bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seamless multi-reticle photonics
Authors: Jin Warren , Feshali Avi , Paniccia Mario , Bowers John E. 
Published: May 2021

While Moore’s law predicted shrinking transistors would enable exponential scaling of electronic circuits, the footprint of photonic components is limited by the wavelength of light. Thus, future high-complexity photonic integrated circuits (PICs) such as petabit-per-second transceivers, thousand-channel switches, and photonic quantum computers will require more area than a single reticle provides. In our novel approach, we overlay and widen waveguides in adjacent reticles to stitch a smooth transition between misaligned exposures. In SiN waveguides, we measure ultralow loss of 0.0004 dB per stitch, and produce a stitched delay line 23 m in length. We extend the design to silicon channel waveguides, and predict 50-fold lower loss or 50-fold smaller footprint versus a multimode-waveguide-based method. Our approach enables large-scale PICs to scale seamlessly beyond the single-reticle limit.
Positron emission tomography and magnetic resonance imaging in experimental human malaria to identify organ-specific changes in morphology and glucose metabolism: A prospective cohort study
Authors: Woodford John , Gillman Ashley , Jenvey Peter , Roberts Jennie , Woolley Stephen , Barber Bridget E. , Fernandez Melissa , Rose Stephen , Thomas Paul , Anstey Nicholas M. , McCarthy James S. 
Published: May 2021

Background
Plasmodium vivax has been proposed to infect and replicate in the human spleen and bone marrow. Compared to Plasmodium falciparum, which is known to undergo microvascular tissue sequestration, little is known about the behavior of P. vivax outside of the circulating compartment. This may be due in part to difficulties in studying parasite location and activity in life.

Methods and findings
To identify organ-specific changes during the early stages of P. vivax infection, we performed 18-F fluorodeoxyglucose (FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) at baseline and just prior to onset of clinical illness in P. vivax experimentally induced blood-stage malaria (IBSM) and compared findings to P. falciparum IBSM. Seven healthy, malaria-naive participants were enrolled from 3 IBSM trials: NCT02867059, ACTRN12616000174482, and ACTRN12619001085167. Imaging took place between 2016 and 2019 at the Herston Imaging Research Facility, Australia. Postinoculation imaging was performed after a median of 9 days in both species (n = 3 P. vivax; n = 4 P. falciparum). All participants were aged between 19 and 23 years, and 6/7 were male. Splenic volume (P. vivax: +28.8% [confidence interval (CI) +10.3% to +57.3%], P. falciparum: +22.9 [CI −15.3% to +61.1%]) and radiotracer uptake (P. vivax: +15.5% [CI −0.7% to +31.7%], P. falciparum: +5.5% [CI +1.4% to +9.6%]) increased following infection with each species, but more so in P. vivax infection (volume: p = 0.72, radiotracer uptake: p = 0.036). There was no change in FDG uptake in the bone marrow (P. vivax: +4.6% [CI −15.9% to +25.0%], P. falciparum: +3.2% [CI −3.2% to +9.6%]) or liver (P. vivax: +6.2% [CI −8.7% to +21.1%], P. falciparum: −1.4% [CI −4.6% to +1.8%]) following infection with either species. In participants with P. vivax, hemoglobin, hematocrit, and platelet count decreased from baseline at the time of postinoculation imaging. Decrements in hemoglobin and hematocrit were significantly greater in participants with P. vivax infection compared to P. falciparum. The main limitations of this study are the small sample size and the inability of this tracer to differentiate between host and parasite metabolic activity.

Conclusions
PET/MRI indicated greater splenic tropism and metabolic activity in early P. vivax infection compared to P. falciparum, supporting the hypothesis of splenic accumulation of P. vivax very early in infection. The absence of uptake in the bone marrow and liver suggests that, at least in early infection, these tissues do not harbor a large parasite biomass or do not provoke a prominent metabolic response. PET/MRI is a safe and noninvasive method to evaluate infection-associated organ changes in morphology and glucose metabolism.
Mycobacterium leprae transmission characteristics during the declining stages of leprosy incidence: A systematic review
Authors: Hambridge Thomas , Nanjan Chandran Shri Lak , Geluk Annemieke , Saunderson Paul , Richardus Jan Hendrik 
Published: May 2021

