bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with in-stent stenosis after cerebral aneurysm embolization using a Pipeline embolization device
Authors: Flores-Milan Gabriel , Pressman Elliot , Peto Ivo , Ren Zeguang , Guerrero Waldo R. , Mokin Maxim 
Published: December 2021

Background Flow-diverting (FD) stents, with or without coiling, are a mainstay in endovascular treatment of intracranial aneurysms (IAs). One observed complication from flow diverter stent (FDS) insertion has been in-stent stenosis. Though previously studied in the short-term period, the long-term history of this complication has yet to be described. Methods We performed a retrospective cohort study of consecutive IAs treated with Pipeline Embolization Device (PED), with or without coiling, at our centre between September 2014 and December 2018 that had at least one digital subtraction angiogram (DSA) during follow-up. In-stent stenosis was measured from DSA images, and associated patient and procedural characteristics were analysed. Results 94 patients treated with PED for IA were identified. On initial DSA during follow-up, 52 patients (55.3%) had in-stent stenosis within the PED. Of these 52 patients, 17 had a second DSA during follow-up. In this 2nd DSA, improvement and/or stable in-stent stenosis was seen 16 patients (94.1%). One patient in this group had worsening in-stent stenosis had a vertebrobasilar junction FD stent. Of the patients without in-stent stenosis on initial DSA, 15 had a second DSA during follow-up. Only one of these patients (6.7%) had new appearance of in-stent stenosis (measuring 5%). Multivariate analysis found statin use to be predictive of in-stent stenosis (p = 0.020, Odds ratio = 0.279 and 95% confidence interval = 0.095–0.821). Conclusions In-stent stenosis after FDS placement was seen in 53.2% of cases, which had between 1–50% of stenosis. 82.4% had resolution/improvement of their stenosis. Statin use was protective of in-stent stenosis.
Factors affecting the quality of work-life of nurses: a correlational study
Authors: Kheiri Marzieh , Gholizadeh Leila , Taghdisi Mohammad Hossein , Asghari Elnaz , Musavi Mitra , Mahdavi Nader , Ghaffari Samad 
Published: December 2021

Background Quality of work-life is an important factor in the recruitment and retention of the nursing workforce and their work productivity. Aims This study aimed to identify factors that affect the quality of work-life of nurses. Methods In this correlational study, 239 nurses employed in a tertiary teaching hospital in Iran completed the study questionnaires, including the quality of work-life questionnaire. The associations between potential independent variables and quality of work-life were examined using multivariate regression analysis. Results Participants were mostly women (80.33%) and within the age range of 30–45 years (71.54%). Working in other hospitals, having a second job and health information-seeking behaviours were significant predictors of quality of work-life, explaining 28.68% of the total variance in quality of work-life of nurses. Conclusions Improving working standards may prevent nurses from working extra hours or in different occupations. This, along with facilitating the health information-seeking behaviours of nurses, may help improve their quality of work-life by maintaining a better work-life balance and acquiring knowledge and skills that can help with effective management of work and life commitments.
UHMWPE suture induced pseudotumor following arthroscopic rotator cuff repair: A case report
Authors: Yamakado Kotaro 
Published: December 2021

UHMWPE suture shows excellent biocompatibility and complication associated with suture debris had not been described before in shoulder surgery. In this study, a case of a 38-year-old man with a wear debris pseudotumor mimicking osteochondromatosis in the subacromial bursa five years after arthroscopic rotator cuff repair using a composite braid suture (a polydioxanone core with a sleeve of UHMWPE) was presented. Histological examination confirmed the presence of suture fragments surrounded with the osteochondral layer without inflammatory reactions. The present study implies the potential risk of free fragmented remnants from the UHMWPE suture. Because of the silent nature of the histological response, a high index of suspicion should be necessary to disclose the chanciness of its use.
Is training doctors in medical certification effective? Evidence from a prospective study in the Philippines
Authors: Rebanal Jomilynn , Adair Tim , Mikkelsen Lene 
Published: December 2021

Background Correct certification of causes of death by physicians according to International Classification of Diseases (ICD) rules is essential to generate mortality statistics of the quality needed to guide public health policy debates and reliably monitor the impact of health interventions. Several efforts to train doctors have been undertaken in the Philippines to improve Medical Certification of Causes of Death (MCCOD). However, there is very little evidence about the long-term effects of training interventions for medical certification. Objective To test whether there were measurable long-term impacts of this large-scale training intervention for improving medical certification and reducing different types of certification errors. Method We assessed the quality of 2100 MCCOD completed before face-to-face training with those written by the same doctors 6 months after the training. An assessment tool was used to evaluate the quality of MCCOD. Results Less than 1% of the 2100 MCCOD assessed prior to the training were completely error-free, increasing to 19.2% 6 months after the training. On average, the number of errors per certificate fell from 2.2 pre-training to 1.3, six months after training. Importantly, there was a 38% decrease in writing ill-defined causes on the last line, which is particularly important for the policy utility of data. Conclusion Training doctors in correct medical certification can have a long-term impact on medical certification practices. Implications Shorter, more focused, trainings that address the most common medical certification errors could have an even greater impact on medical certification practices.
Blindness paving the path to the diagnosis of metastatic prostate carcinoma: A unique case presentation
Authors: Jain Aadhar , Nayan Anveshi , Patwardhan Sujata 
Published: December 2021

