bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obsessive-compulsive symptoms in young women affected with anorexia nervosa and their relationship with personality, psychopathology and attachment style
Authors: Amianto Federico , Arletti Luca , Davico Chiara , Secci Ilaria , Vitiello Benedetto 
Published: April 2021

Abstract
Purpose
Obsessive-compulsive symptoms (OC) are associated with greater morbidity and worse prognosis in anorexia nervosa (AN). We assessed the presence of non-eating OC in participants with AN and related them with their psychopathology, personality, and attachment style features.
Methods
Young women with AN (N = 41, 30 restricter and 11 binge-purging type) were assessed on the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Participants with AN and 82 healthy controls (HC) completed the Temperament and Character Inventory (TCI), Eating Disorder Inventory-2 (EDI-2), Symptom Checklist-90 (SCL- 90), Toronto Alexithymia Scale (TAS-20), and Attachment Style Questionnaire (ASQ), and were compared to underscore the AN features. Y-BOCS scores were correlated to psychopathology, personality, and attachment features in AN participants.
Results
AN had significantly higher scores than HC on EDI-2, SCL-90, TAS-20, ASQ-Need for Approval, and TCI-Harm Avoidance and Self-directedness. The Y-BOCS scores were significantly correlated with ASQ-Need for Approval, TAS-20-Difficulty in Describing Feelings, SCL-90-Phobic Anxiety, and Anxiety, EDI-2-Drive to Thinness and Asceticism. Need for Approval displayed the strongest and broadest correlation pattern with OC symptoms. Difficulty in describing feelings displayed the strongest correlation with compulsive OC symptoms.
Conclusions
OC traits in participants with AN are primarily associated with measures of insecure attachment rather than to their eating and general psychopathology. Therapeutic approaches to correcting insecure attachment may be considered a possible choice to treat OC symptoms in AN. The study suggests a new psychopathological perspective to understand the meaning of obsessive-compulsive symptoms in AN.
Manufacturing Migration and Trade Embodied Carbon Transfer: Empirical Evidence From China and Thailand
Authors: wu jian , Cui Chunying , Mei Xiaolong , Xu Qingsong , Zhang Pu 
Published: April 2021

Abstract
At present, China's carbon emissions rank first in the world, which not only brings huge challenges to the sustainable development of China's economy, but also brings more pressure from public opinion in the international community. In 2020, ASEAN has become China's largest trading partner, and Thailand, due to its unique industrial structure and investment environment, will surely become one of the main ASEAN countries to undertake the transfer of China's manufacturing industry. Over the years, the shift of carbon emissions by the continuous transfer of a large number of basic manufacturing industries from China to Thailand promoted the release of China's carbon emission pressure. In this article, on the basis of the data of import and export commodities between China and Thailand from 2012 to 2017, the input-output model is carried out to analyze the energy consumption of China's various industries, and three periods, namely 2012, 2015, and 2017, are used to be key periods to calculate the embodied carbon of China's manufacturing migration and Sino-Thailand trade. The empirical results show that the transfer of China's manufacturing to Thailand from 2012 to 2017 has continued to rise. The transfer of Chinese manufacturing to Thailand is positively correlated with the carbon emissions of trade between the two countries, which has promoted the relief of China's pressure on energy conservation and emission reduction. Therefore, government departments should formulate differentiated and stable domestic manufacturing policies; spend on the development of advanced manufacturing industries with low energy consumption and high technology density; encourage the relocation of industries with low technology density and high carbon emissions to effectively reduce environmental pressure in China.
Antibacterial and Wound Healing Activities of Silver Nanoparticles Embedded in Cellulose Compared to Other Polysaccharides and Protein Polymers
Authors: Alavi Mehran , Varma Rajender S. 
Published: April 2021

