bluuebunny/crossref_metadata_2025_split huggingface dataset:
The frequency and relationship of osteoporosis and vitamin D deficiency in the female geriatric population in Central Anatolia
Authors: YILDIRIM Tekin 
Published: April 2021

Bacground / Aims: The frequency of osteoporosis increases with age and is an important cause of mortality and morbidity due to hip fractures. The aim of our study is to determine the frequency of osteoporosis and vitamin D deficiency in female geriatric population and to investigate the relationship of vertebral and femur bone mineral densities (BMD) with vitamin D level in this population.
Material and Method: The study included 457 women aged 65 years and older. Vertebra and femur bone mineral densities (BMD) and serum 25-hydroxy vitamin D3 (25 (OH) D3) levels were measured.
Results: The mean age was found to be 72.4 ± 5.7 years. The mean L1-L4 and Femur neck BMD values in the participants were -2.74 ± 0.77, -2.31 ± 0.95 respectively, and the rate of osteoporosis was 72.2% (n = 330). There was no statistically significant difference between age groups in respect to frequency of osteaporosis (p = 0.58). Weak negative correlation was found between femur neck BMD value and age (r = -0.26, p
A gépesített háború elméletének nyugat-európai teoretikusai a két világháború között
Authors: Harka Ödön 
Published: April 2021

Eimannsberger tüzérségi tábornok osztotta a szovjet katonai teoretikusok mély hadműveletre vonatkozó elképzeléseit, azonban a hangsúlyt a harckocsik tömeges alkalmazására helyezte. Végkövetkeztetése az volt, hogy a (támadó) harckocsik nem kerülhetnek többé védtelen arcvonalakkal szembe, a védelem alapját a páncélelhárító fegyverek képezik. Guderian tábornok a harckocsifegyvernem feladataként határozta meg azt, hogy azok az alkalmazásuk szempontjából megfelelő sávban az ellenség előkészített védelmére csapást mérjenek, támaszkodva a meglepetés erejére. Elfogadva a jelen cikk első részében már részletesen körülírt, John Frederick Charles Fuller által kidolgozott megközelítést, de Gaulle alezredes Franciaországot csak abban az esetben látta megvédhetőnek egy meglepetésszerű német támadással szemben, amennyiben rendelkezik egy hivatásos katonákból álló, gépesített hadsereggel.
PEMBUATAN BASIS DATA WARGA DAN PELATIHAN KETERAMPILAN SISTEM INFORMASI BAGI KADER POSYANDU DAN POSWINDU KELURAHAN KALIMULYA DEPOK
Authors: Arnaldy Defiana , Neforawati Indri , Waluyo Yoyok Sabar 
Published: April 2021

Politeknik Negeri Jakarta sebagai lembaga pendidikan tinggi memiliki 3 (tiga) tugas besar, yaitu pendidikan, penelitian dan pengabdian masyarakat. Poin ketiga yakni pengabdian masyarakat merupakan bentuk kepedulian kalangan akademisi terhadap permasalahan yang terjadi di masyarakat. Kegiatan ini merupakan sarana untuk mengimplementasikan ilmu pengetahuan dan teknologi di lingkungan masyarakat. Politeknik Negeri Jakarta telah melakukan kerjasama dengan Pemerintahan Kota Depok dalam program Smart City yang menjadi program pemerintah Kota Depok. Kendala yang terjadi dalam mendukung program Smart City diantaranya adalah keterbatasan sumber daya khususnya kader posyandu dan poswindu. Selain itu masih konvensionalnya teknik pemasukan data-data warga dan sinkronisasi terhadap data di puskesmas. Pengabdian masyarakat yang dilaksanakan di Kelurahan Kalimulya Kecamatan Cilodong merupakan sebuah kegiatan yang menjadi sarana implementasi untuk peningkatan kemampuan keterampilan kader-kader posyandu dan poswindu dalam hal system informasi dan ketersediaan sebuah server basis data warga. Hasil yang diharapkan dalam kegiatan ini berupa meningkatnya keterampilan penggunaan komputer para kader dan tersedianya server basis data warga.
PEMBUATAN ALAT CUTTING HAND PRESS PADA KEMASAN MAKANAN RINGAN PRODUK UKM DI KOTA SERANG
Authors: Muryeti Muryeti , Sari Novi Purnama , Prastiwinarti Wiwi , Imam Saeful , Ningtyas Rina 
Published: April 2021

