bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic switch of immunity and antitumor effects of metformin in rat spontaneous esophageal carcinogenesis
Authors: Takei Ryohei , Miyashita Tomoharu , Takada Satoshi , Tajima Hidehiro , Ninomiya Itasu , Takamura Hiroyuki , Fushida Sachio , Harashima Ai , Munesue Seiichi , Yagi Shintaro , Inaki Noriyuki , Ohta Tetsuo , Yamamoto Yasuhiko 
Published: August 2021

AbstractChronic inflammation contributes to tumor development by creating a local microenvironment that facilitates neoplastic transformation and potentiates the progression of cancer. Esophageal cancer (EC) is an inflammation-associated malignancy with a poor prognosis. The nature of the switch between chronic inflammation of the esophagus and EC-related immunological changes remains unclear. Here, we examined the dynamic alterations of immune cells at different stages of chronic esophagitis, Barrett’s esophagus (BE) and EC using an esophageal spontaneous carcinogenesis rat model. We also investigated the anticancer effects of metformin. To stimulate EC carcinogenesis, chronic gastroduodenal reflux esophagitis via esophagojejunostomy was induced in 120 rats in metformin-treated and non-treated (control) groups. After 40 weeks, BE and EC developed in 96.7% and 63.3% of the control group, and in 66.7% and 23.3% of the metformin-treated group, respectively. Flow cytometric analysis demonstrated that the balance of M1/M2-polarized or phospho-Stat3-positive macrophages, regulatory T, cytotoxic T, natural killer (NK), NK T cells, and Th17 T cells was dynamically changed at each stage of the disease and were resolved by metformin treatment. These findings clarify the immunity in esophageal carcinogenesis and suggest that metformin could suppress this disease by improving the immunosuppressive tumor microenvironment and immune evasion.
Is There a Role for Topical Swallowed Steroids upon Emergency Room Admission for Suspected Food Bolus Obstruction in Eosinophilic Esophagitis?
Authors: Schreiner Philipp , Greuter Thomas , Tatu Aurora , Keller Dagmar I. , Straumann Alex , Biedermann Luc 
Published: August 2021

AbstractSince most pharmacological treatments in case of esophageal food impaction (EFI) are unsuccessful, an endoscopy is usually required to resolve EFI. We present the first results of a budesonide orodispersible tablet (BOT) as a medical treatment option before endoscopy. We evaluated all patients with a suspected EFI to receive BOT before emergent endoscopy at a tertiary hospital between March 2019 and June 2020. A total of eight patients received BOT before endoscopy. Mean age was 50.1 years and 87.5% were male. In 38% (3/8) of patients the EFI resolved without endoscopic intervention. No adverse events occurred. After endoscopy, a diagnosis of EoE was established in 75%. This case series demonstrate the potential of BOT as medical rescue therapy in case of EFI.
Clinical effectiveness of gasless laparoscopic surgery for abdominal conditions: systematic review and meta-analysis
Authors: Aruparayil N. , Bolton W. , Mishra A. , Bains L. , Gnanaraj J. , King R. , Ensor T. , King N. , Jayne D. , Shinkins B. 
Published: August 2021

Abstract
Background
In high-income countries, laparoscopic surgery is the preferred approach for many abdominal conditions. Conventional laparoscopy is a complex intervention that is challenging to adopt and implement in low resource settings. This systematic review and meta-analysis evaluate the clinical effectiveness of gasless laparoscopy compared to conventional laparoscopy with CO2 pneumoperitoneum and open surgery for general surgery and gynaecological procedures.

Methods
A search of the MEDLINE, EMBASE, Global Health, AJOL databases and Cochrane Library was performed from inception to January 2021. All randomised (RCTs) and comparative cohort (non-RCTs) studies comparing gasless laparoscopy with open surgery or conventional laparoscopy were included. The primary outcomes were mortality, conversion rates and intraoperative complications. Secondary outcomes: operative times and length of stay. The inverse variance random-effects model was used to synthesise data.

