bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of Piezoelectric Properties of Ag-NPs Doped PVDF
Nanocomposite Fibres Membrane Prepared by Near Field Electrospinning
Authors: Pan Cheng-Tang , Dutt Karishma , Yen Chung-Kun , Kumar Ajay , Kaushik Aman Chandra , Wei Dong-Qing , Kumar Amit , Wen Zhi-Hong , Hsu Wen-Hsin , Shiue You-Ling 
Published: March 2021

Background:
In this study, Near-field electrospinning (NFES) technique used with a cylindrical collector to fabricate a large area permanent piezoelectric micro and nanofibers by a prepared solution. NFES requires a small electric field to fabricate fibers.

Objective:
The objective of this paper to investigate silver nanoparticle (Ag-NP)/ Polyvinylidene fluoride (PVDF) composite as the best piezoelectric material with improved properties to produced tremendously flexible and sensitive piezoelectric material with pertinent conductance.

Method:
In this paper we used controllable electrospinning technique based on Near-field electrospinning (NFES)The process parameter for Ag-NP/PVDF composite electrospun fiber based on pure PVDF fiber. A PVDF solution concentration of 18 wt.% and 6 wt.% silver nitrate which is relative to the weight of PVDF wt.% with 1058 µS conductivity fibers have been directly written on a rotating cylindrical collector for aligned fiber PVDF/Ag-NP fibers are patterned on fabricated copper (Cu) interdigitated electrodes were implemented on a thin flexible polyethylene terephthalate (PET) substrate and Polydimethylsiloxane (PDMS) used as a package to enhance the durability of the PVDF/ Ag-NP device.

Results:
A notable effect on the piezoelectric response has been observed after Ag-NP addition confirmed by XRD characterization and tapping test of Ag-NP/PVDF composite fiber. The morphology of the PVDF/Ag-NP fibers and measure diameter by scanning electron microscopy (SEM) and Optical micrograph (OM), of fiber. Finally, The result shows that diameter of PVDF/Ag-NP fibers up to ~7 μm. The. High diffraction peak at 2θ = 20.5˚ was investigated by X-ray diffraction (XRD) in the piezoelectric crystal β-phase structure. While the electromechanical conversion is found enhance from ~0.1 V to ~1 V by the addition of silver nanoparticles (Ag-NPs) in the PVDF solution.

Conclusion:
In conclusion, we can say that confirmed and validated the addition of Ag-NP in PVDF could enhance the piezoelectric property by using NFES technique with improved crystalline phase content can be useful for a wide range of power and sensing applications like biomedical devices and energy harvesting, among others.
Identification of a Novel Epithelial-to-mesenchymal-related Gene Signature
in Predicting Survival of Patients with Hepatocellular Carcinoma
Authors: Zheng Guohua , Xiao Simeng , Hu Junjie , Hu Na , Sheng Lei , Rao Hui 
Published: March 2021

Background:
Epithelial-mesenchymal transformation (EMT) promotes cancer
metastasis, including hepatocellular carcinoma. Therefore, EMT-related gene signature was
explored.

Objective:
The present study was designed to develop an EMT-related gene signature for
predicting the prognosis of patients with hepatocellular carcinoma.

Methods:
An integrated gene expression analysis based on tumor data of the patients with
hepatocellular carcinoma from The Cancer Genome Atlas (TCGA), HCCDB18, and GSE14520
dataset was conducted. An EMT-related gene signature was constructed by the least absolute
shrinkage and selection operator (LASSO) and COX regression analysis of univariate and
multivariate survival.

Results:
A 3-EMT gene signature was developed and validated based on gene expression profiles
of hepatocellular carcinoma from three microarray platforms. Patients with a high-risk score had
significantly worse overall survival (OS) than those with low-risk scores. The EMT-related gene
signature showed a high performance in accurately predicting prognosis and examining the clinical
characteristics and immune score analysis. Univariate and multivariate Cox regression analyses
confirmed that the EMT-related gene signature was an independent prognostic factor for predicting
survival in hepatocellular carcinoma patients. Compared with the existing models, our EMTrelated
gene signature reached a higher area under the curve (AUC).

