bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of physical distancing on Covid-19 incidence in Brazil: does the strictness of mandatory rules matter?
Authors: Guimarães Raphael Mendonça , Monteiro da Silva José Henrique Costa , Brusse Gustavo Pedroso de Lima , Martins Thalyta Cássia de Freitas 
Published: September 2021

Abstract
This study aims to examine the association between physical distancing measures and coronavirus disease 2019 (COVID-19) incidence among Brazilian states. We divided the methodology was divided into three steps. In the first step, we used nationwide global positioning system daily data to estimate country and state-level physical distancing and examined the association with COVID-19 incidence through a Generalized Additive Model. Secondly, using National Household Sample Survey COVID19 data, a cluster analysis categorized the Brazilian states into different categories of physical distancing policies promoting adoption and political inclination of their governments. Finally, through a Poisson Regression Model, we examined the association of state physical distancing with variables related to the socio-economic situation, test coverage and early adoption of policies promoting physical distancing of each state. Physical distancing effects on reduction of COVID-19 spread are heterogeneous among states. Estimation of incidence rate ratio (IRR) suggests that in a scenario of 100% of social isolation incidence of COVID-19 will have reached approximately only 2.6% of the magnitude compared to when there is no social isolation for Brazil [95% confidence interval (CI) 0.8–8.3]. Only a 10% increase in Social Isolation Index in the country could have reflected in a 30.5% decrease in number of cases in 14 days. Adoption of physical distancing was associated with test coverage (IRR 0.976, 95% CI 0.973–0.979), home office (IRR 1.042, 95% CI 1.039–1.046), informal work proportion (IRR 0.961, 95% CI 0.958–0.965), political spectrum (IRR 0.961, 95% CI 0.958–0.965) and early moment of restrictive politics implementation (IRR 1.017, 95% CI 1.013–1.021). Physical distancing measures play a crucial role in mitigating the pandemic’s spread. These analyses are crucial to support government decisions and improve the community’s adherence to preventive measures.
Use of antidepressants and endometrial-cancer risk: a nationwide nested case–control study
Authors: Sperling Cecilie D , Aalborg Gitte L , Dehlendorff Christian , Friis Søren , Mørch Lina S , Kjaer Susanne K 
Published: September 2021

AbstractBackgroundPreclinical studies have suggested that antidepressant drugs may possess antineoplastic properties. In a nationwide case–control study, we examined the association between use of antidepressants and endometrial-cancer risk with a particular focus on selective serotonin reuptake inhibitors (SSRIs).MethodsFrom the Danish Cancer Registry, we identified all women with a histologically verified diagnosis of endometrial cancer between 2000 and 2016, and, for each woman, 15 age-matched controls. We obtained information on use of SSRIs, tricyclic antidepressants (TCAs) and other antidepressants based on records of filled prescriptions from the National Prescription Register. Using conditional logistic regression, we calculated adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for associations between use of antidepressants and endometrial-cancer risk compared with non-use. In active comparator analyses, SSRI use was compared with TCA use.ResultsThe study population comprised 8164 cases and 122 432 controls. Compared with non-use, SSRI use was associated with an OR of 0.88 (95% CI 0.82–0.96) for endometrial cancer, whereas the association with TCA use was close to unity (OR 1.05, 95% CI 0.90–1.22). Use of other antidepressants yielded an OR of 0.86 (95% CI 0.71–1.03). We observed no apparent trends in associations according to cumulative amount. The inverse association with SSRI use persisted when compared with TCA use (OR 0.81, 95% CI 0.66–0.99).ConclusionsUse of SSRIs was associated with a decreased risk of endometrial cancer, whereas no inverse association appeared with use of TCAs. The antineoplastic potential of SSRIs should be investigated in future studies.
The quality of social determinants data in the electronic health record: a systematic review
Authors: Cook Lily A , Sachs Jonathan , Weiskopf Nicole G 
Published: September 2021

