bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between sound perception and acoustics of seat‐belt warning sound
Authors: Qi Tong , Yang Jinrong 
Published: September 2021

AbstractUnderstanding the comprehensive sound perceptions is a major challenge in translating the affective needs and responses of drivers and passengers into the human‐centered design of seat‐belt warning sound (SBWS). Due to the various sound impressions of SBWS, sound quality has multiple impacts on driving safety, pleasure, stress, and so forth. This paper aims to derive a specified psychological factor structure for the sound perceptions of SBWS and to rebuild the connections between the psychological and acoustic attributes. Kansei (emotional or affective) evaluation is employed to collect the affective responses to 20 sound stimuli from 10 experts and 134 other participants. The perceived sound quality is expressed by 11 psychological attributes: “cheerful,” “interesting,” “lovely,” “comfortable,” “nervous,” “cordial,” “advanced,” “crisp,” “nostalgic,” “aroused,” and “weak.” Russell's emotional state model is also employed to map the sounds into a Pleasure–Arousal Kansei space for further analysis. For acoustic attributes, we measure amplitude, frequency, pause ratio, repetition speed, and element number, which are easy to be tuned according to the design guidelines listed as follows: First, a decrease in sound frequency results in sleepiness perception (less perceived urgency); second, fewer element (peak) number per cycle results in displeasure perception (less satisfaction); third, lower repetition speed results in pleasure and sleepiness perceptions simultaneously. The multiple linear regression model further indicates the quantitative psychoacoustic relationships, which helps sound designers to identify the key acoustic attributes and predict the affective responses for the human‐centered design of SBWS.
Macrophage migration inhibitory factor gene polymorphisms (SNP ‐173 G>C and STR‐794 CATT5‐8) confer risk of plaque psoriasis: A case–control study
Authors: Hernández‐Bello Jorge , Rodríguez‐Puente Miroslaba , Gutiérrez‐Cuevas Jorge , García‐Arellano Samuel , Muñoz‐Valle José Francisco , Fafutis‐Morris Mary , Villanueva‐Quintero Delfina Guadalupe , Alvarado‐Navarro Anabell 
Published: September 2021

AbstractBackgroundMacrophage inhibitory factor (MIF) is a pro‐inflammatory cytokine secreted by several cells, including those in the immune system and the skin. TheMIFgene contains the SNP ‐173 G> C and STR ‐794 CATT5‐8polymorphisms in the promoter region capable of affecting its activity. Our objective was to investigate theMIFpolymorphisms as a risk factor for plaque psoriasis (PP) in the Mexican population.MethodsWe genotyped bothMIFpolymorphism (rs5844572 and rs755622) in 224 PP patients with a clinical and histopathological diagnosis and 232 control subjects (CS) by the PCR‐RFLP method. MIF serum levels were determined by an ELISA kit.ResultsWe found significant differences in the genotypic and allelic frequencies for theMIF‐173 G>C polymorphism; carriers of the GC genotype (OR 1.51, 95% CI 1.026–2.228,p = 0.03) and the C allele (OR 1.34, 95% CI 1.005–1.807,p = 0.04) had higher odds to present with PP. Moreover, the 6C haplotype was associated with PP risk (OR 2.10, 95% CI 1.22–3.69,p < 0.01). Also, the ‐173 CC genotype was associated with high MIF serum levels (p < 0.05).ConclusionsThe ‐173 GC genotype and the 6C haplotype of theMIFpolymorphisms are associated with susceptibility to PP in the Mexican population.
The unmet needs for identifying the ideal bowel preparation
Authors: Tontini Gian E , Prada Alberto , Sferrazza Sandro , Ciprandi Giorgio , Vecchi Maurizio 
Published: September 2021

AbstractColonoscopy, since it was first employed over 60 years ago, is now the gold standard method for visualizing the mucosa of the colon, but should be of good quality. Many factors affect quality, including the type of health service organization, type of facility, staff, equipment, patient characteristics, and bowel preparation (BP). The adequacy of bowel cleansing is critical, but, unfortunately, may be inadequate in up to one‐third of procedures. The current article will present and discuss the main BPs and their drawbacks, which include patient‐dependent and procedure‐dependent factors. Cleansing quality depends on the ease/complexity of solution preparation, volume, taste, and timing of consumption. Consequently, important positive factors include simple instructions, easy preparation of the solution, low volume, pleasant taste, short drinking time (e.g. <30 min), and splitting the dose between the evening before and the morning of the colonoscopy (or even better, only one dose in the early morning to avoid night‐time problems), and short onset of action. The BP solution must also be safe with negligible side effects. Furthermore, a positive experience supports patient willingness to repeat the procedure.
Angiography‐guided mid/high septal implantation of ventricular leads in patients with congenital heart disease
Authors: Shenthar Jayaprakash , Valappil Sanjai P. , Rai Maneesh K. , Banavalikar Bharatraj , Padmanabhan Deepak , Delhaas Tammo 
Published: September 2021

