bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors that influence international nursing students’ experiences and perceptions of their learning environments: a scoping review protocol
Authors: Tallon Mary , Brown Janie , Solomons Terena , Kalembo Fatch , Bosco Anna , Lim Eric , Ngune Irene , Moore Kate , Wilson Sally 
Published: July 2021

ABSTRACT

Objective:
The objective of this review is to explore the research on factors that influence international undergraduate nursing students’ experiences and perceptions of their learning environment.

Introduction:
International nursing students bring valuable cultural and economic opportunities to universities and health care. It is important that their clinical learning experiences are positive. Factors that influence nursing students’ experiences may include cultural and communication differences, diversity related to health care systems, learning and teaching strategies, and programs to improve communication. International nursing students’ experiences and perceptions are reported in terms of expressed confidence, perceived competence, and levels of satisfaction. A scoping review is required to identify what is known and to identify the knowledge gaps in this area.

Inclusion criteria:
International nursing students are those who are enrolled in an undergraduate nursing program in a higher-education institution in a country other than their own. International students studying vocational nursing and exchange students will be excluded. The learning environment is considered to be one in which any person who may influence patient care learns. Primary research, both qualitative and quantitative methods, published since 1995 in any language that the research team can translate will be included.

Methods:
This review follows the JBI methodology for scoping reviews. Data extraction will include the factors influencing students’ experiences and the concepts that were explored. Data analysis will include frequencies of concepts and associations between them. Results will be presented in tabular form and mind maps.

Scoping review registration number:
Open Science Framework (osf.io/r4v6q)
Experiences of nurses caring for respiratory patients during the first wave of the COVID-19 pandemic: an online survey study
Authors: Roberts Nicola J , Kelly Carol A , Lippiett Kate A , Ray Emma , Welch Lindsay 
Published: July 2021

BackgroundNurses have been at the forefront of the pandemic response, involved in extensive coordination of services, screening, vaccination and front-line work in respiratory, emergency and intensive care environments. The nature of this work is often intense and stress-provoking with an inevitable psychological impact on nurses and all healthcare workers. This study focused on nurses working in respiratory areas with the aim of identifying and characterising the self-reported issues that exacerbated or alleviated their concerns during the first wave of the COVID-19 pandemic.MethodsAn online survey was developed consisting of 90 questions using a mixture of open-ended and closed questions. Participant demographic data were also collected (age, gender, ethnicity, number of years qualified, details of long-term health conditions, geographical location, nursing background/role and home life). The online survey was disseminated via social media and professional respiratory societies (British Thoracic Society, Primary Care Respiratory Society, Association of Respiratory Nurse Specialists) over a 3-week period in May 2020 and the survey closed on 1 June 2020.ResultsThe study highlights the experiences of nurses caring for respiratory patients during the first wave of the pandemic in early 2020. Concerns were expressed over the working environment, the supply and availability of adequate protective personal equipment, the quality of care individuals were able to deliver, and the impact on mental health to nurses and their families. A high number provided free-text comments around their worries and concerns about the impact on their household; these included bringing the virus home, the effect on family members worrying about them, mental health and the impact of changing working patterns, and managing with children. Although both formal and informal support were available, there were inconsistencies in provision, highlighting the importance of nursing leadership and management in ensuring equity of access to services.ConclusionsSupport for staff is essential both throughout the pandemic and afterwards, and it is important that preparation of individuals regarding building resilience is recognised. It is also clear that psychological support and services for nurses and the wider healthcare team need to be available and quickly convened in the event of similar major incidents, either global or local.
Underdevelopment of the gut microbiota and bacteria species as non-invasive markers of prediction in children with autism spectrum disorder
Authors: Wan Yating , Zuo Tao , Xu Zhilu , Zhang Fen , Zhan Hui , CHAN Dorothy , Leung Ting-Fan , Yeoh Yun Kit , Chan Francis K L , Chan Ruth , Ng Siew C 
Published: July 2021

