bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole-genome sequencing with long reads reveals complex structure and origin of structural variation in human genetic variations and somatic mutations in cancer
Authors: Fujimoto Akihiro , Wong Jing Hao , Yoshii Yukiko , Akiyama Shintaro , Tanaka Azusa , Yagi Hitomi , Shigemizu Daichi , Nakagawa Hidewaki , Mizokami Masashi , Shimada Mihoko 
Published: April 2021

AbstractBackgroundIdentification of germline variation and somatic mutations is a major issue in human genetics. However, due to the limitations of DNA sequencing technologies and computational algorithms, our understanding of genetic variation and somatic mutations is far from complete.MethodsIn the present study, we performed whole-genome sequencing using long-read sequencing technology (Oxford Nanopore) for 11 Japanese liver cancers and matched normal samples which were previously sequenced for the International Cancer Genome Consortium (ICGC). We constructed an analysis pipeline for the long-read data and identified germline and somatic structural variations (SVs).ResultsIn polymorphic germline SVs, our analysis identified 8004 insertions, 6389 deletions, 27 inversions, and 32 intra-chromosomal translocations. By comparing to the chimpanzee genome, we correctly inferred events that caused insertions and deletions and found that most insertions were caused by transposons andAluis the most predominant source, while other types of insertions, such as tandem duplications and processed pseudogenes, are rare. We inferred mechanisms of deletion generations and found that most non-allelic homolog recombination (NAHR) events were caused by recombination errors in SINEs. Analysis of somatic mutations in liver cancers showed that long reads could detect larger numbers of SVs than a previous short-read study and that mechanisms of cancer SV generation were different from that of germline deletions.ConclusionsOur analysis provides a comprehensive catalog of polymorphic and somatic SVs, as well as their possible causes. Our software are available athttps://github.com/afujimoto/CAMPHORandhttps://github.com/afujimoto/CAMPHORsomatic.
Predictive value of small dense low-density lipoprotein cholesterol for cardiovascular events in Chinese elder diabetes mellitus patients
Authors: Xu Li , Chen Xu , Lu Jingfen , Xu Yan , Yang Honglin , Zhou Xuewen , Zhou Jun , Xu Jianhong , Shen Hao 
Published: April 2021

Abstract
Background
As a subcomponent of low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (sdLDL-C) has been suggested to be a better predictor of cardiovascular diseases (CVD). The aim of this research was to evaluate the predictive value of the sdLDL-C in cardiovascular events (CVs) in Chinese elderly patients with type 2 diabetes mellitus (DM).

Methods
A total of 386 consecutive type 2 DM patients were included into this study during December 2014 to December 2016. The serum sdLDL-C level of each subject was measured by homogeneous method. During a period of 48-month’s follow-up, the occurrence of CVs and associated clinical information were recorded. Receiver operating characteristic (ROC) curves were used to assess the predictive value of serum sdLDL-C to occurrence of major CVs.

Results
A total of 92 CVs occurred during the study period. The ROC curve analysis manifested that sdLDL-C in the study population had a matchable discriminatory power (AUC for sdLDL-C was 0.7366, P = 0.003). In addition, Kaplan-Meier event-free survival curves displayed an obvious increase of CVs risk for sdLDL‐C ≧ 26 mg/dL (log-rank = 9.10, P = 0.003). This phenomenon had analogous results in patients who received statins at baseline (log rank = 7.336, P = 0.007). Cox regression analysis revealed that the increase in HbA1c, glucose, LDL-C, sdLDL-C, non-high-density lipoprotein cholesterol (non-HDL-C) and apolipoprotein B (ApoB) and the decrease in apolipoprotein AI (ApoAI) were obviously interrelated with heightened CVs risk. Multiple Cox regression demonstrated that the increase of sdLDL-C and hemoglobin A1c (HbA1c) was significantly correlated with CVs. The results of the study indicated that high sdLDL-C level (> 10 mg/dL) was a risk factor for CVs in the multivariate model (HR 1.281, 95% CI 1.225–16.032; P < 0.01).

Conclusion
sdLDL-C level could be an effective predictor in predicting the future CVs for Chinese elderly patients with type 2 DM and dyslipidemia.
Cardiac regeneration in the axolotl is unaffected by alterations in leukocyte numbers induced by lipopolysaccharide and prednisolone
Authors: Pedersen Kathrine , Rasmussen Rikke Kongsgaard , Dittrich Anita , Lauridsen Henrik 
Published: April 2021

Abstract
Objective
Cardiac regeneration in the axolotl has been found to rely on the innate immune system, and especially macrophages have been demonstrated to play a vital role in regulating the regenerative process. In this study we wanted to induce a pro- and anti-inflammatory milieu in the axolotl during heart regeneration to test the resilience of the regenerative response.

