bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘The wairua first brings you together’: Māori experiences of meaningful connection in neurorehabilitation
Authors: Wilson Bobbie-Jo , Bright Felicity A. S. , Cummins Christine , Elder Hinemoa , Kayes Nicola M. 
Published: December 2021

AbstractBackground and Aims:Therapeutic connections enhance patient experience and outcomes after neurological injury or illness. While we have some understanding of the components necessary to optimise therapeutic connections, these have developed from western-centric ideals. This study sought to explore the perspectives of Māori brain injury survivors, and their whānau (wider family and community), to develop more culturally informed understandings of what matters most for Māori in the development and experience of therapeutic connection.Design and Methods:A bicultural approach underpinned by principles of Kaupapa Māori Research was used. Whānau views and experiences were gathered through wānanga (focus groups). These perspectives were analysed drawing on Māori methods of noho puku (self-reflection), whanaungatanga (relational linkage) and kaitiakitanga (guardianship).Findings:Three wānanga were held with 16 people – 5 brain injury survivors and 11 whānau members. The phrase ‘therapeutic connection’ did not resonate; instead, people spoke of meaningful connections. For rehabilitation encounters to be meaningful, three layers of connection were acknowledged. The elemental layer features wairua (spirit) and hononga (connection) which both underpinned and surrounded interactions. The relational layer reflects the importance of whānau identity and collectivism, of being valued, known, and interactively spoken with. Finally, the experiential layer consists of relational aspects important within the experience: relationships of reciprocity that are mana-enhancing and grounded in trust. These layers are interwoven, and together serve as a framework for meaningful connections.Conclusions:Meaningful connections in neurorehabilitation are underpinned by wairua and hononga; are multi-layered; are enabled through interactions with people, practice, process and place; are inclusive of whānau and resonate with Māori worldviews. The primacy of wairua and whānau within an interconnected view of health, challenges individualistic notions inherent in western health models and deepens existing understandings of meaningful connections in neurorehabilitation which can guide future rehabilitation research, teaching and practice.
Delayed recovery from severe acute respiratory syndrome coronavirus-2 related anosmia predicts incomplete olfactory restoration
Authors: Fernandez I J , Molinari G , Federici G , Silvestri M , De Corso E , Presutti L , Alicandri-Ciufelli M , Lucidi D 
Published: December 2021

AbstractObjectiveThis study aimed to assess the olfactory recovery rates and patterns in a cohort of coronavirus disease 2019 positive patients, and to investigate the clinical predictors of poor long-term olfactory restoration.MethodsAn observational retrospective study was conducted on 146 patients between September 2020 and January 2021 at a tertiary referral hospital. Coronavirus disease 2019 positive patients with olfactory dysfunction were sent a modified version of the COVID-19 Anosmia Reporting Tool for Clinicians via e-mail.ResultsThe difference in median recovery time between complete recovery and incomplete or no recovery was statistically significant. On multivariate analysis, the only significant factor associated with incomplete or no recovery was anosmia duration.ConclusionAfter a mean time of 5.6 months from severe acute respiratory syndrome coronavirus-2 infection, persistent olfactory disorders were self-reported in 36.7 per cent of patients. Complete recovery was more likely to occur within 15 days. Given the high prevalence of coronavirus disease 2019, a large number of patients are expected to suffer from long-term olfactory morbidity.
Host specificity and the reproductive strategies of parasites
Authors: Doherty Jean-François , Milotic Marin , Filion Antoine , Eriksson Alan 
Published: December 2021

AbstractEnvironmental stability can have profound impacts on life history trait evolution in organisms, especially with respect to development and reproduction. In theory, free-living species, when subjected to relatively stable and predictable conditions over many generations, should evolve narrow niche breadths and become more specialized. In parasitic organisms, this level of specialization is reflected by their host specificity. Here, we tested how host specificity impacts the reproductive strategies of parasites, a subject seldomly addressed for this group. Through an extensive review of the literature, we collated a worldwide dataset to predict, through Bayesian multilevel modelling, the effect of host specificity on the reproductive strategies of parasitic copepods of fishes or corals. We found that copepods of fishes with low host specificity (generalists) invest more into reproductive output with larger clutch sizes, whereas generalist copepods of corals invest less into reproductive output with smaller clutch sizes. The differences in host turnover rates through an evolutionary timescale could explain the contrasting strategies across species observed here, which should still favour the odds of parasites encountering and infecting a host. Ultimately, the differences found in this study reflect the unique evolutionary history that parasites share both intrinsically and extrinsically with their hosts.
Interrogating the validity of cumulative indices of environmental and genetic risk for negative developmental outcomes
Authors: Widaman Keith F. 
Published: December 2021