AbstractObjectiveThe aim of this study was to collect and synthesize evidence regarding data quality problems encountered when working with variables related to social determinants of health (SDoH).Materials and MethodsWe conducted a systematic review of the literature on social determinants research and data quality and then iteratively identified themes in the literature using a content analysis process.ResultsThe most commonly represented quality issue associated with SDoH data is plausibility (n = 31, 41%). Factors related to race and ethnicity have the largest body of literature (n = 40, 53%). The first theme, noted in 62% (n = 47) of articles, is that bias or validity issues often result from data quality problems. The most frequently identified validity issue is misclassification bias (n = 23, 30%). The second theme is that many of the articles suggest methods for mitigating the issues resulting from poor social determinants data quality. We grouped these into 5 suggestions: avoid complete case analysis, impute data, rely on multiple sources, use validated software tools, and select addresses thoughtfully.DiscussionThe type of data quality problem varies depending on the variable, and each problem is associated with particular forms of analytical error. Problems encountered with the quality of SDoH data are rarely distributed randomly. Data from Hispanic patients are more prone to issues with plausibility and misclassification than data from other racial/ethnic groups.ConclusionConsideration of data quality and evidence-based quality improvement methods may help prevent bias and improve the validity of research conducted with SDoH data.
Determination of Sulphasalazine and Its Related Compounds by Simple, Smart, Validated, Green Spectrophotometric Methods
Authors: Abdelwhab Nada S , Habib Neven M , Abdelrahman Maha M , Mahmoud Hamada M , Emam Aml A 
Published: September 2021

AbstractBackgroundSulphasalazine (SZ) is a prodrug. Its active metabolite (mesalazine, MZ), which is also available in pharmaceutical formulations, and the major active metabolite of MZ (N-acetyl-5-aminosalicylic acid, AS) are commonly used for the treatment of inflammatory bowel diseases.ObjectiveTwo accurate, precise, sensitive, and specific spectrophotometric methods were developed and validated for determination of the studied components.MethodsThe first method is a modified ratio difference spectrophotometric method. In this method, SZ was determined by measuring the peak area from 410–500 nm, while MZ and AS were determined by measuring the difference of the selected amplitude values. The second method is a mean centering of ratio spectra spectrophotometric method.ResultsThe developed methods were linear over the concentration ranges of 2–35, 2–30 and 1–25 µg/mL for SZ, MZ and AS, respectively.ConclusionThe developed methods were validated according to International Conference on Harmonization guidelines. They were successfully applied for determination of studied analytes. A greenness assessment was undertaken using three different tools.HighlightsSpectrophotometric methods were developed for determination of SZ and its related compounds for the first time. They were designated to be green and eco-friendly and their greenness profiles were evaluated using green solvents to keep the environment clean.
Epitope-dependent thermodynamic signature of single-domain antibodies against hen egg lysozyme
Authors: Akiba Hiroki , Tamura Hiroko , Caaveiro Jose M M , Tsumoto Kouhei 
Published: September 2021

Abstract
A substantial body of work has been carried out describing the structural features of the complex between single-domain antibodies (VHHs) and antigens, and the preeminence for epitopes located at concave surfaces of the antigen. However, the thermodynamic basis of binding is far less clear. Here, we have analysed the energetic profiles of five VHHs binding to the catalytic cleft or to a noncleft epitope of hen egg lysozyme. Various binding energetic profiles with distinctive enthalpic/entropic contributions and structural distribution of critical residues were found in the five antibodies analysed. Collectively, we suggest that from an energetic point of view the binding mechanism is influenced by the shape of the epitope. This information may be beneficial for the design of tailored epitopes for VHHs and their practical use.
When in Rome... On Local Norms and Sentencing Decisions
Authors: Abrams David , Galbiati Roberto , Henry Emeric , Philippe Arnaud 
Published: September 2021

