bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on intestinal flora of acupoint catgut embedding intervention in female patients with abdominal obesity: Study protocol for a randomized controlled trial
Authors: Li Qifu , Feng JiaLei , Zhang Xinghe , zeng Xuanxiang , Zhao Siwen , Kong Meng , Zheng Yunqiu , Xing Chonghui , Guo Taipin 
Published: December 2021

Abstract
Background

With high morbidity, and many complications, obesity has become a global public health problem, and attracted extensive attention from the medical community. Previous studies have suggested that acupoint catgut embedding (ACE) is a safe and effective therapy for abdominal obesity (AO). However, the investigation of its mechanisms remains limited. The purpose of this study is to observe the effect of ACE intervention in AO on the intestinal flora, to reveal its site of action and therapeutic mechanisms, and provide further theoretical support for ACE in the clinical treatment of AO.
Methods/design:

A total of 60 eligible female participants diagnosed with AO will be recruited in this study. They will be blinded to group assignment and randomized to either ACE group, sham ACE group, and waiting list (WL) group, with 20 patients in each group. Each patient in the two ACE-based groups will receive one ACE treatment per week for 12 consecutive weeks. This study will focus on analyzing the intestinal flora changes elicited by ACE treatment. The body mass index (BMI), waist circumference (WC), body weight (BW), blood pressure (BP), heart rate (HR), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL), visual analogue score (VAS) of appetite, and the Gastrointestinal Symptom Rating Scale (GSRS) will be used to evaluate the clinical efficacy of ACE treatment by making assessments before and after treatment. High-throughput 16S ribosomal ribonucleic acid (rRNA) gene sequencing will be used to detect changes in the intestinal flora composition before and after treatment. The repeated measures analysis of variance (3 groups × 2-time points ANOVA) will be employed to analyze numerical variables of the clinical and intestinal flora data generated in the study.
Discussion

The results of this trial are expected to further confirm that ACE can effectively relieve AO and verify the intervention mechanisms of ACE on intestinal flora in patients with AO.
Trial registration:

Chinese Clinical Trial Registry, ChiCTR2100048853. Registered on July 19, 2021. https://www.chictr.org.cn/showproj.aspx?proj=130531
Growth of Palm Trees and Woods in the Urban Environment
Authors: Silva Valéria de Fatima , Jacovine Laércio Antônio Gonçalves , Martini Angeline , Torres Carlos Moreira Miquelino Eleto , Faustino Isabella Salgado , de Freitas Mariany Filipini , de Carvalho Daniel Leal , de Castro Cassio Luciano Vieira , Silva Andressa Marques da , Mota Pedro Henrique Santos 
Published: December 2021

Abstract
Trees in the urban environment provide several ecosystem benefits to the population, such as decreasing temperature, increasing humidity, shading, improving air quality, as well as physical and mental well-being. These can be enhanced through the knowledge of the growth of the trees in function of the characteristics of the place where they are inserted. Thus, the objective was to estimate the growth in diameter, height and volume of forest species in the urban environment, in Viçosa, Minas Gerais, Brazil. For this, woody individuals and palm trees present in the urban afforestation of the headquarters campus of the Federal University of Viçosa were selected based on age and had their diameter, breast height and height measured. Allometric equations specific to the study site were used to estimate their volume, and through the relationship with age, the average annual increment was obtained. Woody individuals showed a growth rate in volume of 0,0279 ± 0,0274 m³ year-1 and palm trees, 0,0139 ± 0,0119 m³ year-1. The differences in the average annual increase in volume found between woody individuals and palm trees may be due to morphological differences that affect the secondary growth of individuals. The growth rate of trees in the urban environment is higher when compared to those in forest fragments and experimental plantings. The decrease in growth rates with increasing age was expected due to the relationship between them being of the non-linear type, following a sigmoidal model.
The Effects of Custom-made Foot Orthoses on Foot Pain, Foot Function, Gait Function and Freeliving Walking Activities in Psoriatic Arthritis (PsA) Patients: a Pre-experimental Trial
Authors: Walha Roua , Dagenais Pierre , Gaudreault Nathaly , Beaudoin-Côté Gabriel , Boissy Patrick 
Published: December 2021

