bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate change and livestock production: A review
Authors: Agbeja A. O. , Olaifa K. A. , Akindolu D. R. , Salau H. O. , Akinlade M. S. 
Published: March 2021

The livestock system is one of the most important characteristics of agrarian economy; livestock sector provides sustainability and stability to the national economy by contributing to farm energy and food security. Climate change is seen as a major threat to the survival of many species, ecosystems and the sustainability of livestock production systems in many parts of the world. Green house gases (GHG) are released in the atmosphere both by natural sources and anthropogenic (human related) activities. The impact of climate change can heighten the vulnerability of livestock systems and exacerbate existing stresses upon them, such as drought. Parasites and diseases are among the most severe factors that impact livestock production and reproduction, impact on livestock health, impact on feed and fodder availability, reduction in livestock population and impact of climate change on livestock genetics resource. However, the climate change especially global warming may highly influence production performance of farm animals throughout the world, this results in decreased animal production and productivity.

Le système de bétail est l'une des caractéristiques les plus importantes de l'économie agraire; Le secteur de l'élevage assure la durabilité et la stabilité de l'économie nationale en contribuant à l'énergie agricole et à la sécurité alimentaire. Le changement climatique est considéré comme une menace majeure pour la survie de nombreuses espèces, écosystèmes et la durabilité des systèmes de production animale dans de nombreuses régions du monde. Les gaz à effet de serre (GES) sont rejetés dans l'atmosphère à la fois par des sources naturelles et par des activités anthropiques (liées à l'homme). L'impact du changement climatique peut accroître la vulnérabilité des systèmes de bétail et exacerber les tensions existantes sur eux, telles que la sécheresse. Les parasites et les maladies sont parmi les facteurs les plus graves qui ont un impact sur la production et la reproduction du bétail, un impact sur la santé du bétail, un impact sur les aliments et la disponibilité du fourrage, la réduction du cheptel et l'impact du changement climatique sur les ressources génétiques du bétail. Cependant, le changement climatique, en particulier le réchauffement climatique, peut fortement influencer les performances de production des animaux d'élevage à travers le monde, ce qui entraîne une baisse de la production et de la productivité animales.
Inflation dynamics analysis in selected MENA countries
Authors: Kacemi Tarek , Hassan Sallahuddin 
Published: March 2021

The current paper analyses the new Keynesian Phillips curve (NKPC) in the context of selected MENA countries over the 1990-2016 period. This study has used Pooled Mean Group (PMG) and Fully Modified Ordinary Least Square (FMOLS) estimation methods for the empirical analysis. For the dynamic heterogeneous panels, PMG developed by Pesaran et al. (1999) is the most suitable technique. The outcomes by FMOLS asserted that inflation and unemployment are unrelated in the long run, corroborating the long run Philips Curve theory. While, the empirical outcomes obtained by PMG indicate negative linkage between unemployment and inflation in the long run. Nevertheless, the notion of the tradeoff between the inflation and unemployment that expressed by a short-run Phillips curve is not observed in the selected MENA countries. The findings of this study corroborate the hybrid version of NKPC. Moreover, it establishes of the study suggest that the dynamic inflation can be used as a HNKPC model for understanding the inflation behavior in selected MENA countries.
Investigating the Effect of Convenience, Accessibility and Reliability on Customer Satisfaction in the Nigeria Banking Industry
Authors: Abdullahi Mohammed Sani , Usman Bashir Mikail , Salisu Fatima Binta , Muhammad Yusuf Suleiman 
Published: March 2021

This study investigates the effect of convenience, accessibility and reliability on customer satisfaction in the Nigeria banking industry. The target populations of the study are customers of Jaiz Bank, BUK Road Branch in Kano State, Nigeria and the stated bank branch serves as the scope of the study. The population of the study consists of 10,580 customers of the focused bank in question, and 371 respondents make up the study sample size and it was captured out of the stated population which was obtain through research advisors table of sample size determination. Structured questionnaire was employed as the method of data collection, while regression analysis was employed as the method of data analysis that tests the hypothesized hypotheses of the study. The result indicates that electronic accessibility and convenience has significant and positive effect on customer satisfaction. The result of the study also found that electronic reliability has negative effect on customer satisfaction. This study recommends that banks should enlighten and educate customers judiciously on the use of electronic services such as SMS (Mobile) banking, web/internet banking and e-switch, POS banking services that are not well patronized. Internet banking should be well developed in other to face competition in the banking industry and maintain profit.
Some New Identities for the Generalized Fibonacci Polynomials by the Q(x) Matrix
Authors: Chen Chung-Chuan , Huang Lin-Ling 
Published: March 2021

