bluuebunny/crossref_metadata_2025_split huggingface dataset:
An innovative strategy to rapidly inactivate 8.2-log Enterococcus faecalis in fresh pineapple juice using cold atmospheric plasma
Authors: Sohbatzadeh Farshad , Yazdanshenas Homayoon , Soltani Amir-Hossain , Shabannejad Amir 
Published: August 2021

AbstractEnterococcus faecalis is a life-threatening bacterium that resists high levels of antibiotics or chemical preservatives. In this study, we aimed to investigate the inactivation of E. faecalis in fresh pineapple juice (FPJ) with two different cold atmospheric plasmas (CAP) reinforced by H2O2/H2O cold vapor: a plasma jet and a surface dielectric barrier discharge (SDBD). CAP treatments for 300 s with plasma jet and 420 s with SDBD caused an 8.2 log reduction of E. faecalis. The concentration of reactive oxygen and nitrogen species induced in FPJ by plasmas was also evaluated. In terms of quality attributes of FPJ, no noticeable color changes (ΔE) were observed. Furthermore, a trifle of loss of organic content such as sugars and organic acids was observed after treatments. These results suggest that our rapid CAP strategy effectively inactivated E. faecalis in FPJ with no change of color and negligible effects on other physicochemical properties.
A systematic review and meta-analysis of the association between vitamin D and ovarian reserve
Authors: Karimi Elham , Arab Arman , Rafiee Masoumeh , Amani Reza 
Published: August 2021

AbstractIt is hypothesized that vitamin D deficiency could be related to ovarian reserve. This systematic review and meta-analysis was undertaken to analyze the possible association between vitamin D and ovarian reserve among adolescent and adult women. All eligible studies identified through the ISI Web of Science, PubMed, and Scopus were included up to May 2021. A random-effects meta-analysis model was implemented and a weighted mean difference (WMD) and 95% confidence interval (CI) were calculated. A total of 38 papers covering 8608 individuals were enrolled in this systematic review and meta-analysis. Antral follicle count (AFC) was significantly lower among Asians (WMD − 0.65; 95% CI − 1.28 to − 0.01; P = 0.04; I2 = 0.0%) and luteinizing hormone (LH) levels were higher in non-Asians (WMD 2.16 IU/L; 95% CI 0.20 to 4.12; P = 0.031; I2 = 9.3%) with vitamin D insufficiency/deficiency. Also, there was a negative correlation between vitamin D and LH/FSH ratio in women with normal body mass index (BMI) (Fisher’s Z: − 0.18; 95% CI − 0.37 to − 0.008; P = 0.041; I2 = 51.5%). Although there were no significant associations between serum vitamin D levels and any of the intended ovarian reserve markers, subgroup analyses have found significant findings regarding AFC, LH, and LH/FSH ratio. In order to understand the underlying mechanisms of vitamin D in female reproduction, further attempts are needed.
Towards precision cardiometabolic prevention: results from a machine learning, semi-supervised clustering approach in the nationwide population-based ORISCAV-LUX 2 study
Authors: Fagherazzi Guy , Zhang Lu , Aguayo Gloria , Pastore Jessica , Goetzinger Catherine , Fischer Aurélie , Malisoux Laurent , Samouda Hanen , Bohn Torsten , Ruiz-Castell Maria , Huiart Laetitia 
Published: August 2021

