bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelatihan Pemanduan Bakat dan Minat Olahraga Berbasis Teknologi Sport Search Pada Guru Penjas di Daerah Penajam Paser Utara
Authors: Cahyono Didik , Ramli Buhari Muhammad , Jupri Jupri 
Published: August 2021

Menemukan bakat seseorang merupakan sesuatu yang unik dan memerlukan caranya masing-masing. Susunan/struktur bakat adalah sangat komplek. Bakat adalah suatu potensi yang ditentukan secara genetis/keturunan, tidak stabil serta banyak dipengaruhi oleh keadaan lingkungan sekitar. Alat penemuan bakat diantaranya adalah untuk olahraga umum dengan sport search yang dikembangkan di Australia. Kemampuan mengoperasikan sport search sangat diperlukan bagi guru Penjas dalam penelusuran bakat dan minat anak didiknya. Kemampuan ini sangat diperlukan dalam usaha mencari bibit-bibit potensial olahraga yang ada di daerah.untuk menyelesaikan permasalahan yang dihadapi mitra, solusi yang ditawarkan adalah melakukan pelatihan kemampuan guru dalam mengoperasikan sport search. Desain materi pelatihan diharapkan dapat meningkatkan beberapa kemampuan guru, diantaranya adalah mampu menemukan bakat “terpendam” seorang anak di daerah Penajam Paser Utara. Peserta dalam pelatihan ini sebanyak 30 orang guru Pendidikan Jasmani Sekolah Dasar dan Sekolah Menengah Pertama. Pelatihan pemanduan bakat olahraga melalui aplikasi sport search ini sangat membantu guru PJOK dalam melakukan pemanduan bakat yang di miliki siswa khusunya dalam cabang olahraga. pengabdian pada masyarakat sebenarnya sangat diperlukan oleh para guru, terutama adanya pendampingan pasca kegiatan sehingga ada kesempatan bagi para guru untuk menerima umpan balik dari kegiatan aplikasi pengetahuan dan ketrampilan yang disampaikan.
Pelatihan TOEFL Dengan Metode Cooperative Integrated Reading And Composition Untuk Mencapai Nilai Ideal di Masa Pandemi
Authors: Syamsurrijal Syamsurrijal , Ceriyani Miswaty Titik , Pahrul Hadi Muhammad Zaki 
Published: August 2021

Pelatihan TOEFL dengan metode Cooperative Integrated Reading And Composition bertujuan untuk membantu para dosen dan mahasiswa di beberapa perguruan tinggi di Nusa Tenggara Barat dalam upaya untuk meningkatkan nilai TOEFL (Test of English as foreign language) dimasa pandemi. Sulitnya menentukan metode dan media yang tepat dimasa pandemi bagi mahasiswa dan dosen untuk untuk mencapai TOEFL ideal menjadi alasan utama dilaksanakannya Pengabdian keada masyarakat ini Pengabdian kepada masyarakat ini bertujuan untuk memberikan tidak hanya pengetahuan tetapi juga kesiapan untuk menghadapi ujian TOEFL (Test of English as Foreign Language) bagi mahasiswa dan dosen di Nusa Tenggara Barat. Pengabdian kepada masyarakat ini dilaksanakan secara online dengan meggunakan teknologi zoom sebagi media pembelajaran selama satu bulan.Masyarakat sasaran adalah masyarakat kampus yaitu mahasiswa dan dosen dari berbagai perguruan tinggi Nusa Tenggara Barat. Metode yang digunakan dalam pengabdian kepada masyarakat ini adalah dengan metode Cooperative Integrated Reading and Composition (CIRC) yaitu peserta dibagi menjadi beberapa kelompok, kemudian diberikan tips dan strategi dalam menjawab tes TOEFL. Masing-masing kelompok berdiskusi dan bertukar pikiran dalam menjawab semua soal-soal dalam TOEFL. Biaya kegiatan pengabdian kepada masyarakat ini sepenuhnya bersumber dari tim pelaksana pengabdian. Setelah pelaksanaan kegiatan pengabdian kepada masyarakat ini, peserta memiliki kemampuan dan kesiapan serta nilai yang cukup significant dari sebelumnya. Hal ini dapat dibuktikan dengan hasil Post Test Peserta setelah mengikuti pelatihan menunjukkan perubahan yang sangat positif
Pelatihan Desain 3D Menggunakan Sketch Up Guna Mendukung Kinerja Bidang Kewilayahan Pemerintahan Desa Karangturi Banyumas
Authors: Indartono Kuat , Adhi Kusuma Bagus , Hermawan Hellik , Adhy Yusuf Kurniawan Nur 
Published: August 2021

