bluuebunny/crossref_metadata_2025_split huggingface dataset:
Las categorías sexo y género ante la paridad constitucional. Respuesta a Micaela AlterioThe categories sex and gender before electoral parity. A reply to Micaela Alterio
Authors: Torres Díaz María Concepción 
Published: October 2021

Abstract
The article reflects on the concept of gender parity from a critical perspective, taking as reference the normative and conceptual differences of the sex and gender categories as analytical legal categories. It advocates the reinforcement of sex as a central constitutional category for the equality of women and men, and as a democratic requirement that implies the recognition of human mixedness and the socio / sexual subordination of women. It advocates breaking with the corporeal and socio-sexual abstraction of the normative model of the human in order to ensure that sex is not legally irrelevant and argues for the requirement of constitutional parity without further qualifications.
A circular RNA derived from FAT atypical cadherin 3 promotes lung cancer progression via forming a regulatory loop with oncogenic ELAV like RNA binding protein 1
Authors: Jiang Hongfang , Tian Ye , Zhao Xitong , Zhang Lei , Wu Zhuo 
Published: October 2021

Abstract
Circular RNA (circRNA) is a covalently closed endogenous RNA that participates in disease progression. However, its role in lung cancer is largely undetermined. In the present study, we found an onctogenic circRNA in lung cancer, FAT atypical cadherin 3 (FAT3) circRNA (circ-FAT3) was remarkably upregulated in lung cancer in comparison to paired normal tissues. High circ-FAT3 was closely linked to larger tumour size, lymph node metastasis, later clinical stage, as well as dismal outcome. Stable knockdown of circ-FAT3 inhibited cell proliferation and metastasis both in vitro and in vivo. RNA binding protein ELAV like RNA binding protein 1 (HuR) was found to bind to introns flanking circ-FAT3, promoting the cyclization and generation of circ-FAT3. Further, circ-FAT3 was able to sponge miR-136-5p by acting as a competing endogenous RNA (ceRNA), alleviating the repressive effect of miR-136-5p on HuR mRNA at the transcriptional and post-transcriptional levels. Moreover, circ-FAT3 expression in lung cancer tissues was strongly positively and negatively correlated with HuR and miR-136-5p expression, respectively. Overall, our data reveal the previously uncharacterized regulatory loop of circ-FAT3/miR-136-5p/HuR in lung cancer and provide novel evidence for the importance of circRNA as a ceRNA in tumorigenesis.
Characterization ofStreptomycessp. LS462 with high productivity of echinomycin, a potent antituberculosis and synergistic antifungal antibiotic
Authors: Chen Caixia , Chen Xiangyin , Ren Biao , Guo Hui , Abdel-Mageed Wael M , Liu Xueting , Song Fuhang , Zhang Lixin 
Published: October 2021

AbstractA biologically active microbial strain, designated as “LS462,” was isolated from a soil sample collected from Yaoli Virgin Forest of Jiangxi Province, China. The strain was able to produce a high yield of echinomycin (172 mg/l) even under nonoptimized culture conditions and is proposed to serve as a promising source of echinomycin. In this study, echinomycin exhibited strong anti-Mycobacterium tuberculosis H37Rv activity and synergistic antifungal effect with a greatly reduced dosage of posaconazole on Candida albicans SC5314. The strain belongs to the genus Streptomyces according to its morphological and 16S rDNA phylogenetic analysis. The 16S rDNA was found to have the highest sequence identity with Streptomyces fuscichromogenes (99.37% similarity). Extensive nuclear magnetic resonance and mass spectroscopic data were used to determine the structure of echinomycin. The strain S. fuscichromogenes has not been previously reported to produce echinomycin. Strain LS462 may be exploited as a new potential source for the commercial production of echinomycin. Also, this work is the first to report the new synergistic antifungal activity of echinomycin and further study of the synergistic mechanism will be helpful to guide the development of antifungal agents.
Opening a Conversation on Open Communication Research
Authors: Shaw Adrienne , Scharkow Michael , Wang Zheng Joyce 
Published: October 2021

