bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efektivitas Akupresur dan Prenatal Yoga terhadap Penurunan Nyeri Punggung Bawah Ibu Hamil Trimester III di Wilayah Kerja Puskesmas Telagasari
Authors: Masluroh Masluroh , Sutinah Titin 
Published: December 2024

ABSTRACT During the third trimester of pregnancy, many pregnant mothers experience complaints or discomfort, one of which is lower back pain as the fetal weight increases and the uterus grows. An attempt to alleviate the mother's lower back pain could be with alternative therapies with acupressure and prenatal yoga. The aim of this survey is to find out how the effectiveness of acupressure and prenatal yoga to the reduction of lower back pain in pregnant mothers of the third trimester in the Public Health Center of Telagasari working region in 2024. The results of the study can be interpreted that pregnant women who had reduced levels of pain after doing Yoga had more respondents who had no pain, most of whom had 11 (73.3%) respondents, while mothers who did Acupressure had 9 (60.0%) respondents. So the results of data analysis use the paired simple t test. The resulting value and ρ-value were 0.000<0.05. Pregnancy yoga exercises (Prenatal Gentle Yoga) are part of non-pharmacological therapy that can reduce pain. Yoga exercises carried out in the third trimester of pregnancy can reduce complaints felt by pregnant women during the third trimester, one of which is back pain. Keywords: Prenatal Yoga, Acupressure, Back Pain ABSTRAK Selama trimester ketiga kehamilan, banyak ibu hamil yang mengalami keluhan atau ketidaknyamana, salah satunya nyeri punggung bagian bawah ini karena berat badan janin meningkat dan rahim ibu makin membesar. Upaya untuk mengurangi nyeri punggung bagian bawah ibu tersebut bisa dengan pengobatan alternatif dengan akupresur dan prenatal yoga. Tujuan peneltian ini untuk mengetahui bagaimana efektivitas akupresur dan prenatal yoga terhadap penurunan nyeri punggung bawah ibu hamil trimester III di wilayah kerja puskesmas telagasari tahun 2024. Metode penelitian ini menggunakan quasi eksperimen dengan 30 responden teknik pengambilan data menggunakan tekhnik purposive sampling. Hasil penelitian dapat diinterpretasikan bahwa ibu hamil yang pengurangan tingkat nyeri setelah melakukan Yoga mempunyai lebih banyak responden yang Tidak nyeri sebagian besar dengan jumlah responden 11 (73,3%) , sedangkan ibu yang melakukan Akupresur dengan jumlah responden 9 (60,0%). Jadi hasil analisa data menggunakan uji paired simple t test. didapatkan hasil nilai dan ρ-value 0,000<0,05. Senam yoga kehamilan (Prenatal Gentle Yoga) merupakan bagian dari terapi non farmakologis yang dapat menurunkan nyeri. Senam yoga yang dilakukan pada kehamilan trimester III dapat mengurangi keluhan yang dirasakan ibu hamil selama trimester III salah satunya yaitu nyeri punggung. Kata Kunci: Prenatal Yoga, Akupresure, Nyeri Punggung
Pengembangan Instrumen Skala Kemampuan Komunikasi Interpersonal Pada Mahasiswa Pendidikan Guru Pendidikan Anak Usia Dini
Authors: Sari Yulia Novita , Fajhriani N Dyla , Arfa Umikalsum , Jariah Nurul , Sultoni Agus 
Published: December 2024

