bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced catalysis through structurally modified hybrid 2-D boron nitride nanosheets comprising of complexed 2-hydroxy-4-methoxybenzophenone motif
Authors: Rana Pooja , Dixit Ranjana , Sharma Shivani , Dutta Sriparna , Yadav Sneha , Sharma Aditi , Kaushik Bhawna , Rana Pooja , Adholeya Alok , Sharma Rakesh K. 
Published: December 2021

AbstractTuning the structural architecture of the pristine two dimensional hexagonal boron nitride (h-BN) nanosheets through rational surface engineering have proven advantageous in the fabrication of competent catalytic materials. Inspired by the performance of h-BN based nanomaterials in expediting key organic transformations, we channelized our research efforts towards engineering the inherent surface properties of the exclusively stacked h-BN nanosheets through the incorporation of a novel competent copper complex of a bidentate chelating ligand 2-hydroxy-4-methoxybenzophenone (BP). Delightfully, this hybrid nanomaterial worked exceptionally well in boosting the [3 + 2] cycloaddition reaction of azide and nitriles, providing a facile access to a diverse variety of highly bioactive tetrazole motifs. A deep insight into the morphology of the covalently crafted h-BN signified the structural integrity of the exfoliated h-BN@OH nanosheets that exhibited lamellar like structures possessing smooth edges and flat surface. This interesting morphology could also be envisioned to augment the catalysis by allowing the desired surface area for the reactants and thus tailoring their activity. The work paves the way towards rational design of h-BN based nanomaterials and adjusting their catalytic potential by the use of suitable complexes for promoting sustainable catalysis, especially in view of the fact that till date only a very few h-BN nanosheets based catalysts have been devised.
Making nanostructured materials from maize, milk and malacostraca
Authors: Suriyanarayanan Subramanian , Nicholls Ian A. 
Published: December 2021

AbstractNano-structured materials are used in electronics, diagnostics, therapeutics, smart packaging, energy management and textiles, areas critical for society and quality of life. However, their fabrication often places high demands on limited natural resources. Accordingly, renewable sources for the feedstocks used in their production are highly desirable. We demonstrate the use of readily available biopolymers derived from maize (zein), milk (casein) and malacostraca (crab-shell derived chitin) in conjunction with sacrificial templates, self-assembled monodisperse latex beads and anodized aluminium membranes, for producing robust surfaces coated with highly regular hyperporous networks or wire-like morphological features, respectively. The utility of this facile strategy for nano-structuring of biopolymers was demonstrated in a surface based-sensing application, where biotin-selective binding sites were generated in the zein-based nano-structured hyperporous network.
Impact of limb amputation and cisplatin chemotherapy on metastatic progression in mouse models of osteosarcoma
Authors: Ren L. , Huang S. , Beck J. , LeBlanc Amy K. 
Published: December 2021

AbstractDevelopment of animal models that accurately recapitulate human cancer is an ongoing challenge. This is particularly relevant in the study of osteosarcoma (OS), a highly malignant bone tumor diagnosed in approximately 1000 pediatric/adolescent patients each year. Metastasis is the leading cause of patient death underscoring the need for relevant animal models of metastatic OS. In this study, we describe how existing OS mouse models can be interrogated in a time-course context to determine the kinetics of spontaneous metastasis from an orthotopically implanted primary tumor. We evaluated four highly metastatic OS cell lines (3 human, 1 mouse) to establish a timeline for metastatic progression in immune deficient NSG mice. To discern the effects of therapy on tumor development and metastasis in these models, we investigated cisplatin therapy and surgical limb amputation at early and late timepoints. These data help define the appropriate observational periods for studies of metastatic progression in OS and further our understanding of existing mouse models. Efforts to advance the study of metastatic OS are critical for facilitating the identification of novel therapeutics and for improving patient survival.
Three-dimensional imaging mass cytometry for highly multiplexed molecular and cellular mapping of tissues and the tumor microenvironment
Authors: Kuett Laura , Catena Raúl , Özcan Alaz , Plüss Alex ,   Cancer Grand Challenges IMAXT Consortium, Ali H. R. , Sa’d M. Al , Alon S. , Aparicio S. , Battistoni G. , Balasubramanian S. , Becker R. , Bodenmiller B. , Boyden E. S. , Bressan D. , Bruna A. , Burger Marcel , Caldas C. , Callari M. , Cannell I. G. , Casbolt H. , Chornay N. , Cui Y. , Dariush A. , Dinh K. , Emenari A. , Eyal-Lubling Y. , Fan J. , Fatemi A. , Fisher E. , González-Solares E. A. , González-Fernández C. , Goodwin D. , Greenwood W. , Grimaldi F. , Hannon G. J. , Harris S. , Jauset C. , Joyce J. A. , Karagiannis E. D. , Kovačević T. , Kuett L. , Kunes R. , Yoldaş A. Küpcü , Lai D. , Laks E. , Lee H. , Lee M. , Lerda G. , Li Y. , McPherson A. , Millar N. , Mulvey C. M. , Nugent I. , O’Flanagan C. H. , Paez-Ribes M. , Pearsall I. , Qosaj F. , Roth A. J. , Rueda O. M. , Ruiz T. , Sawicka K. , Sepúlveda L. A. , Shah S. P. , Shea A. , Sinha A. , Smith A. , Tavaré S. , Tietscher S. , Vázquez-García I. , Vogl S. L. , Walton N. A. , Wassie A. T. , Watson S. S. , Weselak J. , Wild S. A. , Williams E. , Windhager J. , Xia C. , Zheng P. , Zhuang X. , Schraml Peter , Moch Holger , de Souza Natalie , Bodenmiller Bernd 
Published: December 2021

