bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling the elusive: X‐rays bring scolecophidian snakes out of the dark
Authors: Bell Christopher J. , Daza Juan D. , Stanley Edward L. , Laver Rebecca J. 
Published: September 2021

AbstractScolecophidian snakes have long posed challenges for scholars interested in elucidating their anatomy. The importance, and relative paucity, of high‐quality anatomical data pertaining to scolecophidians was brought into sharp focus in the late 20th century as part of a controversy over the phylogeny and ecological origin of snakes. The basal position of scolecophidians in the phylogeny of snakes makes their anatomy, behavior, ecology, and evolution especially important for such considerations. The depauperate fossil record for the group meant that advances in understanding their evolutionary history were necessarily tied to biogeographic distributions and anatomical interpretations of extant taxa. Osteological data, especially data pertaining to the skull and mandible, assumed a dominant role in shaping historical and modern perspectives of the evolution of scolecophidians. Traditional approaches to the exploration of the anatomy of these snakes relied heavily upon serial‐sectioned specimens and cleared‐and‐stained specimens. The application of X‐ray computed tomography (CT) to the study of scolecophidians revolutionized our understanding of the osteology of the group, and now, via diffusible iodine‐based contrast‐enhanced computed tomography (diceCT), is yielding data sets on internal soft anatomical features as well. CT data sets replicate many aspects of traditional anatomical preparations, are readily shared with a global community of scholars, and now are available for unique holotype and other rare specimens. The increasing prevalence and relevance of CT data sets is a strong incentive for the establishment and maintenance of permanent repositories for digital data.
Deception attack monitoring in vulnerable hydroelectric generator system
Authors: Sari Bilal , Sid Mohamed Amine 
Published: September 2021

AbstractThis article deals with unknown deception attacks detection of hydroelectric generator. Such cyber attacks are switching disturbances that affect the input information transmitted from the power system stabilizer to the plant through a constrained communication network. The generator dynamics can be modeled as an augmented state model, whereas the unknown input reconstruction is obtained from a modified Kalman filter recursions under communication constraints. The obtained design ensures the minimization of disturbances with accurate cyberattack monitoring.
Erneuerung einer festen Fahrbahn der Bahn unter Verwendung von UHFB – weltweit erstmaliger Einsatz von UHFB im Gleisbau – Teil 2: Übersicht der statischen Nachweise, Dimensionierung der hochleistungsfähigen Schwellensockel aus UHFB
Authors: Hochuli Antonina , Trouillet Jean‐Georges , Brühwiler Eugen , Schulz Olaf , Hoffmann Michael 
Published: September 2021

AbstractDieser Aufsatz in zwei Teilen berichtet über die Instandsetzung und Anpassung der festen Fahrbahn im stark frequentierten unterirdischen Bahnhof Zürich Flughafen. Die 1980 eingebaute feste Fahrbahn hatte die vom Systemanbieter vorausgesagte Nutzungsdauer erreicht und wies Schäden auf. Damit die Bahnsteige die Vorgaben des Behindertengleichstellungsgesetzes (BehiG) erfüllen, musste außerdem die Gleisgeometrie abschnittweise durch eine Absenkung angepasst werden. Aus diesem Grund war ein einfacher Austausch der Schwellenblöcke nicht möglich und eine Sonderlösung erforderlich. Mit der Anwendung des ultrahochleistungsfähigen zementgebundenen Faserverbundbaustoffs UHFB wurde eine nachhaltige und wirtschaftliche Lösung für ein Projekt gefunden, bei dem eine traditionelle Lösung zeit‐ und kostenaufwendig gewesen wäre. Außerdem wurde im Rahmen dieses Projekts festgestellt, dass die Anwendung des UHFB mit deutlich verbesserten mechanischen Eigenschaften die Nutzungsdauer der festen Fahrbahn erhöht. Mit dem Einsatz von UHFB wird die Nutzungsdauer der festen Fahrbahn gleich derjenigen der gesamten Bahnhofanlage, was die Wirtschaftlichkeit weiter verbessert. In diesem Teil wird das Vorgehen bei der Bemessung der Sockel aus UHFB erläutert. Die einzelnen Punkte der Dimensionierung der Sockel aus traditionellem Beton C50/60 werden ebenfalls erwähnt.
Verstärkung einer Spannbetonbrücke mit Carbonbeton – Erweiterte Rechenmethoden zum Ankündigungsverhalten von Brücken mit spannungsrisskorrosionsgefährdetem Spannstahl
Authors: Steinbock Oliver , Wetzel Timm 
Published: September 2021

