bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decrease of choriocapillary vascular density measured by optical coherence tomography angiography in Vogt-Koyanagi-Harada disease
Authors: Liang Anyi , Jia Shanshan , Gao Fei , Han Xiaoxu , Pei Minghang , Qu Yi , Xiao Junyan , Zhao Chan , Zhang Meifen 
Published: July 2021

Abstract
Purpose
Changes of choroidal circulation throughout the disease course of Vogt-Koyanagi-Harada (VKH) disease and the clinical significance remain unclear. Choriocapillary vascular density (CC VD) measured by optical coherence tomography angiography (OCTA) were compared in different disease stages of VKH and its correlation with other parameters was analyzed, aiming to explore their clinical relevance.

Methods
This is a retrospective case series. One hundred and fourteen VKH patients and 47 normal controls (NCs) were included. Patients were grouped into the acute uveitic, convalescent, and chronic recurrent stages (only anterior recurrent cases included), and OCTA images were obtained from VKH patients in these stages. Best corrected visual acuity (BCVA), CC VD, and subfoveal choroidal thickness (SFCT) were recorded and compared.

Results
CC VD in acute (58.26% ± 0.84%), convalescent (64.85% ± 0.33%), and chronic recurrent (62.78% ± 0.70%) stage of VKH patients were all significantly lower than that in NCs (66.37% ± 0.41%) (p < 0.001, p = 0.017, and p < 0.001, respectively). CC VD increased by 6.59% ± 0.91% with resolution of acute inflammation (p < 0.001) and decreased by 2.07% ± 0.74% during anterior uveitis relapse (p = 0.009). Patients with a positive history of anterior recurrence had lower CC VD (− 2.43% ± 0.75%, p = 0.003) in the convalescent stage than those without. CC VD was negatively correlated with logMAR BCVA in VKH (r =  − 0.261, p < 0.001).

Conclusion
CC VD was decreased in every stage of VKH. CC VD has the potential to reflect the status of uveitis and might be promising in monitoring the disease activity. OCTA is a convenient and straightforward tool to evaluate choroidal vascularity, and CC VD provides supplemental quantitative information of the choriocapillaris. Further studies are needed to explore the values of OCTA quantitative parameters in monitoring VKH progression, predicting visual prognosis, and guiding clinical decisions.
The language profile in multiple system atrophy: an exploratory study
Authors: Cuoco Sofia , Picillo Marina , Carotenuto Immacolata , Erro Roberto , Catricalà Eleonora , Cappa Stefano , Pellecchia Maria Teresa , Barone Paolo 
Published: July 2021

Abstract
Background
The evidence about the language performance profile of multiple system atrophy (MSA) is limited, but its definition may lead to a more comprehensive characterization of the disorder and contribute to clarify the involvement of the basal ganglia in language abilities.

Objective
The objectives of the study were: (1) to evaluate the reliability of the Screening for Aphasia in NeuroDegeneration (SAND) in MSA patients; (2) compare the linguistic profiles among MSA and Parkinson’s disease (PD) patients and healthy controls (HC), and (3) assess relationships between language impairment and cognitive status and MSA motor subtypes.

Methods and results
Forty patients with a diagnosis of MSA, 22 HC and 17 patients with PD were enrolled in the present study. By excluding the writing task that showed a poor acceptability, we showed that the MSA-tailored SAND Global Score is an acceptable, consistent and reliable tool to screen language disturbances in MSA. MSA patients performed worse than HC, but not than PD, in MSA-tailored SAND Global Score, repetition, reading and semantic association tasks. We did not find significant differences between MSA phenotypes. MSA patients with mild cognitive impairment-multiple domain presented worse language performances as compared to MSA patients with normal cognition and mild cognitive impairment-single domain.

