bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personality Functioning in Inpatients With Eating Disorders: Association With Symptom Severity and Treatment Outcome
Authors: Heinzmann Sophia , Etzler Sonja , Hartmann Armin , Klein Eva M. , Herpertz Stephan , Pape Magdalena , Heinzmann Stanislav , Doering Stephan , Hofmann Tobias , Rose Matthias , Imbierowicz Katrin , Geiser Franziska , Bierling Antonie , Weidner Kerstin , Rademacher Jörg , Michalek Silke , Morawa Eva , Erim Yesim , Skoda Eva‐Maria , Teufel Martin , Peters Eva Milena Johanne , Kruse Johannes , von Boetticher Dirk , Herrmann‐Lingen Christoph , Noehre Mariel , de Zwaan Martina , Dinger Ulrike , Friederich Hans‐Christoph , Niecke Alexander , Albus Christian , Zwerenz Rüdiger , Beutel Manfred , Roenneberg Casper , Henningsen Peter , Stein Barbara , Waller Christiane , Hake Karsten , Spitzer Carsten , Stengel Andreas , Zipfel Stephan , Weimer Katja , Gündel Harald , Kessler Henrik , Spieler Derek , Lahmann Claas , Zeeck Almut 
Published: February 2025

ABSTRACTObjectiveImpairment in personality functioning (PF) has been linked to a number of mental disorders, including eating disorders (EDs). However, the precise relationship between PF and symptom severity, as well as the potential impact on outcome, remains unclear. The study aimed to analyse the association of PF and its change with severity of ED symptomatology as well as outcome of hospital treatment.MethodThe sample consisted of 397 patients with EDs, treated in 19 university hospitals for Psychosomatic Medicine and Psychotherapy in Germany between 1/2019 and 12/2020. PF was measured with the Structure Questionnaire of the Operationalised Psychodynamic Diagnosis (OPD‐SQ, short version), eating psychopathology with the ED examination questionnaire (EDE‐Q). Outcome was defined as a change in the EDE‐Q total score. We used Latent Change Score Modelling to analyse changes in ED pathology during treatment and a 1‐year follow‐up period.ResultsA higher level of impairment in PF at admission correlated with more eating psychopathology and a less favourable outcome. Additionally, greater improvement in PF correlated with greater improvements in ED symptomatology at discharge.ConclusionImpairment in PF needs to be part of diagnostic assessments and should be considered an important treatment target for psychotherapeutic interventions.Trial RegistrationThe MEPP study was registered in the German Clinical Trials Register (DRKS, www.drks.de; ID: DRKS00016412)
A WPOD‐Kriging Reduced‐Order Method for Parametric CFD Simulations
Authors: Xia Zhehao , Wu Yizhong 
Published: February 2025

ABSTRACTHigh‐fidelity computational fluid dynamics (CFD) simulation usually carries a heavy computational burden, especially for parametric CFD simulations requiring multiple calculations. To address this challenge, researchers have developed reduced‐order modeling (ROM) to significantly decrease the computational burden by building a simplified model. This article proposes a hybrid method of weighted proper orthogonal decomposition and Kriging, a novel reduced‐order method. This method improves the accuracy of the reduced‐order model by assigning appropriate weights to the samples while estimating the specific design parameters. The main innovation of this work is the development of the optimized method for generating the weights. Firstly, the leave‐one‐out method is employed to divide the samples into the training set and test set, and the multivariate Gaussian distribution is used to convert the Euclidean distance between the training set and test set into weight. Then, we adopt the WPOD‐Kriging method to construct a reduced‐order model using the training set. This model is compared with the test set to obtain the error. By repeatedly resetting the training set and the test set, we receive multiple errors and average them to calculate the global error. This process involves an important parameter, which is the covariance matrix of multivariate Gaussian distribution. We can generate the optimal covariance matrix by minimizing the global error to achieve the optimized method for generating the weights. The efficacy of the WPOD‐Kriging method is validated through three parametric CFD simulations. Compared to other similar approaches, the proposed method offers a more accurate reduced‐order model.
Relationship Between FODMAP Diet and Irritable Bowel Syndrome: A Mendelian Randomization Study
Authors: Wang Lu , Cao Wei , Zheng Qian‐Hua , Li Dehua , Hou Yujun , Chen Shuai , Luo Fangli , Xiao Xianjun , Chen Ying , Li Ying , Zhou Siyuan 
Published: February 2025

