bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Oxalate Concentrations Correlate with Increased Risk for Sudden Cardiac Death in Dialysis Patients
Authors: Pfau Anja , Ermer Theresa , Coca Steven G. , Tio Maria Clarissa , Genser Bernd , Reichel Martin , Finkelstein Fredric O. , März Winfried , Wanner Christoph , Waikar Sushrut S. , Eckardt Kai-Uwe , Aronson Peter S. , Drechsler Christiane , Knauf Felix 
Published: July 2021

Significance Statement
Oxalate is a toxic end product of metabolism that is highly elevated in patients with kidney failure requiring chronic dialysis. Basic research has demonstrated that oxalate is a potential trigger of systemic inflammation, progression of CKD, and cardiovascular complications. The authors conducted a post-hoc analysis of the randomized German Diabetes Dialysis Study of 1255 European patients with diabetes on hemodialysis. In their analysis of 1108 patients, they found those with higher serum oxalate concentrations were more likely than those with lower levels of serum oxalate to experience cardiovascular mortality, particularly sudden cardiac death. These findings suggest oxalate-lowering therapeutic strategies might have potential for decreasing cardiovascular mortality in patients with kidney disease.

Background
The clinical significance of accumulating toxic terminal metabolites such as oxalate in patients with kidney failure is not well understood.

Methods
To evaluate serum oxalate concentrations and risk of all-cause mortality and cardiovascular events in a cohort of patients with kidney failure requiring chronic dialysis, we performed a post-hoc analysis of the randomized German Diabetes Dialysis (4D) Study; this study included 1255 European patients on hemodialysis with diabetes followed-up for a median of 4 years. The results obtained via Cox proportional hazards models were confirmed by competing risk regression and restricted cubic spline modeling in the 4D Study cohort and validated in a separate cohort of 104 US patients on dialysis after a median follow-up of 2.5 years.

Results
A total of 1108 patients had baseline oxalate measurements, with a median oxalate concentration of 42.4 µM. During follow-up, 548 patients died, including 139 (25.4%) from sudden cardiac death. A total of 413 patients reached the primary composite cardiovascular end point (cardiac death, nonfatal myocardial infarction, and fatal or nonfatal stroke). Patients in the highest oxalate quartile (≥59.7 µM) had a 40% increased risk for cardiovascular events (adjusted hazard ratio [aHR], 1.40; 95% confidence interval [95% CI], 1.08 to 1.81) and a 62% increased risk of sudden cardiac death (aHR, 1.62; 95% CI, 1.03 to 2.56), compared with those in the lowest quartile (≤29.6 µM). The associations remained when accounting for competing risks and with oxalate as a continuous variable.

Conclusions
Elevated serum oxalate is a novel risk factor for cardiovascular events and sudden cardiac death in patients on dialysis. Further studies are warranted to test whether oxalate-lowering strategies improve cardiovascular mortality in patients on dialysis.
Yoga Practitioners Exhibit Higher Parasympathetic Activity and Baroreflex Sensitivity and Better Adaptability to 40 mm Hg Lower-Body Negative Pressure
Authors: Anasuya Boligarla , Deepak K. K. , Jaryal Ashok 
Published: July 2021

Abstract
Yoga has been shown to improve autonomic conditioning in humans, as evidenced by the enhancement of parasym-pathetic activity and baroreflex sensitivity. Therefore, we hypothesized that the experience of yoga may result in adaptation to acute hemodynamic changes. To decipher the long-term effects of yoga on cardiovascular variability, yoga practitioners were compared to yoga-naïve subjects during exposure to –40 mm Hg lower-body negative pressure (LBNP). A comparative study was conducted on 40 yoganaïve subjects and 40 yoga practitioners with an average age of 31.08 ± 7.31 years and 29.93 ± 7.57 years, respectively. Heart rate variability, blood pressure variability, baroreflex sensitivity, and correlation between systolic blood pressure and RR interval were evaluated at rest and during LBNP. In yoga practitioners, the heart rate was lower in supine rest (p = 0.011) and during LBNP (p = 0.043); the pNN50 measure of heart rate variability was higher in supine rest (p = 0.011) and during LBNP (p = 0.034). The yoga practitioners’ standard deviation of successive beat-to-beat blood pressure intervals of systolic blood pressure variability was lower in supine rest (p = 0.034) and during LBNP (p = 0.007), with higher sequence baroreflex sensitivity (p = 0.019) and ~ high-frequency baroreflex sensitivity. Mean systolic blood pressure and RR interval were inversely correlated in the yoga group (r = –0.317, p = 0.049). The yoga practitioners exhibited higher parasympathetic activity and baroreflex sensitivity with lower systolic blood pressure variability, indicating better adaptability to LBNP compared to the yoga-naïve group. Our findings indicate that the yoga module was helpful in conditions of hypovolemia in healthy subjects; it is proposed to be beneficial in clinical conditions associated with sympathetic dominance, impaired barore-flex sensitivity, and orthostatic intolerance.
An Intelligent Path Evaluation Algorithm for Congestion Control in Wireless Sensor Networks
Authors: Dr. Sukhkirandeep Kaur Makul Mahajan, 
Published: July 2021

