bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nutrition in Skin Picking Disorder and Trichotillomania
Authors: Grant Jon E. , Valle Stephanie , Chamberlain Samuel R. 
Published: November 2021

Objective: Excessive calorie intake constitutes a global public health concern, due to its associated range of untoward outcomes. Impulsivity and compulsivity have been linked to dietary intake. However, nothing is known about dietary intake and body-focused repetitive behaviors, despite their classification as obsessive-compulsive related conditions, and high co-morbidity with impulsive and compulsive conditions.Methods: One hundred and ninety six adults with trichotillomania or skin picking disorder were recruited. Dietary intake over the preceding year was quantified using the Dietary Fat and Free Sugar Short questionnaire. Relationships between dietary fat/sugar intake and behaviors were evaluated using regression modeling.Results: Sugar intake was significantly related to higher trans-diagnostic compulsivity (p = 0.011) and higher non-planning impulsivity (p = 0.013) In terms of saturated fat intake, there was no significant relationship to the explanatory variables. A combination high fat/high sugar diet was significantly associated with higher motor impulsivity (p = 0.005).Conclusions: Past-year nutrition appears to be significantly associated with trans-diagnostic impulsivity and compulsivity. The role of poor nutrition in these disorders and related conditions, and its link with impulsivity and compulsivity, requires longitudinal research attention; and clinical work should address not only psychiatric symptoms but also impact of lifestyle of overall health.
The Relationship Between Cognitive Dysfunction Through THINC-Integrated Tool (THINC-it) and Psychosocial Function in Chinese Patients With Major Depressive Disorder
Authors: Han Han , Hou Yanyan , Yao Shuqiao , Hu Shaohua , Zhou Qi , Yu Xin , McIntyre Roger S. , Shi Chuan 
Published: November 2021

Background: Herein, we validate the psychometric properties of the Chinese version of the THINC-integrated tool (THINC-it) as a screening tool for cognitive deficits in patients with major depressive disorder. The primary aim of this study is to determine whether cognitive deficits as detected by the THINC-it tool in adults with major depressive disorder (MDD) are associated with workplace productivity and/or psychosocial function.Methods: Subjects aged 18–65 (n = 91) with MDD were evaluated and compared to age-, sex- and education- matched healthy controls (n = 95). Symptoms of cognitive dysfunction, workplace productivity, and psychosocial function were measured using the THINC-it tool, Hamilton Depression Scale (HAMD), Sheehan Disability Scale (SDS), The Work Productivity and Activity Impairment questionnaire- Specific Health Problem (WPAI-SHP).Results: There were significant differences in THINC-it scores (p &lt; 0.01), the average of HAMD total score (p &lt; 0.01) and all aspects of SDS (p &lt; 0.01) between two groups. There were significant differences in the four aspects of WPAI between the two groups in the employed status (p &lt;0.01). THINC-it subjective cognition and SDS total score, SDS work/school, SDS social, SDS family showed significantly correlation (r ranging from 0.255 to 0.386, p &lt;0.01). SDS and THINC-it Objective cognition, THINC-it comprehensive cognition were no correlation between two groups. HAMD total score and SDS total score, SDS social, SDS family showed significantly correlation (r ranging
Impact of the COVID-19 Pandemic on Cancer Researchers in 2020: A Qualitative Study of Events to Inform Mitigation Strategies
Authors: Fox Louis , Beyer Katharina , Rammant Elke , Morcom Esme , Van Hemelrijck Mieke , Sullivan Richard , Vanderpuye Verna , Lombe Dorothy , Tsunoda Audrey Tieko , Kutluk Tezer , Bhoo-Pathy Nirmala , Pramesh Shanmugham C. , Yusuf Aasim , Booth Christopher M. , Shamieh Omar , Siesling Sabine , Mukherji Deborah 
Published: November 2021

