bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic informative value of liquid-based cytology optimized with genetic methods for the differential diagnosis of precancerous and malignant diseases of the cervix
Authors: Kit O. I. , Maksimov A. Yu. , Timoshkova M. Yu. , Lukbanova E. A. , Petrusenko N. A. , Potemkin D. S. , Verenikina E. V. , Shevchenko A. N. , Kecheryukova M. M. 
Published: June 2021

Purpose of the study. Was to assess diagnostic informative value of liquid-based cytology optimized with genetic methods for the differential diagnosis of precancerous and malignant diseases of the cervix.Materials and methods. The study included 381 patients. Cervical pathologies were diagnosed with liquid-based cytology only and liquid-based cytology optimized with genetic methods of assessing the expression of miRNA‑20a, miRNA‑375, miRNA‑21 and –23b. Results of liquid-based cytology and genetic methods were verified by histological examination of the material. Statistical analysis was performed using descriptive statistics methods with the calculation of the mean and standard error of the mean. The mean values were compared with the help of the Mann-Whitney test.Results. Diagnostic results of liquid-based cytology were consistent with histological results in 107 (73.8 %) of 145 cervical cancer (CC) patients, in 52 (57.1 %) of 91 patients with high-grade squamous intraepithelial lesions (HSIL), and in 30 (65.2 %) of 46 patients with low-grade squamous intraepithelial lesions (LSIL). Optimization of liquid-based cytology by assessing the expression of miRNA‑21 and miRNA‑23b in the cervical epithelium improved the diagnostic sensitivity of the method from 73.8 % to 80 %, and its specificity from 94.1 % to 97.9 %. The diagnostic sensitivity and specificity of liquid-based cytology for differential diagnosis of CC and HSIL was 87 % and 78.8 %, respectively. Optimization of liquidbased cytology by assessing the expression of miRNA‑20a and miRNA‑375 in the cervical epithelium for the differential diagnosis of CC and HSIL improved the diagnostic sensitivity of the method from 87 % to 95.1 %, and its specificity from 78.8 % to 93.9 %.Conclusions. We revealed the most informative pairs of miRNAs in the cervical epithelium, as an analysis of their expression expanded the possibilities of liquid-based cytology both as a method for diagnosing CC and as a method for the differential diagnosis between CC and HSIL.
Bladder cancer. A retrospective analysis of the use of vinfluvin in real clinical practice
Authors: Zhabina A. S. , Novikov A. I. , Moiseenko F. V. , Volkov N. M. , Stepanova E. O. , Artemeva E. V. , Abduloeva N. H. , Moiseenko V. M. 
Published: June 2021

Purpose of the study. There is the generalized analysis of administration of vinflunine in real clinical practice in St.Petersburg Clinical Scientific and Practical Center of Specialized medical Care (oncological).Materials and methods. This analysis gathered 27 patients with urothelial carcinoma treated using this medicine in St.Petersburg Clinical Scientific and Practical Center of Specialized medical Care (oncological). We assessed efficacy, safety profile of vinflunine in this subset of patients.Results. Clinical efficacy of vinflunine (complete response + partial response + stable disease) was 51,86 %, one patient demonstrated complete response. Median of response duration accounts for 3,4 months. Adverse events were observed in 28,4 %, most of them were 1-2 grades. 2 patients stopped therapy due to adverse events.Conclusion. In our analysis vinflunine was more effective than in randomized clinical trial and other studies from real practice in Europe. Thus, confirm expediency to administer of vinflunine for metastatic urothelial carcinoma.
A clinical trial of the efficacy of a combination of antiseptic and antimicrobial agent in the treatment of inflammatory processes of the skin and soft tissue
Authors: Grigoryan A. Yu. , Bezhin A. I. , Sukovatykh B. S. , Blinkov Yu. Yu. 
Published: June 2021