Conclusion:
Our findings provide novel insight into understanding EMT and help identify
hepatocellular carcinoma patients with poor prognosis.
Leukaemia Infection Diagnosis and Intestinal Flora Disorder
Authors: Wang Hongwu , Zhong Yong , Ma Lian 
Published: March 2021

:
Leukaemia is the most common malignant tumor in childhood and can be cured by chemotherapy. Infection is an important cause of treatment-related death and treatment failure in childhood leukaemia. Recent studies have shown that the correlation between the occurrence of leukaemia infection and the intestinal flora has attracted more and more attention. Intestinal flora can affect the body's physiological defense and immune function. When intestinal microflora disorder occurs, metabolites/microorganisms related to intestinal flora alterations and even likely the associated morpho-functional alteration of the epithelial barrier may be promising diagnostic biomarkers for the early diagnosis of leukaemia infection. This review will focus on the interaction between leukaemia infection and intestinal flora, and the influence of intestinal flora in the occurrence and development of leukaemia infection.
Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) During Pregnancy and the Risk for Autism spectrum disorder (ASD) and Attention deficit hyperactivity disorder (ADHD) in the Offspring: A True Effect or a Bias? A Systematic Review & Meta-Analysis
Authors: Leshem Regina , Bar-Oz Benjamin , Diav-Citrin Orna , Gbaly Siham , Soliman Jessica , Renoux Christel , Matok Ilan 
Published: March 2021

Background and Objective:
An inconsistent association between exposure to SSRIs and
SNRIs and the risk for ASD and ADHD in the Offspring was observed in observational studies.
Some suggest that the reported association might be due to unmeasured confounding. We aimed to
study this association and to look for sources of bias by performing a systematic review and meta-analysis.

Methods:
Medline, Embase, and the Cochrane Library were searched up to June 2019 for studies
reporting on ASD and ADHD in the Offspring following exposure during pregnancy. We followed
the PRISMA 2009 guidelines for data selection and extraction. Outcomes were pooled using random-
effects models and odds ratios (OR), and 95% confidence intervals (CI) were calculated for
each outcome using the adjusted point estimate of each study.

Results:
Eighteen studies were included in the meta-analysis. We found an association between SSRIs/
SNRIs prenatal use and the risk for ASD and ADHD (OR=1.42, 95% CI: 1.23–1.65, I2=58%;
OR=1.26, 95% CI: 1.07-1.49, I2=48%, respectively). Similar findings were obtained in women
who were exposed to SSRIs/SNRIs before pregnancy, representing statistically significant association
with ASD (OR=1.39, 95% CI: 1.24-1.56, I2=33%) and ADHD (OR=1.63, 95% CI: 1.50-1.78,
I2=0%) in the Offspring, although they were not exposed to those medications in utero.

Conclusions:
Although we found an association between exposure to SSRIs/SNRIs during pregnancy
and the risk for ASD and ADHD, an association with those disorders was also present for exposure
pre-pregnancy, suggesting that the association might be due to unmeasured confounding.
We are aiming to further assess the role of potential unmeasured confounding in the estimation of
the association and perform a network meta-analysis.
The Role of Imaging in Computer-Assisted Tumor Surgery of the Sacrum and Pelvis
Authors: Sambri Andrea , Fujiwara Tomohiro , Fiore Michele , Giannini Claudio , Zucchini Riccardo , Cevolani Luca , Donati Davide Maria , De Paolis Massimiliano 
Published: March 2021

:
The use of a navigation system allows precise resection of a tumor and accurate reconstruction of the resultant defect thereby sparing important anatomical structures and preserving function.
It is an “image-based” system where the imaging (computed tomography and magnetic resonance imaging) is required to supply the software with data. The fusion of the preoperative imaging provides pre-operative information about local anatomy and extent of the tumor, so that it allows an accurate preoperative planning. Accurate pre-operative imaging is mandatory in order to minimize CATS errors, thus performing accurate tumor resections.
Quality of Life of Healthcare Workers Suffering from Occupational Contact
Dermatitis
Authors: Omrane Amira , Khedher Asma , Harrathi Chayma , Maoua Maher , Khalfallah Taoufik , Bouzgarrou Lamia , Mrizak Nejib , Henchi Mohamed Adnene , Ali Hichem Bel Hadj 
Published: March 2021

Background:
Healthcare workers are at a high risk of developing Occupational Dermatitis
(OD). Affected workers often experience severe impairment of their Quality of Life (QoL). This
study aimed to assess the skin-related QoL of healthcare workers with OD and to explore its related
factors.

Methods:
A cross-sectional and exhaustive study was conducted among healthcare personnel of
four public hospitals in the central region of Tunisia. All the cases of OD declared were included.
Skin-related QoL was assessed using the validated Tunisian version of the “Dermatology Life Quality
Index” (DLQI). Some related patents have also been discussed.

