bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE IMPROVING OF STUDENT LEARNING OUTCOMES BY USING SUNDA MANDA GAME MEDIA
Authors: SARI DINAR AYU MIRUNGGAN 
Published: May 2021

ABSTRACTThis study aims to improve student learning outcomes by using Sunda Manda game media. This research was used Classroom Action Research (CAR) from Kemmis and Mc. Taggart with two cycles, each cycles consist of three meetings with several stages namely planning, implementing, observing, and reflecting. It was conducted in the fourtth grade of SD 1 Prambatan Lor with 37 students as the research subject. Data collection techniques are observation, interview, and documentation. Analysis of the data of this research is using quantitative and qualitative research. The result of the study showed an increase in student learning outcomes in the realm of knowledge in the first cycle of social studies, the total number of students was 26 students with an average of 72,76 (70,27%), the complete of Bahasa Indonesia content of students was 25 students with an average of 73,49 (67,57%) while the second cycle of social studies of students who completed were 34 students with an average of 80,21 (91, 89%), in Bahasa Indonesia’s subject who completed the task were 32 students with an average of 79,51 (86,49%). Learning outcomes in the realm of attitude in the first cycle with an average of 74,38 (61,98%) and the second cycle with an average of 96 (80,00%). Learning outcomes in the realm of skills in the first cycle with an average of 51,76 (61,62%) and the second cycle with an average of 66,84 (79,57%). The results of these studies at the fourth grade student at SD 1 Prambatan Lor have increased with the innovation in the learning media in the form of Sunda Manda game. The conclusion of this study is an increase in student learning outcomes by using traditional Sunda Manda game media at SD 1 Prambatan Lor. Keyword: Learning Outcomes, Sunda Manda Game, Visualization Auditory Kinesthetic.
INFLUENCE OF SUBSTITUTES ON THE RATE OF THE REACTION OF ORTHOSUBSTITUTED BENZOIC ACIDS WTH ANILINE, CATALYZED BY POLYBUTOXYTITANATES
Authors: Shteinberg Leon 
Published: May 2021

The polybutoxytitanates catalysis of aniline acylation by orthosubstituted benzoic acids leads to the production of substituted benzanilides. Catalytic rate constants of the second order reaction (the first with respect to aniline and ortho-substituted benzoic acid; boiling ortho=xylene, 145°C) correlate well according to the Hammett and Bronsted equations with straight line segments with ρ=1.93 and α=0.66, in contrast to the reaction of aniline with meta- and parasubstituted benzoic acids and substituted anilines with benzoic acid. This dependence drops out 2=nitrobenzoic and 1=naphthoic acids, which have relatively low reactivity and the greatest steric hindrances both for nucleophilic attack by aniline and for possible coordination with catalytically active centers of the corresponding ortho-substituted titanium polybutoxybenzoates formed in situ.
Based on these data, the previously proposed mechanism of bifunctional catalysis due to titanium polybutoxybenzoates and their complexes with meta- and parasubstitutedbenzanilides was supplemented by the possibility of the steric inhibition of reaction by the most bulky substituents and chelate structures formation of orthosubstituted benzoic acids and their anilides with individual titanium atoms of the catalyst, as well as the simulta­neous H-bonding of the amino group hydrogen atoms of aniline, which leads to its activation to a nucleophilic attack, with a carbonyl group and an orthopositioned substituent of the orthobenzoate ligand in the coordination sphere of titanium. Taking into account such chelation and steric barriers, as well as inhibition of acid catalysis due to the formation of the imide form of anilides, containing electron-withdrawing substituents, the equations for the rate constants of the catalytic reaction of ortho-substituted benzoic acids with aniline are derived, corresponding to the experimentally obtained Hammett dependence.
Low-Lying Electronic States of the Nickel Dimer
Authors: Tamukong Patrick K. , Hoffmann Mark R. 
Published: May 2021

