bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatoprotective Activity of Ethanol Extract of Figs Leaves (Ficus carica L.) with SGOT & SGPT Parameters in Sprague Dawley Female Rats Induced by Paracetamol
Authors: Kurniawan Muhammad Fariez , Wardany Herdita Nugraheny Kusuma 
Published: October 2021

Background: Long-term usage of paracetamol damages liver cells characterized by the increasing levels of Serum Glutamic Pyruvic Transaminase (SGPT) and Serum Glutamic Oxaloacetic Transaminase (SGOT). Figs (Ficus carica L.) leaves contain high flavonoid compounds that able to act as hepatoprotector agents which inhibited the process of liver damage. Objectives: This study aims to determine the dose characteristics and hepatoprotective activity of figs (Ficus carica L.) leaves extract. Material and Methods: The hepatoprotective activity of figs extract (Ficus carica L.) was determined by measuring SGPT & SGOT levels in rat blood. 42 rats were prepared, divided into 7 groups: normal control group, negative control given paracetamol with a dose 40 mg/200 g BW, positive control given hepamax®, base control given Na CMC, and 3 test dose groups given figs leaves extract with a dose of 40 mg/200 g BW, 80 mg BW/200 g BW and 160 mg/200 g BW. The treatment was carried out for 14 consecutive days. Paracetamol was given for 14 days, while positive control, 3 test dose groups and base control were given on day 7 to day 14. Rats blood samples were taken through the orbital sinuses on day 1, day 5, day 10 and day 14 after treatment began. SGPT & SGOT levels were determined using spectrophotometry with analytical methods using specific SGPT & SGOT reagent kits. Results: The results showed that the leaves extract of figs (Ficus carica L.) proved to be able to reduce the levels of SGPT & SGOT with the most potent dosage was 40 mg/200 g BW. However, the reduction of SGPT & SGOT levels were not significantly different from other treatments. Conclusions: Figs (Ficus carica L.) leaves extract showed activity as a hepatoprotective agent, based on the reduction of SGPT & SGOT levels in rat after 14 days of treatment.
The relationships between obstructive sleep apnea and psychiatric disorders: a narrative review
Authors: Karakuła Kaja Hanna , Ryczkowski Aleksander , Sitarz Elżbieta , Januszewski Jacek , Juchnowicz Dariusz 
Published: October 2021

AbstractIntroduction:Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder. Its prevalence tends to increase worldwide. Untreated sleep apnea is associated with a higher risk of metabolic diseases, cardiovascular diseases, stroke, road accidents, and death, but also it is suggested that it increases the risk of mental disorders.Method:The literature review was based on a search of articles on Medline, Pubmed, and Google Scholar from 2003 to 2021 using the keywords: obstructive sleep apnea; mental disorders; cognitive functions; affective disorders; depression; bipolar disorder; schizophrenia; psychotic disorders. The analysis included original studies, meta-analysis, and review articles.Discussion:The result obtained from researches published so far does not allow for drawing unequivocal conclusions. There is a lot of bias present in study protocols and inclusion/exclusion criteria. Nonetheless, it seems that some disorders have a better proven correlation with OSA. Cognitive impairment, depression, and anxiety disorders are linked to OSA not only in terms of the overlapping of symptoms but also of a causal relationship. Psychotic disorders and bipolar disorders connections with OSA are confirmed, but they are not yet well understood. All correlations are found to be possibly bidirectional.Conclusion:1. Multiple lines of evidence increasingly point towards a bidirectional connection between OSA and mental disorders, and the cause and effect relationship between these two groups of disorders requires further research.2. Due to reports of an increased risk of OSA with antipsychotic drugs, caution should be exercised when initiating therapy with this type of drug in patients with known risk factors for it.3. Screening for OSA in psychiatric patients should be introduced as OSA can increase cognitive impairment, affective, and psychotic symptoms.
Current practice of physical therapists in outpatient stroke rehabilitation: a cross-sectional survey in Baden-Württemberg and Thuringia / Arbeitsweise von Physiotherapeut*innen in der ambulanten Schlaganfallrehabilitation: eine Querschnittsumfrage in Baden-Württemberg und Thüringen
Authors: Diermayr Gudrun , Schomberg Maria , Barthelmes Lisa-Sophia , Greisberger Andrea , Elsner Bernhard , Salbach Nancy Margaret 
Published: October 2021

