bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benefits and limitations of telegenetics: A literature review
Authors: Gorrie Anita , Gold Judy , Cameron Carolyn , Krause Molly , Kincaid Helen 
Published: April 2021

AbstractTelegenetics involves the use of technology (generally video conferencing) to remotely provide genetic services. A telegenetics platform is critical for those with limitations or vulnerabilities compromising their ability to attend clinic in‐person, including individuals in rural areas. As the demand for remote genetics services increases, and amidst the COVID‐19 pandemic with social distancing practices in place, we conducted a literature review to examine the benefits and limitations of telegenetics and explore the views of patients and health professionals utilizing telegenetics. Searches of the PubMed database identified 21 relevant primary studies for inclusion. The majority of studies found acceptability of telegenetics to be high among patients and health professionals and that telegenetics provided access to genetics services for underserved communities. The main benefits cited include cost‐effectiveness and reduction in travel time for genetics services providing outreach clinics and patients who would otherwise travel long distances to access genetics. Patients appreciated the convenience of telegenetics including the reduced wait times, although a minority of patients reported their psychosocial needs were not adequately met. Eight studies compared outcomes between telegenetics and in‐person services; findings suggested when comparing telegenetics patients to their in‐person counterparts, telegenetics patients had a similar level of knowledge and understanding of genetics and similar psychological outcomes. Some studies reported challenges related to establishing rapport and reading and responding to verbal cues via telegenetics, while technical issues were not generally found to be a major limitation. Some service adaptations, for example, counseling strategies, may be required to successfully deliver telegenetics. Further research may be necessary to gather and examine data on how telegenetics outcomes compare to that of in‐person genetic counseling and adapt services accordingly.
Development, validation, and comparison of a nomogram based on radiologic findings for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas: An international multicenter study
Authors: Kim Hyeong Seok , Song Wookyeong , Choo Wonho , Lee Sungyoung , Han Youngmin , Bassi Claudio , Salvia Roberto , Marchegiani Giovanni , Wolfgang Christopher L. , He Jin , Blair Alex B. , Kluger Michael D. , Su Gloria H. , Kim Song Cheol , Song Ki‐Byung , Yamamoto Masakazu , Hatori Takashi , Yang Ching‐Yao , Yamaue Hiroki , Hirono Seiko , Satoi Sohei , Fujii Tsutomu , Hirano Satoshi , Lou Wenhui , Hashimoto Yasushi , Shimizu Yasuhiro , Del Chiaro Marco , Valente Roberto , Lohr Matthias , Choi Dong Wook , Choi Seong Ho , Heo Jin Seok , Motoi Fuyuhiko , Matsumoto Ippei , Lee Woo Jung , Kang Chang Moo , Shyr Yi‐Ming , Wang Shin‐E , Han Ho‐Seong , Yoon Yoo‐Seok , Besselink Marc G. , van Huijgevoort Nadine C. M. , Sho Masayuki , Nagano Hiroaki , Kim Sang Geol , Honda Goro , Yang Yinmo , Yu Hee Chul , Yang Jae Do , Chung Jun Chul , Nagakawa Yuichi , Seo Hyung Il , Lee Seungyeoun , Kim Hongbeom , Kwon Wooil , Park Taesung , Jang Jin‐Young 
Published: April 2021

