bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mid-term clinical and haemodynamic results after aortic valve replacement with the Trifecta bioprosthesis
Authors: Mortelé Augustijn , Dereu Alexander , Bové Thierry , François Katrien 
Published: July 2021

Abstract OBJECTIVESThe aim of this study was to evaluate the clinical and haemodynamic results after implantation of the Trifecta bioprosthesis.METHODSThis study is a retrospective analysis of all patients undergoing Trifecta aortic valve replacement between 01 January 2012 and 31 December 2017 at the Ghent University Hospital. Univariable and multivariable analyses were performed to identify predictors of valve- and procedure-related complications and mortality. The haemodynamic performance was analysed by longitudinal Doppler echocardiography.RESULTSThe mean age of the 182 patients was 77 [standard deviation (SD): 5.5] years; 54.9% were women. The mean follow-up was 39.8 (SD: 24.3) months. Overall survival at 1 and 5 years was 86% (SD: 3%) and 68% (SD: 4%), respectively, and overall freedom from structural valve deterioration was 100% and 98% at 1 and 5 years, respectively. There was no valve thrombosis nor early endocarditis. Urgent surgery was the only risk factor for early mortality in the multivariable analysis [P = 0.009, odds ratio 0.06, 95% confidence interval (CI) 0.01–0.5]. Preoperative atrial fibrillation was the most important predictor of late mortality (P = 0.001, hazard ratio 3.68, 95% CI 1.65–8.21). The average peak gradients were stable from discharge up to 1 and 5 years postoperatively [15 (SD: 6) and 17 (SD: 8) mmHg].CONCLUSIONSThese results confirm the excellent clinical performance of the Trifecta valve, particularly in an elderly age group. Through the 7-year follow-up period, low transvalvular gradients persisted, and only a few patients needed reoperation. Although structural valve degeneration occurred rarely, it was unrelated to valve size or age at implantation; therefore, further long-term follow-up remains mandatory.
Intraoperative neuromonitoring in thoracoscopic excision of brachial plexus schwannoma
Authors: Femia Federico , Junemann Carola , Ruffini Enrico , Guerrera Francesco 
Published: July 2021

AbstractMediastinal schwannoma arising from brachial plexus are rare, but their surgical treatment could be challenging with a minimally invasive approach, given their position. Furthermore, their proximity to brachial plexus nerve fibres raises the risk for postoperative upper limb deficits. A 72-year-old man presented mediastinal schwannoma arising from the T1 nerve root. Complete surgical excision was achieved via video-assisted thoracic surgery with the aid of intraoperative neuromonitoring, and no postoperative neurological deficit developed after the intervention. Using intraoperative neuromonitoring, radical minimally invasive surgical treatment can be safely achieved for mediastinal schwannoma arising from brachial plexus.
The mechanical origin of the radial shape in distichous phyllotaxy grass plants
Authors: Tokuyama Yoshiki , Koide Yohei , Onishi Kazumitsu , Hikichi Kiwamu , Omachi Miku , Takamure Itsuro , Kishima Yuji 
Published: July 2021

Abstract
Three-dimensional plant shapes are influenced by their phyllotaxy, which plays a significant role in their environmental adaptation. Grasses with distichous phyllotaxy have linearly aligned culms and usually have vertical fan-like shapes. Counterintuitively, some distichous phyllotaxy grasses have radial shapes. Here, we investigate the organ-level mechanism underlying radial shape development in the distichous phyllotactic wild rice species (Oryza rufipogon). Detailed time-course phenotyping and three-dimensional micro-computed tomography showed that changes in the elevation angle in the main culm and azimuth angle in the primary tillers contribute to radial shape development. To infer the mechanical basis of the shape change, we simulated the movements of culms controlled by different kinematic factors. The computational models predicted that the combination of movements, including that controlled by negative gravitropism, produces the overall radial shape. This prediction was experimentally assessed. The analysis using a near-isogenic line of the gene, PROG1 for prostrate growth and the gravitropic mutant (lazy1) showed an association between genes and our model parameters. Our findings provide a simple, yet substantial, kinematic model for how the shape in distichous phyllotaxy plants changes as part of their adaptation to the surrounding environment.
Quality gap in venous thromboembolism prophylaxis practices in inpatients: Assessment of prophylaxis practices in a University Hospital
Authors: Güven Alper Tuna , Altintop Sabri Engin , Özdede Murat , Uyaroğlu Oğuz Abdullah , Tanriöver Mine Durusu 
Published: July 2021

