bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD11b is involved in coxsackievirus B3-induced viral myocarditis in mice by inducing Th17 cells
Authors: Wei Heng , Lin Chong-Kai , Lu Sheng-Jian , Wen Yu-Xin , Yuan Shuai , Liu Yan-Li 
Published: January 2021

AbstractViral myocarditis (VMC) caused by coxsackievirus B3 (CVB3) infection is a life-threatening disease. The cardiac damage during VMC is not mainly due to the direct cytotoxic effect of the virus on cardiomyocytes but mostly involves the induction of immune responses. Integrin CD11b plays an important role in immune response, for instance, in the induction of Th17 cells. However, the role of CD11b in the pathogenesis of VMC remains largely unknown. In the present study, a mouse model of VMC was established by CVB3 infection and CD11b was knocked down in the VMC mice by transfection with siRNA-CD11b. The expression of CD11b and IL-17 in heart tissues, frequency of Th17 cells in spleen tissues and serum IL-17 levels were measured using quantitative RT-PCR, Western blot, immunohistochemistry, flow cytometry and ELISA. Results showed that CVB3 infection caused the pathological changes in heart tissues with the increases in the following indexes: expression of CD11b and IL-17 in heart tissues, frequency of Th17 cells in spleen tissues and serum IL-17 levels. The expression of CD11b was positively correlated with IL-17 expression in heart tissues. Depletion of CD11b attenuated the damage caused by CVB3 and decreased the frequency of Th17 cells in spleen tissues as well as in IL-17, IL-23 and STAT3 expression in heart tissues. In summary, our findings reveal that disruption of CD11b function reduced CVB3-induced myocarditis, suggesting that CD11b may be a novel therapeutic target for VMC.
Effects of center pivot sprinkler fertigation on the yield of continuously cropped soybean
Authors: Cao Hua , Fan Yongshen , Chen Zhen , Huang Xiuqiao 
Published: January 2021

AbstractContinuous cropping is a common agricultural practice in Northeast China. Focusing on soybeans cropped continuously for two consecutive years, this article fully explores the effects of the amount of water, fertilizing rate, and fertilizing method on the growth and yield of soybean. Specifically, an orthogonal experimental plan was designed involving these three factors. Each factor was divided into three levels: the amount of water was set as 52.62 mm (W1), 73.41 mm (W2), and 138.6 mm (W3); the fertilizing rate was set as 6.75 kg/hm2 (N1), 9.75 kg/hm2 (N2), and 13.5 kg/hm2 (N3); and the fertilizing method was set as center pivot sprinkler (CPS) fertigation (F1), microspray (MS) fertigation (F2), and MS fertilizing + CPS spraying and leaching (F3). During the experiments, the growth traits at each growth stage were monitored, and the soybean yield was measured. The following results were obtained through the analysis of the experimental data: the amount of water significantly affects the growth traits of soybean in the early stage of growth; the fertilizing rate greatly affects the stem diameter; and the fertilizing method is a major influencer of soybean yield. The highest yield (2811.88 kg/hm2) was observed in zone 4 (W2N1F2). This means irrigation and fertilization are very important to the normal growth of continuously cropped soybean; the yield loss induced by continuous cropping can be mitigated effectively through timely and adequate irrigation and topdressing, plus fertilization by the suitable method. To prevent yield loss, farmers in Northeast China are suggested to replace continuous cropping with crop rotation. If continuous cropping is unavoidable, foliage fertilizer should be sprayed timely for topdressing at the flowering and seed-filling stages.
Decitabine shows anti-acute myeloid leukemia potential via regulating the miR-212-5p/CCNT2 axis
Authors: Xing Lina , Ren Jinhai , Guo Xiaonan , Qiao Shukai , Tian Tian 
Published: January 2021

