bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive analysis of the ceRNA network in coronary artery disease
Authors: Bian Weikang , Jiang Xiao-Xin , Wang Zhicheng , Zhu Yan-Rong , Zhang Hongsong , Li Xiaobo , Liu Zhizhong , Xiong Jing , Zhang Dai-Min 
Published: December 2021

AbstractWith the rapid aging of the population, coronary artery disease (CAD) has become one of the most fatal chronic diseases. However, the genetic mechanism of CAD is still unclear. The purpose of this study is to construct the lncRNA-miRNA-mRNA regulatory network for CAD diseases and systematically identify differentially expressed genes in patients with coronary heart disease. In this study, two lncRNA datasets (GSE69587 and GSE113079) and a microRNA dataset (GSE105449) which contained 393 and 38 CAD samples were selected. In addition, two mRNA datasets which named GSE113079 (98 CAD samples) and GSE9820 (8 CAD samples) were selected to search the differentially expressed genes (DEGs). By comparing the expression data between CAD and control samples, a total of 1111 lncRNAs, 2595 mRNAs and 22 miRNAs were identified. Based on the DEGs, a lncRNA-miRNA-mRNA ceRNA network was constructed to explore the hub nodes in CAD. In the ceRNA network, the lncRNAs KCNQ1OT1 and H19 showed high connectivity with the nine miRNAs. GO and KEGG results showed that genes in ceRNA networks were mainly involved in nitrogen compound metabolic process, PI3K-Akt signaling pathway and retrograde endocannabinoid signaling. These findings will improve the understanding of the occurrence and development mechanism of CAD.
A novel ex vivo model for critical illness neuromyopathy using freshly resected human colon smooth muscle
Authors: Patejdl Robert , Klawitter Felix , Walter Uwe , Zanaty Karim , Schwandner Frank , Sellmann Tina , Porath Katrin , Ehler Johannes 
Published: December 2021

AbstractPatients suffering from critical illness are at risk to develop critical illness neuromyopathy (CINM). The underlying pathophysiology is complex and controversial. A central question is whether soluble serum factors are involved in the pathogenesis of CINM. In this study, smooth muscle preparations obtained from the colon of patients undergoing elective surgery were used to investigate the effects of serum from critically ill patients. At the time of blood draw, CINM was assessed by clinical rating and electrophysiology. Muscle strips were incubated with serum of healthy controls or patients in organ baths and isometric force was measured. Fifteen samples from healthy controls and 98 from patients were studied. Ratios of responses to electric field stimulation (EFS) before and after incubation were 118% for serum from controls and 51% and 62% with serum from critically ill patients obtained at day 3 and 10 of critical illness, respectively (p = 0.003, One-Way-ANOVA). Responses to carbachol and high-K+ were equal between these groups. Ratios of post/pre-EFS responses correlated with less severe CINM. These results support the existence of pathogenic, i.e. neurotoxic factors in the serum of critically ill patients. Using human colon smooth muscle as a bioassay may facilitate their future molecular identification.
Spatiotemporal distribution of human brucellosis in Inner Mongolia, China, in 2010–2015, and influencing factors
Authors: Liang Danyan , Liu Dan , Yang Min , Wang Xuemei , Li Yunpeng , Guo Weidong , Du Maolin , Wang Wenrui , Xue Mingming , Wu Jing , Cui Buyun , Yin Shaohua , Wang Ruiqi , Li Shiyuan 
Published: December 2021

AbstractHuman brucellosis is caused by Brucella species and remains a major burden in both human and domesticated animal populations, especially in Inner Mongolia, China. The aims of this study were to analyze the spatiotemporal trends in human brucellosis in Inner Mongolia during 2010 to 2015, to explore the factors affecting the incidence of brucellosis. The results showed that the annual incidence was 29.68–77.67 per 100,000, and peaked from March to June. The majority of human brucellosis was male farmers and herdsmen, aged 40–59 years. The high-risk areas were mainly Xilin Gol League and Hulunbeier City. The incidence of human brucellosis in Inner Mongolia decreased during 2010 to 2015, although the middle and eastern regions were still high-risk areas. The regions with larger number of sheep and cattle, lower GDP per capita, less number of hospital beds, higher wind speed, lower mean temperature more likely to become high-risk areas of human brucellosis.
Extractable quantum work from a two-mode Gaussian state in a noisy channel
Authors: Cuzminschi Marina , Zubarev Alexei , Isar Aurelian 
Published: December 2021

