bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brief Report: Higher Fentanyl Exposures Require Higher Doses of Naloxone for Successful Reversals in a Quantitative Systems Pharmacology Model
Authors: Moss Ronald B. , Pryor Meghan McCabe , Baillie Rebecca , Kudrycki Katherine , Friedrich Christina , Reed Mike , Carlo Dennis J 
Published: December 2021

Abstract
Background: Previously, we reported on an opioid receptor quantitative systems pharmacology (QSP) model to evaluate naloxone dosing. Methods: In this study we extended our model to include higher systemic levels of fentanyl (up to 100 ng/ml) and the newly approved 8mg IN naloxone dose (equivalent to 4 mg)Results : As expected, at the lower peak fentanyl concentrations (25 ng/ml and 50 ng/ml), the simulations predicted that 2 mg, 4 mg, 5 mg, and 10 mg IM doses of naloxone displaced fentanyl and reached below the 50% receptor occupancy within 10 minutes. However, at the concentration of 75 ng/ml, the simulation predicted that the 2 mg dose of naloxone failed to reach below the 50% occupancy within 10 minutes. Interestingly, at the highest peak concentration of fentanyl studied (100 ng/ml), the model predicted that the 4 mg of naloxone IM (equivalent to 8 mg IN) failed to reach below the threshold of 50 % occupancy within 10 minutes or even within 15 minutes (Data not shown). In contrast, the model predicted successful reversals when 5 and 10 mg IM doses were utilized. Conclusion:These results support the notion that acutely administered higher doses of naloxone are needed for rapid and adequate clinical reversal, particularly when higher systemic exposure of the potent synthetic opioids occur.
Multi-directional Forging of Large-Scale Mg-9Gd-3Y-2Zn-0.5Zr Alloy Guided By 3D Processing Maps And Finite Element Analysis
Authors: Li Jiyu , Dong Shuai , Zhao Chaoyu , Zeng Jian , Jin Li , Wang Fenghua , Wang Fulin , Dong Jie 
Published: December 2021

Abstract
The three-dimensional (3D) processing maps of cast Mg-9.0Gd-3.0Y-2.0Zn-0.5Zr alloy were established based on isothermal compression tests and dynamic material model (DMM). The stable and power efficient forming domains were determined by considering both the instability and power dissipation efficiency maps. Multi-directional forging (MDF) was then simulated by employing finite element (FE) analysis in the Deform-3D software, using the 3D power dissipation efficiency maps as input. The optimal forging parameters were thus obtained for a large-scale ingot with 430 mm in diameter and 440 mm in height, i.e. a forging temperature of 450 ℃ and forging speed of 10 mm/s. Finally, a Mg-9.0Gd-3.0Y-2.0Zn-0.5Zr cake-shaped forged part with 900 mm in diameter and 100 mm in height was produced. After T6-heat treatment, the edge and center of the forged part exhibit homogeneous microstructure and relatively consistent properties, with the tensile strength, yield strength and elongation being about 400 MPa, 320 MPa and 14.0% respectively. Using transmission electron microscopy, the main strengthening phases were revealed to be the dense nano-scale β' phases that are uniformly distributed inside the material.
Microwave-Assisted Synthesis of the Flexible Iron-Based MIL-88B Metal-Organic Framework for Advanced Energetic Systems
Authors: Zorainy Mahmoud Y. , Kaliaguine Serge , Gobara Mohamed , Elbasuney Sherif , Boffito Daria C. 
Published: December 2021

