bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthopaedic Surgery Residency Program Social Media Presence During the COVID-19 Pandemic
Authors: Bram Joshua T. , Jia Lori , Huffman William , Ahn Jaimo 
Published: October 2021

Background:
In light of away rotation and in-person interview cancellations for the 2020 to 2021 application cycle, social media has become a popular tool for orthopaedic surgery residency programs to highlight their strengths, curricula, and social life to prospective applicants. The authors sought to explore the proliferation and utilization of 3 popular social media platforms by both orthopaedic surgery departments and residencies.

Methods:
Orthopaedic surgery departmental and residency program social media accounts and their creation dates across Facebook, Twitter, and Instagram were identified using a standardized search methodology. Residency Instagram accounts were further evaluated for the number of posts, followers, likes, and comments. Both departments and residency programs were cohorted by affiliation with a US News &World Report (USNWR) top 50 American hospital for orthopaedics or by status as a Doximity top 20 program based on reputation.

Results:
Across a total of 192 residency programs included for analysis, Instagram was the most popular social media platform (61.5%), followed by Twitter (19.8%) and Facebook (10.4%). Conversely, orthopaedic departments more frequently used Facebook (33.9%) and Twitter (28.1%) over Instagram (17.2%). Of the 118 residency Instagram accounts, 102 (86.4%) were created after the onset of the COVID-19 pandemic. Larger residency programs (≥6 spots/year) and those programs in the Doximity top 20 or affiliated with USNWR top 50 orthopaedic hospitals had a greater number of followers as well as likes and comments per post (p < 0.05 for all).

Conclusions:
Given the recruitment challenges faced by residency programs because of the COVID-19 pandemic, Instagram has rapidly become a prominent platform for attracting orthopaedic surgery applicants. These accounts have a large number of followers, particularly for residency programs with higher Doximity reputation rankings.
U-Pb Geochronology and Hf Isotope Geochemistry of the Turtleback Complex and East Sound Group, San Juan Islands, Northwestern North American Cordillera
Authors: Plange Kojo M. , Gehrels George E. , Brown Edwin H. , Schermer Elizabeth R. , McClelland William C. 
Published: October 2021

Abstract
This study focuses on Paleozoic rocks of the Turtleback Complex (TBC) and East Sound Group (ESG) of northwestern Washington. These assemblages record a long and complex history of magmatism, sedimentation, and volcanism as part of the Chilliwack composite terrane. This study investigates the tectonic setting and magmatic evolution of the Chilliwack terrane by analyzing U-Pb geochronologic and Hf isotopic data from zircons extracted from igneous and sedimentary rocks of the TBC and ESG. Igneous rocks of the TBC yield U-Pb ages of ~420-~370 Ma for zircon rims, which are interpreted to record pluton crystallization, and ages of ~500-370 Ma for inherited cores and antecrysts. Zircons older than 410-400 Ma yield typical igneous values of U/Th and U concentration and somewhat more evolved εHft values (+5 to +10), whereas younger grains yield values of U/Th and U concentrations that record ongoing metamorphism and have more juvenile εHft values of +10 to +15. This evolution is interpreted to have occurred in a long-lived island arc that experienced a transition at ~410-400 Ma from crustal thickening to regional crustal extension. Detrital zircon grains from the ESG yield dominant ages of ~421-~366 Ma and εHft values of +8 to +15, both of which overlap with values from igneous rocks of the underlying TBC. Strata of the ESG also contain abundant older zircon grains, with a dominant age peak of ~1860 Ma and subordinate peaks at 2673, 2570, 1485, 1113, 736, and 553 Ma. When compared with similar results from other assemblages and terranes in the northern Cordillera, our results suggest possible connections with the Yellow Aster Complex of the nearby North Cascade Range. Our results also suggest general similarities with the Alexander terrane, Wrangellia terrane, and southeast Alaska portion of the Yukon-Tanana terrane. These similarities are consistent with previous interpretations that the Chilliwack composite terrane formed in association with the Alexander, Wrangellia, and southeast Alaska portion of the Yukon-Tanana terrane along the paleo-Arctic margin of Laurentia during early Paleozoic time. Our work also illustrates the importance of recycling of older magmatic rocks over millions of years within a juvenile island arc system.
Memes e imaginarios sociales mexicanos en Copa del Mundial de la FIFA 2018
Authors: Bañuelos Capistrán Jacob , Pérez Restovic Branko 
Published: October 2021

