bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for return to work in colorectal cancer survivors
Authors: Yuan Chung‐Mao , Wang Chung‐Ching , Wu Wei‐Te , Ho Ching‐Liang , Chen Wei‐Liang 
Published: May 2021

AbstractBackground: The increasing incidence of colorectal cancer among individuals in the productive age‐group has adversely affected the labor force and increased healthcare expenses in recent years. Return to work (RTW) is an important issue for these patients. In this study, we explored the factors that influence RTW and investigated the influence of RTW on survival outcomes of patients with colorectal cancer.Methods: Data of individuals (N = 4408) in active employment who were diagnosed with colorectal cancer between 2004 and 2010 were derived from 2 nationwide databases. Subjects were categorized into 2 groups according to their employment status at 5‐year follow‐up. Logistic regression analysis was performed to identify the factors associated with RTW. Survivors were further followed up for another 8 years. Propensity score matching was applied to ensure comparability between the two groups, and survival analysis was performed using the Kaplan–Meier method.Results: In multivariable regression analysis for 5‐year RTW with different characteristics, older age (OR: 0.57 [95% CI, 0.48–0.69]; p < 0.001), treatment with radiotherapy (OR: 0.69 [95% CI, 0.57–0.83]; p < 0.001), higher income (OR: 0.39 [95% CI, 0.32–0.47]; p < 0.001), medium company size (OR: 0.78 [95% CI, 0.63–0.97]; p = 0.022), and advanced pathological staging (stage I, OR: 16.20 [95% CI, 12.48–21.03]; stage II, OR: 13.12 [95% CI, 10.43–16.50]; stage III, OR: 7.68 [95% CI, 6.17–9.56]; p < 0.001 for all) revealed negative correlations with RTW. In Cox proportional hazard regression for RTW and all‐cause mortality, HR was 1.11 (95% CI, 0.80–1.54; p = 0.543) in fully adjusted model.Conclusion: Older age, treatment with radiotherapy, higher income, medium company size, and advanced pathological stage showed negative correlations with RTW. However, we observed no significant association between employment and all‐cause mortality. Further studies should include participants from different countries, ethnic groups, and patients with other cancers.
Engineering of a Thermostable Biocatalyst for the Synthesis of 2‐O‐Glucosylglycerol
Authors: Franceus Jorick , Ubiparip Zorica , Beerens Koen , Desmet Tom 
Published: May 2021

Abstract2‐O‐Glucosylglycerol is accumulated by various bacteria and plants in response to environmental stress. It is widely applied as a bioactive moisturising ingredient in skin care products, for which it is manufactured via enzymatic glucosylation of glycerol by the sucrose phosphorylase from Leuconostoc mesenteroides. This industrial process is operated at room temperature due to the mediocre stability of the biocatalyst, often leading to microbial contamination. The highly thermostable sucrose phosphorylase from Bifidobacterium adolescentis could be a better alternative in that regard, but this enzyme is not fit for production of 2‐O‐glucosylglycerol due to its low regioselectivity and poor affinity for glycerol. In this work, the thermostable phosphorylase was engineered to alleviate these problems. Several engineering approaches were explored, ranging from site‐directed mutagenesis to conventional, binary, iterative or combinatorial randomisation of the active site, resulting in the screening of ∼3,900 variants. Variant P134Q displayed a 21‐fold increase in catalytic efficiency for glycerol, as well as a threefold improvement in regioselectivity towards the 2‐position of the substrate, while retaining its activity for several days at elevated temperatures.
Serum exosomes accelerate diabetic wound healing by promoting angiogenesis and ECM formation
Authors: Chen Liushan , Qin Linghao , Chen Chujun , Hu Qiong , Wang Junjian , Shen Juan 
Published: May 2021

