bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Investigation of spray pyrolyzed cubic structured Cu doped SnS films
Authors: SARICA Emrah 
Published: February 2021

Abstract
In this work undoped and Cu doped SnS film at 4% and 8% were deposited onto glass substrates by spray pyrolysis technique in order to investigate the effect of Cu doping on their physical properties. Surface investigations showed that Cu doping reduced the surface roughness of SnS films from 36.5 nm to 8.8 nm. XRD studies revealed that all films have recently solved large cubic phase of SnS (p-SnS) with a- lattice of 11.53 Å and Cu doping led to reduction in crystallite size from 229 Å to 198 Å. Additionally, all deposited films were found to be under compressive strain. Optical band gaps of SnS:Cu varied in the range of 1.83 eV-1.90 eV. Hall-effect measurements exhibited that all film have p-type conductivity with low hole concentration (~10 11 -10 12 cm -3 ) and high electrical resistivity (~10 4 -10 5 Ωcm).
The Transcription Factor AtGLK1 Acts Upstream of MYBL2 to Genetically Regulate Sucrose-Induced Anthocyanin Biosynthesis in Arabidopsis
Authors: Zhao Dongming , Zheng Yuxuan , Yang lingjun , Yao Ziyu , Cheng Jianfeng , Zhang Fang , Jiang Haiyan , Liu Dong 
Published: February 2021

Abstract
Background: The regulation of anthocyanin biosynthesis by various factors including sugars, light and abiotic stresses is mediated by numerous regulatory factors acting at the transcriptional level. Here experimental evidence was provided in order to demonstrate that the nuclear GARP transcription factor AtGLK1 plays an important role in regulating sucrose-induced anthocyanin biosynthesis in Arabidopsis.Results: The results obtained using real-time quantitative PCR and GUS staining assays revealed that AtGLK1 was mainly expressed in the green tissues of Arabidopsis seedlings and could be induced by sucrose. The loss-of-function glk1 glk2 double mutant has lower anthocyanin levels than the glk2 single mutant, although it has been determined that loss of AtGLK1 alone does not affect anthocyanin accumulation. Overexpression of AtGLK1 enhances the accumulation of anthocyanin in transgenic Arabidopsis seedlings accompanied by increased expression of anthocyanin biosynthetic and regulatory genes. Moreover, we found that AtGLK1 also participates in plastid-signaling mediated anthocyanin accumulations. Genetic, physiological, and molecular biological approaches demonstrated that AtGLK1 acts upstream of MYBL2, which is a key negative regulator of anthocyanin biosynthesis, to genetically regulate sucrose-induced anthocyanin biosynthesis.Conclusion: Our results indicated that AtGLK1 positively regulates sucrose-induced anthocyanin biosynthesis in Arabidopsis via MYBL2.
Deducing insulin producing cells in goat adipose tissue derived mesenchymal stem cells
Authors: Dubey Amit , Malik Hruda Nanda , Kumar Dinesh , Saini Sikander , Kumar Satish , De Arun Kumar , Bhattacharya Debasis , Malakar Dhruba 
Published: February 2021

Abstract
Background: Mesenchymal stem cells (MSCs) is a new herald for regenerative medicine for control of incurable diseases in human and animals. Diabetes occurs when the blood glucose is high due to lack of insulin hormone secreted by the pancreatic cells. The global diabetes in 2019 is estimated 463 million people and rising to 578 million by 2030.
Methods: Here we differentiated goat adipose tissue derived MSCs into insulin producing cells. To achieve this, the goat MSCs were cultured in serum-free DMEM/F12 medium containing glucose, nicotinamide, activin-A, exendin-4, pentagastrin, retinoic acid and mercaptoethanol for three weeks. The in vitro differentiation ADSCs into insulin-producing cells was confirmed by detecting the pancreatic endoderm specific markers i.e. Igf-1, Sst, Ngn3, Pdx-1, Isl-1, c-Kit, Thy-1, and Glut-2 in differentiating cells.
Results: There was a significant increase in insulin specific gene expression with respect to duration of differentiation. Pancreatic insulin-producing cells were further characterized by immunolocalization of Pdx-1, insulin, and Islets-1 specific protein. The release of insulin in response to a glucose challenge was also evaluated.
Conclusions: The study provides new opportunities for deciphering the basic mechanism of in vitro genesis of pancreatic cells and basic properties, availability, and abundance of ADSCs render them well-suited for applications in regenerative medicine.
Item-level monitoring, response style stability, and the hard-easy effect
Authors: Clariana Roy B. , Park Eunsung 
Published: February 2021

