bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synchronous occurrence of breast fibroadenoma with osseous metaplasia and invasive lobular carcinoma; a case report with literature review
Authors: Salh Abdulwahid M. , Abdullah Ari M. , Kakamad Fahmi H. , Hammood Zuhair D. , Mikael Tomas M. , Hassan Shko H. 
Published: December 2021

ABSTRACT

Introduction and importance:
Osseous metaplasia is an extremely rare finding in the breasts, especially in association with benign tumors. This paper aims to present the first case of synchronous breast fibroadenoma with osseous metaplasia and invasive lobular carcinoma (ILC).

Case presentation:
A 45-year-old female presented with right breast lump for a year. She was hypertensive and had been pregnant for 9 times, in which 5 of them were aborted. Upon examination, there was a painful large mass in right breast. Ultrasound (US) showed multiple masses in the right breast, with the largest one measuring 32 × 16 mm and containing macrocalcification. US also revealed two benign masses in the left breast. Mammography showed an ill-defined asymmetrical density toward the nipple in right breast with two large macrocalcifications. Wide local excision was performed for the right breast, and histopathology examination revealed fibroadenoma with osseous metaplasia, and ILC.

Clinical discussion:
Although osseous metaplasia is rare, it has been observed in various parts of the body that contain soft tissues. To date, only a few cases have been reported in the breast with all of them being associated with malignant neoplasms. It is believed that these heterotrophic bony tissues develop when stromal fibroblasts are transformed by metaplasia into osteoblasts.

Conclusion:
Despite its rarity, benign osseous metaplasia can still occur in the breasts, most commonly in middle-aged females with a painful lump being the first presentation.

Highlights
Curation of the John and Phil Palmquist Archaeological Collection
Authors: Doershuk John F. , Davis Warren D. , Palmquist John 
Published: December 2021

AbstractThe 2018 SAA statement encouraging collaboration between archaeologists and “responsible and responsive stewards” included recommendations epitomizing decades of established practice at the University of Iowa Office of the State Archaeologist (OSA), a research center housing the State Archaeological Repository of Iowa. At the time the SAA statement was published, OSA staff were actively implementing a grant supporting transfer to the State Repository of the John and Phil Palmquist Archaeological Collection. This grant was designed to provide hands-on research experience for undergraduate students interested in archaeology and collections management while recording improved site locational data and artifact specific documentation, including on relatively rare (for the area) red pipestone artifacts. Although modest by some standards, the Palmquist Collection includes 860 artifacts from 26 locations recorded through 40 years of surface survey by the family in a portion of Iowa that is rarely the focus of professional archaeologists. This article provides a case study of responsible archaeological practice implementing SAA recommendations, including treating collector-collaborators with respect, encouraging collector assistance in the recording of finds, capturing research data from a private collection, and facilitating curation of privately owned materials. We include brief consideration of the impact of the Palmquist Collection on the understanding of southwestern Iowa archaeology.
Market Definition in the Platform Economy
Authors: FRANCK Jens-Uwe , PEITZ Martin 
Published: December 2021

AbstractThe article addresses the role market definition can play for EU competition practice in the platform economy. The focus is on intermediaries that bring together groups of users whose decisions are interdependent, which therefore are commonly referred to as ‘two-sided platforms’. We address challenges to market definition that accompany these cross-group network effects, assess current practice in a number of competition cases, and provide guidance for adapting practice to properly account for the economic forces shaping markets with two-sided platforms. We ask whether and when a single market can be defined that encompasses both sides. We advocate a multi-markets approach that takes account of cross-market linkages, acknowledges the existence of zero-price markets, and properly accounts for the homing behaviour of market participants.
Preliminary evidence on combined cognitive behavioral therapy and motivational interviewing intervention efficacy to improve employment motivation for persons with intellectual disability
Authors: Diallo Abdoulaye , Fonseca Lidia , Holland Diana 
Published: December 2021

