bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of infusion frequency on quality of life in patients receiving home parenteral nutrition
Authors: Stanner Heather , Zelig Rena , Rigassio Radler Diane 
Published: December 2021

AbstractHome parenteral nutrition (HPN) may be needed as a long‐term therapy for patients with chronic intestinal failure whose clinical condition does not allow complete weaning of the parenteral nutrition (PN) solution. HPN is a time‐consuming and clinically complex therapy and can negatively affect quality of life (QOL). The level of dependency on HPN, specifically, infusion frequency, has been proposed as a factor that may have an effect on QOL in patients receiving HPN. The primary aim of this qualitative review is to identify the impact of HPN frequency (days per week of HPN infusion) on QOL measurements in adult patients receiving HPN. A comprehensive literature search was completed in PubMed and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases. Primary clinical research studies were included if they were conducted in adult patients receiving HPN and included the assessment of the associations between the frequency of HPN infusion and QOL measurements. Six articles ultimately met the criteria for this review. There was variability among the studies, including use of different tools to measure QOL. However, all six studies suggest that a reduction in HPN frequency may be associated with an improvement in QOL. Whenever patients’ clinical situation allows, a reduction in HPN frequency should be considered to improve QOL in patients receiving HPN.
A Facile and Flexible Humidity Sensor Based on Porous PDMS/AgNWs and GO for Environmental Humidity and Respiratory Detection
Authors: Ma Yanming , Hu Xinqiang , Li Shunbo , He Ye , Xia Zengzilu , Cai Kaiyong 
Published: December 2021

AbstractHumidity sensors, benefit from their superior humidity‐sensitive components, are able to respond to the environment moisture changes. Based on this feature, the humidity sensor plays an increasingly vital role in biological detection. To improve the performance of humidity sensors, a large number of optimizations have been made from several aspects, such as material synthesis and structural design. In this study, a novel humidity sensor is designed to increase its specific surface area to carry more humidity‐sensitive and conductive materials. A porous polydimethylsiloxane (PDMS) substrate is prepared in an economical friendly approach by using the thermal decomposition of sodium bicarbonate (NaHCO3). Meanwhile, high‐quality nano silvers (AgNWs) are applied as the intermediate conductive layer connecting the substrate and detective layer. graphene oxide (GO) is used as the humidity sensitive material in the sensor. It is remarkable that this sensor can detect the humidity with a wide range of 8.6 RH% to 93 RH% in a quick response with high sensitivity. Since this humidity sensor showed powerful functions, such as monitoring respiration and detecting environmental humidity, it will have broad potentials for real‐time clinical and domestic healthcare.
Synthesis and Luminescence Study of n‐UV Excitable Tm3+‐Activated Blue Phosphor
Authors: Taikar Deepak R. , Taikar Ramesh N. , Nagde Kalpana R. , Sarve Sadanand R. 
Published: December 2021

AbstractTm3+‐doped La2O3 phosphors with different doping concentration are prepared by co‐precipitation method. The prepared phosphor is characterized by X‐ray powder diffraction (XRD), SEM, Fourier transform infrared (FT‐IR) spectroscopy, and photoluminescence (PL) techniques. The XRD analysis confirms the formation of La2O3. PL measurement shows that the phosphor exhibit characteristic Tm3+ bright blue emission attributed to transition from 1D2 → 3F4 of Tm3+ ions, at 363 nm excitation. The Commission International de I'Eclairage (CIE) chromaticity color coordinates of prepared phosphor is calculated and presented. The excitation peak located at 363 nm matches with the emission wavelength of near UV‐LED chip, this indicates that the prepared phosphor is a promising blue light‐emitting candidate for eco‐friendly solid state lighting (W‐LED) application.
Octadecyltrichlorosilane‐Modified Superhydrophobic‐Superoleophilic Stainless Steel Mesh for Oil‐Water Separation
Authors: Sutar Rajaram S. , Kulkarni Narayan P. , Nagappan Saravanan , Jundle Akshay R. , Pawar P. G. , Pargaonkar Nikhil N. , Gharge Nilam B. , Yadav Prashant S. , Kshirsagar Shrutika S. , Kanchankoti Susmita S. , Sawant Akshata S. , Kodag Snehal G. , Mahajan S. S. , Shinde V. S. , Park Kang Hyun , Sadasivuni Kishor Kumar , Bhosale Appasaheb K. , Latthe Sanjay S. 
Published: December 2021

