bluuebunny/crossref_metadata_2025_split huggingface dataset:
p-Nilpotent Maximal Subgroups in Finite Groups
Authors: Beltrán Antonio , Shao Changguo 
Published: December 2024

AbstractLet p be a prime number and suppose that every maximal subgroup of a finite group is either p-nilpotent or has prime index. Such a group need not be p-solvable, and we study its structure by proving that only one nonabelian simple group of order divisible by p, which belongs to the family $$\textrm{PSL}_n(q)$$

PSL
n

(
q
)

, can be involved in it. For $$p=2$$

p
=
2

, we specify more, and in fact, such a simple group must be isomorphic to $$\textrm{PSL}_2({r^a})$$

PSL
2

(

r
a

)

for certain values of the prime r and the parameter a.
Genetic modeling of degenerative diseases and mechanisms of neuronal regeneration in the zebrafish cerebellum
Authors: Namikawa Kazuhiko , Pose-Méndez Sol , Köster Reinhard W. 
Published: December 2024

AbstractThe cerebellum is a highly conserved brain compartment of vertebrates. Genetic diseases of the human cerebellum often lead to degeneration of the principal neuron, the Purkinje cell, resulting in locomotive deficits and socio-emotional impairments. Due to its relatively simple but highly conserved neuroanatomy and circuitry, these human diseases can be modeled well in vertebrates amenable for genetic manipulation. In the recent years, cerebellar research in zebrafish has contributed to understanding cerebellum development and function, since zebrafish larvae are not only molecularly tractable, but also accessible for high resolution in vivo imaging due to the transparency of the larvae and the ease of access to the zebrafish cerebellar cortex for microscopy approaches. Therefore, zebrafish is increasingly used for genetic modeling of human cerebellar neurodegenerative diseases and in particular of different types of Spinocerebellar Ataxias (SCAs). These models are well suited to address the underlying pathogenic mechanisms by means of in vivo cell biological studies. Furthermore, accompanying circuitry characterizations, physiological studies and behavioral analysis allow for unraveling molecular, structural and functional relationships. Moreover, unlike in mammals, zebrafish possess an astonishing ability to regenerate neuronal populations and their functional circuitry in the central nervous system including the cerebellum. Understanding the cellular and molecular processes of these regenerative processes could well serve to counteract acute and chronic loss of neurons in humans. Based on the high evolutionary conservation of the cerebellum these regeneration studies in zebrafish promise to open therapeutic avenues for counteracting cerebellar neuronal degeneration. The current review aims to provide an overview over currently existing genetic models of human cerebellar neurodegenerative diseases in zebrafish as well as neuroregeneration studies using the zebrafish cerebellum. Due to this solid foundation in cerebellar disease modeling and neuronal regeneration analysis, the zebrafish promises to become a popular model organism for both unraveling pathogenic mechanisms of human cerebellar diseases and providing entry points for therapeutic neuronal regeneration approaches.
Unified Framework for Continuity of Sandwiched Rényi Divergences
Authors: Bluhm Andreas , Capel Ángela , Gondolf Paul , Möbus Tim 
Published: December 2024

AbstractIn this work, we prove uniform continuity bounds for entropic quantities related to the sandwiched Rényi divergences such as the sandwiched Rényi conditional entropy. We follow three different approaches: The first one is the “almost additive approach”, which exploits the sub-/superadditivity and joint concavity/convexity of the exponential of the divergence. In our second approach, termed the “operator space approach”, we express the entropic measures as norms and utilize their properties for establishing the bounds. These norms draw inspiration from interpolation space norms. We not only demonstrate the norm properties solely relying on matrix analysis tools but also extend their applicability to a context that holds relevance in resource theories. By this, we extend the strategies of Marwah and Dupuis as well as Beigi and Goodarzi employed in the sandwiched Rényi conditional entropy context. Finally, we merge the approaches into a mixed approach that has some advantageous properties and then discuss in which regimes each bound performs best. Our results improve over the previous best continuity bounds or sometimes even give the first continuity bounds available. In a separate contribution, we use the ALAFF method, developed in a previous article by some of the authors, to study the stability of approximate quantum Markov chains.
The impact of primers for wood bonding on beech wood’s Young’s modulus
Authors: Böger Thomas , Engelhardt Max , Richter Klaus , Sanchez-Ferrer Antoni 
Published: December 2024

