bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trans-basin influence of southwest tropical Indian Ocean warming during early boreal summer
Authors: Chen Zesheng , Li Zhenning , Du Yan , Wen Zhiping , Wu Renguang , Xie Shang-Ping 
Published: September 2021

AbstractThis study examines the climate response to a sea surface temperature (SST) warming imposed over the southwest Tropical Indian Ocean (TIO) in a coupled ocean-atmosphere model. The results indicate that the southwest TIO SST warming can remotely modulate the atmospheric circulation over the western North Pacific (WNP) via inter-basin air-sea interaction during early boreal summer. The southwest TIO SST warming induces a “C-shaped” wind response with northeasterly and northwesterly anomalies over the north and south TIO, respectively. The northeasterly wind anomalies contribute to the north TIO SST warming via a positive Wind-Evaporation-SST(WES) feedback after the Asian summer monsoon onset. In June, the easterly wind response extends into the WNP, inducing an SST cooling by WES feedback on the background trade winds. Both the north TIO SST warming and the WNP SST cooling contribute to an anomalous anticyclonic circulation (AAC) over the WNP. The north TIO SST warming, WNP SST cooling, and AAC constitute an inter-basin coupled mode called the Indo-western Pacific ocean capacitor (IPOC), and the southwest TIO SST warming could be a trigger for IPOC. While the summertime southwest TIO SST warming is often associated with antecedent El Niño, the warming in 2020 seems to be related to extreme Indian Ocean Dipole in 2019 fall. The strong southwest TIO SST warming seems to partly explain the strong summer AAC of 2020 over the WNP even without a strong antecedent El Niño.
Promoting and Protecting Mental Health: A Delphi Consensus Study for Actionable Public Mental Health Messages
Authors: Breedvelt Josefien J. F. , Yap Jade , Eising Dorien D. , Ebert David D. , Smit Filip , Thorpe Lucy , Kousoulis Antonis A. 
Published: September 2021

Purpose: Public health campaigns are still relatively rare in mental health. This paper aims to find consensus on the preventive self-management actions (i.e. “healthy behaviors”) for common mental health problems (e.g. depression and anxiety) that should be recommended in mental health campaigns directed at the general public. Approach: A 3-round Delphi study Participants: 23 international experts in mental health and 1447 members of the public, most of whom had lived experience of mental health problems. Method: The modified Delphi study combined quantitative and qualitative data collection: 1) online qualitative survey data collection thematically analyzed, 2) recommendations rated for consensus, 3) consensus items rated by public panel on a Likert scale. Results: Expert consensus was reached on 15 behaviors that individuals can engage in to sustain mental health. Eight were rated as appropriate by more than half (50%) of the public panel, including: avoiding illicit drugs (80%, n = 1154), reducing debt (72%, n = 1043), improving sleep (69%, n = 1000), regulating mood (65%, n = 941), having things to look forward to (60%, n = 869). Conclusions: A series of healthy behaviors for the promotion and protection of mental health received expert and public consensus. To our knowledge, this is the first study to offer a set of actions for public health messaging for the prevention of poor mental health. Future research should focus on evaluating effectiveness of these actions in a universal primary prevention context.
Three-Dimensional Computed Tomography Bronchography and Angiography-Guided Thoracoscopic Segmentectomy for Pulmonary Nodules
Authors: Hu Cheng-guang , Yang Xiao-tang , Zhao Ming , Zheng Kang , Li Zhi-long , Liu Guan-hua , Zhao Yan-li , Lian Jian-hong , Guo Shi-ping 
Published: September 2021

Background Three-dimensional computed tomography bronchography and angiography (3D-CTBA) provides detailed imaging information for pulmonary segmentectomy. This study was performed to verify the feasibility of 3D-CTBA-guided thoracoscopic segmentectomy for the treatment of pulmonary nodules. Methods A retrospective analysis was performed on all patients who underwent 3D-CTBA-guided uniport thoracoscopic segmentectomies or subsegmentectomies for pulmonary nodules in the period from May 2019 to May 2020. All of the information related to perioperative management and surgical operations was retrieved from the medical records and operating notes for detailed analysis. Results A total of 104 eligible operations involving the resection of 110 nodules with diameters in the range of 5-20 mm were included. Under 3D-CTBA guidance, the pulmonary nodules were located with an accuracy of 100% (110/110) and the median resection margin was 24.3 mm (17-33 mm). Additionally, the segmental (subsegmental) bronchi, arteries, and veins were identified with accuracy rates of 100% (104/104), 96.2% (100/104), and 94.2% (98/104), respectively. The postoperative complications consisted of 3 cases of pulmonary infection (2.9%), 6 cases of arrhythmia (5.8%), 2 cases of hemoptysis (1.9%), 4 cases of air leak (3.8%), and 2 cases of subcutaneous emphysema (1.9%). No perioperative death occurred. Conclusion 3D-CTBA-guided thoracoscopic segmentectomy is an effective surgical approach for the management of pulmonary nodules.
Magnetic resonance imaging quantitative T2* mapping to predict the red blood cell content of in vivo thrombi retrieved from patients with large vessel occlusions in acute ischemic stroke
Authors: Gilbert Alize , Detraz Lili , Alexandre Pierre-Louis , Serfaty Jean-Michel , Desal Hubert , Toquet Claire , Bourcier Romain 
Published: September 2021

