bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytoestrogens as Potential Antiandrogenic Agents Against Prostate Cancer:
An In Silico Analysis
Authors: Agrawal Neetu , Mujwar Somdutt , Goyal Ahsas , Gupta Jeetendra Kumar 
Published: August 2021

Background:
Prostate cancer is the second most common cancer worldwide. The androgen
deprivation therapy or castration leads to the recurrence of castration-resistant prostate cancer
after some time. Androgen receptor is one of the most promising targets for the treatment of prostate
cancer. The health benefits of phytoestrogens led us to explore them for their androgen receptor inhibition
potential that may lead to inhibition of initiation and progression of prostate cancer.

Methods:
Protein-ligand interaction plays a central role in structure-based drug design, so we
screened 23 phytoestrogens for their binding affinity to the androgen receptor using the molecular
docking approach. These phytoestrogens were also tested for their ADME and toxicity profiles using
the software.

Results:
Based on binding affinity, interacting amino acid residues, pharmacokinetics and toxicity
profile, four phytoestrogens, namely naringenin, luteolin, hesperetin, and biochanin A were shortlisted
as lead molecules.

Conclusion:
Therefore, our study has shown that these four phytoestrogens could be promising candidates
for further evaluation for prostate cancer treatment or management.
A Novel LC-MS Method for the Determination of Abiraterone in Rat Plasma
and its Application to Pharmacokinetic Studies
Authors: Dai Linzhi , Lv Pei , He Yun , Wang Xiaoli , Chen Lili , Dai Jing 
Published: August 2021

Background:
High-Performance Liquid Chromatography (HPLC)-Ultraviolet (UV) and
Liquid Chromatography (LC)-Mass Spectrometry (MS)/MS methods have been used to analyse abiraterone
(ART); however, a single-quadrupole mass spectrometer with LC-MS systems has never
been used to analyse ART.

Objective:
The study aimed to establish a novel, simple assay of quantitating ART in rat plasma
through LC-MS.

Method:
The analytical procedure involved the extraction of ART and D4-ART (internal standard,
IS) from rat plasma through simple protein precipitation. Chromatographic separation was
achieved using an isocratic mobile phase (acetonitrile: 5 mM ammonium formate with 0.1% formic
acid, 50:50 v/v) at a flow rate of 0.30 mL/min on a Waters XBridge® C18 column with a total run
time of 5 min. LC-MS ion transitions monitored were 350.1 and 354.1 for ART and IS, respectively.
The method was validated, and the results met acceptance criteria.

Results:
The lower limit of quantitation achieved was 1 ng/mL, and linearity was 1-8000 ng/mL.
The intra- and inter-day precisions were 1.26%-14.20% and 5.49%-13.08%, respectively, in rat
plasma.

Conclusion:
LC-MS offers a novel, specific, sensitive, and accurate method for quantifying ART
and it was successfully applied to pharmacokinetic studies of ART in rats.
Nueva evidencia de un esqueleto humano del Holoceno temprano procedente de Tláhuac
Authors: Serrano Sánchez Carlos , Hernández Flores Rocío , Gómez-Valdés Jorge Alfredo 
Published: August 2021

<p>El objetivo de este trabajo es dar a conocer un hallazgo de restos humanos del llamado periodo precerámico, ocurrido de forma accidental al sur de la cuenca de México, en el poblado de Tláhuac de la Ciudad de México. Son los restos de un esqueleto casi completo, aunque en estado multifragmentado, a excepción del cráneo. El análisis osteológico indica que se trata de un individuo adulto joven de sexo femenino, al que hemos denominado la Mujer de Tláhuac. Su edad radiocarbónica se estimó en 8330 + 40 años BP (95.4%, 9465 - 9260 cal BP); fechamiento que corresponde al de algunos restos considerados “paleoamericanos”. Exploramos la variación del patrón morfológico craneofacial de la mujer Tláhuac aplicando análisis de componentes principales (PCA) comparativamente con otros especímenes de México, Brasil y Estados Unidos que datan del Pleistoceno tardío al Holoceno medio. Sin embargo, a pesar de su cronología, este ejemplar difiere del grado morfológico predominante a fines del Pleistoceno y se asemeja más a la población nativa americana moderna. </p><div> </div>
Politraumatizados atendidos en el servicio de cirugía general de un hospital de tercer nivel de Honduras: Caracterización clínico-epidemiológica
Authors: Alas César Ulises 
Published: August 2021

