bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ocular inflammatory events following COVID-19 vaccination: a multinational case series
Authors: Testi Ilaria , Brandão-de-Resende Camilo , Agrawal Rupesh , Pavesio Carlos 
Published: November 2021

Abstract
Background
Inflammatory adverse events following COVID-19 vaccination are being reported amidst the growing concerns regarding vaccine’s immunogenicity and safety, especially in patients with pre-existing inflammatory conditions.
Methods
Multinational case series of patients diagnosed with an ocular inflammatory event within 14 days following COVID-19 vaccination collected from 40 centres over a 3 month period in 2021.
Results
Seventy patients presented with ocular inflammatory events within 14 days following COVID-19 vaccination. The mean age was 51 years (range, 19-84 years). The most common events were anterior uveitis (n = 41, 58.6%), followed by posterior uveitis (n = 9, 12.9%) and scleritis (n = 7, 10.0%). The mean time to event was 5 days and 6 days (range, 1-14 days) after the first and second dose of vaccine, respectively. Among all patients, 36 (54.1%) had a previous history of ocular inflammatory event. Most patients (n = 48, 68.6%) were managed with topical corticosteroids. Final vision was not affected in 65 (92.9%), whereas 2 (2.9%) and 3 (4.3%) had reduction in visual acuity reduced by ≤ 3 lines and > 3 lines, respectively. Reported complications included nummular corneal lesions (n = 1, 1.4%), cystoid macular oedema (n = 2, 2.9%) and macular scarring (n = 2, 2.9%).
Conclusion
Ocular inflammatory events may occur after COVID-19 vaccination. The findings are based on a temporal association that does not prove causality. Even in the possibility of a causal association, most of the events were mild and had a good visual outcome.
Head-to-head analysis of immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19-priming and BNT162b2 or mRNA-1273-boosting with homologous COVID-19 vaccine regimens
Authors: Sester Martina , Klemis Verena , Schmidt Tina , Schub David , Mihm Janine , Marx Stefanie , Abu-Omar Amina , Ziegler Laura , Hielscher Franziska , Guckelmus Candida , Urschel Rebecca , Wagenpfeil Stefan , Schneitler Sophie , Becker Soeren , Gärtner Barbara , Sester Urban 
Published: November 2021

Abstract
Head-to-head analyses of immunogenicity and reactogenicity between the authorized homologous vaccine-regimens and heterologous combinations thereof are currently limited. Using a convenience cohort of 331 healthy individuals, we show that humoral and cellular immunity after vaccination with ChAdOx1-nCoV-19 followed by either BNT162b2 (n=66) or mRNA-1273 (n=101) is equivalent or superior to homologous mRNA-regimens (n=43 BNT162b2, n=59 mRNA-1273), and more pronounced than after homologous ChAdOx1-nCoV-19 vaccination (n=62). Levels of spike-specific CD8 T cells were highest in both heterologous regimens, and significantly higher than all three homologous combinations. Among mRNA-containing combinations, spike-specific CD4 T-cell levels in regimens including mRNA-1273 were higher than respective combinations with BNT162b2. Polyfunctional T-cell levels were highest in regimens based on ChAdOx1-nCoV-19-priming. All five regimens were well tolerated with most pronounced reactogenicity upon ChAdOx1-nCoV-19-priming and mRNA-1273-boosting. In conclusion, immunogenicity after heterologous vector/mRNA-boosting and homologous mRNA-regimens is superior to homologous vector-regimens with notable differences between mRNA vaccines.
Analysis of Atmospheric Circulation Patterns in the Babol Roud Watershed
Authors: Razmi Robab , Hesami Narges , Rabiee Zahra , Ghane Mohsen 
Published: November 2021

