bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modest wear e-commerce: examining online purchase intent in Indonesia
Authors: Sumarliah Eli , Khan Sher Zaman , Khan Rafi Ullah 
Published: June 2021

Purpose
The study has three primary purposes, i.e. (1) to examine the determinants influencing customers’ online purchase intent for modest wear; (2) to measure the effects of electronic innovativeness, fashion innovativeness, perceived value, and trust on the intent to buy modest wear via the Internet; (3) to inspect how the factor “trust” can affect the “perceived value” of modest wear purchase through e-commerce; and (4) to explore the roles of “attitude” and “religiosity” in influencing customers’ intent to purchase modest wear online.

Design/methodology/approach
561 Muslim consumers were reviewed in the study. According to the conceptual framework established through a literature review on the constructs suggested, measurement items were modified to the study’s perspective, and a 31-item questionnaire was applied. A regression examination of potential variables was applied using ADANCO version 2.0.1 software and the PLS-SEM.

Findings
The findings signify that the leading factors affecting online modest wear purchase intent are fashion innovativeness, electronic innovativeness, perceived value, trust, attitude, and religiosity. Meanwhile, trust is the predictor of perceived value, and religiosity is the predictor of attitude.

Originality/value
There are only two notable studies that focus on modest fashion purchase intention in the online channel with examining only three influential factors. The study is an initial effort to examine new and more complete leading factors affecting online modest wear purchase intent including fashion innovativeness, electronic innovativeness, perceived value, trust, attitude, and religiosity.
Does board independence moderate the effect of politician directors on CSR disclosure? Evidence from the publicly listed banks in Bangladesh
Authors: Rashid Md. Harun Ur , Hossain Syed Zabid 
Published: June 2021

PurposeThis study aims to investigate the moderating effect of independent directors on the relationship between politicians on the board and corporate social responsibility disclosure (CSRD).Design/methodology/approachThe ordinary least square has been used to analyze the CSRD data collected from the annual reports of all 30 listed banks of Bangladesh covering six years period ranging from 2013–2018. Further, the study has applied the generalized method of moments to prove the robustness of the model across the endogeneity issue.FindingsThe study found a positive relationship between board independence and CSRD that indicates board independence enhances the CSRD to a great extent. On the contrary, the inclusion of politicians on the board has shown a negative impact on CSRD that implies the higher the presence of political members on the board of a bank, the lower the involvement of the bank in CSR activities. However, board independence positively and significantly moderates the politician directors on the CSRD. The findings imply that if the independent directors are empowered, they play the role of whistleblowers that, in turn, mitigates the negative role of politician directors to CSRD.Research limitations/implicationsThe study suggests the banks’ management, and regulatory bodies formulate sound policies so that the banks are forced to include more independent directors with enough power and at the same time, reduce the politician directors on the board.Originality/valueThe study extends debate on the political CSR and CSRD through validating the role of board independence.
Associations between peripheral perfusion disorders, mean arterial pressure and dose of norepinephrine administrated in the early phase of septic shock
Authors: Magnin Mathieu , Amson Harry , Vacheron Charles‐Hervé , Thiollière Fabrice , Piriou Vincent , Junot Stéphane , Bonnet Garin Jeanne‐Marie , Allaouchiche Bernard 
Published: June 2021

