bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Patient-Reported Dysphagia and Reflux Symptoms in Obstructive Sleep Apnea
Authors: Bhutada Ankita M. , Broughton William A. , Beverly Brenda L. , Choi Dahye , Barui Sandip , (Focht) Garand Kendrea L. 
Published: December 2021

Purpose:
Despite the reported high prevalence of dysphagia and reflux, patients with obstructive sleep apnea (OSA) are not routinely screened for dysphagia or reflux during conventional OSA management. The purpose of this exploratory study was to (a) identify prevalences of dysphagia and reflux self-reported symptoms in patients with OSA and (b) determine associations between dysphagia and reflux symptoms and demographic and clinical variables.

Method:
A chart review was completed on 75 patients with treated OSA during routine medical management at a university-affiliated sleep center. All participants completed the 10-Item Eating Assessment Tool (EAT-10) and Reflux Symptom Index (RSI) questionnaires, which are patient-reported outcome measures (PROMs) of swallowing and reflux symptoms, respectively. Relevant demographic and clinical variables were extracted. A binary logistic regression was computed to examine the relationships between dysphagia and reflux PROMs and demographic and clinical variables.

Result:

Sixty-three participants met eligibility criteria (
M
age
= 64 years). In addition, 14% (
n
= 9) and 11% (
n
= 7) of patients with OSA syndrome reported swallowing and reflux symptoms, respectively. Among the demographic and clinical variables investigated, there were no significant predictive factors for EAT-10 scores. Age and apnea–hypopnea index were significant predictive factors for RSI scores.

Conclusions:
To our knowledge, this is the first preliminary study to investigate swallowing and reflux symptoms concurrently in OSA, as well as potential mitigating factors. Although our findings suggest a relatively low percentage of patients with OSA report dysphagia and reflux symptoms, the true prevalences of swallowing and reflux disorders may be higher based on previous evidence suggesting that pharyngeal afferent (sensory) dysfunction may cause patients to underestimate their symptoms.
A framework for statistical design of a brushless DC motor considering efficiency maximisation
Authors: Sadrossadat Sayed Alireza , Rahmani Omid 
Published: December 2021

AbstractIn this study, a framework for statistical design of a brushless DC (BLDC) motor is proposed in order to maximise yield while keeping efficiency as high as possible and the non‐linear constraints, that is, limitations of flux density, current density and physical dimensions, satisfied. The proposed yield maximisation method has two major steps: polyhedral approximation of the constraint region and yield maximisation. By implementing the proposed method, the optimum design parameters, that is, embrace, thickness and length of magnet, are obtained with maximum immunity to variations in magnet dimensions. Also, highly accurate artificial neural network‐based models are used to estimate the objective function and constraints. It is also shown that by adjusting performance constraints (efficiency and flux density), different design goals can be achieved which help to choose the appropriate design according to the designer's goals.
Liquid Argon Instrumentation and Monitoring in LEGEND-200
Authors: Schwarz Mario , Krause Patrick , Leonhardt Andreas , Papp Laszlo , Schönert Stefan , Wiesinger Christoph , Fomina Maria , Gusev Konstantin , Rumyantseva Nadezda , Shevchik Egor , Zinatulina Daniya , Araujo Gabriela R. 
Published: December 2021

LEGEND is the next-generation experiment searching for the neutrinoless double beta decay in 76Ge. The first stage, LEGEND-200, takes over the cryogenic infrastructure of GERDA at LNGS: an instrumented water tank surrounding a 64 m3 liquid argon cryostat. Around 200 kg of Ge detectors will be deployed in the cryostat, with the liquid argon acting as cooling medium, high-purity passive shielding and secondary detection medium. For the latter purpose, a liquid argon instrumentation is developed, based on the system used in GERDA Phase II. Wavelength shifting fibers coated with TPB are arranged in two concentric barrels. Both ends are read out by SiPM arrays. A wavelength shifting reflector surrounds the array in order to enhance the light collection far from the array. The LLAMA is installed in the cryostat to permanently monitor the optical parameters and to provide in-situ inputs for modeling purposes.
The design of all parts of the LEGEND-200 LAr instrumentation is presented. An overview of the geometry, operation principle, and off-line data analysis of the LLAMA is shown.
Arthroscopic Lunotriquetral Ligamentoplasty, from the Cadaver Lab to the Clinical Practice
Authors: Cruz-Sánchez Marcos , Martínez-Andrade Cristóbal 
Published: December 2021

