bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated Optical Tweezers Manipulation to Transfer Mitochondria from Fetal to Adult MSCs to Improve Antiaging Gene Expressions
Authors: Shakoor Adnan , Wang Bin , Fan Lei , Kong Lingchi , Gao Wendi , Sun Jiayu , Man Kwan , Li Gang , Sun Dong 
Published: August 2021

AbstractMitochondrial dysfunction is considered to be an important factor that leads to aging and premature aging diseases. Transferring mitochondria to cells is an emerging and promising technique for the therapy of mitochondrial deoxyribonucleic acid (mtDNA)‐related diseases. This paper presents a unique method of controlling the quality and quantity of mitochondria transferred to single cells using an automated optical tweezer‐based micromanipulation system. The proposed method can automatically, accurately, and efficiently collect and transport healthy mitochondria to cells, and the recipient cells then take up the mitochondria through endocytosis. The results of the study reveal the possibility of using mitochondria from fetal mesenchymal stem cells (fMSCs) as a potential source to reverse the aging‐related phenotype and improve metabolic activities in adult mesenchymal stem cells (aMSCs). The results of the quantitative polymerase chain reaction analysis show that the transfer of isolated mitochondria from fMSCs to a single aMSC can significantly increase the antiaging and metabolic gene expression in the aMSC. The proposed mitochondrial transfer method can greatly promote precision medicine for cell therapy of mtDNA‐related diseases.
New and revised small shelly fossil record from the lower Cambrian of northern Iran
Authors: Devaere Léa , Korn Dieter , Ghaderi Abbas , Struck Ulrich , Bavandpur Alireza K. 
Published: August 2021

AbstractSmall shelly fossils (SSFs) are highly informative of the ‘Cambrian explosion’. Their palaeobiodiversity has been documented from lower Cambrian deposits worldwide but it remains elusive in areas such as Iran, despite this region occupying a critical position on the north‐western Gondwana margin during the early Cambrian. This new study of the SSFs of the lower Cambrian of northern Iran provides a large new dataset from this understudied area. We revise the micropalaeontological signal of the Soltanieh Formation of the Alborz Mountains and introduce novel data from the Soltanieh and overlying Barut Formations of the Soltanieh Mountains. The new, solid taxonomic and stratigraphic SSF data enable us to distinguish two successive microfaunal assemblages. The first occurs in the Soltanieh Formation of the Soltanieh and Alborz Mountains and is dominated by anabaritids (Anabarites trisulcatus,A. ex gr. trisulcatus,A. tristichus,A. dalirensesp. nov.,Cambrotubulus decurvatus) along with protoconodonts (Protohertzina anabaricaandP. unguliformis), maikhanellids (Maikhanella multa,Purella squamulosaandPurellasp.),Aetholicopalla adnata, indeterminate cones and irregular tubes. The second assemblage, from the Barut Formation, is dominated by a diverse assemblage of molluscs (Oelandiella korobkoviand cap‐shaped morphotypes). Siphogonuchitid sclerites also occur in both assemblages. The two SSF assemblages are characteristic of the Terreneuvian. Our dataset enables us to assess the sequence of faunal change of the Ediacaran–Cambrian transition; in contrast to the tube–sclerite–brachiopod succession presented in the literature, the Iranian fauna changes from one dominated by tubes and sclerites, to one dominated by molluscs and sclerites.
Early socialisation in group lactation system reduces post‐weaning aggression in piglets
Authors: Fels Michaela , Schrey Lilith , Rauterberg Sally , Kemper Nicole 
Published: August 2021

AbstractBackgroundPre‐weaning group housing for sows and their litters is expected to enhance animal welfare. However, knowledge of potential benefits of pre‐weaning socialisation for piglets after weaning is still lacking.MethodsWeaner pigs were mixed in groups of 10, using littermates (LM) from pre‐weaning group housing (Gr) and from farrowing pens with crates (Co). Groups were formed as follows: Gr/Gr (5 LM from Gr + 5 LM from Gr), Gr/Co (5 LM from Gr + 5 LM from Co), Co/Co (5 LM from Co + 5 LM from Co).ResultsDuring 24 h after mixing, piglets in Co/Co fought more than in Gr/Co and Gr/Gr. Piglets in Co/Co had more unclear fighting results than in Gr/Co and Gr/Gr. Four days after mixing, piglets in Co/Co were more injured than in Gr/Co and Gr/Gr.ConclusionEarly socialised piglets may have better social skills when meeting familiar and unfamiliar conspecifics after weaning.
Humanitarian forensic action: A new forensic discipline helping to implement international law and construct peace
Authors: Tidball‐Binz Morris V. , Cordner Stephen 
Published: August 2021