AbstractWe study a Szilard engine based on a Gaussian state of a system consisting of two bosonic modes placed in a noisy channel. As the initial state of the system is taken an entangled squeezed thermal state, and the quantum work is extracted by performing a measurement on one of the two modes. We use the Markovian Kossakowski-Lindblad master equation for describing the time evolution of the open system and the quantum work definition based on the second order Rényi entropy to simulate the engine. We also study the information-work efficiency of the Szilard engine as a function of the system parameters. The efficiency is defined as the ratio of the extractable work averaged over the measurement angle and the erasure work, which is proportional to the information stored in the system. We show that the extractable quantum work increases with the temperature of the reservoir and the squeezing between the modes, average numbers of thermal photons and frequencies of the modes. The work increases also with the strength of the measurement, attaining the maximal values in the case of a heterodyne detection. The extractable work is decreasing by increasing the squeezing parameter of the noisy channel and it oscillates with the phase of the squeezed thermal reservoir. The efficiency mostly has a similar behavior with the extractable quantum work evolution. However information-work efficiency decreases with temperature, while the quantity of the extractable work increases.
Reconfigurable single-material Peltier effect using magnetic-phase junctions
Authors: Nakagawa Kurea , Yokouchi Tomoyuki , Shiomi Yuki 
Published: December 2021

AbstractPeltier effects, which produce a heat flux at the junction of two different materials, have been an important technology for heating and cooling by electrical means. Whereas Peltier devices have advantages such as cleanliness, silence, compactness, flexibility, reliability, and efficiency, relatively complicated modular structures are unavoidable, leading to a higher cost than that of commonly used refrigeration technology. Here, we provide a concept of a Peltier device composed of a single magnetic material exhibiting a first-order magnetic transition. Our concept is based on a controllable junction structure consisting of two magnetic phases with opposite Peltier coefficients instead of a semiconductor junction. Using $${\mathrm{Mn}}_{1.96}{\mathrm{Cr}}_{0.04}\mathrm{Sb}$$

Mn

1.96

Cr

0.04

Sb

samples with the first-order magnetic transition between ferrimagnetic (FI) and antiferromagnetic (AF) states, we successfully made a stable junction structure of AF/FI/AF by a pulse heating method and achieved a maximum Peltier coefficient of 0.58 mV. Our device concept was further verified by a numerical simulation based on a finite element method. The single-material Peltier effect reported here avoids a complex device design involving material junctions and is importantly reconfigurable.
Prognostic impact of polypharmacy by drug essentiality in patients on hemodialysis
Authors: Kitamura Mineaki , Yamaguchi Kosei , Ota Yuki , Notomi Satoko , Komine Maya , Etoh Rika , Harada Takashi , Funakoshi Satoshi , Mukae Hiroshi , Nishino Tomoya 
Published: December 2021

AbstractAlthough polypharmacy is common among patients on hemodialysis (HD), its association with prognosis remains unclear. This study aimed to elucidate the association between the number of prescribed medicines and all-cause mortality in patients on HD, accounting for essential medicines (i.e., antihypertensives, antidiabetic medicines, and statins) and non-essential medicines. We evaluated 339 patients who underwent maintenance HD at Nagasaki Renal Center between July 2011 and June 2012 and followed up until June 2021. After adjusting for patient characteristics, the number of regularly prescribed medicines (10.0 ± 4.0) was not correlated with prognosis (hazard ratio [HR]: 1.01, 95% confidence interval [CI] 0.97–1.05, p = 0.60). However, the number of non-essential medicines (7.9 ± 3.6) was correlated with prognosis (HR: 1.06, 95% CI 1.01–1.10, p = 0.009). Adjusting for patient characteristics, patients who were prescribed more than 10 non-essential medicines were found to have a significantly higher probability of mortality than those prescribed less than five non-essential medicines, with a relative risk of 2.01 (p = 0.004). In conclusion, polypharmacy of non-essential medicines increases the risk of all-cause mortality in patients on HD. As such, prescribing essential medicines should be prioritized, and the clinical relevance of each medicine should be reviewed by physicians and pharmacists.
A new circulating accumulation emission model for assessing dust emission from open pit mine
Authors: Tang Wanjun , Li Fengming 
Published: December 2021

