bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 Protective Behaviors among Iran’s Health System Workers: Psychological Theoretic Design Analysis
Authors: Ghobadi Kamel , Rakhshanderou Sakineh , Hossaini Fatemeh , Ghaffari Mohtasham 
Published: February 2021

Abstract
Background & Aim: Health system staff is as first front line to combat corona disease, and probability of risk of infection to COVID-19 are more in them. This study aimed to investigate protective behaviors related to COVID-19 in Iranian health system staff using a psychological theoretical framework - EPPM (Extended Parallel Process Model) case.Methods: The current study was in cross-sectional design and performed online from May 4 to July 22, 2020 on 418 individuals selected from Iranian health system staff including (physician, nurse & laboratory technician, health worker, administrative staff, radiologist). Data was gathered using valid and reliable electronic questionnaire designed based on EPPM which assesses relations of constructs (perceived susceptibility, perceived severity, perceived self-efficacy, and perceived response-efficacy) with the intention and performing protective behaviors) and published through Porsline site. Data was analyzed using descriptive statistics, t–test, analysis of variance, and regression in SPSS software version 16.Results: Most individuals (40.4%) were in age group of 30-40, which (72%) were married and majority of them was woman (70.6%). Pearson correlation test showed significant association among performing protective behaviors and constructs of perceived self-efficacy (r=0.373, P=0.000), perceived response-efficacy (r=0.120, P=0.014), and intention (r=0.462, P=0.000). Multiple regression analysis recognizes perceived self-efficacy (P=0.000; Beta=0.398), and behavioral intention (P=0.000; Beta=0.283) as predictors of performing protective behaviors. Results of descriptive statistical analysis in order to determine critical point based on EPPM showed that 35.4% of health system staff with critical point lesser than 1, were in fear control process and 34.4% of individuals with critical point more than 1 are involved in danger control process.Conclusion: Only, one third of health system staff is involved in process of controlling risk of COVID19. Motivation of protection in health system staff is established in case of perception self-efficacy as well as perception efficacy on COVID-19 preventive behaviors. Therefore, programming to perform interventions based on EPPM by emphasis on strategies of promoting perceived self-efficacy and perceived response-efficacy in order to improve performing protective behaviors in this highly vulnerable subgroup is seriously recommended.
CPAP as a useful tool in COVID-19 related Acute Hypoxemic Respiratory Failure: Experience from 3 UK Hospitals
Authors: Ahmed Yasser Noeman , Setty Niranjan , Roshdy Ashraf , Powrie Duncan J , Amran Dora A , Elsheikh Alguili , Gokaraju Sriya , Tear Anne , Noeman Maryam , Darda Maria , Sayed Iman El , Karunanithi Vijayalakshmi , Aarani Mahalingam , Shafiq Muhammad , Abdul-Khaliq  , Samuel Johnson 
Published: February 2021

Abstract
Introduction: Severe acute hypoxemic respiratory failure (AHRF) in COVID-19 pneumonia is associated with a high mortality rate, resulting in mounting pressures on intensive care units worldwide. Different oxygenation management protocols are used in different centres. Most centres switch patients who fail to oxygenate adequately using conventional oxygen therapy (COT) methods to non-invasive positive pressure ventilation (NIPPV), usually continuous positive airway pressure (CPAP). Other centres resort to invasive mechanical ventilation (IMV) directly, without a trial of NIPPV. In this trial, we aim to compare the efficacy of different approaches in managing COVID-related AHRF, and ascertain if CPAP therapy reduces the need for IMV. Methods: We carried out a retrospective cohort study on patients with laboratory-confirmed COVID-19 at three university hospitals in Essex, United Kingdom. We included all patients with significant AHRF (defined as needing oxygen therapy FiO2 more than 0.4 to maintain an oxygen saturation of 92%) who were deemed eligible for IMV escalation during a 3-month period (1st March to 31st May 2020).Results: Out of 174 patients who met the criteria, 84 patients received CPAP (Group 1). Half needed intubation (n=42). 90 patients did not have a CPAP trial (Group 2). 76.6% needed intubation (n=69). No difference was found between the two groups in demographic criteria or disease severity. Our results show a significant difference in 60-day mortality between group 1 and 2 (25% versus 37.8%, p=0.02). COT as standalone therapy for COVID-19 patients (group 2) was associated with a trend of more increased risk of intubation and an increased relative risk of death (RR 2.14, 95% CI 1.39 to 3.29). This corresponds to a number needed to treat (NNT) of 3.74 (95% CI 2.47 to 7.73). Patients in group 1 who failed CPAP trial and required intubation did not have an increased risk of mortality when compared to group 2 patients who required intubation.Conclusion: Our results support introducing CPAP rather than escalating FiO2 in cases refractory to COT. Our study suggests CPAP can be safely used to treat patients with AHRF. Clinical trials are needed to guide recommendations for optimum timing and selection of patients most likely to benefit.
The possibility of care engineering to enhance STEAM education in future care through the title analysis
Authors: Fujii Chieko , Ohnishi Kengo , Kajitani Isamu , Homma Keiko , Yoshikawa Masahiro 
Published: February 2021

