bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faktor-faktor yang mempengaruhi minat berwirausaha mahasiswa Pendidikan Ekonomi angkatan 2016 STKIP PGRI Lumajang tahun akademik 2020/2021
Authors: Zunaedy Muhammad , Aisyah Siti , Ayuningtyas Triwilujeng 
Published: November 2021

Tujuan Penelitian untuk mengetahui analisis minat berwirausaha pendidikan ekonomi angkatan 2016 penelitian ini mengangkat permasalahan: Faktor-Faktor apa saja yang mempengaruhi minat berwirausaha mahasiswa pendidikan ekonomi angkatan 2016 di STKIP PGRI Lumajang?. Jenis penelitian yaitu penelitian kualitatif dengan pendekatan fenomenologi. Subjek penelitian yaitu mahasiswa pendidikan ekonomi di STKIP PGRI Lumajang dengan jumlah informan sebanyak 9 mahasiswa. teknik pengumpulan data yang digunakan yaitu dengan observasi dan wawancara kepada informan. Dengan teknik analisis data berupa pengumpulan data, reduksi data dan penarikan kesimpulan atau verifikasi. hasil penelitian dan pembahasan rata-rata minat sesuai dengan hasil observasi sekitar 93.86% yang menjawab dengan pilihan ya, dan berwirausaha sesuai dengan hasil observasi sekitar 95.97% yang menjawab dengan pilihan ya, Minat berwirausaha sesuai dengan hasil observasi sekitar 63.6% yang menjawab dengan pilihan ya, Kesimpulan dari penelitian ini bahwa minat berwirausaha dari mahasiswa angkatan 2016 cukup besar dan semakin tinggi minat berwirausaha mahasiswa maka semakin tinggi pula minat untuk menjadi wirausahawan.
Kata Kunci: Faktor-Faktor Minat Berwirausaha
The MAP4 Projection Domain Accelerates Hypoxia-Induced Mitophagy Disruption through LIR Motif in Cardiomyocytes
Authors: Huang Yuesheng , Feng Yanhai , Zhang Qiong , Li Lingfei , Zhang Junhui , Huang Yao , Lv Yanling , Jia Jiezhi , Zhang Dongxia , Luo Gaoxing , Hu Jiongyu 
Published: November 2021

Abstract
Previously, we and other investigators have demonstrated that phosphorylated microtubule-associated protein 4 (p-MAP4) impacts myocardial hypertrophy and ischemic heart failure. However, the detailed mechanism behind this remains under elucidated. Published studies have suggested that impaired mitophagy contributes to hypoxia-induced myocardial damage, hence the involvement of p-MAP4 in mitophagy in cardiomyocytes was investigated. The results herein revealed that there was increased degradation of mitochondria, accumulated mitophagosomes and disrupted autophagic flux in both neonatal and adult ones of MAP4-knockin (KI) mice. This indicated that p-MAP4 persistently degraded mitochondria through activating mitophagy. Next, Tom70 was found as the importer of p-MAP4 in the context of mitochondrial translocation. And, the LC3-interacting region (LIR) motif (47–50aa) caused p-MAP4-induced mitochondrial engulfment, and the ubiquitin-interacting motif (UIM) domain determined the characteristics of p-MAP4-induced mitophagosomes, which were structure and membrane potential-independent. Moreover, p-MAP4 enhanced hypoxia-induced mitophagic flux impairment, and p-MAP4 LIR (47–50aa) mutation decreased hypoxia-induced autophagy both in MAP4 knockout and wildtype cardiomyocytes. Overall, this study identified that p-MAP4 as a novel mediator and cargo receptor in mitophagy, and that the degradation of the MAP4 PJ domain as a promising therapeutic target for improving the cardiac function of hypoxia-related heart failure or cardiac remodelling.
Drivers of Drugs and Substance Use and Their Effects Among Young People in a Peri-Urban District of Ghana
Authors: Kasore Vida , Acheampong Enoch , Owusu-Ansah Frances Emily , Owusu Mark , Worlanyo Ampeh Unity , Gloria Winifred Apaaya Nyabamah 
Published: November 2021