Desa Karangturi merupakan salah satu dari 19 desa yang ada di Kecamatan Sumbang. Perkembangan dan kemandirian suatu desa tergantung dari produktivitas individu dan organisasi Pemerintahan Desa. Berdasarkan hasil wawancara dengan salah satu perangkat desa Bapak Nasrul menyampaikan beberapa permasalahan, salah satunya adalah sekitar 50% dari penduduk desa pada usia produktif belum memiliki soft skill yang memadai. Permasalahan lainnya adalah bahwa dari pekerjaan aparatur desa dibutuhkan soft skill yang dapat meringankan pekerjaan tersebut yaitu berupa perencanaan dan desain tata ruang desa serta peta sosial desa. Solusi yang ditawarkan untuk mengatasi masalah mitra yaitu, memberikan pelatihan desain 3D menggunakan Sketch Up guna mendukung kinerja Bidang Kewilayahan Pemerintahan Desa Karangturi, Kabupaten Banyumas. Metode yang digunakan yaitu dengan memberikan pelatihan 3D menggunakan Sketch Up dan dievaluasi dengan menggunakan kuesioner untuk mengetahui tingkat pemahaman peserta. Kegiatan ini berlangsung selama dua hari dengan memberikan materi dasar menggambar di hari pertama dan membuat desain 3D di hari kedua dengan menggunakan software Sketch Up. Hasil dari pelatihan ini berupa desain 3D rumah sederhana yang dibuat oleh peserta. Tingkat pemahaman peserta pelatihan tercapai 70% pada level paham, 20% pada level sangat paham dan 10% netral. Peserta yang sudah mendapatkan modal berupa pelatihan desain 3D menggunakan Sketch Up diharapkan mampu mengembangkan skill yang dimiliki untuk mendesain infrastruktur fisik desa.
Religious Racism in Brazil: Introduction
Authors: Cerqueira Gustavo Melo , Boaz Danielle N. 
Published: August 2021

ABSTRACT
The six essays in this roundtable provide firsthand accounts by devotees and activists in Brazil who experienced incidents of religious racism or sought to bring the assailants to justice. Many such incidents, which include harassment, physical violence, and destruction of property, among other things, are perpetrated by members of evangelical Christian churches.
A Sustained Presence: Synagogue Buildings in Galilee during the Early Islamic Period and Later
Authors: Bonnie Rick 
Published: August 2021

ABSTRACTThe majority of archaeological studies on late antique monumental synagogues focus their discussion on the origin and production of these buildings, their decoration, and their use. How these buildings were used, experienced, and remembered in subsequent periods remains little explored. Following a building-biography approach, this article aims to explore how the building remains of synagogues in Galilee persisted into the early Islamic period and beyond, and what the physical state of these monuments and the small finds found within them tell us about how later communities used, viewed, and remembered these spaces. The article explores the remains of several synagogue sites in eastern Galilee using archaeological data, medieval Muslim and Jewish traveler accounts, and early modern depictions of ruins.
ANALITYCAL SOLUTION OF THE ONE DIMENSIONAL NONLINEAR TRANSIENT HEAT CONDUCTION PROBLEM USING GREEN’S FUNCTIONS
Authors: Ribeiro S. S. , Oliveira G. C. , Oliveira J. R. F. , Guimarães G. 
Published: August 2021

