bluuebunny/crossref_metadata_2025_split huggingface dataset:
Verification of the eighth edition of the UICC‐TNM classification on surgically resected lung adenocarcinoma: Comparison with previous classification in a local center
Authors: Minato Hiroshi , Katayanagi Kazuyoshi , Kurumaya Hiroshi , Tanaka Nobuhiro , Fujimori Hideki , Tsunezuka Yoshio , Kobayashi Takeshi 
Published: June 2021

AbstractBackgroundThe UICC 8th TNM classification of lung cancer has been changed dramatically, especially in measuring methods of T‐desriptors. Different from squamous‐ or small‐cell carcinomas, in which the solid‐ and the invasive‐diameter mostly agree with each other, the diameter of the radiological solid part and that of pathological invasive part in adenocarcinomas often does not match.AimWe aimed to determine radiological and pathological tumor diameters of pulmonary adenocarcinomas with clinicopathological factors and evaluate the validity of the 8th edition in comparison with the 7th edition.Methods and ResultsWe retrospectively analyzed clinicopathological factors of 429 patients with surgically resected pulmonary adenocarcinomas. The maximum tumor and their solid‐part diameters were measured using thin‐sectioned computed tomography and compared with pathological tumor and invasive diameters. Overall survival (OS) rate was determined using the Kaplan–Meier method for different subgroups of clinicopathological factors. Akaike's information criteria (AIC) was used as a discriminative measure for the univariate Cox model for the 7th and 8th editions. Multivariate Cox regression analysis was performed to explore independent prognostic factors. Correlation coefficients between radiological and pathological diameters in the 7th and 8th editions were 0.911 and 0.888, respectively, without a significant difference. The major reasons for the difference in the 8th edition were the presence of intratumoral fibrosis and papillary growth pattern. The weighted kappa coefficients in the 8th edition were superior those in the 7th edition for both the T and Stage classifications. In the univariate Cox model, AIC levels were the lowest in the 8th edition. Multivariate analysis revealed that age, lymphovascular invasion, pT(8th), and stage were the most important determinants for OS.ConclusionThe UICC 8th edition is a more discriminative classification than the 7th edition. For subsolid nodules, continuous efforts are necessary to increase the universality of the measurement of solid and invasive diameters.
Dysmorphic and illness anxiety‐related unwanted intrusive thoughts in individuals with obsessive–compulsive disorder
Authors: Pascual‐Vera Belén , Belloch Amparo 
Published: June 2021

AbstractBackground/ObjectiveUnwanted intrusive thoughts (UITs) are considered normal variants of the obsessions found in obsessive–compulsive disorder (OCD). Similarly, intrusive and persistent preoccupations about appearance defects in body dysmorphic disorder (BDD) and images and thoughts about illness in illness anxiety disorder (IAD) are abnormal variants of the thoughts and concerns about appearance and health found in non‐clinical individuals. This study examines whether patients with OCD have frequent and distressing UITs with contents related to BDD and IAD, in addition to OCD‐related UITs.MethodThirty‐nine participants with OCD (Mage = 32.45, standard deviation [SD] = 11.57; 63% men) completed the Questionnaire of Unpleasant Intrusive Thoughts (QUIT), designed to assess obsessional, dysmorphic and illness anxiety UITs and their associated functional consequences (emotions, appraisals, and neutralizing or control strategies).ResultsUp to 71% of the individuals with OCD experienced the three UIT modalities. As expected, OCD‐related UITs were the most frequent, although were no differences among the three UIT contents in terms of the disturbance they caused. The OCD intrusions were the most interfering, egodystonic and dysfunctionally appraised, and they instigated more neutralizing behaviours. Nonetheless, all UITs instigate the need to do something to alleviate the discomfort caused by their intrusion and attempts to suppress them.ConclusionUITs with different contents not always related to typical obsessive themes are a common experience in patients with OCD. These UITs could have detrimental consequences for the course of the disorder itself, and they should be adequately addressed in both the assessment and treatment of these patients.
Pathways to and factors associated with rape stigma experienced by rape survivors in South Africa: Analysis of baseline data from a rape cohort
Authors: Jewkes Rachel , Mhlongo Shibe , Chirwa Esnat , Seedat Soraya , Myers Bronwyn , Peer Nasheeta , Garcia‐Moreno Claudia , Dunkle Kristin , Abrahams Naeemah 
Published: June 2021

