bluuebunny/crossref_metadata_2025_split huggingface dataset:
FORECASTING THE GROUNDWATER TREATMENT PROCESS IN A BIOREACTOR USING FERROBACTERIA
Authors: Kvartenko Oleksandr , Prysiazhniuk Igor 
Published: December 2021

The monitoring of water quality parameters in 90 settlements of eight regions of Ukraine made it possible to state that groundwater is a complex multicomponent system. Existing deironing stations using simplified aeration-filtration technology are not able to remove Fe (II) compounds from water in the presence of humic complexes. Therefore, in modern conditions, the urgent task is to intensify their work through the introduction of new technologies, including biotechnology with the development of appropriate mathematical models. It is shown that much less attention was paid to modeling the kinetics of groundwater treatment processes in bioreactors than to traditional physicochemical methods, for which modern mathematical models were developed.
The aim of the work is to develop a mathematical model of the kinetics of the process of groundwater treatment in bioreactors. The mathematical model is represented by the Cauchy problem for a nonlinear system of differential equations in partial derivatives of the first order. The system of the Cauchy problem consists of five equations with five unknown functions, which describe the distribution the concentration of ferrum cations, bacteria and the matrix structures in two phases (movable and immobilized) both in space and time. The inverse influence of the characteristics of the process, in particular, the concentration of matrix structures in the inter-pore space, as well as characteristics of the medium with the help of coefficients of mass exchange and porosity, were taken into account. The model allows determining the optimum operation time of a bioreactor between washings
FERRITATIVE WASTEWATER TREATMENT FROM CHROMIUM (VI) COMPOUNDS USING ELECTROMAGNETIC PULSE ACTIVATION
Authors: Pakhomov Dmitry , Kochetov Gennadii , Samchenko Dmitry 
Published: December 2021

Issues related to the prospects of implementing the latest technologies aimed at achieving energy efficiency in the field of water supply, resource conservation in material-intensive processes at industrial enterprises and prevention of environmental pollution are considered. A study of ferritative wastewater treatment from chromium compounds, which belong to the first class of danger. The efficiency of thermal and electromagnetic pulse activation of the process is compared. Appropriate experimental setups were developed and the main parameters of the purification process were studied and determined: the ratio of iron (II) and chromium (VI) ions, magnetic field strength, frequency of electromagnetic pulses, ferritization process duration, temperature and pH of the reaction mixture.
The expediency of using electromagnetic pulse activation of the reaction mixture by passing electromagnetic pulses through the reaction mixture has been studied and scientifically substantiated. Rational values ​​of the strength and frequency of the electromagnetic field when using this method of activation, which are 0.01 - 0.14 Tl and 1 Hz, respectively, as well as the ratio of concentrations of heavy metal ions Fe2 + / Cr6 + = 10/1 for washing water chrome plating line . It is shown that purified water meets the requirements of category 1 when reused in production. The results of X-ray diffraction analysis of ferritization sediments showed that stable crystalline phases, such as chromium ferrites and magnetite, are formed with increasing magnetic field strength. The chemical resistance of sludge allows them to be safely disposed of. It is established that this method of electromagnetic pulse activation is not inferior to thermal, and the technical and economic calculations confirmed a significant reduction in industrial costs in its application
O MITO DE AFRODITE EM CONTRAPONTO AO MITO DA BELEZA NA CONTEMPORANEIDADE
Authors: Viana Adriano Carvalho , Cirino Marta 
Published: December 2021

<span>O texto analisa o mito da deusa Afrodite e seus desdobramentos na mitologia grega, a <span>importância da beleza no viés físico e platônico. Noutro ponto, verifica-se a desmistificação do ideal de <span>beleza, uma beleza mutável, ditada pela mídia, esse estereótipo culmina em um mercado ilusório e <span>distorcido, porque a beleza ideal é ideal porque não existe, além de acompanhar alguns aspectos sociais <span>e de repercussão pertinente. A partir de uma metodologia bibliográfica, objetivou-se correlacionar o tema <span>beleza a partir de leituras filosóficas, feminista e médica (estética), de modo a propor uma reflexão à <span>sociedade, em especial às mulheres, para que tenham ciência do fenômeno beleza.</span></span></span></span></span></span><br /><br class="Apple-interchange-newline" /></span>
Covid-19 y circuitos cortos de comercialización de alimentos en Argentina: El papel de los actores sociales
Authors: Craviotti Clara , Viteri María Laura , Quinteros Gladys 
Published: December 2021

