bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparison of the vancomycin calcium sulfate implantation versus fenestration decompression for the treatment of sclerosing osteomyelitis
Authors: Hua Haotian , Wang Xinwei , Guo Jiangang , Zhang Lei , Guo Zairan , Chen Jiangfei 
Published: November 2021

Abstract
Objective
To compare the clinical efficacy of vancomycin calcium sulfate implantation and fenestration decompression in the treatment of sclerosing osteomyelitis.

Method
A retrospective analysis for 46 cases of sclerosing osteomyelitis
were admitted to our department between June 2010 to June 2020. Twenty-one patients were treated with fenestration decompression, twenty-five patients were treated with vancomycin calcium sulfate implantation. The postoperative hospital stay, days of drainage tube placement, visual analogue scale scores, C-reactive protein and erythrocyte sedimentation rate were compared between the two groups.

Results
The visual analogue scale scores of both groups were significantly lower than before treatment (p < 0.05), but the difference between them was not statistically significant. Patients treated by vancomycin calcium sulfate implantation had shorter postoperative hospital stay and days of drainage tube placement compared to those treated by fenestration decompression (p < 0.05). C-reactive protein and erythrocyte sedimentation rate in both groups were significantly lower than before treatment, but the improvement effect of vancomycin calcium sulfate implantation was better (p < 0.05).

Conclusion
Both treatment methods can relieve pain effectively. Compared with fenestration decompression, vancomycin calcium sulfate implantation can shorten the treatment time effectively, control the infection better.
Umbilical cord blood stem cells transplantation in a patient with severe progressive supranuclear palsy: a case report
Authors: Li Huiping , Yuan Fang , Du Yaming , Pan Tao , Wen Wanxin , Li Shaoxue , Wang Lixin , Lu Aili 
Published: November 2021

Abstract
Background
Progressive supranuclear palsy is a neurodegenerative condition that worsens over time. Given the lack of targeted treatments, patients with severe progressive supranuclear palsy have very low life expectancy.

Case presentation
We present a case of a 61-year-old Chinese man with severe progressive supranuclear palsy and treated with umbilical cord blood stem cells transplantation. After the umbilical cord blood stem cells therapy, his neurologic symptoms stopped deteriorating, his muscle rigidity was mildly improved, and he remains alive for more than 8 years.

Conclusions
Umbilical cord blood stem cells transplantation may be an alternative therapy for patients with severe progressive supranuclear palsy.
Burden of puerperal sepsis and its associated factors in Ethiopia: a systematic review and meta-analysis
Authors: Melkie Abenezer , Dagnew Enyew 
Published: November 2021

Abstract
Background
Puerperal sepsis is a genital tract infection that can occur from amniotic fluid rupture to six weeks after birth. Maternal complication associated with puerperal sepsis includes prolonged hospital stay, septicemia, disseminated intravascular coagulation, pelvic inflammatory disease, infertility, and death. Even though, puerperal sepsis is the fourth leading cause of maternal morbidity and mortality in Ethiopia the overall prevalence of puerperal sepsis and its associated factors are not studied at the national stage. As a result, this systematic review and meta-analysis bring out the pooled prevalence of puerperal sepsis and its associated factors in Ethiopia.

Methods
A variety of data sources such as Pub Med, Web of Science, Science Direct, Embase, Google Scholar, HINARI, and Ethiopian universities online repositories were searched to identify the primary studies which were used for this systematic review and meta-analysis. The article search was conducted from February10/2021-March 10/2021. The quality of the selected primary studies was assessed using the Newcastle - Ottawa quality assessment Scale (NOS). Data extraction was done with Microsoft Excel and then exported to STATA 11 version statistical software for analysis. The Cochran (Q-test) and I2 test statistics were used to assess the heterogeneity of the studies. Publication bias was evaluated by the eggers regression test. Subgroup analysis was performed with region and sample size category.

Result
In this review, a total of 2222 respondents were involved from seven studies. The pooled prevalence of puerperal sepsis was 14.811% (95%CI; 8.46: 21.16; I2 = 94.2, P ≤ 0.001). Cesarean section delivery (CSD) (OR = 3.26, 95%CI: 1.90, 5.61), membrane rupture≥24 h (OR = 4.04, 95%CI: 2.54, 6.42), being multiparous mother (OR = 3.99, 95%CI: 1.82, 8.78), vaginal examination≥5 times (OR = 3.15, 95%CI: 1.17, 8.52), and anemia (OR = 5.68, 95%CI: 4.38, 7.36) were factors significantly associated with puerperal sepsis.