Results:
A total of 37 cases of OD were collected with an annual incidence of 4.2 cases per 10000
workers. The population was predominantly female (73%) and the mean age was 44.7±9.4 years.
Nurses were the most represented occupational category (38%). Allergic contact dermatitis was the
most frequent diagnosis (96%). The use of gloves was the most frequently reported occupational
hazard (86%). The most frequently affected sites were hands (97%).
The median score of DLQI was five. Multivariate analysis showed an association between the impairment
of skin-related QoL and female gender (p = 0.04; OR = 19.3,84), exposure to disinfecting
chemicals in the workplace (p = 0.01; OR = 17,306) and the absence of occupational reclassification
(p = 0.01; OR = 21,567).

Conclusion:
About one-third of the population had an impaired quality of life. The score impairment
was significantly related to the female gender, exposure to disinfecting chemicals and the
absence of occupational reclassification.
TEKNOLOGI DAN MASA DEPAN OTONOMI MANUSIA: SEBUAH KAJIAN FILSAFAT MANUSIA
Authors: Cathrin Shely 
Published: March 2021

Penulisan artikel ini dilatarbelakangi oleh fenomena relasi manusia dengan teknologi akibat pesatnya perkembangan teknologi, komunikasi, dan informasi pada abad ke-21. Tujuan penulisan artikel ini adalah untuk melakukan refleksi atas teknologi dalam kajian filsafat manusia untuk memperdalam pemahaman tentang diri manusia. Artikel ini merupakan kajian pustaka dengan objek material berupa fenomena penggunaan gadget yang dianalisis dari objek formal filsafat manusia. Hasil studi menunjukkan bahwa teknologi pada dasarnya bersifat material atau berdimensi material. Roh manusia-lah yang menentukan arah dari teknologi itu. Betapa pun gadget membawa kebaikan pada manusia, ia adalah perangkat yang membahayakan. Ia mempunyai logikanya sendiri; arah tujuannya ditentukan berdasarkan rutenya sendiri; dan ia meleburkan manusia pada sebuah sistem yang otonom. Kata kunci untuk tetap menjaga otonomi manusia atas teknologi adalah pada kesadaran manusia. Pertama, manusia harus sadar bahwa teknologi perlu diperlakukan layaknya subjek; dan kedua, manusia harus sadar bahwa teknologi ada untuk manusia, sebagai sarana atau media untuk me-material-kan ide-ide dan gagasan manusia. Semuanya mengarah pada satu tujuan: demi membuat dunia manusia sesuai dengan kebutuhan manusia. Dengan berpegang pada dua hal tersebut, maka otonomi manusia atas teknologi akan tetap ada. Manusia tidak boleh jatuh pada teknologi karena teknologi untuk manusia bukan sebaliknya. Kata kunci: Teknologi, Gadget, Manusia, Otonomi, Kesadaran
e-Learning for Instruction and to Improve Reproducibility of Scoring Tumor-Stroma Ratio in Colon Carcinoma: Performance and Reproducibility Assessment in the UNITED Study
Authors: Smit Marloes A , van Pelt Gabi W , Dequeker Elisabeth MC , Al Dieri Raed , Tollenaar Rob AEM , van Krieken J Han JM , Mesker Wilma E ,   UNITED Group
Published: March 2021

Background
The amount of stroma in the primary tumor is an important prognostic parameter. The tumor-stroma ratio (TSR) was previously validated by international research groups as a robust parameter with good interobserver agreement.

Objective
The Uniform Noting for International Application of the Tumor-Stroma Ratio as an Easy Diagnostic Tool (UNITED) study was developed to bring the TSR to clinical implementation. As part of the study, an e-Learning module was constructed to confirm the reproducibility of scoring the TSR after proper instruction.

Methods
The e-Learning module consists of an autoinstruction for TSR determination (instruction video or written protocol) and three sets of 40 cases (training, test, and repetition sets). Scoring the TSR is performed on hematoxylin and eosin–stained sections and takes only 1-2 minutes. Cases are considered stroma-low if the amount of stroma is ≤50%, whereas a stroma-high case is defined as >50% stroma. Inter- and intraobserver agreements were determined based on the Cohen κ score after each set to evaluate the reproducibility.

Results
Pathologists and pathology residents (N=63) with special interest in colorectal cancer participated in the e-Learning. Forty-nine participants started the e-Learning and 31 (63%) finished the whole cycle (3 sets). A significant improvement was observed from the training set to the test set; the median κ score improved from 0.72 to 0.77 (P=.002).

Conclusions
e-Learning is an effective method to instruct pathologists and pathology residents for scoring the TSR. The reliability of scoring improved from the training to the test set and did not fall back with the repetition set, confirming the reproducibility of the TSR scoring method.