Abstract
The 3D metal-organic framework (MOF), MIL-88B, built from the trivalent metal ions and the ditopic 1,4-Benzene dicarboxylic acid linker (H2BDC), distinguishes itself from the other MOFs for its flexibility and high thermal stability. MIL-88B was synthesized by a rapid microwave-assisted solvothermal method at high power (850 W). The iron-based MIL-88B [Fe3.O.Cl.(O2C-C6H4 -CO2)3] exposed oxygen and iron content of 29% and 24%, respectively, which offers unique properties as an oxygen-rich catalyst for energetic systems. Upon dispersion in an organic solvent and integration into ammonium perchlorate (AP) (the universal oxidizer for energetic systems), the dispersion of the MOF particles into the AP energetic matrix was uniform (investigated via elemental mapping using an EDX detector). Therefore, MIL-88B(Fe) could probe AP decomposition with the exclusive formation of mono-dispersed Fe2O3 nanocatalyst during the AP decomposition. The evolved nanocatalyst can offer superior combustion characteristics. XRD pattern for the MIL-88B(Fe) framework TGA residuals confirmed the formation of α-Fe2O3 nanocatalyst as a final product. The catalytic efficiency of MIL-88B(Fe) on AP thermal behavior was assessed via DSC and TGA. AP solely demonstrated a decomposition enthalpy of 733 J g-1 , while AP/MIL-88B(Fe) showed a 66% higher decomposition enthalpy of 1218 J g-1 ; the main exothermic decomposition temperature was decreased by 71 °C. Besides, MIL-88B(Fe) resulted in a decrease in AP decomposition activation energy by 23% and 25% using Kissinger and Kissinger–Akahira–Sunose (KAS) models, respectively.
Pseudodesulfovibrio sediminis sp. nov., a Mesophilic and Neutrophilic Sulfate-reducing Bacterium Isolated From Sediment of a Brackish Lake
Authors: Takahashi Ayaka , Kojima Hisaya , Watanabe Miho , Fukui Manabu 
Published: December 2021

Abstract
A novel mesophilic and neutrophilic sulfate-reducing bacterium, strain SF6T, was isolated from sediment of a brackish lake in Japan. Cells of strain SF6T were motile and rod-shaped with length of 1.2–2.5 μm and width of 0.6–0.9 μm. Growth was observed at 10–37°C with an optimum growth temperature of 28°C. The pH range for growth was 5.8–8.2 with an optimum pH of 7.0. The most predominant fatty acid was anteiso-C15 : 0. Under sulfate-reducing conditions, strain SF6T utilized formate, lactate, ethanol and glucose as growth substrate. Chemolithoautotrophic growth on H2 was also observed. Fermentative growth occurred on pyruvate. As electron acceptor, sulfate, sulfite, thiosulfate and nitrate supported heterotrophic growth of the strain. The complete genome of strain SF6T is composed of a circular chromosome with length of 3.8 Mbp and G + C content of 54 mol%. Analyses of the 16S rRNA gene and whole genome sequence indicated that strain SF6T belongs to the genus Pseudodesulfovibrio but distinct form all existing species in the genus. On the basis of its genomic and phenotypic properties, strain SF6T (= DSM111931T = NBRC 114895T) is proposed as the type strain of a new species, with name of Pseudodesulfovibrio sediminis sp. nov.
Utility of Speckle-Tracking Echocardiography For Predicting Atrial Fibrillation Following Ischemic Stroke: A Systematic Review And Meta-Analysis
Authors: Gao Qinggele , Liu Peng , Lv Tingting , Yang Ying , Zhang Ping 
Published: December 2021

Abstract
Purpose: Undiagnosed atrial fibrillation (AF) is one of the main sources of cryptogenic stroke. And strain indices measured by speckle-tracking echocardiography are associated with atrial remodeling supposed to be the substrate of AF. Therefore, there is a strong need for evaluating the utility of speckle-tracking echocardiography to predict the likelihood of AF in patients with cryptogenic stroke.Methods: PubMed, Embase and Cochrane Database were searched for studies. The random-effects model was used to calculate the pooled results, and summary receiver operating characteristic curve (SROC) analysis was performed to show the overall predictive value.Results: There were 1483 patients with cryptogenic stroke from 8 studies. Meta-analysis showed that strain indices including global longitudinal strain (GLS) (mean difference [SMD]: -0.22, 95% confidence interval [95% CI]: -0.40 to -0.04) , left atrial reservoir strain (εR), (SMD: -0.87, 95% CI: -1.26 to -0.48, conduit strain (εCD) (SMD: -0.56, 95% CI: -0.81 to -0.30), contractile strain (εCT) (SMD: -1.00, 95% CI: -1.39 to -0.61), and left atrial reservoir strain rate (SRe) (SMD: -0.54, 95% CI: -0.80 to -0.28) measured at the period of cryptogenic stroke was significantly decreased in patients with AF occurrence compared to without. SROC analysis suggested an acceptable predictive efficiency of εR for AF occurrence (AUC = 0.799).Conclusion: For patients after cryptogenic stroke, GLS, εR, εCD, εCT and SRe were significantly decreased in AF occurrence compared with non-occurrence. But there was no value in left atrial reservoir strain rate (SRs) and contractile strain rate (SRa) for predicting AF.
Microbial Communities Associated With Stunted Growth Syndrome In Penaeus Vannamei Farming
Authors: Jangam Ashok Kumar , Nathamuni Suganya , Katneni Vinaya Kumar , Avunje Satheesha , Angel Raymond Jani , Grover Monendra , Shekhar Mudagandur Shashi 
Published: December 2021

