bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of cytomegalovirus infection on nucleoside diphosphatase activity in placenta
Authors: Dovzhikova I. V. , Andrievskaya I. A. , Ishutina N. A. , Dorofienko N. N. , Gorikov I. N. 
Published: April 2021

Introduction. Cytomegalovirus infection (CMVI) makes a significant contribution to the development of pregnancy pathologies, including dysfunction of the placenta. However, the mechanism of such an effect of CMV has not been precisely established. For the coordination of biochemical reactions in the placenta, an optimal concentration of substances, including nucleotides, is required. Nucleoside diphosphatase is an enzyme that catalyzes the hydrolysis of nucleotide diphosphates to nucleotide and phosphate.Aim. Determination of the activity of nucleoside diphosphatase in the placenta in physiological and complicated CMVI reactivation in the third trimester of pregnancy.Materials and methods. A study of 62 placentas obtained during childbirth at 38-40 weeks was carried out. The first group consisted of the placentas from women with CMVI reactivation in the third trimester of pregnancy and the second – the placenta of women without a history of infectious pathology. Diagnosis of CMVI was carried out by determining antibodies of class M and G by ELISA, as well as CMV DNA was detected by PCR. Histochemical analysis of nucleoside diphosphatase was performed according to the method of A.B.Novikoff and D.S.Goldfischer modified by Z.Lojda et al.Results. In the second group, the placenta nucleoside-diphosphatase had a pronounced activity in the syncytiotrophoblast and the connective tissue stroma of the villi. When CMVI was reactivated in the third trimester of pregnancy, a decrease in the intensity of the histochemical reaction to nucleoside-diphosphatase was found: the cytophotometric index in the first group significantly (p<0.001) decreased to 13.06±0.089 rel. units (in the second group it was 14.11±0.119 relative units).Conclusion. The decrease in the activity of nucleoside diphosphatase found during the reactivation of CMVI in the third trimester of pregnancy might indicate a decrease in nucleotide metabolism in the placenta. In our opinion, the study of enzymes involved in the exchange of nucleotides will help to reveal the mechanisms by which CMV causes disturbances in the functioning of the placenta, leading to the development of complications of pregnancy.
Phospholipid profiles and annexin V content in villous chorion from women with spontaneous miscarriage associated with cytomegalovirus infection
Authors: Ishutina N. A. , Andrievskaya I. A. , Prikhodko N. G. 
Published: April 2021

Aim. To carry out a comparative analysis of the phospholipid profiles and annexin V content in the villous chorion obtained from women with spontaneous abortion associated with exacerbation of cytomegalovirus infection (CMVI) and the physiological course of pregnancy.Materials and methods. 66 patients were randomly selected at a gestational age of 6-8 weeks. A control group was identified in the amount of 32 healthy pregnant women with medical abortion. The main study group consisted of 34 women with spontaneous abortion associated with exacerbation of cytomegalovirus CMVI. The material for the study was the villous chorion, peripheral blood and urine. Type-specific antibodies to CMV immunoglobulins M and G class and the avidity index were determined in blood serum by the method of enzyme-linked immunosorbent assay. Lipids in the villous chorion homogenate were extracted with a chloroform-methanol mixture, phospholipids were fractionated by thin layer chromatography. The quantitative determination of annexin V was carried out by the method of enzyme immunoassay.Results. The phospholipid profile of the villous chorion in the main group was characterized by a decrease in the fraction of phosphatidylcholine to 22,39±0,04% (control group – 28,50±0,052%; p<0,001), phosphatidylethanolamine to 27,63±0,011% (control group – 30,11±0,073%; p<0,001), phosphatidylinositol up to 14,24±0,021% (control group – 16,17±0,018%; p<0,001), an increase in lysophosphatidylcholine up to 2,25±0,032% (control group – 1,07±0,022%; p<0,001), phosphatidylserine up to 14,57±0,075% (control group – 10,02±0,012%; p<0,001), sphingomyelin up to 18,92±0,012% (control group – 14,13±0,012%; p<0,001). At the same time, an increase in the content of annexin V was revealed up to 43,12±0,50 U/mL (control group – 20,21±0,50 U/mL; p<0,001).Conclusion. The results of the study showed that in the villous chorion from women with spontaneous abortion associated with exacerbation of CMVI, there was a change in the profile and ratio of phospholipids, as well as in the concentration of annexin V. The established increase in the content of phosphatidylserine and the associated annexin V in the villous chorion indicates a violation of the hemostatic system and microcirculation due to increased thrombus formation, which supports local inflammation and apoptosis of the trophoblast, which leads to embryonic demise and spontaneous abortion.
Predicting intrauterine infection risk in newborns based on morphometric parameters of placental terminal villi
Authors: Ostrovskaya О. V. , Suprun S. V. , Kozharskaya O. V. , Musatov D. V. , Ivakhnishina N. M. , Nagovitsyna E. B. , Vlasova M. A. 
Published: April 2021

