bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allostery in Proteins as Point-to-Point Telecommunication in a Network: Frequency Decomposed Signal-to-Noise Ratio and Channel Capacity Analysis
Authors: Varolgüneş Yasemin Bozkurt , Rudzinski Joseph F. , Demir Alper 
Published: February 2021

AbstractAllostery in proteins is a phenomenon in which the binding of a ligand induces alterations in the activity of remote functional sites. This can be conceptually viewed aspoint-to-point telecommunication in a networked communication medium, where a signal (ligand) arriving at the input (binding site) propagates through the network (interconnected and interacting atoms) to reach the output (remote functional site). The reliable transmission of the signal to distal points occurs despite all the disturbances (noise) affecting the protein. Based on this point of view, we propose a computational frequency-domain framework to characterize the displacements and the fluctuations in a region within the protein, originating from the ligand excitation at the binding site and noise, respectively. We characterize the displacements in the presence of the ligand, and the fluctuations in its absence. In the former case, the effect of the ligand is modeled as an external dynamic oscillatory force excitation, whereas in the latter, the sole source of fluctuations is the noise arising from the interactions with the surrounding medium that is further shaped by the internal protein network dynamics. We introduce the excitation frequency as a key factor in aSignal-to-Noise ratio (SNR)based analysis, where SNR is defined as the ratio of the displacements stemming from only the ligand to the fluctuations due to noise alone. We then employ an information-theoretic (communication) channel capacity analysis that extends the SNR based characterization by providing a route for discovering new allosteric regions. We demonstrate the potential utility of the proposed methods for the representative PDZ3 protein.
The sequential and cooperative action of CSB, CSA and UVSSA targets the TFIIH
complex to DNA damage-stalled RNA polymerase II
Authors: van der Weegen Yana , Berman Hadar Golan , Mevissen Tycho E.T. , Apelt Katja , González-Prieto Román , Heilbrun Elisheva , Vertegaal Alfred C.O. , van den Heuvel Diana , Walter Johannes C. , Adar Sheera , Luijsterburg Martijn S. 
Published: February 2021

Summary
The response to DNA damage-stalled RNA polymerase II (RNAPIIo) involves the
assembly of the transcription-coupled repair (TCR) complex on actively
transcribed strands. The function of the TCR proteins CSB, CSA and UVSSA and the
manner in which the core DNA repair complex, including transcription factor IIH
(TFIIH), is recruited are largely unknown. Here, we define the assembly
mechanism of the TCR complex in human isogenic knockout cells. We show that TCR
is initiated by RNAPIIo-bound CSB, which recruits CSA through a newly identified
CSA-interaction motif (CIM). Once recruited, CSA facilitates the association of
UVSSA with stalled RNAPIIo. Importantly, we find that UVSSA is the key factor
that recruits the TFIIH complex in a manner that is stimulated by CSB and CSA.
Together these findings reveal a sequential and highly cooperative assembly
mechanism of TCR proteins and reveal the mechanism for TFIIH recruitment to DNA
damage-stalled RNAPIIo to initiate repair.
COVID-19 as a super crisis: implications for place management
Authors: Wexler Mark N. , Oberlander Judy 
Published: February 2021

Purpose
The purpose of this paper is to investigate COVID-19 as a super crisis in the design and management of places.

Design/methodology/approach
This theory-driven work outlines why and how, by treating COVID-19 as a super crisis, the immunological view rises in priority and swiftly ushers in short- and long-term implications for space design and place management.

Findings
First, this paper looks at the short-term impact of COVID-19 upon space and place management in addressing how porous bubbling, stippling and flexible curtaining respond to immediate retrofitting needs during the pandemic. Using the concept of COVID-19-induced collective trauma, this paper draws attention to health-care facilities, schools, workplaces, commercial buildings and public outdoor spaces. These sites require short-term improvisation in place and space design and will, where the collective trauma of COVID-19 leaves strong traces, require long-term redesign and rethinking.

