bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time-Varying Risk Aversion and Inflation-Consumption Correlation in an Equilibrium Term Structure Model
Authors: Bletzinger Tilman , Lemke Wolfgang , Renne Jean-Paul 
Published: December 2024

Abstract
Inflation risk premiums tend to be positive in an economy mainly hit by supply shocks, and negative if demand shocks dominate. Risk premiums also fluctuate with risk aversion. We shed light on this nexus in a linear-quadratic equilibrium macro-finance model featuring time variation in inflation-consumption correlation and risk aversion. We obtain analytical solutions for real and nominal yield curves and for risk premiums. While changes in the inflation-consumption correlation drive nominal yields, changes in risk aversion drive real yields and act as amplifier on nominal yields. Combining a trend-cycle specification of real consumption with hysteresis effects generates an upward-sloping real yield curve. Estimating the model on U.S. data from 1961 to 2019 confirms substantial time variation in inflation risk premiums: distinctly positive in the earlier part of our sample, especially during the 1980s, and turning negative with the onset of the new millennium.
DNAJC12 downregulation induces neuroblastoma progression via increased histone H4K5 lactylation
Authors: Yang Yaqi , Wen Jiejun , Lou Susu , Han Yali , Pan Yi , Zhong Ying , He Qiao , Zhang Yinfeng , Mo Xi , Ma Jing , Shen Nan 
Published: December 2024

Abstract
Neuroblastoma (NB) is the most common extracranial solid tumor in children. Despite treatment advances, the survival rates of high-risk NB patients remain low. This highlights the urgent need for a deeper understanding of the molecular mechanisms driving NB progression to support the development of new therapeutic strategies. In this study, we demonstrated that the reduced levels of DNAJC12, a protein involved in metabolic regulation, are associated with poor prognosis in NB patients. Our data indicate that low DNAJC12 expression activates glycolysis in NB cells, leading to increased lactic acid production and histone H4 lysine 5 lactylation (H4K5la). Elevated H4K5la upregulates the transcription of COL1A1, a gene implicated in cell metastasis. Immunohistochemistry staining of NB patient samples confirmed that high H4K5la levels correlate with poor clinical outcomes. Furthermore, we showed that inhibiting glycolysis, reducing H4K5la, or targeting COL1A1 can mitigate the invasive behavior of NB cells. These findings reveal a critical link between metabolic reprogramming and epigenetic modifications in the context of NB progression, suggesting that H4K5la could serve as a novel diagnostic and prognostic marker, and shed light on identifying new therapeutic targets within metabolic pathways for the treatment of this aggressive pediatric cancer.
A Bayesian approach to model local and temporal heterogeneity in repeated cross-sectional health surveys
Authors: Stival Mattia , Schiavon Lorenzo , Campostrini Stefano 
Published: December 2024

Abstract
In several countries, including Italy, a prominent approach to population health surveillance involves conducting repeated cross-sectional surveys at short intervals of time. These surveys gather information on the health status of individual respondents, including details on their behaviours, risk factors, and relevant socio-demographic information. While the collected data provides valuable information, modelling such data presents several challenges. For instance, in health risk models, it is essential to consider behavioural information, local and temporal dynamics, and disease co-occurrence. In response to these challenges, our work proposes a multivariate temporal logistic model for chronic disease diagnoses at local level. Linear predictors are modelled using individual risk factor covariates and a latent individual propensity to diseases. Leveraging a state space formulation of the model, we construct a framework in which temporal heterogeneity in regression coefficients is informed by exogenous information at local level, corresponding to different contextual risk factors that may affect the occurrence of chronic diseases in different ways. To explore the effectiveness of our method, we analyse behavioural and risk factor surveillance data collected in Italy (PASSI), which is well-known as a country characterized by high peculiar administrative, social and territorial diversities reflected on high variability in morbidity among population subgroups.
Tense logics based on posets
Authors: Chajda Ivan , LÄnger Helmut , Ledda Antonio , Paseka Jan , Vergottini Gandolfo 
Published: December 2024

