bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large Particle Separation From Non-Newtonian Slurries Using Bump Arrays
Authors: Pease Leonard F. , Bamberger Judith Ann , Burns Carolyn A. , Minette Michael J. 
Published: October 2021

Abstract
Here we evaluate the performance of bump arrays to separate large particles from non-Newtonian slurries with Bingham and Cross rheology. Bump arrays in deterministic lateral displacement devices separate large particles from small particles using arrays of staggered posts. Large particles, defined as those with radii larger than the distance between the edge of a post and the stagnation streamline from the next downstream post, must bump toward one side of the device, whereas particles smaller than this distance slalom from entrance to exit without net lateral displacement. Although these devices have been used to separate a wide variety of large particles from blood cells to sand, partition of large particles from non-Newtonian fluids remains unexplored. Yet, an important set of modestly concentrated slurries, including Hanford nuclear waste, displays non-Newtonian rheology. Here we evaluate the influence of non-Newtonian rheology on the large-small particle size cutoff in bump arrays using a model that explores the influence of yield stresses, ratios of zero and infinite shear viscosities, and Cross’s exponent under strictly laminar well-developed conditions. Surprisingly, we find that viscosity ratios and Cross’s exponent make no significant difference on the particle cutoffs between large particles that bump and small particles that slalom around the posts from entrance to exit. In contrast, we find that yield stresses do significantly affect the size cutoff. As the yield stress increases, velocity profiles become more plug like lowering the size cutoff. For nuclear waste separations where removing large particles is a priority, increasing yield stresses is conservative.
An Experimental Study on the Effects of Burst Pressure on Air Blast Development in a Blast Wave Simulator
Authors: Zieg Parker , Benson John , Liu Yang 
Published: October 2021

Abstract
Due to the extensive use of explosive devices in military conflicts, there has been a dramatic increase in life-threatening injuries and resultant death toll caused by explosive blasts. In an attempt to better understand the blast waves and mitigate the damages caused by such blast waves, various devices/systems have been developed to replicate the field blast scenarios in laboratory conditions. The East Carolina University Advanced Blast Wave Simulator (i.e., ECU-ABWS) is one such facility that can reproduce blast waves of various shapes and profiles. The peak overpressure of a blast is the key factor that causes the greatest number of damages, and it is essentially determined by the burst pressure of the blast. Therefore, a better understanding of the effects of burst pressure on blast generation and development is strongly desired to develop safer and more effective blast mitigation technologies. In the present study, a series of experiments were carried out in the ECU-ABWS to characterize the blast waves generated under different burst pressure conditions. While the incident (side-on) pressures at multiple locations along the blast propagation direction were measured using a temporally-resolved multi-point pressure sensing system, the time-evolutions of blast wave profiles were also qualitatively revealed by using a high-speed Schlieren imaging system. The synchronization of pressure sensing and Schlieren image acquisition enables us to extract more physical details of the dynamic blast wave development under different burst pressure conditions by associating the incident pressures and shock wave morphologies. In this study, the different burst pressures were achieved by altering the thickness of the membrane separating the driver section of pressurized gas and the driven section of air at atmospheric pressure. It is found that there is a linear relationship between the burst pressure and the peak overpressure. As the burst pressure increases (by increasing the membrane thickness), more clearly defined shock wavefronts are also observed along with the peak overpressure increase.
Viability of OpenFOAM as the Numerical Engine for Augmented Reality Sandbox
Authors: Smith Elizabeth 
Published: October 2021

Abstract
Many augmented reality sandboxes use a single purpose implementation of standard numerical schemes to solve the Saint-Venant equations for shallow water in real time. This work evaluates the open-source computational fluid dynamics (CFD) package OpenFOAM as an alternative to the custom implementations traditionally used. Many sandboxes are used in educational and research settings and CFD engines with costly licensing was not desirable. The goal of this work is to identify or create an OpenFOAM solver that handles features such as dry conditions and complex topographies. The existing shallowWaterFoam solver was identified as the best candidate but required modification to handle scenarios representative of the target application. Replacing the existing custom numerical algorithm with the OpenFOAM software will more easily allow future incorporation additional phenomena.
Numerical Study on a Flow Field in the Rinsing Process of a Beverage Can Transported With a Constant Velocity
Authors: Kawachi Tatsuma , Sasaki Takuto , Kaneko Aya , Nishio Yu , Ogawa Takanobu 
Published: October 2021

