bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical relevance of glomerular IgM deposition in patients with lupus nephritis
Authors: Wang Fengmei , Yu Jirong , zhang Lei , Zhang Yan , Zhang Jie , Liu Bicheng , Yang Xiaowei 
Published: March 2021

Abstract
Background
The aim of the study was to investigate the clinical relevance of IgM deposition in patients with LN in a large cohort.
Results
217 patients with renal biopsy–proven lupus nephritis were enrolled. The associations between glomerular IgM deposition and clinicopathological parameters were further analyzed. IgM deposition was positively correlated with glomerular C1q and C3 deposition moderately (r = 0.436, P < 0.001; r = 0.408, P < 0.001, respectively), and inversely correlated with plasma levels of C3 and CFH mildly (r=-0.138, P = 0.043; r=-0.147, P = 0.037, respectively). By multivariate analysis, we found that glomerular IgM deposition independently contributes to glomerular C3 deposition in patients with lupus nephritis (OR = 2.002, 95% CI: 1.295–3.094, P = 0.002). In addition, we also found that patients with IgM 0+-2 + had similar plasma CFH levels, but in patients with IgM3+-4+, plasma CFH levels were significantly lower (300.4 ± 155.8µg/ml vs. 429.9 ± 187.5µg/ml, P < 0.001). Furthermore, patients with high density of glomerular IgM and low levels of CFH had heavier proteinuria, higher serum creatinine and lower plasma C3 levels (5.7 ± 3.1g/d vs. 4.7 ± 3.5g/d, P = 0.037;150.1 ± 121.0µmol/L vs. 105.6 ± 97.1µmol/L, P = 0.005; 0.3 ± 0.2µg/L vs. 0.4 ± 0.2µg/L, P = 0.04, respectively), comparing with those with low density of glomerular IgM and low levels of CFH.
Conclusions

Our results suggested IgM might bind to
injury-associated epitopes and be involved in disease progression
and provided a possible relevance of CFH and IgM in the process of
alternative pathway (AP) activation.
Total Magnetic Resonance Imaging of Cerebral Small Vessel Disease Burden Predicts Dysphagia in Patients with a Single Recent Small Subcortical Infarct
Authors: Zhang Lulu , Tang Xiang , Li Yidan , Zhu Juehua , Ding Dongxue , Zhou Yun , Diao Shanshan , Kong Yan , Cai Xiuying , Yao Ye , Fang Qi 
Published: March 2021

Abstract
Background
The study was performed to identify the association between total magnetic resonance imaging burden of small vessel disease and occurrence of post-stroke dysphagia in patients with a single recent small subcortical infarct.
Methods
All patients with a magnetic resonance imaging-confirmed single recent small subcortical infarct underwent the water-swallowing test and volume-viscosity swallow test within the first 24 hours following admission to assess swallowing. Demographic and clinical data were extracted from our stroke database. Based on brain magnetic resonance imaging, we independently rated the presence of cerebral microbleeds, lacunes, white matter hyperintensities and enlarged perivascular spaces. The presence of each small vessel disease feature was summed in the total small vessel disease burden, ranging from 0–4.
Results
In total, 308 patients with a single recent small subcortical infarct were enrolled. Overall, 54 (17.5%) were diagnosed with post-stroke dysphagia. The risk factors related to post-stroke dysphagia included the following: older age, National Institute of Health Stroke Scale, higher C-reactive protein levels and higher fibrinogen levels. Based on multiple logistic regression, two variables with the most significant associations, namely, National Institute of Health Stroke Scale and total small vessel disease burden, were combined with age, gender, history of hypertension, C-reactive protein level and fibrinogen level.
Conclusions
Dysphagia in patients with a single recent small subcortical infarct resulted from severe small vascular disease, which was associated with systemic inflammation. This information might provide a new anti-inflammatory treatment for post-stroke dysphagia in the future.
Sublingual Immunotherapy Tablet – a Cost-minimizing Alternative in the Treatment of Tree Pollen-induced Seasonal Allergic Rhinitis in Canada
Authors: Ellis Anne K. , Gagnon Rémi , Hammerby Eva , Shen Julia , Gosain Sheena 
Published: March 2021

