bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous Erector Spinae Plane Block versus Intercostal Nerve Block in Patients Undergoing Video-assisted Thoracoscopic Surgery: A Pilot Randomized Controlled Trial
Authors: Horth Dillon , Sanh William , Moisiuk Peter , O’Hare Turlough , Shargall Yaron , Finley Christian , Hanna Waël , Agzarian John , Forero Mauricio , Davis Kim , Vanniyasingam Thuva , Thabane Lehana , Shanthanna Harsha 
Published: January 2021

Abstract
Background: The optimal analgesia method in video-assisted thoracoscopic surgery (VATS) remains controversial. Intercostal nerve blockade (ICNB) is limited by its duration of action. The erector spinae plane (ESP) block has the potential to provide satisfactory analgesia for VATS; however, the effectiveness of continuous ESP versus surgeon-performed ICNB has not been investigated. The objectives of this study were to establish feasibility of patient recruitment and follow-up before undertaking a fully powered randomized controlled trial (RCT); and, secondarily, to compare opioid usage, pain control, and sensory blockade.Methods: This feasibility RCT was undertaken at St Joseph’s Hospital, Hamilton, Ontario, Canada, and included 24 patients (>18 years) having elective VATS with at least one overnight stay. Exclusion criteria were patient refusal; body mass index >40 kg/m2; contraindications to neuraxial analgesia techniques as per the American Society of Regional Anesthesia and Pain guidelines; known allergy to local anesthetics; language or comprehension barriers; procedures with a higher chance of open surgery; and regular opioid use for ≥3 months preoperatively. Patients underwent either continuous ESP (n=12) or surgeon-performed ICNB (n=12). All patients received routine intraoperative anesthesia care and multimodal analgesia. Feasibility criteria were recruitment rate of two patients/week and full follow-up in all patients in-hospital. We compared opioid consumption, postoperative pain scores (0–10 numerical rating scale), adverse events, patient satisfaction, and distribution of sensory blockade as clinical outcomes (secondary).Results: Feasibility of primary outcomes was successfully demonstrated. Five patients had an epidural in anticipation of open surgery. Mean opioid consumption as equivalent morphine units, was less in the ESP group over the first 24 h (mean difference, 1.63 [95% CI –1.20 to 4.45]) and 48 h (mean difference, 2.34 [95% CI –1.93 to 6.61]). There were no differences in adverse effects.Conclusions: A fully powered RCT is feasible with modifications. Our results also suggest that continuous ESP is safe and can decrease opioid needs. However, it is important to consider procedures to improve compliance to protocol and adherence to assigned interventions.Trial registration: Clinicaltrials.gov identifier: NCT03176667. Registered June 5, 2017, https://clinicaltrials.gov/ct2/show/NCT03176667
Guidelines for the association of rural settlements (based on the materials of the Republic of Bashkortostan)
Authors: Атаева А.Г. 
Published: January 2021

В статье предлагаются методические рекомендации по объединению (укрупнению) сельских поселений, включающие в себя предложения не только по процессу преобразования и формированию органов местного самоуправления, но по подготовительным работам перед преобразованием. На основе оценки значений ключевых критериев возможности объединения предлагаются варианты укрупнения сельских поселений Республики Башкортостан.
In the article, the author offers methodological recommendations for the unification (enlargement) of rural settlements. Based on the assessment of the values of the key criteria for the possibility of unification, options for enlarging rural settlements of the Republic of Bashkortostan are proposed.
Principles of state budget management
Authors: Доброскок О.В. 
Published: January 2021

