bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical evaluation of endoscopic biliary stenting in treatment of malignant obstructive jaundice
Authors: Wang Wei , Zhang Chao , Li Bing , Yuan Ge-Yi-Lang , Zeng Zhi-Wu 
Published: December 2024

BACKGROUND
Malignant obstructive jaundice (MOJ) is characterized by the presence of malignant tumors infiltrating or compressing the bile duct, causing poor bile drainage, generalized yellowing, pain, itching, and malaise. MOJ is burdensome for both the society and the families of affected patients and should be taken seriously.
AIM
To evaluate the clinical effect of stent placement during endoscopic retrograde cholangiopancreatography for relieving MOJ and the efficacy of percutaneous transhepatic biliary drainage in terms of liver function improvement, complication rates, and long-term patient outcomes.
METHODS
The clinical data of 59 patients with MOJ who were admitted to our hospital between March 2018 and August 2019 were retrospectively analyzed. According to the treatment method, the patients were divided into an observation group (29 patients) and a control group (30 patients). General data, liver function indices, complications, adverse effects, and 3-year survival rates after different surgical treatments were recorded for the two groups.
RESULTS
There were no significant differences in baseline information (sex, age, tumor type, or tumor diameter) between the two groups (P > 0.05). Alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels were significantly better in both groups after surgery than before surgery (P < 0.05). The overall incidence of biliary bleeding, gastrointestinal bleeding, pancreatitis, and cholangitis was 6.9% in the observation group and 30% in the control group (P < 0.05). No significant differences in the rates of blood transfusion, intensive care unit admission, or death within 3 years were observed between the two groups at the 1-month follow-up (P > 0.05). The 3-year survival rates were 46.06% and 39.71% in the observation and control groups, respectively.
CONCLUSION
Endoscopic biliary stenting effectively relieves MOJ and significantly improves liver function, with minimal complications. This technique is a promising palliative approach for patients ineligible for radical surgery. However, further research is needed to optimize current treatment strategies and to explore their potential in treating nonmalignant cases of obstructive jaundice.
Petersen's hernia with chylous ascites following laparoscopic total gastrectomy and Roux-en-Y anastomosis: A case report and review of literature
Authors: Hu Shi-Fu , Hao Yuan-Yuan , Liu Xiang-Yu , Liu Han-Bo 
Published: December 2024

BACKGROUND
Petersen’s hernia occurring through the epiploic foramen of the greater omentum, is an uncommon type of internal hernia. When it presents with complications such as chylous ascites, which is the lymphatic fluid accumulation in the abdominal cavity, it is particularly rare. Following laparoscopic total gastrectomy and Roux-en-Y anastomosis, the incidence of this condition is exceedingly low.
CASE SUMMARY
A 62-year-old male patient developed Petersen’s hernia following laparoscopic total gastrectomy (LTG) for gastric cancer, after Roux-en-Y anastomosis. Intestinal torsion and obstruction were experienced by the patient, along with a small amount of chylous ascites. Imaging studies and clinical assessment confirmed the diagnosis. Emergency surgery was performed promptly for the patient in the operating room. The twisted small intestine was reduced and the defect in Petersen’s space was repaired. The procedure was successful in the correction of the intestinal torsion and approximation of the hernia without the need for bowel resection. The patient’s condition significantly improved following the surgery. The ascites evolved from a milky white appearance to a pale yellow, with a substantial decrease in the triglyceride levels in the ascitic fluid, implying a favorable recovery trajectory. The patient was monitored closely and received appropriate care postoperatively, including nutritional support and fluid management.
CONCLUSION
This report illustrates the significance of recognizing Petersen’s hernia as a potential complication following gastrectomy for gastric cancer. It highlights the fundamental role of early surgical intervention in the effective management of such complications. The favorable outcome in this patient illustrates that prompt and appropriate surgical management can deter the necessity for more extensive procedures such as bowel resection.
Five-year complete remission of super-giant hepatocellular carcinoma with hepatectomy followed by sorafenib plus camrelizumab: A case report
Authors: Zheng Xiao-Qin , Sun Li-Bo , Jin Wen-Jie , Liu Hui , Song Wen-Yan , Xu Hui , Wu Ju-Shan , Wang Xiao-Jun , Gou Chun-Yan , Ding Hui-Guo 
Published: December 2024

