bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assess transmissibility of different influenza subtypes: Based on a SEIABR model
Authors: Dai Haoyun , Zhou Nan , Chen Mengxiang , Li Guoqun , Yi Shanghui , Hong Xiuqin , Quan Meifang , Zha Wen-Ting , Lv Yuan 
Published: May 2021

Abstract
Background: Influenza is a worldwide public health problem which causes a serious economic and health burden. In order to provide a scientific basis for improving the prevention and control level of influenza, using dynamic model to evaluate the infection rates of influenza different subtypes from 2010 to 2019 in China. Methods: This article established SEIABR model and calculated the infection rates of different influenza subtypes by using the Berkeley Madonna software. Results: The average infection rate of influenza was (7.95±1.27)×10-10 , and influenza A was (7.25±0.82) ×10-10, influenza B was (5.88±0.97)×10-10. In addition, the infection rates of A /H1N1, A/H3N2, B/Yamagata and B/Victoria were (7.25±0.82) ×10-10, (6.13±0.35) ×10-10, (6.01±0.52) ×10-10, (6.37±0.79) ×10-10. Conclusion: Between each year, flu transmission capacity had fluctuation. Influenza A was more transmissible than influenza B, and during the major subtypes, influenza A/H1N1 was the most transmissible.
A Case of Synchronous Serous Ovarian Cancer and Uterine Serous Endometrial Intraepithelial Carcinoma
Authors: Shimizu Maho , Yamanaka Keitaro , Azumi Maho , Tomimoto Masako , Washio Keiichi , Takahashi Ryosuke , Nagamata Satoshi , Murata Yuka , Yamasaki Yui , Terai Yoshito 
Published: May 2021

Abstract
BackgroundSerous endometrial intraepithelial carcinoma (SEIC) is now considered to represent an early stage of uterine serous carcinoma (USC). It is an intraepithelial lesion but has been reported to cause extrauterine metastases. We report a case of SEIC with serous ovarian carcinoma and lymph node metastasis.Case presentationA 57-year-old post-menopausal woman (gravida 3, para 2, SA1) was referred to our hospital with lower abdominal pain. An ultrasound and MRI showed that the ovary had swollen to 8 cm in size and had a solid lesion. The uterus was normal. The patient underwent exploratory laparoscopy on the suspicion of torsion of the ovarian tumor. Intraoperative findings showed a right ovarian tumor, but no ovarian tumor torsion was observed. A small amount of bloody ascites was found in the Douglas fossa, and bleeding was observed from the tumor itself. A right salpingo-oophorectomy was then performed. Histopathological results revealed a high-grade serous carcinoma. Forty days after the first surgery, we performed a staging laparotomy: a total abdominal hysterectomy, left salpingo-oophorectomy, systematic pelvic and paraaortic lymphadenectomy, and a partial omentectomy. A complete cytoreduction was achieved. In the pathological examination, the invasion of the serous carcinoma was observed in the left ovarian ligament, and lymph node metastasis was found in the paraaortic lymph nodes. Atypical columnar cells formed irregular papillary lesions which had proliferated in the endometrium, and this was diagnosed as SEIC. The final diagnosis was serous ovarian cancer, FIGO stage ⅢA1(ⅱ), pT2bN1M0, with SEIC. ConclusionWe report a case of SEIC with synchronous serous carcinoma of the adnexa uteri. Both were serous carcinomas and, thus, it was difficult to identify the primary lesion. The distinction between metastatic cancer and two independent primary tumors is important for an accurate diagnosis and tumor staging. Histological diagnostic criteria remain controversial, and further development of a method for differentiating between both diseases is required.
The Multidisciplinary Treatment of Advanced Gallbladder Cancer to Disease-Free Survival: A Case Report
Authors: Zhang Biao , Li Shuang , Liu Zhaoyi , Peiris Karieshinie Ghandalie Kalandika , Song Lifu , Liu Mucang , Luo Peng , Shang Dong , Bi Wei 
Published: May 2021