Принципы бюджетного менеджмента являются основой организации государственной системы управления финансовыми ресурсами на макроуровне, реализующей стратегические цели и текущие задачи бюджетной политики государства. Перечень принципов бюджетного менеджмента должен быть достаточным, научно обоснованным и иметь практическое применение в государственном менеджменте различного уровня. В статье рассмотрены принципы построения бюджетной системы Российской Федерации, принципы финансового менеджмента, принципы управления государственными и муниципальными финансами, общие принципы управленческих систем. В результате исследования проведен анализ принципов бюджетного менеджмента, предложен расширенный перечень принципов, в том числе учитывающий положения Конституции Российской Федерации, дано теоретическое обоснование предложенных принципов.
The principles of budget management lay down the foundations of the organization of the financial resources management state system at the macro level, which implements strategic goals and present-day problems of the state budget policy. The list of the budget management principles should be sufficient, scientifically substantiated and have practical application in public management at various levels. The article examines the principles of building the budget system of the Russian Federation, the principles of financial management, public and municipal finance management, as well as general principles of management systems. In the course of the study, the analysis of the budget management principles was carried out. As a result, an extended list of principles, in which the provisions of the Constitution of the Russian Federation are taken into consideration, was proposed. A theoretical justification of the proposed principles was given.
FOLFOXIRI versus FOLFOX or FOLFIRI with targeted therapy in patients with mutant BRAF metastatic colorectal cancer: A systematic review and meta-analysis
Authors: Fedyanin M. Yu. , Polyanskaya E. M. , Elsnukaeva H. H.-M. , Tryakin A. A. , Pokataev I. A. , Bulanov A. A. , Tjulandin S. A. 
Published: January 2021

Introduction. Based on the subgroup analysis of the TRIBE study FOLFOXIRI with bevacizumab is the recommended option for patients (pts) with mBRAF metastatic colorectal cancer (mCRC) in the 1st line. However, subgroup analysis of other studies showed conflicting results. Therefore, we performed systemic review and meta-analysis to compare efficacy FOLFOXIRI and doublets with targeted therapy in pts with mBRAF mCRC in terms of progression free survival (PFS), objective response rate (ORR) and overall survival (OS).Methods. We performed a search of all prospective randomizes studies in PubMed, ASCO and ESMO congresses for all years before May, 2020, compared FOLFOXIRI plus bevacizumab or anti-EGFR antibodies and FOLFOX or FOLFIRI with targeted agents at the 1st line with information of the BRAF status. Primary outcome was hazard ratio (HR) for PFS and 95% confidence interval (CI); secondary – HR for OS and odds ratio (OD) for ORR. Fixed effects were used for analysis. Meta-analysis was conducted by Review Manager Ver. 5.3.Results. We identified 6 trials (CHARTA, STEAM, TRIBE, TRIBE2, VISNU, METHEP2), which included 158 pts with mBRAF (FOLFOXIRI – 82 (52%) and doublets – 76 (48%). According to results of the meta-analysis there was a tendency for higher ORR in pts with FOLFOXIRI (OR 2.07, 95% CI 0.61–7.06; p = 0.24; I2 = 27%, p for heterogeneity 0.26; 3 trials). However we didn’t find any significant improvement in PFS (HR 0.89, 95% CI 0.64–1.23; p = 0.48; I2 = 0%, p for heterogeneity 0.63; 5 trials) or OS (HR 0.9, 95% CI 0.37–1.19; p = 0.048; I2 = 71%, p for heterogeneity 0.06; 2 trials) in the group of triplet.Conclusions. FOLFOXIRI with targeted therapy did not show significant improvement in the PFS and OS in pts with mBRAF compared with FOLFOX or FOLFIRI with targeted antibodies. A prospective randomized trial is needed to determine the optimal chemotherapy regimen at the 1st line for pts with mBRAF mCRC.
The dynamics of the incidence of breast cancer in the Moscow region (2011–2018)
Authors: Kogoniya L. M. , Astashov V. I. , Minakov S. N. 
Published: January 2021

