bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risks of using pre-event time scale and ordinal scale measurements in COVID-19 clinical trials
Authors: Yashchenko M.V. 
Published: December 2021

BACKGROUND. The article shows the results of literature search and analysis of endpoints of interventional clinical trials of phase III-IV of the treatment of hospitalized patients with coronavirus disease (COVID-19) and of its prevention.
MATERIALS AND METHODS. Among 102 trials found, ordinal scales were used in 60 trials, time-to-event outcome measures were used in 54 trials, both scales – in 49 trials. Time-to-event endpoints were related to hospitalization/intensive care unit term, discontinuation of oxygen therapy, and clinical improvement standardized on ordinal scales. At the same time, the early discontinuation of oxygen therapy and the early discharge create risks to the biometric measurement.
RESULTS AND DISCUSSION. Statistical calculations showed the association of the number of new COVID-19 hospital admissions per day with the percentage of free beds, but not only with the number of new coronavirus infection cases in general, the number of deaths and the number of people recovering from COVID-19 per day in different regions of Ukraine. These results may indicate that resource-dependence and organizational aspects affect the hospitalization of patients with COVID-19.
CONCLUSIONS. Therefore, to ensure that the discharge or discontinuation of oxygen therapy was due solely to a positive clinical outcome, data on changes of number of beds, access to oxygen supplies as well as data relevant to determination of the desired clinical outcome (body temperature, oxygen saturation, severity of symptoms, etc.) should be collected. It is recommended to collect biomarker data after discharge, if possible.
Validation of Modification of Volumetric Methode of Determination of Sn (Tin) Concentration on Tin Concentrates
Authors: Gunawan Onek 
Published: December 2021

The analysis techniques for determining the concentration of Stanum (Sn) in Tin Concentrate has been developing since the 19th century. Various methods and analysis techniques are to find the most effective and efficient method enabling to achieve optimal results. In this study, a modification of the classic volumetric method that has been used includes modifications to the use of materials and tools in the analysis. In this study, validation and verification of the modified method was also carried out by determining the value of the parameters of Precision, Accuracy, Method of Detection Limit (MDL) and the Ruggedness and Robustness of the method and comparing the acceptability value based on the existing provisions. on the EURACHEM guide. After performing 25 tests using the NCS DC 35002 Certified Reference Material, it was revealed the value of the parameters for the Precision/Relative Standard Deviation (RSD) to be 0.21% (<0.5 CV Horwitz), the accuracy value is 99.9% with bias 0.06%, the MDL values for Minimum Detection Limit (MDL) and Limit of Quantification (LOQ) are 0.4% and 1.32%, respectively. The value of the ruggedness and robustness of the method was carried out by testing at different times and by different analysts and obtained RSD 0.22% (<2/3 CV Horwitz). From the values of the parameters obtained, it can be concluded that the modification of this method fulfills the acceptance value required by EURACHEM.
Blue economy: The past and present from the world and future directions for Thailand
Authors: Koondee Phongsathon , Sharafuddin Mohammed Ali , Madhavan Meena 
Published: December 2021

This commentary article aims to summarize the past and present research of the blue economy from developing and developed nations and anticipates future research directions in the domain of blue economy policy research for Thailand. The importance of environmental protection, economic distribution, and social equality in the past were discussed and the present research shifted to addressing the complexity and defining the all-inclusive blue economy and all-inclusive participation, multiple stakeholder involvement and inter-regional cooperation, and global partnerships for knowledge and technology exchange. New blue economy sectors, such as ‘bioprospecting’, are also emerging in the present. However, the core concepts, such as defining ‘Blue Economy’, ‘Overfishing’, and ‘sustainable growth’, are still under debate. There is a perceptual disagreement among stakeholders in developing countries. Future directions in this research domain are also presented. This study concludes that future blue economy policies, plans, and implementation related research on blue economy must take account of environmental regulations and all-inclusive economic developmental plans that are measurable in terms of economic, environmental, and socio-cultural sustainability.
Impacto del Blockchain en la Contabilidad y Auditoría
Authors: Albanese Diana , Argañaraz Agustín , Daima Laura , López María de los Angeles , Mazzuchelli Agostina 
Published: December 2021