Results
63 studies were included: 41 RCTs and 22 non-RCTs (3,620 patients). No procedure-related deaths were reported in the studies. For gasless vs conventional laparoscopy there was no difference in intraoperative complications for general RR 1.04 [CI 0.45–2.40] or gynaecological surgery RR 0.66 [0.14–3.13]. In the gasless laparoscopy group, the conversion rates for gynaecological surgery were high RR 11.72 [CI 2.26–60.87] when compared to conventional laparoscopy. For gasless vs open surgery, the operative times were longer for gasless surgery in general surgery RCT group MD (mean difference) 10 [CI 0.64, 19.36], but significantly shorter in the gynaecology RCT group MD − 18.74 [CI − 29.23, − 8.26]. For gasless laparoscopy vs open surgery non-RCT, the length of stay was shorter for gasless laparoscopy in general surgery MD − 3.94 [CI − 5.93, − 1.95] and gynaecology MD − 1.75 [CI − 2.64, − 0.86]. Overall GRADE assessment for RCTs and Non-RCTs was very low.

Conclusion
Gasless laparoscopy has advantages for selective general and gynaecological procedures and may have a vital role to play in low resource settings.
Current experimental disease-modifying therapeutics for multiple system atrophy
Authors: Lemos Miguel , Wenning Gregor K. , Stefanova Nadia 
Published: August 2021

AbstractMultiple system atrophy (MSA) is a challenging neurodegenerative disorder with a difficult and often inaccurate early diagnosis, still lacking effective treatment. It is characterized by a highly variable clinical presentation with parkinsonism, cerebellar ataxia, autonomic dysfunction, and pyramidal signs, with a rapid progression and an aggressive clinical course. The definite MSA diagnosis is only possible post-mortem, when the presence of distinctive oligodendroglial cytoplasmic inclusions (GCIs), mainly composed of misfolded and aggregated α-Synuclein (α-Syn) is demonstrated. The process of α-Syn accumulation and aggregation within oligodendrocytes is accepted one of the main pathological events underlying MSA. However, MSA is considered a multifactorial disorder with multiple pathogenic events acting together including neuroinflammation, oxidative stress, and disrupted neurotrophic support, among others. The discussed here treatment approaches are based on our current understanding of the pathogenesis of MSA and the results of preclinical and clinical therapeutic studies conducted over the last 2 decades. We summarize leading disease-modifying approaches for MSA including targeting α-Syn pathology, modulation of neuroinflammation, and enhancement of neuroprotection. In conclusion, we outline some challenges related to the need to overcome the gap in translation between preclinical and clinical studies towards a successful disease modification in MSA.
Spinocerebellar ataxias (SCAs) caused by common mutations
Authors: Müller Ulrich 
Published: August 2021

AbstractThe term SCA refers to a phenotypically and genetically heterogeneous group of autosomal dominant spinocerebellar ataxias. Phenotypically they present as gait ataxia frequently in combination with dysarthria and oculomotor problems. Additional signs and symptoms are common and can include various pyramidal and extrapyramidal signs and intellectual impairment. Genetic causes of SCAs are either repeat expansions within disease genes or common mutations (point mutations, deletions, insertions etc.). Frequently the two types of mutations cause indistinguishable phenotypes (locus heterogeneity). This article focuses on SCAs caused by common mutations. It describes phenotype and genotype of the presently 27 types known and discusses the molecular pathogenesis in those 21 types where the disease gene has been identified. Apart from the dominant types, the article also summarizes findings in a variant caused by mutations in a mitochondrial gene. Possible common disease mechanisms are considered based on findings in the various SCAs described.
Theranostic applications of optical coherence tomography in neurosurgery?
Authors: Hartmann Karl , Stein Klaus-Peter , Neyazi Belal , Sandalcioglu I. Erol 
Published: August 2021

