bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined Elevation of Temperature and CO2 Levels Impacts the Production and Sugar Composition of Aphid Honeydew
Authors: Blanchard Solène , Verheggen François , de Vreken Isabelle Van , Richel Aurore , Detrain Claire 
Published: December 2021

Abstract
Honeydew is the keystone of many interactions between aphids and their predators, parasitoids, or mutualistic partners. Despite the crucial importance of honeydew in the aphid-ant mutualism, very few studies have investigated the potential impact of climate change on its production and composition. Here, we quantified changes in the sugar compounds and in the amount of honeydew droplets released by Aphis fabae reared on Vicia faba plants, under elevated levels of temperature and/or CO2. A combined elevation of these two abiotic factors increased honeydew production as well as the total amount in sugars, in particular the concentration of fructose and melezitose. Increased amount of sugars in phloem sap under elevated CO2 conditions, along with a raise of aphid metabolism and sap ingestion to compensate for water loss under elevated temperatures might explain these observed changes increase in honeydew production and sugar content. A higher amount of excreted honeydew coupled with a higher concentration in melezitose and fructose are expected to enhance both the feeding behavior and the laying of a recruitment trail by ant foragers, thereby reinforcing the ant-homopteran mutualism under a scenario of elevated temperature and CO2 levels. We discuss about the enhancing and counteracting effects of climate change on other biological agents (gut microorganisms, predators, parasitoids) that interact with aphids in a complex multitrophic system.
Acute Stress Induces Cerumen Secretion: Case series of Four Medical Students during Exams
Authors: Mohamed Rahma Sameh , Afify Mohamed , Kamal Manar Ahmed 
Published: December 2021

Abstract
Background and Objectives: Cerumen is a common physiological condition; it only becomes a problem if it causes a hearing impairment or other ear-related symptoms. There is increasing evidence for a relationship between stress and hearing problems. The study aims to understand the association between acute stress and increasing cerumen secretion among medical students during exams. Materials and Methods: The study is a retrospective, single-center, and consecutive case series conducted in Benha University Hospitals in Egypt We defined four cases of medical students who complained of earwax accumulation during their final exams from the 15th to the 13th of July 2021. Results: Four medical students participated in the study. Younger Females and males’ percentages were equal, and the mean age was 19.625 years old. Headache, ear discomfort, and ear pruritus are most common, followed by tinnitus, ear debris, and otitis media with effusion, while hearing loss, fever, and ear pain are slightly rare. The bilateral accumulation of earwax is typical than unilateral accumulation. Remowax was used in almost of cases and then ear wash. Males had high perceived stress, while females had moderate stress. Conclusions: This retrospective case series showed an association between acute stress and excessive cerumen secretion among small medical students during their final exams.
Social Networks and Internet Emotional Relationships on Mental Health and Quality of Life in Students: Structural Equation Modelling
Authors: Aliverdi Fatemeh , mahmoodi zohreh , Tourzani Zahra Mehdizadeh , Salehi Leili , Qorbani Mostafa , Mohamadi Farima 
Published: December 2021

Abstract
Background: Social networks and relationships create a sense of belonging and social identity and therefore have a major effect on mental health and quality of life, especially in young people. The present study was conducted to determine the predictor role of social networks and Internet emotional relationships on mental health and quality of life in students. Methods: The present cross-sectional study was conducted in 2021 on 350 students at Alborz University of Medical Sciences selected by convenience sampling. Data were collected using five questionnaires: Socioeconomic Status, Social Networks, Internet Emotional Relationships Mental Health, Quality of Life and a checklist of demographic details. Data were analyzed in SPSS-25, PLS-3, and Lisrel-8.8.Results: According to the path analysis results, mental health had the most significant positive causal relationship with Internet emotional relationships in the direct path (B=0.22) and the most negative relationship with socioeconomic status (B=-0.09). Mental health was assessed using DASS-21, in which higher scores mean higher mental disorders. Quality of life had the highest negative causal relationship with the DASS-21 score in the direct path (B=-0.26) and the highest positive relationship with socioeconomic status in the indirect path (B=0.023). The mean duration of using social networks (B=-0.067) and Internet emotional relationships (B=-0.089) had the highest negative relationship with quality of life.Conclusion: The use of the Internet and virtual networks, Internet emotional relationships and unfavourable socioeconomic status were associated with mental disorders and reduced quality of life in the students. Since students are the future of any country, it is necessary for policymakers to further address this group and their concerns.
Evaluation of Extracellular Volume by Computed Tomography is Useful for Prediction of Prognosis in Dilated Cardiomyopathy
Authors: Yashima Satomi , Takaoka Hiroyuki , Takahashi Manami , Kinoshita Makiko , Sasaki Haruka , Suzuki-Eguchi Noriko , Ota Joji , Nishikawa Yusei , Goto Hiroki , Kobayashi Yoshio 
Published: December 2021

