bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychotherapy in Old Age: Older Adults’ Sexual Distress Concerning Their Sexual Well-Being
Authors: von Humboldt Sofia , Ribeiro-Gonçalves José , Low Gail , Leal Isabel 
Published: November 2021

Abstract
Age and sexual difficulties show a relevant influence in older adults’ sexual well-being (SWB). The objective of this study was to assess sexual issues that affect SWB, revealed by older adults in person-centered therapy, using qualitative research. Interviews with 38 older participants, aged 65 to 82 years, living in the community were submitted to content analysis. Eight main themes emerged from the results of the content analysis: Partner unavailability, family issues, physical changes, worries about hygiene, sexual dysfunctions, fear of physical abuse, and sexual transmitted diseases. This study was relevant towards identifying the sexual issues older adults feel regarding their SWB, as shared in therapy. Older adults referred their greatest issues to be partner unavailability, sexual dysfunctions and physical changes due to aging.
Correlation of Population Factors, Compliance With Masking and Social Distance, Vaccination and Covid-19 Infection in Central Appalachia: A Cross-Sectional Study
Authors: Moore J. Suzanne , Virk Hibah , Summers Jeffrey A 
Published: November 2021

Abstract
BackgroundCompliance with guidelines, including the use of masks and social distancing and vaccinations has been poor. Our study examined what factors may identify those who will be more or less compliant especially with regards to those with identified higher risk. MethodsA telephone survey of 200 adult patients from two practices, one General Internal Medicine and the other Rheumatology, was performed in May and June of 2021. Questions included age, sex, perception of immunocompetence, smoking history, mask and social distancing compliance, Covid-19 symptoms and/or test proven infection, and immunization status for Covid-19. Those agreeing to participate also had a chart review for body mass index (BMI), physician assessed immunocompetence, and diabetes.ResultsNo clinical factors approached statistical significance for prediction of compliance or non-compliance. However, compliance with mask and social distancing highly correlated with vaccination and avoidance of infection.ConclusionAttempts to improve compliance cannot be focused on any of the particular groups examined in this study.
Modeling and Analysis of Unbalanced Magnetic Pull in Synchronous Motorized Spindle Considering Magneto-thermal Coupling
Authors: feng wei , Zhang Kun , Liu Zongyao , Liu Baoguo , Zhang Huijuan , Mei Junwei , Wu Luji 
Published: November 2021

Abstract
The unbalanced magnetic pull (UMP) is one of the main vibration sources of the motorized spindle. A calculation model of UMP in a synchronous motorized spindle considering the magneto-thermal coupling is proposed in this paper. The finite element analysis models of the electromagnetic field and the temperature field of a motorized spindle are first established. Then a two-way coupling analysis method considering the effect of temperature variations on electromagnetic material properties of the motor is proposed. An experiment is conducted to verify the efficiency of this method. The thermal deformations of the spindle are calculated and used to analyze the air-gap variations between rotor and stator of the built-in motor. The 3D finite element electromagnetic model is adopted to calculate the UMP in the motorized spindle. The analysis results show that the eccentricity caused by thermal deformation can generate large UMP in the motorized spindle.
High Burden of Hypertension Among Adult Population in Rural Districts of Northwest Ethiopia: a Call for Community Based Intervention
Authors: Teshome Destaw Fetene , Balcha Shitaye Alemu , Ayele Tadesse Awoke , Atnafu Asmamaw , Sisay Mekonnen , Asfaw Marye Getnet , Mitike Getnet , Gelaye Kassahun Alemu 
Published: November 2021

