bluuebunny/crossref_metadata_2025_split huggingface dataset:
Domestic and international migration intentions in response to environmental stress: A global cross-country analysis
Authors: Bekaert Els , Ruyssen Ilse , Salomone Sara 
Published: March 2021

AbstractIn light of increasing environmental stress and its likely implications for migration patterns, we conduct a cross-country individual-level analysis of the impact of self-reported exposure to environmental stress on people's migration intentions and their destination choice. We simultaneously model intentions to migrate domestically and internationally for 90 countries worldwide in 2010. We find that self-reported exposure to environmental stress increases the probability to intend to migrate both domestically and internationally in the coming year. In absolute terms, the largest impact is obtained for domestic migration, but controlling for the fact that this is the most common form of migration anyway, environmental stress particularly raises intraregional migration intentions. Overall, the effects on migration intentions to the different destinations are strongest in low- and middle-income countries in Africa and Latin America and the Caribbean, while in high-income countries, and in Europe particularly, environmental stress appears to spur only domestic migration intentions.
Gendered securitisation: Trump's and Putin's discursive politics of the COVID-19 pandemic
Authors: Kuteleva Anna , Clifford Sarah J. 
Published: March 2021

AbstractThis article presents a study of the discursive politics of the COVID-19 outbreak in the United States and Russia from its early onset to 30 April 2020. We examine how official securitisation discourses in the two countries draw on gendered constructions of national identity and discuss what linkages and potential implications they have for the state, its policy, and its society. Our analysis shows that both the US President Donald Trump and Russia's President Vladimir Putin instrumentalise hierarchical gendered identities to securitise COVID-19. They mobilise gendered narratives, imageries, and practices to affirm particular understandings of the threat and create a homogeneous national ‘we’, portraying themselves as its guardians.
KUMMER COVERINGS AND SPECIALISATION
Authors: Olsson Martin 
Published: March 2021

AbstractWe prove versions of various classical results on specialisation of fundamental groups in the context of log schemes in the sense of Fontaine and Illusie, generalising earlier results of Hoshi, Lepage and Orgogozo. The key technical result relates the category of finite Kummer étale covers of an fs log scheme over a complete Noetherian local ring to the Kummer étale coverings of its reduction.
AI for humanitarian action: Human rights and ethics
Authors: Pizzi Michael , Romanoff Mila , Engelhardt Tim 
Published: March 2021

AbstractArtificial intelligence (AI)-supported systems have transformative applications in the humanitarian sector but they also pose unique risks for human rights, even when used with the best intentions. Drawing from research and expert consultations conducted across the globe in recent years, this paper identifies key points of consensus on how humanitarian practitioners can ensure that AI augments – rather than undermines – human interests while being rights-respecting. Specifically, these consultations emphasized the necessity of an anchoring framework based on international human rights law as an essential baseline for ensuring that human interests are embedded in AI systems. Ethics, in addition, can play a complementary role in filling gaps and elevating standards above the minimum requirements of international human rights law. This paper summarizes the advantages of this framework, while also identifying specific tools and best practices that either already exist and can be adapted to the AI context, or that need to be created, in order to operationalize this human rights framework. As the COVID crisis has laid bare, AI will increasingly shape the global response to the world's toughest problems, especially in the development and humanitarian sector. To ensure that AI tools enable human progress and contribute to achieving the Sustainable Development Goals, humanitarian actors need to be proactive and inclusive in developing tools, policies and accountability mechanisms that protect human rights.
Spontaneously coherent orbital coupling of counterrotating exciton polaritons in annular perovskite microcavities
Authors: Wang Jun , Xu Huawen , Su Rui , Peng Yutian , Wu Jinqi , Liew Timothy C. H. , Xiong Qihua 
Published: March 2021

