bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved Simulation Efficiency for Optimising Inflow Control Device Completions Using Suitably Upscaled Models and Parallel Global Search Optimisation Techniques
Authors: Awid Abdurrezagh , Guo Chengjun , Geiger Sebastian 
Published: December 2021

Abstract
Inflow Control Device (ICD) completions can improve well performance by adjusting the inflow profile along the well and reducing the influx of unwanted fluids. The ultimate aim of using ICD completions is to provide maximum oil recovery and/or Net Present Value (NPV) over the life of the field. Proactive ICD optimisation studies use complex reservoir models and high-dimensional nonlinear objective functions to find the optimum ICD configurations over the life of the field. These complex models are generated from fine scale detailed geological models to accurately capture fluid flow behaviour in the reservoir. Although these high-resolution geological models can provide better performance predictions, their simulation runtimes can be computationally expensive and time consuming for performing proactive ICD optimisation studies that often require thousands of simulation runs.
We propose a new workflow where we use upscaled and locally refined models coupled with parallelised global search optimisation techniques to improve the simulation efficiency when performing ICD optimisation and decision-making studies. Our approach preserves the flow behaviour in the reservoir and maintains the interaction between the reservoir and the well in the near wellbore region. Moreover, when coupled with parallel optimisation techniques, the simulation time is significantly reduced.
We present an in-house code that couples global search optimisation algorithms (Genetic Algorithm and Surrogate Algorithm) with a commercial reservoir simulator to drive the ICD configurations. We evaluate the NPV as the objective function to determine the optimum ICD configurations. We apply and benchmark our approach to two different reservoir models to compare and analyse its efficiency and the optimisation results.
Our analysis shows that our proposed approach reduces the run time by more than 80% when using the upscaled models and the parallel optimisation techniques. These results were based on a standard dual-core parallel desktop configuration. Additional results also showed further reduction in run time is possible when employing more processors. Additionally, when testing different ICD completion strategies (ICDs in producers only, ICDs in injectors only, and ICDs in both producers and injectors), the NPV can be increased by 9.6% for the optimised ICD completions.
The novelty of our work is rooted in the much-improved simulation efficiency and better performance predictions that supports ICD optimisation and decision-making studies during field development planning to maximize profit and minimize risk over the life of the field.
Depositional Processes of the Cenomanian-Turonian Reworked Carbonates in the Eastern Abu Dhabi, UAE
Authors: Shimomura Takahiro , Yamanaka Motoyoshi 
Published: December 2021

Abstract
There are a limited number of studies and exploration cases for a "reworked carbonate" in Abu Dhabi, although these sediments are composed from some large oil and gas fields around the world (e.g. Poza Rica oil field in Mexico and Ruby gas field in Indonesia). In this study, we focused on Cenomanian-Turonian carbonates and considered the depositional processes of a "reworked carbonate" in the eastern part of Abu Dhabi.
To understand the stacking pattern and/or depositional process of the Cenomanian-Turonian carbonate, we conducted a well-well correlation for total 16 wells, based on the core observations, wireline logs correlation (GR, Neutron, Density, Resistivity and Sonic), carbon and oxygen isotope analysis and trace elements analysis. Sampling was conducted for 8 wells and samples were taken approximately every 5 ft. In addition, to predict the spatiotemporal expansion of the reworked deposit, a 3D seismic interpretation was conducted.
The result of the well-well correlation reveals that the depositional process and the stacking pattern of the Cenomanian-Turonian shoals around eastern Abu Dhabi are well consistent with the depositional model that proposed by Razin et al., 2010, and the reworked deposits are developed around the distal environment. 3D seismic interpretation represents that these reworked sediments were input from the north-west side and spread to the south-east like as a submarine-fan. Considering the core observation result, cohesive debris flow deposits are dominated at the depositional up-dip side and dilute flow deposits are dominated in the depositional down-dip side. In addition, an obvious erosional surface can be recognized in seismic sections and it truncates the top shoal sediments. The result of both, a combination of localized up-rift and global eustatic sea level fall in the early-middle Turonian triggered the regional erosion which is recognized as the middle Turonian unconformity. The result of this study suggests that the shoal sediments were eroded and reworked to a more distal environment at the early-middle Turonian.
Boronic Ester-Polyurethane as a Self-Healing Coating Material for Offshore Top Side Structures Application
Authors: Samsudin Mohd Shamsul Farid , Aba Norfarah Diana , Zakaria Muzdalifah , Nor Azmi Mohammed , Varley Russell , Zhang Jane 
Published: December 2021

