bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health Inequalities of Intra-Family Expertise Accessibility: Evidence From China
Authors: Wang Jiwen , Xie Donghong 
Published: May 2021

Abstract
Objectives

To investigate whether unequal exposure to health-related expertise of intra-family is the root of health inequality in China, and to explore the underlying mechanisms through which health-related expertise shapes health outcome.
Methods

In a representative sample of Chinese adults ages over 18 from the 2017 Chinese General Social Survey (CGSS) (n = 3,047 respondents), we use multiple linear regression model and the two-stage least-squares model to analyze the correlation between health-related expertise of intra-family and self-rated health.
Results

The presence of a health professional (HP) in the family is associated with better self-rated health (SRH), and the effect is more important in rural areas than urban areas. An increased chance of exercising appears to explain a part of the association between HP and SRH.
Discussions

Health professionals doing for their family members would have the potential to make a substantial dent in population health and reduce health inequality. Future work will need to understand the patterns of intra-family expertise in health (and other) domains, and the potential replicability of this transmission by public policies.
The Research on Temporal–Spatial Distribution and Morphological Characteristics of Ancient Ruins in Shaanxi Province
Authors: Li Zhengwei 
Published: May 2021

Abstract
This paper uses the spatial analysis method of GIS to study the temporal–spatial distribution characteristics of ancient sites from the Han to the Tang periods in Shaanxi Province. (1) Analysis of topographic features reveals that ancient sites in Shaanxi Province are concentrated in plain areas with slopes due south, east, and southeast, elevations of about 866m, and slopes of 0 to 3°. (2) From the point line analysis, founding the sites are concentrated in the range of 10km, the farther away from the river, the fewer tombs distributed, it shows that the distribution of ancient tombs is linear. (3) The final kernel density analysis found that the site sites from the Han to the Northern and Southern Dynasties were concentrated in the Guanzhong Plain, while the distribution in other areas was more scattered; In the Sui and the Tang Dynasties, the sites were mainly distributed in Guanzhong Plain with Xi'an as the center. Studying the temporal–spatial distribution characteristics of ancient sites can not only explore the relationship between the development of ancient human society and the evolution of the natural environment but also provide a reference for the further study of sites in the future.
Fe@B6H6 Aggregates: From Simple Building Blocks to Graphene Analogue
Authors: Wang Chao , Hou Jianhua , Duan Qian 
Published: May 2021

Abstract
We suggest the possibility to build graphene analogue with the planar hexacoordinate wheel-type Fe@B6H6 cluster as the building block through studying theoretically the geometry, stability and electron structure of its dimer and trimer as well as the dimerization of the two trimers. Employing the dehydrogenation route to polymerization, we can obtain the hexagonal boron sheet that are partly and uniformly filled by Fe atoms in the center of the holes, achieving uniform chemical doping and a very large hexagonal-hole-density. Thus, we may offer a novel cluster-assembled material for experimental chemists to construct graphene analogue.
Mutant MEG3 Enhances the Activity of Telomerase by Increasing DNA Damage Repair in Human Liver Cancer Stem Cells
Authors: Song Shuting , Xie Sijie , Qin Rushi , Lu Yanan , Wang Liyan , Chen Yingjie , Jiang Xiaoxue , Lu Dongdong 
Published: May 2021