ABSTRACTThere is some evidence of a link between fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet and irritable bowel syndrome (IBS). However, few studies have analyzed the relationship between specific dietary intakes and IBS using Mendelian randomization (MR). Exposure and outcome datasets were sourced from the IEU Open GWAS project. Genetic variants significantly associated with 28 dietary intakes at a genome‐wide level were selected as instrumental variables. Summary statistics for the target outcome of IBS were obtained with a sample of 187,028 European individuals (4605 cases, 182,423 controls). Univariable and multivariable MR analyses were conducted to estimate the overall and independent MR associations after adjustment for genetic liability to intestinal flora. Genetic predispositions to six of 28 dietary intakes were associated with a decreased risk of IBS, including dried fruit, beef, cereal, lobster/crab, cereal, feta, and coffee, while cherry and poultry intake were associated with an increased risk of IBS. Three of eight associations persisted after adjusting for genetically predicted intestinal flora, and multivariable MR analysis identified that salad/raw vegetable intake was associated with a decreased risk of IBS. Twenty of 28 dietary intakes did not remain significantly associated after adjustment for intestinal flora. This study provides MR evidence supporting causal associations between FODMAP dietary intakes and IBS.
Fermented Royal Jelly Enriched With 10‐Hydroxydecanoic Acid and Its Potential for Enhancing Mucosal Immunity
Authors: Itatani Hayate , Yamaki Ayanori , Konishi Kaori , Okamoto Hideto , Okumura Nobuaki , Shigematsu Norihiro , Misumi Shogo , Takenaka Shinji 
Published: February 2025

ABSTRACTRoyal jelly (RJ) is known to contain 10‐hydroxydecanoic acid (10HDAA), which has been shown to have immune activation properties, including the promotion of M cell differentiation. However, the natural concentration of 10HDAA in RJ is relatively low. To enhance the functional use of RJ as an immunostimulatory food ingredient, this study aimed to increase its 10HDAA content using bacteria capable of converting 10‐hydroxy‐2‐decenoic acid (10H2DA) to 10HDAA in RJ. A lactic acid bacterium, Lactobacillus panisapium, was isolated from the digestive tract of queen bees and demonstrated a high capacity to convert 10H2DA to 10HDAA. Using the isolated strain, fermented RJ (fRJ) with a fivefold increase in 10HDAA content was produced compared to raw RJ. Preliminary evaluations of fRJ's immune‐stimulating effects revealed significant benefits, including enhanced M cell differentiation, activation of macrophage phagocytic ability, and increased immunoglobulin (Ig) A secretion in individuals with reduced salivary IgA levels. Safety assessments confirmed that fRJ is safe for consumption. In summary, fRJ enriched with 10HDAA was produced and demonstrated potential as an immune‐stimulating food.
Evaluating the Potential of Gamma‐Glutamylcysteine and Glutathione as Substitutes for SO2 in White Wine
Authors: Guruk Mumine , Fickers Patrick , Agirman Bilal , Darıcı Merve , Erten Huseyin 
Published: February 2025

ABSTRACTSulfur dioxide (SO2) is the most common additive used in winemaking with its antimicrobial and antioxidant properties. However, in recent years, there has been an increasing tendency to reduce the use of excessive SO2 in wine due to its negative effects on human health and organoleptic characteristics. Therefore, the aim of this study was to evaluate the potential use of glutathione (GSH) and its precursor, gamma‐glutamyl‐cysteine (gGC), which are known as strong antioxidants, for substituting SO2 in white wines. The Turkish indigenous white grape cultivar, Narince (Vitis vinifera), was used to produce white wine. The wines with additions (SO2, gGC, and GSH) and those without (control) were matured for 2 months. As a result, the protective effects of gGC and GSH additions on phenolic compounds, as well as their ability to reduce browning in white wine, were demonstrated. The addition of gGC and GSH enhanced the amount of esters and higher alcohols, improving the wine's aroma. In conclusion, gGC and GSH—particularly gGC—showed great potential as SO2 replacements in wine.
Pricing Basket Spread Options With Default Risk Under GARCH‐Jump Models
Authors: Dong Dingding , Qian Xianda , Wang Xingchun 
Published: February 2025