BACKGROUND
Cirrhotic patients with super-giant hepatocellular carcinoma (HCC) and portal vein invasion generally have a poor prognosis. This paper presents a patient with super-giant HCC and portal vein invasion, who underwent hepatectomy followed by a combination of sorafenib and camrelizumab, resulting in complete remission (CR) for 5 years.
CASE SUMMARY
A 40-year-old male with compensated hepatitis B-related cirrhosis was diagnosed with HCC, Barcelona Clinic Liver Cancer stage C. Enhanced computed tomography imaging revealed a 152 mm × 171 mm tumor in the right liver, invading the portal vein and hepatic vein. Liver function was normal. The patient successfully underwent hepatectomy on July 18, 2019. However, by December 2019, HCC recurrence with lung metastases and portal vein invasion were detected. He started treatment with sorafenib (200 mg twice daily) and camrelizumab (200 mg every 3 weeks). By May 12, 2020, the patient was confirmed to have CR. Camrelizumab was adjusted to 200 mg every 12 weeks from June 16, 2021, with the last infusion on March 29, 2024. Although no further tumor recurrence was observed, he experienced two episodes of gastrointestinal bleeding due to esophagogastric varices, which were managed with endoscopic therapy. To date, the patient has remained in CR for 5 years.
CONCLUSION
The combination of hepatectomy with sorafenib and camrelizumab can achieve durable CR in patients with super-giant HCC and portal vein invasion. Further research is necessary to address these challenges and improve patient outcomes.
DESTINATION BRANDING FOR GAINING A COMPETITIVE EDGE IN THE GLOBAL TOURISM LANDSCAPE: INSIGHTS AND PROSPECTS OF THE GEORGIAN CASE
Authors: Abashidze Irakli 
Published: December 2024

Irakli Abashidze
E-mail: irakli.abashidze02@gruni.edu.ge
Doctor of business administration, associate professor Grigol Robakidze University
Batumi, Georgia
https://orcid.org/0000-0002-0011-6279

Abstract: Destination branding with its role in the international tourism landscape is a constantly evolving field of study. Effective branding can propel a country forward, significantly contributing to its economic development. Achieving success in this area necessitates meticulous planning and execution of marketing campaigns. However, increasing competition and global fluctuations highlight the need for comprehensive research to inform the practical implementation of successful destination branding strategies.
In the post-pandemic period, the global tourism landscape has shifted, presenting both challenges and opportunities for countries aiming to strengthen their destination brands. COVID-19 has redefined traveler preferences, with heightened emphasis on safety, authenticity, and experiential tourism. As countries like Georgia seek to establish a resilient position in the tourism market, adapting destination branding strategies to align with these evolving preferences is essential. The pandemic has also brought about a surge in digital engagement, offering new avenues for countries to reach and engage target audiences through online platforms. Additionally, in a post-COVID world, Georgia has the opportunity to differentiate itself by focusing on niche tourism sectors that align with emerging global travel trends. These shifts underscore the importance of crafting flexible and responsive branding approaches that can adapt to rapid changes, thereby providing a competitive edge in the international tourism arena.
The objective of this paper is to investigate destination branding, using Georgia as a case study in the post-pandemic period, to explore trends and insights with a focus on competition. Through literature review and observation, various aspects of the issue are analyzed, resulting in conclusive recommendations for enhancing Georgia’s competitive advantage as a destination brand.