Background: Intracranial metastases from prostate adenocarcinoma are very unusual and typically occur late in the course of the disease, and initial presentation with symptomatic brain involvement, especially vision loss is very rare (with this being only the sixth such reported case to the best of our knowledge). The present case elucidates how a diagnosis was reached in such a scenario and the management provided. Case presentation: A 66-year-old gentleman presented with loss of vision and headache with no other ocular or neurological complaint. Computed tomography (CT) of his head revealed a destructive lesion involving the clivus and a space-occupying lesion (SOL) in occipito-parietal region. Detailed inquiry regarding the possible primary source of suspected the metastatic lesion revealed an increased frequency of urination, nocturia, and significant weight loss. His serum prostate-specific antigen (PSA) levels were raised. He was treated by surgical hormonal therapy and his visual symptoms improved. Conclusion: Awareness of such a presentation can lead to an accurate diagnosis. Initiation of appropriate therapy can successfully alleviate the neurologic deficits.
Biceps tenodesis combined with rotator cuff repair increases functional status and elbow strength
Authors: Ihsan Kilic Ali , Hapa Onur , Ozmanevra Ramadan , Demirhan Demirkiran Nihat , Gursan Onur 
Published: December 2021

Purpose The aim of the present study was to prospectively evaluate the elbow flexion and supination strengths and the functional outcomes of patients following arthroscopic rotator cuff repair combined with simultaneous biceps tenodesis. Methods 19 patients who underwent arthroscopic rotator cuff repair and biceps tenodesis with at least 24 months of follow-up were included. Patients were evaluated using a visual analog scale (VAS) for bicipital groove pain, American Shoulder and Elbow Surgeons (ASES), and constant scores (CS), biceps apex distance (BAD), elbow flexion, and supination strengths. Results The VAS for biceps groove measurement averages in the postoperative 6th, 12th, and 24th months was lower in comparison to preoperative data and was considered to be statistically significant ( p < .05). The constant score, an average of all postoperative measurements and scores, was found to be higher than preoperative values and was considered to be statistically significant ( p < .01). There was a significant difference in the operated and non-operated forearm supination and elbow flexion muscle strength measurements at the postoperative 3- and 6-month follow-ups ( p < .01). Conclusion Arthroscopic biceps tenodesis into the anchors of the lateral row in combination with rotator cuff repair provides an increase in the strength of elbow flexion and forearm supination, while decreasing pain. Level of Evidence Level IV
Family firm heterogeneity on CSR approach: A socio-emotional (SEW) perspective
Authors: Diéguez-Soto Julio , Campos-Valenzuela Marta , Callejón-Gil Ángela M. , Aldeanueva-Fernández Ignacio 
Published: December 2021

How family firms adopt a certain corporate social responsibility (CSR) approach remains a relatively unexplored matter in family firm and firm ethics research. Hence, we study how and why the CSR approach (broad vs. narrow; benefits vs. costs) differs within family firms, addressing the influence of the socio-emotional wealth (SEW) dimensions, individually or combined. We used empirical evidence gathered through 13 case studies of firms from the Andalusia region and we used the interpretative approach of the grounded theory based on case study data. Results of our analyses lead to propose that family firms with a higher identification and more positive than negative valence with regard to emotional attachment and family enrichment dimensions will be more likely to exhibit a broad approach of CSR. Likewise, those family firms adopting CSR actions with stakeholders due to instrumental use of image and reputation dimension will more probably display a benefits approach. JEL CLASSIFICATION: L26; M14
Italian Version of the YQOL‐DHH Questionnaire: Translation and Cross‐cultural Adaptation
Authors: Gragnaniello Manuela , Celletti Claudia , Resca Alessandra , Galeoto Giovanni , Camerota Filippo 
Published: December 2021

