bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative Analysis of Metabolomics and Transcriptomics Data Identifies Prognostic Biomarkers Associated With Oral Squamous Cell Carcinoma
Authors: Zuo Lihua , Chen Zhuo , Chen Lihuang , Kang Jian , Shi Yingying , Liu Liwei , Zhang Shuhua , Jia Qingquan , Huang Yi , Sun Zhi 
Published: October 2021

BackgroundOral squamous cell carcinoma (OSCC) is the most malignant neoplasm in oral cancer. There is growing evidence that its progression involves altered metabolism. The current method of evaluating prognosis is very limited, and metabolomics may provide a new approach for quantitative evaluation. The aim of the study is to evaluate the use of metabolomics as prognostic markers for patients with OSCC.MethodsAn analytical platform, Ultra-Performance Liquid Chromatography-Quadrupole/Orbitrap High Resolution Mass Spectrometry (UHPLC-Q-Orbitrap HRMS), was used to acquire the serum fingerprinting profiles from a total of 103 patients of OSCC before and after the operation. In total, 103 OSCC patients were assigned to either a training set (n = 73) or a test set (n = 30). The potential biomarkers and the changes of serum metabolites were profiled and correlated with the clinicopathological parameters and survival of the patients by statistical analysis. To further verify our results, we linked them to gene expression using data from the Kyoto Encyclopedia of Genes and Genomes (KEGG).ResultsIn total, 14 differential metabolites and five disturbed pathways were identified between the preoperative group and postoperative group. Succinic acid change-low, hypoxanthine change-high tumor grade, and tumor stage indicated a trend towards improved recurrence-free survival (RFS), whether in a training set or a test set. In addition, succinic acid change-low, hypoxanthine change-high, and tumor grade provided the highest predictive accuracy of the patients with OSCC. KEGG enrichment analysis showed that the imbalance in the amino acid and purine metabolic pathway may affect the prognosis of OSCC.ConclusionsThe changes of metabolites before and after operation may be related to the prognosis of OSCC patients. UHPLC-Q-Orbitrap HRMS serum metabolomics analysis could be used to further stratify the prognosis of patients with OSCC. These results can better understand the mechanisms related to early recurrence and help develop more effective therapeutic targets.
Radiomic Features of Multi-ROI and Multi-Phase MRI for the Prediction of Microvascular Invasion in Solitary Hepatocellular Carcinoma
Authors: Yang Yan , Fan WeiJie , Gu Tao , Yu Li , Chen HaiLing , Lv YangFan , Liu Huan , Wang GuangXian , Zhang Dong 
Published: October 2021

ObjectivesTo develop and validate an MR radiomics-based nomogram to predict the presence of MVI in patients with solitary HCC and further evaluate the performance of predictors for MVI in subgroups (HCC ≤ 3 cm and &gt; 3 cm).Materials and MethodsBetween May 2015 and October 2020, 201 patients with solitary HCC were analysed. Radiomic features were extracted from precontrast T1WI, arterial phase, portal venous phase, delayed phase and hepatobiliary phase images in regions of the intratumoral, peritumoral and their combining areas. The mRMR and LASSO algorithms were used to select radiomic features related to MVI. Clinicoradiological factors were selected by using backward stepwise regression with AIC. A nomogram was developed by incorporating the clinicoradiological factors and radiomics signature. In addition, the radiomic features and clinicoradiological factors related to MVI were separately evaluated in the subgroups (HCC ≤ 3 cm and &gt; 3 cm).ResultsHistopathological examinations confirmed MVI in 111 of the 201 patients (55.22%). The radiomics signature showed a favourable discriminatory ability for MVI in the training set (AUC, 0.896) and validation set (AUC, 0.788). The nomogram incorporating peritumoral enhancement, tumour growth type and radiomics signature showed good discrimination in the training (AUC, 0.932) and validation sets (AUC, 0.917) and achieved well-fitted calibration curves. Subgroup analysis showed that tumour growth type was a predictor for MVI in the HCC ≤ 3 cm cohort and peritumoral enhancement in the HCC &gt; 3 cm cohort; radiomic features related to MVI varied between the HCC ≤ 3 cm and HCC &gt; 3 cm cohort. The performance of the radiomics signature improved noticeably in both the HCC ≤ 3 cm (AUC, 0.953) and HCC &gt; 3 cm cohorts (AUC, 0.993) compared to the original training set.ConclusionsThe preoperative nomogram integrating clinicoradiological risk factors and the MR radiomics signature showed favourable predictive efficiency for predicting MVI in patients with solitary HCC. The clinicoradiological factors and radiomic features related to MVI varied between subgroups (HCC ≤ 3 cm and &gt; 3 cm). The performance of radiomics signature for MVI prediction was improved in both the subgroups.
Correlation of Early Nutritional Supply and Development of Bronchopulmonary Dysplasia in Preterm Infants <1,000 g
Authors: Thiess Theresa , Lauer Tina , Woesler Annika , Neusius Janine , Stehle Sandro , Zimmer Klaus-Peter , Eckert Gunter Peter , Ehrhardt Harald 
Published: October 2021

