bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of an immune-related signature indicating the dedifferentiation of thyroid cells
Authors: Wang Xuemin , Peng Wen , Li Chunyan , Qin Rujia , Zhong Zhaoming , Sun Chuan-Zheng 
Published: February 2021

Abstract
Background: Immune cells account for a large proportion of the tumour microenvironment in anaplastic thyroid carcinomas (ATCs). However, the expression pattern of immune-related genes (IRGs) in ATCs is unclear. Our study aimed to identify an immune-related signature indicating the dedifferentiation of thyroid cells.Methods: We compared the differences in thyroid differentiation score (TDS), infiltration of immune cells and enriched pathways between ATCs and papillary thyroid carcinomas (PTCs) or normal thyroid tissues in the Gene Expression Omnibus database. Univariate and multivariable Cox analyses were used to screen prognosis-associated IRGs in The Cancer Genome Atlas database. After constructing a risk score, we investigated its predictive value for differentiation and survival by applying receiver operating characteristic and Kaplan-Meier curves. We further explored its associations with important immune checkpoint molecules, infiltrating immune cells and response to immunotherapy. Results: Compared with PTCs or normal thyroid tissues, ATCs exhibited lower TDS values and higher enrichment of immune cells and activation of the inflammatory response. The quantitative analyses and immunohistochemical staining validated that most ATC cell lines and ATC tissues had higher expression of MMP9 and lower expression of SDC2 than normal thyroid samples and PTC. Higher risk scores indicates dedifferentiation and a worse prognosis. Additionally, the risk score was positively correlated with the immune checkpoint molecules PDL1, CTLA4, IDO1, and HAVCR2 and infiltration of multiple immune cells. Importantly, we found that the samples with higher risk scores tended to have a better response to immunotherapy than those with lower scores. Conclusion: Our findings indicate that the risk score may not only contribute to the determination of differentiation and prognosis of thyroid carcinomas but also help the prediction of immune cells infiltration and immunotherapy response.
Autocuidado en el psicólogo
Authors: Villarreal Silva Geidy Vanessa , Rodríguez Bustamante Alexander 
Published: February 2021

El hacer terapéutico se concentra principalmente en la alfabetización del paciente-consultante-cliente en el manejo de sus relaciones interpersonales, en las diferentes problemáticas motivo de consulta. Deja un poco relegado al terapeuta quien, también, sitúa en riesgo su propio ser en el contexto de la consulta, en la trama vincular consultante-terapeuta. Con esto en mente, el objetivo de este artículo tiene que ver con el desarrollo de habilidades de autocuidado en el psicólogo: un factor protector de la salud mental en el ejercicio profesional. Método: la revisión documental se realizó desde una orientación cualitativa que se basa en una descripción rigurosa de los hechos o situaciones, al mismo tiempo, se empleó una metodología hermenéutica; por medio del estado del arte se procuró comprender la literatura existente sobre la actual propuesta de investigación. Conclusiones: el autocuidado como un factor protector de la salud mental en el ejercicio profesional está encaminado a promover acciones de promoción y prevención a partir de habilidades de autorreflexividad y resiliencia frente al autocuidado en busca del bienestar y salud mental.
Adsorption of hexavalent chromium ions from aqueous solutions using nano-chitin: kinetic, isotherms and thermodynamic studies
Authors: Sheikhi Meghdad , Rezaei Hassan 
Published: February 2021

AbstractTreatment of the industrial wastewater before discharging into aquatic ecosystems using a new technology such as nanotechnology seems necessary. There are different methods for the removal of the heavy metals in the wastewater. In this study, nano-chitin was purchased from the Nano-Novin Polymer Company and used as an adsorbent for the removal of chromium (VI) ions from aqueous solution in a batch system. The effects of pH, temperature, contact time, concentration, and adsorbent dose were investigated. According to the results, the optimum conditions of adsorption occurred at pH = 6, temperature = 25 °C, 60 minutes contact time, and 0.6 g·L−1 adsorbent dose. Investigation of equilibrium isotherms showed that the isotherm fitted the Freundlich model with a correlation coefficient of R2 = 0.9689. The pseudo second-order model with the larger correlation coefficient had a greater fitness against experimental data in the kinetic studies. Thermodynamic parameters such as Gibbs free energy, enthalpy, and entropy were calculated, which indicated spontaneous, endothermic, and random processes, respectively. Given the good results of this project, nano-chitin can be suggested as a novel adsorbent which is highly capable of adsorbing hexavalent chromium from aqueous solutions.
Molecular and Epigenetic Basis of Extracellular Vesicles Cell
Repair Phenotypes in Targeted Organ-specific Regeneration
Authors: Fareez Ismail Muhamad , Seng Wu Yuan , Zaki Ramli Muhammad , Shafiq Aazmi , Izwan Ismail Mohamad 
Published: February 2021

