bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing formative and summative simulation-based assessment in undergraduate nursing students: nursing competency acquisition and clinical simulation satisfaction
Authors: Arrogante Oscar , González-Romero Gracia María , López-Torre Eva María , Carrión-García Laura , Polo Alberto 
Published: June 2021

Abstract
Background
Formative and summative evaluation are widely employed in simulated-based assessment. The aims of our study were to evaluate the acquisition of nursing competencies through clinical simulation in undergraduate nursing students and to compare their satisfaction with this methodology using these two evaluation strategies.

Methods
Two hundred eighteen undergraduate nursing students participated in a cross-sectional study, using a mixed-method. MAES© (self-learning methodology in simulated environments) sessions were developed to assess students by formative evaluation. Objective Structured Clinical Examination sessions were conducted to assess students by summative evaluation. Simulated scenarios recreated clinical cases of critical patients. Students´ performance in all simulated scenarios were assessed using checklists. A validated questionnaire was used to evaluate satisfaction with clinical simulation. Quantitative data were analysed using the IBM SPSS Statistics version 24.0 software, whereas qualitative data were analysed using the ATLAS-ti version 8.0 software.

Results
Most nursing students showed adequate clinical competence. Satisfaction with clinical simulation was higher when students were assessed using formative evaluation. The main students’ complaints with summative evaluation were related to reduced time for performing simulated scenarios and increased anxiety during their clinical performance.

Conclusion
The best solution to reduce students’ complaints with summative evaluation is to orient them to the simulated environment. It should be recommended to combine both evaluation strategies in simulated-based assessment, providing students feedback in summative evaluation, as well as evaluating their achievement of learning outcomes in formative evaluation.
Altered DNA methylation pattern reveals epigenetic regulation of Hox genes in thoracic aortic dissection and serves as a biomarker in disease diagnosis
Authors: Liu Peiru , Zhang Jing , Du Duo , Zhang Dandan , Jin Zelin , Qiu Wenqing , Zhou Xiushi , Dong Shulong , Zhou Mengyu , Zhao Heyu , Zhang Wei , Ma Jiakang , Sun Shaoyang , Fu Weiguo , Liu Yun , Wang Lixin 
Published: June 2021

Abstract
Background
Thoracic aortic dissection (TAD) is a severe disease with limited understandings in its pathogenesis. Altered DNA methylation has been revealed to be involved in many diseases etiology. Few studies have examined the role of DNA methylation in the development of TAD. This study explored alterations of the DNA methylation landscape in TAD and examined the potential role of cell-free DNA (cfDNA) methylation as a biomarker in TAD diagnosis.

Results
Ascending aortic tissues from TAD patients (Stanford type A; n = 6) and healthy controls (n = 6) were first examined via whole-genome bisulfite sequencing (WGBS). While no obvious global methylation shift was observed, numerous differentially methylated regions (DMRs) were identified, with associated genes enriched in the areas of vasculature and heart development. We further confirmed the methylation and expression changes in homeobox (Hox) clusters with 10 independent samples using bisulfite pyrosequencing and quantitative real-time PCR (qPCR). Among these, HOXA5, HOXB6 and HOXC6 were significantly down-regulated in TAD samples relative to controls. To evaluate cfDNA methylation pattern as a biomarker in TAD diagnosis, cfDNA from TAD patients (Stanford type A; n = 7) and healthy controls (n = 4) were examined by WGBS. A prediction model was built using DMRs identified previously from aortic tissues on methylation data from cfDNA. Both high sensitivity (86%) and specificity (75%) were achieved in patient classification (AUC = 0.96).

Conclusions
These findings showed an altered epigenetic regulation in TAD patients. This altered epigenetic regulation and subsequent altered expression of genes associated with vasculature and heart development, such as Hox family genes, may contribute to the loss of aortic integrity and TAD pathogenesis. Additionally, the cfDNA methylation in TAD was highly disease specific, which can be used as a non-invasive biomarker for disease prediction.
The use of Phanerochaete chrysosporium for modification of bentonite for preconcentration and determination of heavy metals
Authors: Kocaoba Sevgi , Parlak Mehtap Duman , Arisoy Munevver 
Published: June 2021