Abstract
Background: A cost-minimization analysis (CMA) was performed to evaluate the economic implications of introducing the SQ Tree sublingual immunotherapy (SLIT)-tablets marketed as ITULATEK® (Health Canada regulatory approval in April 2020) for the treatment of pollen-induced (birch, alder and/or hazel) seasonal allergic rhinitis in Canada (Ontario and Quebec), where Tree Pollen subcutaneous immunotherapy (SCIT) is already an available treatment option.Methods: A CMA was deemed appropriate and was based on the assumption that the SQ Tree SLIT-tablets have comparable efficacy to Tree Pollen SCIT. A societal perspective was adopted in the model, including relevant costs of medications, costs of health care services, and productivity losses. The time horizon in the model was three years, which corresponds to a minimal treatment course of allergy immunotherapy. Resource use and costs were based on published sources, where available, and validated by Canadian specialist clinicians (allergists) in active practice in Ontario and in Quebec, where applicable. A discount rate of 1.5% was applied in accordance with the Canadian Agency for Drugs and Technologies in Health (CADTH) guidelines. To assess the robustness of the results, scenario analyses were performed by testing alternative assumptions for selected parameters (e.g., Tree Pollen SCIT resource use, discount rates, number of injections, annual SCIT dosing with maintenance injections, and nurse time support), to evaluate their impact on the results of the analysis.Results: The direct costs, including the drug costs, physician and nursing services costs, for three years of treatment, were similar for both SQ Tree SLIT-tablets vs. Tree Pollen SCIT in both Ontario and Quebec ($2,799.01 and $2,838.70 vs. $2,813.41 and $2771.81, respectively). However, when the indirect costs (including patient’s travel expenses and lost working hours) are included in the model, total savings for the treatment with SQ Tree SLIT-tablets of $1,691.44 for Ontario and $1,705.63 for Quebec were observed. Scenario analyses were conducted and showed that changes in assumptions continue to result in the savings of SQ Tree SLIT- tablets over Tree Pollen SCIT. Conclusions: The CMA indicates that SQ Tree SLIT-tablets are a cost-minimizing alternative to Tree Pollen SCIT when considered from a societal perspective in Ontario and Quebec.
Effect of arbuscular mycorrhizal fungi (AMF) and plant growth-promoting rhizobacteria (PGPR) on microbial community composition of phenanthrene and pyrene contaminated soils using Illumina HiSeq sequencing
Authors: Li Wei , Li Wenbin , Xing Lijun , Guo Shaoxia 
Published: March 2021

Abstract
In order to determine the influence of arbuscular mycorrhizal fungi (AMF, Glomus versiforme) and plant growth-promoting rhizobacteria (PGPR, Pseudomonas fluorescens, Ps2-6) on degradation of phenanthrene (PHE) and pyrene (PYR) and the change of microbial community composition in soils planted with tall fescue (Festuca elata), four treatments were set up in phenanthrene (PHE) and pyrene (PYR) contaminated soil: tall fescue (CK), AMF + tall fescue (GV), PGPR + tall fescue (PS), and AMF + PGPR + tall fescue (GVPS). Our results showed that the highest removal percentage of PHE and PYR in contaminated soil as well as biomass of tall fescue were observed in GVPS. PHE and PYR accumulation by tall fescue roots were higher than shoots, the mycorrhizal status was best manifested in the roots of tall fescue inoculated with GVPS, and GVPS significantly increased the number of PGPR proliferation in tall fescue rhizosphere soil. Paired-end Illumina HiSeq analysis of the 16S rRNA gene and Internal Transcribed Spacer (ITS) region sequences was used to assess changes in the bacterial and fungal communities composition of the four treatments. GVPS positively affected the species and abundance of bacteria and fungi in PHE and PYR contaminated soil, an average of 71,144 high quality bacterial 16S rDNA tags and 102,455 ITS tags were obtained in GVPS, and all of them were assigned to 6,327 and 825 operational taxonomic units (OTUs) at a 97% similarity, respectively. Sequence analysis revealed that Proteobacteria was the dominant bacterial phylum, Ascomycota was the dominant fungal phylum in all treatments, whereas Proteobacteria and Glomeromycota were the most prevalent bacterial and fungal phyla in GVPS, respectively. And in the generic level, Planctomyces and Meyerozyma were the richest bacterial and fungal genus in all treatments, respectively, whereas Sphingomonas and Fusarium were the dominant bacterial and fungi genus in GVPS. Overall, our findings revealed that application of Glomus versiforme and Pseudomonas fluorescens, Ps2-6 had an effective role in improving the growth characteristics, root infection of F. elata and soil microbial community composition in PHE and PYR contaminated soils, but no obvious in degradation efficiencies of PHE and PYR as compared to the control.
Antinuclear antibodies (ANA) in COVID-19 infection
Authors: Yumuk Zeki , Okumuş Elif 
Published: March 2021

