bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mindfulness augmentation for anxiety through concurrent use of transcranial direct current stimulation: a randomized double-blind study
Authors: Nishida Keiichiro , Morishima Yosuke , Pascual-Marqui Roberto D. , Minami Shota , Yamane Tomonari , Michikura Masahito , Ishikawa Hideki , Kinoshita Toshihiko 
Published: November 2021

AbstractTranscranial direct current stimulation (tDCS) have revealed the capability to augment various types of behavioural interventions. We aimed to augment the effects of mindfulness, suggested for reducing anxiety, with concurrent use of tDCS. We conducted a double-blind randomized study with 58 healthy individuals. We introduced treadmill walking for focused meditation and active or sham tDCS on the left dorsolateral prefrontal cortex for 20 min. We evaluated outcomes using State-Trait Anxiety Inventory-State Anxiety (STAI) before the intervention as well as immediately, 60 min, and 1 week after the intervention, and current density from electroencephalograms (EEG) before and after the intervention. The linear mixed-effect models demonstrated that STAI-state anxiety showed a significant interaction effect between 1 week after the intervention and tDCS groups. As for alpha-band EEG activity, the current density in the rostral anterior cingulate cortex (rACC) was significantly reduced in the active compared with the sham stimulation group, and a significant correlation was seen between changes in STAI-trait anxiety and the current density of the rACC in the active stimulation group. Our study provided that despite this being a one-shot and short intervention, the reduction in anxiety lasts for one week, and EEG could potentially help predict its anxiolytic effect.
Socioeconomic variation of multimorbidity in Colombian older adults
Authors: Ballesteros Silvia Marcela , Moreno-Montoya José , Grooten Wilhelmus Johannes Andreas , Barrera-López Pedro , De la Hoz-Valle José A. 
Published: November 2021

AbstractMultimorbidity (MM) prevalence among older adults is increasing worldwide. Variations regarding the socioeconomic characteristics of the individuals and their context have been described, mostly in high-income settings. However, further research is needed to understand the effect of the coexistence of infectious diseases along with socioeconomic factors regarding MM. This study aims to examine the variation of MM regarding infectious diseases mortality after adjusting for socioeconomic factors. A cross-sectional multilevel study with a nationally representative sample of 17,571 Colombian adults of 60 years of age or older was conducted. Individual socioeconomic, demographic, childhood and health related characteristics, as well as group level variables (multidimensional poverty index and infectious diseases mortality rate) were analyzed. A two-level stepwise structural equation model was used to simultaneously adjust for the individual and contextual effects. Multimorbidity prevalence was 62.3% (95% CI 61.7–62.9). In the multilevel adjusted models, age, female sex, having functional limitations, non-white ethnicity, high body mass index, higher income, physical inactivity and living in urban areas were associated with multimorbidity among the sample for this study. The median odds ratio for multidimensional poverty was 1.18 (1.16–1.19; p = 0.008) and for infectious diseases was 1.25 (1.22–1.28; p = 0.014). This paper demonstrates that MM varies regarding the mortality of infectious diseases and shows a strong association between MM and poverty in a low-middle income country. Differences in the factors involved in the etiology of multimorbidity are expected among wealthy and poor countries regarding availability and prioritization of health services.
Increasing Use of Anticoagulants in Germany and Its Impact on Hospitalization for Tooth Extraction
Authors: von Beckerath Olga , Kröger Knut , Santosa Frans , Nasef Ayat , Kowall Bernd , Stang Andreas 
Published: November 2021