Abstract

Background
Venous thromboembolism (VTE) is a prevalent complication of inpatient care, causing high burden of morbidity and mortality. Prophylaxis reduces the events; thus, these practices are promoted. We aimed to assess the VTE prophylaxis practices in the general internal medicine wards of a tertiary-care university hospital and utilize these data to propose quality improvement projects.

Objective
Assess the pharmacological venous thromboembolism prophylaxis utilization by using the Padua Prediction Score and demonstrate the main determinants of inappropriate prophylaxis use.

Methods
Electronic medical records were used to collect data cross-sectionally from 1 January 2019 to 30 June 2019. Padua Prediction Score was used to assess the appropriateness of VTE prophylaxis. Underlying health conditions, hospitalization causes, anti-platelets and use of glucocorticoids were also assessed as confounding factors.

Results
A total of 295 patients were included. Higher proportion of patients who received VTE prophylaxis were obese and had higher rates of diabetes and coronary artery disease. Prophylaxis was more commonly utilized among patients who were elderly, obese, having an acute infection and/or rheumatologic disorder and prolonged bed rest (P ≤ 0.001, P = 0.01, P = 0.22 and P ≤ 0.001, respectively). Thirty-five patients (11.8%) received VTE prophylaxis, despite 89 patients (30.2%) were high-risk patients. In the high-risk group (n = 89), 27 patients (30.3%) received appropriate pharmacological prophylaxis, while 8 patients (3.9%) received VTE prophylaxis in the low-risk group (total n = 206). A considerable percentage of the high-risk population (69.6%) did not receive VTE prophylaxis.

Discussion
Underuse constitutes a major challenge in our hospital but differing from other institutions, overuse is not a significant issue. Further studies are needed whether VTE prophylaxis improvement implementations uniformly increase appropriate VTE use.
How to Hold Unjust Structures Responsible in International Relations
Authors: Srivastava Swati , Muscott Lauren 
Published: July 2021

Abstract
Recent public discourse and political theory center on “structural” approaches of assigning responsibility for injustice in contrast to an “interactional” perspective. The interactional approach corrects discrete harms between agents to return to a just baseline, whereas the structural approach casts a wider net implicating agents in harmful structures for systemic transformation. This theory note advances the understanding of structural responsibility in international relations by defending it against common critiques of underspecification and lack of targeted accountability. We argue that structural arguments are better understood as constituting a framework on the nature of injustice rather than a theory or descriptor of particular harms. We present a “framework, theory, action” heuristic, drawing from constructivism's evolution from a theory (like realism and liberalism) when it first appeared to a framework (like rationalism) more recently. Our framework heuristic makes available a fuller range of conceptual tools to hold unjust structures responsible, including through targeted blame and liability, and discards the need to invent new actions to discharge structural responsibility. Rather than settle on one definition of structural responsibility—what it means, where it is located, and how it is discharged—we direct scholars to the numerous ways structural responsibility may be theorized and enacted.
Advances on (+)-nootkatone microbial biosynthesis and its related enzymes
Authors: Li Xiao , Ren Jing-Nan , Fan Gang , Zhang Lu-Lu , Pan Si-Yi 
Published: July 2021

