bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Multi-Point Surveillance for Antimicrobial Resistance Profiles among Clinical Isolates of Gram-Negative Bacteria Recovered from Major Ha’il Hospitals, Saudi Arabia
Authors: Said Kamaleldin B. , Alsolami Ahmed , Khalifa Amany M. , Khalil Nuha A. , Moursi Soha , Osman Abuzar , Fahad Dakheel , Rakha Ehab , Rashidi Musleh , Moussa Safia , Bashir Abdelhafiz I. , Alfouzan Fayez , Hammam Sahar , Taha Taha E. , Al-hazimi Awdah , Al Jadani Ahmed ,   On behalf of the Ha’il COM Research Unit Group
Published: September 2021

The devastating nosocomial resistance is an on-going global concern. Surveillance of resistance is crucial for efficient patient care. This study was aimed to conduct a surveillance in four major Ha’il Hospitals from September to December 2020. Using a multipoint program, records of 621 non-duplicate Gram-negative cultures were tested across 21 drugs belonging to different categories. Major species were Klebsiella pneumoniae (n = 187, 30%), E. coli (n = 151, 24.5%), Pseudomonas aeruginosa, (n = 84, 13.6%), Acinetobacter baumannii (n = 82, 13.3%), and Proteus mirabilis (n = 46, 7%). Based on recent resistance classifications, A. baumanni, P. aeruginosa, and enteric bacteria were defined as pan-resistant, extremely resistant, and multi-drug resistant, respectively. A. baumannii (35%) and K. pneumoniae (23%) dominated among coinfections in SARS-CoV2 patients. The “other Gram-negative bacteria” (n = 77, 12.5%) from diverse sources showed unique species-specific resistance patterns, while sharing a common Gram-negative resistance profile. Among these, Providencia stuartii was reported for the first time in Ha’il. In addition, specimen source, age, and gender differences played significant roles in susceptibility. Overall infection rates were 30% in ICU, 17.5% in medical wards, and 13.5% in COVID-19 zones, mostly in male (59%) senior (54%) patients. In ICU, infections were caused by P. mirabilis (52%), A. baumannii (49%), P. aeruginosa (41%), K. pneumoniae (24%), and E. coli (21%), and most of the respiratory infections were caused by carbapenem-resistant A. baumannii and K. pneumoniae and UTI by K. pneumoniae and E. coli. While impressive IC, hospital performances, and alternative treatment options still exist, the spread of resistant Gram-negative bacteria is concerning especially in geriatric patients. The high selective SARS-CoV2 coinfection by A. baumannii and K. pneumoniae, unlike the low global rates, warrants further vertical studies. Attributes of resistances are multifactorial in Saudi Arabia because of its global partnership as the largest economic and pilgrimage hub with close social and cultural ties in the region, especially during conflicts and political unrests. However, introduction of advanced inter-laboratory networks for genome-based surveillances is expected to reduce nosocomial resistances.
Plasmepsin-like Aspartyl Proteases in Babesia
Authors: Šnebergerová Pavla , Bartošová-Sojková Pavla , Jalovecká Marie , Sojka Daniel 
Published: September 2021

Apicomplexan genomes encode multiple pepsin-family aspartyl proteases (APs) that phylogenetically cluster to six independent clades (A to F). Such diversification has been powered by the function-driven evolution of the ancestral apicomplexan AP gene and is associated with the adaptation of various apicomplexan species to different strategies of host infection and transmission through various invertebrate vectors. To estimate the potential roles of Babesia APs, we performed qRT-PCR-based expressional profiling of Babesia microti APs (BmASP2, 3, 5, 6), which revealed the dynamically changing mRNA levels and indicated the specific roles of individual BmASP isoenzymes throughout the life cycle of this parasite. To expand on the current knowledge on piroplasmid APs, we searched the EuPathDB and NCBI GenBank databases to identify and phylogenetically analyse the complete sets of APs encoded by the genomes of selected Babesia and Theileria species. Our results clearly determine the potential roles of identified APs by their phylogenetic relation to their homologues of known function—Plasmodium falciparum plasmepsins (PfPM I–X) and Toxoplasma gondii aspartyl proteases (TgASP1–7). Due to the analogies with plasmodial plasmepsins, piroplasmid APs represent valuable enzymatic targets that are druggable by small molecule inhibitors—candidate molecules for the yet-missing specific therapy for babesiosis.
Salt Stress Amelioration in Maize Plants through Phosphogypsum Application and Bacterial Inoculation
Authors: Khalifa Tamer , Elbagory Mohssen , Omara Alaa El-Dein 
Published: September 2021

