bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Validation of the Pyroptosis-related genes Signature for Predicting the Prognosis of Colorectal Cancer
Authors: Zhou Kexun , Tan Huaicheng , Yu Ting , Liu Chunhua , Ding Zhenyu , Liu Jiyan , Shi Huashan 
Published: November 2021

Abstract
Background: Pyroptosis is an important component of the tumor microenvironment, associated with the occurrence and progression of cancer. However, the expression of pyroptosis-related genes and its impact on the prognosis of colon cancer (CC) remains unclear. Here, we constructed and validated a pyroptosis-related genes signature to predict the prognosis of patients with CC.Methods: Public data source was obtained to screen out candidate genes for further analysis. Various methods were combined to construct a robust pyroptosis-related genes signature for predicting the prognosis of patients with CC. Based on the gene signature and clinical features, a decision tree and nomogram were developed to improve risk stratification and quantify risk assessment for individual patients.Results: The pyroptosis-related genes signature successfully discriminated CC patients with high-risk in the training cohorts. The prognostic value of this signature was further confirmed in independent validation cohort. Multivariable Cox regression and stratified survival analysis revealed this signature was an independent prognostic factor for CC patients. The decision tree identified risk subgroups powerfully, and the nomogram incorporating the gene signature and clinical risk factors performed well in the calibration plots.Conclusions: Pyroptosis-related genes signature was an independent prognostic factor, and can be used to predict the prognosis of patients with CC.
A Shakedown Strength based Parametric Optimization Technique and its Application on an Airtight Module
Authors: Huang Songhua , Xu Yugong , Zhang Lele , Chen Geng , Liu Feng 
Published: November 2021

Abstract
In aerospace engineering, design and optimization of mechanical structures are usually performed with respect to elastic limit. Besides causing insufficient use of the material, such design concept fails to meet the ever growing needs of the light weight design. To remedy this problem, in the present study, a shakedown theory based numerical approach for performing parametric optimization is presented. Within this approach, strength of the structure is measured by its shakedown limit calculated from the direct method. The numerical method developed for the structural optimization consists of nested loops: The inner loop adopts the interior point method to solve shakedown problems pertained to fixed design parameters, while the outer loop employs the genetic algorithm to find optimal design parameters leading to the greatest shakedown limit. The method established is first verified by the classic plate-with-a-circular-hole example, and after that it is applied to an airtight module for determining few key design parameters. By carefully analyzing results generated during the optimization process, it is convinced that the approach can become a viable means for designing similar aerospace structures.
Kinesiophobia and Related Factors in Tumor Patients with Tiaps During the Long Term: A Cross-Sectional Survey
Authors: Wang Ya-wen , Qiu Xiao-Xia 
Published: November 2021

Abstract
Objective

This study is designed to investigate the status of kinesiophobia and related factors in tumor patients with the implanted port.
Methods

A total of 282 patients with the implanted port in the Oncology Department and the Daytime Chemotherapy Center in Ren ji Hospital, Shanghai Jiao Tong University School of Medicine, from April 1st,2021 to May 31༌2021 were selected for the interview by using the self-made general information questionnaire, TSK-11 scale.
Results

The TSK-11 score of the 282 patients was(17.84 ± 6.06)points, 45.7% of the patients reported some degree of kinesiophobia (TSK-11 ≥ 18), and 18.4% of the patients had scores rated as moderate to severe (TSK-11 ≥ 25), the highest score was 34 points. Logistic regression analysis results showed that exercise habits (P = 0.025), pain (P = 0.023) and foreign body sensation (P = 0.003) were the important factors of kinesiophobia.
Conclusion

The occurrence of kinesiophobia is common in tumor patients with the TIAP, and it is closely related to the subjective experience of daily activities, which requires more attention and early intervention to reduce the potential adverse effects.
SESR-based Identification of Flash Drought and Multivariate Drought Risk Probability Assessment in the Pearl River Basin, China
Authors: Chen Bei , Wu Chuanhao , Yeh Pat J.-F. , Li Jiayun , Lv Wenhan , Zhao Jin 
Published: November 2021

