bluuebunny/crossref_metadata_2025_split huggingface dataset:
Women Veterans’ Experiences with Integrated, Biopsychosocial Pain Care: A Qualitative Study
Authors: Nicosia Francesca M , Gibson Carolyn J , Purcell Natalie , Zamora Kara , Tighe Jennifer , Seal Karen H 
Published: January 2021

Abstract

Objectives
Biopsychosocial, integrated pain care models are increasingly implemented in the Veterans Health Administration to improve chronic pain care and reduce opioid-related risks, but little is known about how well these models address women veterans’ needs.

Design
Qualitative, interview-based study.

Setting
San Francisco VA Health Care System Integrated Pain Team (IPT), an interdisciplinary team that provides short-term, personalized chronic pain care emphasizing functional goals and active self-management.

Subjects
Women with chronic pain who completed ≥3 IPT sessions.

Methods
Semistructured phone interviews focused on overall experience with IPT, perceived effectiveness of IPT care, pain care preferences, and suggested changes for improving gender-sensitive pain care. We used a rapid approach to qualitative thematic analysis to analyze interviews.

Results
Fourteen women veterans (mean age 51 years; range 33–67 years) completed interviews. Interviews revealed several factors impacting women veterans’ experiences: 1) an overall preference for receiving both primary and IPT care in gender-specific settings, 2) varying levels of confidence that IPT could adequately address gender-specific pain issues, 3) barriers to participating in pain groups, and 4) barriers to IPT self-management recommendations due to caregiving responsibilities.

Conclusions
Women veterans reported varied experiences with IPT. Recommendations to improve gender-sensitive pain care include increased provider training; increased knowledge of and sensitivity to women’s health concerns; and improved accommodations for prior trauma, family and work obligations, and geographic barriers. To better meet the needs of women veterans with chronic pain, integrated pain care models must be informed by an understanding of gender-specific needs, challenges, and preferences.
Pain Management Evaluation in Maintenance Hemodialysis Patients
Authors: Dreiher Jacob , Fleishman Tatiana Talya , Shvartzman Pesach 
Published: January 2021

AbstractContextPain is a common complaint in maintenance hemodialysis (MHD) patients, and it is often inadequately assessed and inappropriately treated.ObjectivesThe study goal was to preliminarily evaluate pain management in MHD patients.MethodsThe study was a cross-sectional study conducted in 2013–2015. A sample of 277 MHD patients who reported pain within the last 24 hours from five hospital hemodialysis units in Israel were interviewed and evaluated. Study tools included the Brief Pain Inventory, the Pain Management Index (PMI), demographic and clinical characteristics. Pharmacy computerized data were reviewed to identify the type of analgesics used.ResultsMean pain level was 7.2 ± 2.2 (median: 8). Pain level was mild in 17 (6.1%), moderate in 120 (43.3%) and severe in 140 (50.5%) of patients. Only 185 participants (66.8%) were treated with analgesics during the year prior to the interview. Of these, 99 (53.5%) received opioids. Using the PMI to preliminarily assess the appropriateness of the treatment, 214 (77.3%) of patients with pain in the last 24 hours were undertreated, and 52 patients (18.8%) were appropriately treated. In a multivariable analysis, factors associated with inappropriate treatment were severe pain intensity and a higher Functional Independent Measure (FIM). A lower FIM was associated with opioid use in a multivariable analysis.ConclusionsAccording to the PMI, most dialysis patients were found to be inappropriately treated. About one third received opioids, but even among them, inappropriate treatment was common. Pain management in MHD patients needs to be improved.
Electronic Delivery of Pain Education for Chronic Overlapping Pain Conditions: A Prospective Cohort Study
Authors: McKernan Lindsey C , Crofford Leslie J , Kim Ahra , Vandekar Simon N , Reynolds William S , Hansen Kathryn A , Clauw Daniel J , Williams David A 
Published: January 2021

Abstract

Objective
To examine the impact of educational materials for chronic overlapping pain conditions (COPCs), the feasibility of delivering materials online, and to explore its impact on self-reported self-management applications at 3-month follow-up.

Design
Prospective cohort study

Setting
Online

Subjects
Individuals from a university-wide active research repository with ≥1 coded diagnostic COPC by ICD-9/10 in the medical record.