Penelitian ini bertujuan untuk mengembangkan instrumen skala kemampuan komunikasi interpersonal sehingga menghasilkan instrumen yang valid dan reliabel dalam mengukur tingkat kemampuan komunikasi interpersonal pada mahasiswa. Penelitian ini menggunakan metode Research and Development (RD). Subjek dalam penelitian ini adalah 32 mahasiswa semester tujuh. Hasil uji validitas dengan menggunakan dua cara, yaitu validitas konstruk (construct validity) dan validitas isi (content validity). Pada hasil uji validitas dihasilkan 29 item pernyataan valid dan 11 item pernyataan tidak valid. Selanjutnya dilakukan uji reliabilitas dengan nilai Cronbach’s Alpha 0,910 yang memiliki kualifikasi reliabilitas yang sangat tinggi. Dengan demikian, instrumen siap digunakan. Berdasarkan hasil uji validitas dan reliabilitas tersebut, instrumen kemampuan komunikasi interpersonal pada mahasiswa yang dikembangkan telah memenuhi kriteria validitas serta termasuk ke dalam kategori validitas dan reliabilitas sangat tinggi, sehingga instrumen skala kemampuan komunikasi interpersonal pada mahasiswa dapat dikatakan layak untuk mengukur tingkat kemampuan komunikasi interpersonal.
Chemistry Profile and Biological Activity of Campnosperma auriculatum Extracts
Authors: MUHARINI RINI , LESTARI IRA , ERSANDO  , MASRIAN  , PUTRI YANA AISYA , GERINA FEBRILIA , OLA ANTONIUS RB 
Published: December 2024

As our ongoing investigation for bioactive natural products from tropical plant, we performed preliminary study on one of important tropical plants in West Kalimantan, Terentang putih, Campnosperma auriculatum. The aims were to determine effective solvent used for extraction, chemistry profile, total phenolic content, free-radical scavenging, cytotoxicity, and anti-termite activities of leaves, stems, and roots extracts of C. auriculatum. Variation of solvent for extraction was selected based on its polarisation, namely, ethanol, ethyl acetate, and n-hexane. The effectiveness of solvent was determined by observing the rendemen of each extract, where amount of sample and solvent volume, duration of extraction, temperature, and maceration technique were controled. Determination of total phenolic content was performed using Folin-Ciocalteu method. IC50 value for free-radical scavenging activity was calculated by plotting standard concentration and absorption data observed through DPPH method. Cytotoxicity evaluation was performed to each ethanolic extract against 4T1 cancer cell line using MTT assay. Anti-termite activity was conducted against Coptotermes curvignathus by calculating percentage of termite mortality and paper weight loss. This research showed that ethanol solvent was the most effective extraction solvent giving the highest yield in each part of plant. Phytochemically, all extracts showed that they contain phenolics and alkaloids. Ethanolic extract of stems showed the highest total phenolic content with 737.6 ± 0.56 ppm (GAE) and the most active as free-radical scavenger with IC50 value of 135.51 ± 0.91 ppm. Meanwhile, the roots extract exhibited pronounce cytotoxicity toward 4T1 cancer cell line with IC50 value of 1.55 ± 3.29 µg/ml and high selectivity index. Furthermore, the roots extract displayed most active as anti-termite as well as antifeedant. Hitherto, this study is the first report on phytochemistry and biological activity from leaves, stems, and roots of C. auriculatum. Moreover, this plant can be explored further for its potential on medicinal and agricultural industries.
An Examination of The Role of Psychological Empowerment on Entrepreneurial Success: Evidence of Women Entrepreneurs in Semarang City
Authors: Sugiyanto Eviatiwi Kusumaningtyas , Wijayanti Ratna , Damajanti Anita , Arif Muhammad , Shujahat Ali 
Published: December 2024

Purpose – This study aims to review empirical data on the effect of empowerment on performance at the individual level. It investigates the aspects of empowerment and how they affect a female entrepreneur’s ability to succeed.
Methodology – We collected 96 female entrepreneurs in Semarang City participated in this study. Data was gathered using a Google form link questionnaire. The data was analyzed using the WrapPLS 8.0 software and the structural equation modelling (SEM) technique.
Findings – The findings showed that women’s success as entrepreneurs is influenced by all three aspects of psychological empowerment: self-determination, competence, and impact. However, the meaning dimension does not affect women’s entrepreneurial success.
Originality – Based on the body of knowledge from previous research, there is a population gap. The originality of this research is to consider the object that has not been studied in previous studies, that is, women entrepreneurs.
Triglycerides to apolipoprotein A1 ratio: an effective insulin resistance-associated index in identifying metabolic dysfunction-associated fatty liver disease in type 2 diabetes mellitus
Authors: Wang Wei , Chen Yang , Tu Mei , Chen Hang Ju 
Published: December 2024