Abstract
We study spatial variation in criminal sentencing. We show the existence of local sentencing practices varying widely even across geographically proximate areas. Using compulsory rotation of judges in North Carolina, we find that judges arriving in a new court gradually converge toward local sentencing practices. We provide evidence that convergence in sentencing corresponds to a process of learning about local practices, which is accelerated by the presence of senior judges in the district, and that these sentencing practices are correlated with local norms of behavior. Finally, we discuss the theoretical implications of these results for the optimal design of judicial systems.
Receptivity to a Nurse-Led Symptom Management Intervention Among Highly Symptomatic Patients With Cancer
Authors: Wintheiser Grant A , Ruddy Kathryn J , Herrin Jeph , Rahman Parvez A , Pachman Deirdre R , Leppin Aaron L , Rutten Lila J Finney , Lee Minji K , Griffin Joan M , Tofthagen Cindy , Chlan Linda L , Ridgeway Jennifer L , Mitchell Sandra A , Cheville Andrea L 
Published: September 2021

Abstract

Background
The symptom burden associated with cancer and its treatment can negatively affect patients’ quality of life and survival. Symptom-focused collaborative care model (CCM) interventions can improve outcomes, but only if patients engage with them. We assessed the receptivity of severely symptomatic oncology patients to a remote nurse-led CCM intervention.

Methods
In a pragmatic, cluster-randomized, stepped-wedge trial conducted as part of the National Cancer Institute IMPACT Consortium (E2C2, NCT03892967), patients receiving cancer care were asked to rate their sleep disturbance, pain, anxiety, emotional distress, fatigue, and limitations in physical function. Patients reporting at least 1 severe symptom (≥7/10) were offered phone consultation with a nurse symptom care manager (RN SCM). Initially, patients had to “opt-in” to receive a call, but the protocol was later modified so they had to “opt-out” if they did not want a call. We assessed the impact of opt-in vs opt-out framing and patient characteristics on receptiveness to RN SCM calls. All statistical tests were 2-sided.

Results
Of the 1204 symptom assessments (from 864 patients) on which at least 1 severe symptom was documented, 469 (39.0%) indicated receptivity to an RN SCM phone call. The opt-out period (odds ratio [OR] = 1.61, 95% confidence interval [CI] = 1.12 to 2.32, P = .01), receiving care at a tertiary care center (OR = 3.59, 95% CI = 2.18 to 5.91, P &lt; .001), and having severe pain (OR = 1.80, 95% CI = 1.24 to 2.62, P = .002) were associated with statistically significantly greater willingness to receive a call.

Conclusions
Many severely symptomatic patients were not receptive to an RN SCM phone call. Better understanding of reasons for refusal and strategies for improving patient receptivity are needed.
Rosette-Forming Glioneuronal Tumor in the Pineal Region: A Series of 6 Cases and Literature Review
Authors: Lin Chun-Chieh , Mansukhani Mahesh M , Bruce Jeffrey N , Canoll Peter , Zanazzi George 
Published: September 2021

Abstract
Resected lesions from the pineal region are rare specimens encountered by surgical pathologists, and their heterogeneity can pose significant diagnostic challenges. Here, we reviewed 221 pineal region lesions resected at New York-Presbyterian Hospital/Columbia University Irving Medical Center from 1994 to 2019 and found the most common entities to be pineal parenchymal tumors (25.3%), glial neoplasms (18.6%), and germ cell tumors (17.6%) in this predominantly adult cohort of patients. Six cases of a rare midline entity usually found exclusively in the fourth ventricle, the rosette-forming glioneuronal tumor, were identified. These tumors exhibit biphasic morphology, with a component resembling pilocytic astrocytoma admixed with variable numbers of small cells forming compact rosettes and perivascular pseudorosettes. Targeted sequencing revealed a 100% co-occurrence of novel and previously described genetic alterations in the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling pathways, suggesting a synergistic role in tumor formation. The most common recurrent mutation, PIK3CA H1047R, was identified in tumor cells forming rosettes and perivascular pseudorosettes. A review of the literature revealed 16 additional cases of rosette-forming glioneuronal tumors in the pineal region. Although rare, this distinctive low-grade tumor warrants consideration in the differential diagnosis of pineal region lesions.
Nuclear IMPDH Filaments in Human Gliomas
Authors: Ahangari Narges , Munoz David G , Coulombe Josee , Gray Douglas A , Engle Elizabeth C , Cheng Long , Woulfe John 
Published: September 2021