AbstractRecently, oil‐water separation has become an important topic due to its increasing commercial demand. Here, in this study, a simple technique to prepare superhydrophobic‐superoleophilic mesh for oil‐water separation is reported. The pre‐cleaned stainless steel mesh is modified by octadecyltrichlorosilane (ODS) through solution immersion method. The modified mesh shows the water contact angle (WCA) of 158 ± 2° and oil contact angle (OCA) of 0°. The prepared superhydrophobic‐superoleophilic mesh effectively separates various oils, including petrol, kerosene, diesel, vegetable oil, and coconut oil from oil–water mixtures with separation efficiency greater than 95%, and stable recyclability up to 10 cycles. In case of low viscosity oil (petrol), the modified mesh shows permeation flux of 2086.95 ± 104.34 L/(m2.h), which is higher than high viscosity oils.
Studies on Structural Properties of Ytterbium (Yb3+) Substituted Mg–Cu–Zn Nano‐ferrites
Authors: Patil Prakash S. , Pawar Amol D. , Patil Bajrang B. , More Leena S. , Bhosale Dheeraj B. , Barate Shruti S. , Ghodake Jeevan S. , Thorat Jayavant B. , Shinde Tukaram J. 
Published: December 2021

AbstractNano‐ferrites with composition Mg0.55Cu0.05Zn0.4YbxFe2‐xO4 (where x = 0.0, 0.01, 0.02, and 0.03) are prepared by chemical method. The single‐phase cubic spinel structure ferrite formation is confirmed from X‐ray diffraction (XRD) analysis. The lattice constant and crystallite size of Mg–Cu–Zn ferrites found to be decreases with increasing concentration of Yb3+ content. The two major absorption bands appear in the range 432.16–441.55 cm–1 and 568.25–578.56 cm–1 corresponding to octahedral and tetrahedral sites in the Fourier transform infrared (FTIR) spectra suggest formation of ferrites. Morphological study shows the formation of nano‐ferrites. The EDX analysis approves the formation of required ferrites in desired stoichiometric ratio without any impurity phase.
Hydroxyapatite‐Graphene Oxide Nanocomposite with Enhanced Ammonia Sensing Property
Authors: Begum Sumayya , Narwade Vijakirany N. , Taha Sabah , Mahabole Megha P. , Dadge Jagdish W. , Bogle Kashinath A. 
Published: December 2021

AbstractThis study is focused on presenting a new approach for utilizing properties of hydroxyapatite (HAp) and carbon‐containing material in sensing applications. Nanocrystalline HAp and graphene oxide (GO) are synthesized by wet chemical precipitation and Hummer's method, respectively. A nanocomposite based on HAp and 2 wt % concentration of GO is prepared just by a mechanically mixing method. A simple and cost‐effective screen printing technique is utilized for the development of thick films on a glass substrate. The ammonia‐sensing properties of the nanocrystalline material HAp and 2 wt% GO‐doped HAp are investigated by two‐probe electric method. The gas‐sensing parameters like operating temperature, response/recovery time, maximum detection limit, etc., are studied. The best sensing performance is shown by 2 wt% GO doped HAp thick film for the detection of 10 ppm of ammonia at 35 °C, i.e., its operating temperature than the pure HAp. The maximum uptake capacity of ammonia for 2 wt% GO doped HAp is found to be very high, i.e., 2000 ppm compared to the pure HAp, i.e., 1200 ppm. Whereas other parameters like response and recovery time at corresponding operating temperatures are nearly the same for both sensing substrates.
Room Temperature Surface Oxidation by Alkalization of Binder Free CuO Nanostructured Electrode for Enhanced Supercapacitive Performance
Authors: Pawale Rohan S. , Yadav Suhasini J. , Salokhe Balaji S. , More Suraj M. , Patil Sharad B. , Kim Jin H. , Gurav Kishor V. 
Published: December 2021

AbstractThe copper oxide (CuO) nanostructures are synthesized via facile oxidation of Cu foil in an aqueous KOH solution at room temperature. A precleaned Cu foil immersed in a 0.1 M aqueous KOH solution for different time periods (36–72 h) systematically converts its surface into nanochained to rice husk morphology and then agglomerated dense nanoclusters. The impact of immersion time on the morphology and consequently supercapacitor performance is studied. The CuO nanostructure synthesized at an immersion time of 60 h shows a maximum specific capacitance of 302 Fg–1 at a scan rate of 2 mV s−1. The capacitance retention reaches up to 87% after 2000 cycles.
Effects of Electrolyte Composition on the Supercapacitive Performance of Chemically Synthesized Bundles of Stacked Cu(OH)2 Nanosheets
Authors: Salokhe Balaji S. , Gonugade Madhuri D. , More Suraj M. , Bobhate Pradip A. , Gurav Rutuja N. , Patil Umakant M. , Kim Jin Hyeok , Gurav Kishor. V. 
Published: December 2021

