bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelled marine migrations of Atlantic salmon post-smolts from Irish and Scottish rivers vary interannually with local currents and salinity
Authors: Borland Aislinn , Banas Neil , Gallego Alejandro , Speirs Douglas , Tyldesley Emma , Bull Colin 
Published: December 2024

Abstract
Atlantic salmon (Salmo salar) populations have suffered declines across their range in recent decades, largely attributed to decreasing marine survival rates. The first few months at sea are thought to be a time of particular vulnerability, but investigation into drivers of survival is limited by a lack of knowledge of migratory paths. Here, we model the early marine migration of Atlantic salmon from Scottish and Irish rivers over 27 years. Movement is simulated over the first 3 months at sea using a Lagrangian particle tracking model (FVCOM i-state configuration model) coupled with an active swimming model that is dependent on ocean currents, salinity, and compass direction. Our model is driven by the reanalysis of a high-resolution ocean model (Scottish Shelf Waters Reanalysis Service). Differences in the speed of migrations, the proportion of time spent in different oceanographic regions, and the proportion of migrations reaching the Norwegian Sea are seen between years. These differences are related to changes in local ocean conditions: years with lower on-shelf salinity, stronger on-shelf northwest currents, and stronger shelf-edge currents were associated with greater migration success. Within years, differences in modelled migrations between rivers were best explained by their minimum distance from the continental shelf edge.
Impact of neoadjuvant therapy on angioplastic lobectomy: a retrospective study
Authors: Benkiran Tayeb , Hireche Kheira , Frey Sebastien , Morisot Adeline , Nguyen Aude , Rudondy Quentin , Alcaraz Florent , Guarino Mauro , Cohen Charlotte , Gomez-Caro Abel , Berthet Jean-Phillippe 
Published: December 2024

Abstract

OBJECTIVES
The efficacy of neoadjuvant therapy (NT) prior to angioplastic lobectomy (AL) in non-small cell lung cancer is unclear. This study assessed its impact on morbidity, mortality and 5-year survival.

METHODS
We retrospectively analysed 114 patients who underwent AL at 2 tertiary centres from January 2000 to December 2020. Comparisons were made between patients who received NT and those who did not.

RESULTS
Among the patients, 78 (68.4%) underwent upfront surgery, and 36 (31.6%) received NT. There were no significant differences in postoperative complications (46.2% vs 31.6%, P = 0.42) or mortality rates (0% vs 3.8%, P = 0.55). Pathological upstaging differed significantly (37.2% vs 5.6%, P = 0.0008). Five-year survival rates were comparable (54% vs 38%, P = 0.3).

CONCLUSIONS
Neoadjuvant therapy does not adversely affect morbidity, arterial repair complications or mortality in AL. There are no survival differences at 5 years. AL remains a safe option following NT.
A mediastinal angiomatoid fibrous histiocytoma radically resected with the use of cardiopulmonary bypass and transection of the ascending aorta
Authors: Rabelo Luis Gisli , Tolman Christine , Jonsdottir Brynja , Gudbjartsson Tomas 
Published: December 2024

Abstract
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumour that rarely behaves malignant. We report a radical resection of a mediastinal angiomatoid fibrous histiocytoma, which grew invasively into the pulmonary artery wall, was adherent to the posterior aorta and close to the main stem of the left coronary artery. A transection of the aorta was performed using cardiopulmonary bypass and cardioplegic arrest for a safe and radical removal that resulted in symptom relief.
Understanding Government Public Opinion: How Conspiracy Mentality and Policy Issue Concerns Shape Government Performance Evaluations
Authors: Zhang Bingbing , Mateos Araceli , Gil de Zúñiga Homero 
Published: December 2024

