bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating Competitive Li+ Coordination with Immobilized Anions in Composite Solid Electrolyte for High‐Performance Li Metal Batteries
Authors: Liang Ziyang , Liu Chang , Bai Xiang , Zhang Jiahui , Chang Xinyue , Zhang Bo , Xia Mengxue , Du Huayun , Huang Hao , Wu Bing , Yang Chengkai , Wang Shi , Liu Wen , Wang Qian 
Published: February 2025

AbstractPoly(vinylidene fluoride) (PVDF)‐based polymer electrolytes have attracted widespread attention due to their unique Li+ transport mechanism. However, their low ionic conductivity and porous structure, as well as residual solvent limit their application at high current densities. Here, a composite solid electrolyte (CSE) is developed by integrating poly(vinylidene‐co‐trifluoroethylene) [P(VDF‐TrFE)] in its all‐trans conformation with aminofunctionalized metal–organic framework (ZIF‐90‐NH2). In such a CSE, all F atoms located on one side of the polymer chain, providing fast Li+ transport channels. Concurrently, the functionalized ZIF‐90‐NH2 can effectively anchor the residual N, N‐dimethylformamide (DMF) in CSEs while weakening Li+‐DMF solvent coordination, inducing the rearrangement of Li+ solvation structure and inhibiting the decomposition of DMF at the interface. Synergistically, ZIF‐90‐NH2 can immobilize anions in Li salts, promoting their dissociation. Based on integrating competitive Li+ coordination with immobilized anions, the obtained CSEs exhibit a high Li+ transference number (0.77). The full cells with LiFePO4 cathode can run stably over 400 cycles at 5 C, while the Li || LiNi0.7Co0.1Mn0.2O2 full cells deliver a high capacity retention (>85%) after 200 cycles at a charge cutoff voltage of 4.5 V. This work opens up a new path for building CSEs with high interfacial stability and fast Li+ transport.
Pioneering Insights into the Reaction Kinetics of Metastable Intermolecular Composites Based on Metal Fluorides: Virtually non‐existent condensed Phase Combustion Products and Ultra‐Efficient Reactivity
Authors: Liu Xuwen , Li Jingwei , Feng Shenghua , Jia Yongsheng , Hu Maocong , Yao Yingkang , Sun Jinshan , Xie Quanmin , Sang Hongqian 
Published: February 2025

AbstractAs a typical representative of Metastable intermolecular composites (MICs), the energy release of nano‐thermites relying on aluminum‐oxygen reaction is limited by the formation of high boiling point condensed phase products. Low pressure output performance constitutes another pivotal factor influencing their efficacy. In this work, metal fluorides BiF3 at different scales were incorporated into nano‐thermites as oxidants, thereby facilitating the tunability of the released energy. The boiling points of all resultant reaction products fall below the combustion temperature, theoretically abolishing the agglomeration of condensed‐phase products, thus preventing the entrapment of active metals. Additionally, it facilitates the smooth conduction of heat flux, thereby averting losses in biphasic flow dynamics. The n‐Al/n‐BiF3 system exhibits a significant amplification in reactive kinetic properties in stark contrast to the n‐Al/n‐Bi2O3 system. The reduction in ignition threshold is ascribed to a novel reaction kinetics mechanism within the n‐Al/BiF3 system. The highly electronegative fluorine within BiF3 corrodes the Al2O3 shell, inducing a “pre‐ignition” reaction. The application of Density Functional Theory (DFT) evaluations has further corroborated the n‐Al/n‐BiF3 system's preeminence in electron transfer capacity between the oxidizing agent and fuel, thereby furnishing an molecular‐electronic basis for its potent reactive kinetic properties.
Behavioral Abnormalities, Cognitive Impairments, Synaptic Deficits, and Gene Replacement Therapy in a CRISPR Engineered Rat Model of 5p15.2 Deletion Associated With Cri du Chat Syndrome
Authors: Shen Jingjing , Wang Yan , Liu Yang , Lan Junying , Long Shuang , Li Yingbo , Chen Di , Yu Peng , Zhao Jing , Wang Yongjun , Wang Shali , Yang Feng 
Published: February 2025

