bluuebunny/crossref_metadata_2025_split huggingface dataset:
17-Year Follow-Up of Comparing Mastoscopic and Conventional Axillary Dissection in Breast Cancer: A Multicentres, Randomized Controlled Trial
Authors: Luo， Chengyu , Cao Guang , Guo Wenbin , Yang Jie , Sun Qiuru , Wei Wei , Wu Shuhua , Fang Shubin , Zeng Qingliang , Zhao Zhensheng , Meng Fanjie , Huang Xuandong , Zhang Xianlan , Li Ruihua , Ma Xiufeng , Luo Chaoying , Yang Yun 
Published: September 2021

Abstract
Background: Longer follow-up was necessary to testify the exact value of mastoscopic axillary lymph node dissection (MALND).Methods：From January 1, 2003 to December 31, 2005, 1027 patients with breast cancer were randomly assigned to two groups: MALND and CALND (conventional axillary lymph node dissection). 996 eligible patients were enrolled.Results：The final cohort of 996 patients was followed for an average of 198 months. The events other than death differed significantly between the two cohorts（p=0.0311） (46.3% in MALND and 53.2% in CALND, respectively). The sum of the events other than death and deaths from other causes was much more in CALND （59.6%）than in MALND (53.4%）（p=0.0494）. The 17-year DFS rates were 36.7 percent for MALND group and 33.6 percent for CALND group，respectively. There was a signiﬁcant difference between the groups (p=.0306). The OS rates were 53.2 percent after MALND and 46.0 percent after CALND ( p= .0119). The MALND patients had much less axillary pain (p =. 0000), numbness or paresthesia (p = .0000) ，arm mobility (p =. 0000), and arm swelling on operated side (p = .0000). The aesthetic appearance of axilla in MALND group was much better than that in CALND group (p =. 0000) at an average follow-up of 17-year.Conclusions：The use of MALND in breast cancer surgery not only decreases the relapse and arm complications but also improves long-term survival of patients. Therefore, MALND should be one of the preferred approaches for breast cancer surgery when ALND is needed.
Relationship between fibrinogen/albumin ratio and early renal damage markers in patients with hypertension
Authors: dong jiankai jian , Zhang Yaping 
Published: September 2021

Abstract
Aim:To investigate the relationship between fibrinogen/albumin ratio (FAR) and early renal damage in hypertensive patients.Patients & methods:A retrospective study included 626 patients with hypertension, grouped according to the FAR tertiles and the presence or absence of early renal impairment. Early renal damage indicators[Serum cystatin c and β2 microglobulin] were detected in each group, and the differences between groups were compared, and the factors affecting early renal damage indicators were analyzed.Results:Serum cystatin c(CysC) and β2 microglobulin(β2-MG) levels in patients increased with FAR. In the renal impairment group, the fibrinogen and FAR were significantly increased, and serum albumin was decreased. FAR was positively correlated with β2-MG and CysC. Regression analysis showed that FAR level was a factor affecting blood β2-MG(β=6.632, p＜0.001)and CysC(β=1.991, p＜0.001).Conclusion:Elevated FAR is an independent risk factor for early renal damage in hypertensive patients
Role of NRF2 cascade in determining the differential response of cervical cancer cells to anticancer drugs- an in vitro study
Authors: Ramesh Pushkal Sinduvadi , Raja Sharanya , Udayakumar Shwethambari Harave , Chandrashekar Shruthi , Nataraj Suma M , Devegowda Devananda 
Published: September 2021

