bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trypan blue induced teratogenesis of rat embryos cultivated in vitro
Authors: Turbow M. M. 
Published: April 2021

ABSTRACT
Trypan blue is known to produce embryonic abnormalities in a wide variety of animals, including rats (Gillman, Gilbert, Gillman & Spence, 1948), mice (Waddington & Carter, 1953; Hamburgh, 1954), amphibians (Waddington & Perry, 1956), chickens (Beaudoin & Wilson, 1958;Stéphan & Sutter, 1961), rabbits (Ferm, 1956), and hamsters (Ferm, 1958). Studies on the teratogenic action of this dye have also been made in culture (Mulherkar, 1960).
Conceptualizing Medical Resident’s Journey through Wonderland of Clinical Practice: From transitional shock to role adaptation to independent practice
Authors: Sohail Marium , Yasmeen Rahila 
Published: April 2021

Objectives: To explore experiences of medical residents about stages and nature of transitional journey from induction into residency program to achievement of consultant title.
Methods: Qualitative phenomenological study was conducted at Sir Gangaram hospital and Fatima Memorial Hospital, Lahore for six months from Feb 2019-July 2019 after IRB/ERC approval from Islamic International Medical College (Ref# Riphah/IIMC/ERC/19/0320). Using purposive criterion sampling, 16 semi-structured interviews in four departments, four strata of junior residents, senior residents, newly-qualified consultants, and supervising consultants with four participants each were conducted till theoretical saturation of data was achieved. After informed consent, audio recorded data was transcribed verbatim & analyzed through Atlas.ti 7 using Interpretive Phenomenological Analysis. After Bracketing and horizontalization, data was coded line by line. Codes (324) were merged to categories (19) for structural and textural description. Composite description of phenomenon was done by abstraction of themes (eight for stages and two for nature of journey).
Results: Eight themes for stages as merriment, anguish, melancholy, acceptance and efforts, intensive learning, burnishing to shine, identity formation and intra-stage oscillations were identified. Two themes for journey’s nature were exponential learning & oscillating journey.
Conclusion: The transitional journey is a multi-stage complex, oscillating journey. An oscillating electron model is presented upon the findings of this study to explain resident transition
doi: https://doi.org/10.12669/pjms.37.4.3853
How to cite this:Sohail M, Yasmeen R. Conceptualizing Medical Resident’s Journey through Wonderland of Clinical Practice: From transitional shock to role adaptation to independent practice. Pak J Med Sci. 2021;37(4):1048-1053. doi: https://doi.org/10.12669/pjms.37.4.3853
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Clinical outcomes of maitland mobilization in patients with Myofascial Chronic Neck Pain: A randomized controlled trial
Authors: Shabbir Maryam , Arshad Naveed , Naz Anam , Saleem Nadia 
Published: April 2021

Background and Objective: Myofascial neck pain is a common musculoskeletal problem caused by presence of trigger points and local and referred pain patterns. Chronic neck pain is responsible for the involvement of joints, ligaments, fascia and connective tissue as well. The objective of this study was to assess the effect of Maitland mobilization in patients with myofascial chronic neck pain.
Methods: In this randomized, placebo treatment-controlled trial, 30 patients consecutively aged 25-45 years meeting inclusion criteria were isolated into two groups. The study group was treated with Maitland mobilization consistently for eight weeks while the control group got placebo treatment for a similar timeframe. Visual analog Scale (VAS), Neck disability index (NDI) and cervical range of motion (ROM) questionnaire was filled by patients before, intermediate and after the intervention to evaluate the severity of pain, functional ability and range of motion.
Results: Following eight weeks of treatment, when compared the post treatment effects of both groups, the significance value for VAS was 0.008, for NDI p=0.030, for Flexion p=0.573, for extension p=0.001, for right rotation p<0.001, for left rotation p=0.002, for right and left side bending p<0.001.
Conclusion: The study concluded that Maitland mobilization grades (I-IV) are effective in reducing pain and improving functional level of NDI scale and the ranges of cervical spine in patients with myofascial chronic neck pain.
doi: https://doi.org/10.12669/pjms.37.4.4220
How to cite this:Shabbir M, Arshad N, Naz A, Saleem N. Clinical outcomes of maitland mobilization in patients with Myofascial Chronic Neck Pain: A randomized controlled trial . Pak J Med Sci. 2021;37(4):1172-1178. doi: https://doi.org/10.12669/pjms.37.4.4220
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Thoughts on the potential to compensate a hearing loss in noise
Authors: Schädler Marc René 
Published: April 2021

