bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of electrocardiography from the coronary sinus in interventional treatment of coronary arteries: two-year experience of clinical application of the method
Authors: Shevchenko Yu. L. , Ermakov D. Yu. , Marchak D. I. 
Published: March 2021

The aimof this study was to summarize, systematize, and extend analysis of data of two-year clinical use of intracardiac ECG (ECG-CS) in patients with coronary artery disease.Material and methods.131 patients with coronary artery disease who underwent a planned coronary stenting were included in a prospective study from 2018 till 2020 . Ischemia was monitored with the use of electrophysiological recording system with the following settings: combining electrodes into fi ve cathode-anode pairs with a frequency range of 30–500 Hz, signal cut-off of 1 cm, and an amplitude of 0.3 mV/cm.Results.According to the ROC-analysis, the sensitivity of the ECG-СS method in case of ST segment depression was 79.5%, the specifi city was 100%; with ST segment elevation — 83% with a specifi city of 100%, according to data obtained in 88 patients with single-vessel disease of the coronary arteries (CA). Out of 43 patients with coronary artery disease, compromise of the diagonal branch and signifi cant ischemic dynamics (p < 0.05) in the intracardiac lead CS 3–4 after stent placement in the ADA according to ECG-CS was observed in 11 (25.6%) patients, in 9 (20.9%) of which successful provisional stenting was performed, and 2 (4 .6%) patients required implantation of the second stent.Conclusion.ECG-CS is a promising method for detecting myocardial ischemia in patients with coronary artery disease and allows to optimize intervention in the area of coronary artery bifurcation.
Peculiar features of arterial hypertension state on the background of atherosclerosis (clinical and instrumental comparisons)
Authors: Kryukov E. V. , Potekhin N. P. , Fursov A. N. , Chernov S. A. , Zakharova E. G. 
Published: March 2021

A comparative analysis of the clinical and functional state of patients with arterial hypertension (AH), depending on the presence or absence of arterial sclerotic disease of the arterial bed is represented. 2 groups of 110 and 60 patients respectively were formed. The 1st group included persons with arterial hypertension (AH) and atherosclerotic changes in the arterial bed, the 2nd — with hypertension and without any atherosclerotic changes. It is shown that patients with hypertension and stenotic changes of the vascular bed are characterized by an increase in the levels of diastolic blood pressure and indicators of systolic and diastolic pressure load during the day. They have signs of structural changes in the cardiovascular system, as proved by indicators of arterial stiff ness, myocardium remodeling, circadian rhythms of blood pressure abnormalities, and, in addition, kidney damage in a chronic form of disease, stage 2–3.On the contrary, hypertension without atherosclerotic changes of the vascular bed is characterized by higher values of systolic blood pressure, increased variability of systolic and diastolic blood pressure during the day, and, in addition, atherogenic dislipoproteinemia and hyperuricemy within the metabolic syndrome are present. As a clinical sign of atherosclerotic vascular changes in patients with hypertension, more “severe” blood pressure is observed. It requires combined antihypertensive therapy, consisting of 3 or more groups of medications.
Iron metabolism, cytokine secretion in patients with rheumatologic pathology
Authors: Sakhin V. T. , Kryukov E. V. , Grigoryev M. A. , Kazakov S. P. , Sotnikov A. V. , Gordienko A. V. , Rukavitsyn O. A. 
Published: March 2021

