bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface modification of Polyether Ether Ketone (PEEK) via sulfonation and hydroxyapatite coating: impact on shear bond strength with resin composites
Authors: Htay Thae Phyu , Peampring Chaimongkon , Thammajaruk Putsadeeporn 
Published: December 2024

Abstract

Purpose: This study evaluates the effects of various polyetheretherketone (PEEK) surface treatments on its shear bond strength (SBS) with flowable resin composites.
Methods: A total of 120 PEEK disks were categorized into five groups: untreated PEEK (control), sandblasted with 50 µm alumina (Sa PEEK), etched with 98% sulfuric acid for 1 minute (S PEEK), hydroxyapatite-coated sulfonated PEEK (HA PEEK), and phosphoric acid-etched HA-coated PEEK (HAP PEEK). Each group was further divided into two subgroups (n=12) based on the bonding agent used: Scotchbond Universal Plus (Sc) and Single Bond Universal (Si). After applying the bonding agent, the resin composite was light-cured onto the PEEK surface. The SBS was evaluated using a universal testing machine after thermocycling for 5000 cycles. Two-way and one-way ANOVA, followed by Tukey’s HSD for post-hoc comparisons, were used for statistical analysis (α = 0.05)
Results: HA PEEK exhibited the highest SBS values (Si: 25.87 ± 2.89 MPa; Sc: 26.49 ± 3.14 MPa, P < 0.05), while untreated PEEK showed the lowest. No significant difference was observed between Sc and Si in most groups, except that Si demonstrated significantly higher SBS in the S PEEK group.
Conclusions: HA PEEK consistently achieved the highest SBS, indicating that combining sulfonation with HA coating is an effective strategy to enhance bonding between PEEK and flowable resin composites.
Real-world effectiveness of a single-day regimen for transcranial magnetic stimulation using Optimized, Neuroplastogen-Enhanced techniques in Depression (ONE-D)
Authors: Vaughn Donald A , Marino Brooke , Engelbertson Alex , Dojnov Aleksandra , Weiss Nick , Vila-Rodriguez Fidel , Nanos Georgine , Downar Jonathan 
Published: December 2024

Abstract

Background: Conventional transcranial magnetic stimulation (TMS) regimens are logistically burdensome, requiring days or weeks of clinic visits. Here we describe a TMS regimen enabling delivery of an entire therapeutic course in a single day.
Methods: This retrospective case series reports outcomes for an optimized, neuroplastogen-enhanced depression (ONE-D) treatment regimen delivering 600-pulse iTBS (120% MT) targeting left DLPFC via scalp heuristic, every 30 minutes for 20 sessions in 9.5 hours, enhancing neuroplasticity via single-dose d-cycloserine (125 mg) and lisdexamfetamine (20 mg), off-label, given 1 hour pre-treatment. 32 TMS-eligible adults with medication-resistant unipolar depression underwent the ONE-D regimen, with assessments on day-of-treatment then weekly x 6 weeks (HDRS-17, BDI-II, PHQ-9, and GAD-7).
Results: Every patient completed the regimen successfully, with no serious adverse events (mean scalp discomfort, 5.8±2.1/10). Response was not immediate but followed an exponential-decay trajectory over the 6-week followup: mean weekly scores of 22.6±5.3(baseline), 13.5±6.4, 10.6±6.4, 7.9±4.9, 6.6±4.9, 6.3±4.8, 5.5±4.2 (HDRS-17), 37.5±9.0(baseline), 23.8±12.2, 17.1±11.1, 14.1±11.2, 11.0±8.7, 9.5±8.2, 7.6±7.8 (BDI-II,) 18.4±3.5(baseline), 11.4±5.1, 9.4±5.7, 6.9±5.2, 6.0±3.9, 5.3±4.0, 4.6±4.2 (PHQ-9), 14.3±5.2(baseline), 8.7±4.5, 6.4±5.0, 4.3±4.0, 3.8±3.6, 3.3±3.3, 3.1±2.7 (GAD-7). Response / remission rates (cross-sectional, not aggregated) were 90.3% and 74.2% (HDRS-17), 93.5% and 71.0% (BDI-II), 90.3% and 58.1% (PHQ-9), 93.3% and 76.7% (GAD-7) at week 6, and 92.6% and 77.8% (HDRS-17), 92.3% and 73.1% (BDI-II), 86.4% and 65.4% (PHQ-9), 91.7% and 80.0% (GAD-7) at week 12.
Conclusion: Delivery of an effective TMS course in one day appears feasible, safe, and well-tolerated. With neuroplastogen-enhancement, despite non-personalized, scalp-based targeting, the response and remission rates appeared robust and sustained in representative clinical populations. Follow-up studies may allow further acceleration of the regimen and generalization to other TMS indications.
Nicking Enzyme Assisted Amplification Combined with CRISPR-Cas12a System for One-Pot Sensitive Detection of APE1
Authors: Dai Wei , Wang Han , Xiao Xian , Li Yiyuan , Zhou Jiahui , Jiang Dayang , Luo Yangkang , Xiao Xianjin , Li Longjie , Yu Jie , Yan Bei 
Published: December 2024

