bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pendekatan Cooperative Learning Tipe STAD: Peningkatkan Keterampilan Membuat Bantal Karakter Pada Anak Tunagrahita Ringan
Authors: Saputri Popi , Irdamurni  
Published: February 2021

This research is based on the problems that researchers found in the class X/C tunagrahita ringan in SLB N 1 Pariaman in October 2019. Learning skill of making character pillow in children with tunagrahita ringan, the ability of children in practicing activities to make character pillow is still not good and not correct, and have not estabilished a good cooperation in the process of making. The purpose of this research are to prove whether cooperative learning approach of STAD type can improve the skill of making character pillow in tunagrahita ringan children, and describe the learning process in improving the skill of making batako through cooperative learning approach STAD class X at SLB N 1 Pariaman.The type of research used is classroom action research, conducted in the form of collaboration with classroom teachers. As a research subjects were three children with tunagrahita ringan grade X/C and one classroom teacher. The result obtained through observation, and tests deeds. Then analyzed with qualitatively and quantitatively methods. The results of research after being given tratment for eight times showed that the initial ability before the treatment of making by DW 43%,YD 34%, LT 31% and SR 41%.While at the end of the cycle I the ability of DW increased (49%), YD (37%),LT (35%) and SR (45%).In cycle II the ability of DW increased to (87%), YD (74%) , LT (72%) and SR (86%).
A Safety Study for Long-Time Use of a Novel Pain Management Device, AT-04
Authors: Uchida Takahiro , Tsuchiya Akio , Mitsutake Kazunori , Kishita Kaori , Takaki Kaori , Guto In , Kishita Iwao , Oka Hiroshi 
Published: February 2021

Abstract
Fibromyalgia is a common chronic pain disorder characterized by widespread pain and tenderness in mostly tendon attachments with unknown etiology. Treatment of fibromyalgia is mainly drug and other treatments, especially cognitive behavioral therapy and exercise therapy combined. However, drugs for fibromyalgia have, in general, broad adverse effects. Thus, an unmet medical need remains for effective therapeutic modalities for fibromyalgia. We have recently developed a new magnetic medical device (project code “AT”) that has alternating magnetic fields and stimulates the affected area for pain relief. In the pilot study, AT treatment (twice daily for 10 min) tended to reduce the mean NRS (Numerical Rating Scale) pain score. Moreover, we demonstrated long treatment (30 min) suppressed LPS-induced (Lipopolysaccharide-induced) mRNA IL-6 expression compared with 10-min treatment in vitro. These results assumed that long treatment has high efficiency. To evaluate the safety of long time (120 min/day) AT treatment for 12 weeks. Single center, prospective, open-label, single-arm, intervention study to demonstrate the safety of long-time use of AT in 5 healthy Japanese volunteers to 12 weeks. During the intervention period, all of the adverse events were measured. The represents of AT treatment was 99.8 % in 5 subjects. The average and median exposure time of the study device was 135 min per day and 132 min per day, respectively. There were 3 nonserious adverse events and no serious adverse events during this study. This study tested long-time use of AT among 5 healthy subjects in Japan and showed that it did not pose any significant safety concerns. Because there are in-house in vitro data suggesting that the longer exposure of AT achieves a greater effect, the result of this study may allow us to conduct further studies to confirm more effectiveness and safety of long-time use of AT in a larger scale of clinical trial.
Experience of Chest Dysphoria and Masculinizing Chest Surgery in Transmasculine Youth
Authors: Mehringer Jamie E. , Harrison Jacqueline B. , Quain Kit M. , Shea Judy A. , Hawkins Linda A. , Dowshen Nadia L. 
Published: February 2021

OBJECTIVES:
Transmasculine individuals, those assigned female sex at birth but who identify as masculine, have high rates of suicidal behavior and often suffer from chest dysphoria (discomfort and distress from unwanted breast development). Growing numbers of transmasculine youth are pursuing definitive treatment with masculinizing chest surgery (MCS), and adult studies reveal marked benefits of MCS, although little is known about the impact of chest dysphoria on transmasculine youth or the optimal timing of MCS. In this study, we aimed to explore youth experiences of chest dysphoria and the impact of MCS.

