bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibacterial Activity of The Iron-Zinc Oxide Nanoparticles Synthesized Via Electric Discharge Method
Authors: Shahbazi Fereshteh , Ahmadi Reza , Noghani Mohammad , Karimi Gholamreza 
Published: October 2021

Abstract
With the increase in diseases caused by bacterial and viral infections, the need for antibiotics has increased. On the other hand, by creating drug resistance to organicmoietiesbased antibiotics, novel antibiotics have attracted the attention of researchers.Nano-scale metal oxides are increasingly being considered for medical applications, especially as antibacterial agents.In this study, iron oxide nanoparticles (IONPs) and zinc oxide nanoparticles (ZONPs) were prepared via electrical discharge method in liquid medium by changing parameters such as wire diameter and electric current intensity. Synthesized NPs were evaluated by XRD, UV_Visible, FE_SEM, EDS, HR_TEM and TEM analyzes. Also, the antibacterial properties of these nanoparticles were evaluated in different ways against gram-positive and gram-negative bacteria.
Soil N2O and CH4 Emissions From Fodder Maize Production With and Without Riparian Buffer Strips of Differing Vegetation
Authors: Dlamini Jerry , Cardenas Laura , Tesfamariam Eyob , Dunn Robert , Evans Jess , Hawkins Jane , Blackwell Martin , Collins Adrian 
Published: October 2021

Abstract
Purpose: Nitrous oxide (N2O) and methane (CH4) are some of the most important greenhouse gases of the 21st century. Vegetated riparian buffers are primarily implemented for their water quality functions in agroecosystems and their location in the agricultural landscape allows them to intercept and process pollutants from immediately adjacent agricultural land. They recycle increase soil carbon (C), intercept nitrogen (N)-rich runoff from adjacent croplands, and are seasonally anoxic, promoting processes producing environmentally harmful gases including N2O and CH4. Against this context, the study quantified these atmospheric losses between a cropland and vegetated riparian buffers that serve it.Methods: We used the static chamber to measure N2O and CH4 emissions simultaneously with soil. Gas measurements were done simulataneously with soil and environmental variables for a 6-month period in a replicated plot-scale facility comprising of maize cropping served by three vegetated riparian buffers, namely: (i) a novel grass riparian buffer; (ii) a willow riparian buffer, and; (iii) a woodland riparian buffer. These buffered treatments were compared with a no-buffer control. Results: The no-buffer control generated the largest cumulative N2O emissions of 18 929 g ha-1 (95% confidence intervals: 524.1 - 63 643) whilst the maize crop upslope generated the largest cumulative CH4 emissions of 5 050 ± 875 g ha-1. Soil N2O and CH4-based global warming potential (GWP) were lower in the willow (1223.5 ± 362.0 and 134.7 ± 74.0 kg CO2-eq. ha-1 year-1, respectively) and woodland (1771.3 ± 800.5 and 3.4 ± 35.9 kg CO2-eq. ha-1 year-1, respectively) riparian buffers.. Conclusions: Our results suggest that maize production in general, and situations where such cropping is not undertaken in tandem with a riparian buffer strip, result in atmospheric CH4 and N2O concerns.
Autoantibodies neutralizing type I interferons in 20% of COVID-19 deaths in a French hospital
Authors: CHAUVINEAU-GRENIER Angelique , BASTARD Paul , SERVAJEAN Antoine , GERVAIS Adrian , ROSAIN Jeremie , JOUANGUY Emmanuelle , COBAT Aurelie , CASANOVA Jean-Laurent , ROSSI Benjamin 
Published: October 2021

