bluuebunny/crossref_metadata_2025_split huggingface dataset:
Focal Boost to the Intraprostatic Tumor in External Beam Radiotherapy for Patients With Localized Prostate Cancer: Results From the FLAME Randomized Phase III Trial
Authors: Kerkmeijer Linda G. W. , Groen Veerle H. , Pos Floris J. , Haustermans Karin , Monninkhof Evelyn M. , Smeenk Robert Jan , Kunze-Busch Martina , de Boer Johannes C. J. , van der Voort van Zijp Jochem , van Vulpen Marco , Draulans Cédric , van den Bergh Laura , Isebaert Sofie , van der Heide Uulke A. 
Published: January 2021

PURPOSE This study investigates whether focal boosting of the macroscopic visible tumor with external beam radiotherapy increases biochemical disease-free survival (bDFS) in patients with localized prostate cancer. PATIENTS AND METHODS In the phase III, multicenter, randomized controlled Focal Lesion Ablative Microboost in Prostate Cancer trial, 571 patients with intermediate- and high-risk prostate cancer were enrolled between 2009 and 2015. Patients assigned to standard treatment received 77 Gy (fractions of 2.2 Gy) to the entire prostate. The focal boost arm received an additional simultaneous integrated focal boost up to 95 Gy (fractions up to 2.7 Gy) to the intraprostatic lesion visible on multiparametric magnetic resonance imaging. Organ at risk constraints were prioritized over the focal boost dose. The primary end point was 5-year bDFS. Secondary end points were disease-free survival (DFS), distant metastases-free survival, prostate cancer-specific survival, overall survival, toxicity, and health-related quality of life. RESULTS Median follow-up was 72 months. Biochemical DFS was significantly higher in the focal boost compared with the standard arm (hazard ratio 0.45, 95% CI, 0.28 to 0.71, P < .001). At 5-year follow-up bDFS was 92% and 85%, respectively. We did not observe differences in prostate cancer-specific survival ( P = .49) and overall survival ( P = .50). The cumulative incidence of late genitourinary and GI toxicity grade ≥ 2 was 23% and 12% in the standard arm versus 28% and 13% in the focal boost arm, respectively. Both for late toxicity as health-related quality of life, differences were small and not statistically significant. CONCLUSION The addition of a focal boost to the intraprostatic lesion improved bDFS for patients with localized intermediate- and high-risk prostate cancer without impacting toxicity and quality of life. The Focal Lesion Ablative Microboost in Prostate Cancer study shows that a high focal boost strategy to improve tumor control while respecting organ at risk dose constraints is effective and safe.
Harnessing brain development to understand brain tumours
Authors: Marino Silvia , Gilbertson Richard J. 
Published: January 2021

ABSTRACTBrain tumours are the commonest solid neoplasms in children, accounting for one quarter of all childhood cancers. Our growing knowledge of basic developmental mechanisms has significantly contributed to understanding the pathogenesis of these tumours and is beginning to impact clinical decisions on how children with these diseases are treated.
Oxygen regulates epithelial stem cell proliferation via RhoA-actomyosin-YAP/TAZ signal in mouse incisor
Authors: Otsu Keishi , Ida-Yonemochi Hiroko , Ikezaki Shojiro , Ema Masatsugu , Hitomi Jiro , Ohshima Hayato , Harada Hidemitsu 
Published: January 2021

ABSTRACT
Stem cells are maintained in specific niches that strictly regulate their proliferation and differentiation for proper tissue regeneration and renewal. Molecular oxygen (O2) is an important component of the niche microenvironment, but little is known about how O2 governs epithelial stem cell (ESC) behavior. Here, we demonstrate that O2 plays a crucial role in regulating the proliferation of ESCs using the continuously growing mouse incisors. We have revealed that slow-cycling cells in the niche are maintained under relatively hypoxic conditions compared with actively proliferating cells, based on the blood vessel distribution and metabolic status. Mechanistically, we have demonstrated that, during hypoxia, HIF1α upregulation activates the RhoA signal, thereby promoting cortical actomyosin and stabilizing the adherens junction complex, including merlin. This leads to the cytoplasmic retention of YAP/TAZ to attenuate cell proliferation. These results shed light on the biological significance of blood-vessel geometry and the signaling mechanism through microenvironmental O2 to orchestrate ESC behavior, providing a novel molecular basis for the microenvironmental O2-mediated stem cell regulation during tissue development and renewal.
Robustness and timing of cellular differentiation through population-based symmetry breaking
Authors: Stanoev Angel , Schröter Christian , Koseska Aneta 
Published: January 2021

