bluuebunny/crossref_metadata_2025_split huggingface dataset:
MYOCARDIAL INFARCTION IN YOUNG MEN, FEATURES OF CLINICAL COURSE AND STATE OF ERECTILE FUNCTION
Authors: Makukha Yu.M. , Kravchenko A.M. , Andrieiev Ie.V. , Aleksieienko O.O. 
Published: July 2021

Aim of the study is to determine the features of the clinical course and study the state of erectile function in young men who have suffered MI.
112 male patients of Caucasian race of the Ukrainian population under the age of 50 (mean 43.21±2.8 years) who have had MI were examined.
Clinical and anamnestic data indicate the similarity of young men who have suffered MI with their peers. Yes, there are no significant differences in the percentage of smokers, burdened family history. Analysis of erectile dysfunction, according to the IIEF-5 questionnaire, indicates the presence of problems in young men who have suffered MI.
All examined patients were admitted to the hospital within 12 hours from the first symptoms of MI, which allowed to perform urgent coronary angiography with subsequent endovascular intervention - stenting. According to the cardiac ventriculography, about half of the patients (50 - 44.6%) had a three-vessel disease despite the young age.
One third of patients received as a beta-blocker the new class of drug of the 3rd generation - nebivalol (37 patients - 33.0%), which is important for young patients, as this drug has no adverse effects on erectile function in men. 44 (39.3%) received bisoprolol, a more common long-term beta-blocker. 31 patients had contraindications to beta-blockers.

Conclusions.

Myocardial infarction in young men was characterized by a high frequency of anginal form of the clinical course, multivessel disease of the coronary arteries, lipid profile disorders, a high proportion of patients with erectile dysfunction.
Erectile dysfunction in young men is an early marker of coronary heart disease. All men with ED should undergo a thorough cardiac examination to determine lipid profile and testosterone levels.
In patients with coronary heart disease, the symptoms of ED should be actively identified, initiate targeted lifestyle changes to reduce risks, as well as taken into account when choosing drugs for medical treatment.
COMPREHENSIVE ASSESSMENT OF COMBORIDITY IN CLINICAL PRACTICE: METHODICAL APPROACHES AND PRACTICAL USE
Authors: Moroz G.Z. , Hidzynska I.M. , Lasytsia T.S. 
Published: July 2021

Aim: to evaluate current approaches to the assessment of comorbidity in clinical practice and determine the prevalence of comorbidities in patients with coronary artery disease (CAD) who underwent coronary artery stenting.
Material and methods. We performed a retrospective analysis of data from electronic medical records of 150 CAD patients below 75 yrs having undergone myocardial revascularization via percutaneous coronary intervention (coronary artery stenting). All of them were under the monitoring of the cardiologists of the State Institution of Science «Research and Practical Center of Preventive and Clinical Medicine” State Administrative Department. Comorbidity assessment was performed via diseases count; we have dealt only with diseases that are included in the Charlson Comorbidity Index (ССІ) and Combined Age Charlson Comorbidity Index (СА-ССІ) calculation proceeding. We used statistical software programs (Statistica v. 6.0) and Microsoft Excel 2007 applications for data analysis.
Results. According to data of the medical records the most common comorbidities (among those used to calculate CCI and CA-CCI) in patients with CAD below 75 yrs who underwent coronary artery stenting were cerebrovascular disease (83.3 ± 3.0%), peripheral vascular diseases (42,7±4,0%), type 2 diabetes mellitus, and mild liver diseases (24,0±3,6%). It was found that the number of comorbid diseases in patients having been examined ranged from 2 to 7, with an average of 3,9±0,1. The mean number of diseases in patients of different ages did not differ significantly. The average CA-CCI value increased from 4,4±0,2 points in patients who had two diseases to 12,7±1,1 points in those with seven ones (р<0,05).
Conclusions. Our study revealed a high prevalence of comorbidities in patients with CAD below 75 yrs who underwent coronary artery stenting. The use of CA-CCI allowed making a comprehensive assessment of patient’s conditions
FEATURES OF HEMOSTASIS IN DIFFERENT TYPES OF 24 HOURS DAY'S PROFILE OF BLOOD PRESSURE IN HYPERTENSIVE PATIENTS OF DIFFERENT AGE GROUPS
Authors: Pasko V.S. 
Published: July 2021

