bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wabishki Bizhiko Skaanj: a learning pathway to foster better Indigenous cultural competence in Canadian health research
Authors: Robinson-Settee Helen , Settee Craig , King Malcolm , Beaucage Mary , Smith Mary , Desjarlais Arlene , Chiu Helen Hoi-Lun , Turner Catherine , Kappel Joanne , McGavock Jonathon M. 
Published: May 2021

Abstract
Objective
In Canada, Indigenous people experience racism across diverse settings, including within the health sector. This has negatively impacted both the quality of care that Indigenous people receive as well as how research related to Indigenous populations is conducted. Therefore, an Indigenous-led council at a kidney research network, in partnership with other key stakeholders, sought to create a learning pathway that aims to distill the racism that Indigenous people face, and build cultural competence, within the health sector.

Participants
The learning pathway was designed for researchers, health care providers, patient partners and administrators.

Setting
Various components of the pathway are established trainings in healthcare and research settings at provincial and national levels. Provincially, some components are implemented in British Columbia, Alberta, Saskatchewan, Manitoba and Ontario.

Intervention
The pathway, called Wabishki Bizhiko Skaanj (meaning “White Horse” in Anishinaabemowin), involves six key steps: a culturally tailored blanket exercise that walks participants through the history of local Indigenous Nations/peoples; a more detailed online training program (San’yas); a series of webinars on Indigenous research ethics and protocols; an educational booklet about engaging Knowledge Keepers in research, as well as sharing details about their traditional knowledge and culture; two certification programs about Indigenous ownership of data; and a “book club,” wherein the conversation of racism—and the goal for finding solutions—is continually discussed.

Outcomes
Wabishki Bizhiko Skaanj is working to build cultural competence in the Canadian health sector.

Implications
This learning pathway has the potential to address racial disparities across the country and improve health outcomes for Indigenous peoples.
Sh-Sy5y hücre hattında sodyum bütiratın bazı alternatif kırpılma genleri ve BACE1 izoformları üzeindeki etkisi
Authors: AKSOY Gülsevinç , LÜLEYAP Ümit , EVYAPAN Gülşah , PAZARCI Perçin , ALPTEKİN Davut , PAZARBAŞI Ayfer , YILMAZ Mehmet Bertan 
Published: May 2021

Amaç: Bu çalışmanın amacı, bir Histon Deasetilaz (HDAC) inhibitörü olan Sodyum Bütirat’ın(NaB) BACE1/501, BACE1/457 ve BACE1/432 gibi BACE1 izoformları ve hnRNP H, U2AF35, U2AF65, SRSF1, SRSF2, SRSF5 ve SRSF6 alternatif kırpılma faktörleri üzerindeki etkisini araştırmaktır.
Gereç ve Yöntem: Bu çalışmada, SH-SY5Y hücreleri 1 mM ve 5 mM Na Bile muamele edilmiştir. Daha sonra BACE1 izoformları ve alternative kırpılma genlerinin ekspresyonlarındaki değişimleri değerlendirmek için Real-Time PCR yöntemi kullanılmıştır.
Bulgular: 5 mM NaB konsantrasyonunda SRSF6, SRSF1, SRSF2, SRSF5 ve U2AF65 genlerinin ekspresyonlarında %35’ten %80’e kadar görece bir azalma olduğu belirlenmiştir. Ayrıca 5 Mm NaB BACE1/501, BACE1/457 ve BACE1/432 izoformlarının ekspresyonunu artırmıştır. NaB konsantrasyonu arttıkça, SRSF5 geninin ekspresyonu diğerlerinden daha fazla azalmıştır.
Sonuç: Bulgularımızdan yola çıkılarak, U2AF65 ve SRSF6 genlerinin BACE1/457 ve BACE1/432 izoformlarının artışına diğer genlerden daha fazla katkı sağladığı sonucuna varılmıştır.
Validity and reliability of Turkish version of the Recent Physical Activity Questionnaire
Authors: DEMİRCİOĞLU Arzu , DAĞ Osman , ÖZKAL Özden 
Published: May 2021

