bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preexisting Mild Cognitive Impairment, Dementia, and Receipt of Treatments for Acute Ischemic Stroke
Authors: Levine Deborah A. , Galecki Andrzej T. , Morgenstern Lewis B. , Zahuranec Darin B. , Langa Kenneth M. , Kabeto Mohammed U. , Okullo Dolorence , Nallamothu Brahmajee K. , Giordani Bruno , Reale Bailey K. , Campbell Morgan , Lisabeth Lynda D. 
Published: April 2021

Background and Purpose:
Differences in acute ischemic stroke (AIS) treatment by cognitive status are unclear, but some studies have found patients with preexisting dementia get less treatment. We compared AIS care by preexisting cognitive status.

Methods:
Cross-sectional analysis of prospectively obtained data on 836 adults ≥45 with AIS from the population-based Brain Attack Surveillance in Corpus Christi project from 2008 to 2013. We compared receipt of a composite quality measure representing the percentage of 7 treatments/procedures received (ordinal scale; values, <0.75, 0.75–0.99, and 1.0), a binary defect-free quality score, and individual treatments after AIS between patients with preexisting dementia (Informant Questionnaire on Cognitive Decline in the Elderly score ≥3.44), mild cognitive impairment (MCI, score 3.1–3.43), and normal cognition (score ≤3).

Results:

Among patients with AIS, 42% had normal cognition (47% women; median age [interquartile range], 65 [56–76]), 32% had MCI (54% women; median age, 70 [60–78]), 26% had dementia (56% women; median age, 78 [64–85]). After AIS, 44% of patients with preexisting dementia and 55% of patients with preexisting MCI or normal cognition received defect-free care. Compared with cognitively normal patients, patients with preexisting MCI had similar cumulative odds (unadjusted cumulative odds ratio =0.99,
P
=0.92), and patients with preexisting dementia had 36% lower cumulative odds of receiving the composite quality measure (unadjusted cumulative odds ratio [OR]=0.64,
P
=0.005). However, the dementia-quality association became nonsignificant after adjusting for patient factors, namely sex, comorbidity, and body mass index (adjusted cumulative OR [acOR]=0.79,
P
=0.19). Independent of patient factors, preexisting MCI was negatively associated with receipt of IV tPA (intravenous tissue-type plasminogen activator; acOR=0.36,
P
=0.04), rehabilitation assessment (acOR=0.28,
P
=0.016), and echocardiogram (acOR=0.48,
P
<0.001). Preexisting dementia was negatively associated with receipt of antithrombotic by day 2 (acOR=0.39,
P
=0.04) and echocardiogram (acOR=0.42,
P
<0.001).

Conclusions:
Patients with preexisting MCI and dementia, compared with cognitively normal patients, may receive less frequently some treatments and procedures, but not the composite quality measure, after AIS.
Combining Concepts Across Categorical Domains: A Linking Role of the Precuneus
Authors: Rabini Giuseppe , Ubaldi Silvia , Fairhall Scott L. 
Published: April 2021

Abstract
The human capacity for semantic knowledge entails not only the representation of single concepts but the capacity to combine these concepts into the increasingly complex ideas that underlie human thought. This process involves not only the combination of concepts from within the same semantic category but frequently the conceptual combination across semantic domains. In this fMRI study (N = 24) we investigate the cortical mechanisms underlying our ability to combine concepts across different semantic domains. Using five different semantic domains (People, Places, Food, Objects, and Animals), we present sentences depicting concepts drawn from a single semantic domain as well as sentences that combine concepts from two of these domains. Contrasting single-category and combined-category sentences reveals that the precuneus is more active when concepts from different domains have to be combined. At the same time, we observe that distributed category selectivity representations persist when higher-order meaning involves the combination of categories and that this category-selective response is captured by the combination of the single categories composing the sentence. Collectively, these results suggest that the precuneus plays a role in the combination of concepts across different semantic domains, potentially functioning to link together category-selective representations distributed across the cortex.
Midlatitude Cloud Radiative Effect Sensitivity to Cloud Controlling Factors in Observations and Models: Relationship with Southern Hemisphere Jet Shifts and Climate Sensitivity
Authors: Grise Kevin M. , Kelleher Mitchell K. 
Published: April 2021

