bluuebunny/crossref_metadata_2025_split huggingface dataset:
The“ArgentineFranco”?:The Regime of Juan Carlos Onganía and Its Ideological Dialogue with Francoist Spain (1966–1970)
Authors: Kressel Daniel G. 
Published: January 2021

AbstractThe article examines the ideological character of Juan Carlos Onganía's dictatorship by exploring its ties and dialogue with Francisco Franco's Spain. Known as the “Argentine Revolution,” Onganía's regime (1966-70) was, the article shows, one of the first Cold War Latin American dictatorship to overtly use Francoist ideology as its point of reference. While building on the conventional wisdom that the legacies of the Spanish Civil War informed right-wing thought in Latin America, the study then shifts its focus to Spain's 1960s “economic miracle” and technocratic state model, observing them as a prominent discursive toolkit for authoritarian Argentine intellectuals. Drawing on newly discovered correspondence and archival sources, the article first excavates the intellectual networks operating between Franco's Spain and the Argentine right during the 1950s and 1960s. Once handpicked by Onganía to design his regime, these Argentine Franco-sympathizers were to decide the character of the Argentine Revolution. Second, the article sheds light on the intimate collaboration between the two dictatorships, and further explores the reasons for Onganía's downfall. In doing so, the study adds to a burgeoning historiographic field that underscores the significance of the Francoist dictatorship in the Latin American right-wing imaginary.
TheTwo, theOne, theMany, theNone:Rethinking the Republics of Spaniards and Indians in the Sixteenth-Century Spanish Indies
Authors: Masters Adrian 
Published: January 2021

AbstractFor a half-century, the historiography on Spanish Habsburg rule suggested that the crown envisioned Indies society as best divided into two segregated sociolegal groups: the republic of the Spaniards and the republic of the Indians. This model was popularized by the eminent mid twentieth century Swedish historian Magnus Mörner and has since become a foundational concept in the field. However, using extensive archival evidence, this article suggests that the Mörner Thesis of the Two Republics is flawed. Historicizing sixteenth-century uses of the concept of the republic, it finds that contemporaries conceived of a complex social order in which many political communities such as municipalities and groups of petitioners could overlap within larger meta-republics, such as the Indies republic and the Christian faith-republic. It then turns to subjects’ uses of the two republics, noting that this conceptual duality appeared rarely in the petitions of Spanish officials, commoners, Indians, Afro-descendants, and mestizos, and was also rare in royal and viceregal legislation. Moreover, this binary most often served to suggest Spaniards’ and Indians’ common ground. The article then reflects on other approaches to understanding the Indies’ Spanish-Indian binary, the place of non-Spanish, non-Indian vassals within republic-thinking, and the staggering complexity of Indies laws, categories, and social interactions.
Particle Acceleration by Dense Impulsive Structures Moving in Ambient Magnetospheric Plasma. 3‐D Hybrid Kinetic Modeling and MMS Observations
Authors: Lipatov A. S. , Avanov L. A. , Giles B. L. 
Published: January 2021

AbstractHigh resolution observations of dense plasma impulsive structures moving through an ambient background magnetospheric flows were captured by the Magnetospheric Multiscale mission. The observations show particle heating and acceleration, shock‐like wave formation, and whistler wave excitation inside the interface between the dense impulsive plasma structures and the ambient plasma. A multiscale hybrid kinetic simulation provides an explanation of the observed wave‐particle interactions with the assumption that the dense plasma structures may be represented by plasma clouds which are formed at the magnetopause layer due to reconnection processes.
Subdiurnal to Interannual Frequency Analysis of Observed and Modeled Reflected Shortwave Radiation From Earth
Authors: Feldman D.R. , Su W. , Minnis P. 
Published: January 2021

AbstractEstimates of global top‐of‐atmosphere radiation on monthly, seasonal, annual, and longer time‐scales require estimates of the diurnal variability in both insolation and surface and atmospheric reflection. We compare Earth Polychromatic Imaging Camera (EPIC) and National Institute of Standards and Technology Advanced Radiometer (NISTAR) observations from the Deep Space Climate Observatory (DSCOVR) satellite with Clouds and Earth’s Radiant Energy System (CERES) hourly synoptic fluxes, which are diurnally filled through geostationary observations, and find that their power spectral density functions substantially agree, showing strong relative power at subdiurnal, diurnal, seasonal, and annual time‐scales, and power growing from diurnal to seasonal time‐scales. Frequency analysis of fluxes from several coupled model intercomparison project 5 model (CMIP5) and CMIP6 models shows that they distribute too much power over periods greater than 1 day but less than one year, indicating that a closer look is needed into how models achieve longer‐term stability in reflected shortwave radiation. Model developers can consider using these datasets for time‐varying energetic constraints, since tuning parameter choices will impact modeled planetary shortwave radiation across timescales ranging from subdiurnal to decadal.
Decadal Disruption of the QBO by Tropical Volcanic Supereruptions
Authors: Brenna Hans , Kutterolf Steffen , Mills Michael J. , Niemeier Ulrike , Timmreck Claudia , Krüger Kirstin 
Published: January 2021