AsbtractHumanitarian forensic action, a novel field of application of forensic science, has evolved to assist the humanitarian response to armed conflicts, other situations of violence and catastrophic events. It is discipline framed by International Humanitarian and Human Rights Law and it was shaped up by the early experience of the Argentine Forensic Anthropology Team and that of the Grandmothers of Plaza de Mayo in Argentina during the 80s and 90s and later developed by international organizations, including the United Nations and the International Committee of the Red Cross. Having demonstrated its worth, including for peace‐building, and evolving rapidly, this new field of application of forensic medicine and science needs further development, integration, and research to meet growing needs at global scale.This article is categorized under:
Forensic Medicine > Mass Casualty Management
Forensic Anthropology > Anthropology in Mass Disaster & War Crime Contexts
Forensic Biology > Ethical and Social Implications
Einleitung: Video-on-Demand – Quell der Innovation?
Authors: Kelsch Jakob 
Published: August 2021

ZusammenfassungIn der Einleitung der Untersuchung werden Forschungsfrage und Methodik dargelegt. Zudem werden grundlegende Charakteristika des audiovisuellen Erzählens skizziert und das Analysekorpus vorgestellt. In Zeiten ubiquitärer Digitalisierung verdrängen Streaming-Dienste den traditionellen Film- und Fernsehkonsum. Video-on-Demand-Serien weichen auf Produktions-, Distributions- und Rezeptionsebene von konventionellen TV-Serien ab. Dementsprechend liegt es nahe, ein allgemeinen Wandel des Formats „Serie“ anzunehmen, auch da der Innovationscharakter der Video-on-Demand-Serien von journalistischer Seite häufig betont wurde. Anhand eines prominent medial verhandelten Aspekts des gesellschaftlichen Lebens, nähere ich mich diesem potenziellen Wandel auf inhaltlicher Ebene an: Familie als Keimzelle des Privaten. Die Forschungsfrage lautet: Welche Modelle und Ideale von Familie dominieren in der Video-on-Demand-Serie und welche gesellschaftlichen und kulturellen Paradigmen werden als zentral gesetzt?
Resümee und Ausblick: Serien der Zukunft – Familien der Zukunft
Authors: Kelsch Jakob 
Published: August 2021

ZusammenfassungIm abschließenden fünften Kapitel wird einen Ausblick auf die mögliche Anschlussfähigkeit der Studie gegeben. Zudem wird die Frage gestellt, inwieweit die Ergebnisse auf gesellschaftlicher Ebene aussagekräftig sind. In Zeiten einer zunehmenden Globalisierung und Digitalisierung erscheint der geschlossene Raum der Kernfamilie als überschaubarer und begreifbarer Ausgleich zu einer zunehmend als unübersichtlich und chaotisch wahrgenommenen Welt. Trotz Konflikten mir der Realität wird sich dieses tief im populärkulturellen Bewusstsein verankerte Idealbild nicht ohne weiteres auflösen. Wenn also eine Entwicklung stattfindet, so geschieht dies langsam und sukzessive. Kann die Video-on-Demand Serie auch als impulsgebend in der aktuellen Serienlandschaft gelten, so wäre es doch vorschnell und naiv hinter jedem neuen Medium zugleich auch eine inhaltliche Revolution zu erwarten. Was die Zukunft der Video-on-Demand-Serie bringt und welchen Einfluss Streaming Dienste auf die Medienproduktion haben ist zum aktuellen Zeitpunkt nur vage zu erahnen. Hier bestehen zahlreiche Anknüpfungspunkte für weitere Forschung.
Capital Share Risk in International Asset Pricing
Authors: Müller Birgit Charlotte 
Published: August 2021

ZusammenfassungIn a seminal study, Lettau et al. (2019) demonstrate that a single macroeconomic factor can explain a wide range of equity and nonequity portfolio returns within the U.S. market. This factor, which is based on the growth in the capital share of aggregate income, is able to outperform, yet even subsume information in well-established factor models as for instance the Fama-French three factor model. The aim of this paper is to study whether the explanatory power of this factor maintains across international equity markets.
The Pricing of European Non-Performing Real Estate Loan Portfolios
Authors: Müller Birgit Charlotte 
Published: August 2021