Abstract
When producing load-bearing timber products with one-component polyurethane adhesives and certain wood species, e.g., beech or larch, primers can be used to obtain stronger and more durable bonds. The active chemicals of three existing primer systems, hydroxymethylated resorcinol formaldehyde (HMR), polysorbate 20 (PS20), and poly(ethylene glycol) (PEG), were used to impregnate beech wood. Young’s modulus (E) in the radial direction was determined in tensile mode. A modified E can influence the deformation and stress distribution at the wood-glue interface. Compared to the untreated wood, the average E was reduced by 7% for the water-treated reference and the HMR treatment. With the PS20 treatment, the average E was reduced by 16%, compared to the untreated wood, and by 45% with the PEG treatment.
Aiding narrative generation in collaborative data utilization by humans and AI agents
Authors: Sekiguchi Kaira , Ohsawa Yukio 
Published: December 2024

AbstractNarrative generation is growing in importance for data utilization, particularly in the context of co-creation with artificial intelligence (AI) agents. Narratives can, for example, bridge theoretical objects with social understanding and promote human actions. Furthermore, clarifying the narrative generation mechanism is essential for constructing effective relationships between humans and AI agents. However, the narrative generation mechanism in data utilization processes has not been fully elucidated. In this study, we developed a framework called the hierarchical narrative representation (HieNaR) to systematize the structure of narrative generation in data utilization processes. HieNaR comprises twelve levels, ranging from the set of texts down to the particle level (e.g., text, sentence, word, character, and stroke), allowing for a comprehensive analysis of narrative structures. We evaluated the usefulness of HieNaR through case studies, examining both individual user experiences and collaborative work between humans and an AI agent. The results demonstrated that the data utilization process interprets data by inquiring whether it satisfies higher-level expectations. In collaboration, AI agents can be understood as co-creative partners in data utilization, possessing their own worldviews. Through these findings, this study not only elucidates the mechanism of narrative generation in data utilization processes but also provides a foundation for improving human–AI collaboration.
Accelerating antiviral drug discovery: early hazard detection with a dual zebrafish and cell culture screen of a 403 compound library
Authors: Truong Lisa , Bieberich Andrew A. , Fatig Raymond O. , Rajwa Bartek , Simonich Michael T. , Tanguay Robyn L. 
Published: December 2024

Abstract
The constant emergence of new viral pathogens underscores the need for continually evolving, effective antiviral drugs. A key challenge is identifying compounds that are both efficacious and safe, as many candidates fail during development due to unforeseen toxicity. To address this, the embryonic zebrafish morphology, mortality, and behavior (ZBE) screen and the SYSTEMETRIC® Cell Health Screen (CHS) were employed to evaluate the safety of 403 compounds from the Cayman Antiviral Screening Library. Of these compounds, 114 were FDA-approved, 17 were discontinued, and 97 remained on the market. CHS identified 25% (104 compounds) as toxic, with a Cell Health Index™ (CHI) > 0.5. The embryonic zebrafish model identified an additional 20% as toxic (79), bringing the total to 183. ZBEscreen flagged 19 toxic hits among compounds still on the market, seven of which were also identified by CHS. The combined use of CHS and zebrafish models enhanced hazard detection. Together, CHS and ZBEscreen identified 45.5% of the library as potentially hazardous. Notably, the zebrafish non-hazardous compounds correlated strongly with over-the-counter or prescribed antiviral drugs, confirming their known safety profile. Over 130 hazard-associated compounds warranted further investigation. Using self-organizing maps, six distinct neighborhoods of compound similarity were identified. This dual approach streamlined the early detection of hazards associated with promising leads and is expected to facilitate faster, safer antiviral discovery.
Convergence speed for Fekete points on uniformly polynomially cuspidal sets
Authors: Ahn Hyunsoo , Nguyen Ngoc Cuong 
Published: December 2024

Abstract
We obtain the convergence speed for Fekete points on uniformly polynomially cuspidal compact sets introduced by Pawłucki and Pleśniak. This is done by showing that these sets are

$$(\mathscr {C}^{\alpha }, \mathscr {C}^{\alpha '})$$

(

C
α

,

C

α
′

)

-regular in the sense of Dinh, Ma and Nguyen.
Substrate expansion of Geotrichum candidum alcohol dehydrogenase towards diaryl ketones by mutation
Authors: Tang Zhongyao , Takagi Yuuki , Koesoema Afifa Ayu , Matsuda Tomoko 
Published: December 2024