Conclusion
The MSA-tailored SAND Global Score is a consistent and reliable tool to screen language disturbances in MSA. Language disturbances characterize MSA patients irrespective of disease phenotype, and parallel the decline of global cognitive functions.
A systematic review on diagnostics and surgical treatment of adult right-sided Bochdalek hernias and presentation of the current management pathway
Authors: Ramspott J. P. , Jäger T. , Lechner M. , Schredl P. , Gabersek A. , Mayer F. , Emmanuel K. , Regenbogen S. 
Published: July 2021

Abstract
Purpose
Bochdalek hernia is a congenital diaphragmatic hernia. The incidence in adults is estimated around 0.17%. Right-sided hernias are much more seldom than left-sided ones because of faster closure of the right pleuroperitoneal canal and the protective effect of the liver. Due to its rarity, there have been no large prospective or retrospective studies following great need for evidence-based diagnostics and treatment strategies. In this systematic review, we evaluated the current evidence of diagnostics, treatment, and follow-up of adult right-sided Bochdalek hernias.

Methods
According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines a systematic literature review was conducted in PubMed and Cochrane library from 2004 to January 2021. The literature search included all studies with non-traumatic right-sided Bochdalek hernias. Literature on left- or both-sided, pregnancy-associated, pediatric, and other types of hernias were explicitly excluded. Quality assessment of the included studies was performed.

Results
Database search identified 401 records. After eligibility screening 41 studies describing 44 cases of right-sided non-traumatic Bochdalek hernias in adulthood were included for final analysis. Based upon the systematic literature review, the current diagnostic, therapeutic, and follow-up management pathway for this rare surgical emergency is presented.

Conclusion
This systematic review underlined that most studies investigating management of adult non-traumatic right-sided Bochdalek hernias are of moderate to low methodological quality. Hernias tend to occur more frequently in middle-aged and older women presenting with abdominal pain and dyspnea. A rapid and accurate diagnosis following surgical repair and regular follow-up is mandatory. High-quality studies focusing on the management of this rare entity are urgently needed.
Differences in social-space–time behaviour of two red deer herds (Cervus elaphus)
Authors: Gillich Benjamin , Michler Frank-Uwe , Stolter Caroline , Rieger Siegfried 
Published: July 2021

AbstractSocial-space–time-behaviour has developed very differently (e.g. a, loner, a herd, a pack) in the animal kingdom and depends on many different factors, like food availability, competition, predator avoidance or disturbances. It is known, that red deer are differently distributed in human disturbed areas compared to areas with less anthropogenic influences. But knowledge about the potential influence of human presence on social associations and interactions is rare, albeit differences may result in changing impacts on the environment, such as habitat utilization and feeding damage. Therefore, we investigated differences in the space use and social association of red deer. We studied two radio-collared herds of non-migratory populations in two study areas, which were comparable in landscape structure and vegetation structure, but differed in accessibility for visitors and the extent of their presence. Between the two study sites we compared the home range size, the differences in the extent of home range overlap within each study site and the space–time association (Jacobs Index) of individuals. Additionally, we present data on seasonal variations of home range sizes and social association all year round. In order to compare human activity in the study sites, we used the data from our long-term camera trap monitoring. The herd in the area with more human activity had significantly smaller home ranges and had greater year-round social associations in almost all seasons, except summer. We assume that smaller home ranges and higher association between animals may result in a higher feeding pressure on plants and a patchier utilization in areas with higher disturbances.
Considering sex/gender in interventions to promote children’s and adolescents’ leisure-time physical activity: a systematic review and meta-analysis
Authors: Schulze Carolin , Bucksch Jens , Demetriou Yolanda , Emmerling Sandra , Linder Stephanie , Reimers Anne K 
Published: July 2021

Abstract
Aim
The main objectives of this systematic review were to evaluate the effects of interventions on leisure-time PA of boys and girls and to appraise the extent to which studies have taken sex/gender into account.

Subject and methods
PRISMA guidelines were followed. Two researchers independently screened studies for eligibility and assessed the risk of bias. Descriptive analyses were conducted to evaluate intervention effects in relation to the consideration of sex/gender in the studies based on a newly developed checklist. Additionally, meta-analyses were performed to determine the effect of interventions on girls’ and boys’ leisure-time PA.