Abstract
Background: Long noncoding RNAs have recently considered as central regulators in diverse biological processes and emerged as vital players controlling tumorigenesis. Although wild MEG3 acts as a suppressor in several cancers, the function of mutant MEG3 is also unclear during tumorigenesis.Methods: Lentivalus infection,RT-PCR,Western blotting and tumorigenesis test in vitro and in vivo were performed.Results: our results suggest that mutant MEG3 promotes the growth of human liver cancer stem cells in vivo and in vitro.Mechanistically, our results show that mutant MEG3 enhances acetylation modification of HistoneH4 on K16.Then, mutant MEG3 enhances the expression of SETD2 dependent on H4K16Ac.Moreover, mutant MEG3 increases the DNA damage repair through SETD2.Ultimately, mutant MEG3 increases the telomeras activity dependent on DNA damage repair.Strikingly,TERT determines the cancerous function of mutant MEG3 in liver cancer stem cells. Therefore, we shed light on the fact that targeting mutant MEG3 could be a viable approach for cancer treatment.Conclusions: these observations will play an important role in finding effective tumor treatment targets.
Pregnancy with Atypical Pulmonary Tuberculosis During the COVID-19 Outbreak: A Case Report
Authors: ZHANG Ai-Ping , Liang Manman , Wang Zijian , Hou Weishun , Yang Jianghua 
Published: May 2021

Abstract
Background: During pregnancy, due to reduced immunological resistance, the probability of tuberculosis infection is increased, easily leading to the occurrence of tuberculosis; thus, pregnancy with tuberculosis is a risk to the health of pregnant women with infectious diseases. However, the clinical symptoms of pregnancy with pulmonary tuberculosis are atypical, often confused with the physiological reactions of pregnancy, and there is a lack of clinical awareness, especially in the context of the global COVID-19 pandemic. Specifically, atypical lung lesions are prone to misdiagnosis or delayed diagnosis.Case presentation: A 21-year-old woman was infected with Mycobacterium tuberculosis during the third trimester of pregnancy. The diagnosis and treatment of the patient are reported.Conclusion: The interaction between tuberculosis and pregnancy is a double-edged sword. Increasing awareness of tuberculosis among doctors is essential, and early diagnosis and standardized treatment are key to improving the outcome of pregnancy.
Cranial Venous Outflow Obstruction Promotes Neuroinflammation And Edema Via ADAM17/solTNF-α/NF-κB Pathway In A Rat Subdural Hematoma Model
Authors: Wang Cheng , Xian Liang , Zheng Shaorui , Fang Yi , Lin Kunzhe , Zeng Zihuan , Li Jun , Wang Shousen , Chen Xiangrong 
Published: May 2021

Abstract
Background: Traumatic brain injury (TBI) is recognized as a common cause of death and disability worldwide. Cerebrovascular reaction, as an important cause of secondary injury, can cause secondary bleeding, venous sinus thrombosis, and malignant brain swelling. Intracranial venous return disorder is closely related to patient prognosis. Treatment strategies after craniocerebral injury have primarily focused on the recanalization of cerebral arteries and capillaries and the protection of insulted neurons. In this study, we used an acute subdural hematoma (ASDH) model with cranial venous outflow obstruction (CVO) to explore the mechanism by which CVO aggravates the pathological process after TBI, especially for inflammation and tissue damage.Methods: Based on a rat ASDH model using the modified Miller method, an intracranial venous circulation obstruction intervention was given to form a compound model. A sham operation group (sham), a CVO group, an ASDH group and an ASDH+CVO group were constructed. A neurobehavioural assessment and the determination of brain water content were performed. The content was determined by Evans blue staining. Expression levels of inflammatory factors and metalloproteinases ADAM17 and MMP9 were detected by immunofluorescence assay, ELISA and Western blot. The rats in the ASDH+CVO group were treated with XPro1595 to compare the changes in the NF-κB/MMP9 pathway before and after the inhibition of solTNF.Results: CVO aggravated neurological function defects and damage to the blood-brain barrier in ASDH rats. CVO significantly increased the expression level of ADAM17, and localization of ADAM17 in intracranial cells occurred mainly in microglia or macrophages (positive for IBA-1), accompanied by increased secretion of solTNF. Activation of the ADAM17/solTNF/NF-κB pathway increased the subsequent inflammatory response and tissue damage.Conclusions: The results of this study suggest that intracranial venous return disorder after TBI significantly promotes the expression of ADAM17, which is mainly located in microglia or macrophages, and that the secretion of solTNF-α is increased. The ADAM17/solTNF-α/NF-κB pathway plays an important role in the subsequent inflammatory response and tissue injury. Our study reveals a molecular basis for the finding that CVO aggravates inflammation and tissue damage.
Exploration, Collection and Characterization of Kala zeera (Bunium persicum Boiss. Fedtsch.) Germplasm from North-Western Himalayas
Authors: Khan Mohd Anwar , Altaf Suhail , Shafi Safoora , Bhat Bilal Ahmad , Dar Waseem Ali , Parry Feroz Ahmad , Mir Reyazul rouf 
Published: May 2021

