bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of Virtual Reality to Parent-Child Interaction Therapy for Enhancement of Positive Parenting Skills: The Study Protocol
Authors: Scherpbier Iza C.A. , Abrahamse Mariëlle E. , Belleman Robert G. , Popma Arne , Lindauer Ramón J.L. 
Published: August 2021

Abstract
Background: Disruptive behaviour is a common reason that young children are referred to child and adolescent mental health care services worldwide. Research indicates that treatments for child disruptive behaviour where parents are the primary agents of change are most impactful. Parent-Child Interaction Therapy (PCIT) is an effective parent management training program, currently implemented in therapeutic settings within the Netherlands. If parenting skills have been mastered, PCIT has shown to make impactful long-term improvements on parental warmth, responsiveness and effectiveness. The current study aims to increase the proven effectiveness of PCIT by increasing accessibility and impact of the treatment with a focus on strengthening positive parenting skills. To enhance the skills from the therapy, the current study will implement a Virtual Reality (VR) element for additional practice in the home-setting. We expect that if the positive parenting skills are trained by implementing the VR-element, skill mastery will be achieved sooner, treatment completion rates will increase and the parent-child relationship will better, whilst parental stress and child disruptive behaviour will decrease.Methods: Fifteen children (ages 2 to 7 years old) with disruptive behaviour and their parents will followed throughout their PCIT-VR treatment. Using a non-concurrent multiple baseline Single-Case Experimental Design (SCED) with three phases, fifteen families will fill out questionnaires weekly, in addition to having pre-, and post-treatment and follow-up measurements to monitor their positive parenting skills, child disruptive behaviour, parenting stress and VR progress. Moreover, the quantitative information and qualitative interviews will be analysed visually and statistically and summarised to provide a complete picture of experiences from both parents and therapists. Discussion: The SCED - with its phased design, randomisation and the opportunity to replicate and assess both individual and group treatment effects - and adaptability of the VR technology are the strengths of the study. The risks of increased type I errors, maturation effects or technological failure will be mitigated with the right statistical support. The current study aims to enhance the scope of the treatment through the additional skill training, ultimately in support of routinely implementing VR at scale within PCIT.
In Vitro Mass Micropropagation of Mammillaria Vetula ssp. Gracilis var. Arizonica Snowcap
Authors: Lopez-Granero López Granero M. Manuel , Arana Antonio , González Jose Javier Regalado , Encina Carlos Lopez 
Published: August 2021

Abstract
A mass micropropagation method was developed for Mammillaria vetula ssp. gracilis cv. Arizonica Snowcap, a cactus species with high ornamental value. A culture media based in MS medium (Murashige and Skoog, 1962) supplemented with 0.1 mg l− 1 NAA + 0.3 mg l− 1 KIN + 5.0 mg l− 1 GA3 + 30 g l− 1 sucrose (MSM-1), was developed specifically for the establishment and multiplication of Mammillaria vetula cv. Snowcap offshoots, let us to produce a proliferation rate of 34.9 ± 5.9 new offshoots per explant. The non-rooted offshoots were rooted in MSM-2, consisting in MS salts supplemented with 0.1 mg l− 1 NAA + 0.3 mg l− 1 KIN plus 5 mg l− 1 ancymidol and a lower dose (10 g l− 1) of sucrose, with a rooting rate of 100%. The rate of acclimatization of the rooted offshoots was 100%. The full process of micropropagation from aseptic establishment in vitro to the end of plant acclimation takes approximately between 5 and 6 months and the plant production can be maintained continuously during all year.
Gastric Adenocarcinoma With Signet Ring Cell: A Case Report of a 10-year-old Girl.
Authors: Arcila Jose Andres Tascon , Gomez Lizeth Marín , Rodas Luisa María Parra , Ospina Gustavo Giraldo , Luna Alejandra Wilches , Muñoz María Rosmira Pérez 
Published: August 2021

