bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Impact Assessment of Beach Wrack and Litter on Beach Ecosystem Services to Support Coastal Management at the Baltic Sea
Authors: Robbe Esther , Woelfel Jana , Balčiūnas Arūnas , Schernewski Gerald 
Published: September 2021

AbstractAs accumulation zones, sandy beaches are temporal sinks for beach wrack and litter, both often seen as nuisances to tourists. Consequently, there is a need for beach management and an enhanced political interest to evaluate their ecosystem services. We applied a new online multidisciplinary assessment approach differentiating between the provision, potential, and flow at German and Lithuanian beaches (Southern Baltic Sea). We selected a set of services and assessed four beach scenarios developed accordingly to common management measures (different beach wrack and litter accumulations). We conducted comparative assessments involving 39 external experts using spread-sheets and workshops, an online survey as well as a combined data-based approach. Results indicated the relative importance of cultural (52.2%), regulating and maintenance (37.4%), and provisioning services (10.4%). Assessed impact scores showed that the removal of beach wrack is not favorable with regard to the overall ecosystem service provision. Contrarily, the removal of litter can increase the service flow significantly. When removing beach wrack, synergies between services should be used, i.e., use of biomass as material or further processing. However, trade-offs prevail between cultural services and the overall provision of beach ecosystem services (i.e., coastal protection and biodiversity). We recommend developing new and innovative beach cleaning techniques and procedures, i.e., different spatio-temporal patterns, e.g., mechanical vs. manually, daily vs. on-demand, whole beach width vs. patches. Our fast and easy-to-apply assessment approach can support decision-making processes within sustainable coastal management allowing us to show and compare the impacts of measures from a holistic ecosystem services perspective.
10-year follow-up of the Columbus knee prostheses system in a prospective multicenter study
Authors: Fuchs Andreas , Häussermann Philip , Hömig Dirk , Ochs Björn Gunnar , Klopfer Tim , Müller Christof A. , Helwig Peter , Konstantinidis Lukas 
Published: September 2021

Abstract
Introduction
As endpoint of a prospective multicenter 10-year documentation using the Columbus system, this evaluation carried out results of clinical scores (Knee Society Score and Oxford Knee Score), an evaluation of radiological imaging, survival rates and a collection of complication statistics.

Materials and methods
There was a multicenter prospective recruitment of consecutive patients with the indication for total knee replacement (TKR). Preoperatively and 10 years after implantation, clinical scores, range of motion and radiological imaging was performed. During this period, a detailed documentation of complications was made.

Results
A total of 210 patients were recruited in 5 centers. 140 patients were available for endpoint examination 10 years after surgery. A survival rate of 96.6% (CI 95%) for the implanted Columbus prostheses after 10 years was demonstrated. Cumulative KSS showed an improvement of 75.3 (± 38.1) points and was highly significant (p < 0.0001, t test). The average functional improvement in the Oxford score was 20.6 (± 9.5) points and was also highly significant (p < 0.0001). The ROM improved from 106.5° (± 20.5) preoperatively to 116.0° (± 11.5) (p < 0.0001, t test). There were no implant-related complications as well as no new complication documented between 5- and 10-year follow-up.

Conclusions
The endpoint analysis after an observation period of 10 years provided good clinical and radiographic results. In particular, an excellent survival rate of 96.6% after 10 years was demonstrated. The data published in this study are the first to be available in a prospective multicenter study on this system, which leads to a high level of clinical significance.
Macular, papillary and peripapillary perfusion densities measured with optical coherence tomography angiography in primary open angle glaucoma and pseudoexfoliation glaucoma
Authors: Cornelius Anna , Pilger Daniel , Riechardt Aline , Reitemeyer Emanuel , Rübsam Anne , Winterhalter Sibylle , Maier Anna-Karina B. 
Published: September 2021

Abstract
Purpose
To compare the blood flow situation in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG) using optical coherence tomography angiography (OCTA).

