bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of Lactate, Vitamin D and Nucleated Red Blood Cells for Early Prediction of Hypoxic–Ischemic Encephalopathy: A Cross-Sectional Case-Control Study
Authors: Saad Ahmed , Thabet ahmed , Soliman Mohamed , Abdel-Aziz Alyaa 
Published: March 2021

Abstract
Objective and backgroundPerinatal asphyxia is a serious medical condition in which there is a lack of oxygen or blood flow during, or even after the labor process. So this study aimed to study serum blood levels of Lactate, vitamin D and count of Nucleated Red Blood Cells (NRBCs) per 100 White Blood Cells (WBCs) as early biological predictors of Hypoxic–Ischemic Encephalopathy (HIE) after birth Asphyxia. MethodsA cross-sectional case-control study was conducted on 20 neonates with HIE comprising the cases (APGAR ≤ 5) and another 20 neonates representing the control group with their age, sex, and weight matched, admitted to NICU from March 2020 to the end of September 2020. Venous blood samples for lactate, vitamin D and nucleated RBCs were drawn after birth and sent for analysis. Sarnat score was used to assess the severity of HIE. ResultsVenous blood levels of lactate and nucleated red blood cells per 100 white blood cells (NRBC/100 WBC) counts were significantly higher in HIE neonates than in the control group with a highly significant difference (P-value <0.001). While serum Vitamin D was significantly lower in the HIE group than in the control (P-value <0.001). ConclusionSerum lactate level, vitamin D level and NRBCs/100 WBCs might be used as biomarkers in the early prediction of HIE.
‘Preparation and characterization of a novel mucoadhesive carvedilol nano-sponge: a promising platform for buccal antihypertensive delivery’
Authors: Sallam Nahed Mohamed , Sanad Rania Abdel-Basset , Ahmed Mahgoub Mohamed , Khafagy EL Sayed Abdu , Ghorab Mamdouh Mostafa , Gad Shadeed 
Published: March 2021

Abstract
Purpose: Carvedilol (CRV) is a non-selective beta-blocker used for hypertension treatment, angina pectoris, and heart failure. Oral administration of CRV showed poor bioavailability (25%), which may be due to exposure to the first-pass metabolism. Buccal delivery was used to boost its bioavailability.Methods: In this study carboxymethylcellulose/hydroxypropyl cellulose (CMC/HPC) composite buccal sponge enriched with CRV bilosomes was developed. Bilosomes were prepared using the thin-film hydration-sonication technique by applying a 32 -factorial design.Results: BL9 possessed the highest desirability value (0.861) and therefore, it was chosen as an optimal bilosomes. It exhibited a spherical shape with 217.2 nm, 87.13% entrapment efficiency, and a sustained release of CRV up to 24h. Consecutively, BL9 was incorporated in a CMC/HPC gel and lyophilized for 24 h to obtain a CMC-HPCL9 bilosomal sponge to enhance CRV buccal delivery. Morphological analysis of the prepared sponge with improved swelling showed a porosity of 67.58 percent. The in vivo assessment of rats indicates that the CMC-HPC/BL9 sponge enhances systolic/diastolic blood pressure, lipid profiles, oxidative stress biomarkers, and heart biomarkers with improved heart tissue quality.Conclusion: These results strongly encourage the use of this novel CMC-HPC/BL9 composite buccal sponge for the management of hypertension.
Modified Laparoscopic Lateral Suspension with A 5 Arm Mesh in Pelvic Organ Prolapse Surgery.
Authors: Akbaba Eren 
Published: March 2021

