bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence, etiology, and course of hypercalcemia-induced AKI in a tertiary care center from northern India
Authors: Bhat Nucksheeba Aziz , Mustafa Farhat , Sheikh Rayees Yousuf , Wani Imtiyaz 
Published: November 2021

Abstract
Background
Hypercalcemia is known to cause acute kidney injury (AKI). Literature related to hypercalcemic AKI is predominantly in the form of case reports and case series. The purpose of this study is to find the incidence, etiology, and course of hypercalcemia-induced AKI in a non-critical care setting. To our knowledge, this is the first study done to look for the incidence, etiology, and course of hypercalcemia-induced AKI in a non-critical care setting. This is a prospective observational study conducted in the Department of Medicine in a tertiary care center from Jammu and Kashmir, India, from June 2010 to June 2012. Patients admitted with hypercalcemia were assessed for AKI and evaluated and treated for hypercalcemia. Renal function was monitored during hospitalization and at 1 month of discharge. AKI and hypercalcemia were arbitrarily defined as serum creatinine > 1.5 mg/dl and corrected serum calcium of ≥ 11.5 mg/dl (as per reference hospital lab), respectively.

Results
Thirty patients are included. Hyperparathyroidism and multiple myeloma accounted for 13(43.3%) and 10 (33.3%) cases, respectively. Mean ±SD corrected serum calcium at diagnosis and after treatment at 1 month was 13.56 ± 1.86 mg/dl and 9.49±1.35 mg/dl, respectively; p < 0.001. Mean ±SD serum creatinine at baseline and after treatment of hypercalcemia was 2.87 ±1.68 mg/dl and 1.49±1.34 mg/dl, respectively; p < 0.001. Twenty-three (76.7%) patients had AKI. AKI recovered after treating hypercalcemia in 25 (83.3 %) patients. Mean ± SD days taken for the decrease in serum creatinine to ≤ 1.5 mg/dl was 8.28 ± 4.17 days. Mean ± SD serum creatinine after treatment of hypercalcemia in hyperparathyroidism group versus non-parathyroid group was 0.97 ± 0.35 mg/dl and 1.88 ±1.67 mg/dl, respectively; p value 0.009.

Conclusions
Hypercalcemia is commonly associated with AKI. Primary hyperparathyroidism and multiple myeloma account for the majority of the cases. Hypercalcemic AKI with primary hyperparathyroidism is less common and the outcome is better, as compared to non-hyperparathyroidism-related causes. AKI is reversible in most cases.
Longer-term mortality following SARS-CoV-2 infection in people with severe mental illness: retrospective case-matched study
Authors: Chen Shanquan , Fernandez-Egea Emilio , Jones Peter B. , Lewis Jonathan R. , Cardinal Rudolf N. 
Published: November 2021

Summary
Persisting symptoms and dysfunction after SARS-CoV-2 infection have frequently been observed. However, information on the aftermath of COVID-19 is inadequate. We followed up people with severe mental illness (SMI) infected with SARS-CoV-2, and evaluated their longer-term mortality, using data from Cambridgeshire and Peterborough NHS Foundation Trust, UK. We examined the time course and duration of mortality risk from the point of diagnosis. After SARS-CoV-2 infection, people with SMI had a substantially higher risk of death (hazard ratio (HR) = 5.16, 95% confidence interval (CI) 1.56–17.03; P = 0.007) during the first 28 days and during the following 28–60 days (HR = 2.96, 95% CI 1.21–7.26; P = 0.018) than those without infection, but after 60 days the additional risk of death was no longer significant (HR = 2.33, 95% CI 0.83–6.53; P = 0.107).
Randomized Phase III Study of Gefitinib Versus Cisplatin Plus Vinorelbine for Patients With Resected Stage II-IIIA Non–Small-Cell Lung Cancer With EGFR Mutation (IMPACT)
Authors: Tada Hirohito , Mitsudomi Tetsuya , Misumi Toshihiro , Sugio Kenji , Tsuboi Masahiro , Okamoto Isamu , Iwamoto Yasuo , Sakakura Noriaki , Sugawara Shunichi , Atagi Shinji , Takahashi Toshiaki , Hayashi Hidetoshi , Okada Morihito , Inokawa Hidetoshi , Yoshioka Hiroshige , Takahashi Kazuhisa , Higashiyama Masahiko , Yoshino Ichiro , Nakagawa Kazuhiko ,   for the West Japan Oncology Group
Published: November 2021

