bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of germline pathogenic variants in 22 cancer susceptibility genes in Swedish pediatric cancer patients
Authors: von Stedingk Kristoffer , Stjernfelt Karl-Johan , Kvist Anders , Wahlström Cecilia , Kristoffersson Ulf , Stenmark-Askmalm Marie , Wiebe Thomas , Hjorth Lars , Koster Jan , Olsson Håkan , Øra Ingrid 
Published: March 2021

AbstractUp to 10% of pediatric cancer patients harbor pathogenic germline variants in one or more cancer susceptibility genes. A recent study from the US reported pathogenic variants in 22 out of 60 analyzed autosomal dominant cancer susceptibility genes, implicating 8.5% of pediatric cancer patients. Here we aimed to assess the prevalence of germline pathogenic variants in these 22 genes in a population-based Swedish cohort and to compare the results to those described in other populations. We found pathogenic variants in 10 of the 22 genes covering 3.8% of these patients. The prevalence of TP53 mutations was significantly lower than described in previous studies, which can largely be attributed to differences in tumor diagnosis distributions across the three cohorts. Matched family history for relatives allowed assessment of familial cancer incidence, however, no significant difference in cancer incidence was found in families of children carrying pathogenic variants compared to those who did not.
Arabidopsis thaliana zinc accumulation in leaf trichomes is correlated with zinc concentration in leaves
Authors: Ricachenevsky Felipe K. , Punshon Tracy , Salt David E. , Fett Janette P. , Guerinot Mary Lou 
Published: March 2021

AbstractZinc (Zn) is a key micronutrient for plants and animals, and understanding Zn homeostasis in plants can improve both agriculture and human health. While root Zn transporters in plant model species have been characterized in detail, comparatively little is known about shoot processes controlling Zn concentrations and spatial distribution. Previous work showed that Zn hyperaccumulator species such as Arabidopsis halleri accumulate Zn and other metals in leaf trichomes. To date there is no systematic study regarding Zn accumulation in the trichomes of the non-accumulating, genetic model species A. thaliana. Here, we used Synchrotron X-Ray Fluorescence mapping to show that Zn accumulates at the base of trichomes of A. thaliana. Using transgenic and natural accessions of A thaliana that vary in bulk leaf Zn concentration, we demonstrate that higher leaf Zn increases total Zn found at the base of trichome cells. Our data indicates that Zn accumulation in trichomes is a function of the Zn status of the plant, and provides the basis for future studies on a genetically tractable plant species to understand the molecular steps involved in Zn spatial distribution in leaves.
Assessing the quality of water used for vegetable irrigation in Tamale Metropolis, Ghana
Authors: Abdallah Clement Kamil , Mourad Khaldoon A. 
Published: March 2021

AbstractThis paper assesses water quality that is used for vegetable irrigation in Tamale Metropolis, Ghana. A mixed-method of research design was employed in this study to collect and analyze the data based on survey instruments. The paper found that Escherichia coli (E. coli) that is usually used as an indicator of water contamination and heavy metals exist in all taken water samples. The mean concentrations of nutrients such as ammonia, nitrate, nitrite and phosphate were recorded as 0.022 mg/l to 5.98 mg/l for ammonia, 1.06 mg/l to 7.52 mg/l for nitrate, 0.031 mg/l to 0.056 mg/l for nitrate and 0.037 mg/l to 0.069 mg/l for phosphate. E. coli and Total Coliforms levels for Sanghani, Kamina and Waterworks from the laboratory analysis were recorded as 3.2 × 103 CFU 100 m/l and 5.5 × 102 CFU 100 m/l, 4.0 × 103 CFU 100 m/l and 1 × 102 CFU 100 m/l, and 2.1 × 103 CFU 100 m/l and 4.6 × 102 CFU 100 m/l respectively. To conclude, based on the measured parameters, water used for irrigation in the Tamale Metropolitan is polluted and may cause potential health risks. Therefore, farmers, traders and consumers need to apply further safety measures to make the vegetables safe.
Splitting sleep between the night and a daytime nap reduces homeostatic sleep pressure and enhances long-term memory
Authors: Cousins James N. , Leong Ruth L. F. , Jamaluddin S. Azrin , Ng Alyssa S. C. , Ong Ju Lynn , Chee Michael W. L. 
Published: March 2021