AbstractPrevious research has revealed the involvement of microRNA-212-5p (miR-212-5p) and cyclin T2 (CCNT2) in acute myeloid leukemia (AML). However, whether the miR-212-5p/CCNT2 axis is required for the function of decitabine in AML has not been well elucidated. Quantitative reverse transcription-polymerase chain reaction was used to examine enrichment of miR-212-5p. The relationship between CCNT2 and miR-212-5p was verified by the luciferase reporter assay. Cell apoptosis was evaluated by flow cytometry and western blot. CCK-8 assay was performed to determine cell viability. Decitabine significantly repressed cell viability, while promoted cell apoptosis. Meanwhile, the expression levels of cyclinD1, CDK4, and Bcl-2 were suppressed in cells with decitabine exposure, but Bax and caspase-3 expression levels were upregulated. Besides, miR-212-5p upregulation had the similar function with decitabine in AML cell proliferation and apoptosis. Subsequently, restoration of CCNT2 attenuated miR-212-5p overexpression-induced effects in Kasumi-1 and SKNO-1 cells. In addition, miR-212-5p depletion reversed decitabine-induced CCNT2 downregulation. The miR-212-5p/CCNT2 axis had an implication in the anti-leukemic effect of decitabine in AML.
Effects of Bacillus megaterium on growth performance, serum biochemical parameters, antioxidant capacity, and immune function in suckling calves
Authors: Yao Jun , Wang Lili , Zhang Wenju , Liu Mengjian , Niu Junli 
Published: January 2021

AbstractBackgroundThis study was conducted to investigate the effects of Bacillus megaterium on growth performance, serum biochemical parameters, antioxidant capacity, and immune function in suckling calves.MethodsIn total, 20 1-day-old Holstein calves with similar body weight (BW) and good health condition were randomly assigned into two groups with ten replicates per group and one calf per replicate. The control group (CON group) was fed a basal diet, whereas the B. megaterium group (BM group) was fed the basal diet supplemented with 500 mg/day/head of B. megaterium (1010 CFU/g) for 28 days.ResultsThe results revealed that the BM group showed an increase in final BW, daily weight gain, and feed-to-gain ratio (p < 0.05) and a decrease in diarrhea rate. Moreover, the concentrations of serum cholesterol and high-density lipoprotein decreased (p < 0.05) in the BM group compared with the CON group at 28 days. The level of serum glutathione was higher (p < 0.05) in the BM group than that of the CON group at 14 days, whereas the level of serum malondialdehyde decreased (p < 0.01) in the BM group compared with the CON group at 28 days. In addition, compared with the CON group (p < 0.05), the concentrations of serum IgA, IgM, IgG, and IL-4 were higher, whereas the concentration of serum TNF-α decreased in the BM group at 28 days.ConclusionB. megaterium had beneficial effects on the improvement of growth performance, immune function, and intestinal oxidative status of suckling calves.
Testosterone aggravates cerebral vascular injury by reducing plasma HDL levels
Authors: Jin Tao , Wang Lu , Li Dongbo , Yang Tao , Zhou Yuefei 
Published: January 2021

AbstractTestosterone is often used to improve the physiological function. But increased testosterone levels affect blood lipids and cause inflammation and oxidative stress, which are risk factors for vascular diseases. This study aimed at investigating the effects of testosterone on cerebral vascular injury using an established intracranial aneurysm (IA) model. Sixteen-week-old female C57Bl/6 mice were subcutaneously infused with testosterone propionate (TP; 5 mg/kg day) or plain soybean oil (controls) for 6 weeks. After 2 weeks of treatment, mice were given angiotensin II-elastase for another 4 weeks. The results showed that TP significantly increased cell apoptosis and reactive oxygen species production in cerebral artery, together with increases in plasma tumor necrosis factor-α (TNF-α) levels and in urinary 8-isoprostane levels. Plasma assays showed that 2 weeks after TP or soybean oil administration, the high-density lipoprotein (HDL) level was higher in the TP group than in controls. In vitro studies showed that testosterone increased TNF-α and monocyte chemotactic protein-1 mRNA and protein expression levels in RAW 264.7 macrophages. In summary, by reducing the HDL level, TP aggravates cerebral artery injury by increasing cell apoptosis, inflammation, and oxidative stress.
Graphene Oxide: A Promising Material for Regenerative Medicine and Tissue Engineering
Authors: Maleki Masomeh , Zarezadeh Reza , Nouri Mohammad , Sadigh Aydin Raei , Pouremamali Farhad , Asemi Zatollah , Kafil Hossein Samadi , Alemi Forough , Yousefi Bahman 
Published: January 2021