ZusammenfassungNon-performing loans (NPL), commonly referred to as loans in arrears for at least 90 days, have continuously been characterized as the top priority of the European Central Bank (ECB) and continue to attract central attention (ECB, 2018a,b). With the outbreak of the European debt crisis, the quality of banks’ assets had deteriorated in a manner that, despite robust economic recovery and a variety of regulatory efforts, NPL still today pose a threat to bank and thrift institutions. Against this backdrop, the European regulator requires banks to develop effective strategies for reducing NPL, to set up clear governance and to operate powerful work-out structures (ECB, 2017).
Actions for self-dual Higher Spin Gravities
Authors: Krasnov Kirill , Skvortsov Evgeny , Tran Tung 
Published: August 2021

Abstract
Higher Spin Gravities are scarce, but covariant actions for them are even scarcer. We construct covariant actions for contractions of Chiral Higher Spin Gravity that represent higher spin extensions of self-dual Yang-Mills and self-dual Gravity theories. The actions give examples of complete higher spin theories both in flat and (anti)-de Sitter spaces that feature gauge and gravitational interactions. The actions are based on a new description of higher spin fields, whose origin can be traced to early works on twistor theory. The new description simplifies the structure of interactions. In particular, we find a covariant form of the minimal gravitational interaction for higher spin fields both in flat and anti-de Sitter space, which resolves some of the puzzles in the literature.
Variation of the modulus of elasticity of aligner foil sheet materials due to thermoforming
Authors: Golkhani Bijan , Weber Anna , Keilig Ludger , Reimann Susanne , Bourauel Christoph 
Published: August 2021

Abstract
Objective
Investigate and compare the mechanical properties of different aligner materials before and after deep drawing and determine differences in the mechanical properties after thermoforming.

Materials and methods
Four aligner film sheets from three manufacturers (Duran Plus® [Scheu Dental, Iserlohn, Germany]; Zendura® [ClearCorrect, Bay Materials LLC, Fremont, CA, USA]; Essix ACE® and Essix® PLUS™ [Dentsply Sirona Deutschland, Bensheim, Germany]) were tested in 3‑point bending with support distances of 8, 16, and 24 mm. Dimension of the specimens was 10 × 50 mm2. Two groups each were tested: (1) 10 specimens were investigated in the as-received state (before thermoforming), (2) 10 specimens were deep drawn on a master plate with cuboids of the dimension 10 × 10 × 50 mm3. Then, specimens were cut out of the upper side and lateral walls and were measured in 3‑point bending. Forces and reduction in thickness were measured and corrected theoretical forces of drawn sheets after thickness reduction as well as Young’s modulus were calculated.

Results
At a support distance of 8 mm and a displacement of 0.25 mm Essix® PLUS™, having the highest thickness in untreated state, showed highest forces of 28.2 N, followed by Duran Plus® (27.3 N), Essix ACE® (21.0 N) and Zendura® (19.7 N). Similar results were registered for the other distances (16, 24 mm). Thermoforming drastically reduced thickness and forces in the bending tests. Forces decreased to around 10% or less for specimens cut from the lateral walls. Young’s modulus decreased significantly for deep drawn foil sheets, especially for Essix® PLUS™.

Conclusions
Three-point bending is an appropriate method to compare different foil sheet materials. Young’s modulus is significantly affected by thermoforming.
Vinorelbine in bladder-preserving multimodality treatment for muscle-invasive bladder cancer—a valid option for cisplatin-unfit patients?
Authors: Arnold C. R. , Lindner A. K. , Schachtner G. , Tulchiner G. , Tulchiner N. , Mangesius J. , Maffei M. , Horninger W. , Kouvaiou O. , Lukas P. , Ganswindt U. , Pichler R. , Skvortsov S. 
Published: August 2021

Abstract
Purpose
Treatment of muscle-invasive bladder cancer (MIBC) remains challenging, especially for elderly and/or comorbid patients. Patients who are unfit for or refuse surgery should receive bladder-preserving multimodality treatment (BPMT), consisting of transurethral resection of the bladder tumor (TURB) followed by combined chemoradiotherapy (CRT). We aimed to investigate the effectiveness of vinorelbine, a chemotherapeutic agent not routinely used for MIBC, in patients referred to CRT who are unfit for standard chemotherapy and would thus rely solely on radiotherapy (RT).

Methods
We retrospectively analyzed 52 consecutive patients with MIBC who received standard CRT with cisplatin (n = 14), CRT with vinorelbine (n = 26), or RT alone (n = 12). Primary endpoints were median overall survival (OS) and median cancer-specific survival (CSS). Secondary endpoints were median local control (LC), median distant control (DC), and OS, CSS, LC, and DC after 1, 2, and 3 years, respectively.