Abstract
Citizens’ assessments of government performance are rooted in their judgement on how public policy responds to their concerns, a key element for a sustainable democracy. However, conspiracy mentality, where individuals believe in larger plans orchestrated by powerful entities or the government, may impact such judgement. To examine the antecedents to people’s assessment about how well the government responds to salient issues in society, this study examines the connection between citizens’ policy concerns, conspiracy mentality, and their assessment of government performance. Analyzing data from an original two-wave panel survey conducted in the United States using cross-sectional, lagged, and autoregressive causal ordinary least squares (OLS) regression models, the study shows that conspiracy mentality is positively related to policy issue concerns, while policy issue concerns are negatively associated with the perception of government performance. Importantly, policy issues concerns significantly mediated this relationship. Individuals with higher levels of conspiracy mentality are more likely to have issue concerns that ultimately shape their negative views on how well the government addresses important problems in society.
Phyletic patterns of bacterial growth temperature in Pseudomonas and Paenibacillus reveal gradual and sporadic evolution towards cold adaptation
Authors: Lee Kihyun , Kim Seong-Hyeon , Moon Seongjoon , Kim Sangha , Lee Changhan 
Published: December 2024

Abstract
Bacterial species adapt to cold environments with diverse molecular mechanisms enabling their growth under low ambient temperature. The emergence of cold-adapted species at macro-evolutionary scale, however, has not been systematically explored. In this study, we performed phylogenetic analysis on the growth temperature traits in the genera that occupy broad environmental and host niches and contain known cold-adapted species. Our results demonstrate that in the genus Pseudomonas, cold-adapted species formed a distinct and conserved clade, whereas in Paenibacillus, cold-adapted species were sporadically distributed throughout the phylogenetic tree. The cold-adapted clade of Pseudomonas exhibited genome-wide signatures of adaptation and possessed clade-specific genes. This indicates that there are diverse evolutionary patterns in the divergence of cold-adapted species among different bacterial genera.
Analysis of the Impact of Knowledge on Sustainable Travel Choices: an Empirical Study with Informational Videos and Gamified Quizzes
Authors: Murad Syed , Law Effie Lai-Chong 
Published: December 2024

Abstract
Carbon emissions from transport are increasing on a global scale with transport accounting for the largest portion. While there is greater awareness of climate change, few people are willing to change their travel habits. To gain a better understanding of this phenomenon, we were motivated to conduct a study to identify the obstacles encountered by travellers when opting for sustainable transport modes, assess their knowledge of carbon emissions from various transport modes and explore how this knowledge affects their decision-making process. The study employed mixed-method approaches, including the use of informational videos and gamified quizzes for intervention, pre- and post-intervention knowledge assessment tests, semi-structured interviews, observations, Self-Assessment Manikin for emotion measures and card sorting. The findings primarily derived from thematic analysis indicated that knowledge-based intervention can be a strong catalyst to encourage sustainable attitude and behaviour change. Insights so gained have important theoretical and practical implications for designing sustainable behaviour change in the future, especially the deployment of persuasive technology.
Temocillin efficacy against AmpC β-lactamase-producing Enterobacterales: a relevant alternative to cefepime?
Authors: Brousse Xavier , Andry Fanny , Lahouati Marin , Desmoulin Anissa , Lehours Philippe , Rignol Laurine , Petitgas Paul , Leroy Anne-Gaëlle , Charroyer Quentin 
Published: December 2024

Abstract

Introduction
Temocillin is a semi-synthetic β-lactam with a narrow spectrum but high stability against hydrolysis by β-lactamases, including AmpC. Despite its favourable properties, data regarding its clinical value in the treatment of AmpC β-lactamase-producing Enterobacterales (ABPE) infections are scarce. Most recent guidelines do not include temocillin in the therapeutic strategy for ABPE infection.

Objectives
This study investigated (i) the proportion of ABPE isolates susceptible to temocillin and (ii) the clinical outcomes of patients treated with temocillin for ABPE infections.

Materials and Methods
This retrospective multicentre (Bordeaux and Reunion Island) study was performed in two parts. First, all the antimicrobial susceptibility test (AST) results of ABPE isolated from May 2021 to August 2023 were included in the analysis. Second, all patients who had received at least one dose of temocillin for ABPE infection between 2017 and 2023 were analysed. The electronic clinical records of these patients were reviewed to determine their treatment outcomes. Therapeutic success was defined as the absence of relapse one month after the end of temocillin treatment (3 months in the case of bone and joint infection) and the absence of treatment modification following an unfavourable outcome.