Abstract
(+)-Nootkatone is an important functional sesquiterpene and is comprehensively used in pharmaceutical, cosmetic, agricultural and food flavor industries. However, (+)-nootkatone is accumulated trace amounts in plants, and the demand for industry is mainly met by chemical methods which is harmful to the environment. The oxygen-containing sesquiterpenes prepared using microbial methods can be considered as “natural.” Microbial transformation has the advantages of mild reaction conditions, high efficiency, environmental protection, and strong stereoselectivity, and has become an important method for the production of natural spices. The microbial biosynthesis of (+)-nootkatone from the main precursor (+)-valencene is summarized in this paper. Whole-cell systems of fungi, bacteria, microalgae, and plant cells have been employed. It was described that the enzymes involved in the microbial biosynthesis of (+)-nootkatone, including cytochrome p450 enzymes, laccase, lipoxygenase, and so on. More recently, the related enzymes were expressed in microbial hosts to heterologous produce (+)-nootkatone, such as Escherichia coli, Pichia pastoris, Yarrowia lipolytica, and Saccharomyces cerevisiae. Finally, the development direction of research for realizing industrialization of microbial transformation was summarized and it provided many options for future improved bioprocesses.
Human neuromuscular junction three-dimensional organoid models and the insight in motor disorders
Authors: Zhang Kejing , Bai Lei , Xu Wentao , Shen Chengyong 
Published: July 2021

Abstract
The neuromuscular junction (NMJ), a peripheral synaptic connection between motoneurons and skeletal muscle fibers, controls movement. Dysregulation of NMJs has been implicated in various motor disorders. Because of their large size and easy accessibility, NMJs have been extensively investigated in the neuroscience field and have greatly contributed to our understanding of the fundamental principles of synapses in the central nervous system. Researchers have tried multiple ways to develop models to recreate NMJs. Rapid progress in the research and development of tissue-like organoids has made it possible to produce human NMJ three-dimensional (3D) models in vitro, providing an additional powerful strategy to study NMJs. Here, we introduce the most recent advances of human embryonic stem cell- or induced pluripotent stem cell-derived organoids to model 3D NMJs.
Evolution in X-ray analysis from micro to atomic scales in aberration-corrected scanning transmission electron microscopes
Authors: Watanabe M , Egerton R F 
Published: July 2021

AbstractX-ray analysis is one of the most robust approaches to extract quantitative information from various materials and is widely used in various fields ever since Raimond Castaing established procedures to analyze electron-induced X-ray signals for materials characterization ‘70 years ago’. The recent development of aberration-correction technology in a (scanning) transmission electron microscopes (S/TEMs) offers refined electron probes below the Å level, making atomic-resolution X-ray analysis possible. In addition, the latest silicon drift detectors allow complex detector arrangements and new configurational designs to maximize the collection efficiency of X-ray signals, which make it feasible to acquire X-ray signals from single atoms. In this review paper, recent progress and advantages related to S/TEM-based X-ray analysis will be discussed: (i) progress in quantification for materials characterization including the recent applications to light element analysis, (ii) progress in analytical spatial resolution for atomic-resolution analysis and (iii) progress in analytical sensitivity toward single-atom detection and analysis in materials. Both atomic-resolution analysis and single-atom analysis are evaluated theoretically through multislice-based calculation for electron propagation in oriented crystalline specimen in combination with X-ray spectrum simulation.
Visualization of Arabidopsis root system architecture in 3D by refraction-contrast X-ray micro-computed tomography
Authors: Kurogane Tomofumi , Tamaoki Daisuke , Yano Sachiko , Tanigaki Fumiaki , Shimazu Toru , Kasahara Haruo , Yamauchi Daisuke , Uesugi Kentaro , Hoshino Masato , Kamisaka Seiichiro , Mineyuki Yoshinobu , Karahara Ichirou 
Published: July 2021

Abstract
Plant roots change their morphological traits in order to adapt themselves to different environmental conditions, resulting in the alteration of the root system architecture. To understand this mechanism, it is essential to visualize the morphology of the entire root system. To reveal effects of long-term alteration of gravity environment on root system development, we have performed an experiment in the International Space Station using Arabidopsis plants and obtained dried root systems grown in rockwool slabs. The X-ray computed tomography (CT) technique using industrial X-ray scanners has been introduced to visualize the root system architecture of crop species grown in soil in 3D non-invasively. In the case of the present study, however, the root system of Arabidopsis is composed of finer roots compared with typical crop plants and rockwool is also composed of fibers having similar dimension to that of the roots. A higher spatial resolution imaging method is required for distinguishing roots from rockwool. Therefore, in the present study, we tested refraction-contrast X-ray micro-CT using coherent X-ray optics available at the beamline of the synchrotron radiation facility SPring-8 for bio-imaging. We have found that a wide field of view but with low resolution obtained at the experimental Hutch 3 of this beamline provided an overview map of the root systems, while a narrow field of view but with high resolution obtained at the experimental Hutch 1 provided an extended architecture of the secondary roots, by a clear distinction between roots and individual rockwool fibers, resulting in the successful tracing of these roots from their basal regions.
Atypical primary hyperparathyroidism due to parathyroid lipoadenoma: a case report
Authors: Cammarata Francesco , Yakushkina Al’ona , Pennacchi Luca , Carsana Luca , Zerbi Pietro , Montecamozzo Giulio , Danelli Piergiorgio 
Published: July 2021