Results
Median OS and CSS were significantly higher for patients who received vinorelbine as compared to RT alone (OS 8 vs. 22 months, p = 0.003; CSS 11 months vs. not reached, p = 0.001). Median LC and DC did not differ significantly between groups. Vinorelbine was well tolerated with no reported side effects >grade II.

Conclusion
Our results suggest that CRT with vinorelbine is well tolerated and superior to RT alone in terms of OS and CSS. Therefore, this treatment regime might constitute a new treatment option for patients with MIBC who are unfit for or refuse surgery or standard chemotherapy. This study encourages a randomized controlled trial to compare this new regime to current standard therapies.
The local-to-global property for Morse quasi-geodesics
Authors: Russell Jacob , Spriano Davide , Tran Hung Cong 
Published: August 2021

AbstractWe show the mapping class group,$${{\,\mathrm{CAT}\,}}(0)$$CAT(0)groups, the fundamental groups of closed 3-manifolds, and certain relatively hyperbolic groups have a local-to-global property for Morse quasi-geodesics. This allows us to generalize combination theorems of Gitik for quasiconvex subgroups of hyperbolic groups to the stable subgroups of these groups. In the case of the mapping class group, this gives combination theorems for convex cocompact subgroups. We show a number of additional consequences of this local-to-global property, including a Cartan–Hadamard type theorem for detecting hyperbolicity locally and discreteness of translation length of conjugacy classes of Morse elements with a fixed gauge. To prove the relatively hyperbolic case, we develop a theory of deep points for local quasi-geodesics in relatively hyperbolic spaces, extending work of Hruska.
Systemic mesalazine treatment prevents spontaneous skin fibrosis in PLK2-deficient mice
Authors: Newe Manja , Kant Theresa A. , Hoffmann Maximilian , Rausch Johanna S. E. , Winter Luise , Künzel Karolina , Klapproth Erik , Günther Claudia , Künzel Stephan R. 
Published: August 2021

Abstract
Skin fibrosis is a complex biological remodeling process occurring in disease like systemic sclerosis, morphea, or eosinophilic fasciitis. Since the knowledge about the underlying pathomechanisms is still incomplete, there is currently no therapy, which prevents or reverses skin fibrosis sufficiently. The present study investigates the role of polo-like kinase 2 (PLK2) and the pro-fibrotic cytokine osteopontin (OPN) in the pathogenesis of cutaneous fibrosis and demonstrates the antifibrotic effects of systemic mesalazine treatment in vivo. Isolated primary dermal fibroblasts of PLK2 wild-type (WT) and knockout (KO) mice were characterized invitro. Skin thickness and histoarchitecture were studied in paraffin-embedded skin sections. The effects of mesalazine treatment were examined in isolated fibroblasts and PLK2 KO mice, which were fed 100 µg/g mesalazine for 6 months via the drinking water. Compared to WT, PLK2 KO fibroblasts displayed higher spontaneous myofibroblast differentiation, reduced proliferation rates, and overexpression of the fibrotic cytokine OPN. Invitro, 72 h of treatment with 10 mmol/L mesalazine induced phenotype conversion in PLK2 KO fibroblasts and attenuated OPN expression by inhibiting ERK1/2. In vivo, dermal myofibroblast differentiation, collagen accumulation, and skin thickening were prevented by mesalazine in PLK2 KO. Plasma creatinine levels indicated good tolerability of systemic long-term mesalazine treatment. The current study reveals a spontaneous fibrotic skin phenotype and ERK1/2-dependent OPN overexpression in PLK2 KO mice. We provide experimental evidence for the antifibrotic effectiveness of systemic mesalazine treatment to prevent fibrosis of the skin, suggesting further investigation in experimental and clinical settings.
Worst-case Recovery Guarantees for Least Squares Approximation Using Random Samples
Authors: Kämmerer Lutz , Ullrich Tino , Volkmer Toni 
Published: August 2021

AbstractWe construct a least squares approximation method for the recovery of complex-valued functions from a reproducing kernel Hilbert space on $$D \subset \mathbb {R}^d$$

D
⊂

R

d

. The nodes are drawn at random for the whole class of functions, and the error is measured in $$L_2(D,\varrho _{D})$$

L
2

(
D
,

ϱ
D

)

. We prove worst-case recovery guarantees by explicitly controlling all the involved constants. This leads to new preasymptotic recovery bounds with high probability for the error of hyperbolic Fourier regression on multivariate data. In addition, we further investigate its counterpart hyperbolic wavelet regression also based on least squares to recover non-periodic functions from random samples. Finally, we reconsider the analysis of a cubature method based on plain random points with optimal weights and reveal near-optimal worst-case error bounds with high probability. It turns out that this simple method can compete with the quasi-Monte Carlo methods in the literature which are based on lattices and digital nets.
Modularisierung von Steuerungssoftware
Authors: Melik Merkumians Martin , Gsellmann Peter , Schitter Georg 
Published: August 2021