AbstractThis study investigated the efficacy of a combined modified cognitive behavioral therapy (CBT) and motivational interviewing (MI) approach on motivating persons with intellectual disabilities (ID) in obtaining employment. The sample consisted of a total of 52 individuals with ID who were clients of an independent vocational-rehabilitation services provider (females = 42%; males = 58%), ranging in age from 19 to 47. They were randomly assigned to an intervention group (n = 26) and a control group (n = 26). The intervention group received a combined modified CBT and MI intervention and the control group a fact sheet on career-dysfunctional thoughts and lack of motivation to obtain employment. Outcome measures comprised a career-dysfunctional thoughts scale and employment seeking action scale. Results indicated that the intervention group reported higher motivation in obtaining employment than the control. Practitioners seeking to improve employment prospects for persons with ID should consider the use of a combined modified CBT and MI intervention for increasing the chances of employment seeking by people with ID.
Determinants of Bicameral Conflict: The Formation of Conference Committees in Chile, 1990-2018
Authors: Navia Patricio , Mimica Nicolás 
Published: December 2021

ABSTRACTIn some countries, bicameral discrepancies are solved by the formation of a conference committee. In Chile, conference committees are exclusively and automatically formed when the second chamber rejects a bill passed in the first chamber or when the first chamber rejects the modifications to its original bill made by the second chamber. This article postulates 4 hypotheses for the determinants of conference committee formation. It tests them for the case of Chile’s sequential legislative process (1990–2018) using 2,183 bills that reached the stage where a conference committee could be formed. The 482 conference committees that resulted were more likely to be formed when chambers were controlled by different majorities, when passage required special voting thresholds, when bills were more important for the president, and when the bills had more approved amendments, but they were not more likely if the bill was introduced by legislators rather than the executive.
Exploring facilitators and barriers to introducing health technology assessment: a systematic review
Authors: Suharlim Christian , Kumar Ritu , Salim Julian , Mehra Meenakshi , Gilmartin Colin , Amaris Caruso Ana , Castro Hector 
Published: December 2021

Abstract

Objective
This study aims to identify and codify the facilitators and barriers to help implementing partners institutionalize health technology assessment (HTA) successfully and navigate complex systems for health-related policy making.

Methods
We searched for peer-reviewed and gray literature articles examining HTA programs globally using six databases. Keywords used as a guide for capturing articles included “health technology assessment,” “barrier,” and “facilitator” and their synonyms. Search results were scrutinized for duplicates and screened through a review of titles and abstracts. A full-text review was conducted exploring articles’ coverage of twenty-seven evaluation criteria across four primary areas of interest: barriers/facilitators, motivations, guidelines, and institutional frameworks.

Results
A total of 18,599 records were identified for duplication check, title, and abstract review. A total of 1,594 articles underwent full-text review, leading to a final synthesis of 262 studies. We found that ninety-seven articles discussed barriers/facilitators, with fifty-three of those discussing local capacity and unavailable human resources. Out of the sixty-six articles discussing motivations, forty-two cited the interest in supporting the decision-making process for, and promoting, appropriate resource allocation. Of the sixty-one articles that discussed guidelines and institutional framework, twenty-one articles described HTA as an independent national unit, and sixteen described their HTA unit as a unit within the Ministry of Health (MOH).

Conclusions
This systematic review unpacks the dynamic and relevant contexts for understanding the HTA institutionalization process to help policy makers and practitioners achieve tangible progress in confronting the most critical issues facing priority setting and HTA institutionalization.
Wealth and Consumption After Job Displacement
Authors: Barnette Justin 
Published: December 2021