Abstract
precipitation is a variable whose value, intensity, and type changes in temporal and spatial dimensions. the occurrence of heavy rainfall is an aspect of these changes which is a dangerous factor in the incidence of natural disasters such as flooding. In this study, with the aim of investigating the behavior of precipitation and discharge of Babol Roud watershed, the Talar station was selected as an indicator station. Then, the cycles governing precipitation and discharge parameters of the station were estimated at the annual scale (1976 - 2011) based on the spectral analysis technique. The results of spectral analysis on time series of discharge and precipitation at a 95% certainty level indicate the existence of a common annual 2 cycle in discharge and annual precipitation. The coincidence of a 2 years old significant cycle in the time series of precipitation and discharge means that in 2 years the repetition of annual precipitation events affects annual discharge. The Extraction heavy rainfall in the Babol Roud watershed was examined the study of atmospheric conduct at the sea level pressure (SLP) and the elevation of the atmosphere medium level (500 hpa level) at the time of their occurrence. After grouping these days, based on cluster analysis technique, three patterns were determined as the dominant patterns of heavy rainfall in the Babol Roud Watershed.
Negotiating Climate and Energy Futures: Prospects for Climate Compatible Recoveries in Latin America and the Caribbean
Authors: Hampl Nora 
Published: November 2021

Abstract
Funding agencies will play an important role in energy transitions in post-COVID recoveries in Latin America and the Caribbean (LAC). If “done right,” they can contribute to climate compatible growth (CCG) aligned with the Paris Agreement and the 2030 Agenda, and also achieve the target of universal access. In this study, a comprehensive document analysis was conducted to analyse how funding institutions can help overcome pre-existing gaps and vulnerabilities, and simultaneously promote equitable energy transitions and decarbonization pathways in the region.The research findings implicate policy-making in the following ways: first, all-of-energy matrix in planning needs to be taken into account, if the projected recoveries are to be transformative and climate compatible. Second, enforceable legal and institutional frameworks that link climate and renewable energy law, with contingencies for rural and urban planning, would make it possible for local actors to take immediate action. Third, equal local access to capabilities and training can support synergies between the latest climate science, the implementation of low-carbon solutions, and cross-sectoral innovation. As a recommendation, the study proposes establishing Research & Training Centres (RTCs) at sub-national levels as an interface between climate-energy research community (local and international), climate and energy practitioners, and local communities.
The influence of accessory rods and connectors on the dynamic response of spine fixation
Authors: Pekedis Mahmut , Altan Murat , Akgul Turgut , Yildiz Hasan 
Published: November 2021

Abstract

Purpose This study presents a nondestructive technique to assess the influence of accessory rods and connectors on the dynamic response of spine fixation.Methods Eighteen spine specimens were divided into three construct groups such as group I (2 rods [2R]), II (2 primary rods + 2 accessory rods with 2 transverse connectors [4R+2TC]) and III (2 primary rods + 2 accessory rods with 4 transverse connectors [4R+4TC]). Anterior corpectomy was performed for all specimens. A custom test setup was built to assess the dynamic responses of constructs in flexion-extension (FE) and left-right lateral bending (LRLB) motions. This setup can slide in lateral direction, and it is excited with an electrodynamic shaker vibrated at band limited random frequencies. Accelerometer and reusable dynamic strain sensors were installed on constructs to monitor the dynamic responses. Quasi-static eccentric loading tests were performed to determine the range of motion (RoM).Results The results demonstrated that accessory rods significantly increase the resonance frequency (RF) and decrease the strain over standard 2R construction. Although 4R+4TC provided greatest reduction in rod strain over 4R+2TC and 2R, additional 2 connectors have no significant influence on dynamic response in FE motion.Conclusions An increase in the number of rods has a significant role on the improvement of the fixation's integrity in FE and LRLB motions. However, the additional transverse connectors have significant involvements only in LRLB motion. RF obtained from dynamic tests correlated with the RoM which indicates that the technique could be used as an addendum to the quasi-static test.
INPP5F Translocates Into Cytoplasm And Interacts With ASPH To Promote Tumor Growth in Hepatocellular Carcinoma
Authors: Zhou Qianlei , Lin Jianhong , Yan Yongcong , Meng Shiyu , Liao Hao , Chen Ruibin , He Gui , Zhu Yue , He Chuanchao , Mao Kai , Wang Jie , Zhang Jianlong , Zhou Zhenyu , Xiao Zhiyu 
Published: November 2021

