bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of High-Dose Radioactive Iodine Treatment On Renal Function In Patients With Differentiated Thyroid Carcinoma: A Retrospective Study
Authors: Yin Liang , Li Weilong , Wang Yan , Lin Yangyang , Lin Zhichun , Jia Qiang , Tan Jian , Li Xue , Guo Qing , Meng Zhaowei 
Published: July 2021

Abstract
Aim: This study aimed to investigate the effects of high-dose radioactive iodine (131I) treatment on the clinical metrics of renal function in patients with differentiated thyroid carcinoma (DTC).Patients and methods: The clinical metrics of renal function were analysed in 850 patients with DTC who received 131I therapy between January 2012 and December 2019. According to the baseline renal function metrics, the patients were divided into normal renal function group (group A) and abnormal renal function group (group B). Each group was further divided into three subgroups (subgroups 1, 2, and 3) based on the cumulative dose of 131I. The clinical metrics of renal function including serum creatinine (SCr) levels, blood urea nitrogen (BUN) levels and estimated glomerular filtration rate (eGFR) were measured within 1 month before the initiation of 131I therapy, 1 year after the last therapy, and 5 years after the initial therapy. The changes in renal function metrics before and after 131I therapy were compared in each group.Result: In group A (588 patients), no significant difference in the mean levels of SCr and BUN and eGFR was observed in the three subgroups (P >0.05), regardless of gender, before the initial 131I therapy and 1 year after the last therapy. A total of 8, 3, and 2 patients presented with abnormal renal function after 131I treatment in subgroups 1, 2, and 3, respectively. No statistically significant difference was observed in the incidence of renal dysfunction among the three subgroups (P = 0.287). The mean age of patients with renal dysfunction was significantly greater than that of patients without renal dysfunction after 131I treatment. In group B, of the 262 patients with abnormal renal function, SCr and BUN levels were elevated in 168 and 155 patients, respectively, and eGFR <60 mL/min/1.73 m2 was found in 87 patients before the initial 131I therapy. No significant difference was observed in the parameters among the three subgroups. However, SCr and BUN levels were found to be increased in all subgroups 5 years after the initial 131I therapy, and they were positively correlated with the cumulative dose of 131I. The difference was statistically significant (P <0.05). Furthermore, eGFR was found to be decreased in all subgroups after 131I therapy, and it was negatively correlated with the cumulative dose of 131I. The difference was statistically significant (P <0.05). A gender bias was not observed in the changing trends of SCr and BUN levels and eGFR.Conclusion: Our findings suggest that the nephrotoxicity of high-dose 131I therapy, regardless of gender, is very low in patients with DTC with normal renal function; however, high-dose 131I therapy may exacerbate the loss of renal function in those with renal dysfunction.
Visual Feedback Improves Bimanual Force Control Performances at Planning and Execution Levels
Authors: Kim Hyun Joon , Lee Joon Ho , Kang Nyeonju , Cauraugh James H. 
Published: July 2021

Abstract
The purpose of this study was to determine whether altered interlimb coordination patterns across trials improved bimanual force control capabilities within a trial. Fourteen healthy young participants completed bimanual force control tasks at 5%, 25%, and 50% of maximum voluntary contraction with and without visual feedback. To estimate synergetic coordination patterns between hands across multiple trials, we analyzed our primary outcome measure by performing an uncontrolled manifold analysis. In addition, we calculated force accuracy, variability, and regularity within a trial to quantify task stabilization. Using Pearson’s correlation analyses, we determined the relation between the changes in bilateral motor synergies (i.e., a proportion of good variability relative to bad variability) and bimanual force control performance from no-vision to vision conditions. The findings revealed that the presence of visual feedback significantly increased bilateral motor synergies with a reduction of bad variability components across multiple trials, and decreased force error, variability, and regularity within a trial. Further, we observed significant positive correlations between higher bilateral motor synergies and increased improvements in force control capabilities. These findings suggested that bimanual synergetic coordination behaviors at the planning level modulated by external sensory feedback may be related to advanced task stabilization patterns at the execution level.
Predictive ability of the Mini Nutritional Assessment short-form (MNA-SF) as compared to serum albumin concentration in the community dwelling elders, Meki, East Ethiopia
Authors: Urgessa Megersso 
Published: July 2021

