bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Motion‐guided Interface for Modeling 3D Multi‐functional Furniture
Authors: Chen Minchan , Lau Manfred 
Published: November 2021

AbstractWhile non‐expert 3D design systems are helpful for performing conceptual design, most existing works focused on modeling static objects. However, the 3D modeling interfaces can include more interactions between the user and the models that are dynamic (and can be interacted with). In this paper, we propose a 3D modeling system for the conceptual design of interactable multi‐functional furniture. Our contribution is in the design and development of a motion‐guided interface. The key idea is that users should create interactable furniture components as if they are interacting with them with their hands. We conducted a preliminary user study to explore users’ preferred hand gestures for creating various dynamic furniture components, implemented a 3D modeling system with the preferred gestures as a basis for the motion‐guided user interface, and conducted an evaluation user study to demonstrate that our user interface is user‐friendly and efficient for novice designers to perform conceptual furniture designs.
UprightRL: Upright Orientation Estimation of 3D Shapes via Reinforcement Learning
Authors: Chen Luanmin , Xu Juzhan , Wang Chuan , Huang Haibin , Huang Hui , Hu Ruizhen 
Published: November 2021

AbstractIn this paper, we study the problem of 3D shape upright orientation estimation from the perspective of reinforcement learning, i.e. we teach a machine (agent) to orientate 3D shapes step by step to upright given its current observation. Unlike previous methods, we take this problem as a sequential decision‐making process instead of a strong supervised learning problem. To achieve this, we propose UprightRL, a deep network architecture designed for upright orientation estimation. UprightRL mainly consists of two submodules: an Actor module and a Critic module which can be learned with a reinforcement learning manner. Specifically, the Actor module selects an action from the action space to perform a point cloud transformation and obtain the new point cloud for the next environment state, while the Critic module evaluates the strategy and guides the Actor to choose the next stage action. Moreover, we design a reward function that encourages the agent to select action which is conducive to orient model towards upright orientation with a positive reward and negative otherwise. We conducted extensive experiments to demonstrate the effectiveness of the proposed model, and experimental results show that our network outperforms the state‐of‐the‐art. We also apply our method to the robot grasping‐and‐placing experiment, to reveal the practicability of our method.
Synthesizing Geologically Coherent Cave Networks
Authors: Paris A. , Guérin E. , Peytavie A. , Collon P. , Galin E. 
Published: November 2021

AbstractWe present a geologically‐based method to generate complex karstic networks. Karsts are a type of landscape formed by the dissolution of highly soluble rocks (generally limestones). In particular, they are characterized by complex underground networks made of varieties of tunnels and breakout chambers with stalagmites and stalactites. Our method computes skeletons of karstic networks by using a gridless anisotropic shortest path algorithm according to field data of the underground system (such as inlets and outlets), geomorphological features and parameters such as faults, inception horizons, fractures, and permeability contrasts. From this skeleton, we define the geometry of the conduits as a signed distance function construction tree combining primitives with blending and warping operators. Our framework provides multiple levels of control, allowing us to author both the structure of the karstic network and the geometric cross‐section shapes and details of the generated conduits.
Manhattan‐world urban building reconstruction by fitting cubes
Authors: He Zhenbang , Wang Yunhai , Cheng Zhanglin 
Published: November 2021

AbstractThe Manhattan‐world building is a kind of dominant scene in urban areas. Many existing methods for reconstructing such scenes are either vulnerable to noisy and incomplete data or suffer from high computational complexity. In this paper, we present a novel approach to quickly reconstruct lightweight Manhattan‐world urban building models from images. Our key idea is to reconstruct buildings through the salient feature ‐ corners. Given a set of urban building images, Structure‐from‐Motion and 3D line reconstruction operations are applied first to recover camera poses, sparse point clouds, and line clouds. Then we use orthogonal planes detected from the line cloud to generate corners, which indicate a part of possible buildings. Starting from the corners, we fit cubes to point clouds by optimizing corner parameters and obtain cube representations of corresponding buildings. Finally, a registration step is performed on cube representations to generate more accurate models. Experiment results show that our approach can handle some nasty cases containing noisy and incomplete data, meanwhile, output lightweight polygonal building models with a low time‐consuming.
18F‐fluorodeoxy‐glucose positron emission tomography pattern and prognostic predictors in patients with anti‐GABAB receptor encephalitis
Authors: Liu Xiao , Yu Tingting , Zhao Xiaobin , Li Gongfei , Lv Ruijuan , Ai Lin , Wang Qun 
Published: November 2021