AbstractThe Los Chocoyos (14.6°N, 91.2°W) supereruption happened ∼75,000 years ago in Guatemala and was one of the largest eruptions of the past 100,000 years. It emitted enormous amounts of sulfur, chlorine, and bromine, with multi‐decadal consequences for the global climate and environment. Here, we simulate the impact of a Los Chocoyos‐like eruption on the quasi‐biennial oscillation (QBO), an oscillation of zonal winds in the tropical stratosphere, with a comprehensive aerosol chemistry Earth System Model. We find a ∼10‐year disruption of the QBO starting 4 months post eruption, with anomalous easterly winds lasting ∼5 years, followed by westerlies, before returning to QBO conditions with a slightly prolonged periodicity. Volcanic aerosol heating and ozone depletion cooling leads to the QBO disruption and anomalous wind regimes through radiative changes and wave‐mean flow interactions. Different model ensembles, volcanic forcing scenarios and results of a second model back up the robustness of our results.
Changes in Hourly Extreme Precipitation Over Eastern China From 1970 to 2019 Dominated by Synoptic‐Scale Precipitation
Authors: Ng Chan‐Pang , Zhang Qinghong , Li Wenhong 
Published: January 2021

AbstractBecause of its dense population, extreme precipitation, in particular hourly extreme precipitation (HEP), is receiving increasing attention from both academic and public bodies in eastern China. Based on a continuous 50‐year record of hourly precipitation and reanalysis data, we show here for the first time that changes in the HEP occurrence are dominated by changes in the duration of the Meiyu front system. Further analyses reveal that greater occurrence of HEP in northeastern China, the lower reach of Yangtze River, and southern China during the warm season is largely due to a longer duration of the post‐Meiyu I stage when Meiyu front stays in northern China and meridional circulation dominates the eastern coastal area of China. These results improve our understanding of the changing behavior of extreme rainfall in China and shed light on the prevention of flash floods.
Spatial Patterns and Drivers of Nonperennial Flow Regimes in the Contiguous United States
Authors: Hammond John C. , Zimmer Margaret , Shanafield Margaret , Kaiser Kendra , Godsey Sarah E. , Mims Meryl C. , Zipper Samuel C. , Burrows Ryan M. , Kampf Stephanie K. , Dodds Walter , Jones C. Nathan , Krabbenhoft Corey A. , Boersma Kate S. , Datry Thibault , Olden Julian D. , Allen George H. , Price Adam N. , Costigan Katie , Hale Rebecca , Ward Adam S. , Allen Daniel C. 
Published: January 2021

AbstractOver half of global rivers and streams lack perennial flow, and understanding the distribution and drivers of their flow regimes is critical for understanding their hydrologic, biogeochemical, and ecological functions. We analyzed nonperennial flow regimes using 540 U.S. Geological Survey watersheds across the contiguous United States from 1979 to 2018. Multivariate analyses revealed regional differences in no‐flow fraction, date of first no flow, and duration of the dry‐down period, with further divergence between natural and human‐altered watersheds. Aridity was a primary driver of no‐flow metrics at the continental scale, while unique combinations of climatic, physiographic and anthropogenic drivers emerged at regional scales. Dry‐down duration showed stronger associations with nonclimate drivers compared to no‐flow fraction and timing. Although the sparse distribution of nonperennial gages limits our understanding of such streams, the watersheds examined here suggest the important role of aridity and land cover change in modulating future stream drying.
Partitioning Net Ecosystem Exchange (NEE) of CO2 Using Solar‐Induced Chlorophyll Fluorescence (SIF)
Authors: Kira O. , Y‐Y. Chang C. , Gu L. , Wen J. , Hong Z. , Sun Y. 
Published: January 2021

