bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘A strong desire to get into the bands’
Authors: Watson Kevin M. 
Published: May 2021

ABSTRACT
This article considers thirteen manuscript letters from the Early Methodist Volume, a valuable collection of letters housed at the John Rylands Research Institute and Library, University of Manchester. The thirteen letters range from 19 May 1740 to June 1742. These manuscript letters give insight into lay Methodism, revealing conflict in the beginnings of the Evangelical Revival, developments in small group formation (especially the band meeting), pastoral care within the bands, and the pursuit of holiness in community in the early 1740s. This article shows the significance of the band meeting among Methodists connected to Charles Wesley in these crucial years.
Prototipo de techo ecológico a través de hidroponía con materiales reciclados de productos plásticos elaborados con tereftalato de polietileno (PET)
Authors: Hernández Durán Hernán José 
Published: May 2021

La investigación contempla un análisis sobre el impacto ambiental que sufre nuestro planeta por falta de un adecuado manejo de los desechos sólidos. En este caso nos referiremos a los productos elaborados con Tereftalato de Polietileno conocido como PET. Se trata de un plástico que por sí solo no es contaminante, pero por las grandes cantidades en que se produce causa un problema a mayor escala. Este material se utiliza, sobre todo, en botellas de agua, jugos y principalmente en las bebidas de soda, las que, si no reciben un tratamiento adecuado de reciclaje, afectan a nuestro planeta. En El Salvador, la industria de producción de este material se encuentra de manera activa, y no se logra reciclar el 100% de este producto. Solamente el 20% recibe tratamiento, mientras que el 80% restante es manejado inadecuadamente, siendo enterrado, quemado, botado en calles, quebradas, ríos, playas, etc., (Nuñez,2008) Es necesario que este material se utilice para otros fines. El sector de la construcción utiliza una gran diversidad de materiales y, por su durabilidad, facilidad de manejo y fácil acceso, podría utilizar el PET, para diversos fines. En la presente investigación se utilizará para la elaboración de un prototipo de techo ecológico a través de hidroponía con materiales reciclados de productos plásticos PET.
The Long-term Corrosion Behaviors of SLM 316L Stainless Steel Immersed in Artificial Saliva
Authors: LI Yanmei , LIU Chiate , LIANG Yaohua , CHEN Xiaotong , YANG Zhibiao , CHEN Yingjun 
Published: May 2021

The Selective Laser Melting (SLM) is an effective method to produce highly corrosion resistant Oral Alveolar Implants (OAI) by changing the scanning speed. Nevertheless, the long-term corrosion behavior of SLM 316L orthodontic bracket alloys in artificial saliva is overlooked in previous studies. In this study, 316L SS samples fabricated by SLM at different scanning speeds (800 mm/s, 1200 mm/s, and 1600 mm/s) were conducted a long-term (90 days) immersion test by being put into artificial saliva with three different pH values (pH 1.5, pH 4, and pH 6). The morphology, XRD and especially corrosion behavior of the samples fabricated by SLM and forging were investigated. The XRD results exhibit that high-speed scanning accelerates the cooling rate and inhibits the δ → γ phase transformation proceeding. Corrosion results show that the corrosion attack induced by pre-existing pores will expand through the crevices and break down the surface structure around the pores, leading to corrosion damage area to expand to several times of the original pore area. Besides, the mean corrosion rate of the sample at a scanning speed of 800 mm/s shows better corrosion resistance in artificial saliva of pH 4 and pH 6. Compared with wrought 316L SS samples, the SLM 316L SS samples had an obvious difference in the performance of corrosion rate and corrosion behaviors.
Greenhouse Automation Using Wireless Sensors and IoT Instruments Integrated with Artificial Intelligence
Authors: R. Shamshiri Redmond , A. Hameed Ibrahim , R. Thorp Kelly , K. Balasundram Siva , Shafian Sanaz , Fatemieh Mohammad , Sultan Muhammad , Mahns Benjamin , Samiei Saba 
Published: May 2021

