bluuebunny/crossref_metadata_2025_split huggingface dataset:
Willingness to communicate in a second language and the promise of complex dynamic systems theory: A narrative review
Authors: Syed Hassan , Memon Shumaila , Chachar Zulfiqar Ali , Zameer Sharique , Shah Tanweer 
Published: July 2021

Willingness to communicate in a second language (L2 WTC) is a speaker’s voluntary engagement in communication using a target language. WTC has undergone several conceptualisations over the past twenty years or so. The aim of the current article is to present a narrative review of the major conceptual developments in research on L2 WTC. First, the article discusses the strengths and limitations of the major conceptualizations of L2 WTC, i.e. MacIntyre et al. pyramid model, Wen and Clement Chinese conceptualization, and Kang’s situational model of L2 WTC. Second, the article presents the basic features of the complex dynamic systems theory (CDST) and discusses how it serves as a meta-theory with immense explanatory power to encompass the complex, dynamic and non-linear behaviour of L2 WTC. Finally, corresponding to a CDST construal of L2 WTC, the paper discusses some of the methodological developments and possible directions for future research. The article aims to contribute to language teachers’ and teacher educators’ awareness of the complex and dynamic nature of L2 WTC and provide future researchers with an alternative theoretical framework and corresponding methods to study L2 WTC.
Atypical use of PICC as centrally inserted central catheter in infants and neonates: Report of a 10-year experience
Authors: Nourzaie Romman , Abbas Hiba , Parthipun Aneeta , Boolkah Soo , Ahmed Irfan , Gkoutzios Panos , Moser Steven , Monzon Leonard , Karunanithy Narayan , Diamantopoulos Athanasios 
Published: July 2021

Purpose: The aim was to determine the success, safety and post procedure complications of peripherally inserted central catheters as centrally inserted central catheters (CICC). Materials and method: One hundred and sixty-one consecutive infants and neonates, who underwent image guided tunnelled central venous catheter insertion were retrospectively evaluated between April 2008 and April 2018. Patient’s demographics, site of access and procedure details were recorded. Outcomes included technical success and post procedure complications. Results: One hundred and eighty-two CICCs were inserted in 161 patients (49.7%, n = 80 male). Mean patient age was 100 days (range: 0–342) with a mean weight of 4.20 kg (range 1.80–9.40). The most common indication was for antibiotics administration (41%; n = 66). Technical success was 99% (181/182). Early complications (<7 days) were seen in 8.8% ( n = 13). This included inadvertent line removal in 5.5%, catheter-related bloodstream infection in 1.1% and catheter occlusion in 2.2% ( n = 4). Average line functional duration prior to removal was 26 days (range 0–180). 77.5% of the lines lasted for the intended duration of treatment. In the neonate subgroup, 84.1% (37/44 lines) of lines remained in situ for the intended duration of treatment. Conclusion: Tunnelled central venous catheters using non-cuffed peripherally inserted central catheters in infants is a safe technique with excellent success rate and minimal complications rates.
The effect of PECS-1 block on postoperative pain in total implantable venous access port catheter (TIVAP) insertion
Authors: Pişkin Özcan , Altınsoy Bülent , Baytar Çağdaş , Aydın Bengü Gülhan , Okyay Dilek , Küçükosman Gamze , Bollucuoğlu Keziban , Yılmaz Alkım Gizem , Ayoğlu Hilal 
Published: July 2021

