bluuebunny/crossref_metadata_2025_split huggingface dataset:
Childhood Leukemia and Non-hodgkin Lymphoma Survivors Lack of Knowledge About Their Past Disease and Possible Late Effects. I-BFM ELTEC Study With Chilean and Croatian Participation.
Authors: Becker Ana , Paris Claudia , Roganovic Jelena , Bustos Cristina , Rosas Amaia , Contreras Paula , Zepeda-Ortega Ana J. , Bardi Edit 
Published: October 2021

Abstract
PurposeLate effects in childhood cancer survivors are a major cause of morbidity and mortality. The objective was to establish knowledge about the disease, late effects, self-care practices, application of health knowledge/education, sources of information, and biopsychosocial impact of cancer, and compare the results of Chile and Croatia. Methodsone hundred and seventy-one, five-year survivors who were treated for leukemia or non-Hodgkins lymphoma responded to a questionnaire (119 in Chile and 52 in Croatia). The questionnaire was reviewed by BFM- ELTEC. Resultshealth knowledge about past diagnosis and general treatment had 96% Chilean and 85% Croatian survivors. Ninety percent of Chilean and 73% of Croatian survivors were unaware of possible late effects, and half did not know which specialist to visit for follow-up. Forty-six percent of Chilean and 35% of Croatian survivors knew about healthy lifestyles, but most did not practice them. The 74% of Chileans and 87% of Croatian survivors recalled having received health education during treatment. About 50% survivors in both groups was afraid or anguish, but it was also a growth experience for 60% of Chilean and 42% Croatian survivors. Eighty-seven percent Chilean and 77% Croatian survivors considered themselves physically independent, while 76% and 75% felt psychologically independent, respectively. ConclusionIt was detected a significant lack of knowledge about the specific treatment, late effects, and future health in both countries. They did not achieve significant learning with the education received. Psychological sequelae were found that are important to prevent.
Prioritization of Invasive Alien Species With Potential to Threaten Agriculture And Biodiversity in Kenya Through Horizon Scanning
Authors: Mulema Joseph Mary Kusasira , Day Roger , Nunda Winnie , Akutse Komivi Akutse , Bruce Anani Y. , Gachamba Sospeter , Haukeland Solveig , Kahuthia-Gathu Ruth , Kibet Staline , Koech Asenath , Kosiom Thomas , Miano Douglas Watuku , Momanyi George , Murungi Lucy Kananu , Muthomi James Wanjohi , Mwangi Julianna , Mwangi Maina , Mwendo Nicholas , Nderitu John Huria , Nyasani Johnson , Otipa Miriam , Wambugu Sarah , Were Eric , Makale Fernadis , Doughty Laura , Edgington Steve , Rwomushana Ivan , Kenis Marc 
Published: October 2021

Abstract
Invasive alien species (IAS) rank among the most significant drivers of species extinction and ecosystem degradation, causing significant impacts on ecosystem services, human well-being and socio-economic development. Recent invasions have spread rapidly in Africa due to porous borders constraining maintenance of border biosecurity. Countries also lack adequate information about potential invasions and have limited capacity to reduce risk of invasions. Horizon scanning prioritises the risks of potential IAS through rapid assessments of likelihood of their entry and establishment and their potential socio-economic and environmental impacts. This approach was used to identify and assess risks of 120 potential IAS (70 arthropods, 41 pathogens and 9 nematodes) to Kenya. The likely pathway of arrival for assessed species was mainly as contaminants of commodities, but some could most likely enter as stowaways. All species were scored for likelihood of entry, likelihood of establishment, potential socio-economic impact, and potential environmental impact on a 5-point scale. These individual scores were combined to rank the species according to their overall potential risk for the country. Confidence in individual and overall scores was recorded on a 3-point scale. For the highest-risk species, options for risk mitigation were suggested, including full pest risk analysis, surveillance for early detection, specific surveys for species not officially recorded but whose presence is suspected, and contingency planning. By prioritising risks, this approach can guide resource allocations to interventions that are most likely to reduce risk. It is appropriate for use by National Plant Protection Organisations and other relevant stakeholders in sub-Saharan Africa.
A Property Perceived Service Quality Evaluation Method for Public Building Based on Multi-Source Heterogeneous Information Fusion
Authors: zuo wenjin , Liu Lijun , He Xiaogang , Zhang Xingxian , Zeng Shouzhen 
Published: October 2021