Abstract
Purpose: Stunted/slow growth syndrome is one of the yield-limiting diseases in Penaeus vannamei farming. Limited information is available on the aetiology of this condition, which needs to be studied to devise prophylactic measures to minimise the production losses. Amongst the factors that influence this condition, microbial communities in the growing environment play an important role. This study aimed at understanding major microbial associations of affected and healthy pond waters through shotgun metagenomics.Method: The water samples were filtered through vacuum filtration to extract suspended microbes. Subsequently, DNA was isolated from the filtrate using PowerSoil® DNA Isolation Kit. Libraries prepared from isolated DNA were sequenced using the shotgun metagenomic method on the Illumina HiSeq platform. The microbial profiling and their functional prediction of the shotgun metagenome sequences were carried out using stand-alone versions of Kaiju, OmicsBox respectively. Results: The taxonomic classification results revealed that species of Oceanospirillum, and vibrio were high in the disease sample, while Rhodobacteraceae bacterium and Neptunomonas were high in the healthy sample. The alpha diversity analysis showed slightly higher diversity in the healthy sample compared to the disease infected. The taxonomic biomarkers for healthy and infected states reported in previous studies were also observed in this study. The major functional associations of both the healthy and infected groups include amino acid transport and metabolism, cell wall/membrane/envelope biogenesis, and energy production and conversion. Conclusion: The study identified major taxonomical and functional associations of ponds affected and unaffected with stunted growth syndrome. These associations significantly varied between the samples, indicating dysbiosis of the microbial profiles in the pond waters. This dysbiosis could be a potential cause for the manifestation of stunted growth syndrome. Microbial associations along with other pond environmental factors need to be further explored for an in-depth understanding of stunted growth syndrome.
Clinical Application of a Modified Local Transposition Flap Surgery in Repairing Fingertip Defects
Authors: Zhang Yingkai , Wang Yao , Wu Rongbo , Zhou Jiaqi 
Published: December 2021

Abstract
Background: A modified local transposition flap surgery was performed for fingertip injuries, which allows a more significant transfer distance with good outcomes.Methods: The study collected patients who underwent parallelogram transposition flaps and V-Y flaps to repair fingertip defects from 2017 to 2020. 122 cases (122 fingers) were included in our study, The interval between the injury and operation was 5.78 h (the mean value was 4.7-8.4 h). All operations were performed by one surgical team, and the average operation time was 31.2 min.Record the operation time，two-point discrimination（2PD），Total Active Movement (TAM)and the MHQ (Michigan Hand Questionnaire) of the injured fingers to evaluate the therapeutic effect.Results: All parallelogram （Group A）and V-Y flaps （Group B）had survived postoperatively. There was no difference with operative duration and follow-up time in two groups. At last follow-up, there was no difference with the 2PD of the palmar part of the flaps and the TAM of injured figures in Group A and Group B . The MHQ summary scores in Group A were much higher than in Group B . Evaluation of the MHQ subscale performance showed that the overall hand function, activities of daily living, work performance and pain score had no differences, but aesthetics and satisfaction score was higher in Group A .Conclusions: The reconstruction using parallelogram flaps is a easier and more versatile treatment with better functions, less morbidity and better aesthetics. This method is a better choice for reconstruction of fingertip injury.
Long-term culture expanded alveolar macrophages restore full epigenetic identity in vivo
Authors: Subramanian Sethuraman , Busch Clara , Molawi Kaaweh , Geirsdottir Laufey , Maurizio Julien , Vargas-Aguilar Stephanie , Belahbib Hassiba , Gimenez Gregory , de Laval Bérengère , Yuda Ridzky , Burkon Michaela , Najjar Sara Gholamhosseinian , Kandalla Prashanth Kumar , Sarrazin Sandrine , Alexopoulou Lena , Favret Jérémy , Sieweke Michael 
Published: December 2021

