bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients’ perceptions of orthodontic treatment experiences during COVID-19: a cross-sectional study
Authors: Arqub Sarah Abu , Voldman Rebecca , Ahmida Ahmad , Kuo Chia-Ling , Godoy Lucas Da Cunha , Nasrawi Yousef , Al-Khateeb Susan N. , Uribe Flavio 
Published: June 2021

Abstract
Background
COVID-19 has impacted the care of patients undergoing orthodontic treatment. We aimed to provide an overall view of patients’ perspectives, concerns, and expectations towards their treatment throughout the clinic lockdown during the pandemic; and to assess patients’ levels of mental distress and its association with their confidence in resuming care.

Methods
An anonymous, validated, in-person paper questionnaire was distributed to adult orthodontic patients’ post-lockdown at an academic institution. The survey focused on the clinical aspects and patients’ perspectives regarding orthodontic treatment during the pandemic. The Kessler Mental Distress Scale (K10) was used to evaluate their psychological status. Survey responses were descriptively summarized and confidence in resuming care was compared between normal patients and patients with mental distress using Mann-Whitney tests.

Results
One hundred fifty-four patients were surveyed from July to October 2020. Mean age of the participants was 29.30 (SD = 12.01) years and 62% were females. Emergencies during the closure (21%, 32/154) involved primarily irritation with protruding wires. Patients were neutral regarding tele-dentistry and preferred their current fixed appliances over clear aligners. Upon resuming care, 80.51% were extremely pleased with the restrictive protocols and with high level of confidence in resuming treatment. The average level of anxiety was low, and a modest association was found between mental distress and reduced confidence in resuming treatment.

Conclusions
Few numbers of minor emergencies occurred during the clinic closure. Despite the rising interest in tele-dentistry, patients were neutral on considering this option to monitor treatment and were content with fixed appliances. Patients had high confidence levels to resume their care based on the protocols established upon reopening. The association of mental distress and confidence in resuming care is suggestive and needs further investigation.
The association between adherence to a dietary approaches to stop hypertension (DASH) diet and neuro-psychological function in young women
Authors: Saharkhiz Mansoore , Khorasanchi Zahra , Karbasi Samira , Jafari-Nozad Amir Masoud , Naseri Mohsen , Mohammadifard Mahtab , Siami Ali Abad Mahin , Ayadilord Malaksima , Ferns Gordon A. , Bahrami Afsane 
Published: June 2021

Abstract
Background
The adherence to a Dietary Approaches to Stop Hypertension (DASH) diet may have a bidirectional relationship with mental wellbeing. We aimed to evaluate the association between compliance with a DASH diet and neuro-psychological function in young women.

Methods
In this cross-sectional study, a total of 181 girls aged between 18 and 25 years were recruited. The dietary intakes of study participants were evaluated using a valid and reliable food frequency questionnaire (FFQ) containing 65 food items. Neuropsychological function of participants was evaluated using standard questionnaires.

Results
As may be expected, individuals in the highest tertile (T3) of adherence to DASH diet (highest adherence) were found to consume more folate, fruits, vegetables, low fat dairy, nuts, legume, and seed, less sweetened beverage and sodium, compared to the participants in the lowest tertile (T1, lowest adherence). There was a significant negative correlation between cognitive function and consumption of red and processed meat (r = − 0.168; p < 0.05); quality of life score with dietary sodium (r = − 0.151; p < 0.01) and depression score with dietary vegetables (r = − 0.174; p < 0.05). In multivariate multinomial logistic regression analyses adjusted for age, BMI and energy intake, adherence to a DASH-style diet was associated with a lower stress score (OR = 0.70; 95%CI: 0.34–1.47, P = 0.067; T3 vs. T1) and difficulty with sleep initiation (OR = 0.46; 95%CI: 0.21–1.00, P = 0.017; T3 vs. T1).