Abstract
Chiral diaryl alcohols, such as (4-chlorophenyl)(pyridin-2-yl)methanol, are important intermediates for pharmaceutical synthesis. However, using alcohol dehydrogenases (ADHs) in the asymmetric reduction of diaryl ketones to produce the corresponding alcohols is challenging due to steric hindrance in the substrate binding pockets of the enzymes. In this study, the steric hindrance of the ADH from Geotrichum candidum NBRC 4597 (G. candidum acetophenone reductase, GcAPRD) was eliminated by simultaneous site-directed mutagenesis of Phe56 (in the large pocket) and Trp288 (in the small pocket). As a result, two double mutants, Phe56Ile/Trp288Ala, and Phe56Ala/Trp288Ala, exhibited much higher specific activities towards 2-(4′-chlorobenzoyl)pyridine (4.5 μmol/min/mg and 3.4 μmol/min/mg, respectively) than the wild type (< 0.2 μmol/min/mg). In whole-cell-catalyzed asymmetric reductions of diaryl ketones, Phe56Ile/Trp288Ala significantly increased the isolated yields, which were over 90% for the reactions of most of the tested substrates. Regarding enantioselectivity, Phe56Ile/Trp288Ala and Phe56Ala/Trp288Ala, and Trp288Ala generally exhibited similar selectivity to produce (R)-alcohols with up to 97% ee.

Key points
• Phe56 in Geotrichum reductase (GcAPRD) was mutated to eliminate steric hindrance.
• Mutation at Phe56 increased enzymatic activity and expanded substrate specificity.
• Phe56Ile/Trp288Ala showed high activity and (R)-selectivity towards diaryl ketones.

Graphical Abstract
Cystic lesions and their mimics involving the intrahepatic bile ducts and peribiliary space: diagnosis, complications, and management
Authors: Khot Rachita , Ganeshan Dhakshinamoorthy , Sundaram Karthik M. , Depetris Jena N. , Ludwig Daniel R. 
Published: December 2024

AbstractBiliary and peribiliary cystic lesions represent a diverse group of abnormalities, often discovered incidentally during imaging for unrelated conditions. These lesions, typically asymptomatic, necessitate precise imaging modalities to characterize their nature and determine subsequent clinical actions, such as follow-up imaging, biopsy, or surgical referral. The anatomic location of these cystic lesions, whether biliary or peribiliary, influences both diagnostic and prognostic outcomes. Biliary cystic lesions, such as mucinous cystic neoplasms, intraductal papillary neoplasms of the bile duct, and Caroli disease, require careful monitoring due to their propensity to develop malignancy. In contrast, peribiliary cysts are often associated with chronic liver disease and may indicate disease progression through a gradual increase in cyst size. Accurate differentiation of these lesions from other clinical entities that have overlapping features on imaging, such as microabscesses, bilomas, Langerhans cell histiocytosis, neurofibromatosis, and vascular anomalies such as cavernous transformation of the portal vein, is essential given the divergent management for each. This article focuses on intrahepatic biliary and peribiliary cystic lesions and their mimics, highlighting their imaging characteristics with an emphasis on magnetic resonance imaging and magnetic resonance cholangiopancreatography, differential diagnosis, potential associated complications, and clinical management.
Discrepancy between radiography and magnetic resonance imaging in Japanese Investigation Committee classification type C osteonecrosis of the femoral head
Authors: Otaka Keiji , Osawa Yusuke , Takegami Yasuhiko , Funahashi Hiroto , Imagama Shiro 
Published: December 2024

Abstract

Purpose
The Japanese Investigation Committee (JIC) classification for osteonecrosis of the femoral head (ONFH) is based on the necrotic area relative to the weight-bearing surface on anteroposterior (AP) radiographs or central coronal MRI. Discrepancies exist between these methods, potentially related to the AP necrosis area. This study evaluated these discrepancies and the extent of AP necrotic lesions.

Methods
We retrospectively reviewed 139 patients (188 hips) with nontraumatic ONFH, JIC type C1 or C2 on radiography, and collapse < 3 mm. Cases with and without discrepancies between radiography and MRI were designated as discrepancy and consistent groups, respectively. We assessed the proportion of patients in the discrepancy group and survival rates in both groups, with femoral head collapse > 3 mm as the endpoint. The cutoff value for AP necrotic regions on lateral radiographs identifying discrepancies was calculated using ROC curve analysis.