Methods
We determined the number of COPCs per participant as indicated by diagnostic codes in the medical record. Consenting participants completed self-report questionnaires and read educational materials. We assessed content awareness and knowledge pre- and post-exposure to education. Comprehension was assessed via embedded questions in reading materials in real time. Participants then completed assessments regarding concept retention, self-management engagement, and pain-related symptoms at 3-months.

Results
N = 216 individuals enrolled, with 181 (84%) completing both timepoints. Results indicated that participants understood materials. Knowledge and understanding of COPCs increased significantly after education and was retained at 3-months. Patient characteristics suggested the number of diagnosed COPCs was inversely related to age. Symptoms or self-management application did not change significantly over the 3-month period.

Conclusions
The educational materials facilitated teaching of key pain concepts in self-management programs, which translated easily into an electronic format. Education alone may not elicit self-management engagement or symptom reduction in this population; however, conclusions are limited by the study’s uncontrolled design. Education is likely an important and meaningful first step in comprehensive COPC self-management.
The 4-Element Movement System Model to Guide Physical Therapist Education, Practice, and Movement-Related Research
Authors: McClure Philip , Tevald Michael , Zarzycki Ryan , Kantak Shailesh , Malloy Philip , Day Kristin , Shah Kshamata , Miller Amy , Mangione Kathleen 
Published: January 2021

Abstract
The movement system has been adopted as the key identity for the physical therapy profession, and recognition of physical therapists’ primary expertise in managing movement dysfunction is an important achievement. However, existing movement system models seem inadequate for guiding education, practice, or research. Lack of a clear, broadly applicable model may hamper progress in physical therapists actually adopting this identity. We propose a model composed of 4 primary elements essential to all movement: motion, force, energy, and control. Although these elements overlap and interact, they can each be examined and tested with some degree of specificity. The proposed 4-element model incorporates specific guidance for visual, qualitative assessment of movement during functional tasks that can be used to develop hypotheses about movement dysfunction and serve as a precursor to more quantitative tests and measures. Human movement always occurs within an environmental context and is affected by personal factors, and these concepts are represented within the model. The proposed scheme is consistent with other widely used models within the profession, such as the International Classification of Functioning, Disability and Health and the Patient Management Model. We demonstrate with multiple examples how the model can be applied to a broad spectrum of patients across the lifespan with musculoskeletal, neurologic, and cardiopulmonary disorders.
Predictive value of anti-CarP and anti-PAD3 antibodies alone or in combination with RF and ACPA for the severity of rheumatoid arthritis
Authors: Lamacchia Celine , Courvoisier Delphine S , Jarlborg Matthias , Bas Sylvette , Roux-Lombard Pascale , Möller Burkhard , Ciurea Adrian , Finckh Axel , Bentow Chelsea , Martinez-Prat Laura , Mahler Michael , Gabay Cem , Nissen Michael J ,   the SCQM Rheumatologists
Published: January 2021

Abstract

Objectives
The objective of this study was to analyse the predictive value of anti-carbamylated protein (anti-CarP) and anti-peptidyl-arginine deiminase type-3 (anti-PAD3) antibodies, alone or in combination with RF and ACPA, to identify patients at high risk of developing severe RA outcomes.

Methods
Patients within the Swiss Clinical Quality Management registry with a biobank sample were tested for RF, ACPA, anti-CarP, and anti-PAD3 antibodies. We examined the association of each autoantibody with DAS28, HAQ and radiographic damage (Ratingen) at baseline and longitudinally.

Results
Analyses included 851 established RA patients and 516 disease controls [axial spondyloarthritis (axSpA = 320) and PsA (196)]. Anti-CarP and anti-PAD3 antibodies were, respectively, present in 22.4% and 10.7% of the whole RA population, and in 13.2% and 3.8% of the RF and ACPA double seronegative patients. At baseline, RA patients with anti-PAD3 had higher DAS28 (4.2 vs 3.7; P= 0.005) and significantly more radiographic damage (14.9 vs 8.8; P= 0.02) than anti-PAD3-negative patients. In the ACPA-negative subgroup, baseline Ratingen scores were significantly higher in anti-PAD3-positive patients (P= 0.01). The combination of anti-PAD3, RF IgM, and ACPA was associated with significantly higher baseline radiographic scores than the double seropositive group (P= 0.04). The presence of any two of the previous autoantibodies was associated with significantly greater radiographic progression over 10 years than if all were absent (P= 0.02). There were no differences in RA outcome measures with regards to anti-CarP.

