bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Value of Gut Microbiota to Predict Feed Efficiency and Growth of Rabbits Under Different Feeding Regimes
Authors: Velasco-Galilea María , Piles Miriam , Ramayo-Caldas Yuliaxis , Sánchez Juan P. 
Published: May 2021

Abstract
Gut microbiota plays an important role in nutrient absorption and could impact rabbit feed efficiency. This study aims at investigating such impact by evaluating the value added by microbial information for predicting individual growth and cage phenotypes related to feed efficiency. The dataset comprised individual average daily gain and cage-average daily feed intake from 425 meat rabbits, in which cecal microbiota was assessed, and their cage mates. Despite microbiota was not measured in all animals, consideration of pedigree relationships with mixed models allowed the study of cage-average traits. The inclusion of microbial information into certain mixed models increased their predictive ability up to 20% and 46% for cage-average feed efficiency and individual growth traits, respectively. These gains were associated with large microbiability estimates and with reductions in the heritability estimates. However, large microbiabililty estimates were also obtained with certain models but without any improvement in their predictive ability. A large proportion of OTUs seems to be responsible for the prediction improvement in growth and feed efficiency traits, although specific OTUs have a higher weight. Rabbit growth and feed efficiency are influenced by host cecal microbiota and considering microbial information in models improves the prediction of these complex phenotypes.
Influence of Cr2O3 Nanoparticles on the Structural, Optical, Thermal and Electrical Properties of PEO/CMC Nanocomposites
Authors: Gaabour Laila 
Published: May 2021

Abstract
In the present paper, different concentrations of chromium oxide (Cr2O3) nanoparticles were incorporated within PEO/CMC polymer blend to produce nanocomposite films using the casting method. The X-ray diffraction was performed on PEO/CMC-Cr2O3 nanocomposites. The main X-ray peaks of Cr2O3 were observed and defined as cubic structure and orthorhombic shape with an average particle size of the Cr2O3 ~ 50-80 nm. The decrease of some IR bands after the addition of Cr2O3 nanoparticles was found attributed to the interactions between PEO/CMC and Cr2O3. Effect of Cr2O3 nanoparticles on optical properties such as absorbance and optical energy gap (Eg) were characterized using UV-Vis spectroscopy. The Eg was reduced after the addition of Cr2O3 nanoparticles. The AC conductivity (sac), dielectric constant (ε′), dielectric loss (ε′′) and the dielectric modulus (M′ and M′′) were calculated at frequency range 0.1 Hz-7 GHz. The increases of direct conductivity (σdc) imply that the free charge density or of the charge mobility that results. The estimated values of both ε′ and ε′′ were decreased with increases of frequency. The addition of Cr2O3 nanoparticles causes the formation of a charge-transfer complex. The Cole-Cole plot between (M′ and M′′) shows a semi-circular shape confirm discuses according to a non‐Debye method.
Replantation of Spinous Process-lamina Complex in the Treatment of Cervical Spine Tumor : Two Cases Report and Literature Review
Authors: Jiahui Xu , Bin Ma , Chenggang Wang 
Published: May 2021

Abstract
Purpose: The primary aim of our study was to prove that the replantation of spinous process-lamina complex is beneficial to restore the anatomical structure and function of the spine, and to find if it can reduce postoperative complications.Methods: We report two cases of cervical intraspinal tumor, whose postoperative pathological diagnosis, Respectively, are Neurilemmoma and meningioma. They all underwent the resection and replantation of spinous process-lamina complex, in which the resected spinous process-lamina complex was replanted at the end of the procedure, allowing a complete reconstruction of the posterior element of the spinal canal. Results：After the surgery, the symptoms were relieved, and no dysfunction of upper limbs and sphincter was observed. The tumors were benign pathologically and were diagnosed as Neurilemmoma and meningioma. The patient recovered and at 6-month follow-up had no complaints and in good health.Conclusion: After tumor resection, the replantation of spinous process-lamina complex is beneficial to restore the anatomical structure and function of the spine.
Geological, Geomechanical and Geochemical Analysis on Claystone Of The Warukin Formation
Authors: Supandi Supandi 
Published: May 2021

