bluuebunny/crossref_metadata_2025_split huggingface dataset:
Business orientation and sustainable development: A systematic review of sustainability orientation literature and future research avenues
Authors: Khizar Hafiz Muhammad Usman , Iqbal Muhammad Jawad , Rasheed Muhammad Imran 
Published: April 2021

AbstractThis study aims to systematically identify, review, and assess the progression of sustainability orientation literature and provide an agenda for future research. We employed a systematic literature review (SLR) technique to select a sample of 93 studies from five databases: Web of Sciences, Scopus, Science Direct, Wiley Online Library, and Emerald Insight. The content analysis, aided by MaxQDA, was utilized for review and analysis purposes. The findings suggest that extant research on sustainability orientation can be categorized into six key themes: drivers of sustainability orientation, consequences/outcomes of sustainability orientation, multiple strategic orientations paradigm, elements of sustainability orientation, and crowdfunding. The current study critically evaluates the existing scholarship on the topic, reveals the limitations and knowledge gaps in the current body of literature, and suggests potential avenues for further advancement of knowledge in this area. Our study offers key implications for theory and practice.
Artificial Neuron and Synapse Devices Based on 2D Materials
Authors: Lee Geonyeop , Baek Ji‐Hwan , Ren Fan , Pearton Stephen J. , Lee Gwan‐Hyoung , Kim Jihyun 
Published: April 2021

AbstractNeuromorphic systems, which emulate neural functionalities of a human brain, are considered to be an attractive next‐generation computing approach, with advantages of high energy efficiency and fast computing speed. After these neuromorphic systems are proposed, it is demonstrated that artificial synapses and neurons can mimic neural functions of biological synapses and neurons. However, since the neuromorphic functionalities are highly related to the surface properties of materials, bulk material‐based neuromorphic devices suffer from uncontrollable defects at surfaces and strong scattering caused by dangling bonds. Therefore, 2D materials which have dangling‐bond‐free surfaces and excellent crystallinity have emerged as promising candidates for neuromorphic computing hardware. First, the fundamental synaptic behavior is reviewed, such as synaptic plasticity and learning rule, and requirements of artificial synapses to emulate biological synapses. In addition, an overview of recent advances on 2D materials‐based synaptic devices is summarized by categorizing these into various working principles of artificial synapses. Second, the compulsory behavior and requirements of artificial neurons such as the all‐or‐nothing law and refractory periods to simulate a spike neural network are described, and the implementation of 2D materials‐based artificial neurons to date is reviewed. Finally, future challenges and outlooks of 2D materials‐based neuromorphic devices are discussed.
Interleaved Parallel High Step‐upDC‐DCConverter withCross‐CoupledInductors for Low Current/Voltage Ripple andAuto‐CurrentSharing
Authors: He Liangzong , Zeng Tao 
Published: April 2021

AbstractAn interleaved parallel high step‐up DC‐DC converter with cross‐coupled inductors for low current/voltage ripple and auto‐current sharing was proposed in this paper. This converter applies interleaved parallel input which decreases the input current ripple significantly. Due to the interleaved coupling effect of three coils of the cross‐coupled inductors, this converter can realize automatic current sharing under asymmetric distribution of duty ratio of switch control signal or coupled inductors. By using the leakage inductance of coupled inductors, the proposed DC‐DC converter has high voltage gains and small voltage stress of the main switches and output diodes. Moreover, the proposed converter solves the reverse recovery problem of the output diodes at the minimum loss. In addition, its power switches realize zero‐current turn on. In this paper, working principle is analyzed thoroughly and performance of this topological circuit is verified through a prototype with 1 kW output. © 2021 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
Prospective evaluation of first‐trimester screening strategy for preterm pre‐eclampsia and its clinical applicability in China
Authors: Hu J. , Gao J. , Liu J. , Meng H. , Hao N. , Song Y. , Ma L. , Luo W. , Sun J. , Gao W. , Meng W. , Sun Y. 
Published: April 2021