Automation of greenhouse environment using simple timer-based actuators or by means of conventional control algorithms that require feedbacks from offline sensors for switching devices are not efficient solutions in large-scale modern greenhouses. Wireless instruments that are integrated with artificial intelligence (AI) algorithms and knowledge-based decision support systems have attracted growers’ attention due to their implementation flexibility, contribution to energy reduction, and yield predictability. Sustainable production of fruits and vegetables under greenhouse environments with reduced energy inputs entails proper integration of the existing climate control systems with IoT automation in order to incorporate real-time data transfer from multiple sensors into AI algorithms and crop growth models using cloud-based streaming systems. This chapter provides an overview of such an automation workflow in greenhouse environments by means of distributed wireless nodes that are custom-designed based on the powerful dual-core 32-bit microcontroller with LoRa modulation at 868 MHz. Sample results from commercial and research greenhouse experiments with the IoT hardware and software have been provided to show connection stability, robustness, and reliability. The presented setup allows deployment of AI on embedded hardware units such as CPUs and GPUs, or on cloud-based streaming systems that collect precise measurements from multiple sensors in different locations inside greenhouse environments.
Impact of Acid Suppression Therapy on Iron Supplementation in the Pediatric Intensive Care Unit
Authors: Hailstone Emily , Falkos Sheryl , Vidal Rosa , Jones K. Ashley , Gaillard Philippe R. , Fan Shirley , Chung Allison M. 
Published: May 2021

OBJECTIVE
We assessed the impact of acid suppression therapy (i.e., ranitidine or proton pump inhibitors) on iron supplementation and its ability to maintain or alter laboratory values that are commonly associated with anemia.

METHODS
This was a prospective, observational trial. The primary outcome was changes in serum iron levels from baseline. Secondary outcomes were changes in hemoglobin (Hgb) and hematocrit (Hct), transfusions, and maintenance of an alkalotic gastric pH.

RESULTS
Thirty-four patients (mean 24 ± 43 months) met inclusion criteria. The serum iron levels increased to 50.9 ± 24.6 mcg/dL by day 3. The mean difference from baseline was 1.5 mcg/dL (95% CI, 1.14–1.98, p = 0.0056). Gastric pH increased to 4.68 ± 1.49 on day 5. The mean Hgb and Hct increased on day 5 to 10 ± 1.06 g/dL and 29.6% ± 3.27%, respectively. The mean difference of Hgb was 1.15 g/dL (95% CI, 0.51–1.78, p = 0.0009). The mean difference of Hct was 3.04% (95% CI, 1.11–4.97, p = 0.0032).

CONCLUSIONS
The use of antacids along with oral ferrous sulfate supplementation did not affect the absorption of iron. Serum iron, Hgb, and Hct all showed statistically significant increases despite combined antacid and iron therapy. Thus, despite use of antacids, combination use showed increases in iron absorption.
Use of the NINJA (Nephrotoxic Injury Negated by Just-in-Time Action) Program to Identify Nephrotoxicity in Pediatric Patients with Cystic Fibrosis
Authors: Newton Elizabeth S. , Kurzen Emily A. , Linnemann Rachel W. , Shin Hyunjung S. 
Published: May 2021

OBJECTIVE
This study aims to use and evaluate the Nephrotoxic Injury Negated by Just-in-time Action (NINJA) program in hospitalized patients with cystic fibrosis (CF) at Children's Healthcare of Atlanta.

METHODS
This was a single-center study evaluating patients with CF who were hospitalized and admitted to the pulmonary service 4 months pre- and post-NINJA implementation. Postimplementation patients with high nephrotoxic medication (NTMx) exposure were identified using an electronic reporting tool that triggered the pharmacist to alert the medical team and recommend Monday/Wednesday/Friday serum creatinine (SCr) monitoring. High NTMx exposure was defined as 3 or more NTMxs given concurrently, or at least 3 consecutive days of IV aminoglycosides or vancomycin. Outcomes assessed were rate of SCr monitoring, NTMx exposure, and days of acute kidney injury (AKI) pre- and post-NINJA implementation.