Abstract
Polymer coatings, especially epoxy and polyurethane paint systems, have been widely used to prevent corrosion of metallic components and structures. However, due to environmental and mechanical effects, the barrier efficiency of the coatings may be substantially compromised during transportation and service, as demonstrated by localized scratches, delamination, or stress-related microcracks. Application of a self-healing coating that can restore damages and recover its performance with minimal external intervention could prevent corrosion at the damaged coating. In this present work, the healing efficiency and long-term durability of Boronic Ester (BE) blended with Polyurethane (PU) as a self-healing system for top side coating of offshore platform structures was investigated. The BE was mixed at a ratio of 50:50 with PU resin and applied as a top layer on a PU coated steel plate with a thickness of approximately 300-350 μm. The healing efficiency, mechanical performance, and durability under simulated environmental conditions such as salt spray and UV were investigated according to the related ASTM standards. As a first step, the electrical impedance spectroscopy (EIS) and 3D profilemeter microscope were used to assess the healing ability of the scratched coating at room temperature and humidity level of 85 %. The mechanical performance of the self-healing coating layer was evaluated using a pull off adhesion test to investigate the compatibility of the self-healing system with the existing commercial PU topcoat system, while a long term 3000 hours salt spray and 4200 hours cyclic UV test were performed to evaluate the self-healing coating's durability in harsh conditions. Preliminary assessment using EIS and 3D profilemeter microscopes on the scratched PU/BE self-healing coating revealed significant healing efficiency of more than 80% for healing condition at ambient temperature and humidity level of 85%. The self-healing coating layer also demonstrated excellent adhesion efficiency, with adhesion greater than 300 psi suggesting good compatibility of the BE-PU layer with commercial PU coating. The salt spray and cyclic UV tests that were performed to determine the durability of the self-healing coating revealed that the 50BE/50PU layer remained intact and exhibited good healing performance with more than 80% efficiency even after exposure to harsh conditions. The findings from the study demonstrated that the BE/PU material has the potential to be used as a self-healing system for topside coating of offshore platforms structures, thereby lowering maintenance costs.
EOR Returned Polymer Removal from Produced Water by Chemical Coagulation – A Successful Pilot Testing
Authors: Zagitov Robert , Subramanian Jaisankar , Gopisetty Srinivasa Rao , Kumar Avinash , Mathur Vinay , Venkat Panneer Selvam , Mehta Dharmesh 
Published: December 2021

Abstract
Severe fouling of crude oil and produced water treatment equipment of Mangala Processing Terminal (MPT) with elastic deposits has been observed after EOR polymer breaking through to the producing wells. Fouling by polymer containing solids caused the system bottlenecking impacting on crude production rates and deterioration of water quality for injection due to increase of total solids loading.
The objective of the study included developing the water treatment technology for removing the returned polymer, developing the pilot run for implementation of the technology and scaling up the process if the pilot shows success.
Crude processed at MPT is produced from Mangala, Bhagyam and Aishwarya fields which are located at the north-west part of India. Full field polymer flooding has been implemented in the Mangala field from 2015. Fouling of downhole and topside equipment with elastic deposits has been reported soon after polymer breakthrough the same year.
For reducing the fouling potential and solids loading, the concept of removing the returned polymer from produced water has been considered as beneficial.
Removal of polymer through the chemical coagulation was considered for developing. Extensive laboratory and bench testing have been carried out. Based on the laboratory results, the pilot was developed and carried out on the flotation equipment available at MPT.
In the laboratory and bench test for polymer coagulation, over 70% polymer removal was achieved with non-sticky flocks and minimal sludge. The tests also demonstrated reduced suspended solids, residual oil and filterability improvement of treated water.
The pilot run confirmed effectiveness of the chemical coagulation process to remove polymer. Polymer removal &gt; 70% was observed during the pilot. Oil removal from produced water at 60-80% was seen. Cloud point of polymer remaining in water increased from 60°C to &gt; 110°C indicating on the significant potential reduction of remaining polymer to precipitate from treated water.
The pilot results demonstrated on the applicability of the technology of chemical polymer removal at MPT and will be used for scaling up the treatment facilities.
Butterfly Glioblastoma - the Impact of Tumor Volumes and Treatment Strategies on Clinical Outcome
Authors: Bjorland Line Sagerup , Kurz Kathinka Dæhli , Fluge Fluge Øystein , Gilje Bjørnar , Mahesparan Rupavathana , Sætran Hege , Ushakova Anastasia , Farbu Elisabeth 
Published: December 2021

