bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electronic Nature of Charge Density Wave and Electron-Phonon Coupling in Kagome Superconductor KV3Sb5
Authors: Zhou Xingjiang , Luo Hai-Lan , Gao Qiang , Liu Hongxiong , Gu Yuhao , Wu Ding-Song , Yi Changjiang , Jia Junjie , Wu Shilong , Luo Xiangyu , Xu Yu , Zhao Lin , Wang Qing-Yan , Mao Hanqing , Liu Guodong , Zhu Zhihai , Shi Youguo , Jiang Kun , Hu Jiangping , Xu Zuyan 
Published: August 2021

Abstract
The Kagome superconductors AV3Sb5 (A=K, Rb, Cs) have received enormous attention due to their nontrivial topological electronic structure, anomalous physical properties and superconductivity. Unconventional charge density wave (CDW) has been detected in AV3Sb5 that is found to be intimately intertwined with the anomalous Hall effect and superconductivity. High-precision electronic structure determination is essential to understand the origin of the CDW transition and its interplay with electron correlation, topology and superconductivity, yet, little evidence has been found about the impact of the CDW state on the electronic structure in AV3Sb5. Here we unveil electronic nature of the CDW phase in our high-resolution angle-resolved photoemission (ARPES) measurements on KV3Sb5. We have observed CDW-induced Fermi surface reconstruction and the associated band structure folding. The CDW-induced band splitting and the associated gap opening have been revealed at the boundary of the pristine and reconstructed Brillouin zone. The Fermi surface- and momentum-dependent CDW gap is measured for the first time and the strongly anisotropic CDW gap is observed for all the V-derived Fermi surface sheets. In particular, we have observed signatures of the electron-phonon coupling for all the V-derived bands. These results provide key insights in understanding the nature of the CDW state and its interplay with superconductivity in AV3Sb5 superconductors.
Optimal Geometric Characterization of Forced Zonal Mean Tropical Precipitation Changes.
Authors: Donohoe Aaron , Atwood Alyssa R , Battisti David S 
Published: August 2021

Abstract
The zonal and annual mean tropical precipitation response to paleoclimate and anthropogenic forcing scenarios ranging from the Last Glacial Maximum (LGM), CO2 quadrupling (4XCO2 ), mid-Holocene, North Atlantic freshwater hosing and volcanic forcing is analyzed in an ensemble of global climate models. Zonally averaged tropical precipitation changes are characterized in terms of three geometric manipulations of the climatological precipitation (hereafter, modes): meridional shifts, intensifications, and meridional contractions. We employ an optimization procedure that quantifies the magnitude and robustness (across different models) of changes in each mode in response to each forcing type. Additionally, the fraction of precipitation changes that are explained by the modes (in isolation and combined) is quantified. Shifts are generally less than 1º latitude in magnitude and explain a small fraction (<10%) of tropical precipitation changes. Contractions and intensifications are strongly anti-correlated across all simulations with a robust intensification and contraction of precipitation under global warming and a robust reduction and expansion under global cooling during the Last Glacial Maximum. The near constant scaling between contractions and intensifications across all simulations is used to define a joint contraction/intensification (CI) mode of tropical precipitation. The CI mode explains nearly 50% of the precipitation change under 4XCO2 and LGM forcing by optimizing a single parameter. These results suggest the shifting mode that has been extensively used to interpret paleo-rainfall reconstructions is of limited use for characterizing forced zonal mean precipitation changes and advocates for a reinterpretation of past precipitation changes to account for the CI mode
A Preliminary Attempt On Decadal Prediction of The East Asian Summer Monsoon
Authors: Qian Danwei , Huang Yanyan , Wang Huijun 
Published: August 2021

