bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-temperature Liquid Exfoliation of Milligram-scale Single Crystalline Few-layer β12-Borophene Sheets as Efficient Electrocatalysts for Lithium–Sulfur Batteries
Authors: Lin Haojian , Shi Haodong , Wang Zhen , Mu Yue-Wen , Li Si-Dian , Zhao Jijun , Guo Jingwei , Yang Bing , Wu Zhong-Shuai , Liu Fei 
Published: February 2021

Abstract
Two-dimensional (2D) borophene is predicted as an ideal electrode material for lithium sulfur (Li-S) batteries because of low-density, metallic conductivity, high Li-ion surface mobility and strong interface bonding energy to polysulfide. But until now, 2D borophene-based Li-S batteries have not yet been achieved due to the absence of massive synthesis method. Herein, we developed a novel low-temperature liquid exfoliation (LTLE) method for scalable synthesis of single crystalline 2D few-layer β12-borophene sheets with a \(P\stackrel{-}{6}m2\) symmetry. The as-synthesized 2D sheets were used as the polysulfide immobilizers and electrocatalysts of Li-S batteries for the first time. The resulting Li-S cells employing borophene sheets delivered a strikingly high areal capacity of 5.2 mAh cm− 2 at a high sulfur loading of 7.8 mg cm− 2 with an ultralow capacity fading rate (0.039 % per cycle) in 1000 cycles, outperforming most of the Li-S batteries employing other 2D materials. Under the help of few-layer β12-borophene, their high-activity behaviors should be attributed to the significant enhancement of both the Li-ion’s surface migration and the adsorption energy for Li2Sn clusters based on density functional theory (DFT) models. Our research reveals great potential of 2D β12-borophene sheets in future high-performance Li-S batteries.
Mathematical Modelling of Power Skiving for General Profile based on Numerical Enveloping
Authors: Jia Kang , Guo Junkang , Ma Tao , Wan Shaoke 
Published: February 2021

Abstract
Power skiving is an effective generating machining method for internal parts like gears with respect its high productivity. The general mathematic modelling for power skiving is the basis for cutting tools design, machining precision evaluation, and machining process optimization. Currently, mainly studies are focus on the involute gear machining with adopting the analytical enveloping equation. However, these analytical methods have failed to deal with overcutting for general profile skiving tasks. Moreover, little attention has been devoted to investigate the power skiving process with taking variable configuration parameters, which is significant to control the machined surface topography. Herein, we introduce a mathematic modelling method for power skiving with general profile based on the numerical discrete enveloping. Firstly, the basic mathematic model of power skiving is established, in which the center distance is formulated as polynomial of time. With transforming the power skiving into a forming machining of the swept volume of cutting edge, a numerical algorithm is designed to distinguish the machined transverse profile via the discrete enveloping ideology. Especially, the precise instant contact curve is extracted according to the feed motion speed inversely. Finally, simulations for involute gear and cycloid wheel are carried out to verify the effectiveness of this method and investigate the influence of variable radial motions on the machined slot surface topography. The results show this method is capable to simulate the dynamic power skiving process with general profiles and to evaluate the machined results.
Tranexamic Acid Administration for the Prevention of Blood Loss After Vaginal Delivery in a High-Risk Pregnancy: A Double-blind Randomized Controlled Trial
Authors: Hasan Chro Sharef , Alalaf Shahla Kareem , Khoshnaw Sazgar Abdulla 
Published: February 2021

Abstract
Purpose: The purpose of this study was to examine the effectiveness of tranexamic acid administration for the prevention of postpartum hemorrhage in women with high-risk pregnancies. Tranexamic acid, with the recommended oxytocin, was administered in the third stage of labor to reduce vaginal blood loss and prevent postpartum hemorrhage.Methods: A double-blind randomized placebo-controlled trial with two parallel groups was conducted in women scheduled to undergo vaginal delivery at the Maternity Teaching Hospital, Erbil City, Kurdistan region, Iraq. The women were randomly assigned to receive tranexamic acid (97 women) or placebo (99 women) with oxytocin immediately after fetal delivery in the third stage of labor. We measured vaginal blood loss from fetal to placental delivery and the time from fetal to placental delivery.Results: The mean blood loss in the oxytocin alone group (group 1) was significantly higher than that in the tranexamic and oxytocin group (group 2). The incidence of postpartum hemorrhage (blood loss of ≥500 mL) and blood loss of ≥250 mL was significantly higher in group I than in group 2. The length of the third stage of labor was significantly longer in group 1 than in group 2.Conclusions: In the women who delivered vaginally and had risk factors of postpartum hemorrhage, the incidence rates of the primary outcome of postpartum hemorrhage and blood loss of <250 mL, and the time to placental delivery were significantly lower in the women who received tranexamic acid with active management of third stage labor than in those who received placebo.Trial registration number: ClinicalTrials.gov ID: NCT04201951, December 17, 2019
Cyperus Iria Aqueous-Ethanol Extract Ameliorated Hyperglycemia, Oxidative Stress and Regulated Inflammatory Cytokines in Streptozotocin Induced Diabetic Rats
Authors: Saeed Myeda , Sharif Ali , UlHassan Saeed , Akhtar Bushra , Muhammad Faqir , Malik Maryam 
Published: February 2021