AbstractGiven the rapid increase in the incidence of cardiometabolic conditions, there is an urgent need for better approaches to prevent as many cases as possible and move from a one-size-fits-all approach to a precision cardiometabolic prevention strategy in the general population. We used data from ORISCAV-LUX 2, a nationwide, cross-sectional, population-based study. On the 1356 participants, we used a machine learning semi-supervised cluster method guided by body mass index (BMI) and glycated hemoglobin (HbA1c), and a set of 29 cardiometabolic variables, to identify subgroups of interest for cardiometabolic health. Cluster stability was assessed with the Jaccard similarity index. We have observed 4 clusters with a very high stability (ranging between 92 and 100%). Based on distinctive features that deviate from the overall population distribution, we have labeled Cluster 1 (N = 729, 53.76%) as “Healthy”, Cluster 2 (N = 508, 37.46%) as “Family history—Overweight—High Cholesterol “, Cluster 3 (N = 91, 6.71%) as “Severe Obesity—Prediabetes—Inflammation” and Cluster 4 (N = 28, 2.06%) as “Diabetes—Hypertension—Poor CV Health”. Our work provides an in-depth characterization and thus, a better understanding of cardiometabolic health in the general population. Our data suggest that such a clustering approach could now be used to define more targeted and tailored strategies for the prevention of cardiometabolic diseases at a population level. This study provides a first step towards precision cardiometabolic prevention and should be externally validated in other contexts.
Smooth borders between inner nuclear layer and outer plexiform layer predict fewer macular edema recurrences in branch retinal vein occlusion
Authors: Sasajima Hirofumi , Tsuboi Kotaro , Kiyosawa Rokuki , Fukutomi Akira , Murotani Kenta , Kamei Motohiro 
Published: August 2021

AbstractWe hypothesized the smoothness of the border between the inner nuclear layer (INL) and outer plexiform layer (OPL) associates with the frequency of macular edema (ME) recurrences secondary to branch retinal vein occlusion (BRVO). Thirty-seven consecutive eyes with BRVO treated with anti-vascular endothelial growth factor (VEGF) injections at 1-year follow-up were included. We manually traced the border between the INL and OPL within the 1.5-mm vertical line from the fovea on optical coherence tomography (OCT) images at the initial visit. The jagged ratio (JR), the border length divided by the spline curve length, was calculated. We performed univariate and multivariate regression analyses, including JR, patient characteristics, number of cystoid spaces in the INL, INL area, and outer retina area. Multivariate regression analysis showed JR significantly correlates with the total number of anti-VEGF injections (P < 0.0001). Moreover, the mean JR was significantly lower in the nine eyes receiving two or fewer injections than in the 28 eyes receiving three or more injections (1.02 ± 0.01 vs. 1.13 ± 0.06,P < 0.0001). A smooth border between the INL and the OPL on OCT images at the initial visit may be a biomarker for fewer ME recurrences in eyes with BRVO.
Rare and common variant discovery by whole-genome sequencing of 101 Thoroughbred racehorses
Authors: Tozaki Teruaki , Ohnuma Aoi , Kikuchi Mio , Ishige Taichiro , Kakoi Hironaga , Hirota Kei-ichi , Kusano Kanichi , Nagata Shun-ichi 
Published: August 2021

AbstractThe Thoroughbred breed was formed by crossing Oriental horse breeds and British native horses and is currently used in horseracing worldwide. In this study, we constructed a single-nucleotide variant (SNV) database using data from 101 Thoroughbred racehorses. Whole genome sequencing (WGS) revealed 11,570,312 and 602,756 SNVs in autosomal (1–31) and X chromosomes, respectively, yielding a total of 12,173,068 SNVs. About 6.9% of identified SNVs were rare variants observed only in one allele in 101 horses. The number of SNVs detected in individual horses ranged from 4.8 to 5.3 million. Individual horses had a maximum of 25,554 rare variants; several of these were functional variants, such as non-synonymous substitutions, start-gained, start-lost, stop-gained, and stop-lost variants. Therefore, these rare variants may affect differences in traits and phenotypes among individuals. When observing the distribution of rare variants among horses, one breeding stallion had a smaller number of rare variants compared to other horses, suggesting that the frequency of rare variants in the Japanese Thoroughbred population increases through breeding. In addition, our variant database may provide useful basic information for industrial applications, such as the detection of genetically modified racehorses in gene-doping control and pedigree-registration of racehorses using SNVs as markers.
Poleward eddy-induced warm water transport across a shelf break off Totten Ice Shelf, East Antarctica
Authors: Hirano Daisuke , Mizobata Kohei , Sasaki Hiroko , Murase Hiroto , Tamura Takeshi , Aoki Shigeru 
Published: August 2021