Purpose:  Physical inactivity is an important determinant of chronic disease such as obesity, cardiovascular disease and certain types of cancer. Therefore, evaluation of physical activity becomes more important day by day. The purpose of the present study was to investigate the validity, reliability and Turkish version of The Recent Physical Activity Questionnaire (RPAQ) in healthy population.
Materials and Methods: A total of 192 adults were included in the study. Standard "forward-backward" procedure used in translation of RPAQ. International Physical Activity Questionnaire-Long Form (IPAQ-LF) was used as the gold standard for the validity of RPAQ. It was re-adminestered on 50 participants one week interval for reliability of RPAQ analysis.
Results: 122 (63.5%) were women, 70 (36.5%) were men of participants, and their mean age was 34.469.45 years. There was a high correlation between total score of IPAQ-LF and RPAQ (r: 0.747, p
Influence of Kinako Manufacturing Process on the Isoflavone Profile
Authors: Silva Letícia Cardoso , Benedetti Silvia , Bonifácio da Silva Josemeyre 
Published: May 2021

As formas agliconas das isoflavonas de soja são os principais compostos bioativos associados à promoção da saúde. Durante o processamento térmico para produção de alimentos de soja ocorrem alterações no nível e no perfil das isoflavonas, porém, a estabilidade térmica e a interconversão desses compostos não foram totalmente esclarecidas. O objetivo deste estudo foi investigar os efeitos de diferentes tempos e temperaturas durante o preparo da farinha integral de soja torrada (kinako) na interconversão das formas de glicosídicas das isoflavonas em agliconas. Os grãos da cultivar de soja BRS 267 foram submetidos a diferentes tempos (10, 15 e 20 min) e temperaturas (180, 210 e 240 °C) seguindo um Delineamento Composto Central (DCC) 22. Em seguida, os grãos foram moídos e desengordurados para à extração e quantificação das diferentes formas de isoflavonas por Cromatografia Líquida de Ultra Alta Eficiência (CLUAE). O efeito do tempo e da temperatura durante a obtenção do kinako sobre o teor de β-glicosídeos e malonilglicosídeos foi negativo e linear e sobre os níveis de agliconas foi significativamente negativo e quadrático. A farinha de soja integral torrada ou kinako preparada a 210 °C por 15 min tem um maior teor de genisteína.

Palavras chaves: Farinha de Soja Torrada. Tratamento Térmico. Genisteína.

Abstract
The soy aglycone isoflavone forms are major bioactive compounds associated with the promotion health. During thermal processing for production of soyfoods occur change the level and profile of isoflavones, but thermal stability and interconversion of these compounds have not been fully clarified. The aim of this study was to investigate the different times and temperatures effects during the preparation of whole roasted soybean flour (kinako) on the interconversion of glucoside isoflavones forms into aglycones. The grains of the soybean cultivar BRS 267 were subjected to different times (10, 15 and 20 min) and temperatures (180, 210 and 240 °C) following a Central Composite Design (DCC) 22. After, the grains were ground and defatted to extraction and quantification of the different forms of isoflavones by ultra high performance liquid chromatography (UHPLC). The effect of time and temperature during obtained of the kinako on the β-glucosides and malonylglucosides content was significant negative and linear and on the aglycones levels was significant negative and quadratic. Whole roasted soybean flour or kinako prepare at 210 °C for 15 min has a the higher genistein content.

