bluuebunny/crossref_metadata_2025_split huggingface dataset:
Refractive changes with post-rotatory nystagmus in healthy individuals
Authors: Hirota Masakazu , Takigawa Ryusei , Okabe Chinatsu , Kato Kanako , Nakagomi Ryota , Sasaki Kakeru , Hayashi Takao 
Published: July 2021

Abstract
Purpose Post-rotatory nystagmus has been used to detect autism spectrum disorders in clinical settings. Although previous studies have focused on eye movements, they did not evaluate the change in ocular refraction during post-rotatory nystagmus. This study aimed to evaluate the changes in ocular refraction during post-rotatory nystagmus in healthy individuals. Methods A total of 34 healthy volunteers (mean age ± standard deviation, 20.9 ± 0.6 years) participated in this study. The ocular refraction during post-rotatory nystagmus was measured using MR-6000 (Tomey Inc.) on quick mode with a sampling rate of 30 Hz under noncycloplegic and cycloplegic conditions. The amplitude of post-rotatory nystagmus was calculated on the basis of the anterior eye images, while the ocular refraction measurements were simultaneously recorded. The accommodative convergence per accommodation ratio was calculated using the heterophoria method. Video oculography was performed to measure the angle of convergence during post-rotatory nystagmus. Results The changes in ocular refraction during post-rotatory nystagmus were significantly greater under the noncycloplegic condition than under the cycloplegic condition. The changes in ocular refraction during the post-rotatory nystagmus were significantly and positively correlated with the amplitude of post-rotatory nystagmus under the noncycloplegic condition. The angle of convergence during post-rotatory nystagmus was significantly higher under the noncycloplegic condition than under the cycloplegic condition. The changes in the angle of convergence were significantly and positively correlated with the predicted accommodative convergence. Conclusions These findings suggest that the accommodation was functional during the post-rotatory nystagmus to compensate for the retinal image slip, and the accommodative convergence can help weaken the nystagmus.
Novel Chloroflexi Genomes From The Deepest Ocean Reveal Metabolic Strategies For The Adaptation To Deep-Sea Habitats
Authors: Liu Rulong , Wei Xing , Wang Li , Cao Junwei , Song Weizhi , Wu Jiaxin , Thomas Torsten , Jin Tao , Wang Zixuan , Wei Wenxia , Wei Yuli , Zhai Haofeng , Yao Cheng , Shen Ziyi , Fang Jiasong 
Published: July 2021

Abstract
Background: The deep-sea harbors the majority of the microbial biomass in the Ocean, and it is a key site for organic matter (OM) remineralization and storage in the biosphere. Microbial metabolism in the deep ocean is greatly controlled by the generally depleted but periodically fluctuating supply of OM. Currently, little is known about metabolic potentials of dominant deep-sea microbes to cope with the variable OM inputs, especially for those living in the hadal trenches - the deepest part of the ocean. Results: In this study, we report the first extensive examination of the metabolic potentials of hadal sediment Chloroflexi, a dominant phylum in hadal trenches and the global deep ocean. Sixty-two metagenome-assembled-genomes (MAGs) were reconstructed from nine metagenomic datasets derived from sediments of the Mariana Trench. These MAGs represent six novel species, four novel genera, one novel family and one novel order within the classes Anaerolineae and Dehalococcoidia. Fragment recruitment showed that these MAGs are globally distributed in deep-sea waters and surface sediments, and transcriptomic analysis indicated their in-situ activities. Metabolic reconstruction showed that hadal Chloroflexi mainly had a heterotrophic lifestyle, with the potential to degrade a wide range of organic carbon, sulfur, and halogenated compounds. Our results revealed for the first time that hadal Chloroflexi harbor pathways for the complete hydrolytic or oxidative degradation of various recalcitrant OM, including aromatic compounds (e.g. benzoate), polyaromatic hydrocarbons (e.g. fluorene), polychlorobiphenyl (e.g. 4-chlorobiphenyl) and organochlorine compounds (e.g. chloroalkanes, chlorocyclohexane). Moreover, these organisms showed the potential to synthesize energy storage compounds (e.g. trehalose), and had regulatory modules to respond to changes in nutrient conditions. These metabolic traits lead us to postulate that the Chloroflexi may follow a “feast and famine” metabolic strategy, allowing them to efficiently consume labile OM and store the energy under OM rich conditions, and to survive under OM limitations by utilizing stored energy and degrading recalcitrant OM. Conclusion: This study expands the current knowledge on metabolic strategies in deep-ocean Chlorolfexi, and highlights their significance in deep-sea carbon, sulfur and halogen cycles. The metabolic plasticity likely provides Chloroflexi with advantages for the survival under variable and heterogenic OM inputs in the deep ocean.
Site-Controlled Telecom Single-Photon Emitters in Atomically-thin MoTe2
Authors: Zhao Huan , Pettes Micahel , Zheng Yu , Htoon Han 
Published: July 2021

