bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomechanical Effects of Lateral Inclination C1 and C2 Pedicle Screws on Atlantoaxial Fixation
Authors: Zhang Lei , Wang Huan 
Published: September 2021

ObjectiveTo assess the biomechanical effect of lateral inclination C1 and C2 pedicle screws on the atlantoaxial fixation through vitro human cadaveric study.MethodsFrom January 2016 to December 2017, fresh‐frozen cadaveric cervical spines with intact ligaments from eight donated cadavers at an average age of 71.5 ± 10.6 years, comprising of six males and two females, were collected. There were no fracture and congenital malformation in all specimens according to the imaging examination. The range of motion (ROM) of the specimens were tested in their intact condition and destabilized condition. Next, the specimens were randomly divided into two groups to ensure no differences in sex and age: Group 1 was medial inclination C1 pedicle screw and C2 pedicle screws (C1MPS‐C2PS) and Group 2 was lateral inclination C1 pedicle screw and C2 pedicle screws (C1LPS‐C2PS). The ROM of the fixation scenarios were recorded. Thereafter, all the specimens with fixation constructs were tested for 1,000 cycles of axial rotation and tensile loading to failure was carried out collinearly to the longitudinal axis of all the screws, the data were documented as screw pullout strength (SPS) in newtons. All the recorded data subjected to quantitative analysis.ResultsThe ROM of specimens was increased significantly in destabilized condition and significantly reduced in fixation condition compared with intact condition. In C1LPS‐C2PS groups, the C1‐C2 cervical segment showed 3.96° ±1.21° and 3.75° ± 1.33° in flexion and extension direction, 2.85° ± 0.91° and 2.96° ± 0.71° in right and left lateral bending, 2.20° ± 0.43° and 2.15° ± 0.40° in right and left axial rotation. In C1MPS‐C2PS groups, it showed 4.24° ±1.31° and 3.98° ± 1.21° in flexion and extension direction, 2.76° ± 1.10° and 3.23° ± 0.62° in right and left lateral bending, 2.20° ± 0.46° and 2.21° ± 0.42° in right and left axial rotation. There was no statistically significant difference on ROM and screw pullout strengths (764.29 ± 129.00 N vs 714.55 ± 164.63 N) between the two groups. However, there was one specimen in the C1MPS‐C2PS group showing rupture the inferior wall of the left screw trajectory owing to the relatively thin posterior arch of the atlas, the screw pullout strength was significantly reduced (left pullout strength value: 430.5 N, right pullout strength value: 748.4 N). Therefore, in the case of the thin posterior arch of the atlas, the C1LPS‐C2PS group had strong long‐term biomechanics.ConclusionThe lateral inclination C1 pedicle screw can achieve the same biomechanical strength as the traditional atlas pedicle screw. However, for the case where the posterior arch of the atlas is relatively thin, a lateral inclination C1 pedicle screw is more suitable.
Why they keep missing: An empirical investigation of sovereign bond ratings and their timing*
Authors: El‐Shagi Makram , von Schweinitz Gregor 
Published: September 2021

AbstractTwo contradictory strands of the rating literature criticize that rating agencies merely follow the market on the one hand, and emphasizing that rating changes affect capital movements on the other hand. Both focus on explaining rating levels rather than the timing of rating announcements. Contrarily, we explicitly differentiate between a decision to assess a country and the actual rating decision. We show that this differentiation significantly improves the estimation of the rating function. The three major rating agencies treat economic fundamentals similarly, while differing in their response to other factors such as strategic considerations. This reconciles the conflicting literature.
Metallogenic fingerprint of a metasomatized lithospheric mantle feeding gold endowment in the western Mediterranean basin
Authors: Schettino Erwin , Marchesi Claudio , González-Jiménez José María , Saunders Edward , Hidas Károly , Gervilla Fernando , Garrido Carlos J. 
Published: September 2021

