bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sistem Pakar Mendiagnosis Penyakit Pada Tanaman Mentimun menggunakan Metode Dempster Shafer Berbasis Android
Authors: Amri Syaiful , Siahaan R. Fanri 
Published: June 2021

Abstrak— Teknologi informasi hampir tidak dapat dilepaskan dari berbagai aspek kehidupan manusia, dikarenakan kemudahan untuk mengakses informasi adalah salah satu pemanfaatannya. Minimnya pakar tumbuhan dan pengetahuan petani dalam menangani penyakit pada tanaman mentimun menyebabkan kerugian bagi petani khususnya petani mentimun. Selain daripada itu hal ini juga menjadi hambatan bagi para petani mentimun untuk mendiagnosa dan melakukan penanganan yang tepat terhadap penyakit mentimun yang menyerang tanaman yang mereka tanam. Petani kurang paham terhadap jenis penyakit pada tanaman mentimun, sehingga lambatnya proses penanganan pada tanaman mentimun. Dempster-Shafer dikenal adanya Frame of Discrement yang dinotasikan dengan dengan θ. Frame ini merupakan semesta pembicaraan dari sekumpulan hipotesis.Sistem pakar umumnya didefinisikan sebagai sebuah sistem yang dirancang untuk memodelkan kemampuan menyelesaikan masalah seperti layaknya seorang pakar (human expert). Identifikasi masalah dalam penelitian ini yaitu kerusakan pada tanaman mentimun akibat sulitnya mengidentifikasi penyakit pada tanaman mentimun. ruang lingkup/batasan masalah dalam penelitian ini Data penyakit yang akan diteliti sebanyak 6 penyakit, data gejala yang akan diteliti sebanyak 12 gejala. Metode yang digunakan dalam mendiagnose penyakit pada tanaman mentimun ialah metode Dempster Shafer. Aplikasi yang digunakan adalah aplikasi Adobe Animate CC. Database yang digunakan adalah SQLite.Kata kunci: Penyakit Timun, Android, Sistem Pakar, Dempster Shafer Abstract— Information technology can hardly be separated from various aspects of human life, because the ease of accessing information is one of its uses. Farmers do not understand the types of diseases in cucumber plants, so the process of handling cucumber plants is slow. Dempster-Shafer is known for its Frame of Discrement which is denoted by θ. This frame is a universe of discussion from a set of hypotheses. An expert system is generally defined as a system designed to model problem-solving abilities like a human expert. Identification of the problem in this study is damage to cucumber plants due to the difficulty of identifying diseases in cucumber plants. the scope / limitation of the problem in this study. The disease data to be studied were 6 diseases, the symptom data to be studied were 12 symptoms. The method used in diagnosing diseases in cucumber plants is the Dempster Shafer method. The application used is the Adobe Animate CC application. The database used is SQLite.Keywords: Cucumber Disease, Android, Expert System, Dempster Shafer
Studi Kelayakan Bisnis Studi Kasus Di Umkm Jagung Goreng Sukma, Payakumbuh
Authors: Marlina Winny Alna 
Published: June 2021

<p>Sukma Fried Corn Business is one of fried corn MSME business that is developing in Payakumbuh. This business has problems in the marketing, technical, and environmental aspects. Feasible study or business feasibility study is very useful for MSME owners, because it helps them in terms of product design and variety, waste management, production optimization by modifying the layout, management and organizational aspects which are common problems for MSMEs. The target of this research is to make standard product variants and packaging and modified layout. The Research Method is Qualitative descriptive. The data collection technique used in this study was the direct observation of MSMEs and focused on observing : Production System, Layout, Machines and equipment used and Waste generated. Results: In terms of market and marketing aspects, Sukma Fried Corn is innovating in adding flavor variants for its products. It is conducting promotions with both electronic and printed medias, to expand the reach of the target markert. In addition, it also created a unique and attractive product packaging design so that consumers can easily recognize their products. Concerning the layout of the facility, Sukma fried corn is working on separating the frying room and the packing room</p>
Efeitos do treinamento resistido e da suplementação com whey proteins sobre os marcadores creatinina e ureia de ratos
Authors: Vieira Elaine Paiva , Navarro Antonio Coppi , Silva Alanna Joselle Santiago , Navarro Francisco 
Published: June 2021

