bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relevance of Germline Mutation Screening in Both Familial and Sporadic Head and Neck Paraganglioma for Early Diagnosis and Clinical Management
Authors: Hermsen Mario A. , Sevilla María A. , Llorente José Luis , Weiss Marjan M. , Grimbergen Anneliese , Allonca Eva , Garcia-Inclán Cristina , Balbín Milagros , Suárez Carlos 
Published: January 2021

Background: Head and neck paraganglioma (PGL) are benign tumors that can cause important direct or surgery induced morbidity. Almost all familial and 11–29% of sporadic PGL are caused by inactivating germline mutations in succinate dehydrogenase (SDH) genes. Our aim was to screen for such mutations and to evaluate clinical parameters as predictors of germline mutation.Methods: Seventy-four PGL patients were analyzed for germline mutations and large deletions in SDH genes, VHL and RET. Results were correlated to clinical characteristics including gender, age, tumor localization and multifocality. The surgical approach was evaluated in terms of tumor origin, sequelae and subsequent evolution.Results: Mutations in SDHB and SDHD were identified in equal proportion in 13/13 (100%) of familial and in 15/61 (25%) of sporadic cases. Familiarity, age ≤50 years and male gender were predictors of any germline mutation, while multifocality and carotid/vagal localization were indicative of SDHD mutation in particular.Conclusions: In contrast to other series, this cohort of Spanish patients showed many SDHB mutations. Sporadic cases with germline mutation are frequent and underline the importance of mutational screening of all PGL patients, allowing the identification of relatives at risk and the early diagnosis of the disease, reducing or avoiding morbidity.
Erectile dysfunction in male lymphoma survivors in a Southeast Asian country
Authors: Gan Gin Gin , Ng Diana Leh Ching , Leong Yuen Chwan 
Published: January 2021

Abstract

Introduction:
Although erectile dysfunction (ED) is one of known long-term complications among male lymphoma survivors, it is not commonly reported, particularly in Southeast Asia. This study aimed to determine the prevalence of ED in lymphoma survivors in Malaysia and its association with anxiety and depression, and effects on quality of life.

Methods:
This was a cross-sectional study conducted at a tertiary hospital in Malaysia. Patients were all male lymphoma survivors. The self-administered International Index of Erectile Function questionnaire was used to screen for ED. The Hospital Anxiety and Depression Score questionnaire was used to assess for anxiety and depression, and quality of life was assessed using the European Organization for Research and Treatment of Cancer quality of life questionnaire.

Results:
Overall, 106 patients were recruited. Mean age was 55.7 years, with 61.3% of patients aged above 50 years. Only 67.0% of patients were sexually active and 81.7% of these reported the presence of ED, with only 4.2% having severe ED. Prevalence of ED among younger patients (age ≤50 years old) was 64.5%.The most common reason given by patients who were not sexually active was fatigue. Age was the only factor found to be associated with ED (p <0.005) and severity of ED increased with age. There was no association between ED and psychological stress or quality of life.

Conclusion:
Prevalence of ED and absence of sexual activity in lymphoma survivors was high. This should serve as a reminder to the treating clinician to offer early treatment and counselling.
One Manuscript, Many Books: The Manuscript and Editing History of Aḥkām ahl al-dhimma
Authors: Bosanquet Antonia 
Published: January 2021

Abstract
Aḥkām ahl al-dhimma is a book of regulations about Christian and Jewish subjects of Islamic rule, written by the Ḥanbalī jurist and theologian Ibn Qayyim al-Jawziyya (d. 751/1350). It is an important resource for historical studies of non-Muslim minorities in the Mamluk period and is often cited as a normative text in present-day Muslim discussions about Muslim-non-Muslim relations. This article gives an insight into the history of the only surviving manuscript of Aḥkām ahl al-dhimma and the unusual process by which the first printed edition was compiled. It shows that the movement of the manuscript was largely a result of Ibn Taymiyya’s and Ibn al-Qayyim’s more general popularity in specific geographic regions than the authority of the text itself, and that individuals’ religious-intellectual interests were decisive for the publication of a printed edition in 1961. It also shows that the unusual editing process impacted on the reliability of the printed editions available today, the majority of which are financed by Saudi institutions.
Inductive Metaphysics
Authors: Engelhard Kristina , Feldbacher-Escamilla Christian J. , Gebharter Alexander , Seide Ansgar 
Published: January 2021

