bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of radiotherapy impact on survival in resected stage I/II pancreatic cancer patients: a population-based study
Authors: Han Dong , Gao Fei , Liu JinLong , Wang Hao , Fu Qi 
Published: April 2021

Abstract
Background: The application of radiotherapy (RT) in pancreatic cancer remains controversial. Aim: The aim of the study was to evaluate the efficacy of radiotherapy (neoadjuvant and adjuvant radiotherapy) for resectable I/II pancreatic cancer. Methods: 14977 patients with pancreatic cancer were identified from SEER database from 2004 to 2015. Multivariate analyses were performed to determine factors including RT on overall survival. Overall survival and overall mortality among the different groups were evaluated using the Kaplan-Meier method and Gray’s test. Results: Patients were divided into groups according to whether they received radiotherapy or not. The median survival time of all 14977 patients without RT was 20 months, neoadjuvant RT was 24 months and adjuvant RT was 23 months (p < 0.0001) . Median survival time of 2089 stage I patients without RT was 56 months, significantly longer than those with RT regardless of neoadjuvant or adjuvant RT (no RT: 56 months vs adjuvant RT: 37 months vs neoadjuvant RT: 27 months, P=0.0039). Median survival time of 12888 stage II patients with neoadjuvant RT was 24 months, adjuvant RT 22 months, significantly prolonged than those without radiotherapy(neoadjuvant RT: 24 months vs adjuvant RT: 22 months vs no RT: 17 months, P＜0.0001). Neoadjuvant RT (HR=1.434, P=0.023, 95% CI: 1.051-1.957) was independent risk factors for prognosis of stage I patients, and adjuvant RT (HR=0.904, P < 0.001, 95% CI: 0.861-0.950) predicted better outcomes for prognosis of stage II patients by multivariate analysis. The risk of cancer-related death caused by neoadjuvant RT in stage I and no-RT in stage II patients were significantly higher. Conclusions: The study identified a significant survival advantage for the use of adjuvant RT over surgery alone or neoadjuvant RT in treating stage II pancreatic cancer. RT was not associated with survival benefit in stage I patients.
Expressions and Prognostic values of LPARs in human breast cancer
Authors: Wang Tao , Luo Zhanxiong , Chen Rixin , Li Jingzhang , Sun Kai 
Published: April 2021

Abstract
Background: LPA and its receptors play a major role in adjusting malignant behaviors in breast cancer (BC). Abnormal expression of certain LPA receptors in BC indicate that LPA receptors could be novel potential biomarkers in predicting prognosis and progression of BC. Further studies would focus on molecular mechanisms of LPA receptors in BC.Results: In this study, we examined the transcription and survival data of BC patient LPARs from ONCOMINE, Kaplan-Meier plotter, GEPIA, bcGenEx-Miner and cBioPortal database. We revealed that LPAR2/3/5 expression levels in BC tissue were higher than that in normal breast tissue, whereas the expression levels of LPAR1/4/6 in BC tissue were lower than normal breast tissue. The expression levels of LPAR1/4/6 were associated with advanced-stage tumor. Survival analysis using the K-M plotter database showed that in all BC patients, high mRNA expression of LPAR1/4/5/6 and the low mRNA expression of LPAR2/3 were correlated with the improved outcomes of BC patients. Subgroup analyses based on clinicopathological factors further revealed relationship between the expression levels of LPARs and the prognosis of BC patients with different types. Conclusions: This study shows that LPAR2/3/5 are potential targets for precision treatment of BC patients, and six LPARs are new biomarkers for the prognosis of BC patients.
Ferns and Licophytes in Coal Mining Waste and Tailing Landfills
Authors: Andreola Ariane , Rosini Daniely Neckel , Campos Mari Lucia , Biasi Josieli Pietro , Citadini-Zanette Vanilde , Bortoluzzi Roseli Lopes da Costa , Miquelutti Davi José , Nicoleite Edilane Rocha 
Published: April 2021

