bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency-Dependent Dynamics of Functional Connectivity Networks During Seizure Termination in Childhood Absence Epilepsy: A Magnetoencephalography Study
Authors: Sun Jintao , Li Yihan , Zhang Ke , Sun Yulei , Wang Yingfan , Miao Ailiang , Xiang Jing , Wang Xiaoshan 
Published: October 2021

Objective: Our aim was to investigate the dynamics of functional connectivity (FC) networks during seizure termination in patients with childhood absence epilepsy (CAE) using magnetoencephalography (MEG) and graph theory (GT) analysis.Methods: MEG data were recorded from 22 drug-naïve patients diagnosed with CAE. FC analysis was performed to evaluate the FC networks in seven frequency bands of the MEG data. GT analysis was used to assess the topological properties of FC networks in different frequency bands.Results: The patterns of FC networks involving the frontal cortex were altered significantly during seizure termination compared with those during the ictal period. Changes in the topological parameters of FC networks were observed in specific frequency bands during seizure termination compared with those in the ictal period. In addition, the connectivity strength at 250–500 Hz during the ictal period was negatively correlated with seizure frequency.Conclusions: FC networks associated with the frontal cortex were involved in the termination of absence seizures. The topological properties of FC networks in different frequency bands could be used as new biomarkers to characterize the dynamics of FC networks related to seizure termination.
Optimal blood management as priority route in cardiac surgery
Authors: Kupryashov А. А. , Samuilova О. V. , Samuilova D. Sh. 
Published: October 2021

Introduction. Generating manifold publications over decades, research continues assessing the burden of perioperative bleeding, preoperative anaemia and red blood component (RBC) transfusion in cardiac surgical patients. The past decade is witnessing a trend towards limited RBC transfusion. Nevertheless, the risk and justifi cation of a restrictive or liberal transfusion strategy in cardiac surgery remain a matter of debate.Aim — a description of evidence estimating the impact of bleeding, preoperative anaemia, red-cell transfusion and restrictive vs. liberal strategies on the risk of mortality and other adverse events in adults with cardiac surgery.Methods. Relevant evidence was mined in PubMed for the period 2012–2019. The query phrases were: cardiac surgery [кардиохирургия], bleeding [кровотечение], preoperative anaemia [предоперационная анемия], red-cell transfusion [переливание эритроцитов], restrictive and liberal transfusion strategy [рестриктивная и либеральная трансфузионная стратегия]. The review includes 18 studies describing outcomes related to bleeding, preoperative anaemia of varying severity and variant-volume RBC transfusion in patients with cardiac surgery. Nine studies comparatively assessed the cardiac surgical clinical outcomes under restrictive and liberal transfusion strategies. A total of 24 full texts have been analysed, one randomised clinical trial (RCT) summary, one retrospective trial summary and one meta-analysis review. Additional studies of concern to discussion have also been considered.Results. One prospective and four retrospective studies evaluated the effect of perioperative bleeding on the risk of subsequent adverse events in patients with cardiac surgery. Three prospective, fi ve retrospective studies and one RCT revealed the association of red-cell transfusion with adverse outcomes. Five retrospective studies exposed a link between preoperative anaemia and reason for RBC transfusions. Six retrospective studies found an independent association between the risk of postoperative complications and mortality in patients having cardiac surgery and preoperative anaemia. Eight RCTs and one meta-analysis of seven RCTs presented comparative data on clinical outcomes of restrictive and liberal transfusion strategies in patients after heart surgery.Conclusion. Preoperative anaemia, haemorrhage and donated component transfusion independently contribute to the risk of serious postoperative complications and death unifying in the “deadly triad” of cardiac surgery. RBC transfusions are integrally indicative of the aid quality in cardiac surgery reflecting the success of blood management system in the hospital. Leveraging a good patient blood management practice at all treatment steps to involve a multispecialty blood-team approach can significantly improve patient outcomes at a higher cost efficiency.
Clinical observation of chronic myeloid leukemia with variant translocation and supplementary rearrangement t(1;8)(q23;q24.3)
Authors: Assesorova Yu. Yu. , Mustafina L. K. , Yusupova S. A. , Samarina K. S. 
Published: October 2021