Abstract
Background: Different tools have been used to perform a nutritional screening and assessment, and MNA is one of the widely used and recommended tools in the geriatrics population. MNA has two forms, long and short. However, MNA short-forms have not been evaluated in Ethiopia. Therefore, this study was aimed to evaluate MNA short form against serum albumin concentration among Ethiopian elders.Methods: One hundred and seventy-six randomly selected elders entered into the community-based cross-sectional validation study. Amputated, bedridden, those with visible deformity were excluded. Original MNA questionnaires were translated to Afan Oromo and Amharic languages. All translated and pretested MNA questionnaires were administered to each participant. The anthropometrics and serum albumin concentration were measured. Reliability, validity, sensitivity, specificity, positive and negative predictive values were calculated. Receiver-operating characteristic curve (ROC-curve) analysis was plotted for MNA, to identify the area under the curve (AUC) and optimal cut-off value for prediction of malnutrition.Result: Strong association between serum albumin concentration score and MNA-short form score indicated by spearman’s rank correlation coefficients of BMI-MNA-SF 0.526,p <0.05 and CC-MNA-SF 0.501, P<0.05. Similar the agreement between the long and short form of MNA was found to be a weighted kappa 0.404(0.288, 0.521) for BMI-MNA-SF and 0.426(0.333, 0.519) for CC-MNA-SF at 95% CI. These values indicate moderate agreement with the serum albumin concentration. There is very good agreement between the BMI-MNA-SF and CC-MNA-SF 0.400(0.322, 0.478). Also, high power to identify two categories using serum albumin concentration as golden standard with AUC for BMI –MNA-SF 0.789 (0.722-0.855) and 0.791 (0.726-0.857) for CC-MNA-SF at 95% CI. Diagnostic accuracy for BMI-MNA-SF showed that 37.1% sensitivity, 90.8% specificity, 58.5% PPV, and 80.5% NPV. Similar sensitivity 77.5%, specificity of 64.4% PPV 73.7%, and 69.0%, NPV for CC-MNA-SF. Total Diagnostic accuracy for BMI-MNA-SF 63.64%, and 71.02% for CC-MNA-SF.Conclusion: Both versions of MNA-SF were found to be valid screening tools in the Ethiopian elders against serum albumin concentration.
Wnt6 Plays a Complex Role in Maintaining Human Limbal Stem/Progenitor Cells
Authors: Bonnet Clémence , Oh Denise , Mei Hua , Robertson Sarah , Chang Derek , Bourges Jean-Louis , Behar-Cohen Francine , Deng Sophie X. , Zheng Jie J. 
Published: July 2021

Abstract
The cornea is consistently regenerated by limbal stem/progenitor cells (LSCs), a very small population of adult stem cells residing in the limbus. Several Wnt ligands, including Wnt6, are preferentially expressed in the limbus. To investigate the role of Wnt6 in regulating proliferation and maintenance of human LSCs in an in vitro LSC expansion setting, we generated NIH-3T3 feeder cells to overexpress different levels of Wnt6. Characterization of LSCs cultured on Wnt6 expressing 3T3 cells showed that high levels of Wnt6 increased proliferation of LSCs. Medium and high levels of Wnt6 also increased the percentage of small cells (diameter ≤ 12 µm), a feature of the stem cell population. Additionally, the percentage of cells expressing the differentiation marker K12 was significantly reduced in the presence of medium and high Wnt6 levels. Although Wnt6 is mostly known as a canonical Wnt ligand, our data showed that canonical and non-canonical Wnt signaling pathways were activated in the Wnt6-supplemented LSC cultures, a finding suggesting that interrelationships between both pathways are required for LSC regulation.
Apoptosis Inducible Factor P53 Decrease Glutamate-Associated Damage via Inhibiting Ferroptosis
Authors: Yang Zeyong , Xuan Wenting , Jin Yaru , Li Yuanhai 
Published: July 2021