In Wireless Sensor Networks (WSNs), congestion occurs when the traffic load on the node reaches obvious network channel power and is considered as a prominent problem. So it is highly essential to identify, prevent and fix congestion when taking into account the network’s restricted re- sources. If congestion in the network is not managed correctly, it can lead to significant loss of QoS parameters, such as decreasing network throughput, increasing energy usage, and decreasing the distribution ratio of packets at the destination or sink node. In this article, we have formulated an algorithm to manage congestion using a modified ant colony algorithm that considers the residual energy, buffer occupancy and bandwidth of the neighbour node for selecting the best node to route the traffic that needs strict QoS requirements. For routing the traffic, there may be a variety of neighbour nodes exists in the network ,and if congestion occurs at any selected neighbour node the algorithm will rework to check the quality of rest of the neighbor nodes by calculating a path preference probability metric. The neighbour node with maximum path preference probability will be selected for routing the data packets belonging to real-time traffic that have stringent QoS. The proposed algorithm was simulated and tested using NS 2.33 and it was found that as opposed to the standard AntSense algorithm, the proposed algorithm is capable of achieving lower average energy consumption and packet loss ratio respectively with higher throughput.
Floristic regions of the Samur-Chirakhchay interfluve and Dzhufudag (Southern Dagestan) according to analysis of petrophyte species composition
Authors: Yusufov G. A. , Teymurov A. A. , Soltanmuradova Z. I. , Saypulaeva B. N. , Bortsov K. V. 
Published: July 2021

Aim. To undertake floristic zoning of the Samur-Chirakhchay interfluve and Dzhufudag for the analysis of the species composition of petrophylic complexes.Material and Methods. A list of obligate petrophytes was compiled based on the results of processing the authors' own field collections and taking into account information from floristic reports and determinations. The assessment of similarity of species composition of petrophytes in the regions was carried out using the Jaccard (Kj) and S0rensen-Czekanowski (Ksc) coefficients.Results. A subdivision of the mountain area studied into 7 floristic regions was carried out, based on a comparison of floristic lists and the presence of endemic species.Conclusion. The tendency in petrophytes to isolation of species forms, arising from spatial isolation relating to habitat specificity, makes it possible to quite accurately draw boundaries corresponding to the natural boundaries of differentiation of floras.
<i>Antarctophthirus nevelskoyi</i> n.sp. (Anoplura: Echinophthiriidae) - a new species of parasite of the Northern fur seal (<i>Callorhinus ursinus</i> L., 1758) at Tyuleniy Island, Okhotsk Sea, Russia
Authors: Shchelkanov M. Yu. , Shchelkanov E. M. , Moskvina T. V. 
Published: July 2021

Aim.To perform a morphological study of seal lice (Anoplura: Echinophthiriidae) of the genus Antarctophthirus Enderlein, 1906 taken from Northern fur seals (Callorhinus ursinus L., 1758) at Tyuleniy Island, Okhotsk Sea, Russia).Material and Methods. Seal lice were collected from the nasal passages of Northern fur seal C. ursinus pups during a scheduled ecological and virological expedition to Tyuleniy Island in August 2017. Fourteen samples of seal lice (11 imago males, 1 imago female, 1 nymph of the 2nd age, 1 nymph of the 3-rd age) were stored in 70% ethanol at room temperature from the time of collection until the start of the study. Morphological features of the insects were studied using light and scanning electron microscopy and compared with the available data in the scientific literature.Results.Unique patterns of the arrangement of spines were found in the examined samples that is a sufficient species feature for representatives of this family and allows the identification of a new species of seal lice.Conclusion.A new species of seal lice, Antarctophthirus nevelskoyi n.sp., was identified and described and named after the famous Russian explorer of the Far East, Admiral Gennady Ivanovich Nevelskoy (18131876).
Polymorphism of genes CAST, GH, GDF9 of sheep of the Dagestan mountain breed
Authors: Ozdemirov A. A. , Chizhova L. N. , Khozhokov A. A. , Surzhikova E. S. , Dogeev G. D. , Abdulmagomedov S. Sh. 
Published: July 2021