Abstract
PurposeButterfly glioblastoma is a rare subgroup of glioblastoma with a bihemispheric tumor crossing the corpus callosum, and is associated with a dismal prognosis. Prognostic factors are previously sparsely described and optimal treatment approaches remain uncertain. We aimed to analyse prognostic factors in butterfly glioblastoma, and to evaluate treatment strategies and outcome in a real-world setting.MethodsWe conducted a retrospective population-based cohort study of patients diagnosed with butterfly glioblastoma in Western Norway between 01/01/2007 and 31/12/2014. Clinical data were extracted from electronic medical records. Molecular and MRI volumetric analyses were retrospectively performed. Survival analyses were performed using Kaplan-Meier method and Cox proportional hazards regression models.ResultsAmong 381 patients diagnosed with glioblastoma, 33 patients (8.7%) met the criteria for butterfly glioblastoma. Median overall survival was 5.5 months (95% CI 3.1-7.9) and three-year survival was 9.1%. Older age and mainly deep-seated tumour location were associated with poor outcome, with adjusted hazard ratio (HR) 1.06 (95% CI 1.03-1.10), p<0.001, and adjusted HR 4.58 (95% CI 1.15-18.20), p=0.03. Best supportive care was associated with poorer survival compared to multimodal treatment (adjusted HR 5.11 (95% CI 1.09-23.89), p=0.04).ConclusionOutcome from butterfly glioblastoma was dismal, with a median overall survival of less than six months. However, long-term survival was comparable to that observed in glioblastoma in general, and multimodal treatment was associated with longer survival. This suggests that patients with butterfly glioblastoma may benefit from a more comprehensive treatment approach despite the overall poor prognosis.
Characterization and Classification of Soils and Water in Major Irrigated Lands of Lake Abaya Chamo Basin.
Authors: Gelu Gezimu , ayza alemnesh gelu gezimu , dane Chanako 
Published: December 2021

Abstract
Large amount of irrigated land under Lake Abaya Chamo basin is becoming unproductive every year because of salinity and sodicity expansion; consequently farmers are leaving their land out of cultivation due to burning of crops. For sustainable land use and Agricultural water management, it is a very important to examine the chemical composition of soils water and status of their quality. Therefore, the study was aimed to evaluate the physico-chemical properties of soils and irrigation water of irrigated lands under Lake Abaya Chamo basin, located in South East rift valley of Ethiopia. The pH of the soil in the study area ranged from (7.24 to 9.04, 7.54 to 7.91), Electrical conductivity (0.388 to 19.22, 0.644 to 23.6) under Lake Abaya and Chamo, respectively. The results of irrigation water quality showed that the water class of lake Abaya Chamo basin is under harzard status of salinity and sodicity and cannot be recommended for irrigation use. There is a potential danger of sodicity and salinity development in the intended lake basin. Thus, selection of salinity and sodicity resistant crop types, proper irrigation water application methods and other chemical mitigation measures should be designed for sustainability of soil and water productivity.
Dental Pulp Mesenchymal Stem Cells Promote Polarization of M2 Macrophages and Accelerate Wound Healing by Secreting CCL2
Authors: Yang Zi , Ma Linsha , Du Congling , Wang Jinsong , Zhang Chunmei , Hu Lei , Wang Songlin 
Published: December 2021

