bluuebunny/crossref_metadata_2025_split huggingface dataset:
Educación y religión en la sociedad democrática
Authors: Serafini Aníbal Tulio 
Published: March 2021

Este artículo tiene como intención analizar la relación entre educación laica y educación religiosa en la sociedad democrática contemporánea, al observarla inquietud que propone esta relación y brindar una posición sobre la posible integración optativa de la educación religiosa en un proyecto educativo democrático, teniendo en cuenta, a su vez, la influencia que las diferentes interpretaciones acerca del rol del estado, la autoridad escolar, el fin pedagógico y la libertad aportan a esta relación. La tesis a desarrollar expresa que la posible integración de una educación religiosa al proyecto educativo democrático no es un problema en sí mismo, sino generado por una interpretación limitada de la educación religiosa, que debe plantearse como una educación espiritual no comprehensiva, y por la forma en que se integra al proyecto educativo democrático. Observar las diferentes concepciones sobre los fines de la educación, la autoridad, el rol del Estado y la libertad resignifica el posible rol de la educación espiritual en un proyecto educativo democrático al expandir e integrar mayor cantidad de dimensiones humanas, defender la pluralidad y el derecho de las minorías que integran la sociedad.
El Crimen Ritual de Ramon Ignacio González
Authors: Miceli José Humberto 
Published: March 2021

El trabajo parte de la descripción y el análisis del crimen de Ramón Ignacio González de 12 años, ocurrido en 2006 en Mercedes. Corrientes. Argentina por el cual resultaron condenadas diez personas que formaban un grupo sectario y cuyo móvil fue el sacrificio y ofrenda del niño.
A partir de esta descripción analítica se pretende extraer características particulares y distintivas del crimen ritual.
Music and Musicians in the Medieval Islamicate World
Authors: Nielson Lisa 
Published: March 2021

During the early medieval Islamicate period (800–1400 CE), discourses concerned with music and musicians were wide-ranging and contentious, and expressed in works on music theory and philosophy as well as literature and poetry. But in spite of attempts by influential scholars and political leaders to limit or control musical expression, music and sound permeated all layers of the social structure.
Lisa Nielson here presents a rich social history of music, musicianship and the role of musicians in the early Islamicate era. Focusing primarily on Damascus, Baghdad and Jerusalem, Lisa Nielson draws on a wide variety of textual sources written for and about musicians and their professional/private environments – including chronicles, literary sources, memoirs and musical treatises – as well as the disciplinary approaches of musicology to offer insights into musical performances and the lives of musicians. In the process, the book sheds light onto the dynamics of medieval Islamicate courts, as well as how slavery, gender, status and religion intersected with music in courtly life. It will appeal to scholars of the Islamicate world and historical musicologists.
Digital Scenography
Authors: O’Dwyer Néill 
Published: March 2021

Shortlisted for the PQ Best Publication Award in Performance Design & Scenography 2023
This book uses digital media theory to explore contemporary understandings of expanded scenography as spatial practice. It surveys and analyses a selection of ground-breaking, experimental digital media performances that comprise a genealogy spanning the last 30 years, in order to show how the arrival of digital technologies have profoundly transformed performance practice. Performances are selected based on their ability to elicit the unique specificities of digital media in new and original ways, thereby exposing both the richness and shortcomings of digital culture.
O’Dwyer argues that contemporary scenography is largely propelled by and dependent on digital technologies and represents a rich, fertile domain, where unbridled creativity can explore new techniques and challenge the limits of knowledge. The 30-year genealogy includes works by Troika Ranch, Stelarc, Klaus Obermaier, Chunky Moves, Onion Lab and Blast Theory. In addition to applying a broad scope of performance analysis and aesthetic theory, the work includes artists’ interviews and opinions.
The volume opens important aesthetic, philosophical and socio-political themes in order to highlight the impact of digital technologies on scenographic practice and the blossoming of experimental interdisciplinarity. Ultimately, the book is an exploration of how evolutionary leaps in technology contribute to how humans think, act, make work, engage one another, and therefore construct meaning and identity.
Divergent Tracks
Authors: Ament Vanessa Theme 
Published: March 2021

By examining three case studies of award-winning soundtracks from cult films—Barton Fink (1991), Bram Stoker’s Dracula (1992), and The English Patient (1996)—it becomes clear that major American film communities, when confronted with the initial technological changes of the 1990s, experienced similar challenges with the inelegant transition from analogue to digital. However, their cultural and structural labor differences governed different results.
Vanessa Ament, author of The Foley Grail (2009), rather than defining the 1990s as an era of technological determinism—a superficial reading—it is best understood as one in which sound professionals became more viable as artists, collaborated in sound design authorship, and influenced this digital transition to better accommodate their needs and desires in their work.
The American Comic Book Industry and Hollywood
Authors: Perren Alisa , Steirer Gregory 
Published: March 2021