Aim. To study the polymorphism of the genes calpastatin (CAST), somatotropin (GH) and differential growth factor (GDF9) of sheep of the Dagestan mountain breed.Material and Methods. Studies on the genetic typing of Dagestan mountain sheep according to CAST, GH and GDF9 genes were carried out in conditions of distant pasture farming in the Republic of Dagestan by the Genetics and Breeding Laboratory of the Federal Agrarian Scientific Centre of the Republic of Dagestan, an accredited laboratory of immunogenetics and DNA technologies of the All-Russian Research Institute of Sheep and Goat Breeding and a branch of the North Caucasus Federal Scientific Agrarian Centre. These investigations were undertaken by the PCR-RFLP method (polymyrase chain reaction - restriction fragment length polymorphism) on a Tersik four-channel programmable thermal cycler from DNA-Technologia (Russia) using specific primers synthesized in the SYNTHOL research and production laboratory (Moscow).Results. Carrying out PCR-RFLP revealed breed-specific alleles with different frequency of occurrence, which was: in the locus of the CAST gene - allele CASTN - 0.03; allele CASTM - 0.97; at the GH gene locus - GHA allele - 100.0, GHB allele - 0; in the locus of the GDF9 gene - the GDF9A allele - 0.25, the GDF9G allele - 0.75, which determined the frequency of occurrence of the homo- and heterozygous genotypes: CASTNN, CASTMM and CASTNM - 93.0; 0 and 7.0%; GHAA, GHBB and GHAB - 100.0 and 0%; GDF9AA, GDF9GG and GDF9АG- 16.0, 66.0 and 19.0%, respectively.Conclusion. The regularity revealed can be considered as an ecological factor that optimizes the adaptive functions of the sheep's organism, on the one hand, an evolutionary selection process that contributes to the creation of a specific way of genetic structures in the population, on the other. The assumption is made that the information obtained can serve as the beginning of a more in-depth study of the unique gene pool of sheep of the Dagestan rock breed for its further improvement. Variants of genetic marker profiles of parental pairs are proposed for accumulation in breeding herds bred in different ecological-geographical zones and genotypes of carriers of selection-significant genetic structures.
Interrelation of climatic factors of soil formation with the formation of chemical and physical-chemical properties of soil cover in agricultural landscapes of the Central Chernozem Region of Russia
Authors: Chuyan O. G. , Karaulova L. N. 
Published: July 2021

Aim. To assess the interrelations of chemical and physical-chemical parameters of soil cover properties with climatic factors of soil formation in agricultural landscapes of the Central Chernozem Region (CCR) of Russia.Materials and Methods. The research was carried out using a systemic analysis of the complex of agroclimatic and soil parameters. Soil properties were assessed by the weighted average characteristics of arable soils for the areas of the Central Chernozem Region. Hydrothermal conditions were taken into account by rainfall, temperature and the amount of active temperatures for the period 1960-2000.Results. Estimated excess of annual precipitation (440-640 mm) over evaporation (407-500 mm) in the average annual cycle ensures the formation of total runoff and soil washability in the amount of 40-150 and 17-104 mm. This determines soil acidity (pHKCL, R2 = 0.36...0.73). Optimal conditions of humus accumulation are formed when the humidity factor is 0.8-0.9. Mesorelief is a factor of spatial heterogeneity of the total soil composition with which 85% of physical-chemical properties and up to 70% of nutrient availability are associated.Conclusion. The differences in the hydration of the territories both at the scale of the CCR and local levels determine the intensity of geochemical runoff, the oxidation-reduction regime and total chemical soil composition which constitute the basis of heterogeneity in the content of organic matter, acidic-base and other properties.
Evaluation of the trophic level and self-cleaning ability of small flows by hydrochemical indicators (through the example of the Rpen River)
Authors: Trifonova T. A. , Chesnokova S. M. , Savelev O. V. 
Published: July 2021