Abstract
BackgroundGastric cancer is an extremely rare diagnosis in children and adolescents. Representing 5% of neoplasia’s in childhood. Gastric adenocarcinoma has a prevalence of below 0.05% of all childhood cancers. The objective of this clinical case report is to describe the clinical presentation of this rare cancer in children, including it as a differential diagnosis, and to look for genetic causes in order to perform genetic counseling. Case presentationA 10 year old girl, experience epigastric pain, vomit and weight loss in 2 months period. Previously treated with proton pump inhibitors (PPIs), however without improvement of symptoms. Physical exam revealed a slim appearance, and a firm, painful, palpable mass in the upper abdomen. Esophagogastroduodenoscopy revealed a mass with neoplastic appearance. Biopsy report described a poorly differentiated, diffuse pattern of signet ring cells, with positive immunohistochemical studies for the expression of MLH1, MSH6; PMS2. H. pylori was negative. Because this cancer presented during childhood, CDH1 gene was analyzed, however no findings of pathologic variants, point mutations, or duplications or deletions were found. The patient underwent hospice care and died 7 months after the initial diagnosis.Discussion/ConclusionThe majority of gastric tumors during childhood are benign. Gastric adenocarcinoma is a rare diagnosis in pediatric patients. Currently, there are few reports of children with this cancer. The rarity of gastric adenocarcinoma with signet ring cells in pediatric patients makes early diagnosis difficult to make with treatment options limited to the pediatric population due to rarity, and worse prognosis. Knowledge of this disease in children could help physicians to identify atypical clinical manifestations and warning signs in order to have this as a differential diagnosis. Currently, genetic studies are essential to guide the treatment plan and to make genetic counseling to the patient and family members.
The Association Between Trichomonas Vaginalis Infection and the Risk of Benign Prostate Hyperplasia, Prostate Cancer, and Bladder Cancer in Patients: a Nationwide Population-based Case-control Study
Authors: Yang Hung Yi , Su Ruei-Yu , Chung Chi-Hsiang , Lin Hsin-Chung , Huang Kuo-Yang , Chien Wu-Chien , Chen Chien-Chou 
Published: August 2021

Abstract
Background: Trichomonas vaginalis infection is one of the most widespread sexually transmitted infections in the world. There are approximately 276 million cases worldwide. Most men remain undiagnosed and untreated because they are asymptomatic. The chronic inflammation induced by persistent infection may increase the risk of developing genitourinary cancers. In this study, we aimed to investigate the association between trichomoniasis and benign prostate hyperplasia (BPH), prostate cancer (PCa), and bladder cancer (BC) in Taiwan.Material and method: We designed a case-control study by using the database of the National Health Insurance program in Taiwan. We used the International Classification of Diseases, 9th Revision classifications to classify all the medical conditions in the case and control groups. All odds ratios (ORs) and 95% confidence intervals (CIs) were analyzed using multivariable logistic regression to adjust for all comorbidities and variables.Result: From 2000 to 2015, we enrolled a total of 62,544 individuals as the case group and 187,632 as the control group. Trichomoniasis exposure had a significant association with BPH and PCa (adjusted OR: BPH = 2.685, 95% CI = 1.233–4.286, P = 0.013; PCa = 5.801, 95% CI = 1.296–26.035, P = 0.016). The relative risk was much higher if patients had both trichomoniasis and depression (adjusted OR = 7.682, 95% CI = 5.730–9.451, P < 0.001).Conclusion: Men with trichomoniasis had a significantly higher risk of developing BPH and PCa than those without. Healthcare professionals should not only pay more attention to disease treatment, but also to public health education.
Development of a Clinical Nomogram for Prediction of Response to Neoadjuvant Chemotherapy in Patients with Advanced Gastric Cancer
Authors: Liang Xianwen , Liao Xu-Liang , Pang Hua-Yang , Pan Tao , Song Xiao-Hai , Zhang Wei-Han , Liu Kai , Chen Xiao-Long , Chen Xin-Zu , Yang Kun , Hu Jian-Kun 
Published: August 2021