AbstractRape stigma, both external and self‐stigmatization (self‐blame), is associated with adverse health outcomes. Understanding its origins and resilience factors is critical for reducing and preventing it. We describe the prevalence of rape stigma, the characteristics of women experiencing it and the pathways to experiencing greater stigma. The Rape Impact Cohort Evaluation study enrolled 852 women aged 16–40 years who had been raped from post‐rape care centres in Durban, South Africa. We present a descriptive analysis of the baseline data, a multinomial logistic regression model of factors associated with different levels of stigma and a structural equation model (SEM). Most women reported stigmatizing thoughts or experiences, with self‐stigmatizing thoughts being more prevalent than external stigmatization. The multinomial model showed that experiences of childhood or other trauma, emotional intimate partner violence (IPV), having less gender equitable attitudes and food insecurity were significantly associated with medium or high versus low levels of stigma. Internal and external stigma were significantly associated with each other. Women who had been previously raped reported less stigma. The SEM showed a direct path between food insecurity and rape stigma, with poorer women experiencing more stigma. Indirect paths were mediated by more traditional gender attitudes and childhood trauma experience and other trauma exposure. Our findings confirm the intersectionality of rape stigma, with its structural drivers of food insecurity and gender inequality, as well as its strong association with prior trauma exposure. Rape survivors may benefit from gender‐empowering psychological support that addresses blame and shame.
In Vivo Cigarette Smoke Exposure to Examine the Expression of Genes Involved in the Inflammatory Response in the Mouse Uterus
Authors: Budani Maria Cristina , Carletti Erminia , Tiboni Gian Mario 
Published: June 2021

AbstractCigarette smoke may impair uterine function, but the underlying mechanisms are poorly characterized. In this article, we describe the methodology for whole‐body exposure to cigarette smoke together with assessment of the impact of this exposure on the expression of a panel of genes related to stress and toxicity pathways in mouse uteri using an in vivo model. C57BL/6 mice are whole‐body‐exposed to three cigarettes daily, 7 days/week, for 2 months using a specific rodent ventilator. Uteri are then collected and subjected to qRT‐PCR analysis using the Stress & Toxicity PathwayFinder RT2 Profiler PCR Array (Qiagen). Cigarette smoke was found to be associated with an upregulation (≥2‐fold) of C‐reactive protein (Crp; 2.65‐fold, p‐value = 0.02), growth arrest and DNA‐damage‐inducible45γ (Gadd45γ; 2.11‐fold, p‐value = 0.04), interferon γ (Ifnγ; 2.05‐fold, p‐value = 0.01), and interleukin1α (Il1α; 7.74‐fold, p‐value = 0.003) and downregulation of matrix metallopeptidase‐9 (Mmp9; −2.42‐fold, p‐value = 0.01). The protocol used in this study may represent a new experimental model of mouse in vivo mainstream exposure to cigarette smoke. In addition, the resulting overexpression of pro‐inflammatory cytokines and genes involved in cell cycle proliferation, together with the downregulation of extracellular matrix metallopeptidases, may represent a toxicological response to cigarette smoke exposure, with potential repercussion for the processes of uterine remodeling and growth that are essential for uterine receptiveness. A recommendation to expand upon this research area is made. © 2021 Wiley Periodicals LLC.
Cytologic features of malignant rhabdoid tumor of the liver: A case report and literature review
Authors: Liu Hao , Bruner Evelyn T. , Yang Jack 
Published: June 2021

AbstractAs one of the SMARCB1‐deficient tumors, malignant rhabdoid tumor (MRT) of the liver is a rare and aggressive malignancy, typically in young children below the age of 3 years. The diagnosis of MRT of the liver is challenging both clinically and pathologically due to the rarity of the tumor and misdiagnosing it as a hepatoblastoma is not uncommon. Although MRT of the liver and hepatoblastoma share some similar clinical and morphological features, their prognosis and the clinical management are significantly different. Therefore, an accurate diagnosis of MRT or hepatoblastoma is critical for patient care. Here we report a case of an 8‐month‐old female with MRT of the liver diagnosed by fine needle aspiration and core biopsy. The cytologic and histological features, the results of immunohistochemical studies, and clinical follow‐up information are presented. Recent literature regarding the diagnosis and treatment of this tumor were reviewed.
What's in fake ‘Xanax’?: A dosage survey of designer benzodiazepines in counterfeit pharmaceutical tablets
Authors: Blakey Karen , Thompson Amanda , Matheson Abbey , Griffiths Andrew 
Published: June 2021

