bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and User Experiences of a Biopsychosocial Interprofessional Online Course on Persistent Somatic Symptoms
Authors: van Gils A. , Tak L. M. , Sattel H. , Rosmalen J. G. M. 
Published: November 2021

Background: Communication between healthcare providers and patients with persistent somatic symptoms (PSS) is frequently hampered by mutual misunderstanding and dissatisfaction.Methods: We developed an online, interprofessional course to teach healthcare providers the knowledge, skills, and attitude they need to diagnose and treat PSS in a patient-centered manner based on the biopsychosocial model. The course consisted of six modules of 45–60 min. Each module contained different types of assignments, based on six cases: videos, discussion boards, reading assignments, polls, and quizzes. For this study, we included (1) medical residents, following the course as part of their residency training, and (2) healthcare providers (general practitioners, medical specialists, physiotherapists, nurses, and psychologists), following the course as continuing vocational training. Throughout the course, participants were asked to fill out online surveys, enquiring about their learning gains and satisfaction with the course.Results: The biopsychosocial approach was integrated across the modules and teached health care workers about recent insights on biological, psychological and social aspects of PSS. In total, 801 participants with a wide variety in clinical experience started the course; the largest groups of professionals were general practitioners (N = 400), physiotherapists (N = 124) and mental healthcare workers (N = 53). At the start of the course, 22% of the participants rated their level of knowledge on PSS as adequate. At the end of the course, 359 participants completed the evaluation questionnaires. Of this group, 81% rated their level of knowledge on PSS as adequate and 86% felt that following the course increased their competencies in communicating with patients with PSS (N = 359). On a scale from 1 to 10, participants gave the course a mean grade of 7.8 points. Accordingly, 85% stated that they would recommend the course to a colleague.Conclusion: Our course developed in a co-design process involving multiple stakeholders can be implemented, is being used, and is positively evaluated by professionals across a variety of health care settings.
Metastatic Pattern Discriminates Survival Benefit of Type of Surgery in Patients With De Novo Stage IV Breast Cancer Based on SEER Database
Authors: Li Kunlong , Zhou Can , Yu Yan , Niu Ligang , Zhang Wei , Wang Bin , He Jianjun , Ge Guanqun 
Published: November 2021

Background: The role of surgery and surgery type in de novo stage IV breast cancer (BC) is unclear.Methods: We carried out a retrospective cohort study that included the data of 4,108 individuals with de novo stage IV BC abstracted from SEER (Surveillance, Epidemiology, and End Results) data resource from 2010 to 2015. The patients were stratified into the non-surgery group, breast-conserving (BCS) surgery group, and mastectomy group. Inverse probability propensity score weighting (IPTW) was then used to balance clinicopathologic factors. Overall survival (OS), as well as the breast cancer-specific survival (BCSS), was assessed in the three groups using Kaplan–Meier analysis and COX model. Subgroups were stratified by metastatic sites for analysis.Results: Of the 4,108 patients, 48.5% received surgery and were stratified into the BCS group (574 cases) and mastectomy group (1,419 cases). After IPTW balance demographic and clinicopathologic factors, BCS and mastectomy groups had better OS (BCS group: HR, 0.61; 95% CI: 0.49–0.75; mastectomy group: HR, 0.7; 95% CI: 0.63–0.79) and BCSS (BCS group: HR, 0.6; 95% CI, 0.47–0.75; mastectomy group: HR, 0.71; 95% CI, 0.63–0.81) than the non-therapy group. Subgroup analyses revealed that BCS, rather than mastectomy, was linked to better OS (HR, 0.66; 95% CI: 0.48–0.91) and BCSS (HR, 0.63; 95% CI: 0.45–0.89) for patients with bone-only metastasis. For patients with viscera metastasis or bone+viscera metastases, BCS achieved similar OS (viscera metastasis: HR, 1.05; 95% CI: 0.74–1.48; bone+viscera metastases: HR, 1.01; 95% CI: 0.64–1.61) and BCSS (viscera metastasis: HR, 0.94; 95% CI: 0.64–1.38; bone+viscera metastases: HR, 1.06; 95% CI: 0.66–1.73) in contrast with mastectomy.Conclusions: Local surgery for patients with distant metastasis (DS) exhibited a remarkable survival advantage in contrast with non-operative management. BCS may have more survival benefits for patients with de novo stage IV BC with bone-only metastasis than other metastatic sites. Decisions on de novo stage IV BC primary surgery should be tailored to the metastatic pattern.
Recombinant BCG-Prime and DNA-Boost Immunization Confers Mice with Enhanced Protection against Mycobacterium kansasii
Authors: Komine-Aizawa Shihoko , Mizuno Satoru , Matsuo Kazuhiro , Namiki Takahiro , Hayakawa Satoshi , Honda Mitsuo 
Published: November 2021

