bluuebunny/crossref_metadata_2025_split huggingface dataset:
The outburst of a 60 min AM CVn reveals peculiar colour evolution: implications for outbursts in long-period double white dwarfs
Authors: Rivera Sandoval L E , Maccarone T J , Cavecchi Y , Britt C , Zurek D 
Published: May 2021

ABSTRACT
We report on multiwavelength observations during quiescence and of the first detected outburst of the ≈60 min orbital period AM CVn SDSS J113732+405458. Using X-ray and UV observations, we determined an upper limit duration of the event of about 1 yr. The amplitude of the outburst was remarkably small, of around 1 mag in r and 0.5 mag in g. We have also investigated the colour variations of SDSS J113732+405458 and other long-period AM CVns in outbursts and identified a track on the colour–magnitude diagram that is not compatible with the predictions of the disc instability model, suggesting that some outbursts in long-period AM CVns are caused by enhanced mass-transfer. To our knowledge, these are the first studies of the colour evolution in AM CVns. During quiescence we measured an X-ray luminosity for SDSS J113732+405458 of ≈3 × 1029 erg s−1 in the 0.5–10 keV band. This indicates a very low accretion rate, in agreement with the disc instability model for long-period systems. However, such a model predicts stable discs at somewhat long periods. The discovery of this system outburst, along with similarities to the long-period system SDSS J080710+485259 with a comparably long, weak outburst, indicates that these enhanced mass-transfer events may be more common in long-period AM CVns. A larger sample would be needed to determine empirically at what period, if any, the disc instability stops functioning entirely. Finally, we identified an infrared excess in the quiescence spectrum attributable to the donor. This makes SDSS J113732+405458 the second AM CVn to have a directly detected donor.
(6478) Gault: physical characterization of an active main-belt asteroid
Authors: Devogèle Maxime , Ferrais Marin , Jehin Emmanuel , Moskovitz Nicholas , Skiff Brian A , Levine Stephen E , Gustafsson Annika , Farnocchia Davide , Micheli Marco , Snodgrass Colin , Borisov Galin , Manfroid Jean , Moulane Youssef , Benkhaldoun Zouhair , Burdanov Artem , Pozuelos Francisco J , Gillon Michael , de Wit Julien , Green Simon F , Bendjoya Philippe , Rivet Jean-Pierre , Abe Luy , Vernet David , Chandler Colin Orion , Trujillo Chadwick A 
Published: May 2021

ABSTRACTIn 2018 December, the main-belt asteroid (6478) Gault was reported to display activity. Gault is an asteroid belonging to the Phocaea dynamical family and was not previously known to be active, nor was any other member of the Phocaea family. In this work, we present the results of photometric and spectroscopic observations that commenced soon after the discovery of activity. We obtained observations over two apparitions to monitor its activity, rotation period, composition, and possible non-gravitational orbital evolution. We find that Gault has a rotation period of P = 2.4929 ± 0.0003 h with a light-curve amplitude of 0.06 magnitude. This short rotation period close to the spin barrier limit is consistent with Gault having a density no smaller than ρ = 1.85 g cm−3 and its activity being triggered by the YORP (Yarkovsky–O’Keefe–Radzievskii–Paddack) spin-up mechanism. Analysis of the Gault phase curve over phase angles ranging from 0.4° to 23.6° provides an absolute magnitude of H = 14.81 ± 0.04, G1 = 0.25 ± 0.07, and G2 = 0.38 ± 0.04. Model fits to the phase curve find the surface regolith grain size constrained between 100 and 500 $\rm {\mu }$m. Using relations between the phase curve and albedo, we determine that the geometrical albedo of Gault is pv = 0.26 ± 0.05 corresponding to an equivalent diameter of $D = 2.8^{+0.4}_{-0.2}$ km. Our spectroscopic observations are all consistent with an ordinary chondrite-like composition (S, or Q-type in the Bus-DeMeo taxonomic classification). A search through archival photographic plate surveys found previously unidentified detections of Gault dating back to 1957 and 1958. Only the latter had been digitized, which we measured to nearly double the observation arc of Gault. Finally, we did not find any signal of activity during the 2020 apparition or non-gravitational effects on its orbit.
Pseudo-2D modelling of heat redistribution through H2 thermal dissociation/recombination: consequences for ultra-hot Jupiters
Authors: Roth A , Drummond B , Hébrard E , Tremblin P , Goyal J , Mayne N 
Published: May 2021