AbstractThe aim of the study was to explore the correlations between peripheral perfusion, mean arterial pressure and the dose‐rate of norepinephrine (NE) infused for the treatment of septic shock. The study is retrospective analysis of data acquired prospectively on 57 patients during the first 24 hours after the occurrence of the shock. Clinical and haemodynamic characteristics, skin perfusion parameters (capillary refill time [CRT], mottling score and temperature gradients) and the dose rate of NE infusion were collected. Negative correlations between mean arterial pressure (MAP) and temperature gradients (core‐to‐toe: P = .03, core‐to‐index: P = .04) were found and abnormal CRT was associated with lower MAP (P = .02). The dose rate of NE was negatively correlated with temperature gradients (core‐to‐toe: P = .02, core‐to‐index: P = .01, forearm‐to‐index: P = .008) in the overall population. In patients receiving NE for at least 12 hours, the NE dose rate positively was correlated with the mottling score (P = .006), temperature gradients (core‐to‐toe: P = .04, forearm‐to‐index: P = .02, core‐to‐index: P = .005) and CRT (P = .001). The dose of NE administrated was associated with 14‐days mortality (odds ration [OR] = 1.21 [1.06‐1.38], P = .006) and with 28‐days mortality (OR = 1.17 [1.01‐1.36], P = 0.04). In conclusion, the study described the presence of correlations between peripheral perfusion and MAP and between peripheral perfusion and the dose rate of NE infusion.
Chromosome‐scale genome assembly of areca palm (Areca catechu)
Authors: Yang Yaodong , Huang Liyun , Xu Chunyan , Qi Lan , Wu Zhangyan , Li Jia , Chen Haixin , Wu Yi , Fu Tao , Zhu Hui , Saand Mumtaz Ali , Li Jing , Liu Liyun , Fan Haikou , Zhou Huanqi , Qin Weiquan 
Published: June 2021

AbstractAreca palm (Areca catechu L.; family Arecaceae) is an important tropical medicinal crop and is also used for masticatory and religious purposes in Asia. Improvements to areca properties made by traditional breeding tools have been very slow, and further advances in its cultivation and practical use require genomic information, which is still unavailable. Here, we present a chromosome‐scale reference genome assembly for areca by combining Illumina and PacBio data with Hi‐C mapping technologies, covering the predicted A. catechu genome length (2.59 Gb, variety “Reyan#1”) to an estimated 240× read depth. The assembly was 2.51 Gb in length with a scaffold N50 of 1.7Mb. The scaffolds were then further assembled into 16 pseudochromosomes, with an N50 of 172 Mb. Transposable elements comprised 80.37% of the areca genome, and 68.68% of them were long‐terminal repeat retrotransposon elements. The areca palm genome was predicted to harbour 31,571 protein‐coding genes and overall, 92.92% of genes were functionally annotated, including enriched and expanded families of genes responsible for biosynthesis of flavonoid, anthocyanin, monoterpenoid and their derivatives. Comparative analyses indicated that A. catechu probably diverged from its close relatives Elaeis guineensis and Cocos nucifera approximately 50.3 million years ago (Ma). Two whole genome duplication events in areca palm were found to be shared by palms and monocots, respectively. This genome assembly and associated resources represents an important addition to the palm genomics community and will be a valuable resource that will facilitate areca palm breeding and improve our understanding of areca palm biology and evolution.
A meta‐regression of methodological features that predict the effects of medications on the subjective response to alcohol
Authors: Green ReJoyce , Du Han , Grodin Erica N. , Nieto Steven J. , Bujarski Spencer , Roche Daniel J.O. , Ray Lara A. 
Published: June 2021

AbstractBackgroundAlcohol administration paradigms have been used for early efficacy testing of novel compounds for alcohol use disorder (AUD). There has been an ongoing debate about sample characteristics and methodological features that affect the likelihood of detecting an early efficacy signal for AUD medications. We conducted a meta‐regression to test whether the drinking level of the study sample and the peak breath alcohol concentration (BrAC) in the alcohol administration study predict the efficacy of AUD pharmacotherapies on the subjective responses to alcohol.MethodsWe computed the effects of 21 medications on alcohol‐induced stimulation, sedation, negative mood, and craving during alcohol administration in 49 studies.ResultsMeta‐regression analyses indicated a significant and positive effect of pre‐study drinks per month on alcohol‐induced stimulation (β = 0.142, p < 0.0001), such that as drinking increases, the benefit of medication over placebo decreases. There was an effect of drinks per month on negative mood (β = −0.164, p = 0.0248), such that at higher levels of drinks per month, the effects of medications on negative mood are stronger. For sedation, there was an effect of peak BrAC (β = 0.119, p = 0.0002), such that at low levels of peak BrAC, the effects of medication on sedation were null. For craving, there was a peak BrAC × drinks per month interaction such that at low levels of BrAC, a heavier drinking sample is required to detect the effects of medication on craving. Sensitivity analyses comparing naltrexone studies and non‐naltrexone studies suggested that naltrexone was less sensitive to drinks per month across subjective response domains.ConclusionsThese analyses show that design features are critical in studies that test the effects of medications on the subjective responses to alcohol. By specifying the significance and directionality of these effects, as well as the specific points in BrAC or drinks per month at which medication effects are detectable, the study offers recommendations for design features of alcohol administration studies that aim to inform AUD medication development.
Altered effective connectivity of the reward network during an incentive‐processing task in adults with alcohol use disorder
Authors: Arias Albert J. , Ma Liangsuo , Bjork James M. , Hammond Christopher J. , Zhou Yi , Snyder Andrew , Moeller Frederick Gerard 
Published: June 2021

