bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abernethy Malformation Type II in a 70-Year-Old Patient with Angina Pectoris
Authors: Gandileva V. , Makaveeva P. , Tabakova D. , Valerieva T. , Simova I. , Petkov P. , Niagolova S. , Hristov V. , Poposki S. , Dimitrov N. , Vekov T. 
Published: November 2021

Abstract
Congenital extrahepatic portosystemic shunts (ECPSS) are rare developmental anomalies in which a variable portion of the portal blood bypasses the liver and is shunted in the systemic circulation via one or more aberrant vessels. We present a clinical case of a 70-year-old man, who was referred to the Cardiology Department because of exertional dyspnea, fatigue, and feeling of heaviness and pressure behind the sternum. MDCT of the aorta was performed and an aberrant vessel was discovered with communication with the left iliac vein on one side and superior mesenteric and splenic veins on the other. The portal vein was hypoplastic. The radiologic findings were suggestive of malformation of Abernethy. The ECPSS can be classified into 2 main groups (with complete and partial shunting). The patients have different clinical presentation. Some of them are completely asymptomatic while in others the shunt can manifest even before birth as fetal growth retardation or in the early neonatal period with neonatal cholestasis and galactosemia. Common complications are hepatic encephalopathy and hepatopulmonary syndrome and there is a wide variety of concomitant abnormalities. The imaging modalities play a crucial role in the diagnosis, classification, follow-up and the proper choice of therapeutic management in patients with ECPSS.
A Rare Case of Juvenile X-Linked Retinoschisis
Authors: Mermeklieva E. , Vasileva P. 
Published: November 2021

Abstract

Aim: To present a rare clinical case of X-linked retinoschisis, confirmed clinically, electrophysiologically and genetically.

Material and methods: A 12-year-old boy underwent detailed ophthalmic examination including fundus photography, full-field, multifocal and pattern electroretinography, visual field testing, optical coherence tomography, which established the clinical diagnosis, confirmed also genetically.

Results: The clinical findings included a slight loss of vision, central and paracentral scotomas, a characteristic spoke-wheel pattern appearance of the macula in fundoscopy and the pathognomic appearance of splitting of the retinal layers in the macula with foveal schisis with cystic spaces on OCT. Reduced cone and rod ERG responds were detected with the characteristic decreasing of b-ware near the isoelectric line. The genetic analysis found that the patient was hemizygous for the missense mutation c.598G>A (p.Arg200Cys) of RS1 gene, coming from his asymptomatic mother.

Conclusion: The comprehensive clinical, electrophysiological and genetic testing of patients with rare hereditary retinal dystrophies is essential for the correct diagnosis and the choice of therapeutic approach.
Significance of the Dominant Psychological and Physiological Aspects of the Occupational Stress Models
Authors: Simeonova S. , Nikolova R. 
Published: November 2021

Abstract
The importance of the dominant psychological and physiological aspects of occupational stress models is a significant topic for researchers working in the field of medicine. Modern society faces significant problems in the detection and management of stress due to its growing impact on the functional state of working individuals. Ensuring safe and healthy working conditions is necessary to deal with the adverse effects of occupational stress on health. Controlling and reducing stress is possible by revealing the causal psychophysiological links in the mechanisms of work-related stress. Scientifically based stress management is based on the categories and concepts underlying occupational stress models. Modern work-related models of stress describe and study not only the adverse characteristics of the work process, but also the factors that stimulate the health and well-being of the individual. Monitoring occupational stress is part of the process of neutralizing and eliminating it. In today’s dynamic world, it is not enough to expect only quality performance of the professional duties of employees, but the commitment of managers working in the field of health care is needed to analyse and manage the dominant psychological and physiological aspects of occupational stress models and prevent adverse aspects of models of this type of stress at work.
Current Knowledge About the Implication of Bacterial Microbiota in Human Health and Disease
Authors: Nikolova D. 
Published: November 2021