Conclusion
Adherence to a DASH diet may be associated with reduced stress and difficulty with initiating sleep.
Endovascular balloon-assisted liquid embolisation of soft tissue vascular malformations: technical feasibility and safety
Authors: Lamanna Anthony , Maingard Julian , Florescu Grace , Kok Hong Kuan , Ranatunga Dinesh , Barras Christen , Lee Michael J. , Brooks Duncan Mark , Jhamb Ashu , Chandra Ronil V. , Asadi Hamed 
Published: June 2021

Abstract
Purpose
Arteriovenous malformations (AVMs) are abnormal communications between arteries and veins without an intervening capillary system. The best endovascular treatment option for these is unclear and may involve multiple staged procedures using a variety of embolic materials. We report our initial experience using a modified version of a previously published neurointerventional technique to treat soft tissue AVMs with single-stage curative intent.

Materials and methods
Soft tissue AVMs treated endovascularly using either sole arterial or combined arterial and venous balloon-assisted techniques with liquid embolic agents were retrospectively identified over a 3.5 year period (January 2017 to June 2020)) at two centres. Clinical, pre-operative radiological, procedural technical and post treatment details were recorded.

Results
Seven patients were treated for symptomatic soft tissue arteriovenous malformations. These AVMs were located in the peripheral limbs (five), tongue (one) and uterus (one). Curative treatment was achieved in 6/7 patients with one patient requiring a second treatment approximately 1 year later. A variety of liquid embolisation agents (LEAs) including sclerosants and polymers were used. Clinical success rate was 100% following treatment. One patient experienced expected temporary post-operative tongue swelling requiring tracheostomy occurred following embolisation of the lingual AVM. A minor complication in a second patient was due to an access site haematoma developed following treatment of the hand AVM requiring surgical intervention. No long-term sequelae or additional complications were observed.

Conclusion
Endovascular arterial and venous balloon assisted LEA embolization of soft tissue AVMs with curative intent is feasible. This technique may provide an alternative treatment option for achieving durable occlusion for complex soft tissue AVMs.
Hormonal contraceptive use and depressive symptoms: systematic review and network meta-analysis of randomised trials
Authors: de Wit Anouk E. , de Vries Ymkje Anna , de Boer Marrit K. , Scheper Celeste , Fokkema Ante A. , Schoevers Robert A. , Giltay Erik J. 
Published: June 2021

BackgroundObservational studies suggest that hormonal contraceptive use may increase depressive symptoms in women, but it is unclear whether the effect is causal.AimsTo quantitatively examine the evidence from randomised clinical trials for the link between hormonal contraceptive use and depressive symptoms.MethodWe performed a systematic review and network meta-analysis of randomised clinical trials comparing women randomised to any form of a hormonal contraceptive with women randomised to any other form of a (non-)hormonal contraceptive or placebo. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Web of Science, PsycINFO, EMCare and EMBASE, from inception to 1 May 2020. Certainty of the evidence was assessed with the Grading of Recommendations Assessment, Development and Evaluation approach. A random-effect Bayesian network meta-analysis was conducted, with change in depressive symptoms between baseline and three cycles as outcome.ResultsThis review identified 3492 records, of which 14 trials were eligible and 12 could be included in the network meta-analysis. These trials included 5833 participants (mean age per study range: 16.8–32.4 years) and compared 10 different interventions. Compared with placebo, hormonal contraceptive use did not cause worsening of depressive symptoms (standardised mean difference: median, −0.04; range, −0.17 [95% credible interval −0.46 to 0.13] to 0.13 [95% credible interval −0.28 to 0.56]).ConclusionsThis study suggests that hormonal contraceptive use does not lead to an increase in depressive symptoms in adult women. Future studies should include first-time users, to confirm the results in young women.
Use of Continuous Glucose Monitor in Critically Ill COVID-19 Patients Requiring Insulin Infusion: An Observational Study
Authors: Faulds Eileen R , Boutsicaris Andrew , Sumner Lyndsey , Jones Laureen , McNett Molly , Smetana Keaton S , May Casey C , Buschur Elizabeth , Exline Matthew C , Ringel Matthew D , Dungan Kathleen 
Published: June 2021