AbstractAn effective method to understand cloud processes and to assess the fidelity with which they are represented in climate models is the cloud controlling factor framework, in which cloud properties are linked with variations in large-scale dynamical and thermodynamical variables. This study examines how midlatitude cloud radiative effects (CRE) over oceans co-vary with four cloud controlling factors: mid-tropospheric vertical velocity, estimated inversion strength (EIS), near-surface temperature advection, and sea surface temperature (SST), and assesses their representation in CMIP6 models with respect to observations and CMIP5 models.CMIP5 and CMIP6 models overestimate the sensitivity of midlatitude CRE to perturbations in vertical velocity, and underestimate the sensitivity of midlatitude shortwave CRE to perturbations in EIS and temperature advection. The largest improvement in CMIP6 models is a reduced sensitivity of CRE to vertical velocity perturbations. As in CMIP5 models, many CMIP6 models simulate a shortwave cloud radiative warming effect associated with a poleward shift in the Southern Hemisphere (SH) midlatitude jet stream, an effect not present in observations. This bias arises because most models’ shortwave CRE are too sensitive to vertical velocity perturbations and not sensitive enough to EIS perturbations, and because most models overestimate the SST anomalies associated with SH jet shifts. The presence of this bias directly impacts the transient surface temperature response to increasing greenhouse gases over the Southern Ocean, but not the global-mean surface temperature. Instead, the models’ climate sensitivity is correlated with their shortwave CRE sensitivity to surface temperature advection perturbations near 40°S, with models with more realistic values of temperature advection sensitivity generally having higher climate sensitivity.
Measuring the Barriers to Adherence With Neurology Clinic Appointments for Children With Epilepsy: A Pilot Study
Authors: Bailey Jason , West Melanie , Agarwal Rajkumar , Kumar Gogi 
Published: April 2021

Introduction: Epilepsy is one of the most common neurological disorders in children. Missed appointments reflect missed opportunity to provide care for children with epilepsy. The objective of this study was to identify social determinants of health (SDH) and other factors associated with missed appointments in children with epilepsy and measure the relation between missed appointments and frequency of emergency room (ER) visits and inpatient admissions. Methods: This was a prospective study conducted in the neurology division at a level 4 epilepsy center. Children (0 to < 18 years of age) with a diagnosis of epilepsy were included and a semi-structured questionnaire was provided to the families. Patients with 2 or more missed neurology clinic appointments in the previous year (“study group”, n = 36) were compared to those with 1 or zero missed appointments (“control group”, n = 49). A comparison of the clinical characteristics, emergency room visits and hospitalizations in the past year as well as SDH was performed. Statistical analysis was performed using SPSS and p < 0.05 was considered significant. Results: The mean age, gender distribution and presence of medical refractoriness were comparable between the 2 groups. Families in the study group reported a higher likelihood of having to make special work arrangements for clinic appointments. Children in the study group were noted to have a significantly higher frequency of single mother households, presence of public insurance, father not graduating from high school and household income less than 50,000 dollars. Within the preceding year, children in the study group were noted to have a higher frequency of visits to the emergency department as well as 6 times higher likelihood of inpatient hospitalization for seizures. Conclusions: Social determinants of health play an important role in determining adherence with neurology clinic visits in children with epilepsy. Children with more missed appointments are likely to have a higher frequency of visits to the emergency department as well as a higher incidence of hospitalization for seizures. Identification of high-risk families and implementation of early interventions may improve adherence to office visits and decrease emergency room visits and hospitalization for seizures.
Modified STOP-Bang for predicting perioperative adverse events in the Thai population
Authors: Sangkum Lisa , Wathanavaha Chama , Tantrakul Visasiri , Pothong Munthana , Karnjanarachata Cherdkiat 
Published: April 2021

Abstract
Background
Undiagnosed obstructive sleep apnea (OSA) is associated with adverse perioperative outcomes. The STOP-Bang questionnaire is a validated screening tool for OSA. However, its precision may vary among different populations. This study determined the association between high-risk OSA based on the modified STOP-Bang questionnaire and perioperative adverse events.

