bluuebunny/crossref_metadata_2025_split huggingface dataset:
Because ‘everybody believes in different things’: Examining tolerance of divergent preferences, beliefs, and morals in kindergarten students
Authors: Danniels Erica , Perlman Michal 
Published: July 2021

AbstractSocieties are becoming increasingly pluralistic, yet acceptance of differing points of view remains an issue. Thus, it is important to understand how young children think about issues related to acceptance of differing views and factors that may be related to sharing greater levels of tolerance. A total of 167 kindergarten students (ages 4–5) were presented with pictures of hypothetical peers and told that each peer held an opposing view from them with respect to a preference (blue, blocks), belief (believing in fairies, believing in superheroes), or moral (lying, tattling). Children were asked if it was okay for this peer to hold a different view, whether they would be willing to play with the peer, and to justify their responses. Measures of children's theory of mind understanding, language ability, and prosocial behaviour were also collected. Children shared tolerant responses more frequently towards peers who held different preferences and beliefs as compared to different morals. Children who shared intolerant responses frequently rejected the peer's different view. Willingness to play with a peer was largely based on factors unrelated to tolerance such as the peer's appearance. Children with higher theory of mind understanding and older children were significantly more likely to report that it was okay for a peer to endorse a different preference or belief, but not a different moral. Implications for children's reasoning about personal versus moral norms and the promotion of tolerance in the kindergarten years are discussed.
When did the Pyrenean shortening end? Insight from U–Pb geochronology of syn‐faulting calcite (Corbières area, France)
Authors: Parizot Oriane , Missenard Yves , Haurine Frederic , Blaise Thomas , Barbarand Jocelyn , Benedicto Antonio , Sarda Philippe 
Published: July 2021

AbstractAbsolute dating helps to define the age and duration of orogen building. Here we present new U–Pb ages of syn‐faulting calcites collected in the northern foreland basin of the Pyrenees. The studied area underwent deformation during the Eocene growth of the belt. This orogenic growth is considered to have persisted until the Late Oligocene, after which post‐orogenic processes prevailed. Microstructural analysis coupled with U–Pb dating of syn‐faulting calcite confirms the well‐known NW‐SE to N–S main shortening stage of the Pyrenean orogen during the Eocene (from 48.7 ± 2.2 to 43.2 ± 5.3 Ma). But our data further reveal NE‐SW shortening during the Miocene, ca. 16 Ma ago, that has never been seen in the northern Pyrenean foreland. We propose that this tectonic phase, now identified on both sides of the Pyrenean Belt, is a consequence of a stronger coupling between Africa, Iberia and Europe at this time.
Ectopic expression of an expansin‐like B gene from wild Arachis enhances tolerance to both abiotic and biotic stresses
Authors: Brasileiro Ana C. M. , Lacorte Cristiano , Pereira Bruna M. , Oliveira Thais N. , Ferreira Deziany S. , Mota Ana P. Z. , Saraiva Mario A. P. , Araujo Ana C. G. , Silva Luciano P. , Guimaraes Patricia M. 
Published: July 2021

SummaryPlant expansins are structural cell wall‐loosening proteins implicated in several developmental processes and responses to environmental constraints and pathogen infection. To date, there is limited information about the biological function of expansins‐like B (EXLBs), one of the smallest and less‐studied subfamilies of plant expansins. In the present study, we conducted a functional analysis of the wild Arachis AdEXLB8 gene in transgenic tobacco (Nicotiana tabacum) plants to clarify its putative role in mediating defense responses to abiotic and biotic stresses. First, its cell wall localization was confirmed in plants expressing an AdEXLB8:eGFP fusion protein, while nanomechanical assays indicated cell wall reorganization and reassembly due to AdEXLB8 overexpression without compromising the phenotype. We further demonstrated that AdEXLB8 increased tolerance not only to isolated abiotic (drought) and biotic (Sclerotinia sclerotiorum and Meloidogyne incognita) stresses but also to their combination. The jasmonate and abscisic acid signaling pathways were clearly favored in transgenic plants, showing an activated antioxidative defense system. In addition to modifications in the biomechanical properties of the cell wall, we propose that AdEXLB8 overexpression interferes with phytohormone dynamics leading to a defense primed state, which culminates in plant defense responses against isolated and combined abiotic and biotic stresses.
Function of a Psychological Nursing Intervention on Depression, Anxiety, and Quality of Life in Older Adult Patients With Osteoporotic Fracture
Authors: Huang Liying , Zhang Caiting , Xu Jiahui , Wang Wei , Yu Miao , Jiang Fusong , Yan Liang , Dong Fanghui 
Published: July 2021