ABSTRACT
Thermal dissociation and recombination of molecular hydrogen, H2, in the atmospheres of ultra-hot Jupiters (UHJs) has been shown to play an important role in global heat redistribution. This, in turn, significantly impacts their planetary emission, yet only limited investigations on the atmospheric effects have so far been conducted. Here, we investigate the heat redistribution caused by this dissociation/recombination reaction, alongside feedback mechanisms between the atmospheric chemistry and radiative transfer, for a planetary and stellar configuration typical of UHJs. To do this, we have developed a time-dependent pseudo-2D model, including a treatment of time-independent equilibrium chemical effects. As a result of the reaction heat redistribution, we find temperature changes of up to ∼400 K in the atmosphere. When TiO and VO are additionally considered as opacity sources, these changes in temperature increase to over ∼800 K in some areas. This heat redistribution is found to significantly shift the region of peak atmospheric temperature, or hotspot, towards the evening terminator in both cases. The impact of varying the longitudinal wind speed on the reaction heat redistribution is also investigated. When excluding TiO/VO, increased wind speeds are shown to increase the impact of the reaction heat redistribution up to a threshold wind speed. When including TiO/VO there is no apparent wind speed threshold, due to thermal stabilization by these species. We also construct pseudo-2D phase curves from our model, and highlight both significant spectral flux damping and increased phase offset caused by the reaction heat redistribution.
3D core kinematics of NGC 6362: central rotation in a dynamically evolved globular cluster
Authors: Dalessandro Emanuele , Raso Silvia , Kamann Sebastian , Bellazzini Michele , Vesperini Enrico , Bellini Andrea , Beccari Giacomo 
Published: May 2021

ABSTRACT
We present a detailed 3D kinematic analysis of the central regions (R &lt; 30 arcsec) of the low mass and dynamically evolved galactic globular cluster (GC) NGC 6362. The study is based on data obtained with ESO-VLT/MUSE used in combination with the adaptive optics module and providing ∼3000 line-of-sight radial velocities, which have been complemented with Hubble Space Telescope proper motions. The quality of the data and the number of available radial velocities allowed us to detect for the first time a significant rotation signal along the line of sight in the cluster core with amplitude of ∼1 km s−1 and with a peak located at only ∼20 arcsec from the cluster centre, corresponding to only ${\sim}10{{\ \rm per\ cent}}$ of the cluster half-light radius. This result is further supported by the detection of a central and significant tangential anisotropy in the cluster innermost regions. This is one of the most central rotation signals ever observed in a GC to date. We also explore the rotational properties of the multiple populations hosted by this cluster and find that Na-rich stars rotate about two times more rapidly than the Na-poor sub-population thus suggesting that the interpretation of the present-day GC properties require a multicomponent chemo-dynamical approach. Both the rotation amplitude and peak position would fit qualitatively the theoretical expectations for a system that lost a significant fraction of its original mass because of the long-term dynamical evolution and interaction with the Galaxy. However, to match the observations more quantitatively further theoretical studies to explore the initial dynamical properties of the cluster are needed.
Formation of eccentric gas discs from sublimating or partially disrupted asteroids orbiting white dwarfs
Authors: Trevascus David , Price Daniel J , Nealon Rebecca , Liptai David , Manser Christopher J , Veras Dimitri 
Published: May 2021

ABSTRACT
Of the 21 known gaseous debris discs around white dwarfs, a large fraction of them display observational features that are well described by an eccentric distribution of gas. In the absence of embedded objects or additional forces, these discs should not remain eccentric for long time-scales, and should instead circularize due to viscous spreading. The metal pollution and infrared excess we observe from these stars is consistent with the presence of tidally disrupted sub-stellar bodies. We demonstrate, using smoothed particle hydrodynamics, that a sublimating or partially disrupting planet on an eccentric orbit around a white dwarf will form and maintain a gas disc with an eccentricity within 0.1 of, and lower than, that of the orbiting body. We also demonstrate that the eccentric gas disc observed around the white dwarf SDSS J1228 + 1040 can be explained by the same hypothesis.
Cassette recruitment in the chromosomal Integron of Vibrio cholerae
Authors: Vit Claire , Richard Egill , Fournes Florian , Whiteway Clémence , Eyer Xavier , Lapaillerie Delphine , Parissi Vincent , Mazel Didier , Loot Céline 
Published: May 2021