AbstractIn this study, a solid phase extraction method was successfully applied in the preconcentration and determination of trace levels of Cu(II) and Cd(II) ions and Phanerochaete chrysosporium (white rot fungus) modified bentonite was used as adsorbent. After the biosorption of Cu(II) and Cd(II) ions, metal concentrations in the samples were determined by atomic absorption spectrophotometry. pH, adsorbent amount, eluent type, sample volume, and flow rate, which are effective in the adsorption of metal ions, have been studied. 1 M HCl was used for desorption of these metal ions retained (recovery 95–100%). In addition, the effect of interfered ions has also been investigated. Sorption data were examined according to Langmuir and Freundlich adsorption equations. The results obtained show that the applied method has a high metal biosorption capacity, and Cu(II) and Cd(II) ions are successfully recovered. It was also successful in applying the proposed enrichment method to real water samples.Recovery values between 92.3% and 97.3% were obtained for the studied metal ions. According to the results, the proposed method can be successfully applied to water analysis at 95% confidence interval.
Neurogenic Thoracic Outlet Syndrome in Athletes — Nonsurgical Treatment Options
Authors: Warrick Alexandra , Davis Brian 
Published: June 2021

Abstract
Neurogenic thoracic outlet syndrome (NTOS) is an etiologically and clinically diverse disorder caused by compression of the brachial plexus traversing the thoracic outlet. Athletes who perform repetitive overhead activities are at risk of developing NTOS with sport-specific symptoms. This article reviews the controversial NTOS nomenclature, common sites of anatomic compression, and red flag symptoms that require immediate intervention. It also reviews the congenital, traumatic, and functional etiologies of NTOS, with a discussion of the differential diagnosis, diagnostic criteria, and workup for NTOS. Nonsurgical treatment is highlighted with an emphasis on thoracic outlet syndrome-specific physical therapy and updates on injection options and ultrasound guided hydrodissection. This article compares nonsurgical versus surgical functional outcome data with an emphasis on athletes with NTOS. Functional assessment tools and performance metrics for athletes are reviewed, as well as return to sport considerations.
Klebsiella pneumoniae with capsule type K64 is overrepresented among invasive disease in Vietnam
Authors: Vu Thi Ngoc Bich , Brisse Sylvain , Dao Tuyet Trinh , Vu Tien Viet Dung , Holt Kathryn E , Nguyen Vu Trung , Tran Thi Kieu Huong , Nguyen Thi Ngoc Diep , van Doorn H Rogier , Wertheim Heiman F L 
Published: June 2021

Introduction: Recent reports indicate the emergence of community-acquired pneumonia associated with K64-Klebsiella pneumoniae. Here, we identify the capsular types and sequence type of invasive and commensal K. pneumoniae isolates from Vietnam. Methods: We included 93 K. pneumoniae isolates from patients hospitalized at the National Hospital for Tropical Diseases, Hanoi between 2007 and 2011; and 110 commensal isolates from throat swabs from healthy volunteers living in rural and urban Hanoi in 2012. We determined sequence types (STs) by multi-locus sequence typing (MLST) and capsule typing for seven K types by PCR. Antibiotic susceptibility testing was performed using disk diffusion. Results: The most common detected capsule types were K1 (39/203, 19.2%, mainly ST23) and K2 (31/203, 15.3%, multiple STs: ST65, ST86, ST380). We found significantly more K2 isolates among invasive in comparison to commensal isolates (22.6% vs 9%, p = 0.01) but no significant difference was observed between invasive and commensal K1 isolates (14.5% vs 24.7%, p = 0.075). K64 with varying sequence types were predominantly seen among invasive K. pneumoniae (8 vs. 3) and were isolated from sepsis and meningitis patients. Among K64 isolates, one was carbapenem-resistant with ST799. Conclusion: Our study confirms that capsule type K64 K. pneumoniae is associated with community-acquired invasive infections in Vietnam. Research is needed to unravel the mechanisms of virulence of capsule type K64 in both community and hospital settings.
Changes in testicular tissue in obstructive azoospermia with an increase in the duration of the disease
Authors: Lesovoy V. N. , Panasovskiy N. L. , Tovazhnyanska V. D. 
Published: June 2021

