bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biogeochemical consequences of a changing Arctic shelf seafloor ecosystem
Authors: März Christian , Freitas Felipe S. , Faust Johan C. , Godbold Jasmin A. , Henley Sian F. , Tessin Allyson C. , Abbott Geoffrey D. , Airs Ruth , Arndt Sandra , Barnes David K. A. , Grange Laura J. , Gray Neil D. , Head Ian M. , Hendry Katharine R. , Hilton Robert G. , Reed Adam J. , Rühl Saskia , Solan Martin , Souster Terri A. , Stevenson Mark A. , Tait Karen , Ward James , Widdicombe Stephen 
Published: October 2021

AbstractUnprecedented and dramatic transformations are occurring in the Arctic in response to climate change, but academic, public, and political discourse has disproportionately focussed on the most visible and direct aspects of change, including sea ice melt, permafrost thaw, the fate of charismatic megafauna, and the expansion of fisheries. Such narratives disregard the importance of less visible and indirect processes and, in particular, miss the substantive contribution of the shelf seafloor in regulating nutrients and sequestering carbon. Here, we summarise the biogeochemical functioning of the Arctic shelf seafloor before considering how climate change and regional adjustments to human activities may alter its biogeochemical and ecological dynamics, including ecosystem function, carbon burial, or nutrient recycling. We highlight the importance of the Arctic benthic system in mitigating climatic and anthropogenic change and, with a focus on the Barents Sea, offer some observations and our perspectives on future management and policy.
One-year follow-up—case report of secondary tension pneumothorax in a COVID-19 pneumonia patient
Authors: Endres Felix , Spiro Judith Eva , Bolt Toki Anna , Tufman Amanda , Ockert Ben , Helfen Tobias , Gilbert Fabian , Holzapfel Boris M. , Böcker Wolfgang , Siebenbürger Georg 
Published: October 2021

Abstract
Purpose
The Coronavirus Disease 2019 (COVID-19) may result not only in acute symptoms such as severe pneumonia, but also in persisting symptoms after months. Here we present a 1 year follow-up of a patient with a secondary tension pneumothorax due to COVID-19 pneumonia.

Case presentation
In May 2020, a 47-year-old male was admitted to the emergency department with fever, dry cough, and sore throat as well as acute chest pain and shortness of breath. Sputum testing (polymerase chain reaction, PCR) and computed tomography (CT) confirmed infection with the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Eleven days after discharge, the patient returned to the emergency department with pronounced dyspnoea after coughing. CT showed a right-sided tension pneumothorax, which was relieved by a chest drain (Buelau) via mini open thoracotomy. For a period of 3 months following resolution of the pneumothorax the patient complained of fatigue with mild joint pain and dyspnoea. After 1 year, the patient did not suffer from any persisting symptoms. The pulmonary function and blood parameters were normal, with the exception of slightly increased levels of D-Dimer. The CT scan revealed only discrete ground glass opacities (GGO) and subpleural linear opacities.

Conclusion
Tension pneumothorax is a rare, severe complication of a SARS-CoV-2 infection but may resolve after treatment without negative long-term sequelae.

Level of evidence
V.
Interpolation of Beilinson–Kato elements and p-adic L-functions
Authors: Benois Denis , Büyükboduk Kâzım 
Published: October 2021

AbstractOur objective in this series of two articles, of which the present article is the first, is to give a Perrin-Riou-style construction ofp-adicL-functions (of Bellaïche and Stevens) over the eigencurve. As the first ingredient, we interpolate the Beilinson–Kato elements over the eigencurve (including the neighborhoods of$$\theta $$θ-critical points). Along the way, we prove étale variants of Bellaïche’s results describing the local properties of the eigencurve. We also develop the local framework to construct and establish the interpolative properties of thesep-adicL-functions away from$$\theta $$θ-critical points.
Characterizing financial markets from the event driven perspective
Authors: Torkar Miha , Mladenic Dunja 
Published: October 2021

