bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technique Using a Titanium Plate to Reconstruct the Inferior Sternal Cleft in Pentalogy of Cantrell: Lessons From Four Patients
Authors: Xi Linyun , Wu Chun , Pan Zhengxia , Xang Ming 
Published: April 2021

Abstract
BackgroundBy reviewing the outcomes of four patients, we summarize our experience with the strategy of using a titanium plate to reconstruct the inferior sternal cleft in pentalogy of Cantrell (POC).MethodsThis was a retrospective analysis of 4 patients who visited our department between January 2000 and June 2020 concurrent with POC. All four patients underwent an operation, as well as cardiac ultrasound and thoracoabdominal computed tomography (CT). Cardiac malformations achieved satisfactory correction according to echocardiographs. A titanium plate was used to repair the sternal and supraumbilical abdominal defects. The hospital course, operative data, and outpatient records were reviewed.ResultsAll 4 patients had partial sternal clefts, and 4 patients underwent a single-stage operation. All 4 cases of ectopia cordis were eventually repositioned. The defect in the sternum and supraumbilical abdomen was repaired using a titanium plate. One patient with double-outlet right ventricle (DORV) developed low cardiac output syndrome and pulmonary infection, and symptomatic treatment was administered until discharge. The mean follow-up time ranged from 9 months to 10 years. No patient developed pectus excavatum, and there were no cases of retrosternal seroma or pneumothorax. The titanium plate was migratory in the second patient and was dislodged at another hospital 3.5 years postoperation, and a fibreboard was formed in the area where sternal cleft; the beating heart could not be observed outside the thoracoabdominal or thoracic wall. In the first patient, the titanium plate was torn with a small fissure at 2 years postoperation, but the fissure was not enlarged during follow-up. In the other two patients, the appearance of both the abdominal wall and lower sternum and cardiac function were good. The New York Heart Association function class was I in all four patients.ConclusionThe use of a titanium plate to construct the neosternum can yield a satisfactory exterior appearance of the thorax with a partial sternal cleft, but long-term outcomes need to be examined further.
Materials degradation in non- thermal plasma generators by corona discharge
Authors: Cogollo Mar , Arrabal Adrián López , Lantada Andrés Díaz , Aguirre M. Vega 
Published: April 2021

Abstract
Atmospheric corona discharge devices are being studied as innovative systems for cooling, sterilization and propulsion, in several industrial fields, from robotics to medical devices, from drones to space applications. However, their industrial scale implementation still requires additional understanding of several complex phenomena, such as corrosion, degradation and fatigue behaviour, which may affect final system performance. This study focuses on the corrosive behaviour of wires that perform as a high-voltage electrodes subject to DC positive corona discharge in atmospheric air. The experiments demonstrate that the non-thermal plasma process promotes the growth of the oxidative films and modifies the physicochemical properties of the materials chosen as corona electrodes, hence affecting device operation. Surfaces exposed to this non-thermal plasma are electrically characterized by negative exponential decay of time-depend power and analysed with SEM. Implications on performance are analysed and discussed.
Microchannel Porous Hydroxyapatite Scaffold Promotes Osteogenic Differentiation by Altering the Expression of miRNAs
Authors: Deng Li , Qing Wei , Huang Lijuan , Liu Cong , Zheng Jiajun , Huang Hao , Peng Pairan , Lai Shuang , Huang Jie , Mu Yandong 
Published: April 2021

Abstract
Hydroxyapatite is a commonly used scaffold material for bone tissue engineering. However, the osteogenic mechanism of hydroxyapatite scaffolds remains unclear. Recently, we have prepared a hydroxyapatite scaffolds with microchannels and porous structures (HAG) which have good osteogenic effects in vitro and in vivo. In present study, we explained the mechanism of HAG scaffolds promoted the osteogenic differentiation from the perspective of miRNA differential expression. We used microarray assays to analyze the expression profiles of miRNAs from the osteogenic differentiation of hPMSCs with or without HAG; 16 miRNAs were upregulated and 29 miRNAs were downregulated between the two types of cells. And overexpression the differential miRNAs could promote the osteogenic differentiation of hPMSCs. Additionally, gene ontology analysis, pathway analysis, and miRNA-mRNA-network built were performed to reveal that the differentially expressed miRNAs participate in multiple biological processes, including cell metabolic, cell junction, cell development, differentiation, and signal transduction, among others. Furthermore, we found that these differentially expressed miRNAs connect osteogenic differentiation to processes such as axon guidance, MAPK, and TGF-beta signaling pathway. This is the first study to identify and characterize differentiational miRNAs derived from HAG-hPMSC cells.
A novel non-invasive method for detection of breast and ovarian cancer using volatile organic compounds from urine sample
Authors: Nakrani Mital , Doshi Pooja , Joshi Chaitanya , Joshi Madhvi 
Published: April 2021

