bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacoinformatics-based identification of transmembrane protease serine-2 inhibitors from Morus Alba as SARS-CoV-2 cell entry inhibitors
Authors: Shakya Anshul , Chikhale Rupesh V. , Bhat Hans Raj , Alasmary Fatmah Ali , Almutairi Tahani Mazyad , Ghosh Surajit Kumar , Alhajri Hassna Mohammed , Alissa Siham A. , Nagar Shuchi , Islam Md Ataul 
Published: March 2021

Abstract
Transmembrane protease serine-2 (TMPRSS2) is a cell-surface protein expressed by epithelial cells of specific tissues including those in the aerodigestive tract. It helps the entry of novel coronavirus (n-CoV) or Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the host cell. Successful inhibition of the TMPRSS2 can be one of the crucial strategies to stop the SARS-CoV-2 infection. In the present study, a set of bioactive molecules from Morus alba Linn. were screened against the TMPRSS2 through two widely used molecular docking engines such as Autodock vina and Glide. Molecules having a higher binding affinity toward the TMPRSS2 compared to Camostat and Ambroxol were considered for in-silico pharmacokinetic analyses. Based on acceptable pharmacokinetic parameters and drug-likeness, finally, five molecules were found to be important for the TMPRSS2 inhibition. A number of bonding interactions in terms of hydrogen bond and hydrophobic interactions were observed between the proposed molecules and ligand-interacting amino acids of the TMPRSS2. The dynamic behavior and stability of best-docked complex between TRMPRSS2 and proposed molecules were assessed through molecular dynamics (MD) simulation. Several parameters from MD simulation have suggested the stability between the protein and ligands. Binding free energy of each molecule calculated through MM-GBSA approach from the MD simulation trajectory suggested strong affection toward the TMPRSS2. Hence, proposed molecules might be crucial chemical components for the TMPRSS2 inhibition.

Graphic abstract
Development and validation of a short version of the Sarcopenia Quality of Life questionnaire: the SF-SarQoL
Authors: Geerinck A. , Beaudart C. , Reginster J.-Y. , Locquet M. , Monseur C. , Gillain S. , Bruyère O. 
Published: March 2021

Abstract
Purpose
To facilitate the measurement of quality of life in sarcopenia, we set out to reduce the number of items in the previously validated Sarcopenia Quality of Life (SarQoL®) questionnaire, and to evaluate the clinimetric properties of this new short form.

Methods
The item reduction process was carried out in two phases. First, information was gathered through item-impact scores from older people (n = 1950), a Delphi method with sarcopenia experts, and previously published clinimetric data. In the second phase, this information was presented to an expert panel that decided which of the items to include in the short form. The newly created SFSarQoL was then administered to older, community-dwelling participants who previously participated in the SarcoPhAge study. We examined discriminative power, internal consistency, construct validity, test–retest reliability, structural validity and examined item parameters with a graded response model (IRT).

Results
The questionnaire was reduced from 55 to 14 items, a 75% reduction. A total of 214 older, community-dwelling people were recruited for the validation study. The clinimetric evaluation showed that the SF-SarQoL® can discriminate on sarcopenia status [EWGSOP2 criteria; 34.52 (18.59–43.45) vs. 42.86 (26.56–63.69); p = 0.043], is internally consistent (α = 0.915, ω = 0.917) and reliable [ICC = 0.912 (0.847–0.942)]. A unidimensional model was fitted (CFI = 0.978; TLI = 0.975; RMSEA = 0.108, 90% CI 0.094–0.123; SRMR = 0.055) with no misfitting items and good response category separation.

Conclusions
A new, 14-item, short form version of the Sarcopenia Quality of Life questionnaire has been developed and shows good clinimetric properties.
The poverty of manner categories in motion verbs coding vertical relations. Evidence from Polish and Russian
Authors: Łozińska Joanna 
Published: March 2021

AbstractThe article discusses the ways in which lexicalization of vertical motion takes place in two satellite-framed languages: Polish and Russian. In this typological category the manner of motion is typically rendered by the verb. The analysis of the descriptions of motion events by native speakers of these two genetically related languages shows that the lexicalization pattern of vertical motion differs from the horizontal one. First of all, when describing vertical relations, respondents less frequently code the manner of motion in the verb than when talking about motion along the horizontal plane. What is more, the results show that both Russian and Polish respondents use more motion verbs to describe vertical than horizontal relations, which points to the natural human tendency to code novel situations.
The Human Development Index with Multiple Data Envelopment Analysis Approaches: A Comparative Evaluation Using Social Network Analysis
Authors: Mariano Enzo Barberio , Ferraz Diogo , de Oliveira Gobbo Simone Cristina 
Published: March 2021