ABSTRACT
During mammalian development and homeostasis, cells often transition from a multilineage primed state to one of several differentiated cell types that are marked by the expression of mutually exclusive genetic markers. These observations have been classically explained by single-cell multistability as the dynamical basis of differentiation, where robust cell-type proportioning relies on pre-existing cell-to-cell differences. We propose a conceptually different dynamical mechanism in which cell types emerge and are maintained collectively by cell-cell communication as a novel inhomogeneous state of the coupled system. Differentiation can be triggered by cell number increase as the population grows in size, through organisation of the initial homogeneous population before the symmetry-breaking bifurcation point. Robust proportioning and reliable recovery of the differentiated cell types following a perturbation is an inherent feature of the inhomogeneous state that is collectively maintained. This dynamical mechanism is valid for systems with steady-state or oscillatory single-cell dynamics. Therefore, our results suggest that timing and subsequent differentiation in robust cell-type proportions can emerge from the cooperative behaviour of growing cell populations during development.
Frequency and characterization of ancillary chest CT findings in COVID-19 pneumonia
Authors: Silva Mario , Ledda Roberta Eufrasia , Schiebler Mark , Balbi Maurizio , Sironi Sandro , Milone Francesca , Affanni Paola , Milanese Gianluca , Sverzellati Nicola 
Published: January 2021

Objectives:
Ground-glass opacity and consolidation are recognized typical features of Coronavirus disease-19 (COVID-19) pneumonia on Chest CT, yet ancillary findings have not been fully described. We aimed to describe ancillary findings of COVID-19 pneumonia on CT, to define their prevalence, and investigate their association with clinical data.

Methods:
We retrospectively reviewed our CT chest cases with coupled reverse transcriptase polymerase chain reaction (rt-PCR). Patients with negative rt-PCR or without admission chest CT were excluded. Ancillary findings included: vessel enlargement, subpleural curvilinear lines, dependent subpleural atelectasis, centrilobular solid nodules, pleural and/or pericardial effusions, enlarged mediastinal lymph nodes. Continuous data were expressed as median and 95% confidence interval (95% CI) and tested by Mann–Whitney U test.

Results:
Ancillary findings were represented by 106/252 (42.1%, 36.1 to 48.2) vessel enlargement, 50/252 (19.8%, 15.4 to 25.2) subpleural curvilinear lines, 26/252 (10.1%, 7.1 to 14.7) dependent subpleural atelectasis, 15/252 (5.9%, 3.6 to 9.6) pleural effusion, 15/252 (5.9%, 3.6 to 9.6) mediastinal lymph nodes enlargement, 13/252 (5.2%, 3 to 8.6) centrilobular solid nodules, and 6/252 (2.4%, 1.1 to 5.1) pericardial effusion. Air space disease was more extensive in patients with vessel enlargement or centrilobular solid nodules (p &lt; 0.001). Vessel enlargement was associated with longer history of fever (p = 0.035) and lower admission oxygen saturation (p = 0.014); dependent subpleural atelectasis with lower oxygen saturation (p &lt; 0.001) and higher respiratory rate (p &lt; 0.001); mediastinal lymph nodes with shorter history of cough (p = 0.046); centrilobular solid nodules with lower prevalence of cough (p = 0.023), lower oxygen saturation (p &lt; 0.001), and higher respiratory rate (p = 0.032), and pericardial effusion with shorter history of cough (p = 0.015). Ancillary findings associated with longer hospital stay were subpleural curvilinear lines (p = 0.02), whereas centrilobular solid nodules were associated with higher rate of intensive care unit admission (p = 0.01).