Conclusions
Anti-PAD3 antibodies are associated with higher disease activity and joint damage scores in RA patients.
Association between current medication use and progression of radiographic knee osteoarthritis: data from the osteoarthritis initiative
Authors: Perry Thomas A , Wang Xia , Nevitt Michael , Abdelshaheed Christina , Arden Nigel , Hunter David J 
Published: January 2021

Abstract

Objective
Use of specific medications may accelerate the progression of radiographic knee OA (RKOA). Our aim was to examine the effect of medication use on the progression of RKOA.

Methods
We used longitudinal data from the Osteoarthritis Initiative (OAI), an observational study of risk factors for knee OA. At baseline, we selected participants with RKOA (Kellgren–Lawrence grade ≥2) and excluded those with a history of knee-related injury/surgery and other musculoskeletal disorders. Current medication use (use/non-use in the previous 30 days) and radiographic medial minimum joint space width (mJSW) data were available at baseline and annually up to 96 months follow-up. We used random effects, panel regression to assess the association between current medication use (non-users as reference group) and change in mJSW.

Results
Of 2054 eligible participants, 2003 participants with baseline mJSW data were included [55.7% female, mean age 63.3 (s.d. 8.98) years]. Of seven medication classes, at baseline NSAIDs were the most frequently used analgesia (14.7%), anti-histamine (10.4%) use was frequent and the following comorbidity medications were used most frequently: statins (27.4%), anti-hypertensives (up to 15.0%), anti-depressant/anxiolytics/psychotropics (14.0%), osteoporosis-related medication (10.9%) and diabetes-related medication (6.9%). Compared with current non-users, current use of NSAIDs was associated with a loss of mJSW (b = −0.042, 95% CI −0.08, −0.0004). No other associations were observed.

Conclusions
In current users of NSAIDs, mJSW loss was increased compared with current non-users in participants with RKOA. Clinical trials are required to assess the potential disease-modifying effects of these medications.
RNAi-mediated repression of dormancy-related genes results in evergrowing apple trees
Authors: Wu Rongmei , Cooney Janine , Tomes Sumathi , Rebstock Ria , Karunairetnam Sakuntala , Allan Andrew C , Macknight Richard C , Varkonyi-Gasic Erika 
Published: January 2021

Abstract
DORMANCY-ASSOCIATED MADS-box (DAM) and SHORT VEGETATIVE PHASE (SVP) genes have been implicated in the regulation of winter dormancy in perennials. Ectopic expression of apple (Malus × domestica Borkh. ‘Royal Gala’) DAM and SVP genes delays budbreak and constrains lateral shoot outgrowth. In this study, we used RNA interference (RNAi) to simultaneously target all apple DAM and SVP genes in order to study their role and mode of action in the regulation of bud dormancy, budbreak and flowering. A synthetic construct carrying a hairpin fragment assembled from sequences specific to coding regions of three DAM and two SVP genes was used to generate transgenic lines. Reduced expression of DAM/SVP genes resulted in delayed leaf senescence and abscission in autumn, failure to enter bud dormancy in winter and continual growth of new leaves regardless of the season for over 3 years. Precocious flowering but normal flower morphology, fertility and fruit development were observed. The non-dormant phenotype was associated with modified phytohormone composition. The content of gibberellins (GAs) and jasmonates (JAs) was significantly increased in terminal buds of RNAi lines compared with wildtype plants, accompanied by elevated expression of the key GA biosynthesis pathway gene GIBBERELLIN 20 OXIDASE-2 (MdGA20ox-2) along with the FLOWERING LOCUS T gene MdFT2. The key mediator of plasmodesmatal closure, MdCALLOSE SYNTHASE 1 (MdCALS1), was repressed in RNAi lines. This study provides functional evidence for the role of DAM/SVP genes in vegetative phenology of apple and paves the way for production of low-chill varieties suitable for growth in warming climates.
High-Quality Genome Resource of the Pathogen of Botryosphaeria dothidea Causing Kiwifruit Soft Rot
Authors: Liang Kuan , Lan Jianbin , Wang Baoquan , Liu Yuanyuan , Lu Qi , Liu Pu 
Published: January 2021

