bluuebunny/crossref_metadata_2025_split huggingface dataset:
P589 Stable Trends in Radiation Exposure Amongst Patients with a New Diagnosis of Inflammatory Bowel Disease at an Irish Tertiary Referral Hospital
Authors: Matthews T J 
Published: May 2021

Abstract

Background
The utilisation of diagnostic imaging has risen dramatically over time. IBD patients are particularly vulnerable to this inclination.
We evaluated trends in the radiation doses to which our service exposed our new IBD referrals over time.

Methods
Searches of new referrals to our IBD clinic during two 24-month periods beginning 01/06/2005 (n=84) and 01/01/2013 (n=63) were conducted.
The numbers of AXRs, CT APs, Barium Swallows, Meals, Follow-Throughs and Enemas, CT Colonographies and MRI SBs were collated for each patient for the five-year period subsequent to their first attendance. The dataset was irrevocably anonymised. Cumulative effective radiation doses were calculated using estimates provided in leading radiology journals.
Linear regression using the ordinary least squares method examined the relationship between cumulative dose, period of diagnosis, age, gender and category of IBD.

Results
The mean cumulative effective radiation doses for the earlier and later periods were 4.7mSv (95% CI, 1.86 to 7.54) and 7.4mSv (95% CI, 3.60 to 11.26) respectively.
No significant relationship was demonstrated between age (-0.03mSv, 95%CIs: -0.20, 0.12), male gender (0.69mSv, 95%CIs: -4.00, 5.39), or later referral period (3.06mSv, 95%CIs: -1.67, 7.78) and cumulative dose. A diagnosis of Crohn’s (as opposed to UC) had a strongly positive relationship with total radiation dose (5.89, 95%CI: 1.07, 10.70).
12 MRI small bowels were completed during period 2, none during period 1.

Conclusion
Our evaluation shows an upward trend, failing to meet statistical significance, in the radiation doses to which patients with new diagnoses of IBD were exposed to by our service.
P598 Previous Intestinal Resection Is Associated with Postoperative Complications in Crohn’s Disease: A Cohort Study
Authors: Li Y , Duan Y , Zhiyuan Z , Danhua Y 
Published: May 2021

Abstract

Background
To assess the influence of a previous intestinal resection on postoperative complications for Crohn’s disease (CD).

Methods
Data on patients with CD undergoing surgery in our department from January 2016 through December 2019 were retrospectively reviewed. Information collected included demographic details, surgical data, and postoperative outcome. A cross- sectional study design was employed. Associations between postoperative complications and preoperative clinical indicators were further analyzed.

Results
Of the 129 patients with CD studied, 62 patients (48.06%) underwent previous resection. These patients were more likely to be older (P=0:031), have longer disease duration (P=0:025), use less 5-aminosalicylic acid/sulfasalazine preoperatively (P = 0:013), have lower body mass index (P = 0:003), and have a higher American Society of Anesthesiologists (ASA) Physical Status Classification System score (P = 0:043). Patients who had previous surgery had a longer duration of operation (P = 0:003), greater estimated blood loss (P = 0:001), and longer hospital stay (P &lt; 0:001) and were more inclined to develop postoperative complications (P=0:047), particularly anastomotic leak (P=0:021) and severe (Clavien– Dindo grade III/IV) complications (P = 0:038). After multivariate analysis, previous intestinal resection (P = 0:019), preoperative use of steroids (P = 0:026), and ASA score of more than II (P &lt; 0:001) were determined to be the independent prognostic risk factors for postoperative complications. During the 30-day follow-up period, there was no postoperative mortality or readmission.

Conclusion
Previous intestinal resection in patients with CD is an independent predictor of overall postoperative complications.
P680 Similar gut bacterial composition between patients with ulcerative colitis and healthy controls in a high prevalence population: a cross-sectional study of the Faroe Islands IBD cohort
Authors: Á Fríðriksmørk Berbisá M , Rubek Nielsen K , Midjord J , Oddmarsdóttir Gregersen N , Ingham A C , Burisch J , Gratton Vang A 
Published: May 2021

Abstract

Background
The Faroe Islands, a genetically and geographically isolated population in the North Atlantic, has the world’s highest prevalence of inflammatory bowel disease (IBD). Epidemiological studies have characterized this unique cohort, which consists predominately of an ulcerative colitis phenotype, and a decreased risk of developing IBD with emigration. Therefore, the well-characterized Faroese IBD cohort gives the opportunity to better understand the interplay between genetic predisposition and environmental triggers for this complex disease. This study represents the first investigation into the composition of the gut microbiome for the cohort.

