bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life and phonatory and morphological outcomes in cognitively unimpaired adolescents with Pierre Robin sequence: a cross-sectional study of 72 patients
Authors: Thouvenin Béatrice , Soupre Véronique , Caillaud Marie-Anne , Henry-Mestelan Charlotte , Chalouhi Christel , Houssamo Bachar , Chapuis Cécile , Lind Katia , Royer Aurélie , Vegas Nancy , Amiel Jeanne , Couly Gérard , Picard Arnaud , Vaivre-Douret Laurence , Abadie Véronique 
Published: October 2021

Abstract
Background
Pierre Robin sequence (PRS) is a heterogeneous condition involving retro(micro)gnathia, glossoptosis and upper airway obstruction, very often with posterior cleft palate. Patients with PRS, either isolated or associated with Stickler syndrome have good intellectual prognosis. Nevertheless, the quality of life in adolescence and the phonatory and morphological outcomes are rarely analysed. We assessed the phonatory and morphological outcomes of 72 cognitively unimpaired adolescents with PRS, studied their oral (COHIP-SF19), vocal (VHI-9i) and generic quality of life (QoL; KIDSCREEN-52), and searched for determinants of these outcomes.

Results
Two-thirds of our adolescents retained low or moderate phonation difficulties, but risk factors were not identified. For 14%, morphological results were considered disharmonious, with no link to neonatal retrognathia severity. Only one vs two-stage surgery seemed to affect final aesthetic results. The oral QoL of these adolescents was comparable to that of control patients and was significantly better than that of children with other craniofacial malformations (COHIP-SF19 = 17.5, 15.4 and 25.7, respectively). The oral QoL of the adolescents with non-isolated PRS was significantly worse (COHIP-SF19 = 24.2) than that of control patients and close to that of children with other craniofacial malformations. The vocal QoL of the adolescents (mean [SD] VHI-9i = 7.5 [5.4]) was better than that of patients with other voice pathologies and better when phonation was good. The generic QoL of the adolescents was satisfactory but slightly lower than that of controls, especially in dimensions concerning physical well-being, relationships and autonomy. QoL results were lower for adolescents with non-isolated than isolated PRS. Only non-isolated PRS and low oral QoL affected generic QoL.

Conclusion
Morphological or phonatory impairments remain non-rare in adolescents with PRS but do not seem to be directly responsible for altered QoL. These adolescents, especially those with non-isolated PRS, show self-confidence and social-relation fragility. We must focus on long-term functional and psychological results for PRS patients and improve therapy protocols and follow-up, notably those affecting the oral aspects of the disease.
Efficacy of expressive helping in adult hematologic cancer patients undergoing stem cell transplant: protocol for the Writing for Insight, Strength, and Ease (WISE) study’s two-arm randomized controlled trial
Authors: Whitmore Lauren , Schulte Taylor , Bovbjerg Katrin , Hartstein Madison , Austin Jane , Luta George , McFarland Lily , Rowley Scott D. , Nyirenda Themba , Lewis-Thames Marquita , Stanton Annette L. , Valdimarsdottir Heiddis , Graves Kristi , Rini Christine 
Published: October 2021

Abstract
Background
During, shortly after, and sometimes for years after hematopoietic stem cell transplant, a large proportion of hematological cancer patients undergoing transplant report significant physical and psychological symptoms and reduced health-related quality of life. To address these survivorship problems, we developed a low-burden, brief psychological intervention called expressive helping that includes two theory- and evidence-based components designed to work together synergistically: emotionally expressive writing and peer support writing. Building on evidence from a prior randomized control trial showing reductions in physical symptoms and distress in long-term transplant survivors with persistent survivorship problems, the Writing for Insight, Strength, and Ease (WISE) trial will evaluate the efficacy of expressive helping when used during transplant and in the early post-transplant period, when symptoms peak, and when intervention could prevent development of persistent symptoms.

Methods
WISE is a multi-site, two-arm randomized controlled efficacy trial. Adult hematological cancer patients scheduled for a hematopoietic stem cell transplant will complete baseline measures and then, after hospitalization but prior to transplant, they will be randomized to complete either expressive helping or a time and attention “neutral writing” task. Both expressive helping and neutral writing involve four brief writing sessions, beginning immediately after randomization and ending approximately 4 weeks after hospital discharge. Measures of symptom burden (primary outcome), distress, health-related quality of life, and fatigue (secondary outcomes) will be administered in seven assessments coinciding with medically relevant time points from baseline and to a year post-intervention.

