bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between hepatitis B virus infection and nonliver malignancies in persons living with HIV: results from the EuroSIDA study
Authors: Mocroft Amanda , Miro Jose M. , Wandeler Gilles , Llibre Josep M. , Boyd Anders , van Bremen Kathrin , Beniowski Marek , Mikhalik Julia , Cavassini Matthias , Maltez Fernando , Duvivier Claudine , Uberti Foppa Caterina , Knysz Brygida , Bakowska Elzbieta , Kuzovatova Elena , Domingo Pere , Zagalo Alexandra , Viard Jean‐Paul , Degen Olaf , Milinkovic Ana , Benfield Thomas , Peters Lars ,   the EuroSIDA study group
Published: December 2021

AbstractObjectivesThe aim of this study was to assess the impact of hepatitis B virus (HBV) infection on non‐liver malignancies in people living with HIV (PLWH).MethodsAll persons aged ≥ 18 years with known hepatitis B virus (HBV) surface antigen (HBsAg) status after the latest of 1 January 2001 and enrolment in the EuroSIDA cohort (baseline) were included in the study; persons were categorized as HBV positive or negative using the latest HBsAg test and followed to their first diagnosis of nonliver malignancy or their last visit.ResultsOf 17 485 PLWH included in the study, 1269 (7.2%) were HBV positive at baseline. During 151 766 person‐years of follow‐up (PYFU), there were 1298 nonliver malignancies, 1199 in those currently HBV negative [incidence rate (IR) 8.42/1000 PYFU; 95% confidence interval (CI) 7.94–8.90/1000 PYFU] and 99 in those HBV positive (IR 10.54/1000 PYFU; 95% CI 8.47–12.62/1000 PYFU). After adjustment for baseline confounders, there was a significantly increased incidence of nonliver malignancies in HBV‐positive versus HBV‐negative individuals [adjusted incidence rate ratio (aIRR) 1.23; 95% CI 1.00–1.51]. Compared to HBV‐negative individuals, HBsAg‐positive/HBV‐DNA‐positive individuals had significantly increased incidences of nonliver malignancies (aIRR 1.37; 95% CI 1.00–1.89) and NHL (aIRR 2.57; 95% CI 1.16–5.68). There was no significant association between HBV and lung or anal cancer.ConclusionsWe found increased rates of nonliver malignancies in HBsAg‐positive participants, the increases being most pronounced in those who were HBV DNA positive and for NHL. If confirmed, these results may have implications for increased cancer screening in HIV‐positive subjects with chronic HBV infection.
Observational learning: Influence of regulatory focus, knowledge, and summarized observable recommendations on consumer decision outcomes in an online environment
Authors: Patil Ashutosh , Malhotra Naresh K. , Maity Moutusy 
Published: December 2021

AbstractWhen consumers have access to a large number of reviews for a product on multiple e‐tailer websites, they may rely mainly on aggregated summaries of online reviews (SORs) (e.g., percentage of reviewers recommending a product) instead of on textual content of individual reviews. The SOR type may be “High” (when a majority of reviewers recommend a product on multiple merchant websites), “Low” (when only a minority of reviewers recommend a product on multiple merchant websites), or “Mixed” (when a majority and a minority of reviewers recommend the same product across different websites). Consumers’ prior product knowledge and regulatory focus moderate the impact of SOR type on consumer decision outcomes. Across three studies (representing low, moderate, and high levels of consumer knowledge), we find that negativity bias holds across both promotion and prevention foci in the Low‐SOR condition. In the High‐SOR condition, the level of prior knowledge moderates the relationship between SOR and purchase intention. Mixed‐SOR has no effect. We also propose and find support for a framework for SORs by extending Banduraʼs observational learning theory. Finally, we discuss the theoretical and managerial implications.
Generation of a single‐tube quality control material for hemoglobin and DNA analyses of hemoglobinopathies
Authors: Pansuwan Anupong , Changtrakul Duangrudee , Chaibunruang Attawut , Yamsri Supawadee , Sanchaisuriya Kanokwan , Fucharoen Goonnapa , Fucharoen Supan 
Published: December 2021