Abstract
The aggregation of silver nanoparticles (AgNPs) in colloidal solution and the oxidative cytotoxicity towards human cells are two major hindrances for their thriving medicinal applications. Their incorporation in natural polymers such as cellulose, chitosan, alginate, collagen, gelatin, silk fibroin, carrageenan, hyaluronic acid, keratin and starch may be an alluring alternative strategy to sidestep these complications and attaining the advantageous wound dressings. Biocompatibility, bioavailability, biodegradability, and inherent therapeutic properties known for theses polymers, would accelerate the healing of infected chronic wounds. However, the low thermal stability, mechanical strength, rapid biodegradation, and weak washing resistance properties are some of the limitations for these polymers. Herein, recent advances, present challenges and future perspective for AgNPs incorporated nanocomposites (NCs) are discussed to realize ideal antibacterial activities by exploiting the abundant natural biopolymers.
Flavopiridol Mitigates the Progression of Monocrotaline-Induced Pulmonary Hypertension in Rats by Targeting Cyclin-dependent Kinase 9
Authors: Jia Qi , Hu Zhiqiang , Song Nannan , Mao Weike 
Published: April 2021

Abstract
Purpose: To investigate the role of cyclin-dependent kinase 9 (CDK9) and the therapeutic potential of CDK9 inhibitor (flavopiridol) in monocrotaline (MCT)-induced pulmonary hypertension.Methods: In vivo experiments, pulmonary hypertension rats were established by a single intraperitoneal injection of MCT (60 mg/kg) for 2 weeks and treated with flavopiridol (5 mg/kg, i.p., twice a week) or vehicle for 2 weeks. In vitro experiments, human pulmonary artery smooth muscle cells (HPASMCs) were treated with flavopiridol (0.025-1μM) or vehicle under hypoxic condition. Hemodynamic recording, right ventricle and lung histology, isolation of pulmonary arterial tissues were performed. The expressions of CDK9, RNA polymerase II, c-Myc, Mcl-1 and survivin were determined by qRT-PCR and western blotting, proliferation and apoptosis of PASMCs were also assayed.Results: CDK9 was upregulated in both rat pulmonary arterial tissues and HPASMCs. Upregulation of CDK9 increased the phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (RNA pol II) on serine-2, promoting the expression of prosurvival and antiapoptotic proteins (c-Myc, Mcl-1 and survivin). Furthermore, treatment with flavopiridol (5 mg/kg) significantly alleviated pulmonary artery remodeling and partially reversed the progression of monocrotaline-induced pulmonary hypertension. Consistently, flavopiridol (0.5 μM) treatment decreased the proliferation and induced the apoptosis of cultured HPASMCs under hypoxic conditions. As a result of CDK9 inhibition and subsequent inhibition of RNA pol II CTD phosphorylation at serine 2, flavopiridol decreased c-Myc, Mcl-1 and survivin expressions in isolated pulmonary small arteries, leading to cell growth inhibition and apoptosis. Conclusion: Flavopiridol mitigates the progression of monocrotaline-induced pulmonary hypertension in rats by targeting cyclin-dependent kinase 9.
Pathological Effects of Graded Doses of Aflatoxin B1 on the Development of Testes in Juvenile White Leghorn Males
Authors: Ashraf Anas , Saleemi Muhammad Kashif , Mohsin Mashkoor , Gul Shafia Tehseen , zubair muhammad , Muhammad Faqir , Bhatti Sheraz Ahmad , Hameed Muhammad Raza , Imran Muhammad , Irshad Hamid , Zaheer Iqra , Ahmed Ishtiaq , Raza Ahmad , Qureshi Anas Sarwar , Khan Ahrar 
Published: April 2021