AbstractThe Cri du Chat Syndrome (CdCS), a devastating genetic disorder caused by a deletion on chromosome 5p, faces challenges in finding effective treatments and accurate animal models. Using CRISPR‐Cas9, a novel CdCS rat model with a 2q22 deletion is developed, mirroring a common genetic alteration in CdCS patients. This model exhibits pronounced deficits in social behavior, cognition, and anxiety, accompanied by neuronal abnormalities and immune dysregulation in key brain regions such as the hippocampus and medial prefrontal cortex (mPFC). The immunostaining and RNA‐seq analyses provide new insights into CdCS pathogenesis, revealing inflammatory and immune processes. Importantly, it is demonstrated that early gene replacement therapy with AAV‐Ctnnd2 alleviates cognitive impairments in CdCS rats, highlighting the potential for early intervention. However, the effectiveness of this therapy is confined to the early developmental stages and does not fully restore all CdCS symptoms. The findings deepen the understanding of CdCS pathogenesis and suggest promising therapeutic directions.
Generation of Site‐Specifically Labeled Affinity Reagents via Use of a Self‐Labeling Single Domain Antibody
Authors: Fayn Stanley , Roy Swarnali , Cabalteja Chino C. , Lee Woonghee , Makala Hima , Baidoo Kwamena , Nambiar Divya , Sheehan‐Klenk Julia , Chung Joon‐Yong , Buffington Jesse , Ho Mitchell , Escorcia Freddy E. , Cheloha Ross W. 
Published: February 2025

AbstractSeveral chemical and enzymatic methods have been used to link antibodies to moieties that facilitate visualization of cognate targets. Emerging evidence suggests that the extent of labeling, dictated by the type of chemistry used, has a substantial impact on performance, especially in the context of antibodies used for the visualization of tumors in vivo. These effects are particularly pronounced in studies using small antibody fragments, such as single‐domain antibodies, or nanobodies. Here, we leverage a new variety of conjugation chemistry, based on a nanobody that forms a crosslink with a specialized high‐affinity epitope analogue, to label target‐specific nanobody constructs with functionalities of choice, including fluorophores, chelators, and click chemistry handles. Using heterodimeric nanobody conjugates, comprised of an antigen recognition module and a self‐labeling module, enables us to attach the desired functional group at a location distal to the site of antigen recognition. Constructs generated using this approach bound to antigens expressed on xenograft murine models of liver cancer and allowed for non‐invasive diagnostic imaging. The modularity of our approach using a self‐labeling nanobody offers a novel method for site‐specific functionalization of biomolecules and can be extended to other applications for which covalent labeling is required.
GPR37 Activation Alleviates Bone Cancer Pain via the Inhibition of Osteoclastogenesis and Neuronal Hyperexcitability
Authors: Wang Kaiyuan , Zhang Yongfang , Shu Ruichen , Yuan Limei , Tu Huifang , Wang Shengran , Ni Bo , Zhang Yi‐Fan , Jiang Changyu , Luo Yuhui , Yin Yiqing 
Published: February 2025

AbstractOsteolytic bone cancer pain is a primary concern for cancer patients with bone metastasis, and current therapies offer inadequate pain relief. The present study demonstrates that activation of the G protein‐coupled receptor 37 (GPR37) by neuroprotectin D1 (NPD1) or artesunate (ARU) alleviates both acute and persistent pain in multiple mouse models of bone cancer. GPR37 agonists also protect against cancer‐induced bone destruction. Mechanistically, NPD1 or ARU binding to GPR37 in macrophages promotes the release of IL‐10, which further inhibits cancer‐induced osteoclastogenesis. Moreover, direct activation of GPR37 in dorsal root ganglion (DRG) neurons and the spinal dorsal horn reduces action potential firing and the frequency of spontaneous excitatory postsynaptic currents (sEPSCs), thereby suppressing cancer‐induced neuronal hyperexcitability. Importantly, the analgesic and protective effects of NPD1 and ARU are abolished in Gpr37−/− mice, and β‐arrestin 2 is identified as a key mediator in IL‐10 release and neuronal inhibition. In patients with bone metastases, plasma levels of endogenous NPD1 are negatively correlated with both pain intensity and the bone resorption marker CTX‐I. Collectively, these findings highlight GPR37 activation as a potential therapeutic strategy for alleviating bone cancer pain through direct and synergistic inhibition of osteoclastogenesis and neuronal hyperexcitability.
Carnosic Acid Directly Targets STING C‐Terminal Tail to Improve STING‐Mediated Inflammatory Diseases
Authors: Mu Wenqing , Xu Guang , Li Ling , Wen Jincai , Xiu Ye , Zhao Jia , Liu Tingting , Wei Ziying , Luo Wei , Yang Huijie , Wu Zhixin , Zhan Xiaoyan , Xiao Xiaohe , Bai Zhaofang 
Published: February 2025