Abstract
Quantum emitters (QEs) in two-dimensional transition metal dichalcogenides (2D TMDCs) have advanced to the forefront of quantum communication and transduction research1. To date, QEs capable of operating in O-C telecommunication bands have not been demonstrated in TMDCs.2-5 Here we report a deterministic creation of such telecom QEs emitting over the 1080 to 1550 nm wavelength range via coupling of 2D molybdenum ditelluride (MoTe2) to strain inducing nano-pillar arrays.6, 7 Our Hanbury Brown and Twiss experiment conducted at 10 K reveals clear photon antibunching with 90% single photon purity. The photon antibuching can be observed up to liquid nitrogen temperature (77 K). Polarization analysis further reveals that while some QEs display cross-linearly polarized doublets with ~1 meV splitting resulting from the strain induced anisotropic exchange interaction, valley degeneracy is preserved in other QEs. Valley Zeeman splitting as well as restoring of valley symmetry in cross-polarized doublets are observed under 8T magnetic field.
A Phase II Study of Sequential Treatment with Anthracycline and Taxane Followed by Eribulin in Patients with HER2-negative, Locally Advanced Breast Cancer (JBCRG-17)
Authors: Fukada Ippei , Ito Yoshinori , Kondo Naoto , Ohtani Shoichiro , Hattori Masaya , Tokunaga Eriko , Matusnami Nobuki , Mashino Kohjiro , Kosaka Taijiro , Tanabe Masahiko , Yotusmoto Daisuke , Yamanouchi Kosho , Sawaki Masataka , Kashiwaba Masahiro , Kawabata Hidetaka , Kuroi Katsumasa , Morita Satoshi , Ohno Shinji , Toi Masakazu , Masuda Norikazu 
Published: July 2021

Abstract
PurposeThe sequence of taxanes (T) followed by anthracyclines (A) as neoadjuvant chemotherapy (NAC) has been the standard of care for almost 20 years for locally advanced breast cancer (LABC). Sequential administration of eribulin (E) following A/T could provide a greater response rate for women with LABC.MethodsIn this single-arm, multicenter, Phase II prospective study, the patients received 4 cycles of the FEC regimen and 4 cycles of taxane. After the A/T-regimen, 4 cycles of E were administered followed by surgical resection. The primary endpoint was the clinical response rate. Eligible patients were women aged 20 years or older, with histologically confirmed invasive breast cancer, clinical Stage IIIA (T2-3 and N2 only), Stage IIIB, and Stage IIIC, HER2-negative.ResultsA preplanned interim analysis aimed to validate the trial assumptions was conducted after treatment of 20 patients and demonstrated that clinical progressive disease (cPD) rates in the E phase were significantly higher (30%) than assumed. Therefore, the Independent Data Monitoring Committee recommended stopping the study. Finally, 53 patients were enrolled, and 26 patients received the A/T/E-regimen. The overall observed clinical response rate (RR) was 73% (19/26); RRs were 77% (20/26) in the AT phase and 23% (6/26) in the E phase. Thirty percent (8/26) of patients had PD in the E phase, 6 of whom had achieved cCR/PR in the AT phase. Reported grade >3 AEs related to E were neutropenia (42%), white blood cell count decrease (27%), febrile neutropenia (7.6%), weight gain (3.8%), and weight loss (3.8%)ConclusionSequential administration of eribulin after the A/T-regimen provided no additional effect for LABC patients. Future research should continue to focus on identifying specific molecular biomarkers that can improve response rates.
A unified framework for three accelerated extragradient methods and further acceleration for variational inequality problems
Authors: Sahu D. R. 
Published: July 2021