Abstract
Mineral coal extraction in Santa Catarina State (Brazil) Carboniferous Basin has degraded the local ecosystem, restricting the use of its areas. One of the biggest environmental impacts in the mining areas is the uncontrolled disposal of waste and sterile mining with high concentrations of pyrite, which in the presence of air and water is oxidized promoting the formation of acid mine drainage (AMD). These contaminants can be leached into water resources, restrict the use of water, soil and cause threats to fauna and flora. This study aimed to characterize these areas as to the content of Cd, Pb, Ni and Zn metals in the tailings and waste resulting from coal mining and to survey the species of ferns and lycophytes present. Wastes and tailing samples and specimens of ferns and lycophytes were collected in 23 landfills in six municipalities in the region and in four underlying areas used as controls. Chemical and physical analyses (pH in water and pH in KCl, Ca, Mg, P, K, Na, Mn, Fe, Al, clay and OM contents) were carried out and the total contents of heavy metals Cd, Pb were determined, Ni and Zn. Sampling of ferns and lycophytes was carried out by walking. The levels of heavy metals, Cd, Ni and Zn were below the prevention concentrations established by CONAMA Resolution 420/2009. Pb levels were above prevention values ​​in four landfills. Sixteen species of ferns and one lycophyte were found, with hemicryptophytes the most frequent and helophytes the most adapted to the environment. Of the species found, Pteridium esculentum (G. Forst.) Cockayne, Pityrogramma calomelanos (L.) Link and Telmatoblechnum serrulatum (Rich.) Perrie, DJ Ohlsen & Brownsey demonstrated resistance to degraded and contaminated environments with Pb, which may constitute an alternative for projects monitoring and environmental recovery.
Attribute Relationship Solving Method Based on Nodes and Communities in Opportunistic Social Networks
Authors: WU Jia , TIAN Xiaoming 
Published: April 2021

Abstract
The penetration of the 5G Internet and big data communication into human society brings about the survival basis of the social opportunistic networks. Using mobile terminal devices for communication makes the communication of nodes in the social opportunistic network intermittent, because nodes may be in motion all the time. In social opportunistic networks, data communication activities can be recorded and analyzed by evaluating communication activities of human beings or determining their interest points. However, the identification of nodes with the same or similar types of attributes among a large number of user nodes, has become a research problem in the field of social opportunistic networks. How to find an effective method to classify nodes according to their social characteristics and similarity degree becomes the key point of social opportunistic network data forwarding process. In this study, we proposed a method of community mining by decomposition of node and community relationship matrix with large social network data attributes. By using the regular type and iterative community features among community-rule-meet nodes, the method is proved to be converged and yield a minimum solution. Experimental results show that the proposed method exhibits strong application value.
Motor Torque Estimation and Security Control for Electric Vehicles (EV) Based on Parameters Feature Extraction
Authors: Zhiyuan Peng , Changhong DU , Anjian ZHOU , Li LIU , Yang CHEN , Jian CHEN , Qianlei Peng 
Published: April 2021

Abstract
Motor as well as its controller plays an important role in driving electric vehicle. As sole power device, it is closely related with actual torque accuracy to make sure security during EV driving. Due to complex controlling system for motor, there are some random failures of hardware and software which can bring a series of unexpected risks for EV acceleration or deceleration. A novel method based on motor parameters feature is proposed to estimate motor torque according to torque estimation scheme based on parameters feature extraction for three-phase of volts and currents. Additionally, Quality Factor (\(QF\)) and confidence coefficient are also adopted to judge whether motor estimation torque is reasonable or not and motor failure torque is limited to prohibit output by setting fault flag in controller software. Finally, test bench is built to estimate torque accuracy compared with actual test value and verify security control strategy at the state of failure modes, test results show that estimation torque accuracy is within ± 5Nm which is compared with actual test torque and motor system can effectively come into security state from failure state by security control strategy designed in this paper.
Determining the range of magnetic interactions from the relations between magnon eigenvalues at high-symmetry k points
Authors: Wang Di , Yu Jihai , Tang Feng , Li Yuan , Wan Xiangang 
Published: April 2021

