bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competitive Adsorption Mechanism of Mixed Gases in the Molecular Model of Hydrated Shale
Authors: Liu Jianyi , Wen Yimin , Yuan Hua , Liu Zhibin , Shui Zhengwei , Ba Yujiang , Gun Minjian , Pan Gongheng , Yang Yuzhong 
Published: February 2025

Summary
Conducting the competitive adsorption mechanism of methane (CH4)/carbon dioxide (CO2) and the impact mechanism of water (H2O) is crucial for providing guidance for the evaluation of geological reserves in shale gas reservoirs and CO2 injection production. Therefore, based on the established heterogeneous shale molecular model, the competitive adsorption mechanism was simulated using molecular dynamics (MD) and grand canonical Monte Carlo (GCMC) simulation. Results revealed that, as CO2 content increased, CH4 adsorption capacity gradually decreased and adsorption capacity was gradually suppressed. When CO2 content increased to a certain value, the adsorption capacity of CH4 tended to approach equilibrium, indicating that shale has a stronger adsorption capacity for CO2. With the increase in H2O content, the adsorption capacity, adsorption rate, and saturation adsorption capacity of both CH4 and CO2 on shale decreased while reduction amplitude also decreased, indicating that an increase in H2O content in shale formations had a certain inhibitory effect. However, under high-pressure and high H2O content conditions, the influence of H2O on gas adsorption capacity decreased. Furthermore, the average isosteric adsorption heat range of CH4 in shale was 12.07–12.74 kJ/mol, while that for CO2 was 14.49–15.33 kJ/mol, indicating that the adsorption type of both gases in shale is physical.
The Unpredictable Business Environment in Cameroon: Delving into the Challenges Entrepreneurs Face Importing Goods and Exploring Potential Solutions
Authors: Kouam Arthur William Fodouop , Catche Fadila , Timba Gaëlle Tatiana 
Published: February 2025

Abstract

This study investigates the challenges faced by entrepreneurs in Cameroon, with a specific focus on the impact of fluctuating customs costs on their operations. Employing a mixed-methods approach that integrates both quantitative and qualitative analyses, the research includes a survey of 210 entrepreneurs across major urban centers and thematic interviews that provide in-depth insights. The findings reveal a robust positive correlation (β = 0.675, p < 0.001) between rising customs costs and operational challenges such as shipping delays and increased financial strain. A significant portion of entrepreneurs reported adapting through strategies such as supplier diversification and the adoption of digital tools, which were statistically linked to improved resilience in managing customs-related obstacles. Additionally, our analysis using Ordinary Least Squares (OLS) regression confirmed the importance of financial access as a moderating factor in dealing with customs costs. The study contributes to the existing literature by providing empirical insights into the interplay of customs costs and entrepreneurial resilience while offering practical solutions for policymakers to enhance the business climate in Cameroon, including the need for more transparent regulations and improved industry networking.
Characterization of the area to be used as a sanitary landfill in southeastern Brazil applying electrical resistivity and induced polarization methods
Authors: Jardim Roberta Layra Faragó , Pejon Osni José , Elis Vagner Roberto 
Published: February 2025

Abstract

The increase in municipal solid waste (MSW) generation observed over the years has sparked important discussions regarding its disposal. When MSW is disposed of in sanitary landfills, proper design according to current standards and constant monitoring can prevent environmental impacts. Geophysical methods have been used for subsurface characterization and contaminants monitoring, particularly geoelectrical methods, proving to be efficient and cost-effective. These indirect methods allow for a more comprehensive two-dimensional evaluation of the subsurface, which is impractical through direct surveys. This study aimed to demonstrate the efficiency of electrical resistivity and induced polarization methods in the characterization of MSW disposal areas. The study focused on the current sanitary landfill of São Carlos, Brazil, which was still under geological-geotechnical investigation at the time of the geophysical surveys. Electrical resistivity lines were conducted with a dipole-dipole array to investigate the physical properties of resistivity and chargeability. During the excavation of the first trench of the sanitary landfill in 2013, rock was identified at a shallow depth in a region where SPT results did not indicate the presence of rock at depths less than 17 meters. However, geoelectrical results revealed rocks at shallower depths. These results confirmed the potential of geoelectrical methods in identifying the diabase bedrock. The bedrock was delimited using resistivity profiles for values higher than 350 ohm.m. The chargeability profiles were employed as an auxiliary method to validate the results, showing increasing values with depth and resistivity.
Evaluation of Pre and Post-Emergence Herbicides: It’s Effect on Weed Dynamics, Yield, and Yield Components of Barley (Hordeum vulgare L.) in Awi Zone, Northwestern Ethiopia
Authors: Yilma Abebe , Wendaferew Demekech , Debebe Nardos , Abebaw Yekoye , Tilahun Yibeltal 
Published: February 2025