AbstractBackgroundAbnormalities of reward sensitivity and impulsivity are known to be correlated with each other and alcohol use disorder (AUD) risk, but the underlying aberrant neural circuitry involved is not clearly defined. We sought to extend the current knowledge of AUD pathophysiology by studying incentive processing in persons with AUD using functional neuroimaging data.MethodsWe utilized functional MRI data from the Human Connectome Project Database obtained during performance of a number‐guessing incentive‐processing task with win, loss, and neutral feedback conditions in 78 participants with either DSM‐IV alcohol abuse or dependence (combined as the AUD group) and 78 age‐ and sex‐matched control (CON) participants. Within a network consisting of anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), insula, ventral striatum, and dorsal striatum (DS) in the right hemisphere, we performed dynamic causal modeling analysis to test group‐level differences (AUD vs. CON) in effective directional connectivity (EC) as modulated by “win” and “loss” conditions. We used linear regression analyses to characterize the relations between each EC outcome and measures of cumulative alcohol exposure and impulsivity.ResultsDuring wins, AUD participants had lower ECs from ACC to the other four nodes, greater ECs from insula to the other four nodes, greater ECs from DLPFC to the other four nodes, and greater DS to DS self‐connection EC than CON participants. In the total sample, EC from the insula to the DLPFC (insula → DLPFC) during wins was positively correlated with both impulsivity (as measured by the delay‐discounting task) and cumulative alcohol exposure. The DS to DS self‐connection EC during wins was positively correlated with impulsivity. Many of the altered ECs from the ACC and insula to other nodes were correlated with cumulative alcohol exposure.ConclusionsIndividuals with AUD have disrupted EC in both instrumentally driven and automatized corticostriatal reward circuits during non‐alcohol reward feedback. These results point to disrupted corticostriatal EC in both “top‐down” and “bottom‐up” pathways among individuals with AUD.
Regionally specific gray matter volume is lower in alcohol use disorder: Implications for noninvasive brain stimulation treatment
Authors: McCalley Daniel M. , Hanlon Colleen A. 
Published: June 2021

AbstractBackgroundThere is growing interest in neuromodulation‐based therapeutics as tools for individuals with alcohol use disorder (AUD). Through electromagnetic induction, techniques such as transcranial magnetic stimulation (TMS) can noninvasively depolarize cortical cells in the induced electrical field and monosynaptic afferents. The ability of TMS to modulate the brain is dependent upon two factors, which may be compromised in individuals with AUD: (1) gray matter volume (GMV) at the site of stimulation and (2) scalp‐to‐cortex (STC) distance. This study tested the hypotheses that these aspects of neural architecture are compromised in AUD patients, and thus AUD patients may need a higher TMS dose to depolarize the cortex.MethodsHigh‐resolution magnetic resonance images were acquired from 44 individuals with AUD and 44 age‐matched healthy controls (n = 88). Whole‐brain voxel‐based morphometry was conducted. Subsequent region‐of‐interest analysis was performed at three EEG 10‐20 sites commonly used in TMS for AUD: FP1 (left frontal pole), F3 (left DLPFC), and C3 (left motor cortex). STC distance and TMS electric fields were assessed at these EEG sites.ResultsIndividuals with AUD had significantly lower GMV in the bilateral orbitofrontal cortices, supramarginal gyri, and the left DLPFC (voxel‐threshold p < 0.05, cluster‐threshold p < 0.05) and within all 3 TMS target locations, F (1, 264) = 14.12, p = 0.0002. There was no significant difference in STC distance between the AUD and the healthy control group at any tested cortical location, F (3, 252) = 1.906, p = 0.129.ConclusionsIndividuals with AUD had significantly lower GMV in multiple areas of interest for TMS treatment; however, these volumetric reductions did not impact STC distance. Given previous studies that have shown TMS‐evoked changes in cortical and subcortical activity to be dependent on GMV, these data suggest that individuals with AUD may require higher doses of TMS to sufficiently modulate the neural circuits of interest.
Genome‐wide SNP analysis clearly distinguished the Belarusian Red cattle from other European cattle breeds
Authors: Zinovieva N. A. , Sheiko I. P. , Dotsev A. V. , Sheiko R. I. , Mikhailova M. E. , Sermyagin A. A. , Abdelmanova A. S. , Kharzinova V. R. , Reyer H. , Wimmers K. , Sölkner J. , Pleshanov N. V. , Brem G. 
Published: June 2021