Purpose of the study. To conduct a clinical trial of the local treatment efficacy of skin and soft tissue inflammatory processes combination with sodium carboxymethylcellulose, immobilized miramistin and metronidazole.Patients and methods. The study involved patients with purulent-inflammatory skin processes, divided into two groups – control and experimental – 30 in each. The most common nosological form were abscesses of various localization. In the control group, local treatment was carried out with dioxomethyltetrahydropyrimidine ointment with chloramphenicol, and in the experimental group – with a combination of sodium carboxymethylcellulose with miramistin and metronidazole. We studied the local temperature, wound pH, wound planimetry, the appearance of wounds, the species composition of infectious agents in the discharge from the wound, a general blood test (with the determination of leukocyte indices), blood biochemical parameters, and the number of bed-days in the hospital. The data obtained were processed statistically.Results. The percentage of reduction in the area and volume of wounds in the experimental group was significantly higher than in the control. The maximum rate of wound healing in the experimental group was noted on days 1-3 and amounted to 9.7 (6.3; 15.5) % / day, and in the control group – 5.6 (2.9; 7.7). Starting from the 5th day of treatment, the local temperature indices in the experimental group were significantly lower than in the control group, and the pH values of the wounds in the experimental group tended to neutral values from the 5th day of treatment, and in the control group there was an increase in pH. Most often, S. epidermidis and S. aureus were inoculated from the wound discharge (in total, more than 50 % of observations); in the control group, pathogenic microorganisms were inoculated 1.6 times more often than in the experimental group.Conclusion. Patients in the experimental group were hospitalized for 2.5 days less than patients in the control group. It is possible to recommend further study and application of the combination of miramistin and metronidazole immobilized on the sodium salt of carboxymethylcellulose in the treatment of wounds.
Predictive value of MMP-2, MMP-9, TIMP-1 in surgical treatment of localized renal cell cancer
Authors: Tarasenko A. I. , Rossolovskiy A. N. , Berezinets O. L. , Durnov D. A. , Popyhova E. B. , Popkov V. M. 
Published: June 2021

Purpose of the study.To determine the association of individual biomolecular markers of oncogenesis MMP‑2, MMP‑9 and the inhibitor of metalloproteinases TIMP‑1 with the risk of tumor invasion and metastasis in the early and late postoperative period in various types of surgical treatment of RCC.Materials and methods.The study prospectively included medical data of 60 patients with kidney cancer with T1-3N0 M0 who received surgical treatment at the Urology Clinic of the S.R.Mirotvortsev Design Bureau of the SSMU from 2016 to 2019. The patients were divided into 3 groups: 1st group included 20 patients who underwent kidney resection for elective indications, with tumors of the renal parenchyma; 2nd group – 20 patients who underwent radical nephrectomy by laparoscopic approach; Group 3-20 patients who underwent radical nephrectomy with lumbotomy access. All patients being in the early (7-10th day) and long-term postoperative period (after 1 and 2 years) by solid-phase ELISA, on a StatFax 4200 analyzer using eBiosence and Cloud-Clone Corp reagent kits, a study was made on the basis of the concentration in the blood serum of markers of oncogenesis MMP‑2, MMP‑9 and TIMP‑1 metalloproteinase inhibitor.Results.In all groups of patients with RCC, an initial increase in the concentration of MMP‑9 was revealed compared to the control (p≤0.05). According to the results of the ROC analysis, this indicator has a high specificity and sensitivity in terms of predicting RCC at the preoperative stage. The highest sensitivity and specificity for detecting tumor progression was demonstrated by matrix metalloproteinases: MMP‑2 – sensitivity 96 %, specificity 67 % (cut-off point 357.5 pg/ml) and MMP‑9 – sensitivity 87.5 % and specificity 62 % (cut-off point 958 ng/ml). At the same time, TIMP‑1 showed less significant indicators – sensitivity and specificity (74 % and 60 %, respectively) with a cut-off point of 0.49 ng/ml.Conclusion.Serum MMP‑2 and MMP‑9 are a marker of a poor prognosis for the progression of RCC. Elevated levels of MMP‑9 in the blood serum of RCC patients before and after various types of surgical treatment reflect the individual characteristics of the patient’s body and the tumor process. Dynamic monitoring of the level of markers of oncogenesis in patients with RCC allows a personalized approach to the choice of the scope and method of surgical treatment of RCC.
Cystatin C as a predictor of acute renal damage after radical surgical treatment in patients with muscle-invasive bladder cancer
Authors: Tarasenko A. I. , Pavlov V. N. , Kabirov I. R. , Alekseev A. V. , Urmantsev M. F. 
Published: June 2021