Results
Overall 31 unique studies reported 44 outcomes on leisure-time PA and 20,088 participants were included in the current study. Consideration of sex/gender aspects in studies is low. PA outcomes with statistically significant same/similar effects in boys and girls showed higher quality of reporting sex/gender aspects of theoretical and/or conceptual linkages with sex/gender, measurement instruments, intervention delivery, location and interventionists and participant flow than PA outcomes without significant effects in both boys and girls or effects only in boys or girls. Interventions had a small but significant effect on girls (number of included studies (k) = 9, g = 0.220, p = .003) and boys (k = 7, g = 0.193, p = .020) leisure-time PA.

Conclusion
Higher reporting of sex/gender aspects may improve leisure-time PA of boys and girls. Nevertheless, there remains a need to address sufficient consideration of sex/gender aspects in interventions in the context of PA.
Philosophy of Science and Philosophy: The Long Flight Home
Authors: Marcos Alfredo 
Published: July 2021

AbstractIn this article, I argue that there is philosophy of science since philosophy existed. Thus, the idea that the philosophy of science was born with neopositivism is historically wrong and detrimental to the development of the philosophy of science itself. Neopositivism tried to found the philosophy of science as an anti-philosophical discipline, as a field of study that came to replace simple philosophy. The attempt was maintained for thirty years, but failed. Now, this does not mean that we cannot make good philosophy of science today, but that the philosophy of science has returned to the common house of philosophy, it is gradually recovering the connection that it should never have lost with the main philosophical traditions and disciplines.
A new method for earthquake-induced damage identification in historic masonry towers combining OMA and IDA
Authors: Kita Alban , Cavalagli Nicola , Venanzi Ilaria , Ubertini Filippo 
Published: July 2021

AbstractThis paper presents a novel method for rapidly addressing the earthquake-induced damage identification task in historic masonry towers. The proposed method, termed DORI, combines operational modal analysis (OMA), FE modeling, rapid surrogate modeling (SM) and non-linear Incremental dynamic analysis (IDA). While OMA-based Structural Health Monitoring methods using statistical pattern recognition are known to allow the detection of small structural damages due to earthquakes, even far-field ones of moderate intensity, the combination of SM and IDA-based methods for damage localization and quantification is here proposed. The monumental bell tower of the Basilica of San Pietro located in Perugia, Italy, is considered for the validation of the method. While being continuously monitored since 2014, the bell tower experienced the main shocks of the 2016 Central Italy seismic sequence and the on-site vibration-based monitoring system detected changes in global dynamic behavior after the earthquakes. In the paper, experimental vibration data (continuous and seismic records), FE models and surrogate models of the structure are used for post-earthquake damage localization and quantification exploiting an ideal subdivision of the structure into meaningful macroelements. Results of linear and non-linear numerical modeling (SM and IDA, respectively) are successfully combined to this aim and the continuous exchange of information between the physical reality (monitoring data) and the virtual models (FE models and surrogate models) effectively enforces the Digital Twin paradigm. The earthquake-induced damage identified by both data-driven and model-based strategies is finally confirmed by in-situ visual inspections.
Investigating the drivers of the unprecedented Chernobyl Power Plant Wildfire in April 2020 and its effects on 137Cs dispersal
Authors: Newman-Thacker Fiona , Turnbull Laura 
Published: July 2021

