bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of CASR A990G polymorphism in response to cinacalcet treatment in hemodialysis patients with secondary hyperparathyroidism
Authors: Ngamkam Jaruwan , Vadcharavivad Somratai , Areepium Nutthada , Auamnoy Titinun , Takkavatakarn Kullaya , Katavetin Pisut , Tiranathanagul Khajohn , Praditpornsilpa Kearkiat , Eiam-Ong Somchai , Susantitaphong Paweena 
Published: September 2021

AbstractThe objective of this study was to determine the impact of calcium sensing receptor (CASR) A990G genetic polymorphism on parathyroid hormone (PTH) lowering response to cinacalcet treatment when controlling for significant influencing clinical factors. This retrospective study was conducted on 135 Thai hemodialysis (HD) patients with secondary hyperparathyroidism (SHPT). CASR A990G genotypes were determined. The patients were identified as either G carriers (heterozygous or homozygous CASR 990G allele carriers) or noncarriers (homozygous CASR 990A carriers). Tested covariates were baseline PTH level (bPTH), baseline serum phosphate (bPhos), baseline serum calcium (bCa), baseline calcitriol equivalent dose (bCtriol), baseline ergocalciferol dose (bErgo), and age. The ANCOVA showed that intact PTH levels after 12 weeks of cinacalcet treatment (PTHw12) was significantly lower among G carriers compared with noncarriers after controlling for bPTH, bPhos, bCtriol, and bErgo (F(1, 127) = 15.472, p < 0.001), with the adjusted mean difference of 253.7 pg/mL. The logistic regression analysis revealed that the odds of a G carrier achieving 30% PTH reduction after 12-week cinacalcet treatment were 3.968 times greater than the odds for a noncarrier after adjusting for bPhos, bCtriol, and age. In conclusion, the CASR A990G polymorphism significantly influences cinacalcet response in HD patients with SHPT.
Making assembly line in supply chain robust and secure using UHF RFID
Authors: Sharif Abubakar , Kumar Rajesh , Ouyang Jun , Abbas Hasan T. , Alomainy Akram , Arshad Kamran , Assaleh Khaled , Althuwayb Ayman , Imran Muhammad Ali , Abbasi Qammer H. 
Published: September 2021

AbstractThis paper presents a block-chain enabled inkjet-printed ultrahigh frequency radiofrequency identification (UHF RFID) system for the supply chain management, traceability and authentication of hard to tag bottled consumer products containing fluids such as water, oil, juice, and wine. In this context, we propose a novel low-cost, compact inkjet-printed UHF RFID tag antenna design for liquid bottles, with 2.5 m read range improvement over existing designs along with robust performance on different liquid bottle products. The tag antenna is based on a nested slot-based configuration that achieves good impedance matching around high permittivity surfaces. The tag was designed and optimized using the characteristic mode analysis. Moreover, the proposed RFID tag was commercially tested for tagging and billing of liquid bottle products in a conveyer belt and smart refrigerator for automatic billing applications. With the help of block-chain based product tracking and a mobile application, we demonstrate a real-time, secure and smart supply chain process in which items can be monitored using the proposed RFID technology. We believe the standalone system presented in this paper can be deployed to create smart contracts that benefit both the suppliers and consumers through the development of trust. Furthermore, the proposed system will paves the way towards authentic and contact-less delivery of food, drinks and medicine in recent Corona virus pandemic.
Development and validation of a novel risk assessment model to estimate the probability of pulmonary embolism in postoperative patients
Authors: Wang Mao-feng , Li Fei-xiang , Feng Lan-fang , Zhu Chao-nan , Fang Shuang-yan , Su Cai-min , Yang Qiong-fang , Ji Qiao-ying , Li Wei-min 
Published: September 2021