Keywords: Destination branding, Tourism marketing, Georgia

JEL classification: M31
THE ROLE OF KNOWELDGE MANAGEMENT IN IMPROVING THE QUALITY OF HIGHER EDUCATION SERVICES ACCORDING TO THE SERVEQUAL MODEL: “CASE STUDY OF HIGHER SCHOOL OF MANAGEMENT TLEMCEN”
Authors: Brahimi Assia , Benabdallah Awicha , Benserir Mohamed , Batouche Mohamed 
Published: December 2024

Assia Brahimi
E-mail: bra.assia@gmail.com
Lecturer A, Higher School of Management Tlemcen, LEREMA laboratory
Algeria
https://orcid.org/0009-0009-2816-6428

Awicha Benabdallaha
E-mail: benabdallah333@yahoo.co.uk
Lecturer A, Higher School of Management Tlemcen, LEREMA laboratory
Algeria
https://orcid.org/0009-0001-2329-078X
Mohamed Benserir
E-mail: Mohamedbenserir1997@hotmail.com
Master student, Higher School of Management Tlemcen
Algeria
Mohamed Batouche
E-mail: Mohamedbatouche96@gmail.com
Master student ,Higher School of Management Tlemcen
Algeria

Abstract: This study aimes at showing the role of knowledge management processes in improving the quality of higher education services according to the servequal model at the Higher School of Management Tlemcen. Thus, a descriptive analytical approach was used to check the impact of the independent variable on the dependent variable in the light of the hypotheses of the study. Data collection process was undertaken through the distribution of a questionnaire administered to all professors working in the school, numbering (65) professors, while the study sample included (48 professors), and after using the statistical program SPSS to process and analyze data, results revealed a positive and statistically significant relationship between knowledge management processes and the improvement of the quality of higher education services at the Higher School of Management Tlemcen.

Keywords: Knowledge, Knowledge Management, Quality of Higher Education, Servequal Model, Higher School of Management Tlemcen

JEL classification: I24; D83
Soviet Monuments in Urban Space: Reformatting the Past
Authors: Artamonov Denis S. 
Published: December 2024

The article is devoted to the problem of transformation of the role of Soviet monuments in modern urban space. The author examines the changes in their perception in the context of cultural, social and political processes, and also shows how monuments are used as an arena for memorial conflicts. Special attention is paid to the loss of their memorial significance and their inclusion in individual and folklore practices reflecting changes in the identity of society. The purpose of the study is to analyze the mechanisms of reformatting Soviet monuments, their symbolic significance and influence on collective memory. As a result, the author proves that monuments originally created to promote ideological values acquire new symbolic functions over time. In modern conditions, they often lose their original commemorative role, becoming elements of urban folklore, tourist sites or even the basis for Internet content. In addition, their transformation, associated with physical changes or recoding of meanings, turns monuments into a tool for rethinking the past and expressing modern identity. It is noted that Soviet monuments are becoming objects of memorial conflicts, especially in post-Soviet countries, where changes in memory policy cause discussions in society. The conclusions of the article will be useful to researchers engaged in the study of memory, cultural policy and urbanism, as well as to anyone interested in the history of the Soviet heritage. The article emphasizes the importance of rethinking the past in shaping the modern urban environment and identity.
PERAN GURU PENDIDIKAN PANCASILA DALAM MEMBENTUK PROFIL PELAJAR PANCASILA PESERTA DIDIK DI SMP GUNUNGJATI 1 PURWOKERTO
Authors: Wulandari Nessya , Kartikawati Ratna , Faridli Efi Miftah 
Published: December 2024