Abstract
Background: The LLS procedure is a laparoscopic technique used to treat pelvic organ prolapse (POP), performed with a T-shaped synthetic mesh graft. The posterior compartment is repaired by using a second mesh or a second procedure like posterior colporrhaphy in the LLS procedure. In laparoscopic lateral suspension (LLS) surgery, we want to repair the defect of the posterior compartment in addition to the apical and anterior compartment by using a 5-arm mesh instead of a T-shaped synthetic mesh graft. In this study, we aim to report clinical results of surgeries performed POP repair with a 5-arm mesh.Method: Data from 37 patients who underwent LLS surgery by using a 5-arm mesh with a diagnosis of advanced stage (≥ stage 3) POP and the defect of the posterior compartment were retrospectively analyzed. The postoperative examination included grading and measurement of the POP-Q stage. Surgical outcomes were reported in pursuance of the International Urogynecological Association recommendations. The results of measurements and examinations, the reoperation rates, the erosion rates, lower urinary tract symptoms (LUTS), and complications were recorded. A p-value of < 0.05 was considered to be statistically significant.Results: There was a significant improvement in POP-Q ≤ −1 score in all treated compartments with an overall objective cure rate of 95.3% for the apical compartment, 86.1% for the anterior compartment, and 91.1% for the posterior compartment. The mean operative time was 96.27±15.81 minutes. The mean length of hospitalization was 2±0.82 days. A significant improvement was observed in symptoms of the vaginal bulge, urinary urgency, incomplete voiding, urinary frequency after surgery. Also, an improvement occurred in defecation symptoms of patients after POP repair. While 13 of the patients (35.1%) were sexually active preoperatively, this rate was determined to be 59.4% (n=22) postoperatively. De novo stress urinary incontinence developed in 7 patients (18.9%) postoperatively. The POP-related quality-of-life score (PQOL) improved significantly after surgery.Conclusion: İn advanced stage POP patients undergoing laparoscopic lateral suspension procedure using a 5-arm mesh, damaged compartments including the posterior compartment can be repaired without the need for an additional procedure and the recurrence rate can be reduced.
Enhanced Photocatalytic Performance of Nb Doped TiO2/reduced Graphene Oxide Nanocomposites Over Rhodamine B Dye Under Visible Light Illumination
Authors: Prabhakarrao N. , Lakshmi K.V. Divya , Divya G. , Jaishree G. , Raju Imandi Manga , Alim Shaik Abdul , Tirukkovalluri Siva Rao 
Published: March 2021

Abstract
The present study discusses the synthesis of Nb doped TiO2/reduced Graphene Oxide (GO) intercalated nanocomposites via sol-gel route at a lower temperature by using different loading amounts of GO (1 to 10 wt%). The synthesized composite materials were further characterized by copious instruments such as X-ray Diffractometer, UV-vis Diffuse Reflectance Spectroscopy, Scanning Electron Microscopy, Transmission Electron Microscopy, BET surface area analysis, Raman and FT-Infrared Spectroscopy. The experimental results stated that the Nb doped TiO2 nanoparticles uniformly distributed on the surface of reduced Graphene Oxide (rGO) with an interfacial linking bond between TiO2 and rGO. Later, the photocatalytic degradation of Rhodamine B dye using produced materials under visible light irradiations was examined. These results reveal that Nb doped TiO2/rGO nanocomposites exhibited better photocatalytic performance than Nb doped TiO2 for the removal of Rhodamine B dye. However, among all, the nanocomposite having 5% of GO content achieves the highest degradation rate for Rhodamine B dye approximately 98% under visible light exposure. Overall, the unique properties such as electron accepting and transporting properties of GO in the nanocomposites help to enhance photocatalytic activity by minimizing the charge carrier’s recombination rate.
Vermicompost Assisted Phytoremediation of Heavy Metal Contaminated Soil in Madaka District, Nigeria Using Melissa officinalis L (Lemon balm) and Sida acuta (Stubborn weed)
Authors: aransiola sesan abiodun , Ijah Udeme Joshua Joshia , Abioye Olabisi Peter , Bala Jeremiah David 
Published: March 2021

Abstract
This research was designed to clean-up through an environmentally friendly techniques, a polluted environment of Madaka District of Shikira. Physicochemical properties of the soil were done using standard methods. Chicken dropping vermicompost (CDV) and goat manure vermicompost (GMV) were produced by standard method to assist the phytoremediation process with plant growth promoting bacteria (PGPB). Canonical discriminant functions of the heavy metals were done. For the first location (AK) the plant parts of M. officinalis L mopped up heavy metals, the concentration of Cd, As, Pb in plant parts varied from 0.007 to 0.33 mg/kg, As from 0.09 to 4.39 mg/ kg and Pb from 0.07 to 10.35 mg/kg respectively while the concentration of heavy metals in S. acuta parts had Cd, As, Pb varied from 0.002 to 0.43 mg/kg, As from 0.27 to 3.79 mg/ kg and Pb from 1.68 to 10.7 mg/kg respectively. The second location (AM) also had the two plants mopping up heavy metals at different concentrations. the concentration of Cd, As, Pb in M. officinalis L parts varied from 0.03 to 0.41 mg/kg, As from 0.65 to 4.65 mg/ kg and Pb from 1.93 to 11.49 mg/kg respectively while the concentration of heavy metals in S. acuta parts had Cd, As, Pb varied from 0.06 to 0.66 mg/kg, As from 0.68 to 4.64 mg/ kg and Pb from 1.53 to 11.53 mg/kg respectively. Melissa offinalis L and Sida acuta were found most suitable for phytoextraction of sites contaminated with Cd, As and Pb because both of them have their bioconcentration factor (BCF), translocation factor (TF) and biological accumulation coefficient (BAC) to be ˃1 while both were also scored as phytostabilizer because they have BCF ˃1 and TF ˂1. Soil structural changes pre and post remediation were determined through x-ray fluorescence (XRF spectroscopy) and scanning electron microscopy (SEM) analyses.
Relación Mapuche y Naturaleza: Fundamentos Epistémicos para una Educación Ambiental en Contextos Interculturales
Authors: Beltrán-Veliz Juan Carlos , Tereucán Angulo Julio Cesar , Pérez Morales Sergio Hernán , Klenner Loebel Maura Paulina 
Published: March 2021