Aim.To study the eff ect of hepcidin, soluble transferrin receptor (sTfR ), and cytokines on iron metabolism and the development of anemia in rheumatologic patients, to propose a working version of the classifi cation of anemia of chronic diseases (ACD) according to the major nosotropic factor.Material and methods.126 patients with rheumatic disease, 34 men (45.8 (36–54.9) years old), 92 women (49.5 (38–60) years old) were examined. Group 1 included 41 patients with ACD. Group 2 included 29 patients with the combination of ACD and IDA and 34 patients with iron defi ciency anemia (IDA). Group 3 included 34 patients with IDA and 29 — with the combination of ACD and IDA. Control group included 22 patients without anemia. Comparative analysis between groups with and without anemia and correlation analysis of hemogram parameters, iron metabolism, C-reactive protein (CRP), hepcidin, sTfR , interleukin-6 (IL-6), IL-1β, IL-10, interferon gamma (INF-γ) and tumor necrosis factor alpha (TNF-α) were performed.Results.In the ACD group, the concentrations of hepcidin, ferritin, CRP, IL-6 were increased in comparison with other groups. The correlation was revealed between erythrocytes, hemoglobin and IL-6 (r = −0.3 and −0.6), IL-10 (r = −0.4 and −0.4), INF-γ (r = −0.4 and −0.3), TNF-α (r = −0.3 and −0.3), hepcidin (r = −0.5 and −0.7), sTfR (r = −0.5 and −0.7). Dependence was shown between IL-6 and iron (r = –0.6), transferrin saturation index (TSI) (r = −0.5), ferritin (r = −0.5), CRP (r = 0.5), between TNF-α and TIBС (r = −0.6), transferrin (r = −0.6), ferritin (r = −0.7), between IL-1β and TIBC, ferritin, transferrin (r = −0.4). The correlation was noted between hepcidin and IL-6 (r = 0.5), IL-10 (r = 0.4), between sTfR and IL-6 (r = 0.4), IL-10 (r = 0.6), INF-γ (r = 0.4).Conclusion.The multicomponent genesis of anemia in patients with rheumatologic disease was detected. The signifi cance of disorders in iron metabolism, the eff ect of hepcidin, sTfR and cytokines on the development of anemia was found. A working version of ACD classifi cation (with a predominant iron defi ciency, with violations of the regulatory mechanisms of erythropoiesis, with insuffi cient production of erythropoietin) has been put forward.
Pendekatan Multilevel Sebagai Upaya Meningkatkan Pemberian ASI Eksklusif
Authors: Khamidah Nur , Prabandari Yayi Suryo , Nurdiati Detty Siti 
Published: March 2021

Increasing exclusive breastfeeding effort was continued in Jember district. Local government collaborates with USAID to increase breastfeeding promotion program. Health promotion program used multilevel approach. This study aimed to evaluate exclusive breastfeeding program and impact program to increasing breastfeeding in Jember district. This study method used cross sectional study in two population with mix method approach (qualitative and quantitative). Collecting qualitative data was using participative observation, indepth interview and focus group discussion to describing program. Collecting quantitative data was using questionare to evaluate impact program in two populations (120 respondent program and 125 respondent non program). Data was analyzed by open code in qualitative data. To analyzed quantitative data was used chi square. The research result shows that Health promotion program increased exclusive breastfeeding was using multilevel approach. In top level, implementation of the program was regulation government policy number 17, 2013 about save childbirth, initiation breastfeeding and exclusive breastfeeding. In the middle level implementing program by Jember health department and local government clinic through peer breastfeeding support, mother pregnant class and promote by midwife. Lower level evaluation result was that two population program and non program have different significant. Population who give program have 2,4 higher OR value in exclusive breastfeeding than population not give the program. Based on this research it can be concluded that multilevel approach can used to increasing exclusive breastfeeding until six month. Government support was needed to successful program.
Case Report: Gastric Wall Thickening: Radiological Diagnostic Challenges in Gastric Malignancy
Authors: Wirastuti Giri Putu Ayu Winda , Laksminingsih Nyoman Srie , Sitanggang Firman Parulian , Dewi I Gusti Ayu Sri Mahendra , Sumadi I Wayan Juli , Maker Luh Putu Iin Indrayani 
Published: March 2021

Gastric abnormalities show nonspecific gastrointestinal symptoms and similarly radiological findings. Intra and extra luminal gastric wall thickening are the most common finding in benign and malignant pathologic process. This aim of this case report was to describe several characteristics such as the location and size of the lesion, involvement of the gastric wall and surrounding structures, calcifications, and contrast enhancement pattern which can assist in radiological diagnosis. Several cases at our institution have similar gastrointestinal complaints, however, there were different lesions characteristic found in contrast enhanced abdominal CT scan. The first case 72-years-old man experienced hematemesis with radiologic finding diffuse gastric mucosal thickening as well as homogenous contrast enhancement but without calcification. The second case 37-years-old man complaint dizziness and melena with radiologic finding large tumor more than 10 cm in size, amorph calcification and heterogenous contrast enhancement. The last 60-years-old man case experienced melena and hematemesis, from abdominal CT scan showed irregular gastric mucosal thickening with heterogenous contrast enhancement and fat stranding around the lesion, without calcification. Methods used in these cases were contrast-enhanced abdominal CT scan, esophagogastroduodenoscopy (EGD), and biopsy in order to determine the diagnosis. Contrast-enhanced abdominal CT scan plays a vital role in describing the lesion characteristics which affects the determination of treatment options and future prognosis.
Studi Eksperimental Pengaruh Panjang Penyangga Magnet pada Getaran Batang dengan Eddy Current Tuned Mass Damper
Authors: Efendi Rizal , Noerpamoengkas Ardi , Maulana Hasan Syafik 
Published: March 2021