Abstract
Purpose:

Dilated cardiomyopathy (DCM) is commonly encountered in daily clinical practice, and screening for coronary artery disease and other cardiomyopathies is necessary for its diagnosis. Cardiac CT is useful for the screening of coronary artery stenosis, and extracellular volume fraction (ECV) analysis by CT has become available using new specific software. Here, we evaluated the utility of ECV analysis using cardiac CT to predict patient prognosis in cases with DCM.
Methods:

We analyzed 70 cases with DCM and coronary computed tomography (CT) with available late-phase images. We evaluated the ECV of the left ventricular myocardium (LVM) using commercially available software (Ziostation 2, Ziosoft Inc, Japan).
Results:

ECV on LVM was 34.5±4.9%. Major adverse cardiac events (MACE) occurred in 20 cases (29%). ECV of the LVM on CT and the presence of significant valvular disease were significantly higher in cases with MACE than in those without (37.6±5.9 vs 33.2±3.9% and 55% vs 24%, P=0.0057 and P=0.013). LVEF was significantly lower in cases with MACE than in those without (22.3±7.6 vs 30.8±11.8%, P=0.0008). The best cut-off value of ECV on LVM for prediction of MACE was 32.7% based on receiver operating characteristics analysis. Cases with ECV ≥32.7% had significantly higher MACE based on Kaplan-Meier analysis (P=0.012). Only ECV on LVM was an independent predictor of MACE based on a Cox proportional hazards model (P=0.028).
Conclusion:

Evaluation of ECV on LVM by CT is useful for predicting MACE in patients with DCM.
A Pan-Cancer Analysis of the Tumorigenic Role of Yin-Yang1 (YY1) in Human Tumors
Authors: Pan Ke-Hao , Shi Nai-Peng , Liu Yi-Fan , Wang Ya-Li , Chen Ming 
Published: December 2021

Abstract
Background: Yin-yang1 (YY1) is a nuclear transcription factor possessing dual transcriptional activity, which has different expression in a variety of tumor tissues. However, it remains unclear that the role of YY1 in most tumors and its association with immune cell infiltration.Methods: The expression of YY1 was analyzed in pan-cancer data which were downloaded from The Cancer Genome Atlas (TCGA) database. The clinical survival data downloading from TCGA was used to analyze the effect of YY1 on clinical prognosis. We had access to the R package “clusterProfiler” to make the enrichment analysis of YY1. The score of the immune cell infiltration of TCGA samples was downloaded from published articles and the correlation between YY1 expression and the immune cell infiltration was analyzed.Results: YY1 had a high expression in 25 tumors and strongly associated with clinical stage. In most tumor types, the over-expression of YY1 was connected to the worse prognostic indicator, such as overall survival(OS), progression-free survival (PFS), disease-specific survival(DSS) and disease-free survival (DFS). Moreover, the expression of YY1 had a correlation with tumor mutation burden(TMB). Nearly all of immune-related genes had co-expression with YY1 and almost all genes had positive correlation with YY1 in all types of tumors. It's worth noting that the expression levels of B cells and T cells were lower in the group with high YY1 expression. In addition, 22 m6A methylation-related cells were co-expressed with YY1, such as METTL3, YTHDC1, FTO and so on. Conclusions: Our study leads to a suggestion that YY1 may be a marker of bad prognosis and high expression of YY1 may lead to immune infiltration and be connected to m6A methylation.
Fibromyalgia: epidemiology and risk factors, a population-based case-control study in Damascus, Syria.
Authors: Alzabibi Mhd Amin , Shibani Mosa , Alsuliman Tamim , Ismail Hlma , alasaad Suja , Torbey André , Altorkmani Abdallah , Sawaf Bisher , Ayoub Rita , khalayli Naram , Kudsi Mayssoun 
Published: December 2021