METHODS:
Transmasculine youth aged 13 to 21 were recruited from a pediatric hospital–based gender clinic. Participants completed a semistructured qualitative interview exploring the experience of chest dysphoria and thoughts about or experiences with MCS. Interview transcripts were coded by 3 investigators employing modified grounded theory, with the median interrater reliability at κ = 0.92.

RESULTS:
Subjects (N = 30) were a mean age of 17.5 years, and 47% had undergone MCS. Youth reported that chest dysphoria triggered strong negative emotions and suicidal ideation, caused a myriad of functional limitations, and was inadequately relieved by testosterone therapy alone. All post-MCS youth reported near or total resolution of chest dysphoria, lack of regret, and improved quality of life and functioning.

CONCLUSIONS:
We observed consensus that chest dysphoria is a major source of distress and can be functionally disabling to transmasculine youth. MCS performed during adolescence, including before age 18, can alleviate suffering and improve functioning. Additional research is needed to develop patient-reported outcome measures to assess the impact of chest dysphoria and MCS.
Symptomatic SARS-CoV-2 Transmission in Youth and Staff Attending Day Camps
Authors: D'Agostino Emily M. , Armstrong Sarah C. , Humphreys Lisa , Coffman Stacey , Sinclair Gordon , Permar Sallie R. , Akinboyo Ibukunoluwa C. 
Published: February 2021

BACKGROUND AND OBJECTIVES:
As schools reopen nationwide, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in youth settings remains a concern. Here, we describe transmission of SARS-CoV-2 among &gt;6800 youth and staff at YMCA of the Triangle day camps in North Carolina (March to August 2020).

METHODS:
We performed a retrospective analysis of deidentified SARS-CoV-2 cases reported by YMCA day camps in 6 counties (Chatham, Durham, Johnston, Lee, Orange, Wake) over 147 days. Inclusion criteria were youth and staff who enrolled or worked in camps during the study period. Individual-level youth and staff demographics (age, sex, race and ethnicity) were self-reported and linked to SARS-CoV-2 case data by using unique identifiers.

RESULTS:
Youth (n = 5344; 66% white, 54% male, mean age 8.5 years) had a mean camp attendance rate of 88%; staff (n = 1486) were 64% white and 60% female (mean age 22 years). Seventeen primary SARS-CoV-2 infections occurred during the study period among 9 youth (mean age 9.7 years) and 8 staff (mean age 27 years) who were linked to 3030 contacts present in-person during the week before positive cases. Only 2 secondary infections (1 youth and 1 staff) were linked to primary cases. SARS-CoV-2 primary case attack rate was 0.6% (17/3030), and secondary case transmission rate was 0.07% (2/3011).

CONCLUSIONS:
Extremely low youth and staff symptomatic SARS-CoV-2 attack and transmission rates were observed over a 147-day period across 54 YMCA camps from March to August 2020, when local coronavirus disease 2019 prevalence peaked. These findings suggest that the benefit of in-person programming in recreation settings with appropriate mitigation may outweigh the risk of viral transmission.
Velocidad de la marcha y cognición en adultos mayores en atención secundaria de salud
Authors: Lenardt Maria Helena , Setlik Clarice Maria , Pereira Ana Paula , Lourenço Tânia Maria , Marrocos Aristides Barbiero Márcia , Elero Betiolli Susanne , Rodríguez-Martínez María del Carmen 
Published: February 2021

Objetivo: analizar la asociación entre la velocidad de la marcha y la cognición de adultos mayores que se encuentran en asistencia ambulatoria geriátrica y gerontológica.
Materiales y método: estudio cuantitativo transversal realizado con 407 adultos mayores (≥ 60 años) atendidos en el Centro Ambulatorio de Geriatría y Gerontología del municipio de São José dos Pinhais, Paraná (Brasil). La condición de fragilidad física se evaluó utilizando el fenotipo de fragilidad y el cribado cognitivo mediante el Mini-Mental State Examination y el test de fluencia verbal semántica. El análisis univariado se realizó mediante una prueba de chi-cuadrado con nivel de significación estadístico de p ≤ 0,05.
Resultados: del total de participantes, se observaron 226 (55,5 %) adultos mayores prefrágiles, 238 (58,5%) reportaron deterioro cognitivo, 90 (22 %) de la fluidez verbal semántica y 205 (50,4 %) presentaron velocidad de la marcha reducida, variable que registró una asociación significativa con el deterioro cognitivo (p = 0,003) y las alteraciones de la fluencia verbal semántica (p < 0,001).
Conclusiones: los resultados señalan la necesidad de implementar la evaluación de la velocidad de la marcha en adultos mayores como parte de la práctica clínica de geriatría y gerontología. Este componente revela un posible deterioro cognitivo y permite la realización de acciones que puedan perfeccionar el manejo de los cuidados ante la fragilidad física en adultos mayores.
The economic dimension of international students' volunteering – Opportunities for Central Europe
Authors: Dostál Jakub , Kéri Anita 
Published: February 2021

