bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bipolar transurethral resection of large prostate >100 gm: single center experience
Authors: Mamdoh Hussein , Elbendary Mohamed , Habib Enmar , Hassan Ayman 
Published: February 2021

Background: Benign prostatic hyperplasia (BPH) is a common urological finding in aged men. It may be associated with deterioration of the patient’s quality of life as it may cause lower urinary tract symptoms (LUTS), urinary retention, and deterioration of the renal function. The gold standard treatment option is transurethral resection of prostate (TURP) in patients with prostate up to 80g in size. However, in larger prostates (>80 g), laser or bipolar enucleation of the prostate is considered the treatment of choice. In this setting, we decided to report a single center experience with bipolar TURP for large prostates (>100 g).Methods: The database of our center was retrospectively reviewed to identify all the patients undergoing bipolar TURP for large prostates (>100 g) between January 2018 and January 2019. The following data was collected, age, prostate size in grams, urinalysis and culture. Moreover, the operative time, resected tissue weight, complications, hospitalization, and catheterization times were also collected Furthermore, urinary tract ultrasound (including the assessment of post voiding residual urine [PVR]), uroflowmetry (including the peak urinary flow [Qmax]), and IPSS were assessed preoperatively, at one, and 12 months postoperatively.Results: Eight were retrieved from the database and were included in the current study. The median prostate size was 115 grams. All cases were completed by B-TURP without the need for conversion to open prostatectomy and the operative time ranged from 65 to 90 minutes. All the patients showed significant improvement of the IPSS, Qmax, and PVR at one and 12 months follow up. Only three patients in the current series (37.5%) suffered from complications. Conclusions: B-TURP can be used safely for the management of large prostates (>100 g); however, further studies are required to confirm these results.
A comparative study of endoscopic verses conventional septoplasty
Authors: Shamakhi Radeif , Juribi Wael A. , Alzarei Ali H. , Mubaraki Musleh H. 
Published: February 2021

<p><strong>Background: </strong>Septoplasty is the surgical procedure for the correction of a deviated nasal septum. It can be achieved either with an endoscopic or a conventional approach. Endoscope allows better visualization and magnification, helps in enhancing surgical procedure accuracy and there is also no need for overexposure, excessive septal anatomy manipulation, osseocartilaginous disarticulation of the nasal septum and further resection. Endoscopic septoplasty is not only used to address symptomatic nasal obstruction, but also to improve visualization in sinus surgery. This study was conducted to compare intra operative bleeding of the two techniques in treatment of deviated nasal septum.</p><p><strong>Methods: </strong>The present study was conducted in the department of otorhinolaryngology, Prince Mohammed hospital and Aseer central hospital. The study was conducted in 30 patients having symptomatic DNS, in the age group of 18-50 years after obtaining their consent. The patients were randomly divided into two groups of 15 patients each. Group A (n=15) underwent endoscopic septoplasty and group B (n=15) underwent conventional septoplasty under general anesthesia. The two groups were compared regarding intra operative bleeding of surgery.</p><p><strong>Results: </strong>In conventional septoplasty there is more bleeding during surgery but in Endoscopic septoplasty the bleeding is less during surgery.</p><p><strong>Conclusions: </strong>The endoscopic septoplasty offers an alternative to conventional technique with superior visualization, excellent illumination and excellent tool for teaching. It preferred for posterior deviation, whereas conventional septoplasty is still preferred for anterior deviation.</p>
Desarrollo de una base de datos para el estudio de los aditivos alimentarios en las asignaturas de química de alimentos
Authors: Martín Gómez Juan , Moyano Cañete Mª Lourdes , Zea Calero Luis , Mérida García Julieta , Pérez Serratoso María 
Published: February 2021

Las TIC o tecnologías de la información y comunicación son una herramienta que permite un mayor desarrollo personal para el alumno, siendo él el protagonista en lugar del profesor. Con estas herramientas se adquieren diferentes competencias básicas necesarias para los alumnos universitarios, como son la capacidad de trabajo en equipo, la creatividad, el aprendizaje autónomo, entre otras. Además, los alumnos fueron partícipes en la evaluación de las actividades fomentando así también las competencias básicas relacionadas con la evaluación, como la reflexión.
El objetivo de este trabajo era desarrollar una base de datos sobre aditivos, incluyendo información sobre clasificación, fórmula química, grupo al que pertenece, masa molecular, toxicidad, ingesta diaria admitida. La base de datos se crea mediante la participación de alumnos en diferentes actividades de búsqueda de información. Esta base de datos estaría disponible para los alumnos y serviría a su vez al profesor para la realización de nuevas actividades a través de la plataforma Moodle de la Universidad de Córdoba.
Endoscopic Resection Combined with the Cryoballoon Focal Ablation system in the Porcine Normal Esophagus: A Preclinical Study
Authors: Sunakawa Hironori , Yoda Yusuke , Takeshita Nobuyoshi , Hasegawa Hiro , Takashima Kenji , Kadota Tomohiro , Fujita Takeo , Akimoto Tetsuo , Fujii Satoshi , Yano Tomonori 
Published: February 2021

