bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased selenium concentration in the synthesis of CdSe magic‐sized quantum dots affects how the brain responds to oxidative stress
Authors: Vilela Danielle Diniz , Justino Allisson Benatti , Caixeta Douglas Carvalho , de Souza Adriele Vieira , Teixeira Renata Roland , Franco Rodrigo Rodrigues , Saraiva André Lopes , Fonseca Belchiolina Beatriz , Dantas Noelio Oliveira , Silva Anielle Christine Almeida , Espindola Foued Salmen 
Published: December 2021

AbstractCdSe magic‐sized quantum dots (MSQDs) have been widely used as fluorescent probes in biological systems due to their excellent optical properties with a broader fluorescence spectrum and stable luminescence in biological media. However, they can be cytotoxic and alter the redox balance depending on the amounts of Cd2+ adsorbed on their surface. Thus, the present study aimed to evaluate whether increases in selenium concentration in the synthesis of CdSe‐MSQDs decrease the oxidative stress caused by Cd2+‐based quantum dots. CdSe‐MSQDs synthesized with different concentrations of selenium were investigated against oxidative stress in the brain of chicken embryos by examining total antioxidant capacity, lipid peroxidation, thiol, and glutathione contents, as well as the activities of glutathione peroxidase, superoxide dismutase (SOD), catalase (CAT), and glutathione reductase. In addition, the vascularization of the chorioallantoic membrane (CAM) analysis was performed. Higher selenium concentrations alter the surface defect levels (decrease free Cd2+) and controlled the oxidative effects of CdSe‐MSQDs by reducing the lipid peroxidation, restoring the glutathione defense system and the antioxidant enzymes SOD and CAT, and maintaining the vascular density of the CAM. The current findings reinforce the study of the effects of the presence of Cd2+ ions on the surface of quantum dots, changing toxicity, and aiming interesting strategies of nanomaterials in biological systems.
Cultural appropriation, appreciation, and adaption: A rejoinder to “Effects of a Rite of Passage Ceremony on Veterans' Well‐Being”
Authors: Meade Nicola A. , Branco Susan F. , Burt Isaac , White Roni K. , Hanks Alaina 
Published: December 2021

AbstractThis rejoinder critically examines Greenleaf, Roessger, Williams, and Motsenbocker's article in the Journal of Counseling & Development (JCD) entitled “Effects of a Rite of Passage Ceremony on Veterans' Well‐Being” using the concepts cultural appropriation, appreciation, and adaption, combined with the Multicultural and Social Justice Counseling Competencies (MSJCCs). We will introduce these terms and connect them to examples related to Native American history, while providing an analysis of the article's approach to Native American culture. Concluding the rejoinder are suggestions to meet multicultural competencies, including pragmatic ways in which counseling practice and research can improve and a checklist applicable for practitioners and scholars.
Internet use, depression, and cognitive outcomes among Chinese adolescents
Authors: Zhou Muzhi , Ding Xuejie 
Published: December 2021

AbstractThis study provides new evidence on how the growingly significant digital life shapes Chinese adolescents' cognitive and mental health outcomes based on their gender, parental education, and geographical location. Using the China Education Panel Survey, a nationally representative survey following 12–15‐year‐old students in 2013 and 2014, and individual fixed‐effect models, we find that more time spent on the Internet is associated with higher self‐reported depression scores. This negative impact on mental health is more substantial for girls, those with less‐educated parents, and those living outside the city center. The link between Internet use and cognitive development is almost null. Time spent online negatively affects Chinese young adolescents' subjective well‐being but has little impact on their cognitive development. The link between Internet use time and subjective well‐being also depends on gender, parental education, and the geographical location of those adolescents. The heterogeneous impacts of Internet use time offer crucial new evidence to the multiple dimensions of the digital divide among adolescents in China.
Physiological and kinetic evaluation of ampicillin oxidation as unique electron source by a denitrifying sludge
Authors: Yeny Banda , Anne‐Claire Texier , Flor de María Cuervo‐López 
Published: December 2021