Introduction: The COVID-19 pandemic has had an unprecedented impact on global health systems and economies. With ongoing and future challenges posed to the field due to the pandemic, re-examining research priorities has emerged as a concern. As part of a wider project aiming to examine research priorities, here we aimed to qualitatively examine the documented impacts of the COVID-19 pandemic on cancer researchers.Materials and Methods: We conducted a literature review with the aim of identifying non-peer-reviewed journalistic sources and institutional blog posts which qualitatively documented the effects of the COVID-19 pandemic on cancer researchers. We searched on 12th January 2021 using the LexisNexis database and Google, using terms and filters to identify English-language media reports and blogs, containing references to both COVID-19 and cancer research. The targeted search returned 751 results, of which 215 articles met the inclusion criteria. These 215 articles were subjected to a conventional qualitative content analysis, to document the impacts of the pandemic on the field of cancer research.Results: Our analysis yielded a high plurality of qualitatively documented impacts, from which seven categories of direct impacts emerged: (1) COVID measures halting cancer research activity entirely; (2) COVID measures limiting cancer research activity; (3) forced adaptation of research protocols; (4) impacts on cancer diagnosis, cases, and services; (5) availability of resources for cancer research; (6) disruption to the private sector; and (7) disruption to supply chains. Three categories of consequences from these impacts also emerged: (1) potential changes to future research practice; (2) delays to the progression of the field; and (3) potential new areas of research interest.Discussion: The COVID-19 pandemic had extensive practical and economic effects on the field of cancer research in 2020 that were highly plural in nature. Appraisal of cancer research strategies in a post-COVID world should acknowledge the potential for substantial limitations (such as on financial resources, limited access to patients for research, decreased patient access to cancer care, staffing issues, administrative delays, or supply chain issues), exacerbated cancer disparities, advances in digital health, and new areas of research related to the intersection of cancer and COVID-19.
The Influencing Factors of Nutrition and Diet Health Knowledge Dissemination Using the WeChat Official Account in Health Promotion
Authors: Bian Dongsheng , Shi Yongmei , Tang Wenjia , Li Dong , Han Kangni , Shi Chenshu , Li Guohong , Zhu Fan 
Published: November 2021

Background: The promotion of a healthy diet via health education is a component of the “Healthy China 2030” plan. However, few studies have reported whether health knowledge about nutrition and diet has gained public attention, and whether it is needed by the public.Methods: The numbers of views, shares, and reads of articles published by the official WeChat account of a hospital in China were accessed. The influence index was obtained via the entropy analysis of these three indices. A questionnaire survey was developed based on the purpose of the study and the conclusion of the content analysis, which conducted to analyze users' requirements for health knowledge and their influencing factors. Moreover, risk factors were explored by logistic regression models.Results: Of the 103 articles considered in this study, four articles in the Top 10 were related to nutrition and diet. The influence index of nutrition and diet knowledge was found to be the highest in the content analysis (p &lt; 0.05). The higher degrees of humor (β = 0.224, p = 0.027), nutrition and diet articles (β = 0.776, p = 0.034), and cover articles (β = 0.312, p = 0.021) have significant influences on the influence index. In total, 581 questionnaires were obtained, and 78.1% of the respondents reported believing that the health knowledge of greatest concern was that related to nutrition and diet. Multivariate logistic regression analyses were conducted to explore the associations between the features of the articles and users reading nutrition and diet knowledge; it was found that gender (female, OR: 4.651, 95%Cl: 2.598, 8.325, and p &lt; 0.001), age (young adult, OR: 0.358, 95%Cl: 0.266, 0.481, and p &lt; 0.001), cancer precaution knowledge (OR: 4.333, 95%Cl: 2.262, 8.299, and p &lt; 0.001), traditional Chinese medicine (OR: 2.121, 95%Cl: 1.064, 4.230, and p = 0.033), the knowledge acquisition approach [circle of friends (OR: 2.586, 95%Cl: 1.373, 4.868, and p = 0.003), social media (OR: 2.183, 95%Cl: 1.204, 3.960, and p = 0.010)), hospitals (OR: 3.194, 95%Cl: 1.793, 5.692, and p &lt; 0.001), television media (OR: 4.348, 95%Cl: 2.341, 8.077, and p &lt; 0.001)], and social media strategies [professionalism and authority (OR: 2.354, 95%Cl: 1.231, 4.505, and p = 0.006)] have statistically significant relationships with users reading nutrition and diet knowledge.Conclusion: Nutrition and diet knowledge could contribute to WeChat user engagement of health information dissemination. Nutrition professionals should improve the scientific popularization ability and effectively use social media for health promotion.
Assessing the Role of Collective Efficacy Beliefs During Participative Occupational Health Interventions
Authors: Kuchenbaur Marco , Peter Richard 
Published: November 2021

