bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cloud computing in industrial automation systems
Authors: Mentsiev A U , Kulpeiis Y A , Smagulova K K 
Published: June 2021

Abstract
Automated systems in industries increase production and make things more accurate. These both things give very much profit to the manufacturer. No doubt these automated systems of different types reduced the rate of error and increase efficiency but it was facing some very serious issues like loss of data, security of data, and maintenance of the automated system. These are issues where cloud computing involves resolution and provides solutions to overcome these issues. This paper describes the problems of automated systems in industry and the help of cloud computing for the mitigation of the issues faces by automated systems. In this paper discussion about the future role of cloud computing is described for enhancing the automation in industry.
On the application of a model for assessing the transactional reliability of information systems of industrial enterprises
Authors: Kovalev I V , Kovalev D I , Testoyedov N A , Borovinskii D V , Koltashev A A , Shatrov A K , Bartenev V A 
Published: June 2021

Abstract
The article examines an example of the application of a model for assessing the transactional reliability of information systems of industrial enterprises. This transactional reliability determines the correctness of the calculations performed and the integrity of the data, and, consequently, the characteristics of the quality of software tools that are used in information systems of industrial enterprises to perform control and data processing functions. It is shown that all the parameters of this model can be obtained from the results of testing the system, which makes it possible to construct adequate estimates of the reliability parameters. The calculated indicators obtained using the developed model differed from the real ones by no more than 5%, which indicates the sufficient adequacy of the model. The modern system Microsoft Dynamics 365 for Finance and Operations (Dynamics AX/Axapta) was used as an environment for modeling and analyzing the transactional reliability of software tools.
Information modernization of the general theory of environmental safety ensuring
Authors: Dmitrieva I A , Mileshko L P , Begun O V , Berezhnaya A V 
Published: June 2021

Abstract
A brief analysis of the content of the concept “information” in ecology is given. The purpose of this work is to analyze the features of the information component of the second and third principles of the ensuring environmental safety general theory. It is noted that information interactions in ecological systems play a key role in terms of the possibility of maintaining a balance in them to ensure environmental safety. It is argued that the information components of ecological systems of the environment have a physicochemical meaning, which consists in the reflection of material-energy changes in the form of an information environment (information field) of all subsystems. Information processing can be viewed as a kind of partial modification of self-organization. In open systems (pumped) that give off entropy, information can be acquired. It is the entropy and, of course, the uncertainty of the position of the system that can only increase, i.e. information itself can be nothing more than lost. Thus, the indicated problem seems to be important, essential for the currently achieved level of development of the general theory of ensuring environmental safety and information theory.
Use of silt sludge after biological wastewater treatment for crop yields increasing
Authors: Tikhonova A A , Vladimtseva I V , Mogilevskaya I V , Kolotova O V , Minchenko L A , Spivak M E 
Published: June 2021

Abstract
Researching the possible use of the silt sludge after biological wastewater treatment from the industrial enterprises for increasing the agricultural crops’ yield was spent. Silt sludge is obtained as a result of biological wastewater treatment in column-type aeration tanks. Founded the concentration’s increase of macro - and microelements in the silt sludge, improvement of the sanitary status and decrease of the heavy metals content after its treatment by the enzyme-cavitation method. Low-intensity cavitation with a cavitation number (0.01-0.05) with air oxygen saturation of the sediment (at least 10 mg/m3) allows for deep organic matter mineralization, dehydration pathogenic microflora’s destruction and dehilmintization. Shown the obtained complex fertilization into soil gives it nitrogen, humus and sulfur and increases the winter wheat’s yield.
Investigation of composition and properties of EAF dust for metal reduction
Authors: Kalganov D A , Pavlov D A , Anzulevich A P , Butko L N , Tolkachev V A , Peng Z 
Published: June 2021

Abstract
In this work, we investigated the composition and structure of the dust of electric arc steelmaking furnaces. We considered the process of direct reduction of metals (mainly Zn and Fe) with biochar from EAF dust. For better control over chemical transformations, it is proposed to use microwave heating of a mixture of EAF dust and biochar. Possible chemical and phase transformations for complex oxides in the composition of EAF dust have been determined.
Comparative analysis of CAD software packages for engineering design
Authors: Magomedov I A , Bagov A M , Elmurzaev A A 
Published: June 2021