We obtain some new identities for the generalized Fibonacci polynomial by a new approach, namely, the Q(x) matrix.
These identities including the Cassini type identity and Honsberger type formula can be applied to some polynomial
sequences such as Fibonacci polynomials, Lucas polynomials, Pell polynomials, Pell-Lucas polynomials and so on, which
generalize the previous results in references.
Het Skanska-arrest: een mogelijke fundamentele verandering in de civiele handhaving van het Europese mededingingsrecht
Authors: Bothof S.W. 
Published: March 2021

Het Skanska-arrest: een mogelijke fundamentele verandering in de civiele handhaving van het Europese mededingingsrecht
In deze bijdrage analyseert de auteur de gevolgen van het Skanska-arrest in een schadeprocedure voor overtreding van het Europese mededingingsrecht. Op grond van de jurisprudentie en literatuur concludeert de auteur dat de doorwerking van het ondernemingsbegrip, als gevolg van het Skanska-arrest, de benadeelde een significante uitbreiding van aansprakelijkheidsmogelijkheden kan bieden.
Nikola Tesla en de coltrui-CEO: de gevaren van informatiemanipulatie
Authors: Giltjes M.J. 
Published: March 2021

Nikola Tesla en de coltrui-CEO: de gevaren van informatiemanipulatie. Vertrouwen van het beleggend of het algemeen publiek?
De auteur betoogt dat met de doelstellingen achter het informatiemanipulatieverbod van de Marktmisbruikverordening wordt beoogd het vertrouwen van het algemeen publiek, in tegenstelling tot slechts het vertrouwen van het beleggend publiek, te waarborgen. Een helder begrip van deze doelstellingen is noodzakelijk voor de effectieve handhaving van het informatiemanipulatieverbod.
A influência da ansiedade na compulsão alimentar e na obesidade de universitários
Authors: Munhoz Paula Gulart , Borges Gustavo Da Rosa , Beuron Thiago Antônio , Petry Jonas Fernando 
Published: March 2021

Altos níveis de ansiedade são considerados um fenômeno que, infelizmente, está presente na vida de muitas pessoas. Estes elevados índices de ansiedade podem causar distúrbios tais como a compulsão alimentar e a obesidade. Este estudo tem como objetivo verificar se a ansiedade influencia na compulsão alimentar e na obesidade de alunos da Universidade Federal do Pampa (Campus Dom Pedrito). Usando um conjunto de dados coletados por um survey com 373 acadêmicos da universidade UNIPAMPA. Uma abordagem de regressão é empregada para estudar o impacto das variáveis latentes associadas à compulsão alimentar e a obesidade. Os resultados indicam que a ansiedade pode ter influência na compulsão alimentar. Por outro lado, observou-se que a ansiedade não provoca a obesidade. Os resultados mostram que a compulsão alimentar influencia na obesidade. Além disso, presupõe-se que a compulsão alimentar pode ser uma variável mediadora na relação entre a ansiedade e a obesidade.
The Impact of Increasing Disease Prevalence, False Omissions, and Diagnostic Uncertainty on Coronavirus Disease 2019 (COVID-19) Test Performance
Authors: Kost Gerald J. 
Published: March 2021

Context.—
Coronavirus disease 2019 (COVID-19) test performance depends on predictive values in settings of increasing disease prevalence. Geospatially distributed diagnostics with minimal uncertainty facilitate efficient point-of-need strategies.

Objectives.—
To use original mathematics to interpret COVID-19 test metrics; assess US Food and Drug Administration Emergency Use Authorizations and Health Canada targets; compare predictive values for multiplex, antigen, polymerase chain reaction kit, point-of-care antibody, and home tests; enhance test performance; and improve decision-making.

Design.—
PubMed/newsprint-generated articles documenting prevalence. Mathematica and open access software helped perform recursive calculations, graph multivariate relationships, and visualize performance by comparing predictive value geometric mean-squared patterns.

