bluuebunny/crossref_metadata_2025_split huggingface dataset:
Picturing an industrial city: green and modern? Postcards from Chemnitz and Lodz (1880s–1980s)
Authors: Kisiel Piotr 
Published: February 2021

AbstractA pictorial postcard condenses a cityscape into one iconic image, which claims to summarize the place, usually in a highly aestheticized version. If that is the case, how does one present an industrial city: with factories and worker housing or rather with churches and the palaces of industrial tycoons? Using four digitalized collections (over 700 postcards) this article analyses images of industrialized cities from the late nineteenth century until the end of the Cold War. The main argument is that this idealized depiction does not focus on industry, but rather taps into the imagination of the European city.
Embracing Uncertainty: Modeling Uncertainty in EPMA—Part II
Authors: Ritchie Nicholas W.M. 
Published: February 2021

AbstractThis, the second in a series of articles present a new framework for considering the computation of uncertainty in electron excited X-ray microanalysis measurements, will discuss matrix correction. The framework presented in the first article will be applied to the matrix correction model called “Pouchou and Pichoir's Simplified Model” or simply “XPP.” This uncertainty calculation will consider the influence of beam energy, take-off angle, mass absorption coefficient, surface roughness, and other parameters. Since uncertainty calculations and measurement optimization are so intimately related, it also provides a starting point for optimizing accuracy through choice of measurement design.
A compact L-band bandpass filter based on SIR coaxial resonators with high multipactor threshold
Authors: Benedicto J. , Rius E. , Favennec J.-F. , Pacaud D. , Carpentier L. , Puech J. 
Published: February 2021

AbstractThis paper presents the design of a sixth-order cross-coupled L-band filter, specifically intended for space applications. The solution was based on the principle of stepped impedance coaxial resonators (SIRs), which allowed us to fulfill several electrical and size specifications and more particularly a high multipactor threshold. The degrees of freedom afforded by the proposed topology offer a wide choice of design configuration possibilities. Whatever the central frequency and required specifications, several compromises can be made in terms of volume, height, footprint, quality factor, multipactor threshold, harmonic rejection, etc. For instance, SIR coaxial topology is very well suited to small L-band filters when moderate quality factors and multipactor thresholds of around 4000 and 400 W, respectively, are requested. The design procedure is presented and simulations and measurements are compared and discussed.
Microwave synthesis of Bessel, Bessel–Gauss, and Gaussian beams: a fully vectorial electromagnetic approach
Authors: Fuscaldo Walter , Benedetti Alessio , Comite Davide , Burghignoli Paolo , Baccarelli Paolo , Galli Alessandro 
Published: February 2021

AbstractBessel, Bessel-Gauss, and Gaussian beams have widely been investigated in optics in the paraxial approximation, under the frame of a scalar wave theory. Such approximations can hardly be applied in the microwave/millimeter-wave range, where the vectorial nature of the electromagnetic fields cannot be neglected, and experimental realizations for some of these beams appeared only recently. In this work, we discuss the generation of Bessel, Bessel-Gauss, and Gaussian beams through a fully vectorial electromagnetic approach. The field derivation of all these beams is first illustrated and numerical evaluations are then reported to compare their different propagation and diffractive behaviors. Finally, an innovative approach for realizing such solutions with planar microwave devices exploiting leaky waves is demonstrated through accurate numerical simulations.
The Mediterranean Region as a Paradigm of the Global Decoupling of N and P Between Soils and Freshwaters
Authors: Romero Estela , Ludwig Wolfgang , Sadaoui Mahrez , Lassaletta Luis , Bouwman Alexander F. , Beusen Arthur H. W. , van Apeldoorn Dirk , Sardans Jordi , Janssens Ivan A. , Ciais Philippe , Obersteiner Michael , Peñuelas Josep 
Published: February 2021