Abstract
The basic information of property perceived service quality (PPSQ) evaluation for public building has the characteristics of multi-source heterogeneity, which challenges the traditional perceived service quality evaluation methods. Based on the classical linear programming technique for multidimensional analysis of preference (LINMAP), a multi-objective LINMAP model is constructed and a new PPSQ evaluation method is proposed to solve such problems. Constructing the multi-objective LINMAP model is the core of constructing the new PPSQ evaluation method. The construction idea of the multi-objective LINMAP model is as follows: First, the multi-source heterogeneous evaluation information is normalized based on the TOPSIS idea. Then, the LINMAP model is extended by using the objective function which is constructed with the minimum variance between the multi-source evaluation information. Finally, the source weight and index weight are determined by the above model, the comprehensive distance of each property service project is calculated, and the best choice of property service project is found. The case study verifies the feasibility and effectiveness of the multi-objective LINMAP model, but also reflects the new requirement of comprehensively and objectively evaluates PPSQ for public building.
Basal metabolic rate and risk of multiple sclerosis: a Mendelian randomization study
Authors: liu chunxin , qiu wei , lu yaxin , chen jingjing , zhan yiqiang , Liu zifeng 
Published: October 2021

Abstract
Objective

To determine the relationship between basal metabolic rate (BMR) and multiple sclerosis (MS) susceptibility, we used genome-wide association study (GWAS) summary statistics data from the International Multiple Sclerosis Genetics Consortium on a total of 115,803 participants of European descent, including 47,429 MS patients and 68,374 controls.
Methods

We selected 378 independent genetic variants strongly associated with BMR in a GWAS involving 454,874 participants as instrumental variables to examine a potential causal relationship between BMR and MS.
Results

A genetically predicted higher BMR was associated with a greater risk of MS (odds ratio [OR]: 1.283 per one standard deviation increase in BMR, 95% confidence interval [CI]: 1.108–1.486, P = 0.001). Moreover, we used the lasso method to eliminate heterogeneity (Q statistic = 384.58, P = 0.370). There was no pleiotropy in our study and no bias was found in the sensitivity analysis using the leave-one-out test.
Conclusions

We provide novel evidence that a higher BMR is an independent causal risk factor in the development of MS. Further work is warranted to elucidate the potential mechanisms.
Combination of Single-Molecule Long-Read Sequencing and Illumina Sequencing Revealed the Mechanism of Anthocyanins Accumulation in an Ornamental Grass, Pennisetum Setaceum ‘Rubrum’
Authors: Liu Lingyun , Teng Ke , Fan Xifeng , Zhang Hui , Han Chao , Wu Juying , Chang Zhihui 
Published: October 2021

Abstract
Pennisetum setaceum ‘Rubrum’ is an ornamental herb with purple leaves, and it is widely used in the construction of landscaping. However, the current next generation sequencing (NGS) transcriptome information is not satisfactory mainly because of the enormous difficulty in obtaining full-length transcripts. What’s more, the molecular mechanisms of anthocyanin accumulation have not been thoroughly studied. In this study, we used PacBio full-length transcriptome sequencing combined with NGS sequencing technology to conduct transcriptome analysis on leaves showing different colors at different stages to clarify the molecular mechanism involved in the color change of P. setaceum ‘Rubrum’. A total of 280,413 full-length non-chimeric reads (FLNC) sequences were obtained based on single-molecule long-read sequencing technology. We obtained 140,633 high quality (HQ) transcripts and 2,683 low quality (LQ) transcripts and identified 5,352 alternative splicing (AS). In addition, a total of 93,066 ORFs, including 57,457 full open links and 2,910 lncRNA sequences were screened out. Furthermore, a total of 10,795 differentially expressed genes were identified. Gene ontology (GO) cluster and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed the underlying mechanism of anthocyanin accumulation. In this study, to our best knowledge, we provided the full-length transcriptome information of P. setaceum ‘Rubrum’ for the first time. The underlying mechanism of anthocyanin accumulation in P. setaceum ‘Rubrum’ was further discussed based on the newly generated transcriptome data. The information will not only facilitate the gene function studies but also pave the way for future breeding projects of Pennisetum setaceum .
Analysis of urban horizontal expansion and its impact on the surrounding land using GIS and remote sensing: a case of Werabe town
Authors: Mamuye Fikadu , Ebabu Dinku 
Published: October 2021