Abstract
In light of our own experiences, we value the existing literature to critically point out possible “near” future applications of optical coherence tomography (OCT) as an intraoperative neurosurgical guidance tool. “Pub Med”, “Cochrane Library”, “Crossref Metadata Search”, and “IEEE Xplore” databases as well as the search engine “Google Scholar” were screened for “optical coherence tomography + neurosurgery”, “optical coherence tomography + intraoperative imaging + neurosurgery”, and “microscope integrated optical coherence tomography + neurosurgery”. n = 51 articles related to the use of OCT as an imaging technique in the field of neurosurgery or neurosurgical research. n = 7 articles documented the intraoperative use of OCT in patients. n = 4 articles documented the use of microscope-integrated optical coherence tomography as a neurosurgical guidance tool. The Results demonstrate that OCT is the first imaging technique to study microanatomy in vivo. Postoperative analysis of intraoperative scans holds promise to enrich our physiological and pathophysiological understanding of the human brain. No data exists to prove that OCT-guided surgery minimizes perioperative morbidity or extends tumor resection. But results suggest that regular use of microscope-integrated OCT could increase security during certain critical microsurgical steps like, e.g., dural dissection at cavernous sinus, transtentorial approaches, or aneurysm clip placement. Endoscopy integration could aid surgery in regions which are not yet accessible to real-time imaging modalities like the ventricles or hypophysis. Theranostic instruments which combine OCT with laser ablation might gain importance in the emerging field of minimal invasive tumor surgery. OCT depicts vessel wall layers and its pathologies uniquely. Doppler OCT could further visualize blood flow in parallel. These abilities shed light on promising future applications in the field of vascular neurosurgery.
Optimization and assessment of a sequential extraction procedure for calcium carbonate rocks
Authors: Scheplitz Janin , Koopmann Sarah , Fröllje Henning , Pichler Thomas 
Published: August 2021

AbstractSequential extraction analyses are widely used for the determination of element speciation in sediments and soils. Typical sequential extraction protocols were developed to extract from low-carbonate samples and therefore are not necessarily suitable for high-carbonate samples. In this study, we tested increased reagent to sample ratios to adjust an existing sequential extraction procedure to analyze high-CaCO3 samples with concentrations ranging from 70 to above 90 %. Complete dissolution of the CaCO3 phase, and a higher extraction efficiency of manganese associated with the carbonate phase, was achieved when using four times the original reagent to sample ratio in the 2nd extraction step. This increase of reagent did not compromise the extraction of subsequent phases as shown by unaffected Fe concentrations in a low-carbonate sample. Hence, an essential outcome was that increasing the solution to sample ratio did not lead to the dissolution of other sedimentary phases, such as hydrous and crystalline iron oxides or sulfides. Thus, compared to other extraction protocols that use a lower reagent to sample ratio in the carbonate dissolution step, the new protocol allowed the complete extraction of oxide and sulfide phases in the following extraction steps. Furthermore, the study demonstrated the benefit of replacing Na-acetate with NH4-acetate to extract exchangeable ions and carbonates. We observed increased intensities for several analytes, i.e., trace metals such as Mo and As, due to less suppression of the analyte signal by NH4-acetate than by Na-acetate during analysis by inductively coupled plasma optical emission spectrometry (ICP-OES).
Ignorance implicatures of modified numerals
Authors: Cremers Alexandre , Coppock Liz , Dotlačil Jakub , Roelofsen Floris 
Published: August 2021

AbstractModified numerals, such as at least three and more than five, are known to sometimes give rise to ignorance inferences. However, there is disagreement in the literature regarding the nature of these inferences, their context dependence, and differences between at least and more than. We present a series of experiments which sheds new light on these issues. Our results show that (a) the ignorance inferences of at least are more robust than those of more than, (b) the presence and strength of the ignorance inferences triggered by both at least and more than depends on the question under discussion (QUD), and (c) whether ignorance inferences are detected in a given experimental setting depends partly on the task that participants are asked to perform (e.g., an acceptability task versus an inference task). We offer an Optimality Theoretic account of these findings. In particular, the task effect is captured by assuming that in performing an acceptability task, participants take the speaker’s perspective in order to determine whether an expression is optimal given a certain epistemic state, while in performing an inference task they take the addressee’s perspective in order to determine what the most likely epistemic state of the speaker is given a certain expression. To execute the latter task in a fully rational manner, participants have to perform higher-order reasoning about alternative expressions the speaker could have used. Under the assumption that participants do not always perform such higher-order reasoning but also often resort to so-called unidirectional optimization, the task effect finds a natural explanation. This also allows us to relate our finding to asymmetries between comprehension and production that have been found in language acquisition.
Philosophers in research ethics committees—what do they think they’re doing? An empirical-ethical analysis
Authors: Gauckler Charlotte 
Published: August 2021