Abstract
Background

It is necessary to systematise care engineering to solve the social issues related to care in STEAM (Science, Technology, Engineering, Art and Mathematics) education. While the need for engineering and technology in care has increased, current trends are not well understood. This search was conducted using Web of Science, a literature database, with the study period spanning 1900 to 2019. The search term ‘care’ was used, as well as ‘Science’, ‘Technology’, ‘Engineering’, ‘Art’, or ‘Mathematics’. Subsequently, the research field from the Web of Science was extracted every 10 years, from 1980 to 2019. The ‘title’ as selected by the Web of Science was analysed using KH Coder 3.Beta.01e analysis software, with frequent nouns, adjectives, verbs, and adverbs examined.
Results

The most frequently used words were extracted using KH Coder. Of the highest ranked words, ‘children’ was ranked high until 1969; ‘health’, ‘medical’, and ‘cost’ were ranked high in the 1970s; and ‘system’, ‘information’, ‘assessment’, and ‘primary’ were highest in the 1980s, 1990s, 2000s, and 2010s, respectively. Healthcare has always been the most qualified language, and especially in the 1990s, when it accounted for 59.1%. More frequently occurring in the 1980s, 1990s, 2000s, and 2010s were ‘home care’; ‘critical’ or intensive’; ‘patients’ or ‘primary care’; and ‘self’, ‘quality’ or ‘palliative care’, respectively. The co-occurring network diagram most often categorised ‘quality support’, ‘care engineering’, ‘primary’ and ‘intervention’, ‘medical care’, ‘human development’, ‘lifestyle’, and ‘social’ issues.
Conclusion

The use of technology is expected to advance, and research on improving the quality of care is expected to increase. Systematising this as ‘care engineering’ creates a field to face the long-term problems in care. Literature on human development and the quality of care itself are expected to evolve, and new developments should occur from the care perspective.
Unpacking the policy landscape for implementing an Information Communication Technology (ICT) based in Human Resources Management tool in government health sector in Bangladesh: Findings from a policy review
Authors: Bhattacharyya Dipika Shankar , Dutta Goutam Kumar , Nowrin Iffat , Shafique Sohana , Islam Md. Zahidul , Islam B. M. Riazul , Anwar Iqbal 
Published: February 2021

Abstract
Introduction: In Bangladesh, to address the challenges of ensuring adequate human resources for health (HRH), the government began implementing a digital tool for HRH management in 2017. However, evidence suggests institutionalizing such tools in low-and-middle-income-countries are impeded by policy aspects like implementation strategy and poor regulatory framework. We aimed to explore factors in the current policy landscape that might facilitate and challenge the implementation of the tool in Bangladesh.Methods: We conducted a review of policies related to ICT implementation and human resources management in health sector in Bangladesh using qualitative content analysis method. Twelve policies have been identified and comprehensive reading was done to ascertain common themes and patterns. A document analysis matrix was developed to synthesize and help interpreting the findings. Results: Regarding facilitators, strong upstream level commitments were reflected in the content of policies in terms of setting out specific objectives, targets, timeline, and budget allocation. However, lack of explicit monitoring strategy and extent of stakeholders’ engagement was not well-defined, ultimately create chances for making downstream implementation disjointed. In addition, effective coordination among stakeholders and different HRH and ICT policies could be strengthened. Discussion: Findings support the current discourse that national commitment plays a vital role in integration of ICTs in health services. However, well-defined monitoring strategy and inter-ministry and intra-ministry policy coordination is crucial.
Screw thermal characteristics analysis and error prediction considering the two-dimensional heat transfer structure
Authors: Chen Yu , Chen Jihong , xu guangda 
Published: February 2021