AbstractBackgroundOsteoporotic fracture is a serious complication of osteoporosis. The long‐term therapy process and the heavy restriction to physical activities give rise to a psychological burden on osteoporotic fracture patients, especially older adult patients. Psychological nursing interventions significantly alleviate negative emotional reactions in cancer patients. This research aimed to investigate the function of psychological nursing interventions in the reduction of depression and anxiety and the improvement of quality of life in older adult patients with osteoporotic fracture.MethodsOsteoporotic fracture patients (n = 106) were divided into control group (n = 53) or intervention group (n = 53). In the control group, the participants were given conventional nursing care. In the intervention group, the participants were given psychological nursing interventions. Anxiety, depression, and quality of life were evaluated and compared between the two groups.ResultsAfter 5 weeks of psychological nursing intervention, the anxiety and depression scores significantly decreased in the intervention group. The Mental Function in Quality of Life Questionnaire of the European Foundation for Osteoporosis score also decreased in the intervention group.Linking Evidence to ActionPsychological nursing interventions alleviate anxiety and depression in older adult osteoporotic fracture patients and enhance their mental function.
Use of a True Material Constitutive Model for Stress Analysis of a Swage Autofrettaged Tube Including ASME Code Comparison
Authors: Hu Zhong , Parker Anthony P. 
Published: July 2021

Abstract
This work reports results from a new finite element analysis (FEA)-based user programmable function (UPF) featuring true material constitutive behavior with proper algorithms for accurate stress analysis of swage autofrettage of high-strength thick-walled cylinders. This material model replicates an existing Bauschinger-effect characterization (BEC). This incorporates elastoplastic material behavior during loading. Reversed loading includes a reduced elastic modulus and nonlinear plasticity resulting from the Bauschinger effect (BE), both depending upon the maximum level of loading plastic strain. This case study identifies the difference in stress distributions based on two different material models, a bilinear kinematic hardening model, and the BEC model. Near-bore residual stresses for the BEC case are noteworthy and reported in detail, e.g., axial residual stress is tensile and hoop residual stress exhibits a distinct slope reversal, unlike hydraulic autofrettage. This indicates the possible need to re-assess the ASME pressure vessel code (correction for BE) regarding swage autofrettage.
Body image and antiretroviral therapy adherence among people living with HIV: a protocol for a systematic review and meta-analysis
Authors: Nyamaruze Patrick , Cowden Richard Gregory , Padgett R Noah , Govender Kaymarlin 
Published: July 2021

IntroductionAdherence to antiretroviral therapy (ART) remains a key challenge to achieving the fast-track goal of ending the HIV epidemic by 2030. To provide a more comprehensive indication of whether interventions designed to promote ART adherence might benefit from targeting body image perceptions, we aim to conduct a systematic review to synthesise existing evidence on the association between body image and ART adherence.Methods and analysisA systematic review of peer-reviewed observational studies and randomised controlled trials that have investigated the association between body image and adherence to ART will be performed. JSTOR, PsycARTICLES, PsycINFO, PubMed, ScienceDirect and Web of Science databases will be searched from 1 January 2000 to 31 March 2021. Eligible records will consider body image as either an independent variable or a mediator, whereas ART adherence will be assessed as an outcome variable. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and study quality will be assessed using relevant tools developed by the National Institute of Health. If sufficient data are available, a meta-analysis will be conducted. Effect size estimates will be aggregated using a random effects meta-analysis approach. Publication bias and its impact will be evaluated through the use of a funnel plot and the trim-and-fill method. The Grading of Recommendations Assessment, Development and Evaluation approach will be used to report on the overall quality of evidence.Ethics and disseminationEthical approval is not required for a systematic review protocol. Findings of the proposed systematic review will be disseminated through conference presentations and publication in a peer-reviewed journal.PROSPERO registration numberCRD42020212597.
Epidemiology of wheeze among preschool children: a population-based cross-sectional study from rural Sri Lanka
Authors: Rajapakse Mudiyanselage Shashanka Indeevara Rajapakse , Amarasiri Wadu Arachchige Dharshika Lakmali , Yasaratne Bannek Mudiyanselage Gedara Duminda , Warnasekara Janith , Agampodi Suneth 
Published: July 2021