AbstractIn this study, we explore the conditions that led to the unprecedented wildfire that occurred in the Chernobyl Exclusion Zone in April 2020 and the effect of this fire on 137Cs dispersal, as wildfires are important drivers of 137Cs resuspension, with potentially harmful consequences for the receiving ecosystems. We characterised the historical wildfire record between 2000 and 2020 using the MCD64A1.006 MODIS Burned Area Monthly Global 500 m dataset and assessed the climatic conditions associated with these wildfire events using ERA5-Land reanalysis data. We also examined fire danger indices at the time of these wildfires. We then explored the widespread effects of the April 2020 wildfire on 137Cs resuspension and subsequent deposition using the NOAA-HYSPLIT model, concluding that the impacts of such resuspension on areas further afield were minimal. Results show that climatic conditions leading to severe wildfires are increasing, especially during March and April. High soil moisture, relative humidity and extreme temperature anomalies are associated with the largest wildfires on record, and fire risk indices at the time of the April 2020 fire were higher than for other large fires on record. We have estimated that 3854 GBq of 137Cs resuspended during the CPPF, with atmospheric transport dominant over Russia, Ukraine, Moldova and Kazakhstan. The observed increase in large wildfires will have implications for wildfire-driven soil erosion processes, which will further exacerbate the effects of atmospheric-driven 137Cs redistribution.
Pharmacists’ involvement in COVID-19 vaccination across Europe: a situational analysis of current practice and policy
Authors: Paudyal Vibhu , Fialová Daniela , Henman Martin C. , Hazen Ankie , Okuyan Betul , Lutters Monika , Cadogan Cathal , da Costa Filipa Alves , Galfrascoli Elena , Pudritz Yvonne Marina , Rydant Silas , Acosta-Gómez Jaime 
Published: July 2021

AbstractOne year since the emergence of the COVID-19 pandemic, rapid response measures have been implemented internationally to mitigate the spread of the virus. Following rapid and successful pre-clinical and human trials, several vaccines have been authorised for use across Europe through
the European Medicines Agency and national regulatory authorities. Clinical trials have shown promising results including important reductions in disease severity, hospitalisation and mortality. In order to maximise the public health benefit of available vaccines, there is a pressing need to vaccinate a large proportion of the population. Internationally, this has prompted coordination of existing services at enormous scale, and development and implementation of novel vaccination strategies to ensure maximum inoculation over the shortest possible timeframe. Pharmacists are being promoted as healthcare professionals that enhance roll-out of COVID-19 vaccination programmes. This paper aims to summarise current policy and practice in relation to pharmacists’ involvement in COVID-19 vaccination in 13 countries across Europe.
Clinical pharmacists in Dutch general practice: an integrated care model to provide optimal pharmaceutical care
Authors: Hazen Ankie , Sloeserwij Vivianne , Pouls Bart , Leendertse Anne , de Gier Han , Bouvy Marcel , de Wit Niek , Zwart Dorien 
Published: July 2021

AbstractBackground Medication-related harm is a major problem in healthcare. New models of integrated care are required to guarantee safe and efficient use of medication. Aim To prevent medication-related harm by integrating a clinical pharmacist in the general practice team. This best practice paper provides an overview of 1. the development of this function and the integration process and 2. its impact, measured with quantitative and qualitative analyses. Setting Ten general practices in the Netherlands. Development and implementation of the (pragmatic) experiment We designed a 15-month workplace-based post-graduate learning program to train pharmacists to become clinical pharmacists integrated in general practice teams. In close collaboration with general practitioners, clinical pharmacists conduct clinical medication reviews (CMRs), hold patient consultations for medication-related problems, carry out quality improvement projects and educate the practice staff. As part of the Pharmacotherapy Optimisation through Integration of a Non-dispensing pharmacist in a primary care Team (POINT) intervention study, ten pharmacists worked full-time in general practices for 15 months and concurrently participated in the training program. Evaluation of this integrated care model included both quantitative and qualitative analyses of the training program, professional identity formation and effectiveness on medication safety. Evaluation The integrated care model improved medication safety: less medication-related hospitalisations occurred compared to usual care (rate ratio 0.68 (95% CI: 0.57–0.82)). Essential hereto were the workplace-based training program and full integration in the GP practices: this supported the development of a new professional identity as clinical pharmacist. This new caregiver proved to align well with the general practitioner. Conclusion A clinical pharmacist in general practice proves a feasible integrated care model to improve the quality of drug therapy.
Functional Inequalities for Two-Level Concentration
Authors: Barthe Franck , Strzelecki Michał 
Published: July 2021