ABSTRACTObjectivesTo evaluate, in a Chinese population, the performance of a screening strategy for preterm pre‐eclampsia (PE) using The Fetal Medicine Foundation (FMF)'s competing‐risks model and to explore its clinical applicability in mainland China.MethodsThis was a prospective, multicenter, observational cohort study including 10 899 women with singleton pregnancy who sought prenatal care at one of 13 hospitals, located in seven cities in mainland China, between 1 December 2017 and 30 December 2019. Mean arterial pressure (MAP), uterine artery pulsatility index (UtA‐PI) and maternal serum levels of placental growth factor (PlGF) and pregnancy‐associated plasma protein‐A (PAPP‐A) at 11 + 0 to 13 + 6 weeks’ gestation were measured and converted into multiples of the median using Chinese reference ranges. Individualized risk for preterm PE was calculated using the FMF algorithm. Prior risk was calculated based on maternal demographic characteristics and obstetric history. We evaluated the efficiency of the screening strategy using various combinations of biomarkers and analyzed its predictive performance for a composite of placenta‐associated adverse pregnancy outcomes, including PE, placental abruption, small‐for‐gestational age (SGA) and preterm birth, at fixed false‐positive rates for preterm PE.ResultsWe identified 312 pregnancies that developed PE, of which 117 cases were diagnosed as preterm PE (< 37 weeks' gestation). There were 386 pregnancies complicated by severe composite placenta‐associated adverse outcome, including preterm PE, 146 cases of severe SGA (birth weight < 3rd percentile) neonate, 61 cases with placental abruption and 109 cases of early preterm birth < 34 gestational weeks. The triple‐marker model containing biomarkers MAP, UtA‐PI and PAPP‐A achieved, at fixed false‐positive rates of 10%, 15% and 20%, detection rates for preterm PE of 65.0%, 72.7% and 76.1%, respectively, and detection rates for severe composite placenta‐associated adverse outcome of 34.7%, 41.7% and 46.4%, respectively. Replacing PAPP‐A with PlGF or adding PlGF to the model did not improve the performance. Of women screening positive for preterm PE at a fixed 5% false‐positive rate, an estimated 30% developed at least one placenta‐associated adverse pregnancy outcome, including PE, placental abruption, SGA (birth weight < 10th percentile) and preterm birth < 37 weeks.ConclusionsThe FMF competing‐risks model for preterm PE was found to be effective in screening a mainland Chinese population. Women who screened positive for preterm PE had increased risk for other placenta‐associated pregnancy complications. © 2021 International Society of Ultrasound in Obstetrics and Gynecology.
Prevalence and distribution of Anaplasma phagocytophilum in ticks collected from dogs in the United Kingdom
Authors: Keyte Sophie , Abdullah Swaid , James Kate , Newbury Hannah , Helps Chris , Tasker Séverine , Wall Richard 
Published: April 2021

AbstractBackground: Anaplasma phagocytophilum is the etiological agent of canine granulocytic anaplasmosis in dogs and causes human granulocytic anaplasmosis (HGA). Tick‐borne anaplasmosis has been recognised as an emerging zoonotic health concern worldwide. The aim of the present study was to determine the prevalence of A. phagocytophilum in ticks collected from dogs in the UK and map its distribution. Routine surveillance of tick‐borne disease is essential as part of a “One Health” approach to infectious disease management.Methods: Tick DNA samples collected in 2015 as part of a large‐scale tick surveillance programme were analysed using a previously validated diagnostic quantitative PCR for A. phagocytophilum.Results: PCR analysis indicated that 138 out of 2994 tick DNA samples analysed were positive for A. phagocytophilum, a prevalence of 4.6% (95% CI: 3.89–5.42). Among these 138 tick DNA samples, 131 were from Ixodes ricinus, six were from Ixodes hexagonus and one was from Ixodes canisuga. Three of the I. ricinus tick DNA samples positive for A. phagocytophilum DNA were also positive for Borrelia spp. DNA and one was positive for Babesia spp. DNA, indicating co‐infection. The ticks positive for the pathogen DNA were found widely distributed throughout the UK.Conclusions: These data provide important information on the prevalence and wide distribution of A. phagocytophilum in ticks infesting dogs within the UK.
Hafnia alvei: The unreported pathogen responsible for a sub‐capsular renal abscess in a 1‐year‐old, presumed immunocompetent crossbreed dog with no co‐morbidities
Authors: Petchell William H. R. , Noble P‐J. M. , Burrow Rachel , Humphreys William J. E. , Bautista Díaz‐Delgado Oscar 
Published: April 2021