:
Extracellular vesicles (EVs), which released by most of the cells, constitute a new system of cell-cell communication by transporting DNA, RNA and proteins, in various vesiclesnamely exosomes, apoptotic bodies, protein complexes, high-density lipid (HDL) microvesicles, among others.To ensure accurate regulation of somatic stem cell activity, EVs function as an independent metabolic unit mediating the metabolic homeostasis and pathophysiological of several diseases such as cardiovascular diseases, metabolic diseases, neurodegenerative diseases,immune diseases andcancer. Whist examining the EV biomolecules cargos and its microenvironments that lead to epigenetic alteration of the cell in tissue regeneration, studies have gainedfurther insights into the biogenesis of EVs and their potential roles in cell biology and pathogenicity. Due to its small size, non-virulence, flexibility and ability to cross biological barriers, EVs become promising therapeutic potentials in various diseases.In this review, we describe EV’s mechanism of action in intercellular communication and transfer of biological informationas well as some details about EV-induced epigenetic changes in recipient cells that causephenotypic alteration during tissue regeneration. We also highlight some of the therapeuticpotentials of EVs in organ-specific regeneration.
Antiproliferative Activity of Cissus quadrangularis L. Extract Against Human Cervical Cancer Cells: In Vitro and In Silico Analysis
Authors: Siddiqui Sahabjada , Zia Qamar , Abbas Mohd , Verma Sushma , Jafri Asif , Misra Deepika , Luqman Suaib , Ahamed Maqusood , Ahmad Mohd S. , Arshad Mohd 
Published: February 2021

Background:
Cervical cancer is the second leading cause of cancer in women, which necessitates safe
and potential therapeutic agents.

Objective:
This study was designed to investigate the antiproliferative effect of ethanolic extract of Cissus quadrangularis L. (CQ) against human cervical adenocarcinoma HeLa cell line and in silico analysis of selected active agents against apoptosis executioner enzyme caspase-3. Methods: Cell viability was analyzed in HeLa cells at different concentrations (25-300 μg/ml) of CQ extract. Reactive oxygen species (ROS) generation, cellular apoptosis, cell cycle analysis and caspases-3 activation were evaluated. In silico structure-based virtual screening analysis was carried out using AutoDock Vina and iGEMDOCK.

Results:
Cell viability was analyzed in HeLa cells at different concentrations (25-300 μg/ml) of CQ extract.
Reactive oxygen species (ROS) generation, cellular apoptosis, cell cycle analysis and caspases-3 activation were
evaluated. In silico, structure-based virtual screening analysis was carried out using AutoDock Vina and
iGEMDOCK.

Results:
Cell viability of HeLa cells was reduced significantly (p < 0.05) in a dose-dependent manner, however,
CQ extract showed non-toxic to normal kidney epithelial NRK-52E cells. CQ extract induced the intracellular
ROS level, nuclear condensation and reduced the mitochondrial membrane potential (MMP) with the induction
of annexin V-FITC positive cells. CQ extract arrested cells in G0/G1 and G2/M checkpoints and activated
caspase-3 activity significantly in HeLa cells. The molecular docking study showed a strong binding affinity of
CQ phytocomponents against the caspase-3 (PDB ID: 1GFW) protein of human apoptosis. PASS analyses of
selected active components using Lipinski’s Rule of five showed promising results. Further, drug-likeness and
toxicity assessment using OSIRIS Data Warrior V5.2.1 software exhibited the feasibility of phytocomponents as
drug candidates with no predicted toxicity.