AbstractThe electrochemical performance of an electrode in a supercapacitor primarily depends on the electrolyte composition. Herein, the effect of electrolyte composition on the electrode performance of copper hydroxide [Cu(OH)2] nanosheets thin film is investigated. Cu(OH)2 nanosheets thin film is synthesized by facile chemical bath deposition (CBD) method. The structural and morphological properties are investigated by X‐ray diffraction (XRD) and scanning electron microscopy (SEM). The pure phase Cu(OH)2 nanosheet thin film is effectively used as an electrode for supercapacitor. The electrochemical performance of Cu(OH)2 nanosheets thin film is investigated using various 1 M aqueous electrolytes such as KOH, NaOH, and Na2SO4. Among all other electrolytes, Cu(OH)2 nanosheets thin film shows the highest specific capacitance of 467 Fg–1 at a scan rate of 5 mV s–1 in 1 M KOH. Further, cyclic stability for 2000 cycles shows capacitance retention of 93%.
Role of solute carrier transporters SLC25A17 and SLC27A6 in acquired resistance to enzalutamide in castration‐resistant prostate cancer
Authors: Kushwaha Prem P. , Verma Shiv S. , Shankar Eswar , Lin Spencer , Gupta Sanjay 
Published: December 2021

AbstractEnzalutamide (XTANDI®), an antiandrogen, is used for the treatment of advanced‐stage prostate cancer. Approximately, 60% of patients receiving enzalutamide show initial remission followed by disease relapse with the emergence of highly aggressive castration‐resistant prostate cancer. Solute carrier (SLC) proteins play a critical role in the development of drug resistance by altering cellular metabolism. Transcriptome analysis revealed the predominance of SLC25A17 and SLC27A6 in enzalutamide‐resistant prostate cancer cells; however, their role in antiandrogen resistance has not been elucidated. sgRNA‐mediated knockdown of SLC25A17 and SLC27A6 suppressed cell proliferation and migration in enzalutamide‐resistant cells. An induction of G1/S cell cycle arrest and abundance of hypo‐diploid cells along with the reduction in the protein expression CyclinD1 and CDK6, the checkpoint factors, was observed including increased cell death as evident by BAX upregulation in knockdown cells. Inhibition of SLC25A17 and SLC27A6 resulted in downregulation of fatty acid synthase and acetyl‐CoA carboxylase with parallel decrease in the levels of lactic acid in enzalutamide resistant cells. However, downregulation of triglyceride and citric acid was only observed in SLC25A17 silenced cells. The protein–protein interaction of SLC25A17 and SLC27A6 revealed alteration in some common drug‐resistant and metabolism‐related genes. Analysis of The Cancer Genome Atlas database exhibiting high SLC25A17 and SLC27A6 gene expression in prostate cancer patients were associated with poor survival than those with low expression of these proteins. In conclusion, SLC25A17 and SLC27A6 and its interactive network play an essential role in the development of enzalutamide resistance through metabolic reprogramming and may be identified as therapeutic target(s) to circumvent drug resistance.
Inherited Metabolic Memory of High‐Fat Diet Impairs Testicular Fatty Acid Content and Sperm Parameters
Authors: Crisóstomo Luís , Videira Romeu A. , Jarak Ivana , Starčević Kristina , Mašek Tomislav , Rato Luís , Raposo João F. , Batterham Rachel L. , Oliveira Pedro F. , Alves Marco G. 
Published: December 2021

ScopeExposure to a high‐fat diet (HFD) from early‐life is associated with a testicular metabolic signature link to abnormal sperm parameters up to two generations after exposure in mice. Hereby, this study describes a testicular lipid signature associate with “inherited metabolic memory” of exposure to HFD, persisting up to two generations in mice.Methods and ResultsDiet‐challenged mice (n= 36) are randomly fed after weaning with standard chow (CTRL); HFD for 200 days or transient HFD (HFDt) (60 days of HFD + 140 days of standard chow). Subsequent generations (36 mice per generation) are fed with chow diet. Mice are euthanized 200 days post‐weaning. Glucose homeostasis, serum hormones, testicular bioenergetics, and antioxidant enzyme activity are evaluated. Testicular lipid‐related metabolites and fatty acids are characterized by1H‐NMR and GC‐MS. Sons of HFD display impaired choline metabolism, mitochondrial activity, and antioxidant defenses, while grandsons show a shift in testicular ω3/ω6 ratio towards a pro‐inflammatory environment. Grandsons of HFDt raise 3‐hydroxybutyrate levels with possible implications to testicular insulin resistance. Sperm counts decrease in grandsons of HFD‐exposed mice, regardless of the duration of exposure.ConclusionHFD‐induced “inherited metabolic memory” alters testicular fatty acid metabolism with consequences to sperm parameters up to two generations.
Co‐design of Sub‐6 GHz and mm‐wave array antennas with metal frame for 5G mobile terminals
Authors: Ren Taoyu , Deng Changjiang 
Published: December 2021