Background: Bronchopulmonary dysplasia (BPD) has multifactorial origins and is characterized by distorted physiological lung development. The impact of nutrition on the incidence of BPD is less studied so far.Methods: A retrospective single center analysis was performed on n = 207 preterm infants &lt;1,000 g and &lt;32 weeks of gestation without severe gastrointestinal complications to assess the impact of variations in nutritional supply during the first 2 weeks of life on the pulmonary outcome. Infants were grouped into no/mild and moderate/severe BPD to separate minor and major limitations in lung function.Results: After risk adjustment for gestational age, birth weight, sex, multiples, and antenatal steroids, a reduced total caloric intake and carbohydrate supply as the dominant energy source during the first 2 weeks of life prevailed statistically significant in infants developing moderate/severe BPD (p &lt; 0.05). Enteral nutritional supply was increased at a slower rate with prolonged need for parenteral nutrition in the moderate/severe BPD group while breast milk provision and objective criteria of feeding intolerance were equally distributed in both groups.Conclusion: Early high caloric intake is correlated with a better pulmonary outcome in preterm infants &lt;1,000 g. Our results are in line with the known strong impact of nutrient supply on somatic growth and psychomotor development. Our data encourage paying special attention to further decipher the ideal nutritional requirements for unrestricted lung development and promoting progressive enteral nutrition in the absence of objective criteria of feeding intolerance.
Freehand Stereotactic Image-Guidance Tailored to Neurotologic Surgery
Authors: Schneider Daniel , Anschuetz Lukas , Mueller Fabian , Hermann Jan , O'Toole Bom Braga Gabriela , Wagner Franca , Weder Stefan , Mantokoudis Georgios , Weber Stefan , Caversaccio Marco 
Published: October 2021