Abstract
Background
Cervical cancers are usually treatable if detected in early stages by a combination of therapies. However, the prognosis of cervical cancer patients with metastasis remains unfavorable due to the fact that most of the cervical carcinomas are either resistant to anticancer drugs or show signs of relapse after initial treatment. Therefore, it is important to control the chemoresistance as it is the key to develop effective treatment options for cervical cancer.
Objective
The current study aimed at evaluating the differential responses of cervical cancer cells to anti-cancer drugs and assessed whether the differences in the expression profiles of antioxidant genes regulated by NRF2 (nuclear factor erythroid-2-related factor 2), led to the variations in the sensitivities of the cancer cells to treatment. Methodology: Three cervical cancer cell lines were investigated for their differences in NRF2 pathway by measuring the gene expression and enzyme activity. The differences in the sensitivity to anti-cancer drugs and variation in ROS profile was also evaluated. The addition of exogenous drugs to manipulate the intracellular ROS and its effect on NRF2 pathway genes was also investigated.
Results
HeLa and SiHa cells were more sensitive to cisplatin and oxaliplatin treatment than C33A cells. HeLa and SiHa cells had significantly lower NRF2 gene levels, NQO1 enzyme activity and basal GSH levels than C33A cells. Levels of ROS induced were higher in HeLa than C33A cells.
Conclusion
Overall, the differences in the cellular levels of antioxidant regulatory genes led to the differential response of cervical cancer cells to anti-cancer drugs.
Pregnancy and Obstetric Outcomes of Dichorionic and Trichorionic Triamniotic Triplet Pregnancy with Multifetal Pregnancy Reduction: A Retrospective Analysis Study
Authors: Liu Shuhua , Li Guanjian , Wang Chao , Chen Xianxia , Zhou Ping , Song Bing , Wei Zhaolian 
Published: September 2021

Abstract
Background: It is generally beneficial for triplet gestation or high-order multiple pregnancies to operate multifetal pregnancy reduction (MFPR) after assisted reproductive techniques. However, data on pregnancy outcomes is lacking regarding dichorionic triamniotic (DCTA) and trichorionic triplets (TCTA) pregnancy.Method: This research analyzes the difference between 128 DCTA and 179 TCTA pregnancies with or without MFPR after in vitro fertilization/intracytoplasmic sperm injection cycles between January 2015 and June 2020. The subdivided subgroups of the two groups are reduction to singleton, reduction to dichorionic twins, and anticipation management groups. We also compare the pregnancy and obstetric outcomes between 2104 dichorionic twins and 122 monochorionic twins.Result: The research subgroups were DCTA to monochorionic singleton pregnancies (n=76), DCTA to dichorionic twin pregnancies (n=18), DCTA-anticipation management (n=34), TCTA to monochorionic singleton pregnancies (n=31), TCTA to dichorionic twin pregnancies (n=130), and TCTA-anticipation management (n=18). In DCTA-anticipation management group, the complete miscarriage rate is dramatically higher, and the survival rate and the rate of take-home babies are lower. However, there was no difference between the rates of complete miscarriages, survival rates, and take-home babies in TCTA-anticipation management group. But the complete miscarriage rate of DCTA-anticipation management was obviously higher than that of TCTA-anticipation management group (29.41 vs. 5.56%, p=0.044). For obstetric outcomes, MFPR to singleton group had higher gestational week and average birth weight, but lower premature delivery, gestational hypertension rates and low birth weight in both DCTA and TCTA pregnancy groups (all p<0.05). Monochorionic twins have higher rates of complete, early, and late miscarriage, premature delivery, and late premature delivery, and lower survival rate and twin survival rate rates (p<0.05).Conclusion: MFPR could improve gestational week and average birth weight, reducing premature delivery, LBW, and gestational hypertension rates in DCTA and TCTA pregnancies. Monochorionic twins have worse pregnancy and obstetric outcomes. MFPR to singleton is preferable recommended in the pregnancy and obstetric management of complex triplets with monochorionic pair.
The Impact of Delays During the Pandemic Months on Survival of Lung Cancer Patients in Canada in 2020.
Authors: Khandelwal Luv , Begum Housne , Nippak Pria 
Published: September 2021

Abstract
Objective

Most cancer deaths in the world are due to lung cancer and delays in diagnosis and treatment sharply reduce survival in lung cancer patients. This study examined the impact of delays during the early months of the pandemic on the survival of newly identified lung cancer patients in Canada in 2020.
Methods