Abstract
Background: Estimating prevalence and identifying risk factors of hypertension are paramount important to develop strategies to prevent hypertensive disease. Although, hypertension is a major public health problem in Ethiopia, there is scarcity of evidence in rural areas of the country. Hence, this study is aimed to assess the prevalence and risk factors of hypertension among adult population in rural districts of northwest Ethiopia.Methods: Community based cross sectional study was conducted from June to October, 2020. Multistage cluster sampling technique was used to select 1177 study participants. A face to face interview was conducted using an adapted version of the WHO STEPwise approach questionnaire. The blood pressure was measured three times using aneroid sphygmomanometer and the mean of the last two readings were used for the analysis. Data were entered using Epidata and analyzed using STAT-14. Multivariable logistic regression was used to identify risk factors associated with hypertension.Results: Of the total participants, 218(18.5%) were found to be hypertensive. The prevalence of hypertension consistently increased with age. Hypertension was positively and significantly associated with female sex ((adjusted odd ratio (AOR)=2.30, 95% CI: 1.53, 3.45)), age group 45-54 years (AOR=4.63, 95% CI: 1.01, 21.37), 55-64 years (AOR=14.40, 95% CI: 3.07, 67.63), ³65 years (AOR=19.37, 95% CI: 4.03, 93.09), having history of alcohol consumption (AOR=3.25, 95% CI: 1.17, 9.02), used much amount of salt (AOR=2.37, 95% CI: 1.53, 3.60), used too much amount of salt (AOR=3.78, 95% CI: 1.85, 7.72), sleeping for a short duration (AOR=2.05, 95%CI: 1.30, 3.24), and having Family history of hypertension (AOR=2.12, 95% CI; 1.32, 3.39). Conclusions: Hypertension was significantly high among the rural population we studied and is emerging as a public health problem in rural areas. Female sex, older age, ever used alcohol, used much and too much amount of salt, inadequate sleep, and family history of hypertension were factors positively and significantly associated with hypertension. We recommend local health authorities integrate promotion of hypertension health education, lifestyle modification intervention on salt and alcohol reduction, and hypertension detection particularly for female and elderly population at health post level to avert the problem.
Vascular Access Blood Flow Estimation Based On Standardized Extracorporeal Blood Flow in Hemodialysis Patients
Authors: Mora-Bravo Franklin Geovany , González Sonia Catalina Rivera , Torres Pamela Tatiana Morales , Ullauri Marco Rivera 
Published: November 2021

Abstract
Background: Measurement of vascular access flow (Qa) is a recommendation in the care of hemodialysis patients. We developed an observational study to answer the following question: Can access blood flow be estimated?Methods: This observational study was carried out in the hemodialysis unit of the José Carrasco Arteaga Hospital in Cuenca-Ecuador. The sample calculation was 41 cases. Patients older than 17 years with stage 5d chronic renal failure and vascular access with arteriovenous fistula were included. The variables were descriptive of the population: Qa and extracorporeal blood flow (Qb). Qa measurement was performed with the Transonic ® monitor. Qb was measured at dynamic arterial line pressures (DALPs) of -60 mmHg, -100 mmHg, -160 mmHg, and -200 mmHg. The correlation coefficient "r" was obtained between Qa and Qb. SPSS 22.0 was used to analyze the information and perform a linear regression equation to estimate access blood flow (eQa).Results: Fifty-seven patients aged 62.9 ± 12.7 years with 29.4 ± 33 months on hemodialysis were included; 23 women (40.3%) and 45.6% had diabetic nephropathy. Fistulas were seen in 40 cases in the left upper limb (70.2%) and 17 (29.8%) in the right upper limb. The prevalence of aneurysms was 10.5%. The 50th percentile of Qb was 415 mL/min with a DALP of -200 mmHg. The mean access flow was 1516 ± 878 ml/min. The correlation between Qb and Qa was statistically more significant between Qb and DALP of -200 mmHg. The association had a coefficient Rs = 0.643 (IC 0.453 to 0.771) P <0.0001. The estimated access flow eQa = (Qb at DALP of -200 mmHg (mL/min) * 16.63) - 5449.71.Conclusions: It was possible to estimate access blood flow with parameters for easy intradialysis measurements. The equation obtained, if applied to the same patient with the same DALP, could become a useful parameter for monitoring vascular access.Trial registration: ClinicalTrials.gov Identifier: NCT00522704. Registered 14 March 2008, https://clinicaltrials.gov/ct2/show/NCT00522704
ANALYSIS OF METASTASIS-FREE SURVIVAL IN PATIENTS WITH SMALL CHOROID MELANOMA DEPENDING ON THE TYPE OF PRIMARY TUMOR TREATMENT
Authors: Navumenko L. V. , Krasny S. A. , Zhylayeva K. P. , Evmenenko A. A. , Zherko I. Y. 
Published: October 2021