AbstractIn this work we study how company co-occurrence in news events can be used to discover business links between them. We develop a methodology that is able to process raw textual data, embed it into a numerical form, and extract a meaningful network of connections. Each news event is considered as a node on the graph and we define the similarity between the two events as the cosine similarity between their vectors in the embedded space. Using this procedure, we contribute to the literature by successfully reconstructing business links between companies, which is usually a difficult task since the data on this topic is either outdated, incomplete or not widely available. We then demonstrate possible uses of this network in two forecasting applications. First, we show how the network can be used as an exogenous feature vector, which improves the prediction of the correlation between companies in the network. This correlation is determined from their realized variance as well as using a wide set of machine learning models for prediction. Second, we demonstrate the use of network for predicting future events with point processes. Our methodology can be applied on any series of events, where we have demonstrated and evaluated its applicability on news events and large market moves. For most of the tested algorithms the experimental results show an improvement in performance when including information from our graphs. More specifically, in certain sectors using Neural Networks shows improved performance by up to 50%.
Screening of Solanum (sections Lycopersicon and Juglandifolia) germplasm for reactions to the tomato brown rugose fruit virus (ToBRFV)
Authors: Jewehan Ahmad , Salem Nida , Tóth Zoltán , Salamon Pál , Szabó Zoltán 
Published: October 2021

AbstractThe reaction of 636 Solanum (sections Lycopersicon and Juglandifolia) accessions were evaluated under greenhouse conditions after mechanical inoculation with a Jordanian isolate of the new tobamovirus tomato brown rugose fruit virus (ToBRFV). Local and systemic infections were assayed by symptoms evaluation and virus detection via biotests and RT-PCR. All cultivated tomatoes (Solanum lycopersicum) and the great majority of wild tomato accessions proved susceptible to ToBRFV. They showed a wide range of symptoms (mosaic, leaf deformations, mottling, shoestring, and stunting). Twenty-six accessions representing S. lycopersicum var. cerasiforme, S. pimpinellifolium, S. habrochaites, and S. chilense were tolerant. High levels of resistance have been demonstrated in three accessions of S. ochrantum, a close relative to wild tomatoes (member of the sect. Juglandifolia) not only to ToBRFV but also to the tobamoviruses, tobacco mosaic virus (TMV) and tomato mosaic virus (ToMV). After mechanical inoculation, the three tobamoviruses could be detected only in inoculated leaves in the accessions LA2160, LA2162, and LA 2166, which remained symptomless. However, two other S. ochrantum accessions PI 473,498 and PI 230,519 reacted unusually. They were demonstrated highly resistant to TMV and ToMV, but proved transiently susceptible to ToBRFV showing mild systemic mosaic followed by total recovery from symptoms and the virus.
Relational Autonomy, the Right to Reject Treatment, and Advance Directives in Japan
Authors: Asagumo Anri 
Published: October 2021

AbstractAlthough the patient’s right to decide what they want for themselves, which is encompassed in the notion of ‘patient-centred medicine’ and ‘informed consent’, is widely recognised and emphasised in Japan, there remain grave problems when it comes to respecting the wishes of the no-longer-competent when death is imminent. In general, it is believed that the concepts above do not include the right to refuse treatment when treatment withdrawal inevitably results in death, even when the patient previously expressed the wish to exercise this right when competent. In this paper, I first explain the current social and legal situation in Japan, where the lack of legal clarity regarding the right to reject treatment tends to result in doctors adopting the interpretation of patients’ words that is least conducive to treatment withdrawal. I then argue that the right to refuse treatment should be taken seriously, even when the patient is no longer competent, or the treatment refusal will result in death. I suggest that the concept of relational autonomy might have some practical and valuable implications in a country where individual autonomy is considered incompatible with societal values. Finally, I answer possible objections to relational autonomy and address the widespread societal concern about sliding down the slippery slope from allowing the right to refuse treatment to the obligation to die.
Numerical investigation of mixed convection boundary layer flow for nanofluids under quasilinearization technique
Authors: Maji Srimanta , Sahu Akshaya K. 
Published: October 2021