Trial Registration
The Netherlands Trial Registry NTR7270; https://www.trialregister.nl/trial/7072

International Registered Report Identifier (IRRID)
RR2-10.2196/13464
Comparing an eHealth Program (My Hip Journey) With Standard Care for Total Hip Arthroplasty: Randomized Controlled Trial
Authors: Saunders Rosemary , Seaman Karla , Emery Laura , Bulsara Max , Ashford Catherine , McDowall Judith , Gullick Karen , Ewens Beverley , Sullivan Trudy , Foskett Charlotte , Whitehead Lisa 
Published: March 2021

Background
The role of eHealth programs to support patients through surgical pathways, including total hip arthroplasty (THA), is rapidly growing and offers the potential to improve patient engagement, self-care, and outcomes.

Objective
The aim of this study is to compare the effects of an eHealth program (intervention) versus standard care for pre- and postoperative education on patient outcomes for primary THA.

Methods
A prospective parallel randomized controlled trial with two arms (standard care and standard care plus access to the eHealth education program) was conducted. Participants included those who underwent THA. Outcome measures were collected preadmission, at 6 weeks, and at 3 and 6 months after surgery. The primary outcome was the Hip Dysfunction and Osteoarthritis Outcome Score. Secondary outcomes were a 5-level 5-dimension quality of life measure and the self-efficacy for managing chronic disease scale. Demographic and clinical characteristics were also collected. A satisfaction survey was completed by all participants 6 weeks after surgery, and those in the intervention arm completed an additional survey specific to the eHealth program.

Results
A total of 99 patients were recruited: 50 in the eHealth program (intervention) and 49 in standard care (control). Clinical improvements were demonstrated in both groups across all time points. Per-protocol analysis demonstrated no differences between the groups for all outcome measures across all time points. Participants in the eHealth program reported that the program was accessible, that they felt comfortable using it, and that the information was helpful.

Conclusions
This study demonstrated that the eHealth program, in addition to standard care, had no additional benefit to THA recovery compared with standard care alone. The study found that the eHealth program was highly valued by participants, and it supported the preoperative preparation, recovery, and postoperative rehabilitation of participants.

Trial Registration
Australian New Zealand Clinical Trial Registry ACTRN12617001433392; http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=373657
Ionians and Carians in an Aramaic Letter from Saqqâra: Notes for a Tentative Interpretation of NSaqPap 26
Authors: Santini Marco 
Published: March 2021

This paper aims to present preliminary textual and historical observations towards a more comprehensive interpretation of a late 5th-4th cent. BC fragmentary letter of a Persian official from the corpus of Aramaic papyri of Saqqâra (NSaqPap 26). The understanding of this document, which deals with some situation of turbulence arisen between the Persian administration at Memphis/Saqqâra and the Ionians and Carians who lived and worked on the spot, is rendered complicated by the poor conditions of preservation of the papyrus, whose top and right portions are lost. Apart from the editio princeps by J.B. Segal (Aramaic Texts from North Saqqâra, London 1983, no. 26) and few additional notes in the reviews of it by J. Teixidor (JAOS1985) and S. Shaked (Orientalia1987), specific contributions on the piece are lacking. More in particular, despite its relevance to the study of the long-established communities of Greeks and Carians in Egypt, the letter has not received yet an adequate treatment from the historical point of view.

Following a lexical and syntactical revision, I provide a new tentative translation of the text, with the aim to reach as thorough and coherent an interpretation of the document as possible, and to shed further light on the living conditions of the communities of Ionians and Carians in Egypt under the Persian rule. By further contextualizing the events described in the letter with the aid of external sources, I argue for a mercenary revolt that affected the storehouses at the port of Memphis as the situation that prompted the response of the local Persian administration.
La science du climat au prisme de la culture : une typologie symbolico-éthique de la recherche en communication
Authors: Kane Oumar , Pilon Diabaté Alexia , Francioni Arnaud , Rawi Ahmed-Al , Bizimana Aimé-Jules 
Published: March 2021

Background:In recent decades, climate has become one of the most hotly contested issues in relation to the ecological crisis. It encompasses challenges of such magnitude that “climate change” on its own has almost come to constitute a multidisciplinary area of research where scholarly and popular discourses interact forcefully. Analysis:This article uses both symbolic-religious and ethical frameworks to describe a sample of scientific articles on climate change. It focuses on the Canadian context and favours a communicational perspective. Also, it symmetrically applies to scholarly discourse categories that are usually reserved for popular discourse. In doing so, it proposes an explanation of the ethical, symbolic and religious perspectives through which the works in our discipline address climate change. Conclusion and implication:This article’s originality lies in its analysis of how cultural categories influence communication about the environment. Through this approach, it highlights the connections between popular and scholarly discourses on climate.
Perancangan Aplikasi E-Discussion Pada SMA Negeri 1 Banuhampu
Authors: Mayati Sri , Supriadi Supriadi , Khomaruddin Agus Nur 
Published: March 2021