Aim. To evaluate the prognostic value of micromorphometry of placental terminal villi for early diagnosis of intrauterine infections in newborns.Materials and methods. A molecular genetic and micromorphometric study of 34 placentas obtained from women whose pregnancy ended in preterm labor at 30-36 weeks and 46 placentas of persons who gave birth to full-term babies was performed. In samples of placental tissue, the polymerase chain reaction was used to identify the genome of the following pathogens of intrauterine infections:Mycoplasma hominis,Mycoplasma genitalium,Ureaplasma species(Ureaplasma urealyticum+Ureaplasma parvum),Chlamydia trachomatis,Streptococcus agalactiae,Streptococcus pyogenes,Staphylococcus aureus,Klebsiella pneumoniae,Haemophilus influenza,Listeria monocytogenes,Cytomegalovirus,Herpes simplex virus,Human herpes virus 4 type,Human herpes virus 6 type,Parvovirus B19. Morphometry was performed using an image analysis system on a Carl Zeiss microscope and Axio Imager software. An average number of capillaries in the terminal villi and the distance from the capillaries to the syncytiotrophoblast were calculated.Results. The genome of intrauterine infection pathogens was detected in 55.9% of placentas from preterm birth, including DNA ofUreaplasma species– 29.4%,Mycoplasma hominis– 23.5%,Mycoplasma genitalium– 5.9%,Streptococcus agalactiae– 11.7%,Cytomegalovirus– 5.9%,Human herpes virus 4 type– 14.8% as a part of mono- and co-infections. In full-term pregnancy, the infection of the placentas was found to be 3.4 times less – 16.3% (p<0.0002). In monoinfections, DNA ofUreaplasma species– 4.6%,Mycoplasma hominis– 6.9%,Streptococcus agalactiae– 2.3%,Human herpes virus 4 type– 2.3% were detected. An average number of capillaries (abs. value) in the terminal villi of infected placentas, both at full-term (5.35±1.07) and premature (3.97±0.19) pregnancies, proved to be significantly less than in uninfected placentas (5.74±0.05 and 4.63±0.28), respectively. An average distance from the capillaries (µm) of the terminal villi to the syncytiotrophoblast in infected placentas both at full-term (1.62±0.15) and premature pregnancies (2.20±0.2) proved to be significantly greater than in uninfected placentas (1.02±0.03 and 1.72±0.14, respectively).Conclusion. Comparison of the morphometric parameters of terminal villi in the examined placenta with an average rate of infected and uninfected placentas of full-term and premature pregnancies makes it possible to predict the risk of intrauterine infection in a newborn.
CORRELATION BETWEEN CONSCIENTIOUSNESS AND READING COMPREHENSION ACHIEVEMENT
Authors: Sari Intan Permata , Rosmalina Ida , Erlina Erlina 
Published: April 2021

Conscientiousness is one of the personality traits that defined as an individual tendency to be organized, thorough, controlled, decisive and dependable. This study was done to find out (1) the correlation between conscientiousness and reading comprehension achievement, (2) the significant difference in conscientiousness and reading comprehension achievement between male and female students, (3) the significant difference in conscientiousness and reading comprehension achievement between social science students and natural science students, and (4) the contribution of conscientiousness to reading comprehension achievement. The population of the study was the eleventh grade students of SMA Negeri 20 Palembang. One hundred students were purposively taken as sample on the basis of equal numbers of gender and major. To collect the data, reading comprehension achievement test and conscientiousness questionnaire were distributed to students and analyzed statistically. The findings showed conscientiousness and reading comprehension achievement significantly correlated (p value = 0.460) and the contribution of conscientiousness to reading comprehension achievement was 20.4%. The significant difference in reading comprehension achievement in gender and major was found; female and natural science students were better. The different result was obtained in conscientiousness. It implied that students tend to had similar perception toward conscientiousness regardless their gender and major.
ENGLISH READING MOTIVATION, STRATEGIES, ATTITUDE, AND INTEREST OF STATE JUNIOR HIGH SCHOOL STUDENTS
Authors: Vianty Machdalena , Amrullah Amrullah , Fiftinova Fiftinova 
Published: April 2021

