bluuebunny/crossref_metadata_2025_split huggingface dataset:
Both partners practicing orgasmic meditation report having a mystical-type experience: results using the Mystical Experience Questionnaire
Authors: Siegel Vivian , Emmert-Aronson Benjamin 
Published: July 2021

Background: Practitioners in a variety of spiritual/religious traditions have described “mystical experiences”, defined by a common set of qualities. The “Mystical Experience Questionnaire” (MEQ30) provides a validated and quantitative measure of mystical experience, and has been used successfully to demonstrate that the hallucinogenic substance psilocybin triggers a mystical-type experience. Orgasmic Meditation (OM) is a structured, partnered meditative practice involving manual stimulation of the clitoris. Although the partners in an OM have different roles (one is stroking, and the other is being stroked), both claim benefit from the practice. The aim of the current study is to use the MEQ30 to assess to what extent participants report mystical experiences during OM, and to what extent that experience is correlated between the partners. Methods: In Study 1, 780 participants completed the MEQ30 with a single powerful OM in mind. In Study 2, 56 pairs of participants (both partners) completed the MEQ30 after their next OM. If the respondent had a score ≥60% of the maximum possible score on each of the four subscales of the MEQ30, this was considered a “complete” mystical experience. Results: Respondents from Study 1 reported an MEQ total score of 3.35 (SD = 1.08), with 62% of respondents reporting a complete mystical experience. Respondents from Study 2 reported an MEQ total score of 3.21 (SD = 0.92), with 23% reporting a complete mystical experience. We found strong relationships between MEQ total score and role (i.e., stroker or strokee), interrater agreement within-group index (aWG) = 0.46, and an even stronger relationship between partners and MEQ total score, aWG=0.71. Conclusions: These findings suggest that OM can trigger a substantial mystical experience in both partners. Whether the brains of people who OM show similar activity changes to those having other mystical experiences awaits future study.
Soluble FMS-Like Tyrosine Kinase: Role in placenta accreta spectrum disorder
Authors: Lumbanraja Sarma , Yaznil M Rizki , Siahaan Andre M , Berry Eka Parda Bancin 
Published: July 2021

Background: Placenta accreta is a pregnancy condition where the placenta's blood vessels attach too deeply to the uterine wall. Incidence of placenta accreta is increasingly seen today as the rate of cesarean section increases, however, the exact pathophysiology of this condition is still not fully understood. Soluble fms-like tyrosine kinase-1 (sflt-1) as a protein produced by the placenta was found to be decreased in placenta accreta, Therefore we aim to see if sflt-1 has a role in the development of placenta accreta. Methods: This study involved 40 samples from patients that had been diagnosed with placenta accreta spectrum disorder (case group), and 40 samples from patients with normal pregnancies (control group) at Rumah Skit Umum Pusat H.Adam Malik (RSUP) Haji Adam Malik Medan, in Indonesia. Diagnosis of placenta accreta syndrome was based on Placenta Accreta Spectrum Score (PAS), and International Federation of Gynecology and Obstetrics (FIGO) classification of placenta accreta spectrum disorder.Analyses were performed by independent t-test, man Whitney U test, and Kruskal-Wallis analysis test, with a P-value <0.05 considered as statistically significant (95%CI). Results: Based on this study, we found that the sFlt-1 level in the case group was lower than the control group. Data analysis using the Kruskal-Wallis test showed that there was a difference in sFlt-1 levels in this study group (p = 0.02), which was further evaluated with post hoc analysis using Mann. Whitney U test. The results indicated that there were significant differences between the control and PAS 0, PAS1, and PAS 2 (p = 0.043; p = 0.002; p = 0.03). Conclusion: sFlt-1 levels decreased in placental invasive pregnancies compared to normal pregnancies, however, this still needs to be investigated further in a multi-center study, considering that sFlt-1 levels are also influenced by ethnicity and other conditions that cannot be excluded in this study.
Opioid epidemic and prescribing in hospice and palliative care: a review of the literature
Authors: Borders Joshua R , Letvak Susan , Amirehsani Karen A , Ross Ratchneewan , Phifer Nancy 
Published: July 2021