AbstractA 12‐month‐old, male neutered Rottweiler cross, weighing 34.0 kg with a 6‐month history of episodes of pyrexia, hyporexia, pollakiuria and left flank pain is described. Ultrasonographic and computed tomography findings combined with clinical signs were consistent with a left renal abscess which was treated 2 days later with a left ureteronephrectomy. Septic peritonitis was assumed intraoperatively upon the discovery of a moderate amount of turbid, straw‐coloured free abdominal fluid and the appearance of the abdominal organs and peritoneum. Histopathology of the kidney confirmed a focally extensive subcapsular renal abscess with concurrent suppurative and lymphoplasmacellular nephritis. Culture of the intra‐capsular fluid and of the renal tissue resulted in heavy growths of Hafnia alvei. The dog spent 8 days in the hospital and made a full recovery; resolution of the presenting signs has been achieved to date. A good prognosis is given cautiously owing to the undetermined aetiology of disease.
Multiple endocrine neoplasia type 2‐like syndrome in a crossbred dog
Authors: Cervone Mario , Blondel Margaux , Moissonnier Pierre , Chabanne Luc 
Published: April 2021

AbstractA 9‐year‐old spayed female crossbred dog was referred with a 6‐month history of polyuria/polydipsia associated with systemic arterial hypertension and hypokalaemia according to clinical and biochemical evaluations, respectively. Pheochromocytoma with concomitant unilateral nonsecreting thyroid carcinoma and ipsilateral nonsecreting parathyroid hyperplasia were diagnosed by ultrasonography, computed tomography, cytology and histopathology. Surgical treatment allowed for the complete resolution of clinical and biochemical abnormalities, and no recurrence was found during the one‐year clinical follow‐up. To the best of the author's knowledge, this is the third report describing multiple endocrine neoplasia type 2‐like syndrome in dogs, and it further characterizes this rare condition.
Gastro‐oesophageal resection and anastomosis for an oesophageal leiomyoma in a dog
Authors: Chen Carolyn , Cook Matthew , Lumbrezer‐Johnson Sarah , Hostnik Eric , Selmic Laura E. 
Published: April 2021

AbstractAn 11‐year‐old female spayed golden retriever was presented for a second opinion regarding a recently diagnosed distal oesophageal mass. The dog had a history of chronic post‐prandial regurgitation. Physical examination and laboratory work yielded no significant findings. Thoracic radiographs revealed no significant findings other than equivocal cardiomegaly. A fluoroscopic barium swallow study and computed tomography scans of the chest and abdomen were performed, revealing an approximately 2.5 cm mass at the level of the lower oesophageal sphincter. A gastro‐oesophageal resection and anastomosis was performed and histopathology of the mass was consistent with leiomyoma, excised with complete margins. The dog recovered uneventfully and was discharged from the hospital 3 days after surgery. The dog was doing well 5 months after surgery, with an acceptable quality of life and mild, intermittent regurgitation episodes.
Sparsifying to optimize over multiple information sources: an augmented Gaussian process based algorithm
Authors: Candelieri Antonio , Archetti Francesco 
Published: April 2021

AbstractOptimizing a black-box, expensive, and multi-extremal function, given multiple approximations, is a challenging task known as multi-information source optimization (MISO), where each source has a different cost and the level of approximation (akafidelity) of each source can change over the search space. While most of the current approachesfusethe Gaussian processes (GPs) modelling each source, we propose to use GPsparsificationto select only “reliable” function evaluations performed over all the sources. These selected evaluations are used to create an augmented Gaussian process (AGP), whose name is implied by the fact that the evaluations on the most expensive source areaugmentedwith the reliable evaluations over less expensive sources. A new acquisition function, based on confidence bound, is also proposed, including both cost of the next source to query and the location-dependent approximation of that source. This approximation is estimated through amodel discrepancymeasure and the prediction uncertainty of the GPs. MISO-AGP and the MISO-fused GP counterpart are compared on two test problems and hyperparameter optimization of a machine learning classifier on a large dataset.
Detecting Hospital Outliers in Post‐Pancreatectomy Care Using Funnel Plots from 2009–2018 Based on Nationwide Medico‐Administrative Data
Authors: Bernard Alain , Cottenet Jonathan , Aho Serge , Doussot Alexandre , Mariet Anne‐Sophie , Facy Olivier , Quantin Catherine 
Published: April 2021