AbstractIncome drops permanently after an involuntary job displacement, but it has never been clear what happens to long run wealth in the USA. Upon displacement, wealth falls 14% relative to workers of the same age and similar education from the Panel Study of Income Dynamics (PSID). Their wealth is still 18% lower 12 years after the event. A standard life cycle model calibrated to US data with permanent decreases in income after displacement behaves differently than these findings. The agents in the model also experience a large drop in wealth but they recover. The biggest culprit for these differences is small and statistically insignificant changes to consumption in the PSID whereas agents in the model decrease their consumption considerably. Extending the model to include habit formation reconciles some of these differences by generating similar long run effects on wealth. This allows for the examination of wealth at death through the lens of the model.
‘The Timpani Beats Just Hit on My Heart!’ Music, Memory, and Diplomacy in the Philadelphia Orchestra's 1973 China Tour
Authors: LIU BESS XINTONG 
Published: December 2021

AbstractThis article examines the underexplored history of the 1973 Philadelphia Orchestra China tour and retheorizes twentieth-century musical diplomacy as a process of ritualization. As a case study, I consult bilingual archives and incorporate interviews with participants in this event, which brings together individual narratives and public opinions. By contextualizing this musical diplomacy in the Cold War détente and the Chinese Cultural Revolution, I argue for the complex set of relations mobilized by Western art music in 1973. This tour first created a sense of co-dependency between musicians and politicians. It also engaged Chinese audiences by revitalizing pre-Cultural Revolution sonic memories. Second, I argue that the significance of the 1973 Orchestra tour lies in the ritualization of Western art music as diplomatic etiquette, based on further contextualization of this event in the historical trajectory of Sino-US relations and within the entrenched Chinese ideology ofliyue(ritual and music).
Red blood cell distribution width as a predictor of mortality among patients regularly visiting the nephrology outpatient clinic
Authors: Yoo Kyung Don , Oh Hyung Jung , Park Sehoon , Kang Min Woo , Kim Yong Chul , Park Jae Yoon , Lee Jeonghwan , Lee Jong Soo , Kim Dong Ki , Lim Chun Soo , Kim Yon Su , Lee Jung Pyo ,   Korean Association for the study of Renal Anemia and artificial Intelligence (KARAI), Kim Dong Ki , Lim Chun Soo , Lee Jung Pyo 
Published: December 2021

AbstractThe association between increased red blood cell distribution width (RDW) and mortality among patients treated on an outpatient basis in the nephrology outpatient clinic is unclear. Therefore, our study aimed to investigate the association between baseline and time-averaged RDW and mortality risk in patients treated in our nephrology outpatient clinic. Our multi-center retrospective analysis was based on data of 16,417 outpatient nephrology patients with available baseline renal function and RWD values. The median baseline RDW was 13.0% (range, 10.0–32.1%). The high-RDW group was defined as the top quartile (≥ 13.8%, n = 4302). The crude mortality rate was 15.0% (n = 1806) at a median follow-up of 127.5 months. From the results of the multivariate Cox proportional hazards regression model adjusted for covariates, including eGFR, hemoglobin, and factors of anemia treatment, patients with a high time-averaged RDW had increased mortality risk (adjusted hazard ratio, 1.505; 95% confidence interval, 1.326–1.708; P < 0.001), irrespective of sex, presence of anemia, and chronic kidney disease, except in individuals aged < 45 years. Thus, increased baseline and time-averaged RDW were significantly associated with increased mortality in patients aged > 45 years treated on an outpatient basis in the nephrology clinic.
Population structure and adaptive variation of Helichrysum italicum (Roth) G. Don along eastern Adriatic temperature and precipitation gradient
Authors: Ninčević Tonka , Jug-Dujaković Marija , Grdiša Martina , Liber Zlatko , Varga Filip , Pljevljakušić Dejan , Šatović Zlatko 
Published: December 2021