Analytical solutions showed to be an important and strong tool for understand thermal problems using mathematic tools. In this work we propose an approach about one dimensional analytical solution for a nonlinear transient heat conduction problem, were used mathematical elements such as Kirchhoff transformation, Green’s functions and the combination of them. The combination of this two methods showed that was possible to determinate an analytical solution for the nonlinear thermal problem, and showed a good approximation when compared with results from numerical methods.
EFEKTIVITAS LEARNING MANAGEMENT PADA DIKLAT TEKNIS SUBSTANTIF PKG DAN PKB BAGI GURU MADRASAH DILINGKUNGAN BALAI DIKLAT KEAGAMAAN BANDUNG TAHUN 2018
Authors: Fauzan Mohamad 
Published: August 2021

Abstrak
Penelitian ini dilakukan dengan tujuan untuk mengetahui efektivitas pengelolaan pembelajaran pada diklat PKG dan PKB bagi guru Madrasah ‘Aliyah di Balai Diklat Keagamaan Bandung pada Tahun 2018 dan untuk mengetahui kendala serta hambatan yang ditemui selama dilaksanakan proses kediklatan. Jenis penelitian deskriptif dengan pendekatan kualitatif pada penelitian ini untuk mengungkap fakta dan fenomena dilapangan apa adanya. Teknik pengumpulan data pada penelitian ini adalah menggunakan lembar observasi dan wawancara tidak terstruktur. Peneliti menggunakan teknik analisis data kualitatif melalui tiga tahapan analisis, yaitu reduksi data, display, dan verifikasi. Hasil penelitian ini terungkap bahwa proses pembelajaran diklat telah berjalan efektif dengan skor akhir rerata dari semua indikator sebesar 88,53 dengan predikat sangat baik atau terpenuhi dengan sangat baik. Hambatan-hambatan yang ditemukan selama proses pengelolaan diklat terletak pada pengelolaan materi diklat dan pengelolaan organisasi pembelajaran. Solusi nya adalah dengan menggunakan metode pembelajaran yang bervariasi melalui pengelompokkan peserta diklat dan kolaborasi dalam mengerjakan lembar kerja yang telah disediakan widyaiswara.
Японы жижиг дунд үйлдвэрийн хөгжил, цаашдын хандлага
Authors: Б Сэржав 
Published: August 2021

Япон улсад дайны дараах эдийн засгийн сэргэлт, 60-70-аад оны жигд өндөр хөгжил болон түүнээс хойших эдийн засгийн удаан хугацааны тогтвортой өсөлтийн явцад жижиг дунд үйлдвэр улс орны эдийн засгийн бүхий л салбарт ихээхэн чухал үүрэг гүйцэтгэх болжээ. Өнгөрсөн зууны 80-аад он гэхэд жижиг дунд үйлдвэр нь том үйлдвэрүүдтэй бие биеэ нөхөн орших хэмжээнд хүрч, хөдөлмөрийн хуваарийн энэ тогтолцоо нь Японы шитаүкэ систем хэмээн олон улсын хэмжээнд анхаарал татаж, улс орны эдийн засгийн өрсөлдөх чадварыг өсгөсөн гол хүчин зүйл гэгдэж байв. Жижиг дунд үйлдвэрийг хамарсан шитаүкэ тогтолцооны хөгжлийн үр дүнд Японд түүхий эд материал боловсруулахаас эхлээд тоног төхөөрөмж, эд анги, бүтээгдэхүүн үйлдвэрлэх, угсрах бүх процесс, өөрөөр хэлбэл дотооддоо бэлэн бүтээгдэхүүн хийх үйлдвэрлэлийн стил бий болсон юм.
2010 оны байдлаар Японд нийт үйлдвэрийн газрын 99%-ийг жижиг дунд үйлдвэр эзэлж, нийт ажиллагсдын 78% нь тэнд ажиллаж, аж үйлдвэрийн салбарт гэхэд л нэмүү өртөг шингэсэн бүтээгдэхүүний талаас илүү хувийг жижиг дунд үйлдвэрт үйлдвэрлэж байна. Японы эдийн засагт сүүлийн үед бүтцийн өөрчлөлт явагдаж, үйлдвэрүүд нь далайн чанадад олноор гарах үйл явц үргэлжлэн, аж үйлдвэрийн өмнөх стил өөрчлөгдөж байгаа хэдий ч эдийн засаг, нийгмийн ирээдүйн хөгжилд жижиг дунд үйлдвэрийн гүйцэтгэх үүргийг улам бүр чухалчлан үзэх болж буй талаар тус өгүүлэлд авч үзлээ.

