bluuebunny/crossref_metadata_2025_split huggingface dataset:
Availability and Service Provision of Multidisciplinary Diabetes Foot Units in Australia: A Cross-Sectional Survey.
Authors: Vo Uyen Giao , Gilfillan Molly , Hamilton Emma Jane , Manning Laurens , Munshi Bijit , Hiew Jonathan , Norman Paul Edward , Ritter Jens Carsten 
Published: February 2021

Abstract
Background: With growing global prevalence of diabetes mellitus, diabetes-related foot disease (DFD) is contributing significantly to disease burden. As more healthcare resources are being dedicated to the management of DFD, service design and delivery is being scrutinised. Through a national survey, this study aims to investigate the current characteristics of services which treat patients with DFD in Australia.Methods: An online survey was distributed to all 195 Australian members of the Australian and New Zealand Society for Vascular Surgery investigating aspects of DFD management in each member’s institution.Results: From the survey, 52 responses were received (26.7%). A multidisciplinary diabetes foot unit (MDFU) was available in more than half of respondent’s institutions, most of which were tertiary hospitals. The common components of MDFU were identified as podiatrists, endocrinologists, vascular surgeons and infectious disease physicians. Majority of respondents (84.3%) identified vascular surgery as being the primary admitting specialty for DFD patients that require hospitalisation. This finding was consistent even in centres with MDFU clinics. Less than 20% of MDFUs had independent admission rights.Conclusions: Most tertiary centres in Australia provide their diabetic foot service in a multidisciplinary environment however their composition and function remain heterogeneous. The findings of this study provide an opportunity to evaluate current practice and, to initiate strategies aimed to improve outcomes of patients with DFD.
Methodology Proposal of ADHD Classification of Children Based on Cross Recurrence Plots
Authors: Aceves-Fernandez Marco 
Published: February 2021

Abstract
Dealing with electroencephalogram signals (EEG) are often not easy. The lack of predicability and complexity of such non-stationary, noisy and high dimensional signals is challenging. Cross Recurrence Plots (CRP) have been used extensively to deal with detecting subtle changes in signals even when the noise is embedded in the signal. In this contribution, a total of 121 children performed visual attention experiments and a proposed methodology using CRP and a Welch Power Spectral Distribution have been used to classify then between those who have ADHD and the control group. Additional tools were presented to determine to which extent the proposed methodology is able to classify accurately and avoid misclassifications, thus demonstrating that this methodology is feasible to classify EEG signals from subjects with ADHD. Lastly, the results were compared with a baseline machine learning method to prove experimentally that this methodology is consistent and the results repeatable.
The Dermal Nipple-Areola-Complex Flap Method in Female-to-Male Gender Affirming Surgery
Authors: Bøkset Mari Irgens , Carstensen Lena Felicia , Jensen Jesper Poul Næsted 
Published: February 2021

Abstract
Background:Subcutaneous mastectomy (SCM) plays a major role in female-to-male (FtM) gender affirming surgery, and obtaining a flattering chest contour remains a challenge to the surgeon. We present an operative method using a dermal nipple-areola-complex (NAC) flap with the aim to create a naturally masculine appearance, while reducing the risk of NAC complications by maintaining sufficient neurovascularization.Methods:Through a horizontal incision, a superior thoracic full skin flap was elevated at the dissection plane for mastectomy. The mastectomy was continued inferiorly, creating an inferior flap including the NAC. The surface of the inferior flap was deepithelialized, secluding the NAC, which allowed the inferior dermal flap to be inserted posterior to the superior flap. A circular defect was created in the superior flap, into which the NAC was sutured.Results:The surgery delivered satisfactory results with an aesthetically pleasing masculine appearance and a high level of patient satisfaction. We were able to place the horizontal scars inferiorly along the pectoral muscles, which enabled some camouflage. Additionally, the inferior flap provided a uniform filling effect to the chest, further contributing to the male aesthetic. There were no NAC complications.Conclusion:The dermal NAC flap method could be applied as an excellent alternative to the traditionally performed free nipple graft technique in FtM gender confirming surgery. The method is simple, provides an aesthetically appealing outcome, and poses a low risk of NAC complications. Intraoperatively, it allows for good exposure and a uniform removal of breast tissue, as well as repositioning and/or reduction of the NAC where required.
ARID1A Upregulation Predicts Poor Survival in Patients with Liver Cancer
Authors: Jiang Feng , Wei Ke , Wang Ming , Wu Chuyan 
Published: February 2021