AbstractIntroductionHemoglobinopathies are major public health problems worldwide. Accurate laboratory diagnosis of the carrier is essential, which includes initial screening, Hb analysis, and DNA analysis. For the first time, we have developed a single‐tube quality control (QC) sample for these laboratory tests.MethodsThe QC sample was made from a lyophilized mixture of the stabilized hemolysate with carbon monoxide saturation and the white blood cells of known thalassemia mutations. Homogeneity and stability were examined by Hb and DNA analyses on day 0 and every month for 12 months, at room temperature, 4°C, and −20°C. A preliminary proficiency testing (PT) program for hemoglobinopathies using this single QC material was developed.ResultsHemoglobin (Hb) and DNA analyses of a single‐tube QC sample demonstrated satisfactory results of Hb analysis for at least five months and DNA analysis for at least one year of storage at −20°C. The results obtained from a preliminary PT program on five expert laboratories confirmed that a single tube QC sample prepared could be used as a PT item with various Hb and DNA analyses methods.ConclusionA single lyophilized control sample has been generated for use in hemoglobinopathies’ internal and external quality control program. Unlike other available control materials, which are used for individual testing, a single‐tube QC sample generated can be used to control the pre‐analytical and analytical processes of both Hb and DNA analyses and is suitable for use in the PT program of hemoglobinopathies.
A randomized controlled trial of technology‐enhanced behavioral parent training: sustained parent skill use and child outcomes at follow‐up
Authors: Parent Justin , Anton Margaret T. , Loiselle Raelyn , Highlander April , Breslend Nicole , Forehand Rex , Hare Megan , Youngstrom Jennifer K. , Jones Deborah J. 
Published: December 2021

BackgroundEarly‐onset (3–8 years old) disruptive behavior disorders (DBDs) have been linked to a range of psychosocial sequelae in adolescence and beyond, including delinquency, depression, and substance use. Given that low‐income families are overrepresented in statistics on early‐onset DBDs, prevention and early‐intervention targeting this population is a public health imperative. The efficacy of Behavioral Parent Training (BPT) programs such as Helping the Noncompliant Child (HNC) has been called robust; however, given the additional societal and structural barriers faced by low‐income families, family engagement and retention barriers can cause effects to wane with time. This study extends preliminary work by examining the potential for a Technology‐Enhanced HNC (TE‐HNC) program to improve and sustain parent skill proficiency and child outcomes among low‐income families.MethodsA randomized controlled trial with two parallel arms was the design for this study. A total of 101 children (3–8‐years‐old) with clinically significant problem behaviors from low‐income households were randomized to HNC (n = 54) or TE‐HNC (n = 47). Participants were assessed at pre‐treatment, post‐treatment, 3‐month, and 6‐month follow‐ups. Primary outcomes were parent‐reported and observed child behavior problems. Secondary outcomes included observed parenting skills use (ClinicalTrials.gov Identifier: NCT02191956).ResultsPrimary analyses used latent curve modeling to examine treatment differences in the trajectory of change during treatment, maintenance of treatment gains, and levels of outcomes at the 6‐month follow‐up. Both programs yielded improvements in parenting skills and child problems at post‐treatment. However, TE‐HNC families evidenced greater maintenance of parent‐reported and observed child behavior and observed positive parenting skills at the 6‐month follow‐up.ConclusionsOur findings contribute to an ongoing line of work suggesting that technology‐enhanced treatment models hold promise for increasing markers of engagement in BPT and sustaining long‐term outcomes among low‐income families.
Executive function and intellectual disability: innovations, methods and treatment
Authors: Fidler D. J. , Lanfranchi S. 
Published: December 2021

AbstractThis editorial presents an introduction to and an overview of the current JIDR special issue on “Executive Function in Intellectual Disability.” The articles included in this special issue provide a contemporary, in depth exploration of questions regarding the nature of EF in individuals with ID. Topics include the emergence of EF during early childhood in ID‐related conditions, the influence of EF on other domains of development, and the relationship between EF and adaptation throughout the lifespan. This editorial synthesizes the findings presented in this special issue and identifies methodological challenges that researchers will continue to face in future investigations of this important area.
Desired fertility and educational aspirations: Adolescent goals in rapidly changing social contexts
Authors: Alcaraz Melissa , Hayford Sarah R. , Glick Jennifer E. 
Published: December 2021

