bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain Tumor Detection and Classification by Hybrid CNN-DWA Model Using MR Images
Authors: El Kader Isselmou Abd , Xu Guizhi , Shuai Zhang , Saminu Sani 
Published: February 2021

Objective:
Medical image processing is an exciting research area. In this paper, we proposed
new brain tumor detection and classification model using MR brain images to help the doctors
in early detection and classification of the brain tumor with high performance and best accuracy.

Materials:
The model was trained and validated using five databases, including BRATS2012,
BRATS2013, BRATS2014, BRATS2015, and ISLES-SISS 2015.

Methods:
The advantage of the hybrid model proposed is its novelty that is used for the first time;
our new method is based on a hybrid deep convolution neural network and deep watershed auto-encoder
(CNN-DWA) model. The method consists of six phases, first phase is input MR images, second
phase is preprocessing using filter and morphology operation, third phase is matrix that represents
MR brain images, fourth is applying the hybrid CNN-DWA, fifth is brain tumor classification,
and detection, while sixth phase is the performance of the model using five values.

Results:
The novelty of our hybrid CNN-DWA model showed the best results and high performance
with accuracy around 98% and loss validation 0, 1. Hybrid model can classify and detect
the tumor clearly using MR images; comparing with other models like CNN, DNN, and DWA, we
discover that the proposed model performs better than the above-mentioned models.

Conclusion:
Depending on the better performance of the proposed hybrid model, this helps in developing
computer-aided system for early detection of brain tumors and helps the doctors to diagnose
the patients better.
STAT3 Inhibitor Napabucasin Inhibits Tumor Growth and Cooperates with Proteasome Inhibition in Human Ovarian Cancer Cells
Authors: Liu Yao , Peng Xiaolin , Li Hui , Jiao Wenhui , Peng Xin , Shao Jingrong , Xu Yanglu , Wang Ran , Wang Wei , Kong Dexin 
Published: February 2021

Background:
Ovarian cancer is a disease with the highest mortality in gynecologic malignancies.
Activation of STAT3 pathway is well known to be associated with tumor progression
and metastasis in a number of cancers, including ovarian cancer. Therefore, STAT3 may be an ideal
target for ovarian cancer treatment.

Objective:
The present study aims to determine the antitumor activity of STAT3 inhibitor Napabucasin
as a single agent or in combination with proteasome inhibitor MG-132 in ovarian cancer
cells.

Methods:
MTT was performed to determine the anti-proliferative effect of Napabucasin on ovarian
cancer SKOV-3 cells. The involved anti-tumor mechanism was explored by flow cytometry, qRTPCR
and western blot. MDC staining and tandem mRFP-GFP-LC3 fluorescence microscopy were
used to analyze the autophagy-inducing capability of Napabucasin with or without MG-132. The
combinational anticancer effect of Napabucasin and MG-132 was evaluated according to Chou and
Talalay’s method (1984).

Results:
Napabucasin showed obvious tumor-inhibitory effects against SKOV-3 cells. Treatment
by Napabucasin arrested cell cycle progression in G2/M phase. Mechanistically, elevated expression
of p21 may contribute to the blockade of the cell cycle. Moreover, we demonstrated that Napabucasin
induced autophagy in SKOV-3 cells by using various assays, including MDC staining,
autophagic flux examination, and detection of the autophagy markers. In addition, a combination
of Napabucaisin with MG-132 exhibited a significant synergistic anti-proliferative effect, probably
by inducing apoptosis through a mitochondria-dependent pathway. The two compounds induced
pro-survival autophagies, and co-treatment with autophagy inhibiter might further enhance their antitumor
effects.

Conclusion:
Napabucasin alone or in combination with MG-132 might be promising treatment
strategy for ovarian cancer patients.
eHealth for Addressing Balance Disorders in the Elderly: Systematic Review
Authors: Gaspar Andréa G Martins , Lapão Luís Velez 
Published: February 2021

Background
The population is aging on a global scale, triggering vulnerability for chronic multimorbidity, balance disorders, and falls. Falls with injuries are the main cause of accidental death in the elderly population, representing a relevant public health problem. Balance disorder is a major risk factor for falling and represents one of the most frequent reasons for health care demand. The use of information and communication technologies to support distance healthcare (eHealth) represents an opportunity to improve the access and quality of health care services for the elderly. In recent years, several studies have addressed the potential of eHealth devices to assess the balance and risk of falling of elderly people. Remote rehabilitation has also been explored. However, the clinical applicability of these digital solutions for elderly people with balance disorders remains to be studied.