Keywords: Roasted Soybean Flour. Thermal Treatment. Genistein.
Qualidade de Água do Rio Cuiabá no Perímetro Urbano da Capital Mato-Grossense
Authors: Arruda Jorge Luiz de , Marques Ana Carolina Amorim , Borges Pinto Junior Osvaldo 
Published: May 2021

Este trabalho apresenta uma análise do índice e dos parâmetros de qualidade de água no perímetro urbano do rio Cuiabá - MT, considerando uma variação temporal (período úmido e seco) e espacial (montante - jusante) no ano de 2015. Os resultados mostraram que maiores valores de turbidez, sólidos totais, oxigênio dissolvido, demanda bioquímica de oxigênio e coliformes totais foram obtidos no período úmido e que os maiores valores de pH, nitrogênio/nitrato e fósforo/fosfato ocorreram no período seco. O Índice de Qualidade de Água (IQA) foi maior no período seco em função de menores valores sólidos em suspensão, turbidez e coliformes totais. A análise da água da região perimetral ao rio Cuiabá demonstrou diferenças significativas entre os pontos mais a montante (Sucuri) em relação aos pontos a jusante (Porto e Caís) em ambos os períodos. Nesse sentido, o IQA foi menor nos pontos mais a jusante (Porto, Caís e Comunidade São Gonçalo Beira Rio) que nos pontos mais a montante (Sucuri e Ribeirão do Lipa). Os parâmetros estudados atendem a normatização da Resolução Conama 357/2005, apesar das diferenças no IQA para os pontos amostrados entre os períodos sazonais.

Palavras-chave: Efluente. Índice de Qualidade. Valoração Ambiental.

Abstract
This work presents an analysis of the index and water quality parameters in the urban perimeter of Cuiabá - MT, considering a temporal (rainy and dry period) and spatial (downstream) variation in the year 2015. Higher turbidity values, total dissolved oxygen, biochemical oxygen demand and total coliforms were obtained in the rainy season, while higher values ​​of pH, nitrogen / nitrate and phosphorus / phosphate occurred in the dry period. IQA was higher in the dry period due to lower suspended solids, turbidity and total coliforms. The water analysis from the perimeter region to the Cuiabá river showed significant differences between the points upstream (Sucuri) in relation to the downstream points (Porto and Caís) in both periods. In this sense, the IQA was smaller in the points downstream (Porto, Caís and Comunidade São Gonçalo Beira Rio) than in the most upstream points (Sucuri and Ribeirao do Lipa). The studied parameters comply with the normalization of Conama Resolution 357/2005, despite the differences in the IQA for the points sampled between the seasonal periods.

Keywords: Effluent. Quality Index. Environmental Valuation.
Protetor Esportivo para Pacientes Ortodônticos: Importância e Técnica de Manufatura
Authors: Scarsi Luciana Sayuri Shida , Gialain Ivan Onone 
Published: May 2021

O trauma orofacial esportivo em pacientes ortodônticos fixos poderá implicar em lesões com diferentes graus de severidade, reversíveis e irreversíveis, podendo acometer tanto tecidos bucais moles quanto duros. As lesões, normalmente, ocorrem pelo contato destes tecidos com o agente traumatizante e pelo próprio contato do aparelho com os tecidos intrabucais. Portanto, em pacientes sob tratamento ortodôntico com aparelho fixo, a recomendação do uso do protetor bucal deve ser enfatizada, pois, em casos extremos, pode ocorrer também a perda parcial ou total de elementos dentais. O protetor bucal pode ser definido como um dispositivo recomendado para a proteção das estruturas orais de pacientes durante a prática de atividade esportiva. Dependendo da atividade esportiva, como nos esportes de contato, há obrigatoriedade estabelecida por federações e confederações para o seu uso como equipamento de proteção individual. O presente trabalho apresenta o passo a passo de uma técnica simples e de baixo custo para a confecção de um protetor bucal personalizado, através da modificação da técnica convencional, promovendo um alívio durante a moldagem, o que permite o uso confortável e seguro em pacientes ortodônticos. Além disso, o presente artigo reforça a importância do dentista em prescrever e conscientizar, tanto o atleta profissional quanto o amador, no uso deste dispositivo preventivo, que pode ser confeccionado em uma sessão, evitando possíveis prejuízos bucais e resguardando o paciente de danos físicos, psicológicos, sociais e financeiros.