AbstractRegenerative medicine and tissue engineering have been considered pioneer fields in the life sciences, with an ultimate goal of restoring or switching lost or impaired body parts. Graphene oxide (GO) is the product of graphene oxidation and presents a great opportunity to make substantial progress in the field of regenerative medicine; for example, it supports the possibility of creating a cellular niche for stem cells on a nanoparticle surface. GO creates a fascinating structure for regulating stem cell behavior, as it can potentially applied to the noninvasive chase of stem cells in vivo, the liberation of active biological factors from stem cell-containing delivery systems, and the intracellular delivery of factors such as growth factors, DNA, or synthetic proteins in order to modulate stem cell differentiation and proliferation. Due to the interesting physicochemical properties of GO and its possible usage in tissue engineering approaches, the present review aims to elaborate on the ways in which GO can improve current regenerative strategies. In this respect, the applicability of GO to the repair and regeneration of various tissues and organs, including cardiac muscle, skeletal muscle, and nervous, bone, cartilage, adipose, and skin tissues, is discussed.
Dysregulation of epigenetic related genes in Diabetic Trigger finger Patients; preliminary analysis of Patient-Derived Samples
Authors: Cain Michael , Awad Mohamed E. , Kolhe Ravindra , Mondal Ashis K. , Ghilzai Umar , Isales Carlos , Fulcher Mark , Fulzele Sadanand 
Published: January 2021

AbstractBackgroundTrigger finger (TF), a painful condition involving a finger flexor tendon, is a common problem with a prevalence of ~2-3% in the general population. However, the TF prevalence is higher among diabetic patients-ranges from 6.7% to 10%. We have analyzed the expression of the extracellular matrix, inflammation, and epigenetic related genes in diabetic and non-diabetes TF. We hypothesized that Diabetes condition induces alter the expression of epigenetic modification genes in diabetic patients and one of the underlying determinants for more prevalence of TF in diabetic patients.MethodTissues from the fingers of patients with symptomatic trigger fingers were collected. We had three groups: carpal tunnel syndrome (as a control), trigger finger, and diabetic trigger finger. A quantitative real-time polymerase chain reaction was performed. The gene expression of Extracellular matrix (ECM) components [COL-I, COL-II, COL-X, Aggrecan], DNA methyltransferases enzymes (DNMT1, DNMT3), growth factors (TGF-b, IGF), and Histone deacetylase enzymes (HDAC1, HDAC2) were evaluated in all groups.ResultsThe mRNA expression of COL-I, COL-II, Aggrecan was significantly higher in the pully A1 of diabetic patients (p= 0.0164, p=0.0351, p=0.0399, respectively) as compared to non-diabetic TF patients. Diabetes was associated with a significant increase in the DNMT3 expression compared to non-diabetic TF patients (p=0.0485). HDAC1 and HDAC2 gene expression were up-regulated in diabetic TF than non-diabetic TF.ConclusionThe chronic state of hyperglycemia induces epigenetic modification of gene expressions in trigger fingers. This seems to have a significant impact on the development, recurrence, and progression of trigger finger in diabetic patients.
Effectiveness of removal of sulphur compounds from the air after 3 years of biofiltration with a mixture of compost soil, peat, coconut fibre and oak bark
Authors: Chmielowiec-Korzeniowska Anna , Tymczyna Leszek , Nowakowicz-Dębek Bożena , Dobrowolska Magdalena 
Published: January 2021

AbstractThe aim of the study was to assess the impact of the duration of the use of a biofiltration bed on the efficiency of biofiltration of sulphur compounds and on the physicochemical and microbiological properties of the bed. The study was carried out at an animal waste treatment plant. Two biofiltration chambers (beds A and B) filled with different organic mixtures (compost soil, peat, coconut fibre and oak bark) were used in the biofilter. Chromatographic analysis showed a very high rate of effectiveness in the first study period, irrespective of the packaging material used. The best effects were obtained for inorganic sulphur compounds (above 99%). The duration of use of the bed material was shown to affect the efficiency of biofiltration. After 3 years of operation, thiol degradation efficiency fell below 50%. The biological decomposition of inorganic compounds (H2S + SO2) was 73% and 59.6% in beds A and B, respectively. Analysis of the biofiltration material indicated stabilization of its physicochemical parameters. Numbers of bacteria were not found to be depend on the duration of use or the type of filtering media.
Synthesis and Activity of New Schiff Bases of Furocoumarin
Authors: Xie Huijun , Niu Chao , Chao Zeyang , Mamat Nuramina , Akber Aisa Haji 
Published: January 2021