Abstract
This work is focused on the comparison of two software packages Solidworks and Inventor. The following two software packages are well known for their ability to design and they share a leading position in the market. A comparison of the functionality of the two software packages will be made. The difference will be outlined on the divorce tools they have. The market share of CAD software packages will also be briefly outlined. Both software packages will then be compared for how easy they are to use for customers. Lastly, the availabilities of the following software will be discussed.
Design, fabrication and testing of the package-on-package microcircuit
Authors: Marcinkevich K R , Lunkov P V , Kirienko D A , Putrolaynen V V , Belyaev M A , Yartsev A V 
Published: June 2021

Abstract
The paper presents the results of the development of a package-on-package multichip microcircuit with three-dimensional integration of processor and memory dies. The stages of fabrication the upper part of the microcircuit with several memory dies, which are mounted by the wire bonding method, and the lower part of the microcircuit, on which the processor die is attached by the flip-chip method, are described. After the fabrication of the microcircuit by combining the upper and lower substrates, a multi-stage functional testing of the processor and memory dies is performed using a test board and software loaded into the microcircuit memory.
Capacitive sensors of mechanical strain
Authors: Ignakhin V S , Sekirin I V , Shilovskiy N A 
Published: June 2021

AbstractThe paper reviews recent research and applications of both laboratory prototypes and commercially fabricated capacitance gauges of mechanical strain. Basic operational principles as well as advantageous points of each type of sensors are considered. The prospective areas of applications of the capacitive gauges are briefly considered. The properties of other strain gauges are briefly discussed and compared with those of the capacitive sensors.
Changes in social, psychological and physical well-being in the last 5 years of life of older people with cancer: a longitudinal study
Authors: Pivodic Lara , De Burghgraeve Tine , Twisk Jos , van den Akker Marjan , Buntinx Frank , Van den Block Lieve 
Published: June 2021

Abstract

Background
older people with cancer are at risk of complex and fluctuating health problems, but little is known about the extent to which their well-being changes in the last years of life.

Objective
to examine changes in physical, psychological and social well-being in the last 5 years of life of older people with cancer.

Design
prospective cohort study.

Setting
Belgium, the Netherlands.

Participants
people with a new primary diagnosis of breast, prostate, lung or gastrointestinal cancer, aged ≥70 years, life expectancy &gt;6 months, were recruited from nine hospitals. We analysed data of deceased patients.

Methods
data were collected from participants around diagnosis, and after 6 months, 1, 3 and 5 years through structured questionnaires administered through interviews or as self-report. Outcomes were physical, emotional, social, role functioning (EORTC QLQ-C30), depressive symptoms (GDS-15), emotional and social loneliness (Loneliness Scale). We conducted linear mixed model analyses.

Results
analysing 225 assessments from 107 deceased participants (assessments took place between 1,813 and 5 days before death), mean age at baseline 77 years (standard deviation: 5.2), we found statistically significant deterioration in physical functioning (b = 0,016 [95%confidence interval 0.009–0.023]), depressive symptoms (b = −0,001 [−0.002 to 0.000]) and role functioning (b = 0.014 [0.004–0.024]). Changes over time in emotional and social functioning and in social and emotional loneliness were smaller and statistically non-significant.

Conclusions
care towards the end of life for older people with cancer needs to put their social and psychological well-being at the centre, alongside physical needs. Future research should focus on understanding inter-individual variation in trajectories.
Machine-learning scoring functions trained on complexes dissimilar to the test set already outperform classical counterparts on a blind benchmark
Authors: Li Hongjian , Lu Gang , Sze Kam-Heung , Su Xianwei , Chan Wai-Yee , Leung Kwong-Sak 
Published: June 2021