To understand the infertility development it is important to study how individual components of the connective complexes of Sertoli’s cells are formed and developed in order to allow not only individual cells, but also entire syncytia of germ cells to migrate from the basal to the adluminal compartment of the spermatic epithelium, without causing loss of permeability. Testicular tissue changes in azoospermia with an increase in the duration of the disease and the prognosis of the possibility of conception are of particular interest. The aim. To reveal changes in the testicular tissue on azoospermia with an increase in the duration of the disease. Materials and methods: to achieve the aim, a pathomorphological study was carried out. The material for the study was testicular biopsies of patients aged 26-45 years with a diagnosis of obstructive azoospermia (OA). The material was divided into three groups: group 1, control: healthy fertile men; group 2 (study group): men of mature age (26–45 y. o.) with a clinical diagnosis of OA up to 5 years of duration. Group 3 (study group): men of mature age (30–45 y. o.) with a clinical diagnosis of OA up to 10 years of duration. The preparations were studied macroscopically, microscopically, morphometrically and immunohistochemically. Results and discussion. Healthy spermatogenesis was typical for all control group samples. In group 2 (disease up to 5 years from the previous conception) there were three spermatogenesis samples out of eight. There were focal processes of fibrosis and hyalinosis, with focal proliferation of interstitial tissue. In the the group of men with OA lasting up to ten years from the previous conception, the absence of healthy spermatogenesis in all cases was noted. Conclusions.1. In the group of men with OA lasting up to five years from the previous conception there were violations of spermatogenesis, a decrease in the transport of biologically active substances through the blood-testicular barrier. The latter leads to degenerative processes in the germ cells.2. In the group of men with OA lasting up to ten years from the previous conception, there was a pronounced deterioration in spermatogenesis, the transition of OA to NOA with increased duration of the pathological process. The latter significantly worsens the prognosis of the disease course and significantly reduces the possibility of conception.
Osteogenesis characteristics in the bone loss zone after the impacted mandibular third molar abnormal extraction
Authors: Nekhanevych Zhanna 
Published: June 2021

Introduction. Due to the anatomic topographic characteristics of Mandibular Third Molars’ (MTM) location, the surgical interference in the process of their extraction is often quite complicated, long-lasting as well as traumaticPurpose. Optimization of reparative osteogenesis in the area of bone defects which formed after the third molars extraction in the mandible.Material and methods. 92 patients had their impacted MTM abnormally extracted. 58 people were enrolled into the follow-up study. The inclusion criteria were female and male patients at the ages from 19 to 38; female and male patients without physical pathonomia; patients with the major bone losses, caused by the 38th and 48th teeth’s abnormal extraction; major bone loss or inter alveolar septum integration loss in the adjacent tooth area after the impacted tooth extraction; a written consent to participate in the study.Results. Clinical state comparative study, conducted in the post-surgery period, pointed that the amount and duration of inflammatory complications in group III, which appeared after the impacted MTM extraction, were significantly less than in groups I and II (р<0,05).Conclusions. The technic with the use of а-PRF, і-PRF provides inflammatory complications decrease at the post-surgery period, influences on the bone regeneration time as well as on the graft quality, but it does not prevent its dimension loss in the long term period, which leads to the receded gums and the distal root baring of the 7th tooth.
Well-being during COVID-19 pandemic: A comparison of individuals with minoritized sexual and gender identities and cis-heterosexual individuals
Authors: Buspavanich Pichit , Lech Sonia , Lermer Eva , Fischer Mirjam , Berger Maximilian , Vilsmaier Theresa , Kaltofen Till , Keckstein Simon , Mahner Sven , Behr Joachim , Thaler Christian J. , Batz Falk 
Published: June 2021

Background
Preliminary empirical data indicates a substantial impact of the COVID-19 pandemic on well-being and mental health. Individuals with minoritized sexual and gender identities are at a higher risk of experiencing such negative changes in their well-being. The objective of this study was to compare levels of well-being among cis-heterosexual individuals and individuals with minoritized sexual and gender identities during the COVID-19 pandemic.

Methods
Using data obtained in a cross-sectional online survey between April 20 to July 20, 2020 (N = 2332), we compared levels of well-being (WHO-5) across subgroups (cis-individuals with minoritized sexual identities, individuals with minoritized gender identities and cis-heterosexual individuals) applying univariate (two-sample t-test) and multivariate analysis (multivariate linear regression).