Abstract
Present study is involved in identification of biophenolic and flavonoids from the aqueous-ethanol extract of Cyperus iria and appraisal of inflammatory and stress markers involved in endocrine dysfunction based upon its folktale use. Significantly higher quantities of phenolic (82.79 ± 0.003 mg/g GAE) and flavonoid (13.61 ± 0.002 mg/g QE) contents were present. Inhibitory concentration (IC50) exhibited an excellent potential for both antioxidant (IC50 = 3.22 µg/mL) and alpha amylase (IC50 = 36.29 µg/mL) inhibitory assays. High performance liquid chromatography (HPLC), confirmed the existence of myercetin, quercetin, kaempferol and ferullic acid. Cyperus iria aqueous-ethanol extract exhibits good tolerance against glucose. Streptozotocin induced hyperglycemia declined along with improvement in inflammatory (TNF-α = 15.6 ± 0.2 g/l, COX-2 = 357 ± 0.396 U/l, IL-6 = 572 ± 0.99 pg/l) and oxidative stress markers (SOD = 163 ± 0.616 and GSH-ST = 95.8 ± 0.44 U/mL) along with biochemical parameters in a dose-dependent manner. Present study suggests that Cyperus iria aqueous-ethanol extract possess hypoglycemic potential which might be attributed to the presence of phenolics and flavonoids.
Effect of Cognitive Behavioral Therapy-Based Counseling on Perceived Stress in Pregnant Women with History of Primary Infertility: A Controlled Randomized Clinical Trial
Authors: Golshani Farideh , Hasanpour Shirin , Mirghafourvand Mojgan , Esmaeilpour Khalil 
Published: February 2021

Abstract
BackgroundGiven the prevalence of infertility and consequences of stress, anxiety, and depression during pregnancy and after childbirth, this study aimed to determine the effect of cognitive behavioral therapy (CBT)-based counseling on perceived stress (primary outcome), anxiety, depression, and quality of life (QoL) of pregnant women with a history of primary infertility (secondary outcome).Method:This controlled randomized clinical trial was conducted on 56 pregnant women with a history of primary infertility referred to Infertility Clinic of Al-Zahra Teaching Hospital of Tabriz. The participants were divided into the intervention (n = 28) and control (n = 28) groups using block randomization. The intervention group received group CBT-based counseling after the 14th week of the pregnancy: six in-person sessions and two telephone sessions once per week. The control group received routine care. The Perceived Stress Scale (PSS), Edinburgh Postnatal Depression Scale (EPDS), Van den Bergh’s Pregnancy-Related Anxiety Questionnaire (PRAQ), and Quality of Life in Pregnancy (Gravidarum) (QOL-GRAV) were completed through interviews before and four weeks after the intervention by the researcher.ResultsThere was not any between-group difference in socio-demographic characteristics, except the gestational age and husband educational level (p > 0.05). Both of these variables were adjusted in ANCOVA. After the intervention, the mean scores of perceived stress (mean difference: -7.3; confidence interval: 95%, from − 0.9 to -5.6; p < 0.001) and anxiety (mean difference:-14.7; confidence interval: 95%. from − 20.6 to − 8.8; p < 0.001) were significantly lower in the intervention group. The mean depression score in the intervention group was lower than the control; however, this between-group difference was not significant (mean difference: -1.95; confidence interval: 95% from − 3.9 to 0.2; p = 0.052). The mean score of quality of life in pregnancy was significantly higher in the intervention group than the control (mean difference: -5.4; confidence interval: 95% from 3.4 to 7.4; p < 0.001).ConclusionCBT counseling can affect the perceived stress, anxiety, and quality of life of pregnant women with a history of primary infertility. As a result, this counseling approach is recommended along with other counseling approaches to improve the mental health of pregnant women with a history of infertility.Trial RegistrationIRCT Registration Number: IRCT20111219008459N12, registered on 10/11/ 2018 (https://irct.ir/user/trial/34677)
Manganese in potable water of nine districts, Bangladesh: Human health risk
Authors: Rahman Md. Aminur , Hashem Md. Abul , Rana Md. Sohel , Islam Md. Rashidul 
Published: February 2021

