bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sobolev regularity solutions for a class of singular quasilinear ODEs
Authors: Zhao Xiaofeng , Li Hengyan , Yan Weiping 
Published: November 2021

AbstractThis paper considers an initial-boundary value problem for a class of singular quasilinear second-order ordinary differential equations with the constraint condition stemming from fluid mechanics. We prove that the existence of positive Sobolev regular solutions for this kind of singular quasilinear ODEs by means of a suitable Nash-Moser iteration scheme Meanwhile, asymptotic expansion of those positive solutions is shown.
Optimality of a Linear Decision Rule in Discrete Time AK Model
Authors: Shim Myungkyu 
Published: November 2021

Abstract
Surprisingly, formal proof on the optimality of a linear decision rule in the discrete time AK model with a CRRA utility function has not been established in the growth literature while that in the continuous time counterpart is well-established. This note fills such a gap: I provide a formal proof that consumption being linearly related to investment is a sufficient and necessary condition for Pareto optimality in the discrete time AK model.
Efficacy ofMajoon-e-Seer Alvi Khanin dyslipidemia: a single blind randomized standard controlled clinical trial
Authors: Quamri Mohd Aleemuddin , Wahab Adil , Alam Md Anzar , Ali Barkat Farooqui 
Published: November 2021

AbstractObjectivesMajoon-e-Seer Alvi Khan,a compound Unani formulation, has been indicated in disease conditions simulating dyslipidemia. The present study was done to substantiate the efficacy ofMajoon-e-Seer Alvi Khan(MSAK) in dyslipidaemia on scientific parameters.MethodsA randomized, single-blind, Standard controlled, clinical trial was carried out on 40 patients of dyslipidemia who were randomly allocated into test (n=30) and control (n=10) groups. The test drug, MSAK,and control drug, tablet Atorvastatin was given to the respective group for 60 days along with lifestyle modification.ResultsThe test drug significantly alleviated the symptoms of subjective parameters (p<0.05). There was a statistically significant reduction in lipid profile of the patients in the test group (p<0.05) than control drug treatment.ConclusionsThe study evidenced thatMajoon-e-Seer Alvi Khanis potentially effective and safe in the treatment of dyslipidemia. However, a multicentre study with a robust study design is required to generalize the results.
Evaluation of the need for pharmacogenomics testing among physicians in the West Bank of Palestine
Authors: Jarrar Yazun , Musleh Rami , Hamdan Anas , Ghanim Mustafa 
Published: November 2021

Abstract

Objectives
Pharmacogenomics (PGx) testing optimizes pharmacotherapy and reduces interindividual variation in drug responses. However, it is still not implemented in clinical practice in the West Bank of Palestine (WBP). The aim of this study was to determine the need for PGx education and testing among physicians from different specialties in WBP.

Methods
This study used a cross-sectional survey that was administered to 381 physicians from different cities in WBP. The questionnaire consisted of 27 closed-ended questions that evaluate the exposure and attitude toward PGx education, the role of PGx testing in clinical practice, and the capabilities of physicians in PGx testing.

Results
It was found that exposure to PGx education is low, with most of the respondents (81.1%) answering that PGx was not an integral part of their medical education. The majority (>90%) of the participants agreed that PGx should be included in the medical school curriculum. It was also found that 58.5% of the participants agreed that PGx testing is relevant to their current clinical practice. In addition, most of the participant physicians (>60%) think that they are currently not capable of prescribing and making decisions for pharmacotherapy based on PGx testing.

Conclusions
It is concluded that there is a high need for PGx education and implementation in clinical practice in WBP. We recommend adding PGx courses to the curricula of medical schools and going forward with the implementation of PGx testing in clinical practice in WBP.
Existence and uniqueness of positive solutions for fractional relaxation equation in terms of ψ-Caputo fractional derivative
Authors: Derbazi Choukri , Baitiche Zidane , Zada Akbar 
Published: November 2021

Abstract
This manuscript is committed to deal with the existence and uniqueness of positive solutions for fractional relaxation equation involving ψ-Caputo fractional derivative. The existence of solution is carried out with the help of Schauder’s fixed point theorem, while the uniqueness of the solution is obtained by applying the Banach contraction principle, along with Bielecki type norm. Moreover, two explicit monotone iterative sequences are constructed for the approximation of the extreme positive solutions to the proposed problem. Lastly, two examples are presented to support the obtained results.
Optical SNR estimation using machine learning
Authors: Rai Palash , Kaushik Rahul 
Published: November 2021