Abstract
Furocoumarins, such as 8-MOP, are the most common medications used to relieve the symptoms of vitiligo clinically. Some furocoumarins also showed excellent performance in an anti-bacterial assay. This paper describes the synthesis of a series of novel Schiff bases (6a-6k), and their promotion in melanogenesis and anti-bacterial properties were studied in vitro.
The pigment production of B16 cells and bacterial inhibition ring assay were applied for the bioactivity of 6a-6k. According to the results, a stronger promotion on pigment content was observed, when six compounds co-cultured with cells, compared with positive control (8-MOP). Significantly, compound 6k (237%) as the most active was found to increase the amount of melanin more than 1.7 times compared with 8-MOP activation rate (136%). All the compounds could moderately retard C. albicans growth. Interestingly, aldehyde 5, which possessed a broader antibacterial spectrum, showed the highest inhibition against C. albicans as well and much better than the positive control (Amphotericin B).
Studies of 6k in animal models of vitiligo and related molecular mechanism are presently under way, with the aim of discovering an anti-vitiligo leading compound.
Estimating Average Treatment Effects Utilizing Fractional Imputation when Confounders are Subject to Missingness
Authors: Corder Nathan , Yang Shu 
Published: January 2021

Abstract
The problem of missingness in observational data is ubiquitous. When the confounders are missing at random, multiple imputation is commonly used; however, the method requires congeniality conditions for valid inferences, which may not be satisfied when estimating average causal treatment effects. Alternatively, fractional imputation, proposed by Kim 2011, has been implemented to handling missing values in regression context. In this article, we develop fractional imputation methods for estimating the average treatment effects with confounders missing at random. We show that the fractional imputation estimator of the average treatment effect is asymptotically normal, which permits a consistent variance estimate. Via simulation study, we compare fractional imputation’s accuracy and precision with that of multiple imputation.
Effect of rice husk (treated/untreated) and rice husk ash on fracture toughness of epoxy bio-composite
Authors: Bisht Neeraj , Chandra Gope Prakash 
Published: January 2021

AbstractPresent work studies the effect of particle reinforcement on fracture toughness of bio-composites. The filler used has been taken as rice husk. Epoxy resin has been taken as matrix material. Composites with varying filler loading of 10, 20, 30 and 40 wt.% were fabricated. The fracture toughness was seen to be increasing with increase in filler loading. However beyond 20% there was a decrease in fracture toughness with increase in filler loading. The effect of fibre treatment on toughness was also observed. Rice husk fibres pre-treated with NaOH were used. It was observed that fracture toughness further improved due to treatment. The increase in fracture toughness was significant. Fracture toughness increased from 1.072 to 2.7465 MPa√mm for 20% reinforcement and after treatment it increased to 2.876 MPa√mm. It was observed that concentration of treatment media also affects the fracture toughness. Further the effect of hybridization was observed by addition of rice husk ash as a secondary reinforcement. The fracture toughness of the resulting composites was remarkably higher than that of pure epoxy.
A new characterization of a proper type B semigroup
Authors: Li Chunhua , Pei Zhi , Xu Baogen 
Published: January 2021

Abstract
In this paper, we develop the elementary theory of inverse semigroups to the cases of type B semigroups. The main aim of this paper is to study proper type B semigroups. We introduce first the concept of a left admissible triple. After obtaining some basic properties of left admissible triple, we give the definition of a Q-semigroup and get a structure theorem of Q-semigroup. In particular, we introduce the notion of an admissible triple and give some characterization of proper type B semigroups. It is proved that an arbitrary Q-semigroup with an admissible triple is an E-unitary type B semigroup.
A modified Tikhonov regularization method based on Hermite expansion for solving the Cauchy problem of the Laplace equation
Authors: Zhao Zhenyu , You Lei , Meng Zehong 
Published: January 2021