In most patients of both groups revealed changes in hemostasis in the direction of increasing the aggregation properties of platelets. However, more pronounced trends in such changes were found in patients with insufficient blood pressure at night.
Given the fact that not only in the absence of control over hypertension and failure to achieve target blood pressure levels, but also with different daily blood pressure profiles, there is a high probability of thrombotic complications. That is why it was important for us to find out the peculiarities of the state of platelet aggregation indicators depending on 24 hours day’s profile of blood pressure. To date there are only isolated reports of hemostasis in this category of individuals. We conducted such studies in middle-aged and elderly patients.
The aim of the study was to identify the baseline levels of hemostasis indices depending on 24 hours day’s profile of blood pressure in middle-aged and elderly hypertensive patients.
Material and methods. We performed the comparative assessment of status of hemostasis in 30 middle-aged (group I) and 30 elderly patients (group II) respectively to clarify this issue in our work. Patients of the surveyed groups were comparable in age, sex and related pathology. Control group consisted of 15 patients for every of the surveyed groups (group III the middle-aged and group IV the elderly respectively) matched with basic by age and gender.
Conclusions. Thus, in hypertensive patients there is an increase in platelet activity with age which is more pronounced when stimulating ADP in non-dipper group compared to dipper. In addition in older patients the most significant changes are determined in spontaneous and adrenaline-induced aggregation compared with middle-aged patients.
THE PRINCIPLES OF USING ESMOLOL IN THE PRACTICE OF AN ANESTHESIOLOGIST AND AN INTENSIVE CARE PHYSICIAN
Authors: Cherniy V. I. , Chernii T. V. , Shestak N.V. 
Published: July 2021

Aim of the study: to analyze the problem of using the beta-1-blocker esmolol for anesthetic management and intensive care from the sources of the modern available literature.
Materials and methods. Bibliosemantic, comparative and systems analysis. The proposed recommendations are based on data from the analysis of modern literature, the results of randomized studies and meta-analyzes devoted to the study of the problem of using the beta-1-blocker esmolol for anesthetic management and intensive care.
Results and discussion. Esmolol is the only ultrashort-acting selective beta-blocker for parenteral administration, which selectively blocks beta-1-adrenergic receptors mediating the cardiac stimulating effect of catecholamines. To a lesser extent, it affects the β2-adrenergic receptors of the bronchi and smooth muscles. At doses above 300 μg/kg per minute, the β1-selectivity of esmolol decreases, the drug competitively blocks β1- and β2-adrenergic receptors. Esmolol is most indicated in anesthetic practice for limiting the endocrine-metabolic response, reducing the risk of cardiac complications, reducing pain intensity, controlling hemodynamics, including ensuring controlled hypotension. The features of the pharmacokinetics of esmolol make it possible to accurately modulate the degree and duration of the decrease in heart rate and blood pressure, depending on the clinical situation, and make esmolol an "ideal" cardiac drug.
Conclusion. The use of ultrashort-acting beta-blockers increases the efficiency and safety of anesthesia, especially in high-risk patients, and creates the prerequisites for ensuring the best treatment results for patients in various fields of surgery.
SANOGENESIS OF PAIN SYNDROMES CAUSED BY DEGENERATIVE-DYSTROPHIC SPINE DAMAGE
Authors: Kvasnitskyi M.V. 
Published: July 2021

Aim. Explore different treatment approaches for degenerative-dystrophic damage of the spine and formulate the most effective treatment methods, their stage from accounting pathogenetic basis of pain syndromes.
Research methods – bibliosemantic, comparative, systemic.
Results. Diverse treatments for degenerative-dystrophic damage of the spine does not facilitate but even complicates general practitioner’s work due to the fact that information on clinical benefits of various drugs and techniques as well as various types of surgery is too contradictory; there is no single method of consistent, combination therapy for vertebrogenic pain. There is no universal therapy or surgery that would provide sustainable relief of symptoms of nonspecific back pain and/or radicular syndrome. The pathogenesis of development of specific clinical manifestations of the disease and the ratio of clinical manifestations and pathomorphological changes are crucial in choosing the treatment. The general principles of treatment are unchanged: rest, analgesics and movement should be combined in appropriate sanogenic proportions in each case. Reduction of oedema and swelling of the intervertebral disc and the spinal nerve root, nerve endings are crucial in regression of pain syndrome. There is no doubt that nonsteroidal anti-inflammatory drugs (NSAIDs) are the most effective in relieving lumbar and radicular pain at the beginning of treatment. In the absence of significant improvement after the use of NSAIDs and the necessary sanogenic motor loads, a more dynamic treatment should be used. First of all, different methods of local administration of pharmacological drugs: starting with the banal subcutaneous injection of painful areas and finishing with ultrasound and MRI-controlled injections directly into the area around the damaged nerve root, the epidural space, or the facet joint. In most cases, epidural injections can reach areas of disc-radicular conflict – after the drug is injected into the epidural space, favourable conditions are created for diffusion of glucocorticoids (or other pharmacological agents) into surrounding tissues, as well as the nerve root, regardless of its compression or irritation.
Conclusions. And only after the ineffectiveness of NSAIDs and puncture treatments, as well as epidural injection and in the case of persistent mechanical compression of nerve roots in comparison with clinical manifestations, appropriate surgical treatments, both minimally invasive and open, are necessary.
Efektivitas Ekstrak Kloroform Caulerpa racemosa Dalam Menghambat Pertumbuhan Bakteri Patogen Penyebab Infeksi Saluran Pernapasan Akut (ISPA)
Authors: Sampulawa Sriyati , Awan Ali , Rumahlatu Dominggus 
Published: July 2021

