bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local low-rank approach to nonlinear-matrix completion
Authors: Sasaki Ryohei , Konishi Katsumi , Takahashi Tomohiro , Furukawa Toshihiro 
Published: January 2021

Abstract
This paper deals with a problem of matrix completion in which each column vector of the matrix belongs to a low-dimensional differentiable manifold (LDDM), with the target matrix being high or full rank. To solve this problem, algorithms based on polynomial mapping and matrix-rank minimization (MRM) have been proposed; such methods assume that each column vector of the target matrix is generated as a vector in a low-dimensional linear subspace (LDLS) and mapped to a p-th order polynomial, and that the rank of a matrix whose column vectors are d-th monomial features of target column vectors is defficient. However, a large number of columns and observed values are needed to strictly solve the MRM problem using this method when p is large; therefore, this paper proposes a new method for obtaining the solution by minimizing the rank of the submatrix without transforming the target matrix, so as to obtain high estimation accuracy even when the number of columns is small. This method is based on the assumption that an LDDM can be approximated locally as an LDLS to achieve high completion accuracy without transforming the target matrix. Numerical examples show that the proposed method has a higher accuracy than other low-rank approaches.
Correlates of premature pap test screening, under 25 years old: Analysis of data from the CONSTANCES cohort study.
Authors: Mignot Stephanie , Ringa Virginie , Vigoureux Solène , Zins Marie , Panjo Henri , Saulnier Pierre-Jean , Fritel Xavier 
Published: January 2021

Abstract
Background: Many countries currently recommend that screening for cervical cancer begin at the age of 25 years. Premature screening (before that age) could lead to unnecessary follow-up examinations and procedures that turn out to be useless. Our objective is to ascertain if the use of particular contraceptive methods are associated with premature screening. Methods: This cross-sectional study based on the CONSTANCES cohort enabled us to include 4297 women younger than 25 years. The factors associated with premature screening were modeled by logistic regression. Missing data were handled by multiple imputations . The multivariate analyses were adjusted for sex life, social and demographic characteristics, and health status . Results: Nearly half (48.5%) the women younger than 25 years had already undergone premature screening. Women not using contraceptives (aOR 0.3, 95% CI 0.3-0.5) and those using nonmedicalized contraceptives (condom, spermicide, etc.) (aOR 0.5, 95% CI 0.4-0.6) had premature screening less often than women using birth control pills. Higher risks of premature screening were observed in 20-year-old women (aOR 2.7, 95% CI 2.2-3.3) and in those with more than 5 lifetime partners (aOR 2.5, 95% CI 2.0-3.1), compared respectively with those of women who were younger and those with 5 or fewer lifetime partners. Conclusion: Young women using contraceptives that require a doctor's prescription are exposed to premature screening more often than both those not using contraception and those with nonmedicalized contraceptives.
Clinical utility of procalcitonin in febrile infants younger than 3 months of age visiting a pediatric emergency room: A retrospective single-center study
Authors: park Jun Sung , Byun Young-Hoon , Lee Jeong-Yong , Lee Jong Seung , Ryu Jeong-Min , Choi Seung Jun 
Published: January 2021