Background: The effect of hearing impairment on speech perception was described by Plomp (1978) as a sum of a loss of class A, due to signal attenuation, and a loss of class D, due to signal distortion. While a loss of class A can be compensated by linear amplification, a loss of class D, which severely limits the benefit of hearing aids in noisy listening conditions, cannot. The hearing loss of class D is assumed to be the main reason why not few users of hearing aids keep complaining about the limited benefit of their devices in noisy environments. Working compensation strategies against it are unknown. Methods: Recently, in an approach to model human speech recognition by means of a re-purposed automatic speech recognition (ASR) system, the loss of class D was explained by introducing a level uncertainty which reduces the individual accuracy of spectro-temporal signal levels. Based on this finding, an implementation of a patented dynamic range manipulation scheme (PLATT) is proposed which aims to mitigate the effect of increased level uncertainty on speech recognition in noise by expanding spectral modulation patterns in the range of 2 to 4 ERB. This compensation approach is objectively evaluated regarding the benefit in speech recognition thresholds in noise using the ASR-based speech recognition model. Recommendations for an evaluation with human listeners are derived. Results: The objective evaluation suggests that approximately half of the class D loss due to an increased level uncertainty might be compensable. To measure the effect with human listeners, an experiment needs to be carefully designed to prevent the confusion class A and D loss compensations. Conclusions: A working compensation strategy for the class D loss could provide previously unexploited potential for relief. Evidence has to be provided in experiments with human listeners.
The Dilemmas of Flexibilisation of Vocational Education and Training: A Case Study of the Piano Makers
Authors: Baumeler Carmen , Engelage Sonja , Strebel Alexandra 
Published: April 2021

Context: Dual VET systems are often praised for their labour market proximity because of economic stakeholders’ involvement. However, when labour market requirements change rapidly, a lack of flexibility is attributed to them. This occurs in times of fast socio-technological change like the current digital transformation. A repeatedly proposed measure to increase system flexibility is to reduce the number of occupations and create broader occupational profiles, for example, by combining similar occupations into so-called occupational fields. However, little is known about actually establishing occupational fields.Approach: Against this backdrop, we address the following research question: How was an occupational field created? As Switzerland attempted to merge occupations over a decade ago, we selected an information-rich and illuminative case concerning the research question: The piano makers’ occupation as one of the first occupations required to merge into an occupational field called musical instrument makers together with organ builders and wind instrument makers. Based on a qualitative case study, we reconstruct the process of occupational field construction by combining expert interviews with comprehensive document analysis and present its narrative.Findings: Based on this case study, we contribute to the understanding of VET flexibilisation by detailing occupational field creation and identifying opportunities and challenges. Here, we pay special attention to the institutional work of the affected occupational association and identify the importance of preserving its collective occupational identity. Although regulatory changes disrupted the piano makers’ occupation, the occupational association reinstitutionalised it as part of the musical instrument makers’ occupational field. Over a decade later, the piano makers reintroduced their former occupational title, which is deeply connected to their occupational identity. Conclusion: The results indicate that VET reforms that promote flexibilisation by creating occupational fields encounter serious limitations in collectively governed dual VET systems. In the Swiss system, occupational associations are core collective actors that rely on their members’ voluntary work. To maintain these economic stakeholders’ necessary commitment to VET, their collective occupational identity, symbolized by their long-standing occupational title, needs to be preserved.
Co-located angularly offset fiber Bragg grating pair for temperature-compensated unambiguous 3D shape sensing
Authors: Feng Dingyi , Albert Jacques , Hou Yueguo , Jiang Biqiang , Jiang Yajun , Ma Ying , Zhao Jianlin 
Published: April 2021