PURPOSE To investigate the efficacy of gefitinib as an adjuvant therapy for non–small-cell lung cancer patients with EGFR mutation. PATIENTS AND METHODS IMPACT (WJOG6410L; University Hospital Medical Information Network Clinical Trials Registry: UMIN000006252 ), a randomized, open-label, phase III study, included patients with completely resected pathologic stage II-III non–small-cell lung cancer harboring EGFR mutations (exon 19 deletion or L858R) during September 2011 to December 2015. Patients were randomly assigned to receive gefitinib (250 mg once daily) for 24 months or cisplatin (80 mg/m2 on day 1) plus vinorelbine (25 mg/m2 on days 1 and 8; cis/vin) once every 3 weeks for four cycles. The primary end point was disease-free survival (DFS). RESULTS Overall, 234 patients were randomly assigned. Among 232 eligible patients (116 each; excluding two who withdrew consent), the median DFS was 35.9 and 25.1 months in the gefitinib and cis/vin groups, respectively. However, Kaplan-Meier curves crossed around 4 years after surgery with no statistically significant difference (stratified log-rank P = .63; hazard ratio by stratified Cox proportional hazards model = 0.92; 95% CI, 0.67 to 1.28). Overall survival (OS) was also not different (stratified log-rank P = .89; hazard ratio = 1.03; 95% CI, 0.65 to 1.65), with the 5-year OS rates being 78.0% and 74.6% in the gefitinib and cis/vin groups, respectively. Treatment-related deaths occurred in 0 and three patients in the gefitinib and cis/vin groups, respectively. CONCLUSION Although adjuvant gefitinib appeared to prevent early relapse, it did not prolong DFS or OS. However, similar DFS and OS may justify adjuvant gefitinib in the selected patient subsets, especially those deemed ineligible for platinum-doublet adjuvant therapy; however, this was not a noninferiority trial.
The Proteomic Signature of Recombinant Growth Hormone in Recreational Athletes
Authors: Esefeld Max , Pastor Antoni , de la Torre Rafael , Barroso Osquel , Aikin Reid , Sarwath Hina , Engelke Rudolf , Schmidt Frank , Suhre Karsten 
Published: November 2021

Abstract

Objective
Administration of human growth hormone (hGH) is prohibited in competitive sport and its detection in an athlete’s sample triggers an adverse analytical finding. However, the biological processes that are modulated by recombinant hGH are not well characterized and associated blood serum proteins may constitute new biomarkers for hGH misuse.

Methods
Thirty-five recreational athletes were enrolled in a study to investigate the time- and dose-dependent response of serum protein levels to recombinant hGH administration. Participants were randomly assigned to 4 groups, receiving 1 of 3 different doses of recombinant hGH or a placebo. Bio samples were collected at 22 time points over a period of 13 weeks, starting 4 weeks before treatment, during 3 weeks of treatment, and at 6 weeks’ follow-up. A total of 749 serum samples were analyzed for 1305 protein markers using the SOMAscan proteomics platform.

Results
We identified 66 proteins that significantly associated with recombinant hGH administration and dosage, including well known hGH targets, such as IGF1, but also previously unknown hGH-related proteins (eg, protease inhibitors, WFIKKN1, and chemokines, CCL2). Network analysis revealed changes in specific biological pathways, mainly related to the immune system and glucose metabolism.

Conclusion
Our analysis suggests that hGH administration affects biological processes more strongly than previously acknowledged. Some of the proteins were dysregulated even after hGH treatment and could potentially be developed into biomarkers for hGH misuse. Moreover, our findings suggest new roles for hGH-associated proteins in the etiology of hGH-related diseases and may indicate new risks that may be associated with hGH misuse.
Hopes for Reading in the Era of Globalization
Authors: Falke Cassandra 
Published: November 2021

AbstractThis article identifies in contemporary literary theory a new optimism about the power of literary texts. The medium of this power is not language, ideology, or form but readers open to being changed. Drawing on phenomenology, the article discusses methods for making literary theory students open to and aware of such change, suggesting that hope is the grounding condition for any effective teaching act as well as an effective ground for reading in an era of globalization.
Embodying an artificial hand increases blood flow to the investigated limb
Authors: Di Pino Giovanni , Mioli Alessandro , Altamura Claudia , D'Alonzo Marco 
Published: November 2021