Abstract
Introduction There has been an increase in the diagnosis of injuries to the intrinsic ligaments of the wrist due to the more widespread use of arthroscopy in the treatment of patients with musculoskeletal wrist pain, and arthroscopy is particularly very helpful to determine the etiology of these lesions at the ulnar level. The treatment of lunotriquetral ligament injuries encompasses different techniques with results that are little reproducible. Ligament reconstruction through tendon grafting has shown favorable results, but it involves extensive open approaches that lead to a slower recovery a lower range of joint motion due to the excess of scar tissue. The objective of the present study is to describe the performance, in a cadaver, of a minimally-invasive lunotriquetral and secondary-stabilizer ligamentoplasty and its application in a representative clinical case.
Material and Methods A preliminary study of six specimens in which a lunotriquetral and secondary-stabilizer ligamentoplasty was performed consecutively through a free tendon graft with arthroscopic assistance. We proceeded to recreate the complete ligament injury, and to perform an assessment of lunotriquetral instability according to the Geissler classification and an arthroscopic ballottement test. We describe the surgical technique, ligament stability after the ligamentoplasty, and the subsequent anatomical dissection, assessing the anatomical structures susceptible to iatrogenic injury. We also describe the application of the technique in one case, comparing the clinical parameters before and after the procedure: range of motion of the joint, strength, pain and the shortened version of the Disabilities of the Arm, Hand, and Shoulder (QuickDASH) questionnaire.
Results The ligamentoplasties performed showed recovery of the stability of the lunotriquetral interval assessed according to the Geissler classification and the arthroscopic ballottement test. In the dissection of the specimens, no iatrogenic lesions were found in the tendons or the surfaces of the mediocarpal and radiocarpal joints. The average distances between the nearest bone tunnels and nerves were of 7.3 mm for the sensory branch of the ulnar nerve, of 3.6 mm for the posterior interosseous nerve, and of 4.5 mm for the ulnar neurovascular bundle. No fractures were observed in the tunnelled bones. In the clinical case herein presented, six months after the intervention, there was an improvement in strength and preoperative pain, with a slight decrease in the joint range of motion (15% compared to the contralateral joint).
Conclusions The lunotriquetral ligamentoplasty herein described could contribute to the biomechanical restoration of the carpus and be an option for recosntruction in selected cases. Its performance through minimally-invasive techniques, and the use of a free tendon graft together with specific rehabilitation should be considered to optimize the outcomes.
Percutaneous Dorsal Approach for Fractures of the Hook of the Hamate: A Less Common but Effective Option
Authors: Gómez Borja Occhi , Olea Ángel García , Sierra Virginia Herrero 
Published: December 2021