Abstract: Covid-19 and short food supply circuits in Argentina: The role of social actorsThe aim of this article is to analyze how the actors participating in short food supply circuits reconstructed their practices in the context of the pandemic in Argentina. Based on the analysis of experiences in different geographical areas, heterogeneous processes were identified. This diversity is related to agroecological characteristics, population density, and the level of resources of producers and consumers, among other factors. The pandemic has increased the sales based on geographical proximity in several of the cases analyzed; in others, particularly those linked to tourism, it led to the search of alternatives based on new networks and/or the strengthening of previous ones, using virtual connections that were enhanced in the situation studied. This reconfiguration is associated with a redefinition of the actors involved in short food supply circuits, especially the strengthening of hybrid intermediaries. ResumenEl objetivo del artículo es analizar cómo los actores participantes de los circuitos cortos de comercialización de alimentos reconstruyeron sus prácticas en el contexto de la pandemia en la Argentina. A partir del análisis de experiencias relevadas en diferentes áreas geográficas, se identificaron procesos heterogéneos vinculados, entre otros factores, con características agroecológicas, densidad poblacional y el nivel de recursos de productores y consumidores. La pandemia acentuó las ventas basadas en la proximidad geográfica en varios de los casos analizados; en otros, particularmente los ligados al turismo, condujo a la búsqueda de alternativas a partir de nuevos vínculos y/o el reforzamiento de previos, apelando a conexiones virtuales que se potenciaron en la coyuntura estudiada. Esta reconfiguración está conectada con una redefinición de los actores participantes en circuitos cortos de comercialización, en particular la consolidación de intermediarios híbridos.
Lipoic Acid Does Not Affect The Growth of Mycoplasma hominis Cells In Vitro
Authors: BIERNAT-SUDOLSKA MAŁGORZATA , ROJEK-ZAKRZEWSKA DANUTA , GAJDA PAULINA , BILSKA-WILKOSZ ANNA 
Published: December 2021

Abstract

Mycoplasma hominis is associated with various infections, for which the treatment can be complex. Lipoic acid (LA) plays a role as a cofactor in eukaryotes, most Bacteria, and some Archea. Research of recent years has increasingly pointed to the therapeutic properties of exogenously supplemented LA. The present study was conducted on 40 strains of M. hominis cultured with the following LA concentrations: 1,200 μg/ml, 120 μg/ml, and 12 μg/ml. The bacterial colonies of each strain were counted and expressed as the number of colony-forming units/ml (CFU). The number of CFU in M. hominis strains obtained in the presence of LA was compared with the number of CFU in the strains grown in the media without LA. The obtained results indicated that the presence of LA in the medium did not affect the growth of M. hominis. The investigation of the influence of LA on the growth and survival of microbial cells not only allows for obtaining an answer to the question of whether LA has antimicrobial activity and, therefore, can be used as a drug supporting the treatment of patients infected with a given pathogenic microorganism. Such studies are also crucial for a better understanding of LA metabolism in the microbial cells, which is also important for the search for new antimicrobial drugs. This research is, therefore, an introduction to such further studies.
Метод підвищення надійності програмного забезпечення знання-орієнтованих систем за рахунок механізмів повторного використання коду
Authors: Костюк Ігор , Павленко Максим , Осієвський Сергій , Несміян Олексій 
Published: December 2021