Conclusion
The prevalence of puerperal sepsis was high in Ethiopia. CSD, membrane rupture≥24 h, being multiparous mother, vaginal examination≥5, and anemia were factors associated with puerperal sepsis. Appropriate standard infection prevention techniques during CSD shall be practiced to reduce the maternal burden of puerperal sepsis. The unnecessary vaginal examination should be discouraged during the intrapartum period. Besides this, routine Iron sulfate supplementation and counsel on iron reach foods during ante partum and postpartum shall be considered for all mothers.
Potential of shea fruit-based ingredients for the feed industry
Authors: Donkor Martin Ntiamoah , Mosobil Richard , Abaah Eunice A. , Kanati Cephas , Akabanda Fortune , Donkor Addai-Mensah 
Published: November 2021

Abstract
Background
The cost involved in feeding poultry is very high especially in most developing countries. To this end, the effectiveness of the fruit pulp of Vitellaria paradoxa (shea), an agro-industrial by-product that is discarded in the processing of the nut for shea butter extraction was investigated on twelve poultry birds assigned to three groups A, B and C (control). Dried samples of the fruit pulp were analysed for their nutrients.

Results
Proximate analysis of the shea fruit pulp revealed a carbohydrate content of 41.14%, crude fibre 26.62%, crude protein 10.34%, ash 9.23%, crude fat 3.55% and 9.13% for moisture. It also contained essential minerals such as Ca (587 mg /100 g dw), Na (138.30 mg /100 g dw), Mg (1358 mg /100 g dw), K (771.5 mg /100 g dw), Fe (29.88 mg/100 g dw), Zn (40.31 mg/100 g dw) and Cu (8.11 mg/100 g dw). Heavy metals such as Cd, Mn, Pb and Cr were below detectable limits. Measured parameters were live body weights and some selected blood chemistry tests. Broilers in groups A and B fed on shea fruit pulp formulated with maize meal showed a significant growth performance in weight (p < 0.05) as compared to group C fed on maize meal only. Selected blood chemistry tests carried out included Ca, Na, K, Albumin, Triglyceride and Chloride. Statistical analysis showed that formulated feed had a significant effect (p < 0.05) on blood chemistry values of broilers, however, there was an insignificant effect (p > 0.05) in the control group, fed on maize meal only.

Conclusion
The fruit pulp of Vitellaria paradoxa could be considered a good source of macro and micronutrients and could be used as a supplement in poultry feed.
In vitro biosynthesis of ATP from adenosine and polyphosphate
Authors: Sun Chuanqi , Li Zonglin , Ning Xiao , Xu Wentian , Li Zhimin 
Published: November 2021

AbstractAdenosine triphosphate (ATP) acts as a crucial energy currency in vivo, and it is a widely used energy and/or phosphate donor for enzyme-catalyzed reactions in vitro. In this study, we established an in vitro multi-enzyme cascade system for ATP production. Using adenosine and inorganic polyphosphate (polyP) as key substrates, we combined adenosine kinase and two functionally distinct polyphosphate kinases (PPKs) in a one-pot reaction to achieve chain-like ATP regeneration and production. Several sources of PPK were screened and characterized, and two suitable PPKs were selected to achieve high rates of ATP production. Among these, Sulfurovum lithotrophicum PPK (SlPPK) exhibited excellent activity over a wide pH range (pH 4.0–9.0) and synthesized ATP from ADP using short-chain polyP. Furthermore, it had a half-life > 155.6 h at 45 °C. After optimizing the reaction conditions, we finally carried out the coupling-catalyzed reaction with different initial adenosine concentrations of 10, 20, and 30 mM. The highest yields of ATP were 76.0, 70.5, and 61.3%, respectively.
Graphical Abstract
Laparoscopic remnant cholecystectomy for calculi in the remnant gallbladder following subtotal-cholecystectomy: a report of two cases
Authors: Utsunomiya Takeshi , Sakamoto Katsunori , Sogabe Kyousei , Takenaka Ryoichi , Hayashi Tatsuya , Ogura Fumiya , Yamamoto Hisato , Ishida Naoki , Nakamura Taro , Sakamoto Akimasa , Iwata Miku , Ito Chihiro , Matsui Takashi , Nishi Yusuke , Shine Mikiya , Uraoka Mio , Nagaoka Tomoyuki , Tamura Kei , Funamizu Naotake , Ogawa Kohei , Takada Yasutsugu 
Published: November 2021

