bluuebunny/crossref_metadata_2025_split huggingface dataset:
All shallow coastal habitats matter as nurseries for Mediterranean juvenile fish
Authors: Cheminée Adrien , Le Direach Laurence , Rouanet Elodie , Astruch Patrick , Goujard Adrien , Blanfuné Aurélie , Bonhomme Denis , Chassaing Laureline , Jouvenel Jean-Yves , Ruitton Sandrine , Thibaut Thierry , Harmelin-Vivien Mireille 
Published: July 2021

AbstractCoastal zones are ecosystems of high economic value but exposed to numerous disturbances, while they represent nurseries for many fish species, raising the issue of the preservation of their functions and services. In this context, the juvenile fish assemblages of all types of habitats present in shallow coastal zones were studied on the south-east coast of France using underwater visual censuses in warm (June–July 2014) and cold (April 2015) periods. A total of fourteen habitat types were characterized, which could be grouped into three broad categories, rocky substrates (natural and artificial), sedimentary bottoms with all levels of granulometry, and seagrass beds including Cymodocea nodosa and Posidonia oceanica meadows; the ecotones or interfaces between the three broad habitat categories were individualized as particular habitat types. The abiotic and biotic descriptors of the 14 habitat types individualized did not vary with time, except for a higher cover percentage and canopy height of macrophytes in the warm period, which increased the three-dimensional structure of some habitats. The taxonomic composition and density of juvenile fish assemblages were analyzed using both multivariate and univariate descriptors, after grouping the 57 fish species recorded into 41 well-individualized taxa. Juvenile fishes were recorded in all habitat types, with higher mean species richness and abundance during the warm than the cold period. The richest habitats in terms of both fish species richness and abundance were the natural rocky substrates and the interfaces between Posidonia beds and the other habitats. Although juvenile fish assemblage composition differed among habitat types and between periods, the most abundant fish species were Atherina sp., Sarpa salpa, Gobiidae, Symphodus spp., Pagellus spp. and several Diplodus species, which colonized 7 up to 14 different habitat types (depending on taxa) during their juvenile life. Most species settled in one or a few specific habitats but rapidly colonized adjacent habitats when growing. This study provided evidence of the role of all types of shallow coastal habitats as fish nurseries and their varying pattern of occupation in space and time by the different juvenile stages. It highlighted the importance of the mosaic of habitats and interfaces for the complete development of all juvenile life stages of fishes, and for the preservation of a high diversity of coastal fish assemblages and fisheries resources in the Mediterranean Sea.
A Mendelian randomization analysis of the relationship between cardioembolic risk factors and ischemic stroke
Authors: Tian Danyang , Zhang Linjing , Zhuang Zhenhuang , Huang Tao , Fan Dongsheng 
Published: July 2021

AbstractObservational studies have shown that several risk factors are associated with cardioembolic stroke. However, whether such associations reflect causality remains unknown. We aimed to determine whether established and provisional cardioembolic risk factors are causally associated with cardioembolic stroke. Genetic instruments for atrial fibrillation (AF), myocardial infarction (MI), electrocardiogram (ECG) indices and N-terminal pro-brain natriuretic peptide (NT-pro BNP) were obtained from large genetic consortiums. Summarized data of ischemic stroke and its subtypes were extracted from the MEGASTROKE consortium. Causal estimates were calculated by applying inverse-variance weighted analysis, weighted median analysis, simple median analysis and Mendelian randomization (MR)-Egger regression. Genetically predicted AF was significantly associated with higher odds of ischemic stroke (odds ratio (OR): 1.20, 95% confidence intervals (CI): 1.16–1.24, P = 6.53 × 10–30) and cardioembolic stroke (OR: 1.95, 95% CI: 1.85–2.06, P = 8.81 × 10–125). Suggestive associations were found between genetically determined resting heart rate and higher odds of ischemic stroke (OR: 1.01, 95% CI: 1.00–1.02, P = 0.005), large-artery atherosclerotic stroke (OR: 1.02, 95% CI: 1.00–1.04, P = 0.026) and cardioembolic stroke (OR: 1.02, 95% CI: 1.00–1.04, P = 0.028). There was no causal association of P‐wave terminal force in the precordial lead V1 (PTFVI), P-wave duration (PWD), NT-pro BNP or PR interval with ischemic stroke or any subtype.
Molecular dynamics of rolling and twisting motion of amorphous nanoparticles
Authors: Umstätter Philipp , Urbassek Herbert M. 
Published: July 2021