Abstract
The present study describes a novel method for early diagnosis of breast and ovarian cancer from urine samples using a non-invasive method by determining the level of the selected volatile organic compounds (VOCs). In this study, solvent (hexane) was used for the extraction of VOCs and further detected using GC-MS. Total twenty-six compounds were analyzed, out of which, six (Naphthalene; 2-methylOctacosane; Benzaldehyde 2,5dimethyl; 11-Methyldodecanol; Heptane 2,4 dimethyl, and 2,4-Dimethylhept-1-ene) were found to be uniquely present in breast and ovarian cancer patients. These six VOCs could be used as potential biomarkers for early diagnosis of breast and ovarian cancer. Out of these six, two compounds (2-methylOctacosane and 11-Methyldodecanol) were detected for the first time in the aforementioned cancer patients. Quantitation of the remaining twenty VOCs common to both control individuals and subjects revealed significant log2 fold change (P-value<0.05) range from-0.7 to 1.4. The maximum decrease in the concentration level was observed in pentadecane and the maximum increase was observed in trans-1, 2-Diethyl cyclopentane in cancer subjects as compared to the control individuals. The present study may be used to identify these compounds simultaneously from the urine that are potential biomarkers for the diagnosis of breast and ovarian cancer.
Proteoglycan-4 is an Essential Regulator of Synovial Macrophage Polarization and Inflammatory Macrophage Joint Infiltration
Authors: Qadri Marwa , Jay Gregory D. , Zhang Ling X. , Schmidt Tannin A. , Totonchy Jennifer , Elsaid Khaled Ahmed 
Published: April 2021

Abstract
Background: Synovial macrophages (SMs) perform a multitude of functions that include clearance of cell debris and foreign bodies, tissue immune surveillance, and resolution of inflammation. At one end of the macrophage polarization spectrum is the inflammatory phenotype (M1), which secretes IL-1β, IL-6 and expresses iNOS. On the opposite end of the spectrum is the anti-inflammatory phenotype (M2) which is characterized by the secretion of IL-10 and TGF-β. PRG4 is an important regulator of synovial hyperplasia and fibrotic remodeling and the involvement of SM activation in PRG4’s homeostatic role is yet to be defined. Our objectives were to study PRG4’s importance to SM homeostasis, M1 and M2 polarization and joint infiltration of bone marrow-derived macrophages (BMDMs) and investigate the role of SMs in mediating synovial fibrosis in Prg4 gene-trap (Prg4GT/GT) murine knee joints.Methods: SM phenotyping in Prg4GT/GT and Prg4+/+ joints was performed using flow cytometry and the balance between CD86+/CD206- (M1) and CD86-/CD206+ (M2) SMs was studied as animals aged. Expression of iNOS and IL-6 in CD86+ SMs, arginase-1 in CD206+ SMs and the impact of Prg4 recombination on SM polarization and BMDM infiltration following a TLR2 agonist challenge were determined. Inflammatory SMs were depleted using liposomal clodronate and synovial membrane thickness and expression of fibrotic markers: α-SMA, PLOD2 and collagen type I (COL-I) were assessed using immunohistochemistry.Results: Total macrophages in Prg4GT/GT joints were higher than corresponding age-matched Prg4+/+ joints (p<0.0001) and the percentages of CD86+/CD206- and CD86+/CD206+ SMs increased in Prg4GT/GT joints as animals aged (p<0.0001), whereas the percentage of CD86-/CD206+ SMs decreased (p<0.001). CD86+ SMs expressed iNOS and IL-6 compared to CD86- SMs (p<0.0001) while CD206+ SMs also expressed arginase-1. Prg4 re-expression limited the accumulation of CD86+ SMs, increased CD86-/CD206+ SMs and attenuated BMDM recruitment (p<0.001). Liposomal clodronate reduced inflammatory SMs and in turn reduced synovial hyperplasia, α-SMA, PLOD2 and COL-I expression in the synovium (p<0.0001).Conclusions: SM accumulation in the joint and the balance between inflammatory and anti-inflammatory SM subsets are regulated by PRG4. In the absence of PRG4’s role, the synovium is populated with inflammatory macrophages that drive synovial fibrosis.
Design and Optimization of a Novel Hydro Cylinder Displacement Sensor
Authors: Zhou Jie , Wen Zhiguo , Ren Huaiwei , Han Zhe , Gong Shixin 
Published: April 2021