Background and purpose Magnetic resonance imaging quantitative T2* mapping has shown reliable identification of thrombus red blood cell content in vitro. The thrombus composition has been in vivo, associated with outcomes after endovascular therapy for acute ischemic stroke. We aim to analyze the red blood cell content of thrombi retrieved from patients with large vessel occlusions in relation to the thrombus-T2* relaxation time in magnetic resonance imaging. Material and methods Consecutive acute ischemic stroke patients treated by endovascular therapy were scanned with an magnetic resonance imaging quantitative T2* mapping sequence. Quantitative histologic evaluations of red blood cell content were performed. A linear regression assessed the association between vascular risk factors, comorbidities, antithrombotic drugs intake, baseline National Institutes of Health Stroke Scale (NIHSS), intravenous thrombolysis before endovascular therapy, time between onset and groin puncture, patient's outcome at 3 months, magnetic resonance imaging quantitative T2* mapping results, and the red blood cell content of thrombi. The correlation between the mean thrombus-T2* relaxation time and red blood cell content was assessed by calculating the Pearson correlation coefficient. Results Among 31 thrombi, 16 were “Fibrin rich” and 15 “red blood cell dominant.” The median red blood cell content was 39 (range, 0–90; interquartile range, 37). The median (interquartile range) thrombus-T2* relaxation time was shorter in “red blood cell dominant” thrombi (21, interquartile range 6) than in “Fibrin rich” thrombi (24, interquartile range 7), without significant difference ( p = 0.15), as shown in the Box plot. An inverse correlation between thrombus-T2* relaxation time and red blood cell content was found, with a correlation coefficient of −0.41 (95% CI, −0.67 to −0.08, p = 0.02). Conclusion Our study shows that a shorter thrombus-T2* relaxation time is related to a higher red blood cell content within in vivo thrombi.
Magnitude and factors associated with anemia among pregnant women admitted to labor ward of Hiwot Fana Specialized University Hospital, Eastern Ethiopia
Authors: Abdu Serkalem , Ali Tilahun , Debella Adera , Assefa Nega , Teji Roba Kedir 
Published: September 2021

Objectives: Anemia is a common medical problem among pregnant women that will influence pregnancy and birth outcomes. In Ethiopia, there is a paucity of evidences regarding the problem among pregnant women admitted to labor ward. Therefore, the objective of this study was to assess the magnitude and factors associated with anemia among pregnant women admitted to labor ward for deliveries at Hiwot Fana Specialized University Hospital, Eastern Ethiopia. Methods: A cross-sectional study was conducted among 314 pregnant women admitted to labor ward at Hiwot Fana Specialized University Hospital in June 2020. Data were collected using an interviewer administered questionnaire and were entered into EpiData and analyzed using SPSS. Descriptive statistics and multiple logistic regression analysis were done to identify predictors of anemia. Results: In this study, the magnitude of anemia was 37.9% (95% confidence interval: 32.4, 43.0). Short birth interval (adjusted odds ratio = 2.5; 95% confidence interval: 1.02, 6.13), history of blood loss during pregnancy (adjusted odds ratio = 4.3; 95% confidence interval: 1.86, 9.9), less consumption of citrus fruit within a week (adjusted odds ratio = 2.9; 95% confidence interval: 1.2, 6.9), and meal frequency less than three times per day during pregnancy (adjusted odds ratio = 2.2; 95% confidence interval: 1.0, 4.6) were significantly associated with anemia, respectively. Conclusion: This study pointed out that more than one-third of pregnant women affected by anemia. Thus, interventions that could reduce anemia, such as counseling about increasing of meal frequency during pregnancy, foods rich in iron, and prevention and management of blood loss are recommended.
Communism and the Christian Response
Authors: Bates M. Searle 
Published: September 2021