Background:Rising rates of opioid abuse worldwide have led to the implementation of policies to curb opioid prescribing. It is unknown what impact these policies have on prescribing within the setting of hospice and palliative care.Objectives:To determine the current state of the science of opioid prescribing in hospice and palliative care in relation to the opioid epidemic and associated policies.Methods:A systematic integrative literature review was conducted using the Cumulative Index of Nursing and Allied Health Literature (CINAHL), PubMed, ProQuest Central and SCOPUS.Results:Most of the existing literature examines physician perspectives related to opioid prescribing in primary care settings. Ample evidence exists that policies can and do affect rates of opioid prescribing in specialties outside of hospice and palliative care. There is limited evidence to suggest how these policies affect opioid prescribing in hospice and palliative care. However, the available evidence suggests that opioids are necessary in hospice and palliative care in order to manage pain.Conclusion:Further research is necessary to examine the possible negative impact of the opioid epidemic on opioid prescribing in hospice and palliative care.
High-absorption grating–insulator–metal structures
Authors: Chen Xu , He DongJian , Wu JiuHui 
Published: July 2021

A thin grating–insulator–metal (GIM) structure consisting of a top metal grating layer on a dielectric layer and a bottom metal layer is proposed, which shows a broadband high absorption at a small thickness. This phenomenon is attributed to the appropriate effective surface permittivity of the top grating layer and the cavity resonance of the middle insulator layer. By optimizing the structural and material parameters, the materials of the GIM structure from top to bottom are Mn,

A
l

2

O

3

, and Mn with thicknesses of 10, 70, and 70 nm, respectively. The structure with these optimum parameters is fabricated and characterized, and an improved performance with absorption exceeding 90% in the visible region is obtained using Mn as the metal layers. The experimental results are in good agreement with the numerical values, depicting an ultrabroad absorption bandwidth. The conclusions presented here could have potential applications in optical devices used for optical displacement detection and visible light absorption.
Miltefosine enhances infectivity of a miltefosine-resistant Leishmania infantum strain by attenuating its innate immune recognition
Authors: Bulté Dimitri , Van Bockstal Lieselotte , Dirkx Laura , Van den Kerkhof Magali , De Trez Carl , Timmermans Jean-Pierre , Hendrickx Sarah , Maes Louis , Caljon Guy 
Published: July 2021

BackgroundMiltefosine (MIL) is currently the only oral drug available to treat visceral leishmaniasis but its use as first-line monotherapy has been compromised by an increasing treatment failure. Despite the scarce number of resistant clinical isolates, MIL-resistance by mutations in a single aminophospholipid transporter gene can easily be selected in a laboratory environment. These mutations result in a reduced survival in the mammalian host, which can partially be restored by exposure to MIL, suggesting a kind of drug-dependency.Methodology/Principal findingsTo enable a combined study of the infection dynamics and underlying immunological events for differentialin vivosurvival, firefly luciferase (PpyRE9) / red fluorescent protein (DsRed) double-reporter strains were generated of MIL-resistant (MIL-R) and syngeneic MIL-sensitive (MIL-S)Leishmania infantum. Results in C57Bl/6 and BALB/c mice show that MIL-R parasites induce an increased innate immune response that is characterized by enhanced influx and infection of neutrophils, monocytes and dendritic cells in the liver and elevated serum IFN-γ levels, finally resulting in a less efficient establishment in liver macrophages. The elevated IFN-γ levels were shown to originate from an increased response of hepatic NK and NKT cells to the MIL-R parasites. In addition, we demonstrated that MIL could increase thein vivofitness of MIL-R parasites by lowering NK and NKT cell activation, leading to a reduced IFN-γ production.Conclusions/SignificanceDifferential induction of innate immune responses in the liver was found to underlie the attenuated phenotype of a MIL-R parasite and its peculiar feature of drug-dependency. The impact of MIL on hepatic NK and NKT activation and IFN-γ production following recognition of a MIL-R strain indicates that this mechanism may sustain infections with resistant parasites and contribute to treatment failure.
Efficacy and safety of palbociclib and ribociclib in patients with estrogen and/or progesterone receptor positive, HER2 receptor negative metastatic breast cancer in routine clinical practice
Authors: Rath Sushmita , Elamarthi Prahalad , Parab Pallavi , Gulia Seema , Nandhana Ravindra , Mokal Smruti , Kembhavi Yogesh , Perumal Prema , Bajpai Jyoti , Ghosh Jaya , Gupta Sudeep 
Published: July 2021

Background
There is scant data from India on efficacy and safety of palbociclib and ribociclib in routine clinical practice.

