bluuebunny/crossref_metadata_2025_split huggingface dataset:
A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration
Authors: Tautou Marie , Eddarkaoui Sabiha , Descamps Florian , Larchanché Paul-Emmanuel , El Bakali Jamal , Goveas Liesel Mary , Dumoulin Mélanie , Lamarre Chloé , Blum David , Buée Luc , Melnyk Patricia , Sergeant Nicolas 
Published: June 2021

Identifying which among several in cellulo pharmacological activities is necessary for the proper in vivo activity is essential for further drug development against Alzheimer’s disease pathophysiological processes. An in-depth structure–activity relationship–based study has been carried out, and two molecules, named MAGS02-14 and PEL24-199, that share a ß-secretase modulatory effect associated or not to a lysosomotropic activity in cellulo have been identified. In terms of chemical formulas, MAGS02-14 and PEL24-199 only differ from each other by a single nitrogen atom. The study aimed to elucidate the in vivo pharmacological effects of lysosomotropic and/or the ß-secretase modulatory activity in a tau pathology mouse model. To address this question, the THY-Tau22 transgenic model of tauopathy was treated with both compounds for 6 weeks in a curative paradigm. Short-term memory, tau burden, and inflammatory processes were analyzed using orthogonal methods, and PEL24-199, but not MAGS02-14, was shown to restore the short-term memory and reduce the neurofibrillary degenerating process. These effects were associated with a reduced phosphorylation of tau, an increased phosphatase expression, and decreased astrogliosis. Our results, therefore, suggest that the lysosomotropic activity may be nonessential for the effect on tau pathology.
Impact of Cost-Related Medication Nonadherence on Economic Burdens, Productivity Loss, and Functional Abilities: Management of Cancer Survivors in Medicare
Authors: Lu Z. Kevin , Xiong Xiaomo , Brown Jacob , Horras Ashley , Yuan Jing , Li Minghui 
Published: June 2021

Background: Cancer survivors are vulnerable to have medication nonadherence. We aimed to estimate the impact of cost-related medication nonadherence on economic burdens, productivity loss, and functional abilities among cancer survivors.Methods: A cross-sectional study was conducted using data from the National Health Interview Survey (NHIS), 2011–2018. Cost-related medication nonadherence was identified based on NHIS prompts. An ordinal logistic regression model was used to determine the impact of cost-related medication nonadherence on survivors’ economic burden. Two negative binomial regression models were implemented to estimate the impact on productivity loss. In addition, four logistic regression models were used to determine the impact on functional abilities. The weighted analysis was used to generate national estimates.Results: Among 35, 773, 286 cancer survivors, 15, 002, 192 (41.9%) respondents reported that they experienced cost-related medication nonadherence. Compared to cancer survivors without cost-related medication nonadherence, those with nonadherence were significantly associated with an increased economic burden (OR: 1.89, 95% CI: 1.70–2.11). Also, cancer survivors with cost-related medication nonadherence were significantly more likely to have an increased bed disability day (IRR: 1.46, 95% CI: 1.21–1.76). In terms of the limitations, cancer survivors with nonadherence were significantly more likely to have both activity limitation (OR: 1.42, 95% CI: 1.25–1.60) and functional limitation (OR: 2.12, 95% CI: 1.81–2.49).Conclusion: Cost-related medication nonadherence increased economic burdens, productivity loss, and limitations in functional abilities among cancer survivors. Strategies are needed to help cancer survivors with cost-related medication nonadherence to be adherent to prescriptions.
Does Cancer Type Influence the Impact of Recurrence? A Review of the Experience of Patients With Breast or Prostate Cancer Recurrence
Authors: Stewart Ross James , Humphris Gerald Michael , Donaldson Jayne , Cruickshank Susanne 
Published: June 2021