ObjectivesTo assess the prevalence of wheeze and factors associated with its severity among 3–6 years old children.MethodologyDesignA population-based, cross-sectional study using the WHO 30 cluster methodology with probability proportionate to size sampling.Setting36 preschools registered at the divisional secretariat offices of Anuradhapura district, Sri Lanka.ParticipantsWe recruited 1060 preschool children from 36 preschools aged 3–6 years.Main outcome measurementsWe used the International Study of Asthma and Allergy in Childhood questionnaire to assess the prevalence, symptomatology and associated factors of wheeze.ResultsThe study sample consisted of 548 (51.70%) male and 512 (48.30%) female children with a mean age of 4.41 (±0.66) years. At least one wheezing episode ever was reported in 323 (30.47%; 95% CI 27.71% to 33.34%) children and 247 (23.30%; 95% CI 20.79% to 25.97%) children had a wheezing attack in the preceding year. Severe episodes of wheezing were reported in 76 (7.17%; 95% CI 5.69% to 8.89%) participants. However, only 27 (35.53%; 95% CI 24.88% to 47.34%) children with severe wheezing had been diagnosed as asthmatics by a clinician. The identified independent risk factors for severe wheeze were allergic rhinitis (OR 6.90; 95% CI 3.84 to 12.40), domestic dog(s) (OR 2.34; 95% CI 1.01 to 5.40), frequent consumption of skipjack tuna (OR 1.94; 95% CI 1.11 to 3.39) and passive smoking (OR 1.70; 95% CI 0.93 to 3.11) while living in a house with a cement floor is a protective factor (OR 0.41; 95% CI 0.21 to 0.80).ConclusionWheezing commonly affects one-fourth of preschool children in rural Sri Lanka. Severe wheezing is often not diagnosed as asthma despite frequent symptoms, probably due to hesitancy in labelling preschool children as asthmatics. Allergic rhinitis, domestic dogs, frequent consumption of Skipjack tuna fish and exposure to passive smoking were independent risk factors for severe wheeze.
Development and internal validation of a multivariable prediction model for 6-year risk of stroke: a cohort study in middle-aged and elderly Chinese population
Authors: Yu Qi , Wu Yuanzhe , Jin Qingdong , Chen Yanqing , Lin Qingying , Liu Xinru 
Published: July 2021

ObjectiveTo develop and internally validate a prediction model for 6-year risk of stroke and its primary subtypes in middle-aged and elderly Chinese population.DesignThis is a retrospective cohort study from a prospectively collected database.ParticipantsWe included a total 3124 adults aged 45–80 years, free of stroke or myocardial infarction at baseline in the 2009–2015 cohort of China Health and Nutrition Survey.Primary and secondary outcome measuresThe outcome of the prediction model was stroke. Investigated predictors were: age, gender, body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), hypertension (HBP), drinking status, smoking status, diabetes and site. Stepwise multiple Cox regression was applied to identify independent predictors. A nomogram was constructed to predict 6-year risk of stroke based on the multiple analysis results. Bootstraps with 1000 resamples were applied to both C-index and calibration curve.ResultThe overall incidence of overall stroke was 2.98%. Age, gender, HBP and TC were found as significant risk predictors for overall stroke; age, gender, HBP and LDL-C were found as significant risk predictors for ischaemic stroke; age, gender, HBP, BMI and HDL-C were found as significant risk predictors for haemorrhagic stroke. The nomogram was constructed using significant variables included in the model, with a C-index of 0.74 (95% CI: 0.72 to 0.76), 0.74 (95% CI: 0.71 to 0.77), and 0.81 (95% CI: 0.78 to 0.84) for overall stroke, ischaemic stroke, and haemorrhagic stroke model, respectively. The calibration curves demonstrated the good agreements between predicted and observed 6-year risk probability.ConclusionOur nomogram could be convenient, easy to use and effective prognoses for predicting 6-year risk of stroke in middle-aged and elderly Chinese population.
Patient-level and hospital-level variation and related time trends in COVID-19 case fatality rates during the first pandemic wave in England: multilevel modelling analysis of routine data
Authors: Bottle Alex , Faitna Puji , Aylin Paul P 
Published: July 2021