Objective
The aim of this review was to guide the clinical applicability of eHealth devices in providing the screening, assessment, and treatment of elderly people with balance disorders, but without neurological disease.

Methods
A systematic review was performed in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) statement. Data were obtained through searching the PubMed, Google Scholar, Embase, and SciELO databases. Only randomized controlled trials (RCTs) or quasiexperimental studies (QESs) published between January 2015 and December 2019 were included. The quality of the evidence to respond to the research question was assessed using Joanna Briggs Institute (JBI) Critical Appraisal for RCTs and the JBI Critical Appraisal Checklist for QESs. RCTs were assessed using the Cochrane risk of bias tool. We provide a narrative synthesis of the main outcomes from the included studies.

Results
Among 1030 unduplicated articles retrieved, 21 articles were included in this review. Twelve studies explored different technology devices to obtain data about balance and risk of falling. Nine studies focused on different types of balance exercise training. A wide range of clinical tests, functional scales, classifications of faller participants, sensor-based tasks, intervention protocols, and follow-up times were used. Only one study described the clinical conditions of the participants. Instrumental tests of the inner ear were neither used as the gold-standard test nor performed in pre and postrehabilitation assessments.

Conclusions
eHealth has potential for providing additional health care to elderly people with balance disorder and risk of falling. In the included literature, the heterogeneity of populations under study, methodologies, eHealth devices, and time of follow-up did not allow for clear comparison to guide proper clinical applicability. This suggests that more rigorous studies are needed.
The Implementation Science for Genomic Health Translation (INSIGHT) Study in Epilepsy: Protocol for a Learning Health Care System
Authors: Feofanova Elena Valeryevna , Zhang Guo-Qiang , Lhatoo Samden , Metcalf Ginger A , Boerwinkle Eric , Venner Eric 
Published: February 2021

Background
Genomic medicine is poised to improve care for common complex diseases such as epilepsy, but additional clinical informatics and implementation science research is needed for it to become a part of the standard of care. Epilepsy is an exemplary complex neurological disorder for which DNA diagnostics have shown to be advantageous for patient care.

Objective
We designed the Implementation Science for Genomic Health Translation (INSIGHT) study to leverage the fact that both the clinic and testing laboratory control the development and customization of their respective electronic health records and clinical reporting platforms. Through INSIGHT, we can rapidly prototype and benchmark novel approaches to incorporating clinical genomics into patient care. Of particular interest are clinical decision support tools that take advantage of domain knowledge from clinical genomics and can be rapidly adjusted based on feedback from clinicians.

Methods
Building on previously developed evidence and infrastructure components, our model includes the following: establishment of an intervention-ready genomic knowledge base for patient care, creation of a health informatics platform and linking it to a clinical genomics reporting system, and scaling and evaluation of INSIGHT following established implementation science principles.

Results
INSIGHT was approved by the Institutional Review Board at the University of Texas Health Science Center at Houston on May 15, 2020, and is designed as a 2-year proof-of-concept study beginning in December 2021. By design, 120 patients from the Texas Comprehensive Epilepsy Program are to be enrolled to test the INSIGHT workflow. Initial results are expected in the first half of 2023.

Conclusions
INSIGHT’s domain-specific, practical but generalizable approach may help catalyze a pathway to accelerate translation of genomic knowledge into impactful interventions in patient care.

International Registered Report Identifier (IRRID)
PRR1-10.2196/25576
Evaluación in vitro de la actividad antihemolítica de extractos acuosos (Camellia sinensis, Hibiscus sabdariffa Linn), bajo un diseño factorial 2x5
Authors: Pacheco Coello Franklin , Pinto-Catari Ibis , Ramirez-Azuaje Doralys , Orosco-Vargas Corymar , Peraza-Marrero María 
Published: February 2021

