bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colocalized, Bidirectional Optogenetic Modulations in Freely Behaving Mice with a Wireless Dual-Color Optoelectronic Probe
Authors: Li Lizhu , Lu Lihui , Ren Yuqi , Tang Guo , Zhao Yu , Cai Xue , Shi Zhao , Ding He , Liu Changbo , Cheng Dali , Xie Yang , Wang Huachun , Fu Xin , Yin Lan , Luo Minmin , Sheng Xing 
Published: June 2021

ABSTRACTThe precise control of neural activities at both cellular and circuit levels reveals significant impacts on the fundamental neuroscience explorations and medical applications. Optogenetic methods provide efficient cell-specific modulations, and the ability of simultaneous neural activation and inhibition in the same brain region of freely moving animals is highly desirable and being actively researched. Here we report bidirectional neuronal activity manipulation accomplished by a wireless, dual-color optogenetic probe in synergy with the co-expression of two spectrally distinct opsins (ChrimsonR and stGtACR2) in a rodent model. Based on vertically assembled, thin-film microscale light-emitting diodes (micro-LEDs) with a lateral dimension of 125 × 180 µm2 on flexible substrates, the dual-color probe shows colocalized red and blue emissions and allows chronic in vivo operations with desirable biocompatibilities. In addition, we discover that neurons co-expressing the two opsins can be deterministically evoked or silenced under red or blue irradiations. Implanted in behaving mice, the wirelessly controlled dual-color probe interferes with dopaminergic neurons in the ventral tegmental area (VTA), increasing or decreasing dopamine levels with colocalized red and blue stimulations. Such bidirectional regulations further generate rewarding and aversive behaviors of freely moving mice in a place preference test and interrogate social interactions among multiple mice. The technologies established here will create numerous opportunities and profound implications for brain research.
Symbiosis increases population size and buffers environmental fluctuations in a physiologically-structured model parameterized for thyasirid bivalves
Authors: Mariño Joany , Dufour Suzanne C. , Hurford Amy 
Published: June 2021

AbstractSymbioses whereby one partner provisions a nutritional resource to the other may alter energy allocation towards reproduction and survival in the recipient partner, potentially impacting population dynamics. Asymbiotic thyasirid bivalves feed predominantly on free-living bacteria, which fluctuate in abundance due to seasonality-driven temperature variations. Symbiotic thyasirids are mixotrophs, gaining nutrients from free-living bacteria and symbiotic bacteria that they host on their enlarged gills. Symbiotic bacteria may function as an additional energy reserve for thyasirids, allowing the hosts to allocate more energy to reproduction. We hypothesize that, for symbiotic thyasirids, the symbionts are a nutritional source that mitigates resource limitation. Using Dynamic Energy Budget theory, we built a physiologically-structured population model assuming equal mortality rates in both species. We find that without seasonal fluctuations, symbiotic thyasirids have higher abundances than asymbiotic thyasirids since the symbionts increase reproduction. Both species have similar population sizes in fluctuating environments, suggesting different adaptations to seasonality: asymbiotic thyasirids have adapted their physiology, while symbiotic thyasirids have adapted through mixotrophy. Our results highlight the significance of linking individual energetics and life-history traits to population dynamics and are the first step to-wards understanding the role of symbioses in population and community dynamics.
Celebrating a decade ofInternational Journal of Lean Six Sigma– a bibliometric analysis to uncover the “as is” and “to be” states
Authors: Puram Praveen , Gurumurthy Anand 
Published: June 2021