Abstract
Background

Drugs and substance use-related effects have become a major issue globally. The energetic youth who contribute meaningfully to national development are the most affected population by this social menace. This study aimed to examine the knowledge and perception of the youth on drugs and substance use-related effects on the lives of drug users.
Methods

The study used a qualitative approach to explore the drivers of drugs and drugs and substance use among the youth in the Kwabre-East Municipality of the Ashanti Region of Ghana. The purposive technique was used to select 35 participants based on a set of inclusion and exclusion criteria. The data were gathered through focus group discussions and interviews in the Twi language and audio-recorded. Data were transcribed from Twi to English in a written form. The data were categorized into themes based on similarities and differences. Thematic analysis was used to analyze the data. The emerged themes have been presented as main findings, which are supported by quotations from the participants.
Results

The study identified that substances commonly used by the youth were alcohol, tramadol, gasoline product, glue, and marijuana. Again, it was found that peer influence, poor parental control, and loss of a job (poverty), perceived academic enhancement, and imitation of role models were factors that caused drugs and substance use among the youth. In addition, the following were identified in terms of the effects: mental illness, cardiovascular conditions, family exclusion, insecurity, and stigmatization.
Conclusion

The initiation and implementation of drug preventive interventions by relevant stakeholders are crucial in preventing the commencement of any undesirable behaviour among the youth as far as drugs and substance use is concerned.
Type II porous ionic liquid based on metal-organic cage that enables L-tryptophan identification
Authors: Zhang Zhuxiu , Yang Baolin , Zhang Bingjie , Cui Mifen , Tang Jihai , Qiao Xu 
Published: November 2021

Abstract
Porous liquids with chemical separation properties are quite well-studied in general, but there is only a handful of reports in the context of identification and separation of non-gaseous molecules. Herein, we report the first example of Type-II porous ionic liquid that exhibits exceptional selectivity towards L-tryptophan (L-Trp) over other aromatic amino acids and the first in which coordination cages promote this selectivity. A previously known class of anionic organic-inorganic hybrid doughnut-like cage (HD) has been readily dissolved in trihexyltetradecylphosphonium chloride (THTP_Cl). The resulting liquid, HD/THTP_Cl, is thereby composed of common components, facile to prepare, and exhibit room temperature fluidity. The permanent porosity are manifested by the high-pressure isotherm for CH4 and modeling studies. With evidence from time-dependent amino acid uptake, competitive extraction studies and molecular dynamic simulations, HD/THTP_Cl exhibit better selectivity towards L-Trp than existing solid state sorbents, and we attribute it to not only the intrinsic porosity of HD but also the host-guest interactions between HD and L-Trp. Specifically, each HD unit is binded with nearly 5 L-Trp molecules, which is higher than the L-Trp occupation in the structure unit of other benchmark metal-organic frameworks.
Valorisation of Fish Bones: Effects of Preservation by Formic Acid on AL-extractable calcium, Phosphorus, Magnesium, and Potassium
Authors: Løes Anne-Kristin , Ahlin Johan Petter , Ahuja Ishita , Krogstad Tore , Smevoll Ståle , Waag Hanne 
Published: November 2021

Abstract
Fishbones contain significant amounts of plant nutrients. Fish residues may be preserved by acidification to pH < 4, which may affect the extractability and plant availability of nutrients when applied as fertilisers. Grinded bone material from cod ( Gadus morhua ) heads was mixed with formic acid to investigate if acidification would increase the concentrations of ammonium acetate-lactate (AL)-extractable nutrients. Two degrees of fineness of fishbones (coarse 2-4 mm; fine < 0.71 mm) were compared at pH 3.0 and 4.0 plus a water control in a laboratory study over 55 days. Samples for extraction of AL-soluble P, Ca, Mg and K were taken on day 2, 15, 34 and 55. Whereas acidification clearly increased the concentrations of AL-extractable calcium (Ca-AL) and magnesium (Mg-AL), extractable phosphorus (P-AL) was only significantly increased in finely grinded bones at pH 3. After 34 days, 6% of the total content of P was extracted by AL in fine fishbones at pH 3. Without acidification about 1% of the P was extracted, possibly from phospholipids. This P-AL concentration was well above P-AL extracted from acidified coarse fishbones and from fine fishbones acidified to pH 4. With acidification, about 30% of total Ca and 10% of total Mg were extracted by AL, and the Ca-AL and Mg-AL concentrations were closely correlated. The reason for lower P-AL in coarse fishbones at pH 3 and 4, and fine fishbones at pH 4 than in water controls may be a precipitation of apatite from phospholipids and dissolved calcium.
Improving De Novo Molecular Design with Curriculum Learning
Authors: Guo Jeff , Fialková Vendy , Arango Juan Diego , Margreitter Christian , Janet Jon Paul , Papadopoulos Kostas , Engkvist Ola , Patronov Atanas 
Published: November 2021