BackgroundA report suggesting large between-hospital variations in mortality after admission for COVID-19 in England attracted much media attention but used crude rates. We aimed to quantify these variations between hospitals and over time during England’s first wave (March to July 2020) and assess available patient-level and hospital-level predictors to explain those variations.MethodsWe used administrative data for England, augmented by hospital-level information. Admissions were extracted with COVID-19 codes. In-hospital death was the primary outcome. Risk-adjusted mortality ratios (standardised mortality ratios) and interhospital variation were calculated using multilevel logistic regression. Early-wave (March to April) and late-wave (May to July) periods were compared.Results74 781 admissions had a primary diagnosis of COVID-19, with 21 984 in-hospital deaths (29.4%); the 30-day total mortality rate was 28.8%. The crude in-hospital death rate fell in all ages and overall from 32.9% in March to 13.4% in July. Patient-level predictors included age, male gender, non-white ethnic group (early period only) and several comorbidities (obesity early period only). The only significant hospital-level predictor was daily COVID-19 admissions in the late period; we did not find a relation with staff absences for COVID-19, mechanical ventilation bed occupancies, total bed occupancies or bed occupancies for COVID-19 admissions in either period. Just 4 (3%) and 2 (2%) hospitals were high, and 5 (4%) and 0 hospitals were low funnel plot mortality outliers at 3 SD for early and late periods, respectively, after risk adjustment. We found no strong correlation between early and late hospital-level mortality (r=0.17, p=0.06).ConclusionsThere was modest variation in mortality following admission for COVID-19 between English hospitals after adjustment for risk and random variation, in marked contrast to early media reports. Early-period mortality did not predict late-period mortality.
Effects of infliximab on lung and circulating natural killer cells, CD56+ T cells and B cells in sarcoidosis
Authors: Kullberg Susanna , Rivera Natalia V , Grunewald Johan , Eklund Anders 
Published: July 2021

BackgroundTumour necrosis factor α (TNF-α) is pivotal in sarcoid granuloma formation, and inhibitors of TNF-α offer an attractive third-line treatment option in sarcoidosis. The sarcoid inflammation is characterised by an exaggerated T helper 1 response, and evidence indicates a contribution of dysregulated and/or deficient NK (natural killer) cells, CD56+ T cells and B cells.ObjectivesInsight into how TNF-α inhibitors influence these cells may provide more information on inflammatory mechanisms in sarcoidosis and improve understanding of such treatment. We therefore evaluated treatment effects of the TNF-α inhibitor infliximab on lung and peripheral blood (PB) NK, CD56+ T cells and B cells.MethodsFifteen patients were assessed with PB samples, spirometry and CT scan, and 11 of them also underwent bronchoalveolar lavage (BAL) close to start of infliximab treatment. These investigations were repeated after 6 months of treatment.ResultsTwelve out of 15 patients disclosed a clinical improvement at follow-up. Median percentage of BAL fluid (BALF) CD56+ T cells increased while a decrease was seen in PB (p<0.05 and 0.005, respectively). No significant changes were observed for NK cells. There was a trend towards increased median percentage of PB B cells (p=0.07), and a negative correlation was observed between PB and BALF B cells after treatment (p<0.05).ConclusionIn conclusion, 6 months of infliximab treatment in patients with sarcoidosis, of whom the majority benefited from the treatment, influenced immune cells in the lung and circulation differently, highlighting the importance of investigating several compartments concomitantly when evaluating treatment effects on the inflammatory activity.
Clinical outcomes of patients with corticosteroid refractory immune checkpoint inhibitor-induced enterocolitis treated with infliximab
Authors: Alexander James L , Ibraheim Hajir , Sheth Bhavisha , Little Jessica , Khan Muhammad Saheb , Richards Camellia , Hunter Nikki , Chauhan Dharmisha , Ratnakumaran Raguprakash , McHugh Kathleen , Pinato David J , Nathan Paul , Choy Julia , Crusz Shanthini M , Furness Andrew , Turajlic Samra , Pickering Lisa , Larkin James , Teare Julian P , Papa Sophie , Speight Ally , Sharma Anand , Powell Nick 
Published: July 2021