Abstract

Apurinic/apyrimidinic endonuclease 1 (APE1) is a critical enzyme in the base excision repair (BER) pathway, essential for preserving cellular equilibrium. Variations in APE1 activity within blood or tissues can provide significant insights for clinical cancer screening and disease diagnosis. Consequently, the detection of APE1 activity is critical for clinical diagnostics. However, there is currently a deficiency in rapid, straightforward, and sensitive methods for APE1 detection. To address this issue, we developed a method that integrates nicking enzyme assisted amplification (NEAA) with CRISPR-Cas12a signal amplification, enabling one-pot detection of APE1 activity. This method utilizes NEAA to produce a substantial quantity of target DNA that is complementary to the crRNA, thereby triggering the trans-cleavage activity of Cas12a. The activated Cas12a then amplifies and emits signals by cleaving the reporter probe. Our strategy allows for the swift and precise detection of APE1, with a detection threshold of 1×10− 6 U/mL and a linear detection range of 5×10− 6 to 0.1 U/mL. It has been effectively utilized for the detection of APE1 in biological samples.
Adiponectin influences the behavior of stem cells in hormone-resistant breast cancer
Authors: Naimo Giuseppina Daniela , Forestiero Martina , Giordano Francesca , Leonetti Adele Elisabetta , Gelsomino Luca , Panno Maria Luisa , Ando Sebastian , Mauro Loredana 
Published: December 2024

Abstract

Background: Overcoming endocrine-resistance is the major challenge in treating Estrogen receptor (ER)-positive breast cancer. Breast Cancer Stem Cells (BCSCs) are blamed to be the driving force behind poor clinical outcomes and low therapeutic response. Notably, tumor microenvironment (TME) exerts a selective pressure on BCSCs behavior. The most prevalent cellular component of the TME is represented by adipocytes, which secrete reduced levels of adiponectin in obesity, promoting ERα-positive breast cancer growth and progression. Here, we examined the impact of low adiponectin levels on the enrichment of BCSC subpopulations and the underlying molecular mechanisms by which this may contribute to the maintenance of hormone-resistance in breast cancer.
Methods: MCF-7 wild type (WT) and tamoxifen-resistant (TR) cells were grown as mammospheres. Mammospheres Forming Efficiency (MFE) and self-renewal were evaluated by mammospheres count. Flow cytometry analysis were performed to assess CD44+/24- cell ratio, ALDH1 expression, apoptosis, ROS production, and mitochondrial membrane potential. mRNA levels of stemness, epithelial to mesenchymal transition (EMT), proliferation and cell cycle markers were quantified by qRT-PCR. Western blotting was used to detect protein levels. DNA quantitation was carried out to investigate growth rate. nLC-MS/MS was employed to profile and compare the proteome of BCSCs. The differentially expressed proteins (DEPs) were intersected with data from MetacoreTM dataset.
Results: Our study demonstrated that adiponectin increased the percentage of CD44+/CD24-/ALDH1+ stem-like cells in TR MCF-7 compared to hormone-responsive WT MCF-7 mammospheres. Moreover, adiponectin induced cell cycle arrest in G0/G1 phase, supported by cyclin D1 and Ki67 decreased levels, concomitant with an increased expression of cyclin-dependent kinase inhibitors p21 and p27 in TR MCF-7 cells. Consistent with these data, we observed an enhanced ability of adiponectin-treated TR MCF-7 cells to escape from apoptosis, sustained by reduced ROS production and the maintenance of mitochondrial membrane potential, critical to prevent cytochrome C release.
Conclusions: Overall, we have shown that low levels of adiponectin promote stem-like features in TR MCF-7 cells, contributing to select the hormone-resistant phenotype. Understanding the molecular mechanisms through which low levels of adiponectin potentiate stemness in endocrine-resistant cells may disclose novel therapeutic approaches to treat obese patients developing hormone-resistant breast cancer.
Awareness of, practical experience in, and education need for health advocacy in Japan: a preliminary study among physicians in Japan
Authors: Mizuma Kimiko , Amitani Marie , Sakiyama Hayato , Ibusuki Rie , Owaki Tetsuhiro 
Published: December 2024