AbstractNeue Entwicklungen und umgesetzte Verstärkungsmaßnahmen zeigen das Potenzial von Carbonbeton für die Ertüchtigung von Brücken im Bestand. Im Jahr 2020 wurden zunächst zwei Brückenbauwerke im Zuge der BAB A 648 mit Carbonbeton verstärkt. Im Jahr 2021 wird das dritte Teilbauwerk ebenfalls mit Carbonbeton verstärkt. Planung und Konzeption der Verstärkungsmaßnahme mit Carbonbeton zur Sicherstellung eines ausreichenden Ankündigungsverhaltens bei Spannungsrisskorrosion sind Gegenstand des Beitrags. Aufgrund der besonderen Konstruktionsform des Tragwerks kamen im Hinblick auf die Untersuchung des Ankündigungsverhaltens erweiterte Rechenmethoden zum Einsatz. Das Tragwerk mit kurzen Endfeldern ist repräsentativ für zahlreiche Bauwerke im Bestand. Aufgrund der ungünstigen Stützweitenverhältnisse ergeben sich bei der Anwendung der sog. Handlungsanweisung Spannungsrisskorrosion für Straßenbrücken rechnerische Defizite bzw. Anwendungsgrenzen bei den Verfahren. Für den vorliegenden Fall wurde daher eine Monte‐Carlo‐Simulation zur Untersuchung des Ankündigungsverhaltens durchgeführt und in Verbindung mit einer Verstärkungsmaßnahme mit Carbonbeton auch sichergestellt. Der vorliegende Beitrag fasst die rechnerische Vorgehensweise zusammen und zeigt die planerische Umsetzung der Verstärkungsmaßnahme.
The enigmatic Placozoa part 1: Exploring evolutionary controversies and poor ecological knowledge
Authors: Schierwater Bernd , Osigus Hans‐Jürgen , Bergmann Tjard , Blackstone Neil W. , Hadrys Heike , Hauslage Jens , Humbert Patrick O. , Kamm Kai , Kvansakul Marc , Wysocki Kathrin , DeSalle Rob 
Published: September 2021

AbstractThe placozoan Trichoplax adhaerens is a tiny hairy plate and more simply organized than any other living metazoan. After its original description by F.E. Schulze in 1883, it attracted attention as a potential model for the ancestral state of metazoan organization, the “Urmetazoon”. Trichoplax lacks any kind of symmetry, organs, nerve cells, muscle cells, basal lamina, and extracellular matrix. Furthermore, the placozoan genome is the smallest (not secondarily reduced) genome of all metazoan genomes. It harbors a remarkably rich diversity of genes and has been considered the best living surrogate for a metazoan ancestor genome. The phylum Placozoa presently harbors three formally described species, while several dozen “cryptic” species are yet awaiting their description. The phylogenetic position of placozoans has recently become a contested arena for modern phylogenetic analyses and view‐driven claims. Trichoplax offers unique prospects for understanding the minimal requirements of metazoan animal organization and their corresponding malfunctions.
Yield improvement of enediyne yangpumicins in Micromonospora yangpuensis through ribosome engineering and fermentation optimization
Authors: Wang Zilong , Sun Runze , Li Miao , Liu Ling , Duan Yanwen , Huang Yong 
Published: September 2021