Abstract
Objective: ARID1A has been identified as a possible biomarker for certain cancers. There is, however, some debate regarding its function in liver cancer. Methods: Associations between clinical variables and ARID1A were evaluated. Cox and Kaplan – Meier analysis were used to examine clinicalopathological factors linked to overall survival of patients with liver cancer. Gene Set Enrichment Analysis (GSEA) was conducted using the dataset of the Cancer Genome Atlas. Results: High expression of ARID1A was correlated with the gender and tumor topography (T) diagnosis of liver cancer. Patients with elevated ARID1A expression had poorer prognosis than those with low ARID1A expression. The study also showed that ARID1A was an independent risk factor for overall survival. GSEA established pathways involved in ERBB signaling, cancer, insulin signaling, mTOR signaling, MAPK signaling, VEGF signaling, Ubiquitin signaling, and Wnt signaling as differentially enriched in ARID1A-high expression liver cancer. Conclusion: ARID1A has been shown to be expressed at high rates of liver cancer and to represent a possible independent molecular marker for diagnosis and prognosis of liver cancer.
Delayed Pancreatic Fistula: An Unaccustomed Complication Following Pancreaticoduodenectomy.
Authors: Jena Suvendu Sekhar , Meher Dibyasingh , Ranjan Rahul 
Published: February 2021

Abstract
BackgroundPost-operative pancreatic fistula is a morbid complication after pancreaticoduodenectomy. Though most of them present in the immediate post-operative period, few case reports have mentioned it even 7 years after index surgery. Here, we report a delayed presentation of pancreatic fistula 6 months after surgery.Case reportA 57 year old female underwent Whipple’s pancreaticoduodenectomy for pancreatic head adnocarcinoma and was discharged with an uneventful post-operative recovery. She presented after 6 months with complaints of abdominal pain and distension which upon evaluation found to be a pancreatic enzyme rich mutiloculated collection. It was managed with per-cutaneous drain placement.DiscussionPancreatic fistula remained a major cause of morbidity and mortality even after 100 years of its existence. It can be overt fistula which manifest in the immediate post-operative period or occult fistula which manifests long after primary surgery. Various causes of delayed fistula are anastomotic site stricture, previous chemotherapy, infection. The management options available are percutaneous drainage, endoscopic stenting of anastomotic stricture or redoing the anastomosis.ConclusionPancreatic fistula can have a delayed presentation which can be diagnosed and managed with regular follow up.
Predictive Value of Computed Tomography With Coronal Reconstruction in the Right Hemicolectomy With Complete Mesocolic Excision:A Retrospective Study.
Authors: Yu Hui , Zhuang Yong , Jian Jinliang , Yang Chunkang 
Published: February 2021

Abstract
Background:Understanding vascular anatomy is critical for performing central vascular ligation (CVL) in the right hemicolectomy with complete mesocolic excision (CME). This study was aimed to investigate the predictive value of multi-slice spiral computed tomography (MSCT) with coronal reconstruction in the right hemicolectomy. Methods:Eighty patients who underwent right hemicolectomy in our hospital were included. The intraoperative imaging data and the images of MSCT with coronal reconstruction were analyzed retrospectively. The detection rate of the ileocolic vein (ICV) and ileocolic artery (ICA) location and the accuracy of the preoperative prediction of their anatomical relationship were analyzed. The detection rate and preoperative prediction accuracy of the gastrocolic trunk of Henle (GTH), middle colic artery (MCA), and middle colin vein (MCV) were analyzed. The distance from the ICV root to the GTH root (ICV-GTH distance) was measured and analyzed. The maximum distance from the left edge of the superior mesenteric artery (SMA) to the right edge of the superior mesenteric vein (SMV), named “leSMA-reSMV distance,” was measured and analyzed too.Results:74 (92.5%) patients had been located both the ICV and ICA roots and determined the anatomical relationship between them by MSCT, of which 72 were confirmed by intraoperative findings，and the accuracy was 90% (72/80). GTH was located by MSCT in 75 (93.7%) patients, and the accuracy was 91.25% (73/80). MCA was located by MSCT in 47(58.75%) patients, and the accuracy was 46.25% (37/80). MCV was located by MSCT in 51 (63.75%)patients, and the accuracy was 53.75% (43/80). The ICV-GTH distance was measured in 73 (91.2%) patients, and the mean distance was 4.28±2.5cm. The leSMA-reSMV distance was measured in 76 (95%) patients, and the mean distance was 2.21±0.6cm. Conclusions:MSCT with coronary reconstruction can locate the roots of ICV, ICA, and GTH, predict the boundary of SMA and SMV, analyze the anatomical relationship between them, and estimate the location and range of central ligation region, which are of some predictive value in central vascular ligation in the right hemicolectomy with CME.
Finite Element Analysis and in Vitro Biomechanical Experiment on the Effect of Unilateral Partial Facetectomy Performed by Percutaneous Endoscopy on the Stability of Lumbar Spine
Authors: Li Xin-ru , Li Zi-tong , Nong Lu-ming 
Published: February 2021

