bluuebunny/crossref_metadata_2025_split huggingface dataset:
Growth arrest and DNA damage-inducible proteins (GADD45) in psoriasis
Authors: Rodríguez-Jiménez Pedro , Fernández-Messina Lola , Ovejero-Benito María C. , Chicharro Pablo , Vera-Tomé Paula , Vara Alicia , Cibrian Danay , Martínez-Fleta Pedro , Jiménez-Fernández María , Sánchez-García Inés , Llamas-Velasco Mar , Abad-Santos Francisco , Sánchez-Madrid Francisco , Dauden Esteban , de la Fuente Hortensia 
Published: July 2021

AbstractThe interplay between T cells, dendritic cells and keratinocytes is crucial for the development and maintenance of inflammation in psoriasis. GADD45 proteins mediate DNA repair in different cells including keratinocytes. In the immune system, GADD45a and GADD45b regulate the function and activation of both T lymphocytes and dendritic cells and GADD45a links DNA repair and epigenetic regulation through its demethylase activity. Here, we analyzed the expression of GADD45a and GADD45b in the skin, dendritic cells and circulating T cells in a cohort of psoriasis patients and their regulation by inflammatory signals. Thirty patients (17 male/13 female) with plaque psoriasis and 15 controls subjects (7 male/8 female), were enrolled. Psoriasis patients exhibited a lower expression of GADD45a at the epidermis but a higher expression in dermal infiltrating T cells in lesional skin. The expression of GADD45a and GADD45b was also higher in peripheral T cells from psoriasis patients, although no differences were observed in p38 activation. The expression and methylation state of the GADD45a target UCHL1 were evaluated, revealing a hypermethylation of its promoter in lesional skin compared to controls. Furthermore, reduced levels of GADD45a correlated with a lower expression UCHL1 in lesional skin. We propose that the demethylase function of GADD45a may account for its pleiotropic effects, and the complex and heterogeneous pattern of expression observed in psoriatic disease.
Novel competition test for food rewards reveals stable dominance status in adult male rats
Authors: Costa Diana F. , Moita Marta A. , Márquez Cristina 
Published: July 2021

AbstractSocial hierarchy is a potent modulator of behavior, that is typically established through overt agonistic interactions between individuals in the group. Once established, social ranks are maintained through subtler interactions allowing the redirection of energy away from agonistic interactions towards other needs. The available tasks for assessing social rank in rats allow the study of the mechanisms by which social hierarches are formed in early phases but fail to assess the maintenance of established hierarchies between stable pairs of animals, which might rely on distinct neurobiological mechanisms. Here we present and validate a novel trial-based dominancy assay, the modified Food Competition test, where established social hierarchies can be identified in the home cage of non-food deprived pairs of male rats. In this task, we introduce a small conflict in the home cage, where access to a new feeder containing palatable pellets can only be gained by one animal at a time. We found that this subtle conflict triggered asymmetric social interactions and resulted in higher consumption of food by one of the animals in the pair, which reliably predicted hierarchy in other tests. Our findings reveal stable dominance status in pair-housed rats and provide a novel tool for the evaluation of established social hierarchies, the modified Food Competition test, that is robust and easy to implement.
Mitochondrial energetics with transmembrane electrostatically localized protons: do we have a thermotrophic feature?
Authors: Lee James Weifu 
Published: July 2021

AbstractTransmembrane electrostatically localized protons (TELP) theory has been recently recognized as an important addition over the classic Mitchell’s chemiosmosis; thus, the proton motive force (pmf) is largely contributed from TELP near the membrane. As an extension to this theory, a novel phenomenon of mitochondrial thermotrophic function is now characterized by biophysical analyses of pmf in relation to the TELP concentrations at the liquid-membrane interface. This leads to the conclusion that the oxidative phosphorylation also utilizes environmental heat energy associated with the thermal kinetic energy (kBT) of TELP in mitochondria. The local pmf is now calculated to be in a range from 300 to 340 mV while the classic pmf (which underestimates the total pmf) is in a range from 60 to 210 mV in relation to a range of membrane potentials from 50 to 200 mV. Depending on TELP concentrations in mitochondria, this thermotrophic function raises pmf significantly by a factor of 2.6 to sixfold over the classic pmf. Therefore, mitochondria are capable of effectively utilizing the environmental heat energy with TELP for the synthesis of ATP, i.e., it can lock heat energy into the chemical form of energy for cellular functions.
Multi-view convolutional neural networks for automated ocular structure and tumor segmentation in retinoblastoma
Authors: Strijbis Victor I. J. , de Bloeme Christiaan M. , Jansen Robin W. , Kebiri Hamza , Nguyen Huu-Giao , de Jong Marcus C. , Moll Annette C. , Bach-Cuadra Merixtell , de Graaf Pim , Steenwijk Martijn D. 
Published: July 2021