Abstract
Background: The Cryoballoon focal ablation system (CbFAS) for dysplastic Barrett’s esophagus is simple, time-saving and has high therapeutic efficacy. This study aimed to evaluate the technical feasibility and tissue damage with combination therapy of endoscopic resection (ER) and CbFAS in porcine models.Methods: Three pigs (A, B, and C) were included, and all ER procedures were performed by endoscopic mucosal resection using the Cap method (EMR). Combination therapy for each pig was performed as follows: (a) CbFAS was performed for a post-EMR mucosal defect for Pig A; (b) CbFAS for post-EMR scar for Pig B, and (c) EMR for post-CbFAS scar for Pig C. All pigs were euthanized at 32 days after the initial procedure, and the tissue damage was evaluated.Results: All endoscopic procedures were followed as scheduled. None of the subjects experienced anorexia, rapid weight loss, bleeding, and perforation during the observation period. They were euthanized at 32 days after the initial endoscopic procedure. On histological assessment, there was little difference between the tissue that was treated with CbFAS alone and that treated with CbFAS in combination with ER.Conclusion: Combination therapy with ER and CbFAS can be technically feasible, and its outcome was not significantly different from CbFAS alone in terms of tissue damage.
Interventricular septal curvature as an additional echocardiographic parameter for evaluating chronic thromboembolic pulmonary hypertension: A single-center retrospective study
Authors: Matsumura Akane , Shigeta Ayako , Kasai Hajime , Yokota Hajime , Terada Jiro , Yamamoto Keiko , Sugiura Toshihiko , Matsumura Takuma , Sakao Seiichiro , Tanabe Nobuhiro , Tatsumi Koichiro 
Published: February 2021

Abstract
Background: Noninvasive estimation of the actual systolic pulmonary artery pressure measured via right-sided heart catheterization (sPAPRHC) is important for the management of pulmonary hypertension, including chronic thromboembolic pulmonary hypertension (CTEPH). Evaluation related to the interventricular septum (IVS) is generally performed with only visual assessment and has been rarely assessed quantitatively in the field of echocardiography. Thus, this study aimed to investigate the utility of echocardiographic IVS curvature to estimate sPAPRHC in patients with CTEPH. Methods: Data of 72 patients with CTEPH were studied retrospectively. We estimated sPAPRHC using echocardiographic IVS curvature (esPAPcurv) and left ventricular eccentricity index (esPAPLVEI), and compared their ability to predict sPAPRHC with estimated sPAPRHC using tricuspid regurgitant pressure gradient (esPAPTRPG). Results: IVS curvature and LVEI were significantly correlated with sPAPRHC (r = - 0.52 and r = 0.49, respectively). Moreover, the IVS curvature was effective in estimating the sPAPRHC of patients with trivial tricuspid regurgitation (r = - 0.56) and in determining patients with sPAPRHC ≥70 mmHg with higher sensitivity (77.0%) compared to those with esPAPTRPG and esPAPLVEI. Conclusion: Our results indicate that the echocardiographic IVS curvature could be a useful additional tool for estimating sPAPRHC in CTEPH patients in whom accurate estimation of sPAPRHC using tricuspid regurgitant pressure gradient is difficult.
Simulation and Surface Topology of Activity of Pyrazoloquinoline Derivatives as Corrosion Inhibitor on the Copper Surfaces
Authors: Razavi Razieh , Zahedifar Mahboobeh , Ahmadi Sayed Ali 
Published: February 2021