Introduction. Breast cancer is a serious medical and social challenge and the statistics around the world look daunting.Relevance. The incidence of breast cancer is increasing in most countries and this may be due to a number of reasons. First of all, it should be noted the improvement of diagnostic methods, in particular, mass mammographic screening, which allows detecting neoplasms at early stages, before the onset of clinical symptoms. As for mortality rates, in recent years, world statistics show a downward trend in rates.Goal. To analyze the incidence and mortality rates of breast cancer (BC) in the Moscow Region (MO) for the period from 2011 to 2018. The study of indicators in one of the regions of Russia – MO – is of great importance for determining and predicting the true needs of the population in specialized medical care.The purpose of the study was to analyze the incidence of breast cancer (breast cancer) in the Moscow Region (MO) for a period of time from 2011 to 2018.Materials and methods. Some data of the territorial cancer registry of the Ministry of Defense of the Russian Federation on the diagnosis and treatment of patients with breast cancer were used, which will make it possible to determine the needs of this cohort of patients in specialized care.Results. From 2011 to 2018, 26755 new cases of breast cancer were diagnosed in the Moscow Region. The analysis of the comparative stratification in breast cancer in the medical district made it possible to obtain statistically significant differences indicating an increase in the incidence in the period from 2015–2018 in comparison with the period of 2011–2014. The presented data also indicate a trend towards a decrease in the one-year mortality rate over 8 years: from 6.33% in 2011 to 5.32% in 2018. For the period from 2011 to 2018 (8 years) there is an increase in the number of patients with breast cancer who have been in the medical center under dispensary supervision for 5 years or more.Conclusions. Analysis of the data obtained on the indicators of morbidity and mortality from malignant neoplasms is of great importance for determining the needs of the population in specialized medical care.
Experience of targeted therapy for ALK positive non-small cell lung cancer – a clinical case
Authors: Sultanbaev A. V. , Musin Sh. I. , Menshikov K. V. , Nasretdinov A. F. , Ibragimov B. A. , Nigmatullin A. G. , Ayupov R. T. , Izmailov A. A. , Sultanbaeva N. I. 
Published: January 2021

Lung cancer holds a leading position in the cancer mortality pattern worldwide. The emergence of knowledge about driver mutations heralded a new era in the targeted therapy for lung carcinomas. ALK translocation is identified in 5–7% of non-small cell lung cancer cases. ALK-positive lung adenocarcinomas are associated with specific clinical features, including no or light smoking history and younger age. Alectinib is a novel ALK inhibitor that has been granted a breakthrough therapy status by the FDA to accelerate approval as a second-line therapy after progression during crizotinib therapy.Here, the case of a patient with metastatic ALK-positive lung adenocarcinoma treated with alectinib has been discussed. Molecular genetic testing for driver mutations makes it possible to personalize approaches to anticancer drug therapy. At the same time, the custom-compounded targeted therapy is more often accompanied by significant objective responses and moderate symptoms of toxicity, which is relevant for patients in critical condition. The experience in using alectinib demonstrates the possibility of its long-term administration with high efficiency and a controlled safety profile.
Necessidades pessoais de Enfermeiros durante a pandemia da COVID-19 em Mato Grosso
Authors: Nascimento Vagner Ferreira do , Hattori Thalise Yuri , Terças-Trettel Ana Cláudia Pereira 
Published: January 2021