AbstractAccurate partitioning of net ecosystem exchange (NEE) of CO2 to gross primary production (GPP) and ecosystem respiration (Reco) is crucial for understanding carbon cycle dynamics under changing climate. However, it remains as a long‐standing problem in global ecology due to lack of independent constraining information for the two offsetting component fluxes. solar‐induced chlorophyll fluorescence (SIF), a mechanistic proxy for photosynthesis, holds great promise to improve NEE partitioning by constraining GPP. We developed a parsimonious SIF‐based approach for NEE partitioning and examined its performance using synthetic simulations and field measurements. This approach outperforms conventional approaches in reproducing simulated GPP and Reco, especially under high vapor pressure deficit. For field measurements, it results in lower daytime GPP and Reco than conventional approaches. This study made the first attempt to demonstrate SIF's potential for improving NEE partitioning accuracy and sets the stage for future efforts to examine its robustness and scalability under real‐world environmental conditions.
RESET: A Method to Monitor Thermoremanent Alteration in Thellier‐Series Paleointensity Experiments
Authors: Wang Huapei , Kent Dennis V. 
Published: January 2021

AbstractAccurately estimating the paleomagnetic field intensity recorded in terrestrial and planetary materials is the key to understanding dynamo processes. Thellier‐series stepwise‐heating methods with partial thermoremanent magnetization (pTRM) checks for alteration are considered the most reliable technique even though pTRM checks are shown to be incapable of detecting the entirety of thermal alteration. We utilize a recently developed multidomain‐correction experiment (or RESET) to monitor thermally induced magnetic property alteration that may happen to the very specimen used in Thellier‐series experiments. We also use rock magnetic property changes to track the physicochemical alteration of fresh companion specimens of Galapagos lavas that were previously used for paleointensity determinations. Our results show that laboratory heating induced thermal alteration of a typical Galapagos lava sample starts to occur at around 500°C. It escaped detection by pTRM checks but was caught by our RESET method.
The Role of Cloud Processing for the Ice Nucleating Ability of Organic Aerosol and Coal Fly Ash Particles
Authors: Kilchhofer Kevin , Mahrt Fabian , Kanji Zamin A. 
Published: January 2021

AbstractIce nucleating particles are a minor fraction of tropospheric aerosol, yet they play a key role for cloud microphysical processes. One poorly understood process is the impact of atmospheric aging of aerosol particles on ice nucleation. Here we study the impact of cloud processing on the ice nucleation abilities of two physicochemically different aerosol particles by taking two model systems for atmospheric organic aerosol (OA), as well as coal fly ash (CFA) particles representing an inorganic aerosol type. The ice nucleation activity of the unprocessed particles is compared to aerosol particles that are first exposed to conditions mimicking trajectories though cirrus clouds (CC) and mixed‐phase clouds (MPC) prior to testing their ice nucleation activity at temperatures below 243 K. We observed that unprocessed OA do not exhibit heterogeneous ice nucleation, requiring homogeneous freezing conditions of solution droplets to form ice. However, after CC processing raffinose particles showed heterogeneous ice nucleation activity at 218 K and a water saturation ratio of 0.68–0.82, reaching activated fractions of up to 0.3. This enhancement compared to unprocessed raffinose particles results from an increase in particle viscosity upon CC processing. We also present new results of unprocessed CFA particles exhibiting strong heterogeneous ice nucleation activity at temperatures below 235 K in the deposition and/or pore condensation and freezing mode. In contrast to the OA, the CFA show a decrease in ice nucleation activity after both MPC and CC processing. Furthermore, cloud processing and generating CFA particles from aqueous suspensions do not have the same effect on their ice nucleation ability.
Association of the Zonal Migration of North Pacific Storm Track With the East Asian Monsoon in Boreal Wintertime
Authors: Yang Minghao , Li Chongyin , Li Xin , Tan Yanke , Wu Yue , Chen Xiong , Xia Fei 
Published: January 2021

AbstractThe winter North Pacific storm track (WNPST) distinctly manipulates weather and climate in the midlatitudes. Thus, it is necessary to comprehend the factors and related mechanisms governing the location and intensity of WNPST. In the present study, the influence of the East Asian winter monsoon (EAWM) on the zonal movement of the WNPST represented by the lower‐tropospheric meridional eddy heat flux is investigated, and the possible physical processes are analyzed. There is a significantly positive correlation, especially interannual signal, between the strength of the EAWM and the zonal position of the WNPST. The Liang‐Kleeman information flow theory is used to prove the mutual causality between the intensity of EAWM and the zonal migration of WNPST. The EAWM‐related intensity anomaly pattern of the WNPST, with prominently negative anomalies over the northwest Pacific and significantly positive anomalies over the northeast Pacific, is associated with the eastward movement of the WNPST. In addition, the results show that the patterns of anomalous lower‐tropospheric atmospheric baroclinicity and barotropic energy transfer do not match the EAWM‐related anomalous WNPST. The upper‐tropospheric jet anomalies may be related to the weakening in the peak area and the western flank of the climatological WNPST. The impact of the EAWM on the zonal movement of the WNPST can be related to the anomalous baroclinic energy transfer and buoyancy conversion. Furthermore, the moisture effect including anomalous meridional and vertical eddy moisture flux may also play a role by latent heat release.
Reconstructing Eocene Eastern Indian Ocean Dynamics Using Ocean‐Drilling Stratigraphic Records
Authors: Xu Ke , De Vleeschouwer David , Vahlenkamp Maximilian , Yang Renchao , Chen Honghan 
Published: January 2021