The use of phosphogypsum (PG) and plant growth-promoting rhizobacteria (PGPR) for agricultural purposes are good options to improve soil properties and increase crop yield. The objective of this study was to investigate the effect of different rates of PG (ton ha−1; 0 (PG1), 3 (PG2), 6 (PG3), and 9 (PG4)) combined with PGPR inoculation (Azospirillum lipoferum (control, T1), A. lipoferum + Bacillus coagulans (T2), A. lipoferum + B. circulance (T3), and A. lipoferum + B. subtilis (T4)) on soil properties, plant physiology, antioxidant enzymes, nutrient uptake, and yield of maize plants (Zea mays L., cv. HSC 10) grown in salt-affected soil. Over two growing seasons, 2019 and 2020, field experiments were conducted as a split-plot design with triplicates. The results show that applying PG (9 ton ha−1) and co-inoculation (A. lipoferum + B. circulance) treatment significantly increased chlorophyll and carotenoids content, antioxidant enzymes, microbial communities, soil enzymes activity, and nutrient contents, and showed inhibitory impacts on proline content and pH, as well as EC and ESP, thus improving the productivity of maize plant compared to the control treatment. It could be concluded that PG, along with microbial inoculation, may be an important approach for ameliorating the negative impacts of salinity on maize plants.
Potential Adjuvant Therapeutic Effect of Lactobacillus plantarum Probio-88 Postbiotics against SARS-COV-2
Authors: Rather Irfan A. , Choi Sy-Bing , Kamli Majid Rasool , Hakeem Khalid Rehman , Sabir Jamal S. M. , Park Yong-Ha , Hor Yan-Yan 
Published: September 2021

In response to the ongoing COVID-19 pandemic, the global effort to develop high efficacy countermeasures to control the infection are being conducted at full swing. While the efficacy of vaccines and coronavirus drugs are being tested, the microbiome approach represents an alternative pathophysiology-based approach to prevent the severity of the infection. In the current study, we evaluated the action of a novel probiotic Lactobacillus plantarum Probio-88 against SARS-COV-2 replication and immune regulation using an in vitro and in silico study. The results showed that extract from this strain (P88-CFS) significantly inhibited the replication of SARS-COV-2 and the production of reactive oxygen species (ROS) levels. Furthermore, compared with infected cells, P88-CFS treated cells showed a significant reduction in inflammatory markers such as IFN-α, IFN-β, and IL-6. Using an in silico molecular docking approach, it was postulated that the antiviral activity of L. plantarum Probio-88 was derived from plantaricin E (PlnE) and F (PlnF). The high binding affinity and formation of hydrogen bonding indicated that the association of PlnE and PlnF on SARS-COV-2 helicase might serve as a blocker by preventing the binding of ss-RNA during the replication of the virus. In conclusion, our study substantiated that P88-CFS could be used as an integrative therapeutic approach along with vaccine to contain the spread of the highly infectious pathogen and possibly its variants.
RELATIONSHIP AMONG DENSITY MEASUREMENTS AND COMPOSITION OF DIFFERENT MEATS
Authors: Torres-Vargas Olga Lucía , Barat-Baviera José Manuel , Aliño Marta 
Published: September 2021