Abstract
Thermal error is a common problem in machine tool processing. It is usually proposed to take the screw as one-dimensional rod heat transfer system to solve the thermal error of screw by establishing thermal characteristic equation. This method regards the temperature on the nut as the temperature of the screw contact surface without considering the heat transfer distance between screw and the mounting point on the nut. To solve this problem, this paper takes the screw-nut feed system as a two-dimensional heat transfer structure considering both screw and nut. In addition, to solve the low convergence speed and easy fall into local optimum problem in optimal parameter identification. The improved particle swarm optimization algorithm (IPSOA) is proposed to identify the boundary parameters of thermal characteristics equations. Finally, the temperature and thermal error of the screw-nut feed system is calculated by the identified results. Experiments under different working condition show that the maximum prediction residual error of the two-dimensional method (TDM) is less than 7.2 um and the simulating prediction accuracy can reach 86.2%. Besides, compared with one-dimensional model (ODM), TDM has a higher predict accuracy which verifies the effectiveness of the proposed method.
Protein interface redesign facilitates conversion of zero-dimensional protein nanomaterials to their one- and two-dimensional analogues
Authors: Zhang Xiaorong , Liu Yu , Zheng Bowen , Zang Jiachen , Lv Chenyan , Zhang Tuo , Wang Hongfei , Zhao Guanghua 
Published: February 2021

Abstract
Although various artificial protein nanoarchitectures have been constructed, controlling conversion between protein assemblies with different dimensions has largely been unexplored. Here, we describe a simple, effective approach to regulate conversion between 0D protein nanomaterials and their 1D or 2D analogues by adjusting the geometric arrangement of dimeric protein building blocks. Thermotoga maritima ferritin (TmFtn) naturally occurs as a dimeric protein, twelve of which interact with each other in a head-to-side manner to generate 0D 24-meric protein nanocage in the presence of Ca2+. By tuning two contiguous dimeric proteins to interact in a fully or partially side-by-side fashion through protein interface redesign, we can render the conversion of the inherent salt-mediated 0D protein nanocage into 1D or 2D nanomaterials in response to multiple external stimuli. Thus, one kind of dimeric protein building block can generate three protein materials with different dimensions in a manner that highly resembles natural pentamer building blocks from viral capsids that form different protein assemblies.
Numerical and Experimental Study on Microstructure Evolution of Ti-6Al-4V Alloy Shaft Perform in Cross-Wedge Rolling Process
Authors: Yuan Jiayao , Chen Xing , Zhao Zhilong , Sun Baoshou , Shu Xuedao 
Published: February 2021

Abstract
To seek a fundamental understanding for further improving the Ti-6Al-4V alloy utilization of Cross-Wedge Rolling (CWR) and the comprehensive mechanical properties of shaft parts, the effect of the CWR processing parameters on the microstructure evolution of Ti-6Al-4V alloy shaft preform is studied in this paper. An Arrhenius-type microstructure structure evolution model was employed and implemented into the finite element software DEFORM-3D. The average grain size and dynamic re-crystallization volume fraction distribution in the α+β two-phase region and the β single phase region under different rolling temperature, roller rotating speed and area reduction were analyzed, respectively. It is finding that the area reduction, rolling temperature and roller rotating speed significantly affect the microstructure evolution of Ti-6Al-4V alloy. Meanwhile, the corresponding CWR and Metallographic experiments were conducted to verify the reliability of the FE simulation results. Results showed that the agreement of the process parameters effect on dynamic recrystallization in the α+β two-phase region between simulation and experimental is reasonably good. The difference in average grain size in the β phase region between simulation and experimental is ranged from 5.77% to 18.56%. In addition, the evenly distributed microstructure can be found as the area reduction of 50%, rolling temperature of 950℃ and the speed of 5 r⋅min−1 were employed. After rolling under optimized processing conditions, the tensile strength of Ti-6Al-4V alloy shaft preform increased by 18.57% and the plasticity enhanced significantly due to smaller grain size and bi-model microstructure obtained.
Medicine Facing Death: Attitudes Toward Physician-Assisted End of Life – A Cross-Sectional Study
Authors: Dopelt Keren , Cohen Dganit , Amar-Krispel Einat , Davidovitch  , Barach Paul 
Published: February 2021