Abstract
Quantum mechanics, initially formalized with orthomodular lattices, benefits from a simpler approach using just partially ordered sets (posets). This paper explores how logical connectives are introduced in poset-based logics. Building on prior work by the authors, we delve deeper into ‘dynamic’ logics where truth values can change over time. We consider time sets with a preference relation and propositions whose truth depends on time. Tense operators, introduced by J.Burgess and extended for various logics, become a valuable tool. This paper proposes several approaches to this topic, aiming to inspire a further stream of research.
ExoMol line lists – LXI. A trihybrid line list for rovibronic transitions of the hydroxyl radical (OH)
Authors: Mitev Georgi B , Bowesman Charles A , Zhang Jingxin , Yurchenko Sergei N , Tennyson Jonathan 
Published: December 2024

ABSTRACT
The hydroxyl radical (OH) is a species of high importance in exoplanetary studies, the interstellar medium, and in stellar spectra. Terrestrially, it is a significant component of combustion chemistry, an oxidizer in the upper atmosphere, and a source of telluric bands. Internally contracted multireference configuration interaction potential energy curves, spin-orbit couplings, electronic angular momentum couplings, and (transition) dipole moments for eight electronic states of OH are computed and refined against empirical energy levels to produce an OH spectroscopic model. A line list consisting of rovibronic term values, allowed electronic dipole transitions, Einstein-A coefficients, and partition functions for varying temperature and a continuum absorption data set are then produced by variational solution of the coupled-channel Schrödinger equations using the nuclear motion code Duo. Marvel energy levels substitute equivalent levels in the OH line list, with estimated uncertainties in experimentally dark regions, following an established hybridization procedure. Predissociation lifetimes of the A $^2\Sigma ^+$ state are calculated using a stabilization method and convoluted with natural lifetimes to include predissociative effects. Continuum absorption cross-sections for $T \in [100,200,...,8000]~\textrm {K}$ and zero pressure are provided in the range of $0\rightarrow 80\, 000$ cm$^{-1}$ with a step size of 0.01 cm$^{-1}$. Comparison with available literature cross-sections exhibits strong agreement. The line list is suitable for high-resolution studies up to 8000 K. The OH MYTHOS data set is available for download via www.exomol.com.
A de novo Gene Promotes Seed Germination Under Drought Stress in Arabidopsis
Authors: Jin Guang-Teng , Xu Yong-Chao , Hou Xing-Hui , Jiang Juan , Li Xin-Xin , Xiao Jia-Hui , Bian Yu-Tao , Gong Yan-Bo , Wang Ming-Yu , Zhang Zhi-Qin , Zhang Yong E , Zhu Wang-Sheng , Liu Yong-Xiu , Guo Ya-Long 
Published: December 2024

Abstract
The origin of genes from noncoding sequences is a long-term and fundamental biological question. However, how de novo genes originate and integrate into the existing pathways to regulate phenotypic variations is largely unknown. Here, we selected 7 genes from 782 de novo genes for functional exploration based on transcriptional and translational evidence. Subsequently, we revealed that Sun Wu-Kong (SWK), a de novo gene that originated from a noncoding sequence in Arabidopsis thaliana, plays a role in seed germination under osmotic stress. SWK is primarily expressed in dry seed, imbibing seed and silique. SWK can be fully translated into an 8 kDa protein, which is mainly located in the nucleus. Intriguingly, SWK was integrated into an extant pathway of hydrogen peroxide content (folate synthesis pathway) via the upstream gene cytHPPK/DHPS, an Arabidopsis-specific gene that originated from the duplication of mitHPPK/DHPS, and downstream gene GSTF9, to improve seed germination in osmotic stress. In addition, we demonstrated that the presence of SWK may be associated with drought tolerance in natural populations of Arabidopsis. Overall, our study highlights how a de novo gene originated and integrated into the existing pathways to regulate stress adaptation.
Ectopic endometrial stromal cell-derived extracellular vesicles encapsulating microRNA-25-3p induce endometrial collagen I deposition impairing decidualization in endometriosis
Authors: Zhu Yuan , Zheng Bo , Zhang Yuting , Li Mengyun , Jiang Yuan , Zhou Jidong , Zhang Yang , Kang Nannan , Wu Min , Yan Yuan , Xing Jun , Zhou Jianjun 
Published: December 2024