AbstractThere is a growing body of literature that recognizes the importance of volunteering. The economic impact of volunteering has been studied in previous decades, but scientists have not examined that of international students' volunteer activities fully. Therefore, the current paper aims to identify the economic potential of ingoing Erasmus students volunteering in Visegrad 4 countries (Czech Republic, Hungary, Poland, Slovakia). The study uses a quantitative method to investigate Erasmus students' economic potential for volunteering, which is estimated by using two hypothetical situations. First, 90% of the international students shall volunteer for 4 h per month of their stay. Second, only 10% of the international students shall volunteer for 4 h per month. Replacement median wages were used to quantify the economic value of volunteering. This value is represented by an interval estimate with upper and lower bound. Results indicate the importance of international students' volunteer activity, as the potential volunteer hours and their economic value is calculated.
Internationalization in Hungarian higher education. Recent developments and factors of reaching better global visibility
Authors: Lannert Judit , Derényi András 
Published: February 2021

AbstractAuthors present the main results of a research conducted in 2017. Extensive empirical data have been gathered on different issues and dimensions of internationalization among Hungarian universities. Doctoral schools have been covered as well. Data analysis unfolded local and systemic features of internationalization. Hungarian universities are diverse in their development of internationalization. Four development phases of internationalization at institutional level are tackled by mapping internal and external as well as quantitative and qualitative factors. The most advanced universities have reached the point from where a shift could be made from quantitative measures to qualitative ones in order to develop further.
Simultaneous determination of three active flavonoids in rat plasma by HPLC-MS/MS: Application to a comparative pharmacokinetic investigation after oral administration of Schizonepeta tenuifolia aqueous extract with and without its volatile oil
Authors: Liu Siting , Jiang Yulan , Shan Mingqiu , Yu Sheng , Cheng Fangfang , Chen Peidong , Bao Beihua , Cao Yudan , Zhang Li , Wu Qinan 
Published: February 2021

Abstract

Schizonepeta tenuifolia Briq. (ST) has been used as an aromatic exterior-releasing medicine in clinical practice for thousands of years in China. Previous researches have revealed both volatile oil (STVO) and aqueous extract (STAE) from ST showed significant pharmacological activities, such as anti-virus, anti-inflammation, anti-oxidation, and immunoregulation. However, the influence between each other was still unknown. The purpose of this study was to compare the pharmacokinetic profiles of three main flavonoids (luteoloside, apigetrin, and hesperidin) in STAE to illustrate the influence of STVO. A liquid chromatography-tandem mass spectrometry (HPLC-MS) method was established to quantitatively analyze the three absorbed ingredients in the plasma of healthy rats. Biological samples were analyzed on an Agilent Eclipse Plus C18 column (3.0 mm × 150 mm, 3.5 μm) with gradient mobile phase (containing 0.2% formic acid and acetonitrile) at a flow rate of 0.8 mL/min. All the analytes and quercitrin (IS) were investigated with an electrospray ionization source (ESI) using multiple-reaction monitoring (MRM) in negative ionization mode. In addition, this quantitative method showed good linearities (r ≥ 0.9995) and the lower limits of quantification were 0.590–1.19 ng/mL. The intra- and inter-day precisions ranged 3.47–10.45% and 4.29–11.28% for the three analytes. The mean extraction recoveries were in the range of 77.41–109.79% and the average matrix effects were within 83.41–112.67%. The validated method has been fully applied to compare the pharmacokinetic parameters of the three flavonoid glycosides in rat plasma after oral administration of STAE and STAE+STVO. In comparison of luteoloside, apigetrin, and hesperidin in STAE group, it was found that different degree of increasing existed for the time to reach the maximum concentration (T
max), elimination half-life time (T
1/2), the area under the concentration curves (AUC0→t and AUC0→∞) and the maximum concentrations (C
max) in STAE+STVO group. As can be seen from above results, STVO could improve the absorption and bioavailability of the three analytes. These findings would provide some active and strong basis of safe clinical application for ST and further exploitation for STVO from the perspective of drug–drug interaction.
Design of experiments in optimization and validation of hydrophilic interaction liquid chromatography method for determination of amlodipine besylate and its impurities
Authors: Kasagić-Vujanović I. , Knežević D. 
Published: February 2021

