bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transmission potential of FloridianAedes aegyptimosquitoes for dengue virus serotype 4: Implications for estimating local dengue risk
Authors: Stephenson Caroline J. , Coatsworth Heather , Kang Seokyoung , Lednicky John A. , Dinglasan Rhoel R. 
Published: March 2021

AbstractDengue virus serotype 4 (DENV-4) circulated inAedes aegyptiin 2016 and 2017 in Florida in the absence of human index cases, compelling a full assessment of local mosquito vector competence and DENV-4 risk. To better understand DENV-4 transmission risk in Florida, we used an expanded suite of tests to measure and compare the vector competence of both an established colony ofAe. aegypti(Orlando strain [ORL]) and a field-derived colony from Collier County, Florida in 2018 (COL) for a Haitian DENV-4 human field isolate and a DENV-4 laboratory strain (Philippines H241). We immediately noted that ORL saliva-positivity was higher for the field versus laboratory DENV-4 strains. In a subsequent comparison with the recent COL mosquito colony we also observed significantly higher midgut susceptibility of COL and ORL for the Haitian DENV-4 field strain, and significantly higher saliva-positivity rate for COL, although overall saliva virus titers were similar between the two. These data point to a potential midgut infection barrier for the DENV-4 laboratory strain for both mosquito colonies and that the marked difference in transmission potential estimates hinge on virus-vector combinations. Our study highlights the importance of leveraging an expanded suite of testing methods with emphasis on utilizing local mosquito populations and field relevant dengue serotypes and strains to accurately estimate transmission risk in a given setting.ImportanceDENV-4 was found circulating in Florida (FL)Ae. aegyptimosquitoes in the absence of human index cases in the state (2016-2017). How DENV-4 was maintained locally is unclear, presenting a major gap in our understanding of DENV-4 public health risk. We determined the baseline arbovirus transmission potential of laboratory and field colonies ofAe. aegyptifor both laboratory and field isolates of DENV-4. We observed high transmission potential of field populations ofAe. aegyptiand evidence of higher vertical transmission of the DENV-4 field isolate, providing clues to the possible mechanism of undetected DENV-4 maintenance in the state. Our findings also move the field forward in the development of best practices for evaluating arbovirus vector competence, with evidence that transmission potential estimates vary depending on the mosquito-virus combinations. These data emphasize the poor suitability of lab-established virus strains and the high relevance of field-derived mosquito populations in estimating transmission risk.
Rescue of two trafficking-defective variants of the neuronal glycine transporter GlyT2 associated to hyperekplexia
Authors: de la Rocha-Muñoz Andrés , Melgarejo Elena , Aragón Carmen , López-Corcuera Beatriz 
Published: March 2021

AbstractHyperekplexia is a rare sensorimotor syndrome characterized by pathological startle reflex in response to unexpected trivial stimuli for which there is no specific treatment. Neonates suffer from hypertonia and are at high risk of sudden death due to apnea episodes. Mutations in the humanSLC6A5gene encoding the neuronal glycine transporter GlyT2 may disrupt the inhibitory glycinergic neurotransmission and cause a presynaptic form of the disease. The phenotype of missense mutations giving rise to protein misfolding but maintaining residual activity could be rescued by facilitating folding or intracellular trafficking. In this report, we characterized the trafficking properties of two mutants associated with hyperekplexia (A277T and Y707C, rat numbering). Transporter molecules were partially retained in the endoplasmic reticulum showing increased interaction with the endoplasmic reticulum chaperone calnexin. One transporter variant had export difficulties and increased ubiquitination levels, suggestive of enhanced endoplasmic reticulum-associated degradation. However, the two mutant transporters were amenable to correction by calnexin overexpression. Within the search for compounds capable of rescuing mutant phenotypes, we found that the arachidonic acid derivative N-arachidonoyl glycine can rescue the trafficking defects of the two variants in heterologous cells and rat brain cortical neurons. N-arachidonoyl glycine improves the endoplasmic reticulum output by reducing the interaction transporter/calnexin, increasing membrane expression and improving transport activity in a comparable way as the well-established chemical chaperone 4-phenyl-butyrate. This work identifies N-arachidonoyl glycine as a promising compound with potential for hyperekplexia therapy.
Calcium-Permeable AMPA Receptor Activity and GluA1 Trafficking in the Basolateral Amygdala Regulate the Positive Reinforcing Effects of Alcohol
Authors: Faccidomo Sara , Cogan Elizabeth S , Hon Olivia J. , Hoffman Jessica L , Saunders Briana L , Eastman Vallari R , Kim Michelle , Taylor Seth M. , A McElligott Zoé , Hodge Clyde W 
Published: March 2021