ABSTRACTIn this article, we consider basket spread options with default risk in a pricing model, where GARCH‐jump processes are employed to describe the dynamics of all the underlying assets, and default risk is incorporated in a reduced form model. After successfully deriving the approximate pricing formula, we utilize the average cumulative default rates provided by Moody's spanning from 1970 to 2015 to estimate the parameters in the default intensity. Finally, we illustrate the impact of jump risk and default risk on basket spread options after checking the accuracy and efficiency of the approximate prices via Monte Carlo simulation methods.
Influence of a nationwide colorectal cancer screening program on the incidence of synchronous colorectal peritoneal metastases
Authors: Galanos Laskarina J. K. , Rijken Anouk , Elferink Marloes A. G. , Kok Niels F. M. , van Erning Felice N. , De Hingh Ignace H. J. T. 
Published: February 2025

AbstractThis study aims to assess the influence of colorectal cancer screening on the incidence of synchronous colorectal peritoneal metastases (CPM). Patients diagnosed with CPM between 2009 and 2022 were selected from the Netherlands Cancer Registry. Crude rates of the observed and expected CPM incidence were calculated per 100,000 individuals and compared. Expected incidence was extrapolated from the incidence in the years prior to screening invitation. In total, 9,238 patients with CPM were included. For the screen‐eligible population (55–75 years), the observed CPM incidence increased from 5.1 (2009) to 7.0 before screening initiation (2013) (Annual percent change [APC] 8.2%, p = .014). Since the start of screening, the observed CPM incidence stabilized: 8.8 (2014) to 8.9 (2022) (APC −1.0%, p = .159). Within the total population, the observed CPM incidence before screening showed an increase from 3.6 (2009) to 4.0 (2013) (APC 3.4%, p = .050). Since screening, a decrease in CPM incidence was observed from 4.4 (2014) to 3.5 (2022) (APC −2.2%, p = .010). The observed and expected number of CPM differed significantly in the screen‐eligible population (6,437 observed vs. 7,992 expected individuals; p < .001) and in the overall Dutch population (9,238 observed vs. 10,440 expected individuals; p < .001). In conclusion, a declining trend was observed in the incidence of CPM in the Dutch population since the start of colorectal cancer screening. The observed incidence was lower compared to the expected incidence, both in the screen‐eligible population and in the overall population. These findings suggest that screening results in a decrease of patients diagnosed with CPM possibly resulting in an improved survival of colorectal cancer patients.
Analysis of β‐Catenin Signalling Activity Suggests Differential Regulation of Ontogenetically Distinct Dentate Granule Neuron Populations
Authors: Billmann Charlotte , Schäffner Iris , Heppt Jana , Lie D. Chichung 
Published: February 2025

ABSTRACTIn mammals, the dentate gyrus of the hippocampus is one of the few regions where neurogenesis continues throughout life. As a result, the dentate gyrus harbours neurons of ontogenetically different origin. Notably, ontogenetically different dentate granule neurons (DGNs) are morphologically distinct and fulfil specialized functions in hippocampal information processing and plasticity. Development of adult‐born DGNs is tightly controlled by signals released by the complex cellular environment of the adult dentate gyrus. In mice, an adult‐like cytoarchitecture of the dentate gyrus is observed only after postnatal Week 2. The question therefore arises when the signalling environment controlling adult neurogenesis is established and whether development of ontogenetically distinct DGNs is subject to the same regulatory pathways. Here, we analyse BATGAL reporter mice to determine the temporal development of β‐catenin‐signalling activity in the murine DGN lineage. We show that the β‐catenin‐signalling pattern, which is essential for precise dendritogenesis and neuronal maturation in adulthood, emerges only around 2 weeks after birth and continues to be refined over the next weeks. These results indicate that the signalling environment controlling adult neurogenesis is only gradually established and suggest that the development of ontogenetically distinct DGNs is controlled by different mechanisms.
Living‐donor liver transplantation using donors older than 50 years of age: Recipient criteria and donor risk: A multicenter study of Japanese Society of Hepato‐Biliary‐Pancreatic Surgery
Authors: Toshima Takeo , Yoshizumi Tomoharu , Takada Yasutsugu , Ito Takashi , Shinoda Masahiro , Takahara Takeshi , Ishido Keinosuke , Takamura Hiroyuki , Taketomi Akinobu , Chiba Naokazu , Nakamura Masafumi , Shirabe Ken , Endo Itaru 
Published: February 2025

