bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formation of Amphibole‐Bearing Peridotite and Amphibole‐Bearing Pyroxenite Through Hydrous Melt‐Peridotite Reaction and In Situ Crystallization: An Experimental Study
Authors: Wang Chunguang , Liang Yan , Xu Wenliang 
Published: January 2021

AbstractAmphibole is a common hydrous mineral in mantle rocks. To better understand processes leading to the formation of amphibole‐bearing peridotites and pyroxenites in the lithospheric mantle, we conducted experiments by juxtaposing a lherzolite against hydrous basaltic melts in Au‐Pd capsules. Two melts were examined, a basaltic andesite and a basalt, each containing 4 wt% of water. The experiments were run at 1200°C and 1 GPa for 3 or 12 h, and then cooled to 880°C and 0.8 GPa over 49 h. The reaction at 1200°C produced a melt‐bearing orthopyroxenite‐dunite sequence. Crystallization of the partially reacted melts during cooling lead to the formation of an amphibole‐bearing gabbronorite‐orthopyroxenite‐peridotite sequence. Orthopyroxene in the peridotite and orthopyroxenite has a poikilitic texture enclosing olivines and spinels. Amphibole in the peridotite occurs interstitial to olivine, orthopyroxene, clinopyroxene, and spinel. Comparisons of texture and mineral compositions in the experimental products with those from field observations allow a better understanding of hydrous melt‐rock reaction in the lithospheric mantle. Amphibole‐bearing pyroxenite veins (or dikes) can be formed in the lithospheric mantle or at the crust‐mantle boundary by interaction between hydrous melt and peridotite and subsequent crystallization. Hornblendite or amphibole gabbronorite can be formed in the veins when the flux of hydrous melt is high. Differences in reacting melt and peridotite compositions are responsible for the variation in amphibole composition in mantle xenoliths from different tectonic settings. The extent of melt‐rock reaction is a factor that control amphibole composition across the amphibole‐bearing vein and the host peridotite.
Remote Control of Filchner‐Ronne Ice Shelf Melt Rates by the Antarctic Slope Current
Authors: Bull Christopher Y. S. , Jenkins Adrian , Jourdain Nicolas C. , Vaňková Irena , Holland Paul R. , Mathiot Pierre , Hausmann Ute , Sallée Jean‐Baptiste 
Published: January 2021

AbstractRecent work on the Filchner‐Ronne Ice Shelf (FRIS) system has shown that a redirection of the coastal current in the southeastern Weddell Sea could lead to a regime change in which an intrusion of warm Modified Circumpolar Deep Water results in large increases in the basal melt rate. Work to date has mostly focused on how increases in the Modified Circumpolar Deep Water crossing the continental shelf break leads directly to heat driven changes in melting in the ice‐shelf cavity. In this study, we introduce a Weddell Sea regional ocean model configuration with static ice shelves. We evaluate a reference simulation against radar observations of melting, and find good agreement between the simulated and observed mean melt rates. We analyze 28 sensitivity experiments that simulate the influence of changes in remote water properties of the Antarctic Slope Current on basal melting in the FRIS. We find that remote changes in salinity quasi‐linearly modulate the mean FRIS net melt rate. Changes in remote temperature quadratically vary the FRIS net melt rate. In both salinity and temperature perturbations, the response is rapid and transient, with a recovery time‐scale of 5–15 years dependent on the size/type of perturbation. We show that the two types of perturbations lead to different changes on the continental shelf, and that ultimately different factors modulate the melt rates in the FRIS cavity. We discuss how these results, are relevant for ocean hindcast simulations, sea level, and melt rate projections of the FRIS.
Volume Transport Variability on the Northern Argentine Continental Shelf From In Situ and Satellite Altimetry Data
Authors: Lago L. S. , Saraceno M. , Piola A. R. , Ruiz‐Etcheverry L. A. 
Published: January 2021