Objetivo: Identificar as necessidades pessoais de enfermeiros durante a pandemia da COVID-19 em Mato Grosso. Método: estudo exploratório e qualitativo, realizado em abril de 2020, com enfermeiros do estado de Mato Grosso. Utilizou-se o discurso do sujeito coletivo e a Teoria das Necessidades Humanas de Maslow. Resultados: Os participantes apresentaram necessidades intermediárias (segurança e sociais) quanto as categorias da teoria de Maslow. Em relação aos discursos foram obtidas quatro ideias centrais: autocuidado, necessidade de afeto, compreensão do distanciamento e prejuízos na relação conjugal. Conclusões: As necessidades pessoais dos enfermeiros refletem o impacto das medidas protetivas recomendadas durante a pandemia da COVID-19 tanto no contexto laboral como familiar.Descritores: Pandemias; Coronavirus; Pessoal de Saúde; Carência Psicossocial.PERSONAL NEEDS OF NURSES DURING THE COVID-19 PANDEMICIN MATO GROSSOObjective: To identify the personal needs of nurses during the COVID-19 pandemic in Mato Grosso. Method: exploratory and qualitative study, conducted in April 2020, with Nurses from the state of Mato Grosso. The collective subject discourse and Maslow Theory of Human Needs were used. Results: The participants presented intermediate needs (security and social) regarding the categories of Maslow theory. Regarding the speeches, four central ideas were obtained: self-care, need for affection, understanding of distance and losses in the marital relationship. Conclusions: nurse personal needs reflect the impact of the protective measures recommended during the COVID-19 pandemic in both the work and family context.Descriptors: Pandemics; Coronavirus; Health Personnel; Psychosocial Deprivation.NECESIDADES PERSONALES DE ENFERMERAS DURANTE LA PANDEMIA DE COVID-19 EM MATO GROSSOObjetivo: identificar las necesidades personales de las enfermeras durante la pandemia de COVID-19 en Mato Grosso. Método: estudio exploratorio y cualitativo, realizado en abril de 2020, con enfermeras del estado de Mato Grosso. Se utilizó el discurso del sujeto colectivo y la Teoría de las Necesidades Humanas de Maslow. Resultados: Los participantes presentaron necesidades intermedias (seguridad y sociales) en relación con las categorías de la teoría de Maslow. Con respecto a los discursos, se obtuvieron cuatro ideas centrales: autocuidado, necesidad de afecto, comprensión de la distancia y pérdidas en la relación matrimonial. Conclusiones: Las necesidades personales de las enfermeras reflejan el impacto de las medidas de protección recomendadas durante la pandemia de COVID-19, tanto en el contexto laboral como familiar.Descriptores: Pandemias; Coronavirus; Personal de Salud; Carencia Psicosocial.
Characterization and Expression Analysis of Resistance Gene Analogues in Elite Sugarcane Genotypes
Authors: Parvaiz Aqsa , Mustafa Ghulam , Khan Muhammad Sarwar , Ali Muhammad Amjad 
Published: January 2021

Background:
Resistance Gene Analogues (RGAs) are an important source of disease resistance
in crop plants and have been extensively studied for their identification, tagging and mapping
of Quantitative Trait Loci (QTLs). Tracking these RGAs in sugarcane can be of great help for
the selection and screening of disease resistant clones.

Objective:
In the present study expression of different Resistance Gene Analogues (RGAs) was assessed
in indigenous elite sugarcane genotypes which include resistant, highly resistant, susceptible
and highly susceptible to disease infestation.

Methods:
Total cellular DNA and RNA were isolated from fourteen indigenous elite sugarcane
genotypes. PCR, semi-quantitative RT PCR and real time qPCR analyses were performed. The resultant
amplicons were sequence characterized, chromosomal localization and phylogenetic analysis
were performed.

Results:
All of the 15 RGA primers resulted in amplification of single or multiple fragments from
genomic DNA whereas only five RGA primers resulted in amplification from cDNA. Sequence
characterization of amplified fragments revealed 86-99% similarity with disease resistance proteins
indicating their potential role in disease resistance response. Phylogenetic analysis also validated these
findings. Further, expression of RGA-012, RGA-087, RGA-118, RGA-533 and RGA-542 appeared
to be upregulated and down regulated in disease resistant and susceptible genotypes, respectively,
after inoculation with Colletotrichum falcatum.

Conclusion:
RGAs are present in most of our indigenous genotypes. Anyhow, differential expression
of five RGAs indicated that they have some critical role in disease resistance. So, the retrieved
results can not only be employed to devise molecular markers for the screening of disease resistant
genotypes but can also be used to develop disease resistant plants through transgenic technology.
Rapid Profiling of the Marker Components in Artemisia annua L. and their Metabolites in Rats Using an Improved Liquid Chromatography-tandem Highresolution Mass Spectrometry-based Technology
Authors: Wang Xin , Cai Tianyu , Xie Yuewu , Chen Xiaoyue , Yang Aijuan , Xing Jie 
Published: January 2021

Background:
As parasite resistance to the main artemisinin drugs has emerged in Southern Asia, the
traditional herb Artemisia annua L. (AAL) from which artemisinin (QHS) isolated was found to overcome resistance
to QHS. However the component and metabolite profiles of AAL remain unclear.

Objectives:
In this study, component profiling of marker compounds in AAL (amorphane sesquiterpene lactones and flavonoids) was performed, and their subsequent metabolism was investigated in rats.