Results
During the microbiologic period of investigation (2021–23), 5166 ABPE strains were included. Of these, 4253 (82%) were susceptible to temocillin, whereas 4564 (88%) were susceptible to cefepime. After restriction to third-generation cephalosporin-resistant (3GCR) ABPE strains (n = 1446), the proportion of strains susceptible to temocillin was 66% (n = 1227) versus 59% (n = 1092) for cefepime. Temocillin treatment was initiated in 67 patients with ABPE infection during the study period (2017–23). The main infections were complicated urinary tract infections (n = 32, 48%) and bone and joint infections (n = 15, 22%). The estimated overall success rate for patients who underwent complete follow-up was 89% (n = 56/63).

Conclusions
Temocillin appears to be reliable for ABPE infections. Our data showed a high therapeutic success rate. Its high tolerability, narrow spectrum and ease of administration could make temocillin a relevant alternative to cefepime, the current standard for ABPE infection.
A New Conceptual Framework for African Sovereign Debt: Finding an Optimal Outcome that Addresses Five Challenges
Authors: Bradlow Daniel 
Published: December 2024

Abstract
The current arrangements through which African sovereigns raise and manage the external finance for sustainable and inclusive development in their countries are functioning sub-optimally. This troubling situation suggests that Africa needs a new approach to managing its sovereign debt and to restructuring the debt when servicing it becomes too burdensome. This paper argues that Africa is currently facing five challenges in regard to its sovereign debt and that addressing them requires a new conceptual framework that facilitates reaching an Optimal Outcome. This is defined as an outcome that, taking into account the circumstances in which the sovereign debtor and its creditors are negotiating their transaction and their respective rights, obligations and responsibilities, offers each of them the best possible mix of economic, financial, environmental, social, human rights and governance benefits.To make this case, the paper will focus on the case of sovereign debt restructurings. These transactions most clearly demonstrate the complexities and the challenges involved in reaching an Optimal Outcome in sovereign debt transactions. The paper is divided into 3 sections. The first section focuses on the five challenges that African countries are facing in managing and, when necessary, restructuring their sovereign debts. The second proposes eight principles, the DOVE (Debts of Vulnerable Economies) Fund Principles, that together offer a new conceptual framework for negotiating and drafting both new and restructured sovereign debt agreements. This new framework will help the sovereign and its creditors reach an Optimal Outcome. The third section draws some conclusions.
Loss-of-function of DDR1 is responsible for a chondrodysplasia with multiple dislocations
Authors: Villegas Villarroel Miriam , Huber Céline , Baujat Geneviève , Bonnard Adeline , Collet Corinne , Cormier-Daire Valérie 
Published: December 2024

Abstract
Chondrodysplasias with multiple dislocations are rare skeletal disorders characterized by hyperlaxity, joint dislocations, and growth retardation. Chondrodysplasias with multiple dislocations have been linked to pathogenic variants in genes encoding proteins involved in the proteoglycan (PG) biosynthesis. In this study, by exome sequencing analysis, we identified a homozygous nonsense variant (NM_001297654.2: c.1825C&gt;T, p.Arg609*) in the discoidin domain receptor 1 (DDR1) gene in a patient presenting joint dislocations, hyperlaxity, and cerebellar hypoplasia. Functional studies revealed decreased PG production in patient fibroblasts. We further demonstrated that DDR1 inhibition impaired the Indian Hedgehog signaling pathway in chondrocytes, decreased differentiation and mineralization in osteoblasts, and disrupted p38 MAPK signaling in both cell types. Additionally, we showed that DDR1 inhibition affected the noncanonical WNT signaling pathway in human skeletal cells and decreased PG production in chondrocytes. These findings suggest that DDR1 is a new gene involved in the group of chondrodysplasias with multiple dislocations and highlights its essential role in human skeletal and brain development.
Development of a new primer cocktail for improved DNA barcoding of brachyuran crabs (Decapoda: Brachyura)
Authors: Yoon Moongeun , Woo Jiyoung , Lee Sang-Hui , Kim Keun-Yong , Heo Jung Soo , Jo So Eun , Tran Biet Thanh 
Published: December 2024

