bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of a Score for the Detection of Subjects with High Risk for Severe High-Altitude Illness
Authors: RICHALET JEAN-PAUL , PILLARD FABIEN , LE MOAL DAVID , RIVIÈRE DANIEL , ORIOL PHILIPPE , POUSSEL MATHIAS , CHENUEL BRUNO , DOUTRELEAU STÉPHANE , VERGÈS SAMUEL , DEMANEZ SOPHIE , VERGNION MICHEL , BOULET JEAN-MICHEL , DOUARD HERVÉ , DUPRÉ MARYSE , MESLAND OLIVIER , REMETTER ROMAIN , LONSDORFER-WOLF EVELYNE , FREY ALAIN , VILCOQ LOUIS , NEDELEC JAFFUEL ANNE , DEBEAUMONT DAVID , DUPERREX GUY , LECOQ FRANÇOIS , HÉDON CHRISTOPHE , HAYOT MAURICE , GIARDINI GUIDO , LHUISSIER FRANÇOIS J. 
Published: January 2021

ABSTRACT

Purpose
A decision tree based on a clinicophysiological score (severe high-altitude illness (SHAI) score) has been developed to detect subjects susceptible to SHAI. We aimed to validate this decision tree, to rationalize the prescription of acetazolamide (ACZ), and to specify the rule for a progressive acclimatization.

Methods
Data were obtained from 641 subjects in 15 European medical centers before and during a sojourn at high altitude. Depending on the value of the SHAI score, advice was given and ACZ was eventually prescribed. The outcome was the occurrence of SHAI at high altitude as a function of the SHAI score, ACZ prescription, and use and fulfillment of the acclimatization rule.

Results
The occurrence of SHAI was 22.6%, similar to what was observed 18 yr before (23.7%), whereas life-threatening forms of SHAI (high-altitude pulmonary and cerebral edema) were less frequent (2.6%–0.8%, P = 0.007). The negative predictive value of the decision tree based was 81%, suggesting that the procedure is efficient to detect subjects who will not suffer from SHAI, therefore limiting the use of ACZ. The maximal daily altitude gain that limits the occurrence of SHAI was established at 400 m. The occurrence of SHAI was reduced from 27% to 12% when the recommendations for ACZ use and 400-m daily altitude gain were respected (P < 0.001).

Conclusions
This multicenter study confirmed the interest of the SHAI score in predicting the individual risk for SHAI. The conditions for an optimized acclimatization (400-m rule) were also specified, and we proposed a rational decision tree for the prescription of ACZ, adapted to each individual tolerance to hypoxia.
Spontaneous Eye Blink Rate Connects Missing Link between Aerobic Fitness and Cognition
Authors: KUWAMIZU RYUTA , SUWABE KAZUYA , DAMRONGTHAI CHORPHAKA , FUKUIE TAKEMUNE , OCHI GENTA , HYODO KAZUKI , HIRAGA TAICHI , NAGANO-SAITO ATSUKO , SOYA HIDEAKI 
Published: January 2021

ABSTRACT

Purpose
Higher aerobic fitness, a physiological marker of habitual physical activity, is likely to predict higher executive function based on the prefrontal cortex (PFC), according to current cross-sectional studies. The exact biological link between the brain and the brawn remains unclear, but the brain dopaminergic system, which acts as a driving force for physical activity and exercise, can be hypothesized to connect the missing link above. Recently, spontaneous eye blink rate (sEBR) was proposed and has been used as a potential, noninvasive marker of brain dopaminergic activity in the neuroscience field. To address the hypothesis above, we sought to determine whether sEBR is a mediator of the association between executive function and aerobic fitness.

Methods
Thirty-five healthy young males (18–24 yr old) had their sEBR measured while staring at a fixation cross while at rest. They underwent an aerobic fitness assessment using a graded exercise test to exhaustion and performed a color–word Stroop task as an index of executive function. Stroop task–related cortical activation in the left dorsolateral PFC (l-DLPFC) was monitored using functional near-infrared spectroscopy.

