bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Systemic Treatments of Nail Psoriasis: A Systemic Literature Review and Meta-Analysis
Authors: Zhang Xuan , Xie Bingbing , He Yanling 
Published: February 2021

Importance: Nail involvement is a common condition in patients with psoriasis. The treatment of nail psoriasis is considered challenging and is often left untreated by physicians.Objective: To assess the efficacy of current systemic treatments on nail psoriasis.Data Sources: PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched for relevant articles from inception to September 1, 2020. Included articles were restricted to English language and human studies.Study Selection: This was a systematic literature review with meta-analysis. Thirty-five random control trials that evaluated systemic therapies for nail psoriasis were selected in the systemic review. Among them, we retained 14 trials for meta-analysis.Data Extraction and Synthesis: This study was conducted in accordance with the preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. All steps were performed by two independent investigators, and any disagreements were resolved by a third investigator. Meta-analysis of aggregated study data was conducted to assess therapeutic efficacy. The use of random-effects model was based on high heterogeneity as a variable endpoint in different studies.Main Outcomes and Measures: Therapeutic effects on nail psoriasis were expressed in terms of effect sizes with 95% CIs.Results: We included 35 random control trials (RCTs) in this systemic review. At baseline, a high prevalence (62.1%) of nail psoriasis was confirmed. The meta-analysis included 14 trials highlighting that biologic and small-molecule therapies were effective in treating nail psoriasis with variable effect size magnitudes [−0.89 (−1.10, −0.68), I2 = 84%]. In particular, tofacitinib and ixekizumab showed the most significant scale of effect size magnitudes in treating nail psoriasis (−1.08 points and −0.93 points, respectively). We also found that a higher dose of tofacitinib and ixekizumab had similar effectiveness, and anti-IL-17 agents seem to be superior in effectiveness compared to anti-TNF-α therapies in the treatment of nail psoriasis. However, these results must be displayed carefully as variable endpoints in different studies.Conclusions and Relevance: This study provides a comprehensive overview of systemic treatments for nail psoriasis. For patients with psoriatic nail damage who are candidates of systemic therapies, the priority should be given to administering biologic and small-molecule therapies, especially anti-IL-17 drugs.
The Associations Between Sleep Architecture and Metabolic Parameters in Patients With Obstructive Sleep Apnea: A Hospital-Based Cohort Study
Authors: Feng Nana , Yang Jundong , Xu Huajun , Zhang Chujun , Wang Fan , Wu Xiaolin , Gu Meizhen 
Published: February 2021

Background and Objectives: The associations between objective sleep architecture and metabolic parameters have been rarely studied in patients with obstructive sleep apnea (OSA). Here, we evaluated the associations between objective sleep measures derived via polysomnography (PSG) and metabolic parameters.Methods: A total of 2,308 subjects with suspected OSA were included. We measured common metabolic parameters such as body mass index (BMI) and glucose, insulin, blood pressure, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels. All subjects underwent full-night PSG. PSG sleep parameters included total sleep time (TST), time spent in slow-wave sleep (SWS) and rapid eye movement (REM) sleep, sleep efficiency, and the microarousal index (MAI).Results: The TST correlated with the BMI, glucose level, and systolic blood pressure. The SWS/TST ratio correlated with BMI and glucose, TC, and TG levels. The REM/TST ratio correlated with BMI, glucose, insulin, and TG levels, and diastolic blood pressure. We found significant relationships between sleep efficiency and BMI, glucose levels, and TG levels. The MAI was significantly correlated with all metabolic parameters. After adjustment for age, gender, smoking status, alcohol use, apnea hypopnea index, and oxygen desaturation index (ODI), multiple linear regression analysis showed that the MAI was independently associated with glucose level, TC, HDL, and LDL. REM/TST ratio was positively associated with diastolic blood pressure but negatively associated with glucose metabolism.Conclusions: Though some independent correlation between sleep and metabolic parameters was confirmed, only weak associations were observed, suggesting a clinically negligible influence of sleep structure. Further prospective studies are warranted to confirm our findings.
Re-Clustering and Profiling of Digestive System Tumors According to Microenvironment Components
Authors: Wang Yongwei , Guo Sen , Chen Zhihong , Bai Bing , Wang Shuo , Gao Yaxian 
Published: February 2021