Kiwifruit soft rot caused by the fungal pathogen Botryosphaeria dothidea is a serious disease in kiwifruit-growing regions worldwide. In this study, we reported the high-quality genome sequence of the highly virulent B. dothidea strain PTZ1 using PacBio Sequel techniques. In total, 100.87 million clean reads with mean read length of 9,871 bp were obtained. De novo assembly resulted in 28 contigs with a total size of 44.45 Mb. The GC content of the genome was 54.59%. Furthermore, genes related to specific virulence of the strain were identified, including 259 fungal cytochrome P450s, 550 carbohydrate-active enzymes, 860 secretory proteins, and 1,182 pathogen–host interactions related proteins. The genome is a useful resource to serve as a reference to facilitate the analysis of B. dothidea isolates and comparative genomic studies of the necrotroph pathogens. [Formula: see text] Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Multi-omics Comparison Reveals Landscape of Citrus limon and Citrus sinensis Response to ‘Candidatus Liberibacter asiaticus’
Authors: Chin Elizabeth L. , Ramsey John , Saha Surya , Mishchuk Darya , Chavez Juan , Howe Kevin , Zhong Xuefei , Flores-Gonzalez Mirella , Mitrovic Elizabeth , Polek MaryLou , Godfrey Kris , Mueller Lukas A. , Bruce James , Heck Michelle , Slupsky Carolyn M. 
Published: January 2021

Comparison of the metabolic changes prior to symptom development upon infection with Candidatus Liberibacter asiaticus (CLas), the bacterium associated with citrus greening disease, between citrus hosts with different tolerances is lacking. The objective of this study was to compare the early response of Lisbon lemon (Citrus limon) and Washington navel orange (Citrus sinensis [L.] Osbeck), two citrus species commercially important to California, to CLas through graft inoculation. Here, we compare the transcriptome, proteome, and metabolome response, using RNA sequencing, liquid chromatography tandem mass spectrometry, and 1H nuclear magnetic resonance, respectively, from our two recently published studies examining the response of the lemon and navel oranges separately, and introduce new micronutrient data from inductively coupled plasma mass spectrometry analysis, focusing on lemons at 10 and 14 weeks postgrafting (wpg), and navels at 8 and 18 wpg, prior to symptom development. Several micronutrients accumulated in presymptomatic infected lemons compared with controls, whereas little change was observed in the navels. Photosynthesis proteins were substantially altered by CLas infection in navels, with fewer changes observed in lemons. The metabolome differed between control and infected navels throughout infection, although differences between control and infected lemons were identified only after symptom expression. Taken together, these findings highlight differences in response to CLas between two varieties with differing tolerances. [Formula: see text] Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Stochastic resonance in deformable potential with time-delayed feedback
Authors: Wadop Ngouongo Y. J. , Djolieu Funaye M. , Djuidjé Kenmoé G. , Kofané T. C. 
Published: January 2021

This paper reports the stochastic resonance (SR) phenomenon with memory effects for a Brownian particle in a potential whose shape is subjected to deformation. We model the deformation in the system by the Remoissenet–Peyrard potential and the memory effects by the time-delayed feedback. The question of the possible influence of time-delayed feedback on the occurrence of SR is then of our interest. We examine numerically the effect of feedback strength as well as time delay on SR phenomenon in terms of hysteresis loop area. It is found that time-delayed feedback has a significant effect on SR and can induce double resonances in the system. We show that the properties of SR are varying, depending on interdependence between feedback strength, time delay and shape parameter.
This article is part of the theme issue ‘Vibrational and stochastic resonance in driven nonlinear systems (part 1)’.
Study of vibrational resonance in nonlinear signal processing
Authors: Pan Yan , Duan Fabing , Chapeau-Blondeau François , Xu Liyan , Abbott Derek 
Published: January 2021