AbstractIce mass loss in the Wilkes Land sector of East Antarctica and the Amundsen and Bellingshausen Sea sectors of West Antarctica has contributed to a rise in sea levels over several decades. The massive continental ice behind the Totten Ice Shelf, equivalent to a few meters of sea-level rise, is grounded well below sea level and therefore, potentially vulnerable to oceanic heat. Here, we present analyses of comprehensive hydrographic observations at the continental slope and shelf break regions off Totten Ice Shelf. We provide robust evidence that the relatively warm Circumpolar Deep Water that originates at intermediate depths in the Antarctic Circumpolar Current is transported efficiently towards the shelf break by multiple cyclonic eddies. We propose that these semi-permanent cyclonic circulations play a critical role in transporting the available ocean heat towards Totten Ice Shelf, and melting it from underneath, thus eventually influencing the global climate.
One-step methylation of aromatic phosphorus heterocycles: synthesis and crystallographic characterization of a 1-methyl-phosphininium salt
Authors: Fischer Lukas , Wossidlo Friedrich , Frost Daniel , Coles Nathan T. , Steinhauer Simon , Riedel Sebastian , Müller Christian 
Published: August 2021

By using the dimethyl chloronium salt [(CH3)2Cl]+ [Al(OTeF5)4]− in combination with the weakly coordinating pentafluoro-orthotelluratoaluminate anion it is possible to quaternize the phosphorus atom of a series of λ3,σ2-phosphinines in one step.
Octahedral distortion driven by CsPbI3 nanocrystal reaction temperature – the effects on phase stability and beyond
Authors: Matuhina Anastasia , Grandhi G. Krishnamurthy , Liu Maning , Smått Jan-Henrik , Viswanath N. S. M. , Ali-Löytty Harri , Lahtonen Kimmo , Vivo Paola 
Published: August 2021

Cesium lead iodide (CsPbI3) perovskite nanocrystals (NCs) synthesized at 150 °C show a significantly enhanced phase stability from the red-emitting (black) to non-emitting (yellow) phase.
Covariance regulation based invariant Kalman filtering for attitude estimation on matrix Lie groups
Authors: Wang Jiaolong , Li Minzhe 
Published: August 2021

AbstractFor matrix Lie groups attitude estimation problems with the trouble of unknown/inaccurate process noise covariance, by elaborating the proportion based covariance regulation scheme, this work proposes a novel version of adaptive invariant Kalman filter (AIKF). Invariant Kalman filter (IKF) takes into account the group geometry and can give better results than Euclidean Kalman filters, but it still heavily depends on the accuracy of noise statistics parameters. To ease this constraint, IKF's covariance propagation step is removed and a proportional regulation scheme is elaborated for the proposed AIKF: the feedback of posterior sequence is introduced to construct a closed‐loop structure of covariance propagation, and then a proportional regulator is employed to amplify the feedback and accelerate the convergence of covariance calibration. As the main benefit, implementation of new AIKF does not require the accurate knowledge of noise statistics, which is also the main advantage over IKF. The mathematical derivation of proposed covariance regulation scheme is presented and the numerical simulations of the Lie groups attitude estimation problem are used to certify the filtering performance of the new approach.
Revealing the structure of the lensed quasar Q 0957+561
Authors: Fian C. , Mediavilla E. , Jiménez-Vicente J. , Motta V. , Muñoz J. A. , Chelouche D. , Goméz-Alvarez P. , Rojas K. , Hanslmeier A. 
Published: August 2021