Abstract
Background

Fibromyalgia is a chronic disease with a high burden. We aim to be the first to investigate the prevalence of fibromyalgia (FM) in Syria and assess its risk factors.
Methods

a self-reported questionnaire was distributed to the public to identify fibromyalgia patients using the American College of Rheumatology (ACR) 2010 modified criteria. Identified cases were matched using age with controls free from rheumatic disorders that were randomly sampled from the same population.
Results

out of 2966 participants, 350 (11.8%) satisfied the diagnostic criteria. Of these, only 29 (8.2%) were previously diagnosed by a physician, 239 (68.3%) were females, and 69 (19.71%) were diagnosed with depression. Female sex (OR=1.7, CI: 1.3-2.1), unemployment (OR=1.4, CI:1.1 – 1.79), diagnosis of major depressive disorder (OR=3.8, CI: 2.7 – 5.35), generalized anxiety disorder (OR=2.7, CI: 1.95 – 3.72), and irritable bowel syndrome (OR=2.4, CI: 1.78 – 3.17) were significant risk factors for FM.
Conclusion

our study revealed one of the highest prevalence rates of fibromyalgia ever reported in the general population. Efforts must be intensified to increase the awareness about this disease in the Syrian society as well as among healthcare providers.
Hands and feet radiologic involvements in systemic sclerosis
Authors: Badiee Fatemeh , Fatemi Alireza , Zahedpasha Reza , Gharib Hadi , Jokar Mohammadhassan , Livani Somayeh , Aghaie Mehrdad , Abdolahi Nafiseh 
Published: December 2021

Abstract
Aim
Systemic sclerosis (SSc) is a rare autoimmune disorder characterized by vascular and fibrosing involvement of the skin and internal organs. In this study we determined the prevalence and characteristics of radiological hands and feet involvements in Iranian SSc patients identified disease–phenotype associations.
Methods
43 SSc patients (41 women and 2 men), with a median age of 44.79 years (ranges 26 to 70 years) and a mean disease duration of 11.78 years (ranges 2 to 28 years) were studied in this cross-sectional study.
Results
42 patients had radiological changes both in hands and feet. Only one patient had changes just in hand. The most frequent changes that we found in hand was Juxta-articular Osteoporosis (93%), Acro-osteolysis (58.2%), Joint Space Narrowing (55.8%). The prevalence of joint space narrowing or acro-osteolysis were higher in subjects with active skin involvement (modified Rodnan skin score (mRSS)>14) (16/21 v 4/16 for patients with inactive skin involvement (mRSS<14); p = 0.002). The most frequent changes that we found in foot were Juxta-articular Osteoporosis (93%), Acro-osteolysis (46.5%), Joint Space Narrowing (58.1%), subluxation (44.2%). The presence of anti-ccp antibody was detected in 4 (9.3%), while positive rheumatoid factor was found in 13 (30.2%) of SSc patients.
Conclusion
This study corroborates that an arthropathy is common in SSc patients. The introduction of the specific radiological involvements of SSc needs to be confirmed by further studies. in order to define the appropriate prognosis and treatment of patients.
Short- and long-range interactions in the HIV-1 5’UTR regulate genome dimerization and packaging
Authors: Smyth Redmond , Ye Liqing , Gribling Anne-Sophie , Bohn Patrick , Kibe Anuja , Börtlein Charlene , Ambi Uddhav , Ahmad Shazeb , Olguin-Nava Marco , Smith Maureen , Caliskan Neva , von Kleist Max 
Published: December 2021

Abstract
Genome dimerization is a conserved feature of retroviral replication and a critical step in the HIV-1 life cycle, but how it is regulated is incompletely understood. Here, we developed FARS-seq (Functional Analysis of RNA Structure) to comprehensively identify sequences and structures within the HIV-1 5’UTR influencing dimerization. We found nucleotides important for dimerization throughout the HIV-1 5’UTR and identified distinct structural conformations in monomeric and dimeric RNA. The dimer displayed TAR, PolyA, PBS, and SL1-SL3 as stem-loops. In the monomer, SL1 was dramatically reconfigured into long- and short-range base-pairings with polyA and PBS, respectively. The polyA-SL1 interaction disrupts the major packaging motifs, and the PBS-SL1 interaction functionally couples the primer binding site with dimerization and Pr55Gag binding. Altogether, our data provide insights into late stages of HIV-1 life cycle and a mechanistic explanation for the link between RNA dimerization and packaging.
A genome-wide association study to identify candidate genes for metabolic disorders in offspring by in vitro fertilization
Authors: Liu Lihong , Ha Siyao , Li MingQing , Li Zhiling 
Published: December 2021

