bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solubility Study of Acetylsalicylic Acid in Ethanol + Water Mixtures: Measurement, Mathematical Modeling, and Stability Discussion
Authors: Nokhodchi Ali , Ghafourian Taravat , Nashed Nour , Asare-Addo Kofi , Behboudi Elmira , Sefid-Sefidehkhan Yasaman , Zarghampour Aynaz , Rahimpour Elaheh , Jouyban Abolghasem 
Published: December 2021

AbstractSolubility determination of poorly water-soluble drugs is pivotal for formulation scientists when they want to develop a liquid formulation. Performing such a test with different ratios of cosolvents with water is time-consuming and costly. The scarcity of solubility data for poorly water-soluble drugs increases the importance of developing correlation and prediction equations for these mixtures. Therefore, the aim of the current research is to determine the solubility of acetylsalicylic acid in binary mixtures of ethanol+water at 25 and 37°C. Acetylsalicylic acid is non-stable in aqueous solutions and readily hydrolyze to salicylic acid. So, the solubility of acetylsalicylic acid is measured in ethanolic mixtures by HPLC to follow the concentration of produced salicylic acid as well. Moreover, the solubility of acetylsalicylic acid is modeled using different cosolvency equations. The measured solubility data were also predicted using PC-SAFT EOS model. DSC results ruled out any changes in the polymorphic form of acetylsalicylic acid after the solubility test, whereas XRPD results showed some changes in crystallinity of the precipitated acetylsalicylic acid after the solubility test. Fitting the solubility data to the different cosolvency models showed that the mean relative deviation percentage for the Jouyban-Acree model was less than 10.0% showing that this equation is able to obtain accurate solubility data for acetylsalicylic acid in mixtures of ethanol and water. Also, the predicted data with an average mean relative deviation percentage (MRD%) of less than 29.65% show the capability of the PC-SAFT model for predicting solubility data. A brief comparison of the solubilities of structurally related solutes to acetylsalicylic acid was also provided.
Age-Specific Clinical Features of Pediatric Malignant Hyperthermia: A Review of 187 Cases Over 60 Years in Japan
Authors: Otsuki Sachiko , Miyoshi Hirotsugu , Mukaida Keiko , Yasuda Toshimichi , Nakamura Ryuji , Tsutsumi Yasuo M. 
Published: December 2021

BACKGROUND:
Malignant hyperthermia (MH) is an inherited muscle disorder induced by volatile anesthetics and depolarizing muscle relaxants. While the incidence of MH is high in young, there are few reports on the clinical features of pediatric MH. In this study, we selected pediatric cases from an MH database and analyzed the clinical findings by age group. We hypothesized that there would be age-related differences in the clinical characteristics.

METHODS:
A retrospective analysis of MH data collected in our database during 1960 to 2020 was performed to identify pediatric subjects (≤18 years) with a Clinical Grading Scale of ≥35, indicating “very likely” or “almost certain” MH. We compared clinical characteristics among the 0 to 24 month, 2 to 12 year, and 13 to 18 year (youngest, middle, and oldest, respectively) age groups.

RESULTS:
Data were available for 187 patients: 15 in the youngest age group, 123 in the middle-aged group, and 49 in the oldest age group. Of these, 55 patients (29.4%) had undergone muscle biopsy and muscle contracture test. The mortality rates during the study period were 13.3%, 13.8%, 20.4%, and 15.5% in the youngest, middle, and oldest cohorts and overall, respectively. In contrast, the overall mortality rate from 2000 to 2020 was 8.8%. The most frequent initial symptoms of MH were elevated temperature (46.7%) and generalized muscular rigidity (26.7%) in the youngest cohort, masseter spasm (35.0%) and generalized muscular rigidity (19.5%) in the middle cohort, and elevated end-tidal carbon dioxide (26.5%) and tachycardia (22.4%) in the oldest cohort. Physical examination revealed that elevated temperature, sinus tachycardia, and respiratory acidosis occurred frequently in all groups. The middle cohort had high frequencies of masseter spasm (58.4%; P = .02) and dark urine (75.5%; P = .01) compared to those in the oldest groups, and had a higher peak creatine kinase level compared to those in the 3 groups. Skeletal muscle symptoms tended to be more common in patients administered succinylcholine (generalized muscular rigidity, P = .053; masseter spasm, P < .0001; dark urine, P < .0001). In particular, masseter spasm and dark urine were more common in the middle cohort when succinylcholine was administered (masseter spasm: versus youngest cohort, P = .06, versus oldest cohort, P = .027; dark urine: versus youngest cohort, P = .0072, versus oldest cohort, P = .0015).