Abstract

Field experiments were conducted to evaluate different herbicides’ efficacy and their effect on yield and yield component of barley. Results of the experiment revealed that the dry weight of weeds, yield and most yield components of barley were significantly affected by the type of herbicides applied. Thus, the maximum weed dry weight of 206.7 gm-2 was recorded from the weedy check followed by plots treated with crop star 93.1gm-2 in Guagusa Shikudad. However, the least was obtained from plot treated with two times hand weeding (26.23 gm-2) in Banja district next to dry weight of weeds from the weed-free check (0.00gm-2). Besides, the maximum grain yield of 3238.9kg ha-1 and 3220kg ha-1, respectively was recorded from weed-free checks and plot received musket power treatment at Banja. The application of Musket power expressed the maximum marginal rate of return (174.61) and net benefit, reflecting effective management of weeds in barley.
Flexural behavior of concrete beam and slab with novel demountable connectors
Authors: Li Wei , Chen Wei , Jiang Huaming , Kong Zhengyi 
Published: February 2025

Abstract

In this study, a new type of novel demountable connectors is proposed to enable complete dry connections between concrete beams and slabs, facilitating the full demountable design of these components. To analyze and evaluate the flexural performance of the concrete beams with the novel demountable connectors, a finite element model is developed, which is then validated by previous tests. The results indicate that bolt diameter, bolt strength, channel spacing, and concrete slab thickness have a significant impact on peak load, while concrete beam strength, concrete slab strength, and flange width have minimal influence. Similarly, flexural stiffness is strongly affected by bolt diameter, channel spacing, concrete slab strength, slab thickness, and flange width, whereas bolt strength and concrete beam strength play a lesser role. Notably, the finite element analysis confirms the absence of plastic deformation in most bolts and end plates, ensuring that the flexural components are designed for effective disassembly. A theoretical model for calculating the ultimate flexural moment of demountable concrete beams under different conditions is also proposed, and it agrees with the ultimate flexural moment from numerical analysis.
An in silico journey of right ventricular growth and remodelling after pulmonary valve regurgitation
Authors: Gao Hao , Guan Debao , Danton Mark 
Published: February 2025

Abstract

Digital twins of cardiac function are revolutionizing the management of heart diseases. Pulmonary valve regurgitation (PR), a common complication following repair of tetralogy of Fallot, can lead to detrimental effects on right ventricular (RV) function if it persists. Although pulmonary valve replacement can address PR, its long-term effects remain a topic of debate. Despite the importance of RV in overall cardiac function, high-fidelity in-silico models of the right ventricle remain under-explored. In this study, we present a novel mathematical framework to simulate RV growth and remodelling in response to acute PR, along with long-term structural and functional adaptations, and reversible recovery post-intervention. We employ a subject-specific bi-ventricular model integrated with a lumped systemic circulation model, where myocardial mechanics are decomposed into passive and active components, and myocardial growth and remodelling are modelled through a kinematic approach with updated references constrained by biological limits. This framework allows us to model RV response to acute and chronic PR, and subsequent recovery following clinical intervention. For the first time, we demonstrate that RV pump function can return to normal if myocytes retain sufficient functional and structural reserve before interventions. This work marks a significant step toward the realization of digital twins of the RV, providing a robust, predictive tool for modelling disease progression, intervention outcomes, and myocardial reserve remodelling.
Vibrissa-inspired control of the orientation of an array of end-effectors
Authors: Galperin Mark , Kleczka Kevin , Hartmann Mitra 
Published: February 2025

