bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electroresponsive and spinnable hydrogels from xanthan gum and gelatin enhanced by Fe3+ ions coordination
Authors: Xu Qianru , Zhang Yaqi , Zhang Ruquan , Tao Yongzhen 
Published: September 2021

AbstractPolyelectrolyte hydrogels with spinnability and electroresponsive were prepared from xanthan gum (XG) and gelatin. Oscillatory rheological measurements were utilized to explore mechanical properties and thermal stability of the resultant XG‐Gelatin5 hydrogels. The XG‐Gelatin5 hydrogels possessed higher strength and larger critical strain than these of the XG hydrogels, demonstrating existence of synergistic interactions. The XG‐Gelatin5 hydrogels were stable in temperature range of 20–60°C, and gradually release drug with controlled manner in neutral and acid medium at 37°C. The self‐recoverable and thixotropic XG‐Gelatin5 hydrogels were extruded to form hydrogel fibers, and the dried hydrogel fibers rapidly bend towards cathode under applied voltage. Long hydrogel fibers were harvested with enhancement by Fe3+ ions, and were weaved and braided to obtain hydrogel fiber constructs. The XG‐Gelatin5 hydrogel fibers with electroresponsive and controlled drug release possess potential applications in biomaterials, tissue engineering, and drug carrier fields.
Synthesis and characteristics of poly(ethylene terephthalate) with EO‐PO‐EO triblock copolymers: A thermal and mechanical property study
Authors: Mao Hsu‐I , Hsu Te‐Sheng , Chen Chin‐Wen , Huang Kuan‐Wei , Rwei Syang‐Peng 
Published: September 2021

AbstractA series of multiblock copolymers poly(ethylene terephthalate)‐co‐poly(ethylene glycol)‐poly(propylene glycol)‐poly(ethylene glycol) (PET‐X%‐E‐P‐E) were synthesized from dimethyl terephthalate (DMT), ethylene glycol (EG) and poly(ethylene glycol)‐poly(propylene glycol)‐poly(ethylene glycol) (E‐P‐E) with a two‐step procedure via melt polymerization. The structure, composition, crystallization behavior, and thermal stability of the synthesized copolymers were determined by 1H‐NMR, FT‐IR, XRD, DSC, and TGA measurements. All samples exhibited good thermal stability at a Td‐5% above 300°C. DSC results revealed an increment trend of crystallization ability of copolymers in lower E‐P‐E content and then decreased when E‐P‐E concentration gradually raised to 40 wt%. Furthermore, the mechanical properties of copolymers were investigated systematically; the incorporation with E‐P‐E segments significantly enhanced the toughness and water absorption ability. Impact strength increased from 670.46 to 4448.75 J/m2, and water absorption values raised from 0.7% to 3.4% of the content of E‐P‐E increased. The stress–strain curve exhibited that tensile strength reduced from 40.38 to 17.88 MPa, the elongation at break increased from 4.6 to 27.9%. These new tough PET materials have an important application in toughness polyester fiber by the melt‐spinning techniques.
Synthesis and biological evaluation of 3,5‐diaryl‐pyrazole derivatives as potential antiprostate cancer agents
Authors: Anil Derya , Caykoylu Emine U. , Sanli Fatma , Gambacorta Nicola , Karatas Omer F. , Nicolotti Orazio , Algul Oztekin , Burmaoglu Serdar 
Published: September 2021

AbstractProstate cancer is the most frequently diagnosed tumor in men and the second leading cause of cancer‐associated mortality in most developed countries. 3,5‐Diaryl substituted pyrazole derivatives (20–28) were prepared starting from related chalcones and biologically evaluated for in vitro growth inhibition activity against PC3 and DU145 human prostate cancer cell lines. Compounds 23, 26, and 28 were found to be more potent as compared to the other halogen‐substituted derivatives. Especially, the 2‐bromo‐substituted pyrazole derivative (26) was found to be more potent against PC3 and DU145 cells. Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor 2 (VEGFR2) are known to be expressed in DU145 and PC3 cancer cells. The binding mode of the most selective compound 26 toward EGFR and VEGFR2 was investigated by employing docking simulations based on GLIDE standard precision (−5.912 and −6.949 kcal/mol, respectively).
2D Graphdiyne: A Rising Star on the Horizon of Energy Conversion
Authors: Wang Zhongqiang , Qi Lu , Zheng Zhiqiang , Xue Yurui , Li Yuliang 
Published: September 2021