Antecedentes: El politraumatismo se conoce como la asociación de múltiples lesiones traumáticas producidas por un mismo accidente y que suponen, aunque solo sea una de ellas, riesgo vital para el paciente. Esta es una de las causas de muerte más importantes a nivel mundial y comparado con otras patologías tiene una alta tasa de mortalidad. En Honduras es una de las mayores causas hospitalización y costos hospitalarios. Objetivo: Crear una caracterización clínica de los pacientes politraumatizados que se atienden en el servicio de emergencia de cirugía del Hospital Mario Catarino Rivas en el año 2017. Metodología: Estudio descriptivo observacional transversal y retrospectivo. Se analizó una muestra probabilística [IC 95%] que abarca 205 expedientes de pacientes politraumatizados atendidos en emergencia de cirugía obtenida por un muestreo estratificado mensual. Resultados: La media de edad del grupo es de 38,1 ± 6,3 años, la mediana de edad es de 33 años. El 79% (n= 162) de los ingresados corresponden al sexo masculino y 21% (n= 43) al sexo femenino. Los viernes y domingos son los días donde hubo mayor afluencia de paciente politraumatizado, 23,9 y 21,5% respectivamente. La afluencia de pacientes fue mayor entre las 6:00-12:00 de la mañana representando un 45,4%. El principal diagnóstico es la fractura de hueso largo 47,7%, seguido del traumatismo craneocefálico con 45,3%, traumatismo torácico y el traumatismo abdominal cada uno el 17,5%. La media de estancia intrahospitalaria fue de 16,3 ± 11 días. Conclusiones: Al tener conocimiento de los principales mecanismos de lesión del paciente politraumatizado del servicio se pueden tomar medidas para equipar la sala y al personal de salud para mejorar la atención del paciente politraumatizado.
Palabras claves: Politraumatismo, Accidente, Trauma.
Enfermedad de Cori-Forbes. A propósito de dos casos.
Authors: Romero María Fernanda , Mongelli Hernandez Scarlet Saret , Hoyos Vetencourt Yugledys Ruthliany , Santiago Peña Rafael José 
Published: August 2021

La glucogenosis tipo III (GSDIII) o enfermedad de Cori-Forbes es un trastorno causado por mutaciones en el gen AGL, que genera deficiencia de la enzima amilo-1,6-glucosidasa y el almacenamiento de dextrina límite en los tejidos afectados: hígado, músculo esquelético y cardíaco en GSDIIIa y sólo hígado en GSDIIIb. Se reportan dos casos: pacientes femenino y masculino, hermanos, de 7 y 5 años de edad respectivamente. Presentan aumento en el perímetro abdominal, extremidades delgadas, retardo del crecimiento pondoestatural, facies con mejillas redondas. Se observan alteraciones en valores sanguíneos como glicemia, colesterol HDL y VLDL, triglicéridos, AST, ALT, deshidrogenasa láctica y creatinasa. Se indicó plan dietético con suministro de maltodextrina a intervalos cortos de tiempo con restricción de sacarosa. El cumplimiento de la dieta y la valoración nutricional especializada lograron mejoría en la calidad de vida de los pacientes.
Palabras clave: Trastorno Metabólico, Enfermedad Metabólica, Glucogenosis Tipo III, Enfermedad De Cori-Forbes.
Evaluation of the Effect of Using 2,3-dichlorovinyl Dimethyl Phosphate (sniper) as Storage Insecticide on Quality of Cowpea (Vigna unguiculata (L.) Walp) Nutritional Content
Authors: Tizhe T. D. , Dagze J. K. , Yusuf C. S. , Jacob J. , Mallum S. M. 
Published: August 2021

The effect of 2, 3-dichlorovinyl dimethyl phosphate (sniper) application on the nutritional contents of cowpea over a period of time has been investigated. The chemical free cowpea samples were purchased directly from local farmers in Mubi town, Adamawa State. Three different treatment rates of 5, 10 and 15 ml of sniper were used. Each of the treatment rates was applied to 13 kg of cowpea and was placed in an air tight galloon. Another galloon containing 13 kg of cowpea without chemical treatment was used as the control sample. These were kept for a period of 30 and 60 days before analysis. The proximate and mineral components of the cowpea were analyzed using standard procedures. Assessment of the proximate composition revealed varied concentrations of protein, carbohydrate, ash, fat, crude fibre and moisture that ranges between 22.79-26.16%, 58.85-60.86%, 3.85-5.88%, 2.25-2.53%, 1.52-1.76% and 5.90-6.85%, respectively. Most of the proximate compositions were observed to decrease with increase in sniper concentration and storage duration. The proximate contents at 60 days after treatment application were observed to be significantly lower than that at 30 days. The mineral components analyzed ranges between 185.03-195.54 mg/100 g (P), 226.32-245.76 mg/100 g (Ca), 80.76-85.92 mg/100 g (Mg) and 595.25-642.34 mg/100 g (K) respectively; and at day 60 it ranges between 186.54-198.65 mg/100g, 251.07-262.73 mg/100 g, 86.48-90.12 mg/100 g and 650.06-700.04 mg/100 g respectively. The mineral contents were observed to increase with increase in treatment concentrations as well as storage duration. Therefore, sniper has significant effect on the proximate and mineral contents of cowpea. The effect depends on the rate and duration of storage. The use of sniper as an insecticide in the storage of cowpea should therefore be discouraged.
Performance Evaluation of a Hybrid Solar Collector in Two Different Climates
Authors: Alshibil Ahssan M. A. , Víg Piroska , Farkas István 
Published: August 2021