Abstract
Magnetic exchange interactions (MEIs) define networks of coupled magnetic moments and lead to a surprisingly rich variety of their magnetic properties. Typically MEIs can be estimated by fitting experimental results. But how many MEIs need to be included in the fitting process for a material is not clear a priori, which limits the quality of results obtained by these conventional methods. In this paper, based on linear spin-wave theory but without performing matrix diagonalization, we show that for a general quadratic spin Hamiltonian, there is a simple relation between the Fourier transform of MEIs and the sum of square of magnon energies (SSME). We further show that according to the real-space distance range within which MEIs are considered relevant, one can obtain the corresponding relationships between SSME in momentum space. We also develop a theoretical tool for tabulating the rule about SSME. By directly utilizing these characteristics and the experimental magnon energies at only a few high-symmetry k points in the Brillouin zone, one can obtain strong constraints about the range of exchange path beyond which MEIs can be safely neglected. Our methodology is also general applicable for other Hamiltonian with quadratic Fermi or Boson operators.
A randomized controlled trial of an Internet-based emotion regulation intervention for sexual health: study protocol
Authors: Fischer Vinicius Jobim , Andersson Gerhard , Billieux Joël , Vögele Claus 
Published: April 2021

Abstract
Introduction: Emotion regulation difficulties have been associated with mental disorders and sexual dysfunctions. Traditional face-to-face transdiagnostic emotion regulation interventions have shown positive results for emotional and personality disorders. Only recently have the effects of these interventions on sexual health started to be investigated. Internet-delivered psychological interventions have several advantages over face-to-face interventions, such as cost-effectiveness, accessibility and suitability for people who experience shame because of their stigmatized problematic behaviors and those who avoid seeking help. The aims of the SHER 2 - TREpS (Portuguese acronym for Emotion Regulation training for sexual health) project are: a) determine the efficacy of an Internet-based emotion regulation intervention for sexual health and sexual satisfaction, and; b) explore the effects of the intervention on (1) emotion regulation skills; (2) mental health; (3) sexual self-perception. Methods and AnalysisThe study will use a randomized controlled trial design. Eligible participants will be randomly allocated to one of two groups: intervention (Internet-based emotion regulation training) or waitlist control. Assessments will take place before the start of the trial, at the end of the trial and at 6-month follow up, after which participants assigned to the waitlist control condition will receive the same intervention. Primary outcomes include sexual function and satisfaction, and secondary outcomes self-report measures of depression, anxiety, difficulties in emotion regulation, and sexual self-perception. This intervention study is financed by the Luxembourg National Research Fund (FNS). Ethics and dissemination: Ethics approval was obtained from the Ethics Review Panel of the University of Luxembourg. Findings will be disseminated via peer-reviewed publications and conference presentations.
Fine-tuning flowering time via genome editing of upstream open reading frames of Heading date 2 in rice
Authors: Li feng xiu , Liu Xinxin , Zhang Yuanye , Liu Hualong , He Mingliang , Li Rongtian , Meng Wei , Wang Zhengyu , Bu Qingyun 
Published: April 2021

Abstract
Flowering time of rice (Oryza sativa L.) is among the most important agronomic traits for region adaptation and grain yield.In the process of rice breeding, efficient and slightly modulating the flowering time of an elite cultivar would be more popular with breeder. Hence, we focus on slightly increasing the expression of flowering repressors by CRISPR/Cas9 genome editing system. It was predicated there were three uORFs in 5' leader sequence of Hd2.By editing Hd2 uORFs, we got four homozygous mutant lines and phenotypic analysis showed their heading date delay by 4.6–11.2 days relative to wide type SJ2.The mutation do not affect transcript level of Hd2, but improve translation of a downstream Hd2 pORF. In summary, we developed a efficient approach for delaying rice heading date based on editing uORF region of flowering repressor, which is time and labor saving compared to traditional breeding. In future, uORF of other flowering time related genes, including flowering promoter and flowering repressor genes, can also be used as targets to fine-tune the flowering time of varieties.
Predictive Value of Postoperative C-reactive Protein-to-Albumin Ratio in Anastomotic Leakage after Esophagectomy
Authors: Zhang Chi , Li XiaoKun , Hu LiWen , Zheng Chao , Cong ZhuangZhuang , Xu Yang , Luo Jing , Wang GaoMing , Gu WenFeng , Xie Kai , Luo Chao , Shen Yi 
Published: April 2021

