bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac Tomography and Cardiac Magnetic Resonance to Predict the Absence of Intracardiac Thrombus in Anticoagulated Patients Undergoing Atrial Fibrillation Ablation.
Authors: Zaraket Fatima , Deva Bas , Jimenez Jesus , Casteigt Benjamin , Benito Begoña , Martí-Almor Julio , Conejos Javi , Mojón Diana , Tizón-Marcos Helena , Vallès Ermengol 
Published: August 2021

Abstract
Background: Pulmonary veins isolation (PVI) is a standard treatment for recurrent atrial fibrillation (AF). Uninterrupted anticoagulation for minimum 3 weeks before the ablation and exclusion of left atrial (LA) thrombus with transesophageal echography (TEE) immediately before or during the procedure minimize peri-procedural risk. We aimed to demonstrate the utility of cardiac tomography (CT) and cardiac magnetic resonance (CMR) to rule out LA thrombus prior to PVI. Methods: Patients undergoing PVI for recurrent AF were retrospectively evaluated. Only patients that started anticoagulation at least 3 weeks prior to the CT/CMR and subsequently uninterrupted until the ablation procedure were selected. An intracardiac echo (ICE) catheter was used in all patients to evaluate LA thrombus. The results of CT/CMR were compared to ICE imaging. Results: We included 272 consecutive patients averaging 54.5 years (71% male; 30% persistent AF). Average CHA2DS2VASC Score was 0.9 and mean LA diameter was 43 mm, 111 patients on Acenocumarol and 161 on direct oral anticoagulants. Anticoagulation was started 227±392 days before the CT/CMR, and 291±416 days before the ablation procedure. CT/CMR diagnosed intracardiac thrombus in 2 cases, both in the LA appendage. A new CT/CMR revealed resolution of thrombus after 6 additional months of uninterrupted anticoagulation. No macroscopic thrombus was observed in any patients with ICE (negative predictive value of 100%; p<0.01).Conclusions: CT and MRI are excellent surrogates to TEE and ICE to rule out intracardiac thrombus in patients adequately anticoagulated prior AF ablation. This is true even for delayed procedures as long as anticoagulation is uninterrupted.
Achieving The 1.5 °C Goal with Equitable Mitigation in the Latin American Countries
Authors: Ramírez Cindy , Turon Albert , Retamal Cristián , Alcaraz Olga , Sureda Bàrbara 
Published: August 2021

Abstract
During the past years, the impact of climate change in the Latin America region has become more evident, and is affecting its natural resources and delaying sustainable development. Achieving the 1.5°C long-term temperature goal of the Paris Agreement while ensuring the right to sustainable development, is of particular interest for regions such as Latin America which are highly vulnerable and have a low capacity of adaptation. This article seeks to analyse if the Nationally Determined Contributions (NDCs) submitted within the Paris Agreement framework by the Latin American countries align with achieving the 1.5°C goal. For this analysis, the cumulative emissions for the 2018–2100 period are distributed among the region and its countries using the climate justice criteria (equality and historical responsibility) outlined in the Model of Climate Justice (MCJ). The results of the MCJ compatible with the 1.5°C global temperature scenario are then compared with the cumulative emissions implied in the NDCs submitted by the Latin American countries. Two main conclusions are obtained from the NDC analysis. First, the Latin American region, in 2030, will consume 67.8% of the emissions budget allocated by the MCJ until the end of the century. Second, this percentage could be reduced if, firstly, the conditional commitments within the NDC that require foreign aid are achieved, and, secondly, those countries that will consume their entire emissions budget by 2030 submit reviewed NDCs that increase the ambition of their mitigation commitments.
Dark Triad, Impulsivity And Honesty-Humility And Intended Behavior In A Prisoner’s Dilemma Game: A Simulation Study
Authors: Lainidi Olga , Karakasidou Eirini , Montgomery Anthony 
Published: August 2021