AbstractBACKGROUNDDenitrification allows the simultaneous oxidation of recalcitrant compounds and the reduction of nitrate. Scarce information on consumption and oxidation of ampicillin (AMP) as sole electron source is found in the literature. The physiological and kinetic ability of a denitrifying sludge without previous exposure to antibiotics for oxidizing several AMP concentrations was evaluated.RESULTSComplete denitrification was accomplished in batch reference assays with acetate (20–100 mg C L−1) and nitrate (C/N 1.1) within 4 h of culture, resulting in yields of HCO3− (YHCO3−) and N2 (YN2) of 0.89–1.0 mg C or N produced mg−1 C or N consumed, respectively. Assays amended with different concentrations of AMP (5–100 mg C L−1) as unique electron source at stoichiometric C/N ratio (0.86) showed that within 8–12 h of culture the antibiotic was totally consumed and oxidized to HCO3− and CO2 (YHCO3− between 0.27 and 0.67 and YCO2 between 0.35 and 0.54 mg C produced mg−1 C consumed), while nitrate was mostly reduced to N2 (YN2 = 0.77–1.0 mg N produced mg−1 N consumed). At AMP concentrations higher than 20 mg C L−1, N2O and carbon intermediates production was detected. Decreases of 20–90% in denitrifying specific rates were determined regarding the denitrifying reference. After exposure to the antibiotic, the sludge was able to recover its denitrifying activity in the absence of AMP with no N2O accumulation, whereas only 39% of the denitrification rates were recuperated.CONCLUSIONIt was clearly evidenced that AMP was used as electron donor for conducting denitrification; however, the denitrifying process occurred at lower specific rates. © 2021 Society of Chemical Industry (SCI).
Graph colorings with restricted bicolored subgraphs: II. The graph coloring game
Authors: Bradshaw Peter 
Published: December 2021

AbstractWe consider the graph coloring game, a game in which two players take turns properly coloring the vertices of a graph, with one player attempting to complete a proper coloring, and the other player attempting to prevent a proper coloring. We show that if a graph has a proper coloring in which the game coloring number of each bicolored subgraph is bounded, then the game chromatic number of is bounded. As a corollary to this result, we show that for two graphs and with bounded game coloring number, the Cartesian product has bounded game chromatic number, answering a question of X. Zhu. We also obtain an upper bound on the game chromatic number of the strong product of two graphs.
Magnetic Resonance Imaging During a Pandemic: Recommendations by the ISMRM Safety Committee
Authors: Collins Jeremy D. , Rowley Howard , Leiner Tim , Reeder Scott , Hood Maureen , Dekkers Ilona , Tha Khin , Gulani Vikas , Kopanoglu Emre ,   for the ISMRM MR Safety Committee
Published: December 2021

The COVID‐19 pandemic highlighted the challenges delivering face‐to‐face patient care across healthcare systems. In particular the COVID‐19 pandemic challenged the imaging community to provide timely access to essential diagnostic imaging modalities while ensuring appropriate safeguards were in place for both patients and personnel. With increasing vaccine availability and greater prevalence of vaccination in communities worldwide we are finally emerging on the other side of the COVID‐19 pandemic. As we learned from our institutional and healthcare system responses to the pandemic, maintaining timely access to MR imaging is essential. Radiologists and other imaging providers partnered with their referring providers to ensure that timely access to advanced MR imaging was maintained. On behalf of the International Magnetic Resonance in Medicine (ISMRM) Safety Committee, this white paper is intended to serve as a guide for radiology departments, imaging centers, and other imaging specialists who perform MR imaging to refer to as we prepare for the next pandemic. Lessons learned including strategies to triage and prioritize MR imaging research during a pandemic are discussed.Level of Evidence5Technical EfficacyStage 5
Temperature extremes and circulation types in the Czech Republic, 1961–2020
Authors: Zahradníček Pavel , Brázdil Rudolf , Řehoř Jan , Lhotka Ondřej , Dobrovolný Petr , Štěpánek Petr , Trnka Miroslav 
Published: December 2021

AbstractThis paper presents the characteristics of extreme temperatures in the Czech Republic, as calculated from homogenized series of daily maximum (TMAX) and daily minimum (TMIN) temperatures recorded by 133 climatological stations throughout the territory in the 1961–2020 period. In general, statistically significant increasing linear trends were recognized in series of absolute TMAX, absolute TMIN, numbers of summer days, tropical days, days with tropical nights, heat‐wave, and warm‐anomaly days. Significant decreasing linear trends appeared in series of numbers of frost days, ice days, cold‐wave, and cold‐anomaly days. Objective classification of circulation types demonstrated the importance of anticyclonic types (especially those with warm airflow from the southern quadrant) and an unclassified type in the development of summer hot extremes, while winter cold extremes were linked to cold (north‐)easterly advection. Significant changes in the frequency of certain circulation types emerged, as well as an increasing number of anticyclonic types conducive to hot extremes, a trend that contributed to their more frequent occurrence in recent decades. Existing trends in temperatures were complemented by spatiotemporal analysis of extreme temperatures, the characteristics of extremes and the circulation types in the two “normal” periods of 1961–1990 and 1991–2020. These exhibited significant differences in means and variances. The results obtained are also discussed in a broader context.
Eurasian Holocene climate trends in transient coupled climate simulations and stable oxygen isotope records
Authors: DANEK CHRISTOPHER , GIERZ PAUL , KOSTROVA SVETLANA S. , MEISTER PHILIP , MEYER HANNO , WERNER MARTIN 
Published: December 2021