Abstract
Reinforcement learning (RL) is a powerful paradigm that has gained popularity across multiple domains. However, applying RL may come at a cost of multiple interactions between the agent and the environment. This cost can be especially pronounced when the single feedback from the environment is slow or computationally expensive, causing extensive periods of nonproductivity. Curriculum learning (CL) provides a suitable alternative by arranging a sequence of tasks of increasing complexity with the aim of reducing the overall cost of learning. Here, we demonstrate the application of CL for drug discovery. We implement CL in the de novo design platform, REINVENT, and apply it on illustrative de novo molecular design problems of different complexity. The results show both accelerated learning and a positive impact on the quality of the output when compared to standard policy based RL. To our knowledge, this is the first application of CL for the purposes of de novo molecular design. The code is freely available at https://github.com/MolecularAI/Reinvent.
Synthesis and Evaluation of Cyclic Diamino Benzamide Based D3 Receptor Ligands
Authors: Blass Benjamin E. , Chen Peng-Jen , Taylor Michelle , Griffine Suzy A. , Gordon John C. , Luedtke Robert R. 
Published: November 2021

Abstract
Dopamine (1) is a key neurotransmitter whose impact on pharmacological processes is mediated by a family of dopamine receptors designated D1, D2, D3, D4, and D5. Various diseases and conditions such as schizophrenia, drug abuse, depression, restless leg syndrome, Parkinson’s disease (PD), and inflammatory diseases have been linked to aberrant D3 activity. Herein, we report a series of novel D3 ligands with improved solubility over our previous lead compound, MC25-41 (2).
Influence of Access To Finance On The Competitive Growth of SMEs in Lesotho.
Authors: Amadasun Donald Edes Osakpamwan , Mutezo Ashley T. 
Published: November 2021

Abstract
Background: Access to finance is identified as one of the biggest problems faced by Small and Medium-Sized Enterprises (SMEs) in most developing economies. Consequently, access to finance has been identified as a dominant constraint facing the SMEs sector in Lesotho. This paper established the factors of access to finance that influence the competitive growth of the SME sector in Lesotho. The factors addressed include financial information access, bank and business support services, the structure of banks and collateral requirements by the financial sector. Findings: The results from our analysis indicated that there is a relationship between independent variables of financial information access, Bank and business support service, the structure of banks and the collateral requirement by commercial banks and such influence SMEs capacity to attain competitive growth in Lesotho. In addition, the results indicated that Basotho entrepreneurs and managers see the predictors as critical factors of access to finance that constrained most enterprises access to needed credit from banks and such influence SMEs capacity to attain competitive growth in Lesotho. Conclusions: The study concludes that access to finance significantly affect the competitive growth of SMEs in Lesotho. Thus, this study suggests that several specific and harmonized financial policy actions are needed in the Lesotho financial market to identify enabling policy that ease enterprises access to adequate funding programs. These funding programs should target improved financial schemes that are coordinated, competitive and directed towards SMEs access to finance; harmonized credit policy which guarantees a win-win for SMEs loan applicants and the financial market operators.
Eosinophilic pneumonia induced by lettuce: A case report
Authors: Sekiya Reina , Nagano Tatsuya , Moriyama Tatsuya , Kawaguchi Aki , Fukui Takafumi , Mimura Chihiro , Kimura Yohei , Ohnishi Hisashi , Kotani Yoshikazu , Nishiura Yoshihiro 
Published: November 2021