AbstractIn retinoblastoma, accurate segmentation of ocular structure and tumor tissue is important when working towards personalized treatment. This retrospective study serves to evaluate the performance of multi-view convolutional neural networks (MV-CNNs) for automated eye and tumor segmentation on MRI in retinoblastoma patients. Forty retinoblastoma and 20 healthy-eyes from 30 patients were included in a train/test (N = 29 retinoblastoma-, 17 healthy-eyes) and independent validation (N = 11 retinoblastoma-, 3 healthy-eyes) set. Imaging was done using 3.0 T Fast Imaging Employing Steady-state Acquisition (FIESTA), T2-weighted and contrast-enhanced T1-weighted sequences. Sclera, vitreous humour, lens, retinal detachment and tumor were manually delineated on FIESTA images to serve as a reference standard. Volumetric and spatial performance were assessed by calculating intra-class correlation (ICC) and dice similarity coefficient (DSC). Additionally, the effects of multi-scale, sequences and data augmentation were explored. Optimal performance was obtained by using a three-level pyramid MV-CNN with FIESTA, T2 and T1c sequences and data augmentation. Eye and tumor volumetric ICC were 0.997 and 0.996, respectively. Median [Interquartile range] DSC for eye, sclera, vitreous, lens, retinal detachment and tumor were 0.965 [0.950–0.975], 0.847 [0.782–0.893], 0.975 [0.930–0.986], 0.909 [0.847–0.951], 0.828 [0.458–0.962] and 0.914 [0.852–0.958], respectively. MV-CNN can be used to obtain accurate ocular structure and tumor segmentations in retinoblastoma.
Tumor microenvironment-adjusted prognostic implications of the KRAS mutation subtype in patients with stage III colorectal cancer treated with adjuvant FOLFOX
Authors: Park Hye Eun , Yoo Seung-Yeon , Cho Nam-Yun , Bae Jeong Mo , Han Sae-Won , Lee Hye Seung , Park Kyu Joo , Kim Tae-You , Kang Gyeong Hoon 
Published: July 2021

AbstractSeveral studies have reported that the prognostic effect of KRAS mutations on colorectal cancers (CRCs) varies depending on the type of mutation. Considering the effect of KRAS mutations on tumor microenvironment, we analyzed the prognostic significance of KRAS mutation types after adjusting for the tumor-infiltrating lymphocytes (TIL) and tumor-stromal percentage (TSP) statuses. In two independent cohorts, KRAS mutations were analyzed by Sanger sequencing and/or next-generation sequencing. TIL density and the TSP were quantified from whole-slide immunohistochemical images. KRAS-mutant CRCs were divided into three subgroups (G12D/V, other codon 12 mutations and codon 13 mutations) to examine their differential effect on TIL density, the TSP and recurrence-free survival (RFS). Among the KRAS mutations, only the G12D/V subgroups showed significantly less TIL infiltration than the wild-type CRCs. According to survival analysis, G12D/V mutations were associated with short RFS; codon 13 mutations showed discordant trends in the two cohorts, and other codon 12 mutations showed no significant association. Multivariate analysis further supported the prognostic value of G12D/V mutations. This result is not only consistent with a recent study suggesting the immunosuppressive effect of mutant KRAS but also provides insight into the type-specific prognostic effect of KRAS mutations.
The Yangian relations of Heisenberg spin chain model
Authors: Du Guijiao , Xue Kang , Zhou Chengcheng 
Published: July 2021