Acute respiratory infection is a serious health problem in the world and in Indonesia.Â Acute respiratory infection is caused by a variant of the bacteria and resistance to antibiotics. The Latest researches onÂ antibacterial compounds based on natural ingredients have been conducted.Â One of themÂ is derived from green algae. This study aims to determine the antibacterial activity of green algae Caulerpa racemosaÂ extract in inhibiting the growth of pathogenic bacteria causing acute respiratory infection. This study includes an extraction process using chloroform. Antibacterial testing wasÂ done by using a concentration of 0.5%, 1%, 5%, 10%, 20%, 40%, 60% and 80%, in order toÂ obtain the minimal Inhibitory Concentration. The results showed that C. racemosaÂ extract wasÂ able to inhibit the growth of test bacteria Streptococcus mitis, Bacillus anthrachis, and B.Â cereus, with the best activity at Â concentration of 0.5%Â andÂ 80%. Meanwhile the extract did not have the activity to inhibit the Gram-negative bacteria. Phytochemical test showedÂ that chloroform of C. racemosaÂ extract contain steroids and terpenoids compounds capable of inhibiting the growth of testingÂ bacteria.Â Key words: antibacterial activity, C. racemosa, pathogenic bacteria, Acute respiratory infection
Produksi Cabai Merah (Capsicum annuum L.) dari Benih yang Diinduksi Medan Magnet 0,2 mT dan Diinfeksi Jamur Fusarium sp.
Authors: Agustrina Rochmah , Manullang Herta M. , Irawan Bambang , Wahyuningsih Sri , Sumardi Sumardi 
Published: July 2021

As one of the horticultural plants that has important economic value, the cultivation of red chili (Capsicum annuum L.) is often constrained by the attack of Fusarium sp., which can cause losses due to decreased production. Induction of the magnetic field on the plant is known to be able to increase growth, development, and production in various plants.Â In this research, we studied the production of chili grown from seeds exposed to a 0.2 mT magnetic field and then infected with Fusarium sp. The study was conducted factorial using a completely randomized design with 2 factors. The first factor is the exposure of a 0.2 mT magnetic field to the seeds consisting of controls, without exposure to a magnetic field (M0), magnetic field exposure for 7 minutes 48 seconds (M7), and 15 minutes 30 seconds (M15). The second factor is Fusarium sp. infection on seeds that have been exposed to a magnetic field for 60 minutes by immersion of the seeds with spore suspension of Fusarium sp. with the density of 1 x 107 conidia/ml (F60), and without Fusarium sp. infection (F0). Each treatment unit was repeated 5 times. The data obtained were analyzed for variance at Î± = 5% followed by the least significant difference test using the Fishers Test at Î± = 5%. The results of data analysis showed that the interaction of 0,2 mT magnetic field exposure and infection of Fusarium sp. in chili seeds significantly affect the stomata index, the fruiting rate, and the number of fruit but do not affect the content of total chlorophyll, carbohydrate, as well as the number of flowers. The highest fruiting rate and number of fruits obtained from the treatment result of 0.2 mT magnetic field exposure for 15 minutes 36 seconds without Fusarium sp. infection (M15F0). Infection of Fusarium sp. in these seeds (M15F60) reduce the fruiting rate and the number of fruit but it is not significant and even almost similar with the fruiting rate and the fruit number of the plant growth from control treatment (M0F60).Â Â Key words: magnetic field, Fusariumsp., seed, and production.Â Â
Pengendalian Infeksi Bakteri Aeromonas hydrophila pada Ikan Nila (Oreochromis niloticus) dengan Ekstrak Rimpang Lengkuas Merah (Alpinia purpurata)
Authors: Sari Endang T.P. , Gunaedi Tri , Indrayani Ervina 
Published: July 2021

