bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular Endothelial Growth Factor Is Essential for Hyperglycemia-Induced Structural and Functional Alterations of the Peritoneal Membrane
Authors: VRIESE AN S. DE , TILTON RONALD G. , STEPHAN CLIFFORD C. , LAMEIRE NORBERT H. 
Published: April 2021

Abstract.
Long-term peritoneal dialysis is associated with the development of functional and structural alterations of the peritoneal membrane. Long-term exposure to the high glucose concentrations in conventional peritoneal dialysate has been implicated in the pathogenesis of peritoneal hyperpermeability and neoangiogenesis. Vascular endothelial growth factor (VEGF) is an endothelial-specific growth factor that potently stimulates microvascular permeability and proliferation. High glucose exposure upregulates VEGF expression in various cell types and tissues. This study investigated whether VEGF plays a pathogenetic role in hyperglycemia-induced microvascular dysfunction in the peritoneal membrane. The peritoneal microcirculation of streptozotocin-induced diabetic rats and age-matched controls was studied in vivo with a combination of functional and morphologic techniques. The diabetic microcirculation was characterized by an elevated transport of small solutes, indicating the presence of an increased effective vascular surface area. The leakage of FITC-albumin was more rapid in diabetic vessels, suggesting hyperpermeability for macromolecules. Structurally, an increased vascular density with focal areas of irregular capillary budding was found in the diabetic peritoneum. The hyperglycemia-induced structural and functional microvascular alterations were prevented by long-term treatment with neutralizing anti-VEGF monoclonal antibodies, whereas treatment with isotype-matched control antibodies had no effect. VEGF blockade did not influence microvascular density or macromolecular leakage in control rats, demonstrating specificity for the hyperglycemia-induced alterations. The present results thus support an causative link among high glucose exposure, upregulation of VEGF, and peritoneal microvascular dysfunction.
La traducción al asturianu como ferramienta d’espardimientu de la llingua nel Surdimientu. El casu del Teatru
Authors: Fernández Fernández David 
Published: April 2021

La traducción d’obres lliteraries al asturianu yera un llabor conocíu enantes del Surdimientu, pero sedrá cola nacencia d’esti movimientu cultural y lliterariu a partir de mediaos de los años 70 del s. XX cuando esta actividá espoxigue hasta llegar a un bon altor. Dende esta dómina dirán conociéndose n’Asturies delles tornes dende llingües como l’inglés, el francés, l’italianu… que tienen como oxetivu facer llegar grandes títulos de la lliteratura universal a los llectores que teníen como llingua materna l’asturianu. Y atoparemos tamién traducciones de calter non lliterariu.
Nesti artículu va afondase nel casu del teatru, ún de los xéneros con menos traducciones al asturianu que cuntaba amás con un problema amestáu, la solombra del teatru costumista –popular por demás ente’l públicu asturiano– qu’enzancaba la medría del nuevu teatru. Centrándonos nos datos recoyíos de les publicaciones en volume de traducciones d’obres de teatru al asturianu y los testos teatrales traducíos nes revistes Lletres Asturianes y Lletres lliterariu asoleyaes pola Academia de la Llingua Asturiana, ufiertaráse un panorama de la traducción teatral dende’l Surdimientu, afondando nes llingües de les que se traduz, los autores que se traducen y los traductores que faen esi trabayu.
Armando Lázaro Ros (1886-1962): una reconstrucción bio-bibliográfica = Armando Lázaro Ros (1886-1962): a bio-biographical reconstruction
Authors: Guzmán Mora Jesús 
Published: April 2021

Amando Lázaro Ros (1886-1962) trabajó como traductor y editor para la editorial Aguilar durante las dos primeras décadas del franquismo. Aunque este aspecto ha suscitado el interés de los estudios académicos, poco más se conoce de él. Comprometido intelectualmente con la izquierda durante la ii República y la Guerra Civil, estuvo encarcelado más de cinco años tras el conflicto. Además, escribió varias obras de creación literaria que han caído en el olvido. En este artículo realizamos un estudio bio-bibliográfico para reconstruir la vida y la obra del autor. Para ello nos servimos de las fuentes primarias, secundarias y, especialmente, de los documentos custodiados en diferentes archivos.Amando Lázaro Ros (1886-1962) worked as a translator and editor for Aguilar publishing house during the first two decades of the Francoism. Although this subject has been studied, we know little about him. Committed to lelf-wing political throughout the Second Spanish Republic and the Spanish Civil War, he was imprisoned five years after the conflict. Besides, he wrote some novels that have fallen intooblivion. This paper attempts to be a bio-bibliographic study of the author’s life and the literary work. To this end, we analyze the primary and secondary sources and, especially, the documents guarded in different archives.
Juan Benet y el pensamiento místico: más allá del fatalismo = Juan Benet and mystical thought: beyond fatalism
Authors: Machín Lucas Jorge 
Published: April 2021