Abstract
Introduction Hook of hamate fractures are rare. The best treatment option is a source of debate; it ranges from conservative to surgical techniques, including resection of the hook or a volar approach followed by internal fixation. These techniques are not exempt from risk. Minimal invasive fixation using a dorsal percutaneous approach and a headless, cannulated mini screw is another option, although not commonly considered. We present a case series of patients who underwent this surgical technique.
Methods This is a retrospective review of four patients with nondisplaced hook of hamate fractures treated with dorsal percutaneous fixation. The evaluation included symptoms, physical examination, and radiological (radiographs, magnetic resonance imaging [MRI], and computed tomography [CT]) findings, as well as pre and postoperative strength (determined with a Jamar (JLW Instruments, Chicago, USA) hydraulic dynamometer) and quick disabilities of the arm, shoulder and hand (QuickDASH) scores.
Results The union rate was 100% with no associated complications. All patients resumed their preinjury activities 3 months after the surgery and reported they would undergo surgery again if needed.
Conclusion This retrospective study shows that safe treatment of nondisplaced hook of hamate fractures with percutaneous dorsal fixation is feasible, with excellent clinical outcomes. In any case, our sample is limited, and further studies are required.
An open repository of real-time COVID-19 indicators
Authors: Reinhart Alex , Brooks Logan , Jahja Maria , Rumack Aaron , Tang Jingjing , Agrawal Sumit , Al Saeed Wael , Arnold Taylor , Basu Amartya , Bien Jacob , Cabrera Ángel A. , Chin Andrew , Chua Eu Jing , Clark Brian , Colquhoun Sarah , DeFries Nat , Farrow David C. , Forlizzi Jodi , Grabman Jed , Gratzl Samuel , Green Alden , Haff George , Han Robin , Harwood Kate , Hu Addison J. , Hyde Raphael , Hyun Sangwon , Joshi Ananya , Kim Jimi , Kuznetsov Andrew , La Motte-Kerr Wichada , Lee Yeon Jin , Lee Kenneth , Lipton Zachary C. , Liu Michael X. , Mackey Lester , Mazaitis Kathryn , McDonald Daniel J. , McGuinness Phillip , Narasimhan Balasubramanian , O’Brien Michael P. , Oliveira Natalia L. , Patil Pratik , Perer Adam , Politsch Collin A. , Rajanala Samyak , Rucker Dawn , Scott Chris , Shah Nigam H. , Shankar Vishnu , Sharpnack James , Shemetov Dmitry , Simon Noah , Smith Benjamin Y. , Srivastava Vishakha , Tan Shuyi , Tibshirani Robert , Tuzhilina Elena , Van Nortwick Ana Karina , Ventura Valérie , Wasserman Larry , Weaver Benjamin , Weiss Jeremy C. , Whitman Spencer , Williams Kristin , Rosenfeld Roni , Tibshirani Ryan J. 
Published: December 2021

Significance
To study the COVID-19 pandemic, its effects on society, and measures for reducing its spread, researchers need detailed data on the course of the pandemic. Standard public health data streams suffer inconsistent reporting and frequent, unexpected revisions. They also miss other aspects of a population’s behavior that are worthy of consideration. We present an open database of COVID signals in the United States, measured at the county level and updated daily. This includes traditionally reported COVID cases and deaths, and many others: measures of mobility, social distancing, internet search trends, self-reported symptoms, and patterns of COVID-related activity in deidentified medical insurance claims. The database provides all signals in a common, easy-to-use format, empowering both public health research and operational decision-making.
Constructing local cell-specific networks from single-cell data
Authors: Wang Xuran , Choi David , Roeder Kathryn 
Published: December 2021

Significance
Understanding gene regulatory networks is a topic of great interest because it can provide insights into cellular development, and identify factors that differ between normal and abnormal cells and phenotypes. Single-cell RNA sequencing provides a unique opportunity to gain understanding at the cellular level, but the technical features of the data create severe challenges when constructing gene networks. We develop a method that successfully skirts these challenges to estimate a cell-specific network for each single cell and cell type. Application of our algorithm to two brain cell samples furthers our understanding of autism spectrum disorder by examining the evolution of gene networks in fetal brain cells and comparing the networks of cells sampled from case and control subjects.
Theta activity paradoxically boosts gamma and ripple frequency sensitivity in prefrontal interneurons
Authors: Merino Ricardo Martins , Leon-Pinzon Carolina , Stühmer Walter , Möck Martin , Staiger Jochen F. , Wolf Fred , Neef Andreas 
Published: December 2021

Significance
Rhythmic brain activity is a signature of information processing. Common inhibitory cells, spike-frequency adapting interneurons, are typically thought to only participate in low-frequency rhythms (<10 Hz). However, we found that these cells’ frequency preference can be switched from 2 to 200 Hz. The switch occurs when low-frequency components dominate the interneurons’ input, as is the case during brain states of slow-wave sleep or quiet rest. These interneurons not only increase their sensitivity to input in the 30 to 200 Hz range (gamma and ripples) they do so within a few dozen milliseconds, in phase with the low-frequency input components. Our findings reveal unexpected flexibility in neurons, which could shape theta-gamma cross-frequency coupling, a phenomenon thought to contribute to information routing.
Responses within activities
Authors: Marmorstein Michal , Matalon Nadav 
Published: December 2021