La escuela en contextos mapuche, funciona sistemáticamente para reproducir y perpetuar la cultura occidental eurocéntrica, provocando que persista una visión reduccionista, fragmentada y deshumanizante del estudiante sobre la forma de comprender la realidad. En efecto, quedan excluidas las formas de pensar, conocer y comprender la relación entre el mapuche y la naturaleza. Se propuso el objetivo: Develar descriptivamente los fundamentos epistémicos que subyacen a la relación entre el mapuche y la naturaleza. Este estudio, se enmarcó en el paradigma interpretativo, situado en el enfoque metodológico cualitativo, de alcance descriptivo denso, en base a la teoría fundamentada constructivista. Las técnicas que se emplearon para recolectar los datos, fueron la entrevista en profundidad y grupo focal. Los principales resultados develan que el az-mapu, es un código ético y moral, pues regula el actuar y vivir del mapuche en vinculación con la naturaleza. Se observa el principio de reciprocidad, entendido como la correspondencia mutua entre la naturaleza y el mapuche, sustentada en el respeto, solidaridad, empatía, cuidado y amor. Asociado a lo anterior, se aprecia el küme mogen el cual representa el modo de vida del mapuche, el que se da bajo una relación equilibrada, desde la forma de pensar y actuar sobre la base del respeto entre mapuche y la otredad y, especialmente con la naturaleza, desde una perspectiva espiritual y material. Se concluye que los fundamentos epistémicos: az-mapu, reciprocidad y küme mogen, constituyen un aporte sólido para la educación ambiental, en contextos educativos interculturales, dado que promueven el desarrollo armónico de la persona en el aspecto físico, cognitivo, actitudinal, afectivo, espiritual y material, con la finalidad de que mantenga un comportamiento adecuado hacia la naturaleza. Esto contribuiría a mitigar los problemas que son parte de la crisis ambiental.
Synthesis of Some Novel Benzimidazole Derivatives as Anticancer Agent
and Evaluation for CDK2 Inhibition Activity
Authors: El-Hameed Rania Helmy Abd , Fatahala Samar Said , Sayed Amira Ibrahim 
Published: March 2021

Background:
Thiobezimidazoles reveal various pharmacological activities due to similarities with many natural and synthetic molecules, they can easily interact with biomolecules of living systems.

Objective:
A series of substituted 2-thiobezimidazoles has been synthesized .Twelve final compounds were screened for in vitro anti-cancer activities against sixty different cell-lines.

Methods:
The spectral data of the synthesized compounds were characterized. Docking study for active anticancer compounds and CDK2/CyclinA2 Kinase assay against standard reference; Imatinib were performed.

Results:
Two compounds (3c&3l) from the examined series revealed effective antitumor activity in vitro against two-cancer cell lines (Colon Cancer (HCT-116) and Renal Cancer (TK-10). The docking study of synthesized molecules discovered a requisite binding pose in CDK-ATP binding pocket. 3c &3l were promoted in the CDK2/CyclinA2 Kinase assay against standard reference Imatinib.

Conclusion:
Against all tested compounds ; two compounds 3c &3l were found active against two types of cell-lines.
Community and Campus COVID-19 Risk Uncertainty Under University Reopening Scenarios: Model-Based Analysis
Authors: Benneyan James , Gehrke Christopher , Ilies Iulian , Nehls Nicole 
Published: March 2021