AbstractAddiction is viewed as maladaptive glutamate-mediated neuroplasticity that is regulated, in part, by calcium-permeable AMPA receptor (CP-AMPAR) activity. However, the contribution of CP-AMPARs to alcohol-seeking behavior remains to be elucidated. We evaluated CP-AMPAR activity in the basolateral amygdala (BLA) as a potential target of alcohol that also regulates alcohol self-administration in C57BL/6J mice. Operant self-administration of sweetened alcohol increased spontaneous EPSC frequency in BLA neurons that project to the nucleus accumbens as compared to behavior-matched sucrose controls indicating an alcohol-specific upregulation of synaptic activity. Bath application of the CP-AMPAR antagonist NASPM decreased evoked EPSC amplitude only in alcohol self-administering mice indicating alcohol-induced synaptic insertion of CP-AMPARs in BLA projection neurons. Moreover, NASPM infusion in the BLA dose-dependently decreased the rate of operant alcohol self-administration providing direct evidence for CP-AMPAR regulation of alcohol reinforcement. Since most CP-AMPARs are GluA1-containing, we asked if alcohol alters the activation state of GluA1-containing AMPARs. Immunocytochemistry results showed elevated GluA1-S831 phosphorylation in the BLA of alcohol as compared to sucrose mice. To investigate mechanistic regulation of alcohol self-administration by GluA1-containing AMPARs, we evaluated the necessity of GluA1 trafficking using a TET-ON AAV encoding a dominant-negative GluA1 c-terminus (GluA1ct) that blocks activity-dependent synaptic delivery of native GluA1-containing AMPARs. GluA1ct expression in the BLA reduced alcohol self-administration with no effect on sucrose controls. These results show that CP-AMPAR activity and GluA1 trafficking in the BLA mechanistically regulate the reinforcing effects of sweetened alcohol. Pharmacotherapeutic targeting these mechanisms of maladaptive neuroplasticity may aid medical management of alcohol use disorder.
Geometric properties of the Bertotti–Kasner space-time
Authors: Manjunatha H.M. , Narasimhamurthy S.K. , Nekouee Zohreh 
Published: March 2021

PurposeThe purpose of this paper is to study the Bertotti–Kasner space-time and its geometric properties.Design/methodology/approachThis paper is based on the features of λ-tensor and the technique of six-dimensional formalism introduced by Pirani and followed by W. Borgiel, Z. Ahsan et al. and H.M. Manjunatha et al. This technique helps to describe both the geometric properties and the nature of the gravitational field of the space-times in the Segre characteristic.FindingsThe Gaussian curvature quantities specify the curvature of Bertotti–Kasner space-time. They are expressed in terms of invariants of the curvature tensor. The Petrov canonical form and the Weyl invariants have also been obtained.Originality/valueThe findings are revealed to be both physically and geometrically interesting for the description of the gravitational field of the cylindrical universe of Bertotti–Kasner type as far as the literature is concerned. Given the technique of six-dimensional formalism, the authors have defined the Weyl conformal λW-tensor and discussed the canonical form of the Weyl tensor and the Petrov scalars. To the best of the literature survey, this idea is found to be modern. The results deliver new insight into the geometry of the nonstatic cylindrical vacuum solution of Einstein's field equations.
Management control structures and performance implications in international construction joint ventures: critical survey and conceptual framework
Authors: Tetteh Mershack Opoku , Chan Albert P.C. , Ameyaw Ernest Effah , Darko Amos , Yevu Sitsofe Kwame , Boateng Emmanuel B. 
Published: March 2021

PurposeManagement control is needed in international joint ventures (IJVs) for successful management and performance. While IJV management control and performance concept has been widely explored, in the construction sector, the core understanding of the design of the two concepts is still lacking. This has resulted in the neglect of important questions and directions for research and practice improvement. This study aims to conduct a critical survey of prior studies addressing the conceptualization of management control and performance in IJVs and to propose a framework for studying the performance implications of management control in international construction joint ventures (ICJVs).Design/methodology/approachUsing Scopus database and search terms, a systematic desktop search was conducted to retrieve empirically related peer-reviewed papers for this study.FindingsDrawing on the transaction cost, institutional and relational logic, the first inclusive hypothetical model for studying the relationship between different dimensions of management control mechanism and multiple performance criteria in ICJVs is presented. The model proposes a measurement method for both the management control and performance and explains how they can be established in ICJVs.Practical implicationsThe proposed framework provides a methodology to understand the dynamics of management control and performance implications in ICJV. Specifically, uncovering the critical paths will assist ICJV frontliners to approach management control in a more holistic and systematic way to promote achievement of ICJV goals.Originality/valueThe study gives a firm ground to the construction industry, which is accurate and educational for related fields concentrating on several other forms of cooperative relationships.
Technological foresight as support for the planning of research and development centers: the case of EI-UNAM
Authors: Castillo-Camarena Nadia , López-Ortega Eugenio 
Published: March 2021

Purpose
This study aims to present a method to carry out technological foresight exercises in university technological research and development centers (TRDCs). The results support the organizational planning process.