El presente artículo aborda la influencia mística en la obra literaria de Juan Benet. Es un aspecto crucial para entender el deseo de los protagonistas de sus novelas de volver al origen y de recomenzar la historia frente a la ruindad de un mundo en guerra y en destrucción. Es un anhelo, por supuesto, frustrado por la cruel realidad que les rodea de guerra, de ruinas y de destrucción física y moral. Esto se puede apreciar sobre todo en novelas tales como Volverás a Región, Una meditación, Un viaje de invierno o Saúlante Samuel y en su libro de ensayos El ángel del señor abandona a Tobías.This article is about mystical influence in the literary works of Juan Benet. This is a crucial aspect so as to understand the desire of the protagonists of his novels to return to the origin and to start over history against the evilness of a world in war and in destruction. Of course, it is a longing which has been frustrated by the cruel reality which surrounds them, with war, ruins, and physical and moral destruction. All this is obvious in such novels as Return to Region, A Meditation, A Winter Trip and Saul Facing Samueland in his book of essays The Angel of the Lord Abandons Tobit.
JUAN CARLOS ABRIL, El habitante de su palabra. La poesía de José Manuel Caballero Bonald (1952-2015), Madrid, Visor Libros, 2018, 459 pp.
Authors: Mármol Ávila Pedro 
Published: April 2021

Reseña de JUAN CARLOS ABRIL, El habitante de su palabra. La poesía de José ManuelCaballero Bonald (1952-2015), Madrid, Visor Libros, 2018, 459 pp.
Salas Barbadillo y la parodia cortesana de la "Vida del malvado varón a quien el vulgo dio el nombre postizo de panza dichosa" = Salas Barbadillo and the courtly parody of the "Vida del malvado varón a quien el vulgo dio el nombre postizo de panza dichosa"
Authors: Coppola Leonardo 
Published: April 2021

A través del análisis de la primera narración del «malvado varón» de El curioso y sabio Alejandro, juez y fiscal de vidas ajenas, de Alonso Jerónimo de Salas Barbadillo, se intentará desvelar la sátira política que se esconde detrás del primer retrato que avanza la apariencia de una Corte farsante. La materia satírico-cortesana representada en la voracidad del glotón «Panza dichosa», marcado por su final desnutrición, representaría, asimismo, la imagen decaída de una Corte infernal en la que Salas parece dirigirse directamente al monarca. Through the analysis of the first narration of the «malvado varón» in El curioso y sabio Alejandro, juez y fiscal de vidas ajenas, by Alonso Jerónimo de Salas Barbadillo, an attempt will be made to reveal the political satire that hides behind the first portrait that advances the appearance of a deceptive Court. The satirical-courteous matter represented in the voracity of the gluttonous «Panza dichosa», marked by its final malnutrition, would also represent the decayed image of a hellish Court in which Salas seems to address the monarch directly.
Rodrigo Osorio sobre dos coplas que se hallaron al señor don Jorge Manrique en el seno cuando lo mataron. Un nuevo testimonio manriqueño = Rodrigo Osorio sobre dos coplas que se hallaron al señor don Jorge Manrique en el seno cuando lo mataron. A new testimony of Jorge Manrque
Authors: Beltrán Vicenç 
Published: April 2021