Abstract
Recent studies reported the presence of pre-existing autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) in at least 15% of patients with critical or severe COVID-19 pneumonia. In one study, these auto-Abs were found in almost 20% of deceased patients across all ages. We aimed to assess the prevalence and clinical impact of the auto-Abs to type I IFNs in Seine-Saint-Denis district, which was one of the most affected areas by COVID-19 in France during the first wave. We tested for the presence of auto-Abs neutralizing type I IFNs in a cohort of patients admitted for critical COVID-19 pneumonia during the first wave in the spring of 2020 in medicine departments at Robert Ballanger Hospital, Aulnay sous Bois. We found circulating auto-Abs that neutralized 100 pg/mL IFN-α2 and/or IFN-ω in plasma 1/10 in 7.9% (11 of 139) of patients hospitalized for critical COVID-19. The presence of neutralizing auto-Abs was associated with an increased risk of mortality as these auto-Abs were detected in 21% of patients who died from COVID-19 pneumonia. Deceased patients with and without auto-Abs did not present overt clinical differences. These results confirm both the importance of IFN-I immunity in host defense against SARS-CoV-2 infection and the usefulness of detection of auto-Abs neutralizing type I IFNs in the management of patients.
Tools for Early Screening of Autism Spectrum Disorders in Primary Health Care – A Scoping Review
Authors: Sobieski Mateusz , Korzeniewska Aleksandra , Sekułowicz Małgorzata , Bujnowska-Fedak Maria Magdalena 
Published: October 2021

Abstract
Background. Autism spectrum disorder (ASD) is a neurodevelopmental disorder that manifests itself in early childhood. Early diagnosis of these disorders allows for the initiation of early therapy, which is crucial for the child's further functioning in society. Objectives. This review aims to gather and present the existing ASD screening tools used in primary care and adapted to different countries conditions linguistically and culturally.Eligibility criteria. We searched for English-language publications on ASD screening tools for children aged 0-3 years suitable for use in primary care (i.e. free, requiring no additional training or qualifications).Sources of evidence. Four databases were explored to find English studies on ASD screening tools intended for the rapid assessment of children aged 0–3.Charting methods. The information sought (specific features of the questionnaires relevant to primary health care workers, psychometric and diagnostic values of a given cultural adaptation of screening tools, and the linguistic and cultural changes made) were extracted and collected to create profiles of these tools.Results. We found 81 studies which met inclusion criteria and underwent full data extraction. Three additional data sources were included. These allowed to create 75 profiles of adaptations for 26 different screening tools and collect data on their psychometric values and characteristic features.Conclusions. The results of our review show that there are several diagnostic tools concordant culturally and linguistically with a given population for early ASD screening in primary care setting. They could be an effective method of accelerating the diagnostic process and starting personalized therapy faster. However, most tools have significant limitations – some are only available for research purposes, while others do not have scientific evidence to prove their effectiveness.
A temperature-regulated circuit for feeding behavior
Authors: Qian Shaowen , Yan Sumei , Pang Ruiqi , Zhang Jing , Liu Kai , Shi Zhiyue , Wang Zhaoqun , Penghui Chen , Zhang Yanjie , Luo Tiantian Luo , Hu Xianli , Xiong Ying , Zhou Yi 
Published: October 2021

Abstract
Both rodents and primates have evolved to orchestrate food intake to maintain thermal homeostasis in coping with ambient temperature challenges. However, the mechanisms underlying temperature-coordinated feeding behavior are rarely reported. Here we found that a non-canonical feeding center, the anteroventral and periventricular portions of medial preoptic area (apMPOA) responded to altered dietary states. Two neighboring but distinct apMPOA neurons mediated feeding in receiving anatomical inputs from external and dorsal subnuclei of lateral parabrachial nucleus (LPB). While both populations are glutamatergic, the arcuate nucleus (ARC)-projecting neurons in apMPOA can sense low temperature and promote food intake. The other type, the paraventricular hypothalamic nucleus (PVH)-projecting neurons in apMPOA are primarily sensitive to high temperature and suppress food intake. Cutting off both pathways can eliminate the temperature-dependence of feeding. Further projection-specific RNA sequencing identified that the two neuronal populations were molecularly marked by galanin receptor and apelin receptor. These findings reveal an unrecognized cell populations and circuits of apMPOA that orchestrates feeding behavior against thermal challenges.
A Novel Feature-Transferred Prediction Network For Remaining Useful Life of Rotating Machinery
Authors: Lin Tianjiao , Wang Huaqing , Song Liuyang , Cui Lingli 
Published: October 2021