PurposeInternational Journal of Lean Six Sigma(IJLSS) has completed a decade. To celebrate the same, this study aims to review the articles published in IJLSS from its inception to the year 2020. The journal’s trends and professional impact over the years are investigated and potential future research directions are proposed.Design/methodology/approachA bibliometric analysis comprising of citation, co-citation and keyword co-occurrence methods is used on all the articles published in IJLSS till the year 2020. Content analysis is further done to analyse the type of research, type of industry studied and the articles’ target audience.FindingsThe journal has improved its reputation, productivity and impact over the years. Currently, studies published in IJLSS have been cited more than 5,000 times, with the most prominent themes being Six Sigma, Lean Six Sigma (LSS) and Lean in manufacturing and services. Researchers from India, the USA and the UK have contributed a significant number of publications. Most of the work published is case-based. There is a need for more empirical or survey-based research having high generalizability. Future studies should also focus on integrating LSS with emerging topics such as sustainability, Industry 4.0 and the like.Research limitations/implicationsThe study provides evidence of the impact of IJLSS and highlights the trend in the domain of LSS. It can be of use for the editorial board members to identify potential areas to focus on in the future. Researchers can use it to further their research by working on the research gaps identified.Originality/valueThis paper is the first to trace the progress of IJLSS from its inception till the year 2020.
Collaborative idea exchange and material tinkering influence families’ creative engineering practices and products during engineering programs in informal learning environments
Authors: Kim Soo Hyeon , Zimmerman Heather Toomey 
Published: June 2021

Purpose
This paper aims to investigate how families’ sociomaterial experiences in engineering programs held in libraries and a museum influence their creative engineering practices and the creativity expressed in their products derived from their inquiry-driven engineering activities.

Design/methodology/approach
This research project takes a naturalistic inquiry using qualitative and quantitative analyses based on video records from activities of 31 parent–child pairs and on creativity assessment of products that used littleBits as prototyping tools.

Findings
Families engaged in two sociomaterial experiences related to engineering – collaborative idea exchange and ongoing generative tinkering with materials – which supported the emergence of novel ideas and feasible solutions during the informal engineering programs. Families in the high novelty score group experienced multiple instances of collaborative idea exchange and ongoing generative tinkering with materials, co-constructed through parent-child collaboration, that were expansive toward further idea and solution generation. Families in the low novelty score group experienced brief collaborative idea exchange and material tinkering with specific idea suggestions and high involvement from the parent. An in-depth case study of one family further illustrated that equal engagement by the parent and child as they tinkered with the technology supported families’ creative engineering practices.

Originality/value
This analysis adds to the information sciences and learning sciences literatures with an account that integrates methodologies from sociocultural and engineering design research to understand the relationship between families’ engagement in creative engineering practices and their products. Implications for practitioners include suggestions for designing spaces to support families’ collaborative idea exchange and ongoing generative tinkering to facilitate the development of creative engineering practices during short-term engineering programs.
Does “CHALTA HAI”culture negatively impacts sustainability of business firms in India? An empirical investigation
Authors: Chatterjee Sheshadri , Chaudhuri Ranjan , Vrontis Demetris , Thrassou Alkis 
Published: June 2021

PurposeChalta hai (it is fine or it is acceptable) is an Indian cultural phenomenon that influences attitude towards work and business and diachronically adversely affects both. The purpose of this study is to explore its impact on the sustainability of business firms operating in India.Design/methodology/approachThe research has firstly undertaken a theoretical study towards the development of appropriate hypotheses and a corresponding conceptual model, with emphasis on the effects of chalta hai culture as a moderator of the predictor-sustainability linkages. The model has been validated statistically through partial least square- structural equation modelling analysis of usable feedbacks from 349 respondents.FindingsThe research has concluded that the cultural notion of chalta hai impacts adversely the sustainability of business firms operating in India, with its effects being dominant.Research limitations/implicationsThe research has scholarly and executive implications, as well as socio-cultural implications. The sample, however, allows for conclusions to be drawn reliably but with limited generalizability. Additionally, only three predictors have been considered, bestowing upon future research the task of building on the present model through additional pertinent predictors and boundary conditions that will enhance its explanative power.Practical implicationsThe research has provided a scientifically developed model that guides Indian firm managers through appropriate steps that dissuade stakeholders from exhibiting the behavioural traits and attitudes of chalta hai culture, highlighting along the way its detrimental effects on Indian business sustainability.Originality/valueThere is little research on the business impacts of chalta hai and regarding the sustainability perspective/focus. In addition, this is in sharp contrast to the spread and impact of the phenomenon. This research and its findings, therefore, are valuable with regard to both their wider context (“chalta hai” business effects) and their specific focus (sustainability).
The legal framework for the Syrian urban reconstruction
Authors: Porras-Gómez Antonio-Martín 
Published: June 2021

Purpose
As the Syrian civil war winds down, the massive reconstruction of the devastated cities has become a recurring subject of political and scientific discussions. A crucial question pervades all these debates: is the current legal framework adequate for confronting the reconstruction challenges in an effective way? With the purpose of understanding and informing the question, this study aims to analyze the most important legal instrument for the Syrian urban reconstruction, Law 10/2018.