AbstractA holistic understanding of tissue and organ structure and function requires the detection of molecular constituents in their original three-dimensional (3D) context. Imaging mass cytometry (IMC) enables simultaneous detection of up to 40 antigens and transcripts using metal-tagged antibodies but has so far been restricted to two-dimensional imaging. Here we report the development of 3D IMC for multiplexed 3D tissue analysis at single-cell resolution and demonstrate the utility of the technology by analysis of human breast cancer samples. The resulting 3D models reveal cellular and microenvironmental heterogeneity and cell-level tissue organization not detectable in two dimensions. 3D IMC will prove powerful in the study of phenomena occurring in 3D space such as tumor cell invasion and is expected to provide invaluable insights into cellular microenvironments and tissue architecture.
Green ammonia synthesis using CeO2/RuO2 nanolayers on vertical graphene catalyst via electrochemical route in alkaline electrolyte
Authors: Ju HyungKuk , Seo Dong Han , Chung Sunki , Mao Xin , An Byeong-Seon , Musameh Mustafa , Gengenbach Thomas R. , Shon Hokyong , Du Aijun , Bendavid Avi , Ostrikov Kostya (Ken) , Yoon Hyung Chul , Lee Jaeyoung , Giddey Sarbjit 
Published: December 2021

The electrochemical synthesis of ammonia using nanolayered catalyst of RuO2 and CeO2 on a 3D-Graphene support at an ambient condition, demonstrates excellent NRR activity with long-term stability.
Research on optimal scheduling decision of multi‐microgrids based on cloud energy storage
Authors: Wang Yujie , Yang Junjie , Jiang Wei , Sui Zhicheng , Chen Ting 
Published: December 2021

AbstractIn microgrids, energy storage systems (ESS) can mitigate the intermittency and uncertainty associated with large amounts of renewable energy connected to the grid. Cloud energy storage (CES) is a solution proposed by scholars over the last two years. It provides energy storage and trading services that can alleviate high investment costs and small‐scale wind and light abandonment problems. However, large‐scale energy mutualisation and fine scheduling of energy become significant challenges for further development. This study proposes a CES scheduling architecture based on multi‐microgrids. CES extends the scope of power trading from a single microgrid to multi‐microgrids, with the microgrid capable of interacting with neighbouring microgrids for power and reducing the transmission pressure on the larger grid. In addition, this study defines the game strategy for power trading between cloud storage operators, considering the reduction in electricity costs due to dishonest behaviour by users. The simulation results indicate that the proposed dispatching architecture and strategy can effectively improve the consumption rate of new energy sources, mitigate grid fluctuations, and further reduce electricity costs for users while also being resilient to dishonest user behaviour.
J-PLUS: Support vector machine applied to STAR-GALAXY-QSO classification
Authors: Wang C. , Bai Y. , López-Sanjuan C. , Yuan H. , Wang S. , Liu J. , Sobral D. , Baqui P. O. , Martín E. L. , Andres Galarza C. , Alcaniz J. , Angulo R. E. , Cenarro A. J. , Cristóbal-Hornillos D. , Dupke R. A. , Ederoclite A. , Hernández-Monteagudo C. , Marín-Franch A. , Moles M. , Sodré L. , Vázquez Ramió H. , Varela J. 
Published: December 2021