Abstract
Flash drought (FD) is characterized by the rapid onset and development of drought conditions. It usually occurs during the growing seasons, causing more severe impacts on agriculture and society than the slowly-evolving droughts. Based on the Standard Evaporative Stress Ratio (SESR), this study presents an assessment of the spatio-temporal variability of the joint return periods of FD characteristics in the Pearl River basin (PRB), southern China. Three FD characteristics (i.e., duration D, intensity I, peak P) are extracted at each 0.25o×0.25o grid point over the PRB by the Runs theory. Four marginal distribution functions (Gamma, Exponential, Generalized Extreme Value and Lognormal) are used to fit FD characteristics, while three Archimedean Copula functions (Clayton, Frank and Gumbel) are used for generating the joint distributions of various paired FD characteristics. The results indicate that Lognormal is the best-fitted marginal distribution function of FD characteristics in most parts of PRB, while Frank and Clayton are the best-fitted Copula of the joint PDFs of three pairs of FD characteristics in most parts of PRB. During 1953–2013, the FD events are more frequent in eastern PRB (> 40 events) than western PRB (<10 events), and larger FD characteristics (D and I) are also found in eastern PRB than western PRB. The return period of each FD characteristic is smaller in eastern PRB than western PRB, leading to smaller joint return periods of three paired FD characteristics (D-I, D-P, P-I) in eastern PRB than western PRB. Overall, our results suggest that the risk of FD is gradually increased from the west to the east of the PRB.
Junctionless Gate-All-Around Nanowire FET with Asymmetric Spacer for Continued Scaling
Authors: Vakkalak Bharath Sreenivasulu , Narendar Vadthiya 
Published: November 2021

Abstract
In this paper we have performed scaling performance of asymmetric junctionless (JL) SOI nanowire FET at 10 nm gate length (LG). To study the device electrical performance various DC metrics like SS, DIBL, ION/IOFF ratio are performed. Even at 5 nm, the device has good electrical properties with subthreshold swing (SS) = 64 mV/dec, drain induced barrier lowering (DIBL) = 45 mV/V, and switching ratio (ION/IOFF) = 106 shows a higher level of electrostatic integrity. Moreover, to study scaling flexibility towards analog/RF applications various parameters like transconductance (I), transconductance generation factor (TGF), total gate capacitance (Cgg), and cutoff frequency (fT) are determined. Furthermore, the dynamic power (DP) and static power (SP) consumption of the device with scaling is also presented. The findings of the study show that asymmetric JL nanowire FET is one of the scaling possibilities.
6G- Enabled Smart City Networking Model Using Lightweight Security Module
Authors: Kamruzzaman M. M. 
Published: November 2021

Abstract
Smart cities use lightweight security module technologies like sixth-generation (6G) and wireless connections to improve people's quality of life. A smart city can use a networking model to power and monitor many geographically distributed networking models to support various applications like energy and resource management, intelligent transportation systems, and e-health. To manage smart city resources efficiently and intelligently, a significant state architecture must service various technologies due to the enormous development in networking models and the amount of data they generate. This research work presents a smart city networking architecture for smart city environments employing the lightweight security module (SCNM-LSM) in this work in progress article. It first offers a new conceptual framework termed the conventional model for activity off-loading and resource allocation. Second, it enhances the standard model by including off-loading and resource allocation awareness. It expands on the specific research topics to create and study the effectiveness of individual components with the previous models to accommodate technological improvements like the use of Artificial Intelligence (AI) in the sixth generation data transmission technology.
The Association Between Neuroticism and Premenstrual Syndrome Symptoms.
Authors: Nosratabadi Soodeh , Ahmadi Atefeh , Ghazanfarpour Masumeh , Hosseinnataj Abolfazl , Khorasani Fahimeh 
Published: November 2021