Abstract
Current experiment was planned to investigate the deleterious effects of the graded dose of aflatoxin B1 (AFB1) on White Leghorn Male Birds. For this purpose, 100 birds of 8 week age were divided into 4 equal groups and reared on feed contaminated with different doses of AFB1 for 10 weeks. Group A was kept as a control group and was fed with normal toxin free diet, group B, C, and D were offered feed containing 100 ppb, 200 ppb, and 400 ppb of AFB1 respectively. The birds were euthanized at the 4th and 10th week of the experiment. Clinical signs, behavioral changes, absolute and relative organ weight of testes, sperm motility were measured. Cellular immune response was observed through CCA, P-HAP, and antibody response against SRBC. Results showed a dose-dependent decline in the immune response of birds with the increase in the level of AFB1 in the feed. A significant decrease in the serum levels of testosterone, prolactin, and LH was observed. Grossly, testicular size and volume were reduced in ABF1 fed birds while histological examination showed mild to moderate and severe necrosis of testicular parenchyma, with partial to complete arrest of spermatogenesis. Very few spermatozoa were found in group C while they were almost absent in group D which was offered a diet containing 400 ppb AFB1. The above-mentioned results showed that AFB1 had severe toxic effects on the reproductive and immunological parameters of WLH birds in a dose-dependent manner.
Predictive Ability of the G8 Screening Test to Determine Probable Sarcopenia and Abnormal Comprehensive Geriatric Assessment in Older Patients with Solid Malignancies
Authors: Cavusoglu Cagatay , Tahtaci Gozde , Dogrul Rana Tuna , Ileri Ibrahim , Yildirim Funda , Candemir Burcu , Kizilarslanoglu Muhammet Cemal , Uner Aytug , Goker Berna 
Published: April 2021

Abstract
Background: Pre-treatment evaluation for sarcopenia is recommended in cancer patients. We aimed to investigate whether the G8 screening test can detect probable sarcopenia and is valid and reliable compared to comprehensive geriatric assessment (CGA) in Turkish older adults with solid cancers.Methods: We included solid cancer patients referred to a single center. Probable sarcopenia and abnormal CGA were defined as low handgrip strength and impairment in at least one of the CGA tests, respectively. Receiver operating characteristic curve analyses evaluated the test’s predictive ability. Intra-rater and inter-rater reliabilities were assessed.Results: The median age of the 76 patients included was 72 (65–91) years. There was a moderate correlation between handgrip strength and the G8 test total score. The sensitivity and specificity of the G8 test to detect probable sarcopenia alone were 50% and 92%, respectively (area under the curve [AUC]: 0.747; p<0.001); to determine abnormal CGA plus probable sarcopenia were 93.33% and 86.89%, respectively (AUC: 0.939; p<0.001), and to detect abnormal CGA alone were 79.63% and 95.45%, respectively (AUC: 0.893; p<0.001). The G8 test results agreed with those of CGA (κ=0.638; p<0.001). Both inter- and intra-rater assessments of G8 scores revealed a strong agreement (Interclass correlation coefficient (ICC)=0.979, p<0.001 and ρ=0.994, p<0.001, respectively). Conclusions: The Turkish version of the G8 test is a good screening tool to detect probable sarcopenia alone and in conjunction with abnormal CGA in older patients with solid malignancies. The G8 screening tool may be useful in detecting probable sarcopenia in Turkish older adults with solid cancers.
Silodosin as a predisposing factor of Intraoperative Floppy Iris Syndrome (IFIS): an observational propensity score-matching cohort study
Authors: Christou Chrysanthos D. , Kourouklidou Marianna , Mataftsi Asimina , Oustoglou Eirini , Ziakas Nikolaos , Tzamalis Argyrios 
Published: April 2021