Design/methodology/approach
A functional analysis of the legal text and of its effective implementation is provided. Following a doctrinal legal approach, internal inconsistencies are highlighted, as well as possible “legal gaps” that might allow and favor instances of disrespect of the rule of law and regulatory capture.

Findings
The main hypotheses discussed are, first, from a descriptive-analytical perspective, that the neoliberal trend in the Syrian political economy underpins the legal framework for the Syrian reconstruction. Second, from a design perspective, that, while offering a strong mechanism for disciplining the Syrian urban planning, Law 10/2018 does not warrant a scenario of respect of the rule of law and seems too easy prey for regulatory capture.

Originality/value
While the most recent and prominent legal instrument aimed to frame Syrian post-war reconstruction, Law 10/2018, has been subject to multiple policy analyzes and critiques, these have focused almost exclusively on its presumed warchitecture dimension, lacking contextual depth and, most worryingly, ignoring any kind of doctrinal legal analysis. Setting the Law 10/2018 in its legal context is something that has not been done yet, even if, according to their own ontology, legal provisions have to be understood within the context of the legal system they are inserted in. This paper delves into the subject, analyzing the legal text, its juridical context and the way it has been interpreted by the administrative decision-maker while looking at instances where the axiological goals constitutionally proclaimed and legally enshrined might be prevented by the very regulatory configuration.
Clinical features, management, and outcome of hemodialysis patients with SARS‐CoV‐2
Authors: Sahin Burcın , Kose Sennur , Eren Gulhan , Yoruk Gulsen 
Published: June 2021

AbstractThe aim of the study was to evaluate the clinical features of the patients on HD with COVID‐19 and determine the prognostic factors. In this single‐center prospective study, a total of 58 chronic renal failure patients on HD and diagnosed COVID‐19 infection were enrolled in the study. The patients were divided into two groups according to their need for intensive care unit referral. Demographic features of the patients, clinical manifestations, laboratory data, treatments, and clinical outcome were evaluated. The mean age of 58 HD patients was 63.2 ± 13.8 (30–93) years and female–male ratio was 0.34. SARS‐CoV2‐PCR positivity rate was 32.8%. 85.2% of patients (n = 46) had bilateral lesions and 14.8% (n = 8) had unilateral one lesion in chest CT. The most common symptoms were fatigue (in 44 patients, 80%) and dyspnea (in 31 patients, 56.4%). The most common comorbidity was HT (in 37 patients, 67.3%). The patients who need intensive care and died were older (p = 0.015). We observed lower platelet and eosinophil counts, potassium levels, higher AST, troponin and CRP levels in the group of patients who need intensive care and died than the group who survived (p = 0.043, 0.005, 0.033, 0.007, 0.001, <0.001, respectively). 15.5% of the patients (n = 9) were transferred to intensive care unit. Among them, two were discharged with cure and seven patients died. Mortality rate was 12.1%. Older age, lower platelet and eosinophil counts and higher AST, troponin and CRP levels were prognostic risk factors in our HD patients who needed intensive care.
Randomized phase 2 study comparing irinotecan versus amrubicin as maintenance therapy after first‐line induction therapy for extensive disease small cell lung cancer (HOT1401/NJLCG1401)
Authors: Tanaka Hisashi , Hasegawa Yukihiro , Fujita Yuka , Nakamura Atsushi , Kikuchi Eiki , Kawai Yasutaka , Harada Toshiyuki , Watanabe Naomi , Yokouchi Hiroshi , Usui Kazuhiro , Saito Ryota , Watanabe Hiroshi , Masuda Tomomi , Fukuhara Tatsuro , Kudo Keita , Honda Ryoichi , Oizimi Satoshi , Maemondo Makoto , Inoue Akira , Morikawa Naoto 
Published: June 2021