Abstract
A technique for the estimation of an optical signal-to-noise ratio (OSNR) using machine learning algorithms has been proposed. The algorithms are trained with parameters derived from eye-diagram via simulation in 10 Gb/s On-Off Keying (OOK) nonreturn-to-zero (NRZ) data signal. The performance of different machine learning (ML) techniques namely, multiple linear regression, random forest, and K-nearest neighbor (K-NN) for OSNR estimation in terms of mean square error and R-squared value has been compared. The proposed methods may be useful for intelligent signal analysis in a test instrument and to monitor optical performance.
The neonatal microbiome in utero and beyond: perinatal influences and long-term impacts
Authors: Hill Lee , Sharma Ruchika , Hart Lara , Popov Jelena , Moshkovich Michal , Pai Nikhil 
Published: November 2021

Abstract
The neonatal microbiome offers a valuable model for studying the origins of human health and disease. As the field of metagenomics expands, we also increase our understanding of early life influences on its development. In this review we will describe common techniques used to define and measure the microbiome. We will review in utero influences, normal perinatal development, and known risk factors for abnormal neonatal microbiome development. Finally, we will summarize current evidence that links early life microbial impacts on the development of chronic inflammatory diseases, obesity, and atopy.
Exploring digital interactivity: a multimodal and social semiotic approach to intersemiotic construction in COVID China website
Authors: Shi Dan 
Published: November 2021

Abstract
This paper explores intersemiotic construction and digital interactivity through a multimodal social semiotic lens examining the semiotic instantiations of interactive signs on the homepage of “Fighting COVID-19 the Chinese Way” (covid-19.chinadaily.com.cn), a website created to disseminate information on news and development of COVID prevention and control practices in China to contribute to global efforts to fight the pandemic. The study focuses on how digital interactivity is afforded by the COVID China website, where the interactive signs are ideationally and compositionally constructed for meaning representation and interpersonally for text-viewer relation construal. From the multimodal social semiotic perspective, systemic functional model-based cluster and intersemiotic analyses are applied to explore the visual, spatial, and linguistic features that contribute to the design and construction of interactive semiotic signs on the COVID China website and afford digital interactivity for viewers’ action potentials. This study extends the analytical focus to the semiotic instantiations of interactive signs and their intersemiotic construction process that stimulate the enabling of interactivity, instead of the interactivity per se, and demonstrates how different semiotic instantiations of interactive signs are featured and interact to afford digital interactivity. It argues for an integrated lens in analysis to look at the interactive signs not only as signs of action with action-enabling forms but also as signs of meanings that afford user-page interactivity.
Crystal structure of (4′E)-6′-(diethylamino)-2-[(E)-[(6-methylpyridin-2-yl)methylidene]amino]-4′-{2-[(2E)-1,3,3-trimethyl-2,3-dihydro-1H-indol-2-ylidene]ethylidene}-1′,2,2′,3,3′,4′-hexahydrospiro[isoindole-1,9′-xanthene]-3-one, C44H45N5O2
Authors: Li Kaihao , Wu Jinping , Lan Hairong , Wang Junmin , Yuan Juan 
Published: November 2021

Abstract
C44H45N5O2, triclinic

P

1
‾

$P\overline{1}$

(no. 2), a = 11.2140(4) Å, b = 11.9932(5) Å, c = 14.2703(5) Å, α = 98.879(3)°, β = 102.025(3)°, γ = 91.122(3)°, Z = 2, V = 1851.98(12) Å3, R

gt
(F) = 0.0549, wR
ref(F
2) = 0.1616, T = 293(2) K.
Quantum dots synthetization and future prospect applications
Authors: Mohamed Walied A. A. , Abd El-Gawad Hala , Mekkey Saleh , Galal Hoda , Handal Hala , Mousa Hanan , Labib Ammar 
Published: November 2021

