bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiological study on COVID-19 virus transmission network in northeast China
Authors: Feng Tianyu , Sun Helin , Sun Mengzi , Wang Yudan , Zhang He , Sun Chong , Li Kexin , Wang Yingshuang , Chai Ruiyu , Zheng Pingping , Chen Yang , Pan Pan , Bi Chunli , Zhang Yulong , Yao Yan 
Published: July 2021

Abstract
Objective: to analyze the epidemic situation of COVID-19 in northeast China, Liaoning and Jilin. To study the prevalence of COVID-19 virus in areas other than Hubei province. To understand the spread of COVID-19 in Liaoning and Jilin provinces by means of communication network. More in-depth understanding of COVID-19 epidemic, and put forward effective prevention and control recommendations. Methods: We collected the demographic characteristics, exposure history and course of action of patients with laboratory-confirmed infection with COVID-19 published by Liaoning Provincial Health Commission and Jilin Provincial Health Commission as of February 15, 2020. We describe the demographic characteristics, case characteristics, spatial distribution characteristics and related interpersonal network of these patients. To analyze the transmission of COVID-19 in two provinces. Results: By February 15, 2020, the cumulative number of infected people in Liaoning province was 119.The largest number was 27(22.7%) in Shenyang and the smallest in Fushun, with no reported cases of infection. Among them, 55(46.2%) have a history of sojourning in Hubei province. The mainly clinical symptoms of the infected patients were fever, and 67(56.3%) of them developed fever at the time of diagnosis. Cough, sneezing and other respiratory symptoms are less. The cumulative number of infected people in Jilin province was 89, with the highest number in Changchun city at 39(43.8%) and the lowest in Baishan city, with no reported infections. 21(23.6%) people with a history of sojourning in Hubei province. Most of those infected in the two provinces were related to Hubei province, and most of those infected in the second generation or more were infected by close contact with relatives. Conclusion: The COVID-19 outbreaks in Liaoning and Jilin provinces are gradually stabilizing, but have not yet reached the time required to lower the prevention and control level. The fatality rate of the two provinces is relatively low. There is no evidence of super-spreader in either province.
A Comprehensive Bioinformatics Analysis of TIMP2 in Multiple Malignancies
Authors: Wang Dan-Dan , Xu Wen-Xiu , Chen Wen-Quan , Yang Su-Jin , Zhang Jian , Tang Jinhai 
Published: July 2021

Abstract
Background: Tissue inhibitor of metalloproteinase-2 (TIMP2), an endogenous inhibitor of matrix metalloproteinases, has been disclosed to participate in the development and carcinogenesis of multiple malignancies. However, the prognosis of TIMP2 in different cancers and its correlation with tumor microenvironment and immunity have not been clarified.Methods: In this study, we conducted a comprehensive bioinformatics analysis to evaluate the prognostic and therapeutic value of TIMP2 in cancer patients by utilizing a series of databases, including ONCOMINE, GEPIA, cBioPortal, GeneMANIA, Metascape, and Sangerbox online tool. The expression of TIMP2 in different cancers were analyzed by Oncomine, TCGA and GTEx databases and mutation status of TIMP2 in cancers was then verified using cBioportal database. The protein-protein interaction (PPI) network of the TIMP family was exhibited by GeneMANIA. The prognosis of TIMP2 in cancers was performed though GEPIA database and cox regression. Additionally, the correlations between TIMP2 expression and immunity (immune cells, gene markers of immune cells, TMB, MSI, and neoantigen) were explored using Sangerbox online tool.Results: The transcriptional level of TIMP2 in most cancerous tissues were significantly elevated. Survival analysis revealed that elevated expression of TIMP2 was associated with unfavorable survival outcome in multiple cancers. Enrichment analysis demonstrated the possible mechanisms of TIMPs and their associated genes mainly involved in pathways including extracellular matrix (ECM) regulators, degradation of ECM and ECM disassembly, and several other signaling pathways. Conclusions: Our findings systematically dissected that TIMP2 was a potential prognostic maker in various cancers and use the inhibitor of TIMP2 may be an effective strategy for cancer therapy to improve the poor cancer survival and prognostic accuracy, but concrete mechanisms need to be validated by subsequent experiments.
Coping Strategies Mediate the Association Between Stigma and Fertility Quality of Life in Infertile Women Undergoing in Vitro Fertilization-Embryo Transfer.
Authors: JING Xiaoyu , GU Wei , ZHANG Lu , MIAO Runna , XU Xiuli , WANG Min , RAMACHANDRAN Hadassah Joann , WANG Wenru 
Published: July 2021