Background: For group-based participatory interventions in the context of occupational health, no questionnaires exist to assess the participants' active engagement in the interventions. On the basis of the construct of collective efficacy beliefs, this study has developed a questionnaire with which the group-related efficacy beliefs can be assessed as a precondition for participants actively engaging in participative interventions.Methods: Participants were drawn from a two-arm cluster-randomized intervention study to fill out the questionnaire. A Factor analysis and an initial psychometric calibration were performed. In a second step, the group-related properties of the questionnaire were validated using a Multilevel analysis.Results: The factorial structure of the questionnaire is consistent with the theory of efficacy beliefs according to A. Bandura. Furthermore, the collective efficacy expectations of the interventions' participants are lowered in the absence of appreciation and support in the psychosocial environment of the worksite.Conclusions: Assessing participant's quality of interventional activity in participatory interventions by collective efficacy can be valuable in understanding the amount of interventional activity. In addition, it is recommended to consider the influence of the worksite's psychosocial environment on collective efficacy beliefs when implementing participatory interventions.Clinical Trial Registration: Registration trial DRKS00021138 on the German Registry of Clinical Studies (DRKS), retrospectively registered on 25 March, 2020.
Treatment Outcomes and the Safety of Chemoradiotherapy With High-Dose CDDP for Elderly Patients With Head and Neck Squamous Cell Carcinoma: A Propensity Score Matching Study
Authors: Omata Jo , Ueki Yushi , Takahashi Takeshi , Shodo Ryusuke , Yamazaki Keisuke , Saijo Kohei , Ota Hisayuki , Togashi Takafumi , Sato Yuichiro , Horii Arata 
Published: November 2021

Objective: We aimed to compare the outcomes and safety of chemoradiotherapy (CRT) between elderly and non-elderly patients with head and neck squamous cell carcinoma (HNSCC). It is difficult to assess the causal effect of age because of possible differences in general conditions among individuals. Therefore, we adjusted the background factors of elderly and non-elderly patients using propensity score matching (PSM).Methods: A total of 146 patients with HNSCC who received CRT were divided into an elderly (≥70 years, n = 35) and non-elderly group (&lt;70 years, n = 111). Pre-treatment characteristics, including the performance status, Charlson comorbidity index, body mass index, primary site, and TNM stage were adjusted by PSM. We compared the outcomes and safety of CRT with high-dose single-agent cisplatin (CDDP) as well as outcomes following recurrence between the groups, before and after PSM.Results: The total dose of CDDP administered during CRT was significantly lower in the elderly group before PSM. However, it became comparable to the non-elderly group and adverse events did not differ between the groups following PSM, resulting in a comparable CRT completion rate. Overall-, disease specific-, and progression-free survivals of elderly patients were comparable to those of non-elderly patients following PSM. In contrast, elderly patients with recurrence could receive fewer salvage treatments than their non-elderly counterparts, resulting in worse survival.Conclusions: CRT with high-dose CDDP is safe and effective for the treatment of elderly patients with HNSCC. However, salvage treatments can be rarely conducted for elderly patients with a recurrence, considering a deterioration of their general condition.
Multivariate Analysis and Validation of the Prognostic Factors for Skull Base Chordoma
Authors: Teng Chubei , Yang Qi , Xiong Zujian , Ye Ningrong , Li Xuejun 
Published: November 2021