Abstract
Purpose: To investigate the lumbar biomechanical effects of unilateral partial facetectomy (UPF) of different facet joint (FJ) portions under percutaneous endoscopy. Methods: A 3D finite element (FE) model of the lumbar spine and 40 fresh calf spine models were used to simulate UPF under a physiological load performed through 3 commonly used needle insertion points (IPs) : (1) The apex of the superior FJ (as the first IP), (2) The midpoint of the ventral side of the superior FJ (as the second IP), (3) The lowest point of the ventral side of the superior FJ (as the third IP). The range of motion (ROM) and the L4/5 intradiscal maximum pressure (IMP) were measured and analyzed under a physiological load in all models during flexion, extension, left-right lateral flexion, and left-right axial rotation. Results: When UPF was performed through the first and the third IPs, the ROM of the lumbar spine and the L4/5 IMP in the FE model were significantly increased compared with those in the intact FE model. When UPF was performed through the second IP, the ROM of the lumbar spine and the L4/5 IMP were not significantly different compared with those in the intact FE model. When UPF was performed through the second IP, the ROM of the lumbar spine and the L4/5 IMP in the calf spine models were not statistically different from the intact calf spine model. Conclusion: UPF through the second IP resulted in a minimal impact on the biomechanics of the lumbar spine. Thus, it might be considered as the most appropriate IP for UPF.
Modified Firefly Algorithm for Optimizing Biomedical Breast Cancer Queries
Authors: Ramalingam Gomathi 
Published: February 2021

Abstract
Querying and retrieving Semantic Web data is a challenging task due to the increment in its volume. Many query languages were designed to retrieve Semantic Web data. A popular querying method of communication in Semantic Web is SPARQL. The query languages were designed with some optimization strategies, and it was found in literature that these query languages were not able to handle large volume of data efficiently. In this research, a Modified Firefly Algorithm (MFA) is applied to optimize the SPARQL queries so that it can retrieve data from a large Semantic Web repository efficiently by reducing query execution time. Every query will have multiple query plans generated with different cost values. The challenge is to choose the best query plan which reduces the query cost and query execution time. The proposed algorithm uses the best query plan in the previous iteration to calculate the distance between two query plans using the radius parameter. The proposed algorithm generates a query plan which is a global optimal solution. MFA is evaluated using the BioPortal dataset with triples containing breast cancer. Experimental analysis is conducted to identify the significant improvement in performance of the proposed work with the existing nature inspired query optimization algorithms. The efficiency of MFA is compared with other algorithms in terms of query execution time and the performance is evaluated.
Diagnostic Mystery — a Rare Right Ventricular Cardiac Hemangioma: a Case Report
Authors: Fan Jingya , Guo Lei , Teng Peng , Dai Xiaoyi , Zheng Qi , Wu Shengjun , Ni Yiming 
Published: February 2021

Abstract
Background: Cardiac hemangiomas are rare in all kinds of benign cardiac tumors. Although cardiac hemangiomas affect all ages and may occur anywhere within the heart, right ventricular hemangiomas are extremely uncommon.Case presentation: We report a 56-year-old woman presented with chest tightness and breath shortness for 3 months. Transthoracic echocardiography and coronary computed tomography angiography showed a mass located adjacent to the apex of the right ventricle but both failed to figure out where the mass originated from, remaining a diagnostic mystery preoperatively. The mass was removed successfully and the histopathological examination confirmed it was hemangioma.Conclusions: Cardiac magnetic resonance should be the ultimate diagnostic tool of cardiac tumors. Surgical removal, associated with a low recurrence rate and long-term survival benefits, should be the first choice of therapy for cardiac hemangiomas.
PROLIFERATE: An adaptable framework to evaluate participatory research products
Authors: Plaza Maria Alejandra Pinero de , Archibald Mandy , Lawless Michael , Ambagtsheer Rachel , Mudd Alexandra , McMillan Penelope , Kitson Alison 
Published: February 2021