AbstractAimsTo identify the metabolic pattern and prognostic predictors in anti‐gamma‐aminobutyric‐acid B (GABAB) receptor encephalitis using 18F‐fluorodeoxy‐glucose positron emission tomography (18F‐FDG‐PET).MethodsTwenty‐one patients diagnosed anti‐GABAB receptor encephalitis who underwent 18F‐FDG‐PET at first hospitalization were retrospectively reviewed. 18F‐FDG‐PET images were analyzed in comparison with controls. Further group comparisons of 18F‐FDG‐PET data were carried out between prognostic subgroups.Results18F‐FDG‐PET was abnormal in 81% patients with anti‐GABAB receptor encephalitis and was more sensitive than MRI (81% vs. 42.9%, p = 0.025). Alter limbic lobe glucose metabolism (mostly hypermetabolism) was observed in 14 patients (66.7%), of whom 10 (10/14, 71.4%) demonstrated hypermetabolism in the medial temporal lobe (MTL). Group analysis also confirmed MTL hypermetabolism in association with relative frontal and parietal hypometabolism was a general metabolic pattern. After a median follow‐up of 33 months, the group comparisons revealed that patients with poor outcome demonstrated increased metabolism in the MTL compared to those with good outcome.Conclusion18F‐FDG‐PET may be more sensitive than MRI in the early diagnosis of anti‐GABAB receptor encephalitis. MTL hypermetabolism was associated with relative frontal or parietal hypometabolism and may serve as a prognostic biomarker in anti‐GABAB receptor encephalitis.
Delivering the Diabetes Remission Clinical Trial (DiRECT) in primary care: Experiences of healthcare professionals
Authors: Rehackova Lucia , Taylor Roy , Lean Mike , Barnes Alison , McCombie Louise , Thom George , Brosnahan Naomi , Leslie Wilma S. , Sniehotta Falko F. 
Published: November 2021

AbstractObjectiveThe Diabetes Remission Clinical Trial (DiRECT) used a formula total diet replacement programme followed by structured weight loss maintenance to induce and sustain weight loss and remission of type 2 diabetes (T2D) in 36% of participants after 2 years. Nurses and dietitians delivering DiRECT in 22 primary care practices in Tyneside and Scotland provided behavioural support to participants. Participant experiences with DiRECT highlighted the key role of support by healthcare professionals (HCPs). We evaluated HCPs’ experiences with DiRECT.Research design and methodsHealthcare professionals delivering DiRECT were interviewed at 12 months, while general practices (GPs) were sent an implementation questionnaire. The interviews were analysed thematically. The questionnaires were analysed using frequencies and a narrative synthesis.ResultsHealthcare professionals representing 11 of 22 intervention practices were interviewed and 10 of 22 GPs completed questionnaires. HCPs’ initial concerns over perceived potential negative intervention effects, particularly withdrawing anti‐diabetes and anti‐hypertensive medications, were barriers to engagement. Trust of HCPs towards the research team and perceived credibility of the study facilitated engagement and adoption. Ongoing support by research dietitians was key to the management of participants. Involvement in DiRECT inspired more focus on behaviour modification in the treatment of other people living with T2D in routine practice.ConclusionsDiabetes Remission Clinical Trial was considered highly appropriate for the management of T2D in primary care when supported by trained dietitians. Addressing limitations, including varying training needs of HCPs may improve intervention scale‐up and tailoring to clinical contexts.
Antidepressants abuse in subjects with opioid use disorders: A 10‐year study in the French OPPIDUM program
Authors: Dumonceau Robinson Gravier , Soeiro Thomas , Lacroix Clémence , Giocanti Adeline , Frauger Élisabeth , Mezaache Salim , Micallef Joëlle 
Published: November 2021