Introdução: Dietas hiperproteicas aumentam a concentração de ureia e ácidos, provenientes do metabolismo das proteínas. Portanto, o uso de altas doses de whey proteins precisa ser verificado frente aos seus efeitos sob a função renal. Objetivo: Avaliar o efeito do consumo de 2 g kg-1 d-1 e 4 g kg-1 d-1 whey proteins sobre marcadores bioquímicos creatinina e ureia após 12 semanas de treinamento resistido em ratos Wistar. Métodos: Amostra composta por 52 ratos Wistar machos alocados em 6 grupos. O protocolo teve duração de 12 semanas de treinamento resistido com suplementação diária de whey proteins. A determinação da concentração dos marcadores bioquímicos foi constituída de leitura em absorbância e equação específica dos parâmetros creatinina e ureia. Resultados: A relação creatinina foi significativamente maior apenas no grupo controle em relação aos grupos suplementados e ao treinado controle. A maior excreção de creatinina de 24h (mg/kg) no grupo treinamento resistido e suplementado em comparação ao treinamento controle demonstra possível efeito do treinamento resistido sobre o aumento da massa muscular associada a dose de 4 g kg-1 d-1. Conclusão: O tratamento de ratos machos Wistar suplementados com whey proteins nas doses de 2 g/kg/dia e 4 g kg-1 d-1 durante 12 semanas não resultou em prejuízo de função renal.
Editorial: Exercício resistido e suplementação proteica influenciam na função renal?
Authors: Oliveira Igor Alonso Andrade de , Santos Pedro Henrique Silva 
Published: June 2021

A insuficiência renal (IR) é caracterizada pela perda da capacidade dos rins em filtrar os resíduos metabólicos, sais e líquidos sanguíneos. As principais causas desta moléstia são a hipertensão arterial sistêmica e a diabetes mellitus descontrolada [1,2]. Entretanto, outras causas são descritas, como o uso de fármacos nefrotóxicos, desidratação prolongada, infecção e outros fatores que contribuem para a lesão renal [1]. A IR pode ser classificada em aguda (rápida e reversível) e crônica (gradual, lenta e sem reversibilidade) [1,2]. Estas doenças representam um grave problema de saúde pública no Brasil, estima-se que 134 mil doentes renais crônicos necessitam de terapia substitutiva (hemodiálise) [3]. Estes números crescem a cada ano, somente no ano de 2018 foram diagnosticados 42.546 novos casos de indivíduos que necessitaram desta terapia [3].
Synthesis of Low Cost Titanium Silicalite-1 Zeolite for Highly Efficient Propylene Epoxidation
Authors: Liu Meng , Huang Zihan , Wei Wei , Wang Xiangyu , Wen Yiqiang 
Published: June 2021

Developing an effective and low-cost system to synthesize titanium silicalite-1 (TS-1) zeolite is desirable for a range of industrial applications. To date, the poor catalytic activity of the synthesized zeolite due to the low amount of framework titanium and large crystal size is the main obstacle limiting the widespread application of this material. Moreover, a large amount of wastewater is often produced by the existing synthesis process. Herein, a green and sustainable route for synthesizing small-crystal TS-1 with a high fraction of framework Ti was demonstrated via a seed-assisted method using a tetrapropylammonium bromide (TPABr)-ethanolamine hydrothermal system. The influence of the synthesis conditions on the physicochemical properties and catalytic activities of TS-1 was investigated. With the assistance of nanosized S-1 seeds, the incorporation of Ti into the framework of TS-1 was promoted, and the crystallization rate was effectively accelerated. After alkaline etching, the obtained hierarchical TS-1 had higher catalytic activity towards propylene epoxidation with an extremely high turnover frequency of 1,650 h−1. Furthermore, the mother liquid during the hydrothermal reaction could be reused for the next synthesis procedure. Consequently, utilization ratios of both ethanolamine and TPABr exceeding 95% were achieved by recycling the mother liquid. This low-cost approach for reducing wastewater could be easily scaled up to provide a promising synthesis method for the industrial production of TS-1 and other topological zeolites.
The Impact of Post-contrast Acute Kidney Injury on In-hospital Mortality After Endovascular Thrombectomy in Patients With Acute Ischemic Stroke
Authors: Laible Mona , Jenetzky Ekkehart , Möhlenbruch Markus Alfred , Bendszus Martin , Ringleb Peter Arthur , Rizos Timolaos 
Published: June 2021