Abstract

Objective
Guidelines recommend task-oriented training and the use of standardized assessments to improve stroke-related mobility deficits. However, the German outpatient physical therapy prescription catalogue does not include these recommendations resulting in a possible gap between guideline recommendations and clinical practice. Therefore, the purpose of this study was to describe physical therapy practice patterns of stroke-related mobility deficits in the outpatient setting exemplified by the states Baden-Württemberg and Thuringia.

Methods
Using an online survey, physical therapists treating people with stroke in outpatient settings in Baden-Württemberg and Thuringia were recruited. The questionnaire was developed using a multi-step procedure. Using a case vignette and open-ended questions, preferred evaluation and treatment methods were assessed. Data were analyzed using content analysis and descriptive statistics.

Results
Data from 63 physical therapists were included in the analysis. Answers to the open questions showed a wide range of different citations. Of 186 citations on evaluation methods, 28 (15,1 %) were classified as “standardized assessments”, while 158 citations (84,9 %) were classified as “basic physical therapy evaluation (non-standardized)”. Standardized assessments were cited by 25% of participants. Of 182 citations on treatment methods, 69 (35,2%) were classified as “traditional therapies”. These traditional therapies were cited by 81 % of participants. Task-oriented training was not cited.

Discussion
Despite the small sample size our data confirm the insufficient guideline use in German physical therapy and contribute results on practice patterns in outpatient stroke settings. These results will be used to initiate theory-based implementation strategies aiming to optimize physical therapy for people with stroke.
Anterior prompt for debridement and myoplasty femoral neck and head osteomyelitis
Authors: Bensman V. M. , Savchenko Yu. P. , Malyshko V. V. 
Published: October 2021

The known anterior prompts to the femoral neck are non-traumatic, but they exclude the possibility of myoplasty and are not large enough for intra-articular sequestrectomy.Objective. The aim of the study was to develop an anterior prompt to the hip joint for sequestrectomy with myoplasty.Materials and research methods. For surgery neck and head of the hip osteomyelitis we perform a semi-oval incision in the projection of the femoral head, from the anterior spines of the ilium we cut off the tendons of the sartorius and rectus head of the quadriceps femoris muscles. An operating field is formed, which allows sequestrectomy to be performed. Plasty of the osteomyelitis cavity is performed with the proximal parts of the two anterior ileofemoral muscles. The operating field, if necessary, can be increased by temporary transection of the lumbar-iliac muscle tendon.Research results. The key to the anterior surgical prompt to the hip joint is the sartorius and rectus head of the quadriceps. The length of the surgical wound reaches 17–22 cm, and the width is 16–18 cm. With the mobilized proximal part of the sartorius muscle, we fill the entire bone cavity in the neck and head of the femur. Of the 12 operated patients, 11 (91.7 ± 7.6 %) had a stable long-term remission.Conclusion. The proposed approach is less traumatic and allows you to operate at an angle of about 90°. It complements the advantages of the known anterior prompts and is devoid of their disadvantages.
Kajian Peletakan Fungsi Vegetasi Terhadap Kondisi Ruang Terbuka Kampus (Studi Kasus: Indonesia Port Corporation University, Ciawi, Bogor)
Authors: Regita Ratu Segi , Simangunsong Nur Intan , Chalim Abdul 
Published: October 2021

