bluuebunny/crossref_metadata_2025_split huggingface dataset:
Materials Beyond Conventional Triboelectric Series for Fabrication and Applications of Triboelectric Nanogenerators
Authors: Khandelwal Gaurav , Maria Joseph Raj Nirmal Prashanth , Kim Sang‐Jae 
Published: July 2021

AbstractTriboelectric nanogenerators (TENGs) were first developed in 2012, and have become the desirable choice as energy harvesters in the research community worldwide. The popularity of TENGs is attributed to their low weight, low cost, high output, wide range of materials and device designs. TENGs have been explored for many applications including sensing, implantable power sources, healthcare, and biomedical applications. The performance of TENGs depends largely on the material since charge density (σ) is a material property. Moreover, 2D materials have been investigated as an alternative to the conventional metal electrodes. The dominance of polymers and metals in the traditional triboelectric series has lead researchers to explore novel materials to extend the applications and improve TENG output. This review article summarizes the progress in the development of frictional layers and electrode materials for TENGs. The mechanism for the output enhancement and device applications are discussed in detail. Finally, a perspective on the future and relevant challenges in material development for TENGs are discussed.
Clinical implications of SRSF2 mutations in AML patients undergoing allogeneic stem cell transplantation
Authors: Grimm Juliane , Jentzsch Madlen , Bill Marius , Backhaus Donata , Brauer Dominic , Küpper Johannes , Schulz Julia , Franke Georg‐Nikolaus , Vucinic Vladan , Niederwieser Dietger , Platzbecker Uwe , Schwind Sebastian 
Published: July 2021

AbstractThe SRSF2 mutations are frequently found in acute myeloid leukemia (AML) and mostly affect the P95 residue. Mutations in this splicing factor mediate abnormal splicing associated with exon skipping events, including EZH2 as a crucial target. While SRSF2 mutations are enriched in secondary AML and associated with worse outcomes following chemotherapy consolidation, very little is known about the associated biological and clinical implications in AML patients consolidated with allogeneic hematopoietic stemcell transplantation (HSCT). Here we retrospectively analyzed 263 adult AML patients who received an allogeneic HSCT regarding the biological and clinical implications of the SRSF2 mutation status at diagnosis and in morphologic remission at HSCT. We found 12.5% of the patients to be SRSF2 mutated at diagnosis. Mutated patients had increased EZH2 missplicing events with P95H likely driving this pathobiology most effectively. However, the amount of EZH2 missplicing events, as a functional surrogate marker did not associate with relevant biological or clinical characteristics. We observed a persistence of mutations in remission before HSCT in the majority (93%) of SRSF2 mutated AML patients. Importantly, the variant allele frequency (VAF) levels of SRSF2 mutations in remission at HSCT did not correlate with outcomes following HSCT consolidation, limiting the applicability of SRSF2 mutations as a marker for residual AML disease. Following allogeneic HSCT SRSF2 mutated AML patients experienced a 2‐year overall survival of 77%, indicating that SRSF2 mutated AML patients may benefit from HSCT consolidation.
Thermal antioxidative kinetics of sesamol in triacylglycerols and fatty acid methyl esters of sesame, olive, and canola oils
Authors: Toorani Mohamad Reza , Farhoosh Reza , Golmakani Mohamad‐Taghi , Sharif Ali 
Published: July 2021

AbstractOxidation kinetics of the triacylglycerols (TAGs) and fatty acid methyl esters (FAMEs) of sesame, olive, and canola oils were studied in the presence of the different concentrations of sesamol (0.1%–0.16%) at 60, 80, and 100°C. Sesamol increased the temperature coefficient, TC, and Q10 number of the TAGs more significantly compared to the FAMEs. All the sesamol‐added TAG and FAME systems, respectively, of the olive, canola, and sesame oils, respectively, exerted increased values of the Arrhenius (activation energy, Ea, and frequency factor, A) and Eyring (enthalpy, ΔH++, and entropy, ΔS++) equation parameters. Sesamol improved the Gibbs free energy (ΔG++) of the activated complex formation in the canola, sesame, and olive systems, respectively, and the effect was greater in the FAMEs.
Mechanical performance and supermolecular morphology of void free polypropylene manufactured by fused filament fabrication
Authors: Huang Miaozi , Xu Yao , Schlarb Alois K. 
Published: July 2021