Results
The discrepancy group comprised 28 hips (14.9%) vs. 160 hips in the consistent group. Five-year survival rates were 73.3% vs. 31.9% (P < 0.01), and AP necrotic region extent was 61.2 vs. 73.8 mm (P < 0.001) in discrepancy vs. consistent groups. The cutoff value for necrotic region extent revealing discrepancies was 66.9% (AUC 0.833, sensitivity 83.8%, specificity 82.4%).

Conclusion
Patients with AP necrotic regions < 66.9% were more likely to show discrepancies between radiography and MRI in type classification. This study can help improve accuracy in assessing ONFH severity and prognosis.
Regression of bilateral persistent primitive ophthalmic artery: a case report
Authors: Takeuchi Issei , Izumi Takashi , Nishihori Masahiro , Goto Shunsaku , Hanyu Taketo , Suzuki Keita , Takayanagi Kai , Kawasaki Yuichi , Saito Ryuta 
Published: December 2024

Abstract
Purpose
We report a case of regression of a 2-year-old girl with bilateral primitive ophthalmic arteries (POAs).

Case report
The patient presented with a headache and had no visual impairment or visual field abnormalities. Magnetic resonance angiography (MRA) revealed arteries originating bilaterally from the cavernous internal carotid artery segments, diagnosed as persistent POAs.

Conclusion
Six months later, MRA revealed decreased origin delineation and five years later, MRA revealed bilateral origin disappearance from the orbit to the periphery.
Predictors of treatment duration in conservative management of developmental dysplasia of hip -a retrospective cohort study
Authors: Kraus Tanja , Hammerschmid Anita , Guggenberger Bernhard , Novak Michael , Schappacher-Tilp Gudrun , Svehlik Martin 
Published: December 2024

AbstractDevelopmental dysplasia of the hip is a prevalent condition in newborns. However, predicting the duration of conservative treatment remains challenging. This study aimed to determine the duration of treatment more precisely by analyzing associated factors. We conducted a retrospective analysis and developed a linear regression model based on 503 patients treated at our institution over the last 10 years. A linear regression model (GLM) was used for predicting treatment duration (df residuals 371, df model 3, Pearson Chi2 78.9, Number of iterations 15). The baseline scenario thereby feature a child with an average age at the beginning of treatment (35th day of life), both sides pathologically affected, and a minimum alpha angle of 29 degrees. The GLM identified age at treatment onset, alpha angle, and bilaterality as significant predictors of treatment duration. A four-week delay in treatment initiation extended the duration by one week, while a 5-degree increase in the alpha angle reduced it by two weeks. Bilaterality added 19 days to treatment duration. However, sex and clinical hip instability did not significantly affect the treatment time. These findings enable the calculation of treatment duration based on identified factors, potentially improving the management and planning of conservative therapies for developmental dysplasia of the hip in newborns.
Celiac in the twenty-first century—the change in BMI of children at diagnosis over the last two decades
Authors: Kasem Ali Sliman Rim , Stein Nili , Elenberg Alter Yigal 
Published: December 2024

Abstract
This study examined the prevalence of different BMI categories among newly diagnosed pediatric celiac disease (CD) patients in Israel from 2002 to 2018. A retrospective cross-sectional study using the database of Clalit Health Services in Israel included 5520 newly diagnosed CD children aged 2–18 between 2002 and 2018. Data on BMI, gender, ethnicity, and socioeconomic status (SES) were collected and analyzed Of the 5520 CD patients, 57.5% were female, 39.7% had low SES, and 77.1% were Jewish. At diagnosis, 13.1% were underweight, 73% had normal BMI, 9.1% overweight, and 4.8% were obese. Underweight and obese patients tended to be older at diagnosis (9 years) compared with normal and overweight patients (8 years) (P < 0.001). A higher proportion of Arab patients were underweight, while more Jewish patients were obese. Lower SES was significantly associated with increased underweight risk (P < 0.001). Over time, diagnosed patients had improved SES and were less underweight (P < 0.001). Male gender increased obesity risk (OR 1.36 [95% CI 1.06–1.74], P = 0.017), while Arab ethnicity was protective for obesity (OR 0.67 [95% CI, (0.45–0.99)], P = 0.047)

Conclusion: Underweight prevalence significantly decreased in the second decade, but no significant change in overweight and obesity was noted. Underweight was associated with older age at diagnosis, poverty, and Arab ethnicity. Obesity was associated with older age and was more frequent in Jewish and male patients. Physicians should have a low threshold for CD screening regardless of BMI status to enable timely diagnosis and treatment to prevent long-term health consequences.