Methods
In this prospective study a total of 26 POAG and 23 PXG eyes were included. All patients underwent a complete ophthalmological examination including standard automated perimetry, stereoscopic photographs of the optic disc, peripapillary retinal nerve fibre layer analysis and examination of vascular parameters of the optic nerve head (ONH), the peripapillary region and macula using OCTA. In addition to the vascular parameters recorded by the device, the vascular images were graphically evaluated using Image J. All recorded vascular parameters were compared between both groups and correlated to structural and functional parameters.

Results
The mean superficial perifoveal plexus perfusion density (PD) was significantly lower in PXG eyes than compared to POAG eyes using OCTA (32.57% ± 3.57% vs. 34.92% ± 2.11%, p = 0.007). The mean PD parameters for the superficial peripapillary plexus (40.98% ± 3.04% vs. 42.09% ± 2.29%, p = 0.152) as well as the size of the foveal avascular zone (FAZ) (0.23 mm2 ± 0.1 mm2 vs. 0.23 mm2 ± 0.09 mm2) did not differ between both groups. Additional graphic evaluation using Image J showed no significant difference for superficial perifoveal plexus PD (32.97% ± 1.11% vs. 33.35% ± 0.95%, p = 0.194) and peripapillary plexus PD (46.65% ± 0.83% vs. 46.95% ± 0.5%, p = 0.127) between the groups. Retinal nerve fibre layer (RNFL) thickness correlated significantly with peripapillary plexus PD for both OCTA data and Image J data (p < 0.001, p = 0.032).

Conclusion
The severity of the glaucoma seems to be crucial for peripapillary and macular perfusion densities, and not the form of glaucoma. An additional graphic evaluation is a possible step that could be implemented to improve the comparability of OCTA scans and to optimize the possibility of quantitative perfusion analysis in the case of deviating quality criteria.
Predictors for thromboembolism in patients with cholangiocarcinoma
Authors: Pfrepper Christian , Knödler Maren , Schorling Ruth Maria , Seehofer Daniel , Petros Sirak , Lordick Florian 
Published: September 2021

Abstract
Background
Patients with cancer are at increased risk of thromboembolic events contributing significantly to cancer-related morbidity and mortality. Because cholangiocarcinoma is a rare type of cancer, the incidence of thromboembolism in this patient population is not well defined.

Methods
Patients with cholangiocarcinoma treated at the University Cancer Center Leipzig between January 2014 and December 2018 were analyzed retrospectively regarding the incidence of arterial and venous thromboembolism.

Results
A total of 133 newly and consecutively diagnosed patients were included, of whom 22% had stage IV disease. Thromboembolism was diagnosed in 39 (29.3%), with 48% of the events occurring between 60 days prior and 30 days after the initial diagnosis. Arterial thrombosis accounted for 19% and portal venous thrombosis for 33% of the events, while the rest of events occurred in the non-portal venous system. In multivariable analysis, an ONKOTEV score ≥ 2 was the only independent predictor for thromboembolism. Serum CA 19-9 was available in 87 patients (65.4%). In this subgroup, CA 19-9 above the median of 97.7 U/ml and vascular or lymphatic compression were independent predictors for thromboembolism in the first year and CA 19-9 alone remained a significant predictor over the whole observation period. An ONKOTEV score ≥ 2 and increasing age were predictors of survival.

