bluuebunny/crossref_metadata_2025_split huggingface dataset:
How efficacious are Octreotide and Somatostatin in the management of chylothorax in congenital cardiac surgical patients?
Authors: Madhavan Sudharsan , Nakao Masakazu 
Published: May 2021

Summary
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was how efficacious are Octreotide and Somatostatin in the management of chylothorax in congenital cardiac surgical patients. Altogether &gt;55 papers were found using the reported search, of which 8 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. The comparative data on LOS and chylothorax duration are mixed though interpretation is difficult since Octreotide has been instituted belatedly from the onset of chylothorax in multiple instances. There is also preliminary evidence to suggest that responders to Somatostatin and Octreotide are affected by single-ventricle physiology and CVP levels. Meanwhile, non-responders tend to have higher mortality and may merit earlier surgical intervention. The included studies thus far have significant limitations such as low-level evidence study design, selection bias, variability in duration and dosage of therapy and heterogenous comparative arms. Notwithstanding these limitations, Octreotide has shown to be an useful adjunct treatment in reducing chylothorax volume especially in patients with higher output chylothorax (&gt;40 ml/kg/h) after the failure of conservative management.
HIV drug resistance among adults initiating antiretroviral therapy in Uganda
Authors: Watera Christine , Ssemwanga Deogratius , Namayanja Grace , Asio Juliet , Lutalo Tom , Namale Alice , Sanyu Grace , Ssewanyana Isaac , Gonzalez-Salazar Jesus Fidel , Nazziwa Jamirah , Nanyonjo Maria , Raizes Elliot , Kabuga Usher , Mwangi Christina , Kirungi Wilford , Musinguzi Joshua , Mugagga Kaggwa , Mbidde Edward Katongole , Kaleebu Pontiano 
Published: May 2021

Abstract

Background
WHO revised their HIV drug resistance (HIVDR) monitoring strategy in 2014, enabling countries to generate nationally representative HIVDR prevalence estimates from surveys conducted using this methodology. In 2016, we adopted this strategy in Uganda and conducted an HIVDR survey among adults initiating or reinitiating ART.

Methods
A cross-sectional survey of adults aged ≥18 years initiating or reinitiating ART was conducted at 23 sites using a two-stage cluster design sampling method. Participants provided written informed consent prior to enrolment. Whole blood collected in EDTA vacutainer tubes was used for preparation of dried blood spot (DBS) specimens or plasma. Samples were shipped from the sites to the Central Public Health Laboratory (CPHL) for temporary storage before transfer to the Uganda Virus Research Institute (UVRI) for genotyping. Prevalence of HIVDR among adults initiating or reinitiating ART was determined.

Results
Specimens from 491 participants (median age 32 years and 61.5% female) were collected between August and December 2016. Specimens from 351 participants were successfully genotyped. Forty-nine had drug resistance mutations, yielding an overall weighted HIVDR prevalence of 18.2% with the highest noted for NNRTIs at 14.1%.

Conclusions
We observed a high HIVDR prevalence for NNRTIs among adults prior to initiating or reinitiating ART in Uganda. This is above WHO’s recommended threshold of 10% when countries should consider changing from NNRTI- to dolutegravir-based first-line regimens. This recommendation was adopted in the revised Ugandan ART guidelines. Dolutegravir-containing ART regimens are preferred for first- and second-line ART regimens.
Comparative analysis of competency coverage within accredited master’s in health informatics programs in the East African region
Authors: Were Martin C , Gong Wu , Balirwa Priscillah , Balugaba Bonny Enock , Yeung Ada , Pierce Leslie , Ingles Donna , Kim Young , Lee Hyeon Jeong , Shepherd Bryan E 
Published: May 2021

Abstract

Objective
As master of science in health informatics (MSc HI) programs emerge in developing countries, quality assurance of these programs is essential. This article describes a comprehensive comparative analysis of competencies covered by accredited MSc HI programs in the East African common labor and educational zone.

Materials and Methods
Two reviewers independently reviewed curricula from 7 of 8 accredited MSc HI university programs. The reviewers extracted covered competencies, coding these based on a template that contained 73 competencies derived from competencies recommended by the International Medical Informatics Association, plus additional unique competencies contained within the MSc HI programs. Descriptive statistics were used to summarize the structure and completion requirements of each MSc HI program. Jaccard similarity coefficient was used to compare similarities in competency coverage between universities.