BackgroundImmunotherapy has become the most promising therapy in digestive system tumors besides conventional chemotherapy and radiotherapy. But only a few patients can benefit from different types of immunotherapies, such as immune checkpoint blockade (ICB). To identify these ICB-susceptible patients, methods are urgently needed to screen and profile subgroups of patients with different responsiveness to ICB.MethodsThis study carried out analysis on patients with digestive system tumors that were obtained from Cancer Genome Atlas (TCGA) cohorts. The analyses were mainly performed using GraphPad Prism 7 and R language.ResultsWe have quantified the microenvironmental components of eight digestive system tumor patients in TCGA cohorts and evaluated their clinical value. We re-clustered patients based on their microenvironment composition and divided these patients into six clusters. The differences between these six clusters were profiled, including survival conditions, enriched biological processes, genomic mutations, and microenvironment traits. Cluster 3 was the most immune-related cluster, exhibiting a high infiltration of non-tumor components and poor survival status, along with an inhibitory immune status, and we found that patients with high stromal score indicated a poor response in ICB cohort.ConclusionsOur research provides a new strategy based on the microenvironment components for the reclassification of digestive system tumors, which could provide guidance for prognosis judgment and treatment response prediction like ICB.
Dissecting Outcomes: Should Cytoreductive Nephrectomy Be Performed for Patients With Metastatic Renal Cell Carcinoma With Sarcomatoid Dedifferentiation?
Authors: Adashek Jacob J. , Zhang Yumeng , Skelton William Paul , Bilotta Alyssa , Chahoud Jad , Zemp Logan , Li Jiannong , Dhillon Jasreman , Manley Brandon , Spiess Philippe E. 
Published: February 2021

BackgroundIt is highly contested whether cytoreductive nephrectomy for treating advanced renal cell carcinoma (RCC) with sarcomatoid features (sRCC) benefits overall survival. Patients with sRCC are known to have a poor prognosis, and these tumors have a more aggressive biology than those without sarcomatoid features.MethodsPatients with clear cell RCC or non–clear cell RCC underwent cytoreductive nephrectomy in efforts to improve overall survival (OS). Patients were stratified by presence or absence of histologic sarcomatoid features within tumor samples.ResultsOf 167 patients who underwent cytoreductive nephrectomy, 127 had clear cell RCC, of whom 14 had sarcomatoid features, and 40 had non–clear cell RCC, of whom 13 had sarcomatoid features. Median age of the cohort was 62 years (range, 56.5–69 years). The cohort included 119 male (71.3%) and 48 (28.7%) female patients. Among all patients with advanced RCC, having sRCC had a significantly worse OS after cytoreductive nephrectomy (30 vs 8 months; hazard ratio [HR], 2.88; P &lt;0.0001). Additionally, favorable-risk patients had significantly longer OS compared to intermediate- or poor-risk patients (56 vs 30 vs 10 months; HR, 0.21; P =0.00016). For patients with clear cell RCC, having sRCC conferred a significantly poorer survival (30 vs 9 months; HR, 2.82; P=0.0035). Patients with non–clear cell sRCC also had significantly worse outcomes compared to patients whose tumors did not have sarcomatoid features (30 vs 6.5 months; HR, 3; P =0.009). When patients with sRCC were stratified by whether there was &gt;10% or ≤10% sarcomatoid features present within the sample, there was no significant difference in OS (8 vs 8.5 months; P =0.32).ConclusionsSarcomatoid features within tumor histology confer significantly poor prognosis. Patients with sRCC, regardless of clear cell vs non–clear cell histology, have significantly shorter OS. Even among patients with 10% or less sarcomatoid features, there was no OS benefit to cytoreductive nephrectomy. Based on our findings, there appears to be a limited to no role of cytoreductive nephrectomy if sRCC is identified on pretreatment biopsy. The role of radiomics and pre-operative biopsies may confer significant benefit in this patient population.
Case Report: Systemic Small-Vessel Vasculitis in an Adolescent With Active Ulcerative Colitis
Authors: Bouhuys Marleen , Armbrust Wineke , van Rheenen Patrick F. 
Published: February 2021