Results
Correlation analyses revealed significant correlations among higher aerobic fitness, less Stroop interference, and higher sEBR. Moreover, mediation analyses showed that sEBR significantly mediated the association between aerobic fitness and Stroop interference. In addition, higher sEBR was correlated with higher neural efficiency of the l-DLPFC (i.e., executive function was high, and the corresponding l-DLPFC activation was relatively low).

Conclusion
These results indicate that the sEBR mediates the association between aerobic fitness and executive function through prefrontal neural efficiency, which clearly supports the hypothesis that brain dopaminergic function works to connect, at least in part, the missing link between aerobic fitness and executive function.
HFE Genotype and Endurance Performance in Competitive Male Athletes
Authors: THAKKAR DRISHTI , SICOVA MARC , GUEST NANCI S. , GARCIA-BAILO BIBIANA , EL-SOHEMY AHMED 
Published: January 2021

ABSTRACT

Introduction
Hereditary hemochromatosis can cause individuals to absorb too much iron from their diet. Higher tissue iron content, below the threshold of toxicity, may enhance oxygen carrying capacity and offer a competitive advantage. Single nucleotide polymorphisms (SNP) in the homeostatic iron regulator (HFE) gene have been shown to modify iron metabolism and can be used to predict an individual’s risk of hemochromatosis. Several studies have shown that HFE genotypes are associated with elite endurance athlete status; however, no studies have examined whether HFE genotypes are associated with endurance performance.

Purpose
The objectives of this study were to determine whether there was an association between HFE risk genotypes (rs1800562 and rs1799945) and endurance performance in a 10-km cycling time trial as well as maximal oxygen uptake (V˙O2peak), an indicator of aerobic capacity.

Methods
Competitive male athletes (n = 100; age = 25 ± 4 yr) completed a 10-km cycling time trial. DNA was isolated from saliva and genotyped for the rs1800562 (C282Y) and rs1799945 (H63D) SNP in HFE. Athletes were classified as low risk (n = 88) or medium/high risk (n = 11) based on their HFE genotype for both SNP using an algorithm. ANCOVA was conducted to compare outcome variables between both groups.

Results
Individuals with the medium- or high-risk genotype were ~8% (1.3 min) faster than those with the low-risk genotype (17.0 ± 0.8 vs 18.3 ± 0.3 min, P = 0.05). V˙O2peak was ~17% (7.9 mL·kg−1⋅min−1) higher in individuals with the medium- or high-risk genotype compared with those with the low-risk genotype (54.6 ± 3.2 vs 46.7 ± 1.0 mL·kg−1⋅min−1, P = 0.003).

Conclusion
Our findings show that HFE risk genotypes are associated with improved endurance performance and increased V˙O2peak in male athletes.
Hemodialysis as long term treatment: Patients satisfaction and its impact on quality of life
Authors: Iqbal Muhammad Sajid , Iqbal Quratulain , Iqbal Shahreen , Ashraf Sania 
Published: January 2021

Objective: To determine the level of satisfaction as hemodialysis a long term treatment and quality of life in patients off End Stage Kidney Disease ESKD on hemodialysis.
Methods: A cross-sectional study was carried out from January to April 2019 in hemodialysis unit of Lahore General Hospital on 141 ESKD patients by using self-designed questionnaire after informed consent.
Results: Majority (82.56%) of the participants were satisfied with the care provided at the dialysis center. except with the time spent with doctor and 36.9% were not satisfied with their cannulation technique for dialysis. About 89.9% were satisfied with the knowledge provided to them about self-care. Satisfaction is subjective well-being in different aspects of life, including mental health and behavior of people experiencing serious health concerns. Quality of Life (QOL) is defined as “perception of one’s position in life, in the light of his culture and customs, consisting someone’s goals, standards or expectations. Financial problems to the patient was limited to the transportation as dialysis session and erythropoietin were free, but 54.1% of the patients were unable to earn due to their disease even those who were working ,80% of them had to take the day off for dialysis. The financial burden and debilitating illness didn’t cause separation/divorce from spouse but led to increased frequency of scuffles. Among the unmarried population, 40% of it does not want to start a relationship and 40% is facing difficulties in finding a partners while 97.9% of the population is satisfied with the psychological and emotional support of family.
Conclusion: Most patients were satisfied with their decision of opting hemodialysis as treatment and care provided at dialysis centre, although Quality of Life was badly affected in terms of financial and psycho-social aspects. Employed, married with good income have good quality of life. Loopholes of unit environment and health education were also exposed. Despite the medical advancement and emerging techniques to make dialysis better, the outcome of hemodialysis has yet to reach a safe level and more work should be done to improve patient’s outcome.
doi: https://doi.org/10.12669/pjms.37.2.2747
How to cite this:Iqbal MS, Iqbal Q, Iqbal S, Ashraf S. Hemodialysis as long term treatment: Patients satisfaction and its impact on quality of life. Pak J Med Sci. 2021;37(2):398-402. doi: https://doi.org/10.12669/pjms.37.2.2747
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The clinical impact of hydroresponsive dressings in dynamic wound healing: Part I
Authors: Sterpione Francois , Mas Karine , Rippon Mark , Rogers Alan , Mayeux Georges , Rigaudier Florian , Chauvelot Pierre , Robilliart Ludovic , Juhel Christine , Lecomte Yann 
Published: January 2021