Abstract
Cognitive and metacognitive processes during learning depend on accurate monitoring, this investigation examines the influence of immediate item-level knowledge of correct response feedback on cognition monitoring accuracy. In an optional end-of-course computer-based review lesson, participants (n = 68) were randomly assigned to groups to receive either immediate item-by-item feedback (IF) or no immediate feedback (NF). Item-by-item monitoring consisted of confidence self-reports. Two days later, participants completed a retention test (IF = NF, no significant difference). Monitoring accuracy during the review lesson was low, and contrary to expectations was significantly less with immediate feedback (IF < NF, Cohen’s d = .62). Descriptive data shows that (1) monitoring accuracy can be attributed to cues beyond actual item difficulty, (2) a hard-easy effect was observed where item difficulty was related to confidence judgements as a non-monotonic function, (3) response confidence was predicted by the Coh-Metrix dimension Word Concreteness in both the IF and NF treatments, and (4) significant autocorrelations (hysteresis) for confidence measures were observed for NF but not for IF. It seems likely that monitoring is based on multiple and sometimes competing cues, the salience of each relates in some degree to content difficulty, but that the stability of individual response styles plays a substantive role in monitoring. This investigation shows the need for new applications of technology for monitoring multiple measures on the fly to better understand SRL processes to support all learners.
The influence of red blood cell transfusions on the progression-free survival of patients with localized squamous cell carcinoma of the anus treated with definitive chemoradiation
Authors: Zanella C.P. , Camandaroba M. , Mello C.A. , Kayano S. , Donadio M.D. , Riechelmann Rachel 
Published: February 2021

Abstract
Background: Red blood cells transfusions (RBCT) have been associated with worse oncological outcomes in distinct tumor types. Inhibition of the activities of Natural Killer (NK) and cytotoxic T cells are the supposed mechanisms underlying a transfusion-related immune modulation. Because the impact of RBCT on the outcomes of patients with squamous cell carcinoma of the anus (SCCA) is uncertain, we aimed to evaluate its influence on the progression-free survival of patients with SCCA treated with definitive chemoradiation (ChRT). Methodology: This was a retrospective study of consecutive SCCA patients treated with definitive ChRT. The primary endpoint was progression-free survival according to receipt of at least one unit of RBCT. Univariate and multivariate Cox regression analyses for progression-free survival were performed to evaluate prognostic factors. Results: From February 2003 to April 2018, 136 patients were included. The median age was 59 years, 77.2% was female and 13.9% had HIV infection. Transfused patients were more frequently female and had stage III tumors. Thirty-one (22.8%) patients received a RBCT, increasing the mean hemoglobin levels from 7.6 to 8.5g/dl. With a median follow-up time of 48 months, the median progression-free survival was 36.5 versus 146.9 months for transfused and non-transfused, respectively. In the multivariate analysis, RBCT ([HR]: 6.7 [IC] 95% 3.4-13.2, p<0.001) and stage III (HR: 3.0 [IC] 95% 1.4-6.5, p =0.005) were associated with inferior progression-free survival as compared to non-transfused and stage I-II, respectively. While the rates of complete responses and persistent local disease were similar between the groups, receipt of RBCT was significantly associated with progression (69.2% versus 14.9%; p < 0.00001).Conclusion: Our study suggests that the receipt of RBCT and clinical stage III disease were significantly associated with inferior progression free survival. RBCT or persistent anemia after transfusion did not influence the rates of complete response, but patients who received RBCT presented significantly higher rates of tumor progression.
WITHDRAWN: Association of Maternal Serum Zinc, Copper and Magnesium Levels, Pre-pregnancy Body Mass Index and Gestational Weight Gain Patterns With the Risk of Gestational Diabetes Mellitus Among Third-trimester Pregnant Women: a Cross-sectional Study
Authors: Gholizadeh Masoomeh , Rouzitalab Tohid , Ghavamzadeh Saeid , Daneshzad Elnaz 
Published: February 2021