AbstractThe global socio‐economic and agricultural expansion is accompanied by large inputs of nitrogen (N) and phosphorus (P) on land and by a serious alteration of the water cycle and water quality. The Mediterranean basin represents a paradigmatic region to study the entangled nutrient and water challenges because the region, where many of the world's climatic and socio‐economic gradients are present, is predicted to suffer severe water stress in the coming decades yet at the same time agricultural intensification and population are increasing in many rim countries. We here describe the biogeochemical budgets of N and P in 549 river basins for the 2000–2009 period, analyzing how the climatic gradient and water management practices affect the fluxes of N and P and their stoichiometric ratios. Average land inputs are 3,600 kg N km−2 yr−1 and 470 kg P km−2 yr−1, with a significant variation between basins (>100 times) closely related to the stage of agricultural intensification. Moreover, the combination of aridity and water regulation can strongly alter the final balances, not only by changing the export of nutrients by rivers (riverine export is ca. 10% for N and 8% for P in arid basins), but also decoupling the N:P ratios between terrestrial and freshwater compartments.
Quasi‐Periodic Intensification of Convective Asymmetries in the Outer Eyewall of Typhoon Lekima (2019)
Authors: Dai Huaning , Zhao Kun , Li Qingqing , Lee Wen‐Chau , Ming Jie , Zhou Ang , Fan Xueqi , Yang Zhengwei , Zheng Feng , Duan Yihong 
Published: February 2021

AbstractTyphoon Lekima (2019) possessed a double‐eyewall structure before making landfall in eastern China, with its outer eyewall showing quasi‐periodic convective intensification. Several physical mechanisms that may cause eyewall convection asymmetries were examined. The upshear occurrence of the strongest convection could not be explained by either the typhoon's motion or the effect of descending inflow from outer rainbands. Radar reflectivity analysis showed that phase locking occurred between the wavenumber‐2 vortex Rossby waves (VRWs) propagating radially outward from the inner eyewall and the azimuthally propagating wavenumber‐1 VRWs on the inner edge of the outer eyewall. Additional phase locking further arose between the aforementioned wavenumber‐1 VRWs and the azimuthally propagating wavenumber‐2 VRWs on the outer edge of the outer eyewall. These two phase‐locking processes led to the pronounced quasi‐periodic intensification of the convective asymmetry in the western semicircle of Lekima's outer eyewall.
Impact of Amazonian Fires on Atmospheric CO2
Authors: Jiang Xun , Li King‐Fai , Liang Mao‐Chang , Yung Yuk L. 
Published: February 2021

AbstractAmazon rainforest fires have significant environmental and societal impacts, but the mechanism and impact of the fires on the regional and global carbon cycles have not been fully understood. Over the rainforest, less precipitation, higher surface temperature, and enhanced mid‐tropospheric sinking air over the eastern part of the Amazon characterized the fire/dry season. These meteorological conditions will facilitate more fires in the Amazon rainforest. Using the Orbiting Carbon Observatory‐2 column CO2, we notice that there are ∼2 ppm more CO2 over the Amazon compared with the surrounding area during the fire season. The higher concentrations of atmospheric CO2 are related to the surface biomass burning, enhanced sinking air over the eastern part of the Amazon, and surface winds. Results from this study can help us better understand the carbon sources and sinks over the Amazon during the fire/dry season.
The Position of the Current Warm Period in the Context of the Past 22,000 Years of Summer Climate in China
Authors: Shi Feng , Lu Huayu , Guo Zhengtang , Yin Qiuzhen , Wu Haibin , Xu Chenxi , Zhang Enlou , Shi Jiangfeng , Cheng Jun , Xiao Xiayun , Zhao Cheng 
Published: February 2021

AbstractIdentifying the position of the Current Warm Period (CWP) in the context of the long‐term climatic trend is vital for understanding the impact of human activity on climate change. Reconstructions of summer temperature and precipitation in eight subregions of China over the past 22,000 years show that the CWP summer temperature and precipitation in these subregions are all lower than in the Early to Middle Holocene. The timing of the Holocene temperature and precipitation peaks in northern China (including Northwest China, North China, and Northeast China) is mainly determined by orbital forcing. Greenhouse gas forcing and the land ice‐sheet help to fine‐tune the timing of the climate maxima. These findings show that the climate since the Last Glacial Maximum in northern China is more sensitive to nonanthropogenic external forcings, whereas the summer precipitation in Southwest China since the early 20th century is controlled more by anthropogenically forced changes.
Turning the Orogenic Switch: Slab‐Reversal in the Eastern Alps Recorded by Low‐Temperature Thermochronology
Authors: Eizenhöfer Paul R. , Glotzbach Christoph , Büttner Lukas , Kley Jonas , Ehlers Todd A. 
Published: February 2021