The incidence of infections with nontuberculous mycobacteria (NTM) has been increasing worldwide. The emergence of multidrug-resistant NTM is a serious clinical concern, and a vaccine for NTM has not yet been developed. We previously developed a new recombinant Bacillus Calmette–Guérin (rBCG) vaccine encoding the antigen 85B (Ag85B) protein of Mycobacterium kansasii—termed rBCG-Mkan85B—which was used together with a booster immunization with plasmid DNA expressing the same M. kansasii Ag85B gene (DNA-Mkan85B). We reported that rBCG-Mkan85B/DNA-Mkan85B prime–boost immunization elicited various NTM strain-specific CD4+ and CD8+ T cells and induced Mycobacterium tuberculosis-specific immunity. In this study, to investigate the protective effect against M. kansasii infection, we challenged mice vaccinated with a rBCG-Mkan85B or rBCG-Mkan85B/DNA-Mkan85B prime–boost strategy with virulent M. kansasii. Although BCG and rBCG-Mkan85B immunization each suppressed the growth of M. kansasii in the mouse lungs, the rBCG-Mkan85B/DNA-Mkan85B prime–boost vaccination reduced the bacterial burden more significantly. Moreover, the rBCG-Mkan85B/DNA-Mkan85B prime–boost vaccination induced antigen-specific CD4+ and CD8+ T cells. Our data suggest that rBCG-Mkan85B/DNA-Mkan85B prime–boost vaccination effectively enhances antigen-specific T cells. Our novel rBCG could be a potential alternative to clinical BCG for preventing various NTM infections.
Del conventillo a la vivienda higiénica. Espacio doméstico, ciudad e instituciones en Santiago de Chile. 1890-1940
Authors: BONOMO Umberto , MONDRAGÓN Hugo 
Published: November 2021

El aumento de la población de Santiago a fines del siglo XIX, agudizó los problemas de salubridad e higiene en las viviendas de los sectores vulnerables. A comienzos del siglo XX, comenzó a intervenir el Estado, quien promulgó la Ley de Habitaciones Baratas y creó un conjunto de Cajas de Previsión Social, que acudieron a parámetros estéticos de la arquitectura racionalista para solucionar la falta de ventilación e iluminación en las viviendas. A través de publicaciones periódicas especializadas, arquitectos y urbanistas se integraron al debate en los años '30. Imbuidos por un espíritu nacionalista y reformista, enfocaron el problema en el campo de la indignación y malestar social. Sin embargo, en los ’40 el enfoque cambia hacia la estadística. Así, las soluciones se situaron en el terreno de la ingeniería social, que se reflejó en la formulación del primer Plan de la Vivienda en 1953. Palabras clave: Santiago – salubridad – Política estatal – publicaciones periódicas.
La arqueología y el estudio del conflicto armado en contextos prehistóricose históricos: un estado de la cuestión
Authors: Leoni Juan B. 
Published: November 2021