Abstract
BACKGROUND: Ferroptosis, a pattern of programmed cell death decided by iron-associated lipid peroxidation, however, its role of p53-mediated xCT pathway in HT22 cell death remains obscure. Herein, this study is to investigate the potential mechanism of the effect of p53-mediated xCT pathway in HT22 cell lines in an iron-relevant mode. METHODS: The viability of HT22 cells were detected by Cell Counting Kit-8(CCK-8) and PI/Hoechst fluorescence double staining. The protein expression levels of p53 and xCT were determined by western boltting. DHE fluorescence staining technique supervised the intracellular reactive oxygen species (ROS), and intracellular lipid oxidant situation was confirmed by BODIPY 581/591 C11 lipid peroxidation sensor. Intracellular ferrous ions were monitored with FeRhoNox™-1 fluoresceent probe. RESULTS: The protein expression levels of p53 was obviously enhanced by tenovin-1 exposure. Accompanied with the upregulation of p53 protein, cell death was decreased significantly because of glutamate and erastin exposure with 8h, and p53-mediated xCT pathway was activated. Intracelluar ROS levels, lipid oxidant situations and ferrous ions were remarkably restricted from Glutamate-p53 groups in comparison with glutamate groups. CONCLUSIONS: Overall, P53-mediated xCT pathway could decrease the glutamate-associated neurotoxicity, which may be relevant to the inhibition of ferroptosis.
Tool Wear Prediction Based on Multidomain Feature Fusion by Attention-Based Depth-Wise Separable Convolutional Neural Network in Manufacturing
Authors: Li Guofa , Wang Yanbo , He Jialong , Huo Yongchao 
Published: July 2021

Abstract
Tool wear during machining has a great influence on the quality of machined surface and dimensional accuracy. Tool wear monitoring is extremely important to improve machining efficiency and workpiece quality. Multidomain features (time domain, frequency domain and time-frequency domain) can accurately characterise the degree of tool wear. However, manual feature fusion is time consuming and prevents the improvement of monitoring accuracy. A new tool wear prediction method based on multidomain feature fusion by attention-based depth-wise separable convolutional neural network is proposed to solve these problems. In this method, multidomain features of cutting force and vibration signals are extracted and recombined into feature tensors. The proposed hypercomplex position encoding and high dimensional self-attention mechanism are used to calculate the new representation of input feature tensor, which emphasizes the tool wear sensitive information and suppresses large area background noise. The designed depth-wise separable convolutional neural network is used to adaptively extract high-level features that can characterize tool wear from the new representation, and the tool wear is predicted automatically. The proposed method is verified on three sets of tool run-to-failure data sets of three-flute ball nose cemented carbide tool in machining centre. Experimental results show that the prediction accuracy of the proposed method is remarkably higher than other state-of-art methods. Therefore, the proposed tool wear prediction method is beneficial to improve the prediction accuracy and provide effective guidance for decision making in processing.
A Novel miRNA Y-56 Mediates the Proliferation of Porcine Skeletal Muscle Satellite Cells by Targeting the IGF-1R-mediated AKT and ERK Pathways
Authors: Song Jie , Hao Linlin , Zeng Xiangfang , Yang Rui , Qiao Shiyan , Wang Chunli , Yu Hao , Wang Siyao , Jiao Yingying , Jia Hongyao , Liu Songcai 
Published: July 2021