Abstract
Background and objectives: Premenstrual syndrome includes physical and mental symptoms occurring cyclically during the secretory phase. The present study aimed to specify the association between neuroticism and the severity of premenstrual syndrome symptoms. Method: This cross-sectional study was conducted on 223 students of Kerman University of Medical Sciences in 2019 November 17. Chi-square and Fisher’s exact tests were used to analyze the relationship between qualitative variables; stepwise logistic regression was employed to assess the factors affecting the syndrome symptoms, and Mann–Whitney U test was used to compare the scores of the Daily Record of Severity of Problems chart in two groups. Findings: 223 female students completed the first stage information. The mean score of the questionnaire was 151.72±100.11. Moreover, 77.6% of the students had the syndrome. The severity of symptoms was mild, moderate, severe, and highly severe in 53.6, 42, 3.6, and 0.7%, respectively. There was a significant relationship between premenstrual syndrome and neuroticism scores. Students with PMS had higher scores in all of the subscales (neuroticism including anxiety, stress, despair,..) (P<0.001). Conclusion: It seems that there is a relationship between neuroticism (anxiety, stress, despair) and the severity of PMS symptoms. Therefore, it is recommended that therapists and counselors consider these factors to treat and mitigate the severity of PMS symptoms.
Morpho-molecular Identification and Chemical control of Alternaria alternata,causing leaf blight of Gardenia jasminoides Eills in China
Authors: Zhao Anna , Gong Yuhong , Luo Guangming , Luo Yangjin , Song Dandan , Xia Hongdong 
Published: November 2021

Abstract
Gardenia jasminoides Eills is a traditional aromatic and medicinal plant that is widely cultivated in China. In 2020, a severe leaf disease on Gardenia was observed in a growing herbal medicine area in Jian County, of Jiangxi Province, China. The causal agent was identified as Alternaria alternata (Fr.) Keissler. by amplification and sequencing the internal transcribed spacer (ITS) region, followed by phylogenetic analysis. Koch's postulates were confirmed by a pathogenicity test conducted with healthy gardenia, including reisolation and identification. To our knowledge, this is the first report of leaf blight caused by Alternaria alternata on Gardenia jasminoides Eills in JiangXi, China. PDA plate bacteriostatic experiment results showed that: Hexaconazole had the best inhibiting effect, which the EC 50 was 14.45 ppm. Therefore, the results are preliminary but promising for future field applications.
The Potential circRNAs in Imatinib Resistance of GIST
Authors: Yan Jingyi , Chen Xiaolei , Dong Qiantong , Lin Ji , Sun Xuecheng 
Published: November 2021

Abstract
Background: Circular RNAs are a recently (re-)discovered abundant RNA species, belongs to part of the competing endogenous RNA network(ceRNA), Which was proved to play a critical role in the development, diagnosis and progress of diseases. Methods: We analyzed the expression of circular RNAs in paired normal gastric tissues(N), primary GIST (gastrointestinal stromal tumor) tissues (Y or YC) and imatinib mesylate secondary resistance GIST tissues(C) with microarray and predicted 8677 dysregulated circular RNAs. Results: We identified 15 circRNAs was up-regulated and 8 circRNAs were down-regulated in C group. Gene ontology (GO)and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis identified that the host linear transcripts of these differentially expressed circRNAs were involved in many critical biological pathways and molecular functions, predicting the potential tumor-genesis and drug resistance mechanism was related with HIF-1 pathway, later we draw the cirRNA-miRNA-mRNA network involved in the HIF-1 pathway, found that several dysregulated circRNAs and the relationship between circRNA-miRNAs-mRNA, such as circRNA_06551, circRNA_14668, circRNA_04497, circRNA_08683, circRNA_09923(Green, down-regulation) and circRNA_23636, circRNA_15734(Red, up-regulation). Conclusions: Taken together, we identified a panel of dysregulated circRNAs that may be potential biomarkers even therapy relevant to the GIST, especially imatinib secondary resistance GIST.
Tick-Borne Encephalitis Affects Sleep-Wake Behavior and Locomotion in Infant Rats
Authors: Chiffi Gabriele , Grandgirard Denis , Stöckli Sabrina , Valente Luca G. , Adamantidis Antoine R. , Leib Stephen L. 
Published: November 2021

