bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain activation during the observation of real soccer game situations predicts creative goal scoring
Authors: Rominger Christian , Koschutnig Karl , Memmert Daniel , Papousek Ilona , Perchtold-Stefan Corinna M , Benedek Mathias , Schwerdtfeger Andreas R , Fink Andreas 
Published: March 2021

Abstract
Creativity is an important source of success in soccer players. In order to be effective in soccer, unpredictable, sudden and at the same time creative (i.e. unique, original and effective) ideas are required in situations with high time pressure. Accordingly, creative task performance in soccer should be primarily driven by rapid and automatic cognitive processes. This study investigated if functional patterns of brain activation during the observation/encoding of real soccer game situations can predict creative soccer task performance. A machine learning approach (multivariate pattern recognition) was applied in a sample of 35 experienced male soccer players. The results revealed that brain activation during the observation of the soccer scenes significantly predicted creative soccer task performance, while brain activation during the subsequent ideation/elaboration period did not. The identified brain network included areas such as the angular gyrus, the supramarginal gyrus, the occipital cortex, parts of the cerebellum and (left) supplementary motor areas, which are important for semantic information processing, memory retrieval, integration of sensory information and motor control. This finding suggests that early and presumably automatized neurocognitive processes, such as (implicit) knowledge about motor movements, and the rapid integration of information from different sources are important for creative task performance in soccer.
Sleep-dependent prospective memory consolidation is impaired with aging
Authors: Leong Ruth L F , Lo June C , Chee Michael W L 
Published: March 2021

Abstract

Study Objectives
Existing literature suggests that sleep-dependent memory consolidation is impaired in older adults but may be preserved for personally relevant information. Prospective memory (PM) involves remembering to execute future intentions in a timely manner and has behavioral importance. As previous work suggests that N3 sleep is important for PM in young adults, we investigated if the role of N3 sleep in PM consolidation would be maintained in older adults.

Methods
Forty-nine young adults (mean age ± SD: 21.8 ± 1.61 years) and 49 healthy older adults (mean age ± SD: 65.7 ± 6.30 years) were randomized into sleep and wake groups. After a semantic categorization task, participants encoded intentions comprising four related and four unrelated cue-action pairs. They were instructed to remember to perform these actions in response to cue words presented during a second semantic categorization task 12 h later that encompassed either daytime wake (09:00 am–21:00 pm) or overnight sleep with polysomnography (21:00 pm–09:00 am).

Results
The significant condition × age group × relatedness interaction suggested that the sleep benefit on PM intentions varied according to age group and relatedness (p = 0.01). For related intentions, sleep relative to wake benefitted young adults’ performance (p &lt; 0.001) but not older adults (p = 0.30). For unrelated intentions, sleep did not improve PM for either age group. While post-encoding N3 was significantly associated with related intentions’ execution in young adults (r = 0.43, p = 0.02), this relationship was not found for older adults (r = −0.07, p = 0.763).

Conclusions
The age-related impairment of sleep-dependent memory consolidation extends to PM. Our findings add to an existing body of work suggesting that the link between sleep and memory is functionally weakened in older adulthood.
Loss of putative GABAergic neurons in the ventrolateral medulla in multiple system atrophy
Authors: Schmeichel Ann M , Coon Elizabeth A , Parisi Joseph E , Singer Wolfgang , Low Phillip A , Benarroch Eduardo E 
Published: March 2021

Abstract

Study Objectives
Multiple system atrophy (MSA) is associated with disturbances in cardiovascular, sleep and respiratory control. The lateral paragigantocellular nucleus (LPGi) in the ventrolateral medulla (VLM) contains GABAergic neurons that participate in control of rapid eye movement (REM) sleep and cardiovagal responses. We sought to determine whether there was loss of putative GABAergic neurons in the LPGi and adjacent regions in MSA.

Methods
Sections of the medulla were processed for GAD65/67 immunoreactivity in eight subjects with clinical and neuropathological diagnosis of MSA and in six control subjects. These putative GABAergic LPGi neurons were mapped based on their relationship to adjacent monoaminergic VLM groups.

Results
There were markedly decreased numbers of GAD-immunoreactive neurons in the LPGi and adjacent VLM regions in MSA.