AbstractIn this paper, we investigate the Yangian relations of Heisenberg spin chain systems. Firstly, we consider the closed XXZ spin chain model, through the Heisenberg spin XXZ model, we found the Hamiltonians for one kind system of three adjacent partial particles interaction systems. The model’s constitution rules of energy levels and energy states which expand from the few-particle system to multi-particle system have good regularity. In this system, we found Yangian’s law and illustrate it through graphs. Secondly, we further consider the closed XXZ spin chain’s generalization of other three neighboring particles interaction systems from few-particle system to multi-particle system. Finally, we also discussed the laws of the three adjacent particles system of some models, they are the XXZ model with twist boundary condition, the open XXZ spin chain model and the XXZ model containing the next neighbor. In addition, not only XXZ model, XXX model, XY model and Ising model, but the relevant laws of spin-1 systems of these models were also discussed, they have similar rules to the XXZ model. Through calculation and research, the eigensystems of these models all have good Yangian and constitution laws.
Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank
Authors: Foo Heidi , Thalamuthu Anbupalam , Jiang Jiyang , Koch Forrest C. , Mather Karen A. , Wen Wei , Sachdev Perminder S. 
Published: July 2021

AbstractHere, we investigated the genetics of weighted functional brain network graph theory measures from 18,445 participants of the UK Biobank (44–80 years). The eighteen measures studied showed low heritability (mean h2SNP = 0.12) and were highly genetically correlated. One genome-wide significant locus was associated with strength of somatomotor and limbic networks. These intergenic variants were located near the PAX8 gene on chromosome 2. Gene-based analyses identified five significantly associated genes for five of the network measures, which have been implicated in sleep duration, neuronal differentiation/development, cancer, and susceptibility to neurodegenerative diseases. Further analysis found that somatomotor network strength was phenotypically associated with sleep duration and insomnia. Single nucleotide polymorphism (SNP) and gene level associations with functional network measures were identified, which may help uncover novel biological pathways relevant to human brain functional network integrity and related disorders that affect it.
Trajectories in glycated hemoglobin and body mass index in children and adolescents with diabetes using the common data model
Authors: Lee Yun Jeong , Yoo Sooyoung , Yi Soyoung , Kim Seok , Lee Chunggak , Cho Jihoon , Ahn Soyeon , Choi Sunkyu , Hwang Hee , Lee Young Ah , Shin Choong Ho , Yoon Hyung-Jin , Kim Kwangsoo , Song Eunhye , Choi Jin Ho , Yoo Han Wook , Kim Young-Hak , Oh Ji Seon , Kang Eun-Ae , Baek Ga Kyoung , Kim Jae Hyun 
Published: July 2021

AbstractWe evaluated trajectories of glycated hemoglobin (HbA1c) levels and body mass index z-scores (BMIz) for 5 years after diagnosis among Korean children and adolescents with type 1 diabetes (T1D) or type 2 diabetes (T2D) using the common data model. From the de-identified database of three hospitals, 889 patients < 15 years of age diagnosed with T1D or T2D (393 boys, 664 T1D patients) were enrolled. Diagnosis was defined as first exposure to antidiabetic drug at each center. Compared with T2D patients, T1D patients had lower BMIz at diagnosis (− 0.4 ± 1.2 vs. 1.5 ± 1.4, p < 0.001) and 3 months (− 0.1 ± 1.0 vs. 1.5 ± 1.5, p < 0.001), and higher HbA1c levels at diagnosis (10.0 ± 2.6% vs. 9.5 ± 2.7%, p < 0.01). After 3 months, HbA1c levels reached a nadir of 7.6% and 6.5% in T1D and T2D patients, respectively, followed by progressive increases; only 10.4% of T1D and 29.7% of T2D patients achieved the recommended HbA1c target (< 7.0%) at 60 months. T1D patients showed consistent increases in BMIz; T2D patients showed no significant change in BMIz during follow-up. Peri-pubertal girls with T1D had higher HbA1c and BMIz values. Achieving optimal glycemic control and preventing obesity should be emphasized in pediatric diabetes care.
High coverage COVID-19 mRNA vaccination rapidly controls SARS-CoV-2 transmission in long-term care facilities
Authors: De Salazar Pablo M. , Link Nicholas B. , Lamarca Karuna , Santillana Mauricio 
Published: July 2021

Abstract
Background
Residents of Long-Term Care Facilities (LTCFs) represent a major share of COVID-19 deaths worldwide. Measuring the vaccine effectiveness among the most vulnerable in these settings is essential to monitor and improve mitigation strategies.