Abstract
Safe drinking water is directly linked to good human health. An excessive amount of manganese (Mn) in drinking water supplies causes people show symptoms of neurotoxicity. In this study, the level of Mn in potable water sourced from tube wells located in 9 (nine) districts of Bangladesh was monitored. In total 170 (one hundred and seventy) water samples were collected and Mn was quantified by atomic absorption spectroscopy (AAS). The levels of Mn found in the tube well water samples of Sirajganj, Meherpur, Chuadanga, Jhenaidah, Magura, Faridpur, Jashore, Satkhira, and Khulna were 0.37–1.86, 0.10–4.11, 0.30–0.76, 0.26–0.94, 0.01–0.18, 0.21–1.78, 0.08–1.23, 0.05–0.27 and 0.01–2.11 mg/L, respectively. Results revealed that Mn level was beyond the highest contaminated levels of 0.1 mg/L and 0.4 mg/L, which are recommended by Bangladesh Drinking Standard (BDS) and World Health Organization (WHO), respectively. The maximum Mn contaminated level reached up to 4.11 mg/L (mean: 0.53 mg/L). The Mn level in tube well water exceeded 51.1% and 75.9% set by the recommended value of WHO and BDS, respectively. Furthermore, the calculated hazard quotient (HQ) value for Mn was observed to be greater than unity, indicating both children and adults risked potential non-carcinogenic health issues. The water supply authorities should take steps to provide Mn-free drinking water for communities.
Genetic analysis by targeted next-generation sequencing and novel variation identification of maple syrup urine disease
Authors: Fang Xiaohua , Zhu Xiaofan , Feng Yin , Bai Ying , Zhao Xuechao , Kong Xiangdong , Liu Ning 
Published: February 2021

Abstract
Maple syrup urine disease (MSUD) is a rare autosomal recessive disorder that affects the degradation of branched chain amino acids (BCAAs). Only a few cases of MSUD have been documented in Mainland China. In this report, 8 patients (4 girls and 4 boys) with MSUD from 8 unrelated Chinese families were diagnosed at the age of 9 days to 1 year and 8 months. All the coding regions and exon/intron boundaries of BCKDHA, BCDKHB, DBT, DLD genes were analyzed by targeted NGS in the 8 MSUD pedigrees. Targeted NGS revealed 2 pedigrees with MSUD Ia, 5 pedigrees with Ib, 1 pedigree with MSUD II. Totally, 13 variants were detected, including 2 variants (p.Ala216Val and p.Gly281Arg) in BCKDHA gene，10 variants (p.Gly95Ala, p.Ser171Pro, p.Phe175Leu, p.Arg183Trp, p.Lys222Thr, p.Arg285Ter，p.Arg111Ter，p.S184Pfs*46, p.Arg170Cys, p.I160Ffs*25) in BCKDHB gene, 1 variants (p.Arg431Ter) in DBT gene. In addition, 4 previously unidentified variants (p.Gly281Arg in BCKDHA gene, p.Ser171Pro, p.Gly95Ala and p.Lys222Thr in BCKDHB gene) were found. NGS plus Sanger sequencing detection is effective and accurate for making gene diagnosis. Computational structural modeling indicated that these novel variations might affect structural stability.
Investigating the Burden of Mental Distress Among Nurses at A Provincial COVID-19 Referral Hospital In Indonesia: A Cross-Sectional Study
Authors: Marthoenis Marthoenis , Maskur Maskur , Fathiariani Liza , Nassimbwa Jacqueline 
Published: February 2021