Abstract
Background: Gallbladder cancer is the most common malignant tumor in the biliary system and is characterized by strong aggressiveness and an extremely poor prognosis. Current treatment for advanced gallbladder cancer remains unsatisfactory. Here we reported a patient with stage IV gallbladder cancer who achieved disease-free survival by multidisciplinary treatment.Case presentation: A 73-year-old man presented to our hospital with right abdominal pain for 3 days and was diagnosed with advanced gallbladder cancer with multiple intrahepatic metastases and distant lymph node metastases. The patient initially received chemotherapy, targeted therapy, radioactive seed implantation, and immunotherapy as there was no specific indications for radical surgery. With the progression of these adjuvant therapies, the patient’s tumor makers gradually decreased but remained higher than normal, lymph node metastases gradually disappeared, and intrahepatic metastases were gradually limited to the left liver. Finally, the patient received a radical surgery of left hepatectomy with partial diaphragmatic resection and radical lymphadenectomy. To date, the patient has survived for more than six years post-treatment, and the level of tumor markers is normal and the imaging examination shows no signs of disease recurrence.Conclusion: The treatment of advanced gallbladder cancer remains pessimistic in the current medical arena. This successful case is an inspiration and we believe that multidisciplinary treatment can benefit patients with advanced gallbladder cancer and help them achieve long-term survival or even disease-free survival.
The Giant Parathyroid Adenoma Reaching Mediastinum: A Case Report
Authors: Mahmodlou Rahim , Sedokani Amin , Najafinejad Bita 
Published: May 2021

Abstract
Background: The primary hyperparathyroidism is the most common disease of parathyroid glands and the third common endocrine disease. Giant parathyroid adenoma is defined as weight > 3.5gr and size of > 2cm, however, the normal weight of the parathyroid gland is about 70mg to 1gr.Case Presentation: This report describes the most giant diagnosed primary parathyroid adenoma due to literature. The case is a 48-year-old Persian man with past medical history of mitral valve replacement and several episodes of bilateral nephrolithiasis. The chief complaints were knee and lower back pain. After complete assessment, the neck mass with possible origin of thyroid were detected and resected by surgery. The size of resected mass was 9×6×4cm weighting 122gr. The histopathological assessment revealed giant parathyroid adenoma.Conclusion: There are some reports of giant parathyroid adenoma describing the weight of up to 110gr leading to significant hypercalcemia with a size of 8cm. despite the size of the giant parathyroid adenomas and parathormone high levels, the calcium crisis may not always occur in these patients and the masses may be misdiagnosed with thyroid mass at primary assessments.
MRI Modality-based Brain Tumor Segmentation Using Deep Neural Networks
Authors: Kasar Pankaj Eknath , Jadhav Shivajirao M. , Kansal Vineet 
Published: May 2021

Abstract
The tumor detection is major challenging task in brain tumor quantitative evaluation. In recent years, owing to non-invasive and strong soft tissue comparison, Magnetic Resonance Imaging (MRI) has gained great interest. MRI is a commonly used image modality technique to locate brain tumors. An immense amount of data is produced by the MRI. Heterogeneity, isointense and hypointense tumor properties restrict manual segmentation in a fair period of time, thus restricting the use of reliable quantitative measures in clinical practice. In the clinical practice manual segmentation task is quite time consuming and their performance is highly depended on the operator’s experience. Accurate and automated tumor segmentation techniques are also needed; however, the severe spatial and structural heterogeneity of brain tumors makes automatic segmentation a difficult job. This paper proposes fully automatic segmentation of brain tumors using encoder-decoder based convolutional neural networks. The paper focuses on well-known semantic segmentation deep neural networks i.e., UNET and SEGNET for segmenting tumors from Brain MRI images. The networks are trained and tested using freely accessible standard dataset, with Dice Similarity Coefficient (DSC) as metric for whole predicted image i.e., including tumor and background. UNET’s average DSC on test dataset is 0.76 whereas for SEGNET we got average DSC 0.67. The evaluation of results proves that UNET is having better performance than SEGNET.
Numerical dissipation of flux splitting schemes for contact discontinuities
Authors: Liu Jun , Han Fang , Wei Yan Xin 
Published: May 2021

Abstract
The contact discontinuity is simulated by three kinds of flux splitting schemes to evaluate and analyse the influence of numerical dissipation in this paper. The numerical results of one-dimensional contact discontinuity problem show that if the flow velocity on both sides of the contact discontinuity is not simultaneously supersonic, the non-physical pressure and velocity waves may occur when the initial theoretically contact discontinuity is smeared into a transition zone spanning several grid-cells caused by numerical dissipations. Since these non-physical waves have no effect on the corresponding density dissipation, this paper considers these fluctuations as only numerical errors and are not part of the numerical dissipation. In addition, for two-dimensional flow field, the characteristics of high-order accuracy difference schemes, i.e. low dissipation and high resolution, may induce the multi-dimensional non-physical waves that interfere with each other to produce more complex non-physical flow structures, so the fluctuations in the calculated results should be treated with caution.
The Antioxidant tempol delays the MIA-induced osteoarthritis progression in rats via modulation of signaling pathways involving TGF-β1/SMAD3/NOX4 axis
Authors: Abo-zalam Hagar B. , Abdel-Rahman Rehab F. , Abd-Ellah Mohamed F. , Abdalsalam Rania M. , Khattab Mahmoud M. 
Published: May 2021