AbstractTransient simulations of the global fully coupled climate model COSMOS under realistic varying orbital and greenhouse gas forcings are systematically compared to diatom oxygen isotope () records from Russian lakes with focus on Eurasian Holocene climate trends. The measured decrease and other temperature proxies are interpreted as large‐scale cooling throughout the Holocene while the model simulations are biased too warm, likely through missing radiative forcings. This large‐scale warm bias also dictates the modeled . Hence, at locations where the signs of model and proxy temperature/precipitation trends agree, measured and modeled trends show notable accordance. An increased temporal variability of modeled is linked to persistent atmospheric circulation patterns. Applying the transient forcings in an accelerated way (every 10th year only) yields a similar, yet weaker or delayed model response, especially in the ocean.
Genetic variants in SLC22A1 are related to serum lipid levels in Mexican women
Authors: Cahua‐Pablo José Ángel , Gómez‐Zamudio Jaime Héctor , Reséndiz‐Abarca Carlos Alberto , Tello‐Flores Vianet Argelia , Eulogio‐Metodio Yesica , Ramírez‐Vargas Marco Antonio , Cruz Miguel , del Carmen Alarcón‐Romero Luz , Matia‐García Inés , Marino‐Ortega Linda Anahí , Zubillaga‐Guerrero Ma. Isabel , Flores‐Alfaro Eugenia 
Published: December 2021

AbstractDyslipidemia is the main risk factor for coronary artery disease and is characterized by alterations in concentrations of lipids, including low‐density lipoprotein cholesterol (LDL‐c), high‐density lipoprotein cholesterol (HDL‐c), and triacylglycerols. The participation of several genes in the development of dyslipidemia has been evidenced. Genetic variants in SLC22A1 have been associated with elevated cholesterol and LDL‐c levels. The aim of this study was to evaluate the association between single‐nucleotide polymorphisms (SNPs) in the SLC22A1 gene with atherogenic risk lipid levels in Mexican women. Anthropometric and biochemical measurements were performed, and four SNPs in SLC22A1 were genotyped by real‐time polymerase chain reaction. The Hardy–Weinberg equilibrium was verified, and haplotype frequencies were calculated. We found significant differences between the allele frequencies of the SNPs analyzed with those reported in Mexico and in the world, which could be due to differences in the historical admixture of the women studied. Generalized linear models were evaluated to determine the association between genotypes and haplotypes with lipids levels. We identified a significant increase in total cholesterol and LDL‐c levels in women who were carriers of the GA and AG genotypes of the polymorphisms rs628031 and rs594709, respectively, significant effect that is also shown in a dominant inheritance model. Interestingly, we identified an important relationship of the AGC‐GAT haplotype with the elevation in LDL‐c levels and AGA‐GAT haplotype with the elevation in HDL‐c levels. On the other hand, we found a strong linkage disequilibrium between the polymorphisms studied. Our results show that variants in the SLC22A1 gene influence serum levels of atherogenic risk lipids, suggesting that these variants probably affect the function of organic cation transporter‐1 and therefore, on the regulation of lipid metabolism.
Assessment of styrene‐divinylbenzene polymer (PPL) solid‐phase extraction and non‐targeted tandem mass spectrometry for the analysis of xenobiotics in seawater
Authors: Cancelada Lucia , Torres Ralph R. , Garrafa Luna James , Dorrestein Pieter C. , Aluwihare Lihini I. , Prather Kimberly A. , Petras Daniel 
Published: December 2021