AbstractAccumulating evidence shows that some antidepressants are abused for their psychostimulant effects, but the extent of antidepressants abuse is unknown in subjects with opioid use disorders (OUD). The objective of this work is to assess the prevalence of antidepressant abuse and its correlates in subjects with OUD. Subjects ≥18 year‐old in an opiate maintenance treatment (OMT) program who reported using an antidepressant were selected from the OPPIDUM program from 2011 to 2020. The outcome was antidepressant abuse. Antidepressant abusers were identified as subjects reporting at least one of the following behaviors: “drug abuse,” “concomitant use of alcohol,” “illegal obtaining,” and “dose higher than recommended in the Summary of Product Characteristics.” Among the 83 040 observations of subjects ≥18 year‐old in an OMT program included in the OPPIDUM program from 2011 to 2020, 2708 (3.3%) subjects reported using an antidepressant in monotherapy. Among them, there were 385 (14.2%) abusers. The proportion of abusers was the highest for amitriptyline (n = 31, 25.0%). In multivariate analysis, antidepressant abuse was positively associated with amitriptyline (OR 2.07, 95% CI [1.16, 3.73]; p = 0.015), unemployment (OR 1.52, 95% CI [1.16, 2.01]; p = 0.003), the use of intravenous route of administration (OR 1.77, 95% CI [1.12, 2.80]; p = 0.014), and the use of benzodiazepines (OR 1.53, 95% CI [1.21, 1.94]; p < 0.001). Clinicians should be aware of the risk of antidepressant abuse when prescribing in subjects with OUD, accounting for their heterogeneous pharmacological properties that may account for their abuse potential.
Glioma cells remotely promote erythropoiesis as a self‐expanding strategy of cancer stem cells
Authors: Aimaitijiang Alapati , Tabu Kouichi , Wang Wenqian , Nobuhisa Ikuo , Taga Tetsuya 
Published: November 2021

AbstractCancer stem cells are a promising target for cancer eradication due to their responsibility for therapy‐resistance and cancer recurrence. Previously, we have demonstrated that glioma stem cells (GSCs) recruit and induce the differentiation of bone marrow (BM) monocytes into tumor‐infiltrating macrophages, which phagocytose hemorrhaged erythrocytes and store GSC‐beneficial iron in mouse xenografts, suggesting a self‐expanding strategy of GSCs that exploits host hematopoiesis of myeloid cells. However, it remains unclear whether a self‐advantageous effect of GSCs also occurs on erythroid cells during glioma development. Here, we found that, in the primary cultures of mouse fetal liver proerythroblasts (proEs), conditioned media prepared from glioma cells including patient‐derived glioblastoma (GBM) cells significantly facilitated the differentiation of proEs into erythroblasts. Importantly, in‐vivo erythroid analysis in intracranially GSC‐transplanted mice showed an enhanced erythropoiesis in the BM. In addition, the sphere forming ability of patient‐derived GBM cells was significantly suppressed by hypoxia treatment and iron chelation, suggesting higher demands of GSCs for oxygen and iron, which may be supplied by GSCs‐ and their progeny‐induced erythrocyte production. Our findings provide a new insight into survival and expanding strategies of GSCs that systemically exploit host erythropoiesis.
Determining causes of death among individuals with haemophilia in Afghanistan
Authors: Mousavi Seyed Hamid , Arif Shamim , Madadi Shekiba , Mansouritorghabeh Hassan 
Published: November 2021

AbstractIntroductionHaemophilia is a well‐known bleeding disorder that affects people worldwide. The main therapeutic strategy is regular infusion of exogenous factor VIII to ensure an optimal haemostatic standard. Morbidity and mortality of individuals with haemophilia has decreased in developing countries due to improvement in early detection, advanced treatments, and comprehensive population outreach efforts. However, individuals with bleeding disorders in developing countries like Afghanistan do not have access to such therapeutic facilities.AimsThe goals of this study were to determine the causes of death and findings related to death among in individuals with bleeding disorders in Afghanistan.MethodsThis study conducted as a retrospective cross‐sectional study of 387 individuals with bleeding disorders (mainly haemophilia) in Afghanistan.ResultsAll registered individuals with bleeding disorders in Afghanistan were interviewed by telephone. Among the 387 individuals with bleeding disorders, there were 136 deaths. Most deaths occurred in individuals aged 1–15 years (66.2%). Intracranial haemorrhage was the leading cause of death in individuals with haemophilia A and B.ConclusionThese findings revealed that supply of coagulation factor concentrates, facilities for haemostasis diagnosis, and trained haematologists is inadequate in Afghanistan.
Imaging innate immunity*
Authors: Grüneboom Anika , Aust Oliver , Cibir Zülal , Weber Flora , Hermann Dirk M. , Gunzer Matthias 
Published: November 2021