Abstract
In recent years, the coal mine intelligent development process has constantly advanced, putting forward higher requirements for monitoring mining equipment data. Sensor technology suitable for the special underground environment has also been developing. Hydraulic support is a key piece of equipment in fully mechanized coal mining. Monitoring the hydraulic support position and attitude has been an important part of coal mine intelligent development. In the present paper, a new oil cylinder displacement sensor was proposed. The oil cylinder translational motion was transformed into the magnet rotary motion via the motion conversion mechanism. The magnet angle was calculated by utilizing the single-chip microcomputer, and the oil cylinder expansion and contraction were calculated via the filtering algorithm. Results showed that the sensor accuracy could reach 0.5 mm. In recent years, the coal mine intelligent development process has constantly advanced, putting forward higher requirements for monitoring mining equipment data. Sensor technology suitable for the special underground environment has also been developing. Hydraulic support is a key piece of equipment in fully mechanized coal mining. Monitoring the hydraulic support position and attitude has been an important part of coal mine intelligent development. In the present paper, a new oil cylinder displacement sensor was proposed. The oil cylinder translational motion was transformed into the magnet rotary motion via the motion conversion mechanism. The magnet angle was calculated by utilizing the single-chip microcomputer, and the oil cylinder expansion and contraction were calculated via the filtering algorithm. Results showed that the sensor accuracy could reach 0.5 mm.
Social and emotional loneliness among college students during the COVID-19 pandemic: the predictive role of coping behaviours, social support, and personal resilience
Authors: Labrague Leodoro J. , Santos Janet Alexis A. De los , Falguera Charlie 
Published: April 2021

Abstract
ObjectiveTo determine the influence of coping behaviors, resilience, and social support on students' emotional and social loneliness during the COVID‐19 pandemic.Design and MethodsA cross‐sectional research design was used to gather data from 303 college students from the Central Philippines using four standardized scales through an online survey.FindingsLoneliness among students was high during the coronavirus pandemic. Resilience, coping behaviors, and social support were identified as protective factors against loneliness.Practice ImplicationsInterventions directed toward increasing resilience, social support, and coping behaviors may help decrease emotional and social loneliness caused by the mandatory lockdown during the COVID‐19 pandemic.
Associations between insecure attachment styles to parents and suicidal ideation in adolescents with depression
Authors: Waraan Luxsiya , Mehlum Lars , Rognli Erling W. , Czajkowski Nikolai O. , Aalberg Marianne 
Published: April 2021

Abstract

Objective:
Suicidal ideation and depressive symptoms are often interrelated in clinical settings. Insecure attachment may be a risk factor for suicidal ideation in depressed adolescents. To our knowledge, this study is the first to examine the association between self-reported insecure attachment styles to both parents and suicidal ideation in a clinical sample of adolescents with depression.

Methods:
Fifty clinically depressed adolescents (13-17 years, 84% girls) completed self-reported measures of suicidal ideation, depressive symptoms, and attachment style to parents.

Results:
There was a statistically significant bivariate association between higher levels of attachment anxiety in relation to mothers and fathers and higher levels of suicidal ideation. When attachments to both parents were included in the same multivariate model, only attachment anxiety to the mother was significantly associated with the level of suicidal ideation. Self-reported depressive symptoms remained significantly associated with the level of suicidal ideation in all analyses. Younger adolescents with attachment anxiety reported higher levels of suicidal ideation than older adolescents.