Introducción: el uso y el estudio de extractos obtenidos de material vegetal se ha incrementado a nivel mundial gracias a sus diversas propiedades bilógicas, como antimicrobiana, anticancerígena, antiinflamatoria y una muy poca estudiada, la antihemolítica.
Objetivo: la investigación tuvo como propósito caracterizar y evaluar la actividad antihemolítica de dos extractos acuosos obtenidos de C. sinensis e H. sabdariffa.
Material y métodos: para la obtención de los extractos se utilizó hojas de té verde orgánico y cálices deshidratados. Posterior a esto se evaluó la actividad antihemolítica con una suspensión de glóbulos rojos colocando alícuotas de cada extracto a distintas concentraciones en presencia de peróxido de hidrógeno (H2O2).
Resultados: se observó inhibición de la hemólisis en ambos extractos con una mayor actividad antihemolítica en el extracto de C. sinensis (p<0,05).
Conclusiones: la concentración de compuestos bioactivos presentes en los extractos favorece y contribuye con los sistemas propios de la célula encargados de eliminar moléculas que afectan el balance redox.
Analisis Bentuk, Makna dan Fungsi Lagu Rura Silindung Aransemen Erizon Rasin Koto Karya Guru Nahum Situmorang
Authors: Pasaribu Dedi Saputra , Sinaga Theodora 
Published: February 2021

Penelitian ini bertujuan untuk mengetahui bentuk, makna, dan fungsi lagu Rura Silindung aransemen Erizon Rasin Koto. Penelitian ini bersifat deskriptif kualitatif. Hasil penelitian membuktikan bahwa bentuk lagu Rura Silindung memiliki 6 motif dengan penambahan coda pada bar 33-36, memiliki 4 frase yang terdiri dari dua frase pertanyaan dan 2 frase jawaban, lagu ini juga merupakan lagu dua bagian yang terdiri dari A (a-a’) dan B (b-b’). Melodi, harmoni, dan ritme memiliki gaya dan karakteristik musik Samba, namun tetap dikolaborasikan dengan intrumen musik etnis Batak Toba, sehingga kesan dan nilai tradisi dari musik Batak Toba masih terlihat jelas. Namun terdapat kekurangan pada aransemen ini yaitu pada melodi m1 yang mengalami ketidaksesuain dengan makna syairnya. Lagu Rura Silindung yang diaransemen oleh Erizon Rasin koto ini merupakan karya dari komponis besar yang berasal dari Tanah Batak yaitu Guru Nahum Situmorang. Lagu ini memiliki makna akan keindahan alam Lembah Silindung, mewakili hati dan kehidupan masyarakat Silindung yang hidup damai, tentram dan saling berdampingan, lagu ini melambangkan ciri khas masyarakat Silindung. Lagu ini berfungsi sebagai lagu iringan pada berbagai acara adat, dan berfungsi sebagai lagu iringan pada pesta tahunan pada acara Panen Raya di Silindung, Tarutung.
Microspectrophotometry of Wood Grain and Color
Authors: Swatland Howard James 
Published: February 2021

A reflecting microscope spectrophotometer was used for the colorimetry of wood using CIE (Commission Internationale de l’Éclairage) chromaticity coordinates. A microscope scanning stage and scanning with optical fibers were used to detect grain patterns. Ten exotic woods with a fine grain structure were tested because they are highly valued in the manufacture of musical instruments and furniture, and they had a wide range in color and grain structure. With lateral illumination (45°) of samples and a large measuring aperture, the results were comparable to those that might be obtained with a commercial colorimeter detecting diffuse Lambertian reflectance. With vertical illumination and coaxial photometry in a microscope, Fresnel reflectance was dominant. The best predictor of CIE x with lateral illumination was reflectance at 400 nm (r = - 0.916, P < 0.0005) and the relationship persisted with vertical illumination (r = -0.67, P < 0.025). Scanning across woods at 520 nm with a microscope scanning stage, there were relationships of CIE x with scanning peak height (r = 0.75 P < 0.01). In scanning across 6 cm of wood with optical fibers, there was a relationship of the number of reflectance peaks (from wood grain between dark lines) with peak width (r = - 0.89, P < 0.0005). Woods with a fine grain had numerous small peaks while woods with a coarse grain had a few wide peaks. Thus, there is a connection between the color and grain pattern of wood.
Specjalne strefy ekonomiczne i strefy przemysłowe w kształtowaniu rozwoju gospodarczego regionów na przykładzie Polski i Czech
Authors: Wiedermann Krzysztof , Trojak Anita 
Published: February 2021