Abstract
Background: The skeletal muscle phenotype of the Bama Xiang pig (BM) is significantly different from the Landrace pig (LP). Uncovering the mechanism of porcine skeletal muscle growth will be of great significance to elucidate the mechanism of the different formation. As the key post-transcriptional regulators, miRNAs play an indispensable role in skeletal muscle development. The proliferation of skeletal muscle satellite cells not only maintain the muscle stem cell population, but also provide a large number of muscle derived cells. Thus, the goal of this study is to explore the effects of a novel miRNA Y-56 on the porcine skeletal muscle satellite cells (PSCs). Results: Firstly, we found that Y-56 was highly expressed in porcine muscle tissues, and its expression was higher in the BM than the LP. The EdU staining and CCK-8 assays results showed that increased levels of Y-56 suppressed cell proliferation, whereas decreased levels of Y-56 resulted in the opposite consequences. Furthermore, flow cytometry results showed that overexpression of Y-56 significantly reduced the percentage of S-phase cells, and the qRT-PCR and western blotting results showed that the expression levels of cyclin dependent kinase 2 (CDK4), proliferating cell nuclear antigen (PCNA) and Cyclin D1 were significantly inhibited. Moreover, downregulation of Y-56 increased the number of S-phase cells and the expression of CDK, PCNA and Cyclin D1. Furtherly, we identified that insulin like growth factor-1 receptor (IGF-1R) was a direct target of Y-56. Consistently, overexpression of IGF-1R promoted the cell proliferation of the PSCs, and increased the number of S-phase cells, as well as up-regulated the expressions of CDK4, PCNA and Cyclin D1. Meanwhile, knock-down of IGF-1R was associated with the opposite tend. What’s more, overexpression of IGF-1R partially reversed the inhibition of cell proliferation of the PSCs, the decrease of the percentage of S-phase cells and down-regulation of the expression levels of CDK4, PCNA and Cyclin D1, which caused by overexpression of Y-56. Finally, there was a significant decrease in the expression level of p-AKT and p-ERK with transfecting Y-56 mimics in the PSCs, and overexpression of IGF-1R reversed the decrease. Conclusion: Collectively, our findings suggested that Y-56 represses proliferation and cell cycle process of the PSCs through targeting IGF-1R that activated the AKT and ERK pathways.
Molecular Insights Into the Genetic Diversity and Population Structure of Artemisia Annua L. As Revealed by Insertional Polymorphisms
Authors: Valizadeh Negar , Holasou Hossein Abbasi , Mohammadi Seyyed Abolghasem , Khawar Khalid Mahmood 
Published: July 2021

Abstract
BackgroundRetrotransposons-RTNs, are main source of variations in plant genomes that copying and pasting themselves into different transposon and work by changing RNA back into DNA via reverse transcription. For that reason, they are largely utilized in plants as optimum molecular markers to determine DNA fingerprinting, genetic mapping, and genetic variability. ResultsInter-retrotransposon amplified polymorphisms (IRAPs) were used to measure genetic variability and structure in a collection of 118 sweet wormwood (A. annua) accessions identifying and amplifying 849 loci using 32 IRAP primers, derived from Rosaceae, Gramineae, and Solanaceae retroelements. Single IRAP primer Tnt1.OL16 based on RTN produced the maximum count of markers. Percentage of polymorphic loci (PPL), mean expected heterozygosity (He), number of effective alleles (Ne) and information index (I) of Shannon, in the studied collection were 95.80%, 0.30, 1.48 and 0.46, in the same order. AMOVA analysis showed nonexistence of significant genetic structures during structure analysis, however, the 4 populations had three clusters based on the NJ dendrogram that depicted a relatively higher level of genetic variation within each population. These clusters were approximately congruent with corresponding geographical distributions. ConclusionsIn conclusion, low genetic diversity of Iranian Sweet wormwood was detected that could be reduced through introduction of appropriate exotic or improved germplasm to reduce the effects of inbreeding depression.
Two Weeks High Glucose is Enough to Induce Liver and Gut Lesion
Authors: Min Cunyun , Fu Tingting , Du Yu , Tan Wei , Huang Xiuhui , Zhan Feng 
Published: July 2021

Abstract
Background: High glucose is critical for diabetes.But in which way it induces diabetes, and which organ trigger the formation of diabetes are not clear.This study is to evaluate the effect of shot time high glucose on different organs,to make clear this question.Methods: Twelve weeks old SD rats were randomly assigned to control group,high glucose infusion (HGI) group and oral high glucose (OHG) group.Fasten blood sugar,TNF-a and IL-6 were measured.Kidneys,intestine and liver samples were collected for pathological examination.Feces of rats were collected for gut microbiota tests.Results: The results indicated that short time high glucose induced hyperglycemia lasted for at least 2 weeks after ceasing of high glucose.It increased serum levels of IL-6 and TNF-a obviously.It led to small intestinal mucosa injury, obvious steatosis of hepatocytes, and broke the balance of gut microbiota.OHG led to swelling and necrosis of individual intestinal villi.HGI led to necrosis and disappearence of cells in the upper layer of intestinal mucosa.The lesion was confined to the mucosa.There is not obvious biopsy change in kidney and pancreas.Conclusions: Short time high glucose induced lesion of liver and intestine,broken the balance of gut microbiota.All of these led to inflammation and triggered diabetes.
An IoT Fast and Low Cost Based Smart Irrigation Intelligent System Using a Fuzzy Energy-Aware Routing Approach
Authors: Rezaeipanah Amin 
Published: July 2021