SummaryLocal breeds can serve as an important source of genetic variability in domestic animal species. This study aimed to assess the genetic diversity and population structure of Belarusian Red cattle and their differentiation from other European cattle populations based on genome‐wide SNP genotypes. Twenty pedigree‐recorded non‐closely related cows of Belarusian Red cattle were genotyped using the Illumina BovineHD BeadChip. Genotypes of 22 other European cattle breeds were included in the study for comparison. A total of 28 562 SNPs passed through the quality control checks and were selected for analysis. The Belarusian Red cattle displayed a moderate level of genetic variability (UHE = 0.341, HO = 0.368), and the highest heterozygote excess (UFIS = −0.066), among the studied breeds; this reflects the contribution of multiple breeds to their formation. The principal component analysis, FST‐based Neighbor‐Net tree and Admixture clustering, clearly distinguished the Belarusian Red cattle from the other European cattle breeds. Moreover, the presence of ancestral genomic components of Danish Red and Brown Swiss breeds were clearly visible, which agrees with the breed's history and its recent development. Our study highlights the importance of maintaining the specific genomic components, which makes a significant contribution to the global genetic diversity in the modern population of Belarusian Red cattle, allowing us to consider them a valuable national genetic resource. Our research results will be useful for the development of conservation programs for this local cattle breed.
Is Justice a Fixed Point?
Authors: Schaefer Alexander 
Published: June 2021

AbstractFollowing the work of John Rawls, political theorists have fixated on the comparative stability of different equilibrium states of justice. This article identifies a crucial gap in this literature, namely, the lack of attention paid to nonequilibrating systems. Drawing on Kakutani's theorem, I present plausible cases in which society will fail to exhibit any equilibrium states of justice. An important implication for political theory is that, rather than focusing exclusively on stable equilibria, theorists should examine dynamic processes of justice, which need not exhibit equilibrating forces. To this end, a concept more useful than stability is that of robustness, or the ability of a system to maintain general desiderata in the face of an evolving conception of justice.
Distinct contribution of hyperbaric oxygen therapy to human neutrophil function and antibiotic efficacy against Staphylococcus aureus
Authors: Schwartz Franziska A. , Lerche Christian J. , Christophersen Lars , Jensen Peter Østrup , Laulund Anne Sofie , Woetmann Anders , Høiby Niels , Moser Claus 
Published: June 2021