AbstractTwo‐dimensional (2D) graphdiyne (GDY), a rapidly rising star on the horizon of carbon materials, is a new carbon allotrope featuring sp‐ and sp2‐cohybridized carbon atoms and 2D one‐atom‐thick network. Since the first successful synthesis of GDY by Professor Li's group in 2010, GDY has attached great interests from both scientific and industrial viewpoints based on its unique structure and physicochemical properties, which provides a fertile ground for applications in various fields including electrocatalysis, energy conversion, energy storage and optoelectronic devices. In this work, various potential properties of the GDY‐based electrocatalysts and their recent advances in energy conversion are reviewed, including atomic catalysts, heterogeneous catalysts, and metal‐free catalysts. The critical role of GDY in improving catalytic activity and stability is analyzed. The perspectives of the challenges and opportunities faced by GDY‐based materials for energy conversion are also outlined.
Improved results on state estimation for switched continuous‐time linear systems
Authors: Chen Yu , Wang Yue‐E , Wu Di 
Published: September 2021

AbstractThis paper investigates the state estimation problem for switched linear systems involving additive disturbance and measurement noise, whose modes need not to be cooperative. Under the assumption that there exist nonsingular matrices that transform the observer error system matrices into Metzler ones, by using multiple Lyapunov functions and average dwell time method, hybrid state observers, which can produce a framer covering all possible state trajectories, are designed in two cases, that is, all the subsystems are stable and some of the subsystems may be unstable. The constructed interval observer for the considered systems are hybrid dynamical systems and the initialized states of the upper and lower observers at each switching instants are coupled, since the transformation matrices for different subsystems are different. Compared with the robust observer design for switched systems with arbitrary switching sequences in the literature, the difficulty consists in proposing new observer design conditions related to the state reset at the switching instants for switched systems under average dwell time scheme. Finally, two examples are given to show the efficiency of the proposed approach.
A Bayesian longitudinal trend analysis of count data with Gaussian processes
Authors: VanSchalkwyk Samantha , Jeske Daniel R. , Kim Jane H. , Martins‐Green Manuela 
Published: September 2021

AbstractThe context of comparing two different groups of subjects that are measured repeatedly over time is considered. Our specific focus is on highly variable count data which have a nonnegligible frequency of zeros and have time trends that are difficult to characterize. These challenges are often present when analyzing bacteria or gene expression data sets. Traditional longitudinal data analysis methods, including generalized estimating equations, can be challenged by the features present in these types of data sets. We propose a Bayesian methodology that effectively confronts these challenges. A key feature of the methodology is the use of Gaussian processes to flexibly model the time trends. Inference procedures based on both sharp and interval null hypotheses are discussed, including for the important hypotheses that test for group differences at individual time points. The proposed methodology is illustrated with next‐generation sequencing (NGS) data sets corresponding to two different experimental conditions. In particular, the method is applied to a case study containing bacteria counts of mice with chronic and nonchronic wounds to identify potential wound‐healing probiotics. The methodology can be applied to similar NGS data sets comparing two groups of subjects.
Box–Behnken design avenue for development and validation of high‐performance thin‐layer chromatography method for estimation of rutin in Hemidesmus indicus
Authors: Shrivastava Suman , Daharwal Sanjay J. 
Published: September 2021

AbstractThe aim of this study was to determine the content of rutin in Hemidesmus indicus and to optimize the high‐performance thin‐layer chromatography method. The method was validated in compliance with the International Council for Harmonisation guidelines Q2 (R1) for parameters such as linearity, accuracy, precision, robustness, limit of detection, and limit of quantitation. A Box–Behnken design and response surface methodology has been used to investigate the impact of independent variables on the response. Three independent variables, mobile phase composition (% v/v), mobile phase volume (mL), and duration of saturation (min), were studied. Rutin was verified, and its content was determined using a validated high‐performance thin‐layer chromatography method with good linearity within the range of 200–1000 ng spot–1 with r2 = 0.9998 and correlation coefficient with calibration curve equation y = 0.0297x + 0.0001. The average percentage recovery values varied from 99.03 to 101.15 and 98.88 to 100.12%, respectively, for in‐house and marketed mother tincture). The peak area determination at three different concentration levels shows low values of percentage relative standard deviation (<2%) for inter‐day (0.04–0.06) and intra‐day (0.04–0.05) precision of rutin. The average content of rutin in extract and marketed mother tincture was 229 ± 0.57 and 210 ± 0.57 μg g–1. The proposed method was simple, precise, and accurate for the determination of rutin with frequent quality control assessment of H. indicus.
Recent advances in the chromatographic determination of the most commonly used anti‐hepatitis C drug sofosbuvir and its co‐administered drugs in human plasma
Authors: Abdel‐Tawab Muhammed Abdel‐Hamied , Abd El‐Moghny Muhammad G. , El Nashar Rasha Mohamed 
Published: September 2021