Abstract
The analysis of nuclear morphology plays an important role in glioma diagnosis and grading. We previously described intranuclear rods (rods) labeled with the SDL.3D10 monoclonal antibody against class III beta-tubulin (TUBB3) in human ependymomas. In a cohort of adult diffuse gliomas, we identified nuclear rods in 71.1% of IDH mutant lower-grade gliomas and 13.7% of IDH wild-type glioblastomas (GBMs). The presence of nuclear rods was associated with significantly longer postoperative survival in younger (≤65) GBM patients. Consistent with this, nuclear rods were mutually exclusive with Ki67 staining and their prevalence in cell nuclei inversely correlated with the Ki67 proliferation index. In addition, rod-containing nuclei showed a relative depletion of lamin B1, suggesting a possible association with senescence. To gain insight into their functional significance, we addressed their antigenic properties. Using a TUBB3-null mouse model, we demonstrate that the SDL.3D10 antibody does not bind TUBB3 in rods but recognizes an unknown antigen. In the present study, we show that rods show immunoreactivity for the nucleotide synthesizing enzymes inosine monophosphate dehydrogenase (IMPDH) and cytidine triphosphate synthetase. By analogy with the IMPDH filaments that have been described previously, we postulate that rods regulate the activity of nucleotide-synthesizing enzymes in the nucleus by sequestration, with important implications for glioma behavior.
Research on the evaluation of museum website utility index based on analytic hierarchy process: a case study of China's national first-class museums
Authors: Ma Xintao , Hu Yuna 
Published: September 2021

AbstractIn order to better serve the construction and development of museum websites in developing countries, and based on the user's online experience perspective, an analytic hierarchy process suitable for the construction of a museum website for developing counties utility index evaluation system was used to measure the official websites of 115 national first-class museums in China, and reflect the level of museum website construction and service levels. The results revealed the following: there were obvious differences in the level of a Chinese museum construction sites, showing an overall Rugby-type distribution situation; content completeness and update speed are the most important factors that affect the measurement of the museum website's utility index, which fully reflects the importance of the comprehensiveness, accuracy and timeliness of the website information in the construction of a museum website; the influence is that museum websites are generally weak, with limited spread and power, and fails to form a large positive social influence; the construction problems are mainly concentrated in the two aspects of technology and operation. The display, safety and security technology of the museum website content is relatively backward, and most of the website backgrounds rarely have professionals for daily visitor interaction and operation, and maintenance. The results of the index measured by this system not only allows museum personnel to clearly understand the gaps in the development of museum websites, but also provides more clear requirements for future personnel to design, build and improve the overall usefulness of the website or a single utility index in a targeted manner, which has important guiding significance and practical value.
Exploring the similarity between Han’s and non-Han’s Yuan poetry: Resistance distance metrics over character co-occurrence networks
Authors: Yang Yi , Song Yue 
Published: September 2021