This List of Readings succeeds those published on the same subject which were developed by the Missionary Study Fellowship on Christianity and Communism and were published in the Occasional Bulletin, Vol. II, No. 7 (August 1, 1951) and Vol, III, No. 6 (June 12, 1952). Since the Study Fellowship ceased in 1953, we have asked Dr. M. Searle Bates, Professor of Missions in Union Theological Seminary, to prepare an up-to-date list which would meet requests frequently received. Professor Bates long taught history, including a course in Russian History, in the University of Nanking and, since 1950, he has been carrying the Russian, East European, and Asian factors in the Seminary ocurse on Communism and Christianity, associated with Professors Reinhold Nisbuhr and John C. Bennett. He also worked with the Missionary Study Fellowship from 1951 to 1953. The enormous field of “Christian alternatives to Communism” has had to be left aside, for the most part, since the range of materials on democracy, liberty, economic progress, improvement of government, and social reform of every sort, knows no bounds. Certain chapters in general bocks, of course, are relevant to such issues.–Ed.
Intracellular hydroxyproline imprinting following resolution of bleomycin-induced pulmonary fibrosis
Authors: Song Shengren , Fu Zhenli , Guan Ruijuan , Zhao Jie , Yang Penghui , Li Yang , Yin Hang , Lai Yunxin , Gong Gencheng , Zhao Simin , Yu Jiangtian , Peng Xiaomin , He Ying , Luo Yumei , Zhong Nanshan , Su Jin 
Published: September 2021

BackgroundIdiopathic pulmonary fibrosis (IPF) is a fatal lung disease with few treatment options. The poor success in developing anti-IPF strategies has impelled researchers to reconsider the importance of the choice of animal model and assessment methodologies. Currently, it is still not settled whether the bleomycin-induced lung fibrosis mouse model finally returns to resolution.MethodsThis study aimed to follow the dynamic fibrotic features of bleomycin-treated mouse lungs over extended durations through a combination of the latest technologies (micro-computed tomography imaging and histological detection of degraded collagens) and traditional methods. In addition, we also applied immunohistochemistry to explore the distribution of all hydroxyproline-containing molecules.ResultsAs determined by classical biochemical methods, total lung hydroxyproline contents reached a peak at 4 weeks after bleomycin injury and maintained a steady high level thereafter until the end of the experiments (16 weeks). This result seemed to partially contradict with the changes of other fibrosis evaluation parameters, which indicated a gradual degradation of collagens and a recovery of lung aeration after the fibrosis peak. This inconsistency was well reconciled by our data from immunostaining against hydroxyproline and fluorescent peptide staining against degraded collagen, together showing large amounts of hydroxyproline-rich degraded collagen fragments detained and enriched within the intracellular regions at 10 or 16 weeks rather than at 4 weeks after bleomycin treatment.ConclusionsOur present data not only offer respiratory researchers a new perspective towards the resolution nature of mouse lung fibrosis, but also remind them to be cautious when using the hydroxyproline content assay to evaluate the severity of fibrosis.
In vitroandin vivomodulation of NADPH oxidase activity and reactive oxygen species production in human neutrophils by α1-antitrypsin
Authors: Hawkins Padraig , McEnery Thomas , Gabillard-Lefort Claudie , Bergin David A. , Alfawaz Bader , Shutchaidat Vipatsorn , Meleady Paula , Henry Michael , Coleman Orla , Murphy Mark , McElvaney Noel G. , Reeves Emer P. 
Published: September 2021