Ruang terbuka merupakan hal utama pada setiap aktifitas di ruang luar khususnya tempat yang padat pengguna dan memiliki beragam kegiatan seperti kampus. Fungsi ruang terbuka sebagai tempat berinteraksi, bermain, berolahraga, tempat bersantai dan tempat parkir. Selain itu ruang terbuka juga memiliki fungsi sebagai pengendali mikro klimat dan penyerapan air hujan. Dalam hal ini vegetasi berpengaruh pada setiap perencanaan ruang terbuka. Ruang terbuka kampus Indonesia Port Corporation University memiliki jenis dan aktifitas yang beragam, oleh karena itu peletakan pada vegetasi disetiap ruang terbuka kampus harus disesuaikan dengan fungsi dan kriterianya. Namun masih ada lokasi pada ruang terbuka kampus Indonesia Port Corporation University yang peletakan vegetasinya tidak sesuai dengan fungsi dan kriteria vegetasi tersebut. Penelitian dilakukan pada 4 lokasi dan 8 titik disetiap area ruang terbuka yang ditentukan berdasarkan purposive sampling. Metode yang digunakan pada penelitian yaitu kualitatif dengan literature review untuk mengetahui jenis dan fungsi vegetasi yang akan diteliti lalu untuk menentukan kriteria vegetasi yang sesuai dengan (1) fungsi peneduh (2) fungsi pengarah (3) fungsi penyerap polutan (4) fungsi estetika dan peletakan pada setiap ruang terbuka kampus dilakukan menggunakan metode kuantitatif Key Performance Index (KPI). Hasil dari penelitian peletakan vegetasi dengan fungsi peneduh yang memiliki nilai scor tertinggi ada pada lokasi 1 yaitu tempat yang digunakan sebagai tempat parkir (66,25%) karena didalamnya didominasi pohon tanjung dengan kriteria pola peletakan tanaman yang ditanam berbaris dan bermassa daun padat. Lokasi 3 memiliki scor tertinggi (80%) yang peletakan vegetasinya sebagai fungsi pengarah karena didominasi oleh vegetasi bertajuk kolumnar dan ditanam secara berbaris. Peletakan vegetasi yang sesuai dengan fungsi sebagai penyerap polutan terdapat pada lokasi 4 (67,85%)dimana kriteria vegetasi yang mendominasi yaitu bermassa daun padat dan percabangannya menyebar. Sedangkan untuk peletakan vegetasi dengan fungsi estetika terdapat pada lokasi 3 (88,33%) karena pada lokasi ini didominasi oleh vegetasi dengan kriteria bentuk tajuk serta percabangan menarik dan terdapat variasi warna terhadap (daun, batang,bunga dan buah). Penelitian ini menunjukkan bahwa peletakan vegetasi sangat mempengaruhi kondisi ruang terbuka suatu tapak untuk itu diperlukan kajian mengenai fungsi dan kriteria vegetasi sebelum perencanaan pengembangan suatu kawasan pada tapak.
Risk Factors and Characteristics of Adverse Reactions Associated with the Use of Beta-Lactam Antibiotics in Older Patients
Authors: Sokova E. A. , Arkhipov V. V. , Demidova O. A. , Mazerkina I. A. , Alexandrova T. V. , Zhuravleva M. V. 
Published: October 2021

