bluuebunny/crossref_metadata_2025_split huggingface dataset:
ALTERAÇÕES GENÉTICAS E SUAS IMPLICAÇÕES NA RESISTÊNCIA À ANESTESIA E NA ESCOLHA DA TÉCNICA ANESTÉSICA: ANÁLISE DOS ASPECTOS CLÍNICOS
Authors: Mendes Talita Ponte , De Sousa Maria Natália Feitosa , Castro Alves Neto Franklin de , Maia Ivana Cristina Vieira de Lima , Reis Nely Marjollie Guanabara Teixeira 
Published: July 2021

A escolha do tipo de anestésico a ser utilizado em pacientes com variações genéticas requer um estudo detalhado das alterações genéticas e monitoramento constante do paciente. Desse modo, buscou-se analisar as implicações que alterações genéticas representam na resistência a anestésicos e na escolha da técnica anestésica. Foi realizada revisão narrativa em maio de 2019 nas bases de dados Literatura Latino-americana e do Caribe Ciências da Saúde (LILACS), Medline, Scopus, Cochrane Library e Web of Science. Foram selecionados 12 artigos com os seguintes descritores: genética, anestesia local; monitoramento; canais de sódio; monitoração neuromuscular. A literatura sobre a genética da resistência à anestesia versa sobre aspectos genéticos e clínicos das doenças relacionadas, demonstrando a evolução do conhecimento da genética e da anestesia, além de destacar as técnicas usadas nesses casos. As evidências encontradas descreveram informações genéticas e clínicas das doenças, com ênfase nas implicações dos efeitos colaterais tardios, precoces ou inesperados relacionados à indução anestésica.
MECANISMO DE AÇÃO E REAÇÕES ADVERSAS DOS ANTIVIRAIS PRECONIZADOS PARA HEPATITE C NO BRASIL
Authors: Araújo Júnior José Raul Rocha de , Silva Ariane Araújo de Carvalho da , Souza Simone Cristina Silva de 
Published: July 2021

A hepatite C é uma doença que afeta toda população mundial, afetando também a qualidade de vida da população. O uso de medicamentos é fundamental para o processo terapêutico dos pacientes com hepatite C. O tratamento da hepatite C enfrentou diversos obstáculos com a diversidade pangenotípica viral e as reações adversas do tratamento enfrentadas pelos infectados com o vírus. Entretanto, com o decorrer dos anos, a evolução do mercado farmacêutico e dos medicamentos antivirais ocorreu em diversos campos da pesquisa contra a hepatite C. Neste contexto se torna importante compreender os mecanismos de ação e reações adversas dos fármacos utilizados para o tratamento da hepatite C no Brasil. A pesquisa trata de uma revisão bibliográfica, por meio de levantamento de artigos científicos nas bases de dados LILACs, Pubmed, Google Acadêmico e SciELO, portarias e boletins do Ministério da Saúde. Melhorias moleculares dos fármacos visam diminuir o tempo de tratamento, aumentando assim a adesão do paciente, pelo fato desses novos medicamentos apresentarem efeitos adversos mais leves. A tendência da indústria farmacêutica, no que diz respeito ao tratamento da hepatite C, é produzir medicamentos pangenotípicos, ou seja, que atuam em todos os genótipos do VHC.
BILANGAN TERHUBUNG PELANGI PADA GRAF SALJU (Sn_m)
Authors: Noor Cindy Aisa Putri , Yahya Lailany , Nasib Salmun K , Yahya Nisky Imansyah 
Published: July 2021

Suatu graf dikatakan terhubung pelangi jika terdapat lintasan antara dua titik yang setiap sisi-sisinya memiliki warna berbeda. Misalkan terdapat suatu graf G tak trivial dengan definisi warna c:E(G)->{1,2,3,...}, maka bilangan terhubung pelangi dari graf G yaitu minimum k dari pewarnaan-k pelangi yang digunakan untuk mewarnai graf G dan dinotasikan dengan rc(G). Tujuan dari penelitian ini yaitu untuk menentukan bilangan terhubung pelangi pada graf salju (Sn_m). Metode yang digunakan pada penelitian ini yaitu metode studi literatur dengan prosedur sebagai berikut; menggambar graf salju, mencari pola bilangan terhubung pelangi, dan membuktikan teorema bilangan terhubung pelangi pada graf salju (Sn_m). Sehingga diperoleh rc(Sn_m)=m+1 untuk 3<=m<=7 dan m={9,10} dan rc(Sn_m)=m untuk m=8 dan m>=11.
Maternal and neonatal outcomes in women with disorders of lipid metabolism
Authors: Cai Emmy , Czuzoj-Shulman Nicholas , Malhamé Isabelle , Abenhaim Haim A. 
Published: July 2021

Abstract

Objectives
The effects of lipid metabolism disorders (LMD) on pregnancy outcomes is not well known. The purpose of this study is to evaluate the impact of LMD on maternal and fetal outcomes.