Kemasan menjadi faktor penting dalam meningkatkan nilai jual produk, selain itu kemasan berfungsi untuk melindungi produk, media promosi, menjadi identitas suatu produk, memperpanjang umur simpan produk, memudahkan dalam pendistribusian dan pemasaran produk, serta memenuhi kebutuhan dan kepuasan konsumen. Kota Serang merupakan salah satu target tempat wisata yang banyak dikunjungi wisatawan saat liburan. Hal ini menunjang perkembangan kuliner dan produk olahan hasil UKM di kota Serang untuk dijadikan produk oleh-oleh. Secara geografis, kota serang berada tidak jauh dari pesisir pantai utara sehingga banyak sumber daya hasil perikanan dan kelautan. Salah satu produk olahan hasil perikanan yang belum dikemas secara menarik adalah bakso goreng (makanan ringan yang berbahan dasar dari ikan). Bakso goreng sudah cukup dikenal oleh warga Serang, sebagai cemilan khas kota Serang. Namun aplikasi kemasan yang masih sangat minimalis menyebabkan produk ini tidak begitu dikenal oleh masyarakat luar daerah. Berdasarkan permasalahan kemasan tersebut, maka diperlukan suatu pengembangan alat kemasan efesien yang dapat diaplikasikan sehingga membantu UKM di daerah Serang untuk membuat kemasan secara mandiri. Program kerjanya mencakup perancangan dan pembuatan mesin produksi cetak alat cutting hand press dan, pelatihan serta pendampingan dalam penggunaan alat tersebut. Dengan adasnya alat cutting hand press sebagai mesin produksi cetak kemasan sekunder ini bisa membantu UKM Bakso Ikan Laksana meningkatkan kualitas dan nilai jual dari bakso goreng tersebut. Metode untuk melakukan program IPTEK bagi masyarakat ini adalah : tahap persiapan dengan melakukan survei ke daerah Serang dan membuat kerjasama dengan UKM setempat, tahap selanjutnya adalah merancang dan membuat alat cutting handpress sebagai mesin penunjang produksi kemasan yang sesuai dengan kebutuhan UKM dan ketersediaan bahan habis pakai yang bisa dibeli di kota Serang tersebut, setelah itu melakukan pendampingan pengoperasian alat cutting kemasan tersebut hingga UKM bisa melakukannya secara mandiri. Setelah dilakukan pelatihan dan pendampingan dalam pembuatan kemasan, UKM bakso Laksana, telah memiliki dan mampu membuat kemasan secara mandiri.
Pendampingan Pendirian Koperasi Simpan Pinjam dan Pembiayaan Syariah Koperasi Dana Bakti Sahabat
Authors: Hasanah Nurul , Rosa Silvia , Muchtasib Ach. Bakhrul 
Published: April 2021