Background: The autonomic nervous system is the main determinant of the blood flow directed towards a body part, and it is tightly connected to the representation of the body in the brain; would the experimental modulation of the sense of ownership of the limb affect its blood perfusion? Methods: In healthy participants, we employed the rubber hand illusion paradigm to modulate limb ownership while we monitored the brachial artery blood flow and resistance of the investigated limb. Results: In all conditions with brush-stroking, we found an initial drop in the blood flow due to tactile stimulation. Subsequently, in the illusion condition where both the rubber and real hand experience synchronous brush-stroking, the blood flow rose significantly faster and reached significantly higher values. Moreover, the increase in blood flow correlated to the embodiment level measured by questionnaires and, negatively, to the change of peripherical vascular resistance. Conclusions: These findings demonstrate that modulating the representation of a body part impacts its blood perfusion.
On the Dose Coefficient of Uranium Hexafluoride
Authors: Babenko S. , Bad'in A. 
Published: November 2021

Introduction: Uranium hexafluoride (UF6, UHF) is a gaseous product containing uranium and fluorine. Once in the air, it interacts with water vapor and produces hydrolysis products that can penetrate the human body and lead to the chemical effects of uranium and fluorine, as well as the radiation effects of uranium on the body. This action can be very strong and therefore serious attention has been paid to its study for a long time.
Purpose: Quantitative calculation of the radiation effects of uranium on humans and their analysis in the conditions of daily work at nuclear power plants, as well as in emergency situations.
Material and methods: We consider uranium hexafluoride that appears under certain conditions in the air of the working rooms of some enterprises and describes methods for describing the distribution of UHF hydrolysis products to objects that can sense their effects. All these methods are combined into a single integrated model. The analytical expressions obtained in the framework of this model at various stages are given, which make it possible to calculate the radiation effect of UHF.
Results: The calculated values of the characteristics of the radiation exposure are given, their analysis is carried out. The conditions are formulated under which there is a danger of serious radiation exposure of uranium hexafluoride to employees of nuclear power plants during everyday work and in emergency situations.
Conclusion: Based on all the material presented, it is concluded that the constructed mathematical model reliably describes the event in question and allows us to calculate the radiation effect of uranium on humans.
Influence of Powerful Non-Ionizing Terahertz Radiation on Healthy and Tumor Human Cells of Neural Origin
Authors: Shatalova R. , Gurova S. , Revkova V. , Ilina I. , Sitnikov D. 
Published: November 2021

Purpose: Study of the influence of high-power pulses of coherent non-ionizing terahertz (THz) radiation on the formation of foci of double-strand DNA breaks and the proliferative activity of human neuronal cells.
Material and methods: Irradiated cell cultures are direct reprogramming neural progenitor cells (drNPCs), neuroblastoma cells (SK-N-BE). Cells are irradiated with a sequence of THz radiation pulses with a peak intensity of ~ 20 GW/cm2 and electric field strength of 2.8 MV/cm. Irradiation lasts 30 mins.
Results: There is no statistically significant difference in the number of γH2AX histone foci between experimental and control cell groups.
Conclusion: It was shown that a short exposure (30 min) of cells to THz radiation with intensity of 20 GW/cm2 does not affect the proliferative activity of both neural progenitor cells and neuroblastoma cells and does not cause a significant increase in γH2AX foci in any of the studied cell lines.
Near ground horizontal high resolutionCn2 profiling from Shack–Hartmann slopeand scintillation data
Authors: Sauvage C. , Robert C. , Mugnier L. M. , Conan J.-M. , Cohard J.-M. , Nguyen K.-L. , Irvine M. , Lagouarde J.-P. 
Published: November 2021