The frequency of adverse drug reactions (ADRs) in older patients is approximately 11.0%, according to scientific literature. Antibiotics are the third largest group (19.5%) of medicinal products in terms of ADR frequency in geriatric patients. Beta-lactam antibiotics are the empiric treatment of choice for older outpatients and inpatients with community-acquired pneumonia. The mortality in this group of patients accounts for 85% of the overall mortality from community-acquired pneumonia. The aim of the study was to analyse scientific data on risk factors and characteristics of adverse drug reactions associated with the use of beta-lactam antibiotics in older patients. Specificity of ADRs to beta-lactam antibiotics in this group of patients is due to age-related changes in pharmacokinetics and pharmacodynamics as well as polymorbidity and polypharmacy. The analysis of scientific literature demonstrated that there have not been so many pharmacoepidemiological studies in this group of patients, and their results have been inconsistent. The frequency, causes, and clinical manifestations of ADRs in geriatric patients are diverse and differ considerably from those in younger patients. Of the most widely used antibiotics, ceftriaxone and cefaclor exhibited a statistically lower risk of ADRs in older patients than in younger patients. At the same time, ceftriaxone was associated with a relatively higher frequency of serious ADRs in older patients as compared to younger patients, whereas the frequency of serious ADRs was lower with cefaclor. The likelihood of nephrotoxic, neurotoxic, and hepatotoxic ADRs associated with the use of beta-lactam antibiotics is becoming more and more obvious but it is still underestimated in clinical and geriatric practice. Safety monitoring, therapeutic drug monitoring with due consideration of ADR risk factors in older patients, and inclusion of older patients in clinical trials of antimicrobial drugs, would improve efficacy and safety of antibiotic treatment.
The Impact of the Covid-19 Pandemic on Mental Condition and the Need for Psychological Support of Students in Jakarta
Authors: Susanto Susanto 
Published: October 2021

<p class="abstrak" align="center"><strong>Abstract</strong><strong><em></em></strong></p><p class="abstrak">The Covid-19 pandemic situation has demanded all aspects to adjust. Students are forced to make various adjustments, both learning patterns, demands for adapting new habits, and adherence to health protocols. However, the mental impact on students is not yet known. This study aims to identify the impact of the Covid-19 pandemic on the mental condition of students and the need for psychological support needed for students. This study uses a qualitative method with data collection techniques through online surveys with the target of student respondents coming from Jakarta and the selection of respondents is random and the analysis is carried out descriptively. This study found that the impact of the Covid-19 pandemic on the mental condition of students in Jakarta included; feelings of boredom, confusion, fear, anxiety, and stress. The support needed for students facing the Covid-19 pandemic is family support, friend support, and facility support to carry out positive activities.</p><p class="abstrak"> </p><p class="abstrak"><em>Situasi pandemi Covid-19 telah menuntut semua aspek untuk menyesuaikan. Peserta didik dituntut melakukan berbagai penyesuaian, baik pola belajar, tuntutan adaptasi kebiasaan baru serta kepatuhan pada protokol kesehatan. Namun demikian, belum diketahui dampak secara mental terhadap peserta didik di Jakarta. Penelitian ini bertujuan untuk mengidentifikasi dampak pandemi covid-19 terhadap kondisi mental peserta didik dan kebutuhan dukungan psikologis yang diperlukan bagi peserta didik. Penelitian ini menggunakan metode kualitatif dengan teknik pengumpulan data melalui survey secara online dengan sasaran responden peserta didik berasal dari Jakarta dan pemilihan responden secara random serta analisis dilakukan secara deskriptif. Penelitian ini menemukan bahwa dampak pandemi covid-19 terhadap kondisi mental peserta didik di Jakarta meliputi; perasaan bosan, bingung, ketakutan, cemas dan stress. Dukungan yang diperlukan bagi peserta didik menghadapi pandemi covid-19 yaitu dukungan keluarga, dukungan teman dan dukungan fasilitas untuk melaksanakan kegiatan positif. </em></p>
Enhancing Waqf Forest Sustainability Through Agroforestry: Case Study from Bogor Waqf Forest, Bogor, Indonesia
Authors: Jannah Miftahul , Ali Khalifah Muhamad , Fatria Brigita Laura , Sarkawi Azila Ahmad , Othman Jamilah 
Published: October 2021