MAS diseases (Motile Aeromonas Septicaemia) is caused by the bacterium Aeromonas hydrophila. One of the natural ingredients that can be used as an alternative to inhibit bacterial activity is the extract of red galangal rhizome (Alpinia purpurata). Active substances possessed of this material have potential as antibacterial. The purpose of this study is to determine the effectiveness of red galangal rhizome extract in the control of MAS disease in tilapia. The type of this research is experimental research in Completely Random Design (RAL) with 6 treatments, which are positive control, negative control, 250, 500, 750, and 1000 ppm. The result of the research on the activity of the galangal extract bacteria on A. hydrophilaÂ obtained the widest clear zone at 1000 ppm constipation, which is 9.7625 mm. The treatment has been conducted by immersion of Tilapia fish into the extracted red galangan rgizomes for 5 minutes, then it was put into aquarium for maintenance for 7 days. 0.1 ml A. hydrophilaÂ (108Â cfu/ml) was injected to Tilapia. The result of the research on antibacterial shoes the wides clear zone at 1000 ppm with constipation, which is 9.7625 mm and the effectiveness test of red galangal extract on tilapia infected by A. hydrophilaÂ bacteria experience (ulcer) healing after 7 days with the concentration of rhizome extract of galangal 1000 ppm.Â Key words:Â red galangal rhizome extract, A. hydrophila, A. purpurata.
Study In Vitro: Kombinasi Herbal dan Probiotik sebagai Alternatif Antibiotic Growth Promoter
Authors: Prakasita Vinsa Cantya 
Published: July 2021

Antibiotic growth promoters (AGP) are widely used in animal feed for feed efficiency, stimulate growth, productivity and minimize mortality by preventing infection, but now its use has been officially banned by the government. As a result of the ban, many farmers or animal feed producer seek solutions in various ways such as the addition of herbs, probiotics, and a combination of both, but there are still few reports on the role of herbs, probiotics and a combination of both for alternative substitutes for AGP. This study aims to determine the role of herbs in the growth of probiotics. Herbs used ginger, turmeric, galingale, wild ginger, and temuireng, while the probiotics used are Bifidobacterium longum, B. bifidum, Bacillus sp., and Saccharomyces cereviciae. The benefits of herbs in supporting probiotics were tested using the disc diffusion method. Chloramphenicol disc ware used as control positive. Observation and measurement of the growth zone of probiotics were carried out after incubation. The results of this study prove that herbs do not inhibit the growth of probiotics. Herbal content can be a prebiotic candidate that can support the growth of probiotics. The combination of herbal-probiotics can potentially be an AGP substitute in animal feed.
Pengetahuan Tradisional Masyarakat Papua dalam Mengenali, Mengklasifikasi dan Memanfaatkan Pandan Buah Merah (Pandanus conoideus Lam.)
Authors: Zebua Lisye I. , Walujo Eko B. 
Published: July 2021

Study on traditional knowledge of Papua communities for recognizing, classifying, and utilizing the Red fruit PandanusÂ cultivar (PandanusconoideusÂ Lam.) have been carried out in four Papua regions (Arfak-Manokwari mountain, Serui, Cyclops-Jayapura mountain, and Jayawijaya District). Sampling method of research was interview and observation methods. Informans were selected using purposive samplingÂ and snowball sampling techniques. The data were analyzed on descriptive bases. The result showed that Papua communities have different knowledge of recognizing and managing the red fruit pandan. Characteristics used to distinguish cultivars were fruit size, seed size, and fruit colors. Based on ethno-biological data, there were two classification patterns of the red fruit in Papua. The first pattern were kingdom, life form, and specific structures.Â The second pattern were kingdom, life form, generic, and specific structures. The second pattern was similar to the botanical nomenclature. Utilization of the red fruit pandanwere morediverse in Papua communities living in mountainous than oher places, due to three important functions three functions, namely social, health, and economic functions. Utilization of the red fruit in Papua communities living in the bay areas were less varied, because the red fruit pandanwas only utilized as a food supplement. Generally, Papua communities living in the bay consumed the red fruit without being processed first.Key words:Â Classification, nomenclature, knowledgement, recognize, utilization.
Analisis Vegetasi Mangrove di Pulau Liki, Distrik Sarmi Kota Kabupaten Sarmi
Authors: Tanjung Rosye H.R. , Kabelen Agnes , Antoh Alfred 
Published: July 2021