Abstract
Quantum dots (QDs) are nanocrystals of a semiconductor material that exist in a size regime less than 10 nm. QDs have become promising nanoparticles for a wide variety of different applications. However, the major drawback of QDs is their potential toxicity. This review reports on some recent methods for the synthesis of QDs and explores their properties, structures, applications, and toxicity. QDs are extraordinary because their minute size produces a physically confined electron cloud, an effect known as the quantum confinement. Certainly, because of their special properties as they had a great unique optical, electronic, and chemical properties that were not observe in other materials. These unique properties of the QD are an attractive material for a variety of scientific and commercial applications, most of them recently been realized, such as biosensors, bioimaging, photodetectors, displays, solar cells, wastewater treatment, and quantum computers. Finally, but not the end, an interesting potential QD application in future perspectives will expect as light-emitting diode products, biomedical applications, and Li-Fi.
Behavioral Economics and Court Decision-Making
Authors: Teichman Doron , Zamir Eyal 
Published: November 2021

AbstractThe economic analysis of law assumes that court decisions are key to incentivizing people and maximizing social welfare. This article reviews the behavioral literature on court decision making, and highlights numerous heuristics and biases that impact judges and jurors and cause them to make decisions that diverge from the social optimum. In light of this review, the article analyzes some of the institutional features of the court system that may help minimize the costs of biased decisions in the courts.
Confidence limits for the averted infections ratio estimated via the counterfactual placebo incidence rate
Authors: Dunn David T. , Stirrup Oliver T. , Glidden David V. 
Published: November 2021

Abstract

Objectives
The averted infections ratio (AIR) is a novel measure for quantifying the preservation-of-effect in active-control non-inferiority clinical trials with a time-to-event outcome. In the main formulation, the AIR requires an estimate of the counterfactual placebo incidence rate. We describe two approaches for calculating confidence limits for the AIR given a point estimate of this parameter, a closed-form solution based on a Taylor series expansion (delta method) and an iterative method based on the profile-likelihood.

Methods
For each approach, exact coverage probabilities for the lower and upper confidence limits were computed over a grid of values of (1) the true value of the AIR (2) the expected number of counterfactual events (3) the effectiveness of the active-control treatment.

Results
Focussing on the lower confidence limit, which determines whether non-inferiority can be declared, the coverage achieved by the delta method is either less than or greater than the nominal coverage, depending on the true value of the AIR. In contrast, the coverage achieved by the profile-likelihood method is consistently accurate.

Conclusions
The profile-likelihood method is preferred because of better coverage properties, but the simpler delta method is valid when the experimental treatment is no less effective than the control treatment. A complementary Bayesian approach, which can be applied when the counterfactual incidence rate can be represented as a prior distribution, is also outlined.
An investigation of implicit bias about bending and lifting
Authors: Krug Roberto Costa , Silva Marcelo Faria , Lipp Ottmar V. , O’Sullivan Peter B. , Almeida Rosicler , Peroni Ian Sulzbacher , Caneiro J. P. 
Published: November 2021

Abstract

Objectives
Previous studies in a high-income country have demonstrated that people with and without low back pain (LBP) have an implicit bias that bending and lifting with a flexed lumbar spine is dangerous. These studies present two key limitations: use of a single group per study; people who recovered from back pain were not studied. Our aims were to evaluate: implicit biases between back posture and safety related to bending and lifting in people who are pain-free, have a history of LBP or have current LBP in a middle-income country, and to explore correlations between implicit and explicit measures within groups.

Methods
Exploratory cross-sectional study including 174 participants (63 pain-free, 57 with history of LBP and 54 with current LBP). Implicit biases between back posture and safety related to bending and lifting were assessed with the Implicit Association Test (IAT). Participants completed paper-based (Bending Safety Belief [BSB]) and online questionnaires (Tampa Scale of Kinesiophobia; Back Pain Attitudes Questionnaire).

Results
Participants displayed significant implicit bias between images of round-back bending and lifting and words representing “danger” (IATD-SCORE: Pain-free group: 0.56 (IQR=0.31–0.91; 95% CI [0.47, 0.68]); history of LBP group: 0.57 (IQR=0.34–0.84; 95% CI [0.47, 0.67]); current LBP group: 0.56 (IQR=0.24–0.80; 95% CI [0.39, 0.64])). Explicit measures revealed participants hold unhelpful beliefs about the back, perceiving round-back bending and lifting as dangerous (BSBthermometer: Pain-free group: 8 (IQR=7–10; 95% CI [7.5, 8.5]); history of LBP group: 8 (IQR=7–10; 95% CI [7.5, 9.0]); current LBP group: 8.5 (IQR=6.75–10; [7.5, 9.0])). There was no correlation between implicit and explicit measures within the groups.