Penelitian ini bertujuan untuk menganalisis peran guru pendidikan pancasila dalam membentuk profil pelajar pancasila peserta didik di SMP Gunungjati 1 Purwokerto dan mengetahui kendala yang dihadapi guru Pendidikan Pancasila dalam membentuk profil pelajar pancasila peserta didik di SMP Gunungjati 1 Purwokerto serta upaya yang dilakukan untuk mengatasi kendala yang dihadapi guru pendidikan pancasila dalam membentuk profil membentuk profil pelajar pancasila peserta didik di SMP Gunungjati 1 Purwokerto. Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif. Teknik pengumpulan data meliputi observasi, wawancara, studi dokumentasi, dan studi literatur. Adapun subjek di dalam penelitian ini adalah WAKA Kesiswaan, Guru Pendidikan Pancasila, dan Peserta didik kelas 7. Analisis data yang digunakan oleh peneliti menggunakan tahapan reduksi data, display data, dan penarikan kesimpulan. Hasil penelitian menunjukan bahwa : 1) Peran guru yaitu guru memberikan pengetahuan, menjawab pertanyaan siswa, menginfokan terkait pelanggaran dan menjadi contoh dengan tidak melakukan hal negatif, guru mengharuskan siswa belajar giat serta guru menilai dan memberi komentar. 2) Kendala yang dihadapi guru yaitu anak kurang semangat dalam pembelajaran, sebagian siswa tidak mau mengerjakan tugas, siswa tidak mau mendengarkan, dan siswa tidak paham sehingga hanya sebagian siswa yang bernalar kritis. 3) Upaya yang dilakukan guru untuk mengatasi kendala yaitu pemberian tugas bervariasi, model pembelajaran menarik, dan guru harus menjelaskan materi secara detail supaya siswa paham. sehingga memicu siswa untuk bernalar kritis.
Exploration of Sustainable Development Goals (SDGs) of Industrial Heritage Sites in China's Third Front Construction Under the Vision of Cultural and Tourism Integration Taking the Landscape Design of Liuhe Silk Factory in Nanchong City, China as an Example
Authors: Xiaoyi Yang , Boonyanmethaporn Watsida 
Published: December 2024

Objective: This paper explores the sustainable development purpose of industrial heritage landscape design in China through industrial heritage landscape design.

Theoretical Framework: This study draws on relevant literature, including two parts: theory and practice cases, such as the review of landscape design cases and the impact of landscape design theoretical framework on the sustainable development of industrial heritage sites.

Method: The method adopts a case study approach. It reviews the landscape design process of the Liuhe Silk Factory, compares the data collected before and after construction, and thus concludes that sustainable development can be achieved through landscape design.

Results and Discussion: The study's results reveal that to achieve the sustainable development purpose of industrial heritage, landscape design requires innovative design concepts and highlights the importance of integrating culture and tourism.

Research Implications: This study's results have practical significance for the development of industrial heritage landscape design in China and even in developing countries and contribute to the realization of the Sustainable Development Goals (SDGs).

Originality/Value: This study provides new insights into realizing sustainable development goals for industrial heritage and finds a landscape design method that contributes to the literature and has the potential to be applied in tourism and cultural heritage management.
Anal fissures in COVID-19 survivors: Incidence, risk factors, and outcomes
Authors: Sakr Ahmad , Hesham Yousef , Elfeki Hossam , Shalaby Mostafa , Hossam Elfallal Ahmed , Sameer Amr 
Published: December 2024

Objective: In spite of COVID-19’s typical presentation in the form of fever, cough, myalgia, and pneumonia, other gastrointestinal manifestations have been reported. Among the COVID-19 survivors, anal fissure has been documented. The aim of this study was to report the incidence of anal fissure among those patients, its possible risk factors and outcome.
Material and Methods: This is a retrospective cross-sectional study which was conducted on COVID-19 patients’ who were diagnosed with anal fissure. Those who survived and were discharged home safely were contacted to pick up whether they suffered from any symptoms suggesting anal fissure, to identify the risk factors of anal fissure and their outcomes.
Results: A total of 176 COVID-19 patients were enrolled in this study. The incidence of anal fissure among all patients was 36.9%. Patients were categorized into two groups; fissure and non-fissure groups. No significant difference was noted in the demographic data apart from age, which was younger in the fissure group. The majority of anal fissures resolved spontaneously after patients recovered from the COVID-19 symptoms with no specific treatment (43.1%).
Conclusion: Anal fissure is quite a common problem in COVID-19 patients. Young and middle-aged patients are more vulnerable to develop anal fissure after COVID-19 infection.
HER2 immunohistochemical expression and its association with clinicopathological features of gastric adenocarcinoma in Uganda
Authors: Kahiye Mohamed , Yahaya James , Kalungi Sam , Nalwoga Hawa 
Published: December 2024