El estudio de la guerra y hechos de violencia grupal de distintos tipos y escalas ha experimentado un enorme crecimiento en la arqueología contemporánea. Aunque se los suele incluir bajo la denominación genérica de Arqueología del Conflicto, la misma dista mucho de constituir un campo unificado programáticamente. Por el contrario, existen varios subcampos que se diferencian notoriamente entre sí, siendo la división fundamental la determinada por el estudio de casos prehistóricos o históricos. El tipo de información disponible es lo que determina las diferencias en el abordaje teórico-metodológico, en el primer caso vinculándose con la antropología mientras que en el segundo se acerca más a la historia militar. En este trabajo se pasa revista al desarrollo de la Arqueología del Conflicto, recapitulando las principales posturas antropológicas en relación al estudio de la guerra, el estudio arqueológico de conflictos prehistóricos y la arqueología histórica de campos de batalla, así como proponiendo formas de lograr una mayor integración entre estos distintos campos disciplinares. Palabras clave: Arqueología del Conflicto; guerra; campos de batalla; indicadores arqueológicos
El poder de la guerra: ¿Es posible hablar de "Cultura de la Guerra" en el Cercano Oriente Antiguo?
Authors: Nadali Davide 
Published: November 2021

Este estudio realiza una consideración sobre la importancia social y el rol que la guerra tuvo en las sociedades del Cercano Oriente antiguo desde los tiempos más antiguos. Existen evidencias visuales y textuales que describen, conmemoran y narran los eventos bélicos desde el IV milenio a.C. pero la naturaleza de esos documentos ha sido sobreestimada y malinterpretada. El estudio se inicia con una definición de “cultura de la guerra” e intenta señalar cómo la guerra estaba socialmente imbricada como una operación política y cultural por sobre y más allá de los límites de las interpretaciones ideológicas y propagandísticas que han siso sugeridas en el pasado. Palabras clave: Mesopotamia; realeza; guerra; ideología; propaganda
Estudio de las alteraciones de la agregación eritrocitaria en pacientes con accidente cerebrovascular isquémico.
Authors: Capriotti Corrente Jorge , Svetaz María J. , Urli Leda , Raimondi Elsa , Luquita Alejandra 
Published: November 2021

El accidente cerebrovascular (ACV) isquémico es causado por evolución de procesos aterotrombóticos que se relacionan con daño y disfunción endotelial debido a patologías crónicas como hipertensión arterial y dislipemia. En trabajos previos se ha informado sobre alteraciones hemorreológicas en el curso de la patología vascular cerebral, en particular el incremento en la agregación eritrocitaria (AE). El presente trabajo tiene como objetivo principal estudiar las modificaciones de las propiedades hemorreológicas y en particular de la AE, en 20 pacientes con ACV isquémico durante la etapa aguda, en comparación a un grupo control (n = 20) con similares factores de riesgo. Se determinó en plasma: concentración de fibrinógeno, proteína C reactiva y triglicéridos. En sangre: agregación eritrocitaria por densitometría óptica, obteniéndose el tamaño promedio de los agregados y la velocidad inicial del proceso, velocidad de eritrosedimentación, índice de rigidez eritrocitaria, viscosidad sanguínea, viscosidad plasmática y viscosidad sanguínea relativa estandarizada a un hematocrito del 45%. Se encontró que los eritrocitos de los pacientes con ACV agregaron a mayor velocidad (0,92 ± 0,64 vs 0,49 ± 0,24; p < 0,00001) y formaron agregados de mayor tamaño (1,84 ± 0,07 vs 1,81 ± 0,07; p<0,05) que los controles. Este fenómeno correlacionó (r: coeficiente de Pearson) con las alteraciones encontradas en el plasma, en particular con las concentraciones séricas de fibrinógeno (r = 0,565; p <0,01) y triglicéridos (r = 0,693; p <0,001). La identificación de estos factores es de relevancia clínica ya que podría tener incidencia en las estrategias terapéuticas.
Pengaruh Penerimaan Daerah Terhadap Belanja Langsung Dengan Variabel Pemoderasi Produk Domestik Regional Bruto Provinsi Lampung
Authors: Ayu Septiawati  , Yuliana Sari  , Sopiyan A.R  , Periansya  
Published: November 2021

