bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive telerehabilitation in neurological patients: systematic review and meta-analysis
Authors: Cacciante Luisa , Pietà Camilla della , Rutkowski Sebastian , Cieślik Błażej , Szczepańska-Gieracha Joanna , Agostini Michela , Kiper Pawel 
Published: November 2021

Abstract
Telerehabilitation (TR) seems to be an encouraging solution for the delivery of cognitive treatments in patients with neurological disorders. This study was aimed to analyze and synthesize the evidence on the efficacy of cognitive TR interventions in patients with neurological diseases, compared with conventional face-to-face rehabilitation. From a total of 4485 records, 9 studies met the inclusion criteria for qualitative analysis. At the end of the process, 7 studies remained for quantitative analysis. By comparing TR with face-to-face treatments for cognitive impairments, we assessed improvements in global cognitive domain (Mini Mental State Exam) (MD = −0.86; 95% CI −2.43, 0.72, I2 = 0%), in learning and memory domains (SMD = 0.26, 95% CI −0.22, 0.74, I2 = 24%), in verbal fluency (SMD = 0.08, 95% CI −0.47, 0.62, I2 = 0%), and in executive functions (i.e., problem-solving, central processing speed and working memory) (SMD = 0.38, 95% CI 0.06, 0.71, I2 = 0%). In all the included studies, improvement in the performance of the TR groups was comparable to that achieved through face-to-face intervention. Significant differences between those two modalities of providing treatments were observed for working memory and total executive function comparison, in favor of TR. The results of this study can sustain the efficacy of TR and its application for the treatment of neurological patients, especially when treated for executive function impairments.
Analysis of Flame Front Breaks Appearing in LES of Inhomogeneous Jet Flames Using Flamelets
Authors: Soli Alessandro , Langella Ivan , Chen Zhi X. 
Published: November 2021

AbstractThe physical mechanism leading to flame local extinction remains a key issue to be further understood. An analysis of large eddy simulation (LES) data with presumed probability density function (PDF) based closure (Chen et al., 2020, Combust. Flame, vol. 212, pp. 415) indicated the presence of localised breaks of the flame front along the stoichiometric line. These observations and their relation to local quenching of burning fluid particles, together with the possible physical mechanisms and conditions allowing their appearance in LES with a simple flamelet model, are investigated in this work using a combined Lagrangian-Eulerian analysis. The Sidney/Sandia piloted jet flames with compositionally inhomogeneous inlet and increasing bulk speeds, amounting to respectively 70 and 90% of the experimental blow-off velocity, are used for this analysis. Passive flow tracers are first seeded in the inlet streams and tracked for their lifetime. The critical scenario observed in the Lagrangian analysis, i.e., burning particles crossing extinction holes on the stoichiometric iso-surface, is then investigated using the Eulerian control-volume approach. For the 70% blow-off case the observed flame front breaks/extinction holes are due to cold and inhomogeneous reactants that are cast onto the stoichiometric iso-surface by large vortices initiated in the jet/pilot shear layer. In this case an extinction hole forms only when the strain effect is accompanied by strong subgrid mixing. This mechanism is captured by the unstrained flamelets model due to the ability of the LES to resolve large-scale strain and considers the SGS mixture fraction variance weakening effect on the reaction rate through the flamelet manifold. Only at 90% blow-off speed the expected limitation of the underlying combustion model assumption become apparent, where the amount of local extinctions predicted by the LES is underestimated compared to the experiment. In this case flame front breaks are still observed in the LES and are caused by a stronger vortex/strain interaction yet without the aid of mixture fraction variance. The reasons for these different behaviours and their implications from a physical and modelling point of view are discussed in this study.
Genetic programming for iterative numerical methods
Authors: Sobania Dominik , Schmitt Jonas , Köstler Harald , Rothlauf Franz 
Published: November 2021