AbstractIn this letter, a compact antenna module working at Sub‐6 GHz and millimeter‐wave (mm‐wave) bands is presented for 5G mobile terminal applications. The module includes a long slot etched at the edge of the chassis ground and four short slots etched on the metal frame. By placing the two kinds of slots together, the short slots can work at the quarter‐wavelength mode, thus the length of the short slots on the metal frame is merely 1.4 mm. It greatly reduces the risk of signal attenuation by users' touch. Experimental results show that the proposed design can provide MIMO function at 3.5 GHz band, and wide‐angle beam steering function at 28 GHz band.
DEep learning‐based rapid Spiral Image REconstruction (DESIRE) for high‐resolution spiral first‐pass myocardial perfusion imaging
Authors: Wang Junyu , Weller Daniel S. , Kramer Christopher M. , Salerno Michael 
Published: December 2021

The objective of the current study was to develop and evaluate a DEep learning‐based rapid Spiral Image REconstruction (DESIRE) technique for high‐resolution spiral first‐pass myocardial perfusion imaging with whole‐heart coverage, to provide fast and accurate image reconstruction for both single‐slice (SS) and simultaneous multislice (SMS) acquisitions. Three‐dimensional U‐Net–based image enhancement architectures were evaluated for high‐resolution spiral perfusion imaging at 3 T. The SS and SMS MB = 2 networks were trained on SS perfusion images from 156 slices from 20 subjects. Structural similarity index (SSIM), peak signal‐to‐noise ratio (PSNR), and normalized root mean square error (NRMSE) were assessed, and prospective images were blindly graded by two experienced cardiologists (5: excellent; 1: poor). Excellent performance was demonstrated for the proposed technique. For SS, SSIM, PSNR, and NRMSE were 0.977 [0.972, 0.982], 42.113 [40.174, 43.493] dB, and 0.102 [0.080, 0.125], respectively, for the best network. For SMS MB = 2 retrospective data, SSIM, PSNR, and NRMSE were 0.961 [0.950, 0.969], 40.834 [39.619, 42.004] dB, and 0.107 [0.086, 0.133], respectively, for the best network. The image quality scores were 4.5 [4.1, 4.8], 4.5 [4.3, 4.6], 3.5 [3.3, 4], and 3.5 [3.3, 3.8] for SS DESIRE, SS L1‐SPIRiT, MB = 2 DESIRE, and MB = 2 SMS‐slice‐L1‐SPIRiT, respectively, showing no statistically significant difference (p = 1 andp = 1 for SS and SMS, respectively) between L1‐SPIRiT and the proposed DESIRE technique. The network inference time was ~100 ms per dynamic perfusion series with DESIRE, while the reconstruction time of L1‐SPIRiT with GPU acceleration was ~ 30 min. It was concluded that DESIRE enabled fast and high‐quality image reconstruction for both SS and SMS MB = 2 whole‐heart high‐resolution spiral perfusion imaging.
Incompressible flow modeling using an adaptive stabilized finite element method based on residual minimization
Authors: Kyburg Felix E. , Rojas Sergio , Calo Victor M. 
Published: December 2021

AbstractWe model incompressible Stokes flows with an adaptive stabilized finite element method, which solves a discretely stable saddle‐point problem to approximate the velocity‐pressure pair. Additionally, this saddle‐point problem delivers a robust error estimator to guide mesh adaptivity. We analyze the accuracy of different discrete velocity‐pressure pairs of continuous finite element spaces, which do not necessarily satisfy the discrete inf‐sup condition. We validate the framework's performance with numerical examples.
Structural and biochemical analyses of selectivity determinants in chimeric Streptococcus Class A sortase enzymes
Authors: Gao Melody , Johnson D. Alex , Piper Isabel M. , Kodama Hanna M. , Svendsen Justin E. , Tahti Elise , Longshore‐Neate Frederick , Vogel Brandon , Antos John M. , Amacher Jeanine F. 
Published: December 2021