The incidence of lung cancer, using population statistics from Statistics Canada and incidence rates from the Canadian Cancer Statistics in 2020, was estimated. Stage-wise incidences for each sex were calculated for each age group for each month of 2020. Using delay impact on each stage the final results were calculated.
Results

A total of 5,004 life years would have been lost due to 448 deaths in the long term (40 months) attributed to the delays caused during March, April, May and June in Canada. The estimated incidence for all stages of lung cancer for these months was 9,801 although the observed incidence was expected to be 6,571 due to reduced screenings. Hence, it was within the missing 3,231 cases that delays would occur. Over the short term (10 months) there are expected to be 151 early deaths and 273 deaths in the intermediate-term (20 months).
Conclusion

The COVID pandemic is estimated to result in increased mortality and fewer diagnosis’ of lung cancer patients in Canada in 2020.
Identification of MicroRNA-mRNA Regulatory Networks in Periodontitis by Bioinformatics Analysis
Authors: Gao Xiaoli , Zhao Dong , Wang Zuomin , Zhang Zheng , Han Jing 
Published: September 2021

Abstract
Background: Periodontitis is a complex infectious disease with various causes and contributing factors. In recent years, microRNAs (miRNAs) have been commonly accepted as having key regulatory functions in periodontal disease. The aim of this study was to identify miRNAs and hub genes involved in periodontal disease pathogenesis using a miRNA-mRNA interaction network.Methods: The GSE54710 miRNA microarray dataset and the gene expression microarray dataset GSE16134 were downloaded from the Gene Expression Omnibus database. The differentially expressed miRNAs (DEMis) and mRNAs (DEMs) were screened using P <0.05 and |log FC| ≥1. Potential upstream transcription factors and downstream target genes of candidate DEMis were predicted using the FunRich and miRNet programs, respectively. Subsequently, DEMs were uploaded to the STRING database, a protein-protein interaction (PPI) network was established, and the cytoHubba plugin was used to screen out key hub mRNAs. The key genes in the miRNA-mRNA regulatory network were extracted by intersecting the target genes of candidate DEMis and DEMs. Cytoscape software was used to visualise the interaction between miRNAs and mRNAs and to predict the hub genes. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were used to analyse the key genes in the regulatory network.Results: Ten DEMis and 161 DEMs were filtered out, from which we constructed a miRNA-mRNA network consisting of six miRNAs and 32 mRNAs. KEGG pathway analysis showed that mRNAs in the regulatory network were mainly involved in the IL-17 signalling pathway. Hsa-miR-203/CXCL8, hsa-miR-203/BTG2, and hsa-miR-203/DNAJB9 were identified as four potential regulatory pathways for periodontitis. Conclusion: In this study, a potential miRNA–mRNA regulatory network was first constructed and four regulatory pathways were identified for periodontitis to help clarify the aetiology of the disease and provide potential therapeutic targets.
Effects of Micronized Bamboo Powder on Growth Performance, Serum Biochemical Indexes, Cecal Chyme Microflora and Metabolism of Broilers Aged 1-22 Days
Authors: Dai Fawen , Lin Tao , Cheng Lumin , Wang Jian , Zuo Jianjun , Feng Dingyuan 
Published: September 2021