AbstractResearch ethics committees in Germany usually don’t have philosophers as members and if so, only contingently, not provided for by statute. This is interesting from a philosophical perspective, assuming that ethics is a discipline of philosophy. It prompts the question what role philosophers play in those committees they can be found in. Eight qualitative semi-structured interviews were conducted to explore the self-perception of philosophers regarding their contribution to research ethics committees. The results show that the participants generally don’t view themselves as ethics experts. They are rather unanimous on the competencies they think they contribute to the committee but not as to whether those are philosophical competencies or applied ethical ones. In some cases they don’t see a big difference between their role and the role of the jurist member. In the discussion section of this paper I bring up three topics, prompted by the interviews, that need to be addressed: (1) I argue that the interviewees’ unwillingness to call themselves ethics experts might have to do with a too narrow understanding ofethics expertise. (2) I argue that the disagreement among the interviewees concerning therelationship between moral philosophy and applied ethicsmight be explained on a theoretical or on a practical level. (3) I argue that there is some lack of clarity concerning therelationship between ethics and lawin research ethics committees and that further work needs to be done here. All three topics, I conclude, need further investigation.
Jeremy is a... Expressive-relativism and expressives in predicative positions
Authors: Berškytė Justina 
Published: August 2021

AbstractExpressives are words that convey speakers’ attitudes towards a particular object or situation. Consider two examples:

Attributive: That f**khead Jeremy forgot the turkey.

Predicative: Jeremy is a f**khead.

In both examples the word f**khead communicates some expressive content - the negative attitude of the speaker. However, only in Predicative does it appear to contribute to the truth-conditional content. The task is to explain the semantics of the word f**khead when it seemingly behaves wildly differently in different syntactic positions. In this paper I consider several good candidates for dealing with f**khead occurring in Predicative position: Expressivist and Descriptive approaches that treat f**khead in Predicative as purely descriptive; and Expressive-Contextualism that treats Predicative as communicating to both expressive and descriptive dimensions. I show that none of the options fully capture the meaning of f**khead. Treating Predicative as purely descriptive leaves out the highly important expressive element, whilst Contextualist semantics does not seem as a suitable descriptive theory for expressives. I finally present a novel hybrid account that combines Expressivist semantics with Relativism. I call this view Expressive-Relativism. I show that by adopting Expressive-Relativism we can not only explain the relationship of f**khead in Attributive and Predicative, but also give a suitable descriptive theory that captures the truth-conditions of Predicative.
The impact of chemotherapy-induced inner ear damage on quality of life in cancer survivors: a qualitative study
Authors: Pearson Stephanie E. , Caimino Charlotte , Shabbir Maryam , Baguley David M. 
Published: August 2021

Abstract
Purpose
This study aimed to explore the burden of inner ear damage (ototoxicity) on adults living with and beyond cancer treated with chemotherapy and the impact on their quality of life (QoL). Furthermore, this study aimed to explore patient awareness surrounding chemotherapy-induced inner ear damage, known as ototoxicity, and assess what support they had been offered.

Methods
Participants were adults who had undergone chemotherapy, recruited from cancer clinics, charities and social media. Using semi-structured interviews and fieldnotes, an inductive thematic analysis was used to develop key themes surrounding this topic.

Results
Twenty participants from the UK were interviewed. Two key themes were developed from the thematic analysis, cancer-related QoL and ototoxicity-related QoL, with each one including 5 subthemes. Subthemes consisted of impact of ototoxicity, hearing, tinnitus, clinical experience, audiological assessments, and impact of treatment, cancer and chemotherapy, other toxicities, information and patient reflections.