Results
The total number of courses within the MSc HI degree programs ranged from 8 to 22, with 35 to 180 credit hours. Cohen’s kappa for coding competencies was 0.738. The difference in competency coverage was statistically significant across the 7 institutions (P = .012), with covered competencies across institutions ranging from 32 (43.8%) to 49 (67.1%) of 73. Only 4 (19%) of 21 university pairs met a cutoff of over 70% similarity in shared competencies.

Discussion
Significant variations observed in competency coverage within MSc HI degree programs could limit mobility of student, faculty, and labor.

Conclusions
Comparative analysis of MSc HI degree programs across 7 universities in East Africa revealed significant differences in the competencies that were covered.
Design thinking in applied informatics: what can we learn from Project HealthDesign?
Authors: Novak Laurie L , Harris Joyce W , Koonce Taneya Y , Johnson Kevin B 
Published: May 2021

Abstract

Objective
The goals of this study are to describe the value and impact of Project HealthDesign (PHD), a program of the Robert Wood Johnson Foundation that applied design thinking to personal health records, and to explore the applicability of the PHD model to another challenging translational informatics problem: the integration of AI into the healthcare system.

Materials and Methods
We assessed PHD’s impact and value in 2 ways. First, we analyzed publication impact by calculating a PHD h-index and characterizing the professional domains of citing journals. Next, we surveyed and interviewed PHD grantees, expert consultants, and codirectors to assess the program’s components and the potential future application of design thinking to artificial intelligence (AI) integration into healthcare.

Results
There was a total of 1171 unique citations to PHD-funded work (collective h-index of 25). Studies citing PHD span medical, legal, and computational journals. Participants stated that this project transformed their thinking, altered their career trajectory, and resulted in technology transfer into the commercial sector. Participants felt, in general, that the approach would be valuable in solving contemporary challenges integrating AI in healthcare including complex social questions, integrating knowledge from multiple domains, implementation, and governance.

Conclusion
Design thinking is a systematic approach to problem-solving characterized by cooperation and collaboration. PHD generated significant impacts as measured by citations, reach, and overall effect on participants. PHD’s design thinking methods are potentially useful to other work on cyber–physical systems, such as the use of AI in healthcare, to propose structural or policy-related changes that may affect adoption, value, and improvement of the care delivery system.
Effect of ractopamine hydrochloride on environmental gas emissions, growth performance, and carcass characteristics in feedlot steers
Authors: Ross Elizabeth G , Ball Jase J , Werth Samantha J , Mejia-Turcios Sebastian E , Zhao Yongjing , Pan Yuee , Taube Patrick C , Meinert Todd R , Van Engen Nicholas K , Mitloehner F M 
Published: May 2021