Background: Skull base chordoma is a rare tumor with low-grade malignancy and a high recurrence rate, the factors affecting the prognosis of patients need to be further studied. For that, we investigated prognostic factors of skull base chordoma through the database of the Surveillance, Epidemiology, and End Results (SEER) program, and validated in an independent data set from the Xiangya Hospital.Methods: Six hundred and forty-three patients diagnosed with skull base chordoma were obtained from the SEER database (606 patients) and the Xiangya Hospital (37 patients). Categorical variables were selected by Chi-square test with a statistical difference. Survival curves were constructed by Kaplan–Meier analysis and compared by log-rank test. Univariate and multivariate Cox regression analyses were used to explore the prognostic factors. Propensity score matching (PSM) analysis was undertaken to reduce the substantial bias between gross total resection (GTR) and subtotal resection (STR) groups. Furthermore, clinical data of 37 patients from the Xiangya Hospital were used as validation cohorts to check the survival impacts of the extent of resection and adjuvant radiotherapy on prognosis.Results: We found that age at diagnosis, primary site, disease stage, surgical treatment, and tumor size was significantly associated with the prognosis of skull base chordoma. PSM analysis revealed that there was no significant difference in the OS between GTR and STR (p = 0.157). Independent data set from the Xiangya Hospital proved no statistical difference in OS between GTR and STR groups (p = 0.16), but the GTR group was superior to the STR group for progression-free survival (PFS) (p = 0.048). Postoperative radiotherapy does not improve OS (p = 0.28), but it can prolong PFS (p = 0.0037). Nomograms predicting 5- and 10-year OS and DSS were constructed based on statistically significant factors identified by multivariate Cox analysis. Age, primary site, tumor size, surgical treatment, and disease stage were included as prognostic predictors in the nomograms with good performance.Conclusions: We identified age, tumor size, surgery, primary site, and tumor stage as main factors affecting the prognosis of the skull base chordoma. Resection of the tumor as much as possible while ensuring safety, combined with postoperative radiotherapy may be the optimum treatment for skull base chordoma.
Intravesical Chemohyperthermia vs. Bacillus Calmette-Guerin Instillation for Intermediate- and High-Risk Non-muscle Invasive Bladder Cancer: A Systematic Review and Meta-Analysis
Authors: Zhao Hongda , Chan Vinson Wai-Shun , Castellani Daniele , Chan Erica On-Ting , Ong William Lay Keat , Peng Qiang , Moschini Marco , Krajewski Wojciech , Pradere Benjamin , Ng Chi-Fai , Enikeev Dmitry , Vasdev Nikhil , Ekin Gokhan , Sousa Alejandro , Leon Juan , Guerrero-Ramos Felix , Tan Wei-Shen , Kelly John , Shariat Shahrokh F. , Witjes J. Alfred , Teoh Jeremy Yuen-Chun 
Published: November 2021

Background: The efficacy of intravesical chemotherapy maintenance for patients with non-muscle invasive bladder cancer (NMIBC) is inferior compared to intravesical bacillus Calmette–Guerin (BCG). How intravesical chemohyperthermia (CHT) compares with BCG is under investigation.Objective: To compare the oncological outcomes and safety profile between intravesical CHT and BCG treatment for intermediate- and high-risk NMIBC.Methods: We performed a systematic review and meta-analysis of clinical studies comparing CHT with BCG for intermediate- and high-risk NMIBC patients. A comprehensive literature search on OVID MEDLINE, EMBASE, and Cochrane Library was conducted. Risk of bias was assessed by the Cochrane RoB tool and ROBINS-I. Certainty of evidence was rated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology.Results: A total of 2,375 articles were identified and five studies were finally included. Among them, four randomised trials comprising 327 patients (CHT group: 156 patients; BCG group: 171 patients) were included in the meta-analysis. There were no significant differences in the 24–36 months recurrence rates (CHT: 29.5%, BCG: 37.4%; RR: 0.83, 95% CI 0.61–1.13; moderate certainty of evidence) and the 24–36 months progression rates (CHT: 4.4%, BCG: 7.6%, RR = 0.62, 95% CI 0.26–1.49; low certainty of evidence). There were also no significant differences in grade 1–2 adverse events (CHT group: 59.9%, BCG group 54.5%; RR = 1.10, 95% CI 0.93–1.30; moderate certainty of evidence) and grade 3 or above adverse events (CHT group: 23.2%, BCG group 22.5%; RR = 0.99, 95% CI 0.69–1.43; low certainty of evidence).Conclusions: Intravesical CHT had equivalent oncological outcomes and similar safety profile when compared to BCG maintenance therapy for patients with intermediate- and high-risk NMIBC. CHT is a possible alternative treatment in the times of BCG shortage.
Xerotolerance: A New Property in Exiguobacterium Genus
Authors: López María Castillo , Galán Beatriz , Carmona Manuel , Navarro Llorens Juana María , Peretó Juli , Porcar Manuel , Getino Luis , Olivera Elías R. , Luengo José M. , Castro Laura , García José Luís 
Published: November 2021