Purpose of the study. To assess the clinical and prognostic significance of serum and urinary cystatin C (uCys-C and sCys-C) in patients undergoing radical cystectomy (RC) in relation to AKI.Patients and methods. In this prospective study, uCys-C and sCys-C levels were measured during the first week after undergoing RC in a heterogeneous group of patients undergoing RC (n=186), mean age 59.5±11.4 years. The observation period of the patients was 6 months. The diagnosis of AKI that developed within the first week after surgery was based on the KDIGO criteria.Results. Of the 186 examined patients, 43 developed AKI according to generally accepted criteria. During the follow-up period, no patient required renal replacement therapy. AKI patients had a longer hospital stay (22.4±22.9 versus 13.0±4.1). The sCys-C levels were significantly associated with the occurrence of AKI and CKD in the long-term postoperative period and had an area under the ROC curve of 0.76 and 0.81, respectively, for predicting severe outcomes. At an optimal cut-off value of 161.17 ng/ml, sCys-C showed a sensitivity of 65 % and a specificity of 58 % for predicting AKI. The greatest increase in the concentration of sCys-C was detected 6-12 hours after surgery, followed by a decrease in the long-term follow-up.Conclusion. Peak sCys-C levels are associated with AKI and independently predict the development of AKI in patients after RC and the onset of CKD within 6 months.
Primary hydatid cyst of the psoas adherent to the aortoiliac axis: a real therapeutic challenge
Authors: Rahali Anwar , Mssrouri Rahal , Baiss Marouane , Mansouri Abderrahmane , Mohamed Hamid , Mdaghri Jalil , Lahlou Khalid , Benamr Said , Settaf Abdellatif 
Published: June 2021

<p class="abstract">Hydatidosis of the psoas is an unusual entity even in countries endemic to hydatid disease. We reported a rare case of hydatid cyst of psoas in a 54 year old man without pathological history. The atypical clinical presentation and the uncharacterizable radiology have demonstrated the essential role of surgery and histological analysis in the management of this type of lesion. The patient underwent a resection of the protruding dome with drainage of the residual cavity because of the anatomical relationships of this hydatid cyst. Through this case and literature review, we aimed to discuss the diagnostic means, the natural course of the disease, the differential diagnoses as well as the therapeutic options for a hydatid cyst of the psoas.</p>
Improvement of Language Understanding using Sentence Identification Methods in Mathematics Subject of Story Matter in 4th Grade MI
Authors: Minarni Lilik 
Published: June 2021

This aims of study is to improve the understanding of language by identifying the main sentence in mathematics subject especially in the story matter. The methods of this research is class room action reseach by doing two cycles proccess. The collecting data method was obtained by observation, test, and documentation. Data analysis proccess was done by using an interactive model consisting of four components of analysis including data colection, selection, presentation, and conclusion.Based on the results, sentences identification learning method can be increased language understanding to solve the problem of story matter in mathematic subject in 4th grade in MI. Thus, it could be concluded that in mathematics learning by using sentences identification methods can be used to increase MI student ability to solve the story of matter. By the methods, the students will be easy to understand the sentences, so thet can finish and solve the test, and also they can made their sentences on their mind.
Classification of the Children with ADHD and Healthy Children Based on the Directed Phase Transfer Entropy of EEG Signals
Authors: Ekhlasi Ali , Motie Nasrabadi Ali , Mohammadi Mohammadreza 
Published: June 2021

Purpose: The present study was conducted to investigate and classify two groups of healthy children and children with Attention Deficit Hyperactivity Disorder (ADHD) by Effective Connectivity (EC) measure. Since early detection of ADHD can make the treatment process more effective, it is important to diagnose it using new methods.
Materials and Methods: For this purpose, Effective Connectivity Matrices (ECMs) were constructed based on Electroencephalography (EEG) signals of 61 children with ADHD and 60 healthy children of the same age. ECMs of each individual were obtained by the directed Phase Transfer Entropy (dPTE) between each pair of electrodes. ECMs were calculated in five frequency bands including, delta, theta, alpha, beta, and gamma. Based on ECM, an Effective Connectivity Vector (ECV) was constructed as a feature vector for the classification process. Furthermore, ECV of different frequency bands was pooled in one global ECV (gECV). Multilayer Artificial Neural Network (ANN) was used in the steps of classification and feature selection by the Genetic Algorithm (GA).
Results: The highest classification accuracy with the selected features of ECV was related to theta frequency band with 89.7%. After that, the delta frequency band had the highest accuracy with 89.2%. The results of ANN classification and GA on the gECV reported 89.1% of accuracy.
Conclusion: Our findings show that the dPTE measure, which determines effective connectivity between the brain regions, can be used to classify between ADHD and healthy groups. The results of the classification have improved compared to some studies that used the functional connectivity measures.
INTERPRETING RUH AS AN ECOLOGICAL SPIRITUALITY IN RELATION TO ISLAM AND JAVA MYSTICISM
Authors: Ubaidillah Ubaidillah 
Published: June 2021