Penelitian yang penulis lakukan ini dilatar belakangi oleh, dimana saat ini teknologi sangat berpengaruh untuk penunjang proses pembelajaran, sebagian besar siswa sudah sudah memiliki <em>smarphone</em>, tetapi dipergunakan untuk bermain <em>game online</em> dan sosial media yang tidak mendukung pada proses pembelajaran. Keterbatasan ruang dan waktu dalam proses belajar mengajar di sekolah, Kebiasaan siswa belajar kebut satu malam membuat siswa takut mengadapi UN, biasanya peserta didik sangat membutuhkan pendampingan secra khusus, dorongan kebutuhan itu terjadi tidak menentu, tidak terjadwal. Cara mendeskripsikan pemanfaatan aplikasi diskusi secara<em> online</em> di rumah. Penelitian ini bertujuan untuk mengembangkan dan menghasilkan aplikasi <em>e-discussion</em>yang tervalidasi dan mendeskripsikan kevalidan, kepraktisan dan keefektifannya.<p>Penelitian ini merupakan <em>Research and Development</em> dengan lima tahapan (<em>ADDIE</em>) yaitu Analisis, Desain, Pengembangan, Implementasi dan Evaluasi. Pada tahap development model pengembangan <em>Waterfall</em> yang terdiri dari lima tahap yaitu, Definisi persyaratan, Perancangan sistem dan perangkat lunak, Implementasi dan pengujian unit, Integrasi dan pengujian sistem, Operasi dan pemeliharaan. Uji produk yang digunakan yaitu Uji Validitas, Uji Praktikalitas, Uji Efektifitas.</p><p>Hasil dari penelitian perancangan aplikasi <em>e-discussion</em> untuk digunakan digunakan oleh guru/admin dan siswa/<em>user </em>sebagai wadah/tempat untuk pemanfaatan ruang dan waktu. Sedangkan uji validitas dari 4 orang <em>expert </em>diperoleh nila 0,91 yang dinyatakan <strong>sangat v</strong><strong>alid </strong>(berdasar perhitungan validitaas dengan formula aiken’s)<strong>, </strong>sedangkan untuk uji praktikalitas dari 20 orang praktisi<em> </em>diperoleh nilai 91.2 yang dinyatakan <strong>sangat</strong> <strong>praktis</strong>, dan untuk uji efektifitas dari 21 orang siswa<em> </em>diperoleh nilai 0.95 kategori sangat tinggi yang dinyatakan <strong>sangat efektif</strong>.</p>
Optimalisasi Manajemen kinerja TI Perusahaan Perbankan Menggunakan BSC dan COBIT 4.1
Authors: Pawan Elvis , Soepriyanto Budi 
Published: March 2021

<p><em>Mengoptimalisasi kinerja TI untuk mendukung tercapainya visi dan misi perusahaan merupakan hal yang wajib dilakukan. Salah satu tujuan BPR PMM adalah memberikan pelayanan terbaik kepada nasabah, hal itu bukan sesuatu yang mudah tercapai tanpa bantuan TI. Untuk mengetahui peranan TI dalam sebuah perusahaan maka perlu dilakukan pengukuran secara bekelanjutan, penelitian ini bertujuan mengukur peranan TI pada BPR PMM apakah digunakan secara optimal atau belum.</em></p><p><em> Dalam penelitian ini mengukur peranan TI pada BPR PMM menggunakan framework BSC dan COBIT 4.1, metode ini baik dikombinasikan untuk mengukur tata kelola TI dalam sebuah perusahaan jika dibandingkan dengan beberapa metode lain seperti Peterson dan weill-Ross.</em></p><p><em>Penelitian ini menghasilkan sebuah hasil pengukuran tingkat kematangan penerapan TI dalam mendukung operasional pada BPR PMM, dari semua proses COBIT yang dinilai tingkat kematangan terendah pada proses PO2=2,733 dengan nilai gap 1,267, sedangkan nilai tertinggi pada proses PO8=3,790 dengan nilai gap =0,210. Secara umum tingkat kematangan penerapan TI pada BPR PMM berada pada level 3 dengan kategori defined sedangkan tingkat kematangan diharapkan berada pada level 4 dengan kategori manage and measurable.</em></p>