Objective: Management of any wound, either acute or hard-to-heal, might involve the use of multiple and different wound dressings in its treatment. This approach is necessary to overcome the myriad of clinical challenges the wound presents, as well as any underlying comorbidities that might affect the clinical outcomes. This article describes the clinical effectiveness of a coordinated wound dressing treatment regimen. Method: This was an open-labelled non-comparative study involving patients with a variety of hard-to-heal and acute wounds of differing levels of severity, but all of which required removal of devitalised tissue to enable wound healing to progress. The first phase used the hydroresponsive wound dressing HydroClean (PAUL HARTMANN AG, Germany). The PUSH score was used as the primary measurement parameter. Results: A total of 86 patients (38 male/48 female), with a mean age of 67.7±21.7 years, took part in the study. The results showed that the hydroresponsive dressing was effective in managing wound exudate production and promoting wound cleansing and debridement, supporting good wound bed preparation. Wound closure was observed in 16/86 (18.6%) wounds at the end of the study (20 weeks). This enabled clinicians to switch to alternative wound dressings to promote subsequent clinical healing outcomes. Conclusion: In this study, the hydroresponsive wound dressing was highly effective in preparing a clean wound bed such that the next stage of wound healing could be supported.
Development of Indonesian Language Text Books with Multiculturalism and Character Education to Improve Traditional Poetry Writing Skills
Authors: Winarni Retno , Slamet St Y , Syawaludin Ahmad 
Published: January 2021

<p style="text-align:justify">This research aims to develop Indonesian Language textbooks with multiculturalism and character education for traditional poetry writing learning. This research uses a research and development approach until the discovery of a proper textbook. The subjects involved in this study were 101 elementary school fourth-graders, 33 teachers, and 2 Indonesian language and literature learning experts. Data analysis techniques at the need analysis stage through interactive models, and data analysis at the product testing stage using quantitative techniques with non-independent t-test statistics. Preliminary studies found that teachers and students needed creative writing skills textbooks developed by integrating the values of multiculturalism and character education. Textbook development referred to aspects of content, language, presentation, and graphics. Limited textbook product testing using t-test showed that t-obtained= -4,265 and t-table on α = 5 % is 2,064, so H0 is rejected. Broad testing also resulted in t-obtained= -6,426 and t-table = 2,004, so it can be decided that H0 is rejected. Students' traditional poetry writing skills after learning using textbooks are better than before learning using textbooks. Thus it is concluded that the textbooks developed are inferred worthy of use by teachers and students to improve their writing skills in elementary school.</p>
Machine-learning-based EDFA gain estimation [Invited]
Authors: Yu Jiakai , Zhu Shengxiang , Gutterman Craig L. , Zussman Gil , Kilper Daniel C. 
Published: January 2021

