bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amyloid precursor protein localises to ependymal cilia in vertebrates and is required for ciliogenesis and brain development in zebrafish
Authors: Chebli Jasmine , Rahmati Maryam , Lashley Tammaryn , Edeman Birgitta , Oldfors Anders , Zetterberg Henrik , Abramsson Alexandra 
Published: June 2021

AbstractAmyloid precursor protein (APP) is ubiquitously expressed in human, mice and in zebrafish. In zebrafish, there are two orthologues, Appa and Appb. Interestingly, some cellular processes associated with APP overlap with cilia-mediated functions. Whereas the localization of APP to primary cilia ofin vitro-cultured cells has been reported, we addressed the presence of APP in motile and in non-motile sensory cilia and its potential implication for ciliogenesis using zebrafish, mouse, and human samples. We report that Appa and Appb are expressed by ciliated cells and become localized at the membrane of cilia in the olfactory epithelium, otic vesicle and in the brain ventricles of zebrafish embryos. App in ependymal cilia persisted in adult zebrafish and was also detected in mouse and human brain. Finally, we found morphologically abnormal ependymal cilia and smaller brain ventricles inappa-/-appb-/-mutant zebrafish. Our findings demonstrate an evolutionary conserved localisation of APP to cilia and suggest a role of App in ciliogenesis and cilia-related functions.
pUL21 regulation of pUs3 Kinase Activity Influences the Nature of Nuclear Envelope Deformation by the HSV-2 Nuclear Egress Complex
Authors: Muradov Jamil H. , Finnen Renée L. , Gulak Michael A. , Hay Thomas J. M. , Banfield Bruce W. 
Published: June 2021

AbstractIt is well established that the herpesvirus nuclear egress complex (NEC) has an intrinsic ability to deform membranes. During viral infection, the membrane-deformation activity of the NEC must be precisely regulated to ensure efficient nuclear egress of capsids. One viral protein known to regulate herpes simplex virus type 2 (HSV-2) NEC activity is the tegument protein pUL21. Cells infected with an HSV-2 mutant lacking pUL21 (ΔUL21) produced a slower migrating species of the viral serine/threonine kinase pUs3 that was shown to be a hyperphosphorylated form of the enzyme. Investigation of the pUs3 substrate profile in ΔUL21-infected cells revealed a prominent band with a molecular weight consistent with that of the NEC components pUL31 and pUL34. Phosphatase sensitivity and retarded mobility in phos-tag SDS-PAGE confirmed that both pUL31 and pUL34 were hyperphosphorylated by pUs3 in the absence of pUL21. To gain insight into the consequences of increased phosphorylation of NEC components, the architecture of the nuclear envelope in cells producing the HSV-2 NEC in the presence or absence of pUs3 was examined. In cells with robust NEC production, invaginations of the inner nuclear membrane were observed that contained budded vesicles of uniform size. By contrast, nuclear envelope deformations protruding outwards from the nucleus, were observed when pUs3 was included in transfections with the HSV-2 NEC. Finally, when pUL21 was included in transfections with the HSV-2 NEC and pUs3, decreased phosphorylation of NEC components was observed in comparison to transfections lacking pUL21. These results demonstrate that pUL21 influences the phosphorylation status of pUs3 and the HSV-2 NEC and that this has consequences for the architecture of the nuclear envelope.Author SummaryDuring all herpesvirus infections, the nuclear envelope undergoes deformation in order to enable viral capsids assembled within the nucleus of the infected cell to gain access to the cytoplasm for further maturation and spread to neighbouring cells. These nuclear envelope deformations are orchestrated by the viral nuclear egress complex (NEC), which, in HSV, is composed of two viral proteins, pUL31 and pUL34. How the membrane-deformation activity of the NEC is controlled during infection is incompletely understood. The studies in this communication reveal that the phosphorylation status of pUL31 and pUL34 can determine the nature of nuclear envelope deformations and that the viral protein pUL21 can modulate the phosphorylation status of both NEC components. These findings provide an explanation for why HSV-2 strains lacking pUL21 are defective in nuclear egress. A thorough understanding of how NEC activity is controlled during infection may yield strategies to disrupt this fundamental step in the herpesvirus lifecycle, providing the basis for novel antiviral strategies.
A juvenile climbing exercise establishes a muscle memory boosting the effects of exercise in adult rats
Authors: Eftestøl Einar , Ochi Eisuke , Solgård Juvkam Inga , Gundersen Kristian 
Published: June 2021