BackgroundLeprosy is an infectious disease caused byMycobacterium leprae. As incidence begins to decline, the characteristics of new cases shifts away from those observed in highly endemic areas, revealing potentially important insights into possible ongoing sources of transmission. We aimed to investigate whether transmission is driven mainly by undiagnosed and untreated new leprosy cases in the community, or by incompletely treated or relapsing cases.Methodology/Principal findingsA literature search of major electronic databases was conducted in January, 2020 with 134 articles retained out of a total 4318 records identified (PROSPERO ID: CRD42020178923). We presented quantitative data from leprosy case records with supporting evidence describing the decline in incidence across several contexts. BCG vaccination, active case finding, adherence to multidrug therapy and continued surveillance following treatment were the main strategies shared by countries who achieved a substantial reduction in incidence. From 3950 leprosy case records collected across 22 low endemic countries, 48.3% were suspected to be imported, originating from transmission outside of the country. Most cases were multibacillary (64.4%) and regularly confirmed through skin biopsy, with 122 cases of suspected relapse from previous leprosy treatment. Family history was reported in 18.7% of cases, while other suspected sources included travel to high endemic areas and direct contact with armadillos. None of the countries included in the analysis reported a distinct increase in leprosy incidence in recent years.Conclusions/SignificanceTogether with socioeconomic improvement over time, several successful leprosy control programmes have been implemented in recent decades that led to a substantial decline in incidence. Most cases described in these contexts were multibacillary and numerous cases of suspected relapse were reported. Despite these observations, there was no indication that these cases led to a rise in new secondary cases, suggesting that they do not represent a large ongoing source of human-to-human transmission.
Sepsis in two hospitals in Rwanda: A retrospective cohort study of presentation, management, outcomes, and predictors of mortality
Authors: Hopkinson Dennis A. , Mvukiyehe Jean Paul , Jayaraman Sudha P. , Syed Aamer A. , Dworkin Myles S. , Mucyo Willy , Cyuzuzo Thierry , Tuyizere Anne , Mukwesi Christian , Nyirigira Gaston , Banguti Paulin R. , Riviello Elisabeth D. 
Published: May 2021

Purpose
Few studies have assessed the presentation, management, and outcomes of sepsis in low-income countries (LICs). We sought to characterize these aspects of sepsis and to assess mortality predictors in sepsis in two referral hospitals in Rwanda.

Materials and methods
This was a retrospective cohort study in two public academic referral hospitals in Rwanda. Data was abstracted from paper medical records of adult patients who met our criteria for sepsis.

Results
Of the 181 subjects who met eligibility criteria, 111 (61.3%) met our criteria for sepsis without shock and 70 (38.7%) met our criteria for septic shock. Thirty-five subjects (19.3%) were known to be HIV positive. The vast majority of septic patients (92.7%) received intravenous fluid therapy (median = 1.0 L within 8 hours), and 94.0% received antimicrobials. Vasopressors were administered to 32.0% of the cohort and 46.4% received mechanical ventilation. In-hospital mortality for all patients with sepsis was 51.4%, and it was 82.9% for those with septic shock. Baseline characteristic mortality predictors were respiratory rate, Glasgow Coma Scale score, and known HIV seropositivity.

Conclusions
Septic patients in two public tertiary referral hospitals in Rwanda are young (median age = 40, IQR = 29, 59) and experience high rates of mortality. Predictors of mortality included baseline clinical characteristics and HIV seropositivity status. The majority of subjects were treated with intravenous fluids and antimicrobials. Further work is needed to understand clinical and management factors that may help improve mortality in septic patients in LICs.
Ethyl ferulate contributes to the inhibition of the inflammatory responses in murine RAW 264.7 macrophage cells and acute lung injury in mice
Authors: Wang Yu , Zhang Xuan , Li Linger , Zhang Zhao , Wei Chengxi , Gong Guohua 
Published: May 2021

Background
Ethyl ferulate (EF) is a derivative of ferulic acid (FA), which is a monomeric component purified from the traditional medicinal herb Ferula, but its effects have not been clear yet. The purpose of this study was to evaluate whether EF can reduce inflammation levels in macrophages by regulating the Nrf2-HO-1 and NF-кB pathway.

Methods
The LPS-induced raw 264.7 macrophage cells model was used to determine the anti-inflammatory and anti-oxidative stress effects of EF. The levels of IL-1β, IL-6, TNF-α and PGE2 were analyzed by ELISA. The mRNA and protein of COX-2, iNOS, TNF-α, IL-6, HO-1 and Nrf2 were identified by RT-PCR analysis and western blotting. Intracellular ROS levels were assessed with DCFH oxidation staining. The expressions of NF-кB p-p65 and Nrf2 were analyzed by immunofluorescence assay. The inhibitory effect of Nrf2 inhibitor ML385 (2μM) on mediatation of antioxidant activity by raw 264.7 macrophage cells was evaluated. The effect of EF was confirmed in acute lung injury mice model.