Abstract
Objectives This article aimed to compare nationwide time trends of oral anticoagulant prescriptions with the time trend of hospitalization for tooth extraction (TE) in Germany from 2006 through 2017.
Patients and Methods We derived the annual number of hospital admissions for TE from the Nationwide Hospital Referral File of the Federal Bureau of Statistics and defined daily doses (DDD) of prescribed anticoagulants in outpatients from reports of the drug information system of the statutory health insurance.
Results From 2005 to 2017, annual oral anticoagulation (OAC) treatment rates increased by 143.7%. In 2017, direct oral anticoagulants (DOACs) represented 57.1% of all OAC treatments. The number of cases hospitalized for TE increased by 28.0 only. From all the cases hospitalized for TE in Germany in 2006, 14.2% had a documented history of long-term use of OACs. This proportion increased to 19.6% in 2017. Age-standardized hospitalization rates for all TE cases with long-term use of OACs increased from 6.6 in 2006 to 10.5 cases per 100,000 person-years in 2014 and remained almost unchanged thereafter.
Conclusion Our comparison showed that the large increase in OAC treatment rates in general from 2006 to 2017 had only a small impact on hospitalized TE cases with long-term use of OAC which flattens since 2014.
Ascending of Cycloaddition Strategy for N–O Heterocycles
Authors: Baidya Mahiuddin , Ghosh Prasanjit , Mondal Swati Lekha 
Published: November 2021

AbstractThe N–O heterocycles are biologically relevant scaffolds and versatile building blocks in contemporary organic synthesis. In this short review, we showcase the involvement and elevation of various cycloaddition strategies towards the production of the N–O heterocycles; 1,2-oxazines and 1,2-oxazinanes, 1,2-oxazepanes, and 1,2-oxazetidines. An overview of the advantages and challenges associated with these synthetic endeavors is provided.1	Introduction2	Six-Membered N–O Heterocycles (1,2-Oxazines and 1,2-Oxazinanes)3	Seven-Membered N–O Heterocycles (1,2-Oxazepanes)4	Four-Membered N–O Heterocycles (1,2-Oxazetidines)5	Summary and Outlook
Anastomotic Technique—How to Optimize Success and Minimize Leak Rates
Authors: Man Jeannette , Hrabe Jennifer 
Published: November 2021

AbstractDetermining when to perform a bowel anastomosis and whether to divert can be difficult, as an anastomosis made in a high-risk patient or setting has potential for disastrous consequences. While the surgeon has limited control over patient-specific characteristics, the surgeon can control the technique used for creating anastomoses. Protecting and ensuring a vigorous blood supply is fundamental, as is mobilizing bowel completely, and employing adjunctive techniques to attain reach without tension. There are numerous ways to create anastomoses, with variations on the segment and configuration of bowel used, as well as the materials used and surgical approach. Despite numerous studies on the optimal techniques for anastomoses, no one method has prevailed. Without clear evidence on the best anastomotic technique, surgeons should focus on adhering to good technique and being comfortable with several configurations for a variety of conditions.
New Technologies to Prevent Anastomotic Leak
Authors: Uppal Abhineet , Pigazzi Alessio 
Published: November 2021

AbstractLeaks from anastomoses can be a serious complication of any gastrointestinal resection. Leaks lead to increased morbidity, delayed postoperative recovery, and potential delays in adjuvant treatment in cancer cases. Prevention of anastomotic leak has been an area of ongoing research for decades. Methods of assessing bowel perfusion have been developed that may provide forewarning of anastomotic compromise. Physical reinforcement of the anastomosis with buttressing material is an available method employed with the goal of preventing leaks. Liquid-based sealants have also been explored. Lastly, interactions between the gut microbiome and anastomotic healing have been investigated as a mean of manipulating the microenvironment to reduce leak rates. Though no single technology has been successful in eliminating leaks, an understanding of these developing fields will be important for all surgeons who operate on the gastrointestinal tract.
Inefficiencies in Residency Matching Associated with Gale–Shapley Algorithms
Authors: Van Gelder Russell N. , Wu Yue , Taravati Parisa , Yanagihara Ryan T. , Francis Courtney E. , Blazes Marian , Lee Cecilia S. , Lee Aaron Y. 
Published: November 2021