Abstract

Background Health advocacy, as performed by physicians, is an important global agenda for tackling health inequities, especially in the primary care area. However, few physicians are trained be able to perform health advocacy in Japan. This descriptive preliminary study aimed to clarify the current situation regarding health advocacy among Japanese physicians and propose specific strategies for its dissemination.Methods A questionnaire survey was distributed to 1,296 medical institutions in Kagoshima Prefecture to clarify Japanese physicians’ awareness of, practical experiences in, and education need for health advocacy.Results Physicians strongly perceived the need for health advocacy on the micro, meso, and macro levels (95.3%, 82.4%, and 77.7%, respectively). However, about 90% of the physicians did not actually put meso- and macro-level health advocacy into practice. Overall, specific social issues were less recognized as targets of health advocacy as its range of actions broadened from the micro to the meso and to the macro levels. And even given that overall trend, different trends in awareness of the need for and actual practice in health advocacy were observed among each social issue. In total, 73.6% of the physicians had never heard the term “health advocacy”, and 45.9% did not think it was their responsibility. However, 69.6% of the physicians showed a positive attitude toward participating in health advocacy education. Over 62% of the physicians supported undergraduate and lifelong medical education as effective dissemination measures of health advocacy among Japanese physicians. Notably, however, the physicians who were more likely to be rooted in primary care expressed less willingness to participate in lifelong educational opportunities.Conclusions The findings of this study suggest that feasible lifelong medical education is needed for Japanese physicians to acquire the knowledge, attitudes, and practical skills necessary to perform health advocacy on the meso and macro levels. Furthermore, the introduction of health advocacy as a theme of undergraduate medical education in Japan is needed. To develop both general theoretical research and practical educational strategies research is required that can lead to effective health advocacy solutions for health inequities.
Exploring Lichen Derived Compounds for Therapeutic Potential in Diabetes Management
Authors: Abirami S. , Hemashenpagam N. 
Published: December 2024

Abstract

Nature has been a profound source of medicinal agents for millennia, with numerous modern drugs derived from natural sources. Many of these discoveries stem from traditional medicine practices. Plants, in particular, are rich in secondary metabolites like tannins, terpenoids, alkaloids, and flavonoids, known for their antimicrobial properties. Among these, lichens, which are symbiotic organisms consisting of a fungus and an alga, present significant potential for medical exploration. Studies have shown that lichen metabolites, such as depsides, depsidones, and usnic acid, exhibit activity against mycobacteria and Gram-positive bacteria. With the growing ineffectiveness of some conventional drugs, there is renewed interest in lichen compounds. This study focuses on the antimicrobial and antioxidant activities of lichens from Ooty, Tamil Nadu, India. Extracts from these lichens were analyzed using LC-MS and various assays, including phenol content, FRAP, ORAC, and DPPH, revealing substantial antioxidant activity. In vitro tests for inhibiting pancreatic lipase, α-glucosidase, and α-amylase, along with in silico predictions of pharmacokinetic properties, toxicity risks, and molecular interactions, demonstrated notable inhibitory potential. This research enhances our understanding of bioactive compounds in lichens from temperate and polar regions and highlights their potential as natural alternatives for treating diseases linked to oxidative stress and metabolic syndrome.
Evaluation of water quality by Fuzzy DEMATEL and statistics analysis
Authors: Askari Kaveh Ostad Ali , Kianmehr Peiman 
Published: December 2024

Abstract

Significant deterioration in water quality produced by natural components and human activities can mark anthropological health and ecologies. Therefore, it is significant to check the water quality on a regular basis. This study emphases on the location of 21 water components and 14 diverse water monitoring stations along the Shirin rood River. Multivariate analysis is used in this study. The PCA examinesthe origin of each parameter that contributes to river pollution. The AHC technique is used to group all water qualitymonitoring stations depend on the level of river contamination regions. The study then expands the Fuzzy Decision Trail and Evaluation Institute (FDEMATEL) to discovery causal relationships amongst river pollutants. The results display that 5 key PCs with 53.128% of total alteration were gained from the water quality information. AHC categorizes three clustered areas as low, medium and high contamination. The results of this study will help disclose significant information about river water quality in order to managepollution sources and thereby maintaininhabitants and ecosystem health.
Unveiling the Hidden: Prevalence of Dystrophic Calcification in Digital Orthopantomograph Through a Retrospective Study
Authors: Jain Swasti , Singh Mohitpal , Mathur Hemant 
Published: December 2024