AbstractDirect current observations and satellite altimetry data over the northern portion of the Argentine continental shelf are used to produce an 11‐month long hourly time series and a 25‐year long daily time series of along‐shore volume transport, respectively. At time scales longer than 20 days, the temporal variability of the in situ transport is significantly correlated with the transport inferred from satellite altimetry (r = 0.74). The mean in situ along‐shore transport is 2.65 ± 0.07 Sv (1 Sv = 106 m3 s−1) to the northeast and presents large variability, with a peak‐to‐peak range of 16 Sv. The extended satellite transport presents variability at multiple time scales. The annual cycle is the dominant signal, with a maximum during the austral autumn and a minimum during the austral spring. The interannual component of the transport is significantly correlated (r = −0.5) with the Southern Annular Mode (SAM). SAM‐induced along‐shore wind stress anomalies over the region modulate the cross‐shore pressure gradient that, in turn, modulates the along‐shore transport variability. This mechanism holds also at synoptic scales, highlighting the dominant role of the wind on the along‐shore transport. Satellite altimetry measurements also indicate that the cross‐shore pressure gradient generated by the variability of the Malvinas Current affects the along‐shore transport only in the outer 30 km of the continental shelf.
Impact of Different Nesting Methods on the Simulation of a Severe Convective Event Over South Korea Using the Weather Research and Forecasting Model
Authors: Madhulatha A. , Choi Suk‐Jin , Han Ji‐Young , Hong Song‐You 
Published: January 2021

AbstractIn this study, the effects of different nesting methods on simulating a flash‐flood‐producing severe convective event over Cheongju, South Korea on July 16, 2017 was examined. This event developed as part of a mesoscale convective system (MCS) accompanied by frontal forcing. Numerical experiments were conducted using the Weather Research and Forecasting model (WRF) employing one‐way concurrent (OWC), one‐way sequential (OWS), and two‐way (TW) nesting approaches with advanced physics options from Korean Integrated Model (KIM). Analysis of model simulations against Tropical Rainfall Measuring Mission (TRMM) and Automatic Weather Station (AWS) observations suggests that the TW nesting method performs better than both OW nesting methods in simulating rainfall. Large‐scale features, moisture, instability in the boundary layer, and the vertical distribution of meteorological parameters favorable for convection are better represented by TW nesting. Probability distribution Function (PDF) analysis from AWS/WRF reveals that the local‐scale distribution of surface meteorological parameters which affect storm intensity were well captured using TW. Further assessment of Equitable Threat score (ETS) also showed better precipitation forecast skill over different thresholds in TW. Vertical velocity in the innermost domain simulated using TW nesting is more consistent with ERA5 reanalysis. An additional MCS (11–13 July 2006) simulated using a similar numerical setup also benefited from TW nesting, increasing confidence in the initial findings. Along with frequent lateral boundary conditions, TW nesting allows multi‐scale interactions between parent and nested domains and improves the representation of both synoptic and local‐scale features, enhanced cloud hydrometeor, vertical velocity distributions, and subsequent rainfall.
Simulated Dust Transport in the Convective Boundary Layer
Authors: Cornwell Gavin C. , Xiao Heng , Berg Larry K. , Burrows Susannah M. 
Published: January 2021

AbstractSoil dusts are an important source of aerosol in agricultural regions and can affect the Earth's radiation budget through the modification of cloud properties, and in particular, through their ability to act as ice nucleating particles. In order to impact cloud properties, agricultural soil dusts need to be transported from the point of emission to cloud‐relevant altitudes. Vertical transport within the planetary boundary layer is strongly controlled by turbulence and is challenging to represent accurately in regional and global models. Large‐eddy simulations (LES) are run at resolutions capable of resolving most of the turbulent energy directly and can thus better simulate vertical transport. In this study, we leverage the LES ARM Symbiotic Simulation and Observation (LASSO) large‐eddy simulations to simulate vertical transport of agricultural dust within the turbulent boundary layer using a modified version of the stochastic dispersion model FLEXPART‐WRF. We find that the modified model is better capable of simulating particle transport due to turbulence, and that particle size was the greatest factor in determining particle lifetime. Individual meteorology and particle density had intermediate effects upon particle transport, while release height had little effect upon simulation results. Finally, we utilize a quasi‐single column model (QSCM) approach to determine how our results compare to a parameterized treatment of turbulence. The QSCM simulations led to greater tracer transport out of the boundary layer, with ramifications for any studies utilizing a Lagrangian stochastic model to understand tracer dispersion. These results highlight the importance of accurately simulating turbulence for understanding particle transport.
Global Impact of Cloud Longwave Scattering in an Atmosphere‐Only General Circulation Model Simulation
Authors: Gu Boyan , Ren Tong , Kuo Chia‐Pang , Yang Ping , Bowman Kenneth 
Published: January 2021