The American Comic Book Industry and Hollywood traces the evolving relationship between the American comic book industry and Hollywood from the launch of X-Men, Spider-Man, and Smallville in the early 2000s through the ascent of the Marvel Cinematic Universe, the Arrowverse, and the Walking Dead Universe in the 2010s.
Perren and Steirer illustrate how the American comic book industry simultaneously has functioned throughout the first two decades of the twenty-first century as a relatively self-contained business characterized by its own organizational structures, business models, managerial discourses, production cultures, and professional identities even as it has remained dependent on Hollywood for revenue from IP licensing. The authors’ expansive view of the industry includes not only a discussion of the “Big Two,” Marvel/Disney and DC Comics/Time Warner, but also a survey of the larger comics ecosystem. Other key industry players, including independent publishers BOOM! Studios, IDW, and Image, digital distributor ComiXology, and management-production company Circle of Confusion, all receive attention. Drawing from interviews, fieldwork, archival research, and trade analysis, The American Comic Book Industry and Hollywood provides a road map to understanding the operations of the comic book industry while also offering new models for undertaking trans- and inter-industrial analysis.
Channel 4
Authors: Brown Maggie 
Published: March 2021

This book covers a dramatic decade in the fortunes of Britain's quirkiest broadcaster. It opens in 2009, with the realisation that Channel 4's biggest money spinner, Big Brother, had become a toxic asset and would have to be discarded, at the same time as advertising revenues were shrinking in the wake of the 2008 financial crash.
Maggie Brown's compelling narrative, which draws on interviews with key players in Channel 4's story and unique access to the broadcaster's archives, takes us inside the boardroom battles, changes in senior management and commissioning teams, interventions by the media regulator Ofcom, and the channel's response to a rapidly-changing media and political landscape. Brown describes how the channel, under its new chief executive David Abraham, successfully fought off the threat of privatisation, which became a reality after the Conservatives’ general election victory in 2015. The price for remaining publicly funded was a substantial relocation of Channel 4's operations, with Leeds announced in 2018 as a new ‘regional hub’.
The Channel 4 story is also one of ambitious and innovative programming, with a new director of content, Jay Hunt, instigating radical changes in commissioning and scheduling. Brown traces programming hits and losses during this period, with the departure to competitors of celebrity chefs, Black Mirror and Charlie Brooker, horse racing and Formula 1, and a reappraisal of the remit of institutions such as Channel 4 News and Film 4. But there were successes too, with the 2012 Paralympics helping to restore a public service sheen, and new programmes such as Gogglebox in 2013 connecting with younger audiences, and, in 2016, the coup of taking The Great British Bake Off from its home at the BBC.
The expression of long non-coding RNA HOTAIR in advanced hepatocellular carcinoma and the prognostic correlation of it with sunitinib therapy
Authors: han chenyang , yang yi , guo li , guan qiaobing , ruan shuiliang 
Published: March 2021

Introductionwe also investigated the prognostic correlation between the expression level of lncRNA HOTAIR in tumor tissues and peripheral blood of patients with advanced HCC and sunitinib monotherapy.Material and methodsA total of 60 patients with advanced HCC who received sunitinib monotherapy and another 60 healthy individuals who were examined at the physical examination center during the same period were included in the study. Real-time quantitative PCR (RT-QPCR) was used to determine the relative expression of lncRNA HOTAIR in tumor tissue, adjacent tissue and peripheral blood of HCC patients as well as peripheral blood of healthy controls.ResultsPatients with low lncRNA HOTAIR expression in tumor tissues harbored significantly longer OS (13.4 vs. 9.5, P <0.001) and PFS (8.4 vs6.2, P <0.001) compared to those with high expression. Consistently, patients with low lncRNA HOTAIR expression in peripheral blood had significantly prolonged OS (12.8 vs9.1, P<0.001) and PFS (8.9 vs6.4, P<0.001) compared to those with high expression.Cox regression analysis indicated that the expression level of lncRNA HOTAIR in tumor tissue and peripheral blood was an independent predictive factor of OS and PFS in patients with advanced HCC treated by sunitinib.ConclusionsThe expression of lncRNA HOTAIR was up-regulated in tumor tissue and peripheral blood in patients with advanced HCC. In addition, the expression level of lncRNA HOTAIR was one of the indicator in predicting the effectiveness of sunitinib therapy.
Association of Cytomegalovirus Diseases with Newly Developed Myocardial Infarction and Congestive Heart Failure: Data from a National Population-based Cohort
Authors: Lee Kyoung Hwa , Yoo Seul Gi , Han Kyung Do , La Yeonju , Kwon Da Eun , Han Sang Hoon 
Published: March 2021