AbstractStaphylococcus aureus (SA) causes superficial and severe endovascular infections. The present in vitro study investigates the anti‐SA mechanisms of hyperbaric oxygen therapy (HBOT) on direct bacterial killing, antibiotic potentiation, and polymorphonuclear leukocyte (PMN) enhancement. SA was exposed to isolated human PMNs, tobramycin, ciprofloxacin, or benzylpenicillin. HBOT was used as one 90‐min session. Bacterial survival was evaluated after 4 h by quantitative bacteriology. PMN functionality as reactive oxygen species (ROS) production was measured by means of dihydrorhodamine 123 analysis. We showed that HBOT exhibits significant direct anti‐SA effects. HBOT increased the anti‐SA effects of PMNs by 18% after PMA stimulation (p = 0.0004) and by 15% in response to SA (p = 0.36). HBOT showed an additive effect as growth reductions of 26% to sub‐MICs of tobramycin (p = 0.0057), 44% to sub‐MICs of ciprofloxacin (p = 0.0001), and 26% to sub‐MICs of penicillin (p = 0.038). The present in vitro study provides evidence that HBOT has differential mechanisms mediating its anti‐SA effects. Our observation supports the clinical possibility for adjunctive HBOT to augment the host immune response and optimize the efficacy of antibiotic treatments.
Diagnostic utility of the combined use of HNF4A and GATA3 in distinction between primary and metastatic breast and gastric carcinomas
Authors: Saad Diana Z. , Sidhom Karima F. , Gadallah Manal F. , Samir Naglaa A. , Shakweer Marwa M. 
Published: June 2021

AbstractSometimes the distinction between gastric adenocarcinomas and breast carcinomas can be challenging. Hepatocyte nuclear factor 4‐alpha (HNF4A) has been suggested as a potential marker in these cases. The aim of the present work was to evaluate the role of the combined use of HNF4A and GATA3 as immunohistochemical markers in distinction between primary and metastatic breast and gastric carcinomas. This retrospective study was conducted on (81) cases divided into four groups of cohorts: primary BC (cohort I, n = 25), primary GC (cohort II, n = 23), and metastases derived from both types of tumors designated as metastasis derived from BC (cohort III‐A, n = 17) and metastasis derived from GC (cohort III‐B, n = 16). We performed immunohistochemistry analysis of HNF4A and GATA3 in all (81) cases. HNF4A expression was seen in 22 of 23 primary gastric adenocarcinomas and was absent in all 25 primary breast carcinomas (sensitivity 95.7%, specificity 100%). HNF4A was seen in 15 of 16 metastatic gastric adenocarcinomas and was absent in all 17 metastatic breast carcinomas (sensitivity 93.8%, specificity 100%). GATA3 showed 92 and 88% sensitivity, and 95.7 and 100% specificity for primary breast carcinomas and metastatic breast carcinomas, respectively. Our data confirmed the potential utility of HNF4A as a diagnostic marker and can be used as an adjunct to GATA3 as an immunohistochemical panel to differentiate between breast and gastric carcinomas.
Shifts in the humanitarian space? Examining NGO–military engagements during the 2017 crisis in Marawi, Philippines
Authors: Hall Rosalie Arcala , Deinla Imelda 
Published: June 2021

AbstractThe increase in military deployments for operations other than war, and their co‐location with humanitarian actors prompt an examination of how operational engagements are blurring boundaries between the two. Military‐initiated coordination structures that bridge civilian and military spheres of activities are seen as signs of the securitization of the humanitarian space. Examining the dynamics between deployed Philippine military units and local non‐governmental organizations (NGOs) in the humanitarian response to the 2017 Marawi siege, the former physically separated and subsumed humanitarian actions to kinetic goals. Using data from 48 interviews of commanders, NGO representatives and local government officials in 2018‐2019, military‐NGO interface was limited by military restrictions on mobility and by having a separate coordination platform benefiting soldiers and evacuees, respectively. Humanitarian NGOs are more willing to work with and are differential to the securitized space compared to human rights‐based NGOs.
Time to rethink haemoglobin threshold guidelines in sickle cell disease
Authors: Ballas Samir K. , Kuypers Frans A. , Gordeuk Victor R. , Hankins Jane S. , Thompson Alexis A. , Vichinsky Elliott 
Published: June 2021

SummaryAlleviating anaemia in patients with sickle cell disease (SCD) is crucial in managing acute complications, mitigating end‐organ damage and preventing early mortality. Some disease‐modifying and curative therapies have increased haemoglobin (Hb) levels to exceed 100 g/l, a threshold above which complications from red blood cell (RBC) transfusions have occurred, raising concern about whole‐blood viscosity‐related complications with these therapies. Here we discuss the rationale behind this limit, the effect of viscosity on blood flow and the applicability of this Hb threshold to therapies for SCD beyond RBC transfusions.