Abstract

Background: This study sought to evaluate the association between selected micronutrients (zinc, copper, and magnesium), pre-pregnancy BMI, and weight gain during pregnancy with the risk of gestational diabetes mellitus third-trimester pregnant women Urmia, Iran. Methods: This analytic cross-sectional study included 400 pregnant women. The nutritional, demographic, clinical data, and fasting blood samples (selected micronutrients and blood glucose) were evaluated. The data were analyzed using chi-square, independent t-test, and logistic regression tests. Results: The prevalence of gestational diabetes mellitus (GDM) was 18%. The OR for GDM was (OR: 0.329; 95% CI: 0.156-0.696) in normal-weight compared to mothers who were obese before pregnancy. Normal serum zinc concentration was associated with 0.413-fold lower rates of developing GDM (95% CI: 0.227-0.750). Magnesium supplementation was inversely associated with the risk of GDM (OR: 0.986; 95% CI: 0.979-0.994). Inadequate and excessive gestational weight gain was significantly associated with developing GDM in lean and obese women before pregnancy, respectively (p=0.01, p=0.003). Conclusions: Gestational diabetes is highly prevalent in Urmia, and it is likely related to excessive serum zinc concentrations, elevated pre-pregnancy BMI, and gestational weight gain.
Safety efficacy and tolerability of the calcitonin gene-related peptide monoclonal antibodies for migraine prevention in a real world setting
Authors: Al-Hashel Jasem Yousef , Alroughani Raed , Ashkanani Hasan Kh , AlMutairi Ohood , Akl Amr , Alwazzan Sawsan , Ahmed Samar Farouk 
Published: February 2021

Abstract
Background:Calcitonin gene-related peptide (CGRP) monoclonal antibodies were approved as preventive treatment for migraine. We aimed to assess CGRP monoclonal antibodies efficacy and safety.Methods:Patients were diagnosed based on International Classification of Headache Disorders disorders-third edition, (ICHD-III). Eligible patients received CGRP monoclonal antibodies (mAbs) and had a follow up visits for at least three months. Primary end point was a 50% or greater reduction in mean migraine days per month at the last visit. Secondary end points were change from baseline to last visit in the mean number of migraine days per month, change in the number of days of use of analgesics, change in the severity of headache pain, and change in scores on the Quality of life (QOL) questionnaire. Safety and tolerability were reported.Results:This prospective study included 63 migraine patients, with a mean age of 44.59 years. Females represented 77.8% of the cohort. A 50% or greater reduction in the mean number of migraine days per month was achieved in 68.3% of patients. At the last visit, patients had a significant reduction in migraine days, number of days of analgesic-usage and the severity of headache (5.13+ 4.11versus 14.04 + 7.77; p < 0.01), (6.43+ 6.34 versus 15.85 +7.31; p <. 0001), (5.40 +2.48 versus 9.67+ 0.72; p < 0.001) respectively. CGRP mAb treatment significantly improved quality of life (112.20+ 12.20 versus 92.13 +15.84; P< 0.001). 14.4% reported adverse events.Conclusion:Prophylactic CGRP monoclonal antibodies treatment for migraine were efficacious and reduced the number of monthly migraine days and the use of days of analgesics.
Amyloid-Beta induces different expression pattern of tissue transglutaminase and its isoforms on Olfactory Ensheathing Cells: modulatory effect of Indicaxanthin
Authors: Campisi Agatina , Raciti Giuseppina , Sposito Giovanni , Grasso Rosaria , Chiacchio Maria A. , Spatuzza Michela , Attanzio Alessandro , Chiacchio Ugo , Tesoriere Luisa , Allegra Mario , Pellitteri Rosalia 
Published: February 2021

Abstract

Alzhèimer Disease (AD) is characterized by protein aggregates in the brain, including amyloid-beta (Aβ), a substrate for tissue transglutaminase (TG2). We assessed the effect of full native peptide of Aβ (1–42), the fragments (25–35 and 35–25) on TG2 expression and its isoforms (Long and Short) on mouse Olfactory Ensheathing Cells (OECs). The levels of cytoskeletal proteins, Vimentin and Glial Fibrillary Acid Protein, were also studied. The effect of the pre-treatment with Indicaxanthin on cell viability, total Reactive Oxygen Species, superoxide anion and apoptotic pathway activation was assessed. Since Nestin is co-expressed in pluripotent stem cells with cyclin D1, their levels were also evaluated. Our findings highlight that Aβ (1–42) and its fragments induced an increase of TG2 levels and the different expression pattern of its isoforms on OECs. Indicaxanthin pre-treatment was able to reduce TG2 over-expression upregulated by Aβ exposure of cells differently modulating its isoforms. In addition, it prevented total Reactive Oxygen Species and superoxide anion production, it reduced Glial Fibrillary Acid Protein and Vimentin levels and inhibited apoptotic pathway activation. It also leaded to an increase of Nestin and cyclin D1 expression, stimulating stem cells renewal through the reparative activity played by TG2. Our results suggest that Aβ in OECs, both in the absence and in the presence of Indicaxanthin, might differently induce the transition of TG2 between “closed” and “open” conformation, providing a new mechanism involved in the signal pathways activated by the protein in Aβ injury important for neural regeneration of AD.
Hydro-biological characterization and efficiency of natural waste stabilization ponds in a desert climate (city of Assa, Southern Morocco)
Authors: Achag Badre , Mouhanni Hind , Bendou Abdelaziz 
Published: February 2021

