bluuebunny/crossref_metadata_2025_split huggingface dataset:
Training New Research Trainers: an Open Science and Medical Education Innovative Experience
Authors: Yabrude Angela Theresa Zuffo , Campos Letícia Nunes , Medeiros Samantha Sartore Duque Estrada , Custódio Clarissa Garcia , de Abreu Richardson Chaves , de Freitas Sarah Laís Silva , Cunha Moises da Costa , Hoshino Hillary Sayuri Ramires , Silva Barbara de Almeida Sena da , Ribeiro Lucas Loiola Ponte Albuquerque , Camargo Cristina Pires 
Published: June 2021

Abstract
Introduction: Open science is a valuable path to boost the global potential of scientific research by removing barriers for producing, disseminating, and putting science into practice, with the spirit of collaboration, inclusivity and focusing on communities’ rising demands. Open science principles instigate the management of scientific knowledge and the enhancement of abilities such as research, project management, team-building skills, and numerous others, which are essential for medical practice according to international recommendations, although still underexplored by medical schools.Methods: Open science, peer education, student leadership and developing of scientific skills were cornerstones to promote the Training New Research Trainers, the first edition of a national Brazilian student-led online workshop aiming to capacitate medical students in such targeted competencies and abilities through active teaching and learning methodologies.Results: Despite the challenges of online format, as impairment in some dynamics and assessment methods, it improved the access to the event from all Brazilian regions, totaling 409 submissions. Thus, it was necessary to have a previous selection of participants and adjustments in the workshop to assist twice the expected attendants.Discussion and Conclusions: Training New Research Trainers surpassed the national distribution inequalities of research opportunities and resources; mirrored open science bases in terms of access, education and methodology; and showed to be a promising opportunity for students to be protagonists of their learning process and to contribute to future changes in their reality, especially regarding the public health landscape. Improvements and consolidation of the workshop protocol and its expansion through national and international partnerships are the following goals.
Functionally prioritised whole-genome sequence variants improve the accuracy ofgenomic prediction for heat tolerance
Authors: Cheruiyot Evans K. , Haile-Mariam Mekonnen , Cocks Benjamin G. , MacLeod Iona M. , Mrode Raphael , Pryce Jennie E. 
Published: June 2021

Abstract
Background

Heat tolerance is a trait of economic importance in the context of warm climates and the effects of global warming on livestock, production, reproduction, health, and well-being. It is desirable to improve the prediction accuracy for heat tolerance to help accelerate the genetic gain for this trait. This study investigated the improvement in prediction accuracy for heat tolerance when selected sets of sequence variants from a large genome-wide association study (GWAS) were incorporated into a standard 50k SNP panel used by the industry.
Methods

Over 40,000 dairy cattle (Holsteins, Jersey, and crossbreds) with genotype and phenotype data were analysed. The phenotypes used to measure an individual’s heat tolerance were defined as the rate of milk production decline (slope traits for the yield of milk, fat, and protein) with a rising temperature-humidity index. We used Holstein and Jersey cows to select sequence variants linked to heat tolerance based on GWAS. We then investigated the accuracy of prediction when sets of these pre-selected sequence variants were added to the 50k industry SNP array used routinely for genomic evaluations in Australia. We used a bull reference set to develop the genomic prediction equations and then validated them in an independent set of Holsteins, Jersey, and crossbred cows. The genomic prediction analyses were performed using BayesR and BayesRC methods.
Results

The accuracy of genomic prediction for heat tolerance improved by up to 7%, 5%, and 10% in Holsteins, Jersey, and crossbred cows, respectively, when sets of selected sequence markers from Holsteins (i.e., single-breed QTL discovery set) were added to the 50k industry SNP panel. Using pre-selected sequence variants identified based on a combined set of Holstein and Jersey cows in a multi-breed QTL discovery, a set of 6,132 to 6,422 SNPs generally improved accuracy, especially in the Jersey validation set. Combining Holstein and Jersey bulls (multi-breed) in the reference set improved prediction accuracy compared to using only Holstein bulls in the reference set.
Conclusion

Informative sequence markers can be prioritised to improve the genetic prediction of heat tolerance in different breeds, and these variants, in addition to providing biological insight, have direct application in the development of customized SNP arrays or can be utilised via imputation into current SNP sets.
Binding Affinities of Sanggenon Derivatives as PTP1B Inhibitors; Using Molecular Dynamics and Free Energy Calculations
Authors: KOCAKAYA Safak OZHAN 
Published: June 2021