Abstract: The objective of this study was to investigate English reading motivation, reading strategy, reading attitude and reading interest of junior high school students (Year 7, 8 and 9) in Palembang. The sample of this study was three-hundred students selected randomly from ten schools. In accordance with quantitative research design, English reading motivation, reading strategy, reading attitude and reading interest questionnaires were used as the instruments to collect the data which were statistically analyzed. The findings of this study showed that the students demonstrated a high level of English reading motivation; specifically, their instrumental motivation for reading was higher than the integrative one. Next, there was a high use of reading strategies, with Problem-Solving reading strategy as the highly used ones. The finding also revealed that the students demonstrated a positive reading attitude and their reading interest showed their reading preference was adventure stories. Keywords: English reading motivation, reading strategies, reading attitude, reading interest, self-efficacy, junior high school students
THE USE OF LITERATURE-BASED INSTRUCTION TO IMPROVE READING COMPREHENSION AND WRITING ACHIEVEMENTS OF THE EIGHTH GRADE STUDENTS
Authors: Novasyari Ressy 
Published: April 2021

Abstract: This research aimed to investigate whether or not there were significant differences in reading comprehension and writing achievement between the eighth grade students of SMP Islam Az-Zahra 2 Palembang who were taught by using Literature-Based instruction and those who were not. This study used one of the quasi experimental designs: pretest-posttest design. The sample was selected purposively from the whole population based on their reading comprehension scores. Forty six eighth graders were selected as the sample and equally divided into experimental and control groups. Pretest and posttest were given to both groups. Using paired sample statistics, the results of the experimental group showed that the students’ reading comprehension and writing achievement ? significantly improved. Furthermore, the result of the independent t-test showed that with mean difference of reading comprehension was 8.609, t value 11.111(p<0.05). Moreover, the mean difference of writing achievement was 6.8043, t value 10.478 (p<0.05). Keywords: Literature-based instruction, reading comprehension and writing achievement.
Exploring EFL Teacher Educators’ Goals in Teaching English Oral Communication Skill
Authors: Abid Abid 
Published: April 2021

The study reported in this article sought to explore teacher educators’ (TEs) perceived goals in teaching English oral communication in an English Education Program in Indonesia. Using a case study method, data for the present study were collected from all TEs teaching English speaking and listening subjects. A semi-structured interview protocols were carried out in English and Indonesian languages. All interview transcripts were transcribed verbatim and analysed using a thematic analysis method. The findings indicate that many of the TEs stress production when teaching oral communication. When asking about the purposes of teaching speaking or listening, they rarely mentioned any expectations that their PSTs would be independent and knowledgeable when dealing with oral communication breakdowns. Yet, this does not necessarily suggest any problems with TEs’ teaching practices and may instead indicate limited opportunities for PSTs to learn how to deal with oral communication breakdowns in the classroom. The findings of this study, thus, shed lights into current understanding of how teacher educators in Indonesia engage in the preparation of school English teachers’ candidates in the domain of oral communication skills.
Online Learning: Leading e-Learning at Higher Education
Authors: Ayu Mutiara 
Published: April 2021

In the 'Information Age' where the demand of knowledge raises, the students are expected to retrieve more information to support and develop their learning process. Some universities have progressively opened up to the opportunity of e-learning concept, and they are currently integrating e-learning in their teaching to accommodate the diverse need in learning and providing more interactive materials that allow easy access to information. E-learning has the potential to transform the way of teaching and studying across the board. It can develop standards, and improve involvement in learning. This cannot substitute teachers or lecturers role, but in addition to existing methods it can develop the quality and decrease the time spent. This paper aims at presenting an overview of the extent to which e-learning is used at higher education and explores e-learning from the perspective of students and teachers. It also briefly explains the current condition of e-learning that utilizes interactive technology to enhance the learning experience.Keywords: e-learning, higher education, technology
THE USE OF BIG CUBE GAME AS THE STRATEGY TO IMPROVE STUDENTS? VOCABULARY MASTERY
Authors: . Zaitun , Fitri Ananda Esa 
Published: April 2021