AbstractObjectivesOur objective was to identify hospitals with unusual mortality rates for major pancreatectomies over a period of ten years using 30‐day mortality data from the French national database.MethodsData for all patients who underwent pancreatectomy were extracted from the national medico‐economic database (Programme de Médicalisation des Systèmes d'Information). To identify quality outliers for each hospital, the observed‐to‐expected 30‐day mortality rates were used as a quality indicator.ResultsA total of 19 494 patients underwent a major pancreatectomy in France between January 2009 and December 2018. The overall 30‐day mortality rate was 4.8% (n = 944). For the 2009–2014 period, the funnel plot showed that 10 of the 176 hospitals lie outside the central 95% region and 7 lie outside the central 99.8% region. For the 2015–2018 period, out of 176 hospitals, 6 lie outside the central 95% region and 2 lie outside the central 99.8% region. The change in standardized mortality ratios between 2009–2014 and 2015–2018 testing for differences from the overall change, they were there 4 hospitals lie outside the central 95% region and 0 lie outside the central 99.8% region.ConclusionOver time, the improvement in hospital quality was weak. This study suggests that there is a pressing need to reorganize the supply of care for pancreatic surgery in France.
Misleading terminology in pathology: lack of definitions hampers communication
Authors: Chow Zi Long , Indave Blanca Iciar , Lokuhetty Menaka Dilani Samarawickrema , Ochiai Atsushi , Cree Ian A. , White Valerie A. 
Published: April 2021

AbstractAccurate terminology is the basis for clear communication among specialists and relies upon precise definitions, indispensable for the WHO Classification of Tumours. We identified a number of potentially misleading terms in use in the recently published WHO Classification of Tumours, 5th edition. From a list of common sources that might be consulted by specialists in the pathology field, we searched for definitions of the terms. Where at least two sources provided definitions for a term, we assessed their level of agreement using an ad hoc developed scale. We identified 26 potentially misleading terms from the 5th edition Digestive System and Breast Tumour Books, and 16 sources. The number of definitions provided by the sources ranged from no definition (for four terms) to ten (for two terms). No source had definitions for all terms. We found only 111 (27%) of a possible 416 definitions. Where two or more definitions were present for a term, the level of agreement between them was judged to be high. There was a paucity of definitions for potentially misleading terms in the sources consulted, but there was a good agreement when two or more definitions were present. In a globalized world where healthcare workers and learners in many fields may access these sources to learn about terminology with which they are unfamiliar, the lack of definitions is a hindrance to a precise understanding of classification in the speciality of pathology and to clear communication between specialist groups.
Provocation and prediction of visual peripersonal neglect-like symptoms in preoperative planning and during awake brain surgery
Authors: Tamás Viktória , Sebestyén Gabriella , Nagy Szilvia Anett , Horváth Péter Zsolt , Mérei Ákos , Tomaiuolo Francesco , Raffa Giovanni , Germanó Antonino Francesco , Büki András 
Published: April 2021

AbstractNeglect is a severe neuropsychological/neurological deficit that usually develops due to lesions of the posterior inferior parietal area of the right hemisphere and is characterized by a lack of attention to the left side. Our case is a proven right-handed, 30-year-old female patient with a low-grade glioma, which was located in the temporo-opercular region and also in the superior temporal gyrus of the right hemisphere. Upon presurgical planning, the motor, language, and visuospatial functions were mapped. In order to achieve this, the protocol for routine magnetic resonance imaging and navigated transcranial magnetic stimulation has been expanded, accordingly.
Exosomes secreted from sonic hedgehog-modified bone mesenchymal stem cells facilitate the repair of rat spinal cord injuries
Authors: Jia Yijia , Lu Tingsheng , Chen Qiling , Pu Xingwei , Ji Linsong , Yang Jianwen , Luo Chunshan 
Published: April 2021

Abstract
Background
Spinal cord injuries (SCIs) can cause a loss of neurons and associated sensory and motor functionality below the injured site. No approaches to treating SCIs in humans have been developed to date. Exosomes are extracellular vesicles that hold promise as a potential therapeutic modality when treating such injuries. The present study was thus designed to determine whether sonic hedgehog (Shh)-overexpressing bone mesenchymal stem cell (BMSC)-derived exosomes were protective in the context of SCIs.

Methods
Exosomes were extracted from control or Shh lentivirus-transduced BMSCs, yielding respective BMSC-Exo and BMSC-Shh-Exo preparations which were intravenously injected into SCI model rats. Shh expression in spinal cord tissues in these animals was then assessed via immunohistochemical staining, while Basso-Beattie-Bresnahan (BBB) scores were utilized to measure high limb motor function. Neuronal damage and regeneration within the spinal cord were additionally evaluated via terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL), Nissl, hematoxylin and eosin, and immunofluorescent staining.