Abstract
Purpose: To evaluate the correlation between silodosin and Intraoperative Floppy Iris Syndrome (IFIS) and compare it with other a1- adrenergic receptor antagonists (a1-ARAs) and other factors predisposing to IFIS.Methods: From the cases who underwent phacoemulsification between 2014 and 2020, we identified all patients who, during their preoperative assessment, reported an a1-ARAs intake (exposed group). These patients were matched utilizing a propensity score matching analysis, with an otherwise homogenous group of patients (control group), based on demographics and systemic/ocular comorbidities.Results: 350 patients were included in each group. In the exposed group, 177 (50.6%) patients were exposed to tamsulosin, 105 (30%) to alfuzosin, 43 (12.2%) to silodosin. Regarding IFIS, it was observed in 21.5% of patients on tamsulosin (38/177), 11.4% on alfuzosin (12/105), 37.2% on silodosin (16/43), and 3.4% in the controlled group (12/350). In a multiple regression model analysis, the only two factors that were significantly associated with IFIS development were silodosin and tamsulosin yielding an adjusted odds ratio of 8.471 (95%CI: 4.005-17.920), and 3.803 (95%CI: 2.231-6.485), respectively.Conclusion: Silodosin has been demonstrated as a predisposing factor, strongly correlated with IFIS development. These results should increase awareness to cataract surgeons, to carefully assess their patients preoperatively for exposure to silodosin, and employ the appropriate prophylactic measures to ameliorate the impact of silodosin intake on the surgical outcome.
Quantum Dot Assisted Luminescent Hexarhenium Cluster Dye for a Transparent Luminescent Solar Concentrator
Authors: Choi Jun , Kim Kyungkon , Kim Sung-Jin 
Published: April 2021

Abstract
A luminescent solar concentrator (LSC) is a solar-light harvesting device that concentrates light on a photovoltaic cell placed at the edge of an LSC panel to convert it into electricity. The nano-sized inorganic-organic cluster complex (dMDAEMA)4[Re6S8(NCS)6] (where dMDAEMA is 2-dimethyl amino ethyl methacrylate) is a promising candidate for LSC luminophores due to its downshifted broad photoluminescence suitable for photovoltaic cells. However, the low quantum yield (QY) of RMC limits the performance. Here, zinc-doped CuGaS/ZnS core/shell quantum dots (ZQD) were used as energy transferring donor with high QY to improve the performance of the LSC. The two metal chalcogenide luminophores, RMC and ZQD, are chemically suitable for dispersion in an amphiphilic polymer matrix, producing a transparent waveguide with suppressed reabsorption and extended harvesting coverage of the solar spectrum. We achieved an ηopt of 3.47% and a PCE of 1.23% while maintaining greater than 80% transparency in the visible range. The high performance of this dual-dye LSC with suppressed reabsorption, and scattering losses is not only due to uniform dispersion of dyes in a polymer matrix, but also energy transfer from ZQD to RMC. This report suggests a new possibility for promising various multi-dye LSCs for use in building-integrated photovoltaic windows.
Effects of Dietary Protein and Lipid Levels on Growth, Body Composition, Blood Biochemistry, Antioxidant Capacity and Ammonia Excretion of European Grayling (Thymallus Thymallus)
Authors: Rahimnejad Samad , Dabrowski Konrad , Izquierdo Marisol , Malinovskyi Oleksandr , Kolářová Jitka , Policar Tomas 
Published: April 2021