Uno de los testimonios conocidos de las dos coplas póstumas de Jorge Manrique es el pliego suelto recientemente descubierto que se atribuye a Rodrigo Osorio, con seguridad el antígrafo de donde estas pasaron al Cancionero general de 1535. El estudio de este pliego permite acercarnos a una identificación de su autor y a los ambientes en que fue escrito y a la vez se convierte en un testimonio privilegiado para conocer el impacto de Manrique sobre la producción poética de principios del siglo XV. One of the known witnesses of the two posthumous stanzas of the Coplas by Jorge Manrique is a chap-book recently discovered, attributed to Rodrigo Osorio, in all probability the antigraph from which they were taken for the 1535 edition of the Cancionero general. By studying this chap-book we discover the identity of its author and the circumstances in which it was written. At the same time, it becomes a preferred witness to understand the influence that Manrique had on early sixteenth-century poetry.
Study of knowledge, attitude, practice of rational use of medicines among interns at Mc Gann teaching district hospital, Shivamogga- a descriptive cross-sectional study
Authors: Hanumaiah Vedavathi , Revankar Shreenivas , P. Abhishek C. 
Published: April 2021

Background: Rational use of medicines requires that the patients receive medication appropriate to their clinical needs, in doses that meet their own individual requirements for an adequate period of lime, and at the lowest cost to them and to their community. Objective of the study were like descriptive cross- sectional study was conducted to determine and identify the level of knowledge, attitude and practice regarding rational use of medicines among the interns.Methods: A validated structured questionnaire containing 19 questions regarding rational use of medicines in knowledge, attitude and practice (KAP) format was distributed in hand among 109 interns affiliated to this institution. Descriptive statistics were used to illustrate the results in the form of number and percentage.Results: Out of 109 interns, 102 completed the questionnaire and were included in the final analysis. Majority of interns who participated in study were aware of the concept of rational use of medicine but the knowledge related to EML (essential medicines list), P drugs, schedule H drugs and number of FDCs (fixed dose combination) in EML was limited.Conclusions: As interns are future prescribers, they need to be aware of all the aspects of rational use of medicine and there is need to emphasise on learning module and training programs to ensure the interns have knowledge of rational use of medicines.
Short term outcome of primary un-cemented total hip arthroplasty in osteonecrosis of femoral head
Authors: Rather Mohmad Nawaz , Mir Wajahat Ahmad , Khan Shahid Shabir , Mir Naseer Ahmad , Ali Nadeem 
Published: April 2021

<p class="abstract"><strong>Background:</strong> Osteonecrosis of femoral head (ONFH) is characterised by cell death in the subchondral bone caused by abnormalities of blood flow to the femoral head. About 5% to 13% of arthroplasties are performed yearly for ONFH in United States. Ficat and Arlet classification is the commonest system used for grading of ONFH. Advanced stages 3 and 4 are best managed with total hip arthroplasty (THA). THA restores hip range of movement and allows early ambulation in ONFH.</p><p class="abstract"><strong>Methods:</strong> After seeking approval from local institutional ethical committee 25 patients with stage 3 and stage 4 ONFH (Ficat and Arlet) were admitted from OPD of SKIMS MC and Hospital Bemina, Srinagar. The study was conducted from February 2018 to February 2020 in department of Orthopaedics SKIMS MC and Hospital Bemina, Srinagar. 25 patients with mean age of 50.64 years comprising of 13 females and 12 males with unilateral osteonecrosis of femoral head with collapsed head underwent uncemented total hip arthroplasty and were followed up to a minimum of 1 year post-operatively.<strong></strong></p><p class="abstract"><strong>Results:</strong> Outcome was evaluated by comparing pre-operative and post-operative Harris hip scores. The average Harris hip scores improved from 65.87 in the pre-operative group to 96.54 at 1-year follow-up post-operatively. Marked improvement was noted in pain scores. No revisions were performed during the study. One patient developed superficial surgical site infection which healed with supervised dressings and oral antibiotics.</p><p class="abstract"><strong>Conclusions:</strong> Uncemented THA has excellent short-term outcomes in advanced stages of ONFH. It provides mobile hip joint and pain free ambulation shortly after surgery.</p>
Manufacturing a Biomimetic Biorecator in Cardiac Tissue Engineering
Authors: Shams Zahra , Akbari Babak , Rajabi Sarah , Aghdami Nasser 
Published: April 2021