Abstract
Necrotic enteritis is common in broilers, which makes negative effects on growth performance. Adding insoluble fiber to diet of broilers has been reported to improve intestinal health and promote growth performance. Bamboo powder is a cheap raw material with rich insoluble fiber. This study aims to explore the effects of feeding micronized bamboo powder (MBP) on growth performance, serum biochemical indexes, intestinal microflora, and metabolism of broilers. A total of 1440 1-day-old ephedra chickens were randomly divided into three groups considering gender and body weight: (1) Group D: feeding with basal diet without antibiotics; (2) Group E: feeding with basal diet supplemented with 5% rice bran (RB); (3) Group F: feeding with basal diet supplemented with 1% MBP. Each group involved 8 replicates, with 60 chickens per replicate. After feeding for 22 days, various indexes were detected. For the growth performance, the weight gain and feed consumption ratio (G: F) of Group F supplemented with MBP is 0.57 ± 0.04, which is significantly higher than that of E group supplemented with RB (0.52 ± 0.01, P < 0.05). For the serum biochemical indexes, the glutathione peroxidase activity in Group F is significantly higher than that of in Group D, while the malondialdehyde content is significantly lower than that of in Group D and Group E (P < 0.05 for all). The fresh cecal chyme is taken for determination. In Group F, the α diversity index Faith_pd is significantly lower in Group F than that of in Group D. The microorganism species in cecal chyme of Group F and Group E are also different. The metabolic pathways of Group F differ from those of Group D and Group E, mainly manifested in fatty acid metabolism, amino acid metabolism and intestinal immune IgA production. Adding 1% MBP to broiler diet can enhance the anti-oxidant capacity, improve chyme microflora, regulate the metabolism pathways responsible for intestinal fatty acids, amino acids, and immunity.
The Relationship Between Brain Natriuretic Peptide (NT-proBNP) Levels and Diastolic Heart Failure in Patients With COVID-19
Authors: Ziaie Naghmeh , Ezoji Khadijeh , Ziaei Seyedeh Golnaz , Chehrazi Mohammad , Maleh Parviz Amri , Pourkia Roghayeh , Seyfi Shahram 
Published: September 2021

Abstract
Background: Diastolic dysfunction has been reported in patients with COVID-19. Due to the role of N-terminal pro-brain natriuretic peptide (NT-proBNP) in the diagnosis of heart failure, this study investigated the relationship between serum NT-proBNP levels and diastolic heart failure in COVID-19 patients.Methods: This descriptive-analytical study was performed at Ayatollah Rouhani Hospital in Babol. Fifty-four patients with confirmed COVID-19 diagnosis who were admitted to the ICU were included in the study. The primary outcome was the relationship and predictive role of NT-proBNP and diastolic heart failure in patients with severe SARS-COV-2 infection. Patients with pro BNP >125 pg/mL underwent echocardiography and the relationship between echocardiographic indices and NT-proBNP was assessed as a secondary outcome.Results: Our study showed that plasma NT-proBNP levels in patients with increased diastolic dysfunction were associated with disease severity. It was also found that the cut-off point of NT-proBNP = 799 pg/mL could be a predictor of diastolic dysfunction grades two and three. In this study, patients with a serum NT-proBNP level equal or above 799 had 37 times higher chance of having diastolic dysfunction than those with a serum NT-proBNP level below 799. Patients with NT-proBNP above 556 had RV_EA> 2 in echocardiography, indicating increased right-sided filling pressures.Conclusion: Despite the confounding factors in the interpretation of the pro BNP level in COVID-19, its level can be used to estimate the presence of high-grade diastolic heart failure on the left and right sides of the heart and the presence of high filling pressures. Lower levels of NT-proBNP are associated with right-sided diastolic failure.
What do Biphasic Flow Experiments Reveal On the Variability of Exposure on Alluvial Fans and Which Implications for Risk Assessment Result From This?
Authors: Diaz Hector , Mazzorana Bruno , Gems Bernhard , Rojas Ivan , Santibañez Nicole , Iribarren Pablo , Pino Mario , Iroumé Andres 
Published: September 2021