Abstract
Kala zeera (Bunium persicum Boiss. Fedtsch.) is one of the most important spice crop in the world. A set of two hundred fifty two (252) diverse kala zeera germplasm accessions were collected during an exploration mission from hot-spot regions /hills dividing two neighboring countries (India-Pakistan) on line of control (LOC) and hills near line of actual control (LAC) with China. The crop grows wild in its natural habitat mainly in Gurez valley, Tulail, Kashtiwar, Keran, Machil Tangdhar, Machil, Drass, Paddar, Khrew, Char-e-Sharief, Pang, Lahaul spiti, Shaung, Bharmour and Almora hills of Indian Western Himalayas. The germplasm collected has been characterized for morpho-agronomic traits and the analysis of trait data revealed significant variability in number of branches plant-1, number of umbelets umbel-1, number of seeds plant-1, seed yield per plant and 1000 seed weight. The collection and characterization of 252 Kala zeera germplasm accessions can prove useful in future Kala zeera improvement programs in the world as this is first such comprehensive report of the crop from Western Himalayan region of India.
Comparison of Emergency Resection, Self-Expanding Metallic Stents and Decompressing Stoma for Left-Sided Obstructive Colon Cancer: A Protocol for Systematic Review and Network Meta-Analysis
Authors: Hu Qiancheng , Wang Qingfeng , Tan Sirui , Huang Qiyue , Wang Xin , Gou Hongfeng 
Published: May 2021

Abstract
Background: The optimal management strategy for patients with left-sided obstructive colon cancer remains unclear. The aim of this study is to compare the efficacy and safety of emergency resection (ER), self-expanding metallic stents (SEMS) and decompressing stoma (DS) for left-sided obstructive colon cancer.Methods: Electronic searches by titles/abstracts of ER, SEMS and DS for left-sided obstructive colon cancer will be performed using the following electronic bibliographic databases: PubMed, Cochrane Library, Embase and clinical trials. The protocol of this network meta-analysis has been registered on PROSPERO (CRD42021243097). The primary outcomes are the oncological outcomes such as local recurrence rate and overall and disease-free survival. Secondary outcomes of this study include peri- and postoperative outcomes, successful primary anastomosis, temporal and permanent stoma. Included randomized controlled trials will be evaluated on their risk of bias with the Cochrane Collaboration’s risk of bias tool. The quality of observation studies will be assessed using Risk Of Bias In Non-Randomized Studies of Interventions (ROBINS-I) tool. The overall quality of the evidence will be judged based on Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) criteria in the network meta-analysis. Heterogeneity, publication bias, subgroup analysis and sensitivity analysis will be explored.Discussion: Considering the importance of acute intestinal obstruction in left-sided colon cancer, we hope that this network meta-analysis can aid and accelerate the consolidation of evidence, such that health-care professionals and patients are provided with high-quality evidence to facilitate decisions on how to manage patients with left-sided obstructive colon cancer. We will conduct subgroup and sensitive analysis to determine the potentially appropriate population for either ER or a bridge to surgery (SEMS or DS) and provide a foundation for future studies from our network meta-analysis.
Efficacy Comparison and Safety Analysis of Radical Resection of Sigmoid Colon Cancer Based on Different Cancer Locations
Authors: Chen Li , Chen Engeng , Jin Dongai , Chen Min , Zhou Wei , Song Zhangfa 
Published: May 2021