Abstract
Alveolar macrophages (AM) are tissue resident macrophages of the lung that can be expanded in culture, but it is unknown to what extent culture affects their in vivo identity. Here we show that long-term ex vivo expanded mouse AM (exAM) maintain core AM gene expression but show culture adaptations related to adhesion, metabolism and proliferation. Strikingly, even after several months in culture exAM reacquired full transcriptional and epigenetic identity upon transplantation into the lung and could self-maintain in the natural niche long-term. Changes in open chromatin regions (OCR) observed in culture were fully reversible in transplanted exAM (texAM) and resulted in a gene expression profile indistinguishable from resident AM. Our results demonstrate that long-term proliferation of AM in culture does not compromise cellular identity in vivo. The demonstrated robustness of exAM identity provides new opportunities for mechanistic analysis and highlights the therapeutic potential of ex vivo expanded macrophages.
Simultaneous Bicompartmental Bucket Handle Injury Associated With a Chronic Anterior Cruciate Ligament Rupture: Case Report and Literature Review
Authors: Buljubasich Martin , Garcia-Mansilla Agustin Maria , Bistolfi Mariano Garcia , Astoul Juan , Paz Matias Costa , Vestri Renato 
Published: December 2021

Abstract
Introduction: Simultaneously locked bucket handle injury of both menisci is a rare phenomenon. Clinically the knee is locked in flexion with pain in both joint lines. It has a high association rate with instability generated by an anterior cruciate ligament injury (ACL). There are a few reports regarding this association or without any associated injury treated either in one-stage or two-stage surgery.Objetive: To report a patient with a simultaneous bicompartmental locked bucket handle, highlighting the challenges of the surgical technique and a literature review.Case Report: We present the case of a 42-year-old male with a simultaneous bicompartmental locked bucket handle injury associated with chronic ACL deficiency. Treated in one stage by bilateral partial meniscectomy and ACL reconstruction. We discuss the MRI findings, treatment options and performed an up-to date review.Conclusions: Although partial meniscectomy is a common procedure, when performed in an unusual patient and in the absence of therapeutic guidelines or consensus when dealing with this association, an appropriate preoperative plan should be followed. This case provides a perioperative approach focused on a review of the most recent literature.
Organizational networks and sustainable urban water practices in US local governments
Authors: Pivo Gary , Henry Adam Douglas , Berger Lena , Gomez-Fernandez Edna Liliana 
Published: December 2021

AbstractOrganizational networks are regarded as key in policy innovation for sustainable development. They are thought to enhance innovation through access to first-hand experience, enhanced trust within a community, and exposure to role models and competitors. Despite theoretical pertinence, organizational networks have not been studied as much as other drivers of innovation, such as organizational capacity, leadership, and the socio-political environment. This empirical study explores how networks affect the implementation of Sustainable Urban Water Management Practices (SUWM) at the local level. Using data from 110 local governments in five US regions, we examine the relationship between social interaction and the implementation of SUWM, and how this relationship depends on the types of interaction partners. Our findings show that local governments with larger organizational networks implement more SUWM practices. Collaboration with non-governmental organizations, particularly water sector associations, is strongly associated with an increase in use of SUWM practices. Overall, our findings suggest that creating and maintaining a robust organizational network of other government agencies and non-governmental organizations, especially water sector associations, increases the chances that a local government will implement more SUWM practices.
Enhanced desalination efficiency of flow-through capacitive deionization cell by mesh electrode with granular aerogel carbon in the removal of ions from synthetic and real samples
Authors: Roshan Bahram , Rasoulzadeh Hassan , Massoudinejad Mohamadreza , Saadani Mohsen , Sanaei Daryoush 
Published: December 2021

Abstract
Flow-through capacitive deionization (FTCDI) is a traditional improved flow-by CDI cellular structure, used to remove ions from aqueous solutions. In this study, a new FTCDI was designed consisting of mesh electrodes (ME) containing ion-exchange membranes (IEM) and aerogel carbon granules with a specific surface area of 489 m2/g. All analyses and experiments performed showed that the new design can remove nitrate, phosphate, sodium, calcium, and chloride. Under optimal conditions, the new FTCDI system can remove 82.5, 49, 85, and 90% of sodium chloride, calcium chloride, nitrate, and phosphate with a maximum input concentration of 450 mg/L, 450 mg/L, 70 mg/L, and 3 mg/L, respectively. The efficiency of this system was also evaluated for real samples. Findings of the study showed that if the initial amount of turbidity is 12 NTU, total soluble solids (TDS) 1,700 mg/L, total hardness 540 mg/L, phosphate 0.09 mg/L, nitrate 28.8 mg/L, and electrical conductivity (EC) 3,480 μs/cm, the system can remove 25, 23.5, 33.3, 66.6, 54.4, and 39.1%, respectively.
Association between Estimated Cardiorespiratory Fitness and Depression among Middle-income Country Adults: Evidence from National Health Survey
Authors: Lattari Eduardo , Pascouto Andreza Jesus Costa , Oliveira Bruno Ribeiro Ramalho , Silva Livia Soares , Oliveira Aldair José , Machado Sérgio , Neto Geraldo Albuquerque Maranhao 
Published: December 2021

Objective:
This study assessed the relationship between cardiorespiratory fitness (CRF) and depression in adults.