Abstract
Parathyroid lipoadenoma is a very rare cause of primary hyperparathyroidism. Preoperative imaging techniques often fail to detect such lesions, and even during surgery they can be misinterpreted just as fat tissue. A 62-year-old woman clinically monitored for primary hyperparathyroidism, with hypertension and a left nephrectomy for hydrouretheronephrosis caused by recurrent kidney stones. A neck ultrasound showed a nodule consistent with left parathyroid of 9 × 5 mm, which was not confirmed on single-photon-emission computed tomography/computed tomography (CT) scan. On surgery, a voluminous lesion with adipose appearance and texture was removed. Frozen sections and intraoperative parathyroid hormone (PTH) confirmed such lesion to be a parathyroid lipoadenoma. Parathyroid lipoadenomas are difficult to localize preoperatively. Sometimes they can be seen by ultrasound scan as hyperechoich lesion, but scintigraphy and CT often fail to identify them. Only the awareness of such lesions and the use of intraoperative PTH can avoid unnecessary extensive cervical exploration.
Dissipative dark matter on FIRE – I. Structural and kinematic properties of dwarf galaxies
Authors: Shen Xuejian , Hopkins Philip F , Necib Lina , Jiang Fangzhou , Boylan-Kolchin Michael , Wetzel Andrew 
Published: July 2021

ABSTRACT
We present the first set of cosmological baryonic zoom-in simulations of galaxies including dissipative self-interacting dark matter (dSIDM). These simulations utilize the Feedback In Realistic Environments galaxy formation physics, but allow the dark matter to have dissipative self-interactions analogous to standard model forces, parametrized by the self-interaction cross-section per unit mass, (σ/m), and the dimensionless degree of dissipation, 0 &lt; fdiss &lt; 1. We survey this parameter space, including constant and velocity-dependent cross-sections, and focus on structural and kinematic properties of dwarf galaxies with $M_{\rm halo} \sim 10^{10-11}{\, \rm M_\odot }$ and $M_{\ast } \sim 10^{5-8}{\, \rm M_\odot }$. Central density profiles (parametrized as ρ ∝ rα) of simulated dwarfs become cuspy when $(\sigma /m)_{\rm eff} \gtrsim 0.1\, {\rm cm^{2}\, g^{-1}}$ (and fdiss = 0.5 as fiducial). The power-law slopes asymptote to α ≈ −1.5 in low-mass dwarfs independent of cross-section, which arises from a dark matter ‘cooling flow’. Through comparisons with dark matter only simulations, we find the profile in this regime is insensitive to the inclusion of baryons. However, when $(\sigma /m)_{\rm eff} \ll 0.1\, {\rm cm^{2}\, g^{-1}}$, baryonic effects can produce cored density profiles comparable to non-dissipative cold dark matter (CDM) runs but at smaller radii. Simulated galaxies with $(\sigma /m) \gtrsim 10\, {\rm cm^{2}\, g^{-1}}$ and the fiducial fdiss develop significant coherent rotation of dark matter, accompanied by halo deformation, but this is unlike the well-defined thin ‘dark discs’ often attributed to baryon-like dSIDM. The density profiles in this high cross-section model exhibit lower normalizations given the onset of halo deformation. For our surveyed dSIDM parameters, halo masses and galaxy stellar masses do not show appreciable difference from CDM, but dark matter kinematics and halo concentrations/shapes can differ.
A differentiable N-body code for transit timing and dynamical modelling – I. Algorithm and derivatives
Authors: Agol Eric , Hernandez David M , Langford Zachary 
Published: July 2021