Abstract
Integrons confer a rapid adaptation capability to bacteria. Integron integrases are able to capture and shuffle novel functions embedded in cassettes. Here, we investigated cassette recruitment in the Vibrio cholerae chromosomal integron during horizontal transfer. We demonstrated that the endogenous integrase expression is sufficiently triggered, after SOS response induction mediated by the entry of cassettes during conjugation and natural transformation, to mediate significant cassette insertions. These insertions preferentially occur at the attIA site, despite the presence of about 180 attC sites in the integron array. Thanks to the presence of a promoter in the attIA site vicinity, all these newly inserted cassettes are expressed and prone to selection. We also showed that the RecA protein is critical for cassette recruitment in the V. cholerae chromosomal integron but not in mobile integrons. Moreover, unlike the mobile integron integrases, that of V. cholerae is not active in other bacteria. Mobile integrons might have evolved from the chromosomal ones by overcoming host factors, explaining their large dissemination in bacteria and their role in antibioresistance expansion.
GalaxyHeteromer: protein heterodimer structure prediction by template-based and ab initio docking
Authors: Park Taeyong , Won Jonghun , Baek Minkyung , Seok Chaok 
Published: May 2021

Abstract
Protein–protein interactions play crucial roles in diverse biological processes, including various disease progressions. Atomistic structural details of protein–protein interactions may provide important information that can facilitate the design of therapeutic agents. GalaxyHeteromer is a freely available automatic web server (http://galaxy.seoklab.org/heteromer) that predicts protein heterodimer complex structures from two subunit protein sequences or structures. When subunit structures are unavailable, they are predicted by template- or distance-prediction-based modelling methods. Heterodimer complex structures can be predicted by both template-based and ab initio docking, depending on the template's availability. Structural templates are detected from the protein structure database based on both the sequence and structure similarities. The templates for heterodimers may be selected from monomer and homo-oligomer structures, as well as from hetero-oligomers, owing to the evolutionary relationships of heterodimers with domains of monomers or subunits of homo-oligomers. In addition, the server employs one of the best ab initio docking methods when heterodimer templates are unavailable. The multiple heterodimer structure models and the associated scores, which are provided by the web server, may be further examined by user to test or develop functional hypotheses or to design new functional molecules.
Hapo-G, haplotype-aware polishing of genome assemblies with accurate reads
Authors: Aury Jean-Marc , Istace Benjamin 
Published: May 2021

Abstract
Single-molecule sequencing technologies have recently been commercialized by Pacific Biosciences and Oxford Nanopore with the promise of sequencing long DNA fragments (kilobases to megabases order) and then, using efficient algorithms, provide high quality assemblies in terms of contiguity and completeness of repetitive regions. However, the error rate of long-read technologies is higher than that of short-read technologies. This has a direct consequence on the base quality of genome assemblies, particularly in coding regions where sequencing errors can disrupt the coding frame of genes. In the case of diploid genomes, the consensus of a given gene can be a mixture between the two haplotypes and can lead to premature stop codons. Several methods have been developed to polish genome assemblies using short reads and generally, they inspect the nucleotide one by one, and provide a correction for each nucleotide of the input assembly. As a result, these algorithms are not able to properly process diploid genomes and they typically switch from one haplotype to another. Herein we proposed Hapo-G (Haplotype-Aware Polishing Of Genomes), a new algorithm capable of incorporating phasing information from high-quality reads (short or long-reads) to polish genome assemblies and in particular assemblies of diploid and heterozygous genomes.
Mineralocorticoid receptor antagonists for nephroprotection and cardioprotection in patients with diabetes mellitus and chronic kidney disease
Authors: Ortiz Alberto , Ferro Charles J , Balafa Olga , Burnier Michel , Ekart Robert , Halimi Jean-Michel , Kreutz Reinhold , Mark Patrick B , Persu Alexandre , Rossignol Patrick , Ruilope Luis M , Schmieder Roland E , Valdivielso Jose M , del Vecchio Lucia , Zoccali Carmine , Mallamaci Francesca , Sarafidis Pantelis ,   for the European Renal and Cardiovascular Medicine (EURECA-m) Working Group of the European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) and the Hypertension and the Kidney Working Group of the European Society of Hypertension (ESH)
Published: May 2021