AbstractDaytime naps have been linked with enhanced memory encoding and consolidation. It remains unclear how a daily napping schedule impacts learning throughout the day, and whether these effects are the same for well-rested and sleep restricted individuals. We compared memory in 112 adolescents who underwent two simulated school weeks containing 8 or 6.5 h sleep opportunities each day. Sleep episodes were nocturnal or split between nocturnal sleep and a 90-min afternoon nap, creating four experimental groups: 8 h-continuous, 8 h-split, 6.5 h-continuous and 6.5 h-split. Declarative memory was assessed with picture encoding and an educationally realistic factual knowledge task. Splitting sleep significantly enhanced afternoon picture encoding and factual knowledge under both 6.5 h and 8 h durations. Splitting sleep also significantly reduced slow-wave energy during nocturnal sleep, suggesting lower homeostatic sleep pressure during the day. There was no negative impact of the split sleep schedule on morning performance, despite a reduction in nocturnal sleep. These findings suggest that naps could be incorporated into a daily sleep schedule that provides sufficient sleep and benefits learning.
Application of 3D printed model for planning the endoscopic endonasal transsphenoidal surgery
Authors: Huang Xing , Fan Ni , Wang Hai-jun , Zhou Yan , Li Xudong , Jiang Xiao-Bing 
Published: March 2021

AbstractThe application of 3D printing in planning endoscopic endonasal transsphenoidal surgery is illustrated based on the analysis of patients with intracranial skull base diseases who received treatment in our department. Cranial computed tomography/magnetic resonance imaging data are attained preoperatively, and three-dimensional reconstruction is performed using MIMICS (Materialise, Leuven, Belgium). Models of intracranial skull base diseases are printed using a 3D printer before surgery. The models clearly demonstrate the morphologies of the intracranial skull base diseases and the spatial relationship with adjacent large vessels and bones. The printing time of each model is 12.52–15.32 h, and the cost ranges from 900 to 1500 RMB. The operative approach was planned in vitro, and patients recovered postoperatively well without severe complications or death. In a questionnaire about the application of 3D printing, experienced neurosurgeons achieved scores of 7.8–8.8 out of 10, while unexperienced neurosurgeons achieved scores of 9.2–9.8. Resection of intracranial skull base lesions is demonstrated to be well assisted by 3D printing technique, which has great potential in disclosing adjacent anatomical relationships and providing the required help to clinical doctors in preoperative planning.
Validity and reliability of the ‘Isometric Exercise Scale’ (IES) for measuring ratings of perceived exertion during continuous isometric exercise
Authors: Lea John W. D. , O’Driscoll Jamie M. , Coleman Damian A. , Wiles Jonathan D. 
Published: March 2021

AbstractIsometric exercise (IE) interventions are an effective non-medical method of reducing arterial blood pressure (BP). Current methods of prescribing and controlling isometric exercise intensity often require the use of expensive equipment and specialist knowledge. However, ratings of perceived exertion (RPE) may provide a more accessible means of monitoring exercise intensity. Therefore, the aim of this study was to assess the validity of a specific Isometric Exercise Scale (IES) during a continuous incremental IE test. Twenty-nine male participants completed four incremental isometric wall squat tests. Each test consisted of five 2-min stages of progressively increasing workload. Workload was determined by knee joint angle from 135° to 95°. The tests were continuous with no rest periods between the stages. Throughout the exercise protocol, RPE (IES and Borg’s CR-10), heart rate and blood pressure were recorded. A strong positive linear relationship was found between the IES and the CR-10 (r = 0.967). Likewise, strong positive relationships between the IES and wall squat duration (r = 0.849), HR (r = 0.819) and BP (r = 0.841) were seen. Intra-class correlation coefficients and coefficients of variations for the IES ranged from r = 0.81 to 0.91 and 4.5–54%, respectively, with greater reliability seen at the higher workloads. The IES provides valid and reliable measurements of RPE, exercise intensity, and the changes in physiological measures of exertion during continuous incremental IE; as such, the IES can be used as an accessible measure of exercise intensity during IE interventions.
Macular irregularities of optical coherence tomographic vertical cross sectional images in school age children
Authors: Yamashita Takehiro , Terasaki Hiroto , Asaoka Ryo , Yoshihara Naoya , Kakiuchi Naoko , Sakamoto Taiji 
Published: March 2021

