bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Local Control With High-dose Palliative Radiation Therapy for Local Advanced Breast Cancer of Mucinous Carcinoma With Malignant Wound.
Authors: Ishikawa Yojiro , Umezawa Rei , Yamamoto Takaya , Takahashi Noriyoshi , Takeda Kazuya , Suzuki Yu , Jingu Keiichi 
Published: November 2021

Abstract
Background: Patients with breast cancer who refuse standard treatment often suffer from malignant wounds due to the growth of local tumors. However, treatment strategies for patients with unresectable locally advanced breast cancer who have refused standard treatment have been unclear.Case presentation: A 44-year-old female was diagnosed with breast cancer of mucinous carcinoma in the right breast. She refused standard treatment for her breast cancer for six years. She suddenly visited the emergency department because of acute bleeding from the right breast cancer with malignant wounds. Macroscopically, the tumor in the right breast measured over 20 cm in diameter. The tumor was exudative, exhibited ulceration and slight bleeding, and gave off an odor. Imaging findings showed multiple lymph node and bone metastases, and the final diagnosis was breast cancer of stage IV (cT4bN1M1). Although the surgeon recommended chemotherapy for the breast cancer, the patient refused to receive chemotherapy or other therapy due to concerns about complications during treatment. Considering the symptoms of advanced breast cancer with malignant wounds, she finally agreed to receive radiation therapy (RT). We performed RT of 70 Gy in 35 fractions over a period of 7 weeks. The tumor-associated symptoms were disappeared after RT. At three months after RT, the tumor had almost disappeared. We administered luteinizing hormone-releasing hormone agonists after RT. At two years after RT, she died due to multiple liver metastases and appearance of ascites; however, there was no disease progression in the right breast.Conclusions: High-dose RT for local advanced breast cancer of MC with malignant wounds is therefore considered to be an effective therapeutic option.
A Computational Model of Melt Pool Morphology for Selective Laser Melting Process
Authors: Guo Kai , Qiao Lihong , Huang Zhicheng , Anwer Nabil , Cao Yuda 
Published: November 2021

Abstract
Selective laser melting (SLM) is a promising metal additive manufacturing technology, which holds widespread applications in numerous fields. Unfortunately, it is arduous to predict the real SLM part geometry, which impedes its further development. While the morphology of melt pool, influenced and determined by process parameters, poses a crucial influence on the overall part geometry. Nonetheless, the association between process parameters and melt pool morphology is still unclear. Hence it is indispensable to explore relevant solution to address this issue. For this purpose, this paper proposes a new model to directly establish the mathematical relationship between process parameters and melt pool structure for SLM process. In this model, the status of melt pool is first qualitatively analyzed via the defined synthetic process index, and three types of melting states are differentiated including low melting, intermediate melting and high melting, which could cover different melt pool modes. Then, the computational model involving more physical mechanisms integrating mass conversion, heat exchange and temperature field is constructed. Melt pool critical geometries including the height, width, depth and length could be computed through the model. In order to validate the correctness of the proposed model, published experimental observations and existing models are compared. Calculation results from the proposed model show high consistency with the experimental samples and better accuracy than existing empirical models. Its applicability in melt pool classification and prediction is also verified, laying foundation for geometric simulation of SLM object which is successively shaped melt-pool by melt-pool.
Design and Manufacturing of Low Relative Humidity Chamber for Laser Processing of Lithium Metal
Authors: Park Dongkyu , Lee Dongkyoung 
Published: November 2021

Abstract
In order to overcome the energy density limitations of lithium-ion batteries consisting of graphite anodes, studies on lithium metal batteries (LMBs) have been actively conducted. However, most LMBs related studies focus on suppressing the growth of unpredictable dendrites. Research for production processes has been rarely conducted. In the paper, laser processing is introduced to improve the drawback of conventional processing for Li metal. Moreover, a low humidity maintenance chamber is manufactured to prevent oxidation of Li metal during laser processing because Li metal easily reacts with moisture. The chamber has a closed space that does not allow outside air to enter, and a glass that allows the laser beam to pass through is installed at the upper part. In addition, silica gel is installed to maintain low relative humidity. The dew point inside the chamber drops to -17.4 ℃ in 1 hour. This result implies that the chamber can prevent Li metal oxidation. Next, we analyze the effect of transparent plate glass on laser beam with Gaussian distribution. Finally, it is confirmed through experiments that lithium metal is not contaminated by moisture during laser processing using a manufactured chamber.
Suitability of groundwater from the Kherzet Youcef lead-zinc deposit (North-eastern Algeria) for irrigation and drinking water supply
Authors: Souhila Cheddad , Abdelhamid Haouchine 
Published: November 2021