Optical transmission systems with high spectral efficiency require accurate quality of transmission estimation for optical channel provisioning. However, the wavelength-dependent gain effects of erbium-doped fiber amplifiers (EDFAs) complicate precise optical channel power prediction and low-margin operation. In this work, we examine supervised machine learning methods using multiple artificial neural networks (ANNs) to build models for gain spectra prediction of optical transmission line EDFAs under different operating conditions. Channel-loading configurations and channel input power spectra are used as an a posteriori knowledge data feature for model training. In a hybrid learning approach, estimated gain spectra calculated by an analytical model are added as an a priori input data feature to further improve the EDFA ANN model performance in terms of prediction accuracy, training time, and quantity of training data. Using these methods, the root mean square error and maximum absolute error of the predicted channel output power can be as low as 0.144 dB and 1.6 dB, respectively.
Giant enhancements of high-order upconversion luminescence enabled by multiresonant hyperbolic metamaterials
Authors: Xu Haofei , Zhu Zhimin , Xue Jiancai , Zhan Qiuqiang , Zhou Zhangkai , Wang Xuehua 
Published: January 2021

Photonic nanostructures with resonant modes that can generate large electric field (EF) enhancements are applied to enhance light-matter interactions in nanoscale, bringing about great advances in both fundamental and applied science. However, a small hot spot (i.e., the regions with strong EF enhancements) and highly inhomogeneous EF distribution of the resonant modes usually hinder the enhancements of light-matter interactions in a large spatial scale. Additionally, it is a severe challenge to simultaneously generate multiple resonant modes with strong EF enhancements in a broadband spectral range, which greatly limits the capacity of a photonic nanostructure in boosting optical responses including nonlinear conversion, photoluminescence, etc. In order to overcome these challenges, we presented an arrayed hyperbolic metamaterial (AHMM). This AHMM structure is applied to simultaneously enhance the three-photon and four-photon luminescence of upconversion nanoparticles. Excitingly, the enhancement of the three-photon process is 1 order of magnitude larger than previous records, and for the enhancing four-photon process, we achieve an enhancement of 3350 times, greatly beneficial for overcoming the crucial problem of low efficiency in near infrared light upconversion. Our results demonstrated a promising platform for realizing giant enhancements of light-matter interactions, holding potential in constructing various photonics applications such as the nonlinear light sources.
Impact of COVID-19 on hospital admission of acute stroke patients in Bangladesh
Authors: Hasan A. T. M. Hasibul , Das Subir Chandra , Islam Muhammad Sougatul , Mansur Mohaimen , Shawon Md. Shajedur Rahman , Hassan Rashedul , Chowdhury Mohammad Shah Jahirul Hoque , Mondal Md. Badrul Alam , Mohammad Quazi Deen 
Published: January 2021

Background
With the proposed pathophysiologic mechanism of neurologic injury by SARS CoV-2, the frequency of stroke and henceforth the related hospital admissions were expected to rise. This paper investigated this presumption by comparing the frequency of admissions of stroke cases in Bangladesh before and during the pandemic.

Methods
This is a retrospective analysis of stroke admissions in a 100-bed stroke unit at the National Institute of Neurosciences and Hospital (NINS&H) which is considerably a large stroke unit. All the admitted cases from 1 January to 30 June 2020 were considered. Poisson regression models were used to determine whether statistically significant changes in admission rates can be found before and after 25 March since when there is a surge in COVID-19 infections.

Results
A total of 1394 stroke patients took admission in the stroke unit during the study period. Half of the patients were older than 60 years, whereas only 2.6% were 30 years old or younger. The male to female ratio is 1.06:1. From January to March 2020, the mean rate of admission was 302.3 cases per month, which dropped to 162.3 cases per month from April to June, with an overall reduction of 46.3% in acute stroke admission per month. In those two periods, reductions in average admission per month for ischemic stroke (IST), intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH) and venous stroke (VS) were 45.5%, 37.2%, 71.4% and 39.0%, respectively. Based on weekly data, results of Poisson regressions confirm that the average number of admissions per week dropped significantly during the last three months of the sample period. Further, in the first three months, a total of 22 cases of hyperacute stroke management were done, whereas, in the last three months, there was an 86.4% reduction in the number of hyperacute stroke patients getting reperfusion treatment. Only 38 patients (2.7%) were later found to be RT-PCR SARS Cov-2 positive based on nasal swab testing.