Abstract
Background: Sigmoid colon cancer is a common type of colon cancer; it refers to tumor lesions occurring in the segment approximately 16 cm to 50 cm from the anal margin. Currently, surgical resection is the most effective treatment for non-metastatic sigmoid colon cancer. Therefore, to more accurately standardize colon cancer surgery, we classified the sigmoid colon into distal and proximal segments. This study compares and analyzes the intraoperative situation, postoperative pathology and safety of radical resection of sigmoid cancer in different locations from different aspects. Result: The patients with sigmoid colon tumor can be divided into distal group (16-30cm from the anus) and proximal group (31-50cm from the anus) according to the distance between the tumor and the anal margin. Conclusion: The patients in the distal group using stapler for intestinal anastomosis and anal decompression tube were significantly more than those in the proximal group. For the ligation of the inferior mesenteric artery, high ligation was usually used or the left colic artery was usually preserved in the distal group, and the superior rectal artery was usually retained in the proximal group. The incidence of postoperative complications in the distal group was higher than that in the proximal group, but there was no significant difference between the two groups.
Meta-analysis on the Impact of Positive Psychological Resources on Quality of Life in Cancer Patients
Authors: Zhao Xinxin , Tong Siqi , Yang Ye 
Published: May 2021

Abstract
Purpose: The main purpose of this study was to assess the evidence of the association between positive psychological resources and quality of life among cancer patients. Methods: Electronic search was performed to retrieve articles from PubMed, Web of Science, CNKI and CBM (from inception to November 10, 2020). Summary correlation coefficient (r) values were extracted from each study, and 95% confidence intervals (95%CIs) were calculated by random-effect model. Subgroup and sensitivity analyses were performed to investigate potential heterogeneity.Results: Forty-three articles were included in the present study. The pooled r for resilience was 0.52 (95%CI: 0.43, 0.62), hope 0.50 (95%CI: 0.44, 0.56), self-efficacy 0.54 (95%CI: 0.41, 0.63), self-esteem 0.45 (95%CI: 0.26, 0.64) and optimism 0.32 (95%CI: 0.17, 0.46). For subgroup analysis, the effects of hope and resilience varied with patients’ age.Conclusion: Our study indicated that cancer patients with high level of positive psychological resources tend to live a better quality of life. Therefore, interventions programs based on difference in age for cancer patients could be developed by increasing positive psychological resources in the future research.
Implementation Research for the Evaluation of the Child Health Education and Surveillance Tool Application
Authors: Westgard Christopher M 
Published: May 2021

Abstract
Community health agent programs and modern information and communication technology can greatly improve knowledge of healthy childrearing practices by caregivers in low resource settings, if implemented effectively. Improved knowledge by caregivers can lead to better sanitation, diet, and child development practices. A digital health tool (CHEST App) was developed and deployed in a community health agent program in the Amazon of Peru to improve community health agent performance and ultimately improve early childhood development in the communities. This study presents the results of and evaluation of the implementation and clinical outcomes of the program. METHODS The CHEST App intervention was evaluated using a Hybrid Type II evaluation study design. The effectiveness of the intervention was determined by conducted a paired t-test analysis to compare the mean differences in knowledge scores, hemoglobin levels, early childhood development (ECD) scores, and incidence of diarrhea. The evaluation of the implementation outcomes was conducted with a mixed method approach to identify the extent to which the intervention was successfully installed into the local CHA program. The results of the study are presented within the framework of the Implementation Research Logic Model. RESULTS The CHEST App intervention is associated with improvements in knowledge scores, hemoglobin levels, ECD scores, and decreased diarrhea. However, the evaluation could not isolate the effect of the intervention due to reduction in sample size from COVID-19 closures. The implementation of the CHEST App intervention was effective with high degrees of acceptability, adoption, and fidelity. Adoption and fidelity of the surveillance function of the CHEST App by program coordinators was not achieved. CONCLUSION The CHEST App intervention is a promising tool to improve the performance of CHAs during their home visits, to accomplish their objective of teaching caregivers healthy childrearing practices and improving child health and development in their communities. Trial Registration Trial registered on 11/29/2018 at ISRCTN43591826.
Factors Predicting Failure of Internal Fixations of Fractures of the Lower Limbs: a Prospective Cohort Study
Authors: Prediger Barbara , Tjardes Thorsten , Probst Christian , Parvaresch Anahieta , Glatt Angelina , Anjos Dominique Rodil , Bouillon Bertil , Mathes Tim 
Published: May 2021