Results
This was induced via repeated intrapericardial injections of lipopolysaccharide or prednisolone during a 40-day regeneration period in order to challenge the presumably fine-tuned inflammatory response that normally facilitates regeneration. We observed a local and systemic leucocyte response to pro- and anti-inflammatory stimulation, but we found cardiac regeneration to be structurally and functionally unaffected.
The relationship between opioid agonist therapy satisfaction and fentanyl exposure in a Canadian setting
Authors: Mackay Lindsay , Kerr Thomas , Fairbairn Nadia , Grant Cameron , Milloy M.-J. , Hayashi Kanna 
Published: April 2021

Abstract
Background
While patient-reported treatment dissatisfaction is considered an important factor in determining the success of substance use disorder treatment, the levels of dissatisfaction with opioid agonist therapies (OAT) and its relationship with the risk of fentanyl exposure have not been characterized in the context of the ongoing opioid overdose crisis in the US and Canada. Our primary hypothesis was that OAT dissatisfaction was associated with an increased odds of fentanyl exposure.

Methods
Our objective was to examine self-reported treatment satisfaction among OAT patients in Vancouver, Canada and the association with fentanyl exposure. Longitudinal data were derived from 804 participants on OAT enrolled in two community-recruited harmonized prospective cohort studies of people who use drugs in Vancouver between 2016 and 2018 via semi-annual interviews and urine drug screens (UDS). We employed multivariable generalized estimating equations to examine the relationship between OAT dissatisfaction and fentanyl exposure.

Results
Out of 804 participants (57.0% male), 222 (27.6%) reported being dissatisfied with OAT at baseline and 1070 out of 1930 observations (55.4%) had fentanyl exposure. The distribution of OAT reported in the sample was methadone (n = 692, 77.7%), buprenorphine-naloxone (n = 82, 9.2%), injectable OAT (i.e., diacetylmorphine or hydromorphone; (n = 65, 7.3%), slow-release oral morphine (n = 44, 4.9%) and other/study medication (n = 8, 1.0%). In the multivariable analysis, OAT dissatisfaction was positively associated with fentanyl exposure (AOR = 1.34; 95% CI: 1.08–1.66).

Conclusions
A substantial proportion of OAT patients in our sample reported dissatisfaction with their OAT, and more than half were exposed to fentanyl. We also found that those who were dissatisfied with their OAT were more likely to be exposed to fentanyl. These findings demonstrate the importance of optimizing OAT satisfaction in the context of the ongoing opioid overdose crisis.
Locally available agroresidues as potential sorbents: modelling, column studies and scale-up
Authors: Shah Arth Jayesh , Soni Bhavin , Karmee Sanjib Kumar 
Published: April 2021

AbstractSawdust, cotton stalk and groundnut shell were used for removal of methylene blue from aqueous solution using batch sorption. Effect of initial dye concentration, temperature, and particle size of sorbents on methylene blue removal was investigated. Sorption capacity increases with rise in initial dye concentration and temperature. Impact of particle size on sorption of methylene blue was investigated and indicated that removal of dye increases with decrease in particle size of sorbents. Maximum sorption for sawdust, cotton stalks and groundnut shell were 9.22 mg g−1, 8.37 mg g−1 and 8.20 mg g−1 respectively; at 60 °C and 100 ppm initial dye concentration. Sorption isotherms were analyzed using fundamental Freundlich isotherm. Subsequently, sips isotherm model was employed for better fitting. Kinetic study shows that, biosorption process is pseudo-second-order in nature. During the course of this study, adsorption dynamics revealed that film diffusion was key step for biosorption. In addition, thermodynamics of sorption was studied; and it was found that Gibbs free energy (∆G°) decreases with increase in temperature. Sawdust was found to be best among all the sorbents. Therefore, column studies and breakthrough curve modelling were performed using sawdust. Furthermore, it was estimated that a scaled-up column using sawdust can treat 6672 L of wastewater in 24 h with 80% efficiency.
Thoracic endovascular aortic repair for recurrent stroke due to atheromatic plaque in the proximal descending aorta: a case report
Authors: Hashimoto Masafumi , Nakano Yoshikazu , Tamura Yusaku 
Published: April 2021

Abstract
Background
Diastolic retrograde flow in the descending aorta (DAo) may occur in the presence of atherosclerosis and may be overlooked as a mechanism of retrograde embolization in patients with stroke. We performed thoracic endovascular aortic repair (TEVAR) in a patient with recurrent cerebral infarctions for treatment of aortic aneurysm with atheromatic plaque, which was considered as the source of embolism.

