bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased Number of Corpora Lutea by Creating Additional Corpus Luteum Leads to Enhanced Progesterone Concentrations and Improved Fertility in Bovine Repeat-breeder Females Undergoing the Short-term Fixed-time Artificial Insemination Protocol
Authors: Pirokad Wilasinee , Yadmak Chayanon , Yama Punnawut , Jitjumnong Jakree , Chaikol Warunya , Sangkate Molarat , Promsao Nalinthip , Sudwan Paiwan , Mektrirat Raktham , Panatuk Julakorn , Intawicha Payungsuk , Lumsangkul Chompunut , Tang Pin-Chi , Moonmanee Tossapol 
Published: August 2021

Abstract
Background: Lower concentrations of endogenous progesterone (P) after fertilization, due to corpus luteum (CL) dysfunction, leads to an increased embryonic loss and reduced pregnancy outcomes not only in female cattle but also in women. Therefore, an increase in the number of corpora lutea (CLs) may improve fertility in infertile bovine females. The aim of the current study was to investigate the influence of increased number of CLs by creating accessory CL on plasma P concentration and fertility in bovine repeat-breeder females undergoing the short-term fixed-time artificial insemination (FTAI) protocol.Methods: In experiment 1, 32 female cattle had induced ovulation with the short-term (5-day) P-based protocol. To induce additional CL, cows were treated with gonadotropin releasing hormone (GnRH) on day 5 post-induction. On day 14, only female cattle with at least one CL on their ovaries were classified into two groups: 1CL (original CL; n = 14) and 2CLs groups (original CL + accessory CL; n = 8). In experiment 2, 213 bovine repeat-breeder females were bred using the short-term FTAI protocol. On day 5 post-FTAI, cows were divided into two groups: treatment with (GnRH5-treated group; n = 113) or without (GnRH5-untreated group; n = 100) GnRH. On day 14 post-FTAI, cows were sub-divided into two groups: 1CL (n = 115) and 2CLs (n = 39) groups.Results: In experiment 1, the ovarian luteal diameter, area, and volume per total CLs were greater in 2CLs group compared with 1CL group (P < 0.001). On days 12 and 14 post-induction, female cattle bearing two CLs had greater P concentrations than female cattle bearing only one CL on their ovaries (P < 0.05). In experiment 2, CL number and pregnancy rates were greater in GnRH5-treated group compared with GnRH5-untreated group (P < 0.01). Pregnancy rates were greater in 2CLs cows compared with 1CL cows (P < 0.01). Moreover, female cattle bearing two CLs had a greater likelihood of pregnancy (odds ratio = 20.86) than female cattle bearing only one CL on their ovaries (P = 0.001). Conclusions: In bovine model, our findings confirmed a beneficial effect of an additional CL on ovarian hormone and fertility in infertile female cattle. The results highlighted that increased number of CLs by creating additional CL leads to enhanced peripheral P concentrations and improved pregnancy outcomes in bovine repeat-breeder females undergoing the short-term FTAI protocol.
Factors that impact acceptance of COVID-19 vaccination in different community-dwelling populations in China
Authors: Pan Jinhua , A Kezhong , Liu Zhixi , Zhang Peng , Xu Zhiyin , Guo Xiaoqin , Liu Guangtao , Xu Ao , Wang Jing , Wang Xinyu , Wang Wei-bing 
Published: August 2021