Getaran dengan amplitudo berlebih bersifat destruktif dan perlu direduksi. Pada penelitian ini, batang kantilever utama dieksitasi sehingga bergetar. Salah satu teknik peredam getaran yang diaplikasikan adalah dengan menggunakan Eddy Current Tuned Mass Damper (ECTMD). Batang kantilever tambahan diberikan untuk menyangga magnet dengan variasi panjang 100 mm, 150 mm, 200 mm. Arus Eddy ditimbulkan dengan menambah pelat tembaga di batang kantilever utama. Respon peralihan maksimal dan amplitudo respon tunak diperoleh. Batang kantilever penyangga magnet ini semakin panjang menyebabkan respon peralihan maksimal semakin kecil dan amplitudo respon tunak semakin kecil. Akibatnya, penurunan respon dibandingkan tanpa ECTMD juga semakin naik dan transmissibilitas semakin turun.
Pengaruh Citra Perguruan Tinggi dan Kualitas Jasa Terhadap Minat Beli di Universitas Muhammadiyah Gresik Melalui Kepercayaan sebagai Variabel Intervening (Studi Kasus di Universitas Muhammadiyah Gresik)
Authors: Desembrianita Eva , Nur Megawati Munir , Suyoto Suyoto , Adil Malikul , Mahjudin Mahjudin 
Published: March 2021

Penelitian ini bertujuan untuk mengetahui pengaruh citra perguruan tinggi dan kualitas jasa terhadap minat beli melalui kepercayaan sebagai variabel intervening. Penelitian ini menggunakan pendekatan kuantitatif. Populasi yang digunakan dalam penelitian ini adalah calon mahasiswa yang ada di kabupaten Gresik. Jumlah sampel sebanyak 100 orang dengan menggunakan purposive sampling berdasarkan kriteria-kriteria tertentu. Alat analisis yang digunakan dalam penelitian ini yaitu program analisis SPSS 15 for Windows. Hasil penelitian menunjukkan bahwa variabel citra perguruan tinggi dan kualitas jasa secara bersama-sama berpengaruh positif dan signifikan terhadap minat beli. Berdasarkan hasil analisis, variabel citra perguruan tinggi dan kualitas jasa berpengaruh secara tidak langsung terhadap minat beli melalui kepercayaan. Namun, nilai koefisien pengaruh total citra perguruan tinggi lebih kecil yaitu 0,161 jika dibandingkan dengan kualitas jasa 0,368 yang lebih besar.
Indicators of emotional burnout of pupils at the age of 15-17 years old and their dynamic changes during period of study in a modern school
Authors: Serheta I. V. , Bratkova O. Yu , Panchuk O. Y. , Skoruk R. V. , Shevchuk Yu. G. 
Published: March 2021