AbstractIndices of cumulative risk (CR) have long been used in developmental research to encode the number of risk factors a child or adolescent experiences that may impede optimal developmental outcomes. Initial contributions concentrated on indices of cumulative environmental risk; more recently, indices of cumulative genetic risk have been employed. In this article, regression analytic methods are proposed for interrogating strongly the validity of risk indices by testing optimality of compositing weights, enabling more informative modeling of effects of CR indices. Reanalyses of data from two studies are reported. One study involved 10 environmental risk factors predicting Verbal IQ in 215 four-year-old children. The second study included an index of genetic CR in a G×E interaction investigation of 281 target participants assessed at age 15 years and then again at age 31 years for observed hostility during videotaped interactions with close family relations. Principles to guide evaluation of results of statistical modeling are presented, and implications of results for research and theory are discussed. The ultimate goals of this paper are to develop stronger tests of conjectures involving CR indices and to promote methods for improving replicability of results across studies.
Discourse fluency modulates spoken word recognition in monolingual and L2 speakers
Authors: Botezatu Mona Roxana , Kroll Judith F. , Trachsel Morgan , Guo Taomei 
Published: December 2021

AbstractWe investigated whether fluent language production is associated with greater skill in resolving lexical competition during spoken word recognition and ignoring irrelevant information in non-linguistic tasks. Native English monolinguals and native English L2 learners, who varied on measures of discourse/verbal fluency and cognitive control, identified spoken English words from dense (e.g., BAG) and sparse (e.g., BALL) phonological neighborhoods in moderate noise. Participants were slower in recognizing spoken words from denser neighborhoods. The inhibitory effect of phonological neighborhood density was smaller for English monolinguals and L2 learners with higher speech production fluency, but was unrelated to cognitive control as indexed by performance on the Simon task. Converging evidence from within-language effects in monolinguals and cross-language effects in L2 learners suggests that fluent language production involves a competitive selection process that may not engage all domain-general control mechanisms. Results suggest that language experience may capture individual variation in lexical competition resolution.
What the Climber Saw: Strauss's Alpensinfonie and the Romantic Tradition of Nature Representation
Authors: Larkin David 
Published: December 2021

Initially criticized for its naïve representation of landscape features, Strauss's Alpensinfonie (1915) has in recent years been reinterpreted by scholars as a deliberate challenge to metaphysics, a late outgrowth of the composer's fascination with Nietzsche. As a consequence, the relationship between Strauss's tone poem and earlier artworks remains underexplored. Strauss in fact relied heavily on long-established tropes of representing mountain scenes, and when this work is situated against a backdrop of similarly themed Romantic paintings, literature, travelogues and musical compositions, many points of resemblance emerge. In this article, I focus on how human responses to mountains are portrayed within artworks. Romantic-era reactions were by no means univocal: mountains elicited overtly religious exhalations, atheistic refutations of all supernatural connections, pantheistic nature-worship, and also artworks which engaged with nature purely in an immanent fashion.Strauss uses a range of strategies to distinguish the climber from the changing scenery he traverses. The ascent in the first half of Eine Alpensinfonie focuses on a virtuoso rendition of landscape in sound, interleaved with suggestions as to the emotional reactions of the protagonist. This immanent perspective on nature would accord well with Strauss's declared atheism. In the climber's response to the sublime experience of the peak, however, I argue that there are marked similarities to the pantheistic divinization of nature such as was espoused by the likes of Goethe, whom Strauss admired enormously. And while Strauss's was an avowedly godless perspective, I will argue in the final section of the article that he casts the climber's post-peak response to the sublime encounter in a parareligious light that again has romantic precedents. There are intimations of romantic transcendence in the latter part of the work, even if these evaporate as the tone poem, and the entire nineteenth-century German instrumental tradition it concludes, fades away into silence.
Coral Oxygen Isotopic Records Capture the 2015/2016 El Niño Event in the Central Equatorial Pacific
Authors: O’Connor Gemma K. , Cobb Kim M. , Sayani Hussein R. , Atwood Alyssa R. , Grothe Pamela R. , Stevenson Samantha , Baum Julia K. , Chen Tianran , Claar Danielle C. , Hitt Nicholas T. , Lynch‐Stieglitz Jean , Mortlock Richard A. , Schmidt Gavin A. , Walter Rachel 
Published: December 2021