Abstract
Many disciplines have been debating and enacting a range of policies, procedures, and practices that fall under the umbrella term “open research” or “open science.” Following the publication of “An Agenda for Open Science in Communication”, we invited communication scholars to continue the conversation on what open research practices broadly might mean for our diverse field. Specifically, we sought work that: looked empirically at the need for and impact of open research practices; considered the unintended consequences of calls for open research practices broadly; and that reflected on what such a move would mean for qualitative and humanistic communication research. We hope the collection of articles in this special issue motivates and facilitates an ongoing conversation on open research practices in the field of communication.
The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials
Authors: Harding Simon D , Armstrong Jane F , Faccenda Elena , Southan Christopher , Alexander Stephen P H , Davenport Anthony P , Pawson Adam J , Spedding Michael , Davies Jamie A ,   NC-IUPHAR
Published: October 2021

Abstract
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; www.guidetopharmacology.org) is an open-access, expert-curated database of molecular interactions between ligands and their targets. We describe expansion in content over nine database releases made during the last two years, which has focussed on three main areas of infection. The COVID-19 pandemic continues to have a major impact on health worldwide. GtoPdb has sought to support the wider research community to understand the pharmacology of emerging drug targets for SARS-CoV-2 as well as potential targets in the host to block viral entry and reduce the adverse effects of infection in patients with COVID-19. We describe how the database rapidly evolved to include a new family of Coronavirus proteins. Malaria remains a global threat to half the population of the world. Our database content continues to be enhanced through our collaboration with Medicines for Malaria Venture (MMV) on the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY (www.guidetomalariapharmacology.org). Antibiotic resistance is also a growing threat to global health. In response, we have extended our coverage of antibacterials in partnership with AntibioticDB.
dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications
Authors: Li Zhongyan , Li Shangfu , Luo Mengqi , Jhong Jhih-Hua , Li Wenshuo , Yao Lantian , Pang Yuxuan , Wang Zhuo , Wang Rulan , Ma Renfei , Yu Jinhan , Huang Yuqi , Zhu Xiaoning , Cheng Qifan , Feng Hexiang , Zhang Jiahong , Wang Chunxuan , Hsu Justin Bo-Kai , Chang Wen-Chi , Wei Feng-Xiang , Huang Hsien-Da , Lee Tzong-Yi 
Published: October 2021

AbstractProtein post-translational modifications (PTMs) play an important role in different cellular processes. In view of the importance of PTMs in cellular functions and the massive data accumulated by the rapid development of mass spectrometry (MS)-based proteomics, this paper presents an update of dbPTM with over 2 777 000 PTM substrate sites obtained from existing databases and manual curation of literature, of which more than 2 235 000 entries are experimentally verified. This update has manually curated over 42 new modification types that were not included in the previous version. Due to the increasing number of studies on the mechanism of PTMs in the past few years, a great deal of upstream regulatory proteins of PTM substrate sites have been revealed. The updated dbPTM thus collates regulatory information from databases and literature, and merges them into a protein-protein interaction network. To enhance the understanding of the association between PTMs and molecular functions/cellular processes, the functional annotations of PTMs are curated and integrated into the database. In addition, the existing PTM-related resources, including annotation databases and prediction tools are also renewed. Overall, in this update, we would like to provide users with the most abundant data and comprehensive annotations on PTMs of proteins. The updated dbPTM is now freely accessible at https://awi.cuhk.edu.cn/dbPTM/.
A Tale of Two Regions: An Analysis of Two Decades of Belgian Public Opinion
Authors: Hooghe Marc , Stiers Dieter 
Published: October 2021

Abstract
It has been assumed that a trend toward devolution within a federal country would be associated with a growing apart of public opinion, and the federal kingdom of Belgium is routinely cited as an obvious example in this regard. Since the publication of the seminal Billiet et al. article, more competences have been devolved toward the autonomous regions, and in this research note we update the expectation that this has led to a further growing apart of public opinion in the country. Based on both electoral studies (2009/2014/2019), and the European Social Survey (2002–2018) we investigate whether these institutional differences are associated with a growing apart of public opinion in the regions of Belgium. Our results suggest that while there are clear attitudinal differences between the two major groups in the country, these differences are stable throughout the three-decade observation period. Differences are becoming more outspoken, however, with regard to the preferred extent of federalism. Interestingly, however, the dynamics in public opinion in this regard do not follow the same pattern as electoral results would suggest.
Postoperative Evaluation and Management of Portomesenteric Venous Thrombosis in Patients With IBD
Authors: Patel Maitri , Hedrick Traci 
Published: October 2021