This research aims to explain about the acculturation of Islam and Javanese wisdom in interpreting ruh (spirit) as an ecological behavior in dealing with natural disaster and exploitative activities. The concept of spirit refers to the awareness to interpret the relationship between human and nature as a living macrocosm unit. The awareness, in Islam, is a dimension of Sufi that blends with nature, such as Javanese philosophy on the principle of the unity of nature. It employs descriptive analytical method by integrating theo-sufistic paradigm to find a turning point in the common ground between Islam and Java in preserving the nature. The analysis goes into three conclusions: 1) the concept of spirit in Islam is a representation of one’s love with nature as the manifestation of love with God in its essence; 2) Javanese beliefs and rituals in ruh as a living and valuable existence signified in mystical mythology for being haunted and sacred serves as theo-sufistic expressions of Islam and Java; 3) spirituality of the spirit generates awareness of the philosophy of Sangkan Paraning Dumadi, to live in harmony and balance between humans and nature. Penelitian ini ingin menjelaskan tentang akulturasi Islam dan kearifan Jawa dalam memaknai ruh sebagai perilaku ekologis dalam menangani kerusakan alam dan aktivitas eksploitatif. Konsep ruh yang dimaksud adalah kesadaran memaknai hubungan manusia dan alam sebagai satu kesatuan makrokosmos yang hidup. Kesadaran tersebut dalam Islam merupakan dimensi sufistik yang menyatu dengan alam sebagaimana falsafah Jawa tentang prinsip kesatuan alam. Penelitian ini menggunakan metode deskriptif analitis dengan pendekatan integratif dalam paradigma teo-sufistik untuk menemukan titik balik persamaan persepsi antara Islam dan Jawa dalam memelihara alam hayati. Hasilnya, pertama, konsep ruh dalam Islam adalah representasi dari mencintai alam sebagai manfestasi mencintai Tuhan dengan dzatnya. Kedua, keyakinan dan ritual yang dilakukan masyarakat Jawa atas ruh sebagai eksistensi yang hidup dan memberi manfaat yang mewujud dalam mitologis mistik yang disebut angker dan sakral sebagai ekspresi teo-sufistik Islam dan Jawa. Ketiga, spiritualitas ruh memberikan kesadaran dalam filosofi Jawa tentang Sangkan Paraning Dumadi sebagai makna hidup untuk dapat serasi dan seimbang antara manusia dan alam.
SYMBOLIC MEANING OF KESANDINGAN RITUAL IN PROBOLINGGO
Authors: Nurhadi Nurhadi , Faisol Faisol , Ibrahim Faisal Mahmoud Adam 
Published: June 2021

Kesandingan, one of the rituals in Probolinggo, East Java, is a cultural phenomenon that mingles with religious elements of society. It is something sacred and mystical that parents do when a toddler (an infant under three years old) experiences heat illness for days, tends to be fussy, cries a lot, and cannot sleep at night. This research aims to explain the process of symbolic communication of kesandingan ritual and to understand the symbolic meaning behind the ritual. It is a descriptive-qualitative study through observation, in-depth interviews, and documentation. The data analysis uses a qualitative-naturalistic technique. The result demonstrates that the symbolic communication process of kesandingan ritual in Mentor, Sumberasih, Probolinggo, comprises seven series: burning incense, wiping incense smoke on the child's face, giving the child holy water to drink, wiping the child with floral water, preparing food, making a wish on the child's bed, and distributing food. Meanwhile, the symbolic meaning of kesandingan ritual refers to divine, social and personal dimensions. Ritual kesandingan merupakan salah satu ritual masyarakat Probolinggo Jawa Timur yang sudah menjadi fenomena budaya yang berbaur dengan unsur religi masyarakat. Ritual kesandingan merupakan sesuatu yang sakral dan mistis yang dilakukan orang tua saat anak batita (bawah tiga tahun) mengalami sakit panas berhari-hari, rewel, kerap menangis dan tidak bisa tidur terutama malam hari. Tujuan penelitian ini untuk menjelaskan proses komunikasi simbolik ritual kesandingan dan memahami makna simbolik dibalik ritual tersebuat. Penelitian ini merupakan penelitian deskriptif-kualitatif, pengumpulan datanya melalui observasi, wawancara mendalam, dan dokumentasi. Sedangkan analisis datanya menggunakan teknik analisa data kualitatif-naturalistik. Sebagai hasilnya, diketahui bahwa proses komunikasi simbolik ritual kesandingan di desa Mentor Kecamatan Sumberasih Kabupaten Probolinggo meliputi tujuh rangkaian yaitu: membakar kemenyan, mengusap asap kemenyan ke wajah anak, memberi minuman kepada anak dengan air doa, mengusap wajah anak dengan air bunga, menyiapkan makanan, memanjatkan doa ditempat tidur anak, dan membagikan makanan. Sedangkan makna simbolik ritual kesandingan mencakup tiga dimensi, yaitu: dimensi ketuhanan, sosial, dan personal.
La Sociedad Brasileña de Educación Matemática y la Base Nacional Común Curricular
Authors: Dias Marcelo de Oliveira 
Published: June 2021