AbstractPulmonary embolism (PE) is a leading cause of mortality in postoperative patients. Numerous PE prevention clinical practice guidelines are available but not consistently implemented. This study aimed to develop and validate a novel risk assessment model to assess the risk of PE in postoperative patients. Patients who underwent Grade IV surgery between September 2012 and January 2020 (n = 26,536) at the Affiliated Dongyang Hospital of Wenzhou Medical University were enrolled in our study. PE was confirmed by an identified filling defect in the pulmonary artery system in CT pulmonary angiography. The PE incidence was evaluated before discharge. All preoperative data containing clinical and laboratory variables were extracted for each participant. A novel risk assessment model (RAM) for PE was developed with multivariate regression analysis. The discrimination ability of the RAM was evaluated by the area under the receiver operating characteristic curve, and model calibration was assessed by the Hosmer–Lemeshow statistic. We included 53 clinical and laboratory variables in this study. Among them, 296 postoperative patients developed PE before discharge, and the incidence rate was 1.04%. The distribution of variables between the training group and the validation group was balanced. After using multivariate stepwise regression, only variable age (OR 1.070 [1.054–1.087], P < 0.001), drinking (OR 0.477 [0.304–0.749], P = 0.001), malignant tumor (OR 2.552 [1.745–3.731], P < 0.001), anticoagulant (OR 3.719 [2.281–6.062], P < 0.001), lymphocyte percentage (OR 2.773 [2.342–3.285], P < 0.001), neutrophil percentage (OR 10.703 [8.337–13.739], P < 0.001), red blood cell (OR 1.872 [1.384–2.532], P < 0.001), total bilirubin (OR 1.038 [1.012–1.064], P < 0.001), direct bilirubin (OR 0.850 [0.779–0.928], P < 0.001), prothrombin time (OR 0.768 [0.636–0.926], P < 0.001) and fibrinogen (OR 0.772 [0.651–0.915], P < 0.001) were selected and significantly associated with PE. The final model included four variables: neutrophil percentage, age, malignant tumor and lymphocyte percentage. The AUC of the model was 0.949 (95% CI 0.932–0.966). The risk prediction model still showed good calibration, with reasonable agreement between the observed and predicted PE outcomes in the validation set (AUC 0.958). The information on sensitivity, specificity and predictive values according to cutoff points of the score in the training set suggested a threshold of 0.012 as the optimal cutoff value to define high-risk individuals. We developed a new approach to select hazard factors for PE in postoperative patients. This tool provided a consistent, accurate, and effective method for risk assessment. This finding may help decision-makers weigh the risk of PE and appropriately select PE prevention strategies.
Carotid smooth muscle contractility changes after severe burn
Authors: DeSpain Kevin , Rosenfeld Charles R. , Huebinger Ryan , Wang Xiaofu , Jay Jayson W. , Radhakrishnan Ravi S. , Wolf Steven E. , Song Juquan 
Published: September 2021

AbstractSevere burns result in cardiovascular dysfunction, but responses in the peripheral vasculature are unclear. We hypothesize that severe burns disturb arterial contractility through acute changes in adrenergic and cholinergic receptor function. To address this, we investigated the changes in carotid artery contractility and relaxation following a severe burn. Thirty-four adult Sprague–Dawley male rats received a 40% total body surface area (TBSA) scald burn and fluid resuscitation using the Parkland formula. Control animals received sham burn procedure. Animals were serially euthanized between 6 h and 14 days after burn and endothelium-intact common carotid arteries were used for ex vivo force/relaxation measurements. At 6 h after burn, carotid arteries from burned animals demonstrated a > 50% decrease in cumulative dose-responses to norepinephrine (p < 0.05) and to 10−7 M angiotensin II (p < 0.05). Notably, pre-constricted carotid arteries also demonstrated reduced relaxation responses to acetylcholine (p < 0.05) 6 h after burn, but not to sodium nitroprusside. Histologic examination of cross-sectional planes revealed significant increases in carotid artery wall thickness in burned rats at 6 h versus 3 days, with increased collagen expression in tunica media at 3 days (p < 0.05). Carotid artery dysfunction occurs within 6 h after severe burn, demonstrating decreased sensitivity to adrenergic- and angiotensin II-induced vasoconstriction and acetylcholine-induced relaxation.
Real-world data analyses unveiled the immune-related adverse effects of immune checkpoint inhibitors across cancer types
Authors: Wang Feicheng , Yang Shihao , Palmer Nathan , Fox Kathe , Kohane Isaac S. , Liao Katherine P. , Yu Kun-Hsing , Kou S. C. 
Published: September 2021