AbstractNonhealing wounds in diabetes remain a global clinical and research challenge. Exosomes are primary mediators of cell paracrine action, which are shown to promote tissue repair and regeneration. In this study, we investigated the effects of serum derived exosomes (Serum‐Exos) on diabetic wound healing and its possible mechanisms. Serum‐Exos were isolated from blood serum of normal healthy mice and identified by transmission electron microscopy and western blot. The effects of Serum‐Exos on diabetic wound healing, fibroblast growth and migration, angiogenesis and extracellular matrix (ECM) formation were investigated. Our results showed that the isolated Serum‐Exos exhibited a sphere‐shaped morphology with a mean diameter at 150 nm, and expressed classical markers of exosomes including HSP70, TSG101, and CD63. Treatment with Serum‐Exos elevated the percentage of wound closure and shortened the time of healing in diabetic mice. Mechanistically, Serum‐Exos promoted granulation tissue formation and increased the expression of CD31, fibronectin and collagen‐ɑ in diabetic mice. Serum‐Exos also promoted the migration of NIH/3T3 cells, which was associated with increased expression levels of PCNA, Ki67, collagen‐α and fibronectin. In addition, Serum‐Exos enhanced tube formation in human umbilical vein endothelial cells and induced the expression of CD31 at both protein and messenger RNA levels. Collectively, our results suggest that Serum‐Exos may facilitate the wound healing in diabetic mice by promoting angiogenesis and ECM formation, and show the potential application in treating diabetic wounds.
Gender‐based outcomes of coronary bifurcation stenting: A report from the National Readmission Database
Authors: Osman Mohammed , Ghaffar Yasir Abdul , Osman Khansa , Kheiri Babikir , Mohamed Mohamed M. G. , Kawsara Akram , Balla Sudarshan , Roda‐Renzelli Anthony , Daggubati Ramesh 
Published: May 2021

AbstractBackgroundThere is a paucity of data focusing on women's outcomes after percutaneous coronary interventions (PCI) for coronary bifurcation lesions (CBLs).MethodsPatients who received PCI for CBLs in the context of acute coronary syndrome (ACS) during the period of 01 October 2015– 31 December 2017, were identified from the United States National Readmission Database. The primary endpoint of this study was in‐hospital major adverse events (MAEs). The secondary endpoints were in‐hospital mortality, vascular complications, major bleeding, post‐procedural bleeding, need for blood transfusion, severe disability surrogates (non‐home discharge and need for mechanical ventilation), resources utilization surrogates (length of stay and cost of hospitalization), and 30‐day readmission rate. A 1:1 propensity score matching was used to compare the outcomes between women and men.ResultsA total of 25,050 (women = 7,480; men = 17,570) patients were included in the current analysis. After propensity score matching, women had higher in‐hospital MAEs (7 vs 5.2%, p < .01), major bleeding (1.8 vs 0.8%, p < .01), post‐procedural bleeding (6.1 vs 3.4%, p < .01), need for blood transfusion (6.4 vs 4.2%, p < .01), non‐home discharges (10.2 vs 7.1%; p < .01), longer length of hospital stay (3 days [IQR 2–6] vs. 3 days [IQR 2–5], p < .01) and higher 30‐day readmission rate compared to men (14.2 vs. 11.5%, p < .01).ConclusionsAmong all‐comers who received PCI for CBLs in the context of ACS, women suffered higher MAEs and 30‐day readmission rates compared to their men' counterparts. The higher MAEs in the women were mainly driven by higher postprocedural bleeding rates and the need for blood transfusion.
Patent foramen ovale closure with vena cava thrombus: You need an arm and a neck!
Authors: Qintar Mohammed , Villablanca Pedro , Lee James , Wang Dee Dee , Frisoli Tiberio , O’Neill Brian , O’Neill William W , Eng Marvin H 
Published: May 2021

AbstractIn patients with challenging femoral vein anatomy, transcatheter patent foramen ovale (PFO) closure can be safely and effectively be done through the jugular veins guided by ICE from the arm. This novel technique can potentially save resources (anesthesia and TEE) and provide an option for patients without a femoral option.
Unusual imaging findings of SARS‐CoV‐2 in HIV‐positive patient : A case report
Authors: Charifi Yahya , Rabhi Samira , Sekkat Ghita , Haloua Meryem , Alaoui Lamrani Moulay Youssef , Ouadnouni Yassine , Boubbou Meryeme , Maaroufi Mustapha , Alami Badreeddine 
Published: May 2021

AbstractConsidering SARS‐CoV‐2 as a major differential diagnosis of pneumocystis in HIV‐positive patients even if the lesions are typical.
Arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia
Authors: Ott Ashley , Venkataraman Vinayak , Badran Yousef R. , Goldman Rose , Spasic Smiljana , Vyas Darshali A. , Amrein Philip , McAfee Steven , Brunner Andrew , Fathi Amir T. , Narayan Rupa 
Published: May 2021