Results
Results indicate overall lower levels of well-being as well as lower levels of well-being in minoritized sexual or gender identities compared to cis-heterosexual individuals. Further, multivariate analyses revealed that living in urban communities as well as being in a relationship were positively associated with higher levels of well-being. Furthermore, a moderation analysis showed that being in a relationship reduces the difference between groups in terms of well-being.

Conclusion
Access to mental healthcare for individuals with minoritized sexual and gender identities as well as access to gender-affirming resources should be strengthened during COVID-19 pandemic. Healthcare services with low barriers of access such as telehealth and online peer support groups should be made available, especially for vulnerable groups.
Logic model evaluation and the analysis of job motivation for pre-paring the performance indicators of government institution: case of Klungkung, Bali
Authors: Prayudi Made Aristia , Dewi Gusti Ayu Ketut Rencana Sari , Masdiantini Putu Riesty 
Published: June 2021

When compared to other districts in Bali Province, Klungkung has the lowest performance accountability score. The current study aims to evaluate the technical and psychological aspects of performance indicators development process of the local government. The technical aspect evaluation was done by implementing logic model analysis procedures and adopting a four-quadrant analysis approach. The Â psychological aspect analysis was conducted by examining the motivational factors taken from the perspective of Institutional Theory for determining individual behavior in developing performance indicators in governmental organizations. The results show that there is a discrepancy in the number of performance indicators presented in the planning and performance reporting documents, as well as an absence of logical relationships among them. Psychologically, the quality of Klungkungâ€™s performance indicators development is determined by the perception of the performance indicators matrix difficulty, the perceived usefulness of technical training, the level of top management commitment, the assertiveness enforcement of the regulations, and the existence of social pressure and pressure on professionalism. It can be implied that technical policies need to be formulated by local government organizations. Â
Chronic gastritis and precancerous diseases of the stomach: Is there a chance of a correct diagnosis?
Authors: Tryapitsyn Aleksandr V. , Malkov Vladimir A. , Gasanov Emil M. , Belyakov Ilya 
Published: June 2021

AIM: The purpose of the study is to investigate the occurrence of the main forms of chronic gastritis, metaplastic and dysplastic changes in the gastric mucosa, the degree of their severity, and to assess their potential risk for the development of gastric cancer.
MATERIALS AND METHODS: The study involved 2982 patients who underwent esophagogastroduodenoscopy with a standard biopsy of the gastric mucosa for morphological assessment and bacterioscopy. If autoimmune gastritis was suspected, an additional serological diagnosis was performed. When detecting intestinal metaplasia of the gastric mucosa as well as neoplastic changes according to the histological report, the description of this report was analyzed in order to identify possible equivalents in the macroscopic description of the mucous membrane.
RESULTS: Out of 2982 histological studies of gastric mucosa biopsies, 1273 cases (42.7%) were found to contain H. pylori contamination. In 726 cases (24.3%), intestinal metaplasia. 66 biopsies (2.21%) showed the presence of low-grade intraepithelial neoplasia of the mucosa, 2 biopsies showed indeterminate neoplasia and 4 biopsies showed high-grade neoplasia. In 3 out of the total number of the samples, intravascular gastric adenocarcinoma was detected. In 168 cases (5.6%), gastritis was detected with predominant inflammation of the fundal region characteristic of autoimmune gastritis. In 286 biopsies (10.6%), inflammatory and/or atrophic changes and/or metaplastic changes were preserved, which, as a rule, did not have high activity and pronounced inflammation. In the remaining 1279 cases (42.9%), there was no significant inflammation or atrophic changes. The analysis of endoscopic findings showed that the detectability of intestinal metaplasia of the gastric mucosa without a biopsy study was 13.3%.
DISCUSSION OF THE RESULTS: According to the results of the conducted research and analysis, it can be stated that at present, the correct diagnosis of chronic gastritis with the establishment of the etiological factor, prognosis and risks of stomach cancer development is practically not feasible within the modern health care system. This not only deprives a doctor of the opportunity to make a correct diagnosis and prescribe adequate treatment to a patient, but also makes almost all cascades of carcinogenesis, including early cancer, invisible.
Efek Ekstrak Kulit Mangga Arumanis terhadap Penurunan Edema Kaki Mencit Putih Jantan yang Diinduksi Karagenin
Authors: Anggraini Ongky Dyah , Komariah Cicih , Prasetyo Aris 
Published: June 2021