Methods:
A total of 52,611 individuals aged between 18-59 years old were evaluated for symptoms of depression and CRF. The presence of depressive symptoms was self-report through the Patient Health Questionnaire (PHQ-9), and the CRF was predicted from a non-exercise equation. The association between CRF and the presence of depression was determined by crude and multivariable-adjusted logistic regressions.

Results:
The associations were identified between symptoms of depression and CRF in both unadjusted and adjusted models. After adjusting for age categories, sex, body mass index categories, educational level, marital status, smoking, and alcohol use, the individuals with moderate CRF had 18% lower odds of depression (OR: 0.82, CI 95%: 0.71 – 0.95) compared to individuals with low CRF.

Conclusion:
Depressive symptoms are inversely related to CRF levels in adults.
Patterns and Predictors of Internet Gaming Disorder: An Observational Study from Jordan
Authors: Karasneh Reema , Al-Azzam Sayer , Alzoubi Karem H. , Nusair Mohammad B. , Hawamdeh Sahar , Nusir Amal T. 
Published: December 2021

Objective:Internet Gaming Disorder (IGD) is a rapidly growing public health problem that may have detrimental effects. The purpose of this study is to identify factors associated with IGD status.Methods:In this cross-sectional observational study, a convenient sample of gamers in Jordan was recruited and asked to participate in an online survey based on the nine criteria of the 20-item Internet Gaming Disorder (IGD-20) used to assess gaming disorder. Sociodemographic and psychosocial data were also obtained.Results:A total of 504 gamers participated in this study. The mean age of respondents was 21.6 ± 3.90 years. Using the standard IGD-20 scale, 96 participants (19%) were classified as potential IGD cases, compared to 408 (80.9%) non-disordered gamers. Males were dominant among the population, constituting 348 (69%) of gamers. Males also played significantly more hours per week [17.8 ±16.75] compared to females [13 ± 17.65]. The majority of gamers (411 (81.5%)) were students, although unemployed adults played for the highest total time [23.9 ± 30.84 hours/week]. Device type used for gaming also significantly (p <0.05) affected the time spent playing. Predictors of IGD included educational level (p< 0.05) and playing hours/week (p< 005). Conversely, no significant associations were found between IGD and gender, age, employment, or sleeping hours. IGD is increasingly being diagnosed among both genders and presents a health challenge for internet users.Conclusion:Establishing gamer profiles and recognizing predictors of IGD is therefore vital for guiding clinical classification and diagnosis of the disease.
CHANGING AGRICULTURAL PRACTICES AND IT’S SOCIAL AND ENVIRONMENTAL INFLUENCES
Authors: Trivedi Reena 
Published: December 2021

Agricultural technology advancements are continuously taking place in India, as the progress of agricultural sector directly impacts a major proportion of population and its living condition. Farmers are interested to adopt new inventions and technologies in agriculture.	Modern agricultural practices are significantly affecting human health and environment. The release of greenhouse gases such as carbon dioxide, methane and nitrous oxide are adversely affecting biodiversity and increasing air, water and soil pollution. Agricultural residue management, use of pesticides and insecticides, inorganic manure, chemical fertilizers leads to harmful effect on human health and increasing environmental pollution. Recent agriculture trends emphasizes on enhancing agricultural production in terms of quantity in less time, overlooking its adverse affects. In this paper we have analyzed the negative effects of modern agricultural practices on human health and environment. It leads to decline in soil fertility, loss of biodiversity, climate change, air, water and soil pollution, environmental degradation etc. Our farmers are now adopting modern agricultural techniques, using chemical fertilizers, pesticides, insecticides, expanding irrigation facilities, using high yielding varieties of seeds, modern machines, varying crop sequences etc. But these efforts of expanding food supply in less time is taking place at the cost of human health and environment degradation. Spray of harmful chemicals on crops not only pollutes underground water and air but also bad for human and animal health. Non harmonious, unwise and unsustainable agricultural practices have a considerable impact on environment and also harmful for living beings.