Context.In modern astronomy, machine learning has proved to be efficient and effective in mining big data from the newest telescopes.Aims.In this study, we construct a supervised machine-learning algorithm to classify the objects in the Javalambre Photometric Local Universe Survey first data release (J-PLUS DR1).Methods.The sample set is featured with 12-waveband photometry and labeled with spectrum-based catalogs, including Sloan Digital Sky Survey spectroscopic data, the Large Sky Area Multi-Object Fiber Spectroscopic Telescope, and VERONCAT – the Veron Catalog of Quasars & AGN. The performance of the classifier is presented with the applications of blind test validations based on RAdial Velocity Extension, theKeplerInput Catalog, the Two Micron All Sky Survey Redshift Survey, and the UV-bright Quasar Survey. A new algorithm was applied to constrain the potential extrapolation that could decrease the performance of the machine-learning classifier.Results.The accuracies of the classifier are 96.5% in the blind test and 97.0% in training cross-validation. TheF1-scores for each class are presented to show the balance between the precision and the recall of the classifier. We also discuss different methods to constrain the potential extrapolation.
Cross-site investigation on head-related and headphone transfer functions: variabilities in relation to loudness balancing
Authors: Kohnen Michael , Denk Florian , Llorca-Bofi Josep , Kollmeier Birger , Vorländer Michael 
Published: December 2021

Headphone transfer function (HpTF) and head-related transfer function (HRTF) measurements are crucial in acoustic science and in binaural virtual acoustic applications. Yet, their measurement set-up, procedure or post-processing is different for nearly every lab, especially for the HRTF measurements. To compare findings between different labs, these measurement deviations have to be quantified alongside with their influence on perceptual aspects. In the scope of a cross-site investigation on loudness balancing between headphone and loudspeaker listening, a set of HpTFs with three different headphones (open, closed, insert earphones) and HRTF close to the eardrum were measured in 14 participants travelling to two different measurement sites at Aachen and Oldenburg. Though set-ups for measuring the HRTF are very different between sites, the gathered HRTFs are quite consistent across them. For the measured HpTFs, across sites the open headphones consistently yield a slightly lower variability in the range from 70 to 5000 Hz than the closed one while the insert earphones exhibit much higher variabilities and a limited range of reproducible results. The difference in loudness balancing across labs could well be predicted by site-specific systematic differences in HpTFs with the exception of 1 kHz narrowband stimulus. This clearly indicates the limits in comparability of HpTFs and loudness balancing across labs and the importance of using headphones with high repeatability like the open ones used in this investigation.
Tone detection thresholds in interaurally delayed noise of different bandwidths
Authors: Dietz Mathias , Encke Jörg , Bracklo Kristin I , Ewert Stephan D 
Published: December 2021

Differences between the interaural phase of a noise and a target tone improve detection thresholds. The maximum masking release is obtained for detecting an antiphasic tone (Sπ) in diotic noise (N0). It has been shown in several studies that this beneﬁt gradually declines as an interaural time delay (ITD) is applied to the noise. This decline has been attributed to the reduced interaural coherence of the noise. Here, we report detection thresholds for a 500 Hz tone in masking noise with ITDs up to 8 ms and bandwidths from 25 to 1000 Hz. Reducing the noise bandwidth from 100 to 50 and 25 Hz increased the masking release for 8-ms ITD, as expected for increasing temporal coherence with decreasing bandwidth. For bandwidths of 100–1000 Hz no significant difference in masking release was observed. Detection thresholds with these wider-band noises had an ITD dependence that is fully described by the temporal coherence imposed by the typical monaurally determined auditory-filter bandwidth. A binaural model based on interaural phase-difference fluctuations accounts for the data without using delay lines.
Chondrosarcoma of the Nasal Septum—A Rare Subsite: Case Report with Review of Literature
Authors: Gupta Nidhi , Pandey Awadhesh Kumar , Dimri Kislay , Singhal Surinder K , Rathee Neeraj , Naryal Shalu , Sharma Pooja , Upadhyay Amitabh Kumar 
Published: December 2021