Abstract
In the present study, interactions of pyrazolo [3,4-b]quinoline-3,5-dione derivatives on copper metal surface were considered using B3LYP/6-311 + + g(d,p) in water media and also interaction energies were simulated for all the chemical coordination’s of pyrazoloquinoline derivatives compounds. Moreover the original and novel results revealed that in all the chemical side effects and cases, pyrazoloquinoline derivatives compounds were located on the Cu metal surface. This shows that the most important desired direction is where the concentrated numbers of electron donor active atoms of inhibitor molecules interacted with the Cu metal surface atom. Furthermore the chemical Thermodynamic parameters were estimated for example: ∆G of chemical inhibitor complexes with the Cu metal surface. Density of the electron profile analysis and chemical electrostatic potential of nuclear charges in the molecule were applied to consider the nature of a number of probable interactions between Cu metal surface and inhibitors in terms of bond critical point (BCP). Finally chemical electronics parameters showed that the OH and NO2 pyrazoloquinoline derivatives have best interaction in chemical and surface media.
The different structure-function correlation as measured by OCT and Octopus perimetry cluster analysis in intracranial tumor and glaucoma patients
Authors: Li Xiaochun , Qin Jiayin , Cao Xiaoguang , Ren Zeqin , Cui Ting , Bao Yongzhen 
Published: February 2021

Abstract
BackgroundTo explore the correlation of visual field (VF) defect values and retinal nerve fiber layer (RNFL) thickness for the intracranial tumor and glaucoma patients. MethodsRetrospective analysis is performed for the intracranial and glaucoma patients, whose VF defect values measured with Octopus perimeter cluster analysis, and RNFL thickness and optic disk parameters measured with swept source OCT. The differences between VF and RNFL (included the data of optic disc) are calculated. The correlation between VF defect values and RNFL thickness are explored.Results43 eyes of 29 patients with the intracranial tumor and 39 eyes of 23 patients with the glaucoma are enrolled. Thickness of RNFL not only for the whole (360°), but also for the four quadrants are thinner in the glaucoma group than those of the intracranial tumor group (p<0.05). There is no significant difference of VF for those two groups. Stronger correlation for mean deviations (MD)s of VF ten clusters and RNFL thickness of OCT twelve sectors is found in the glaucoma patients, but few in the intracranial tumor patients. Logistic regression also shows the RNFL loss tending to the diagnosis of glaucoma, and the VF damage is inclined to the diagnosis of intracranial tumor.ConclusionsIntracranial tumor has a weak correlation between the RNFL thickness and Octopus VF MD, compared with that of glaucoma. OCT and Octopus VF might provide more helpful information for the antidiastole of intracranial tumor and glaucoma.
A Network Pharmacology-Based Study of the Mechanism of Renshen Baidu Powder in Treating Ulcerative Colitis
Authors: Jia Bo , Tan Xi-Yue , Liu Xing-Long , Li Xin-Yun 
Published: February 2021

Abstract
Ulcerative colitis (UC), one forms of chronic inflammatory bowel disease (IBD), is characterized by recurrent inflammation, and Renshen Baidu Powder (RSBDP) is often used as a traditional Chinese medicine prescription for treating of UC, but the pharmacological mechanisms remains unclear. This research aims to explore the mechanisms of RSBDP in the treatment of UC based on network pharmacology. Through multiple databases collected the compounds and targets, and constructed the network. The crossover genes enrichment analysis were performed by protein-protein interaction (PPI) construction and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Finally, 181 compounds and 266 targets were obtained. Potential candidate ingredients mainly include phytosterols, flavonoids, and coumarins, all of which have anti-inflammatory activities. GO and KEGG enrichment analysis suggested that RSBDP have anti-inflammatory and immunomodulatory effects. The effect of RSBDP on UC might be achieved by regulating the balance of cytokines (i.e., IL-6, TNF, IL-1) and the downstream mediators (i.e., STAT1, STAT3) in the immune system. And inflammation-, immune- and hypoxic-related pathways, like TNF, Toll-like receptors and HIF-1 signaling pathway. These results provide a theoretical basis for studying the effective substances of RSBDP in the treatment of UC and their mechanism of action for further research.
Analysis of Selection Signatures on the Z Chromosome of Bidirectional Selection Broiler Lines for the Aassessment of Abdominal fat Content
Authors: Wang Tao , Zhou Meng , Guo Jing , Guo Yuan-Yuan , Ding Kun , Wang Peng , Wang Zhipeng 
Published: February 2021