Abstract
Objective This study aimed to investigate emerging trends and increasing costs in the National Residency Matching Program (NRMP) and San Francisco Residency and Fellowship Match Services (SF Match) associated with the current applicant/program Gale–Shapley-type matching algorithms.
Design A longitudinal observational study of behavioral trends in national residency matching systems with modeling of match results with alternative parameters.
Patients and Methods We analyzed publicly available data from the SF Match and NRMP websites from 1985 to 2020 for trends in the total number of applicants and available positions, as well the average number of applications and interviews per applicant for multiple specialties. To understand these trends and the algorithms' effect on the residency programs and applicants, we analyzed anonymized rank list and match data for ophthalmology from the SF Match between 2011 and 2019. Match results using current match parameters, as well as under conditions in which applicant and/or program rank lists were truncated with finalized rank lists, were analyzed.
Results Both the number of applications and length of programs' rank lists have increased steadily throughout residency programs, particularly those with competitive specialties. Capping student rank lists at seven programs, or less than 80% of the average 8.9 programs currently ranked, results in a 0.71% decrease in the total number of positions filled. Similarly, capping program rank lists at seven applicants per spot, or less than 60% of the average 11.5 applicants ranked per spot, results in a 5% decrease in the total number of positions filled.
Conclusion While the number of ophthalmology positions in the United States has increased only modestly, the number of applications under consideration has increased substantially over the past two decades. The current study suggests that both programs and applicants rank more choices than are required for a nearly complete and stable match, creating excess cost and work for both applicants and programs. “Stable-marriage” type algorithms induce applicants and programs to rank as many counterparties as possible to maximize individual chances of optimizing the match.
Inaccuracy of Standard 2D Photography for the Diagnosis of Cephalic Malposition of Lateral Crural Cartilages
Authors: Bastaninejad Shahin , Tajdini Ardavan , Rezaie Yasaman 
Published: November 2021

AbstractLateral crural cephalic malposition (LCCM) is a well-known deformity of the nasal tip which contributes to functional disturbances of the external nasal valve. Accurate diagnosis of this deformity helps surgeons plan for better outcomes. A total of 176 candidate patients for primary rhinoplasty underwent standard 2D medical photography of the face. Senior authors analyzed photography results and differentiated the patients with LCCM. In addition, we measured the angle between the dorsal septum and lateral end of the long axis of the alar cartilage in the operation room. Ninety-five patients were diagnosed with LCCM on photography. As much as 31.3% (55) of all the patients had LCCM in intraoperative measurements. The sensitivity and specificity of 2D photography for diagnosing LCCM were 0.7924 and 0.5391, respectively. The main surgical techniques for correction of LCCM were alar repositioning (34.3% in total, 56% in LCCM patients) and lateral crural strut graft (43.8% in total, 69% in LCCM patients). LCCM is overdiagnosed via 2D photography, and this method lacks sensitivity. The overall frequency of LCCM seems to be lower than the previously reported frequency. For optimal results in rhinoplasty, surgeons must focus on the best contouring and function rather than solely correcting angles and rotations.
Hemiepiphysiodesis for the Correction of Distal Femoral Valgus in Growing Dogs
Authors: Vezzoni Luca , Forzisi Ida , Ferretti Antonio , Vezzoni Aldo 
Published: November 2021

Abstract
Objectives The aim of this study was to describe hemiepiphysiodesis for the treatment of distal femoral valgus in immature dogs and to evaluate its effect on the anatomical lateral distal femoral angle (aLDFA).
Methods Skeletally immature dogs with distal femoral valgus deformities that had undergone hemiepiphysiodesis between November 2012 and March 2020 at two private veterinary practices were included. Criteria for inclusion in the study were a preoperative aLDFA below the previously published reference range (94 ± 3.3 degrees) and radiographs of the femur taken preoperatively and at growth plate closure.
Results A total of 11 dogs fulfilled the inclusion criteria, and a total of 17 limbs were treated. The mean aLDFA was 82.1 ± 3.2 degrees (range: 76–87 degrees) preoperatively and 93.1 ± 5 degrees (range: 76–99 degrees) at the final re-evaluation. The mean difference between the preoperative and final aLDFA was +11 degrees, which was significant. Undercorrection occurred in 2/17 cases, whereas overcorrection was not recorded. The implants were removed in 12/17 cases, and rebound growth occurred in 3 of these.
Clinical Significance Hemiepiphysiodesis for the treatment of distal femoral valgus is a technique that allows for increase in aLDFA and should be considered as an early treatment in affected immature dogs. Monitoring for possible overcorrection using serial radiography is important. Implant removal when the desired aLDFA has been achieved is recommended because the incidence of rebound growth is uncommon in dogs.
Lymphoepithelioma-Like Carcinoma of Urinary Bladder with Diagnostic Dilemma: Case Report of a Rare Variant of Urothelial Carcinoma
Authors: Saini Swati , Garg Monika , Goyal Shaina , Chaudhary Anita 
Published: November 2021