Los memes se han convertido en una forma de expresión representativa de la cultura mediática digital, empleada para la representación de valores e imaginarios sociales. Como caso de estudio realizamos el análisis de los memes publicados en el marco de la actuación de la selección mexicana de fútbol en la Copa Mundial de FIFA-Rusia 2018, lo que permitió comprender los imaginarios sociales que construyen la identidad cultural mexicana en redes como Facebook, Instagram, Twitter y plataformas digitales como WhatsApp y Sitios Web Informativos. El estudio aplica una metodología etnográfica digital cualitativa, con enfoque sociocultural, para fenómenos en redes y plataformas digitales (Hine, 2005; Wouters y Beaulieu, 2009; Ardèvol y Gómez, 2012), lo permitió recuperar 600 memes en diversas comunidades, plataformas y redes sociales cercanas. Para su categorización y análisis empleamos los conceptos sobre imaginarios sociales de Cornelius Castoriadis (1997), identidad mexicana desde Ramos (1951), Paz (1992), Villoro (2018), Giddens (1997), Giménez (2000), Berger y Luckmann (2006), así como el abordaje de conceptos propios de las narrativas digitales como el mismo meme en Dawkins (1989), transmedia y multiplataforma, desde Jenkins (2008) y Scolari (2013). El estudio revela que los memes publicados en el contexto de este evento deportivo, a través de plataformas digitales y redes sociales, representan imaginarios sociales instituidos con valores que han prevalecido y se actualizan en la definición de la identidad cultural mexicana.
A Collocated Finite Volume Scheme for High-Performance Simulation of Induced Seismicity in Geo-Energy Applications
Authors: Novikov A. , Voskov D. V. , Khait M. , Hajibeygi H. , Jansen J. D. 
Published: October 2021

Abstract
We develop a collocated Finite Volume Method (FVM) to study induced seismicity as a result of pore pressure fluctuations. A discrete system is obtained based on a fully-implicit coupled description of flow, elastic deformation, and contact mechanics at fault surfaces on a fully unstructured mesh. The cell-centered collocated scheme leads to convenient integration of the different physical equations, as the unknowns share the same discrete locations on the mesh. Additionally, a multi-point flux approximation is formulated in a general procedure to treat heterogeneity, anisotropy, and cross-derivative terms for both flow and mechanics equations. The resulting system, though flexible and accurate, can lead to excessive computational costs for field-relevant applications. To resolve this limitation, a scalable parallel solution algorithm is developed and presented. Several proof-of-concept numerical tests, including benchmark studies with analytical solutions, are investigated. It is found that the presented method is indeed accurate, stable and efficient; and as such promising for accurate and efficient simulation of induced seismicity.
Theoretical and Numerical Investigation of Supersonic Multiphase Gas Injection
Authors: Zhu Da , Sivagnanam Mohan , Gates Ian 
Published: October 2021

Abstract
Supersonic gas injection can help deliver gas uniformly to a reservoir, regardless of reservoir conditions. This technology has played a key role in enhanced oil recovery (EOR) and in particular, thermal enhanced oil recovery operations. Most previous studies have focused on single phase gas injection whereas in most field applications, multiphase and multicomponent situations occur.
In the research documented in this paper, we report on results of evaluations of compressible multiphase supersonic gas flows in which gas is the continuous phase is seeded with dispersed liquid droplets or solid particles. Theoretical derivation and numerical simulations with and without relative motions between continuous and disperse phases are examined first. The results illustrate that the shock wave structures and flow properties associated with the multiphase gas flows are different than that of single-phase isentropic flows. The existence and importance of relaxation zones after the normal shock wave in multiphase flow is described. Numerical computational fluid dynamics (CFD) simulations are conducted to show how the multiphase multicomponent flow affects gas phase injection under different conditions. The impact of solid/liquid mass loading on flow performance is discussed. Finally, the practical application of the findings is discussed.
TAS-Seq: A Robust and Sensitive Amplification Method for Beads-based ScRNA-seq
Authors: Shichino Shigeyuki , Ueha Satoshi , Hashimoto Shinichi , Ogawa Tatsuro , Aoki Hiroyasu , Wu Bin , Chen Chang-Yu , Kitabatake Masahiro , Ouji-Sageshima Noriko , Sawabata Noriyoshi , Kawaguchi Takeshi , Okayama Toshitugu , Sugihara Eiji , Hontsu Shigeto , Ito Toshihiro , Ikeo Kazuho , Sato Taka-aki , Matushima Kouji 
Published: October 2021