AbstractThe identification of a range of different drugs within counterfeit benzodiazepine tablets has been widely reported; however, limited information is available on the dosage of these products. A rapid dosage survey of 46 counterfeit benzodiazepine tablets from 20 seizures was conducted over a 6‐month period between April and September 2020. Existing methods utilised for the determination of benzodiazepines in toxicology specimens were applied to assess the dosage of four benzodiazepines detected across five different counterfeit benzodiazepine presentations. The highest dosage variation was observed for etizolam with a range of 0.7–8.3 mg per tablet. This report demonstrates the variability in drug content and dosage that can occur between visually similar counterfeit tablets, even when co‐packaged within the same seizure, highlighting the potential public harm posed by these counterfeit medications.
Metadata Made Easy: Develop and Use Domain‐Specific Metadata Schemes by following the dmdScheme approach
Authors: Krug Rainer M. , Petchey Owen L. 
Published: June 2021

Abstract

Metadata plays an essential role in the long‐term preservation, reuse, and interoperability of data. Nevertheless, creating useful metadata can be sufficiently difficult and weakly enough incentivized that many datasets may be accompanied by little or no metadata. One key challenge is, therefore, how to make metadata creation easier and more valuable. We present a solution that involves creating domain‐specific metadata schemes that are as complex as necessary and as simple as possible. These goals are achieved by co‐development between a metadata expert and the researchers (i.e., the data creators). The final product is a bespoke metadata scheme into which researchers can enter information (and validate it) via the simplest of interfaces: a web browser application and a spreadsheet.

We provide the R package dmdScheme (dmdScheme: An R package for working with domain specific MetaData schemes (Version v0.9.22), 2019) for creating a template domain‐specific scheme. We describe how to create a domain‐specific scheme from this template, including the iterative co‐development process, and the simple methods for using the scheme, and simple methods for quality assessment, improvement, and validation.

The process of developing a metadata scheme following the outlined approach was successful, resulting in a metadata scheme which is used for the data generated in our research group. The validation quickly identifies forgotten metadata, as well as inconsistent metadata, therefore improving the quality of the metadata. Multiple output formats are available, including XML.

Making the provision of metadata easier while also ensuring high quality must be a priority for data curation initiatives. We show how both objectives are achieved by close collaboration between metadata experts and researchers to create domain‐specific schemes. A near‐future priority is to provide methods to interface domain‐specific schemes with general metadata schemes, such as the Ecological Metadata Language, to increase interoperability.
Community action on natural flood management and the governance of acatchment‐basedapproach in theUK
Authors: Garvey Alice , Paavola Jouni 
Published: June 2021

AbstractThere is increasing interest in natural flood management (NFM) and the delivery of public environmental goods. Yet the implementation of NFM can be ad‐hoc and is regionally diverse. Communities often play a role in NFM and thus we assess NFM governance in the UK and communities' position within it. We develop a theoretical framework using the concepts of public goods, social capital, collective action and polycentrism and use it to examine the governance of the design and implementation of NFM in Pickering and Calderdale in Yorkshire, to contribute to a debate on how NFM should be managed, by whom, and under what governance arrangements. Drawing on stakeholder interviews, we find that the participation of community flood groups (CFGs) in NFM improved community access to strategic conversations on flood risk management (FRM). In turn CFGs raised the public profile of NFM, enabled the deployment of NFM measures, and helped to generate the evidence base on them. We conclude that there is a need for a polycentric communityandcatchment‐based approach to better coordinate NFM governance across and between scales, to support community access and contribution to flood risk strategy, and to foster sustainable flood risk management.
“Nothing Feels Better than Getting Paid”: Sex Working Trans Latinas’ Meanings and Uses of Money
Authors: Bolivar Andrea 
Published: June 2021

