bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum Metabolic Profiling Analysis of Chronic Gastritis and Gastric Cancer by Untargeted Metabolomics
Authors: Yu Lin , Lai Qinhuai , Feng Qian , Li Yuanmeng , Feng Jiafu , Xu Bei 
Published: March 2021

PurposeGastric cancer is a common tumor of the digestive system. Identification of potential molecules associated with gastric cancer progression and validation of potential biomarkers for gastric cancer diagnosis are very important. Thus, the aim of our study was to determine the serum metabolic characteristics of the serum of patients with chronic gastritis (CG) or gastric cancer (GC) and validate candidate biomarkers for disease diagnosis.Experimental DesignA total of 123 human serum samples from patients with CG or GC were collected for untargeted metabolomic analysis via UHPLC-Q-TOF/MS to determine characteristics of the serum. Principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), and heat map were used for multivariate analysis. In addition, commercial databases were used to identify the pathways of metabolites. Differential metabolites were identified based on a heat map with a t-test threshold (p &lt; 0.05), fold-change threshold (FC &gt; 1.5 or FC &lt; 2/3) and variable importance in the projection (VIP &gt;1). Then, differential metabolites were analyzed by receiver operating characteristic (ROC) curve to determine candidate biomarkers. All samples were analyzed for fasting lipid profiles.ResultsAnalysis of serum metabolomic profiles indicated that most of the altered metabolic pathways in the three groups were associated with lipid metabolism (p &lt; 0.05) and lipids and lipid-like molecules were the predominating metabolites within the top 100 differential metabolites (p &lt; 0.05, FC &gt; 1.5 or FC &lt; 2/3, and VIP &gt;1). Moreover, differential metabolites, including hexadecasphinganine, linoleamide, and N-Hydroxy arachidonoyl amine had high diagnostic performance according to PLS-DA. In addition, fasting lipid profile analysis showed the serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A1 (Apo-A1) were decreased concomitant to the progression of the progression of the disease compared with those in the control group (p &lt; 0.05).ConclusionsThus, this study demonstrated that lipid metabolism may influence the development of CG to GC. Hexadecasphinganine, linoleamide, and N-Hydroxy arachidonoyl amine were selected as candidate diagnostic markers for CG and GC.
Disturbed Blood Flow Acutely Increases Endothelial Microparticles and Decreases Flow Mediated Dilation in Patients With Heart Failure With Reduced Ejection Fraction
Authors: Silva Thiago O. C. , Sales Allan R. K. , Araujo Gustavo S. M. , Fonseca Guilherme W. P. , Braga Pedro G. S. , Faria Diego , Rocha Helena N. M. , Rocha Natalia G. , Lima Marta F. , Mady Charles , Negrão Carlos E. , Alves Maria Janieire N. N. 
Published: March 2021

IntroductionDisturbed blood flow, characterized by high retrograde and oscillatory shear rate (SR), is associated with a proatherogenic phenotype. The impact of disturbed blood flow in patients with heart failure with reduced ejection fraction (HFrEF) remains unknown. We tested the hypothesis that acute elevation to retrograde and oscillatory SR provoked by local circulatory occlusion would increase endothelial microparticles (EMPs) and decrease brachial artery flow-mediated dilation (FMD) in patients with HFrEF.MethodsEighteen patients with HFrEF aged 55 ± 2 years, with left ventricular ejection fraction (LVEF) 26 ± 1%, and 14 control subjects aged 49 ± 2 years with LVEF 65 ± 1 randomly underwent experimental and control sessions. Brachial artery FMD (Doppler) was evaluated before and after 30 min of disturbed forearm blood flow provoked by pneumatic cuff (Hokanson) inflation to 75 mm Hg. Venous blood samples were collected at rest, after 15 and 30 min of disturbed blood flow to assess circulating EMP levels (CD42b−/CD31+; flow cytometry).ResultsAt rest, FMD was lower in patients with HFrEF compared with control subjects (P &lt; 0.001), but blood flow patterns and EMPs had no differences (P &gt; 0.05). The cuff inflation provoked a greater retrograde SR both groups (P &lt; 0.0001). EMPs responses to disturbed blood flow significantly increased in patients with HFrEF (P = 0.03). No changes in EMPs were found in control subjects (P &gt; 0.05). Disturbed blood flow decreased FMD both groups. No changes occurred in control condition.ConclusionCollectively, our findings suggest that disturbed blood flow acutely decreases FMD and increases EMP levels in patients with HFrEF, which may indicate that this set of patients are vulnerable to blood flow disturbances.
REFOCUS-PULSAR Recovery-Oriented Practice Training in Adult Primary Mental Health Care: Exploratory Findings Including From a Pretest–Posttest Evaluation
Authors: Enticott Joanne C. , Shawyer Frances , Brophy Lisa Mary , Russell Grant , Mazza Danielle , Wilson-Evered Elisabeth , Weller Penelope June , Slade Mike , Edan Vrinda , Meadows Graham Nicholas 
Published: March 2021