Methods
We evaluate the early effect of the administration of BNT162b2-mRNA vaccine to individuals older than 64 years residing in LTCFs in Catalonia, Spain. We monitor all the SARS-CoV-2 documented infections and deaths among LTCFs residents once more than 70% of them were fully vaccinated (February–March 2021). We develop a modeling framework based on the relationship between community and LTCFs transmission during the pre-vaccination period (July–December 2020). We compute the total reduction in SARS-CoV-2 documented infections and deaths among residents of LTCFs over time, as well as the reduction in the detected transmission for all the LTCFs. We compare the true observations with the counterfactual predictions.

Results
We estimate that once more than 70% of the LTCFs population are fully vaccinated, 74% (58–81%, 90% CI) of COVID-19 deaths and 75% (36–86%, 90% CI) of all expected documented infections among LTCFs residents are prevented. Further, detectable transmission among LTCFs residents is reduced up to 90% (76–93%, 90% CI) relative to that expected given transmission in the community.

Conclusions
Our findings provide evidence that high-coverage vaccination is the most effective intervention to prevent SARS-CoV-2 transmission and death among LTCFs residents. Widespread vaccination could be a feasible avenue to control the COVID-19 pandemic conditional on key factors such as vaccine escape, roll out and coverage.
Construction of a thermoreversible chemical crosslinking network – a new exploration for the efficient reusability of commercial rubber
Authors: Wang Xiaoping , Wu Haijian , Liang Dong , Gong Yuzhu 
Published: July 2021

A thermoreversible rubber DSBR was prepared via a reaction between a nitroxide-based crosslinker and commercial styrene–butadiene rubber. Impressive recoveries of mechanical properties of DSBR were achieved for the alkoxyamine crosslinking network.
The Need for Increased Study of Infants and Toddlers Later Diagnosed With Childhood Apraxia of Speech
Authors: Overby Megan , Highman Chantelle 
Published: July 2021

Purpose
This article examines the need for increased research into the prelinguistic trajectory of childhood apraxia of speech (CAS). We discuss the significant gains made in the early identification of disorders such as autism spectrum disorder, fragile X syndrome, and Rett syndrome that have resulted through the study of early (i.e., prelinguistic) developmental behaviors of infants and toddlers at risk for these disorders. We suggest that notable gains in understanding CAS could be made by increasing investigative focus on infants and toddlers later diagnosed with CAS or who are at risk for it (i.e., have an older sibling diagnosed with the disorder).

Conclusions
Currently, there are few studies to guide clinical decision making for infants and toddlers who may have CAS. To address this gap, we present a call to action with recommendations for researchers and clinicians. We recommend more retrospective investigative designs be conducted, inclusive of retrospective parent questionnaires and retrospective home video analysis, as well as prospective longitudinal studies of at-risk infants. We suggest that studies not be limited to exploring an affected infant's vocal output, but that efforts be made to acquire a broad view of an affected infant's early developmental trajectory (e.g., social skills, eye gaze, and imitative skills). A more comprehensive understanding of CAS will guide clinicians not only in identification of the disorder but will inform treatment decisions as well.
Wavelet method optimised by ant colony algorithm used for extracting stable and unstable signals in intelligent substations
Authors: Jiang Tianyan , Yang Xiao , Yang Yuan , Chen Xi , Bi Maoqiang , Chen Jianfei 
Published: July 2021

AbstractPartial discharge (PD) signals are an important index to evaluate the operation state of intelligent substations. The correct distinction of PD pulse and interference pulse has become a challenging task. Because of the noise and the low signal‐to‐noise ratio, the stable signals become non‐stationary. The selection of a wavelet basis, the selection rule of threshold λ and the design of the threshold function are the key factors affecting the final denoising effect. Therefore, an enhanced ant colony optimisition wavelet (ACOW) algorithm was applied to find the global optimal threshold through the continuous derivative threshold function and the ant colony optimisation (ACO) algorithm. At the same time the efficiency of adaptive search calculation, was also significantly improved. The method of the ACOW algorithm was compared with the soft wavelet method, gradient‐based wavelet method and the genetic optimisation wavelet (GOW) method. Using these four methods to denoise four typical signals, different mean square errors (MSE), magnitude errors (ME) and time costs were obtained. Interestingly, the results show that the ACOW method can achieve the minimum MSE and has less time cost. It generates significantly smaller waveform distortion than the other three threshold estimation methods. In addition, the high efficiency and good quality of the output signals are beneficial to the diagnosis of local discharge signals in intelligent substations.
Singly and doubly deuterated formaldehyde in massive star-forming regions
Authors: Zahorecz S. , Jimenez-Serra I. , Testi L. , Immer K. , Fontani F. , Caselli P. , Wang K. , Onishi T. 
Published: July 2021