Abstract
With the increasing complexity of CNC machine tools and other rotating machinery, it becomes more and more important to improve the reliability of such machines. It is necessary to estimate the remaining Useful Life (RUL) of the important parts such as bearings of these devices. However, the operating conditions of such parts are often very complicated, and there is a great difference between different devices. Therefore, it is difficult to use the traditional mechanism analysis method, which is not only very hard, but also generally has low prediction accuracy. In order to solve the above problems, this paper proposes a Feature-transferred Prediction Network (FTPN), which can adapt to various working conditions, combining with the neural network method in the field of artificial intelligence, and effectively realizes RUL prediction. Since the existing neural network methods were originally proposed to solve the problems in other fields, such as semantic recognition, this paper uses the feature transfer method to improve them. Firstly, the source network based on Convolutional Neural Network (CNN) is pre-trained for fault recognition, and the fault feature information extracted after training is stored in the fault feature layer. Second, CNN and Gate Recurrent Unit (GRU) are used to build target networks and fit the relationship between time series and remaining longevity. Finally, a special loss function is designed to transfer the features extracted from the source network to the target network to help the target network learn fault features and better predict the mechanical RUL. In order to verify the effectiveness of the proposed method, experiments are carried out using the public data set of accelerated life of bearings, and high prediction accuracy is obtained, which proves that the proposed method has certain generalization. The comparison with the existing methods on the same data set shows that the proposed method has a broad industrial application prospect.
Development and Feasibility Testing of a Physical Activity Intervention For Youth With Anxiety and Depression: a Study Protocol
Authors: Kodal Arne , Reilly John J. , Muirhead Fiona , Wergeland Gro Janne H. , Thorsen Paul Joachim Bloch , Bovim Lars Peder , Elgen Irene Bircow 
Published: October 2021

Abstract
Background: Anxiety and depressive disorders in children and adolescents are highly prevalent and account for more than half of all youth psychiatric disorders. Left untreated, anxiety and depression leads to numerous detrimental outcomes, including reduced quality of life, psychiatric and somatic comorbidity and even reduced lifespan. This puts a large strain on child and adolescent mental healthcare services (CAMHS) to provide effective treatments. However, even when provided the best evidence based treatment, between 40-50 % continue to report significant symptom burdens. Thus, there is an immediate need for supplemental and/or new treatment approaches. Physical activity as a supplementary treatment may be such an approach. However, research investigating this approach within this population is scant. This protocol paper describes the development and feasibility trial of a physical activity based intervention targeting anxiety and depressive symptoms in youth treated in CAMHS.Methods/design: The study is based on the UK Medical Council Research Framework (MRC) for developing and evaluating complex interventions. Feasibility and acceptability of the physical activity intervention (Confident, Active and Happy Youth) will be evaluated in an uncontrolled open-label trial using qualitative and quantitative data. Twenty youths with anxiety and/or depressive symptoms will be recruited. Acceptability of assessment procedures, the intervention, and perceived benefits and barriers to participation will be assessed, and qualitative interviews with participants, caregivers and referring specialists will explore contextual and practical factors associated with intervention delivery. Physical activity will be measured using the Actigraph GT3X+ monitor at baseline and post-intervention and change in anxiety and depression will be assessed. Discussion: This study will contribute to the development of supplementary physical treatment interventions for youth with anxiety and depression in contact with CAMHS. The goal is to examine new avenues of treatment that ultimately may improve upon current treatment outcomes of anxiety and depression. This work will be in preparation for a future definitive RCT of this approach, in line with the MRC framework.Trial registration: ClnicalTrials.gov, NCT05049759. Registered 19 August 2021 - Retrospectively registered.
Relationship Between Arteriosclerosis and Body Composition in Patients with type 2 Diabetes Mellitus: Cross-Sectional Study
Authors: Furuya Tomoki , Tamura Yuma , Tamiya Hajime , Tsurumi Tomoki , Ogawa Susumu , Kitahama Shinji , Motoyama Takeshi , Nakatani Yuki , Yasu Takanori 
Published: October 2021