Abstract
Recent advances in molecular genetics and the invention of new technologies led to a development in our knowledge about human microbiota, specifically bacterial one. The microbiota plays a fundamental role in the immunologic, hormonal and metabolic homeostasis of the host. After the initiation of the Human Microbiome Project, it became clear that the human microbiota consists of the 10-100 trillion symbiotic microbial cells harbored by each person, primarily bacteria in the gut, but also in other spots as the skin, mouth, nose, and vagina. Despite of the differences in studying bacterial species, decreased bacterial diversity and persistence has been connected with several diverse human diseases primarily diabetes, IBD (inflammatory bowel disease) and others; attempts were made even to explain psychiatric pathology. Several species emerged as dominant and were clearly linked to certain disorders or accepted as biomarkers of others. The current review aims to discuss key issues of our current knowledge about bacteria in human, the difficulties and methods of its analysis, its contribution to human health and responsibility for human diseases.
Current Trends in the Gene Therapy of Hematologic Disorders
Authors: Nikolova D. 
Published: November 2021

Abstract
Recent advances in molecular genetics and the invention of new technologies led to an advance in the development of gene therapy. Gene therapy is used to correct defective genes in order to cure a disease or help the body better fight a disease. It works by restoring or modifying cellular functions through the introduction of a functional gene into the target cell. The concept of gene therapy is simple, but introducing it to routine clinical practice is not. The main concerns are related to some safety issues as well as to the problem that maintaining a stable and prolonged expression in target cells may not be easily achieved. In spite of the difficulties, gene therapy remains a hope for many hematological disorders that cannot be effectively treated so far. This article reviews the current status of gene therapy with a focus on hematological disorders. In addition, clinically applied approaches are presented through particular examples of approved gene therapy drugs.
Possible Hypothetical Mode of Action of ECT (Electroconvulsive Therapy) Based on DNA Dipole Character and Epigenetics
Authors: Koch H. J. 
Published: November 2021

Abstract
The human genome consists of roughly 23000 genes which cannot explain the enormous diversity of proteins or behavior. A second epigenetic code warrants adaptive variation of gene expression. The rationale of this variation are transfer reactions such as methylation, acetylation or phosphorylation of DNA or histones including reverse reactions which are supposed to be altered by electroconvulsive therapy (ECT). The method has been successfully used since the 1930ies but the underlying molecular mechanism of action has not been elucidated yet. The paper discusses the theoretical involvement of epigenetic gene expression as an adaptive process to explain biochemical changes after ECT administration.
Physical Activity and Rehabilitation – A Key to Healthy Aging
Authors: Mihaylova V. , Ivanova I. , Alakidi A. , Kilova K. , Liochkova M. 
Published: November 2021

Abstract
A doctrine was established regarding the so called “new beginning” – the transition to the post-retirement period for a full-value experience of the available compensatory reserves and creation of overcoming strategies for opposing and coping with the obstacles in the still uncommon lifestyle of the senior citizen. By outlining the role of physical activity in a synthesized format, a successful attempt for data classification worldwide was made; in one fourth of the elderly people there is insufficient physical activity, more evident in the women and for Bulgaria this percent is higher (95%). The role and effect of categorized physical exercises for mobility, flexibility, and stretching, aerobic and anaerobic movements have been pointed out. Moreover, the review discusses the preventive effects of rehabilitation, including psychological ones and the role of it in helping patients live with socially significant diseases, coping with disability. The contribution of physical activity and rehabilitation as protective factors of non-infectious diseases is associated with good mental health, improved quality of life and well-being. Within this meaning, while contemporary medicine adds years to life, physical activity and mostly rehabilitation is a significant reason for adding a meaningful life in the course of aging and old age.
Association of X Chromosome Aberrations with Male Infertility
Authors: Xharra S. , Behluli E. , Moder A. , Nefic H. , Hadziselimovic R. , Temaj G. 
Published: November 2021

Abstract
Male infertility is caused by spermatogenetic failure, clinically noted as oligoor azoospermia. Approximately 20% of infertile patients carry a genetic defect. The most frequent genetic defect leading to azoospermia (or severe oligozoospermia) is Klinefelter syndrome (47, XXY), which is numerical chromosomal abnormality and Y- structural chromosome aberration. The human X chromosome is the most stable of all human chromosomes. The X chromosome is loaded with regions of acquired, rapidly evolving genes. The X chromosome may actually play an essential role in male infertility and sperm production. Here we will describe X chromosome aberrations, which are associated with male infertility.
Potential of graded doses of neem (Azadirachta indica) seed oil on ruminal fermentation characteristics, degradability, and methane formation in vitro
Authors: Al-Marzooqi Waleed , Sallam Sobhy M. , Alqaisi Othman , El-Zaiat Hani M. 
Published: November 2021