Methods
This cross-sectional study consisted of 41 patients with established ulcerative colitis (UC) and 144 age-and sex matched healthy controls (HC) recruited through the Faroese Genome project (FarGen). Participants donated a one-time fecal sample and completed questionnaires on food-frequency, background health and lifestyle. DNA extractions were completed and 16S rRNA amplicon sequencing of the V3-V4 region was performed followed by bioinformatic analysis of taxonomy and diversity metrics.

Results
The overall composition of the sequenced fecal bacteria was dominated by Firmicutes (64,5% of total amplicon sequence variants) and Bacteroidetes (20,95% of total amplicon sequence variants). Akkermansia muciniphila was absent from 30% of the study samples. Discriminatory analysis for indicator taxa identified that Coprococcus and Prevotella_9 characterized healthy controls while genus Ruminiclostridium characterizes UC patients. However, no statistically significant differences were found between UC and HC based on metrics of alpha or beta diversity. Food frequency questionnaires revealed no differences in dietary patterns of the two groups.

Conclusion
The similarity between the microbiome of Faroese UC and HC samples within this study and the absence of the beneficial taxa Akkermansia muciniphila in both groups, raises further questions concerning the underlying susceptibility toward inflammatory and metabolic disorders within this population. This study represents the first 16s rRNA amplicon sequencing data and insights into the Faroese UC and background population. The results highlight the importance of having regionally tuned reference ranges for microbial data.
Full spectroscopic model and trihybrid experimental-perturbative-variational line list for CN
Authors: Syme Anna-Maree , McKemmish Laura K 
Published: May 2021

ABSTRACT
Accurate line lists are important for the description of the spectroscopic nature of small molecules. While a line list for CN (an important molecule for chemistry and astrophysics) exists, no underlying energy spectroscopic model has been published, which is required to consider the sensitivity of transitions to a variation of the proton-to-electron mass ratio. Here we have developed a Duo energy spectroscopic model as well as a novel hybrid style line list for CN and its isotopologues, combining energy levels that are derived experimentally (Marvel), using the traditional/perturbative approach (Mollist), and the variational approach (from a Duo spectroscopic model using standard ExoMol methodology). The final Trihybrid ExoMol-style line list for 12C14N consists of 28 004 energy levels (6864 experimental, 1574 perturbative, the rest variational) and 2285 103 transitions up to 60 000 cm−1 between the three lowest electronic states (X 2Σ+, A 2Π, and B 2Σ+). The spectroscopic model created is used to evaluate CN as a molecular probe to constrain the variation of the proton-to-electron mass ratio; no overly promising sensitive transitions for extragalactic study were identified.
Constraining the solar neighbourhood age–metallicity relation from white dwarf–main sequence binaries
Authors: Rebassa-Mansergas A , Maldonado J , Raddi R , Knowles A T , Torres S , Hoskin M , Cunningham T , Hollands M , Ren J , Gänsicke B T , Tremblay P-E , Castro-Rodríguez N , Camisassa M , Koester D 
Published: May 2021

ABSTRACT
The age–metallicity relation (AMR) is a fundamental tool for constraining the chemical evolution of the Galactic disc. In this work, we analyse the observational properties of this relation using binary stars that have not interacted consisting of a white dwarf (WD) – from which we can derive the total age of the system – and a main sequence (MS) star – from which we can derive the metallicity as traced by the [Fe/H] abundances. Our sample consists of 46 widely separated, but unresolved spectroscopic binaries identified within the Sloan Digital Sky Survey, and 189 WD plus MS common proper motion pairs identified within the second data release of Gaia. This is currently the largest WD sample for which the metallicity of their progenitors have been determined. We find a flat AMR displaying a scatter of [Fe/H] abundances of approximately ±0.5 dex around the solar metallicity at all ages. This independently confirms the lack of correlation between age and metallicity in the solar neighbourhood that is found in previous studies focused on analysing single MS stars and open clusters.
The digital doctor: telemedicine in facial plastic surgery
Authors: Morisada Megan V. , Tollefson Travis T. , Shaye David A. , Steele Toby O. 
Published: May 2021

Purpose of review
In the setting of the COVID-19 global pandemic, the demand for and use of telemedicine has surged in facial plastic and reconstructive surgery. This review aims to objectively review and summarize the existing evidence for the use of telemedicine within facial plastic surgery.