Abstract
Autogenic processes, such as sudden avulsions, unexpected channel migrations and backfilling phenomena, can considerably alter the propagation of sediment-laden flows on alluvial fans. Once the initial and boundary conditions of the hazard scenario with a given return period are determined, the delineation of the associated exposed areas is based on one numerical, essentially deterministic, process simulation, which may not adequately reflect the underlying process variability. By following a ‘similarity-of-process concept’ we generated sediment-laden flows on an experimental alluvial fan. Thereby, we considered an alluvial fan model layout with a curved guiding channel and featuring a convex shape. As loading conditions, we defined a reference, an increased and a reduced level for the released water volume and the predisposed solid fraction. Further, we imposed two different stream power regimes and executed, for each factor combination, eight experimental runs. The associated exposure areas were recorded by video and were mapped in a GIS. We then analyzed exposure data and derived exposure probability maps superposing the footprints of the eight repetitions generated by each experimental loading condition. The patterns of exposure associated with specific loading conditions showed a noticeable variability due to the main effect of the total event volume, the solid fraction and the interactions between them and with the imposed stream power in the feeding channel. Our research highlights that a probabilistic notion of exposure in risk assessment and mitigation needs to be considered. Further, a major challenge consists in adapting numerical codes to better mirror the stochastics of process propagation for more reliable flood hazard and risk assessments.
Development and Evaluation of Video-Based Educational Materials for Nutritional Management of Cancer in Children Among Healthcare Professionals and Caregivers
Authors: Razalli Nurul Huda , Alias Hamidah , Mohammad Mohd Hafizuddin , Rahim Nur Ruzaireena , Zulkipli Nur Qharena Alwani 
Published: September 2021

Abstract
Background A good audio-visual educational material for caregivers on nutrition management of pediatric oncology patients can improve treatment effectiveness, recovery rate, and nutritional status of patients. This study aimed to develop and evaluate a series of video-based educational materials for nutritional management of pediatric oncology patients among healthcare professionals and caregivers.Methods The development of the video series began with subtopic selection and content refinement based on a printed booklet project previously published by the groups of five experts in dietetics and oncology medicine and five caregivers of pediatric cancer patients. 10 healthcare professionals (medical doctors and dietitians with over 5 years of working experience) and 15 caregivers then evaluated the video series for acceptability and relevance using the Malay version of the Patient Education Materials Assessment Tools for Audio-Visual materials (PEMAT-AV). Sets of understandability and actionability statements were given a score of 0 (disagree) or 1 (agree), and the overall percentage was calculated.ResultFour main topics were selected from the booklet and adopted into 5 video series ranging from 3 to 8 minutes in length developed in the Malay language entitled (i) Introduction to Cancer and the Treatment, (ii) The Side Effects of Cancer Treatment and Management (Part 1), (iii) The Side Effects of Cancer Treatment and Management (Part 2), (iv) Nutrition Management in Children with Cancer, and (v) You Ask, We Answer. The average understandability and actionability scores rated by the healthcare professionals were 98.6%% and 98.7%respectively. Whereas the caregivers’ average score for understandability was 99.5% and 99.6% for actionability.ConclusionsThe findings revealed that a high-quality video series was successfully developed and rated as highly understandable and actionable by both healthcare professionals and caregivers. This reflects positive acceptance and relevance of the nutritional management educational videos by both groups who manage and care for pediatric cancer patients. Trial RegistrationCentre for Research and Instrumentation Management, Research Ethics Committee of The National University of Malaysia; Ref. No. UKM/PPI/111/8/JEP-2021-266
Post-Pharmacy Exam - Are We Ready? - The Results of the Exam conducted in Poland on the Model of the UK
Authors: Merks Piotr , Religioni Urszula , Rutkowska Aleksandra , Munzu Marvin , Panford-Quainoo Edwin , Barańska Agnieszka , Waszyk-Nowaczyk Magdalena , Krysiński Jezrzy 
Published: September 2021

Abstract
Background.

This article aims to present the results of the final exam in pharmacy among Polish pharmacy students. This exam was modeled on the British national exam supervised by the General Pharmaceutical Council.
Methods.

The exam was conducted in 3 cities in Poland, among a total of 175 final-year students. Taking the exam was voluntary and anonymous.
Results.

The results indicate that none of the Polish students achieved the 70% mark required to pass the Great Britain exam. Significant differences in test results were noticed between cities. Students achieved the best average exam result in Bydgoszcz (46.35%), then in Warsaw (38.81%) and Łódź (38.35%)
Conclusions.

The pharmaceutical education system in Poland requires complete changes that will prepare future pharmacists for clinical work. Increasing the role of a pharmacist in health care requires raising the level of education and emphasizing the practical content of education.