bluuebunny/crossref_metadata_2025_split huggingface dataset:
How far are the benefits of the Islamic Philanthropy and Social Entrepreneurship movement?
Authors: Dwi Saputra Arief , Rahmatia Alfina , Muslimah Muslimah 
Published: December 2021

Islamic philanthropy and social entrepreneurship have created solutions in addressing the problems that occur for maximizing economic, social, and religious activity. In this study review, Islamic philanthropy links the elements of zakat, infaq, sadaqah, and waqf in terms of social entrepreneurship with elements of social value, civil society, innovation, and economic activity. The data was obtained using literature studies and interviews on Lazismu Bengkulu as an Islamic philanthropic movement and CV. Presidium on the social entrepreneurship movement. Then, data were processed using Nvivo and drawn conclusions through word similarity analysis. Findings. The synergy between employers and society plays a role in addressing problems against poverty alleviation, wealth equality, community welfare, creating social benefits, optimizing social capital, innovation in problem-solving efforts, building a balance between social activities and business activities. Integration of these two movements explains the dominant increase compared to the decline by presenting an impact on production, consumption, investment, economic growth, and economic stability. In the analysis of word similarity, efforts of synergy and integration concluded that both movements could be implemented in practice because they support each other and have close links to achieve goals and increase the dominant impact of social, economic, and religious activities.
Electrocardiographic Features of Left Ventricular Diastolic Dysfunction and Heart Failure With Preserved Ejection Fraction: A Systematic Review
Authors: Van Ommen Anne-Mar , Kessler Elise Laura , Valstar Gideon , Onland-Moret N. Charlotte , Cramer Maarten Jan , Rutten Frans , Coronel Ruben , Den Ruijter Hester 
Published: December 2021

Background: Electrocardiographic features are well-known for heart failure with reduced ejection fraction (HFrEF), but not for left ventricular diastolic dysfunction (LVDD) and heart failure with preserved ejection fraction (HFpEF). As ECG features could help to identify high-risk individuals in primary care, we systematically reviewed the literature for ECG features diagnosing women and men suspected of LVDD and HFpEF.Methods and Results: Among the 7,127 records identified, only 10 studies reported diagnostic measures, of which 9 studied LVDD. For LVDD, the most promising features were T-end-P/(PQ*age), which is the electrocardiographic equivalent of the passive-to-active filling (AUC: 0.91–0.96), and repolarization times (QTc interval ≥ 350 ms, AUC: 0.85). For HFpEF, the Cornell product ≥ 1,800 mm*ms showed poor sensitivity of 40% (AUC: 0.62). No studies presented results stratified by sex.Conclusion: Electrocardiographic features are not widely evaluated in diagnostic studies for LVDD and HFpEF. Only for LVDD, two ECG features related to the diastolic interval, and repolarization measures showed diagnostic potential. To improve diagnosis and care for women and men suspected of heart failure, reporting of sex-specific data on ECG features is encouraged.
Using Machine Learning Approaches to Predict Target Gene Expression in Rice T-DNA Insertional Mutants
Authors: Chien Ching-Hsuan , Huang Lan-Ying , Lo Shuen-Fang , Chen Liang-Jwu , Liao Chi-Chou , Chen Jia-Jyun , Chu Yen-Wei 
Published: December 2021

To change the expression of the flanking genes by inserting T-DNA into the genome is commonly used in rice functional gene research. However, whether the expression of a gene of interest is enhanced must be validated experimentally. Consequently, to improve the efficiency of screening activated genes, we established a model to predict gene expression in T-DNA mutants through machine learning methods. We gathered experimental datasets consisting of gene expression data in T-DNA mutants and captured the PROMOTER and MIDDLE sequences for encoding. In first-layer models, support vector machine (SVM) models were constructed with nine features consisting of information about biological function and local and global sequences. Feature encoding based on the PROMOTER sequence was weighted by logistic regression. The second-layer models integrated 16 first-layer models with minimum redundancy maximum relevance (mRMR) feature selection and the LADTree algorithm, which were selected from nine feature selection methods and 65 classified methods, respectively. The accuracy of the final two-layer machine learning model, referred to as TIMgo, was 99.3% based on fivefold cross-validation, and 85.6% based on independent testing. We discovered that the information within the local sequence had a greater contribution than the global sequence with respect to classification. TIMgo had a good predictive ability for target genes within 20 kb from the 35S enhancer. Based on the analysis of significant sequences, the G-box regulatory sequence may also play an important role in the activation mechanism of the 35S enhancer.
Study on the Soft Magnetic Properties of FeSiB/EP Composites by Direct Ink Writing
Authors: Qing Ma , Chong Teng , Jing Hu , Sun Baoan 
Published: December 2021