Abstract
Osteoarthritis (OA) is a complex disease characterized by structural, functional, and metabolic deteriorations of the whole joint and periarticular tissues. In the current study, we aimed to investigate the possible effects of tempol on knee OA induced by the chemical chondrotoxic monosodium iodoacetate (MIA) which closely mimics both the pain and structural changes associated with human OA. Rats were administrated oral tempol (100 mg/kg) one week post-MIA injection (3 mg/ 50 μL saline) at the right knee joints for 21 consecutive days. Tempol improved motor performance and debilitated the MIA-related radiological and histological alterations. Besides, it subsided the knee joint swelling. Tempol decreased the cartilage degradation-related biomarkers as matrix metalloproteinase-13, cartilage oligomeric matrix protein, and fibulin-3. The superoxide dismutase mimetic effect of tempol was accompanied by decreased NADPH oxidase 4 (NOX4), inflammatory mediators, nuclear factor kappa-B (NF-κB), over-released insulin-like growth factor-1 (IGF-1) and transforming growth factor-β1 (TGF-β1). Tempol decreased the expression of chemotactic cytokine ligand 2 (CCL2), dickkopf‑related protein-1 (DKK-1), and protein kinase C (PKC). On the molecular level, tempol reduced the phosphorylated protein levels of p38 mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K), protein kinase B (Akt), and small mother against decapentaplegic 3 homologs (SMAD3). These findings suggest the promising role of tempol in ameliorating MIA-induced knee OA in rats via collateral suppression of the catabolic signaling cascades including TGF-β1/SMAD3/NOX4, NOX4/p38MAPK/NF-κB, and PI3K/Akt/NF-κB and therefore modulation of oxidative stress, catabolic inflammatory cascades, chondrocyte metabolic homeostasis, autophagy, and cell survival.
Accurate localization of the symptomatic nerve roots of patients with adult degenerative scoliosis using diffusion tensor imaging
Authors: Wang Qian , Gao Peng , Tang Pengyu , Chen Jian , Zhao Shujie , Li Qingqing , Zhou Wei , Yin Guoyong , Fan Jin 
Published: May 2021

Abstract
Background: In the diagnosis and treatment of adult degenerative scoliosis (ADS), the localization of symptomatic nerve roots is mainly based on the symptoms and signs of patients. Because of spinal rotation deformity, conventional MRI cannot accurately select the level of intervertebral disc for scanning. In the present study, MR diffusion tensor imaging (DTI) was used to diagnose symptomatic nerve roots in patients with ADS, and its effectiveness was evaluated by comparing with diagnosis based on symptoms and signs of nerve root block. Methods: Thirty-six patients who were clinically diagnosed to have ADS underwent routine MRI and DTI examinations, and fractional anisotropy (FA) of each nerve root in the lumbar spine was quantitatively measured. The t-test was used to compare the FA values ​​of nerve roots with and without neurological symptoms. Preoperative and postoperative clinical evaluations were conducted on the patients, and the t-test was used to evaluate the clinical effects of surgery. Results: The FA values ​​of symptomatic and asymptomatic nerve roots were significantly different (P<0.01). The DTI findings of symptomatic nerve roots were consistent with the diagnosis based on symptoms and nerve root block. The Japanese Orthopaedic Association (JOA), Oswestry Disability Index (ODI), Visual Analog Scale-Back Pain (VAS-BP), and Visual Analog Scale-Leg Pain (VAS-LP) scores of the postoperative patients were significantly improved as compared to those in the preoperation stage; the Cobb, Lumbar Lordosis (LL), Pelvic Tilt (PT), and Sacral Slope (SS) angles were corrected significantly post operation. Conclusion: The FA value can be used as a marker for predicting symptomatic nerve root and is consistent with clinical symptoms. According to the results of DTI, precise nerve root decompression can relieve the symptoms. Therefore, DTI can be used as an effective auxiliary method for symptomatic nerve root localization in patients with degenerative scoliosis.
Predictors of Health Information–Seeking Behavior: Systematic Literature Review and Network Analysis
Authors: Mirzaei Ardalan , Aslani Parisa , Luca Edward Joseph , Schneider Carl Richard 
Published: May 2021