Conclusion:
Typical high-resolution CT findings of COVID-19 pneumonia are frequently associated with ancillary findings that variably associate with disease extent, clinical parameters, and disease severity.

Advances in knowledge:
Ancillary findings might reflect the broad range of heterogeneous mechanisms in severe acute respiratory syndrome from viral pneumonia, and potentially help disease phenotyping.
Modeling and Solving the Intersection Inspection Rural Postman Problem
Authors: Sinha Roy Debdatta , Masone Adriano , Golden Bruce , Wasil Edward 
Published: January 2021

Local governments inspect roads to decide which segments and intersections to repair. Videos are taken using a camera mounted on a vehicle. The vehicle taking the videos proceeds straight or takes a left turn to cover an intersection fully. We introduce the intersection inspection rural postman problem (IIRPP), which is a new variant of the rural postman problem (RPP) that involves turns. We develop integer programming formulations of the IIRPP based on two different graph transformations to generate least-cost vehicle routes. One formulation is based on a new idea of transforming a graph. A second formulation is based on a graph transformation idea from the literature. Computational experiments show that the formulation involving the new graph transformation idea performs much better than the other formulation. We also develop an RPP-based heuristic and a heuristic based on a modified RPP. Heuristic solutions are improved by solving integer programming formulations on an induced subgraph. Computational experiments show that the heuristics based on the modified RPP perform much better than the RPP-based heuristics. The best-performing heuristic generates very good quality IIRPP-feasible routes on large street networks quickly. Summary of Contribution. Our paper addresses a real-world problem faced by local governments during road inspections. The real-world problem that we solve and the methodologies that we use fall at the intersection of computing and operations research. We introduce the intersection inspection rural postman problem, which is a new variant of the rural postman problem that involves turns to capture this real-world scenario. The rural postman problem is an important problem in vehicle routing. Studying new variants of this problem is key to extending the practice and theory of vehicle routing. We develop an integer programming formulation based on a new idea of transforming a graph and also develop heuristics based on the rural postman problem.
The Power of Opaque Products in Pricing
Authors: Elmachtoub Adam N. , Hamilton Michael L. 
Published: January 2021

We study the power of selling opaque products, that is, products where a feature (such as color) is hidden from the customer until after purchase. Opaque products, which are sold with a price discount, have emerged as a powerful vehicle to increase revenue for many online retailers and service providers that offer horizontally differentiated items. In the opaque selling models we consider, all of the items are sold at a single common price alongside opaque products that may correspond to various subsets of the items. We consider two types of customers, risk-neutral ones, who assume they will receive a truly random item of the opaque product, and pessimistic ones, who assume they will receive their least favorite item of the opaque product. We benchmark opaque selling against two common selling strategies: discriminatory pricing, where one explicitly charges different prices for each item, and single pricing, where a single price is charged for all the items. We give a sharp characterization of when opaque selling outperforms discriminatory pricing; namely, this result holds for situations where all customers are pessimistic or the item valuations are supported on two points. In the latter case, we also show that opaque selling with just one opaque product guarantees at least 71.9% of the revenue from discriminatory pricing. We then provide upper bounds on the potential revenue increase from opaque selling strategies over single pricing and describe cases where the increase can be significantly more than that of discriminatory pricing. Finally, we provide pricing algorithms and conduct an extensive numerical study to assess the power of opaque selling for a variety valuation distributions and model extensions. This paper was accepted by Gabriel Weintraub, revenue management and market analytics.
Three-dimensional gravity tailored ultra-broadband absorber based on a high-impedance surface
Authors: Zhang Hao , Tian Xingliang , Zhang Haifeng , Zhang Dan 
Published: January 2021