AbstractSequence variation in related proteins is an important characteristic that modulates activity and selectivity. An example of a protein family with a large degree of sequence variation is that of bacterial sortases, which are cysteine transpeptidases on the surface of gram‐positive bacteria. Class A sortases are responsible for attachment of diverse proteins to the cell wall to facilitate environmental adaption and interaction. These enzymes are also used in protein engineering applications for sortase‐mediated ligations (SML) or sortagging of protein targets. We previously investigated SrtA from Streptococcus pneumoniae, identifying a number of putative β7–β8 loop‐mediated interactions that affected in vitro enzyme function. We identified residues that contributed to the ability of S. pneumoniae SrtA to recognize several amino acids at the P1′ position of the substrate motif, underlined in LPXTG, in contrast to the strict P1′ Gly recognition of SrtA from Staphylococcus aureus. However, motivated by the lack of a structural model for the active, monomeric form of S. pneumoniae SrtA, here, we expanded our studies to other Streptococcus SrtA proteins. We solved the first monomeric structure of S. agalactiae SrtA which includes the C‐terminus, and three others of β7–β8 loop chimeras from S. pyogenes and S. agalactiae SrtA. These structures and accompanying biochemical data support our previously identified β7–β8 loop‐mediated interactions and provide additional insight into their role in Class A sortase substrate selectivity. A greater understanding of individual SrtA sequence and structural determinants of target selectivity may also facilitate the design or discovery of improved sortagging tools.
Hepatoprotective effect of acetovanillone against methotrexate hepatotoxicity: Role of Keap‐1/Nrf2/ARE, IL6/STAT‐3, and NF‐κB/AP‐1 signaling pathways
Authors: Abd El‐Ghafar Omnia A. M. , Hassanein Emad H. M. , Ali Fares E. M. , Omar Zainab M. M. , Rashwan Eman K. , Mohammedsaleh Zuhair M. , Sayed Ahmed M. 
Published: December 2021

AbstractThis study targeted to examine the protective effects of acetovanillone (AV) against methotrexate (MTX)‐induced hepatotoxicity. Thirty‐two rats were allocated into four groups of eight animals; Group 1: Normal; Group 2: administered AV (100 ml/kg; P.O.) for 10 days; Group 3: challenged with MTX (20 mg/kg, i.p; single dose); Group 4: administered AV 5 days before and 5 days after MTX. For the first time, this study affords evidence for AV's hepatoprotective effects on MTX‐induced hepatotoxicity. The underlined mechanisms behind its hepatic protection include counteracting MTX‐induced oxidative injury via down‐regulation of NADPH oxidase and up‐regulation of Nrf2/ARE, SIRT1, PPARγ, and cytoglobin signals. Additionally, AV attenuated hepatic inflammation through down‐regulation of IL‐6/STAT‐3 and NF‐κB/AP‐1 signaling. Network pharmacology analysis exhibited a high enrichment score between the interacting proteins and strongly suggested the intricate and essential role of the target proteins regulating MTX‐induced oxidative damage and inflammatory perturbation. Besides, AV increased the in vitro cytotoxic activity of MTX toward PC‐3, HeLa, and K562 cancer cell lines. On the whole, our investigation suggested that AV might be regarded as a promising adjuvant for the amelioration of MTX hepatotoxicity and/or increased its in vitro antitumor efficacy, and it could be used in patients receiving MTX.
Active food packaging to control carbon dioxide
Authors: Lee Dong Sun , Wang Hong Jiang , Jaisan Chalalai , An Duck Soon 
Published: December 2021

AbstractKeeping certain level of carbon dioxide concentration along with a desired oxygen concentration in food packages is helpful in preserving a variety of foods, and thus, active packaging technology to control CO2 has been reviewed here in perspective of optimized package design. For whatever product packages, tailoring interaction among the gas, food product and packaging material is essential for realization of positive role and function of CO2: antimicrobial activity, prevention of oxidation, preferred sensory quality, maintenance of package integrity and extension of shelf life. Gas absorbers, emitters or active valves may be applied for this purpose, and commercial products are available in market. However, these active devices should be applied in harmony with food's CO2 production and dissolution. Elements or factors involved in the design process are examined by looking over scientific literature. Mass balance relationship combined with dissolution equilibration for active food package has been presented to control CO2 concentration and package wholesomeness in beneficial and desired way. Atmosphere estimation of roasted coffee packages was presented as case study for tackling the task of attaining the desired condition.