Methods
This retrospective, observational, single institution study included patients with estrogen and/or progesterone receptor positive and human epidermal growth factor receptor 2 (HER2) negative metastatic breast cancers, who received palbociclib or ribociclib with any partner endocrine therapy in any line of treatment between January 2016 and June 2019. Data were analyzed for progression-free survival (PFS), overall survival (OS) and toxicity.

Results
The study included 101 female patients with median age of 57 (IQR 48–62) years, of whom 80 (79.2%) were postmenopausal, 79 (78.2%) received palbociclib or ribociclib in second- or later-line treatment, 59 (58.4%) received fulvestrant and 41 (40.6%) received an aromatase inhibitor. In first-line treatment, at a median follow-up of 21.7 (0.5–41.9) months, median PFS and OS were 21.1 (95%CI 16.36-not estimable) months and not reached, respectively. In second- or later-line setting, at a median follow-up of 17.2 (0.5–43.7) months, median PFS and OS were 5.98 (95%CI 4.96–7.89) months and 20.2 (95%CI 14.1-not estimable) months, respectively. Grade 3–4 neutropenia and febrile neutropenia were seen in 45 (45.0%) and 9 (9.0%) patients, respectively while dose reduction was required in 32 (31.7%) patients. In multivariable Cox regression analysis, first-line setting (HR 0.49, 95%CI 0.25–0.97, p = 0.043) and ECOG performance status 1 (HR 0.43, 95%CI 0.20–0.91, p = 0.028) were significantly associated with PFS while only ECOG PS 1 was significantly associated (HR 0.04, 95%CI 0.008–0.206, p = 0.000) with OS.

Conclusion
Palbociclib and ribociclib, when used in routine clinical practice in first or subsequent lines of treatment, resulted in efficacy and toxicity outcomes in concordance with those expected from pivotal trials.
Design and psychometric evaluation of schools’ resilience tool in Emergencies and disasters: A mixed-method
Authors: Mirzaei Samaneh , Mohammadinia Leila , Nasiriani KHadijeh , Dehghani Tafti Abbas Ali , Rahaei Zohreh , Falahzade Hossein , Amiri Hamid Reza , Sharif Nia Hamid , Dehghani Mohammad Hossein 
Published: July 2021

Background
In addition to their educational role, resilient schools have a good capacity in response to disasters. Due to the large student population, the schools can be a safe and secure environment during disasters, in addition to maintaining their performance after. Given the role and importance of the schools, the impact of culture and environment on resilience, without any indigenous and comprehensive tool for measuring the resilience in Iran, the study aimed to design and psychometrically evaluate the measurement tools.

Method
This study was conducted using a mixed-method sequential explanatory approach. The research was conducted in two main phases of production on items based on hybrid model and the psychometric evaluation of the tool. The second phase included validity (formal, content and construction) and reliability (multiplex internal similarity, consistency and reliability).

Result
The integration of systematic and qualitative steps resulted in entering 91 items into the pool of items. After formal and content validity, 73 items remained and 44 were omitted in exploratory factor analysis. A questionnaire with 5 factors explained 52.08% of total variance. Finally, after the confirmatory factor analysis, the questionnaire was extracted with 29 questions and 5 factors including "functional", "architectural", "equipment", "education" and "safety". Internal similarity and stability in all factors were evaluated as good.

Conclusion
The result showed that the 29-item questionnaire of school resilience in emergencies and disasters is valid and reliable, that can be used to evaluate school resilience. On the other hand, the questionnaire on assessment of school resilience in disasters enables intervention to improve its capacity.
Effects of riverbank erosion on mental health of the affected people in Bangladesh
Authors: Hossain Altaf , Alam Md. Jahangir , Haque Md. Rezaul 
Published: July 2021

Background
In Bangladesh, riverbank erosion is a major problem that regularly displaces millions of people and affects their mental health every year.

