bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and implementation of a standard care programme of therapeutic exercise and education for breast cancer survivors
Authors: Roldán-Jiménez Cristina , Pajares Bella , Ruiz-Medina Sofía , Trinidad-Fernández Manuel , González-Sánchez Manuel , Ribelles Nuria , García-Almeida José Manuel , Ríos-López María José , Alba Emilio , Cuesta-Vargas Antonio Ignacio 
Published: August 2021

Abstract
Background
Breast cancer survivors (BCS) face several symptoms and are at higher risk of weight gain following diagnosis. Current literature shows that both exercise and diet play a key role in recovery of BCS. However, there is a gap between current guidelines and the real-world context. The aim of this article is to describe the process behind a free, not-for-profit community-based therapeutic exercise and education programme (TEEP) for BCS in the clinical setting.

Methods
The “Onco-Health Club” (OHC) consists of therapeutic exercise (TE) intervention aimed at ameliorating cancer-related fatigue (CRF) and improving QoL and physical function. TE is supplemented with nutritional education, providing information about the Mediterranean diet. To this end, patients are recruited from an oncologist and are referred to a physiotherapist and a nutritionist for baseline assessment. TEEP consists of a 3-month intervention, delivered twice a week in a group format with 1 h of TE and 30 min of nutritional education. BCS then have a final assessment and are advised to continue with a healthy lifestyle. Data about referral, compliance and assessment were collected.

Results
From May 2017 to February of 2020, a total of 158 patients were recruited from 8 cohorts and 142 initially started the OHC. From 119 that joined the program, 96 patients were considered to have finished it with good adherence (assistance > 80%). BCS significantly improved their QoL, as well as upper and lower limb’s function, and increased their level of physical activity. CRF tended to decrease (p = 0.005).

Conclusions
This study obtained data on recruitment, compliance, and possible limitations of these kinds of programmes in a real-world context. Further research is needed in order to optimize patient engagement and compliance, as well as to determine the transferability of these programmes in the clinical setting.

Trial registration
NCT03879096, Registered 18th March 2019. Retrospectively registered.
The change of hydrological variables and its effects on vegetation in Central Asia
Authors: Peng Qing , Wang Ranghui , Jiang Yelin , Li Cheng , Guo Wenhui 
Published: August 2021

AbstractWater is an important factor that affects local ecological environments, especially in drylands. The hydrological cycle and vegetation dynamics in Central Asia (CA) have been severely affected by climate change. In this study, we employed data from Gravity Recovery and Climate Experiment (GRACE), Global Land Data Assimilation System (GLDAS), Global Land Evaporation Amsterdam Model, and Climate Research Unit to analyze the spatiotemporal changes in hydrological factors (terrestrial water storage (TWS), evapotranspiration, precipitation, and groundwater) in CA from 2003 to 2015. Additionally, the spatiotemporal changes in vegetation dynamics and the influence of hydrological variables on vegetation were analyzed. The results showed that the declining rates of precipitation, evapotranspiration, GRACE-TWS change, GLDAS-TWS change and GW change were 0.40 mm/year, 0.11 mm/year, 50.46 mm/year (p < 0.05), 8.38 mm/year, and 41.18 mm/year (p < 0.05), respectively. Human activity (e.g., groundwater pumping) was the dominant in determining the GW decline in CA. Precipitation dominated the changes in evapotranspiration, GRACE-TWS and GLDAS-TWS (p < 0.05). The 2- to 3-month lagging signal has to do with the transportation from the ground surface to groundwater. The change in the normalized difference vegetation index (NDVI) from 2003 to 2015 indicated the slight vegetation degradation in CA. The results highlighted that precipitation, terrestrial water storage, and soil moisture make important contributions to the vegetation dynamics changes in CA. The effect of precipitation on vegetation growth in spring was significant (p < 0.05), while the soil moisture effect on vegetation in summer and autumn was higher than that of precipitation.
Deep ReLU network expression rates for option prices in high-dimensional, exponential Lévy models
Authors: Gonon Lukas , Schwab Christoph 
Published: August 2021