Objectives:Australian general practitioners (GPs) are pivotal in mental health care. The REFOCUS-PULSAR (Principles Unite Local Services Assisting Recovery) primary care study aimed to improve personal recovery outcomes in adults with mental health problems consulting GPs.Design:Modified from an intended stepped-wedge cluster study, an exploratory (pre- and post-intervention) design employed cross-sectional surveys of patients consulting GPs.Setting:Eighteen primary care sites (clusters) in Victoria, Australia in 2013–2017.Participants:From 30 GPs recruited, 23 participated (76%), with 235 patient surveys returned from adults aged &lt;75 years receiving mental health care.Intervention:A co-delivered face-to-face training intervention for GPs in recovery-oriented practice (ROP), with personal recovery a key focus, used multimedia, mnemonics, and targeted interview schedules to encourage ROP—with availability of support sessions for 1 year.Outcome Measures:Primary: the Questionnaire about the Process of Recovery full-scale score (outcome). Secondary: INSPIRE (experience), Warwick-Edinburgh Mental Well-being Scale (WEMWBS) and Kessler Psychological Distress Scale (K10) (outcomes). Other: General-practice-Users Perceived-need Inventory (experience).Results:Small positive significant effects indicated primary-outcome post-intervention improvements [t-test (233) = −2.23,p= 0.01], also improvement in two secondary outcomes (WEMWBSt(233) = −2.12,p= 0.02 and K10t(233) = 2.44,p= 0.01). More patients post-intervention reported “no need” for further help from their GP; but in those reporting needs, there was greater unmet need for counseling.Conclusions:ROP implementation, internationally influential in specialist mental health care, here is explored in primary care where it has had less attention. These exploratory findings suggest better patient outcomes followed introducing GPs to ROP in routine practice conditions. Higher unmet need for counseling post-intervention reported by patients might be a sign of limited supply despite ROP facilitating better identification of needs. Challenges in project implementation means that these findings carry risks of bias and flag the importance establishing research infrastructure in primary care.Clinical Trial Registration:www.clinicaltrials.gov/, The Australian and New Zealand Clinical Trial Registry Identifier: ACTRN12614001312639.
Effects of Lean Thinking and Emerging Technologies on Breast Cancer Patients' Therapeutic Process During COVID-19 Pandemic: A Case-Control Matched Study
Authors: Pellini Francesca , Di Filippo Giacomo , Mirandola Sara , Deguidi Giulia , Filippi Elisa , Pollini Giovanni Paolo 
Published: March 2021

Introduction: The advent of the COVID-19 pandemic has led to the sudden disruption of routine medical care, and the subsequent reorganization of hospital structures and therapeutic algorithms, aiming at protecting patients and health professionals. This was inevitably bound to affect our Breast Unit, dilating both pre- and post-operative times. The aim of this study was to evaluate the effect on patients' flow of organizational and logistic changes (key interventions) based on lean thinking implemented after the COVID-19 outbreak.Materials and Methods: Clinical and demographic data were retrospectively collected from patients undergoing sentinel lymph node biopsy for breast cancer at the Verona University Hospital from January 2018 to June 2020. Patients enrolled (n = 341) were divided into two groups according to date of admission: before (Group A; n = 294) and after (Group B; n = 47) the implementation of key interventions. Each case in Group B was subsequently matched 1:1 by means of case-control matching with cases from Group A for age, comorbidities, and type of surgery (Subgroup A1; N = 47). Pre-admission time (T0) and length of stay (T1) were compared between the three groups.Results: Median T0 was 312 h, whereas median T1 was 24 h. Patients in Group B had a higher frequency of comorbidities (57.4 vs. 25.2%, p = 0.001) and underwent mastectomy more often than patients in Group A (61.7 vs. 36.7%, p = 0.001). Both median T0 and T1 were higher in group B than in group A (384 vs. 300 h, p = 0.001, 48 vs. 24 h, p = 0.001, respectively). Median T0 and T1 did not significantly differ between Group B and Subgroup A1 (all p &gt; 0.05).Conclusions: Lean thinking and new technologies could prove useful to the optimization of preoperative and postoperative times during the current pandemic, minimizing healthcare personnel and patients' exposure to SARS-CoV-2, and promoting a rational use of limited resources, while complying with oncological principles.
Association of Baseline Urinary Metabolic Biomarkers with ADPKD Severity in TAME-PKD Clinical Trial Participants
Authors: Hallows Kenneth R. , Althouse Andrew D. , Li Hui , Saitta Biagio , Abebe Kaleab Z. , Bae Kyongtae T. , Miskulin Dana C. , Perrone Ronald D. , Seliger Stephen L. , Watnick Terry J. 
Published: March 2021

