bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting Metabolic Cross Talk Between Cancer Cells and Cancer-Associated Fibroblasts
Authors: Jung Jin G. , Le Anne 
Published: May 2021

AbstractAlthough cancer has classically been regarded as a genetic disease of uncontrolled cell growth, the importance of the tumor microenvironment (TME) [1, 2] is continuously emphasized by the accumulating evidence that cancer growth is not simply dependent on the cancer cells themselves [3, 4] but also dependent on angiogenesis [5–8], inflammation [9, 10], and the supporting roles of cancer-associated fibroblasts (CAFs) [11–13]. After the discovery that CAFs are able to remodel the tumor matrix within the TME and provide the nutrients and chemicals to promote cancer cell growth [14], many studies have aimed to uncover the cross talk between cancer cells and CAFs. Moreover, a new paradigm in cancer metabolism shows how cancer cells act like “metabolic parasites” to take up the high-energy metabolites, such as lactate, ketone bodies, free fatty acids, and glutamine from supporting cells, including CAFs and cancer-associated adipocytes (CAAs) [15, 16]. This chapter provides an overview of the metabolic coupling between CAFs and cancer cells to further define the therapeutic options to disrupt the CAF-cancer cell interactions.
Diabetes and Cancer: The Epidemiological and Metabolic Associations
Authors: Zhang Cissy , Le Anne 
Published: May 2021

AbstractDiabetes mellitus, commonly known as diabetes, and cancer are two of the most common diseases plaguing the world today. According to the Centers for Disease Control and Prevention (CDC), there are currently more than 20 million people with diabetes in the United States [1]. According to the International Agency for Research on Cancer (IARC), there were around 18 million people diagnosed with cancer, with approximately ten million deaths globally in 2018 [2]. Given the prevalence and deadliness of diabetes and cancer, these two diseases have long been the focus of many researchers with the goal of improving treatment outcomes. While diabetes and cancer may seem to be two very different diseases at first glance, they share several similarities, especially regarding their metabolic characteristics. This chapter discusses the similarities and relationships between the metabolism of diabetes, especially type 2 diabetes (T2D), and cancer, including their abnormal glucose and amino acid metabolism, the contribution of hyperglycemia to oncogenic mutation, and the contribution of hyperinsulinemia to cancer progression. Investigating the metabolic interplay between diabetes and cancer in an effort to exploit this connection for cancer treatment has the potential to significantly improve clinical efficacy.
The Heterogeneity of Lipid Metabolism in Cancer
Authors: Park Joshua K. , Coffey Nathan J. , Limoges Aaron , Le Anne 
Published: May 2021

AbstractThe study of cancer cell metabolism has traditionally focused on glycolysis and glutaminolysis. However, lipidomic technologies have matured considerably over the last decade and broadened our understanding of how lipid metabolism is relevant to cancer biology [1–3]. Studies now suggest that the reprogramming of cellular lipid metabolism contributes directly to malignant transformation and progression [4, 5]. For example, de novo lipid synthesis can supply proliferating tumor cells with phospholipid components that comprise the plasma and organelle membranes of new daughter cells [6, 7]. Moreover, the upregulation of mitochondrial β-oxidation can support tumor cell energetics and redox homeostasis [8], while lipid-derived messengers can regulate major signaling pathways or coordinate immunosuppressive mechanisms [9–11]. Lipid metabolism has, therefore, become implicated in a variety of oncogenic processes, including metastatic colonization, drug resistance, and cell differentiation [10, 12–16]. However, whether we can safely and effectively modulate the underlying mechanisms of lipid metabolism for cancer therapy is still an open question.
Novel leptoquark pair production at LHC
Authors: Doršner Ilja , Fajfer Svjetlana , Lejlić Ajla 
Published: May 2021

Abstract
We introduce a novel mechanism for the leptoquark pair production at LHC that is of a t-channel topology and is quark-quark initiated. This mechanism operates under fairly general conditions. One of them is that the two leptoquarks in question couple to the same lepton and the other one is that the fermion numbers of these two leptoquarks differ by two. The strength of the proposed mechanism provides an alternative way to the conventional processes to efficiently constrain the parameter space of the two leptoquark scenarios at LHC whenever the aforementioned conditions are met. We accordingly present one case study to outline the physics potential of this novel production mechanism.
Some properties of the QQq-quark potential in string models
Authors: Andreev Oleg 
Published: May 2021