AbstractChondrosarcomas are the second most common primary malignant bone tumors. Head and neck chondrosarcomas constitute less than 10% of these tumors, rarely arising from the nasal septum. These are locally aggressive malignant tumors arising from the cartilaginous framework of the nasal septum. Rarity of the tumor coupled with nonspecific symptoms makes it a diagnostic dilemma. Diagnosis requires endoscopy, radiology, and final histopathology for confirmation. Treatment is mainly surgical, requiring complete surgical excision with clear margins. Radiation has a role in unresectable tumors or for tumors with positive margins after surgery. Survival depends on the grade of tumor that predicts the metastatic potential of the tumor. We present a rare case of chondrosarcoma arising from the nasal septum in a 29-year-old young female presenting with complaints of nasal obstruction. Computed tomography was suggestive of a calcified cartilaginous tumor arising from the nasal septum. Endoscopic excision was done and postoperative histopathology showed grade II chondrosarcoma with clear margins. No adjuvant treatment was given to our patient and 2 years post-excision patient is disease free.To conclude, chondrosarcoma of the nasal septum is a rare tumor, with nonspecific symptoms. Surgery with clear margins remains the treatment of choice. Prognosis depends on the extent of tumor at presentation, resection margins, and grade of tumor.
3Shape Digital Design Software in Splints Creation—A Pilot Study
Authors: Shopova Dobromira , Yordanova Miroslava , Yordanova Svetlana 
Published: December 2021

Abstract
Objectives Digital technologies have widened their horizons into the world of dental medicine and now further expanding to cover all branches. This new modern technology replaces traditional laboratory techniques allowing effective patient care. Patients who suffer from bruxism—the act of involuntary habitual grinding of teeth—have widely been benefited by splint treatments. The aim of this article is to display the variety of occlusal splints that can be created by the 3Shape Digital Design Software and their application in specific clinical situations.
Materials and Methods Six variations in the splints were created digitally—three with uncombined designs and the remaining three with a combination of two of the main options available. During this study, 36 splints were made for patients aged 24 to 55 inclusively.
Results The largest number of splints according to the clinical picture were made of “raise to antagonist cusp tips” (14 pieces) and the remaining were of combined type “raise to antagonist cusp tips + raise to antagonist plane” (12 pieces). There thickness was within the range of 1.5 and 5 mm.
Conclusion 3Shape Digital Design Software—Splint Studio is a suitable system for designing and creating occlusal splints with respect to certain clinical situations. It is possible to combine the three main types in a separate section of the dental arch according to the case.
Frameshift Variant in ARID2 in a Chilean Individual with Coffin–Siris Syndrome Phenotype
Authors: Martin Merlez Fernanda , González Zalazar María , Castillo Taucher Silvia 
Published: December 2021

AbstractCoffin–Siris syndrome (CSS) is one of the several causes of intellectual disability (ID) and, since its first description, has posed diagnostic challenges given its variability and phenotypic overlap with other alterations of chromatin-remodeling-associated syndromes. It is genetically heterogeneous, and causative mutations are detected in less than 70% of cases. The different subtypes of the syndrome described to date are caused by mutations in genes that encode subunits of the SWI/SNF chromatin-remodeling complex, which plays an essential role in the regulation of gene expression during embryogenesis. Whole exome sequencing (WES) has allowed the identification of pathogenic mutations in these genes, including ARID2. ARID2 is one of the primary components of the SWI/SNF complex and has been associated with ID and phenotypes similar to CSS for the first time in 2015. Fifteen published case reports have identified loss-of-function mutations, suggesting that the underlying pathogenic disease mechanism is haploinsufficiency of ARID2.We herein presented the case of an 8-year-old Chilean girl with clinical suspicion of CSS, in whom a novel frameshift variant in ARID2 was identified by WES. She was the first reported case in Latin America to our knowledge and her phenotype displays the main clinical features suggestive of CSS described in other patients with ARID2 variants. However, she did not present behavioral abnormalities, a characteristic frequently reported in the majority of patients with ARID2 variants, and also had some features, such as sparse scalp hair, which is frequently reported as a manifestation of CSS, but is uncommon in this new group of patients.
Frozen Elephant Trunk Technique to Treat Extensive Thoracic Aortic Mural Thrombus
Authors: Panfilov Dmitri S. , Kozlov Boris N. 
Published: December 2021