Abstract
The East Asian summer monsoon (EASM) is one of the major synoptic systems that affect the summer climate in China. The anomaly of the EASM is closely related to the occurrence of droughts and floods in China. Decadal prediction of the EASM is of great significance, yet few attempts have been made by far. This study represents a preliminary attempt that uses the decadal increment (DI) method to predict the decadal variability of the EASM. The 3-year increment of the decadal variability is used as the predictand, and predictors are selected from the previous circulation and external forcing. The predicted increment is combined with the observation three years ago to get the final prediction result. The results of cross validation and independent hindcast show that the decadal increment method can well predict decadal variability of the EASM during the recent century. In particular, the decadal regime shifts of the EASM are accurately captured. The decadal variability of the EASM in 2021 is further predicted with two previous predictors of the leading 4-year summer DI of the South Indian Ocean and the DI of the East Siberian Sea sea ice cover. The real-time prediction results show that the chance for the occurrence of strong decadal EASM would be rare in 2021 and 2022. The method developed in the present study provides a new approach for decadal prediction of the EASM.
Effect of Concentration of Mo on The Mechanical Behavior of UMo Fuel: An Atomistic Study
Authors: Ullah Asmat , Ado Muhammad , Adede Simon 
Published: August 2021

Abstract
We performed molecular dynamics simulation on nanoindentation of Uranium Molybdenum alloys using spherical indenter. A ternary potential developed for UMoXe was utilized. We calculated the updated values for hardness and reduced elastic modulus at different concentrations of Mo. The whole process of deformation and dislocation analysis was visualized using OVITO. We found an increase in deformation with increase in stress while dislocations are not found anyhow induced defects have been distributed throughout the simulation cell randomly. The increase in concentration affected the hardness and reduced elastic modulus significantly.
FOXM1 Drives Epithelial-Mesenchymal Transition Program Through E-Cadherin Promoter Biding Ability in Non-Small-Cell Lung Cancer Cells
Authors: Wang Ling , Xiaolan Lin , Jiang ZongSheng , Sun Yanzi , Li Yixuan , Ruan Junshan 
Published: August 2021

Abstract
Background: Forkhead box (FOX) gene family plays a critical role in regulating Epithelial-mesenchymal transition (EMT) program, and in which, FOXM1 can mediate multiple malignant process in many type of tumor cells. However, the modulate functions of FOXM1 on EMT in non-small-cell lung cancer (NSCLC) cells, especially the transcriptional function on E-cadherin coding gene CDH1 remains unclear. This article mainly focuses on FOXM1, exploring its mechanism in regulating EMT of NSCLC cells, and FOXM1 inhibitor thiostrepton’s effects in EMT intervention. Methods: Morphological changes of overexpressed cells were observed by HE staining. The effects of scratch test, Transwell chamber test and Western-blot analysis on cell migration and invasion ability and the expression of EMT-related markers were analyzed. Dual luciferin reporter enzyme assay and nuclear transcription factor immunoprecipitation assay (ChIP, immunofluorescence) revealed the transcriptional regulation of FOXM1 on EMT markers. MTT assay and clone formation assay were used to determine the effect of thiomycin on the viability of NSCLC cells and the ability of cell clone formation.Rusults: After overexpression of FOXM1, the cells showed intermediate epithelial-mesenchymal morphology, but not complete mesenchymal morphology, and their migration and invasion abilities were enhanced. The protein expression levels of N-cadherin,Snail1 and Vimentin were increased, while the expression levels of E-cadherin were decreased. On the contrary, knockdown of FOXM1 expression showed the opposite result. The double luciferin reporter enzyme assay showed that FOXM1 inhibited the luciferin reporter vector CDH1-2000-promoter. ChIP results confirmed that FOXM1 could bind endogenous to CDH1 gene promoter. In cells overexpressing FOXM1, knockdown of Snail further promotes FOXM1-mediated CDH1 transcription. MTT results and clone formation experiments showed that thiomycin had inhibitory effect on the proliferation of NSCLC cells. Morphological observation, cell migration assay and Transwell chamber assay showed that streptotin inhibited TGF-β1-induced enhanced cell migration and invasion. Western-blot analysis showed that thiomycin down-regulated the expression of FOXM1, N-cadherin, Snail, and Vimentin induced by TGF-β1, while blocking the expression of E-cadherin induced by TGF-β1 decreased.Conclusion: FOXM1 can directly bind to the promoter of E-cadherin encoding gene, and can indirectly inhibit E-cadherin expression by stimulating Snail. Overexpression of FOXM1 can promote EMT progression in NSCLC cells. Therefore, down-regulation of FOXM1 can inhibit this process. In addition, thiostrepton, a FOXM1 inhibitor, blocked proliferation, colony formation, and EMT progression in NSCLC cells.
Closing The Treatment Gap: Insights Into Implementation Strategies for Task-Shared Counselling for Depression and Unhealthy Alcohol use In South Africa
Authors: Brooke-Sumner Carrie , Petersen-Williams Petal , Sorsdahl Katherine , Kruger James , Mahomed Hassan , Myers Bronwyn 
Published: August 2021