AbstractMany convergent orogens, such as the eastern European Alps, display an asymmetric doubly vergent wedge geometry. In doubly vergent orogens, deepest exhumation occurs above the retro‐wedge. Deep‐seismic interpretations depict the European plate dipping beneath the Adriatic, suggesting the pro‐wedge location on the north side of the orogen. Our new thermochronometer data across the Eastern Alps confirm distinct shifts in the locus of exhumation associated with orogen‐scale structural reorganizations. Most importantly, we find a general Mid‐Miocene shift in exhumation (in the Tauern Window and the Southern Alps) and focus of modern seismicity across the Southern Alps. Taken together, these observations suggest a subduction polarity reversal at least since the Mid‐Miocene such that the present‐day pro‐wedge is located on the south side of the Alps. We propose a transient tectonic state of a slow‐and‐ongoing slab reversal coeval with motion along the Tauern Ramp, consistent with a present‐day northward migration of drainage divides.
Comment on “Tu et al., An Analytical Solution of Groundwater Flow in a Confined Aquifer With a Single Well Circulation System, Water Resources Research, First Published: 12 June 2020.”
Authors: Kabala Zbigniew J. 
Published: February 2021

AbstractAlthough renewed interest in flow around groundwater circulation wells is a positive development, the multiple and unacknowledged republication of previously published results is not. This is what has happened in a recent paper published in Water Resources Research by Tu et al. (2020, https://doi.org/10.1029/2020WR027529). The paper repeats results that appeared in Ni et al. (2011, https://doi.org/10.1016/j.applthermaleng.2011.04.030) as well as in the lead authors' own earlier work: Tu et al. (2019, https://doi.org/10.1016/j.applthermaleng.2018.09.029). And all three papers fail to acknowledge that the same ideas and closely related solutions were published in this Journal much earlier by Kabala (1993, https://doi.org/10.1029/92WR01820) and Zlotnik and Ledder (1996, https://doi.org/10.1029/95WR03813).
Helical Magnetic Cavities: Kinetic Model and Comparison With MMS Observations
Authors: Li Jing‐Huan , Zhou Xu‐Zhi , Yang Fan , Artemyev Anton V. , Zong Qiu‐Gang 
Published: February 2021

AbstractMagnetic cavities are sudden depressions of magnetic field strength widely observed in the space plasma environments, which are often accompanied by plasma density and pressure enhancement. To describe these cavities, self‐consistent kinetic models have been proposed as equilibrium solutions to the Vlasov‐Maxwell equations. However, observations from the Magnetospheric Multi‐Scale (MMS) constellation have shown the existence of helical magnetic cavities characterized by the presence of azimuthal magnetic field, which could not be reconstructed by the aforementioned models. Here, we take into account another invariant of motion, the canonical axial momentum, to construct the particle distributions and accordingly modify the equilibrium model. The reconstructed magnetic cavity shows excellent agreement with the MMS1 observations not only in the electromagnetic field and plasma moment profiles but also in electron pitch‐angle distributions. With the same set of parameters, the model also predicts signatures of the neighboring MMS3 spacecraft, matching its observations satisfactorily.
Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells
Authors: Kim Changyoun , Kwon Somin , Iba Michiyo , Spencer Brian , Rockenstein Edward , Mante Michael , Adame Anthony , Shin Soo Jean , Fields Jerel A. , Rissman Robert A. , Lee Seung-Jae , Masliah Eliezer 
Published: February 2021

