bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Rhythmic Breathing on the Severity of Sternotomy Pain after Coronary Artery Bypass Graft Surgery: A Randomized Controlled Clinical Trial
Authors: Babamohamadi Hassan , Karkeabadi Masoumeh , Ebrahimian Abbasali 
Published: June 2021

Background. Moderate-to-severe pain is reported in up to 75% of the patients in the first 48 hours after cardiac surgery. Evidence suggests that distraction is an effective nursing intervention for controlling short-term and transient pain. Distraction can be achieved by various techniques, including progressive muscle relaxation, meditation, and rhythmic breathing (RB). The present research aimed at evaluating the impacts of RB on the severity of sternotomy pain after Coronary Artery Bypass Graft (CABG). Methods. This randomized, controlled clinical trial was conducted on 60 patients after CABG surgery at the open-heart surgery Intensive Care Unit (ICU) of Kowsar Hospital, affiliated to Semnan University of Medical Sciences in Semnan, Iran. The patients were selected through convenience sampling and randomly assigned to two groups, including (1) intervention or RB and (2) control groups. RB was performed in the intervention group every 12 hours (9 a.m. and 9 p.m.) for three consecutive days after the surgery. The control group received only routine care for pain control (opioid analgesics) with no additional interventions. The severity of pain was measured every day in both groups of patients before and after the interventions using the Visual Analog Scale (VAS). Results. The mean postintervention pain scores were significantly different from the mean preintervention scores in the intervention group (

p

< 0.05). The changes in the mean pain score in the intervention group were also significantly different from the corresponding changes in the controls (

p

< 0.05). Conclusion. Based on the results, the severity of pain after the intervention was significantly lower in the RB group compared to the control. RB was found to be an effective technique for reducing the patients’ pain and is therefore recommended as a post-CABG pain control technique. Iranian Registry of Clinical Trials: this trial is clinically registered with IRCT20120109008665N7, registered 3 September 2018.
СУЧАСНЕ СТАВЛЕННЯ ДО УЧАСТІ МЕДИЧНИХ СЕСТЕР У ВИРІШЕННІ ПРОБЛЕМИ ЛІКУВАННЯ ПОСТРАЖДАЛИХ ВІД НАСЛІДКІВ АВАРІЇ НА ЧОРНОБИЛЬСЬКІЙ АТОМНІЙ ЕЛЕКТРОСТАНЦІЇ ТА МЕТОДОЛОГІЇ ДІАГНОСТИКИ ТА ЛІКУВАННЯ БОЛЮ У ЦІЄЇ КАТЕГОРІЇ ХВОРИХ
Authors: SHEVCHENKO O. 
Published: June 2021

Міжнародна асоціація з вивчення болю (IASP) дає йому таке визначення: це неприємне сенсорне і емоційне переживання, пов'язане з дійсним або потенційним пошкодженням тканини. Біль є однією з найпоширеніших скарг, проте являє собою феномен, найбільш важкий для уточнення. Тривалий час він розглядався виключно як проблема лікаря і пацієнта, проте протягом останнього часу у боротьбі з ним значне місце стали займати медичні сестри. Для досягнення позитивного ефекту у цьому необхідно користуватись обґрунтованими стандартами та схемами діагностики і лікування.
O papel dos cronistas brasileiros na transformação da imagem da capoeira no início do século XX (1900-1930)
Authors: Aquino Pedro Gabriel Neves de 
Published: June 2021

O objetivo deste artigo é analisar como os cronistas brasileiros do início do século XX constroem uma nova imagem sobre a capoeira para a sociedade brasileira entre os anos 1900 e 1930, valorizando-a enquanto esporte em contraposição à imagem negativa que existia previamente sobre a prática, marcada por ideias do racismo científico. Buscando compreender isso, será realizada a análise de crônicas, artigos e guias esportivos produzidos por intelectuais do período, visando expor os argumentos destes intelectuais que buscaram a valorização da capoeira, expondo as transformações que ocorreram no pensamento social brasileiro sobre a prática da capoeira no período, perpassando questões como a manifestação ou apagamento da herança africana da capoeira.
Além disso, a análise busca entender como a capoeira se insere e quais debates apareceram ligados a ela na construção da nacionalidade republicana brasileira em uma sociedade pós-abolição da escravidão marcada por teorias de superioridade racial e as principais disputas argumentativas nesse meio intelectual. Essa construção da imagem da capoeira com valor e destaque na sociedade teve grande influência na formação das primeiras academias formais de capoeira (1932), a descriminalização da prática (1940, oficialmente), sua subsequente transformação em prática esportiva nacional do Brasil (1941) e posterior difusão pelo mundo, marcando fortemente o entendimento de nacionalidade do povo brasileiro. Assim, entender a forma como os círculos letrados do Brasil reconstroem a imagem da capoeira é buscar compreender uma parte da formação da nacionalidade do Brasil.
A Quarta Cruzada e a identidade cristã: a abordagem pós-colonial de George E. Demacopoulos.
Authors: Vicente Rodrigo Fernandes 
Published: June 2021