AbstractBackgroundConduction system pacing prevents pacing‐induced cardiomyopathy, but it can be challenging to perform in patients with congenital heart disease (CHD), and mid/high septal lead implantation is an alternative. This study aimed to assess intraprocedural angiography's utility as a guide for mid/high‐septal lead implantation in CHD patients.MethodsThe study subjects were CHD patients with Class I/IIa indications for permanent pacemaker implantation. To guide septal lead implantation, we performed an intraprocedural right ventricular angiogram in anteroposterior, 40° left anterior oblique, and 30° right anterior oblique. The primary endpoint was the lead tip in the mid/high septum on computed tomography (CT). The secondary endpoints were complications and systemic ventricular function on follow‐up.ResultsFrom January 2008 to December 2018, we enrolled 27 patients (mean age: 30 ± 20 years; M:F 17:10) with CHD (unoperated: 20, operated: 7). The mean paced QRS duration was 131.7 ± 5.8 ms, and CT done in 22/27 patients confirmed the lead tip in the mid‐septum in 16, high septum in 5, and apical septum in 1 patient. There were no procedural complications, and during a mean follow‐up of 58 ± 35.2 months, there was no significant change in the systemic ventricular ejection fraction (56.4 ± 8.3% vs 53.9 + 5.9%, P = .08). Two patients with Eisenmenger syndrome died because of refractory heart failure.ConclusionsIntraprocedural angiography is safe and useful to guide mid/high‐septal lead implantation in CHD patients. Mid/high septal lead position preserves systemic ventricular function in patients with CHD during medium‐term follow‐up.
Shear strain and inflammation‐induced fixed charge density loss in the knee joint cartilage following ACL injury and reconstruction: A computational study
Authors: Orozco Gustavo A. , Eskelinen Atte S. A. , Kosonen Joonas P. , Tanaka Matthew S. , Yang Mingrui , Link Thomas M. , Ma Benjamin , Li Xiaojuan , Grodzinsky Alan J. , Korhonen Rami K. , Tanska Petri 
Published: September 2021

AbstractExcessive tissue deformation near cartilage lesions and acute inflammation within the knee joint after anterior cruciate ligament (ACL) rupture and reconstruction surgery accelerate the loss of fixed charge density (FCD) and subsequent cartilage tissue degeneration. Here, we show how biomechanical and biochemical degradation pathways can predict FCD loss using a patient‐specific finite element model of an ACL reconstructed knee joint exhibiting a chondral lesion. Biomechanical degradation was based on the excessive maximum shear strains that may result in cell apoptosis, while biochemical degradation was driven by the diffusion of pro‐inflammatory cytokines. We found that the biomechanical model was able to predict substantial localized FCD loss near the lesion and on the medial areas of the lateral tibial cartilage. In turn, the biochemical model predicted FCD loss all around the lesion and at intact areas; the highest FCD loss was at the cartilage–synovial fluid‐interface and decreased toward the deeper zones. Interestingly, simulating a downturn of an acute inflammatory response by reducing the cytokine concentration exponentially over time in synovial fluid led to a partial recovery of FCD content in the cartilage. Our novel numerical approach suggests that in vivo FCD loss can be estimated in injured cartilage following ACL injury and reconstruction. Our novel modeling platform can benefit the prediction of PTOA progression and the development of treatment interventions such as disease‐modifying drug testing and rehabilitation strategies.
2‐Arachidonoyl glycerol potently induces cholecystokinin secretion in murine enteroendocrine STC‐1 cells via cannabinoid receptor CB1
Authors: Ochiai Keita , Hirooka Rina , Sakaino Masayoshi , Takeuchi Shigeo , Hira Tohru 
Published: September 2021