BackgroundThe triglycerides to Apolipoprotein A1 ratio (TG/APOA1) holds promise to be a more valuable index of insulin resistance for the diagnosis of metabolic dysfunction-associated fatty liver disease (MAFLD) in type 2 diabetes mellitus (T2DM). This study aims to evaluate the correlation between TG/APOA1 and MAFLD, as well as compare the efficacy of TG/APOA1 with triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-c) and triglyceride-glucose (TyG) index in identifying MAFLD among individuals with T2DM.MethodThis study consecutively recruited 779 individuals with T2DM for the investigation. The unenhanced abdominal CT scans were conducted to measure CT liver-spleen attenuation measurement (CTL-S). The CTL-S less than 1.0 and without other liver comorbidities were considered to be MAFLD. The binomial logistic regression analysis and restricted cubic spines (RCS) were employed to evaluate the association between TG/APOA1 and MAFLD. The receiver operating characteristic (ROC) curve analysis was performed to compare the efficacy of TG/APOA1 with TG/HDL-c and TyG index identifying MAFLD.ResultsThe TG/APOA1 exhibited a substantial increase in the MAFLD group (P&lt;0.05). Even after adjustments for potential confounding factors, TG/APOA1 exhibited significant associations with nonalcoholic fatty liver disease fibrosis score (β=0.266, P&lt;0.001), fibrosis-4 index (β=0.123, P=0.029), aspartate aminotransferase-to-platelet ratio index (β=0.113, P=0.037), and CTL-S (β=-0.225, P&lt;0.001). Meanwhile, TG/APOA1 contributed to an independent variable for MAFLD, the odds ratio with a 95% CI was 2.092 (1.840-2.380) in the total population, 2.123 (1.810-2.511) in men, and 2.162 (1.824-2.587) in women. Additionally, the results also revealed a nonlinear association between elevated TG/APOA1 and higher MAFLD risk according to the RCS analysis whether in the total population, men, or women (P for nonlinearity and overall &lt;0.001). Furthermore, TG/APOA1 had higher AUC level compared to TG/HDL-c and TyG index in the total population (0.769 vs 0.742, P=0.025; 0.769 vs 0.694, P &lt; 0.001), men (0.776 vs 0.744, P=0.044; 0.776 vs 0.709, P &lt; 0.001), and women (0.762 vs 0.728, P=0.041; 0.762 vs 0.674, P &lt; 0.001).ConclusionTG/APOA1 serves as an effective index of insulin resistance in identifying MAFLD, offering advantages in the screening of MAFLD in T2DM.
The incidences of postoperative hypoparathyroidism during thyroid surgery with ipsilateral central lymph node dissection for papillary thyroid carcinoma were close to that during thyroid surgery for benign thyroid diseases necessitating surgical intervention: a retrospective study
Authors: Wang Bin , Zhu Chun-Rong , Fei Yuan , ShanZhou Qiyue , Liu Hong , Yao Xin-Min , Wu Jian 
Published: December 2024