Abstract
Background: Task-shared psychological counselling can be an effective approach to meet mental health needs in low-resource settings. Evidence on how to sustain and scale such approaches is required. This study was nested in the Project MIND cluster randomised controlled trial which investigated integrating a new, task-shared counselling service in 24 primary care facilities in South Africa. The current study aimed to describe and distil experiences of primary healthcare managers in whose facilities counselling was implemented.Methods: Focus group discussions and in-depth interviews were conducted with 15 Primary Health Care (PHC) facility and operational managers (urban and rural facilities). Interviewers used a semi-structured topic guide to explore overall experiences of the programme and barriers to wider implementation. Normalisation process theory guided analysis.Results: Managers highlighted their relational work in communicating with staff on the value of the new intervention, to reduce resistance. Their leadership role in promoting support for the intervention, teamwork and onward referral of clients was key to embedding this new approach. Managers emphasized the need for reorientation and upskilling of staff to be foster openness to mental health practice and for counsellors to have adequate time to provide quality counselling. Strengthening within-facility referrals and referrals to external organisations were both noted as crucial for sustained implementation, as well as cycles of monitoring and feedback.Conclusion: This study presents experiences and perceptions of health care managers developed into a multicomponent implementation approach for embedding a task-shared package of care for problem alcohol use and depression in primary care.
Development a New Carbon Nanocomposite Containing MWCNT as Adsorbent for Effective Removal of Cloxacillin
Authors: Golkarieh Amir-Mohammad , Nasirizadeh Navid , Jahanmardi Reza , Jafari Saeed , Dehghani Mohammad 
Published: August 2021

Abstract
Antibiotics along with their metabolites due to their toxicity and low biodegradability have adverse effects to human and animal health. This work can help to monitor and elimination of the residue of the cloxacillin (Clox) antibiotics in two ways: the first part involves design and fabrication of a new electrochemical nanosensor based on a screen-printed carbon electrode modified with gold nanourchin and graphene oxide for detection and determination of Clox in aqueous media. The second part focuses on the preparation of carbon nanocomposites modified with multi-walled carbon nanotubes (MWCNT/CC) as adsorbent for the removal of Clox from aqueous medium. The MWCNT/CC nanocomposites were made using sol-gel process and then the efficiency of the antibiotic removal was assessed by the designed nanosensor. In Clox removal experiments, the effect of independent variables including pH, exposure time, extent of MWCNTs and amount of adsorbent on the removal of antibiotic as a dependent variable was investigated using response surface methodology. The morphological and physical properties of the suggested adsorbent were explored. The maximum efficiency of Clox removal (97%) was achieved in conditions of using 1.52 g/L of the adsorbent fabricated by 2.9 wt. % of MWCNTs in 0.1 M phosphate buffer solution at pH of 5.0 during 75 minutes. The highest adsorption capacity of the MWCNT/CC was 296 mg/g at optimal conditions.
Application of Multi-Criteria Decision Making Models in Forest Fire Management
Authors: Abedi Roya 
Published: August 2021

Abstract
The study on effective factors of forest fire prevention policy is helpful to reduce forest fire impacts on extensive environmental damage in the long-term period. In other words, forest fire management is the result of a complex interaction among criteria. The present study aims to create a scientific analysis of the most effective criteria based on TOPSIS and SAW methods in the Arasbaran forest. The five top optimal criteria selection by TOPSIS method introduced that “association and cooperation between the executive and responsible institutions” have the first rank (CCi+=0.85), “Lack of deterrence law in dealing with forest fire offenders in human–caused forest fires” has the second rank (CCi+= 0.84) and followed by “Lack of up-to-date scientific information on susceptible areas in the region”, “Increasing the cooperation of NGOs and increase public trust”; and “Lack of forest road network access to ignite regions” (CCi+= 0.789; 0.787; 0.77, respectively). The five top optimal criteria resulting from the SAW method showed that “Local people participations” provide the highest score (FS=0.39) and followed by “association and cooperation between the executive and responsible institutions (FS=0.39), “Increasing the cooperation of non-governmental organizations (NGOs) and increase public trust” (FS=0.36), “Raising awareness of the position of natural resources among local peoples and attracting their cooperation” (FS=0.35) and “Optimal Use past experiences” (FS=0.34). It is suggested that evaluating the ecological and environmental factors affecting the forest fire occurrence and extension could become a set of complement factors to setting management criteria for demonstrating the best management strategies.
Lactobacillus Alleviates Colitis Caused by Chemotherapy Via Biofilm Formation
Authors: Qiu Xiaolan , Han Xuedong , Zhang Xiangcheng , Zhen Linlin , Li Zhi , Liu Minmin , Ren Yi , Wang Shui 
Published: August 2021