Abstract
Nowadays, urbanization becomes the widest spreading and expanding event in the world. The issue of urbanization is one of the most important threats for developing countries like Ethiopia. Werabe town, which is found in southern and central parts of the country specifically in the Silte zone south nation nationality people (SNNP) region, is one of the rapidly growing towns at the moment. Therefore, this research is intended to assess the horizontal expansion of the urban and its impact on the use of the surrounding land in Werabe town using a Geographic Information System and integrating socio-economic data. To do this, a Land sat 8 satellite image was used to generate the change detection analysis and all the relevant primary data were gathered. After all, supervised image classification algorithms were applied to determine the available land use types by integrating socio-economic information. Finally, accuracy assessments were done to crosscheck whether the features are accurately classified in the Arc GIS. Based on this, in Werabe town built-up land was increased from 1963.98 ha (12.5%) in 2009 to 5251, 95 (33.4%) in 2019. Hence, in the study period built-up area was increased by 3287.97ha (20.9%). The forest cover of the study area in 2009 was 3798.27 ha (24.2%), however, it was decreased to 1358.01ha (8.6%) in the year 2019. Thus 2440.17 ha (15.6%) forest cover was deforested. For agricultural activity, 8833.41 ha (56.2%) of land was used in the year 2009 but it was altered to 7198.83 ha (45.7%) in the year 2019. Hence from 2009-2019, agricultural land was decreased by 1634.58 ha (10.5%). Bare land cover in 2009 was 1130.85 ha (7.2%) but it increased by 786.87 (5%) and became 1917.72 ha (12.2%) in the 2019 year. The study evidences that, urban built-up activity is expanding to all the surrounding landmasses, especially it is invading agriculture and forest cover lands of the peri-urban areas. Therefore, to prevent the loss of fertile lands against the ongoing expansion of urban areas, the integration of remote sensing and GIS with appropriate urban land management policy is vital.
Allergic inflammatory responses induced by traffic-related PM2.5 in BALB/c mice
Authors: Wei Hai Ying , Yu Huan , Zhang Lifeng , Dong Zhenyu 
Published: October 2021

Abstract
Previous studies have shown that PM2.5 is associated with airway inflammation and lung injury. However, the association between traffic-related PM2.5 (TR-PM) exposure and OVA-induced allergic inflammation is not fully elucidated. In this study, we assessed allergic inflammatory responses of mice induced by TR-PM. PM2.5 was collected from a roadside with heavy traffic, and its soluble extract was prepared. Mice were treated with OVA, TR-PM alone, and OVA + TR-PM. The inflammatory cells were counted, and inflammation-related cytokines IL-4, IL-17A, and IL-10 in bronchoalveolar lavage fluid (BALF) were determined by the radioimmunity assay. Allergy-induced inflammation and lung injury were investigated by histopathological analyses. The expression of IL-4, IL-17A, and IL-10 mRNA was analyzed by RT-PCR. Our results revealed that TR-PM exposure, combined with OVA allergen sensitization, increased the inflammatory cells in BALF as well as levels of IgE in lung tissue; increased the IL-4 and IL-17A levels in BALF significantly, but decreased IL-10 level. The histopathologic results demonstrated that TR-PM markedly exacerbated the OVA-induced neutrophilic granulocyte, lymphocyte, and macrophage infiltration. Furthermore, the expression of IL-4, IL-17A and IL-10 mRNA was well in agreement with the results of the inflammatory cytokines. In conclusion, during the sensitization to allergic antigens, TR-PM exposure triggers severe allergic inflammation and lung injury. These findings suggest that commuters should use public transportation instead of riding motorcycles or walking during rush hours.
Endocrine-metabolic Adaptations in Dorper Ewes: Comparison Between Single and Twin Pregnancies During Gestation, Delivery, and Postpartum
Authors: Santarosa Bianca Paola , Ferreira Danilo Otávio Laurenti , Hooper Henrique Barbosa , Sinzato Yuri Karen , Damasceno Débora Cristina , Polizel Daniel Montanher , Fioratti Eduardo Gorzoni , Santos Vítor Hugo dos , Silva Andreza Amaral da , Gonçalves Roberto Calderon 
Published: October 2021

