bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coal-derived humic acid for application in acid mine drainage (AMD) water treatment and electrochemical devices
Authors: Das Tonkeswar , Bora Mousumi , Tamuly Joyshil , Benoy Santhi Maria , Baruah Bimala P. , Saikia Prasenjit , Saikia Binoy K. 
Published: June 2021

AbstractIn this research work, isolation of humic acid from coal of Northeastern region of India is reported. The study is also targeted for application of the coal-derived humic acid in acid mine drainage (AMD) water treatment and electrochemical devices. All the obtained results are compared with the standard humic acid and examined the formation of humic acid from the coal. The isolated coal-derived humic acid is found to be high degree of humifications and relatively stable up to about 200 °C. The FTIR study indicates the formation of metal-humic acid complexes. On treatment with acidic water (AMD), the coal-derived humic acid was found to have the ability to remove toxic metal such as (in order) Pb > Cu > Zn > Cd. In addition, the preliminary electrochemical properties of the isolated humic acid are also discussed in the paper. The specific capacitance of the isolated coal-derived humic acid via cyclic voltammetry and charge-discharge analysis is found to be 7 mF/g at scan rate 10 mV/s and 22 mF/g within the potential window 0.4 V, respectively. The charge-discharge cycles are stable for more than 1000 cycles within the potential window 0.4 V. This study will create a new pathway for the further research in this field.
Sample paths of white noise in spaces with dominating mixed smoothness
Authors: Hummel Felix 
Published: June 2021

AbstractThe sample paths of white noise are proved to be elements of certain Besov spaces with dominating mixed smoothness. Unlike in isotropic spaces, here the regularity does not get worse with increasing space dimension. Consequently, white noise is actually much smoother than the known sharp regularity results in isotropic spaces suggest. An application of our techniques yields new results for the regularity of solutions of Poisson and heat equation on the half space with boundary noise. The main novelty is the flexible treatment of the interplay between the singularity at the boundary and the smoothness in tangential, normal and time direction.
Ecophenotypic plasticity in shell growth direction of asari clamRuditapes philippinarum
Authors: Tomiyama Takeshi 
Published: June 2021

AbstractAsari clam (or Manila clam)Ruditapes philippinarumis an important bivalve for local fisheries. This species exhibits a large variation in shell morphology, and the shell roundness tends to be greater in more unsuitable habitats. To test whether the increments in shell size parameters (length, height and width) were affected solely by environmental conditions or by internal factors such as initial shell shapes or growth rate, a field caging experiment was conducted at two different sites of unsuitable and suitable habitats in Matsukawaura Lagoon, Japan, where shell shapes of wild clams were significantly different between the habitats. In the experiment, clams were released from the two sites to the same site or to the other site and were re-collected after 3, 6 and 12 months of caging. Caged clams originating from unsuitable habitats and released to suitable habitats showed a reduction in shell height relative to shell length, while clams from suitable habitats introduced to unsuitable habitats showed marked increases in both shell height and width. Generalized linear mixed models suggested that the increase in shell height was affected largely by the release habitat (environment) whereas the increase in shell width was affected largely by the individual growth rate. These results suggest that marginal growths in shell height and width respond differently to external and internal factors of clams, resulting in plasticity in their shell shapes according to the environments to which they are translocated.
Learning-based simulation and modeling of unorganized chaining behavior using data generated from 3D human motion tracking
Authors: Malviya Abhinav , Kala Rahul 
Published: June 2021

AbstractThe paper models the unorganized chaining behavior, where humans need to walk in a chain due to a constrained environment. Detection and tracking are done using a 3D LiDAR, which has the challenges of environmental noises, uncontrolled environment, and occlusions. The Kalman filter is used for tracking. The trajectories are analyzed and used to train a behavioral model. The modeling has applications in socialistic robot motion planning and simulations. Based on the results, we conclude that the trajectory prediction by our approach is more socialistic and has a lesser error when compared to the artificial potential field method.
COVID-19 pandemic as a risk factor for the reactivation of herpes viruses
Authors: Maldonado M. D. , Romero-Aibar J. , Pérez-San-Gregorio M. A. 
Published: June 2021