Abstract
Background: Severe colitis is a common side effect of chemotherapy in cancer patients. A widely consumed probiotic, Lactobacillus, has been reported to alleviate colitis. However, the gastric acid has a powerful bactericidal effect, which restricts to clinical trial success. In this study, we attempted to enhance the viability of probiotics in a gastric acid environment and improve the colitis induced by dextran sulfate sodium (DSS) and chemotherapeutic docetaxel.Methods: We purified Lactobacillus from diverse brands of yogurt and estimated their growth at pH 6.8 and pH 2.0. In the further investigation, the bacterial biofilm formation was used to define the mechanism by which administration of LGG via oral gavage alleviates the colitis and intestine permeability of the mice induced by DSS and docetaxel. The potential benefit of probiotics on the treatment of breast cancer metastasis has been assessed as well.Results: Lactobacillus growth was unexpectedly faster in the pH 2.0 than in the neutral pH medium during the first hour. However, its growth was greatly reduced after the first hour in the pH 2.0 medium but was maintained at neutral pH. As expected, Escherichia coli (E. coli) could not grow well in an acidic medium. Lactobacillus rhamnosus (LGG) administered in the fasting state via oral gavage significantly improved the preventive effect in the colitis caused by DSS and docetaxel. Further mechanistic investigations suggested that LGG reduced the permeability of the intestine and decreased the expression of proinflammatory cytokines, TNFα, IL-1β, and IL-6, in colitis by biofilm formation. We examined the chemotherapeutic effect of docetaxel in a breast cancer model and found that increasing the docetaxel dose may reduce tumor growth and metastasis in the lung but did not benefit survival due to severe colitis. However, the LGG supplement significantly improved the survival of tumor-bearing mice following a high dose of docetaxel treatment. Conclusions: Our findings provide new insights into the potential mechanism of probiotic protection of the intestine and provide a novel therapeutic strategy to augment the chemotherapeutic treatment of tumors.
BRIX1 Promotes Ribosome Synthesis and Enhances Glycolysis by Selected Translation of GLUT1 in Colorectal Cancer
Authors: Jiang Chunhui , Xu Chunjie , Wen Siyuan , Xue Hanbing , Xu Qing 
Published: August 2021