Background: The aim of this prospective, randomized, controlled study was to evaluate the analgesic effect of US-guided Pectoral (PECS) I blocks on postoperative analgesia after TIVAP insertion. Methods: A hundred-twenty patients were included in this study. The patients were divided into two groups: Group PECS and Group INF (infiltration). A total 0.4 mL kg−1 0.25% bupivacaine was injected to below the middle of the clavicle in the interfascial space between the pectoralis major and minor muscles for PECS-1. The skin and deep tissue infiltration of the anterior chest wall was performed with 0.4 mL kg−1 0.25% bupivacaine for INF group. Tramadol and paracetamol consumption, visual analog scale pain scores were recorded at 0, 1, 4, 12, and 24 h postoperatively. Results: The use of the PECS in TIVAP significantly decreased the amount of paracetamol used in the first 24 h postoperatively ( p < 0.001). There was a statistically significant difference in the number of tramadol rescue analgesia administered between the groups ( p < 0.001) There was no significant difference between the groups in terms of the VAS scores at 0 and 24 h. However, VAS scores at 1, 4, and 12 h were found to be significantly lower in patients who underwent PECS than in those who received infiltration anesthesia ( p < 0.001). Conclusions: This study shows that US-guided PECS-1 provides adequate analgesia following TIVAP insertion as part of multimodal analgesia. The PECS-1 significantly reduced opioid consumption.
Biscriptal bilingualism differentially affects segmentation of cross-language homophones: Evidence from Hindi and English users
Authors: Vaid Jyotsna , Chen Hsin-Chin , Rao Chaitra 
Published: July 2021

Aims and objectives: Few previous studies of bilingual cognition have theorized the impact of being literate in distinct orthographies. This study examined: (1) How do differences in the way writing systems represent sound affect biscriptal bilinguals’ segmentation of spoken words in each language? and (2) What is the impact of the first learned orthography? These questions were addressed in native and non-native readers of Hindi and English. The primary unit of writing in Hindi is the akshara, which corresponds to a syllable in most cases, whereas for English the unit of writing corresponds to a phoneme. Method: Hindi-English users listened to cross-language homophones in Hindi and English. Participants were instructed to take away “the first sound” of each word and say aloud what remained. Data analysis: Percent deletion of the initial phoneme was examined. Exp. 1 included 44 bilinguals. Exp. 2 tested 13 bilinguals. Findings/conclusions: For native English readers the first phoneme was deleted regardless of language. For native readers of Hindi, performance differed by language: the “first sound” was a phoneme for English words but a syllable for Hindi words (except for vowel-initial words). Originality: Using a novel paradigm, this study demonstrates that biscriptal bilinguals’ conceptions of speech sounds are differentially shaped by their knowledge of the written forms of those sounds: deleting “the first sound” in /sʌfʌr/ resulted in /fʌr/ when it was presented as a Hindi word but as /ʌfʌr/ when presented as English. Thus, the very same spoken word can yield different conceptions depending on whether it is heard as a word belonging to one language or another. Significance/implications: The findings indicate that language-specific orthographic knowledge influences biscriptal bilinguals’ conceptualization of speech sounds in their respective languages. More generally, our study argues for more research on biscriptal bilinguals in the study of bilingual cognition.
Evidence of phonological transfer in bilingual preschoolers who speak Arabic and French
Authors: Meziane Rabia Sabah , MacLeod Andrea AN 
Published: July 2021

Purpose: The purpose of this study is to document evidence of phonological transfer in bilingual preschoolers. Specifically, we focus on the phonological development of bilingual children acquiring French and Arabic. Method: Nine children who spoke Arabic and French, aged three years old, participated in a picture-naming task in both languages. Three types of measurement were used to examine the interaction between the two systems: consonants accuracy; inventory of acquired consonants; and types of errors. Data and analysis: The accuracy of shared and unshared consonants between Arabic and French were compared with a repeated measures analysis of variance, and error patterns were analyzed. Conclusions: Two main results suggest that these bilingual children have two phonological systems that interacted. First, the children had an inventory of acquired consonants that differed according to language. Second, they produced shared consonants more accurately than unshared consonants, indicating positive interactions and low accuracy for unshared consonants, indicating negative interactions. Originality: This study contributes much-needed research relating to the development of bilingual children, particularly children who are acquiring Arabic and French. Implications: These findings enrich the understanding of bilingual phonological development and contribute to understanding how two phonological systems interact. This study also has clinical implications for evaluation and intervention with bilingual children.
Prognostic Value of Tumor Infiltrating Lymphocytes in Nasopharyngeal Carcinoma Patients: Meta-Analysis
Authors: Berele Birhanu Aberha , Cai Yuxiang , Yang Guifang 
Published: July 2021