The generalized Van Vleck second order multireference perturbation theory (GVVPT2) method was used to investigate the low-lying electronic states of Ni2. Because the nickel atom has an excitation energy of only 0.025 eV to its first excited state (the least in the first row of transition elements), Ni2 has a particularly large number of low-lying states. Full potential energy curves (PECs) of more than a dozen low-lying electronic states of Ni2, resulting from the atomic combinations 3F4 + 3F4 and 3D3 + 3D3, were computed. In agreement with previous theoretical studies, we found the lowest lying states of Ni2 to correlate with the 3D3 + 3D3 dissociation limit, and the holes in the d-subshells were in the subspace of delta orbitals (i.e., the so-dubbed δδ-states). In particular, the ground state was determined as X 1Γg and had spectroscopic constants: bond length (Re) = 2.26 Å, harmonic frequency (ωe) = 276.0 cm−1, and binding energy (De) = 1.75 eV; whereas the 1 1Σg+ excited state (with spectroscopic constants: Re = 2.26 Å, ωe = 276.8 cm−1, and De = 1.75) of the 3D3 + 3D3 dissociation channel lay at only 16.4 cm−1 (0.002 eV) above the ground state at the equilibrium geometry. Inclusion of scalar relativistic effects through the spin-free exact two component (sf-X2C) method reduced the bond lengths of both of these two states to 2.20 Å, and increased their binding energies to 1.95 eV and harmonic frequencies to 296.0 cm−1 for X 1Γg and 297.0 cm−1 for 1 1Σg+. These values are in good agreement with experimental values of Re = 2.1545 ± 0.0004 Å, ωe = 280 ± 20 cm−1, and D0 = 2.042 ± 0.002 eV for the ground state. All states considered within the 3F4 + 3F4 dissociation channel proved to be energetically high-lying and van der Waals-like in nature. In contrast to most previous theoretical studies of Ni2, full PECs of all considered electronic states of the molecule were produced.
Effect of Uric Acid-Lowering Agents on Patients With Heart Failure: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Authors: Xu Hongxuan , Liu Yunqing , Meng Lingbing , Wang Li , Liu Deping 
Published: May 2021

Background: Elevated serum uric acid (SUA) level is considered an independent predictor of all-cause mortality and the combined endpoint of death or readmission in cardiovascular disease patients. However, the causal relationship between uric acid-lowering therapies (ULTs) and heart failure is still controversial.Design: Meta-analyses were performed to systematically compile available evidence to determine the overall effect of ULTs on heart failure patients.Method: We conducted this systematic review following the PRISMA statement guidelines. Databases were searched to identify randomised controlled trials related to the influence of a ULT intervention in people with heart failure. Data extracted from the included studies were subjected to a meta-analysis to compare the effects of ULTs to a control.Results: Pooled analysis of left ventricular ejection fraction (LEVF) showed an insignificant result towards the ULT group (MD, 1.63%; 95%CI, −1.61 to 4.88; p = 0.32; three studies). Pooled analysis of the 6-Minute Walk Test (6MWT) showed an insignificant result towards the ULT group (MD, 4.59; 95%CI, −12.683 to 22.00; p = 0.61; four studies). Pooled analysis of BNP/NT-pro-BNP led to a nearly statistically significant result towards the ULT group (SMD, −0.30; 95%CI, −0.64 to 0.04; p = 0.08; five studies). Pooled analysis of all-cause mortality and cardiovascular death between ULTs (all XOIs) and placebo did not show a significant difference (RR, 1.26; 95% CI, 0.74 to 2.15, p = 0.39).Conclusion: ULTs did not improve LVEF, BNP/NT-pro-BNP, 6MWT, all-cause mortality, and CV death in heart failure patients. UA may just be a risk marker of heart failure.
Role of Cardiovascular Computed Tomography in Acute Coronary Syndromes During the COVID-19 Pandemic-Single Center Snapshot Study
Authors: Alasnag Mirvat , Ahmed Waqar , Al-Nasser Ibrahim , Al-Shaibi Khaled 
Published: May 2021

Background: In clinical practice, cardiac computed tomography (CCT) has a limited role in acute coronary syndromes (ACS). Several trials evaluated CCT in low and intermediate risk patients presenting to the emergency room (ER) and noted that it was both safe and feasible. During the COVID19 pandemic, it is imperative to adopt a pathway for the evaluation of ACS that permits early discharge, reduces invasive coronary angiography and limits exposure of healthcare workers. Here, we present a single center experience by which CCT was incorporated in the clinical pathway of patients presenting to the ER with chest pain and ACS.Methods: This is a snapshot study of the first 27 patients who underwent CCT immediately after the lockdown in the city of Jeddah. ST elevation myocardial infarctions and hemodynamically unstable patients were excluded. Those with unstable angina or a Non-ST elevation myocardial infarction were screened for COVID19. The patients' COVID19 status and the results of the CCT were then used to determine the treatment strategy. Patient predisposition, hospital stay and exposure of staff are collected and reported.Results: All CCT images were interpretable with no limitations or significant artifact. CCT identified critical disease in 7 patients (26%), normal epicardial coronary arteries in 11 (41%) and mild to moderate disease in 9 (33%). All patients with normal or mild to moderate disease were assigned to a conservative strategy and discharged within 24 h. Those with a NSTEMI and critical anatomy were assigned to an additional invasive evaluation with subsequent revascularization. During the course of this study, no transmission to healthcare workers occurred.Conclusion: CCT enabled 80% of patients to be discharged within the first 24 h, the majority of whom were discharged from the emergency room. It was able to identify critical anatomy facilitating appropriate revascularization. This snapshot study warrants exploration of the role of CCT in ACS further particularly since the latest European Society of Cardiology's Non-STEACS guidelines suggest a role for CCT in the evaluation of low risk ACS.
Ensemble-Tailored Pattern Analysis of High-Resolution Dynamically Downscaled Precipitation Fields: Example for Climate Sensitive Regions of South America
Authors: Portele Tanja C. , Laux Patrick , Lorenz Christof , Janner Annelie , Horna Natalia , Fersch Benjamin , Iza Maylee , Kunstmann Harald 
Published: May 2021