AbstractMost general circulation models (GCMs) neglect cloud longwave scattering in pursuit of computational efficiency. This study implements the 2‐/4‐stream (2/4S) method, a relatively fast cloud longwave scattering treatment, in Community Atmospheric Model version 5 (CAM5) to analyze the impact of cloud longwave scattering on the large‐scale circulation. Two 45‐years‐long integrations are performed with prescribed sea surface temperature (SST). In the experiment run, cloud longwave scattering is included using the 2/4S method; in the control run, clouds only absorb in the longwave. The results show that cloud longwave scattering acts to enhance the cloud longwave (greenhouse) effect by reducing outgoing longwave radiation (OLR) and enhancing downward longwave irradiance at the surface. The OLR reduction is most significant over the tropics, where surface temperatures and cloud elevations are high. The surface downward irradiance increase is most significant over polar areas and the Tibetan Plateau, where cloud elevations are low and the air below clouds is dry. Inclusion of cloud longwave scattering enhances the Walker circulation, suggestive of the importance of diabatic radiative heating in the tropical circulation. Inclusion of cloud longwave scattering also appears to shift the eddy‐driven jet poleward in the austral summer in the Southern Hemisphere, suggesting that the cloud longwave effect plays a role in shaping the jet position. Persistent equatorward jet biases in GCMs may be reduced if cloud longwave scattering is considered.
Band-structure-engineered high-gain LWIR photodetector based on a type-II superlattice
Authors: Dehzangi Arash , Li Jiakai , Razeghi Manijeh 
Published: January 2021

AbstractThe LWIR and longer wavelength regions are of particular interest for new developments and new approaches to realizing long-wavelength infrared (LWIR) photodetectors with high detectivity and high responsivity. These photodetectors are highly desirable for applications such as infrared earth science and astronomy, remote sensing, optical communication, and thermal and medical imaging. Here, we report the design, growth, and characterization of a high-gain band-structure-engineered LWIR heterojunction phototransistor based on type-II superlattices. The 1/e cut-off wavelength of the device is 8.0 µm. At 77 K, unity optical gain occurs at a 90 mV applied bias with a dark current density of 3.2 × 10−7 A/cm2. The optical gain of the device at 77 K saturates at a value of 276 at an applied bias of 220 mV. This saturation corresponds to a responsivity of 1284 A/W and a specific detectivity of 2.34 × 1013 cm Hz1/2/W at a peak detection wavelength of ~6.8 µm. The type-II superlattice-based high-gain LWIR device shows the possibility of designing the high-performance gain-based LWIR photodetectors by implementing the band structure engineering approach.
Effect of time restricted eating on body weight and fasting glucose in participants with obesity: results of a randomized, controlled, virtual clinical trial
Authors: Peeke Pamela M. , Greenway Frank L. , Billes Sonja K. , Zhang Dachuan , Fujioka Ken 
Published: January 2021

AbstractBackgroundTime restricted eating (TRE) is an emerging dietary intervention for weight loss that is hypothesized to reinforce the metabolic benefits of nightly fasting/ketosis. This pilot study investigated the effectiveness of a daily 14-h metabolic fast (14:10 TRE beginning after dinner, a “fasting snack” at hour 12, and ending with breakfast 14 h later) combined with a commercial weight management program on body weight and fasting blood glucose (FBG) in individuals with obesity. We also investigated the effect of the low-calorie, high-fat, low-carbohydrate, and low-protein “fasting snack” on blood glucose.MethodsThis 8-week, randomized, controlled, clinical trial included men and women (BMI ≥ 30 kg/m2) between June and October 2020. Study procedures were conducted remotely. Participants were randomized to 14:10 or 12-h TRE (12:12, active comparator) and prescribed a diet (controlled for calories and macronutrient composition) and exercise program that included weekly customized counseling and support. The primary outcome was change from baseline in body weight in the 14:10 group.ResultsOf the 78 randomized participants, 60 (n = 30/group) completed 8 weeks. The LS mean change from baseline in weight in the 14:10 group was −8.5% (95% CI −9.6 to −7.4;P < 0.001) and −7.1% (−8.3 to −5.8;P < 0.001) in the 12:12 group (between group difference −1.4%; −2.7 to −0.2;P < 0.05). There was a statistically significant LS mean change from baseline to week 8 in FBG in the 14:10 group of −7.6 mg/dl (95% CI −15.1 to −0.1;P < 0.05) but not in the 12:12 group (−3.1 mg/dl, −10.0 to 3.7;P = NS). Both interventions resulted in a larger reduction in FBG in participants with elevated FBG (≥100 mg/dl) at baseline (bothP < 0.05).ConclusionsIn participants with obesity who completed 8 weeks of the 14:10 TRE schedule combined with a commercial weight loss program, there was statistically significant and clinically meaningful weight loss and improvements in FBG.
Prolactin receptor-driven combined luminal and epithelial differentiation in breast cancer restricts plasticity, stemness, tumorigenesis and metastasis
Authors: Shams Anwar , Binothman Najat , Boudreault Julien , Wang Ni , Shams Fuad , Hamam Dana , Tian Jun , Moamer Alaa , Dai Meiou , Lebrun Jean-Jacques , Ali Suhad 
Published: January 2021