ObjectiveThe gut microbiota has been suggested to play a role in autism spectrum disorder (ASD). We postulate that children with ASD harbour an altered developmental profile of the gut microbiota distinct from that of typically developing (TD) children. Here, we aimed to characterise compositional and functional alterations in gut microbiome in association with age in children with ASD and to identify novel faecal bacterial markers for predicting ASD.DesignWe performed deep metagenomic sequencing in faecal samples of 146 Chinese children (72 ASD and 74 TD children). We compared gut microbial composition and functions between children with ASD and TD children. Candidate bacteria markers were identified and validated by metagenomic analysis. Gut microbiota development in relation to chronological age was assessed using random forest model.ResultsASD and chronological age had the most significant and largest impacts on children’s faecal microbiome while diet showed no correlation. Children with ASD had significant alterations in faecal microbiome composition compared with TD children characterised by increased bacterial richness (p=0.021) and altered microbiome composition (p<0.05). Five bacterial species were identified to distinguish gut microbes in ASD and TD children, with areas under the receiver operating curve (AUC) of 82.6% and 76.2% in the discovery cohort and validation cohort, respectively. Multiple neurotransmitter biosynthesis related pathways in the gut microbiome were depleted in children with ASD compared with TD children (p<0.05). Developing dynamics of growth-associated gut bacteria (age-discriminatory species) seen in TD children were lost in children with ASD across the early-life age spectrum.ConclusionsGut microbiome in Chinese children with ASD was altered in composition, ecological network and functionality compared with TD children. We identified novel bacterial markers for prediction of ASD and demonstrated persistent underdevelopment of the gut microbiota in children with ASD which lagged behind their respective age-matched peers.
Basilar artery trunk aneurysm: clinical and angiographic outcomes of endovascular treatment
Authors: Sim Sook Young , Chung Joonho , Choi Jai Ho , Kim Myeong Jin , Shin Yong Sam , Lim Yong Cheol 
Published: July 2021

BackgroundBasilar artery (BA) trunk aneurysms are rare, and the clinical characteristics and outcomes of endovascular treatment (EVT) remain unclear. The purpose of this study was to report clinical and angiographic outcomes of BA trunk aneurysm treated with EVT and to analyze risk factors for unfavorable outcomes.MethodsFrom October 2004 to December 2020, a total of 40 patients with BA trunk aneurysms underwent EVT. Clinical characteristics and outcomes were evaluated retrospectively from a prospectively collected database. Of the 40 enrolled patients, nine were treated by coiling without stents, 17 were treated by stent-assisted coiling, six by stent only, five by flow diverters, and three by vertebral artery occlusion.ResultsIn total, 27 (67.5%) patients had subarachnoid hemorrhage as an initial presentation, and 20 (50.0%) had large/giant aneurysms. Procedure-related complications occurred in five patients (12.5%); favorable clinical outcome was achieved in 27 patients (67.5%); and six patients (15.0%) died. Favorable angiographic outcome was achieved in 26 (83.9%) of 31 patients who underwent follow-up angiography. Poor initial Hunt-and-Hess grade (OR 7.67, 95% CI 1.55 to 37.80; p=0.018) was the only independent risk factor for unfavorable clinical outcome. Large/giant aneurysm (OR 8.14, 95% CI 1.88 to 27.46; p=0.047) and long lesion (OR 14.25, 95% CI 1.48 to 69.80; p=0.013) were independent risk factors for unfavorable angiographic outcomes during follow-up.ConclusionsEVT might be a feasible option for this rare disease entity. Unfavorable angiographic outcome might be expected in a large/giant aneurysm or a long lesion. It can be difficult to treat BA trunk aneurysms by EVT, needing multiple procedures or various techniques due to diverse clinical and angiographic features.
Mapping out the space for new physics with leptonic and semileptonic $$B_{(c)}$$ decays
Authors: Fleischer Robert , Jaarsma Ruben , Tetlalmatzi-Xolocotzi Gilberto 
Published: July 2021

AbstractDecays ofBmesons with leptons in the final state offer an interesting laboratory to search for possible effects of physics from beyond the Standard Model. In view of puzzling patterns in experimental data, the violation of lepton flavour universality is an interesting option. We present a strategy, utilising ratios of leptonic and semileptonicBdecays, where the elements$$|V_{ub}|$$|Vub|and$$|V_{cb}|$$|Vcb|of the Cabibbo–Kobayashi–Maskawa (CKM) matrix cancel, to constrain the short-distance coefficients of (pseudo)-scalar, vector and tensor operator contributions. The individual branching ratios allow us then to extract also the CKM matrix elements, even in the presence of new-physics contributions. Bounds on unmeasured leptonic and semileptonic decays offer important additional constraints. In our comprehensive analysis, we give also predictions for decays which have not yet been measured in a variety of scenarios.
Design, fabrication and performance of enhanced reactive igniter through depositing Al/CuO nanolaminates onto NiCr micro-heater
Authors: Liu Wei , Ren Xiaoming , Xue Yan , Xie Ruizhen , Liu Lan 
Published: July 2021