AbstractExciton-polariton condensation is regarded as a spontaneous macroscopic quantum phenomenon with phase ordering and collective coherence. By engineering artificial annular potential landscapes in halide perovskite semiconductor microcavities, we experimentally and theoretically demonstrate the room-temperature spontaneous formation of a coherent superposition of exciton-polariton orbital states with symmetric petal-shaped patterns in real space, resulting from symmetry breaking due to the anisotropic effective potential of the birefringent perovskite crystals. The lobe numbers of such petal-shaped polariton condensates can be precisely controlled by tuning the annular potential geometry. These petal-shaped condensates form in multiple orbital states, carrying locked alternating π phase shifts and vortex–antivortex superposition cores, arising from the coupling of counterrotating exciton-polaritons in the confined circular waveguide. Our geometrically patterned microcavity exhibits promise for realizing room-temperature topological polaritonic devices and optical polaritonic switches based on periodic annular potentials.
HuR up-regulates cell surface PD-L1 via stabilizing CMTM6 transcript in cancer
Authors: Liu Yanbin , Li Xingzhi , Zhang Hui , Zhang Mingming , Wei Yanli 
Published: March 2021

AbstractDespite the well-established role of CMTM6 in the stabilization of cell surface PD-L1 in cancer cells, the mechanisms underlying CMTM6 expression and regulation are still largely unknown. Here we unexpectedly find a strikingly positive correlation between CMTM6 and Hu-Antigen R (HuR) expression in most types of cancer. Mechanistically, we elucidate HuR stabilizes CMTM6 mRNA via direct association with AU-rich elements (AREs) in its 3′UTR and predominantly up-regulates CMTM6, which is readily abolished by HuR-specific inhibitor, MS-444. Phenotypically, we notice abundant cell surface PD-L1 in HuR-high cancer cells, which significantly inhibits immune activation of co-cultured T cells as indicated by IL-2 production. Treatment with MS-444 completely relieves immune suppression imposed by HuR-overexpression and further stimulates immune responses. Ectopic HuR accelerates allograft tumor progression in vivo, which is greatly compromised by simultaneous administration with MS-444. Our study uncovers a novel mechanism in control of CMTM6 and therefore PD-L1 expression, and suggests the potential of combining HuR inhibitor with PD-1/PD-L1 antibodies for cancer immunotherapy.
IL-17B/IL-17RB signaling cascade contributes to self-renewal and tumorigenesis of cancer stem cells by regulating Beclin-1 ubiquitination
Authors: Bie Qingli , Song Hui , Chen Xinke , Yang Xiao , Shi Shuo , Zhang Lihua , Zhao Rou , Wei Li , Zhang Baogui , Xiong Huabao , Zhang Bin 
Published: March 2021

AbstractCancer stem cells (CSCs) are characterized by robust self-renewal and tumorigenesis and are responsible for metastasis, drug resistance, and angiogenesis. However, the molecular mechanisms for the regulation of CSC homeostasis are incompletely understood. This study demonstrated that the interleukin-17 (IL-17)B/IL-17RB signaling cascade promotes the self-renewal and tumorigenesis of CSCs by inducing Beclin-1 ubiquitination. We found that IL-17RB expression was significantly upregulated in spheroid cells and Lgr5-positive cells from the same tumor tissues of patients with gastric cancer (GC), which was closely correlated with the degree of cancer cell differentiation. Recombinant IL-17B (rIL-17B) promoted the sphere-formation ability of CSCs in vitro and enhanced tumor growth and metastasis in vivo. Interestingly, IL-17B induced autophagosome formation and cleavage-mediated transformation of LC3 in CSCs and 293T cells. Furthermore, inhibition of autophagy activation by ATG7 knockdown reversed rIL-17B-induced self-renewal of GC cells. In addition, we showed that IL-17B also promoted K63-mediated ubiquitination of Beclin-1 by mediating the binding of tumor necrosis factor receptor-associated factor 6 to Beclin-1. Silencing IL-17RB expression abrogated the effects of IL-17B on Beclin-1 ubiquitination and autophagy activation in GC cells. Finally, we showed that IL-17B level in the serum of GC patients was positively correlated with IL-17RB expression in GC tissues, and IL-17B could induce IL-17RB expression in GC cells. Overall, the results elucidate the novel functions of IL-17B for CSCs and suggest that the intervention of the IL-17B/IL-17RB signaling pathway may provide new therapeutic targets for the treatment of cancer.
Relapsed multiple myeloma demonstrates distinct patterns of immune microenvironment and malignant cell-mediated immunosuppression
Authors: Visram Alissa , Dasari Surendra , Anderson Emilie , Kumar Shaji , Kourelis Taxiarchis V. 
Published: March 2021