AbstractCoral oxygen isotopes (δ18O) from the central equatorial Pacific provide monthly resolved records of El Niño‐Southern Oscillation activity over past centuries to millennia. However, calibration studies using in situ data to assess the relative contributions of warming and freshening to coral δ18O records are exceedingly rare. Furthermore, the fidelity of coral δ18O records under the most severe thermal stress events is difficult to assess. Here, we present six coral δ18O records and in situ temperature, salinity, and seawater δ18O data from Kiritimati Island (2°N, 157°W) spanning the very strong 2015/16 El Niño event. Local sea surface temperature (SST) anomalies of +2.4 ± 0.4°C and seawater δ18O anomalies of −0.19 ± 0.02‰ contribute to the observed coral δ18O anomalies of −0.58 ± 0.05‰, consistent with a ∼70% contribution from SST and ∼30% from seawater δ18O. Our results demonstrate that Kiritimati coral δ18O records can provide reliable reconstructions even during the largest class of El Niño events.
Modulation of Effective Precipitation by Temperature in the East Asian Monsoon Margins During Marine Isotope Stage 5
Authors: Li Tao , Hedding David William , Chen Jun , Li Gaojun 
Published: December 2021

AbstractProjecting future changes in effective precipitation under global warming, which requires constraints on both the precipitation and evapotranspiration, is still challenging in the semi‐arid region of East Asia. Here we present proxies, based on Sr/Ca and 87Sr/86Sr of soil carbonate, to reconstruct the evolution of both effective precipitation and temperature from a high‐resolution loess profile in the East Asian monsoon marginal area covering the last interglacial period as a geological analog for future conditions. We find that intervals with a stronger summer monsoon are characterized by lower effective precipitation during Marine Isotope Stage (MIS) 5 due to a larger increase in evapotranspiration than in monsoonal precipitation in response to higher temperature. The greater response of the effective precipitation to temperature than summer monsoon intensity during MIS 5 thus suggests the risk of further aridification in the semi‐arid region of East Asia under climate warming.
Orphan cytochrome P450 20a1 CRISPR/Cas9 mutants and neurobehavioral phenotypes in zebrafish
Authors: Brun Nadja R. , Salanga Matthew C. , Mora-Zamorano Francisco X. , Lamb David C. , Goldstone Jared V. , Stegeman John J. 
Published: December 2021

AbstractOrphan cytochrome P450 (CYP) enzymes are those for which biological substrates and function(s) are unknown. Cytochrome P450 20A1 (CYP20A1) is the last human orphan P450 enzyme, and orthologs occur as single genes in every vertebrate genome sequenced to date. The occurrence of high levels of CYP20A1 transcripts in human substantia nigra and hippocampus and abundant maternal transcripts in zebrafish eggs strongly suggest roles both in the brain and during early embryonic development. Patients with chromosome 2 microdeletions including CYP20A1 show hyperactivity and bouts of anxiety, among other conditions. Here, we created zebrafish cyp20a1 mutants using CRISPR/Cas9, providing vertebrate models with which to study the role of CYP20A1 in behavior and other neurodevelopmental functions. The homozygous cyp20a1 null mutants exhibited significant behavioral differences from wild-type zebrafish, both in larval and adult animals. Larval cyp20a1-/- mutants exhibited a strong increase in light-simulated movement (i.e., light–dark assay), which was interpreted as hyperactivity. Further, the larvae exhibited mild hypoactivity during the adaptation period of the optomotor assays. Adult cyp20a1 null fish showed a pronounced delay in adapting to new environments, which is consistent with an anxiety paradigm. Taken together with our earlier morpholino cyp20a1 knockdown results, the results described herein suggest that the orphan CYP20A1 has a neurophysiological role.
Determining chromosomal arms 1p/19q co-deletion status in low graded glioma by cross correlation-periodogram pattern analysis
Authors: Bhattacharya Debanjali , Sinha Neelam , Saini Jitender 
Published: December 2021