Abstract
Background: In vitro fertilization (IVF) processes increase offspring's short-term and long-term health risks, but their mechanisms remain unclear. Methods: We conducted a bibliometric analysis to determine the landscape of IVF offspring health. Subsequently, a bioinformatics method was utilized to identify the co-genes properties and biological function mechanisms of IVF and type 2 diabetes mellitus (T2DM). Finally, we predicted compounds against key targets and performed multiple validations of the mechanisms underlying IVF offspring health risks. Results: We identified 15 genes associated with T2DM, and their biological functions are primarily associated with lipid metabolism. We also identified the properties of co-genes, modified characteristics, identified 3 SNPs sites, and determined the three core genes, APOA1, APOB, and APOE, which were mainly correlated with metabolic and cardiovascular diseases. In addition, we predicted drugs that may improve metabolic abnormalities in IVF offspring. Conclusions: The impact of aberrant lipid metabolism in offspring after IVF therapy warrants additional investigation, particularly in terms of long-term health consequences and possible mechanisms.
Pratylenchus smoliki, a new nematode species (Pratylenchidae: Tylenchomorpha) from the Great Plains region of North America
Authors: Powers Thomas , Todd Timothy , Harris Tim , Higgins Rebecca , MacGuidwin Ann , Mullin Peter , Ozbayrak Mehmet , Powers Kirsten , Sakai Kanan 
Published: December 2021

Abstract

Pratylenchus smoliki is a new species of root-lesion nematode described from corn-soybean production fields in the Central Great Plains of North America. It is characterized by populations with relatively abundant males, two lip annuli, females with a round functional spermatheca and a conoid to subcylindrical tail with a non-crenate, smooth terminus. In host preference tests, corn and wheat produce the largest nematode populations, whereas sorghum and soybeans produce less than 20% the numbers observed on corn. Scanning electron microscopy reveals that the en face patterns compare to those seen in Pratylenchus pseudocoffeae, P. scribneri, P. hexincisus, and P. alleni. The pattern is described as rectangular to trapezoidal subdorsal and subventral lips adjoining oral disc, but with a clear demarcation between the oral disc and the subdorsal and subventral sectors. A Maximum Likelihood COI tree recognizes P. smoliki as a moderately-well-supported clade with several haplotype subgroups. A Maximum Likelihood partial 28S tree provides strong support for the P. smoliki clade and reinforces the close relationships between species with similar en face patterns. Topotype specimens of P. alleni were demonstrably different from P. smoliki using DNA markers. The geographic range of P. smoliki overlaps with the ranges of P. alleni, P. scribneri, P. neglectus, P. hexicisus, and P. dakotaensis. The observed host range (corn, rye, sunflower, and wheat) suggests that P. smoliki may be native to the tallgrass prairie region of the Great Plains.
Detecting, extracting and classifying foreign objects in inter-basin channels to ensure water supply safety
Authors: Chen Junjie , Liu Donghai 
Published: December 2021

Abstract
Foreign objects (e.g., livestock, rafting, and vehicles) intruded into inter-basin channels pose threats to water quality and water supply safety. Timely detection of the foreign objects and acquiring relevant information (e.g., quantities, geometry, and types) is a premise to enforce proactive measures to control potential loss. Large-scale water channels usually span a long distance and hence are difficult to be efficiently covered by manual inspection. Applying unmanned aerial vehicles for inspection can provide time-sensitive aerial images, from which intrusion incidents can be visually pinpointed. To automate the processing of such aerial images, this paper aims to propose a method based on computer vision to detect, extract, and classify foreign objects in water channels. The proposed approach includes four steps, i.e., aerial image preprocessing, abnormal region detection, instance extraction, and foreign object classification. Experiments demonstrate the efficacy of the approach, which can recognize three typical foreign objects (i.e., livestock, rafting, and vehicle) with a robust performance. The proposed approach can raise early awareness of intrusion incidents in water channels for water quality assurance.
Determinants of household water demand: a cross-sectional study in South West Nigeria
Authors: Oyerinde A. O. , Jacobs H. E. 
Published: December 2021