AbstractBackgroundFew published reports have addressed the feasibility of living‐donor liver transplantation (LDLT) using elderly donors. We aimed to examine LDLT outcomes in elderly donors and identify clinical factors impacting safely conducted LDLT.MethodsThis study was conducted in collaboration with the Japanese Society of Hepatobiliary‐Pancreatic Surgery. Data were collected from 140 patients who underwent LDLT using donors aged ≥50 years between 2013 and 2017 at nine collaborating hospitals.ResultsThe 1‐, 3‐, and 5‐year graft survival rates in recipients after LDLT employing elderly donors were 84.3%, 78.5%, and 76.3%, respectively, with 6‐month mortality of 12.1%. Specific recipient‐donor age combinations did not emerge as adverse prognostic factors. A total of 32 recipients (22.9%) had major complications requiring reoperation after LDLT, and 15 donors (10.7%) had major complications of Clavien–Dindo grade ≥II. Multivariate analysis revealed that graft‐to‐recipient weight ratio (GRWR) <0.84% and neutrophil‐to‐lymphocyte ratio (NLR) >6.6 were independent predictors of 6‐month graft loss after LDLT.ConclusionLDLT using elderly donors aged ≥50 years has acceptable graft survival and morbidity rates, and donor age >50 years should not be an absolute contraindication for LDLT. In LDLT involving elderly donors, it is crucial to consider that GRWR <0.84% and NLR >6.6 are adverse prognostic factors. Addressing these factors is necessary to enhance the prognosis, aligning with the increasing public demand for this surgical procedure.
Diurnal Pattern of Heat Stress Over South Asia: A Wet Bulb Globe Temperature‐Based Analysis From 1984 to 2023
Authors: Khan Najeebullah , Kamruzzaman Mohammad , Shahid Shamsuddin 
Published: February 2025

ABSTRACTAssessing the diurnal characteristics of heat stress is crucial for understanding its daily dynamics and impacts. This study evaluates various diurnal characteristics of heat stress using the Wet Bulb Globe Temperature (WBGT) over South Asia from 1984 to 2023. The Copernicus Climate Change Service hourly ERA5 dataset was used to calculate the WBGT using the Liljegren method to assess the hourly and daily heat stress, heatwave events, duration and diurnal range for different WBGT thresholds. The results revealed significant disparities in heat stress in different South Asian regions. The western and southeastern regions are more susceptible to extreme WBGT (≥ 32.2°C), while severe WBGT (≥ 31.1°C and < 32.2°C) predominantly affected central and eastern Pakistan and southern India. The western part of South Asia experiences an average of 5.8 heatwave events, with a cumulative total of 580 h. The diurnal range indicated a WBGT range of more than 8°C in western and southeastern regions. Conversely, the areas with no heat stress are predominantly located in the Himalayas and northern Afghanistan. The average annual extreme WBGT hours in western South Asia increased by 120 h between the early (1984–2003) and late (2004–2023) periods, while the extreme WBGT days increased by 15 days. Other characteristics of WBGT also increased in the recent decades compared to 1984–2003, suggesting the implementation of measures to mitigate future WBGT increases. These findings highlight the urgent need for adaptive strategies to address escalating heat stress in the region, especially in vulnerable and highly populated areas of South Asia.
Simultaneous Ultraviolet Photoacoustic and Auto‐Fluorescence Microscopy for High‐Contrast Histological Imaging
Authors: Li Xiufeng , Huang Bingxin , Lo Claudia T. K. , Liu Chengbo , Wong Terence T. W. 
Published: February 2025

AbstractUltraviolet (UV) photoacoustic microscopy has attracted lots of attention since it can provide histological images for disease diagnosis without any tissue processing or staining, holding great potential for rapid histopathology in hospitals. However, sometimes, the nuclear contrast in the images is relatively low due to the high UV absorption of various surrounding biomolecules (e.g., heme, myoglobin, lipids, etc.), resulting in low diagnostic accuracy. Here, a label‐free dual‐modality imaging system with ultraviolet photoacoustic and auto‐fluorescence (PAAF) microscopy is proposed, which can obtain photon absorption‐induced PA and AF images simultaneously using only one UV pulsed laser. With the opposite contrast acquired in the PA and AF images and the image fusion technique, this proposed PAAF microscopy enables high‐contrast and high‐sensitivity histological imaging for various tissues, even under a low excitation energy of 0.7 nJ and a high pulse‐to‐pulse energy fluctuation of ≈30%. Mouse brain, kidney, liver, lung, and human lung tissues processed by different clinical protocols have been imaged to demonstrate the versatility of PAAF microscopy, showing its promising applications in surgical pathology.
Addition of anti‐PD‐1 immunotherapy to BRAF inhibitor‐based targeted therapy improves real‐world survival and delays brain metastases in patients with BRAFV600‐mutant advanced melanoma: a multicenter cohort study
Authors: Wu Junwan , Ding Qiuyue , Zhang Qiong , Chen Qianqi , Wen Xizhi , Ding Ya , Li Jingjing , Chen Ziluan , Zhang Tao , Wang Jiuhong , Huang Fuxue , Jiang Hang , Chen Linbin , Zhou Qiming , Li Ke , Zhang Xiaoshi , Li Dandan 
Published: February 2025

