bluuebunny/crossref_metadata_2025_split huggingface dataset:
SISTEM PENDUKUNG KEPUTUSAN UNTUK PENERIMAAN KARYAWAN BARU BERBASIS CLIENT SERVER
Authors: Hernando Luki 
Published: February 2021

Abstract: PT. Pia Garda Utama is one of the outsourcing service providers in the West Sumatra region. The company still uses Microsoft Excel to store data from fans, ranging from recruitment, initial selection to the appointment of prospective employees. During this time the process of hiring employees at PT. Pia Garda is still not effective or recommended, which still requires a long time in determining the final results in accordance with the criteria set by the company. The processes carried out by PT. Pia Garda Utama is very unfavorable for applicants or prospective employees, this may not be the pure results of the applicant's ability, more than the results of the thoughts and conclusions of the examiners. To overcome these problems, a Decision Support System was created which will assist in processing the exam data of the applicants so as to produce an effective and efficient decision that can assist the company in determining the criteria for prospective buyers needed by the company. Keywords: decision support system; client server; employee acceptance Abstrak: PT. Pia Garda Utama merupakan salah satu perusahaan penyedia jasa Outsourcing di wilayah Sumatera Barat. Perusahaan masih menggunakan microsoft excel untuk menyimpan data-data dari para pelamar, mulai dari Perekrutan, penyeleksian awal sampai pada tahap penentuan calon karyawan. Selama ini Proses penerimaan karyawan di PT. Pia Garda Utama masih belum efektif atau subjektif yang masih membutuhkan waktu yang cukup lama dalam menentukan hasil akhir penerimaan karyawan yang sesuai dengan kriteria yang ditetapkan perusahaan. Proses –proses yang dilaksanakan oleh PT. Pia Garda Utama sangat tidak menguntungkan bagi pelamar atau calon karyawan, hal ini dikarenakan hasil yang didapat bisa dikatakan bukan murni dari kemampuan pelamar tersebut, melainkan dari hasil pemikiran dan kesimpulan para penguji. Untuk mengatasi permasalahan tersebut maka dibuat suatu Sistem Penunjang Keputusan (SPK) yang akan membantu dalam mengolah data ujian dari pelamar sehingga menghasilkan sebuah keputusan yang efektif dan efisien yang dapat membantu perusahaan dalam menentukan kriteria calon karyawan yang dibutuhkan oleh perusahaan. Kata kunci: client server; penerimaan karyawan; sistem pendukung keputusan
ANALISIS PERBANDINGAN MENGGUNAKAN METODE MOORA DAN WASPAS PEMILIHAN BIBIT SAPI POTONG TERBAIK
Authors: Afrisawati Afrisawati , Sahren Sahren 
Published: February 2021