AbstractIt is known from the literature that freedom from macroscopic defects (voids) is an essential prerequisite for good mechanical properties of 3D‐printed components manufactured using fused filament fabrication. The present study further shows that the morphology and mechanical properties of void free components are significantly influenced by the choice of process parameters. Components that were printed at low temperatures and high speeds show fair and inhomogeneous supermolecular morphology, clearly visible weld seams and a special flow‐induced staggered structure of the individual strands laid‐up. At higher magnification in the optical microscope, transcrystalline structures are visible starting from the contact area between the strands, that is, crystallization has started at the interface between the strands and is moving forward towards the center of the strands. In contrast, the samples printed at high temperatures and low speeds show a homogeneous supermolecular morphology with overall larger spherulites and a higher degree of crystallinity and compared to the specimens printed with the low temperature/high speed‐set much better mechanical properties. A numerical simulation of the temperature at the contact point of the strand emerging from the hot nozzle and the cooled strand neighbor agrees well with the measured behavior. The thermal simulation thus enables the temperature to be calculated at any point in time in the welding contact and thus access to the local thermal conditions during joining, cooling and the formation of the morphology.
Factorial validity of the Theory of Mind Inventory‐2 in children with autism spectrum disorder
Authors: Lee Shih‐Chieh , Tsai Ching‐Hong , Lin Yu‐Ching , Li Hsing‐Jung , Jiang Dai‐Rong , Fu I‐Ning , Chen Kuan‐Lin 
Published: July 2021

AbstractThe Theory of Mind Inventory‐2 appears to be a promising measure assessing children's theory of mind. However, a lack of evidence on its factorial structure interferes with score interpretation. To examine whether the currently‐available structures of the Theory of Mind Inventory‐2 are robust and replicable, confirmatory factor analysis was conducted in 242 children with autism spectrum disorder aged 3–12 years. Two possible structures were examined: the development‐based structure, which reflects children's developmental stages of theory of mind (early, basic, and advanced), and the content‐based structure, which represents children's social‐related functions (emotion recognition, mental state term comprehension, and pragmatics). Four fit indices were adopted simultaneously to examine the model fit of both structures. We found that the development‐based structure had a better model fit and was further modified. After modification, the development‐based structure showed an improved model fit, but it was not completely acceptable in all fit indices. These findings suggest that the scores of the Theory of Mind Inventory‐2 are more appropriate for reflecting children's developmental stages of theory of mind than the social‐related functions in children with autism spectrum disorder. However, the domain scores should be cautiously interpreted because the model fits were not completely acceptable. For further revisions, ambiguous terms (e.g., “want” and “need”) and confusing concepts assessed by the items (e.g., “recognize” and “understand”) could be specified for a better representation of children's developmental stages of theory of mind. Moreover, further validations are needed.Lay SummaryIn children with autism spectrum disorder, the scores of the Theory of Mind Inventory‐2 are more appropriate for indicating the developmental stages of theory of mind (early, basic, and advanced) than for indicating the social‐related functions (emotion recognition, mental state term comprehension, and pragmatics). However, since the factorial validity was not completely acceptable, the domain scores should be interpreted cautiously. Moreover, further revisions and validations are warranted.
The evaluation of global cognitive and emotional status of older patients with chronic tinnitus
Authors: Fetoni Anna Rita , Di Cesare Tiziana , Settimi Stefano , Sergi Bruno , Rossi Giorgia , Malesci Rita , Marra Camillo , Paludetti Gaetano , De Corso Eugenio 
Published: July 2021

AbstractObjectivesTinnitus is a common symptom largely impactful on quality of life, especially in the elderly. Our aim was to evaluate the efficacy of self‐administered screening tests to correlate the severity of subjective perception of tinnitus with emotional disorders and the overall cognitive status.MethodsPatients aged ≥ 55 years with chronic tinnitus were recruited and submitted to a complete audiological evaluation; Tinnitus Handicap inventory (THI); Hospital Anxiety and Depression Scale (HADS‐A and HADS‐D) and Mini‐Mental State Examination (MMSE). Demographic and audiological features of patients with and without cognitive impairment (MMSE score cut‐off of 24/30) were analyzed in order to reveal the relationship among tinnitus, emotional disorders, and cognitive dysfunction.Results102 patients were recruited (mean age: 70.4 ± 9.6). THI score was directly related to HADS‐A score (r = .63) HADS‐D score (r = .66), whereas there was no relationship between tinnitus severity and MMSE (r = .13). CI and n‐CI groups did not differ in the characteristics of tinnitus (p > .05), however, hearing threshold (p = .049) and anxious depressive traits measured with HADS‐A (p = .044) and HADS‐D (p = .016) were significantly higher in the group with cognitive impairment. Furthermore, age ≥ 75 years (p = .002, OR = 13.8), female sex (p = .032; OR = 6.5), severe hearing loss (p = .036; OR = 2.3), and anxiety (p = .029; OR = 9.2) resulted risk factors for CI. Therefore, in CI group MMSE score was inversely related to age (r = −.84).ConclusionsCognitive impairment and psychiatric discomfort should be considered in tinnitus patients, related to increasing age, female sex, and severe hearing loss. Thus, self‐administered questionnaires can be useful in addressing clinical approach.
Understanding the effect of market orientation on circular economy practices: The mediating role of closed‐loop orientation in German SMEs
Authors: Schmidt Corinna Vera Hedwig , Kindermann Bastian , Behlau Cassian Felix , Flatten Tessa Christina 
Published: July 2021