AbstractcGAS (cyclic GMP‐AMP synthase)‐STING (stimulator of interferon genes) signaling plays a vital role in innate immunity, while its deregulation may lead to a wide variety of autoinflammatory and autoimmune diseases. It is essential to identify specifically effective lead compounds to inhibit the signaling. Herein, it is shown that carnosic acid (CA), an active ingredient of medicinal plant Rosmarinus officinalis L., specifically suppressed cGAS‐STING pathway activation and the subsequent inflammatory responses. Mechanistically, CA directly bound to STING C‐terminal tail (CTT), impeded the recruitment of TANK‐binding kinase 1 (TBK1) onto STING signalosome, thereby blocking the phosphorylation of STING and interferon regulatory factor 3 (IRF3) nuclear translocation. Importantly, CA dramatically attenuated STING‐mediated inflammatory responses in vivo. Consistently, CA has a salient ameliorative effect on autoinflammatory disease model mediated by Trex1 deficiency, via inhibition of the cGAS‐STING signaling. Notably, the study further indicates that phenolic hydroxyl groups are essential for CA‐mediated STING inhibitory activity. Collectively, the results thus identify STING as one of the crucial targets of CA for mediating CA's anti‐inflammatory activity, and further reveal that STING CTT may be a novel promising target for drug development.
High Output Voltage Aqueous Supercapacitors by Water Deactivated Electrolyte over Wide Temperature Range
Authors: Wang Hongji , Liu Wenpeng , Huang Jin , Xiao Tianliang , Lei Wenwei , Gao Faming , Liu Mingjie 
Published: February 2025

AbstractConfined by factors such as low operating voltage, poor temperature resistance, and instability at high voltage, the energy density of conventional symmetric aqueous supercapacitors is undesirable over a wide temperature range. It is still challenging to develop aqueous flexible supercapacitors (AFSCs) that can provide stable and high voltage output (>2.0 V) at extreme ambient temperatures. Here, a strategy for constructing AFSC with ultrahigh output voltages over a wide temperature range is proposed through the development of organohydrogel electrolytes (OHEs) with excellent water deactivation, which achieve a notable output voltage of 3.0 V, and unprecedented energy densities of 23.16 µWh cm−2 at −40 °C (beyond 25 °C), surpassing the performance of all previously reported symmetric supercapacitors with aqueous electrolytes. Theoretical calculations and experimental analyses show that OHEs can deactivate water to increase the output voltage limit of AFSCs by enhancing intermolecular interactions and regulating inter Helmholtz plane. Meanwhile, it also shows excellent flexibility and cycling stability (80.5% after 20 000 cycles at 25 °C and 97.0% after 50 000 cycles at −40 °C). More importantly, OHEs enable AFSCs switchable output voltages (from 2.5 to 3.0 V), making it possible to operate supercapacitors with high energy density and stability at low temperatures.
Oxygen‐Crosslinker Effect on the Electrochemical Characteristics of Asphalt‐Based Hard Carbon Anodes for Sodium‐Ion Batteries
Authors: Wang Laibin , Xu Zikang , Lin Ping , Zhong Yu , Wang Xiuli , Yuan Yongfeng , Tu Jiangping 
Published: February 2025