AbstractThe superior performance of machine-learning scoring functions for docking has caused a series of debates on whether it is due to learning knowledge from training data that are similar in some sense to the test data. With a systematically revised methodology and a blind benchmark realistically mimicking the process of prospective prediction of binding affinity, we have evaluated three broadly used classical scoring functions and five machine-learning counterparts calibrated with both random forest and extreme gradient boosting using both solo and hybrid features, showing for the first time that machine-learning scoring functions trained exclusively on a proportion of as low as 8% complexes dissimilar to the test set already outperform classical scoring functions, a percentage that is far lower than what has been recently reported on all the three CASF benchmarks. The performance of machine-learning scoring functions is underestimated due to the absence of similar samples in some artificially created training sets that discard the full spectrum of complexes to be found in a prospective environment. Given the inevitability of any degree of similarity contained in a large dataset, the criteria for scoring function selection depend on which one can make the best use of all available materials. Software code and data are provided at https://github.com/cusdulab/MLSF for interested readers to rapidly rebuild the scoring functions and reproduce our results, even to make extended analyses on their own benchmarks.
TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia
Authors: Sidibé Hadjara , Khalfallah Yousra , Xiao Shangxi , Gómez Nicolás B , Fakim Hana , Tank Elizabeth M H , Di Tomasso Geneviève , Bareke Eric , Aulas Anaïs , McKeever Paul M , Melamed Ze’ev , Destroimaisons Laurie , Deshaies Jade-Emmanuelle , Zinman Lorne , Parker J Alex , Legault Pascale , Tétreault Martine , Barmada Sami J , Robertson Janice , Vande Velde Christine 
Published: June 2021

Abstract
TDP-43 nuclear depletion and concurrent cytoplasmic accumulation in vulnerable neurons is a hallmark feature of progressive neurodegenerative proteinopathies such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cellular stress signalling and stress granule dynamics are now recognized to play a role in ALS/FTD pathogenesis. Defective stress granule assembly is associated with increased cellular vulnerability and death. Ras-GAP SH3-domain-binding protein 1 (G3BP1) is a critical stress granule assembly factor.
Here, we define that TDP-43 stabilizes G3BP1 transcripts via direct binding of a highly conserved cis regulatory element within the 3ʹ untranslated region. Moreover, we show in vitro and in vivo that nuclear TDP-43 depletion is sufficient to reduce G3BP1 protein levels. Finally, we establish that G3BP1 transcripts are reduced in ALS/FTD patient neurons bearing TDP-43 cytoplasmic inclusions/nuclear depletion.
Thus, our data indicate that, in ALS/FTD, there is a compromised stress granule response in disease-affected neurons due to impaired G3BP1 mRNA stability caused by TDP-43 nuclear depletion. These data implicate TDP-43 and G3BP1 loss of function as contributors to disease.
Repair of O6-carboxymethylguanine adducts by O6-methylguanine-DNA methyltransferase in human colon epithelial cells
Authors: Kostka Tina , Empl Michael T , Seiwert Nina , Geisen Susanne M , Hoffmann Pascal , Adam Janine , Seeger Bettina , Shay Jerry W , Christmann Markus , Sturla Shana J , Fahrer Jörg , Steinberg Pablo 
Published: June 2021

Abstract
The protein O6-methylguanine-DNA methyltransferase (MGMT) is able to repair the mutagenic O6-methylguanine (O6-MeG) adduct back to guanine. In this context, it may protect against colorectal cancer formation associated with N-nitroso compounds. Such compounds may be endogenously formed by nitrosylation of amino acids, which can give rise to mutagenic O6-MeG and O6-carboxymethylguanine (O6-CMG) adducts. It is well established that O6-MeG is repaired by MGMT. However, up to now, whether O6-CMG is repaired by this enzyme remains unresolved. Therefore, the aim of the present study was to analyze the fate of both types of O6-guanine adducts in the presence and absence of MGMT activity. To this end, MGMT activity was efficiently blocked by its chemical inhibitor O6-benzylguanine in human colon epithelial cells (HCECs). Exposure of cells to azaserine (AZA) caused significantly higher levels of both O6-MeG and O6-CMG adducts in MGMT-inhibited cells, with O6-CMG as the more abundant DNA lesion. Interestingly, MGMT inhibition did not result in higher levels of AZA-induced DNA strand breaks in spite of elevated DNA adduct levels. In contrast, MGMT inhibition significantly increased DNA strand break formation after exposure to temozolomide (TMZ), a drug that exclusively generates O6-MeG adducts. In line with this finding, the viability of the cells was moderately reduced by TMZ upon MGMT inhibition, whereas no clear effect was observed in cells treated with AZA. In conclusion, our study clearly shows that O6-CMG is repaired by MGMT in HCEC, thereby suggesting that MGMT might play an important role as a tumor suppressor in diet-mediated colorectal cancer.
Constitutive Hedgehog/GLI2 signaling drives extracutaneous basaloid squamous cell carcinoma development and bone remodeling
Authors: Grachtchouk Marina , Liu Jianhong , Hutchin Mark E , Harms Paul W , Thomas Dafydd , Wei Lebing , Wang Aiqin , Cummings Donelle , Lowe Lori , Garlick Jonathan , Sciubba James , Chinnaiyan Arul M , Verhaegen Monique E , Dlugosz Andrzej A 
Published: June 2021