Abstract
Diabetic kidney disease (DKD) develops in ∼40% of patients with diabetes and is the most common cause of chronic kidney disease (CKD) worldwide. Patients with CKD, especially those with diabetes mellitus, are at high risk of both developing kidney failure and cardiovascular (CV) death. The use of renin–angiotensin system (RAS) blockers to reduce the incidence of kidney failure in patients with DKD dates back to studies that are now ≥20 years old. During the last few years, sodium–glucose co-transporter-2 inhibitors (SGLT2is) have shown beneficial renal effects in randomized trials. However, even in response to combined treatment with RAS blockers and SGLT2is, the renal residual risk remains high with kidney failure only deferred, but not avoided. The risk of CV death also remains high even with optimal current treatment. Steroidal mineralocorticoid receptor antagonists (MRAs) reduce albuminuria and surrogate markers of CV disease in patients already on optimal therapy. However, their use has been curtailed by the significant risk of hyperkalaemia. In the FInerenone in reducing kiDnEy faiLure and dIsease prOgression in DKD (FIDELIO-DKD) study comparing the actions of the non-steroidal MRA finerenone with placebo, finerenone reduced the progression of DKD and the incidence of CV events, with a relatively safe adverse event profile. This document presents in detail the available evidence on the cardioprotective and nephroprotective effects of MRAs, analyses the potential mechanisms involved and discusses their potential future place in the treatment of patients with diabetic CKD.
Allometry of carbon and nitrogen content and growth rate in a diverse range of coccolithophores
Authors: Villiot Naomi , Poulton Alex J , Butcher Elizabeth T , Daniels Lucie R , Coggins Aimee 
Published: May 2021

AbstractAs both photoautotrophs and calcifiers, coccolithophores play important roles in ecosystems and biogeochemical cycles. Though some species form blooms in high-latitude waters, low-latitude communities exhibit high diversity and niche diversification. Despite such diversity, our understanding of the clade relies on knowledge of Emiliana huxleyi. To address this, we examine carbon (C) and nitrogen (N) content of strains (n = 9) from the main families of the calcifying Haptophyceae, as well as allometry and cell size frequency across extant species. Coccolithophore cell size is constrained, with ~71% of 159 species smaller than 10 μm in diameter. Growth rates scale with cell biovolume (μ = 1.83 × cell volume−0.19), with an exponent close to metabolic theory. Organic carbon (C) per cell is lower than for other phytoplankton, providing a coccolithophore-specific relationship between cell organic C content and biovolume (pg C cell−1 = 0.30 × cell volume0.70). Organic C to N ratios (~8.3 mol:mol) are similar to other phytoplankton, implying little additional N cost for calcification and efficient retention and recycling of cell N. Our results support observations that coccolithophores are efficient competitors in low-nutrient conditions, able to photosynthesize, calcify and run the routine metabolic machinery necessary without any additional need for N relative to noncalcifying algae.
An Event-Related Potential Investigation of Early Visual Processing Deficits During Face Perception in Youth at Clinical High Risk for Psychosis
Authors: Osborne K Juston , Kraus Brian , Curran Tim , Earls Holly , Mittal Vijay A 
Published: May 2021

Abstract
Impairments in early visual face perception are well documented in patients with schizophrenia. Specifically, event-related potential (ERP) research in patients with schizophrenia has demonstrated deficits in early sensory processing of stimulus properties (P1 component) and the structural encoding of faces (N170 component). However, it is not well understood if similar impairments are present in individuals at clinical high risk (CHR) for psychosis (ie, those in the putative prodromal stage of the illness). Thus, it is unknown if face perception deficits are the result of illness onset or are present in the high-risk period for the illness. The present study used the ERP technique to examine neural activation when viewing facial emotion expressions and objects in 44 CHR and 47 control adolescents and young adults (N = 91). P1 amplitude was similar across groups, indicating that early sensory processing impairments did not substantially contribute to face perception deficits in CHR youth. CHR youth exhibited reduced N170 amplitude compared to controls when viewing faces but not objects, implicating a specific deficit in the structural encoding of faces rather than a general perceptual deficit. Further, whereas controls demonstrated the expected face-selective N170 effect (ie, larger amplitude for faces than objects), CHR youth did not, which suggests that facial emotion expressions do not elicit the expected preferential perceptual processing for critical social information in individuals at CHR for psychosis. Together, these findings provide valuable information regarding the specific impairments contributing to face perception deficits in the high-risk period where treatment stands to aid in preventing illness progression.
001 Exploring the Orexin-tTA/TetO-DTA Mouse as a Model for Pediatric Narcolepsy
Authors: Joyal Adam , Yamanaka Akihiro , Scammell Thomas , Coffey Alissa 
Published: May 2021