Abstract
We propose a string theory construction which allows us to study properties of the potential of two heavy quarks coupled to a light quark. In such a case, the potential is a function of separation between the heavy quarks. The results show the universality of the string tension and factorization at small separations expected from heavy quark-diquark symmetry. In addition, we make an estimate of the string breaking distance. With the parameter values we use, this distance is found to be almost the same as that for the heavy quark-antiquark potential. We also discuss the heavy quark-quark potential and its relation to Lipkin rule.
Reduzierung des Zuckerkonsums für eine bessere Mundgesundheit – Welche Strategien sind Erfolg versprechend?
Authors: Heilmann Anja , Ziller Sebastian 
Published: May 2021

ZusammenfassungStrategien zur Gesundheitsförderung können einen wesentlichen Beitrag leisten, um nichtübertragbare chronische Krankheiten zu verhindern. Die wesentlichen nichtübertragbaren Erkrankungen in der Zahnmedizin sind Zahnkaries und Parodontalerkrankungen. Zucker spielt sowohl bei der Entstehung von Zahnkaries als auch von Übergewicht und dessen Folgen für die Allgemeingesundheit eine ursächliche Rolle und ist daher als wichtige kommerzielle Gesundheitsdeterminante mehr und mehr ins Blickfeld von Wissenschaft und Gesundheitspolitik gerückt. Existierende Strategien zur Reduktion des Zuckerkonsums zielen jedoch häufig auf Maßnahmen zur individuellen Verhaltensänderung ab und lassen dabei die Rolle von gesellschaftlichen und kommerziellen Einflüssen außer Acht.In diesem Artikel beschreiben wir die aktuellen Empfehlungen der Weltgesundheitsorganisation (WHO) zum Zuckerkonsum, Daten zum Zuckerverzehr in Deutschland sowie die sozialen und kommerziellen Faktoren, welche den Zuckerkonsum beeinflussen. Grundlegende Prinzipien der Gesundheitsförderung werden dargelegt und sich daraus ergebende Strategien zur Zuckerreduzierung diskutiert. Dabei werden konkrete Beispiele für Upstream- und Downstream-Ansätze benannt und Möglichkeiten der Einflussnahme durch die zahnmedizinische Community in Politik und Praxis aufgezeigt.
Kinematic analysis and process stability of ultrasonic-assisted drilling
Authors: Georgi Oliver , Rüger Carlo , Rentzsch Hendrik , Putz Matthias 
Published: May 2021

AbstractRegarding drilling, ultrasonic-assistance enables various potentials such as less tool wear, enhanced chip breaking and burr reduction. Although there are many technological studies verifying these advantages, no theory for process behaviour, design and parameter evaluation is available. Thus, this paper presents a kinematic analysis of the interaction between tool and workpiece to contribute to overall process understanding. Specific process scenarios are classified and characteristic parameters for the evaluation and design of ultrasonic-assisted drilling are determined. In addition, experimental investigations based on the developed process model are carried out analysing chip shape, bore surface and process stability acquired by acoustic measurements. The kinematic analysis shows the classification of ultrasonic-assisted drilling according to continuous and intermitted cutting conditions. In addition, the superposition of ultrasonic vibrations causes a modulation of uncut chip thickness related to the ratio of ultrasonic frequency and spindle speed. In general, experimental results show that ultrasonic-assisted drilling is leading to shorter chips. While using parameters for intermitted cutting conditions needle chips occur. At the same time, intermitted cutting conditions induce process instabilities identified using the acoustic measurement approach.
Ligamentous healing potential of the acromioclavicular ligament following acute anatomical reconstruction
Authors: Tuecking L. R. , Erdle B. , Bernstein A. , Ogon P. , Jaeger M. , Südkamp N. P. , Izadpanah K. , Maier D. 
Published: May 2021

Abstract
Background
Horizontal instability following acute acromioclavicular joint (ACJ) reconstruction still occurs with a high prevalence. Although the human acromioclavicular ligament complex (ACLC) represents the major horizontal ACJ stabilizer, experimental studies on healing characteristics are lacking. Therefore, the purpose of this histological study was to investigate the healing potential of the ACLC following acute anatomical reconstruction