Utilization of mangrove forest is very important for people who are on the island of Liki. This study aims to determine the species composition of mangrove, mangrove vegetation structure and ecological values in the Liki Island District of Sarmi Kota, Sarmi Regency, Papua Province. The method used in this research is the transect method, by observation, interviews, documentation and literature review. The results of the study and analysis of the data showed the discovery of the species composition as much as 5 species Â of 3 families with a density of 105 individuals/ha at tree level, 5 species of 3 families with a density of 124 individuals/ha at the level of the pole, 5 species of 3 families with a density of 149 people/ha at stake levels and 5 types of 3 families with a density of 109 individuals/ha at the seedling stage. The index value of the highest importance that kind of Bruguiera sexangulaÂ 78.02% at tree level. Mangrove species diversity at the level of the tree, sapling and seedling were low with H'<2.5. This research concludes that: 1). the composition of mangrove on Liki island consist of 5 species of 2). the low regeneration of mangroves causes the amount of density, frequency and dominance are relatively low; 3). need to increase the awareness of the public about the importance of the island of Liki themselves in maintaining the stability of mangrove land and sea conditions.Key words: vegetation analysis, mangrove species, Liki Island, Sarmi, Papua.
Implementasi Sistem Silvikultur TPTI dan TPTJ Teknik Silvikultur Intensif (SILIN) dalam Pengelolaan Hutan di Papua (Studi Kasus PT. Tunas Timber Lestari di Kabupaten Boven Digoel)
Authors: Unenor Erni , Tanjung Rosye H.R. , Keiluhu Henderina J. 
Published: July 2021

The application of silvicultural system which deviate from the existing policy leads to aberration of sustainable forest management conducted by IUPHHK holders. Hence observation for implementation in TPTI and TPTJ silvicultural system using SILIN Technique in forest management conducted by IUPHHK holders in Papua needs to be done. This study aims to determine the implementation of TPTI and TPTJ silvicultural system using SILIN Technique in forest management especially in terms of standing diameter increment accretion. Data analysis performed by calculating standing increment, which CAI = Yn-Yn-1 and MAI = Yn â€“Yo/Tn. The result shows that height and diameter increment (MAI) on TPTJ silvicultural system using SILIN Technique is higher than increment in PUP plot of TPTI silvicultural system. Therefore canopy openings, fertilizations, superior seeds plantations and environmental manipulation in silvicultural system with SILIN Technique contributes influence to standing growth rate, however TPTJ system showed reduction in diameter increment on fourth year measurement suspected by lackness in intensive silvicultural systemâ€™s main element. Observation are used in this study.Key words:Â CAI, MAI, TPTI and SILIN Technique.
Uji Efek Analgetik Infusa Daun Beluntas (Pluchea indica L.) Pada Mencit Jantan Galur Swiss
Authors: Wahyuningsih Sri S. , Widyastuti Linda 
Published: July 2021

Beluntas leaves (Pluchea indicaÂ L.) have been known as analgetic reducer. The study about this research has been going on right now. The goal ofÂ this research is to study the analgesic effect of beluntas (P. indica) leaf infused into male mice of swiss strain. The method used is the stretching chemical stimuli usingÂ acetic acid as an inducer of pain. Healthy male mice of Swiss strain were divided into five groups, and each group consisted of 5 mice. Group I was given paracetamol at a dose of 65Â mg/kgÂ of body weight, group II were given distilled water , the group III-V were given beluntasÂ leafÂ infuse in theÂ variation ofÂ 10 %, 20 % and 40 %.Â Thirty minutes after test substance application, acetic acid of 100 mg/kg of body weightÂ were givenÂ intraperitoneally in all groups and stretching of mice was observed every 5 minutes for 1 hour. The data was analyzed by using normality test of Kolmogorov-Smirnov; the Â test of homogeneity of variance was analyzed by ANOVA and post hoc tests were to differenciate the percentage analgetic of every group. Statistical test showed normal distributed and homogeneous data;Â there are significant differences of percentage analgesic between paracetamol and beluntas leaf infuse ofÂ 10, 20,Â and 40 % (pÂ < 0.05). There was significant differences between infuse of beluntas leaves with positive control (parasetamol) in mice.Â Key words: Analgetic, leaveÂ of beluntasÂ (P.Â indica), infuse, mice.