Results
Both BMSC-Exo and BMSC-Shh-Exo preparations significantly increased Shh expression in the spinal cord of SCI model rats and improved BBB scores in these treated animals, while also increasing the frequencies of Nissl- and NeuN-positive neurons are reducing the numbers of apoptotic and GFAP-positive neurons. While both treatments yielded some degree of benefit to treated animals relative to untreated controls, BMSC-Shh-Exos were more beneficial than were control BMSC-Exos.

Conclusions
Shh-overexpressing BMSC-derived exosomes represent an effective treatment that can facilitate SCI repair in rats.
Two novel missense variants in SPTBN2 likely associated with spinocerebellar ataxia type 5
Authors: Bian Xianli , Wang Shang , Jin Suqin , Xu Shunliang , Zhang Hong , Wang Dewei , Shang Wei , Wang Ping 
Published: April 2021

Abstract
Introduction
Spinocerebellar ataxias (SCAs) are a heterozygous group of neurodegenerative disorders. Spinocerebellar ataxia type 5 (SCA5) is a rare autosomal-dominant ataxia with pure cerebellum involvement. The clinical characteristics are limb and gait ataxia, trunk ataxia, sensory deficits, abnormal eye movement, dysarthria, and hyperactive tendon reflexes. Spectrin beta nonerythrocytic 2 gene (SPTBN2), coding β-III spectrin protein, was identified to be associated with SCA5. To date, more than 19 variants of SPTBN2 have been reported.

Methods
A family and an apparently sporadic patient with ataxia and cerebellar atrophy were recruited from Shandong Province (China). To discover the disease-causing variants, capillary electrophoresis and targeted next-generation sequencing were performed in the proband of the family and the sporadic patient. The candidate variants were verified by Sanger sequencing and analyzed by bioinformatics software.

Results
In our study, we verified two novel heterozygous variants in SPTBN2 in a SCA pedigree and a sporadic patient. The proband of the pedigree and her mother presented with walking instability and progressively getting worse. The sporadic patient suffered from slurred speech, walking instability, and drinking water choking cough. MRI examination of the proband and sporadic patient both displayed moderate cerebellar atrophy. The variants identified were traditionally conserved and predicted probably damaging and disease-causing by bioinformatics analysis.

Conclusion
We identified two novel heterozygous variants of SPTBN2 resulting in severe ataxia which further delineated the correlation between the genotype and phenotype of SCA5, and pathogenesis of variants in SPTBN2 should be further researched.
Developmental stochasticity and variation in floral phyllotaxis
Authors: Kitazawa Miho S. 
Published: April 2021

AbstractFloral phyllotaxis is a relatively robust phenotype; trimerous and pentamerous arrangements are widely observed in monocots and core eudicots. Conversely, it also shows variability in some angiosperm clades such as ‘ANA’ grade (Amborellales, Nymphaeales, and Austrobaileyales), magnoliids, and Ranunculales. Regardless of the phylogenetic relationship, however, phyllotactic pattern formation appears to be a common process. What are the causes of the variability in floral phyllotaxis and how has the variation of floral phyllotaxis contributed to floral diversity? In this review, I summarize recent progress in studies on two related fields to develop answers to these questions. First, it is known that molecular and cellular stochasticity are inevitably found in biological systems, including plant development. Organisms deal with molecular stochasticity in several ways, such as dampening noise through gene networks or maintaining function through cellular redundancy. Recent studies on molecular and cellular stochasticity suggest that stochasticity is not always detrimental to plants and that it is also essential in development. Second, studies on vegetative and inflorescence phyllotaxis have shown that plants often exhibit variability and flexibility in phenotypes. Three types of phyllotaxis variations are observed, namely, fluctuation around the mean, transition between regular patterns, and a transient irregular organ arrangement called permutation. Computer models have demonstrated that stochasticity in the phyllotactic pattern formation plays a role in pattern transitions and irregularities. Variations are also found in the number and positioning of floral organs, although it is not known whether such variations provide any functional advantages. Two ways of diversification may be involved in angiosperm floral evolution: precise regulation of organ position and identity that leads to further specialization of organs and organ redundancy that leads to flexibility in floral phyllotaxis.