Abstract: The need for fulfilling the quantity and quality of beef in Indonesia is still very less than the supply of beef in Indonesia, for 2020 alone the demand for beef in Indonesia is around 700,000 tons while the domestic supply is only 400,000 tons, from that Indonesia is still 300,000 tons less. Therefore, to meet the beef needs, an additional supply of beef is needed by importing beef from abroad in the form of processed meat and prospective beef breeders. The problem experienced by independent local breeders is the selection of the best cattle breeds The process of selecting cattle breeds conducted so far by farmers is still manual and traditional. They did this because of the lack of qualified knowledge to choose the best beef breed based on certain criteria and which alternative cow options are suitable for beef cattle. So that the process of enlarging cattle breeds becomes shorter in time with maximum results. The technology used is using the MOORA and WASPAS methods as a comparison in determining the best beef cattle breeds. The method is expected to produce a comparison so that the results obtained from a more accurate method in selecting the best beef breeders in order to advance the local independent livestock business in particular and become self-sufficient beef in general. Keywords: Beef Cattle; decision support system; MOORA; WASPAS Abstrak: Kebutuhan akan pemenuhan kuantitas dan kualitas daging sapi di indonesi sangat masih kurang dari persedian sapi yang ada di Indonesia, untuk tahun 2020 ini sendiri kebutuhan akan daging sapi di Indonesia sekitar 700.000 ton sementara persedian dalam negeri hanya mencapai 400.000 ton, dari itu Indonesia masih kurang 300.000 ton lagi. Oleh karena itu, untuk mencukupi kebutuhan daging sapi tersebut diperlukan tambahan suplai daging sapi dengan melakukan impor daging sapi dari luar negeri baik berupa daging olahan maupun bakalan calon bibit sapi. Masalah yang dialami oleh para peternak lokal mandiri yaitu pemilihan bibit sapi terbaik Proses pemilihan bibit sapi yang dilakukan selama ini oleh peternak masih dengan cara manual dan tradisional. Hal tersebut mereka lakukan Karena kurangnya pengetahuan yang mumpuni untuk memilih bibit sapi terbaik berdasarkan kriteria-kriteria tertentu dan beberapa pilihan alternatif sapi mana yang cocok untuk dijadikan sapi potong. Sehingga dengan demikian proses pembesaran bibit sapi menjadi lebih singkat waktunya dengan hasil yang maksimal. Teknologi yang digunakan yaitu menggunakan metode MOORA dan WASPAS sebagai pembanding dalam menetukan bibit sapi potong terbaik. Dari metode tersebut diharapkan menghasilkan perbandingan sehingga didapat hasil dari metode yang lebih akurat dalam pemilihan bibit sapi terbaik demi memajukan usaha peternakan mandiri lokal secara khusus dan menjadi swasembada daging sapi secara umum. Kata Kunci: bibit sapi; sistem penunjang keputusan; MOORA; WASPAS
Implementasi Pembelajaran Alquran Hadist Berbasis Problem Solving untuk Membentuk Critikal Thinking Siswa Kelas IX di MTs. Nasy’atul Mujahidin Ringinrejo Tiru Lor Gurah Kediri
Authors: Kusniyah Alfin , Tjahja Dini Sri Susanti 
Published: February 2021

Problem solving merupakan salah satu metode pembelajaran yang penting biasanya digunakan dalam pembelajaran yang membutuhkan jawaban dan pemecahan permasalahan. Metode ini sangat baik digunakan untuk pembinaan sikap ilmiah siswa agar terbiasa memecahkan masalah secara prosedur kerja ilmiah. Critical Thinking merupakan kegiatan berfikir kritis yang dilakukan dengan mengoperasikan potensi intelektual untuk menganalisis, membuat pertimbangan dan mengambil keputusan secara tepat dan melaksanakan secara benar. Strategi Pemecahan masalah Solso dalam Made Wena mengemuka enam tahap dalam pemecahan masalah , yaitu: 1) Identifikasi permasalaahn (identification the problem), 2) Representasi permasalaahn (representation of the problem), 3) Perencanaan pemecahan (planning the solution), 4) Menerapkan /mengimplementasikan perencanaan (executethe plan), 5) Menilai perencanaan (evaluate the plan ), 6) Menilai hasil pemecahan (evaluate the solution). Wankat dan Oreovocz dalam Made Wena mengemukakan tahap –tahap strategi operasional dalam pemecahan masalah sebagai berikut: a) Saya mampu/bisa (I can ). b) Mendefinisikan (define). c) Mengeksplorasi (eksplore). d) Merencanaakan plan (plan). e) Mengoreksi kembali (check). f) Generalisasi (generalize). Hasil proses Implementasi Pembelajaran Berbasis Problem Solving Untuk Meningkatkan Critical Thinking (Hasil belajar) siswa di MTs. Nasy’atul Mujahidin di Ringin Rejo Tiru Lor Gurah Kediri terbagi menjadi dua faktor yaitu :faktor interenn dan exsteren, faktor interen Yaitu: Hendaknya guru lebih menjelaskan lebih dalam perencanaan permasalahan agar para siswa mampu mendiskripsikan secara cepat tanggap kreatif, kritis, idealis, bertanya dalam secara individu dan kelompok. Kurangnya motivasi siswa dari siswa itu sendiri, padatnya aktivitas siswa yang mukim sehingga ada siswa yang mengantuk, kurang antusias karena faktor individu,latar belakang pendidikan yang non agama islam, kurangnya memahami pertanyaan. Sedangkan faktor exterens yaitu: padatnya aktivitas, kurangnya sarana dan prasarana,kelelahan karena padatnya aktivitas bagi siswa mukim, lingkungan keluarga yang non agama, latar belakang pendidikan non Islam.
Some Die Young
Authors: Silow Kallenberg Kim 
Published: February 2021

