bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Far Ultraviolet Spectroscopic Explorer Survey of Interstellar Molecular Hydrogen in the Galactic Disk
Authors: Shull J. Michael , Danforth Charles W. , Anderson Katherine L. 
Published: April 2021

Abstract
We report results from a Far Ultraviolet Spectrographic Explorer (FUSE) survey of interstellar molecular hydrogen (H2) in the Galactic disk toward 139 O-type and early B-type stars at Galactic latitudes ∣b∣ ≤ 10°, with updated photometric and parallax distances. H2 absorption is measured using the far-UV Lyman and Werner bands, including strong R(0), R(1), and P(1) lines from rotational levels J = 0 and J = 1 and excited states up to J = 5 (sometimes J = 6 and 7). For each sight line, we report column densities N
H2, N
HI, N(J), and N
H = N
HI + 2N
H2 and the molecular fraction f
H2 = 2N
H2/N
H. Our survey extends the 1977 Copernicus H2 survey up to N
H ≈ 5 × 1021 cm−2. The lowest rotational states have excitation temperatures and rms dispersions 〈T
01〉 = 88 ± 20 K and 〈T
02〉 = 77 ± 18 K, suggesting that J = 0, 1, 2 are coupled to the gas kinetic temperature. Populations of higher-J states exhibit mean excitation temperatures 〈T
24〉 = 237 ± 91 K and 〈T
35〉 = 304 ± 108 K, produced primarily by UV radiative pumping. Correlations of f
H2 with E(B − V) and N
H show a transition to f
H2 ≥ 0.1 at N
H ≳ 1021 cm−2 and E(B − V) ≳ 0.2, interpreted with an analytic model of H2 formation–dissociation equilibrium and attenuation of the far-UV radiation field by self-shielding and dust opacity. Results of this disk survey are compared to previous FUSE studies of H2 in translucent clouds, at high Galactic latitudes, and in the Magellanic Clouds. Using updated distances to the target stars, we find average sight-line values 〈f
H2〉 = 0.20 and 〈N
H/E(B − V)〉 = 6.07 × 1021 cm−2 mag−1.
Development and Validation of 3 Preliminary MRI Sacroiliac Joint Composite Structural Damage Scores in a 5-year Longitudinal Axial Spondyloarthritis Study
Authors: Wetterslev Marie , Østergaard Mikkel , Sørensen Inge J. , Weber Ulrich , Loft Anne G. , Kollerup Gina , Juul Lars , Thamsborg Gorm , Madsen Ole R. , Møller Jakob M. , Pedersen Susanne J. 
Published: April 2021

Objective.In axial spondyloarthritis (axSpA), sacroiliac joint (SIJ) erosion is often followed by fat metaplasia in an erosion cavity (backfill), and subsequently ankylosis. We aimed to combine the Spondyloarthritis Research Consortium of Canada (SPARCC) SIJ structural score for erosion, backfill, and ankylosis into 3 versions of a novel preliminary axSpA magnetic resonance imaging (MRI) SIJ Composite Structural Damage Score (CSDS) and to test these.Methods.Thirty-three patients with axSpA, followed for 5 years after initiation of tumor necrosis factor inhibitor, had MRIs of the SIJs at baseline, and yearly thereafter. Three versions of CSDS were calculated based on different weightings of erosion, backfill, and ankylosis: (1) equal weighting: CSDSequal = (erosion × 0.5) + backfill + ankylosis; (2) advanced stages weighting more: CSDSstepwise = (erosion × 1) + (backfill × 4) + (ankylosis × 6); and (3) advanced stages overruling earlier stages (“hierarchical”) with “<” meaning “overruled by”: CSDShierarchical = (erosion × 1) < (backfill × 4) < (ankylosis × 6).Results.At baseline, all CSDS correlated positively with SPARCC fat and ankylosis scores and modified New York radiography grading, and negatively with the Bath Ankylosing Spondylitis Disease Index and SPARCC SIJ inflammation scores. CSDSstepwise and CSDShierarchical (not CSDSequal) correlated positively with symptom duration and the Bath Ankylosing Spondylitis Metrology Index, and closer with SPARCC ankylosis score and modified New York radiography grading than CSDSequal. The adjusted annual progression rate for CSDSstepwise and CSDShierarchical (not CSDSequal) was higher the first year compared with fourth year (P = 0.04 and P = 0.01). Standardized response mean (baseline to Week 46) was moderate for CSDShierarchical (0.64) and CSDSstepwise (0.59) and small for CSDSequal (0.25).Conclusion.Particularly CSDSstepwise and CSDShierarchical showed construct validity and responsiveness, encouraging further validation in larger clinical trials. The potential clinical implication is assessment of SIJ damage progression by 1 composite score.
Effects of Denosumab in Japanese Patients With Rheumatoid Arthritis Treated With Conventional Antirheumatic Drugs: 36-month Extension of a Phase III Study
Authors: Tanaka Yoshiya , Takeuchi Tsutomu , Soen Satoshi , Yamanaka Hisashi , Yoneda Toshiyuki , Tanaka Sakae , Nitta Takaya , Okubo Naoki , Genant Harry K. , van der Heijde Désirée 
Published: April 2021