Objectives
The primary objective is to explore the effects of riverbank erosion on mental health problems such as depression, anxiety, and stress in Bangladesh.

Methods
We conducted a household survey from August 2019 to November 2019 on randomly selected adult respondents from Rajbari District located along the Ganges River and Tangail District located along the Brahmaputra River. The respondents were divided into two groups: exposed and non-exposed to riverbank erosion. All participants were asked to complete self-reported questionnaires on the Depression, Anxiety and Stress Scale-21, and other socio-demographic, economic and riverbanks erosion-related factors. We performed Chi-squared test and multiple logistic regression analysis to explore the significant risk factors (P<0.05) of mental illness (depression, anxiety and stress).

Results
We surveyed 611 households, of whom 410 were from Rajbari and 201 were from Tangail. Among 611 respondents, 509 (83.31%) were exposed by riverbank erosion whereas 102 (16.69%) were non-exposed. The prevalence of depression, anxiety and stress (DAS) was 38.30%, 76.60%, 32.41%, respectively, and they were significantly higher among the exposed group than the non-exposed group (depression: 45.19% versus 3.92%, P<0.001; anxiety: 82.71% versus 46.08%, P<0.001; stress: 38.11% versus 3.92%, P<0.001). The respondents exposed to river erosion were respectively 8.28, 2.26 and 5.09 times more likely to develop DAS disorder compared to their non-exposed counterparts (ORD = 8.28, 95% CI = 2.75–24.89; ORA = 2.26, 95% CI = 1.31–3.88; ORS = 5.09, 95% CI = 1.64–15.76). Females and those who lost their houses and displaced, were more likely to have DAS disorder compared to their respective counterparts.

Conclusions
The exposed people were more likely to experience mental health problem and demand some social safety net programs with special focus on female and those who lost houses and displaced.
Peer video feedback builds basic life support skills: A randomized controlled non-inferiority trial
Authors: Sopka Saša , Hahn Fabian , Vogt Lina , Pears Kim Hannah , Rossaint Rolf , Rudolph Jenny , Klasen Martin 
Published: July 2021

Introduction
Training Basic Life Support saves lives. However, current BLS training approaches are time-consuming and costly. Alternative cost-efficient and effective training methods are highly needed. The present study evaluated whether a video-feedback supported peer-guided Basic Life Support training approach achieves similar practical performance as a standard instructor-guided training in laypersons.

Methods
In a randomized controlled non-inferiority trial, 288 first-year medical students were randomized to two study arms with different Basic Life Support training methods: 1) Standard Instructor Feedback (SIF) or 2) a Peer Video Feedback (PVF). Outcome parameters were objective data for Basic Life Support performance (compression depth and rate) from a resuscitation manikin with recording software as well as overall Basic Life Support performance and subjective confidence. Non-inferiority margins (Δ) for these outcome parameters and sample size calculation were based on previous studies with Standard Instructor Feedback. Two-sided 95% confidence intervals were employed to determine significance of non-inferiority.

Results
Results confirmed non-inferiority of Peer Video Feedback to Standard Instructor Feedback for compression depth (proportion difference PVF–SIF = 2.9%; 95% CI: -8.2% to 14.1%; Δ = -19%), overall Basic Life Support performance (proportion difference PVF–SIF = 6.7%; 95% CI: 0.0% to 14.3%; Δ = -27%) and subjective confidence for CPR performance (proportion difference PVF–SIF = -0.01; 95% CI: -0.18–0.17; Δ = -0.5) and emergency situations (proportion difference PVF–SIF = -0.02; 95% CI: -0.21–0.18; Δ = -0.5). Results for compression rate were inconclusive.