AbstractThe purpose of this study was to compare the incidences of macular irregularities of elementary school (ES) and junior high school (JHS) students. This was a prospective cross-sectional observational study of 122 right eyes of 122 ES students (8–9 years) and 173 right eyes of 173 JHS students (12–13 years). Vertical cross-sectional images of the macula were obtained by optical coherence tomography. The eyes were classified based on the vertical symmetry of the posterior pole, and then sub-classified as convex-, flat-, concave-, or dome-shaped based on the direction of the curvature of the retinal pigment epithelium. One hundred and two eyes (83.6%) were placed in the symmetrical group in the ES students and 149 eyes (86.1%) in the JHS students. Twenty eyes (16.4%) were placed in the asymmetric groups in the ES students and 24 eyes (13.9%) in the JHS students. In symmetrical group, 78 and 118 eyes had a convex-shape (76.4 and 79.2%), followed by 22 and 29 eyes of dome-shaped group (21.6 and 19.4%) in ES and JHS students respectively. Because the incidences of the posterior pole shapes were not significantly different between the groups, it is likely that the macular irregularities develop before the age of ES.
The Transformation of Security Concepts
Authors: Schroeder Ursula 
Published: March 2021

Abstract
This chapter examines the shift of security concepts away from the traditional focus on war and the State in a Westphalian international system, discussing the evolution of current security concepts in their historical and theoretical context. It shows how State-based security concepts have slowly made way for broader understandings of security over the past decades. Security is no longer seen exclusively as a matter of the State; violent conflicts are more often than not intra-State or internationalized in nature and collective security arrangements have not always been effective in crisis situations. The chapter then argues that the successive broadening and deepening of security concepts has led to issues of coherence (and lack thereof) and concept stretching in the research field, while leaving crucial dynamics of contemporary security governance underexplored. It highlights several challenges posed by the ongoing and rapid transformation of global security dynamics and discusses their implications for international law.
Global Security and Neurophilosophy
Authors: Al-Rodhan Nayef , Puscas Ioana-Maria 
Published: March 2021

Abstract
This chapter evaluates the fundamental starting point in political theory: human nature. In doing so, it goes beyond conventional wisdom in International Relations. To understand conflict and to chart a way forward, we must re-examine our understanding of human nature. The two dominant theories of International Relations, Realism and Idealism/Internationalism, derived their intellectual origins from such contrasting and dichotomous views of human nature. One, exemplified by Thomas Hobbes, was pessimistic both about human nature and States. The other, exemplified by Immanuel Kant and to some extent Jean-Jacques Rousseau, believed in an innate perfectibility of humans, of States and the international society, which would evolve towards peace. Today, a growing body of evidence from neuroscience permits the re-examination of long-held claims about human nature and what it is that truly drives and motivates human behaviour. Neurophilosophy, the interdisciplinary field connecting findings from neuroscience and philosophy, is relevant for global security and for understanding what can propel good governance, peace, and security.
Terrorism and the Security Council
Authors: Duffy Helen , van den Herik Larissa 
Published: March 2021