AbstractCholecystokinin (CCK) is a peptide hormone secreted from enteroendocrine cells and regulates the exocrine pancreas, gastric motility, and appetite. Dietary triacylglycerols are hydrolyzed to fatty acids (FA) and 2‐monoacylglycerols (2‐MAG) in the small intestine. Although it is well known that FA stimulate CCK secretion, whether 2‐MAG have the CCK‐releasing activity remains unclear. We examined the CCK‐releasing activity of four commercially available 2‐MAG in a murine CCK‐producing cell line, STC‐1, and the molecular mechanism underlying 2‐MAG‐induced CCK secretion. CCK released from the cells was measured using ELISA. Among four 2‐MAG (2‐palmitoyl, 2‐oleoyl, 2‐linoleoyl, and 2‐arachidonoyl monoacylglycerols) examined, 2‐arachidonoyl glycerol (2‐AG) potently stimulated CCK secretion in a dose‐dependent manner. Structurally related compounds, such as 2‐arachidonoyl glycerol ether and 1‐arachidonoyl glycerol, did not stimulate CCK secretion. Both arachidonic acid and 2‐AG stimulated CCK secretion at 100 μM, but only 2‐AG did at 50 μM. 2‐AG‐induced CCK secretion but not arachidonic acid‐induced CCK secretion was attenuated by treatment with a cannabinoid receptor 1 (CB1) antagonist. These results indicate that a specific 2‐MAG, 2‐AG, directly stimulates CCK secretion via CB1.
A review on potentials and challenges of nanolubricants as promising lubricants for electric vehicles
Authors: Ahmed Abdalglil Mustafa Waleed , Dassenoy Fabrice , Sarno Maria , Senatore Adolfo 
Published: September 2021

AbstractThe most remarkable difference between electric vehicles (EVs) and conventional ones is the fuel burning dependency of the internal combustion engine, while the emerging EVs operate on electric motors. These alternations create staggering shifts in both lubricants' market demand and performance specifications. Lubricants for electrical powertrain constitutes greases, transmission oils, and lubricants for auxiliary systems and do not rely on engine oils as internal combustion vehicles. The new standards will be more focused on lubricants' electrical properties such as breakage voltage and conductivity, coupled with tribological performance under high rpm, corrosion resistance and thermal management benchmarks. This paper thematically reviews the different studies performed with nanolubricants, and how they match EVs' operational requirements. Conclusions from this study can be considered as guidelines for the potential application of nanolubricants in EVs and possible future research that can be accomplished on the topic.
Photo‐Curing Vis‐IR Hybrid Fresnel Lenses with High Refractive Index
Authors: Qiu Yang , Li Jin , Li Tiantian , Ma Xiaodong , Jiang Xuesong 
Published: September 2021

AbstractConventional IR lenses, typically refractive lenses, composed of inorganic semiconductors or chalcogenide glasses, are usually bulky, heavy, and difficult processable. Here, a one‐step photo‐curing imprinting strategy is presented to fabricate lightweight, compact, and high refractive index (HRI) hybrid Fresnel lenses for optical devices based on thiol‐ene/‐yne reactions. The hybrid Fresnel lenses consist of two layers: the silicon/quartz as the support substrate and HRI polymer films as functional layer which are synthesized by thiol‐ene/‐yne reactions with high sulfur‐content comonomers 2,3‐bis((2‐mercaptoethyl)thio)‐1‐propanethiol (BMETP) and its derivatives. The as‐prepared photopolymer films exhibit excellent transparency properties and HRI above 1.62 both in the visible and infrared regions, resulting from the large ratio of sulfur element with high molar refraction. A series of images captured by vis‐IR hybrid Fresnel lenses are demonstrated to confirm the applicability in the area of the optical imaging technique. This strategy, based on the one‐step photo‐curing imprinting, integrating the advantages of the easy processability of organic polymers and high dimensional stability of the inorganic substrate materials, provides a facile, processable, and highly efficient process for fabricating lightweight optical lenses.
Electrospun Nanofibers: Materials, Synthesis Parameters, and Their Role in Sensing Applications
Authors: Kailasa Saraswathi , Reddy M. Sai Bhargava , Maurya Muni Raj , Rani B. Geeta , Rao K. Venkateswara , Sadasivuni Kishor Kumar 
Published: September 2021