IntroductionAnti-cytomegalovirus (CMV) IgG seropositive and/or titer are associated with a higher risk of cardiovascular diseases (CVD). However, it is not clear whether CMV end-organ disease may have relation to development of CVD or chronic heart diseases.Material and methodsIn matched cohort study, National Health Insurance Database covering 50 million people was used to identify 667 patients with CMV diseases and aged ≥20 year-old between 2010 and 2014. 6,670 of control subjects without CMV diseases were matched by age, sex, type 2 diabetes mellitus (DM), hypertension, dyslipidemia, and cohort entry year. Data on CMV disease and heart disease events of myocardial infarction (MI), congestive heart failure (CHF), and atrial fibrillation (AF) were retrieved. Previous events before CMV disease or cohort entry were excluded until January 2006. Subjects were followed until December 2015 in subjects without events and until date of events in subjects with events.ResultsMultivariate regression model adjusted by age, sex, low-income status, type 2 DM, hypertension, dyslipidemia, solid organ transplantation, and hematopoietic stem cell transplantation showed a significantly higher incidence rate of MI (odds ratio [OR]: 2.1, 95% confidence intervals [CI]: 1.0-4.5) and CHF (OR: 3.8, 95% CI: 2.1-6.8) but not AF (OR: 1.9, 95% CI: 0.9-4.0) in patients with CMV disease. Age group of 40-64-year-old with CMV disease had the highest risk for new-onset CHF in this regression model (OR: 9.4, 95% CI: 4.12-21.44, P = 0.029).ConclusionsSymptomatic CMV tissue-invasive diseases were associated with a higher risk of new-onset MI and CHF.
APOA1 (-75 G>A and 83 C>T) and APOB (2488 C>T) polymorphisms and its association with Myocardial Infarction, lipids and apolipoproteins in patients with Type 2 Diabetes Mellitus
Authors: Casillas Fidel , Martínez Fernández Diana , Valle Yeminia , Aceves Ramírez Maricela , Parra-Reyna Brenda , Sarabia Pulido Salvador , Guzmán Sánchez Cesar , Flores Salinas Héctor , Muñoz Valle Francisco , Padilla Gutiérrez Jorge 
Published: March 2021

IntroductionThe increased risk of myocardial infarction (MI) in T2DM is well documented. Polymorphisms in APOA1 and APOB genes allow us to identify new genetic markers in Mexican population with T2DM and MI.Material and methodsWe studied 135 patients with DMT2 and MI (DI); another 85 non-infarcted diabetic individuals with DMT2 but without previous ischemic events (NID) and 242 Healthy subjects (HS), all three groups were selected with the aim to investigate the association between the polymorphisms and infarction when T2DM is present or absent.Results-75 G>A polymorphism: differences were found in genotype distribution between DI and NID individuals (OR: 2.01, CI:1.117-3.623, p= 0.019) with an increased risk for A in the dominant model (OR: 1.77, CI: 1.020-3.084, p= 0.042); also concentrations of ApoA-I for A/A were lower in comparison with G/A (p = 0.038) and LDL-C and HDL-C levels were lower in G/A respecting to G/G carriers. 83 C> T polymorphism of APOA1: for DI individuals: HDL-C was lower in T/T respecting to C/C and triglyceride levels were lower in C/T respect to C/C carriers.ConclusionsThe -75 G>A APOA1 polymorphism could be considered as a susceptibility factor for Myocardial Infarction in individuals with T2DM and 2488 C>T APOB polymorphism is associated with changes in HDL-C and LDL-C and triglycerides in the same group.roup.
Clinical characteristics and management of hyperlipoproteinemia in patients with chronic coronary heart disease in Slovakia
Authors: Studencan Martin , Pella Daniel , Bramlage Peter , Kaszasova Eva 
Published: March 2021