CASE SUMMARY:
A 22-year-old woman with medically refractory ulcerative pancolitis underwent laparoscopic total proctocolectomy with IPAA and diverting ileostomy. She was discharged on postoperative day 4 feeling well. Because of the lack of risk factors for venous thromboembolism (including no family history or use of oral contraceptives), she was not discharged with prophylactic low-molecular-weight heparin, but she received low-molecular-weight heparin while in the hospital. The following day, she developed abdominal pain, nausea/vomiting, and decreased ostomy output. An abdominopelvic CT scan demonstrated a small amount of intraperitoneal free air felt to be postoperative in nature, small-bowel dilation consistent with ileus, and extensive portal and superior mesenteric vein thrombosis. She was started on low-molecular-weight heparin that resulted in rapid improvement. A subsequent repeat CT scan a few days later showed decreased clot burden.
Utility of bedside ultrasound derived hepatic and renal parenchymal flow patterns to guide management of acute kidney injury
Authors: Jury David , Shaw Andrew D. 
Published: October 2021

Purpose of review
Ideal fluid management of critically ill patients is maintaining an adequate perfusion pressure but avoiding venous congestion. Venous excess ultrasound score (VExUS) quantifies venous congestion to guide the management of fluid balance.

Recent findings
VExUS of abdominal veins measures fluid tolerance and helps clinicians avoid congestion. VExUS scoring predicts the development of acute kidney injury (AKI) that is a common hospital problem resulting in higher mortality and morbidity. VExUS can predict patients at risk of developing AKI post cardiac surgery. VExUS has been associated with an increase in adverse outcomes in a general intensive care population. Hepatic vein ultrasound can manifest as a sequela of right heart failure and pulmonary hypertension. Intrarenal congestion suggests poorer prognosis in heart failure patients. VExUS score has been used in decision-making to remove fluid in patients with cardiorenal syndrome. VExUS scoring may help curtail overly aggressive fluid resuscitation for patients with septic shock and help avoid iatrogenic ‘salt water drowning’

Summary
We summarize the technique and clinical practice of VExUS to help guide fluid balance across different populations of critically ill patients.
Faecal microbiota replacement to eradicate antimicrobial resistant bacteria in the intestinal tract – a systematic review
Authors: Bilsen Manu P. , Lambregts Merel M.C. , van Prehn Joffrey , Kuijper Ed J. 
Published: October 2021

Purpose of reviewAntimicrobial resistance is a rising threat to global health and is associated with increased mortality. Intestinal colonisation with multidrug-resistant organisms (MDRO) can precede invasive infection and facilitates spread within communities and hospitals. Novel decolonisation strategies, such as faecal microbiota transplantation (FMT), are being explored. The purpose of this review is to provide an update on how the field of FMT for MDRO decolonisation has developed during the past year and to assess the efficacy of FMT for intestinal MDRO decolonisation.Recent findingsSince 2020, seven highly heterogenous, small, nonrandomised cohort studies and five case reports have been published. In line with previous literature, decolonisation rates ranged from 20 to 90% between studies and were slightly higher for carbapenem-resistantEnterobacteriaceaethan vancomycin-resistantEnterococcus. Despite moderate decolonisation rates in two studies, a reduction in MDRO bloodstream and urinary tract infections was observed.Summary and implicationsAlthough a number of smaller cohort studies show some effect of FMT for MDRO decolonisation, questions remain regarding the true efficacy of FMT (taking spontaneous decolonisation into account), the optimal route of administration, the role of antibiotics pre and post-FMT and the efficacy in different patient populations. The observed decrease in MDRO infections post-FMT warrants further research.
Surgical Versus Nonsurgical Lower Face Contouring: Layperson Perceptions of Attractiveness and Personality Traits
Authors: Chen Jonlin , Abousy Mya , Chow Amanda , Girard Alisa , Jenny Hillary , Choi Jong-Woo , Yang Robin 
Published: October 2021