AbstractImmunotherapy has shown efficacy in relapsed multiple myeloma (MM). However, these therapies may depend on a functional tumor immune microenvironment (iTME) for their efficacy. Characterizing the evolution of the iTME over the disease course is necessary to optimize the timing of immunotherapies. We performed mass cytometry, cytokine analysis, and RNA sequencing on bone marrow samples from 39 (13 newly diagnosed [NDMM], 11 relapsed pre-daratumumab exposure [RMM], and 13 triple-refractory [TRMM]) MM patients. Three distinct cellular iTME clusters were identified; cluster 1 comprised mainly of NDMM and RMM patients; and clusters 2 and 3 comprised primarily of TRMM patients. We showed that naive T cells were decreased in clusters 2 and 3, cluster 2 was characterized by increased senescent T cells, and cluster 3 by decreased early memory T cells. Plasma cells in clusters 2 and 3 upregulated E2F transcription factors and MYC proliferation pathways, and downregulated interferon, TGF-beta, interleuking-6, and TNF-αlpha signaling pathways compared to cluster 1. This study suggests that the MM iTME becomes increasingly dysfunctional with therapy whereas the MM clone may be less dependent on inflammation-mediated growth pathways and less sensitive to IFN-mediated immunosurveillance. Our findings may explain the decreased sensitivity of TRMM patients to novel immunotherapies.
Therapeutic outcome of early-phase clinical trials in multiple myeloma: a meta-analysis
Authors: van Nieuwenhuijzen Niels , Frunt Rowan , May Anne M. , Minnema Monique C. 
Published: March 2021

AbstractGreat progress in the treatment of patients with multiple myeloma (MM) has been made due to the development of novel drugs. Patients with relapsed/refractory MM (RRMM) can be enrolled in early-phase clinical trials, but their performance across the last decade is unknown. We conducted a meta-analysis on the overall response rate (ORR) and toxicity. PubMed, Embase, and Cochrane Library were systematically searched for phase I and phase II trials investigating an experimental compound as a single agent or in combination with dexamethasone, published from January 1, 2010 to July 1, 2020. Eighty-eight articles were included, describing 61 phase I trials involving 1835 patients and 37 phase II trials involving 2644 patients. There was a high degree of heterogeneity. Using a random-effects model, the 95% CIs of the estimated ORR were 8–17% for phase I trials and 18–28% for phase II trials. There were significant subgroup differences in ORR between the years of publication in phase I trials and between drug classes in both phase I and phase II trials. The ORR in early-phase clinical trials in RRMM is substantial, especially in phase II trials, but due to high heterogeneity a general assessment of clinical benefit before participation is difficult to offer to patients.
A guide for kernel generalized regression methods for genomic-enabled prediction
Authors: Montesinos-López Abelardo , Montesinos-López Osval Antonio , Montesinos-López José Cricelio , Flores-Cortes Carlos Alberto , de la Rosa Roberto , Crossa José 
Published: March 2021

AbstractThe primary objective of this paper is to provide a guide on implementing Bayesian generalized kernel regression methods for genomic prediction in the statistical software R. Such methods are quite efficient for capturing complex non-linear patterns that conventional linear regression models cannot. Furthermore, these methods are also powerful for leveraging environmental covariates, such as genotype × environment (G×E) prediction, among others. In this study we provide the building process of seven kernel methods: linear, polynomial, sigmoid, Gaussian, Exponential, Arc-cosine 1 and Arc-cosine L. Additionally, we highlight illustrative examples for implementing exact kernel methods for genomic prediction under a single-environment, a multi-environment and multi-trait framework, as well as for the implementation of sparse kernel methods under a multi-environment framework. These examples are followed by a discussion on the strengths and limitations of kernel methods and, subsequently by conclusions about the main contributions of this paper.
Comparative analysis of long noncoding RNAs in angiosperms and characterization of long noncoding RNAs in response to heat stress in Chinese cabbage
Authors: Song Xiaoming , Hu Jingjing , Wu Tong , Yang Qihang , Feng Xuehuan , Lin Hao , Feng Shuyan , Cui Chunlin , Yu Ying , Zhou Rong , Gong Ke , Yu Tong , Pei Qiaoying , Li Nan 
Published: March 2021