This is an ethnographic and an autoethnographic study based on qualitative interviews as well as memories and experiences of the author. It focuses on two men that were childhood friends of the author and who both died prematurely. Marcus died in November 2013 while he was under psychiatric care due to auditory hallucinations and anxiety. Noel died little over a year later, in January 2015, from an overdose of heroin. The aim of the article is to analyse the narratives of women and is concerned with understanding the loss of a son, a brother, or a former boyfriend or friend due to substance abuse or mental health problems. The empirical cases analysed in this text are women’s understandings of the deaths of Marcus and Noel – two young men who were close to them in different ways. Their narratives about the men, their memories, and their rationalisations for what happened to them are analysed. The analysis shows that when the women talk about, and try to explain, the male lives that led up to the death, a limited number of narratives are available. Narratives about absent and/or abusive fathers, narratives about mothers who fail in providing the expected care, and narratives about shortcomings in psychiatric services and community support are dominant in the analysed material. In relation to these available narratives, the story follows the making of a protest masculinity in which elements such as rock star dreams, violence, drug use, and talk of legalising drugs have a place. Together they form an overarching narrative about protest masculinity; i.e. ways to act in reaction to a perceived alienation or subordination by acting out in ways associated with masculinity.
Circ_0065149 Alleviates Oxidized Low-Density Lipoprotein-Induced Apoptosis and Inflammation in Atherosclerosis by Targeting miR-330-5p
Authors: Li Dan , Jin Wen , Sun Li , Wu Jiawei , Hu Hao , Ma Likun 
Published: February 2021

BackgroundAtherosclerosis is a risk factor for cardiovascular diseases. However, the roles of Circular RNAs (circRNAs) in atherosclerosis is unknown. Our study aimed to explore the effects of circ_0065149 in the pathogenesis of atherosclerosis.MethodsThe expression of circ_0065149 ox-LDL-induced in human umbilical vein endothelial cells (HUVECs) was assessed by RT-PCR. Cell viability, lactate dehydrogenase leakage, apoptosis, invasion, and migration were assessed in HUVECs. Dual luciferase reporter system was carried out to determine the interaction between miR-330-5p and circ_0065149.ResultsOur results showed that circ_0065149 was significantly lower in the ox-LDL-induced HUVECs. Overexpression of circ_0065149 promoted the cell viability and inhibited the apoptosis of ox-LDL-induced HUVECs. Overexpression of circ_0065149 also promoted the migration and invasion of ox-LDL-induced HUVECs. The expression of miR-330-5p was inhibited by overexpression of circ_0065149. Furthermore, circ_0065149 overexpression significantly inhibited the expressions of nuclear NF-κBp65 and suppressed the production of TNF-α, IL-6, and IL-1β in ox-LDL-induced HUVECs, which was rescued by the miR-330-5p mimic.ConclusionThese findings suggest that circ_0065149 plays an important role in the proliferation, apoptosis, and inflammatory response of HUVECs via targeting miR-330-5p.
Gut Microbiota Profile in Pediatric Patients With Inflammatory Bowel Disease: A Systematic Review
Authors: Zhuang Xiaojun , Liu Caiguang , Zhan Shukai , Tian Zhenyi , Li Na , Mao Ren , Zeng Zhirong , Chen Minhu 
Published: February 2021