For climate adaptation and risk mitigation, decision makers in water management or agriculture increasingly demand for regionalized weather and climate information. To provide these, regional atmospheric models, such as the Weather Research and Forecasting (WRF) model, need to be optimized in their physical setup to the region of interest. The objective of this study is to evaluate four cumulus physics (CU), two microphysics (MP), two planetary boundary layer physics (PBL), and two radiation physics (RA) schemes in WRF according to their performance in dynamically downscaling the precipitation over two typical South American regions: one orographically complex area in Ecuador/Peru (horizontal resolution up to 9 and 3 km), and one area of rolling hills in Northeast Brazil (up to 9 km). For this, an extensive ensemble of 32 simulations over two continuous years was conducted. Including the reference uncertainty of three high-resolution global datasets (CHIRPS, MSWEP, ERA5-Land), we show that different parameterization setups can produce up to four times the monthly reference precipitation. This underscores the urgent need to conduct parameterization sensitivity studies before weather forecasts or input for impact modeling can be produced. Contrarily to usual studies, we focus on distributional, temporal and spatial precipitation patterns and evaluate these in an ensemble-tailored approach. These ensemble characteristics such as ensemble Structure-, Amplitude-, and Location-error, allow us to generalize the impacts of combining one parameterization scheme with others. We find that varying the CU and RA schemes stronger affects the WRF performance than varying the MP or PBL schemes. This effect is even present in the convection-resolving 3-km-domain over Ecuador/Peru where CU schemes are only used in the parent domain of the one-way nesting approach. The G3D CU physics ensemble best represents the CHIRPS probability distribution in the 9-km-domains. However, spatial and temporal patterns of CHIRPS are best captured by Tiedtke or BMJ CU schemes. Ecuadorian station data in the 3-km-domain is best simulated by the ensemble whose parent domains use the KF CU scheme. Accounting for all evaluation metrics, no general-purpose setup could be identified, but suited parameterizations can be narrowed down according to final application needs.
Whole Blood Mycobacterial Growth Assays for Assessing Human Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis
Authors: Bok Jeroen , Hofland Regina W. , Evans Carlton A. 
Published: May 2021

BackgroundWhole blood mycobacterial growth assays (WBMGA) quantify mycobacterial growth in fresh blood samples and may have potential for assessing tuberculosis vaccines and identifying individuals at risk of tuberculosis. We evaluated the evidence for the underlying assumption thatin vitroWBMGA results can predictin vivotuberculosis susceptibility.MethodsA systematic search was done for studies assessing associations between WBMGA results and tuberculosis susceptibility. Meta-analyses were performed for eligible studies by calculating population-weighted averages.ResultsNo studies directly assessed whether WBMGA results predicted tuberculosis susceptibility. 15 studies assessed associations between WBMGA results and proven correlates of tuberculosis susceptibility, which we divided in two categories. Firstly, WBMGA associations with factors believed to reduce tuberculosis susceptibility were statistically significant in all eight studies of: BCG vaccination; vitamin D supplementation; altitude; and HIV-negativity/therapy. Secondly, WBMGA associations with probable correlates of tuberculosis susceptibility were statistically significant in three studies of tuberculosis disease, in a parasitism study and in two of the five studies of latent tuberculosis infection. Meta-analyses for associations between WBMGA results and BCG vaccination, tuberculosis infection, tuberculosis disease and HIV infection revealed consistent effects. There was considerable methodological heterogeneity.ConclusionsThe study results generally showed significant associations between WBMGA results and correlates of tuberculosis susceptibility. However, no study directly assessed whether WBMGA results predicted actual susceptibility to tuberculosis infection or disease. We recommend optimization and standardization of WBMGA methodology and prospective studies to determine whether WBMGA predict susceptibility to tuberculosis disease.
Silencing of circRNA circ_0001666 Represses EMT in Pancreatic Cancer Through Upregulating miR-1251 and Downregulating SOX4
Authors: Zhang Rundong , Zhu Wanli , Ma Chenchao , Ai Kaixing 
Published: May 2021