Abstract
This introduction consists of two parts. In the first part, the special issue editors introduce inductive metaphysics from a historical as well as from a systematic point of view and discuss what distinguishes it from other modern approaches to metaphysics. In the second part, they give a brief summary of the individual articles in this special issue.
Analogical Inference in Gustav Theodor Fechner’s Inductive Metaphysics
Authors: Seide Ansgar 
Published: January 2021

Abstract
Gustav Theodor Fechner was one of the main proponents of inductive metaphysics in the 19th century. The idea of inductive metaphysics is to use empirical sources and inductive forms of inference in metaphysics. Although this sounds like a research program which might well appeal to scientifically minded philosophers, some of Fechner’s metaphysical conclusions look very suspicious from a scientific viewpoint. For example, Fechner famously argues that the planets and stars are animated by a soul and that the same holds for the whole universe. In the present article it is shown that Fechner’s mystical cosmological views are based on a principle of analogy which is too permissive and that as a result of that his central argument to the conclusion that the earth is animated by a soul is not correct. As the article argues, the principle Fechner bases his inference on has to be supplemented by a causal condition along the lines of Mary Hesse’s account of analogical inferences, a condition Fechner at least implicitly recognizes but fails to meet.
Adsorption behaviour of clomazone on inorganic and organically modified natural montmorillonite from Bogovina (Serbia)
Authors: Kaluđerović Lazar , Tomić Zorica P. , Đurović-Pejčev Rada , Životić Ljubomir 
Published: January 2021

AbstractThe adsorption behaviour of the herbicide clomazone on inorganic and organically modified montmorillonite from the Bogovina deposit in Serbia was investigated. Montmorillonite was modified first with NaCl and then with organic complexes such as hexadecyltrimethylammonium bromide (HDTMA) and phenyltrimethylammonium chloride (PTMA). Changes in the surface properties and morphology of the montmorillonite before and after the modification with various concentrations of organic complexes were investigated using X-ray diffraction (XRD) and scanning electron microscopy (SEM). Adsorption of clomazone on all examined samples was investigated using the batch adsorption method. Montmorillonite modified with HDTMA-bromide displayed greater uptake of the clomazone compared to the PTMA-montmorillonite, and both organically modified montmorillonites displayed greater uptake of the herbicide compared to the inorganic montmorillonite. Comparing the Freundlich coefficient and maximum adsorbed clomazone quantity values obtained by Langmuir model, the levels of adsorption of clomazone decreased in the following order: HDTMA-montmorillonite with 1.00 cation-exchange capacity (CEC) saturation > HDTMA-montmorillonite with 0.75 CEC saturation > PTMA-montmorillonite with 1.00 CEC saturation > PTMA-montmorillonite with 0.75 CEC saturation > HDTMA-montmorillonite with 0.50 CEC saturation > HDTMA-montmorillonite with 0.25 CEC saturation > PTMA-montmorillonite with 0.50 CEC saturation > PTMA-montmorillonite with 0.25 CEC saturation > Na-montmorillonite > raw sample. The type and content of an organic cation plays an important role in the behaviour of clomazone in a solid/liquid system. It is concluded that organically modified montmorillonite from Bogovina might be used as an effective adsorbent for clomazone.
The formation of alluvial platinum-group minerals: present knowledge and the way ahead
Authors: Bowles John F.W. , Suárez Saioa 
Published: January 2021

AbstractThe weathering of platinum-group element (PGE) deposits presents unusual problems, especially in the very active environment of lateritic weathering under tropical conditions. There is clear evidence of the destruction of platinum-group minerals (PGM) to form PGE oxides, or fine intergrowths between relict PGM and iron oxides or hydroxides, as an intermediate stage during weathering. The PGE released by weathering are transported in solution with the more soluble Pd species remaining in solution and travelling further than the less soluble Pt species. The presence of PGM in the laterite differing in mineralogy, mineral assemblage and size from those in the primary rock is difficult to explain, especially when they show secondary textures. Differing interpretations have created controversy. Are alluvial PGM derived unaltered from the primary rock where they are rare and, therefore, not encountered by standard petrographic examination? Is it possible that they could have developed in the laterite by some process that we do not yet fully understand? Some favourable genetic conditions have been outlined and debated. For more than 100 years authors have reported secondary ore textures and recently proposed a biogenic origin. Frank Reith and his co-workers provided evidence of a process involving metallophillic bacteria which, for the first time, demonstrates PGM growth in the laboratory under supergene conditions. Their work shows that a mechanism for supergene growth (‘neoformation’) can occur, which offers a new field of study of the appropriate Eh, pH, $f_{{\rm O}_ 2}$ conditions and organic and bacterial reactions that could permit supergene growth.
Rapid removal of phagosomal ferroportin in macrophages contributes to nutritional immunity
Authors: Flannagan Ronald S. , Farrell Tayler J. , Trothen Steven M. , Dikeakos Jimmy D. , Heinrichs David E. 
Published: January 2021