Abstract
Background: Increasing evidence has suggested inositol polyphosphate 5-phosphatase family contributes to tumorigenesis and tumor progression. However, the role of INPP5F in hepatocellular carcinoma (HCC) and its underlying mechanisms is unclear.Methods: The expression of INPP5F in HCC was analyzed in public databases and our clinical specimens. The biological functions of INPP5F were investigated in vitro and vivo. The molecular mechanism of INPP5F in regulating tumor growth were studied by transcriptome-sequencing analysis, mass spectrometry analysis, immunoprecipitation assay and immunofluorescence assay.Results: High expression of INPP5F was found in HCC tissues and was associated with poor prognosis in HCC patients. Overexpression of INPP5F promoted HCC cell proliferation, and vice versa. Knockdown of INPP5F suppressed tumor growth in vivo. Results from transcriptome-sequencing analysis showed INPP5F not only regulated a series of cell cycle related genes expression (c-MYC and cyclin E1), but also promoted many aerobic glycolysis related genes expression. Further studies confirmed that INPP5F could enhance lactate production and glucose consumption in HCC cell. Mechanistically, INPP5F activated Notch signaling pathway and upregulated c-MYC and cyclin E1 in HCC via interacting with ASPH. Interestingly, INPP5F was commonly nuclear-located in cells of adjacent non-tumor tissues, while in HCC, cytoplasm-located was more common. LMB (nuclear export inhibitor) treatment restricted INPP5F in nucleus and was associated with inhibition of Notch signaling and cell proliferation. Sequence of nuclear localization signals (NLSs) and nuclear export signals (NESs) in INPP5F aminoacidic sequence were then identified. Alteration of the NLSs or NESs influenced the localization of INPP5F and the expression of its downstream molecules. Furthermore, we found INPP5F interacted with both exportin and importin through NESs and NLSs, respectively, but the interaction with exportin was stronger, leading to cytoplasmic localization of INPP5F in HCC. Conclusion: These findings indicate that INPP5F functions as an oncogene in HCC via a translocation mechanism and activating ASPH-mediated Notch signaling pathway. INPP5F may serve as a potential therapeutic target for HCC patients.
Availability of Safe Second-Trimester Abortion Services in Health Facilities in Accra, Ghana
Authors: Gbagbo Fred Yao , Morhe Renee Aku Sitsofe , Morhe Emmanuel Komla Senanu 
Published: November 2021

Abstract
Background

Despite a liberal abortion law, access to safe second trimester abortion services in Ghana are challenging for many women. This study sought to examine providers, methods employed, cost, and other determinants of availability of second-trimester abortion services in health facilities in Accra, Ghana in 2019 to inform policy and program decisions.
Methods

A two-stage mixed quantitative and qualitative study designs were employed in the conduct of this study. The first stage was a short interaction of the mystery client with a clinical care provider to identify health facilities that provide second trimester induced abortion, the cost, and referral practices, where the facility did not have the service. The second stage was in-depth interviews of second-trimester abortion care providers and non-providers in various health facilities. For internal validity, it also explored the procedure cost, referral, and other practices at the health facilities included in the study, independent of what was captured in the mystery client survey.
Results

Second-trimester abortion services in Accra, Ghana are widely unavailable even in most facilities that provided abortion services. Referral policies and practices indicated by the service providers at various facility levels were inadequate. Criminalization of the procedure, social stigma, and fear of complications are the main factors that adversely influence the availability of second-trimester abortion in health facilities in Accra.
Conclusions

Albeit increasing demand for second-trimester abortion in health facilities in Accra, services are not readily available due to the ambiguity of the law, its interpretation, and limited flow of accurate information on providers. Policies and programs that limit access to Second-trimester abortions in Ghana are amendable to ensure safe services.
Linking Activity of Common Pipistrelles, Pipistrellus Pipistrellus, in an Urbanised Area With a Nearby Mass Swarming Site
Authors: Nusová Gréta , Uhrin Marcel , Kaňuch Peter 
Published: November 2021

