bluuebunny/crossref_metadata_2025_split huggingface dataset:
OUTCOME OF TREATING PEDIATRIC LANGERHANS HISTIOCYTOSIS WITH LCH III IN TERTIARY CENTER, SAUDI ARABIA
Authors: Almohammadi Abrar , Khalid Khalid , Shehadah Moussa , Baothman Abdullah 
Published: April 2021

Background: Langerhans cell histiocytosis (LCH) is a rare disease affects any age and any organ; its presentations and outcome vary from self-healing lesions to life-threatening disseminated disease. This study evaluated the outcome of treating children diagnosed with Langerhans cell histiocytosis (LCH) at Oncology Center, Saudi Arabia.
Methodology: Through a retrospective study design, the researchers reviewed the medical records and electronic files of all children (aged from 0-≤ 14 years) who had been diagnosed and treated for LCH at Princess Norah Oncology Center (PNOC), King Abdelaziz Medical City, Saudi Arabia, in the period from January 2000 to December 2019 (n=33).
Findings: Males constituted (66.7%), with remarkable dominance of Saudis (93.9%). The median age at diagnosis was 28 months (IQR=49 months); (42.4%) were diagnosed before reaching their second birthday. Fourteen patients (42.4%) had multisystem (MS-LCH) involvement, of which 13 patients with risk organ (RO) (+) and one patient without risk organ (RO) (-). Most of the patients received LCH III protocols. Reactivation occurred in 11 patients (33.3%), and two deaths (6.1%) occurred in cases with MS (RO) (+) progressive disease. The overall survival was 93.9%; with no statistically significant difference in event free survival observed between patients with multisystem compared to single system involvement.
Conclusion and recommendations: Excellent outcome of LCH is associated with single system involvement and worse outcome (reactivations, or morality) is determined by multi-organ involvement especially at younger age less than 24 months. Better understanding of pathophysiology and genetic molecular background could lead to a striking transformation to novel therapy that warrants a prospective clinical trial. A high mortality in patients with progressive disease demands an earlier aggressive salvage in such group. Prospective clinical trials are required for improved treatment strategies in these subgroups
THE TEST OF BACTERIAL CONTAMINATION ON MEATBALL PRODUCTS IN THE TRADITIONAL MARKET OF MARISA, POHUWATO
Authors: Asnita Kamumu  , Rita Amini Warastuti  , Agusrianto Yusuf  
Published: April 2021

ABSTRACT
Meatball is one of Indonesia's typical meat-based products. It is usually served at a high temperature, moreover, it contains high nutrient due to the high animal nutrient that is necessary for human growth. The current study aims to determine the test of bacterial contamination on meatball that are sold in the traditional market of Marisa, district of Pohuwato. Five meatball samples were taken from five different vendors, and the sample testing was done in the laboratory of the faculty of science, technology, and health on July 13th, 2020. The test included the total plate count microbial pathogens contamination and E. coli bacteria in the meatballs.
The data were analyzed descriptively and presented in a tabular to illustrate the total plate count of pathogen contamination and E. coli bacteria in the meatballs. According to SNI 01-3818-1995, the maximum total plate count (ALT) of colonies/g is 0.1x102, and for the E. coli bacteria, the AMP/g is <3.0.
As the results. It shows that the total microbes on the meatballs in the traditional markets of Marisa is ranged between 4.5x104 colonies/g to 2.3x105 colonies/g. It also shows that the meatballs still meet the requirement for the counts of microbial colonies, while the most probable number (AMP) of coliform bacteria is still high
DETERMINANTS RELATED TO LUNG TUBERCULOSIS IN THE WAY OFPUBLIC HOSPITAL ANUTAPURA
Authors: Erfan AR. Lainjong  
Published: April 2021