ObjectiveTo evaluate the safety and efficacy of long-term denosumab 60 mg every 6 months (Q6M) or every 3 months (Q3M) in patients with rheumatoid arthritis (RA).MethodsThis 12-month, randomized, double-blind, placebo-controlled, multicenter, phase III trial with an open-label extension period from 12 to 36 months (DESIRABLE) enrolled Japanese patients with RA treated with placebo (P) for 12 months followed by either denosumab Q6M (P/Q6M) or denosumab Q3M (P/Q3M) for 24 months; denosumab Q6M for 36 months (Q6M/Q6M); or denosumab Q3M for 36 months (Q3M/Q3M). Efficacy was assessed by van der Heijde modified total Sharp score (mTSS), bone erosion score (BES), and joint space narrowing (JSN) score.ResultsLong-term treatment better maintained mTSS and BES suppression in the P/Q3M and Q3M/Q3M vs P/Q6M and Q6M/Q6M groups; changes from baseline in total mTSS (standard error) at 36 months were 2.8 (0.4) and 1.7 (0.3) vs 3.0 (0.4) and 2.4 (0.3), respectively, and corresponding changes in BES were 1.3 (0.2) and 0.4 (0.2) vs 1.4 (0.2) and 1.1 (0.2), respectively. No JSN effect was observed. Bone mineral density consistently increased in all groups after denosumab initiation, regardless of concomitant glucocorticoid administration. Serum C-terminal telopeptide of type I collagen decreased rapidly at 1 month postdenosumab administration (in both the initial 12-month [Q3M and Q6M groups] and long-term treatment [P/Q3M and P/Q6M groups] phases). Adverse event incidence leading to study drug discontinuation was similar across treatment groups.ConclusionDenosumab treatment maintained inhibition of progression of joint destruction up to 36 months. Based on effects on BES progression, higher dosing frequency at an earlier treatment stage may be needed to optimize treatment. Denosumab was generally well tolerated. (ClinicalTrials.gov: NCT01973569).
Comparison of Men and Women With Axial Spondyloarthritis in the US-based Corrona Psoriatic Arthritis/Spondyloarthritis Registry
Authors: Mease Philip J. , McLean Robert R. , Dube Blessing , Liu Mei , Rebello Sabrina , Glynn Meghan , Yi Esther , Park Yujin , Ogdie Alexis 
Published: April 2021

ObjectiveTo compare patient characteristics and disease burden between men and women with axial spondyloarthritis (axSpA) in the US-based Corrona Psoriatic Arthritis/Spondyloarthritis (PsA/SpA) Registry.MethodsPatients aged ≥ 18 years with axSpA enrolled in the Corrona PsA/SpA Registry between March 2013 and November 2018 who were not concurrently diagnosed with PsA were included. Patient demographics, clinical characteristics, disease activity, patient-reported symptoms, work productivity, and treatment history at enrollment were compared between men and women, using t tests or Wilcoxon rank-sum tests for continuous variables and chi-square or Fisher exact tests for categorical variables.ResultsOf 498 patients with axSpA and available sex information, 307 (61.6%) were men and 191 (38.4%) were women. Compared with men, women had higher disease activity as measured by Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, and physician global assessment, and had higher tender/swollen joint counts and enthesitis scores (all P ≤ 0.01). Women also had worse patient-reported symptoms (pain, fatigue, Health Assessment Questionnaire for the Spondyloarthropathies, and EuroQol visual analogue scale; all P < 0.05), had greater work and activity impairment, and were less likely to work full time than men. Prior conventional synthetic disease-modifying antirheumatic drug and prednisone use was more common in women than in men (both P < 0.05). Additionally, women were more likely to have diagnoses of depression and fibromyalgia (both P < 0.01).ConclusionIn this US registry of patients with axSpA, women had higher overall disease burden and more peripheral manifestations than men. Improved awareness of sex differences in the presentation of axSpA may aid physicians in earlier identification and improved disease management.
La posture psynodique
Authors: Brissaud Frédéric 
Published: April 2021