AbstractArsenic trioxide (ATO) is generally well tolerated for treatment of APL. We present a patient with severe watery diarrhea and pancreatitis thought to be due to ATO toxicity in the setting of obesity and acute kidney injury. Future studies evaluating ATO levels in patients experiencing toxicities may help guide dose modifications.
Presence of SARS‐CoV‐2 in plural effusion with COVID‐19 patients
Authors: Ataee Zahra , Hasanzadeh Sepideh , Mehri Ali , Sayadi Mahdiyeh , Ataei Leila , Amel Jamehdar Saeid 
Published: May 2021

AbstractRT‐PCR of OP, NP swabs, is the gold standard test for the diagnosis of COVID‐19. CT scan plays an important role in the diagnostic evaluation of COVID‐19. Both methods increase the tracing disease. Even though pleural involvement has been reported less, it has been observed in significant cases.
Twin anemia polycythemia sequence in dichorionic diamniotic twins: A case report and review of the literature
Authors: Kanagaretnam Dhusyanthy , Nayyar Roshini , Zen Monica 
Published: May 2021

AbstractAlthough rare, literature demonstrates evidence that vascular anastomoses do occur in dichorionic twins. Therefore, twin anemia polycythemia sequence should be considered as a differential diagnoses in dichorionic twins if there is suspicion on antenatal ultrasound.
Coronary artery bypass grafting in a 12‐year‐old girl with familial hypercholesterolemia
Authors: Al‐Dairy Alwaleed , Srour Samir , Hasan Hasan , Alkasser Ola , Alkasser Mhd Khaled 
Published: May 2021

AbstractAs CABG operation is indicated in children with familial hypercholesterolemia, it seems that bilateral internal thoracic arteries are the preferred grafts, taking into consideration its superiority over venous graft regarding patency and growth.
Steroid therapy is effective for IgA nephropathy after liver transplantation in a pediatric patient
Authors: Tamura Hiroshi , Kuraoka Shohei , Nakazato Hitoshi 
Published: May 2021

AbstractHepatic IgA nephropathy is a complication of chronic liver disease. IgA nephropathy after liver transplantation is rare, especially in children, and carries a significant risk factor for chronic renal failure and mortality. In cases without viral hepatitis, steroid therapy may be useful for IgA nephropathy associated with liver dysfunction.
Mirror writing in a patient with frontal lobe epilepsy
Authors: Vityala Yethindra , Galako Tatiana , Kadyrova Aliya , Mamytova Elmira , Toktomametova Anara , Molchanova Olesya , Mamatov Sagynali , Tagaev Tugolbai , Karbozova Kunduz , Zholdoshev Emir 
Published: May 2021

AbstractDuring the postictal period, the left cerebral hemisphere was affected by the seizures, and consecutive epileptiform discharges and disinhibition of the right cerebral hemisphere could have occurred, which may explain the observed behavior.
Which immunosuppressive drug is preferred in the treatment of toxic epidermal necrolysis during COVID‐19 outbreak?
Authors: Farajzadeh Saeedeh , Ahramiyanpour Najmeh 
Published: May 2021

AbstractCyclosporine is an effective and safe immunosuppressant in the management of Toxic epidermal necrolysis (TEN) during COVID‐19 outbreak for patients that intravenous immunoglobulin (IVIG) is contraindicated or is not affordable.
Central retinal artery occlusion after catheter ablation of atrial fibrillation
Authors: Matsuda Yasuhiro , Masuda Masaharu , Asai Mitsutoshi , Iida Osamu , Kanda Takashi , Mano Toshiaki 
Published: May 2021

AbstractCentral retinal artery occlusion (CRAO) is a rare but severe and urgent complication of atrial fibrillation ablation. Awareness of this ophthalmologic complication and prompt treatment are needed because ischemic damage to the retina is irreversible from 4 hours after the onset of CRAO.
Prominent hemophagocytosis in cerebrospinal fluid in a patient with pneumococcal meningitis
Authors: Alqasim Alauldeen Mudhafar Zubair , Kariyattil Rajeev 
Published: May 2021