AbstractWe introduce GPLS (Genetic Programming for Linear Systems) as a GP system that finds mathematical expressions defining an iteration matrix. Stationary iterative methods use this iteration matrix to solve a system of linear equations numerically. GPLS aims at finding iteration matrices with a low spectral radius and a high sparsity, since these properties ensure a fast error reduction of the numerical solution method and enable the efficient implementation of the methods on parallel computer architectures. We study GPLS for various types of system matrices and find that it easily outperforms classical approaches like the Gauss–Seidel and Jacobi methods. GPLS not only finds iteration matrices for linear systems with a much lower spectral radius, but also iteration matrices for problems where classical approaches fail. Additionally, solutions found by GPLS for small problem instances show also good performance for larger instances of the same problem.
T Cell Repertoire Abnormality in Immunodeficiency Patients with DNA Repair and Methylation Defects
Authors: Fang Mingyan , Su Zheng , Abolhassani Hassan , Zhang Wei , Jiang Chongyi , Cheng Bochen , Luo Lihua , Wu Jinghua , Wang Shiyu , Lin Liya , Wang Xie , Wang Longlong , Aghamohammadi Asghar , Li Tao , Zhang Xiuqing , Hammarström Lennart , Liu Xiao 
Published: November 2021

AbstractBoth DNA damage response and methylation play a crucial role in antigen receptor recombination by creating a diverse repertoire in developing lymphocytes, but how their defects relate to T cell repertoire and phenotypic heterogeneity of immunodeficiency remains obscure. We studied the TCR repertoire in patients with the mutation in different genes (ATM, DNMT3B,ZBTB24,RAG1,DCLRE1C, andJAK3) and uncovered distinct characteristics of repertoire diversity. We propose that early aberrancies in thymus T cell development predispose to the heterogeneous phenotypes of the immunodeficiency spectrum. Shorter CDR3 lengths in ATM-deficient patients, resulting from a decreased number of nucleotide insertions during VDJ recombination in the pre-selected TCR repertoire, as well as the increment of CDR3 tyrosine residues, lead to the enrichment of pathology-associated TCRs, which may contribute to the phenotypes of ATM deficiency. Furthermore, patients withDNMT3BandZBTB24mutations who exhibit discrepant phenotypes present longer CDR3 lengths and reduced number of known pathology-associated TCRs.
Upregulation of homeobox D10 expression suppresses invasion and migration of clear cell renal cell carcinoma through targeting of E-cadherin
Authors: Ren Zongtao , Niu Yunfeng , Fan Bo , Zhang Aili 
Published: November 2021

Abstract
Background
Clear cell renal cell carcinoma (CCRCC) is one of the most common types of renal cell carcinoma. Accumulating evidence indicates that homeobox D10 (HOXD10) acts as a tumor suppressor or oncogene in various carcinomas. However, the regulation and potential mechanisms of HOXD10 in CCRCC remain largely unknown.

Purpose
To explore the effect and potential mechanism of HOXD10 on the invasion and migration of CCRCC cells.

Methods
The expression of HOXD10, E-cadherin and other epithelial mesenchymal transition (EMT)-related proteins was assessed by reverse transcription-quantitative real-time PCR (qRT-PCR) and Western blots. A series of functional assays were performed in RCC cell lines to explore the function of HOXD10 in CCRCC progression. Bioinformatics analysis, ChIP assays, and dual luciferase reporter assays were utilized to identify the interaction between HOXD10 and E-cadherin.

Results
Low expression of HOXD10 and E-cadherin was observed in CCRCC tissues and ACHN and 786-O cells. Downregulation of HOXD10 expression was correlated with the TNM stage of CCRCC patients. Functional experiments demonstrated that malignant biological ability was significantly inhibited by HOXD10 overexpression in RCC cells. Moreover, E-cadherin was a potential target gene of HOXD10, as evidenced by a series of assays. In addition, overexpression of HOXD10 inhibited the progression of CCRCC by regulating the expression of E-cadherin, vimentin, and β-catenin in vitro.