Abstract
Background: The discovery of selection signatures has enabled the identification of genomics regions under selective pressure, enhancing knowledge of evolutionary genotype-phenotypes. Sex chromosomes play an important role in species formation and evolution. Therefore, the exploration of selection signals on sex chromosomes has important biological significance.Results: In this study, we used the Cross Population Extend Haplotype Homozygosity Test (XPEHH), F-statistics (Fst) and EigenGWAS to assess selection footprints on the Z chromosome in 474 broiler chickens via Illumina chicken 60K SNP chips. SNP genotype data were downloaded from publicly available resources. We identified 35 selection regions, amongst which 1, 9 and 27 were identified by XPEHH, Fst, and EigenGWAS, respectively. Each end of the Z chromosome appeared to undergo the highest levels of selection pressure. A total of 219 candidate genes were located in 35 selection regions, some of which mediated lipogenesis, fatty acid production, fat metabolism, and fat decomposition, including FGF10, ELOVL7, and IL6ST. Using abdominal adipose tissue expression data of the chickens, 198 candidate genes were expressed with 11 differentially expressed genes (DEGs) in fat vs. lean lines identified. Amongst the DEGs, VCAN was related to fat metabolism. GO pathway enrichment analysis and QTL annotations were performed to fully characterize the selection mechanism(s) of chicken abdominal fat content. Conclusions: We have found some selection regions and candidate genes involving in fat metabolism on the Z chromosome. These findings enhance our understanding of sex chromosome selection signals.
Design of An Ultra-Thin and Broadband Absorption Materials For Middle-Temperature Applications
Authors: Jia Yanmin , Yang Zhaoning , Gao Lu , Ren Wei , Zhang Ruiduan , Zhou Qian , Li Weijun , Chen Yangyang , Zhang Yunguang , Sun Kai , Jie Ziqi 
Published: February 2021

Abstract
A radar absorbing material (RAM) is designed based on the magnetic ceramic and frequency selective surface (FSS). The phase composition and micromorphology were characterized, respectively. The complex permittivity and complex permeability of magnetic ceramic were tested and studied from 25 ℃ to 500 ℃ temperature. Based on the experimental and simulation results, the changes of reflection loss along with the structure parameters of RAM are analyzed at 500 ℃. The relationship of reflection loss varies with temperature are studied. The analytical results show that the absorption property of the RAM increases with the increase of temperature. An optimal absorption of RAM is obtained at 500℃. When the thickness of RAM is 1.5 mm, the reflection loss lower than -10 dB can be obtained in the frequency range from 8.2 ~ 16 GHz. More than 90% microwave energy can be consumed in the RAM which may be applied in the high temperature environment.
Real-World Data Analysis of Healthcare Resource and Cost Utilization From Non-Alcoholic Fatty Liver Disease Patients in Japan
Authors: Hasegawa Ken , Aruga Atsushi 
Published: February 2021

Abstract
Background: Demographic, healthcare resource utilization (HCRU), and healthcare costs of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) patients, and those progressed to liver cirrhosis (LC) and hepatocellular carcinoma (HCC) was assessed from Japan Medical Data Center (JMDC) claims database. Methods: 185,012 NAFLD or NASH patients between 1st January 2006 and 31st July 2018 were identified from JMDC database. Mean annual all-cause HCRU and costs were reported pre- and post-index date of the initial diagnosis of NAFLD/NASH, LC and HCC. Age, gender, and comorbidity influence on post-index cost was assessed with a multivariable analysis. Results: 123,379 NAFLD/NASH, 205 LC, and 96 HCC patients were selected into 3 liver severity cohorts based on the study inclusion/exclusion criteria. Majority of patients were male (70.0% to 71.7%) with comorbid hyperlipidaemia (50.2% to 61.5%), diabetes mellitus (40.0% to 60.4%), and hypertension (27.9 % to 42.7%) most prevalent across the 3 liver disease states. The mean all-cause healthcare annual cost significantly increased with liver disease severity, at ¥146,096, ¥399,425 and ¥842,875 for NAFLD/NASH, LC and HCC patients, respectively. Comorbid cardiovascular disease (CVD), following by type 2 diabetes mellitus (T2DM) had the highest influence on all-cause cost with a cost ratio of 1.77 and 1.45, respectively. Conclusions: NAFLD/NASH patients with LC or HCC have increased comorbidity burden, high HCRU, and healthcare costs, which further highlights the importance and need of timely identification and management for NAFLD and NASH patients in Japan.
Abnormal Expression of the Steroid Hormone Synthesis Pathway Associates with Cattle Ovarian Cysts
Authors: Xu Xiaoling , Bai Jiahua , Qin Yusheng , Feng Tao , Xiao Linli , Song Yuqing , Yang Ting , Liu Yan 
Published: February 2021