Conclusions
There is loss of GABAergic neurons in the VLM, including the LPGi in patients with MSA. Whereas these findings provide a possible mechanistic substrate, given the few cases included, further studies are necessary to determine whether they contribute to REM sleep-related cardiovagal and possibly respiratory dysregulation in MSA.
The effect of time of feeding on plasma amino acids during exercise and recovery in horses
Authors: Graham-Thiers Patty M , Bowen LaAnn K 
Published: March 2021

Abstract
Feeding management in horses suggests feeding horses in advance of exercise, particularly the grain portion of the diet. Plasma amino acids (AA) peak at 3 to 6 h postfeeding depending on the AA. The timeframe between feeding and exercise may affect the availability of AA during and after exercise. The purpose of this study was to observe the differences in plasma AA in horses fed prior to exercise or after exercise. Eight light type horses were fed a diet with adequate protein and AA for horses in light to moderate exercise. After an adjustment period, horses completed a standardized exercise test (SET). Relative to the SET, horses were fed either 2 h prior (PRE horses) to the SET, 1 h after completing the SET (POST horses), or horses remained fasted throughout the sampling period (FASTED horses). Plasma was drawn prior to exercise, at the peak of exercise as well as at 1, 2, 4, and 7 h postexercise. Plasma was analyzed for AA, glucose, lactate, creatinine, creatine kinase, ammonia, urea-N, and 3-methylhistdine. After completion of the SET and sampling period, horses entered a 1-wk recovery period, which was followed by another SET. The protocol repeated until horses rotated through all feeding protocols in the study (three SETs). The majority of the plasma AA were elevated in PRE horses compared with POST horses prior to the SET until 2 h postexercise where POST horses’ plasma AA concentrations became elevated and remained elevated until the end of the sampling period. In that same time frame, plasma AA for the PRE group decreased out to the end of the sampling period. The elevation of plasma AA in POST horses would be expected as they were fed at 1 h postexercise, whereas PRE horses were reaching a 4 h postfeeding time frame at this point. This elevation was not observed for plasma concentrations of isoleucine, leucine, methionine, and histidine. Concentrations of these AA initially were greater for POST horses in the postexercise period; however, they declined more rapidly than the other AA. The rapid decrease of some of the plasma AA concentrations may suggest uptake by muscle for recovery. This in conjunction with a decrease in plasma creatine kinase concentrations for POST horses suggests that feeding postexercise may facilitate better muscle protein balance (synthesis vs. breakdown) in the recovery period following exercise.
Do knowledge about sodium, health status by self-report, and having hypertension predict sodium consumption behaviors among Southern California hospital employees?
Authors: D’Addario Lia , Kuo Tony , Robles Brenda 
Published: March 2021

Lay Summary
A major problem in the United States is the overconsumption of high sodium foods. These foods often put people at higher risk of hypertension, heart disease, and stroke. Recent public health efforts have tackled this problem by making it easier to select/purchase healthier, lower sodium foods in different settings. Hospital employees are one such group that has been the focus of these interventions. Presently, little is known about what explains sodium-related dietary behaviors among hospital employees. To address this gap, we used data from a survey of hospital staff who were exposed to sodium reduction interventions in the workplace to examine how their knowledge, attitudes, and self-reported health status affected their sodium consumption. A key finding was being in “good health” and having the belief that salt intake matters for health predicted decreased sodium consumption among the survey participants. These and other study findings provide context and insights into ways in which further sodium reduction could be achieved among at-risk hospital employees.
Retrosplenial Cortex Contributes to Network Changes during Seizures in the GAERS Absence Epilepsy Rat Model
Authors: Wachsmuth Lydia , Datunashvili Maia , Kemper Katharina , Albers Franziska , Lambers Henriette , Lüttjohann Annika , Kreitz Silke , Budde Thomas , Faber Cornelius 
Published: March 2021