Objective: To evaluate the prognostic value of tumor infiltrating lymphocytes (TILs) in nasopharyngeal carcinoma (NPC) patients. Method: Meta-analysis was performed on eligible studies that was identified by systematic searching of Google scholar, MEDLINE, CNKI, Scopus, PubMed, PMC, Embase and Web of Science databases. The study protocol was registered in International Platform of Registered Systematic Review and Meta-Analysis Protocols-INPLASY (registration number: INPLASY202160014). Databases were searched from inception to January 20, 2020 to identify eligible studies. Those studies that evaluated survival in the form of hazard ratio (HR) in TILs of NPC patients was analyzed. All statistical analysis was performed by using STATA version 16.0 software. Result: Fourteen studies with a total of 3025 patients was analyzed. The pooled result showed that high TILs was significantly associated with favorable overall survival (OS) (HR = 0.55; 95%CI = 0.39-0.77; P = 0.001) and disease free survival (DFS) (HR = 0.60; 95%CI = 0.44-0.81; P = 0.04). Interestingly, high intratumoral TILs had relatively better OS (HR = 0.45; 95%CI = 0.35-0.58; P = 0.006) than stromal TILs (HR = 0.59; 95%CI = 0.36-0.97; P = 0.03). Moreover, an increased level of CD4+ cells infiltration was correlated with favorable OS (HR = 0.4; 95%CI = 0.18-0.85; P = 0.01). CD3+, CD8+ and FoxP3+ lymphocyte’s better prognosis was not statistically significant for OS ( P = 0.09; P = 0.07; P = 0.52) and for DFS ( P = 0.13; P = 0.29) respectively. However, subgroup analysis of intratumoral CD3+ (HR = 0.48; 95%CI = 0.33-0.70; P = 0.05) and intratumoral CD8+ (HR = 0.32; 95%CI = 0.16-0.62; P = 0.001) was significantly associated with improved OS, but not significant in stromal CD3+ (HR = 0.66; 95%CI = 0.20-2.20; P = 0.62). Conclusion: TILs were variably correlated with better prognosis depending on their microanatomic location and subset of TILs in NPC patients. CD4+, intratumoral CD3+ and intratumoral CD8+ lymphocytes could predict favorable patient outcome which suggest that their role in mediating antitumor immune response could potentially be exploited in the treatment of NPC patients. Future large study on the prognostic value of microanatomic location of TILs is needed for confirmation.
Near-infrared fluorescence imaging with indocyanine green for quantification of changes in tissue perfusion following revascularization
Authors: Van den Hoven Pim , S Weller Floris , Van De Bent Merel , Goncalves Lauren N , Ruig Melissa , D Van Den Berg Simen , Ooms Sophie , Mieog JSD , EA Van De Bogt Koen , Van Schaik Jan , Schepers Abbey , Vahrmeijer Alex L , Hamming Jaap F , Van Der Vorst Joost R 
Published: July 2021

Objectives Current diagnostic modalities for patients with peripheral artery disease (PAD) mainly focus on the macrovascular level. For assessment of tissue perfusion, near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) seems promising. In this prospective cohort study, ICG NIR fluorescence imaging was performed pre- and post-revascularization to assess changes in foot perfusion. Methods ICG NIR fluorescence imaging was performed in 36 patients with PAD pre- and post-intervention. After intravenous bolus injection of 0.1 mg/kg ICG, the camera registered the NIR fluorescence intensity over time on the dorsum of the feet for 15 min using the Quest Spectrum Platform®. Time-intensity curves were plotted for three regions of interest (ROI): (1) the dorsum of the foot, (2) the forefoot, and (3) the hallux. Time-intensity curves were normalized for maximum fluorescence intensity. Extracted parameters were the maximum slope, area under the curve (AUC) for the ingress, and the AUC for the egress. The non-treated contralateral leg was used as a control group. Results Successful revascularization was performed in 32 patients. There was a significant increase for the maximum slope and AUC egress in all three ROIs. The most significant difference was seen for the maximum slope in ROI 3 (3.7%/s to 6.6%/s, p < 0.001). In the control group, no significant differences were seen for the maximum slope and AUC egress in all ROIs. Conclusions This study shows the potential of ICG NIR fluorescence imaging in assessing the effect of revascularization procedures on foot perfusion. Future studies should focus on the use of this technique in predicting favorable outcome of revascularization procedures.
Our experience in laparoscopic ureterolysis and omental wrapping as a definitive surgical management of ureteric obstruction related to retroperitoneal fibrosis
Authors: Uddin MM , Varley R , Napier-Hemy RD 
Published: July 2021