AbstractThe study of boundary layer flow under mixed convection has been investigated numerically for various nanofluids over a semi-infinite flat plate which has been placed vertically upward for both buoyancy-induced assisting and buoyancy-induced opposing flow cases. To facilitate numerical calculations, a suitable transformation has been made for the governing partial differential equations (PDEs). Then, similarity method has been applied locally to approximate the nonlinear PDEs into a coupled nonlinear ordinary differential equations (ODEs). Then, quasilinearization method has been taken for linearizing the nonlinear terms which are present in the governing equations. Thereafter, implicit trapezoidal rule has been taken for integration numerically along with principle of superposition. The effect of physical parameters which are involved in the study are analyzed on the flow and heat transfer characteristics. This study reveals the presence of dual solutions in case of opposing flow. Further, this study shows that with increasing $$\phi$$
ϕ
and Pr, the range of existence of dual solutions becomes wider. Also, it has been noted that nanofluids enhance the process of heat transfer for buoyancy assisting flow and it delays the separation point in case of opposing flow.
Analysis of Sorghum Stalks and Fibres for Use in the Production of Low-Cost Housing Materials
Authors: Abdel-Magid Taghried , Walker Pete , Paine Kevin , Allen Stephen 
Published: October 2021

AbstractResearch into low-cost housing solutions, especially for low- and middle-income countries, has grown in recent years. Greater use of natural materials, both mineral and bio-based, offers opportunities for more affordable and sustainable materials and products. In the low- and middle-income countries, residential buildings are too expensive for most people due to the use of the concrete in buildings. Utilisation of agricultural wastes can serve a threefold purpose: (i) minimise the impact of construction products on the environment, (ii) reduce waste, and (iii) decrease the cost. The aim of this study was to investigate fibres and stalks from the sorghum plant as potential additives in low-cost brick production. Analysis of the sorghum fibres and stalks has included microstructural examination using a scanning electron microscope and mercury intrusion porosimetry, together with tensile strength testing of fibres. Fibres and stalks did not undergo chemical pre-treatment. Sorghum stalks and fibres were found to have comparable tensile strength to fibres currently used for brick production, and the methods used to prepare stalks were not found to adversely affect their strengths. Consequently, this research has shown that fibres produced from local agricultural wastes have potential for use in low-cost housing such as one-storey residential load-bearing structures and buildings.
U.S. Food and Drug Administration’s Patient-Focused Drug Development Initiative: Experience with Integration of Patient-Experience Data in a New Drug Application for Esketamine Nasal Spray Plus a Newly Initiated Oral Antidepressant for Treatment-Resistant Depression
Authors: Katz Eva G. , McNulty Pauline , Levitan Bennett , Treichler Patricia , Martynowicz Jadwiga , Jamieson Carol 
Published: October 2021

AbstractThe Patient-Focused Drug Development initiative of the U.S. Food and Drug Administration (FDA) aims to ensure that the patient experience of disease and treatment is an integral component of the drug development process. The 21st Century Cures Act and Prescription Drug User Fee Act (PDUFA) VI require the FDA to publicly report the type of patient-experience data reviewed in a new drug application (NDA) to inform regulatory decision-making. This report describes a recent approach adopted at Janssen of integrating patient-experience data into the NDA for esketamine (SPRAVATO®) nasal spray with a newly initiated oral antidepressant (esketamine + AD) for treatment-resistant depression. During the development of esketamine + AD, patient-experience data were collected using several patient-reported outcomes, including the Sheehan Disability Scale and 9-item Patient Health Questionnaire (PHQ-9). Additionally, a patient-preference study assessed the relative importance of benefits and harms that patients allocated to different attributes of treatment. Preferences were collected from patients enrolled in phase 3 esketamine trials and from an online panel of primarily ketamine-naive patients. Patient-experience data were integrated into the esketamine NDA, the FDA advisory committee meeting briefing document, and the Sponsor’s presentation. The FDA acknowledged reviewing the patient-experience data and determined that they supported esketamine + AD for treatment-resistant depression. This report highlights the importance of integrating patient-experience methods early in drug development, their impact on assessing patient-relevant benefits and risks, and how they can help improve clinical program design.
Clinical outcomes of relapsed and refractory Hodgkin lymphoma patients after contemporary first-line treatment: a German Hodgkin Study Group analysis
Authors: Bröckelmann Paul J. , Müller Horst , Gillessen Sarah , Yang Xiaoqin , Koeppel Larissa , Pilz Veronika , Marinello Patricia , Kaskel Peter , Raut Monika , Fuchs Michael , Borchmann Peter , Engert Andreas , von Tresckow Bastian 
Published: October 2021