Abstract
The present study investigates the flow field in a rinsing process of a beverage can numerically and experimentally. The three-dimensional Navier-Stokes equations are solved with a finite volume method along with the volume of fluid (VOF) method for free surface. The beverage can set upside down is transported with a constant velocity and rinsed with a water jet ejected from a nozzle below the can. The case of a can at rest is also simulated. The result shows that the ejected water impinges on the can bottom and spreads along the side surface of the can. Then, as it flows down toward the can mouth, its front surface forms splashes. For the stationary can case, after the jet impinges on the can bottom, it almost evenly spreads over the side surface. The water flows downward and becomes branched flows by fingering. The time average of VOF is calculated to visualize the regions rinsed by water. For the case of a moving can, only the top region of the can is rinsed, and the ratio of the rinsed region drops to 29% from 69% for the stationary case. The computed water surfaces qualitatively agree with the experimental result, but the shape of the front surface, such as splashes and fingerings, cannot be resolved with the simulation.
A Single-Camera Synthetic Schlieren Method for Measuring Two-Dimensional Liquid Surfaces
Authors: Xu Duo , Li Huixin , Avila Marc 
Published: October 2021

Abstract
A single-camera synthetic Schlieren method is introduced here to measure two-dimensional topography and depth of dynamic free liquid surfaces. The method is simple and easy to implement. Because of light refraction (following Snell’s law), markers on a flat bottom which are seen through the surfaces of a transparent liquid are virtually displaced. This leads to a governing equation that the liquid surface depth (and its topography) is associated with the marker displacement. In the equation, the refractive index of the liquid (e.g. water) can be obtained by a refractometer (or from a technical reference), and the displacements of the markers can be obtained by a cross-correlation method which is usually used in particle image velocimetry. In the equation, the only unknown, the depth of the surface, can be obtained by solving the governing equation with boundary conditions. Unlike free-surface synthetic Schlieren (FS-SS) of Moisy et al. (Exp. Fluids, 1021, 46, 2009), our method does not require a reference depth (which is obtained before or after experiments), so that flows with temporally evolving depth can be measured. Experiments of liquid ripples and dam-break flows were performed to test the method. The results agree well with those obtained with FS-SS and visualization measurements.
Can Bump Arrays Separate Particles From Turbulent Flows?
Authors: Pease Leonard F. , Serkowski Jason , Veldman Timothy G. , Willams Jonathan , Yu Xiao-Ying , Minette Michael J. , Bamberger Judith Ann , Burns Carolyn A. 
Published: October 2021

Abstract
In this paper, we evaluate the hypothesis that bump arrays can be used to separate particles from turbulent flows entering the array. Microfluidic bump arrays are known for separating particles by size from laminar inlet flows. However, turbulent inlet flows have not been explored but become important as microfluidic bump arrays are scaled up to mesofluidic bump arrays. We find experimentally that particle separation is indeed effective at higher Reynolds numbers. These experimental findings portend industrial scale particle separation due to the higher flow rates they facilitate.
Magnetostratigraphy and magnetic properties of the Jurassic to Lower Cretaceous Girón Group (northern Andes, Colombia)
Authors: Jiménez Giovanny , García-Delgado Helbert , Geissman John W. 
Published: October 2021