Abstract
As part of the hydrogeological study of the Kherzet Youcef deposit, a drilling battery was carried out. The objective of this achievement is the satisfaction of the water needs of the city of Ain Azel (drinking water supply, irrigation and industrial water supply) and even the transfer to other municipalities suffering by the lack of water and the resumption of mining activity at the deposit of Kherzet Youcef. This water table is located in carbonate formations of Paleo-Neogene age linked to lead-zinc mineralization. Knowledge of water quality and its suitability for human consumption is an obligation. These metals have adverse health effects. We used the results of Sonarem's analyses between 1973-1979. In addition, we carried out two analyses, during two years 2015 - 2016, on five boreholes. The parameters analyzed are major elements, physical parameters and trace metal elements (Zn, Pb and Fe). The analyses were done by ICP-AES. In our work, it has been shown that waste water is suitable for use in agriculture. For this we used the electrical conductivity at 25°C and those of the sodium adsorption ratio (SAR). For drinking water supply, monitoring the change in TME (Zn, Pb and Fe) for two years has allowed us to conclude that groundwater in the groundwater table east of the Kherzet Youcef fault is generally acceptable. They are eligible by the quality standard set by Algerian regulations. However, they exceed WHO standards, especially for lead. We recommend a revision of drinking water quality standards set by Algerian regulations, rigorous monitoring of TME content variation and water treatment before distribution.
4-aminopyridine promotes accelerated skin wound healing
Authors: Mashanipalya Jagadeeshaprasad , Govindappa Prem Kumar , Nelson Amanda , Noble Mark , Elfar John 
Published: November 2021

Abstract
The discovery of ways to enhance skin healing is of great importance due to the frequency and severity of skin wounds. We discovered that 4-aminopyridine (4-AP), a potassium channel blocker, greatly enhances skin wound healing. Benefits include faster wound closure, restoration of normal-appearing skin architecture and epidermal thickness, increased vascularization and increases in K14+ keratinocytes. Hair follicle number was increased, both histologically and by analysis of K15 and K17 expression. Levels of vimentin (which marks fibroblasts) and α-smooth muscle actin (α-SMA, which marks collagen-producing myofibroblasts) increased, as did α-SMA+ cell numbers. 4-AP also increased numbers of axons and S-100+ Schwann cells, and increased expression of p75-NTR and SOX10. Treatment also increased levels of nerve growth factor, transforming growth factor-β, Substance P and PGP9.5, important modulators of wound healing. As 4-AP is already used for treatment of multiple sclerosis and other chronic neurological syndromes, it has strong potential for rapid translational development.
Survival of Microencapsulated Lactococcus Lactis Subsp. Lactis R7 Applied in Different Food Matrices
Authors: Rosolen Michele Dutra , Bordini Fernanda Weber , Luz Gabriela de Quadros da , Diaz Patrícia Silva , Conceição Fabricio Rochedo , Fiorentini Ângela Maria , Silva Wladimir Padilha da , Pieniz Simone 
Published: November 2021

Abstract
Survival of Lactococcus lactis subsp. lactis R7 microencapsulated with whey and inulin was analyzed when applied in blueberry juice, milk and cream. For 28 days, cell viability was evaluated for storage (4°C), simulated gastrointestinal tract (GIT) and thermal resistance. All matrices described high cell concentration when submitted to GIT (11.74 and 12 log CFU.mL-1), except for blueberry juice. The thermal resistance analysis proved the need for microencapsulation, regardless of the food matrix. The results indicate that L. lactis R7 microcapsules have potential for application in different matrices and in the development of new probiotic products by thermal processing.
Behavioral And Psychiatric Health Problems In Iranian Students During The COVID-19 Pandemic
Authors: Talebi Mahdi , Sany Seyedeh Belin Tavakoly , Kiani Mohammad Ali , Layeghi Darab , Ghasemi Mehri , Taheri Maryam , Taheri Ahmad Reza , peyman Nooshin 
Published: November 2021