Abstract
BackgroundReduced lower limb circumference due to sarcopenia in patients with type 2 diabetes mellitus (T2DM) could be a useful screening tool for arteriosclerosis. Hence, the objective of this study was to clarify the relation between lower limb circumference and other body composition factors, muscle strength, and patient characteristics,and the progression of arteriosclerosis in patients with T2DM. MethodsWe included114 patients with T2DM receiving outpatient care, and assessed body composition (lower limb circumferences including tibial rough surface-calf 26% [TRSC%]), muscle strength indicators, patient characteristics, clinical diabetic neuropathy status, and examined their associations with brachial–ankle pulse wave velocity (ba-PWV) using multiple regression analysis. Additionally, the severity of ba-PWV was classified into 1400 cm/s, 1650 cm/s, and 1963 cm/s to investigate their associations using logistic regression analysis. ResultsThe mean age was 63.12±11.96 years and participants had T2DM for 11.25±9.45 years. Body mass index (BMI), HbA1c, abnormal ankle reflex, and TRSC% were adopted in the multiple regression analysis with ba-PWV as the dependent variable. In the logistic regression analysis of ba-PWV divided by 1400 cm/s, an index of arteriosclerosis, BMI was adopted, and when divided by 1963 cm/s, a mortality risk index, BMI, abnormal ankle reflex, and TRSC% were adopted.ConclusionArteriosclerosis in patients with T2DM is associated with a decrease in lower limb circumference; TRSC% was independently associated with severe arteriosclerosis when ba-PWV was ≥1963 cm/s, which is an indicator of mortality risk. Thus, lower limb circumference in the form of TRSC% may reflect the progression of arteriosclerosis.
Low-Dose Ranıbızumab Admınıstratıon in Retınopathy of Prematurıty
Authors: Tök Levent , Seyrek Lütfi , Tök Özlem 
Published: October 2021

Abstract
Purpose: To evaluate the efficiency of low dose intravitreal ranibizumab therapy in the treatment of aggressive posterior premature retinopathy (APROP).Methods: A total of 124 eyes of 62 patients who underwent intravitreal ranibizumab with APROP diagnosis between January 2015-January 2021 were evaluated retrospectively. After receiving family-approved informed consent, low-dose intravitreal ranibizumab was administered and regular follow-ups were performed.Results: Patients included in the study had a mean birth week of 26.6 (23-33 weeks), a mean birth weight of 905 (450-1970) grams, an average injection week post-natal 9.1 (4-19) weeks. The mean follow-up period was 63 (24-250) weeks. In all eyes, it was observed that ROP was regressed in the first week control after injection and no asymmetrical response was observed in the eyes of any baby. A 58 eyes recovered with a single dose of intravitreal injection therapy and peripheral retinal vascularization was completed. A second injection was required in 38 eyes. Rescue treatment was applied in addition to intravitreal ranibizumab treatment in 22 eyes of 11 babies. None of the patients had any ocular or systemic side effects.Conclusıon: Low-dose intravitreal ranibizumab injection with close follow-up and appropriate timing is an effective treatment modality in APROP. Even in patients undergoing rescue laser treatment, the treatment can be completed with a wider visual field.
Images Classification of Gurumukhi Month’s Name Images using Various Convolutional Neural Network Optimizers
Authors: Singh Tajinder Pal , Gupta Sheifali , Garg Meenu , Koundal Deepika , Zaguia Atef 
Published: October 2021