Abstract

The ability to precisely orient an array of end-effectors is critical for applications in robotics, sensing, and engineering. Inspired by the vibrissal (whisker) system of rodents, we introduce a novel mechanism that controls an arbitrary number of rotating joints using a single mechanical input with three planar degrees of freedom. The system comprises two rigid frames – a fixed frame and a movable control frame – interconnected by stiff rods, enabling both forward/backward rotations (“protraction”) and converging/diverging rotations (“fanning”). We derive analytic expressions relating the control frame’s position and orientation to end-effector angles, proving that each configuration is associated with a unique parabola. We also show that a coordinate transformation allows independent control of protraction and fanning. Hardware implementation demonstrates that the mechanism is functional and that it can be scaled without additional actuators. This bio-inspired approach provides a versatile, low-dimensional solution for orienting sensors and tools in dynamic environments.
The Interplay Between IL-6, Hepcidin, and BMPR2 Signalling in Pulmonary Arterial Hypertension: Mechanistic Insights into Vascular Remodelling
Authors: Toe Quezia K , Issitt Theo , Quinlan Gregory J , Wort S John 
Published: February 2025

Abstract

Pulmonary arterial hypertension (PAH) is characterized by excessive pulmonary vasoconstriction and vascular remodelling, with mutations in bone morphogenetic protein receptor type 2 (BMPR2) being the most common genetic alteration associated with the disease. While inflammatory mediators like interleukin-6 (IL-6) and the iron-regulatory hormone hepcidin have been implicated in vascular remodelling, their interaction with BMPR2 signalling remains poorly understood. This study investigated how IL-6 and hepcidin influence BMPR2 expression and downstream signalling in human pulmonary arterial endothelial cells (hPAECs). Using qPCR and Western blot analyses, we demonstrated that both IL-6 and hepcidin significantly reduced BMPR2 mRNA and protein levels in hPAECs. Intriguingly, despite this reduction, SMAD1/5 phosphorylation remained active, suggesting compensatory signalling through alternative receptor complexes. Treatment with IL-6 and hepcidin upregulated inhibitors of differentiation (ID) protein expression, mimicking the effects observed with BMPR2 knockdown. These findings reveal a novel regulatory axis involving IL-6, hepcidin, and BMPR2 in PAH pathogenesis, where IL-6 and hepcidin promote vascular remodelling through both BMPR2-dependent and independent mechanisms. These results suggest that therapeutic strategies targeting this axis, particularly those aimed at rebalancing BMP/TGF-β signalling, may hold promise for treating PAH.
Behavioral Determinants of Climate-Smart Agriculture Adoption among Smallholder Leafy Vegetable Agripreneurs in Semi-Arid Central Tanzania
Authors: ERICK STEPHEN BISHIBURA , Mbwambo Jonathan Stephen , Salanga Raymond 
Published: February 2025

Abstract

This study examines the behavioral determinants influencing the adoption of climate-smart agriculture (CSA) practices among smallholder leafy vegetable agripreneurs in semi-arid Central Tanzania. Guided by the Theory of Planned Behavior (TPB), the study investigates the role of attitudes, subjective norms, and perceived behavioral control in shaping CSA adoption, incorporating perceived usefulness as a mediating factor. Using a cross-sectional survey of 385 agripreneurs from Dodoma and Singida regions, data were analyzed using Structural Equation Modeling (SEM) in Smart PLS 4. The findings reveal that attitudes significantly influence perceived usefulness and CSA adoption, indicating that farmers who recognize the benefits of CSA are more likely to adopt these practices. Subjective norms and perceived behavioral control also play a crucial role, emphasizing the influence of social networks and access to resources. Perceived usefulness strongly mediates the relationship between behavioral determinants and adoption, underscoring its role in translating positive perceptions into action. The study highlights key policy implications, including strengthening agricultural extension services, improving financial access, and leveraging social networks to enhance CSA adoption. Despite limitations related to its cross-sectional design and reliance on self-reported data, the study offers valuable insights for policymakers, researchers, and development organizations. Future research should adopt longitudinal approaches and integrate objective farm-level assessments to deepen understanding of CSA adoption dynamics.
What do we know about wicked problems after nearly 52 years: A bibliometric analysis
Authors: Danaeefard Hassan , khosravi Mehdi 
Published: February 2025