Abstract
The main strategy of this paper is intended to speed up the convergence of the inertial Mann iterative method and further speed up it through the normal S-iterative method for a certain class of nonexpansive type operators that are linked with variational inequality problems. Our new convergence theory permits us to settle down the difficulty of unification of Korpelevich's extragradient method, Tseng's extragardient method, and subgardient extragardient method for solving variational inequality problems through an auxiliary algorithmic operator, which is associated with seed operator. The paper establishes an interesting fact that the relaxed inertial normal S-iterative extragradient methods do influence much more on convergence behaviour. Finally, the numerical experiments are carried out to illustrate that the relaxed inertial iterative methods, in particular the relaxed inertial normal S-iterative extragradient methods, may have a number of advantages over other methods in computing solutions of variational inequality problems in many cases.
Differential Second Primary Malignancy Occurrence After Breast Cancer According to HER2 Status: a SEER Population-Based Analysis
Authors: Lin Xiaoyi , Lin Xin , Wei Guangnan , Lin Jiali , Liao Ning , Zhang Guochun 
Published: July 2021

Abstract
Background: The survival improvement in breast cancer (BC) renders the long-termsurvivorsan increasedprobability of second primary malignancy (SPM), and thus excess mortality. Although previous evidence has indicated various predictorsofSPM, little is known whether SPM incidencevaries by HER2 status of first BC. Methods: Based on BC patients registered between 2010-2018 in the NCI SEER database, we utilized standardized incidence ratio (SIR) and Poisson regression to quantify SPM occurrence compared with the general population. Then, adjusted for competing death risk, cumulative incidence function and Gray’s test were adopted to estimate the probability of SPM. Subsequent proportional subdistribution hazards regression was executedto identify the HER2 status impact on SPM risk. Finally, survival analysiswas performed.Results: A total of 409,796 first BC patients were includedand 18,283 were identified with at least one SPM. The SIR of SPM after HER2+ BC was significantly lower than HER2- BC (1.03 vs 1.13; RR, 0.92; 95% CI, 0.88-0.96; p<0.001). But the predominantly declining SPM risk was only observed for second BC (RR, 0.89; 95% CI, 0.82-0.96; p=0.003) and lung and bronchus cancer (RR, 0.84; 95% CI, 0.74-0.95; p=0.007). Further competing risk analysis verified the protective effect of HER2 positivity status on SPM occurrence.The 5-year cumulative incidence of SPM following HER2+ and HER2- BC were 5.16% and 4.09%, respectively (p<0.001). In addition, among patients suffering from SPM,HER2 positivity status contributed tobetter overall survival. Conclusion: After considering intrinsic incremental risk with age and adjusting for competing risk of death, our study demonstrated that HER2+ BC patients had lower SPM occurrence, remarkable for second BC and lung and bronchus cancer. The disparity implies the relation between SPM occurrence and therapeutic along with genetic factors underlying BC HER2 status.
Turing-Hopf Bifurcation in the Predator-prey Model with Cross-diffusion Considering Two Different Prey Behaviours Transition
Authors: Lv Yehu 
Published: July 2021

Abstract
In this paper, we study the Turing-Hopf bifurcation in the predator-prey model with cross-diffusion considering the individual behaviour and herd behaviour transition of prey population subject to homogeneous Neumann boundary condition. Firstly, we study the non-negativity and boundedness of solutions corresponding to the temporal model, spatiotemporal model and the existence and priori boundedness of solutions corresponding to the spatiotemporal model without cross-diffusion. Then by analyzing the eigenvalues of characteristic equation associated with the linearized system at the positive constant equilibrium point, we investigate the stability and instability of the corresponding spatiotemporal model. Moreover, by computing and analyzing the normal form on the center manifold associated with the Turing-Hopf bifurcation, we investigate the dynamical classification near the Turing-Hopf bifurcation point in detail. At last, some numerical simulations results are given to support our analytic results.
Time-domain Feature and Ensemble Model based Classification of EMG Signals for Hand Gesture Recognition
Authors: Bhattacharjee Debarati , Singh Munesh 
Published: July 2021