AbstractSpinel peridotite xenoliths (one plagioclase-bearing) hosted in alkaline basalts from Tallante (southeast Spain) record the mineralogical and geochemical fingerprint of the subcontinental lithospheric mantle (SCLM) evolution beneath the southern Iberian margin. Mantle metasomatism in fertile lherzolites caused the crystallization of clinopyroxene + orthopyroxene + spinel clusters through the percolation of Miocene subalkaline melts during the westward migration of the subduction front in the western Mediterranean. In the Pliocene, heat and volatiles provided by alkaline host-magmas triggered very low melting degrees of metasomatic pyroxene-spinel assemblages, producing melt quenched to silicate glass and reactive spongy coronae around clinopyroxene and spinel. Refertilization of the Tallante peridotites induced the precipitation of base-metal sulfides (BMS) included in metasomatic clino- and orthopyroxene. These sulfides consist of pentlandite ± chalcopyrite ± bornite aggregates with homogeneous composition in terms of major elements (Ni, Fe, Cu) and semi-metals (Se, As, Te, Sb, Bi), but with wide variability of platinum-group elements (PGE) fractionation (0.14 &lt; PdN/IrN &lt; 30.74). Heterogeneous PGE signatures, as well as the presence of euhedral Pt-Pd-Sn-rich platinum-group minerals (PGM) and/or Au-particles within BMS, cannot be explained by conventional models of chalcophile partitioning from sulfide melt. Alternatively, we suggest that they reflect the incorporation of distinct populations of BMS, PGM, and metal nanoparticles (especially of Pt, Pd, and Au) during mantle melting and/or melt percolation. Therefore, we conclude that Miocene subalkaline melts released by asthenosphere upwelling upon slab tearing of the Iberian continental margin effectively stored metals in metasomatized domains of this sector of the SCLM. Remarkably high Au concentrations in Tallante BMS (median 1.78 ppm) support that these metasomatized domains provided a fertile source of metals, especially gold, for the ore-productive Miocene magmatism of the westernmost Mediterranean.
Unraveling the histories of Proterozoic shales through in situ Rb-Sr dating and trace element laser ablation analysis
Authors: Subarkah Darwinaji , Blades Morgan L. , Collins Alan S. , Farkaš Juraj , Gilbert Sarah , Löhr Stefan C. , Redaa Ahmad , Cassidy Eilidh , Zack Thomas 
Published: September 2021

Abstract
Authigenic components in marine sediments are important archives for past environment reconstructions. However, defining reliable age constraints and assessing the effects of post-depositional overprints in Precambrian sequences are challenging. We demonstrate a new laser-based analytical approach that has the potential to rapidly and accurately evaluate the depositional and alteration histories of Proterozoic shales. Our study employs a novel application of in situ Rb-Sr dating coupled with simultaneous trace-element analysis using reaction-cell laser ablation–inductively coupled plasma–tandem mass spectrometry (LA-ICP-MS/MS). We present results from shales sourced from two wells in the Proterozoic McArthur Basin, northern Australia. These rocks have been widely used by previous studies as a key section for ancient biogeochemical and paleo-redox reconstructions. Shales from well UR5 yielded initial 87Sr/86Sr ratios, Rb-Sr ages, and rare earth element plus yttrium (REEY) patterns similar to those of a dolerite sampled from the same core. We propose that the UR5 samples chronicle hydrothermal alteration instigated by the dolerite intrusion. In contrast, a correlative shale from well UR6 yielded an age consistent with the expected depositional age (1577 ±56 Ma) with REEY and initial 87Sr/86Sr ratios similar to ca. 1.5 Ga seawater. We suggest that this sample records the minimum depositional age and early marine diagenetic history for this unit. This new technique can date Proterozoic shales quickly, cheaply, and with minimum sample preparation. Importantly, ages are triaged to differentiate between those recording primary marine versus secondary processes. This novel approach provides a potentially powerful tool for dating and fingerprinting the vast array of ancient marine shales for further studies of Earth systems through deep time.
Linking lava morphologies to effusion rates for the 2014–2015 Holuhraun lava flow field, Iceland
Authors: Voigt Joana R.C. , Hamilton Christopher W. , Steinbrügge Gregor , Höskuldsson Ármann , Jónsdottir Ingibjörg , Thordarson Thorvaldur 
Published: September 2021