Abstract
Introduction: Foot involvement is a major concern in psoriatic arthritis (PsA) as it can lead to severe levels of foot pain and disability as well as reduced mobility and quality of life. Previous studies have shown moderate efficacy in reducing foot pain and disability in rheumatoid arthritis patients with the use of custom-made foot orthoses (CFO). However, evidence on the efficacy of CFO in PsA patients is lacking.Objectives: Explore the effects of CFO on foot function, foot and lower limb pain, gait function, and freeliving walking activities (FWA) in PsA patients.Methods: A Pre-experimental study including 20 PsA patients (mean age: 54.10 ± 9.06 y and disease duration: 11.53 ± 10.22 y), was conducted. All the participants received and wore CFO for a 7-week period. Foot and lower limb pain and foot function were measured before and after the intervention using the numerical rating scale (NRS) and the foot function index (FFI). Gait function was assessed from gait spatiotemporal parameters (STPs) extracted during a 10-meter walk test with an gait analysis system (Mobility Lab). Freeliving walking activities (step count, freeliving cadence, time spent in different ambulatory physical activities (APA)) were recorded over 7 days using accelerometer data collected from an instrumented sock worn during waking hours.Results: PsA patients reported severe baseline levels of foot pain (54.46 ± 14.58 %) and disability (46.65 ± 16.14%) on the FFI. Statistically and clinically significant improvements with large effect sizes (Cohen’s effect size > 1, p<0.005) in foot pain and foot function were observed after 7 weeks of CFO use. A significant correlation (r=-0.64, p<0.01) between CFO wear time after the adaption period and foot function on the FFI at 7 weeks was observed. However, no significant changes were demonstrated for gait STP nor for free-living walking activities after 7 weeks of CFO use.Conclusion: Results support the clinical and biomechanical plausibility of using CFO with PsA patients to reduce pain and improve foot function. Larger and controlled studies are needed to confirm these findings and a multidisciplinary approach including the prescription of exercise therapy and physiotherapy in combination with CFO could be relevant to improve STP and promote APA in PsA patients.Study registration: ClinicalTrials.gov, NCT05075343, Retrospectively registered on 29 September 2021.
Faktor Penentu Setting Ruang Destinasi Wisata terhadap Spending Rate Wisatawan di Pantai Baron Yogyakarta
Authors: Satria Wastuwedha Kidung Dwi , Subroto Tarcicius Yoyok Wahyu 
Published: December 2021

Title: Determinant Factors of Tourism Destination Space Setting to Tourist Spending Rate at Baron Beach Yogyakarta

Gunungkidul Regency is popular for a beach tourist destination, committed for improving tourist’s arrival. However, for the past few years, the Original Local Government (OLG) of the tourism sector decreased by 2017, 2018, and 2019. Beach tourism provides the biggest percentage of The Original Local Government Revenue compared to other tourism destinations. One of the indicators that affects revenue from the tourism sector is the tourist spending rate. Therefore, it requires significant effort to identify the determinant factors of space settings that affect spending rates in Baron Beach. The research method used is mix method with the data collection technique used Behavioral Mapping that consist of Place Centered Mapping, Person Centered Mapping, and Time Budget. The conclusion of this research is the space setting of the Baron beach tourist destination is determined by 2 aspects of space and time. (a) The aspect of space is divided into 3 categories. They are high, medium, and low. (b) The aspect of time is divided into 3 categories. They are long, medium, and short. The determinant factors of space settings that affect spending rates in tourism destinations of Baron Beach are (a) spatial factor, (b) amenity factor (c) time factor.
Research on prediction method of section convergence and deformation of shield tunnel in operation period based on deep learning
Authors: Sun Fei , Zheng Haolong , Li Changjun 
Published: December 2021