Abstract
Background
Mesenchymal stem cells (MSCs) are widely used in tissue engineering owing to their regenerative potential and immunomodulatory capacity. The crosstalk between MSCs and the host immune function plays a key role in the efficiency of tissue regeneration. However, the difference in immunological modulation and tissue regeneration function between MSCs from different sources remains unclear.
Methods
Human mesenchymal stem cells derived from bone marrow (BMMSCs), periodontal ligament (PDLSCs), adipose (ADSCs), and dental pulp (DPSCs) were obtained and induced to form cell sheets under the condition of 20 ug/ml vitamin C. The MSC cell sheets carried by hydroxyapatite/tricalciumphosphate (HA/TCP) particles were transplanted subcutaneously into C57BL6 mice for 8 weeks. Histological analyses were performed to detect the tissue regeneration potential and macrophages polarization in vivo. Then, THP-1 macrophages were co-cultured with MSCs and quantitative real-time polymerase chain reaction, immunofluorescent staining, western blotting, and enzyme-linked immunosorbent assay were used to investigate the function and mechanism of MSCs on macrophages in vitro. Finally, a wound healing model of the palatal mucosa was performed to confirm the effect of MSCs on macrophages and tissue healing efficiency.
Results
Compared to PDLSCs, BMMSCs, and ADSCs, DPSCs exhibited greater tissue regeneration potential, with greater tissue volume, higher Ki67 expression, and less apoptosis in the regenerated tissue of wild-type C57BL6 mice. In addition, DSPCs triggered more M2 macrophages in the regenerated tissue than other MSCs. Our data showed that DPSCs exhibited higher expression levels of C-C Motif Chemokine Ligand 2 (CCL2), and specific blocking of CCL2 by neutralising antibodies can significantly inhibit the DPSCs-induced polarization of M2 macrophages. Finally, DPSCs transplantation promoted wound healing of the palatal mucosa and M2 macrophages polarization in vivo, which could be significantly impaired by CCL2 neutralising antibody.
Conclusions
Our data indicate that DPSCs exert better tissue regeneration potential and immunoregulatory function by secreting CCL2. These results suggest that CCL2 application can enhance MSC-mediated tissue regeneration or wound healing.
The Alcohol Flushing Response is Associated with the Risk of Depression
Authors: Jeon Seonghee , Kang Heewon , Cho Inhyung , Cho Sung-il 
Published: December 2021

Abstract
The alcohol flushing response is experienced by 36–45% of East Asians after drinking a small amount of alcohol. Since individuals with this response are incapable of metabolizing toxic acetaldehyde derived from alcohol effectively, this response is suggested as an indicator for the health risks associated with alcohol intake. Depression, a major health problem linked to alcohol consumption, might also be associated with the presence of the alcohol flushing response. Therefore, this study examined the association between the alcohol flushing response and the risk of depression in the general population of South Koreans. The analysis included 139,266 participants and used data from the 2019 Korean Community Health Survey. Only current drinkers were considered in the analysis. The relationship between the alcohol flushing response and depression was determined by logistic regression analysis using SAS 9.4. As a result, more than one-third of the population was found to be current flushers, and the relationship was significant among current flushers and depression (AOR=1.23, 95% CI 1.12–1.35, P-value=0.1ⅹ10-3) compared to never flushers. No association was found between former flushing response and depression. The odds of depression were significantly higher among alcohol flushers who drinks less than 15 g/day alcohol (<5 g/day: AOR=1.21, 95% CI=1.08-1.36, P-value=0.1ⅹ10-3; 5.0-14.9 g/day: AOR=1.40, 95% CI=1.14-1.71, P-value=0.1ⅹ10-3). In conclusion, this study reveals that a significant number of the South Korean population experiences the alcohol flushing response, and the individuals with the response are more likely to feel depressed, even with a small amount of alcohol consumption.
Identification of Polymorphisms in GDF9 and BMP15 Genes in Jamunapari and Crossbred Goats in Bangladesh
Authors: Shaha Mishuk , Miah Gous , Lima Arjuman , Miazi Omar Faruk , Das Ashutosh 
Published: December 2021