Design/methodology/approach
The authors review the literature on the frameworks of foresight. The authors propose the use of quantitative (bibliometrics) and qualitative (expert meeting, Delphi) techniques. The authors apply this method to each research topic of interest of the TRDCs.

Findings
The application of the method to a research topic allows us to analyze the relevant knowledge areas for the development of that topic and its global trend. For each area, the authors identify the specific lines of research with the greatest growth and relevance. Considering these lines, the authors make a diagnosis of the TRDC situation regarding how to provide knowledge to decision-makers.

Research limitations/implications
The paper reviews the results of the application in the Engineering Institute of the National Autonomous University of Mexico and in the research topic “Seismic risks in civil engineering.” It is necessary to adjust the application of the method in other TRDCs to the conditions of the organization and to the development achieved by the TRDCs in the analyzed research topic.

Originality/value
There is no detailed literature on technological foresight exercises in university TRDCs that support the planning process of the organization. The method represents a proposal to establish priority research topics and specific research lines in research institutes, particularly universities. The authors present the application in a university TRDCs in Mexico.
Idea plagiarism detection with recurrent neural networks and vector space model
Authors: Nazir Azra , Mir Roohie Naaz , Qureshi Shaima 
Published: March 2021

PurposeNatural languages have a fundamental quality of suppleness that makes it possible to present a single idea in plenty of different ways. This feature is often exploited in the academic world, leading to the theft of work referred to as plagiarism. Many approaches have been put forward to detect such cases based on various text features and grammatical structures of languages. However, there is a huge scope of improvement for detecting intelligent plagiarism.Design/methodology/approachTo realize this, the paper introduces a hybrid model to detect intelligent plagiarism by breaking the entire process into three stages: (1) clustering, (2) vector formulation in each cluster based on semantic roles, normalization and similarity index calculation and (3) Summary generation using encoder-decoder. An effective weighing scheme has been introduced to select terms used to build vectors based on K-means, which is calculated on the synonym set for the said term. If the value calculated in the last stage lies above a predefined threshold, only then the next semantic argument is analyzed. When the similarity score for two documents is beyond the threshold, a short summary for plagiarized documents is created.FindingsExperimental results show that this method is able to detect connotation and concealment used in idea plagiarism besides detecting literal plagiarism.Originality/valueThe proposed model can help academics stay updated by providing summaries of relevant articles. It would eliminate the practice of plagiarism infesting the academic community at an unprecedented pace. The model will also accelerate the process of reviewing academic documents, aiding in the speedy publishing of research articles.
Fuzzy-logic-based support tools for initial screening of manufacturing reshoring decisions
Authors: Hilletofth Per , Sequeira Movin , Tate Wendy 
Published: March 2021

PurposeThis paper investigates the suitability of fuzzy-logic-based support tools for initial screening of manufacturing reshoring decisions.Design/methodology/approachTwo fuzzy-logic-based support tools are developed together with experts from a Swedish manufacturing firm. The first uses a complete rule base and the second a reduced rule base. Sixteen inference settings are used in both of the support tools.FindingsThe findings show that fuzzy-logic-based support tools are suitable for initial screening of manufacturing reshoring decisions. The developed support tools are capable of suggesting whether a reshoring decision should be further evaluated or not, based on six primary competitiveness criteria. In contrast to existing literature this research shows that it does not matter whether a complete or reduced rule base is used when it comes to accuracy. The developed support tools perform similarly with no statistically significant differences. However, since the interpretability is much higher when a reduced rule base is used and it require fewer resources to develop, the second tool is more preferable for initial screening purposes.Research limitations/implicationsThe developed support tools are implemented at a primary-criteria level and to make them more applicable, they should also include the sub-criteria level. The support tools should also be expanded to not only consider competitiveness criteria, but also other criteria related to availability of resources and strategic orientation of the firm. This requires further research with regard to multi-stage architecture and automatic generation of fuzzy rules in the manufacturing reshoring domain.Practical implicationsThe support tools help managers to invest their scarce time on the most promising reshoring projects and to make timely and resilient decisions by taking a holistic perspective on competitiveness. Practitioners are advised to choose the type of support tool based on the available data.Originality/valueThere is a general lack of decision support tools in the manufacturing reshoring domain. This paper addresses the gap by developing fuzzy-logic-based support tools for initial screening of manufacturing reshoring decisions.
The nexus between foreign bank presence and credit to the private sector: evidence from Sub-Saharan Africa
Authors: Fiador Vera , Amoah Lordina , Abbey Emmanuel 
Published: March 2021