AbstractBackgroundAlthough we previously proposed a nomogram to predict malignancy in intraductal papillary mucinous neoplasms (IPMN) and validated it in an external cohort, its application is challenging without data on tumor markers. Moreover, existing nomograms have not been compared. This study aimed to develop a nomogram based on radiologic findings and to compare its performance with previously proposed American and Korean/Japanese nomograms.MethodsWe recruited 3708 patients who underwent surgical resection at 31 tertiary institutions in eight countries, and patients with main pancreatic duct >10 mm were excluded. To construct the nomogram, 2606 patients were randomly allocated 1:1 into training and internal validation sets, and area under the receiver operating characteristics curve (AUC) was calculated using 10‐fold cross validation by exhaustive search. This nomogram was then validated and compared to the American and Korean/Japanese nomograms using 1102 patients.ResultsAmong the 2606 patients, 90 had main‐duct type, 900 had branch‐duct type, and 1616 had mixed‐type IPMN. Pathologic results revealed 1628 low‐grade dysplasia, 476 high‐grade dysplasia, and 502 invasive carcinoma. Location, cyst size, duct dilatation, and mural nodule were selected to construct the nomogram. AUC of this nomogram was higher than the American nomogram (0.691 vs 0.664, P = .014) and comparable with the Korean/Japanese nomogram (0.659 vs 0.653, P = .255).ConclusionsA novel nomogram based on radiologic findings of IPMN is competitive for predicting risk of malignancy. This nomogram would be clinically helpful in circumstances where tumor markers are not available. The nomogram is freely available at http://statgen.snu.ac.kr/software/nomogramIPMN.
Design of experiments for development and optimization of a liquid chromatography coupled to tandem mass spectrometry bioanalytical assay
Authors: Thorsteinsdóttir Unnur Arna , Thorsteinsdóttir Margrét 
Published: April 2021

AbstractDesign of experiments (DoE) is a valuable tool for the optimization of quantitative bioanalytical methods utilizing liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS). Liquid chromatography mass spectrometry (LC–MS) is composed of several processes, including, liquid introduction and analyte ionization. The goal is to transfer analytes from atmospheric pressure to vacuum and maintain conditions that are compatible for both LC and MS. These processes involve many experimental factors which need to be simultaneously optimized to obtain maximum sensitivity and resolution at minimum retention time. In this tutorial, the basic concepts of DoE will be explained with focus on practical use of DoE. Three case studies optimized with DoE for liquid chromatography tandem mass spectrometry (LC–MS/MS) quantitative assays will then be presented.
Molecular and clinical epidemiological features of human astrovirus infections in children with acute gastroenteritis in Shandong province, China
Authors: Huang Deyu , Wang Zheng , Zhang Fengjuan , Wang Ting , Zhang Guanyou , Sai Lintao 
Published: April 2021

AbstractHuman astrovirus (HAstV) is one of the most common causative agents of acute gastroenteritis in children with an infection rate estimated to range from 2% to 9% worldwide. This study was aimed at investigating the molecular and clinical epidemiological features of human astrovirus infections in children under 5 years old with acute gastroenteritis in Shandong province, China from July 2017 to June 2018. In total, 376 fecal samples and the corresponding clinical information were collected and analyzed. HAstV infections were detected in all age groups with an overall positive rate of 8.51%. In addition to acute diarrhea, the main clinical manifestations were fever, abdominal pain, vomiting, and dehydration, in which fever was the most common complication. Infections could be seen throughout the year with a peak in the colder season. Four genotypes were detected in which HAstV‐1 was the most prevalent genotype with a prevalence of 78.12%, followed by HAstV‐5 (9.38%), MLB‐1 (9.38%), and MLB‐2 (3.12%). HAstV‐1 strains were classified as lineage 1a, 1b, and 1d, in which lineage 1a strains were the most prevalent followed by lineage 1b and lineage 1d strains. All HAstV‐5 strains were classified as lineage 5b and no other lineages were detected. The results showed that HAstV infection was an important cause of acute gastroenteritis among children under 5 years old in Shandong province. Given that their disease spectrum had been broadened, HAstVs should be paid more attention, not only as a causative agent of acute gastroenteritis but also as a potential pathogen of unexpected diseases.
Home parenteral nutrition in older vs younger patients: Clinical characteristics and outcomes
Authors: Daoud Dane Christina , Cartagena Elena M. S. , Schwenger Katherine J. P. , Somlaw Nicha , Gramlich Leah , Whittaker Scott , Armstrong David , Jurewitsch Brian , Raman Matreyi , Duerksen Donald R. , McHattie James D. , Allard Johane P. 
Published: April 2021