Conclusions
A very high thromboembolic risk was observed in cholangiocarcinoma, comparable to the risk situation in pancreatic and gastric cancer. The ONKOTEV score and serum CA 19-9 are independent predictors of thromboembolic events. Prospective validation of our observations in this patient population is warranted.
Surface-based nocturnal air temperature inversions in southern Poland and their influence on PM10 and PM2.5 concentrations in Upper Silesia
Authors: Niedźwiedź Tadeusz , Łupikasza Ewa Bożena , Małarzewski Łukasz , Budzik Tomasz 
Published: September 2021

AbstractThe frequency, strength and seasonal variations of surface-based temperature inversions (SBTIs) in Upper Silesia (Southern Poland) were examined using data from January 2001 to September 2020. Based on the air temperatures recorded at the meteorological station of the Institute of Earth Sciences in Sosnowiec (263 m a.s.l.) at heights of 2 m and 88 m above the ground, the vertical temperature gradient of the 100-m layer (γSos100 m) was determined. A lapse rate of γSos100 m > 0.5 K was defined as a temperature inversion. The measurements for 00 UTC (midnight) and 12 UTC (midday) were compared with data from the upper air station in Wrocław (116 m a.s.l.) located in the Lower Silesia Lowland, approximately 170 km NW of Sosnowiec. Based on soundings from Wrocław, in addition to the temperature gradient in the lower 100-m layer of air (γWrc100), three other characteristics of SBTIs were calculated: inversion depth (ID) or thickness in metres, inversion strength (ΔTi) in K and vertical temperature gradients across the whole SBTI layer γi in K 100 m−1. On an annual basis, the frequency of nighttime SBTIs (γ > 0.5 K 100 m−1) ranged from 47% in Sosnowiec to almost 59% in Wrocław. At both stations, the fewest SBTIs occurred in winter (23–38%) and the most in summer (64–75%). Moreover, they were more frequent in spring (52–61%) than in autumn (49–59%). The SBTI frequency was very low during the midday hours, amounting to 0.6–0.7% days a year, and it increased to 1–2% only in winter. Annually, the depth of 81% of inversions ranged between 50 and 300 m, varying seasonally from almost 67% in winter to 87% in summer. The presented research shows that SBTIs in winter were among the main factors contributing to a high concentration of particulate matter pollutants in the ground-level atmosphere. During nights with temperature inversions, the annual mean PM10 concentration reached 125% of the mean value, ranging from 114% in summer to 189% in winter.
Lifestyle factors in patients with rheumatoid arthritis—a cross-sectional study on two Scandinavian cohorts
Authors: Karstensen Julie Katrine , Primdahl Jette , Andersson Maria L. E. , Christensen Jeanette Reffstrup , Bremander Ann 
Published: September 2021

Abstract

Introduction
The risk for cardiovascular diseases and other comorbidities increases with the number of unhealthy lifestyle factors in the general population. However, information on the combined number of unhealthy lifestyle factors in people with rheumatoid arthritis (RA) is scarce.

Objectives
To study lifestyle factors and the association between disease impact and two or more unhealthy lifestyle factors in two Scandinavian cohorts with RA.

Methods
We analysed data from two cohorts, Danish (n = 566; mean age 61.82 (SD 11.13) years; 72% women) and Swedish (n = 955; mean age 66.38 (SD 12.90) years; 73% women). Lifestyle factors (tobacco use, BMI, alcohol consumption and physical activity) were dichotomised as healthy vs. unhealthy (range 0–4 unhealthy factors). The association between disease impact and two or more unhealthy lifestyle factors was analysed using logistic regression.

Results
Sixty-six percent of Danish and 47% of Swedish respondents reported two or more unhealthy lifestyle factors, most commonly, being overweight/obese and physical inactivity. For Danish participants, two or more unhealthy lifestyle factors were associated with (OR and 95% CI) male gender (1.86; 1.21–2.85), cardiovascular diseases (1.90; 1.28–2.82) and disease duration (0.97; 0.95–0.99). Corresponding findings for the Swedish cohort were male gender (1.42; 1.07–1.89), pain (1.10; 1.04–1.15), fatigue (1.09; 1.04–1.15), physical functioning (1.64; 1.28–2.10) and quality of life (0.35; 0.20–0.60).

Conclusion
Many patients, most often male, in both cohorts had two or more unhealthy lifestyle factors. The number of unhealthy lifestyle factors indicates a multifaceted relationship with disease impact.