AbstractDedifferentiation increased cellular plasticity and stemness are established derivers of tumor heterogeneity, metastasis and therapeutic failure resulting in incurable cancers. Therefore, it is essential to decipher pro/forward-differentiation mechanisms in cancer that may serve as therapeutic targets. We found that interfering with expression of the receptor for the lactogenic hormone prolactin (PRLR) in breast cancer cells representative of the luminal and epithelial breast cancer subtypes (hormone receptor positive (HR+) and HER2-enriched (HER2-E) resulted in loss of their differentiation state, enriched for stem-like cell subpopulations, and increased their tumorigenic capacity in a subtype-specific manner. Loss of PRLR expression in HR+ breast cancer cells caused their dedifferentiation generating a mesenchymal-basal-like phenotype enriched in CD44+ breast cancer stem-like cells (BCSCs) showing high tumorigenic and metastatic capacities and resistance to anti-hormonal therapy. Whereas loss of PRLR expression in HER2-E breast cancer cells resulted in loss of their luminal differentiation yet enriched for epithelial ALDH+ BCSC population showing elevated HER2-driven tumorigenic, multi-organ metastatic spread, and resistance to anti-HER2 therapy. Collectively, this study defines PRLR as a driver of precise luminal and epithelial differentiation limiting cellular plasticity, stemness, and tumorigenesis and emphasizing the function of pro/forward-differentiation pathways as a foundation for the discovery of anti-cancer therapeutic targets.
Multimodal sensory evaluation of neuropathic spinal cord injury pain: an experimental study
Authors: Opsommer Emmanuelle , Korogod Natalya , Stockinger Lenka , Landmann Gunther 
Published: January 2021

Abstract
Study design
An experimental study.

Objectives
To investigate the changes in somatosensory functions using the combined application of quantitative sensory testing (QST), contact heat-evoked potentials (CHEPs) and laser-evoked potentials (LEPs) studies in individuals with spinal cord injury (SCI) in relation to neuropathic pain (NeP).

Setting
Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.

Methods
Individuals with SCI were compared: 12 with NeP (SCI NeP) and 12 without NeP (SCI no NeP). Tools used were QST, CHEPs, LEPs and self-reported questionnaires. Tests were applied to the control (hand) and test (dermatome of altered sensation) sites, and compared to the able-bodied group.

Results
QST, LEPs and CHEPs assessments showed abnormalities both on the test and control sites, which did not differ between the groups with SCI. QST showed higher prevalence of allodynia in SCI NeP. CHEPs and LEPs demonstrated diminished amplitudes in both groups with SCI in comparison to able-bodied individuals. Only reaction time (RT) analysis revealed the difference of SCI NeP from the other two groups, expressed in partially preserved responses to the laser C-fibre stimulations.

Conclusions
Combination of assessments in our study allowed to examine spinothalamic and dorsal column functions in individuals with SCI. Changes in QST, CHEPs and LEPs were detected below the level of injury independent of NeP and at the control site indicating modifications in sensory processing rostral to the spinal lesion. Analysis of RT during laser stimulation could be an essential component when evaluating the somatosensory functions related to NeP in persons with SCI.
Comparative genomics reveals new functional insights in uncultured MAST species
Authors: Labarre Aurelie , López-Escardó David , Latorre Francisco , Leonard Guy , Bucchini François , Obiol Aleix , Cruaud Corinne , Sieracki Michael E , Jaillon Olivier , Wincker Patrick , Vandepoele Klaas , Logares Ramiro , Massana Ramon 
Published: January 2021