AbstractLymphoepithelioma-like carcinoma of the urinary bladder is a rare variant of urothelial carcinoma that was first described by Zukerberg in 1991 and confirmed as a type of urothelial carcinoma by the WHO classification of the urinary system tumors. A 63-year-old man presented with the chief complaint of gross hematuria for 2 months. Sections from transurethral resection of the bladder revealed urothelial carcinoma. A radical cystoprostatectomy was performed and a final histopathological examination revealed high-grade muscle-invasive urothelial carcinoma, lymphoepithelial variant. The patient has been receiving adjuvant chemotherapy with no recurrence reported to date. This is the third case reported in India to date to the best of our knowledge. Owing to its rare presentation, no definite treatment guidelines have been established for this entity. Various studies from the English literature suggest a conservative approach.
On the number of equilibria balancing Newtonian point masses with a central force
Authors: Arustamyan Nickolas , Cox Christopher , Lundberg Erik , Perry Sean , Rosen Zvi 
Published: November 2021

We consider the critical points (equilibria) of a planar potential generated by n Newtonian point masses augmented with a quadratic term (such as arises from a centrifugal effect). Particular cases of this problem have been considered previously in studies of the circular-restricted n-body problem. We show that the number of equilibria is finite for a generic set of parameters, and we establish estimates for the number of equilibria. We prove that the number of equilibria is bounded below by n + 1, and we provide examples to show that this lower bound is sharp. We prove an upper bound on the number of equilibria that grows exponentially in n. In order to establish a lower bound on the maximum number of equilibria, we analyze a class of examples, referred to as “ring configurations,” consisting of n − 1 equal masses positioned at vertices of a regular polygon with an additional mass located at the center. Previous numerical observations indicate that these configurations can produce as many as 5n − 5 equilibria. We verify analytically that the ring configuration has at least 5n − 5 equilibria when the central mass is sufficiently small. We conjecture that the maximum number of equilibria grows linearly with the number of point masses. We also discuss some mathematical similarities to other equilibrium problems in mathematical physics, namely, Maxwell’s problem from electrostatics and the image counting problem from gravitational lensing.
Molecular point groups and symmetry in external magnetic fields
Authors: Pausch Ansgar , Gebele Melanie , Klopper Wim 
Published: November 2021

As quantum-chemical calculations of molecules in static external magnetic fields are becoming increasingly popular, the description of molecular symmetry under such conditions is also becoming more and more relevant. Using group theory, a general scheme of identifying the molecular point group in an external magnetic field is constructed. For both point groups that are non-existent in the absence of a field (C∞ and C∞h) and their double groups, the character tables are presented. General properties of all possible point groups are discussed, and it is mathematically proven that they are all Abelian.
Hexavalent sperm-binding IgG antibody released from vaginal film for development of potent on-demand nonhormonal female contraception
Authors: Shrestha Bhawana , Vincent Kathleen , Schaefer Alison , Zhu Yong , Vargas Gracie , Motamedi Massoud , Swope Kelsi , Morton Josh , Simpson Carrie , Pham Henry , Brennan Miles B. , Pauly Michael H. , Zeitlin Larry , Bratcher Barry , Whaley Kevin J. , Moench Thomas R. , Lai Samuel K. 
Published: November 2021

Significance
Nearly half of all pregnancies in the United States are unintended due to millions of women avoiding available hormonal contraceptive methods as a result of real and/or perceived side effects associated with the use of exogenous hormones. Topical vaginal delivery of antisperm monoclonal antibodies that could agglutinate sperm into clusters too large to penetrate mucus and prevent sperm from reaching the egg represents a potentially safe and potent mechanism for nonhormonal contraception. We report here the engineering of a vaginal film loaded with hexavalent (i.e., 6 Fab) antisperm IgG, made using GMP manufacturing processes, that possesses significantly superior agglutination potency than the parent IgG, enabling potent on-demand nonhormonal contraception via effectively agglutinating all human sperm within minutes.
Amyloid β 42 fibril structure based on small-angle scattering
Authors: Lattanzi Veronica , André Ingemar , Gasser Urs , Dubackic Marija , Olsson Ulf , Linse Sara 
Published: November 2021