Hypothesis: The use of freehand stereotactic image-guidance with a target registration error (TRE) of μTRE + 3σTRE &lt; 0.5 mm for navigating surgical instruments during neurotologic surgery is safe and useful.Background: Neurotologic microsurgery requires work at the limits of human visual and tactile capabilities. Anatomy localization comes at the expense of invasiveness caused by exposing structures and using them as orientation landmarks. In the absence of more-precise and less-invasive anatomy localization alternatives, surgery poses considerable risks of iatrogenic injury and sub-optimal treatment. There exists an unmet clinical need for an accurate, precise, and minimally-invasive means for anatomy localization and instrument navigation during neurotologic surgery. Freehand stereotactic image-guidance constitutes a solution to this. While the technology is routinely used in medical fields such as neurosurgery and rhinology, to date, it is not used for neurotologic surgery due to insufficient accuracy of clinically available systems.Materials and Methods: A freehand stereotactic image-guidance system tailored to the needs of neurotologic surgery–most importantly sub-half-millimeter accuracy–was developed. Its TRE was assessed preclinically using a task-specific phantom. A pilot clinical trial targeting N = 20 study participants was conducted (ClinicalTrials.gov ID: NCT03852329) to validate the accuracy and usefulness of the developed system. Clinically, objective assessment of the TRE is impossible because establishing a sufficiently accurate ground-truth is impossible. A method was used to validate accuracy and usefulness based on intersubjectivity assessment of surgeon ratings of corresponding image-pairs from the microscope/endoscope and the image-guidance system.Results: During the preclinical accuracy assessment the TRE was measured as 0.120 ± 0.05 mm (max: 0.27 mm, μTRE + 3σTRE = 0.27 mm, N = 310). Due to the COVID-19 pandemic, the study was terminated early after N = 3 participants. During an endoscopic cholesteatoma removal, a microscopic facial nerve schwannoma removal, and a microscopic revision cochlear implantation, N = 75 accuracy and usefulness ratings were collected from five surgeons each grading 15 image-pairs. On a scale from 1 (worst rating) to 5 (best rating), the median (interquartile range) accuracy and usefulness ratings were assessed as 5 (4–5) and 4 (4–5) respectively.Conclusion: Navigating surgery in the tympanomastoid compartment and potentially in the lateral skull base with sufficiently accurate freehand stereotactic image-guidance (μTRE + 3σTRE &lt; 0.5 mm) is feasible, safe, and useful.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT03852329.
1H NMR Study of the HCa2Nb3O10 Photocatalyst with Different Hydration Levels
Authors: Shelyapina Marina G. , Silyukov Oleg I. , Andronova Elizaveta A. , Nefedov Denis Y. , Antonenko Anastasiia O. , Missyul Alexander , Kurnosenko Sergei A. , Zvereva Irina A. 
Published: October 2021

The photocatalytic activity of layered perovskite-like oxides in water splitting reaction is dependent on the hydration level and species located in the interlayer slab: simple or complex cations as well as hydrogen-bonded or non-hydrogen-bonded H2O. To study proton localization and dynamics in the HCa2Nb3O10·yH2O photocatalyst with different hydration levels (hydrated—α-form, dehydrated—γ-form, and intermediate—β-form), complementary Nuclear Magnetic Resonance (NMR) techniques were applied. 1H Magic Angle Spinning NMR evidences the presence of different proton containing species in the interlayer slab depending on the hydration level. For α-form, HCa2Nb3O10·1.6H2O, 1H MAS NMR spectra reveal H3O+. Its molecular motion parameters were determined from 1H spin-lattice relaxation time in the rotating frame (T1ρ) using the Kohlrausch-Williams-Watts (KWW) correlation function with stretching exponent β = 0.28: Ea=0.2102 eV, τ0=9.01 × 10−12 s. For the β-form, HCa2Nb3O10·0.8H2O, the only 1H NMR line is the result of an exchange between lattice and non-hydrogen-bonded water protons. T1ρ(1/T) indicates the presence of two characteristic points (224 and 176 K), at which proton dynamics change. The γ-form, HCa2Nb3O10·0.1H2O, contains bulk water and interlayer H+ in regular sites. 1H NMR spectra suggest two inequivalent cation positions. The parameters of the proton motion, found within the KWW model, are as follows: Ea=0.2178 eV, τ0=8.29 × 10−10 s.
Mudando vidas invisibilizadas: percepções de participantes sobre os impactos de um projeto de inclusão e letramento digital
Authors: Rodrigues Alessandra , Oliveira Ana Carolina Sales , Nunes Ivan Venâncio de Oliveira , Silva Jéssica Dessihé Canuto Flora da 
Published: October 2021