AbstractAnthropogenic imprints have become a fundamental part of most ecosystems. Our chemical footprint is often detected using targeted approaches, whereas xenobiotics are embedded within the large pool of dissolved metabolites, altered by biotic and abiotic mechanisms. Thus, it is necessary to simultaneously study anthropogenic signals entwined with the variety of organic signatures that exist in aquatic environments. However, methods for non‐targeted analysis of natural metabolites are not always well suited for the analysis of pollutants. Here, we report the reassessment of styrene‐divinylbenzene polymer‐based Priority PolLutant (PPL) solid‐phase extraction (PPL‐SPE), which is typically used to extract marine dissolved organic matter (DOM) for biogeochemical studies, to analyze a set of xenobiotics commonly observed in coastal North Pacific seawater. After PPL extraction and analysis by nontargeted liquid chromatography tandem mass spectrometry (LC–MS/MS), we successfully detected 23 out of 25 selected pharmaceuticals, personal care products, biocides, perfluorocarbons, and polymer additives in a complex marine DOM sample using positive and negative electrospray ionization. We tested two pH conditions to mimic typical marine DOM extraction studies and found mean recovery rates of xenobiotics were approximately 10% higher in seawater pH (pH ~ 8) than in acidified samples (pH ~ 2) for both negative and positive modes, although overall, mean recovery rates were 10% lower in negative mode. Our results indicate that PPL‐SPE in combination with non‐targeted LC–MS/MS is capable of capturing the tested set of xenobiotics, thus allowing the repurposing of biogeochemical sampling strategies as well as existing DOM samples and MS data for the subsequent assessment of anthropogenic impacts in marine environments.
Lower Alpha‐Fetoprotein Threshold of 500 ng/mL for Liver Transplantation May Improve Posttransplant Outcomes in Patients With Hepatocellular Carcinoma
Authors: Goldman Max L. , Zhou Kali , Dodge Jennifer L. , Yao Francis , Mehta Neil 
Published: December 2021

Under current United Network for Organ Sharing (UNOS) policy, patients with hepatocellular carcinoma (HCC) and alpha‐fetoprotein (AFP) levels ≥1000 ng/mL are required to show a reduction in AFP level to <500 ng/mL before liver transplantation (LT). However, effects of AFP reduction on post‐LT HCC outcomes among patients with HCC with moderately elevated AFP levels between 100 and <1000 ng/mL are unclear. Adults in the UNOS registry who underwent LTs from January 2005 to September 2015 with initial AFP levels of 100 to 999 ng/mL at listing for Model for End‐Stage Liver Disease exceptions were included. Primary predictor was AFP level at LT, categorized as <100, 100 to 499, or ≥500 ng/mL, and patients with only 1 recorded pre‐LT AFP value (AFP 1‐value). Survival was compared using the Kaplan‐Meier curve method. Factors associated with post‐LT survival and HCC recurrence were assessed in a multivariable Cox regression model. Among 1766 included patients, 50.2% had AFP 1‐value, followed by 24.7%, 18.9%, and 6.2% with AFP levels <100, 100 to 499, and ≥500 ng/mL, respectively. The 5‐year post‐LT survival rate was lowest in the AFP ≥500 category, at 56.1%, compared with 72.7%, 70.4%, and 65.6% in the AFP <100, 100 to 499 ng/mL, and AFP 1‐value categories, respectively. In multivariable analysis, AFP ≥500 ng/mL at LT was associated with a greater risk of post‐LT death (hazard ratio [HR], 1.5; 95% confidence interval [CI], 1.1‐2.1) and HCC recurrence (HR, 1.9; 95% CI, 1.1‐3.1) when compared with the AFP <100 ng/mL category; other significant variables included donor risk index, age, race/ethnicity, Child‐Turcotte‐Pugh class, and tumor diameter. Among AFP levels ≥500 ng/mL at LT, 40.4% had AFP levels ≥1000, but no difference in post‐LT survival or recurrence was seen between those patients with AFP levels < or ≥1000 ng/mL. Mandating AFP <500 ng/mL at LT for all patients, not only for those with initial AFP levels ≥1000 ng/mL, may improve post‐LT outcomes and can be considered in future UNOS policy.
Augmented reality advertising via a mobile app
Authors: Sung Eunyoung (Christine) , Han Dai‐In Danny , Choi Yung Kyun 
Published: December 2021

AbstractAugmented reality (AR) mobile app advertising offers new opportunities for interactive consumer engagement to boost advertising effectiveness and elicit positive consumer responses. In this study, we investigate the role of escapism by analyzing its antecedents and consequences. We aim to shed light on how AR mobile app advertising can be used to enhance escapism experiences by considering two psychological mechanisms of mental imagery: narrative transportation (in response to ad storytelling) and spatial immersion. The consequences of escapism experiences include positive social media sharing, purchase intentions through brand attitudes, and new brand engagement via AR mobile app advertising. Prior brand preference does not affect the relationship between escapism and consumer responses after exposure to immersive AR advertising. Our findings have meaningful implications for how industry practitioners can enhance escapism in the context of AR mobile app advertising.
Patient engagement in the design of an intervention to prevent muscle loss in individuals with knee osteoarthritis and a body mass index (BMI) ≥ 35
Authors: Godziuk Kristine , Prado Carla M. , Forhan Mary 
Published: December 2021