Otonomi daerah mendorong tingkat kemandirian keuangan daerah dalam mendanai Belanja Langsung agar tercapainya standar pelayanan publik dan pemerataan pembangunan. Tujuan penelitian ini guna membuktikan pengaruh pemoderasi PAD,DAU,DAK dan PDRB terhadap Belanja Langsung. Metode pengujian penelitian menggunakan teknik analisis regresi moderasi (MRA) melalui uji interaksi dengan sampel penelitian pada Laporan Keuangan Pemerintah Daerah di 15 Kabupaten/Kota periode 2016-2020. Hasil pengujian bahwa PAD, DAK, dan PDRB menunjukkan pengaruh positif dan signifikan secara parsial, sedangkan DAU sebaliknya atas Belanja Langsung. PAD, DAU, DAK, dan PDRB memiliki pengaruh simultan dengan signifikansi sebesar 71,1%. Hasil uji moderasi bahwa PDRB secara parsial tidak dapat memoderasi sedangkan secara bersamaan dipengaruhi variabel moderating memiliki pengaruh simultan dengan signifikasi sebesar 72,8%. Kesimpulan dari penelitian ini diperlukannya faktor moderasi untuk meningkatkan Belanja Langsung selain itu pemerintah daerah agar kedepannya melibatkan pihak swasta dalam menggali potensi penerimaan daerah yang lebih optimal.
Pengaruh Bauran Promosi terhadap keputusan Pelanggan Menggunakan jasa PT. Pos Indonesia Cabang Soreang
Authors: Hana Aulia Soleha  , Prihartono Aksan Halim  
Published: November 2021

Tujuan penelitian ini untuk mengetahui seberapa besar pengaruh Bauran Promosi yang terdiri dari variabel , advertising (X1), personal selling(X2), public relations (X3), sales promotion(X4), direct marketing (X5) terhadap Keputusan Pelanggan menggunakan jasa Pos Indonesia Soreang. Berdasarkan hasil perhitungan didapat dengan hasil persamaan regresi linier Y= 11,278 + 0,463X1 +0,746X2 + (-0,678)X3 + 1,258X4 + 0,927X5. Hasil penelitian ini menunjukan bahwa secara secara simultan variabel advertising, personal selling, public relations, sales promotion, directs marketing berpengaruh signifikan terhadap variabel keputusan pelanggan. Secara parsial variabel personal selling (X2) dan sales promotion (X4) berpengaruh positif dan signifikan dengan thitung 2.033 dan 2.741 > t tabel 2,00958, kemudian variabel advertising(X1) dan direct marketing (X5) berpengaruh positif dan tidak signifikan dengan thitung 1,538 dan 1.813 < t tabel 2,00958, serta pada variabel public relations(X5) berpengaruh negatif dan tidak signifikan dengan thitung -1.212 < t tabel 2,00958 terhadap variabel keputusan pelanggan
Taurid Stream #628: A Reservoir of Large Cometary Impactors
Authors: Devillepoix Hadrien A. R. , Jenniskens Peter , Bland Philip A. , Sansom Eleanor K. , Towner Martin C. , Shober Patrick , Cupák Martin , Howie Robert M. , Hartig Benjamin A. D. , Anderson Seamus , Jansen-Sturgeon Trent , Albers Jim 
Published: November 2021