Abstract
The appearance on the skin of herpes virus lesions, concomitantly with the coronavirus disease 2019 (COVID-19) pandemic, leads us to suspect an underlying infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Diagnostic reverse transcriptase polymerase chain reaction tests and immunoglobulin M (IgM) and IgG seroconversion studies have therefore been carried out. We present three cases of herpes virus infections in immunocompetent patients: one of the infections was herpes simplex 1 in a 40-year-old woman, and the other two were herpes varicella-zoster infections in a 62-year-old man and a 25-year-old woman. The patients were in the care of the southern health district of Seville of the SAS (Andalusian Health Service) during the Spanish state of alarm over the COVID-19 pandemic. The SARS-CoV-2 infection was confirmed in only one of the three cases. In this study, we briefly review the etiopathogenic role of the COVID-19 pandemic situation, whereby immunodeficiencies are generated that favour the appearance of other viral infections, such as herpes virus infections.
Fast sparse image reconstruction method in through-the-wall radars using limited memory Broyden–Fletcher–Goldfarb–Shanno algorithm
Authors: Mwisomba Candida , Abdalla Abdi T. , Amour Idrissa , Mkemwa Florian , Maiseli Baraka 
Published: June 2021

AbstractCompressed sensing allows recovery of image signals using a portion of data – a technique that has drastically revolutionized the field of through-the-wall radar imaging (TWRI). This technique can be accomplished through nonlinear methods, including convex programming and greedy iterative algorithms. However, such (nonlinear) methods increase the computational cost at the sensing and reconstruction stages, thus limiting the application of TWRI in delicate practical tasks (e.g. military operations and rescue missions) that demand fast response times. Motivated by this limitation, the current work introduces the use of a numerical optimization algorithm, called Limited Memory Broyden–Fletcher–Goldfarb–Shanno (LBFGS), to the TWRI framework to lower image reconstruction time. LBFGS, a well-known Quasi-Newton algorithm, has traditionally been applied to solve large scale optimization problems. Despite its potential applications, this algorithm has not been extensively applied in TWRI. Therefore, guided by LBFGS and using the Euclidean norm, we employed the regularized least square method to solve the cost function of the TWRI problem. Simulation results show that our method reduces the computational time by 87% relative to the classical method, even under situations of increased number of targets or large data volume. Moreover, the results show that the proposed method remains robust when applied to noisy environment.
The Face of the Problem: How Subordinates Shield Executives from Blame
Authors: Croco Sarah E. , McDonald Jared , Turitto Candace 
Published: June 2021

AbstractThough avoiding blame is often a goal of elected officials, there are relatively few empirical examinations of how citizens assign blame during controversies. We are particularly interested in how this process works when an executive has been caught in a lie. Using two survey experiments, we examine whether subordinates can shield executives when they act as the face of a crisis. We first leverage a real-life situation involving the family separation crisis at the US–Mexico border in 2018. Respondents who read that Donald Trump falsely claimed he could not end the practice of family separation disapprove of his dishonesty. Yet this cost disappears when Trump’s then-Secretary of Homeland Security, Kirstjen Nielsen, is the primary official discussed in news stories. We then replicate these findings in a fictional scenario involving a city mayor, showing that the mayor is partially shielded from negative appraisals when the city manager lies on his behalf.
Tumor microenvironment and radioresistance
Authors: Suwa Tatsuya , Kobayashi Minoru , Nam Jin-Min , Harada Hiroshi 
Published: June 2021

AbstractMetastasis is not the result of a random event, as cancer cells can sustain and proliferate actively only in a suitable tissue microenvironment and then form metastases. Since Dr. Stephen Paget in the United Kingdom proposed the seed and soil hypothesis of cancer metastasis based on the analogy that plant seeds germinate and grow only in appropriate soil, considerable attention has focused on both extracellular environmental factors that affect the growth of cancer cells and the tissue structure that influences the microenvironment. Malignant tumor tissues consist of not only cancer cells but also a wide variety of other cells responsible for the inflammatory response, formation of blood vessels, immune response, and support of the tumor tissue architecture, forming a complex cellular society. It is also known that the amounts of oxygen and nutrients supplied to each cell differ depending on the distance from tumor blood vessels in tumor tissue. Here, we provide an overview of the tumor microenvironment and characteristics of tumor tissues, both of which affect the malignant phenotypes and radioresistance of cancer cells, focusing on the following keywords: diversity of oxygen and nutrient microenvironment in tumor tissue, inflammation, immunity, and tumor vasculature.
Hypoxic–ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina
Authors: Zaitoun Ismail S. , Shahi Pawan K. , Suscha Andrew , Chan Kore , McLellan Gillian J. , Pattnaik Bikash R. , Sorenson Christine M. , Sheibani Nader 
Published: June 2021