Abstract

OBJECTIVE- Soft tissue calcifications in the head and neck region are a rare occurrence that are frequently seen on digital panoramic radiographs. This article delves into panoptic exploration to examine and evaluate the prevalence of dystrophic calcification and other soft tissue calcifications in digital orthopantomographs across diverse patient population through a retrospective analysis. METHOD AND METHODOLOGY-A systematic analysis of a small dataset of 300 patients between the ages of 12 to 74 years were studied using their digital OPGs. These radiographs were utilized to focus on identifying and categorizing dystrophic calcifications, and other soft tissue calcifications which includes calcified stylohyoid ligament, tonsillolith, carotid artery calcification, sialolith of submandibular gland, rhinolith, phlebolith and antrolith based on prevalence according to gender, age and site using Chi square test and ANOVA test. RESULTS- Findings of the study showed that soft tissue calcifications including dystrophic calcifications are remarkably common manifestation in digital OPGs. Notably, the prevalence of these calcifications were found more in male than in female. Presence of styloid ligament calcification(28.7%) and carotid artery calcification(16.7%) were the two most common soft tissue calcifications found in oral maxillofacial region. Additionally, a significant percentage of cases showed calcifications in the carotid arteries, raising serious questions regarding vascular consequences.Other soft tissue components showed distinct patterns of calcification like sialolith, phleboliths, rhinoliths, antrolith and tonsillolith emphasize more on their potential diagnostic use. Also, the prevalence of all the calcifications increased with increase in age.[15] CONCLUSION-Soft tissue calcifications are frequently seen on panoramic radiographs. Dentists should be able to recognize it and determine the differential diagnosis of the primary soft tissue calcifications in the dentomaxillofacial region when it occurs. Early diagnosis of atherosclerotic conditions and prompt guidance regarding the patient's medical condition may be of high importance in patients’ health.
Empirical Evaluation for Cricket CommentaryDecoder
Authors: BODKHE SAHIL , Rajasekaran Nandhini , Nagesh Chinmay 
Published: December 2024

Abstract

Cricket is not just a sport but a global phenomenon, attracting billions of fans and generating immense revenue through broadcasting rights, streaming platforms, and fantasy sports applications. With the advent of professional leagues like the Indian Premier League (IPL) and Big Bash League (BBL), cricket has become a data-rich and analytics-driven game. Real- time event classification from live commentary is crucial for powering these ecosystems, from enhancing viewer experiences to enabling fantasy leagues and predictive analytics. This project aims to develop a real-time cricket commentary decoder to classify events accurately from unstructured and informal textual commentary. Cricket commentary often includes colloquial lan- guage, ambiguous phrases, and context-dependent expressions, which traditional rule-based Natural Language Processing (NLP) techniques struggle to handle effectively. The solution incorpo- rates innovative strategies to address sense disambiguation by intentionally removing clear event-indicative keywords, thereby simulating real-world complexity. By tackling the limitations of rule-based systems such as their over reliance on explicit keywords and inability to handle ambiguous contexts, the system achieves robust event classification for runs, outs, extras, and dots game actions. Designed to seamlessly integrate with real- time sports tracking applications, the decoder enables dynamic updates and API calls. By balancing computational efficiency with classification accuracy, this project not only addresses the technical challenges of decoding live commentary but also supports the growing role of data and analysis in the modern cricket ecosystem. To overcome these challenges, the proposed system employs advanced machine learning methods, including LSTM, GRU, SVM, Logistic classifiers, and boosting techniques like LightGBM.
Implementation of All-optical Trinary State Half-adder Using Semiconductor Optical Amplifier Supported by Simulation Experiment
Authors: Mondal Tanmay , Biswas Subhendu 
Published: December 2024