Results.—
Tiered sensitivity/specificity comprised: T1, 90%, 95%; T2, 95%, 97.5%; and T3, 100%, ≥99%. Tier 1 false negatives exceeded true negatives at &gt;90.5% prevalence; false positives exceeded true positives at &lt;5.3% prevalence. High-sensitivity/specificity tests reduced false negatives and false positives, yielding superior predictive values. Recursive testing improved predictive values. Visual logistics facilitated test comparisons. Antigen test quality fell off as prevalence increased. Multiplex severe acute respiratory syndrome (SARS)–CoV-2)*influenza A/B*respiratory syncytial virus testing performed reasonably well compared with tier 3. Tier 3 performance with a tier 2 confidence band lower limit will generate excellent performance and reliability.

Conclusions.—
The overriding principle is to select the best combined performance and reliability pattern for the prevalence bracket. Some public health professionals recommend repetitive testing to compensate for low sensitivity. More logically, improved COVID-19 assays with less uncertainty conserve resources. Multiplex differentiation of COVID-19 from influenza A/B–respiratory syncytial virus represents an effective strategy if seasonal flu surges next year.
Betanin and Allicin Ameliorate Adriamycin-Induced Cardiotoxicity in Rats by Ameliorating Cardiac Ischemia and Improving Antioxidant Efficiency
Authors: Al-Thubiani W. S. , Abuzinadah O. A. H. , El-Aziz G. S. Abd 
Published: March 2021

Aims: To investigate the protective effects of betanin and allicin against adriamycin (ADR)-induced cardiotoxicity.
Study Design: Experimental animal model.
Place and Duration of Study: King Abdul-Aziz University, Jeddah, Saudi Arabia; 10 days.
Methodology: Adult female Wistar rats were allocated to the following groups (n = 10 per group): Control, received water, a standard diet for 10 days and i.p normal saline on day 8; ADR, intraperitoneal injection with 15 mg/kg ADR as a single dose on day 8; ADR+BE, betanin (20 mg/kg) administration followed by i.p. injection of ADR (15 mg/kg); ADR+ALL, allicin (20 mg/kg) administration followed by i.p. injection of ADR; and ADR+BE+ALL, equal volumes of betanin and allicin followed by ADR (15 mg/kg). Hemodynamic characteristics of the cardiovascular system and electrocardiography were evaluated. Blood samples were obtained to assess cardiac enzymes; cardiac homogenates were processed to analyze oxidative and antioxidant parameters and low-grade inflammatory indicators. Histopathological evaluation of heart tissues was also conducted.
Results: Rats pre-administered betanin and allicin were protected from ADR-associated ischemia based on the significant (P < .05) shortening of QT, QTC interval, QRS, and T peak Tend interval compared with the ADR group. Betanin and allicin pre-treatment significantly decreased the ADR-induced elevated serum creatine kinase-MB and lactate dehydrogenase levels. ADR-elevated cardiac oxidative parameters, along with the serum concentrations of the tumor necrosis factor-alpha and the cardiac transforming growth factor-beta, were significantly inhibited by betanin and allicin. Histopathological findings confirmed the biochemical results. Betanin and allicin reduced ADR-induced heart damage by inhibiting several pathways, including those of oxidative stress and inflammation.
Conclusion: Betanin and allicin may be promising cardioprotective agents owing to their antioxidant and cytoprotective properties and could thus be used as adjuvant treatment for cancer therapy.
Stress Response and Nutrient Homeostasis in Lettuce (Lactuca sativa) Exposed to Graphene Quantum Dots Are Modulated by Particle Surface Functionalization
Authors: Zhang Peng , Wu Xinyue , Guo Zhiling , Yang Xiaonan , Hu Xiangang , Lynch Iseult 
Published: March 2021

AbstractA 5‐d germination assay and a 14‐d hydroponic trial are performed to evaluate the impacts of graphene quantum dots (GQDs) on lettuce. Results show that GQDs are toxic to lettuce plants and that the effects are highly dependent on particle surface functionalization and plant growth stage. The germination rate is not affected by aminated GQDs (N‐GQDs) and carboxylated GQDs (C‐GQDs) but is reduced by hydroxylated GQDs (O‐GQDs) by 39–71%. During the hydroponic trial, N‐GQDs (50 mg L−1) increase the root dry weight by 34%, while C‐GQDs and O‐GQDs reduce it by 39% and 43%, respectively. Shoot dry weight is not affected by N‐GQDs but is reduced by C‐GQDs (44%) and O‐GQDs (36–55%) treatments. C‐GQDs and O‐GQDs cause oxidative damage, disruption of mineral and organic nutrients homeostasis, impairment of photosynthesis, and modulates the levels of phytohormones. Light‐triggered reactive oxygen species generation and oxidation of antioxidants in plants are the critical reason for the phytotoxicity and explain the difference between the different functionalizations. These findings suggest that GQDs may not be as safe as expected. Future studies should consider the modulation of surface chemistry to achieve optimal safety of GQDs, and more plant species should be tested over a longer‐term scale.
3D Printing of Transparent Spinel Ceramics with Transmittance Approaching the Theoretical Limit
Authors: Wang Haomin , Liu Li Ying , Ye Pengcheng , Huang Zhangyi , Ng Andrew Yun Ru , Du Zehui , Dong Zhili , Tang Dingyuan , Gan Chee Lip 
Published: March 2021