Palavras-chave: Protetor Bucal. Esporte. Ortodontia.

Abstract
Sports orofacial trauma in fixed orthodontic patients may result in different degrees of severity, reversible and irreversible injuries, in soft and hard oral tissues, by their contact with the traumatizing agent and by the device contact with intraoral tissues. Therefore, in these conditions, the recommendation for the use of mouthguards should be emphasized because, in extreme cases, partial or total loss of dental elements may also occur. The mouthguard can be described as a device with the purpose to avoid injuries to patients’ oral structures during the practice of sports activity. Depending on the sporting activity, as in contact sports, the use as personal protective equipment is imposed by federations and confederations. The objective of this article is to present the step by step of a simple and low-cost technique for the confection of a personalized mouth guard, through the conventional technique modification, creating a relief during molding, which allows the comfortable and safe use in orthodontic patients. In addition, this article aims to reinforce the dentist’s importance in prescribing and raising awareness, both professional and amateur athletes, in the use of this preventive device that can be made in one session, avoiding possible oral damage and also protecting the patient from psychological, social and financial injuries.

Keywords: Mouthguard. Sport. Orthodontics.
Artrite Reumatoide e a Poluição do Ar
Authors: Dos Santos Souza Magalhães Dayane , Rosa Espírito Santo de Freitas Leticia , Dos Santos Peres Santos Souza Maria Amélia , Fernandes Vander , Shimoya-Bittencourt Walkiria , Almeida Leite da Silva Cristhiane 
Published: May 2021

A artrite reumatoide é uma doença inflamatória, crônica, autoimune, sistêmica e progressiva com etiologia ainda desconhecida, que causa danos progressivos ao sistema musculoesquelético. Esta doença atinge aproximadamente 0,5% a 1% da população mundial, predomina no sexo feminino e acomete todas as faixas etárias com maior prevalência entre 40-60 anos. A atividade da doença é avaliada pelo Índice de Atividade da Doença (DAS28) analisando 28 articulações. Estudos demonstram que a poluição atmosférica está associada aos agravos à saúde humana e à perda de qualidade de vida. Este estudo teve como objetivo relatar o papel da poluição atmosférica na artrite reumatoide, através de uma revisão narrativa de literatura, a partir das bases de dados PubMed e Scielo. Incluíram-se artigos nos idiomas inglês e português publicados em periódicos, nacionais e internacionais, acerca da temática da pesquisa. A relação entre o desenvolvimento da AR e diferentes poluentes atmosféricos foi analisada em diversos estudos, que demostraram associação entre diferentes poluentes atmosféricos e o desenvolvimento da doença, no entanto, nenhum estudo publicado até a data atual, avaliou a relação com a exacerbação da atividade da doença.

Palavras-chave: Artrite Reumatoide. Poluição do Ar. Doenças Autoimunes.

Abstract
Rheumatoid arthritis is an inflammatory, chronic, autoimmune, systemic and progressive disease with a still unknown etiology that causes progressive damage to the musculoskeletal system. This disease affects approximately 0.5% to 1% of the world population, predominates in females and affects all age groups with a higher prevalence between 40-60 years. The disease activity is assessed by the Disease Activity Index (DAS28) analyzing 28 joints. Studies show that air pollution is associated with damage to human health and loss of quality of life. This study aimed to report the role of air pollution in rheumatoid arthritis, through a literature narrative review, using the PubMed and Scielo databases. Articles in English and Portuguese published in national and international journals about the research theme were included. The relationship between the RA development and different air pollutants has been analyzed in several studies, which showed an association between different air pollutants and the development of the disease, however, no study published to date has evaluated the relationship with the disease activity exacerbation.