AbstractImmortelle (Helichrysum italicum(Roth) G. Don; Asteraceae) is a perennial plant species native to the Mediterranean region, known for many properties with wide application mainly in perfume and cosmetic industry. A total of 18 wildH. italicumpopulations systematically sampled along the eastern Adriatic environmental gradient were studied using AFLP markers to determine genetic diversity and structure and to identify loci potentially responsible for adaptive divergence. Results showed higher levels of intrapopulation diversity than interpopulation diversity. Genetic differentiation among populations was significant but low, indicating extensive gene flow between populations. Bayesian analysis of population structure revealed the existence of two genetic clusters. Combining the results ofFST - outlier analysis (Mcheza and BayeScan) and genome-environment association analysis (Samβada, LFMM) four AFLP loci strongly associated with the bioclimatic variables Bio03 Isothermality, Bio08 Mean temperature of the wettest quarter, Bio15 Precipitation seasonality, and Bio17 Precipitation of driest quarter were found to be the main variables driving potential adaptive genetic variation inH. italicumalong the eastern Adriatic environmental gradient. Redundancy analysis revealed that the partitioning of genetic variation was mainly associated with the adaptation to temperature oscillations. The results of the research may contribute to a clearer understanding of the importance of local adaptations for the genetic differentiation of Mediterranean plants and allow the planning of appropriate conservation strategies. However, considering that the identified outlier loci may be linked to genes under selection rather than being the target of natural selection, future studies must aim at their additional analysis.
Neurokinin receptor mechanisms in forebrain medial septum modulate nociception in the formalin model of inflammatory pain
Authors: Ng Si Yun , Ariffin Mohammed Zacky , Khanna Sanjay 
Published: December 2021

AbstractThe present study has explored the hypothesis that neurokinin1 receptors (NK1Rs) in medial septum (MS) modulate nociception evoked on hind paw injection of formalin. Indeed, the NK1Rs in MS are localized on cholinergic neurons which have been implicated in nociception. In anaesthetized rat, microinjection of L-733,060, an antagonist at NK1Rs, into MS antagonized the suppression of CA1 population spike (PS) evoked on peripheral injection of formalin or on intraseptal microinjection of substance P (SP), an agonist at NK1Rs. The CA1 PS reflects the synaptic excitability of pyramidal cells in the region. Furthermore, microinjection of L-733,060 into MS, but not LS, attenuated formalin-induced theta activation in both anaesthetized and awake rat, where theta reflects an oscillatory information processing by hippocampal neurons. The effects of L-733,060 on microinjection into MS were nociceptive selective as the antagonist did not block septo-hippocampal response to direct MS stimulation by the cholinergic receptor agonist, carbachol, in anaesthetized animal or on exploration in awake animal. Interestingly, microinjection of L-733,060 into both MS and LS attenuated formalin-induced nociceptive flinches. Collectively, the foregoing novel findings highlight that transmission at NK1R provide an affective valence to septo-hippocampal information processing and that peptidergic transmission in the septum modulates nociceptive behaviours.
Antimicrobial efficacy of Egyptian Eremina desertorum and Helix aspersa snail mucus with a novel approach to their anti-inflammatory and wound healing potencies
Authors: EL-Zawawy Nessma A. , Mona Mahy M. 
Published: December 2021

AbstractSnail mucus is composed of bioactive compounds thought to have different biological properties for the treatment of some skin problems. Although Helix aspersa mucus is used in several cosmetic products, a detailed characterization of Eremina desertorum mucus composition and its biological activities is still missing. Mucus extracts (MEs) from H. aspersa and E. desertorum were prepared and tested for their antimicrobial and anti-inflammatory activities with their potencies in wound healing. Also, chemical characterization was performed by GC–MS analysis. Results showed that ME of E. desertorum gave higher inhibitory activity against resistant strains related to burn wound infections compared to ME of H. aspersa. Additionally, it revealed a significant anti-inflammatory activity. Moreover, we found that ME of E. desertorum lacked cytotoxicity and was able to significantly induce cell proliferation and migration through up-regulation of TGF-β1 and VEGF gene expression. Our results suggested that MEs of E. desertorum have higher biological effects than H. aspersa, which are attributable to antimicrobial, anti-inflammatory activities, cell proliferation and pave the way for further investigating its potential effect as a human therapeutic agent.
Machine learning-assisted ammonium detection using zinc oxide/multi-walled carbon nanotube composite based impedance sensors
Authors: Aliyana Akshaya Kumar , Naveen Kumar S. K. , Marimuthu Pradeep , Baburaj Aiswarya , Adetunji Michael , Frederick Terrance , Sekhar Praveen , Fernandez Renny Edwin 
Published: December 2021