Abstract3D printing of transparent ceramics has attracted great attention recently but faces the challenges of low transparency and low printing resolution. Herein, magnesium aluminate spinel transparent ceramics with transmittance reaching 97% of the theoretical limit are successfully fabricated using a stereolithography‐based 3D printing method assisted by hot isostatic pressing and the critical factors governing the transparency are revealed. Various transparent spinel lenses and microlattices are printed at a high resolution of ≈100–200 µm. The 3D printed spinel lens demonstrates fairly good optical imaging ability, and the printed spinel diamond microlattices as a transparent photocatalyst support for TiO2 significantly enhance its photocatalytic efficiency compared with its opaque counterparts. Compared with other 3D printed transparent materials such as silica glass or organic polymers, the printed spinel ceramics have the advantages of broad optical window, high hardness, excellent high‐temperature stability, and chemical resistance and therefore, have great potential to be used in various optical lenses/windows and photocatalyst supports for application in harsh environments.
Analogue Optical Spatiotemporal Differentiator
Authors: Zhou Yi , Zhan Junjie , Chen Rui , Chen Wenjie , Wang Yubo , Shao Yifan , Ma Yungui 
Published: March 2021

AbstractAs a significant part in optical computation, analogue optical spatial/temporal differentiators could play a great role in all‐optical signal processing, feature extraction, and optical storage. In the past few years, they have experienced rapid development but mostly for a single function. For many scenarios, optical computation with integrated functionalities is highly desired. In this work, an analogue optical spatiotemporal differentiator utilizing all‐dielectric multilayer is proposed. The film stack is specifically engineered to satisfy the requirements for both spatial and temporal transfer functions of the ideal differentiator. The time‐space performance of the device is numerically examined from the output field profile of the classical Gaussian beam or pulse. A wavelength‐scale high resolution for edge detection is attained using the integrated differentiator. This work may pave a potential way to establish ultracompact, high‐bandwidth, and real‐time optical multiple functional computation systems.
A Combined Model of Human iPSC‐Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome
Authors: Guo Jingyi , Duan Lifan , He Xueying , Li Shengbiao , Wu Yi , Xiang Ge , Bao Feixiang , Yang Liang , Shi Hongyan , Gao Mi , Zheng Lingjun , Hu Huili , Liu Xingguo 
Published: March 2021

AbstractMitochondrial DNA depletion syndrome (MDS) is a group of severe inherited disorders caused by mutations in genes, such as deoxyribonucleoside kinase (DGUOK). A great majority of DGUOK mutant MDS patients develop iron overload progressing to severe liver failure. However, the pathological mechanisms connecting iron overload and hepatic damage remains uncovered. Here, two patients’ skin fibroblasts are reprogrammed to induced pluripotent stem cells (iPSCs) and then corrected by CRISPR/Cas9. Patient‐specific iPSCs and corrected iPSCs‐derived high purity hepatocyte organoids (iHep‐Orgs) and hepatocyte‐like cells (iHep) are generated as cellular models for studying hepatic pathology. DGUOK mutant iHep and iHep‐Orgs, but not control and corrected one, are more sensitive to iron overload‐induced ferroptosis, which can be rescued by N‐Acetylcysteine (NAC). Mechanically, this ferroptosis is a process mediated by nuclear receptor co‐activator 4 (NCOA4)‐dependent degradation of ferritin in lysosome and cellular labile iron release. This study reveals the underlying pathological mechanisms and the viable therapeutic strategies of this syndrome, and is the first pure iHep‐Orgs model in hereditary liver diseases.
DeepVISP: Deep Learning for Virus Site Integration Prediction and Motif Discovery
Authors: Xu Haodong , Jia Peilin , Zhao Zhongming 
Published: March 2021