AbstractDetermining the parameters that control fissure-fed lava morphologies is critical for reconstructing the complex emplacement histories of eruptions on Earth and other planetary bodies. We used a geomorphological map of the 2014–2015 Holuhraun lava flow field, in combination with new constraints on lava emplacement chronology and two independently derived time-averaged discharge rate (TADR) data sets, to analyze correlations between lava morphology and effusion rate. Results show that lava morphologies are dominantly controlled by effusion rate at the vent during the early phases of the eruption and by lava transport processes as the system evolves. Initially, TADR and its variance, which reflect pulsation in the lava supply rate from the vent, directly affect lava emplacement styles. However, as the eruption progresses, the lava transport system exerts a stronger control with channels and ponds that can either dampen variation in local effusion rate or create surges during sudden drainage events. The Holuhraun eruption predominantly produced rubbly lava in its earlier eruption phases and transitioned into the production of spiny lava toward the end of the eruption. However, a drop of TADR during the first phase of the eruption correlates with a decrease in rubbly lava formation and an increase in spiny lava production. This suggests that a change in effusion rate caused the observed transition in lava type. Our findings show that rubbly lava is formed under relatively high local effusion rates with pulsating supply conditions, whereas spiny lava is formed under lower local effusion rates and steadier supply.
Some Indicators of Nonspecific Immunity of Various Breeding Groups of Carp in Different Periods of the Annual Cycle
Authors: Mikryakov D. V. , Pronina G. I. , Suvorova T. A. , Sokolova A. S. , Mikryakov V. R. , Petrushin A. B. 
Published: September 2021

Abstract
A comparative study of some parameters of nonspecific immunity in the Angelinskii rubella-resistant variant of the scaly and mirror groups of carp in the prespawning and late feeding periods was carried out. The level of the antimicrobial properties of the C-reactive protein, nonspecific immune complexes in the blood serum, and phagocytic activity of neutrophils were studied. The study showed interbreed and inter-seasonal differences in some indicators. It is concluded that the higher level of bacteriostatic activity of blood serum in the rubella-resistant variant, compared with other groups of carp, provides a low percentage of immunodeficient individuals and resistance to pathogens of infectious diseases.
Safety and efficacy of low-dose diazoxide in small-for-gestational-age infants with hyperinsulinaemic hypoglycaemia
Authors: Chandran Suresh , R Pravin R , Mei Chien Chua , Saffari Seyed Ehsan , Rajadurai Victor Samuel , Yap Fabian 
Published: September 2021

ObjectivesDiazoxide (DZX) is the drug of choice for treating hyperinsulinaemic hypoglycaemia (HH), and it has potentially serious adverse effects. We studied the safety and efficacy of low-dose DZX in small-for-gestational-age (SGA) infants with HH.DesignAn observational cohort study from 1 September 2014 to 31 September 2020.SettingA tertiary Women’s and Children’s Hospital in Singapore.PatientsAll SGA infants with HH.InterventionDiazoxide, at 3–5 mg/kg/day.Main outcome measuresShort-term outcomes; adverse drug events and fasting studies to determine ‘safe to go home’ and ‘resolution’ of HH.ResultsAmong 71 836 live births, 11 493 (16%) were SGA. Fifty-six (0.5%) SGA infants with HH were identified, of which 27 (47%) with a mean gestational age of 36.4±2 weeks and birth weight of 1942±356 g required DZX treatment. Diazoxide was initiated at 3 mg/kg/day at a median age of 10 days. The mean effective dose was 4.6±2.2 mg/kg/day, with 24/27 (89%) receiving 3–5 mg/kg/day. Generalised hypertrichosis occurred in 2 (7.4%) and fluid retention in 1 (3.7%) infant. A fasting study was performed before home while on DZX in 26/27 (96%) cases. Diazoxide was discontinued at a median age of 63 days (9–198 days), and resolution of HH was confirmed in 26/27 (96%) infants on passing a fasting study.ConclusionOur study demonstrates that low-dose DZX effectively treats SGA infants with HH as measured by fasting studies. Although the safety profile was excellent, minimal adverse events were still observed with DZX, even at low doses.
Diagnostic accuracy of point-of-care ultrasound (PoCUS) for shoulder dislocations and reductions in the emergency department: a diagnostic randomised control trial (RCT)
Authors: Attard Biancardi Mark Anthony , Jarman Robert David , Cardona Tania 
Published: September 2021