AbstractImmune checkpoint inhibitors have demonstrated significant survival benefits in treating many types of cancers. However, their immune-related adverse events (irAEs) have not been systematically evaluated across cancer types in large-scale real-world populations. To address this gap, we conducted real-world data analyses using nationwide insurance claims data with 85.97 million enrollees across 8 years. We identified a significantly increased risk of developing irAEs among patients receiving immunotherapy agents in all seven cancer types commonly treated with immune checkpoint inhibitors. By six months after treatment initialization, those receiving immunotherapy were 1.50–4.00 times (95% CI, lower bound from 1.15 to 2.16, upper bound from 1.69 to 20.36) more likely to develop irAEs in the first 6 months of treatment, compared to matched chemotherapy or targeted therapy groups, with a total of 92,858 patients. The risk of developing irAEs among patients using nivolumab is higher compared to those using pembrolizumab. These results confirmed the need for clinicians to assess irAEs among cancer patients undergoing immunotherapy as part of management. Our methods are extensible to characterizing the effectiveness and adverse effects of novel treatments in large populations in an efficient and economical fashion.
Negative Pressure Wound Therapy: Mechanism of Action and Clinical Applications
Authors: Normandin Shanel , Safran Tyler , Winocour Sebastian , Chu Carrie K. , Vorstenbosch Joshua , Murphy Amanda M. , Davison Peter G. 
Published: September 2021

AbstractNegative pressure wound therapy (NPWT) promotes healing by evenly applying negative pressure on the surface of the wound. The system consists of a sponge, a semiocclusive barrier, and a fluid collection system. Its effectiveness is explained by four main mechanisms of action, including macrodeformation of the tissues, drainage of extracellular inflammatory fluids, stabilization of the environment of the wound, and microdeformation. Rarely will complications linked to NPWT occur, but special care must be taken to prevent events such as toxic shock syndrome, fistulization, bleeding, and pain. New NPWT modalities have been recently developed to make NPWT suitable for a wider variety of wounds. These include NPWT with instillation therapy (NPWTi-d), different cleansing options, and application of NPWT on primarily closed incisions. Finally, vacuum-assisted wound closure therapy has been demonstrated to be efficient for various clinical settings, such as the management of diabetic foot ulcers, pressure ulcerations, chronic wounds, and skin grafts.
The Use of Bulk Fill Resin-Based Composite in the Sealing of Cavity with Margins in Radicular Cementum
Authors: Francesco Puleio , Gabriele Cervino , Fiorillo Luca , Giuseppe Miragliotta , Antonella Squillacioti , Giancarlo Bruno , Mirta Pinizzotto , Mendes Tribst João Paulo , Lo Giudice Roberto 
Published: September 2021

AbstractThe aim of this systematic review was to evaluate if the newly introduced bulk fill resin-based composite provides a better marginal sealing in cavity preparations with margins in dental cementum. The population investigation comparison outcome (PICO) framework was: in cavity preparation with margins in dental cementum of human extracted teeth, do bulk fill resin base composites provide a better marginal sealing than non-bulk fill resin-based composites? We performed our research on April 21, 2020. Two authors independently evaluated the abstract and titles for eligibility criteria. Two authors independently extracted the data and assessed the risk of bias in single studies. After the initial screening of 400 abstract and titles, the full text of the articles, that could meet the eligibility criteria, were obtained via the university library. A total of 36 full-text articles were evaluated; 11 articles were finally eligible for the review. Eight studies showed statistically differences, but not significant, in the marginal sealing between bulk fill and nonbulk fill resin-based composite (p > 0.05). One study showed statistically significant differences: SonicFill and Grandio showed better marginal sealing than GrandioSo and SDR(r) (Sirona Dentsply, New York, United States) and the latter two showed better marginal sealing than Filtek Supreme (p < 0.05). One study showed statistically significant less marginal gap of SDR than Filtek Bulk Fill (p = 0.0015) and Filtek Supreme (p < 0.0001). One study showed SDR to have a significantly higher microleakage than the other materials tested (p < 0.05). Based on our current literature review, there are not enough data to establish if bulk fill resin base composite provides a better or a worse marginal sealing at cementum margins.
Radiographic Findings in Flexion Instability after Total Knee Arthroplasty
Authors: Howie Cole M. , Mears Simon C. , Barnes C. Lowry , Mannen Erin M. , Stambough Jeffrey B. 
Published: September 2021