Social implications
As a super crisis, COVID-19 generates contradictions in the existing trend in space and place studies from the notion of space and place as a container to one focusing on “flow.” A focus on flow highlights a focus on space and place as adaptable to changes in flow, especially as augmented and mediated by technology.

Originality/value
This treatment of COVID-19 as a super crisis is intended to stimulate the design and management of spaces and places in the post-COVID-19 period.
Study on coordination of industrial technology ambidextrous innovation in knowledge ecology spiral
Authors: Long Yue , Liu Pan 
Published: February 2021

Purpose
Knowledge input development and innovation implementation are new features of industrial technology innovation. The purpose of this study is to find the process of coordination and ecological spiral in the ambidextrous innovation of industrial technology.

Design/methodology/approach
To design the model of industrial technology ambidextrous innovation based on knowledge ecology spiral, an input-output model of knowledge for ambidextrous innovation and a spiral model of knowledge ecology were constructed based on an improved Lotka-Volterra model. Then, the equilibriums in different knowledge inputs and the spiral evolution of knowledge ecology were analyzed. Finally, the ambidextrous coordination mechanism of the core organization was revealed.

Findings
By coordinating the knowledge inputs and the knowledge ecology spiral, enterprises extend the R&D investments in the innovation chain, which will facilitate the knowledge inputs of the exploitative and exploratory innovation. Implementing the ambidextrous coordination in the technology innovation chain and the knowledge ecology chain has the advantage of promoting knowledge inputs, mobility and ecological spiral. Meanwhile, it can achieve the “multi-source, integration and coordination” development of industrial technology innovation.

Originality/value
The two-element innovative knowledge input coordination model and the knowledge ecological spiral model based on the improved Lotka-Volterra model are constructed, which extends the modeling way of the traditional knowledge input-output profit model. It is expected to reduce the amount of knowledge input of a single member and provide theoretical reference for improving the efficiency of knowledge input by constructing the inter-dependent regenerative and inter-generative knowledge interaction.
What are the experiences of professionals working with parents with learning disabilities? A meta-ethnography
Authors: Pytlowana Agnieszka , Stenfert Kroese Biza 
Published: February 2021

PurposeIt has been recommended that social, health and other relevant professionals work collaboratively to support parents with learning disabilities (LD) and their children. A number of qualitative studies have investigated the experiences of professionals who work with parents with LD. A synthesis of these experiences has not as yet been produced, and therefore, the purpose of this paper is to review how professionals experience working with parents with LD to inform practice guidelines on how parents with LD can be supported most effectively.Design/methodology/approachA systematic search took place using five databases and 15 peer-reviewed papers were identified based on the relevant inclusion and exclusion criteria. The quality of each included paper was systematically evaluated. Meta-ethnography was used to synthesise the qualitative data from the identified studies.FindingsThe synthesis offered six themes: concerns about knowledge and experience, the importance of and difficulties with available support, the importance of and challenges with liaison with and between professionals, differences in power, conflicting priorities – parents or children?, the personal impact on professionals.Originality/valueThe results are discussed in the context of previous research. Recommendations for future research and practice innovation are made.
Between diagnostic precision and rapid decision‐making: Using institutional ethnography to explore diagnostic work in the context of Cancer Patient Pathways in Norway
Authors: Næss Siri Christine K. , Håland Erna 
Published: February 2021

AbstractAlongside other Nordic countries, the Norwegian government has introduced Cancer Patient Pathways (CPPs) for faster diagnostic assessment and timely treatment to improve the quality of cancer care. A key aspect of CPPs is the introduction of time limits for each phase of the diagnostic investigation. Occurring simultaneously are ongoing advances in medical technology, complicating the process of diagnosing and treating cancer. In this article, using institutional ethnography, we examine: how does the CPP policy influence physicians' experiences of diagnostic work? Data were collected from May 2018 to May 2019, through semi‐structured interviews with physicians across five hospitals in Norway (N = 27). Our findings indicate that the implementation of various strategies aimed at enhancing quality in cancer care collide, compelling physicians to negotiate between diagnostic precision and rapid decision‐making. We conclude that attention to interfaces between multiple guidelines and their implications for practice is crucial for understanding and developing quality of care.
On the role of the written accent mark in visual word recognition in Spanish
Authors: Gutiérrez‐Palma Nicolás , Shelton Michael , Ramos‐Álvarez Manuel Miguel 
Published: February 2021