Aims. We aim to use signatures of microlensing induced by stars in the foreground lens galaxy to infer the size of the accretion disk in the gravitationally lensed quasar Q 0957+561. The long-term photometric monitoring of this system (which so far has provided the longest available light curves of a gravitational lens system) permits us to evaluate the impact of uncertainties on our recently developed method (controlled by the distance between the modeled and the experimental magnitude difference histograms between two lensed images), and thus to test the robustness of microlensing-based disk-size estimates.
Methods. We analyzed the well-sampled 21-year GLENDAMA optical light curves of the double-lensed quasar and studied the intrinsic and extrinsic continuum variations. Using accurate measurements for the time delay between the images A and B, we modeled and removed the intrinsic quasar variability, and from the statistics of microlensing magnifications we used a Bayesian method to derive the size of the region emitting the continuum at λrest = 2558 Å.
Results. Analysis of the Q 0957+561 R-band light curves show a slow but systematic increase in the brightness of the B relative to the A component during the past ten years. The relatively low strength of the magnitude differences between the images indicates that the quasar has an unusually big optical accretion disk of half-light radius: R1/2 = 17.6±6.1 √(M/0.3 M⊙) lt-days.
Im Sommer: Abschalten, Kraft tanken, Neues lernen
Authors: Börner Doris , Zohmann Andreas 
Published: August 2021

Liebe Leserin, lieber Leser,der Sommer ist da. Sommerzeit ist ja Urlaubszeit. Und für viele gibt es nun
auch die ersten „richtigen“ Urlaube seit vielen Monaten. Dank der
sinkenden Corona-Inzidenzwerte sowie dem stetigen Impffortschritt ist es nun auch
wieder einigermaßen möglich, zu verreisen.
SGLT-2 Inhibition – neues Therapiekonzept bei Herzinsuffizienz
Authors: Schütt Katharina , Berger Martin , Marx Nikolaus 
Published: August 2021

ZusammenfassungSGLT2-Inhibitoren stellen eine neue Substanzklasse in der Therapie der Herzinsuffizienz dar, die initial zur Therapie des Typ-2-Diabetes entwickelt wurde. In großen kardiovaskulären Endpunktstudien konnte zunächst bei Patienten mit Typ-2-Diabetes gezeigt werden, dass SGLT2-Inhibitoren Herzinsuffizienz-assoziierte Endpunkte reduzieren. Daher wurden im Verlauf gezielt Studien bei Patienten mit Herzinsuffizienz mit eingeschränkter LV-Funktion (HFrEF) durchgeführt. In den bislang veröffentlichten Studien konnte gezeigt werden, dass Dapagliflozin oder Empagliflozin zu einer signifikanten Reduktion des Endpunktes Hospitalisierung für Herzinsuffizienz oder kardiovaskulären Tod führt. Damit stellt diese Substanzklasse eine neue Therapieoption für Patienten mit HFrEF dar. Der vorliegende Artikel gibt einen Überblick über die aktuelle Datenlage und stellt SGLT2-Inhibitoren in den Kontext der bisherigen Behandlung bei Herzinsuffizienz.
The Standardized Wood Extract of Albizia myriophylla: Its Potential as an Active Ingredient in an Anti-inflammatory Herbal Gel Formulation
Authors: Bakasatae Nazneen , Sangkaew Warissara , Kunworarath Nongluk , Ontong Julalak Chorachoo , Phoopha Sathianpong , Takahashi Yupanqui Chutha , Voravuthikunchai Supayang Piyawan , Joycharat Nantiya 
Published: August 2021