AbstractTo reduce the inaccuracy of using the monitoring data outside the pit to evaluate the unorganized emission dust source of open pit mine, the circulating accumulation emission model is established. Based on the model, the monitoring data in the pit can be converted into the dust emission from the pit. The main conclusions include: (1) the circulating accumulation emission model is suitable for the dust diffusion process in open pit mine. The ratio of diffusion $$\mu$$
μ
and the ratio of surplus $$\varepsilon$$
ε
were used to simulate the dust diffusion process in open pit mine, containing emission, retention and diffusion. (2) The initial value of the dust in the pit before the team operation has little influence on the final stable value. (3) When the external dust enters the pit, it will accumulate under the action of eddy current. The dust background value in the pit is different from that outside the pit. (4) The dust emission from the pit can be calculated from the monitoring data in the pit based on the circulating accumulation emission model. The model can deal with environmental changes such as the wind direction and speed, without arranging a lot of external monitoring equipment like the traditional external monitoring methods.
Commercial microbiota test revealed differences in the composition of intestinal microorganisms between children with autism spectrum disorders and neurotypical peers
Authors: Jendraszak Magdalena , Gałęcka Mirosława , Kotwicka Małgorzata , Regdos Aleksandra , Pazgrat-Patan Michalina , Andrusiewicz Mirosław 
Published: December 2021

AbstractThe early-life modifications of intestinal microbiota may impact children's subsequent emotional and cognitive development. Studies show that some bacteria species in gut microbiota, and the lack of others, may play a key role in autism spectrum disorders (ASD) development. Fecal samples were obtained from three groups of children: 16 healthy, 24 with allergies (ALG), and 33 with ASD (probiotics and non-probiotics users). The analysis was carried out according to the KyberKompakt Pro protocol. We observed a significantly higher level of Klebsiella spp. in the healthy children from the non-probiotics group, considering three groups. In the same group, Bifidobacterium spp. the level was lower in ASD compared to neurotypical individuals. In healthy children who did not use probiotics, strong positive correlations were observed in E. coli and Enterococcus spp. and Bacteroides and Klebsiella spp., and a negative correlation for Akkermansia muciniphila with both Klebsiella spp. and Bacteroides spp. In the ASD group who take probiotics, a strongly negative correlation was observed in Lactobacillus spp., and both Faecalibacterium prausnitzii and Akkermansia muciniphila levels. In the ALG group, the strongest, negative correlation was found between Enterococcus spp. and Lactobacillus spp. as in Akkermansia muciniphila and Bifidobacterium spp. The simple commercial test revealed minor differences in the composition of intestinal microorganisms between children with autism spectrum disorders and neurotypical peers.
Synergistic effects of crop residue and microbial inoculant on soil properties and soil disease resistance in a Chinese Mollisol
Authors: Liu Haolang , Qi Yuqi , Wang Jihong , Jiang Yan , Geng Mingxin 
Published: December 2021