A 10 mm-long three-dimensional shape sensor in a single-mode fiber is described and demonstrated experimentally. The sensor is based on a pair of fiber Bragg gratings inscribed at the same location along the fiber axis but offset along different radial directions away from the fiber center. Each offset grating generates cladding mode resonances over a

∼

20

n
m

-wide spectral bandwidth, and the two gratings are also offset in period so that their transmission spectra are separated by 40 nm, and thus non-overlapping and fully distinguishable. Directional bending sensitivity results from the differential amplitude response of the cladding mode resonances from the two gratings, depending on the relative orientation of the bend with the azimuthal direction of the grating offsets. It is further demonstrated that both axial deformation and temperature have no influence on the shape measurement as they both only cause a global wavelength shift of the spectra without amplitude change. The experimental results demonstrate that the shape orientation of an object can be unambiguously determined for bend directions covering the full 360° range around the fiber axis with sensitivities of the order of

1

d
B

/

m

−
1

and small curvatures between 0 and

1

m

−
1

.
Maternal and perinatal mortality and morbidity of uterine rupture and its association with prolonged duration of operation in Ethiopia: A systematic review and meta-analysis
Authors: Desta Melaku , Kassa Getachew Mullu , Getaneh Temesgen , Sharew Yewbmirt , Alemu Addisu Alehegn , Birhanu Molla Yigzaw , Yeneabat Tebikew , Alamneh Yoseph Merkeb , Amha Haile 
Published: April 2021

Background
Uterine rupture is the leading cause of maternal and perinatal morbidity and it accounts for 36% of the maternal mortality in Ethiopia. The maternal and perinatal outcomes of uterine rupture were inconclusive for the country. Therefore, this systematic review and meta-analysis aimed to estimate the pooled maternal and perinatal mortality and morbidity of uterine rupture and its association with prolonged duration of operation.

Methods
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist was used for this systematic review and meta-analysis. We systematically used PubMed, Cochrane Library, and African Journals online databases for searching. The Newcastle- Ottawa quality assessment scale was used for critical appraisal. Egger’s test and I2 statistic used to assess the check for publication bias and heterogeneity. The random-effect model was used to estimate the pooled prevalence and odds ratios with 95% confidence interval (CI).

Results
The pooled maternal mortality and morbidity due to uterine rupture in Ethiopia was 7.75% (95% CI: 4.14, 11.36) and 37.1% (95% CI: 8.44, 65.8), respectively. The highest maternal mortality occurred in Southern region (8.91%) and shock was the commonest maternal morbidity (24.43%) due to uterine rupture. The pooled perinatal death associated with uterine rupture was 86.1% (95% CI: 83.4, 89.9). The highest prevalence of perinatal death was observed in Amhara region (91.36%) and the lowest occurred in Tigray region (78.25%). Prolonged duration of operation was a significant predictor of maternal morbidity (OR = 1.39; 95% CI: 1.06, 1.81).

Conclusions
The percentage of maternal and perinatal deaths due to uterine rupture was high in Ethiopia. Uterine rupture was associated with maternal morbidity and prolonged duration of the operation was found to be associated with maternal morbidities. Therefore, birth preparedness and complication readiness plan, early referral and improving the duration of operation are recommended to improve maternal and perinatal outcomes of uterine rupture.
What gaps remain in the HIV cascade of care? Results of a population-based survey in Nsanje District, Malawi
Authors: Conan Nolwenn , Paye Cyrus P. , Ortuno Reinaldo , Chijuwa Alexander , Chiwandira Brown , Goemaere Eric , Belen Garone Daniela , Coulborn Rebecca M. , Chihana Menard , Maman David 
Published: April 2021

Introduction
The Malawi Ministry of Health (MoH) has been in collaboration with Médecins sans Frontières (MSF) to increase access to quality HIV care through decentralization of antiretroviral therapy (ART) diagnosis and treatment from hospital to clinics in Nsanje District since 2011. A population-based household survey was implemented to provide information on HIV prevalence and cascade of care to inform and prioritize community-based HIV interventions in the district.