AbstractOne of the ideas stemming from the discovery of a cellular memory in muscle cells has been that an early exercise period could induce a long-term muscle memory, boosting the effects of exercise later in life. In general muscles are more plastic in younger animals, so we devised a 5-week climbing exercise scheme with food reward administered to juvenile rats (post-natal week 4-9). The juvenile exercise increased fiber cross-sectional area (fCSA), and boosted nuclear accretion. Subsequently the animals were subjected to 10 weeks of detraining (week 9-19, standard caging). During this period fCSA became similar in the animals that had been climbing compared to Naive controls, but the elevated number of myonuclei induced by the climbing were maintained. When the Naive rats were subjected to two weeks of adult exercise (week 19-21) there was little effect on fCSA, while the previously trained rats displayed an increase of 19%. Similarly, when the rats were subjected to unilateral surgical overload in lieu of the adult climbing exercise, the increase in fCSA was 20% (juvenile climbing group) and 11% (Naive rats) compared to the contralateral leg. This demonstrated that juvenile exercise can establish a muscle memory. The juvenile climbing exercise with food reward led to leaner animals with lower body weight. These differences were to some extent maintained throughout the adult detraining period in spite of all animals being fed ad libitum, indicating a form of body weight memory.
The cultural policies of a popular music venue: the case of Strasbourg's Espace Django
Authors: Costa Jacopo 
Published: June 2021

PurposeThis article discusses local cultural policies addressing popular music, and the values they imply, through a case study of Strasbourg's Espace Django, a publicly financed concert venue located in a disadvantaged neighborhood.Design/methodology/approachEspace Django's structural organization and overall cultural “philosophy” are described on the basis of field interviews and several documents related to the venue; they are then discussed in relation to literature on urban cultural policies and French policies concerning popular music.FindingsEspace Django's activities embody a will to improve social interactions within local communities. The venue does not fit in either the “music city” or the “creative cluster” theoretical model. However, its policies belong to the French institutional tradition of Développement Culturel, and they express a tendency toward eventification and the experience economy.Originality/valueIn France, the public sector plays an important role in cultural practices, mostly through funding and policymaking. The example of Espace Django adds a distinct French perspective to a research field mainly centered on Anglo-Saxon countries and more liberal economies. Also, the appendix on Espace Django's response to the coronavirus disease 2019 (COVID-19) health crisis adds interesting elements for understanding what are the successful choices in the current cultural scenario.
Benchmarking organisational innovativeness types for sustainability: a study of Indian firms
Authors: Bhupendra Kumar Verma , Sangle Shirish 
Published: June 2021

PurposeThe paper aims to explore the attributes and systemic characteristics of organisational innovativeness types in sustainability oriented firms in India. In dynamic business environment amid sustainability challenges, benchmarking organisational innovativeness of sustainability oriented firms may pave a way for many other firms to develop suitable strategies. The paper also presents the role of innovativeness in risk-management.Design/methodology/approachA questionnaire-based survey was conducted to gather the responses from 689 managers of 60 firms operating in India and displaying traits of sustainability orientation. Generic organisational innovativeness characteristics of these firms are presented based on result of factor analysis and variances explained by respective factors. Innovativeness characteristics have been discussed in context of sustainability and environmental management.FindingsStudy provides the glimpse of variability in steps taken by firms to remain competitive in current and future markets. The paper also offers a new factor of organisational innovativeness as “risk-innovativeness” and presents its role in disruptive and sustainable innovation.Research limitations/implicationsThe study adds to existing literature by providing a measure of organisational innovativeness types and proposes a definition of “risk-innovativeness” and opens a new avenue for further exploration.Practical implicationsThe study may help organisations operating in emerging economies to benchmark and develop attributes of organisational innovativeness types considering sustainability challenges and uncertain market conditions.Social implicationsThe study may guide other firms to benchmark their current innovativeness standing and may help in developing suitable attributes leading to combat negative impacts of climate change by developing sustainable innovations.Originality/valueThere are no existing studies which offer organisational innovativeness types of sustainability oriented firms, especially in emerging and developing economies context.
Construction time prediction model for public building projects
Authors: Alemu Shambel Kifle 
Published: June 2021