Abstract
The electromyography (EMG) signal is the electrical current generated in muscles due to the inter-change of ions during their contractions. It has many applications in clinical diagnostics and the biomedical field. This paper has experimented with various ensemble algorithms and time-domain features to classify eight types of hand gestures. To train and test the machine learning models, we have extracted eight types of time-domain features from the raw EMG signals, such as integrated EMG (IEMG), variance, mean absolute value (MAV), modified mean absolute value type 1, waveform length, root mean square, average amplitude change, and difference absolute standard deviation value. The ensemble machine learning models are based on stacking, bagging, and gradient boosting. We have used four different-sized training sets to evaluate the performance of these classifiers. From the performance evaluation, we have identified the XG-Boost (gblinear) classifier with the IEMG feature as the best classifier-feature pair. The proposed classifier-feature pair has given better performance with a classification accuracy of 98.33% and a processing time of 5.67 μs for one vector than the existing extended associative memory-MAV classifier-feature pair.
Bioremoval of PVP coated silver nanoparticles using Aspergillus niger: the role of exopolysaccharides
Authors: Gomaa Ola M. , Alrshim Amar , Chanda Anindya 
Published: July 2021

Abstract
The present work aims to study the removal of Polyvinylpyrrolidone coated silver nanoparticles (PVP-Ag-NPs) using Aspergillus niger and depict the role of exopolysaccharides in the removal process. Our results show that the majority of PVP-Ag-NPs were attached to fungal pellets. About 74% and 88% PVP-Ag-NPs were removed when incubated with A. niger pellets and exopolysaccharide-induced A. niger pellets, respectively. Ionized Ag decreased by 553 and 1290 fold under the same conditions as compared to stock PVP-Ag-NP. PVP-Ag-PVP resulted in an increase in reactive oxygen species (ROS) in 24h. The UV-Visible spectrum shows the disappearance of Ag characteristic peak and the broadness of the spectrum suggested an increase in size. Dynamic Light Scattering results showed an increase in PVP-Ag-NPs size from 28.4 nm to 115.9 nm for A. niger pellets and 160.3 nm after removal by stress-induced A. niger pellets and further increased to 650.1 nm for in vitro EPS removal. Our findings show that EPS can be used for nanoparticle removal, by increasing the net size of nanoparticles in aqueous media, this will, in turn, facilitate its filtration through conventional filtration techniques commonly used at wastewater treatment plants.
Aloe Vera Protects Fluoride Induced Teratogenic Effects During Pre- and Postnatal Development in Mice
Authors: Mathur Priyanka , Choudhary Shilpa , Bhatnagar Pradeep 
Published: July 2021

Abstract
Pregnancy and feto-gestational toxicities on exposure to fluoride (F) and its possible amelioration on co-administration with Aloe-vera were studied in pregnant Swiss albino mice. Once the confirmed pregnancy was tested, animals were equally divided into four groups and were given following treatment. Group I was given no treatment and served as Control, Group II and III were administered sodium fluoride, 100 and 300 ppm respectively while group IV was co-administered with sodium fluoride, 300 ppm and Aloe-vera (300mg/kg) daily for 14 days prior to gestation and continued till the 18th day of gestation. Animals were sacrificed `on the 19th day of gestation for prenatal observations. Maternal body weight, the gravid uterine weight, number of corpora lutea in both the ovaries, number of implantations and resorptions, number of live (mature and immature ) male and female fetuses as well as number of dead fetuses were examined in each dam. The treatment continued in another set of animals till the completion of weaning period to observe postnatal changes due to test substances on the mother and pups. Sodium fluoride treated animals showed morphometric and skeletal changes which were more pronounced in the high dose group showing significantly decreased body weight gain in pregnant mothers; and dead/immature fetuses. Morphometric changes included open eyelids, limb defects, wrinkles on whole body, anophthalmias, pulmonary edema, enlarged esophagus and decreased body weight of fetuses and pups. Alizarin prepared skeletal structures of fetuses of such female mice showed delayed ossification or bending in number of bones of skull, thoracic and limb regions. However, concomitant exposure to Sodium Fluoride and Aloe-vera treated animals, there was a marked improvement in all the prenatal and postnatal variables. The study suggests that Sodium fluoride at the high concentrations may be teratogenic while co-administration of Aloe-vera during fluoride exposure might be beneficial in reducing these toxic effects. We thus recommend use of aloe vera as preventive agent or as a complimentary agent during fluoride treatment.
The Mechanism Insight Into the Inhibitory Effect of Artemisinin Sustained-release Inhibitors With Different Particle Sizes on Microcystis aeruginosa
Authors: Jiang Zhiyun , Ni lixiao , Li Xianglan , Xu Chu , Chen Xuqing , Li Shiyin 
Published: July 2021

