bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE NOVICE ENGLISH TEACHERS' PERSPECTIVES TOWARDS ONE-PAGE LESSON PLAN PRINCIPLES AT SMP LABORATORIUM UNDIKSHA SINGARAJA
Authors: Novitasari Ni Luh Ayu , Purnamika I.G.A Lokita , Suputra Putu Eka Dambayana 
Published: August 2021

Abstract: The purpose of this study is to analyze the novice English teachers' perspectives on the one-page lesson plan principles at SMP Laboratorium Undiksha Singaraja. A case study qualitative design was used in this study. This study's data collection method included in-depth interviews to understand the novice teachers' perspectives. The subjects were two novice English teachers at SMP Laboratorium Undiksha Singaraja. The result showed the novice English teachers agreed one-page lesson plan is more efficient, effective, and students' oriented. However, novice English teachers had different perspectives for gathering students' information about the students' readiness, interests, and needs. This study implies that this one-page lesson plan policy needs to be sustained due to the English teachers' positive response.
Keywords: Novice teachers; One-page lesson plan; Perspectives.

Abstract: Penelitian ini bertujuan untuk menganalisis perspektif dari guru bahasa Inggris baru mengenai prinsip – prinsip RPP satu halaman di SMP Laboratorium Undiksha Singaraja. Penelitian ini menggunakan metode penelitian studi kasus kualitatif. Metode pengumpulan data yang digunakan pada penelitian ini menggunakan interview mendalam untuk memahami perspektif para guru baru bahasa Inggris lebih mendalam. Subjek penelitian ini menggunakan dua guru bahasa Inggris baru di SMP Laboratorium Undiksha Singaraja. Hasil dari penelitian ini menunjukkan bahwa para guru bahasa Inggris baru setuju bahwa RPP satu halaman lebih efisien, efektif dan berorientasi pada siswa. Walaupun demikian, para guru bahasa Inggris baru tersebut memiliki perbedaan perspektif didalam mengumpulkan informasi mengenai kesiapan, ketertarikan, dan kebutuhan belajar siswa mereka. Implikasi dari penelitian ini menunjukkan bahwa peraturan RPP satu halaman harus tetap digunakan secara berkelanjutan karena respon positif dari para guru bahasa Inggris baru tersebut.
Kata kunci: Guru baru; Perspektif; RPP satu halaman.
Effect of Caulerpa Cylindracea Extract on Histopathology Depiction of Male Rattus Norvegicus Gaster Mucosa Induced by Indomethacin
Authors: HANDAJANI FITRI , Hidayatullah Adya , Pranitasari Nita 
Published: August 2021

ABSTRACT
Background: A lot of food can repair gastric mucosal damage. For example, sea grapes or the Caulerpa cylindracea with its flavonoid content. Anti-inflammatory and anti-ulcer effect can reduce gastric lesions due to ulcerogenic agents. Indomethacin is used to induce gastric ulcers in experimental animals. Based on this background, this study was conducted to analyze the effect of Caulerpa cylindracea extract, on the histopathological picture of gastric mucosal damage of Rattus norvegicus male rats.

Method: 32 male Rattus norvegicus rats were divided into 4 groups, (1) Group K(-), the untreated group, (2) Group K(+) induced by indomethacin 30mg/kgBB per head (3) Group P1 induced by indomethacin 30 mg/kgBB and Caulerpa cylindracea extract 1gr/100grBB per head, (4) Group P2, induced by indometacin 30mg/kgBB and 2gr/100grBB of Caulerpa cylindracea extract per head.

Result: There was a significant difference (p = 0.001) between the degree of gastric mucosal damage in group K(+) given only indomethacin and group P1 given Indomethacin and 1gr/100grBB Caulerpa cylindracea extract. There was a significant difference (p = 0.001) between group K(+) and group P2 that given Indomethacin and 2g/100grBB Caulerpa cylindracea extract. There was a significant difference (p = 0.004) between group P1 and group P2. Data revealed on group K(-) without any treatment did not obtain significant results (p = 0.060) with group P2.