Abstract
Background
It is important to improve vaccination strategies and immunization programs to achieve herd immunity to infectious diseases, particularly in general community-dwelling populations.
Methods
To assess the acceptance of COVID-19 vaccination, we conducted face-to-face surveys and online surveys in Shanghai, Zhejiang, and Qinghai province. A fixed effects model and a random effects model were used to analyze factors associated with acceptance of COVID-19 vaccination.
Findings
The results indicated that 82·6% of participants (77·0% in Shanghai and 87·3% in Zhejiang) were willing to receive vaccination when it was available in the community, and 57·2% of deliverymen, 43·3% of medical workers, 78·2% of parents of primary and secondary school children, and 72·2% of parents of preschool children were willing to receive vaccination. The models showed that participants who were male, 60 to 69 years-old, from rural areas, had less education, had good health status, and had positive attitudes and trust in vaccines approved by National Health Commission were more likely to accept vaccination. Participants also had increased vaccination acceptance if it was recommended by government sources, doctors, relatives, or friends. Most participants learned about COVID-19 vaccination from television, radio, and newspapers, followed by community or hospital campaigns and the internet. Those who did not want to receive vaccination were mainly concerned about safety (288, 59·6%) and efficacy (196, 40·6%).
Conclusions
Government sources and doctors could increase acceptance of vaccination by promoting the efficacy and safety of COVID-19 vaccination by use of mass media and emphasizing the necessity of vaccination for everyone.
Aminopolycarboxylate Chelators Are Effective for Whole-body Clearance of Free 225ac: A Method to Reduce Unexpected Radiation Exposure During Targeted Alpha Therapy
Authors: Yoshimoto Mitsuyoshi , Yoshii Yukie , Matsumoto Hiroki , Shinada Mitsuhiro , Takahashi Masashi , Igarashi Chika , Hihara Fukiko , Tachibana Tomoko , Doi Ayano , Higashi Tatsuya , Fujii Hirofumi , Washiyama Kohshin 
Published: August 2021

Abstract
Purpose: Actinium-225 (225Ac) is a promising radionuclide used in targeted alpha therapy (TAT). Although 225Ac labelling of bifunctional chelating ligands is effective, previous in vivo studies have reported that free 225Ac can be released from the drugs. Notably, such free 225Ac predominantly accumulates in the liver and can cause unexpected toxicity. To accelerate the clinical development of 225Ac TAT, methods for addressing unexpected toxicity are therefore needed. In this study, we evaluated various chelators in vitro and in vivo with regard to reducing and excreting free 225Ac and compared their chemical structures. Methods: Nine candidate chelators (D-penicillamine, dimercaprol, Ca-DTPA, Ca-EDTA, CyDTA, GEDTA TTHA, Ca-TTHA, and DO3A) were tested. In vitro interaction of 225Ac and chelators was investigated. Biodistribution and dosimetry of free 225Ac were examined in mice prior to the in vivo chelating study. For in vivo chelation, nine candidate chelators were administered 1 h after free 225Ac injection, and biodistribution was compared 4 h after 225Ac injection in mice. Two favourable chelators were then investigated intensively for biodistribution 24 h after the 225Ac injection.Results: The liver exhibited pronounced 225Ac uptake corresponding to an estimated human absorbed dose of 4.76 SvRBE5/MBq. Aminopolycarboxylate chelators with five and six carboxylic groups, Ca-DTPA and Ca-TTHA, significantly reduced 225Ac retention in the liver (22% and 30%, respectively). Significant 225Ac reductions were observed in the heart and the remainder of the body with both Ca-DTPA and Ca-TTHA, and in the lung, kidney, and spleen for Ca-TTHA. In vitro interaction analysis supported the in vivo reduction ability of Ca-DTPA and Ca-TTHA.Conclusions. Aminopolycarboxylate chelators with five and six carboxylic groups, Ca-DTPA and Ca-TTHA, were effective for whole-body clearance of free 225Ac, with a significant reduction in the liver. This method could reduce undesirable radiation exposure from free 225Ac during 225Ac TAT.
Incidence of Adverse Drug Reactions in Two Tertiary Hospitals: A Prospective Observational Study
Authors: Khalili Malahat , Sharifi Hamid , Mesgarpour Bita , Dabaghzadeh Fatemeh , Haghdoost Ali Akbar 
Published: August 2021

Abstract
Background: Monitoring and detecting adverse drug reactions (ADRs) in hospitals is crucial to improving drug safety and healthcare delivery quality. Nevertheless, there was not enough information on ADR incidence and its figure in Iran. Aim: this study aimed to determine the incidence of ADRs in hospitalized patients and investigate their characteristics in Iran.Methods: We conducted a three-month prospective study in two tertiary hospitals in 2019. All admitted patients were intensively monitored for all suspected ADRs through daily visiting hospital wards and soliciting information from physicians, nurses and interviewing suspicious patients. We calculated the incidence of ADRs, and 95% confidence intervals (95% CI). Poisson regression was used to evaluate risk factors for ADR incidence. Results: Among 13,613 admitted patients, we detected 115 ADRs in 114 patients. The incidence of ADR was 8.4 per 1000 admissions (95% CI: 7.0-10.1), and 13.9% of them were ADR-related hospital admissions. The risk of ADRs was significantly predicted by age, length of hospital stay, patients’ diagnostics, number of drug usage, and using respiratory system agents and anti-infectives for systemic use. The most common ADRs were skin and subcutaneous manifestations (52.2%), and 62.6% of ADRs were caused by anti-infectives (commonly vancomycin, ceftriaxone, and ciprofloxacin). Conclusion: This study indicated that ADRs occurrence during the hospital stay or resulting in hospital admissions are considerable. Given that ADR occurrence could be associated with increased morbidity, mortality, and economic burden, constant intensive monitoring is required to address the drug safety issue and promote actions to improve patient safety and reduce the health and economic burden.
The Results of Conversion Therapy for Initially Unresectable Gastric Cancer: a Respective Analysis of 191 Patients
Authors: Zhang Shaopeng , Wu Song , Kong Yuan , Li Wei 
Published: August 2021