Abstract
The present study involved a blood glucose, hormonal profile, and insulin resistance evaluation in sheep from conception until 48 h postpartum. A total of 60 healthy Dorper ewes, raised under semi-intensive management were included in the study. Two experimental groups were applied: G1, single pregnancy (n = 30) and G2, twin pregnancy (n = 30). The experimental time points were immediately after fixed-time artificial insemination; at 30 d, 90 d, 120 d, 130 d, and 140 d of pregnancy; on the delivery day (DD); and at 24 h (PD1) and 48 h (PD2) postpartum. Blood samples were taken to analyse glucose, insulin, glucagon, cortisol, thyroid hormones (T3 and T4) levels. All parameters showed significant differences over the analysed sample times; however, only cortisol showed differences within groups, with the G1 having higher values than the G2 group. The interaction of the groups in the nine sample times showed a significant result (P = 0.001) only for glucagon. The number of foetuses directly interfered with the glucagon profile throughout gestation and insulin concentration postpartum. The glucose, cortisol, insulin, glucagon, and HOMA IR concentrations increased at DD and decreased at PD1 and PD2. T3 and T4 levels increased at DD. Despite the changes found in the endocrine system and metabolism in Dorper ewes throughout pregnancy, the nutritional management ensured a healthy status during pregnancy, delivery, and postpartum.
Effects of Risperidone on Serum Testosterone and Metabolic Parameters Among Schizophrenic Patients in Khartoum State, Sudan.
Authors: Mousa Husham Ali Abdalla , Ali Mazin Mohamed Abdalgadir , Omer Mohammed Eltahier Abdalla , Elmahi Osman Kamal Osman , Hamadelneel Gad Allah 
Published: October 2021

Abstract
Background: Antipsychotics (AP) are commonly and increasingly prescribed to children and adolescents effectively for the treatment of schizophrenia symptoms, but they are often associated with different side effects, many studies report a decrease in testosterone and gonadotropins due to an AP-induced hyperprolactinemic effect in men, it has been found that lower levels of testosterone is correlated with negative symptoms in patients with schizophrenia.Aim: Study was aimed to determine the effect of Risperdone on testosterone level in patients with Schizophrenia in Khartoum State.Materials and Methods: A cross sectional hospital based study recruited 100 patients diagnosed with Schizophrenia, attended at Military Hospital, Khartoum state, during January to March 2021. The plasma testosterone was estimated using ichromaTM semi automated analyzer, the collected data were analyzed using SPSS version (25).Results: A cross sectional study recruited 100 patients, diagnosed with Schizophrenia, attended Military Hospital during January 2021, their age range from 25 to 52 years old (mean±SD = 38.1±6.42), to estimate testosterone levels in their plasma beside determine BMI and signs and symptoms related to Schizophrenia. The study found that mean of testosterone level was 3.44±2.11, mean of glucose level was 146.4±22.57 SD while mean of uric acid was 6.51±0.85 with strong significant statistical differences P. value = 0.001, 0.001 and 0.002 respectively, reverse correlation was observed between testosterone and body mass index, age, duration of the disease, glucose and uric acid levels (R= -0.33, -0.32, -0.37, -0.22 and -0.20 respectively).Conclusion: Risperidone drug used in treatment patients with Schizophrenia was lowering the level of testosterone hormone. And also there was association between testosterone with blood glucose, uric acid, age and duration of disease.
High incidence and regional distribution of cleft palate in Finns are associated with a functional variant in an IRF6 enhancer
Authors: Rahimov Fedik , Nieminen Pekka , Kumari Priyanka , Juuri Emma , Nikopensius Tiit , Karjalainen Juha , Kurki Mitja , Palotie Aarno , NA FinnGen , Heliövaara Arja , Paraiso Kitt , Visel Axel , Fakhouri Walid , Schutte Brian , Cornell Robert , Rice David 
Published: October 2021

Abstract
In Finland the frequency of isolated cleft palate (CP) is higher than that of isolated cleft lip (CL) or cleft lip with cleft palate (CLP). This trend contrasts to that in other countries but its genetic underpinnings are unknown. We performed a genome-wide association study for orofacial cleft, which includes CL, CLP, and CP in the Finnish population. We identified rs570516915, a single nucleotide polymorphism that is virtually specific to Finns and Estonians, as being strongly associated with orofacial cleft, and predominantly with CP (p = 5.25 x 10-34, OR = 8.65, 95% CI 6.11-12.25). The risk allele frequency for rs570516915 parallels the regional variation of CP prevalence in Finland, and the association was replicated in an independent sample of CP cases from Estonia (p < 1.3 x 10-11). The rs570516915 variant lies in an IRF6 (Interferon Regulatory Factor 6) enhancer active in ectodermal and oral epithelial cells. Other variants in the IRF6 locus, including those in the same enhancer, are associated with orofacial cleft, but predominantly with CL or CLP, suggesting shared mechanisms in the distinct processes of lip and palate development. By luciferase and transgenic mouse reporter assays we found that the risk allele of rs570516915 diminishes the activity of the enhancer. CRISPR-Cas9 edited oral epithelial cells demonstrate that rs570516915 disrupts an IRF6 binding site and decreases the expression of IRF6, suggesting impaired IRF6 autoregulation as the molecular mechanism underlying risk for CP.
Alcohol-Induced Mitochondrial and NADPH Oxidase Mediated ROS Generation Alter Neuroendocrine Status: Role of Pterocarpus Santalinus
Authors: Bulle Saradamma , Pulakuntla Swetha , Pannuru Padmavathi , Aramgam Sreelatha , Bagewadi Zabin , Badri Kameswara Rao , Mulla Sikandar , NCh Varadacharyulu , Vaddi Damodara Reddy 
Published: October 2021