Abstract
Single-cell RNA-sequencing (scRNA-seq) is valuable for analyzing cellular heterogeneity. Cell composition accuracy is critical for analyzing cell–cell interaction networks from scRNA-seq data. We developed terminator-assisted solid-phase cDNA amplification and sequencing (TAS-Seq) for scRNA-seq based on a terminator, terminal transferase, and nanowell/bead-based scRNA-seq platform; TAS-Seq showed high tolerance to variations in the terminal transferase reaction, which complicate the handling of existing terminal transferase-based scRNA-seq methods. In murine and human lung samples, TAS-Seq yielded scRNA-seq data that were highly correlated with flow-cytometric data, showing higher gene-detection sensitivity and more robust detection of important cell–cell interactions and specific cell subsets that significantly contribute to specific gene expression than widely-used methods.
Investigating polystyrene nanoplastics-induced reproductive toxicity in vitro: Focus on Nrf2-PKM2-autophagy signaling pathway
Authors: Li Siwen , Ma Yu , Ye Shuzi , Su Ying , Hu Die , Xiao Fang 
Published: October 2021

Abstract
As an issue of widespread concern, microplastics pollution has emerged as a harmful environmental pollutant. Nanoplastics (NaPs) has reported to accumulate in the testes and cause degeneration in the seminiferous tubules. However, the current research involving NaPs-induced reproductive toxicity remains poorly understood. The current work aimed to investigate the mechanisms of NaPs-induced reproductive injury in vitro. At first, we found that 80 nm fluorescent NaPs could enter into GC-2spd(ts) cells by fluorescent inverted microscope. Our results also demonstrated that suppression of reactive oxygen species (ROS) inhibited NaPs-triggered mitochondrial apoptosis and autophagy in GC-2spd(ts) cells. We also found that NaPs treatment did not change the interaction between nuclear factor erythroid-derived 2-related factor (Nrf2) and Kelch-like ECH associated protein 1 (Keap1), while inhibiting nuclear accumulation of Nrf2 protein. Further in vitro experiments showed that NaPs-induced reproductive toxicity associated with reducing dimerize pyruvate kinase M2 (PKM2), which are ascribed to the loss of Nrf2. Meanwhile, improving nuclear accumulation of Nrf2 might interact with PKM2 to rescue mitochondrial apoptosis caused by NaPs. Together, this study highlight that disturbing Nrf2-PKM2 signaling is essential process of NaPs-induced reproductive toxicity and provide valuable insights into the mechanism of microplastics-induced reproductive toxicity.
Molecular Epidemiology of Community-Onset Clostridioides Difficile Infections At A Tertiary Hospital In Mainland China: A Ten-Year (2010-2019) Retrospective Study
Authors: Chen Yunbo , Bu Lihong , Lv Tao , Zheng Lisi , Gu Silan , He Jianqin 
Published: October 2021