AbstractProbability measures satisfying a Poincaré inequality are known to enjoy a dimension-free concentration inequality with exponential rate. A celebrated result of Bobkov and Ledoux shows that a Poincaré inequality automatically implies a modified logarithmic Sobolev inequality. As a consequence the Poincaré inequality ensures a stronger dimension-free concentration property, known as two-level concentration. We show that a similar phenomenon occurs for the Latała–Oleszkiewicz inequalities, which were devised to uncover dimension-free concentration with rate between exponential and Gaussian. Motivated by the search for counterexamples to related questions, we also develop analytic techniques to study functional inequalities for probability measures on the line with wild potentials.
Does retirement reduce familiarity with Information and Communication Technology?
Authors: Cavapozzi Danilo , Dal Bianco Chiara 
Published: July 2021

AbstractThis paper analyses the effect of retirement on the familiarity with Information and Communication Technology (ICT) of older individuals. We argue that inability to cope with ICT might represent a threat for older individuals’ social inclusion. To account for the potential endogeneity of retirement with respect to familiarity with ICT, we instrument retirement decision with the age-eligibility for early and statutory retirement pension schemes. Using data from the Survey of Health, Ageing and Retirement in Europe, we show that retirement reduces the computer literacy and the frequency of internet utilization for men and women. This finding is robust to the inclusion as control factors of health, cognition and social network indicators, which the literature has shown to be affected by retirement. Overall, the reduction in the familiarity with ICT after retirement tends to be stronger in the long-run.
Geographic modeling and simulation systems for geographic research in the new era: Some thoughts on their development and construction
Authors: Chen Min , Lv Guonian , Zhou Chenghu , Lin Hui , Ma Zaiyang , Yue Songshan , Wen Yongning , Zhang Fengyuan , Wang Jin , Zhu Zhiyi , Xu Kai , He Yuanqing 
Published: July 2021

AbstractRegionality, comprehensiveness, and complexity are regarded as the basic characteristics of geography. The exploration of their core connotations is an essential way to achieve breakthroughs in geography in the new era. This paper focuses on the important method in geographic research: Geographic modeling and simulation. First, we clarify the research requirements of the said three characteristics of geography and its potential to address geo-problems in the new era. Then, the supporting capabilities of the existing geographic modeling and simulation systems for geographic research are summarized from three perspectives: Model resources, modeling processes, and operational architecture. Finally, we discern avenues for future research of geographic modeling and simulation systems for the study of regional, comprehensive and complex characteristics of geography. Based on these analyses, we propose implementation architecture of geographic modeling and simulation systems and discuss the module composition and functional realization, which could provide theoretical and technical support for geographic modeling and simulation systems to better serve the development of geography in the new era.
Influence of Simulated Deep Brain Stimulation on the Expression of Inflammatory Mediators by Human Central Nervous System Cells In Vitro
Authors: Kubelt Carolin , Molkewehrum Henri , Lucius Ralph , Synowitz Michael , Held-Feindt Janka , Helmers Ann-Kristin 
Published: July 2021

AbstractDeep brain stimulation (DBS) seems to modulate inflammatory processes. Whether this modulation leads to an induction or suppression of inflammatory mediators is still controversially discussed. Most studies of the influence of electrical stimulation on inflammation were conducted in rodent models with direct current stimulation and/or long impulses, both of which differ from the pattern in DBS. This makes comparisons with the clinical condition difficult. We established an in-vitro model that simulated clinical stimulation patterns to investigate the influence of electrical stimulation on proliferation and survival of human astroglial cells, microglia, and differentiated neurons. We also examined its influence on the expression of the inflammatory mediators C-X-C motif chemokine (CXCL)12, CXCL16, CC-chemokin-ligand-2 (CCL)2, CCL20, and interleukin (IL)-1β and IL-6 by these cells using quantitative polymerase chain reaction. In addition, protein expression was assessed by immunofluorescence double staining. In our model, electrical stimulation did not affect proliferation or survival of the examined cell lines. There was a significant upregulation of CXCL12 in the astrocyte cell line SVGA, and of IL-1β in differentiated SH-SY5Y neuronal cells at both messenger RNA and protein levels. Our model allowed a valid examination of chemokines and cytokines associated with inflammation in human brain cells. With it, we detected the induction of inflammatory mediators by electrical stimulation in astrocytes and neurons.