Composition of fresh and frozen meat products, specially fat content, is one of the parameters that is usually taken into account for different purposes such as classification of fresh and frozen meat pieces for fresh consume as well as for processing, price fixation and adequacy for processing. That is the reason why some different non destructive methods are used to determine, at least approximately, the meat composition. Among them, we can go from visual methods to the more complex resonance imaging and computed tomography image analysis.
The aim of this study was to use density measurement as a non destructive, easy and cheap method to classify fresh and frozen meat with a wide range of fat content. The obtained results showed that there is asignificant relationship between density and fat content of fresh and frozen meat.
Evaluación del impacto económico de producción de pastos mejorados perennes en los productores agropecuarios
Authors: Cotrina Cabello Víctor Raúl , Puente-Segura Santiago Oscar , Cotrina Cabell Guillermo Gomer 
Published: September 2021

El objetivo de investigación fue evaluar el impacto económico de la producción de pastos mejorados en los productores agropecuarios, los métodos usado fueron deductivo - inductivo con su técnica de revisión documental y sus respectivos instrumentos de la estadística descriptiva, los resultados de los aspectos sociales; en la variable nivel de instrucción de los productores tiene poca influencia en la producción de pastos; miembros que trabajan en la unidad agrícola 54% son padres de familia y 16% son madres de familia responsables de cosecha; con respecto a la disponibilidad de agua para riego el 56% no disponen. En el aspecto de la producción para mejora de calidad de vida se evaluó la variable del rendimiento de pastos mejorados 28% tiene un rendimiento 30 - 35 tonelada por hectárea con seis cosechas al año y la mejora de ingresos económicos de los productores, el 40% es regular y 53% es bueno; en la contratación de hipótesis no existe diferencia estadística significativa. Se concluye, la producción de pastos no influye favorable en el impacto económico significativamente en el productor.
Provision of Kidney Disease Education Service Is Associated with Improved Vascular Access Outcomes among US Incident Hemodialysis Patients
Authors: Ruchi Rupam , Bozorgmehri Shahab , Chamarthi Gajapathiraju , Orozco Tatiana , Mohandas Rajesh , Ozrazgat-Baslanti Tezcan , Segal Mark S. , Shukla Ashutosh M. 
Published: September 2021

Background
Pre-ESKD Kidney Disease Education (KDE) has been shown to improve multiple CKD outcomes, but its effect on vascular access outcomes is not well studied. In 2010, Medicare launched KDE reimbursements policy for patients with advanced CKD.

Methods
In this retrospective USRDS analysis, we identified all adult patients on incident hemodialysis with ≥6 months of pre-ESKD Medicare coverage during the first 5 years of CMS-KDE policy and divided them into CMS-KDE services recipients (KDE cohort) and nonrecipients (non-KDE cohort). The primary outcome was incident arteriovenous fistula (AVF) and the composite of incident AVF or arteriovenous graft (AVG) utilization. Secondary outcomes were central venous catheter (CVC) with maturing AVF/AVG and pure CVC utilizations. Step-wise multivariate analyses were performed in four progressive models (model 1, KDE alone; model 2, multivariate model encompassing model 1 with sociodemographics; model 3, model 2 with comorbidity and functional status; and model 4, model 3 with pre-ESKD nephrology care).

Results
Of the 211,990 qualifying patients on incident hemodialysis during the study period, 2887 (1%) received KDE services before dialysis initiation. The rates of incident AVF and composite AVF/AVG were more than double (30% and 35%, respectively, compared with 14% and 17%), and pure catheter use about a third lower (40% compared with 65%) in the KDE cohort compared with the non-KDE cohort. The maximally adjusted odds ratios in model 4 for study outcomes were incident AVF use, 1.78, 99% confidence interval, 1.55 to 2.05; incident AVF/AVG use, 1.78, 99% confidence interval, 1.56 to 2.03; incident CVC with maturing AVF/AVG, 1.69, 99% confidence interval, 1.44 to 1.97; and pure CVC without any AVF/AVG, 0.51, 99% confidence interval, 0.45 to 0.58. The benefits of the KDE service were maintained even after accounting for the presence, duration, and facility of ESKD care.