Abstract
The Erňa cave, a mass winter hibernaculum and important swarming site of the common pipistrelle, Pipistrellus pipistrellus, is located in the Slovak Karst, near the Košice urban agglomeration in eastern Slovakia. Over the past two decades, the unusual behaviour of late summer or autumn accidental but abundant occurrences of this species have been observed in buildings (so-called invasions) in Košice. It has been hypothesised that these events are related to bats swarming and hibernating in the Erňa cave; however, causality has not been confirmed. We measured the relative activity of bats from the end of the breeding season through the invasions and autumn swarming prior to the onset of hibernation by recording their echolocation calls on car-based transects in order to find any spatial and temporal linkage between activity in the urban area and the swarming site. Over two years we recorded 6,253 sequences with echolocation calls of P. pipistrellus and 5,239 records of other bats along four transects totalling 7,121 km in length. Spatial pattern analysis found that the city agglomeration presented a local hotspot of the species’ activity, especially during the invasion season. Multivariate generalised additive modelling confirmed an increased density of records of P. pipistrellus between the urban area and the hibernaculum in the pre-hibernation season, whereas this pattern was not found to be consistent on the control transects near the city. Contrary to that, other bat species showed little variation in their activity between transects and seasons. The obtained results suggest that the relatively short geographical distance between the urban agglomeration and the large swarming site is likely a clue to the frequent city invasions of the species, although the role of the city as a hibernation area cannot be completely omitted.
Numerical Study of Desiccation Cracking In Clayey Soil: A New FEM-MPM Coupling Method.
Authors: Jihen Feki , Salma Souissi , Houcem Trabelsi , Hassen Sabeur 
Published: November 2021

Abstract
Desiccation cracking is a critical phenomenon soliciting the soil hydro-mechanical behavior, and significantly affects the performance of soil in geotechnical engineering. For this reason, an increasing interest toward studying and simulating the soil crack propagation, after a severe exposure to dry conditions (induced by desiccation), has been noticed during the recent years. However, major gaps remain in the previously developed models to properly provide a realistic prediction of the cracks pattern scheme especially when using the classical Finite Element Method (FEM), widely used in the geotechnical application. In this study, owing to the limitation of this method in re-meshing and dealing with large deformation, the authors were prompted to couple FEM with a mesh-free method: The Material Point Method (MPM) to overcome the individual drawbacks of each method. The dominant influencing factors on soil desiccation cracking have been assessed through a desiccation test performed in climatic chamber and using a digital image processing technique (image analysis) for a quantitative description of the studied sample. A model that relates porosity with suction and tensile strength was used to study the effect of the shrinkage phenomena in desiccation term, and to simulate the crack propagation in a thin clayey soil layer using the Code_Bright software. Consequently, a clear and connected crack pattern was observed, the problem of mesh dependency was clearly overcome proving the validity of the approach and providing a further insight into the behavior of clayey soil exposed to desiccation factors.
Antioxidant Potential of Pediococcus Pentosaceus Strains from the Sow Milk Bacterial Collection in Weaned Piglets
Authors: Wang Leli , Liu Qihang , Chen Yuwei , Zheng Xinlei , Wang Chuni , Qi Yining , Dong Yachao , Xiao Yue , Chen Cang , Chen Taohong , Huang Qiuyun , Huang Jialu , Zhai Zongzhao , Long Cimin , Yang Huansheng , Li Jianzhong , Wang Lei , Zhang Gaihua , Liao Peng , Liu Yongxin , Huang Peng , Wang Qiye , Chu Huanhuan , Yin Jia , Yin Yulong 
Published: November 2021