Abstract
In this paper, a Cauchy problem for the Laplace equation is considered. We develop a modified Tikhonov regularization method based on Hermite expansion to deal with the ill posed-ness of the problem. The regularization parameter is determined by a discrepancy principle. For various smoothness conditions, the solution process of the method is uniform and the convergence rate can be obtained self-adaptively. Numerical tests are also carried out to verify the effectiveness of the method.
The limit Riemann solutions to nonisentropic Chaplygin Euler equations
Authors: Lin Maozhou , Guo Lihui 
Published: January 2021

Abstract
We mainly consider the limit behaviors of the Riemann solutions to Chaplygin Euler equations for nonisentropic fluids. The formation of delta shock wave and the appearance of vacuum state are found as parameter

ε

\varepsilon

tends to a certain value. Different from the isentropic fluids, the weight of delta shock wave is determined by variance density

ρ

\rho

and internal energy H. Meanwhile, involving the entropy inequality, the uniqueness of delta shock wave is obtained.
The edge-regular complete maps
Authors: Yu Xue , Lou Ben Gong 
Published: January 2021

Abstract
A map is called edge-regular if it is edge-transitive but not arc-transitive. In this paper, we show that a complete graph

K

n

{K}_{n}

has an orientable edge-regular embedding if and only if

n
=

p

d

>
3

n={p}^{d}\gt 3

with p an odd prime such that

p

d

≡
3

{p}^{d}\equiv 3

(
mod

4
)

(\mathrm{mod}\hspace{.25em}4)

. Furthermore,

K

p

d

{K}_{{p}^{d}}

has

p

d

−
3

4
d

ϕ
(

p

d

−
1

2

)

\tfrac{{p}^{d}-3}{4d}\hspace{0.25em}\phi \left(\tfrac{{p}^{d}-1}{2}\right)

non-isomorphic orientable edge-regular embeddings.
Estimates of entropy numbers in probabilistic setting
Authors: Han Yongjie , Xiao Hanyue , Chen Guanggui 
Published: January 2021

Abstract
In this paper, we define the entropy number in probabilistic setting and determine the exact order of entropy number of finite-dimensional space in probabilistic setting. Moreover, we also estimate the sharp order of entropy number of univariate Sobolev space in probabilistic setting by discretization method.
Three classes of decomposable distributions
Authors: Jedidi Wissem , Basalim Kholoud , Bridaa Safa 
Published: January 2021

Abstract
In this work, we refine the results of Sendov and Shan [New representation theorems for completely monotone and Bernstein functions with convexity properties on their measures, J. Theor. Probab. 28 (2015), 1689–1725] on subordinators obtained by the class of Bernstein functions stable by the Mellin-Euler differential operator

I
−
x

d

d
x

I-x\tfrac{\text{d}}{\text{d}x}

by giving a stochastic interpretation, proving monotonicity properties of the related distributions and providing additional extensions.
Finite groups with some weakly pronormal subgroups
Authors: Liu Jianjun , Jiang Mengling , Chen Guiyun 
Published: January 2021

AbstractA subgroupHof a finite groupGis called weakly pronormal inGif there exists a subgroupKofGsuch thatG=HKG=HKandH∩KH\cap Kis pronormal inG. In this paper, we investigate the structure of the finite groups in which some subgroups are weakly pronormal. Our results improve and generalize many known results.
Mathematical and numerical optimality of non-singular fractional approaches on free and forced linear oscillator
Authors: Ali Abro Kashif , Qureshi Sania , Atangana Abdon 
Published: January 2021

AbstractThe prediction of oscillators is usually employed in various industrial and technological problems; such as car shock absorbers, bungee jumping, earthquake-proof buildings, musical instruments, metronome and the process of hearing. This manuscript investigates the effects of newly presented fractional operators on free and forced linear oscillators. The second order nonlinear classical governing differential equation of Duffing oscillator is reduced into second order linear classical governing differential equation of free and forced linear oscillators by invoking non-integer order differential operators namely Atangana-Baleanu and Caputo-Fabrizio. The fractionalized differential equation is solved by invoking Laplace transform method for finding the optimal solutions of displacement based on infinite series approach. The solutions of displacement are obtained via Atangana-Baleanu and Caputo-Fabrizio differential operators separately then expressed in terms of elementary and gamma functions. Finally the parametric analysis is depicted graphically on the basis of comparison of modern fractional operators subject to the emerging rheological parameters.