AbstractWe study the expression rates of deep neural networks (DNNs for short) for option prices written on baskets of $d$
d
risky assets whose log-returns are modelled by a multivariate Lévy process with general correlation structure of jumps. We establish sufficient conditions on the characteristic triplet of the Lévy process $X$
X
that ensure $\varepsilon $
ε
error of DNN expressed option prices with DNNs of size that grows polynomially with respect to ${\mathcal{O}}(\varepsilon ^{-1})$
O
(

ε

−
1

)
, and with constants implied in ${\mathcal{O}}(\, \cdot \, )$
O
(

⋅

)
which grow polynomially in $d$
d
, thereby overcoming the curse of dimensionality (CoD) and justifying the use of DNNs in financial modelling of large baskets in markets with jumps.In addition, we exploit parabolic smoothing of Kolmogorov partial integro-differential equations for certain multivariate Lévy processes to present alternative architectures of ReLU (“rectified linear unit”) DNNs that provide $\varepsilon $
ε
expression error in DNN size ${\mathcal{O}}(|\log (\varepsilon )|^{a})$
O
(

|
log
(
ε
)
|

a

)
with exponent $a$
a
proportional to $d$
d
, but with constants implied in ${\mathcal{O}}(\, \cdot \, )$
O
(

⋅

)
growing exponentially with respect to $d$
d
. Under stronger, dimension-uniform non-degeneracy conditions on the Lévy symbol, we obtain algebraic expression rates of option prices in exponential Lévy models which are free from the curse of dimensionality. In this case, the ReLU DNN expression rates of prices depend on certain sparsity conditions on the characteristic Lévy triplet. We indicate several consequences and possible extensions of the presented results.
Review: Saltwater intrusion in fractured crystalline bedrock
Authors: Giese Markus , Barthel Roland 
Published: August 2021

AbstractDuring the past few years, the number of regional and national assessments of groundwater quality in regard to saltwater intrusion in coastal aquifers has increased steadily. However, most of the international literature on saltwater intrusion is focused on coastal plains with aquifers in unconsolidated material. Case studies, modelling approaches and parameter studies dealing with saltwater intrusion in those systems are abundant. While the hydrogeology of fractured rock has been intensively studied with both modelling approaches and parameter studies—mainly in relation to deep-laying fractured crystalline bedrock as potential waste repositories—case studies on saltwater intrusion in shallow fractured rocks are still an exception. This review summarizes the actual knowledge on saltwater intrusion in fractured crystalline rock. In combination with short overviews of the processes of saltwater intrusion, flow in fractured systems and the genesis of these systems, the review highlights the importance of the fracture systems and its specific characteristics. Fracture properties are a direct consequence of the geological history as well as the current situation of the coastal area. A holistic assessment of water quality in coastal areas hosting fractured crystalline bedrock therefore requires the combination of different approaches in order to investigate the impact of saltwater intrusion through the fractured system.
Query answering in circumscribed OWL2 profiles
Authors: Bonatti Piero A. 
Published: August 2021

AbstractThis paper partially bridges a gap in the literature on Circumscription in Description Logics by investigating the tractability of conjunctive query answering in OWL2’s profiles. It turns out that the data complexity of conjunctive query answering is coNP-hard in circumscribed$\mathcal {E}{\mathscr{L}}$ELandDL-lite, while in circumscribed OWL2-RL conjunctive queries retain their classical semantics. In an attempt to capture nonclassical inferences in OWL2-RL, we consider conjunctive queries with safe negation. They can detect some of the nonclassical consequences of circumscribed knowledge bases, but data complexity becomes coNP-hard. In circumscribed$\mathcal {E}{\mathscr{L}}$EL, answering queries with safe negation is undecidable.
Predicting Future Service Use in Dutch Mental Healthcare: A Machine Learning Approach
Authors: van Mens Kasper , Kwakernaak Sascha , Janssen Richard , Cahn Wiepke , Lokkerbol Joran , Tiemens Bea 
Published: August 2021