Розглянуті питання можливості застосування механізму повторного використання коду в процесі проектування та розробки програмного забезпечення знання-орієнтованих систем. Доведена необхідність окремого дослідження питань розробки програмного забезпечення аналітичного та інформаційного ресурсів, що забезпечують підтримку всіх учасників процесу розробки програмного забезпечення знання-орієнтованих систем. Показана необхідність використання механізмів повторного використання раніше розробленого і верифікованого програмного коду, як елементу інформаційного ресурсу. В рамках розробленого методу підвищення надійності програмного забезпечення знання-орієнтованих систем за рахунок механізмів повторного використання коду запропонована нова візуальна форма подання бібліотек функцій у вигляді єдиної програмної оболонки. В якості базового інструментарію вирішення завдання розробки інформаційного ресурсу запропоновано використовувати UML (Unified Modeling Language) – уніфіковану мову моделювання, в основу якої покладено парадигму об'єктно-орієнтованого програмування. Зазначений вибір обґрунтований тим, що UML є невід'ємною частиною уніфікованого процесу розробки програмного забезпечення та по суті являється відкритим стандартом, що використовує графічні позначення для створення абстрактної моделі системи. Отримані теоретичні положення відображені в наскрізному прикладі, що відображає однин з можливих варіантів організації бібліотек функцій як елементу інформаційного ресурсу. Розроблено та обґрунтовано діаграми варіантів використання, діаграми взаємодії, діаграми послідовності, діаграми класів. На основі отриманих практичних результатів запропоновано структурну схему методу, яка, на відміну від існуючих рішень включає процедуру вироблення коректур для основних UML-діаграм за вимогами середовищ програмування.
A 3-D Finite-Element Minipig Model to Assess Brain Biomechanical Responses to Blast Exposure
Authors: Sundaramurthy Aravind , Kote Vivek Bhaskar , Pearson Noah , Boiczyk Gregory M. , McNeil Elizabeth M. , Nelson Allison J. , Subramaniam Dhananjay Radhakrishnan , Rubio Jose E. , Monson Kenneth , Hardy Warren N. , VandeVord Pamela J. , Unnikrishnan Ginu , Reifman Jaques 
Published: December 2021

Despite years of research, it is still unknown whether the interaction of explosion-induced blast waves with the head causes injury to the human brain. One way to fill this gap is to use animal models to establish “scaling laws” that project observed brain injuries in animals to humans. This requires laboratory experiments and high-fidelity mathematical models of the animal head to establish correlates between experimentally observed blast-induced brain injuries and model-predicted biomechanical responses. To this end, we performed laboratory experiments on Göttingen minipigs to develop and validate a three-dimensional (3-D) high-fidelity finite-element (FE) model of the minipig head. First, we performed laboratory experiments on Göttingen minipigs to obtain the geometry of the cerebral vasculature network and to characterize brain-tissue and vasculature material properties in response to high strain rates typical of blast exposures. Next, we used the detailed cerebral vasculature information and species-specific brain tissue and vasculature material properties to develop the 3-D high-fidelity FE model of the minipig head. Then, to validate the model predictions, we performed laboratory shock-tube experiments, where we exposed Göttingen minipigs to a blast overpressure of 210 kPa in a laboratory shock tube and compared brain pressures at two locations. We observed a good agreement between the model-predicted pressures and the experimental measurements, with differences in maximum pressure of less than 6%. Finally, to evaluate the influence of the cerebral vascular network on the biomechanical predictions, we performed simulations where we compared results of FE models with and without the vasculature. As expected, incorporation of the vasculature decreased brain strain but did not affect the predictions of brain pressure. However, we observed that inclusion of the cerebral vasculature in the model changed the strain distribution by as much as 100% in regions near the interface between the vasculature and the brain tissue, suggesting that the vasculature does not merely decrease the strain but causes drastic redistributions. This work will help establish correlates between observed brain injuries and predicted biomechanical responses in minipigs and facilitate the creation of scaling laws to infer potential injuries in the human brain due to exposure to blast waves.
A New Biomarker of Fecal Bacteria for Non-Invasive Diagnosis of Colorectal Cancer
Authors: Yao Yizhou , Ni Haishun , Wang Xuchao , Xu Qixuan , Zhang Jiawen , Jiang Linhua , Wang Bin , Song Shiduo , Zhu Xinguo 
Published: December 2021