IntroductionA reduction of LDL-cholesterol is beneficial for high-risk patients, including patients with previously documented coronary heart disease (CHD). Data on the overall composition, risk profile, and management of these patients is very limited in Slovakia.Material and methodsThis cross-sectional multicentre observational study was conducted by cardiologists and internists providing outpatient care at 35 sites across Slovakia between 11/2015 and 01/2016. All patients had documented CHD and fulfilled the very high CV risk criteria (ESC recommendations).ResultsA total of 349 patients were recruited, had a mean age of 67.8 years, 67.9% were male, 41% had diabetes and a mean BMI of 29.5 kg/m2. As many as 65.3% had prior myocardial infarction, 59.2% underwent PCI, and 24.1% CABG. At baseline 90.5% of patients reported taking a statin, 10.3% ezetimibe and 5.4% a fibrate. The mean LDL-C level was 2.69±1.02 mmol/L with only 18.6% meeting their treatment target of <1.8 mmol/L. Mean values for TC (4.44mmol/L), HDL-C (1.20 mmol/L, and triglycerides (1.68 mmol/L) were within normal limits. A higher age (aOR 3.40; 95%CI 1.77-6.53) and the use of more than 20 mg per day atorvastatin equivalent dose of a statin (aOR 2.20; 95%CI 1.13-4.28) were associated with treatment target achievement in a multivariable adjusted model while female gender conferring a reduced likelihood (aOR 0.48; 95%CI 0.24-0.99).ConclusionsPatients at high cardiovascular risk in Slovakia are far off the <1.8 mmol/L LDL-C level recommended for the protection from adverse events and achieve their treatment targets less often (18.6%) than in the mean of other countries globally (29.4%).
The incidence and risk factors of bronchopulmonary
dysplasia in extremely preterm infants included in the
Polish National Program for Respiratory Syncytial Virus
Prophylaxis
Authors: Borecka Róża , Lauterbach Ryszard 
Published: March 2021

IntroductionBronchopulmonary dysplasia (BPD) is a chronic lung disease
diagnosed in premature infants, which may cause severe respiratory failure
due to respiratory syncytial virus (RSV) infection. The aim of this study was
to assess the incidence and severity of BPD in infants born before 28 weeks
of gestational age (GA) enrolled into the Polish National Program for RSV
Prophylaxis (PNPRSVP).Material and methodsA retrospective analysis of data on children born
in 2013 included in a prophylaxis program during the seasons 2012–2013
and 2013–2014. The following data were evaluated: the need for oxygen
therapy for at least 28 days and the need for oxygen therapy at 36 weeks of
postmenstrual age (PMA).ResultsThe analysis was carried out in a group of 603 children, who constituted 87.7% of the population entitled to prophylactic administration of
palivizumab. BPD was diagnosed in 80.9% of extremely preterm infants;
however, in 70.7% of cases the disease was mild. The risk factors for the
development of BPD were GA, birth weight and birth weight below the 10th
centile for GA. During the program, the median number of doses received
was 5 (range 1–5), and 82.3% of children received all of the expected doses.ConclusionsAlthough the incidence of BPD in extremely preterm infants
was high, mainly its mild form was recognized. Monitoring of the incidence
of the disease and identifying the risk factors can be carried out effectively
based on long-term data collected during the PNPRSVP.
Diagnostic and prognostic value of 99mTc-Tektrotyd
scintigraphy and 18F-FDG PET/CT in a single-center
cohort of neuroendocrine tumors
Authors: Saponjski Jelena , Macut Djuro , Petrovic Nebojša , Ognjanovic Sanja , Popovic Bojana , Bukumiric Zoran , Sobić Saranović Dragana 
Published: March 2021