La disrupción de blockchain promete una mejora en el intercambio de datos eliminando intermediarios. La disponibilidad de la información para todos los intervinientes, la participación consensuada y en cadena, aseguran confiabilidad e inalterabilidad. Se espera que blockchain introduzca avances significativos en los sistemas de información contable y mejore la calidad de la información para los inversores. Al trabajar con una base de datos distribuida e incorruptible ahorra tiempo y costos de auditoria pero presenta un verdadero desafío en los paradigmas de evaluación de riesgos y controles. El trabajo consiste en un ensayo recopilando información sobre el funcionamiento del blockchain, y sus avances para la contabilidad y auditoría, identificando aspectos que requieren mayor desarrollo.
Kemampuan Koneksi Matematis Siswa SMA Berdasarkan Kecemasan Matematika
Authors: Astuti Juwita , Caswita Caswita 
Published: December 2021

One of mathematical abilities which is concepted by NTCM must be mastered by a student is mathematical connections. Some Study’s results showed that mathematics anxiety can influence students' mathematical abilities, including mathematical connections abilities. The study intends to know about mathematical connection’s ability that will be reviewed from high school students,s mathematics anxiety in solving problem related to material sequences and series. The samples in this study were 36 students of class XI IPA 2 at SMA N 1 Sekampung in East Lampung in academic year 2020/2021. Qualitative approach with descriptive method is used in this study. The tehnicque in collecting the data in this study by providing students math anxiety quessionair and tests to see the abilities of mathematical connections. There were 8 students indicated high math anxiety, 19 students indicated moderate math anxiety and 9 students indicated low math anxiety. The analysis was focused on the students who are chosen as the subject from each category. The conclusion is that student indicated high mathematics anxiety was able to achieve the ability to connect mathematical topics, connect mathematical topics to other sciences, while students with moderate and low mathematics anxiety can only achieve mathematics connection ability in indicator of connection in and between mathematical concepts. There is an anomaly in this study, which is due to high mathematics anxiety student get mathematical connection ability tend to be better. Keywords : Mathematical connection, mathematics anxiety, sequence
MİLLİ EĞİTİM MÜZİK DERSİNDE TÜRK MÜZİĞİ ENSTRÜMANLARI KULLANIMINA YÖNELİK ÖĞRETMEN GÖRÜŞLERİNİN İNCELENMESİ
Authors: ADAR Çağhan 
Published: December 2021

Hayatımızın her döneminde yer alan müzik toplumlara ve bölgelere göre şekillenmektedir. Doğduğumuz andan itibaren hayatımıza giren müzik, eğitim ile birlikte farklı bir yön almaktadır. Aldığımız eğitim ve çevresel faktörler ile birlikte müzikal tercihlerimiz şekillenmeye başlamaktadır. İlkokul ile başlayan genel müzik eğitimimiz lise sonuna kadar devam eder. Sonrasında ise lisans düzeyinde profesyonel müzik eğitimi başlamaktadır. Osmanlı döneminde haremde ve Enderun’da yapılan müzik eğitimi Cumhuriyetin ilanı ile Musiki Muallim Mektebi ile devam etmiş ve açılan yeni kurumlar ile günümüzde de devam etmektedir. Özellikle Türk müziği konservatuvarı mezunu öğrencilerin müzik öğretmeni olması ile birlikte, derslerde Türk müziği enstrümanlarının çalınma oranında artış görülmeye başlanmıştır.
Çalışmamızda, ilkokuldan başlayıp lise son sınıfına kadar verilen müzik derslerinde ki Türk müziği enstrümanlarının kullanılabilirliğinin araştırılması amaçlanmıştır. Çalışmada veri toplamak için anket formu hazırlanmış ve ulaşılabilen müzik öğretmenlerine uygulanmıştır ve veriler elde edilerek yorumlanmıştır. Çalışmanın alana katkı sağlayacağı ve Milli Eğitim’de müzik derslerinde Türk müziği enstrümanı kullanımına yönelik algıyı artıracağı düşünülmektedir.
OSMANLI’DA KADIN VE SPOR (OSMANLI KADIN BASINI IŞIĞINDA)
Authors: AKIN ZORBA Hatice 
Published: December 2021