Abstract
Recently, protein tyrosine phosphatase 1B (PTP1B) inhibitors have become the frontier as possible targeting for anti-cancer and antidiabetic drugs. The contemporary observe represents a pc assisted version to investigate the importance of precise residues within the binding web site of PTP1B with numerous Sanggenon derivatives remoted from nature. Molecular dynamics (MD) simulations were performed to estimate the dynamics of the complexes, and absolute binding unfastened energies have been calculated with exclusive additives, and carried out through the usage of the Molecular Mechanics-Poisson-Boltzmann floor region (MM-PB/SA) and Generalized Born surface vicinity (MM-GB/SA) strategies. The effects show that the expected free energies of the complexes are normally constant with the available experimental statistics. MM/GBSA free energy decomposition analysis shows that the residues Asp29, Arg24, Met258, and , Arg254 in the second active site in PTP1B are crucial for the excessive selectivity of the inhibitors.
A MICROFLUIDIC CHIP FOR PULMONARY ARTERIAL HYPERTENSION
Authors: Wojciak-Stothard Beata , Ainscough Alexander , Smith Timothy , Rhodes Christopher , Fellows Adam , Howard Luke , Wharton John , Wilkins Martin , Edel Joshua 
Published: June 2021

Abstract
Pulmonary arterial hypertension (PAH) is an unmet clinical need. The lack of a disease model representative of the human condition is a key obstacle to the development of new treatments. Here we present a model of PAH, based on a biomimetic pulmonary artery (PA)-on-a-chip, that permits the study of the molecular and functional changes in human pulmonary vascular endothelial and smooth muscle cells in response to triggers of the disease and their response to drugs. We combine natural or induced BMPR2 dysfunction with hypoxia in vascular endothelial cells to trigger smooth muscle activation and proliferation and relate accompanying transcriptomic changes in affected cells to functional effects. Changes in gene expression consistent with observations made in genomic and biochemical studies of the human disease enable insights into underlying disease pathways and mechanisms of drug response. The model offers a novel, promising and more easily accessible approach for researchers to study pulmonary vascular remodelling and advance drug development in PAH.
Cyanobacterial biomass: a striking factor to decrease polyaluminium chloride (PACl) coagulation efficiency during a successive bloom
Authors: Song Weijun , Zeng Jie , Li Xi , Xie Yu , Wu Xunfang 
Published: June 2021

Abstract
Occurrence of cyanobacterial blooms in source waters challenges water treatment processes. During a successive bloom, typical characteristics of elevated cell-density and pH were observed from development to maintenance stage. However, studies about their influences on the coagulation process have been limited. Here, PACl coagulation experiments were conducted to investigate Microcystis removal with varied pH and cell-density. Results showed that PACl coagulation alone was sufficient to remove Microcystis with low cell-density (105–106 cells mL−1), since an elevated pH value (8.5–9.5) can promote PACl coagulation, possibly ascribed to sweeping cells via neutral gelatinous precipitate of alum. Nevertheless, elevated cyanobacterial biomass was a striking factor in decreasing Microcystis removal (80%–100%) by PACl coagulation, since its inhibitory effects on the coagulation process could not be offset by in situ elevated pH value. Chlorination-assisted (1 mg L−1) coagulation was recommended to treat cyanobacteria-laden source waters with high cell-density of &gt;107 cells mL−1, as it promoted cyanobacterial removal and achieved the highest removal ratio of DOC and turbidity among these treatments. These findings will provide an important reference for water supplies to choose the proper water treatment process to treat cyanobacteria-laden source waters during a successive bloom.
Synthesis, Electronic Structure and Anti-Cancer Activity of the Phenyl Substituted Pyrazolo[1,5-a][1,3,5]triazines
Authors: Velihina Evgenia S. , Obernikhina Nataliya V. , Pilyo Stepan G. , Kachkovsky Oleksiy D. , Brovarets Volodymyr S. 
Published: June 2021

Background:
Synthesis of a series of 2-(dichloromethyl)pyrazolo[1,5-
a][1,3,5]triazines was carried out and evaluated in vitro for their anticancer activity against a
panel of 60 cell lines derived from nine cancer types.