The purpose of this research is to convey Big Cube Game is effective in teaching vocabulary mastery. This research conducted in SMPN 3 Tangerang Selatan. The population of this research is seventh grade students, and the sample is 8.5 consists of 40 students. The method of this research is quantitative method and using pre ? experimental design. To collect the data, the researcher used pre ? test and post ? test that given to the students. The result score of the data indicated that, the total score of students in pre ? test were 2425 with the mean score was 60,62. The lowest score of pre ? test were 45 and the highest score were 90. The total score of students in post ? test were 3150 with the average were 78,75. The lowest score of post ? test were 65 and the highest score were 100. There is significance different from the result of pre ? test and post ? test score. The results of the pre-test and post-test were calculated using the manual statistically. And by using the t-test the results of t0 (4,47) are higher than the t-table at the significance level (p) = 0.05 (1,684). Thus it can be concluded that the Big Cube game has a significant strategy on the vocabulary mastery of students in class 8.5 at SMPN 3 Tangerang Selatan.
PENGEMBANGAN BAHAN AJAR PRAKTIKUM AKUNTANSI BERBASIS PEMBELAJARAN KOLABORATIF
Authors: Mardetini Edutivia , Fatimah Siti , Amrina Dian Eka 
Published: April 2021

Abstract
The problem formulated is how the validity, and practicality of practical colaborative teaching-based accounting practice. As for the purpose of this study is to describe the level of validity, and practicality of materials accounting practice course -based collaborative learning. This type of research is Research & Development (R & D) by Borg & Gall. Population in this study all students of economic education academic year 2017-2018. The sample of research that is students Indralaya class which take Accounting Practice course that amounts to 45 students. Data collection techniques used were questionnaires and tests of learning outcomes. With a validity test 91.67% obtained from the material experts and 90% of linguists who showed the results of both valid categorized vallidators. Then from the test practically obtained results stating that this resource is practically used to understand the material of accounting practice. Thus the development of cooperative learning materials based on collaborative learning accounting is valid and practical use in lectures activities.

Abstrak
Permasalahan yang dirumuskan adalah bagaimanakah validitas, dan kepratisan bahan ajar praktikum akuntansi berbasis pembelajaran kolaboratif. Adapun yang menjadi tujuan penelitian ini yaitu untuk mendeskripsikan tingkat validitas, dan kepraktisan bahan ajar pratikum akuntansi berbasis pembelajaran kolaboratif. Jenis penelitian ini yaitu penelitian Research & Development (R&D) oleh Borg & Gall. Populasi dalam penelitian ini seluruh mahasiswa pendidikan ekonomi semester ganjil tahun akademik 2017-2018. Dengan sampel penelitian yaitu mahasiswa yang mengikuti mata kuliah Praktikum Akuntansi kelas Indralaya yang berjumlah 45 mahasiswa. Teknik pengumpulan data yang digunakan yaitu angket. Dengan uji kevalidan diperoleh 91,67% dari ahli materi dan 90% dari ahli bahasa yang menunjukkan hasil kedua vallidator terkategori valid. Kemudian dari uji kepaktisan diperoleh hasil yang menyatakan bahwa bahan ajar ini praktis digunakan untuk memahami materi praktikum akuntansi. Dengan demikian pengembangan bahan ajar praktikum akuntansi berbasis pembelajaran kolaboratif bersifat valid, dan praktis untuk digunakan dalam kegiatan perkuliahan.
PENGARUH MODEL PEMBELAJARAN COOP-COOP TERHADAP MINAT BELAJAR PESERTA DIDIK PADA MATA PELAJARAN EKONOMI DI SMA NEGERI 19 PALEMBANG
Authors: Ambarwati Yuli , Koryati Dewi , Deskoni Deskoni 
Published: April 2021

Abstract
This study aims to test the influence of Coop-Coop Model on Student Learning Interest in Economic Subject in SMA Negeri 19 Palembang. The research problem is "is there any influence of Coop-Coop model on the interest of learners on economic subjects in SMA Negeri 19 Palembang". This research is an experimental research, which uses Pre-experimental design design, with the form of One Group pretest posttest. The population in this research is all class XI IPS in SMA Negeri 19 Palembang which amounted to 174 students. The sample used cluster random sampling, so selected XI IPS 2class of 34 students as experimental class.Data collection techniques used are observations and questionnaires. Observation data collection techniques obtained from teacher observation and interest of learners at the time of learning took place. Hypothesis testing using parametric stasis is product moment coller obtained r = 1. With very strong interpretation, Coefficient of Determination of 100% and t-test obtained value t count ? t tabel = 55,58>1,67 so Ha received Ho rejected. So it can be concluded there is influence of Coop-Coop model on the interest of learners on the subjects Economic at SMA Negeri 19 Palembang.