Abstract
The Desert Fireball Network observed a significant outburst of fireballs belonging to the Southern Taurid Complex of meteor showers between 2015 October 27 and November 17. At the same time, the Cameras for Allsky Meteor Surveillance project detected a distinct population of smaller meteors belonging to the irregular IAU shower #628, the s-Taurids. While this returning outburst was predicted and observed in previous work, the reason for this stream is not yet understood. 2015 was the first year that the stream was precisely observed, providing an opportunity to better understand its nature. We analyze the orbital elements of stream members and establish a size–frequency distribution from millimeter to meter size range. The stream is highly stratified with a large change of entry speed along Earth’s orbit. We confirm that the meteoroids have orbital periods near the 7:2 mean motion resonance with Jupiter. The mass distribution of this population is dominated by larger meteoroids, unlike that for the regular Southern Taurid shower. The distribution index is consistent with a gentle collisional fragmentation of weak material. A population of meter-sized objects is identified from satellite observations at a rate consistent with a continuation of the size–frequency distribution established at centimeter size. The observed change of longitude of perihelion among the s-Taurids points to recent (a few centuries ago) activity from fragmentation involving surviving asteroid 2015 TX24. This supports a model for the Taurid Complex showers that involves an ongoing fragmentation cascade of comet 2P/Encke siblings following a breakup some 20,000 yr ago.
Thermal and Tidal Evolution of Uranus with a Growing Frozen Core
Authors: Stixrude Lars , Baroni Stefano , Grasselli Federico 
Published: November 2021

Abstract
The origin of the very low luminosity of Uranus is unknown, as is the source of the internal tidal dissipation required by the orbits of the Uranian moons. Models of the interior of Uranus often assume that it is inviscid throughout, but recent experiments show that this assumption may not be justified; most of the interior of Uranus lies below the freezing temperature of H2O. We find that the stable solid phase of H2O, which is superionic, has a large viscosity controlled by the crystalline oxygen sublattice. We examine the consequences of finite viscosity by combining ab initio determinations of the thermal conductivity and other material properties of superionic H2O with a thermal evolution model that accounts for heat trapped in the growing frozen core. The high viscosity provides a means of trapping heat in the deep interior while also providing a source of tidal dissipation. The frozen core grows with time because its outer boundary is governed by the freezing transition rather than compositional layering. We find that the presence of a growing frozen core explains the anomalously low heat flow of Uranus. Our thermal evolution model also predicts time-varying tidal dissipation that matches the requirements of the orbits of Miranda, Ariel, and Umbriel. We make predictions that are testable by future space missions, including the tidal Love number of Uranus and the current recessional rates of its moons.
Evaluation of Extreme Hip Joint Movement after Total Hip Arthroplasty: A Retrospective Study
Authors: Anwar Iwan Budiwan , Van der Heide Emile , Jamari J. , Saputra Eko , Santoso Asep , Adriansyah Denny , Arimukti Zarkasyi 
Published: November 2021

Introductions: The number of total hip arthroplasty (THA) is increased every year in our country. Mobility ofthe hip joint after THA is important to achieve. Subject’s expectation to perform daily activity, moreoverextreme hip movement are crucial for some particular populations. This study aimed to evaluate patient’s functional outcome and ability to peform extreme hip joint movement. Methods: This is a retrospective study of patients who received total hip arthroplasty in our center. Evaluated factors Include age, gender, body mass Index (BMI), socio-economic status, diagnosis, physical therapy, radiographic acetabular inclination, acetabular cup diameter, and head diameter. Clinical evaluation performed with Harris hip score (HHS). Extreme hip joint movement evaluation performed with patient’s ability to perform squatting and Salat (Muslim prayer). The chi-square and mann-whitney tests were used for data analysis. Results: We collected data from a total of 22 subjects. All patients (100%) could perform squatting postoperatively. Among the subjects, therewere 11 patients (11/22, 50%) could perform Salat activity in excellent manner, while the rest (11 patients)need some modification of movement during Salat activity. All patients have significant improvement of Harris hip score compared to preoperative condition. Further, we tried to compare factors between the two group for possible difference. No significant difference in age, gender, BMI, comorbidities, preoperative diagnosis between two group of patients. Conclusions: Subject receiving THA can be expected to perform extreme hip joint movement post-operatively. However, some patients still could not perform Salat activity in excellent manner. Age, gender, BMI, and comorbidities seem to be had no effect on the patient’s ability to performextreme hip movement post-operatively.
The contribution of authors from low- and middle-income countries to top-tier mental health journals
Authors: El Khoury Joseph , Kanj Riwa , Adam Lynn , Kanj Rama , Hajaig Abdul Jalil , Haddad Firas , El Helou Rita Christie 
Published: November 2021