Results
In our research, EF reduced the expression of iNOS, COX2 and the production of PGE2. EF could inhibit the production of pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α) in lipopolysaccharide (LPS) stimulated macrophages and decreased expression of IL-6 and TNF-α in LPS stimulated macrophages. Furthermore, EF inhibited NF-кB p65 from transporting to the nucleus, decreased the expression of p-IкBα, significantly decreased the level of intracellular reactive oxygen species (ROS) and activated Nrf2/HO-1 pathways. EF could attenuate the degree of leukocyte infiltration, reduced MPO activity, mRNA levels and secretion of TNF-α and IL-6 in vivo. EF exhibited potent protective effects against LPS-induced acute lung injury in mice.

Conclusions
Collectively, our data showed that EF relieved LPS-induced inflammatory responses by inhibiting NF-κB pathway and activating Nrf2/HO-1 pathway, known to be involved in the regulation of inflammatory responses by Nrf2.
Survival, health care resource utilization and expenditures of first-line treatments for multiple myeloma patients ineligible for transplant in Taiwan
Authors: Cheng Chih-Ning , Huang Shang-Yi , Lien Pei-Wen , Huang Shih-Ting , Lin Fang-Ju 
Published: May 2021

Background
We aimed to provide real-world information on survival, health care resource utilization (HCRU), and expenditures related to various first lines of therapy (1LOTs) in newly diagnosed multiple myeloma (NDMM) patients who were transplant ineligible (TI).

Patients and methods
From the Taiwan National Health Insurance Database (2008–2016), we identified 1,511 NDMM-TI patients who had received 1LOT since June 2012. We categorized 1LOT regimens into four groups: bortezomib (V)+thalidomide (T), V, T, and non-V/T. Patients’ characteristics were collected. The overall survival (OS), event-free survival (EFS), frequencies of HCRU (hospitalization, visiting outpatient and emergency departments), and related expenditures within one year after commencement of the 1LOT were evaluated and compared.

Results
The mean age of the included patients was 71.3 (SD 10.7) years, and 40.4% of patients had a CCI score ≥3. Most patients (747; 49.4%) were in the V+T group and, after adjusting for covariates, had a significantly longer OS (median, 22.2 months) and EFS (9.1 months) than those in the T group (12.6 and 4.5 months, respectively) and the non-V/T group (12.2 and 3.2 months, respectively), but they were mostly comparable with patients in the V group (23.8 and 6.6 months, respectively). Compared to those in the V+T group, patients in the T and non-V/T groups had 29% and 39% fewer outpatient visits and 15% and 24% lower total expenditure, respectively.

Conclusion
Our real-world data consolidate evidence for the effectiveness of bortezomib-containing regimens as the 1LOT in NDMM-TI patients at the expense of more outpatient visits and higher total costs.
Visualizing the discourse in Material Thinking: Conversations between China and South Africa, Chen Qingqing, Feng Jiali, Gu Lin, Liu Liguo, Qi Zhilong, Qing Taimao, Wang Xiaojin and Zhong Biao (China); William Kentridge, Diane Victor, Colbert Mashile, Kristin NG-Yang and Rory Klopper (South Africa), curated by Zhang Siyong
Authors: Morgan Trevor 
Published: May 2021

Visualizing the discourse in Material Thinking: Conversations between China and South Africa, Chen Qingqing, Feng Jiali, Gu Lin, Liu Liguo, Qi Zhilong, Qing Taimao, Wang Xiaojin and Zhong Biao (China); William Kentridge, Diane Victor, Colbert Mashile, Kristin NG-Yang and Rory Klopper (South Africa), curated by Zhang Siyong
Durban Art Gallery, South Africa, 12 September–10 November 2019
Cyclosporine-Induced Kaposi Sarcoma in a Patient With Ulcerative Colitis
Authors: Clarke Lindsay M. , Chawla Karan , Tabbara Nadeem , Szvarca Daniel , Stachura Anna , Theisen Brian , Chandler Matthew , Borum Marie L. 
Published: May 2021