AbstractThe soil-borne disease caused by Fusarium graminearum seriously affects the corn quality. Straw can greatly improve soil quality, but the effect is limited by its nature and environmental factors. This study explored the impact of straw-JF-1(biocontrol bacteria) combination on soil environment and soil disease resistance. The results showed that the combined treatment increased the proportion of soil large and small macro-aggregates by 22.50 and 3.84%, with soil organic carbon (SOC) content by 16.18 and 16.95%, respectively. Compared to treatment with returning straw to the field alone, the straw-JF-1 combination increased the soil content of humic acid, fulvic acid, and humin by 14.06, 5.50, and 4.37%, respectively. Moreover, A metagenomics showed that returning straw to the field alone increased the abundance of disease-causing fungi (Fusarium and Plectosphaerella), however, the straw-JF-1 combination significantly suppressed this phenomenon as well as improved the abundance of probiotic microorganisms such as Sphingomonas, Mortierella, Bacillus, and Pseudomonas. Functional analysis indicated that the combination of straw and JF-1 improved some bacterial functions, including inorganic ion transport and metabolism, post-translational modification/protein turnover/chaperones and function unknown, fungal functions associated with plant and animal pathogens were effectively inhibited. Pot experiments showed that the straw-JF-1 combination effectively inhibited the Fusarium graminearum induced damage to maize seedlings. Therefore, the combination of straw and JF-1 could be a practical method for soil management.
Clinical response to nivolumab in an INI1-deficient pediatric chordoma correlates with immunogenic recognition of brachyury
Authors: Williamson Laura M. , Rive Craig M. , Di Francesco Daniela , Titmuss Emma , Chun Hye-Jung E. , Brown Scott D. , Milne Katy , Pleasance Erin , Lee Anna F. , Yip Stephen , Rosenbaum Daniel G. , Hasselblatt Martin , Johann Pascal D. , Kool Marcel , Harvey Melissa , Dix David , Renouf Daniel J. , Holt Robert A. , Nelson Brad H. , Hirst Martin , Jones Steven J. M. , Laskin Janessa , Rassekh Shahrad R. , Deyell Rebecca J. , Marra Marco A. 
Published: December 2021

AbstractPoorly differentiated chordoma (PDC) is a recently recognized subtype of chordoma characterized by expression of the embryonic transcription factor, brachyury, and loss of INI1. PDC primarily affects children and is associated with a poor prognosis and limited treatment options. Here we describe the molecular and immune tumour microenvironment profiles of two paediatric PDCs produced using whole-genome, transcriptome and whole-genome bisulfite sequencing (WGBS) and multiplex immunohistochemistry. Our analyses revealed the presence of tumour-associated immune cells, including CD8+ T cells, and expression of the immune checkpoint protein, PD-L1, in both patient samples. Molecular profiling provided the rationale for immune checkpoint inhibitor (ICI) therapy, which resulted in a clinical and radiographic response. A dominant T cell receptor (TCR) clone specific for a brachyury peptide–MHC complex was identified from bulk RNA sequencing, suggesting that targeting of the brachyury tumour antigen by tumour-associated T cells may underlie this clinical response to ICI. Correlative analysis with rhabdoid tumours, another INI1-deficient paediatric malignancy, suggests that a subset of tumours may share common immune phenotypes, indicating the potential for a therapeutically targetable subgroup of challenging paediatric cancers.
Smartphone-based digital phenotyping for dry eye toward P4 medicine: a crowdsourced cross-sectional study
Authors: Inomata Takenori , Nakamura Masahiro , Sung Jaemyoung , Midorikawa-Inomata Akie , Iwagami Masao , Fujio Kenta , Akasaki Yasutsugu , Okumura Yuichi , Fujimoto Keiichi , Eguchi Atsuko , Miura Maria , Nagino Ken , Shokirova Hurramhon , Zhu Jun , Kuwahara Mizu , Hirosawa Kunihiko , Dana Reza , Murakami Akira 
Published: December 2021

AbstractMultidimensional integrative data analysis of digital phenotyping is crucial for elucidating the pathologies of multifactorial and heterogeneous diseases, such as the dry eye (DE). This crowdsourced cross-sectional study explored a novel smartphone-based digital phenotyping strategy to stratify and visualize the heterogenous DE symptoms into distinct subgroups. Multidimensional integrative data were collected from 3,593 participants between November 2016 and September 2019. Dimension reduction via Uniform Manifold Approximation and Projection stratified the collected data into seven clusters of symptomatic DE. Symptom profiles and risk factors in each cluster were identified by hierarchical heatmaps and multivariate logistic regressions. Stratified DE subgroups were visualized by chord diagrams, co-occurrence networks, and Circos plot analyses to improve interpretability. Maximum blink interval was reduced in clusters 1, 2, and 5 compared to non-symptomatic DE. Clusters 1 and 5 had severe DE symptoms. A data-driven multidimensional analysis with digital phenotyping may establish predictive, preventive, personalized, and participatory medicine.
Broadening the reach of the FDA Sentinel system: A roadmap for integrating electronic health record data in a causal analysis framework
Authors: Desai Rishi J. , Matheny Michael E. , Johnson Kevin , Marsolo Keith , Curtis Lesley H. , Nelson Jennifer C. , Heagerty Patrick J. , Maro Judith , Brown Jeffery , Toh Sengwee , Nguyen Michael , Ball Robert , Dal Pan Gerald , Wang Shirley V. , Gagne Joshua J. , Schneeweiss Sebastian 
Published: December 2021