ABSTRACT
When fitting N-body models to astronomical data – such as transit times, radial velocity, and astrometric positions at observed times – the derivatives of the model outputs with respect to the initial conditions can help with model optimization and posterior sampling. Here, we describe a general purpose symplectic integrator for arbitrary orbital architectures, including those with close encounters, which we have recast to maintain numerical stability and precision for small step sizes. We compute the derivatives of the N-body coordinates and velocities as a function of time with respect to the initial conditions and masses by propagating the Jacobian along with the N-body integration. For the first time, we obtain the derivatives of the transit times with respect to the initial conditions and masses using the chain rule, which is quicker and more accurate than using finite differences or automatic differentiation. We implement this algorithm in an open source package, NbodyGradient.jl, written in the Julia language, which has been used in the optimization and error analysis of transit-timing variations in the TRAPPIST-1 system. We present tests of the accuracy and precision of the code, and show that it compares favourably in speed to other integrators that are written in C.
Low-surface-brightness spheroidal galaxies as Milgromian isothermal spheres
Authors: Sanders R H 
Published: July 2021

ABSTRACT
I consider a sample of eight pressure-supported low-surface-brightness galaxies in terms of Milgrom’s modified Newtonian dynamics (MOND). These objects include seven nearby dwarf spheroidal galaxies – Sextans, Carina, Leo II, Sculptor, Draco, Leo I, Fornax, and the ultra-diffuse galaxy DF44. The objects are modelled as Milgromian isotropic isothermal spheres characterized by two parameters that are constrained by observations: the constant line-of-sight velocity dispersion and the central surface density. The velocity dispersion determines the total mass, and, with the implied mass-to-light ratio, the central surface brightness. This then specifies the radial run of surface brightness over the entire isothermal sphere. For these objects, the predicted radial distribution of surface brightness is shown to be entirely consistent with observations. This constitutes a success for MOND that is independent of the reduced dynamical mass.
Reappraising Choice in Addiction: Novel Conceptualizations and Treatments for Tobacco Use Disorder
Authors: Palmer Amanda M , Toll Benjamin A , Carpenter Matthew J , Donny Eric C , Hatsukami Dorothy K , Rojewski Alana M , Smith Tracy T , Sofuoglu Mehmet , Thrul Johannes , Benowitz Neal L 
Published: July 2021

Abstract
The introduction of alternative nicotine and tobacco products (such as e-cigarettes, heat-not-burn devices, nicotine pouches) warrants an updated framework from which to conceptualize tobacco use disorder (TUD). The following review provides considerations for TUD within the context of novel products. Historically, the tobacco industry falsely claimed that cigarettes were not addictive or harmful and that those who smoked simply chose to do so. This generated an inaccurate lay perception that smoking is a free or informed choice. Research on nicotine pharmacology demonstrates the powerful addictive potential of nicotine, which is shaped by dose, speed of delivery, and other constituents generated. In addition, non-pharmacologic reinforcers motivate and maintain tobacco use behaviors for both traditional cigarettes and novel products. The negative consequences of combustible tobacco use are well known; however, these outcomes may differ for alternative products. Strategies used for combustible product cessation may be adapted for novel products, and treatment recommendations for TUD should be made within the context of a harm reduction framework wherein alternative product use may be the desired outcome. Providers must therefore be willing to modify their perceptions of products and treatment recommendations accordingly. Better public health outcomes are accomplished through promotion of abstinence from combustible smoking. For those who cannot wean from nicotine entirely, switching to less risky modes of delivery might be a secondary goal, with an eventual aim of stopping use of the alternative product.
Implications: Given the advent of novel, alternative tobacco products, tobacco use disorder (TUD) must be conceptualized within a contemporary framework that includes harm reduction and alternative outcomes. The unique contributions of nicotine pharmacology, non-pharmacologic reinforcers, and consequences of use can be used to inform treatments for TUD with the ultimate goal of improving the health of individuals who use tobacco.