Conclusion
The occurrence of pre-ESRD KDE service is associated with significantly improved incident vascular access outcomes. Targeted studies are needed to examine the effect of KDE on patient engagement and self-efficacy as a cause for improvement in vascular access outcomes.
ANALYSIS OF ITU-T AND ITU-R RECOMMENDATIONS ON FIFTH-GENERATION COMMUNICATION NETWORKS. PART I
Authors: ТОНКИХ Е.В. 
Published: September 2021

Публикация представляет собой первую часть статьи,посвященной деятельности Международного союза электросвязи (МСЭ)в области стандартизации сетей связи пятого поколения и дальнейших перспективных разработок. Рассмотрены ключевые документы МСЭ-R, заложившие основу для исследований и разработки как радиоинтерфейсов, так и сетевой архитектуры сетей 5G/IMT-2020, ориентированной на качественно новые функции и услуги. Результаты нашли свое отражение в документах фокус-групп и в рекомендациях МСЭ-Т.
This publication is the first part of an article devoted to the International Telecommunication Union (ITU) activity on the standardization of fifth-generation communication networks and further promising developments. The key ITU-R documents, which laid the foundation for research and development of both radio interfaces and the network architecture of 5G/IMT-2020 networks, focused on qualitatively new functions and services, are considered. The results are reflected in ITU-T focus group papers and ITU-T Recommendations.
Comprehensive Chemistry of HeH+ in the Early Universe*
Authors: Courtney E. D. S. , Forrey R. C. , McArdle R. T. , Stancil P. C. , Babb J. F. 
Published: September 2021

Abstract
The recent detection of the helium hydride ion (HeH+) in the planetary nebula NGC 7027 has inspired studies revisiting the dominant processes for its formation and destruction. Because radiative association is the primary formation mechanism for the helium hydride ion at all redshifts, and many early universe chemistry models rely on accurate results for calculations of destruction rates, we explicitly computed rovibrationally distinguished partial cross sections and rate coefficients of helium hydride formation via radiative association, and modeled the abundance of HeH+ in the early universe using recently available rate coefficients for all relevant formation and destruction reactions. The rate coefficients for the radiative association formation reaction of HeH+ and radiative charge transfer in He+ + H collisions were obtained using two distinct methods. Our newly calculated rate coefficients along with other recently reported He chemistry reactions and updated cosmological parameters were incorporated into a new calculation of the abundance of HeH+ for redshifts between z = 10 and 4000. We find that the abundance of the helium hydride ion is at least three orders of magnitude larger than previous predictions for redshifts near z = 20. Rovibrationally distinguished radiative association rate coefficients are given as a function of temperature, and the significance of stimulated radiative association for redshifts z > 400 is also shown.
Ultra-delayed Neutrino-driven Explosion of Rotating Massive-star Collapse
Authors: Fujibayashi Sho , Takahashi Koh , Sekiguchi Yuichiro , Shibata Masaru 
Published: September 2021

Abstract
Long-term neutrino-radiation hydrodynamics simulations in full general relativity are performed for the collapse of rotating massive stars that are evolved from He-stars with initial masses of 20 and 32 M
⊙. It is shown that if the collapsing stellar core has sufficient angular momentum, the rotationally supported proto-neutron star (PNS) survives for seconds accompanying the formation of a massive torus of mass larger than 1 M
⊙. Subsequent mass accretion onto the central region produces a massive and compact central object, and eventually enhances the neutrino luminosity beyond 1053 erg s−1, resulting in a very delayed neutrino-driven explosion, in particular toward the polar direction. The kinetic energy of the explosion can be appreciably higher than 1052 erg for a massive progenitor star and compatible with that of energetic supernovae like broad-line type-Ic supernovae. By the subsequent accretion, the massive PNS collapses eventually into a rapidly spinning black hole, which could be a central engine for gamma-ray bursts if a massive torus surrounds it.
Simulating the Eclipsing Binary Yields of the Rubin Observatory in the Galactic Field and Star Clusters
Authors: Geller Aaron M. , Polzin Ava , Bowen Andrew , Miller Adam A. 
Published: September 2021