Presently, the tunnel construction of China is changing from “mainly construction” to “equal emphasis on construction and maintenance”. In this context, tunnel structure inspection, monitoring, and maintenance technologies have developed rapidly. However, the effective use and in-depth mining of massive data has always been the most difficult point in this field. Based on deep learning technology, this paper carries out in-depth mining of the multi-source data of the tunnel structure, so that the convergence and deformation of the section during the operation of the shield tunnel is predicted in a short time. Taking the Nanjing Yangtze River shield tunnel project as an example, the indicators are screened based on the fluctuations of the pair wise correlation coefficients of all monitoring indicators. And based on the Keras (a high-level neural network API) framework, a short-term prediction model of the convergent deformation of the shield tube section at this location is established. The results show that the model successfully predicts the convergence of the tunnel section in the next 10 days, and the prediction accuracy reaches 93.6 %. The short-term prediction of key sections and the near warning sections is realized, so as to prevent it in advance.
PREVENÇÃO DO CÂNCER CERVICOUTERINO: UMA AÇÃO REALIZADA PELOS ENFERMEIROS DA ESTRATÉGIA SAÚDE DA FAMÍLIA?
Authors: Silva Alexandre Bezerra , Rodrigues Maísa Paulino , Oliveira Amanda Paulino de , Melo Ricardo Henrique Viera de 
Published: December 2021

Objetivo: Analisou-se as intervenções de prevenção e promoção da saúde relacionadas a detecção precoce do câncer cervicouterino desenvolvidas pelos enfermeiros das equipes da Estratégia Saúde da Família (ESF) do município de Assú/RN. Métodos: Foi realizado um estudo descritivo, com abordagem qualitativa, junto a 11 enfermeiros, no mês de julho de 2016, representando 61% dos enfermeiros lotados da ESF. O material coletado, através de entrevistas abertas, foi submetido à análise de conteúdo temático proposta por Bardin. As falas produziram duas categorias de análise: práticas preventivas do câncer cervicouterino e práticas de educação/promoção da saúde. Resultados: Os resultados apontam que as ações relacionadas a prevenção e controle do câncer cervicouterino realizadas pelos enfermeiros, ainda são incipientes. O atendimento, às mulheres, ocorre por meio de demanda espontânea, não havendo o necessário rastreamento, visando evitar o câncer de colo uterino na faixa etária preconizada pelo Ministério da Saúde. As ações educativas são esporádicas e implementadas, principalmente, por ocasião das Campanhas promovidas pelo Ministério da Saúde, como por exemplo, o outubro Rosa. Conclusões: Faz-se necessário que as ações dos enfermeiros da ESF, no que concerne a detecção precoce e rastreamento do câncer do colo do útero sejam redirecionadas e, ademais, que a educação em saúde possa ser implantada de forma a promover o empoderamento das mulheres com vistas ao autocuidado e a promoção da saúde.
ASSISTÊNCIA À SAÚDE DA CRIANÇA: UMA ANÁLISE MULTIDIMENSIONAL DOS SERVIÇOS DE SAÚDE
Authors: Pereira Marcelo de Araújo Abreu , Souza Dandara Rayssa Silva de , Souza Ana Mayara Gomes de , Ferreira Tainara Lorena dos Santos , Andrade Fábia Barbosa de 
Published: December 2021

Introdução: A saúde infantil constitui-se como ações e práticas com intuito de proporcionar um atendimento integralizado a saúde da criança, vista como area prioritária no âmbito do cuidado. Objetivo: avaliar a qualidade da assistência prestada à criança desde os primeiros momentos de vida até a inserção e acompanhamento no programa de puericultura. Metodologia: Trata-se de um estudo descritivo, avaliativo de abordagem quantitativa, com 200 mulheres mães/responsáveis por crianças menores de dois anos, atendidas em Unidades Básicas de Saúde, no município de Santa Cruz/RN. Resultados: Com relação os cuidados ofertados, observou-se que o apgar entre 7 a 10 no primeiro e quinto minuto foi atribuído na maioria da amostra; Tratando-se do estímulo ao vínculo materno/infantil, a maioria das mães afirmou que permaneceu junto ao seu filho no mesmo quarto após o parto; bem como amamentou seu filho logo após o parto. Por fim, sobre as condições de saúde no primeiro mês de vida, a maioria da relatou que não houve internamento por nenhum tipo de complicação. Conclusão: Observou-se que as práticas assistenciais foram realizadas na sua maioria, destacando o comprometimento dos profissionais atuantes nos serviços de saúde, o que confere aos serviços uma boa qualidade frente às demandas solicitadas. Porém as fragilidades e desafios ainda existentes demonstram a necessidade de estratégias para implementação de medidas estratégicas em busca de melhores resultados.
Delineating Calcium Signaling Machinery in Plants: Tapping the Potential
through Functional Genomics
Authors: Ghosh Soma , Bheri Malathi , Pandey Girdhar K. 
Published: December 2021