Objective: Patients will experience a plethora of issues when faced with a recurrence of their cancer. It is unclear if cancer type is a significant factor in how recurrence is experienced by an individual. The aim of the current review is to explore the evidence base and summarise the experiences of patients specifically with a recurrence of breast or prostate cancer (the most common for women and men, respectively) and then provide a comparison of these experiences. These experiences include the physical, psychological and psychosocial issues that arise at this time.Methods: A systematic search was conducted of studies published between January 1994 and April 2019. Due to the mix of research designs used previously in the literature, this review was conducted in an integrative manner; allowing for inclusion of diverse research designs. Results were synthesised narratively, with data categorised according to physical, psychological, and psychosocial indices of quality of life. The review protocol was registered in the international database of prospective systematic reviews in health and social care- (CRD42019137381).Results: Fifteen breast cancer and six prostate cancer articles were identified, each reporting one relevant study. Patients reported several negative issues at the time of a breast or prostate cancer recurrence. Similarities were found between cancer types, with physical problems such as fatigue, psychological issues including anxiety and depressive symptoms, and psychosocial concerns such as issues with healthcare professionals common in both cancers. Certain findings were inconsistent across studies, with some experiences differing between studies rather than due to cancer type.Conclusions: Differences in the experience of recurrent cancer appear to be more heavily influenced by individual factors, rather than cancer type. Findings are confounded by gender; and should be considered preliminary. Effects of recurrence should be studied in samples where cancer type and gender are not confounded. Concerns are raised about available study quality and differing outcome measures in this interpretation. Care and support of the individual at the time of a cancer recurrence is a key focus. Future research suggestions with implications for clinical practise are included.Systematic Review Registration: PROSPERO 2019 CRD42019137381.
An Exploratory Analysis of the Association Between Catechol-O-Methyltransferase and Response to a Randomized Open-Label Placebo Treatment for Cancer-Related Fatigue
Authors: Hoenemeyer Teri W. , Baidwan Navneet Kaur , Hall Kathryn , Kaptchuk Ted J. , Fontaine Kevin R. , Mehta Tapan S. 
Published: June 2021

Previous studies have identified catechol-O-methyltransferase (COMT), as a key enzyme influencing sympathetic function. Although the COMT SNP rs4680 and rs4818, are well-studied, little is known about their influence on cancer-related fatigue (CrF) and placebo response. In this study, we examined whether genetic variation in COMT, at the functional SNP rs4680 and linked rs4818, influenced open-label placebo (OLP) responses found in cancer survivors reporting moderate to severe CrF. We randomized cancer survivors (N = 74) reporting moderate-to-severe CrF to receive OLP or to treatment-as-usual (TAU) and assessed if rs4680 and rs4818 were associated with changes in fatigue severity and fatigue-distressed quality of life. At the end of the initial 21 days, the treatments were crossed over and both groups were re-assessed. Participants with the rs4680 high-activity G-allele (G/G or G/A) or rs4818 C/G genotypes reported significant decreases in fatigue severity and improvements in fatigue-distressed quality of life. The COMT rs4818 findings replicated findings in a similar study of OLP in cancer fatigue.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT02522988.
Social Class and Changes in Australian Women's Affect and Alcohol Consumption During COVID-19
Authors: Lunnay Belinda , Toson Barbara , Wilson Carlene , Miller Emma R. , Meyer Samantha Beth , Olver Ian N. , Foley Kristen , Thomas Jessica A. , Ward Paul Russell 
Published: June 2021