AbstractIschemic stroke is a major cause of long-term disabilities, including vision loss. Neuronal and blood vessel maturation can affect the susceptibility of and outcome after ischemic stroke. Although we recently reported that exposure of neonatal mice to hypoxia–ischemia (HI) severely compromises the integrity of the retinal neurovasculature, it is not known whether juvenile mice are similarly impacted. Here we examined the effect of HI injury in juvenile mice on retinal structure and function, in particular the susceptibility of retinal neurons and blood vessels to HI damage. Our studies demonstrated that the retina suffered from functional and structural injuries, including reduced b-wave, thinning of the inner retinal layers, macroglial remodeling, and deterioration of the vasculature. The degeneration of the retinal vasculature associated with HI resulted in a significant decrease in the numbers of pericytes and endothelial cells as well as an increase in capillary loss. Taken together, these findings suggest a need for juveniles suffering from ischemic stroke to be monitored for changes in retinal functional and structural integrity. Thus, there is an emergent need for developing therapeutic approaches to prevent and reverse retinal neurovascular dysfunction with exposure to ischemic stroke.
Unsteady hybrid-nanofluid flow comprising ferrousoxide and CNTs through porous horizontal channel with dilating/squeezing walls
Authors: Bilal Muhammad , Arshad Hamna , Ramzan Muhammad , Shah Zahir , Kumam Poom 
Published: June 2021

AbstractThe key objective of the present research is to examine the hybrid magnetohydrodynamics (MHD) nanofluid (Carbon-nanotubes and ferrous oxide–water) CNT–Fe3O4/H2 flow into a horizontal parallel channel with thermal radiation through squeezing and dilating porous walls. The parting motion is triggered by the porous walls of the channel. The fluid flow is time-dependent and laminar. The channel is asymmetric and the upper and lower walls are distinct in temperature and are porous. With the combination of nanoparticles of Fe3O4 and single and multi-wall carbon nanotubes, the hybrid nanofluid principle is exploited. By using the similarity transformation, the set of partial differential equations (PDEs) of this mathematical model, governed by momentum and energy equations, is reduced to corresponding ordinary differential equations (ODEs). A very simple numerical approach called the Runge–Kutta system of order four along with the shooting technique is used to achieve the solutions for regulating ODEs. MATLAB computing software is used to create temperature and velocity profile graphs for various emerging parameters. At the end of the manuscript, the main conclusions are summarized. Through different graphs, it is observed that hybrid-nanofluid has more prominent thermal enhancement than simple nanofluid. Further, the single-wall nanotubes have dominated impact on temperature than the multi-wall carbon nanotubes. From the calculations, it is also noted that Fe2O3–MWCNT–water has an average of 4.84% more rate of heat transfer than the Fe2O3–SWCNT–water. On the other hand, 8.27% more heat flow observed in Fe2O3–SWCNT–water than the simple nanofluid. Such study is very important in coolant circulation, inter-body fluid transportation, aerospace engineering, and industrial cleaning procedures, etc.
Nostalgia enhances detection of death threat: neural and behavioral evidence
Authors: Yang Ziyan , Sedikides Constantine , Izuma Keise , Wildschut Tim , Kashima Emiko S. , Luo Yu L. L. , Chen Jun , Cai Huajian 
Published: June 2021