Abstract
Background: The current outbreak of COVID-19 pandemic distorts not only the physical, but also mental and psychological condition of healthcare providers, especially the nurses who directly working with the COVID-19 patients. This study aims to investigate the prevalence and risk factors of depression, anxiety and stress among nurses working in a COVID-19 referral hospital in Indonesia. Methods: A cross-sectional study was conducted. A self-administered questionnaire, DASS21, along with the demographic questions was used to screen the presence of psychological problems and their associated factors. Results: the prevalence of moderate to extremely severe depression, anxiety and stress was 8.7%, 20.7% and 5.8%, respectively. The prevalence rate was significantly higher among those with financial hardship during the COVID-19 pandemic, with 10.5%, 23.5% and 8.1% for depression, anxiety and anxiety (P<.05), respectively. Regression analysis confirmed that these mental problems were associated with the experience of social rejection, either by family or neighbor, because they were working in the hospital during the pandemic. Conclusions: The financial hardship experienced by the nurses during disease pandemic increases their burden of mental illness therefore, providing the financial subsidiary might reduce their financial uncertainty. Furthermore, the motivation to have a positive attitude toward the pandemic, promotion of healthy behavior such as the use of face mask and the provision of sufficient information on the diseases, may help them properly manage their mental distress.
Self-esteem, job insecurity and psychological distress among Chinese nurses
Authors: liu yun , yang chunyan , zou guiyuan 
Published: February 2021

Abstract
Background
Many studies have investigated the related variables of nurses’ psychological distress, but little is known about the underlying mechanism between job insecurity, self-esteem and psychological distress.
Aims
The purpose of this study examined the role of self-esteem as a mediator between job insecurity and psychological distress among Chinese nurses.
Methods
Questionnaires, assessing job insecurity, self-esteem and psychological distress, were collected from 462 nurses at a third-grade class-A hospital in Shandong Province, China.
Results
Results showed that the prevalence of psychological distress among nurses was 83.8%. Regression analysis showed that job insecurity was positively associated with psychological distress, explaining 17.5% of variance in psychological distress. Mediation analysis showed that self-esteem partially mediated the effect of the two dimensions of job insecurity on psychological distress.
Conclusions
Nurses with low self-esteem and high job insecurity deserved attention. Programs that reduce uncertainty and increase predictability and cultivate a supportive, cooperative work climate may promote nurse overall health and foster self-esteem.
Distinct Microbial Communities Colonize Tonsillar Squamous Cell Carcinoma
Authors: Ludewig Burkhard , Martin Angelina De , Lütge Mechthild , Stanossek Yves , Engetschwiler Céline , Cupovic Jovana , Brown Kirsty , Demmer Izadora , Broglie Martina A. , McCoy Kathy , Geuking Markus , Jochum Wolfram , Stoeckli Sandro J. 
Published: February 2021

Abstract
Background: Squamous cell carcinoma of the tonsil is one of the most frequent cancers of the oropharynx. The escalating rate of tonsil cancer during the last decades is associated with the increase of high risk-human papilloma virus (HR-HPV) infections. While the microbiome in oropharyngeal malignant diseases has been characterized to some extent, the microbial colonization of HR-HPV-associated tonsil cancer remains largely unknown.Results: Using 16S rRNA gene amplicon amplicon sequencing, we have characterized the microbiome of human palatine tonsil crypts in patients suffering from HR-HPV-associated tonsil cancer in comparison to an age-matched control cohort of sleep apnea patients. We found an increased abundance of the phyla Firmicutes and Actinobacteria in tumor patients, whereas the abundance of Spirochaetes and Synergistetes was significantly higher in the control cohort. Furthermore, the accumulation of several genera such as Veillonella, Streptococcus and Prevotella_7 in tonsillar crypts was associated with tonsil cancer. In contrast, Fusobacterium, Prevotella and Treponema_2 were enriched in sleep apnea patients. Machine learning-based bacterial species analysis indicated that a particular bacterial composition in tonsillar crypts is tumor-predictive. Species-specific PCR-based validation in extended patient cohorts confirmed that differential abundance of Filifactor alocis and Prevotella melaninogenica is a distinct trait of tonsil cancer.Conclusion: This study shows that tonsil cancer patients harbor a characteristic microbiome in the crypt environment that differs from the microbiome of sleep apnea patients on all phylogenetic levels. Moreover, our analysis indicates that profiling of microbial communities in distinct tonsillar niches provides microbiome-based avenues for the diagnosis of tonsil cancer.
Free electron Compton scattering produces the illusion of the universe expansion
Authors: Cheng GuanFeng 
Published: February 2021