PurposeThe purpose of the study is to explore the implications of global financial integration on host economies in Sub-Saharan Africa (SSA). The study tests the competing views on the impact of foreign bank penetration on private sector access to credit in developing host economies.Design/methodology/approachUsing data on a panel 25 SSA economies over a period of 22 years from 1995 to 2016, the study employs fixed effects and Prais-Winsten estimations as well as generalized methods of moments (GMM) to test the foreign bank impact.FindingsThe findings show support for the hypothesis that global financial integration has positive implications for participating economies. In other words, financial sector liberalization and deregulation leading to the influx of foreign banks has positive implications for access to credit by the private sector in SSA economies. The study also finds other standard determinants of access to credit like lending rate and broad money supply conforming to the existing literature in terms of impact.Originality/valueOverall, the findings hold relevant implications for banking sector policies and the financial sector in general regarding the priority that policy makers and advisors attach to reforming financial sector policies.
Design and evaluation of exoskeleton for static conditions using Indian anthropometric considerations
Authors: C.R. Abhilash , Murali Sriraksha , Haq M. Abdul , Narahari N.S. 
Published: March 2021

Purpose
Various occupations in life require personnel to stand for a prolonged period of time. This causes excessive stress on the joints leading to musculoskeletal disorders. This paper aims to design an equipment ensure the personnel rests on whenever necessary.

Design/methodology/approach
The method followed in this paper is the adoption of Karl Ulrich’s product design methodology with suitable modifications as per requirement. Human anthropometric data from the Indian population has been considered during the design and modelled according to it using computer aided design and computer aided engineering tools.

Findings
The conceptual equipment – exoskeleton designed sustained loads of human beings and proved to be a safe design in terms of the strength of the material used in the design.

Social implications
This design can serve as equipment, which helps the personnel with long-standing work hours to relieve themselves without actually sitting.

Originality/value
The design has been carefully crafted based on the inputs from the anthropometric features of human beings, which is completely passive in nature i.e. no use of external power is required for this exoskeleton compared to the other available designs.
Investigating the determinants and process of destination management system (DMS) implementation
Authors: Le Anh T. P. , Kunasekaran Puvaneswaran , Rasoolimanesh S. Mostafa , AriRagavan Neethiahnanthan , Thomas Toney K. 
Published: March 2021

Purpose
This study aims to propose a comprehensive model to help understand factors influencing the intention to participate in a destination management system (DMS) amongst tourism stakeholders in Vietnam which are considered as the determinants of the successful implementation of the system.

Design/methodology/approach
A survey was conducted to investigate key stakeholders' opinions of participating in a DMS. In total, 301 questionnaires were used for analysis. Partial least squares structural equation modelling (PLS-SEM) was used to assess the measurement and structural models of the study.

Findings
Factors that influence various tourism stakeholders' intention to participate in the national DMS in Vietnam have been identified and examined. The results identify the important predictors of the tourism stakeholders' participation in the DMS including information quality, DMS operator readiness, government regulations and technology awareness. Interestingly, technology awareness was ascertained as a significant mediator for the relationship between performance expectancy, social influence, technology competency, competitive pressure and the intention to participate in the DMS.

Originality/value
This study has a unique theoretical contribution by developing a comprehensive model to predict the intention to participate in a DMS amongst tourism stakeholders with the modification and combination of three theoretical models and frameworks: the unified theory of acceptance and use of technology (UTAUT) model, technology–organisation–environment (TOE) framework and updated DeLone and McLean information systems (D&M IS) success model. It is expected to be a useful reference source for tourism management departments that want to develop DMSs in Vietnam. This model also can be used as an initial investigation for DMS implementation studies at other destinations.
Mutual monitoring in multi-period teams: an experimental investigation
Authors: Nikias Anthony , Sy Aida 
Published: March 2021

Purpose
The purpose of this paper is to examine whether managers punish more and work harder in teams with peer monitoring when it is less costly to punish in a two-period, one-shot horizon.

Design/methodology/approach
An experiment is conducted in a two-period horizon with two treatments. The structure of performance measures makes it costless or costly to punish in the second period.

Findings
The results find punishing, contingent on first-period strategies, was significantly greater when it was costless compared to costly, as expected. Working, which is analogous to cooperating in prisoner dilemma games, was also significantly greater in the first and second periods when punishing was costless.

Practical implications
This paper is informative about the potential benefits of performance measures in dynamic team environments, which can be challenging and costly to develop. It adds insight into the design of self-discipline and tasks in teams which might help increase productivity.

Originality/value
This paper is related to the research on indefinite horizons, which attributes increases in cooperation to the existence of subgame perfect strategies to cooperate and potential gains from future cooperation. In comparison, this study examines the effects of the existence of subgame perfect strategies to work in isolation from the potential gains from future interactions. In addition, it examines whether their potential benefits depend on the cost of punishing when punishing is subgame perfect in a one-shot horizon.