BackgroundPrevious research has shown that syllables are important units in visual word recognition in Spanish. If they are treated as real phonological units, then other related phonological features such as lexical stress (syllable prominence) may also play a role in this process. At times, lexical stress is the only difference between minimal pairs in Spanish (e.g., sábana ‘sheet’ vs sabana ‘savannah’). These words are usually distinguished by an accent mark. This research examines whether lexical stress is used in visual word recognition and the role of the written accent mark in this process.MethodsIn a lexical decision task, words with an irregular stress pattern according to generative phonological rules (e.g., túnel ‘tunnel’ or mitin ‘meeting’) were compared with regular words (e.g., melón ‘melon’ or grifo ‘faucet’).ResultsIrregular words without an accent mark (mitin) were particularly difficult to recognise. However, irregulars that carried an accent mark were identified significantly more quickly and accurately.ConclusionsThese findings are discussed as evidence that lexical stress may be an important cue in visual word recognition in Spanish, as suggested by previous research in the psycholinguistic and educational fields, and that models of visual word recognition should consider the impact of the accent mark in languages such as Spanish.
People’s preferences for self‐management support
Authors: Iglesias Urrutia Cynthia P. , Erdem Seda , Birks Yvonne F. , Taylor Stephanie J. C. , Richardson Gerry , Bower Peter , van den Berg Bernard , Manca Andrea 
Published: February 2021

AbstractObjectiveTo identify and assess the preferences of people with long‐term health conditions toward generalizable characteristics of self‐management support interventions, with the objective to inform the design of more person‐centered support services.Data SourcesPrimary qualitative and quantitative data collected on a representative sample of individuals with at least one of the fifteen most prevalent long‐term conditions in the UK.Study DesignTargeted literature review followed by a series of one‐to‐one qualitative semistructured interviews and a large‐scale discrete choice experiment.Data CollectionDigital recording of one‐to‐one qualitative interviews, one‐to‐one cognitive interviews, and a series of online quantitative surveys, including two best‐worst scaling and one discrete choice experiment, with individuals with long‐term conditions.Principal FindingsOn average, patients preferred a self‐management support intervention that (a) discusses the options available to the patient and make her choose, (b) is individual‐based, (c) face to face (d) with doctor or nurse, (e) at the GP practice, (f) sessions shorter than 1 hour, and (g) occurring annually for two‐third of the sample and monthly for the rest. We found heterogeneity in preferences via three latent classes, with class sizes of 41% (C1), 30% (C2), and 29% (C3). The individuals’ gender [P < 0.05(C1), P < 0.01(C3)], age [P < 0.05(C1), P < 0.05(C2)], type of long‐term condition [P < 0.05(C1), P < 0.01(C3)], and presence of comorbidity [P < 0.01(C1), P < 0.01(C3), P < 0.01(C3)] were able to characterize differences between these latent classes and help understand the heterogeneity of preferences toward the above mentioned features of self‐management support interventions. These findings were then used to profile individuals into different preference groups, for each of whom the most desirable form of self‐management support, one that was more likely to be adopted by the recipient, could be designed.ConclusionsWe identified several factors that could be used to inform a more nuanced self‐management support service design and provision that take into account the recipient's characteristics and preferences.
Inequities in access to VA’S aid and attendance enhanced pension benefit to help Veterans pay for long‐term care
Authors: Thomas Kali S. , Corneau Emily , H. Van Houtven Courtney , Cornell Portia , Aron David , M. Dosa David , M. Allen Susan 
Published: February 2021