Methods
This cross-sectional study included patients undergoing elective surgery from December 2018 to February 2019. The modified STOP-Bang questionnaire includes a history of Snoring, daytime Tiredness, Observed apnea, high blood Pressure, Body mass index > 30 kg/m2, Age > 50, Neck circumference > 40 cm, and male Gender. High risk for OSA was considered as a score ≥ 3.

Results
Overall, 400 patients were included, and 18.3% of patients experienced perioperative adverse events. On the basis of modified STOP-Bang, the incidence of perioperative adverse events was 23.2 and 13.8% in patients with high risk and low risk (P-value 0.016) (Original STOP-Bang: high risk 22.5% vs. low risk 14.7%, P-value 0.043). Neither modified nor original STOP-Bang was associated with perioperative adverse events (adjusted OR 1.91 (95% CI 0.99–3.66), P-value 0.055) vs. 1.69 (95%CI, 0.89–3.21), P-value 0.106). Modified STOP-Bang ≥3 could predict the incidence of difficult ventilation, laryngoscopic view ≥3, need for oxygen therapy during discharge from postanesthetic care unit and ICU admission.

Conclusions
Neither modified nor original STOP-Bang was significantly associated with perioperative adverse events. However, a modified STOP-Bang ≥3 can help identify patients at risk of difficult airway, need for oxygen therapy, and ICU admission.

Trial registrations
This study was registered on Thai Clinical Trials Registry, identifier TCTR20181129001, registered 23 November 2018 (Prospectively registered).
Crowdsourcing citation-screening in a mixed-studies systematic review: a feasibility study
Authors: Noel-Storr Anna H. , Redmond Patrick , Lamé Guillaume , Liberati Elisa , Kelly Sarah , Miller Lucy , Dooley Gordon , Paterson Andy , Burt Jenni 
Published: April 2021

Abstract
Background
Crowdsourcing engages the help of large numbers of people in tasks, activities or projects, usually via the internet. One application of crowdsourcing is the screening of citations for inclusion in a systematic review. There is evidence that a ‘Crowd’ of non-specialists can reliably identify quantitative studies, such as randomized controlled trials, through the assessment of study titles and abstracts. In this feasibility study, we investigated crowd performance of an online, topic-based citation-screening task, assessing titles and abstracts for inclusion in a single mixed-studies systematic review.

Methods
This study was embedded within a mixed studies systematic review of maternity care, exploring the effects of training healthcare professionals in intrapartum cardiotocography. Citation-screening was undertaken via Cochrane Crowd, an online citizen science platform enabling volunteers to contribute to a range of tasks identifying evidence in health and healthcare. Contributors were recruited from users registered with Cochrane Crowd. Following completion of task-specific online training, the crowd and the review team independently screened 9546 titles and abstracts. The screening task was subsequently repeated with a new crowd following minor changes to the crowd agreement algorithm based on findings from the first screening task. We assessed the crowd decisions against the review team categorizations (the ‘gold standard’), measuring sensitivity, specificity, time and task engagement.

Results
Seventy-eight crowd contributors completed the first screening task. Sensitivity (the crowd’s ability to correctly identify studies included within the review) was 84% (N = 42/50), and specificity (the crowd’s ability to correctly identify excluded studies) was 99% (N = 9373/9493). Task completion was 33 h for the crowd and 410 h for the review team; mean time to classify each record was 6.06 s for each crowd participant and 3.96 s for review team members. Replicating this task with 85 new contributors and an altered agreement algorithm found 94% sensitivity (N = 48/50) and 98% specificity (N = 9348/9493). Contributors reported positive experiences of the task.