Abstract
Introduction: Among the many possible postoperative complications, anastomotic leakage (AL) is the most common and serious. Therefore, the purpose of this study was to explore the ability of various inflammatory and nutritional markers to predict postoperative AL in patients after esophagectomy. Methods: A total of 273 patients were retrospectively evaluated and enrolled into this study. Perioperative, surgery-related, tumor-related and laboratory tests data were extracted and analyzed. The discriminatory ability and optimal cut-off value was evaluated according to the receiver operating characteristic (ROC) curve analysis. Univariate and multivariate analyses were performed to access the potential risk factors for AL. Results: The overall incidence of AL was 12.5% (34/273). C-reactive protein-to-albumin ratio (CAR) [AUC 0.943 (95% confidence interval (CI) = 0.911–0.976, p < 0.001)] and operation time [AUC 0.747 (95% CI = 0.679–0.815, p < 0.001)] had the greatest discrimination on AL prediction. Multivariate analysis demonstrated that CAR and operation time were two independent risk factors for AL, and CAR (OR = 87.150, p < 0.001) had an advantage over operation time (OR = 11.178, p = 0.011). Conclusion: Operation time and postoperative CAR were two independent predictive indexes for AL. Postoperative CAR greater than 3.00 indicated a high risk of AL. For patients with abnormal postoperative CAR, early non-operative treatment or surgical intervention are needed to reduce the serious sequelae of AL.
Evaluation of caregiver burden, and quality of life in metastatic prostate cancer patients and caregivers; Effects of clinical and socioeconomic factors
Authors: Yildirim Ozgen Ahmet , Poyraz Kerem , Erdur Erkan , Can Canan , Gundogan Cihan , Yerlikaya Halis , Yildirim Serdar , Guzel Yunus , Komek Halil 
Published: April 2021

Abstract
Purpose: To investigate the caregiver burden and quality of life (QoL) of patients with metastatic prostate cancer. The relationship between questionnaire results and medical, socioeconomic, disease and treatment related factors of the patients were evaluated. Methods: One hundred twenty one metastatic prostate cancer patients and caregivers were enrolled in this cross-sectional study. Short Form 36 (SF-36) questionnaires and Zarit caregiver burden interviews (ZCBI) were conducted with patients and their caregivers seperately. Patients’ comorbidities, presence of bone and visceral metastases, bone related events, palliative radiotherapy needs, ECOG scores, being under active chemotherapy, socioeconomic factors such as public transportation need, residential factors and caregiver related factors such as comorbidities and kinships were recorded respectively. Results: Patients’ comorbidities, ECOG score, presence and quantity of bone or visceral metastasis, bone related events, receiving palliative radiotherapy and chemotherapy, using public transportation resulted in lower SF-36 and higher ZCBI results (p < 0.001– p = 0.049). Obligation to live in rented houses were correlated with lower SF-36 physical function results (p = 0.043). Condition of the caregiver being from distant relatives resulted in a lower SF-36 score (p = 0.01 - p= 0.043). Moderate to strong negative correlation was detected between ZCBI and all SF-36 results (p < 0.001, r: -646 to -749). In ZCBI, score over 47 resulted with % 69.57 sensitivity and % 65.52 specificity (AUC = 0.671, p = 0.008). Conclusion: QoL was directly related to caregiver burden. Factors such as patient comorbidities, bone metastasis and related situations, ECOG score, presence of visceral metastasis, actively undergoing chemotherapy, low socioeconomic status and poor family support negatively affect both the quality of life of patients and caregiver burden. If a social assistance system can be implemented in which these factors can be monitored systematically, objective and cost-effective benefits related to the care of these patients and the maintenance of their quality of life can be achieved.
Metastructure plate with periodically embedded nonlinear vibration absorbers for nonlinear aeroelastic suppression
Authors: Tian Wei , Zhao Tian , Yang Zhichun 
Published: April 2021