Abstract
Background: Participatory research (PR) – the practice of involving stakeholders in research processes – is growing in prominence in health research because it can enhance the impact of research and the translation of research-based knowledge. Yet, the literature indicates that the products of PR studies are rarely evaluated empirically to track, demonstrate, and expand their claimed effectiveness and impact. This lack of measurement tools and frameworks can limit the effectiveness of knowledge translation (KT). Methods: We introduce a framework for evaluating the products of PR called PROLIFERATE. We use an inductive combination of formative and summative evaluation methods to pilot test the framework on a Frailty PR communication product (a video) to determine the methods’ functionality.Results: PROLIFERATE demonstrates adeptness for evaluating barriers and enablers of PR product uptake, effectiveness, and impact. It can identify ways to address barriers by assessing knowledge user perspectives on the comprehensibility of the product, emotional resonance, motivation to change, and future accessibility. Conclusions: PROLIFERATE can enable longitudinal and cross-sectional measurement of PR products in implementation and integrated KT efforts. It can evaluate and track the effectiveness and impact of different types of PR products in a situational responsive manner which compares users, platforms, and other factors in a replicable way.
Identification of novel drug candidates for treating tongue squamous cell carcinoma using computational approaches
Authors: Li Yinghua , Chen Zihao , Chen Lu , Li Weizhong 
Published: February 2021

Abstract
BackgroundTongue squamous cell carcinoma (TSCC) is one of the most common oral squamous cell carcinoma (OSCC) with a high occurrence and a poor prognosis, yet its molecular mechanisms are largely unknown and novel drug candidates are needed. The purpose of this study was to construct gene co-expression networks to identify hub proteins significantly associated with tumor grades and the overall survival (OS) of TSCC patients and provide potential drug candidates. MethodsThe mRNA-sequencing and clinical data were obtained from The Cancer Genome Atlas (TCGA) dataset. Weighted gene co-expression network analysis (WGCNA) was used for identifying the co-expression module related to the tumor grade of TSCC. The hub proteins were selected by the interaction number with other proteins, and their correlations with prognosis and tumor grades were calculated. Virtual screening of compounds by the hub protein structures was used to identify the drug candidates. ResultsWGCNA identified ten co-expression modules, in which the brown module consisted of 163 genes was most significantly correlated with the tumor grade. Six hub genes/proteins (BUB1, CCNB2, CDC6, CDC20, CDK1, and MCM2) tended to be in the central hub of the network. And higher expression levels of these hub genes were associated with tumor grades and worse overall survival. Three compounds, targeting hub proteins, demonstrated high binding affinities, favorable pharmacologic properties, and low toxicity. Conclusion The gene co-expression network-based study could provide additional insight into tumorigenesis and progression of TSCC, and our study might provide novel drug candidates.
Triple-wavelength filter based on the nanoplasmonic metal-insulator-metal waveguides
Authors: Truong Cao Dung , Van Tai Nguyen , Trinh Minh Tuan , Manh Hoang Chu , Tan Hung Nguyen , Hoai Bac Dang 
Published: February 2021

Abstract
In this paper, we present a proposal for compact photonic wavelength filtering and 3-dB wavelength splitting device based on nanoplasmonic metal-insulator-metal structure. The working performance of the device has been accurately simulated using the temporal coupled-mode theory. We use a numerical simulation method of eigenmode expansion propagation for the overall design process. We show that the transmission efficiency of the drop filter can be significantly enhanced by applying specifically optimization of nanostub waveguide. The proposed structure has potential applications in highly efficient ultra-compact integration circuits as well as in optical communication systems at nanoscale.
Feasibility and Diagnostic Reliability of Quantitative Flow Ratio in the Assessment of Non-Culprit Lesions in Acute Coronary Syndrome
Authors: Erbay Aslihan , Penzel Lisa , Abdelwahed Youssef Salah , Klotsche Jens , Schatz Anne-Sophie , Steiner Julia , Haghikia Arash , Landmesser Ulf , Stähli Barbara Elisabeth , Leistner David Manuel 
Published: February 2021