AbstractLarge conversational activities (e.g., storytelling) necessitate a suspension of ordinary turn-taking rules. In the resulting constellation of main speaker and recipient, minimal displays of cooperative recipiency become relevant at particular junctures. We investigate this mechanism by focusing on the Egyptian Arabic particleʔāh‘yeah’ when thus used. We observe that tokens ofʔāhare mobilized by main speakers via the opening of prosodic slots at local pragmatic completion points. The prosodic design of the particle at these points is sensitive to prior talk and displays recipients’ alignment at the structural, action-sequential, and relational levels. This is done through variation of three prosodic features, namely, rhythm-based timing, pitch configuration, and prominence. The measure of alignment proposed byʔāhis implicative for the continuation of the turn. While smooth progression suggests thatʔāhis understood to be sufficiently fitted and aligned, expansions are traceable to a departure from the terms set by prior talk, which can be heard to indicate lesser alignment. We propose to viewʔāhresponse tokens as a subset of positionally sensitive responses to part-of-activity actions that are crucial for the co-accomplishment of a large activity.
Cross-sectional analysis of coping strategies and anxiety and depression levels in a sample of the Andalusian population during the home lockdown caused by the COVID-19 pandemic (Análisis transversal de las estrategias de afrontamiento y los niveles de ansiedad y depresión en una muestra de población andaluza durante el confinamiento domiciliario motivado por la pandemia de la COVID-19)
Authors: Zayas Antonio , Cruces-Montes Serafín J. , Paramio Alberto , Romero-Moreno Antonio , López-Sánchez José-Antonio , Gómez-Carmona Diego , Merchán-Clavellino Ana , Guil Rocío 
Published: December 2021

The restrictive measures put into place to control the COVID-19 pandemic in 2020 have prompted the need to study the possible health impacts in the middle term. Deprivation of the fundamental right to mobility results in an increase in affective disorders and the risks that they entail for the population. The goal of this study is to examine anxiety and depression levels during the first national lockdown and to determine the key coping strategies in order to develop health treatment and promotion programmes. The sample, comprised of 485 participants (mean age = 40) from Andalusia, received questionnaires via email between March and June. The results showed that acceptance, active coping and humour were the most effective coping strategies to explain and predict a decrease in anxiety and depression within the context of the home lockdown. Therefore, we recommend that these coping strategies be studied in order to develop programmes that help prevent the psychological consequences of the lockdown.
A multi-system weighted fusion method to improve measurement accuracy of structured light 3D profilometry
Authors: Xing Chao , Huang Junhui , Wang Zhao , Gao Jianmin 
Published: December 2021

Abstract
Improving the accuracy of three-dimensional profile measurement based on binary coded structured light for complex surfaces is a challenge. A new method of weighted fusion using multiple systems is presented to reduce the measurement errors due to the stripe grayscale asymmetry. It is based on the analysis of stripe center deviation related to the surface normal and the directions of incident and reflected rays. First, the stripe center deviation model is established according to the geometric relationship between the stripe center deviation and the incident and reflected angles at any measured point. The influence of each variable on stripe center deviation is analyzed, and three subsystems are formed by a binocular structured light framework to achieve multiple measurements based on the influence regularity. Then, in order to improve the measurement accuracy, different weights are assigned to the measured point in the different subsystems according to the stripe center deviation model and its relationship with the measurement error, and the weighted data from the different subsystems are fused. Experiments are carried out to validate the presented method, and the experimental results demonstrate that it effectively improves the measurement accuracy of complex surfaces. The measurement accuracy is improved by about 27% compared with the conventional method.
Au aerogel for selective CO2 electroreduction to CO: ultrafast preparation with high performance
Authors: Yan Shenglin , Mahyoub Samah A , Lin Jing , Zhang Chunxiao , Hu Qing , Chen Chengzhen , Zhang Fanghua , Cheng Zhenmin 
Published: December 2021