AbstractA mental healthcare system in which the scarce resources are equitably and efficiently allocated, benefits from a predictive model about expected service use. The skewness in service use is a challenge for such models. In this study, we applied a machine learning approach to forecast expected service use, as a starting point for agreements between financiers and suppliers of mental healthcare. This study used administrative data from a large mental healthcare organization in the Netherlands. A training set was selected using records from 2017 (N = 10,911), and a test set was selected using records from 2018 (N = 10,201). A baseline model and three random forest models were created from different types of input data to predict (the remainder of) numeric individual treatment hours. A visual analysis was performed on the individual predictions. Patients consumed 62 h of mental healthcare on average in 2018. The model that best predicted service use had a mean error of 21 min at the insurance group level and an average absolute error of 28 h at the patient level. There was a systematic under prediction of service use for high service use patients. The application of machine learning techniques on mental healthcare data is useful for predicting expected service on group level. The results indicate that these models could support financiers and suppliers of healthcare in the planning and allocation of resources. Nevertheless, uncertainty in the prediction of high-cost patients remains a challenge.
Business Model Involvement, Adaptive Capacity, and the Triple Bottom Line at the Base of the Pyramid
Authors: Verwaal Ernst , Klein Martin , La Falce Jefferson 
Published: August 2021

AbstractAlmost two decades ago, Prahalad and Hammond [Harv Bus Rev, 80(9):48–59, 2002] introduced the base/bottom of the pyramid (BOP) approach to profitably serving the poor with business models adapted from developed markets while alleviating poverty. In response to disappointing results and ethical criticism, the BOP approach evolved from a just-for-profit approach with a passive role of the poor to an inclusive development approach that integrates the principles of the triple bottom line. A recent review of the BOP literature [Dembek et al., J Bus Ethics 165(3):365–382, 2020], however, reveals a lack of empirical evidence to support the sustainable BOP approach. In this paper, we specify the assumptions underlying the sustainable BOP approach and test them using structural equation modeling with clustered robust standard errors on a unique dataset of 212 firms. Our findings show that BOP business model involvement and adaptive capacity are significant drivers of the triple bottom line at the BOP; however, business model adaptive capacity does not guarantee an ecologically sustainable performance at the BOP. We find that there is a need for further extension of the ethical foundations of the sustainable BOP approach.
The Development of Polydimethysiloxane/ZnO–GO Antifouling Coatings
Authors: Zhang Xiaoxue , Årstøl Erland , Nymark Marianne , Fages-Lartaud Maxime , Mikkelsen Øyvind 
Published: August 2021

Abstract
The development of antifouling coating for sensor is desirable because the biofilm can shorten sensor’s life and cause inaccurate reading. In this study, a facile one-pot reaction was used to synthesized ZnO–graphene oxide (GO) (ZnO–GO) nanocomposites. Different amount of ZnO–GO was incorporated in the polydimethylsiloxane (PDMS) matrix respectively though a simple solution mixing method, in order to create PDMS/ZnO–GO nanocomposite (PZGO). The coating was obtained directly by spin coating of PZGO/tetrahydrofuran suspension. The hydrophobicity, surface roughness (Ra), surface free-energy (SFE) and nanoscale structure were investigated as antifouling factors. Antifouling tests were performed using two marine microorganisms, the cyanobacterium Synechococcus sp. Strain PCC 7002 and the diatom Phaeodactylum tricornutum. PZGO0.2 (mass ratio of ZnO–GO to PDMS: 0.2 wt%) displayed excellent antifouling property with 8.5% of Synechococcus sp. Strain PCC 7002 biofilm coverage, while PZGO0.1 (mass ratio of ZnO–GO to PDMS: 0.1 wt%) showed 2.4% P. tricornutum biofilm coverage. The antifouling property of the synthesized PZGO nanocomposite can be attributed to its high Ra and hydrophobicity which was caused by the good dispersion of ZnO–GO in PDMS matrix. This study suggests a potential of PZGO nanocomposite for sensor’s antifouling coating, which could contribute to improve sensor’s durability relating to biofouling in future.