RESULTS
A total of 19 patients and 25 high-NTMx exposures were identified both pre- and post-NINJA implementation. The SCr monitoring increased from 13% to 50% of NTMx exposure days in the pre- versus post-NINJA time frame. More NTMx exposure days occurred in the post-NINJA time frame, from 250 exposure days per 1000 patient days pre-NINJA to 521 post-NINJA. An increased incidence of AKI events and AKI days were noted post-implementation; however, these differences were not significantly different between the 2 groups.

CONCLUSIONS
Increased SCr monitoring for patients with NTMx exposure using NINJA uncovered more episodes of AKI. Increased prevalence of NTMx use was associated with increased rates of AKI. Increased SCr monitoring as a result of NINJA implementation may allow for earlier detection of AKI.
Perfil de resistência de microrganismos isolados em fones de ouvidos de alunos de uma instituição de ensino superior de Juazeiro do Norte-CE
Authors: Barros Felipe Raimundo Bezerra , Monteiro Maria de Fátima Guedes , Sousa Júnior Dárcio Luiz de , Aquino Pedro Everson Alexandre de , Saraiva Cícero Roberto Nascimento , Silva Leandro Maria Karollyna Do Nascimento , Macedo da Silva Rakel Olinda , Leandro Lívia Maria Garcia 
Published: May 2021

O objetivo do presente estudo foi avaliar o perfil de resistência de microrganismos isolados em fones de ouvidos de alunos de uma instituição de ensino superior (IES) de Juazeiro do Norte-CE. Foram adquiridas 40 amostras aleatoriamente com os discentes da IES e acondicionadas em tubos contendo solução salina, essas amostras foram levadas para o laboratório de microbiologia do Centro Universitário Dr. Leão Sampaio, onde foram abertos e inoculados em meio Brain Hair Infusion (BHI), onde foram incubados em estufa bacteriológica a 37 ºC. Após 24 horas foi realizado o semeio nos meios de cultura (Agar Manitol Salgado, Agar Sangue e Agar Eosina Azul de Metileno - EMB), posteriormente foram realizadas as provas bioquímicas para confirmação das espécies, por fim realizou-se o antibiograma utilizando os discos de Amicacina, Gentamicina, Ofloxacina, Oxacilina, Norfloxacina, Ciprofloxacina e Penicilina G. Foi observado que 100 % das amostras encontravam-se contaminadas por um ou mais tipos de microrganismos (12,5 % de Streptococcus sp, 70 % de Staphylococcus aureus, Staphylococcus coagulase negativa 30%, Citrobacter freundii 7,5 %, Enterobacter aerogenes 2,5 % e Cândida sp. 35 %). A partir do antibiograma foi possível observar resistência das cepas para os antibióticos Penicilina G e Oxacilina. Baseado nos resultados obtidos é necessário que os discentes tenham um cuidado maior com os fones de ouvidos uma vez que, eles mal higienizados podem aglomerar diversos tipos de bactérias resistentes e podem causar infecções no canal auditivo.
IMPACTOS FUNCIONAIS EM MULHERES COM SINTOMAS DE COMPRESSÃO NERVOSA NA ALTURA DO PUNHO
Authors: Da Cunha Giovana Marchezan , Estivalet Kátine Marchezan , Ponte Aline Sarturi , Delboni Miriam Cabrera Corvelo 
Published: May 2021