AbstractTwo cases of laparoscopic remnant cholecystectomy using near-infrared fluorescence cholangiography (NIFC) for remnant gallbladder calculi following subtotal-cholecystectomy are reported. Case 1: a 36-year-old woman was referred to our hospital with acute abdomen. Computed tomography showed remnant gallbladder calculi, with detected no other findings as the cause of the abdominal pain. For intraoperative exploration of the biliary anatomy, 0.25 mg/kg of indocyanine green (ICG) was administered intravenously the day before the operation. NIFC clearly showed the common bile duct and enabled safe laparoscopic remnant cholecystectomy. She was free from symptoms after the operation. Case 2: a 40-year-old woman was referred to our hospital with epigastralgia due to remnant gallbladder calculi after open cholecystectomy. ICG was administered intravenously the day before the operation. Severe adhesions were observed in the upper abdominal cavity and there was tight adherence of the duodenum to the remnant gallbladder. NIFC showed a clear margin that appeared to be the margin between the duodenum and remnant gallbladder. However, dissection of the margin observed by NIFC caused perforation of the duodenum. The clear margin seen with NIFC was likely due to visualization of the gallbladder through the duodenum. Although NIFC is a useful modality for confirming the intraoperative biliary anatomy, it is important not to rely too heavily on NIFC alone, which may lead to misinterpretation of the anatomy.
Hair microscopy: an easy adjunct to diagnosis of systemic diseases in children
Authors: Bhattarai Dharmagat , Banday Aaqib Zaffar , Sadanand Rohit , Arora Kanika , Kaur Gurjit , Sharma Satish , Rawat Amit 
Published: November 2021

AbstractHair, having distinct stages of growth, is a dynamic component of the integumentary system. Nonetheless, derangement in its structure and growth pattern often provides vital clues for the diagnosis of systemic diseases. Assessment of the hair structure by various microscopy techniques is, hence, a valuable tool for the diagnosis of several systemic and cutaneous disorders. Systemic illnesses like Comel-Netherton syndrome, Griscelli syndrome, Chediak Higashi syndrome, and Menkes disease display pathognomonic findings on hair microscopy which, consequently, provide crucial evidence for disease diagnosis. With minimal training, light microscopy of the hair can easily be performed even by clinicians and other health care providers which can, thus, serve as a useful tool for disease diagnosis at the patient’s bedside. This is especially true for resource-constrained settings where access and availability of advanced investigations (like molecular diagnostics) is a major constraint. Despite its immense clinical utility and non-invasive nature, hair microscopy seems to be an underutilized diagnostic modality. Lack of awareness regarding the important findings on hair microscopy may be one of the crucial reasons for its underutilization. Herein, we, therefore, present a comprehensive overview of the available methods for hair microscopy and the pertinent findings that can be observed in various diseases.
Investigating the association between physical health comorbidities and disability in individuals with severe mental illness
Authors: Mirza Luwaiza , Das-Munshi Jayati , Chaturvedi Jaya , Wu Honghan , Kraljevic Zeljko , Searle Thomas , Shaari Shaweena , Mascio Aurelie , Skiada Naoko , Roberts Angus , Bean Daniel , Stewart Robert , Dobson Richard , Bendayan Rebecca 
Published: November 2021

Abstract

Background
Research suggests that an increased risk of physical comorbidities might have a key role in the association between severe mental illness (SMI) and disability. We examined the association between physical multimorbidity and disability in individuals with SMI.

Methods
Data were extracted from the clinical record interactive search system at South London and Maudsley Biomedical Research Centre. Our sample (n = 13,933) consisted of individuals who had received a primary or secondary SMI diagnosis between 2007 and 2018 and had available data for Health of Nations Outcome Scale (HoNOS) as disability measure. Physical comorbidities were defined using Chapters II–XIV of the International Classification of Diagnoses (ICD-10).

Results
More than 60 % of the sample had complex multimorbidity. The most common organ system affected were neurological (34.7%), dermatological (15.4%), and circulatory (14.8%). All specific comorbidities (ICD-10 Chapters) were associated with higher levels of disability, HoNOS total scores. Individuals with musculoskeletal, skin/dermatological, respiratory, endocrine, neurological, hematological, or circulatory disorders were found to be associated with significant difficulties associated with more than five HoNOS domains while others had a lower number of domains affected.