Pengabdian masyarakat ini bertujuan sebagai sarana memberikan wawasan tentang koperasi syariah bagi Komunitas Bakti Sahabat Depok. Sekaligus memberikan pendampingan dan pemberdayaan ekonomi melalui pendirian koperasi simpan pinjam dan pembiayaan syariah. Disisi lain pengabdian masyarakat ini sebagai kontribusi nyata Politeknik Negeri Jakarta dalam hal ini program studi Keuangan dan Perbankan Syariah.Koperasi Simpan Pinjam dan Pembiayaan Syariah (KSPPS) yang merupakan lembaga keuangan mikro (LKM) yang mampu melayani kebutuhan masyarakat pelaku usaha mikro dan kecil. Lembaga ini memfasilitasi terbangunnya kondisi (sistem, metoda, teknik dan output) terwujudnya perimbangan kekayaan yang tidak hanya berada pada segolongan masyarakat. Secara simultan, KSPPS juga menjadi wadah sinergi masyarakat dan manciptakan kearifan lokal. Kearifan local yang dimaksud adalah bagaimana menyiapkan infrastruktur pembangunan berbasis partisipasi masyarakat lokal, yang tidak memiliki ketergantungan permanen pada bantuan, baik dari pemerintah maupun yang lain. Pelaksanaan KSPPS dilakukan dengan bersandar kepada aturan syariah dan aturan koperasi yang ada selama tidak bertentangan dengan hukum syariah. Kekuatan nilai-nilai spiritual dan sosial dari KSPPS ini menjadi kelebihan koperasi berbasis syariah dengan koperasi simpan pinjam konvensional. Dalam menjalankan program pengabdian ini akan dilakukan dengan melakukan pendekatan metode; persiapan, pembelajaran, dan pendirian koperasi simpan pinjam dan pembiayaan syariah.
Medical Physics Contributes to The Advancement in Medicine
Authors: Ng Kwan Hoong , Wong Jeannie Hsiu Ding , Yeong Chai Hong , Mohd Zin Hafiz , Jamal Noriah 
Published: April 2021

Medical physics is the application of physics principles and techniques in medicine. Medical physicists are actively applying their knowledge and skills in the prevention, diagnosis and treatment of diseases to improve health via research and clinical practice. In this paper, we present the roles of medical physicists in the three primary fields, namely, diagnostic imaging, radiotherapy and nuclear medicine. Medical physicists have been playing a crucial role in the advancement of new technologies that have revolutionised medicine today. This includes the continuous development of medical imaging and radiotherapy techniques since the discovery of X-ray and radioactivity. The last decade has seen tremendous development in the field that allows for better diagnosis and targeted treatment of various diseases. In the era of big data and artificial intelligence, while medical physicists continue to ensure that the application of the technologies in medicine is optimal and safe, it is paramount for the profession to evolve and be equipped with new skills to continue to contribute to the advancement of medicine.
Abordando percepciones erróneas sobre los conflictos de tierra y quinua: el caso de Bolivia
Authors: Garcia-Hernandez Ana 
Published: April 2021

El incremento de la popularidad de la quinua por sus caracterísiticas culinarias y nutricionales puede tener consecuencias inesperadas en los principales países productores. Mientras las comunidades productoras se podrían beneficiar del incremento de la demanda, también puede ocasionar deseos de controlar la tierra productiva, como indican numerosos artículos de prensa. Este estudio analiza si el incremento del precio de la quinua aumenta los conflictos de tierra en Bolivia, uno de los mayores productores de quinua del mundo. Comparamos la fluctuación del precio de este producto con el precio de otros productos exportados por el país: los minerales. No encontramos una relación significativa entre los precios de la quinoa y los conflictos por la tierra. Sin embargo, sí encontramos una asociación entre los precios de los minerales y los conflictos, consistente con los efectos rapacity y de coste de oportunidad descritos en la literatura. Mientras los precios de los minerales intensivos en mano de obra como la plata y el cobre están asociados con una reducción en los conflictos, las fluctuaciones no afectan al estaño y otras exportaciones intensivas en capital.
Perancangan Sistem Informasi Penilaian Siswa Berbasis Web Pada SMK Al-Ayaniah
Authors: Yulianjani Arsi , Rahayu Rais Nurlaila Suci , Andriana Viviet 
Published: April 2021