ZusammenfassungModularisierung und Verteilung der Aufgaben einer Automationsanlage sind die Kernelemente zur Steigerung der Wiederverwendbarkeit von Automationshard- und software. Hierfür werden ein neuer Hierarchisierungsansatz für Automationssysteme, der die Ablaufsteuerung weitestgehend von der Hardwaresteuerung entkoppelt, und eine nahtlose Integration von zyklusbasierten IEC-61131-Systemen in die Entwicklungsmodelle der eventgesteuerten IEC 61499 präsentiert. Beide Ansätze legen hierbei besonderes Augenmerk auf die Wiederverwendbarkeit von Software.
„Die Puppe hat Luftnot“ – Simulation zum interprofessionellen Lernen im Team: aber sinnvoll!
Authors: Grande B. , Breckwoldt J. , Kolbe M. 
Published: August 2021

ZusammenfassungAusbildungskonzepte, die eine Simulation von Fällen und Szenarien aller Art nutzen, haben breiten Eingang in Curricula und Praxis gefunden. Ein Vertrauen in technische Simulationsmethoden ohne qualifizierte Ausbildung in der Methode kann schaden. Deswegen sollte nach der Auswahl der korrekten Simulationsmethode großer Wert auf die Durchführung der Simulation gelegt werden. Neben einem strukturierten Design der simulierten Szenarien und der korrekten technischen Durchführung ist für den Lernerfolg vor allem das Debriefing, die Nachbesprechung, entscheidend. Prüfungen mit Simulation als Methode sind nur zu empfehlen, wenn sie von Trainings getrennt durchgeführt werden und die Bewertung nach transparenten, validierten Kriterien erfolgt.
Long-term effectiveness and drug survival of golimumab in patients affected by psoriatic arthritis with cutaneous involvement
Authors: Chimenti Maria Sole , Conigliaro Paola , Caso Francesco , Costa Luisa , Ortolan Augusta , Triggianese Paola , Tasso Marco , Fonti Giulia Lavinia , Lorenzin Maria Grazia , Perricone Roberto , Ramonda Roberta 
Published: August 2021

Abstract
Objectives
To determine the effectiveness of golimumab (GLM) in improving joint, periarticular structures and cutaneous manifestations in patients with moderate to severe psoriatic arthritis (PsA) with cutaneous psoriasis in different real-life clinical settings and 48-month drug survival.

Methods
Clinical and laboratory records were collected from PsA patients treated with GLM at baseline (T0) and after 6, 12, 24, 36, and 48 months of treatment. Comparisons were performed using a paired t-test or Wilcoxon test. Drug survival rates were analyzed using Kaplan–Meier estimates. p value < 0.05 was considered statistically significant.

Results
Data from 105 patients were collected. PsO occurred in 80% of patients and enthesitis in 78%, peripheral and axial arthritis in 63.8% and 35.3%, respectively, while erosions in 36.2%. The main comorbidities were cardiovascular diseases (31.4%) and metabolic syndrome (MetS) (19%). A statistically significant improvement in articular and cutaneous psoriasis was registered at T48 of GLM-therapy in clinical (DAPSA p < 0.0001; PASI p < 0.01; BASDAI p < 0.0001) and laboratory (CRP < 0.05) indexes. Gender (p = 0.652), BMI (p = 0.655), smoking habit (p = 0.466), and line of treatment (p = 0.208) did not affect treatment efficacy nor persistence. At T48, 42% of patients discontinued GLM: the most frequent reason was an insufficient response or loss of efficacy (28.6%).

Conclusion
A 48-month GLM high drug persistence of PsA patients was observed in real-life, in patients presenting high disease activity, elevated prevalence of comorbidities, and more than one line of treatment at baseline. Patients’ characteristics as gender, smoke, BMI, different lines of treatment, and concomitant methotrexate treatment affected treatment persistence, making GLM effective and safe in moderate-severe PsA in a long-term real-life setting.

Key Points• Golimumab was effective in psoriatic arthritis, including both musculoskeletal and cutaneous manifestations. • Golimumab effectiveness and drug survival were not affected by comorbidities and patient-related characteristics. • The 4-year drug survival curves confirm the efficacy and safety of golimumab in psoriatic arthritis patients in a real-life setting.