Fe-based amorphous alloy has excellent soft magnetic properties; traditionally, Fe-based amorphous alloy such as soft magnetic devices was fabricated by insulation enveloping and suppression molding methods. In this process, the aging of organic envelope materials and the crystallization of Fe-based amorphous alloy were usually occurring, accompanying with low magnetic induction and poor mechanical properties. The direct ink writing (DIW) technique can make complex-shaped parts and needs no heating treatment after forming, which can avoid the effect of traditional molding process. In the present study, varying mass fraction FeSiB/EP composite parts were prepared by the DIW technique with the Fe-based amorphous alloy powder and epoxy resin, in which microscopic morphology, magnetic properties, and mechanical properties of FeSiB/EP soft magnetic composites were studied. The results indicate that the slurry with iron powder mass fraction of 92.3, 92.6, and 92.8 wt% has good printing performance and self-support ability, which is suitable for DIW. The density of the printed parts is about 4.317, 4.449, and 4.537 g/cm3, which is almost similar with the iron powder. The tensile strength and elongation of printing parts are significantly improved compared with the pure epoxy resin. From the photos of microscopic morphology of printing parts, it can be seen that FeSiB powders are evenly dispersed in EP, no pores, and defects, with the proportion increasing of powders; the insulation coating thickness decreases; and the magnetic performance improves. The optimal sample is 92.8 wt% FeSiB/EP, in which saturation magnetic induction strength is 137.9759 emu/g and coercivity is 4.6523 A/m.
Influence of Combined Mechanical Processes on Tribological Properties of Tool Steels Vanadis 8 and Vancron 40 With a Similar Hardness
Authors: Toboła Daniel , Łętocha Aneta 
Published: December 2021

Surface integrity is important factor for components exposed to wear, like cold working tools, which need to possess high hardness combined with high wear resistance. Surface treatments such as grinding, hard turning, and hard turning with slide burnishing have been developed for its improvement. Vancron 40 and Vanadis 8 tool steels, of different chemical composition and different types and amounts of carbides, were now investigated. Heat treatment was carried out in vacuum furnaces with gas quenching to hardness of Vancron 64 ± 1 HRC and of Vanadis 65 ± 1 HRC. 3D topography, optical and scanning electron microscopy, X-ray diffraction and ball-on-disc tribological tests against Al2O3 and 100Cr6 balls as counterparts were used to examine wear and friction. For both steels, the lowest values of dynamic frictions and wear rates against Al2O3 counterbodies were achieved after sequential process of hard turning with slide burnishing with a burnishing force of 180 N. For alumina balls, the increase of wear resistance, achieved after hard turning plus burnishing in comparison to grinding exceeds 50 and 60%, respectively for Vanadis 8 and Vancron 40 steels.
Segmentation Errors in the Measurement of Volumetric Parameters by Swept-Source Anterior Segment Optical Coherence Tomography
Authors: Chen Hailiu , Meng Jie , Lu Peng , Ye Dan , Li Yunxuan , Cheng Lu , Li Yangyunhui , Liang Xiaoling , Huang Wenyong , Huang Jingjing 
Published: December 2021