Considerando a cultura digital em que estamos hoje inseridos e a necessidade de usos críticos e criativos das tecnologias nos mais diversos contextos sociais, nas relações de trabalho, nas escolas etc., este estudo analisa as percepções de sujeitos acerca dos impactos de sua participação em um projeto de extensão universitária cujo objetivo é promover a inclusão digital e social e desenvolver letramentos digitais de sujeitos com nível fundamental e médio de escolaridade. Os dados foram coletados ao longo de 2018 por meio de registros escritos dos participantes. Os depoimentos indicam que os sujeitos passaram a ter melhores condições de acesso à informação e à cultura, além de ampliarem os usos das Tecnologias Digitais de Informação e Comunicação (TDIC) no cotidiano e iniciarem um processo de empoderamento. http://dx.doi.org/10.35700/ca.2020.ano7n13.p16-23.2869
The Effect of Beans Position of the Fruit and Liquid Organic Fertilizer on the Cocoa Seedlings
Authors: Syahputra Billy Yudha , Razali Razali , Berliana Yunida , Nadhira Ahmad 
Published: October 2021

Introduction: This study was aimed to examine the effect of beans positions of the fruit and Liquid Organic Fertilizer (LOF) on the growth of the cocoa seedlings (Theobroma cacao ) in early nurseries.
Materials and Methods: This study was conducted at the agricultural experiment land, Universitas Tjut Nyak Dhien, Medan Helvetia District, Medan City from April to June 2020. This study used a Randomized Block Design (RBD) within two factors. The first factor was beans position of the fruit (B0= peduncular, B1= median, B2= apical). The second factor was LOF application (D0= un-treated, D1= 3 ml.l-1, D2= 5 ml.l-1). The variables including radicle length, seedlings height, number of leaves, leaf area, stem diameter, and root fresh weight were then processed using ANOVA and BNT at the rate of 5%.
Results: The beans position of the cocoa fruit was an insignificant effect on all parameters of seedlings. LOF application was significant on seedlings height at 4, 6, and 8 weeks after planting (WAP) and also the number of leaves at 8 WAP, but it had an insignificant effect on radicle length, leaf area, stem diameter, and root fresh weight. The interaction of beans position of the fruit and LOF application on the vegetative growth of cocoa seedlings in the early nursery also did insignificant in all parameters of this study.
Vegetation Analysis of Invasive Plants in Batang Gadis National Park Resort 7 Sopotinjak
Authors: Diana Putri , Febriani Husnarika , Hutasuhut Melfa Aisyah 
Published: October 2021

Introduction: The purpose of this study was to determine the type and diversity of invasive plants in Batang Gadis National Park (BGNP).
Materials and Methods: This study was conducted in Batang Gadis National Park Resort 7 Sopotinjak, Mandailing Natal from February until April 2021. This study using the quadratic method by making transects and each transect is divided into 8 plots. Laying plots by purposive sampling as many as 8 plots.
Results: BGNP Resort 7 had the invasive plants consisted of 12 families, 20 species and 1287 individuals. The highest species was found in Melastoma malabathricum L (230) and the highest important value index was found in Strobilanthes reptans (35.82%), while the species with the lowest significance index was Ageratum conyzoides (3.40%). The invasive plant diversity index was categorized as moderate (H'= 2.43).
قدرة حفظ القرآن الكريم وعلاقتها في سهولة تعلم اللغة العربية لدى طالبات المعهد العالي للدراسات الإسلامية واللغة العربية
Authors: Rahmayani Rahmayani , Arsyad Aisyah , Hamka Hamka 
Published: October 2021