Methods
A cross-sectional survey was conducted between September 2016 and January 2017. Using two-stage cluster sampling, eligible adult individuals aged ≥15 years living in the selected households were asked to participate. Participants were interviewed and tested for HIV at home. Those tested HIV-positive had their HIV-RNA viral load (VL) measured, regardless of their ART status. All participants tested HIV-positive at the time of the survey were advised to report their HIV test result to the health facility of their choice that MSF was supported in the district. HIV-RNA VL results were made available in this health facility.

Results
Among 5,315 eligible individuals, 91.1% were included in the survey and accepted an HIV test. The overall prevalence was 12.1% (95% Confidence Interval (CI): 11.2–13.0) and was higher in women than in men: 14.0% versus 9.5%, P<0.001. Overall HIV-positive status awareness was 80.0% (95%CI: 76.4–83.1) and was associated with sex (P<0.05). Linkage to care was 78.0% (95%CI: 74.3–81.2) and participants in care 76.2% (95%CI: 72.4–79.5). ART coverage among participants aware of their HIV-positive status was 95.3% (95%CI: 92.9–96.9) and was not associated with sex (P = 0.55). Viral load suppression among participants on ART was 89.9% (95%CI: 86.6–92.4) and was not statistically different by sex (p = 0.40).

Conclusions
Despite encouraging results in HIV testing coverage, cascade of care, and UNAIDS targets in Nsanje District, some gap remains in the first 90, specifically among men and young adults. Enhanced community engagement and new strategies of testing, such as index testing, could be implemented to identify those who are still undiagnosed, particularly men and young adults.
Palliative care needs and preferences of female patients and their caregivers in Ethiopia: A rapid program evaluation in Addis Ababa and Sidama zone
Authors: Kaba Mirgissa , de Fouw Marlieke , Deribe Kalkidan Solomon , Abathun Ephrem , Peters Alexander Arnold Willem , Beltman Jogchum Jan 
Published: April 2021

Introduction
In Ethiopia there is an extensive unmet need for palliative care, while the burden of non-communicable diseases and cancer is increasing. This study aimed to explore palliative care needs and preferences of patients, their caregivers, and the perspective of stakeholders on service provision in palliative programs for women, mostly affected by cervical cancer and breast cancer.

Methods
A rapid program evaluation using a qualitative study approach was conducted in three home-based palliative care programs in Addis Ababa and Yirgalem town, Ethiopia. Female patients enrolled in the programs, and their primary caregivers were interviewed on palliative care needs, preferences and service provision. We explored the views of purposely selected stakeholders on the organization of palliative care and its challenges. Audio-taped data was transcribed verbatim and translated into English and an inductive thematic analysis was applied. Descriptive analyses were used to label physical signs and symptoms using palliative outcome scale score.

Results
A total of 77 interviews (34 patients, 12 primary caregivers, 15 voluntary caregivers, 16 stakeholders) were conducted. The main physical complaints were moderate to severe pain (70.6%), followed by anorexia (50.0%), insomnia, nausea and vomiting (41.2%). Social interaction and daily activities were hampered by the patients’ condition. Both patients and caregivers reported that programs focus most on treatment of symptoms, with limited psychosocial, emotional, spiritual and economic support. Lack of organizational structures and policy directions limit the collaboration between stakeholders and the availability of holistic home-based palliative care services.

Conclusions
Although female patients and caregivers appreciated the palliative care and support provided, the existing services did not cover all needs. Pain management and all other needed supports were lacking. Multi-sectorial collaboration with active involvement of community-based structures is needed to improve quality of care and access to holistic palliative care services.
Birth preparedness and complication readiness practice and associated factors among pregnant women in Northwest Ethiopia: 2018
Authors: Debelie Tibeb Zena , Abdo Abdella Amano , Anteneh Kiber Temesgen , Limenih Miteku Andualem , Asaye Mengstu Melkamu , Lake Aynalem Getie , Ambaw Worku Mequannt , Kassie Belayneh Ayanaw , Abebe Solomon Mekonnen 
Published: April 2021

Background
Birth-preparedness and complication readiness is a comprehensive strategy aimed at promoting the timely utilization of skilled maternal and neonatal health care. Pregnancy-related complications both on the mother and the newborn could be largely alleviated if there is a well-consolidated birth preparedness and complication readiness plan developed during pregnancy and implemented at the time of delivery.