Abstract
Background The mediating role of coping strategies and its relationship with psychological well-being and quality of life has been considered in the literature. However, there is little research to explore the mechanism of coping strategies on stigma and fertility quality of life (FertiQoL) in infertile women undergoing In Vitro Fertilization Embryo Transfer (IVF-ET). The aim of this study was to examine the mediating effect of coping strategies on the relationship between stigma and fertility quality of life (FertiQoL) in Chinese infertile women undergoing In Vitro Fertilization Embryo Transfer (IVF-ET).Methods: In this cross-sectional study, a total of 768 infertile women undergoing IVF-ET were recruited from Assisted Reproductive Center of Shaanxi Province, China. The personal information, infertility stigma scale, coping strategy scale and FertiQoL scale were measured using a set of questionnaires. The multiple mediator model was performed using AMOS 21.0.Results: The model showed a significant negative direct effect between stigma on FertiQoL (direct effect= -2.375, BC 95% CI= -2.764, -1.987). There were significantly negative indirect effects of stigma on FertiQoL through active-avoidance (indirect effect = -0.706; BC 95% CI = -0.950, -0.497), active-confronting (indirect effect = -0.267; BC 95% CI= -0.414, -0.136) and passive-avoidance (indirect effect= -0.244; BC 95% CI = -0.368, -0.142), respectively. The meaning-based coping played a positive intermediary role (indirect effect=0.105; BC 95% CI = 0.046, 0.190). The model explained 69.4% of the variance in FertiQoL.Conclusion: Active-avoidance coping strategy is the most important mediator factor between stigma and FertiQoL in infertile women undergoing IVF-ET treatment. Meaning-based coping strategy plays a positive mediating role between stigma and FertiQoL.
Cloning and Expressions of Chop in Loach (Misgurnus Anguillicaudatus) and Its Response to Hydrogen Peroxide (H2O2) Stress
Authors: Li Hui , Kang Minxin , Sun Shouxiang , Gao Jian , Jia Zhiying , Cao Xiaojuan 
Published: July 2021

Abstract
C/EBP [CCAAT/enhancer-binding protein]-homologous protein gene (chop) which plays an important role in endoplasmic reticulum stress-induced apoptosis, was investigated here by RACE and qPCR in an aquaculture animal for the first time. The full-length cDNA sequences of loach (Misgurnus anguillicaudatus) chop were 2533bp, encoding 266 amino acids. The expression levels of loach chop changed obviously during different early life stages, and the highest appeared at the 8-cell stage. Among different tissues, loach chop predominantly expressed in gill, spleen and gonad. Then, we performed a hydrogen peroxide (H2O2, a common-used disinfectant) stress trial to explore the role of loach chop, with three different concentrations (0 μM, 50 μM and 100 μM) of H2O2. Half of the loaches from the 100 μM group were dead, while all loaches from the other two treatment groups were alive. The activities of CAT, SOD and GPX in loach gill, liver and spleen decreased with extended stress time and increased H2O2 concentration. The expression levels of gill chop in loaches from the 100 μM group were significantly higher than those from the other two treatment groups between 12 and 24 hours of exposure. atf4 and bax, two proapoptotic genes, were significantly up-regulated in gills of loaches from the 100 μM group compared to the other two groups 18 hours and 24 hours after treatment, while bcl2, an antiapoptotic gene, presented an opposite trend. These results indicated a close relationship between H2O2 stress and fish apoptosis, and loach chop played an important role in H2O2 stress response.
Tracing historical changes, degradation, and original sources of airborne polycyclic aromatic hydrocarbons (PAHs) in Jilin Province, China, by Abies holophylla and Pinus tabuliformis needle leaves
Authors: Wang Zhao , Jin Xiangzi , Kaw Han Yeong , Fatima Zakia , Quinto Maurizio , Zhou John L. , Jin Dongri , He Miao , Li Donghao 
Published: July 2021