English title: Farther Trends and Development of Small and Medium-sized Enterprises in Japan
ОХУ: Хүний хөгжлийн бодлого ба соёлын хөгжлийн хүчин зүйл
Authors: Х Мандухай 
Published: August 2021

Алив соёлын хөгжлийн үйл явц нь тухайн төр улсын бүтцийн задрал болон улс төрийн дэглэмийн уналт буюу өөрчлөлтөөр тасран саатдаггүй. Тэр л жам ёсоор Орос орны соёлын хөгжил явагдаж байгаа онцлогтой. Нөгөөтэйгүүр өнөөгийн Орос орон маш олон үндэстэн ястнаас бүрэлддэг тул тухайн үндэстний өвөрмөц соёл үйлчилж хөгжиж байгаа учир нэгдмэл нэг соёлын тухай яриа байх ёсгүй. Үүгээрээ Орос орны соёлын хөгжлийн онцлог байгаа юм. Орос орны соёл сүүлийн арав гаруй жилийн турш тус улсын өнгөрсөн үеийн түүхтэй салшгүй холбоотой явж ирэв. Гэхдээ улс төр, эдийн засаг, нийгмийн өнөөгийн байдал төрх, нөхцөл боломж иргэдийн үзэл санаа, оюун сэтгэлгээнд мэдэгдэхүйц нөлөө үзүүлсэн учраас соёлын болон хүний хөгжлийн хүрээнд ч үлэмж нөлөөлсөн нь мэдээж юм. Хамгийн гол нь соёл урлагийн эрх чөлөө олж авсан явдал юм. Өөрөөр хэлбэл коммунист үзэл суртал, улс төрийн намын дарамт “боолчлолоос” чөлөөлөгдсөн явдал. Үүгээр Орос орны соёлын хөгжлийн өргөн дардан зам нээгдсэн бөгөөд түүний хөгжлийн хүчин зүйл нь хүний сайн сайхны үйл хэрэгт бодитой тус нэмэр болж байна.

Russia: Human Development Policy and Cultural Development Factors
The major wealth of any nation is its people. So the man must be in center of all development. For decades, the human development has focused on the economic growth. However, there is a high economic growth, and industrialized in any nation, eventually, the development experience of many countries indicates that there are still poverty and inequality. Therefore, the human development is not only the economic state but it is better to define that this is a complex policy of social system, individual’s living capacity and life ability as well. Hereinafter, I tried to write in this article how the cultural development will impact on the human development.
Хятадын эрчим хүчний аюулгүй байдал ба импортын хамаарал
Authors: Б Отгонбаатар 
Published: August 2021

Энэхүү өгүүлэл нь Хятадын эрчим хүчний аюулгүй байдлын судалгааны голлох арга зүй, онолын суурь маргаан, судлаачдын байр суурийг харьцуулан авч үзэж, Хятадын эрчим хүчний салбарын дотоод нөхцөл байдал болон гадаад бодлогын нарийн төвөгтэй хамаарлыг тайлбарлах багахан оролдлого юм. Энэ хүрээнд БНХАУ-ын импортын хамаарлаа багасгах, эрчим хүчний аюулгүй байдлын орчноо сайжруулахаар зорьж буй бодлого, стратегийг аль нэг онолын тайлбарт шууд автахгүйгээр, тэнцвэртэй, цогцоор нь судлан ойлгоход тустай 4 гол үйл ажиллагааны чиглэлийг мөн онцлон нэрлэж байгаа юм.