Pulmonary Tuberculosis (pulmonary TB) is an infectious airborne disease caused by the bacterium Mycobacterium tuberculosis, which affect the lower respiratory tract. Education level, smoking, income, and family history were known as risk factors for pulmonary TB. The purpose of this study was to determine the determinants associated with pulmonary TB in the outpatient department of Anutapura General Hospital, Palu.
This research was an analytical study with a cross-sectional design. The independent variables in this study were the level of education, smoking status, income, and family contact history, while the dependent variable was pulmonary TB. We enrolled 43 respondents with accidental sampling method. Data analysis using univariate and bivariate analysis.
The results showed that there was a relationship between education level and pulmonary TB (p = 0.024), smoking status and pulmonary TB (p = 0.004), income and pulmonary TB (p = 0.001), and family contact history with pulmonary TB (p = 0.001).There is a relationship between education level, smoking status, income, and family contact history with pulmonary TB. It is suggested to the health workers of RSU Anutapura Palu to increase understanding and knowledge of patients regarding the prevention and transmission of pulmonary TB disease.
Drying a Standing Teak Tree using a Solar Kiln Drying Method
Authors: PHONETIP Khamtan , BOUPHA Latsamy , PHANOUVONG Bounyu , SICHALUENE Oudone , KHAMMANIVONG Khanxay , BOUAPHAVONG Douangta 
Published: April 2021

Understanding the rate of drying of standing trees dried by using a solar kiln drying method could help in predicting the change of moisture content in the tree over a period of drying time. The purpose of this study was to observe the change of moisture content profile in a standing tree during drying. A standing Tectona grandis tree was selected for the experiment with a diameter at breast height of 29 cm in a mixed-species plantation. The tree was girdled with 20 cm width at 20cm above ground. For the experiment, the tree was wrapped in a transparent plastic sheet and a black plastic sheet was installed at the bottom with an angle of 39 °C facing Southwest to maximize solar radiation, with the method being modified from the solar kiln method, which is known as a greenhouse type, with 2 layers of plastic cover. The black and white sheets were placed on the inner side for insulation and for collecting heat from the sun’s radiation, while the outer layer was transparent, which allowed radiation to propagate unhindered in the black sheet. In this study, a sensor for temperature and relative humidity (DHT22) was attached inside the wrapped plastic and the data recorded every 6 min. The results showed that drying a standing teak tree from an initial average moisture content of 105 % to a constant point of 60 % took 80 days under the maximum of the collected temperature of 46 °C inside the wrapped plastic; this finding confirmed that the predicted model of recharge and discharge curve was likely accurate.
Role of Occupational Therapy in Facilitating Participation Among Caregivers of People With Parkinson’s Disease: A Systematic Review
Authors: Boone Anna E. , Henderson Whitney , Hunter Elizabeth G. 
Published: April 2021

Abstract
Importance: Caregivers play a critical role in facilitating the performance of people with Parkinson’s disease (PD). Knowledge on how occupational therapy practitioners can mitigate the negative effects of caregiving is needed to enable caregiver participation.
Objective: To explore the effectiveness of interventions within the scope of occupational therapy practice for caregivers of people with PD to facilitate or maintain their participation in the caregiver role.
Data Sources: We conducted a systematic review of the literature published in CINAHL, MEDLINE, PsycINFO, and OTseeker between 2011 and 2019. Article reference lists were also hand searched for additional articles.
Study Selection and Data Collection: Articles were screened and evaluated using the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines. The review was conducted in accordance with steps outlined by the American Occupational Therapy Association’s Evidence-Based Practice Project.
Findings: Six articles met the inclusion criteria. Interventions in each article were distinct, prohibiting theme development. Overall, the strength of evidence was low, and the risk of bias was high. None of the studies included in this review were obtained from the occupational therapy literature.
Conclusions and Relevance: Little evidence is available to support interventions within the scope of occupational therapy practice for caregivers of people with PD. Existing evidence suggests that interventions need to be flexible (e.g., in terms of time, cost, and delivery method) and tailored to the unique needs of this population.
What This Article Adds: There is a continued need to develop occupational therapy interventions that support participation in the caregiving role for caregivers of people with PD.
Occupational Therapy–Related Assessments for Adults With Intellectual Disability: A Scoping Review
Authors: Mahoney Wanda J. , Blaskowitz Meghan G. , Johnson Khalilah R. 
Published: April 2021