Abstract
Due to their wide distribution and availability, plant leaves can be considered interesting candidates as biomonitoring substrates for the evaluation of atmospheric pollution. In addition, some species can also retain historical information, for example, related to environmental pollution, due to their leaf class age. In this study, the content of polycyclic aromatic hydrocarbons (PAHs) in Abies holophylla and Pinus tabuliformis needle samples in function of their class age has been investigated to obtain information regarding the degradation constant for each PAH under investigation (α values ranging from 0.173 to 1.870) and to evaluate the possibility to correlate the presence of PAHs in needles with some important pollution environmental factors. Considering air pollutant variables registered in Jilin Province, significant correlations (at 95% confidence level) have been found between coal consumption per year and anthracene contents in needles, while fluorene, phenanthrene, and anthracene resulted correlated with coal consumption. Furthermore, it has been demonstrated that the total PAH concentration in needles, for both species, increased with their age (from 804 to 3604 ng g− 1 dry weight), showing a general tendency to accumulate these substances through years. PAH degradation rates increased instead with molecular complexity. This study could be considered a first trial to obtain historical environmental information by pine needles biomonitoring.
Drought Analysis During the Growth Stages of Grape in the Main Grape-Growing Regions in China
Authors: cheng xue , Sun Shuang , Liu Zhijuan , Yang Xiaoguang 
Published: July 2021

Abstract
In China, grape is one of the top five fruit crops for both bearing acreage and production. Recently, national grape production has been stalling because of an increase in drought events. In order to combat the adverse effects of drought on grape production, it is imperative to understand the historical drought trend and frequency during the growing season. In this study, we focused on agricultural drought during the four growth periods of grape: bud break-flowering, flowering-veraison, veraison-berry maturation, and berry maturation-leaf fall. Based on the weather data from 429 meteorological stations, we computed the Crop Water Deficit Index (CWDI) in the five main grape-growing regions of China: Northeast China, North China, Northwest China, Southwest China, and Southeast China. Then we evaluated the CWDI-based drought distribution and trend in the study regions, as well as the frequency of different degrees of drought. The results showed that exceptional drought was occurring frequently in Xinjiang Uyghur Autonomous Region, northern Gansu province, and northern Ningxia Hui Autonomous Region. Among the four study growth periods of grape, exceptional drought was the most expansive during bud break-flowering. What’s more, exceptional drought coverage during bud break-flowering in the study regions was increasing from 1981 to 2016. Analysis of butterfly structure showed that the occurrence of drought was continuous and persistent in northern China. Our study results could serve as guideposts to highlight Chinese grape production industry’s vulnerability to agricultural drought against the background of climate change.
Neuroimaging Findings of Posterior Reversible Encephalopathy Syndrome (PRES) Following Hematopoietic Stem Cell Transplantation in Pediatric Recipients
Authors: Atca Ali Onder , Erok Berrin , Aydogdu Selime 
Published: July 2021