China’s Energy- Security and Import Dependency
The paper is attempted to analyze and to compare the mainstream approaches, relevant theoretical debates, prominent scholar's positions on Chinese energy security discussions. By offering 4 special areas of focus, the paper also seeks to provide insights for researchers in order to understand a nexus between domestic factors and China’s foreign policies in energy field with sound and balanced approach.
ХКН-ын XVIII их хурал болон Хятадын нийгэм-эдийн засгийн хөгжлийн талаарх Оросын эрдэмтэн, судлаачдын байр суурь
Authors: Ч Батцэцэг 
Published: August 2021

ХКН-ын XVIII их хурлын үйл явц, онцлог, ач холбогдол, “тав дахь үеийн” шинэ удирдлага, Хятадын нийгэм-эдийн засгийн хөгжлийн асуудлаар гадаадын хэвлэл, мэдээллийн хэрэгслэлээр нийтлэгдсэн материал, Оросын эрдэмтэн, судлаачдын байр суурь, үзэл бодлыг авч үзлээ.

The 18th National Congress of the Communist Party of China and Russian Scholars’ view on Socio-Economic Development of China
The paper aims to examine the proceedings, significance, and specialty of the 18th National Congress of the Communist Party of China and the new rulership of “the fifth generation” and the state of socio-economic development of China in the opinion of international, in particular Russian researchers.
Юань улсын үеийн өртөө
Authors: Т Эрдэнэхишиг 
Published: August 2021

Хүннү нар эдүгээгээс 2000 гаруй жилийн тэртээ Ази, Европыг холбосон хүчирхэг гүрэн байгуулахад элч, улаачийн гүйцэтгэсэн үүрэг асар их байсан нь ойлгомжтой.
Хожмын нүүдэлчдийн төр, улсууд зам харилцааны энэ уламжлалыг залган хөгжүүлснээр Их Монгол улсын үе хүрч XIII зууны үеийн монголчууд дэлхийд анх удаа өртөөг зам тээвэр, харилцаа холбооны цогц сүлжээ болгон зохион байгуулж дэлхийн талыг эзэгнэсэн их гүрний хэмжээнд хэрэглэсэн ажээ.
Монгол улсын үед байгуулагдсан өртөөний тогтолцоо нь Юань улсын үед илүү сайжран хөгжсөн бөгөөд нийт улс даяар 1500 гаруй өртөө (тухайн үед улаачийн газар хэмээн нэрлэгдэж байсан) байгуулсан байна.
Ийнхүү Юань улсын Хубилай хаан дөрвөн зүг, найман зовхисыг холбосон, хааны зарлигыг уламжилж буй элч, алба татвар хураагч, худалдаачин, цэргийнхэн, шашны лам хувраг нарын аюулгүй-байдлыг дээд зэргээр хангасан, өндөр зохион байгуулалттай өртөөний тогтолцоог бий болгож чадсанаараа Монгол, Хятадын төдийгүй дэлхийн зам харилцааны хөгжилд асар их хувь нэмэр оруулсан юм.