AbstractObjectiveThis article analyzes the relationship between educational aspirations and fertility aspirations early in the life course in three different settings.BackgroundThe negative relationship between women's educational attainment and childbearing is one of the most consistent associations in social science. Family scholars have a more limited understanding of the relationship between educational aspirations and fertility aspirations before childbearing or union formation.MethodThe authors use data collected in Jalisco, Mexico; Gaza, Mozambique; and Chitwan Valley, Nepal as part of the Family Migration and Early Life Outcomes project. They estimate nested Poisson regressions to model the relationship between adolescent educational aspirations and desired family size, controlling for individual‐ and household‐level sociodemographic variables as well as adolescent beliefs and values.ResultsOn average, adolescents who desire more education want fewer children in unadjusted models. In Mozambique and Nepal, this association is attenuated in models accounting for household characteristics. In Mexico, the association persists after incorporating these factors, but the inclusion of individual aspirations attenuates the relationship between educational aspirations and desired family size. In Mozambique, the association of educational aspirations with desired family size is moderated by gender.ConclusionAs young people enter adolescence, their desires for education and childbearing are inversely related, but the mechanisms driving this association vary across contexts. This variation may be related to linkages between education, social status, and family values.
Evaluation of Microshear Bond Strength of Four Different CAD‐CAM Polymer‐Infiltrated Ceramic Materials after Thermocycling
Authors: Beyabanaki Elaheh , Eftekhar Ashtiani Reza , Feyzi Marjan , Zandinejad Amirali 
Published: December 2021

AbstractPurposeTo evaluate the bond strength of three monolithic hybrid ceramics/resin nanoceramics and a zirconia‐reinforced lithium silicate to resin cement after thermocycling.Materials and MethodsUsing four materials, including Vita Enamic (VITA Zahnfabrik), Lava Ultimate (3M ESPE), Crystal Ultra (Digital Dental), and Vita Suprinity (VITA Zahnfabrik), 64 specimens were prepared with dimensions of 4 mm × 3 mm × 1.5 mm. Vita Suprinity samples were sintered at 840°C for 8 min. After polishing and cleaning all the samples in each group (n = 16), they were subjected to their recommended surface treatment: 10% hydrofluoric acid for Vita Enamic (60s) and Vita Suprinity (20s); air abrasion of Lava Ultimate and Crystal Ultra with 50 u Al2O3 particles. Then, tygon tubes were filled with dual cure resin cement (Panavia F2.0), cured and then subjected to thermal cycling (2000 cycles; 5‐55°C). The microshear bond strength was measured using microtensile testing machine. The data were analyzed using Welch and Games‐Howell tests (α = 0.05). The mode of failure was also evaluated using a stereomicroscope.ResultsThe highest and the lowest mean microshear bond strength belonged to the Crystal Ultra (7.71 ± 1.54 MPa) and Vita Suprinity (4.73 ± 1.87 MPa) groups, respectively. The differences between groups were significant and Crystal Ultra had higher bond strength in comparison to all three materials (p < 0.05).ConclusionHybrid ceramics showed higher bond strength to resin cements in comparison to resin nanoceramics and zirconia‐reinforced lithium silicate materials.
Accuracy of controlled attenuation parameter for assessing liver steatosis in individuals with morbid obesity before bariatric surgery
Authors: Tavaglione Federica , De Vincentis Antonio , Bruni Vincenzo , Gallo Ida Francesca , Carotti Simone , Tuccinardi Dario , Spagnolo Giuseppe , Ciociola Ester , Mancina Rosellina Margherita , Jamialahmadi Oveis , D’Alessio Rossella , Bottazzi Bruna , Manfrini Silvia , Picardi Antonio , Perrone Giuseppe , Pozzilli Paolo , Caricato Marco , Vespasiani‐Gentilucci Umberto , Romeo Stefano 
Published: December 2021