Abstract
A new and rapid hydrophilic interaction liquid chromatographic method has been developed for the quantitative analysis of amlodipine besylate and its specific impurities (D, E, and F). For development of this method, a systematic approach which includes Design of Experiments methodology was applied. For the method optimization, Box–Behnken design and specific way Derringer's desirability function were applied. They provided identification of the optimal chromatographic conditions on the basis of obtained mathematical models and graphical procedures (three D graphs). The optimal chromatographic conditions were the analytical column ZORBAX NH2 (250 × 4.6 mm, 5 µm particle size); mobile phase consisted of acetonitrile-water phase (50 mM ammonium acetate, pH adjusted to 4.0 with glacial acetic acid) (90.5:9.5 v/v); column temperature 30 °C, mobile phase flow rate 1 mL min−1, wavelength of detection 230 nm. As other validation parameters were also found to be suitable, the possibility to apply the proposed method for the determination of amlodipine besylate and its impurities in any laboratory under different circumstances has been proven.
Functional assessment of coronary plaques using CT based hemodynamic simulations: Current status, technical principles and clinical value
Authors: Boussoussou Melinda , Vattay Borbála , Szilveszter Bálint , Kolossváry Márton , Simon Judit , Vecsey-Nagy Milán , Merkely Béla , Maurovich-Horvat Pál 
Published: February 2021

AbstractIn recent years, coronary computed tomography angiography (CCTA) has emerged as an accurate and safe non-invasive imaging modality in terms of detecting and excluding coronary artery disease (CAD). In the latest European Society of Cardiology Guidelines CCTA received Class I recommendation for the evaluation of patients with stable chest pain with low to intermediate clinical likelihood of CAD. Despite its high negative predictive value, the diagnostic performance of CCTA is limited by the relatively low specificity, especially in patients with heavily calcified lesions. The discrepancy between the degree of stenosis and ischemia is well established based on both invasive and non-invasive tests. The rapid evolution of computational flow dynamics has allowed the simulation of CCTA derived fractional flow reserve (FFR-CT), which improves specificity by combining anatomic and functional information regarding coronary atherosclerosis. FFR-CT has been extensively validated against invasively measured FFR as the reference standard. Due to recent technological advancements FFR-CT values can also be calculated locally, without offsite processing. Wall shear stress (WSS) and axial plaque stress (APS) are additional key hemodynamic elements of atherosclerotic plaque characteristics, which can also be measured using CCTA images. Current evidence suggests that WSS and APS are important hemodynamic features of adverse coronary plaques. CCTA based hemodynamic calculations could therefore improve prognostication and the management of patients with stable CAD.
Vozes do Leste: os jornalismos literários de Svetlana Aleksiévitch e Hanna Krall
Authors: Passos Mateus Yuri , Breccio Marchetto Arthur 
Published: February 2021

A partir de um close reading de trechos de três obras pretendemos compreender as especificidades do jornalismo literário produzido por mulheres eslavas, a partir do trabalho da bielorussa Svetlana Aleksiévitch e da polonesa Hanna Krall. Buscamos distinguir as particularidades de estilo e voz de cada autora, suas estratégias narrativo-discursivas.
Estimation of Velocity Structures in the Grenoble Basin, France, Using Pseudo Earthquake Horizontal-to-Vertical Spectral Ratio from Microtremors
Authors: Ito Eri , Cornou Cécile , Nagashima Fumiaki , Kawase Hiroshi 
Published: February 2021