Methods
In this prospective clinical-experimental study, 28 ACLC biopsies were performed in patients with complete ACJ dislocations (Rockwood type 4 or 5) during acute hook plate stabilization (IG: implantation group; n = 14) and hook plate removal (EG: explantation group; n = 14). Histological analyses included Giemsa staining, polarized light microscopy and immunostaining against CD68, αSMA and collagen type I and type III. Histomorphological evaluation entailed cell counts, collagen expression score, ligament tissue maturity index (LTMI) and descriptive analysis of specific ligamentous structures. Statistics consisted of nonparametric Mann–Whitney U tests and a level of significance of P < .05.

Results
Total cell counts (cells/mm2 1491 ± 296 vs. 635 ± 430; P < 0.001) and collagen III expression (3.22 ± 0.22 vs. 1.78 ± 0.41; P < 0.001) were higher in EG compared to IG. Inversely αSMA + (11 ± 9 vs. 179 ± 186; P < 0.001) and CD68 + cell counts (56 ± 20 vs. 100 ± 57; P 0.009) were significantly lower in the EG. The EG revealed a comparable reorientation of ligamentous structures. Consistently, ACLC samples of the EG (21.6 ± 2.4) displayed a high total but differently composed LTMI score (IG: 24.5 ± 1.2; P < 0.001).

Conclusions
This experimental study proved the ligamentous healing potential of the human ACLC following acute anatomical reconstruction. Histomorphologically, the ACLC reliably showed a ligamentous state of healing at a mean of about 12 weeks after surgery. However, processes of ligamentous remodeling were still evident. These experimental findings support recent clinical data showing superior horizontal ACJ stability with additional AC stabilization in the context of acute ACJ reconstruction. Though, prospective clinical and biomechanical studies are warranted to evaluate influencing factors on ACLC healing and potential impacts of acute ACLC repair on clinical outcome.

Study type
Controlled Laboratory Study
Mavoglurant (AFQ056) for the treatment of levodopa-induced dyskinesia in patients with Parkinson’s disease: a meta-analysis
Authors: Negida Ahmed , Ghaith Hazem S. , Fala Salma Yousry , Ahmed Hussien , Bahbah Eshak I , Ebada Mahmoud Ahmed , Aziz Mohamed Abd Elalem 
Published: May 2021

Abstract
Background
Mavoglurant (AFQ056), a selective metabotropic glutamate receptor 5 (mGluR5) inhibitor, was tested for t levodopa-induced dyskinesia (LID) in patients with Parkinson’s Disease (PD). However, clinical trials showed inconsistent results regarding the efficacy of mavoglurant in treating LID in patients with Parkinson's disease (PD).

Methods
A computer literature search of PubMed, Scopus, Web of science, and Cochrane CENTRAL was conducted until March 2021. We selected relevant randomized controlled trials comparing mavoglurant to placebo. Study data were extracted and pooled as mean difference (MD) in the meta-analysis model.

Results
Six RCTs were included in this meta-analysis with a total of 485 patients. Mavoglurant was not significantly superior to placebo in terms of the “off-time” (MD −0.27 h, 95% CI −0.65 to 0.11), “on time” (MD 0.29 h, 95% CI −0.09 to 0.66), Lang-Fahn activities of daily living dyskinesia scale (MD −0.95, 95% CI −1.98 to 0.07), UPDRS-III (MD −0.51, 95% CI −1.66 to 0.65), or UPDRS-IV (MD −0.41, 95% CI −0.85 to 0.03). However, the pooled modified abnormal involuntary movement scale favored the mavoglurant group than the placebo group (MD −2.53, 95% CI −4.23 to −0.82).