AbstractBackgroundThere is a demographic shift toward older patients receiving home parenteral nutrition (HPN), but data on clinical outcomes are limited. The objective of this study was to determine differences between older and younger HPN patients in regard to HPN indications, prescriptions, and outcomes over the first 2 years receiving HPN.MethodsThis was a retrospective analysis of prospectively collected data from HPN adult patients entered in the Canadian HPN Registry. New HPN patients enrolled between 2003 and 2017 and receiving HPN for at least 2 years were selected. Data included demographics, PN prescriptions, catheter‐related bloodstream infections (CRBSIs) over the past year, survival, and quality of life based on Karnofsky Performance Status (KPS).ResultsFour hundred two patients were included: 184 patients were ≥60 years old, and 219 patients were between 18 and 59 years old. There were no differences in the main indications for HPN, body mass index (BMI), and PN prescriptions at baseline. At 2 years, younger patients received more energy from PN than older patients (27.9 vs 19.6 kcal/kg; P < .001), but BMI remained comparable. There were fewer CRBSIs in the older group (20% vs 36%, P = .0023), but 78% of younger patients remained alive vs 69% in the older group (P = .0401). In those alive, the proportion of patients continuing to receive HPN was comparable and the proportion of patients with a KPS ≥60.ConclusionsOlder HPN patients have similar clinical characteristics as younger patients but have fewer CRBSIs and higher 2‐year mortality.
An optimized organic acid human sensory sourness analysis method
Authors: Mao Yuezhong , Tian Shiyi , Qin Yumei , Cheng Shiwen 
Published: April 2021

AbstractBACKGROUNDSour taste perception builds on both chemical and physiological foundations, and plays an important role in food flavor, including that of fruit, beer, wine, and other beverages. A uniform sourness standard and sourness conversion method for researchers and food enterprises is necessary to obtain uniform conclusions.RESULTSThis study established an optimized organic acid sensory sourness analysis and sourness conversion method. It is based on sour sensory difference strength curves, which consist of an absolute threshold value and sensory difference threshold values. Defining the absolute threshold value of citric acid sourness as 1, sourness could be calculated according to the curve. With a logarithmic curve form, the acid sourness indexes (AI) were calculated as 1, 0.74, 0.77, 1.31, and 1.21 for citric, malic, fumaric, lactic, and tartaric acid samples, respectively. Consequently, each acid's sourness and concentration could be obtained and converted. Single acid and mixed acid sourness comparison evaluation's result implied that the novel method was more accurate (91.7–100%) than the hydrogen ion concentration method.CONCLUSIONThe novel sourness determination and conversion equation would provide more accurate sourness standard and calculation method in food sensory areas. © 2021 Society of Chemical Industry.
Analytical capabilities of micellar liquid chromatography and application to residue and contaminant analysis: A review
Authors: Patyra Ewelina , Kwiatek Krzysztof 
Published: April 2021

AbstractGreen chemistry is the use of chemistry to reduce or eliminate the use of generation of feedstocks, products, by‐products, solvents, reagents, etc. that are hazardous to human health or the environment. One of the branches of green chemistry is micellar liquid chromatography. Micellar liquid chromatography is a reversed‐phase liquid chromatographic mode with mobile phases containing a surfactant above its critical micellar concentration. The applications of micellar liquid chromatography for the determination of numerous compounds in pharmaceutical formulation, biological samples, food, environmental samples, and feeds have been growing rapidly. Micellar liquid chromatography technique has several advantages over other chromatographic techniques. Its main advantage is the small amount of organic modifiers used such as acetonitrile and methanol and the safety and recyclability of the mobile phase. In our work, we discuss the development of “green chemistry” and present what micellar liquid chromatography is. This article presents application methods with the use of micellar liquid chromatography for analysis on antibacterial substances, melamine, biogenic amines, plant protection products, flavonoids, as well as peptides in biological matrices such as milk, eggs, tissues, honey, and feed.
Characterization of galacto‐oligosaccharides using high‐performance anion exchange chromatography‐tandem mass spectrometry
Authors: Chen Yongjing , Liu Yan 
Published: April 2021