AbstractResting state-fMRI was performed to explore brain networks in Genetic Absence Epilepsy Rats from Strasbourg and in nonepileptic controls (NEC) during monitoring of the brain state by simultaneous optical Ca2+-recordings. Graph theoretical analysis allowed for the identification of acute and chronic network changes and revealed preserved small world topology before and after seizure onset. The most prominent acute change in network organization during seizures was the segregation of cortical regions from the remaining brain. Stronger connections between thalamic with limbic regions compared with preseizure state indicated network regularization during seizures. When comparing between strains, intrathalamic connections were prominent in NEC, on local level represented by higher thalamic strengths and hub scores. Subtle differences were observed for retrosplenial cortex (RS), forming more connections beyond cortex in epileptic rats, and showing a tendency to lateralization during seizures. A potential role of RS as hub between subcortical and cortical regions in epilepsy was supported by increased numbers of parvalbumin-positive (PV+) interneurons together with enhanced inhibitory synaptic activity and neuronal excitability in pyramidal neurons. By combining multimodal fMRI data, graph theoretical methods, and electrophysiological recordings, we identified the RS as promising target for modulation of seizure activity and/or comorbidities.
Continuous Physiological Monitoring Improves Patient Outcomes
Authors: Stellpflug Courtney , Pierson Laura , Roloff Devin , Mosman Elton , Gross Tera , Marsh Scott , Willis Valerie , Gabrielson Donald 
Published: March 2021

ABSTRACT:

Background:
General patient acuity is increasing in the United States, with more patients having multiple comorbidities and acute-on-chronic conditions. Hospitalizations may also be complicated by serious adverse events, often unrelated to the admitting medical diagnosis. In our facility, the late detection of patient deterioration on general medical units often resulted in increased length of stay (LOS) in the ICU and poor patient outcomes.

Purpose:
The purpose of this project was to improve patient surveillance and better identify early signs of patient deterioration through the use of continuous vital sign monitoring technology.

Methods:
To improve detection of patient deterioration, a nurse-led monitoring and response system was developed using a wearable, wireless device for continuous vital sign surveillance. The patient data the device provided was used with early warning scores and sepsis screening protocols for timely goal-directed interventions.

Results:
Ninety-seven percent of patient deterioration events were recognized and treated as a result of this continuous monitoring and response system. Rapid response team activations decreased by 53% between baseline and the intervention period. LOS among patients transferred to the ICU decreased from 2.82 to 2.19 days. Nurse satisfaction with use of the continuous monitoring device was positive, with 74% of nurses surveyed reporting that information provided by the device enhanced decision-making.

Conclusions:
New technology for patient surveillance, in this case a nurse-led monitoring and response system, can be successfully integrated into general care practice. Use of the nurse-led response system helped nurses recognize early signs of deterioration and continue meaningful patient interactions.
Gene and Stem Cell Therapies for Fetal Care: A Review
Authors: O’Connell Amy E. , Guseh Stephanie , Lapteva Larissa , Cummings Christy L. , Wilkins-Haug Louise , Chan Jerry , Peranteau William H. , Almeida-Porada Graça , Kourembanas Stella 
Published: March 2021

(Abstracted from JAMA Pediatr 2020;174(10):985–991)
In utero stem cell transplantation and gene therapy have the ability to cure and treat many different genetic disorders in children and adults. For some conditions, this could be applied before birth and allow for better outcomes, as well as reduce the financial burden put on families with children with genetic disorders.
Exome Sequencing for Prenatal Diagnosis in Nonimmune Hydrops Fetalis
Authors: Sparks Teresa N. , Lianoglou Billie R. , Adami Rebecca R. , Pluym Ilina D. , Holliman Kerry , Duffy Jennifer , Downum Sarah L. , Patel Sachi , Faubel Amanda , Boe Nina M. , Field Nancy T. , Murphy Aisling , Laurent Louise C. , Jolley Jennifer , Uy Cherry , Slavotinek Anne M. , Devine Patrick , Hodoglugil Ugur , van Ziffle Jessica , Sanders Stephan J. , MacKenzie Tippi C. , Norton Mary E. 
Published: March 2021