AbstractFlexion instability (FI) is one of the leading causes of knee pain and revision surgery. Generally, the biomechanical etiology is considered to be a larger flexion than extension gap. This may be due to mismatch of components sizes to the bone or malalignment. Other factors such as muscle weakness may also play a role, and the diagnosis of FI after total knee arthroplasty (TKA) relies on a combination of patient's complaints during stair descent or walking and physical examination findings. Our study examines the role of implant positioning and sizes in the diagnosis of FI. A retrospective review of 20 subjects without perceived FI and 13 patients diagnosed with FI after TKA was conducted. Knee injury and osteoarthritis outcome scores (KOOS) were documented, and postoperative radiographs were examined. Measurements including included tibial slope, condylar offset, femoral joint line elevation along with surrogate soft-tissue measures for girth and were compared between groups. The FI group was found to have a significantly lower KOOS score compared with the non-FI group (55.6 vs. 73.5; p = 0.009) as well as smaller soft-tissue measurements over the pretubercle region (6.0 mm vs. 10.6 mm; p = 0.007). Tibial slope, condylar offset ratios, and femoral joint line elevation were not significantly different between the FI and non-FI groups. We noted a significant difference in tibial slope in posterior-stabilized implants in subjects with and without FI (6.4° vs. 1.5°; p = 0.003). Radiographic measurements consistent with malalignment were not indicative of FI. X-ray measurements alone are not sufficient to conclude FI as patient symptoms, and clinical examinations remain the key indicators for diagnosis. Radiographic findings may aid in surgeon determination of an underlying cause for an already identified FI situation and help in planning revision surgery.
Predictive Clinical and Surgical Factors Associated with Recurrent Apoplexy in Pituitary Adenomas
Authors: Siu Alan , Rangarajan Sanjeet , Karsy Michael , Farrell Christopher J. , Nyquist Gurston , Rosen Marc , Evans James J. 
Published: September 2021

Abstract
Introduction Pituitary apoplexy is an uncommon clinical condition that can require urgent surgical intervention, but the factors resulting in recurrent apoplexy remain unclear. The purpose of this study is to determine the risks of a recurrent apoplexy and better understand the goals of surgical treatment.
Methods A retrospective chart review was performed for all consecutive patients diagnosed and surgically treated for pituitary apoplexy from 2004 to 2021. Univariate analysis was performed to identify risk factors associated with recurrent apoplexy.
Results A total of 115 patients were diagnosed with pituitary apoplexy with 11 patients showing recurrent apoplexy. This occurred at a rate of 2.2 cases per 100 patient-years of follow-up. There were no major differences in demographic factors, such as hypertension or anticoagulation use. There were no differences in tumor locations, cavernous sinus invasion, or tumor volumes (6.84 ± 4.61 vs. 9.15 ± 8.45 cm, p = 0.5). Patients with recurrent apoplexy were less likely to present with headache (27.3%) or ophthalmoplegia (9.1%). Recurrent apoplexy was associated with prior radiation (0.0 vs. 27.3%, p = 0.0001) and prior subtotal resection (10.6 vs. 90.9%, p = 0.0001) compared with first time apoplexy. The mean time to recurrent apoplexy was 48.3 ± 76.9 months and no differences in overall follow-up were seen in this group.
Conclusion Recurrent pituitary apoplexy represents a rare event with limited understanding of pathophysiology. Prior STR and radiation treatment are associated with an increased risk. The relatively long time from the first apoplectic event to a recurrence suggests long-term patient follow-up is necessary.
Developing shared languages
Authors: Whitehouse Marlies , Rahm Henrik , Wozniak Séverine , Breunig Steven , De Nardi Gianni , Dionne Frédérick , Fujio Misa , Graf Eva-Maria , Matic Igor , McKenna Christopher J. , Steiner Felix , Sviķe Silga 
Published: September 2021