Mango is a plant contains many active compounds with health benefits. Total phenolic content of mango peel is higher than mango flesh, with its major component are mangiferin and quercetin. Quercetin has anti-inflammatory effects through the inhibition of inflammatory mediators are serotonin, bradykinin, histamine and prostaglandin, possibly could reduce oedema as a sign of inflammation. This study used carrageenin to induce inflammation by making paw oedema in mice. The aim of this research was to know the effect of arumanis mango peel extract to reduce paw oedema in white male mice. The was quasi experimental study with 7 study groups. Spearman analyses showed a correlation with significance of (p= 0.003) that mean it has a significant correlation (p <0.01) at the 330th min. Spearman correlation coefficients was 0,632, indicated that the dose of extract and paw oedema have strong correlation. It can be concluded that mango peel extract has effect for reducing paw oedema in white male mice, with the smallest dose was 1,002mg / gBW.

Keywords: mango, quercetin, paw oedema
Eugenia Torijano Pérez. Ser (de nuevo) doctor por Salamanca. Las tesis doctorales de la Facultad de Derecho en el Sexenio Revolucionario (1868-1874)
Authors: Martínez Neira Manuel 
Published: June 2021

Este artículo reseña: Eugenia Torijano Pérez. Ser (de nuevo) doctor por Salamanca. Las tesis doctorales de la Facultad de Derecho en el Sexenio Revolucionario (1868-1874). Madrid: Dykinson, 2021.
KINERJA ORGANISASI PENGELOLA TINGKAT MASYARAKAT DALAM PEMANFAATAN DAN PEMELIHARAAN HASIL PROGRAM SANIMAS DI KELURAHAN KAPALO KOTO KOTA PADANG
Authors: Hafizhah Hafizhah 
Published: June 2021

This research is motivated by environmental pollution because many people do not yet have access to proper domestic wastewater sanitation. Kapalo Koto Village is one of the priority villages in handling sanitation in Padang City. The results showed that of the four variables proposed by Wibowo, it can be concluded that the Performance of Community Level Management Organizations in the Utilization and Maintenance of the Results of the SANIMAS Program in the Kapalo Koto Village Padang City has not yet reached its maximized. Utilization and maintenance activities of the SANIMAS Program result in the Kapalo Koto Village experienced several obstacles. Caused by several indicators that have not been maximized, such as the capability of low Community Level Management Organizations, sources of funding from beneficiary community contributions for program maintenance and development are not collected. The implementation of utilization and maintenance activities is still not routinely carried out. Continued monitoring is not conducted regularly and evaluation activities are not carried out annually. However, if seen from the benefits generated by the SANIMAS Program it has an impact on reducing pollution to the residential environment, thereby causing an increase in the level of public health. Keywords: Performance, Management Organizations, SANIMAS Program
IMPLEMENTASI KEBIJAKAN E-VOTING DALAM PEMILIHAN KEPALA DESA DI KABUPATEN MEMPAWAH PROVINSI KALIMANTAN BARAT
Authors: Maryuni Sri , Sitorus R.L 
Published: June 2021

This research intended to explain the implementation of e-voting policy on the head of the village election at Mempawah Region Kalimantan Barat. The election was done for twice occasions, at 2017 and 2018. Purpose of the research was to describe and analyze the implementation process of e-voting policy on the head of the village election at Mempawah Region Kalimantan Barat. The research method in this paper was using qualitative methods with descriptive technique. In order to gain information on the implementation process of e-voting policy on the head of the village at Mempawah Region, Kalimantan Barat. Charles O. Jones (1996: 296) theory stated that the implementation process of e-voting policy was based on three pillars, which are the organization, interpretation, and application. We found that there were some obstacles in implementing e-voting policy, such as the lack of electronic facilities quantity and quality that supported the policy, there were also a lot of people which has not been registered in the e-voting application, and some negatives perception of the e-voting process. Researchers have several recommendations to overcome the problems. First, the government should do socialization on the e-voting election. Second, an improvement in the e-voting system especially on the issue of the person with disabilities. Third, evaluate the regulation. Lastly, increase the coordination among stakeholders within bureaucracy and village staff in order to have a better database of the elector.