Abstract
Nutrient sequestration is an essential facet of host innate immunity. Macrophages play a critical role in controlling iron availability through expression of the iron transport protein ferroportin (FPN), which extrudes iron from the cytoplasm to the extracellular milieu. During phagocytosis, the limiting phagosomal membrane, which derives from the plasmalemma, can be decorated with FPN and, if functional, will move iron from the cytosol into the phagosome lumen. This serves to feed iron to phagocytosed microbes and would be counterproductive to the many other known host mechanisms working to starve microbes of this essential metal. To understand how FPN is regulated during phagocytosis, we expressed FPN as a green fluorescent protein–fusion protein in macrophages and monitored its localization during uptake of various phagocytic targets, including Staphylococcus aureus, Salmonella enterica serovar Typhimurium, human erythrocytes, and immunoglobulin G opsonized latex beads. We find that FPN is rapidly removed, independently of Vps34 and PI(3)P, from early phagosomes and does not follow recycling pathways that regulate transferrin receptor recycling. Live-cell video microscopy showed that FPN movement on the phagosome is dynamic, with punctate and tubular structures forming before FPN is trafficked back to the plasmalemma. N-ethylmaleimide–sensitive factor, which disrupts soluble NSF attachment protein receptor (SNARE)–mediated membrane fusion and trafficking, prevented FPN removal from the phagosome. Our data support the hypothesis that removal of FPN from the limiting phagosomal membrane will, at the cellular level, ensure that iron cannot be pumped into phagosomes. We propose this as yet another mechanism of host nutritional immunity to subvert microbial growth.
Chromosomal defects and survival in patients with adult T-cell leukemia/lymphoma after allogeneic HSCT
Authors: Nakano Nobuaki , Utsunomiya Atae , Matsuo Keitaro , Yoshida Noriaki , Seto Masao , Ohshima Kouichi , Fujiwara Hiroshi , Fuji Shigeo , Takatsuka Yoshifusa , Ito Ayumu , Miyamoto Toshihiro , Suehiro Youko , Nakamae Hirohisa , Sawayama Yasushi , Yuasa Mitsuhiro , Miyazaki Yasuhiko , Ota Shuichi , Imada Kazunori , Fukuda Takahiro , Ichinohe Tatsuo , Atsuta Yoshiko , Kato Koji 
Published: January 2021

AbstractAdult T-cell leukemia/lymphoma (ATL) cells frequently exhibit chromosomal abnormalities, including numerical aberrations and structural defects. However, no studies have examined the correlation between these abnormalities and survival in patients with ATL after allogeneic HSCT (allo-HSCT). In this study, 300 patients with ATL (median age, 55 years; range, 24-74) who were registered in a Japanese nationwide registry database were analyzed. The majority (n = 183) had acute ATL. Specimens for chromosomal analysis were collected from bone marrow (n = 166), lymph nodes (n = 86), peripheral blood (n = 41), and other locations (n = 7). In survival analyses, breakpoints at 2q (hazard ratio [HR], 1.63; 95% confidence interval [CI], 1.12-2.38; P = .012) and 5q (HR, 2.18; 95% CI, 1.25-3.80; P = .006) were significantly poor prognostic factors for overall survival (OS). In terms of ATL-related death, loss of chromosome 14 and breakpoints at 3p, 1q, 5q, and 6q were extracted as significantly poor prognostic factors. Moreover, complex karyotypes were associated with ATL-related death. This study of the survival impact of chromosomal abnormalities in patients with ATL after allo-HSCT demonstrated that several structural breakpoints were independent risk factors for OS and ATL-related death.
Asthma prescribing according to Arg16Gly beta-2 genotype: a randomised trial in adolescents
Authors: Ruffles Tom , Jones Christina J. , Palmer Colin , Turner Steve , Grigg Jonathan , Tavendale Roger , Hogarth Fiona , Rauchhaus Petra , Pilvinyte Kristina , Hannah Romanie , Smith Helen , Littleford Roberta , Lipworth Brian , Mukhopadhyay Somnath 
Published: January 2021