La posture psynodique est une attitude d’accompagnement présentant six caractéristiques essentielles : imprévisibilité, ouverture, respect, doute, humilité et asymétrie. Radicalement différente de la posture finaliste, caractérisée par les notions d’objectif, de planification, d’évaluation et d’efficacité, la distinction psynodique/finaliste explicite une ligne de démarcation des pratiques réelles. Mise à jour par l’observation de gestalt-thérapeutes, il est probable que des pratiques de praticiens se réclamant d’autres méthodes présentent, elles aussi, ces six caractéristiques essentielles.
Le fil d’Antigone
Authors: Petit Mélanie 
Published: April 2021

Hegel qualifiait la pièce Antigone de Sophocle de tragédie la plus parfaite. Peut-on, encore aujourd’hui, malgré les critiques ultérieures, soutenir cette idée et la fonder ? Si la perfection de cette tragédie tient dans le tissage de conflits que Sophocle construit, nous devrons d’abord effiler chaque conflit, pour ensuite affilier chaque position à ce qui la fonde, et suivre enfin le déroulé tragique du fil d’Antigone.
Les grands travaux du PAEE d’Oran : esthétique urbaine et fabrique de la ville par le logement
Authors: Taibi Sofiane 
Published: April 2021

La production du logement social en France des années 1930 correspond à une époque où une nouvelle génération de penseurs de la ville, les urbanistes, élaborent pour la première fois des Plans d’Aménagement d’Embellissement et d’Extension (PAEE) pour les agglomérations françaises et qui vont traverser la méditerranée. Oran, ville dont la première extension se fait pendant l’application de la loi Cornudet et de la politique des Habitations à Bon Marché (HBM), constitue un bon exemple de cette orientation. Nous présentons dans cette contribution une analyse urbanistique des travaux de réalisation du PAEE d’Oran et de l’expérience des HBM de Choupot. L’objectif ici est de vérifier l’hypothèse suivante : la première extension d’Oran s’est faite dans un contexte favorable à l’expérimentation, visant l’homogénéisation de la ville et sa continuité urbaine à travers la conception et la réalisation du logement et son prolongement de l’habitat. Classification JEL : R21, R38, R52.
L’entrepreneuriat des femmes dans l’économie sociale et solidaire : une synthèse des points de vue des entrepreneures
Authors: Cauwet Sophie 
Published: April 2021

Les données chiffrées indiquent que, parmi les salariés de l’économie sociale et solidaire, la part des femmes est majoritaire. Pourtant, plus l’échelle des responsabilités augmente, moins les femmes y sont représentées. Se pose donc la question des motivations de celles qui entreprennent dans l’économie sociale et solidaire. Est-ce le fruit du « hasard » ? Un choix assumé ? Une voie volontairement empruntée ? Au sein des structures qu’elles dirigent, ces entrepreneures agissent et réagissent sur un terrain mouvant. Elles « mènent la barque » par une dynamique collective en conciliant les impératifs liés à l’équilibre économique mis au service de l’utilité sociale. Elles cherchent à mettre en œuvre des stratégies et des logiques d’action pour garder le cap et atteindre un but. Quelles sont-elles ? L’aventure est faite de hauts et de bas, mais elle fait grandir. Les entrepreneures peuvent compter pour cela sur des ressources, internes et externes. Elles peuvent également compter sur des compétences qu’elles mettent au service de l’entreprise, et/ou qu’elles développent avec l’expérience. Ici, différentes entrepreneures se livrent, et témoignent.
La fabrique du consensus autour du « gaz de couche de charbon » en France : analyse « archéologique » des discours d’appui à un projet extractif
Authors: Stein Marieke 
Published: April 2021