Graphic Abstract
Types of boredom and other learning activity emotions: A person-centred investigation of inter-individual data
Authors: Tempelaar Dirk , Niculescu Alexandra Corina 
Published: August 2021

AbstractWhether boredom is a unitary construct or if multiple types of boredom exist is a long-standing debate. Recent research has established the existence of boredom types based on frequency observations of boredom by experience sampling. This work tries to expand our understanding of boredom and replicate these previous findings by applying intensity observations of cross-sectional type for four discrete learning activity emotions: boredom, anxiety, hopelessness, and enjoyment. Latent class analysis based on activity emotion scores from 9863 first-year students of a business and economics program results in seven profiles. Five of these profiles allow a linear ordering from low to high control and value scores (the direct antecedents of emotions), low to high positive, and high to low negative emotions. Two profiles differ from this pattern: one ‘high boredom’ profile and one ‘low boredom’ profile. We next compare antecedent relationships of activity emotions at three different levels: inter-individual, inter-class or between classes, and intra-class or within classes. Some of these relationships are invariant for the choice of level of analysis, such as hopelessness. Other relationships, such as boredom, are highly variant: within-class relationships differ from inter-individual relationships. Indeed, our results confirm that boredom is not a unitary construct. The types of boredom found and their implications for educational practice are discussed and shared in this article.
Near-resonant dynamics, period doubling and chaos of a 3-DOF vibro-impact system
Authors: Fritzkowski Pawel , Awrejcewicz Jan 
Published: August 2021

AbstractA mechanical system composed of two weakly coupled oscillators under harmonic excitation is considered. Its main part is a vibro-impact unit composed of a linear oscillator with an internally colliding small block. This block is coupled with the secondary part being a damped linear oscillator. The mathematical model of the system has been presented in a non-dimensional form. The analytical studies are restricted to the case of a periodic steady-state motion with two symmetric impacts per cycle near 1:1 resonance. The multiple scales method combined with the sawtooth-function-based modelling of the non-smooth dynamics is employed. A conception of the stability analysis of the periodic motions suited for this theoretical approach is presented. The frequency–response curves and force–response curves with stable and unstable branches are determined, and the interplay between various model parameters is investigated. The theoretical predictions related to the motion amplitude and the range of stability of the periodic steady-state response are verified via a series of numerical experiments and computation of Lyapunov exponents. Finally, the limitations and extensibility of the approach are discussed.
Contingency Planning and Early Crisis Management: Italy and the COVID-19 Pandemic
Authors: Mattei Paola , Vigevano Lorenzo 
Published: August 2021

AbstractThis study examines the level of preparedness exhibited through strategy, planning and organization to deal with the COVID-19 pandemic in Italy. A comparative analysis of four regions revealed that the implementation of pandemic plans was affected by multiple factors. For instance, some planning was outdated and insufficient to cope with the new threat posed by the pandemic; due to a decentralized health care system, there was confusion about whether regional or national decision-making was the coordinating actor; shortages in supplies and equipment such as masks, in some regions, were due to lack of implementation of existing pandemic plans. The study emphasizes the importance of a coordinated response to crises.
Problems of axiomatizing religion
Authors: Weingartner Paul 
Published: August 2021

AbstractThe paper discusses problems which arise in attempts to axiomatize parts of religion or religious belief systems. Besides those problems already investigated by Bochenski, like that of the propositional content or the meaning of religious discourse there are several further ones. This paper deals with the question whether full Classical Logic is suitable, whether one universe of discourse is sufficient, how to use definitions and analogous concepts and whether justifications satisfy credibility criteria.
Fragile Visions of the Social: Rethinking Solidarity with the Performance Piece Faust and the TV-series Skam
Authors: Schumann Claudia 
Published: August 2021

AbstractThe paper explores the portrayal of social relations among youth in the popular Norwegian TV-series Skam and places this analysis in relation to Anne Imhof’s award-winning performance piece Faust, which received the Golden Lion at the 2017 Venice Biennale for the German Pavilion. As expressions of how today’s youth experience social relations under the conditions of late capitalism, I examine the way in which the TV-series and the performance work respectively explore when and how ‘we’ is shaped. I argue that they provide particular insight into the limits and possibilities for the formation of relations of solidarity today.
Education for Critical Community and the Pedagogy of Asylum: Two Responses to the Crisis Of University Education
Authors: Koczanowicz Leszek , Włodarczyk Rafał 
Published: August 2021