CONCLUSIONS:
The clinical characteristics of pediatric patients with MH vary according to age group. The difference in initial symptoms of MH depending on age group is noteworthy information for the early diagnosis of MH.
A Multifunctional Luminescence Metal-Organic Framework Sensor for the Neuropathy Biomarker Glutamic Acid
Authors: Zhang Yakun , Zhao Lefa , Gao Ce 
Published: December 2021

Abstract
Herein, a well-designed nanohybrid Fe-MIL-88NH2 with regular octahedral structure was facilely fabricated by one-step hydrothermal strategy, which as a probe presents good fluorescent stability and sensitive discrimination for Glu in aqueous solution with a detection limit of 2.04 µM. Inspired by the predominant fluorescence property of Fe-MIL-88NH2, the biological application of the probe was conducted to evaluate the degrees of Glu in Hela cells with pleasing results. Furthermore, the visualized and user-friendly handy test strips for monitoring the levels of Glu in waste water have been designed, which exhibited a satisfactory visual phenomenon and could be visualized by naked eye.
Electrochemical Preparation of Highly Oriented Microporous Structure Nickel Oxide Films as Promising Electrodes in Urea Oxidation
Authors: Putri Yulia M T A , Gunlazuardi Jarnuzi , Ivandini Tribidasari A 
Published: December 2021

Abstract
Highly oriented microporous nickel oxide films were prepared through the simple and fast anodization of nickel foils at 30 V, followed by calcination at 400 °C. Low concentrations of ammonium chloride and potassium hydroxide solutions, which were dispersed in ethylene glycol, were used as electrolytes. Microporous dimensions and large surface areas of the films were obtained by using both electrolytes. The ammonium chloride system provided a highly oriented microporous structure with excellent distribution of pores at the surface of nickel foil. On the contrary, it was not uniform in the potassium hydroxide system. Furthermore, cyclic voltammetry of the microporous films in alkaline solutions containing urea showed the highest oxidation currents at the nickel oxide films prepared in the ammonium chloride system. This nickel oxide film also showed excellent stability of the current responses, indicating that the method has potential to be applied in electrode preparation, especially urea oxidation.
Diffusion Approximations for a Class of Sequential Experimentation Problems
Authors: Araman Victor F. , Caldentey René A. 
Published: December 2021

A decision maker (DM) must choose an action in order to maximize a reward function that depends on the DM’s action as well as on an unknown parameter Θ. The DM can delay taking the action in order to experiment and gather additional information on Θ. We model the problem using a Bayesian sequential experimentation framework and use dynamic programming and diffusion-asymptotic analysis to solve it. For that, we consider environments in which the average number of experiments that is conducted per unit of time is large and the informativeness of each individual experiment is low. Under such regimes, we derive a diffusion approximation for the sequential experimentation problem, which provides a number of important insights about the nature of the problem and its solution. First, it reveals that the problems of (i) selecting the optimal sequence of experiments to use and (ii) deciding the optimal time when to stop experimenting decouple and can be solved independently. Second, it shows that an optimal experimentation policy is one that chooses the experiment that maximizes the instantaneous volatility of the belief process. Third, the diffusion approximation provides a more mathematically malleable formulation that we can solve in closed form and suggests efficient heuristics for the nonasympototic regime. Our solution method also shows that the complexity of the problem grows only quadratically with the cardinality of the set of actions from which the decision maker can choose. We illustrate our methodology and results using a concrete application in the context of assortment selection and new product introduction. Specifically, we study the problem of a seller who wants to select an optimal assortment of products to launch into the marketplace and is uncertain about consumers’ preferences. Motivated by emerging practices in e-commerce, we assume that the seller is able to use a crowd voting system to learn these preferences before a final assortment decision is made. In this context, we undertake an extensive numerical analysis to assess the value of learning and demonstrate the effectiveness and robustness of the heuristics derived from the diffusion approximation. This paper was accepted by Omar Besbes, revenue management and market analytics.
A Institucionalização das redes Sociais On-Line pela Polícia Militar: ameaça ou oportunidade?
Authors: de Sousa Ferreira Daniel Victor , Martins Alves Ana Luisa , Rodrigues de Oliveira Cintia 
Published: December 2021