Abstract
Importance: Occupational therapy practitioners use structured assessment tools to gather information from adults with intellectual disability (ID) in order to develop the occupational profile, guide occupational therapy intervention, and assess change over time.
Objective: To identify occupational therapy–related tools in the peer-reviewed literature for use in practice with adults with ID.
Data Sources: Peer-reviewed literature published between January 2002 and January 2018 included in CINAHL, PsycINFO, PubMed, and Scopus.
Study Selection and Data Collection: The review included articles that had information on occupational therapy–related assessment with adults 18 yr or older who had primary or co-occurring ID.
Findings: Fifty-eight articles identified 73 occupational therapy–related assessment tools.
Conclusions and Relevance: This scoping review identified a broad range of assessment tools in the occupational therapy domain that are appropriate for adults with ID, some of which may be unfamiliar to occupational therapy practitioners.
What This Article Adds: This scoping review provides occupational therapy practitioners with a summary of occupational therapy–related assessment tools for adults with ID and an assessment reference guide.
GRANITOS DE PEDRA DE GUARATIBA, RJ: VARIAÇÕES FACIOLÓGICAS E EVIDÊNCIAS DE ACUMULAÇÃO DE MEGACRISTAIS POR SEGREGAÇÃO MECÂNICA EM ZONAS DE ENCLAVES
Authors: ALMEIDA Soraya , NASCIMENTO Carlos Wagner Rodrigues do 
Published: April 2021

A Serra da Capoeira Grande e o Morro do Silvério, em Pedra de Guaratiba, constituem o prolongamento sudoeste do Maciço da Pedra Branca. A rocha dominante na região é um granito rosa com cristais de microclina tabular orientados na direção NE-SW. Variações faciológicas resultantes da irregularidade no tamanho de grãos, da razão fenocristais/matriz e da intensidade da lineação ocorrem em escala métrica a centimétrica e com contatos transicionais entre si. Enclaves de metassedimentos e de rochas ortoderivadas, com diferentes graus de assimilação, ocorrem ao longo de uma faixa linear NE-SW. Esses apresentam contornos lenticulares e orientação preferencial concordante com a direção dos megacristais de microclina e do bandamento ígneo. Dados de campo apontam para processos de segregação mecânica na formação dos subtipos, com granito equigranular, de granulação fina, como produto de segregação entre fenocristais e material intersticial. O arranjo espacial entre enclaves, granito equigranular e aglomerados de feldspato indicam terem os enclaves atuado como filtros retentores de fenocristais durante fluxo magmático. Concentrados de allanita ocorrem ao longo da zona enriquecida em enclaves, sugerindo a formação desse mineral por fluidos tardios, com mobilização de elementos terras favorecida pela maior permeabilidade da faixa.
ARQUITETURA E EVOLUÇÃO DEPOSICIONAL DA SUCESSÃO SEDIMENTAR PLEISTOCENO TARDIO-HOLOCENO (ÚLTIMOS ~20 Ka) DA BAÍA DE SEPETIBA (RJ)
Authors: REIS Antonio Tadeu dos , AMENDOLA Guilherme , DADALTO Tatiana Pinheiro , SILVA Cleverson Guizan , TARDIN POÇO Raiane , GUERRA Josefa Varela , MARTINS Virginia , CARDIA Renata Rebouças , GORINI Christian , RABINEAU Marina 
Published: April 2021