Key Points• This article contributes with new information concerning the proportion of patients with RA who have one or more unhealthy lifestyle factors.• Every second patient in the two included cohorts reported two or more unhealthy lifestyle factors.• Two or more unhealthy lifestyle factors were more common in men than in women but were not necessarily associated with measures of disease impact.• In order to adhere to a healthier lifestyle, a large proportion of the patients need to change more than one lifestyle habit, which entails a challenge for both the patients and the health professionals.
To what extent are pollutant emission intensified by international tourist arrivals? Starling evidence from G7 Countries
Authors: Gyamfi Bright Akwasi , Bein Murad A. , Adedoyin Festus Fatai , Bekun Festus Victor 
Published: September 2021

AbstractA large volume of environmental science and pollution research has focused on the contributions of various forms of energy consumption to emissions. However, little attention is given to the impact of human activities such as tourism. Hence, this study investigates the impact of tourist arrivals, energy use, and economic growth on CO2 emissions in the G7 countries for the period 1995–2018. The study employed the use of dynamic panel estimations, namely dynamic ordinary least square, fully modified ordinary least squares and panel pooled mean group-autoregressive distributed lag model (PMG-ARDL) estimation techniques to establish long-run and short-run relationships between the study variable of interest, while the Dumitrescu Hurlin non-causality test was used to test for causality direction among the variables outlined. Empirical findings from the regression revealed that economic growth, tourism and energy use are strong drivers of emission levels in the G7 bloc, while the causality analysis revealed that there is unidirectional causality from CO2 to energy use, CO2 to economic growth (GDP) and GDP to tourist arrivals. These outcomes imply that tourism, energy use and economic growth have no direct effect on emissions, but rather emissions predict economic growth and energy use. Furthermore, tourist arrivals predict energy use; economic growth predicts tourism. Overall based on the study of empirical outcomes, we suggest that to achieve more significant results in reducing emissions, governments of the G7 countries should continue to emphasize green tourism as well as increase the share of renewable energy in their regional energy mix. More policy direction was outlined in the concluding section of this study.
Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder
Authors: Casey S. , Carter M. , Looney A. M. , Livingstone V. , Moloney G. , O’Keeffe G. W. , Taylor R. S. , Kenny L. C. , McCarthy F. P. , McCowan L. M. E. , Thompson J. M. D. , Murray D. M. ,   the SCOPE Consortium
Published: September 2021

AbstractAutism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment.
Microstructure–property relation and machine learning prediction of hole expansion capacity of high-strength steels
Authors: Li Wei , Vittorietti Martina , Jongbloed Geurt , Sietsma Jilt 
Published: September 2021

Abstract
The relationship between microstructure features and mechanical properties plays an important role in the design of materials and improvement of properties. Hole expansion capacity plays a fundamental role in defining the formability of metal sheets. Due to the complexity of the experimental procedure of testing hole expansion capacity, where many influencing factors contribute to the resulting values, the relationship between microstructure features and hole expansion capacity and the complexity of this relation is not yet fully understood. In the present study, an experimental dataset containing the phase constituents of 55 microstructures as well as corresponding properties, such as hole expansion capacity and yield strength, is collected from the literature. Statistical analysis of these data is conducted with the focus on hole expansion capacity in relation to individual phases, combinations of phases and number of phases. In addition, different machine learning methods contribute to the prediction of hole expansion capacity based on both phase fractions and chemical content. Deep learning gives the best prediction accuracy of hole expansion capacity based on phase fractions and chemical composition. Meanwhile, the influence of different microstructure features on hole expansion capacity is revealed.