Abstract
Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are two crucial fecundity genes 15 associated with litter size traits in the goat. Our previous study on GDF9 and BMP15 genes detected single nucleotide polymorphisms (SNPs) associated with litter size in Bangladeshi Black Bengal goats. In this study, Jamunapari and crossbred goats of Bangladesh were screened to identify polymorphisms in the GDF9 and BMP15 genes and to assess the association between identified SNPs and litter size. The genomic DNA from 100 goats (50 Jamunapari and 50 crossbred) was used in Polymerase Chain Reaction (PCR) to amplify the exon 2 of the GDF9 and exon 2 of the BMP15 gene. PCR products were sequenced employing the BigDye Terminator cycle sequencing protocol, to identify SNPs. A generalized linear model was utilized to perform the association analysis for identified SNPs and litter size. Seven SNPs were identified, of which four: C818CT, G1073A, G1189A and G1330T were in the GDF9 gene, three: G616T, G735A and G811A were in the BMP15 gene. G735A was a synonymous SNP, whereas the remaining were non-synonymous SNPs. Identified SNP loci in GDF9 were low polymorphic (PIC<0.25) while loci in BMP15 were moderately polymorphic (PIC≥0.25). The genotypes at the G1330T locus had a significant (p<0.05) difference in litter size in Jamunapari goat, but no significant difference was observed for all genotypes at other loci. This study provides additional molecular markers that would be useful for future research on the litter size trait in goats of Bangladesh.
Exploring the Functional and Metabolic Effects of Feeding Garra Fish Meal to Broiler Chickens
Authors: Mebratu Awot Teklu , Asfaw Yohannes Tekle , Janssens Geert Paul Jules 
Published: December 2021

Abstract
The present study evaluated the metabolic and functional effects, beyond nutritive value, of feeding garra meal to broiler chickens. Three hundred twenty Sasso-breed day-old chicks were randomly assigned to four dietary treatments with either 0, 10, 20 or 30% garra meal added on top of a formulated starter and grower basal diets. The experiment lasted for 42 days. There was a gradual increase in feed intake and body weight gain with increasing garra meal addition (p < 0.05). Broiler chickens fed 30% garra meal were more efficient in converting feed to body weight and yielded the highest carcass weight (p < 0.05). Crude protein and crude fat digestibility coefficients were higher with the garra meal receiving groups with the highest values (74.8 ± 1.6 and 92.3 ± 0.6) recorded with 20% and 30% garra meal additions, respectively (p < 0.05). The increase in individual and total esterified carnitine concentrations in dried blood spots demonstrated the elevated metabolic rate with increasing garra meal addition (p < 0.05). A better supply of glucogenic substrate to the citric acid cycle was seen with garra meal addition due to the increase of propionylcarnitine to acetylcarnitine ratio (p < 0.05) while no effect was observed on ketogenesis as measured through the 3-hydroxybutyrylcarnitine to acetylcarnitine ratio (p > 0.05). Yet, it likely showed that part of the higher amino acids (Leucine, Methionine and Citrulline) uptake due to garra meal was used as glucogenic substrate (p < 0.05). Histo-morphology showed gradual increases in villus height, crypt depth and their ratio in the proximal parts of the intestine (duodenum and jejunum) with the opposite results observed in the more distal part (ileum) with garra meal addition (p < 0.05). It can be concluded that garra meal strongly improved broiler performance when added to a plant-based diet and only few parameters warranted for caution when using more up to 30% garra meal addition. Beyond growth performance, garra meal generated a shift to a more efficient digestion and nutrient metabolism, and induced changes in edible muscle that may aid in solving shortages in the Ethiopian human diet.