Abstract
BackgroundWhen a mature follicle fails to ovulate, ovarian cysts can develop and persist in the ovary, interfering with normal ovarian functions. However, the etiology of ovarian cysts remains poorly understood.ResultsBy enzyme-linked immunosorbent assay (ELISA) of the bovine follicle fluid from cystic follicles , we found that cystic follicles were characterized by lower oestradiol (E2), Insulin-like growth factor 1(IGF1), and insulin levels but elevated progesterone (P4) compared with preovulatory follicles (p <0.05). Further gene expression profiling of follicle walls by RNA sequencing (RNA-seq) showed that there are 356 differentially expressed genes between preovulatory follicles and corpus luteum cyst groups, and 582 differentially expressed genes between preovulatory follicles and follicular cyst groups. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis linked steroid hormone synthesis pathway to the formation of ovarian cysts, and steroidogenic acute regulatory protein (STAR), cytochrome P450, family 11, subfamily A, polypeptide 1 (CYP11A1), hydroxy-delta-5-steroid dehydrogenase, 3-beta- and steroid delta-isomerase 1 (HSD3B1), cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1), and cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) genes in the steroid hormone synthesis pathway play important roles in this process. ConclusionsAbnormal hormone profiles and expression of steroid hormone synthesis pathway genes related to the formation of ovarian cysts. The findings lay a theoretical foundation for the prevention and treatment of ovarian cysts.
A New Microfluidic Concept for Successful in Vitro Culture of Mouse Embryos
Authors: Mancini Vanessa , McKeegan Paul , Schrimpe-Rutledge Alexandra C. , Codreanu Simona Gabriela , Sherrod Stacy D. , McLean John A. , Picton Helen M. , Pensabene Virginia 
Published: February 2021

Abstract
Innovative techniques for gene editing have enabled accurate animal models of human diseases to be established. In order for these methods to be successfully adopted in the scientific community, the optimization of procedures used for breeding genetically altered mice is required. Among these, the in vitro fertilization (IVF) procedure is still suboptimal and the culture methods do not guarantee the development of competent embryos. Critical aspects in traditional in vitro embryo culture protocols include the use of mineral oil and the stress induced by repetitive handling of the embryos. A novel microfluidic system was designed and fabricated in poly dimethyl siloxane (PDMS) to allow for efficient in vitro production of mouse embryos. Culture experiments conducted by completing the industry gold standard Mouse Embryo Assay excluded any harmful fluidic stress and plastic toxicity. The developmental competence of the embryos developed in the device was consistently confirmed by high blastocyst rate (>80%), hatching and outgrowth rate, and matched with analysis of energy substrate metabolism and expression of genes related to implantation potential. Metabolomics analyses of spent culture media allowed for biologically important metabolite changes to be observed throughout embryo development, and for identification of specific overrepresented metabolic pathways affected by the microfluidic environment. Moreover, mass spectrometry data identified plastic-related compounds released in medium, and confirmed leaching of low molecular weight species into the culture medium that might be associated to un-crosslinked PDMS. Finally, these data show the potential for the system to study preimplantation embryo development and to improve the embryo culture techniques used for human assisted conception.
Characterization and Optical Gas Sensing Properties of BaSnO3 Synthesized By Novel Technique: Flame Spray Pyrolysis
Authors: ONGUN Merve ZEYREK , OGUZLAR Sibel , Akalin Alper S. , Yildirim Serdar 
Published: February 2021

Abstract
Barium stannate (BaSnO3) particles were synthesized using a one-step flame spray pyrolysis (FSP) method. The fabricated ceramic powders were investigated in terms of the structural, morphological, and optical properties by using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), X-Ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), zeta particle size analyzer, UV-visible spectroscopy (UV-vis) and photoluminescence spectroscopy (PL). The XRD results showed the structure of BaSnO3 crystals have been obtained when the powders were exposed at high temperature, specifically at 1200 °C. The synthesized particles in the submicron size in a range of 70-980 nm were produced. The optical band gap value of the synthesized crystals was calculated by means of reflectance spectra with the Kubelka-Munk method and found as 3.14 eV. When the powders excited at 375 nm, they exhibited emission bands in the visible and near-infrared region (NIR) of the electromagnetic spectrum. As far as we know, this is the first time BaSnO3 crystals have been synthesized using the FSP technique. In this study, the intensity- and decay time- based gas sensing properties of BaSnO3 embedded in ethyl cellulose thin films when exposed to the vapors of ethanol, acetone, and ammonia were also measured.