The solar hybrid collector (PV/T) modules are a beneficial approach that simultaneously transforms solar radiation into heat and electric power. This work examined the performance of a PV/T module with flat-plate absorber type and water-cooled by optimizing the PV/T model under two significantly different climate conditions. The first is for Stuttgart city, and the second is for Kabul. According to what has been conducted in this study, Kabul has a higher percentage of the received heat energy than Stuttgart, at more than 50.4%. Furthermore, Kabul's electrical efficiency is 48.3% higher than Stuttgart's. As a matter of fact, the annual radiation of Kabul is more than Stuttgart city by 49.12%. Thus, Kabul city seems to be more convenient than Stuttgart for the PV/T applications.
Efficacy of Oral Ketamine Combined with Psychotherapy for Treatment Resistant Depression
Authors: Zydb Tatiana , Hart MIchael 
Published: August 2021

Background: Treatment resistant depression (TRD) is defined as a major depressive episode that does not improve in response to at least two trials, each of a different class, of antidepressant medication. Pharmacotherapy of TRD with low dose ketamines has been shown as relatively successful in recent studies. Effects of such pharmacotherapy can be augmented by combining ketamine with psychotherapeutic interventions such as Zdyb’s Therapeutic Reset of Internal Processes (TRIP) protocol.
Method: 10 adult TRD patients (4 men, 6 women) were treated with low dose ketamines and were also receiving psychotherapeutic intervention as per TRIP protocol. All patients were administered the Patient Health Questionnaire, module 9 (PHQ9) which is a measure of a major depressive episode. The PHQ9 was administered twice: on baseline (i.e., prior to treatment) and after the treatment.
Results: On average, our patients fell in the moderate range of severity with respect to symptoms of TRD at baseline (pre-TRIP) as by their mean PHQ9 score of 17.9, (SD = 5.1). Their mean PHQ9 score decreased post TRIP treatment to 9.5 (SD = 6.6): the difference is significant in a t-test, t(10) = 4.3172, p = 0002 (two-tailed). The magnitude of the decrease amounts to 46.9% of the average baseline score.
Discussion and Conclusions: Our patients experienced significant reductions in symptoms of TRD in this pilot study. Research studies are now needed with control groups of TRD patients on a waiting list or also of those receiving only the ketamine pharmacotherapy.
Konsumen Muslim: Pengetahuan Produk Halal dalam Keputusan Pembelian Makanan
Authors: Musthofa Ariezal , Buhanudin Burhanudin 
Published: August 2021

Menjadi Muslim tidak menjamin seseorang memiliki pengetahuan halal yang memadai. Penggalian ragam pengetahuan halal konsumen Muslim penting karena menjadi dasar keputusan pembelian mereka. Penelitian ini ditujukan untuk menggali rentang pengetahuan halal konsumen Muslim dan kemudian melakukan eksperimen untuk mengkonfirmasinya. Penggalian tersebut dilakukan dengan menyelenggarakan Focus Group Discussion (FGD). Hasil FGD menunjukkan bahwa konsumen Muslim dengan tingkat pengetahuan halal yang minim menggunakan logo halal Majelis Ulama Indonesia (MUI) sebagai dasar menentukan kehalalan produk dalam pengambilan keputusan pembelian. Konsumen dengan pengetahuan halal yang baik menggunakan pertimbangan lain (misalnya proses penyembelihan hewan menyebut nama Allah SWT) ketika tidak menemukan logo halal MUI dalam menentukan kehalalan produk. Hasil eksperimen mengkonfirmasi adanya rentang pengetahuan halal tersebut. Implikasi dari hasil penelitian tersebut adalah perlunya menyertakan halal logo MUI pada produk makanan untuk memudahkan konsumen Muslim membuat keputusan beli.
Computed tomography measured psoas muscle attenuation predicts mortality after transcatheter aortic valve implantation
Authors: Walpot Jeroen , Van Herck Paul , Collas Valerie , Bossaerts Liene , Vandendriessche Tom , Van De Heyning Caroline M. , Heidbuchel Hein , Rodrigus Inez , Bosmans Johan 
Published: August 2021