IntroductionThe A allele of rs1042713 (Arg16 amino acid) in the β2-adrenoreceptor is associated with poor response to long-acting β2-agonist (LABA) in young people with asthma. Our aim was to assess whether the prescribing of second-line controller with LABA or a leukotriene receptor antagonist according to Arg16Gly genotype would result in improvements in Pediatric Asthma-Related Quality of Life Questionnaire (PAQLQ).MethodsWe performed a pragmatic randomised controlled trial (RCT)viaa primary care clinical research network covering England and Scotland. We enrolled participants aged 12–18 years with asthma taking inhaled corticosteroids. 241 participants (mean±sdage 14.7±1.91 years) were randomised (1:1) to receive personalised care (genotype directed prescribing) or standard guideline care. Following a 4-week run-in participants were followed for 12 months. The primary outcome measure was change in PAQLQ. Asthma control, asthma exacerbation frequency and healthcare utilisation were secondary outcomes.ResultsGenotype-directed prescribing resulted in an improvement in PAQLQ compared to standard care (0.16, 95% CI 0.00–0.31; p=0.049), although this improvement was below the pre-determined clinical threshold of 0.25. The AA genotype was associated with a larger improvement in PAQLQ with personalisedversusstandard care (0.42, 95% CI 0.02–0.81; p=0.041).ConclusionThis is the first RCT demonstrating that genotype-driven asthma prescribing is associated with a significant improvement in a clinical outcome compared to standard care. Adolescents with the AA homozygous genotype benefited most. The potential role of such β2-adrenoceptor genotype directed therapy in younger and more severe childhood asthma warrants further exploration.
Oesophageal pressure as a surrogate of pleural pressure in mechanically ventilated patients
Authors: Tilmont Antoine , Coiffard Benjamin , Yoshida Takeshi , Daviet Florence , Baumstarck Karine , Brioude Geoffrey , Hraiech Sami , Forel Jean-Marie , Roch Antoine , Brochard Laurent , Papazian Laurent , Guervilly Christophe 
Published: January 2021

BackgroundOesophageal pressure (Poes) is used to approximate pleural pressure (Ppl) and therefore to estimate transpulmonary pressure (PL). We aimed to compare oesophageal and regional pleural pressures and to calculate transpulmonary pressures in a prospective physiological study on lung transplant recipients during their stay in the intensive care unit of a tertiary university hospital.MethodsLung transplant recipients receiving invasive mechanical ventilation and monitored by oesophageal manometry and dependent and nondependent pleural catheters were investigated during the post-operative period. We performed simultaneous short-time measurements and recordings of oesophageal manometry and pleural pressures. Expiratory and inspiratoryPLwere computed by subtracting regionalPplorPoesfrom airway pressure; inspiratoryPLwas also calculated with the elastance ratio method.Results16 patients were included. Among them, 14 were analysed. Oesophageal pressures correlated with dependent and nondependent pleural pressures during expiration (R2=0.71, p=0.005 and R2=0.77, p=0.001, respectively) and during inspiration (R2=0.66 for both, p=0.01 and p=0.014, respectively).PLvalues calculated usingPoeswere close to those obtained from the dependent pleural catheter but higher than those obtained from the nondependent pleural catheter both during expiration and inspiration.ConclusionsIn ventilated lung transplant recipients, oesophageal manometry is well correlated with pleural pressure. The absolute value ofPoesis higher thanPplof nondependent lung regions and could therefore underestimate the highest level of lung stress in those at high risk of overinflation.
Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia
Authors: Moreno Gerard , Rodríguez Alejandro , Sole-Violán Jordi , Martín-Loeches Ignacio , Díaz Emili , Bodí María , Reyes Luis F. , Gómez Josep , Guardiola Juan , Trefler Sandra , Vidaur Loreto , Papiol Elisabet , Socias Lorenzo , García-Vidal Carolina , Correig Eudald , Marín-Corral Judith , Restrepo Marcos I. , Nguyen-Van-Tam Jonathan S. , Torres Antoni 
Published: January 2021