Abstract
Neem (Azadirachta indica) belongs to Meliaceae family, represented mainly by trees, and widely cultivated and adapted in many tropical regions. The objective of this study was to evaluate the effect of increasing doses of neem seed oil (NSO) on ruminal methane (CH4) formation, diet degradability, and fermentation characteristics after 24 h of in vitro incubation. Treatments were randomly designed to four doses of NSO supplemented to the basal diet (0, 20, 40, or 60 ml/kg DM). Increasing NSO dose resulted in a quadratic decrease (P < 0.05) in net gas (expressed as ml/g DM and ml/g TDOM) and CH4 (expressed as ml/g TDNDF) production, while CH4 (expressed as ml/g TDOM), acetate and propionate proportions decreased linearly confirming a dose-related effect. A quadratic increase in TDOM and linear increase (P = 0.023) in DNDF, NH3-N concentrations, and total protozoal counts were observed. However, a linear increase (P = 0.009) was found in the ruminal butyrate proportion and partitioning factor as dietary NSO supplementation increased. In conclusion, dietary NSO supplementation mediated some desirable fermentation patterns, reducing ruminal NH3-N concentration and CH4 production with some adverse effects on fiber degradability. However, practical research under long-term conditions is required for further investigation.
Prenatal programming of the small intestine in piglets: the effect of supplementation with 3-hydroxy-3-methylbutyric acid (HMB) in pregnant sows on the structure of jejunum of their offspring
Authors: Tomaszewska Ewa , Prost Łukasz , Dobrowolski Piotr , Chand Deepesh K.P. , Donaldson Janine , Czech Anna , Klebaniuk Renata , Fabjanowska Julia , Muszyński Siemowit 
Published: November 2021

Abstract
When discussing the scale of the occurrence of diseases of the digestive system in farm animals, particularly pigs in the weaning period, it may be beneficial to study physiological and nutritional factors that could potentially affect the growth, development, and modelling of the structure and function of the digestive tract. Taking into account the reports on the beneficial effects of ß-hydroxy-ß-methylbutyrate (HMB) administration in the prenatal period on the development of various systems it was assumed that the HMB supplementation to pregnant sows can influence intestinal development in the offspring during weaning. Thus, the present experiment was conducted to evaluate the effect of HMB treatment of pregnant sows on jejunum development in offspring at weaning. From 70th day until the 90th day of gestation, sows received either a basal diet (n = 12) or the same diet supplemented with HMB (n = 12) at the dose of 0.2 g/kg of body weight/day. HMB given during prenatal time reduced the thickness of the longitudinal muscle; the apoptotic cell index in epithelium also significantly decreased after the HMB supplementation. Vasoactive intestinal (poly)peptide (VIP) expression in submucosal ganglia significantly increases in prenatally HMB treated piglets. The same strong reaction was observed with the expression of occludin, claudin-3, E-cadherin, and leptin in the jejunal epithelium. The obtained results indicate that the administration of HMB to pregnant sows significantly influenced the expression of VIP, leptin and some proteins of the intestinal barrier of their offspring less influencing the basal morphology.
Breast muscle myopathies in broiler: mechanism, status and their impact on meat quality – A review
Authors: Nawaz Ali Hassan , Zheng Jia Hui , Zhang Wei Lu , Wang Fu Jian , Jiao Zheng Hai , Amoah Kwaku , Zhang Li 
Published: November 2021