AbstractPrediction of mutational status of different graded glioma is extremely crucial for its diagnosis and treatment planning. Currently FISH and the surgical biopsy techniques are the ‘gold standard’ in the field of diagnostics; the analyses of which helps to decide appropriate treatment regime. In this study we proposed a novel approach to analyze structural MRI image signature pattern for predicting 1p/19q co-deletion status non-invasively. A total of 159 patients with grade-II and grade-III glioma were included in the analysis. These patients earlier underwent biopsy; the report of which confirmed 57 cases with no 1p/19q co-deletion and 102 cases with 1p/19q co-deletion. Tumor tissue heterogeneity was investigated by variance of cross correlation (VoCC). Significant differences in the pattern of VoCC between two classes was quantified using Lomb-Scargle (LS) periodogram. Energy and the cut-off frequency of LS power spectral density were derived and utilized as the features for classification. RUSBoost classifier was used that yield highest classification accuracy of 84% for G-II and 87% for G-III glioma respectively in classifying 1p/19q co-deleted and 1p/19q non-deleted glioma. In clinical practice the proposed technique can be utilized as a non-invasive pre-confirmatory test of glioma mutation, before wet-lab validation.
Single-pixel polarimetric direction of arrival estimation using programmable coding metasurface aperture
Authors: Hoang The Viet , Fusco Vincent , Abbasi Muhammad Ali Babar , Yurduseven Okan 
Published: December 2021

AbstractThis paper presents a single-pixel polarimetric compressive sensing (CS)-based direction of arrival (DoA) estimation technique using a cavity backed programmable coding metasurface aperture. The single-pixel DoA retrieval technique relies on a dynamically modulated waveform diversity, enabling spatially incoherent radiation masks to encode the incoming plane waves on the radar aperture using a single channel. The polarimetric nature of the wave-chaotic coded metasurface ensures that the DOA estimation is sensitive to the polarization state of the incoming waves. We show that the polarimetric single-pixel DoA concept can be realized by encoding the polarization information of the incoming waves at the physical layer level within the antenna. A dynamically reconfigurable wave-chaotic metasurface, which possesses a structured sparsity of dual-polarized coded metamaterial elements, is proposed for the proof of concept. It is shown that by encoding and compressing the source generated far-field incident waves into a single channel, we can retrieve high fidelity polarimetric DoA information from compressed measurements.
The effectiveness of commercial household ultraviolet C germicidal devices in Thailand
Authors: Palakornkitti Pasita , Pinyowiwat Prinpat , Tanrattanakorn Somsak , Rajatanavin Natta , Rattanakaemakorn Ploysyne 
Published: December 2021

AbstractUltraviolet C (UVC), or ultraviolet germicidal irradiation (UVGI), is known for its effective air, water, and surface disinfectant properties. With the rise of global awareness about public sanitation and personal hygiene due to the emergence of the current coronavirus disease 2019 pandemic, several applications of UVC were introduced to the commercial market. The present experimental study aimed to evaluate the effectiveness of commercial household UVC germicidal devices for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inactivation. Ten UVC devices were included in the study comprising of 7 low-pressure mercury lamps (LPMLs) and 3 UVC- light-emitting diodes (LEDs). Considering applications, 3 were handheld UVGI surface disinfection equipment, 4 were UVGI disinfection chambers, and 3 were movable UVGI air and surface purifiers. To determine SARS-CoV-2 inactivation performance, UVC irradiance (mW/cm2) was measured 3 times repeatedly at distance and duration corresponding to manufacturers’ usage instructions. The required UVC dosage could not be achieved by either of UVC-LED devices (1 handheld UVGI surface disinfection equipment and 2 UVGI disinfection chambers). Five of seven LPMLs can sufficiently emit UVC irradiance for SARS-CoV-2-inactivation. A lack of standardization in the distance and cycle duration for each UVC application was observed. Standard usage guidelines for UVC devices are required to improve the effectiveness of UVC irradiance for SARS-CoV-2 inactivation as well as to minimize the potential side effects of UVC.
The role of folded fibular flap in patients’ reconstruction of mandibular defects: a retrospective clinical study
Authors: Gao Ning , Fu Kun , Cai Jinghua , Chen Hao , He Wei 
Published: December 2021