AbstractContextThe coronavirus disease 2019 (COVID-19) pandemic has created a need for remote blood glucose (BG) monitoring in the intensive care unit (ICU).ObjectiveTo evaluate feasibility and patient safety of a hybrid monitoring strategy of point-of-care (POC) BG plus continuous glucose monitor (CGM) in the ICU.DesignRetrospective analysis.SettingICU of an academic medical center.PatientsPatients with COVID-19 on IV insulin.InterventionAfter meeting initial validation criteria, CGM was used for IV insulin titration and POC BG was performed every 6 hours or as needed.Main Outcome MeasuresOutcomes included frequency of POC BG, workflow, safety, and accuracy measures.ResultsThe study included 19 patients, 18 with CGM data, mean age 58 years, 89% on mechanical ventilation, 37% on vasopressors, and 42% on dialysis. The median time to CGM validation was 137 minutes (interquartile range [IQR] 114-206). During IV insulin, the median number of POC values was 7 (IQR 6-16) on day 1, and declined slightly thereafter (71% reduction compared with standard of 24/day). The median number of CGM values used nonadjunctively to titrate IV insulin was 11.5 (IQR 0, 15) on day 1 and increased thereafter. Time in range 70 to 180 mg/dL was 64 ± 23% on day 1 and 72 ± 16% on days 2 through 7, whereas time &lt;70 mg/dL was 1.5 ± 4.1% on day 1 and &lt;1% on days 2 through 7.ConclusionsThis study provides data to support that CGM using a hybrid protocol is feasible, accurate, safe, and has potential to reduce nursing and staff workload.
RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first–second trimester transition
Authors: Prater Malwina , Hamilton Russell S. , Wa Yung Hong , Sharkey Andrew M. , Robson Paul , Abd Hamid N. Erlyani , Jauniaux Eric , Charnock-Jones D. Stephen , Burton Graham J. , Cindrova-Davies Tereza 
Published: June 2021

ABSTRACT
The human placenta is exposed to major environmental changes towards the end of the first trimester associated with full onset of the maternal arterial placental circulation. Changes include a switch from histotrophic to hemotrophic nutrition, and a threefold rise in the intraplacental oxygen concentration. We evaluated their impact on trophoblast development and function using RNA-sequencing (RNA-Seq) and DNA-methylation analyses performed on the same chorionic villous samples at 7–8 (n=8) and 13–14 (n=6) weeks of gestation. Reads were adjusted for fetal sex. Most DEGs were associated with protein processing in the endoplasmic reticulum (ER), hormone secretion, transport, extracellular matrix, vasculogenesis, and reactive oxygen species metabolism. Transcripts higher in the first trimester were associated with synthesis and ER processing of peptide hormones, and glycolytic pathways. Transcripts encoding proteins mediating transport of oxygen, lipids, protein, glucose, and ions were significantly increased in the second trimester. The motifs of CBX3 and BCL6 were significantly overrepresented, indicating the involvement of these transcription factor networks in the regulation of trophoblast migration, proliferation and fusion. These findings are consistent with a high level of cell proliferation and hormone secretion by the early placenta to secure implantation in a physiological low-oxygen environment.
Developmental and adult acclimation impact cold and drought survival of invasive tropicalDrosophila kikkawai
Authors: Parkash Ravi , Lambhod Chanderkala , Pathak Ankita 
Published: June 2021

ABSTRACTNarrow distribution patterns of tropical Drosophila species are limited by lower resistance to cold or drought. In the invasive tropical Drosophila kikkawai, we tested whether developmental and adult acclimations at cooler temperatures could enhance its stress resistance level. Adult acclimation of winter collected body color morphs revealed a significant increase in the level of cold resistance. For light morph, its abundance during winter is not consistent with thermal-melanism hypothesis. However, higher cold acclimation capacity, as well as storage of energy metabolites could support its winter survival. In the wild-caught light and intermediate morphs, there is a lack of trade-off between cold and heat resistance but not in the case of dark morph. Developmental plasticity (15°C) resulted in the fivefold increase of cold survival at 0°C; and a twofold increase in desiccation resistance but a modest reduction (∼28–35%) in heat resistance as compared to morph strains reared at 25°C. Drought acclimation changes were significantly higher as compared with cold or heat pretreatment. We observed a trade-off between basal resistance and acclimation capacity for cold, heat, or drought resistance. For homeostatic energy balance, adult acclimation responses (cold versus drought; heat versus drought) caused compensatory plastic changes in the levels of proline or trehalose (shared patterns) but different patterns for total body lipids. In contrast, rapid cold or heat hardening-induced changes in energy metabolites were different as compared to acclimation. The ability of D. kikkawai to significantly increase stress tolerance through plasticity is likely to support its invasion potential.
Deep Gluteal Syndrome: A Pain in the Buttock
Authors: Hu Yao-Wen Eliot , Ho Garry W.K. , Tortland Paul D. 
Published: June 2021