AbstractHemophagocytosis is usually observed in bone marrow. But it can be an incidental finding in other body fluids in severe infections like cerebrospinal fluid in case of meningitis. Clinicians need to rule out primary type of hemophagocytic syndrome.
Penta‐coordinated Al3+ Stabilized Defect‐Rich Ceria on Al2O3 Supported Palladium Catalysts for Lean Methane Oxidation
Authors: Wu Mingwei , Li Wenzhi , Zhang Xia , Xue Fengyang , Yang Tao , Yuan Liang 
Published: May 2021

AbstractIn heterogeneous catalysis, the strong interaction between metal and support can significantly modulate the electronic properties of the metals and play a crucial role in metal particle dispersion and morphology. Herein, a facile strategy was utilized to fabricate highly dispersive palladium catalysts supported on defective Al2O3−CeO2 for lean methane oxidation. Ceria was immobilized on the coordinatively unsaturated Al3+penta sites of γ‐alumina activated by pre‐reduction to fabricate hybrid‐oxide support (abbreviated as RAl2O3−CeO2), and then Pd precursor was uniformly deposited on the defective surface. Such a RAl2O3−CeO2 interface can effectively upgrade the dispersion of deposited palladium species and improve the concentration of reactive oxygen species owing to strong electronic interactions, invoking a superior catalytic activity for lean methane oxidation. After loading 1.0 wt% palladium, Pd/RAl2O3−CeO2 exhibited a 90 % methane conversion at 328 °C under the space velocity of 60,000 mL g−1 h−1, far lower than that of bare 1.0 wt% Pd/RAl2O3 (400 °C). In addition, Pd/RAl2O3−CeO2 catalyst showed an excellent hydrothermal stability under the harsh conditions (600 °C, water vapor)for 120 h without obvious deactivation. The reaction pathway of total methane combustion was elucidated by in situ DRIFTS. The crucial intermediate compositions (carbon oxygenates and carbonate)on Pd/RAl2O3−CeO2 surface are more readily oxidized into CO2 and H2O. This work provides an effective interface‐promoted strategy to develop efficient and durable palladium catalysts for many challenging reactions.
The unsophisticated “sophisticated”: Old age and the accredited investors definition
Authors: Finke Michael , Guo Tao , Huston Sandra 
Published: May 2021

AbstractAccredited investors are able to participate in unregistered securities offerings such as private equity, venture capital, and hedge funds if they meet income and wealth thresholds. This definition provides a simple screening mechanism intended to restrict the purchase of complex securities to investors who are sophisticated enough to “fend for themselves.” We investigate whether older households, who are vulnerable to age‐related cognitive decline and are more likely to meet the accredited investor threshold, possess greater financial sophistication than younger nonaccredited investors. We find strong evidence that older households are at risk of meeting the accredited investor definition without having the sophistication needed to avoid high agency costs in a largely unregulated securities market. Accredited households age 80 and older are more than 80% less likely than unaccredited investors age 60–64 to have high financial sophistication scores. This reduced financial capability in later life appears to mirror the rate of decline in measures of cognition.
Single‐Round DNA Aptamer Selection by Combined Use of Capillary Electrophoresis and Next Generation Sequencing: An Aptaomics Approach for Identifying Unique Functional Protein‐Binding DNA Aptamers
Authors: Saito Shingo , Sakamoto Toshiki , Tanaka Naoki , Watanabe Ryo , Kamimura Takuya , Ota Kazuki , Riley Kathryn R. , Yoshimoto Keitaro , Tasaki‐Handa Yuiko , Shibukawa Masami 
Published: May 2021

AbstractIn DNA aptamer selection, existing methods do not discriminate aptamer sequences based on their binding affinity and function and the reproducibility of the selection is often poor, even for the selection of well‐known aptamers like those that bind the commonly used model protein thrombin. In the present study, a novel single‐round selection method (SR‐CE selection) was developed by combining capillary electrophoresis (CE) with next generation sequencing. Using SR‐CE selection, a successful semi‐quantitative and semi‐comprehensive aptamer selection for thrombin was demonstrated with high reproducibility for the first time. Selection rules based on dissociation equilibria and kinetics were devised to obtain families of analogous sequences. Selected sequences of the same family were shown to bind thrombin with high affinity. Furthermore, data acquired from SR‐CE selection was mined by creating sub‐libraries that were categorized by the functionality of the aptamers (e. g., pre‐organized aptamers versus structure‐induced aptamers). Using this approach, a novel fluorescent molecular recognition sensor for thrombin with nanomolar detection limits was discovered. Thus, in this proof‐of‐concept report, we have demonstrated the potential of a “DNA Aptaomics” approach to systematically design functional aptamers as well as to obtain high affinity aptamers.
(Automated) Synthesis of Well‐defined Staphylococcus Aureus Wall Teichoic Acid Fragments
Authors: Ali Sara , Hendriks Astrid , van Dalen Rob , Bruyning Thomas , Meeuwenoord Nico , Overkleeft Herman S. , Filippov Dmitri V. , van der Marel Gijs A. , van Sorge Nina M. , Codée Jeroen D. C. 
Published: May 2021