AbstractLong noncoding RNAs (lncRNAs) are widely present in different species and play critical roles in response to abiotic stresses. However, the functions of lncRNAs in Chinese cabbage under heat stress remain unknown. Here, we first conducted a global comparative analysis of 247,242 lncRNAs among 37 species. The results indicated that lncRNAs were poorly conserved among different species, and only 960 lncRNAs were homologous to 524 miRNA precursors. We then carried out lncRNA sequencing for a genome-wide analysis of lncRNAs and their target genes in Chinese cabbage at different stages of heat treatment. In total, 18,253 lncRNAs were identified, of which 1229 differentially expressed (DE) lncRNAs were characterized as being heat-responsive. The ceRNA network revealed that 38 lncRNAs, 16 miRNAs, and 167 mRNAs were involved in the heat response in Chinese cabbage. Combined analysis of the cis- and trans-regulated genes indicated that the targets of DE lncRNAs were significantly enriched in the “protein processing in endoplasmic reticulum” and “plant hormone signal transduction” pathways. Furthermore, the majority of HSP and PYL genes involved in these two pathways exhibited similar expression patterns and responded to heat stress rapidly. Based on the networks of DE lncRNA-mRNAs, 29 and 22 lncRNAs were found to interact with HSP and PYL genes, respectively. Finally, the expression of several critical lncRNAs and their targets was verified by qRT-PCR. Overall, we conducted a comparative analysis of lncRNAs among 37 species and performed a comprehensive analysis of lncRNAs in Chinese cabbage. Our findings expand the knowledge of lncRNAs involved in the heat stress response in Chinese cabbage, and the identified lncRNAs provide an abundance of resources for future comparative and functional studies.
Tracing founder haplotypes of Japanese apple varieties: application in genomic prediction and genome-wide association study
Authors: Minamikawa Mai F. , Kunihisa Miyuki , Noshita Koji , Moriya Shigeki , Abe Kazuyuki , Hayashi Takeshi , Katayose Yuichi , Matsumoto Toshimi , Nishitani Chikako , Terakami Shingo , Yamamoto Toshiya , Iwata Hiroyoshi 
Published: March 2021

AbstractHaplotypes provide useful information for genomics-based approaches, genomic prediction, and genome-wide association study. As a small number of superior founders have contributed largely to the breeding history of fruit trees, the information of founder haplotypes may be relevant for performing the genomics-based approaches in these plants. In this study, we proposed a method to estimate 14 haplotypes from 7 founders and automatically trace the haplotypes forward to apple parental (185 varieties) and breeding (659 F1individuals from 16 full-sib families) populations based on 11,786 single-nucleotide polymorphisms, by combining multiple algorithms. Overall, 92% of the single-nucleotide polymorphisms information in the parental and breeding populations was characterized by the 14 founder haplotypes. The use of founder haplotype information improved the accuracy of genomic prediction in 7 traits and the resolution of genome-wide association study in 13 out of 27 fruit quality traits analyzed in this study. We also visualized the significant propagation of the founder haplotype with the largest genetic effect in genome-wide association study over the pedigree tree of the parental population. These results suggest that the information of founder haplotypes can be useful for not only genetic improvement of fruit quality traits in apples but also for understanding the selection history of founder haplotypes in the breeding program of Japanese apple varieties.
Characterisation and utilisation of nano-reduced starch from underutilised cereals for delivery of folic acid through human GI tract
Authors: Jhan Faiza , Gani Asir , Noor Nairah , Ashraf Zanoor ul , Gani Adil , Shah Asima 
Published: March 2021