IntroductionThe aim was to assess the diagnostic value of 99mTc-Tektrotyd scintigraphy (TCT) and positron emission tomography/computed tomography using F-18 fluorodeoxyglucose (18F-FDG PET/CT) in the detection and
follow-up of neuroendocrine tumors (NETs), and their predictive value for
disease progression.Material and methodsIn this retrospective cohort, TCT and 18F-FDG PET/CT
were performed in 90 patients (37 men, 53 women, mean age 52.7 ±15.1), with
NET. Correlation of Ki67 and tumor grade versus Krenning score and SUVmax
was assessed, Kaplan-Meier analysis was used for progression-free survival
(PFS), and Cox regression analysis was performed to identify the association
between progression-related factors and PFS.ResultsOut of 90, true positive TCT was detected in 56 (62.2%) patients, true
negative in 19 (21.1%), false positive in 4 (4.4%), false negative in 11 (12.2%),
while 18F-FDG PET/CT was true positive in 69 (76.7%) patients, true negative in
10 (11.1%), false positive in 5 (5.5%), false negative in 6 (6.7%). Mean 18F-FDG
PET/CT SUVmax was 6.8 ±6.2. Diagnostic sensitivity of TCT was 83.6%, specificity 82.6%, accuracy 83.3% vs. 18F-FDG PET/CT sensitivity was 92.0%, specificity
66.7%, accuracy 87.8%. A significant correlation between Ki67 and SUVmax was
found in positive 18F-FDG PET/CT findings, unlike the correlation between Ki67
and Krenning score. Median PFS was 25 months (95% CI: 18.2–31.8), in 18F-FDG
PET/CT positive patients 23 months (95% CI: 16.3–29.7) and 18F-FDG PET/CT negative 26 months (p = 0.279). Progression-free survival predictors were SUVmax
and Krenning score.ConclusionsIn our study, TCT and 18F-FDG PET/CT have high diagnostic accuracy in detection of NET. Higher Krenning score on TCT and SUVmax in positive 18F-FDG PET/CT findings are predictors of disease progression. 99mTc-Tektrotyd scintigraphy and 18F-FDG PET/CT can be useful complementary tools
in management of patients with NETs and in predicting patients’ outcome.
A comparison of the risk factors of diabetic retinopathy between type 2 diabetes mellitus patients with and without metabolic syndrome
Authors: Lee Chao-Hsien , Tseng Peng-Lin , Chang Wei-Ting , Chen Yi-Chien , Chiu Tsai-Tung 
Published: March 2021

IntroductionThis study was aimed at analyzing, modeling, and comparing the risk factors of diabetic retinopathy (DR) among type 2 diabetes mellitus (DM) patients with and without metabolic syndrome (MS).Material and methodsA cross-sectional study from July 2017 to July 2019 was performed by tracing type 2 DM patients who received treatment at an out-patient clinic and a mydriatic examination by an ophthalmologist in a single institute in south Taiwan. A total of 802 patients without DR were recruited and divided into two groups based on whether they had MS for this study. We analyzed the impact of DR based on the potential and related factors of these two groups.ResultsThe sample consisted of 802 patients; 282 patients did not have MS, and 520 did. A comparison of the risk factors of DR among the patients with and without MS revealed that the level of glycated hemoglobin (HbA1c) was a co-risk factor of DR. However, female sex, betel quid chewing, family history of DM, and higher total cholesterol were found to be risk factors of DR among the patients who had MS. Betel quid chewing, especially, could exacerbate the disease condition of DM and elevate the risk of DR.ConclusionsOf those risk factors, betel quid chewing may be the main reason for DM deterioration and raised risk of DR. Hence, we recommend that the chewing of betel quid should be avoided to prevent DR.
Ox-low density lipoprotein (ox-LDL) increased the susceptibility of primary nephrotic syndrome (PNS) by regulating the Treg/Th17 ratio via the MEG3 signaling
Authors: Jin Li , Wang Xiaopei , Xie Xinfang , Lan Ping , Yang Shifeng 
Published: March 2021

IntroductionPatients with primary nephrotic syndrome (PNS) were reported to exhibit the evident imbalance between the number of Th17 and Treg cells in their peripheral blood monocytes (PBMCs), which might be the immunological basis of the disease.Material and methods40 PNS patients and 42 healthy individuals were recruited in this study. FCM assay was used to observe the levels of Treg and Th17 cells.ResultsThe Treg/Th17 ratio was evidently decreased in PNS patients. The levels of MEG3 and RORγt were increased in the PNS group, while the levels of miR-17, miR-125a and FOXP3 mRNA were reduced in the PNS group. Moreover, the levels of IL-6 and IL-1β were highly increased in PNS patients. Ox-low density lipoprotein (ox-LDL) treatment significantly increased the levels of MEG3 and RORγt mRNA/protein while decreasing the levels of miR-17, miR-125a, and FOXP3 mRNA/protein in THP-1 cells, and the transfection of MEG3 siRNA partly alleviated the dysregulation in the expression of MEG3, relevant miRNAs and relevant mRNAs induced by ox-LDL. Also, the expression of miR-17 and miR-125a was evidently decreased upon the successful transfection of MEG3, but the RORγt mRNA/protein levels were promoted while the FOXP3 mRNA/protein levels were inhibited.ConclusionsOur results demonstrated that ox-LDL could promote the inflammatory response of PNS by decreasing the Treg/Th17 ratio via activating the MEG3 signaling. The activation of MEG3/miR-125a/FOXP3 axis and MEG3/miR-17/RORγt axis respectively lead to the Treg/Th17 imbalance, which resulted in up-regulated IL-6 and IL-1β levels, thus increasing the susceptibility of PNS.