Abstract
Background: Clostridioides difficile infection (CDI) is an increasingly common disease in healthcare facilities and community settings. However, there are limited reports of community-onset CDI (CO-CDI) in China. We retrospectively analyzed the molecular epidemiology of CO-CDI at a tertiary hospital over a period of 10 years. A total of 1307 stool samples from 1213 outpatients were tested by culturing. The presence of toxin genes (tcdA, tcdB, cdtA, and cdtB) were confirmed by PCR. Toxigenic strains were typed using multilocus sequence typing (MLST). Susceptibility to 9 antimicrobials was evaluated using the E-test.Results: Eighty-nine of 1213 outpatients (7.3%) had CO-CDI, 4 of these patients (4.5%) had one or more recurrence, and there were 95 strains of toxigenic C. difficile. Among these strains, 82 (86.3%) had the tcdA and tcdB genes (A+B+) and 5 of these 82 strains were positive for the binary toxin genes (cdtA and cdtB); the other 13 strains (13.7%) had the tcdB gene only (A−B+). There were 15 different STs, and the most prevalent were ST-54 (23.2%), ST-35 (16.8%), and ST-2 (13.7%). All strains were susceptible to metronidazole and vancomycin, and had low resistance to moxifloxacin and tetracycline, but had high resistance to ciprofloxacin, clindamycin, and erythromycin. Twenty-three isolates (24.2%) were multidrug-resistant.Conclusions: Outpatients with CDI were common during this period in our hospital. The C. difficile isolates had high genetic diversity. All isolates were susceptible to metronidazole and vancomycin, and nearly one quarter of all isolates had multidrug resistance.
Qualitative analysis of the response regimes and triggering mechanism of bistable NES
Authors: WU Zhenhang , Seguy Sébastien , Paredes Manuel 
Published: October 2021

Abstract
The main focus of this study is the development of an adapted complex variable method in the vicinity of equilibrium in bistable NES. A simplified chaos trigger model is established to describe the distance between the stable phase cycle and the pseudo-separatrix. An analytical expression can predict the excitation threshold for chaos occurrence. The relative positions between the chaos trigger threshold line and the Slow Invariant Manifold (SIM) structure can express the distribution of response regimes under growing harmonic excitation. This topological structure implies the alternation of the response regime and helps to classify the bistable NES. The experiment compares the analytical result of intra-well oscillation with the numerical result in the frequency domain. The experimental response regimes under different input energy levels and frequency domains have been observed and give ideas to guide the optimal design of a bistable NES. It is shown that the modest bistable NES possesses strong robustness to frequency perturbation.
Assessment of Groundwater Vulnerability and Pollution Risk using AVI Model, PSI and RGPI Indexes: Applied to Southern Gabes Aquifer System, Tunisia
Authors: Atoui Mounir , Agoubi Belgacem 
Published: October 2021

Abstract
Southern Gabes aquifer is part of coastal Jeffara plain located in southeastern Tunisia. It consists a semi-arid area in which groundwater is the main source to water supply for several socio-economic sectors. Southern Gabes aquifer suffers from excessive abstraction and heavy anthropogenic pressures that make local groundwater resources threatened by pollution risks. This study aims to assess groundwater vulnerability, evaluate and delineate groundwater risk regions. For this a 17 water samples were carried out in the study area and chemical composition were analyzed. A well-known AVI model has been used to assess aquifer vulnerability and new algorithms of sensitivity to pollution index (PSI) and risk groundwater to pollution index (RGPI) were implemented and used to assess, classify and mapping groundwater pollution risk. The method used in this study seems giving more precise results compared to conventional approaches. Moreover, this method allows assessing the pollution risk with flexible and reliable algorithm even with limited dataset. Results reveal that study area suffers from high risk. 41% of total surface of study area has a very high risk. Nonetheless only 30% of study area has a low to insignificant risk to pollution which necessitates taking severe precautions to protect the southern Gabes aquifer system. Hence, the poor natural protective capacity of study area needs a rapid intervention by local authorities in order to develop proactive solutions to protect and preserve groundwater resources from pollution risks and establish a long-term program for groundwater resources sustainable development.
Conceptualization of Pollution of Groundwater Resources in Ilaje Area, Nigeria, West Africa: Contribution From Hydrogeochemical and Numerical Index Techniques
Authors: Erukubami Omowumi Funmilola , Adelakun Adeboye Tolu , Asiwaju-Bello Yinusa Ayodele , Olabode Oluwaseun Franklin 
Published: October 2021