Abstract
【Objective】

To analyze the clinical efficacy of systemic chemotherapy combined with intraperitoneal hyperthermic perfusion in the treatment of locally invasive stage III gastric cancer and stage IV gastric cancer.

【Methods】

The clinical data of 191 patients with gastric cancer who received systemic chemotherapy combined with intraperitoneal hyperthermic perfusion from June 2010 to December 2018 were retrospectively analyzed.

【Results】

The unresectable factors in 191 patients with gastric cancer included peritoneum metastasis (106), local invasion (67), liver metastasis (25), lung metastasis (3), bone metastasis (4), adnexal metastasis (3) and adrenal metastasis (4). After conversion therapy, 191 patients were divided into finished conversion group and non-finished group. There were significant differences in T stage, M stage and tumor differentiation between the two groups. During the course of chemotherapy, 11 patients had grade 3 or 4 chemotherapy adverse reactions. The median survival was 36 months in the finished conversion group and 14 months in the non-finished group. The median survival of the 69 R0 resected patients was 38 months, which was higher than that of chemotherapy alone (14 months), best supportive care (13 months) and patients who completed chemotherapy without R0 resection (19 months). Univariate Cox survival analysis found that N stage, R0 resection, response to chemotherapy and unresectable factors were prognostic factors. Multivariate Cox survival analysis showed that N-stage, response to chemotherapy and unresectable factors were independent prognostic factors.

【 Conclusion 】 For unresectable gastric cancer patients, surgical treatment after chemotherapy can prolong survival. Radical surgical treatment after conversion therapy and chemotherapy response are important factors related to patient survival. Chemotherapy alone can prolong survival in primary unresectable gastric cancer, but with limited effect.
A case of Brucellosis with Large Periaortic Mass And Secondary Vasculitis In A Patient Presenting Intermittent Abdominal Pain
Authors: Liu Huilan , Zhang Yutong , Leng Xiaomei , Yang Yunjiao , Zeng Xiaofeng 
Published: August 2021

Abstract
Background Brucellosis is still highly prevalent and causes high morbidity. It can involve any organ system and has been implicated in protean complications. Cardiovascular involvement is the main cause of mortality. This case described a female patient infected by Brucella with large periaortic mass and secondary vasculitis whose manifestation was abdominal pain. The aim was to raise the awareness of earlier recognition of Brucella infections without fever and remitting risk by taking appropriate treatments for those with cardiovascular involvement.Case presentation A case was reported regarding a female present intermittent abdominal pain. Two months later, she was admitted to the Department of Rheumatology and Immunology in our hospital due to high inflammatory markers, the large periaortic mass and vasculitis manifestations in aortic computed tomography angiography. By detailed examination, Brucellosis was highly suggestive based on positive blood cultures. Finally, no discomfort has ever occurred, and the mass was prominently reduced after antibiotic therapy of half a year.Conclusions The clinical manifestations of brucellosis are protean. For those without fever and cardiovascular involvement as the main manifestation, especially vasculitis, we must not just set the standard rigidly, instead, it is recommended to carry out the relevant differential diagnosis to avoid misdiagnosis or missed diagnosis.
Exploring Medical Response Preparation Strategies for Terrorist Subway Dirty Bomb Explosion Based on A Simulation System
Authors: Yan Tiecheng , Yang Yuxuan , Yu Min 
Published: August 2021