Abstract
Background: The demand for medical assistance in dying remains high and controversial. The "Dying Patient Act" (2005) legalized requiring Israeli patients to receive medical guidance regarding the care (or non-treatment) they seek at the end of life. Many doctors have made it clear that helping a patient die is opposed by their values and professional goals.Objective: To explore the attitudes of physicians regarding euthanasia and examine the factors that related to these attitudes.Methods: We conducted a cross sectional prospective study in Israel, during January-February 2019. We used logistic regression analyses to describe the association of demographic and professional factors with attitudes toward physician-assisted end of life.Results: We surveyed 135 physicians working at a tertiary-care-hospital about their attitudes regarding euthanasia. About 61% agreed that a person has the right to decide whether to expedite their own death, 54% agreed that euthanasia should be allowed, while 29% thought that physicians should preserve a patient's life even if they expressed the wish to die. Conclusion: The data shows a conflict of values: the sacredness of human life versus the desire to alleviate patient's suffering. Coronavirus outbreak reinforces the urgency of our findings and raises the importance of supporting physicians' efforts to provide ethical, and empathic communication for terminally ill patients. Future studies should aim to improve our understanding and treatment of the specific types of suffering that lead to end-of-life requests.
Endotracheal Intubation in Patients With COVID-19 By Emergency Physicians in The Tokyo Metropolitan Area
Authors: Soh Mitsuhito , Hifumi Toru , Otani Norio , Miyazaki Momoyo , Kobayashi Kentaro , Maki Kenro , Hayashi Munehiro , Hatakeyama Junji , Kurihara Tomohiro , Ishimatsu Shinichi 
Published: February 2021

Abstract
Background: Patients with COVID-19 may require emergency tracheal intubation for mechanical ventilation by emergency physicians. However, the success rate, complications, operator safety, and issues around personal protective equipment (PPE) and barrier enclosure use are not known in this context.Methods: This was a retrospective study of data for adult patients with COVID-19 who underwent endotracheal intubation performed by emergency physicians at four hospitals in the Tokyo Metropolitan Area between January 2020 and September 2020. Patient characteristics, intubation-related factors, and intubation success and complications rates were obtained. Two analyses were then performed. In analysis 1, the intubation success rate in patients was compared among four groups using different types of PPE. In analysis 2, patients were compared by those intubated with or without barrier enclosure.Results: In total, 46 patients met the inclusion criteria, of whom 85% were successfully intubated at the first attempt, 27% experienced hypotension, and 27% experienced hypoxia. No muscle relaxants were used in 8.7% and the Macintosh blade was used in 37%. The four PPE types and the intubation confirmation methods varied considerably, but all met the WHO recommendations. A barrier enclosure device was used in 26%, with a success rate of approximately 80% irrespective of its use.Conclusions: The success rate at the first attempt of intubation was relatively high, albeit with a moderately high complication rate. All PPE types were safe, including when barrier enclosures were used. Success was not affected by using barrier enclosures.
Berberine Interferes With the Abnormal Glomerular Mesangial Cell C Ycle Re-Distribution to Alleviate Diabetic Nephropathy via PI3K/AKT/AS160/GLUT4 Signaling Pathway
Authors: Guan Ximei , Ni Weijian , Zeng Jing , Zhou Hong , Tang Linqin 
Published: February 2021