Abstract
Almost a decade ago, the sudden rise of breast muscle defects in fast-growing commercial broiler breeds challenged the broiler production industry and meat scientists to address the issue of these novel muscle abnormalities. After that, a widespread hypothesis showing a correlation between high muscle yield and incidence of these muscle myopathies received much acceptance from the research community. Increased muscle hypertrophy and unbalanced growth of connective tissues lead to an inadequate blood supply that ultimately causes hypoxia in muscle fibers. Reduced blood vascular density in muscle fibers induces oxidative stress and mitochondrial dysfunction, leading to muscle fibrosis, lipidosis and myodegeneration. Along with physical changes, the myopathic muscles exhibit poor sensory properties, abnormal texture properties and a low nutritional profile. As these myopathies alter meat’s physical appearance, they have a negative impact on customer’s behavior and preference. A better production environment with proper dietary supplementation with balanced breeding strategies can minimize the incidence of muscle myopathies in broiler chicken. This review aims to address the underlying mechanism behind these myopathies and their impact on poultry meat quality, including nutritional value and consumer behavior. It describes the link between genetic and non-genetic elements influencing myopathies, along with the strategies to minimize the occurrence of breast muscle myopathies.
The effect of light/dark cycles on performance and welfare in broiler
Authors: Ozkan Murat , Simsek Ulku Gulcihan 
Published: November 2021

Abstract
The purpose of this study was to compare a continuous lighting programme (23 hours of lighting (L)/1 hour of darkness (D)) with intermittent lighting programmes (16L: 8D) and also to investigate the effects of the length of the dark cycle in the intermittent programme on the performance, carcass characteristics, water consumption, uniformity, metabolic parameters, and ammonia burns of chickens. Thus, five hundred Ross 308 male chicks were used. The 23L:1D programme was applied to the chicks for 7 days. On day 7, they were divided into four groups by balancing their live weight; group I: continuous 23L:1D; group II: intermittent 4x (4L:2D); group II: intermittent 2x (8L:4D); group IV: continuous 16L:8D. The study took place between days 7 and 42. At the end of the study, 10 chickens from each group were slaughtered, their carcass, blood, and bone properties were analysed. Body temperatures and ammonia burns were assessed for all broiler chickens. The mean live weight of group IV was the lowest. The difference among the groups in terms of live weight gains, feed intakes, feed conversion ratios, and survival rates was non-significant. Long-term darkness in group IV significantly dropped the water consumption. On day 21, group III’s best uniformity was calculated; but on day 42, the difference was non-significant. The highest breast ratio and the lowest wing ratio belonged to chicks in group I. Their free T4, glucose, and uric acid levels were lower; whilst their testosterone levels were higher. Body temperature and tibia ash levels were similar across all of the groups. The intermittent lighting programmes increased the number of ammonia burns. Consequently, the long-term darkness negatively affected both the chickens’ performance and well-being.
Dose-response effects of the Savory (Satureja khuzistanica) essential oil and extract on rumen fermentation characteristics, microbial protein synthesis and methane production in vitro
Authors: Golbotteh Mostafa Mehdipour , Malecky Mostafa , Aliarabi Hasan , Zamani Pouya , Ganjkhanlou Mehdi 
Published: November 2021

Abstract
The objective of the present study was to investigate dose-response effects of the essential oil (EO) and dry extract (EX) of Satureja khuzistanica (SK) on in vitro gas production kinetics, rumen fermentation, ruminal methanogenesis and microbial protein synthesis. So, EO and EX were tested at 0 (as control); 150 (low dose); 300, 450 (intermediate doses) and 600 mg/L (high dose). The gas produced over 24 h of incubation (GP24) decreased linearly with both EO and EX dosages (P<0.01). In vitro methane production was reduced by both EO (14–69%, depending on the included dose) and EX (7–58%). Microbial protein (MP) as well as the efficiency of microbial protein synthesis (EMPS) were improved by EO (18.8–49.8% and 20.4–61.5% for MP and EMPS, respectively) and to a lesser extent by EX (8.3–25.7% and 4.6–24.2% for MP and EMPS, respectively). Ammonia concentration was dropped in linear and quadratic manners with EO (P<0.05), and linearly with EX dosages (P<0.01). EO and EX exhibited depressive effects (in linear and quadratic (P<0.05), and linear manners (P<0.01), respectively) on total protozoa count. A mixed linear and quadratic effect was observed from both EO and EX on total VFA concentration (P<0.01). Total VFA concentration increased at 300 mg/L of EX, but decreased at high dose of both EO and EX. The acetate proportion increased with EO intermediate and high dosages, but it decreased at the expense of propionate at low and intermediate doses of EX. In total, these findings confirmed previous research on the great capacity of plant-based feed additives in positively modulating rumen fermentation that their effects may vary depending on the doses used. Specifically, these results suggest that EO and EX have high potentials to improve rumen functions at intermediate doses, which needs to be confirmed by in vivo experiments.
Dietary silage supplement modifies fatty acid composition and boar taint in pork fat
Authors: Argemí-Armengol Immaculada , Villalba Daniel , Bertolín Juan Ramón , Latorre María Ángeles , Panella-Riera Núria , Álvarez-Rodríguez Javier 
Published: November 2021