Methods:
For efficient component classification and structural characterization, an improved liquid chromatography-
tandem high-resolution mass spectrometry (HRMS)-based analytical strategy was applied, i.e., background
subtraction (BS) followed by ring-double-bond (RDB) filter in tandem with repeated BS processing.
Structures of detected components/metabolites were characterized based on integrated information including
their HRMSn patterns, RDB values, the established component/metabolite network, the biosynthesis pathways
of AAL, and/or NMR data.

Results:
A total of 38 amorphane sesquiterpene lactones and 35 flavonoids were found in AAL as prototype
compounds, among which 26 components were previously undescribed. Major compounds were identified by
comparing them with reference standards. Among 73 AAL prototypes administered, 38 were absorbed in the
circulation as the prototype. Moreover, 20 metabolites of amorphane sesquiterpene lactones and 10 metabolites
of flavonoids were detected in rats. The major metabolic pathways included oxidation, methylation, glucuronidation
and sulfation.

Conclusion:
The component and metabolite network were established for marker components in AAL, which
will be valuable to understand the synergistic antimalarial potency of QHS in A. annua L. The analytical strategy
can also be applied to other herbal medicines.
Pulmonary Rehabilitation in COVID-19: The Contribution of other Chronic Lung Syndromes for the Intervention of a Novel Disease
Authors: Benavides-Córdoba Vicente , Guerrero-Jaramillo Diana , Betancourt-Peña Jhonatan 
Published: January 2021

Abstract::
COVID-19 has spread throughout the world causing a significant number of cases of
pneumonia and SARS. Patients with COVID-19 may also have other cardiovascular, respiratory,
and neuromuscular disorders. These multisystemic complications present the need for comprehensive
interventions focused on improving symptoms, functional capacity, and quality of life. Pulmonary
rehabilitation has the potential to offer some of these benefits. However, the evidence related
to specific aspects of pulmonary rehabilitation evaluation and intervention in COVID19 is limited.
We have learned from experiences with other types of chronic lung diseases that have used pulmonary
rehabilitation successfully. While the evidence of rehabilitation emerges in COVID-19, it is
necessary to establish some initial recommendations, prepared according to the sequelae found until
now.
The Prospect for Type 2 Diabetes Mellitus Combined with Exercise and Synbiotics: A Perspective
Authors: Dewi Luthfia , Rosidi Ali , Noer Etika Ratna , Ayuningtyas Annisa 
Published: January 2021

:
Change in gut microbiome diversity (the so-called dysbiosis) is correlated with insulin
resistance conditions. Exercise is typically the first management for people with type 2 diabetes
mellitus (T2DM), which is generally well-known for improving glucose regulation. The new prebiotics
and probiotics, like synbiotics, designed to target specific diseases, require additional studies.
While the effectiveness of exercise combined with synbiotics seems promising, this review discusses
these agents’ possibility of increasing the gut microbiota’s diversity. Therefore, they could enhance
short-chain fatty acids (SCFA). In particular, the synbiotic interaction on gut microbiota, the
exercise mechanism in improving gut microbiota, and the prospect of the synergistic effect of the
combination of synbiotic and exercise to improve insulin sensitivity are addressed.
Loneliness and Social Isolation: Determinants of Cardiovascular Outcomes
Authors: Sharma Tanya , Padala Prasad R. , Mehta Jawahar L. 
Published: January 2021

:
One in three Americans report experiencing loneliness in everyday life, a number that has grown exponentially over the last few decades. As we respond to the SARS-COV2 pandemic with quarantine and social distancing, social isolation and feelings of loneliness are increasing among people of all ages. This presents as an opportune time to recognize the public health impact of these important psychosocial determinants. Loneliness and social isolation are associated with higher incidence of CVD, higher healthcare utilization and worse outcomes even after controlling for conventional risk factors of CVD. In this review, we discuss loneliness and social isolation as determinants of cardiovascular outcomes, the pathophysiology of this association, and its implications in clinical practice. We discuss some of the shortcomings in assessment of loneliness and social isolation while identifying most commonly used rating scales for the same. Finally, we suggest modifications to interventions for loneliness and social isolation during the COVID-19 pandemic.