Objetivo: Avaliar a funcionalidade em mulheres que apresentam sintomas de síndrome nervosa compressiva na altura do punho. Métodos: A pesquisa tem abordagem quantitativa, de caráter descritivo. Para coleta de dados, usou-se o instrumento Boston Carpal Tunnel Questionnaire para mensurar a intensidade e a frequência das parestesias, além de avaliar o grau de habilidade para desempenhar algumas atividades; avaliação de sensibilidade da mão no território do nervo mediano com os Monofilamentos de Semmes-Weinstein; e avaliação de força muscular para três tipos de pinça, através do Teste do Esfigmomanômetro Modificado. Realizou-se a análise descritiva univariada dos dados. Resultados: Participação de 11 mulheres adultas e idosas. Obteve-se a presença de parestesias, como dormência e formigamento nas mãos, com prevalência de sintomas bilaterais, e nos casos unilaterais prevaleceu a mão direita - mão dominante na maioria das mulheres. Na mensuração da força muscular, as participantes com diagnóstico prévio obtiveram média menor, indicando perda da força muscular para realização das pinças. Na avaliação da sensibilidade, detectaram-se, em ambas as mãos, comprometimentos sensoriais para o território de inervação do nervo mediano. Com o estudo, perceberam-se limitações para algumas atividades de vida diária, evidenciando que a perda da funcionalidade da mão provocada pelos sintomas da compressão nervosa, acarreta prejuízos nas diversas áreas do desempenho ocupacional. Considerações Finais: Sintomas de compressão nervosa na altura do punho podem indicar a presença de Síndrome do Túnel do Carpo que causa impactos funcionais, principalmente na realização de atividades envolvendo o uso das mãos, em vista das alterações sensório-motoras.
O grau da doença e a idade são preditores independentes de mortalidade em indivíduos com doença pulmonar obstrutiva crônica
Authors: Da Silva Gabriele Dos Anjos Palagi , Dos Santos Tamires Daros , Steidl Eduardo Matias dos Santos , De Albuquerque Isabella Martins , Pasqualoto Adriane Schmidt 
Published: May 2021

Objetivo: Identificar os preditores de sobrevida em pacientes com DPOC. Métodos: Trata-se de um estudo observacional, longitudinal, prospectivo, realizado na unidade de reabilitação pulmonar de um Hospital Universitário, na região Central do Rio Grande do Sul, no período de outubro de 2018 a julho de 2019. A amostra da pesquisa foi composta por pacientes com doença pulmonar obstrutiva crônica, de ambos os sexos. Os pacientes foram avaliados em relação aos aspectos psicossociais, diagnósticos, composição corporal, percepção de dispneia (Modified Medical ResearchCouncil - mMRC), estado de saúde (questionário COPD Assessment Test - CAT), análises hematológicas e o Índice de Comorbidade de Charlson corrigido para idade (ICC-I) utilizado para determinar a sobrevida. Resultados: O ICC-I associou-se com taxas de monócitos (r=0,31; p=0,03). Semelhantemente, houve associação do IMC com o VEF1/CVF (r =0,32; p=0,03), bem como, entre valores da hemoglobina circulante com a taxa de sobrevida (r=0,31; p=0,04). Considerações finais: Os fatores preditores da mortalidade no grupo de estudo foram VEF1, idade.
Fatores motivacionais dos idosos para a prática de atividade física em projeto social de Teixeira-PB
Authors: Ângelo Elton Batista , Perônico Francisca Márcia Marques , Oliota-Ribeiro Leandro Sávio , Lira Rafaelle Cavalcante 
Published: May 2021