Methods:
The joint quantum-chemical and experimental study of the influence of the extended
πconjugated phenyl substituents on the electron structure of the pyrazolo[1,5-
a][1,3,5]triazines as Pharmacophores were performed. It is shown that the decrease in the
barriers to the rotation of phenyl substituents in compounds 1-7 possibly leads to an increase
in the anti-cancer activity, which is in agreement with the change in the parameter biological
affinity Φ0. Analysis of the S0 → S1 electronic transitions (π→π*) of the pyrazolo[1,5-
a][1,3,5]triazines shows that an increase in their intensity correlates with anti-cancer activity.

Results:
Thus, the introduction of phenyl substituents increases the likelihood of investigated
pyrazolo[1,5-a][1,3,5]triazines interacting with protein molecules (Biomolecule) by the π-stacking mechanism. In
both methyl and phenyl derivatives of pyrazolo[1,5-a][1,3,5]triazines, the second electronic transition includes the n-
MO (the level of the lone electron pair in two-coordinated nitrogen atoms). The highest intensity of the η→π* electronic
transition is observed in pyrazolo[1,5-a][1,3,5]triazine with pyridine residue, which does not exhibit anticancer
activity, but exhibits antiviral activity [13].

Conclusion:
It can be assumed that the possibility of the formation of [Pharmacophore-Biomolecule] complex by
hydrogen bonding ([H-B]) mechanism with protein molecules increases.
Thermostable α-Glucan Phosphorylase-catalyzed Enzymatic Chain-elongation to Produce 6-Deoxygenated α(1γ4)-Oligoglucans
Authors: Kadokawa Jun-ichi , Lee Le Hooi , Yamamoto Kazuya 
Published: June 2021

:
Herein, the synthesis of 6-deoxygenated α(1γ4)-oligoglucans via thermostable αglucan phosphorylase (from Aquifex aeolicus VF5)-catalyzed enzymatic chain-elongation is
reported from a maltotriose primer using a non-native substrate, 6-deoxy-α-D-glucose 1-
phosphate. The enzymatic reaction of the two substrates mainly produced a tetrasaccharide
with one 6-deoxy-α-D-glucose unit at the non-reducing end, together with a minor pentasaccharide with two 6-deoxy-α-D-glucose units. The enzymatic chain-elongation from the primer
in the presence of 6-deoxy-α-D-glucose 1-phosphate and a native substrate, α-D-glucose 1-
phosphate, afforded 6-deoxygenated α(1γ4)-oligoglucans with varying degrees of polymerization. This enzymatic chain-elongation catalyzed by thermostable α-glucan phosphorylase is
an efficient method to produce non-natural oligosaccharides, that is, 6-deoxygenated α(1γ4)-
oligoglucans.
Polarity Effect on the Electronic Structure of Molybdenum Dichalcogenides MoXY (X, Y = S, Se): A Computational Study Based on Density-Functional Theory
Authors: Putri Salsabila Amanda , Suharyadi Edi , Absor Moh. Adhib Ulil 
Published: June 2021

Computational research based on the Density Functional Theory (DFT) has been performed to explore the electronic structure of monolayer material Transition Metal Dichalcogenides (TMDCs) Molybdenum Dichalcogenides MoXY (X; Y = S; Se) in the first Brillouin zone by breaking its mirror symmetry due to the polarity effect. Our study discovered that Rashba spin-splitting could be identified around the Γ point by proposing the polarity effect on the system. Moreover, the anisotropic characteristic of Rashba spin-splitting in this system can be explicitly analyzed by using perturbation theory and the third-order symmetry group analysis. By performing the spin textures analysis, this research also recognizes the in-plane direction of spin textures. The tunable characteristic of the Rashba parameter of this monolayer polar MoSSe system under the strain effects control exhibits its potential to be the candidate of semiconductor material for the Spin Field Effect Transistor (SFET) device.
Diagonal Based Feature Extraction and Backpropagation Neural Network in Handwritten Batak Toba Characters Recognition
Authors: Zamzami Elviawaty Muisa , Hayanti Septi , Nababan Erna Budhiarti 
Published: June 2021

Handwritten character recognition is considered a complex problem since one’s handwritten character has its characteristics. Data used for this research was a photo of handwritten or scanned handwritten. In this research, Backpropagation Neural Network (BPNN) was used to recognize handwritten Batak Toba character, wherein preprocessing stage feature extraction was done using Diagonal Based Feature Extraction (DBFE) to obtain feature value. Furthermore, the feature value will be used as an input to BPNN. The total number of data used was190 data, where 114 data was used for the training process and another 76 data was used for testing. From the testing process carried out, the accuracy obtained was 87,19 %.
Experiment of Path Planning Using Multi-way Points with A* Algorithm for Autonomous Surface Vehicle
Authors: Erfianto Bayu , Adrianne Adysti , Arif Ramzy Rashaun 
Published: June 2021