La Base Nacional Común Curricular brasileña [BNCC], creada entre 2015 y 2018, está constituida por documentos curriculares determinados, cuyo proceso de construcción presentó fuertes componentes políticos y fue centro de conflictos y tensiones en el contexto educativo del país. El enfoque de ciclo de políticas, formulado por Ball, ha sido usado con frecuencia por investigadores de políticas curriculares, entre otros campos. Este enfoque es una tendencia metodológica relevante para la comprensión de procesos de reforma curricular a partir de los contextos de producción e influencia de la BNCC, así como de los paradigmas que dirigieron esa construcción y de las tensiones ideológicas producto de la participación de organismos multilaterales. Para lograr tal objetivo, este artículo presenta un análisis de las posiciones provenientes de documentos públicos y de entrevistas con un representante de la Sociedad Brasileña de Educación Matemática en momentos específicos durante el proceso de construcción del documento establecido para el aprendizaje de matemáticas en Brasil. Los análisis evidenciaron una necesidad de reflexionar sobre los modelos verticales, las voces silenciadas y los contenidos matemáticos como instrumentos de gestión y performatividad impresos en la reforma.
LIMNOLOGICAL ASPECTS OF A SHALLOW POND USED AS RECEIVER AQUACULTURE WASTES AND FOR AGRICULTURAL IRRIGATION
Authors: SIPAÚBA-TAVARES Lúcia Helena , SILVA Juliane dos Santos Alves da , MILLAN Rodrigo Ney , MENDONÇA Gislaine Costa de 
Published: June 2021

Water samples, zooplankton community and sediment samples were analyzed at three sites in a pond receiving wastes, bi-weekly for seven months, covering the rainy and dry seasons. Water quality parameters failed to show significant differences between the sites for turbidity, total suspended solids, dissolved oxygen, transparency, conductivity, alkalinity and total phosphorous. Only temperature was different between the seasons. In the case of sediment, only aluminum (Al) was not different during the experimental period when highest calcium (Ca) concentrations were reported. The relative abundance of Rotifera during the sampling period reached 80-96% (rainy season) and 59-98% (dry season) in total zooplankton. Current study demonstrated that the water quality of shallow pond associated with allochthonous materials from aquaculture farm significantly influenced the structure of zooplankton assemblage due to high nutrient concentrations, conductivity, alkalinity and chlorophyll-a causing more fertilized water. However, heavy rains (February-April) and continuous water flow favored aeration (dissolved oxygen >5.2 Â± 1 mg L-1). The use of pond water for agricultural irrigation or for other purposes, must be analyzed more effectively, avoiding problems caused by its usage.
EFFECT OF CONJUGATED LINOLEIC ACID FEEDING PERIODS ON FATTY ACID PROFILE AND NUTRITIONAL QUALITY OF <i>Astyanax altiparanae</i>
Authors: OLIVEIRA Katia Rodrigues Batista de , CAMPELO Daniel Abreu Vasconcelos , BATISTON Weliton Pedro , FURUYA Wilson Massamitu , ZUANON Jener Alexandre Sampaio , CARNEIRO Antônio Policarpo Souza , FERRAZ Renato Barbosa , SALARO Ana Lúcia 
Published: June 2021

The effects of feeding diets with conjugated linoleic acid (CLA) to Astyanax altiparanae for different periods were investigated on carcassesââ‚¬â„¢ fatty acid profile and nutritional quality. The trial was laid out in a complete randomized design with eight feeding periods (0, 7, 14, 21, 28, 35, 42, and 49 days) and four replicates. A total of 240 fish (3.4 Â± 0.3 g) were distributed into four aquariums and fed with the diet containing 32% crude protein, 15 MJ kg-1 gross energy, and 2.5% of CLA. Feeding CLA diet for 49 days resulted in the higher deposition of CLA, CLA isomers, and docosahexaenoic acid (DHA). The isomer c9,t11 was highly deposited than the t10,c12. Polyunsaturated fatty acids (PUFA), n-3, and n-6 increased with feeding period, whereas saturated (SFA), monounsaturated, and medium-chain fatty acids decreased. PUFA/SFA ratio, DHA/EPA, EPA+DHA, and thrombogenicity index increased linearly. Whereas atherogenicity index reduced, hypocholesterolemic/hypercholesterolemic ratio increased in quadratic effects over feeding time. No difference was observed for the n-6/n-3 ratio. Feeding A. altiparanae with 2.5% of CLA for a minimum of 35 days improves the fatty acid profile and provides a commercial product with good nutritional quality and functional benefits.