Abstract
Heterotrophic lineages of stramenopiles exhibit enormous diversity in morphology, lifestyle, and habitat. Among them, the marine stramenopiles (MASTs) represent numerous independent lineages that are only known from environmental sequences retrieved from marine samples. The core energy metabolism characterizing these unicellular eukaryotes is poorly understood. Here, we used single-cell genomics to retrieve, annotate, and compare the genomes of 15 MAST species, obtained by coassembling sequences from 140 individual cells sampled from the marine surface plankton. Functional annotations from their gene repertoires are compatible with all of them being phagocytotic. The unique presence of rhodopsin genes in MAST species, together with their widespread expression in oceanic waters, supports the idea that MASTs may be capable of using sunlight to thrive in the photic ocean. Additional subsets of genes used in phagocytosis, such as proton pumps for vacuole acidification and peptidases for prey digestion, did not reveal particular trends in MAST genomes as compared with nonphagocytotic stramenopiles, except a larger presence and diversity of V-PPase genes. Our analysis reflects the complexity of phagocytosis machinery in microbial eukaryotes, which contrasts with the well-defined set of genes for photosynthesis. These new genomic data provide the essential framework to study ecophysiology of uncultured species and to gain better understanding of the function of rhodopsins and related carotenoids in stramenopiles.
Newly discovered Asgard archaea Hermodarchaeota potentially degrade alkanes and aromatics via alkyl/benzyl-succinate synthase and benzoyl-CoA pathway
Authors: Zhang Jia-Wei , Dong Hong-Po , Hou Li-Jun , Liu Yang , Ou Ya-Fei , Zheng Yan-Ling , Han Ping , Liang Xia , Yin Guo-Yu , Wu Dian-Ming , Liu Min , Li Meng 
Published: January 2021

Abstract
Asgard archaea are widely distributed in anaerobic environments. Previous studies revealed the potential capability of Asgard archaea to utilize various organic substrates including proteins, carbohydrates, fatty acids, amino acids and hydrocarbons, suggesting that Asgard archaea play an important role in sediment carbon cycling. Here, we describe a previously unrecognized archaeal phylum, Hermodarchaeota, affiliated with the Asgard superphylum. The genomes of these archaea were recovered from metagenomes generated from mangrove sediments, and were found to encode alkyl/benzyl-succinate synthases and their activating enzymes that are similar to those identified in alkane-degrading sulfate-reducing bacteria. Hermodarchaeota also encode enzymes potentially involved in alkyl-coenzyme A and benzoyl-coenzyme A oxidation, the Wood–Ljungdahl pathway and nitrate reduction. These results indicate that members of this phylum have the potential to strictly anaerobically degrade alkanes and aromatic compounds, coupling the reduction of nitrate. By screening Sequence Read Archive, additional genes encoding 16S rRNA and alkyl/benzyl-succinate synthases analogous to those in Hermodarchaeota were identified in metagenomic datasets from a wide range of marine and freshwater sediments. These findings suggest that Asgard archaea capable of degrading alkanes and aromatics via formation of alkyl/benzyl-substituted succinates are ubiquitous in sediments.
Light stimulates anoxic and oligotrophic growth of glacial Flavobacterium strains that produce zeaxanthin
Authors: Liu Qing , Li Wei , Liu Di , Li Lingyan , Li Jie , Lv Na , Liu Fei , Zhu Baoli , Zhou Yuguang , Xin Yuhua , Dong Xiuzhu 
Published: January 2021

Abstract
Bacteria that inhabit glaciers usually produce carotenoids. Here, we report that a group of zeaxanthin-producing glacial Flavobacterium exhibited light-promoted growth. Of the tested 47 strains, 45 showed increased growths but two died under illumination at 50 μmol photon m−2 s−1. Light stimulation occurred mainly in either anoxic or nutrient-poor cultures, while the same levels of light promotion were found for that grown at 14 and 7 °C. Pigment assays identified overrepresentative zeaxanthin but trace retinal in the light promoted 45 strains, while flexirubin was exclusively in the light-lethal two. Genomic analysis revealed the gene cluster for zeaxanthin synthesis in the 45 strains, in which 37 strains also harbored the proteorhodopsin gene prd. Transcriptomic analysis found that light-induced expressions of both the zeaxanthin synthesis and proteorhodopsin genes. Whereas, deletion of the prd gene in one strain did not diminish light promotion, inhibition of zeaxanthin synthesis did. In comparison, no light promotion was determined in a glacier Cryobacterium luteum that produced a non-zeaxanthin-type carotenoid. Therefore, light stimulation on the glacial Flavobacterium is mostly likely related to zeaxanthin, which could provide better photoprotection and sustain membrane integrity for the organisms living in cold environments.