Osmanlı Devleti’nde uzun bir sürece yayılmış olan modernleşme hareketi Tanzimat’ın ilanı ile hız kazanarak askeri, hukuki, idari, eğitim gibi pek çok alana sirayet etmiştir. Bu gelişim kadınların hayatını da etkilemiş evlilik, miras hukuku, eğitim gibi çeşitli alanlarda sahip oldukları haklar olumlu yönde değiştirilmiştir. Yaşanan toplumsal değişime ve Avrupa’daki gelişmelere paralel olarak kadının toplumdaki konumu, hakları, eğitimi gibi konular Tanzimat aydınları tarafından edebi eserlerde ve dönemin gazetelerinde kaleme aldıkları makalelerle eleştirilmeye ve sorgulanmaya başlamıştır. Osmanlı kadınlarının durumunun bu şekilde gündeme getirilmesi ve basında kadınların yer bulması, kadınlara yönelik dergilerin çıkarılmasının önünü açmıştır. İlk defa 1868’de başlayan kadın basını hızlı bir gelişme seyretmiş, kadın gazetelerinin sayısı özellikle II. Meşrutiyet’ten giderek artmıştır.
Son derece zengin bir içeriğe sahip olan kadın gazeteleri, hak ve özgürlük mücadelesinde kadınların görünürlüğünü arttırırken, kadınların kültürel ve kişisel gelişimlerine de hizmet etmiştir. Sosyal hayat, eğitim, hukuk, iş hayatı gibi çeşitli alanlarda hak arayışının yanı sıra aile, evlilik, kadın-erkek ilişkileri, çocuk eğitimi, giyim, spor, moda, ev idaresi gibi birçok farklı konuda yazılara, Avrupa’daki hemcinslerinin hayatına, iç ve dış gelişmelere dair haberlere yer verilmiştir.
Bu çalışmada Osmanlı kadın basınında yer alan spora dair yazılar incelenerek, kadınların sporla ilişkisi, spor algısı, farkındalığı, sporun hangi yönlerden ele alındığı ortaya konulmaya çalışılmıştır. Konu değerlendirilirken yayım hayatına Osmanlı Devleti zamanında başlayan dergi ve gazeteler dikkate alınmıştır. Osmanlı kadın basınında yer alan yazıların tespiti için Kadın Eserleri Kütüphanesi ve Bilgi Merkezi Vakfı tarafından yayımlanan İstanbul Kütüphanelerindeki Eski Harfli Türkçe Kadın Dergileri Bibliyografyası (1869-1927)’ndan yararlanılmıştır. Ayrıca Osmanlı basınında kadın ve spora dair kaleme alınan bazı yazılara da yer verilmiştir.
Análise das infecções causadas por bactérias Gram negativas produtoras de carbapenemases em um hospital dos Campos Gerais
Authors: Stüker Caroline Andressa Schiestl , Bail Larissa , Ito Carmen Antônia Sanches , Montes Elisangela Gueiber 
Published: December 2021