Aim. Assessment by nitrification index values of the level of trophicity and toxicity for aquatic organisms in the waters of a small watercourse in an urbanized area by the content of nutrients in the water and its selfcleaning ability.Materials and Methods. The concentration of compounds of nutrients in the waters of the river was determined using the "Kapel 104T." system of capillary electrophoresis. Water was sampled for analysis according to GOST R 51592- 2000. The water content of readily oxidized organic compounds was assessed by the magnitude of permanganate oxidizability (PND F 14.1; 2.4.154-99) and difficultly oxidized compounds by the magnitude of the chemical oxygen consumption (RD 52.24.421-2012). Assessment of the water trophic level was evaluated by measuring the content of various forms of mineral nitrogen and mineral phosphorus. The aggregation index characterizing the toxicity of various forms of mineral nitrogen to aquatic organisms was calculated by their ratio to MPC for fishery reservoirs. The nitrifying ability of river waters was estimated by the value of the nitrification index (Initr.), calculated by the ratio of the concentration of nitrogen of nitrates in water to the sum of the concentrations of various forms of mineral nitrogen and the self-cleaning ability by the values of the nitrification index.Results. In terms of the aggregation index, water at all sampling points was found to be toxic. The river ecosystem is characterized by a weak ability to cleanse itself and a weak nitrifying ability, which is associated with the influence of numerous cyanotoxins on the microbiocenosis of the watercourse and filtration organisms.Conclusion. It was shown that the most sensitive indicator of trophicity of river waters is the concentration of the mineral phosphorus. Through measuring the ratio of the concentrations of mineral nitrogen to mineral phosphorus, it was established that blue-green algae (cyanobacteria), producers of cyanotoxins, dominate in the phytoplankton of the river in all the points studied.
Contemporary ecological state of waters of the Caspian Sea during development of oil and gas deposits
Authors: Sokolskiy A. F. , Kanbetov A. Sh. , Popov N. N. , Mutashev B. A. , Rabazanov N. I. 
Published: July 2021

Aim. This study was an attempt by the authors to identify the impact of oil production in the Caspian Sea on the quality of waters surrounding oil and gas-production platforms.Material and Methods. In 2018, by order of the Committee for Forestry and Wildlife of the Ministry of Agriculture of the Republic of Kazakhstan, Kazekoproekt carried out comprehensive marine research to assess the state of biological resources in the eastern part of the Caspian Sea. All studies were carried out according to standard methods accepted in international practice. Samples were collected in summer (July-August) 2018 and autumn (September) 2018.Results. An analysis of the materials of environmental studies carried out in the water area of the eastern part of the Caspian Sea in 2018 established the absence of biogenic concentrations in sea water in excess of the standard indicators. It was found that in the waters surrounding several stations in summer and autumn, concentrations of oil products were exceeded. The concentrations of pesticides in the waters of the northern Caspian Sea recorded in 2018 were not detected.Conclusion. It was found that in the eastern part of the Caspian Sea in 2018 there was no concentration of biogenic elements in sea water above the standard indicators. Of the heavy metals, an excess of maximum permissible concentrations was found only at one station - of copper in the summer over 159 sq. m and in the autumn over 121 sq. m. Of particular concern is the fact that at several stations in summer and autumn excessive concentrations of petroleum products were recorded. The concentrations of pesticides in the waters of the northern Caspian Sea recorded in 2018 were not detected.
Epilepsy and COVID-19: predictors of a positive outcome in patients with epilepsy (based on analysis of clinical cases)
Authors: Odintsova G. V. , Bannikova V. D. 
Published: July 2021

Background. Many patients with neurological disorders have an increased risk of infection and the severe course of COVID-19. Studies on positive predictors of seizure outcomes with the 2019 novel coronavirus disease remain limited.The objective is to study predictors for positive health outcomes after COVID infection in patients with epilepsy based on analysis of clinical observations.Design and Methods. Study design - the work is a part of a prospective observational study of seizure dynamics after COVID infection in patients with epilepsy.Results. The presented clinical observation demonstrates a positive health outcome after COVID infection in a young patient with the genetic generalized epilepsy with sustained clinical and electroencephalographic seizure remission on the next generation AED monotherapy (brivaracetam).Conclusion. Predictors for positive health outcome after the 2019 novel coronavirus disease in patients with epilepsy include a young age, absence of somatic comorbidities, seizure remission, modern drug use with no interaction among AEDs and antibiotics and antivirals for the coronavirus disease treatment. Despite the encouraging data on the favourable course of epilepsy in cases of developing COVID-19, further research is needed to continue.
ZDRAVOTNÁ VÝCHOVA A STAROSTLIVOSŤ O ZDRAVIE VOJVODINSKÝCH SLOVÁKOV NA ROZHRANÍ 19. A 20. STOROČIA (na príklade ľudovej školy v Kysáči)
Authors: Uhlarik Jasna S 
Published: July 2021