Objetivo: Investigar os principais fatores motivacionais que influenciam a prática de atividade física pelos idosos, assim como a sua permanência na mesma. Métodos: Estudo de caráter Survey descritivo e transversal, com 20 idosos engajados em projeto social de incentivo a prática de atividade física na cidade de Teixeira-PB. Para determinar os principais fatores motivacionais foi utilizado o Inventário de Motivação a Prática Regular de Atividades Físicas (IMPRAF-54) questionário composto por 54 itens em nove blocos. Para a análise das variáveis e índices de normalidade foram utilizados o teste de Shapiro Wilk e o critério de Bartlett, foram tabelados e processados no programa GraphpadPrism 8.0.2., e o valor dos percentis foi obtivo através dos escores brutos de cada domínio em conformidade com a tabela normativa disponível no manual do IMPRAF-54. Resultados: Verificou-se que as principais motivações para o sexo feminino foram controle de estresse (41%), sociabilidade (28%), saúde (18%), competividade (17%), prazer (15%) e estética (13%), já para o sexo masculino as principais foram controle de estresse (76%), sociabilidade (53%), competividade (30%), saúde (25%), prazer (12%) e estética (1%), apenas o domínio controle de estresse (76%) no sexo masculino apresentou motivação alta de acordo o ponto de corte de classificação do presente estudo. Considerações Finais: As principais dimensões motivacionais dos idosos a praticarem e se manterem na atividade física foram o controle de estresse, sociabilidade, busca por saúde, competitividade, prazer e estética. Assim, mostra-se a importância do profissional em educação física em realizar atividades físicas que gerem interações sociais, sejam agradáveis e que visem proporcionarem uma melhora biopsicossocial para o indivíduo.
Prevalência de disfunção sexual e incontinência urinária em indivíduos cardiopatas candidatos à reabilitação cardíaca e indivíduos sem evento cardíaco prévio
Authors: Albuquerque Isabella , Bittencourt Alyssia Hammel , Dos Santos Tamires Daros , Cardoso Dannuey Machado , Braz Melissa Medeiros 
Published: May 2021

Objetivo: Analisar a prevalência de disfunção sexual e incontinência urinária em sujeitos cardiopatas candidatos a um programa de reabilitação cardíaca (PRC), assim como comparar os achados a sujeitos sem evento cardíaco prévio (n=25) e correlacionar com as variáveis capacidade funcional (CF) e qualidade de vida (QV). Métodos: Trata-se de um estudo transversal com avaliação dos seguintes desfechos: disfunção sexual (Female Sexual Function Index e Índice Internacional de Função Erétil Simplificado), incontinência urinária (International Consultation Incontinence Questionnaire – Short Form, Incontinence Severity Index), qualidade de vida (Minnesota Living with Heart Failure Questionnaire e MacNew Heart Disease Health-Related Quality of Life Questionnaire para sujeitos cardiopatas e Medical Outcomes Study 36-Item Short-Form Health Survey e Notthingam Health Profile para sujeitos sem evento cardíaco prévio) e CF (teste de caminhada de 6 minutos). Resultados: A amostra foi composta por 25 indivíduos cardiopatas candidatos a um PRC (59,88 ± 8,53 anos, 19 homens) e 25 indivíduos sem evento cardíaco prévio (57,88 ± 9,54 anos, 19 homens). Não houve diferença significativa na prevalência de disfunção sexual e incontinência urinária entre os grupos. Houve correlação inversa e forte (r=-0,803; p=0,005) entre disfunção sexual e CF nos homens cardiopatas. Os pacientes cardiopatas demonstraram uma menor capacidade funcional quando comparados aos sujeitos sem evento cardíaco prévio. Considerações Finais: Ressalta-se a importância da abordagem de temas como disfunção sexual e incontinência urinária dentro de um PRC, sobretudo em função do manejo precoce dos seus fatores de risco.
MicroRNA panel in serum reveals novel diagnostic biomarkers for prostate cancer
Authors: Zhang Shiyu , Liu Cheng , Zou Xuan , Geng Xiangnan , Zhou Xin , Fan XingChen , Zhu Danxia , Zhang Huo , Zhu Wei 
Published: May 2021

Purpose
MicroRNAs (miRNAs), which could be stably preserved and detected in serum or plasma, could act as biomarkers in cancer diagnosis. Prostate cancer is the second cancer in males for incidence. This study aimed to establish a miRNA panel in peripheral serum which could act as a non-invasive biomarker helping diagnosing PC.

Methods
A total of 86 PC patients and 86 normal control serum samples were analyzed through a four-stage experimental process using quantitative real-time polymerase chain reaction. Logistic regression method was used to construct a diagnostic model based on the differentially expressed miRNAs in serum. Receiver operating characteristic curves were constructed to evaluate the diagnostic accuracy. We also compared the 3-miRNA panel with previously reported biomarkers and verified in four public datasets. In addition, the expression characteristics of the identified miRNAs were further explored in tissue and serum exosomes samples.