Abstract
This issue of the AILA Review focuses on transdisciplinarity as the key to developing shared languages in and across domains and professional settings. The relationship and collaboration between researchers and practitioners have long been discussed within and across applied sciences and theoretical disciplines, mainly in the framework of transdisciplinarity (see AILA Review 31, 2018, for a recent overview). However, research approaches that claim to combine theoretical and practical needs and expectations often lack either solid grounding in empirical data or thorough reflection from theoretical perspectives. This special issue aims to take the discussion further by rethinking transdisciplinarity systematically from theoretical and practical angles. In so doing, we focus on developing shared languages that facilitate communication and mutual learning in multistakeholder discourses – with the ultimate goal of sustainably solving socially relevant problems. In the introduction, we present working definitions of our topic’s key terms (Part 1). We then go through the topics, results, and main interconnections of the six approaches examined in the papers included in this issue (Part 2). Based on the insights from the discussion so far, we set up a framework to systematically analyse three dimensions of developing shared languages: negotiation process, interplay of key drivers, and seizing opportunities (Part 3).
Analysing and optimising Informed Consent in cooperation with ethics committees and medical researchers
Authors: Matic Igor , De Nardi Gianni , Steiner Felix 
Published: September 2021

Abstract
Medical researchers are ethically and legally required to inform participants and get written permission before
enrolling them into a human research project (Informed Consent). Accordingly, information and consent represent a
complex procedure, and the participant concerned “must receive comprehensible oral and written information” (Swiss legislation:
Human Research Act (HRA) Art. 16). A triangle of stakeholders is involved in the procedure: ethics committees that review and
approve research projects and Informed Consent (IC) documents, medical researchers who produce the documents and
discuss enrolment with patients, and patients who have to be informed comprehensibly. From a linguistic point of view, the
question arises as to which perceptions of comprehensibility form the basis of the IC process and how shared language can be
established considering the complex relationship between these stakeholders. This contribution presents findings from two
perspectives (ethics committees and researchers) while considering the needs of all three stakeholders. Firstly, the
conceptualisation of comprehensibility among three ethic committees is presented, and steps toward harmonisation are outlined.
Secondly, limitations of how researchers conduct oral IC information are analysed, and the measures that were implemented to
improve patient information are discussed. A transdisciplinary approach is key in establishing these solutions because they do not
stem from linguistic analysis alone but have been developed in close collaboration with members of ethics committees and medical
researchers. Thus, the project shows how the expertise of applied linguistics in cooperation with practitioners can deliver an
important impact in both academic analysis and optimisation of professional procedures.
A Holistic and Globally Applicable Indication System for Regional Electric-Energy-Water Security
Authors: Landwehr Tobias , Schomberg Anna , Pahl-Wostl Claudia 
Published: September 2021

Abstract
The seventeen Sustainable Development Goals (SDGs) were designed to lead the modern Anthropocene to a lifestyle that was demanded by the Brundtland commission. Their objective is a common good that does not exploit the planet’s environment and is thus long-term. Though virtually separated, contemporary research shows that the seventeen SDGs are in- tertwined. This is also the case for water and energy (SDG 6 and 7). The present research offers the first holistic indicator set that is designed to demonstrate the synergies and trade-offs between electrical energy gener- ation and necessary water supply. It is founded on the SDG principles, follows a mindset based on the security definition established by Grey and Sadoff and is designed around the various technical dependencies of electrical energy and water. The set endeavors to reflect the manifoldness by which electrical energy is dependent on water supply in a dynamic eco- logic, economic and social environment. As electrical energy and water interactions are identified for a regional level, the set is designed to be applicable on any administrative or basin area with moderate data avail- ability. Thereby, the set includes industrializing and non-industrialized countries. It is based on six main indicators and sixteen sub indicators and seen as conceptual design for further discussion before application. The present paper argues and presents how those indicators are formed, why they are need, how and why they should be applied and why it is necessary if not inevitable to design cross-SDG indicators in a holistic view.