Abstract
We examined correlates of antinuclear antibody (ANA) positivity in individuals with COVID-19 infection. Sera from 156 patients were evaluated by indirect immunofluorescence on Hep-2 cells for ANA pattern and semi-quantitative titer. There was a significant difference in the prevalence of ANA (1:100) by gender (P = 0.0294). Male gender was correlated with ANA positivity and association persisted in multivariable analyses (OR = 0.354; CI: 0.139–0.816; P = 0.0200). Age (OR = 1.932; CI: 0.929–4.121; P = 0.0814), warm weather (OR = 1.307; CI: 0.611–2.921; p = 0.4989), geographic location (or = 0.886; CI:0.353–2.442; P = 0.8042), and diabetes mellitus (OR = 1.765; CI:0.513–5.477; P = 0.3369) were not correlated with ANA positivity. In this analysis, hospitalization was used as indicator for a more severe course. Of the 156 COVID-19 patients, 18 (11.5%) were hospitalized. Among 18 hospitalized patients, 4 (22.2%) were ANA positive (Table 2), although this did not reach statistical significance (OR = 0.841; CI: 0.227–2.527; p = 0.7725). In conclusion, although males were more prone to produce ANA during COVID-19 infection, this was not correlated with severe course.
Effect of 6 Weeks Aerobic Training with Nanocurcumin Consumption on IL1β, Nitric Oxide and Depression in Women with Syndrome Metabolic
Authors: Osali Ali , Rostami Alireza 
Published: March 2021

Abstract
Backgrounds and Objectives: The use of anti-inflammatory supplements is important in improving the function of obese people. The aim of this research was to investigate the effect of 6 weeks aerobic exercise with moderate intensity and consumption of nanocurcumin on IL1β, nitric oxide and depression in 60-65 years old women with syndrome metabolic. Materials and Methods: 44 women with metabolic syndrome (MetS) were randomly selected and divided into four groups of 10, including of MetS exercise+ Curcumin (MECU), MetS exercise (ME), MetS NanoCurcumin (MCU), MetS control (MC Training groups performed an exercise protocol of aerobic exercise for 6 weeks (three sessions per week). Blood samples were obtained before and after training period for antioxidant indicators and lipid degradation measurement. Also, Beck anxiety questionnaire used for evaluating levels of anxiety. T-test and one-way analysis of variance were used for the evaluation of within-group and between-group differences, respectively.Results: There was a significant difference in IL1β, NO and depression before and after exercise in all three experimental groups (p≤0.05). Also, the results showed a significant difference in the level of depression, NO and depression in the Reaserch groups. The highest decrease in these variables was observed in the aerobic training group and training with nanocurcumin consumption group (p≤0.05).Conclusion: These findings indicated that six-week nanocurcumin supplementation with aerobic training a suitable method for reducing IL1β and NO and depression preventing metabolic, cardiovascular and inflammatory diseases in women with syndrome metabolic.Name of the registry: IR.SEMUMS.REC.1396.107Trial registration number: IRCT2017082335857N1
Sexual Function in Women With and Without Female Genital Mutilation in Reproductive Age in South of Iran
Authors: Bokaie Mahshid , Hatefi Samaneh , Mojahed Shahnaz , Roozbeh Nasibeh 
Published: March 2021