BackgroundThe relationship between early oseltamivir treatment (within 48 h of symptom onset) and mortality in patients admitted to intensive care units (ICUs) with severe influenza is disputed. This study aimed to investigate the association between early oseltamivir treatment and ICU mortality in critically ill patients with influenza pneumonia.MethodsThis was an observational study of patients with influenza pneumonia admitted to 184 ICUs in Spain during 2009–2018. The primary outcome was to evaluate the association between early oseltamivir treatment and ICU mortality compared with later treatment. Secondary outcomes were to compare the duration of mechanical ventilation and ICU length of stay between the early and later oseltamivir treatment groups. To reduce biases related to observational studies, propensity score matching and a competing risk analysis were performed.ResultsDuring the study period, 2124 patients met the inclusion criteria. All patients had influenza pneumonia and received oseltamivir before ICU admission. Of these, 529 (24.9%) received early oseltamivir treatment. In the multivariate analysis, early treatment was associated with reduced ICU mortality (OR 0.69, 95% CI 0.51–0.95). After propensity score matching, early oseltamivir treatment was associated with improved survival rates in the Cox regression (hazard ratio 0.77, 95% CI 0.61–0.99) and competing risk (subdistribution hazard ratio 0.67, 95% CI 0.53–0.85) analyses. The ICU length of stay and duration of mechanical ventilation were shorter in patients receiving early treatment.ConclusionsEarly oseltamivir treatment is associated with improved survival rates in critically ill patients with influenza pneumonia, and may decrease ICU length of stay and mechanical ventilation duration.
A feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE)
Authors: Northgraves Matthew , Cohen Judith , Allgar Victoria , Currow David , Hart Simon , Hird Kelly , Hodge Andrew , Johnson Miriam , Mason Suzanne , Swan Flavia , Hutchinson Ann 
Published: January 2021

Chronic breathlessness, persistent and disabling despite optimal treatment of underlying causes, is a prevalent and frightening symptom and is associated with many emergency presentations and admission to hospital. Breathlessness management techniques used by paramedics may reduce the need for conveyance to hospital. The Breathlessness RElief AT HomE study (BREATHE) aims to explore the feasibility of conducting a definitive cluster randomised controlled trial (cRCT) for people with acute-on-chronic breathlessness who have called an ambulance, to evaluate the effectiveness and cost-effectiveness of a paramedic-administered non-pharmacological breathlessness intervention.The trial is a mixed-methods feasibility cRCT. Eight paramedics will be randomised 1:1 to deliver either the BREATHE intervention in addition to usual care or usual care alone at call-outs for acute-on-chronic breathlessness. Sixty participants will be recruited to provide access to routine data relating to the index call-out with optional follow-up questionnaires at 14 days, 1 month and 6 months. An in-depth interview will be conducted with a subgroup. Feasibility outcomes relating to recruitment, data quality (especially candidate primary outcomes), and intervention acceptability and fidelity will be collected as well as providing data to estimate a sample size for a definitive trial.Yorkshire and The Humber–Sheffield Research Ethics Committee approved the trial protocol (19/YH/0314). The study results will inform progression to, or not, and design of a main trial according to predetermined stop-go criteria. Findings will be disseminated to relevant stakeholders and submitted for publication in a peer-reviewed journal.
Fabrication and Characterization of Black GaAs Nanoarrays via ICP Etching
Authors: Ma Jing , Zhao Yongqiang , Liu Wen , Song Peishuai , Yang Liangliang , Wei Jiangtao , Yang Fuhua , Wang Xiaodong 
Published: January 2021

AbstractGaAs nanostructures have attracted more and more attention due to its excellent properties such as increasing photon absorption. The fabrication process on GaAs substrate was rarely reported, and most of the preparation processes are complex. Here, we report a black GaAs fabrication process using a simple inductively coupled plasma etching process, with no extra lithography process. The fabricated sample has a low reflectance value, close to zero. Besides, the black GaAs also displayed hydrophobic property, with a water contact angle of 125°. This kind of black GaAs etching process could be added to the fabrication workflow of photodetectors and solar cell devices to further improve their characteristics.