Abstract

Wicked problems have become a crucial area of study across various fields. This research offers an extensive bibliometric analysis of the literature surrounding wicked problems, aiming to clarify the intellectual framework and development of this research domain. By using the bibliometrix package in R software and VOSviewer, the study explores factors such as annual publication trends, author influence, source importance, and the historical progression of the field through citation analysis, co-citation analysis, and thematic mapping. The findings reveal an increasing acknowledgment of wicked problems in areas like public policy, environmental science, and governance, especially since the mid-2010s. The keyword co-occurrence analysis identifies key themes, such as governance, complexity, collaborative governance, and sustainability. Thematic clusters indicate a continuous focus on collaborative governance, public policy, sustainable development, and climate change, highlighting the immediate relevance of current global challenges. Emerging topics, including the COVID-19 pandemic, green energy, and collaborative innovation, suggest a developing comprehension of the intricacies and urgency surrounding wicked problems. Furthermore, emerging concepts like super wicked problems, clumsy solutions, and joined-up government point to new paths for scholarly investigation, reflecting an adaptive response to modern global issues. Overall, the insights drawn from this bibliometric analysis provide a solid foundation for future research, offering valuable guidance for researchers and practitioners in formulating more holistic and effective approaches to address these urgent challenges.
Geospatial Technologies-based Priority Forest Restoration Areas Identification: A Systematic Literature Review
Authors: Teshager Zelalem , Soromessa Teshome 
Published: February 2025

Abstract

Forest resources have been declining due to various human activities, including agricultural expansion, selective logging, and overgrazing. To address this issue, restoration initiatives such as reforestation and afforestation have been introduced, with varying degrees of success. Site selection has emerged as a critical factor in determining the outcome of these initiatives. This review paper examines methods for identifying suitable restoration sites using remote sensing (RS), geographic information systems (GIS), and multi-criteria analysis (MCA), focusing on data sources, satellite imagery, and key criteria. A systematic review of 26 scientific research papers published between 1999 and 2022 was conducted. The analysis revealed that 81% of studies did not involve stakeholders in identifying priority areas for restoration, while 10% included only expert stakeholders. Approximately 70% of studies considered both ecological and socioeconomic criteria, with the remaining 30% focusing solely on ecological factors. Common ecological criteria included distance from existing forest patches, land use/land cover, slope, and proximity to water sources. Satellite imagery used for spatial data collection varied, with Landsat-7 (38.5%), SPOT (30.77%), Landsat-8 (19.23%), and IKONOS (11.54%) being the most frequently utilized. Datasets are mainly sourced from the United States Geological Survey (USGS) website, supplemented by additional open-source platform datasets. This review emphasizes the importance of a multidimensional approach to restoration, integrating ecological, socioeconomic, and political factors with advanced geospatial tools. The findings highlight the need for increased stakeholder involvement, utilization of open-source data, and adoption of holistic, inclusive planning methods to enhance the success of forest landscape restoration initiatives.
Revolutionizing Drug Development: Harnessing Artificial Intelligence in Pharmaceutical Sciences
Authors: Roy Samaresh Pal , Kadiri Sunil Kumar , Bhowmik Suchismita , Patel Vimal , Deb Lokesh , Tiwari Prashant 
Published: February 2025

Abstract:
The integration of artificial intelligence (AI) in pharmaceutical sciences marks a signifi-cant milestone in the field of drug discovery and development, presenting unique prospects for crea-tivity and productivity. This review article delves into the significant impact of AI on contemporary pharmaceutical practices, highlighting its incorporation in different phases of drug discovery and personalized medicine. Our goal is to offer a thorough analysis of the current landscape of AI appli-cations in the field, outline the extent of recent progress, and explore the obstacles and potential future paths for AI technologies. Significant advancements have been made in the drug development pro-cess, resulting in cost reduction and improved drug efficacy and safety profiling. In order to fully harness its potential, the various obstacles involved in the integration of AI must be overcome. These include ensuring the quality of data, navigating through regulatory requirements, and addressing eth-ical considerations. This review provides a comprehensive analysis of AI techniques, discussing the strengths and limitations of current technologies and identifying emerging trends that could poten-tially shape future pharmaceutical landscapes. Exploring the far-reaching effects of AI on healthcare, economics, and ethics, this analysis offers valuable insights into the potential of AI-driven strategies to revolutionize healthcare, making it more individualized and efficient. In the end, this review seeks to provide guidance to stakeholders in understanding the intricacies of AI in pharmaceutical sciences and utilizing its potential to improve patient outcomes.
Future Study of Factors Affecting Economic Poverty in Iran 2043: A Threat to Health
Authors: Faryabi Reza , Bordbar Shima , Amiri Mohammad Moqaddasi , Yusefi Ali Reza 
Published: February 2025