PurposeThe aim of the study was to develop a practical construction time model for public building projects in Addis Ababa, Ethiopia.Design/methodology/approachThis research work used regression analysis and also exploratory scatter and residual plot techniques. Simple and multiple regressions were used for the investigation of the best fit time model. The analyses were carried out using IBM SPSS statistical software, version 20.FindingsThe result revealed that the Bromilow time-cost principle was moderately applicable. However, the cubic regression model (CUB) was found a better time-cost relationship. On the contrary, the study has shown a poor relationship between actual time and gross floor area. Furthermore, multiple linear regression analysis (MLR) consists of three statistically significant variables were found a better fit time model.Research limitations/implicationsThe study is limited to only six project scope factors. Further research is recommended to include more building projects of similar type and implications of other factors to improve the reliability of the models.Practical implicationsThe developed model was not intended as a replacement for detailed construction scheduling techniques. The resulting model is applicable for front-end predictions of construction duration.Originality/valueThe main parties involved in the building projects should apply the model for benchmarking a precise construction time during the early planning phase.
Engagement, inclusion, knowledge sharing, and talent development: is reverse mentoring a panacea to all? Findings from literature review
Authors: Chaudhuri Sanghamitra , Park Sunyoung , Johnson Karen R. 
Published: June 2021

Purpose
The purpose of this study is to systematically review the practice of reverse mentoring and draw a timeline of the research over the past two decades. Considering the novelty of this intervention, this paper proposed an agenda for future research on this burgeoning topic.

Design/methodology/approach
By adopting narrative literature review and Gregory and Denniss’ (2018) four-step process, this paper reviewed 54 studies grounded in conceptual, literature review and empirical research published between 1998 and 2020.

Findings
The articles included in the literature review on reverse mentoring research were summarized according to journal publications, research methodologies, contextual settings, theoretical framework, purpose and outcomes. Reverse mentoring studies are dominantly published in educational journals using primarily qualitative and conceptual approaches to explore both academic and business contexts within the USA and Europe. Theories frequently used to frame and examine the need of reverse mentoring included social exchange theory and leader-member exchange theory. The fundamental purpose of reverse mentoring research is to transfer knowledge and to bridge the technology divide between intergenerational groups. Reverse mentoring has been used to promote inclusivity between multiple generations in relation to gender, ethnicity and culture.

Originality/value
As per the knowledge, this is the first-ever comprehensive English summary of reverse mentoring research done in the past two decades. Findings from this research can be used to better understand reverse mentoring research trends and directions.
Women directors and corporate performance: firm size and board monitoring as the least focused factors
Authors: Rahman Haseeb Ur , Zahid Muhammad 
Published: June 2021

PurposeThis paper aims to examine the impact of women directors on corporate performance (CP) and the mediating role of board monitoring in their relationship.Design/methodology/approachThe ordinary least squares with panel corrected standard errors are used as a primary estimator along with three other estimators to check the robustness of the estimations and address the potential endogeneity in a stratified random sample of 320 non-financial Malaysian companies listed on Bursa Malaysia (Stock Exchange) between 2010 and 2014.FindingsIt is found that women directors on the board not only improve firms’ return on assets but also reduce the volatility of their stocks. However, these findings are more applicable in small firms as compared to large firms. Besides, it is also noted the board monitoring significantly mediates the relationship between women directors and CP.Practical implicationsAs the monitoring role of women directors improves CP, substantial efforts may be put in to increase their meritorious representation on the boards. The regulators could pay equal attention to the small firms. Additionally, the number of board meetings may also be increased for strengthening the monitoring abilities of the board to improve CP.Originality/valueThe study contributes to the existing literature, as little attention has been paid to the mediation of board monitoring in the nexus of women directors and CP in the past.
Measuring volatility spillovers and asymmetric responses of Agri commodity prices: evidence from spices and rubber futures in India
Authors: Thazhugal Govindan Nair Saji 
Published: June 2021

Purpose
This paper aims to investigate price responses and volatility spillovers between commodity spot and futures markets. The study ultimately seeks the evidence-based claims on the efficiency of the long run and short run horizontal price transmissions from futures markets to spot markets.

Design/methodology/approach
This study used the most recent daily price series of pepper, cardamom and rubber, during the period 2004–2019, use “cointegration-ECM-GARCH framework” and verify the persisting validity of the “expectancy theory” of commodity futures pricing.

Findings
The results offer overwhelming evidence of futures market dominance in the price discoveries and volatility spillovers in spot markets. However, this paper finds asymmetric responses between cash and futures prices across markets. The hedging efficiency of futures contracts is commodities specific’ where spices futures are more efficient than the rubber futures.

Practical implications
The study passes on vital information to the producers and traders of spices and rubber who have a potential interest in the use of futures contracts to make profits from arbitrage between futures and cash markets.