BackgroundFollowing blunt trauma, diagnosis of shoulder dislocation based on physical examination alone is difficult due to possible concurrent proximal humeral fractures. X-rays are therefore used to confirm diagnosis. Results from recent observational studies comparing diagnostic accuracy of point-of-care ultrasound (PoCUS) with X-rays for shoulder dislocation have been encouraging. The aim of this study was to determine whether PoCUS improves diagnostic accuracy when used with physical examination for the diagnosis of shoulder dislocation, proximal humeral fracture and ascertaining successful reduction in the ED.MethodsA prospective, single-centre, open, parallel randomised control study over a 6-month period was used to answer the research question and test the null hypothesis. Consecutive eligible adult patients attending the ED of Mater Dei Hospital in Malta were randomised to either the control (C) (physical examination only) or experimental group (E) (physical examination and a two-point PoCUS scan). The study objectives were to measure diagnostic accuracy for both examinations for detecting shoulder dislocation, any associated proximal humeral fractures and confirming reduction. X-rays were used as reference standard for both groups.Results1206 patients were enrolled in this study (C n=600, E n=606). 290 dislocations (C n=132 and E n=158), 332 proximal humeral fractures (C n=154 and E n=178) and 278 reductions (C n=130 and E n=148) were analysed. A statistically significant difference (p<0.001) was found between the two groups for diagnostic accuracy in shoulder dislocation (C=65%, likelihood ratio (LR)+=2.03 and LR−=0.35 and E=100%, LR+=∞ and LR−=0), proximal humeral fractures (C=45.7%, LR+=1.23 and LR−=0.52 and E=98.3%, LR+=103.9 and LR−=0.03) and reduction (C=68.7%, E=100%). The null hypothesis for this study was thus rejected.ConclusionsThe addition of PoCUS to a physical examination significantly improves diagnostic accuracy for dislocations, proximal humeral fractures and reduction confirmation.Trial registration numberInternational Standard Randomised Controlled Trials Number Registry (ISRCTN17048126).
Ball magnet ingestion in children: a stronger and more dangerous attraction?
Authors: Price James , Malakounides Georgina , Stibbards Sarah , Agrawal Shruti 
Published: September 2021

IntroductionThe ingestion of small, strong, rare-earth magnets, also termed ‘ball magnets’, can rapidly result in life-threatening bowel injuries. The objective of this study was to report the incidence and management of ‘ball magnet’ ingestion in children across the UK and to discuss the potential implications for policy-makers and public awareness campaigns.MethodsIn this multi-centre survey of UK major trauma centres (MTCs), paediatric patients admitted to hospital following ‘ball magnet’ ingestion from 1 January 2020 to 31 December 2020 were included.ResultsResponses were received from 11 MTCs (52%) reporting a total of 53 children admitted with ‘ball magnet’ ingestion over the 1-year study period. Most patients (n=51) presented following unintentional ingestion. 36 (68%) patients presented asymptomatically following witnessed or reported ingestion. In symptomatic patients, abdominal pain and vomiting were the the most common symptoms. The median number of ‘ball magnets’ ingested was 5.0 (IQR 3.0–7.8), range 1 to 63. 27 (51%) patients underwent operative intervention; laparotomy being the the most common (n=24, 89%). There were no deaths reported during the study period.ConclusionThis multi-centre survey from the UK demonstrates the serious impact of ‘ball magnet’ ingestion in children. Clinicians, regulators and caregivers must work symbiotically in order to prevent, recognise and reduce life-threatening bowel injuries.
Unionisation and injury risk in construction: a replication study
Authors: Robson Lynda S , Landsman Victoria , Latour-Villamil Desiree , Lee Hyunmi , Mustard Cameron 
Published: September 2021