Este caso para ensino em administração pública estimula reflexões e debates sobre a gestão na condução de políticas públicas de segurança em uma cidade de médio porte no interior do Brasil, denominada aqui pelo nome fictício de Gotatina. Para além do anseio por serviços públicos de qualidade e participação social, incluiu-se, desde março de 2020, o regime de isolamento social no combate à pandemia do Covid-19, que trouxe às práticas de policiamento comunitário enorme desafios. Ao articular os pressupostos da Polícia Comunitária e os temas relacionados à gestão pública, o caso potencializa um espaço para o debate de ideias relacionadas à cidadania e à democracia das instituições policiais, em cursos de graduação e pós-graduação em Administração e Administração Pública, especialmente em disciplinas que envolvam e-Governo, Negociação, Gestão participativa.
Iatrogenic Esophagopleural Fistula After the Management of Acute Variceal Hemorrhage With Minnesota Tube Placement
Authors: White Rachel V. , Lee Roland Y. , Shin Benjamin J. , Birkholz James H. 
Published: December 2021

ABSTRACT
An esophagopleural fistula (EPF) is a rare condition. EPFs are typically of spontaneous, iatrogenic, or neoplastic origin. A 50-year-old man with hepatitis C and alcoholic cirrhosis presented with a history of recurrent variceal hemorrhage requiring esophageal banding, Minnesota tube placement, and a transjugular intrahepatic portosystemic shunt. His hospital course after esophageal perforation and EPF was complicated by acute respiratory failure and empyema, necessitating intubation and thoracostomy tube placement. To the best of our knowledge, this is the first reported case of EPF secondary to Minnesota tube placement. The EPF completely healed after endoscopic repair.
Diagnosis of Gastric Cancer in the Excluded Stomach After RYGB by Jejunogastrostomy Using a LAMS
Authors: Schneider Luca , Kröger Arne , Gubler Christoph , The Frans O. 
Published: December 2021

ABSTRACT
For patients after bariatric surgery, diagnosis of gastric cancer is a challenge. We present a patient after Roux-en-Y gastric bypass with upper abdominal pain and abnormal computed tomography scan with diffuse wall thickening of the gastric antrum. Various biopsy techniques have been described, with surgical (laparoscopic) exploration being the most common. We were able to successfully diagnose gastric cancer in the excluded stomach by biopsy using a jejunogastrostomy, which proved to be safe and effective.
Vedolizumab Therapy in Refractory Enteropathy Associated With CVID
Authors: Johnson Dane , Lee Goo , Weber Frederick 
Published: December 2021

ABSTRACT
Common variable immunodeficiency (CVID) is a disorder of typically adult-onset hypogammaglobulinemia in the absence of other known causes. Noninfectious gastrointestinal tract manifestations are common, and a subset of patients with CVID present with a severe enteropathy manifesting as severe malabsorption, weight loss, and diarrhea. A 63-year-old man presented with CVID and severe enteropathy who failed to improve with cytomegalovirus therapy, multiple empiric therapies, and corticosteroids. Vedolizumab infusions were initiated with a dramatic, rapid, and durable complete clinical response.
Evidentiality and other types readjusted: Interpersonal modality revisited
Authors: Zhou Jiangping 
Published: December 2021

AbstractInterpersonal modality, bifurcating modalization and modulation, is an important construct of interpersonal meaning in the architecture of Systemic Functional Linguistics. By meticulously reviewing relevant studies from the perspectives of traditional modality and modality’s semantic map, three respects with respect to the system of interpersonal modality have been supplemented. Firstly, modalization, being subcategorized into possibility and usuality, is suggested to entertain evidentiality from the traditional sense. Secondly, considering the delicacy of the system of interpersonal modality, possibility in modalization should be further categorized into epistemic and root possibility; necessity as one subtype of modulation, superseding the original obligation in modulation, is subclassified into obligation and permission; inclination, being the other subtype of modulation, should be specified as the superordinate of volition and ability. Thirdly, the shifting of modal meanings from root possibility to epistemic possibility in modalization and from inclination to necessity in modulation should be clearly specified as far as language evolvement is concerned.
Exploring ecological identity from the perspective of systemic functional linguistics
Authors: Lei Lei 
Published: December 2021