Abstract
Endometrial collagen I undergoes dynamic degradation and remodelling in response to endometrial stromal cell (ESC) decidualization and embryo implantation. However, excessive collagen I deposition in the endometrium during the implantation window may impair decidualization, causing embryo implantation failure in patients with endometriosis (EMS). We found that endometrial collagen I expression during the mid-secretory phase was increased in the EMS group of patients. Collagen I stimulation resulted in decreased expression of the decidualization markers prolactin and insulin-like growth factor binding protein-1 in ESCs, impeding ESC transformation to a decidual morphology and decreasing the blastocyst-like spheroid expansion area in vitro. Treatment with extracellular vesicles (EVs) derived from the ectopic ESCs of EMS patients (EMS-EVs) increased collagen I expression in vivo and in vitro and decreased the blastocyst-like spheroid expansion area. Furthermore, EV microRNA (miRNA) sequencing revealed that there were 40 upregulated and 77 downregulated miRNAs in EMS-EVs when compared to the EVs derived from ESCs in the endometrium of control patients (CTL-EVs), including increased expression of miR-25-3p that targets phosphatase and tensin homolog (PTEN). We also found that PTEN expression was decreased and p-Akt expression was increased in the endometrium of EMS patients and EMS-EV-treated ESCs. miR-25-3p transfected ESCs exhibited increased collagen I, decreased PTEN, and increased p-Akt. Additionally, an EV uptake study further showed that EMS-EVs were preferentially taken up by ESCs rather than by endometrial epithelial cells. These results suggest that EMS-EVs encapsulating miR-25-3p might be preferentially taken up by eutopic ESCs where they may induce endometrial collagen I deposition to impair ESC decidualization in EMS.
A subcellular selective APEX2-based proximity labeling used for identifying mitochondrial G-quadruplex DNA binding proteins
Authors: Wang Xu , Qin Geng , Yang Jie , Zhao Chuanqi , Ren Jinsong , Qu Xiaogang 
Published: December 2024

Abstract
G-quadruplexes (G4s), as an important type of non-canonical nucleic acid structure, have received much attention because of their regulations of various biological processes in cells. Identifying G4s-protein interactions is essential for understanding G4s-related biology. However, current strategies for exploring G4 binding proteins (G4BPs) include pull-down assays in cell lysates or photoaffinity labeling, which are lack of sufficient spatial specificity at the subcellular level. Herein, we develop a subcellular selective APEX2-based proximity labeling strategy to investigate the interactome of mitochondrial DNA (mtDNA) G4s in living cells. By this method, we have identified several mtDNA G4BPs. Among them, a previously unrecognized mtDNA G4BP, DHX30 has been selected as an example to explore its important biofunctions. DHX30 localizes both in cytoplasm and mitochondria and can resolve mtDNA G4s. Further studies have demonstrated that DHX30 unfolds mtDNA G4 in living cells, which results in a decrease in glycolysis activity of tumor cells. Besides, RHPS4, a known mtDNA G4 stabilizer, will reverse this inhibition effect. Benefiting from the high spatiotemporal resolution and the ability of genetically encoded systems to perform the labeling with exquisite specificity within living cells, our approach can realize the identification of subcellular localized G4BPs. Our work provides a novel strategy to map protein interactions of specific nucleic acid features in subcellular compartments of living cells.
Tobacco Susceptibility and Use Among Rural Adolescents: The Role of Tobacco Marketing Exposure and Screen Media Use
Authors: Kim Sunny Jung , Fugate-Laus Kendall , Barsell Jeremy , Do Elizabeth K , Hayes Rashelle B , Fuemmeler Bernard F 
Published: December 2024

Abstract

Introduction
Tobacco marketing has been found to increase pro-tobacco attitudes and susceptibilities; yet its impact on rural adolescents lacks research. We aim to examine the association between tobacco marketing exposure, screen use, and susceptibility and use of tobacco among a rural youth sample.

Aims and Methods
Youth (N = 697) enrolled in grades 9–11 that resided in rural counties in Virginia were recruited to participate in a survey in September 2022. We assessed demographics, tobacco use, susceptibility to tobacco use, screen media use, and exposure to tobacco marketing and warning messages.

Results
One in five (n = 144, 20.66%) participants reported using any tobacco products and 394 (56.53%) indicated susceptibility. High engagement in social media and texting were more likely to be tobacco ever users than those who had low engagement with those screen media, X2(1) = 12.00 and X2(1) = 19.40, respectively (ps &lt; .001). Greater exposure to pro-tobacco marketing on social media (odds ratio [OR]: 2.03, 95% CI [1.37 to 3.03]) and higher-grade level (OR: 1.77, 95% CI [1.29 to 2.43]) were significantly associated with a greater likelihood of reporting “ever-use” of tobacco products, while controlling for mother’s education, gender, and ethnicity. Among adolescents who never used tobacco products, a higher grade level was associated with greater susceptibility to initiating tobacco product use (OR: 1.40, 95% CI [1.05 to 1.86]).