AbstractThe objective of this work is to use multiple Data Envelopment Analysis (DEA)/Benefit of the Doubt (BoD) approaches for the readjustment and exploitation of the Human Development Index (HDI). The HDI is the leading indicator for the vision of “development as freedom”; it is a Composite Index, wherein three dimensions (income, health, and education), represented by four indicators, are aggregated. The DEA-BoD approaches used in this work were: the traditional BoD; the Multiplicative BoD; the Slacks Based Measure (SBM) BoD; the Range Adjusted Model (RAM) BoD; weight restrictions; common weights; and tiebreaker methods. These approaches were applied to raw and normalized HDI data from 2018, to generate 40 different rankings for 189 countries. The resulting indexes were analyzed and compared using Social Network Analysis (SNA) and information derived from DEA itself (slacks, relative contributions, targets, relative targets and benchmarks). This paper presents useful DEA derived indexes that could be replicated in other contexts. In addition, it contributes by presenting a clearer picture of the differences between BoD models and offering a new way to appreciate the world's human development panorama.
When pursuing bad goals for good reasons makes it even worse: a social value approach to performance-avoidance goal pursuit
Authors: Świątkowski Wojciech , Dompnier Benoît 
Published: March 2021

AbstractConsistently in achievement goal research, pursuing performance-avoidance goals has been associated with a decrease in achievement. Less is known to what extent this effect depends on the reasons underlying these goals’ endorsement. The present research uses a social value approach to assess how do performance-avoidance goals’ effects on achievement depend on the reasons anchored in social utility (goal endorsed in order to succeed) and in social desirability (goal endorsed in order to please one’s teachers). Based on five correlational samples meta-analyzed in Study 1, results showed that perceiving performance-avoidance goals as socially useful increased the negative effect of these goals on achievement. This moderating effect was replicated experimentally in Study 2. These findings support the relevance of studying achievement goal complexes and illustrate that performance-avoidance goals may lead to deleterious consequences even when endorsed for seemingly good reasons.
Estimation of Health-State Utility Values and Factors Driving Health-Related Quality of Life in People Living with HIV and AIDS and Receiving cART in Germany: Baseline Analysis of a Cohort Study
Authors: Treskova Martina , Scholz Stefan , Kuhlmann Alexander , Mahlich Jörg , Stoll Matthias 
Published: March 2021

AbstractHIV has become a chronic disease since widespread of combined antiretroviral therapy (cART). Understanding the influence of therapeutic and preventive interventions on health-related quality of life (HRQoL) of people living with HIV and AIDS (PLWHA) is important. Information about health state utilities and HRQoL in PLWHA after the introduction of cART is limited, especially in Germany. The study aims to estimate and describe health state utilities and HRQoL in PLWHA in Germany and explore the effects of patient characteristics, clinical and treatment factors. Utilities and HRQoL in PLWHA in Germany were measured with the generic EQ-5D-3L questionnaire. Health state utilities were calculated based on the EQ-5D descriptive system using the German EQ-5D-3L time trade-off (TTO) value set. HRQoL was calculated based on the EQ visual analogue scale (EQ-VAS). Extensive descriptive analyses were performed to represent utility values for different groups of the patients. Generalized linear models (GLMs) with beta-inflated distributions were used to determine patient characteristics and clinical factors that influence TTO utilities and VAS scores. 1056 PLWHA completed the EQ-5D-3L questionnaires at the beginning of the study. The mean TTO utility value is 0.912 (SD ± 0.154), and the mean VAS HRQoL is 84.32 (SD ± 18.55). “Anxiety/depression” and “pain/physical discomfort” are the most affected dimensions. A longer period of living with HIV, a lower CD4-cell count, having symptomatic HIV or AIDS and an increased number of changes in therapy are associated with decreased utilities and a lower probability of having HRQoL of perfect health. No significant effect of duration of regimen was found. Depression significantly decreases TTO utility values. Higher education, full-time employment and female gender are associated with higher utilities. The resulted EQ-VAS values for PLWHA in Germany are comparable with EQ-VAS estimates for the general population. The obtained estimates can be used as inputs for health economic evaluations of HIV-interventions. Addressing anxiety and depression may reduce the quality of life impairment in PLWHA. Impact of comorbidities needs further investigation.
Gesundheitsverhalten und -förderung von ambulanten Pflegekräften
Authors: Neumann Felix Alexander , Mojtahedzadeh Natascha , Harth Volker , Mache Stefanie , Augustin Matthias , Zyriax Birgit-Christiane 
Published: March 2021