Conclusion:
This study suggested that active constituents in CQ extract can be considered as potential
chemotherapeutic candidates in the management of cervical cancer.
Flavonoids as Prospective Aromatase Inhibitors in Breast Cancer Prevention/ Therapy
Authors: Seth Richa , Kushwaha Soni , Luqman Suaib , Meena Abha 
Published: February 2021

:
Flavonoids have been shown to target aromatase, suppressing the transformed cells' proliferation
and growth. Such experimental data further promoted the usage of flavonoids as an aromatase
inhibitor and helps prevent cancer, specifically breast and lung cancer. Conversely,
flavonoids have certain limitations like low absorption, potency, and some side effects in addition
to their tremendous advantages. The pharmacokinetics and toxicity of flavonoids are now being addressed
by using advanced nanotechnological approaches. This review discusses the comprehensive
aromatase signaling pathway in normal and cancer cells. It also draws attention to how do
flavonoids modulate aromatase signaling pathways. Also, different flavonoid groups inhibiting aromatase
activities are discussed and listed in the Table comprising flavonoids group, cancer type,
clinical trials, IC50, and the assay employed. Moreover, nanoparticles-mediated improvement in the
pharmacokinetics and toxicity issues of flavonoids in targeting aromatase are also deliberated. In
conclusion, flavonoids act as a potential anticancer agent via targeting aromatase. Besides, nanotechnological
approaches are useful in addressing the pharmacokinetics and toxicity of
flavonoids.
Epidemiology, Evolution, Transmission, and Therapeutics of COVID-19 Outbreak: An Update on the Status
Authors: Singh Karan , Mittal Amit Kumar , Gujral Akash 
Published: February 2021

:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an etiologic agent of
the respiratory disease in humans known as coronavirus disease 2019 (COVID-19). The beginning
of the outbreak of the disease was initially reported in Wuhan, Hubei Province, China, in December
2019, where patients felt SARS pneumonia-like symptoms with unknown etiology. Since then,
it has been noticed that SARS-CoV-2 positive patients show mild to severe upper respiratory illness.
SARS-CoV-2 belongs to the class of Coronavirus, which is known to make its transfer from
animals to humans and for the concerned virus; investigators have claimed its origin from bat coronavirus
at whole-genome level with a 96% sequence identity. The COVID-19 virus is extremely
contagious and communicable in nature and has spread across the world since its first outbreak documented
in Wuhan, China. On March 9, 2020, World Health Organization (WHO) declared it as a
pandemic, and within a month, it was already reported to have shown its presence in 213 countries
and territories or areas. As of Nov15, 2020, this novel virus has infected approximately. 53.7 million
people and caused 1.3 million mortalities worldwide. However, the mortality rate varied between
3-13% and was influenced by a number of factors, including the demographic distribution
and maybe age, comorbidities, etc. Diagnosis of the disease is a key component of controlling the
spread of the virus, and several techniques, including RT-PCR, ELISA, and sequencing-based approaches,
are in use. To cure COVID-19 patients, as of now, we do not have any safe and effective
treatment. Currently, there is no safe and effective drug for the disease. Furthermore, various pharmaceutical
industries are working on vaccine developments, which are in progress with the final
stages of clinical studies. Therapeutic options are also currently under investigation in various regions
of the world. However, there are various potential therapeutic targets to repurpose the present
antiviral therapy for developing potential interventions against SARS-CoV-2 infection. Boosting
the immune system can also help to prevent the spread of COVID-19 using various medications
and exercises. Here, this review summarizes and discusses the epidemiology, evolution, transmission,
and therapeutics scientific advancements related to this novel pandemic.
Estudio de color de la Facultad de Arquitectura Urbanismo y Artes de la Universidad Nacional de Ingeniería
Authors: Olazábal Furuya Lorena 
Published: February 2021

En el año 2017, se realizó el estudio de color del edificio de la Facultad de Arquitectura, Urbanismo y Artes (FAUA) con la finalidad de reconocer los diferentes estratos pictóricos subyacentes para poder conocer la paleta cromática empleada en el pintado de los inmuebles que corresponden a la FAUA a lo largo del tiempo. Esto ha permitido conocer los diversos usos y estilos cromáticos empleados, así como técnicas usadas y materiales empleados. Por otro lado, este tipo de prospección ha permitido definir el estado de conservación de ciertos estratos.
El uso de técnicas de prospección, como la elaboración de las calas estratigráficas permiten investigar y estudiar el bien inmueble como un documento histórico y a su vez dejar un vestigio sobre los cambios que se han suscitado a nivel estético y estilístico.
International Business and Country’s Culture Impact
Authors: Furxhi Gentisa 
Published: February 2021