Abstract
Uncontrolled activation of the Hedgehog (Hh) signaling pathway, operating through GLI transcription factors, plays a central role in the pathogenesis of cutaneous basal cell carcinoma and contributes to the development of several malignancies arising in extracutaneous sites. We now report that K5-tTA;tetO-Gli2 bitransgenic mice develop distinctive epithelial tumors within their jaws. These tumors consist of large masses of highly proliferative, monomorphous, basaloid cells with scattered foci of keratinization and central necrosis, mimicking human basaloid squamous cell carcinoma (BSCC), an aggressive upper aerodigestive tract tumor. Like human BSCC, these tumors express epidermal basal keratins and differentiation-specific keratins within squamous foci. Mouse BSCCs express high levels of Gli2 and Hh target genes, including Gli1 and Ptch1, which we show are also upregulated in a subset of human BSCCs. Mouse BSCCs appear to arise from distinct epithelial sites, including the gingival junctional epithelium and epithelial rests of Malassez, a proposed stem cell compartment. Although Gli2 transgene expression is restricted to epithelial cells, we also detect striking alterations in bone adjacent to BSCCs, with activated osteoblasts, osteoclasts and osteal macrophages, indicative of active bone remodeling. Gli2 transgene inactivation resulted in rapid BSCC regression and reversal of the bone remodeling phenotype. This first-reported mouse model of BSCC supports the concept that uncontrolled Hh signaling plays a central role in the pathogenesis of a subset of human BSCCs, points to Hh/GLI2 signaling as a potential therapeutic target and provides a powerful new tool for probing the mechanistic underpinnings of tumor-associated bone remodeling.
Reinstatement of Cortical Outcome Representations during Higher-Order Learning
Authors: Luettgau Lennart , Porcu Emanuele , Tempelmann Claus , Jocham Gerhard 
Published: June 2021

Abstract
Naturalistic learning scenarios are characterized by infrequent experience of external feedback to guide behavior. Higher-order learning mechanisms like second-order conditioning (SOC) may allow stimuli that were never experienced together with reinforcement to acquire motivational value. Despite its explanatory potential for real-world learning, surprisingly little is known about the neural mechanism underlying such associative transfer of value in SOC. Here, we used multivariate cross-session, cross-modality searchlight classification on functional magnetic resonance imaging data obtained from humans during SOC. We show that visual first-order conditioned stimuli (CS) reinstate cortical patterns representing previously paired gustatory outcomes in the lateral orbitofrontal cortex (OFC). During SOC, this OFC region showed increased functional covariation with amygdala, where neural pattern similarity between second-order CS and outcomes increased from early to late stages of SOC. Our data suggest a mechanism by which motivational value is conferred to stimuli that were never paired with reinforcement.
The Associations Between Bitter and Fat Taste Sensitivity, and Dietary Fat Intake: Are They Impacted by Genetic Predisposition?
Authors: Graham Catherine Anna-Marie , Pilic Leta , Mcgrigor Ella , Brown Megan , Easton Isabelle Jane , Kean Jonathan Nyuma , Sarel Verity , Wehliye Yasmin , Davis Natalie , Hares Nisrin , Barac Deanna , King Alexandra , Mavrommatis Yiannis 
Published: June 2021