Abstract
This study was conducted to determine the characteristics of Warukin claystone by carrying out 3G approach (geology – geomechanics and geochemistry). The aim of this is to provide the latest information on characteristics of Warukin claystone which may later be used for various purposes. Results of the study showed that the provenance of Warukin claystone was from recycled orogen. This was corroborated by the geochemical data which stated that the claystone was composed by clay-sized quartz minerals. Clay-sized quartz minerals indicate that there has been a long process of transport and weathering of the quartz minerals that have high resistance according to the Goldich series, until they become clay-sized. This finding has changed the paradigm so far that says that the Warukin claystone is composed of clay minerals, which is actually composed of clay-sized quartz minerals. The other geochemical data result is the absence of minerals from volcanic rocks that appear at the beginning of the Bowen series, which have fragile property. As a result of the recycled process, the fragile minerals were not found in claystone of the Warukin Formation. Mg is the fragile element that was not found and the mineral is an element binding in montmorillonite, so the presence of the montmorillonite in claystone of the Warukin Formation was also not found. Geomechanical data result shows that Warukin claystone had strength of around 100 kPa with internal friction angle of about 14° and cohesion of about 29 kPa. The results of 3G analysis had provided new answers that claystone of the Warukin Formations is composed by clay-sized quartz and the existence of montmorillonite is unlikely to be found in the Warukin Formation. Both of these corroborate the analysis that claystone of the Warukin Formation is from recycled orogen.
Exploration of Factors Influencing Traditional Chinese Medicine Doctor’s Competency Using Structural Equation Model
Authors: Wu Jinyi , Wang Xiaohe , Tao Qing , Mu Lan 
Published: May 2021

Abstract
Background Traditional Chinese medicine doctors have traditional advantages in the treatment of non-disease, basic medical treatment, chronic disease treatment, health care and rehabilitation. This research is to find the competency of TCM doctor using structural equation model and help to select proper candidate of TCM doctor. Results Based on the items extracted from competency theory, the data of 400 TCM doctors in Hangzhou, Guangzhou and Wuhan were identified by exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). On this basis, the interaction among the factors is analyzed, and the competency model is established by using the structural equation model (SEM). A total of 21 projects were identified as critical to TCM doctor capability, which were further tested and attributed to five factors: (1) professional value attitude; (2) basic medical knowledge; (3) communication skills; (4) clinical skills; (5) information management. The subsequent analysis shows that all factors have a significant impact on a person's ability, and ability contributes the most to the formation of a person's ability, while the intermediary role of personal characteristics and thinking can not be ignored in theory or practice. The results show that the competency model composed of these three factors has the same structure as the classic competency model. Conclusion This study presented a tentative approach for assessing clinical management assistant's competency, as well as emphasized to the managers the criteria to find and evaluate a TCM doctor.
Diagnostic Support System for the Detection of Attention Deficit Hyperactivity Disorder Using EOG Signals
Authors: Demirci Esra , Esas Mustafa Yasin , Altıntop Çiğdem Gülüzar , Taştepe Neslihan , Latifoğlu Fatma 
Published: May 2021

Abstract
Although Attention Deficit Hyperactivity Disorder (ADHD) is a common childhood disease, objective diagnostic methods are insufficient still. Current diagnostic methods include the subjective influence of the evaluator. In this context, in our study, we aimed to minimize the subjective effect of the evaluator with the objective diagnosis support system for ADHD.In our study, a visual stimulus follow-up test developed by us was applied to the patient with ADHD and healthy individuals, and electrooculogram (EOG) signals were recorded simultaneously. With the features extracted from EOG signals, Artificial Neural Networks (ANN) were used for the classification study of patients and healthy individuals, and it was determined that the classification of ADHD and healthy group could be distinguished by 81.76% performance. Thus, the outcomes that will contribute to the objective diagnosis of ADHD have been presented. The results are remarkable and important findings have been obtained that will contribute to the literature.
Analysis of The Fairness of Child Health Services In China 2010-2019
Authors: Wu Ji , Jin Hao-Nan , Lao Yi-Lei , Qu Xian-Guo 
Published: May 2021