What Is Known:
• Celiac disease is traditionally associated with underweight due to malabsorption, but recent reports suggest an increasing prevalence of overweight and obesity in pediatric patients at diagnosis
What Is New:
• This study found that underweight prevalence decreased significantly over time, while overweight and obesity prevalence remained unchanged. Underweight was associated with older age, poverty, and Arab ethnicity, while obesity was more common in Jewish and male patients
Seismic velocity changes from repetitive seismicity at Mauna Loa prior to and during its 2022 eruption
Authors: Hotovec-Ellis Alicia J. 
Published: December 2024

Abstract
Mauna Loa’s short-lived eruption from late November to early December 2022 marked the culmination of nearly a decade of elevated seismic activity and geodetic inflation. The volcano has been monitored by a network of permanent, short period and broadband seismometers. I used the continuous waveform data from that network starting in 2012 to generate a catalog of seismicity that enhances the US Geological Survey Hawaiian Volcano Observatory’s public seismic catalog with four times the number of earthquakes, which were then grouped by waveform similarity. Analysis of subtle delays in the timing of arrivals of scattered waves between pairs of earthquakes in this catalog yields a history of small changes in the shallow seismic velocity structure of the volcano. Seismic velocities have been shown at other volcanoes to change during unrest and eruption. My results show a decrease in seismic velocity centered on the summit beginning in September 2022, corresponding to the onset of a vigorous precursory swarm of seismic activity and shallow inflation. During the eruption itself, I observe large changes due likely to dike opening along the northeast rift zone and deflation of the summit reservoir. However, seismic velocity changes associated with non-volcanic sources such as ground shaking from large earthquakes and meteorological influences at seasonal and diurnal time scales are also observed, and these dominate the velocity changes prior to the eruption. Proper accounting of these effects will be a requirement for use in real-time monitoring, and this work serves as a starting point in that endeavor for Mauna Loa.
Childhood idiopathic nephrotic syndrome: recent advancements shaping future guidelines
Authors: Chan Eugene Yu-hin , Boyer Olivia 
Published: December 2024

AbstractChildhood idiopathic nephrotic syndrome is an important pediatric kidney disease associated with significant morbidities and even mortality. Several guidelines have been developed to standardize the terminology and patient care among the pediatric nephrology community. Since the publication of these guidelines, there have been major breakthroughs in the disease management and the understanding of underlying pathogenesis through multi-omics investigations, including the identification of anti-nephrin autoantibodies, genetic susceptibility loci, and the pathogenic role of B cell subsets. In this educational review, we summarize the recent major advancements in idiopathic nephrotic syndrome and attempt to provide potential therapeutic approaches in both steroid-sensitive and steroid-resistant nephrotic syndrome that may shape future guideline development.
Graphical abstract
Measuring the biomechanical properties of cell-derived fibronectin fibrils
Authors: Dalton Caleb J. , Dhakal Soma , Lemmon Christopher A. 
Published: December 2024

AbstractEmbryonic development, wound healing, and organogenesis all require assembly of the extracellular matrix protein fibronectin (FN) into insoluble, viscoelastic fibrils. FN fibrils mediate cell migration, force generation, angiogenic sprouting, and collagen deposition. While the critical role of FN fibrils has long been appreciated, we still have an extremely poor understanding of their mechanical properties and how these mechanical properties facilitate cellular responses. Here, we demonstrate the development of a system to probe the mechanics of cell-derived FN fibrils and present quantified mechanical properties of these fibrils. We demonstrate that: fibril elasticity can be classified into three phenotypes: linearly elastic, strain-hardening, or nonlinear with a “toe” region; fibrils exhibit pre-conditioning, with nonlinear “toe” fibrils becoming more linear with repeated stretch and strain-hardened fibrils becoming less linear with repeated stretch; fibrils exhibit an average elastic modulus of roughly 8 MPa; and fibrils exhibit a time-dependent viscoelastic behavior, exhibiting a transition from a stress relaxation response to an inverse stress relaxation response. These findings have a potentially significant impact on our understanding of cellular mechanical responses in fibrotic diseases and embryonic development, where FN fibrils play a major role.