<p class="abstrak">The high rate of forest conversion in Indonesia required further actions to overcome. One of the solutions is through waqf (endowment) forest, a forest developed on waqf land. According to Islamic law, a waqf forest cannot be sold, granted, inherited, or changed unreasonably. Previous researches generally focused more on the potential and prospect of cash waqf or land waqf for forest protection. On the other hand, a study to enhancing waqf forest sustainability still needs to be developed, especially in Indonesia. This paper aims to observe the practice of agroforestry to enhance the sustainability of waqf forest, with the case study location in the Bogor Waqf Forest, Cibunian Village, Pamijahan District, Bogor Regency, Indonesia. The present study was conducted from March 2019 until June 2021, using a literature study, observation, and in-depth interview method then analyzed descriptively. Agroforestry practices are chosen in the case study location, such as agrosilvicultural, agrosilvopastoral, and agrosilvofishery. Based on the Sustainable Forest Management (SFM) goals, agroforestry practices in waqf forests are estimated to extend forest resources, increase biodiversity, forest health, forest production, and protection functions, and contribute to social and economic development benefits.</p><p class="abstrak"> </p><p><em>Tingginya alihfungsi lahan hutan di Indonesia memerlukan usaha lebih untuk mengatasinya. Salah satu solusinya adalah melalui program hutan wakaf, yaitu hutan yang dibangun di atas tanah wakaf. Berdasarkan hukum Islam, hutan wakaf tidak boleh dijual, diberikan, diwariskan, dan diubah fungsi lahannya tanpa alasan yang </em><em>dibenarkan</em><em>. Penelitian-penelitian sebelumnya lebih berfokus pada potensi dan prospek dari wakaf uang atau wakaf tanah untuk melindungi hutan. </em><em>S</em><em>tudi mengenai upaya pelestarian hutan wakaf masih perlu untuk dilakukan, terutama di Indonesia. Studi ini dilakukan pada bulan Maret tahun 2019</em><em> hingga Juni tahun 2021,</em><em> </em><em>ber</em><em>lokasi </em><em>di Hutan Wakaf Bogor, </em><em>Desa Cibunian, Pamijahan, Kabupaten Bogor, Indonesia</em><em>,</em><em> menggunakan metode studi literatur, observasi lapang, dan wawancara pakar yang kemudian dianalisis secara deskriptif. </em><em>Beberapa p</em><em>raktik </em><em>agroforestri</em><em> </em><em>dipilih untuk diaplikasikan pada lokasi studi</em><em>, seperti agrosilvikultura, agrosilvopastoral, dan agrosilvofishery</em><em>. Berdasarkan tujuan pengelolaan hutan lestari (SFM), praktik agroforest</em><em>r</em><em>i pada hutan wakaf diestimasikan tidak hanya meningkatkan sumber daya hutan, biodiversitas, kesehatan, produksi, dan perlindungan hutan, tetapi juga memiliki manfaat sosial dan ekonomi.</em></p>
Stream-based explainable recommendations via blockchain profiling
Authors: Leal Fátima , Veloso Bruno , Malheiro Benedita , Burguillo Juan C. , Chis Adriana E. , González-Vélez Horacio 
Published: October 2021

Explainable recommendations enable users to understand why certain items are suggested and, ultimately, nurture system transparency, trustworthiness, and confidence. Large crowdsourcing recommendation systems ought to crucially promote authenticity and transparency of recommendations. To address such challenge, this paper proposes the use of stream-based explainable recommendations via blockchain profiling. Our contribution relies on chained historical data to improve the quality and transparency of online collaborative recommendation filters – Memory-based and Model-based – using, as use cases, data streamed from two large tourism crowdsourcing platforms, namely Expedia and TripAdvisor. Building historical trust-based models of raters, our method is implemented as an external module and integrated with the collaborative filter through a post-recommendation component. The inter-user trust profiling history, traceability and authenticity are ensured by blockchain, since these profiles are stored as a smart contract in a private Ethereum network. Our empirical evaluation with HotelExpedia and Tripadvisor has consistently shown the positive impact of blockchain-based profiling on the quality (measured as recall) and transparency (determined via explanations) of recommendations.
The association of lower trunk muscle strength with low back pain in elite lightweight judokas is dependent on lumber spine abnormalities
Authors: Okada Takashi , Iwai Kazunori , Hakkaku Takayoshi , Nakazato Koichi 
Published: October 2021