Abstract
Background: Lettuce (Lactuca sativa) belongs to the Composite family and is a vegetable widely consumed globally. Although lettuce is extensively cultivated and consumed, lettuce-associated occupational allergy is rarely reported. Herein, we are reporting a case of eosinophilic pneumonia induced by lettuce for the first time.Case presentation: A 56-year-old female lettuce farmer was admitted to the hospital with a low-grade fever, worsening cough, and dyspnoea. A blood test revealed eosinophilia and a high serum IgE concentration. A chest X-ray taken on admission showed an infiltrative shadow in the upper lung field. Chest CT revealed patchy ground glass opacity on the upper lung field and thickening of the bronchial wall. The bronchoalveolar lavage fluid contained 8% eosinophils. The IgG-binding proteins that reacted with the patient’s sera were identified by immunoblot analysis. She was diagnosed as lettuce induced eosinophilic pneumonia and was treated with prednisolone, and her symptoms and radiological findings improved. Wearing a mask and reducing the amount of the crop improved her symptoms the following year.Conclusions: This is the first case report about lettuce-induced eosinophilic pneumonia which occurred in a lettuce farmer. The avoidance from antigen is quite useful in this patient.
Covid-19 and Crisis Management: The Necessity of Innovation in the Business Model of SMEs in Order to Recover and Develop Fast After the Corona Crisis
Authors: Mirzaye Sina 
Published: November 2021

Abstract
We know that SMEs are among the businesses most affected by the COVID-19 shutdown. The first theoretical and practical observations in SMEs show that innovation in business models can be a solution to successfully improve and cope with the COVID-19 crisis. In a way that arouses curiosity, some SMEs have already begun to successfully change and reconciling their business models. This paper provides a qualitative analysis of six local SMEs in Iran to explore how SMEs adapt their business models to crisis. We collected interview data from managers with one of their middle managers for each case, which we triangle for analysis with secondary data. According to the results, BMI could be used during and after a crisis to generate new income, maintain and exit pre-crisis conditions, and develop.
An Indirect Method for the Quantitative Identification of Unstable Rock
Authors: DU YAN , Xie Mowen 
Published: November 2021

Abstract
Under the influence of continuous external factors (rainfall, earthquake, construction, etc.), the slope rock mass in a stable state gradually transited to an unstable rock, and then the unstable rock collapsed. However, a safety factor can identify the occurrence of failure but cannot identify the transition of stable rock to unstable rock; thus, it cannot realise the quantitative identification of unstable rocks. In this study, safety factor of adhesion (SFA ) and a relatively objective analysis method are proposed to effectively identify unstable rocks. SFA can be calculated by natural vibration frequency and applied as a mechanical index to judge unstable rock. When SFA is less than 1, the rock is defined as an unstable rock. Compared with the traditional method, the new method has the merits of simple operation, low cost and higher efficiency, and provides a relatively complete quantitative evaluation index and judgment criteria for quantitative identification of unstable rocks for engineers who are engaged in early warning and prevention of rock collapse.
Mental Well-Being During Stages of COVID-19 Lockdown Among Pregnant Women And New Mothers
Authors: Overbeck Gritt , Rasmussen Ida Scheel , Siersma Volkert , Kragstrup Jakob , Ertmann Ruth Kirk , Wilson Philip 
Published: November 2021

Abstract
Background: Pregnancy and early motherhood are sensitive times where epidemic disease outbreaks can affect mental health negatively. Countries and health care systems handled the pandemic and lockdowns differently and knowledge about how the COVID-19 pandemic affected the mental well-being of pregnant women and new mothers is limited and points in different directions. Aim. to investigate symptoms of anxiety and depression in a population of pregnant women and new mothers in various stages of infection pressure and lock down during the first 15 months of the COVID-19 pandemic in Denmark. Methods: The study population was nested an inception cohort of women recruited in their first trimester of pregnancy. Data about mental health of the woman was obtained in relation to pregnancy and child development (first trimester, 8 weeks postpartum and 5 months postpartum), and data were analysed cross-sectionally according to calendar time (periods defined by infection rate and lock-down during the COVID-19 epidemic).Results: No differences in reported levels of depressive symptoms between the six examined time periods of the pandemic were observed. Specifically, symptoms remained unchanged after the first lock-down. No major changes in anxiety symptoms were observed in relation to increased infection pressure or lockdowns, but a small increase was observed during the second lockdown in women 8 weeks postpartum. Conclusion: No clear change in mood among pregnant women was seen between during the stages of Covid-19 pandemic in Denmark.
Therapeutic Nucleus-Access BNCT Drug Combined CD47-Targeting Gene Editing in Glioblastoma
Authors: Chen Jiejian , Dai Qi , Yang QiYao , Bao Xiaoyan , Zhou Yi , Zhong Haiqing , Wu Linjie , Wang Tiantian , Zhang Zhicheng , Lu Yiying , Zhang Zhentao , Lin Mengting , Han Min , Wei Qichun 
Published: November 2021