Abstract
BackgroundFever in infants under 90 days of age is highly likely to be caused by a severe bacterial infection (SBI) and it accounts for a large number of patients visiting the pediatric emergency room. In order to predict the bacterial infection and reduce unnecessary treatment, the classic classification system is based on white blood cell (WBC) count, urinalysis, and x-ray, and it is modified and applied at each center by incorporating recently studied biomarkers such as c-reactive protein (CRP) or procalcitonin (PCT). This study analyzed the usefulness of PCT in predicting SBI when applied along with the existing classification system, including CRP, among infants less than 90 days old who visited with a fever at a single institution pediatric emergency center.MethodsWe retrospectively reviewed the medical records of patients younger than 3 months of age who presented with fever at the Seoul Asan Medical Center pediatric emergency room between July 2017 and October 2018.ResultsA total of 317 patients were analyzed, and 61 were diagnosed with SBI, among which urinary tract infection (UTI) accounted for the largest proportion (55/61, 90.2%). There were differences in WBC, neutrophil proportion, CRP, and PCT between the SBI group and the non-SBI group, and the AUC values of WBC, CRP, and PCT were 0.651, 0.804, and 0.746, respectively. When using the cut-off values of CRP and PCTs as 2.0 mg/dL and 0.3 ng/mL, respectively, the sensitivity and specificity for SBI were 49.2/89.5, and 54.1/87.5, respectively. WBC, CRP, and PCT were statistically significant for predicting SBI in multivariate analysis (odds ratios 1.066, 1.377, and 1.291, respectively). When the subjects were classified using the existing classification criteria, WBC and CRP, the positive predictive value (PPV) and negative predictive value (NPV) were 29.3% and 88.7%, respectively, and when PCT was added, the PPV and NPV were 30.7% and 92%, respectively, both increased.ConclusionPCT is useful for predicting SBI in children aged 3 months or less who visit the emergency room with a fever. It is useful as a single biomarker, and when used in conjunction with classic biomarkers, its diagnostic accuracy is further increased.
Assessment of China's Contribution in Regional Network for Asian Schistosomiasis: a questionnaire survey
Authors: Li Hongmei , Qian Yingjun , Yang Kun , Ding Wei , Huang Lulu , Ma Xuejiao , Duan Lei , Wang Duoquan , Guan Yayi , Xiao Ning , Zhou Xiao-Nong 
Published: January 2021

Abstract
Background: The Regional Network for Asian Schistosomiasis and other Helminth Zoonoses (RNAS+) launched in 1998, has close partnerships with countries endemic for schistosomiasis and other helminthiasis. RNAS+ has provided an ideal regional platform for policy-making, control, and parasitic diseases research experts in Asian countries. China, one of the initiating countries, has provided significant technical and financial support to the regional network. Although Chinese institutions and other member countries provided great technical and resource support in RNAS+ development, China, and Chinese scientists or institutions’ contributions, have not been evaluated systematically. This study assessed Chinese contributions toward supporting RNAS+ development.Methods: An assessment research framework was planned to evaluate China’s contribution to RNAS+ in four aspects, including capacity building, funding support, coordination, and cooperation. An anonymous web-based questionnaire was designed to acquire respondents’ basic information, and information on China’s contributions, challenges, and recommendations for RNAS+ development. Each participant scored from 0 to 10 to assess China’s contribution: “0” no contribution, and “10” 100% contribution. Participants who included their e-mail address in the 2017 - 2019 RNAS+ annual workshops were invited to participate the assessment.Results: Of 71 participants enrolled, 41 responded to the survey, 37 (37/41, 90.24%) of whom were from RNAS+ member countries while the remaining 4 (4/41, 9.76%) were international observers. Most respondents (38/41, 92.68%) are familiar with RNAS+. Respondents reported that China’s contributions were mainly to improve capacity building, and provide funding support, coordination responsibility, and joint application of the cooperation program towards RNAS+ development. The average scores of China’s contributions in the above four fields were 8.92, 8.64, 8.75, and 8.67, respectively, with an overall assessment score of 8.81 (10 maximum score). The challenge of RNAS+ includes the lack of sustainable funding and skills, and most participants indicated their continual need of China’s support.Conclusions This survey showed that China plays an important role in the development of RNAS+. This network-type organization for disease control and research can yet be regarded as a great potential pattern for China to enhance regional cooperation. These findings can be used to promote future cooperation between China and other RNAS+ member countries.
Serine Proteases Profiles of Leishmania (Viannia) Braziliensis Clinical Isolates With Distinct Susceptibilities to Antimony
Authors: Zabala-Peñafiel Anabel , Dias-Lopes Geovane , Cysne-Finkelstein Léa , Conceição-Silva Fátima , Miranda Luciana de Freitas Campos , Fagundes Aline , Schubach Armando de Oliveira , Pimentel Maria Ines Fernandes , Souza-Silva Franklin , Machado Lucas de Almeida , Alves Carlos Roberto 
Published: January 2021