Teknologi Informasi saat ini berkembang sangat pesat. Di kantor, sekolah, perusahaan, pusat perbelanjaan, pusat pemerintahaan dan lain-lain, semuanya sudah serba komputer. Dengan adanya perkembangan teknologi informasi dapat membantu dan mempermudah manusia dalam melakukan pekerjaan, tugas, dankepentingannya. Demikian pula dengan SMK Al-Ayaniah, sekolah ini membutuhkan sistem pengolahan nilai yang terkomputerisasi, untuk membantu tugas guru dan wali kelas pada sekolah tersebut. Saat ini pengolahan data penilaian siswa-siswi SMK Al-Ayaniah masih semi komputer, yaitu masih terbatas pada penggunaan Microsoft Excel. Dalam satu kelas masing-masing siswa memiliki nilai yang berbeda-beda dan dicatat di buku, sehingga membutuhkan waktu yang sangat lama dalam pengerjaannya. Penelitian ini bertujuan menggunakan sistem berbasis web pada SMK Al-ayaniah untuk mempermudah penilaian. Untukpenganalisaan sistem digunakan metode SWOT (Strength, Weakness, Opportunities, Threats) dan untuk perancangan modelnya digunakan metode UML (Unified Modelling Language) untuk Bahasa pemrogramannya menggunakan PHP yang menggunakan aplikasi Sublime serta dalam pembuatan databasenya menggunakan MySQL. Dan untuk pengujian hasil rancangan digunakan Black Box testing. Dengan adanya sistem pengolahan nilai secara terkomputerisasi dapat membantu guru dan wali kelas dalam menginput dan mengolah nilai siswa dan siswi SMK Al-ayaniah lebih efektif dan efisien.
Kata Kata Kunci : Sistem, nilai , siswa
Tieteenalan rajat ja niiden ylittäminen
Authors: Isopahkala-Bouret Ulpukka 
Published: April 2021

Tieteenalojen rajojen ja identiteetin määrittely on jatkuva prosessi. Siihen eivät riitä tutkimuskohde
ja alan vakiintuneet menetelmät, ei edes ansiokas historia. Tieteenala pysyy elävänä ainoastaan, jos sen
ympärillä on vahva tiedeyhteisö, joka synnyttää uutta tutkimusta, kokee yhteenkuuluvuutta ja on valmis
puolustamaan alansa olemassaolon oikeutusta.
Implementing Action Research in a Teacher Preparation Program: Opportunities and Limitations
Authors: L. Black Glenda 
Published: April 2021

Action research has the potential to reconstruct schools into professional learning communities that are able to identify educational issues and develop appropriate solutions for 21st century learning. Increasingly, teacher education programs are providing action research experiences to encourage analytical thinking and problem-solving skills (Darling-Hammond, 2009, 2012). The purpose of this study was to critically examine the experiences of the teacher educator and teacher candidates involved in the implementation of an action research component over four years in a revised consecutive initial teacher preparation program. A case study design using action research methodology was used in the research, which provided the tools to explore a complex phenomenon within its context: the implementation of an action research assignment in a core course in a teacher preparation program. The perceptions of the faculty teaching the course and the teacher candidates (n=544) in each of the four years provided insight into challenges, benefits, and lessons learned. The discussion centers on the implementation of action research in a compulsory course in a teacher education program; identifying opportunities and limitations settled into four main categories: structural incongruence, reflection, growth, and recommendations.
BMSC-Derived Small Extracellular Vesicles Induce Cartilage Reconstruction of Temporomandibular Joint Osteoarthritis via Autotaxin–YAP Signaling Axis
Authors: Wang Yingnan , Zhao Miaomiao , Li Wen , Yang Yuzhi , Zhang Zhenliang , Ma Ruijie , Wu Mengjie 
Published: April 2021