Abstract
Agriculture plays a major role in the world economy and most people depend on it for their livelihood. This makes water an important resource that must be conserved using the latest available technologies. Today, the Internet of Things (IoT) has extended its capabilities to smart farming. In this paper, an automated and low-cost system for intelligent irrigation based on a Fuzzy-based energy-aware routing approach is presented. In addition, a neural network is trained to determine the best irrigation program, based on information received from sensors (such as temperature, soil moisture, etc.). The user in the system can monitor the data collection process with mobile phones, mobile computers, etc. and manage the irrigation of agricultural products. The proposed system proves its suitability with intelligence and low cost and portability, for greenhouses, farms, etc. The simulation results show that the proposed method offers better results compared to the LEACH protocol as well as the WSN-IoT algorithm in various criteria such as network lifetime and power consumption.
Clinical features and treatment of spinal metastatic pheochromocytoma and paraganglioma: a single institutional experience with 18 patients
Authors: Du Suiyong , Hu Panpan , Yang Shaomin , Zhuang Hongqing , Wei Feng , Liu Xiaoguang , Liu Zhongjun 
Published: July 2021

Abstract
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors, which can potentially metastasize to the spine. Clinical researches and treatment guideline on this entity are lacking. This study described the clinical features and treatment outcomes of metastatic PPGLs on the spine. We reviewed 18 patients with spinal PPGLs who were consecutively treated in our spinal center. The cohort included ten cases of pheochromocytomas and eight paragangliomas. The local pain and neurological deficits were the two most common symptoms. One third of the spinal PPGLs were diagnosed as functional tumors. The surgical strategies for the cohort included percutaneous vertebroplasty, neurological decompression and partial tumor resection with or without internal fixation, and total en-bloc resection. The postoperative courses were uneventful except one patient developed heart failure. The adjuvant therapies were implemented in six patients with 131I-MIBG, five with radiotherapy, two with chemotherapy and one with target therapy. The median survival period was 39 months. The patients’ Karnofsky performance scores were positively correlated with the overall survival (p < 0.05).Therefore, surgery is indicated for intractable local pain and neurological impairment in the patients with spinal PPGLs, while a holistic set of adjuvant therapies shall be incorporated for a better tumor control.
Systematic Review and Meta-Analysis: What is the Prevalence of Non-Malignant, Organic Gastrointestinal Disorders Misdiagnosed as Lrritable Bowel Syndrome?
Authors: Poon Dennis , Law Graham , Major Giles , Andreyev H. 
Published: July 2021

Abstract
IntroductionTreatable gastrointestinal disorders in patients with symptoms typical for irritable bowel syndrome (IBS) may be overlooked. The prevalence of five gastrointestinal conditions - bile acid diarrhoea (BAD), carbohydrate malabsorption (CM), microscopic colitis (MC), pancreatic exocrine insufficiency (PEI) and small intestinal bacterial overgrowth (SIBO) was systematically assessed from studies including consecutive patients meeting diagnostic criteria for IBS. Methods4 databases were searched from 1978-2020. Studies were included if they evaluated the prevalence of these conditions in secondary healthcare setting. Estimated pooled rates were calculated and statistical heterogeneity between studies was evaluated using Q and I2 statistics.ResultsSeven studies (n=597) estimated the pooled prevalence for BAD as 41% (95% CI 29-54). 17 studies (n=5,068) estimated that of MC as 3% (95% CI 2-4%). Two studies (n=478) suggested a rate of 4·6% (range: 1·8-6·1%) for PEI. Using breath testing, 26 studies (n=6,700) and 13 studies (n=3,415) estimated the prevalence of lactose and fructose malabsorption as 54% (95% CI 44-64%) and 43% (95% CI 23-62%); 36 studies (n=4,630) and 22 studies (n=2,149) estimated that of SIBO as 49% (95% CI 40-57%) with lactulose and 19% (95% CI 13-27%) with glucose. Rates of all conditions were significantly higher than in healthy controls.ConclusionA significant proportion of patients presenting to secondary care with IBS have an organic condition which may account for their symptoms. Failure to exclude such conditions will deny patients effective treatment.