Graphical abstract
Performance optimization of RSOA based mm-wave radio-over-fibre access network
Authors: Udvary Eszter 
Published: September 2021

AbstractIn this paper, a Reflective Semiconductor Optical Amplifier based, Radio-over-Fibre access network configuration has been proposed to feed future millimeter-wave radio systems. The system architecture combines several approaches to overcome the challenges of millimeter-wave signal transmission. Reflective semiconductor optical amplifier modulator realizes a colorless and relatively cost-effective Remote Antenna Unit. The same optical carrier is used for both downlink and uplink. Optical single-sideband modulation is used at the downlink, which is robust against chromatic dispersion, but the complex realization of this modulation format is not possible at the Remote Antenna Unit. Optical intermediate frequency transmission is applied at the uplink direction, and the required local oscillator signal originates from the central station. The critical element is the reflective optical amplifier, as it compensates for the optical loss and works as an external intensity modulator. The operation of the reflective optical amplifier is modeled by multisection rate and wave equation-based description. The amplification and modulation behaviors of an available reflective optical amplifier are also measured. The experimental work validated the colorless operation and the quality of the modulation versus bias current and input optical power. Finally, system simulation was realized. The uplink and downlink power budgets were balanced, and optimal values for the optical coupling rate and RSOA bias current have been selected.
Quantum k-community detection: algorithm proposals and cross-architectural evaluation
Authors: Gemeinhardt Felix G. , Wille Robert , Wimmer Manuel 
Published: September 2021

AbstractEmerging quantum technologies represent a promising alternative for solving hard combinatorial problems in the post-Moore’s law era. For practical purposes, however, the current number of qubits limits the direct applicability to larger real-world instances in the near-term future. Therefore, a promising strategy to overcome this issue is represented by hybrid quantum classical algorithms which leverage classical as well as quantum devices. One prominent example of a hard computational problem is the community detection problem: a partition of a graph into distinct communities such that the ratio between intra-community and inter-community connectivity is maximized. In this paper, we explore the current potential of quantum annealing and gate-based quantum technologies to solve the community detection problem for an arbitrary number of communities. For this purpose, existing algorithms are (re-)implemented and new hybrid algorithms, that can be run on gate-model devices, are proposed. Their performance on standardized benchmark graphs has been evaluated and compared to the one of a state-of-the-art classical heuristic algorithm. Although no quantum speed-up has been achieved, the existing quantum annealing-based methods as well as the novel hybrid algorithms for gate-based quantum computers yield modularity values, which are similar to those of the classical heuristic. However, the modular architecture of the used algorithms allows for fast utilization of more powerful quantum technologies once they become available.Reproducibility:Our code and data are publicly available (Github in Quantum Modularization.https://github.com/jku-win se/quantum_modularization2021).
Conductivity measurement of ionic liquids confined in the nanopores of metal–organic frameworks: a case study for [BMIM][TFSI] in HKUST-1
Authors: Zhang Zejun , Li Chun , Chandresh Abhinav , Heinke Lars 
Published: September 2021

AbstractNanoporous materials like metal–organic frameworks (MOFs) attract considerable attention as porous host for electrolytes like ionic liquids (ILs). The conductivity and mobility of the ions in the pores are among the key properties and their experimental quantification is of paramount importance. Here, three different approaches for the quantification of the ion conductivity of IL@MOF via electrochemical impedance spectroscopy (EIS) are compared: the material in the form of IL-impregnated MOF powders pressed into pellets between two planar electrodes, MOF films grown on substrates with deposited electrodes loaded with IL by impregnation, and the IL-loaded MOF films where excess IL is removed. Contact-angle measurements and EIS data show that the excess IL on the outer MOF surface of the film or pellet results in apparent conductivities, larger than the intrinsic conductivity of the IL@MOF. Removing the excess IL enables the experimental quantification of the intrinsic IL@MOF conductivity.
Graphical abstract
The ionic conduction of ionic liquid (IL) confined in nanoporous metal–organic framework (MOF) is explored via impedance spectroscopy, where the material is either in the form of pellets pressed from powder or in the form of thin films grown on suitable substrates. The different methods show substantially different results, attributed to excess IL on the external surface, and a method for recording the intrinsic IL@MOF conductivity is presented.