Conclusion
It might be feasible to recruit and train a crowd to accurately perform topic-based citation-screening for mixed studies systematic reviews, though resource expended on the necessary customised training required should be factored in. In the face of long review production times, crowd screening may enable a more time-efficient conduct of reviews, with minimal reduction of citation-screening accuracy, but further research is needed.
Significant abnormal glycemic variability increased the risk for arrhythmias in elderly type 2 diabetic patients
Authors: Zhang Jianbo , Yang Jianmin , Liu Liwei , Li Liyan , Cui Jiangyin , Wu Shuo , Tang Kuanxiao 
Published: April 2021

Abstract
Background
Little is known about whether the influence of glycemic variability on arrhythmia is related to age in type 2 diabetes mellitus (T2DM). Therefore, we aimed to compare the association between glycemic variability and arrhythmia in middle-aged and elderly T2DM patients.

Methods
A total of 107 patients were divided into two groups: elderly diabetes mellitus group (EDM, n = 73) and middle-aged diabetes mellitus group (MDM, n = 34). The main clinical data, continuous glucose monitoring (CGM) and dynamic ECG reports were collected. The parameters including standard deviation of blood glucose (SDBG), largest amplitude of glycemic excursions (LAGE), mean amplitude of glycemic excursions (MAGE), absolute means of daily differences (MODD), time in range (TIR), time below range (TBR), time above range (TAR), coefficient of variation (CV) were tested for glycemic variability evaluation.

Results
In terms of blood glucose fluctuations, MAGE (5.77 ± 2.16 mmol/L vs 4.63 ± 1.89 mmol/L, P = 0.026), SDBG (2.39 ± 1.00 mmol/L vs 2.00 ± 0.82 mmol/L, P = 0.048), LAGE (9.53 ± 3.37 mmol/L vs 7.84 ± 2.64 mmol/L, P = 0.011) was significantly higher in EDM group than those of MDM group. The incidences of atrial premature beat, couplets of atrial premature beat, atrial tachycardia and ventricular premature beat were significantly higher in EDM group compared with the MDM group (all P < 0.05). Among patients with hypoglycemia events, the incidences of atrial premature beat, couplets of atrial premature beat, atrial tachycardia and ventricular premature beat (all P < 0.05) were significantly higher in the EDM group than those in the MDM group. In EDM group, TIR was negatively correlated with atrial tachycardia in the MAGE1 layer and with atrial tachycardia and ventricular premature beat in the MAGE2 layer, TBR was significantly positively correlated with atrial tachycardia in the MAGE2 layer (all P < 0.05). In MDM group, TAR was positively correlated with ventricular premature beat and atrial tachycardia in the MAGE2 layer (all P < 0.05).

Conclusions
The study demonstrated the elderly patients had greater glycemic variability and were more prone to arrhythmias. Therefore, active control of blood glucose fluctuation in elderly patients will help to reduce the risk of severe arrhythmia.
Clinical and radiographic variables related to implants with simultaneous grafts among type 2 diabetic patients treated with different hypoglycemic medications: a retrospective study
Authors: Shi Shaojie , Ding Feng , Liu Xiangdong , Wang Lei , Wang Xingxing , Zhang Sijia , Zhao Guoqiang , Song Yingliang 
Published: April 2021

Abstract
Background
The influence of different hypoglycemic agents on peri-implant variables among type 2 diabetes mellitus patients is still unclear. Therefore, the aim of this study was to assess the radiographic marginal bone loss and clinical parameters around implants in patients using different hypoglycemic agents.

Methods
In this retrospective cohort study, the dental implant records of type 2 diabetes mellitus patients who met the inclusion criteria were collected. The patients using only single medication as follows: insulin, metformin, or glucagon-like peptide-1 (GLP-1) drugs, were grouped according to their medication. These patients received implant placement with the same initial status, and all the prosthesis restorations were cement-retained ceramic crowns. The peri-implant marginal bone levels were evaluated by periapical radiographs immediately after implant placement and at 1 and 2-year follow-up visits. The baseline characteristics were compared among groups. The peri-implant radiographic marginal bone loss and clinical parameters were preliminarily compared using the Kruskal–Wallis test, and then the covariates were controlled by covariance analysis. Bonferroni post hoc adjustment test was performed for the multiple comparisons.