ObjectiveTo replicate, in a more recent time period, a previous cross-sectional study to estimate the association between unionisation and the risk of workers’ compensation injury claims.MethodsThe sampling frame was workers’ compensation company account records in the industrial, commercial and institutional construction sector in the province of Ontario, Canada, 2012–2018. Company unionisation status was determined through linkage with records of unionised contractors. Outcomes were cumulative counts of workers’ compensation injury claims, aggregated to company business. Risk ratios were estimated with multivariable negative binomial regression models. Models were also fit separately to lost-time claims stratified by company size.ResultsBusiness unionisation was associated with a lower lost-time claim incidence (crude risk ratio, CRR=0.69, 95% CI 0.65 to 0.74); adjusted risk ratio, ARR=0.75, 95% CI 0.71 to 0.80). In subgroup analyses, the magnitude of the ARR declined as company size decreased and was not statistically significant for the smallest-sized companies of ≤4 full-time equivalent employees. Unionisation was associated (positively) with the incidence of no-lost-time claims in a crude model, but not in an adjusted one (CRR=1.80, 95% CI 1.71 to 1.89; ARR=1.04, 95% CI 0.98 to 1.09).ConclusionsCompany unionisation was associated with a lower risk of lost-time workers’ compensation injury claims, corroborating a similar study from an earlier time period. The protective effect of unionisation declined as company size decreased. In contrast to the previous study, a positive relationship between company unionisation and no-lost-time claim incidence was not found, due in part to a methodological refinement.
Archaeological applications of natural gold analyses
Authors: Standish C. D. , Chapman R. J. , Moles N. R. , Walshaw R. D. , Sheridan J. A. 
Published: September 2021

Abstract
Compositional studies of natural gold usually have a geological focus, but are also important in archaeological provenancing. Both methodologies rely on compositional comparison of two sets of samples, one of which is geographically constrained. Here we describe how experiences in gold characterization resulting from geological studies are relevant to archaeology. Microchemical characterization of polished sections of natural gold identifies alloy compositions, alloy heterogeneity and mineral inclusions. Gold from all deposit types shows Cu and Sn values much lower than those recorded during numerous studies of artefacts. Inclusions in artefact gold include various Cu- and Sn-bearing compounds which indicate specific high temperature reactions that could ultimately illuminate the conditions of (s)melting. The use of LA-ICP-MS to generate a wide range of elemental discriminants for provenance studies may be compromised by alloy adulteration and/or unrepresentative analysis of natural/artefact alloys, which are commonly highly heterogeneous at the micron scale. Geological studies normally characterize only the earliest-formed (hypogene) alloy, whereas archaeology-focused studies should entail analyses of bulk alloy compositions and impurities that may be incorporated during (s)melting. Isotopic-based provenancing alleviates many of these problems but, to date, generates regional rather than locality-specific targets. A dual isotopic–compositional approach is recommended.
Between Principles & Power: Water Law Principles & the Governance of Water in Post-Apartheid South Africa
Authors: Klug Heinz 
Published: September 2021

Abstract
Debates over the management and allocation of water in the postcolonial era, and in post-apartheid South Africa in particular, reveal that struggles over water resources in Southern Africa occur within three broad frames: the institutional, the hydrological, and the ideological. Each of these realms reflects tensions in the relationship between power and principle that continue to mark the governance of water. Each perspective offers a way to understand the use and the limits of law in the management of a country's water resources. The existence of explicit principles, whether as policy guidelines, constitutional rights, or in the language of regional and international agreements, provides two important resources for those who struggle for access to water. First, a vision of a more just allocation of this fundamental resource and, second, an articulation of common benchmarks to which states and governments might be held to account.
Gender Bias in Machine Translation
Authors: Savoldi Beatrice , Gaido Marco , Bentivogli Luisa , Negri Matteo , Turchi Marco 
Published: September 2021

AbstractMachine translation (MT) technology has facilitated our daily tasks by providing accessible shortcuts for gathering, processing, and communicating information. However, it can suffer from biases that harm users and society at large. As a relatively new field of inquiry, studies of gender bias in MT still lack cohesion. This advocates for a unified framework to ease future research. To this end, we: i) critically review current conceptualizations of bias in light of theoretical insights from related disciplines, ii) summarize previous analyses aimed at assessing gender bias in MT, iii) discuss the mitigating strategies proposed so far, and iv) point toward potential directions for future work.