As the most important component for MEMS-based pyrotechnics, the micrometer should generate enough energy to successfully ignite the next explosive. An enhanced reactive igniter was designed and fabricated through sputtering the Al/CuO nanolaminates onto the NiCr micro-heater to enhance the output energy of the NiCr micro-heater. The average thickness of the Al/CuO nanolaminate is 6.84 [Formula: see text]m, and the designed thickness is 6 [Formula: see text]m. The grain sizes of Al/CuO nanolaminates are not uniform, and the particle grains of the Al/CuO nanolaminates at the top are smaller than those at the bottom. When the applied currents passed through the igniter, the resistance of the igniter changed dynamically, leading to the igniter experiencing three stages. Compared to the bare NiCr micro-heater without depositing Al/CuO nanolaminates, the enhanced reactive igniter can successfully ignite Zr/KClO4 explosive, indicating that the Al/CuO nanolaminates could enhance the output capability of the NiCr micro-heater. It is of vital importance to guide the design of MEMS-based pyrotechnics.
Aeolian processes and landforms
Authors: Goudie Andrew S. 
Published: July 2021

Abstract
A number of major factors have driven the volume and nature of aeolian geomorphology in the second half of the twentieth century: the growth of process studies; the availability of remote sensing, the development of new dating techniques (e.g. optical dating), the utilization of new technologies (e.g. data loggers and global positioning systems); computer modelling of dune forms, wind action and sediment movement; the recognition of the importance of aeolian forms and processes in extraterrestrial settings (especially Mars); the role of aeolian dust in atmospheric processes; the search for analogues for ancient hydrocarbon-bearing strata; the appreciation of the importance of climatic changes in desert areas; a concern with what may happen to arid environments in a warmer world; and an increasing realization that aeolian phenomena could be hazardous. This chapter does not deal with coastal dunes, but concentrates on those of the major lower-latitude drylands. It discusses the main controls on dune forms, the nature of sand seas, ancient and modern, and the nature of dune sediments. It also shows that during the 1970s there was a burgeoning interest in dust storms. In addition, with the availability of remote sensing imagery, it was possible to see for the first time that wind-furrowed yardangs were striking features with a wide global distribution. The origin of closed depressions (pans) generated a large literature, and hypotheses for their formation were put forward that included wind erosion, solution, excavation by animals, karstic and pseudo-karstic solution, and tectonic subsidence. Remote sensing showed just how important they were in drylands. Other phenomena that attracted attention and some controversy were stone pavements and peri-desert loess. Finally, it is suggested that the nature of aeolian processes and forms will be modified in a warmer world.
Human–environment interactions during the mid-late Holocene and the Anthropocene – lessons from NW Indian plains and Bengal Delta
Authors: Dixit Yama , Biswas Sravani 
Published: July 2021

Abstract
The Indian subcontinent today houses about one-third of the global population and is one of the most vulnerable regions to future climate variability. This region has seen changes in civilizations, kingdoms and more recently political regimes, that were intricately linked to the changing environment over the mid–late Holocene. A comparative analysis of human–environment interaction within different regions at different time scales of the Quaternary is, however, lacking. In this paper we discuss the human–environment interactions taking case studies from two diverse time periods and geographically different regions from the Indian subcontinent. First, we review and analyse the role of environmental change in the evolution of Indus civilization on the northwestern Indian subcontinent during the mid–late Holocene and secondly, we discuss the role of both the anthropogenic activities and environmental change during the Anthropocene in shaping up the Bengal Delta. Overall, during the mid–late Holocene, Indus cultural transformations were driven by natural environmental changes, whereas the anthropogenic activities in the last few centuries have modified the Bengal deltaic landscape, which has intensified the impacts of natural disasters – in both cases a change in socio-political scenarios occurred. Such studies can be used as benchmarks to understand the future response of societies to environmental changes.
Tumor-Specific Major Histocompatibility-II Expression Predicts Benefit to Anti–PD-1/L1 Therapy in Patients With HER2-Negative Primary Breast Cancer
Authors: Gonzalez-Ericsson Paula I. , Wulfkhule Julia D. , Gallagher Rosa I. , Sun Xiaopeng , Axelrod Margaret L. , Sheng Quanhu , Luo Na , Gomez Henry , Sanchez Violeta , Sanders Melinda , Pusztai Lajos , Petricoin Emanuel , Blenman Kim R.M. , Balko Justin M. ,   I-SPY2 Trial Team
Published: July 2021