L’article vise à comprendre et à décrire les phénomènes discursifs qui expliquent qu’un projet d’extraction de Coal Bed Methane (un hydrocarbure voisin du gaz de schiste) ne soit que peu contesté, en France, alors que dans les pays où il est déjà exploité, cet hydrocarbure suscite de vives controverses. En effet, les discours (politiques, institutionnels, médiatiques, parfois même scientifiques…) qui circulent sur ce sujet dans l’espace public français véhiculent une vision unanimement favorable du projet extractif. La méthode ici proposée est celle d’une « archéologie » des discours qui circulent dans les différentes arènes en interaction. Cette analyse « archéologique » se caractérise par une attention particulière à des dynamiques d’élaboration et de transformation des discours dans le temps, et vise à découvrir, sous les énoncés qui véhiculent aujourd’hui une représentation univoque de l’activité extractive, les énoncés originels. La description des processus qui permettent l’envahissement des discours publics par les seuls énoncés doxiques mis en circulation par l’entreprise gazière à l’origine du projet, grâce à une analyse sémio-argumentative de la quasi-totalité des discours qui circulent autour de cette extraction dans les espaces publics légitimés, éclaire la « fabrique du consensus » par une analyse en diachronie des discours en interaction (discours entrepreneurial, militant, politique, institutionnel, de légitimation et oppositionnel…), de leurs trajectoires et de leurs métamorphoses.
Phenotypic and Clonal Stability of Antigen-Inexperienced Memory-like T Cells across the Genetic Background, Hygienic Status, and Aging
Authors: Moudra Alena , Niederlova Veronika , Novotny Jiri , Schmiedova Lucie , Kubovciak Jan , Matejkova Tereza , Drobek Ales , Pribikova Michaela , Stopkova Romana , Cizkova Dagmar , Neuwirth Ales , Michalik Juraj , Krizova Katerina , Hudcovic Tomas , Kolar Michal , Kozakova Hana , Kreisinger Jakub , Stopka Pavel , Stepanek Ondrej 
Published: April 2021

Abstract
Ag-inexperienced memory-like T (AIMT) cells are functionally unique T cells, representing one of the two largest subsets of murine CD8+ T cells. However, differences between laboratory inbred strains, insufficient data from germ-free mice, a complete lack of data from feral mice, and an unclear relationship between AIMT cells formation during aging represent major barriers for better understanding of their biology. We performed a thorough characterization of AIMT cells from mice of different genetic background, age, and hygienic status by flow cytometry and multiomics approaches, including analyses of gene expression, TCR repertoire, and microbial colonization. Our data showed that AIMT cells are steadily present in mice, independent of their genetic background and hygienic status. Despite differences in their gene expression profiles, young and aged AIMT cells originate from identical clones. We identified that CD122 discriminates two major subsets of AIMT cells in a strain-independent manner. Whereas thymic CD122LOW AIMT cells (innate memory) prevail only in young animals with high thymic IL-4 production, peripheral CD122HIGH AIMT cells (virtual memory) dominate in aged mice. Cohousing with feral mice changed the bacterial colonization of laboratory strains but had only minimal effects on the CD8+ T cell compartment, including AIMT cells.
The Influence of Reminder Book to Adherence of Heart Failure Patients in Malang City
Authors: Hany Alfrina , Fadlila Rizqa , Lydia Endah Panca 
Published: April 2021

Background Non-adherence to the recommended therapy causes patients with heart failure to experience recurrence of the disease. Reminder book on therapy adherence is very useful, because it assists in monitoring adherence to therapy carried out by patients while at home. Therefore, this study aims to determine the effect of the existence of a reminder book on adherence to therapy among patients with heart failure in a private hospital in Malang. Design and methods A pre-experiment design with one-group pre and posttest was used. The respondents were 18 patients that received counseling on the management of heart failure therapy while at home and were given a reminder book. Furthermore, the modified MMAS-8 scale was the study instrument used to measure adherence. Result The results showed that most respondents were above the age of 65 with a treatment duration of 1 to 5 years. It was discovered that most of the respondents had never received information about heart failure therapy. Data analysis which was carried out using the Wilcoxon test with a p-value of 0.001, showed that there was a significant difference between respondents’ compliance before and after being given a reminder book. Conclusions From this study, it was concluded that providing a reminder book has an effect on therapeutic adherence in patients with heart failure. Researchers recommend that hospitals should make use of this reminder as a tool to control or supervise outpatient therapy.
The Effectiveness of Home-Based Nursing Intervention in the Elderly with Recurrent Diabetic Foot Ulcers: A Case Report
Authors: Wuri Kartika Annisa , Widyatuti Widyatuti , Rekawati Etty 
Published: April 2021