Methods
Using the Healthcare Cost and Utilization Project – National Inpatient Sample from the United States, we carried out a retrospective cohort study of all births between 1999 and 2015 to determine the risks of complications in pregnant women known to have LMDs. All pregnant patients diagnosed with LMDs between 1999 and 2015 were identified using the International Classification of Disease-9 coding, which included all patients with pure hypercholesterolemia, pure hyperglyceridemia, mixed hyperlipidemia, hyperchylomicronemia, and other lipid metabolism disorders. Adjusted effects of LMDs on maternal and newborn outcomes were estimated using unconditional logistic regression analysis.

Results
A total of 13,792,544 births were included, 9,666 of which had an underlying diagnosis of LMDs for an overall prevalence of 7.0 per 10,000 births. Women with LMDs were more likely to have pregnancies complicated by diabetes, hypertension, and premature births, and to experience myocardial infarctions, venous thromboembolisms, postpartum hemorrhage, and maternal death. Their infants were at increased risk of congenital anomalies, fetal growth restriction, and fetal demise.

Conclusions
Women with LMDs are at significantly higher risk of adverse maternal and newborn outcomes. Prenatal counselling should take into consideration these risks and antenatal care in specialized centres should be considered.
The germanides APtGe2 (A = Ca, Sr, Eu)
Authors: Klenner Steffen , Reimann Maximilian Kai , Pöttgen Rainer 
Published: July 2021

Abstract
The germanides APtGe2 (A = Ca, Sr, Eu) were synthesized from the elements in sealed tantalum ampoules in an induction furnace followed by annealing. The polycrystalline samples were characterized by powder X-ray diffraction (Guinier patterns). The structures of CaPtGe2 (CeRhSn2 type, Cmcm, a = 443.45(3), b = 1593.03(12), c = 886.15(6) pm, wR = 0.0464, 673 F
2 values, 30 variables) and EuPt1.043(5)Ge1.957(5) (CeNiSi2 type, Cmcm, a = 445.23(4), b = 1752.5(2), c = 429.63(4) pm, wR = 0.0415, 389 F
2 values, 19 variables) were refined from single crystal X-ray diffractometer data. One of the germanium site in EuPt1.043(5)Ge1.957(5) showed a small Ge/Pt mixed occupancy. SrPtGe2 (a = 451.13(6), b = 1764.8(2), c = 429.60(5) pm) is isotypic with EuPtGe2. The platinum atoms in both germanides have trigonal prismatic coordination: Pt@Ca4Ge2 and Pt@Eu4Ge2. The germanium substructures differ significantly: Ge2 dumb-bells with 246 and 262 pm Ge–Ge distances in CaPtGe2
versus germanium zig-zag chains (253 pm Ge–Ge distances) and a distorted square net (309 pm Ge–Ge distances) in EuPtGe2. CaPtGe2 and SrPtGe2 are diamagnetic. EuPtGe2 is a Curie–Weiss paramagnet with an experimental magnetic moment of 7.88(1) µB Eu atom−1. The purely divalent character of europium is manifested by a single signal at δ = −11.38(1) mm s−1 in the 151Eu Mössbauer spectrum at 78 K. EuPtGe2 orders antiferromagnetically at T
N = 5.4(1) K.
Carbimazole induced rhabdomyolysis
Authors: O’Donnell Niamh , McCarthy Aisling , Thong Ken 
Published: July 2021

Summary
Carbimazole is a commonly used antithyroid drug (ATD), which is associated with several well-established side effects. However, Carbimazole-induced rhabdomyolysis is rarely reported in the literature. We report a 27-year-old male who presented with upper limb myalgia and significantly raised creatine kinase elevation, 1-month post commencement of Carbimazole for Graves’ disease. Carbimazole was ceased with subsequent clinical and biochemical improvement. Though the pathophysiology remains unclear, we hope to raise awareness regarding this rare adverse effect with a view to promote early recognition and prompt discontinuation of the offending medication caused by a commonly used medication in endocrinology.