Yuan Dynasty Postal System
It is clear that envoys played crucial role in building Hunnu empire which connected Asia, and Europe.
Since then nomads developed this system further, and 13th century Mongolians started using Urtuu (relay posts) as perfect postal, transportation, communication system throughout its vast empire.
Relay posts established during Mongolian empire has been developed even further during Yuan Dynasty, and there were 1500 postal relay stations established.
Kublai Khan, founder of the Yuan Dynasty, could establish perfect postal relay system throughout his empire which safeguarded envoy’s, taxmen’s, traders, military men’s, and religious monk’s safety. This postal relay system establishment not only contributed Mongolian, Chinese postal, transportation, communication system, but also world’s.
A 5 V to 180 V Charge Pump for Capacitive Loads in a 180 nm SOI Process
Authors: Toft Jakob K. , Jorgensen Ivan H. H. 
Published: August 2021

This paper presents two variants of a high step-up ratio charge pump for high voltage micro electro-mechanical system and condenser microphones. The implementations are based on an additive charge pump topology where respectively 46 and 57 cascaded stages are used to generate an output voltage of 182 V from a supply voltage of 5 V. The two charge pumps have been fabricated in a 180 nm SOI process with a breakdown voltage of more than 200 V and respectively occupy an area of 0.52 mm2 and 0.39 mm2. The charge pumps can output up to 182.5 V and 181.7 V and are designed to drive a capacitive load with a leakage of 2 nA. When driven with a 100 kHz clock, their power consumption is respectively 40 µW and 20 µW. The rise time of the charge pumps output from 0 V to 182 V is less than 5 ms. The implemented charge pumps exhibit state-of-the-art performance for very high voltage dc-dc capacitive drive applications.
Cancer occurrence in patients with inflammatory bowel disease in treatment with anti-TNF: report of three cases and literature review
Authors: Amaral Lucas Camargo Gamba Martins do , Correa Luiz Henrique Locks , Accord Cassiano Coral , Santos Thamy dos , Kock Beatriz de Oliveira , Kock Kaiser de Souza 
Published: August 2021

ABSTRACTCase report of three patients with inflammatory bowel disease who underwent treatment with biology therapy and developed respectively: non-Hodgkins lymphoma, colorectal adenocarcinoma, and cholangiocarcinoma after long-term follow-up. They demonstrated that data are currently inconclusive about the development of long-term anti-TNF neoplasias.
Invasive lobular breast carcinoma metastatic to the colon: a case report of a rare condition and its challenges
Authors: Rodrigues Carlos Eduardo , Sermoud Letícia Morais , Gaui Maria Fátima , Souza José Ricardo 
Published: August 2021

ABSTRACTThe most common sites for metastatic breast neoplasm are the bones, lungs, liver, and central nervous system. Metastases to the gastrointestinal tract are rare and especially involve the stomach, more than to the colon. The clinical and radiological presentation of the metastatic disease usually does not aid in making the differential diagnosis between primary neoplastic lesions of the colon or rectum and metastases from breast cancer. This often results in inadequate initial treatment. The clinical, radiological and histopathological diagnoses are challenging, and immunohistochemical analyses become necessary in most cases. Therefore, publication in the medical literature of more cases like this one should be stimulated, with the aim of gaining more data on treatments that are used and hence to clarify what the best approach is, focusing especially on better quality of life and survival for these patients.
Accuracy of ultrasound-guided fine needle aspiration cytology (US-FNAC) to detect axillary involvement in breast cancer
Authors: Gouveia Maria Carolina , Santos Candice Lima , Pereira Isabel Cristina , Souza Ariani Impieri 
Published: August 2021