AbstractYangpumicins (YPMs), for example, YPM A, F, and G, are newly discovered enediynes from Micromonospora yangpuensis DSM 45577, which could be exploited as promising payloads of antibody‐drug conjugates. However, the low yield of YPMs in the wild‐type strain (∼1 mg L−1) significantly hampers their further drug development. In this study, a combined ribosome engineering and fermentation optimization strategy has been used for yield improvement of YPMs. One gentamicin‐resistant M. yangpuensis DSM 45577 strain (MY‐G‐1) showed higher YPMs production (7.4 ± 1.0 mg L−1), while it exhibits delayed sporulation and slender mycelium under scanning electron microscopy. Whole genome re‐sequencing of MY‐G‐1 reveals several deletion and single nucleotide polymorphism mutations, which were confirmed by PCR and DNA sequencing. Further Box–Behnken experiment and regression analysis determined that the optimal medium concentrations of soluble starch, D‐mannitol, and pharmamedia for YPMs production in shaking flasks (10.0 ± 0.8 mg L−1). Finally, the total titer of YPM A/F/G in MY‐G‐1 reached to 15.0 ± 2.5 mg L−1 in 3 L fermenters, which was about 11‐fold higher than the original titer of 1.3 ± 0.3 mg L−1 in wild‐type strain. Our study may be instrumental to develop YPMs into a clinical anticancer drug, and inspire the use of these multifaceted strategies for yield improvement in Micromonospora species.Graphical Abstract Lay Summary
???image???
Meta‐fermentation system with a mixed culture for the production of optically pure l‐lactic acid can be reconstructed using the minimum isolates with a simplified pH control strategy
Authors: Yue Siyuan , Mizoguchi Takaharu , Kohara Toshiya , Zhang Min , Watanabe Kota , Miyamoto Hirokuni , Tashiro Yukihiro , Sakai Kenji 
Published: September 2021

AbstractMeta‐l‐lactic acid fermentation from non‐treated kitchen refuse was reconstructed using a combination of isolated bacterial strains under several pH control strategies. The meta‐fermentation system was successfully reconstructed using a combination of Weizmannia coagulans MN‐07, Caldibacillus thermoamylovorans OM55‐6, and Caldibacillus hisashii N‐11 strains. Additionally, a simplified constant pH control strategy was employed, which decreased fermentation time and increased production. The optimum pH (6.5) for the reconstructed meta‐fermentation was favorable for the respective pure cultures of the three selected strains. The l‐lactic acid production performance of the reconstructed meta‐fermentation system was as follows: concentration, 24.5 g L−1; optical purity, 100%; productivity, 0.341 g L−1 h−1; yield, 1.06 g g−1. These results indicated that constant pH control was effective in the reconstructed meta‐fermentation with the best performance of l‐lactic acid production at pH optimal for the selected bacterial growth, while the switching from swing pH control would suppress the activities of unfavorable bacterial species in un‐isolated meta‐fermentation.
Advances in topiramate as prophylactic treatment for migraine
Authors: Hu Chuan , Zhang Yixin , Tan Ge 
Published: September 2021

AbstractIt is well‐known that topiramate as a kind of antiepileptic drug has been proved effective for migraine prevention in North America and Europe. However, topiramate is still viewed as an off‐label medication for migraine treatment in China, partly because of the limited evidence in Chinese patients. We summarize the effects of topiramate on the frequency, severity, quality‐of‐life, and adverse event among migraine patients, including children and adolescent in this review, so as to provide reference for Chinese doctors.
Psychosocial factors and cancer incidence (PSY‐CA): Protocol for individual participant data meta‐analyses
Authors: van Tuijl Lonneke A. , Voogd Adri C. , de Graeff Alexander , Hoogendoorn Adriaan W. , Ranchor Adelita V. , Pan Kuan‐Yu , Basten Maartje , Lamers Femke , Geerlings Mirjam I. , Abell Jessica G. , Awadalla Philip , Bakker Marije F. , Beekman Aartjan T. F. , Bjerkeset Ottar , Boyd Andy , Cui Yunsong , Galenkamp Henrike , Garssen Bert , Hellingman Sean , Huisman Martijn , Huss Anke , Keats Melanie R. , Kok Almar A. L. , Luik Annemarie I. , Noisel Nolwenn , Onland‐Moret N. Charlotte , Payette Yves , Penninx Brenda W. J. H. , Portengen Lützen , Rissanen Ina , Roest Annelieke M. , Rosmalen Judith G. M. , Ruiter Rikje , Schoevers Robert A. , Soave David M. , Spaan Mandy , Steptoe Andrew , Stronks Karien , Sund Erik R. , Sweeney Ellen , Teyhan Alison , Vaartjes Ilonca , van der Willik Kimberly D. , van Leeuwen Flora E. , van Petersen Rutger , Verschuren W. M. Monique , Visseren Frank , Vermeulen Roel , Dekker Joost 
Published: September 2021

AbstractObjectivesPsychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking‐related, and alcohol‐related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer.MethodsThe psychosocial factors and cancer incidence (PSY‐CA) consortium was established involving experts in the field of (psycho‐)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two‐stage individual participant data (IPD) meta‐analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta‐analyses will be performed on the risk estimates (stage 2).ConclusionPSY‐CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta‐analyses.
Effect of omega‐3 and vitamin D co‐supplementation on psychological distress in reproductive‐aged women with pre‐diabetes and hypovitaminosis D: A randomized controlled trial
Authors: Rajabi‐Naeeni Masoumeh , Dolatian Mahrokh , Qorbani Mostafa , Vaezi Amir Abbas 
Published: September 2021

AbstractPurposePsychological distresses and pre‐diabetes are among the risk factors of developing type‐II diabetes. The present study was conducted to determine the effectiveness of omega‐3 and vitamin D co‐supplementation on psychological distresses in women of reproductive age with pre‐diabetes and hypovitaminosis D.MethodsThe present factorial clinical trial was conducted on 168 women of reproductive age with pre‐diabetes and hypovitaminosis D. These participants were selected by stratified random sampling and were assigned to four groups for 8 weeks: group 1 (placebo group), group 2 (omega‐3 group), group 3 (vitamin D group), and group 4 (co‐supplement group). The medication and placebo doses being two 1000‐mg tablets each day for omega‐3 and 50,000‐IU pearls every 2 weeks for vitamin D. Fasting blood glucose and vitamin D were measured at the beginning of the study. The Depression Anxiety Stress Scale‐21 and the Pittsburgh Sleep Quality Index were completed by the participants at the start and end of the intervention.ResultsA significant difference was observed in terms of reduction in anxiety and improvement in sleep quality in the co‐supplementation compared to the other three groups (p < .05). There was also a significant difference between the group receiving both supplements and the group receiving only placebos in terms of reduction in depression and stress (p < .05).ConclusionVitamin D and omega‐3 co‐supplementation improved depression, anxiety, and sleep quality in women of reproductive age with pre‐diabetes and hypovitaminosis D. Therefore, these two supplements can be recommended for improving the mental health of this group of women.Clinical trial registryIranian Registry of Clinical Trials Code: IRCT20100130003226N17. Registered on February 9, 2019.
Studying green marketing in emerging economies
Authors: Sedky Dalia , AbdelRaheem Mohamed Abdallah 
Published: September 2021

AbstractGreen marketing, from the researchers' point of view, can be defined as the equation of achieving profits, satisfying customers, and at the same time keeping the environment safe. There is a great concern about sustainability all over the world, which pushes the researchers to study green marketing in emerging economies. This research study examines how green marketing can affect consumer's purchase decision. Four hundred printed copies of the questionnaire have been collected complete and valid for analysis. Factor analysis, reliability test, and multiple regression analysis have been done using SPSS software. It has been found that consumers can be encouraged to buy green products if they feel that these products will have a positive impact on their health. Business companies need to organize marketing campaigns which highlight the healthy gains obtained from acquiring green products to increase their sales. Eco‐labeling and point of purchase of green products are also elements that can affect consumer's purchase decision. This research study can help companies to achieve profits and at the same time keep the environment safe. This research study has the potential for presenting interesting insights into the challenge of influencing consumers in non‐Western markets. This research study displays the literature of green marketing in some emerging economies and tests it in a new context (Egypt). It can be concluded that each emerging economy has a unique nature when applying green marketing.
Blood pressure lowering with alcohol‐mediated renal denervation using the Peregrine infusion Catheter is independent of injection site location
Authors: Mahfoud Felix , Bertog Stefan , Lauder Lucas , Böhm Michael , Schmid Axel , Wojakowski Wojciech , Parise Helen , Fischell Tim A. , Kandzari David E. , Pathak Atul , Persu Alexandre , Sievert Horst 
Published: September 2021