Context. Deuterated molecules are good tracers of the evolutionary stage of star-forming cores. During the star formation process, deuterated molecules are expected to be enhanced in cold, dense pre-stellar cores and to deplete after protostellar birth.
Aims. In this paper, we study the deuteration fraction of formaldehyde in high-mass star-forming cores at different evolutionary stages to investigate whether the deuteration fraction of formaldehyde can be used as an evolutionary tracer.
Methods. Using the APEX SEPIA Band 5 receiver, we extended our pilot study of the J = 3 →2 rotational lines of HDCO and D2CO to eleven high-mass star-forming regions that host objects at different evolutionary stages. High-resolution follow-up observations of eight objects in ALMA Band 6 were performed to reveal the size of the H2CO emission and to give an estimate of the deuteration fractions HDCO/H2CO and D2CO/HDCO at scales of ~6″ (0.04–0.15 pc at the distance of our targets).
Results. Our observations show that singly and doubly deuterated H2CO are detected towards high-mass protostellar objects (HMPOs) and ultracompact H II regions (UC H II regions), and the deuteration fraction of H2CO is also found to decrease by an order of magnitude from the earlier HMPO phases to the latest evolutionary stage (UC H II), from ~0.13 to ~0.01. We have not detected HDCO and D2CO emission from the youngest sources (i.e. high-mass starless cores or HMSCs).
Conclusions. Our extended study supports the results of the previous pilot study: the deuteration fraction of formaldehyde decreases with the evolutionary stage, but higher sensitivity observations are needed to provide more stringent constraints on the D/H ratio during the HMSC phase. The calculated upper limits for the HMSC sources are high, so the trend between HMSC and HMPO phases cannot be constrained.
Bridging hybrid- and full-kinetic models with Landau-fluid electrons
Authors: Finelli F. , Cerri S. S. , Califano F. , Pucci F. , Laveder D. , Lapenta G. , Passot T. 
Published: July 2021

Context. Magnetic reconnection plays a fundamental role in plasma dynamics under many different conditions, from space and astrophysical environments to laboratory devices. High-resolution in situ measurements from space missions allow naturally occurring reconnection processes to be studied in great detail. Alongside direct measurements, numerical simulations play a key role in the investigation of the fundamental physics underlying magnetic reconnection, also providing a testing ground for current models and theory. The choice of an adequate plasma model to be employed in numerical simulations, while also compromising with computational cost, is crucial for efficiently addressing the problem under study.
Aims. We consider a new plasma model that includes a refined electron response within the “hybrid-kinetic framework” (fully kinetic protons and fluid electrons). The extent to which this new model can reproduce a full-kinetic description of 2D reconnection, with particular focus on its robustness during the nonlinear stage, is evaluated.
Methods. We perform 2D simulations of magnetic reconnection with moderate guide field by means of three different plasma models: (i) a hybrid-Vlasov-Maxwell model with isotropic, isothermal electrons, (ii) a hybrid-Vlasov-Landau-fluid (HVLF) model where an anisotropic electron fluid is equipped with a Landau-fluid closure, and (iii) a full-kinetic model.
Results. When compared to the full-kinetic case, the HVLF model effectively reproduces the main features of magnetic reconnection, as well as several aspects of the associated electron microphysics and its feedback onto proton dynamics. This includes the global evolution of magnetic reconnection and the local physics occurring within the so-called electron-diffusion region, as well as the evolution of species’ pressure anisotropy. In particular, anisotropy-driven instabilities (such as fire-hose, mirror, and cyclotron instabilities) play a relevant role in regulating electrons’ anisotropy during the nonlinear stage of magnetic reconnection. As expected, the HVLF model captures all these features, except for the electron-cyclotron instability.