Abstract

Purpose:
Immunotherapies targeting PD-1/L1 enhance pathologic complete response (pCR) rates when added to standard neoadjuvant chemotherapy (NAC) regimens in early-stage triple-negative, and possibly high-risk estrogen receptor–positive breast cancer. However, immunotherapy has been associated with significant toxicity, and most patients treated with NAC do not require immunotherapy to achieve pCR. Biomarkers discerning patients benefitting from the addition of immunotherapy from those who would achieve pCR to NAC alone are clearly needed. In this study, we tested the ability of MHC-II expression on tumor cells, to predict immunotherapy-specific benefit in the neoadjuvant breast cancer setting.

Patients and Methods:
This was a retrospective tissue-based analysis of 3 cohorts of patients with breast cancer: (i) primary nonimmunotherapy-treated breast cancers (n = 381), (ii) triple-negative breast cancers (TNBC) treated with durvalumab and standard NAC (n = 48), and (iii) HER2-negative patients treated with standard NAC (n = 87) or NAC and pembrolizumab (n = 66).

Results:
HLA-DR positivity on ≥5% of tumor cells, defined a priori, was observed in 10% and 15% of primary non-immunotherapy–treated hormone receptor–positive and triple-negative breast cancers, respectively. Quantitative assessment of MHC-II on tumor cells was predictive of durvalumab + NAC and pembrolizumab + NAC (ROC AUC, 0.71; P = 0.01 and AUC, 0.73; P = 0.001, respectively), but not NAC alone (AUC, 0.5; P = 0.99).

Conclusions:
Tumor-specific MHC-II has a strong candidacy as a specific biomarker of anti–PD-1/L1 immunotherapy benefit when added to standard NAC in HER2-negative breast cancer. Combined with previous studies in melanoma, MHC-II has the potential to be a pan-cancer biomarker. Validation is warranted in existing and future phase II/III clinical trials in this setting.
Pharmaceutical Interference of the EWS-FLI1–driven Transcriptome By Cotargeting H3K27ac and RNA Polymerase Activity in Ewing Sarcoma
Authors: Heisey Daniel A.R. , Jacob Sheeba , Lochmann Timothy L. , Kurupi Richard , Ghotra Maninderjit S. , Calbert Marissa L. , Shende Mayuri , Maves Yuki Kato , Koblinski Jennifer E. , Dozmorov Mikhail G. , Boikos Sosipatros A. , Benes Cyril H. , Faber Anthony C. 
Published: July 2021

Abstract
The EWSR1-FLI1 t(11;22)(q24;q12) translocation is the hallmark genomic alteration of Ewing sarcoma, a malignancy of the bone and surrounding tissue, predominantly affecting children and adolescents. Although significant progress has been made for the treatment of localized disease, patients with metastasis or who relapse after chemotherapy have less than a 30% five-year survival rate. EWS-FLI1 is currently not clinically druggable, driving the need for more effective targeted therapies. Treatment with the H3K27 demethylase inhibitor, GSK-J4, leads to an increase in H3K27me and a decrease in H3K27ac, a significant event in Ewing sarcoma because H3K27ac associates strongly with EWS-FLI1 binding at enhancers and promoters and subsequent activity of EWS-FLI1 target genes. We were able to identify targets of EWS-FLI1 tumorigenesis directly inhibited by GSK-J4. GSK-J4 disruption of EWS-FLI1-driven transcription was toxic to Ewing sarcoma cells and slowed tumor growth in patient-derived xenografts (PDX) of Ewing sarcoma. Responses were markedly exacerbated by cotreatment with a disruptor of RNA polymerase II activity, the CDK7 inhibitor THZ1. This combination together suppressed EWS-FLI1 target genes and viability of ex vivo PDX Ewing sarcoma cells in a synergistic manner. In PDX models of Ewing Sarcoma, the combination shrank tumors. We present a new therapeutic strategy to treat Ewing sarcoma by decreasing H3K27ac at EWS-FLI1–driven transcripts, exacerbated by blocking phosphorylation of the C-terminal domain of RNA polymerase II to further hinder the EWS-FLI1–driven transcriptome.
Phase I Open-Label Study Evaluating the Safety, Pharmacokinetics, and Preliminary Efficacy of Dilpacimab in Patients with Advanced Solid Tumors
Authors: Gordon Michael S. , Nemunaitis John , Barve Minal , Wainberg Zev A. , Hamilton Erika P. , Ramanathan Ramesh K. , Sledge George W. , Yue Huibin , Morgan-Lappe Susan E. , Blaney Martha , Kasichayanula Sreeneeranj , Motwani Monica , Wang Lan , Naumovski Louie , Strickler John H. 
Published: July 2021