AbstractWall teichoic acids (WTAs) are important components of the cell wall of the opportunistic Gram‐positive bacterium Staphylococcus aureus. WTAs are composed of repeating ribitol phosphate (RboP) residues that are decorated with d‐alanine and N‐acetyl‐d‐glucosamine (GlcNAc) modifications, in a seemingly random manner. These WTA‐modifications play an important role in shaping the interactions of WTA with the host immune system. Due to the structural heterogeneity of WTAs, it is impossible to isolate pure and well‐defined WTA molecules from bacterial sources. Therefore, here synthetic chemistry to assemble a broad library of WTA‐fragments, incorporating all possible glycosylation modifications (α‐GlcNAc at the RboP C4; β‐GlcNAc at the RboP C4; β‐GlcNAc at the RboP C3) described for S. aureus WTAs, is reported. DNA‐type chemistry, employing ribitol phosphoramidite building blocks, protected with a dimethoxy trityl group, was used to efficiently generate a library of WTA‐hexamers. Automated solid phase syntheses were used to assemble a WTA‐dodecamer and glycosylated WTA‐hexamer. The synthetic fragments have been fully characterized and diagnostic signals were identified to discriminate the different glycosylation patterns. The different glycosylated WTA‐fragments were used to probe binding of monoclonal antibodies using WTA‐functionalized magnetic beads, revealing the binding specificity of these WTA‐specific antibodies and the importance of the specific location of the GlcNAc modifications on the WTA‐chains.
From classical to supramolecular dynamic stereochemistry: Double crystallization‐induced diastereomerization of thiazine sulfonamide
Authors: Lodochnikova Olga A. , Gerasimova Daria P. , Plemenkov Vitaly V. 
Published: May 2021

AbstractThe interrelation between the configurational lability of nitrogen and sulfur atoms within the –NH–SO2group of some thiazine sulfonamides is discussed. We have found that the compounds of the above series can crystallize as various diastereomers by the nitrogen atom, the relative configuration of the nitrogen atom determining the relative supramolecular configuration of the newly formed chiral sulfur atom. The paper presents a stereochemical transformation, which we have called “double crystallization‐induced diastereomerization.”
Research contributions of Leo A. Behie to chemical and biomedical engineering
Authors: Mehrotra Anil K. , Karan Kunal , Kallos Michael S. , Sen Arindom , Ehsani Sina , Abraham Brett , Roberts Erin L. 
Published: May 2021

AbstractLeo Augustus Behie was known as a dedicated teacher and mentor, a team builder, and an outstanding researcher and innovator. He had a most productive and illustrious career, spanning five decades, that covered both industrial and academic sectors. His academic research career started with tackling classical chemical engineering challenges and, with time, shifted to biotechnology and biomedical engineering. He was the founding director of a unique research laboratory for undertaking innovative biotechnology and biomedical engineering research at the University of Calgary, called the Pharmaceutical Production Research Facility (PPRF). This paper presents an overview of his academic and research accomplishments, which also included the training of 17 doctoral students, 21 master's degree students, and many postdoctoral scholars. His main research areas under the classical chemical engineering theme included the investigation of the grid region in gas–solid fluidized bed reactors; gas–liquid and liquid–solid multiphase systems; fluidized bed reactors for metals recovery from coal ash; spouted fluid‐bed reactors; kinetics of pyrolysis chemical reactions; transport phenomena in rotary drums; and reactions, thermodynamics, and reactor modelling of sulphur systems. His main research areas under the biotechnology and biomedical engineering theme included advances in biotechnology and bioreactor design; production of antibiotic and monoclonal antibody; protein production in insect cells; process development for the production of neural stem cells, cancer stem cells, and islet cells; mesenchymal stem cells; and cellular secretome studies aimed at developing a cure for Parkinson's disease.