AbstractBackground & AimsThe ultrasound‐based controlled attenuation parameter (CAP) is a non‐invasive tool widely validated for assessing liver steatosis across different etiologies. However, few studies, with liver biopsy available, have investigated its performance in individuals with morbid obesity. Herein, we aimed to evaluate the diagnostic accuracy of CAP in participants with morbid obesity from the MAFALDA study before bariatric surgery.MethodsA total of 120 individuals with valid examinations within three months from bariatric surgery were included. Clinical, laboratory, FibroScan® (XL probe), and liver biopsy data were collected using standardized procedures. The overall accuracy of CAP for detecting liver steatosis was estimated by the area under the receiver‐operating characteristics curve (AUROC). Optimal cut‐offs were chosen at points with the highest Youden index.ResultsThe AUROCs of CAP for detecting S ≥ S1, S ≥ S2, and S = S3 were 0.91 (95% CI 0.86–0.97), 0.83 (95% CI 0.76–0.90), and 0.86 (95% CI 0.79–0.94), respectively. The best CAP cut‐offs for S ≥ S1, S ≥ S2, and S = S3 were 300 dB/m (95% CI 275–316), 328 dB/m (95% CI 296–345), and 344 dB/m (95% CI 343–352), respectively. CAP values were independently influenced by steatosis grade (estimate 20.60, 95% CI 12.70–28.40, P = 1.05 × 10−6). The AUROC of FibroScan‐AST (FAST) score for detecting progressive non‐alcoholic steatohepatitis was 0.76 (95% CI 0.66–0.86).ConclusionsIn individuals with morbid obesity, CAP measured by XL probe is an accurate non‐invasive tool for grading liver steatosis. Measurement of liver fat content by CAP may help identify those eligible for bariatric procedures and estimate the effect of bariatric surgery on hepatic steatosis.Lay SummaryThe ultrasound‐based controlled attenuation parameter (CAP) by using the XL probe has an excellent performance for grading liver steatosis among individuals with morbid obesity.CAP may represent an accurate tool for the non‐invasive assessment of liver steatosis among individuals with morbid obesity before and after bariatric surgery.
Junior doctors' experiences with interprofessional collaboration: Wandering the landscape
Authors: van Duin Titia S. , de Carvalho Filho Marco A. , Pype Peter F. , Borgmann Susanne , Olovsson Matts H. , Jaarsma A. Debbie C. , Versluis Marco A. C. 
Published: December 2021

AbstractContextThe transition from medical student to junior doctor is challenging. Junior doctors need to become part of the physician community of practice (CoP), while dealing with new responsibilities, tasks and expectations. At the same time, they need to learn how to navigate the frontiers and intersections with the other communities of practice that form the Landscape of Practice (LoP). This study aims to understand how junior doctors experience interprofessional collaboration (IPC) and what elements shape these experiences considering their transition to clinical practice.MethodsIn this multicentre qualitative study, 13 junior doctors individually drew two rich pictures of IPC experiences, one positive and one negative. A rich picture is a visual representation, a drawing of a particular situation intended to capture the complex and non‐verbal elements of an experience. We used semi‐structured interviews to deepen the understanding of junior doctors' depicted IPC experiences. We analysed both visual materials and interview transcripts iteratively, for which we adopted an inductive constructivist thematic analysis.ResultsWhile transitioning into a doctor, junior doctors become foremost members of the physician CoP and shape their professional identity based on perceived values in their physician community. Interprofessional learning occurs implicitly, without input from the interprofessional team. As a result, junior doctors struggle to bridge the gap between themselves and the interprofessional team, preventing IPC learning from developing into an integrative process. This professional isolation leaves junior doctors wandering the landscape of practice without understanding roles, attitudes and expectations of others.ConclusionsLearning IPC needs to become a collective endeavour and an explicit learning goal, based on multisource feedback to take advantage of the expertise already present in the LoP. Furthermore, junior doctors need a safe environment to embrace and reflect on the emotions aroused by interprofessional interactions, under the guidance of experienced facilitators.
Primary cutaneous mucormycosis in a premature neonate treated conservatively with amphotericin B
Authors: Vittitow Stephany L. , Rusu Corina A. , Abubakar Maryam O. , Burnsed Jennifer , Gru Alejandro A. , Zlotoff Barrett J. 
Published: December 2021

AbstractCutaneous mucormycosis is a rare, often fatal fungal infection that most commonly affects patients with underlying immunosuppression but also can occur in premature neonates. We report the case of an extremely premature boy (<25 weeks) who developed primary cutaneous mucormycosis shortly after birth. Although surgical debridement has been a mainstay of treatment in combination with antifungal therapy, our patient was successfully treated with amphotericin B alone—the management only reported in three other cases to date. We present this case to highlight that prompt initiation of treatment with amphotericin B alone may be an appropriate alternative to surgical intervention, particularly in patients with non‐angioinvasive disease who are poor surgical candidates.
A case of prolidase deficiency in a male patient
Authors: Haller Courtney N. , George‐Abraham Jaya K. , Peterson Rosemary G. , Diaz Lucia Z. 
Published: December 2021

AbstractProlidase deficiency is an extremely rare, autosomal recessive disorder resulting in defective collagen formation. We report a case of prolidase deficiency in a male child, highlighting the dermatologic features. Early diagnosis is important as these patients encounter significant multisystem comorbidities requiring multispecialty care.
Effect of powdery mildew on antioxidant enzymes of wheat grain
Authors: Gao Hongyun , Niu Jishan , Zhao Wanyong , Zhang Dale , Li Suoping , Liu Yumiao 
Published: December 2021