AbstractThe implementation of circular economy (CE) practices is considered a key driver towards sustainable development of firms. Earlier studies point to the general strategic approach of market orientation as an antecedent to CE practice implementation. Still, insights are limited as the mechanisms underlying this relationship remain unclear. Based on a sample of 121 German small and medium‐sized enterprises (SME), we empirically examine how the strategic approach of closed‐loop orientation mediates the relationship between market orientation and the implementation of three types of CE practices. Using structural equation modelling, we find that while market orientation is positively related to all three types of CE practices, closed‐loop orientation mediates these relationships for only two. Our study extends CE literature by suggesting that market orientation is translated into closed‐loop orientation to spur CE practice implementation. We also offer a differentiated understanding of CE practice implementation in the context of German SMEs.
Perception versus reality: A National Cohort Analysis of the surgery‐first approach for resectable pancreatic cancer
Authors: Bergquist John R. , Thiels Cornelius A. , Shubert Christopher R. , Ivanics Tommy , Habermann Elizabeth B. , Vege Santhi S. , Grotz Travis E. , Cleary Sean P. , Smoot Rory L. , Kendrick Michael L. , Nagorney David M. , Truty Mark J. 
Published: July 2021

AbstractIntroductionAlthough surgical resection is necessary, it is not sufficient for long‐term survival in pancreatic ductal adenocarcinoma (PDAC). We sought to evaluate survival after up‐front surgery (UFS) in anatomically resectable PDAC in the context of three critical factors: (A) margin status; (B) CA19‐9; and (C) receipt of adjuvant chemotherapy.MethodsThe National Cancer Data Base (2010–2015) was reviewed for clinically resectable (stage 0/I/II) PDAC patients. Surgical margins, pre‐operative CA19‐9, and receipt of adjuvant chemotherapy were evaluated. Patient overall survival was stratified based on these factors and their respective combinations. Outcomes after UFS were compared to equivalently staged patients after neoadjuvant chemotherapy on an intention‐to‐treat (ITT) basis.ResultsTwelve thousand and eighty‐nine patients were included (n = 9197 UFS, n = 2892 ITT neoadjuvant). In the UFS cohort, only 20.4% had all three factors (median OS = 31.2 months). Nearly 1/3rd (32.7%) of UFS patients had none or only one factor with concomitant worst survival (median OS = 14.7 months). Survival after UFS decreased with each failing factor (two factors: 23 months, one factor: 15.5 months, no factors: 7.9 months) and this persisted after adjustment. Overall survival was superior in the ITT‐neoadjuvant cohort (27.9 vs. 22 months) to UFS.ConclusionDespite the perceived benefit of UFS, only 1‐in‐5 UFS patients actually realize maximal survival when known factors highly associated with outcomes are assessed. Patients are proportionally more likely to do worst, rather than best after UFS treatment. Similarly staged patients undergoing ITT‐neoadjuvant therapy achieve survival superior to the majority of UFS patients. Patients and providers should be aware of the false perception of ‘optimal’ survival benefit with UFS in anatomically resectable PDAC.
Diamidophosphate (DAP): A Plausible Prebiotic Phosphorylating Reagent with a Chem to BioChem Potential?
Authors: Osumah Abdulakeem , Krishnamurthy Ramanarayanan 
Published: July 2021