Abstract
Introduction: London bombings on July 7, 2005 presented serious difficulties for medical response, moreover, if a dirty bomb attack had occurred in an underground train, it would have been more difficulties to cope with. Based on this possibility, it is critical to take strategies on medical response to dirty bomb attacks in underground transport systems into account beforehand. Method: In the Windows 10 operating system, visual studio 2019 environment, we used C ++ language to develop a system that can simulate the process of nuclear or radiological emergency medical rescue based on discrete event simulation, mainly considering the designs of professional rescue groups, staffs’ energy consumption, injured and uninjured persons on site, and competence value of key staffs.Results: In the scenario of a subway dirty bomb terrorist attack causing 2.6 casualties per minute and 208 casualties in total, the manpower needed for the emergency medical response were 5 pre-triage groups, 7 contamination triage groups, 23 decontamination groups, 5 first-aid groups, and 12 comprehensive treatment groups. Besides, 5 first-aid groups and 45 decontamination groups were added to implement on-site rescue. The total number of actual participants in the medical response should be about 337. More than 337 PPE should be prepared.Conclusion: We designed and constructed a simulation system, and used it to explore the medical response preparation strategies for subway terrorist dirty bomb explosion, including preparation of sufficient staffs and equipment, consideration of the rotation needs of the staffs, and perception of real-time situation on site and agile command, especially obtained the prediction method of staff and equipment resources for specific disaster background, which could provide constructive references for the security protection of urban subway systems in the future.
Performance of Sustainable Self-Compacting Fiber Reinforced Concrete with Substitution of Marble Waste (MW) and Coconut fibers (CFs)
Authors: Ahmad jawad , Aslam Fahad 
Published: August 2021

Abstract
Self compacting concrete (SSC) is also brittle nature, resulting in abrupt failure without giving any warning, which is unacceptable for any construction materials. Therefore, SCC requires tensile reinforcement to increase tensile capacity and avoid the undesirable brittle failure of SCC. However, fiber improved tensile capacity more efficiently than compressive strength. Therefore, it important add pozzolanic material to fiber reinforced concrete to obtain high strength, durable and ductile concrete. This research is carried out to evaluate the qualities of concrete with addition of waste marble and coconut fiber in concrete. Marble waste used as binding (pozzolanic) materials in proportion of 5.0 to 30% by weight of cement in increment of 5.0% and concrete is reinforced with coconut fiber in proportion of 0.5% to 3.0% by weight of cement in increment of 0.5 %. Rheological properties were assessed through its passing ability and flowability by using Slump flow, Slump T50, L-Box, and V-funnel tests while mechanical performance were evaluated through compressive, split tensile, flexure and pull out tests. Tests results indicate that marble waste and coconut fiber decrease the passing ability and filling ability of SCC. Furthermore, tests results indicate that marble waste up to 20% and coconut fiber addition 2.0% by weight of cement have a tendency to enhance the mechanical strength of SCC. Finally, Statistical analysis (RSM) was used to optimize the combined substitution of marble waste and coconut fiber to obtain high strength concrete.
Microbial profile in infectious keratitis over 8 years in Sao Paulo, Brazil: pathogens and microbial resistance
Authors: de Oliveira Luiza Manhezi Shin , Tanaka Tatiana , Kato Juliana Mika , Shiotuki Regina Sayuri Yamashiro , Corrêa Karoline de Lemes Giuntini , Gioia Thaís Sabato di , Rossi Flavia , Santo Ruth Miyuki 
Published: August 2021

Abstract
Objective

Infectious keratitis remains a sight-threatening disease and its prompt diagnosis and treatment are critical. This study investigated the microbiological patterns of isolates in corneal ulcers in a tertiary health center in an 8-year period.
Methods

Retrospective analysis of scrapes of microbial keratitis performed from January 2013 to December 2020. Demographics and microbiological data were collected.
Results

A total of 446 scrapes were performed on eyes of 433 patients, 270 male (62.4%), mean age 51.7 years. 304 organisms were isolated from 248 (55.6%) positive samples. Polymicrobial infections occurred in 47 samples (19.0%). Bacterial isolates represented 86.8%: 53.3% gram-positive (GP), 33.5% gram-negative (GN). Cutibacterium acnes (12.2%) and Pseudomonas aeruginosa (9.9%) were the most common bacteria. Fungal keratitis comprised 11.8% of the isolates; Fusarium sp (6.2%) was the main fungus isolated. GP tested were sensitive to vancomycin, 98.7% of the GN were sensitive to ceftazidime. All Pseudomonas aeruginosa were sensitive to gentamicin and ciprofloxacin.
Conclusion