Conclusions
Ototoxicity can have a negative impact on QoL, specifically on social life and the fear of hearing loss and/or tinnitus worsening. There are opportunities for increased awareness by patients and clinicians, including improved information sources, and hearing monitoring not only for those undergoing platinum-based chemotherapy but many others surviving after treatment for cancer.

Implications for Cancer Survivors
Better monitoring of hearing and information about ototoxicity during chemotherapy could potentially reduce the fear of the symptoms of ototoxicity worsening. Furthermore, hearing monitoring would facilitate the detection of hearing loss at early stages of survivorship, which would facilitate earlier access to clinical interventions and longer term counselling.
Investigating spatio-temporal mobility patterns and changes in metro usage under the impact of COVID-19 using Taipei Metro smart card data
Authors: Mützel Christian Martin , Scheiner Joachim 
Published: August 2021

AbstractModern public transit systems are often run with automated fare collection (AFC) systems in combination with smart cards. These systems passively collect massive amounts of detailed spatio-temporal trip data, thus opening up new possibilities for public transit planning and management as well as providing new insights for urban planners. We use smart card trip data from Taipei, Taiwan, to perform an in-depth analysis of spatio-temporal station-to-station metro trip patterns for a whole week divided into several time slices. Based on simple linear regression and line graphs, days of the week and times of the day with similar temporal passenger flow patterns are identified. We visualize magnitudes of passenger flow based on actual geography. By comparing flows for January to March 2019 and for January to March 2020, we look at changes in metro trips under the impact of the coronavirus pandemic (COVID-19) that caused a state of emergency around the globe in 2020. Our results show that metro usage under the impact of COVID-19 has not declined uniformly, but instead is both spatially and temporally highly heterogeneous.
Construction of 1D Heterostructure NiCo@C/ZnO Nanorod with Enhanced Microwave Absorption
Authors: Wang Jianwei , Jia Zirui , Liu Xuehua , Dou Jinlei , Xu Binghui , Wang Bingbing , Wu Guanglei 
Published: August 2021

AbstractLayered double hydroxides (LDHs) have a special structure and atom composition, which are expected to be an excellent electromagnetic wave (EMW) absorber. However, it is still a problem that obtaining excellent EMW-absorbing materials from LDHs. Herein, we designed heterostructure NiCo-LDHs@ZnO nanorod and then subsequent heat treating to derive NiCo@C/ZnO composites. Finally, with the synergy of excellent dielectric loss and magnetic loss, an outstanding absorption performance could be achieved with the reflection loss of − 60.97 dB at the matching thickness of 2.3 mm, and the widest absorption bandwidth of 6.08 GHz was realized at 2.0 mm. Moreover, this research work provides a reference for the development and utilization of LDHs materials in the field of microwave absorption materials and can also provide ideas for the design of layered structural absorbers.
Entropy-regularized 2-Wasserstein distance between Gaussian measures
Authors: Mallasto Anton , Gerolin Augusto , Minh Hà Quang 
Published: August 2021

AbstractGaussian distributions are plentiful in applications dealing in uncertainty quantification and diffusivity. They furthermore stand as important special cases for frameworks providing geometries for probability measures, as the resulting geometry on Gaussians is often expressible in closed-form under the frameworks. In this work, we study the Gaussian geometry under the entropy-regularized 2-Wasserstein distance, by providing closed-form solutions for the distance and interpolations between elements. Furthermore, we provide a fixed-point characterization of a population barycenter when restricted to the manifold of Gaussians, which allows computations through the fixed-point iteration algorithm. As a consequence, the results yield closed-form expressions for the 2-Sinkhorn divergence. As the geometries change by varying the regularization magnitude, we study the limiting cases of vanishing and infinite magnitudes, reconfirming well-known results on the limits of the Sinkhorn divergence. Finally, we illustrate the resulting geometries with a numerical study.