BackgroundPancreatic cancer (PC) is an aggressive malignancy and has a poor prognosis. Although emerging research has revealed that circular RNAs (circRNAs) are crucial modulators that control tumor development and metastasis, their functional involvement in PC has not been well characterized. Here, we examined whether and how circRNA circ_0001666 governs epithelial-mesenchymal transition (EMT) in PC.MethodsWe investigated the effects of circ_0001666 on EMT and PC cell invasion by gain- and loss-of-function assays. We also explored the mechanisms underlying the functions of circ_0001666 in PC cells.ResultsWe found that circ_0001666 is highly expressed in PC tissues and PC cell lines. Patients with high circ_0001666 expression had shorter survival times. In vitro and in vivo experiments have demonstrated that upregulation of circ_0001666 facilitates PC cell proliferation, EMT and invasiveness, whereas knockdown of circ_0001666 exhibits opposite functions. Moreover, circ_0001666 is able to bind to miR-1251, thus increasing the expression of SOX4, which is a direct downstream effector of miR-1251. The oncogenic effects of circ_0001666 on EMT and PC cell invasion were rescued by miR-1251 overexpression.ConclusionsThese results suggested that circ_0001666 acts as an oncogenic circRNA to promote EMT and invasion of PC cells through sponging miR-1251, and indicated that circ_0001666 could be explored as a potential therapeutic target for PC.
sTWEAK as Predictor of Stroke Recurrence in Ischemic Stroke Patients Treated With Reperfusion Therapies
Authors: Hervella Pablo , Pérez-Mato María , Rodríguez-Yáñez Manuel , López-Dequidt Iria , Pumar José M. , Sobrino Tomás , Campos Francisco , Castillo José , da Silva-Candal Andrés , Iglesias-Rey Ramón 
Published: May 2021

Aim: The purpose of this study was to investigate clinical and neuroimaging factors associated with stroke recurrence in reperfused ischemic stroke patients, as well as the influence of specific biomarkers of inflammation and endothelial dysfunction.Methods: We conducted a retrospective analysis on a prospectively registered database. Of the 875 patients eligible for this study (53.9% males; mean age 69.6 ± 11.8 years vs. 46.1% females; mean age 74.9 ± 12.6 years), 710 underwent systemic thrombolysis, 87 thrombectomy and in 78, systemic or intra-arterial thrombolysis together with thrombectomy was applied. Plasma levels of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFα) were analyzed as markers of inflammation, and soluble tumor necrosis factor-like inducer of apoptosis (sTWEAK) as an endothelial dysfunction marker. The main outcome variables of the study were the presence and severity of leukoaraiosis (LA) and stroke recurrence.Results: The average follow-up time of the study was 25 ± 13 months, during which 127 patients (14.5%) showed stroke recurrence. The presence and severity of LA was more severe in the second stroke episode (Grade III of the Fazekas 28.3 vs. 52.8%; p &lt; 0.0001). IL-6 levels at the first admission and before reperfusion treatment in patients with and without subsequent recurrence were similar (9.9 ± 10.4 vs. 9.1 ± 7.0 pg/mL, p = 0.439), but different for TNFα (14.7 ± 5.6 vs. 15.9 ± 5.7 pg/mL, p = 0.031) and sTWEAK (5,970.8 ± 4,330.4 vs. 8,660.7 ± 5,119.0 pg/mL, p &lt; 0.0001). sTWEAK values ≥7,000 pg/mL determined in the first stroke were independently associated to recurrence (OR 2.79; CI 95%: 1.87–4.16, p &lt; 0.0001).Conclusions: The severity and the progression of LA are the main neuroimaging factors associated with stroke recurrence. Likewise, sTWEAK levels were independently associated to stroke recurrence, so further studies are necessary to investigate sTWEAK as a therapeutic target.
Pembrolizumab-Induced Isolated Cranial Neuropathy: A Rare Case Report and Review of Literature
Authors: Bruno Francesco , Palmiero Rosa Antonietta , Ferrero Bruno , Franchino Federica , Pellerino Alessia , Milanesi Enrica , Soffietti Riccardo , Rudà Roberta 
Published: May 2021