Abstract
Purpose
Several studies have demonstrated the feasibility and safety of hemodynamic assessment of non-culprit coronary arteries in setting of acute coronary syndromes (ACS) using fractional flow reserve (FFR) measurements. Quantitative flow ratio (QFR), recently introduced as angiography-based fast FFR computation, has been validated with good agreement and diagnostic performance with FFR in chronic coronary syndromes. The aim of this study was to assess the feasibility and diagnostic reliability of QFR assessment during primary PC.
Methods
A total of 321 patients with ACS and multivessel disease, who underwent primary PCI and were planned for staged PCI of at least one non-culprit lesion were enrolled in the analysis. Within this patient cohort, serial post-hoc QFR analyses of 513 non-culprit vessels were performed.
Results
The median time interval between primary and staged PCI was 49 [42–58] days. QFR in non-culprit coronary arteries did not change between acute and staged measurements (0.86 vs 0.87, p = 0.114), with strong correlation (r = 0.94, p≤0.001) and good agreement (mean difference − 0.008, 95%CI -0.013-0.003) between measurements. Importantly, QFR as assessed at index procedure had sensitivity of 95.02%, specificity of 93.59% and diagnostic accuracy of 94.15% in prediction of QFR ≤ 0.80 at the time of staged PCI.
Conclusions
The present study for the first time confirmed the feasibility and diagnostic accuracy of non-culprit coronary artery QFR during primary PCI. These results support QFR as valuable tool in patients with ACS to detect further hemodynamic relevant lesions with excellent diagnostic performance and therefore to guide further revascularisation therapy.
Plasmonic switch Based on asymmetric cavities with embedding square of gold inside the cavities
Authors: Ghadrdan Majid , Shahraki Mojtaba , Mansouri-Birjandi Mohammad Ali 
Published: February 2021

Abstract
In this paper, we proposed an all-optical plasmonic switch based on metal-insulator-metal (MIM) structures. We used the intrinsic nonlinear properties of gold to implement the switch. The proposed switch consists of a bus waveguide side coupled with a pair of asymmetric vertical cavities. We obtained the transmission spectrum of the structure for low input intensities. The results showed that a sharp dip occurs at the wavelength of 860 nm. Due to the nonlinear properties of gold and the nonlinear Kerr effects, the proposed switch has a high transmission ratio of about 0.8 and a low threshold power of 0.07 mW/µm2. The threshold power of the structure with and without using the gold nanostructure shows a reduction of 50%. The result showed that the proposed switch has the potentiality to be applied in the plasmonic integration circuits.
Going Virtual: Youth Attitudes Toward and Experiences of Virtual Mental Health and Substance use Services During the COVID-19 Pandemic
Authors: Hawke Lisa D , Sheikhan Natasha Y , MacCon Karen , Henderson Joanna 
Published: February 2021

Abstract
Background. During the COVID-19 pandemic, youth mental health and substance use services rapidly moved to virtual modalities to meet social distancing requirements. It is important to understand youth attitudes toward and experience of virtual services. Objective. This study examined the attitudes toward and experiences for virtual mental health and substance use services among youth drawn from clinical and non-clinical samples.Method. 409 youth completed a survey including questions about their attitudes toward and experience of virtual services. The survey included quantitative and open-ended questions on virtual care, as well as a mental health and substance use screener. Results. The majority of youth with mental health or substance use challenges would be willing to consider individual virtual services, but fewer would consider group virtual services. However, many have not received virtual services. Youth are interested in accessing a wide variety of virtual services and other supportive wellness services. Advantages and disadvantages of virtual services are discussed, including accessibility benefits and technological barriers. Discussion. As youth mental health and substance use services have rapidly gone virtual during the COVID-19 pandemic, it is essential that we hear the perspectives of youth to promote service utilization among those in need. Diverse, accessible, technologically stable virtual services are required to meet the needs of different youth, possibly with in-person options for some youth. Future research, engaging youth in the research process, is needed to evaluate the efficacy of virtual services to plan for sustainability of some virtual service gains beyond the pandemic period.