Conclusions
This meta-analysis provides level one evidence that mavoglurant is not effective in treating the LID in patients with PD.
Palaeozoic stromatoporoid diagenesis: a synthesis
Authors: Kershaw Stephen , Munnecke Axel , Jarochowska Emilia , Young Graham 
Published: May 2021

AbstractPalaeozoic stromatoporoids, throughout their 100-million + year history (Middle Ordovician to Late Devonian and rare Carboniferous), are better preserved than originally aragonite molluscs, but less well-preserved than low magnesium-calcite brachiopods, bryozoans, trilobites and corals. However, the original mineralogy of stromatoporoids remains unresolved, and details of their diagenesis are patchy. This study of approximately 2000 stromatoporoids and the literature recognises three diagenetic stages, applicable throughout their geological history. Timing of processes may vary in and between stages; some components are not always present. Stage 1, on or just below sediment surface, comprises the following: micrite filling of upper gallery space after death, then filling of any remaining space by non-ferroan then ferroan calcite in decreasing oxygen of pore-waters; partial lithification of associated sediment from which stromatoporoids may be exhumed and redeposited, evidence of general early lithification of middle Palaeozoic shallow-marine carbonates; microdolomite formation, with the Mg interpreted to have been derived from original high-Mg calcite (HMC) mineralogy (likely overlaps Stage 2). Stage 2, short distance below sediment surface, comprising the following: fabric-retentive recrystallisation (FRR) of stromatoporoid skeletons forming fabric-retentive irregular calcite (FRIC), mostly orientated normal to growth layers, best seen in cross-polarised light. FRIC stops at stromatoporoid margins in contact with sediment and bioclasts. FRIC geometry varies, indicating some taxonomic control. Evidence that FRIC formed early in diagenetic history includes syntaxial continuation of FRIC into some sub-stromatoporoid cavities (Type 1 cement), although others were pre-occupied by early cement fills (Type 2 cement) formed before FRR, preventing syntaxial continuation of FRIC into cavities. Likely contemporaneous with FRIC formation, stromatoporoids in argillaceous micrites drew carbonate from adjacent sediment during reorganisation of argillaceous micrite into limestone–marl rhythms that are also early diagenetic. Stage 3, largely shallow burial, comprises the following: dissolution and silicification, but these may have occurred earlier in stromatoporoid diagenetic histories (more data required); burial pressure dissolution forming stylolites.
Recovering a perturbation of a matrix polynomial from a perturbation of its first companion linearization
Authors: Dmytryshyn Andrii 
Published: May 2021

AbstractA number of theoretical and computational problems for matrix polynomials are solved by passing to linearizations. Therefore a perturbation theory, that relates perturbations in the linearization to equivalent perturbations in the corresponding matrix polynomial, is needed. In this paper we develop an algorithm that finds which perturbation of matrix coefficients of a matrix polynomial corresponds to a given perturbation of the entire linearization pencil. Moreover we find transformation matrices that, via strict equivalence, transform a perturbation of the linearization to the linearization of a perturbed polynomial. For simplicity, we present the results for the first companion linearization but they can be generalized to a broader class of linearizations.
Global Sensitivity Analysis of a Homogenized Constrained Mixture Model of Arterial Growth and Remodeling
Authors: Brandstaeter Sebastian , Fuchs Sebastian L. , Biehler Jonas , Aydin Roland C. , Wall Wolfgang A. , Cyron Christian J. 
Published: May 2021

AbstractGrowth and remodeling in arterial tissue have attracted considerable attention over the last decade. Mathematical models have been proposed, and computational studies with these have helped to understand the role of the different model parameters. So far it remains, however, poorly understood how much of the model output variability can be attributed to the individual input parameters and their interactions. To clarify this, we propose herein a global sensitivity analysis, based on Sobol indices, for a homogenized constrained mixture model of aortic growth and remodeling. In two representative examples, we found that 54–80% of the long term output variability resulted from only three model parameters. In our study, the two most influential parameters were the one characterizing the ability of the tissue to increase collagen production under increased stress and the one characterizing the collagen half-life time. The third most influential parameter was the one characterizing the strain-stiffening of collagen under large deformation. Our results suggest that in future computational studies it may - at least in scenarios similar to the ones studied herein - suffice to use population average values for the other parameters. Moreover, our results suggest that developing methods to measure the said three most influential parameters may be an important step towards reliable patient-specific predictions of the enlargement of abdominal aortic aneurysms in clinical practice.
English Language Standards in California, China and Mexico: History, Comparison, and Analysis
Authors: Na Li , Gregory Jolene Castillo , Téllez Kip 
Published: May 2021