Abstract
Background: In modern animal husbandry, breeders pay increasing attention to improving sow nutrition during pregnancy and lactation to favor the health of neonates. Sow milk is a main food for piglets during their first three weeks of life, which is not only a rich repository of essential nutrients and a broad range of bioactive compounds, but also an indispensable source of commensal bacteria. Maternal milk microorganisms are important sources of commensal bacteria for neonatal gut. Bacteria from maternal milk may serve as an additive to confer a health benefit on the composition of the indigenous microbiota of piglets. Methods: The sow milk microbiota was collected using the culturomics methods of Continuous Culture and Interval Sampling, following by the identification of 16S rDNA gene sequences. To screen potential probiotics, the functional evaluation was conducted to assess their antagonistic activity against pathogens in vitro and evaluate their resistance against oxidative stress in damaged Drosophila induced by paraquat. In piglet feeding trial, a total of 54 newborn suckling piglets were chosen from nine sows and randomly assigned to three treatments with different concentration of a candidate strain. Multiple approaches were carried out to verify its antioxidant function including western blotting, enzyme activity analysis, metabolomics and 16S rDNA sequencing. Results: The 1240 isolates were screened out from the sow milk microbiota and grouped into 271 bacterial taxa based on a nonredundant set of 16S rDNA gene sequences. Among 80 Pediococcus isolates, a new Pediococcus pentosaceus strain (SMM914) showed best performance in inhibition ability against swine pathogens and in Drosophila model challenged by paraquat. Pretreatment of piglets with SMM914 induces the Nrf2-Keap1 antioxidant signaling pathway and greatly affected the pathways of amino acid metabolism and lipid metabolism in plasma. In colon, Lactobacillus was significantly increased in the high dose of SMM914 group compared with the control group. Conclusion: SMM914 functions as a promising probiotic conferring antioxidant capacity by activating the Nrf2-Keap1 antioxidant signaling pathway in piglets. Our study provided useful resources for deeply understanding the relationships between the maternal microbiota and offspring.
Genetic Diversity And Population Structure of Indian Mustard (Brassica Juncea) Based On Morphological and Molecular Markers
Authors: Yadav Prashant , Yadav Sushma , Mishra Anurag , Chaudhary Rajat , Kumar Arun , Meena Hari Singh , Rai Pramod Kumar 
Published: November 2021

Abstract
Rapeseed-mustard is one of the most important oilseed crops and providing a major source of edible oil in the world besides having other economic importance like leafy vegetables, ornamentals, and hedge crops. However, the genetic diversity present in the Brassica gene pool has not been investigated in detail. To address this problem, a study was conducted on 76 genotypes of B. juncea including cultivars, exotic lines, registered genetic stocks, advanced breeding lines, and germplasm lines. The genetic diversity was analyzed with the help of 50 polymorphic SSR and EST-SSR markers. For these genotype-marker combinations, a total of 126 alleles were amplified. Using molecular and phenotypic data, the dendrogram was constructed based on Jaccard’s similarity coefficient and Manhattan dissimilarity coefficient and linkage algorithm UPGMA. All the genotypes were grouped into 5 clusters based on their dissimilarity matrix. Population structure analysis grouped the genotypes in 8 clusters and various degrees of admixture was also observed. The grouping of genotypes appears effective as per their pedigree. The marker data was found more accurate to characterize the diversity and study the population structure than the quantitative trait data. The results of the present investigation will provide useful information for the identification of important alleles for future studies and pave the way to enhance genetic gains in Indian mustard.
Psychological Characteristics of Lung Cancer Patients During the 2019 Novel Coronavirus Outbreak: A Cross-Sectional and Longitudinal Study Based on a Propensity Score-Matched Population
Authors: Qian Kai , Deng Yi , Chen Yun , Peng Hao , Jiang Li-Hong 
Published: November 2021

Abstract
Objective: This study sought to reveale the psychological characteristics of lung cancer patients at different time points of the COVID-19 epidemic. Methods: This cross-sectional study used data from two different regional medical centers. 128 pairs of lung cancer (LC) patients and non-lung cancer subjects (NLC) were selected through propensity score matching (PSM) analysis. For the longitudinal study, the anxiety and distress state before and during the COVID-19 pandemic were surveyed through a dedicated questionnaire. Results: A total of 135 LC patients and 165 healthy individuals were included in this cross-sectional study. After PSM analysis, 128 pairs of LC patients and NLC were matched and compared in this analysis. During the uptrend period of COVID-19 epidemic, there were significant differences in anxiety between LC patients and NLC (P=0.005). For LC patients, the proportions of severe distress differed significantly between the uptrend and the decline period (22.05% vs 11.90%, P=0.032). In two-way repeated ANOVA analysis, no significant main effect for group or group × condition interaction effect has been founded. The distress of LC patients is mainly manifested as worry. Logistic regression showed that gender (OR=41.48, 95% CI: 9.74-17.97), age (OR=0.20, 95% CI: 0.08-0.50), and education level (OR=4.82, 95% CI: 1.98-11.69) were correlated with “worry” and contributed significantly to the model. Conclusions: This study revealed that lung cancer patients had significant anxiety and distress during the uptrend period of the COVID-19 epidemic. The distress states of LC patients mainly manifested as worry, which was associated with age, gender, and education level.