AbstractSofosbuvir is a direct‐acting antiviral drug that inhibits hepatitis C virus (HCV) NS5B polymerase, which in turn affects the virus replication inside biological systems. The clinical importance of sofosbuvir is based not only on its effect on HCV but also on other lethal viruses such as Zika and severe acute respiratory syndrome coronavirus disease 2019 (SARS‐COVID‐19). Accordingly, there is a continuous shedding of light on the development and validation of accurate and fast analytical methods for the determination of sofosbuvir in different environments. This work critically reviews the recent advances in chromatographic methods for the analysis of sofosbuvir and/or its metabolites in pure samples, pharmaceutical dosage forms, and in the presence of other co‐administered drugs to highlight the current status and future perspectives to enhance its determination in different matrixes.
Delving into brand anthropomorphisation strategies in the experiential context of name‐brand voice assistants
Authors: Vernuccio Maria , Patrizi Michela , Pastore Alberto 
Published: September 2021

AbstractConsumers' increasing use of voice‐activated artificial intelligence technologies is stimulating the development of a new line of research in the field of marketing aiming to analyse the branding implications in this innovative experiential context. The spread of so‐called name‐brand voice assistants (NBVAs) is creating interesting opportunities in terms of brand anthropomorphism. The brand anthropomorphisation strategies adopted by companies are poorly studied in the academic literature, and only one contribution has been made in the experiential field of NBVAs. Therefore, the objective of our work is to begin to fill this gap by investigating the pillars of brand anthropomorphisation strategies (i.e., activities and branding outcomes) in the specific NBVA context by adopting a managerial perspective. Therefore, we followed an exploratory qualitative approach based on in‐depth personal interviews with practitioners engaged in these strategies in the automotive sector. The resulting cognitive map reveals the following three levels of strategic pillars: drivers (i.e., designing a human‐like brand voice and human‐like consumer‐brand dialogue), intermediate outcomes (i.e., brand personality and the strength of consumer‐brand relationships), and final outcomes (i.e., multidimensional brand loyalty). Our study enriches both the literature concerning brand anthropomorphisation strategies and the nascent stream on NBVAs and provides managerial guidelines in the new in‐car NBVA context.
Influence of bearing coefficient in cold‐formed stainless steel bolted connection
Authors: Sobrinho Kelvin , da Silva André T. , Rodrigues Monique C. , Henriques José A. , Lima Luciano R. , da Vellasco Pedro C. G. 
Published: September 2021

AbstractThe connections play an important role in the overall behaviour of the structures. Therefore an adequate structural design taking into account both safe and economic criterion is necessary. The structural design of stainless steel bolted connections using actual codes can provide inadequate design capacity mainly due to the use of similar rules based on analogies from mild carbon structures. Thus, the purpose of this paper is to evaluate the structural response of stainless bolted connections considering the steel grade austenitic 304. Experimental and numerical analyses have been carried out considering bolted connection under bearing failure. In details, the study cases were subjected to two shear planes with thin‐plate and thick‐plate. In these cases, the occurrence of curling failures is possible. A detailed study involving the geometric parameters adopted by design equations of bolted stainless steel connections was made. The outcomes showed a reduction of the ultimate capacity characterised by out‐plane deformation. In addition, the current codes led to significant difference when compared to both experimental and numerical results.
Analysis of pallet rack beam members through a nonlinear GBT formulation with sectional constraints
Authors: Bonada Jordi , Casafont Miquel , Roure Francesc , Pastor Maria Magdalena 
Published: September 2021

AbstractThin‐walled open cross‐sections are commonly used in steel storage pallet rack structures. In some cases, open sections are employed as beam members. These beam members usually have weld spots along their length in order to reduce the distortional deformation under a flexural load. On the other hand, beam members are typically connected to columns by means of claws, which typically exhibit a nonlinear moment ‐ rotation relationship. These two characteristic should be taken into account in order to properly reproduce their structural response.In this paper, the Generalised Beam Theory (GBT) is used to perform a geometrical nonlinear analysis of a pallet rack beam members taking weld spots and the beam‐to‐column connection behavior into account. The influence of the number and location of weld spots, as well as the beam‐to‐column connection behavior, in the distortional deformation of a beam member is evaluated by means of GBT nonlinear analyses. The results show that the use of a small number of weld spots could be enough to minimize the beam distortional deformation. Moreover, the stiffness of the beam‐to‐column connection also has influence on the beam distortional deformation. Finally, GBT results are successfully compared with shell finite element analyses.
Design of Built‐up Nested Cold‐formed Steel Channel Compression Members
Authors: Vy Son Tung , Mahendran Mahen 
Published: September 2021