Abstract
Background: the study of behavioral and psychiatric health problems in space and time, can help to improve health services for adolescents and children by increasing understanding of causes, development, and course of psychiatric disorders. This study aimed to examine the behavioral and psychiatric status of adolescences during the pandemic to address the effect of the pandemic and isolation on adolescent behavioral and psychiatric health.Methods: This cross-sectional study has been carried out through cluster sampling design on 322 normal students aged 12-18 attending in public high and elementary school in Esfahan, Iran. They completed study instrument that included the 110-item the Child Symptom Inventory-4 (CSI-4) and those inquiring the students’ demographic information. Results: Findings showed that 58% students met criteria for all psychiatric symptoms except of the autism and Asperger’s disorders, and 39.5% suffered from more than one comorbid categories of psychiatric disorders. The most common psychiatric disorders in boys and girls were ADHD (18.5%), ODD (15%), ADHD-C (13.5%), GAD (12.8%), ADHD: HI (11.5), and MDD (10.8%). Conclusion: Most of students suffered from more than one co-morbid category of psychiatric disorders. It is better to develop effective strategies and interventions, train students about self-protection, and establish a psychological crisis intervention team to minimize the psychological impact of the COVID-19 pandemic.
The Target E2F Family Gene PTTG1 for Prediction of Distant Relapse-Free Survival in Breast Cancer Patients Receiving Taxane and Anthracycline-Based NACT
Authors: Xu Yu-hao , Du Yao-qiang , Zheng Qing-hui , Xu Qiu-ran , Meng Xuli 
Published: November 2021

Abstract
Background: The breast cancer is the most commonly diagnosed cancer in recent years. The use of neoadjuvant chemotherapy (NACT) makes a significant contribution to chemotherapy in breast cancer. We aimed to develop the novel model as a predictor of distant relapse-free survival (DRFS) in breast cancer patients receiving taxane and anthracycline-based NACT.Methods: We collected the mRNA expression datasets of patients from GSE25055 and GSE25065 in Gene Expression Omnibus (GEO). Univariate and Multivariate Cox Regression Analyses were conducted to achieve the prognostic genes that associated with DRFS. Moreover, the E2F target genes were obtained from GSEA. We obtained the intersection genes between the prognostic genes and E2F target genes, then validated in GSE32603 dataset. And we established a nomogram model based on PTTG1 expression level and several clinical characteristics.Results: There were 95 genes confirmed to be associated with DRFS both in GSE25055 and GSE25065. And PTTG1 was validated as a gene related to DRFS and associated with E2F target hallmark using GSEA analysis and chosen as our target gene. The AUC of PTTG1 model was 0.682 indicating a relatively poor prediction performance. Then a novel nomogram was conducted, the receiver operating characteristic (AUC=0.849), C-index (0.805) and calibration plots were applied to assess the effect of this model.Conclusion: Our study found that the E2F target genes, such as the PTTG1 may serve as a potential biomarker in breast cancer, and provided superior estimation of DRFS, which can guide the clinical practice in NACT of breast cancer.
Instegating Pne In Patient Of Algophobic Chronic Low Back Pain
Authors: kulkarni Yash , Walimbe Vaibhavi , Mahajan Saurabh , Thorat Aniruddha , Chitapure Tajuddin 
Published: November 2021