Introduction: Before the pandemic, mid-life women in Australia were among the “heaviest” female alcohol consumers, giving rise to myriad preventable health risks. This paper uses an innovative model of social class within a sample of Australian women to describe changes in affective states and alcohol consumption patterns across two time points during COVID-19.Methods: Survey data were collected from Australian mid-life women (45–64 years) at two time points during COVID-19—May 2020 (N = 1,218) and July 2020 (N = 799). We used a multi-dimensional model for measuring social class across three domains—economic capital (income, property and assets), social capital (social contacts and occupational prestige of those known socially), and cultural capital (level of participation in various cultural activities). Latent class analysis allowed comparisons across social classes to changes in affective states and alcohol consumption patterns reported at the two time points using alcohol consumption patterns as measured by the Alcohol Use Disorders Identification Test—Consumption (AUDIT-C) and its component items.Results: Seven social classes were constructed, characterized by variations in access to capital. Affective states during COVID-19 differed according to social class. Comparing between the survey time points, feeling fearful/anxious was higher in those with high economic and cultural capital and moderate social capital (“emerging affluent”). Increased depression was most prominent in the class characterized by the highest volumes of all forms of capital (“established affluent”). The social class characterized by the least capital (“working class”) reported increased prevalence of uncertainty, but less so for feeling fearful or anxious, or depressed. Women's alcohol consumption patterns changed across time during the pandemic. The “new middle” class—a group characterized by high social capital (but contacts with low prestige) and minimal economic capital—had increased AUDIT-C scores.Conclusion: Our data shows the pandemic impacted women's negative affective states, but not in uniform ways according to class. It may explain increases in alcohol consumption among women in the emerging affluent group who experienced increased feelings or fear and anxiety during the pandemic. This nuanced understanding of the vulnerabilities of sub-groups of women, in respect to negative affect and alcohol consumption can inform future pandemic policy responses designed to improve mental health and reduce the problematic use of alcohol. Designing pandemic responses segmented for specific audiences is also aided by our multi-dimensional analysis of social class, which uncovers intricate differences in affective states amongst sub-groups of mid-life women.
A Dialogue-Based System with Photo and Storytelling for Older Adults: Toward Daily Cognitive Training
Authors: Tokunaga Seiki , Tamura Kazuhiro , Otake-Matsuura Mihoko 
Published: June 2021

As the elderly population grows worldwide, living a healthy and full life as an older adult is becoming a topic of great interest. One key factor and severe challenge to maintaining quality of life in older adults is cognitive decline. Assistive robots for helping older adults have been proposed to solve issues such as social isolation and dependent living. Only a few studies have reported the positive effects of dialogue robots on cognitive function but conversation is being discussed as a promising intervention that includes various cognitive tasks. Existing dialogue robot-related studies have reported on placing dialogue robots in elderly homes and allowing them to interact with residents. However, it is difficult to reproduce these experiments since the participants’ characteristics influence experimental conditions, especially at home. Besides, most dialogue systems are not designed to set experimental conditions without on-site support. This study proposes a novel design method that uses a dialogue-based robot system for cognitive training at home. We define challenges and requirements to meet them to realize cognitive function training through daily communication. Those requirements are designed to satisfy detailed conditions such as duration of dialogue, frequency, and starting time without on-site support. Our system displays photos and gives original stories to provide contexts for dialogue that help the robot maintain a conversation for each story. Then the system schedules dialogue sessions along with the participant’s plan. The robot moderates the user to ask a question and then responds to the question by changing its facial expression. This question-answering procedure continued for a specific duration (4 min). To verify our design method’s effectiveness and implementation, we conducted three user studies by recruiting 35 elderly participants. We performed prototype-, laboratory-, and home-based experiments. Through these experiments, we evaluated current datasets, user experience, and feasibility for home use. We report on and discuss the older adults’ attitudes toward the robot and the number of turns during dialogues. We also classify the types of utterances and identify user needs. Herein, we outline the findings of this study, outlining the system’s essential characteristics to experiment toward daily cognitive training and explain further feature requests.
Livestock Network Analysis for Rhodesiense Human African Trypanosomiasis Control in Uganda
Authors: Okello Walter O. , Amongi Christine A. , Muhanguzi Dennis , MacLeod Ewan T. , Waiswa Charles , Shaw Alexandra P. , Welburn Susan C. 
Published: June 2021