AbstractRecently, the use of built‐up cold‐formed steel (CFS) members in the form of nested channel (NC) compression members is becoming more popular in CFS construction. For NC compression members, the current CFS design standards have been shown to be inadequate, provide over‐conservative predictions, and include some cumbersome design rules relating to maximum allowable screw spacing and end fastener groups. New design guidelines have been proposed by some recent research studies, however, they are based on different assumptions and provide varying capacity predictions.This study has investigated (1) the design guidelines in the current design standards and past research studies, and (2) the effects of screw spacing as well as end fastener groups on the compression behaviour and capacity of NC members. It included a series of compression tests on short, intermediate and slender single channel and NC members, followed by developing validated finite element models and undertaking parametric studies. The results show that: (1) the compression capacity of NC members can be greater than twice that of their individual members, (2) the design rules on the maximum allowable screw spacing and end fastener groups are over‐conservative, and are mostly unnecessary, (3) the design rules in the current standards and past research studies are not suitable for predicting the compression capacities of the investigated NC members, and (4) proposed design guidelines based on the Direct Strength Method in the current CFS design standards can provide reliable predictions for the compression capacities of NC members.
Innovative shear transfer system for Concrete Filled Steel Tubes (CFST) in columns
Authors: Soltanalipour Milad , Ferrer Miquel , Albareda Albert , Marimon Frederic , Casafont Miquel , Iglesias Gorka 
Published: September 2021

AbstractThe common failure mode of composite steel‐concrete structural elements, such as composite columns, generally occurs due to the relative slipping or separation of the steel sheet and the concrete. This leads to materials overspending and low resistance. In the case of beam‐to‐column joints, the most common solution used in composite construction is introducing a perpendicular gusset plate, which is complex in terms of execution. On the other hand, there is no efficient solution for shear transferring along the whole length of the column to prevent slip under bending. The UPC patent improves very significantly the shear transferring between steel and concrete, enough to achieve the permanent connection in many cases, by means of generating a series of many crown‐shaped breakages produced by punching in the profiling stage, not only in the joints but also in the whole length. When the concrete sets, the said breakages embedded therein have the function of resisting shearing forces generated between both materials. It has been successfully applied to composite slabs and, in terms of composite columns, it is also a disruptive innovation to solve the current shear transfer limitation. Besides, this innovative system is easy to be massively produced avoiding the complexities of the conventional beam‐to‐column joints and reducing the construction costs, especially in high‐rise buildings. The aim of this paper is to present this new technology for connecting steel sheet and concrete in CFST columns.
Behavior of downstand simply supported steel‐concrete composite beam applying friction based demountable shear connection
Authors: Fodor Jovan , Schäfer Markus 
Published: September 2021

AbstractIn order to improve sustainability of composite structures and promote the principles of circular economy in construction industry, novel demountable shear connector based on the frictional behavior was developed within the framework of Work package 2 of parent project ECON4SD (Eco Construction for Sustainable Development) at the University of Luxembourg.The demountable composite floor system is composed out of modular concrete one‐way solid slabs with equidistantly embedded Halfen HTA‐CE rail channels, double symmetric steel I section and demountable connector device assembly based on HV high strength structural bolts for preloading that provides the demountable shear connection.In this paper trilinear behavior model is proposed for the force‐slip behavior of aforementioned connector device complying to the results of the push test experimental campaign and the results of FEA simulations. Afterwards, parametric study is performed on the range of simply supported composite beams in propped and unpropped condition under uniformly distributed load applying the aforementioned shear connection validating the predictability of the composite beam bending behavior in accordance with the rules of EN 1994‐1‐1.
Laser Cut passing‐through Open‐to‐CHS Beam‐to‐Column Connections
Authors: Das Rajarshi , Kanyilmaz Alper , Degee Herve 
Published: September 2021

AbstractAlthough Circular Hollow Sections (CHS) have always demonstrated their excellent properties in resisting high compression, tension as well as bending in all directions, thanks to their inherent shape and geometry, the existing open ‐to‐CHS connections used in the current industry (conventional connections) generally require a substantial amount of stiffeners or gusset plates due to their construction method i.e. direct welding or diaphragm connections. As a result, huge welding quantities are required which further complicates the fabrication procedure. Furthermore, due to a direct connection, the CHS column becomes prone to localized distortions. In order to minimize the aforementioned drawbacks, a “passing‐through” approach was proposed and investigated in the EU‐RFCS research project LASTEICON where connecting elements (i.e. one or more steel plates or a piece of I‐profile) pass through the CHS column through Laser Cut slots made in the column and the primary beams (namely the “main” I‐beams) are connected to both ends of the passing through elements (named as “through‐members”). The applied shear force, and if relevant the applied moment, is effectively transferred by the “through‐member” to the CHS column, whereas, the CHS column contributes significantly in resisting it through its large flexural and shear capacity. The present article summarizes the most interesting results obtained based on the experimentally validated numerical simulations for the different types of LASTEICON connections. Thanks to the superior fabrication quality and versatility offered by the laser cutting technology, different types of connection configurations were developed within the project. This article introduces a few of these possibilities: (1) Two‐way steel moment resisting connections, (2) Asymmetric steel connections, (3) Four‐way steel connections, and (4) Composite connections.