bluuebunny/crossref_metadata_2025_split huggingface dataset:
KECEMASAN PADA IBU HAMIL TERHADAP KUNJUNGAN ANC DI ERA PANDEMI COVID-19
Authors: Silvian Mega , Ekasari Tutik 
Published: October 2021

Indonesia merupakan salah satu negara yang terjangkit pandemi Corona Virus Disease-19 (Covid-19) dengan angka kejadian terkonfirmasi Covid-19 (kasus baru) yang bertambah secara fluktuatif. Pemberian layanan maternal di masa pandemi perlu menjadi perhatian untuk menghindari terjadi peningkatan morbiditas dan mortalitas ibu, terlebih saat ini terdapat pembatasan pelayanan kesehatan maternal. Hal ini bisa menjadi faktor penyebab kecemasan yang terjadi pada ibu hamil. Tujuan dari penelitian ini untuk menganalisa hubungan antara kecemasan pada ibu hamil dengan kunjungan ANC di era pandemi covid-19. Merupakan penelitian analitik dengan rancang bangun menggunakan cross sectional. Populasi pada penelitian ini adalah semua ibu hamil yaitu sebanyak 37. Teknik Sampling dalam penelitian ini menggunakan total sampling. Sampel: semua ibu hamil yaitu sebanyak 37. Pengumpulan data dengan menggunakan kuesioner dan kecemasan diukur dengan HARS, dan dianalisa dengan Univariat dan bivariat dengan chi-square. Hasil uji statistik diperoleh nilai p=0,011 sehingga dapat diartikan bahwa ada hubungan antara kecemasan dengan kunjungan ANC di era pandemi covid 19.
EFEKTIVITAS STRETCHING ABDOMINAL DALAM PENGURANGAN NYERI AKIBAT DYSMENORRHEA PRIMER PADA REMAJA
Authors: Purwantini Dwi 
Published: October 2021

Background: Abdominal stretching is a stretching that focusing on the part of abdominal muscle (rectus abdominis, internus obliqus, external obliqus). Stretching is successful in reducing dysmenorrhea complaint. The aim of research to analyse the influence of abdominal stretching on reducing the level of primary dysmenorrhea. Methods: The studied design used was quasi experimental with pre and post control design. Subyek were 40 female physiotherapy student with primary dysmenorrhea devided into two groups. The experimental grup get abdominal stretching 10-15 minutes Results: The result of the researt showed that the control group had a p value = 0.52, which means that Ho is accepted, so the hypothesis states that there is no effect on the decrease in VDS scores. The treatment group p = 0.00 Ho was rejected and Ha was accepted so the hypothesis stated that abdominal atretching had an effect on the impairment of VDS. Conclusion: abdominal stretching was effective in reducing level of primary dysmenorrhea
Indicators of scientific publications on entrenchment:
Authors: Dias Mendes Costa Silas 
Published: October 2021

The aim of this paper is to carry out a bibliometric analysis of the literature on organizational entrenchment in the SPELL database between 2011 and 2020. Our methodology is descriptive, quantitative-qualitative, and the data are analyzed using bibliometrics. 32 articles were identified, submitted to selection and analysis criteria. The research identified a variation on the professional profile of its participants, featuring civil servants with a higher percentage. Methodological characteristics that stand out include the empirical nature, the quantitative approach, the use of questionnaires, multivariate data analysis, and studies in an organization. These results contribute to expand knowledge by allowing a broader view and analysis of the literature by indicating the main authors, journals, participating workers, and methodological aspects used.
Increased Intraocular Pressure in Glaucomatous, Ocular Hypertensive, and Normotensive Space Shuttle Crew
Authors: Dalal Sawan R. , Ramachandran Vignesh , Khalid Radina , Keith Manuel F. , Knowles Julianne R. , Jones Jeffrey A. 
Published: October 2021

BACKGROUND: Glaucoma and ocular hypertension (OHT) are prevalent diseases with baseline intraocular pressure (IOP) elevations that future astronauts and spaceflight participants may suffer from. Preflight, in-flight, and postflight IOP measurements were collected aboard two U.S. Space Shuttle Program missions in normotensive control, OHT, and glaucomatous crewmembers.