Background: Temporomandibular joint osteoarthritis (TMJOA) seriously affects the health of patients, and the current treatments are invasive and only used for advanced cases. Bone marrow mesenchymal stem cell (BMSC)-derived small extracellular vesicles (BMSC-sEVs) may represent a safer and more effective treatment, but their role in TMJOA has not been elucidated. This study attempted to analyze the cartilage reconstruction effect of BMSC-sEVs on TMJOA and the mechanism underlying this effect.Methods: BMSC-sEVs were isolated and purified by microfiltration and ultrafiltration and were subsequently characterized by nanoparticle tracking analysis, electron microscopy, and immunoblotting. TMJOA models were established in vivo and in vitro, and hematoxylin–eosin staining, immunohistochemistry, and histological scoring were performed to analyze the histological changes in TMJOA cartilage tissues treated with BMSC-sEVs. The proliferation, migratory capacity, and cell cycle distribution of TMJOA cartilage cells treated with BMSC-sEVs were detected. Furthermore, the related mechanisms were studied by bioinformatic analysis, immunoblotting, and quantitative PCR, and they were further analyzed by knockdown and inhibitor techniques.Results: The acquisition and identification of BMSC-sEVs were efficient and satisfactory. Compared with the osteoarthritis (OA) group, the condylar tissue of the OA group treated with BMSC-sEV (OAsEV) showed an increase in cartilage lacuna and hypertrophic cartilage cells in the deep area of the bone under the cartilage. Significantly upregulated expression of proliferating cell nuclear antigen and cartilage-forming factors and downregulated expression of cartilage inflammation-related factors in OAsEV were observed. In addition, we found higher rates of cell proliferation and migratory activity and alleviated G1 stagnation of the cell cycle of OAsEV. Autotaxin was found in the BMSC-sEVs, and key factors of the Hippo pathway, Yes-associated protein (YAP), phosphorylated Yes-associated protein (p-YAP), etc. were upregulated in the OAsEV group. Treatment with BMSC-sEVs after autotaxin knockdown or inhibition no longer resulted in expression changes in cartilage-forming and inflammation-related factors and key factors of the Hippo pathway.Conclusions: These results suggest that the autotaxin–YAP signaling axis plays an important role in the mechanism by which BMSC-sEVs promote cartilage reconstruction in TMJOA, which may provide guidance regarding their therapeutic applications as early and minimally invasive therapies for TMJOA, and provide insight into the internal mechanisms of TMJOA.
Deciphering Gut Microbiota Dysbiosis and Corresponding Genetic and Metabolic Dysregulation in Psoriasis Patients Using Metagenomics Sequencing
Authors: Xiao Shiju , Zhang Guangzhong , Jiang Chunyan , Liu Xin , Wang Xiaoxu , Li Yafan , Cheng Meijiao , Lv Hongpeng , Xian Fuyang , Guo Xinwei , Tan Yong 
Published: April 2021

BackgroundIncreasing evidence has shown that alterations in the intestinal microbiota play an important role in the pathogenesis of psoriasis. The existing relevant studies focus on 16S rRNA gene sequencing, but in-depth research on gene functions and comprehensive identification of microbiota is lacking.ObjectivesTo comprehensively identify characteristic gut microbial compositions, genetic functions and relative metabolites of patients with psoriasis and to reveal the potential pathogenesis of psoriasis.MethodsDNA was extracted from the faecal microbiota of 30 psoriatic patients and 15 healthy subjects, and metagenomics sequencing and bioinformatic analyses were performed. The Kyoto Encyclopedia of Genes and Genomes (KEGG) database, cluster of orthologous groups (COG) annotations, and metabolic analyses were used to indicate relative target genes and pathways to reveal the pathogenesis of psoriasis.ResultsCompared with healthy individuals, the gut microbiota of psoriasis patients displayed an alteration in microbial taxa distribution, but no significant difference in microbial diversity. A distinct gut microbial composition in patients with psoriasis was observed, with an increased abundance of the phyla Firmicutes, Actinobacteria and Verrucomicrobia and genera Faecalibacterium, Bacteroides, Bifidobacterium, Megamonas and Roseburia and a decreased abundance of the phyla Bacteroidetes, Euryarchaeota and Proteobacteria and genera Prevotella, Alistipes, and Eubacterium. A total of 134 COGs were predicted with functional analysis, and 15 KEGG pathways, including lipopolysaccharide (LPS) biosynthesis, WNT signaling, apoptosis, bacterial secretion system, and phosphotransferase system, were significantly enriched in psoriasis patients. Five metabolites, hydrogen sulfide (H2S), isovalerate, isobutyrate, hyaluronan and hemicellulose, were significantly dysregulated in the psoriatic cohort. The dysbiosis of gut microbiota, enriched pathways and dysregulated metabolites are relevant to immune and inflammatory response, apoptosis, the vascular endothelial growth factor (VEGF) signaling pathway, gut-brain axis and brain-skin axis that play important roles in the pathogenesis of psoriasis.ConclusionsA clear dysbiosis was displayed in the gut microbiota profile, genetic functions and relative metabolites of psoriasis patients. This study is beneficial for further understanding the inflammatory pathogenesis of psoriasis and could be used to develop microbiome-based predictions and therapeutic approaches.
Bariatric Surgery: Consequences on Functional Capacities in Patients With Obesity
Authors: Reinmann Aline , Gafner Simone Chantal , Hilfiker Roger , Bruyneel Anne-Violette , Pataky Zoltan , Allet Lara 
Published: April 2021