ObjectiveThis study aimed to assess the degree of effect of central lymph node dissection on postoperative hypoparathyroidism incidence.MethodsThe incidence of postoperative hypoparathyroidism was compared between patients receiving thyroidectomy with central neck dissection for papillary thyroid carcinoma and those undergoing thyroidectomy for benign thyroid diseases (thyroid follicular adenoma and/or nodular goiter) necessitating surgical intervention.ResultsThe incidence of postoperative hypoparathyroidism was not significantly different between the groups of lobe thyroidectomy for benign thyroid diseases and lobe thyroidectomy with ipsilateral central lymph node dissection for papillary thyroid carcinoma (immediate: 9.2% vs 3.0%, P = 0.157; protracted: 4.6% vs 0%, P = 0.06; permanent: 0% vs 0%). Similarly, there was no significant difference in the postoperative hypoparathyroidism incidence between total thyroidectomy for benign thyroid diseases and total thyroidectomy with ipsilateral central lymph node dissection for papillary thyroid carcinoma (immediate: 25.0% vs 33.8%, P = 0.12; protracted: 4.5% vs 5.3%, P = 0.99; permanent: 1.1% vs 0.9%, P &gt; 0.99).ConclusionWhile the rates of postoperative hypoparathyroidism during thyroid surgery with ipsilateral central lymph node dissection may be slightly elevated compared to surgery without it for papillary thyroid carcinoma, they remained akin to those observed during surgery for benign thyroid diseases that need surgical management.
Enhancing cell-mediated immunity through dendritic cell activation: the role of Tri-GalNAc-modified PLGA-PEG nanoparticles encapsulating SR717
Authors: Gong Yang , Jia Hongbin , Dang Wenrui , Zhou Ting , He Pu , Wang Xiaolei , Zhu Bingdong 
Published: December 2024

IntroductionVaccines against intracellular pathogens like Mycobacterium tuberculosis (M. tuberculosis) require the induction of effective cell-mediated immunity. Adjuvants primarily enhance antigen-induced adaptive immunity by promoting the activation of antigen-presenting cells (APCs).This study is to develop an adjuvant targeted to dendritic cells (DCs), one of the main APCs, so as to assist in inducing a long-term cellular immune response to M. tuberculosis protein antigens.MethodsPolylactic-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles (NPs) modified with Triantennary N-Acetylgalactosamine (Tri-GalNAc) were prepared to target DCs. Additionally, the stimulator of interferon genes (STING) agonist SR717 was encapsulated within PLGA-PEG NPs to activate DCs. Meanwhile, M. tuberculosis fusion protein (TP) was encapsulated in PLGA-PEG NPs to construct vaccine candidates: TP/Tri-GalNAc-PLGA-PEG-SR717 (TP/GPS in short) and TP/ Tri-GalNAc-PLGA-PEG (TP/GP in short). The targeting and activation effects of these NPs were assessed in vitro and in vivo, and their immunogenicity were evaluated in mice.ResultsTri-GalNAc modification significantly enhanced the targeting of NPs to DCs, and encapsulated SR717 effectively promoted the maturation and activation of DCs. TP/GPS elicited a potent antigen-specific T cell immune response and successfully induced long-term immune memory in mice. Moreover, after the mice were infected with H37Ra via nasal instillation, TP/GPS significantly reduced the bacterial load in their lungs.DiscussionTri-GalNAc-modified PLGA-PEG NPs in combination with SR717 targeted and activated DCs, effectively assisting M. tuberculosis antigen in inducing long-term T cell-mediated immunity. This approach offers an innovative and effective adjuvant strategy for the development of subunit vaccine against intracellular pathogen.
Prediction of preoperative peritoneal cancer index for pseudomyxoma peritonei by multiple linear regression analysis
Authors: Bai Mingjian , Feng Jing , Liu Jie , Li Yunxiang , Xu Yueming , Ma Fucun , Ma Ruiqing , Liang Guowei , Liu Xuekai , Zhao Na 
Published: December 2024