AbstractGranular mechanics codes use macroscopic laws to describe the damping of rolling and twisting motion in granular ensembles. We employ molecular dynamics simulation of amorphous Lennard–Jones grains to explore the applicability of these laws for nm-sized particles. We find the adhesive force to be linear in the intergrain attraction, as in the macroscopic theory. However, the damping torque of rolling motion is strongly superlinear in the intergrain attraction. This is caused by the strong increase of the ‘lever arm’ responsible for the damping torque—characterizing the asymmetry of the adhesive neck during rolling motion—with the surface energy of the grains. Also the damping torque of twisting motion follows the macroscopic theory based on sliding friction, which predicts the torque to increase whit the cube of the contact radius; here the dynamic increase of the contact radius with angular velocity is taken into account.
Prediction of hypotension after postural change in robot-assisted laparoscopic prostatectomy using esophageal Doppler monitoring: a prospective observational trial
Authors: Kim Na Young , Kim Ki Jun , Kim Tae Lim , Shin Hye Jung , Oh Chaerim , Lee Min Huiy , Min Ji Young , Kim So Yeon 
Published: July 2021

AbstractPostural change from a steep Trendelenburg position to a supine position (T-off) during robot-assisted laparoscopic prostatectomy (RALP) induces a considerable abrupt decrease in the mean arterial pressure (MAP). We investigated the variables for predicting postural hypotension induced by T-off using esophageal Doppler monitoring (EDM). One hundred and twenty-five patients undergoing RALP were enrolled. Data on the MAP, heart rate, stroke volume index (SVI), cardiac index, peak velocity, corrected flow time, stroke volume variation, pulse pressure variation, arterial elastance (Ea), and dynamic arterial elastance were collected before T-off and at 1, 3, 5, 7, and 10 min after T-off using EDM. MAP < 60 mmHg within 10 min after T-off was considered to indicate hypotension, and 25 patients developed hypotension. The areas under the curves of the MAP, SVI, and Ea were 0.734 (95% confidence interval [CI] 0.623–0.846; P < 0.001), 0.712 (95% CI 0.598–0.825; P < 0.001), and 0.760 (95% CI 0.646–0.875; P < 0.001), respectively, with threshold values of ≤ 74 mmHg, ≥ 42.5 mL/m2, and ≤ 1.08 mmHg/mL, respectively. If patients have MAP < 75 mmHg with SVI ≥ 42.5 mL/m2 or Ea ≤ 1.08 mmHg/mL before postural change from T-off during RALP, prompt management for ensuing hypotension should be considered.Trial registration: NCT03882697 (ClinicalTrial.gov, March 20, 2019).
KCNE4-dependent functional consequences of Kv1.3-related leukocyte physiology
Authors: Vallejo-Gracia Albert , Sastre Daniel , Colomer-Molera Magalí , Solé Laura , Navarro-Pérez María , Capera Jesusa , Roig Sara R. , Pedrós-Gámez Oriol , Estadella Irene , Szilágyi Orsolya , Panyi Gyorgy , Hajdú Péter , Felipe Antonio 
Published: July 2021

AbstractThe voltage-dependent potassium channel Kv1.3 plays essential roles in the immune system, participating in leukocyte activation, proliferation and apoptosis. The regulatory subunit KCNE4 acts as an ancillary peptide of Kv1.3, modulates K+currents and controls channel abundance at the cell surface. KCNE4-dependent regulation of the oligomeric complex fine-tunes the physiological role of Kv1.3. Thus, KCNE4 is crucial for Ca2+-dependent Kv1.3-related leukocyte functions. To better understand the role of KCNE4 in the regulation of the immune system, we manipulated its expression in various leukocyte cell lines. Jurkat T lymphocytes exhibit low KCNE4 levels, whereas CY15 dendritic cells, a model of professional antigen-presenting cells, robustly express KCNE4. When the cellular KCNE4 abundance was increased in T cells, the interaction between KCNE4 and Kv1.3 affected important T cell physiological features, such as channel rearrangement in the immunological synapse, cell growth, apoptosis and activation, as indicated by decreased IL-2 production. Conversely, ablation of KCNE4 in dendritic cells augmented proliferation. Furthermore, the LPS-dependent activation of CY15 cells, which induced Kv1.3 but not KCNE4, increased the Kv1.3-KCNE4 ratio and increased the expression of free Kv1.3 without KCNE4 interaction. Our results demonstrate that KCNE4 is a pivotal regulator of the Kv1.3 channelosome, which fine-tunes immune system physiology by modulating Kv1.3-associated leukocyte functions.
Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies
Authors: Ghoreishy Seyed Mojtaba , Ebrahimi Mousavi Sara , Asoudeh Farzaneh , Mohammadi Hamed 
Published: July 2021

