bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Model for Tilting Pad Thrust Bearings Operating With Reduced Flow Rate – Do Benefits Outweigh Risks?
Authors: Koosha Rasool , San Andrés Luis 
Published: September 2021

Abstract
The literature on tilting pad thrust bearings (TPTB) calls for flow reduction as an effective means to reduce drag power losses as well as oil pumping costs. However, the highest level of flow reduction a bearing can undergo while maintaining reliable operation is a key question that demands comprehensive analysis. This paper implements a model into an existing thermoelasto-hydrodynamic (TEHD) computational analysis tool to deliver load performance predictions for TPTBs operating with reduced flow rates. For bearings supplied with either a reduced flow or an over flow conditions, a sound model for the flow and thermal energy mixing in a feed groove determines the temperature of the lubricant entering a thrust pad. Under a reduced flow condition, the analysis reduces the effective arc length of a wetted pad until matching the available flow. Predicted discharge flow temperature rise and pad subsurface temperature rise from the present model match measurements in the archival literature for an eight-pad bearing supplied with 150% to 25% of the nominal flow rate, i.e., the minimum flow that fully lubricates the bearing pads. A supply flow above nominal rate increases the bearing drag power because the lubricant enters a pad at a lower temperature, and yet has little effect on a thrust pad peak temperature rise or its minimum film thickness. A reduced flow below nominal produces areas lubricant starvation zones, and thus the minimum film thickness substantially decreases while the film and pad’s surface temperature rapidly increase to produce significant thermal crowning of the pad surface. Compared to the bearing lubricated with a nominal rate, a starved flow bearing produces a larger axial stiffness and a lesser damping coefficient. A reduction in drag power with less lubricant supplied brings an immediate energy efficiency improvement to bearing operation. However, sustained long-term operation with overly warm pad temperatures could reduce the reliability of the mechanical element and its ultimate failure.
Normative data and percentile curves for axial length and axial length/corneal curvature in Chinese children and adolescents aged 4–18 years
Authors: He Xiangui , Sankaridurg Padmaja , Naduvilath Thomas , Wang Jingjing , Xiong Shuyu , Weng Rebecca , Du Linlin , Chen Jun , Zou Haidong , Xu Xun 
Published: September 2021

PurposeTo develop age-specific and gender-specific reference percentile charts for axial length (AL) and AL/corneal radius of curvature (AL/CR) and, to use percentiles to determine probability of myopia and estimate refractive error (RE).MethodsAnalysis of AL, cycloplegic RE and CR of 14 127 Chinese participants aged 4–18 years from 3 studies. AL and AL/CR percentiles estimated using Lambda-Mu-Sigma method and compared for agreement using intraclass correlation (ICC). Logistic regression was used to model risk of myopia based on age, gender, AL and AL/CR percentiles. Accuracy of AL progression and RE estimated using percentiles was validated using an independent sample of 5742 eyes of children aged 7–10 years.ResultsAge-specific and gender-specific AL and AL/CR (3rd, 5th, 10th, 25th, 50th, 75th, 90th and 95th) percentiles are presented. Concordance between AL and AL/CR percentiles improved with age (0.13 at 4 years to >0.75 from 13 years) and a year-to-year change was observed for all except <10th percentile from 15 years. Increasing age, AL and AL/CR was associated with a more myopic RE (r2=0.45,0.70 and 0.83, respectively). The sensitivity and specificity of the model to estimate probability of myopia was 86.0% and 84.5%, respectively. Estimation of 1-year change in AL using percentiles correlated highly with actual AL (ICC=0.98). Concordance of estimated to actual RE was high (ICC=0.80) and within ±0.50D and ±1.0D of actual RE for 47.4% and 78.9% of eyes, respectively.ConclusionAge-specific and gender-specific AL and AL/CR percentiles provide reference data, aid in identifying and monitoring individuals at risk of myopia and have utility in screening for myopia. AL/CR percentiles were more accurate in estimating probability of myopia in younger children.
Spectral domain optical coherence tomography-based retinochoroidal cystine crystal score: a window into infantile nephropathic cystinosis
Authors: Keidel Leonie , Hohenfellner Katharina , Schworm Benedikt , Priglinger Siegfried , Luft Nikolaus , Priglinger Claudia 
Published: September 2021