Recent findings
Telemedicine has been successfully implemented among subsets of facial plastic surgery patients, with high patient and provider satisfaction. Although the technology to facilitate telemedicine exists and preliminary studies demonstrate promise, multiple technological, financial, and medical barriers may persist in the postpandemic era.

Summary
Telemedicine will likely continue to grow and expand within facial plastic surgery moving forward, and we should continue to critically evaluate patient selection, access to care, and strategies for effective implementation to enhance current clinical practices.
Indoor Thermal Environment of Various Semi-Enclosed Atrium Configurations of Institutional Building in Tropical Climate
Authors: Mohammad Yusoff Wardah Fatimah 
Published: May 2021

The consideration of local climate is essential for the application of atrium in building. Different strategies and approaches in atrium configuration are required for different climates in ensuring its effectiveness. Nevertheless, the final aim is still similar which is to provide a comfortable environment for the users. Hence, this study was executed to examine the effects of top and side configurations on the indoor thermal environment of semi-enclosed atrium in the tropical climate. The methodologies involved field measurement and questionnaire survey. The field measurements were executed at two different configurations of semi-enclosed atriums in the tropical climate of Malaysia. Meanwhile, the questionnaire surveys were executed simultaneously with the field measurements in obtaining the users’ thermal sensation and satisfaction. The findings indicated that the top configuration had more influence to the indoor thermal environment compared to the side configuration as it determined the amount of solar heat penetration into the atrium area. Meanwhile, the side configuration influenced the air velocity inside the atrium. The Faculty of Engineering and Built Environment’s atrium that has opaque top finishes was found to have the average indoor operative temperature of less than 30 °C throughout the day, though the average outdoor air temperature was more than 30 °C. It also had more hours with neutral thermal sensation felt by the users compared to the Faculty of Economics and Management’s atrium that has transparent materials for the top finishes. The study is useful in guiding the selection of appropriate strategy for an atrium in tropical climate
Cathemeral activity by brown-throated three-toed sloths (Bradypus variegatus) in central Amazonian flooded igapó forests
Authors: Castro-Sa Matheus J. , Dias-Silva Renann H.P. , Barnett Adrian A. 
Published: May 2021

Both biotic and abiotic factors are important for maintaining the activity cycles of animals and may determine the most advantageous periods for eating, moving, and sleeping. Although the solar day–night cycle is among the most central of abiotic variables, a number of species are active both day and night. Three-toed sloth (genus Bradypus Linnaeus, 1758) populations across the Neotropics show this pattern, with activity occurring at various times within the 24 h cycle. In the current study, we used radio-tracking techniques to investigate the daily temporal patterning of brown-throated three-toed sloth (Bradypus variegatus Schinz, 1825) displacement in Amazonian flooded igapó forest and compared the results with populations studied in other habitats. We concluded that igapó sloths are cathemeral, and discussed that environmental temperature, nutritional needs and the presence of predators may be the main factors influencing their activity pattern.
Focal Cerebral Arteriopathy of Childhood
Authors: Oesch Gabriela , Perez Francisco A. , Wainwright Mark S. , Shaw Dennis W.W. , Amlie-Lefond Catherine 
Published: May 2021

Background and Purpose:
Focal cerebral arteriopathy (FCA) of childhood with unilateral stenosis of the anterior circulation is reported to account for up to one-quarter of childhood arterial ischemic stroke, with stroke recurrence in 25% of cases. Limited knowledge regarding pathophysiology and outcome results in inconsistent treatment of FCA.

Methods:
Children with arterial ischemic stroke due to FCA between January 1, 2009, and January 1, 2019, were retrospectively identified at our institution which serves the US Pacific Northwest region. Electronic health record data, including neuroimaging studies, were reviewed, and the Pediatric Stroke Outcome Measure at 1 year was determined as the primary clinical end point.

Results:
Fifteen children were diagnosed with FCA, accounting for 19% of children with cerebral arteriopathies (n=77). Among children with FCA, the median age at the time of stroke was 6.8 years (Q1–Q3, 1.9–14.0 years). Four (20%) patients had worsening stroke, 3 of whom had concurrent infection. Three (20%) FCA cases were treated with steroids, one of whom had worsening stroke. Median Pediatric Stroke Outcome Measure at 1 year was 1.0 (Q1–Q3, 0.6–2.0). Variability in arteriopathy severity was observed within many patients. Patients with more severe arteriopathy using the Focal Cerebral Arteriopathy Severity Score had larger strokes and were more likely to have worsening stroke. The most common long-term neurological deficit was hemiparesis, which was present in 11 (73%) patients and associated with middle cerebral artery arteriopathy and infarcts.