Abstract
Albizia myriophylla has been used in Thai folk medicine for treating inflammation-related diseases. The wood of this medicinal plant is traditionally used as a single herbal drug in the form of an aqueous decoction and as a component in several Thai herbal formulations for the remedy of fever, sore throat, and aphthous ulcers. This study aimed to evaluate in vivo the anti-inflammatory potential and possible mechanism of action of the standardized wood extract of A. myriophylla as well as to investigate the anti-inflammatory activity and physicochemical properties of the developed herbal gel formulation containing standardized wood extract of A. myriophylla. Results of quantitative HPLC analysis demonstrated that the standardized wood extract of A. myriophylla contained 22.95 mg/g of 8-methoxy-7,3′,4′-trihydroxyflavone, a bioactive marker compound of A. myriophylla. The standardized wood extract of A. myriophylla (1% w/v)
exhibited remarkable inhibition (54.4 – 80.3%) in the croton oil model of topical inflammation at all assessment times, comparable to standard indomethacin (55.3 – 63.6%). Real-time quantitative reverse transcription-polymerase chain reaction was performed to clarify the anti-inflammatory mechanism of standardized wood extract of A. myriophylla, and the result showed that this standardized extract decreased lipopolysaccharide-induced nitric oxide synthase mRNA levels in a dose-dependent manner. The developed herbal gel containing standardized wood extract of A. myriophylla (1% w/w) had good physicochemical characteristics and exhibited potent inhibition (51.4 – 77.8%) of inflammation in a rat ear edema model at all assessment times, comparable to indomethacin gel (33.3 – 40.5%). The notable anti-inflammatory activity of standardized wood extract of A. myriophylla and its developed herbal gel formulation indicates their potential application as
natural anti-inflammatory agents.
Competitive CatSper Activators of Progesterone from Rhynchosia volubilis
Authors: Xiang Jin , Kang Hang , Li Hong-Gang , Shi Yu-Long , Zhang Ya-Li , Ruan Chang-Lei , Liu Lin-Hui , Gao Han-Qi , Luo Tao , Hu Gao-Sheng , Zhu Wei-Liang , Jia Jing-Ming , Chen Jia-Chun , Fang Jin-Bo 
Published: August 2021

AbstractThe root Rhynchosia volubilis was widely used for contraception in folk medicine, although its molecular mechanism on antifertility has not yet been revealed. In human sperm, it was reported that the cation channel of sperm, an indispensable cation channel for the fertilization process, could be regulated by various steroid-like compounds in plants. Interestingly, these nonphysiological ligands would also disturb the activation of the cation channel of sperm induced by progesterone. Therefore, this study aimed to explore whether the compounds in R. volubilis affect the physiological regulation of the cation channel of sperm. The bioguided isolation of the whole herb of R. volubilis has resulted in the novel discovery of five new prenylated isoflavonoids, rhynchones A – E (1 – 5), a new natural product, 5′-O-methylphaseolinisoflavan (6) (1H and 13C NMR data, Supporting Information), together with twelve known compounds (7 – 18). Their structures were established by extensive spectroscopic analyses and drawing a comparison with literature data, while their absolute configurations were determined by electronic circular dichroism calculations. The experiments of intracellular Ca2+ signals and patch clamping recordings showed that rhynchone A (1) significantly reduced cation channel of sperm activation by competing with progesterone. In conclusion, our findings indicat that rhynchone A might act as a contraceptive compound by impairing the activation of the cation channel of sperm and thus prevent fertilization.
Can Non-Invasive Capnography and Integrated Pulmonary Index Contribute to Patient Monitoring in the Pediatric Emergency Department?
Authors: Gurlu Ramazan , Tolu Kendir Ozlem , Baspinar Omer , Erkek Nilgun 
Published: August 2021