PrécisCystinosis is a lysosomal storage disease leading to an accumulation of cystine crystals in several organs. We aim to comprehensively describe chorioretinal cystine crystals via spectral domain optical coherence tomography (SD-OCT) and elaborate a new biomarker for systemic disease control.Background/aimsCystinosis is a rare lysosomal storage disease leading to an accumulation of cystine crystals in several organs. This study aims to describe the deposition of retinochoroidal crystals in infantile nephropathic cystinosis and to elucidate their potential value as an objective biomarker for systemic disease control.MethodsThis cross-sectional study was carried out by the University Eye Hospital of the Ludwig-Maximilian University (Munich, Germany) in collaboration with the German Cystinosis Study Group. A complete ophthalmologic examination was performed, along with posterior segment SD-OCT (Spectralis; Heidelberg Engineering GmbH, Heidelberg, Germany). Retinochoroidal crystals were graded by employing a novel semiquantitative grading system—the retinochoroidal cystine crystal score (RCCCS). To quantify quality of vision, patients completed a specific questionnaire. A total of 85 eyes of 43 patients with cystinosis were included (mean age 22.3±8.8 years, range 6–39; male:female ratio=23:20).ResultsCystine crystals were detectable in all neuroretinal layers and the choroid, most frequently in the choriocapillaris. The RCCCS was negatively correlated with cysteamine intake (r=0.533, p=0.001) and positively with cystatin C, a stable parameter of renal function (r=0.496, p=0.016). Moreover, the value of the RCCCS affected subjective quality of vision. Genetic analysis indicated pronounced crystal deposition in patients with heterozygous mutations containing the 57-kb-deletion allele of theCTNSgene.ConclusionOcular cystinosis leads to retinochoroidal crystal accumulation in every stage of the disease. Crystal deposition may be markedly influenced by oral cysteamine therapy. Therefore, the presented SD-OCT based grading system might serve as an objective biomarker for systemic disease control.
Ross for Valve replacement In AduLts (REVIVAL) pilot trial: rationale and design of a randomised controlled trial
Authors: Whitlock Richard , Belley-Cote Emilie , Rega Filip , Chu Michael W.A. , McClure Graham R , Hronyecz Hanna , Verbrugghe Peter , Devereaux PJ , Bangdiwala Shrikant , Eikelboom John , Brady Katheryn , Sharifulin Ravil , Bogachev-Prokophiev Alexander , Stoica Serban 
Published: September 2021

IntroductionIn non-elderly adults, aortic valve replacement (AVR) with conventional prostheses yield poor long-term outcomes. Recent publications suggest a benefit of the Ross procedure over conventional AVR and highlight the need for high-quality randomised controlled trial (RCTs) on the optimal AVR. We have initiated a pilot trial assess two feasibility criteria and one assumption: (1) evaluate the capacity to enrol six patients per centre per year in at least five international centre, (2) validate greater than 90% compliance with allocation and (3) to validate the proportion of mechanical (≥65%) vs biological (≤35%) valves in the conventional arm.Methods and analysisRoss for Valve replacement In AduLts (REVIVAL) is a multinational, expertise-based RCT in adults aged 18–60 years undergoing AVR, comparing the Ross procedure versus one of the alternative approaches (mechanical vs stented or stentless bioprosthesis). The feasibility objectives will be assessed after randomising 60 patients; we will then make a decision regarding whether to expand the trial with the current protocol. We will ultimately examine the impact of the Ross procedure as compared with conventional AVR in non-elderly adults on survival free of valve-related life-threatening complications (major bleeding, systemic thromboembolism, valve thrombosis and valve reoperation) over the duration of follow-up. The objectives of the pilot trial will be analysed using descriptive statistics. In the full trial, the intention-to-treat principle will guide all primary analyses. A time-to-event analysis will be performed and Kaplan-Meier survival curves with comparison between groups using a log rank test will be presented.Ethics and disseminationREVIVAL will answer whether non-elderly adults benefit from the Ross procedure over conventional valve replacement. The final results at major meetings, journals, regional seminars, hospital rounds and via the Reducing Global Perioperative Risk Multimedia Resource Centre.Trial registration numberClinicalTrials.gov Identifier:NCT03798782Protocol versionJanuary 29, 2019 (Final Version 1.0)
Health service utilisation among African migrants in China: a nationwide cross-sectional study
Authors: Xiong Ming Zhou , Zhao Peizhen , Zou Xia , Hall Brian , Cao Honghua , Wang Cheng 
Published: September 2021