Background and Aim: Accumulating evidence have implicated gut microbiota alterations in pediatric and adult patients with inflammatory bowel disease (IBD); however, the results of different studies are often inconsistent and even contradictory. It is believed that early changes in new-onset and treatment-naïve pediatric patients are more informative. We performed a systematic review to investigate the gut microbiota profiles in pediatric IBD and identify specific microbiota biomarkers associated with this disorder.Methods: Electronic databases were searched from inception to 31 July 2020 for studies that observed gut microbiota alterations in pediatric patients with IBD. Study quality was assessed using the Newcastle–Ottawa scale.Results: A total of 41 original studies investigating gut microbiota profiles in pediatric patients with IBD were included in this review. Several studies have reported a decrease in α-diversity and an overall difference in β-diversity. Although no specific gut microbiota alterations were consistently reported, a gain in Enterococcus and a significant decrease in Anaerostipes, Blautia, Coprococcus, Faecalibacterium, Roseburia, Ruminococcus, and Lachnospira were found in the majority of the included articles. Moreover, there is insufficient data to show specific microbiota bacteria associated with disease activity, location, and behavior in pediatric IBD.Conclusions: This systematic review identified evidence for differences in the abundance of some bacteria in pediatric patients with IBD when compared to patients without IBD; however, no clear overall conclusion could be drawn from the included studies due to inconsistent results and heterogeneous methodologies. Further studies with large samples that follow more rigorous and standardized methodologies are needed.
Patagonin-CRISP: Antimicrobial Activity and Source of Antimicrobial Molecules in Duvernoy’s Gland Secretion (Philodryas patagoniensis Snake)
Authors: Badari Juliana Cuoco , Díaz-Roa Andrea , Teixeira Rocha Marisa Maria , Mendonça Ronaldo Zucatelli , Silva Junior Pedro Ismael da 
Published: February 2021

Snake venom contains a variety of toxins with a range of biological activity, among these toxins cysteine-rich secreted proteins (CRISPs) can be found. The proteins of this family have masses of 20–30 kDa and display homologous amino acid sequences containing 16 cysteine residues, forming eight disulfide bonds. Some of these proteins have been explored, characterized, and described in terms of their activity; however, little is known about their range of activities. A search for new antimicrobial molecules is ongoing, as the number of microbial strains resistant to available antibiotics is increasing. We identified antimicrobial activity in the secretion of Duvernoy's gland of the rear-fanged Philodryas patagoniensis. Fractions of this venom were subjected to reverse-phase high performance liquid chromatography and analyzed to determine their antimicrobial activity with a liquid broth inhibition assay. One of the fractions presented activity against a Gram-negative bacterium and a filamentous fungus. This fraction was analyzed with LC-MS/MS, and a protein of 24,848.8 Da was identified. Database searches allowed us to identify it as a CRISP due to the presence of some unique fragments in the molecule. We called it patagonin-CRISP, as the same protein in the venom of P. patagoniensis had previously been characterized as having a different biological activity. Patagonin-CRISP presented activity at very low concentrations and showed no cytotoxic activity. This is the first time that antimicrobial activity has been identified for P. patagoniensis venom or for a CRISP family protein.
Involvement of Circulating Exosomal MicroRNAs in Jian-Pi-Yi-Shen Formula Protection Against Adenine-Induced Chronic Kidney Disease
Authors: Liu Xinhui , Liu Siqi , Luo Denggui , Huang Shiying , Wang Fochang , Zhang Bing , Chen Yulian , Zheng Lin , Lu Jiandong , Li Shunmin 
Published: February 2021