Abstract
BackgroundWe assessed predictive factors of patients with fractures of the lower extremities caused by trauma. We examined which factors might increase failure rates. Furthermore, the predictive factors were set into context with other long-term outcomes, concrete pain and physical functioning.MethodsWe performed a prospective cohort study at a single level I trauma center. We enrolled patients with traumatic fractures of the lower extremities treated with internal fixation from April 2017 to July 2018. We evaluated the following predictive factors: age, gender, diabetes, smoking status, obesity, open fractures and peripheral arterial diseases. The primary outcome was time to failure (nonunion, implant failure or reposition), secondary outcomes were pain and physical functioning measured at follow up 6 months after initial surgery. For the analysis of the primary outcome we used a multivariate stratified (according fracture location) Cox proportional hazard regression model.Results We included 204 patients. Overall, we observed a failure in 33 patients (16.2%). Most of the failures occurred within the first 3 months. Obesity and open fractures increased the risk of failure and decreased physical functioning. None of the predictors had an impact on pain. Age, female gender and smoking of more than ≥ 10 package years increased failure risk numerically but statistical uncertainty was high.Conclusion We found that obesity and open fractures strongly increased the risk of failure. These seem promising candidates to be included in a risk prediction model and can be considered as a good start for clinical decision making across different types of fractures in the lower limb. However, large heterogeneity in the other analyzed factors suggest that for a precise personalized risk estimation, computer-based models incorporating a variety of detailed information (e.g. pattern of injury, x-ray and clinical data) and their interrelation might be needed to increase precision of prediction significantly.Trial registrationNCT03091114
Do Health Sector Measures of Violence against Women at Different Levels of Severity Correlate? Evidence from Brazil
Authors: Reynolds Sarah Anne 
Published: May 2021

Abstract
OBJECTIVE To evaluate if characteristics of reports of violence against women at different levels of severity are similar and to test if their prevalence is correlated at the municipal level. METHODS I use data from women ages 15-49 who were killed by homicide in Brazil’s national death registry (N=14,373), were hospitalized for aggression (N=14,701), or were included in the medical mandatory reports of incidents of violence against women (N=42,134) between 2011 and 2016 in select municipalities. I provide national level descriptive statistics from 2016 contrasting distributions of victims (age, education, and race) and distributions of the characteristics of the incidents (location and time of day). Then, for 63 municipalities with a high number of violent incidents, I calculate the correlation coefficients between measures of violence against women using quarterly data from 2011-2016. I use multiple regression of municipal characteristics at baseline to examine which factors (poverty, spending, health, and civic engagement) predict the correlation. RESULTS Victim characteristics and incident characteristics are similar across the measures of violence at the national level. Despite these aggregate similarities, correlations at the municipal level are quite varied, ranging from -0.69-0.83. I find no municipal characteristics that consistently predict these correlation coefficients.CONCLUSIONS Despite some similarities at an aggregate level, these measures of violence against women do not have consistent patterns of correlation at the municipality level. Measures of severe levels of violence against women are not good proxies for incidence of violence at less severe physical levels. Lack of correlations could be due to differences in reporting, but may also be due to differences in underlying processes that share similar victims and event characteristics.