BackgroundThe aim of the present study was to establish a predictive model to predict the peritoneal cancer index (PCI) preoperatively in patients with pseudomyxoma peritonei (PMP).MethodsA total of 372 PMP patients were consecutively included from a prospective follow-up database between 1 June 2013 and 1 June 2023. Nine potential variables, namely, gender, age, Barthel Index (BAI), hemoglobin (Hb), albumin (Alb), D-dimer, carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA 125), and CA 19-9, were estimated using multiple linear regression (MLR) analysis with a stepwise selection procedure. The established MLR model was internally validated using K-fold cross-validation. The agreement between the predicted and surgical PCI was assessed using Bland–Altman plots and intraclass correlation (ICC). A p-value of less than 0.05 was considered statistically significant.ResultsSix independent predictors were confirmed by the stepwise MLR analysis with an R2 value of 0.570. The predicted PCI formula was represented as follows: PCI = 19.567 + 2.091 * Gender (male = 1, female = 0) − 0.643 * Alb +4.201 * Lg (D-dimer) + 2.938 * Lg (CEA) + 5.441 * Lg (CA 125) + 1.802 * Lg (CA 19-9). The agreement between predicted and surgical PCI was assessed using Bland–Altman plots, showing a limit of agreement (LoA) between −15.847 (95%CI: −17.2646 to −14.4292) and +15.847 (95%CI: 14.4292–17.2646).ConclusionThis study represents the first attempt to use an MLR model for the preoperative prediction of PCI in PMP patients. Nevertheless, the MLR model did not perform well enough in predicting preoperative PCI. In the future, more advanced statistical techniques and a radiomics-based CT-PCI-participated MLR model will be developed, which may enhance the predictive ability of PCI.
Dynamic changes and prognostic value of glutathione S-transferase alpha in mild cognitive impairment and Alzheimer’s disease
Authors: Tang Yangyang , Li Ni , Dai Linyan , Wang Xingsheng , Lai Xia 
Published: December 2024

ObjectivesGlutathione S-transferase alpha (GSTα) is an important antioxidant enzyme closely associated with the onset and progression of neurodegenerative diseases. The alterations in GSTα protein levels associated with Alzheimer’s disease and their impact on cognitive abilities remain unclear. Thus, investigating the fluctuations of GSTα protein levels in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is essential.MethodsDATA were enrolled from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database, and we studied healthy individuals (as controls, a total of 54), patients with mild cognitive impairment (345), and patients with Alzheimer’s disease (96) A one-year follow-up was conducted to collect data on the dynamic changes of GSTα protein levels in plasma and primary information data, and to analyze the correlation between the changes in GSTα protein levels before and after the follow-up and cognitive function and its predictive value.ResultsPlasma GSTα protein levels were significantly lower in the AD group than in the CN group (0.94 vs1.05, p = 0.04) and the MCI group (0.94 vs1.09, p &lt; 0.001). Plasma GSTα protein level changes were positively correlated with altered MMSE levels in MCI and AD patients (r = 0.09, p = 0.04). The AUC (95% CI) of the area under the prediction curve of plasma GSTα protein levels for MCI was 0.63 (0.54–0.71), p = 0.02, and the AUC (95% CI) of the area under the prediction curve of plasma GSTα protein levels for AD was 0.74 (0.69–0.80), p &lt; 0.001. At the same time, we plotted ROC curves for the difference in the change of plasma GSTα protein levels after 1 year of follow-up. The results showed that the AUC (95% CI) of the area under the prediction curve of plasma GSTα protein levels change for MCI was 0.76 (0.696–0.83), p &lt; 0.001, and the AUC (95% CI) of the area under the prediction curve of plasma GSTα protein levels change for AD was 0.75 (0.69–0.80), p &lt; 0.001.ConclusionThe findings of the study indicated notable differences in GSTα protein levels among patients with MCI and those with AD after a one-year follow-up period. Furthermore, a positive correlation was observed between changes in GST αprotein levels and the decline in both baseline and cognitive function. This suggests that GSTα protein could potentially act as a biomarker for both MCI and AD, offering fresh insights for early detection and intervention strategies.
Synthesis and characterization of a fluorescent magnetic molecularly imprinted polymer for enhanced adsorption and selective extraction of pesticides from agricultural waters
Authors: Ali Zeeshan , Raza Nadeem , Hayat Muhammad , Khezami Lotfi , Khairy Mohamed , Almuqri Eman Abdullah , Basher Nosiba S. , Parveen Humaira , Chaudhary Anis Ahmad 
Published: December 2024