Background and Purpose: Clinical outcome and mortality after endovascular thrombectomy (EVT) in patients with ischemic stroke are commonly assessed after 3 months. In patients with acute kidney injury (AKI), unfavorable results for 3-month mortality have been reported. However, data on the in-hospital mortality after EVT in this population are sparse. In the present study, we assessed whether AKI impacts in-hospital and 3-month mortality in patients undergoing EVT.Materials and Methods: From a prospectively recruiting database, consecutive acute ischemic stroke patients receiving EVT between 2010 and 2018 due to acute large vessel occlusion were included. Post-contrast AKI (PC-AKI) was defined as an increase of baseline creatinine of ≥0.5 mg/dL or &gt;25% within 48 h after the first measurement at admission. Adjusting for potential confounders, associations between PC-AKI and mortality after stroke were tested in univariate and multivariate logistic regression models.Results: One thousand one hundred sixty-nine patients were included; 166 of them (14.2%) died during the acute hospital stay. Criteria for PC-AKI were met by 29 patients (2.5%). Presence of PC-AKI was associated with a significantly higher risk of in-hospital mortality in multivariate analysis [odds ratio (OR) = 2.87, 95% confidence interval (CI) = 1.16–7.13, p = 0.023]. Furthermore, factors associated with in-hospital mortality encompassed higher age (OR = 1.03, 95% CI = 1.01–1.04, p = 0.002), stroke severity (OR = 1.05, 95% CI = 1.03–1.08, p &lt; 0.001), symptomatic intracerebral hemorrhage (OR = 3.20, 95% CI = 1.69–6.04, p &lt; 0.001), posterior circulation stroke (OR = 2.85, 95% CI = 1.72–4.71, p &lt; 0.001), and failed recanalization (OR = 2.00, 95% CI = 1.35–3.00, p = 0.001).Conclusion: PC-AKI is rare after EVT but represents an important risk factor for in-hospital mortality and for mortality within 3 months after hospital discharge. Preventing PC-AKI after EVT may represent an important and potentially lifesaving effort in future daily clinical practice.
The Interaction Between Fatty Acid Desaturase-2 (FADS2) rs174583 Genetic Variant and Dietary Quality Indices (DASH and MDS) Constructs Different Metabolic Phenotypes Among Obese Individuals
Authors: Khodarahmi Mahdieh , Nikniaz Leila , Abbasalizad Farhangi Mahdieh 
Published: June 2021

Background and Aim: Genetic variation in fatty acid desaturases (FADS) has previously been linked to several diet-related diseases. We aimed to determine whether the FADS2 rs174583 variant interacts with the Dietary Approach to Stop Hypertension (DASH) score and Mediterranean dietary score (MDS) to influence cardio-metabolic risk factors among obese adults.Methods: This cross-sectional study was performed among 347 apparently healthy obese adults (aged 20–50 years). Dietary quality indicator scores (DASH and MDS) were generated using a validated 147-item Food Frequency Questionnaire (FFQ). The FADS2 rs174583 variant was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The gene–diet interaction was analyzed by the ANCOVA multivariate interaction model.Results: A significant interaction was observed between rs174583 and adherence to the DASH score in relation to serum triglyceride (TG) concentration among the female group (PInteraction = 0.046); CT-genotype carriers who were assigned to the second tertile of DASH compared with those in the first tertile had a lower TG level (P &lt; 0.05). Another significant interaction was revealed between adherence to MDS score and rs174583 polymorphism on serum glucose levels (PInteraction = 0.044); the lowest mean of glucose level was observed in homozygous minor subjects (TT) in the third tertile of MDS, in comparison with other tertiles of this dietary index (P &lt; 0.05). There was a similar significant interaction between DASH and rs174583 in relation to diastolic blood pressure (PInteraction = 0.038) among the male group. Additionally, a significant positive association was found between TT genotype and odds of having high TG both in the crude (OR, 3.21; 95% CI, 1.02–10.14) and adjusted (OR, 3.58; 95% CI, 1.07–11.97) models, taking into account different confounders.Conclusion: Adherence to the dietary quality indicators (DASH and MDS) modified the relationship between FADS2 rs174583 polymorphism and cardio-metabolic risk factors in obese subjects. Prospective cohort studies are needed to confirm the results of our study.
Keratinocyte Growth Factor 2 Ameliorates UVB-Induced Skin Damage via Activating the AhR/Nrf2 Signaling Pathway
Authors: Gao Shuang , Guo Keke , Chen Yu , Zhao Jungang , Jing Rongrong , Wang Lusheng , Li Xuenan , Hu Zhenlin , Xu Nuo , Li Xiaokun 
Published: June 2021