AbstractWe report paleomagnetic results from the Jurassic to Lower Cretaceous continental sedimentary succession exposed in the eastern limb of the Los Yariguíes anticlinorium, Eastern Cordillera, Colombia. About 820 m of a stratigraphic section of the upper part of the Girón Group (Angostura del Río Lebrija and Los Santos Formations) was sampled to construct a magnetic polarity stratigraphy. A total of 199 independent samples that yield interpretable and acceptable data have a characteristic remanent magnetization component (ChRM) isolated between 400 °C and 680 °C in progressive thermal demagnetization. Demagnetization behavior and rock magnetic properties are interpreted to indicate that hematite is the principal magnetization carrier with a possible contribution by magnetite in some parts of the section. After tilt correction, 123 samples are of normal polarity (declination [D] = 44.9°, inclination [I] = +9.7°, R = 110.64, k = 9.87, and α95 = 4.3°), and the other 76 accepted samples are of reverse polarity (D = 216.4°, I = −6.1°, R = 68.29, k = 9.72, and α95 = 5.5°). The statistical reversal test conducted on virtual geomagnetic poles is positive (class B). Based on paleontologic age estimates for the Cumbre and Rosablanca Formations, we assume a Berriasian age for the Los Santos Formation. The magnetostratigraphic data from the Girón Group strata are interpreted to suggest an age for the sampled part of the section between early Kimmeridgian and early Valanginian (ca. 157–139 Ma). The age of the Angostura del Río Lebrija Formation is estimated as between early Kimmeridgian and early Tithonian (ca. 157–146.5 Ma). The age of the Los Santos Formation is estimated between early Tithonian and early Valanginian (146.5–139.3 Ma). With our proposed, but nonunique, correlation with the Geomagnetic Polarity Time Scale, the Jurassic-Cretaceous boundary is interpreted to be located within the Los Santos Formation. The Girón Group is characterized by two periods of high (&gt;8 cm/k.y.) and two periods of low (&lt; 2 cm/k.y.) sedimentation rates. An inferred clockwise rotation of ∼44°, based on paleomagnetic declination data from the Girón Group, is similar to rotation estimates reported in some previous studies in the general area, and this facet of deformation could be related to local and regional response to displacement along regional-scale strike-slip faults.
Disruption in essential health services in Mexico during COVID-19: an interrupted time series analysis of health information system data
Authors: Doubova Svetlana V , Leslie Hannah H , Kruk Margaret E , Pérez-Cuevas Ricardo , Arsenault Catherine 
Published: October 2021

IntroductionThe COVID-19 pandemic has disrupted health systems around the world. The objectives of this study are to estimate the overall effect of the pandemic on essential health service use and outcomes in Mexico, describe observed and predicted trends in services over 24 months, and to estimate the number of visits lost through December 2020.MethodsWe used health information system data for January 2019 to December 2020 from the Mexican Institute of Social Security (IMSS), which provides health services for more than half of Mexico’s population—65 million people. Our analysis includes nine indicators of service use and three outcome indicators for reproductive, maternal and child health and non-communicable disease services. We used an interrupted time series design and linear generalised estimating equation models to estimate the change in service use and outcomes from April to December 2020. Estimates were expressed using average marginal effects on the risk ratio scale.ResultsThe study found that across nine health services, an estimated 8.74 million patient visits were lost in Mexico. This included a decline of over two thirds for breast and cervical cancer screenings (79% and 68%, respectively), over half for sick child visits and female contraceptive services, approximately one-third for childhood vaccinations, diabetes, hypertension and antenatal care consultations, and a decline of 10% for deliveries performed at IMSS. In terms of patient outcomes, the proportion of patients with diabetes and hypertension with controlled conditions declined by 22% and 17%, respectively. Caesarean section rate did not change.ConclusionSignificant disruptions in health services show that the pandemic has strained the resilience of the Mexican health system and calls for urgent efforts to resume essential services and plan for catching up on missed preventive care even as the COVID-19 crisis continues in Mexico.
Cardiological Disease in the Armed Forces: A Clear and Present Danger
Authors: Fisher Nicholas G. , Nicol Edward D. 
Published: October 2021

AbstractDespite a younger cohort of individuals than typically found in other large organisations the Armed Forces are not free from cardiac disease. Indeed some conditions are more frequently found and the high risk occupations of individuals within the Armed Forces makes it imperative that all cardiac conditions are identified rapidly and correctly. By illustrating actual cases, we highlight the need for service personnel to have rapid access to expert cardiological expertise, from individuals with an in depth occupational knowledge of the Armed Forces, 365 days per year.
Patients’ Perception of Military Doctors in Fracture Clinics - does the Wearing of Uniform Make a Difference?
Authors: McLean Christopher , Patel Pareeta , Sullivan Carl , Thomas Mark 
Published: October 2021