A presente resenha aborda a obra Colonizing Christianity. Greek and Latin Religious Identity in the Era of the Fourth Crusade de Geroge E. Demacopoulos e a sua abordagem pós-colonial.
Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice
Authors: Shen Yuntian , Li Ran , Yu Shu , Zhao Qiang , Wang Zhuoran , Sheng Huaxin , Yang Wei 
Published: June 2021

BackgroundIschemia/reperfusion injury impairs proteostasis, and triggers adaptive cellular responses, such as the unfolded protein response (UPR), which functions to restore endoplasmic reticulum homeostasis. After cardiac arrest (CA) and resuscitation, the UPR is activated in various organs including the brain. However, the role of the UPR in CA has remained largely unknown. Here we aimed to investigate effects of activation of the ATF6 (activating transcription factor 6) UPR branch in CA.Methods and ResultsConditional and inducible sATF6‐KI (short‐form ATF6 knock‐in) mice and a selective ATF6 pathway activator 147 were used. CA was induced in mice by KCl injection, followed by cardiopulmonary resuscitation. We first found that neurologic function was significantly improved, and neuronal damage was mitigated after the ATF6 pathway was activated in neurons of sATF6‐KI mice subjected to CA/cardiopulmonary resuscitation. Further RNA sequencing analysis indicated that such beneficial effects were likely attributable to increased expression of pro‐proteostatic genes regulated by ATF6. Especially, key components of the endoplasmic reticulum–associated degradation process, which clears potentially toxic unfolded/misfolded proteins in the endoplasmic reticulum, were upregulated in the sATF6‐KI brain. Accordingly, the CA‐induced increase in K48‐linked polyubiquitin in the brain was higher in sATF6‐KI mice relative to control mice. Finally, CA outcome, including the survival rate, was significantly improved in mice treated with compound 147.ConclusionsThis is the first experimental study to determine the role of the ATF6 UPR branch in CA outcome. Our data indicate that the ATF6 UPR branch is a prosurvival pathway and may be considered as a therapeutic target for CA.
Genome analysis to decipher syntrophy in the bacterial consortium ‘SCP’ for azo dye degradation
Authors: Nanjani Sandhya , Paul Dhiraj , Keharia Hareshkumar 
Published: June 2021

Abstract
Background
A bacterial consortium SCP comprising three bacterial members, viz. Stenotrophomonas acidaminiphila APG1, Pseudomonas stutzeri APG2 and Cellulomonas sp. APG4 was developed for degradation of the mono-azo dye, Reactive Blue 28. The genomic analysis of each member of the SCP consortium was done to elucidate the catabolic potential and role of the individual organism in dye degradation.

Results
The genes for glycerol utilization were detected in the genomes of APG2 and APG4, which corroborated with their ability to grow on a minimal medium containing glycerol as the sole co-substrate. The genes for azoreductase were identified in the genomes of APG2 and APG4, while no such trait could be determined in APG1. In addition to co-substrate oxidation and dye reduction, several other cellular functions like chemotaxis, signal transduction, stress-tolerance, repair mechanisms, aromatic degradation, and copper tolerance associated with dye degradation were also annotated. A model for azo dye degradation is postulated, representing the predominant role of APG4 and APG2 in dye metabolism while suggesting an accessory role of APG1.

Conclusions
This exploratory study is the first-ever attempt to divulge the genetic basis of azo-dye co-metabolism by cross-genome comparisons and can be harnessed as an example for demonstrating microbial syntrophy.
Decreasing leakage during continuous femoral nerve catheter fixation using 2-octyl cyanoacrylate glue (Dermabond®): a randomized controlled trial
Authors: Chalacheewa Theerawat , Arnuntasupakul Vanlapa , Sangkum Lisa , Buachai Rungrawan , Chanvitayapongs Jiravud 
Published: June 2021