ABSTRACT
Introduction: Axillary involvement is one of the main prognostic factors in breast cancer. This study aimed to assess the accuracy of ultrasound-guided fine needle aspiration cytology (US-FNAC) to detect axillary involvement in breast cancer and to compare with other methods of axilla assessment: axillary palpation (AP) and isolated axillary ultrasound (A-US). Methods: A retrospective accuracy study was performed using data from medical records of patients assisted at a breast cancer service in Recife, Brazil, between 2013 and 2017. A histopathological result (sentinel lymph node and/or axillary dissection) was adopted as a gold standard. Sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of the AP, the A-US and US-FNAC were calculated. Results: 206 tumors were analyzed. The AP was truly positive in 34.0% of the results similar values were obtained for A-US (36.4%). The lowest incidence of false negative was in the US-FNAC (16.5%). Axillary involvement was identified in 82 (39.8%) cases. The US-FNAC was performed in 79 cases, 51 (64.5%) were identified as true positive and 13 (16.5%) were false negative. When analyzing the comparative results of AP, A-US and the US-FNAC of the axilla with histopathology, it was observed that AP presented an accuracy of 69.9% (95%CI=63.1-76.1), better than the A-US, which its accuracy was 68% (95%CI=61.1-74.3). The US-FNAC showed high specificity (100%, 95%CI=81.9-100%), of PPV at 100% (95%CI=94.3-100%), but with a low NPV (53.6%, 95%CI=33.9-72.5). The best NPV was the AP (59.7%, 95%CI=50.5-68.4). The US-FNAC accuracy was 83.5% (95%CI=73.591.0). Conclusion: The good accuracy associated to the high specificity and the PPV of the US-FNAC suggests it to be a promising examination in the diagnosis of axillary involvement in breast cancer and an ally to better define therapeutic conducts.
Primary breast parenchyma melanoma: case report
Authors: Doria Eduardo , Brunn Gion Aléssio Rocha , Brandão Diego Noya , Ribeiro Rafael Silva , Carvalho Adriano Mata Pires Freire , Brandrão Miguel Ângelo 
Published: August 2021

ABSTRACT
Introduction: Primary breast melanoma is a rare condition and most of cases are associated with melanoma overlying the skin of the breast or metastatic disease site. Primary breast parenchyma melanoma (PBPM) is extremely uncommon with only seven cases reported in the last four decades. Case report: A 44-year-old woman presented with a progressive growth lesion on the right breast in the last 6 months. Initial core biopsy suggested poor differentiated malignant round cells tumor with immunohistochemical confirming melanoma diagnosis. Patient underwent radical modified right mastectomy with final pathological report revealing the diagnosis of PBPM, 10cm x 9cm x 7cm in size. Discussion: After active search on PubMed/MEDLINE database, few case reports were found about PBPM. Radical mastectomy with axillar complete node dissection was the most common initially management. Prognostic was poor in general and only one case presented with no evidence of disease after 1-year follow-up.
Polymorphisms in biotransformation and DNA repair genes, and survival on head and neck squamous cell carcinoma
Authors: Novais Osmar Amorim , Bezerra Débora Diniz , Barbosa Ana Angélica Leal , Marques Cintia Rodrigues , Ferreira Marcílio , Rios-Santos Fabrício , Magalhães da-Silva Thiago 
Published: August 2021

ABSTRACT
Objective:This study analyzed the association between xenobiotic metabolism and DNA repair gene polymorphisms and overall survival (OS) and disease-free survival (DFS) in patients diagnosed with HNSCC in a Brazilian population. Methods: Retrospective study included 91 patients with a confirmed diagnosis of HNSCC. A total of 7 genes were analyzed: XRCC1, HOGG1, CYP1A1, GSTM1, GSTT1, GSTP1 and NAT2. Results: Regarding OS, the largest mean differences were observed comparing GSTT1 rs71748309 null and GSTT1 rs71748309 non-null genotypes (p=0.050). In the gene-gene interaction analysis, the higher difference to OS was observed to the combined genotypes of the GSTM1 rs4025935 and GSTT1 rs71748309 (p=0.286). Regarding DFS, the largest mean differences were observed comparing GSTT1 rs71748309 null and GSTT1 rs71748309 non-null genotypes (p=0.060) and to the combined genotypes of the GSTM1 rs4025935 and GSTT1 rs71748309 (p=0.313). Conclusion: None of the polymorphisms evaluated in xenobiotic metabolism or DNA repair genes were significantly associated with HNSCC survival in our population. Confirmation of these results in larger studies is required.