Keywords: Rheumatoid Arthritis. Air Pollution. Autoimmune Diseases.
Avaliação do Conhecimento e o Uso de Isotretinoína com Alunos de uma Instituição de Ensino Superior do Município de Anápolis-Goiás
Authors: Lemes Erick de Oliveira , Francisco de Andrede Aleixo , Amaral Diniz Erika , De Cubas Vieira Soares Geysse 
Published: May 2021

A isotretinoína pertence a um grupo de medicamentos chamados resinoides, relacionados à vitamina A, é conhecida por Roacutan®, sendo indicada em diversas dermatoses, principalmente na acne nodulocística. A sua ação baseia-se na diminuição do tamanho das glândulas sebáceas, diminuindo a produção de sebo, possibilitando a inibição da formação de comedões que ocorre pela ação do Propionibacterium acnes, responsável pelo processo inflamatório cutâneo e pela estimulação da produção de anticorpos. Este trabalho teve como objetivo avaliar o conhecimento e o uso de isotretinoína com alunos de uma instituição de ensino superior do município de Anápolis-Goiás. Foi desenvolvido uma pesquisa, com alunos de uma instituição de ensino superior do município de Anápolis, Goiás, através de questionário, semiestruturado. Observou-se que 66.67% dos alunos alcançaram o resultado pretendido e 33.33% não obtiveram êxito quanto ao tratamento, mostrando-se insatisfeitos com a Isotretinoína. Vale ressaltar também que todos os pacientes afirmaram estar cientes dos efeitos nocivos da isotretinoína durante o tratamento. Com a realização deste estudo é possível concluir que ambos os sexos procuram o uso da isotretinoína para tratamento. Desta forma, o estudo realizado buscou conhecer mais sobre o perfil dos usuários desse fármaco, juntamente com os efeitos adversos mais apresentados e se houve recidivas da acne após o uso.

Palavras-chave: Retinóides. Roacutan. Pacientes.

Abstract
Isotretinoin belongs to a group of medicamen called resinoids, related to vitamin A, is known as Roacutan®, being indicated in several dermatoses, mainly in doducteistic acne. Its action is based on the decrease in the size of sebaceous glindils, decreasing the production of sebum, allowing the inhibition of the formation of comesn that occurs by the action of Propionibacterium acnes, responsible for the cutaneo inflamasorous process and the desatimization of antibody production. This study aimed to evaluate the knowledge and use of isotretinoin with alums from a higher education institution of the municipality of Anápolis-Goiás. A research was conducted with alums from a higher education institution in the municipality of Anápolis, Goiás, through a semi-structured questionnaire. It was observed that 66.67% of the students achieved the intended result and 33.33% were unsuccessful in treatment, showing to be dissatisfied with Isotretinoin. It is also worth mentioning that all pacients stated that they were aware of the harmful effects of isotretinoin during treatment. With the implementation of this esudo it is possible to agree that both sexes seek the use of isotretinoin for treatment. Thus, the edudo realiso sought to know more about the profile of users of this drug, along with the most presented adverse effects and whether there was a relapse of acne after use.

Keywords: Retinoids. Roacutan. Patients.
Effect of voice fold length on voice range in novice vocalists
Authors:   Irkutsk State Medical University,  Irkutsk, 664003, Russia, Subbotina M. V. , Zabbarova I. B. ,   Irkutsk Regional Clinical Advisory and Diagnostic Center,  Irkutsk, 664047, Russia
Published: May 2021