Background:Infected cattle sourced from districts with established foci forTrypanosoma brucei rhodesiensehuman African trypanosomiasis (rHAT) migrating to previously unaffected districts, have resulted in a significant expansion of the disease in Uganda. This study explores livestock movement data to describe cattle trade network topology and assess the effects of disease control interventions on the transmission of rHAT infectiousness.Methods:Network analysis was used to generate a cattle trade network with livestock data which was collected from cattle traders (n= 197) and validated using random graph methods. Additionally, the cattle trade network was combined with a susceptible, infected, recovered (SIR) compartmental model to simulate spread of rHAT (Ro1.287), hence regarded as “slow” pathogen, and evaluate the effects of disease interventions.Results:The cattle trade network exhibited a low clustering coefficient (0.5) with most cattle markets being weakly connected and a few being highly connected. Also, analysis of the cattle movement data revealed a core group comprising of cattle markets from both eastern (rHAT endemic) and northwest regions (rHAT unaffected area). Presence of a core group may result in rHAT spread to unaffected districts and occurrence of super spreader cattle market or markets in case of an outbreak. The key cattle markets that may be targeted for routine rHAT surveillance and control included Namutumba, Soroti, and Molo, all of which were in southeast Uganda. Using effective trypanosomiasis such as integrated cattle injection with trypanocides and spraying can sufficiently slow the spread of rHAT in the network.Conclusion:Cattle trade network analysis indicated a pathway along whichT. b. rhodesiensecould spread northward from eastern Uganda. TargetedT. b. rhodesiensesurveillance and control in eastern Uganda, through enhanced public–private partnerships, would serve to limit its spread.
Poriella subacida Gen. & Comb Nov. for Perenniporia subacida (Peck) Donk
Authors: Chen Rui , Karunarathna Samantha C. , Zhao Chang-Lin 
Published: June 2021

Poriella subacida gen. & comb. nov., previously known as Perenniporia subacida, which causes white rot, has been documented in temperate and tropical forests. Specimens from Asia, North America, and Europe were examined, including the type specimen of Polylorus subacidus. Sequences of the ITS1-5.8S-ITS2 region, the 28S rDNA, the mitochondrial rDNA small subunit (mtSSU), and the gene encoding the translation elongation factor 1-α (EF1) were generated. In multigene phylogenies (maximum parsimony, maximum likelihood, Bayesian inferences), “Perenniporia subacida” formed a well-supported lineage, distinct from the core “Perenniporia” clade (type species: “P. medulla-panis”), and sister to the “Yuchengia narymica” lineage. We therefore conclude that “P. subacida” should be placed in the new genus “Poriella”gen. nov. Morphologically, “Poriella” is characterized by a di- to trimitic hyphal system, non-truncate basidiospores, and strongly dextrinoid, cyanophilic skeletal hyphae.
Solving the Longest Common Subsequence Problem Concerning Non-Uniform Distributions of Letters in Input Strings
Authors: Nikolic Bojan , Kartelj Aleksandar , Djukanovic Marko , Grbic Milana , Blum Christian , Raidl Günther 
Published: June 2021

The longest common subsequence (LCS) problem is a prominent NP–hard optimization problem where, given an arbitrary set of input strings, the aim is to find a longest subsequence, which is common to all input strings. This problem has a variety of applications in bioinformatics, molecular biology and file plagiarism checking, among others. All previous approaches from the literature are dedicated to solving LCS instances sampled from uniform or near-to-uniform probability distributions of letters in the input strings. In this paper, we introduce an approach that is able to effectively deal with more general cases, where the occurrence of letters in the input strings follows a non-uniform distribution such as a multinomial distribution. The proposed approach makes use of a time-restricted beam search, guided by a novel heuristic named Gmpsum. This heuristic combines two complementary scoring functions in the form of a convex combination. Furthermore, apart from the close-to-uniform benchmark sets from the related literature, we introduce three new benchmark sets that differ in terms of their statistical properties. One of these sets concerns a case study in the context of text analysis. We provide a comprehensive empirical evaluation in two distinctive settings: (1) short-time execution with fixed beam size in order to evaluate the guidance abilities of the compared search heuristics; and (2) long-time executions with fixed target duration times in order to obtain high-quality solutions. In both settings, the newly proposed approach performs comparably to state-of-the-art techniques in the context of close-to-uniform instances and outperforms state-of-the-art approaches for non-uniform instances.
The role of family communication in shaping the quality of adult sibling interpersonal relationships and the opinions about the social world
Authors: Walęcka-Matyja Katarzyna Kamila 
Published: June 2021