AbstractBackgroundContinuous peripheral nerve catheters (CPNCs) have been used for postoperative pain relief. A common problem encountered with CPNCs is pericatheter leakage, which can lead to dressing adhesive failure. Frequent dressing changes increase the risk of catheter dislodgement and infections. Adhesive glue is effective in securing the peripheral nerve catheter and decreasing leakage around the catheter insertion site. This study aimed to evaluate the incidence of pericatheter leakage with fixation using 2-octyl cyanoacrylate glue (Dermabond®) as compared to sterile strips.MethodsThirty patients undergoing unilateral total knee arthroplasty (TKA) with continuous femoral nerve catheter for postoperative analgesia were randomized into the catheter fixation with 2-octyl cyanoacrylate glue (Dermabond®) group or the sterile strip group. The primary outcome was the incidence of pericatheter leakage. Secondary outcomes included the frequent of catheter displacement, the difficulty of catheter removal, pain score and patient satisfaction.ResultsThe incidence of pericatheter leakage at 24 and 48 h was 0% versus 93 and 0% versus 100% in the Dermabond®and sterile strip groups, respectively (P < 0.001). The incidence of displacement at 24 and 48 h was 6.7% versus 93.3 and 6.7% versus 100% in the Dermabond® and sterile strip, respectively (P < 0.001). There was no difference in numeric rating scale, difficulty of catheter removal, or satisfaction scores between groups.ConclusionsCatheter fixation with 2-octyl cyanoacrylate glue (Dermabond®) decreased the incidence of pericatheter leakage, as well as catheter displacement, over 48 h as compared to sterile strip fixation.Trial registrationThis trial was registered on Thai clinical trial registry:TCTR20200228002, registered 24 February 2020- Retrospectively registered.
Five metastasis-related mRNAs signature predicting the survival of patients with liver hepatocellular carcinoma
Authors: Chen Chao , Liu Yan Qun , Qiu Shi Xiang , Li Ya , Yu Ning Jun , Liu Kang , Zhong Li Ming 
Published: June 2021

Abstract
Backgrounds
Liver hepatocellular carcinoma (HCC) is one of the most malignant tumors, of which prognosis is unsatisfactory in most cases and metastatic of HCC often results in poor prognosis. In this study, we aimed to construct a metastasis- related mRNAs prognostic model to increase the accuracy of prediction of HCC prognosis.

Methods
Three hundred seventy-four HCC samples and 50 normal samples were downloaded from The Cancer Genome Atlas (TCGA) database, involving transcriptomic and clinical data. Metastatic-related genes were acquired from HCMBD website at the same time. Two hundred thirty-three samples were randomly divided into train dataset and test dataset with a proportion of 1:1 by using caret package in R. Kaplan-Meier method and univariate Cox regression analysis and lasso regression analysis were performed to obtain metastasis-related mRNAs which played significant roles in prognosis. Then, using multivariate Cox regression analysis, a prognostic prediction model was established. Transcriptome and clinical data were combined to construct a prognostic model and a nomogram for OS evaluation. Functional enrichment in high- and low-risk groups were also analyzed by GSEA. An entire set based on The International Cancer Genome Consortium(ICGC) database was also applied to verify the model. The expression levels of SLC2A1, CDCA8, ATG10 and HOXD9 are higher in tumor samples and lower in normal tissue samples. The expression of TPM1 in clinical sample tissues is just the opposite.

Results
One thousand eight hundred ninety-five metastasis-related mRNAs were screened and 6 mRNAs were associated with prognosis. The overall survival (OS)-related prognostic model based on 5 MRGs (TPM1,SLC2A1, CDCA8, ATG10 and HOXD9) was significantly stratified HCC patients into high- and low-risk groups. The AUC values of the 5-gene prognostic signature at 1 year, 2 years, and 3 years were 0.786,0.786 and 0.777. A risk score based on the signature was a significantly independent prognostic factor (HR = 1.434; 95%CI = 1.275–1.612; P < 0.001) for HCC patients. A nomogram which incorporated the 5-gene signature and clinical features was also built for prognostic prediction. GSEA results that low- and high-risk group had an obviously difference in part of pathways. The value of this model was validated in test dataset and ICGC database.

Conclusion
Metastasis-related mRNAs prognostic model was verified that it had a predictable value on the prognosis of HCC, which could be helpful for gene targeted therapy.
Hybrid ileal pouch with concomitant anti-refluxing and refluxing ureteroileal anastomosis
Authors: Choi Se Young , Lim Bumjin , Chi Byung Hoon , Kim Jung Hoon , Lee Wonchul , You Dalsan , Kim Choung-Soo 
Published: June 2021

Abstract
Purpose
We report our preliminary experience of using a hybrid ileal pouch, assessing oncologic outcomes, complications, voiding, and renal function.