Background:
Traditional approaches to lower face contouring involve ostectomy of the mandibular angle or body. More recently, nonsurgical techniques have gained popularity, including neurotoxin injection to the masseter muscle. This study aims to evaluate layperson perceptions of patient attractiveness and personality traits following lower face contouring using either surgical or nonsurgical treatment.

Methods:
In this survey study distributed via Amazon's Mechanical Turk, respondents viewed a series of 14 patient images obtained in clinic before and after surgical or nonsurgical jawline slimming, or without any facial aesthetic procedure. Respondents rated changes in attractiveness and personality trait scores between the before and after image (score: −50 to 50, with 50 representing the greatest posttreatment increase and 0 representing no change). We used descriptive statistics and multivariable regression to determine differences in respondent ratings between patient images.

Results:
A total of 415 respondents (mean age 38 years, 50.6% female) successfully completed the survey. Compared to patients who underwent nonsurgical treatment, those who received surgery had significantly greater increases in perceived attractiveness (P < 0.001), femininity (P < 0.001), friendliness (P < 0.001), intelligence (P < 0.001), trustworthiness (P < 0.001), financial wealthiness (P < 0.001), dominance (P < 0.01), and self-esteem (P < 0.001). Gonial angles increased and jaw widths decreased following both surgical and nonsurgical intervention, with no statistically significant difference between treatment groups.

Conclusions:
From the layperson perspective, surgical compared to nonsurgical jawline contouring offers greater improvements in perceptions of attractiveness and favorable personality traits.
Re-assessing the phylogenetic status and evolutionary relationship of Forest Owlet [Athene blewitti(Hume 1873)] using genomic data
Authors: Vinay K.L , Natesh Meghana , Mehta Prachi , Jayapal Rajah , Mukherjee Shomita , Robin V.V. 
Published: October 2021

ABSTRACTPhylogenetic relationships are often challenging to resolve in recent/younger lineage when only a few loci are used. Ultra Conserved Elements (UCE) are highly conserved regions across taxa that help resolve shallow and deep divergences. We utilized UCEs harvested from whole genomes to assess the phylogenetic position and taxonomic affiliation of an endangered endemic owlet in the family Strigidae – the Forest OwletAthene blewitti. The taxonomic placement of this species has been revised multiple times. A multigene study attempted to address the question but showed a discrepancy across datasets in its placement of the species within genusAthene. We assembled a dataset of 5018 nuclear UCE loci with increased taxon sampling. Forest Owlet was found to be an early split from theAtheneclade but sister to otherAthene;and consistent across three approaches - maximum likelihood, bayesian, and the multispecies coalescence. Divergence dating using fossil calibrations suggest that theAthenelineage split from its ancestor about 7.6Mya, and the Forest Owlet diverged about 5.2Mya, consistent with previous multigene approaches. Despite osteological differences from otherAthene, we suggest the placement of the Forest Owlet as a member of theAtheneto emphasize its evolutionary relationship.Graphical AbstractHIGHLIGHTSPhylogenomics using genome-wide nuclear markers yielded a well-supported topology forAtheneandGlaucidiumlineages.Three different methods of phylogenetic tree construction showed that Forest Owlet is an early split from all otherAthenespecies.Divergence dating in the bayesian framework puts the Forest Owlet age between 5.0my to 5.5my.
phylogatR: Phylogeographic data aggregation and repurposing
Authors: Pelletier Tara A , Parsons Danielle J , Decker Sydney K , Crouch Stephanie , Franz Eric , Ohrstrom Jeffery , Carstens Bryan C 
Published: October 2021