AbstractBackgroundA cisplatin plus irinotecan (CPT‐11) regimen is used for patients with extensive disease small cell lung cancer (ED‐SCLC). Amrubicin (AMR) is primarily used for relapsed SCLC. The HOT1401/NJLCG1401 trial, an open‐label randomized phase II trial, was designed to assess the benefit of maintenance therapy in patients with ED‐SCLC who responded to induction therapy.MethodsPatients with histologically‐ or cytologically‐confirmed ED‐SCLC were included and were treated with an induction therapy of four cycles of cisplatin (60 mg/m2 on day 1) plus CPT‐11 (60 mg/m2 on days 1, 8, and 15) every four weeks. After induction therapy, patients who had nonprogressive disease were randomized to receive either maintenance CPT‐11 (60 mg/m2 on days 1 and 8) every three weeks, or AMR (35 mg/m2 on days 1–3) every three weeks.ResultsA total of 34 patients were enrolled; 20 patients had progressive disease or received incomplete induction chemotherapy. Finally, 14 patients were randomly assigned to receive CPT‐11 (n = 7) or AMR (n = 7). This study was terminated prematurely because of low patient accrual. The overall objective response rate was 73%, the median PFS was 5.7 months (95% confidence interval [CI]: 3.6–11.8), and the median overall survival was 20.1 months (95% CI: 13.7–not reached). No statistically significant difference in progression‐free survival (PFS) were noted between patients treated with CPT‐11 and those treated with AMR. There were no treatment‐related deaths in this study.ConclusionsMaintenance therapy with CPT‐11 or AMR after induction therapy might be effective in some patients.
A seven‐year study of the response of woodland birds to a large‐scale wildfire and the role of proximity to unburnt habitat
Authors: Murphy Michael J. , Jones Hugh A. , Koen Terry 
Published: June 2021

AbstractFire is a major ecological driver in many Australian ecosystems, and large‐scale wildfires can impact on faunal assemblages at a landscape scale. Monitoring the response of the avian community and individual bird species following a 92 039 ha wildfire in the Pilliga Forest, in temperate inland south‐eastern Australia, showed an initial decline in species richness and changes in community composition, followed by gradual recovery. Recovery was not complete by the end of the seven‐year study. Eighteen species (including Speckled Warbler Chthonicola sagittata and Eastern Yellow Robin Eopsaltria australis) were identified as likely to be fire sensitive and nine species (including Australian Magpie Cracticus tibicen and Red‐capped Robin Petroica goodenovii) as likely to respond positively to fire at the time scale of this study. Another 11 species (including Dusky Woodswallow Artamus cyanopterus and Jacky Winter Microeca fascinans) appeared to favour burnt areas close to the fire edge. Guild‐level patterns included an overall negative response to fire by insectivores, granivores/frugivores and declining woodland birds and a positive response by predators. The avian community recovered more quickly at burnt sites close to (within 2 km of) the fire edge compared to more remote sites more than 4 km from unburnt habitat, suggesting that proximity to unburnt areas (and therefore fire extent) is likely to be a key consideration in understanding the post‐fire recovery of birds.
Depression predicts emotion acceptance beliefs in early adolescence: A longitudinal investigation
Authors: Harvey Lauren J. , White Fiona A. , McAulay Claire E. 
Published: June 2021

ObjectivesAdolescence is a time period which confers significant risk for the development of psychopathology. There is increasing consensus within the literature that beliefs about one’s emotional experience are important and may present a unique risk factor during this time period. However, to date, there has been no longitudinal examination of the relationship between depression and specific beliefs regarding the acceptability of experiencing and expressing emotion in young people.DesignThe present study used a cross‐lagged longitudinal design with questionnaires completed at two waves spaced 8 months apart.Methods506 participants (50.60% female) aged 12–15 years completed the Beliefs about Emotion questionnaire to assess for beliefs regarding the acceptability of experiencing and expressing emotions, and the depression subscale of the DASS‐21 to measure depressive symptoms.ResultsGreater depressive symptoms were associated with more negative beliefs about emotion at both time points. More negative beliefs about emotion at T1 did not significantly predict greater depressive symptoms at T2. However, greater depressive symptoms at T1 predicted significantly more negative beliefs about emotions at T2.ConclusionsGreater beliefs about the unacceptability of experiencing or expressing emotions do not appear to predispose young people to depression. Rather, these beliefs appear to emerge following earlier experiences of depressive symptoms. Further research is needed over multiple measurement waves to further elucidate the relationship between emotion acceptance beliefs and depressive symptoms across adolescence into adulthood and whether such beliefs may predict future depressive episodes indirectly via difficulties in emotion regulation.Practitioner points