Abstract
Environment-friendly algaecides based on allelopathy have been widely used to control harmful algal blooms. In this research, micro nano scale artemisinin sustained-release algal inhibitor was prepared, the optimal preparation conditions were explored and the inhibitory mechanism of artemisinin algaecides was perfected. The results showed that when the particle size of artemisinin sustained-release microspheres (ASMs) was 2/10000 of artemisinin sustained-release granules (ASGs), the inhibitory effect was more remarkable. The optimal concentration of ASMs was 0.2 g L-1, and the inhibitory effect reached 99% on the 10th day; The algae density and chlorophyll-a both showed a downward trend, indicating that ASGs and ASMs could promote the degradation of chlorophyll-a; The inhibition rate of ASGs was faster than that of ASMs on the 4th day, and the inhibitory effect of ASMs was more significant after the 5th day. The activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT) increased rapidly at first and then decreased, which indicated that ASGs and ASMs caused oxidative damage to Microcystis aeruginosa (M. aeruginosa) and inhibited the activity of antioxidant enzymes. Furthermore, the content of the oxygen free radical (O2-) and malondialdehyde (MDA) continued to rise after the 5th day, the protein, nucleic acid and conductivity in the culture medium increased. These results showed that lipid peroxidation occurred in the algal cell membrane, and the permeability of the membrane increased. In summary, the ASMs had significant continuous inhibitory effect while the ASGs had better short-term effect. The main inhibitory mechanism of artemisinin algaecides is the irreversible damage of cell membrane.
Hospital-prepared low-dose atropine eye drops for myopia progression control using atropine sulfate injection diluted in normal saline and lubricants
Authors: Wongwirawat Nuthida , Kuchonthara Nirachorn , Boontanomwong Sorrawit , Pongpirul Krit 
Published: July 2021

Abstract
Background As commercial low-dose atropine eye-drops for myopia progression control are available in some countries, in-house preparation by diluting the 0.1% atropine eye-drop with sterile water or normal saline has been a common practice. Atropine injection is readily available and could be a more feasible alternative.Objective To assess the properties of the in-house low-dose atropine eye-drops prepared by diluting the atropine injection in two solvents and tested in two temperature conditions.Method The 0.01% atropine eye-drops (15ml) were prepared by diluting atropine sulfate injection with normal saline and lubricant eye-drops and stored at room temperature and in a refrigerator. All samples were daily dropped for 12 weeks to mimic real-life use, one of which was assessed every two weeks for the biological contamination and chemical properties. The active substance was compared with freshly prepared samples at the 12th week.Results The 0.01% atropine eye-drops contains no bacteria, fungi, or particulate matter. The levels of atropine sulfate on all samples were comparable to the freshly prepared samples at the 12th week, regardless of the solvents used or storage conditions.Conclusion The low-dose atropine eye-drops prepared from readily available atropine sulfate injection at healthcare facilities could be alternative to commercial products
Facemask Detection With an Alarm System and Email Notification Using Deep Learning to Prevent Spread of COVID-19
Authors: Sankla Vinita , Patidar Savitanandan , kushwaha Vishal , Bagwari Ashish , Tiwari Rahul , Qamar Shamimul , Verma Gaurav 
Published: July 2021

Abstract
COVID-19 is one of the most dangerous viruses which caused a pandemic in human life, not only in terms of direct casualties but also regarding socio-economic impact. The outbreak quickly spread around the world. The 1st anniversary of the global Corona virus pandemic gets passed away in 2021, but still, no way to tell how long the pandemic will continue. After analyzing a report by WHO of covid-19, to minimize the rate of covid-19 transmission, our national government advised citizens to wear face masks. A model using deep learning and MobileNetV2 for face mask detection is presented. This method was trained and checked on the real-time dataset. There are 3,833 images in the Medical Masks Dataset, including 1918 images of people wearing no mask and 1915 images of people wearing masks. We adopted OpenCV to detect faces in real-time from a live stream captured with our webcam. With the aid of computer vision and deep learning, we hope to classify whether or not the person in the video stream is wearing a face mask. If the camera captures a face without a mask an Email notification will be sent out to the administrator and the system alarm will ring.