IntroductionImmune checkpoint inhibitors (CPIs) have changed the treatment landscape for many cancers, but also cause severe inflammatory side effects including enterocolitis. CPI-induced enterocolitis is treated empirically with corticosteroids, and infliximab (IFX) is used in corticosteroid-refractory cases. However, robust outcome data for these patients are scarce.MethodsWe conducted a multicenter (six cancer centers), cohort study of outcomes in patients treated with IFX for corticosteroid-refractory CPI-induced enterocolitis between 2007 and 2020. The primary outcome was corticosteroid-free clinical remission (CFCR) with Common Terminology Criteria for Adverse Events (CTCAE) grade 0 for diarrhea at 12 weeks after IFX initiation. We also assessed cancer outcomes at 1 year using RECIST V1.1 criteria.Results127 patients (73 male; median age 59 years) were treated with IFX for corticosteroid-refractory CPI-induced enterocolitis. Ninety-six (75.6%) patients had diarrhea CTCAE grade >2 and 115 (90.6%) required hospitalization for colitis. CFCR was 41.2% at 12 weeks and 50.9% at 26 weeks. In multivariable logistic regression, IFX-resistant enterocolitis was associated with rectal bleeding (OR 0.19; 95% CI 0.04 to 0.80; p=0.03) and absence of colonic crypt abscesses (OR 2.16; 95% CI 1.13 to 8.05; p=0.03). Cancer non-progression was significantly more common in patients with IFX-resistant enterocolitis (64.4%) as compared with patients with IFX-responsive enterocolitis (37.5%; p=0.013).ConclusionThis is the largest study to date reporting outcomes of IFX therapy in patients with corticosteroid-refractory CPI-induced enterocolitis. Using predefined robust endpoints, we have demonstrated that fewer than half of patients achieved CFCR. Our data also indicate that cancer outcomes may be better in patients developing prolonged and severe inflammatory side effects of CPI therapy.
Effect of cardiosphere-derived cells on segmental myocardial function after myocardial infarction: ALLSTAR randomised clinical trial
Authors: Ostovaneh Mohammad R , Makkar Raj R , Ambale-Venkatesh Bharath , Ascheim Deborah , Chakravarty Tarun , Henry Timothy D , Kowalchuk Glen , Aguirre Frank V , Kereiakes Dean J , Povsic Thomas J , Schatz Richard , Traverse Jay H , Pogoda Janice , Smith Rachel D , Marbán Linda , Marbán Eduardo , Lima Joao A C 
Published: July 2021

BackgroundMost cell therapy trials failed to show an improvement in global left ventricular (LV) function measures after myocardial infarction (MI). Myocardial segments are heterogeneously impacted by MI. Global LV function indices are not able to detect the small treatment effects on segmental myocardial function which may have prognostic implications for cardiac events. We aimed to test the efficacy of allogeneic cardiosphere-derived cells (CDCs) for improving regional myocardial function and contractility.MethodsIn this exploratory analysis of a randomised clinical trial, 142 patients with post-MI with LVEF <45% and 15% or greater LV scar size were randomised in 2:1 ratio to receive intracoronary infusion of allogenic CDCs or placebo, respectively. Change in segmental myocardial circumferential strain (Ecc) by MRI from baseline to 6 months was compared between CDCs and placebo groups.ResultsIn total, 124 patients completed the 6-month follow-up (mean (SD) age 54.3 (10.8) and 108 (87.1%) men). Segmental Ecc improvement was significantly greater in patients receiving CDC (−0.5% (4.0)) compared with placebo (0.2% (3.7), p=0.05). The greatest benefit for improvement in segmental Ecc was observed in segments containing scar tissue (change in segmental Ecc of −0.7% (3.5) in patients receiving CDC vs 0.04% (3.7) in the placebo group, p=0.04).ConclusionsIn patients with post-MI LV dysfunction, CDC administration resulted in improved segmental myocardial function. Our findings highlight the importance of segmental myocardial function indices as an endpoint in future clinical trials of patients with post-MI.Trial registration numberNCT01458405.
Tidal effects in 4D Einstein–Gauss–Bonnet black hole spacetime
Authors: Li Jing , Chen Songbai , Jing Jiliang 
Published: July 2021

AbstractWe have investigated tidal forces and geodesic deviation motion in the 4D-Einstein–Gauss–Bonnet spacetime. Our results show that tidal force and geodesic deviation motion depend sharply on the sign of Gauss–Bonnet coupling constant. Comparing with Schwarzschild spacetime, the strength of tidal force becomes stronger for the negative Gauss–Bonnet coupling constant, but is weaker for the positive one. Moreover, tidal force behaves like those in the Schwarzschild spacetime as the coupling constant is negative, and like those in Reissner–Nordström black hole as the constant is positive. We also present the change of geodesic deviation vector with Gauss–Bonnet coupling constant under two kinds of initial conditions.