IntroductionBariatric surgery leads to loss of fat and fat-free mass (FFM). To preserve FFM it is recommended that weight loss interventions are accompanied by physical activity. However, it remains unknown if functional capacities spontaneously improve after a substantial weight loss. Study’s aim was to assess the effect of bariatric surgery on strength, functional capacities and quality of life of participants with a body mass index (BMI) ≥ 35 kg/m2.MethodAnthropometric parameters (weight, BMI, waist circumference), physical functions (quadriceps strength, walking capacity, spatio-temporal gait parameters, dynamic balance, lower limb power) and quality of life were assessed before and at three months after the bariatric surgery in 33 individuals who did not follow any physical activity program.ResultsThe anthropometric parameters, quality of life and three functional abilities (walking capacity, normal gait speed and lower limb power) improved significantly three months post-surgery. In contrast, fast gait speed, absolute strength, normalized strength, and dynamic balance did not improve.DiscussionA massive weight loss should be accompanied by an exercise program aiming to maintain FFM and to enhance muscle strength and balance. Such a program might also enhance functional capacities and help to sustain the weight loss over time.
A Glycolysis-Based Long Non-coding RNA Signature Accurately Predicts Prognosis in Renal Carcinoma Patients
Authors: Cao Honghao , Tong Hang , Zhu Junlong , Xie Chenchen , Qin Zijia , Li Tinghao , Liu Xudong , He Weiyang 
Published: April 2021

BackgroundThe prognosis of renal cell carcinoma (RCC) varies greatly among different risk groups, and the traditional indicators have limited effect in the identification of risk grade in patients with RCC. The purpose of our study is to explore a glycolysis-based long non-coding RNAs (lncRNAs) signature and verify its potential clinical significance in prognostic prediction of RCC patients.MethodsIn this study, RNA data and clinical information were downloaded from The Cancer Genome Atlas (TCGA) database. Univariate and multivariate cox regression displayed six significantly related lncRNAs (AC124854.1, AC078778.1, EMX2OS, DLGAP1-AS2, AC084876.1, and AC026401.3) which were utilized in construction of risk score by a formula. The accuracy of risk score was verified by a series of statistical methods such as receiver operating characteristic (ROC) curves, nomogram and Kaplan-Meier curves. Its potential clinical significance was excavated by gene enrichment analysis.ResultsKaplan-Meier curves and ROC curves showed reliability of the risk score to predict the prognosis of RCC patients. Stratification analysis indicated that the risk score was independent predictor compare to other traditional clinical parameters. The clinical nomogram showed highly rigorous with index of 0.73 and precisely predicted 1-, 3-, and 5-year survival time of RCC patients. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene set enrichment analysis (GSEA) depicted the top ten correlated pathways in both high-risk group and low-risk group. There are 6 lncRNAs and 25 related mRNAs including 36 lncRNA-mRNA links in lncRNA-mRNA co-expression network.ConclusionThis research demonstrated that glycolysis-based lncRNAs possessed an important value in survival prediction of RCC patients, which would be a potential target for future treatment.