Conclusions
In this rural sample, greater social media/text use and exposure to pro-tobacco marketing on social media were significantly associated with tobacco ever use. Identification of these risk factors can help inform potential targets and timing for future tobacco prevention campaigns for rural youth.

Implications
Screen media use, tobacco marketing/warning exposure, and their associations with tobacco use and susceptibility were examined in a study with 697 rural Virginia youth. Heavy social media/text users were more likely to have used tobacco products. Exposure to tobacco marketing on social media and higher grade levels were associated with ever using tobacco. Higher grade levels were linked to increased susceptibility to tobacco use among nonusers. These results highlight the importance of resilience to pro-tobacco marketing on social media, and self-regulation of social media/text use in interventions for tobacco ever users. Early interventions may benefit rural youth who never used tobacco.
Timing of Infection as a Key Driver of Racial/Ethnic Disparities in Coronavirus Disease 2019 Mortality Rates During the Prevaccine Period
Authors: Naraharisetti Ramya , Trangucci Rob , Sakrejda Krzysztof , Masters Nina B , Malosh Ryan , Martin Emily T , Eisenberg Marisa , Link Bruce , Eisenberg Joseph N S , Zelner Jon 
Published: December 2024

Abstract
Disparities in coronavirus disease 2019 mortality are driven by inequalities in group-specific incidence rates (IRs), case fatality rates (CFRs), and their interaction. For emerging infections, such as severe acute respiratory syndrome coronavirus 2, group-specific IRs and CFRs change on different time scales, and inequities in these measures may reflect different social and medical mechanisms. To be useful tools for public health surveillance and policy, analyses of changing mortality rate disparities must independently address changes in IRs and CFRs. However, this is rarely done. In this analysis, we examine the separate contributions of disparities in the timing of infection—reflecting differential infection risk factors such as residential segregation, housing, and participation in essential work—and declining CFRs over time on mortality disparities by race/ethnicity in the US state of Michigan. We used detailed case data to decompose race/ethnicity-specific mortality rates into their age-specific IR and CFR components during each of 3 periods from March to December 2020. We used these estimates in a counterfactual simulation model to estimate that that 35% (95% credible interval, 30%–40%) of deaths in black Michigan residents could have been prevented if these residents were infected along the timeline experienced by white residents, resulting in a 67% (61%–72%) reduction in the mortality rate gap between black and white Michigan residents during 2020. These results clearly illustrate why differential power to “wait out” infection during an infectious disease emergency—a function of structural racism—is a key, underappreciated, driver of inequality in disease and death from emerging infections.
The Caregiver Pathway Intervention Can Contribute to Reduced Post-Intensive Care Syndrome Among Family Caregivers of ICU Survivors: A Randomized Controlled Trial
Authors: Watland Solbjørg , Solberg Nes Lise , Ekeberg Øivind , Rostrup Morten , Hanson Elizabeth , Ekstedt Mirjam , Stenberg Una , Hagen Milada , Børøsund Elin 
Published: December 2024

Objectives:
Explore short-term effects of “The Caregiver Pathway,” an intervention for family caregiver follow-up, on Post-Intensive Care Syndrome symptoms among families (PICS-F).

Design:
A randomized controlled trial.

Setting:
A medical ICU at a Norwegian University Hospital.

Participants:
One hundred ninety-six family caregivers of critically ill patients randomized to an intervention (n = 101) or control group (n = 95).

Interventions:
“The Caregiver Pathway” four-step model offers individual and structured follow-up, including: 1) mapping family caregivers’ needs and concerns with an assessment tool followed by a conversation with an ICU nurse within the first days at the ICU, 2) a supportive card when leaving the ICU, 3) offer for the family caregivers to receive a phone call after ICU patient discharge, and 4) a follow-up conversation within 3 months.