Abstract
Background: Berberine plays a critical role of the glomerular mesangial cells (GMCs) abnormal proliferation during diabetic nephropathy (DN). This study aims to explore the intervention effect of BBR on DN mice and investigate the potential mechanism targeting abnormal GMCs proliferation. Methods: Streptozotocin-induced mice were used to determine the effect of BBR on the renal injury. In vitro, GMCs are cultured in high glucose (30 mmol/L). EdU and MTT assay are used for screening the optimum BBR concentration and intervention time. Flow cytometry is applied to analyze the cell cycle re-distribution. Western blot and RT-qPCR are devoted to studying the relative expression of molecules in PI3K/AKT/AS160/GLUT4 signaling pathway. Additionally, 2-NBDG assay is selected for measuring the glucose uptake of GMCs. Results: HE and PAS staining revealed that the notable mesangial matrix expansion, glomerular hypertrophy and glycogen deposition in diabetic kidney can be alleviated after BBR treatment. Moreover, BBR significantly reduced the positive expression of GLUT4 in tubulointerstitium and glomerular region. EdU shows that high glucose induces the abnormal proliferation of GMCs, which becomes more apparently as time goes on (20h→28h). Meantime, BBR (60 and 90 μmol/L) can not only increase the proportion of G1 phase, but also reduce the proportion of S phase. After 24 h, the same sort of phenomenon has cropped up in BBR (30 μmol/L) group. BBR (60 μmol/L)) significantly degraded the levels of PI3K-p85, p-AKT, p-AS160, and the membrane-GLUT4, while indistinguishable changes of their total protein expressions. Additionally, BBR prominently reduced the glucose uptake and retard the cell cycle of GMCs to stay at G1 phase. Conclusions: The rearrangement effect of BBR on cell cycle is related with PI3K/AKT signaling pathway and GLUT4 trafficking. The key findings of our study collectively indicate that the treatment of GMCs proliferation can be a novel therapeutic strategy in DN.
Route Towards Efficient Magnetization Reversal Driven by Voltage Control of Magnetic Anisotropy
Authors: One Roxana-Alina , Béa Hélène , Mican Sever , Joldos Marius , Brandao Pedro Veiga , Dieny Bernard , Buda-Prejbeanu Liliana D. , TIUSAN Coriolan 
Published: February 2021

Abstract
The voltage controlled magnetic anisotropy (VCMA) becomes a subject of major interest for spintronics due to its promising potential outcome: fast magnetization manipulation in magnetoresistive random access memories with enhanced storage density and very low power consumption. Using a macrospin approach, we carried out a thorough analysis of the role of the VCMA on the magnetization dynamics of nanostructures with out-of-plane magnetic anisotropy. Diagrams of the magnetization switching have been computed depending on the material and experiment parameters (surface anisotropy, Gilbert damping, duration/amplitude of electric and magnetic field pulses) thus allowing predictive sets of parameters for optimum switching experiments. Two characteristic times of the trajectory of the magnetization were analyzed analytically and numerically setting a lower limit for the duration of the pulses. An interesting switching regime has been identified where the precessional reversal of magnetization does not depend on the voltage pulse duration. This represents a promising path for the magnetization control by VCMA with enhanced versatility.
Preparation and Characterization of CuO/Co3O4/ Poly(Methyl Methacrylate) Nanocomposites Films for Optical and Dielectric Applications
Authors: El-Sayed S. , Sayed Adel El 
Published: February 2021

Abstract
Composites of transition metal oxides (TMOs)/Polymers have many modern technological, industrial, and biological applications. Co3O4 and CuO nanoparticles (Nps) were synthesized by sol-gel. Then they doped into poly(methyl methacrylate) (PMMA) via solution casting method. The obtained Nps and nanocomposite films were then investigated using several techniques. XRD and HR-TEM indicated the high purity of Co3O4 and CuO Nps of face-centered cubic (fcc) with 58 nm average particle size (Dav), and monoclinic structure with Dav = 35 nm, respectively. The amorphous nature of PMMA was influenced after mixing with these Nps. SEM and FTIR confirmed the interaction between Nps and the polymer chains. The pure film showed transparency of about 90% and Nps addition narrowed the optical bandgap effectively while keeping the films with high transmittance. CuO is more effective than Co3O4 on the optical parameters of the films. The dielectric constant improved after adding the Nps, while all films have a low dielectric loss. Additionally, the effects of Co3O4 and CuO on the ac conductivity, Argand plots, and the dielectric modulus are reported. Our nanocomposites are considered a promising candidate for nanotechnology-based devices such as electric stress control, film capacitors and anti-reflective coating for solar cell applications.