(Abstracted from N Engl J Med 2020;383:1746–1756)
Nonimmune hydrops fetalis (NIHF) is a condition complicating approximately 1 in 1700 to 3000 pregnancies where the fetus develops an overload of fluid, causing a wide range of outcomes such as stillbirth, preterm birth, neonatal complications, or neonatal death. Standard genetic testing with microarray or karyotype identifies a genetic cause of hydrops approximately only 25% of the time.
Bladder Bacterial Diversity Differs in Continent and Incontinent Women: A Cross-sectional Study
Authors: Price Travis K. , Lin Huaiying , Gao Xiang , Thomas-White Krystal J. , Hilt Evann E. , Mueller Elizabeth R. , Wolfe Alan J. , Dong Qunfeng , Brubaker Linda 
Published: March 2021

(Abstracted from Am J Obstet Gynecol 2020;223:729.e1–729.e10)
Interest has grown since the discovery of the bladder urobiome in determining whether the microbiota in the urobiome play a role in clinical phenotyping and provide opportunities for novel therapeutic approaches for women with the 2 most common forms of urinary incontinence (UI): stress UI (SUI) and urgency UI (UUI). However, previous studies have focused predominantly on UUI, and thus, studies on SUI have been lacking.
Can intraoperative ultrasound visualize the closed reduction and elastic intramedullary nail fixation processes of double forearm fractures in children?
Authors: Yang Xiaodong , Li Lang , Tang Xueyang , Xiang Bo , Wen Tianfu 
Published: March 2021

Abstract
To evaluate the feasibility of utilizing ultrasonography to monitor the fracture reduction and elastic intramedullary nail fixation processes in treating children with double forearm fractures. A retrospective analysis of 30 children with double forearm fractures treated at our hospital between January 2016 and July 2018. The children were aged 3 to 10 years. All patients were treated with closed reduction and internal fixation with elastic intramedullary nails using intraoperative ultrasound monitoring and intermittent radiographic imaging. The closed reduction and fixation were successful in all patients. The operation times ranged from 16 to 30 minutes, averaging 21 minutes. No neurovascular injuries occurred during closed reduction and nail insertion. Moreover, closed reduction was successful in the first attempt in 86.7% of patients. All patient outcomes were optimal, lacking serious complications during follow-ups. Intraoperative ultrasound monitoring can clearly show the shape and changes in fracture ends, distal growth plates, and surrounding soft tissues, and fracture reduction and passage of elastic nail processes at fracture ends during closed reduction; therefore, visualizing closed reductions can be achieved. The combination of intraoperative ultrasound and radiographic imaging can ensure operative effects and significantly reduce radiation exposure for both doctors and patients. An adequately powered prospective randomized trial is required to confirm our findings.
Increased expression of microRNA-26a-5p predicted a poor survival outcome in osteosarcoma patients
Authors: Xie Xiao-Yu , Chen Xian-Ming , Shi Ling , Liu Jun-Wei 
Published: March 2021

Abstract
MicroRNA (miR)-26a-5p is an oncogene significantly associated with osteosarcoma. We try to evaluate expression of circulating miR-26a-5p in osteosarcoma patients and evaluate its significance.
A total of 243 consecutive osteosarcoma patients and 96 healthy participates were enrolled. Circulating miR-26a-5p levels were evaluated by using real-time quantitative reverse transcription polymerase chain reactions (RT-PCR). The association between circulating miR-26a-5p level and survival outcomes was evaluated by univariate and multivariate analysis.
Circulating miR-26a-5p levels in osteosarcoma patients was significantly higher than that of healthy volunteers (P < .05). Upregulated miR-26a-5p was significantly related to advanced cancer and metastasis (both P < .05). Moreover, patients with a high serum miR-26a-5p had a poorer overall survival than those with a low serum miR-26a-5p levels (P < .05). Circulating miR-26a-5p level also been showed as independent risk factor for osteosarcoma in multivariate analysis (hazard ratio [HR], 0.38; 95% confidence interval [CI]: 0.11–0.98; P < .01).
Circulating miR-26a-5p was significantly upregulated in osteosarcoma patients and remarkably associated with poor prognosis, indicating that circulating miR-26a-5p might serve as a useful diagnostic and prognostic biomarker for osteosarcoma.
Effect of nursing intervention to guide early postoperative activities on rapid rehabilitation of patients undergoing abdominal surgery
Authors: Rao Lu , Liu Xinjian , Yu Li , Xiao Hui 
Published: March 2021

Abstract

Background:
Postoperative complications after abdominal surgery are high, and there is no reliable intervention program to prevent them. Some studies have pointed out that early postoperative activities have advantages in preventing the occurrence of complications, but lack of evidence-based basis. The purpose of this study is to systematically evaluate the effect of nursing intervention is guiding early postoperative activities on the rapid recovery of patients undergoing abdominal surgery.