Aims
The aim of this study was to determine if computed tomography (CT) psoas muscular attenuation measurements may predict all-cause mortality in patients undergoing TAVI.

Methods
Ninety-four consecutive patients undergoing TAVI were analysed. The CT axial slice at the level of the fourth lumbar vertebra was selected. The psoas muscle areas were manually contoured. The circumferential surface area (CSA) of both psoas muscles was determined by selecting the voxels with attenuation values, ranging from 0 to 100 Hounsfield Units (HU). The mean CT attenuation coefficient of the psoas muscle (Psoas mean HU) was measured. The muscle was subdivided into a low-density muscle (LDM) (0–29 HU) and high-density muscle (HDM) (30–100 HU) portion. The HDM/LDM ratio was calculated. We searched for a correlation between HDM/LDM, CSA LDM (%), Psoas mean HU and all-cause mortality.

Results
The mean age was 81.2 ± 7.5 years. Thirty patients had adverse outcome (all-cause mortality). Compared with patients with the lowest CSA LDM (%), patients in the third and second tertiles had an increased hazard ratio for mortality (2.871; 95% confidence interval 0.880–9.371 and 5.044; 95% confidence interval 1.641–15.795, respectively) in a multivariable model with EuroSCORE II, Barthel frailty index and CSA LDM (%) (P = 0.231, 0.097 and 0.019, respectively). HDM/LDM and Psoas mean HU (as continuous variable) were also independent predictors of all-cause mortality (P = 0.019, P = 0.013, respectively)

Conclusion
CSA LDM (%), Psoas mean HU and HDM/LDM are independent and incremental predictors of all-cause mortality in patients undergoing TAVI.
Retrospective comparison of three antivenoms for the treatment of dogs with crotalid envenomation
Authors: Carotenuto Sarah E. , Bergman Philip J. , Ray Jeri R. , McKee Talon 
Published: August 2021

Abstract

OBJECTIVE
To retrospectively compare clinical outcomes associated with 3 commercially available antivenom products (2 F[ab']2 products and 1 IgG product) in dogs with crotalid envenomation.

ANIMALS
282 dogs with evidence of crotalid envenomation treated with antivenom at a single high-volume private emergency facility in southwestern Arizona from 2014 to 2018.

PROCEDURES
Data were collected on all dogs regarding signalment, coagulation test results, snakebite characteristics, type and number of units of antivenom received (1 of 3 products), survival to hospital discharge (yes or no), and complications following discharge. Survival rates and other variables were compared among antivenoms by means of bivariable analyses.

RESULTS
271 of 282 (96.1%) dogs survived to discharge; 11 (3.9%) were euthanized or died in the hospital. No significant difference in survival rates was found among the 3 antivenom products. Infusion reaction rates were higher for the IgG product than for each F(ab')2 product. A higher percentage of dogs treated with the IgG product (vs either F[ab']2 product) received only 1 unit of antivenom. Variables associated with a lower probability of survival included older age and lower body weight, thoracic (vs other) location of snakebites, and presence of an antivenom infusion reaction.

CONCLUSIONS AND CLINICAL RELEVANCE
Given that survival rates were high for all 3 antivenom products, clinicians may consider other factors when selecting an antivenom, such as preference for a fractionated versus whole immunoglobulin product, risk of infusion reaction, cost, shelf life, availability, ease of use and administration, species of crotalids used for antivenom production, approval by federal regulatory bodies, and clinical preference.
Tenure Status in Life Cycle Cohorts in Poland
Authors: Matel Anna 
Published: August 2021