Objective: Despite the remarkable improvement in gastric adenocarcinoma treatment modalities, the prognosis of gastric adenocarcinoma remains poor. The purpose of this study was to determine the prevalence of HER2 immunohistochemical expression and its association with clinicopathological features of patients with gastric adenocarcinoma.
Material and Methods: This was a cross-sectional study which was conducted at the department of pathology. A total of 86 formalin fixed paraffin embedded tissue blocks of the patients who were confirmed histologically with gastric adenocarcinoma from January 2009 to December 2019 were included in the analysis. Laboratory requisition form and patients’ files were used to extract the clinical and pathological data of the cases. Immunohistochemistry to assess HER2 overexpression was done using monoclonal (SP3 clone) rabbit anti-HER2/neu (Thermo Fisher Scientific-USA). Chi-square statistical test was used to determine the association of the clinicopathological characteristics with HER2 expression. P< 0.05 was considered statistically significant.
Results: Mean age of the patients included in the study was 58.5 ± 14.3 years, and over half 54.7% (n= 47) of the patients were males. Poorly cohesive non-signet ring types contributed most (47.7%) (n= 41) of the cases, and diffuse/mixed histological subtypes were more prevalent (57%) (n= 49) subtypes. Poorly differentiated cases accounted for the majority (66.3%) (n= 57) of the cases. The prevalence of HER2 immunohistochemical expression was 8.1% (n= 7). None of the clinicopathological characteristics were associated with HER2 expression.
Conclusion: This study has shown almost every one in 10 patients with gastric adenocarcinoma may express HER2 when using immunohistochemistry test. However, the HER2 in this study was not associated with age, sex, tumor location, the nature of biopsy, histological subtypes, and tumor grade.
Antimicrobial effects of grapefruit seed extract microfibers against mouse hepatitis virus, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa
Authors: Goto Kazuo , Kiriya Mitsuo , Kakuma Sillow , Horikoshi Kazunori , Suzuki Koichi 
Published: December 2024

Grapefruit seed extract (GSE), which contains flavonoids, possesses antibacterial, antiviral, and antifungal properties. This study investigated the antimicrobial activity of cellulose-bound GSE microfibers against mouse hepatitis virus (MHV) for three weeks and against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa for one week. The disinfectant was smeared on a petri dish to inactivate the MHV for three weeks or to prevent the growth of the selected bacteria for one week. As the disinfectant effect lasted at least one week, GSE microfibers could have applications in disinfecting laboratory animal facilities. The virus or bacteria mixed with the disinfectant did not cause cytopathic effects in the cells or growth on the media after one week.
Reproducible and stable surgical hypertension using a smaller renal artery clip model in Wistar rats
Authors: Abdurahman Syed , Priya Sangh , Peddha Muthukumar Serva 
Published: December 2024

Animal models of hypertension are crucial for studying the pathophysiology of diseases and developing new treatments. This study introduces a reproducible technique for inducing surgical renovascular hypertension in rats using a smaller renal artery clip. The surgical groups were compared to the control group and standard drug group to assess the effectiveness of the surgical model and its stability for 21 days. The results revealed a progressive increase in systolic and diastolic blood pressure in the surgical group. Moreover, the heart rate and body weight in the renal hypertension group demonstrated a sustained elevation at the end of 21 days. These findings confirm the efficacy of this surgical model in inducing hypertension. This surgical animal model is helpful for studying physiological parameters for investigating potential therapeutic interventions against hypertensi