Oxidative stress from innate immune cells is a driving mechanism that underlies COPD pathogenesis. Individuals with α-1 antitrypsin (AAT) deficiency (AATD) have a dramatically increased risk of developing COPD. To understand this further, the aim of this study was to investigate whether AATD presents with altered neutrophil NADPH oxidase activation, due to the specific lack of plasma AAT.Experiments were performed using circulating neutrophils isolated from healthy controls and individuals with AATD. Superoxide anion (O2−) production was determined from the rate of reduction of cytochrome c. Quantification of membrane NADPH oxidase subunits was performed by mass spectrometry and Western blot analysis. The clinical significance of ourin vitrofindings was assessed in patients with AATD and severe COPD receiving intravenous AAT replacement therapy.In vitro, AAT significantly inhibited O2−production by stimulated neutrophils and suppressed receptor stimulation of cyclic adenosine monophosphate and extracellular signal-regulated kinase (ERK)1/2 phosphorylation. In addition, AAT reduced plasma membrane translocation of cytosolic phox components of the NADPH oxidase.Ex vivo, AATD neutrophils demonstrated increased plasma membrane-associated p67phoxand p47phoxand significantly increased O2−production. The described variance in phox protein membrane assembly was resolved post-AAT augmentation therapyin vivo, the effects of which significantly reduced AATD neutrophil O2−production to that of healthy control cells.These results expand our knowledge on the mechanism of neutrophil-driven airways disease associated with AATD. Therapeutic AAT augmentation modified neutrophil NADPH oxidase assembly and reactive oxygen species production, with implications for clinical use in conditions in which oxidative stress plays a pathogenic role.
Identification of driver genes based on gene mutational effects and network centrality
Authors: Tang Yun-Yun , Wei Pi-Jing , Zhao Jian-ping , Xia Junfeng , Cao Rui-Fen , Zheng Chun-Hou 
Published: September 2021

AbstractBackgroundAs one of the deadliest diseases in the world, cancer is driven by a few somatic mutations that disrupt the normal growth of cells, and leads to abnormal proliferation and tumor development. The vast majority of somatic mutations did not affect the occurrence and development of cancer; thus, identifying the mutations responsible for tumor occurrence and development is one of the main targets of current cancer treatments.ResultsTo effectively identify driver genes, we adopted a semi-local centrality measure and gene mutation effect function to assess the effect of gene mutations on changes in gene expression patterns. Firstly, we calculated the mutation score for each gene. Secondly, we identified differentially expressed genes (DEGs) in the cohort by comparing the expression profiles of tumor samples and normal samples, and then constructed a local network for each mutation gene using DEGs and mutant genes according to the protein–protein interaction network. Finally, we calculated the score of each mutant gene according to the objective function. The top-ranking mutant genes were selected as driver genes. We name the proposed method as mutations effect and network centrality.ConclusionsFour types of cancer data in The Cancer Genome Atlas were tested. The experimental data proved that our method was superior to the existing network-centric method, as it was able to quickly and easily identify driver genes and rare driver factors.
Psychiatric emergency admissions during and after COVID-19 lockdown: short-term impact and long-term implications on mental health
Authors: Ambrosetti Julia , Macheret Laura , Folliet Aline , Wullschleger Alexandre , Amerio Andrea , Aguglia Andrea , Serafini Gianluca , Prada Paco , Kaiser Stefan , Bondolfi Guido , Sarasin François , Costanza Alessandra 
Published: September 2021

Abstract
Background
The ‘lockdown’ measures, adopted to restrict population movements in order to help curb the novel coronavirus disease 2019 (COVID-19) pandemic, contributed to a global mental health crisis. Although several studies have extensively examined the impact of lockdown measures on the psychological well-being of the general population, little is known about long-term implications. This study aimed to identify changes in psychiatric emergency department (ED) admissions between two 8-week periods: during and immediately after lifting the lockdown.

Methods
Socio-demographic and clinical information on 1477 psychiatric ED consultations at the University Hospital of Geneva (HUG) were retrospectively analyzed.

Results
When grouped according to admission dates, contrary to what we expected, the post-lockdown group presented with more severe clinical conditions (as measured using an urgency degree index) compared to their lockdown counterparts. Notably, after the lockdown had been lifted we observed a statistically significant increase in suicidal behavior and psychomotor agitation and a decrease in behavior disorder diagnoses. Furthermore, more migrants arrived at the HUG ED after the lockdown measures had been lifted. Logistic regression analysis identified diagnoses of suicidal behavior, behavioral disorders, psychomotor agitation, migrant status, involuntary admission, and private resident discharge as predictors of post-lockdown admissions.

Conclusions
Collectively, these findings can have implications concerning the prioritization of mental health care facilities and access for patients at risk of psychopathological decompensation in time of confinement policies, but above all, provide a foundation for future studies focusing on the long-term impact of the pandemic and its associated sanitary measures on mental health.

Trial registration
Research Ethics Committee of Geneva, Registration number 2020–01510, approval date: 29 June 2020.
Arthroscopic findings and treatment of maisonneuve fracture complex
Authors: Fraissler Lukas , Mattiassich Georg , Brunnader Lars , Holzer Lukas A. 
Published: September 2021

Abstract
Background
The Maisonneuve fracture complex (MFC) is a well-known lower leg injury. However, the optimal treatment is still not clear and there is limited data on concomitant injuries of cartilage. Therefore, the aim of our study was to report the incidence of incidental cartilage injuries and their management in arthroscopic treatment of MFC.