AbstractInnate immunity is the first line of defense against infectious intruders and also plays a major role in the development of sterile inflammation. Direct microscopic imaging of the involved immune cells, especially neutrophil granulocytes, monocytes, and macrophages, has been performed since more than 150 years, and we still obtain novel insights on a frequent basis. Initially, intravital microscopy was limited to small‐sized animal species, which were often invertebrates. In this review, we will discuss recent results on the biology of neutrophils and macrophages that have been obtained using confocal and two‐photon microscopy of individual cells or subcellular structures as well as light‐sheet microscopy of entire organs. This includes the role of these cells in infection defense and sterile inflammation in mammalian disease models relevant for human patients. We discuss their protective but also disease‐enhancing activities during tumor growth and ischemia‐reperfusion damage of the heart and brain. Finally, we provide two visions, one experimental and one applied, how our knowledge on the function of innate immune cells might be further enhanced and also be used in novel ways for disease diagnostics in the future.
Relationship between nurses' use of verbal de‐escalation and mechanical restraint in acute inpatient mental health care: a retrospective study
Authors: Pérez‐Toribio Alonso , Moreno‐Poyato Antonio R. , Lluch‐Canut Teresa , Molina‐Martínez Laura , Bastidas‐Salvadó Anna , Puig‐Llobet Montserrat , Roldán‐Merino Juan F. 
Published: November 2021

ABSTRACTAlthough the use of verbal de‐escalation in nursing has been shown to be an effective tool for controlling agitation and avoiding mechanical restraint, there is scarce evidence supporting the use of de‐escalation by nurses and factors related to the patients who ultimately receive mechanical restraint. This retrospective study sought to examine the relationship between the use of verbal de‐escalation by nurses and the clinical profile of patients who had received mechanical restraint at an acute mental health unit. This study analysed the records of patients who had received mechanical restraint between the years 2012 and 2019. A bivariate analysis was initially performed, followed by multiple logistic regression analysis. A total of 493 episodes of restraint were recorded. Of these, in almost 40% of cases, no prior use of verbal de‐escalation was noted. The factors associated with the use of verbal de‐escalation by nurses were patients with a history of restraint episodes and patients who previously had been administered medication. Furthermore, episodes of mechanical restraint that occurred later during the admission were also associated with the use of de‐escalation. These findings confirm the relevance of early nurse interventions. Consequently, it is important to establish an adequate therapeutic relationship from the start of hospitalization to facilitate getting to know the patient and to enable the timely use of verbal de‐escalation, thus avoiding the use of mechanical restraint.
A review on competitive pricing in supply chain management problems: models, classification, and applications
Authors: Ziari Matineh , Ghomi‐Avili Morteza , Pishvaee Mir Saman , Jahani Hamed 
Published: November 2021

AbstractSupply chain management (SCM) deals with various strategic, tactical, and operational level decisions in which pricing is of utmost importance to decision makers. Most of the real‐life supply chain pricing problems consider competition as a crucial factor in order to expand the market share and tackle emerging competitors. Accordingly, competitive pricing in SCM has attracted great attention by practitioners and academicians in the last four decades. Now after 40 years, it seems necessary to systematically review and classify the previous studies and present the most appealing future research directions. This paper provides a comprehensive review of the state‐of‐the‐art published papers in scientific journals. Here, 166 papers published from 1983 to 2021 are reviewed and classified to introduce the major models and specific considerations in this field. After reviewing the selected competitive pricing models, some research insights and potential subjects for extending the literature are presented to illustrate the most appropriate and challenging future research directions.
Biosorption of lead ions from aqueous solution by Clostridium tyrobutyricum immobilized in macroporous Ca-alginate-lignin beads
Authors: Zheng Wenxiu , Zhao Qianru , Malkmes Matthew Jay , Gao Ge , He Jiaqi , Zheng Lei , Jiang Ling 
Published: November 2021

Abstract

Aims
The adsorption of lead ions from aqueous solution by macroporous Ca-alginate-lignin (MCAL) beads immobilized with Clostridium tyrobutyricum and free strains was evaluated.