Abstract
The association between oxidative stress and endocrine status with respect to the role of Pterocarpus santalinus (PSE) against alcohol-induced neurotoxicity in rats was investigated. Male albino rats were divided into, control, alcohol treated, alcohol + PSE treated, and PSE treated group. Twenty percent of ethanol (5g/kg body weight/day) was given with and without PSE (250 mg/kg body weight/day) for 60 days. Decreased plasma testosterone, estradiol, thyroid hormones (T3 and T4), and increased cortisol concentrations in alcohol treated rats were observed. Besides, elevated lipid peroxidation, protein carbonyls, NADPH oxidase (NOX), and cytochrome P-450 (CYP-450) activities, with mitochondrial dysfunction were noticed. Moreover, increased protein expression of the phosphorylated protein kinase C (p-PKC), phospholipase C (p-PLC), and NOX2 with decreased antioxidant status was also noticed in alcohol ingested rats. Administration of PSE to alcohol treated rats reduced oxidative stress by increasing antioxidant status, also modulated mitochondrial dysfunction and protein expression of p-PKC, p-PLC and NOX2. In conclusion, ROS generated via mitochondrial dysfunction causes activation of NOX activity through PLC and PKC dependent pathways leading to more ROS generation, which in turn alters the circulating hormonal levels. The phytocompounds present in PSE confer therapeutic efficacy by scavenging ROS and thereby offer protection.
Development of An Environmental-Friendly Durable Concrete
Authors: TRIPATHI DEEP , Kumar Rakesh , Mehta Pradeep Kumar 
Published: October 2021

Abstract
In this experimental study on Self Compacting Concrete (SCC), the Manufactured sand (M-sand) and Fly ash (FA) were utilised for partial replacement of Natural sand (N-sand) and Ordinary Portland Cement (OPC), respectively. N-sand was partially replaced by M-sand at various percentage levels, after the dose of FA in the mix was optimized. In terms of compressive strength, the optimum replacement level of OPC by FA was 20%, while for replacement of N-sand by M-sand it was 50%. Two types of mixes were made to compare the macro and micro level properties of SCC, i.e., SCC-I (100%OPC+100%N-sand), and SCC-II (80%OPC+20%FA+50%N-sand+50%M-sand). The characteristics of fresh concrete mixes were determined using Slump flow, T50 time, V-funnel, L-box, U-box, and J-ring tests. After 28 days of curing in tap water, both type of specimens were exposed in solution of Ammonium Sulphate [(NH4)2SO4] containing Sulphate salt concentration of 2.0g/l for 360 days to test their durability. Loss in compressive strength, weight change, sorptivity, and micro-structural changes (XRD, SEM, and EDS) all were evaluated up to 360 days. It was found that the use of FA and M-sand in concrete makes it more environment friendly and durable, as well as having higher performance in a sulphate environment.
Thinking It’s a Male Rather Than a Female Is More Likely and Quicker, Ceteris Paribus
Authors: Federici Stefano , Lepri Alessandro , Bacci Silvia , Bartolucci Francesco 
Published: October 2021

Abstract
According to previous ethnomethodological and cognitive studies on sex assignment, if a figure has male sexual characteristics people are more likely to think it is a man than a woman when the figure has female ones. This male attribution bias is definitely reinforced when a penis is apparent in human nude images. We reported findings of three experiments aimed at replicating previous studies by administering the Sex/Gender Attribution Test for Adult (SGAT-A) created by digitally morphing bodies of two human male and female models into realistic images. We observed the sex attribution and response time of 1,706 young adult participants. A cross-cultural comparison was also carried out with a sample of young adult Chinese students. Findings substantially reconfirmed those obtained in previous studies. When male external genitalia were exposed, the odds of male sex attribution were 5.688 compared to 1.823 female attribution when female external genitalia were shown. The male external genitalia overshadow any other features that might rather suggest a female identity. The shortest response times were observed with masculine stimuli. Evolutionary and cultural determinants of the male sex bias are discussed.