Patients and methods
Between February 2018 and February 2021 all patients presenting with MFC in our department were treated with diagnostic ankle arthroscopy and percutaneous syndesmotic screw or suture-endobutton fixation. In case of instable cartilage, it was debrided and according to the International Consensus Meeting on Cartilage Repair of the Ankle, in grade IV lesions < 10 mm or < 100 mm2 area the subchondral bone was microfractured.

Results
Eighteen patients, 16 male and two female, with a mean age of 48.1 years, were included. In all cases, instability of the distal tibiofibular articulation was confirmed arthroscopically. Injuries of the cartilage were found in 56% of the cases and in 31% of the patients surgical intervention was required. In three talar and one tibial lesion additional arthroscopic bone marrow stimulation with microfracture of the subchondral bone was performed.

Conclusions
Ankle arthroscopy is a helpful method to guide fibular reduction and to detect and address associated cartilage injuries. Due to the high rate of chondral lesions, addressing these arthroscopically may contribute to better postoperative results.

Level of evidence
IV
Cytotoxicity, anti-angiogenic, anti-tumor and molecular docking studies on phytochemicals isolated from Polygonum hydropiper L.
Authors: Mahnashi Mater H. , Alqahtani Yahya S. , Alyami Bandar A. , Alqarni Ali O. , Ullah Farhat , Wadood Abdul , Sadiq Abdul , Shareef Azam , Ayaz Muhammad 
Published: September 2021

Abstract
Background
According to the recent global cancer statistics, breast cancer is the leading cause of deaths among women with 2.3 million new cases globally. Likewise, cervical cancer is also among the leading causes of mortality among women. Polygonum hydropiper is traditionally known for its cytotoxic effects and several bioactive cytotoxic compounds were isolated from it. This study was aimed to isolate potential anticancer compounds from its most potent fractions and evaluate their anticancer potentials.

Methods
Based on our earlier studies, active fractions including chloroform and ethyl acetate were subjected to column chromatography for isolation of compounds. Chemical structures of isolated compounds were confirmed via 1H NMR, 13C NMR, mass spectrometry. Purified compounds were tested for cytotoxicity against breast cancer cells (MCF-7), cervical cancer cells (HeLA) and NIH/3T3 fibroblasts cells cultures using MTT assy. Anti-angiogenic potentials of isolated compounds were evaluated via chorioallantoic membrane assay. Anti-tumor studies were done using Agrobacterium tumefaciens induced potato tumor assay. Furthermore, to understand the binding modes of Isolated compounds, molecular docking was performed against EGFR, HER2 and VEGFR using MOE as docking software.

Results
Two bioactive compounds PH-1 (4-methyl-5-oxo-tetrahydrofuran-3-yl acetate) and PH-2 (methyl 4-hydroxy-3-methoxybenzoate) were purified from the active fractions. In cytotoxicity studies, PH-1 exhibited highest cytotoxicity against HeLA cells with 87.50% lethality at 1 mgmL−1 concentration and LD50 of 60 µgmL−1. Likewise, PH-2 showed 82.33% cytotoxicity against HeLA cells with LD50 of 160 µgmL−1. Similarly, PH-1 and PH-2 exhibited LD50 of 170 and 380 µgmL−1 respectively. Moreover, PH-1 and PH-2 were also very potent cytotoxic compounds against NIH/3T3 cells with 81.45 and 85.55% cytotoxicity at 1 mgL−1 concentration and LD50 of 140 and 58 µgL−1 respectively. Isolated compounds exhibited considerable anti-angiogenic potentials with IC50 of 340 and 500 µgL−1 respectively for PH-1 and PH-2. In anti-tumor assay, PH-1 and PH-2 exhibited 81.15 and 76.09% inhibitions with LD50 of 340 and 550 µgL−1 respectively. Both compounds selectively binds with EGFR and HER2 receptors with low binding energies. Both compounds exhibited stronger interactions with VEGFR through binding pocket residues Lys868, Val916 and Asp1046.

Conclusions
Both compounds cause considerable cytotoxicity against cancer cells. The anti-angiogenic and anti-tumor results suggests additional tumor suppressive properties. Docking analysis suggests that these compound not only has the ability to bind to EGFR and HER2 but also equally binds to VEGFR and may act as potential anti-angiogenic agents.