AbstractTo evaluate patterns of rrHL after contemporary first-line treatment we studied 409 patients with first rrHL (HD13: n = 87, HD14: n = 118, HD15: n = 188, HDR3i: n = 51) at a median age of 37.4 years (18.4–76.8) from the GHSG database. Time to first relapse was ≤12 months in 49% and stage III/IV rrHL present in 52% of patients. In total, 291 patients received high-dose chemotherapy and autologous stem-cell transplantation (ASCT) and intended ASCT failed in 38 patients. ASCT was primarily not intended in 80 patients largely due to low risk disease or age/comorbidities. Overall, 10-year progression-free (PFS) and overall survival (OS) rates after first relapse were 48.2% (95% CI 41.9–54.2%) and 59.4% (95% CI 53.0–65.2%), respectively, with significant differences between subgroups. Inferior survival was observed with no ASCT due to advanced age/comorbidities (five-year PFS 36.2%, 95% CI 17.7–55.0%) or failure of salvage therapy (five-year PFS 36.3%, 95% CI 19.7–53.2%). Similarly, presence of primary refractory disease or stage IV at rrHL conferred inferior survival. In patients with low-risk disease, however, survival appeared favorable even without ASCT (10 y PFS 72.6%, 95% CI 53.7–84.8%). We herein confirm the curative potential of current rrHL treatments providing a robust benchmark to evaluate novel therapeutic strategies in rrHL. Approximately 50% of rrHL patients experienced a consecutive relapse.
Inter-species interactions alter antibiotic efficacy in bacterial communities
Authors: Bottery Michael J , Matthews Jessica L , Wood A Jamie , Johansen Helle Krogh , Pitchford Jon W , Friman Ville-Petri 
Published: October 2021

Abstract
The efficacy of antibiotic treatments targeting polymicrobial communities is not well predicted by conventional in vitro susceptibility testing based on determining minimum inhibitory concentration (MIC) in monocultures. One reason for this is that inter-species interactions can alter the community members’ susceptibility to antibiotics. Here we quantify, and identify mechanisms for, community-modulated changes of efficacy for clinically relevant antibiotics against the pathogen Pseudomonas aeruginosa in model cystic fibrosis (CF) lung communities derived from clinical samples. We demonstrate that multi-drug resistant Stenotrophomonas maltophilia can provide high levels of antibiotic protection to otherwise sensitive P. aeruginosa. Exposure protection to imipenem was provided by chromosomally encoded metallo-β-lactamase that detoxified the environment; protection was dependent upon S. maltophilia cell density and was provided by S. maltophilia strains isolated from CF sputum, increasing the MIC of P. aeruginosa by up to 16-fold. In contrast, the presence of S. maltophilia provided no protection against meropenem, another routinely used carbapenem. Mathematical ordinary differential equation modelling shows that the level of exposure protection provided against different carbapenems can be explained by differences in antibiotic efficacy and inactivation rate. Together, these findings reveal that exploitation of pre-occurring antimicrobial resistance, and inter-specific competition, can have large impacts on pathogen antibiotic susceptibility, highlighting the importance of microbial ecology for designing successful antibiotic treatments for multispecies communities.
Influence of polygenic risk scores for schizophrenia and resilience on the cognition of individuals at-risk for psychosis
Authors: He Qin , Jantac Mam-Lam-Fook Célia , Chaignaud Julie , Danset-Alexandre Charlotte , Iftimovici Anton , Gradels Hauguel Johanna , Houle Gabrielle , Liao Calwing ,   ICAAR study group, Amado Isabelle , Bourgin Julie , Daban-Huard Claire , Magaud Emilie , Plaze Marion , Rivollier Fabrice , Dion Patrick A. , Rouleau Guy A. , Kebir Oussama , Krebs Marie-Odile , Chaumette Boris 
Published: October 2021