Case presentation
A 56-year-old man with a history of idiopathic thrombocytopenia and hypertension was referred to our hospital with paralysis of the right upper and lower limbs. Multiple cerebral infarctions were found and treated; however, 1 month later, another cerebral infarction developed. A small saccular aortic aneurysm with plaque was found beyond the left subclavian artery, and this site was deemed as the source of embolism. We performed TEVAR to prevent further recurrence of cerebral infarctions. No cerebral infarctions were observed 6 months post-operation.

Conclusions
TEVAR is a useful treatment for not only aortic aneurysm and dissection, but also cerebral infarctions caused by an embolic source proximal to the DAo due to retrograde aortic blood flow.
Evolution of Physical Demands of Australian Football League Matches from 2005 to 2017: A Systematic Review and Meta-Regression
Authors: Janetzki Samuel J. , Bourdon Pitre C. , Norton Kevin I. , Lane Jackson C. , Bellenger Clint R. 
Published: April 2021

Abstract
Background
There is extensive research investigating the match demands of players in the Australian Football League (AFL).

Objective
This systematic literature review and meta-regression sought to analyse the evolution of in-game demands in AFL matches from 2005 to 2017, focusing on the relationship between volume and intensity.

Methods
A systematic search of Ovid MEDLINE, Embase, Emcare, Scopus, SPORTDiscus, and Cochrane Library databases was conducted. Included studies examined the physical demands of AFL matches utilising global positioning system (GPS) technology. Meta-regression analysed the shift in reported volume (total distance and total match time) and intensity (metres per minute [m.min−1], sprint duration and acceleration) metrics for overall changes, across quarters and positional groups (forwards, nomadics and defenders) from 2005 to 2017 inclusive and for each year between 2005 and 2007, 2007 and 2010, 2010 and 2012, and 2012 and 2015/2017 breakpoints.

Results
Distance (p = 0.094), m.min−1 (p = 0.494), match time (p = 0.591), time over 18 km·h−1 (p = 0.271), and number of accelerations greater than 4 km·h−1 (p = 0.498) and 10 km·h−1 (p = 0.335) in 1 s did not change from 2005 to 2017. From 2005 to 2007 volume decreased (− 6.10 min of match time; p = 0.010) and intensity increased (6.8 m.min−1 increase; p = 0.023). Volume and intensity increased from 2007 to 2010, evidenced by increases in total distance (302 m; p = 0.039), time over 18 km·h−1 (0.31 min; p = 0.005), and number of accelerations greater than 4 km·h−1 (41.1; p = 0.004) and 10 km·h−1 (3.6; p = 0.005) in 1 s. From 2010 to 2012, intensity decreased, evidenced by reductions in metres per minute (− 4.3; p = 0.022), time over 18 km·h−1 (− 0.93 min; p < 0.001), and number of accelerations greater than 4 km·h−1 (− 104.4; p < 0.001) and 10 km·h−1 (− 8.3; p < 0.001) in 1 s, whilst volume stabilised with no changes in distance (p = 0.068) and match time (p = 0.443). From 2012 to 2015/2017 volume remained stable and intensity increased with time over 18 km·h−1 (0.27 min; p = 0.008) and number of accelerations greater than 4 km·h−1 (31.6; p = 0.016) in 1 s increasing.

Conclusions
Changes in volume and intensity of AFL match demands are defined by discrete periods from 2007 to 2010 and 2010 to 2012. The interaction of rule and interpretation changes and coaching strategies play a major role in these evolutionary changes. In turn, modified game styles impact player game demands, training, and selection priorities. Standardisation and uniformity of GPS data reporting is recommended due to inconsistencies in the literature.
Economic self-reliance or social relations? What works in refugee integration? Learning from resettlement programmes in Japan and the UK
Authors: Phillimore Jenny , Morrice Linda , Kabe Kunihiko , Hashimoto Naoko , Hassan Sara , Reyes Marisol 
Published: April 2021