Learning points

Musculoskeletal complaints can relate to unidentified and untreated hyperthyroidism. However one must be mindful that the treatment for these disorders can too induce myopathies.

ATD-induced myopathy should be considered when there is a temporal relationship between introduction of ATDs and the onset of symptoms.

If ATD-induced myopathy is being considered, other causes of myopathy should still be outruled.

Prompt discontinuation of potentially offending medications may provide resolution of symptoms and avoid significant consequences.
Skin in the game – Erroneous beliefs and emotional involvement as correlates of athletes' sports betting behavior and problems
Authors: Jones Christopher M. , Noël Benjamin 
Published: July 2021

Abstract

Background and aims
The sports betting market has been growing rapidly over the last years, as have reports of problematic gambling behavior associated with betting. Due to the well-documented gambling problems of famous athletes and the betting supportive nature of many sports-related environments, athletes have been highlighted as a potential group at-risk for problematic sports betting. However, there currently remains a lack of research on individual-level athlete-specific risk-factors or mechanisms that might contribute to the development and perpetuation of betting-related problems. Here, we examine the influence of two potential risk-factors on sports betting behavior and problems: erroneous beliefs and athletes' emotional involvement.

Methods
201 athletes with different levels of expertise completed a newly developed scale to assess both factors. Participants were sampled from the general German population, predominantly male (83.08%) and on average 29.52 (SD = 11.05) years old. We use principal components analysis to detect patterns of covariation, potentially due to the proposed underlying latent factors, and regression analyses to test associations of these factors with betting behavior and problems.

Results
We find that athletes' emotional involvement was strongly associated with betting problems whereas erroneous beliefs were not. However, distorted cognitions/beliefs were associated with higher volumes and more frequent betting activities.

Discussion and Conclusions
This might contribute to betting problems in the long run. These results highlight athletes' emotional involvement and erroneous beliefs as potential targets for future intervention and prevention efforts.
Humanized Care from the Perception of Oncology Patients from Southern Chile
Authors: Navarrete-Correa Tannia , Fonseca-Salamanca Flery , Barría R. Mauricio 
Published: July 2021

Objective. This work sought to determine the perception of behaviors of humanized nursing care and its relation with sociodemographic and clinical variables in patients hospitalized in a Hemato-Oncology Department.
Methods. Analytic cross-sectional study conducted with 51 patients hospitalized in the Hemato-Oncology Unit at Hospital Base Valdivia, Chile. A survey containing sociodemographic and clinical information was applied together with the questionnaire on Perception of Behaviors of Humanized Nursing Care 3rd version” -PBHNC 3v (32 items distributed in the categories: Qualities of nursing work, Openness to nurse-patient communication, and Willingness to care).
Results. Of the participants, 51% were women, with mean age of 46.5±16.6 years; 54.9% were diagnosed with Lymphoma and 78.4% were in the treatment induction stage. In 30 of the 32 items of the instrument, > 90% of the participants evaluated compliance with the behavior of caring at level of “always”. By categories, it was observed that for “Willingness to care” there was significantly lower score among patients from 18 to 49 years of age (p=0.0455). For the category “Openness to nurse-patient communication” lower median score existed in patients with Myeloma (p=0.0043) and in patients in the Remission-Consolidation stage (p=0.0084). Days of hospitalization were associated significantly with the category “Willingness to care”, being lower with 16 days and more (p=0.0242).
Conclusion. High frequency was observed of humanized-care behaviors and small differences in their assessment that were associated with demographic factors like age, and clinical factors, like diagnosis, treatment stage, and days of hospitalization.
Effect of Educational Interventions to Reduce Readmissions due to Heart Failure Decompensation in Adults: a Systematic Review and Meta-analysis
Authors: Cañon-Montañez Wilson , Duque-Cartagena Tatiana , Rodríguez-Acelas Alba Luz 
Published: July 2021