BackgroundThe intestinal flora is correlated with the occurrence of colorectal cancer. We evaluate a new predictive model for the non-invasive diagnosis of colorectal cancer based on intestinal flora to verify the clinical application prospects of the intestinal flora as a new biomarker in non-invasive screening of colorectal cancer.MethodsSubjects from two independent Asian cohorts (cohort I, consisting of 206 colorectal cancer and 112 healthy subjects; cohort II, consisting of 67 colorectal cancer and 54 healthy subjects) were included. A probe-based duplex quantitative PCR (qPCR) determination was established for the quantitative determination of candidate bacterial markers.ResultsWe screened through the gutMEGA database to identify potential non-invasive biomarkers for colorectal cancer, including Prevotella copri (Pc), Gemella morbillorum (Gm), Parvimonas micra (Pm), Cetobacterium somerae (Cs), and Pasteurella stomatis (Ps). A predictive model with good sensitivity and specificity was established as a new diagnostic tool for colorectal cancer. Under the best cutoff value that maximizes the sum of sensitivity and specificity, Gm and Pm had better specificity and sensitivity than other target bacteria. The combined detection model of five kinds of bacteria showed better diagnostic ability than Gm or Pm alone (AUC = 0.861, P &lt; 0.001). These findings were further confirmed in the independent cohort II. Particularly, the combination of bacterial markers and fecal immunochemical test (FIT) improved the diagnostic ability of the five bacteria (sensitivity 67.96%, specificity 89.29%) for patients with colorectal cancer.ConclusionFecal-based colorectal cancer-related bacteria can be used as new non-invasive diagnostic biomarkers of colorectal cancer. Simultaneously, the molecular biomarkers in fecal samples are similar to FIT, have the applicability in combination with other detection methods, which is expected to improve the sensitivity of diagnosis for colorectal cancer, and have a promising prospect of clinical application.
Utility of S100A12 as an Early Biomarker in Patients With ST-Segment Elevation Myocardial Infarction
Authors: Zhang Xiaolin , Cheng Minghui , Gao Naijing , Li Yi , Yan Chenghui , Tian Xiaoxiang , Liu Dan , Qiu Miaohan , Wang Xiaozeng , Luan Bo , Deng Jie , Wang Shouli , Tian Hongyan , Wang Geng , Ma Xinliang , Stone Gregg W. , Han Yaling 
Published: December 2021

Importance: S100A12 is a calcium binding protein which is involved in inflammation and progression of atherosclerosis.Objective: We sought to investigate the utility of S100A12 as a biomarker for the early diagnosis and prognostication of patients presenting with ST-segment elevation myocardial infarction (STEMI).Design, Setting, and Participants: S100A12 was measured in 1023 patients presenting to the emergency department with acute chest pain between June 2012 and November 2015. An independent cohort of 398 patients enrolled at 3 different hospitals served as a validation cohort.Main Outcomes and Measures: The primary clinical endpoint of interest was major adverse cardiac and cerebral events (MACCE) defined as a composite of all-cause death, MI, stroke, or hospitalization for heart failure.Results: A total of 438/1023 patients (42.8%) in the diagnosis cohort were adjudicated as STEMI, among whom plasma S100A12 levels increased within 30 min and peaked 1–2 h after symptom onset. Compared with high-sensitivity cardiac troponin T and creatine kinase-MB isoenzyme, S100A12 more accurately identified STEMI, especially within the first 2 h after symptom onset (area under the curve 0.963 compared with 0.860 for hscTnT and 0.711 for CK-MB, both P &lt; 0.05). These results were consistent in the 243-patient validation cohort. The 1-year rate of MACCE was greatest in patients in the highest peak S100A12 tertile, intermediate in the middle tertile and least in the lowest tertile (9.3 vs. 5.7 vs. 3.0% respectively, Ptrend = 0.0006). By multivariable analysis the peak plasma concentration of S100A12 was an independent predictor of MACCE within 1 year after STEMI (HR, 1.001, 95%CI, 1.000–1.002; P = 0.0104).Conclusions and Relevance: S100A12 rapidly identified patients with STEMI, more accurately than other cardiac biomarkers, especially within the first 2 h after symptom onset. The peak plasma S100A12 level was a strong predictor of 1-year prognosis after STEMI.
Inhibition of Sphingosine-1-Phosphate Receptor 2 Prevents Thoracic Aortic Dissection and Rupture
Authors: Pan Guangwei , Liao Mengyang , Dai Yong , Li Yang , Yan Xiaole , Mai Wuqian , Liu Jinping , Liao Yuhua , Qiu Zhihua , Zhou Zihua 
Published: December 2021