Abstract
Objectives: Female genital mutilation (FGM) is an important public health issue, especially in developing countries and it is still done in some parts of Iran. This study aimed to investigate the effect of FGM on the sexual function of women of reproductive age in Hormozgan province/IRAN.Study design: This study is a descriptive-analytical case-control study that was conducted in 2020 on 209 married women of reproductive age (15-49) in rural areas of Minab and Sirik counties in Hormozgan province/IRAN. Main outcome measures: The reliable and valid questionnaire FSFI for assessing female sexual function in the two groups was used after to obtain informed and voluntary consent from all participants and data with SPSS v: 16 software and with using descriptive/ Analytical statistics tests with a significant level of 0.05 were examined. Results: There is a significant difference between mutilated and non-mutilated women in the total score of sexual function(22.18±3.23 versus 23.41±2.52 respectively, p=0.023) and the domains of lubrication(3.04±0.62 versus 3.3±0.53 respectively, P=0.000), orgasm(3.81±0.63 versus 4.08±0.47 respectively, P=0.003), and sexual satisfaction(5.09±0.1 versus 5.37±0.87 respectively, P=0.017) But in the domains of desire, arousal, and pain in the two groups was no significant difference(P-value>0.05). Conclusion: FGM maybe leads to sexual dysfunction. Although most women were reluctant to perform mutilation on their daughters, more educational Actions are suggested to educate women about the impact of female mutilation on their sexual function. Counseling programs are also recommended to improve the sexual function of mutilated women.
Human electrocorticography reveals a common neurocognitive pathway for mentalizing about the self and others
Authors: Tan Kevin , Daitch Amy , Pinheiro-Chagas Pedro , Fox Kieran , Parvizi Josef , Lieberman Matthew 
Published: March 2021

Abstract
Hundreds of neuroimaging studies show that mentalizing (i.e., theory of mind) recruits default mode network (DMN) regions with remarkable consistency. Nevertheless, the social-cognitive functions of individual DMN regions remain unclear, perhaps due to the limited spatiotemporal resolution of neuroimaging. We used electrocorticography (ECoG) to record neuronal population activity while 16 human subjects judged the psychological traits of themselves and others. Self- and other-mentalizing recruited near-identical neuronal populations in a common spatiotemporal sequence: activations were earliest in visual cortex, followed by temporoparietal DMN regions, and finally medial prefrontal cortex. Critically, regions with later activations showed greater functional specificity for mentalizing, greater self/other differentiation, and stronger associations with behavioral response times. Moreover, other-mentalizing evoked slower and lengthier activations than self-mentalizing across successive DMN regions, suggesting temporally extended demands on higher-level processes. Our results reveal a common neurocognitive pathway for self- and other-mentalizing that follows a hierarchy of functional specialization across DMN regions.
Which Factors Are Predicting the Mortality in Patients With Covid 19 in the Intensive Care Unit?
Authors: Parpucu Murat , Turan Sema , Dal Hayriye Cankar , Tosun Damla , Yalnız Kudret Yasemin , Kazancı Dilek 
Published: March 2021

Abstract
Background: COVID 19 infection is a global health problem; clinical and laboratory parameters have been developed to predict this disease-related mortality/morbidity. Some of these parameters are clinical parameters, while some are laboratory parameters. This study aims to determine whether APACHE II, GCS, age, presence of comorbidity, and absolute lymphocyte count effectively predict mortality in patients admitted to intensive care due to COVID 19.Method: We have included 108 PCR-positive COVID 19 patients admitted to the intensive care between 1 October and 31 November 2020 in our research. Demographic characteristics of all patients, APACHE II values within the first 24 hours of admission to intensive care, the Glasgow Coma Scale, the presence of comorbidity, lymphocyte count during intensive care admission, duration of intensive care stay, and the mortality rates were recorded.Results: The average age of 108 individuals evaluated in the study was 67 ± 13.61 years, and 56.5% of the patient group consisted of the geriatric age range. Seventy (64.8%) of the patients were female, eighty-nine (82.4%) patients had at least one comorbidity. In the multivariate analysis, it was determined that lymphocyte value, APACHE II score, and the presence of any comorbidity are independent prognostic factors for mortality when accepted to ICU.Conclusion: In our study, we have determined that age, APACHE II value, presence of comorbidity, and baseline lymphocyte counts are independent predictors of mortality.Trial Registry: SEMA TURAN-2021-01-13T10_31_59Registry address:https://bilimselarastirma.saglik.gov.tr
Molecular analysis of goose parvovirus field strains from the Derzsy’s disease outbreak revealed the local European-associated variants
Authors: Isidan Hakan , Turan Turhan , ATASOY Mustafa Ozan , Coskun Alparslan 
Published: March 2021