AbstractBecause direct carbonation of asphalt usually yields ordered graphite structure with unfavorable storage of sodium. Here, the asphalt preoxidation at a specific temperature in the air introduces oxygen‐containing groups to connect the unsaturated aliphatic hydrocarbon and aromatic side chains, forming a disordered carbon skeleton to inhibit melting and rearrangement during carbonization. The abundant oxygen‐containing groups hinder the growth of the carbon layers during pyrolysis, which promotes the formation of disordered phases and abundant micropores in asphalt‐based hard carbons (HCs). The simultaneous increase in initial coulombic efficiency, capacity, and transport behavior of sodium ions in HCs is achieved by adjusting the carbon layer and micropore evolution. The optimized HCs display excellent initial coulombic efficiency of 86.14% with remarkable reversible capacity of 313.83 mAh g−1 at 0.1 C and high‐rate capability with 140 mAh g−1 at 5 C. Pairing with O3‐NaNi1/3Fe1/3Mn1/3O2 cathode, the full cell delivers a higher reversible capacity of 255.7 mAh g−1 with an initial coulombic efficiency of 83.7% and long cycle life. Based on the microstructure and electrochemical behaviors of asphalt‐based HCs, the “adsorption‐insertion‐pores‐filling” sodium storage mechanism is proposed, providing guidelines for designing high‐energy‐density sodium‐ion batteries.
U.S.–China agricultural trade and environmental outcomes: The case of nutrient runoff to the Gulf of Mexico
Authors: Xu Yuelu , Elbakidze Levan , Gassman Philip W. , Yen Haw , Ma Yongxi , Hubbart Jason A. , Arnold Jeffery G. 
Published: February 2025

AbstractWe quantify the relationship between nitrogen (N) runoff to the Gulf of Mexico, U.S. agricultural production, and exports to China using an integrated assessment model. We show that a 25% Chinese tariff on U.S. soybean and corn increases annual N runoff to the Gulf by 800 metric tons (0.2%) as soybean production in the Mississippi River Basin is displaced with more N‐intensive crops. Results also indicate that reducing N runoff to the Gulf by 10% decreases U.S. corn export to China by 14.5%, similar to the effect of a 25% Chinese tariff on corn and soybeans.
Water pricing and markets: Principles, practices and proposals
Authors: Wheeler Sarah Ann , Nauges Céline , Grafton R. Quentin 
Published: February 2025

AbstractThe allocation of water across space and time is a key challenge of water governance, with demand and supply often not well matched over time and place. Best practice water pricing and markets may promote water conservation, yet their application is limited. We highlight the governance principles needed for best practice water pricing and water markets, describe differences across regions, and provide six key water demand governance recommendations for both Global North and Global South countries.
Modeling and numerical simulation of concentrated solar energy storage using fluidized bed systems
Authors: Gao Zeyuan , Abbasian Javad , Arastoopour Hamid 
Published: February 2025

AbstractOne of the challenges to using concentrated solar energy (CSE) is the development of innovative fluids or mixtures of fluid and particle systems to efficiently adsorb concentrated solar radiation and transfer heat. In this article, the large‐eddy simulation (LES) model and a computational fluid dynamics (CFD) approach were used to simulate CSE absorption by a fluidized bed of silicon carbide (SiC). Drag‐forced modification was developed based on the Clark sub‐grid model for fluidized beds. The result of our two‐dimensional simulation agreed well with Tregambi et al. experimental data. Our simulation showed that the fluidized bed reduced the surface temperature by convective energy transfer, which is only on the surface for the incipiently fluidized bed and in the entire fluidized bed for the bubbling fluidized bed due to the mixing created by bubbles. The lower temperature on the surface significantly decreased the radiative energy loss from the surface to the environment.
Optimization of pharmaceutical supply chains: Navigating disruptions and operational uncertainty utilizing risk measures
Authors: Badejo Oluwadare , Ierapetritou Marianthi 
Published: February 2025

AbstractOperational uncertainties and disruptions present significant challenges in maintaining the resilience and sustainability of pharmaceutical supply chains. Ensuring efficient operations, minimizing emissions, and enhancing distribution reliability are essential for sustainable supply chain performance. This work examines the challenges posed by uncertainty and disruption in the pharmaceutical supply chain, utilizing stochastic optimization and downside risk to formulate mitigation strategies. Specifically, the study compares the solutions of risk‐neutral and risk‐averse objectives across three key areas: cost, environmental impact, and service level. Solutions from each approach highlight trade‐offs: the risk‐neutral solution offers better objective values, while the risk‐averse one ensures robustness across scenarios but at a higher cost. The multiobjective analysis demonstrates that considering risk is advantageous, as the benefits of robustness outweigh the associated costs. Overall, the results highlight that risk‐averse optimization offers strategic advantages for developing robust and sustainable pharmaceutical supply chains in the face of uncertainty and disruption.
Generalized optimization framework for synthesis of thermally coupled distillation columns
Authors: Liu Chao , Ma Yingjie , Li Jie 
Published: February 2025