Abstract
DNA barcoding has revolutionized species identification and molecular phylogeny, offering immense potential for elucidating the diversity of brachyuran crabs. We explored the utility of a new primer cocktail-based approach for amplifying DNA barcode regions of mitochondrial cytochrome c oxidase I (CO1) from 28 specimens representing brachyuran species across 21 major families collected along the Korean coast. The primer cocktail, comprising three forward and two reverse degenerate primers with M13 adapter tails, exhibited superior PCR amplification efficiency, being 100% successful. Sequencing of the PCR products yielded high-quality, 726 bp, DNA barcode sequences, facilitating accurate species identification with 23 out of 28 specimens matching precisely with their morphological taxonomy. Barcoding gap analysis revealed a clear gap between mean intra- and interspecific K2P distances, with a 148-fold difference, confirming the reliability of CO1 barcodes for achieving 100% success in species identification within the dataset. The study highlights the effectiveness and reliability of the new primer cocktail as a robust molecular marker for DNA barcoding of brachyuran crabs, essential for ecological investigations and conservation endeavors, and elucidating the taxonomic complexities among them.
Use of Polymerase Chain Reaction to Characterize the Etiology of Culture-Negative Empyema and Parapneumonic Effusion Among Alaska Native Children—2018-2023
Authors: Steinberg Jonathan , DeByle Carolynn , Westley Benjamin , Gotcsik Marah , Geis Jesse , Velusamy Srinivasan , Fischer Marc 
Published: December 2024

Abstract
We used polymerase chain reaction (PCR) to identify bacterial infections in culture-negative pleural fluid specimens from Alaska Native children hospitalized with empyema. PCR identified ≥1 organism in 11 (79%) of 14 specimens. Streptococcus pneumoniae serotype 3 was detected in 6 specimens; all 6 participants had received 13-valent pneumococcal conjugate vaccine.
Effect of nebivolol on erectile function: a systematic review and meta-analysis of randomized controlled trials
Authors: Lu Youyi , Li Lin , Li Qi , Sun Guoqin 
Published: December 2024

Abstract

Background
Historically, β-blockers have been associated with erectile dysfunction (ED). Nebivolol, a third-generation β-blocker, may have had no negative effect on erectile function because of its vasodilating properties. However, the evidence level was considered either as low or very low.

Aim
A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effect of nebivolol on erectile function.

Methods
All published RCTs were searched through PubMed, Cochrane Library, Web of Science, and Embase until October 2023. Review Manager version 5.3.0 was used for statistical analysis. Sensitivity analyses were performed by excluding each study using Stata 17 software.

Outcomes
The primary outcome was the International Index of Erectile Function (IIEF)-5 score. We excluded publication types, including letters, reviews, and meta-analyses.

Results
We identified four RCTs in this meta-analysis. All included studies compared the effects of nebivolol vs metoprolol on erectile function. Eight parallel groups with 397 individuals reported IIEF-5 scores. A random-effect model revealed that the IIEF-5 score was significantly higher in the nebivolol group (MD 1.81, 95%CI 0.95-2.68, P &lt; .0001, I2 = 99%). We conducted a sensitivity analysis by removing each individual study and observed that there was no significantly different result. Furthermore, we conducted a prespecified subgroup analysis based on the dosage of metoprolol, patients with ED at the time of enrollment, and disease type. Subgroup analysis revealed that heterogeneity significantly decreased, and the result of the IIEF-5 score was stable and consistent.

Clinical Implications
Our results provides stronger evidence that nebivolol significantly reduced the risk of ED occurrence or progression.

Strengths and Limitations
Our meta-analysis included high-quality RCTs and conducted a predetermined subgroup analysis. However, the main limitations are the limited number of included studies and their heterogeneity.