Abstract
Glucantime® (SbV) is the first-line treatment against leishmaniasis in South America. Its effectiveness has been associated with modulation of the parasite detoxification system that, in turn, is related to serine proteases such as subtilisins. In this study, 12 Leishmania (Viannia) braziliensis isolates from patients that presented clinical cure (Responders - R) and relapse or therapeutic failure (Non-responders - NR) were used. The parasites were assessed by in vitro susceptibility to SbIII and SbV, serine proteases activity – measured with z-FR-AMC as substrate and specific inhibitors – and expression of subtilisins and tryparedoxin-peroxidase (TXNPx). In vitro susceptibility of axenic amastigotes to SbIII showed a significant difference between R and NR groups. TLCK inhibited almost 100 % of activity in both axenic amastigotes and promastigotes while AEBSF inhibited around 70 %, and PMSF showed lower inhibition of specific isolates. Principal component and clustering analysis yielded one homogeneous cluster with only NR isolates and three heterogeneous clusters with R and NR isolates. Additionally, transcripts of subtilisins (LbrM.13.0860 and LbrM.28.2570) and TXNPx (LbrM.15.1080) were detected in promastigotes and axenic amastigotes from both groups. The data presented here show a phenotypic heterogeneity among the parasites, suggesting that exploration of in vitro phenotypes based on SbIII and serine proteases profiles can aid in the characterization of L. (V.) braziliensis clinical isolates.
Spatio-temporal analysis of sediment yield with a physically based model for a data-scarce headwater in Konya Closed Basin, Turkey
Authors: Koycegiz Cihangir , Buyukyildiz Meral , Kumcu Serife Yurdagul 
Published: January 2021

Abstract
There are many empirical, semi-empirical and mathematical methods that have been developed to estimate sediment yield by researchers. In the last decades, the advancement in computer technologies has increased the use of mathematical models as they can solve the system more rapidly and accurately. The Soil and Water Assessment Tool (SWAT) is one of the physically based hydrological models that is preferred to compute sediment yield. In this study, spatial and temporal analysis of sediment yield in the Çarşamba Stream located at the Konya Closed Basin has been investigated using the SWAT model. Streamflow and sediment data collected during the 2003–2015 time period have been used in the analysis. Consequently, the SWAT presented satisfactory results compared with R2 = 0.68, Nash–Sutcliffe Efficiency (NSE) = 0.68 in calibration and R2 = 0.76, NSE = 0.66 in validation. According to the model results, spatial asymmetry in terms of sediment yield was determined in the sub-basins of the study area.
Habits Heart App for Patient Engagement in Heart Failure Management: Pilot Feasibility Randomized Trial
Authors: Wei Kevin S , Ibrahim Nasrien E , Kumar Ashok A , Jena Sidhant , Chew Veronica , Depa Michal , Mayanil Namrata , Kvedar Joseph C , Gaggin Hanna K 
Published: January 2021

Background
Due to the complexity and chronicity of heart failure, engaging yet simple patient self-management tools are needed.

Objective
This study aimed to assess the feasibility and patient engagement with a smartphone app designed for heart failure.

Methods
Patients with heart failure were randomized to intervention (smartphone with the Habits Heart App installed and Bluetooth-linked scale) or control (paper education material) groups. All intervention group patients were interviewed and monitored closely for app feasibility while receiving standard of care heart failure management by cardiologists. The Atlanta Heart Failure Knowledge Test, a quality of life survey (Kansas City Cardiomyopathy Questionnaire), and weight were assessed at baseline and final visits.

Results
Patients (N=28 patients; intervention: n=15; control: n=13) with heart failure (with reduced ejection fraction: 15/28, 54%; male: 20/28, 71%, female: 8/28, 29%; median age 63 years) were enrolled, and 82% of patients (N=23; intervention: 12/15, 80%; control: 11/13, 85%) completed both baseline and final visits (median follow up 60 days). In the intervention group, 2 out of the 12 patients who completed the study did not use the app after study onboarding due to illnesses and hospitalizations. Of the remaining 10 patients who used the app, 5 patients logged ≥1 interaction with the app per day on average, and 2 patients logged an interaction with the app every other day on average. The intervention group averaged 403 screen views (per patient) in 56 distinct sessions, 5-minute session durations, and 22 weight entries per patient. There was a direct correlation between duration of app use and improvement in heart failure knowledge (Atlanta Heart Failure Knowledge Test score; ρ=0.59, P=.04) and quality of life (Kansas City Cardiomyopathy Questionnaire score; ρ=0.63, P=.03). The correlation between app use and weight change was ρ=–0.40 (P=.19). Only 1 out of 11 patients in the control group retained education material by the follow-up visit.