BackgroundSignificant uncertainty has existed about the safety of reopening college and university campuses before the COVID-19 pandemic is better controlled. Moreover, little is known about the effects that on-campus students may have on local higher-risk communities.ObjectiveWe aimed to estimate the range of potential community and campus COVID-19 exposures, infections, and mortality under various university reopening plans and uncertainties.MethodsWe developed campus-only, community-only, and campus × community epidemic differential equations and agent-based models, with inputs estimated via published and grey literature, expert opinion, and parameter search algorithms. Campus opening plans (spanning fully open, hybrid, and fully virtual approaches) were identified from websites and publications. Additional student and community exposures, infections, and mortality over 16-week semesters were estimated under each scenario, with 10% trimmed medians, standard deviations, and probability intervals computed to omit extreme outliers. Sensitivity analyses were conducted to inform potential effective interventions.ResultsPredicted 16-week campus and additional community exposures, infections, and mortality for the base case with no precautions (or negligible compliance) varied significantly from their medians (4- to 10-fold). Over 5% of on-campus students were infected after a mean of 76 (SD 17) days, with the greatest increase (first inflection point) occurring on average on day 84 (SD 10.2 days) of the semester and with total additional community exposures, infections, and mortality ranging from 1-187, 13-820, and 1-21 per 10,000 residents, respectively. Reopening precautions reduced infections by 24%-26% and mortality by 36%-50% in both populations. Beyond campus and community reproductive numbers, sensitivity analysis indicated no dominant factors that interventions could primarily target to reduce the magnitude and variability in outcomes, suggesting the importance of comprehensive public health measures and surveillance.ConclusionsCommunity and campus COVID-19 exposures, infections, and mortality resulting from reopening campuses are highly unpredictable regardless of precautions. Public health implications include the need for effective surveillance and flexible campus operations.
ARTISTS FROM BUNDELKHAND: COLOR COMBINATION OF KISHAN SONI'S PAINTINGS
Authors: Pathak Garima 
Published: March 2021

The art seeker of Bundelkhand, Mr. Kishan Soni ji was born in U.P. It was held in Jhansi district of 19 November 1958. His father Mr. Suraj Prakash Soni was originally Rajasthani but has been living in Jhansi for many years, his mother's name is Mrs. Chanda Soni. In 1975, Soni ji passed the high school examination but under the circumstances he could not study further. Today, by looking at his personality, behavior and knowledge, no one can think that there are few stages of his institutional education left and he is also a true example of the fact that 'art is not an attachment to any schooling and knowledge'Since childhood, Soni ji saw her father embellishing the clothes, so in him, according to the genetic properties, the qualities of an artist automatically came into being. His mother always kept his morale high. Soni ji, in his childhood, learned his father's work of embroidery and started helping him for Dharnjan, but he did not mind in this work. Then he, with the inspiration of his mother, shifted his attention to painting. He made his first person portrait of his 'granny mother'. At this time, he was only 14 years of age.
बुन्देलखण्ड के कला साधक श्री किशन सोनी जी का जन्म उ.प्र. के झांसी जिले में 19 नवम्बर सन् 1958 को हुआ। इनके पिता जी श्री सूरज प्रकाश सोनी मूलतः राजस्थानी थे लेकिन कई वर्षों से झांसी में ही रह रहे हैं इनकी माताजी का नाम श्रीमति चंदा सोनी है। सन् 1975 में सोनी जी ने हाई स्कूल की परीक्षा पास की लेकिन परिस्थितिवश वे आगे नहीं पढ़ सके। आज उनके व्यक्तित्व, व्यवहार और ज्ञान को देखकर कोई भी यह नहीं सोच सकता कि उनकी संस्थागत शिक्षा के कुछ चरण बाकी रह गये है और वह इस तथ्य के भी साक्षात् उदाहरण है कि ‘कला किसी भी स्कूली शिक्षा व ज्ञान की मोहताज नहीं’बचपन से ही सोनी जी ने अपने पिता जी को वस्त्रों को अलंकृत करते हुए देखा अतः उनके अन्दर आनुवांशिकी गुणो के अनुसार एक कलाकार के गुण स्वतः ही आ गए । इनकी माता जी ने इनका मनोबल हमेशा बढ़ाए रखा। सोनी जी ने बालपन में ही अपने पिता जी ने कढाई का काम सीख लिया और धर्नाजन हेतु उनकी सहायता करने लगे परन्तु इस काम में इनका मन नहीं लगा। तब इन्होने अपनी माता जी की प्रेरणा से, चित्रकला की ओर अपना ध्यान केन्द्रित किया। इन्होने अपना प्रथम व्यक्ति चित्र अपनी ‘नानी मां’ का बनाया। इस समय इनकी आयु महज 14 वर्ष की थीं।
Recent Echocardiography Parameters for Predicting Better Functional Result after Mitral Valve Correction Surgery in Patients with Primary Mitral Regurgitation
Authors: Puspita Indah , Soesanto Amiliana M , Rudiktyo Estu , Ariani Rina , Kuncoro Ario Suryo 
Published: March 2021

Abstract

Objectives We analyzed whether some echocardiographic parameters are good predictors of functional result after mitral valve correction surgery.

Background Ejection fraction was not the only parameter to decide optimal time for surgery, nor an indicator for a better functional result after surgery. Severity measurement being a main consideration in surgery decision. Reduced left ventricle dimension after surgery reflect a better functional result.