METHODS: Five subjects (three controls, one glaucomatous, one OHT) were studied aboard 2-wk Space Shuttle missions. Baseline IOP (triplicate; handheld tonometry) was recorded during training 1–2 mo preflight, in flight (1–14 d), and postflight (3–29 d). Subjective symptoms were recorded via questionnaires. Data were analyzed using a spreadsheet with two-sample t-tests. P-value < 0.05 determined significance.

RESULTS: IOP increased for all in-flight vs. preflight measurements for controls (N = 3, +48.9%, +16.9%, +5.85%), OHT (N = 1, +20.3%), and glaucomatous (N = 1, +32.2%) groups. IOP eventually returned to baseline postflight [Return (R)+3–5 d], except for the astronaut with OHT (R+9–17). Subjective symptoms, likely multifactorial, included blurred vision, decreased visual acuity, and headaches.

DISCUSSION: IOP increased during spaceflight and normalized upon return. Astronauts and commercial spaceflight participants may need screening for elevated IOP to potentially prevent sequelae related to glaucoma and OHT, the former which requires treatment in flight and the latter which may need prophylaxis. Previous studies have shown elevated IOP upon entry into microgravity with various normalization timeframes in flight and postflight. It is unclear how increased IOP relates to spaceflight-associated neuro-ocular syndrome (SANS); however, several hypotheses exist. Treatment strategies should be available for acute and chronic ocular pathology during spaceflight despite the unique challenges of eye-drop application in microgravity.

Dalal SR, Ramachandran V, Khalid R, Manuel FK, Knowles JR, Jones JA. Increased intraocular pressure in glaucomatous, ocular hypertensive, and normotensive space shuttle crew. Aerosp Med Hum Perform. 2021; 92(9):728–733.
One-Step Synthesis of Bifunctional Nickel Phosphide Nanowires as Electrocatalysts for Hydrogen and Oxygen Evolution Reactions
Authors: Xiang Dong , Zhang Biao , Zhang Hongsheng , Shen Liangping 
Published: October 2021

The Ni2P nanowires were simply synthesized via a rapid one-step hydrothermal approach, in which deionized water, red phosphorus, nickel acetate, and hexadecyl trimethyl ammonium bromide were used as the solvent, phosphor and nickel sources, and active agent, respectively. The as-synthesized Ni2P nanowire clusters were composed of uniform nanowires with length of about 10 μm and diameter of about 40 nm. The Ni2P nanowires exhibited enhanced electrocatalytic activity for both hydrogen evolution reaction and oxygen evolution reaction This work provides good guidance for the rational design of nickel phosphides with unique nanostructures for highly efficient overall water splitting.
The Effects of Chinese Medicine QRD, Antibiotics, and Probiotics on Therapy and Gut Microbiota in Septic Rats
Authors: Cao Huiling , Zong Chunhui , Dai Wenkui , Gao Qiaoying , Li Donghua , Wu Xianzhong , Li Dongfang , Tang Yi-Wei , Wu Shangwei 
Published: October 2021