Conclusion
Our meta-analysis provided stronger evidence that nebivolol significantly reduced the risk of ED occurrence or progression compared with metoprolol, irrespective of whether the patient had ED or not. This meta-analysis could serve as an important reference for future studies in this field.
Quantitative Determination of High-Frequency Voltage Attenuation in an Electric-Pulse-Excited Stroboscopic Transmission Electron Microscope
Authors: Zhu Feng , Li Wanpeng , Yeung Man Chun , Zhang Yuxuan , Du Congcong , Lin Bin , Wang Qi , Guo Xiaofeng , Hsueh Yu-Chun , Chen Fu-Rong , Zhong Xiaoyan 
Published: December 2024

Abstract
High-frequency electric pulse signals are often applied to stimulate functional materials in devices. To investigate the relationship between materials structure and dynamic behavior under high-frequency electric excitation, the stroboscopic imaging mode is widely used in a transmission electron microscope (TEM). From a technical point of view, it is crucial to quantitatively determine high-frequency attenuation in an electric-pulse-excited stroboscopic TEM. Here, we propose the quantitative method to evaluate the voltage attenuation by using magnification variation of defocused bright-field transmission electron microscopy images in a stroboscopic mode when applying high-frequency electric pulse signals onto a model system of two opposite tungsten tips. The negative voltage excitation possesses higher high-frequency voltage attenuation than the positive voltage excitation due to the possible nonreciprocal transmission of the triangle waves within the circuit between the biasing sample holder and the arbitrary waveform generator. Our approach of high-frequency attenuation determination provides the experimental foundation for quantitative analysis on the dynamic evolution of materials structure and functionality under electric pulse stimuli.
VGLL fusions define a new class of intraparenchymal central nervous system schwannoma
Authors: Schmid Simone , Mirchia Kanish , Tietze Anna , Liu Ilon , Siewert Christin , Nückles Jakob , Schittenhelm Jens , Behling Felix , Snuderl Matija , Hartmann Christian , Brandner Sebastian , Paine Simon M L , Korshunov Andrey , Hasselblatt Martin , Coras Roland , Epari Sridhar , Stadelmann Christine , Zechel Sabrina , Simon Michèle , Wilson Yelena , Gianno Francesca , Lucas Calixto-Hope G , Zherebitskiy Viktor , Kaimaktchiev Vassil B , Robinson Lorraina , Aldape Kenneth , Hoving Eelco W , Tops Bastiaan B J , Perera Ashwyn Augustine , Göller Pauline , Hernáiz Driever Pablo , Wesseling Pieter , Koch Arend , Perry Arie , Sahm Felix , Jones David T W , Capper David 
Published: December 2024

Abstract

Background
Intracerebral schwannomas are rare tumors resembling their peripheral nerve sheath counterparts but localized in the central nervous system (CNS). They are not classified as a separate tumor type in the 2021 World Health Organization classification. This study aimed to compile and characterize these rare neoplasms morphologically and molecularly.

Methods
We analyzed 20 tumor samples by histology, RNA next-generation sequencing, DNA-methylation profiling, copy number analyses, and single-nucleus RNA sequencing (snRNA-seq). Clinical data, including age, sex, and disease progression, were collected. Magnetic resonance imaging (MRI) series were included when available.

Results
All cases with tissue available for histology review (n = 13) were morphologically consistent with intracerebral schwannoma, but differed in their extent of glial fibrillary acidic protein staining. All (n = 20) shared DNA-methylation profiles distinct from other CNS tumors, as well as from Vestigial-like family (VGLL)-altered peripheral nerve sheath tumors. Most cases (n = 14/17) harbored fusions of either Vestigial-like family member 3 (VGLL3) or Vestigial-like Family member 1 (VGLL1) (CHD7::VGLL3 [n = 9/17] and EWSR1::VGLL1 [n = 5/17]). In 2 cases, the presence of a VGLL3 fusion was also confirmed by copy number analyses (n = 2/17). MRI (n = 4) showed well-defined, nodular tumors with strong, homogeneous enhancement and no diffusion restriction. Tumors were located throughout the neuroaxis (supratentorial [n = 15], infratentorial [n = 4], and spinal [n = 1]). snRNA-seq of a VGLL1-fused tumor indicated VGLL1 upregulation in 28.6% of tumor cells (n = 1). During a median follow-up of 1.8 years (range 3 months-9 years), none of the tumors recurred (n = 10).

Conclusions
We identify and define a new benign tumor class, designated VGLL-altered intraparenchymal CNS schwannomas. These tumors feature VGLL alterations and a specific DNA-methylation profile, with schwannoma-like histopathology and CNS localization, akin to previously classified intracerebral schwannomas.