AbstractThe analysis of complex oligosaccharide mixtures remains a challenge in the field of analytical chemistry. In this work, two commercial galacto‐oligosaccharides samples were characterized using high‐performance anion exchange chromatography coupled to mass spectrometry. The isomeric oligosaccharides were resolved with high resolution. The structures of the individual isomers with a degree of polymerization up to 6 were analyzed using targeted selected ion monitoring with data‐dependent tandem mass spectrometry, with additional in‐source collision‐induced dissociation.
Inverted Nasal Papilloma Affecting Ears and Pulmonary Parenchyma: Case Report
Authors: Vieira Tiago Fraga , de Castro Denaro Mariana Moreira , da Silva Camila Braz Rodrigues , de Pinho Lilia Gama , Ferreira Luiza Costa Villela , Coelho Luis Eduardo Ribeiro , de Castro Mirian Cabral Moreira 
Published: April 2021

Inverted papilloma is a rare sinonasal neoplasm. It can be locally invasive and potentially degenerate to a malignant tumor.We present a case report of a 36‐year‐old woman who was treated for nasal inverted papilloma for over 10 years and presented bilateral temporal bone, and pulmonary involvement. Several procedures were performed to completely remove the tumor. Even without evidence of malignant degeneration, the patient continued battling tumor recurrences. To the best of our knowledge, this report presents the first case of a multicentric inverted papilloma with nasal, bilateral temporal bone, and pulmonary metachronous localization. Laryngoscope, 131:E2640–E2642, 2021
Knowledge production on predatory publishing: A systematic review
Authors: Mertkan Sefika , Onurkan Aliusta Gulen , Suphi Nilgun 
Published: April 2021

AbstractThe systematic review of the research reported in this paper was conducted within the context of efforts to understand and combat predatory publishing, a new but fast‐growing area of research. It synthesizes the trends observed in knowledge production in predatory publishing, with a particular focus on the volume and distribution over time within different journals. It also looks at the composition of the predatory publishing literature in terms of the type of study, methods, topics, field of study, and contexts where research was conducted. Data were extracted from ERIC, Web of Science, and Scopus and identified 228 articles for evaluation published in 171 journals. The results demonstrate that the literature on predatory publishing is new but fast growing, with 88.6% of studies published since 2016. Only 37.3% reported empirical research, and the majority of these were quantitative studies with weak statistical tests. Medical journals carried the most articles. We conclude that scholarship on predatory publishing is in the early stages of development, and it is thinly distributed across journals, fields, and research contexts. It was surprising to find no studies in leading higher education journals, and this study reveals a research area that is still developing.
Dynamic macromolecular composition and high exudation rates in Prochlorococcus
Authors: Roth‐Rosenberg Dalit , Aharonovich Dikla , Omta Anne Willem , Follows Michael J. , Sher Daniel 
Published: April 2021

AbstractEvery living cell is composed of macromolecules such as proteins, DNA, RNA, and pigments. The ratio between these macromolecular pools depends on the allocation of resources within the organism to different physiological requirements, and in turn affects biogeochemical cycles of elements such as carbon, nitrogen, and phosphorus. Here, we present detailed measurements of the macromolecular composition of Prochlorococcus MIT9312, a representative strain of a globally abundant marine primary producer, as it grows and declines due to nitrogen starvation in laboratory batch cultures. As cells reached stationary stage and declined, protein per cell decreased by ~ 30% whereas RNA per cell and pigments per cell decreased by ~ 75%. The decline stage was associated with the appearance of chlorotic cells, which had higher forward scatter (a proxy for cell size) but lower chlorophyll autofluorescence, as well as with changes in photosynthetic pigment composition. Specifically, during culture decline divinyl‐chlorophyll‐like pigments emerged, which were not observed during exponential growth. These divinyl‐chlorophyll‐like pigments were also observed in natural samples from the Eastern Mediterranean. Over 90% of the carbon fixed by Prochlorococcus MIT9312 (but not of a different strain, NATL2A) was released into the growth media under these laboratory conditions. Variations in RNA/protein indicate that, broadly defined, the macromolecular composition of Prochlorococcus MIT9312 is more similar to eukaryotic phytoplankton than to marine heterotrophic bacteria, possibly due to the significant investment in photosynthetic machinery of phototrophs.
Acceleration Effect of Dynamic Covalent Chains in a Hard Epoxy Resin on Its Thermally Induced Deformation and Healing Behavior
Authors: Fu Jiajia , Zhao Yang , Zhang Lei , Fu Feiya , Liu Xiangdong 
Published: April 2021