Abstract
The city of Assa is located in a Saharian area characterized by an arid climate and water scarcity. Like any other Saharian city in a developing country, the city is facing the challenges of rapid urbanization and the need to improve wastewater treatment and management. The main objective of this work is to assess the performance of waste stabilization ponds in an arid area. This evaluation concerns microbiological and physico-chemical monitoring over three and twelve months respectively. Microbiological results indicate bacterial elimination rates of over 90% in autumn–winter due to the effectiveness of facultative ponds with 20–25 days of retention time, water clarity, ponds depth, and high sunlight exposure and penetration. Physico-chemical parameters surpass the Moroccan standards for reuse except Ph and T0 by 20–30%, this wastewater is relatively loaded with various pollutants, especially high organic load and low oxygen content. Statistical analysis has been made by principal component analysis (PCA), and confirms that dissolved oxygen, total suspended solids, COD and BOD5 do not reach the threshold for discharge into the natural environment, and moreover their reuse. For the improvement of the quality of these waters, it is legitimate to provide an upgrade of this plant by a tertiary treatment with maturation ponds.
Identification of Butyrylcholinesterase and Monoamine Oxidase B Targeted Ligands and their Putative Application in Alzheimer’s Treatment: A Computational Strategy
Authors: Jabir Nasimudeen R. , Rehman Md. Tabish , Tabrez Shams , Alserihi Raed F. , AlAjmi Mohamed F. , Khan Mohd Shahnawaz , Husain Fohad Mabood , Ahmed Bakrudeen Ali 
Published: February 2021

Background:With the burgeoning worldwide aging population, the incidence of Alzheimer’s disease (AD) and its associated disorders is continuously rising. To appraise other relevant drug targets that could lead to potent enzyme targeting, 13 previously predicted ligands (shown favorable binding with AChE (acetylcholinesterase) and GSK-3 (glycogen synthase kinase) were screened for targeting 3 different enzymes, namely butyrylcholinesterase (BChE), monoamine oxidase A (MAO-A), and monoamine oxidase B (MAO-B) to possibly meet the unmet medical need of better AD treatment.Materials and Methods:The study utilized in silico screening of 13 ligands against BChE, MAO-A and MAOB using PyRx-Python prescription 0.8. The visualization of the active interaction of studied compounds with targeted proteins was performed by Discovery Studio 2020 (BIOVIA).Results:The computational screening of studied ligands revealed the docking energies in the range of -2.4 to -11.3 kcal/mol for all the studied enzymes. Among the 13 ligands, 8 ligands (55E, 6Z2, 6Z5, BRW, F1B, GVP, IQ6, and X37) showed the binding energies of ≤ -8.0 kcal/mol towards BChE, MAO-A and MAO-B. The ligand 6Z5 was found to be the most potent inhibitor of BChE and MAO-B, with a binding energy of -9.7 and -10.4 kcal mol, respectively. Molecular dynamics simulation of BChE-6Z5 and MAO-B-6Z5 complex confirmed the formation of a stable complex.Conclusion:Our computational screening, molecular docking, and molecular dynamics simulation studies revealed that the above-mentioned enzymes targeted ligands might expedite the future design of potent anti-AD drugs generated on this chemical scaffold.
Polyhedra, Tiles and Graphene Defects: The Case of Tetraoctite
Authors: Elguero José , Alkorta Ibon 
Published: February 2021

:
This mini review concerns hydrocarbons, (CH)n, and carbon allotropes, Cn, and their relationships
with regular solids and regular surfaces, respectively. Platonic and Archimedean solids and
surfaces related to carbon allotropes are described as an introduction. An overview is then provided
on how Stone-Wales defects lead to a series of structures: pentaheptite, Haeckelite, net C, net W,
planar C4, biphenylene, graphyne, graphdiyne, and tetraoctite. This last compound is discussed in
detail together with its relation to the Mills-Nixon effect on cyclooctatetraene (COT).
The Development of Floating Multiple Unit Mini Tablets of Bosentan Using QbD: Characterisation and Pharmacokinetic Study
Authors: Panda Santosh Kumar , Sahu Manoranjan , Panigrahi Kahnu Charan , Patra Chinam Niranjan , Jena Goutam Kumar 
Published: February 2021

Background:
In order to achieve steady state concentration multiple dosing is required for bosentan. Hence formulating bosentan controlled release formulation could be an approach to solve this issue.