Abstract
Because it is consistent with many astronomical phenomena and successfully predicted the cosmic microwave background radiation (CMBR) and cosmic abundance, the theory of universe expansion has been widely recognized by the scientific community. Hubble's law is the foundation of universe expansion theory, but 100 years of observations have shown that Hubble parameters are not constants, and with the improvement of Hubble parameter measurement accuracy, the problem of inconsistent Hubble parameters obtained by different star types and different methods has become more and more difficult to solve. So the cosmological redshift may not only be related to distance but also to other factors, and the universe may not be really expanding. The Compton effect of free electrons and low energy photons has been observed in the laboratory. Photons interact with a large number of free electrons on their way to us from a distant source (free electron Compton scattering FEC). FEC causes photons (plane electromagnetic waves) to redshift, and the photon beam to expand along the propagation direction, these produce the illusion of cosmic expansion, showing the same astronomical phenomena as the expansion of the universe (FEC model).
Morphological Traits and Nutrient Uptake of Dragon’s Head (Lallemantia Iberica Fish.): Effects of Sowing Seasons and Different Fertilizer Sources
Authors: Maddahi Shayesteh , Rahimi Amir , Moghaddam Sina Siavash , Pourakbar Latifeh , Popović-Djordjević Jelena 
Published: February 2021

Abstract
The effects of sowing seasons and chemical, organic and biological fertilizer sources were explored on morphological traits of dragon’s head (Lallemantia iberica Fish.) in a field experiment based on a randomized complete block design in three replications and six treatments. The fertilization treatments included organic fertilizers (vermicompost, manure, and humic acid), biological fertilizer (Thiobacillus mixed with sulfur), chemical fertilizer (macro NPK), and control (no-fertilization). The recorded traits included leaf area index, plant height, number of flower cycles per plant, number of achenes per plant, number of seeds per plant, 1000-seed weight, number of auxiliary branches, plant diameter, and the uptake of nitrogen, potassium, phosphorus, calcium, and sodium. The results showed that the winter sowing outperformed the spring sowing by a wide margin and results obtained for morphological traits were significantly higher than those of the spring sowing. The fertilization of the plants in both sowing seasons, especially in the winter sowing, improved yield and yield components. The uptake of N and K was not influenced by the sowing season and fertilizer type, whereas the uptake of P, Ca, and Na was influenced by these factors but with a slight difference. It can, so, be inferred that the uptake of nutrients in dragon’s heads is less influenced by the environment. Overall results indicated that the improvement of morphological traits in the ecological conditions of Azerbaijan region (Iran) was most notable for winter sowing of dragon’s heads with the use of Thiobacillus and vermicompost fertilizers.
A Likelihood Ratio Test For The Homogeneity of Between-Study Variance in Network Meta-Analysis
Authors: Hu Dapeng , Wang Chong , O'Connor Annette 
Published: February 2021

Abstract
Background: Network meta-analysis (NMA) is a statistical method used to combine results from several clinical trials and simultaneously compare multiple treatments using direct and indirect evidence. Statistical heterogeneity is a characteristic describing the variability in the intervention effects being evaluated in the different studies in network meta-analysis. One approach to dealing with statistical heterogeneity is to perform a random effects network meta-analysis that incorporates a between-study variance into the statistical model. A common assumption in the random effects model for network meta-analysis is the homogeneity of between-study variance across all interventions. However, there are applications of NMA where the single between-study assumption is potentially incorrect and instead the model should incorporate more than one between-study variances. Methods: In this paper, we develop an approach to testing the homogeneity of between-study variance assumption based on a likelihood ratio test. A simulation study was conducted to assess the type I error and power of the proposed test. This method is then applied to a network meta-analysis of antibiotic treatments for Bovine respiratory disease (BRD). Results: The type I error rate was well controlled in the Monte Carlo simulation. The homogeneous between-study variance assumption is unrealistic both statistically and practically in the network meta-analysis BRD. The point estimate and conffdence interval of relative effect sizes are strongly inuenced by this assumption. Conclusions: Since homogeneous between-study variance assumption is a strong assumption, it is crucial to test the validity of this assumption before conducting a network meta-analysis. Here we propose and validate a method for testing this single between-study variance assumption which is widely used for many NMA.