Abstract
In organic pig husbandry, the use of roughage is mandatory as dietary supplement. This study investigated the effects of oat silage on the fatty acid composition, in entire males and gilts, as well as indole and skatole levels in perirenal adipose tissue of entire males. Entire males and gilts (forty-five to forty-eight pigs/sex) were assigned to two dietary roughage feeds (control with straw vs. oat silage). There was no significant effect of silage or sex on total SFA and MUFA in pork fat. However, the oat silage increased the total PUFA n-3 and decreased the PUFA n-6/n-3 ratio. The content of boar taint compounds (skatole and indole) in the entire male pigs did not differ between diets, although human nose scoring rejected in a greater extent more pork fat from entire males supplemented with oat silage, compared with those only supplied with straw. Approximately 50% of the entire males (90 to 97 kg of carcass) had low skatole values (≤0.1 μg/g), that were below the range of boar taint detection, regardless of the feeding regime. This finding indicates that more studies should be performed to avoid the problem of taint detection in entire males under organic production.
Profitability and Impact of Inorganic Fertilizers on the Maize Production in Ekona, Cameroon
Authors: Nanganoa Lawrence Tatanah , Ngome Francis Ajebesone , Ngong Juliana Namein , Atache Sone Kone Edigar , Ebonlo Jeremiah Ndande , Njukeng Jetro Nkengafac 
Published: November 2021

Summary
Declining soil fertility and low fertilizer use are the major abiotic factors limiting the maize production in Cameroon. Therefore, the design and introduction of appropriate fertilizer schemes, which would improve maize yields and provide incentives for smallholder farmers, are considered imperative. In 2018, a field experiment was conducted on the farm of the Institute of Agricultural Research for Development (IRAD) in Ekona, the south-west region of Cameroon, to investigate the profitability and impact of inorganic fertilizers on maize production. The experiment was laid out in a randomized complete block design with four replications and four treatments, using different fertilizer rates per hectare in each treatment (namely unfertilized control (T1), 50 kg urea + 50 kg N-P-K (T2), 100 kg urea + 100 kg N-P-K (T3) and 150 kg urea + 150 kg N-P-K (T4)). The results obtained indicate that all the maize growth parameters (plant height, number of leaves per plant, stem girth and leaf area) and yield components considered (cob length, cob diameter and test weight of 100 grains) were significantly (P < 0.05) higher in T4 than T1. The grain yields recorded ranged from 4.09–5.88 t ha−1 and were also statistically (P < 0.05) higher in T4 than T1. The incremental income based on the fertilizer use was the highest in T4, followed by T3 and T2. The value cost ratio (VCR) was greater than 2 in all the treatments and was found to be highest in T2 (3.15), followed by T4 (2.52) and T3 (2.49). As T2, T3 and T4 did not differ statistically (P > 0.05), all the fertilizer rates considered were economically viable, but T4 provide the most cost-effective due to its higher grain yields and incremental income.
Influence of Total Production on the Planting Structure of Significant Vegetable Crops in the Republic of Serbia
Authors: Tekić Dragana , Novković Nebojša , Mutavdžić Beba , Pokuševski Maja , Zoranović Tihomir 
Published: November 2021

Summary
The purpose of this paper is to examine, on the basis of the total production and distribution area parameters analyzed, a potential relationship between the actual production of major vegetable crops in Serbia in the current year and the following year’s distribution of planting areas devoted to the crops considered. The analysis was performed for the period 2005-2019. The results obtained indicate that the current year’s production of certain vegetable crops such as potatoes, cabbage, kale, peppers and beans affect the following year’s distribution of their planting areas.