Burnout-syndrome is a state of physical, motivational and, above all, emotional exhaustion, which is characterized by impaired productivity/education, the presence of severe fatigue, insomnia and increased susceptibility to the formation of somatic diseases, as well as the use of psychoactive substances, in order to obtain temporary relief, which has a pronounced tendency to develop psychological or physiological dependence and the formation of suicidal behavior. The purpose of the work is to determine the leading indicators of emotional burnout of pupils aged 15-17 years and to establish the features of their dynamic changes during education in a modern school. The research using Boyko's personal questionnaire was conducted on the basis of a number of secondary schools located in Vinnytsia, during which 309 pupils (158 young women and 151 young men) at the age of 15-17 years old were supervised. The analysis of the obtained data involved the application of descriptive statistics procedures based on the use of the standard package of statistical analysis applications “Statistica 6.1” (licensed № AXX910A374605FA). The obtained data testify to the fact that the syndrome of emotional burnout is most often observed among pupils at the aged 15 and 17, and in terms of age and sex, mainly among young men compared to young women. The differences between the rates of young women and young men are probably to be explained by their greater emotional openness and greater resistance of the organism to the action of stressors in comparison with young men. On the other hand, high levels of emotional burnout among young men compared to young women testify to their inability to spend their emotions economically, to effectively resist the actions of traumatic environmental factors and social living conditions. It is determined that the level of emotional burnout of schoolchildren is high among young women – due to the high level of expression of the phase of resistance, which indicates the development of resistance to emotional stress, among young men – due to phases of stress and exhaustion, which indicates significant depletion of adaptation mechanisms. The identified trends determine the need to develop conceptual frameworks for overcoming the leading manifestations of emotional burnout, which involve the use of personality-oriented approaches to improve the individual's ability to cope with stress due to changing stereotypes of their own behavior, relationships and relationships with others. mastering stress management skills, learning relaxation techniques, introduction of psychohygienic correction measures to pupils’ daily activities.
Analysis of quality of life and dental health criteria components within the structure of complex expert assessment of the prosthetic treatment among patients with maxillofacial trauma in anamnesis
Authors: Brekhlichuk P. P. 
Published: March 2021

Lesions of the dento-alvelolar system, which develop in cases of traffic accidents, domestic, industrial or other traumatic injuries, leads to a sharp decrease in dental health, and consequently to the decrease in quality of life associated with post-traumatic changes in dental status. Purpose of work – to analyze the indicators of the integrated quality of life criterion associated with the state of dental health among dental prosthetically-rehabilitated patients with a history of maxillofacial (MF) traumatic injuries. The study sample was formed on the basis of the University Dental Clinic from a cohort of patients who sought dental care with the need for comprehensive prosthetic rehabilitation. According to the analysis of medical records of dental patients, 66 persons with a history of maxillofacial traumatic injuries were selected. In order to assess the integrated criterion of quality of life associated with dental health, among dental patients with a history of maxillofacial traumatic injuries, who received appropriate prosthetic treatment, surveys were conducted taking into account all domains of OHIP-14 (abbreviated to 14 questions version of the Oral Health Impact Profile questionnaire). Mandibular fractures and traumatic injuries of individual teeth (dislocations, fractures) were the most prevalent among study sample and corresponded to 31.8 % and 27.3 %, respectively. The main causes of maxillofacial traumatic injuries were domestic injuries (43.9 %), road traffic accidents (RTA) (37.9 %), criminal injuries (10.6 %), industrial-associated (4.5 %) and sports-associated injuries (3.0 %). Prosthetic rehabilitation of the vast majority of patients, which correspond to 56 persons (84.8 %), was performed using different types of fixed prosthetic constructions, such as crowns, bridges supported by natural teeth, or installed dental implants. Majority of patients 84.9-95.5 % demonstrated high indicators of the integrated criterion of quality of life associated with changes in dental health, despite the fact of previous surgical treatment of maxillofacial traumatic lesions. Thus, in the absence of secondary deformities after surgical treatment of maxillofacial traumatic lesions, prosthetic rehabilitation of patients with the use of fixed types of prosthetic constructions supported by natural teeth or installed dental implants helps to achieve high quality of life associated with changes in dental health. The use of complete or partial removable dentures for a similar purpose provokes a relative decrease within the integral criterion of quality of life in the structure of such domains, as physical pain, psychological discomfort and social incapacity, which is due to the peculiarities of removable prosthetic construction exploitation, retention and functioning.
Features of the girth sizes of the body in men with various forms of eczema
Authors: Ahmad Al-Omary Ala’a Osama , Dmitrenko S. V. , Drachuk O. P. , Yasko V. V. , Gunas I. V. 
Published: March 2021