The aim of the study was to determine the relationships between the dimensions of the quality of the interpersonal relationship of siblings in early adulthood and opinions about the social world, and to check whether there are relational predictors of these opinions.
The participants of the study were 180 people (including 48.9% women) who were in early adulthood (M = 24.73; SD = 4.54), who came from complete families with adult siblings.
The following research tools were used: the Adult Relationship Questionnaire (Walęcka-Matyja, 2014), the STQ-Now Questionnaire (Szymańska, 2016), the Social Opinion Questionnaire (Różycka, Wojciszke 2010) and a questionnaire.
The obtained results indicate the existence of numerous, although mostly weak and moderate, relationships in the expected directions between all dimensions of the interpersonal relationship of siblings (except for Competition) and opinions about the social world. Relational predictors of beliefs about the social world were also determined. It was found that sibling relationships in which there is high conflict, intense competition and indifference negatively affect the experience of satisfaction with social exchange, the level of self-esteem and trust in interpersonal contacts. Additionally, the negative aspects of the relationship of adult siblings (Conflict, Indifference) foster the belief that the world is a game in which you have to be ready to constantly fight with others. In turn, friendly relations between siblings (Warmth, Mutuality) and those with an element of struggle for power in the relationship (Domination) contributed to an increase in the level of self-esteem.
OS BENEFÍCIOS DA SEGURIDADE SOCIAL SEGUNDO OS MOLDES DO ORDENAMENTO JURÍDICO BRASILEIRO
Authors: José Araujo Avelino  , Ana Flávia Santos de Sousa  , Carolina Souza Ferraz  , Giseli Lima Ferreira de Jesus  , Gustavo de Souza Lefundes  , Luana Silva Conceição  , Micaele Mota Lima  
Published: June 2021

Este trabalho propõe uma discussão a respeito das características dos benefícios da Seguridade Social previstos no ordenamento jurídico brasileiro, onde, são abordados os princípios constitucionais da Seguridade Social, analisando a aplicação dos direitos fundamentais de seguridade social, bem como, discutimos a evolução jurisprudencial dos benefícios da seguridade social. No segundo momento, apresentamos as características dos benefícios da seguridade social e sua aplicabilidade, tendo como metodologia por meio da revisão bibliográfica, obtido através da pesquisa empírica, com suporte da legislação.
Tipos de ensayos clínicos con asignación aleatoria publicados en PubMed durante 40 años
Authors: Martínez Franco Mariana , Nirta Pérez Antonio Roberto , Donado Gómez Jorge Hernando 
Published: June 2021

Introducción: existen múltiples variantes del ensayo clínico aleatorizado; según diseño: grupos paralelos, cruzado, factorial, asignación por grupos, N de 1, pareado, retiro, adaptativo y pragmático; y por propósito: superioridad, no inferioridad y equivalencia. Debido a esta heterogeneidad, en 1996 se introdujo el CONSORT (Consolidated Standards of Reporting Trials) para suministrar una guía para el reporte de los ensayos clínicos aleatorizados.
Objetivo: describir la tendencia de publicación de los tipos de ensayos clínicos aleatorizados durante 40 años, en relación con la publicación del CONSORT y sus extensiones.
Métodos: se utilizó la herramienta PubMed para realizar una búsqueda de ensayos clínicos aleatorizados publicados entre 1979 y 2018, discriminándolos según las variantes descritas.
Resultados: se encontraron 472 114 artículos publicados, el 90.2% no reportó tipo de diseño y 98.2% no reportó propósito. Entre los artículos que reportaron la variante de ensayos clínicos aleatorizados, el diseño predominante fue el cruzado (5.9%), seguido por grupos paralelos (2.34%); mientras que el propósito más frecuente fue el de superioridad (0.84%). Hubo un aumento en la proporción de artículos por variante publicados después del lanzamiento del CONSORT para los diseños de: grupos paralelos; diferencia de proporciones 1.89 IC 95% (1.1-2.7); pareado 1.07 IC 95% (0.2-1.9); pragmático 4.73 IC 95% (4.4-5.1); y para el propósito de no inferioridad 5.97 IC 95% (5.6-6.3).
Discusión: la mayoría de los artículos sobre ensayos clínicos aleatorizados no mencionan en su título y resumen la variante de estos. La proporción de artículos que sí lo hicieron, aumentó discretamente después de la publicación del CONSORT