AbstractThe Sentinel System is a major component of the United States Food and Drug Administration’s (FDA) approach to active medical product safety surveillance. While Sentinel has historically relied on large quantities of health insurance claims data, leveraging longitudinal electronic health records (EHRs) that contain more detailed clinical information, as structured and unstructured features, may address some of the current gaps in capabilities. We identify key challenges when using EHR data to investigate medical product safety in a scalable and accelerated way, outline potential solutions, and describe the Sentinel Innovation Center’s initiatives to put solutions into practice by expanding and strengthening the existing system with a query-ready, large-scale data infrastructure of linked EHR and claims data. We describe our initiatives in four strategic priority areas: (1) data infrastructure, (2) feature engineering, (3) causal inference, and (4) detection analytics, with the goal of incorporating emerging data science innovations to maximize the utility of EHR data for medical product safety surveillance.
White matter disconnectivity fingerprints causally linked to dissociated forms of alexia
Authors: Ng Sam , Moritz-Gasser Sylvie , Lemaitre Anne-Laure , Duffau Hugues , Herbet Guillaume 
Published: December 2021

AbstractFor over 150 years, the study of patients with acquired alexia has fueled research aimed at disentangling the neural system critical for reading. An unreached goal, however, relates to the determination of the fiber pathways that root the different visual and linguistic processes needed for accurate word reading. In a unique series of neurosurgical patients with a tumor close to the visual word form area, we combine direct electrostimulation and population-based streamline tractography to map the disconnectivity fingerprints characterizing dissociated forms of alexia. Comprehensive analyses of disconnectivity matrices establish similarities and dissimilarities in the disconnection patterns associated with pure, phonological and lexical-semantic alexia. While disconnections of the inferior longitudinal and posterior arcuate fasciculi are common to all alexia subtypes, disconnections of the long arcuate and vertical occipital fasciculi are specific to phonological and pure alexia, respectively. These findings provide a strong anatomical background for cognitive and neurocomputational models of reading.
Observation of higher-order exceptional points in a non-local acoustic metagrating
Authors: Fang Xinsheng , Gerard Nikhil J R K , Zhou Zhiling , Ding Hua , Wang Nengyin , Jia Bin , Deng Yuanchen , Wang Xu , Jing Yun , Li Yong 
Published: December 2021

AbstractHigher-order exceptional points have attracted increased attention in recent years due to their enhanced sensitivity and distinct topological features. Here, we show that non-local acoustic metagratings enabling precise and simultaneous control over their multiple orders of diffraction can serve as a robust platform for investigating higher-order exceptional points in free space. The proposed metagratings, not only could advance the fundamental research of arbitrary order exceptional points, but could also empower unconventional free-space wave manipulation for applications related to sensing and extremely asymmetrical wave control.
Fishing in the city for food—a paradigmatic case of sustainability in urban blue space
Authors: Joosse Sofie , Hensle Lara , Boonstra Wiebren J. , Ponzelar Charlotte , Olsson Jens 
Published: December 2021

AbstractThis article presents fishing in the city for food (FCF) as a trenchant example of urban ecology, and the ways in which urban dwellers use, interact with, and depend on urban blue spaces. Our literature review demonstrates how FCF is studied in a diverse body of scientific publications that rarely draw on each other. As such, FCF and its relevance for sustainable and just planning of urban blue space remain relatively unknown. Using the literature review, a survey of FCF in European capitals, and examples from FCF in Stockholm, we demonstrate how attention to FCF raises pertinent and interrelated questions about access to water, food and recreation; human health; animal welfare and aquatic urban biodiversity.