Introduction: Anti-PD1 agents are widely used in the treatment of solid tumors. This has prompted the recognition of a class of immune-related adverse events (irAEs), due to the activation of autoimmune T-cells. Pembrolizumab is an anti-PD1 agent, which has been related to an increased risk of various neurological irAE (n-irAEs). Here, we present a rare case of pembrolizumab-induced neuropathy of cranial nerves.Case Report: A 72-year-old patient was diagnosed with a lung adenocarcinoma in February 2018 (EGFR–, ALK–, and PDL1 90%). According to the molecular profile, pembrolizumab was started. After three administrations, the patient developed facial paresis, ptosis, ophthalmoplegia, and dysphonia. As brain metastases and paraneoplastic markers were excluded, a drug-related disorder was suspected and pembrolizumab was discontinued. A nerve conduction study and electromyography excluded signs of neuropathy and myopathy at four limbs, and repetitive nerve stimulation was negative. However, altered blink reflex and nerve facial conduction were consistent with an acute neuropathy of the cranial district. Thus, the patient was treated with two cycles of intravenous immunoglobulins (IVIg), which rapidly allowed improvement of both symptoms and neurophysiological parameters. However, the patient died in October 2018 for a progression of lung tumor.Discussion: Only 16 cases of pembrolizumab-related neuropathies have been described so far. Our case is of particular interest for the isolated involvement of cranial nerves and the prompt response to IVIg.Conclusion: N-irAEs are insidious conditions that require solid knowledge of onco-immunotherapy complications: it is mandatory not to delay any treatment that would potentially modify the course of a neurological complication.
Automated Analysis of Risk Factors for Postictal Generalized EEG Suppression
Authors: Zhao Xiuhe , Vilella Laura , Zhu Liang , Rani M. R. Sandhya , Hampson Johnson P. , Hampson Jaison , Hupp Norma J. , Sainju Rup K. , Friedman Daniel , Nei Maromi , Scott Catherine , Allen Luke , Gehlbach Brian K. , Schuele Stephan , Harper Ronald M. , Diehl Beate , Bateman Lisa M. , Devinsky Orrin , Richerson George B. , Zhang Guo-Qiang , Lhatoo Samden D. , Lacuey Nuria 
Published: May 2021

Rationale: Currently, there is some ambiguity over the role of postictal generalized electro-encephalographic suppression (PGES) as a biomarker in sudden unexpected death in epilepsy (SUDEP). Visual analysis of PGES, known to be subjective, may account for this. In this study, we set out to perform an analysis of PGES presence and duration using a validated signal processing tool, specifically to examine the association between PGES and seizure features previously reported to be associated with visually analyzed PGES.Methods: This is a prospective, multicenter epilepsy monitoring study of autonomic and breathing biomarkers of SUDEP in adult patients with intractable epilepsy. We studied videoelectroencephalogram (vEEG) recordings of generalized convulsive seizures (GCS) in a cohort of patients in whom respiratory and vEEG recording were carried out during the evaluation in the epilepsy monitoring unit. A validated automated EEG suppression detection tool was used to determine presence and duration of PGES.Results: We studied 148 GCS in 87 patients. PGES occurred in 106/148 (71.6%) seizures in 70/87 (80.5%) of patients. PGES mean duration was 38.7 ± 23.7 (37; 1–169) seconds. Presence of tonic phase during GCS, including decerebration, decortication and hemi-decerebration, were 8.29 (CI 2.6–26.39, p = 0.0003), 7.17 (CI 1.29–39.76, p = 0.02), and 4.77 (CI 1.25–18.20, p = 0.02) times more likely to have PGES, respectively. In addition, presence of decerebration (p = 0.004) and decortication (p = 0.02), older age (p = 0.009), and hypoxemia duration (p = 0.03) were associated with longer PGES durations.Conclusions: In this study, we confirmed observations made with visual analysis, that presence of tonic phase during GCS, longer hypoxemia, and older age are reliably associated with PGES. We found that of the different types of tonic phase posturing, decerebration has the strongest association with PGES, followed by decortication, followed by hemi-decerebration. This suggests that these factors are likely indicative of seizure severity and may or may not be associated with SUDEP. An automated signal processing tool enables objective metrics, and may resolve apparent ambiguities in the role of PGES in SUDEP and seizure severity studies.