Conclusion
HOXD10 acts as a tumor suppressor and suppresses invasion and migration of CCRCC cells by regulating E-cadherin and EMT processes. Thus, targeting HOXD10 may be a therapeutic strategy for CCRCC treatment.
Various brain-eating amoebae: the protozoa, the pathogenesis, and the disease
Authors: Zhang Hongze , Cheng Xunjia 
Published: November 2021

AbstractAmong various genera of free-living amoebae prevalent in nature, some members are identified as causative agents of human encephalitis, in whichNaegleria fowlerifollowed byAcanthamoebaspp. andBalamuthia mandrillarishave been successively discovered. As the three dominant genera responsible for infections,AcanthamoebaandBalamuthiawork as opportunistic pathogens of granulomatous amoebic encephalitis in immunocompetent and immunocompromised individuals, whereasNaegleriainduces primary amoebic meningoencephalitis mostly in healthy children and young adults as a more violent and deadly disease. Due to the lack of typical symptoms and laboratory findings, all these amoebic encephalitic diseases are difficult to diagnose. Considering that subsequent therapies are also affected, all these brain infections cause significant mortality worldwide, with more than 90% of the cases being fatal. Along with global warming and population explosion, expanding areas of human and amoebae activity in some regions lead to increased contact, resulting in more serious infections and drawing increased public attention. In this review, we summarize the present information of these pathogenic free-living amoebae, including their phylogeny, classification, biology, and ecology. The mechanisms of pathogenesis, immunology, pathophysiology, clinical manifestations, epidemiology, diagnosis, and therapies are also discussed.
Geophysical Studies for the Crust and Upper Mantle Structure of the Himalaya: Contributions of CSIR-NGRI
Authors: Manglik Ajay , Gupta Sandeep , Tiwari Virendra M. 
Published: November 2021

Abstract
The geologically young Himalayan mountain belt, a product of continued continent-continent collision, is a natural laboratory that has always been a sought after place for the global geoscience community to study geodynamics and natural hazards, besides many other aspects such as monsoon and climate, and natural resources. CSIR-NGRI, soon after its inception in 1961, initiated geophysical studies of the Himalaya and within the first decade a super-thick crust for the Himalaya-Tibet system by a surface wave study and upper mantle P-wave velocity down to 230 km for the Hindu Kush region by analysis of travel times of deep earthquakes were inferred. A few years later, the first ever trans-Himalayan deep seismic sounding (DSS) study by CSIR-NGRI provided further definitive evidence for crustal thickening and spatial variation of the Moho within the Kashmir Himalaya. In subsequent years, a number of seismological studies were launched, both in network and profile mode, in northeast India covering the Shillong Plateau, the eastern Himalaya, the Indo-Burmese Arc and the Assam valley, and in the northwest Himalaya covering mainly the Kumaun and Garhwal sectors. These studies yielded information about the Moho disposition, crust and upper mantle velocity structure, nature of the décollement surface, upper mantle discontinuities and the mantle transition zone, and seismic anisotropy. A good number of gravity and magnetotelluric studies have also been carried out by CSIR-NGRI to decipher the density structure, mechanical strength of the lithosphere and electrically conductive zones, respectively, and their possible correlation with seismicity. This review paper presents a synthesis of the geophysical studies carried out by CSIR-NGRI for imaging of the crust and upper mantle of the Himalayan collision belt.
Implementation of an Evidence-Based Intervention with Safety Net Clinics to Improve Mammography Appointment Adherence Among Underserved Women
Authors: Holcomb Jennifer , Rajan Suja S. , Ferguson Gayla M. , Sun Jiali , Walton Gretchen H. , Highfield Linda 
Published: November 2021

Abstract
The Peace of Mind Program is an evidence-based intervention to improve mammography appointment adherence in underserved women. The aim of this study was to assess effectiveness of the intervention and implementation of the intervention in safety net clinics. The intervention was implemented through a non-randomized stepped wedge cluster hybrid study design with 19 Federally Qualified Health Centers and charity care clinics within the Greater Houston area. A multivariable generalized estimating equation logistic regression was conducted to examine mammography appointment adherence. A survey assessing Consolidated Framework for Implementation Research constructs was also conducted with clinic staff prior to adoption and eight weeks post implementation. One-sided t-tests were conducted to analyze mean score changes between the surveys. A total of 4402 women (baseline period = 2078; intervention period = 2324) were included in the final regression analysis. Women in the intervention period were more likely to attend or reschedule their mammography appointment (OR = 1.30; p < 0.01) than those in the baseline period receiving usual care. Women who completed the intervention were more likely to attend or reschedule their mammography appointment than those who did not complete the intervention (OR = 1.62; p < 0.01). The mammography appointment no-show rates for those in the baseline period, in the intervention period, and who completed the intervention were, respectively, 22%, 19%, and 15%. A total of 15 clinics prior to adoption and eight clinics completed the survey at 8 weeks post implementation A statistically significant mean score decrease was observed in Inner Setting and in two Inner Setting CFIR constructs, Culture–Effort, and Implementation Climate. While the intervention improved mammography appointment adherence, there are opportunities to further integrate Consolidated Framework for Implementation Research constructs. Trial registration: Clinical trials registration number: NCT02296177.
Entwicklung von Praxiskompetenz durch Kooperationsprozesse von Lehrkräften
Authors: Bloh Thiemo 
Published: November 2021