AbstractWe describe a case report of a 63-year-old man who presented with chronic left-hand weakness and the absence of a pulse in the left arm. Thoracoabdominal computed tomography (CT) revealed an extensive thoracic aortic mural thrombus. Initial anticoagulation therapy did not provide a positive result, so the patient was referred for surgery. Hybrid aortic arch surgery using the frozen elephant trunk technique was performed with excellent early outcomes. A CT performed in the early postoperative period showed that the thrombus was completely excluded from the aortic lumen by the hybrid graft. No thrombus dislodgment was detected. No thrombus recurrence was observed during 19 months of follow-up.
Clinical and Functional Outcomes of Total Knee Arthroplasty in Sarcopenia: A Case–Control Retrospective Cohort Study
Authors: He Zili , Cai Jie , Wang Xingyu , Lu Di 
Published: December 2021

Abstract
Background The aim of the study was to investigate the relationship between sarcopenia and both clinical and functional outcome scores following total knee arthroplasty (TKA) performed for patients over 65 years of age.
Methods We assessed patient demographics, preoperative health status, postoperative Knee Society Clinical (KSS-C) and Function (KSS-F) subscores, and perioperative complications for 180 patients with sarcopenia and 345 comparatively healthy patients at a mean of 12.0 months after surgery. Multivariate logistic regression analysis was performed to define whether sarcopenia was an independent risk factor for lower KSS-F and KSS-C subscores and peroperative complication rates. Patients with sarcopenia had lower mean body mass index, preoperative albumin, and preoperative hemoglobin levels (p < 0.01).
Results Compared with the healthy control group, patients with sarcopenia had lower KSS-C (83.0 vs. 88.2, p < 0.01) and KSS-F (79.2 vs. 86.1, p < 0.01) subscores and increased postoperative complication rates (14.1% vs. 4.1%, p < 0.01).
Conclusion Patients with sarcopenia present with generally poorer preoperative health and this appears to be associated with lower patient-reported clinical and functional outcome scores. Complication rates were higher among patients with sarcopenia who were still determined to have adequate health status to support TKA. Most complications were limited and could be managed with supportive treatment.
COVID-19 Infection Manifesting with Lumbar Spondylodiscitis Complicating With Psoas Abscess without Pneumonia
Authors: Erok Berrin , Kıbıcı Kenan 
Published: December 2021

AbstractExtrapulmonary manifestations of COVID-19 (Coronavirus disease 2019) are increasingly recognized. Secondary spinal infections are dangerous complications reported in a few cases in the literature. However, to our knowledge, there is no reported case of a severe spondylodiscitis (SD) complicated with a large psoas abscess in a COVID-19 patient. We would like to report a 43-year-old male patient living in central Anatolia and dealing with farming who presented to the hospital with a complaint of severe back pain. The patient who was given oral treatment with analgesic, anti-inflammatory, and myorelaxant agents was readmitted with increased complaints. His nasopharyngeal swab was positive for COVID-19 without pneumonia on chest computed tomography (CT). He spent the quarantine and treatment period at home but was admitted to our outpatient clinic with a wheelchair with increased complaints and right leg pain preventing daily activities. The control nasopharyngeal swab was negative for COVID-19 but further increase in C-reactive protein (CRP) (152,8 mg/L) and creatine kinase (CK) level (549 IU/L) were revealed. Lumbar magnetic resonance imaging (MRI) showed SD in the L3-L4 level along with right-sided prevertebral inflammatory soft tissue and a large right psoas muscle abscess. Pyogenic lumbar SD complicated with the right psoas abscess in the setting of COVID-19 was considered and antibacterial treatment was started following hospitalization. On the same day, percutaneous aspiration from the psoas abscess under CT guidance was performed and revealed no growth in the culture. After 3 weeks, follow-up MRI showed worsening of all the bone, soft tissue and disc findings. Myalgia is a common manifestation in viral infections, which was also demonstrated in COVID-19 patients, with possible increase in muscle enzymes. Secondary spinal infections and its soft-tissue complications should be considered in the management of COVID-19 patients with neuromuscular symptoms, and detailed neurological and neurosurgical evaluation should be performed in order to avoid progression and permanent damage.