The aim of the study was to determine the effect of vocal cord length on vocal range in aspiring vocalists. On the basis of the Frederic Chopin Irkutsk Regional College of Music. 141 student vocalists (18 ± 3.6 years, 122 girls) underwent indirect laryngoscopy, the length of the vocal folds was measured using an ultrasound scan of the larynx using an Aloka SSD 500 apparatus with a 5 MHz sensor during breathing and during phonation of the lowest and highest tones, measured weight and height, the voice range in Hz and the number of semitones were assessed. Spearman’s correlation coefficient was calculated, the significance of differences according to the U-Mann – Whitney and Wilcoxon criteria was calculated using the Statistica 10.0 software (reliable data at p <0.05*). Results. Spearman’s correlation coefficient was: between the length of the vocal folds and weight + 0.52*, height + 0.43*, gender + 0.45* (female 1, male 2), the lowest tone –0.34*, between height and the lowest tone is –0.23*. The range of the voice in arbitrary units and Hz correlated weakly with the length of the folds during breathing (-0.18/–0.24*, respectively), with the lowest pitch (+ 0.42/+ 0.59 *), but there was a high correlation with the highest (+ 0.88/+ 0.99*). The latter depended on: the length of the vocal folds at rest (–0.32*), weight (–0.25*), gender (–0.45*), the length of the folds during high-pitched phonation (–0.6*). Differences in the length of the vocal folds during breathing in female vocalists with different vocal ranges were not significant, while in males and females (soprano) they were significant. The length of the fold during phonation in all types of voices was shorter than during breathing. The voice range of novice vocalists was increased mainly by high tones in parallel with the shortening of folds during phonation, which could be measured using ultrasound scanning and which is achieved by training.
PENGEMBANGAN MEDIA PEMBELAJARAN KOKAMI (KOTAK KARTU MISTERIUS) TEMA PELESTARIAN LINGKUNGAN UNTUK MENINGKATKAN HASIL BELAJAR KOGNITIF
Authors: Nuralisa Siti Fatimah , Vitasari Mudmainah , Nestiadi Adi 
Published: May 2021

Proses pembelajaran dengan bantuan media pembelajaran akan meningkatkan hasil belajar kognitif yang optimal. Media pembelajaran yang dapat diaplikasikan dikelas dan dapat digunakan siswa dengan berdiskusi mengenai suatu permasalahan yang berkaitan dengan pencemaran lingkungan, sehingga siswa bisa memahami dan menerapkan upaya untuk melestarikan lingkungannya, media tersebut adalah media pembelajaran Kokami (kotak kartu misterius). Penelitian ini bertujuan untuk mengembangkan, mengetahui kevalidan dan kepraktisan pada media pembelajaran Kokami tema pelestarian lingkungan. Penelitian ini dilakukan pada bulan November 2020. Metode penelitian yang digunakan adalah Research and Development R&D, desain penelitian menggunakan desain Borg & Gall (2003) dan sampel penelitian menggunakan 40 siswa kelas VII SMP Negeri 1 Menes. Instrumen yang digunakan adalah lembar validasi untuk uji kevalidan yang dilakukan oleh 3 validator yaitu ahli media, ahli materi dan guru mata pelajaran IPA, serta angket respons siswa untuk uji kepraktisan. Hasil penelitian dan pengembangan menunjukan bahwa pengembangan media pembelajaran Kokami didesain berbeda dari pengembangan sebelumnya dilihat dari komponen, materi dan inovasi baru yang dibuat peneliti. Hasil uji kevalidan oleh tiga validator memiliki nilai rata-rata 92,9%, dengan kriteria “Sangat Baik” artinya valid dapat diuji coba. Hasil uji kepraktisan media pembelajaran Kokami pada respons siswa menghasilkan nilai rata-rata 96,5% dengan kriteria “Sangat Baik”.
Multifactorial Wrist Pain Treated with Tenotomy of Anomalous Flexor Carpi Radialis Brevis
Authors: Bernstein Ethan , Leonardelli Dominic , Pulos Nicholas 
Published: May 2021

Case:
We present a case of a 33-year-old left hand–dominant/right hand–involved active duty Navy sailor woman with volar radial wrist pain. She underwent scaphoid cyst excision and bone grafting as well as tenotomy. Intraoperatively, she was noted to have a flexor carpi radialis brevis (FCRB) tendon that was transected. After surgery, her 1-year outcomes demonstrated range of motion improved equivalent with her contralateral side, her visual analogue scale (VAS) pain score had decreased to 1, and her QuickDASH and Patient-Rated Wrist Evaluation improved.

Conclusions:
Our case represents 1-year outcome after surgical release of a FCRB. Our patient's pain and functional scores exceeded the minimal clinically important difference.