Discussion
The steady and continuing increase in use of stem cell transplantation has created growing need for efficacious, accessible interventions to reduce the short- and long-term negative physical and psychosocial effects of this challenging but potentially life-saving treatment. Expressive helping is a psychological intervention that was designed to fill this gap. It has been shown to be efficacious in long-term transplant survivors but could have even greater impact if it is capable of reducing symptoms during and soon after transplant. The WISE study will evaluate these benefits in a rigorous randomized controlled trial.

Trial registration
Clinicaltrial.govNCT03800758. Registered January 11, 2019
Multifunctional alkalophilic α-amylase with diverse raw seaweed degrading activities
Authors: Gu Xiaoqian , Fu Liping , Pan Aihong , Gui Yuanyuan , Zhang Qian , Li Jiang 
Published: October 2021

AbstractUncultured microbes are an important resource for the discovery of novel enzymes. In this study, an amylase gene (amy2587) that codes a protein with 587 amino acids (Amy2587) was obtained from the metagenomic library of macroalgae-associated bacteria. Recombinant Amy2587 was expressed in Escherichia coli BL21 (DE3) and was found to simultaneously possess α-amylase, agarase, carrageenase, cellulase, and alginate lyase activities. Moreover, recombinant Amy2587 showed high thermostability and alkali resistance which are important characteristics for industrial application. To investigate the multifunctional mechanism of Amy2587, three motifs (functional domains) in the Amy2587 sequence were deleted to generate three truncated Amy2587 variants. The results showed that, even though these functional domains affected the multiple substrates degrading activity of Amy2587, they did not wholly explain its multifunctional characteristics. To apply the multifunctional activity of Amy2587, three seaweed substrates (Grateloupia filicina, Chondrus ocellatus, and Scagassum) were digested using Amy2587. After 2 h, 6 h, and 24 h of digestion, 121.2 ± 4 µg/ml, 134.8 ± 6 µg/ml, and 70.3 ± 3.5 µg/ml of reducing sugars were released, respectively. These results show that Amy2587 directly and effectively degraded three kinds of raw seaweeds. This finding provides a theoretical basis for one-step enzymatic digestion of raw seaweeds to obtain seaweed oligosaccharides.
Characterisation of the chemo-mechanical behaviour of clays polluted by BTEX: a case study of benzene
Authors: KAHLOUCHE Hicham , GHERIS Abderrahim , GUENFOUD Mohamed 
Published: October 2021

AbstractIn chemo-mechanical coupling of clays, chemical phenomena are likely to have a stronger influence on the mechanical behaviour and mechanical actions can modify the chemical behaviour. The understanding of these different phenomena, taking into account the coupled mechanisms, is essential in the context of the problem of the durability of structures and works built on polluted sites. Thus, the laboratory characterisation of the chemo-mechanical behaviour of a clay contaminated by light hydrocarbon pollutant (BTEX: benzene) was carried out. First in the absence of pollutants, i.e., by the presence of water only, then under the influence of the pollutant, all in two stages: with no external stress, then under imposed external stress. This study presents an experimental protocol based on a series of uniaxial consolidation tests, specific oedometric tests and direct shear strength, this tests performed under controlled saturation conditions and in the presence of organic contamination by benzene. All results confirm the influence of pollutants in different concentrations on the mechanical behaviour of the soil. They show a strong increase in compressibility and a significant increase in swelling, the soil becomes more cohesive, low friction and less elastic. Furthermore, the results show that external load forces play a major role in modifying the behaviour of clay.
Primary gastric synovial sarcoma resected by laparoscopic endoscopic cooperative surgery of the stomach: a case report
Authors: Shibata Ryosuke , Morishita Marina , Koreeda Nobuhiko , Hirano Yousuke , Kaida Hiroki , Ohmiya Toshihiro , Uwatoko Shugo , Kawamoto Makoto , Komono Akira , Sakamoto Ryohei , Miyasaka Yoshihiro , Higashi Daijiro , Tanabe Hiroshi , Nimura Satoshi , Watanabe Masato 
Published: October 2021

Abstract
Background
Primary gastric synovial sarcoma is extremely rare, only 44 cases have been reported so far, and there have been no reports of laparoscopic endoscopic cooperative surgery for this condition.