Abstract
Objective:The efficacy of neoadjuvant chemotherapy (NAC) among advanced gastric cancer (GC) is still a controversial issue. Our aim is to find the factors associated with chemosensitivity of NAC, and provide optimal therapeutic strategy for GC patients who received NAC.Methods: Clinical information was collected from 230 gastric cancer patients who received NAC in West China Hospital from January 2016 to December 2020. LASSO logistic regression analysis was performed to find the possible predictors which a nomogram model for prediction of response to NAC was based on.Results: A total of 230 patients were finally included in this study, including 154 males (67.0%) and 76 females (33.0%). And mean age was (59.37±10.60) years, ranging from 24 to 80 years. Based on the TRG standard, there were 95 cases in the obvious response group (grade 0 or grade 1) and 135 cases in the non-obvious response group (grade 2 or grade 3), and the obvious response rate was 41.3%. LASSO analysis showed that four risk factors that were significantly related to the efficacy of NAC, which included tumor location (P<0.001) , histological differentiation (P=0.001), clinical T stage (P=0.008) , CA724 (P=0.008) . The C-index for prediction nomogram was 0.806, and the calibration curve revealed the predicted value exhibited good agreement with the actual value, decision curve analysis showed that the nomogram had a good value in clinical application.Conclusions: The nomogram which combined tumor location, histological differentiation，clinical T stage and CA724 showed satisfactory predictive power to response of NAC, and could be used by gastrointestinal surgeons to identify optimal treatment strategy for advanced gastric cancer patients.
BRAF V600E-Mutant Colorectal Cancers with Liver-Only Metastases: A Retrospective Study.
Authors: Javed Sahir , Benoist Stéphane , Devos Patrick , Truant Stéphanie , Guimbaud Rosine , Lièvre Astrid , Sefrioui David , Cohen Romain , Artru Pascal , Dupré Aurélien , Bachet Jean-Baptiste , Fourchardière Christelle de la , Ploquin Anne , Turpin Anthony 
Published: August 2021

Abstract
BACKGROUND BRAF V600E-mutant colorectal cancers (CRCs) are associated with shorter survival than BRAF wild-type tumors. Therapeutic decision-making for colorectal liver metastases (CRLM) harboring this mutation remains difficult due to the scarce literature. Our aim was to study a large cohort of BRAF V600E-mutant CRLM patients in order to identify prognostic factors associated with overall survival. METHODS We retrospectively identified BRAF V600E-mutant CRCs diagnosed with liver-only metastases, resected or not, between April 2008 and December 2017, in 25 French centers. Clinical, molecular, pathological characteristics and treatment features were collected. Overall survival (OS) was defined as the time from CRLM diagnosis to death from any cause. Cox proportional hazard models were used for statistical analysis. RESULTSAmong the 105 patients included, 79 (75%) received chemotherapy, 18 (17%) underwent upfront CRLM surgery, and 8 (8%) received exclusive best supportive care. CRLM surgery was performed in 49 (46.7%) patients. CRLM were mainly synchronous (90%) with bilobar presentation (61%). The median OS was 34 months (range, 28.9–67.3 months) for resected patients and 10.6 (6.7–12.5) months for unresected patients (P < 0.0001). Most patients received doublet chemotherapy (72%), and 34% received a combination with bevacizumab as a first-line treatment. In multivariate analysis, primary tumor surgery (hazard ratio (HR) = 0.349; 95% confidence interval (CI) 0.164–0.744, P = 0.0064) and CRLM resection (HR = 0.169; 95% CI 0.082–0.348, P < 0.0001) were associated with significantly better OS. CONCLUSIONSIn the era of systemic cytotoxic chemotherapies, liver surgery seems to extend OS. Therefore, CRLM resectability should be assessed, regardless of mutational status.
Comprehensive Analysis of the Prognosis for Chemokine-Like Factor MARVEL Transmembrane Domain-Containing Family in Hepatocellular Carcinoma
Authors: Li Dan , Huang Shenglan , Sun Liying , Wu Jianbing 
Published: August 2021