AbstractThe Eocene Epoch corresponds to the runup toward the Greenhouse to Icehouse Cenozoic transition. To fully appreciate this climate evolution, detailed and accurate age‐depth models are required. While much progress has been made recently in the field of Eocene astrochronology, the construction of unambiguous Eocene astronomical timescales (ATS) is hampered by lithologically undetected hiatuses, the scarcity of carbonate‐rich marine successions, and conflicting cyclostratigraphies. In this study, we present an orbital‐scale cyclostratigraphy for Ocean Drilling Program (ODP) Hole 762C, and we reconstruct Eastern Indian Ocean dynamics. This reconstruction is based on two ocean‐drilling Eocene sequences: ODP Hole 762C and International Ocean Discovery Program (IODP) Site U1514. Our eccentricity‐based cyclostratigraphy for Hole 762C is integrated with existing bio and magnetostratigraphies and constitutes the most precise available chronology for this legacy site. The Hole 762C stratigraphy is combined with the existing Site U1514 age‐depth model to obtain a high‐resolution Eocene ATS for the Eastern Indian Ocean. We apply sedimentary noise modeling to obtain new insights in benthic turbulence at both sites. Despite the significant difference in paleo‐waterdepth, noise levels at both sites carry a 1.2‐Myr obliquity amplitude imprint. We interpret the sedimentary noise at Hole 762C, on a submarine plateau, in terms of sea‐level change. The sedimentary noise at U1514, by contrary, is interpreted to be modulated by bottom current intensity as this site represents a deep‐sea basinal environment. We conclude that, despite very similar astronomical signatures, the mechanistic pathways between astronomical forcing and sedimentary response were radically different at these two sites.
Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1
Authors: Pan Jiongwei , Huang Gang , Yin Zhangyong , Cai Xiaoping , Gong Enhui , Li Yuling , Xu Cunlai , Ye Zaiting , Cao Zhuo , Cheng Wei 
Published: January 2021

AbstractSignificantly high-expressed circFLNA has been found in various cancer cell lines, but not in lung cancer. Therefore, this study aimed to explore the role of circFLNA in the progression of lung cancer. The target gene of circFLNA was determined by bioinformatics and luciferase reporter assay. Viability, proliferation, migration, and invasion of the transfected cells were detected by CCK-8, colony formation, wound-healing, and transwell assays, respectively. A mouse subcutaneous xenotransplanted tumor model was established, and the expressions of circFLNA, miR-486-3p, XRCC1, CYP1A1, and related genes in the cancer cells and tissues were detected by RT-qPCR, Western blot, or immunohistochemistry. The current study found that miR-486-3p was low-expressed in lung cancer. MiR-486-3p, which has been found to target XRCC1 and CYP1A1, was regulated by circFLNA. CircFLNA was located in the cytoplasm and had a high expression in lung cancer cells. Cancer cell viability, proliferation, migration, and invasion were promoted by overexpressed circFLNA, XRCC1, and CYP1A1 but inhibited by miR-486-3p mimic and circFLNA knockdown. The weight of the xenotransplanted tumor was increased by circFLNA overexpression yet reduced by miR-486-3p mimic. Furthermore, miR-486-3p mimic reversed the effect of circFLNA overexpression on promoting lung cancer cells and tumors and regulating the expressions of miR-486-3p, XRCC1, CYP1A1, and metastasis/apoptosis/proliferation-related factors. However, overexpressed XRCC1 and CYP1A1 reversed the inhibitory effect of miR-486-3p mimic on cancer cells and tumors. In conclusion, circFLNA acted as a sponge of miR-486-3p to promote the proliferation, migration, and invasion of lung cancer cells in vitro and in vivo by regulating XRCC1 and CYP1A1.
The androgen receptor/filamin A complex as a target in prostate cancer microenvironment
Authors: Di Donato Marzia , Zamagni Alice , Galasso Giovanni , Di Zazzo Erika , Giovannelli Pia , Barone Maria Vittoria , Zanoni Michele , Gunelli Roberta , Costantini Matteo , Auricchio Ferdinando , Migliaccio Antimo , Tesei Anna , Castoria Gabriella 
Published: January 2021