Background. There is no unified approach to the management of patients with small choroid melanoma (CM) (thickness up to 3 mm, base diameter up to 10 mm). The study of the development of metastases in these patients is of great significance for choosing an appropriate treatment method.Purpose: to assess the incidence of metastatic disease in patients with small CM, who were treated with transpupillary thermotherapy (TTT), photodynamic therapy (PDT), and brachytherapy (BT).Material and Methods. The retrospective study included 149 patients with CM, who were treated at the National Cancer Center of Belarus from 2005 to 2018. All patients had tumors less than 10 mm in diameter, less than 3 mm in thickness, and had no signs of systemic progression before starting therapy. All tumors corresponded to stage T1N0M0 (American Joint Committee on Cancer (AJCC)). 44 patients were treated with PDT, 47 with TTT, and 58 with BT.Results. The median follow-up time was 154 months (12 years) in patients treated with brachytherapy, 128 months (10 years) in patients treated with TTT and 72 months (6 years) in patients treated with PDT. During the follow-up period, metastases were observed in 1 (2.3 %) patient after PDT and in 5 (10.6 %) patients after TTT. In patients treated with BT, systemic progression was not recorded during the follow-up period. All cases of metastatic disease were associated with local recurrence or continued growth of CM.Discussion. The 5-year metastasis-free survival after TTT was worse than after PDT (82 ± 8.0 % and 94 ± 6.0 %, respectively, p<0.0001). However, in some cases, preference can be given to laser treatment methods, allowing the patients to avoid post-radiation retinopathies. The lack of local control of the tumor can be considered a surrogate marker for the development of metastatic disease. Conclusion. The highest metastasis-free rates were observed after brachytherapy. Positron emission tomography is recommended for early detection of systemic progression of the disease. Key words: choroid melanoma, uveal melanoma, transpupillary thermotherapy, photodynamic therapy, brachytherapy, metastatic-free survival, organ-preserving treatment.>˂0.0001). However, in some cases, preference can be given to laser treatment methods, allowing the patients to avoid post-radiation retinopathies. The lack of local control of the tumor can be considered a surrogate marker for the development of metastatic disease.Conclusion. The highest metastasis-free rates were observed after brachytherapy. Positron emission tomography is recommended for early detection of systemic progression of the disease.
MODERN OPPORTUNITIES OF PET/CT IN THE DIAGNOSIS OF PROSTATE CANCER
Authors: Vyazmin V. V. , Zukov R. A. , Chanchikova N. G. , Levchenko E. A. , Chernov V. I. 
Published: October 2021

The purpose is to present a modern data on the possibilities of positron emission computed tomography combined with computed tomography (PET/CT) in the diagnosis, staging and monitoring of prostate cancer (PC).Material and Methods. A search and analysis of the largest domestic and English-language databases (Elibrary, PubMed, Elsevier, etc.) on this problem was carried out. 37 sources were found devoted to studying the results of clinical trials of the diagnostic capabilities of PET/CT with various radiopharmaceuticals.Results. The presented data on the possibilities of PET/CT with various radiopharmaceuticals in the diagnosis of primary prostate cancer, imaging of lymphogenous and distant metastases, as well as in assessing the effectiveness of treatment.Conclusion. This review of the literature showed that the use of PET/CT in prostate cancer largely depends on the chosen radiopharmaceutical. Moreover, it is PET/CT with PSMA-based radiopharmaceuticals that is the most promising method for examining patients with prostate cancer and can be recommended as an additional study in cases where other methods of radiation diagnostics do not give an unambiguous answer. The development of new and improving the already used radiopharmaceuticals, which will increase the sensitivity, specificity and accuracy of the diagnosis, staging, monitoring and prognosis of treatment of prostate cancer, remains relevant.
DEVELOPMENT AND CHARACTERISATION OF 3D SOLID TUMOUR CELL MODELS FOR INDIVIDUALIZED CANCER TREATMENT
Authors: Danilova A. B. , Nekhaeva T. L. , Efremova N. A. , Maydin M. A. , Fedoros E. I. , Baldueva I. A. 
Published: October 2021