Methods:
China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database and Chinese Biomedical Database, PubMed, Embase, Web of Science and the Cochrane Library will be searched by computer, and a randomized controlled study is conducted on early participation in exercise programs after abdominal surgery from the establishment of the database to January 2021. The language is limited to English and Chinese. The quality of the included study is independently extracted and the literature quality is evaluated by 2 researchers, and the included literature is analyzed by Meta using RevMan5.3 software.

Results:
This study will evaluate the effect of nursing intervention is guiding early postoperative activities on the rapid rehabilitation of patients undergoing abdominal surgery through the indexes of postoperative quality of life score, the incidence of complications, mortality, length of stay and so on.

Conclusion:
This study will provide reliable evidence-based basis for establishing a reasonable and effective postoperative activity guidance program for patients undergoing abdominal surgery.

Ethics and dissemination:
Private information from individuals will not be published. This systematic review also does not involve endangering participant rights. Ethical approval will not be required. The results may be published in a peer-reviewed journal or disseminated at relevant conferences.

OSF Registration number:
DOI 10.17605/OSF.IO/59MD4
Neonatal hereditary spherocytosis caused by a de novo frameshift mutation of the SPTB gene characterized by hydrops fetalis
Authors: Zhang Yimin , Shao Shuming , Liu Jie , Zeng Chaomei , Han Ye , Zhang Xiaorui 
Published: March 2021

Abstract

Rationale:
The etiology of non-immune hydrops fetalis is complex, and its prognosis is poor. One of its main causes is anemia. There are few reports on hydrops fetalis due to anemia caused by hereditary spherocytosis (HS), especially regarding its occurrence in the neonatal period. Thus, we report on a case of neonatal HS caused by a new SPTB gene mutation that was characterized by hydrops fetalis.

Patient concerns:
A neonate with intrauterine hydrops fetalis showed severe hyperbilirubinemia and anemia, reticulocytosis, and hepatosplenomegaly. Laboratory examination findings were normal.

Diagnoses:
Gene sequencing of the patient and his parents showed a de novo frameshift mutation in the patient's SPTB gene. Ultimately, the patient was diagnosed with HS.

Interventions:
Exchange and red blood cell transfusions were performed in the neonatal period.

Outcomes:
The child was discharged from the hospital 14 days postnatal because his hemoglobin and bilirubin levels were stable. Red blood cell transfusion was performed once in infancy; however, no further red blood cell transfusions were required within 2 years of age.

Lessons:
Hydrops fetalis can be a manifestation of HS. Genetic detection can help confirm the diagnosis of suspected neonatal HS undocumented by other laboratory examinations.
Construction of a prognostic value model in papillary renal cell carcinoma by immune-related genes
Authors: Wang Leilei , Gu Weile , Ni Huijun 
Published: March 2021

Abstract
Papillary renal cell carcinoma (PRCC) is the second most common type of renal carcinoma following clear cell renal cell carcinoma, and the role of immune-related genes (IRGs) in tumorigenesis and metastasis is evident; its prognostic value in PRCC remains unclear. In this study, we downloaded the gene expression profiles and clinical data of patients with PRCC from The Cancer Genome Atlas (TCGA) database and obtained IRGs from the ImmPort database. A total of 371 differentially expressed IRGs (DEIRGs) were discovered between PRCC and normal kidney tissues. Prognostic DEIRGs (PDEIRGs) were identified by univariate Cox regression analysis. Then, we screened the four most representative PDEIRGs (IL13RA2, CCL19, BIRC5, and INHBE) and used them to construct a risk model to predict the prognosis of patients with PRCC. This model precisely stratified survival outcome and accurately identified mutation burden in PRCC. Thus, our results suggest that these four PDEIRGs are available prognostic predictors for PRCC. They could be used to assess the prognosis and to guide individualized treatments for patients with PRCC.