Abstract
Background: The imbalance of child health services caused by the huge income gap between urban and rural residents and uncoordinated regional development has become increasingly prominent. This article analyzes the basic situation and equity of child care services in China from 2010 to 2019.Methods: Evaluate the equity of child health services by concentration index.Results: From 2010 to 2019, neonatal visit rate and system management rate of under-three children in Chinese child health service projects showed an upward trend, and the perinatal mortality rate decreased. The perinatal mortality rate is the highest in the western region, and the level of child health services in the central region is lower than the national average, but the gap between regions has gradually decreased. Child health services concentrate in provinces with high economic levels, and the perinatal mortality rate is the most unfair. Conclusion: The decline in the mortality rate of under-five children is related to the improvement in the child health services. We should improve the health services of perinatal infants and pay attention to the health of children aged 1 to 4 years. The fairness of child health service is affected by the two-child policy. We should rationally allocate resources and strengthen support for the central and western regions.
Development and Characterization of 37 SNP Markers For The Largemouth Bass (Micropterus Salmoides) By Using PCR-RFLP Method
Authors: Jiang Zhou , Cui Jiao , Shao Jiaqi , Dong Chuanju , Du Jinxing , Shen Yubang , Li Shengjie , Zhang Meng , Li Xuejun 
Published: May 2021

Abstract
Largemouth bass (Micropterus salmoides) is an economically important species in China. Contrary to its rapidly increasing yield during the last decades, the domestic genetic diversity of largemouth bass has gradually declined. For further rationally excavation and utilization of largemouth bass germplasm resources, 37 single nucleotide polymorphism (SNP) markers were developed based on genotyping-by-sequencing (GBS) data and characterized by genotyping 32 individuals using the PCR-RFLP method. The effective number of alleles (Ne), observed heterozygosity (Ho), expected heterozygosity (He), and polymorphic information content (PIC) of these SNPs ranged from 1.168 to 1.998, 0.156 to 0.844, 0.146 to 0.507, and 0.134 to 0.375, respectively. Totally, five loci deviated significantly from Hardy-Weinberg equilibrium (p < 0.05), while there existed no linkage disequilibrium at all loci. These novel polymorphic markers will lay the foundation for future population and conservation genetics of M. salmoides.
Two-Component Signal Transduction System VraSR Contributes to Neuroinflammation in Streptococcus Suis Meningitis
Authors: Dou Beibei , Yang Xia , Yang Fengming , Yan Kang , Peng Wei , Tang Jia , Peng Mingzheng , He Qiyun , Chen Huanchun , Yuan Fangyan , Bei Weicheng 
Published: May 2021

Abstract
Background: Streptococcus suis (S. suis) is an important zoonotic pathogen that can cause high morbidity and mortality in both humans and swine. As the most important life-threatening infection of the central nervous system (CNS), meningitis is an important symptom of S. suis infection. The VraSR is a critical two-component signal transduction system that affects S. suis ability to resist against host innate immune system and promotes the ability of S. suis to adhere to hBMEC. Whether and how VraSR contributes to the development of S. suis meningitis are currently unknown.Methods: The in vivo colonization, in vivo BBB permeability, histopathological examination and immunohistochemistry were applied to compare and characterize the degree of destruction of brain tissue in response to wild type SC19 and mutant ΔvraSR. Western blotting and real-time PCR were combined to identify the breakdown of tight junction proteins (TJ proteins). The secretion of proinflammatory cytokines and chemokines in the serum were detected on a BD FACSVerse flow cytometer.Results: We found an important role of VraSR regulatory system in S. suis SC19-induced meningitis. A mouse infection model demonstrated that ΔvraSR had significantly attenuated inflammatory lesions in the brain tissues compared with wild-type S. suis. In vitro, we characterized that SC19 could increase the blood-brain barrier (BBB) permeability through downregulating the TJ proteins compared with mutant ΔvraSR. Moreover, we found significant generation of proinflammatory cytokines and chemokines in the serum including IL-6, TNF-α, MCP-1, and IL-12p70 compared with ΔvraSR infected mice.Conclusions: For the first time, our work investigated the VraSR regulatory system of S. suis played an important role in streptococcal meningitis and revealed VraSR to be an important contributor to the disruption of TJ proteins. Characterization of these BBB disruption will facilitate further study of meningitis mechanisms in humans, thereby offering the development of novel preventative and therapeutic strategies against infection with S. suis.
Expression Characteristics and Clinical Significance of HMGB1 in Gastric Cancer: A Meta – Analysis
Authors: Zhang Xu , He Xiao-dong , Zhang You-cheng , Yang Ke-hu , Tian Jin-hui , Chen Yao-long 
Published: May 2021