Verejná zdravotná starostlivosť sa v Uhorsku dostala do záujmovej sféry štátu a súčasne sa začala intenzívne rozvíjať v období osvietenstva. Jednou z najdôležitejších úloh štátu (na čele ktorého bola Mária Terézia v čase najintenzívnejšieho sťahovania Slovákov na Dolnú zem) bolo chrániť obyvateľstvo pred často sa šíriacimi nákazlivými chorobami. Školy boli inštitúcie, prostredníctvom ktorých sa najrýchlejšie mohli uskutočňovať tieto výchovno-vzdelávacie intencie osvietenských panovníkov a cez tlačené médiá, hlavne katechizmy o zdraví a školské učebnice, preniknúť medzi všetky (gramotné) vrstvy obyvateľstva. Cieľom tohto výskumu bolo zistiť úroveň zdravotnej výchovy a starostlivosti, ako i hygienické podmienky a zdravotné opatrenia v každodennom živote konkrétnej slovenskej dolnozemskej ľudovej školy v Kysáči na rozhraní 19. a 20. storočia prostredníctvom Zápisnice zasadnutí školskej stolice cirkvi evanj. a. v. Kysácskej od r. 1895. Skúmaním obsahovej náplne učebníc, ktoré sa používali v ľudovej škole v Kysáči bolo zistené, aké vedomosti z oblasti zdravovedy boli žiakom dostupné a tiež aj aké informácie o zdravotnej starostlivosti mohli sprostredkovať učitelia z dostupnej odbornej literatúry. Na doplnenie informácií sú použité školské zákony a zákonné zdravotné články a predpisy, učiteľské príručky, ako i pedagogické časopisy tej doby.
Evaluación inicial del Sistema de Referencia y Contrarreferencia ambulatoria en la DIRIS Lima Norte, desde los centros materno infantiles
Authors: Llanos Zavalaga Luis Fernando , Orellana Vásquez Alberth Teófilo , Aguado Taquire Henry Francisco 
Published: July 2021

Desde julio 2018 se implementa el SRCR de consulta ambulatoria en IPRESS de DIRIS Lima-Norte utilizando el aplicativo REFCON; incluye cinco sub-procesos, tres de ellos ocurren en IPRESS de destino. Objetivo: Caracterizar las referencias emitidas en las IPRESS I-4 que tuvieron como IPRESS de destino a los hospitales de la DIRIS Lima Norte, y el tiempo de citas de las mismas. Material y métodos: Estudio cuantitativo observacional de tipo transversal, que incluyó las referencias emitidas en el periodo mayo-octubre 2019, por siete IPRESS I-4. Se analizaron las referencias por IPRESS, sexo, etapa de vida, especialidad y tiempos hasta la cita. Se estimó medidas de tendencia central y dispersión; y chi-cuadrado para el análisis bivariado, usando Stata v.16. Resultados: Hubo 19 951 referencias de siete IPRESS de origen. La población más referida fue de 30-59 años (39,22%) y mujeres (67,04%). Se excluyó del análisis de tiempos 2 714 referencias por información incompleta. El tiempo de aceptación en IPRESS de destino mostró gran variabilidad, solo 23,14% fueron aceptadas en menos de 24 horas. El subproceso de aceptación hasta la cita mostró que la mitad de pacientes demoraron entre 80-85 días en ser atendidos. Solo se reportaron 110 contrarreferencias; de ellas, 48 (43,6%) fueron a Juan Pablo II. Conclusiones: Se evidencia una incipiente implementación, ausencia de normatividad, irregular capacitación de personal y limitación de personal que se traduce en alto porcentaje de rechazos y retrasos en aprobación de referencias. Y tiempos mayores de 80 días desde el registro de la referencia hasta la cita, para el 50% de las mismas, desconociendo el porcentaje de citas atendidas.