Abstract
Background and Purpose: Chemokine-like factor (CKLF) MARVEL transmembrane domain-containing family (CMTMs), including chemokine-like factor (CKLF) and CMTM1 to CMTM8. All of these genes participate in tumor development and metastasis of hepatocellular carcinoma (HCC). However, prognosis values and the distinct roles of different CMTMs in HCC are still un-clarified.Materials and Methods: To address this issue, the study explored the function of CMTM family members in the prognosis of HCC by TCGA dataset, UALCAN, Kaplan-Meier Plotter, MethSurv, TIMER2.0 databases.Results: The CKLF and CMTM1/3/4/7/8 mRNA expression was obviously elevated in HCC tissues, while CMTM2/5/6 was lowly expressed. Besides, the mRNA level of CMTMs was closely linked to cancer stage, node metastasis status and tumor grades in HCC patients. What’s more, the expression of CMTM2/5 was correlated with favorable overall survival (OS), while high expressions CKLF and CMTM1/7 were associated with poor OS. Simultaneously, low CKLF and CMTM1/4/7 expressions were significantly relevant to better progression-free survival (PFS), while low CMTM5 expression was apparently concerned with worse PFS. In DNA methylation level, 47 CpGs of CMTMs displayed markedly prognostic values. Multivariate cox analysis also revealed that affecting shorter OS outcomes prognostic factors of CKLF and CMTM7 were independent. GSEA results suggested that CKLF and CMTM7 participated in the development and progression of HCC accompanied with multiple biological processes. Furthermore, CMTMs were dramatically associated with tumor immune infiltrating cells (TIICs) (e.g., neutrophils cells), but CMTM8 expression level was no significant correlations with TIICs.Conclusion: This study renders new insight into the prognostic values of CMTM family members in HCC. Overall, our results indicated that CKLF and CMTM7 could be the prognostic biomarkers in HCC patients.
The Assessment of Potential Observability for Joint Chemical States and Emissions in Atmospheric Modelings
Authors: Wu Xueran , Elbern Hendrik , Jacob Birgit 
Published: August 2021

Abstract
In predictive geophysical model systems, uncertain initial values and model parameters jointly influence the temporal evolution of the system. As for chemistry-transport models, emission rates are at least as important as initial values for model evolution controls. This renders initial-value-only optimization by traditional data assimilation methods as insufficient. However, blindly extending the optimization parameter set jeopardizes the validity of the resulting analysis since the ill-posedness of the inversion task is increased. Hence, it becomes important to assess the potential observability of measurement networks for model state and parameters in atmospheric modelings in advance of the optimization. In this paper, we introduce an approach to quantify the impact of observation networks jointly for initial trace gas state and emission rates for transport-diffusion models extended by emissions. Applying a Kalman smoother as underlying assimilation technique, we develop a quantitative assessment method to evaluate the potential observability and the sensitivity of observation networks to initial values and emission rates. For practical applications, we derive an ensemble based version of the approach and give several elementary experiments for illustration.
Sociodemographic Disparities in the Establishment of Health Records Among 0.5 Million Migrants From 2014 to 2017 in China: a Nationwide Cross-sectional Study
Authors: Wang Jun , Zhu Jingmin , Wang Xueyao , Che Yue , Bai Yang , Liu Jue 
Published: August 2021

Abstract
Background: Migrants account for a large part of China’s population. Many policies and inventions have been taken to improve access to public health services and the health of migrants. China’s Basic Public Health Services（BPHS) are a series of public health services in this policy domain, which aims at promoting the access of public health sevices and improve health equity of residents.The establishment of health records is the fundamental service of BPHS. However，there is little known about the establishment of health records among migrants in China, which hinders the more efficient provision of health services for migrants, and health equity is difficult to achieve. Based on the research gap, this study aims at showing the sociodemographic disparities in the establishment rate of health records, and identifying priorities and recommendations for promoting health equity of migrants in China.Methods: This study used national data from China Migrants Dynamic Survey(CMDS) from 2014 to 2017 to evaluate the sociodemographic disparities in the establishment rate of health records and utilization of relevant public health services.The study included 539926 respondents. Following the descriptive statistics of migrants, we showed the establishment rate of health records by sociodemographic characteristics and migrating related characteristics. Multivariate analysis was conducted to explore the associations between sociodemographic charicteristics, migrating related charicteristics and the establishment of health records.Results: The establishment rate of health records among migrants in the sampled years were 22.99%, 38.44%, 27.29% respectively, and 29.18% in general, and there existed heterogeneity in the establishment rate of health records by sociodemographic charicteristics and migrating related charicteristics. Female migrants who were older, from middle age, married or living with partner, with higher educational attainment, with urban household registration, migrated for longer time, migrated for the reason of studying or family issues, migrated in province were more likely to establish health records.Conclusion: There existed sociodemographic disparities in the establishment rate of health records and inequalities in the utilization of health records services among migrants in China. Migrating related characteristics also had impact on the establishment status. Policies should take both supply side and demand side of health services to improve the health equity of migrants, which means that relative departments should continue to invest in primary healthcare centers to improve their ability to provide services as well as migrants’ health literacy.
The Effectiveness of Non-pharmacological Treatments for Vestibular and Oculomotor Deficits in Post-concussive Syndrome: a Protocol for a Systematic Review and Meta-analysis
Authors: Sheeba Stella R , Cavaleri Rocco , Summers Simon J , Browne Cherylea J 
Published: August 2021