ObjectiveTo translate and cross‐culturally adapt into Italian the YQOL‐DHH (Youth Quality of Life Instrument–Deaf and Hard of Hearing Module), an instrument to evaluate the health‐related quality of life in young deaf people. It could be useful for professionals, teachers, and parents to take care of deaf adolescents’ needs.Study DesignForward‐backward translation, cross‐cultural adaptation, and cognitive debriefing.SettingThe cognitive debriefing was performed online with professionals and during clinical practice with deaf adolescents.MethodsA methodological study was conducted according to the guidelines provided by the development team. The study consisted of a forward‐backward translation and a cross‐cultural adaptation. After the original authors’ confirmation, a cognitive debriefing was conducted with 30 professionals who work with deaf young people and with 10 deaf adolescents aged 11 to 18 years.ResultsFor the linguistic translation and cross‐cultural adaptation, some variations to the original instrument were made to obtain equivalence, such as the expression “deaf or hard of hearing” translated only with the Italian word “sordo.” During the cognitive debriefing, the clarity and comprehensibility of the items were reported by professionals and deaf adolescents. Eventually, the authors approved the final version.ConclusionThe YQOL‐DHH was translated and culturally adapted into Italian. The translated items were pertinent to the Italian culture and equivalent to the original ones. A validation study is suggested to make the instrument feasible for use in different clinical or educational contexts. In addition, to guarantee accessibility and autonomy for young deaf signers, Italian Sign Language translation of the questionnaire is suggested.
Symptom rates and profile clustering in tuberous sclerosis complex-associated neuropsychiatric disorders (TAND)
Authors: Alperin Samuel , Krueger Darcy A. , Franz David N. , Agricola Karen D. , Stires Gabrielle , Horn Paul S. , Capal Jamie K. 
Published: December 2021

Abstract
Background
Tuberous Sclerosis Complex (TSC) is associated with a range of neuropsychiatric difficulties, appropriately termed TSC-Associated Neuropsychiatric Disorders (TAND). The objectives of the study were to analyze the rates of TAND symptoms in a cohort of patients seen at the TSC Center of Excellence at Cincinnati Children’s Hospital and to identify clinically meaningful profiles based on TAND symptoms.

Methods
Data from the TAND Checklist was obtained from participants seen at the TSC Center of Excellence at Cincinnati Children’s Hospital Medical Center from June 2015 to August 2018. Cluster and factor analyses for each TAND symptom were performed. Factor scores were then calculated for participants, and a K-means cluster analysis of these scores was used to empirically identify distinct overall TAND symptom profiles occurring in TSC.

Results
A total of 1545 checklists was completed for 668 participants (37% adults and 63% children). Approximately 90% of participants reported at least one TAND symptom with an average of 12 symptoms (out of 29). Symptom rates ranged between 5 and 60%. The most common symptoms were neuropsychologic symptoms. A seven-cluster and seven-factor solution were found to be optimal. K-means cluster analysis resulted in a seven-profile solution, ranging from low to high symptom burden.

Conclusion
This study is the first to identify natural phenotypic profiles of TAND symptoms. Study of specific TAND subpopulations with shared profiles may facilitate better understanding of the underlying biology of TAND and better assessment of more targeted treatments.
Multiple trait breeding programs with genotype-by-environment interactions based on reaction norms, with application to genetic improvement of disease resilience
Authors: Dekkers Jack C. M. 
Published: December 2021

Abstract
Background
Genotype-by-environment interactions for a trait can be modeled using multiple-trait, i.e. character-state, models, that consider the phenotype as a different trait in each environment, or using reaction norm models based on a functional relationship, usually linear, between phenotype and a quantitative measure of the quality of the environment. The equivalence between character-state and reaction norm models has been demonstrated for a single trait. The objectives of this study were to extend the equivalence of the reaction norm and character-state models to a multiple-trait setting and to both genetic and environmental effects, and to illustrate the application of this equivalence to the design and optimization of breeding programs for disease resilience.

Methods
Equivalencies between reaction norm and character-state models for multiple-trait phenotypes were derived at the genetic and environmental levels, which demonstrates how multiple-trait reaction norm parameters can be derived from multiple-trait character state parameters. Methods were applied to optimize selection for a multiple-trait breeding goal in a target environment based on phenotypes collected in a healthy and disease-challenged environment, and to optimize the environment in which disease-challenge phenotypes should be collected.

Results and conclusions
The equivalence between multiple-trait reaction norm and multiple-trait character-state parameters allow genetic improvement for a multiple-trait breeding goal in a target environment to be optimized without recording phenotypes and estimating parameters for the target environment.
The effect of lipocalin-2 (LCN2) on apoptosis: a proteomics analysis study in an LCN2 deficient mouse model
Authors: Wu Dongming , Wang Xiaopeng , Han Ye , Wang Yayun 
Published: December 2021

Abstract
Background
Recent studies have shown that lipocalin-2 (LCN2) has multiple functions involved in various biological and pathological processes including energy homeostasis, cancer, inflammation, and apoptosis. We aimed to investigate the effect of LCN2 on apoptosis that influences the pathogenetic process of metabolic diseases and cancer.

Methods
We performed a proteomics analysis of livers taken from LCN2-knockout mice and wild type mice by using label-free LC-MS/MS quantitative proteomics.