Jian-Pi-Yi-Shen formula (JPYSF) is a traditional Chinese medicine (TCM) formula used in clinic to treat chronic kidney disease (CKD) for decades. However, the mechanisms of JPYSF in treating CKD have not been fully elucidated. The aim of the present study was to test the renoprotective effect of JPYSF on CKD rat model and investigate the potential mechanism from the perspective of serum exosomal microRNAs (miRNAs). CKD rat model was induced by feeding Sprague-Dawley rats a diet containing 0.75% w/w adenine for four weeks. The rats in the treatment group were given 10.89 g/kg JPYSF by gavage every day, starting from the 3rd week of the adenine-containing diet for six weeks. Serum biochemistry and histopathology were used to evaluate the renoprotective effects of JPYSF. Serum exosomes were isolated by ExoQuick-TC PLUS exosomes extraction kit and were identified by transmission electron microscopy, nanoparticle tracking analysis, and western blot. Exosomal miRNAs profiling was analyzed by small RNA sequencing. The results showed that JPYSF treatment significantly lowered serum creatinine and blood urea nitrogen levels and alleviated renal pathological injury in CKD rats. Furthermore, serum exosomes were successfully isolated and identified. Small RNA sequencing revealed that 4 exosomal miRNAs (miR-192-5p, miR-194-5p, miR-802-5p, and miR-143-3p) were significantly downregulated in the CKD group and were markedly upregulated after JPYSF treatment. At last, miR-192-5p was identified as the most relevant miRNA for CKD diagnosis and JPYSF treatment. In conclusion, JPYSF protects kidney from adenine-induced CKD, which may be associated with modulation of exosomal miRNAs.
Co-Therapy of Pegylated G-CSF and Ghrelin for Enhancing Survival After Exposure to Lethal Radiation
Authors: Kiang Juliann G. , Zhai Min , Lin Bin , Smith Joan T. , Anderson Marsha N. , Jiang Suping 
Published: February 2021

Exposure to ionizing radiation (radiation injury, RI) in nuclear-related episode is evident to be life-threatening. RI occurs at levels of organs, tissues, cytosols, or nucleus. Their mechanisms are still not fully understood. FDA approves pegylated granulocyte colony-stimulating factor (Neulasta™, Peg-G-CSF) for acute hematopoietic syndrome and has been shown to save lives after lethal RI. We aimed to test whether Ghrelin enhanced Peg-G-CSF’s efficacy to save more lives after lethal RI. B6D2F1/J female mice were used for the study. They received 9.5 Gy (LD50/30 at 0.4 Gy/min) emitted from the60Co-γ-photon radiation facility. Peg-G-CSF was injected subcutaneously at 1 mg/kg once on days 1, 8, and 15 after irradiation. Ghrelin contains 28 amino acid and is a hunger peptide that has been shown to stimulate food intake, promote intestinal epithelial cell proliferation, elevates immunity, inhibits brain hemorrhage, and increases stress-coping. Ghrelin was injected subcutaneously at 113 μg/kg once on days 1, 2, and 3 after irradiation. Survival, body weight, water consumption, hematology, spleen weight, splenocytes, bone marrow cells, and histology of bone marrow and ileum were performed. We observed that radiation resulted in 30-days survival by 30%. RI decreased their body weights and water consumption volumes. On the 30th day post-RI, platelets and WBCs such as basophils, eosinophils, monocytes, lymphocytes, neutrophils and leukocytes were still significantly decreased in surviving mice. Likewise, their RBC, hemoglobin, hematocrit, and splenocytes remained low; splenomegaly was found in these mice. Bone marrow in surviving RI animals maintained low cellularity with high counts of fat cells and low counts of megakaryocytes. Meanwhile, ileum histology displayed injury. However, mice co-treated with both drugs 24 h after RI resulted in 30-days survival by 45% above the vehicle group. Additionally, the body-weight loss was mitigated, the acute radiation syndrome was reduced. This co-therapy significantly increased neutrophils, eosinophils, leukocytes, and platelets in circulation, inhibited splenomegaly, and increased bone marrow cells. Histopathological analysis showed significant improvement on bone marrow cellularity and ileum morphology. In conclusion, the results provide a proof of concept and suggest that the co-therapy of Peg-G-CSF and Ghrelin is efficacious to ameliorate RI.
The Design and Development of a Personalized Leisure Time Physical Activity Application Based on Behavior Change Theories, End-User Perceptions, and Principles From Empirical Data Mining
Authors: Sporrel Karlijn , De Boer Rémi D. D. , Wang Shihan , Nibbeling Nicky , Simons Monique , Deutekom Marije , Ettema Dick , Castro Paula C. , Dourado Victor Zuniga , Kröse Ben 
Published: February 2021