Abstract
We present a study of the detection and recovery efficiency of the Rubin Observatory for detached eclipsing binaries (EBs) in the galactic field, globular clusters (GCs), and open clusters (OCs), with a focus on comparing two proposed observing strategies: a standard cadence (baseline) and a cadence that samples the galactic plane more evenly (colossus). We generate realistic input binary populations in all observing fields of the Rubin Observatory, simulate the expected observations in each filter, and attempt to characterize the EBs using these simulated observations. In our models, we predict that the baseline cadence will enable the Rubin Observatory to observe about three million EBs; our technique could recover and characterize nearly one million of these in the field and thousands within star clusters. If the colossus cadence is used, the number of recovered EBs would increase by an overall factor of about 1.7 in the field and in globular clusters, and a factor of about 3 in open clusters. Including semidetached and contact systems could increase the number of recovered EBs by an additional factor of about 2.5 to 3. Regardless of the cadence, observations from the Rubin Observatory could reveal statistically significant physical distinctions between the distributions of EB orbital elements between the field, GCs, and OCs. Simulations such as these can be used to bias correct the sample of Rubin Observatory EBs to study the intrinsic properties of the full binary populations in the field and star clusters.
The Observed Cosmic Star Formation Rate Density Has an Evolution that Resembles a Γ(a, bt) Distribution and Can Be Described Successfully by Only Two Parameters
Authors: Katsianis Antonios , Yang Xiaohu , Zheng Xianzhong 
Published: September 2021

Abstract
A debate is emerging regarding the recent inconsistent results of different studies for the cosmic star formation rate density (CSFRD) at high-z. We employ UV and IR data sets to investigate the SFR function (SFRF) at z ∼ 0–9. We find that the SFRFs derived from the dust-corrected UV (UVcorr) data contradict those from IR on some key issues because they are described by different distributions (Schechter versus double power law), imply different physics for galaxy formation (UVcorr data suggest an SFR limit/strong mechanism that diminish the number density of highly star-forming systems with respect to IR) and compare differently with the stellar mass density evolution obtained from spectral energy distribution fitting (UVcorr is in agreement, while IR differs up to 0.5 dex). However, both tracers agree on a constant CSFRD evolution at z ∼ 1–4 and point to a plateau instead of a peak. In addition, using both indicators, we demonstrate that the evolution of the observed CSFRD can be described by only two parameters and a function that has the form of a Gamma distribution (Γ(a, bt)). In contrast to previous parameterizations used in the literature, our framework connects the parameters to physical properties such as the SFR depletion time and cosmic baryonic gas density. The build-up of stellar mass occurs in Γ(a, bt) distributed steps and is the result of gas consumption up to the limit at which no eligible gas for SF at t = ∞ remains, resulting in a final cosmic stellar mass density of ∼