Measurements and Main Results:
Data were collected at baseline and after 3 months and analyzed using linear regression. No significant effects were detected when comparing all participants completing 3-month outcome measurements (n = 144). A subgroups analysis stratified on patient survival, however, showed statistically significant effect for family caregivers of patients surviving the ICU stay receiving the intervention compared with controls. Caregivers of surviving patients reported improved symptoms related to post-traumatic stress disorder, measured by Impact of Event Scale-Revised (B = –8.2 [95% CI, –14.2 to –2.2]; p = 0.008), anxiety (B = –2.2 [95% CI, –4.0 to –0.5]; p = 0.014), and depression (B = –1.5 [95% CI, –2.9 to –0.1]; p = 0.035); measured by the Hospital Anxiety and Depression Scale, subscore physical functioning in health-related quality of life (B = 9.7 [95% CI, 0.3–19.0]; p = 0.043); measured by Short Form 12-Item Health Survey; and hope (B = 2.4 [95% CI, 0.4–4.3]; p = 0.017) and measured by the Herth Hope Index. At 3-month, the model did not appear to improve the outcomes for family caregivers of nonsurviving patients.

Conclusions:
“The Caregiver Pathway” intervention was associated with reduced symptoms of PICS-F in family caregivers of surviving ICU patients compared with controls.
Metastastic Tumors to the Lacrimal Gland from Distant Primary Cancer
Authors: Mombaerts Ilse , Rana Khizar , Verity David H. , Malhotra Raman , Poh Eugenie W. T. , Selva Dinesh 
Published: December 2024

Purpose:
To characterize the clinical, radiological, and pathological features of patients with metastases to the lacrimal gland from distant primaries.

Methods:
Multicentre retrospective case series and a review of the literature of cases of metastases to the lacrimal gland.

Results:
We present 4 cases of lacrimal gland metastases, with the primaries being renal cell (n = 2) and breast (n = 2) carcinoma. The literature review identified 40 additional cases (19 male, mean age, range 21–84 years) of lacrimal gland metastasis. Based on these 44 cases, including 4 from the present study, 2 patterns of metastasis were identified: 23 cases (52.3%, 23/44) with lacrimal gland enlargement without bony erosion, and 21 cases (47.7%, 21/44) with associated bony erosion of the superolateral orbit of whom 12 (57.1%, 12/21) had intracranial extension. The most common primary for lacrimal gland metastasis without bony erosion was breast cancer (56.5%, 13/23), whereas hepatocellular carcinoma was the most common cause of lacrimal gland metastasis with bony erosion (52.4%, 11/21). Lacrimal gland metastasis was the first presentation of cancer in 15 cases (34.1%, 15/44) and was the first presentation of metastasis in 12 cases (27.3%, 12/44).

Conclusions:
Metastasis to the lacrimal gland is a potential cause of lacrimal gland enlargement. It may be the initial sign of distal occult cancer or occult metastatic disease. Different patterns of metastasis may be seen with different underlying primaries.
Relationship Between the Pain Intensity at the Time of the Hamstring Muscle Injury and the Hyperintense T2 Weighted Volume of the Hamstring Muscle Lesion Measured by MRI
Authors: Grange Sylvain , Plancher Ronan , Reurink Gustaav , Croisille Pierre , Edouard Pascal 
Published: December 2024

Objectives:
The primary objective of this study was to analyze the correlation between the pain experienced at the time of a hamstring muscle injury and the hyperintense T2 weighted volume of the lesion measured on MRI. The secondary objectives were to analyze the differences in this pain with the lesion grade and the hamstring muscle head involved.

Design:
We performed a retrospective analysis of the data collected in a prospective, multicenter, noninterventional cohort study (HAMMER).

Patients:
A total of 61 patients were included in this analysis.

Interventions:
Patients with suspected hamstring muscle injury had an MRI after the injury.

Main outcomes measures:
They were evaluated for their pain intensity experienced at the time of injury with a Numeric Pain Rating Scale (NPRS) from 0 to 10.

Results:
There was a significant but weak correlation between the pain experienced at the time of hamstring muscle injury and the hyperintense T2 weighted volume (r = 0.287; P = 0.025). There were no significant differences in the pain according to the lesion grade (F(3,57) = 0.982; P = 0.408) nor according to the muscle involved (F(3,57) = 1.013; P = 0.394).

Conclusions:
Pain at the time of injury seemed to be weakly correlated with the extent of muscle lesion at medical imaging. Pain at the time of injury alone seems not enough to give us a clinical meaningful indication of the MRI hyperintense T2 weighted volume.