Introduction: The direct approach of cardiac tissue engineering is to mimic the natural tissue of heart, considering the significant role of scaffolding and mechanical simulation.
Methods: To achieve this purpose, a composite Polycaprolactone (PCL)/Gelatin electrospun scaffold with a ratio of 70:30 and with the most similarities to the cardiac extracellular matrix was fabricated with aligned nanofibers. The scaffold was evaluated using scanning electron microscopy (SEM), mechanical strength analysis, and contact angle test. To simulate the cardiac contraction, a developed Mechanical Loading Device (Bioreactor) was designed to apply a mechanical load with a specific frequency and tensile rate values in the direction of aligned nanofibers due to simulating natural cardiac tissue.
Results: Based on our results from the contact angle and mechanical strength tests, we concluded that our designed scaffold has appropriate adhesion and strength to use as cardiac scaffold and is suitable for imposing the frequency of 1Hz and 10% strain. The Bioreactor also worked properly in producing the required frequency, tensile rate and temperature.
Conclusion: Since an essential difference between cardiomyocytes and other cells is their contraction, manufacturing a biomimetic bioreactor to simulate the normal cardiac contraction of cardiomyocytes and their required temperature to be survived in-vitro could be a promising approach in cardiac tissue engineering.
Baseline Model for Electricity Generation Expansion Planning for The Philippines: A Leap Model Application
Authors: Nobleza Bryan Joseph C. , Arriola Emmanuel R. , Pedrasa Michael Angelo A. 
Published: April 2021

Philippines is one of the fastest-growing economies and most populated countries globally, greatly affecting its energy demand. The increase in demand leads to an increase in the electricity generation sector's capacity to maintain the supply-demand balance. Thus, this may lead to power shortage, high generation costs, and increased greenhouse gas emissions without proper energy planning. This study aims to create a Long-Range Energy Alternatives Planning System (LEAP)-based Baseline Model for the Philippines' generation expansion planning. The model will serve as a tool for the government and energy planners to develop a long-term generation expansion planning model. The model simulates the technological, economic and environmental aspect of the existing Philippine power generation system that can be used as a baseline for developing a Business-As-Usual Scenario and Alternative Scenario models to assess different energy policy pathways. The developed LEAP model following an independent multi-regional and national scale structure that is based on the Philippine grid and off-grid based regions showed an accurate result with the actual data. The model was able to replicate the actual power generation through the set-up of basic parameters. Development of Philippine LEAP structure; and the establishment of the demand, transformation, and resources module’s structure are based on the set of data input parameters. The baseline model developed can be used for continuing studies such as impact evaluation of energy policy for long term power generation expansion planning.
Analysis of the Information Transfer Rate-ITR in Linear and Non-linear Feature Extraction Methods for SSVEP Signals
Authors: De la Cruz Danni , Alfonso Wilfredo , Caicedo Eduardo 
Published: April 2021

The most popular paradigm in BCIs is the steady-state visually evoked potential (SSVEP) due to their advantages, such as the high information transfer rate (ITR), the time spent on users in the training phase, and the capacity to discriminate each stimulus. One of the most influential factors in the ITR evaluation is the feature extraction methods since these can increase the accuracy. Here, we compare nine methods for the extraction of features from SSVEP signals to identify those with better performance, according to the time window (TW), its technology (equipment and number of nodes), and the value of ITR. The study identifies two groups: the first one is characterized by presenting variations of correlated component analysis (CCA), which is highly used to increase the ITR due to its efficiency in classification and its capacity of response to reduction (TW), such as MsetCCA, IT-CCA, FBCCA; the second one are the representation special based methods that consider the non-linear nature of the electroencephalogram (EEG) signal such as TRCA, CORRCA, EMD, and VMD. The results show a considerable difference between these groups. The maximum ITR value for FBCCA was 117.75 [bits/min] in a TW of 1.25s, while the VMD method achieved 3120 [bits/min] in a TW of 1s, respectively. The comparison covers signals between 0.55 and 8 seconds, taking into account visual strain, the experimental environment, and other artifacts.
O SETOR INDUSTRIAL E SEUS EFEITOS NO MERCADO DE TRABALHO FORMAL: UMA ANÁLISE PARA O TRIÂNGULO CRAJUBAR-CE (2008-2018)
Authors: Nascimento Carlos Eduardo Pereira do 
Published: April 2021