ObjectivesTo assess the health utilisation status and associated factors among African migrants in China.DesignA national cross-sectional study was conducted among African migrants in China in 2019.SettingParticipants were recruited online and offline to participate in a self-report survey. Online participants were recruited through WeChat across China, and offline participants were recruited in Guangzhou.ParticipantsWe recruited participants who were from an African country; had spent at least 1 month cumulatively in China; were at least 18 years old; were willing to provide informed consent. A total of 1025 participants were recruited online and offline, 19 of them were excluded due to invalid response and 1006 people were finally included in the analysis.Outcome measuresThe primary outcome was health service utilisation and associated factors among African migrants during their stay in China in the past 12 months. The potential factors include the predisposing factors (demographic characteristics and social structure variables), enabling factors (annual income, health insurance in China) and need factors (non-communicable chronic and infectious diseases, depression) which determined by Anderson framework were measured.ResultsEight hundred and seven online and 218 offline participants completed the survey, including 624 males and 382 females, with an average age of 26.4±8.9 years. Around 28.5% reported health utilization in the past 12 months. Results showed that longer duration in China, migration to China for business (aOR=2.23, 95% CI:1.13-4.40) and study (aOR=5.00, 95% CI:2.74-9.11), living in apartment (aOR=2.59, 95% CI:1.62-4.14) or dormitory (aOR=3.22, 95% CI:2.17-4.80) in China, suffering from chronic diseases, communicable diseases, and greater depressive symptoms (aOR=1.91, 95% CI:1.42-2.56) facilitated health service utilization.ConclusionsThe healthcare service that African migrants received in China is low. The existing public health policies and intervention measures need to be improved to make health utilisation more accessible and feasible for African migrants.
Relationship between cerebral aneurysms and variations in cerebral basal arterial network: a morphometric cross-sectional study in Computed Tomography Angiograms from a neurointerventional unit
Authors: Burlakoti Arjun , Kumaratilake Jaliya , Taylor Jamie , Henneberg Maciej 
Published: September 2021

ObjectiveSegments of cerebral basal arterial network (CBAN) dampen the peak pressure in blood flowing through these arteries, thus minimising the chances of development of cerebral aneurysms. The objective of this research was to find the relationship of occurrence of intracranial aneurysms to variations of the components of the CBAN.Design and settingThis is an observational, quantitative and retrospective research, which used cerebral CT angiography (CCTA) images.ParticipantsCerebral CTA of 145 adult patients of both sexes were studied.Main outcome measuresDiameters of segments of CBAN were measured in CCTA images and the relative size of each vessel was calculated to standardise for differences in overall arterial sizes among patients. Relationships among sizes of CBAN components were analysed. Presence of aneurysms in different parts of the CBAN was recorded.ResultsForty-six aneurysms in right internal carotid artery (ICA) and middle cerebral artery (MCA) and 32 aneurysms in left ICA and MCA segments were noted in 42 and 30 patients, respectively. Aneurysms in anterior communicating artery complex and vertebral-basilar arterial segments were seen in 27 and 8 patients, respectively, while they were not detected in parts of posterior cerebral artery (PCA). The significant (p<0.001) inverse relationships between sizes of posterior communicating artery and the first segment of PCA on both sides indicated that blood inputs to the second part of PCA were similar. Difference in means of the index of arterial size variation for people with aneurysms (mean 0.96, SD 0.23) and without aneurysms (mean 0.86, SD 0.22) was significant (p=0.015).ConclusionVariation in segments of CBAN was quantified. The peak pressure dampening mechanism in such arterial segments reduces the chances of development of aneurysms.
Thyroid diagnostic modalities (fine needle aspiration and core needle biopsy) with histology correlation: a tertiary centre experience
Authors: Appukutty Sona J , Paterson Anna , Patel Nishant S , Duckworth Adam , Chan James , O'Donovan Maria , Marker Alison J 
Published: September 2021