Key Points

Urine excretion of two key glycolytic enzymes correlated with autosomal dominant polycystic kidney disease (ADPKD) severity (height-adjusted total kidney volume and eGFR) at baseline in the TAME-PKD study population.These findings are the first to provide evidence in human urine samples that upregulated glycolytic flux is a feature of ADPKD severity.Future analyses will test whether metformin affects ADPKD disease progression and urinary metabolic biomarkers in patients during the study.

Background
Recent work suggests that dysregulated cellular metabolism may play a key role in the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD). The TAME-PKD clinical trial is testing the safety, tolerability, and efficacy of metformin, a regulator of cell metabolism, in patients with ADPKD. This study investigates the cross-sectional association of urinary metabolic biomarkers with ADPKD severity among TAME-PKD trial participants at baseline.

Methods
Concentrations of total protein, targeted metabolites (lactate, pyruvate, succinate, and cAMP), and key glycolytic enzymes (pyruvate kinase M2 [PKM2], lactate dehydrogenase A [LDHA], and pyruvate dehydrogenase kinase 1 [PDK1]) were measured by ELISA, enzymatic assays, and immunoblotting in baseline urine specimens of 95 TAME-PKD participants. These analytes, normalized by urinary creatinine or osmolality to estimate excretion, were correlated with patients’ baseline height-adjusted total kidney volumes (htTKVs) by MRI and eGFR. Additional analyses were performed, adjusting for participants’ age and sex, using multivariable linear regression.

Results
Greater htTKV correlated with lower eGFR (r=−0.39; P=0.0001). Urinary protein excretion modestly correlated with eGFR (negatively) and htTKV (positively). Urinary cAMP normalized to creatinine positively correlated with eGFR. Among glycolytic enzymes, PKM2 and LDHA excretion positively correlated with htTKV, whereas PKM2 excretion negatively correlated with eGFR. These associations remained significant after adjustments for age and sex. Moreover, in adjusted models, succinate excretion was positively associated with eGFR, and protein excretion was more strongly associated with both eGFR and htTKV in patients <43 years old.

Conclusions
Proteinuria correlated with ADPKD severity, and urinary excretion of PKM2 and LDHA correlated with ADPKD severity at baseline in the TAME-PKD study population. These findings are the first to provide evidence in human urine samples that upregulated glycolytic flux is a feature of ADPKD severity. Future analysis may reveal if metformin treatment affects both disease progression and the various urinary metabolic biomarkers in patients throughout the study.
Thermal stability and polymorphic transformation kinetics in β-MnTe films deposited via radiofrequency magnetron sputtering
Authors: Mori Shunsuke , Hatayama Shogo , Ando Daisuke , Sutou Yuji 
Published: March 2021

Abstract
A manganese telluride (MnTe) compound is an interesting polymorphic semiconductor with physical properties differing greatly among various polymorphs. In this study, the thermal stability and polymorphic transformation kinetics in β-MnTe films obtained via radiofrequency magnetron sputtering were investigated. The obtained MnTe films with a composition range of 50.5–46.1 at.% Te exhibited a single β phase. The polymorphic transformation temperature from the β (wurtzite-type) to an α (NiAs-type) phase decreased with increasing the Te content. In the non-isothermal analysis using differential scanning calorimetry, the activation energy for β → α transformation was measured to be 1.41 eV, based on Kissinger plots. The retention time of β-MnTe was also investigated via the Ozawa method, and it was estimated to be retained for 4.5 × 109 years at 25 °C. The estimated Avrami exponent of 3.5 indicated that two- and three-dimensional growth at a constant nucleation rate was dominant at the intermediate stage of β → α transformation.
Public Participation and the Governance of Mineral Resources in Zimbabwe
Authors: Chikova Rangarirai , Chilunjika Alouis 
Published: March 2021