The aim of the present work is to show how the changing approach to special economic zones in Poland influenced the competitiveness of Polish regions, both on the internal and external scale. In the case of external conditioning, a comparative analysis of competitiveness of Polish regions against the Czech regions was conducted.In the examination of the internal- and external competitiveness conditions of particular Polish regions, an important element that shapes it is the existence of special economic zones. Their location positively affects the competitiveness of the given region, due to lower costs of functioning for the subjects active in the area. According to the original assumptions, creation of the zones was designed as a privilege for problem areas, e.g. characterized by high unemployment or low industrialization.Today’s solutions in this aspect considerably depart from the original assumptions of the idea of special zones, as – created when demanded by the investors – the zones include the most attractive regions. This has led to a situation when disproportion between peripheral and central areas of economic development is increasing. On the other hand, from the point of view of the state’s economic policy, Poland becomes more competitive. When observing the current inflow of crucial investments into the Central-European countries, we do not see situations typical of the 1990s and the first decade of the 21stcentury, when the most important investments were aimed at the Czech Republic or Slovakia (PeugeotCitroen-Toyota, VW, Kia or Hyundai), since the offers made by Poland to these investors usually concerned relatively unattractive locations, often peripheral, which could not compete with the areas of Prague, Bratislava, Ostrava, Trnava or Zilina.
EMPREENDEDORISMO SOCIAL E EMPREGABILIDADE: PERSPECTIVAS E POSSIBILIDADES PARA PROFISSIONAIS DE NÍVEL SUPERIOR
Authors: Pereira Tadeu Vaz Pinto , Leiria Sara Lustosa Abrahão 
Published: February 2021

Práticas empreendedoras e inovadoras são essenciais para um mercado cada vez mais competitivo e exigente. As Entidades Sem Fins Lucrativos (ESFL) estão cada vez mais buscando ações e projetos empreendedores que viabilizem seu trabalho, abram mais campos de atuação, assim como inove em seus projetos e ações. Tendo em vista que o principal fator de produção das ESFL é o trabalho de seus colaboradores, objetivo deste artigo é refletir acerca das particularidades do mercado de trabalho das ESFL de nível superior no Brasil. Observa-se, no período de 2006 a 2015, que que profissionais de nível superior em ESFL apresentam um salário médio inferior ao praticado na economia como um todo, bem como nas pessoas jurídicas EEP (setor privado tradicional), independente do porte de suas empresas. O artigo atenta-se, ainda, a questão de que o salário médio inferior é em função do tipo de pessoa jurídica (ESFL), ou a uma distorção de salários entre trabalhadores do sexo feminino, uma vez que as entidades ESFL são na sua maioria formado por trabalhadores do sexo feminino. Contudo, de maneira geral, observa-se uma dificuldade em se consolidar um mercado de trabalho de nível superior em ESFL, competitivo e atrativo em comparação a outras pessoas jurídicas.
Aspek Klinis dan Diagnosis Kandidiasis Vulvovaginal
Authors: Harminarti Nora 
Published: February 2021

Candidiasis vulvovaginal is an infection of the vaginal and vulva area caused by yeast Candida. The most causative species is Candida albicans. This fungus is commensal in the vagina but it can become a pathogen, causing the infection under certain conditions. Several conditions can be risk factors for this infection. Women are mostly getting infections, especially of productive age. Complaints experienced cause disturbances in the form of itching accompanied by abnormal vaginal discharge. The clinician can make diagnostics based on anamnesis, clinical and microscopic examination. This paper provides information about the causes, risk factors, clinical symptoms, and laboratory testing.
Pengelolaan Dana ZISWaf Masjid Pintar di Desa Kota Daro II, Kecamatan Rantau Panjang, Kabupaten Ogan Ilir
Authors: Yuliana Sa'adah , Rostartina Eka , Teguh Muhammad , Saleh Muhammad Syirod , Apriani Deassy 
Published: February 2021