AimsTo determine the proportion of thyroid fine needle aspiration (FNA) and core needle biopsy (CNB) cases reported at a single institute into each UK Royal College of Pathologists (RCPath) Thy1-5 and local T category, respectively. Where subsequent histology was available, malignancy rates, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy were compared for both procedures.Methods1591 FNAs (2010–2018) and 514 CNBs (2013–2018) cases were identified, together with paired histology excision specimens.ResultsThe FNA samples were classified as: Thy1: 45.3%, Thy2/Thy2c: 22.1%, Thy3a/Thy3f: 28%, Thy4: 1.6% and Thy5: 3%; while the CNB were classified as: T1: 7.2%, T2: 22.4%, T3 59.3%, T4: 1% and T5: 10.1%. Comparison of FNA and CNB classified as Thy5/T5 showed a 100% risk of malignancy (ROM), sensitivity (98% vs 100%), specificity (14.1% vs 12.1%), PPV (29.4% vs 29.4%), NPV (94.9% vs 100%) and accuracy (36.5% vs 35.6%), respectively, for a diagnosis of malignancy. ROMs for other categories were: Thy1/T1 (9% vs 6.7%), Thy2/T2 (5.1% vs 0%), Thy3/T3 (17.5% vs 18.4%) and Thy4/T4 (73.3% vs 100%).ConclusionsThe proportion of cases in each RCPath Thy category has remained relatively stable during the 9-year study period, with the exception of the Thy3a category, which has increased over time. This finding is in line with other more recent reports in the literature and the proportion of T3 cases in the CNB group. The proportion of Thy2/Thy2c cases has also reduced over time, reflecting a local change in the triaging protocol for probable benign lesions. Both FNA and CNB showed comparable performance in our study.
Leading by virtual interaction: an application of cultural-historical activity theory
Authors: Sjaus Ana , Ritchie Krista Corinne 
Published: September 2021

IntroductionThe pandemic spread of SARS-CoV-2, a novel, highly contagious and easily transmissible pathogen, has profoundly affected all aspects of human interaction. Guided by the need to reduce face-to-face contacts, medical organisations have rapidly shifted group activities to virtual platforms. Over 1 year into the pandemic, the necessity to maintain public health restrictions ensures that virtual meetings will be the norm for the foreseeable future.It has yet to be understood how virtual technologies shape healthcare and academic cultures, affect interactions, or influence strategic decisions and policies within these systems.ConclusionIn this article, the authors reflect on the move from historically situated activity systems of team leadership in healthcare to ones that now exist in virtual formats. Cultural-historical activity theory (CHAT) is a framework that explains complex human actions, and how they unfold over time through interaction with mediational tools (eg, technology) and various people representing their own communities, roles and perceived divisions of labour. The authors use the lens of CHAT as a framework to understand the shifting dynamics at play and offer strategies for leaders to co-establish activity systems with team members to make goals of group activities explicit and to deliberately work toward them. Five specific strategies proposed are: (1) use software platforms that fit your needs and give voice to all attendees with technical support present in meetings; (2) converse explicitly about roles and emerging role fluidity during times of change and pandemic response; (3) co-construct something new intentionally; (4) engage in implementation science at this time; and (5) lead intentionally while honouring cultural norms and values. It is imperative that any changes, even the ones that are a part of the pandemic response, are made consistent with the core shared values of the medical community as this necessary new way of coming together is embraced with collective wisdom.
Arguments used by proponents and opponents in Brazil’s regulatory discussions of e-cigarettes and heated tobacco products
Authors: Nunes-Rubinstein Mônica , Leão Teresa 
Published: September 2021