AbstractSynucleinopathies are age-related neurological disorders characterized by the progressive deposition of α-synuclein (α-syn) aggregates and include Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Although cell-to-cell α-syn transmission is thought to play a key role in the spread of α-syn pathology, the detailed mechanism is still unknown. Neuroinflammation is another key pathological feature of synucleinopathies. Previous studies have identified several immune receptors that mediate neuroinflammation in synucleinopathies, such as Toll-like receptor 2 (TLR2). However, the species of α-syn aggregates varies from study to study, and how different α-syn aggregate species interact with innate immune receptors has yet to be addressed. Therefore, we investigated whether innate immune receptors can facilitate the uptake of different species of α-syn aggregates. Here, we examined whether stimulation of TLRs could modulate the cellular uptake and degradation of α-syn fibrils despite a lack of direct interaction. We observed that stimulation of TLR2 in vitro accelerated α-syn fibril uptake in neurons and glia while delaying the degradation of α-syn in neurons and astrocytes. Internalized α-syn was rapidly degraded in microglia regardless of whether TLR2 was stimulated. However, cellular α-syn uptake and degradation kinetics were not altered by TLR4 stimulation. In addition, upregulation of TLR2 expression in a synucleinopathy mouse model increased the density of Lewy-body-like inclusions and induced morphological changes in microglia. Together, these results suggest that cell type-specific modulation of TLR2 may be a multifaceted and promising therapeutic strategy for synucleinopathies; inhibition of neuronal and astroglial TLR2 decreases pathogenic α-syn transmission, but activation of microglial TLR2 enhances microglial extracellular α-syn clearance.
Relapse of pathological angiogenesis: functional role of the basement membrane and potential treatment strategies
Authors: Mukwaya Anthony , Jensen Lasse , Lagali Neil 
Published: February 2021

AbstractBlinding eye diseases such as corneal neovascularization, proliferative diabetic retinopathy, and age-related macular degeneration are driven by pathological angiogenesis. In cancer, angiogenesis is key for tumor growth and metastasis. Current antiangiogenic treatments applied clinically interfere with the VEGF signaling pathway—the main angiogenic pathway—to inhibit angiogenesis. These treatments are, however, only partially effective in regressing new pathologic vessels, and the disease relapses following cessation of treatment. Moreover, the relapse of pathological angiogenesis can be rapid, aggressive and more difficult to treat than angiogenesis in the initial phase. The manner in which relapse occurs is poorly understood; however, recent studies have begun to shed light on the mechanisms underlying the revascularization process. Hypotheses have been generated to explain the rapid angiogenic relapse and increased resistance of relapsed disease to treatment. In this context, the present review summarizes knowledge of the various mechanisms of disease relapse gained from different experimental models of pathological angiogenesis. In addition, the basement membrane—a remnant of regressed vessels—is examined in detail to discuss its potential role in disease relapse. Finally, approaches for gaining a better understanding of the relapse process are discussed, including prospects for the management of relapse in the context of disease.
Impact of the ambulatory blood pressure monitoring profile on cognitive and imaging findings of cerebral small-vessel disease in older adults with cognitive complaints
Authors: Shim Yong S. , Shin Hae-Eun 
Published: February 2021

AbstractWe investigated ambulatory blood pressure (BP) monitoring (ABPM) profiles and magnetic resonance imaging (MRI) findings of cerebral small-vessel disease (cSVD) in older adults with cognitive complaints who were grouped as follows: subjective cognitive decline, mild cognitive impairment, and dementia of Alzheimer’s type. Group comparisons and correlation analyses among demographic characteristics, cognitive and MRI findings, and ABPM profiles were performed. Furthermore, multivariate logistic regression analyses for dependent variables of (1) dementia or not and (2) MRI criteria of subcortical vascular dementia (SVaD) or not were conducted with independent variables of dichotomized ABPM profiles. A total of 174 subjects (55 males and 119 females) were included: mean age 75.36 ± 7.13 years; Mini-Mental State Examination (MMSE) score 20.51 ± 6.23. No MRI and ABPM findings except medial temporal atrophy were different between three groups. Twenty-four-hour systolic BP (sBP) was correlated with MMSE score (r = –0.182; p = 0.022) and the severity of white matter hyperintensity (WMH) (r = 0.157; p = 0.048). A higher daytime sBP was associated with dementia (odds ratio (OR): 3.734; 95% confidence interval (CI): 1.041–13.390; p = 0.043) and MRI finding of SVaD (OR: 10.543; 95% CI: 1.161–95.740; p = 0.036). Although there were no differences in ABPM profiles between three groups, a higher BP—especially a higher sBP—correlated with cognitive dysfunction and severity of WMH in older adults. Only higher daytime sBP was an independent predictor for dementia and MRI findings of SVaD. Among various ABPM profiles in this study, a higher BP, especially a higher sBP, may be considered the most important for clinical and MRI findings of cSVD.
Intercellular mitochondrial transfer as a means of tissue revitalization
Authors: Liu Delin , Gao Youshui , Liu Jiao , Huang Yigang , Yin Junhui , Feng Yuyao , Shi Linjing , Meloni Bruno P. , Zhang Changqing , Zheng Minghao , Gao Junjie 
Published: February 2021