Commonly, surveillance activities on lake waters is mostly carried out by using a surface vehicle as special-designed vehicle, especially to conduct water quality measurements, underwater surveys, and bathymetry mapping. However, conventional survey and monitoring still involves humans on the site. If a survey is conducted during strong wind conditions, it could jeopardize surveyor’s safety. Therefore, a vehicle must have several criteria, e.g., it must be pretty spacious and comfortable to carry surveyors, free from engine vibrations, stabilized and easy to maneuver, and the surveyor's safety can be guaranteed. This paper discusses preliminary research aiming to develop an Autonomous Raft Vehicle (ARV), a type of autonomous unmanned surface vehicle. The ARV is equipped with autonomous control based on multi-way-points with an A* algorithm. Thus, a user only requires giving a command once initially during path planning. A* algorithm over multi-way-point could improve ARV navigation when there are obstacles along the predetermined trajectory. Hence the predetermined trajectory will be maintained throughout the mission. It is a significant contribution to this paper.
THEORETICAL REVIEW OF ISLAMIC LEGAL SOURCES ACCORDING TO THE MISREPRESENTATION THEORY OF HALLAQ
Authors: Budiman Rahmat 
Published: June 2021

The existence of Islamic law from time to time in a Muslim community is believed to be the result of an in-depth study of the sources of Islamic law: the Qur’an (the Word of God), Hadith (sayings of the Prophet Muhammad), Ijtihad (the process of making a legal decision by independent interpretation of the legal sources, the Qur’an and the Sunnah), Qiyas (the deduction of legal prescriptions from the Qur’an or Sunnah by analogic reasoning), as well as Ijma (the result of the agreement of the Scholars). These sources of Islamic law were then poured into Usul al-Fiqh, which was then considered as a concrete form of Islamic law itself. This is reinforced by the classical teachings of orientalist Scholars who acknowledge that Islamic law is preserved in Usul al-Fiqh by great Scholars. However, this concept was challenged by Hallaq with a misrepresentation of his theory. He stated that Sharia can exist in society, not because of the role of Usul al-Fiqh but the role of the Fatwa (authoritative legal opinion), which is given by the Mufti and is applied by practitioners of Islamic law in Muslim-majority societies.
Is the Consensual Threshold for Defining High Glucose Variability Implementable in Clinical Practice?
Authors: Julla Jean-Baptiste , Jacquemier Pauline , Fagherazzi Guy , Vidal-Trecan Tiphaine , Juddoo Vanessa , Jaziri Asma , Mersel Hanane , Venteclef Nicolas , Roussel Ronan , Massin Pascale , Couturier Aude , Gautier Jean-François , Riveline Jean-Pierre 
Published: June 2021

OBJECTIVE
Estimating glycemic variability (GV) through within-day coefficient of variation (%CVw) is recommended for patients with type 1 Diabetes (T1D). High GV (hGV) is defined as %CVw &gt; 36%. However, continuous glucose monitoring (CGM) devices provide exclusively total CV (%CVT). We aimed to assess consequences of this disparity.

RESEARCH DESIGN AND METHODS
We retrospectively calculated both %CVT and %CVw of consecutive T1D patients from their CGM raw data during 14 days. Patients with hGV with %CVT &gt;36% and %CVw ≤36% were called the “inconsistent GV group”.

RESULTS
A total of 104 patients were included. Mean ± SD %CVT and %CVw were 42.4 ± 8% and 37.0 ± 7.4% respectively (P &lt; 0.0001). Using %CVT, 81 patients (73.6%) were classified as having hGV, whereas 59 (53.6%) using %CVw (P &lt; 0.0001) corresponding to 22 patients (21%) in the inconsistent GV population.

CONCLUSIONS
Evaluation of GV through %CV in patients with T1D is highly dependent on the calculation method and then must be standardized.
Accuracy of Dexcom G6 Continuous Glucose Monitoring in Non–Critically Ill Hospitalized Patients With Diabetes
Authors: Davis Georgia M. , Spanakis Elias K. , Migdal Alexandra L. , Singh Lakshmi G. , Albury Bonnie , Urrutia Maria Agustina , Zamudio-Coronado K. Walkiria , Scott William H. , Doerfler Rebecca , Lizama Sergio , Satyarengga Medha , Munir Kashif , Galindo Rodolfo J. , Vellanki Priyathama , Cardona Saumeth , Pasquel Francisco J. , Peng Limin , Umpierrez Guillermo E. 
Published: June 2021

OBJECTIVE
Advances in continuous glucose monitoring (CGM) have transformed ambulatory diabetes management. Until recently, inpatient use of CGM has remained investigational, with limited data on its accuracy in the hospital setting.