Conclusions
The Habits Heart App with a Bluetooth-linked scale is a feasible way to engage patients in heart failure management, and barriers to app engagement were identified. A larger multicenter study may be warranted to evaluate the effectiveness of the app.

Trial Registration
ClinicalTrials.gov NCT03238729; http://clinicaltrials.gov/ct2/show/NCT03238729
Medication Management Service for Old Age Homes in Hong Kong Using Information Technology, Automation Technology, and the Internet of Things: Pre-Post Interventional Study
Authors: So Kei Hong , Ting Cheuk Wun , Lee Chui Ping , Lam Teddy Tai-Ning , Chiang Sau Chu , Cheung Yin Ting 
Published: January 2021

Background
Innovation in technology and automation has been increasingly used to improve conventional medication management processes. In Hong Kong, the current practices of medication management in old age homes (OAHs) are time consuming, labor intensive, and error prone. To address this problem, we initiated an integrated medication management service combining information technology, automation technology, and the Internet of Things in a cluster network of OAHs.

Objective
This pilot study aimed to evaluate the impact of the medication management program on (1) medication management efficiency, (2) medication safety, and (3) drug wastage in OAHs. We compared the time efficiency and the reductions in medication errors and medication wastage in OAHs before and at least 2 weeks after the implementation of the program.

Methods
From November 2019 to February 2020, we recruited 2 OAHs (serving 178 residents) in Hong Kong into the prospective, pre-post interventional study. The interventional program consisted of electronic medication profiles, automated packaging, and electronic records of medication administration. Using 3-way analysis of variance, we compared the number of doses prepared and checked in 10-minute blocks before and after implementation. We received anonymous reports of medication errors from OAH staff and analyzed the results with the Fisher exact test. We also calculated the quantity and cost of wasted medications from drug disposal reports.

Results
The number of doses prepared and checked in 10-minute blocks significantly increased postimplementation (pre: 41.3, SD 31.8; post: 70.6, SD 22.8; P<.001). There was also a significant reduction in medication errors (pre: 10/9504 doses, 0.1%; post: 0/5731 doses; P=.02). The total costs of wasted medications during January 2020 in OAH 1 (77 residents) and OAH 2 (101 residents) were HK $2566.03 (US $328.98) and HK $5249.48 (US $673.01), respectively.

Conclusions
Our pilot study suggested that an innovative medication management program with information technology, automation technology, and Internet of Things components improved the time efficiency of medication preparation and medication safety for OAHs. It is a promising solution to address the current limitations in medication management in OAHs in Hong Kong.
Dynamic Panel Data Modeling and Surveillance of COVID-19 in Metropolitan Areas in the United States: Longitudinal Trend Analysis
Authors: Oehmke Theresa B , Post Lori A , Moss Charles B , Issa Tariq Z , Boctor Michael J , Welch Sarah B , Oehmke James F 
Published: January 2021

Background
The COVID-19 pandemic has had profound and differential impacts on metropolitan areas across the United States and around the world. Within the United States, metropolitan areas that were hit earliest with the pandemic and reacted with scientifically based health policy were able to contain the virus by late spring. For other areas that kept businesses open, the first wave in the United States hit in mid-summer. As the weather turns colder, universities resume classes, and people tire of lockdowns, a second wave is ascending in both metropolitan and rural areas. It becomes more obvious that additional SARS-CoV-2 surveillance is needed at the local level to track recent shifts in the pandemic, rates of increase, and persistence.