This thesis discusses the relationship between the ability of memorizing the Al-Qur'an al-kariim and the easeness of Arabic learning for female students at STIBA Makassar. The main objectives of this research were threefolds: 1. To understand the female students’ ability in memorizing the Al-Qur'an al-kariim at STIBA Makassar, 2. To understand the processes of the Arabic learning and the Al-Qur'an al-kariim memorization activities of female students at STIBA Makassar, 3. To investigate the relationship between the Al-Qur'an al-kariim memorization ability and the easiness of Arabic learning for female students at STIBA Makassar. The researcher completed this study by using a qualitative descriptive method with a semi-quantitative approach. The data collection methods used in this research were personal interviews and accurate observations on the students’ learning process. The data of students’ academic assessments who were successful in one semester were collected and analysed. The quantitative data were also collected in this research from the answers of students through compatibility approach. From this research, it was apparent that the methods used by the teachers and students in memorizing the Al-Qur'an al-kariim was considered to be very good. In terms of the relationship between the Al-Qur'an al-kariim memorization and Arabic learning, 100% of teachers and 97.9% of female students at STIBA Makassar were in agreement that there is a strong and close relationship between the Al-Qur'an al-kariim memorization and Arabic learning. In this case, the Al-Qur'an al-kariim memorization could assist students to understand the Arabic language and context and to pronounce the Arabic words and letters contained in the verses of the Al-Qur'an al-kariim. Besides, the non-Arabic Al-Qur'an al-kariim memorizers are able to learn Arabic easily because by memorizing the Al-Qur'an al-kariim, a memorizer applies and practices various aspects that could better their Arabic such as the four language skills, the Arabic elements, and the contexts of religious lessons and understandings.
KESANTUNAN PRAGMATIK RIDWAN KAMIL DALAM SOSIALISASI VAKSINASI COVID-19 DI MEDIA SOSIAL
Authors: Herliana Monika , Destyanisa Tazkiyah  
Published: October 2021

The discussion of this research is about the types of speech acts in the socialization of Covid-19 vaccination on social media which are closely related to linguistic pragmatics. The type of speech act from a pragmatic point of view is language behavior that has rules that agreed by the speaker and the speech partner. Since the beginning of the 2020 period until the beginning of 2021, Ridwan Kamil as the regional head and public figure has participated in the socialization of the Covid-19 vaccination. Social media is an effective forum for disseminating information, notification, or invitations for everyone to support the success of Covid-19 vaccination socialization. Even Ridwan Kamil used social media for these activities. The purpose of this study is to describe Ridwan Kamil's speech forms that adhere to Leech's maxims of politeness principles, as well as the function of politeness in Searle's (1969) language. The method of data collection is observing with the note-taking technique. The data analysis method uses data triangulation. The findings of this study indicate that from 155 speech data of Ridwan Kamil in the socialization of Covid-19 vaccination, six maxims of politeness principles are met, namely the Maxim of Wisdom, Maxim of Generosity, Maxim of Praise, Maxim of Humility, Maxim of Approval and Maxim of Sympathy; and has five speech functions Representative, Directive function, Commissive function, Expressive function and Declarative function.
Abstrak
Pembahasan penelitian ini tentang jenis tindak tutur dalam sosialisasi vaksinasi Covid-19 di media sosial yang berhubungan erat dengan pragmatik linguistik. Jenis tindak tutur dari sudut pandang pragmatik merupakan tingkah laku berbahasa yang memiliki aturan yang disepakati penutur dan mitra tutur. Sejak awal periode tahun 2020 hingga awal tahun 2021 ini, Ridwan Kamil sebagai kepala daerah dan figur publik turut serta dalam sosialisasi vaksinasi Covid-19. Penggunaan media sosial menjadi wadah yang efektif untuk menyebarkan informasi, himbauan, ataupun ajakan untuk turut menyukseskan sosialisasi vaksinasi Covid-19. Pun dengan Ridwan Kamil yang menggunakan media sosial untuk kegiatan tersebut. Tujuan dari penelitian ini mendeskripsikan bentuk tuturan Ridwan Kamil yang mematuhi maksim prinsip kesantunan Leech, serta fungsi kesantunan berbahasa Searle (1969). Metode yang digunakan dalam pengumpulan data yakni metode simak dengan teknik catat. Metode analisis data menggunakan triangulasi data. Temuan penelitian ini menunjukkan bahwa dari 155 data tuturan Ridwan kamil dalam sosialisasi vaksinasi Covid-19 memenuhi enam maksim prinsip kesantunan yaitu Maksim Kebijaksanaan, Maksim Kedermawanan, Maksim Pujian, Maksim Kerendahan Hati, Maksim Persetujuan dan Maksim Kesimpatian; dan memiliki lima fungsi tuturan Representatif, fungsi Direktif, fungsi Komisif, fungsi Ekspresif dan fungsi Deklaratif.
MODEL STRATEGI PEMASARAN BERBASIS DIGITAL PADA KOPERASI SIMPAN PINJAM (KONSEP PADA KOPERASI MUGI LESTARI)
Authors: Citra Savitri  , Mumun Maemunah  
Published: October 2021