Coupled slope and scintillation detection and ranging (CO-SLIDAR) is a very promising technique for the metrology of near groundCn2profiles. It exploits both phase and scintillation measurements obtained with a dedicated wavefront sensor and allows profiling on the full line of sight between pupil and sources. This technique is applied to an associated instrument based on a mid-IR Shack–Hartmann wavefront sensor coupled to a 0.35 m telescope, which observes two cooperative sources. This paper presents what we believe is the first comprehensive description of the CO-SLIDAR method in the context of near-ground optical turbulence metrology. It includes the presentation of the physics principles underlying the measurements of our unsupervisedCn2profile reconstruction strategy together with the error bar estimation on the reconstructed values. The application to data acquired in a heterogeneous rural landscape during an experimental campaign in Lannemezan, France, demonstrates the ability to obtain profiles with a sampling pitch of about 220 m over a 2.7 km line of sight. The retrievedCn2profiles are presented and their variability in space and time is discussed.
Linear scanning system for THz imaging
Authors: Shchepetilnikov A. V. , Gusikhin P. A. , Muravev V. M. , Kaysin B. D. , Tsydynzhapov G. E. , Dremin A. A. , Kukushkin I. V. 
Published: November 2021

A linear scanning system utilizing constant wave 280 GHz radiation has been developed and characterized. The system comprises a linear array of detectors based on a unique plasma wave approach in terahertz sensing, an impact ionization avalanche transit-time-diode signal generator coupled to a frequency multiplier and an optical system. The performed tests allowed us to estimate the resolution of the system reaching the value of 2.3 mm and to determine the dynamic range of the system to be around 200. The imaging capabilities of the scanner were tested in realistic cases of non-destructive testing and security screening.
The Science of Writing Characters, Kira-Anne Pelican (2020)
Authors: Gulino Paul 
Published: November 2021

Review of: The Science of Writing Characters, Kira-Anne Pelican (2020)
New York: Bloomsbury Academic, 200 pp.,
ISBN 978-1-50135-724-4, p/bk, $26.95; h/bk, $90.00; Kindle, $24.25
Atención farmacéutica en probióticos y estimulación inmunitaria en una oficina de farmacia de Salamanca durante los meses de septiembre a enero de 2020
Authors: Rodríguez Isabel , Martín Crisanto 
Published: November 2021

El sistema inmune y la microbiota constituyen la primera línea de defensa del organismo contra patógenos, por lo que su buen funcionamiento es esencial para nuestra salud.
La microbiota es el conjunto de los numerosos microorganismos que residen en nuestro organismo, y cuando esta se ve alterada se pueden desarrollar diversas patologías. Por ello, los probióticos, prebióticos y simbióticos tienen un papel muy importante como tratamiento preventivo o como coadyuvante ayudando a reequilibrar nuestra microbiota, además de poseer un destacable efecto inmunomodulador.
Para recomendar o consumir un producto probiótico de forma adecuada debemos tener en cuenta la cepa y la dosis para cada patología a tratar, ya que, de lo contrario, la eficacia podría no ser la esperada.
En este estudio se tratará de comprobar el conocimiento y el uso de los probióticos en la población de una farmacia comunitaria, verificar su eficacia y detectar posibles efectos adversos, además de fomentar la educación sanitaria por parte del farmacéutico.
Smart-Specialization of the Agro-Industrial Complex in the Context of Digital Transformation of Regional Economic Systems
Authors: Kulik Anna M , Lavrinenko Elena A , Lyshchikova Julia V , Stryabkova Elena A 
Published: November 2021

This article presents a domestic and foreign experience of "smart specialization" in agriculture in the digital economy. The method of calculating the indicators of digital maturity of the agro-industrial complex is considered. The forecast of indicators value of the agro-industrial digital maturity is presented until 2030. The article proposes a mechanism for adapting the smart specialization in agriculture. We consider it appropriate to introduce an online digital platform in agriculture, which allows creating conditions for interaction between sellers and buyers of regional agricultural machinery and related products. Based on the presented mechanism of adaptation of "smart specialization "in the field of agro-industrial complex, it should be noted that" smart specialization" is aimed at using the links that arise between the regions of economic activity. The priority areas of activity of the agro-industrial complex are presented.JEL Classification: L52, Q16, R11How to Cite:Kulik, A. M., Lavrinenko, E. A., Lyshchikova, J. V., & Strybkova, E. A. (2021). Smart-Specialization of the Agro-Industrial Complex of Digital Transformation of Regional Economic System. Etikonomi, 20(2), xx– xx. https://doi.org/10.15408/etk.v20i2.22015.
Improving Opioid Stewardship in Pediatric Emergency Medicine
Authors: Lavingia Richa , Mondragon Ealing , McFarlane-Johansson Nina , Shenoi Rohit P. 
Published: November 2021

OBJECTIVES
Poor opioid stewardship contributes to opioid misuse and adverse health outcomes. We sought to decrease opioid prescriptions in children 0 to 18 years treated for pain after fractures and cutaneous abscess drainage from 13.5% to 8%. Our secondary aims were to reduce opioid prescriptions written for &gt;3 days from 41% to 10%, eliminate codeine prescriptions, increase safe opioid storage and disposal discharge instructions from 0% to 70%, and enroll all emergency department (ED) physicians in the state prescription drug monitoring program.