Objective:
The objective is to develop floating multiple unit minitablets of bosentan using Quality by design approach.

Methods:
Failure mode effect analysis (FMEA) and Taguchi design are employed in order to
screen highly critical factors. Box-Behnken design (BBD) was adopted for the process of optimization.

Results:
The quantity of gelucire 39/01, HPMC K15 M, and sodium bicarbonate was found to be
one of the significant factors using Taguchi design. The Box-Behnken design results in the optimised
formulation showing floating lag time within 3 min, floating time of nearly 15 h, time to release
50% of drug of 3.6 h, time to release 90% of drug of 11h and better bioavailability compared
to pure drug.

Conclusion:
It can be concluded that floating multiple unit minitablet can be used as an encouraging
approach for sustaining the drug release of bosentan.
Transition from hospital to home during COVID-19: A case report from an Australian transitional care program
Authors: Gough Claire , Hutchinson Claire , Barr Chris , Maeder Anthony , George Stacey 
Published: February 2021

Aim and Background: With the ongoing COVID-19 global pandemic, consideration for vulnerable groups, including our ageing population has been of great concern. Social isolation has been recommended to protect older adults with chronic diseases and reduce the spread of the virus, as well as to prevent healthcare services becoming overwhelmed. Yet social isolation presents its own health risks.
Methods: In this paper, we provide commentary on the lived experience of returning home from hospital during the COVID-19 pandemic. This case report details the experience of an 83-year-old female, who was living and mobilising independently in her own home, prior to hospital admission following a fall and resultant head injury.
Results: The participant returned home during the COVID-19 pandemic with a community transition care program which included assistance with cleaning tasks, shopping, and physiotherapy over a 45-day period.
Conclusions: COVID-19 has illuminated the issue of social isolation and increased awareness of its negative health effects at a global level. As society eases restrictions and returns to a new ‘normal’, many older adults will remain socially isolated. Ongoing allied health intervention is required to ensure quality of life through the latter years and to support older adults through periods of social distancing.
Keywords: transition care; COVID-19, social isolation, community participation
Dacomitinib in first-line treatment of advanced EGFR-mutated non-small-cell lung cancer: a cost–effectiveness analysis
Authors: Aguilar-Serra Javier , Gimeno-Ballester Vicente , Pastor-Clerigues Alfonso , Milara Javier , Marti-Bonmati Ezequiel , Trigo-Vicente Cristina , Cortijo Julio 
Published: February 2021

Aim:
To assess the cost–effectiveness of first-line treatment with dacomitinib compared with gefitinib in patients newly diagnosed with advanced NSCLC
EGFR
-positive in the context of Spain.
Materials & methods:
A partitioned survival model was developed including costs, utilities and disutilities to estimate quality-adjusted life-year (QALY) and incremental cost–effectiveness ratio when treating with dacomitinib versus gefitinib.
Results:
Dacomitinib presented higher QALYs (0.51) compared with gefitinib (0.45). Dacomitinib costs were €33,061 in comparison with €26,692 for gefitinib arm. An incremental cost–effectiveness ratio of €111,048 was obtained for dacomitinib.
Conclusion:
Dacomitinib was more effective in terms of QALYs gained than gefitinib. However, to obtain a cost–effectiveness alternative, a discount greater than 25% in dacomitinib acquisition cost is required.
Determinants and Consequences of Firms' Derivative Accounting Decisions
Authors: Pierce Spencer 
Published: February 2021

ABSTRACT
Financial accounting standards require derivatives to be recognized at fair value with changes in value recognized immediately in earnings. However, if specified criteria are met, firms may use an alternative accounting treatment, hedge accounting, which is intended to better represent the underlying economics of firms' derivative use. Using FAS 161 disclosures, I examine determinants of hedge accounting use and the effects of hedge accounting on financial reporting and capital markets. I find variation in firms' hedge accounting use and provide evidence that compliance costs of applying hedge accounting affect firms' decision to use hedge accounting. Firms decrease their reported earnings volatility via derivatives that receive hedge accounting and could further decrease their earnings volatility if hedge accounting were applied to all their derivatives. Inconsistent with arguments given for using hedge accounting, I fail to find a decrease in investors' assessments of firm risk from using hedge accounting.
JEL Classifications: M40; M41; G32.