Conclusion: Giving Caulerpa cylindracea extract with 1 gr/100grBB dose and 2gr/100grBB dose can repair mucosal damage in Rattus norvegicus male rats induced by indomethacin.
Neutrino masses and interactions and neutrino experiments in the laboratory
Authors: Šimkovic F 
Published: August 2021

Abstract
The atomic nucleus offers a unique opportunity to study fundamental properties and interactions of neutrinos. The main subjects of interest are the nature of neutrinos (Dirac or Majorana), mass hierarchy, the absolute scale of neutrino masses, and possible additional sterile neutrinos. In this review, recent progress in the field of laboratory measurements of fundamental properties of neutrinos is briefly presented.
Peningkatan Pengetahuan Anak Sekolah Dasar tentang Dampak Jajan Sembarangan Bagi Kesehatan
Authors: Devriany Ade 
Published: August 2021

Kebiasaan jajan sembarangan pada anak-anak memiliki risiko serta dampak yang buruk bagi kesehatan. Bagi anak yang tidak terbiasa makan pagi, makanan jajanan berfungsi sebagai makanan yang pertama kali masuk ke saluran pencernaan, sehingga jajanan menjadi penting artinya. Namun, diketahui banyak kandungan zat kimia pada jajanan yang bertentangan dengan tubuh seperti boraks, formalin, MSG. Kegiatan ini bertujuan meningkatkan pengetahuan siswa SD tentang kandungan zat kimia dalam jajanan tersebut serta bahaya yang ditimbulkannya bagi kesehatan. Metode yang digunakan adalah penyuluhan dengan metode ceramah dan diskusi. Penyampaian materi melalui video animasi dan permainan tentang akibat jajan sembarangan dan cara memilih jajanan sehat. Berdasarkan hasil penilaian pre-test, terdapat 51,95% siwa-siswa dengan tingkat pengetahuan yang cukup dan 48,05% dengan kategori pengetahuan yang baik. Setelah mendapatkan penyuluhan, post-test meningkat yaitu 7,79% peserta dengan kategori pengetahuan cukup paham, 50,64% pengetahuan yang baik dan 41,57% sangat baik. Kesimpulannya bahwa penyuluhan tentang bahaya dan dampak jajan sembarangan dapat dimengerti oleh peserta. Dengan demikian, diharapkan peran serta aktif pihak sekolah terutama bagi siswa dalam pencegahan jajan sembarangan dapat menjadi lebih baik agar kejadian penyakit akibat jajan sembarangan dapat dikurangi.
Boosting the Productivity of H2-Driven Biocatalysis in a Commercial Hydrogenation Flow Reactor Using H2 From Water Electrolysis
Authors: Poznansky Barnabas , Cleary Sarah E. , Thompson Lisa A. , Reeve Holly A. , Vincent Kylie A. 
Published: August 2021

Translation of redox biocatalysis into a commercial hydrogenation flow reactor, with in-built electrolytic H2 generation, was achieved using immobilized enzyme systems. Carbon-supported biocatalysts were first tested in batch mode, and were then transferred into continuous flow columns for H2-driven, NADH-dependent asymmetric ketone reductions. The biocatalysts were thus handled comparably to heterogeneous metal catalysts, but operated at room temperature and 1–50 bar H2, highlighting that biocatalytic strategies enable implementation of hydrogenation reactions under mild–moderate conditions. Continuous flow reactions were demonstrated as a strategy for process intensification; high conversions were achieved in short residence times, with a high biocatalyst turnover frequency and productivity. These results show the prospect of using enzymes in reactor infrastructure designed for conventional heterogeneous hydrogenations.
Late Mesozoic Intracontinental Deformation in the Northern Margin of the North China Craton: A Case Study From the Shangyi Basin, Northwestern Hebei Province, China
Authors: Yang Qian , Shi Wei , Hou Guiting , Zhang Yu , Zhao Yilin 
Published: August 2021