AbstractWe report a machine learning approach to accurately correlate the impedance variations in zinc oxide/multi walled carbon nanotube nanocomposite (F-MWCNT/ZnO-NFs) to NH4+ ions concentrations. Impedance response of F-MWCNT/ZnO-NFs nanocomposites with varying ZnO:MWCNT compositions were evaluated for its sensitivity and selectivity to NH4+ ions in the presence of structurally similar analytes. A decision-making model was built, trained and tested using important features of the impedance response of F-MWCNT/ZnO-NF to varying NH4+ concentrations. Different algorithms such as kNN, random forest, neural network, Naïve Bayes and logistic regression are compared and discussed. ML analysis have led to identify the most prominent features of an impedance spectrum that can be used as the ML predictors to estimate the real concentration of NH4+ ion levels. The proposed NH4+ sensor along with the decision-making model can identify and operate at specific operating frequencies to continuously collect the most relevant information from a system.
Cx43 carboxyl terminal domain determines AQP4 and Cx30 endfoot organization and blood brain barrier permeability
Authors: Cibelli Antonio , Stout Randy , Timmermann Aline , de Menezes Laura , Guo Peng , Maass Karen , Seifert Gerald , Steinhäuser Christian , Spray David C. , Scemes Eliana 
Published: December 2021

AbstractThe neurovascular unit (NVU) consists of cells intrinsic to the vessel wall, the endothelial cells and pericytes, and astrocyte endfeet that surround the vessel but are separated from it by basement membrane. Endothelial cells are primarily responsible for creating and maintaining blood–brain-barrier (BBB) tightness, but astrocytes contribute to the barrier through paracrine signaling to the endothelial cells and by forming the glia limitans. Gap junctions (GJs) between astrocyte endfeet are composed of connexin 43 (Cx43) and Cx30, which form plaques between cells. GJ plaques formed of Cx43 do not diffuse laterally in the plasma membrane and thus potentially provide stable organizational features to the endfoot domain, whereas GJ plaques formed of other connexins and of Cx43 lacking a large portion of its cytoplasmic carboxyl terminus are quite mobile. In order to examine the organizational features that immobile GJs impose on the endfoot, we have used super-resolution confocal microscopy to map number and sizes of GJ plaques and aquaporin (AQP)-4 channel clusters in the perivascular endfeet of mice in which astrocyte GJs (Cx30, Cx43) were deleted or the carboxyl terminus of Cx43 was truncated. To determine if BBB integrity was compromised in these transgenic mice, we conducted perfusion studies under elevated hydrostatic pressure using horseradish peroxide as a molecular probe enabling detection of micro-hemorrhages in brain sections. These studies revealed that microhemorrhages were more numerous in mice lacking Cx43 or its carboxyl terminus. In perivascular domains of cerebral vessels, we found that density of Cx43 GJs was higher in the truncation mutant, while GJ size was smaller. Density of perivascular particles formed by AQP4 and its extended isoform AQP4ex was inversely related to the presence of full length Cx43, whereas the ratio of sizes of the particles of the AQP4ex isoform to total AQP4 was directly related to the presence of full length Cx43. Confocal analysis showed that Cx43 and Cx30 were substantially colocalized in astrocyte domains near vasculature of truncation mutant mice. These results showing altered distribution of some astrocyte nexus components (AQP4 and Cx30) in Cx43 null mice and in a truncation mutant, together with leakier cerebral vasculature, support the hypothesis that localization and mobility of gap junction proteins and their binding partners influences organization of astrocyte endfeet which in turn impacts BBB integrity of the NVU.