Background. To solve the problems of personalized medicine in oncology, preclinical studies based on the use of three-dimensional cellular models of tumors in vitro, including spheroids / tumoroids, are of great importance. They are an interesting tool for genetic, epigenetic, biomedical and pharmacological studies aiming to determine the most effective individual therapeutic approaches, since they allow modeling the dynamic evolution of a tumor disease from early stages to metastatic spread through interaction with the microenvironment.The purpose of the study was to compare characteristic features of formation and spatial organization of spheroids, obtained from solid malignant tumors cells with various histogenesis: melanomas, soft tissue sarcomas and osteosarcomas, epithelial tumors.Material and Methods. Solid tumor cell lines of patients who were treated from 2015 to 2021 were the basis for the creation of 3D-cell models. Fragments of tumor tissue were obtained intraoperatively: 15 samples of melanoma, 20 samples of soft tissue sarcomas and osteosarcomas, and 9 samples of epithelial tumors. All tumor cells were cultured for at least 10 passages. Methods of phase contrast, confocal microscopy, and histological techniques were used to study spheroids. Using ELISA methods and multiplex analysis, the supernatants of monolayer cell cultures and spheroids were studied for the presence of a wide range of biologically active substances that provide the processes of immunosuppression, invasion and metastasis.Results. The use of low adhesion surfaces was proven to be preferable to obtain spheroids of a given seed concentration and size of interest. The average cultivation time of spheroids was 4.7 days, and the optimal seeding concentration was 10,000 cells per well, while the spheroid diameter varied from 300 to 1000 μm depending on the type of malignant cells: the largest spheroids formed melanoma cultures. In general, the efficiency of spheroid formation was 88.6 % (39 out of 44). The introduction of fibroblasts into the 3D construct led to increasing in the invasive potential of tumor cells, which was associated with the production of IL8 (rho=0.636, p=0.035), HGF (rho=0.850, p=0.004), SCF (rho=0.857, p=0.014), FST (rho=0.685, p=0.029), Prolactin (rho=0.810, p=0.015), PECAM1 (rho=0.788, p=0.004).Conclusion. The technology of low-adhesive surfaces makes it possible to successfully create three-dimensional models of a tumor node from malignant tumors cells of various histogenesis. The colonization of a three-dimensional structure with fibroblasts enhances the biologically aggressive properties of tumor cells and demonstrates complex reciprocal interactions between the cellular elements of the tumor stroma and malignant cells, which brings the model closer to a real clinical situation.
COMPARATIVE ANALYSIS OF THE ACTIVITY OF GLYCOPEPTIDES AND LINEZOLID AGAINST NOSOCOMIAL STRAINS OF GRAM-POSITIVE MICROORGANISMS ISOLATED FROM CANCER PATIENT
Authors: Dmitrieva N. V. , Petukhova I. N. , Grigoryevskaya Z. V. , Bagirova N. S. , Tereshchenko I. V. , Klyuchnikova I. A. , Dyakova S. A. 
Published: October 2021

The purpose of the study: to compare the activity of vancomycin, teicoplanin and linezolid and to determine their place in the current treatment of nosocomial infections caused by gram-positive microflora.Material and Methods. 640 gram-positive microorganisms (S. aureus, E. faecium, E. faecalis) isolated in 2018 from various pathological materials from cancer patients treated at N.N. Blokhin National Medical Research Center of Oncology were studied. Literature data from 1982 to 2019, concerning efficacy of glycopeptides (vancomycin, teicoplanin) and linezolid against these pathogens were analyzed.Results. Data analysis showed that percentage of methicillin-resistant Staphylococcus aureus (MRSA) was 89 % and percentage of vancomycinresistant enterococci (VRE) was 5.1 % among Enterococcus faecalis and 16.4 % among Enterococcus faecium. The susceptibility of the studied gram-positive microorganisms to teicoplanin, vancomycin and linezolid ranged from 83.3 to 98.8 % (p>0.5). In general, teicoplanin, vancomycin, and linezolid had equally high microbiological activity against nosocomial strains of S. aureus and Enterococcus spp. Also, according to the literature data, a comparative assessment of the clinical effectiveness and cost-effectiveness of glycopeptides and linezolid was assessed.Conclusion. Vancomycin and teicoplanin are still the main drugs for the treatment of various infections caused by resistant gram-positive microflora. However, teicoplanin, with an efficacy equal to that of vancomycin, has a number of significant advantages over the latter: better tolerability, lower frequency of adverse reactions, and pharmacokinetic features that make it possible to use it once a day both intravenously and intramuscularly. Both drugs, along with linezolid, can be used to treat infections caused by gram-positive microorganisms in cancer patients.
Development of the social technology for constructing service workers’ ethics of behavior
Authors: Vilyamovich Anastasia , Rubtcova Mariia , Pavenkov Vladimir 
Published: October 2021