Conclusions
Individuals with SMI and musculoskeletal, skin/dermatological, respiratory, endocrine, neurological, hematological, or circulatory disorders are at higher risk of disability compared to those who do not have those comorbidities. Individuals with SMI and physical comorbidities are at greater risk of reporting difficulties associated with activities of daily living, hallucinations, and cognitive functioning. Therefore, these should be targeted for prevention and intervention programs.
The Affective Dominant: Affective Crisis and Contemporary Fiction
Authors: Demeyer Hans , Vitse Sven 
Published: November 2021

AbstractContemporary developments in fiction have so far primarily been interpreted as an attempt to move beyond postmodernism toward a renewed sense of realism and communication. This article suggests an alternative conceptualization and puts forward the hypothesis that contemporary fiction marks a shift toward an affective dominant. In Postmodernist Fiction (1987) Brian McHale defines the dominant as a structure that brings order and hierarchy in a diversity of techniques and motifs in a literary text. Whereas in modernism the dominant is epistemological and in postmodernism it is ontological, in contemporary literature we contend this dominant is affective. The prevailing questions are “How can I feel reality (myself, the other, the past, the present, etc.)?”; “How can I feel to belong to reality?”; and “How can I feel reality to be real?” This affective dominant manifests itself in motifs such as desire, attachment, fantasy, and identification. Formal and narrative devices that in modernist or postmodernist fiction contributed to an epistemological or ontological dominant tend to foreground questions of affectivity in contemporary fiction. Through the analysis of novels by Ben Lerner, Alejandro Zambra, and Zadie Smith this article substantiates this hypothesis. This approach allows us to study contemporary fiction both diachronically, in relation to postmodernism, and synchronically, in relation to its social and ideological context.
Cumulative Structure in Zhuangzi's “The Great and Venerable Teacher”
Authors: Lian Xinda 
Published: November 2021

Abstract
The secret of the “cumulative structure,” one of Zhuangzi's favorite rhetorical devices, is “adding.” To add is not to repeat but to arrange meanings of different shapes in various incremental parallel structures. This effective tool is used in his chapter titled “The Great and Venerable Teacher” to explicate the highest order of true understanding of the Way, or zhenzhi, and to symbolize the climactic pursuit of the Daoist truth. Vertically the Daoist epistemological value system, with the zhenzhi at its apex, is extended into a graphic hierarchy; horizontally the step-by-step progressive process of the attainment of this true knowledge is sometimes subjected to contemplative examination and sometimes compressed along the axle of time flow into an intense moment of sudden enlightenment. Since the cumulative structure works as a living body of correlation, the palpable contour of which corresponds to the message it conveys, it enables the readers to experience—not just to understand—Zhuangzi's teaching.
Between Colonialism and Despotism
Authors: Tuo Jianing 
Published: November 2021

Abstract
The Mengjiang 蒙疆 puppet regime was established in Inner Mongolia by Japanese colonizers, in collaboration with the Mongolian Prince Demchugdongrub, during the Second Sino-Japanese War. The Mengjiang regime tried to revive Mongolian culture in the name of resisting Chinese despotism. However, the Japanese supported the Mongols' desire for “self-determination” merely to use it as a vehicle for their colonial designs. Through a close reading of several texts that appeared in Sinophone magazines published in Japanese-occupied Inner Mongolia during the war, this article explicates the distinctions between Han writers' and Mongol intellectuals' nationalist writings, in order to theorize the dual oppression of the Mongol minority culture under Japanese colonialism and Chinese despotism. Despite the mission of this so-called Mongolian nation-state to write in a Mongolian style, the Han writers in Mengjiang expressed their ethnic identity through Sinophone literature; at the same time, Sinicized Mongol intellectuals failed to revive Mongolian culture through the same vehicle. In the end, both the former Han despots and the new Japanese colonizers tried to instrumentalize Mongol minority culture to establish their own cultural hegemony. Under this dual oppression of foreign colonialism and native despotism, the Sinophone nationalist writings of the Han majority and the Mongol minority problematize any simple binarism of colonizer and colonized.
The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds
Authors: Knudsen Dal Nils-Jørgen , Speth Martin , Johann Kerstin , Barz Matthias , Beauvineau Claire , Wohlmann Jens , Fenaroli Federico , Gicquel Brigitte , Griffiths Gareth , Alonso-Rodriguez Noelia 
Published: November 2021