Background: Numerous pieces of evidence have indicated that thoracic aortic dissection (TAD) is an inflammatory disease. Sphingosine-1-phosphate receptor 2 (S1PR2) signaling is a driver in multiple inflammatory diseases. Here, we examined the S1PR2 expression in TAD lesions and explored the effect of interfering with S1PR2 on TAD formation and progression.Methods: Aorta specimens and blood samples were collected from patients with TAD and matched controls. The expression of S1PR1, S1PR2, and S1PR3 was examined. The effect of inhibiting S1PR2 on TAD was evaluated in a TAD mouse model induced by β-aminopropionitrile fumarate (BAPN) and AngII. The presence of sphingosine kinase 1 (SPHK1), S1P, and neutrophil extracellular traps (NETs) was investigated. Further, the possible association between S1PR2 signaling and NETs in TAD was analyzed.Results: In the aortic tissues of patients with TAD and a mouse model, the S1PR2 expression was significantly up-regulated. In the TAD mouse model, JTE013, a specific S1PR2 antagonist, not only blunted the TAD formation and aortic rupture, but also preserved the elastic fiber architecture, reduced the smooth muscle cells apoptosis level, and mitigated the aortic wall inflammation. Augmented tissue protein expression of SPHK1, citrullinated histone H3 (CitH3, a specific marker of NETs), and serum S1P, CitH3 were detected in TAD patients. Surgical repair normalized the serum S1P and CitH3 levels. Immunofluorescence staining revealed that S1PR2 colocalized with NETs. The protein expression levels of SPHK1 and serum S1P levels positively correlated with the protein expression and serum levels of CitH3, separately. Furthermore, JTE013 treatment reduced NETs accumulation.Conclusion: Inhibiting S1PR2 attenuates TAD formation and prevents aortic rupture. Targeting S1PR2 may provide a promising treatment strategy against TAD.
The Impact of Ischemia Assessed by Magnetic Resonance on Functional, Arrhythmic, and Imaging Features of Hypertrophic Cardiomyopathy
Authors: Aguiar Rosa Sílvia , Thomas Boban , Fiarresga António , Papoila Ana Luísa , Alves Marta , Pereira Ricardo , Branco Gonçalo , Cruz Inês , Rio Pedro , Baquero Luis , Ferreira Rui Cruz , Mota Carmo Miguel , Lopes Luís Rocha 
Published: December 2021

Aims: The aim of the study is to investigate the association between the degree of ischemia due to coronary microvascular dysfunction (CMD) and the left ventricular (LV) tissue characteristics, systolic performance, and clinical manifestations in hypertrophic cardiomyopathy (HCM).Methods and Results: This prospective study enrolled 75 patients with HCM without obstructive epicardial coronary artery disease. Each patient underwent cardiovascular magnetic resonance (CMR) including parametric mapping, perfusion imaging during regadenoson-induced hyperemia, late gadolinium enhancement (LGE) and three-dimensional longitudinal, circumferential, and radial strains analysis. Electrocardiogram, 24-h Holter recording, and cardiopulmonary exercise testing (CPET) were performed to assess arrhythmias and functional capacity. In total, 47 (63%) patients were men with the mean age of 54.6 (14.8) years, 51 (68%) patients had non-obstructive HCM, maximum wall thickness (MWT) was 20.2 (4.6) mm, LV ejection fraction (LVEF) was 71.6 (8.3%), and ischemic burden was 22.5 (16.9%) of LV. Greater MWT was associated with the severity of ischemia (β-estimate:1.353, 95% CI:0.182; 2.523, p = 0.024). Ischemic burden was strongly associated with higher values of native T1 (β-estimate:9.018, 95% CI:4.721; 13.315, p &lt; 0.001). The association between ischemia and LGE was significant in following subgroup analyses: MWT 15–20 mm (β-estimate:1.941, 95% CI:0.738; 3.143, p = 0.002), non-obstructive HCM (β-estimate:1.471, 95% CI:0.258; 2.683, p = 0.019), women (β-estimate:1.957, 95% CI:0.423; 3.492, p = 0.015) and age &lt;40 years (β-estimate:4.874, 95% CI:1.155; 8.594, p = 0.016). Ischemia in ≥21% of LV was associated with LGE &gt;15% (AUC 0.766, sensitivity 0.724, specificity 0.659). Ischemia was also associated with atrial fibrillation or flutter (AF/AFL) (OR-estimate:1.481, 95% CI:1.020; 2.152, p = 0.039), but no association was seen for non-sustained ventricular tachycardia. Ischemia was associated with shorter time to anaerobic threshold (β-estimate: −0.442, 95% CI: −0.860; −0.023, p = 0.039).Conclusion: In HCM, ischemia associates with morphological markers of severity of disease, fibrosis, arrhythmia, and functional capacity.