Zusammenfassung
Hintergrund
Prognosen zufolge werden im Jahr 2050 bis zu 0,85 Mio. Fachkräfte in der Pflege fehlen. Bereits heute führen zunehmende Arbeitsbelastungen zu hohen Krankenständen bei den Beschäftigten. Wissenschaftliche Erkenntnisse zum Gesundheitsverhalten bei ambulanten Pflegekräften fehlen, um zielgruppenspezifische Maßnahmen der betrieblichen Gesundheitsförderung (BGF) bereitstellen zu können.

Ziel der Arbeit
Ziel ist es, das Gesundheitsverhalten von ambulanten Pflegekräften sowie bestehende Angebote der BGF in der ambulanten Pflege zu charakterisieren und Erfahrungen der Expert*innen bei der Entwicklung und Implementierung von Maßnahmen BGF zu erfassen.

Material und Methoden
Zehn Expert*innen aus der Hamburger Pflegebranche und -wissenschaft wurden im Rahmen eines Fokusgruppeninterviews im Januar 2020 befragt. Die Datenauswertung fand mittels qualitativer Inhaltsanalyse statt.

Ergebnisse
Um selbstbestimmt und selbstständig mit der eigenen Gesundheit umzugehen, betonten die Experten, sei es besonders wichtig, die Pflegekräfte für die Themen Ernährung, körperliche Aktivität und Rauchen zu sensibilisieren. Für Stressbewältigung standen hingegen vermehrt verhältnispräventive Maßnahmen, wie realistische Fahrtenplanung, Arbeitszeitplanung und Anpassung der Pausenzeiten, im Fokus.

Schlussfolgerung
Die Arbeitsbedingungen der ambulanten Pflege wirken sich nachteilig auf das Ernährungs- und Trinkverhalten sowie die körperliche Aktivität bei den Beschäftigten aus. Weitere quantitative Erhebungen zum Gesundheitsverhalten werden benötigt, um die gewonnenen Einschätzungen der Expert*innen zu stärken. Zielgruppenspezifische Maßnahmen der BGF müssen an die ambulante Pflege angepasst sein und sowohl verhaltens-, als auch verhältnispräventive Ansätze einbeziehen.
High-affinity ammonium transport by Arabidopsis thaliana AMT1;4
Authors: Bindel Nino , Neuhäuser Benjamin 
Published: March 2021

AbstractIn plants high affinity transport proteins mediate the essential transport of ammonium across membranes. In Arabidopsis thaliana six of these AMmonium Transporters (AMTs) are encoded by the genome. All of them show a unique expression pattern. While most AMTs are highly expressed in the root, AtAMT1;4 expression is limited to the pollen grains and the pollen tube. Here, we addressed the transport characteristics of AtAMT1;4 in the heterologous Xenopus laevis oocytes system. The transport saturated and showed high affinity for ammonium with a Km value lower than 10 µM. Based on our electrophysiological analysis, we classified AtAMT1;4 as a high affinity ammonium transporter.
Mycotoxins in wheat cultivated in the Netherlands: results from eight years of field surveys
Authors: Van der Fels-Klerx H.J. , Focker Marlous , De Rijk Theo , Liu Cheng 
Published: March 2021