Abstract
Objective: The aim of the study was to investigate if the Dark Triad personality traits, Impulsivity and Honesty-Humility can predict individuals’ intended behavior in one-shot Prisoner’s Dilemma Games (PDG). Method: A cross-sectional correlational design was followed, examining multiple linear regression models. A total sample of 197 Greek adults (64% women, M=35.13 years old) completed a one-shot simulated PDGs, the Dirty Dozen scale, the Barratt Impulsivity Scale and the Honesty-Humility subscale from the HEXACO NEO-PI. Results: Significant correlations between Dirty Dozen scores and Impulsivity, and Dirty Dozen scores and Honesty-Humility (p<.01) where identified. Honesty-Humility predicted Dark Triad scores (p<.01). Dark Triad scores predicted the classification of participants in groups, according to their decision in the first PDG simulation (p<.01), while Honesty/Humility and Impulsivity were not significant predictors.Conclusions: Simulated social situations can serve as situational judgment tests in an effort to develop new measures of personality and a better understanding in the underpinning mechanisms between personality traits and intended behavior in ethical dilemmas and moral judgment.
Factors shaping the abundance and diversity of archaea in the animal gut
Authors: Thomas Courtney , Quemener Elie Desmond-Le , Gribaldo Simonetta , Borrel Guillaume 
Published: August 2021

Abstract
Archaea are active members of the gut microbiome, but a thorough analysis of their diversity and abundance in a wide range of animals is lacking. Here, we examined both quantitatively and qualitatively the gut archaeome of 269 species from invertebrates to primates. Archaea are present across many animals and mostly represented by four genera and one family of methanogens, but also members of Thaumarchaeota. Five major events of adaptation to the gut in the Archaea were identified. Host phylogeny, diet, and intestinal tract physiology are key factors shaping the structure and abundance of the archaeome. The abundance of methanogens is positively correlated with diet fibre content in mammals and hydrogenotrophic methyl-reducing methanogenesis (the main methanogenesis pathway in many animals) is linked to diet and methyl compounds-producing bacteria. Our results provide unprecedented insights on the intestinal archaeome and pave the way for further studies on their role in this environment.
Regional trade agreement burdens global carbon emission mitigation
Authors: Tian Kailan , Zhang Yu , Li Yuze , Ming Xi , Jiang Shangrong , Duan Hongbo , Yang Cuihong , Wang Shouyang 
Published: August 2021

Abstract
Regional trade agreements (RTAs) have been widely adopted to facilitate international trade and cross-border investment and ultimately promote economic development. However, ex ante measurements of the environmental effects of RTAs to date have not been well conducted. Here, we estimate the CO2 emission burdens of the Regional Comprehensive Economic Partnership (RCEP) after evaluating its economic effects. We find that trade among RCEP member countries will increase significantly and economic output will expand with the reduction of regional tariffs. However, the results show that complete tariff elimination among RCEP members would increase the yearly global CO2 emissions from fuel combustion by about 3.12%, which doubles the annual average growth rate of global CO2 emissions in the last decade. The emissions in some developing members will surge. We therefore stress the necessity of balancing carbon mitigation and the pursuit of economic profitability. The technological advancement of emission mitigation and more effective climate policies for international trade are urgently required to avoid undermining international efforts to reduce global emissions.
Clinical Trial Recruiters’ Experiences Working With Trial Eligibility Criteria: Results of an Exploratory, Cross-sectional, Online Survey
Authors: Cragg William , McMahon Kathryn , Oughton Jamie B , Sigsworth Rachel , Taylor Christopher , Napp Vicky 
Published: August 2021

Abstract
BackgroundEligibility criteria are a fundamental element of clinical trial design, defining who can and who should not participate in a trial. Problems with the design or application of criteria are known to occur and pose risks to participants' safety and trial integrity, sometimes also negatively impacting on trial recruitment and generalisability. We conducted a short, exploratory survey to gather evidence on UK recruiters' experiences interpreting and applying eligibility criteria and their views on how criteria are communicated and developed.MethodsOur survey included topics informed by a wider programme of work at the Clinical Trials Research Unit, University of Leeds, on assuring eligibility criteria quality. Respondents were asked to answer based on all their trial experience, not only on experiences with our trials. The survey was disseminated to recruiters collaborating on trials run at our trials unit, and via other mailing lists and social media. The quantitative responses were descriptively analysed, with inductive analysis of free-text responses to identify themes.ResultsA total of 823 eligible respondents participated. 79% of respondents reported finding problems with eligibility criteria in some trials, and 9% in most trials. The main themes in the types of problems experienced were criteria clarity (67% of comments), feasibility (34%) and suitability (14%). 27% of those reporting some level of problem said these problems had led to patients being incorrectly included in trials; 40% said they had led to incorrect exclusions. Most respondents (56%) reported accessing eligibility criteria mainly in the trial protocol. Most respondents (74%) supported the idea that they might review eligibility criteria earlier in the protocol development process.ConclusionsOur survey corroborates other evidence about the existence of suboptimal trial eligibility criteria. Problems with clarity were the most often reported, but the number of comments on feasibility and suitability suggest some recruiters feel eligibility criteria and associated assessments can hinder recruitment to trials. Our proposal for more recruiter involvement in protocol development has strong support and some potential benefits, but questions remain about how best to implement this. We invite other trialists to consider our other suggestions for how to assure quality in trial eligibility criteria.
“There Hasn't Been a Career Structure to Step Into”: A Qualitative Study on Perceptions of Allied Health Clinician Researcher Careers
Authors: Brandenburg Caitlin , Ward Elizabeth C 
Published: August 2021