Abstract
A relationship between bitter and fat taste sensitivity, CD36 rs1761667 and TAS2R38 has been demonstrated. However, research is scarce and does not take diet into account. This study aimed to explore associations between genetics, fat and bitter taste sensitivity and dietary fat intake in healthy UK adults. A cross-sectional study was carried out on 88 Caucasian participants (49 females and 39 males aged 35 ± 1 years; body mass index 24.9 ± 0.5 kg/m2). Bitter taste sensitivity was assessed using phenylthiocarbamide (PTC) impregnated strips and the general Labeled Magnitude Scale. Fat taste sensitivity was assessed by the Ascending Forced Choice Triangle Procedure and dietary intake with a semi-quantitative food frequency questionnaire. Genotyping for rs713598, rs1726866, rs10246939, and rs1761667 was performed. Participants with TAS2R38 PAV/PAV diplotype perceived PTC strips as more bitter than groups carrying AVI haplotypes (AVI/AVI, P = 1 × 10−6; AVI/AAV, P = 0.029). CD36 rs1761667 was associated with fat taste sensitivity (P = 0.008). A negative correlation between bitter taste sensitivity and saturated fat intake was observed (rs = −0.256, P = 0.016). When combining the CD36 genotypes and TAS2R38 diplotypes into one variable, participants carrying both TAS2R38 AVI haplotype and CD36 A allele had a higher intake of saturated fat compared to carriers of CD36 GG genotype or TAS2R38 PAV/PAV and PAV/AAV diplotypes (13.8 ± 0.3 vs. 12.6 ± 0.5%TEI, P = 0.047) warranting further exploration in a larger cohort.
Cost-Effectiveness and Impact of a Targeted Age- and Incidence-based West Nile Virus Vaccine Strategy
Authors: Curren Emily J , Shankar Manjunath B , Fischer Marc , Meltzer Martin I , Erin Staples J , Gould Carolyn V 
Published: June 2021

Abstract

Background
West Nile virus (WNV) is the leading cause of arboviral disease in the United States and is associated with significant morbidity and mortality. A previous analysis found that a vaccination program targeting persons aged ≥60 years was more cost-effective than universal vaccination, but costs remained high.

Methods
We used a mathematical Markov model to evaluate cost-effectiveness of an age- and incidence-based WNV vaccination program. We grouped states and large counties (≥100 000 persons aged ≥60 years) by median annual WNV incidence rates from 2004 to 2017 for persons aged ≥60 years. We defined WNV incidence thresholds, in increments of 0.5 cases per 100 000 persons ≥60 years. We calculated potential cost per WNV vaccine-prevented case and per quality adjusted life-years (QALYs) saved.

Results
Vaccinating persons aged ≥60 years in states with an annual incidence of WNV neuroinvasive disease of ≥0.5 per 100 000 resulted in approximately half the cost per health outcome averted compared to vaccinating persons aged ≥60 years in the contiguous United States. This approach could potentially prevent 37% of all neuroinvasive disease cases and 63% of WNV-related deaths nationally. Employing such a threshold at a county level further improved cost-effectiveness ratios while preventing 19% and 30% of WNV-related neuroinvasive disease cases and deaths, respectively.

Conclusions
An age- and incidence-based WNV vaccination program could be a more cost-effective strategy than an age-based program while still having a substantial impact on lowering WNV-related morbidity and mortality.
A case of buprenorphine-precipitated withdrawal managed with high-dose buprenorphine
Authors: Quattlebaum Thomas H N , Kiyokawa Miki , Murata Kayla A 
Published: June 2021

Abstract

Background
Buprenorphine–naloxone has a very high affinity for the mu-receptor and can cause precipitated opioid withdrawal, typically more severe than withdrawal that occurs naturally, when administered while a full mu-opioid receptor agonist remains in a person’s system. To avoid precipitated withdrawal, one needs to be in mild to moderate opioid withdrawal at the time of buprenorphine-naloxone induction. Recently, there have been reported cases of precipitated withdrawal occurring in patients taking fentanyl knowingly or unknowingly, despite them being in adequate opioid withdrawal at the time of induction. When this occurs, the current recommendation is to provide 2 mg of buprenorphine–naloxone every 1–2 hours.

Objectives
Describe a case of successful management of buprenorphine-precipitated withdrawal with escalation of the dose of buprenorphine and highlight implications for future management.

Methods
We present a case of a patient with a history of opioid use disorder who was in moderate opioid withdrawal at the time of buprenorphine–naloxone induction and experienced precipitated withdrawal after buprenorphine–naloxone administration.

Results
High-dose buprenorphine–naloxone was given to the patient and precipitated withdrawal subsided after receiving a total of 20 mg. On the next day, the patient had no symptoms of opioid withdrawal and is currently maintained on 16 mg/day.

Conclusion
With the rising prevalence of fentanyl-laced drugs, increased instances of precipitated withdrawal are likely to be encountered. In cases of precipitated withdrawal, giving a high dose of buprenorphine–naloxone rapidly is safe and will allow rapid reversal of withdrawal symptoms.