Introduction: Small-vessel vasculitis (SVV) is a rare immunological disease that affects arterioles, capillaries and venules. It causes purpura, but can also manifest in other organs, including the gastrointestinal tract. SVV and inflammatory bowel disease (IBD) co-occur more frequently than would be expected by chance.Case description: A 16-year-old girl, who had been diagnosed with ulcerative colitis (UC) 2 years earlier at a general hospital, developed purpura, progressive abdominal pain with frequent bloody diarrhea and frontotemporal headache and swelling while on azathioprine and mesalamine maintenance therapy. Serology was positive for perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) without antiprotease- or myeloperoixidase antibodies. Endoscopy revealed active left-sided UC and atypical ulcerations in the ascending colon. Biopsies of these ulcerations and of affected skin revealed leukocytoclastic vasculitis. Initially this was interpreted as an extraintestinal manifestation of UC that would subside when remission was induced, consequently infliximab was started. Over the next 3 weeks she developed severe burning pain in her right lower leg that progressed to a foot drop with numbness and the purpura progressed to bullous lesions. The diagnosis was adjusted to ANCA-associated vasculitis with involvement of skin, bowel and peripheral nerves. Infliximab was discontinued and induction treatment with high-dose prednisolone and cyclophosphamide was given until remission of SVV and UC was achieved. Subsequently, infliximab induction and maintenance was re-introduced in combination with methotrexate. Remission has been maintained successfully for over 2 years now. The foot drop only partly resolved and necessitated the use of an orthosis.Conclusion: Pediatric patients with IBD who present with purpuric skin lesions and abdominal pain should be evaluated for systemic involvement of SVV, which includes endoscopic evaluation of the gastrointestinal tract. We discuss a practical approach to the diagnosis, evaluation and management of systemic SVV with a focus on prompt recognition and early aggressive therapy to improve outcome.
Clinical Efficacy and Safety of Propranolol in the Prevention and Treatment of Retinopathy of Prematurity: A Meta-Analysis of Randomized Controlled Trials
Authors: Kong Haibo B. , Zheng Guoyuan Y. , He Baomei M. , Zhang Ying , Zhou Qin 
Published: February 2021

Objective: To perform a meta-analysis of randomized controlled trials verifying clinical efficacy and safety of propranolol in pre-term newborns with retinopathy of prematurity (ROP).Methods: We searched the literature databases (Pubmed, Embase, The Cochrane Library, Web of Science, CNKI, WanFang, VIP, CBM) for publications before August 10, 2020, and the World Health Organization's International Clinical Trials Registry and ClinicalTrials.gov for ongoing trials. Randomized controlled trials (RCTs) of propranolol for the prevention or treatment of ROP were included. The quality of the included studies was primarily assessed by the RCT tool of the Cochrane Collaboration. The included studies were quantified using a meta-analysis of relative risk (RR) estimated with a random effect model.Results: Our original search identified 171 articles, and five studies met our criteria. A meta-analysis was performed that showed that infants orally treated with propranolol had a decreased risk of disease progression: stage progression had an RR = 0.65 [95% confidence interval (CI), 0.47–0.88]), plus disease had an RR = 0.43 [95% CI, 0.22–0.82]. The demands for additional treatments had similar protective results: laser photocoagulations had an RR = 0.55 [95% CI, 0.35–0.86]), and intravitreal injection of anti-vascular endothelial growth factor had an RR = 0.45 [95% CI, 0.22–0.90]). The oral administration of propranolol was associated with an increased risk of adverse events (RR = 2.01 [95% CI, 1.02–3.97]). High-risk adverse events included bradycardia, hypotension, not gaining enough weight, bronchospasm, hypoglycemia, apnea, and increasing ventilator need. Subgroup analysis of ROP phases and stages found that the risk in stage 2 ROP of the second phase and the individual risk factors (stage progression, RR = 0.42 [95% CI, 0.27–0.65]; plus disease, RR = 0.40 [95% CI, 0.17–0.93]; laser photocoagulation, RR = 0.31 [95% CI, 0.14–0.68]) have statistically significant differences compared with other phases and stages.Conclusions: Pre-term newborns with ROP, especially in stage 2 ROP of the second phase, who were orally given propranolol have a reduced risk of disease progression and demand for additional treatments, but the safety needs more attention.
Media Exposure to COVID-19 Predicted Acute Stress: A Moderated Mediation Model of Intolerance of Uncertainty and Perceived Social Support
Authors: He Xiangcai , Zhang Yu , Chen Meng , Zhang Jihong , Zou Weixing , Luo Yu 
Published: February 2021