During the late Mesozoic, the East Asian continent underwent a complex tectonic history due to multiple episodes of plate convergence. How the crust responds to the multiple plate convergence in the North China Craton (NCC) remains unclear. Here we undertook field geological investigations and fault-slip vectors analysis of the Shangyi Basin in the western Yanshan fold and thrust belt, northern margin of the NCC. Combined with new geochronological data, we delineate three phases of intracontinental deformation in the area: 1) NW-SE compression during the Late Jurassic to earliest Cretaceous (ca. 151–141 Ma); 2) NW-SE extension during the middle–late Early Cretaceous (ca. 135–110 Ma); and 3) NE-SW compressional deformation later than 110 Ma. The early NW-SE compression controlled the present bulk architecture of the basin, and the subsequent two tectonic events only caused limited reworking of the previous structures. Through balanced cross-section restoration, we estimate the horizontal shortening ratio of the crust in the study area is over 27% due to the NW-SE compression. Moreover, the contribution of tectonic shortening from the north side of the basin is greater than that from the south side. NW-SE compressional deformation is consistent in time with the episode B of the Yanshanian movement (Yanshanian B), which may be influenced by the subduction of the Paleo-Pacific plate beneath East Asia and the closure of the Mongol-Okhosk Ocean. Subsequent NW–SE extension is likely to be associated with the destruction of the NCC during the Early Cretaceous. Extension may result from the roll-back of the Paleo-Pacific plate and post-orogenic collapse of the Mongol-Okhotsk belt. The last NE-SW compressional event may be linked to the remote effect of the final collision between the Qiangtang and Lhasa terranes.
Vitamin D Level and Vitamin D Receptor Genetic Variation Were Involved in the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study
Authors: Zhang Ru , Wang Minxian , Wang Min , Zhang Liuxin , Ding Yajie , Tang Zongzhe , Fu Zuqiang , Fan Haozhi , Zhang Wei , Wang Jie 
Published: August 2021

BackgroundIt has been demonstrated that vitamin D receptor (VDR), a key gene in the metabolism of vitamin D (VD), may affect the development of Non-alcoholic fatty liver disease (NAFLD) by regulating VD level and its biological effects.ObjectivesTo investigate the effects of serum VD level, VDR variation, and a combination of VDR SNP and environmental behavior factor on the risk of NAFLD.MethodsA total of 3023 subjects from a community in Nanjing were enrolled, including 1120 NAFLD cases and 1903 controls. Serum 25(OH)D3 levels were measured and eight single nucleotide polymorphisms (SNPs) in VDR gene were genotyped.ResultsLogistic regression analyses indicated that VD sufficiency and VD insufficiency were significantly associated with a low risk of NAFLD (all P&lt;0.05; all Ptrend&lt;0.05, in a locus-dosage manner). After adjusting for gender and age, VDR rs2228570-A and rs11168287-A alleles were all reduced the risk of NAFLD (all PFDR=0.136, in dominant model; Ptrend =0.039, combined effects in a locus-dosage manner). The protective effects of two favorable alleles were more evident among subjects ≤40 years, non-hypertension, non-hyperglycemia and non-low high density lipoprotein-cholesterol (all P&lt;0.05). The area under the receiver operating curve of the combination of VDR SNP and exercise time for assessing NAFLD risk was slightly higher than that of only including exercise time or neither (all P&lt;0.05).ConclusionHigh serum VD levels and VDR variants (rs2228570-A and rs11168287-A) might contribute to a low risk of NAFLD in Chinese Han population. The inclusion of VDR SNP and exercise time could improve the efficiency in assessment of NAFLD risk, which might provide a novel perspective for early screening and preventing NAFLD.
Biogas Technology as an “Engine” for Facilitating Circular Bio-Economy in Denmark—The Case of Lolland & Falster Municipalities Within Region Zealand
Authors: Lybæk Rikke , Kjær Tyge 
Published: August 2021

This article investigates how biogas technology can facilitate the deployment of municipal circular bio-economic solutions within the energy and agrarian sectors in Denmark. The emphasis is on the regional climate policy and the existing biogas technology concepts, within a decentralized energy market located in the Southern part of Zealand. The case analysis will identify how such technology can be utilized as a lever for future “extraction-activities,” as for example protein, wax, and furfural substrates. Within Falster &amp; Lolland Municipalities, it is identified that 800.000 tons of animal manure is readily available for biogas production, just as 880.000 tons and 220.000 tons of unused beet tops and residual cereal straw could be feed to biogas facilities as for example co-silage materials. With a potential gas yield of approximately 897.000 MWh, composed by the crop residues alone, the challenge is how to utilize such resources the most efficient when addressing future needs for bio-products and high value materials and energy. Through the lens of Circular Bio-Economy this article addresses three themes, by which biogas technology can become an “engine” for future bioenergy solutions, where cascading activities and use of side-streams are developed: 1) production of biogas by means of local agricultural residues (beet tops, residual straw, and animal manure), combined with 2) “extraction-activities” as furfural and wax from straw, as well as protein from beet tops. Besides this 3) opportunities for upgrading the biogas and distributing it on a natural gas network, hereby enlarging the supply market for energy services from the biogas plant and facilitating the development of a more “integrated energy system,” currently being promoted by the European Commission. This article concludes on a step-by-step approach to utilize biomass residues more efficiently in light of the CBE concept and cascading approach, and the available biomass resources within the specific case area addressed.
Identification of Distinct Molecular Patterns and a Four-Gene Signature in Colon Cancer Based on Invasion-Related Genes
Authors: Dong Yunfei , Shang Tao , Ji HaiXin , Zhou Xiukou , Chen Zhi 
Published: August 2021