AbstractApproximately 15% of human cancers are estimated to be attributed to viruses. Virus sequences can be integrated into the host genome, leading to genomic instability and carcinogenesis. Here, a new deep convolutional neural network (CNN) model is developed with attention architecture, namely DeepVISP, for accurately predicting oncogenic virus integration sites (VISs) in the human genome. Using the curated benchmark integration data of three viruses, hepatitis B virus (HBV), human herpesvirus (HPV), and Epstein‐Barr virus (EBV), DeepVISP achieves high accuracy and robust performance for all three viruses through automatically learning informative features and essential genomic positions only from the DNA sequences. In comparison, DeepVISP outperforms conventional machine learning methods by 8.43–34.33% measured by area under curve (AUC) value enhancement in three viruses. Moreover, DeepVISP can decode cis‐regulatory factors that are potentially involved in virus integration and tumorigenesis, such as HOXB7, IKZF1, and LHX6. These findings are supported by multiple lines of evidence in literature. The clustering analysis of the informative motifs reveales that the representative k‐mers in clusters could help guide virus recognition of the host genes. A user‐friendly web server is developed for predicting putative oncogenic VISs in the human genome using DeepVISP.
Influence of agronomic and kernel‐related properties on popping expansion in popcorn
Authors: Saito Marcelo Akira , Alves Alex Viana , Kuritza Danilo de Paula , de Souza Yure Pequeno , Maioli Maria Fernanda de Souza Dias , Amaral Júnior Antônio Teixeira do , Bento Antônio Carlos , Scapim Carlos Alberto , Pinto Ronald José Barth 
Published: March 2021

AbstractKnowledge about relationships between traits can contribute to raising the efficiency of selection of superior genotypes. The objective of this study was to estimate the correlations, direct and indirect effects of agronomic, chemical and physical traits of kernels on popping expansion (PE) in popcorn (Zea mays L.). The trial was carried out in the 2017/2018 growing season, in Maringá ‐ PR, with 49 treatments, which consisted of 43 popcorn, four flint, and two sweet corn. The trial was arranged in a randomized complete block design with three replications. Multiple agronomic, chemical, physical, and popcorn quality traits were evaluated. Analysis of variance was performed to estimate the coefficients of phenotypic and genotypic correlations and the direct and indirect effects of path analysis. The genotypes were partitioned into genotype within each kernel type (popcorn, flint, and sweet corn) and two more contrasts (popcorn vs. [flint + sweet corn]) and flint vs. sweet corn. Positive phenotypic (.76) and genotypic correlations (.81) between popping expansion and pericarp thickness were detected. Kernel length had negative phenotypic (−.75) and genotypic correlations (−.78) with PE. Path analysis indicated that pericarp thickness has a direct and positive effect on PE and that the observed positive correlation with thermal diffusivity of the kernel pericarp and kernel length can be explained by indirect effects of the pericarp thickness. Evaluating kernel length may be most prudent considering economical and practical constraints to popcorn breeding programs.
Design, synthesis, and biological evaluation of 1,2,4‐oxadiazole‐containing pyrazolo[3,4‐b]pyridinones as a new series of AMPKɑ1β1γ1 activators
Authors: Xiao Zhihong , Peng Yajun , Zheng Bifeng , Chang Qi , Guo Yating , Chen Zhuo , Li Qianbin , Hu Gaoyun 
Published: March 2021

AbstractAdenosine monophosphate‐activated protein kinase (AMPK) plays a key role in maintaining whole‐body homeostasis and has been regarded as a therapeutic target for the treatment of diabetic nephropathy (DN). Herein, a series of 1,2,4‐oxadiazole‐containing pyrazolo[3,4‐b]pyridinone derivatives is reported as AMPKɑ1β1γ1 activators. The in vitro biological assay demonstrated that compounds 12k (EC50[AMPKα1γ1β1] = 180 nM) and 13q (EC50[AMPKα1γ1β1] = 2 nM) displayed significant enzyme activation. Mechanism studies indicated that both compounds reduced the levels of reactive oxygen species in a rat kidney fibroblast cell line (NRK‐49F) stimulated by transforming growth factor‐β and induced early apoptosis of NRK‐49F cells at 10 μM. Molecular docking studies suggested that 13q exhibited critical hydrogen‐bond interactions with the critical amino acid residues Lys29, Lys31, Asn111, and Asp88 at the binding site of the AMPK protein. These results enrich the structure pool of AMPK activators and provide novel lead compounds for the subsequent development of compounds with a promising therapeutic potential against DN.