Significance
Alzheimeŕs disease is one of the major global health challenges. Neuronal cell dysfunction and death are connected to the self-assembly of the amyloid β peptide (Aβ42) into oligomeric and fibrillar aggregates. The fibril surface can catalyze the formation of toxic oligomers via secondary nucleation. Access to a high-resolution structure of Aβ42 fibrils would provide a valuable basis for design of inhibitors of oligomer generation and toxicity in the form of fibril-binders and thus significantly contribute to the development of therapeutics against Alzheimer’s disease. A combination of methods may be most fruitful toward this aim. We show that small-angle X-ray scattering data, in combination with a solid-state NMR structure of the filament core, can reveal a detailed fibril model.
Insecure Institutions
Authors: Helmke Gretchen , Jeong Yeonkyung , Kim Jae-Eun C. 
Published: November 2021

AbstractMost theories of judicial politics are built around explaining the puzzle of judicial independence. This article instead theorizes explicitly about the conditions under which politicians are prone to manipulate their courts. By positing that courts can partly endogenously shape leaders’ fate at the hands of legislative opponents, we argue that greater political insecurity leads presidents to gut judicial independence, not shore it up. Drawing on a novel data set of judicial crises across 18 Latin American countries following the third wave of democratization, we show that variation in judicial crises is systematically correlated with the president’s risk of nonelectoral instability as captured by the history of past presidential crises, presidential power, and antigovernmental protests. To identify whether the effects of protest on judicial manipulation are causal, we use an instrumental variable approach based on international commodity prices weighted for each country.
Lower Courts in Interbranch Conflict
Authors: Strayhorn Joshua A. 
Published: November 2021

AbstractDo inferior courts play a meaningful role in interbranch disputes between the judicial and other branches? In interbranch conflicts involving the judiciary, lower courts move first and may shape the direction of conflict before high courts intervene directly. This paper explores how this organizational feature affects the judiciary’s ability and willingness to constrain other branches, developing a formal model of an interbranch dispute involving a hierarchical judicial branch. The model demonstrates multiple mechanisms through which lower court decisions may alter the outcomes of interbranch disputes and explores when lower courts will initiate conflict with the other branches.
Aesthetic Preferences and Policy Preferences as Determinants of US Supreme Court Writing Style
Authors: Budziak Jeffrey , Lempert Daniel 
Published: November 2021

AbstractRecent literature on writing style in US Supreme Court opinions has focused on style as a means of furthering justices’ policy goals. In particular, an opinion’s clarity is proposed to make the implementation of the announced policy more likely. We give a formal argument that the observed distribution of opinion clarity is not easily reconcilable with justices who are striving to write clearly in service of policy implementation-related goals; this is true even if there are case-level costs that sometimes make writing clearly more difficult. We propose that justices having aesthetic preferences – essentially, stylistic preferences over opinion language that are unrelated to policy implementation – that they weight heavily could explain the observed distribution of opinion clarity. Our analysis of some 4,500 majority opinions 1955–2008 is largely consistent with our theoretical argument.
Search for variability in Newton’s constant using local gravitational acceleration measurements
Authors: Bhagvati Srinikitha , Desai Shantanu 
Published: November 2021

Abstract
In a recent work, Dai (2021 Phys. Rev. D 103 064059) searched for a variability in Newton’s constant G using the International Geodynamics and Earth Tide Service based gravitational acceleration measurements. However, this analysis, obtained from χ
2 minimization, did not incorporate the errors in the gravitational acceleration measurements. We carry out a similar search with one major improvement, wherein we incorporate these aforementioned errors. To model any possible variation in the gravitational acceleration, we fit the data to four models: a constant value, two sinusoidal models, and finally, a linear model for the variation of gravitational acceleration. We find that none of the four models provides a good fit to the data, showing that there is no evidence for a periodicity or a linear temporal variation in the acceleration measurements. We then redid these analyses after accounting for an unknown intrinsic scatter. After this, we find that although a constant model is still favored over the sinusoidal models, the linear variation for G is marginally preferred over a constant value, using information theory-based methods.