AbstractPowdery mildew caused by Blumeria graminis f. sp. tritici (Bgt) is a severe leaf disease in wheat (Triticum aestivum). To elucidate the effect of powdery mildew on cell redox homeostasis in grains, three wheat cultivars with different resistance, Xi'nong 979 (susceptible), Zhengmai 379 (moderately susceptible), and Zhengmai 103 (resistant), were inoculated with Bgt in the field, and the changes in gene transcription and activity of the antioxidant enzymes in developing grains were analysed. The results showed that the gene expression patterns and enzyme activity changes of guaiacol peroxidase (POD), catalase (CAT), dehydroascorbate reductase (DHAR), glutathione reductase (GR), and 1‐Cys peroxiredoxin (1‐Cys Prx) were similar under powdery mildew conditions. They increased significantly at 10–20 days after anthesis (DAA) in susceptible cultivars and at 20–30 DAA in the resistant cultivar. However, they showed a significant decrease in susceptible cultivars at 20–30 DAA. The gene expression and enzyme activity of ascorbate peroxidase (APX) and monodehydroascorbate reductase (MDHAR) increased continuously during grain development, especially in susceptible cultivars. The results demonstrated that the antioxidant systems were induced under mild powdery mildew conditions, which was conducive to the synchronous regulation of reactive oxygen species (ROS). However, under severe powdery mildew conditions, the antioxidant systems were inhibited and the regulation of ROS was restricted, resulting in the breakdown of cell redox homeostasis. It is speculated that powdery mildew infection can inhibit the activity of some metabolic proteins (transcription factors or enzymes), change the carbon and nitrogen metabolism of grain cells, and further change the quality of wheat grains.
LncRNA‐mediated ceRNA networks provide novel potential biomarkers for peanut drought tolerance
Authors: Ren Jingyao , Jiang Chunji , Zhang He , Shi Xiaolong , Ai Xin , Li Rengyuan , Dong Jiale , Wang Jing , Zhao Xinhua , Yu Haiqiu 
Published: December 2021

AbstractDrought stress has been the major constraint on peanut yield and quality, and an understanding of the function of long non‐coding (lncRNAs) in the peanut drought stress response is still in its infancy. In this study, two peanut varieties with contrasting drought tolerance were used to explore the functions of lncRNAs in the peanut drought response, and the results showed that the drought‐tolerant variety presented greater antioxidant enzyme activity, osmotic adjustment ability, and photosynthesis under drought conditions. There were 4329 lncRNAs identified in the two varieties, of which 535 and 663 lncRNAs were differentially expressed in NH5 and FH18, respectively. The cis targets of the differentially expressed lncRNAs were putatively involved in secondary metabolite biosynthesis and other basic metabolic processes. A total of 673 competing endogenous RNA (ceRNA) pairs were selected specifically in NH5, and the associated ceRNA network revealed six lncRNAs, MSTRG.70535.2, MSTRG.86570.2, MSTRG.86570.1, MSTRG.100618.1, MSTRG.81214.2, and MSTRG.30931.1were considered as hub nodes. They were speculated to contribute to enhancing peanut drought tolerance, such as regulating transcription and plant growth processes, thereby improving the drought stress response. In this study, lncRNAs and mRNAs interaction networks were constructed to aid a comprehensive understanding of the peanut drought stress response and form a basis for future research.
Attributes‐based conjoint analysis of landowner preferences for standing timber insurance
Authors: Deng Yiling , Munn Ian A. , Yao Haibo 
Published: December 2021

AbstractThere is a growing interest in developing a standing timber insurance market because of natural catastrophes and climate change, yet private forests are rarely insured worldwide. Landowner preferences for standing timber insurance's multiple attributes are essential to study the insurance demand. We use conjoint analysis to elicit the preferences and to measure the importance and value of attribute levels. We find that insurance premium is the most relevant and important attribute, followed by insurance coverage and deductible. The willingness‐to‐pay for the broadest insurance coverage and the lowest deductible can be as high as $2.54 per $1000 and $1.89 per $1000, respectively. We identify four market segments corresponding to landowner preferences: (a) premium desirers who are price sensitive; (b) provider pickers who prefer government providing insurance; (c) coverage seekers who concern perils; and (d) balanced buyers who consider price, deductible and coverage equally. This study provides useful information on the demand for standing timber insurance which allows the market to design policies to better meet landowners' needs.