Introduction

Economic poverty is a fundamental challenge in many countries, significantly impacting human societies. Identifying and analyzing the numerous factors contributing to poverty is a practical approach to reducing its burden. Policymakers, equipped with knowledge of potential future scenarios, can formulate effective strategies and policies for various contingencies. This study uses a scenario-based planning approach to explore the factors influencing economic poverty in Iran by 2043.

Methods

The study was conducted in two phases. Phase one involved a comprehensive review to identify factors contributing to poverty. Phase two focused on determining key driving factors and forces, followed by the formulation of compatible scenarios through the analysis of mutual interactions and potential states of these factors. Data analysis and scenario creation were facilitated using MICMAC and Scenario Wizard software.

Results

In the first phase, 35 factors contributing to economic poverty were identified and categorized into micro-level (15 factors) and macro-level (20 factors). In the second phase, experts identified 11 key driving factors. Additionally, by analyzing the balanced mutual effects and employing MICMAC and Scenario Wizard software, six compatible scenarios were developed. These scenarios ranged from unfavorable trends exacerbating poverty to maintaining the status quo and favorable trends under existing sanctions.

Conclusion
According to the scenarios of the first group with a high probability of occurrence, nine factors (mismanagement, sanctions, conflict and war, low level or lack of education, accidents, and natural disasters, lack of jobs and sources of income, financial corruption, lack of growth and economic development and lack of support from the government and supporting institutions) of the 11 final factors affecting poverty in Iran 2043 will have an unfavorable situation. Therefore, poverty alleviation planning and policy-making to cover the existing deficiencies are suggested by focusing on these nine factors.
Recent Advances in The Chemistry of Oxadiazepine Derivatives: A Significant Leap in Synthetic Heterocycles and Biological Activity
Authors: Abu-Hashem Ameen A. , Hakami Othman , Amri Nasser , Mukhrish Yousef E. , Abdelgawad Ahmed A. M. , Yousif Mahmoud N. M. 
Published: February 2025

Abstract:
The oxadiazepine moiety and its derivatives are crucial in developing new drugs. Combined
with various compounds such as phthalazine, imidazole, pyrazole, indole, benzofuran, and
thiazolopyrimidine, they exhibit beneficial biological properties. Recent studies have made significant
progress in synthesizing oxadiazepine derivatives, enhancing our understanding of their potential
medicinal applications. This review offers a comprehensive overview of these advancements,
detailing the synthesis of various oxadiazepine derivatives and the chemical reactions involved.
Here are some examples of the compounds discussed in this review: 3,6-di-nitro-1,3,6-
oxadiazepane; 1,3,6-oxadiazepinodiphthalazine; 6-(1,3,6-oxadiazepane)-glycyl-L-alanine; benzoimidazo-
1,3,6-oxadiazepine; azepino[1,2-c][1,3,6]oxadiazepine; dipyrazolo-1,3,6-oxadiazepine;
sub-1,3,6-oxadiazepine-diindole; benzooxazino[3,4-b]benzo[5,6][1,4] oxazino[4,3-f][1,3,6]-
oxadiazepine-6,8-diol and 2-(2-chloroethyl)-11-methyl-1,3,6-oxadiazepino[3,4-a]indole derivatives.
These compounds are created through chemical reactions such as alkylation, condensation,
cyclization, coupling, substitution, oxidation, reduction, multi-component reactions, intramolecular
Mannich bases, and hydrolysis. Considering the significant biological activity of oxadiazepine derivatives,
which are found in certain drugs such as staurosporine, these synthetic methods facilitate
the efficient production of these compounds, thus encouraging further research into their potential
pharmaceutical applications.