AbstractCognitive impairment is a core feature of schizophrenia which precedes the onset of full psychotic symptoms, even in the ultra-high-risk stage (UHR). Polygenic risk scores (PRS) can be computed for many psychiatric disorders and phenotyping traits, including scores for resilience. We explored the correlations between several PRS and neurocognition in UHR individuals. We included 107 UHR individuals; 29.9% of them converted to psychosis (UHR-C) while 57.0% did not (UHR-NC) during the 1-year follow-up. Cognitive performances were assessed with the Wechsler Adult Intelligence Scale estimating the Intelligence Quotient (IQ), the Trail Making Test, the verbal fluency, the Stroop test, and the Wisconsin card sorting test. Linear regression models were used to test their association with the PRS for schizophrenia, bipolar disorder, major depression, ADHD, cross-disorders, cognitive performance, intelligence, education attainment, and resilience to schizophrenia. UHR-C had a lower IQ than UHR-NC. The PRS for schizophrenia negatively correlated with IQ, while the PRS for cognitive performance and for resilience positively correlated with IQ. PRS for schizophrenia showed a significant correlation with working memory and processing speed indices. PRS for schizophrenia showed a higher effect on IQ in UHR-NC, and UHR-NC with high PRS for schizophrenia had a similar IQ as UHR-C. Conversely, UHR-C with a high PRS for resilience performed as well as UHR-NC. Our findings suggest that cognitive deficits may predate the onset of psychosis. The genetic architecture of schizophrenia seems to impacts the cognition in UHR-NC. Cognition is also mediated by PRS for resilience.
p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl4
Authors: Humpton Timothy J. , Hall Holly , Kiourtis Christos , Nixon Colin , Clark William , Hedley Ann , Shaw Robin , Bird Thomas G. , Blyth Karen , Vousden Karen H. 
Published: October 2021

AbstractThe p53 transcription factor coordinates wide-ranging responses to stress that contribute to its function as a tumour suppressor. The responses to p53 induction are complex and range from mediating the elimination of stressed or damaged cells to promoting survival and repair. These activities of p53 can modulate tumour development but may also play a role in pathological responses to stress such as tissue damage and repair. Using a p53 reporter mouse, we have previously detected strong induction of p53 activity in the liver of mice treated with the hepatotoxin carbon tetrachloride (CCl4). Here, we show that p53 functions to support repair and recovery from CCl4-mediated liver damage, control reactive oxygen species (ROS) and limit the development of hepatocellular carcinoma (HCC), in part through the activation of a detoxification cytochrome P450, CYP2A5 (CYP2A6 in humans). Our work demonstrates an important role for p53-mediated redox control in facilitating the hepatic regenerative response after damage and identifies CYP2A5/CYP2A6 as a mediator of this pathway with potential prognostic utility in human HCC.
p53-dependent induction of P2X7 on hematopoietic stem and progenitor cells regulates hematopoietic response to genotoxic stress
Authors: Tung Lin Tze , Wang HanChen , Belle Jad I. , Petrov Jessica C. , Langlais David , Nijnik Anastasia 
Published: October 2021

AbstractStem and progenitor cells are the main mediators of tissue renewal and repair, both under homeostatic conditions and in response to physiological stress and injury. Hematopoietic system is responsible for the regeneration of blood and immune cells and is maintained by bone marrow-resident hematopoietic stem and progenitor cells (HSPCs). Hematopoietic system is particularly susceptible to injury in response to genotoxic stress, resulting in the risk of bone marrow failure and secondary malignancies in cancer patients undergoing radiotherapy. Here we analyze the in vivo transcriptional response of HSPCs to genotoxic stress in a mouse whole-body irradiation model and, together with p53 ChIP-Seq and studies in p53-knockout (p53KO) mice, characterize the p53-dependent and p53-independent branches of this transcriptional response. Our work demonstrates the p53-independent induction of inflammatory transcriptional signatures in HSPCs in response to genotoxic stress and identifies multiple novel p53-target genes induced in HSPCs in response to whole-body irradiation. In particular, we establish the direct p53-mediated induction of P2X7 expression on HSCs and HSPCs in response to genotoxic stress. We further demonstrate the role of P2X7 in hematopoietic response to acute genotoxic stress, with P2X7 deficiency significantly extending mouse survival in irradiation-induced hematopoietic failure. We also demonstrate the role of P2X7 in the context of long-term HSC regenerative fitness following sublethal irradiation. Overall our studies provide important insights into the mechanisms of HSC response to genotoxic stress and further suggest P2X7 as a target for pharmacological modulation of HSC fitness and hematopoietic response to genotoxic injury.