Abstract
Background: This study evaluated growth, body composition, blood biochemistry, antioxidant capacity, innate immunity and ammonia excretion of European grayling (Thymallus thymallus) fed diets containing different protein and lipid contents. Six diets were produced to contain 30, 40 or 50% protein with 10 or 20% lipid and fed to triplicate groups (100 fish per replicate) of fish (25.2 ± 0.28 g) to visual satiety twice daily for 12 weeks. Results: Fish growth was enhanced (P ˂ 0.05) as protein increased from 30 to 40% and plateaued thereafter. Enhancing protein and lipid content of diet led to reduced feed intake and improved feed efficiency. Moreover, protein efficiency ratio increased at higher lipid level while lower values were recorded at higher protein levels. Increasing dietary lipid content led to the enhancement of viscerosomatic index and intraperitoneal fat ratio. An interaction of protein and lipid was found on whole-body lipid, and muscle lipid was responsive to dietary lipid level. Muscle ARA, EPA and Ʃn-6 LC-PUFA contents enhanced by increasing dietary protein level. Moreover, increasing fat content of diet led to enhanced muscle linoleic acid, linolenic acid, ƩMUFA, Ʃn-6, DHA/EPA and n-6/n-3. However, EPA, DHA, Ʃn-6 LC-PUFA, Ʃn-3, Ʃn-3 LC-PUFA and EPA/ARA decreased at higher dietary lipid level. Serum triglyceride (TG) concentration and lactate dehydrogenase (LDH) activity decreased as dietary protein level increased while an opposite effect was observed for cholesterol (CHO) concentration. Increasing fat content of diet led to enhanced serum TG, CHO and glucose concentrations and reduced alanine aminotransferase, aspartate amino transferase and LDH activities. Serum malondialdehyde concentration was enhanced by increasing both dietary protein and lipid contents. Furthermore, serum myeloperoxidase activity was enhanced at higher dietary lipid level. Water total ammonium nitrogen (TAN) concentration was measured after 5 and 24 h of last feeding, and the results indicated the reduction of ammonia excretion as dietary lipid content increased. Conclusions: These findings suggest that 40% dietary protein can support optimal growth of juvenile European grayling and increasing lipid content from 10 to 20% can improve feed utilization and reduce ammonia excretion to the rearing water.
Piperine Improves Experimental Autoimmune Encephalomyelitis (EAE) in Lewis Rats through its Neuroprotective, Anti-inflammatory and Anti-Oxidant Effects
Authors: Nasrnezhad Reza , Halalkhor Sohrab , Sadeghi Farzin , Pourabdolhossein Fereshteh 
Published: April 2021

Abstract
Inflammation, demyelination, glial activation, and oxidative damage are the most pathological hallmarks of multiple sclerosis (MS). Piperine, a main bioactive alkaloid of black pepper, possesses antioxidant, anti-inflammatory and neuroprotective properties whose therapeutic potential has been less studied in the experimental autoimmune encephalomyelitis (EAE) models. In this study, the efficiency of peprine on progression of EAE model and myelin repair mechanisms was investigated. EAE was induced in female Lewis rats and piperine and its vehicle were daily administrated intraperitoneally from day 8 to 29 post immunization. We found that peperine alleviated neurological deficits and EAE disease progression. Luxol fast blue and H&E staining and immuno-staining of lumbar spinal cord cross sections confirmed that piperine significantly reduced the extent of demyelination, inflammation and immune cell infiltration and inhibited microglia and astrocyte activation. Gene expression analysis in lumbar spinal cord showed that piperine treatment decreased the level of pro-inflammatory cytokines (TNF-α, IL-1β) and iNOS and enhanced IL-10, Nrf-2, HO-1and MBP expressions. Piperine supplementation also enhanced the total antioxidant capacity (FRAP) and reduced the level of oxidative stress marker (MDA) in the CNS of EAE rats. Finally, we found that piperine has anti-apoptotic and neuroprotective effect in EAE through reducing caspase-3 (apoptosis marker) and enhancing BDNF and NeuN expressing cells. This study strongly indicates that piperine has a beneficial effect on the EAE progression and could be considered as a potential therapeutic target for MS treatment. Upcoming clinical trials will provide the deep understanding of piperine’s role for the treatment of the MS.
Age Estimation of Arabian Mares by Incisors Morphometry and Dentition Changes
Authors: Khazaeel Kaveh , Pesarakli Hamid , Mashhadi Alireza Ghadrdan , Borujeni Mahdi Pourmahdi 
Published: April 2021