Prediction of the occurrence of eczema and the development of its severe forms is possible by identifying its morphological markers in patients with various forms and severity of dermatosis and their comparison with healthy subjects. The aim of the study was to examine the differences in body girth sizes between healthy and/or eczema patients depending on the severity of dermatosis. Patients with idiopathic (n=34) and microbial (n=38) eczema men of the first mature age underwent an anthropometric examination according to Bunak. The diagnosis of eczema was made according to the nomenclature of ICD-10. As a control from the data bank of the research center of National Pirogov Memorial Medical University, Vinnytsya anthropometric data of 82 practically healthy men of the same age group were selected. Statistical data processing was performed in the license package “Statistica 5.5” using non-parametric methods of evaluation of the obtained results. In healthy men, the following values of the following envelope sizes were found: shoulder girth in a tense state by 4.9 % compared with patients with severe eczema; unstressed shoulder girth by 7.3 % and 11.8 % compared with patients with idiopathic eczema of mild and severe course and by 10.0 % and 11.3% compared with patients with microbial eczema of mild and severe course; forearm girth in the upper part by 5.4 % compared with patients with idiopathic eczema of severe course; thigh girth by 5.1 % and 8.0 % compared with patients with idiopathic eczema of mild and severe course and by 7.1 % and 11.3 % compared with patients with microbial eczema of mild and severe course; thigh girth by 4.16 % and 4.5 % compared with patients with idiopathic severe eczema and mild microbial eczema; upper crus girth by 5.3 %, 7.5 % and 7.1 % compared with patients with idiopathic eczema of mild and severe course and microbial eczema of mild course; lower crus girth by 6.0 % compared with patients with mild microbial eczema; neck girth by 7.5 % and 6.8 % compared with patients with idiopathic severe eczema and mild microbial eczema; waist girth by 8.6 % and 15.6 % compared with patients with idiopathic eczema of mild and severe course and by 13.9 % and 16.7 % compared with patients with microbial eczema of mild and severe course; chest girth on inhalation, exhalation, at rest by 6.9 %, 9.5 % and 9.1 % compared with patients with idiopathic eczema of severe course. Only the girth of the foot in healthy men is 3.1 % higher than in sick men with mild microbial eczema. In men with idiopathic eczema, the neck girth was 5.4 % lower than in men with severe eczema. The obtained data can be used for a personalized approach in the creation of appropriate prevention and treatment and diagnostic programs.
Features of the hormonal background of women with infertility on the background of endometriosis and methods of their correction
Authors: Kulyk I. I. , Khmil S. V. 
Published: March 2021

Endometriosis-associated infertility is characterized by a number of specific features that must be considered when choosing treatment methods. In each case, treatment should be individual, taking into account all clinical factors, as well as the impact of the disease and the effect of treatment on the quality of woman’s life. Objective – to analyze the concentration of the reproductive system hormones in women with endometriosis-associated infertility before and after sclerotherapy using pregravidary preparation with a complex vitamin medication with inositol and vitamin D3. The study included 70 women aged 21-40 years with endometriosis-associated infertility. The comparison group included 30 women with tuboperitoneal infertility factor. Determination of the concentration of the reproductive system hormones was performed in an accredited laboratory of the “Professor S. Khmil Clinic Medical Center” with the help of “Diagnostic Systems Laboratories, Inc.” test system (USA) using the analyzer “StatFax”. The medicament FT 500 plus was prescribed in a dosage of 1 sachet – once a day from the 2nd or 3rd day of the cycle during 2 menstrual cycles (cycle in which sclerotherapy was performed and subsequent cycle) for 1 group. Vitamin D3 was prescribed in prophylactic doses of 2.000 IU to women who were not diagnosed with a deficiency of this vitamin and in medium therapeutic doses for hypovitaminosis during 2 menstrual cycles. The sclerotherapy procedure was performed in a sterile operating room on the 6th – 8th day of the menstrual cycle by transvaginal puncture of the cyst and aspiration of its contents under the control of transvaginal ultrasound, introduction into the cyst capsule 95 % ethanol solution. Women with endometriosis-associated infertility, who were prescribed pregravidary preparation with a complex vitamin medication with inositol and vitamin D3 and sclerotherapy had probably lower levels of AMH (by 12.90 %), progesterone (by 9.84 %) and probably higher levels of FSH (by 14.47 %), LH (by 21.14 %) estradiol (by 35.55 %) relative to the comparison group. At the same time, significantly lower indicators of FSH (by 21.98 %), LH (by 32.89 %) and estradiol (by 32.23 %) were found against their values before sclerotherapy. Performing of sclerotherapy with pregravidary preparation with a complex vitamin medication with inositol and vitamin D3 to women with endometriosis-associated infertility has a positive effect on the hormonal background.