AbstractThis study has analyzed 41 patients with mandibular ameloblastoma who underwent a partial mandibulectomy and reconstruction by folding the free fibular flap. In the preoperative and postoperative (6 months and 24 months after surgery), the Quality of Life (QOL) of these patients was assessed by using the University of Washington Quality of Life Questionnaire (UW-QOL) and the medical outcome study short form-36 (SF-36) questionnaires. SPSS 20.0 statistical software was used to conduct statistical analysis on the base data of the two groups of patients. Independent sample t test was conducted for sf-36 and UW-QOL scores at two time points in each group. The SF-36 survey showed that body pain (54.54 ± 8.10), general health (55.27 ± 7.54), and health changes (58.29 ± 9.60) decreased significantly at 6 months after surgery, but the mean score at 24 months after surgery all exceeded the preoperational level. At 24 months after the surgery, the vitality (80.41 ± 3.74), social function (81.61 ± 4.07), emotional role (82.39 ± 4.07), psychological health (81.66 ± 4.37) and total score (704.00 ± 31.53) all returned to the preoperative level, which was statistically significant compared with 6 months after surgery. However, there was no significant difference compared with the preoperative level. The UW-QOL survey showed that chewing (56.68 ± 7.23), speech (54.54 ± 7.7) and taste (62.29 ± 10.15) have significantly changed at 6 months after the surgery, and the difference was statistically significant at 24 months after surgery. Saliva generation decreased slightly (80.76 ± 3.35) at 6 months after surgery, but quickly returned to the preoperative level (81.59 ± 4.06). The total score of the patients almost recovered to the preoperative level at 24 months after surgery. The folded the fibular flap can not only repair the defects of soft tissue and bone tissue, but also restore the height of the alveolar ridge to, avoid the imbalance of crown and root ratio after implantation and reduce the occurrence of peri-implant inflammation, so that a true functional reconstruction can be realized.
Effectiveness of LODS, OASIS, and SAPS II to predict in-hospital mortality for intensive care patients with ST elevation myocardial infarction
Authors: Wang Liang , Zhang Zhengwei , Hu Tianyang 
Published: December 2021

AbstractThe relationship between three scoring systems (LODS, OASIS, and SAPS II) and in-hospital mortality of intensive care patients with ST segment elevation myocardial infarction (STEMI) is currently inconclusive. The baseline data, LODS score, OASIS score, SAPS II score, and in-hospital prognosis of intensive care patients with STEMI were retrieved from the Medical Information Mart for Intensive Care IV database. Propensity score matching analysis was performed to reduce bias. Receiver operating characteristic curves (ROC) were drawn for the three scoring systems, and comparisons between the areas under the ROC curves (AUC) were conducted. Decision curve analysis (DCA) was performed to determine the net benefits of the three scoring systems. LODS and SAPS II were independent risk factors for in-hospital mortality. For the study cohort, the AUCs of LODS, OASIS, SAPS II were 0.867, 0.827, and 0.894; after PSM, the AUCs of LODS, OASIS, SAPS II were 0.877, 0.821, and 0.881. A stratified analysis of the patients who underwent percutaneous coronary intervention/coronary artery bypass grafting (PCI/CABG) or not was conducted. In the PCI/CABG group, the AUCs of LODS, OASIS, SAPS II were 0.853, 0.825, and 0.867, while in the non-PCI/CABG group, the AUCs of LODS, OASIS, SAPS II were 0.857, 0.804, and 0.897. The results of the Z test suggest that the predictive value of LODS and SAPS II was not statistically different, but both were higher than OASIS. According to the DCA, the net clinical benefit of LODS was the greatest. LODS and SAPS II have excellent predictive value, and in most cases, both were higher than OASIS. With a more concise composition and greater clinical benefit, LODS may be a better predictor of in-hospital mortality for intensive care patients with STEMI.