AbstractSince the last decade, electrospinning is garnering more attention in the scientific research community, industries, applications like sensing (glucose, H2O2, dopamine, ascorbic acid, uric acid, neurotransmitter, etc.), biomedical applications (wound dressing, wound healing, skin, nerve, bone tissue engineering, and drug delivery systems), water treatment, energy harvesting, and storage applications. This review paper provides a brief overview of the electrospinning method, history of the electrospinning, factors affecting the electrospun nanofibers, and their morphology with different materials and composites (metals, metal oxides, 2D material, polymers and copolymers, carbon‐based materials, etc.) used in the electrospinning technique with optical spinning parameters. Moreover, this paper deliberates the application of electrospun nanofibers and fibrous mats for sensing (electrochemical, optical, fluorescence, colorimetric, mechanical, photoelectric, mass sensitive change, resistive, ultrasensitive, etc.) in most illustrative representations. In the end, the challenges, opportunities of the electrospun nanofibers, and new direction for future progress are also discussed.
High‐Performance Carbon Fibers Prepared by Continuous Stabilization and Carbonization of Electron Beam‐Irradiated Textile Grade Polyacrylonitrile Fibers
Authors: König Simon , Bauch Volker , Herbert Christian , Wego Andreas , Steinmann Mark , Frank Erik , Buchmeiser Michael R. 
Published: September 2021

AbstractThe manufacturing of high‐performance carbon fibers (CFs) from low‐cost textile grade poly(acrylonitrile) (PAN) homo‐ and copolymers using continuous electron beam (EB) irradiation, stabilization, and carbonization on a kilogram scale is reported. The resulting CFs have tensile strengths of up to 3.1 ± 0.6 GPa and Young's moduli of up to 212 ± 9 GPa, exceeding standard grade CFs such as Toray T300. Additionally, the Weibull strength and modulus, the microstructure, and the morphology of these CFs are determined.
Pharmacologic approaches to amino acid depletion for cancer therapy
Authors: Wilder Carly S. , Chen Zhao , DiGiovanni John 
Published: September 2021

AbstractCancer cells undergo metabolic reprogramming to support increased demands in bioenergetics and biosynthesis and to maintain reactive oxygen species at optimum levels. As metabolic alterations are broadly observed across many cancer types, metabolic reprogramming is considered a hallmark of cancer. A metabolic alteration commonly seen in cancer cells is an increased demand for certain amino acids. Amino acids are involved in a wide range of cellular functions, including proliferation, redox balance, bioenergetic and biosynthesis support, and homeostatic functions. Thus, targeting amino acid dependency in cancer is an attractive strategy for a number of cancers. In particular, pharmacologically mediated amino acid depletion has been evaluated as a cancer treatment option for several cancers. Amino acids that have been investigated for the feasibility of drug‐induced depletion in preclinical and clinical studies for cancer treatment include arginine, asparagine, cysteine, glutamine, lysine, and methionine. In this review, we will summarize the status of current research on pharmacologically mediated amino acid depletion as a strategy for cancer treatment and potential chemotherapeutic combinations that synergize with amino acid depletion to further inhibit tumor growth and progression.
Effectiveness of a Gamification Strategy to Prevent Childhood Obesity in Schools: A Cluster Controlled Trial
Authors: Peña Sebastián , Carranza Macarena , Cuadrado Cristóbal , Parra Diana C. , Villalobos Dintrans Pablo , Castillo Cecilia , Cortinez‐O’Ryan Andrea , Espinoza Paula , Müller Valeska , Rivera Cristián , Genovesi Romina , Riesco Juan , Kontto Jukka , Cerda Ricardo , Zitko Pedro 
Published: September 2021

ObjectiveThe aim of this study was to examine the effectiveness of a school‐based gamification strategy to prevent childhood obesity.MethodsSchools were randomized in Santiago, Chile, between March and May 2018 to control or to receive a nutrition and physical activity intervention using a gamification strategy (i.e., the use of points, levels, and rewards) to achieve healthy challenges. The intervention was delivered for 7 months and participants were assessed at 4 and 7 months. Primary outcomes were mean difference in BMI z score and waist circumference (WC) between trial arms at 7 months. Secondary outcomes were mean difference in BMI and systolic and diastolic blood pressure between trial arms at 7 months. ResultsA total of 24 schools (5 controls) and 2,197 students (653 controls) were analyzed. Mean BMI z score was lower in the intervention arm compared with control (adjusted mean difference −0.133, 95% CI: −0.25 to −0.01), whereas no evidence of reduction in WC was found. Mean BMI and systolic blood pressure were lower in the intervention arm compared with control. No evidence of reduction in diastolic blood pressure was found.ConclusionsThe multicomponent intervention was effective in preventing obesity but not in reducing WC. Gamification is a potentially powerful tool to increase the effectiveness of school‐based interventions to prevent obesity.
Enhanced thermal conductivity and mechanical properties of polymeric composites through formation of covalent bonds between boron nitride and rubber chains
Authors: Yang Dan , Wei Qungui , Yu Liyuan , Zhao Chengwang , Zhang Liqun 
Published: September 2021