The findings of our previous research of the social construction of the ethics of the employees of the service industry in St. Petersburg in 2014 (N135) and in 2016 (N483) have been added to the modern research analysis of ethics constructing processes in an organization. The article presents a managerial aspect of the problem, specifically the development of a social technology for constructing service workers’ ethics of behavior. The results of the technology introduction into the activities of an organization in Russia are also submitted for consideration.
Mineral oil hydrocarbons: a new challenge for the oils and fats processing industry
Authors:   Desmet Ballestra Group, Gibon Véronique , De Greyt Wim 
Published: November 2021

Mineral oils are widespread food contaminants, and edible oils, like many other foodstuffs, are often contaminated. The lack of robust analytical methods and proper toxicological evaluation make it difficult to set a tolerance level. •	The best way to avoid mineral oil contamination is to prevent it by complying with good manufacturing practices, and the best solution to reducing mineral oil contamination in edible oils is through refining, especially during deodorization. This paper gives an overview of contamination sources, levels in some edible oils, regulatory aspects, analytical methods, and strategies for mitigation during refining.
La eficiencia en el sistema penal español: con especial referencia al modelo de conformidades
Authors: González Guarda Claudio Javier 
Published: October 2021

El presente trabajo, describe el modo en que algunas lógicas eficientistas se han posicionado en el sistema penal español. Con este objetivo, se ha realizado una revisión sistemática de la literatura político- criminal sobre la materia. Asimismo se han examinado las Circulares de la Fiscalía General del Estado, diversos informes sobre la Nueva Oficina Judicial (NOJ), estadísticas judiciales y los anteproyectos de códigos procesales penales (2011, 2013 y 2020), entre otras informaciones atinentes. De este modo determinamos tres ámbitos para observar este fenómeno: 1) en la literatura político-criminal respectiva; 2) en el intento de implementar un “gerencialismo orgánico” manifestado en la denominada Nueva Oficina Judicial; y 3) en el sistema de justicia negociada en España, especialmente en las conformidades. Concluimos que: a) A pesar de los escasos estudios sobre el gerencial/eficientismo en España, su penetración es indudable. Ciertamente de manera diferente a otros contextos (angloamericano y latinoamericano); b) La consolidación de un modelo eficientista de rasgos aceleracionistas de la justicia criminal se configura no solo debido a factores jurídicos, sino también a elementos socio-económicos, tecnológicos, y criminológicos; c) Su principal manifestación se observa en los procedimientos rápidos y en el modelo de conformidades (modo de terminar el litigio en el 70 % de las causas ordinarias y en el 90 % de los juicios rápidos); d) Los intentos de transformar toda la dimensión organizacional de la justicia penal no se han concretado.
Mapping out the path ahead for corporate criminal procedure law in People´s Republic of China
Authors: Santos Hugo Luz dos 
Published: October 2021

The tale of procedural fairness is, by now, familiar and well worn. People ́s Republic of China criminal system of justice, which is currently gearing towards the pathway of procedural fairness, has (for the better or for the worse) attracted a wide global gaze. Irrespective of the underlying fairness (or the lack thereof) of the grievances brought forth by a worldwide phalanx of critics, China is steadily toiling towards the path of procedural justice, which is rooted firmly in the Rule of Law. Whilst procedural justice and procedural fairness map seamlessly on to the context of corporate criminal procedure law, there is bevy of critical questions that are in dire need of being consistently addressed nonetheless. One which is whether and to what extent politically- charged tools, which seemingly belie the western-borne concept of separation of powers (as the Supreme People ́s Procuratorate Guiding Cases and, to some degree, Supreme People ́s Court Judicial Interpretations) are amenable to forge the path ahead to meeting the fundamental tenets of due process in corporate criminal procedure law in Mainland China. Against this background, this paper aims to answer two sweeping research questions. Firstly, the degree to which corporate governance (and corporate compliance) subdues (and foremost trumps) corporate criminal liability. Secondly, whether and to what extent SPP Guiding Cases have catalyzed a seismic shift in People ́s Republic of China criminal procedural law. Conversely,one central contention of this paper is that a set of fairness-fraught corollaries can be withdrawn from SPP Guiding Cases with a view to map the path forward to fulfilling the baseline standards of both procedural fairness and procedural justice in People ́s Republic of China corporate criminal procedure law.