Introduction: Many adults do not reach the recommended physical activity (PA) guidelines, which can lead to serious health problems. A promising method to increase PA is the use of smartphone PA applications. However, despite the development and evaluation of multiple PA apps, it remains unclear how to develop and design engaging and effective PA apps. Furthermore, little is known on ways to harness the potential of artificial intelligence for developing personalized apps. In this paper, we describe the design and development of the Playful data-driven Active Urban Living (PAUL): a personalized PA application.Methods: The two-phased development process of the PAUL apps rests on principles from the behavior change model; the Integrate, Design, Assess, and Share (IDEAS) framework; and the behavioral intervention technology (BIT) model. During the first phase, we explored whether location-specific information on performing PA in the built environment is an enhancement to a PA app. During the second phase, the other modules of the app were developed. To this end, we first build the theoretical foundation for the PAUL intervention by performing a literature study. Next, a focus group study was performed to translate the theoretical foundations and the needs and wishes in a set of user requirements. Since the participants indicated the need for reminders at a for-them-relevant moment, we developed a self-learning module for the timing of the reminders. To initialize this module, a data-mining study was performed with historical running data to determine good situations for running.Results: The results of these studies informed the design of a personalized mobile health (mHealth) application for running, walking, and performing strength exercises. The app is implemented as a set of modules based on the persuasive strategies “monitoring of behavior,” “feedback,” “goal setting,” “reminders,” “rewards,” and “providing instruction.” An architecture was set up consisting of a smartphone app for the user, a back-end server for storage and adaptivity, and a research portal to provide access to the research team.Conclusions: The interdisciplinary research encompassing psychology, human movement sciences, computer science, and artificial intelligence has led to a theoretically and empirically driven leisure time PA application. In the current phase, the feasibility of the PAUL app is being assessed.
Safety and Efficacy of Pancreaticoduodenectomy in Octogenarians
Authors: Huang Yeqian , Damodaran Prabha Ramesh , Chua Terence C. , Arena Jennifer , Kotecha Krishna , Mittal Anubhav , Gill Anthony J. , Samra Jaswinder S. 
Published: February 2021

Backgrounds: Pancreaticoduodenectomy (PD) remains the only hope of a cure in selected patients with pancreatic adenocarcinoma (PAC). With an aging population, there will be an increasing number of very elderly patients being diagnosed with PAC of whom a selected proportion would be suitable for PD. However, the literature on outcomes of elderly patients after PD remains ambiguous. Therefore, the aim of this study was to examine the safety and efficacy of PD in octogenarians with PAC.Methods: A retrospective analysis of 304 patients with PAC undergoing PD. Patients were divided into two age groups using age of 80 years old as the cut-off.Results: Overall mortality and major morbidity rates were 0.5 and 18.5%, respectively. The octogenarian group had a higher rate of mortality (6.3%, n = 1, p &lt; 0.001), a higher rate of major morbidity (37.5%, n = 6, p = 0.042) and a longer hospital stay (p = 0.035). However, median survival of octogenarians was 15.6 months. Multivariate analysis showed age was not identified as a prognostic factor for major morbidity and overall survival.Conclusion: Age alone should not be an exclusion criterion for consideration of PD. With careful selection, PD can be safely performed in octogenarians. Elderly patients should be referred to a specialized unit for an objective assessment to determine the suitability for this aggressive but potential curative approach.