BACKGROUND: Lumbar radiological abnormalities (LRA) and trunk muscle weakness are major causes of the low back pain (LBP). We reported that the prevalence of LRA was approximately 90% in middle- and heavyweight-judokas, independent to the occurrence of LBP. However, the trunk muscle weakness, especially the rotators, plays a key role in occurrence of LBP in heavyweight judokas. OBJECTIVE: To examine the trunk muscle strength (TMS) and LRA impact on LBP occurrence in lightweight judokas. METHOD: The strength of the trunk extensors, flexors, and rotators was measured in 32 lightweight male judokas. LBP and LRA were identified using a questionnaire, X-ray, and MRI. RESULTS: The occurrence rate of LBP and LRA were 40.6% and 62.5%, respectively, without any significant correlation. Among judokas without LRA, TMS of those with LBP were significantly lower than those without LBP ([Formula: see text] 0.05, the extensor; 60[Formula: see text]/s: ES [d] [Formula: see text] 1.38, 90[Formula: see text]/s: ES [d] [Formula: see text] 0.78, and 120[Formula: see text]/s: ES [d] [Formula: see text] 0.37, flexor; 60[Formula: see text]/s: ES [d] [Formula: see text] 1.48, dominant rotator; 60[Formula: see text]/s: ES [d] [Formula: see text] 1.66, and 90[Formula: see text]/s: ES [d] [Formula: see text] 1.87, non-dominant rotator; 90[Formula: see text]/s: ES [d] [Formula: see text] 0.17, and dominant/non-dominant rotator ratio; 90[Formula: see text]/s: ES [d] [Formula: see text] 1.55). Moreover, there were significant negative correlations between LBP severity and TMS ([Formula: see text] 0.05, the extensor; 90[Formula: see text]/s: [Formula: see text] [Formula: see text]0.63, dominant rotator; 90[Formula: see text]/s: [Formula: see text] [Formula: see text]0.648, and dominant/non-dominant rotator ratio; 90[Formula: see text]/s: [Formula: see text] [Formula: see text]0.621) in judokas without LRA. CONCLUSION: Weak trunk musculature may be a co-factor in the occurrence of LBP in lightweight judokas without LRA.
The presence of herpesviruses in malignant but not in benign or recurrent pleomorphic adenomas
Authors: Jauhiainen Maria K. , Xu Man , Pyöriä Lari , Atula Timo , Aro Katri , Markkanen Anttoni , Haglund Caj , Hagström Jaana , Mäkitie Antti A. , Söderlund-Venermo Maria , Sinkkonen Saku T. 
Published: October 2021

BACKGROUND: The etiology of salivary gland tumors is mainly unknown. The anatomical location of the salivary glands, with the mucosal pathway to the oral cavity and its rich microbiome, raises the question of potential viral background. OBJECTIVE: This study focuses on the potential presence of herpes-, polyoma- and parvoviruses in pleomorphic adenoma (PA), recurrent pleomorphic adenoma (RPA) and carcinoma ex pleomorphic adenoma (CaxPA). METHODS: Thirty different viruses were analyzed by PCR-based assays in 68 formalin-fixed paraffin-embedded salivary gland tumors (25 PA, 31 RPA and 12 CaxPA). RESULTS: Virus DNA was detected altogether in 19/68 (28%) tumor samples. Human herpesviruses 6B and 7 (HHV-6B and HHV-7) and Epstein-Barr virus (EBV) were frequently and almost exclusively found in CaxPA (5/12, 7/12, and 3/12, respectively). Within the 7 CaxPA that were virus-positive, 3 samples contained 3, and 1 sample even 4, different viruses. Infrequent viral positivity was shown for parvovirus B19 and cutavirus, as well as Merkel cell and Malawi polyomaviruses. CONCLUSIONS: Our unexpected finding of herpesvirus DNA almost exclusively in CaxPA tissues deserves further in-depth studies.