Objective: Exposure to ultraviolet B (UVB) can cause skin damage through oxidative stress, DNA damage, and apoptosis. Keratinocyte growth factor (KGF) has been shown to reduce the content of intracellular reactive oxygen species (ROS) following UVB exposure, a role that is crucial for the efficient photoprotection of skin. The present study evaluated the photoprotective effect of KGF-2 on UVB-induced skin damage and explored its potential molecular mechanism.Methods: To evaluate the effect of KGF-2 on UVB-induced damage ex vivo, a human epidermal full-thickness skin equivalent was pretreated without or with KGF-2 and then exposed to UVB and the levels of histopathological changes, DNA damage, inflammation, and apoptosis were then evaluated. The ability of KGF-2 to protect the cells against UVB-inflicted damage and its effect on ROS production, apoptosis, and mitochondrial dysfunction were determined in HaCaT cells.Results: Pretreatment of the epidermis with KGF-2 ameliorated the extent of photodamage. At the cellular level, KGF-2 could attenuate ROS production, apoptosis, DNA damage, and mitochondrial dysfunction caused by UVB exposure. KGF-2 could also activate the aryl hydrocarbon receptor (AhR) to trigger the Nrf2 signaling pathway.Conclusion: Taken together, our findings suggested that KGF-2 could ameliorate UVB-induced skin damage through inhibiting apoptosis, reducing oxidative stress, and preventing DNA damage and mitochondrial dysfunction via regulating AhR/Nrf2 signaling pathway.
Qian Yang Yu Yin Granule Improves Renal Injury of Hypertension by Regulating Metabolic Reprogramming Mediated by HIF-1α/PKM2 Positive Feedback Loop
Authors: Qian Lichao , Ren Shuai , Xu Zhongchi , Zheng Yawei , Wu Lihua , Yang Ying , Wang Yixuan , Li Jie , Yan Shihai , Fang Zhuyuan 
Published: June 2021

Protection against hypoxia injury is an important therapeutic strategy for treating hypertensive nephropathy. In this study, the effects of Qian Yang Yu Yin granule (QYYY) on spontaneously hypertensive rats fed with high salt diet and HEK293T cells exposed to hypoxia were investigated. After eight weeks’ treatment of QYYY, blood pressure, serum creatinine, serum cystatin C, blood urea nitrogen, urinary β2-microglobulin, urinary N-acetyl-β-glucosaminidase, and urinary microalbumin were assessed. The changes of hypoxia-inducible factor-1α (HIF-1α), pyruvate kinase M2 (PKM2), glucose transport 1 (GLUT1), lactate dehydrogenase A (LDH-A), connective tissue growth factor (CTGF), transforming growth factor-β1 (TGF-β1), ATP, lactate, pyruvate, and pathology were also assessed in vivo. HEK293T cells pre-treated with QYYY and/or HIF-1α over expressing cells were cultured in a three gas hypoxic incubator chamber (5% CO2, 1% O2, 94% N2) for 12 h and then the expressions of HIF-1α, PKM2, GLUT1, LDH-A, CTGF, TGF-β1, ATP, lactate, and pyruvate were detected. Our results showed that QYYY promoted the indicators of renal inflammation and fibrosis mediated by HIF-1α/PKM2 positive feedback loop in vivo and vitro. Our findings indicated that QYYY treated hypertensive nephropathy by regulating metabolic reprogramming mediated by HIF-1α/PKM2 positive feedback loop.
Gender Differences in Anxiety, Depression, and Nursing Needs Among Isolated Coronavirus Disease 2019 Patients
Authors: Li Yifei , Li Juan , Yang Zhen , Zhang Jie , Dong Lili , Wang Fusheng , Zhang Jingping 
Published: June 2021