Abstract
While buttock pain is a common complaint in sports medicine, deep gluteal syndrome (DGS) is a rare entity. DGS has been proposed as a unifying term referring to symptoms attributed to the various pain generators located in this region. While not all-inclusive, the diagnosis of DGS allows for focus on pathology of regionally associated muscles, tendons, and nerves in the clinical evaluation and management of posterior hip and buttock complaints. An understanding of the anatomic structures and their kinematic and topographic relationships in the deep gluteal space is pivotal in making accurate diagnoses and providing effective treatment. Because presenting clinical features may be unrevealing while imaging studies and diagnostic procedures lack supportive evidence, precise physical examination is essential in obtaining accurate diagnoses. Management of DGS involves focused rehabilitation with consideration of still clinically unproven adjunctive therapies, image-guided injections, and surgical intervention in refractory cases.
Proprioceptive Neuromuscular Facilitation method in physiotherapy in patients after mastectomy
Authors: Filarecka Agnieszka , Jęchorek Michał 
Published: June 2021

Rehabilitation in the course of breast cancer is an indispensable part of the treatment. The implementation of rehabilitation in the form of kinesitherapy should also take place in the pre-treatment period, so as to compensate for the possibility of complications associated with immobilisation of the patient after mastectomy. In most studies on post-mastectomy rehabilitation, emphasis is placed on anti-anginal prophylaxis and lymphedema therapy. The article aims to present treatment proposals that use the concept of PNF in improved postmastectomy patients. This method, known since the 90's, is often reserved for patients with neurological damage, but can also be successfully used in other patient groups using its main principles and philosophy of therapeutic goals. The article presents examples of activities that can be used in therapy in various phases. The paper presents the method of using the method associated with the upper limb dysfunction after mastectomy, which can be freely modified for the purposes of superior therapy. A review of available literature and own experience was used.
Role of the autonomic nervous system and lipoperoxidation in immunotropic effects of nitrogenous metabolites in patients with postradiation encephalopathia
Authors: Kuchma Igor , Gozhenko Anatoliy , Flyunt Igor-Severyn , Ruzhylo Sofiya , Nahurna Yaryna , Zukow Walery , Popovych Igor 
Published: June 2021

Background. We have previously shown that nitrogenous metabolites have immunomodulatory effects, both suppressor and enhancing, both in healthy rats and in humans exposed to pathogenic influences. The immunomodulatory effect of bilirubin is probably mediated through aryl hydrocarbon receptors, and uric acid through TL- and adenosine receptors of immune cells. The question of mediators of the immunomodulatory action of urea and creatinine remains open. We hypothesized the mediating role of mediators of the autonomic nervous system. A strong correlation was found between the constellation of nitrogenous metabolites, on the one hand, and the HRV markers of ANS, on the other hand. The aim of this study is to analyze the relationships between HRV markers of the parameters of the ANS as well as Lipoperoxidation, on the one hand, and the parameters of Immunity - on the other hand. Material and methods. The object of observation in 1997 were 19 men and 3 women who were exposed to pathogenic factors of the accident at the Chоrnobyl nuclear power plant during the liquidation of its consequences in 1986-87. The survey was conducted twice - on admission and after two weeks of rehabilitation at the Truskavets’ Spa. The state of the autonomic nervous system (ANS) was judged by the HRV parameters recorded before and after submaximal bicycle ergometric loading. The state of lipid peroxidation assessed the content in the serum diene conjugates, malonic dyaldehid, activity of catalase serum and superoxide dismutase erythrocytes. Results. The coefficient of canonical correlation between the constellation of HRV markers of ANS and parameters of Immunity was 0,947 (χ2(126)=178; p=0,002) The inclusion in factor structure parameters of Lipoperoxidation increases R to 0,973 (χ2(231)=314; p<10-6). Conclusion. Previously identified immunomodulatory effects of urea and creatinine as well as uric acid and bilirubin are realized, possibly, through cholinergic and adrenergic mechanisms as well as reactive oxygen species.
Relationships between geomagnetic Ар-indeх and parameters of the immunity in patients with multiple sclerosis and radiculopathies
Authors: Popovych Igor , Gozhenko Anatoliy , Badiuk Nataliya , Napierała Marek , Muszkieta Radosław , Zukow Walery , Yanchij Roman , Lapovets’ Natalia , Lapovets’ Lyubov , Tserkovnyuk Ruslan , Akimova Viorica , Nahurna Yaryna , Martianova Olha , Vivchar Roman , Chendey Ivanna , Ruzhylo Sofiya 
Published: June 2021