Abstract
Background: Hematopoietic stem cell transplantation (HSCT) is the intravenous infusion of hematopoietic progenitor cells derived from bone marrow, umblical cord blood or peripheral blood to restore hematologic and immunologic functions of bone marrow. HSCT is the only curative treatment in many childhood disorders and is used worldwide. However, serious complications are still an important concern of management. Central nervous system (CNS) complications in pediatric HSCT recipients can be associated with high morbidity and mortality. Posterior reversible encephalopathy syndrome (PRES) is the most common of these neuroimaging abnormalities in patients having neurological symptoms following HSCT. The most common presentation is posterior encephalopathy in which the lesions are located at the posterior parts of cerebral hemispheres, namely parietooccipital lobes. However, it can also be found in non-posterior distribution and can be accompanied by various atypical imaging manifestattions like restricted diffusion. Methods: In this study, we aimed to describe the typical and also uncommon neuroimaging manifestations of PRES following HSCT in our pediatric patients.We evaluated the medical records of 300 pediatric HSCT recipients.Results: We detected 14 cases of PRES, of which there were 3 cases of atypical neuroimaging manifestations, regarding both the sites of involvement and also the magnetic resonance imaging (MRI) manifestations. Conclusion: Such different presentations should not dissuade the diagnosis of PRES in the appropriate clinical settings in order to manage these patients timely and accurately.
Spatiotemporal Assessment Of The Effect of Indoor Noise On Annoyance, Health And Comfort In Hospital Wards And Intensive Care Unit
Authors: Amoatey Patrick , Al-Harthy Issa , Al-Mushaifari Muntasar Ali , Al-Jabri Khalifa , Al-Mamun Abdullah 
Published: July 2021

Abstract
Hospital-noise levels can induce physiological responses, and affects sleep quality, which could contribute to cardiovascular-related health problems. Till date, high resolution hospital noise exposure assessment studies have not received much attention in Oman. This study aims at assessing sound pressure levels across hospital wards and intensive care unit (ICU) rooms to determine annoyance, and potential health effects based on perception and risk estimates. An indoor exposure assessment using high precision noise sensors was conducted in a female medical ward (FMW), isolated ward (SLW), emergency ward (EMW), and intensive care Unit (ICU) in a public hospital in Muscat city, Oman. Self–administered questionnaire was randomly distributed among respondents using both online and field survey approach to ascertain annoyance, health effects, and potential risks associated with exposure. The study found that 24–hr noise levels (LAeq) ranged from 55.2–61.7 dB(A) in the hospital wards and ICU rooms, which exceeded WHO’s hospital indoor rooms critical limit of 35 dB(A) by 58% – 76%. A total of 150 participants took part in the survey. Among the respondents, 53% reported moderate annoyance at the hospital wards while 56% felt sensitivity to the noise levels. Noise annoyance was reported by the majority of the patients across the various wards and emergency rooms as causing slight annoyance (50%) and intermittent sleep disturbances (49%). The majority (73%) of the medical staff have complained that the current noise levels affect overall work performance (p = 0.004), while 70% of them have further complained of it as a cause of workplace distraction (p = 0.011). Quantitative risk estimates showed that both the % of highly annoyed (HA) persons (16%), and highly sleep–disturbed (HSD) persons (9%) were very high in FMW, while ICU was found to have the lowest risk. However, the greater number of the respondents (87%) believed there are possibilities of mitigating (p <0.001) the current noise levels.
Study On the Driven Mechanism of Watershed Hydrological Drought Based on Geomorphological Spatial Distribution Pattern: A Case Study of Guizhou, China
Authors: he Zhonghua , Liang Hong , Yang Zhaohui 
Published: July 2021

Abstract
In recent years, hydrological drought has become more and more frequent, which has caused serious ecological and environmental problems. This paper is taking Guizhou province of China as an example to analyze the geomorphologic distribution and temporal-spatial evolution of hydrological droughts, and to study driving mechanisms of both the rainfall in the dry periods and geomorphologic factor on the hydrological droughts, based on the hydrometeorological data during the years 2000-2010, and the TM and DEM data. The results show that (1) the rainfall and its variation in the low-flow seasons have less impacts on the hydrologic drought and its variation; (2) the hydrologic drought severity in Guizhou was increasing year by year during the years 2000-2010, and showing the inter-annual variation with obvious stage characteristics, and the regional hydrologic drought was presented the more serious in the South than in the North, and the less serious in the East than in the West; and (3) in terms of the overall distribution of landform types, the mountain, hill and basin have less impacts on hydrological droughts; in terms of the distribution of single geomorphic type, hydrological droughts are significantly influenced by the high-medium mountain, deep-high hill and high basin, where the hydrological droughts are relatively lighter. While there are more serious areas in the low basin, shallow-low hill and low mountain.
Contractility of inverted internal limiting membrane flap after vitrectomy for macular hole
Authors: Hirata Akira , Mine Keiko , Hayashi Ken 
Published: July 2021