AbstractEcological identity, acting as the baton to guide the public’s behavior in nature, is closely correlated with environmental crises that threaten human survival. Previous studies of ecological identity are mostly conducted in the domain of sociopsychology with an emphasis on human’s attitude and behavior. Less attention, however, has been paid to the discursive construction of one’s ecological identity. The current study aims to build a framework to explore the mechanism of discursive strategies in constructing one’s ecological identity. To this end, this article classifies different ecological identities according to their impact on nature and the ecosophy of holism. It then puts forward a framework based on systemic functional linguistics to explore how lexicogrammatical resources can be employed strategically in the construction of ecological identity. The framework is significant for ecolinguistic investigations of identity and the cultivation of human’s critical language awareness related to the protection of ecosystems.
Controllable morphology of Bi2S3nanostructures formedviahydrothermal vulcanization of Bi2O3thin-film layer and their photoelectrocatalytic performances
Authors: Liang Yuan-Chang , Li Tsun-Hsuan 
Published: December 2021

AbstractBi2S3nanostructures with various morphologies were synthesized through hydrothermal vulcanization at different sulfur precursor (thiourea) concentrations. A 100 nm thick sputter-deposited Bi2O3thin-film layer on a fluorine-doped tin oxide glass substrate was used as a sacrificial template layer. The etching of the Bi2O3sacrificial template layer and the regrowth of Bi2S3crystallites during hydrothermal vulcanization produced the different Bi2S3nanostructure morphologies. The lowest sulfur precursor concentration (0.01 M) induced the formation of Bi2S3nanosheets, whereas the Bi2S3nanoribbons and nanowires were formed with increased sulfur precursor concentrations of 0.03 and 0.1 M, respectively. These results indicate that sputter-deposited Bi2O3thin-film layers can be effectively used to form low-dimensional Bi2S3crystals with controllable morphologies. Among the various Bi2S3samples, the Bi2S3nanosheets exhibited superior photoactive ability. The higher active surface area, surface defect density, light absorption capacity, and photo-induced charge separation ability of Bi2S3nanosheets explain their superior photoelectrocatalytic degradation ability of rhodamine B dyes.
¿Hacia una teoría de la administración en América Latina?
Authors: BALLINA RIOS FRANCISCO 
Published: December 2021

El objetivo de este artículo es indagar qué tanto ha evolucionado la disciplina administrativa como técnica o como episteme, en el contexto latinoamericano. Se plantea que la teoría latinoamericana de la administración enfrenta una doble problemática: la epistemológica, por su falta de consistencia y coherencia interna, y la sociológica, debido a que su aparato conceptual está constituido de enfoques técnicos, ligados a procesos de producción a nivel mundial de corte pragmático-racionalistas; esta teoría administrativa, se fundamenta en el liberalismo económico, en modelos gerenciales provenientes en forma dominante de Europa y Estados Unidos, así como Japón. Asimismo, se busca describir sintéticamente hacia dónde se dirigen las agendas alternativas de investigación en administración para superar este escollo, mediante una conceptualización del papel que en nuestras sociedades juegan las empresas y las organizaciones.
Kebutuhan Pengembangan Media Pembelajaran iSpring Suite Berbasis Android Pada Mata Pelajaran Morfologi Bahasa Arab
Authors: Fikrotin Vera , Sulaikho Siti 
Published: December 2021

Learning media is an important component so that the process of teaching and learning activities in class is carried out properly. Learning media as a means or intermediary tool in order to convey messages in the form of learning. This study aims to determine the needs of students in learning media Shorof. Where the effective media is the media according to the needs of students. The researcher uses the R&D method with a 4D Thiagarajan model in this study which consists of defining, planning, developing and disseminating. In collecting data, the researchers conducted observations and gave questionnaires to students' media needs. The average results show that students need learning media that can be accessed at any time to increase enthusiasm for learning in class VIII A with a percentage value of 79.00% (Required) and class VIII B with a percentage value of 83.00% (Required). The results of the percentage value state that students need an Android-based ispring suite learning media on shorof subjects because it can be accessed anytime.
Prevalence of Allergy Symptoms in Schoolchildren of Chechen Republic (ISAAC Questionnaire Results)
Authors: Ibisheva Aset Kh. , Idrisov Alikhan A. , Mezhidov Kazbek S. , Namazova-Baranova Leila S. 
Published: December 2021