Abstract
This chapter details the United Nations Security Council’s (UNSC) intense regulatory approach to counter-terrorism and its consequences, including the direct and indirect repercussions for affected individuals, and the broader global security landscape. The main argument is that the expansion of the UNSC’s role has gradually opened up a space of indeterminacy and unaccountability. Two dimensions are explored here: (i) the creation of a quasi-permanent counter-terrorism sanctions regime under Chapter VII and (ii) the Council’s ever-expanding ‘legislative’ activities, amongst others in relation to ‘foreign terrorist fighters’ and incitement or provocation. The chapter exposes underlying tendencies and ulterior effects of the UNSC’s approach, including the expansive reach of undefined or ill-defined phenomena, a reflex of over-criminalization, and the increasing involvement of the private sector, including financial institutions, in the counter-terrorism sphere. The impact on human rights, participatory democracy, the shrinking space for civil society, humanitarian assistance and peacebuilders, accountability, and rule of law is profound. Ultimately, the chapter tells a story of uncertain threats and unaccountable actors in counter-terrorism practice and the adverse effects on security in the long run.
Aggression
Authors: Kreß Claus 
Published: March 2021

Abstract
This chapter discusses the concept of aggression. Article 39, the opening clause of the United Nations Charter’s collective security system, contains the term ‘act of aggression’, the existence of which in a given case falls to be determined by the United Nations (UN) Security Council. Recalling Article 39, the UN General Assembly, in 1974, adopted a resolution on the Definition of Aggression (Resolution 3314 (XXIX)). As the term ‘act of aggression’ is used alongside the terms ‘threat to peace’ and ‘breach of the peace’ in Article 39, the UN Security Council is not bound to determine the existence of an act of aggression to activate the Charter&apos;s collective security system and authorize the use of force by one or more States in order to maintain or restore international peace and security. In the view of the International Court of Justice and the International Law Commission, the prohibition of aggression forms part of customary international law. Here again, however, the distinct legal significance of the concept compared to ‘use of force’ and ‘armed attack’ is of quite limited reach. Contrariwise, the concept of aggression has been of considerable importance in the realm of international criminal law since the latter’s inception.
Climate Change and Security
Authors: Gupta Joyeeta , Bosch Hilmer 
Published: March 2021

Abstract
This chapter describes the relationship between climate change and security. Successive reports of the Intergovernmental Panel on Climate Change have provided growing evidence of the impacts of climate change. Climate change can affect human well-being in terms of access to water, food, energy, and land, as well as in terms of risks to human health. Thus, climate change is seen as a driver of other socio-ecological problems worldwide. Climate change is also seen as a risk and threat multiplier, as it can exacerbate existing challenges faced by States, including poor governance institutions and poverty. However, climate change policy could potentially be a ‘threat minimizer’ if mitigation and adaptation measures are integrated into the development paradigm. Against this background, the chapter addresses the following issue: What is the nature of the security debate raised by the climate change issue and how is this being addressed within scholarly, policy, and legal fora? It looks at the different ways in which security has been defined in the literature and its diverse implications for law and policy.
We Who Are Not as Others
Authors: Tzanakopoulos Antonios 
Published: March 2021

Abstract
This chapter assesses sanctions as a (global) security governance tool. Law is an obvious tool for ‘security governance’, and ‘sanctions’ are an inextricable element of law. The chapter begins by discussing the meaning of sanctions and (global) security. It then traces the historical trajectory in the use of collective and unilateral sanctions in the service of security. It argues that global security is nothing but national security projected onto the international plane. When a hegemonic concept of security—that is to say, of the existential threats ‘we’ need to protect against—is imposed and accepted, and for as long as it is accepted, collective sanctions rule supreme and can be particularly effective. When there is fragmentation and antagonism as to what the threats are, when there is no hegemonic national security accepted as synonymous to international security, there is a return to unilateral sanctions and a concomitant sidelining of collective security mechanisms.
Supplemental Intraoperative Oxygen and Long-term Mortality: Subanalysis of a Multiple Crossover Cluster Trial
Authors: Jiang Qiliang , Kurz Andrea , Zhang Xiaobao , Liu Liu , Yang Dongsheng , Sessler Daniel I. 
Published: March 2021

Background
Whether supplemental oxygen worsens long-term mortality remains unclear, with contradictory trial results. The authors therefore tested the hypothesis that supplemental oxygen (80% vs. 30%) increases the hazard for long-term mortality.