AbstractThe current heated debate on the deteriorating status of the university raises a range of pertinent questions, including: What role can the humanities play in culture today in the face of the crisis of higher education? To answer this question, the authors begin by problematizing the relationship between culture, the humanities, and education. In the second part of the paper, they examine the changing role of the humanities in conjunction with the understandings of culture, and outline three salient ways in which culture is conceived of today. Subsequently, they focus on the loss of the dominant status that culture suffered when everyday life was discovered in modernity. In the third part, they argue that everyday life, or rather social representations of everyday life and its practices, are currently becoming the chief criterion for assessing culture, the humanities, and education. However, everyday life remains complex both in theoretical conceptualizations and in research observations. For example, everyday life harbors a range of risks and anxieties which are veiled by its own obviousness and reinforced by socialization. The authors conclude that, given this, everyday life in democratic societies calls for the work of understanding, support, affirmation, and criticism, in which the humanities can retain their superior status. In the fourth part, the authors discuss non-consensual democracy, critical community, and the pedagogy of asylum as the forms of organization and action that promote an auspicious interconnection of culture, the humanities, and education.
Epigenetic clock and methylation studies in cats
Authors: Raj Ken , Szladovits Balazs , Haghani Amin , Zoller Joseph A. , Li Caesar Z. , Black Pete , Maddox Dewey , Robeck Todd R. , Horvath Steve 
Published: August 2021

AbstractHuman DNA methylation profiles have been used successfully to develop highly accurate biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not immediately applicable to all species of the animal kingdom, the principles underpinning them appear to be conserved even in animals that are evolutionarily far removed from humans. This is exemplified by recent development of epigenetic clocks for mice and other mammalian species. Here, we describe epigenetic clocks for the domestic cat (Felis catus), based on methylation profiles of CpGs with flanking DNA sequences that are highly conserved between multiple mammalian species. Methylation levels of these CpGs are measured using a custom-designed Infinium array (HorvathMammalMethylChip40). From these, we present 3 epigenetic clocks for cats; of which, one applies only to blood samples from cats, while the remaining two dual-species human-cat clocks apply both to cats and humans. We demonstrate that these domestic cat clocks also lead to high age correlations in cheetahs, tigers, and lions. It is expected that these epigenetic clocks for cats possess the potential to be further developed for monitoring feline health as well as being used for identifying and validating anti-aging interventions.
Cytokine storm and histopathological findings in 60 cases of COVID-19-related death: from viral load research to immunohistochemical quantification of major players IL-1β, IL-6, IL-15 and TNF-α
Authors: Frisoni Paolo , Neri Margherita , D’Errico Stefano , Alfieri Letizia , Bonuccelli Diana , Cingolani Mariano , Di Paolo Marco , Gaudio Rosa Maria , Lestani Maurizio , Marti Matteo , Martelloni Massimo , Moreschi Carlo , Santurro Alessandro , Scopetti Matteo , Turriziani Ombretta , Zanon Martina , Scendoni Roberto , Frati Paola , Fineschi Vittorio 
Published: August 2021

AbstractThis study involves the histological analysis of samples taken during autopsies in cases of COVID-19 related death to evaluate the inflammatory cytokine response and the tissue localization of the virus in various organs. In all the selected cases, SARS-CoV-2 RT-PCR on swabs collected from the upper (nasopharynx and oropharynx) and/or the lower respiratory (trachea and primary bronchi) tracts were positive. Tissue localization of SARS-CoV-2 was detected using antibodies against the nucleoprotein and the spike protein. Overall, we tested the hypothesis that the overexpression of proinflammatory cytokines plays an important role in the development of COVID-19-associated pneumonia by estimating the expression of multiple cytokines (IL-1β, IL-6, IL-10, IL-15, TNF-α, and MCP-1), inflammatory cells (CD4, CD8, CD20, and CD45), and fibrinogen. Immunohistochemical staining showed that endothelial cells expressed IL-1β in lung samples obtained from the COVID-19 group (p < 0.001). Similarly, alveolar capillary endothelial cells showed strong and diffuse immunoreactivity for IL-6 and IL-15 in the COVID-19 group (p < 0.001). TNF-α showed a higher immunoreactivity in the COVID-19 group than in the control group (p < 0.001). CD8 + T cells where more numerous in the lung samples obtained from the COVID-19 group (p < 0.001). Current evidence suggests that a cytokine storm is the major cause of acute respiratory distress syndrome (ARDS) and multiple organ failure and is consistently linked with fatal outcomes.