BackgroundThe pathological stage of colon cancer cannot accurately predict recurrence, and to date, no gene expression characteristics have been demonstrated to be reliable for prognostic stratification in clinical practice, perhaps because colon cancer is a heterogeneous disease. The purpose was to establish a comprehensive molecular classification and prognostic marker for colon cancer based on invasion-related expression profiling.MethodsFrom the Gene Expression Omnibus (GEO) database, we collected two microarray datasets of colon cancer samples, and another dataset was obtained from The Cancer Genome Atlas (TCGA). Differentially expressed genes (DEGs) further underwent univariate analysis, least absolute shrinkage, selection operator (LASSO) regression analysis, and multivariate Cox survival analysis to screen prognosis-associated feature genes, which were further verified with test datasets.ResultsTwo molecular subtypes (C1 and C2) were identified based on invasion-related genes in the colon cancer samples in TCGA training dataset, and C2 had a good prognosis. Moreover, C1 was more sensitive to immunotherapy. A total of 1,514 invasion-related genes, specifically 124 downregulated genes and 1,390 upregulated genes in C1 and C2, were identified as DEGs. A four-gene prognostic signature was identified and validated, and colon cancer patients were stratified into a high-risk group and a low-risk group. Multivariate regression analyses and a nomogram indicated that the four-gene signature developed in this study was an independent predictive factor and had a relatively good predictive capability when adjusting for other clinical factors.ConclusionThis research provided novel insights into the mechanisms underlying invasion and offered a novel biomarker of a poor prognosis in colon cancer patients.
Functional Gastrointestinal Disorders in Patients With Epilepsy: Reciprocal Influence and Impact on Seizure Occurrence
Authors: Avorio Federica , Cerulli Irelli Emanuele , Morano Alessandra , Fanella Martina , Orlando Biagio , Albini Mariarita , Basili Luca M. , Ruffolo Gabriele , Fattouch Jinane , Manfredi Mario , Russo Emilio , Striano Pasquale , Carabotti Marilia , Giallonardo Anna T. , Severi Carola , Di Bonaventura Carlo 
Published: August 2021

Introduction: The complex relationship between the microbiota-gut-brain axis (MGBA) and epilepsy has been increasingly investigated in preclinical studies. Conversely, evidence from clinical studies is still scarce. In recent years, the pivotal role of MGBA dysregulation in the pathophysiology of functional gastrointestinal disorders (FGID) has been recognized. With this background, we aimed to investigate the prevalence of FGID in patients with epilepsy (PWE) and the possible impact of bowel movement abnormalities on seizure recurrence.Methods: A total of 120 PWE and 113 age-, sex-, and BMI-matched healthy subjects (HS) were consecutively enrolled. A questionnaire to evaluate the presence of FGID (according to Rome III diagnostic criteria) was administrated to all participants. In a subgroup of drug-resistant patients, we administered an ad-hoc questionnaire combining Bristol stool charts and seizure diaries to evaluate seizure trends and bowel movement changes.Results: A higher prevalence of FGID in PWE (62.5%) than in HS (39.8%) was found (p &lt; 0.001). The most frequently observed disorder was constipation, which was significantly higher in PWE than in HS (43.3 vs. 21.2%, p &lt; 0.001), and was not associated with anti-seizure medication intake according to multivariable analysis. In drug-resistant patients, most seizures occurred during periods of altered bowel movements, especially constipation. A significant weak negative correlation between the number of days with seizures and the number of days with normal bowel movements was observed (p = 0.04). According to multivariable logistic regression analysis, FGID was significantly associated with temporal lobe epilepsy as compared with other lobar localization (p = 0.03).Conclusions: Our clinical findings shed new light on the complex relationship between epilepsy and the MGBA, suggesting a bidirectional link between bowel movement abnormalities and seizure occurrence. However, larger studies are required to better address this important topic.
Safety and Effectiveness of High-Precision Hyperthermic Intraperitoneal Perfusion Chemotherapy in Peritoneal Carcinomatosis: A Real-World Study
Authors: Ba Mingchen , Cui Shuzhong , Long Hui , Gong Yuanfeng , Wu Yinbing , Lin Kunpeng , Tu Yinuo , Zhang Bohuo , Wu Wanbo 
Published: August 2021