Abstract
The Yuan dynasty is the first non-Han unified dynasty in ancient China. It is subtle to tell the similarities and differences between the classic Chinese poems in the Yuan dynasty written by the writers of Han nationality and non-Han minority nationalities. By graph theory and statistics, this article establishes a novel method for quantifying the similarity between the Han’s and non-Han’s Yuan poetry. First, we formulate the character co-occurrence networks (CCONs) of the Han’s and non-Han’s Yuan poem databases collected from ‘Database of Ancient Chinese Classics’. The resistance distance, a graph theory concept, is introduced to describe the lexical relation between a pair of characters in the CCONs. Then, we propose the similarity index as the coefficient of variation for the ratios of resistance distances in the CCONs of Han’s and non-Han’s poem databases, which measures the consistency between the usages of characters in the Han’s and non-Han’s poems. The calculation results indicate that the Han’s and non-Han’s poems share a high percentage of common high-frequency characters and there do not exist significantly different lexical features in terms of the usage of these high-frequency characters. The obtained results offer new insights into the quantitative features of this long-debated issue.
NLRP3 promotes endometrial receptivity by inducing epithelial–mesenchymal transition of the endometrial epithelium
Authors: Cheng Xi , Zhang Yu , Ma Jinzhao , Wang Shuxian , Ma Rujun , Ge Xie , Zhao Wei , Xue Tongmin , Chen Li , Yao Bing 
Published: September 2021

ABSTRACT
Endometrial receptivity is crucial for successful embryo implantation. It is regulated by multiple factors which include ovarian steroid hormones and the immune microenvironment among others. Nod-Like Receptor Pyrins-3 (NLRP3) is a key intracellular pattern-recognition receptor and a critical component of the inflammasome, which plays an essential role in the development of inflammation and of immune responses. However, the physiological functions of NLRP3 in the endometrium remain largely unclear. This study investigated the physiological and pathological significance of NLRP3 in human endometrial epithelial cell during the implantation window. NLRP3 is highly expressed during the mid-proliferative and mid-secretory phases of the human endometrium and transcriptionally up-regulated by estradiol (E2) through estrogen receptor β (ERβ). In addition, NLRP3 promotes embryo implantation and enhances epithelial-mesenchymal transition (EMT) of Ishikawa (IK) cells via both inflammasome-dependent and inflammasome-independent pathways, which might provide a novel insight into endometrial receptivity and embryo implantation. Our findings suggest that NLRP3, which is transcriptionally regulated by E2, induces epithelial–mesenchymal transition of endometrial epithelial cells and promotes embryo adhesion.
PL03.4.A Factors associated with health-related quality of life (HRQoL) deterioration in glioma patients during the progression-free survival period
Authors: Coomans M , Dirven L , Aaronson N , Baumert B , van den Bent M , Bottomley A , Brandes A , Chinot O , Coens C , Gorlia T , Herrlinger U , Keime-Guibert F , Malmström A , Martinelli F , Stupp R , Talacchi A , Wick W , Reijneveld J , Taphoorn M 
Published: September 2021

Abstract

BACKGROUND
Maintenance of functioning and wellbeing during the progression-free survival (PFS) period is important for glioma patients. This study aimed to determine whether health-related quality of life (HRQoL) can be maintained during progression-free time, and factors associated with HRQoL deterioration in this period.

MATERIAL AND METHODS
We included longitudinal HRQoL data from previously published clinical trials in glioma. The percentage of patients with stable HRQoL until progression was determined per scale and at the individual patient level (i.e. considering all scales simultaneously). We assessed time to a clinically relevant deterioration in HRQoL, expressed in deterioration-free survival and time-to-deterioration (the first including progression as an event). We also determined the association between sociodemographic and clinical factors and HRQoL deterioration in the progression-free period.

RESULTS
5539 patients with at least baseline HRQoL scores had a median time from randomization to progression of 7.6 months. Between 9%-29% of the patients deteriorated before disease progression on the evaluated HRQoL scales. When considering all scales simultaneously, 47% of patients deteriorated on ≥1 scale. Median deterioration-free survival period ranged between 3.8–5.4 months, and median time-to-deterioration between 8.2–11.9 months. For most scales, only poor performance status was independently associated with clinically relevant HRQoL deterioration in the progression-free period.

CONCLUSION
HRQoL was maintained in only 53% of patients in their progression-free period, and treatment was not independently associated with this deterioration in HRQoL. Routine monitoring of the patients’ functioning and well-being during the entire disease course is therefore important, so that interventions can be initiated when problems are signalled.