Objective. To estimate the combined effect of educational interventions (EI) on decreased readmissions and time of hospital stay in adults with heart failure, compared with usual care.
Methods. Systematic review (SR) and meta-analysis (MA) of randomized controlled trials that followed the recommendations of the PRISMA statement. The protocol was registered on PROSPERO (CRD42019139321). Searches were made from inception until July 2019 in the databases of PubMed/Medline, Embase, Cochrane CENTRAL, Lilacs, Web of Science, and Scopus. The MA was conducted through the random effects model. The effect measure used for the dichotomous outcomes was relative risk (RR) and for continuous outcomes the mean difference (MD) was used, with 95% confidence intervals (CI). Heterogeneity was evaluated through the inconsistency statistic (I2).
Results. Of 2369 studies identified, 45 were included in the SR and 43 in the MA. The MA of studies with follow-up at six months showed a decrease in readmissions of 30% (RR: 0.70; 95% CI: 0.58 to 0.84; I2: 0%) and the 12-month follow-up evidenced a reduction of 33% (RR: 0.67; 95% CI: 0.58 to 0.76; I2: 52%); both analyses in favor of the EI group. Regarding the time of hospital stay, a reduction was found of approximately two days in patients who received the EI (MD: -1.98; 95% CI: -3.27 to -0.69; I2: 7%).
Conclusion. The findings support the benefits of EI to reduce readmissions and days of hospital stay in adult patients with heart failure.
Father's participation in prenatal care and childbirth: contributions of nurses' interventions
Authors: Lima Katherine Souza Vidal , Carvalho Monalysa Meireles de Barros , Lima Tainara Morais Cerqueira , Alencar Delmo de Carvalho , De Sousa Anderson Reis , Pereira Álvaro 
Published: July 2021

Objective. To describe the discourse of men about participation in prenatal care and childbirth/birth of their children from the contributions made by nurses.
Methods. This is an exploratory study, with a qualitative approach, carried out in the wards of a public hospital/maternity hospital in a city in the Northeast, Brazil. Fifty men participated in the study. Data collection with an individual interview, guided by semi-structured script. The data were recorded, transcribed in full, systematized, categorized, and organized by the Collective Subject Discourse method analyzed under the framework of Gender and Masculinities.
Result. It was evident in the collective discourse of men that how fatherhood is understood is in transformation, and that the father's participation in the pregnancy and parturition context is under construction. The study showed the change in behavior of men, as well as the expression of new models of masculinities, about the exercise of assisted parenthood motivated by nurses.
Conclusion. Nurses' contributions represented necessary elements for greater adherence and male involvement and revealed a possibility to re-signify male identity from the reconstruction of the idea of fatherhood, in the context of pregnancy and parturition.
Preliminary report on the use of digital strong motion recorders in the Mexicali Valley, Baja California
Authors: Anderson John G. , Brune James N. , Prince Jorge , Vernon Frank L. 
Published: July 2021

AbstractA network of 12 digital strong motion accelerographs has been operating in the Mexicali Valley, Baja California, Mexico, since 1978. The instruments have triggered reliably, except for external problems, such as power failures and site harassment. Data from two important earthquakes and several smaller shocks have been recovered. These data have a noise level which appears to be no worse than that on digitized records from analog strong motion accelerographs, in spite of design errors which resulted in increased instrumental noise levels in several of the accelerographs (these design errors have recently been corrected). Digital recording of strong motion promises great advantages over analog recording through recovery of the initial motions, greater dynamic range, rapid playback, and lower equivalent instrumental noise level because manual or semiautomatic digitization of an analog record is not required.
Retrieval of source-extent parameters and the interpretation of corner frequency
Authors: Silver Paul 
Published: July 2021

AbstractA method is proposed for retrieving source-extent parameters from far-field body-wave data. At low frequency, the normalized P- or S-wave displacement amplitude spectrum can be approximated by |Ω^(r^,ω)| = 1 − τ2(r^)ω2/2 where r^ specifies a point on the focal sphere. For planar dislocation sources, τ2(r^) is linearly related to statistical measures of source dimension, source duration, and directivity. τ2(r^) can be measured as the curvature of |Ω^(r^,ω)| at ω = 0 or the variance of the pulse Ω^(r^,t). The quantity ωc=2τ−1(r^) is contrasted with the traditional corner frequency ω0, defined as the frequency at the intersection of the low- and high-frequency trends of |Ω^(r^,ω)|. For dislocation models without directivity, ωc(P) ≧ ωc(S) for any r^. A mean corner frequency defined by averaging τ2(r^) over the focal sphere, ω¯c=2&lt;τ2(r^)&gt;−1/2, satisfies ωc(P) &gt; ωc(S) for any dislocation source. This behavior is not shared by ω0. It is shown that ω0 is most sensitive to critical times in the rupture history of the source, whereas ωc is determined by the basic parameters of source extent. Evidence is presented that ωc is the corner frequency measured on actual seismograms. Thus, the commonly observed corner frequency shift (P-wave corner greater than the S-wave corner), now viewed as a shift in ωc is simply a result of spatial finiteness and is expected to be a property of any dislocation source. As a result, the shift cannot be used as a criterion for rejecting particular dislocation models.
Seismicity of the Garlock fault, California
Authors: Astiz Luciana , Allen Clarence R. 
Published: July 2021