AbstractIn the period 2009–2018, an annual field survey with commercial arable farms in the Netherlands was held, to collect data on agronomics of wheat fields as well as mycotoxin concentrations of the specific wheat field at harvest. In total, 293 full farm field records over 8 years were obtained. This study aimed to investigate (i) the occurrence of deoxynivalenol (DON) and other mycotoxins, as well as correlations between these mycotoxins, and (ii) the relationships between agronomics and the DON concentration in wheat kernels for wheat cultivated in the Netherlands. Results showed that mycotoxins most frequently observed in concentrations above the limit of quantification were DON, enniatin B and B1, HT-2 toxin, zearalenone (ZEN) and nivalenol. On average, DON was detected in 54% of the samples (> 50 µg/kg) ranging from 19 to 92% depending on the year. Positive samples (> 50 µg/kg) had DON concentrations ranging 53–15,400 µg/kg, with a median of 228 µg/kg. Co-occurrence between DON and ZEN as well as between each of DON and ZEN with their modified forms was confirmed by the data of this study. The year influenced the DON concentration in wheat the most, followed by the region. The results of this study show that DON levels in wheat can only be influenced in a limited manner by agronomic practices such as the use of fungicides against Fusarium spp. around flowering, crop rotation, or the use of resistant wheat cultivars.
What Are Abstract Concepts? On Lexical Ambiguity and Concreteness Ratings
Authors: Löhr Guido 
Published: March 2021

AbstractIn psycholinguistics, concepts are considered abstract if they do not apply to physical objects that we can touch, see, feel, hear, smell or taste. Psychologists usually distinguish concrete from abstract concepts by means of so-calledconcreteness ratings. In concreteness rating studies, laypeople are asked to rate the concreteness of words based on the above criterion. The wide use of concreteness ratings motivates an assessment of them. I point out two problems: First, most current concreteness ratings test the intuited concreteness of word forms as opposed to concepts. This ignores the ubiquitous phenomenon of lexical ambiguity. Second, the criterion of abstract concepts that the instruction texts of rating studies rely on does not capture the notion that psychologists working on abstract concepts are normally interested in, i.e., concepts that could reasonably be sensorimotor representations. For many concepts that pick out physical objects, this is not reasonable. In this paper, I propose a characterization of concrete and abstract concepts that avoids these two problems and that may be useful for future studies in psychology.
Pediatric Primary Care Provider Comfort with Mental Health Practices: A Needs Assessment of Regions with Shortages of Treatment Access
Authors: Bettencourt Amie F. , Ferro Rebecca A. , Williams Jami-Lin L. , Khan Kainat N. , Platt Rheanna E. , Sweeney Sarah , Coble Kelly 
Published: March 2021

Abstract
Objectives
Nearly 50% of children with a mental health concern do not receive treatment. Child Psychiatry Access Programs like Behavioral Health Integration in Pediatric Primary Care (BHIPP) address regional shortages of mental health treatment access by providing training and consultation to primary care providers (PCPs) in managing mental health concerns. This study assessed PCPs’ comfort with mental health practices to inform expansion of BHIPP services.

Methods
Pediatric PCPs in 114 practices in three rural regions of Maryland were recruited to participate in a survey about their comfort with mental health practices and access to mental health providers for referral. Descriptives, Friedman’s test, and post hoc pairwise comparisons were used to examine survey responses.

Results
Participants were 107 PCPs. Most respondents were physicians (53.3%) or nurse practitioners/physician’s assistants (39.3%). Friedman’s test, χ2(7)= 210.15, p<.001, revealed significant within and between-group differences in PCP comfort with mental health practices. Post hoc pairwise comparisons indicated greater comfort providing mental health screening and referrals compared to prescribing psychiatric medications, providing psychoeducation or in-office mental health interventions. A Wilcoxon-signed rank test showed significantly more respondents agreed they could find a therapist than a psychiatrist in a timely manner, Z= −5.93, p<.001.

Conclusions
Pediatric PCPs were more comfortable with providing mental health assessment and referrals than treatment. However, PCPs reported difficulty finding therapists and psychiatrists for their patients. Findings underscore the need for longitudinal training to increase PCP comfort with mental health treatment. Additionally, strategies such as telepsychiatry are needed to address the disproportionate need for child psychiatrists.
13124 COVID-19: The Urgency of Engaging during Crisis
Authors: Bohn Krista , Croisant Sharon , Hallberg Lance , Prochaska John , Singleton Chantele 
Published: March 2021