Introduction. Some patients with chronic myeloid leukemia (CML) have cytogenetically variant forms of translocation that lead to the formation of the coalesced BCR-ABL gene. The adverse course and progression of the disease are often accompanied by the appearance of additional chromosomal abnormalities in the karyotype of the patient.Aim — to describe a clinical observation of CML that occurred with the simultaneous presence of a variant translocation and a unique additional rearrangement in the patient’s karyotype.Main findings. A conventional cytogenetic analysis performed in a patient with primary immune thrombocytopenia and subsequently developed chronic myeloid leukemia revealed a variant translocation t(X;9;22)(q28;q34;q11.2), as well as an additional chromosomal anomaly t(1;8)(q23;q24.1). The presented case of observation shows that a standard cytogenetic study is an important part of the examination of patients with hematological pathologies, since it allows identifying chromosomal changes that have diagnostic and prognostic signifi cance.
Large B-cell lymphoma with IRF4 rearrangement
Authors: Plastinina L. V. , Moiseeva T. N. , Al-Radi L. S. , Kovrigina A. M. , Obukhova T. N. , Goryacheva S. R. , Shupletsova I. A. , Magomedova A. U. , Kravchenko S. K. 
Published: October 2021

Introduction. Large B-cell lymphoma with IRF4 rearrangement is rare disease, recently described in WHO 2017, arising in children and young adults, presenting with enlarged lymph nodes of the head and neck and/or Waldeyer ring. It is characterized by strong expression of MUM1 protein with IRF4 rearrangement.Aim — to present a clinical case of large B-cell lymphoma with IRF4 rearrangement and characterize its clinical, morphological, and cytogenetic features.Main findings. An observation of a patient with a rare case of large B-cell lymphoma with IRF4 rearrangement is presented.In-depth morphological, immunohistochemical analysis, and additional research methods made it possible to establish a correct diagnosis. Features of the case were the predominantly diffuse growth of large tumor cells in the lymph node biopsy with the indolent clinical course, and the presence of aberrations in both homologues of chromosome 6: IRF4 rearrangement and deletion 6p25. Treatment with 4 R-CHOP-21 courses allowed for the achievement of disease remission, which continued 26 months post treatment.
The formation of violin art in China
Authors: Тянь Лэй 
Published: October 2021

цель данного исследования – раскрытие особенности становления и развития скрипичного искусства, национального скрипичного репертуара, через тонкости взаимосвязи философии и музыки. Автор выделяет основные этапы в развитии скрипичного образования в Китае; характеризует деятельность выдающихся представителей скрипичного искусства в Китае на примере творчества Сянь Синьхая и Ма Сыцуна, анализирует формирование национального скрипичного репертуара.
the purpose of this study is to reveal the peculiarities of the formation and development of the violin art, the national violin repertoire, through the subtleties of the relationship between philosophy and music. The author identifies the main stages in the development of violin education in China; characterizes the activities of outstanding representatives of the violin art in China on the example of the works of Xiǎn Xīnghăi and Mǎ Sīcōng, analyzes the formation of the national violin repertoire.
Participatory practices in the context of socio-cultural revitalization (on the example of the "Artkommunalka Museum-Residence. Erofeev and others" in Kolomna)
Authors: Воробьева В.Д. 
Published: October 2021

в статье рассматриваются проекты по ревитализации наследия, влияющие на культурные процессы в городе. Организация деятельности подразумевает работу с локальным сообществом и развитие креативной среды путем создания арт-резиденций, включающих население города в партисипативную коммуникацию. Активное соучастие, основанное на общих интересах, ведет к позитивным преобразованиям в регионе, влияющих на улучшение экономических и социокультурных показателей.
the article discusses projects for the revitalization of heritage that affect the cultural processes in the city. The organization of activities includes work with the local community and the development of the creative environment, through the creation of art residences that include the population of the city in participatory communication. Active participation based on common interests leads to positive transformations in the region, affecting the improvement of economic and socio-cultural indicators.
Sociological analysis of distance learning in the educational space of the university on the example of the Moscow Pedagogical State University
Authors: Корнийчук М.С. , Белоусова О.И. 
Published: October 2021