Case presentation
A 45-year-old male patient presented with gastric pain. Esophagogastroduodenoscopy was performed that led to the identification of an 8-mm submucosal tumor in the anterior wall of the antrum, and a kit-negative gastrointestinal stromal tumor was suspected following biopsy. On endoscopic ultrasonography, the boundary of the tumor, mainly composed of the second layer, was depicted as a slightly unclear low-echo region, and a pointless no echo region was scattered inside. A boring biopsy revealed synovial sarcoma. Positron emission tomography did not reveal fluorodeoxyglucose (18F-FDG) accumulation in the stomach or other organs. Thus, the patient was diagnosed with a primary gastric synovial sarcoma, and laparoscopic endoscopic cooperative surgery was performed. The tumor of the antrum could not be confirmed laparoscopically from the serosa, and under intraoperative endoscopy, it had delle on the mucosal surface, which was removed by a method that does not involve releasing the gastric wall. Immunohistochemistry showed that the spindle cells were positive for EMA, BCL-2 protein, TLE-1, and SS18-SSX fusion-specific antibodies but negative for KIT and DOG-1. The final pathological diagnosis was synovial sarcoma of the stomach. The postoperative course was good, and the patient was discharged from the hospital on the 11th postoperative day.

Conclusion
Resection with laparoscopic endoscopic cooperative surgery (LECS), which has not been reported before, was effective for small synovial sarcomas that could not be confirmed laparoscopically. With the combination of laparoscopic and endoscopic approaches to neoplasia with a non-exposure technique (CLEAN-NET) procedure, it was possible to excise the tumor with the minimum excision range of the gastric serosa without opening the stomach.
Migration outside large cities: a comparison of the hiring of migrants for the food processing industry in the United States and Japan
Authors: Mazumi Yusuke 
Published: October 2021

AbstractRecent studies suggest that the hiring of migrants in the food processing industry has increased the migrant population outside large cities among affluent migrant-receiving countries. This study examines how the U.S. meatpacking industry and the Japanese seafood processing industry, in particular, have developed a dependence on migrants; it does so to identify whether and how a common—thus cross-nationally generalizable—process may account for migration outside large cities. A comparative historical analysis revealed that, with significant national differences between the United States and Japan, including in the legal and institutional contexts of migration, there is little commonality in the processes through which the industries have come to depend on migrants. Yet, there is a similarity in the development of mass production. Such production necessitates an undisrupted availability of full-time as well as low-wage workforce, and migrants on both sides of the Pacific are employed to ensure this availability. Thus, while urban-centered migration studies often emphasize the growth of low-wage services or small-batch manufacturing as an economic driver of migration, this study argues that, outside large cities, a different pattern of industrial transformation is associated with labor migration.
The relationship of mean temperature and 9 collected butterfly species’ wingspan as the response of global warming
Authors: Na Sumi , Lee Eunyoung , Kim Hyunjung , Choi Seiwoong , Yi Hoonbok 
Published: October 2021

Abstract
Background
Organism body size is a basic characteristic in ecology; it is related to temperature according to temperature-size rule. Butterflies are affected in various aspects by climate change because they are sensitive to temperature. Therefore, this study was conducted to understand the effect of an increase in temperature due to global warming on the wing of butterflies.

Results
A total of 671 butterflies belonging to 9 species were collected from 1990 to 2016 in Seoul (336 specimens) and Mokpo (335 specimens). Consequently, as the mean temperature increased, the wing length of the species increased. However, there are exceptions that the Parnassius stubbendorfii, Pieridae canidia, and Pieris rapae wing length of Seoul increased, but the butterfly wing length of Mokpo decreased.

Conclusions
The positive correlations between the butterfly wing length and mean temperature showed that the change of mean temperature for about 26 years affects the wing length of butterfly species. The exception is deemed to have been influenced by the limited research environment, and further studies are needed. We would expect that it can be provided as basic data for studying effect of climate change.
PET/CT uncovers cranial giant cell arteritis
Authors: Anati Tamer , Hoffman Ben Shabat Michal 
Published: October 2021

Abstract
Background
Giant cell arteritis (GCA) is an inflammation of large and medium sized vessels, mainly affecting people over 50 years of age. Diagnosis needs to be made quickly to prevent complications. Steroids treatment should be started once diagnosis is made.