ZusammenfassungLehrkräftekooperation wird generell eine positive Bedeutung in Bezug auf Schul- und Unterrichtsentwicklung zugeschrieben. Dabei sind empirische Belege für eine positive Wirksamkeit nach wie vor kaum vorhanden, es gibt sogar Befunde zu ‚negativen‘ Konsequenzen von Lehrkräftekooperation. Um diese Widersprüchlichkeit zu klären, wurde in der vorliegenden Arbeit Kooperation nicht als Instrument bzw. als Technik betrachtet, sondern als soziale Praxis verstanden, in der eigenlogisches, kollektiv-implizites Wissen (re)produziert wird (Community of Practice). Parallel dazu wurde ein praxeologisches Kompetenzverständnis (Praxiskompetenz) eingeführt, das wesentlich auf die Praxeologie Pierre Bourdieus zurückgeht und den Zusammenhang zwischen Lehrkräftekooperation als Community of Practice und kollektiv strukturierter, individueller Kompetenz theoretisch verdeutlicht. Die empirischen Befunde, welche mittels der Dokumentarischen Methode generiert wurden, verweisen auf die Bedeutung unterschiedlicher Relationslogiken (Nicht-Passung, Entfaltung, Herausforderung) für das ‚Lernen‘ von oder innerhalb von Praxiskompetenz(en) und damit auch auf die Wichtigkeit einer grundlegend kollektiv gerahmten Perspektive auf Lehrkräftekooperation. Vor diesem Hintergrund ist ein allzu positiver Blick auf Lehrkräftekooperationsprozesse kritisch zu betrachten.
The role of artificial intelligence in disinformation
Authors: Bontridder Noémi , Poullet Yves 
Published: November 2021

Abstract
Artificial intelligence (AI) systems are playing an overarching role in the disinformation phenomenon our world is currently facing. Such systems boost the problem not only by increasing opportunities to create realistic AI-generated fake content, but also, and essentially, by facilitating the dissemination of disinformation to a targeted audience and at scale by malicious stakeholders. This situation entails multiple ethical and human rights concerns, in particular regarding human dignity, autonomy, democracy, and peace. In reaction, other AI systems are developed to detect and moderate disinformation online. Such systems do not escape from ethical and human rights concerns either, especially regarding freedom of expression and information. Having originally started with ascending co-regulation, the European Union (EU) is now heading toward descending co-regulation of the phenomenon. In particular, the Digital Services Act proposal provides for transparency obligations and external audit for very large online platforms’ recommender systems and content moderation. While with this proposal, the Commission focusses on the regulation of content considered as problematic, the EU Parliament and the EU Council call for enhancing access to trustworthy content. In light of our study, we stress that the disinformation problem is mainly caused by the business model of the web that is based on advertising revenues, and that adapting this model would reduce the problem considerably. We also observe that while AI systems are inappropriate to moderate disinformation content online, and even to detect such content, they may be more appropriate to counter the manipulation of the digital ecosystem.
‘Exertion is not connected to success’: everyday Yoruba discourse of work and success
Authors: Agwuele Augustine 
Published: November 2021