Abstract
A metastructure plate featuring periodically embedded nonlinear vibration absorbers (NVAs) is proposed for the passive suppression of nonlinear aeroelastic responses under supersonic flow conditions. Using the von Karman large deformation theory and supersonic piston theory, the motion equations of a supersonic functionally graded material plate coupled with NVAs are derived from the Hamilton principle. Linear flutter analysis shows that the multiple-NVA design can significantly enhance the aerothermoelastic stability of the metastructure plate. Subsequently, the nonlinear aeroelastic behaviors of the plate and the energy transfer mechanism between it and the NVAs are examined using an energy-based analysis approach. The comparison of bifurcation diagrams indicates that the attachment of periodic NVAs realizes a superior suppression of vibration absorption than a single NVA. Numerical results show that the nonlinear dynamic responses of the plate can be substantially reduced via the targeted energy transfer of NVAs in the post-flutter regime. In particular, the passive control performance of the periodic NVAs does not degrade under an increase in the dynamic pressure. Furthermore, a significant reduction of more than 95% in the response amplitude of the plate can be realized by properly tuning the NVA parameters. The present work demonstrates that the metastructure design, based on periodically distributed NVAs, is effective at enhancing the flutter stability and mitigating nonlinear aeroelastic responses.
Climate change projections over Indus basin using CMIP6 model simulations
Authors: KUNDETI KOTESWARARAO , T.V Lakshmi Kumar , Kulkarni Ashwini , J.S Chowdary , Desamsetti Srinivas 
Published: April 2021

Abstract
Indus basin is one of the most vulnerable regions due to climate change. This article presents the projected changes in precipitation and temperature over the Indus Basin using statistically downscaled, bias-corrected Coupled Model Intercomparison Project-6 (CMIP6) data sets for different shared socioeconomic pathways (SSP2-4.5 and SSP5-8.5) in response to global warming. The future changes in precipitation and temperature extremes for different epochal periods of the 21st century are outlined. The spatial variations of precipitation, maximum and minimum temperature obtained from the Multi-Model Mean (MMM) of CMIP6 models showed a good agreement with observations such as APHRODITE (precipitation), CPC (temperature) for the base period 1995 to 2014 over the Indus Basin. Our results suggest that there is a general increase in precipitation/ maximum and minimum temperature over the Upper Indus Basin/Lower Indus Basin by the end of the 21st century. It is also noted that the spatial variability of extreme climate indices is high during June to September (JJAS) than December to January (DJF). By the end of the century projections show that the precipitation changes are about 85% in JJAS and 40% in DJF with reference to the baseline (1995–2014) period over Indus Basin region. The temperature extreme indices are also increasing in future compare to the baseline period.
Determination of the characteristic inactivation fluence for SARS-CoV-2 under UV-C radiation considering light absorption in culture media
Authors: Martínez-Anton Juan Carlos , Brun Alejandro , Vázquez Daniel , Moreno Sandra , Fernández-Balbuena Antonio A. , Alda Javier 
Published: April 2021

Abstract
The optical absorption coefficient of culture media is critical for the survival analysis of pathogens under optical irradiation. The quality of the results obtained from experiments relies on the optical analysis of the spatial distribution of fluence which also depends on the geometry of the sample. In this contribution, we consider both the geometrical shape and the culture medium’s absorptivity to evaluate how the spatial distribution of optical radiation affects pathogens/viruses. In this work, we exposed SARS-CoV-2 to UV-C radiation (λ =254 nm) and we calculated – considering the influence of the optical absorption of the culture medium – a characteristic inactivation fluence of F i =4.7 J/m2 , or an equivalent 10% survival (D90 dose) of 10.8 J/m2. Experimentally, we diluted the virus into sessile drops of Dulbecco’s Modified Eagle Medium to evaluate pathogen activity after controlled doses of UV irradiation. To validate the optical absorption mode, we carried out an additional experiment where we varied droplet size. Our model – including optical absorption and geometrical considerations – provides robust results among a variety of experimental situations, and represents our experimental conditions more accurately. These results will help to evaluate the capability of UV disinfecting strategies applied to a variety of everyday situations, including the case of micro-droplets generated by respiratory functions.