Background: Previous studies have found that disaster-related media exposure could predict acute stress responses. However, few studies have investigated the relationship between media exposure to COVID-19 and acute stress, and less is known about the mechanisms that translate media exposure to COVID-19 into acute stress. The current study explored the impact of media exposure to COVID-19 on acute stress, and examined the mediating role of intolerance of uncertainty (IU) and the moderating role of perceived social support (PSS).Methods: A total of 1,483 Chinese participants (Mage = 27.93 years, SD = 8.45) completed anonymous online questionnaires regarding media exposure to COVID-19, IU, PSS, and acute stress during the COVID-19 outbreak in China.Results: Media exposure to COVID-19 was positively related to acute stress, and IU partially mediated this relationship. The direct effect of media exposure to COVID-19 on acute stress, and the relationship between IU and acute stress, were both moderated by PSS. The impacts of both media exposure to COVID-19 and IU on acute stress were stronger for individuals with low PSS.Limitations: This study collected data in a shorter timeframe, and no assessments occurred during the follow-up, which may prevent us from detecting the changes of the relationships between variables over time. Meanwhile, the self-report method limited the validity of the data due to subjective reporting bias.Conclusions: These findings contribute to a better understanding of how and when pandemic-related media exposure affects acute stress, and provide new perspectives for the prevention to reduce psychological problems following traumatic events.
The Impacts of SARS-CoV-2 Pandemic on Suicide: A Lexical Analysis
Authors: Gonçalves Júnior Jucier , Sales Jair Paulino de , Moreno Marcial Moreira , Rolim-Neto Modesto Leite 
Published: February 2021

Background: Although COVID-19 is a public health emergency, its consequences for the mental health of the population are still scarce. Likewise, its impact on critical situations such as suicide is still poorly explored in the literature. Therefore, this study aimed to analyze in a pioneering way, through lexical and content analysis techniques, the possible impacts of the new COVID-19 pandemic on suicide behavior.Methods: A lexical analysis, whose sample (not probabilistic, i.e., for convenience) was made up of full-length papers (abstracts) and short communications, about suicide behavior in COVID-19 pandemic, in PubMed and Virtual Health Library (VHL) was carried out following a lexical and content analysis using the software IRaMuTeQ, version 0.7 alpha 2.Results: The most frequent active words were suicide behavior (n = 649), covid (n = 439), health (n = 358), mental (n = 268), and social (n = 220). Four lexical classes were found and organized into two large groups: the first group, formed by the classes 2 (“methods for psychological treatment”) and 3 (“strategies to minimize the COVID-19 impacts”), was the most representative, totaling 50.6% of the text segments and second group formed by classes 1 (“signs of clinical depression”) and 4 (“COVID-19 pandemic as a public health problem”) with 49.4% of the text segments.Conclusion: Facing suicide behavior, the direct effects of the COVID-19 pandemic, and the negative feelings and trigger of previous psychiatric illnesses; the measures to deal with the pandemic such as social isolation, decrease in the number of professionals, the opening hours of health establishments, and decrease in the demand for medications; and competing phenomena such as the spread of fake news and lack of empathy are aggressive and potentiating factors of suicidal ideation.
Penggalangan Dana Digital Untuk Yayasan Disabilitas Melalui Produk UMKM Di Era 4.0
Authors: Renowati Hardjosubroto Renowati Hardjosubroto , Untung Rahardja Untung Rahardja , Anggraini Nesti , Yestina Windy 
Published: February 2021