AbstractIn this article, a generalized optimization framework is proposed for the synthesis of thermally coupled distillation systems within an equation‐oriented environment. The proposed framework consists of three components: an efficient superstructure representation, a novel mathematical formulation, and the associated solution algorithm, encompassing a broad range of alternatives. The mathematical model is developed using conditional statements to activate specific sets of equations, effectively addressing existing zero‐flow issues. The synthesis problem is formulated as a Mixed Integer Nonlinear Programming problem, which is optimized using our previously developed Feasible Path‐Based Branch and Bound method, coupled with an improved Sequential Quadratic Programming algorithm. The computational studies demonstrate that the proposed optimization framework successfully solves complex benchmark problems for separating zeotropic multicomponent mixtures within reasonable computational time with good convergence performance from easily selected starting points. The optimal configuration generated leads to a reduction in total annualized cost ranging from 3.5% to 45%.
The role of immunohistochemistry staining and hematoxylin & eosin staining in the diagnosis of cytomegalovirus disease of the gastrointestinal tract
Authors: Yeh Pai‐Jui , Wu Ren‐Chin , Chen Chien‐Ming , Le Puo‐Hsien 
Published: February 2025

AbstractInvasive cytomegalovirus (CMV) diseases require accurate diagnosis. However, study evaluating the accuracy of hematoxylin and eosin (H&E) staining and the necessity of immunohistochemistry (IHC) staining in different CMV diseases of the gastrointestinal (GI) tract is limited. We analyzed specimens of the GI tract with H&E and IHC staining results from the pathology database. Patients were divided into suspected CMV infection (HEs) and no evidence of CMV infection (HEn) groups. We used IHC staining as the gold standard and analyzed sensitivity (SE), specificity (SP), positive predictive value (PPV), and negative predictive value (NPV) for H&E staining. Among 1448 specimens, the SE/SP (%) of H&E staining for the entire tract, esophagus, stomach, small intestine, and colon were 76.1%/82.1%, 76.1%/70%, 85.5%/71.7%, 60%/94.2%, and 75%/87%; the PPV/NPV (%) in the same order were 58%/91.3%, 39.3%/92%, 51.2%/93.5%, 69.2%/91.5%, and 68%/90.4%. In conclusion, for patients exhibiting high clinical suspicion, the application of IHC staining is essential in achieving an accurate diagnosis.
Can biocrust moss hide from climate change? Fine‐scale habitat sheltering improves summer stress resistance in Syntrichia caninervis
Authors: Clark Theresa A. , Russell Alexander , Greenwood Joshua L. , Devitt Dale , Stanton Daniel , Stark Lloyd R. 
Published: February 2025

AbstractPremiseMosses provide many ecosystem functions and are the most vulnerable of biocrust organisms to climate change due to their sensitive water relations stressed by summer aridity. Given their small size, moss stress resistance may be more dependent on fine‐scale habitat than macroclimate, but the sheltering role of habitat (i.e., habitat buffering) has never been compared to macroclimate and may have important implications for predicting critical biocrust moss refugia in changing climates.MethodsWe located three populations of a keystone biocrust moss, Syntrichia caninervis, spanning 1200 m of altitude, which comprised three macroclimate (elevation) zones of characterized plant communities in the Mojave Desert. We stratified 92 microsites along three aridity gradients: elevation zone, topography (aspect), and microhabitat (shrub proximity). We estimated summer photosynthetic stress (Fv/Fm) and aridity exposure (macroclimate, irradiance, and shade).ResultsMicrosite aridity exposure varied greatly, revealing exposed and buffered microhabitats at all three elevation zones. Moss stress did not differ by elevation zone despite the extensive macroclimate gradient, failing to support the high‐elevation refugia hypothesis. Instead, stress was lowest on northerly‐facing slopes and in microhabitats with greater shrub shading, while the importance of (and interactions between) topography, irradiance, and shade varied by elevation zone.ConclusionsFine‐scale habitat structure appears physiologically more protective than high‐elevation macroclimate and may protect some biocrust mosses from the brunt of climate change in widespread microrefugia throughout their current ranges. Our findings support a scale‐focused vulnerability paradigm: microrefugia may be more important than macrorefugia for bolstering biocrust moss resistance to summer climate stress.