Abstract
Chronic low back pain is the leading cause of disability and health care usage and is also a common condition requiring Physio therapeutic intervention. The most common symptom in musculoskeletal condition is pain. Pain which lasts for less than a 3 months is called as acute pain which last more is defined as chronic pain. Pain is a complex phenomenon involving both emotional and physical component. Current intervention and approaches are more physical component based which leads to treatment of just physical component. the emotional component usually leads to avoidance the avoidance can be because of fear of pain which is termed as algophobia Pain Neuroscience education is useful approaching treatment of emotional component of pain. pne approach includes explanation of pain using photos images videos or even verbally In this report a 65year-old female came with complaints of chronic low back pain for 6 months the p ain was present on the left side. Intervention used is pain neuroscience education to ­­chronic low back pain. The report represents the effectiveness of PNE with the conventional mode of treatment is useful in the treatment of chronic low back pain. The results demonstrated improvement in quality of life and reduced fear and catastrophization.
“Now we’ve all turned to Eating Processed Foods”: A Photovoice Study of the Food and Nutrition Security Implications of ‘Galamsey’ in Ghana
Authors: Nyantakyi-Frimpong Hanson , Christian Aaron Kobina , Ganle John , Aryeetey Richmond 
Published: November 2021

Abstract
Background: Small-scale mining, referred to as galamsey in Ghana, is an important source of income for many rural populations. Although concerns have been raised in the media about the significant threats galamsey poses to the environment, and human health and livelihoods, there is a representational paucity of evidence regarding its links with local food systems, particularly from the perspective of affected mining communities. The current study explored community perceptions and experiences of galamsey and its perceived effects on food security and livelihoods in the East Akyem Municipality in the Eastern region of Ghana. Methods: Primary data was collected in the East Akim District of Ghana, using photography, interviews based on the photographs, and a photo exhibition, all conducted . Thirty-six male and female adults were purposively selected with the help of a community focal person and advertisements in the study community. Respondents participants in a one-day photography training and thereafter, deployed to take at least fifteen photos that portray the effect of galamsey on food security and health. Subsequently, each participant was asked to selected five of the photographs and to explain the image and why they captured that in the photo. A photo exhibition was held to facilitate community conversation and perspectives on the effects of galamsey on food and nutrition security. Results: Galamsey has resulted in degradation of, otherwise, fertile agricultural land, and contamination of freshwater sources. As a consequence, there is reduced cultivable land, reduced crop production, shortage of essential staple foods, increase in food price, and increased consumption of ultra-processed foods. There is also perception of increased exposure to heavy metals like mercury in locally-produced food. Conclusions: Given the adverse health consequences of both food and nutrition insecurity, and increased consumption of processed foods, it is important that public and policy discussions to minimize the effects of galamsey in Ghana should include considerations about food and nutrition insecurity in mining communities.
Multi-objective Tubular Hydroforming Process Parametric Optimization using TOPSIS and PSI techniques
Authors: Reddy Pathapalli Venkateshwar , Reddy B. Veerabhadra 
Published: November 2021

Abstract
Tube Hydroforming (THF) process is widely used in the aerospace and automotive industries. The success of forming tubular components using the THF process generally depends on many influencing parameters such as geometry, coefficient of friction, loading pathways, material formability, etc. The objective of this study was to determine the effect of the corner radius, coefficient of friction and heat treatment temperature on the bulging of the tubular component using finite element simulations. To address the complexity of parameter selection correctly with different alternatives, the multi-criteria decision-making methods (MCDM) applied in the present work. Two decision models, namely Technique for Order Performance by Similarity to Ideal Solution (TOPSIS) and Performance Selection Index (PSI) methods with entropy weighting criteria were applied for obtaining the best combination of parameters to get a sound quality product. Finally, the proposed ranking was validated by conducting experimental trials and the error was observed to be in limits in comparison with the simulated data. ANOVA was also performed to distinguish the significant parameters and their contribution to the responses. Both the MCDM methods suggested the same favorable and unfavorable alternatives.
Biosorption of Chromium by Agricultural Waste, Anacardium Occidentale Testa Powder: Characterization, Kinetic, Isotherm and Thermodynamic Studies
Authors: GUNDLAPALLI SWARNALATHA , Gunturu Chandrakala , Naidu Sureddy V 
Published: November 2021