Abstract
Dilpacimab (formerly ABT-165), a novel dual-variable domain immunoglobulin, targets both delta-like ligand 4 (DLL4) and VEGF pathways. Here, we present safety, pharmacokinetic (PK), pharmacodynamic (PD), and preliminary efficacy data from a phase I study (trial registration ID: NCT01946074) of dilpacimab in patients with advanced solid tumors. Eligible patients (≥18 years) received dilpacimab intravenously on days 1 and 15 in 28-day cycles at escalating dose levels (range, 1.25–7.5 mg/kg) until progressive disease or unacceptable toxicity. As of August 2018, 55 patients with solid tumors were enrolled in the dilpacimab monotherapy dose-escalation and dose-expansion cohorts. The most common treatment-related adverse events (TRAE) included hypertension (60.0%), headache (30.9%), and fatigue (21.8%). A TRAE of special interest was gastrointestinal perforation, occurring in 2 patients (3.6%; 1 with ovarian and 1 with prostate cancer) and resulting in 1 death. The PK of dilpacimab showed a half-life ranging from 4.9 to 9.5 days, and biomarker analysis demonstrated that the drug bound to both VEGF and DLL4 targets. The recommended phase II dose for dilpacimab monotherapy was established as 3.75 mg/kg, primarily on the basis of tolerability through multiple cycles. A partial response was achieved in 10.9% of patients (including 4 of 16 patients with ovarian cancer). The remaining patients had either stable disease (52.7%), progressive disease (23.6%), or were deemed unevaluable (12.7%). These results demonstrate that dilpacimab monotherapy has an acceptable safety profile, with clinical activity observed in patients with advanced solid tumors.
Imaging Reveals Importance of Shape and Flexibility for Glomerular Filtration of Biologics
Authors: Rafidi Hanine , Estevez Alberto , Ferl Gregory Z. , Mandikian Danielle , Stainton Shannon , Sermeño Lauren , Williams Simon P. , Kamath Amrita V. , Koerber James T. , Boswell C. Andrew 
Published: July 2021

AbstractAdvances in antibody engineering have enabled the construction of novel molecular formats in diverse shapes and sizes, providing new opportunities for cancer immunotherapeutic drug discovery while also revealing limitations in knowledge of structure–activity relationships. The current understanding of renal filtration originates largely from data reported for dextrans, IgG, albumin, and selected globular proteins. For a one-armed IgG-based T-cell imaging agent, we observed higher renal signal than typically observed for bivalent IgGs, prompting us to explore the factors governing renal filtration of biologics. We constructed a small representative library of IgG-like formats with varied shapes and hinge flexibilities falling broadly into two categories: branched molecules including bivalent IgG and (scFv)2Fc, and nonbranched molecules including one-armed IgG, one-armed IgG with stacked Fab, and one-armed IgG with a rigid IgA2 hinge. Transmission electron microscopy revealed Y-shaped structures for the branched molecules and pseudo-linear structures for the nonbranched molecules. Single-photon emission CT imaging, autoradiography, and tissue harvest studies demonstrated higher renal uptake and catabolism for nonbranched molecules relative to branched molecules. Among the nonbranched molecules, the one-armed IgG with rigid IgA2 hinge molecule demonstrated higher kidney uptake and decreased systemic exposure relative to molecules with a more flexible hinge. Our results show that differences in shape and hinge flexibility drive the increased glomerular filtration of one-armed relative to bivalent antibodies and highlight the practical advantages of using imaging to assess renal filtration properties. These findings are particularly relevant for T-cell–dependent bispecific molecules, many of which have nonstandard antibody structures.