AbstractBased on ethnographic research with transgender Latinas in Chicago, this article answers Susana Narotzky and Niko Besnier's (2014) invitation to think “economy otherwise.” I contend that in order to think “economy otherwise” we must think it queerly, and attend to feminist ways money animates possibilities beyond racist‐cisgenderism. I bring together economic anthropology, feminist anthropology, and queer of color critique to queer money, specifically money earned from sexual labor performed by transgender Latinas. An ethnographic examination of trans Latina sex workers’ lives reveals that money accessed through sexual labor is assigned a number of queer and contested meanings. Its use is based in feminist ethics that eschew dominant economic logics in favor of building relations of care. It enables the creation of transgender bodies, and the development of queer networks of care with biological and chosen kin, in the U.S. and beyond. Trans Latinas, then, use money from sex work to support trans Latina ways of being that exceed the racist‐cisgenderism. Sometimes, however, their uses of money reinforce racist‐cisgenderism. I argue that the women's fraught uses of money reveal the complex intersections that sustain racist‐cisgenderism, and how they are experienced and negotiated in people's everyday lives.
Dietary phytochemicals modulate intestinal epithelial barrier dysfunction and autoimmune diseases
Authors: Ganesan Kumar , Quiles José L. , Daglia Maria , Xiao Jianbo , Xu Baojun 
Published: June 2021

AbstractThe intestinal epithelium acts as a key defensive barrier that protects internal organs from the detrimental gut environment. The homeostasis of the gut epithelium may be altered by environmental conditions and exogenous pathogens that can impair the integrity of the gut barrier, leading to immune response associated with low‐grade systemic inflammation, a known contributor to metabolic and inflammatory diseases. Autoimmune diseases (ADs) are a collection of abnormalities of the immune system, in which the immune system of an individual acts against healthy organs or systems, due to a failure in antigenic recognition. Hence, this review aims to focus on modulators of intestinal epithelial barrier dysfunction with effects on autoimmune disorders. All data on dietary phytochemicals and their impact on the modulation of the intestinal epithelium barrier and various ADs were collected from electronic searches of library databases (PubMed, Science Direct, and Google Scholar). An electronic search was conducted using PubMed, Science Direct, and Google Scholar by finding the keywords “phytochemicals” AND “bioactive compounds” AND “flavonoids” AND “polyphenols” OR “intestinal epithelium barrier” OR “autoimmune diseases” OR “inflammatory diseases” in “Title/Abstract/Keywords,” with the date from January 2011 to December 2020, to identify all published studies (in vitro, in vivo, clinical, and case‐control) that have investigated the connection between dietary phytochemicals and their various beneficial effects. Dietary phytochemicals are promising key modulators, stabilizing the integrity of the intestinal barrier and attenuating the progression of ADs. Health‐modulatory information was gathered and orchestrated in a suitable place in this review.
Best Practices for Communicating Climate Science for Fisheries Professionals
Authors: Neal J Wesley , Claussen Julie E , Douglas Marlis R , Spencer Erin T , Tracy Erin , Blasius Heidi , Mackey Theresa , Hall Carolyn J , Kusnierz Paul C , Douglas Michael E , Bonar Scott 
Published: June 2021

Abstract
Climate change has been documented for over 120 years with increasing scientific rigor, and its impacts are already observable in marine and freshwater fisheries. But after decades of communication to underscore the validity of these changes, and the urgency for action, a large component of the public and many elected officials deny the scientific consensus and reject the need for action. Therefore, we outline a more effective strategy to convey the climate message to stakeholders and inspire them to act.
The impact of graph construction scheme and community detection algorithm on the repeatability of community and hub identification in structural brain networks
Authors: Dimitriadis Stavros I. , Messaritaki Eirini , K. Jones Derek 
Published: June 2021

AbstractA critical question in network neuroscience is how nodes cluster together to form communities, to form the mesoscale organisation of the brain. Various algorithms have been proposed for identifying such communities, each identifying different communities within the same network. Here, (using test–retest data from the Human Connectome Project), the repeatability of thirty‐three community detection algorithms, each paired with seven different graph construction schemes were assessed. Repeatability of community partition depended heavily on both the community detection algorithm and graph construction scheme. Hard community detection algorithms (in which each node is assigned to only one community) outperformed soft ones (in which each node can belong to more than one community). The highest repeatability was observed for the fast multi‐scale community detection algorithm paired with a graph construction scheme that combines nine white matter metrics. This pair also gave the highest similarity between representative group community affiliation and individual community affiliation. Connector hubs had higher repeatability than provincial hubs. Our results provide a workflow for repeatable identification of structural brain networks communities, based on the optimal pairing of community detection algorithm and graph construction scheme.
Survival and toxicity in patients with human papilloma virus‐associated oropharyngeal squamous cell cancer receiving trimodality therapy including transoral robotic surgery
Authors: Sun Lova , Shimunov David , Tan Erik X. , Swisher‐Mcclure Samuel , Lin Alexander , Lukens John N. , Basu Devraj , Chalian Ara A. , Cannady Steven B. , Newman Jason G. , Rajasekaran Karthik , O'Malley Bert W. , Rassekh Christopher H. , Weinstein Gregory S. , Loevner Laurie A. , Aggarwal Charu , Singh Aditi , Cohen Roger B. , Bauml Joshua M. , Brody Robert M. 
Published: June 2021