Abstract
Background: There are many demonstrated benefits for health service organisations engaging in research. As a result, growing numbers of clinicians are being encouraged to pursue research as part of their clinical roles, including in Allied Health (AH). However, while the benefits of having clinician researchers embedded in AH services have been well-established, the career needs of those engaged in these dual roles is poorly understood. The aim of this study was to examine perspectives of the career pathway for Allied Health clinicians engaged in “clinician researcher” roles within Australian health services. Methods: A qualitative descriptive study was conducted, utilising semi-structured interviews. Purposive sampling was used to ensure selection of varied locations, professions and role types. Results were analysed using thematic analysis. Trustworthiness was established using regular peer debriefing during theme development, and respondent validation of final themes.Results: Fifty-seven AH clinician researchers, including those who did and did not have research as a formal component of their current role, participated in semi-structured interviews. Key themes were that: (1) Clinician researchers prefer roles which are embedded in health services; (2) Current opportunities for clinician researcher roles in health are insufficient; (3) There are deficiencies in the pathway for clinician researcher careers; (4) Clinician researchers are not always valued or incentivised by health services; (5) The current career challenges impair the viability of clinician researcher careers; and (6) The clinician researcher career path has been improving and there is hope it will continue to improve.Conclusion: This study outlines a number of weaknesses with the current career structure and opportunities for AH clinician researchers in Australian health services. In particular, while there are strong intrinsic drivers to pursue this dual career, extrinsic drivers are poorly developed, including a lack of job opportunities, an unstable career pathway and a lack of value or incentivization of this career choice. This often means that clinician researchers feel compelled to choose between a research or clinical career, leading to loss of this valuable combined skillset. The findings of this research may assist health services to develop and support improved clinician researcher career pathways.
Epidemiological and Clinical Characteristics of Headache Among Medical Students in Palestine : A cross Sectional Study
Authors: Anaya Firas M. , Alia Wala’a Abu , Hamoudeh Feda’a , Nazzal Zaher A. , Maraqa Beesan 
Published: August 2021

Abstract
Background Headache is one of the most disturbing complaints worldwide, negatively impacting social and regular life activities.In the background of stressful life in medical schools, adding to the stressful situation in Palestine, a developing country under occupation, this study investigated the prevalence and clinical characteristics of migraines and tension headaches among medical students from the Palestinian Universities in West Bank and GazaMethods:A questionnaire-based cross-sectional study was conducted on all Palestinian Medical Students. Students were diagnosed based on ICHD-3 criteria. Demographic characteristics were compared by gender for each type of headache. Frequency, percentage, and mean ± SD. Pearson's chi-squared test, independent t-test, and one-way ANOVA were used where needed. P-value < 0.05 was considered significant.Results:The study included 806 medical students; 476 (59.0%) of them were female. TTH and migraine's prevalence was 59.8% and 22%, respectively, with a higher prevalence among basic year students. The female to male ratio was 1:0.6 for both types of headaches. Sleep deprivation, physical activities, and altered sleep patterns were reported as the top triggering factors.ConclusionsThe results demonstrate that the prevalence of both subtypes' primary headache is high among Palestinian medical students, with a higher prevalence among basic year students. The study also showed that these findings are higher than other studies among medical students in other countries.
Scalable Reaction Network Modeling with Automatic Validation of Consistency in Event-B
Authors: Sanwal Usman , Hoang Thai Son , Petre Luigia , Petre Ion 
Published: August 2021