AbstractKnown since the 1890s, diamidophosphate (DAP) has been investigated within the context of its inorganic chemistry. In 1999 – with the demonstration of DAP's potential as a phosphorylating agent of sugars in aqueous medium – began the exciting phase of research about DAP's role as a plausible prebiotic phosphorylating agent. More recently, in the last five years, there has been a steady increase in the publications that have documented the surprising versatility of DAP enabling the emergence of many classes of biomolecules of life, such as nucleic acids, peptides and protocells. Thus, though in its infancy, DAP seems to be uniquely positioned to play a central role in modelling abiotic‐ to prebiotic‐chemical evolution. In this context, there is a need for systematic investigations for: (a) establishing DAP's likely availability on the early Earth, and (b) developing DAP's potential as a tool for use in synthetic and bioorganic chemistry.
High‐Throughput Solid‐Phase Assay for Substrate Profiling and Directed Evolution of Transketolase
Authors: Ocal Nazim , Lagarde Aurélie , L'enfant Mélanie , Charmantray Franck , Hecquet Laurence 
Published: July 2021

AbstractThiamine diphosphate‐dependent enzymes, and specifically transketolases, form one of the most important families of biocatalytic tools for enantioselective carbon‐carbon bond formation yielding various hydroxyketones of biological interest. To enable substrate profiling of transketolases for acceptance of different donors and acceptors, a simple, direct colorimetric assay based on pH reaction variation was developed to establish a high‐throughput solid‐phase assay. This assay reduces the screening effort in the directed evolution of transketolases, as only active variants are selected for further analysis. Transketolase activity is detected as bicarbonate anions released from the α‐ketoacid donor substrate, which causes the pH to rise. A pH indicator, bromothymol blue, which changes color from yellow to blue in alkaline conditions, was used to directly detect, with the naked eye, clones expressing active transketolase variants, obviating enzyme extraction.
Antitumor effects of 3‐bromoascochlorin on small cell lung cancer via inhibiting MAPK pathway
Authors: Zhang Zhenhua , Zhang Yidi , Yang Chunju , Wang Qianyu , Wang Hong , Zhang Yanting , Deng Wenbin , Nie Yichu , Liu Yonghong , Luo Xiaowei , Huang Jie , Wang Junjian 
Published: July 2021

AbstractSmall cell lung cancer (SCLC) was defined as a recalcitrant cancer, and novel therapies are urgently needed. Marine natural products (MNPs) may bring continuing hope for treatment of SCLC. In this study, 3‐bromoascochlorin (BAS), an MNP isolated from the coral‐derived fungus Acremonium sclerotigenum GXIMD 02501, was primarily screened out with antiproliferative activity towards SCLC cell lines. Then western blot analysis (WB) and flow cytometry were conducted, and we found BAS could induce the apoptosis of H446 and H69AR cells. Besides, BAS could suppress the invasion and migration of H446. In an SCLC xenograft mice model, BAS inhibited the growth of tumor without affecting the body weight of mice. Finally, the underlying mechanisms were preliminarily explored. According to the results of RNA‐seq, reverse transcription‐quantitative polymerase chain reaction, and WB, our results revealed that BAS exerted antitumor activity via inhibiting mitogen‐activated protein kinase (MAPK)/extracellular signal‐regulated kinases (ERK) pathway. Collectively, these results indicated that BAS can be used as a promising compound for the treatment of human SCLC.
Acute generalized exanthematous pustulosis in a postpartum woman
Authors: Toyoshima Hirokazu , Mizuno Midori , Tanigawa Motoaki , Tanaka Hiroyuki , Nakanishi Yuki , Sakabe Shigetoshi 
Published: July 2021

AbstractThe distribution of pustular erythema, characteristic clinical course, and pathological findings can help diagnose acute generalized exanthematous pustulosis. Clinical management should include discontinuation of the suspected drug, hydrocortisone administration, and careful follow‐up examination.
Nightmare after iliac vein stenting: Spinal epidural hematoma
Authors: Jenab Yaser , Barbati Mohammad E. , Ajam Ali , Tofighi Saeed , Hosseini Kaveh , Jalaie Houman 
Published: July 2021

AbstractSpinal epidural hematoma is a rare but devastating complication of iliac vein stenting. Radicular back pain during and after procedure is an alarming sign for this complication.
Lymphangioma of the fetal neck within the PIK3CA‐related‐overgrowth spectrum (PROS): A case report
Authors: Scharf Jann Lennard , Gembicki Michael , Dracopoulos Christoph , Hellenbroich Yorck , Offermann Anne , Stichtenoth Guido , Tafazzoli‐Lari Kianusch , Tharun Lars , Weichert Jan 
Published: July 2021

AbstractThe delineation of the prenatal diagnostic key features of PIK3CA‐related overgrowth spectrum disorders will assume a crucial part in future and a prenatal diagnosis of the causing mutations would provide physicians with a simplified interdisciplinary perinatal management.
Pilomyxoid astrocytoma of the thoracic spinal cord: Extremely rare case report of over 70‐year‐old patient
Authors: Almzeogi Mohamed A. , Abousabie Zeyad A. , Kostic Jelena , Janicijevic Aleksandar M. , Tasic Goran 
Published: July 2021