Methods In 2019, 67 patients was included in this analysis. Age 53 (17-67) years, male 52,2%. All patients are with severe primary mitral regurgitation and treated by mitral valve surgery (mitral valve repair or replacement). Retrospective echocardiographic analysis was performed, to find the best parameter for predicting better functional outcome after surgery.

Results Data was collected from January to December 2019. From 262 primary mitral valve surgery underwent in National Heart Center Harapan Kita, there was 67 patients included, the other was excluded due to probability of secondary mitral regurgitation mechanism, concomitant congenital heart disease and or other significant valves disease, missing post-surgery data due to referral flow to the prior hospital and less complete echocardiographic views for further analysis. In bivariate analysis, end-diastolic volume (EDV) and regurgitant volume (RV) were strong predictor of decreasing left ventricle diameter after surgery (p 0.0001 and p 0.05). End-diastolic volume 133,5 ml or more is predictive for decreasing left ventricle diameter if surgery was conducted (sensitivity 87.3%, sensitivity 66.7%).

Conclusions EDV and RV found to be good predictors for functional outcome of primary mitral valve surgery than other echocardiographic parameters. Measuring EDV before deciding timing of surgery will be helpful in targeting better functional result after surgery.
Relationships Between Cognition and Neuropathological Tau in Alzheimer’s Disease Assessed by 18F Flortaucipir PET
Authors: Devous Sr. Michael D. , Fleisher Adam S. , Pontecorvo Michael J. , Lu Ming , Siderowf Andrew , Navitsky Michael , Kennedy Ian , Southekal Sudeepti , Harris Thomas S. , Mintun Mark A. 
Published: March 2021

Background: Tau neurofibrillary tangle burden increases with Alzheimer’s disease (AD) stage and correlates with degree of cognitive impairment. Tau PET imaging could facilitate understanding the relationship between tau pathology and cognitive impairment. Objective: Evaluate the relationship between 18F flortaucipir uptake patterns and cognition across multiple cognitive domains. Methods: We acquired flortaucipir PET scans in 84 amyloid-positive control, mild cognitive impairment (MCI), and AD subjects. Flortaucipir standardized uptake value ratio (SUVr) values were obtained from a neocortical volume of interest (VOI), a precuneus VOI, and VOIs defined by the correlation between flortaucipir SUVr images and domain-specific cognitive tests. Cognitive assessments included Mini-Mental State Exam (MMSE), Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-cog), and a neuropsychological test battery (i.e., Wechsler Memory Scale-Revised Logical Memory (WMS-R), Trail Making Test, Boston Naming Test, Digit Symbol Substitution Test, Animal List Generation, WMS-R Digit Span, American National Adult Reading Test, Clock Drawing Test, Judgment of Line Orientation, and WMS-R Logical Memory II (Delayed Recall)) and the Functional Activities Questionnaire (FAQ). Correlation analyses compared regional and voxel-wise VOIs to cognitive scores. Results: Subjects included 5 controls, 47 MCI, and 32 AD subjects. Significant correlations were seen between both flortaucipir and florbetapir SUVrs and MMSE, ADAS-Cog, and FAQ. Cognitive impairment was associated with increased flortaucipir uptake in regionally specific patterns consistent with the neuroanatomy underlying specific cognitive tests. Conclusion: Flortaucipir SUVr values demonstrated significant inverse correlations with cognitive scores in domain-specific patterns. Findings support the hypothesis that PET imaging of neuropathologic tau deposits may reflect underlying neurodegeneration in AD.
Effect of Product Quality and Service Quality on Customer Loyalty with Customer Satisfaction as an Intervenning Variables (Case Study on the Tirta Jasa Lampung Selatan Regional Company (PDAM))
Authors: Hakim Lukman Nuzul 
Published: March 2021

This study aims to determine the effect of Product Quality and Service Quality on Customer Satisfaction and Loyalty at the Tirta Jasa Regional Drinking Water Company (PDAM), Lampung Selatanar. The sample used is 220 (10 times the number of research indicators there are 22), the data analysis used is path analysis SEM (Structural Equation Modeling) model processed with the Amos version 22 program.The results of this study found that:

Directly, product quality has a positive and significant effect on customer satisfaction and also on customer loyalty.
Directly, service quality has a positive and significant effect on customer satisfaction and also on customer loyalty.
Directly and indirectly, product quality has a positive and significant effect on customer loyalty.
Directly and indirectly service quality has a positive and significant effect on customer loyalty.
Customer satisfaction has a positive and significant direct effect on customer loyalty.