Introduction and Objectives: Retroperitoneal fibrosis (RPF) is a rare fibro-inflammatory disease and a cause of ureteric obstruction that leads to obstructive uropathy. Although the mainstay of RPF treatment is medical, ureterolysis becomes a necessity if medical treatment fails or if patients are unable to tolerate side effects of conservative/medical management, including those of ureteric stents. We aimed to investigate our experience of laparoscopic ureterolysis (LU) and omental wrapping as a definitive surgical treatment for RPF. Patients and methods: We conducted a retrospective analysis of 17 patients who underwent LU between September 2009 and October 2018 in a single institution. Mode of presentation, investigation and interventions were reviewed. Outcome measures were stent or nephrostomy-free rates, post-ureterolysis change in estimated glomerular filtration rate (eGFR), operative time, estimated blood loss, length of hospital stay, complications and need for additional procedures. MAG3 renography was performed to assess ureteral patency. Results: Among 17 patients, a total of 23 LU procedures were performed in 20 operative sessions. Median (IQR) length of hospital stay was 4 (2–6) days. Median length of follow-up was 23.5 months (range 4–92 months), where 14 patients completed at least 15 months of follow-up. All patients were either stent ( n=9) or nephrostomy ( n=8) dependent before ureterolysis. Some 82.4% patients ( n=14) remain stent/nephrostomy free after LU. Renal function remains stable after ureterolysis with a median (IQR) change in eGFR at latest follow-up of: +7.5 (−8 to +23), ( P=0.74). Conclusions: LU is safe and effective at halting decline in renal dysfunction secondary to RPF. It has reliably avoided internal or external ureteric drainage in most patients. Consideration should be given to early referral to a specialised centre for ureterolysis in the context of multi-disciplinary management of benign RPF, to preservation of renal function and to render patients stent or nephrostomy free. Level of Evidence: 4 (case series).
The BC ADPKD Network: A Comprehensive Provincial Approach to Support Specialized and Locally Delivered Multidisciplinary ADPKD Care
Authors: Bevilacqua M. , Gradin S. , Williams J. , Romann A. , Lo C. , Djurdjev O. , Levin A. 
Published: July 2021

Purpose: With evolving evidence around the progression, assessment, and management of autosomal dominant polycystic kidney disease (ADPKD), care of the disease has become increasingly complex. Needs assessments in British Columbia (BC) described variability in knowledge and comfort with incorporating these new aspects of ADPKD care into clinical practice. Undercapture of early-stage ADPKD patients in existing renal databases was also identified as an unmet need. Sources of Information: A multidisciplinary group of clinicians and patient partners with interest and expertise in ADPKD and/or multidisciplinary kidney care informed the project work. An existing provincial renal database was used to support the provincial ADPKD registry. Methods: A formalized, comprehensive provincial ADPKD Network was created within the existing infrastructure of multidisciplinary kidney clinics (MDCs) in BC. The Network is coordinated provincially and implemented locally. It incorporates robust data collection, education, creation, and dissemination of dedicated clinical tools; collaboration between clinics and clinicians across the province; and ongoing evaluation and continuous quality improvement. Key Findings: Over the 5 years since its inception, the BC ADPKD Network has enabled increased and earlier identification of British Columbians living with ADPKD and a shift in practice toward increased and earlier enrollment of ADPKD patients into MDCs. A host of tailored ADPKD clinical tools have been created and implemented in all MDCs across the province to support existing MDC staff in the delivery of more standardized and specialized ADPKD care. A collaborative provincial clinician network founded on Local Clinical Champions has been established to support ongoing experience sharing between clinics. An evaluation framework has been established to evaluate outcomes and enable ongoing refinement of the Network. Limitations: The provincial ADPKD registry is undergoing enhancements to enable more comprehensive capture of APDKD-specific information such as total kidney volume and genetic results, but at present, this remains a limitation. It remains to be seen whether the activities of the ADPKD Network will improve long-term clinical outcomes and care experiences of patients living with ADPKD, and a long-term sustainability assessment of this model of care will be required. Implications: The structure, tools, and coordinated and collaborative clinician network established through this comprehensive provincial ADPKD Network may be valuable in addressing the variability and gaps in existing ADPKD care while allowing patients and families across BC to receive enhanced care locally, in their usual kidney care environments.
Is Isolated Hip Strengthening or Traditional Knee-Based Strengthening More Effective in Patients With Patellofemoral Pain Syndrome? A Systematic Review With Meta-analysis
Authors: Na Yuyan , Han Changxu , Shi Yuting , Zhu Yong , Ren Yizhong , Liu Wanlin 
Published: July 2021