Abstract
Constructing a large biological model is a difficult, error-prone process. Small errors in writing a part of the model cascade to the system level and their sources are difficult to trace back. In this paper we extend a recent approach based on Event-B, a state-based formal method with refinement as its central ingredient, allowing us to validate for model consistency step-by-step in an automated way. We demonstrate this approach on a model of the heat shock response and its scalability on a model of the ErbB signaling pathway, a key evolutionary pathway with a significant role in development and in many types of cancer. All consistency properties of the model were proved automatically with computer support.
De Novo Nonsense Variant in ASXL3 in a Chinese Girl Causing Bainbridge–Ropers Syndrome: A Case Report and Review of Literature
Authors: Wang Qin , Zhang Jianming , Jiang Nan , Xie Jiansheng , Yang Jingxin , Zhao Xiaoshan 
Published: August 2021

Abstract
Background: Bainbridge-Ropers syndrome (BRPS, OMIM #615485) was first identified in 2013 by Bainbridge et al. and is a neurodevelopment disorder characterized by failure to thrive, facial dysmorphism, and severe developmental delay. BRPS is caused by heterozygous loss-of function (LOF) variants in the additional sex combs-like 3 (ASXL3) gene which are mostly located in two mutational cluster regions (MCR). Due to the limited specific recognizable features and overlapping symptoms with Bohring–Opitz syndrome, clinical diagnosis of BRPS is challenging. Case presentation: In this study, a 2-year-8-month-old Chinese girl was referred for genetic evaluation of severe developmental delay. Reduced fetal movement was found during antenatal period and bilateral varus deformity of feet was observed at birth. Whole exome sequencing and Sanger sequencing were used to detect and confirm the variant. A novel nonsense variant c.1063G>T (p.E355X) in the ASXL3 gene (NM_030632.3) was identified in the proband and the clinical symptoms were compatible with BRPS. The parents were physical and genetic normal and prenatal diagnosis was requested for her pregnant mother with a negative Sanger sequencing result. Conclusion: The study revealed a de novo LOF variant in the ASXL3 gene and expanded the mutation spectrum for this clinical condition. By performing a literature review, we analyzed the clinical phenotype with limited fetal features and summarized genetic results of all BPRSs reported so far. More cases study may help to elucidate the function of ASXL3 gene that may be critical to understand the genetic etiology of this syndrome and assist in accurate genetic counselling, informed decision making and prenatal diagnosis.
Breakdown of semiclassical description of thermoelectricity in near-magic angle twisted bilayer graphene
Authors: Ghawri Bhaskar , Mahapatra Phanibhusan , Garg Manjari , Mandal Shinjan , Bhowmik Saisab , Jayraman Aditya , Soni Radhika , Watanabe Kenji , Taniguchi Takashi , Krishnamurthy Hulikal , Jain Manish , Banerjee Sumilan , Chandni U. , Ghosh Arindam 
Published: August 2021

Abstract
The planar assembly of twisted bilayer graphene (tBLG) hosts a multitude of interaction-driven phases when the relative rotation is close to the magic angle (θ = 1.1°). This includes correlation-induced ground states that reveal spontaneous symmetry breaking at low temperature, as well as
the possibility of non-Fermi liquid (NFL) excitations. However, experimentally, the manifestation of NFL
effects in transport properties of twisted bilayer graphene remains ambiguous. Here we report simultaneous measurements of electrical resistivity (ρ) and thermoelectric power (S) in tBLG for several twist angles between θ ≈ 1.0°-1.7°. We observe an emergent violation of the semiclassical Mott relation in the form of excess S close to half-filling for θ≈1.6° that vanishes for ≥ 2°. The excess S (≈2 μV/K at low temperatures T ≈10 K at θ≈1.6°) persists up to ≈ 40 K
and is accompanied by metallic T-linear ρ with transport scattering rate (1/τ) of near-Planckian magnitude 1/τ ≈ k_BT/h_bar. Closer to θ_m, the excess S was also observed for fractional band-filling (ν≈ 0.5). The combination of non-trivial electrical transport and violation of Mott relation provides compelling evidence of NFL physics intrinsic to tBLG.
Access to Monomeric Hydridoplumbate(II) Anions with Remarkable Thermostability
Authors: Wang Shuo , Li Han-Jung , Lee Wan-Ching , Huang Shuo-Ling , Wu Wen-Chun , Shi Fong-Ku , Kuo Ting-Shen , Lu I-Chung , Liu Hsueh-Ju 
Published: August 2021