Methods
The study included 25 patients with bladder cancer treated with radical cystectomy with a hybrid ileal pouch with concomitant anti-refluxing and refluxing anastomosis, performed by a single surgeon. The patients were divided into two groups (first and last cases) according to the surgery date. Postoperative complications, separate renal function by renal scan, voiding function by uroflowmetry with residual urine, and oncologic outcomes were assessed.

Results
The surgery duration was shorter in the last cases than the first cases. The voiding volume increased with time. There were 23 cases of grade 3 complication in 12 patients and one case of grade 4 complication (sepsis). In the first cases, ureterovesical stenosis occurred in five cases, whereas in the last cases, there were no cases of stenosis. In separate renal function, there was no difference between the left and right side or between the first and last cases.

Conclusions
The hybrid ileal pouch showed acceptable oncologic and functional outcomes and complications; therefore, it can be used according to the appropriate surgical situation with a relatively short bowel segment during neobladder construction.
Inflammatory signaling mechanisms in bipolar disorder
Authors: Jones Gregory H. , Vecera Courtney M. , Pinjari Omar F. , Machado-Vieira Rodrigo 
Published: June 2021

AbstractBipolar disorder is a decidedly heterogeneous and multifactorial disease, with a high individual and societal burden. While not all patients display overt markers of elevated inflammation, significant evidence suggests that aberrant immune signaling contributes to all stages of the disease, and likely explains the elevated rates of comorbid inflammatory illnesses seen in this population. While individual systems have been intensely studied and targeted, a relative paucity of attention has been given to the interconnecting role of inflammatory signals therein. This review presents an updated overview of some of the most prominent pathophysiologic mechanisms in bipolar disorder, from mitochondrial, endoplasmic reticular, and calcium homeostasis, to purinergic, kynurenic, and hormonal/neurotransmitter signaling, showing inflammation to act as a powerful nexus between these systems. Several areas with a high degree of mechanistic convergence within this paradigm are highlighted to present promising future targets for therapeutic development and screening.
Downregulation of decidual SKP2 is associated with human recurrent miscarriage
Authors: Lv Shijian , Liu Mei , Xu Lizhen , Zhang Cong 
Published: June 2021

Abstract
Background
Recurrent miscarriage (RM) is a very frustrating problem for both couples and clinicians. To date, the etiology of RM remains poorly understood. Decidualization plays a critical role in implantation and the maintenance of pregnancy, and its deficiency is closely correlated with RM. The F-box protein S-phase kinase associated protein 2 (SKP2) is a key component of the SCF-type E3 ubiquitin ligase complex, which is critically involved in ErbB family-induced Akt ubiquitination, aerobic glycolysis and tumorigenesis. SKP2 is pivotal for reproduction, and SKP2-deficient mice show impaired ovarian development and reduced fertility.

Methods
Here, we investigated the expression and function of SKP2 in human decidualization and its relation with RM. A total of 40 decidual samples were collected. Quantitative PCR analysis, western blot analysis and immunohistochemistry analysis were performed to analyze the differential expression of SKP2 between RM and control cells. For in vitro induction of decidualization, both HESCs (human endometrial stromal cells) cell line and primary ESCs (endometrial stromal cells) were used to analyze the effects of SKP2 on decidualization via siRNA transfection.

Results
Compared to normal pregnant women, the expression of SKP2 was reduced in the decidual tissues from individuals with RM. After in vitro induction of decidualization, knockdown of SKP2 apparently attenuated the decidualization of HESCs and resulted in the downregulation of HOXA10 and FOXM1, which are essential for normal human decidualization. Moreover, our experiments demonstrated that SKP2 silencing reduced the expression of its downstream target GLUT1.

Conclusions
Our study indicates a functional role of SKP2 in RM: downregulation of SKP2 in RM leads to impaired decidualization and downregulation of GLUT1 and consequently predisposes individuals to RM.
Trophectoderm biopsy of blastocysts for a preimplantation genetic test does not affect serum β-hCG levels in early pregnancy: a study using propensity score matching
Authors: Wu Yixuan , Ying Ying , Cao Mingzhu , Liu Jianqiao , Liu Haiying 
Published: June 2021

Abstract
Background
Although preimplantation genetic test (PGT) has been used worldwide, few studies investigated the effect of trophectoderm biopsy of blastocysts on early embryo development. This study aimed to investigate whether trophectoderm (TE) biopsy of blastocysts for a PGT affected serum β-human chorionic gonadotropin (hCG) levels 14 days after transfer.