AbstractPrevious studies regarding the zinc status in attention-deficit/hyperactivity disorder (ADHD) yielded inconsistent results. Thus, the present meta-analysis was aimed to estimate the association between hair and serum/plasma zinc levels and ADHD. Online databases of Medline, EMBASE, and Scopus were searched up to October 2020 with no limitation in time and language. Weighted mean differences (WMDs) of hair and serum/plasma zinc levels were calculated using a random-effects model. Overall, 22 articles with 1280 subjects with ADHD and 1200 controls were included. The pooled effect size indicated that serum/plasma zinc levels in subjects with ADHD were not statistically different than their controls (WMD = − 1.26 µmol/L; 95% CI − 3.72, 1.20). Interestingly, the exclusion of one study from the analysis showed that people with ADHD significantly have lower circulating levels of zinc compared to their controls (WMD: − 2.49 µmol/L; 95% CI − 4.29, − 0.69). Also, the pooled effect size indicated that hair zinc levels in cases with ADHD were not statistically different than their controls (WMD = − 24.19 μg/g; 95% CI − 61.80, 13.42). Present meta-analysis raises the possibility that subjects with ADHD are prone to have declined levels of zinc levels. Based on current findings, screening the zinc levels in subjects with ADHD could be reasonable. Further well-designed studies are needed to clarify the role of zinc in the etiology of ADHD.
Air pollution mitigation can reduce the brightness of the night sky in and near cities
Authors: Kocifaj Miroslav , Barentine John C. 
Published: July 2021

AbstractLight pollution is a novel environmental problem whose extent and severity are rapidly increasing. Among other concerns, it threatens global biodiversity, nocturnal animal migration, and the integrity of the ground-based astronomy research enterprise. The most familiar manifestation of light pollution is skyglow, the result of the interplay of outdoor artificial light at night (ALAN) and atmospheric scattering that obscures views of naturally dark night skies. Interventions to reduce night sky brightness (NSB) involving the adoption of modern lighting technologies are expected to yield the greatest positive environmental consequences, but other aspects of the problem have not been fully explored as bases for public policies aimed at reducing light pollution. Here we show that reducing air pollution, specifically aerosols, decreases NSB by tens of percent at relatively small distances from light sources. Cleaner city air lowers aerosol optical depth and darkens night skies, particularly in directions toward light sources, due to relatively short path lengths traversed by photons from source to observer. A field experiment demonstrating the expected changes when transitioning from conditions of elevated turbidity to cleaner air validated our hypothesis. Our results suggest new policy actions to augment and enhance existing light pollution reduction techniques targeting lighting technology and design.
Proteomics and metabonomics analyses of Covid-19 complications in patients with pulmonary fibrosis
Authors: Yang Jianrong , Chen Chunxia , Chen Wan , Huang Luying , Fu Zhao , Ye Kun , Lv Liwen , Nong Zhihuang , Zhou Xing , Lu Wensheng , Zhong Mei 
Published: July 2021

AbstractPulmonary fibrosis is a devastating disease, and the pathogenesis of this disease is not completely clear. Here, the medical records of 85 Covid-19 cases were collected, among which fibrosis and progression of fibrosis were analyzed in detail. Next, data independent acquisition (DIA) quantification proteomics and untargeted metabolomics were used to screen disease-related signaling pathways through clustering and enrichment analysis of the differential expression of proteins and metabolites. The main imaging features were lesions located in the bilateral lower lobes and involvement in five lobes. The closed association pathways were FcγR-mediated phagocytosis, PPAR signaling, TRP-inflammatory pathways, and the urea cycle. Our results provide evidence for the detection of serum biomarkers and targeted therapy in patients with Covid-19.
Assessment of quarter billion primary care prescriptions from a nationwide antimicrobial stewardship program
Authors: Gönen Mehmet , Aksoy Mesil , İşli Fatma , Gürpınar Umut Emre , Göbel Pınar , Gürsöz Hakkı , Ergönül Önder 
Published: July 2021