Abstract
Since the first recognition in the early '60s, Derzsy’s disease has occasioned significant economic losses in the goose meat industry through the world. Today, Derzsy’s disease still maintains its importance for small-scale waterfowl farming, despite not having a remarkable impact on public health. In the present study, we investigated the distribution of goose parvovirus (GPV) strains and its potential variants from the 2019 outbreak in Turkey. The tissue samples were obtained from the infected eggs and the goslings, which were raised in the distinct farming areas of the various provinces. For this purpose, a novel primer set which amplifies the 630 bp of VP3 region was designed to confirm the GPV infection by conventional PCR method. After the diagnosis, 4709 base nucleotide data including structural, non-structural and 5' inverted terminal repeat regions were obtained from the three samples in the Middle Anatolian region. The multiple comparison and phylogenetic analyses together demonstrated that the field strains clustered with European group 2 and presented a series of unique amino acid substitutions which could determine the virulence. These results confirmed the European-related field strains caused the outbreak in minor Asia, which could assist to understand the GPV circulation between Asia and Europe.
Single cell transcriptomic profiling of neurodegeneration mediated by tau propagation in a novel 3D neuron-astrocyte coculture model
Authors: Rickner Hannah , Jiang Lulu , Hong Rui , O'Neill Nicholas K. , Wolozin Benjamin , Cheng Christine 
Published: March 2021

Abstract
Research into neurodegeneration has been hampered by lack of systems that accurately recapitulate neurodegenerative processes1. Propagation of tau through a ‘prion-like’ process has emerged as an important aspect of neurodegenerative diseases including Alzheimer’s disease2. However, molecular mechanism of tau propagation is still largely unknown and a human 3D cellular model is still lacking. Here, we report development of the AstAD system, which uses human iPSCs to create neuron-astrocyte spheroids that incorporates propagation of toxic tau oligomers3,4. Single cell transcriptomic profiling reveals roles for ribosomes, TNF mediated neuroinflammation and heat shock proteins (HSP) as major elements of the disease stress response. Treatment with the HSP90 inhibitor PU-H71, which is selective for the dysfunctional HSP epichaperome, demonstrates reduction of pathology and neurodegeneration in the AstAD system5.*Hannah Drew Rickner & Lulu Jiang contributed equally.
Using concept mapping to prioritize barriers to diabetes care and self-management for those who experience homelessness
Authors: Grewal Eshleen K , Campbell Rachel B , Booth Gillian L , McBrien Kerry A , Hwang Stephen W , O'Campo Patricia , Campbell David J. T. 
Published: March 2021

Abstract
Background
Diabetes is a chronic medical condition which demands that patients engage in self-management to achieve optimal glycemic control and avoid severe complications. Individuals who have diabetes and are experiencing homelessness are more likely to have poor glycemic control and adverse outcomes. Our objective was to collaborate with individuals living with homelessness to better understand the barriers they face in managing diabetes, as a first step in identifying solutions for enhancing diabetes management in this population.
Methods
We recruited individuals with lived experience of homelessness and diabetes (i.e. clients; n = 32) from Toronto and health and social care providers working in the areas of diabetes and/or homelessness (n = 27) from across Canada.
We used concept mapping, a
participatory research method, to engage participants in
brainstorming barriers to diabetes management, which were
subsequently categorized into clusters and rated based on their
impact on diabetes management.
The ratings were also standardized for
each participant group, organized according to the clients’ cluster
structure, and those clusters were compared using t-tests.
The Concept Systems Global MAX software was utilized to generate cluster maps.
Results
The brainstorming identified 43 barriers to diabetes management. The clients’ map featured 9 clusters of barriers: Challenges to getting healthy food, Inadequate income, Navigating services, Not having a place of your own, Relationships with professionals, Diabetes education, Emotional wellbeing, Competing priorities, and Weather-related issues. The providers’ map had 7 clusters: Access to healthy food, Dietary choices in the context of homelessness, Limited finances, Lack of stable, private housing, Navigating the health and social sectors, Emotional distress and competing priorities, and Mental health and addictions. The highest rated clusters were Challenges to getting healthy food (clients) and Mental health and addictions (providers). After standardizing, Challenges to getting healthy food was rated higher by the clients (p = 0.01) and Competing priorities (p = 0.03) was rated higher by the providers.
Conclusions
Experiencing homelessness poses numerous barriers to managing diabetes, the greatest of which according to clients, is Challenges to getting healthy food. This study showed that the way clients and providers perceive these barriers differs considerably, which highlights the importance of including clients’ insights when assessing needs and designing effective solutions.