:
Plants have developed calcium (Ca2+) signaling as an important mechanism of regulation
of stress perception, developmental cues, and responsive gene expression. The post-genomic
era has witnessed the successful unravelling of the functional characterization of genes and the
creation of large datasets of molecular information. The major elements of Ca2+ signaling machinery
include Ca2+ sensors and responders such as Calmodulins (CaMs), Calmodulin-like proteins
(CMLs), Ca2+/CaM-dependent protein kinases (CCaMKs), Ca2+-dependent protein kinases (CDPKs),
Calcineurin B-like proteins (CBLs) as well as transporters, such as Cyclic nucleotide-gated channels
(CNGCs), Glutamate-like receptors (GLRs), Ca2+-ATPases, Ca2+/H+ exchangers (CAXs) and
mechanosensitive channels. These elements play an important role in the regulation of physiological
processes and plant responses to various stresses. Detailed genomic analysis can help us in the
identification of potential molecular targets that can be exploited towards the development of
stress-tolerant crops. The information sourced from model systems through omics approaches
helps in the prediction and simulation of regulatory networks involved in responses to different stimuli
at the molecular and cellular levels. The molecular delineation of Ca2+ signaling pathways
could be a stepping stone for engineering climate-resilient crop plants. Here, we review the recent
developments in Ca2+ signaling in the context of transport, responses, and adaptations significant
for crop improvement through functional genomics approaches.
Evaluation of the Relationship between Fat Volume and Nephrolithiasis
Authors: Senel Samet , Tastemur Sedat , Olcucuoglu Esin , Uzun Emre 
Published: December 2021

Objective:
To examine the relation between perirenal fat volume, which is one of the visceral
fat measurements, and kidney stones.

Method:
169 patients admitted to our clinic between January 2018 and May 2021 were included
in the study. The patients were divided into 2 groups as Control Group and Unilateral Kidney
Stone Group (88 patients with unilateral kidney stones). Contrast-enhanced abdominal computed
tomography scans were used to measure perirenal fat volume and the results were transferred to
workstations. The total perirenal fat volumes in the bilateral kidneys of patients were compared between
the two groups. The perirenal fat volume in stone-bearing and non-stone bearing kidneys of
patients were also compared.

Results:
The total perirenal fat volume was higher in the Unilateral Kidney Stone Group than in
the other groups and the perirenal fat volume of the patients in this group was higher in the stone
bearing kidney (295.6±164.4cm3) than in the non-stone bearing kidney (273.1±179.6cm3). In the
ROC analysis, it was concluded that total perirenal fat volume>387cm3 increased the risk of kidney
stones. Presence of hypertension, presence of hyperlipidemia and total perirenal fat
volume>387cm3 were found to be independent risk factors for the presence of kidney stones.

Conclusion:
Perirenal fat volume is higher in stone bearing kidneys compared to non-stone bearing
kidneys. Therefore, stone formation in a kidney is directly related to the perirenal fat volume of
that kidney. Also, total perirenal fat volume>387cm3 increases the risk of kidney stones independently
of body mass index, and predicts it better.
Clozapine and COVID-19: A Case Report and Clinical Considerations
Authors: Fusick Adam J. , Lahiff Dylan , Chatham Peggy , Sullivan Gregory 
Published: December 2021

Background:
The emergence of coronavirus SARS-CoV-2, and the subsequent global
epidemic of COVID-19, brought with it innumerable new clinical experiences across all medical
specialties, and psychiatry is no exception. Individuals with serious mental illness, in particular
schizophrenia and related disorders, may be especially susceptible to coronavirus infection given
the overlapping risk factors of vulnerable sociodemographic status, increased challenges with quarantining
requirements, and limited compliance with “respiratory etiquette.” The case presented
here describes a patient with schizophrenia who was being managed on clozapine and who developed
symptomatic COVID-19 infection. Special care was taken to ensure that potential interactions
between clozapine and the associated COVID-19 treatments were safe for the patient’s mental and
physical wellbeing.