Este trabalho objetiva analisar o mercado de trabalho formal sob a ótica do setor industrial no CRAJUBAR para os anos 2008 e 2018, evidenciando o panorama da economia da região via indústria, bem como as repercussões sobre a institucionalização da RM Cariri, em 2009. A metodologia utilizada é de caráter exploratório. O meio técnico utilizado foi o estatístico. Tem-se como área de pesquisa o triângulo CRAJUBAR, formado pelos municípios Crato, Juazeiro do Norte e Barbalha, tendo como foco de análise o setor industrial formal. Faz-se uso de microdados, referentes aos anos de 2008 e 2018, provenientes do banco de dados da RAIS/MTE e do IBGE. Conclui-se que o perfil de mão de obra do setor industrial apresenta melhor nível educacional, porém em postos de trabalho que não condizem com sua realidade escolar, com baixa participação das mulheres, as quais ainda encontram desafios na tentativa de igualar as remunerações com a classe masculina. .
Mulheres e resistência em O país sob minha pele, de Gioconda Belli
Authors: Resende Joelma De Araújo Silva , Dos Santos Raimunda Maria , Lopes Sebastião Alves Texeira 
Published: April 2021

O objetivo dessa pesquisa é investigar a participação da mulher no movimento revolucionário na Nicarágua, a partir do livro de memórias O país sob minha pele, de Gioconda Belli, escritora nicaraguense que participou do movimento sandinista, que derrubou a ditadura de Somoza. Para isso, foi feita uma análise da relação entre mulher e nação, dando-se ênfase à participação feminina na luta contra a ditadura. Para tanto, cita-se Zinani (2010), que aborda os escritos femininos sobre ditadura, Mattoso (2010), que retrata a identidade nacional, e Walby (2000), que analisa a relação entre mulher e nação. Percebe-se que a mulher tenta conquistar um espaço na vida social, lutando pelo que considera mais justo para seu país, sendo assim, agente de transformação social. Percebe-se também que, apesar de não reconhecida pela historiografia oficial, a mulher participa do projeto de construção nacional na Nicarágua, como demonstrado por Gioconda Belli.
Alcohol and Condomless Insertive Anal Intercourse Among Black/Latino Sexual-Minority Male Non-PrEP Users
Authors: Washington Thomas Alex , Brocato Jo , Applewhite Sheldon , Dyson Yarneccia D. , Ramos Angel 
Published: April 2021

ObjectiveThis study examined factors associated with alcohol use and condomlessinsertive anal sex among a sample of BLMSM (N = 188), self-identified as HIV- negative, ages 18–40. The influence of alcohol use on sexual positioning during condomless anal intercourse among Black and Latino men who have sex with men (BLMSM) warrants research attention because of the pervasive misinformation regarding the risk of HIV transmission and the disproportionate impact of the HIV epidemic for this population.MethodsSelf-report survey questionnaires were administered in real time at bars/clubs; public organized events; local colleges/universities; social media advertisements; private men's groups; and organized events in Los Angeles County.ResultsLogistic regression predicted those reporting risky sex when using alcohol were seven times more likely to report condomless insertive anal sex.ConclusionClear messaging about alcohol moderation, dispelling the myths about strategic positioning, and pre-exposure prophylaxis (PrEP) use among HIV negative BLMSM could potentially reduce HIV acquisition/transmission.
RISK FACTORS IN PULMONARY TUBERCULOSIS TREATMENT FAILURE
Authors: Nugrahaeni Dyan Kunthi , Rosmalaningrum Lala 
Published: April 2021

Pulmonary tuberculosis (TB) is a global health problem and has become the leading cause of death. Tuberculosis eradication is inhibited due to the tendency of patients to not complete the TB treatment. The purpose of this study was to determine the relationship between knowledge, nutritional status, oral medication adherence, and family support as risk factors for pulmonary tuberculosis treatment failure. The design of this study is that of case-control, and this study involved samples of pulmonary TB patients who were declared not cured after treatment (14 people), and control samples of pulmonary TB patients who were declared cured (28 people). The data were obtained through measurements of nutritional status and interviews, while treatment failure was based on data from the TB 01 form. Data was analysed using univariable and bivariable analyses, and the magnitude of risk factors was based on the odds ratio (OR) and 95% confidence interval (CI). The results showed that the factors associated with failure of pulmonary TB treatment are knowledge (p = 0.022; OR = 6.6; 95% CI = 1.48 - 29.36), nutritional status (p = 0.005; OR = 9.16; 95% CI = 2.11 - 39.85), and medication adherence (p = 0.003; OR =11.0; 95% CI = 2.37 - 54.14), whereas the unrelated factor is family support (p = 0.47). It is recommended to provide counselling, nutritional guidance, medication assistance, and family support to patients during the treatment period for pulmonary tuberculosis. Keywords: treatment failure, knowledge, nutritional status, compliance