Abstract
Objectives Noninvasive capnography (NICG) devices can measure oxygen saturation, end-tidal carbon dioxide (EtCO2), respiratory rate, heart rate values and integrated pulmonary index (IPI). This study aimed to evaluate patients who were monitored using NICG for various indications in a pediatric emergency department and to determine its contribution to patient management in the pediatric emergency department (PED).
Methods In this study, children aged <18 years who had been monitored with a NICG at the PED in our university between August 2018-May 2019 were evaluated. Of them 48 patients' file records and monitored capnography parameters such as heart rate, respiratory rate, blood pressure, capillary refill time, Glasgow Coma Score, SpO2, EtCO2, IPI recorded in the forms were reviewed.
Results Patients most often presented to the emergency room due to seizures (35.4%), change in consciousness (22.9%), other neurological reasons (18.8%) with %50 were female. Seizure treatment(16.7%), circulatory–respiratory support(16.7%), and antiedema treatments(6.3%) were required for 39.5% patients as life-saving interventions, and 72.9% patients were hospitalized. Patients with low IPI(<8) values at the beginning and decreasing IPI (<8) measurements within monitoring period needed more life-saving treatments(p=0.005 and p=0.001, respectively). Low IPI values of the patients during monitoring showed a significant difference in the decision to be hospitalized(p=0.048).
Conclusions The results of the present study indicate that monitoring with NICG in the pediatric emergency room can be an important early indicator in establishing clinical prediction. The study particularly points out that the IPI value can be a guide in decisions regarding life-saving treatment and hospitalization. Among the capnographic data of these patients who had a change in consciousness IPI values those measured at the beginning and within the monitorizarion period showed a significant correlation with low GCS (<8) (r=0.478, p=0.001 and r=0.456, p=0.02, respectively). Prospective comprehensive large scale studies are needed to examine the use of NICG and IPI in routine PED practice for various indications.
Bulbine natalensis (currently Bulbine latifolia) and select bulbine knipholones modulate the activity of AhR, CYP1A2, CYP2B6, and P-gp
Authors: Husain Islam , Dale Olivia R. , Manda Vamshi , Ali Zulfiqar , Gurley Bill J. , Chittiboyina Amar G. , Khan Ikhlas A. , Khan Shabana I. 
Published: August 2021

Abstract
Bulbine natalensis, an emerging medicinal herb on the global market with androgenic properties, is often formulated in dietary supplements that promote perceived sexual enhancement. However, to date, comprehensive safety studies of B. natalensis are lacking, particularly those related to its herb-drug interaction potential. The purpose of this study was to assess the inductive and inhibitory effects of extracts and pure compounds of B. natalensis on human cytochrome P-450 isozymes in vitro. Our findings demonstrated that both water and methanolic extracts of B. natalensis as well as knipholone, bulbine-knipholone, and 6′-O-methylknipholone dose-dependently increased mRNA expression encoded by CYP2B6, CYP1A2, and ABCB1 genes. Functional analyses showed that water (60 to 2.20 µg/mL) and methanolic (30 to 3.75 µg/mL) extracts and knipholones (10 to 0.33 µM) increased CYP2B6 and CYP1A2 activity in a dose-dependent
manner. Additionally, water extract (60 µg/mL), methanolic extract (30 µg/mL), and knipholone (10 µM) caused activation of the aryl hydrocarbon receptor up to 11.1 ± 0.7, 8.9 ± 0.6, and 7.1 ± 2.0-fold, respectively. Furthermore, inhibition studies revealed that methanolic extract attenuated the activity of metabolically active CYP1A2 (IC50, 22.6 ± 0.4 µg/mL) and CYP2B6 (IC50, 34.2 ± 6.6 µg/mL) proteins, whereas water extracts had no inhibitory effect on either isoform. These findings suggest that chronic consumption of B. natalensis may affect normal homeostasis of select CYPs with subsequent risks for HDIs when concomitantly ingested with conventional medications that are substrates of CYP2B6 and CYP1A2. However, more in-depth translational studies are required to validate our current findings and their clinical relevance.
One-Pot Synthesis of Cyclic Isothioureas
Authors: Sun Zhihua , Wang Jun 
Published: August 2021

AbstractThe one-pot synthesis of cyclic isothioureas is reported. This method provides a straightforward and efficient approach to the synthesis of a broad range of cyclic isothioureas with yields of up to 90% and in quantities of up to 5 g. It is of great value for the preparation of classic organocatalysts, such as benzotetramisole and homobenzotetramisole.