Objetivo: Determinar o perfil e a prevalência das infecções hospitalares causadas por bactérias Gram negativas resistentes aos carbapenêmicos relacionadas à saúde. Metodologia: Este estudo foi transversal descritivo retrospectivo (Yin, 2015) e analisou o perfil das infecções em um único hospital público, por meio de coleta de dados nos prontuários eletrônicos. A coleta incluiu dados demográficos e achados clínicos e laboratoriais relacionados a infecção. Resultados: Foram analisadas 193 aquisições de bactérias Gram negativas, dos quais 25 foram por microrganismos resistentes aos carbapenêmicos. Destes, a espécie mais comum detectada foi a Klebsiella pneumoniae (56%, 14/25). Quanto as infecções, o setor hospitalar predominante foi a unidade de terapia intensiva (56%, 14/25), a maioria relacionado a pneumonia associada a ventilação mecânica (40%, 10/25) e em pacientes submetidos a algum procedimento invasivo (72%, 18/25). Cerca de 50% dos pacientes possuía alguma condição de saúde adjacente. O tratamento antimicrobianos anterior ao diagnóstico foi identificado em 72% (19/25) dos pacientes, com predomínio de betalactâmicos (85,7%, 12/19) e após o diagnóstico, a maioria utilizou monoterapia (72%, 19/25). O impacto da infecção foi que 68% (17/25) internados em unidade de terapia intensiva, 40% (10/25) evoluíram para óbito e 60% (15/25) receberam alta hospitalar. Conclusão: Os resultados estão de acordo com a literatura atual e destacam a importância da prevenção no combate a propagação destes microrganismos em ambientes hospitalares.
The content of heavy metals in the leaves of Tilia cordata Mill. and in the soils of urban ecosystems of Cherkasy city
Authors: Korneliuk N. , Koniakin S. , Hrodzynska A. 
Published: December 2021

The growth of technogenic impact on urbo-landscapes is accompanied by man-made contamination of the environment. Among the most toxic and widespread pollutants of the urban ecosystems an important place belongs to heavy metals. The soil is the main source of accumulation of heavy metals and its uptake by the biota objects, including plants. Elevated concentrations of heavy metals in plant products, in turn, lead to intoxication of people and animals. Toxicity of heavy metals due to their biological activity and availability, resistance of their compounds in the environment, the possibility of small concentrations cause significant negative effects. For the city of Cherkasy the main polluters of the environment with heavy metals are the subsidiary of Cherkasy thermal power (accounting for 75% of the total amount of heavy metals emitted, and contribution of thermal power for emission of Pb, Cu and Zn reach 85%) and automobile transport. It should be noted that the city of Cherkasy (population 285.000 people) is an important economic center of Ukraine, with well-developed chemical and automobile industries. With atomic absorption spectroscopy the content of heavy metals (Cu, Zn, Pb and Cd) in the leaves of bio-indicator species Tilia cordata Mill. and soils from 24 localities of the city of Cherkassy was examined. The general content of the leaf biomass and soils from different localities of the degree of technogenic pollution of heavy metals are arranged in a sequence Zn > Cu > Pb > Cd. In the city the content Pb and Cd in soils were below the MPK (maximum permissible concentration). Apparently, the content of copper and zinc soils, first of all, caused by pollution of chemical plants emissions, lead, due to industrial and transport factors and cadmium, of the distances to highways. The data obtained suggest that small-leaved linden (T. cordata Mill.) is as a representative species for bio-indication of heavy metals pollution in urban territories
The diversity of bean nodule bacteria in Ukrainian agrocenoses
Authors: Krutylo D. , Nadkernychna O. , Sherstoboieva О. 
Published: December 2021

The aim of our work was to study the diversity of beans nodule bacteria in the natural populations of rhizobia and spend their serological and genetic typing. Beans rhizobia were isolated from bean nodules which were grown in soil samples selected in different regions of Ukraine. Morphological, cultural and physiological properties of rhizobia were studied using standard methods. The diversity of beans nodule bacteria was assessed using a serological method. The restriction analysis of the intergenic region of the ribosomal cluster (ITS) was carried out with the use of restriction endonucleases MspI, HaeIII, NdeII. Fifty strains of beans nodule bacteria were isolated from soils of different regions of Ukraine. Biological diversity of these strains was studied. All the culture of nodule bacteria enters into a symbiotic relationship with the common beans and forms active nodules on the plant roots. These strains were identified as Rhizobium phaseoli. It is established that new strains of R. phaseoli differ in antibiotics sensitivity, serological and genetic properties. On antigenic com- position investigated nodule bacteria were combined into different serological groups. The beans rhizobia, isolated from agrocenosis of Chernihіv region was the most serologically diverse. PCR-RFLP of the ITS- region showed significant genetic polymorphism of common beans microsymbionts, isolated from local populations of rhizobia. On the basis of the restriction profiles of the 16S-23S rDNA these strains were first divided into different IТS-types. It is established that division the strains on ITS-types (NdeII and HaeIII) corresponds to their division into different serological groups.
Updating legislation in the field of intellectual property in the conditions of recodification: directions, problems, prospects
Authors: Kodynets Anatolii 
Published: December 2021