AbstractAs the crucial powerhouse for cell metabolism and tissue survival, the mitochondrion frequently undergoes morphological or positional changes when responding to various stresses and energy demands. In addition to intracellular changes, mitochondria can also be transferred intercellularly. Besides restoring stressed cells and damaged tissues due to mitochondrial dysfunction, the intercellular mitochondrial transfer also occurs under physiological conditions. In this review, the phenomenon of mitochondrial transfer is described according to its function under both physiological and pathological conditions, including tissue homeostasis, damaged tissue repair, tumor progression, and immunoregulation. Then, the mechanisms that contribute to this process are summarized, such as the trigger factors and transfer routes. Furthermore, various perspectives are explored to better understand the mysteries of cell–cell mitochondrial trafficking. In addition, potential therapeutic strategies for mitochondria-targeted application to rescue tissue damage and degeneration, as well as the inhibition of tumor progression, are discussed.
Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors
Authors: Aslanoglou Despoina , Bertera Suzanne , Sánchez-Soto Marta , Benjamin Free R. , Lee Jeongkyung , Zong Wei , Xue Xiangning , Shrestha Shristi , Brissova Marcela , Logan Ryan W. , Wollheim Claes B. , Trucco Massimo , Yechoor Vijay K. , Sibley David R. , Bottino Rita , Freyberg Zachary 
Published: February 2021

AbstractDopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central nervous system that also act in the pancreas as peripheral regulators of metabolism. Pancreatic catecholamine signaling has also been increasingly implicated as a mechanism responsible for the metabolic disturbances produced by antipsychotic drugs (APDs). Critically, however, the mechanisms by which catecholamines modulate pancreatic hormone release are not completely understood. We show that human and mouse pancreatic α- and β-cells express the catecholamine biosynthetic and signaling machinery, and that α-cells synthesize DA de novo. This locally-produced pancreatic DA signals via both α- and β-cell adrenergic and dopaminergic receptors with different affinities to regulate glucagon and insulin release. Significantly, we show DA functions as a biased agonist at α2A-adrenergic receptors, preferentially signaling via the canonical G protein-mediated pathway. Our findings highlight the interplay between DA and NE signaling as a novel form of regulation to modulate pancreatic hormone release. Lastly, pharmacological blockade of DA D2-like receptors in human islets with APDs significantly raises insulin and glucagon release. This offers a new mechanism where APDs act directly on islet α- and β-cell targets to produce metabolic disturbances.
Intravenous and subcutaneous formulations of trastuzumab, and trastuzumab biosimilars: implications for clinical practice
Authors: Waller Cornelius F. , Möbius Julia , Fuentes-Alburo Adolfo 
Published: February 2021

AbstractTrastuzumab is a biologic therapy indicated for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer and metastatic gastric cancer. Trastuzumab was originally approved as an intravenous (IV) formulation but has since been developed for subcutaneous (SC) administration for patients with HER2-positive breast cancer. Both formulations demonstrate generally comparable pharmacological and clinical profiles. Therefore, when deciding between treatment options, factors such as the route of administration, patient preference, value and cost must be considered. Studies comparing IV with SC trastuzumab indicate that each formulation offers unique advantages to patients depending on their individual needs. Concurrent with the development of SC trastuzumab, IV trastuzumab biosimilars comprise another treatment option that, in view of their reduced cost, might improve patient access and increase cost-effectiveness for healthcare providers and payers. In this review, we seek to raise awareness of the current options available for trastuzumab so that healthcare providers can optimally treat patients according to their individual situations and preferences.