P–246 Oocyte degeneration after ICSI is not an indicator of live birth in young women
Authors: Hu X , Xu Y 
Published: August 2021

Abstract

Study question
To investigate whether oocyte degeneration after intracytoplasmic sperm injection (ICSI) is an indicator for predicting the cumulative live birth rate.

Summary answer
The presence of oocyte degeneration after ICSI is not an indicator for predicting the cumulative live birth rate per OPU cycle in young women.

What is known already
Oocyte degeneration may be associated with decreased embryo quality for embryo development kinetics was disturbed. No differences in clinical outcomes such as implantation rate or clinical pregnancy rate were found in fresh embryo transfer cycles in retrospective studies.

Study design, size, duration
This was a retrospective cohort study, including all the oocyte retrieval cycles from young women who underwent ICSI from January 2018 to December 2019 at the Reproductive Medicine Center of the First Affiliated Hospital of Sun Yat-sen University.

Participants/materials, setting, methods
The inclusion criteria were as follows: female age was younger than 35 years; the first or second oocyte retrieval cycles ;the number of oocyte retrieval was between 8 and 20; all the cycles performed fresh embryo transfer on day 3 after insemination. Cycles with at least one oocyte degenerated after ICSI were defined as the oocyte degeneration group (OD group), and cycles with no oocyte degenerated after ICSI were defined as the non-OD group

Main results and the role of chance
There were no significant differences with regards to implantation rate (38.5% vs 35.1%, P = 0.302), clinical pregnancy rate (54.9% vs 50.3%, P = 0.340), and live birth rate per OPU cycle (47.0% vs 42.9%, P = 0.395) between OD and non-OD groups. Initial gonadotropin dosage, E2 level on hCG day and the number of matured oocytes appeared to be independent risk factors for OD, after adjustment for female age, female BMI, duration of gonadotropin administration, FORT, number of retrieved oocytes and different technicians. The adjusted odds ratio of live birth rate per OPU cycle were similar in subgroups with different oocyte degeneration rates. The ongoing pregnancy/live birth rate per transfer in FET cycles was not significantly different between OD group and non-OD groups (38.8% vs 43.9%, P = 0.439). The cumulative live birth rate per OPU cycle was also comparable between the OD group and non-OD group (63.4% vs 64.8%, P = 0.760).

Limitations, reasons for caution
The time interval for the follow-up was not long enough for all the frozen embryos to be transferred. Moreover, the retrospective nature of the study introduces the potential to include confounding variables that may bias our results, although we performed multiple logistic regression analysis to minimize these effects.
Wider implications of the findings: The presence of oocyte degeneration is not an indicator for predicting the cumulative live birth rate per OPU cycle in young women. Initial gonadotropin dosage, E2 level on hCG day and the number of matured oocytes appeared to be independent risk factors for oocyte degeneration.

Trial registration number
none