Purpose: To investigate the error rate of segmentation in the automatic measurement of anterior chamber volume (ACV) and iris volume (IV) by swept-source anterior segment optical coherence tomography (SS-ASOCT) in narrow-angle and wide-angle eyes.Methods: In this study, fifty eyes from 25 narrow-angle subjects and fifty eyes from 25 wide-angle subjects were enrolled. SS-ASOCT examinations were performed and each SS-ASOCT scan was reviewed, and segmentation errors in the automatic measurement of ACV and IV were classified and manually corrected. Error rates were compared between the narrow-angle and the wide-angle groups, and ACV and IV before and after manual correction were compared.Results: A total of 12,800 SS-ASOCT scans were reviewed. Segmentation error rates of angle recess, iris root, posterior surface of the iris, pupil margin, and anterior surface of the lens were 84.06, 93.30, 13.15, 59.21, and 25.27%, respectively. Segmentation errors of angle recess, iris root, posterior surface of the iris, and pupil margin occurred more frequently in narrow-angle eyes, while more segmentation errors of the anterior surface of the lens were found in wide-angle eyes (all P &lt; 0.001). ACV decreased and IV increased significantly after manual correction of segmentation errors in both groups (all P &lt; 0.01).Conclusion: Segmentation errors were prevalent in the volumetric measurement by SS-ASOCT, particularly in narrow-angle eyes, leading to mismeasurement of ACV and IV.
Long-Term Outcomes of IgG4-Related Ophthalmic Disease in a Chinese IgG4-Related Disease Cohort
Authors: Gan Linyang , Luo Xuan , Fei Yunyun , Peng Linyi , Zhou Jiaxin , Li Jieqiong , Lu Hui , Liu Zheng , Zhang Panpan , Liu Xiaowei , Zhang Wen 
Published: December 2021

Purpose: To define the treatment response and long-term outcomes of a large IgG4-related ophthalmic disease (IgG4-ROD) cohort.Methods: A total of 132 patients with a minimum follow-up of 1 year were included in this study. Demographic, clinical, and laboratory data were collected. Treatment response was assessed by the IgG4-RD responder index (IgG4-RD RI). Risk factors for relapse were analyzed with the multivariate Cox regression analysis.Results: The median follow-up time was 39 months. Lacrimal gland involvement was detected in 87.9% of cases. Extraocular muscles, the trigeminal nerve, and other soft tissue were affected in 25.8, 6.1, and 18.2% of patients. The relapse rate of watchful waiting, glucocorticoid monotherapy, immunosuppressant monotherapy, and combination therapy was 50.0, 51.7, 50.0, and 26.7% (p = 0.038), respectively. The combination therapy group exhibited shorter glucocorticoids therapy duration (36 vs. 48 months, p = 0.009) and maintenance period (24 vs. 42 months, p = 0.003). At the 6th month, the median IgG4-RD RI declined from 12 to 1 and 105 (79.5%) patients achieved complete response (CR). Relapse occurred in 49 (37.1%) patients. The multivariate Cox regression analysis exhibited that CR at the 6th month was an independent protective factor for relapse. Patients with multiple ocular lesions suffered from a higher risk of relapse. No patient had severe adverse reactions to the treatment in this study.Conclusion: Relapse was common in patients with IgG4-ROD. Patients receiving combination therapy showed a lower relapse rate and a shorter glucocorticoids therapy period. The presence of multiple ocular lesions was associated with a higher risk of relapse. CR at the 6th month might be a predictor for a better prognosis in IgG4-ROD. Thus, a more aggressive regimen should be prescribed for patients with a poor initial response.
Machine Retrograde Perfusion of Deceased Donor Kidneys: A Prospective Study
Authors: Zeng Jun , Jia ZiHao , Lin Tao , Song TuRun 
Published: December 2021

Objective: To maximize the utilization of potential kidneys, improving perfusion and preservation techniques is necessary.Methods: We investigated the safety and efficacy of retrograde machine perfusion of kidneys from deceased donors. A total of 30 kidneys were included and all the grafts were preserved in the Kidney Transporter machines. A total of 15 kidneys that received retrograde perfusion (RP) were selected as the RP group (n = 15) and their counterparts received standard antegrade perfusion (AP) as the control group (n = 15).Results: All the recipients were followed up for 6 months. Renal resistance in the RP group remained stable during the perfusion. There was no primary nonfunction. No difference in the incidence of delayed graft function was found in both groups (3 in RP vs. 2 in AP, p = 0.62). The RP group had lower serum creatinine (RP vs. AP, 102.20 vs. 138.67, p = 0.05) and blood urea nitrogen (RP vs. AP, 6.44 vs. 8.71, p = 0.05) than that in the AP group at 6 months. Both the groups had comparable estimated glomerular filtration rate and cystatin C within 6 months.Conclusion: This novel technique may be an effective and safe alternative for kidney preservation.
Comparing the MSIS-29 and the Health Utilities Index Mark III in Multiple Sclerosis
Authors: Marrie Ruth Ann , Dolovich Casandra , Cutter Gary R. , Fox Robert J. , Salter Amber 
Published: December 2021