Case presentation
Here we reported a case of cranial GCA in a 82-year-old man. [18F]FDG PET/CT imaging demonstrated higher FDG uptake in medium sized and cranial vessels. Glucocorticoid treatment was started, followed by a rapid and marked improvement of symptoms and inflammatory markers.

Conclusions
This case report supports the role of PET/CT hybrid imaging as a useful noninvasive tool in the evaluation of cranial GCA.
Hypertension care cascade at a large urban HIV clinic in Uganda: a mixed methods study using the Capability, Opportunity, Motivation for Behavior change (COM-B) model
Authors: Muddu Martin , Ssinabulya Isaac , Kigozi Simon P. , Ssennyonjo Rebecca , Ayebare Florence , Katwesigye Rodgers , Mbuliro Mary , Kimera Isaac , Longenecker Chris T. , Kamya Moses R. , Schwartz Jeremy I. , Katahoire Anne R. , Semitala Fred C. 
Published: October 2021

Abstract
Background
Persons living with HIV (PLHIV) receiving antiretroviral therapy (ART) have a high prevalence of hypertension (HTN) and increased risk of mortality from cardiovascular diseases. HTN and HIV care integration is recommended in Uganda, though its implementation has lagged. In this study, we sought to analyze the HTN and HIV care cascades and explore barriers and facilitators of HTN/HIV integration within a large HIV clinic in urban Uganda.

Methods
We conducted an explanatory sequential mixed methods study at Mulago ISS clinic in Kampala, Uganda. We determined proportions of patients in HTN and HIV care cascade steps of screened, diagnosed, initiated on treatment, retained, and controlled. Guided by the Capability, Opportunity, Motivation and Behavior (COM-B) model, we then conducted semi-structured interviews and focus group discussions with healthcare providers (n = 13) and hypertensive PLHIV (n = 32). We coded the qualitative data deductively and analyzed the data thematically categorizing them as themes that influenced HTN care positively or negatively. These denoted barriers and facilitators, respectively.

Results
Of 15,953 adult PLHIV, 99.1% were initiated on ART, 89.5% were retained in care, and 98.0% achieved control (viral suppression) at 1 year. All 15,953 (100%) participants were screened for HTN, of whom 24.3% had HTN. HTN treatment initiation, 1-year retention, and control were low at 1.0%, 15.4%, and 5.0%, respectively. Barriers and facilitators of HTN/HIV integration appeared in all three COM-B domains. Barriers included low patient knowledge of HTN complications, less priority by patients for HTN treatment compared to ART, sub-optimal provider knowledge of HTN treatment, lack of HTN treatment protocols, inadequate supply of anti-hypertensive medicines, and lack of HTN care performance targets. Facilitators included patients’ and providers’ interest in HTN/HIV integration, patients’ interest in PLHIV peer support, providers’ knowledge and skills for HTN screening, optimal ART adherence counseling, and availability of automated BP machines.

Conclusion
The prevalence of HTN among PLHIV is high, but the HTN care cascade is sub-optimal in this successful HIV clinic. To close these gaps, models of integrated HTN/HIV care are urgently needed. These findings provide a basis for designing contextually appropriate interventions for HTN/HIV integration in Uganda and other low- and middle-income countries.
Association between carpal tunnel syndrome and trigger finger: a clinical and electrophysiological study
Authors: Saba Emmanuel Kamal Aziz 
Published: October 2021

Abstract
Background
Carpal tunnel syndrome is a prevalent mononeuropathy. Trigger finger is a flexor stenosing tenosynovitis. The aim of the study was to assess the concomitant occurrence of carpal tunnel syndrome and trigger finger in the same hand among patients presented with idiopathic carpal tunnel syndrome or idiopathic trigger finger. The study included 110 hands (75 patients) presented with carpal tunnel syndrome or trigger finger and 60 asymptomatic hands (46 apparently healthy individuals). Clinical assessment and neurophysiological evaluation were done.