AbstractBall milling offers green approach for size reduction of starch granules to nano scale size. In this research work, the starch from two underutilised cereal varieties viz. foxtail starch (FS) and sorghum starch (SS) were milled to achieve the desired nanometric range with mean particle diameter of 467.98 and 271.12 nm for nano foxtail (FSN) and nano sorghum starch (SSN), which were highly stable as revealed by zeta potential analysis. Functional attributes like solubility, swelling index, apparent amylose content, emulsifying and pasting properties were evaluated. Scanning electron microscopy (SEM) clearly revealed damaged starch granules produed by the process of milling. X-ray diffraction (XRD) displayed decrease in crystallinity upon milling to 16.08% (SSN) and 18.56% (FSN) and disappearance of some peaks. Attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR) also revealed reduced crystallinity as confirmed by the decreased absorbance ratio of 1047/1022 cm−1 in nano starch particles. Rheological analysis displayed shear thinning behaviour of nano starch samples as evaluated using Herschel-bulkely model and Power law. The nano starch samples exhibited comparatively low thermal gelatinisation temperatures as compared to native counter particles. Moreover, the nano-encapsulated starch samples offered more resistance to in-vitro digestion and showed control release of folic acid at target sites.
Denitrifying bacterial communities in surface-flow constructed wetlands during different seasons: characteristics and relationships with environment factors
Authors: Wei Jia-ming , Cui Li-juan , Li Wei , Ping Yun-mei , Li Wan 
Published: March 2021

AbstractDenitrification is an important part of the nitrogen cycle and the key step to removal of nitrogen in surface-flow wetlands. In this study, we explored space–time analysis with high-throughput sequencing to elucidate the relationships between denitrifying bacteria community structures and environmental factors during different seasons. Our results showed that along the flow direction of different processing units, there were dynamic changes in physical and chemical indicators. The bacterial abundance indexes (ACEs) in May, August, and October were 686.8, 686.8, and 996.2, respectively, whereas the Shannon-Weiner indexes were 3.718, 4.303, and 4.432, respectively. Along the flow direction, the denitrifying bacterial abundance initially increased and then decreased subsequently during the same months, although diversity tended to increase. The abundance showed similar changes during the different months. Surface flow wetlands mainly contained the following denitrifying bacteria genus: unclassified Bacteria (37.12%), unclassified Proteobacteria (18.16%), Dechloromonas (16.21%), unranked environmental samples (12.51%), unclassified Betaproteobacteria (9.73%), unclassified Rhodocyclaceae (2.14%), and Rhodanobacter (1.51%). During different seasons, the same unit showed alternating changes, and during the same season, bacterial community structures were influenced by the second genus proportion in different processing units. ACEs were strongly correlated with temperature, dissolved oxygen, and pH. Bacterial diversity was strongly correlated with temperature, electrical conductivity, pH, and oxidation reduction potential. Denitrifying bacteria are greatly affected by environmental factors such as temperature and pH.
Tardigrades of Kristianstads Vattenrike Biosphere Reserve with description of four new species from Sweden
Authors: Massa Edoardo , Guidetti Roberto , Cesari Michele , Rebecchi Lorena , Jönsson K. Ingemar 
Published: March 2021

AbstractKristianstads Vattenrike Biosphere Reserve [KVBR] is a UNESCO designated area of Sweden possessing high biological value. Although several studies on tardigrades inhabiting Sweden have been performed, the KVBR area has been neglected. The current study investigates the tardigrade fauna of five areas of the biosphere reserve and includes 34 samples of different substrates analysed quantitatively and qualitatively. In total, 33 species of tardigrades were found in the samples, including 22 new records for the Skåne region, 15 new records for Sweden, and four species new to science. Mesobiotus emiliae sp. nov., Xerobiotus gretae sp. nov., Itaquascon magnussoni sp. nov., and Thulinius gustavi sp. nov. were described with an integrative approach (when possible) using morphological characters (light, electron scanning, and confocal laser scanning microscopies) and molecular markers (ITS2, 18S, 28S, cox1). A new protocol to increase morphological data was developed recovering mounted specimens within old slides for SEM analysis. Emended diagnoses for the genus Itaquascon and the transfer of Platicrista itaquasconoide to the genus Meplitumen are proposed. This study enriches the knowledge of the tardigrade biodiversity both within the KVBR and in Sweden and contributes to the rapidly increasing number of tardigrade species reported worldwide. The 33 species identified in the KVBR area represents 28% of all water bear species found in Sweden so far. The restricted study areas and limited number of samples collected suggests that the KVBR is very rich of tardigrades.