RESEARCH DESIGN AND METHODS
To analyze the accuracy of Dexcom G6, we compared retrospective matched-pair CGM and capillary point-of-care (POC) glucose data from three inpatient CGM studies (two interventional and one observational) in general medicine and surgery patients with diabetes treated with insulin. Analysis of accuracy metrics included mean absolute relative difference (MARD), median absolute relative difference (ARD), and proportion of CGM values within 15, 20, and 30% or 15, 20, and 30 mg/dL of POC reference values for blood glucose &gt;100 mg/dL or ≤100 mg/dL, respectively (% 15/15, % 20/20, % 30/30). Clinical reliability was assessed with Clarke error grid (CEG) analyses.

RESULTS
A total of 218 patients were included (96% with type 2 diabetes) with a mean age of 60.6 ± 12 years. The overall MARD (n = 4,067 matched glucose pairs) was 12.8%, and median ARD was 10.1% (interquartile range 4.6, 17.6]. The proportions of readings meeting % 15/15, % 20/20, and % 30/30 criteria were 68.7, 81.7, and 93.8%, respectively. CEG analysis showed 98.7% of all values in zones A and B. MARD and median ARD were higher in the case of hypoglycemia (&lt;70 mg/dL) and severe anemia (hemoglobin &lt;7 g/dL).

CONCLUSIONS
Our results indicate that CGM technology is a reliable tool for hospital use and may help improve glucose monitoring in non–critically ill hospitalized patients with diabetes.
INTERTEXTUALITY REALIZATION IN SARI MATUA CEREMONY
Authors: Hutagalung Dyan Yosephin , Pulungan Anni Holila , Husein Rahmad . 
Published: June 2021

ABSTRACTThis study aims to describe the realization of intertextuality occurences in sari matua ceremony. This research is conducted qualitatively by applying technique analysis of Bazerman. The data are utterances which delivered by the speakers in the ceremony and transcribed into transcription. Sari Matua is one kind of death ceremony in batak toba culture and has been studied in other particular field of study. In this study, intertextuality occurrence are studied on oral discourse in Sari matua batak toba ceremony. Sari matua batak toba ceremony consisted of two sessions which are Martonggo Raja and main ceremony and this study focuses on these two sessions. The result of this study shows that there were 50 specific data found from 82 specific data which included kinds of intertextuality namely qutotation, reference, and allusion. The realization of intertextuality occurences in sari matua Batak Toba ceremony is realized by some elements of intertextuality itself. The realization Quotation is identified through the presence of lexical expressions such as mandok, manungkun, hatahononku, di dok, pinasihat. Reference is identified by seeing clause which reflected to, re-contextualized to dan re-accentuated to. Allusion is identified by clause complex which referring the text to literature, historical art, story, person even place. The intertextuality occurences realized in sari matua Batak Toba ceremony because the text which quoted, referred to and alluded to from the past time can be reflected in ourlives in the present time. Key words: Intertextuality, Oral Discourse, Batak Toba Ceremony, Sari Matua
REALIZATION OF INTERTEXTUALITY IN EDITORIALS OF PRESIDENTIAL ELECTION 2019
Authors: Hasibuan Elsi Revita , Pulungan Anni Holila , Murni Sri Minda 
Published: June 2021

ABSTRACTA text can be only interpreted through a background information of other text, and this is where intertextuality emerged, to shape another text. This study investigates the realization of intertextuality in articles of opposite editorials related to Presidential Election 2019. The objectives of the study is to evaluate the ways of the intertextuality realized. This research applied qualitative research design. The data were complex clauses which contained of intertextuality from opposite editorials of four newspapers, namely Kompas, Media Indonesia, Analisa, and Waspada started from January 2nd until April 17th 2019. The data were analyzed by using content analysis technique proposed by Elo and Kyngas (2007). The findings showed that; there were five elements those caused intertextuality realized in opposite editorials, they were; paraphrasing, patchwriting, making implicit meaning, putting contrastive conjunction, and last, image building. Keywords: Intertextuality, Realizations, Editorials, Presidential Election, Content Analysis