AbstractObjectivesThe current analysis utilized core laboratory angiographic data from a prospective, single‐arm, open‐label, multi‐center feasibility study to ascertain whether the location of alcohol infusion within main renal arteries during renal denervation (RDN) had an impact on the BP‐lowering effect at 6 months.BackgroundThe influence of the location of alcohol infusion during RDN, within the main renal artery (proximal, middle, or distal), on the magnitude of the blood pressure (BP) lowering is unstudied.MethodsThe Peregrine Catheter was used to perform alcohol‐mediated RDN with an infusion of 0.6 mL of alcohol per artery as the neurolytic agent in 90 main arteries and four accessory arteries of 45 patients with hypertension.ResultsNo relationship between the site of alcohol infusion and change from baseline in both office systolic and 24‐hour systolic ambulatory BP (ABP) at 6 months was observed. When analyzed at the artery level, the least squares (LS) mean changes ± SEM from baseline to 6 months post‐procedure in 24‐hour systolic ABP when analyzed by renal arterial location were −11.9 ± 2.4 mmHg (distal), −10 ± 1.6 mmHg (middle), and −10.6 ± 1.3 mmHg (proximal) (all p < 0.0001 for change from baseline within groups). The results were similar for office systolic BP. There was no difference between treated locations (proximal is reference).ConclusionIn this post‐hoc analysis, the location of alcohol infusion within the main renal artery using the Peregrine system, with alcohol as the neurolytic agent for chemical RDN, did not affect the magnitude of BP changes at 6 months.
Operational Experiences with a Temperature‐Variable District Heating Network for a Rural Community
Authors: Werner Melanie , Ehrenwirth Mathias , Muschik Sebastian , Trinkl Christoph , Schrag Tobias 
Published: September 2021

AbstractThe potential of utilizing temperature‐variable district heating systems in rural areas was investigated. A local district heating system in Germany and the related project NATAR are briefly described; measurement data is evaluated. Operational experiences with a seasonal temperature reduction and consequent advantages for different heat generation systems and heat storages are discussed. The analysis of measurement data reveals a high optimization potential for solar thermal systems in case of an integration both into a low‐ and a high‐temperature storage. Furthermore, a combined heat‐and‐power plant in combination with a CO2 heat pump promises sector‐coupling potential and high electricity self‐consumption.
Cost‐Effective Adsorption of Oxidative Coupling‐Derived Ethylene Using a Molecular Sieve
Authors: Siakavelas Georgios I. , Georgiadis Amvrosios G. , Charisiou Nikolaos D. , Yentekakis Ioannis V. , Goula Maria A. 
Published: September 2021

AbstractThe adsorption of ethylene (C2H4) from a mixture simulating the products obtained during the oxidative coupling of CH4 using a commercial molecular sieve (MOS) is investigated. A joint experimental and theoretical approach has been employed. The adsorbent's trapping capacity decreases at higher temperatures, while the breakpoint time drops when the inlet C2H4 concentration increases. The Dubinin‐Radushkevich isotherm model can better describe the adsorption of C2H4 onto the MOS. Pore diffusion is the rate‐determining step given that the Bangham's kinetic model was the more suitable for this adsorption process. Finally, the low activation energy obtained corroborates the predominance of physical adsorption.
An experimental study on the effect of gas injection configuration on flow characteristics in high viscosity oil columns
Authors: Mohammed Shara K. , Hasan Abbas H. , Ibrahim Abubakr , Dimitrakis Georgios 
Published: September 2021

AbstractGas‐viscous liquid bubbly and slug flow are very common in petroleum, chemical, bioengineering, polymer, and food processing. However, there is a major knowledge gap in two‐phase flow research in the design of gas injectors/distributers in very high viscosity oil systems. The present study investigates the effect of gas injection methods in columns containing very high viscosity oils (i.e., realistic liquids), and more specifically using 360 Pa · s viscosity oil in a 240‐mm diameter column. The effects that the radial positioning, number of gas nozzles, and their distance from each other have on the structure of the flow in viscous liquids are presented in detail. Electrical capacitance tomography (ECT) is used to extract experimental data. Void fraction, bubble velocity, frequency, liquid film thickness, and bubble length were measured and analyzed at different radial gas injection positions. It has been observed that bubble length increases significantly by 0.3 m when the injection nozzle is located next to the wall of the pipe. Bubble velocity and length also increase by 0.217 m/s and 3.6 m, respectively, with increasing gas flowrate when multiple injection points are used. Increasing the distance between the gas injection points increased bubbles' length by 1.2 m. Bubbles' velocity and frequency (at higher gas flow rate) were also increased.