Abstract
Accurate estimation of horse's age based on the condition of the tooth status is necessary as a scientific and artistic technique, which has not been performed so far in genuine Arabian horses of Khuzestan (southern west of Iran). The purpose of study was to investigate the age-dependent changes in morphology and morphometry of the incisors in the Arabian mares of Khuzestan in order to age estimation and to compare the estimated dental age with ancestral age. In this study, eighty-four Arabian mares of Khuzestan were examined at a number of equestrian clubs. Then, images were taken with a digital camera from the vestibular and occlusal surfaces of the lower incisors. Parameters of deciduous and permanent teeth eruption and their number, occlusal surface changes in lower incisors including appearance and disappearance of cup, enamel spot, dental star and appearance and changes of Galvayne’s groove in upper corner incisor were investigated. Comparison of clinical crown length of incisors in each group showed that first, second and third incisors (I1, I2, and I3) had the maximum to minimum crown length, respectively. The correlation between ancestral age and clinical crown length was strong in I1 (r = 0.73, p ≤ 0.001), I2 (r = 0.8, p ≤ 0.001) and I3 (r = 0.81, p ≤ 0.001) in the Arabian mares of Khuzestan. The correlation of estimated dental age with ancestral age in the Arabian mares of Khuzestan was very strong (r = 0.992, p ≤ 0.001). Therefore, the dental age estimation in the Arabian mares of Khuzestan seems to be very close to the actual age of the animal.
Formation and recycling of an active epigenetic mark mediated by cell cycle-specific RNAs
Authors: Tenen Daniel , Ebralidze Alexander , Angarica Vladimir , Liu Yanjing , Kappei Dennis , Tenen Danielle , Monteleone Emanuele , Coffey Rory , Magallanes Roberto , Ummarino Simone , Wanet Anais , Bassal Mahmoud , Trinh Bon , Sheen Mee Rie , Benoukraf Touati , Robinson Colyn Crane , Ruscio Annalisa Di , Budnik Bogdan , Zhang Haoran , Poli Valeria , Zhang Yanzhou 
Published: May 2021

Abstract
The mechanisms by which epigenetic modifications are established in gene regulatory regions of active genes remain poorly understood. The data presented show that the establishment and recycling of a major epigenetic mark, the acetylated form of the replacement histone H2A.Z, is regulated by cell cycle-specific long noncoding RNAs encoded in regions adjacent to the promoters of active genes. These transcripts, termed SPEARs (S Phase EArly RNAs), are induced in early S phase: their expression precedes that of the downstream genes on which they exert their regulatory action. SPEARs drive the modification and deposition of the acetylated form of histone H2A.Z by bringing together the replacement histone and the histone acetyl transferase TIP60. This widespread bimodal pathway constitutes a novel RNA-mediated mechanism for the establishment of epigenetic marks and cell-specific epigenetic profiles, thereby providing a unifying explanation for the accuracy and persistence of epigenetic marks on chromatin.
Effect of the Variability of Wind Forcing on ENSO Simulation in an OGCM: Case of Canonical and Protracted Event
Authors: Arora Anika 
Published: April 2021

Abstract
This study is an attempt to understand the onset and evolution of canonical El Niño (~ 18–24 months; CE) and protracted El Niño (> greater than 3 years; PE) compared to the normal state (NS) in an ocean model. Indo-Pacific warm pool indicates higher values of SST before the onset of strong canonical El Niño compared to the normal state and protracted El Niño. The ocean model used in the study shows systematic SST bias in the Indo-Pacific Ocean with higher (cooler) values of temperature in western (eastern) Pacific during NS, CE, and PE exhibiting La Niña like conditions. The ocean model exhibits deeper thermocline depth in the western equatorial Pacific Ocean (PO) during PE and CE compared to NS indicating higher values of heat content (warm water volume). Despite the presence of higher warm water volume in the western PO before the onset of El Niño, the difference in the variability of surface wind forcing during the preceding months determines the type of El Niño. The interplay of surface wind forcing among the NS, PE, and CE states without altering the ocean state can modify the subsurface propagation in the equatorial Pacific Ocean. A change in longitudinal extent of upwelling Kelvin waves towards eastern PO along with the change in surface wind forcing decides the fate of El Niño in the eastern Pacific.