AbstractThere is an urgent need to expand the scale and scope of refugee resettlement schemes, and yet country approaches to resettlement vary markedly and there is little cross-country learning from approaches and refugee experiences. In Japan, resettlement focuses on economic self-sufficiency through employment; whereas the UK, through Community Sponsorship volunteers, on providing social connections to facilitate integration. This paper explores the strengths and short-comings of each approach and examines the ways in which refugee resettlement programmes prioritising different integration domains might influence refugee experiences of integration more widely. Drawing on principles and domains set out in the Indicators of Integration Framework (Ndofor-Tah, C. Strang, A. Phillimore, J. Morrice, L., Michael, L., Wood, P., Simmons, J. (2019) Home Office Indicators of Integration framework 2019), insight is provided into the multi-dimensionality of integration and new understandings about the nature of social connections are offered. The findings highlight the context specific nature of integration policy and practice and underline the importance of a holistic approach. We conclude that resettlement initiatives might incorporate both employers and local communities working in collaboration to support newly arrived refugees but with some state involvement.
Cutaneous anthrax outbreak associated with handling dead animals, Rhino Camp sub-county: Arua District, Uganda, January–May 2018
Authors: Ntono Vivian , Eurien Daniel , Bulage Lilian , Kadobera Daniel , Harris Julie , Ario Alex Riolexus 
Published: April 2021

Abstract
Background
On 18 January 2018 a 40 year old man presented with skin lesions at Rhino Camp Health Centre. A skin lesion swab was collected on 20 January 2018 and was confirmed by PCR at Uganda Virus Research Institute on 21 January 2018. Subsequently, about 9 persons were reported to have fallen ill after reporting contact with livestock that died suddenly. On 9 February 2018, Arua District notified Uganda Ministry of Health of a confirmed anthrax outbreak among humans in Rhino Camp sub-county. We investigated to determine the scope and mode of transmission and exposures associated with identified anthrax to guide control and prevention measures.

Methods
We defined a suspected cutaneous anthrax case as onset of skin lesions (e.g., papule, vesicle, or eschar) in a person residing in Rhino Camp sub-county, Arua District from 25 December 2017 to 31 May 2018. A confirmed case was a suspected case with PCR-positivity for Bacillus anthracis from a clinical sample. We identified cases by reviewing medical records at Rhino Camp Health Centre. We also conducted additional case searches in the affected community with support from Community Health Workers. In a retrospective cohort study, we interviewed all members of households in which at least one person had contact with the carcasses of or meat from animals suspected to have died of anthrax. We collected and tested hides of implicated animals using an anthrax rapid diagnostic test.

Results
We identified 14 case-patients (1 confirmed, 13 suspected); none died. Only males were affected (affected proportion: 12/10,000). Mean age of case-persons was 33 years (SD: 22). The outbreak lasted for 5 months, from January 2018–May 2018, peaking in February. Skinning (risk ratio = 2.7, 95% CI = 1.1–6.7), dissecting (RR = 3.0, 95% CI = 1.2–7.6), and carrying dead animals (RR = 2.7, 95% CI = 1.1–6.7) were associated with increased risk of illness, as were carrying dissected parts of animals (RR = 2.9, 95% CI 1.3–6.5) and preparing and cooking the meat (RR = 2.3, 95% CI 0.9–5.9). We found evidence of animal remains on pastureland.

Conclusion
Multiple exposures to the hides and meat of animals that died suddenly were associated with this cutaneous anthrax outbreak in Arua District. We recommended public education about safe disposal of carcasses of livestock that die suddenly.
ANALISIS PENGARUH INVESTASI, LIKUIDITAS, PROFITABILITAS, UKURAN PERUSAHAAN, DAN PERTUMBUHAN PERUSAHAAN TERHADAP DIVIDEN PAYOUT RATIO PADA PERUSAHAAN SEKTOR INDUSTRI BARANG KONSUMSI YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Dewi Marlindasari , Sulistiyani Tina 
Published: April 2021

This research is aimed to test five independent variables of Investments (Total Assets), Liquidity (Current Ratio, Profitability (Return On Assets), Corporate Size (Size) and Corporate Growth (Growth) wich are estimated to affect the dependent variables i.e. Dividend Payout Ratio of companies in consumer goods industrial sector listed on Indonesia Stock Exchange (IDX) in the year 2009-2012. The population in this research was the companies in consumer goods industrial sector listed on Indonesia Stock Exchange (IDX) in the year 2009-2012. The method in this research used purposive sampling. From the population of 38 companies, those became samples were 14 companies only. The analytical tool used was multipled linier regressions by using T-test (partially). The result of this research with = 5%, partially shows that the independent variables of Liquidity (CR), Corporate Size (Size), Corporate Growth (Growth) significantly affect the Dividend Payout Ratio where the significance value is smaller than = 5%, while the variables of Investment (TA) and Probability (ROA) do not have significant effect on Dividend Payout Ratio where the significance value is greater than =5%.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI MINAT BELI KONSUMEN PADA SITUS JUAL-BELI ONLINE
Authors: Setiawan I Gede Andri , Sukardi Sukardi 
Published: April 2021