Sepsis is a common and often treacherous medical emergency with a high mortality and long-term complications in survivors. Though antibiotic therapy can reduce death rate of sepsis significantly, it impairs gut microbiota (GM), which play imperative roles in human health. In this study, we compared the therapeutic effects of antibiotics, probiotics, and Chinese medicine QRD on the survival rates of septic model and observed the GM characteristics of experimental rats via 16S rRNA gene amplicon sequencing. The 72 h survival rates of septic rat demonstrated the significant therapeutic effects in the three groups treated with antibiotics (AT), Chinses medicine QRD (QT), and probiotics (PT), which were elevated from the survival rate of 26.67% for the sepsis control group (ST) to 100.0% for AT, 88.24% for QT, and 58.33% for PT. The original characteristics of GM identified in the sham operation controls (SC) were relatively similar to those in PT and QT; nevertheless, the AT rats were shown dramatically decreased in the GM diversity. In addition, the septic rats in AT were revealed the higher abundances of Escherichia Shigella, Proteus, Morganella, Enterococcus, and Lysinibacillus, but the lower those of Parabacteroides, Alistipes, Desulfovibrio, Bacteroides, Helicobacter, Mucispirillum, Oscillibacter, Lachnospiraceae, and Ruminiclostridium 9, when compared to the PT and QT rats. By contrast, the GM of PT and QT rats shared similar diversity and structure. Our findings indicated that QRD increased the survival rates without impairment of the GM characteristics, which provides novel insights into the role of Chinese medicine in therapy and long-term recovery of sepsis.
Assessment of New Coronary Features on Quantitative Coronary Angiographic Images With Innovative Unsupervised Artificial Adaptive Systems: A Proof-of-Concept Study
Authors: Amato Mauro , Buscema Massimo , Massini Giulia , Maurelli Guido , Grossi Enzo , Frigerio Beatrice , Ravani Alessio L. , Sansaro Daniela , Coggi Daniela , Ferrari Cristina , Bartorelli Antonio L. , Veglia Fabrizio , Tremoli Elena , Baldassarre Damiano 
Published: October 2021

Background and Purpose: The Active Connection Matrixes (ACMs) are unsupervised artificial adaptive systems able to extract from digital images features of interest (edges, tissue differentiation, etc.) unnoticeable with conventional systems. In this proof-of-concept study, we assessed the potentiality of ACMs to increase measurement precision of morphological structures (e.g., stenosis and lumen diameter) and to grasp morphological features (arterial walls) from quantitative coronary angiography (QCA), unnoticeable on the original images.Methods: Archive images of QCA and intravascular ultrasound (IVUS) of 10 patients (8 men, age 69.1 ± 9.7 years) who underwent both procedures for clinical reasons were retrospectively analyzed. Arterial features derived from “IVUS images,” “conventional QCA images,” and “ACM-reprocessed QCA images” were measured in 21 coronary segments. Portions of 1-mm length (263 for lumen and 526 for arterial walls) were head-to-head compared to assess quali-quantitative between-methods agreement.Results: When stenosis was calculated on “ACM-reprocessed QCA images,” the bias vs. IVUS (gold standard) did not improve, but the correlation coefficient of the QCA–IVUS relationship increased from 0.47 to 0.83. When IVUS-derived lumen diameters were compared with diameters obtained on ACM-reprocessed QCA images, the bias (−0.25 mm) was significantly smaller (p &lt; 0.01) than that observed with original QCA images (0.58 mm). ACMs were also able to extract arterial wall features from QCA. The bias between the measures of arterial walls obtained with IVUS and ACMs, although significant (p &lt; 0.01), was small [0.09 mm, 95% CI (0.03, 0.14)] and the correlation was fairly good (r = 0.63; p &lt; 0.0001).Conclusions: This study provides proof of concept that ACMs increase the measurement precision of coronary lumen diameter and allow extracting from QCA images hidden features that mirror well the arterial walls derived by IVUS.
Influenza Vaccination and the Risk of Ventricular Arrhythmias in Patients With Chronic Obstructive Pulmonary Disease: A Population-Based Longitudinal Study
Authors: Chen Chun-Chao , Lin Cheng-Hsin , Hao Wen-Rui , Yeh Jong-Shiuan , Chiang Kuang-Hsing , Fang Yu-Ann , Chiu Chun-Chih , Yang Tsung Yeh , Wu Yu-Wei , Liu Ju-Chi 
Published: October 2021