Abstract
Objective: To clarify the expression of HMGB1 and its relationship with clinical features of gastric cancer.Methods: Multiple databases were systematically searched for relevant studies from 1997 to 2021. We screened case - control studies stating that the association between HMGB1 protein expression and clinical characteristics in gastric cancer.Results: In total, eight independent studies with 872 patients were included. Meta – analysis indicated higher odds of HMGB1 being present in gastric tumor tissues compared to para - tumor controls ［OR ＝ 4.15, 95％ CI (3.09, 5.58), P ＜ 0.01］. High HMGB1 expression was also associated with poor differentiation rate ［OR ＝ 0.73, 95％ CI (0.54, 0.99), P ＝ 0.04］, TNM stages Ⅲ - Ⅳ ［OR ＝0. 28, 95％ CI (0.18, 0.44), P ＜ 0.01］, lymphatic metastasis ［OR ＝ 2. 08, 95％ CI (1.52, 2.84), P ＜0.01］ and diffuse type of Lauren classification [OR ＝ 0.57, 95％ CI (0.38, 0.84), P ＜0. 01］. However, there was no significant correlation between HMGB1 expression between gender and age.Conclusion: Our results illustrated that HMGB1 protein was strongly associated with adverse clinicopathological features of gastric cancer. HMGB1 may be a promising target in the development of gastric cancer.
Design of Pill Filming System and Automatic Pill Classification System
Authors: Lee Juhui , Kwon Soyoon , Kim Jong Hoon , Kim Kwang Gi 
Published: May 2021

Abstract
Background Invent Pill classification system that can detect and classify into one tablet unit by deep-learning and Pill filming system that generate comprehensive and multi-dimensional data for learning.Methods Pill filming system and Pill classification system, they have two chapters consisted of structure design, model introduction, and controller design. Pill classification system's structure categorization is Input box, Linear conveyor, and Output box. In Data preprocessing, a similarity map is obtained with Structure Similarity Index Measure(SSIM). And RetinaNet is used as a pill classification learning model. Mean Accuracy Precision (mAP) is 0.9842, and we take experiment about measuring the number and accuracy of the classified pills for each experimenter's classification time. Conclusion Pill filming system and Pill classification system are expected to reduce labour losses for simple tasks. It helps medical personnel focus on significant and urgent tasks. And It can contribute to experiments about that deep-learning control the mechanical device.
Study Protocol for a Randomized Controlled Trial to Evaluate the Effectiveness of a Serious Game Targeting Interpersonal Emotion Regulation in Early Adolescents
Authors: Mittmann Gloria , Zehetmayer Sonja , Schrank Beate 
Published: May 2021