AbstractObjectiveTo examine characteristics that are associated with receipt of Aid and Attendance (A&A), an enhanced pension benefit for Veterans who qualify on the basis of needing daily assistance, among Veterans who receive pensions.Data sourcesSecondary data analysis of 2016‐2017 national VA administrative data linked with Medicare claims.Study designObservational study examining sociodemographic, medical, and healthcare utilization characteristics associated with receipt of A&A among Veterans receiving pension.Principal findingsIn 2017, 9.7% of Veterans with pension newly received the A&A benefit. The probability of receiving A&A among black and Hispanic pensioners was 4.6 percentage points lower than for white pensioners (95%CI = −0.051, −0.042). Married Veterans receiving pension had a 4.4‐percentage point higher probability of receiving A&A (95%CI = 0.039, 0.048). Most indicators of need for assistance (eg, home health utilization, dementia, stroke) were associated with significantly higher probabilities of receiving A&A, with notable exceptions: pensioners with a diagnosis of Post‐Traumatic Stress Disorder (marginal effect = −0.029 95%CI = −0.037, −0.021) or enrolled in Medicaid (marginal effect = −0.053, 95%CI = −0.057, −0.050) had lower probabilities of receiving A&A. Unadjusted and adjusted rates of receiving A&A among Veterans receiving pension varied by VA medical center.ConclusionsThis study identified potential inequities in receipt of the A&A enhanced pension among a sample of Veterans receiving pension. Increased Veteran outreach, provider education, and VA office coordination can potentially reduce inequities in access to this benefit.
Joint Effect of Alcohol Drinking and Environmental Cadmium Exposure on Hypertension in Korean Adults: Analysis of Data from the Korea National Health and Nutrition Examination Survey, 2008 to 2013
Authors: Choi Yun‐Hee , Huh Da‐An , Moon Kyong Whan 
Published: February 2021

BackgroundHypertension is a common disease found in 1.13 billion adults worldwide. Several animal studies have provided evidence of the joint effect of alcohol drinking and cadmium exposure on hypertension. However, no epidemiologic study has examined the association between these 2 risk factors and hypertension. Therefore, we examined the individual effects of alcohol drinking and cadmium and the joint effect of their coexposure on hypertension in the general population.MethodsWe analyzed data from 8,403 South Korean adults who had been randomly assigned to the Korea National Health and Nutrition Examination Survey from 2008 to 2013. Multiple linear and logistic regression analyses were conducted to estimate the association of alcohol drinking and blood cadmium concentration with blood pressure and the odds ratio (OR) for hypertension.ResultsThe weighted prevalence of hypertension and high‐risk drinking was 25.7 and 13.6%, respectively. The weighted geometric mean of blood cadmium levels was 0.94 μg/L (95% confidence interval [CI]: 0.93 to 0.96). After adjusting for demographic characteristics, anthropometric measurements, health‐related behaviors, and dietary and disease variables, the OR for hypertension in the group with the high‐risk alcohol drinking was 1.67 (95% CI: 1.34 to 2.06) compared with the group without high‐risk alcohol drinking. When the highest and the lowest blood cadmium quartiles were compared, the OR for hypertension was 1.46 (95% CI: 1.15 to 1.86). The positive joint effect of high‐risk drinking and blood cadmium levels was statistically significant for systolic blood pressure (SBP; p = 0.037) and diastolic blood pressure (DBP; p < 0.001).ConclusionsOur results show that heavy alcohol drinking had a joint effect with cadmium exposure to increase the risk of hypertension. Future efforts are needed to reduce alcohol drinking and environmental cadmium exposure to prevent hypertension in the general population.
A systematic review of the barriers to implementing human papillomavirus vaccination programs in low‐ and middle‐income countries in the Asia‐Pacific
Authors: Ver Abbygail Therese , Notarte Kin Israel , Velasco Jacqueline Veronica , Buac Kevin Miko , Nazareno John , Lozañes J. Alfred , Antonio Dominic , Bacorro Warren 
Published: February 2021