Abstract
With a growing global population and increased environmental concerns around animal agriculture, it is essential to humanely maximize animal performance and reduce environmental emissions. This study aims to determine the efficacy of feeding ractopamine hydrochloride (RAC), an orally active, β 1-adrenergic agonist (β1AA), to feedlot steers in the last 42 d of finishing to reduce ammonia (NH3) emissions and improve animal performance. A randomized complete block design was used to allocate 112 Angus and crossbred Angus steers (initial body weight [BW] = 566.0 ± 10.4 kg) to 8 cattle pen enclosures. Pens (n = 4 per treatment, 14 steers per pen, and 56 steers per treatment) were randomly assigned to one of two treatments: 1) CON; finishing ration containing no RAC, 2) RAC; finishing ration containing 27.3 g/907 kg dry matter (DM) basis RAC. Steers were weighed on day −1 and 0 before treatment and day 14, 28, and 42 during treatment. Treatment rations were mixed and delivered daily by masked personnel. Measured emissions included NH3, nitrous oxide (N2O), methane (CH4), hydrogen sulfide (H2S), and carbon dioxide (CO2). The primary response variables assessed were emissions standardized by live weight (LW) and hot carcass weight (HCW). Steers were harvested on day 43 and carcass data were collected on day 43 and 44. Steers fed RAC reduced NH3 emissions by 17.21% from day 0 to 28 (P = 0.032) and tended to reduce NH3 from day 0 to 42 by 11.07% (P = 0.070) vs. CON. When standardized for LW, NH3 was reduced by 23.88% from day 0 to 14 (P = 0.018), 17.80% from day 0 to 28 (P = 0.006), and 12.50% for day 0 to 42 (P = 0.027) in steers fed RAC vs. CON. Steers fed RAC had 14.05% (P = 0.013) lower cumulative NH3 emissions when standardized by HCW vs. CON. Feeding RAC to Steers reduced H2S by 29.49% from day 0 to 14 (P = 0.009) and tended to reduce H2S over day 0 to 28 by 11.14% (P = 0.086) vs. CON. When H2S emissions were standardized for LW, RAC fed steers had a 28.81% reduction from day 0 to 14 (P = 0.008) vs. CON. From day 0 to 42 the RAC fed steers tended to have a 0.24 kg/d greater average daily gain (ADG) (P = 0.066) and tended to eat 4.27% less (P = 0.069) on a DM basis vs. CON. The RAC fed steers had a 19.95% greater gain to feed ratio (G:F) compared to CON (P = 0.012). Steers fed RAC had an average of 12.52 kg greater HCW (P = 0.006) and an increase of 1.93 percentage units in dressing percent (DP) (P = 0.004) vs. CON. Ractopamine is an effective medicated feed additive for reducing NH3 and improving end product performance through HCW yields.
Vascular tracheobronchial compression syndrome secondary to contained ruptured thoracic aortic aneurysm
Authors: Dinh Krystal , Manuel Lucy , Somers Miles , Vicaretti Mauro 
Published: May 2021

Abstract
Vascular tracheobronchial compression syndrome is the compression of the trachea or pulmonary bronchus by a vascular structure. It is primarily a diagnosis in children and secondary to congenital vascular anomalies. In adults, vascular tracheobronchial compression syndrome can be either congenital or required with a vast majority of congenital conditions found incidentally on imaging. Acquired conditions are largely due to aortic arch aneurysms or kinking of the aorta. The case described herein illustrates the rare case of a saccular thoracic aneurysm causing compression of the left primary bronchus. Patients may have a history of gradual onset of symptoms involving both the airway and oesophagus. Vascular tracheobronchial compression syndrome may go undetected and asymptomatic throughout an individual’s lifespan, however as described herein this syndrome may also be life-threatening.
White Matter Alteration Following SWAT Explosive Breaching Training and the Moderating Effect of a Neck Collar Device: A DTI and NODDI Study
Authors: Yuan Weihong , Dudley Jonathan , Slutsky-Ganesh Alexis B , Leach James , Scheifele Pete , Altaye Mekibib , Barber Foss Kim D , Diekfuss Jed D , Rhea Christopher K , Myer Gregory D 
Published: May 2021

ABSTRACT

Introduction
Special Weapons and Tactics (SWAT) personnel who practice breaching with blast exposure are at risk for blast-related head trauma. We aimed to investigate the impact of low-level blast exposure on underlying white matter (WM) microstructure based on diffusion tensor imaging (DTI) and neurite orientation and density imaging (NODDI) in SWAT personnel before and after breacher training. Diffusion tensor imaging is an advanced MRI technique sensitive to underlying WM alterations. NODDI is a novel MRI technique emerged recently that acquires diffusion weighted data from multiple shells modeling for different compartments in the microstructural environment in the brain. We also aimed to evaluate the effect of a jugular vein compression collar device in mitigating the alteration of the diffusion properties in the WM as well as its role as a moderator on the association between the diffusion property changes and the blast exposure.

Materials and Methods
Twenty-one SWAT personnel (10 non-collar and 11 collar) completed the breacher training and underwent MRI at both baseline and after blast exposure. Diffusion weighted data were acquired with two shells (b = 1,000, 2,000 s/mm2) on 3T Phillips scanners. Diffusion tensor imaging metrices, including fractional anisotropy, mean, axial, and radial diffusivity, and NODDI metrics, including neurite density index (NDI), isotropic volume fraction (fiso), and orientation dispersion index, were calculated. Tract-based spatial statistics was used in the voxel-wise statistical analysis. Post hoc analyses were performed for the quantification of the pre- to post-blast exposure diffusion percentage change in the WM regions with significant group difference and for the assessment of the interaction of the relationship between blast exposure and diffusion alteration.