International business is very important, nowadays. Businesses, now, compete and operate in an international market. Globalization has created new challenges for managers. Different countries have different cultures, and this make culture a challenge for businesses and managers who operate in international business. They have to pay more attention to the differences of countries cultures they operate with. Sometimes, differences may be seen as insignificant, but they can cause troubles if you don’t respect them. Culture’s differences may create misunderstandings, conflict, anger even stress in the workplace. People in different culture have different attitudes and behaviors. Organizations have to pay importance to differences in a) communication, b) attitudes c) workplace etiquette d) language.
Albania, after 90’, has been an attractive destination for foreign investors. Many investors came in Albania due to her strategic geography position, cheap labor price, informal market, etc.
In this paper we will analyze culture’s dimensions according to Hofstede model. Then, we will compare Albanian culture to Italian culture, because Italy is the country which has the majority of foreign companies in Albania.
Array-based Comparative Genomic Hybridization (aCGH) Reveals Chromosomal Aberrations in Chronic Obstructive Pulmonary Disease (COPD): A Preliminary Study
Authors: Trivedi Anjali , Ghosh Debabrata , Bade Geetanjali , Guleria Randeep , Sampath Meghashree , Talwar Anjana 
Published: February 2021

Chronic Obstructive Pulmonary Disease (COPD) is a complex disease with varying susceptibility. COPD development may be associated with copy number variation (CNV) in susceptible genomic regions. CNV also contributes to COPD heritability as these can cause changes in DNA fragment. CNVs in COPD smokers and COPD ex-smokers have not been examined so far. Thus, genome-wide array based comparative genomic hybridization (aCGH) was performed in COPD (n = 15) and control subjects (n = 13) to identify the vulnerable candidate genes for genetic susceptibility and CNVs in smoker (n = 6) and ex-smoker (n = 9) COPD and compare it with control subjects to identify the candidate genes potentially involved in the pathogenesis of COPD. Copy number gains and losses were detected in several chromosomal regions.
Chromosomal regions found to be consistently associated with both subgroups of COPD, as well as, of control group were: 2p11.2, 4q13.2, 8p23.1, 8p11.22, 12p13.31 and 14q32.33. Chromosomal regions associated with COPD were 11p15.5, 15q11.1-q11.2 and Xq28, which had several genes, (viz., CHECK2P2, HERC2P3, GOLGA6L6 and GOLGA8CP) which were associated with COPD smokers, while several other genes (viz., LICAM, LCA10, AVPR2, GDI1, HOTS and H19) were found to be associated with COPD ex-smokers. These loci and genes may be explored further for their potential use as predictive markers and better understanding of pathophysiology of COPD.
Proximal Triplane Tibial Fracture in a 6-Year-Old Girl
Authors: AlShaqsi Ziyad , Alhabsi Sara , Alnaabi Yumna , Almufargi Yaqoub 
Published: February 2021

Proximal tibial fractures are very rare. Our case is about a six-year-old girl presented with proximal tibial triplane fracture associated with proximal and distal fibula and distal tibial fractures, as a result of a fall of a cement wall on her right knee. A radiograph and computerized tomography (CT) scan were reported as Salter-Harris type III fracture. She was treated by an open reduction and internal fixation by a screw and Kirschner wires. She was followed up for 12 months and showed an excellent knee outcome and her knee range of motion was 10-130o. Anatomical reduction and stable fixation are necessary to prevent future pain, deformity and arthritis. The case demonstrates the efficacy of using an open reduction and internal fixation by a screw and Kirschner wires in treating children with triplane proximal tibial fracture. This type of fracture is not frequently seen and a right diagnosis leads to better management, which could prevent future complications
PENGARUH KEMAMPUAN TEKNIS AUDITOR TERHADAP KUALITAS INFORMASI LAPORAN KEUANGAN
Authors: Rahmawati Annisa , Indahingwati Asmara , GS Achmad Daengs 
Published: February 2021