Background:&nbsp;Low- and middle-income countries (LMICs) have been consistently under-represented in the pool of contributors&nbsp;to academic journals on health. For the past two decades, prominent voices within the psychiatric profession have called for better&nbsp;representation of LMICs in the interest of advancing the understanding of mental health globally and benefiting health systems&nbsp;in these countries.
Objective:&nbsp;To investigate the absolute and relative representation of authors affiliated to institutes from LMICs in the most&nbsp;influential journals on mental health in 2019.
Method:&nbsp;Thirty top-ranking journals on mental health based on Scimago Journal Rank were selected, and all papers other than&nbsp;correspondence and letters to the editor published in those journals in 2019 were examined to extract the country of affiliation of&nbsp;each of their authors and their position (corresponding author, first author, second author).
Results:&nbsp;Of the 4022 articles examined, 3720 articles (92.5%) were written exclusively by authors from high-income countries&nbsp;(HICs); 302 (7.5%) featured one or more authors from a LMIC along with those from HICs; 91 (2.2%) featured authors only from&nbsp;one LMIC; and only 3 (0.07%) featured authors from more than one LMICs but without any co-author from a HIC. The ratio&nbsp;of articles by contributors from LMICs to all the articles published in 2019 in a given journal ranged from 0% to 19%. Of 1855&nbsp;individual contributors from 45 LMICs, 1050 (56%) were from China.
Conclusion:&nbsp;Despite the growth of the global health movement and frequent calls for academic inclusivity, LMICs were significantly&nbsp;under-represented among the authors of papers published in top-ranking journals on mental health in 2019.
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La estela de Q. Palma: una nueva y singular inscripción funeraria de la Colonia Augusta Firma Astigi (Écija, Sevilla)
Authors: Fernández Ugalde Antonio 
Published: November 2021

Nueva estela romana con cabecera semicircular aparecida a las afueras de la Colonia Augusta Firma Astigi (Écija, Sevilla), que presenta una inscripción con ciertas singularidades y con la primera mención en la península ibérica del cognomen Palma.
The Hippocratic clubfoot re-visited
Authors: Graumann Lutz Alexander 
Published: November 2021

The Hippocratic treatise On Joints contains a careful description of the clubfoot, its causes and its rehabilitation. Galen of Pergamum has extensively commented on this passage. More than fifty years ago Markwart Michler devoted a large study on the Hippocratic theory of the clubfoot. It is now time for an innovative, critical reappraisal of this topic in the light of recent research on these ancient medical writings and on their proposed relation to today's medical practice. It will be shown that both the ancient and the modern concept of clubfoot differ in many aspects. That renders comparison nearly impossible, or at least more difficult, bearing also in mind the now experienced historicity of Michler’s work itself.
Hippocrate inventeur de la clinique et les médecins clinicoi
Authors: Boudon-Millot Véronique 
Published: November 2021

Ce chapitre a pour but d’attirer l’attention sur un paradoxe : alors qu’Hippocrate est universellement reconnu comme le père de la médecine clinique basée sur l’observation de signes cliniques et sur des conclusions rationnelles, on ne trouve nulle part dans tout le Corpus hippocratique l’adjectif grec clinicos. De fait, la première occurrence de ce mot se trouve en latin, chez Pline l’Ancien, où l’adjectif clinice sert précisément à qualifier la médecine dite clinique inventée par Hippocrate. L’étude se concentre d’abord sur les deux seuls médecins qualifiés de clinicoi dans le Corpus galénique, Damocrate et Magnos, en s’attachant ensuite à définir l’activité exacte de ces médecins et, pour finir, ce que les médecins de l’époque impériale entendaient par médecine clinique.