современные дистанционные образовательные технологии открывают реальные перспективы для повышения качества знаний и оперативности образовательного процесса. Сегодня дистанционные образовательные услуги способны удовлетворить потребности в образовании, наращивать человеческий потенциал представителей всех социальных групп и слоев. В статье приводятся результаты проведенного при участии авторов социологического исследования, целью которого было выяснить, как студенты МПГУ оценивают дистанционное обучение, его удобство, а также выявить основные преимущества онлайн обучения. Проведенный анализ сложившейся в МПГУ системы дистанционного обучения показывает, что данная форма обучения перспективна. Однако онлайн-обучение не сможет полноценно заменить традиционное обучение.
modern distance learning technologies open real prospects for improving the quality of knowledge and efficiency of the educational process. Today, distance education services can meet the needs of education, to increase the human potential of representatives of all social groups and strata. The article presents the results of a sociological study (with the participation of the authors), the purpose of which was to find out how students at the Moscow Pedagogical State University evaluate distance learning, its convenience, as well as to identify the main advantages of online learning. The analysis of the existing system of distance learning in MPSU shows that this form of training is promising. However, online learning will not be a complete substitute for traditional learning.
Return to the specialty in the training of personnel in the UGSN 44.00.00 (Education and pedagogical sciences) as an opportunity to overcome the deficits of the Bologna system
Authors: Горохов С.А. , Луцькая Е.Е. 
Published: October 2021

в статье рассмотрены дефициты Болонской системы применительно к укрупненной группе специальностей и направлений (УГСН) подготовки 44.00.00 (Образование и педагогические науки). На основе проведенного анализа образовательных программ педагогического профиля авторы выдвигают ряд предложений, призванных обеспечить фундаментальность общей подготовки учителя и дать выпускнику возможность созреть в профессиональном плане, сформировать его мировоззрение и кругозор.
the article considers the deficits of the Bologna system in relation to the enlarged group of specialties and directions of training 44.00.00 (Education and pedagogical sciences). Based on the analysis of educational programs of the pedagogical profile, the authors put forward several proposals designed to ensure the fundamental nature of the general training of the teacher and give the graduate the opportunity to mature professionally, to form his worldview and outlook.
Stoma Bakım Becerisine Yönelik Bir Ölçme Aracı Geliştirme: Dereceli Puanlama Anahtarı
Authors: İNCESU Olga , ULUPINAR Sevim 
Published: October 2021

Amaç: Araştırmanın amacı, stoma bakım becerisine yönelik geçerli ve güvenilir bir ölçme aracı geliştirmektir.
Yöntem: Metodolojik tipteki çalışmanın örneklemini bir hemşirelik fakültesinde öğrenim gören, çalışmaya katılmaya gönüllü 116 hemşirelik öğrencisi oluşturdu. Araştırmacılar tarafından konuyla ilgili literatür taranarak madde havuzu oluşturuldu. Stoma bakım becerisi dereceli puanlama anahtarının kapsam ve içerik geçerliği için uzman görüşü alınarak kapsam geçerliği indeksi hesaplandı. Ölçeğin güvenirliği bağımsız gözlemciler arası uyum ve test-tekrar test analizi ile değerlendirildi.
Bulgular: Katılımcıların yaş ortalaması 20.16 yıl ve %71.6’sı kadındı. Uzman görüşü alınarak son hali verilen, 23 maddelik puanlama anahtarının kapsam geçerlik indeksinin 0.91 olduğu belirlendi. Güvenirlik için yapılan analizde, iki gözlemci arasındaki puanlara ilişkin Kappa değerinin 0.84 (p=0.001) ve sınıf içi korelasyon katsayısının 0.98 olduğu belirlendi. Ölçeğin 15 gün sonra yapılan test-tekrar test analizinde, ikinci uygulamada puanların anlamlı bir şekilde yükseldiği görüldü. Her iki ölçüm arasında istatiksel olarak anlamlı farklılık olduğu belirlendi (p
The Active Fraction of Massive Black Holes in Dwarf Galaxies
Authors: Pacucci Fabio , Mezcua Mar , Regan John A. 
Published: October 2021