AbstractThe Pilomyxoid is rare tumor in elderly population, in addition to the occurrence of an isolated lesion in spinal cord is extremely rare in non‐pediatric population. Taking biopsy and subtotal resection is the starting point in essential approach for the treatment. After defining the histopathological nature of the tumor and specified that is Pilomyxoid, the next step is the combination of reoperation and adjuvant therapy.
Factors Influencing the Electrocatalytic Properties of Graphene Oxide – Gold Nanoparticles Hybrid System
Authors: Klekotka Ewelina , Kasztelan Mateusz , Palys Barbara 
Published: July 2021

AbstractGraphene oxide (GO) – gold nanoparticles (AuNPs) nanocomposites are promising materials for H2O2 electrochemical sensors. Surface composition of GO is an important factor influencing the sensitivity. In this study GO has been mildly reduced by ammonia (GO‐NH3) or sodium hydroxide solution (GO‐NaOH). Such mild reduction opens up the epoxide groups on the GO surface but not the other oxygen functionalities. The electrochemical reduction of GO has been carried out too. It is found that the structure of the electrochemically reduced graphene oxide (ERGO) depends on the concentration of GO used to prepare the layer. For concentrated GO (10 mg/ml) the electro‐reduction leaves OH surface groups while for lower concentrations all surface groups can be removed. All GO materials listed above were combined with AuNPs and examined as possible amperometric H2O2 sensors. The two types of layers were examined: AuNPs deposited on the top of the GO material or AuNPs deposited under the GO material layer. Among studied composites ERGO obtained from 5 mg/ml GO on the AuNPs layer showed the highest sensitivity (155.6 μA cm−2 mM−1 at −0.4 V vs Ag/AgCl).
Multi‐Enzyme‐Modified Bioanode Utilising Starch as a Fuel
Authors: Toda Rurika , Tatara Ryoichi , Horiba Tatsuo , Komaba Shinichi 
Published: July 2021

AbstractA new multi‐enzyme bioanode utilising starch, maltose, and glucose as fuels is demonstrated. The unique combination of α‐amylase, glucoamylase, mutarotase, and flavin‐adenine dinucleotide‐dependent glucose dehydrogenase enables the bioanode to utilise a polysaccharide, starch, as a fuel. Replacing α‐amylase and glucoamylase with β‐amylase and maltase does not lead to effective starch degradation, possibly because of termination of the cleaving reaction by β‐AMY at the branching point of the starch molecules. Furthermore, by using a reduced graphene oxide/multi‐walled carbon nanotubes composite as the carbon support for enzyme immobilisation, the new bioanode demonstrates a high oxidation current density of 5.8 mA cm−2 in neutral phosphate‐buffered solution containing 0.8 % (w/v) starch. Finally, a bioanode containing the six enzymes, α‐amylase, β‐amylase, glucoamylase, maltase, mutarotase, and flavin adenine dependent glucose dehydrogenase, is fabricated. The fabricated bioanode is effective in degrading glucose, maltose, and starch. Thus, this study provides an important fundamental strategy for controlling the applicability of bioanodes by adjusting the loaded enzymes.
Crystallographic phase formation of iron oxide particles produced from iron nitrate by liquid flame spray with a dual oxygen flow
Authors: Sorvali Miika , Honkanen Mari , Hyvärinen Leo , Kuisma Ritva , Larjo Jussi , Mäkelä Jyrki M. 
Published: July 2021

AbstractWe fabricated iron oxide particles from iron(III) nitrate in a liquid flame spray synthesis. Unlike in most liquid flame spray studies, we implemented a secondary oxygen flow. The effect of the gas flow setup and two additives to the precursor solution, oxalic acid and citric acid, on the resulting particles was studied, with the focus on crystallographic phase composition. The synthesis yielded either pure maghemite or maghemite/hematite mixed phase powders. For solutions without additives, the maghemite fraction was almost linearly dependent on the equivalence ratio. The specific surface area was highest for the smallest equivalence ratios, then decreased, and increased again for the highest values. Some variation was observed between samples with equal equivalence ratios but the total oxygen flow divided differently between the two oxygen channels, a higher atomization flow promoting larger hematite fraction, and higher specific surface area. Both additives reduced the amount of hematite in the powder samples, citric acid being the more efficient one. Citric acid slightly raised the specific surface area, whereas oxalic acid dropped it in half.