In this paper, we present a novel, to the best of our knowledge, 3D ultra-broadband tunable metamaterial absorber (TMA), which is innovatively tuned by the gravity field with changing the position of the liquid metal (eutectic gallium-indium) in theory. The given TMA consists of a 3D glass cavity filled with the liquid metal, two-layer high-impedance surfaces, two dielectric layers, and a metallic plate on the bottom. The ultra-broadband absorption is achieved by the high-impedance surface and the liquid metal. Furthermore, it is noted that the liquid metal is poured into the different parts of the glass cavities via rotation under the action of the gravity field to obtain the tunable absorption. When such a TMA is not rotated, for the TE wave, the absorption rate exceeds 90% from 1.8 to 57.5 GHz with a wide relative absorption bandwidth (AB) of 187.8%. However, for the TM wave, the absorptivity goes beyond 90% at 5.6–56.4 GHz. The proposed TMA exhibits ultra-broadband absorption in the frequency regime of 1.6–45.3 GHz (the absorption rate is higher than 90%) with such a TMA rotated 180° in the

x

−

y

plane, while the absorption rate is near zero from 1.6 to 60 GHz when the proposed TMA is rotated 180° in the

y

−

z

plane. Moreover, the surface current distributions, the near-field amplitude

|

E
z

|

, the phase

φ
z

, and the magnetic field distributions are investigated to describe the operating mechanism of the designed TMA. Besides, the numerical results indicate that such a TMA can realize high absorption under a wider incident angle. Compared with traditional tunable devices, the gravity field regulation, which can change the operating frequencies of an absorber in a noncontact way, has the advantages of easy implementation and resource savings. The proposed absorber tuned by the gravity will have potential applications in frequency selection. With the change of liquid metal and structure design, this design can also be potentially applied in other microwave and terahertz devices. Taken together, this study suggests a role for such an absorber in promoting a novel application for tunable devices.
Treatment outcomes of drug susceptible Tuberculosis in private health facilities in Lagos, South-West Nigeria
Authors: Oladimeji Olanrewaju , Adepoju Victor , Anyiam Felix Emeka , San James Emmanuel , Odugbemi Babatunde A. , Hyera Francis Leonard Mpotte , Sibiya Maureen Nokuthula , Yaya Sanni , Zoakah Ayuba Ibrahim , Lawson Lovett 
Published: January 2021

BackgroundThe Lagos State Tuberculosis, Buruli Ulcer, and Leprosy Control Program (LSTBLCP) started engaging private hospitals under the Public-Private Mix (PPM) Program in 2008. The study aimed to evaluate the trend and predictors of successful Tuberculosis (TB) treatment outcomes of patients managed across these private health facilities between 2010–2016 in Lagos, Nigeria.MethodsRetrospective review of TB treatment register and treatment cards of patients commenced on TB treatment between January 2010 and December 2016 in 36 private health facilities engaged by the LSTBLCP. Between December 2016 and February 2017, data were collected and entered into Microsoft Excel by trained data entry clerks. The analysis was done using SPSS software. Independent predictors of successful treatment outcomes were determined using multivariate analysis at the statistical significance of p<0.05 and 95% confidence interval.ResultsA total of 1660 records of TB patients were reviewed. 1535 (92.47%) commenced treatment, while 1337 (87.10%) of all records had documented treatment outcomes. Of the 1337 patients with outcomes, 1044 (78.09%) had a successful treatment outcome, and 293 (21.91%) had an unsuccessful outcome. Majority were male, 980 (59.04%), Human Immunodeficiency Virus (HIV) negative status, 1295 (80.24%), diagnosed with smear, 1141 (73.14%), treated in private not-for-profit (PNFP) hospital, 1097 (66.08%), treated for TB between 2014–2016 (18.96%-19.52%). In multivariate analysis, age>20years (aOR = 0.26, p = 0.001), receiving TB treatment in 2013 (aOR = 0.39, p = 0.001), having genexpert for TB diagnosis (aOR = 0.26, p = 0.031) and being HIV positive (aOR = 0.37, p = 0.001) significantly reduced likelihood of successful treatment outcome. The site of TB, being on ART or CPT, were confounding determinants of successful treatment outcomes as they became non-significant at the multivariate analysis level.ConclusionTreatment outcome among Lagos private hospitals was low compared with NTBLCP and World Health Organization (WHO) target. We urge the government and TB stakeholders to strengthen the PPM interventions to improve adherence, particularly among People Living with HIV (PLHIV) and older TB patients. Hence, promotion of early care-seeking, improving diagnostic and case holding efficiencies of health facilities, and TB/HIV collaborative interventions can reduce the risk of an unsuccessful outcome.
Identifying intentional injuries among children and adolescents based on Machine Learning
Authors: Yin Xiling , Ma Dan , Zhu Kejing , Li Deyun 
Published: January 2021