ABSTRACT IMPACT: Throughout the COVID-19 pandemic, the UTMB Institute for Translational Sciences has sought to answer our communities’ needs for research, for knowledge of research, and involvement in research, while recognizing that meaningful engagement involves understanding all emergent needs and responding to maximize the health and well-being of those we serve. OBJECTIVES/GOALS: ITS community programs responsive to COVID-19 include:ο Ongoing communication with community and business stakeholdersο Social media and public health campaigns promoting safe practices, research updates, and testing informationο Community initiatives to increase testing among vulnerable populations METHODS/STUDY POPULATION: Like sister hubs across the US, the UTMB ITS has brought available resources to bear on addressing COVID-19 through research, medical response, and public health outreach. Community engagement activities have included facilitating communication, particularly by rapidly translating information for multiple audiences and wherever possible and appropriate, providing opportunities for the patient’s voice to inform and guide development of research. We realized the community’s need for trustworthy and reliable information about COVID-19 early in the pandemic. Key partnerships with community members and organizations were critical in enabling us all to be most responsive in meeting these needs. RESULTS/ANTICIPATED RESULTS: ITS community outreach included developing infographics, media notices, and educational materials related to prevention and testing as well as appropriate use of PPE. These efforts resulted in an article in a regional newspaper, which was disseminated widely through social media networks. ITS faculty also engaged doctoral and MPH trainees to support the Health District’s contact tracing effort. We held several events on mental health impacts as well as discussions related to health disparities. Both activities shaped plans for community-based interventions and research. The ITS also hosted a virtual workshop to facilitate discussion around key research questions related to the pandemic. DISCUSSION/SIGNIFICANCE OF FINDINGS: Throughout the pandemic, the ITS has maintained contact with stakeholders. Our roles have been to communicate, disseminate, translate, provide resources, and build bridges. We also listen, share, and provide opportunities for patients and communities to engage in all phases of the research spectrum.
55484 Dual activation of CAR and Nrf2 improves the efficacy: toxicity ratio of cyclophosphamide and doxorubicin-based treatment of TNBC
Authors: Stern Sydney , Liang Dongdong , Li Linhao , Kurian Ritika , Lynch Caitlin , Heyward Scott , Kareem Ajoke , Chun Young , Hong Charles , Xue Fengtian , Wang Hongbing 
Published: March 2021

ABSTRACT IMPACT: Triple negative breast cancer (TNBC) affects 10-20% of women with breast cancer and is biologically more aggressive than other subtypes. The novel compound we have developed, DL7076, would give clinicians a vital strategy to improve the commonly used cyclophosphamide (CPA) and doxorubicin (DOX) regimen in the treatment of TNBC. OBJECTIVES/GOALS: The objective of this research project is to develop a novel compound which can activate both 1) the constitutive androstane receptor (CAR) and subsequently enhance the CYP2B6-mediated activation of CPA, and 2) the nuclear factor erythroid- related factor-2 (Nrf2) leading to the cardiomyocyte protection from DOX-associated cardiotoxicity. METHODS/STUDY POPULATION: Following the identification of the compound candidate, DL7076 was evaluated for tissue specific induction of CAR and Nrf2 using qPCR, western blot analysis, and luciferase reporter assays.Further, we have developed a multicellular coculture model incorporating human primary hepatocytes for metabolism, TNBC spheroids as the target, and cardiomyocytes as a side target of DOX. We have investigated the anticancer effects of CPA/DOX on TNBC cells and the toxic effects on cardiomyocytes with/without a CAR-Nrf2 activator, in a multicellular environment where hepatic metabolism is well-retained. RESULTS/ANTICIPATED RESULTS: We found that our dual activator of CAR and Nrf2, DL7076, exhibits tissue specific induction of CAR and Nrf2. Inclusion of DL7076 in combination with the CPA/DOX regimen improves anticancer efficacy, through the subsequent increase in the formation of the active CPA metabolite. With the addition of DL7076, DOX-mediated off-target cardiotoxicity was markedly reduced.Lastly, utilizing the novel coculture system with human primary hepatocytes, TNBC spheroids, and cardiomyocytes, the inclusion of DL7076 to the CPA/DOX regimen shows decreased spheroid viability and improved cardiomyocyte viability and function. DISCUSSION/SIGNIFICANCE OF FINDINGS: Our findings suggest that DL7076 can facilitate DOX/CPA containing regimens by increasing CAR-mediated metabolism and subsequent CPA bioactivation while selectively protecting cardiomyocytes from DOX-induced toxicity. This research is expected to translate our basic scientific findings into therapeutic interventions for women with TNBC.