Results
We identified a 3-miRNA signature including up-regulated miR-146a-5p, miR-24-3p and miR-93-5p for PC detection. Areas under the receiver operating characteristic curve of the 3-miRNA panel for the training, testing and external validation phase were 0.819, 0.831 and 0.814, respectively. The identified signature has a very stable diagnostic performance in the large cohorts of four public datasets. Compared with previously identified miRNA biomarkers, the 3-miRNA signature in this study has superior performance in diagnosing PC. What’s more, the expression level of miR-93-5p was also elevated in exosomes from PC samples. However, in PC tissues, none of the three miRNAs showed significantly dysregulated expression.

Conclusions
We established a three-miRNA panel (miR-146a-5p, miR-24-3p and miR-93-5p) in peripheral serum which could act as a non-invasive biomarker helping diagnosing PC.
Chemical synthesis of peptidoglycan mimetic–disaccharide-tetrapeptide conjugate and its hydrolysis by bacteriophage T5, RB43 and RB49 L-alanyl-D-glutamate peptidases
Authors: Azev Viatcheslav , Chulin Alexey , Molchanov Maxim , Prokhorov Dmitry , Mikoulinskaia Galina , Uversky Vladimir N. , Kutyshenko Viktor 
Published: May 2021

Background
Endolysins of a number of bacteriophages, including coliphages T5, RB43, and RB49, target the peptidoglycans of the bacterial cell wall. The backbone of these bacterial peptidoglycans consist of alternating N-acetylglucosamine and N-acetylmuramic acid residues that is further “reinforced” by the peptide subunits. Because of the mesh-like structure and insolubility of peptidoglycans, the processes of the peptidoglycan binding and hydrolysis by enzymes cannot be studied by spectral methods. To overcome these issues we synthesized and analyzed here one of the simplest water soluble peptidoglycan mimetics.

Methods
A compound has been synthesized that mimics the peptidoglycan fragment of the bacterial cell wall, N-acetylglucosaminyl-β(1-4)-N-acetylmuramoyl-l-alanyl-γ-d-glutamyl-l-alanyl-d-alanine. NMR was used to study the degradation of this peptidoglycan mimetic by lytic l-alanoyl-d-glutamate peptidases of colibacteriophages T5, RB43, and RB49 (EndoT5, EndoRB43, and EndoRB49, respectively).

Results
The resulting glycopeptide mimetic was shown to interact with the studied enzymes. Its hydrolysis occurred through the bond between l-Ala and d-Glu. This artificial substrate mimetic was hydrolyzed by enzymes at different rates, which decreased outside the pH optimum. The EndoT5 demonstrated the lowest hydrolysis rate, whereas the EndoRB49-driven hydrolysis was the fastest one, and EndoRB43 displayed an intermediate potency. These observations are consistent with the hypothesis that EndoRB49 is characterized by the lowest selectivity, and hence the potentially broader spectrum of the peptidoglycan types subjected to hydrolysis, which was put forward in the previous study. We also show that to hydrolyze this glycopeptide mimetic, enzymes approach the glycopeptide near the methyl groups of all three alanines.
Bioinspired Omniphobic Microchamber Structure
Authors: Kang Seong Min , Kim Hyunjung , Choi Ji Seong , An Joon Hyung 
Published: May 2021

AbstractIn this study, a novel cylindrical, mushroom‐shaped architecture array is proposed to achieve containable microchamber structures with stable omniphobic properties. By implementing a simple yet robust lithography method, a unique geometry of a double‐tip shape with high structural fidelity is fabricated. Such cylindrical re‐entrant structures are found to have omniphobic properties without surface chemical treatments. A microchamber morphology based on the formation of a Norland optical adhesive polymer roof on the surfaces of the donut‐shaped tip structures with micro‐dewetting phenomena is also demonstrated. Finally, SiO2 nanoparticles with an average size of 1.5 µm are successfully stored in the microchamber and protected with the polymer roof. This is expected to provide innovative inspiration for various application areas.