Discussion
Peer Video Feedback achieves comparable results as standard instructor-based training methods. It is an easy-to-apply and cost-efficient alternative to standard Basic Life Support training methods. To improve performance with respect to compression rate, additional implementation of a metronome is recommended.
INVESTIGATION NON-ALKALOIDAL BIOLOGICAL ACTIVE COMPOUNDS OF DATURA INNOXIA
Authors: Garaev Eldar Abdulla , Valiyeva Adila Karam , Karamli Amalia Nazim , Huseynova Nigar Mustafa 
Published: July 2021

The purpose of the investigation is to study non-alkaloidal biological active compounds of various organs, the antimicrobial activity of plant oil and ethanolic extracts of Datura innoxia Mill. from nightshades (Solanaceae). D. innoxia grows in the natural environmental conditions of the Republic of Azerbaijan. We have studied presence of several biological active compounds – triterpenoic acids, essential oils, fatty acids, sterols and amino acids in the content of various organs of plant. Oil was obtained by using Soxhlet apparatus and investigated by GC method. After removing the oil from the seeds, triterpenoic acids - oleanolic and ursolic acids were isolated and identified by TLC. Essential oils were obtained from plant leaves by hydrodistillation and studied by GC-MS method. 20 amino acids were identified in the aerial part of the plant by the HPLC method, with amino acid analyzer L-8800 (Hitachi, Ltd.), 12 of them are non-essential, 8 are essential.
The antimicrobial activity of plant oils of seed and ethanolic extracts of some parts (roots, stems, leaves, flowers, fruits and seeds) were studied on Staphylococcus aureus, Esherichia coli, Pseudomonas aeruginosa, Bacillus anthracoides, Klebsiella pneumoniae and Candida albicans. The significant activity of some extracts (stems, leaves, fruits and seeds) was observed against S. aureus, E. coli, C. albicans, B. anthracoides and plant oil against C. albicans.
Estimación de los límites de cambio (deltacheck) en el laboratorio clínico
Authors: Castro-Castro Maria-José , Sánchez-Navarro Lourdes 
Published: July 2021

Resumen

Objetivos
Los límites de cambio, conocidos como deltacheck, son aquellos valores que indican sospecha de que la variación entre el resultado actual obtenido y el resultado anterior de la misma magnitud en un mismo paciente se debe a un error y, por tanto, dicho resultado ha de ser cuestionado. El propósito del presente estudio es establecer los límites de cambio para algunas magnitudes hematológicas y bioquímicas, con el fin de detectar resultados potencialmente erróneos, así como evaluar su eficacia a la hora de detectar resultados erróneos, para estandarizar el proceso de control de la plausibilidad.

Métodos
Se calcularon los límites de cambio para 13 magnitudes bioquímicas y 6 hematológicas. Para cada magnitud, se calcularon las diferencias relativas (D), expresadas como la diferencia porcentual entre dos resultados consecutivos en el mismo paciente. A partir de dichas diferencias (D), se calcularon los percentiles 5 y 95 de la distribución de datos.
Para evaluar eficacia de los límites de cambio se emplearon 43 informes de laboratorio considerados erróneos a partir del procedimiento habitual de control de la plausibilidad utilizado en el laboratorio.

Resultados
De los 43 informes de laboratorio que contenían algún error, 31 (72%) fueron clasificados como errores de contaminación por administración endovenosa y 12 (28%) como errores en la identificación del paciente. Todos los informes de laboratorio erróneos fueron detectados al aplicar conjuntamente los límites de cambio estimados de las diferentes magnitudes.

Conclusiones
La mejor combinación de magnitudes en la misma muestra capaces de detectar informes de laboratorio erróneos fue: concentración de potasio, albúmina, creatinina, glucosa y hemoglobina.
Combined mixed finite element and nonconforming finite volume methods for flow and transport in porous media
Authors: El Moutea Omar , El Amri Hassan 
Published: July 2021

Abstract
This paper is concerned with numerical methods for a coupled system of two partial differential equations (PDEs), modeling flow and transport of a contaminant in porous media.
This coupled system, arising in modeling of flow and transport in heterogeneous porous media, includes two types of equations: an elliptic and a diffusion-convection equation.
We focus on miscible flow in heterogeneous porous media.
We use the mixed finite element method for the Darcy flow equation over triangles, and for the concentration equation, we use nonconforming finite volume methods in unstructured mesh.
Finally, we show the existence and uniqueness of a solution of this coupled scheme and demonstrate the effectiveness of the methodology by a series of numerical examples.