AbstractHexagonal boron nitride (BN) platelets, also known as white graphite, are often used to improve the thermal conductivities of polymeric matrices. Due to the poor interfacial compatibility between BN platelets and polymeric matrices, in this study, polyrhodanine (PRd) was used to modify BN platelets and prepared functionalized BN‐PRd platelets, thereby enhancing the interfacial interaction between the thermal conductive filler and polymeric matrix. Then, BN‐PRd platelets were dispersed into the nitrile butadiene rubber (NBR) matrix to yield high thermally conductive composites. The presence of NC═S groups in PRd allowed the combination of PRd and NBR chains containing stable covalent bonds via vulcanization reaction. The thermal conductivity of the as‐prepared 30 vol% BN‐PRd/NBR composite reached 0.40 W/mK, representing an increment of 135% over pure NBR (0.17 W/mK). In addition, the largest tensile strength of NBR composite containing 30 vol% BN‐PRd platelets was 880% times of pure NBR. The 30 vol% BN‐PRd/NBR composite also displayed a relatively high dielectric constant (9.35 at 100 Hz) and a low dielectric loss tangent value (0.07 at 100 Hz), indicating their usefulness as dielectric flexible materials of microelectronics. In sum, the simplicity and good efficiency of formation of covalent bonds between boron nitride and rubber chains look very promising for large‐scale industrial production of high thermally conductive composites.
Association of coccygodynia with pelvic floor symptoms in women with pelvic pain
Authors: Neville Cynthia E. , Carrubba Aakriti R. , Li Zhuo , Ma Yaohua , Chen Anita H. 
Published: September 2021

AbstractBackgroundCoccygodynia is a painful condition of the tailbone that occurs more commonly in females. The association of coccyx pain with pelvic floor symptoms and the prevalence of coccyx pain in women with pelvic pain has not previously been reported.ObjectiveTo identify the prevalence of coccygodynia in women with pelvic pain and to describe the association of coccygodynia with pelvic floor examination findings and symptoms.DesignRetrospective cohort analysis.SettingTertiary medical institution.ParticipantsOne hundred twenty‐seven women presenting for outpatient pelvic floor physical therapy treatment who underwent vaginal and rectal pelvic floor examination.Main Outcome MeasuresPrevalence of coccygodynia, pain scores, association of coccygodynia with other comorbidities and diagnoses, and association of coccygodynia with physical examination findings.ResultsSixty‐three (49.6%) of 127 women with pelvic pain presented with coccygodynia and 64 (50.4%) did not. Women with coccygodynia had significantly higher rates of muscle spasm (50.8% vs. 31.2%, p = .025) higher visual analog scale pain scores (median 5 vs. 3, p = .014), higher rates of outlet dysfunction constipation (31.7% vs. 10.0%, p = .032), and higher rates of fibromyalgia (15.9% vs. 3.1%, p = .014). On pelvic examination, women with coccygodynia were significantly more likely to have sacrococcygeal joint hypomobility (65.1% vs. 14.1%, p < .001), coccygeus muscle spasm (77.8% vs. 17.2%, p < .001), anococcygeal ligament pain (63.5% vs. 9.4%, p < .001), external anal sphincter pain/spasm (33.3% vs. 13.1%, p < .001), and impaired pelvic floor muscle coordination (77.8% vs. 57.8%, p = .016).ConclusionsAlmost 50% of women seeking pelvic floor physical therapy for pelvic pain had coexisting coccygodynia. These women had higher pain scores, increased pelvic floor dysfunction, and significantly greater abnormal physical exam findings. This study demonstrates a strong link between coccygodynia, pelvic floor symptoms, and pelvic pain and highlights the importance of screening for and identifying coccyx pain when evaluating women with pelvic pain.