AbstractAim: The increasing burden of human papillomavirus (HPV)‐related diseases in low‐ and middle‐income countries (LMICs) could be alleviated by effective HPV vaccination programs. In this systematic review, we examined barriers to introduction, implementation, and/or sustainability of HPV vaccination programs in LMICs in the Asia‐Pacific region (AP‐LMICs).Methods: A systematic search of literature from the past 10 years (2010‐2019) was performed through PubMed, Cochrane CENTRAL, and Google Scholar. Studies were included if they reported barriers to HPV vaccination in AP‐LMICs. All study designs were included except commentaries and editorials. The journal articles were assessed using the Joanna Briggs Institute critical appraisal checklists.Results: A total of 46 eligible articles were included. An increase in publications was noted from 2010 to 2019. Barriers were diverse and were classified into four levels––government, healthcare providers (HCPs), society, and individual. The top specific barriers that were identified across AP‐LMICs are lack of funding and political support at the government level, lack of awareness among HCP and lack of vaccination programs at the level of health providers, and the perceived cost/benefit ratio for the individual level.Conclusion: Barriers to successful implementation of HPV vaccination programs differ among Asia‐Pacific LMICs. Policymakers will need to evaluate the relative importance of these barriers in their target areas and population in order to draft an effective dissemination and implementation strategy.
Assessing comfort level with pediatric skin specimens among dermatopathologists and pediatric pathologists: A national cross‐sectional survey
Authors: Enos Tyler , Hughes Connor , Kelley Shannon , Mir Adnan , Rakheja Dinesh , Vandergriff Travis 
Published: February 2021

AbstractBackgroundCutaneous histopathologic diagnoses in children often differ from those in adults. Depending on practice setting, these specimens may be evaluated by dermatopathologists or pediatric pathologists. We sought to determine whether comfort level with pediatric dermatopathology is associated with prior training, pediatric dermatopathology exposure during fellowship, career duration, or specimen subtype.MethodsWe surveyed dermatopathologists and pediatric pathologists practicing in the United States. Training and practice variables were evaluated by multivariable regression for association with comfort level.ResultsOf the 156 respondents, 72% were dermatopathologists (response rate 11.6%) and 28% were pediatric pathologists (response rate 9.3%). Dermatopathologists reported higher comfort overall (P < .001); this was also true for inflammatory dermatoses and melanocytic neoplasms (P < .001). Thirty‐four percent and 75% of dermatopathologists and pediatric pathologists, respectively, reported lower comfort with pediatric skin specimens than their usual cases. Pediatric pathologists were 28% more likely to refer these cases to colleagues. Among dermatopathologists, dermatology‐trained were more comfortable than pathology‐trained colleagues interpreting inflammatory dermatoses (P < .001).ConclusionsPathologists' comfort with pediatric dermatopathology varied significantly based upon prior training, career duration, and specimen subtype. These results suggest opportunities for improving education in this domain.
“‘Othering’ with Grace and Courage”
Authors: Kärkkäinen Veli‐Matti 
Published: February 2021

AbstractThis essay considers the complexity and dynamic of seeking to balance an openness to the religious “other” and their beliefs with the honest acknowledgement of real and often deep incommensurability between one's own and the other's deepest convictions. This kind of hospitable and mutually edifying encounter is possible by putting into practice the method of comparative theology which, while urging the faithful in every tradition to establish their own religious identity, also facilitates learning from the other and makes room for sharing one's own testimony. Not only theological and confessional but also autobiographical and life narratives matter in this process.
Aetiologies and factors associated with poor clinical outcomes in rhabdomyolysis: a retrospective cohort study in an Australian trauma centre
Authors: Khu Yin Li , Lewis Benjamin , Blackshaw Lucinda , Tan Suzanne May Quinn , Bayfield Anna , Schneider Hans Gerhard , Liew Danny , Aung Ar Kar 
Published: February 2021

AbstractRhabdomyolysis is a clinical syndrome with significant morbidity and mortality that occurs as a result of traumatic and non‐traumatic aetiologies. Acute kidney injury, the need for dialysis, and death, can occur due to rhabdomyolysis. This study explores the aetiologies, clinical outcomes and associated factors for poor outcomes in a cohort of patients with rhabdomyolysis in a tertiary trauma centre in Australia.