Backgrounds: Influenza vaccination could decrease the risk of major cardiac events in patients with chronic obstructive pulmonary disease (COPD). However, the effects of the vaccine on decreasing the risk of ventricular arrhythmia (VA) development in such patients remain unclear.Methods: We retrospectively analyzed the data of 18,658 patients with COPD (≥55 years old) from the National Health Insurance Research Database from January 1, 2001, to December 31, 2012. After a 1:1 propensity score matching by the year of diagnosis, we divided the patients into vaccinated and unvaccinated groups. Time-varying Cox proportional hazards regression was applied to assess the time to event hazards of influenza vaccination exposure.Results: The risk of VA occurrence was significantly lower in the vaccinated group during influenza season and all seasons [adjusted hazard ratio (aHR): 0.62, 95% CI: 0.41–0.95; aHR: 0.69, 95% CI: 0.44–1.08; and aHR: 0.65, 95% CI: 0.48–0.89, in the influenza season, non-influenza season, and all seasons, respectively]. Among patients with CHA2DS2-VASc scores (conditions and characteristics included congestive heart failure, hypertension, diabetes, stroke, vascular disease, age, and sex) of 2–3, receiving one time and two to three times of influenza vaccination were associated with lower risk of VA occurrence in all seasons (aHR: 0.28, 95% CI: 0.10–0.80; aHR: 0.27, 95% CI: 0.10–0.68, respectively). Among patients without stroke, peripheral vascular disease, and diabetes, a lower risk of VA occurrence after receiving one and two to three times vaccination was observed in all seasons. Among patients with a history of asthma and patients without a history of heart failure, ischemic heart disease, angina hypertension, or renal failure, a significantly lower risk of VA occurrence was observed after the first time of vaccination in all seasons.Conclusions: Influenza vaccination may be associated with lower risks of VA among patients with COPD aged 55–74. Further investigation is still needed to resolve this clinical question.
Sex Differences in Mitral Annular Calcification and the Clinical Implications
Authors: Seo Jiwon , Jeong Hyeonju , Cho Iksung , Hong Geu-Ru , Ha Jong-Won , Shim Chi Young 
Published: October 2021

Background: Heterogeneous mechanisms may contribute to the occurrence of mitral annular calcification (MAC), however, little is known about the sex differences in MAC and the clinical implications of these differences. This study aimed to investigate clinical and imaging differences of MAC according to sex.Methods: In total, 537 patients (221 men) with MAC were identified by transthoracic echocardiography at a single center from January 2012 to June 2016. Moderate-to-severe MAC was defined as calcification extent ≥120° of the mitral annulus. Significant functional mitral stenosis (MS) was defined as a transmitral mean diastolic pressure gradient ≥5 mmHg.Results: Women more frequently had moderate-to-severe MAC and concomitant mitral regurgitation than men; however, significant functional MS was comparable between sexes. In the logistic regression analysis, old age, uncontrolled hypertension, end-stage renal disease (ESRD), and obstructive hypertrophic cardiomyopathy were significantly associated with moderate-to-severe MAC in women, whereas ESRD and moderate-to-severe aortic stenosis were in men. In the Cox regression analysis, significant functional MS was associated with all-cause death in both sexes, although an independent association was found in only women.Conclusion: Women had more extended MAC than men. Significant functional MS was independently associated with unfavorable clinical outcomes in patients with MAC, which was more pronounced in women than in men.
Nomogram to Predict Left Atrial Thrombus or Spontaneous Echo Contrast in Patients With Non-valvular Atrial Fibrillation
Authors: Li Zhitong , Liu Quanbo , Liu Fei , Hidru Tesfaldet H. , Tang Yuqi , Cong Tao , Gao Lianjun , Yang Xiaolei , Xia Yunlong 
Published: October 2021