Abstract
We investigated the postoperative visual outcomes and morphological changes of the internal limiting membrane (ILM) flap, in patients who underwent the inverted ILM flap technique for macular hole (MH). Between August 2018 and February 2020, 22 eyes of 22 patients with idiopathic or myopic MH who underwent vitrectomy with ILM flap were included in this study and followed-up for more than six months. Postoperative MH status, comparison of best-corrected visual acuity (BCVA) before and six months after surgery, changes in the ILM flap area at one and six months postoperatively, and the factors related to changes in ILM flap size, were analyzed. MH closure was achieved in all of the patients. The BCVA at six months postoperatively (0.18 ± 0.15) was significantly better than the preoperative BCVA of 0.63 ± 0.37 (P = 0.000005, paired t-test). The area of the ILM flap decreased significantly from 3.25 ± 1.27 mm2 at one month to 3.13 ± 1.23 mm2 at six months (P = 0.024, Wilcoxon signed-rank test). Two eyes showed an ILM flap contraction of more than 20%, and one eye required re-operation due to an increase in metamorphopsia and decreased visual acuity. Among age, sex, ILM flap area at one month, preoperative BCVA, and axial length, ILM flap contraction was correlated with patient age and ILM flap area. Although vitrectomy with the inverted ILM flap technique confers a good visual outcome, the ILM flap may contract in younger patients.
Investigation and Analysis of Sanitation-Related Knowledge and Hygiene Routines Among China’s WASH Plus Program Students
Authors: Cha Yu-E , Fu Yuan-Zheng , Chen Guo-Liang , Yao Wei 
Published: July 2021

Abstract
Objective: This study was performed to determine the knowledge level of students in China’s WASH Plus Program about sanitation and hygiene practices to provide a scientific basis for well-targeted health education.Methods: The researchers randomly selected one fourth-grade class from each of the 12 schools in each of the five WASH Plus Program provinces (municipalities or autonomous regions). The students in the selected fourth-grade classes were then asked to complete a self-designed questionnaire. Chi-square testing and Bonferroni correction were used for paired and multiple comparisons of the enumeration data, respectively. Results: The 2330 respondents (mean age, 9.9 ± 0.3 years) included 1151 male students (49.40%), 1489 students of minority (non-Han) ethnicity (63.91%), and 433 boarding students (18.58%). Overall, 81.09% of the students were found to have gained sanitation-related knowledge, and 79.64% had formed hygiene routines. Specifically, only 41.76% of students knew that “diarrhea can be transmitted through contaminated water,” and 68.88% of students were aware that “diarrhea can be prevented by not drinking untreated water.” In addition, only 67.94%, 62.83%, and 62.62% of students “wash hands with running water and soap/hand sanitizer at school,” “never drink untreated water at school,” and “never drink untreated water at home,” respectively. Regionally, 88.54%, 87.13%, 79.13%, 77.23%, and 72.81% of students in Chongqing, Yunnan, Guangxi, Guizhou, and Xinjiang, respectively, had strong knowledge of sanitation, and 92.11%, 80.70%, 74.04%, 79.43%, and 69.86% of them practiced hygiene. In terms of gender, 80.53% of male students and 81.64% of female students had acquired sanitation-related knowledge, whereas 77.45% of male students and of 81.78% female students had adopted hygiene practices. The total awareness rates of sanitation-related knowledge for Han students and minority students were 83.10% and 79.96%, respectively. Approximately 85.53% of Han students and 76.32% of minority students had formed good hygiene routines. Some 81.32% of boarding students and 81.04% of non-boarding students had strong knowledge of sanitation, and 78.65% and 79.87%, respectively, had formed good hygiene habits. Conclusions: Some of the students surveyed had insufficient hygiene knowledge, and a small number had poor hygiene habits. To provide students with well-targeted health education, improve their hygiene awareness, and change their bad habits, full consideration should be given to factors such as region, gender, ethnicity, boarding status, and the influence of the process via which students acquire hygiene knowledge and form effective hygiene routines.