Abstract

Introduction
Narcolepsy is a sleep disorder caused by selective death of the orexin neurons that often begins in childhood. Orexin neuron loss disinhibits REM sleep during the active period and produces cataplexy, an abnormal behavioral state between REM sleep and wakefulness. Cataplexy is often more severe when narcolepsy develops in children compared to adults, but the mechanisms underlying this difference remain unknown.

Methods
We used orexin-tTA/TetO-DTA mice to model narcolepsy at different ages. When doxycycline is removed from the diet, the orexin neurons of these mice express diphtheria toxin A and die within 2–3 weeks. We removed doxycycline at 4 weeks (young-onset) or 14 weeks (adult-onset) of age in male and female mice. We implanted EEG and EMG electrodes for sleep recordings one week later and then recorded EEG/EMG/video for 24h at 3 and 13 weeks after removal of doxycycline. Age-matched controls had access to doxycycline diet for the entire experiment.

Results
Three weeks after doxycycline removal, both young-onset and adult-onset mice developed cataplexy and the sleep-wake fragmentation characteristic of narcolepsy. Age of orexin cell loss did not significantly affect cataplexy severity, however, female mice had more cataplexy than male mice overall. Both young- and adult-onset mice showed a 99% loss of orexin neurons at 3 weeks.

Conclusion
Considered together, our results suggest that the orexin-tTA/TetO-DTA mouse model of narcolepsy does not capture the severe cataplexy that is often seen in the human pediatric population.
Support (if any):
006 The effect of sodium oxybate on cataplexy in orexin knockout mice
Authors: Hamieh Mohamad , Fraigne Jimmy , Peever John 
Published: May 2021

Abstract

Introduction
Narcolepsy is a neurological disorder that is characterized by the loss of orexin neurons in the lateral hypothalamus. Cataplexy is a symptom of narcolepsy and is identified by a sudden loss of muscle tone during wakefulness. Cataplexy abruptly interrupts day-to-day activities, and makes activities like driving dangerous and potentially fatal. It is hypothesized that cataplexy occurs due to the intrusion of REM sleep muscle atonia during wakefulness. It has been demonstrated that a GABAergic mechanism is responsible for silencing the REM sleep atonia circuit and preventing REM sleep muscle atonia from occurring during wakefulness. Sodium oxybate (SXB), a low affinity agonist of GABAB receptors, is currently an approved treatment for narcolepsy; however, its mechanism of action in the brain remains unknown. Here, we investigate the hypothesis that SXB prevents cataplexy through a GABAB mediated mechanism by potentially suppressing the REM sleep atonia circuit.

Methods
We intraperitoneally (IP) injected orexin-/- mice with one of five treatments; either Lactated Ringers Solution, SXB at 50, 100, or 200 mg/kg, or Phaclophen at 10 mg/kg followed by SXB at 100 mg/kg. Cataplexy was assessed by video recordings. We gathered and analyzed data at three distinct chronological time points (i.e, at baseline, after three consecutive weeks of daily dosing with a treatment, and after one week of no treatment). These experiments were designed and conducted to determine whether; 1) SXB reduces cataplexy, 2) the cessation of SXB administration has an effect on cataplexy, 3) SXB is mediated through a GABAB mechanism.

Results
We first confirmed that mice used were indeed orexin-/- using immunohistochemical analysis to show that no orexin-a expressing neurons were located in the lateral hypothalamus. Then, we determined that: 1) SXB reduces cataplexy compared to time matched controls (unpaired t-test, p=0.0027, n=18); 2) When we stopped administering SXB IP injections, cataplexy levels increased towards control levels (paired t-test, p=0.0024, n=18); 3) it remains unclear if SXB’s effect is solely mediated through a GABAB mechanism.

Conclusion
Our findings demonstrate that SXB effectively reduces cataplexy in orexin-/- mice.

Support (if any)
This research was funded by Jazz Pharmaceuticals