Abstract

The bottleneck of electronic systems due to the increase of requirements of very large bandwidth and speed was removed by photonic systems owing to its inherent parallelism and high speed of operation which also made it a strong contender in optical data processors. In a Photon one can encode digital information in its Amplitude, Frequency, Phase and Polarization properties. As frequency is the basic characteristic of light, so frequency encoding principle is the most reliable one among all other encoding principles. In Frequency encoding, the schemes become immune to noise. The frequency of light does not change normally after reflection, refraction or absorption. It can be used in several faithful high bandwidth real-time optical logic processors which in the future can dominate the optical communication and data processing systems. For different frequency-shifting operations, we can use Semiconductor Optical Amplifier (SOA) in real-time. In this proposed scheme, using the SOA, the Trinary state-based half adder has been proposed for optical communication, where in the Trinary state ‘-1’ logic state is represented by a frequency ν1 then the ‘0’ state is represented by another frequency ν2 and the ‘1’ logic state is represented by a frequency ν3. The photonic schemes proposed are also being verified by Matlab Simulink simulation.
СОВЕТСКО-ИТАЛЬЯНСКОЕ ВЗАИМОДЕЙСТВИЕ В КОНЦЕ 1950-Х ГГ.: ЭКОНОМИЧЕСКИЙ И КУЛЬТУРНЫЙ АСПЕКТЫ
Authors: Гиголаев Г.Е. 
Published: December 2024

Культурное и экономическое взаимодействие между государствами, входившими впротивоборствующие военнополитические блоки в годы холодной войны, тесно связано с понятиями мягкая сила и мирное сосуществование, возникшими взападном и восточном политическом лексиконе, соответственно. Активизация экономических и культурных связей между СССР и Италией на рубеже 1950х1960х гг. способствовала налаживанию политического взаимодействия, хотя оно было обусловлено и чисто политическими причинами, связанными с ранней разрядкой в отношениях между СССР и странами Запада.
Cultural and economic interaction between states that were part of the opposing militarypolitical blocs during the Cold War years is closely related to the concepts of soft power and peaceful coexistence that emerged in the Western and Eastern political lexicon, respectively. The intensification of economic and cultural relations between the USSR and Italy at the turn of the 1950s 1960s. contributed to the establishment of political interaction, although it was also due to purely political reasons related to early dtente in relations between the USSR and Western countries.
РУССКАЯ КУЛЬТУРА В ОБЩЕЕВРОПЕЙСКОМ КОНТЕКСТЕХУДОЖЕСТВЕННОЕ НАСЛЕДИЕ РУССКОГО ЗАРУБЕЖЬЯВ ВЕЛИКОБРИТАНИИ
Authors: Щеблыгина И.В. 
Published: December 2024

В истории процесса открытия и признания русского искусства за рубежом огромная роль принадлежит русской художественной эмиграции. Продолжив отечественную культурную традицию, она вписала свою страницу в историю мировой художественной культуры. Статья посвящена одному из малоизученных аспектов русского культурного наследия в мире творческому наследию художников русского зарубежья в Великобритании. Русское художественное собрание в музее Эшмолеан и доммузей Л.О. Пастернака в Оксфорде, мозаики Б. Анрепа, украшающие художественные галереи и общественные здания в Лондоне, серия панно Л. Бакста в музее Уодесдон, витражи Марка Шагала в графстве Кент все это, созданное русскими художниками, органичная часть культурного пространства Великобритании.
Russian artistic emigration has played an important part in the historic process of discovery and recognition of Russian arts. Having followed Russian cultural traditions the emigration wrote down its own page in the history of world artistic culture. This article speaks about the artistic heritage of Russian emigration artists in the United Kingdom which appeared to be one of little studied aspects of Russian cultural heritage in the world. Russian arts collection of Ashmolean Museum, memorial house of Leonid Pasternak in Oxford, mosaics by Boris Anrep decorating art galleries and public buildings in London, series of canvas wall panels by Leo Bakst in Waddesdon museum, stainedglass panels by Marc Chagall in Kent county all these creations by Russian artists blended in with the culture of Great Britain.
МОЛОДЕЖЬ ЮГА РОССИИВ ЧЕХОСЛОВАЦКОЙ РЕСПУБЛИКЕ (1920–1930-е гг.)
Authors: Барбарунова З.А. , Копpшивова А.В. 
Published: December 2024

Данная работа представляет собой опыт историкосоциологического исследования групп эмигрантов в возрасте до 35 лет. Рамки исследования ограничиваются уроженцами Области Войска Донского, Области Терского казачьего войска, Кубанской области и Черноморской губернии.
This work is an example of the historically sociological research, analyzing the groups of Don, Kuban and Terek immigrants up to 35yearold, who came to Czechoslovakia to study in the period of the Russian auxiliary actions of Czechoslovakia. These groups include the young generation of Cossacks and urban citizens from the Don, Kuban, Terek, and also Czech colonists from the Black Sea provinces.