Conclusions:
FCA may be less common than previously reported. Neuroimaging in FCA can help identify patients at greater risk for worsening stroke.
Variability of macro and microelement content in pods and leaves of the carob tree (Ceratonia siliqua L.) in Croatia
Authors: Müller Ivna Dragojević , Tariba Blanka , Čepo Dubravka Vitali , Vujić Lovorka , Ruščić Mirko , Bolarić Snježana , Kremer Dario 
Published: May 2021

ABSTRACT
The pods, seeds and leaves of the carob tree (Ceratonia siliqua L.) are widely used in the pharmaceutical industry, and especially in the food industry. In this study, the mineral content was investigated in carob pods and leaves in twelve Croatian carob populations. Macro and microelement contents, as highly important nutrients, were determined by inductively coupled plasma mass spectrometry (ICP-MS). Total ash content, determined by the gravimetric method, ranged from 2.30 to 2.97% in pods and from 4.95 to 7.90% in leaves. Among the macroelements, K content was highest in pods (9,020.09–11,208.97 mg/kg), while Ca was highest in leaves (11,059.67–22,756.81 mg/kg). Microelement contents ranged from 0.00 mg/kg (Cr) to 136.70 mg/kg (Na) in pods, and from 0.02 mg/kg (Cr) to 243.55 mg/kg (Na) in leaves. The results of the macro and microelement analyses were evaluated using multivariate analysis (PCA and UPGMA).
Late Spring and Summer Subseasonal forecasts in the Northern Hemisphere midlatitudes: biases and skill in the ECMWF model
Authors: Dutra Emanuel , Johannsen Frederico , Magnusson Linus 
Published: May 2021

AbstractSubseasonal forecasts lie between medium-range and seasonal time scales with an emerging attention due to the relevance in society and by the scientific challenges involved. This study aims to (i) evaluate the development of systematic errors with lead time in the European Centre for Medium-Range Weather Forecasts (ECMWF) ensemble forecasts of surface-related variables during late spring and summer, and (ii) investigate potential relationships between the systematic errors and predictive skill. The evaluation is performed over the northern hemisphere midlatitudes, focusing on several regions with different climate characteristics. The results indicate five key bias patterns: (i) cold bias of daily maximum temperature (mx2t) in the April-May forecasts at all lead times in most regions; (ii) central North America with a warm bias mostly in the daily minimum temperature (mn2t); (iii) East of Caspian Sea region with a warm and dry bias; (iv) Western and Mediterranean Europe with a cold bias in mn2t mainly in April-May forecasts and (v) continental Europe with a cold bias in the mx2t and warm bias of mn2t in the June-July forecasts. We also found substantial deviations of soil moisture and terrestrial water storage variation in most regions compared to ECMWF ERA5 reanalysis. Despite the large differences in the systematic error characteristics among the different regions, there is little relation to the skill of the subseasonal forecasts. The systematic temperature biases require further attention from model developers as diurnal cycle improvements could enhance some of the potential predictability coming from the long-memory effect of soil moisture.
Socio-economic factors do not affect overall survival in soft tissue sarcoma when patients treated at a single high-volume center
Authors: Eastman Boryana M. , Hippe Daniel S. , Wootton Landon S. , Nyflot Matthew J. , Thompson Matthew J. , Pollack Seth M. , Kim Edward , Spraker Matthew B. 
Published: May 2021

Abstract
Background
Treatments for soft tissue sarcoma (STS) include extensive surgical resection, radiation and chemotherapy, and can necessitate specialized care and excellent social support. Studies have demonstrated that socioeconomic factors, such as income, marital status, urban/rural residence, and educational attainment as well as treatment at high-volume institution may be associated with overall survival (OS) in STS.

Methods
In order to explore the effect of socio-economic factors on OS in patients treated at a high-volume center, we performed a retrospective analysis of STS patients treated at a single institution.