Originality/value
The paper is unique in terms of understanding asymmetric price linkages in markets for plantation crops.
Financial literacy or investment experience: which is more influential in cryptocurrency investment?
Authors: Zhao Haidong , Zhang Lini 
Published: June 2021

PurposeThe purpose of this study was to investigate how financial literacy and investment experience impact cryptocurrency investment behavior and explore which factor is more influential in cryptocurrency investment.Design/methodology/approachUsing a sample of US individual investors from the 2018 National Financial Capability Study Investor Survey, a three-step hierarchical logistic regression was conducted following a model-comparison approach. In addition, a mediation analysis was conducted using the Karlson−Holm−Breen (KHB) method to further explore the mediating effect of investment experience between financial literacy and cryptocurrency investment.FindingsThis study found that while both financial literacy and investment experience were positively associated with investing in cryptocurrencies, investment experience was more influential in cryptocurrency investment. The findings also demonstrated that investment experience, especially risky asset holding, had a significant mediating effect between subjective financial knowledge and cryptocurrency investment behavior.Practical implicationsThe findings of this study offer insight to researchers by providing a deeper understanding of the determinants of cryptocurrency investment in the United States. This study also provides detailed implications for financial institutions, financial professionals and policymakers to guide rational cryptocurrency investment behavior.Originality/valueThis study is one of the initial attempts to explore the determinant factors in cryptocurrency investment, an area that has rarely been studied in the literature.
Energy analysis for construction of a zero-energy residential building using thermal simulation in Iran
Authors: Amani Nima , Reza Soroush Abdul Amir , Moghadas Mashhad Mostafa , Safarzadeh Keyvan 
Published: June 2021

Purpose
The purpose of this paper is to examine the feasibility and design of zero-energy buildings (ZEBs) in cold and semi-arid climates. In this study, to maximize the use of renewable energy, energy consumption is diminished using passive solar architecture systems and techniques.

Design/methodology/approach
The case study is a residential building with a floor area of 100 m2 and four inhabitants in the cold and semi-arid climate, northeast of Iran. For thermal simulation, the climate data such as air temperature, sunshine hours, wind, precipitation and hourly sunlight, are provided from the meteorological station and weather databases of the region. DesignBuilder software is applied for simulation and dynamic analysis of the building, as well as PVsyst software to design and evaluate renewable energy performance.

Findings
The simulation results show a 30% decrease in annual energy consumption of the building by complying with the principles of passive design (optimal selection of direction, Trombe wall, shade, proper insulation selection) from 25,443 kWh to 17,767 kWh. Then, the solar energy photovoltaic (PV) system is designed using PVsyst software, taking into account the annual energy requirement and the system’s annual energy yield is estimated to be 26,291 kWh.

Originality/value
The adaptive comparison of the values obtained from the energy analysis indicated that constructing a ZEB is feasible in cold and semi-arid conditions and is considered an effective step to achieve sustainable and environmentally friendly construction.
Green innovation a strategic resource to attain competitive advantage
Authors: Barforoush Nasrin , Etebarian Akbar , Naghsh Amirreza , Shahin Arash 
Published: June 2021

Purpose
Many industries accomplish green innovation for sustainable development, but it should play a significant role in the sustainable development and implementation of an organizations benefit. The purpose of this paper is to examine if green business innovation in terms of technology, organization, stakeholder and policies is able to develop competitive advantages.

Design/methodology/approach
This study was carried out in two stages and covered 4 variables and 21 indicators. Based on the experts’ opinions and literature review, a self-administered questionnaire was distributed among 113 experts of oil refining companies in Iran. The data were analyzed by the structural equation modeling technique.

Findings
The results indicated the effects of organizational factors, legislation, regulations and technology on green innovation. They also revealed the role of green innovation in reaching competitive advantages. Moreover, the relationship between stakeholder and green innovation was investigated.

Practical implications
The findings provide guidance on how firms can be better prepared for green innovation and get the most out of it and deal with the risks involved in green innovation, it is important that companies evaluate organization, technology and environment readiness and formulate corresponding strategies. Such a proactive approach can help enterprise control and minimize the risks of green innovation. A self-evaluation of the green innovation readiness of an enterprise helps the enterprise establish a mechanism to keep track of technological evolution.

Originality/value
This study contributes to the emerging field of green innovation which embed organization, technology, stakeholders, legislation and flows of the value created, delivered and captured in a value network. It also highlights the gaps in addressing the challenges of an innovative model for competitive advantages and suggests avenues for future research.