AbstractProstate cancer represents the major cause of cancer-related death in men and patients frequently develop drug-resistance and metastatic disease. Most studies focus on hormone-resistance mechanisms related to androgen receptor mutations or to the acquired property of prostate cancer cells to over-activate signaling pathways. Tumor microenvironment plays a critical role in prostate cancer progression. However, the mechanism involving androgen/androgen receptor signaling in cancer associated fibroblasts and consequences for prostate cancer progression still remains elusive. We now report that prostate cancer associated fibroblasts express a transcriptional-incompetent androgen receptor. Upon androgen challenging, the receptor co-localizes with the scaffold protein filamin A in the extra-nuclear compartment of fibroblasts, thus mediating their migration and invasiveness. Cancer-associated fibroblasts move towards epithelial prostate cancer cells in 2D and 3D cultures, thereby inducing an increase of the prostate cancer organoid size. Androgen enhances both these effects through androgen receptor/filamin A complex assembly in cancer-associated fibroblasts. An androgen receptor-derived stapled peptide, which disrupts the androgen receptor/filamin A complex assembly, abolishes the androgen-dependent migration and invasiveness of cancer associated fibroblasts. Notably, the peptide impairs the androgen-induced invasiveness of CAFs in 2D models and reduces the overall tumor area in androgen-treated 3D co-culture. The androgen receptor in association with β1 integrin and membrane type-matrix metalloproteinase 1 activates a protease cascade triggering extracellular matrix remodeling. The peptide also impairs the androgen activation of this cascade. This study offers a potential new marker, the androgen receptor/filamin A complex, and a new therapeutic approach targeting intracellular pathways activated by the androgen/androgen receptor axis in prostate cancer-associated fibroblasts. Such a strategy, alone or in combination with conventional therapies, may allow a more efficient treatment of prostate cancer.
Natural podophyllotoxin analog 4DPG attenuates EMT and colorectal cancer progression via activation of checkpoint kinase 2
Authors: Katoch Archana , Nayak Debasis , Faheem Mir Mohd. , Kumar Aviral , Sahu Promod Kumar , Gupta Ajai Prakash , Kumar Lekha Dinesh , Goswami Anindya 
Published: January 2021

AbstractEpithelial–mesenchymal transition (EMT) is critical for the metastatic dissemination of cancer cells and contributes to drug resistance. In this study, we observed that epithelial colorectal cancer (CRC) cells transiently exposed to 5-fluorouracil (5-FU) (a chemotherapeutic drug for CRC) as well as 5-FU-resistant cells (5-FU-R) develop EMT characters as evidenced by activation of Vimentin and augmented invasive properties. On the other hand, 4DPG (4′-demethyl-deoxypodophyllotoxin glucoside), a natural podophyllotoxin analog attenuates EMT and invadopodia formation abilities of HCT-116/5-FU-R and SW-620/5-FU-R cells. Treatment with 4DPG restrains Vimentin phosphorylation (Ser38) in 5-FU-R cells, along with downregulation of mesenchymal markers Twist1 and MMP-2 while augmenting the expression of epithelial markers E-cadherin and TIMP-1. Moreover, 4DPG boosts the tumor-suppressor protein, checkpoint kinase 2 (Chk2) via phosphorylation at Thr68 in a dose-dependent manner in 5-FU-R cells. Mechanistically, SiRNA-mediated silencing of Chk2, as well as treatment with Chk2-specific small-molecule inhibitor (PV1019), divulges that 4DPG represses Vimentin activation in a Chk2-dependent manner. Furthermore, immunoprecipitation analysis unveiled that 4DPG prevents complex formation between Vimentin and p53 resulting in the rescue of p53 and its nuclear localization in aggressive 5-FU-R cells. In addition, 4DPG confers suitable pharmacokinetic properties and strongly abrogates tumor growth, polyps formation, and lung metastasis in an orthotopic rat colorectal carcinoma model. In conclusion, our findings demonstrate 4DPG as a targeted antitumor/anti-metastatic pharmacological lead compound to circumvent EMT-associated drug resistance and suggest its clinical benefits for the treatment of aggressive cancers.