AbstractBackgroundPatients with oropharyngeal cancer who undergo transoral robotic surgery (TORS) and have high‐risk features generally receive adjuvant chemoradiotherapy or trimodality therapy (TMT). The notion that TMT leads to high toxicity is largely based on studies that included human papilloma virus (HPV)‐negative cancers and/or nonrobotic surgery; we sought to describe outcomes in HPV‐associated oropharyngeal squamous cell cancer (HPV + OPSCC) undergoing TORS‐TMT.MethodsIn consecutive patients with HPV + OPSCC receiving TMT at an academic center from 2010 to 2017, survival was estimated using Kaplan–Meier methodology, and toxicities were ascertained via chart review.ResultsIn our cohort of 178 patients, 5‐year survival was 93.6%. Feeding tube rates were 25.8% at therapy completion and 0.7% at 1 year. Rates of grade ≥ 3 kidney injury, anemia, and neutropenia in cisplatin‐treated patients were 2.7%, 3.4%, and 11.0%, respectively.ConclusionsPatients with HPV + OPSCC who underwent TORS‐TMT had excellent survival and low rates of toxicity and feeding tube dependence. These outcomes compare favorably to historical cohorts treated with definitive chemoradiotherapy.
Splicing Factor SLU7 Prevents Oxidative Stress‐Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage
Authors: Gárate‐Rascón María , Recalde Miriam , Jimenez Maddalen , Elizalde María , Azkona María , Uriarte Iker , Latasa M. Uxue , Urtasun Raquel , Bilbao Idoia , Sangro Bruno , Garcia‐Ruiz Carmen , Fernandez‐Checa José C. , Corrales Fernando J , Esquivel Argitxu , Pineda‐Lucena Antonio , Fernández‐Barrena Maite G. , Ávila Matías A. , Arechederra María , Berasain Carmen 
Published: June 2021

Background and Aims
Hepatocellular dedifferentiation is emerging as an important determinant in liver disease progression. Preservation of mature hepatocyte identity relies on a set of key genes, predominantly the transcription factor hepatocyte nuclear factor 4α (HNF4α) but also splicing factors like SLU7. How these factors interact and become dysregulated and the impact of their impairment in driving liver disease are not fully understood.

Approach and Results
Expression of SLU7 and that of the adult and oncofetal isoforms of HNF4α, driven by its promoter 1 (P1) and P2, respectively, was studied in diseased human and mouse livers. Hepatic function and damage response were analyzed in wild‐type and Slu7‐haploinsufficient/heterozygous (Slu7+/−
) mice undergoing chronic (CCl4) and acute (acetaminophen) injury. SLU7 expression was restored in CCl4‐injured mice using SLU7‐expressing adeno‐associated viruses (AAV‐SLU7). The hepatocellular SLU7 interactome was characterized by mass spectrometry. Reduced SLU7 expression in human and mouse diseased livers correlated with a switch in HNF4α P1 to P2 usage. This response was reproduced in Slu7+/−
mice, which displayed increased sensitivity to chronic and acute liver injury, enhanced oxidative stress, and marked impairment of hepatic functions. AAV‐SLU7 infection prevented liver injury and hepatocellular dedifferentiation. Mechanistically we demonstrate a unique role for SLU7 in the preservation of HNF4α1 protein stability through its capacity to protect the liver against oxidative stress. SLU7 is herein identified as a key component of the stress granule proteome, an essential part of the cell’s antioxidant machinery.

Conclusions
Our results place SLU7 at the highest level of hepatocellular identity control, identifying SLU7 as a link between stress‐protective mechanisms and liver differentiation. These findings emphasize the importance of the preservation of hepatic functions in the protection from liver injury.