The purpose of this study were to analyze (1) the influence of trust of the purchase interest of online shop consumers, (2) the influence of risk perception of the purchase interest of online shop consumers, (3) the influence of use fulness perception of the purchase interest of online shop consumers, (4) the influence of price perception of the purchase interest of online shop consumers. The populations in this research are student of Ahmad Dahlah University Yogyakarta Campus One. The method sample is purposif sampling with the number of sample as much as 100 respondents from three Faculty that is, Economy Faculty, Psycology Faculty, and FTDI. Collecting data using questionnaires that was done validity test and realibity test. This research was done by using multiple linear regression data analysis. The results of this study indicate that (1) the trust is not significant influence on consumer purchase interest of the sites online shop, this is evidenced by the significant value is bigger than the probability alpha value of 0.05 (0,206 > 0.05), and the regression coefficient has a positive value of 0.062; (2) the trust is not significant influence on consumer purchase interest of the sites online shop, this is evidenced by the significant value is bigger than the probability alpha value of 0.05 (0, 0,234 > 0.05), and the regression coefficient has a positive value of 0.057; (3) the usefulness perception is significant influence on consumer purchase interest of the sites online shop, this is evidenced by the significant value is smaller than the probability alpha value of 0.05 (0.000 < 0.05), and the regression coefficients has a positive value of 0.456; (4) the price perception is not significant influence on consumer purchase interest of the sites online shop, this is evidenced by the significant value is bigger than the probability alpha value of 0.05 (0.066 > 0.05), and the regression coefficient has a positive value of 0.111; and (5) trust, risk perception, usefulness perception and price perception together have an effect on consumer purchase interest of the sites online shop, this is evidenced by the significant value is smaller than the probability alpha value of 0.05 (0.000 < 0.05). The R2 test results in this study was obtained R2 value of 0.413. This shows that purchase interest is influenced by trust, risk perception, use perception, and price perception by 41.3%, while the remaining 58.7% is influenced by other factors not observed by the researcher or considered fixed.
PENGARUH BAURAN PROMOSI TERHADAP VOLUME PENJUALAN PADA PT. VIVA VICTORY ABADI
Authors: Komarudin Komarudin , Setyono Hendro 
Published: April 2021

The purpose of this study was to determine the effect on promotion mix on volume sales PT Viva Victory Abadi. Results are expected to be a consideration for managers PT Viva Victory Abadi in determining the promotional mix effect on sales of property, as well as using some other variables of the promotion mix. The study was based on data usage all promotional costs incurred as well as the sale of the property from PT Viva Victory Abadi in the last two years. The data is then processed using multiple linear regression method in SPSS. The results obtained prove not the absence of significant promotional mix on volume sales of PT Viva Victory Abadi.
High visibility of outdoor tobacco advertisements around health facilities in East Java, Indonesia: a geospatial analysis
Authors: Megatsari Hario , Akhsanu Ridlo Ilham , Kusuma Dian 
Published: April 2021

BACKGROUND Indonesian tobacco control initiatives are minimal despite having the second-highest adult male smoking prevalence in the world, with less than 10% of districts/cities banning outdoor tobacco advertisements. This research aimed to provide evidence on the presence of outdoor tobacco advertisements near health facilities in Surabaya where there is no outdoor advertising ban.
METHODS Data collection was carried out in Surabaya from October to November 2018. Data of government (public) and private health facilities were obtained from the city health office. Two spatial data analyses were carried out: a buffer analysis near the healthcare facilities and an advertisement hotspot analysis using ArcMap 10.6.
RESULTS From 308 tobacco advertisements that were identified, there were billboards (63%), banners (31%), and videoboards (7%). Of 142 public and 1,242 private health facilities in Surabaya, 26% and 31% had advertisements within 300 m and 63% and 70% were within advertisement hotspots, respectively. Furthermore, 5% of advertisements were within 300 m from public health facilities and 21% of them were within 300 m from private health facilities.
CONCLUSIONS Outdoor tobacco advertisements were widespread throughout the city, prominently around public and private health facilities.