ABSTRACT
Kaposi sarcoma (KS) is an angioproliferative neoplasm associated with human herpesvirus-8. Gastrointestinal KS has been well documented in immunosuppressed solid organ transplant patients, with only 26 iatrogenic cases published in patients with inflammatory bowel disease. We report a 24-year-old patient with ulcerative colitis, maintained on cyclosporine for 2 years, who presented with watery, nonbloody diarrhea and weight loss. Colonoscopy revealed human herpesvirus-8-positive hemorrhagic nodules throughout the colon and terminal ileum, with diffuse lymphadenopathy on computed tomography consistent with KS. As gastrointestinal KS may present with symptoms that mimic inflammatory bowel disease, it is critical to maintain suspicion in patients on prolonged immunosuppression to reduce complications.
TeleInGEstion Remote Video Capsule Endoscope
Authors: Sreenivasan Aditya , She Tianyu , Gross Seth , Storch Ian 
Published: May 2021

ABSTRACT
We describe 2 cases in which video capsule endoscopy was performed remotely using TeleInGEstion Remote Video Capsule Endoscopy (TIGER VCE), given limited access to endoscopy during the COVID-19 pandemic. The patients ingested the CapsoCam capsule during a televisit, and the video was subsequently reviewed remotely by the physician. TIGER VCE was used to diagnose a benign etiology of melena and used to confirm a diagnosis of Crohn's disease before the initiation of biologic therapy. These cases demonstrate the safety and efficacy of TIGER VCE. We feel that this technique may be considered as a standard ingestion technique in the future.
Existence for singular critical exponential (𝑝, 𝑄) equations in the Heisenberg group
Authors: Pucci Patrizia , Temperini Letizia 
Published: May 2021

AbstractThe paper deals with the existence of nontrivial solutions for(p,Q)(p,Q)equations in the Heisenberg groupHn\mathbb{H}^{n}with critical exponential growth at infinity and a singular behavior at the origin. The main features and novelty of the paper are the above generality on the right-hand side of the equation, the(p,Q)(p,Q)growth of the elliptic operator and the fact that the equation is studied in the entire Heisenberg group.
Individual variation in attitudes towards Chinese-English code-switching
Authors: Liu Hong 
Published: May 2021

AbstractThis paper aims to improve our understanding of the social psychology of code-switching by investigating societal attitudes towards two types of Chinese-English code-switching, insertions of English words in Chinese sentences and switching to English at clausal boundaries in Chinese. It examines how subjects’ evaluation of code-switching is influenced by their general language attitudes and language use associated with network exposure. The subjects were recruited from four different cities in mainland China. They participated in an online perception experiment and completed a socio-biographical questionnaire. Quantitative analyses show that clausal switching was rated as the least likable CS mode, but at the same time was considered as having high status as an indication of high English proficiency. Their evaluation was mainly influenced by their general attitudes towards English language and culture. Network exposure also played a marginal role, affecting their judgement of the speaker’s English proficiency.
The effect of abdominal massage (I Love You method) on the gastric function of preterm infants hospitalized in the neonatal intensive care units: a randomized clinical trial
Authors: Moghadam Azadeh , Nematollahi Monirsadat , OstadEbrahimi Hamid , Mehdipour-Rabori Roghayeh 
Published: May 2021

Abstract

Objectives
Preterm infants often suffer from nutritional problems because of gastrointestinal problems. Massage could make the infants feel more peace and comfort, but limited studies have focused on the effects of massage on the gastric function. This study aimed to investigate the effects of abdominal massage on the gastric function of preterm infants.

Methods
A randomized controlled trial compared gastric function of preterm infants with and without massage therapy. The preterm infants were randomly allocated to control and massage groups. The massage group received the abdominal massage before feeding, twice a day, for 15 min, over 5 days. Furthermore, the gastric function was compared between the control and experimental groups. The data were analyzed using SPSS software (Version 15.0).

Results
The average weight in both groups had no significant (p>0.05) changes before and after the study, and both groups showed a negative trend in the weight gain. The abdominal circumference, the frequency of vomiting episodes, the residual volume, and defecation frequency were significantly (p<0.05) different between the two groups after the intervention.