AbstractObjectiveInterventions for knee osteoarthritis (OA) in adults with a large body size (defined as a body mass index [BMI] ≥ 35 kg/m2) often prioritise weight‐loss, which may overshadow specific benefits for physical function, metabolic health, and body composition. As part of the development of a future clinical study, we gathered perspectives from individuals living with knee OA and a large body size to inform the proposed intervention design and delivery.MethodsPurposive and voluntary sampling was used to engage individuals ≥40 years of age with self‐reported knee OA and a BMI ≥ 35 kg/m2. An anonymous electronic survey was distributed on social media between April 2020 and June 2020. Open‐ended questions addressed a proposed 12‐week multimodal intervention (involving targeted nutrition, resistance exercises, and self‐management support). An optional semi‐structured interview was offered upon completion, with interviews recorded and transcribed verbatim. Reflexive thematic analysis and interpretation guided by an acceptability framework was used to identify recommendations for the intervention design and delivery.ResultsTwenty individuals living across Canada completed the survey (100% female; 18 aged <65 years and 2 ≥ 65 years). Ten individuals completed the interview. From aggregate survey and interview data, three recommendations were generated: (1) the effectiveness of the intervention for health improvement (specifically mobility and pain) must be emphasised to avoid perceived weight‐loss expectations; (2) extend support beyond 12‐weeks and consider terminology free from weight‐bias to enhance acceptance; (3) include optional customisation of intervention delivery to reduce acceptability‐related burden.ConclusionThese female patient‐derived recommendations may improve perceived intervention acceptability, and thereby may enhance participant enrolment and retention in clinical trials.
Influence of foundation flexibility on the topology optimization of piled structures
Authors: Cavalcante Iago , Tavares Emanuel , Picelli Renato , Labaki Josué 
Published: December 2021

AbstractThis article investigates the influence of foundation and soil flexibility on the topology optimization of piled structures. The structure is modeled with classical finite elements, while the embedded pile group foundation and its interaction with the soil are modeled via the stiffness matrix method. Coupling between the structure and its foundation is obtained by establishing direct continuity and equilibrium conditions at their interface. Topology optimization of the discretized piled structure is performed through the Bi‐directional Evolutionary Structural Optimization (BESO) method for various boundary conditions. The objective function of the optimization problem is the minimization of the compliance of the piled structure under prescribed volume restriction. The results show that the flexibility of the soil and piles may have a significant effect on the optimal topology of the structure, as well as on the achievable optimization objective.
MyD88 in myofibroblasts regulates aerobic glycolysis‐driven hepatocarcinogenesis via ERK‐dependent PKM2 nuclear relocalization and activation
Authors: Yuan Qi , Zhang Jie , Liu Yu , Chen Haiqiang , Liu Haiyang , Wang Jinyan , Niu Meng , Hou Lingling , Wu Zhenlong , Chen Zhinan , Zhang Jinhua 
Published: December 2021

AbstractHepatic stellate cells (HSCs) and cancer‐associated fibroblasts (CAFs) play critical roles in liver fibrosis and hepatocellular carcinoma (HCC). MyD88 controls the expression of several key modifier genes in liver tumorigenesis; however, whether and how MyD88 in myofibroblasts contributes to the development of fibrosis‐associated liver cancer remains elusive. Here, we used an established hepatocarcinogenesis mouse model involving apparent liver fibrogenesis in which MyD88 was selectively depleted in myofibroblasts. Myofibroblast MyD88‐deficient (Fib‐MyD88 KO) mice developed significantly fewer and smaller liver tumor nodules. MyD88 deficiency in myofibroblasts attenuated liver fibrosis and aerobic glycolysis in hepatocellular carcinoma tissues. Mechanistically, MyD88 signaling in myofibroblasts increased the secretion of CCL20, which promoted aerobic glycolysis in cancer cells. This process was dependent on the CCR6 receptor and ERK/PKM2 signaling. Furthermore, liver tumor growth was greatly relieved when the mice were treated with a CCR6 inhibitor. Our data revealed a critical role for MyD88 in myofibroblasts in the promotion of hepatocellular carcinoma by affecting aerobic glycolysis in cancer cells and might provide a potential molecular therapeutic target for HCC. © 2021 The Pathological Society of Great Britain and Ireland.