The highly xerotolerant bacterium classified as Exiguobacterium sp. Helios isolated from a solar panel in Spain showed a close relationship to Exiguobacterium sibiricum 255-15 isolated from Siberian permafrost. Xerotolerance has not been previously described as a characteristic of the extremely diverse Exiguobacterium genus, but both strains Helios and 255-15 showed higher xerotolerance than that described in the reference xerotolerant model strain Deinococcus radiodurans. Significant changes observed in the cell morphology after their desiccation suggests that the structure of cellular surface plays an important role in xerotolerance. Apart from its remarkable resistance to desiccation, Exiguobacterium sp. Helios strain shows several polyextremophilic characteristics that make it a promising chassis for biotechnological applications. Exiguobacterium sp. Helios cells produce nanoparticles of selenium in the presence of selenite linked to its resistance mechanism. Using the Lactobacillus plasmid pRCR12 that harbors a cherry marker, we have developed a transformation protocol for Exiguobacterium sp. Helios strain, being the first time that a bacterium of Exiguobacterium genus has been genetically modified. The comparison of Exiguobacterium sp. Helios and E. sibiricum 255-15 genomes revealed several interesting similarities and differences. Both strains contain a complete set of competence-related DNA transformation genes, suggesting that they might have natural competence, and an incomplete set of genes involved in sporulation; moreover, these strains not produce spores, suggesting that these genes might be involved in xerotolerance.
SISTEM PENILAIAN SELEKSI CALON KARYAWAN BARU MENGGUNAKAN METODE SIMPLE ADDITIVE WEIGHTING (SAW) DI PT.TNA
Authors: Wahyuningsih Anik Sri , Firmansyah Yudhi 
Published: November 2021

Dalam hal penerimaan karyawan baru atau rekrutmen adalah suatu keharusan dan hal yang penting bagi perusahaan untuk memperoleh calon karyawan baru dalam menduduki suatu jabatan dalam suatu pekerjaan. Banyak perusahaan dalam proses penerimaan karyawan baru masih belum dilakukan secara profesional. Hal ini terjadi karena tidak ada metode standar yang sistematis untuk menilai kelayakan calon karyawan baru. Biasanya dalam pengambilan keputusan penerimaan karyawan baru dilakukan secara manual dengan melihat semua data-data calon karyawan dan ini membutuhkan waktu yang lama. Dengan melihat fenomena tersebut peran divisi Sumber Daya Manusia (SDM) dalam menangani permasalahan penerimaan karyawan baru tentunya masih belum maksimal. Peran divisi Sumber Daya Manusia (SDM) dalam hal ini staff hingga manajer yang melakukan seleksi sangat dibutuhkan sejak awal proses penerimaan karyawan baru. Untuk memecahkan permasalahan tersebut perlu dibuatkan suatu sistem pendukung keputusan yang dapat membantu perusahaan terutama manajer divisi Sumber Daya Manusia (SDM) dalam pengambilan keputusan untuk menentukan karyawan baru di suatu perusahaan. Salah satu aplikasi sistem pendukung keputusan penerimaan karyawan baru yaitu menggunakan metode Simple Additive Weighting (SAW). Salah satu metode ini dipilih karena dapat menentukan nilai bobot untuk setiap atribut, kemudian dilanjutkan dengan proses perankingan yang akan menyeleksi alternatif terbaik dari sejumlah alternatif, dalam hal ini alternatif yang dimaksud adalah yang berhak dan layak diterima sebagai karyawan baru berdasarkan kriteria-kriteria yang telah ditentukan sebelumnya. Berdasarkan dari hasil pengujian, sistem yang dibuat dan diterapkan dapat mempermudah dan mempercepat proses penyeleksian penerimaan karyawan baru sehingga membantu manajer pada divisi Sumber Daya Manusia (SDM) dalam pengambilan keputusan untuk menentukan karyawan baru di suatu perusahaan.
Intensità nello spazio urbano
Authors: Celestini Gianni 
Published: November 2021

Mutamenti investono l’habitat contemporaneo, determinando una rivoluzione di comportamenti con impatti mai visti per rapidità ed intensità sulla ridefinizione di forme e funzioni dello spazio. Espressioni come ‘luogo d’incontro’ e ‘scambio sociale’ seppur generiche e prive di carattere esprimono l’esigenza di ritrovare legami tra le persone messi a dura prova da una serie di processi, alcuni di lunga durata, che sembrano minare alla radice lo spirito comunitario insito nel concetto di urbanità. In un mondo sempre più denso di esseri, cose, informazioni e immagini i territori sono modellati dalle increspature e da collisioni inedite che provocano la scomparsa degli spazi comuni della città.
Nella pratica dei paesaggisti è ormai consolidata la consapevolezza che gli spazi aperti esprimono un potenziale strutturante e relazionale per l’habitat urbano; possono diventare il luogo di accadimenti possibili e la loro natura accogliente rappresenta una formidabile energia propulsiva con la quale rivelare l’intensità. È su questo terreno che il progetto può giocare un ruolo, non certo pacificatore né ordinatore, ma riconoscendo e attivando il potenziale della situazione, lavorando con ciò che c’è anche se si tratta di caratteri contraddittori, incerti, instabili.