Abstract
Background: Adaptive interpersonal emotion regulation (iER) is a vital tool for positive relations. During early adolescence, peer relations become increasingly important, making this age group a relevant target group for interventions promoting positive interactions with each other, yet no evidence-based intervention exists for early adolescents specifically.Methods: This randomized controlled trial (RCT) aims to test effectiveness and feasibility of a serious game training iER skills in early adolescents by comparing outcomes with a control group playing a game without psychoeducational content in a pre- and post-test design. German- and English-speaking early adolescents (10-14 years) are eligible for participation. IER skills improvement as assessed by a vignette task is the primary outcome and will be analysed with a chi-square test. Secondary outcomes include feasibility and acceptability, emotional competence, personal emotion regulation, gender, and sex.Discussion: This RCT will test whether playing a serious game about iER strategies results in an improvement of iER skills and whether the game is feasible and acceptable for early adolescents with the ultimate aim to implement the game in schools and help early adolescents achieve positive peer relationships.Trial registration: ClinicalTrials.gov, NCT04808102, Registered 19 March 2021, https://register.clinicaltrials.gov/
Species Richness Interacts with Drought to Affect Litter Decomposition via its Effect on Litter Nitrogen Concentration
Authors: Wang Jiang , Ge Yuan , Cornelissen J. Hans C. , Wang Xiaoyan , Gao Song , Bai Yi , Chen Tong , Jing Zhongwang , Zhang Chongbang , Liu Wenli , Li Junmin , Yu Feihai 
Published: May 2021

Abstract
Biodiversity loss, exotic plant invasions and climatic change are currently the three major challenges to our globe and can each affect various ecological processes, including litter composition. To gain a better understanding of global change impacts on ecological processes, these three global change components need to be considered simultaneously. Here we assembled experimental plant communities with species richness levels (1, 2, 4, 8 or 16) and subjected them to drought (no, moderate or intensive drought) and invasion (invasion by the exotic annual plant Symphyotrichum subulatum or not). We collected litter of the native plant communities and let it decompose for nine months within the communities. Drought decreased litter decomposition, while the exotic plant invasion had no impact. Increasing species richness decreased litter decomposition under the mesic condition (no drought), but had little impact under moderate and intensive drought. A structural equation model showed that drought and species richness affected litter decomposition mainly via influencing litter nitrogen concentration, but not via altering the quantity and diversity of soil meso-fauna or soil physio-chemical properties. The negative impact of species diversity on litter decomposition under the mesic condition was mainly ascribed to a sampling effect, i.e. via particularly low litter nitrogen concentrations in the two dominant species. Our results indicate that species richness can interact with drought to affect litter decomposition via effect on litter nitrogen. We conclude that nitrogen-dependent litter decomposition should be a mechanism to predict integrated effects of plant diversity loss, exotic plant invasions and climatic change on litter decomposition.
The Efficacy and Safety of Fruquintinib Plus PD-1 Inhibitor in ≥3 line MSS Metastatic Colorectal Cancer Patients
Authors: Wang Xiangyi , lin li , liang jun 
Published: May 2021

Abstract
Purpose: Based on the suggestion of REGONIVO study, we reviewed the data of 26 MSS mCRC patients to elaborate the efficacy and safety of fruquintinib (a VEGFR inhibitor) plus PD-1 inhibitor and explore the potential predictors for survival in 3+ line microsatellite stable (MSS) metastatic colorectal cancer (mCRC) patients.Patients and methods: This retrospective study enrolled 26 MSS mCRC patients who progressed after at least 2 lines of systematic chemotherapy but didn’t receive PD-1 inhibitors. Fruquintinib of 3mg was administered once daily with 21 days on/7 days off plus PD-1 inhibitor 200mg every 3 weeks until intolerable toxicity or disease progression. Results: Median overall survival (mOS) was 6.1m (ranged 1.8m-NR 95%CI: 2.60-9.60); median progression free survival (mPFS) was 2.3m (ranged 1.5m-NR 95%CI: 0.93-3.67). There was one complete response (CR) and no partial response (PR). Stable disease was observed in 11 patients (42%) and progression disease (PD) was observed in 14 patients (54%). The object response rate (ORR) was 4% (1/26) and disease control rate (DCR) was 46 %( 12/26). Grade ≥3 AEs were observed in 5 patients (19.2%). Grade 5 AEs (immune related encephalitis and cardiotoxicity) were observed in 2 patients. Additionally, there was a significant correlation between NLR < 3.06 and longer survival (P=0.000) for MSS mCRC patients treated with fruquintinib plus PD-1 inhibitor. Conclusions: Fruquintinib plus PD-1 inhibitor may be a choice for 3+ line MSS mCRC patients，especially with pretreatment NLR<3.06.