Abstract
The study on low-cost biosorbent such as Anacardium occidentale testapowder was used to remove chromium from aqueous solutions. Based on R 2 values, the Langmuir (R 2 = 0.9927) model fitted the equilibrium biosorption data best, confirming monolayer adsorption of chromium on to the biosorbent surface. The biosorption of chromium was best described by pseudo-second order (R 2 =0.9902) kinetics since at all concentrations, the R 2 values were higher than the corresponding pseudo-first order (R 2 = 0.9278) values. Based on thermodynamic parameters the biosorption of chromium by Anacardium occidentale testa powder was found to be spontaneous, endothermic and feasible under optimized conditions.
Survival Analysis of Women Exposed to Humidifier Disinfectants during the Perinatal Period: A Nested Case-Control Study
Authors: Cho Jun Sung , Choi Seoheui 
Published: November 2021

Abstract
Background
Because humidifier disinfectants (HDs) have been prohibited by the government because of their potential serious effects on human body, several studies on the relationship between HD and lung diseases have been separately performed on children and adults; however, to our knowledge, no studies have investigated the effects of HD exposure on pregnant women and their fetuses. Therefore, the present study aimed to investigate the effects of HD exposure on the fetuses of women who were exposed to HDs during pregnancy.
Methods
We collected data from the Korea Environment Industry & Technology Institute (KEITI) to investigate the effects of HD exposure on the fetus during pregnancy. Among the applicants, mothers with HD exposure during pregnancy were recruited to determine the damage from HD. Others were included by self-referral or by their guardians. From 2017 to 2020, there were 56 cases. All had been exposed to HDs from 1994 to 2006. Seven cases were excluded because HD exposure did not coincide with pregnancy. We determined the effects of HD exposure on maternal-fetal survival and classified the duration of exposure as it related to the various stages of pregnancy, including prepregnancy, trimester of pregnancy, and seasonal variation. A subgroup analysis based on maternal-fetal survival was performed as a nested case-control study.
Results
Of the 49 mothers, 22 (44.9%) survived, and 27 (55.1%) died. In the group of survivors, the total duration of exposure (P = 0.004), the duration of exposure until symptom onset (P = 0.023), the duration of exposure before delivery (P = 0.023), and duration of exposure before pregnancy (P = 0.010) were shorter than those in the group who died. Of the mothers who survived, 50% were exposed before pregnancy, and 66.7% of the mothers who died were exposed before delivery.
Conclusions
A shorter period of HD exposure was associated with a higher likelihood of maternal survival. Also, a shorter time from childbirth to symptom onset was associated with a higher likelihood of maternal-fetal survival.
Early Ambulation After Transfemoral Diagnostic Cerebral Angiography: A Pilot Study
Authors: Aljuboori Zaid , Eaton Jessica , Carroll Kate , Levitt Michael , Kim Louis 
Published: November 2021

Abstract
BackgroundA significant proportion of transfemoral cerebral angiography complications are related to the access site, with no clear consensus concerning the optimal closure technique. In this study, we examined the usefulness of a new closure protocol for transfemoral diagnostic cerebral angiography.MethodsWe performed a retrospective review of patients who underwent transfemoral (4Fr sheath) diagnostic cerebral angiography procedures at our institution. We included patients >18 years old who underwent the new closure protocol to achieve hemostasis at the access site. The new protocol entailed the use of nonocclusive manual compression for 15 minutes followed by 2 hours of bed rest, with additional 10-15 minutes of compression for new hematoma. We collected and analyzed the patients’ demographics, use of antiplatelet and anticoagulation medications, sheath size, and others.ResultsThe study cohort comprised 119 patients with a mean age was 54 years with (88%) females. Forty-one patients (34%) were on antiplatelet medications, with 12 (10%) on dual antiplatelet therapy (DAPT). Four patients (3%) (two on DAPT, one on Aspirin alone, and one was not on any antiplatelet medication) had access site hematoma that required additional compression. Subgroup analysis showed that within the DAPT, Aspirin alone, and no antiplatelet medications groups, (17%), (3%), and (1%) of patients developed access site hematoma, respectively.ConclusionThis pilot study demonstrates that our closure protocol for transfemoral angiograms is safe and effective. There was a trend toward higher access-site complications in patients on DAPT. Further studies are required to expand on and validate our results.