Objective
The goal of this study is to provide advanced surveillance metrics for COVID-19 transmission that account for speed, acceleration, jerk and persistence, and weekly shifts, to better understand and manage risk in metropolitan areas. Existing surveillance measures coupled with our dynamic metrics of transmission will inform health policy to control the COVID-19 pandemic until, and after, an effective vaccine is developed. Here, we provide values for novel indicators to measure COVID-19 transmission at the metropolitan area level.

Methods
Using a longitudinal trend analysis study design, we extracted 260 days of COVID-19 data from public health registries. We used an empirical difference equation to measure the daily number of cases in the 25 largest US metropolitan areas as a function of the prior number of cases and weekly shift variables based on a dynamic panel data model that was estimated using the generalized method of moments approach by implementing the Arellano-Bond estimator in R.

Results
Minneapolis and Chicago have the greatest average number of daily new positive results per standardized 100,000 population (which we refer to as speed). Extreme behavior in Minneapolis showed an increase in speed from 17 to 30 (67%) in 1 week. The jerk and acceleration calculated for these areas also showed extreme behavior. The dynamic panel data model shows that Minneapolis, Chicago, and Detroit have the largest persistence effects, meaning that new cases pertaining to a specific week are statistically attributable to new cases from the prior week.

Conclusions
Three of the metropolitan areas with historically early and harsh winters have the highest persistence effects out of the top 25 most populous metropolitan areas in the United States at the beginning of their cold weather season. With these persistence effects, and with indoor activities becoming more popular as the weather gets colder, stringent COVID-19 regulations will be more important than ever to flatten the second wave of the pandemic. As colder weather grips more of the nation, southern metropolitan areas may also see large spikes in the number of cases.
Hubungan antara Minat dan Kebahagiaan menjadi Perajin Ukir Kayu Jepara
Authors: Achmad Tasylichul Adib 
Published: January 2021

Since 2004-2015, there has been a decline in the number of Jepara woodcarvers. This phenomenon is allegedly caused by the lack of interest as woodcarvers. Ironically, those who are survive today, actually sell the carving at any price. The study about woodcarvers happiness was conducted to determine the effect of interest on happiness based on socioeconomic characteristics. The population of this study was all of the small-micro wood carving industries. The sampling was carried out using the stratified systematic sampling method with sample framework SE 2016 listing data. A total of 837 industry were allocated to 100 industry and were stratified into centers of 53 industries and non-centers of 47 industries. The analytical method used descriptive analysis and inferencing analysis. This study revealed that interest has a tendency to influence woodcarvers happiness, but the amount of income becomes its highest factor.
Akses Pasangan Usia Subur (PUS) Miskin terhadap Informasi Keluarga Berencana (KB) di Kota Yogyakarta
Authors: Fitriana Putri Utami , Ratu Matahari , Sri Sugiharti 
Published: January 2021

The government’s effort to overcome the high rate of population growth is implementing a family planning program. However, limited access to family planning is undergone by poor population in very great numbers. One factor causing poor couples of childbearing age not to become a family planning acceptor is the limited sources or access to information related to the family planning program. This study aims to find out how poor couples of childbearing age accessed information related to family planning as an initial step to increase family planning acceptors in Yogyakarta. This study used a mixed research method, i.e. quantitative and qualitative designs. Quantitative design was carried out by distributing questionnaires to 368 poor couples of childbearing age selected by using simple random sampling. Qualitative design was carried out with in-depth interviews with six poor couples of childbearing age as well as focus group discussion (FGD) on family planning officers and companions of the Program Keluarga Harapan (PKH) which were selected purposively. The results of this study were analyzed descriptively and content analysis. The majority of poor couples of childbearing age obtained information on contraceptive methods and free family planning program from midwives in primary health care. Delivered information in the form of home visits was only obtained by 7.3% of respondents. The obstacle experienced by family planning officers and PKH companions in delivered family planning information was the assumption that many children have lots of fortune and certain belief factors that prohibit the use of contraception. There was a need for training on interesting educational methods to PKH companion and health cadres to be forwarded to childbearing couples and the existence of media for family planning education as a guide.