Conclusion
This study revealed a more than fifty percent reduction in acute stroke admission during the COVID-19 pandemic. Whether the reduction is related to the fear of getting infected by COVID-19 from hospitalization or the overall restriction on public movement or stay-home measures remains unknown.
Association between dietary diversity with overweight and obesity: A cross-sectional study conducted among pastoralists in Monduli District in Tanzania
Authors: Khamis Ahmed Gharib , Ntwenya Julius Edward , Senkoro Mbazi , Mfinanga Sayoki Godfrey , Kreppel Katharina , Mwanri Akwilina Wendelin , Bonfoh Bassirou , Kwesigabo Gideon 
Published: January 2021

Background
The prevalence of overweight and obesity is rising at a rapid pace and is associated with negative health consequences like cardiovascular diseases, type 2 diabetes and cancer. Obesity is a multifactorial problem that develops mainly from lifestyle factors including physical inactivity and poor dietary intake. Dietary diversity is a simplified method for assessing the adequacy and quality of diet and is associated with nutritional need and overall health status. Therefore, we conducted this study to synthesize the associations between consumption of a diversified diet and overweight/ obesity among adults living in pastoral communities in Monduli district in Tanzania.

Methods
This was a cross-sectional study conducted among 510 adults aged ≥ 18 years old in the Monduli district, Arusha region in Tanzania. We conducted face-to-face interviews to collect information about socio-demographic characteristics, 24-hours dietary recall, and anthropometric measurements. The dietary diversity score (DDS) was constructed and used to determine the diversity of the diet consumed. We performed the multivariate Poisson regressions to determine the prevalence ratio (PR) with 95% confidence intervals (CI). The dependent variables were overweight and general obesity as measured by body mass index (BMI), abdominal obesity measured by waist-hip ratio (WHR) and waist circumference (WC).

Results
The prevalence of general obesity based on BMI was 20.2% (95%CI; 16.9–23.9), abdominal obesity based on WHR was 37.8% (95%CI; 33.7–42.1), and WC was 29.1% (95%CI; 25.2–33.1). More than half (54.3%) of the participants consumed an adequate dietary diversity (DDS ≥4). After adjustment for potential confounders, the prevalence of abdominal obesity by WHR decreased with higher DDS among male (APR = 0.42; 95% CI, 0.22–0.77) and female participants (APR = 0.63; 95% CI, 0.41–0.94). There were inconsistent positive associations between DDS and prevalence of overweight and general obesity among male and female. There was no association between DDS and abdominal obesity by WC.

Conclusion
More than half of the pastoralists have consumed an adequate diversified diet. Given the inconsistent findings on associations between dietary diversity and obesity measures, this study suggests that targeting dietary diversity as an overweight/obesity prevention strategy requires careful consideration.
Policymaking through a knowledge lens: Using the embodied-enacted-inscribed knowledge framework to illuminate the transfer of knowledge in a mental health policy consultation process – A South African case study
Authors: Marais Debra Leigh , Petersen Inge , Quayle Michael 
Published: January 2021

Background
Marrying principles of evidence-based policymaking, with its focus on what works, with principles of consultative policymaking, with its focus on what works for whom, means finding ways to integrate multiple knowledge inputs into policy decisions. Viewed through the lens of the embodied-enacted-inscribed knowledge framework, policy consultation is a site of knowledge enactment, where the embodied knowledge enacted by individuals engages with the inscribed knowledge contained in policy documents, creating new forms of embodied and inscribed knowledge that move beyond these spaces.

Aim
Using this knowledge framework, this study aimed to trace the movement of knowledge inputs through South Africa’s mental health policy consultation summit.

Methods
Breakaway group session transcripts from the national consultation summit were thematically analysed to identify the types of knowledge that participants explicitly drew on (experiential or evidence-based) during discussions and how these knowledge inputs were used, responded to, and captured.

Findings
Findings suggest that there was little explicit reference to either evidence-based or experiential knowledge in most of the talk. While slightly more evidence-based than experiential knowledge claims were made, this did not render these claims any more likely to be responded to or engaged with in group discussions, or to be inscribed in group recommendations.

Discussion
The importance of designing participatory processes that enable optimal use of knowledge inputs in these enacted spaces is discussed.

Conclusion
Attending to the specific ways in which knowledge is transformed and moved through a policy consultation process has the potential to enhance the value that consultation offers policymakers.