Abstract
Background: Ribosome biogenesis protein BRX1 homolog (BRIX1) is a vital member for synthesizing 60S subunit of ribosome. However, the role and mechanism of BRIX1 in colorectal cancer (CRC) are still unclear. Methods: KEGG pathway analysis and Gene Ontology (GO) analysis were used for bioinformatics analysis. Ribosome RNAs (rRNAs) levels were detected in CRC tissues and cells. Nascent RNA synthesis were detected by cellular immunofluorescence. Correlation was analysis between PET-CT value and BRIX1 expression. Extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) were conducted by seahorse analyses. Polysome fractions were collected for BRIX1 mRNA used in translation. Orthotopic model and CCK-8 assay were used for BRIX1 function in CRC.Results: We found that BRIX1 is a core gene of ribosome-related pathway changes in CRC. GO analysis showed BRIX1 primarily enriched RIBOSOME ASSEMBLY and RIBOSOME BIOGENESIS pathways. In fresh CRC tissue, rRNAs levels (5S, 5.8S, 18S and 28S) were obvious higher in BRIX1-high group than BRIX1-Low group. Similarly, BRIX1 knockdown and overexpression significantly dereased and increased rRNAs levels (5S, 5.8S, 18S and 28S) in CRC cells, respectively. In addition, BRIX1 knockdown inhibited nascent RNA synthesis of CRC cells. In clinical data analysis, we found that BRIX1 expression is related to the glucose uptake of PET-CT. Consistently, BRIX1 knockdown and overexpression significantly dereased and increased ECAR valve, glucose uptake and lactic acid production in CRC cells. Subsequently, we found BRIX1 knockdown and overexpression significantly dereased and increased the protein expression of GLUT1, but not affect its mRNA expression. Interestingly, we found BRIX1 knockdown and overexpression obviously decreased and increased mRNA level of GLUT1 in polysome fractions. Blocking glycolysis by si-GLUT1 or galactose reversed the promoting role of BRIX1 in glycolysis and cell proliferation of CRC cells. Conclusion: In this study, BRIX1 plays a tumor-promoting role in CRC via regulating glycolysis by selecting GLUT1 translation, indicating a correlation between ribosome activation and metabolic reprogramming in CRC.
Comprehensive Analysis of the Prognostic Value and Immune Infiltration of Calpains in Pancreatic Cancer
Authors: Chuan Lan , Tang Haoyou , Liu Sheng , Ma Lin , Hou Yifu 
Published: August 2021

Abstract
Background: Calpains (CAPNs) are intracellular calcium-activated neutral cysteine proteinases that are involved in cancer initiation, progression, and metastasis; however, their role in pancreatic cancer (PC) remains unclear. Methods: We combined data from various mainstream databases (i.e., Oncomine, GEPIA, Kaplan-Meier plotter, cBioPortal, STRING, GeneMANIA, and ssGSEA) and investigated the role of CAPNs in the prognosis of PC and immune cell infiltration.Results: Our results showed that CAPN1, 2, 4, 5, 6, 8, 9, 10, and 12 were highly expressed in PC. The expression levels of CAPN1, 5, 8, and 12 were positively correlated with the individual cancer stages. Moreover, the expression levels of CAPN1, 2, 5, and 8 were negatively correlated with the overall survival (OS) and recurrence-free survival (RFS); whereas that of CAPN10 was positively correlated with OS and RFS. We found that CAPN1, 2, 5, and 8 were correlated with tumour-infiltrating T follicular helper cells and CAPN10 with tumour-infiltrating T helper 2 cells. Functional enrichment analysis showed that the differentially expressed CAPNs (CAPN1, 2, 5, 8, and 10) are involved in axonogenesis, cell-substrate adhesion, immune response-activating cell surface receptor signalling pathway, and cell junction organisation in PC.Conclusions: These results suggested that CAPN1, 2, 5, 8, and 10 could be used as prognostic biomarkers in PC and can assist in improving individualised treatment strategies.
Fucoidan from Sargassum Hemiphyllum Inhibits Infection and Inflammation of Helicobacter Pylori
Authors: Chen Bo-Rui , Li Wei-Ming , Li Tsung-Lin , Chan Yi-Lin , Wu Chang-Jer 
Published: August 2021

Abstract
When infected by Helicobacter pylori, it often causes gastritis, gastric ulcer, or gastric cancer. Antibiotics are used to treat H. pylori infection, as they inhibit or kill H. pylori often ex-tending to reduce the incidences of gastric adenoma and cancer. However, H. pylori has developed drug resistance to many clinically used antibiotics over the years, thereby providing no warranty of successful treatment whenever H. pylori infection befalls. We report here that fucoidan from Sargassumhemiphyllum can effectively reduce infection of H. pylori without development of drug resistance. Fucoidan demonstrated a strong anti-inflammation activity in RAW264.7 cell model. Using AGS cell model, fucoidan decreased H. pylori adhesion to host cells and thus reduced its infection rate, especially in post-treatment where the infection rate was reduced to 40%. Mechanistically, fucoidan intervenes the proper functions of adhesion molecules BabA and AlpA of H. pylori. Moreover, fucoidan is able to significantly lower the total count of H. pylori and the levels of IL-6 and TNF-α in vivo. Added together, these convergent results suggest that fucoidan is an effective agent in a position to protect stomach from H. pylori infection by reducing its total count and induced inflammation.