Conclusions
In a middle-income country, people with and without LBP, and those who recovered from LBP have an implicit bias that round-back bending and lifting is dangerous.
Sustainable recovery of tourism in the post-COVID-19 world: Advocacy for a Resource Nexus perspective
Authors: Karthe Daniel , Reeh Tobias , Kempf Felix , Lee Halim , Guenther Edeltraud 
Published: November 2021

Abstract
The COVID-19 pandemic had unprecedented impacts on tourism worldwide, causing a major downturn in sectoral economic development and employment. Even though affected regions, businesses and customers are united in their hope of a rapid recovery, a return to business-as-usual is not desirable from an environmental perspective. The COVID-19 pandemic could, however, also be an opportunity for sustainability-oriented transformations in various segments of the tourist industry. A concept that has received growing attention in sustainability science and policy but that has not yet been applied to tourism may have a significant future potential here: the Resource Nexus. As a consistent and application-oriented framework for the integrated management of environmental resources, the Resource Nexus can be a model for advancing sustainability in tourism. Instead of looking at a single dimension only, the Resource Nexus considers environmental resources in a holistic way, including potential synergies and trade-offs between different development goals. This can ultimately support a transition not only to more sustainability, but also to greater resilience of the tourism sector against environmental changes.
Nachhaltigkeitseinstellungen entlang der Customer Journey: ein nachfrageseitiger Vergleich der DACH-Länder vor und während der Covid-19 Pandemie
Authors: Seeler Sabrina , Köchling Anne , Krüger Manon , Eisenstein Bernd 
Published: November 2021

Zusammenfassung
Wenngleich die Covid-19 Pandemie die globale Tourismusbranche vor enorme Herausforderungen stellt, wird sie auch als kritischer Wendepunkt hin zu mehr Nachhaltigkeit verstanden. Eine solche Transformation des Tourismus bedarf auch der Veränderungsbereitschaft der Reisenden sowie der Reduktion des Attitude-Behaviour-Gap. Dieser empirische Beitrag widmet sich der Fragestellung, wie sich Nachhaltigkeitseinstellungen der deutschen, österreichischen und schweizerischen Urlaubsreisenden im Vergleich darstellen und inwieweit diese sich von 2018 auf 2020 verändert haben. In den drei DACH-Ländern besteht eine gewisse Zurückhaltung bei Nachhaltigkeitsaspekten, die ein aktives persönliches Engagement erfordern. In der Schweiz ist die Bereitschaft, sich im Urlaub nachhaltig zu verhalten, am stärksten ausgeprägt. Im Zeitvergleich gibt es leicht positive Veränderungstendenzen über alle drei Quellmärkte. Somit liefert die Studie einen wichtigen Beitrag in der Nachhaltigkeitsdiskussion post-Covid-19.
Nonhormonal therapy for endometriosis based on energy metabolism regulation
Authors: Kobayashi Hiroshi , Shigetomi Hiroshi , Imanaka Shogo 
Published: November 2021

Ovarian function suppression is the current pharmacotherapy of endometriosis with limited benefit and adverse effects. New therapeutic strategies other than hormonal therapy are developed based on the molecular mechanisms involved in the hypoxic and oxidative stress environments and metabolism unique to endometriosis. A literature search was performed between January 2000 and March 2021 in the PubMed database using a combination of specific terms. Endometriosis-associated metabolic changes have been organized into four hallmarks: (1) glucose uptake, (2) aerobic glycolysis, (3) lactate production and accumulation, and (4) metabolic conversion from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis. Endometriotic cells favor glycolytic metabolism over mitochondrial OXPHOS to produce essential energy for cell survival. Hypoxia, a common feature of the endometriosis environment, is a key player in this metabolic conversion, which may lead to glucose transporter overexpression, pyruvate dehydrogenase kinase 1 (PDK1) and lactate dehydrogenase kinase A (LDHA) activation, and pyruvate dehydrogenase complex inactivation. Evading mitochondrial OXPHOS mitigates excessive generation of reactive oxygen species (ROS) that may trigger cell death. Therefore, the coinactivation of LDHA and PDK1 can induce the accumulation of mitochondrial ROS by converting energy metabolism to mitochondrial OXPHOS, causing endometriotic cell death. Metabolic pattern reconstruction in endometriotic lesions is a critical factor in cell survival and disease progression. One therapeutic strategy that may avoid hormone manipulation is focused on mitigating metabolic changes that have been detected in cells/tissues from women with endometriosis.