Perubahan perilaku konsumen pada masa pandemi membawa dampak pada perkembangan bisnis saat ini. Koperasi merupakan salah satu unit usaha yang berdampak pada masa pandemi. Salah satu strategi yang harus dilakukan oleh setiap bisnis adalah meningkatkan atau merubah pola pemasaran dari basis offline menjadi online agar dapat bersaing. Model konsep strategi pemasaran berbasis digital diharapkan mampu memberikan peluang untuk tetap bertahan di dunia perkoperasian. Koperasi Simpan Pinjam Mugi Lestari merupakan salah satu koperasi yang secara langsung berdampak dari masa pandemi. Edukasi tentang peran penting pengembangan pemasaran berbasis digital melalui metode ceramah dan diskusi diberikan sebagai upaya intuk bersaing dan meningkatkan kemampuan dalam mengembangkan bisnis KSP serta upaya untuk melakukan transformasi transformasi dari era konvensional menuju era digital. Hasil yang diperoleh dari kegiatan ini diharapkan dapat memberikan sumbangan bagi KSP Mugi Lestari melalui peningkatan usaha dengan menerapkan strategi pemasaran berbasis digital yang tepat.
Kata Kunci : Strategi pemasaran, Digital,Koperasi simpan pinjam.
The Atacama Cosmology Telescope: Microwave Intensity and Polarization Maps of the Galactic Center
Authors: Guan Yilun , Clark Susan E. , Hensley Brandon S. , Gallardo Patricio A. , Naess Sigurd , Duell Cody J. , Aiola Simone , Atkins Zachary , Calabrese Erminia , Choi Steve K. , Cothard Nicholas F. , Devlin Mark , Duivenvoorden Adriaan J. , Dunkley Jo , Dünner Rolando , Ferraro Simone , Hasselfield Matthew , Hughes John P. , Koopman Brian J. , Kosowsky Arthur B. , Madhavacheril Mathew S. , McMahon Jeff , Nati Federico , Niemack Michael D. , Page Lyman A. , Salatino Maria , Schaan Emmanuel , Sehgal Neelima , Sifón Cristóbal , Staggs Suzanne , Vavagiakis Eve M. , Wollack Edward J. , Xu Zhilei 
Published: October 2021

Abstract
We present arcminute-resolution intensity and polarization maps of the Galactic center made with the Atacama Cosmology Telescope. The maps cover a 32 deg2 field at 98, 150, and 224 GHz with ∣l∣ ≤ 4°, ∣b∣ ≤ 2°. We combine these data with Planck observations at similar frequencies to create coadded maps with increased sensitivity at large angular scales. With the coadded maps, we are able to resolve many known features of the Central Molecular Zone (CMZ) in both total intensity and polarization. We map the orientation of the plane-of-sky component of the Galactic magnetic field inferred from the polarization angle in the CMZ, finding significant changes in morphology in the three frequency bands as the underlying dominant emission mechanism changes from synchrotron to dust emission. Selected Galactic center sources, including Sgr A*, the Brick molecular cloud (G0.253+0.016), the Mouse pulsar wind nebula (G359.23-0.82), and the Tornado supernova remnant candidate (G357.7-0.1), are examined in detail. These data illustrate the potential for leveraging ground-based cosmic microwave background polarization experiments for Galactic science.