AbstractWe performed a study during our Trauma Week when patients who were referred from the accident department with fractures were reviewed in our fracture clinic. During our Trauma Week, Mister Thomas, Consultant Orthopaedic and Trauma Surgeon or Surgeon Lieutenant Commander McLean, Specialist Registrar in Orthopaedic and Trauma Surgery reviewed a total of 93 patients in fracture clinic. All patients were given an anonymous questionnaire regarding their perceptions of their attending clinician, 77 were completed. Forty-nine questionnaires regarding Surgeon Lieutenant Commander McLean and 28 regarding Mister Thomas were available for analysis. During the Trauma Week all patients were seen in the same location in identical cubicles by either of the two clinicians, consultations were typically brief lasting about five minutes. Throughout the week the clinicians, one military and one civilian, wore differing attire. The military uniform comprised Royal Navy number four action working dress. The civilian attire comprised ‘dog-robbers’ (jacket, shirt with tie and smart trousers). The hypothesis tested was that the use of military uniform might alter patients’ perceptions of their attending clinician. Our results appear to demonstrate that the attire of the attending clinician does not adversely influence patients’ perceptions of their attending clinician.
Dose–response functions and surrogate models for exploring social contagion in the Copenhagen Networks Study
Authors: Donges Jonathan F. , Lochner Jakob H. , Kitzmann Niklas H. , Heitzig Jobst , Lehmann Sune , Wiedermann Marc , Vollmer Jürgen 
Published: October 2021

AbstractSpreading dynamics and complex contagion processes on networks are important mechanisms underlying the emergence of critical transitions, tipping points and other non-linear phenomena in complex human and natural systems. Increasing amounts of temporal network data are now becoming available to study such spreading processes of behaviours, opinions, ideas, diseases and innovations to test hypotheses regarding their specific properties. To this end, we here present a methodology based on dose–response functions and hypothesis testing using surrogate data models that randomise most aspects of the empirical data while conserving certain structures relevant to contagion, group or homophily dynamics. We demonstrate this methodology for synthetic temporal network data of spreading processes generated by the adaptive voter model. Furthermore, we apply it to empirical temporal network data from the Copenhagen Networks Study. This data set provides a physically-close-contact network between several hundreds of university students participating in the study over the course of 3 months. We study the potential spreading dynamics of the health-related behaviour “regularly going to the fitness studio” on this network. Based on a hierarchy of surrogate data models, we find that our method neither provides significant evidence for an influence of a dose–response-type network spreading process in this data set, nor significant evidence for homophily. The empirical dynamics in exercise behaviour are likely better described by individual features such as the disposition towards the behaviour, and the persistence to maintain it, as well as external influences affecting the whole group, and the non-trivial network structure. The proposed methodology is generic and promising also for applications to other temporal network data sets and traits of interest.
The Changshagou gold deposit, Eastern Tianshan, NW China: orogenic gold mineralization overprinting a porphyry gold occurrence
Authors: Liu Yihao , Zhao Yun , Xue Chunji , Yu Liang , Chu Haixia , Zhao Xiaobo 
Published: October 2021

Abstract

The temporal–spatial relationships of porphyry and orogenic gold mineralization in the Eastern Tianshan Orogenic Belt are ambiguous. The newly discovered Changshagou deposit in this belt contains both porphyry and orogenic gold mineralization, which are characterized by polymetallic–sulfide veinlets and quartz–pyrite veins, respectively. Fluid inclusions in the porphyry mineralization episode were trapped at 290–340°C with salinities of 3.0–8.0 wt% NaCl
equiv
. The homogenization temperatures and salinities in the orogenic mineralization episode range from 240 to 300°C and from 1.0 to 5.0 wt% NaCl
equiv
. Coexisting V- and L-type fluid inclusions with similar homogenization temperatures are indicative of fluid immiscibility. The
δ
18
O
w
and
δ
D
w
values are in the ranges 7.6–9.1 and −70.9 to −84.0‰ in the porphyry mineralization episode, and 6.4–7.1 and −65.7 to −72.1‰ in the orogenic mineralization episode, overlapping magmatic and metamorphic ranges, respectively. The pyrite
δ
34
S values range from 3.5 to 4.9‰, falling into the magmatic range. Pyrite in porphyry and orogenic mineralization episodes yield Re–Os isotope ages of 269.1 ± 2.9 and 257.4 ± 2.4 Ma. The porphyry and orogenic gold mineralizations are genetically associated with the quartz syenite porphyry and Kanggur strike-slip shear activity, respectively.
Hypozonal gold mineralization in shear zone-hosted deposits driven by fault valve action and fluid mixing: the Nalunaq deposit, Greenland
Authors: Smith Martin , Banks David , Ray Santanu , Bowers Francis 
Published: October 2021