ABSTRACT

This study intends to provide empirical evidence and a discussion of the influence of the auditor's technical capabilities built by the dimensions of knowledge, experience, and communication on the quality of information presented in the financial statements. This research is a quantitative research using explanatory method. The subjects of this study are public accounting firms located in East Java. The sample used in this study is the auditor who has carried out work at a public accounting firm in East Java with a length of service of at least two years. The type of data used in this study is primary data derived from questionnaires. The statistical analysis method used in this study is Structural Equation Modeling. From the data collection that has been done, the elaboration of this research shows that there is a significant positive impact between the auditor's technical ability on the quality of financial statement information. This result indicates that the better the technical capabilities possessed by the auditors concerned, the better the quality of the information presented in the audited financial statements.
Key words: audit; technical capabilities; financial statement information

ABSTRAK
Studi ini bermaksud untuk memberikan bukti empiris dan pembahasan tentang pengaruh kemampuan teknis auditor yang dibangun oleh dimensi pengetahuan, pengalaman dan komunikasi terhadap kualitas informasi yang tersaji dalam laporan keuangan. Penelitian ini merupakan penelitian kuantitatif dengan metode eksplanatori. Subyek dari penelitian ini adalah kantor akuntan public yang berlokasi di Jawa Timur. Sampel dalam penelitian ini adalah auditor yang telah melaksanakan pekerjaan pada kantor akuntan publik di Jawa Timur dengan lamanya masa kerja setidaknya dua tahun. Jenis data yang digunakan dalam penelitian ini adalah data primer yang berasal dari penyebaran angket. Metode analisa statistik yang digunakan dalam penelitian ini adalah Structural Equation Modelling. Dari pengumpulan data yang telah dilakukan, penjabaran dari penelitian ini menunjukkan adanya dampak positif signifikan antara kemampuan teknis auditor terhadap kualitas informasi laporan keuangan. Hal ini mengindikasikan bahwa semakin baik kemampuan teknis yang dimiliki oleh auditor yang bersangkutan maka akan semakin baik pula kualitas informasi yang tersaji dalam laporan keuangan auditan.
Kata kunci : audit kemampuan teknis; informasi laporan keuangan
Pengembangan Bahan Ajar Materi Trigonometri Berbantuan Software iMindMap pada Siswa SMA
Authors: Yunian Putra Rizki Wahyu , Anggraini Rully 
Published: February 2021

The purpose of this study is to find out how to develop teaching material trigonometric material aided iMindMap software. This type of research is research and development (R D). Sampling was done at SMAN 2 Negeri Katon Pesawaran. The results of the assessment are: the expert assessment of the material giving a score of 85,000% is categorized as highly feasible, the design expert scores 87,500% rating are categorized as highly feasible, and the media expert gives the scoring score of 79.167% categorized as feasible In small group trials, an average of 3.612 was obtained with very decent category. Then a large group trial obtained an average of 3,631 with very decent category. It can be concluded that the iMindMap software-triggered Trigonometry software module is categorized as very feasible and interesting to use in high school equivalent learning on Trigonometry material.
STRATEGIES FOR INCREASING THE PERFORMANCE OF EMPLOYEES IN. BANK RAKYAT INDONESIA (PERSERO) TBK UNIT BULUMARIO PASANGKAYU CITY
Authors: Arfah Muhammad 
Published: February 2021

The background of this purchasing problem is taken from the presence od employees who are not in accordance with existing abilities or slills so that they do not work and are delayed in a job. The type of research used is descriptive qualitative in which the authors describe the results describe the results of observations and direct interviews with the head of the bullumary unit and employees at PT. Bank Rakyat Indonesia (Persero) Tbk Bulumario Unit Pasangkayu City. Wring the final project is the result of writing done in june to july 2020. Research as outlined in this thesis aims to determine the strategy for developing employee performance in PT. Bank Rakyat Indonesia (Persero) Tbk Bulumario Unit Pasangkayu City. The results showed that the strategy for developing employee performance at PT. Bank Rakyat Indonesia (Persero) Tbk. Bulumario Unit In Pasangkayu City consists of 1. Improving discipline 2.Conducting training 3.Career path 4.Providing benefits to amployee 5.Maintaining good relations between employees.