Keywords: systematization; recodification; legislation; intellectual property; collision;protection of rights; the results of intellectual, creative activity
Implementation ofan innovative model in Ukraine is not possible without the creation of a modern systemof regulatory relations in the field of protection of intellectual property that would ensureprotection of human subjects of creative work (authors, artists, and inventors), guaranteeingobservance of their rights, and protection against possible violations.The first steps in improving a legal mechanism for the use of results of intellectualand creative activities are laid in adopted in 2003 by the Civil Code of Ukraine, which notonly greatly expanded the scope of intellectual property rights, but also significantly enrichedits substance. In the Civil Code of Ukraine relations in the field of intellectualproperty were first fixed in a separate structural part (book 4 «Intellectual PropertyRights»), which indicates their importance to private law.Further improvement of the normative array in the field of protection of the results ofcreative activity should provide for the specification of the provisions of the Civil Code ofUkraine at the level of laws and by-laws, aimed at the formation of reliable legal mechanismsfor the implementation and protection of intellectual property rights. However,only now changes have been made to special laws in the field of intellectual property. In2014, Ukraine signed an Association Agreement with the EU. It became necessary tobring the existing regulatory material not only to the Civil Code of Ukraine, but also tocomply with the approaches defined in the provisions of the Association Agreement,Chapter 9 of which contains the requirements and standards for the protection of intellectualproperty rights.The article examines the problems of updating and systematizing the legislation ofUkraine in the field of legal protection of the results of intellectual, creative activity,analyses the collisions and shortcomings of certain norms governing relations in the fieldof intellectual activity. The legal basis for the regulation of the protection of differenttypes of intellectual property objects is investigated, the ways of their improvement aredetailed, the steps taken in this direction in Ukraine are described. Within the frameworkof the research subject, the shortcomings of special legislation, as well as the normsof the Civil Code of Ukraine, contradictions between various legislative acts in the field ofintellectual property are noted and ways of their resolution are proposed.
Protection of intellectual property rights in the field of biotechnology
Authors: Fedotova Hanna , Fyl Svitlana 
Published: December 2021

Keywords: intellectual property rights, biotechnologies, patenting, legal protection,legislation
Current trends of globalization and the process of European integrationof Ukraine necessitate the creation of an effective mechanism of legal regulationof intellectual property rights in the field of biotechnology, due to the constitutionalprovisions according to which human life and health are the highest value inthe state. The purpose of the study was to determine the legal regulation of protection
of intellectual property rights in the field of biotechnology. Empirical and theoreticalmethods of scientific cognition are used for comprehensive consideration of the topicof the article. It has been found that modern biotechnological advances require inventorsnot only to secure monopoly rights to use them, but also to comply with the moraland ethical criteria for the perception of inventions created by genetic engineeringand living matter. It is determined that the legal system of intellectual property protectionin the field of biotechnology is based on the provisions of the Constitution ofUkraine, the Civil Code of Ukraine, regulations in the field of health and agriculture,international treaties and special legislation in the field of intellectual property. It isestablished that the system of legal protection of biotechnological inventions consistsof the acquisition of intellectual property rights to these inventions (establishment ofthe object of patenting and compliance with patentability, state registration of inventions)and the use and disposal of intellectual property rights to such inventions. Alegislative support of legal protection of biotechnological inventions is seen in furtherempirical research and theoretical and methodological substantiation in order to determinethe legal mechanisms of their practical implementation.