AbstractWork hard, work smart, make the right connections, get the right education, invest wisely – yet after doing all the supposedly right things, success remains elusive to many. For a few, however, who may or may not have done exactly these things, success seems to come effortlessly. Some are very fortunate and others not so much. The lack of correspondence between exertion and success or work and good fortune is an issue that confronts lay persons and professionals alike. Focusing on Yoruba people, I discursively present lay Yoruba persons’ apprehension and common-sense view of this conundrum as reflected in their contextualized language use and supported by other ‘mundane’ information from day-to-day life. By looking at their everyday language, it is possible to deduce their reality as socially constructed in their discourses and gain insight into how they reconcile individual exertions with a view that asserts determinism. Further, I will suggest that the basis of the Yoruba conventional knowledge system informing their utterances and actions pertaining specifically to people's earthly fortunes lies in their origination narrative and original life quest, the essence of which remains inarguable even if temporarily pliable. The popular saying ‘iṣẹ́ o kan oríire’, exertion does not relate to success, is used as a point of departure and sense contained in their orature – situational utterances, pithy proverbs, aphorism and anecdotes – to tease out the Yoruba ordinary meaning of success/fortune and how it is acquired, relative to individuals’ earthly journey and preoccupation. Based on the sampled day-to-day utterances, individual life, it seems, unfolds as presumably scripted, despite apparent avowal and disavowal of ordination in people's pronouncements. Orí (head) retains its position at the summit, assenting – or not – to earthly endeavours.
Does pregnancy have an influence on otosclerosis?
Authors: Fabbris C , Molteni G , Tommasi N , Marchioni D 
Published: November 2021

AbstractObjectiveOtosclerosis affects women twice as often as men, especially during fertile age. A role of female hormones has been claimed, but controversy still exists regarding the influence of pregnancy. The purpose of this research was to analyse the role of pregnancy on the course of otosclerosis.MethodPubMed was searched in May 2019 using the terms ‘otosclerosis AND pregnancy’, ‘otosclerosis AND pregnant’, ‘otosclerosis AND parous’, ‘otosclerosis AND parity’, and ‘otosclerosis AND puerperium’. Age at diagnosis, number of pregnancies and the temporal relationship of the disease with childbearing were considered.ResultsFrom 65 articles, 11 were chosen for review. They described 2323 women affected by otosclerosis: 1805 had at least 1 pregnancy, while 518 did not. During childbearing, otosclerosis began in 1 per cent of pregnant women, worsened in 21 per cent and worsened during puerperium in 4 per cent. Often, the authors reported hearing change with pregnancy without details, so a further group has been considered composed of women belonging to any of the groups just mentioned or to another group of women not further characterised. Overall, hearing change occurred during pregnancy in 44 per cent. A statistically significant correlation emerged between hearing change and number of pregnancies (p= 0.003).ConclusionBecause of wide data heterogeneity and the difficulty in analysing a single factor, absolute statements could not be formulated. According to this review, pregnancy seems to have a worsening effect on the course of otosclerosis.
Presbylarynx: is diabetes mellitus a risk factor for vocal atrophy? A prospective case–control study
Authors: Santos M , Machado A , Vaz Freitas S , Almeida e Sousa C , Moreira da Silva Á 
Published: November 2021

AbstractObjectiveTo evaluate the prevalence of diabetes mellitus type 2 in subjects with presbylarynx.MethodA case–control, prospective study was carried out on consecutive subjects who presented to the otorhinolaryngology department.ResultsThe study comprised 174 subjects (60 males and 114 females) with a mean age of 73.99 years (65–95 years). Presbylarynx was identified in 71 patients (41 per cent). Among patients with diabetes mellitus type 2, 20 patients (77 per cent) exhibited endoscopic signs of presbylarynx. A statistically significant difference was found between presbylarynx versus no presbylarynx concerning diabetes mellitus type 2 (p < 0.001). Subjects with diabetes mellitus type 2 were approximately eight times more likely to have presbylarynx compared to subjects without diabetes mellitus type 2.ConclusionIn this study, 77 per cent of patients with diabetes mellitus type 2 had endoscopic signs of presbylarynx. A multivariable analysis, which took into account co-morbidities of the elderly, identified diabetes mellitus type 2 as a possible risk factor for presbylarynx. Many physiopathological mechanisms might explain this result, as diabetes mellitus type 2 is known to affect muscular, neurological and vascular systems.