Public participation in policy issues by the locals is a crucial ingredient that guarantees the success of any policy decision, national project and public programme. Public participation should permeate every sphere of governance. In this vein, Zimbabwe is endowed with numerous mineral resources. The indigenous Zimbabwean are statutorily deemed as the owners of the mineral resources hence their participation in policy processes and spaces that relate to the governance of natural resources is pertinent. However, it was noted that the Zimbabwean population is not fully benefiting from the extraction of these mineral resources. The paper therefore explores the magnitude and essence of public participation in the governance of mineral resources in Zimbabwe. In achieving this, the paper is informed by Arnstein’s ladder of participation as the theoretical framework. In addition, data was gathered from documentary review and in-depth interviews with key informants. The study observed that public participation in respect of mineral governance can be undertaken through public hearing meetings, national budget consultative meetings and alternative mining indabas. However, the current level of participation is within the range of non-participation and lower tokenism. In addition, there is also lack of feedback and information flows in one direction from the Government officials to the citizens. The Government does not really take seriously the contributions from the public. The study therefore proffered some recommendations to enhance the levels of knowledge and participation by the public in the governance of mineral resources in Zimbabwe.
Eclipsing Binary Populations across the Northern Galactic Plane from the KISOGP Survey
Authors: Ren Fangzhou , de Grijs Richard , Zhang Huawei , Deng Licai , Chen Xiaodian , Matsunaga Noriyuki , Liu Chao , Sun Weijia , Maehara Hiroyuki , Ukita Nobuharu , Kobayashi Naoto 
Published: March 2021

Abstract
We present a catalog of eclipsing binaries in the northern Galactic plane from the Kiso Wide-Field Camera Intensive Survey of the Galactic Plane (KISOGP). We visually identified 7055 eclipsing binaries spread across ∼330 deg2, including 4197 W Ursa Majoris/EW-type, 1458 β Lyrae/EB-type, and 1400 Algol/EA-type eclipsing binaries. For all systems, I-band light curves were used to obtain accurate system parameters. We derived the distances and extinction values for the EW-type objects from their period–luminosity relation. We also obtained the structure of the thin disk from the distribution of our sample of eclipsing binary systems, combined with those of high-mass star-forming regions and Cepheid tracers. We found that the thin disk is inhomogeneous in number density as a function of Galactic longitude. Using this new set of distance tracers, we constrain the detailed structure of the thin disk. Finally, we report a global parallax zero-point offset of Δπ = −42.1 ± 1.9 (stat.) ± 12.9 (syst.) μas between our carefully calibrated EW-type eclipsing binary positions and those provided by Gaia Early Data Release 3. Implementation of the officially recommended parallax zero-point correction results in a significantly reduced offset. Additionally, we provide a photometric characterization of our EW-type eclipsing binaries that can be applied to further analyses.
Spitzer IRAC Photometry of JWST Calibration Stars
Authors: Krick Jessica E. , Lowrance Patrick , Carey Sean , Laine Seppo , Grillmair Carl , Van Dyk Schuyler D. , Glaccum William J. , Ingalls James G. , Rieke George , Hora Joseph L. , Fazio Giovanni G. , Gordon Karl D. , Bohlin Ralph C. 
Published: March 2021

Abstract
We present infrared photometry of all 36 potential JWST calibrators for which there is archival Spitzer IRAC data. This photometry can then be used to inform the stellar models necessary to provide absolute calibration for all JWST instruments. We describe in detail the steps necessary to measure IRAC photometry from archive retrieval to photometric corrections. To validate our photometry, we examine the distribution of uncertainties from all detections in all four IRAC channels as well as compare the photometry and its uncertainties to those from models, ALLWISE, and the literature. Seventy-five percent of our detections have standard deviations per star of all observations within each channel of less than 3%. The median standard deviations are 1.2%, 1.3%, 1.1%, and 1.9% in [3.6]–[8.0], respectively. We find less than 8% standard deviations in differences of our photometry with ALLWISE and excellent agreement with literature values (less than 3% difference), lending credence to our measured fluxes. JWST is poised to do groundbreaking science, and accurate calibration and cross-calibration with other missions will be part of the underpinnings of that science.
Swift Follow-up Observations of Gravitational-wave and High-energy Neutrino Coincident Signals
Authors: Keivani Azadeh , Kennea Jamie A. , Evans Phil A. , Tohuvavohu Aaron , Rapisura Riki , Oates Samantha R. , Countryman Stefan , Bartos Imre , Márka Zsuzsa , Veske Doğa , Márka Szabolcs , Fox Derek B. 
Published: March 2021