ABSTRACTBased on the diffuse field concept for a horizontal-to-vertical spectral ratio of earthquakes (eHVSR), the effectiveness of eHVSRs to invert P- and S-wave velocity structures down to the seismological bedrock (with the S-wave velocity of 3  km/s or higher) has been shown in several published works. An empirical method to correct the difference between eHVSR and a horizontal-to-vertical ratio of microtremors (mHVSR), which is called earthquake-to-microtremor ratio (EMR), has also been proposed for strong-motion sites in Japan. However, the applicability of EMR outside of Japan may not be warranted. We test EMR applicability for the Grenoble basin in France with plentiful microtremor data together with observed weak-motion recordings at five sites. We thereby establish a systematic procedure to estimate the velocity structure from microtremors and delineate the fundamental characteristics of the velocity structures. We first calculate the EMR specific for the Grenoble basin (EMRG) and calculate pseudo eHVSR (pHVSR) from EMRG and mHVSR. We compare the pHVSRs with the eHVSRs at five sites and find sufficient similarity to each other. Then, we invert velocity structures from eHVSRs, pHVSRs, and mHVSRs. The velocity structures from eHVSRs are much closer to those from pHVSRs than those from mHVSRs. We need to introduce a number of layers with gradually increasing S-wave velocities below the geological basin boundary from a previous gravity study because the theoretical eHVSR of the model with a large velocity contrast has larger peak amplitudes than the observed. The depth of the S-wave velocity of 1.3  km/s (Z1.3) shows a strong, linear correlation with the geological boundary depth. Finally, we apply our validated methodology and invert velocity structures using pHVSRs at 14 sites where there are no observed earthquakes. The overall picture of Z1.3 at a cross section in the northeastern part of the basin corresponds to the geological boundary.
Interação entre fatores ambientais, saúde, eficiência produtiva e reprodutiva de vacas holandesas em free stall
Authors: Fernandes Leidiane Gonçalves , Marques Thaisa Campos , Leão Karen Martins , Paim Tiago Do Prado 
Published: February 2021

<p class="Normal1"><span class="fontstyle0">The objective of this study was to evaluate the interaction of environmental factorsin calving and first artificial insemination, uterine and udder health, productive and reproductive efficiency of lactating Holstein cows in free stall. Ideagri® and Dairy Plan® software were used to collect dataof production, reproduction and health data of 321 lactating cows.ADAMA Clima® software provided temperature and relative humidity data to calculate the temperature and humidity index. Environmental variables were evaluated as for season by means of analysis of variance (ANOVA) and means compared by the Kruskal-Wallis test. The effects of the birth season and artificial insemination on the 60th-day pregnancy rate were assessed by logistic regression in the Software R “aod” package, the differences between the average pregnancy rates of each season were determined by the Chi-test Square. Pregnancy rate at the 60th day after the first postpartum artificial insemination was positively influenced on the fourth lactation, and negatively by the occurrence of placental retention during the warm seasons in which the artificial insemination was performed. The placental retention and artificial insemination season with temperature and humidity index&gt;80 interfered with reproductive efficiency. </span></p>
The Extent of the Ability of Student-Teachers to Observe Talent Indicators: A Case Study of Pupils of Basic Education Department
Authors: Osman Abdelrahman Amina Mohammed 
Published: February 2021

This study aimed at investigating the level of the student-teachers' awareness of indicators among Primary School pupils. To achieve this objective, the researcher used the descriptive analytical method. The study sample consisted of (42) fourth-year students in the Faculty of Education, Sudan University of Science and Technology who were being trained in basic schools and were selected using the purposive method. The questionnaire was designed and used to collect data related to talent indicators. The coefficient of correlation Pearson and the alpha Cronbach coefficient and test (t) were used for one group. The results revealed that the total degree of student-teachers' awareness was generally high. There were statistically significant differences between the student-teachers' awareness and pupils' cognitive, social, emotional and creative indicators. In the light of these results, it is recommended that attention should be paid to teacher preparation programs in the faculties of education, where the skills of dealing with talented pupils as well as observation skills of student-teachers should be developed.
Keywords: degree of awareness, student-teacher, Basic Education Department, indicators, talent, basic pupils