Methods and Results
The effects of different factors including pH, adsorption time, adsorbent dosage and initial concentration of lead ions were explored. Different characterization methods were used to evaluate the adsorption process of lead ions. Meanwhile, the adsorption kinetics models and adsorption isotherm models were applied. The fitting results showed that the adsorption behaviour of C. tyrobutyricum immobilized in MCAL beads and free strains was better described by the pseudo-second-order kinetic model and the adsorption process followed the Langmuir isotherm model. The maximum biosorption of lead ions by C. tyrobutyricum immobilized in MCAL beads and free strains was 144.9 and 106.4 mg/g respectively.

Conclusions
The C. tyrobutyricum immobilized in MCAL beads proved to be practicable and had better adsorption effects on lead ions compared with the free strains.

Significance and Impact of the Study
The paper demonstrated a new insight and strategy for the effective treatment of lead ions from aqueous solutions by the novel function of C. tyrobutyricum.
Do all patients in the epilepsy monitoring unit experience the same level of comfort? A quantitative exploratory secondary analysis
Authors: Egger‐Rainer Andrea , Hettegger Sophie Martina , Feldner Raphael , Arnold Stephan , Bosselmann Christian , Hamer Hajo , Hengsberger Anna , Lang Johannes , Lorenzl Stefan , Lerche Holger , Noachtar Soheyl , Pataraia Ekaterina , Schulze‐Bonhage Andreas , Staack Anke Maren , Trinka Eugen , Unterberger Iris , Zimmermann Georg 
Published: November 2021

AbstractAimsTo find out which variables may be associated with comfort of patients in an epilepsy monitoring unit.DesignExploratory, quantitative study design.MethodsData were collected from October 2018 to November 2019 in Austria and Southern Germany. A total of 267 patients of 10 epilepsy centres completed the Epilepsy Monitoring Unit Comfort Questionnaire which is based on Kolcaba's General Comfort Questionnaire. Secondary data analysis were conducted by using descriptive statistics and an exploratory model building approach, including different linear regression models and several sensitivity analyses.ResultsTotal comfort scores ranged from 83 to 235 points. Gender, occupation and centre turned out to be possible influential variables. On average, women had a total comfort score 4.69 points higher than men, and retired persons 28.2 points higher than high school students ≥18 years. Comfort scores of younger patients were lower than those of older patients. However, age did not show a statistically significant effect. The same could be observed in marital status and educational levels.ConclusionWhen implementing comfort measures, nurses must be aware of variables which could influence the intervention negatively. Especially, high school students ≥18 years should be supported by epilepsy specialist nurses, in order to reduce uncertainty, anxiety and discomfort. But, since the identified variables account only for a small proportion of the inter‐individual variability in comfort scores, further studies are needed to find out additional relevant aspects and to examine centre‐specific effects more closely.ImpactNurses ensure patient comfort during a hospital stay. However, there are variables that may impair the effectiveness of the nursing measures. Our study showed that the experience of comfort was highly individual and could be explained by sociodemographic variables only to a limited extent. Nurses must be aware that additional factors, such as the situation in the individual setting, may be relevant.
Fair values and compensation contracting: Evidence from real estate firms
Authors: Henderson Darren 
Published: November 2021

AbstractI compare the compensation contracting relevance of fair values (FVs) and market values in the setting of UK real estate firms and find that FVs are weighted more heavily than market values. I further find that FV weighting is increasing in FV estimate reliability and signal strength, while market value weighting is decreasing in FV estimate reliability. FV accounting represents a key trend over the past several decades with International Financial Reporting Standards permitting FVs to a greater extent than many national standards. My study provides a counterpoint to existing studies that find FVs are not useful for contracting with executives (DeFond et al., 2020; Livne et al., 2011). Furthermore, I find that FV is used as a performance measure in an efficient way that is dependent on the signal‐to‐noise ratio of FV estimates.