Vibrational resonance (VR) intentionally applies high-frequency periodic vibrations to a nonlinear system, in order to obtain enhanced efficiency for a number of information processing tasks. Note that VR is analogous to stochastic resonance where enhanced processing is sought via purposeful addition of a random noise instead of deterministic high-frequency vibrations. Comparatively, due to its ease of implementation, VR provides a valuable approach for nonlinear signal processing, through detailed modalities that are still under investigation. In this paper, VR is investigated in arrays of nonlinear processing devices, where a range of high-frequency sinusoidal vibrations of the same amplitude at different frequencies are injected and shown capable of enhancing the efficiency for estimating unknown signal parameters or for detecting weak signals in noise. In addition, it is observed that high-frequency vibrations with differing frequencies can be considered, at the sampling times, as independent random variables. This property allows us here to develop a probabilistic analysis—much like in stochastic resonance—and to obtain a theoretical basis for the VR effect and its optimization for signal processing. These results provide additional insight for controlling the capabilities of VR for nonlinear signal processing.
This article is part of the theme issue ‘Vibrational and stochastic resonance in driven nonlinear systems (part 1)’.
Inhibitors of ERp44, PDIA1, and AGR2 induce disulfide-mediated oligomerization of Death Receptors 4 and 5 and cancer cell death
Authors: Law Mary E. , Yaaghubi Elham , Ghilardi Amanda F. , Davis Bradley J. , Ferreira Renan B. , Koh Jin , Chen Sixue , DePeter Sadie F. , Schilson Christopher M. , Chiang Chi-Wu , Heldermon Coy D. , Nørgaard Peter , Castellano Ronald K. , Law Brian K. 
Published: January 2021

AbstractBreast cancer mortality remains unacceptably high, indicating a need for safer and more effective therapeutic agents. Disulfide bond Disrupting Agents (DDAs) were previously identified as a novel class of anticancer compounds that selectively kill cancers that overexpress the Epidermal Growth Factor Receptor (EGFR) or its family member HER2. DDAs kill EGFR+ and HER2+ cancer cells via the parallel downregulation of EGFR, HER2, and HER3 and activation/oligomerization of Death Receptors 4 and 5 (DR4/5). However, the mechanisms by which DDAs mediate these effects are unknown. Affinity purification analyses employing biotinylated-DDAs reveal that the Protein Disulfide Isomerase (PDI) family members AGR2, PDIA1, and ERp44 are DDA target proteins. Further analyses demonstrate that shRNA-mediated knockdown of AGR2 and ERp44, or expression of ERp44 mutants, enhance basal and DDA-induced DR5 oligomerization. DDA treatment of breast cancer cells disrupts PDIA1 and ERp44 mixed disulfide bonds with their client proteins. Together, the results herein reveal DDAs as the first small molecule, active site inhibitors of AGR2 and ERp44, and demonstrate roles for AGR2 and ERp44 in regulating the activity, stability, and localization of DR4 and DR5, and activation of Caspase 8.
SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy
Authors: Lee Tzu-Han , Wu David , Guzy Robert , Schoettler Nathan , Adegunsoye Ayodeji , Mueller Jeffrey , Hussein Aliya , Sperling Anne , Mutlu Gökhan M. , Fang Yun 
Published: January 2021

ABSTRACTAcute respiratory distress syndrome (ARDS) occurred in ~12% of hospitalized COVID-19 patients in a recent New York City cohort. Pulmonary endothelial dysfunction, characterized by increased expression of inflammatory genes and increased monolayer permeability, is a major component of ARDS. Vascular leak results in parenchymal accumulation of leukocytes, protein, and extravascular water, leading to pulmonary edema, ischemia, and activation of coagulation associated with COVID-19. Endothelial inflammation further contributes to uncontrolled cytokine storm in ARDS. We have recently demonstrated that Krüppel-like factor 2 (KLF2), a transcription factor which promotes endothelial quiescence and monolayer integrity, is significantly reduced in experimental models of ARDS. Lung inflammation and high-tidal volume ventilation result in reduced KLF2, leading to pulmonary endothelial dysfunction and acute lung injury. Mechanistically, we found that KLF2 is a potent transcriptional activator of Rap guanine nucleotide exchange factor 3 (RAPGEF3) which orchestrates and maintains vascular integrity. Moreover, KLF2 regulates multiple genome-wide association study (GWAS)-implicated ARDS genes. Whether lung KLF2 is regulated by SARS-CoV-2 infection is unknown. Here we report that endothelial KLF2 is significantly reduced in human lung autopsies from COVID-19 patients, which supports that ARDS due to SARS-CoV-2 is a vascular phenotype possibly attributed to KLF2 down-regulation. We provide additional data demonstrating that KLF2 is down-regulated in SARS-CoV infection in mice.