Conclusions
The abdominal massage could be an effective nonmedicinal method to reduce the gastrointestinal problems in the preterm infants. The abdominal massage could be offered to the preterm infants as an inexpensive, available, and feasible method to alleviate gastrointestinal problems as well as improve the gastric function.
Complexation of Cm(III) with blood serum proteins: recombinant human serum albumin (rHSA)
Authors: Adam Nicole , Reitz Cédric Y. , Ditter Anna-Lena , Panak Petra J. 
Published: May 2021

Abstract
The complexation of Cm(III) with the recombinant human serum albumin (rHSA) (characterized by single deletion of residue Asp-1), is studied in dependence of pH and rHSA concentration using time-resolved laser fluorescence spectroscopy (TRLFS). A Cm(III) rHSA species is formed between pH 6.4 and 10.0 with the conditional stability constant being logK = 6.47 at pH = 7.4. Competition titration experiments with Cu(II) and Zn(II) confirm complexation at the N-terminal binding site (NTS) of rHSA and exclude the involvement of the Multi-Metal Binding Site (MBS). Comparison with a previous study on Cm(III) interaction with native albumin, HSA, points out, that residue Asp-1 is involved in Cm(III) binding to HSA but is not crucial for Cm(III) complexation at the NTS. The results are of major importance for a better understanding of fundamental actinide-protein interaction mechanisms which are highly required for the identification and characterization of relevant distribution pathways of incorporated radionuclides.
To which extent are per-and poly-fluorinated substances associated to metabolic syndrome?
Authors: Zare Jeddi Maryam , Soltanmohammadi Rozita , Barbieri Giulia , Fabricio Aline S. C. , Pitter Gisella , Dalla Zuanna Teresa , Canova Cristina 
Published: May 2021

Abstract
Exposure to per- and polyfluoroalkyl substances (PFAS), ubiquitous persistent environmental contaminants, has led to substantial global concern due to their potential environmental and human health effects. Several epidemiological studies have assessed the possible association between PFAS exposure and risk of metabolic syndrome (MetS), however, the results are ambiguous. The aim of this study was to assess the current human epidemiologic evidence on the association between exposure to PFAS and MetS. We performed a systematic search strategy using three electronic databases (PubMed, Scopus, and Web of Science) for relevant studies concerning the associations of PFAS with MetS and its clinical relevance from inception until January 2021. We undertook meta-analyses where there were five or more studies with exposure and outcomes assessments that were reasonably comparable. The pooled odd ratios (ORs) were calculated using random effects models and heterogeneity among studies was assessed by I2 index and Q test. A total of 12 cross-sectional studies (10 studies on the general population and two studies in the occupational settings) investigated the association between PFAS exposure and MetS. We pooled data from seven studies on the general population for perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) and five studies for perfluorohexanesulfonate (PFHxS) and perfluorononanoic acid (PFNA). Predominately, most studies reported no statistically significant association between concentrations of PFAS and MetS. In the meta-analysis, the overall measure of effect was not statistically significant, showing no evidence of an association between concentrations of PFOA, PFOS, PFNA, and PFHxS and the risk of MetS. Based on the results of the meta-analysis, current small body of evidence does not support association between PFAS and MetS. However, due to limited number of studies and substantial heterogeneity, results should be interpreted with caution. Further scrutinizing cohort studies are needed to evaluate the association between various and less well-known PFAS substances and their mixture with MetS and its components in both adults and children in different settings.
Oxidative stress and cyto-genotoxicity induced by poly-d-glucosamine in human blood cells in vitro
Authors: Cerig Salim , Geyikoglu Fatime 
Published: May 2021

Abstract
Poly-N-acetyl-d-glucosamine (CH; chitin) is the main component of the insect skeleton, fungal cell wall, and many crustaceans, including crab and shrimp. CH is the most abundant in nature after cellulose, and it has a complex and hardly soluble structure. Poly-d-glucosamine (CHO; chitosan) is a soluble derivative of CH produced by deacetylation used in many fields, including human health. This study carried out the cytotoxic, genotoxic, and oxidative effects of CHO on human whole blood (hWB) and lymphocytes (LYMs) in dose ranges 6.25–2000 μg/mL, in vitro. Total antioxidant capacity (TAC) and total oxidant status (TOS) analyzes were performed on plasma to appreciate oxidative stress. 3-(4,5-Dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays were applied to understand the cytotoxicity. Chromosomal aberration (CA) and micronucleus (MN) methods were practiced to evaluate genotoxicity. 6.25–150 μg/mL doses increased TAC and decreased TOS. A decreasing and increasing curve from 200 to 2000 μg/mL on TAC and TOS values were determined, respectively. 0–250 μg/mL doses did not provide any cytotoxic data. However, 500–2000 μg/mL doses showed increasing cytotoxicity and genotoxicity. The study results showed that CHO does not pose a toxic risk to human health at low doses but may pose a threat at high doses.