Case Presentation:
A 71-year-old schizophrenic Caucasian male is being managed with clozapine.
While hospitalized, the patient was screened positive for COVID-19 and was admitted to the ICU
due to his declining respiratory status. He was treated with both remdesivir and prednisone. He was
able to fully recover from his COVID-19 infection.

Conclusion:
The authors review the clinical characteristics of the case, highlighting both the overlapping
synergistic effects and antagonistic influences of clozapine therapy in combination with
COVID-19 and its associated treatments. A review of the literature offers an opportunity to examine
various frameworks for individualized clinical decision-making while making the case for
greater epidemiologic research into the optimal management of individuals with a psychotic disorder
who are diagnosed with COVID-19 infection.
Pharmacological Potentials and Nutritional Values of Tropical and Subtropical
Fruits of India: Emphasis on their Anticancer Bioactive Components
Authors: Narayanankutty Arunaksharan 
Published: December 2021

Background:
Fruits are an important dietary component, which supply vitamins, minerals,
as well as dietary fiber. In addition, they are rich sources of various biological and pharmacologically
active compounds. Among these, temperate fruits are well studied for their pharmacological
potentials, whereas tropical/subtropical fruits are less explored for their health impacts. In India,
most of the consumed fruits are either tropical or subtropical.

Objectives:
The present review aims to provide a health impact of major tropical and sub-tropical
fruits of India, emphasizing their anticancer efficacy. In addition, the identified bioactive components
from these fruits exhibiting anticancer efficacy are also discussed along with the patent literature
published.

Methods:
The literature was collected from various repositories, including NCBI, ScienceDirect,
Eurekaselect, and Web of Science; literature from predatory journals was omitted during the process.
Patent literature was collected from google patents and similar patent databases.

Results:
Tropical fruits are rich sources of various nutrients and bioactive components including
polyphenols, flavonoids, anthocyanin, etc. By virtue of these biomolecules, tropical fruits have
been shown to interfere with various steps in carcinogenesis, metastasis, and drug resistance. Their
mode of action is either by activation of apoptosis, regulation of cell cycle, inhibition of cell survival
and proliferation pathways, increased lipid trafficking or inhibiting inflammatory pathways.
Several molecules and combinations have been patented for their anticancer and chemoprotective
properties.

Conclusion:
Overall, the present concludes that Indian tropical/ subtropical fruits are nutritionally
and pharmacologically active and may serve as a source of novel anticancer agents in the future.
A Comparative Study of the Communication Profile of Typically Developing Children and Children with Receptive-Expressive Language Disorders: A Parental Perceptive
Authors: Varghese Aiswarya L. , Thomas Chinnu , Mohan Megha , Karuppali Sudhin 
Published: December 2021

Background:
Parental concerns pertaining to communication abilities are essential as it does aid in the identification of the children at risk of physical and mental health problems.

Objectives:
The current study followed a cross sectional study design. The study focussed on developing a questionnaire targeting the parental concerns in Typically developing (TD) children and children with Receptive-Expressive Language Disorders (CWRELD) between 3.7 and 6.6 years of age; to administer the developed questionnaire on parents of TD children and CWRELD; and to analyse and compare the concerns faced by parents of TD children and CWRELD across 3.7 and 6.6 years of age.

Methods:
Fifty-one parents of TD children and 51 parents of CWRELD participated in the study. The study was carried out in three phases- Phase I included the development and validation of questionnaire; Phase II included data collection using the developed questionnaire; and Phase III included performing statistical analysis. Descriptive statistics was done to determine the mean and standard deviation (SD) for both the TD and CWRELD groups.

Results:
The results revealed that the concerns exhibited by parents of CWRELD were significantly higher than that of parents of TD children. Chi square results indicated statistically significant findings across all the domains between TD children and CWRELD (p<0.05).

Conclusion:
The developed questionnaire can be used in clinical settings to help track parental concerns which may aid in the early identification of children at risk of various communication disorders. Additionally, this questionnaire may be considered for monitoring parental concerns throughout the course of the intervention program.