Results
Overall, 435 patients were included. Thirty-seven percent had grade 3 tumors and 44% had disease larger than 5 cm. Patients were most commonly privately insured (38%), married (67%) and retired or unemployed (43%). Median distance from the treatment center was 42 miles and median area deprivation index (ADI) was 5 (10 representing most deprived communities). The majority of patients (52%) were treated with neoadjuvant therapy followed by resection. As expected, higher tumor grade (HR 3.1), tumor size > 5 cm (HR 1.3), and involved lymph nodes (HR 3.2) were significantly associated with OS on multivariate analysis. Demographic and socioeconomic factors, including sex, age at diagnosis, marital status, employment status, urban vs. rural location, income, education, distance to the treatment center, and ADI were not associated with OS.

Conclusions
In contrast to prior studies, we did not identify a significant association between socioeconomic factors and OS of patients with STS when patients were treated at a single high-volume center. Treatment at a high volume institution may mitigate the importance of socio-economic factors in the OS of STS.
Evaluation of modifiable risk factors for peritoneal dialysis-related peritonitis: a single-center retrospective cohort study
Authors: Kojima Shigeki , Yamada Shohei , Fujishima Rie , Koitabashi Kenichiro , Shibagaki Yugo , Sakurada Tsutomu 
Published: May 2021

Abstract
Background
Peritoneal dialysis (PD)-related peritonitis risk factors can be categorized as modifiable and uncorrectable. We aimed to identify modifiable risk factors for PD-related peritonitis in our facility to prevent PD-related peritonitis and continue quality improvement.

Methods
This retrospective, observational study included 90 patients who started receiving PD after 2008 and who were continued for over 1 year. Twenty-three patients experienced 40 episodes of peritonitis. Several clinical factors identified at peritonitis onset among patients with a peritonitis history were compared with those identified 1 year after PD initiation among patients without a peritonitis history, and a multivariate analysis was performed. Several serum parameter levels were evaluated as time-average concentrations (TACs; from PD initiation to 1 month before peritonitis onset or to 1 year later). The clinical factors to be investigated were selected based on previous studies.

Results
There were no significant between-group differences in baseline characteristics regarding uncorrectable factors and TAC values for serum parameters. Use of exchange devices was significantly higher (95.7% vs 71.6%; p = 0.054) whereas administration of renin-angiotensin-aldosterone system (RAS) blockers, calcium channel blockers (CCBs), or oral vitamin D was significantly lower (35.0% vs 65.7%, p = 0.002; 55.0% vs 74.6%, p = 0.036; and 55.0% vs 74.6%, p = 0.036, respectively) in the patients with history of peritonitis, although we did not find a factor independently associated with peritonitis in multivariable logistic regression.

Conclusions
Although hypokalemia, hypoalbuminemia, and exchange device use which are considered as risk factors did not affect peritonitis, administration of RAS blockers, CCBs, and oral vitamin D is significantly larger in patients without peritonitis.
Apoio Matricial em Saúde Mental na Atenção Primária à Saúde: construções processuais
Authors: Dalla Vecchia Pereira Liana Cristina , Rodríguez Barone Luciana , Mainieri Paulon Simone 
Published: May 2021

O estudo aqui apresentado objetivou acompanhar o processo de apoio matricial em saúde mental em uma equipe de saúde da família no município de Porto Alegre para produzir conhecimento acerca deste dispositivo de cuidado. O Ministério da Saúde brasileiro aponta o apoio matricial como estratégia de mudança nos modos de gerir e cuidar em saúde, constituindo estratégia potente para a articulação das ações de saúde mental na atenção primária. A pesquisa utilizou-se do método cartográfico com a realização de três rodas de conversa e acompanhamento das reuniões entre equipe apoiadora e equipe de saúde da família durante oito meses. Analisaram-se os materiais registrados nos diários de campo, atas das reuniões de equipe e relatos das discussões de caso. O apoio matricial mostrou-se importante estratégia de interferência nos processos de trabalho, construído na singularidade dos encontros e nas descontinuidades do processo. Em alguns períodos, houve maior envolvimento das equipes nos espaços de discussão e gestão do cuidado, com reverberação do fazer junto através da realização de interconsultas e visitas na rede intersetorial. Em outros momentos, permeado pelas fragilizaçõesinstitucionais, este dispositivo foi importante para apoiar as/os trabalhadoras/es. Nesta experiência, o apoio matricial possibilitou ampliar o olhar e as ações de promoção de cuidados em saúde mental na atenção primária através da produção de saberes e práticas em ato.