ObjectivesTo identify proponents and opponents of the commercialisation and marketing of e-cigarettes and heated tobacco products (HTPs), identify the arguments used on both sides and compare how the arguments have changed over time, we analysed three policy discussions occurring in 2009, 2018 and 2019.MethodsWe conducted a content analysis of one document and six videos from these discussions, provided on the Brazilian Health Regulatory Agency website, or upon request.ResultsThe arguments most used by tobacco companies were related to claims that the use of e-cigarettes and HTPs is less harmful than conventional tobacco. Unions that support its commercialisation also argued that lifting the ban would prevent smuggling and guarantee their quality. On the other side, universities, medical and anti-tobacco institutions argued that such devices may have health risks, including the risk of inducing cigarette smoking. In 2009, most arguments belonged to the ‘health’ theme, while in 2018 and 2019 economic arguments and those related to morals and ethics were frequently used.ConclusionsThose that supported the commercialisation and marketing of e-cigarettes and HTPs first focused on arguments of harm reduction, while 10 years later the right to access and potential economic consequences also became common. Public health agents and academics must gather evidence to effectively respond to these arguments and discuss these policies, and must prepare themselves to use and respond to arguments related to moral and economic themes.
Diffusion-Based Influence Maximization in GOLAP
Authors: Kim Mira , Shih Hsiang-Shun , Sheu Phillip C-Y. 
Published: September 2021

Influence analysis is one of the most important research in social network. Specifically, more and more researchers and advertisers are interested in the area of influence maximization (IM). The concept of influence among people or organizations has been the core basis for making business decisions as well as performing everyday social activities.In this research, we begin by extending a new influence diffusion model information diffusion model (IDM) using various constraints. We incorporate colors and additional nodes constraints. By adding colors and constraints for different types of nodes in a graph, we would be able to answer complex queries on multi-dimensional graphs such as ‘find at most two most important genes that are related to lung disease and heart disease’. More specifically, we discuss the following variations of IM-IDM; Colorblind IM-IDM, Colored IM-IDM and Colored IM-IDM with constraints. We also present our experiment results to prove the effectiveness of our model and algorithms.
Laboratory Demonstration of the Local Oscillator Concept for the Event Horizon Imager
Authors: Kudriashov V. , Martin-Neira M. , Lia E. , Michalski J. , Kant P. , Trofimowicz D. , Belloni M. , Jankovic P. , Waller P. , Brandt M. 
Published: September 2021

Black hole imaging challenges the third-generation space VLBI, the Very Long Baseline Interferometry, to operate on a 500[Formula: see text]GHz band. The coherent integration time needed here is 450[Formula: see text]s though the available space oscillators cannot offer more than 10[Formula: see text]s. Self-calibration methods might solve this issue in an interferometer formed by three antenna/satellite systems, but the need for the third satellite increases the mission costs. A frequency transfer is of special interest to alleviate both performance and cost issues. A concept of two-way optical frequency transfer is examined to investigate its suitability to enable space-to-space interferometry, in particular, to image the “shadows” of black holes from space. The concept, promising on paper, has been demonstrated by tests. The laboratory test set-up is presented and the verification of the temporal stability using standard analysis tool as TimePod has been passed. The resulting Allan Deviation is dominated by the 1/[Formula: see text] phase noise trend since the frequency transfer timescale of interest is shorter than 0.2[Formula: see text]s. This trend continues into longer integration times, as proven by the longest tests spanning over a few hours. The Allan Deviation between derived 103.2[Formula: see text]GHz oscillators is [Formula: see text]/[Formula: see text] within 10[Formula: see text][Formula: see text][Formula: see text]s that degrades twice towards the longest delay of 0.2[Formula: see text]s. The worst case satisfies the requirement with a margin of 11 times. The obtained coherence in the range of 0.997[Formula: see text]0.9998 is beneficial for space VLBI at 557[Formula: see text]GHz. The result is of special interest to future science missions for black hole imaging from space.