Abstract
Background/Aims: Tick-borne encephalitis (TBE) is a disease affecting the central nervous system. Over the last decade, the incidence of TBE has steadily increased in Europe and Asia despite the availably of effective vaccines. Up to 50% of patients after TBE suffer from post-encephalitic syndrome that may develop into long-lasting morbidity. Altered sleep-wake functions have been reported by patients after TBE. The mechanisms causing these disorders in TBE are largely unknown to date. As a first step toward a better understanding of the pathology of TBEV-inducing sleep dysfunctions, we assessed parameters of sleep structure in an established infant rat model of TBE.Methods: 13-day old Wistar rats were infected with 1 x 106 FFU Langat virus (LGTV). On day 4, 9, and 21 post infection, Rotarod (balance and motor coordination) and open field tests (general locomotor activity) were performed and brains from representative animals were collected in each subgroup. On day 28 the animals were implanted with a telemetric EEG/EMG system. Sleep recording was continuously performed for 24 consecutive hours starting at day 38 post infection and visually scored for Wake, NREM, and REM in 4 seconds epochs.Results: As a novelty of this study, infected animals showed a significant larger percentage of time spend awake during the dark phase and less NREM and REM compared to the control animals (p < 0.01 for all comparisons). Furthermore, it was seen, that during the dark phase the wake bout length in infected animals was prolonged (p = 0.043) and the fragmentation index decreased (p = 0.0085) in comparison to the control animals. LGTV-infected animals additionally showed a reduced rotarod performance ability at day 4 (p = 0.0011) and day 9 (p = 0.0055) and day 21 (p = 0.0037). A lower locomotor activity was also seen at day 4 (p = 0.0196) and day 9 (p = 0.0473). Conclusion: Our data show that experimental TBE in infant rats affects sleep-wake behavior, leads to decreased spontaneous locomotor activity, and impaired moto-coordinative function.
The GnRH Antagonist Protocol is Associated with a Higher Embryo Aneuploidy Rate Than the GnRH Agonist Long Protocol in Chinese Women
Authors: Wang Jun , Zhang Jing , Zhao Nan , Ma Yuan , Wang Xiyi , Gou Xingqing , Ju Ying , Zhang Hengde , Chen Shuqiang , wang Xiaohong 
Published: November 2021

Abstract
Background: Studies in oocytes have suggested increased aneuploidy rates after ovulation induction in mammals and humans. Conversely, some studies have shown that ovarian stimulation does not significantly increase the embryo aneuploidy rate in humans compared with an unstimulated cycle. In addition, the potential effect of the gonadotropin-releasing hormone (GnRH) antagonist (GnRH-ant) protocol and GnRH agonist (GnRH-a) long protocol on embryo aneuploidy remains unknown.Methods: This is the retrospective cohort study from university-affiliated fertility center. In total, 578 early miscarriage patients who conceived through IVF/intracytoplasmic sperm injection (ICSI) after receiving the gonadotropin-releasing hormone (GnRH) antagonist (GnRH-ant) protocol or the GnRH agonist (GnRH-a) long protocol were analyzed to compare the aneuploidy rates in early aborted tissues. In addition, a total of 466 preimplantation genetic testing for aneuploidy (PGT-A) cycles undergoing GnRH-ant protocol or GnRH-a long protocol were also analyzed to compare the aneuploidy rates in embryo.Results: For early miscarriage patients who conceived through IVF/ICSI, compared to the GnRH-a long protocol group, the GnRH-ant protocol group had a significantly higher rate of aneuploidy in early aborted tissues (48.70% vs. 64.52%), and increased aneuploidy was associated with a significantly higher incidence of trisomy 13, 18, and 21 (p<0.01). Regarding PGT-A cycles, compared to the GnRH-a long protocol group, the rate of embryo aneuploidy was also significantly higher in the GnRH-ant protocol group (48.01% vs. 58%). After stratification and multiple linear regression, the GnRH-ant regimen remained significantly associated with an increased risk of aneuploidy in early aborted tissues and embryos [OR (95% CI) 1.767 (1.174, 2.661), OR (95% CI) 1.465 (1.020, 2.102)]. Furthermore, the embryo aneuploidy rate in the GnRH-ant protocol group was significantly higher than that in the GnRH-a long protocol group but only in young and normal ovarian responders [OR (95% CI) 3.54 (1.48, 8.46)].Conclusions: The GnRH-ant protocol is associated with a higher aneuploidy rate in early aborted tissues and embryos than the GnRH-a long protocol in Chinese women. A multicenter, randomized controlled trial would be the optimal strategy to confirm these results.
Characterization of The Prognostic m6A-Related lncRNA Signature For Predicting Immune Responses In Esophageal Cancer
Authors: Zhang Qin , Zhang Luyan 
Published: November 2021