AbstractWe described the significance of systematic monitoring nationwide antimicrobial stewardship programs (ASPs) in primary care. All the prescriptions given by family physicians were recorded in Prescription Information System established by the Turkish Medicines and Medical Devices Agency of Ministry of Health. We calculated, for each prescription, “antibiotics amount” as number of boxes times number of items per box for medicines that belong to antiinfectives for systemic use (i.e., J01 block in the Anatomical Therapeutic Chemical Classification System). We compared the antibiotics amount before (2015) and after (2016) the extensive training programs for the family physicians. We included 266,389,209 prescriptions from state-operated family healthcare units (FHUs) between January 1, 2015 and December 31, 2016. These prescriptions were given by 26,313 individual family physicians in 22,518 FHUs for 50,713,181 individual patients. At least one antimicrobial was given in 37,024,232 (28.31%) prescriptions in 2015 and 36,154,684 (26.66%) prescriptions in 2016. The most common diagnosis was “acute upper respiratory infections (AURI)” (i.e., J00-J06 block in the 10th revision of the International Statistical Classification of Diseases and Related Health Problems) with 28.05%. The average antibiotics amount over prescriptions with AURI decreased in 79 out of 81 provinces, and overall rate of decrease in average antibiotics amount was 8.33%, where 28 and 53 provinces experienced decreases (range is between 28.63% and −3.05%) above and below this value, respectively. In the most successful province, the highest decrease in average amount of “other beta-lactam antibacterials” per prescription for AURI was 49.63% in January. Computational analyses on a big data set collected from a nationwide healthcare system brought a significant contribution in improving ASPs.
FOXD1 expression in head and neck squamous carcinoma: a study based on TCGA, GEO and meta-analysis
Authors: Huang Junjie , Liang Bin , Wang Tianjiao 
Published: July 2021

Abstract
Forkhead box D1 (FOXD1) is a new member of FOX transcription factor family. FOXD1 has demonstrated multilevel roles during normal development, and several diseases’ pathogenesis. However, little is known about the role of FOXD1 in the progression of head and neck squamous cancer (HNSC). In the present study, we analyzed FOXD1 expression pattern using The Cancer Genome Atlas (TCGA) dataset, Gene Expression Omnibus (GEO) datasets, HNSC cell lines, and HNSC tissues. Then, we analyzed the correlation between FOXD1 expression and clinical characteristics, and evaluated the prognostic value of FOXD1 in HNSC. Moreover, we assessed the relationship between FOXD1 expression and tumor microenvironment (TME) and immune cell infiltration using Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data (ESTIMATE) and Cell-type Identification By Estimating Relative Subsets Of known RNA Transcripts (CIBERSORT) algorithms. Finally, we predicted the FOXD1-related biological processes (BPs) and signal pathways. FOXD1 was up-regulated in HNSC tissues in TCGA datasets, validated by GEO datasets, HNSC cell lines and HNSC tissues. FOXD1 expression was significantly associated with tumor site and HPV infection. Univariate and multivariate Cox regression analyses showed that FOXD1 expression was an independent prognostic factor. Moreover, we found that the proportions of naïve B cells, plasma cells, and resting dendritic cells (DCs) were negatively correlated with FOXD1 expression, otherwise, the proportion of activated mast cells was positively correlated with FOXD1 expression using CIBERSORT algorithm. Gene Set Enrichment Analyses (GSEAs) revealed that FOXD1 was mainly involved in cancer-related signaling pathway and metabolism-related pathways. FOXD1 was a potential oncogene, and might represent an indicator for predicting overall survival (OS) of HNSC patients. Moreover, many cancer-related pathways and metabolism-related processes may be regulated by FOXD1.
Expanding the Role of Educational Audiologists After a Failed Newborn Hearing Screening: A Quality Improvement Study
Authors: Sapp Caitlin , Stirn Jonathan , O'Hollearn Tammy , Walker Elizabeth A. 
Published: July 2021

Purpose
Lack of timely and proximal access to diagnostic hearing evaluation using auditory brainstem response (ABR) testing hampers the effectiveness of Early Hearing Detection and Intervention (EHDI) programs in the United States. This study measured the impact of a state-based quality-improvement (QI) project that provided diagnostic ABR equipment and training to educational audiologists distributed throughout Iowa in regional special education centers.