Abstract
The Gurumukhi script has a complex structure for which text recognition based on an analytical approach can misinterpret the script. For error-free results in text recognition, the author has proposed a holistic approach based on classification of Gurumukhi month’s name images. For this, a new convolutional neural model has been developed for automatic feature extraction from Gurumukhi text images. The proposed convolutional neural network is designed with five convolutional, three polling layers, one flatten layer and one dense layer. To validate the results of the proposed model, the dataset was self-created from 500 distinct writers. The performance of the model has been analyzed with 100 epochs, 40 batch sizes and different optimizers. The various optimizers that have been used for this experimentation are SGD, Adagrad, Adadelta, RMSprop, Adam, and Nadam. The experimental results show that the proposed CNN model performed best with Adam optimizer in terms of accuracy, computational time, F1 score, precision and recall.
Selenium Supplementation Influences Mice Testicular Selenoproteins Driven By Gut Microbiota
Authors: Ramírez-Acosta Sara , Selma-Royo Marta , Collado M Carmen , Navarro Francisco , Abril Nieves , Barrera Tamara García 
Published: October 2021

Abstract
Selenium is a well-known essential element with important roles in human reproductive health mainly due to its antioxidant character. This study aimed to investigate the potential role of selenoproteins on the gut microbiota-reproductive health. A new assay for the absolute quantification of selenoproteins in testicular tissue based on two dimensional chromatography with inductively coupled plasma mass spectrometry was performed for the first time. Gut microbiota profile was obtained by 16S rRNA gene sequencing. Numerous associations were found between testicular selenoproteins and gut microbiota (e.g. Mucispirillum, related with sperm activity and testosterone, was associated to glutathione peroxidase (GPx) and selenoalbumin (SeAlb), while Escherichia/Shigella, related to sex hormones, correlated with GPx, selenoprotein P (SelP) and SeAlb). The effects of Se-supplementation on testicular selenoproteins only occurs in conventional mice, suggesting a potential selenoproteins-microbiota interplay that underlies in testicular function. The selenoproteins GPx and SelP have been quantified for the first time in testicles, including the novel identification of SeAlb, a protein with nonspecifically incorporated Se. These findings demonstrates the significant impact of Se-supplementation on gut microbiota and reproductive health. In addition, the analytical methodology applied for selenoproteins quantification in testicular tissue opens new possibilities to evaluate their role on the gut microbiota-reproductive health axis.
miRNA-3651: a Diagnostic Marker in Oral Squamous Cell Carcinoma?
Authors: Saeidmohamadi Farzane , ghorbanpour Maedeh , Jolehar Maryam 
Published: October 2021

Abstract
Background and aim: microRNAs are a group of small non-coding single-stranded RNAs that control post-transcriptional gene expression. They can act as oncogenes or tumor suppressors by amplifying or preventing the expression of certain genes. present study was conducted to assess the expression of miRNA-3651 in paraffin blocks of oral squamous cell carcinoma (OSCC) cells using qRT-PCR method in Islamic Azad university, dental branch of Tehran in 1399.Material and methods: This case-control study was conducted on 20 paraffin blocks of irritation fibroma (IF) as control group and 20 paraffin blocks of patients with oral squamous cell carcinoma as case group. After RNA extraction, qRT-PCR was performed. all experiments were repeated 3 times for each sample. Eventually the data were analyzed by SPSS 24 statistics software. Differences in miRNA expression levels between the two groups were compared using the independent samples t-test. In order to evaluate the correlation between mean levels of miRNA-3651 marker and different variables (grade, age and sex of patients), Kruskal-Wallis test, Pearson's correlation coefficient test and independent samples t-test were used, respectively.Results: The results showed that the mean expression of this biomarker method was 10.15± 5.44 rpm in normal tissue and 8.11± 1.57 rpm in cancerous tissue. Despite the lower expression of miRNA-3651 in cancerous tissue samples than normal samples, this decrease was not statistically significant (P> 0.05). There was no significant difference between the mean level of miRNA-3651 marker and different grades, age and sex of patients (p> 0.05).Conclusion: In the end, it seems that the evaluation of changes in the expression of miRNAs such as miRNA-3651, can be a minimally invasive method, in early detection and screening of patients with OSCC. Decreased expression of miRNA-3651 marker in cancerous tissue compared to normal tissue indicates the importance of these biomarkers, including miRNA-3651 in the diagnosis of oral cancer, and the researchers of this project suggest further and broader investigations on the mechanism of action and signaling cascades associated with this marker in oral cancer.