0.5
×

10

9

M

⊙

Mpc

3

.
The 59Fe (n,γ) 60Fe Cross Section from the Surrogate Ratio Method and Its Effect on the 60Fe Nucleosynthesis
Authors: Yan 颜 S. Q. 胜权 , Li 李 X. Y. 鑫悦 , Nishio K. , Lugaro M. , Li 李 Z. H. 志宏 , Makii H. , Pignatari M. , Wang 王 Y. B. 友宝 , Orlandi R. , Hirose K. , Tsukada K. , Mohr P. , Li 李 G. S. 广顺 , Wang 王 J. G. 建国 , Gao 高 B. S. 丙水 , Han 韩 Y. L. 银录 , Guo 郭 B. 冰 , Li 李 Y. J. 云居 , Shen 谌 Y. P. 阳平 , Sato T. K. , Ito Y. , Suzaki F. , Su 苏 J. 俊 , Yang 杨 Y. Y. 彦云 , Wang 王 J. S. 建松 , Ma 马 J. B. 军兵 , Ma 马 P. 朋 , Bai 白 Z. 真 , Xu 许 S. W. 世伟 , Ren 任 J. 杰 , Fan 樊 Q. W. 启文 , Zeng 曾 S. 晟 , Han 韩 Z. Y. 治宇 , Nan 南 W. 巍 , Nan 南 W. K. 威克 , Chen 陈 C. 晨 , Lian 连 G. 钢 , Hu 胡 Q. 强 , Duan 段 F. F. 芳芳 , Jin 金 S. Y. 树亚 , Tang 唐 X. D. 晓东 , Liu 柳 W. P. 卫平 
Published: September 2021

Abstract
The long-lived 60Fe (with a half-life of 2.62 Myr) is a crucial diagnostic of active nucleosynthesis in the Milky Way galaxy and in supernovae near the solar system. The neutron-capture reaction 59Fe(n,γ)60Fe on 59Fe (half-life = 44.5 days) is the key reaction for the production of 60Fe in massive stars. This reaction cross section has been previously constrained by the Coulomb dissociation experiment, which offered partial constraint on the E1 γ-ray strength function but a negligible constraint on the M1 and E2 components. In this work, for the first time, we use the surrogate ratio method to experimentally determine the 59Fe(n,γ)60Fe cross sections in which all the components are included. We derived a Maxwellian-averaged cross section of 27.5 ± 3.5 mb at kT = 30 keV and 13.4 ± 1.7 mb at kT = 90 keV, roughly 10%–20% higher than previous estimates. We analyzed the impact of our new reaction rates in nucleosynthesis models of massive stars and found that uncertainties in the production of 60Fe from the 59Fe(n,γ)60Fe rate are at most 25%. We conclude that stellar physics uncertainties now play a major role in the accurate evaluation of the stellar production of 60Fe.
The MACH Hi Absorption Survey. I. Physical Conditions of Cold Atomic Gas outside of the Galactic Plane
Authors: Murray Claire E. , Stanimirović Snežana , Heiles Carl , Dickey John M. , McClure-Griffiths N. M. , Lee M.-Y. , M. Goss W. , Killerby-Smith Nicholas 
Published: September 2021

Abstract
Tracing the transition between the diffuse atomic interstellar medium and cold, dense gas is crucial for deciphering the star formation cycle in galaxies. Here we present Measuring Absorption by Cold Hydrogen (MACH), a new survey of cold neutral hydrogen (HI) absorption at 21 cm by the Karl G. Jansky Very Large Array. We target 42 bright background sources with 60 < l < 110°, 30 < b < 62°, significantly expanding the sample of publicly available, sensitive 21 cm absorption outside the Galactic plane. With matching 21 cm emission data from the Effelsberg-Bonn Hi (EBHiS) Survey, we measure the total column density and cold Hi fraction, and quantify the properties of individual Hi structures along each sightline via autonomous Gaussian decomposition. Combining the MACH sample with results from recent Hi absorption surveys, we produce a robust characterization of the cool atomic medium at high and intermediate Galactic latitudes. We find that MACH Hi has significantly smaller column density relative to samples at similar latitudes, and the detected cold Hi structures have smaller line widths, temperatures, and turbulent Mach numbers, suggesting that MACH probes a particularly quiescent region. Using all available observations, we compute the cumulative covering fraction (c) of cold Hi at local velocities outside the disk: structures with τ > 0.001 are ubiquitous (c ∼ 100%), whereas high optical depths (τ > 1) are extremely rare (c ∼ 0%).