authors: Chavan Rajendra , Sethi Shreya , Sahu Harsha , Rao Neeraj , Agarwal Shivani 
Published: July 2021

AbstractDural arteriovenous fistulas (DAVFs) located within superior sagittal sinus (SSS) wall with direct cortical venous drainage are rare. They are also known as variant DAVF (vDAVF) and form a special subgroup of DAVFs. Their chance of presenting with aggressive features is high compared with transverse sigmoid sinus fistula. They drain directly into cortical veins (Borden type 3, Cognard type III and IV). A systematic English literature review of SSS vDAVF was made. Systematic literature review revealed a total of 31 published cases. These were commonly seen in male population, (24 males, 77.41%, 24/31). Average age of patients was 54 years. A total of 24 patients (77.41%, 24/31) had aggressive clinical presentations with 13 patients (41.93%, 13/31) having intracranial hemorrhages (ICH). Two patients had rebleeding (15.38%, 2/13). Middle portion of SSS was commonly involved (15 cases, 75%). A total of 25 (96.15%, 25/26) cases had patent SSS. Most of the fistulas were idiopathic (65.38%, 17/26), with trauma being a frequent etiological factor (26.92%, 7/26). Venous ectasia was seen in 19 patients (59.37%, 19/32). Middle meningeal arterial (MMA) supply was seen in all patients (100%, 26/26), with bilateral MMA supply in 21 cases (80.76%), and unilateral in 5 cases (19.23%). Twenty patients (62.50%, 20/32) received only endovascular treatment (EVT), while four patients had EVT followed by surgery (12.5%, 4/32). Transarterial route via MMA was the preferred treatment option (79.16%). Complete obliteration of fistulas was noted in all cases (100%, 30/30). No immediate complication was noted after EVT. As much as 92.30% patients showed good recovery. Thus, SSS vDAVF forms a special subgroup of DAVF, with aggressive presentation, and warrants urgent treatment. EVT is effective treatment option and can produce complete obliteration.
Omental Solitary Fibrous Tumor: A Rare Tumor at Rare Site
Authors: Ingle Abhijeet , Reddy Surender , Reddy Vamshi Krishna 
Published: July 2021

AbstractExtrapleural solitary fibrous tumor-hemangiopericytoma is a rare tumor. We present a case of this tumor arising in omentum, which is an extremely rare site. The diagnosis was confirmed by diffuse expression of STAT6 on immunohistochemistry. The tumor was assigned a low-risk category according to recent risk categorization models. The patient was advised close follow-up as the tumor was excised completely. These tumors have the potential for recurrence and metastasis even after surgical excision. However, there are no definitive guidelines for adjuvant treatment due to lack of data.
A Comparative Evaluation of Antigen-Specific Sandwich Immunoassay and Indirect Immunofluorescence Assay (IIF) in Detecting Antineutrophil Cytoplasmic Antibodies: Are We Ready to Replace IIF with ELISA as the Primary Screening Method?
Authors: Deka Sangeeta , Kalita Deepjyoti , Shankar Ravi , Rekha U. Sasi , Sindhwani Girish 
Published: July 2021

Abstract
Background Antineutrophil cytoplasmic antibodies (ANCA) are important biomarkers in the diagnosis of ANCA-associated vasculitis, and indirect immunofluorescence (IIF) had been the method of choice for its detection from the very beginning. However, international consensus on ANCA testing (2017) advocates the use of high-quality immunoassays as the primary screening method. The purpose of this study was to evaluate the diagnostic performance of enzyme-linked immunosorbent assay (ELISA) compared to IIF in detecting ANCA.
Methods One-hundred eighty-nine serum samples of suspected or known cases of systemic vasculitis were screened for ANCA by IIF and proteinase-3- and myeloperoxidase-ELISA. In IIF, positive results were further divided into cytoplasmic pattern of ANCA and perinuclear pattern of ANCA, depending upon the pattern of fluorescence. McNemar’s chi-squared test was applied to check the equality of proportions of positive results, and Kappa statistics was used to measure the agreement between the two methods. Diagnostic performance of ELISA was evaluated taking IIF as reference.
Results IIF detected ANCA in 17.5% cases and ELISA detected it in 11.6% cases. A good agreement between the overall performance of ELISA and IIF was observed (K-value: 6.8, p-value: < 001). However, a significant difference in the proportion of positive results by the two methods was observed in McNemar’s test (two-sided p-value: 0.007). Taking IIF as standard, ELISA showed 60.6% sensitivity, 98.7% specificity, and predictive value of positive and negative results of 90.9 and 92.2%, respectively.
Conclusion The new generation antigen-specific ELISAs had high specificity but the chances of missing cases in primary screening due to the low sensitivity and high false negativity (39.4%) need to be dealt with.
1.1 Improving Radical Persistence through Confinement: A Survey
Authors: Bertrand M. P. , Besson E. , Gastaldi S. 
Published: July 2021

AbstractMost organic radical species are transient and were long considered to be beyond control. Tremendous progress in the knowledge and understanding of their reactivity has enabled their use as standard intermediates in organic synthesis. In this review, strategies implemented to increase radical lifetimes, without modifying fundamentally their structural features, are presented. A wide array of systems has been designed that allow modulation of the level of confinement constraints. The ability of these systems to increase radical lifetime has now reached the point where a transient radical can become persistent, which opens up many new prospects for future applications.
1.6 Sulfur-, Selenium-, and Silicon-Centered Radicals
Authors: Kaga A. , Yorimitsu H. 
Published: July 2021

AbstractSulfur-, selenium-, and silicon-centered radicals are versatile reaction intermediates in modern synthetic organic chemistry. These radicals are capable of adding to carbon–carbon multiple bonds such as alkene and arenes, thus introducing the corresponding elements into the products. These radicals can also serve as mediators of free-radical reactions, including as polarity-reversal catalysts, asymmetric catalysts, and halogen-atom abstraction agents, without these elements being incorporated into the products of the reactions. This chapter describes the utility of sulfur-, selenium-, and silicon-centered radicals in two sections. The first covers reactions involving incorporation of the corresponding elements into the products, while the second describes reactions using these radicals as catalysts or reagents to prepare products that do not contain the corresponding elements.