Background: Focus on the importance of hip muscle strength in patients with patellofemoral pain syndrome (PFPS) has recently increased. It is unknown whether patients with PFPS will benefit more from hip strengthening compared with traditional knee-based strengthening. Purpose: To compare the efficiency of isolated hip strengthening versus traditional knee-based strengthening for patients with PFPS. Study Design: Systematic review; Level of evidence, 2. Methods: We conducted a search for studies comparing isolated hip strengthening and knee-based strengthening by using the MEDLINE, Embase, and Cochrane Library electronic databases. The methodological quality of included studies was assessed using the PEDro scale. Predetermined variables from each study were extracted and analyzed. Results: A total of 5 comparative studies were included in this review; all studies were of moderate to high quality and reflected good internal and external validity. Pain (visual analog scale [VAS]) and function (Anterior Knee Pain Scale) scores improved in both the hip and knee groups after strengthening intervention, although no statistically significant differences were seen between groups in the pooled analysis. In 2 studies, VAS pain scores were reduced earlier for patients in the hip group than for those in the knee group ( P < .05). In 1 study, improvement in Western Ontario and McMaster Universities Osteoarthritis Index function scores in the hip group was statistically superior compared with those in the knee group after intervention and at 6-month follow-up ( P < .05). In 2 studies, patients in the hip group exhibited statistically greater hip abductor and extensor strength than did those in the knee group after intervention ( P < .05). Conclusion: The best-available evidence suggests that overall, isolated hip strengthening and knee strengthening were equivalent for treatment of PFPS.
Diagnosis and Management of Little League Shoulder: A Systematic Review
Authors: Bednar E. Dimitra , Kay Jeffrey , Memon Muzammil , Simunovic Nicole , Purcell Laura , Ayeni Olufemi R. 
Published: July 2021

Background: Little League shoulder (LLS) is an overuse injury characterized by throwing-related pain that commonly presents in adolescent male athletes. Investigations into the optimal duration of rest from throwing and protocols for graduated return to sports (RTS) are lacking. Purpose: To summarize the current literature with respect to the diagnosis, management, RTS, and return to throwing for LLS. Design: Systematic review; Level of evidence, 4. Methods: The databases EMBASE, MEDLINE, and PubMed were searched between inception and April 22, 2020. References of retrieved records were reviewed for potentially eligible studies. English-language studies that reported the diagnosis and/or management of LLS in children or adolescents were included. Studies of animals or cadavers, review articles, and non—peer reviewed records were excluded. Data were summarized narratively using descriptive statistics. Results: Overall, 23 studies (21 level 4 studies, 2 level 3 studies) met the criteria for a total of 266 participants with a weighted mean age of 12.8 years (range, 7.4-17 years). Treatment recommendations evolved from prolonged rest and complete cessation of throwing to shorter periods of rest and graduated RTS. Less than half (11/23) of studies reported specific criteria to RTS; 1 case report discussed a coaching strategy to resume throwing, and 1 case report discussed a regimented throwing program. The proportion of participants returning to any sport participation was 94.0% (n = 157/167). The proportion returning to their preinjury level of sport was 92.5% (n = 123/133). Upon RTS, 18.7% (n = 35/187) of participants experienced a recurrence of symptoms. Premature closure of the epiphysis was reported in 1 participant. Conclusion: Young athletes with LLS may return to play after a period of rest, and a high proportion return to their preinjury level of sport. Further prospective studies are warranted to develop evidence-based, graduated RTS protocols and to better capture any long-term sequelae of the condition.