Abstract
Background: This study aimed to construct a long non-coding RNAs (lncRNAs) signature related to N6-methyladenosine, so as to precisely forecast the prognosis of esophageal cancer patients. Methods: In this study, we downloaded RNA inference data and test data of patients with Erson skin color from the TCGA database, and passed skin-related tests, single-variation coxs and selection operator (LASSO) Cox regression to all subjects related to the subtypes and risks The results were analyzed for survival and predicted with different properties and values of risk models. Finally, we also discussed the potential immunotherapeutic characteristics and drug sensitivity prediction of the model.Results: Firstly, 93 lncRNAs related to prognosis were obtained through co-expression and univariate Cox analysis. Then we also performed least absolute shrinkage and selection operator (LASSO) analysis to obtain AC012467.2, AL161891.1,ARHGAP27P1-BPTFP1-KPNA2P3,LINC00930,POLR2J4, AP003696.1，AP003696.1 and MAGI1-AS1 to construct m6A-related lncRNA model. The subsequent consensus clustering analysis divided these samples into two parts. We observed that the survival curves of patients from different clusters and risk groups were significantly different. With the help of Kaplan-Meier survival analysis and ROC curve, we confirmed the difference of survival rates among different risk groups, and proved the prognostic value of risk signals, We observed that there were significant differences in the characteristics of immunotherapy between high-risk and low-risk groups, including the immune cell infiltration, immune gene expression, immunosuppressive points, and drug sensitivity. Conclusions: m6A-related lncRNAs prognostic signature was shaped that probably functions as vital mediators of tumor microenvironment of esophageal cancer, and might become underlying biomarkers to forecast the prognosis of esophageal cancer patients.
Pan-Cancer Analysis of the Carcinogenic Effect of Nuclear Respiratory Factor-1 (NRF1) in Human Tumors
Authors: Jiang Yong , Chang Yaodan , Sun Jiahui , Sun Yanping , Yang Chunjuan , Kuang Haixue , Wang Zhibin 
Published: November 2021

Abstract
Despite there are many cellular or animal experiments that support a link between NRF1 and cancer, there is currently no pan-cancer analysis available. Therefore, the source of data is TCGA and GEO, we explored the potential role of NRF1 in 33 kinds of tumors. The expression of NRF1 is significantly increased in most tumors, and the expression of NRF1 is correlated to the prognosis of tumor patients. We discovered that the expression level of NRF1 in PAAD was correlated to immune infiltration. The methylation of NRF1 increased significantly in KIRC, PAAD, ACC. In addition, RNA metabolic pathway or cell biology-related functions participate in the functional mechanism of NRF1.Our research provides a comprehensive explanation of the pathogenic effects of NRF1 in related tumors.
Outcome of Transverse Patella Fractures Fixed With Cannulated Screws and Stainless Steel Tension Band Wiring
Authors: Abdel-Moneim Haytham Abdel-Moneim , Moussa Mohammed Ahmed 
Published: November 2021

Abstract
Background: Tension band supplemented by K-wires has long been the definitive technique for patellar fractures fixation. However, it is not without drawbacks. The stainless streel cable-cannulated screw tension band technique, may shorten healing time, decrease the complications and provide early range of knee motion. Herein, the current study evaluates the clinical and radiological outcome of this surgical modality. Methods: This prospective study was conducted on 21 patients (13 males and 8 females) with transverse fracture patella from June 2017 to April 2021. The surgical fixation consisted of two 4.0-mm parallel partially threaded cannulated cancellous screws with a figure-of-eight stainless steel tension band wiring. Follow-up was at least 10 months. Assessment criteria included the Lysholm score for knee function, ROM, VAS for pain, fracture reduction, fracture healing time, and complication rates. After 3 postoperative weeks, slab was removed and immediate rehabilitation were commenced.Results: The average Lysholm scores were 82.9 ± 4.4 SD, 87.8 ± 5.3 SD, and 92.7 ± 3.6 SD after 3, 6, and 10 months, respectively. VAS scores for pain were 2.6 ± 3.0 SD, 1.4 ± 2.6 SD, and 0.5 ± 2.3 SD at 3, 6 and 10-month, respectively. The patients had gained total ROM after 3, 6 and 10 months. The mean fracture healing time was 2.1 months (range, 1.5 - 3.1 months). Two patients experienced skin irritation by wire tails.Conclusion: The stainless steel cannulated screws and tension band construct provides a good alternative in treatment of transverse patellar fractures. It could yield stable fixation, low complication rate while providing early mobilization and accelerated rehabilitation.