Gram-positive bacteria were predominant in keratitis isolates. In severe bacterial keratitis in our area, vancomycin should be considered as empirical treatment.
­­­Bilateral Reduction of Corneal Sub-basal Nerves in Eyes with Recurrent Unilateral Posner-Schlossman Syndrome: An In Vivo Laser Scanning Confocal Microscopy Study
Authors: Huang Ruiping , Tan Li , Xie Xiaoling , Ng Tsz Kin , Huang Chukai 
Published: August 2021

Abstract
PURPOSE. To evaluate the circumstances of corneal sub-basal nerves (CSNs) in the affected and contralateral unaffected eyes of patients with unilateral Posner-Schlossman Syndrome (PSS) through in vivo laser scanning confocal microscopy (LSCM) analysis. METHODS. Total 74 eyes from 37 unilateral PSS patients and 38 eyes of control subjects were recruited. Sub-basal corneal nerve parameters in the in vivo LSCM, including the number and density of total nerves, main nerve trunks, and nerve branches were evaluated. Corneal epithelial and endothelial cell densities were also calculated.RESULTS. The affected eyes of the patients with unilateral PSS demonstrated a significant decrease in all CSN parameters (P<0.005), including the number and density of total nerves, main nerve trunks and nerve branches, as compared to the control eyes. Lower CSN value was observed in contralateral unaffected eyes for total nerve density as well as the number and density of main nerve trunks (P<0.03) as compared to the control eyes. Moreover, corneal endothelial cell density was significantly reduced in affected eyes with PSS as compared to the control eyes (P<0.015). Yet, significant reduction could only be observed in the affected and contralateral unaffected eyes of the patients with recurrent unilateral PSS. In addition, a positive correlation was found between endothelial cell density and the density of main nerve trunks in PSS-affected eyes (r = 0.33, P<0.05).CONCLUSIONS. In vivo LSCM analysis revealed the reduction of CSNs in the affected and contralateral unaffected eyes of the patients with recurrent unilateral PSS. The positive correlation between corneal endothelial cell density and CSNs could suggest a potential link between corneal innervation and corneal endothelial cells.Retrospectively registered ChiCTR2000037630, August 29, 2020
Decoupling of regional neural activity and inter-regional functional connectivity in Alzheimer’s Disease – a simultaneous PET/MRI study
Authors: Balajoo Somayeh Maleki , Rahmani Farzaneh , Khosrowabadi Reza , Meng Chun , Eickhoff Simon B. , Grimmer Timo , Zarei Mojtaba , Drzezga Alexander , Sorg Christian , Tahmasian Masoud 
Published: August 2021

Abstract
Purpose: Alzheimer’s disease (AD) and mild cognitive impairment (MCI), a syndrome at-risk for AD, are characterized by both aberrant regional neural activity and disrupted inter-regional functional connectivity (FC). It is, however, not clear how aberrant regional neural activity and inter-regional FC interact across MCI and AD. Thus, we investigated the interplay between regional neural activity and inter-regional topological measures of FC in MCI and AD using simultaneous PET/MR measurement.Methods: We scanned 19 patients with MCI, 33 patients with AD, and 26 healthy individuals by simultaneous FDG-PET/resting-state fMRI. First, we assessed regional glucose metabolism identified through FDG-PET (as a proxy of regional neural activity), and inter-regional FC topology through clustering coefficient and degree centrality (as surrogates of local segregation and global connectivity, respectively, based on fMRI blood oxygenation). Next, we examined the potential moderating effect of disease status (MCI or AD) on the link between regional metabolism and inter-regional FC topology using hierarchical moderated multiple regression analysis.Results: Not only regional metabolism and inter-regional FC metrics were disrupted in in MCI and AD patients, but also AD significantly alters coupling between regional metabolism and inter-regional FC, particularly in the right inferior temporal, supplementary motor area and planum temporal areas, where AD moderated the effect of their regional glucose metabolism on predicting their inter-reginal FC. Conclusion: Our findings demonstrated that AD decouples the association between regional neural activity and functional segregation.