IntroductionA novel fluorescent magnetic molecularly imprinted polymer (FMMIP) was developed for the effective extraction of malathion (MLT) and chlorpyrifos (CPS) from agricultural water sources.MethodsThe FMMIP was confirmed to have a stable polymer structure with significant thermal resilience through comprehensive characterization using techniques such as TEM and TGA. The magnetic properties of the FMMIP facilitated easy separation by external magnetic fields, with a notable magnetization of 0.006 emu/g. Kinetic and isotherm studies revealed that adsorption of MLT and CPS onto the FMMIP conformed best to the pseudo-first-order model and Freundlich isotherm, suggesting a predominance of physisorption mechanisms and heterogeneous binding sites.Results and DiscussionThe FMMIP demonstrated exceptional adsorption capacities, achieving a maximum of 93 mg/g for MLT and 69 mg/g for CPS. Regeneration trials indicated that the FMMIP maintains its high adsorptive performance over multiple cycles, highlighting its potential for sustainable use. Statistical validation confirmed the method’s reliability, with RSD values for MLT and CPS at 6.5% and 7.3%, respectively, and LODs determined to be 1.26 mg/L for MLT and 1.22 mg/L for CPS. The strong R2 values of 0.992 for MLT and 0.998 for CPS from the adsorption studies substantiate the method’s effectiveness. This study demonstrates that the synthesized FMMIP is a promising material for removing MLT and CPS, supporting its application in environmental clean-up initiatives to protect and preserve ecosystems.
Prognostic significance of preoperative prognostic nutritional index in hepatocellular carcinoma after curative hepatectomy: a meta-analysis and systemic review
Authors: Zhang Haiyan , Li Dan , Li Jing 
Published: December 2024

BackgroundThe Prognostic Nutritional Index (PNI), which reflects both nutritional and immune status, has emerged as a potential predictor of survival outcomes in cancer patients. However, its role in forecasting the prognosis of hepatocellular carcinoma (HCC) following curative hepatectomy remains unclear. To further investigate the association between PNI and survival outcomes in HCC patients, we conducted a systematic review and meta-analysis.MethodsWe performed a comprehensive search across Web of Science, PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure to identify studies evaluating the prognostic value of PNI in HCC following curative hepatectomy. Overall survival (OS), recurrence-free survival (RFS), and disease-free survival (DFS) were extracted as primary outcomes. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using fixed-effect or random-effect models. Additionally, heterogeneity, publication bias, and sensitivity analyses were performed to evaluate the consistency and robustness of the obtained results.ResultsThis systematic review and meta-analysis included 19 studies comprising a total of 9,830 patients. The results indicated that higher PNI was significantly associated with longer overall survival (OS) (n = 6,812; HR = 1.60; 95% CI: 1.44–1.77; p &lt; 0.001) and recurrence-free survival (RFS) (n = 8,529; HR = 1.48; 95% CI: 1.30–1.69; p &lt; 0.001). There was significant heterogeneity among studies for RFS (I2 = 56.0%, p = 0.004). Subgroup analysis indicated that age, variations in PNI cutoff values and follow-up periods were the primary contributors to this heterogeneity. The trim-and-fill method indicated that publication bias did not impact the OS results, and Egger’s test found no publication bias for RFS (p = 0.104). Sensitivity analysis further confirmed the stability of these results.ConclusionPreoperative PNI is a significant prognostic indicator in HCC patients undergoing curative hepatectomy, with higher PNI correlating with improved survival outcomes.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024530150, identifier CRD42024530150.