Abstract
Poland is characterized by a relatively high level of homeowners (84% of population in 2018). The preference for ownership, as well as financial possibilities, are not balanced throughout the entire life cycle of a household. The scale of these differences, as well as the tendency to change over time, remains unknown. The subject of conducted research is to indicate how the structure of the tenure status of Poles changes over the life cycle of a household. This publication proposes the division of the household life cycle into the stages of formation, stabilization and reduction. The research on the structure of the tenure status of Poles was conducted for the period of 2006-2018. The analysis showed that, while the share of owner-occupiers increased significantly in Poland in the years 2006-2018, at the stage of forming a household rent begins to prevail. What is more, young people are more likely to choose market rent, and relocation to private housing is associated with having children or getting married. At the same time, there is no tendency to relocate to rented flats at the stage of household reduction in Poland.
A rare case of knee joint mucormycosis with pathological fracture after COVID-19 infection
Authors: Iordache Sergiu Andrei , Cursaru Adrian , Şerban Bogdan , Popa Mihnea Ioan Gabriel 
Published: August 2021

Abstract
Mucormycosis is a fungal infection that generally occurs in patients with some degree of immunosuppression, such as patients with malignancies, diabetes, HIV infection, or patients who require the administration of immunosuppressive drugs.
The final diagnosis is established by collecting some tissue from the infectious process and isolating the fungus using lab cultures.
The treatment of mucormycosis is complex and consists of trying to reduce risk factors, rigorous surgical debridement, and specific antifungal treatment.
We present the case of a 54-year-old male patient with a background of SARS-COV2 infection (moderate form), that started 3 months prior to presentation to our hospital, initially treated at home.
The patient presented to the Orthopaedics Department of the University Emergency Hospital of Bucharest with pain and total functional impotence in his left knee as a result of a trauma that occurred about 2 months before the presentation to the hospital, at that moment with progressive worsening of the symptoms. Clinical and imaging examination established the diagnosis of pathological supra-intercondylar fracture of the left femur.
The purpose of this case report is to present the risk of infection with an opportunistic agent as a result of immunosuppression induced by COVID-19 or its treatment with immunosuppressive agents necessary to combat the inflammatory process. The patient presented with a moderate form of COVID-19 treated at home with nonsteroidal anti-inflammatory drugs and antibiotics to prevent a bacterial superinfection.
Mucormycosis remained a challenging situation for the physician, regardless of his medical specialty, both in terms of diagnosis and treatment. In this case, COVID-19 is one of the risk factors that contributed to the appearance of mucormycosis.
PEMILIHAN TEKNOLOGI PIPA CAHAYA SEBAGAI ALTERNATIF PENCAHAYAAN SIANG HARI PADA BANGUNAN KOMERSIL
Authors: Rofi Willy , Santoso Dermawati Djoko , Poernomo Endhi Ibuhindar 
Published: August 2021

Pencahayaan merupakan salah satu bagian yang penting dalam sebuah ruangan. Tanpa cahaya, manusia akan kurang optimal dalam merasakan suasana ruang.Sejumlah inovasi telah banyak dilakukan untuk menghasilkan alternatif penggganti lampu sebagai sumber cahaya yang hemat energi dengan berbagai cara pengaturan pencahayaannya salah satunya yaitu, teknologi pipa cahaya (Light Pipe). Tulisan ini memaparkan salah satu teknologi pencahayaan yang hemat energi dengan cara mendistibusikan cahaya matahari ke dalam ruangan yang bertujuan untuk menjadi referensi bagi perancang bangunan, khususnya bangunan komersil agar dapat menghemat energi listrik hingga 40%. Metode yang akan digunakan dalam penelitian ini menggunakan pendekatan kualitatif dengan studi literatur. Pengolahan data menggunakan data primer dengan studi preseden. Tulisan ini diharapkan bahwa pipa cahaya ini memiliki potensi yang besar untuk digunakan secara luas di Indonesia.Pencahayaan merupakan salah satu bagian yang penting dalam sebuah ruangan. Tanpa cahaya, manusia akan kurang optimal dalam merasakan suasana ruang.Sejumlah inovasi telah banyak dilakukan untuk menghasilkan alternatif penggganti lampu sebagai sumber cahaya yang hemat energi dengan berbagai cara pengaturan pencahayaannya salah satunya yaitu, teknologi pipa cahaya (Light Pipe). Tulisan ini memaparkan salah satu teknologi pencahayaan yang hemat energi dengan cara mendistibusikan cahaya matahari ke dalam ruangan yang bertujuan untuk menjadi referensi bagi perancang bangunan, khususnya bangunan komersil agar dapat menghemat energi listrik hingga 40%. Metode yang akan digunakan dalam penelitian ini menggunakan pendekatan kualitatif dengan studi literatur. Pengolahan data menggunakan data primer dengan studi preseden. Tulisan ini diharapkan bahwa pipa cahaya ini memiliki potensi yang besar untuk digunakan secara luas di Indonesia.