Pengabdian Kepada Masyarakat yang akan dijalankan oleh Universitas Raharja bertujuan untuk menjalankan kegiatan Tri Dharma Perguruan Tinggi sesuai dengan Undang - Undang Nomor 12 tahun 2003 pasal 1 ayat 9. Dimana Perguruan Tinggi wajib menyelenggarakan kegiatan Tridharma Perguruan Tinggi, yaitu kegiatan Pengabdian Kepada Masyarakat selain melakukan penelitian dan pendidikan serta pengajaran. Manfaat yang diperoleh dalam kegiatan ini yaitu mengajak banyak orang dalam melakukan kontribusi dengan menjadi donatur untuk membantu mensejahterakan dan memfasilitasi kebutuhan yang dibutuhkan oleh sasaran dari kegiatan ini yaitu Yayasan Sayap Ibu Banten, sehingga tercipta rasa kasih, dan peduli sesama manusia. Yayasan Sayap Ibu Banten merupakan salah satu hasil perkembangan atau cabang dari Yayasan Sayap Ibu, yang diresmikan pada tahun 2005 silam, tepatnya pada tanggal 01 Oktober. Metode yang digunakan dalam melakukan kegiatan ini berkaitan dengan kewirausahaan, dimana mahasiswa yang terlibat akan dibimbing untuk melakukan pengembangan produk UMKM, mulai dari menentukan kemasan yang akan digunakan, bahan yang digunakan, menyalurkan kreasi dari kreativitas mahasiswa pada kemasan suatu produk sehingga terlihat menarik dan juga bagaimana produk ini akan dipasarkan. Yayasan Sayap Ibu Bintaro ini berfokus dalam melakukan perawatan kepada anak-anak disabilitas yang ditelantarkan oleh orang tuanya. Dimana Masyarakat menjadi donatur terbesar agar yayasan ini tetap terus berjalan dengan membeli produk UMKM yang telah dipasarkan. Oleh karena itu pengembangan produk UMKM ini hadir dan dijalankan, yang nantinya hasil dari penjualan produk UMKM akan diserahkan sepenuhnya kepada Yayasan Sayap Ibu Banten, sehingga Universitas Raharja menjadi salah satu Perguruan Tinggi yang dapat mewakili masyarakat dalam berkontribusi sebagai donatur.
Árbol ABC para el desarrollo lógico matemático en Educación Inicial
Authors: Aguayza-Idrovo Carolina Estefanía , García-Herrera Darwin Gabriel , Erazo-Álvarez Juan Carlos , Narváez-Zurita Cecilia Ivonne 
Published: February 2021

La investigación tuvo por objetivo determinar la efectividad del software educativo Árbol ABC como un recurso didáctico innovador para el desarrollo lógico matemático de los niños de Educación Inicial de la Unidad Educativa San Rafael de Honorato Vásquez. La investigación es de tipo cuasi experimental con pre y postest. Los resultados obtenidos reflejan cambios significativos en el proceso de enseñanza aprendizaje en cuanto al desarrollo lógico matemático de los niños, a pesar de presentar un mínimo de dificultad por parte de los niños en el uso de las herramientas digitales mediadoras como la pizarra digital y el lápiz óptico que se utilizaron para la implementación del software. Se demuestra que la aplicación del software educativo Árbol ABC para el desarrollo lógico matemático en educación inicial fomento significativamente al proceso educativo.
Didáctica invertida y las TIC: Un análisis de utilización en Educación Básica y Bachillerato
Authors: Prieto-Urgilés Fabiola Isabel , García-Herrera Darwin Gabriel , Mena-Clerque Sandra Elizabeth , Erazo-Álvarez Juan Carlos 
Published: February 2021

La investigación tuvo por objetivo determinar la efectividad de la didáctica basada en el aula invertida y TIC en educación básica y bachillerato del Ecuador, se procedió mediante un tipo descriptiva correlacional transversal con prueba de chi-cuadrado, lo cual permitió comprobar la asociación de las variables en estudio. Se determinó que el aula invertida o flip classroom no está siendo aplicada de una manera coherente con los referentes teóricos sobre el tema, lo cual trae consigo: El Aula Invertida no está cumpliendo con su propósito pues la mayoría de los docentes que usan esta metodología, asumen la praxis pedagógica del enfoque tradicional, lo cual refleja la no generación de un aprendizaje activo y reflexivo por parte del estudiante desde la investigación en apoyo de las TIC.
Impacto de COVID-19 en Educación básica y bachillerato: Unidades educativas urbanas de Suscal – Ecuador
Authors: Castro-Castro Luis Antonio , García-Herrera Darwin Gabriel , Ávila-Mediavilla Carlos Marcelo , Erazo-Álvarez Juan Carlos 
Published: February 2021

Se tuvo como objetivo analizar el impacto de COVID-19 en Educación básica y bachillerato: Unidades educativas urbanas de Suscal – Ecuador. Fue realizada en las instituciones educativas ubicadas en el sector urbano del Cantón Suscal de la provincia del Cañar- Ecuador. Es de metodologia descriptiva no experimental. Se afirma que ciertos docentes no contaban con debida capacitacion en las herramientas tecnologicas para enfrentar emergencia sanitaria de COVID-19, por cuanto no usaban frecuentemente la tecnologia de informacion y comunicación para impartir las clases en sus asisgnarutas que corresponden.