AbstractPatterns of genetic diversity within species contain information about the history of that species, including how they have responded to historical climate change and how easily the organism is able to disperse across its habitat. More than 40,000 phylogeographic and population genetic investigations have been published to date, each collecting genetic data from hundreds of samples. Despite these millions of data points, meta-analyses are challenging because the synthesis of results across hundreds of studies, each using different methods and forms of analysis, is a daunting and time-consuming task. It is more efficient to proceed by repurposing existing data and using automated data analysis. To facilitate data repurposing, we created a database (phylogatR)that aggregates data from different sources and conducts automated multiple sequence alignments and data curation to provide users with nearly ready-to-analyze sets of data for thousands of species. Two types of scientific research will be made easier byphylogatR, large meta-analyses of thousands of species that can address classic questions in evolutionary biology and ecology and student- or citizen-science based investigations that will introduce a broad range of people to the analysis of genetic data.phylogatRenhances the value of existing data via the creation of software and web-based tools that enable these data to be recycled and reanalyzed and increase accessibility to big data for research labs and classroom instructors with limited computational expertise and resources.
gJLS2: An R package for generalized joint location and scale analysis in X-inclusive genome-wide association studies
Authors: Deng Wei Q. , Sun Lei 
Published: October 2021

AbstractA joint analysis of location and scale can be a powerful tool in genome-wide association studies to uncover previously overlooked markers that influence a quantitative trait through both mean and variance, as well as to prioritize candidates for gene-environment interactions. This approach has recently been generalized to handle related samples, dosage data, and the analytically challenging X-chromosome. We disseminate the latest advances in methodology through a user-friendly R software package with added functionalities to support genome-wide analysis on individual-level or summary-level data. The implemented R package can be called from PLINK or directly in a scripting environment, to enable a streamlined genome-wide analysis for biobank-scale data. Application results on individual-level and summary-level data highlight the advantage of the joint test to discover more genome-wide signals as compared to a location or scale test alone. We hope the availability of gJLS2 software package will encourage more scale and/or joint analyses in large-scale datasets, and promote the standardized reporting of their p-values to be shared with the scientific community.
Local adaptation and spatiotemporal patterns of genetic diversity revealed by repeated sampling of Caenorhabditis elegans across the Hawaiian Islands
Authors: Crombie Timothy A. , Battlay Paul , Tanny Robyn E. , Evans Kathryn S. , Buchanan Claire M. , Cook Daniel E. , Dilks Clayton M. , Stinson Loraina A. , Zdraljevic Stefan , Zhang Gaotian , Roberto Nicole M. , Lee Daehan , Ailion Michael , Hodgins Kathryn A. , Andersen Erik C. 
Published: October 2021

AbstractThe nematode Caenorhabditis elegans is among the most widely studied organisms, but relatively little is known about its natural ecology. Wild C. elegans have been isolated from both temperate and tropical climates, where they feed on bacteria associated with decomposing plant material. Genetic diversity is low across much of the globe but high in the Hawaiian Islands and across the Pacific Rim. The high genetic diversity found there suggests that: (1) the origin of the species lies in Hawaii or the surrounding Pacific Rim; and (2) the ancestral niche of the species is likely similar to the Hawaiian niche. A recent study of the Hawaiian niche found that genetically distinct groups appeared to correlate with elevation and temperature, but the study had a limited sample size. To better characterize the niche and genetic diversity of C. elegans on the Hawaiian Islands and to explore how genetic diversity might be influenced by local adaptation, we repeatedly sampled nematodes over a three-year period, measured various environmental parameters at each sampling site, and whole-genome sequenced the C. elegans isolates that we identified. We found that the typical Hawaiian C. elegans niche is moderately moist native forests at high elevations (500 to 1500 meters) where temperatures are cool (15 to 20°C). We measured levels of genetic diversity and differentiation among Hawaiian strains and found evidence of seven genetically distinct groups distributed across the islands. Then, we scanned these genomes for signatures of local adaptation and identified 18 distinct regions that overlap with hyperdivergent regions, which are likely maintained by balancing selection and enriched for genes related to environmental sensing, xenobiotic detoxification, and pathogen resistance. These results provide strong evidence of local adaptation among Hawaiian C. elegans and a possible genetic basis for this adaptation.