Objective
To determine the prevalence of birth preparedness and complication readiness practice (BPCR) and associated factors among pregnant women in North Gondar Zone, Northwest Ethiopia, 2018.

Methods
A community based cross-sectional study was conducted among pregnant women in North Gondar Zone from March 2017 to February 2018. A multistage clustered sampling technique was used to enroll a total of 1620 participants. The data were collected by face to face interviews using pretested and semi-structured questionnaires at baseline and following delivery. The data were entered using EPI-data version 3.1 and analyzed using STATA version 14 software. Bivariate and multivariable logistic regression model was fitted to assess factors with BPCR practice. Adjusted odds ratio (AOR) with 95% confidence interval was used to determine the association between covariates and the outcome variable.

Results
From a total of 1620 pregnant women only 1523 (94.0%) mothers were followed at the end line. The prevalence of BPCR plan during pregnancy was 66.1% [95% CI: 63.8, 68.5] and the practice at the time of delivery was 73.5% [95% CI 71.3, 75.7]. Of the total respondents who mentioned having a BPCR plan, 76.4% practiced at the time of delivery. Frequency of ANC visits [AOR = 1.97; 95% CI: 1.67, 2.32], larger number of family in the household [AOR = 1.14; 95%CI: 1.00, 1.30], highest wealth asset [AOR = 1.87; 95%CI: 1.16, 3.01], Multigravidity [AOR = 0.30; 95% CI: 0.15, 0.62], husband involvement in decision making [AOR = 2.2; 95% CI: 1.25, 3.82], counseled on BPCR [AOR = 2.35; 95% CI: 1.51, 3.68], were found to be significantly associated with BPCR practice.

Conclusion
BPCR practice at the time of delivery was higher than previous studies conducted in the country. However, BPCR practice was found to be lower than the standard that every woman should practice the plan at the time of delivery. Intersectoral collaborative interventions required to improve the economic status and living standard of families in the community as well as various awareness creation strategies should be implemented to support women to attend ANC follow-up visits.
Image-derived mean velocity measurement for prediction of coronary flow reserve in a canonical stenosis phantom using magnetic particle imaging
Authors: Siepmann Robert , Nilius Henning , Mueller Florian , Mueller Katrin , Luisi Claudio , Dadfar Seyed Mohammadali , Straub Marcel , Schulz Volkmar , Reinartz Sebastian Daniel 
Published: April 2021

Introduction
Aim of this study is to evaluate whether magnetic particle imaging (MPI) is capable of measuring velocities occurring in the coronary arteries and to compute coronary flow reserve (CFR) in a canonical phantom as a preliminary study.

Methods
For basic velocity measurements, a circulation phantom was designed containing replaceable glass tubes with three varying inner diameters, matching coronary-vessel diameters. Standardised boluses of superparamagnetic-iron-oxide-nanoparticles were injected and visualised by MPI. Two image-based techniques were competitively applied to calibrate the respective glass tube and to compute the mean velocity: full-duration-at-half-maximum (FDHM) and tracer dilution (TD) method. For CFR-calculation, four necessary settings of the circulation model of a virtual vessel with an inner diameter of 4 mm were generated using differently sized glass tubes and a stenosis model. The respective velocities in stenotic glass tubes were computed without recalibration.

Results
On velocity level, comparison showed a good agreement (rFDHM = 0.869, rTD = 0.796) between techniques, preferably better for 4 mm and 6 mm inner diameter glass tubes. On CFR level MPI-derived CFR-prediction performed considerably inferior with a relative error of 20–44%.

Conclusions
MPI has the ability to reliably measure coronary blood velocities at rest as well as under hyperaemia and therefore may be suitable for CFR calculation. Calibration-associated accuracy of CFR-measurements has to be improved substantially in further studies.