AbstractAn experiment examined the potency of nostalgia—a sentimental longing for one’s past—to facilitate detection of death-related stimuli, using functional magnetic resonance imaging (fMRI) and behavioral techniques (i.e., judgmental accuracy, reaction times). We hypothesized and found that, at the neural level, nostalgic (relative to control) participants evinced more intense activation in right amygdala in response to death-related (vs. neutral) words. We also hypothesized and found that, at the behavioral level, nostalgic (relative to control) participants manifested greater accuracy in judging whether two death-related (vs. neutral) words belonged in the same category. Exploratory analyses indicated that nostalgic (relative to control) participants did not show faster reaction times to death-related (vs. neutral) words. In all, nostalgia appeared to aid in death threat detection. We consider implications for the relevant literatures.
Environmental DNA reveals arboreal cityscapes at the Ancient Maya Center of Tikal
Authors: Lentz David L. , Hamilton Trinity L. , Dunning Nicholas P. , Tepe Eric J. , Scarborough Vernon L. , Meyers Stephanie A. , Grazioso Liwy , Weiss Alison A. 
Published: June 2021

AbstractTikal, a major city of the ancient Maya world, has been the focus of archaeological research for over a century, yet the interactions between the Maya and the surrounding Neotropical forests remain largely enigmatic. This study aimed to help fill that void by using a powerful new technology, environmental DNA analysis, that enabled us to characterize the site core vegetation growing in association with the artificial reservoirs that provided the city water supply. Because the area has no permanent water sources, such as lakes or rivers, these reservoirs were key to the survival of the city, especially during the population expansion of the Classic period (250–850 CE). In the absence of specific evidence, the nature of the vegetation surrounding the reservoirs has been the subject of scientific hypotheses and artistic renderings for decades. To address these hypotheses we captured homologous sequences of vascular plant DNA extracted from reservoir sediments by using a targeted enrichment approach involving 120-bp genetic probes. Our samples encompassed the time before, during and after the occupation of Tikal (1000 BCE–900 CE). Results indicate that the banks of the ancient reservoirs were primarily fringed with native tropical forest vegetation rather than domesticated species during the Maya occupation.
African forest elephant movements depend on time scale and individual behavior
Authors: Beirne Christopher , Houslay Thomas M. , Morkel Peter , Clark Connie J. , Fay Mike , Okouyi Joseph , White Lee J. T. , Poulsen John R. 
Published: June 2021

AbstractThe critically endangered African forest elephant (Loxodonta cyclotis) plays a vital role in maintaining the structure and composition of Afrotropical forests, but basic information is lacking regarding the drivers of elephant movement and behavior at landscape scales. We use GPS location data from 96 individuals throughout Gabon to determine how five movement behaviors vary at different scales, how they are influenced by anthropogenic and environmental covariates, and to assess evidence for behavioral syndromes—elephants which share suites of similar movement traits. Elephants show some evidence of behavioral syndromes along an ‘idler’ to ‘explorer’ axis—individuals that move more have larger home ranges and engage in more ‘exploratory’ movements. However, within these groups, forest elephants express remarkable inter-individual variation in movement behaviours. This variation highlights that no two elephants are the same and creates challenges for practitioners aiming to design conservation initiatives.
Pre-motor versus motor cerebral cortex neuromodulation for chronic neuropathic pain
Authors: Lavrov Igor , Latypov Timur , Mukhametova Elvira , Lundstrom Brian N. , Sandroni Paola , Lee Kendall , Klassen Bryan , Stead Matt 
Published: June 2021

AbstractElectrical stimulation of the cerebral cortex (ESCC) has been used to treat intractable neuropathic pain for nearly two decades, however, no standardized approach for this technique has been developed. In order to optimize targeting and validate the effect of ESCC before placing the permanent grid, we introduced initial assessment with trial stimulation, using a temporary grid of subdural electrodes. In this retrospective study we evaluate the role of electrode location on cerebral cortex in control of neuropathic pain and the role of trial stimulation in target-optimization for ESCC. Location of the temporary grid electrodes and location of permanent electrodes were evaluated in correlation with the long-term efficacy of ESCC. The results of this study demonstrate that the long-term effect of subdural pre-motor cortex stimulation is at least the same or higher compare to effect of subdural motor or combined pre-motor and motor cortex stimulation. These results also demonstrate that the initial trial stimulation helps to optimize permanent electrode positions in relation to the optimal functional target that is critical in cases when brain shift is expected. Proposed methodology and novel results open a new direction for development of neuromodulation techniques to control chronic neuropathic pain.
In vitro safety evaluation of rare earth-lean alloys for permanent magnets manufacturing
Authors: Rumbo Carlos , Espina Cristina Cancho , Gassmann Jürgen , Tosoni Olivier , Barros García Rocío , Martín Sonia Martel , Tamayo-Ramos Juan Antonio 
Published: June 2021