Abstract

The Nalunaq deposit, Greenland, is a hypozonal, shear zone-hosted, Au deposit. The shear zone has previously been interpreted as having undergone four stages of deformation, accompanied by fluid flow and vein formation. Coupled with previous trapping
T
estimates, fluid inclusion data are consistent with the trapping of fluids with salinities between 28 and 45 wt% NaCl equiv., from 300 to 475°C during D
2
and D
3
, with pressure varying between
c.
800 and 100 MPa. The range reflects pressure cycling during seismic slip-related depressurization events. D
4
fluids were lower salinity and trapped from 200 to 300°C, at
c.
50–200 MPa during late-stage normal faulting. The variation in major element chemistry is consistent with the ingress of hypersaline, granitoid equilibrated fluids into the shear zone system and mixing with fluids that had reacted with the host metamorphic rocks. D
4
-stage fluids represent the ingress of meteoric fluids into the system. Gold contents in inclusion fluids range from
c.
300 to 10 mg kg
−1
. These data are consistent with the high-
P–T
solubility of Au as AuHS(H
2
S)
3
0
complexes, and Au deposition by decompression and cooling. The high salinities also suggest Au transport as chloride complexes may have been possible. Gold distribution was modified by the release of chemically bound or nanoscale Au during sulfide oxidation at the D
4
stage.
Cancer Signaling Drives Cancer Metabolism: AKT and the Warburg Effect
Authors: Hosios Aaron M. , Manning Brendan D. 
Published: October 2021

Abstract
The Warburg effect, the propensity of some cells to metabolize glucose to lactate in the presence of oxygen (also known as aerobic glycolysis), has long been observed in cancer and other contexts of cell proliferation, but only in the past two decades have significant gains been made in understanding how and why this metabolic transformation occurs. In 2004, Cancer Research published a study by Elstrom and colleagues that provided one of the first connections between a specific oncogene and aerobic glycolysis. Studying hematopoietic and glioblastoma cell lines, they demonstrated that constitutive activation of AKT promotes an increased glycolytic rate without altering proliferation or oxygen consumption in culture. They proposed that it is this effect that allows constitutive AKT activation to transform cells and found that it sensitizes cells to glucose deprivation. In the years since, mechanistic understanding of oncogenic control of metabolism, and glycolysis specifically, has deepened substantially. Current work seeks to understand the benefits and liabilities associated with glycolytic metabolism and to identify inhibitors that might be of clinical benefit to target glycolytic cancer cells.
See related article by Elstrom and colleagues, Cancer Res 2004;64:3892–9
A Novel Long Noncoding RNA Finetunes the DNA Damage Response in Hepatocellular Carcinoma
Authors: Barcena-Varela Marina , Lujambio Amaia 
Published: October 2021

Abstract
The study by Unfried and colleagues reports the intriguing discovery of a novel long noncoding RNA (lncRNA) with a critical role in the regulation of DNA damage response in hepatocellular carcinoma. Providing an exhaustive and detailed characterization of the complex network interactions within the double-stranded breaks in the DNA, the authors demonstrated that NIHCOLE serves as a scaffold and facilitator of nonhomologous end-joining machinery. This study greatly contributes to the growing evidence supporting the key roles of ncRNAs in health and disease. Although larger studies are needed to understand the potential of lncRNAs to improve the clinical management of patients with cancer, this study demonstrates that high expression of NIHCOLE may be associated with an impaired response to DNA damage–based therapies, in part through its role in preventing cell death.
See related article by Unfried et al., p. 4910