Abstract
Glioblastoma is the most common brain primary malignant tumor with the highest mortality. Boron neutron capture therapy (BNCT) can efficiently kill cancer cells on the cellular scale, with high accuracy, short course and low side-effects, which is regarded as the most promising therapy for malignant brain tumors like glioma. As the keypoint of BNCT, all boron delivery agents currently in clinical use are beset by insufficient tumor uptake, especially in the tumor nucleus, which limits the clinical application of BNCT. In this study, nuclear targeting of boron is achieved by DOX-CB, consisting of doxorubicin (DOX) andcarborane (CB) utilizing the nuclear translocation property of DOX. The nucleus of GL261 cells takes up almost three times the concentration of boron required for BNCT. To further kill glioma and inhibit recurrence, a new multifunctional nanoliposome delivery system DOX-CB@lipo-pDNA-iRGDis constructed. It combines DOX-CB with immunotherapy strategy of blocking macrophage immune checkpoint pathway CD47-SIRPα by CRISPR-Cas9 system, coupling BNCT with immunotherapy simultaneously. Compared with clinical drug Borocaptate Sodium (BSH), DOX-CB@lipo-pDNA-iRGD significantly enhances the survival rate of tumor-bearing mice, reduces tumor stemness, and improves the prognosis. The excellent curative effect of this nanoliposome delivery system provides an insight into the combined treatment of BNCT.
Silencing lncRNA CDKN2B-AS1 Alleviates Childhood Asthma Progression Through Inhibiting ZFP36 Promoter Methylation and Promoting NR4A1 Expression
Authors: Chen Zhixin , Fan Nuandong , Shen Guangsheng , Yang Jing 
Published: November 2021

Abstract
LncRNA cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) was found to be upregulated in plasma of patients with bronchial asthma. This study aimed to explore the roles and mechanisms of CDKN2B-AS1 in childhood asthma. We found that CDKN2B-AS1 was upregulated and zinc finger protein 36 (ZFP36) mRNA was downregulated in blood samples of children with asthma compared with healthy controls as measured by RT-qPCR. Human bronchial epithelial cell line BEAS-2B was treated with LPS to induce inflammation model. Small interfering RNA against CDKN2B-AS1 (si-CDKN2B-AS1) was transfected into LPS-treated BEAS-2B cells, and we observed that CDKN2B-AS1 silencing increased cell viability and inhibited apoptosis and inflammation cytokine levels in LPS-treated BEAS-2B cells. Methylation-specific PCR, ChIP and RIP assays indicated that CDKN2B-AS1 inhibited ZFP36 expression by recruiting DNMT1 to promote ZFP36 promoter methylation. Co-IP assay verified the interaction between ZFP36 and nuclear receptor subfamily 4 group A member 1 (NR4A1) proteins. Then rescue experiments revealed that ZFP36 knockdown reversed the effects of CDKN2B-AS1 silencing on BEAS-2B cell functions. ZFP36 overexpression facilitated apoptosis, inflammation and p-p65 expression in BEAS-2B cells, while NR4A1 knockdown reversed these effects. Additionally, CDKN2B-AS1 silencing alleviated airway hyperresponsiveness and inflammation in ovalbumin (OVA)-induced asthma mice. In conclusion, silencing lncRNA CDKN2B-AS1 enhances BEAS-2B cell viability, reduces apoptosis and inflammation in vitro and alleviated asthma symptoms in OVA-induced asthma mice in vivo through inhibiting ZFP36 promoter methylation and NR4A1-mediated NF-κB signaling pathway.