AbstractThe dynamic covalent chain polyester oligomer PCG5 is prepared and applied to epoxy thermoset. Preliminary tests including pattern stamping, healing, shape memory, indentation, and adhesion test of the cured epoxy resin show that PCG5 can accelerate deformation, crack‐healing, and transesterification rates at high temperatures. The transesterification rate and activation energy are quantitatively determined by a newly developed TGA method in the authors' group. This method is used to further realize a virtual acceleration mechanism of PCG5 in the transesterification reaction with cured epoxy resins, pointing out that the increase in cross‐link density and ester concentration improves the mobility of structure units and collision of ester groups. Moreover, introduction of PCG5 doesn't sacrifice glass transition temperatures (Tg) of the cured epoxy resin and strengthens the fiber composites. An 85% recovery in storage modulus and an 88% recovery in tensile strength are achieved after 10 000 cycle's fatigue tests.
Riemann problem for a two‐dimensional steady pressureless relativistic Euler equations
Authors: Zhang Yu , Zhang Yanyan 
Published: April 2021

AbstractWe consider the Riemann problem for a two‐dimensional steady pressureless relativistic Euler equations. The delta shock wave is discovered in the Riemann solutions. It is shown that Dirac delta function develops in the state variable describing the number density of particles. By virtue of a suitable generalized Rankine–Hugoniot relation and entropy condition, we establish the existence and uniqueness for delta‐shock solution. Furthermore, we analyze in detail the interactions of delta shock waves and vacuum states.
Factors Associated with Headache and Nausea During Magnetic Resonance–Guided Focused Ultrasound for Tremor
Authors: Cacho‐Asenjo Elena , Honorato‐Cia Cristina , Nuñez‐Cordoba Jorge M. , Fernandez‐Martinez Miguel , Gonzalez‐Quarante Lain H. , Aviles‐Olmos Iciar , Gorospe María Aranzazu , Panadero Alfredo , Rodríguez‐Oroz María Cruz , Guridi Jorge , Martinez‐Simon Antonio 
Published: April 2021

ABSTRACTBackgroundDuring magnetic resonance–guided focused ultrasound for essential or parkinsonian tremor, adverse events (headache, nausea/vomiting, or anxiety) may alter the outcome of the procedure despite being mostly transient and mild.ObjectivesOur aim was to analyze the relationship between demographic, procedural, and anesthetic characteristics with magnetic resonance/ultrasound‐related events.MethodsThis was a retrospective study at the Clinica Universidad de Navarra of patients undergoing thalamotomy with magnetic resonance–guided focused ultrasound between September 2018 and October 2019. The anesthesia protocol included headache and nausea/vomiting prophylaxis and rescue therapy. Dexmedetomidine was used for anxiolysis in some patients after thorough multidisciplinary assessment.ResultsA total of 123 patients were included. Headache was directly related to skull density ratio (P < 0.001) and skull thickness (P = 0.02). Patients with a skull density ratio less than 0.48 had 3 times the odds of experiencing moderate or severe headache (odds ratio [OR], 3.08; 95% confidence interval [CI], 1.21–7.82) and had a higher odds of aborting sonication due to pain. Sex was associated with increased nausea (P = 0.007). Women had 4 times the odds of nausea than men (OR, 4.4; 95% CI, 1.61–12.11). Dexmedetomidine did not reduce headache or nausea incidence. Patients who received dexmedetomidine had a higher number (P = 0.01) and total minutes of sonication (P = 0.01).ConclusionsPatients with lower skull density ratios and higher skull thicknesses could benefit from an aggressive analgesic prophylaxis. Women are more likely to experience nausea. Dexmedetomidine did not reduce headache and nausea, but increased the number and duration of sonications. Its exact effect on tremor is still unclear.