Methods
The authors conducted a post hoc analysis of a large multiple crossover cluster trial in which more than 5,000 colorectal surgeries on 4,088 adults were allocated to receive either 30% or 80% inspired oxygen during general anesthesia. The authors assessed the effect of 80% versus 30% target-inspired oxygen on long-term mortality and calculated Kaplan–Meier survival estimates. Analysis was restricted to patients with a home address in Ohio because the authors could obtain reliable vital status information from the Ohio Department of Health (Columbus, Ohio) for them.

Results
A total of 3,471 qualifying colorectal surgeries performed in 2,801 patients were analyzed, including 1,753 (51%) surgeries in 1,577 patients given 80% oxygen and 1,718 surgeries in 1,551 patients given 30% oxygen. The observed incidence of death after a median of 3 yr was 13% (234 of 1,753) in the 80% oxygen group and 14% (245 of 1,718) in the 30% oxygen group. The estimated hazard ratio for mortality was 0.94 (95% CI, 0.78 to 1.13; P = 0.493).

Conclusions
In this post hoc analysis of a large, controlled trial, supplemental oxygen did not increase postoperative mortality.

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Comparison of Trauma Severity Scores (ISS, NISS, RTS, BIG Score, and TRISS) in Multiple Trauma Patients
Authors: Höke Mehmet Hilmi , Usul Eren , Özkan Seda 
Published: March 2021

Background:
Trauma severity scoring systems are routinely used to monitor trauma patient outcomes. Yet, the most accurate scoring system remains an elusive target.

Objective:
We aim to compare trauma severity scales (ISS, NISS, RTS, TRISS, and BIG) in multitrauma patients and investigate BIG as one of the new trauma severity scoring systems.

Methods:
The demographic data of the patients, vital signs, injury mechanisms, body regions exposed to trauma, final diagnosis, the injury severity scales—Injury Severity Score (ISS), New Injury Severity Score (NISS), Revised Trauma Score (RTS), base deficit, international normalized ratio, and Glasgow Coma Scale (BIG), and Trauma and Injury Severity Score (TRISS)—the length of stay in hospital, and the progress of the patients were examined.

Results:
A total of 426 cases were included in the study. The best performing score in determining mortality was TRISS (area under the curve [AUC]: 0.93, sensitivity 97.1% and specificity 76.7%). This was followed by the NISS, BIG, ISS, and RTS, respectively. For the prediction of intensive care unit admission, the NISS was the most successful with an AUC value of 0.81. There was a significant relationship in terms of the length of stay in all trauma scores (p < .05).

Conclusions:
The most successful score in predicting mortality in trauma patients was the TRISS, whereas the NISS was the most successful in predicting intensive care unit admission. The newly developed BIG score can be used as a strong scoring method for predicting prognosis in trauma patients.
Biomechanical analysis of the closed reduction internal fixation with cannulated screw of femoral neck fractures
Authors: Wang Jian-Guang , Wu Jun-Xian , Li Yu-Min , Xu You-Yin 
Published: March 2021

Abstract
The influencing factors in closed reduction internal fixation with cannulated screw of femoral neck fractures have not been well investigated. This study evaluated these factors in patients with femoral neck fractures.
Fifty-seven patients (36 males and 21 females) diagnosed with femoral neck fracture with the average age of 52.44 ± 15.04 years who underwent closed reduction internal fixation with cannulated screw were included in this study. Data were collected through case report reviews, phone call follow-ups, and outpatient follow-ups to evaluate pre- and postoperative radiograph images. Statistical analysis was performed using Garden classification, binary and multinomial logistic regression analysis by including factors such as patient's age, gender, fracture type, time to fixation, reduction quality, functional recovery period, removal of cannulated screw, and preoperative traction. Logistic regression analysis revealed that age and reduction quality was statistically significant (P < .05) to clinical outcome and other factors were not statistically significant.
The main factors affecting clinical outcomes were functional recovery and reduction quality. The biomechanical effects of fixation provide a good foundation for fracture healing. Patient's conditions should be carefully evaluated before selecting reduction procedures to reach an optimal surgical outcome.