Methods
This was a retrospective cohort study conducted at the Third Affiliated Hospital of Guangzhou Medical University. The study population comprised pregnant women undergoing the transfer of single vitrified-warmed blastocysts after PGT between January 1, 2018, and July 30, 2020. The control group had non-PGT cycles with other inclusion criteria identical to those for the study group. Propensity score matching was used to screen a group of patients so that the baseline characteristics were similar between the two groups. Serum β-hCG levels were compared between the PGT and non-PGT cycles. Multiple linear regression was used to analyze the influence of PGT on serum β-hCG levels, while receiver operating characteristic curves (ROC curves) were plotted to predict pregnancy outcomes using serum β-hCG levels.

Results
Serum β-hCG levels were comparable between the PGT and non-PGT patients: live birth: 2503 ± 1702 mIU/mL vs 2266 ± 1289 mIU/mL (P = 0.219); clinical pregnancy: 2261 ± 1564 mIU/mL vs 2148 ± 1348 mIU/mL (P = 0.461); and ongoing pregnancy: 2412 ± 1589 mIU/mL vs 2278 ± 1308 mIU/mL (P = 0.422). Multiple linear regression analysis indicated no impact of PGT on the serum β-hCG level (standardized coefficient = − 0.001, P = 0.989). For clinical pregnancy, the cutoff value was 482 mIU/mL and 302 mIU/mL for PGT and non-PGT patients, respectively. The threshold to predict live birth was 1345 mIU/mL and 1621 mIU/mL in the PGT and non-PGT cycles, respectively.

Conclusion
Trophectoderm biopsy of blastocysts for PGT did not affect the serum β-hCG level 14 days after transfer.
Reading in the Age of Compression
Authors: Koepnick Lutz 
Published: June 2021

Abstract
Compression is often considered a royal road to process data in ever-shorter time and to cater to our desire to outspeed the accelerating transmission of information in the digital age. This article explores how different techniques of accelerated text dissemination and reading, such as consonant writing, speed-reading apps, and the PDF file format, borrow from the language of compression yet, precisely in so doing, obscure the constitutive multilayered temporality of reading and the embodied role of the reader. While discussing different methods aspiring to compress textual objects and processes of reading, the author illuminates hidden assumptions that accompany the rhetoric of text compression and compressed reading.
Reading Times: Temporalities and Time Work in Current Everyday Reading Practices
Authors: Dalsgård Anne Line 
Published: June 2021

AbstractInspired by Pierre Bourdieu's observation that practice is not in time but makes time and Michael Flaherty's concept of time work, this article explores temporal aspects of the use of literature in contemporary Denmark and describes how reading allows readers to manipulate their experience of time. The main part of the article focuses on cultural norms and readers’ expectations in relation to reading time, while the last, shorter part discusses the structuring temporal effects of a literary text, such as presence, narrative, and endings. The article concludes that time is not just a practical issue to consider (when and where to read), or just something to work on through reading (e.g., changing a boring time into flow time). Texts also affect the readers’ sense of time; that is, agency lies in the literature read as well as the reader. The empirical data are drawn from extensive ethnographic fieldwork (mainly qualitative interviews) in different social and geographical contexts in Denmark from 2014 to 2019. The article contributes to empirical reading studies by exploring everyday reading as a practice in and of time.
What Is Just Translation?
Authors: Apter Emily 
Published: June 2021

Abstract
This article summarizes a broader project on “just translation” that attempts to rethink translation in the framework of Western philosophies of right, Sittlichkeit (ethical norms, customs, practices), and theories of justice (Plato, Hegel, Rawls), as well as of recent work on “postcolonial justice” that negotiates the collision between the drive toward universality and the normative, on the one hand, and the drive toward difference, on the other. Devising a critical approach that “does justice” to the nuances of words associated with adjudication in all the world's languages is the larger aspiration. But given practical limitations, this means scaling down to select terms and cases that signal translational injustice under conditions of violence and legal disputation. These conditions include gender violence and sexual safety across languages, the untranslatability of terms like refugee and migrant, the fraught vocabulary of settlement and unsettlement (involving the translation of terms like indigeneity, occupation, detention zone, and camp), shibboleth tests and the foreclosure of the right to residency (which amounts to the passporting of speech), and the multilingual scripts of biopolitical surveillance and patrol relied on in forcible-entry raids, stop and frisk, and executions of orders to “report and deport.”