Objective: Since the properties of health-related quality of life measures vary across samples, studies directly comparing the properties of different measures can be useful in understanding their relative strengths and limitations. We aimed to compare the psychometric properties of the Health Utilities Index Mark III (HUI3) and the Multiple Sclerosis Impact Scale-29 (MSIS-29).Methods: In Spring 2020, North American Research Committee on Multiple Sclerosis (NARCOMS) Registry participants completed the HUI3, MSIS-29, Patient Determined Disease Steps (PDDS) and SymptoMScreen. For the HUI3 and MSIS-29 we assessed floor and ceiling effects, construct validity, and internal consistency reliability. We used relative efficiency to compare the discriminating ability of the two measures with respect to disability.Results: We included 5,664 participants in the analysis, with mean (SD) age 63 (10.1) years; 4,579 (80.8%) were women. For the HUI3 the mean (SD) score was 0.44 (0.32), for the MSIS-29 physical it was 34.0 (24.2) and for the MSIS-29 psychological it was 25.9 (20.4). Neither of the measures had floor or ceiling effects, and internal consistency reliability was &gt; 0.70 for both. The HUI3 and MSIS-29 physical were strongly correlated (r = −0.78; 95%CI:−0.79,−0.77). The correlation between the HUI3 and MSIS-29 psychological was weaker but remained moderately strong (r = −0.64; 95%CI:−0.66,−0.63). After adjusting for sociodemographic and clinical factors, relative efficiency to discriminate between disability (PDDS) groups was highest for the MSIS-29 physical scale, followed by the HUI3.Conclusion: Both measures had adequate validity and reliability. The MSIS-29 physical discriminated between disability groups better than the HUI3.
Optimal Transport Scenario With Rotary Air Transport for Access to Endovascular Therapy Considering Patient Outcomes and Cost: A Modeling Study
Authors: Wheaton Ashlee , Fok Patrick T. , Holodinsky Jessalyn K. , Vanberkel Peter , Volders David , Kamal Noreen 
Published: December 2021

Background and Purpose: For an ischemic stroke patient whose onset occurs outside of the catchment area of a hospital that is capable of Endovascular Treatment (EVT) and whose stroke is suspected to be caused by a large vessel occlusion (LVO), a transportation dilemma exists. Bypassing the nearest stroke hospital will delay Alteplase but expedite EVT. Not bypassing allows for confirmation of an LVO diagnosis before transfer to an EVT-enabled facility, but ultimately delays EVT. Air transport can reduce a patient's overall time to treatment however, it is costly. We expanded on an existing model to predict where Drip-and-Ship vs. Mothership provides better outcomes by including rotary air transport, and we also included prediction of where either the transport method was most cost effective.Methods: An existing model predicts the outcome of patients who screen positive for an LVO in the field based on how they were transported, Drip-and-Ship (alteplase-only facility first, then EVT-enabled facility) or Mothership (direct to EVT-enabled facility). In our model, the addition of rotary wing transportation was conditionally applied to inter-facility transfer scenarios where it provided a time advantage. Both patient outcome and transport cost functions were developed for Mothership and Drip-and-Ship strategies including transfers via either ground or air depending on the conditional probabilities. Experiments to model real world scenarios are presented by varying the driving time between the alteplase-only and EVT-enabled facility, time to treatment efficiencies at the alteplase-only facility, and EVT eligibility for LVO patients. Patient outcome and transport costs were evaluated for Mothership and Drip-and-Ship strategies.Results: The results are presented in temporospatial diagrams that are color coded to indicate which strategy optimizes the objectives. In most regions, there was overall agreement between the optimal solution when considering patient outcomes or transport costs. Small regions exist where outcome and cost are divergent; however, the difference between the divergence in Mothership and Drip-and-Ship in these regions is marginal.Conclusions: The optimal transport method can be optimized for both patient outcomes and transport costs.
Impact of Common Dizziness Associated Symptoms on Dizziness Handicap in Older Adults
Authors: Prell Tino , Wassermann Alexander , Zipprich Hannah M. , Finn Sigrid , Axer Hubertus 
Published: December 2021