Abstract
Electromagnetic observations of gravitational-wave and high-energy neutrino events are crucial in understanding the physics of their astrophysical sources. X-ray counterparts are especially useful in studying the physics of the jet, the energy of the outflow, and the particle acceleration mechanisms in the system. Ultraviolet and optical observations can help us constrain the mass and velocity of the outflow and provide hints on the viewing angle. We present the Neil Gehrels Swift Observatory prompt searches for X-ray and UV/optical counterparts to the joint gravitational-wave and high-energy neutrino coincident events that happened during the third observing run of LIGO/Virgo. Swift observed the overlap between gravitational-wave and neutrino error regions for three of the considerable (p-value < 1%) joint gravitational-wave and high-energy neutrino coincident alerts, which were generated by the IceCube Neutrino Observatory in real time after triggering by the LIGO/Virgo gravitational-wave public alerts. The searches did not associate any X-ray or UV/optical counterparts with any of the joint gravitational-wave and high-energy neutrino coincident events; however, the follow-up of these alerts significantly improved the tiling techniques covering regions between the gravitational-wave sky maps and the neutrino’s error regions, making the real-time system ready for future potential discoveries. We discuss the details of each follow-up procedure, the results of each search, and the plans for future searches.
Lithologic Controls on Silicate Weathering Regimes of Temperate Planets
Authors: Hakim Kaustubh , Bower Dan J. , Tian Meng , Deitrick Russell , Auclair-Desrotour Pierre , Kitzmann Daniel , Dorn Caroline , Mezger Klaus , Heng Kevin 
Published: March 2021

Abstract
Weathering of silicate rocks at a planetary surface can draw down CO2 from the atmosphere for eventual burial and long-term storage in the planetary interior. This process is thought to provide essential negative feedback to the carbonate-silicate cycle (carbon cycle) to maintain clement climates on Earth and potentially similar temperate exoplanets. We implement thermodynamics to determine weathering rates as a function of surface lithology (rock type). These rates provide upper limits that allow the maximum rate of weathering in regulating climate to be estimated. This modeling shows that the weathering of mineral assemblages in a given rock, rather than individual minerals, is crucial to determine weathering rates at planetary surfaces. By implementing a fluid-transport-controlled approach, we further mimic chemical kinetics and thermodynamics to determine weathering rates for three types of rocks inspired by the lithologies of Earth's continental and oceanic crust, and its upper mantle. We find that thermodynamic weathering rates of a continental crust-like lithology are about one to two orders of magnitude lower than those of a lithology characteristic of the oceanic crust. We show that when the CO2 partial pressure decreases or surface temperature increases, thermodynamics rather than kinetics exerts a strong control on weathering. The kinetically and thermodynamically limited regimes of weathering depend on lithology, whereas the supply-limited weathering is independent of lithology. Our results imply that the temperature sensitivity of thermodynamically limited silicate weathering may instigate a positive feedback to the carbon cycle, in which the weathering rate decreases as the surface temperature increases.
Midsummer Atmospheric Changes in Saturn’s Northern Hemisphere from the Hubble OPAL Program
Authors: Simon Amy A. , Hueso Ricardo , Sánchez-Lavega Agustín , Wong Michael H. 
Published: March 2021

Abstract
Using the Hubble Space Telescope, Saturn was observed in 2018, 2019, and 2020, just after the northern hemisphere summer solstice. Analysis of multispectral imaging data reveals three years of cloud changes associated with a 70° N storm that began in 2018. Additionally, there is an increase in equatorial brightness and perhaps haze optical depth at 0° to 7° N. There are small midsummer changes at the north pole, with a thin blue feature near the polar hexagon’s outer edge disappearing between 2019 and 2020 and increasingly reddish polar haze. Zonal winds at most latitudes remain close to values obtained by the Cassini mission with a slight increase of winds in the equatorial zone. Yearly cloud changes, while noticeable, are small compared with the changes observed between the Voyager (northern spring) and Cassini (southern summer to northern spring) eras, but further observations will provide a longer baseline for comparison.