Kegiatan pengabdian tentang pengelolaan dana ZISWaf masjid pintar bagi perangkat atau aparatur masjid bertujuan untuk memberikan pengetahuan tentang pengelolaan dana ZISWaf sehingga dapat mensejahterakan masyarakat desa, mengatur perekonomian masyarakat sekitar yang berlandaskan pada ajaran prinsip Islam serta dapat memperoleh pemahaman mengenai ZISWaf yakni Zakat, Infaq, Sadaqoh dan Wakaf baik dari praktek perhitungan ZISWaf maupun dari segi pemahaman dan pembagian tentang ZISWaf. Metode yang diterapkan dalam kegiatan ini adalah metode coaching dan bimbingan secara holistik step by step. Dari hasil yang dicapai terlihat bahwa pemahaman para peserta tentang ZISWaf masih belum sesuai yang diharapkan dikarenakan para peserta rata-rata masih terpaku dengan sistem manual dan ketidaktahuan mereka tentang pembagian ZISWaf baik jenis nya maupun perhitungannya. Diharapkan agar kedepanya pendampingan ini dirasakan manfaatnya untuk meningkatkan pemahaman mereka tentang ZISWaf.
Peran Financial Technology sebagai Alternatif Permodalan bagi UMKM di Desa Kerinjing, Kabupaten Ogan Ilir
Authors: Andaiyani Sri , Yunisvita Yunisvita , Tarmizi Nurlina 
Published: February 2021

Era revolusi industri 4.0 merupakan tantangan bagi suatu negara untuk mengubah model bisnis konvensional kedalam sistem berteknologi. Penggunaan teknologi inovatif di bidang keuangan (Financial Technology) menuntut model bisnis konvensional untuk segera berubah kearah moderat. FinTech muncul seiring perubahan gaya hidup masyarakat yang didominasi oleh pengguna teknologi informasi untuk menjadi penghubung antara sektor finansial dengan pengguna atau masyarakat umum. Indonesia merupakan pasar besar bagi FinTech seiring dengan meningkatnya mayoritas pengguna teknologi internet untuk transaksi bisnis.FinTech sangat berpotensi menjadi salah satu solusi untuk mengatasi masalah kekurangan permodalan bagi UMKM. Fintech diharapakan menjadi altenatif solusi bagi UMKM bertempat tinggal jauh dari pusat kota untuk memperoleh permodalan. Berdasarkan pada fenomena diatas, tim pengabdian kepada masyarakat Fakultas Ekonomi Universitas Sriwijaya, telah melakukan edukasi mengenai peran FinTech sebagai alternative permodalan bagi UMKM di Desa Kerinjing, Kabupaten Indralaya. Kegiatan pengabdian kepada masyarakat dilaksanakan pada hari Rabu tanggal 12 November 2019.Peserta terdiri dari 0 orang pelaku UMKM di Desa Kerinjing dan sekitarnya. Tim pelaksana memberikan materi terkait dengan apa yang dimaksud dengan financial technology, manfaat dari fintech dan dampak dari fintech. Peserta dapat membedakan fintech legal dan illegal.Fintech legal yang dimaksud adalah fintech yang terdaftar di Otoritas Jasa Keuangan (OJK). Sebagai evaluasi kegiatan, tim memberikan form kuisioner yang diisi oleh peserta. Berdasarkan hasil kuesioner, pemahaman peserta setelah diberikan edukasi Fintech telah mencapai 70 %.
Intención emprendedora en los productores de chile del estado de Aguascalientes: Perspectiva desde las relaciones de colaboración
Authors: Parga-Montoya Neftalí , Vega-Martínez Javier Eduardo , Miramontes-Acevedo Guillermo 
Published: February 2021

Las redes de colaboración son un tópico relevante para el desarrollo económico, social e individual de los emprendedores. Se tiene como base la teoría de los recursos y capacidades para analizar las redes que tienen los productores de chile con otros actores del sector. El estudio tiene como objetivo principal medir los efectos de las redes de colaboración, tanto empresariales como institucionales sobre las intenciones emprendedoras. Se realizó un estudio empírico con 94 agricultores ubicados en el estado de Aguascalientes, México. Las hipótesis planteadas se contrastaron a partir de regresiones multivariantes. Los resultados obtenidos más relevantes se centran en las redes institucionales como detonantes de la intención emprendedora, teniendo efectos diferentes entre sí al conjuntar la escolaridad y la experiencia en el modelo. De la misma manera, las contribuciones teóricas recaen en el desarrollode una perspectiva de la intención emprendedora sustentada en la formación académica con implicaciones importantes.