Method
We used de-identified administrative data generated by the state EHDI program to analyze markers of access to early hearing health care for infants in a preproject condition (“Baseline”) compared to the implementation of diagnostic ABRs at the regional special education centers (“QI Project”).

Results
Our findings revealed that the QI Project was associated with improvements in timeliness of first hearing evaluation, distance traveled for first hearing evaluation, and likelihood of receiving on-guideline audiology care during the first hearing evaluation.

Conclusions
Following the onset of the QI Project, infants and their families had greater access to initial hearing evaluation after failed newborn hearing screening. This improvement could have cascading effects on timeliness of later intervention among those with confirmed permanent childhood hearing loss.
Design of planar waveguide directional couplers with arbitrary modal electric field
Authors: Boucouvalas Anthony , Angelis Kostas , Aidinis Konstantinos , Zhan Min , Wang Danshi 
Published: July 2021

AbstractThe purpose of this work is to present a method for designing planar waveguide couplers of arbitrary modal electric field distributions. The idea here is to create couplers with unusual electric fields, which confine in one planar waveguide. This is possible if a planar waveguide profile supporting two pre‐selected mode fields is designed. Their interference will have to transfer the optical power from one region (bottom layer) to another region (top layer) completely. The inverse transmission‐line technique and the desired electric field are applied, based on which the refractive index profile of the couplers exhibiting excellent crosstalk is reconstructed. By choosing this technique, it is feasible to design planar components in sensing applications, such as high power, temperature or pressure sensors and numerous other possibilities, using unusual electric field distributions.
The unusual widespread solar energetic particle event on 2013 August 19
Authors: Rodríguez-García L. , Gómez-Herrero R. , Zouganelis I. , Balmaceda L. , Nieves-Chinchilla T. , Dresing N. , Dumbović M. , Nitta N. V. , Carcaboso F. , dos Santos L. F. G. , Jian L. K. , Mays L. , Williams D. , Rodríguez-Pacheco J. 
Published: July 2021

Context. Late on 2013 August 19, STEREO-A, STEREO-B, MESSENGER, Mars Odyssey, and the L1 spacecraft, spanning a longitudinal range of 222° in the ecliptic plane, observed an energetic particle flux increase. The widespread solar energetic particle (SEP) event was associated with a coronal mass ejection (CME) that came from a region located near the far-side central meridian from Earth’s perspective. The CME erupted in two stages, and was accompanied by a late M-class flare observed as a post-eruptive arcade, persisting low-frequency (interplanetary) type II and groups of shock-accelerated type III radio bursts, all of them making this SEP event unusual.
Aims. There are two main objectives of this study, disentangling the reasons for the different intensity-time profiles observed by the spacecraft, especially at MESSENGER and STEREO-A locations, longitudinally separated by only 15°, and unravelling the single solar source related with the widespread SEP event.
Methods. The analysis of in situ data, such as particle fluxes, anisotropies and timing, and plasma and magnetic field data, is compared with the remote-sensing observations. A spheroid model is applied for the CME-driven shock reconstruction and the ENLIL model is used to characterize the heliospheric conditions, including the evolution of the magnetic connectivity to the shock.
Results. The solar source associated with the widespread SEP event is the shock driven by the CME, as the flare observed as a post-eruptive arcade is too late to explain the estimated particle onset. The different intensity-time profiles observed by STEREO-A, located at 0.97 au, and MESSENGER, at 0.33 au, can be interpreted as enhanced particle scattering beyond Mercury’s orbit. The longitudinal extent of the shock does not explain by itself the wide spread of particles in the heliosphere. The particle increase observed at L1 may be attributed to cross-field diffusion transport, and this is also the case for STEREO-B, at least until the spacecraft is eventually magnetically connected to the shock when it reaches ∼0.6 au.
On the critical current for the charge density wave transport
Authors: Sinchenko A. A. , Zybtsev S. G. , Gorlova I. G. , Latyshev Yu. I. , Pokrovskii V. Ya. , Monceau P. 
Published: July 2021

We report transport measurements under very high current densities j, up to 108 A/cm2, of
quasi-one-dimensional charge-density wave (CDW) conductors NbSe3 and TaS3. Above $j_0-10^1$ A/cm2 the point contacts
NbSe3-NbSe3 show a sharp singularity, and the TaS3 nanosamples show metallic temperature dependence (positive
dR/dn. We interpret both results as an evidence for the suppression of the Peierls gap 2A and development of the
metallic state above j0. Possible scenarios of the Peierls state destruction are discussed.