A baía de Sepetiba, localizada na costa oeste fluminense, consiste de um embaiamento onde predominam condições estuarinas com contato limitado ao oceano aberto, devido à presença da restinga da Marambaia - uma ilha-barreira de ~40 km de comprimento. O presente estudo visa o detalhamento da evolução estratigráfica do preenchimento sedimentar da baía, baseado na análise de ~ 800 km de linhas sísmicas de alta resolução, correlacionada a dados de datação de horizonte sísmico na plataforma continental (14C AMS) e de estágios de evolução da restinga da Marambaia (14C AMS/LOE). A integração dos resultados revelou a existência das unidades U2-U5 - uma sucessão sedimentar transgressiva e de mar alto de até ~30 m de espessura, que testemunha a implantação de um sistema estuarino aberto na região em direta conexão com o mar (deposição de U2), que evoluiu para condições estuarinas progressivamente mais isoladas (deposição das unidades U3 e U4) até atingir uma configuração de ambiente estuarino de baixa energia sem conexão direta com o mar (deposição da unidade U5), similar às condições do sistema deposicional atual. Os diferentes ambientes estuarinos, revelados pela fácies sísmicas das unidades U2-U5, estão diretamente correlacionados às diferentes fases de construção e/ou fechamento da restinga da Marambaia.
Palavras-chave: Deposição transgressiva; Paleosistema estuarino; Transgressão Pleistoceno Tardio-Holoceno.
QUANTIFICAÇÃO DA DEFORMAÇÃO EM MIGMATITOS METATEXITOS ESTROMÁTICOS E ROCHAS ASSOCIADAS DO COMPLEXO ATUBA, PORÇÃO LESTE DO ESTADO DO PARANÁ
Authors: BALDIN Michelangelo Tissi , SALAMUNI Eduardo , LAGOEIRO Leonardo Evangelista 
Published: April 2021

RESUMO – O Complexo Atuba aflora na porção leste do Estado do Paraná, segundo uma faixa alongada de direção NE-SW e compreende a parte sul do Cinturão Ribeira. Este trabalho tem como objetivo principal elucidar os processos deformacionais do Complexo Atuba. A investigação foi desenvolvida por meio de investigação de campo, petrografia e análise estrutural quantitativa e, complementa vários estudos tectônicos já realizados anteriormente. Os migmatitos metatexitos estromáticos possuem médio a alto grau metamórfico e são compostos por neossomas residuais tonalíticos intercalados com leucossomas graníticos ou granodioríticos-tonalíticos e melanossomas máficos. Muitas vezes podem ser classificados como pertencentes à série dos milonitos. Observam-se também anfibolitos, xistos, gnaisses granulíticos, diatexitos schollen, quartzitos e granitoides. Dois planos de foliação, ambos gerados por cisalhamento dúctil, foram identificados: o primeiro é caracterizado pela foliação Sn-1 associada à tectônica de cavalgamento (Dn-1) e o segundo pela foliação Sn produzido por tectônica transpressiva sinistral (Dn). Os resultados confirmam que a última fase foi acomodada pela partição da deformação. A quantificação da deformação foi desenvolvida por intermédio dos métodos de Fry, Polar e Rf/φ, com base na análise de cristais de quartzo e feldspatos em 26 lâminas delgadas. As amostras revelaram razões de deformação similares para todos os métodos utilizados nos planos XZ e YZ. Os elipsoides possuem forma oblata e correspondem ao campo do achatamento aparente.
Palavras-chave: análise estrutural, migmatitos, transpressão.
EVIDÊNCIAS DE MINGLING NA UNIDADE GENTILEZA, DOMÍNIO CANINDÉ, FAIXA DE DOBRAMENTOS SERGIPANA
Authors: ALMEIDA Cássio Brener Andrade , MACHADO Adriane , PASSOS Luiz Henrique 
Published: April 2021