ABSTRACT
With the increasing emergence of drug-resistant Mycobacterium tuberculosis strains, new and effective antibiotics against tuberculosis (TB) are urgently needed. However, the high frequency of poorly water-soluble compounds among hits in high-throughput drug screening campaigns is a major obstacle in drug discovery. Moreover, in vivo testing using conventional animal TB models, such as mice, is time consuming and costly, and represents a major bottleneck in lead compound discovery and development. Here, we report the use of the zebrafish embryo TB model for evaluating the in vivo toxicity and efficacy of five poorly water-soluble nitronaphthofuran derivatives, which were recently identified as possessing anti-TB activity in vitro. To aid solubilization, compounds were formulated in biocompatible polymeric micelles (PMs). Three of the five PM-formulated nitronaphthofuran derivatives showed low toxicity in vivo, significantly reduced bacterial burden and improved survival in infected zebrafish embryos. We propose the zebrafish embryo TB-model as a quick and sensitive tool for evaluating the in vivo toxicity and efficacy of new anti-TB compounds during early stages of drug development. Thus, this model is well suited for pinpointing promising compounds for further development.
The Value of Paratracheal Lymphadenectomy in Esophagectomy for Adenocarcinoma of the Esophagus or Gastroesophageal Junction: A Systematic Review of the Literature
Authors: Gantxegi Amaia , Kingma B. Feike , Ruurda Jelle P. , Nieuwenhuijzen Grard A. P. , Luyer Misha D. P. , van Hillegersberg Richard 
Published: November 2021

Abstract
Background
The role of upper mediastinal lymphadenectomy for distal esophageal or gastroesophageal junction (GEJ) adenocarcinomas remains a matter of debate. This systematic review aims to provide a comprehensive overview of evidence on the incidence of nodal metastases in the upper mediastinum following transthoracic esophagectomy for distal esophageal or GEJ adenocarcinoma.

Methods
A literature search was performed using Medline, Embase and Cochrane databases up to November 2020 to include studies on patients who underwent transthoracic esophagectomy with upper mediastinal lymphadenectomy for distal esophageal and/or GEJ adenocarcinoma. The primary endpoint was the incidence of metastatic nodes in the upper mediastinum based on pathological examination. Secondary endpoints were the definition of upper mediastinal lymphadenectomy, recurrent laryngeal nerve (RLN) palsy rate and survival.

Results
A total of 17 studies were included and the sample sizes ranged from 10-634 patients. Overall, the median incidence of upper mediastinal lymph node metastases was 10.0% (IQR 4.7-16.7). The incidences of upper mediastinal lymph node metastases were 8.3% in the 7 studies that included patients undergoing primary resection (IQR 2.0-16.6), 4,4% in the 1 study that provided neoadjuvant therapy to the full cohort, and 10.6% in the 9 studies that included patients undergoing esophagectomy either with or without neoadjuvant therapy (IQR 8.9-15.8%). Data on survival and RLN palsy rates were scarce and inconclusive.

Conclusions
The incidence of upper mediastinal lymph node metastases in distal esophageal adenocarcinoma is up to 10%. Morbidity should be weighed against potential impact on survival.
Conversion of natural forests to farmlands and its associated woody species diversity and carbon stocks in a span of 33 years (1984 to 2016): in the case of southwestern Ethiopia
Authors: Kefalew Tamiru , Betemariyam Mulugeta , Tolera Motuma 
Published: November 2021

BackgroundGura-Ferda forest is one of the Afromontane rainforests in the southwestern region of Ethiopia. However, since 1984, large parts of this forest have become increasingly disturbed and fragmented due to forest conversion into forest farm interface and farmlands. The study was conducted to assess changes of woody species diversity and carbon stock in association with the conversion of natural forest to forest farm interface and farmlands.MethodsData were collected from natural forest, forest farm interface and farmland which are historically forest lands before 1984. A total of 90 nested plots (20m×20m for natural forest and forest farm interface; 50m*100m for farmland)) were established for inventory of woody species. Three 1m×1m subplots were established to collect litter and soil samples. A total of 180 soil samples were collected. The total carbon stocks were estimated by summing carbon stock in the biomass and soil (0-60 cm depth).ResultsResults showed that Shannon-Wiener diversity (H’) in forest farm interface (H’ = 1.42±0.49) is significantly lower than that of natural forest (H’ = 2.72±0.31) but significantly higher than farmland (H’ = 1.08±0.57). The total carbon stocks of natural forest (388.54±161.63 Mg C ha-1) were approximately 1.53 and 2.67 times higher than that of forest farm interface (252.95±41.86 Mg C ha-1) and farmland (145.58±25.94 Mg C ha-1).ConclusionOur study revealed that along the conversion gradient of natural forest to forest farm interface and farmland there was a significant change of woody species diversity and carbon stocks.