Conclusion:
Conclusions about directionality and causality of associations between insecure attachment and suicidal ideation are limited due to the cross-sectional design. Our findings suggest that attachment anxiety in relation to the mother and father is associated with increased levels of suicidal ideation. Implication of these findings for treatment selection is discussed.
Revealing the membrane fouling mechanism caused by the denitrification filter effluent during ozonation by model assessment
Authors: Bai Yuan , Wu Yin-Hu , Tong Xin , Wang Yun-Hong , Ikuno Nozomu , Wang Wei , Shi Yu-Long , Hu Hong-Ying 
Published: April 2021

Abstract
Membrane fouling has been a major obstacle for stable operation of ultrafiltration. In this study, prevailing fouling models were applied to assess the fouling behavior of the denitrification filter (DNF) effluent during ozonation. In order to clarify the fouling mechanism, correlation analysis and redundancy analysis (RDA) were conducted to investigate the correlations among model parameters, fouling potential and water features of the DNF effluent. The combined intermediate-standard model exhibited superior determination coefficients (R2 &gt; 0.99). Based on analytical results, the model parameter of intermediate blocking (Ki) and standard blocking (Ks) was fairly applicable to describe the fouling of higher molecular weight (F1, MW &gt;4,000 Da) and lower molecular weight fractions (F2, MW = 2,000–4,000 Da and F3, MW &lt; 2,000 Da), respectively. In comparison, F1 played a predominant role in the fouling behavior of the DNF effluent. Increased ozone dosage resulted in decreased membrane fouling contribution of F1 and increased fouling contribution of F2 and F3 during ozonation. The change of fouling contributions was attributed to the transformation of high MW fractions into lower MW fractions by ozonation. This study clarified the relationships between model parameters and the membrane fouling process caused by organic fractions with specific molecular weight, thus demonstrating the membrane fouling mechanism of the DNF effluent during ozonation.
Novas práticas de ensino em tempos de pandemia: tutorial de acesso a salas de aula virtuais
Authors: Carvalho Milena , Ferreira Junior Moacir Natercio 
Published: April 2021

O objetivo deste trabalho é apresentar um tutorial sobre o acesso à plataforma de aulas on-line Google Classroom para os estudantes do Centro Interescolar de Línguas de Recanto das Emas, uma cidade na periferia de Brasília, capital do Brasil. O objetivo do tutorial é apresentar aos estudantes, de forma lúdica e com linguagem simples, a realização do acesso à plataforma, haja vista as dificuldades relatadas pelos estudantes ao tentarem o acesso a tal mecanismo. No contexto da pandemia COVID-19, o ensino presencial nas escolas foi suspenso, dando lugar ao ensino remoto. Visto que muitos estudantes de nossa cidade vivem em situação de vulnerabilidade socioeconômica, o acesso à tecnologia é restrito, fazendo com que muitos deles tenham dificuldades operacionais ao acessarem as tecnologias no contexto de ensino remoto. A repercussão do tutorial foi muito positiva, alcançou diversas cidades e este foi apresentado pelo próprio Secretário de Educação da Secretaria de Estado de Educação do Distrito Federal como uma “ferramenta facilitadora do acesso”. O tutorial foi apresentado em jornais locais e em redes de televisão como uma ferramenta prática, lúdica e esclarecedora sobre como acessar a plataforma Google Classroom, possibilitando a um grande número de estudantes o acesso ao ensino remoto.
Agradecimentos:
Gostaríamos de agradecer à equipe de gestão do CEd 104 do Recanto das Emas e ao Professor Moacir Natercio Ferreira Júnior pela assistência durante o desenvolvimento deste trabalho.
Former and present attractiveness of industrial sectors in the development process of Poland and Mazovia
Authors: Karpiński Andrzej 
Published: April 2021