Background: The predictive power of the CHADS2 and CHA2DS2-VASc scores for the presence of Left atrial thrombus (LAT)/ spontaneous echo contrast (SEC) in non-valvular atrial fibrillation (NVAF) is modest. The aim of this analysis is to define clinical and ultrasonic variables associated with LAT/SEC and to propose nomograms for individual risk prediction.Methods: Data on 1,813 consecutive NVAF patients who underwent transesophageal echocardiography (TEE) from January 2016 to January 2021 were collected. The univariate and multivariate logistic regression analyses were used to construct a nomogram. We examined the predictive ability of the risk scores by calculating the area under the curve (AUC). Moreover, the performance of the nomogram was assessed with respect to calibration, discrimination, and clinical usefulness.Results: LAT/SEC was found in 260 (21.0%) and 124 (21.6%) patients in the training and validation cohorts, respectively. On multivariate analysis, independent factors for LAT/SEC were Age, left atrial diameter (LAD), left ventricular ejection fraction (LVEF), hypertension (HTN), previous stroke or transient ischemic attack, Non-paroxysmal AF and a nomogram was built based on these variables. The calibration curve for the probability of LAT/SEC showed good prediction agreement with actual observation. The nomogram achieved good concordance indexes of 0.836 and 0.794 in predicting LAT/SEC in the training and validation cohorts, respectively. Decision curve analysis demonstrated that the nomogram would be clinically useful.Conclusions: In this study, a nomogram was constructed that incorporated six characteristics of NVAF patients. The nomogram may be of great value for the prediction of LAT/SEC in NVAF patients.
Deep Learning for Classification and Selection of Cine CMR Images to Achieve Fully Automated Quality-Controlled CMR Analysis From Scanner to Report
Authors: Vergani Vittoria , Razavi Reza , Puyol-Antón Esther , Ruijsink Bram 
Published: October 2021

Introduction: Deep learning demonstrates great promise for automated analysis of CMR. However, existing limitations, such as insufficient quality control and selection of target acquisitions from the full CMR exam, are holding back the introduction of deep learning tools in the clinical environment. This study aimed to develop a framework for automated detection and quality-controlled selection of standard cine sequences images from clinical CMR exams, prior to analysis of cardiac function.Materials and Methods: Retrospective study of 3,827 subjects that underwent CMR imaging. We used a total of 119,285 CMR acquisitions, acquired with scanners of different magnetic field strengths and from different vendors (1.5T Siemens and 1.5T and 3.0T Phillips). We developed a framework to select one good acquisition for each conventional cine class. The framework consisted of a first pre-processing step to exclude still acquisitions; two sequential convolutional neural networks (CNN), the first (CNNclass) to classify acquisitions in standard cine views (2/3/4-chamber and short axis), the second (CNNQC) to classify acquisitions according to image quality and orientation; a final algorithm to select one good acquisition of each class. For each CNN component, 7 state-of-the-art architectures were trained for 200 epochs, with cross entropy loss and data augmentation. Data were divided into 80% for training, 10% for validation, and 10% for testing.Results: CNNclass selected cine CMR acquisitions with accuracy ranging from 0.989 to 0.998. Accuracy of CNNQC reached 0.861 for 2-chamber, 0.806 for 3-chamber, and 0.859 for 4-chamber. The complete framework was presented with 379 new full CMR studies, not used for CNN training/validation/testing, and selected one good 2-, 3-, and 4-chamber acquisition from each study with sensitivity to detect erroneous cases of 89.7, 93.2, and 93.9%, respectively.Conclusions: We developed an accurate quality-controlled framework for automated selection of cine acquisitions prior to image analysis. This framework is robust and generalizable as it was developed on multivendor data and could be used at the beginning of a pipeline for automated cine CMR analysis to obtain full automatization from scanner to report.
Study on the Stability of Coal Pillars Under the Disturbance of Repeated Mining in a Double-Roadway Layout System
Authors: Liu Shuaigang , Bai Jianbiao , Wang Xiangyu , Wang Guanghui , Wu Bowen , Li Yanhui , Zhao Jiaxin 
Published: October 2021