Background: A cross-sectional observational study was designed to determine the impact of dizziness associated symptoms on the dizziness handicap inventory (DHI) in older adults (≥60 years).Methods: In total, 785 individuals referred to a multidisciplinary dizziness unit were assessed. Participants completed self-report questionnaires with general questions about symptoms of dizziness as well as the DHI. The DHI subscores (physical, functional, emotional) were calculated. Medical diagnoses were collected from the medical records of the patients. One-way MANOVA and networking analysis were used to analyze the impact of dizziness associated symptoms on dizziness handicap.Results: Most patients reported swaying dizziness (60.6%) and feeling of unsteadiness (59.8%) with substantial overlap between the types of dizziness. Most frequent dizziness associated symptoms were ear noise/tinnitus, visual problems, and nausea/vomiting. Network analysis revealed that visual disturbances, headache, and hearing impairment were associated with higher DHI and explained 12% of the DHI variance in the linear regression. In the one-way MANOVA visual problems and headache had an effect on all three DHI subscores, while hearing impairment was associated with the functional and emotional subscores of DHI.Conclusion: Distinct dizziness associated symptoms have substantial impact on dizziness handicap in older adults. A multifactorial assessment including these symptoms may assist in tailoring therapies to alleviate dizziness handicap in this group.
Gait Adaptation to a Phase-Specific Nociceptive Electrical Stimulation Applied at the Ankle: A Model to Study Musculoskeletal-Like Pain
Authors: Bertrand-Charette Michaël , Jeffrey-Gauthier Renaud , Roy Jean-Sébastien , Bouyer Laurent J. 
Published: December 2021

Introduction: Lower limb pain, whether induced experimentally or as a result of a musculoskeletal injury, can impair motor control, leading to gait adaptations such as increased muscle stiffness or modified load distribution around joints. These adaptations may initially reduce pain but can also lead to longer-term maladaptive plasticity and to the development of chronic pain. In humans, many current experimental musculoskeletal-like pain models are invasive, and most don’t accurately reproduce the movement-related characteristics of musculoskeletal pain. The main objective of this study was to measure pain adaptation strategies during gait of a musculoskeletal-like experimental pain protocol induced by phase-specific, non-invasive electrical stimulation.Methods: Sixteen healthy participants walked on a treadmill at 4 km/h for three consecutive periods (BASELINE, PAIN, and POST-PAIN). Painful electrical stimulations were delivered at heel strike for the duration of heel contact (HC) using electrodes placed around the right lateral malleolus to mimic ankle sprains. Gait adaptations were quantified bilaterally using instrumented pressure-sensitive insoles. One-way ANOVAs and group time course analyses were performed to characterize the impact of electrical stimulation on heel and forefoot contact pressure and contact duration.Results: During the first few painful strides, peak HC pressure decreased on the painful side (8.6 ± 1.0%, p &lt; 0.0001) and increased on the non-stimulated side (11.9 ± 0.9%, p &lt; 0.0001) while HC duration was significantly reduced bilaterally (painful: 12.1 ± 0.9%, p &lt; 0.0001; non-stimulated: 4.8 ± 0.8%, p &lt; 0.0001). No clinically meaningful modifications were observed for the forefoot. One minute after the onset of painful stimulation, perceived pain levels stabilized and peak HC pressure remained significantly decreased on the painful side, while the other gait adaptations returned to pre-stimulation values.Discussion: These results demonstrate that a non-invasive, phase-specific pain can produce a stable painful gait pattern. Therefore, this protocol will be useful to study musculoskeletal pain locomotor adaptation strategies under controlled conditions.