Feições de mingling têm sido evidenciadas nas rochas da Unidade Gentileza do Domínio Canindé, parte setentrional da Faixa de Dobramentos Sergipana, NE do Brasil. O objetivo deste trabalho foi identificar e caracterizar a mineralogia, os aspectos texturais e as feições de mingling presentes nos afloramentos situados ao longo da SE-200, nas proximidades da cidade de Canindé de São Francisco (SE). As feições de mingling são resultantes da interação de um termo máfico (anfibolito - Unidade Gentileza) e félsico (metamonzogranito/metassienogranito - Granito Boa Esperança). As feições de mingling observadas nos afloramentos são estrutura tipo pillow, filtragem-prensagem e porções complexas com injeções félsicas. Os dados de geoquímica sugerem que os protólitos dos anfibolitos correspondem, em maioria, à andesitos basálticos e andesitos, de afinidade cálcio-alcalina. Os dados geoquímicos dos anfibolitos são compatíveis com magmas gerados em ambiente geotectônico do tipo intraplaca continental, possivelmente representado por um rifte continental, enquanto que o magma do Granito Boa Esperança teria sido gerado em ambiente de granitos de arco vulcânico.
STRUCTURAL, STRATIGRAPHIC AND METALLOGENETIC ASPECTS OF THE PARAGUAY FOLD AND THRUST BELT: IMPLICATIONS FOR GOLD MINERALIZATION AND COLLAGE OF THE GONDWANA
Authors: BARBOZA Elzio da Silva , GERALDES Mauro Cesar , PINHO Francisco Egídio Cavalcante , FERNANDES Carlos José , SILVA Carlos Humberto da 
Published: April 2021

ABSTRACT - Paraguay Belt occupies the western portion of the Tocantins Province, surrounding the Southeast of the Amazonian Craton and the eastern border of the Rio Apa Block, suggesting continuity with Tucavaca Belt in Bolivia. The rocks of the Paraguay belt were initially deposited in a glaciomarine environment in sites proximal to the cratonic area and deeper marine under the influence of turbidite flows in distal sites (Cuiabá Group, Bauxi and Puga Formation). The cap carbonates, thick limestone and dolostone succession of the Araras Group and siltstones and diamictites of the Serra Azul Formation related to Glaskiers glaciation overlay these diamictites (related to Marinoan glaciation). On the top there are terrigenous sediments of the Alto Paraguay Group, represented by sandstones of Raizama and claystones of Diamantino formations, respectively. The belt can be divided into three distinct structural zones: The Internal Domain is comprised of turbidite and glaciogenic sequences. Glaciogenic rocks on the base and carbonaceous and terrigenous sediments on the top occur in the External Domain. Horizontal platformal cover on the Amazonian Craton rocks are characterized by open folds. Structural studies allowed characterization of continuous deformational phases: the main deformational phase generated regional inverse folds with a NE-SW trend and fan geometry. Several regionally widespread lode-type gold deposits related to four types of the quartz veins were identified: type 1 is in concordance to bedding, type 2 is parallel to Sn, type 3 is parallel to Sn+2, and vertical Type 4 (Au-rich) is orthogonal to Sn. Late deformation developed in the Cuiabá region, recorded the closure of the ocean and the invertion where the hydrothermal fluids are the responsible for the orebodies formation.
Keywords: Paraguay Belt, Structural, Stratigraphy, Metalogenesis.
Amplification of Cord Blood-Derived Cytotoxic T Lymphocytes using HL-60 cell Derived Exosomes
Authors: Gong Xiangcui , Li Zhenghao , Wang HuanHuan , Li Dong , Ju Xiuli 
Published: April 2021

IntroductionDendritic cell (DCs) based cytotoxic T lymphocytes (CTLs) are commonly used in immunotherapy due to their specificity. The selection of appropriate cell origin and tumor antigen is the key point. The objective was to culture DCs and CTLs simultaneously from cord blood, and deliver antigen information using tumor derived exosomes.Material and methodsExosomes were collected from the human promyelocytic leukemia cell line HL-60 using ultracentrifugation. Prepared DCs from adherent cord blood mononuclear cells (MNCs) using SCF, GM-CSF, and IN-4. TNF-α and microRNA removed tumor-exosome were used to induce DCs maturation. DCs matured in the presence of HL-60 cell membrane protein extract or no antigen were set as control. CTLs was cultured from non-adherent MNCs by adding IFN-γ, IL-15, SCF, FLT-3L, anti-CD3, anti-CD28 and IL-2. The CTLs were analyzed by flow cytometry, cytotoxicity experiments and ELISA.ResultsDCs can be obtained from cord blood and express costimulatory molecules. After 15 days, the total number of the cells expanded 26.3 times, and more than 82% of the cells expressed CD3+CD8+ in the most amplified HL-60-Ex-DCs-CTL group. These CD3+CD8+ T cells generated by HL-60-Ex-DCs displayed specific cytotoxicity towards HL-60 and low lethality towards unrelated BALL-1 cells. ELISA results showed that the expressions of TNF-α and IFN-γ in HL-60-Ex-DCs or HL-60mPr-DCs activated CTLs were upregulated compared with the control group.ConclusionsCord blood CTLs generated by HL-60 derived exosome activated DCs displayed specific cytotoxicity towards HL-60 promyelocytic leukemia cells. Therefore cord blood and tumor derived exosomes provided a good source for adoptive immunotherapy.
UPAYA MENINGKATKAN HASIL BELAJAR PERSAMAAN DASAR AKUNTANSI MELALUI METODE KOOPERATIF TIPE THINK PAIR SHARE (TPS) DI KELAS XI IPS
Authors: Johanis Magdalena 
Published: April 2021