Abstract
The population of massive black holes (MBHs) in dwarf galaxies is elusive, but fundamentally important to understand the coevolution of black holes with their hosts and the formation of the first collapsed objects in the universe. While some progress was made in determining the X-ray detected fraction of MBHs in dwarfs, with typical values ranging from 0%–6%, their overall active fraction,



, is still largely unconstrained. Here, we develop a theoretical model to predict the multiwavelength active fraction of MBHs in dwarf galaxies starting from first principles and based on the physical properties of the host, namely, its stellar mass and angular momentum content. We find multiwavelength active fractions for MBHs, accreting at typically low rates, ranging from 5%–22%, and increasing with the stellar mass of the host as



∼

log
10

M
⋆

4.5

. If dwarfs are characterized by low-metallicity environments, the active fraction may reach ∼30% for the most massive hosts. For galaxies with stellar mass in the range of 107 < M
⋆[ M
⊙] < 1010, our predictions are in agreement with occupation fractions derived from simulations and semi-analytical models. Additionally, we provide a fitting formula to predict the probability of finding an active MBH in a dwarf galaxy from observationally derived data. This model will be instrumental to guide future observational efforts to find MBHs in dwarfs. The James Webb Space Telescope, in particular, will play a crucial role in detecting MBHs in dwarfs, possibly uncovering active fractions ∼3 times larger than current X-ray surveys.
Quantifying Variability of Young Stellar Objects in the Mid-infrared Over 6 Years with the Near-Earth Object Wide-field Infrared Survey Explorer
Authors: Park Wooseok , Lee Jeong-Eun , Contreras Peña Carlos , Johnstone Doug , Herczeg Gregory , Lee Sieun , Lee Seonjae , Bhardwaj Anupam , Moriarty-Schieven Gerald H. 
Published: October 2021

Abstract
Variability in young stellar objects (YSOs) can be caused by various time-dependent phenomena associated with star formation, including accretion rates, geometric changes in the circumstellar disks, stochastic hydromagnetic interactions between stellar surfaces and inner-disk edges, reconnections within the stellar magnetosphere, and hot/cold spots on stellar surfaces. We uncover and characterize ∼1700 variables from a sample of ∼5400 YSOs in nearby low-mass star-forming regions using mid-IR light curves obtained from the 6.5 yr Near-Earth Object Wide-field Infrared Survey Explorer All Sky Survey. The mid-IR variability traces a wide range of dynamical, physical, and geometrical phenomenon. We classify six types of YSO mid-IR variability based on their light curves: secular variability (linear, curved, and periodic) and stochastic variability (burst, drop, and irregular). YSOs in earlier evolutionary stages have higher fractions of variables and higher amplitudes for the variability, with the recurrence timescale of FUor-type outbursts (defined here as ΔW1 or ΔW2 > 1 mag followed by inspection of candidates) of ∼1000 yr in the early embedded protostellar phase. Known eruptive young stars and subluminous objects show fractions of variables similar to the fraction (∼55%) found in typical protostars, suggesting that these two distinct types are not distinct in variability over the 6.5 yr timescale. Along with brightness variability, we also find a diverse range of secular color variations, which can be attributed to a competitive interplay between the variable accretion luminosity of the central source and the variable extinction by material associated with the accretion process.
Integrated Photometry of Multiple Stellar Populations in Globular Clusters
Authors: Jang S. , Milone A. P. , Lagioia E. P. , Tailo M. , Carlos M. , Dondoglio E. , Martorano M. , Mohandasan A. , Marino A. F. , Cordoni G. , Lee Y.-W. 
Published: October 2021

Abstract
Evidence that multiple populations (MPs) are common properties of globular clusters (GCs) has accumulated over the past decades from clusters in the Milky Way and in its satellites. This finding has revived research into GCs, and suggested that their formation at high redshift must have been a much more complex phenomenon than imagined before. However, most information on MPs is limited to nearby GCs. The main limitation is that most studies of MPs rely on resolved stars, posing a major challenge to the investigation of the MP phenomenon in distant galaxies. Here we search for integrated colors of old GCs that are sensitive to the MP phenomenon. To do this, we exploit integrated magnitudes of simulated GCs with MPs, and multiband Hubble Space Telescope photometry of 56 Galactic GCs, where MPs are widely studied, and characterized as part of the UV Legacy Survey of Galactic GCs. We find that both integrated C
F275W,F336W,F438W and m
F275W − m
F814W colors strongly correlate with the iron abundance of the host GC. To second order, the pseudo two-color diagram built with these integrated colors is sensitive to the MP phenomenon. In particular, once the dependence on cluster metallicity is removed, the color residuals depend on the maximum internal helium variation within GCs and on the fraction of second-generation stars. This diagram, which we define here for Galactic GCs, has the potential to detect and characterize MPs from integrated photometry of old GCs, thus providing the possibility to extend their investigation outside the Local Group.
Empirically Determining Substellar Cloud Compositions in the Era of the James Webb Space Telescope
Authors: Luna Jessica L. , Morley Caroline V. 
Published: October 2021