METHODS
We implemented an intervention bundle on the basis of 4 key drivers at a pediatric ED: ED-wide education, changes in the electronic medical record, discharge resources, and process standardization. Two plan-do-study-act cycles were performed. Interventions included provider feedback on prescribing, safe opioid storage and disposal instructions, and streamlined electronic medical record functions. Run charts were used to analyze the effect of interventions on outcomes. Our balance measure was return ED or clinic visits for inadequate analgesia within 3 days.

RESULTS
During the intervention period, 249 of 3402 (7.3%) patients with fractures and cutaneous abscesses were prescribed opioids. The percentage of opioid prescriptions &gt;3 days decreased from 41% to 13.2% (P &lt; .0001), codeine prescription dropped from 1.1% to 0% (P = .09), opioid discharge instructions increased 0% to 100% (P &lt; .0001), and all physicians enrolled in the prescription drug monitoring program. There was no change in return visits for uncontrolled analgesia compared with the baseline (P = .79).

CONCLUSIONS
A comprehensive opioid stewardship program can improve opioid prescribing practices of ED physicians and deliver information on safe storage and disposal of prescription opioids with a negligible effect on return visits for uncontrolled pain.
Promoting the future of innovative higher education through thousands of master's programmes
Authors: Feher Katalin , Géring Zsuzsanna , Király Gábor 
Published: November 2021

Abstract
This paper discusses how leading innovative universities and their master's programmes reflect rapidly changing social-economic technological trends. The increasing focus on the STEM subjects, the changing profile of business and MBA programmes, and the ratio of interdisciplinarity provide insights into the development of future-oriented higher education. In the scope of this study, 2,708 master's programmes were surveyed globally based on their online representation, and 1,750 training programmes from this list were analysed in terms of employability rankings. According to our findings, Western Europe offers the largest number of master's programmes. STEM studies are overrepresented at the top innovative universities, and interdisciplinary studies account for fifteen percent of the programmes. Additionally, business studies with interdisciplinary programmes were identified in a higher proportion as compared to business-only studies. The findings signal the labour market's preferences toward future-oriented, personalised and responsive knowledge. The present study contributes to future education through a global analysis, and supports the strategy creation of higher education institutions (HEIs). Therefore, this article is especially informative to representatives, policy makers or researchers at future-oriented HEIs.
Fertilization optimization algorithm on CEC2015 and large scale problems
Authors: Nasir Ghafil Hazim , Alsamia Shaymaa , Jármai Károly 
Published: November 2021

Abstract
This work, presents a novel optimizer called fertilization optimization algorithm, which is based on levy flight and random search within a search space. It is a biologically inspired algorithm by the fertilization of the egg in reproduction of mammals. The performance of the algorithm was compared with other optimization algorithms on CEC2015 time expensive benchmarks and large scale optimization problems. Remarkably, the fertilization optimization algorithm has overcome other optimizers in many cases and the examination and comparison results are encouraging to use the fertilization optimization algorithm in other possible applications.
Investigation of scours on a physical model of the Hričov weir using photogrammetry
Authors: Pavúček Martin , Rumann Ján , Dušička Peter 
Published: November 2021

Abstract
Scours creation in riverbed at the Hričov weir is a permanent problem since its construction. It is caused by the shortened stilling basin of the weir. In almost all cases of flow control at the weir the energy is not dissipated sufficiently. A 3D physical model was built in the hydraulic laboratory to investigate the measures for reduction of the scour creation. To simulate uneven loads on the downstream riverbed, a flood discharge controlled by the weir in symmetric and asymmetric operations was used for simulations. The scours were evaluated using short-range photogrammetry for contactless measurements. Based on this method digital models of the riverbed for each simulation were created and the scours were assessed to determine the effect of the investigated measures on scour reduction.