Abstract
We report on the remarkable stability of synthesized monomeric hydridoplumbates M+[LPb(II)H]− (M[1-H]) where L = 2,6-bis(3,5-diphenylpyrrolyl)pyridine and M = (18-crown-6)potassium or ([2.2.2]-cryptand)potassium. The half-life of [K18c6][1-H] is approximately 2 days in tetrahydrofuran at ambient temperature. The presence of a Pb–H bond in the hydridoplumbates was unambiguously identified by performing 1H, 2H (with a lead(II) deuteride analogue), 207Pb{1H}, proton-coupled 207Pb, and 1H-207Pb 2D nuclear magnetic resonance spectroscopy. The experimental observations and theoretical calculations indicated the presence of dihydrogen bonding as a secondary coordination sphere interaction between the protons of the ligand backbone and the hydride ligand that helps stabilize Pb–H bonding. The Pb–H bond readily adds to the C = O bond of benzaldehyde to form a benzyloxy compound. The regeneration of Pb(II)–H moieties was observed by treating pinacolborane with lead(II) benzyloxy compounds, which indicated that lead(II) hydrides can be used as catalysts for hydroelementation reactions involving unsaturated molecules.
How Harvest More Ambient Energy from Environmental Vibration with a Multiple-Frequency Excitation
Authors: Song Jiawen , Sun Guihong , Zeng Xin , Li Xiangwen , Bai Quan , Zheng Xuejun 
Published: August 2021

Abstract
We propose piezoelectric energy harvester (PEH) with double-cantilever-beam (DCB) undergoing coupled bending-torsion vibrations by combining width-splitting method and asymmetric mass, in order that more ambient energy could be harvested from environmental vibration with multiple-frequency excitation. The geometrical dimensions are optimized for PEHDCB, when the maximum of output peak voltages Up−max and resonance frequency difference (Δf0) between the first and second modes are chosen as optimization objectives based on orthogonal test method. The energy harvesting efficiency is evaluated by the proportion of half-power bandwidth and quality factor, and the experimental and simulation results are compared to verify reliability. The Up−max1 and Pp−max1 are increased 25.2% and 57.3% for PEHDCB under the multi-frequency excitation, when the split-width method is applied into PEH with single-cantilever-beam (SCB) undergoing coupled bending-torsion vibrations. The deviations of Up−max1 and f0 are at the ranges of 4.9–14.2% and 2.2–2.5% for PEHDCB under the different mass ratios, and the measurement reliability is acceptable considering incomplete clamping, damping and inevitable assembly effects. The energy harvesting efficiency of PEHDCB presented is much higher than that of the conventional PEHSCB from environmental vibration with multiple-frequency excitation.
ChIP-Hub: an Integrative Platform for Exploring Plant Regulome
Authors: Fu Liang-Yu , Zhou Xinkai , Yu Ranran , Wu Zhigui , Zhang Peijing , Chen Ming , Kaufmann Kerstin , Chen Dijun 
Published: August 2021

Abstract
Plant genomes encode a complex and evolutionary diverse regulatory grammar that forms the basis for most life on earth. A wealth of regulome and epigenome data have been generated in various plant species, but no common, standardized resource is available so far for biologists. Here we present ChIP-Hub, an integrative web-based platform in the ENCODE standards that bundles > 10000 publicly available datasets reanalyzed from > 40 plant species, allowing visualization and meta-analysis. We manually curate the datasets through assessing ~ 540 original publications and comprehensively evaluate their data quality. As a proof of concept, we extensively survey the co-association of different regulators and construct a hierarchical regulatory network under a broad developmental context. Furthermore, we show how our annotation allows to investigate the dynamic activity of tissue-specific regulatory elements (promoters and enhancers) and their underlying sequence grammar. Finally, we analyze the function and conservation of tissue-specific chromatin states based on comparative genomics. Taken together, the ChIP-Hub platform and the analysis results provide rich resources for deep exploration of plant ENCODE.