Background
People engage in health information–seeking behavior to support health outcomes, and being able to predict such behavior can inform the development of interventions to guide effective health information seeking. Obtaining a comprehensive list of the predictors of health information–seeking behavior through a systematic search of the literature and exploring the interrelationship of these predictors are critical first steps in this process.

Objective
This study aims to identify significant predictors of health information–seeking behavior in the primary literature, develop a common taxonomy for these predictors, and identify the evolution of the concerned research field.

Methods
A systematic search of PsycINFO, Scopus, and PubMed was conducted for all years up to and including December 10, 2019. Quantitative studies identifying significant predictors of health information–seeking behavior were included. Information seeking was broadly defined and not restricted to any source of health information. Data extraction of significant predictors was performed by 2 authors, and network analysis was conducted to observe the relationships between predictors with time.

Results
A total of 9549 articles were retrieved, and after the screening, 344 studies were retained for analysis. A total of 1595 significant predictors were identified. These predictors were categorized into 67 predictor categories, with the most central predictors being age, education, gender, health condition, and financial income. With time, the interrelationship of predictors in the network became denser, with the growth of new predictor grouping reaching saturation (1 new predictor identified) in the past 7 years, despite increasing publication rates.

Conclusions
A common taxonomy was developed to classify 67 significant predictors of health information–seeking behavior. A time-aggregated network method was developed to track the evolution of the research field, showing the maturation of new predictor terms and an increase in primary studies reporting multiple significant predictors of health information–seeking behavior. The literature has evolved with a decreased characterization of novel predictors of health information–seeking behavior. In contrast, we identified a parallel increase in the complexity of predicting health information–seeking behavior, with an increase in the literature describing multiple significant predictors.
Comparison of radioactivity and geochemistry of rocks from plutonic bodies adjacent to the southern part of Golfo of California
Authors: Fiala J. , Hanus V. , Vanek J. , Vankova V. 
Published: May 2021

La comparación de la composición modal y los contenidos de los elementos mayores, radioactivos (U, Th, K) y de elementos de traza seleccionados (Rb, Sr, Ba, Y, Zr, V, Cr, Ni) en las rocas graníticas de los complejos plutónicos de la región de Jalisco y Baja California Sur, apoya la idea de un cuerpo batolítico original separado más tarde por el proceso de abertura del Golfo de California.
Compassion satisfaction, burnout, and secondary traumatic stress among full-time veterinarians in the United States (2016–2018)
Authors: Ouedraogo Frederic B. , Lefebvre Sandra L. , Hansen Charlotte R. , Brorsen B. Wade 
Published: May 2021

Abstract

OBJECTIVE
To determine prevalences of low compassion satisfaction (CS), high burnout (BO), and high secondary traumatic stress (STS) scores among full-time US veterinarians and estimate effects of selected demographic, employment-related, and education-related factors on those scores.

SAMPLE
5,020 full-time veterinarians who participated in the 2016, 2017, and 2018 AVMA Census of Veterinarians surveys.

PROCEDURES
Data were obtained from census surveys regarding demographic, employment-related, and education-related factors, and scores assigned to items from a professional quality-of-life instrument designed to measure CS and compassion fatigue (ie, BO and STS) were compared between and among various demographic and employment groups.

RESULTS
Overall, 35.5% of veterinarians were classified as having low CS scores, 50.2% as having high BO scores, and 58.9% as having high STS scores. Controlling for other variables, high educational debt was associated with low CS, high BO, and high STS scores. Veterinarians who spent ≥ 75% of their time working with dogs or cats had higher BO and STS scores than did those who spent < 25% of their time. Veterinarians with more experience and higher annual incomes had higher CS scores and lower BO and STS scores. Women had higher BO and STS scores than did men, but no gender differences were observed in CS scores.