Abstract
Estimating residential water demand in developing countries is complicated by the unique nature of water supply, characterised by unequal access and multiple water sources. Using cross-sectional data obtained from a survey of 1,300 households, the determinants of residential water demand were predicted using a multiple linear regression model. The determinants include access to water, household size, trip number, monthly income, payment for water, educational qualification, trip time and house type. The determinants predicted daily water consumption with an F(9, 1,014) = 81.063, P &lt; 0.05, R2 = 0.450. Daily water consumption was found to be 2.8 times more per household and 4.4 times more per capita for those with on-site access, compared to those with off-site access. Moreover, consumption was influenced by the various water source categories.
Research on application of ecohydrology to disaster prevention and mitigation in China: a review
Authors: Fan Guangli , Xia Jun , Song Jinxi , Sun Haotian , Liang Dong 
Published: December 2021

ABSTRACT
In this paper, the ecohydrology measures including water management and interaction of ecological hydrology were considered to take a holistic view on the impact of climate, ecology, environment, and topography on different types of disasters. In the first step, the contents of the grim disaster situation and the information framework of ecohydrology with disasters were evaluated. Nest, the creation of ecohydrology and its work with related disasters were summarized. Three disasters including flood, drought, and geohazard were evaluated and three examples (Dujiangyan Irrigation Project, Karez, and Ecological slope) have been separately discussed for considering the concept of the problem. Depending on the characteristics and potential for an effect in different disasters, there needed to be some challenges and opportunities for ecohydrology facing related disasters in various fields, such as National Space Planning, Sponge City and the ‘One Belt And One Road’ Initiative. Finally, some valuable conclusions were drawn on the application of ecohydrology to disaster prevention and mitigation. Furthermore, the key systemic settings between water management, hydrology, and ecology were described, which is of the main importance for social disaster reduction, emergency management, and protection of accident prevention.
Experimental studies of iron transformations kinetics and autocatalysis during its physicochemical removal from underground water
Authors: Martynov S. Yu , Poliakov V. L. 
Published: December 2021

Abstract
The mathematical model of physicochemical iron removal from groundwater was developed. It consists of three interrelated compartments. The results of the experimental research provide information in support of the first two compartments of the mathematical model. The dependencies for the concentrations of the adsorbed ferrous iron and deposited hydroxide concentrations are obtained as a result of the exact solution of the system of the mass transfer equations for two forms of iron in relation to the inlet surface of the bed. An analysis of the experimental data of the dynamics of the deposit accumulation in a small bed sample was made, using a special application that allowed selection of the values of the kinetic coefficients and other model parameters based on these dependencies. We evaluated the autocatalytic effect on the dynamics of iron ferrous and ferric forms. The verification of the mathematical model was carried out involving the experimental data obtained under laboratory and industrial conditions.
Treatment of the Allura Red food colorant contaminated water by a novel cyanobacterium Desertifilum tharense
Authors: Gül Ülküye Dudu , Şenol Zeynep Mine , Ertit Taştan Burcu 
Published: December 2021

Abstract
The biosorption properties of a newly isolated and identified cyanobacterium called Desertifilum tharense were investigated in the current study. Following morphological and molecular identification (16S rRNA sequencing analysis), the food colorant removal potential of this new isolate was determined. Moreover, the isotherm, kinetic, and thermodynamic studies were performed, and also the biosorbent characterization was studied after and before colorant biosorption with Fourier transform infrared and scanning electron microscopy analysis. Additionally, the changes in chlorophyll content of the biosorbent were examined after and before colorant treatment. The newly isolated cyanobacterial biosorbent removed 97% of Allura Red food colorant/dye at 1,500 mg L−1 initial dye concentration successfully at optimal conditions. Langmuir isotherm and pseudo-second-order kinetic models were fitted with the biosorption of the dye. The D-R model showed that the biosorption process occurred physically. The chlorophyll-a content of the biosorbent was negatively affected by the biosorption. The newly isolated and identified cyanobacterium seems to be a successful candidate for use to treat highly dye concentrated wastewaters.