In the current discussions on the past and future prospects of industry in Poland, at least four areas require, in my opinion, much more attention and reflection. This means learning from our – not always positive – experiences. Four matters are the most pressing, and I believe that getting answers to the following four questions is of the utmost urgency: 1) What measures to stimulate development, what we sometimes call the “anatomy of growth or development”, were applied to the industry in Poland in the initial period of its transformation and during the first 25 years – 1990-2014. Among others, what factors initiated the development, propelled it and contributed conclusively to its further growth, and whether and what changes are currently required? 2) If the state decides to support the development of selected branches and areas of industry that offer the greatest development opportunities – what should be the criteria for their selection and whether they require addenda or corrections? 3) What changes were made in these industries which were recognized as having the greatest development opportunities in the initial period of the abovementioned Polish transformation? What conclusions should be drawn from the changes currently taking place in them? 4) Which branches of industry are and may be the most attractive for development in Warsaw and Mazovia region? In each of these four areas, there have recently been many new addenda to the existing diagnoses and proposals which seem to be worthy of discussion.
A Prediction Model for Detecting Developmental Disabilities in Preschool-Age Children Through Digital Biomarker-Driven Deep Learning in Serious Games: Development Study
Authors: Kim Ho Heon , An Jae Il , Park Yu Rang 
Published: April 2021

Background
Early detection of developmental disabilities in children is essential because early intervention can improve the prognosis of children. Meanwhile, a growing body of evidence has indicated a relationship between developmental disability and motor skill, and thus, motor skill is considered in the early diagnosis of developmental disability. However, there are challenges to assessing motor skill in the diagnosis of developmental disorder, such as a lack of specialists and time constraints, and thus it is commonly conducted through informal questions or surveys to parents.

Objective
This study sought to evaluate the possibility of using drag-and-drop data as a digital biomarker and to develop a classification model based on drag-and-drop data with which to classify children with developmental disabilities.

Methods
We collected drag-and-drop data from children with typical development and developmental disabilities from May 1, 2018, to May 1, 2020, via a mobile application (DoBrain). We used touch coordinates and extracted kinetic variables from these coordinates. A deep learning algorithm was developed to predict potential development disabilities in children. For interpretability of the model results, we identified which coordinates contributed to the classification results by applying gradient-weighted class activation mapping.

Results
Of the 370 children in the study, 223 had typical development, and 147 had developmental disabilities. In all games, the number of changes in the acceleration sign based on the direction of progress both in the x- and y-axes showed significant differences between the 2 groups (P<.001; effect size >0.5). The deep learning convolutional neural network model showed that drag-and-drop data can help diagnose developmental disabilities, with an area under the receiving operating characteristics curve of 0.817. A gradient class activation map, which can interpret the results of a deep learning model, was visualized with the game results for specific children.

Conclusions
Through the results of the deep learning model, we confirmed that drag-and-drop data can be a new digital biomarker for the diagnosis of developmental disabilities.
Redes sociales y salud mental: vivencias digitales de alumnos de la FES-I UNAM
Authors: Barrón-Colin Mariana , Mejía-Alvarado César Abraham 
Published: April 2021

<p><strong><span>Introducción:</span></strong><span> Los individuos se desarrollan ambivalentemente en entornos tangibles y virtuales donde experimentan vivencias que definen su relación con las comunidades y la representación de sí mismo. Las redes sociales han permitido un avance en la comunicación y relaciones interpersonales, impactando en la salud de los usuarios. <strong>Metodología: </strong>Investigación cualitativa, con diseño fenomenológico descriptivo, que aborda vivencias exteriorizadas a partir de entrevistas semiestructuradas, participaron cuatro estudiantes elegidos con base en el típico ideal, los criterios de rigor aplicados fueron credibilidad y confirmabilidad, se tomaron en cuenta aspectos éticos contemplados en la Ley General de Salud. <strong>Objetivo:</strong> Describir las vivencias de estudiantes de la carrera de enfermería entorno al uso de redes sociales. <strong>Hallazgos:</strong> Los jóvenes son un grupo vulnerable importante al presentar ansiedad, referido por los participantes, derivado de la convivencia digital, aspecto ligado estrechamente a las vivencias en las redes sociales a razón de sus interacciones personales, tiempo de uso y su identidad en el entorno virtual. Estos hallazgos sugieren que la personalidad del usuario será confrontada en esta dinámica digital. <strong>Conclusión:</strong> La forma de comunicación y relación ha evolucionado, el efecto de las redes sociales repercute directamente en la salud mental, positiva o negativamente, la prevención, promoción a la salud y bienestar psicoemocional es un área donde enfermería debe romper paradigmas, desde su área de intervención, identificando problemáticas del continuo de salud de los individuos al ser seres holísticos, la tecnología progresará, pero con ella, los retos en el primer nivel de atención.</span></p>