Current findings suggest that more negative beliefs about emotion, specifically, beliefs about the unacceptability of experiencing or expressing emotions do not represent a key risk factor for the onset of depressive symptoms in early adolescence. Rather, current evidence suggests these beliefs emerge following depressive symptoms.

Given these findings, universal prevention programmes targeting valuation beliefs regarding emotion acceptability are less likely to be effective for this developmental age group.

It is important to assess for beliefs that an individual may hold regarding their emotional states alongside symptoms, as these beliefs are associated with greater clinical severity of depressive symptoms.

Further research, over multiple measurement waves, is needed to clarify whether emotion acceptability beliefs may predict future depressive episodes indirectly via difficulties in emotion regulation.
‘Wishes and feelings’: Misunderstandings and missed opportunities for participation in child protection proceedings
Authors: Dillon Jo 
Published: June 2021

AbstractThe gathering of ‘wishes and feelings’ in UK child protection proceedings (s.53 Children Act 2004) should highlight the child's opinion of social work intervention and services provided. However, with no statutory social work guidance on participation currently in place, children frequently miss opportunities to be involved in their own child protection planning. This paper is drawn from a 3‐year study into participation in child protection social work. It includes findings from qualitative interviews, and one focus group, with social workers, parents, children and participation workers, from three local authorities in the United Kingdom. The findings revealed some examples of significant gaps in service provision, particularly from the perspective and understanding of the child. The skewed translation of wishes and feelings legislation, along with its subsequent (and often inadequate) application to practice, prevents children from understanding and responding to social work intervention and can lead to idiosyncratic practice. This paper provides recommendations for a practical response to practitioner dilemmas regarding wishes and feelings and bridges the gap between research and practice.
Quality changes of clinical practice guidelines for respiratory diseases in China: A systematic review
Authors: Wan Kai‐rui , Zeng Guang‐qiao , Li Yao , Wu Jun‐wan , Zou Bang‐yu , Liang Heng‐rui , Jiang Mei 
Published: June 2021

AbstractBackgroundAfter the low quality of Chinese clinical practice guidelines (CPGs) for respiratory diseases published from 1979 to 2013 was reported, some handbooks were published to standardize guidelines’ development recently. There was a great increase in the production and dissemination of CPGs annually in China, whose quality and potential impact were unknown.MethodsA systematic search of four literature databases was performed for the period January 2013 to December 2018 to identify Chinese CPGs for respiratory diseases. Eligible CPGs were evaluated using the appraisal of guidelines for research and evaluation II (AGREE II) instrument.ResultsA total of 197 CPGs were identified for review. Compared with the result of previous study, the increased scores of the six AGREE II domains were screened: Scope and purpose (57.3% vs. 57.8%), Stakeholder involvement (17.6% vs. 25.0%), Rigor of development (10.2% vs. 13.2%), Clarity and presentation (55.2% vs. 58.4%), Applicability (9.3% vs. 25.9%), and Editorial independence (1.1% vs. 6.3%). The improved overall assessment for included CPGs were: Recommended (4, 2.0% vs. 0, 0%) and Recommended with modifications (26, 13.2% vs. 3, 2.8%). The improved level of evidence used to make recommendations were 59, 11.9% versus 168, 22.4% and 88, 17.7% versus 195, 26.0%, A and B, respectively.ConclusionsThe overall quality of CPGs for respiratory diseases published from 2013 to 2018 in China was slightly improved, but had a big gap with the optimum level, especially in Rigor of development and Editorial independence. Increased efforts are required to enable the development of high‐quality evidence‐based CPGs for respiratory diseases.