AbstractLearning standards have become a prominent feature for schools and school systems worldwide. Our paper describes the development of recent English teaching standards in California, China, and Mexico, as well as analyzing them for their theoretical orientations. We begin with an overview and critique of the standards movement. Our analysis of the standards in California, China, and Mexico reveals a substantial shift from a grammatical accuracy focused approach towards a communicative approach to language instruction. While this turn may be welcomed by professional educators, there are practical policy questions to be answered. We end our paper by noting additional challenges to implementing the new standards. Our general assessment is that the authors of the standards firmly believe that the new guidelines will improve instruction.
Improvement of cooling performance of hybrid nanofluids in a heated pipe applying annular magnets
Authors: Li Guolong , Wang Jin , Zheng Hongxing , Xie Gongnan , Sundén Bengt 
Published: May 2021

AbstractIn this paper, convective heat transfer of Fe3O4–carbon nanotubes (CNTs) hybrid nanofluid was studied in a horizontal small circular tube under influence of annular magnets. The pipe has an inner diameter of 3 mm and a length of 1.2 m. Heat transfer characteristics of the Fe3O4–water nanofluid were examined for many parameters, such as nanoparticle volume fraction in the range of 0.4–1.2% and Reynolds number in the range of 476–996. In order to increase the thermal conductivity of the Fe3O4–water nanofluid, carbon nanotubes with 0.12–0.48% volume fraction were added into the nanofluid. It was observed that for the Fe3O4–CNTs–water nanofluid with 1.44% volume fraction and under a magnetic field, the maximal local Nusselt number at the Reynolds number 996 increased by 61.54% compared with without a magnetic field. Results also show that compared with the deionized water, the maximal enhancements of the average Nusselt number are 67.9 and 20.89% for the Fe3O4–CNTs–water nanofluid with and without magnetic field, respectively.
Backbone curves, Neimark-Sacker boundaries and appearance of quasi-periodicity in nonlinear oscillators: application to 1:2 internal resonance and frequency combs in MEMS
Authors: Gobat Giorgio , Guillot Louis , Frangi Attilio , Cochelin Bruno , Touzé Cyril 
Published: May 2021

AbstractQuasi-periodic solutions can arise in assemblies of nonlinear oscillators as a consequence of Neimark-Sacker bifurcations. In this work, the appearance of Neimark-Sacker bifurcations is investigated analytically and numerically in the specific case of a system of two coupled oscillators featuring a 1:2 internal resonance. More specifically, the locus of Neimark-Sacker points is analytically derived and its evolution with respect to the system parameters is highlighted. The backbone curves, solution of the conservative system, are first investigated, showing in particular the existence of two families of periodic orbits, denoted as parabolic modes. The behaviour of these modes, when the detuning between the eigenfrequencies of the system is varied, is underlined. The non-vanishing limit value, at the origin of one solution family, allows explaining the appearance of isolated solutions for the damped-forced system. The results are then applied to a Micro-Electro-Mechanical System-like shallow arch structure, to show how the analytical expression of the Neimark-Sacker boundary curve can be used for rapid prediction of the appearance of quasiperiodic regime, and thus frequency combs, in Micro-Electro-Mechanical System dynamics.
A novel image encryption algorithm based on least squares generative adversarial network random number generator
Authors: Man Zhenlong , Li Jinqing , Di Xiaoqiang , Liu Xu , Zhou Jian , Wang Jia , Zhang Xingxu 
Published: May 2021

AbstractIn cryptosystems, the generation of random keys is crucial. The random number generator is required to have a sufficiently fast generation speed to ensure the size of the keyspace. At the same time, the randomness of the key is an important indicator to ensure the security of the encryption system. The chaotic random number generator has been widely used in cryptosystems due to the uncertainty, non-repeatability, and unpredictability of chaotic systems. However, chaotic systems, especially high-dimensional chaotic systems, have slow calculation speed and long iteration time. This caused a conflict between the number of random keys and the speed of generation. In this paper, we introduce the Least Squares Generative Adversarial Networks(LSGAN)into random number generation. Using LSGAN’s powerful learning ability, a novel learning random number generator is constructed. Six chaotic systems with different structures and different dimensions are used as training sets to realize the rapid and efficient generation of random numbers. Experimental results prove that the encryption key generated by this scheme can pass all randomness tests of the National Institute of Standards and Technology (NIST). Hence, our result shows that LSGAN has the potential to improve the quality of the random number generators. Finally, the results are successfully applied to the image encryption scheme based on selective scrambling and overlay diffusion, and good results are achieved.