Background. Rising prevalence of allergic diseases is a major medical and social problem.Objective. The aim of the study is to study the prevalence of allergy symptoms in schoolchildren of Chechen Republic according to the ISAAC (International Study of Asthma and Allergy in Childhood) questionnaire.Methods. We have surveyed 3,398 schoolchildren from 26 randomly chosen schools located in 2 urban and 2 rural areas of Chechen Republic. The first age group (7–8 years old) included 1331 first graders, the second group (13-14 years old) — 2067 eighth graders.Results. The prevalence of allergic diseases symptoms according to the questionnaire was the following: bronchial asthma (BA) — 18.4% (625 children), allergic rhinitis (AR) — 16.6% (565 children), atopic dermatitis (AD) — 4.7% (160 children), while medically verified diagnosis was established in dramatically less cases. Analysis of BA, AR, AD symptoms prevalence has revealed significant correlation between studied parameters and age. Symptoms of BA, AR prevailed in the older age group, AD in the younger one. There were no gender differences identified. Higher prevalence of BA and AR symptoms was recorded in urban residents, while the prevalence of AD in urban and rural areas was quite the same. Moreover, estimation of allergy symptoms prevalence revealed mild course of these diseases in schoolchildren of Chechen Republic.Conclusion. The study, conducted with ISAAC questionnaire, demonstrates high prevalence of allergy symptoms in schoolchildren of Chechen Republic, exceeding the official statistics. It requires particular attention from the healthcare system and improved diagnostic methods for allergies.
Articular Syndrome Characteristics in Children with Mucopolysaccharidosis Type I
Authors: Vashakmadze Nato D. , Kostik Mikhail M. , Zhurkova Nataliya V. , Buchinskaia Nataliya V. , Zakharova Ekaterina Yu. , Soloshenko Margarita A. 
Published: December 2021

Background. Mucopolysaccharidosis type I is disease from the group of lysosomal storage disease developing due to mutations in the IDUA gene. It leads to the accumulation of glycosaminoglycans (GAGs) in organs and tissues. Joints damage in this disease is systemic and progressive.Objective. The aim of the study. Nowadays, relevant issue is to investigate the effects of various types of pathogenetic therapy on the state of the osteoarticular system in patients with severe and mild phenotypes of MPS I to prevent further progression of joint pathology.Methods. The study included 46 patients diagnosed with “mucopolysaccharidosis type I”. 35 children had severe phenotype (Hurler syndrome) and 11 — with mild phenotypes (Hurler-Scheie and Scheie syndromes). The onset age of clinical manifestations in osteoarticular system, the state of large and small joints, and the presence of cervical stenosis according to the therapy were evaluated in these patients.Results. The osteoarticular system pathology can be usually revealed in all patients with MPS I, in both mild and severe phenotypes. The contractures of shoulder, ulnar, wrist, and small hand joints have been revealed in most patients with Hurler syndrome, regardless of the administered therapy. Hip joints pathology was observed in children who was administered with: enzyme replacement therapy (ERT) — in 46.7% of cases, hematopoietic stem cell transplantation (HSCT) in combination with ERT — in 34.4% of cases. Patients with Hurler syndrome administered with HSCT in combination with ERT had cervical stenosis statistically significantly more rarely (p = 0.018) compared to patients treated with ERT only. Patients with Hurler syndrome who were on ERT had statistically significantly lower growth rates than patients after HSCT in combination with ERT. Lesions in ulnar, wrist, knee and small hand joints were the most common in children with mild phenotypes (in 90% of cases).Conclusion. Combined therapy (HSCT and ERT) in patients with Hurler syndrome reduces severe manifestations in osteoarticular system, including children with a pathogenic nucleotide variant c.208C>T in a homozygous state.