AbstractAnti‐PD‐1 immunotherapy and targeted therapy (TT) represent two major therapeutic modalities for BRAFV600‐mutant advanced melanoma, but the efficacy of combination therapy in Asian populations remains unknown. Asian melanoma patients differ significantly from Caucasians in tissue subtypes, pathogenesis and response to treatment. We retrospectively analyzed data of BRAFV600‐mutant advanced melanoma patients treated with first‐line vemurafenib (V) ± anti‐PD‐1 or dabrafenib+trametinib (D+T) ± anti‐PD‐1 between 2014 and 2023 from three centers in China. 178 patients were included, with V (n = 45), D+T (n = 51), V+anti‐PD‐1 (n = 39) and D+T+anti‐PD‐1 (n = 43). The median PFS (21.9 vs. 11.1 months, p < 0.001), OS (NR vs. 32.6 months, p = 0.027), and DoR (20.0 vs. 8.4 months, p = 0.002) were significantly prolonged with D+T+anti‐PD‐1 versus D+T. Addition of anti‐PD‐1 to V also significantly prolonged PFS, OS, and DoR (p < 0.001). V+anti‐PD‐1 was superior to D+T in terms of PFS (15.0 vs. 11.1 months, p = 0.007) and DoR (18.0 vs. 8.4 months, p = 0.013), and was comparable to D+T+anti‐PD‐1. Addition of anti‐PD‐1 to BRAF inhibitor‐based TT was associated with lower incidence of brain metastases (p = 0.032). Addition of anti‐PD‐1 to BRAF inhibitor‐based TT appears to be a safe and effective treatment option, conferring a survival benefit and delaying the onset brain metastases in patients with BRAFV600‐mutant advanced melanoma.
Early‐life antibiotic exposure aggravates hepatic steatosis through enhanced endotoxemia and lipotoxic effects driven by gut Parabacteroides
Authors: Zhang Xi , Chan Darren Chak Lun , Zhu Jie , Sin Daniel Zhen Ye , Peng Ye , Wong Matthew Kwok Leong , Zhu Wenyi , Tsui Yee , Haqq Andrea M. , Ting Joseph Y. , Kozyrskyj Anita , Chan Francis Ka Leung , Ng Siew Chien , Tun Hein Min 
Published: February 2025

AbstractCompelling evidence supports a link between early‐life gut microbiota and the metabolic outcomes in later life. Using an early‐life antibiotic exposure model in BALB/c mice, we investigated the life‐course impact of prenatal and/or postnatal antibiotic exposures on the gut microbiome of offspring and the development of metabolic dysfunction‐associated steatotic liver disease (MASLD). Compared to prenatal antibiotic exposure alone, postnatal antibiotic exposure more profoundly affected gut microbiota development and succession, which led to aggravated endotoxemia and metabolic dysfunctions. This was primarily resulted from the overblooming of gut Parabacteroides and hepatic accumulation of cytotoxic lysophosphatidyl cholines (LPCs), which acted in conjunction with LPS derived from Parabacteroides distasonis (LPS_PA) to induce cholesterol metabolic dysregulations, endoplasmic reticulum (ER) stress and apoptosis. Integrated serum metabolomics, hepatic lipidomics and transcriptomics revealed enhanced glycerophospholipid hydrolysis and LPC production in association with the upregulation of PLA2G10, the gene controlling the expression of the group X secretory Phospholipase A2s (sPLA2‐X). Taken together, our results show microbial modulations on the systemic MASLD pathogenesis and hepatocellular lipotoxicity pathways following early‐life antibiotic exposure, hence help inform refined clinical practices to avoid any prolonged maternal antibiotic administration in early life and potential gut microbiota‐targeted intervention strategies.