AbstractDue to their exceptional physico-chemical and magnetic characteristics, rare earth (RE) permanent magnets are applied in multiple critical technologies. However, several environmental and economic difficulties arising from obtaining RE elements have prompted the search of alternatives with acceptable magnetic properties but containing a lower percentage of these elements in their composition. The aim of this work was to perform a preliminary toxicological evaluation of three forms of newly developed RE-lean alloys (one NdFeTi and two NdFeSi alloys) applying different in vitro assays, using as a benchmark a commercial NdFeB alloy. Thus, the effects of the direct exposure to powder suspensions and to their derived leachates were analysed in two model organisms (the A549 human cell line and the yeast Saccharomyces cerevisiae) applying both viability and oxidative stress assays. Moreover, the impact of the alloy leachates on the bioluminescence of Vibrio fischeri was also investigated. The obtained data showed that only the direct interaction of the alloys particulates with the applied organisms resulted in harmful effects, having all the alloys a comparable toxicological potential to that presented by the reference material in the conditions tested. Altogether, this study provides new insights about the safety of NdFeTi and NdFeSi alloys.
Toxicity evaluation of ConvitVax breast cancer immunotherapy
Authors: Duarte C. María A. , Carballo O. Jeismar M. , De Gouveia Yetsenia M. , García Angie , Ruiz Diana , Gledhill Teresa , González-Marcano Eglys , Convit Ana F. 
Published: June 2021

AbstractConvitVax is a personalized vaccine for the treatment of breast cancer, composed of autologous tumor cells, bacillus Calmette-Guérin (BCG) and low concentrations of formalin. Previous pre-clinical studies show that this therapy induces a potent activation of the immune system and achieves an effective response against tumor cells, reducing the size of the tumor and decreasing the percentage of immunosuppressive cells. In the present study, we evaluate the toxicity of ConvitVax in healthy BALB/c mice to determine potential adverse effects related to the vaccine and each of its components. We used standard guidelines for pain, discomfort and distress recognition, continuously evaluated the site of the injection, and completed blood and urine clinical tests. Endpoint necropsy was performed, measuring the weight of organs and processing liver, kidney, thymus and lung for histological examination. Results show that the vaccine in its therapeutic dose, at 3 times its therapeutic concentration, and its individual components did not cause death or behavioral or biological changes, including any abnormalities in whole-body or organ weights, and tissue damage. These results support the safety of ConvitVax with minimal to no side-effects.
Socioeconomic position links circulatory microbiota differences with biological age
Authors: Craven Hannah , McGuinness Dagmara , Buchanan Sarah , Galbraith Norman , McGuinness David H. , Jones Brian , Combet Emilie , Mafra Denise , Bergman Peter , Ellaway Anne , Stenvinkel Peter , Ijaz Umer Z. , Shiels Paul G. 
Published: June 2021

AbstractImbalanced nutrition is associated with accelerated ageing, possibly mediated by microbiota. An analysis of the circulatory microbiota obtained from the leukocytes of participants in the MRC Twenty-07 general population cohort was performed. We now report that in this cohort, the most biologically aged exhibit a significantly higher abundance of circulatory pathogenic bacteria, including Neisseria, Rothia and Porphyromonas, while those less biologically aged possess more circulatory salutogenic (defined as being supportive of human health and wellbeing) bacteria, including Lactobacillus, Lachnospiraceae UCG-004 and Kocuria. The presence of these salutogenic bactreria is consistent with a capacity to metabolise and produce Nrf2 agonists. We also demonstrate that associated one carbon metabolism, notably betaine levels, did not vary with chronological age, but displayed a difference with socioeconomic position (SEP). Those at lower SEP possessed significantly lower betaine levels indicative of a poorer diet and poorer health span and consistent with reduced global DNA methylation levels in this group. Our data suggest a clear route to improving age related health and resilience based on dietary modulation of the microbiota.