Abstract
Most brown dwarfs have atmospheres with temperatures cold enough to form clouds. A variety of materials likely condense, including refractory metal oxides and silicates; the precise compositions and crystal structures of predicted cloud particles depend on the modeling framework used and have not yet been empirically constrained. Spitzer has shown tentative evidence of the silicate feature in L dwarf spectra and the James Webb Space Telescope (JWST) can measure these features in many L dwarfs. Here, we present new models to predict the signatures of the strongest cloud absorption features. We investigate different cloud mineral species and determine how particle size, mineralogy, and crystalline structure change spectral features. We find that silicate and refractory clouds have a strong cloud absorption feature for small particle sizes (≤1 μm). Model spectra are compared to five brown dwarfs that show evidence of the silicate feature; models that include small particles in the upper layers of the atmosphere produce a broad cloud mineral feature, and that better match the observed spectra than the Ackerman & Marley cloud model. We simulate observations with the Mid-Infrared Instrument (MIRI) instrument on JWST for a range of nearby, cloudy brown dwarfs, demonstrating that these features could be readily detectable if small particles are present. Furthermore, for photometrically variable brown dwarfs, our predictions suggest that with JWST, by measuring spectroscopic variability inside and outside a mineral feature, we can establish silicate (or other) clouds as the cause of variability. Mid-infrared spectroscopy is a promising tool to empirically constrain the complex cloud condensation sequence in brown dwarf atmospheres.
Photometry and Kinematics of Self-gravitating Eccentric Nuclear Disks
Authors: Wernke Heather N. , Madigan Ann-Marie 
Published: October 2021

Abstract
The Andromeda galaxy hosts an elongated nucleus with (at least) two distinct brightness peaks. The double nucleus can be explained by the projection of a thick, apsidally aligned eccentric nuclear disk of stars in orbit about the central black hole. Several nearby early-type galaxies have similar asymmetric nuclear features, indicating the possible presence of eccentric nuclear disks. We create simulated photometric (surface density) and kinematic (line-of-sight velocity) maps of eccentric nuclear disks using N-body simulations. We image our simulations from various lines of sight in order to classify them as double nuclei, offset nuclei, and centered nuclei. We explore the effects of mass segregation on the photometric maps, finding that heavier stars are concentrated in the brighter peak. The average line-of-sight velocity values are lower in an eccentric nuclear disk than for a circular ring about the supermassive black hole. The velocity dispersion values are higher and peak at the position of the supermassive black hole, which does not typically match the peak in photometry.
La Recherche et l’Innovation en France
Authors: Edquist Charles , Zabala-Iturriagagoitia Jon Mikel 
Published: October 2021

Ce chapitre porte sur la commande publique pour l’innovation, décrite comme une « politique de la demande », méritant d’être incluse dans la boîte à outils des dispositifs de soutien à l’innovation, et susceptible d’être utilisée pour répondre à de grands défis. Est déterminé ce qui relève, et ce qui ne relève pas, de la commande publique pour l’innovation. Après avoir défini le concept de commande publique pour l’innovation, nous proposons une typologie selon trois dimensions : l’identité de l’utilisateur du bien ainsi acquis ; les caractéristiques du processus d’achat ; et la nature collaborative ou non de ce processus. Par ailleurs, nous présentons les principales étapes du processus de commande publique pour l’innovation et les illustrons par quatre études de cas, afin de démontrer qu’elle permet de répondre à des besoins humains jusqu’ici non satisfaits et d’apporter des solutions à des problèmes de société.