AbstractThe Garlock fault is a 265-km-long left-slip fault striking northeastward from the San Andreas fault in southern California. Relocations of earthquakes that occurred from 1932 to 1981 on and near this major fault were made using the master-event technique. The spatial distribution of seismicity along the fault is different west and east of its midpoint near Rand, where the largest en-echelon offset and a marked change in strike occur. These two segments also display distinct geologic features and different seismic and aseismic behavior. The 150-km-long segment west of Rand has shown continuous low seismic activity during the past 50 yr, well-documented aseismic creep, and has a relatively complex fault trace. In contrast, the 155-km-long segment east of Rand has very few small earthquakes, no demonstrable creep, and a simpler fault trace. P-wave first-motion studies substantiate predominantly left-slip motion along the Garlock fault. Overall energy release during this 50-yr period gives a seismic moment rate of 2.75 × 1021 dyne-cm/yr, much lower than that inferred from Holocene geologic offsets, thus indicating that the Garlock fault currently represents a temporal seismic gap, and that the potential exists for large earthquakes. If behavior of the Garlock fault is similar to that of the San Andreas, the western segment of the fault can be compared with the central creeping segment of the San Andreas, and the eastern segment with those segments broken by the 1857 and 1906 earthquakes; thus larger events might be expected on the eastern segment than on the western segment, or, if the entire fault breaks during a single event, larger displacements toward the east.
Effect of structure geometry on strong ground motions: The Duwamish River Valley, Seattle, Washington
Authors: Langston Charles A. , Lee Jia-Ju 
Published: July 2021

AbstractA three-dimensional ray tracing algorithm is used to compute the high frequency response of an SH plane wave incident under several models of the sediment filled with Duwamish River Valley of central Seattle. Models are based on valley geometry previously determined using borehole logs. The SH-wave response is considered in an effort to simulate the S-wave radiation from the 1965 magnitude 6.5 Puget Sound earthquake. Although the structure models considered are two-dimensional, three-dimensional ray tracing is needed to treat incident SH waves of various incidence angles and azimuths of approach appropriate for the USCGS and ISC hypocenters of the 1965 event. Generally, amplification of the direct SH wave due to the curved basin geometry is comparable to an equivalent elastic layer over a half-space model. However, for points near the center of the valley, multiple S rays become focused after undergoing several reflections from the curved lower boundary of the valley fill. This produces an order of magnitude increase in effective amplification. A detailed study of these rays shows that significant amplitudes occur over narrow distance ranges (∼200 m) at the surface and that they are sensitive to moderate changes in incident wave direction. Focusing effects of this type were probably an important factor in damage caused by the 1965 earthquake, especially over the thicker portions of the Duwamish River Valley. Effects of “randomly” focused rays also give an explanation for the apparently capricious nature of strong ground shaking in the Puget Sound area.
S
*
Authors: Gutowski P. R. , Hron F. , Wagner D. E. , Treitel S. 
Published: July 2021

Abstract
The interesting and common situation of shallow point sources close to the free surface can be modeled using an explicit elastic finite difference procedure. If the source depth is less than the predominant wavelength from the surface or other well-defined elastic boundary, then shear waves S*, are generated with an amplitude which depends strongly on the source depth. As the source depth is decreased, the amplitude of the resulting shear wave increases exponentially and the particle motion is confined to a plane perpendicular to the direction of propagation. These shear waves radiate from a point on the boundary directly above the source with a radiation pattern that is zero at grazing incidence, rises to a positive maximum at about 55° from the vertical, changes polarity, and increases negatively until merging with the PS wave. Since the use of shallow explosive sources for seismic exploration is favorable for the generation of S*, we present a field data case as an illustration.
Seismicity and faulting in the Charlevoix zone of the St. Lawrence Valley
Authors: Anglin F. M. 
Published: July 2021

Abstract
Continuous monitoring of the seismically active Charlevoix zone since late 1977 has delineated the boundaries of the earthquake zone under the north shore and has enabled an association to be made with surface mapped faults that strike along the St. Lawrence Valley and dip to the southeast. Within the active zone, aseismic volumes are found under parts of the St. Lawrence River and another elongated zone of activity is found to the southeast on unmapped faults dipping under the river. The previous suggestions that the activity is related to old rift faults, which have been later weakened by a meteor impact, would seem to be upheld.