Results
Regarding the presenting clinical complaints, there were 76 hands (69.1%) from 48 patients (64.0%) presented with idiopathic carpal tunnel syndrome. There 34 hands (30.9%) from 27 patients (36.0%) presented with idiopathic trigger finger. Classification of the patients into three groups depending on the final diagnosis: (I) carpal tunnel syndrome group, 57 hands (51.8%) with only carpal tunnel syndrome from 36 patients (48.0%); (II) trigger finger group, 25 hands (22.7%) with only trigger finger from 22 patients (29.3%); and (III) carpal tunnel syndrome with trigger finger group, 28 hands (25.5%) with both conditions from 24 patients (32.0%); and among them, seven patients had contralateral hand carpal tunnel syndrome only. The duration of complaints among the carpal tunnel syndrome with trigger finger group was significantly shorter than that in the other two groups. There were statistically significantly higher values of patient global assessment of hand symptoms and effect of hand symptoms on function and quality of life among the carpal tunnel syndrome with trigger finger group versus the other two groups. There was no statistically significant difference between the carpal tunnel syndrome with trigger finger group versus the carpal tunnel syndrome group regarding different classes of the Padua neurophysiological classification scale. The most common digit to have trigger finger was the middle finger in 19 hands (35.8%).

Conclusions
The concurrent presentation of idiopathic carpal tunnel syndrome and idiopathic trigger finger in the same hand is common. Each of them could be associated with the other one. The symptoms of one of them usually predominate the patient’s complaints. The identification of this association is essential for proper diagnosis and comprehensive management of patients presented with these conditions.
Reading Seoul in Pyongyang: Cross-Border Mediascapes in Early Cold War North Korea
Authors: Kief I Jonathan 
Published: October 2021

Abstract
This article argues that the North Korean mediascape of the 1950s and 1960s must be understood in relationship to its interaction with publications from the South. To do so, it makes three methodological interventions. First, it demonstrates how North Korean writers’ own practices of citation can be used to outline the extensive and expanding body of South Korean texts available in the North during this period. Second, it shows how a focus on such references and their changing character allows us to see a shift in the late 1950s and early 1960s: one that enabled a selection of South Korean texts to be reprinted in the North, producing intersecting reading publics. Finally, it demonstrates how an understanding of this changing relationship to South Korean texts illuminates changing writing practices in the North and the hybrid texts linking North and South Korean authorship that they produced. The article thus contends that the 1950s and 1960s mediascapes of the two Koreas must be seen as imbricated rather than isolated entities.
Effects of Blood Flow Restriction Training on Blood Perfusion and Work Ability of Muscles in Elite Para-alpine Skiers
Authors: GENG YU , ZHANG LEI , WU XUEPING 
Published: October 2021

ABSTRACT

Purpose
The effects of short-term blood flow restriction (BFR) exercise on muscle blood flow perfusion and performance during high-intensity exercise were determined in elite para-alpine standing skiers to assess whether this would be an effective training regimen for elite athletes with disabilities.

Methods
Nine national-level para-alpine standing skiers (mean age, 20.67 ± 1.34 yr; four women) were recruited. Nondominant lower limbs were trained with BFR (eight in final analyses), and dominant lower limbs were trained without BFR (seven in final analyses). The 2-wk protocol included high-load resistance, local muscle endurance (circuit resistance training), and aerobic endurance (stationary cycling) training performed 4 times a week, with BFR during local muscle endurance and aerobic endurance sessions. Muscle strength was measured by maximal voluntary isometric contraction (MVIC) in the knee extensors; microcirculatory blood perfusion (MBP), by laser Doppler blood flow; and muscle strength and endurance, by the total amount of work (TW) performed during high-intensity centrifugal and concentric contractions.

Results
BFR significantly increased absolute and relative MVIC (P < 0.001, P = 0.001), MBP (P = 0.011, P = 0.008), and TW (P = 0.006, P = 0.007) from pretraining values, whereas only absolute MVIC increased without BFR (P = 0.047). However, the MVIC increase with BFR exercise (35.88 ± 14.83 N·m) was significantly greater (P = 0.040) than without BFR exercise (16.71 ± 17.79 N·m).

Conclusions
Short-term BFR exercise significantly increased strength endurance, muscle strength, and MBP in national-level para-alpine standing skiers. Our study provides new evidence that BFR exercise can improve local muscle blood perfusion during high-intensity exercise and informs BFR exercise strategies for athletes with disabilities.