Abstrak
Penelitian ini bertujuan untuk menguji Pengaruh Model Coop-Coop terhadap Minat Belajar Peserta Didik pada Mata Pelajaran Ekonomi di SMA Negeri 19 Palembang. Adapun permasalahan penelitia yaitu “adakah pengaruh model Coop-Coop terhadap minat belajar peserta didik pada mata pelajaran ekonomi di SMA Negeri 19 Palembang”. Penelitian ini merupakan penelitian eksperimen, yang menggunakan desain Pre-experimental design, dengan bentuk One Group pretest posttest.Populasi dalam penelitian ini adalah seluruh kelas XI IPS di SMA Negeri 19 Palembang yang berjumlah 174 peserta didik. Sampel penelitian menggunakan cluster random sampling, sehingga terpilih kelas XI IPS 2 yang berjumlah 34 peserta didik sebagai kelas eksperimen. Teknik pengumpulan data yang digunakan yaitu observasi dan angket.Teknik pengumpulan data observasi diperoleh dari observasi guru dan minat peserta didik pada saat pembelajaran berlangsung.Pengujian Hipotesis menggunakan stasistik parametris yaitu kolerasi product moment diperoleh r = 1. Dengan interprestasi sangat kuat, Koefisien Dideterminan sebesar 100 % dan uji-t diperoleh nilai =55,58 1,67 jadi Ha diterima Ho ditolak. Maka dapat disimpulkan ada pengaruh model Coop-Coop terhadap minat belajar peserta didik pada mata pelajaran Ekonomi di SMA Negeri 19 Palembang.
PENGEMBANGAN PROGRAM MYOB PADA PEMBELAJARAN KOMPUTER AKUNTANSI DI PROGRAM STUDI PENDIDIKAN EKONOMI FKIP UNIVERSITAS SRIWIJAYA
Authors: Deskoni Deskoni , AR Rusmin , Firmansyah Firmansyah 
Published: April 2021

Abstract
This research is aimed to produce MYOB learning materials in accounting computer learning which was valid, practice, and having the potential effects toward the learning achievement. This research prosedure using Rowntree Model which had three stages, which consists of planning, developing, and evaluating. The data validity was done through the expert evaluation stage with the percentage result from the media expert and the material expert show the results of 80% with a valid category used the validation sheet. The data practicality was done through the one-to-one evaluation with the percentage results of 87,5% and small group evaluation with the percentage results of 92,44% in the very practically category through questionnaire. The data potential effects was done through the field test stage using pretest shows the results of 45%. The data posttest shows the results of 85%. It shows an increasing in learning achievement of 40% and it can be concluded that the MYOB learning materials in accounting computer learning which was valid, practice, and having the potential effects toward the learning achievement.

Abstrak
Penelitian ini bertujuan untuk menghasilkan bahan ajar MYOB untuk pembelajaran komputer akuntansi yang valid, praktis, serta berefek potensial terhadap hasil belajar mahasiswa. Penelitian ini menggunakan model Rowntree yakni tahap perencanaan, tahap pengembangan, dan tahap evaluasi. Untuk melihat validitas, dilakukan pada tahap evaluasi ahli dengan hasil persentase dari ahli media dan ahli materi sebesar 80% dengan kategori valid melalui lembar validasi. Untuk melihat praktikalitas, dilakukan tahap evaluasi one-to-one dengan hasil penilaian sebesar 87,5% dan tahap evaluasi small group dengan hasil penilaian sebesar 92,44% dengan kategori sangat praktis melalui angket. Untuk melihat efek potensial, dilakukan pada tahap field test dengan menggunakan tes hasil belajar awal (pre-test) diperoleh hasil persentase sebesar 45% dan hasil belajar akhir (post-test) diperoleh hasil sebesar 85%, terjadi peningkatan hasil belajar yakni sebesar 40% dan disimpulkan bahan ajar MYOB berefek potensial terhadap hasil belajar mahasiswa.