Background Inadequate glycemic control usually leads to peripheral neuropathy, vasculopathy, and foot deformities that leads to diabetic foot ulcer (DFU), and a 10-years history of diabetes and inadequate self-management increases the risk of reoccurring DFU. A home-based intervention program, which includes Diabetes Self-Management Education (DSME) and wound care is the most likely approach, to engage families and overcoming the barriers in self-care management. The aim of this study is to provide an overview on the effectiveness of home-based nursing intervention in the elderly patients with reoccurring diabetic foot ulcers. Design and method In this study, a case study approach was used that presented a case related to self-management and wound care in elderly patients with reoccurring DFU. The intervention was carried out by the community health nurses for eight weeks with home visit. Results Significant changes were reported in diabetes selfmanagement practices, blood glucose level, and wound healing. The Diabetes Self-Management Questionnaire (DSMQ) score increased from 5.62 to 8.,54 and the Summary of Diabetes Self- Care Activities (SDSCA) score increased from 3.2 to 6. The Bates Jansen Examination score decreased from 24 and 26 to 17 and 14 in six weeks. Conclusions The results confirm that family-based interventions program are effective in improving glycemic control and wound healing. Community nursing is believed to prevent an increase in self-management behavior to prevent recurring DFU and maintain a healthy life-style about diabetes self-management education.
High-Fructose Diet Initially Promotes Increased Aortic Wall Thickness, Liver Steatosis, and Cardiac Histopathology Deterioration, but Does Not Increase Body Fat Index
Authors: Handayani Dian , Febrianingsih Erlinda , Desi Kurniawati Adelya , Kusumastuty Inggita , Nurmalitasari Shafira , Widyanto Rahma Micho , Oktaviani Diah Novida , Maghfirotun Innayah Alma , Sulistyowati Etik 
Published: April 2021

Background Dietary fats and fructose have been responsible for inducing obesity and body tissues damage due to the consequence of metabolic syndrome through several mechanisms. The body fat index (BFI) is one of the anthropometric measures used to detect obesity in rats. This study aims to examine the correlation between high-fat high-fructose diet and liver steatosis cell count, early atherosclerosis characteristics, and body fat index (BFI) in Sprague Dawley rats. Design and methods This was an experimental design using 2 groups of 12-weeks-old Sprague Dawley (SD) rats. The control group received a standard diet and tap water beverages for 17 weeks. The intervention group was fed with high-fat diet from modified AIN 93-M and additional 30% fructose drink. We analyzed the foam cell count, aortic wall thickness, cardiac histopathology, and liver steatosis cell count after the sacrifice process. Results The rats in the intervention group had a higher aortic wall thickness, liver steatosis, and foam cell count (+125%, p<0.01; +317%, p<0.01 and +165%, p<0.01 respectively) compared to the control group. The intervention group also showed higher mononuclear inflammatory and hypertrophic cell count. A significant positive correlation was found between dietary fructose with premature atherosclerosis by increasing foam cell count (r=0.66) and aortic wall thickness (r=0.68). In addition, 30% dietary fructose increased liver steatosis (r=0.69) and mononuclear inflammatory cardiac cell count (r=0.61). Interestingly, the intervention had no effect on the body fat index (p>0.5; r=0.13). Conclusions Dietary fat and fructose consumption for 17 weeks promotes atherosclerosis, liver steatosis, and cardiac histopathology alteration without increasing BFI.
The Needs of Traumatic Brain Injury Survivors' Caregivers and the Implication Required during the Covid-19 Pandemic: Public Health Issues
Authors: Othman Hamidah , Ludin Salizar Mohamed , Saidi Sanisah , Awang Mohamed Saufi 
Published: April 2021

Background Traumatic brain injury (TBI) survivors require attention and dependence from their primary caregiver. This is because TBI is a defect that affects both the psychological and physical functions of the victim. Caregivers play an essential role in providing the adequate care victims need to adjust to the new problems they may experience due to their condition, as family members alone may not be able to provide for their needs. In particular, TBI caregivers may face specific challenges when assisting their patients in handling unexpected changes to their daily routines. Therefore, this quantitative study aims to explore the needs of caregivers, their coping mechanisms towards stressful and traumatic circumstances, and how they provide care to their loved ones during the COVID-19 pandemic. Design and Methods It was conducted with ten caregivers of individuals suffering from traumatic brain injury, that were selected using a theoretical sampling method. Data were obtained using a semi-structured interview guide, which helped the caregivers provide their responses. Meanwhile, data analysis was performed using the NVIVO analysis software. Results The results showed that there were, three significant themes namely, (a) Support needed, (b) the information need for care, and (c) developing self-resilience. The results also showed that caregivers really need support from the various parties, and the participants lack information on specific care techniques for the severe traumatic brain injury (TBI) survivors. Conclusions: In conclusion, caregivers require approval and seek more useful information to provide excellent care to their loved ones. Being aware of the caregiver's needs would enable them to offer improved customized care.