Background. The effect of geomagnetism on human immunity has so far been studied through long-term observations. We set ourselves the goal of detecting the immediate immunotropic effects of the Earth's magnetic field by analyzing the relationships between immunity parameters and the geomagnetic Ap-index. Material and methods. The object of observation were 74 patients with multiple sclerosis and 14 patients with radiculopathies, who in the period from September 2014 to November 2018 conducted a one-time assessment of immune status by the relative content in the blood of lymphocytes of CD3+, CD4+, CD8+, CD25+, CD56+ and CD19+ phenotypes and serum level of Immunoglobulines M, G, A as well as CIC and IL-1β. On the day of blood capture and during the previous 7 days, retrospectively recorded the geomagnetic Ap-index, using a publicly available information resource http://wdc.kugi.kyoto-u.ac.jp/kp/index.html. Results. During the week, the average level of Ap-index ranged from 12÷20 nT. The correlation coefficients between the Ap-index on the day of blood collection and 1, 3 and 7 days before it and the level of CD3+CD4+ lymphocytes were -0,57; -0,48; -0,55 і -0,52 respectively, while on other days were in the range of -0,35÷0,05. In contrast, with the level of CD56+ lymphocytes Ap-index correlates positively and almost mirror (0,56; 0,43; 0,54 і 0,57 respectively and 0,34÷-0,08), due to the reciprocity of their levels (r=-0,80). Also positive, but much weaker, correlates the Ap-index with the level of CD25+ lymphocytes (0,35; 0,25; 0,45 і 0,31 respectively and 0,22÷-0,14). In contrast, with the level of IL-1β Ap-index correlates significantly only on the day of blood collection and 2 days before (r=0,21 and 0,31 respectively), and with other registered parameters of immunity the correlation is insignificant. The canonical correlation between Ap-indices for 7 days before and on the day of blood collection, on the one hand, and the levels of CD4+, CD56+, CD25+ and CD8+ lymphocytes and the concentration of IgM and IL-1β - on the other hand, was very strong: R=0,741; R2=0,549; χ2(42)=130; p<10-6. Conclusion. Disturbances of the geomagnetic field (Ap-index) has a significant immediate modulating effect on the level of immune parameters in the blood, mostly T-helpers (suppressor) and natural killers (enhancing).
Acceptance of illness and quality of life in patients with type 2 diabetes
Authors: Krzemińska Sylwia Anna , Kostka Anna Maria 
Published: June 2021

Background: results of studies concerning the quality of life in chronic diseases and the predictors thereof are a source of valuable information making it possible to take the right actions, both educational, at every stage, and therapeutic. The assessment acceptance of illness and the quality of life enables the identification of patients' actual problems and objections as well as the recognition of their needs for the purpose of treatment optimization.Objective: The aim of the study was to evaluate the acceptance of the disease and the quality of life of patients with type 2 diabetes.Materials and methods: The study assessed disease acceptance and the quality of life in 194 people living with type 2 diabetes for over 10 years. The AIS (Acceptance of Illness) and WHOQoL –BREF questionnaires were used.Results: Acceptance of illness in the study group was average 24.21 points (SD=8.61).Patients are not satisfied with the quality of their life and their own health. According to the assessment of patients, the quality of their life is the highest in the social domain (mean13.72±2.18), slightly worse in the environmental domain (mean 13.31±2.1) and it is the worst in the mental (mean12.82±2.78) and physical (mean 12.02±3.24) domain. The AIS result significantly and positively correlated with each domain of life (all of them p<0.05), therefore, the higher the AIS result (better acceptance of illness).Conclusion: Acceptance of illness is an independent predictor of the quality of life in terms of the perception of own health and the perception of the quality of life in general. It also affects all domains of life. The greater the acceptance of illness, the higher the quality of life in all domains.