Penelitian ini menggunakan teknik sosiodrama pada layanan bimbingan konseling tentang etika pergaulan.
Tujuan dari penelitian ini adalah dengan teknik sosiodrama pada layanan bimbingan konseling peneliti ingin meningkatkan layanan bimbingan konseling etika pergaulan siswa kelas XII SMK Lembang.
Hasil penelitian menunjukan bahwa aktivitas siswa pada siklus 1 mendapat predikat C dengan nilai 17 dan siklus II mendapat predikat B dengan nilai 24, ketuntasan nilai pada siklus I mencapai 50 % dengan jumlah siswa yang tuntas 12 orang dari 24 siswa. Pada siklus II semua siswa kelas XII yang berjumlah 24 orang dinyatakan tuntas dan mencapai 100%. Peningkatan ini naik mencapai 50%. Berdasarkan hasil penelitian yang dilakukan maka disimpulkan bahwa dengan menggunakan teknik sosiodrama pada layanan bimbingan konseling etika pergaulan di kelas XII SMK Lembang dinyatakan tuntas dan tidak dilanjutkan pada penelitian ke siklus berikutnya.
PENERAPAN PEMBELAJARAN KOOPERATIF TIPE TAI (TEAM ASSISTED INDIVIDUALIZATION) PADA SISWA KELAS X SMK NEGERI 3 PROBOLINGGO
Authors: Winarto Bambang 
Published: April 2021

Tujuan yang ingin dicapai dalam penelitian ini adalah untuk mengkaji bagaimanakah penerapan pembelajaran kooperatif tipe TAI (Team Assisted Individualization), mengetahui keaktifan siswa dan mengetahui presentase ketuntasan belajar siswa pada materi sistem persamaan linier dua variabel siswa kelas X SMK Negeri 3 Probolinggo Tahun Pelajaran 2018/2019.
Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kualitatif. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK).
Kesimpulan yang dapat diambil dalam penelitian ini Penerapan pembelajaran kooperatif Teams Asssisted Individualization (TAI) dengan Authentic Assesment membuat siswa menjadi aktif dalam proses pembelajaran. Hal ini dapat ditunjukkan pada hasil analisis data observasi siswa. Persentase aktivitas siswa untuk mental activities, writing activities, oral activities, visual activities, listening activities, dan tidak aktif pada siklus I masing-masing sebesar 33,1%, 36,65%, 33,27%, 31,58%, 25,16%, dan 20,27% pada siklus II sebesar 37,83%, 40,54%, 36,14%, 34,45%, 28,37%, 19,42%. Pada aktivitas kegiatan kelompok persentase keaktifan untuk oral activities, visual activities dan tidak aktif untuk siklus I masing-masing sebesar 48,43%, 42,96%, 23,43% sedangkan pada siklus II sebesar 53,9%, 46,87%, 17,18%. Persentase ketuntasan belajar secara klasikal setelah penerapan model pembelajaran TAI dengan Authentic Assessment pada materi system persamaan linier dua variable siswa kelas X sebesar 91,89% untuk siklus I dan 94,59% untuk siklus II.