BackgroundHyperthermic intraperitoneal chemotherapy (HIPEC) has been reported to effectively control peritoneal carcinomatosis (PC) in various patient populations, but there is a lack of real-world data. This study aimed to examine the safety and effectiveness of HIPEC in patients with PC in a real-world setting.MethodsThis was a retrospective study of patients with PC treated with the high-precision BR-TRG-I type HIPEC device between December 2006 and December 2016. Vital signs during HIPEC and adverse events were recorded. Effectiveness was evaluated by total objective remission rate (ORR), which was based on ascites’ remission 4 weeks after HIPEC.ResultsA total of 1,200 patients were included. There were 518 males and 682 females, with a mean age of 58.6 ± 6.5 years (range, 32–76 years). Among the patients, 93.6% of the patients (1123/1200) successfully received the three sessions of HIPEC, 158 had massive ascites. The changes of vital signs during HIPEC were within acceptable ranges, and patients only had a transient fever and abdominal distension. Regarding the HIPEC-related complications, hemorrhage was observed in seven (0.6%) patients, anastomotic leakage in four (0.5%), and intestinal obstruction in eight (0.7%). Nine (0.8%, 9/1200) patients had CTCAE grade IV bone marrow suppression, and three (0.3%, 3/1200) patients had severe renal failure (SRF), which were considered to be drug-related. The ORR of malignant ascites was 95.6% (151/158).ConclusionThis real-world study strongly suggests that HIPEC was safe in treating PC patients with a low rate of adverse events and leads to benefits in PC patients with massive malignant ascites.
Case Report: Dual Checkpoint Inhibition in Advanced Metastatic Osteosarcoma Results in Remission of All Tumor Manifestations—A Report of a Stunning Success in a 37-Year-Old Patient
Authors: Sterz Ulrich , Grube Matthias , Herr Wolfgang , Menhart Karin , Wendl Christina , Vogelhuber Martin 
Published: August 2021

BackgroundPatients with unresectable metastasized osteosarcoma have a poor prognosis. Current treatment options do not offer a chance to cure the disease in this situation. Despite the fact that immunotherapy has expanded its indications continuously over previous years, its use is not yet established in osteosarcoma. There is a lack of randomized controlled studies that could show a significant benefit in this rare tumor entity. So far, efficacy of immunotherapy is only reported in individual cases as well as in mouse models. To predict a response to immunotherapy, testing for programmed death-ligand 1 (PD-L1) expression, microsatellite instability (MSI), and tumor mutational burden (TMB) can be useful, but status is not yet clear for most cancer entities.MethodsSingle case study and review of the literature.Case PresentationThis report presents the case of a 37-year-old patient with metastatic advanced osteosarcoma, who had no more established options for tumor treatment left. PD-L1 expression in the most recent tumor sample was high (tumor proportion score (TPS) 90%, combined positive score (CPS) 92%) but no MSI could be detected. In an individual therapy attempt, an ongoing and profound remission of all tumor manifestations due to four cycles of immunotherapy with ipilimumab and nivolumab was reached. Despite discontinuation of immunotherapy for 3 months due to therapy-related pneumonitis, remission of all tumor manifestations was ongoing, and no detectable relapse in restaging before onset of Nivolumab-maintenance could be observed.ConclusionThe present case constitutes the first report of an adult patient with metastasized advanced osteosarcoma who reached a deep remission of disease by immunotherapy with ipilimumab and nivolumab, which continued even though immunotherapy had to be interrupted. To verify whether the high expression of PD-L1, as seen in this patient, is a predictive marker for response to immunotherapy in osteosarcoma, requires further investigation.