Abstract
Noble metal aerogels (NMAs) have been used in a variety of (photo-)electrocatalytic reactions, but pure Au aerogel (AG) has not been used in CO2 electroreduction to date. To explore the potential application in this direction, AG was prepared to be used as the cathode in CO2 electroreduction to CO. However, the gelation time of NMAs is usually very long, up to several weeks. Here, an excess NaBH4 and turbulence mixing-promoted gelation approach was developed by introducing magnetic stirring as an external force field, which therefore greatly shortened the formation time of Au gels to several seconds. The AG-3 (AG with Au loading of 0.003 g) exhibited a high CO Faradaic efficiency (FE) of 95.6% at an extremely low overpotential of 0.39 V, and over 91% of CO FE was reached in a wide window of −0.4 to −0.7 V versus the reversible hydrogen electrode (RHE). Partial current density in CO was measured to be −19.35 mA cm−2 at −0.8 V versus RHE under 1 atm of CO2. The excellent performance should be ascribed to its porous structure, abundant active sites, and large electrochemical active surface area. It provides a new method for preparation of AG with ultrafast gelation time and large production at room temperature, and the resulting pure AG was for the first time used in the field of CO2 electroreduction.
The role of cell–matrix interactions in connective tissue mechanics
Authors: Muntz Iain , Fenu Michele , van Osch Gerjo J V M , Koenderink Gijsje H 
Published: December 2021

Abstract
Living tissue is able to withstand large stresses in everyday life, yet it also actively adapts to dynamic loads. This remarkable mechanical behaviour emerges from the interplay between living cells and their non-living extracellular environment. Here we review recent insights into the biophysical mechanisms involved in the reciprocal interplay between cells and the extracellular matrix and how this interplay determines tissue mechanics, with a focus on connective tissues. We first describe the roles of the main macromolecular components of the extracellular matrix in regards to tissue mechanics. We then proceed to highlight the main routes via which cells sense and respond to their biochemical and mechanical extracellular environment. Next we introduce the three main routes via which cells can modify their extracellular environment: exertion of contractile forces, secretion and deposition of matrix components, and matrix degradation. Finally we discuss how recent insights in the mechanobiology of cell–matrix interactions are furthering our understanding of the pathophysiology of connective tissue diseases and cancer, and facilitating the design of novel strategies for tissue engineering.
Quantum uncertainty relations of Tsallis relative α entropy coherence based on MUBs
Authors: Zhang Fu-Gang 
Published: December 2021

Abstract
In this paper, we discuss quantum uncertainty relations of Tsallis relative α entropy coherence for a single qubit system based on three mutually unbiased bases. For

α
∈

1

2

,
1

∪
(
1
,
2
]

, the upper and lower bounds of sums of coherence are obtained. However, the above results cannot be verified directly for any

α
∈

0
,

1

2

. Hence, we only consider the special case of

α
=

1

n
+
1

, where n is a positive integer, and we obtain the upper and lower bounds. By comparing the upper and lower bounds, we find that the upper bound is equal to the lower bound for the special

α
=

1

2

, and the differences between the upper and the lower bounds will increase as α increases. Furthermore, we discuss the tendency of the sum of coherence, and find that it has the same tendency with respect to the different θ or φ, which is opposite to the uncertainty relations based on the Rényi entropy and Tsallis entropy.
e
+
e
−
γ production at photon-photon colliders at complete electroweak NLO accuracy *
Authors: Li He-Yi , Zhang Ren-You , Ma Wen-Gan , Jiang Yi , Li Xiao-Zhou 
Published: December 2021

Abstract
We present the NLO electroweak radiative corrections to the

production in γγ collision, which is an ideal channel for calibrating the beam luminosity of a Photon Linear Collider. We analyze the dependence of the total cross section on the beam colliding energy, and then investigate the kinematic distributions of final particles at various initial photon beam polarizations at EW NLO accuracy. The numerical results indicate that the EW relative corrections to the total cross section are non-negligible and become increasingly significant as the increase of the beam colliding energy, even can exceed –10% in the

γγ collision at

. Such EW corrections are very important and should be taken into consideration in precision theoretical and experimental studies at high-energy γγ colliders.