Abstract
Ilaje is a coastal settlement in Nigeria with a large number of its population depending on groundwater, through hand-dug wells, for domestic and irrigation use. Due to the vulnerability of coastal aquifers to contamination, for this study, 29 groundwater samples were analyzed for physicochemical parameters, major ions and trace elements to appraise the quality, pollution status and health risks of Ilaje water sources. Hydrogeochemical analysis revealed cationic, anionic and trace metals concentrations in these orders: Na+>K+>Mg2+>Ca2+, HCO3->Cl->SO42->NO3-, and Fe2+> Co2+>Pb2+> Ni2+> Mn2+ respectively and prevalence of Na-Cl facies suggesting imprints of saline-water intrusion. The results from the pollution evaluation and irrigation index methods revealed that the groundwater has significant trace metal pollution and has low to no suitability for irrigation. Furthermore, in this study, the carcinogenic and non-carcinogenic health risks posed by ingestion of the water to adults and children were determined using Probability of Cancer Risk, Chronic Daily Intake, Health hazard Quotient and Indices. It was discovered that upon exposure to the water for a long period of time, residents are prone to illnesses such as kidney disfunction, brain damage, diabetes and cancer. The pollution of the shallow groundwater resources hinges on the highly porous and permeable nature of the alluvial aquifer system of the area. This work recommends solutions like proper monitoring system and treatment plants installation to control the problem of groundwater pollution in the area.
Lessons Learned: Developing a Better Treatment for Patients With Chronic Pain and Opioid User Disorder
Authors: Wachholtz Amy , Robinson Dallas , Epstein Elizabeth 
Published: October 2021

Abstract
Introduction: It is critical to develop empirically based, community-treatment friendly, psychotherapy interventions to improve treatment for patients with comorbid chronic pain and Opioid Use Disorder (OUD). Understanding factors that increase patient adherence and attendance is important, along with strategies targeted to address those issues.Methods: Based on initial psychophysiology research on adults with OUD and chronic pain, we created an integrated cognitive-behavioral, 12-week outpatient group therapy called STOP (Self-regulation Therapy for Opioid addiction and Pain). In this study, we pilot tested STOP in a Stage 1a feasibility and acceptability study to identify unique treatment needs and factors that increased session attendance, adherence to treatment, and improved outcomes. Fourteen individuals on medication for OUD with co-occurring chronic pain participated.Results: STOP had high attendance rates (80%; and active patient engagement). Urine toxicology showed no illicit drug use after week 8. Data analysis from pre-intervention to a 3-month follow-up showed significant functional improvement (F(1,12)=45.82;p<0.001) and decreased pain severity levels (F(1,12)=37.62;p<0.01). Participants reported appreciation of the unique tools to counteract physiological activation during a pain flare or craving. Participants also reported benefit from in-session visual aids, applicable pain psychology information, take-home worksheets, tools for relaxation practice, learning to apply the therapy tools. Discussion: STOP is a 90-minute 12-week rolling-entry group therapy based on previous research identifying psychophysiological needs of pain and OUD patients that can be integrated into community addiction treatment clinics. Conclusion: Preliminary results of STOP are promising with high patient engagement and adherence and significant reductions in drug use and pain. Trial registration: ClinicalTrials.Gov NCT03363243, Registered Dec 6, 2017, https://clinicaltrials.gov/ct2/show/NCT03363243
Long-term Performance of Nanoparticle Incorporated Eco-friendly Concrete in Natural Seawater Environment
Authors: Philip John , Harilal Manu , Balakrishnan Anandkumar , George Rani Pongachira , Albert Shaju Kattukaran 
Published: October 2021

Abstract
The use of blended concrete has widely gained industrial importance owing to the CO2 gas emissions and carbon footprint resulting from the production of ordinary Portland cement (OPC). Despite the advancements, the deterioration of concrete structures raises a significant threat to their long term durability and service life in aggressive conditions. In this work, the long-term antifouling, strength and durability properties of a blended eco-friendly concrete with OPC, fly ash, nanoparticles, and corrosion inhibitor is evaluated in natural seawater for one year. The biofouling attachment, total viability count (TVC), mechanical strength, alkalinity and free chloride contents were measured and the results were compared with OPC concrete. A four-order reduction in the total biomass and total bacterial density is observed on the surface of the blended concrete. Further, a significantly lower chloride and water penetration depth, free chloride content, compact and smooth surface morphology devoid of cracks and high C-S-H content are observed in blended concrete, compared to the OPC concrete, after exposure in seawater for one year. From the results, it is seen that the blended concrete mix is promising for applications in seawater environments because of its superior biofouling resistance, mechanical properties and durability.