The double-roadway layout system, which is extensively applied in large mines, has the potential to significantly balance excavation-mining and improve mine ventilation and transportation capacity. However, the coal pillar in the double-roadway layout system is easily destabilized due to the disturbance of repeated mining, which has a significant impact on the safety and reliability of coal mines. This paper takes the coal pillar and its supporting structure of the double-roadway layout system as the research object, establishes a UDEC trigon numerical calculation model, and systematically corrects the input parameters, while explaining the excavation method of roadways and the simulation method of the supporting structure element. The numerical simulation results show that under the conventional support intensity conditions, the internal damage of the coal pillar during the excavation period is about 20%, while the internal damage to the coal pillar develops to 55% throughout the first-panel mining. During the disturbance of repeated mining, the damage in the coal pillar increased to 90%, and the coal pillar was already in a state of failure. Under the combined control of rock bolts and counter-pulled anchor cables, the coal pillar damage does not change significantly during the excavation and first-panel mining. During the disturbance of repeated mining, the damage of the coal pillar is reduced to 63%. There is a certain low damage area in the coal pillar, which can ensure the stability of the coal pillar and its supporting structure as a whole. Furthermore, the on-site monitoring results show that the maximum value of the floor-to-roof and rib-to-rib convergence of a W1310 tailgate during the repeated mining disturbance stage is 730 and 620 mm, respectively. The findings of this study give an approach to—as well as estimated values for the design of, including its “small structure” control technical parameters—the double-roadway layout system.
Studies on Novel Diagnostic and Predictive Biomarkers of Intrahepatic Cholestasis of Pregnancy Through Metabolomics and Proteomics
Authors: Dong Ruirui , Ye Ningzhen , Zhao Shaojie , Wang Gaoying , Zhang Yan , Wang Tiejun , Zou Ping , Wang Jing , Yao Tingting , Chen Minjian , Zhou Conghua , Zhang Ting , Luo Liang 
Published: October 2021

BackgroundIntrahepatic cholestasis of pregnancy (ICP) usually occurs in the third trimester and is associated with increased risks in fetal complications. Currently, the exact mechanism of this disease is unknown. The purpose of this study was to develop potential biomarkers for the diagnosis and prediction of ICP.MethodsWe enrolled 40 pregnant women diagnosed with ICP and 40 healthy pregnant controls. The number of placental samples and serum samples between the two groups was 10 and 40 respectively. Ultra-performance liquid chromatography tandem high-resolution mass spectrometry was used to analyze placental metabolomics. Then, we verified the differentially expressed proteins and metabolites, both placental and blood serum, in the first, second, and third trimesters.ResultsMetabolomic analysis of placental tissue revealed that fatty acid metabolism and primary bile acid biosynthesis were enriched. In the integrated proteomic and metabolomic analysis of placental tissue, peroxisomal acyl-CoA oxidase 1 (ACOX1), L-palmitoylcarnitine, and glycocholic acid were found to be three potential biomarkers. In a follow–up analysis, expression levels of both placental and serum ACOX1, L-palmitoylcarnitine, and glycocholic acid in both placenta and serum were found to be significantly higher in third-trimester ICP patients; the areas under the ROC curves were 0.823, 0.896, and 0.985, respectively. Expression levels of serum ACOX1, L-palmitoylcarnitine, and glycocholic acid were also significantly higher in first- and second-trimester ICP patients; the areas under the ROC curves were 0.726, 0.657, and 0.686 in the first trimester and 0.718, 0.727, and 0.670 in the second trimester, respectively. Together, levels of the three aforementioned biomarkers increased the value for diagnosing and predicting ICP (AUC: 0.993 for the third, 0.891 for the second, and 0.932 for the first trimesters).ConclusionsL-palmitoylcarnitine, ACOX1, and glycocholic acid levels taken together may serve as a new biomarker set for the diagnosis and prediction of ICP.