CONCLUSIONS AND CLINICAL RELEVANCE
Several variables were identified that may put veterinarians at higher risk than others for compassion fatigue and low CS. These findings may be useful in the development of resources and targeted initiatives to support and defend veterinarian well-being.
The Removal of a Fractured Guidewire During Mechanical Thrombectomy. A Case Report
Authors: Filep Rares Cristian , Bloj Andrei Florin , Marginean Lucian 
Published: May 2021

Abstract
Recent randomized controlled trials have transformed the treatment of acute ischemic stroke. Mechanical or aspiration thrombectomy is the main treatment option for occlusions of large intracranial vessels. Despite its high technical success rate, endovascular thrombectomy can sometimes be complicated by anatomical peculiarities or device failures. The most frequent complications are related to vessel dissection or vessel perforation by devices while navigating intricate anatomy. Rarer still are technical device failures, like spontaneous stent-retriever detachment, which occurred with older generation retrievers. This case reports a rare device failure, which, to the best of our knowledge, has not been reported in the literature so far, namely a microwire fracture in the middle cerebral artery. This was successfully removed with an Eric stent-retriever. The potential causes and possible management strategies are discussed.
Eksperimentasi Kluwih (Artocarpus camansi) sebagai Warna Alam pada Tekstil
Authors: Sedjati Djandjang Purwo , Yantari Zahra Azkia Putri 
Published: May 2021

Berbagai macam tumbuhan dapat digunakan sebagai pewarna tekstil. Namun sejak ditemukannya zat warna sintetis pada abad 19, maka produksi tekstil di Indonesia beralih ke zat warna sintetis. Sayangnya dampak yang ditimbulkan dari limbah zat warna sintetis ini mencemari lingkungan hidup manusia. Pelarangan penggunaan pewarna sintetis di Eropa dan Amerika, serta isu global yaitu Back to Nature, merupakan hal yang tidak mungkin dihindari, bahkan harus dilaksanakan secara konsisten dan berkelanjutan. Produk tekstil juga berhadapan dengan tuntutan selera masyarakat masa kini, yaitu kebutuhan fashion dan interior, serta kebutuhan karya-karya yang dapat memberi kepuasan batin, sehingga diperlukan ciptaan karya baru yang kreatif dan inovatif. Dalam rangka mencari keberagaman dan pengkayaan warna dari tumbuhan yang ada di Indonesia, penulis ingin mengambil tumbuhan Kluwih (Artocarpus camansi) sebagai pewarna alam untuk tekstil dengan teknik celup dan cetak langsung (ecoprint). Metode pustaka, observasi dan eksperimentasi digunakan untuk mengumpulkan data. Metode practice based research digunakan untuk memperoleh pengetahuan baru melalui riset praktek dan hasil riset praktek. Metode eksperimen digunakan untuk mendapatkan ilmu pengetahuan baru terutama pada pewarna alam serta improvisasi jika dalam pelaksanaan menemukan ide-ide baru. Pada terapan warna ini akan dilakukan dengan teknik batik, celup dan ecoprint.
Análise da utilização de dessensibilizante no uso prévio ao clareamento dentário: revisão narrativa
Authors: Palma Flávio Augusto de Moraes , Abreu Gustavo Baruc Andrade , Silva Tamires Mirely Reis , Souza Victor Arthur Rodrigues de , Barbosa Ezequiel Santos , Freire Gabriel Santana , Neves Gabriel Santos , Souza Mariana Matos de , Martim Letícia , Nahsan Flavia Pardo Salata 
Published: May 2021

Objetivo: Analisar se existe eficácia na utilização de dessensibilizantes antes do tratamento clareador para a diminuição da sensibilidade dentária. Revisão bibliográfica: Para os pacientes que possuem dentes vitais escurecidos, o clareamento dentário é um dos procedimentos odontológicos mais solicitados pelos pacientes que querem um sorriso mais agradável. Diante do tratamento de clareamento dentário, é de extrema importância ter o conhecimento que devido a penetração do agente clareador nos túbulos dentinários, devido à perda de mineral dental, é onde pode ocorrer a sensibilidade dentinária. A sensibilidade dentinária ocorre devido à desobliteração dos túbulos dentinários, onde ocorre a comunicação do meio externo com o tecido dentinário. Uma das alternativas para controlar ou diminuir a sensibilidade dentária após ou durante um tratamento clareador é a utilização de dessensibilizantes, onde sua principal função dos agentes dessensibilizantes e obliterar os túbulos dentinários. Considerações finais: A técnica com comprovação de eficácia indicada por estudos clínicos controlados indica o uso de géis dessensibilizantes previamente ao clareamento em consultório.