Abstract
Background: Concussion is a form of mild traumatic brain injury (mTBI) that disrupts brain function. Although symptoms are mostly transient, recovery can be delayed and result in post-concussive syndrome (PCS). Vestibular and oculomotor deficits are among the most debilitating impairments associated with PCS. Non-pharmacological interventions provide treatment with limited side effects in comparison to pharmacological interventions. The aim of this review is to synthesise and evaluate the effectiveness of non-pharmacological interventions that have been used to target vestibular and oculomotor deficits in PCS.Methods: Advanced searches will be conducted in electronic databases to identify articles eligible for inclusion. Studies employing non-pharmacological treatments for vestibular and/or oculomotor dysfunction in PCS will be included if they meet the eligibility criteria. Outcomes will be those pertaining to measures of oculomotor and vestibular function, in addition to adverse events. Meta-analysis will be undertaken using a random effects model followed by an assessment of clinical significance for each outcome as published in literature. Discussion: While non-pharmacological interventions are used commonly to treat vestibular and oculomotor deficits in PCS, the effectiveness of these treatments is yet to be completely elucidated. The present review will explore the effectiveness of non-pharmacological treatments for vestibular and oculomotor deficits in PCS to inform practice and future research.Systematic review registration: PROSPERO CRD42021254720
Thermoplasmonic Effect Onto Toad Physiology Signals by Plasmonic Microchip Structure
Authors: Akbari S. , Hamidi S. M. , Eftekhari H. , Soheilian A. 
Published: August 2021

Abstract
Cardiovascular diseases are considered as the leading cause of death and almost 80% of deaths from this disease are developed in poor and less developed countries where early detection facilities are less available, along with overlooking the importance of screening. In other words, real-time monitoring of the physiological signals using flexible and wearable biosensors plays an important role in human life style. Thus, the present study aims to propose two dimensional flexible and wearable gold covered plasmonic samples as a physiological signal recorder, in which chips with nano array of resonant nanowire patterns performing in an integrated platform of plasmonic devices. The produced surface plasmon waves in our main chip were paired with an electric wave from the heart pulse and it use for recording and detecting the heartbeat of a toad with high accuracy. This measurement was performed in normal state and under external laser heating process to check the ability of signal recording and also thermoplasmonic effect onto the toad's heart signal. Our results show that our sensor was enough sensitive for detection while raising the body temperature of the toad and changing its heart rate as flatting T and P waves by thermoplasmonic effect.
Global CO2 Fertilization of Sphagnum Peat Mosses via Suppression of Photorespiration During the 20th Century
Authors: Serk Henrik , Nilsson Mats , Bohlin Elisabet , Ehlers Ina , Wieloch Thomas , Olid Carolina , Grover Samantha , Kalbitz Karsten , Limpens Juul , Moore Tim , Münchberger Wiebke , Talbot Julie , Wang Xianwei , Knorr Klaus-Holger , Pancotto Verónica , Schleucher Jürgen 
Published: August 2021

Abstract
Natural peatlands contribute significantly to global carbon sequestration and storage of biomass, most of which derives from Sphagnum peat mosses. Atmospheric CO2 levels have increased dramatically during the 20th century, from 280 to > 400 ppm, which has affected plant carbon dynamics. Net carbon assimilation is strongly reduced by photorespiration, a process that depends on the CO2 to O2 ratio. Here we investigate the response of the photorespiration to photosynthesis ratio in Sphagnum mosses to recent CO2 increases by comparing deuterium isotopomers of historical and contemporary Sphagnum tissues collected from 36 peat cores from five continents. Rising CO2 levels generally suppressed photorespiration relative to photosynthesis but the magnitude of suppression depended on the current water table depth. By estimating the changes in water table depth, temperature, and precipitation during the 20th century, we excluded potential effects of these climate parameters on the observed isotopomer responses. Further, we showed that the photorespiration to photosynthesis ratio varied between Sphagnum subgenera, indicating differences in their photosynthetic capacity. The global suppression of photorespiration in Sphagnum suggests an increased net primary production potential in response to the ongoing rise in atmospheric CO2, in particular for mire structures with intermediate water table depths.