Lay summary
The most commonly used medical therapies for endometriosis have contraceptives and other side effects associated with hormone suppression and are therefore unsuitable for women desiring pregnancy. One therapeutic strategy that may avoid hormone manipulation is focused on changing metabolic profiles that have been detected in cells/tissues from women with endometriosis. Endometriotic cells favor glycolytic metabolism over mitochondrial oxidative phosphorylation (OXPHOS) to produce essential energy for cell growth. Furthermore, the metabolic conversion from mitochondrial OXPHOS to aerobic glycolysis suppresses cell death through the reduced generation of reactive oxygen species (ROS). This unique metabolic feature of endometriosis is important for cell survival and disease progression. Thus, changing the specific metabolic switch may increase mitochondrial ROS production, causing severe oxidative stress and cell death. This review describes new treatments by changing the metabolic profiles of endometriosis.
Jivi indigenous peoples: family functioning and health care, an analysis from Community Health Nursing practices
Authors: Medina-Maldonado Venus Elizabeth , Zerpa Yeigre , Torres-Torres Lydia , Navarro de Sáez María , Urgiles Patricia , Figueredo Henry 
Published: November 2021

Objective To explore the meaning of beliefs and practices related to family functioningand health care in a Venezuelan indigenous group.Materials and Methods A qualitative research study was conducted using a focused-ethnography (FE) method. The techniques implemented during data collection were focus group and observer-as-participant. Twenty-seven people distributed into four groups were included in the study. The qualitative content analysis method was selected for the interpretation stage.Results The most significant findings revealed that Jivi people’s customs were mixed with modern practices. Cultural practices such as maternity and childbirth are processes in which the formal healthcare system has a secondary role. Moreover, participants showed flexibility in terms of responsibilities without association to sex.Conclusion Training of human resources with an intercultural approach is a measure that could strengthen the practices of ethnic groups in terms of healthcare.
Photodegradation and kinetics of edible oil refinery wastewater using titanium dioxide
Authors: Aisien Eki T. , Aisien Felix A. 
Published: November 2021

Edible oil refinery wastewater (EORW) is one source of environmental pollution in Nigeria. The treatment of EORW before discharge into the environment remains a significant challenge in the edible oil refinery industries. This research was aimed at photocatalytic treatment of EORW using a batch photocatalytic reactor with titanium dioxide photocatalyst. We investigated the physicochemical parameters: chemical oxygen demand (COD), biological oxygen demand (BOD5), oil and grease, phenol, chloride (Cl-), total suspended solids, sulfate (SO42-), and phosphate (PO43-) using American Public Health Association methods. The results showed that the reduction efficiency of the treated EORW with TiO2 catalyst ranged between 65.8% (PO43-) and 87.0% (COD), and the improvement in efficiency was 54.1% (pH) and 60.8% dissolved oxygen. However, the results showed no significant difference (p<0.05) in the control treatment without catalyst. The biodegradability of EORW increased from 0.196 to 0.32. It was observed that the optimum values were an initial EORW concentration of 100 mL/L, irradiation time of 90min, catalyst dose of 1.25 g/L, and an agitation speed of 900 rpm. The kinetics of the photodegradation process was well described by the pseudo-first-order equation (R2>0.96) and pseudo-second-order equation (R2>0.98). The intra-particle diffusion model fairly represented the diffusion mechanism with an R2 value of 0.806. The treated EORW met the most acceptable water quality standards for discharged effluent according to the maximum permissible limits of the Nigerian National Environmental Standards and Regulations Enforcement Agency.Significance:

Photocatalytic treatment of EORW gave negligible results in the absence of a photocatalyst.
The photocatalytic degradation of EORW improved its biodegradability.
Photocatalytic treatment of EORW significantly reduced the pollutants in the wastewater.
The pseudo-first-order equation (R2>0.96)