Results
After a review of more than 7000 medical records, a total of 150 patients with 308 implants at 1-year follow-up were assessed. The peri-implant marginal bone loss in the GLP-1 drug group was significantly smaller than the insulin group and metformin group (P < 0.01). The radiographic bone loss in the metformin group was higher than the insulin group (P < 0.05). Some of these included patients were lost to follow-up. Only 74 patients with 129 implants completed the 2-year follow-up. The radiographic bone loss in the metformin group was still higher than the insulin group (P < 0.05) and GLP-1 group (P < 0.01). There was no significant difference in the BOP (+) and the mean PD among groups (P > 0.05).

Conclusions
The radiographic variables were not exactly the same among the patients with different hypoglycemic agents at both the 1 and 2-year follow-ups. After ensuring consistency in baseline characteristics, the positive effect of GLP-1 drugs on peri-implant bone remodeling may be no less than insulin or metformin. More studies are needed to verify the direct effect of these drugs on peri-implant bone.
Clinical trial registration number ChiCTR2000034211 (retrospectively registered).
Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD
Authors: Pratte Katherine A. , Curtis Jeffrey L. , Kechris Katerina , Couper David , Cho Michael H. , Silverman Edwin K. , DeMeo Dawn L. , Sciurba Frank C. , Zhang Yingze , Ortega Victor E. , O’Neal Wanda K. , Gillenwater Lucas A. , Lynch David A. , Hoffman Eric A. , Newell John D. , Comellas Alejandro P. , Castaldi Peter J. , Miller Bruce E. , Pouwels Simon D. , Hacken Nick H. T. ten , Bischoff Rainer , Klont Frank , Woodruff Prescott G. , Paine Robert , Barr R. Graham , Hoidal John , Doerschuk Claire M. , Charbonnier Jean-Paul , Sung Ruby , Locantore Nicholas , Yonchuk John G. , Jacobson Sean , Tal-singer Ruth , Merrill Debbie , Bowler Russell P. 
Published: April 2021

Abstract
Background
Soluble receptor for advanced glycation end products (sRAGE) is a proposed emphysema and airflow obstruction biomarker; however, previous publications have shown inconsistent associations and only one study has investigate the association between sRAGE and emphysema. No cohorts have examined the association between sRAGE and progressive decline of lung function. There have also been no evaluation of assay compatibility, receiver operating characteristics, and little examination of the effect of genetic variability in non-white population. This manuscript addresses these deficiencies and introduces novel data from Pittsburgh COPD SCCOR and as well as novel work on airflow obstruction. A meta-analysis is used to quantify sRAGE associations with clinical phenotypes.

Methods
sRAGE was measured in four independent longitudinal cohorts on different analytic assays: COPDGene (n = 1443); SPIROMICS (n = 1623); ECLIPSE (n = 2349); Pittsburgh COPD SCCOR (n = 399). We constructed adjusted linear mixed models to determine associations of sRAGE with baseline and follow up forced expiratory volume at one second (FEV1) and emphysema by quantitative high-resolution CT lung density at the 15th percentile (adjusted for total lung capacity).

Results
Lower plasma or serum sRAGE values were associated with a COPD diagnosis (P < 0.001), reduced FEV1 (P < 0.001), and emphysema severity (P < 0.001). In an inverse-variance weighted meta-analysis, one SD lower log10-transformed sRAGE was associated with 105 ± 22 mL lower FEV1 and 4.14 ± 0.55 g/L lower adjusted lung density. After adjusting for covariates, lower sRAGE at baseline was associated with greater FEV1 decline and emphysema progression only in the ECLIPSE cohort. Non-Hispanic white subjects carrying the rs2070600 minor allele (A) and non-Hispanic African Americans carrying the rs2071288 minor allele (A) had lower sRAGE measurements compare to those with the major allele, but their emphysema-sRAGE regression slopes were similar.

Conclusions
Lower blood sRAGE is associated with more severe airflow obstruction and emphysema, but associations with progression are inconsistent in the cohorts analyzed. In these cohorts, genotype influenced sRAGE measurements and strengthened variance modelling. Thus, genotype should be included in sRAGE evaluations.