ObjectiveThis study explored gender differences in anxiety, depression, and nursing needs among isolated Coronavirus Disease 2019 (COVID-19) patients, with a particular focus on the influencing factors. The main goal was to elucidate breakthrough points and intervention targets for psychological counseling aimed at the promotion of overall health during isolation treatment.MethodsA survey was conducted to obtain information about the nursing needs of COVID-19 patients, with mental health assessed via the Hospital Anxiety and Depression Scale (HADS). Participants included 219 isolated COVID-19 patients at a Wuhan module hospital in Hubei province, China.ResultsA total of 216 valid questionnaires were collected (98.63% retrieval rate). Of these participants, 21.76% had anxiety symptoms, while 17.59% had depression symptoms. Colleagues infected with COVID-19 (OR = 3.896, 95%CI: 1.555–9.764, P = 0.004) were the main influencing factors for anxiety symptoms, while marital status (OR = 2.700, 95% CI: 1.033–7.055, P = 0.043) and family members infected with COVID-19 (OR = 2.969, 95% CI: 1.243–7.095, P = 0.014) were the main influencing factors for depression symptoms. As for gender, male patients were generally more prone to depression and anxiety than female patients, especially those who were infected with colleagues. On the other hand, female patients reported greater concerns about safe treatment environments and communication with medical staff.ConclusionThis study found gender-based differences regarding the factors influencing anxiety and depression in isolated COVID-19 patients, with males reporting a greater general tendency for symptoms. On the other hand, female patients reported greater overall psychological nursing needs than males. Targeted nursing should thus be implemented to address specific psychological characteristics and nursing needs.
Obsessive-Compulsive Symptoms, Polygenic Risk Score, and Thalamic Development in Children From the Brazilian High-Risk Cohort for Mental Conditions (BHRCS)
Authors: Ravagnani Salto Ana Beatriz , Santoro Marcos L. , Hoexter Marcelo Q. , Jackowski Andrea Parolin , Pan Pedro M. , Rosário Maria Conceição , Belangero Sintia I. , Alvarenga Pedro Gomes , Doretto Victoria Fogaça , Fumo Afonso Mazine Tiago , Batistuzzo Marcelo C. , Macul Ferreira de Barros Pedro , Timpano Kiara R. , Ota Vanessa K. , Rohde Luis Augusto , Miguel Euripedes Constantino , Leckman James F. , Zugman André 
Published: June 2021

Background: Thalamic volume measures have been linked to obsessive-compulsive disorder (OCD) in children and adolescents. However, it is unclear if alterations in thalamic volumes occur before or after symptom onset and if there is a relation to the presence of sub-clinical obsessive-compulsive symptoms (OCS). Here, we explore the relationship between OCS and the rate of thalamic volume change in a cohort of children and youth at high risk to develop a mental disorder. A secondary aim was to determine if there is a relationship between OCS and the individual's OCD polygenic risk score (OCD-PRS) and between the rate of thalamic volume change and the OCD-PRS.Methods: The sample included 378 children enrolled in the longitudinal Brazilian High-Risk Cohort for Mental Conditions. Participants were assessed for OCS and the symmetrized percent change (SPC) of thalamic volume across two time-points separated by 3 years, along with the OCD-PRS. Zero-altered negative binomial models were used to analyze the relationship between OCS and thalamic SPC. Multiple linear regressions were used to examine the relationship between thalamic SPC and OCD-PRS.Results: A significant relationship between OCS and the right thalamus SPC (p = 0.042) was found. There was no significant relationship between changes in thalamic volume SPC and OCD-PRS.Conclusions: The findings suggest that changes in the right thalamic volume over the course of 3 years in children may be associated to OCS. Future studies are needed to confirm these results and further characterize the specific nature of OCS symptoms associated with thalamic volumes.
Problematic Gaming and Sleep: A Systematic Review and Meta-Analysis
Authors: Kristensen Joakim H. , Pallesen Ståle , King Daniel L. , Hysing Mari , Erevik Eilin K. 
Published: June 2021

Problematic gaming has been linked to poor sleep outcomes; however, these associations have not yet been synthesized quantitatively. This review employed a meta-analysis to investigate the relationship between problematic gaming and sleep-related outcomes. A search of Medline, Embase, Web of Science, PsycINFO, and Google Scholar identified a total of 763 studies, including 34 studies (n = 51,901 participants) eligible for inclusion. Papers were included if available in any European language, addressed problematic gaming, contained original data, and provided sufficient data for calculation of effect sizes. Two researchers independently extracted data using pre-defined fields including quality assessment. Sleep-related outcomes were meta-analyzed for sleep parameters that were reported by 5 or more papers. Significant overall effects were found for sleep duration (g = −0.238, 95% CI = −0.364, −0.112), poor sleep quality (OR = 2.02, 95% CI = 1.47, 2.78), daytime sleepiness (OR = 1.57, 95% CI = 1.00, 2.46) and sleep problems (OR = 2.60, 95% CI = 1.94, 3.47). Between-study heterogeneity was detected for all meta-analyses. Subgroup analyses showed a higher inverse effect size for adolescent samples compared to adult or non-specific age samples in terms of sleep duration. For daytime sleepiness, a larger effect size was found for studies based on single-item sleep measures compared to multi-item sleep measures. For sleep problems, the subgroup analysis showed the opposite with a higher effect size for studies based on single-item sleep measures than multi-item sleep measures. Across all sleep parameters, problematic gamers consistently reported a more adverse sleep status than non-problematic gamers.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/; record ID: CRD42020158955.