Results
Proteomic analysis revealed that there were 132 significantly differentially expressed proteins (49 upregulated and 83 downregulated) among 2140 proteins in the liver of LCN2-knockout mice compared with wild type mice. Of these, seven apoptosis-associated proteins were significantly upregulated and seven apoptosis-associated proteins downregulated.

Conclusion
Proteomics demonstrated that there were seven upregulated and seven downregulated apoptosis-associated proteins in liver of LCN2-knockout mice. It is important to clarify the effect of LCN2 on apoptosis that might contribute to the pathogenesis of insulin resistance, cancer, and various nervous system diseases.
A PIP-mediated osmotic stress signaling cascade plays a positive role in the salt tolerance of sugarcane
Authors: Tang Hanchen , Yu Qing , Li Zhu , Liu Feng , Su Weihua , Zhang Chang , Ling Hui , Luo Jun , Su Yachun , Que Youxiong 
Published: December 2021

Abstract
Background
Plasma membrane intrinsic proteins (PIPs) are plant channel proteins involved in water deficit and salinity tolerance. PIPs play a major role in plant cell water balance and responses to salt stress. Although sugarcane is prone to high salt stress, there is no report on PIPs in sugarcane.

Results
In the present study, eight PIP family genes, termed ScPIP1–1, ScPIP1–2, ScPIP1–3, ScPIP1–4, ScPIP2–1, ScPIP2–2, ScPIP2–4 and ScPIP2–5, were obtained based on the sugarcane transcriptome database. Then, ScPIP2–1 in sugarcane was cloned and characterized. Confocal microscopy observation indicated that ScPIP2–1 was located in the plasma membrane and cytoplasm. A yeast two-hybridization experiment revealed that ScPIP2–1 does not have transcriptional activity. Real time quantitative PCR (RT-qPCR) analysis showed that ScPIP2–1 was mainly expressed in the leaf, root and bud, and its expression levels in both below- and aboveground tissues of ROC22 were up-regulated by abscisic acid (ABA), polyethylene glycol (PEG) 6000 and sodium chloride (NaCl) stresses. The chlorophyll content and ion leakage measurement suggested that ScPIP2–1 played a significant role in salt stress resistance in Nicotiana benthamiana through the transient expression test. Overexpression of ScPIP2–1 in Arabidopsis thaliana proved that this gene enhanced the salt tolerance of transgenic plants at the phenotypic (healthier state, more stable relative water content and longer root length), physiologic (more stable ion leakage, lower malondialdehyde content, higher proline content and superoxide dismutase activity) and molecular levels (higher expression levels of AtKIN2, AtP5CS1, AtP5CS2, AtDREB2, AtRD29A, AtNHX1, AtSOS1 and AtHKT1 genes and a lower expression level of the AtTRX5 gene).

Conclusions
This study revealed that the ScPIP2–1-mediated osmotic stress signaling cascade played a positive role in plant response to salt stress.
Clinical characteristics and outcome of primary brain abscess: a retrospective analysis
Authors: Huang Junying , Wu Haining , Huang Honghong , Wu Weiqi , Wu Bowen , Wang Lingxing 
Published: December 2021

Abstract
Background
Patients with primary brain abscess often present with atypical symptoms, and the outcome varies. We investigated the demographic, laboratory, and neuroimaging features of patients with brain abscess at our hospital and identified factors associated with their outcomes.

Methods
We retrospectively collected the data of patients diagnosed with primary brain abscess at our hospital between January 2011 and December 2020. Their clinical characteristics, predisposing factors, laboratory and neuroimaging findings, treatment, and outcome were analyzed.

Results
Of the 57 patients diagnosed with primary abscess, 51 (89.47%) were older than 40 years, and 42 (73.68%) were male. Only eight patients (14.04%) showed the classical triad of headache, fever, and focal neurological deficit. Fifteen patients (26.31%) had comorbidities, of which diabetes mellitus was the most common. Positive intracranial purulent material cultures were obtained in 46.15% of the patients, and gram-negative enteric bacteria were found in 33.33% of them, with Klebsiella pneumoniae being the most frequently observed. Surgical treatment, most commonly in the form of stereotactic drainage, was received by 54.39% of the patients. Good outcomes were achieved in 75.44% of the patients. Multivariate logistic regression analysis showed that patients with headaches were more likely to have a poor outcome (odds ratio 6.010, 95% confidence interval 1.114–32.407, p = 0.037).

Conclusions
Male patients and those older than 40 years were more susceptible to brain abscess than female patients and those younger than 40 years, respectively. Only a few patients showed the classical triad of clinical symptoms. Diabetes mellitus was the most common comorbidity. Positive intracranial specimens’ culture results were uncommon, with gram-negative enteric bacteria, especially Klebsiella pneumoniae, being the main organisms found. Most patients had a good outcome, and the presence of headache may influence the outcome.