Background
Compared to other studies, the injury monitoring of Chinese children and adolescents has captured a low level of intentional injuries on account of self-harm/suicide and violent attacks. Intentional injuries in children and adolescents have not been apparent from the data. It is possible that there has been a misclassification of existing intentional injuries, and there is a lack of research literature on the misclassification of intentional injuries. This study aimed to discuss the feasibility of discriminating the intention of injury based on Machine Learning (ML) modelling and provided ideas for understanding whether there was a misclassification of intentional injuries.

Methods
Information entropy was used to determine the correlation between variables and the intention of injury, and Naive Bayes (NB), Decision Tree (DT), Random Forest (RF), Adaboost algorithms and Deep Neural Networks (DNN) were used to create an intention of injury discrimination model. The models were compared by comprehensively testing the discrimination effect to determine stability and consistency.

Results
For the area under the ROC curve with different intentions of injuries, the NB model was 0.891, 0.880, and 0.897, respectively; the DT model was 0.870, 0.803, and 0.871, respectively; the RF model was 0.850, 0.809, and 0.845, respectively; the Adaboost model was 0.914, 0.846, and 0.914, respectively; the DNN model was 0.927, 0.835, and 0.934, respectively. In a comprehensive comparison of the five models, DNN and Adaboost models had higher values for the determination of the intention of injury. A discrimination of cases with unclear intentions of injury showed that on average, unintentional injuries, violent attacks, and self-harm/suicides accounted for 86.57%, 6.81%, and 6.62%, respectively.

Conclusion
It was feasible to use the ML algorithm to determine the injury intention of children and adolescents. The research suggested that the DNN and Adaboost models had higher values for the determination of the intention of injury. This study could build a foundation for transforming the model into a tool for rapid diagnosis and excavating potential intentional injuries of children and adolescents by widely collecting the influencing factors, extracting the influence variables characteristically, reducing the complexity and improving the performance of the models in the future.
Subsequent Primary Cancers of the Digestive System Among Childhood and Adolescent Cancer Survivors From 1975 to 2015 in the United States
Authors: Liu Jason J. , Chen Chuan-Yu , Giovannucci Edward , Wu Chun-Ying 
Published: January 2021

INTRODUCTION:
Among survivors from first primary cancers that occurred during childhood and adolescence, their risks of developing subsequent primary digestive system cancers are not well understood. Therefore, we conducted the largest and most comprehensive analysis examining risks for diverse types of digestive system cancers after survival from a wide variety of first primary childhood and adolescent cancers.

METHODS:
We identified 41,249 patients diagnosed with first primary cancer from 1975 to 2015 before 20 years of age from 9 Surveillance, Epidemiology and End Results Program registries. Standardized incidence ratios (SIRs) and absolute excess risks (AERs) for digestive system cancers were calculated controlling for age, sex, race, and calendar year.

RESULTS:
Among 41,249 cancer survivors, 133 developed subsequent primary digestive system cancer, with a median digestive system cancer diagnosis age of 37 years. The SIR and AER for any digestive system cancer were highest among survivors of bone cancer, lymphoma, and neuroblastoma. Among survivors from any first primary cancer, the SIR was significantly elevated for cancer of the esophagus, stomach, small intestine, large intestine, liver, and pancreas, whereas the AER was highest for large intestine cancer.

DISCUSSION:
Childhood and adolescent cancer survivors diagnosed from 1975 to 2015 have significantly elevated risks of digestive system cancers compared with the US general population. Our detailed findings may contribute to surveillance recommendations of childhood and adolescent cancer survivors and promote future studies to further understand mechanisms by which having various first primary cancers lead to subsequent primary digestive system cancers.