Results
The non-collar group exhibited significant pre- to post-blast increase in NDI (corrected P &lt; .05) in the WM involving the right internal capsule, the right posterior corona radiation, the right posterior thalamic radiation, and the right sagittal stratum. A subset of these regions showed significantly greater alteration in NDI and fiso in the non-collar group when compared with those in the collar group (corrected P &lt; .05). In addition, collar wearing exhibited a significant moderating effect for the alteration of fiso for its association with average peak pulse pressure.

Conclusions
Our data provided initial evidence of the impact of blast exposure on WM diffusion alteration based on both DTI and NODDI. The mitigating effect of WM diffusivity changes and the moderating effect of collar wearing suggest that the device may serve as a promising solution to protect WM against blast exposure.
Detection of metallicity correlations in 100 nearby galaxies
Authors: Li Zefeng , Krumholz Mark R , Wisnioski Emily , Mendel J Trevor , Kewley Lisa J , Sánchez Sebastian F , Galbany Lluís 
Published: May 2021

ABSTRACT
In this paper, we analyse the statistics of the 2D gas-phase oxygen abundance distributions of 100 nearby galaxies drawn from the Calar Alto Legacy Integral Field spectroscopy Area survey. After removing the large-scale radial metallicity gradient, we compute the two-point correlation functions of the resulting metallicity fluctuation maps. We detect correlations in the majority of our targets, which we show are significantly in excess of what is expected due to beam-smearing, and are robust against the choice of metallicity diagnostic. We show that the correlation functions are generally well-fit by the predictions of a simple model for stochastic metal injection coupled with diffusion, and from the model we show that, after accounting for the effects of both beam smearing and noise, the galaxies in our sample have characteristic correlation lengths of ∼1 kpc. Correlation lengths increase with both stellar mass and star formation rate, but show no significant variation with Hubble type, barredness, or merging state. We also find no evidence for a theoretically predicted relationship between gas velocity dispersion and correlation length, though this may be due to the small dynamic range in gas velocity dispersion across our sample. Our results suggest that measurements of 2D metallicity correlation functions can be a powerful tool for studying galaxy evolution.
GEPIA2021: integrating multiple deconvolution-based analysis into GEPIA
Authors: Li Chenwei , Tang Zefang , Zhang Wenjie , Ye Zhaochen , Liu Fenglin 
Published: May 2021

Abstract
In 2017, we released GEPIA (Gene Expression Profiling Interactive Analysis) webserver to facilitate the widely used analyses based on the bulk gene expression datasets in the TCGA and the GTEx projects, providing the biologists and clinicians with a handy tool to perform comprehensive and complex data mining tasks. Recently, the deconvolution tools have led to revolutionary trends to resolve bulk RNA datasets at cell type-level resolution, interrogating the characteristics of different cell types in cancer and controlled cohorts became an important strategy to investigate the biological questions. Thus, we present GEPIA2021, a standalone extension of GEPIA, allowing users to perform multiple interactive analysis based on the deconvolution results, including cell type-level proportion comparison, correlation analysis, differential expression, and survival analysis. With GEPIA2021, experimental biologists could easily explore the large TCGA and GTEx datasets and validate their hypotheses in an enhanced resolution. GEPIA2021 is publicly accessible at http://gepia2021.cancer-pku.cn/.
The Austerity of Lone Motherhood: Discrimination Law and Benefit Reform
Authors: Campbell Meghan 
Published: May 2021

Abstract
The austerity-motivated reforms of the UK benefit system have had a devastating and disproportionate impact on vulnerable groups. Lone mothers are challenging these regulations as discriminatory. Their claims raise an under-theorised question: how should courts adjudicate claims for status equality in the realm of fiscal policy? The courts are adopting a fragmented model of equality that artificially divides status and economic inequalities. This approach fails to fully account for the multiple dimensions of disadvantage at stake in these claims. Using a substantive equality framework, this article uncovers the intertwined status and economic inequalities perpetuated by the benefit reforms. It then proceeds to evaluate how the courts’ fragmented approach to equality distorts the justification evaluation. Substantive equality can enrich the justification analysis in a manner that both respects the institutional limits of the court and holds the government to account for discrimination in social benefits.
Zooplankton size spectra and production assessed by two different nets in the subarctic Northeast Pacific
Authors: Kwong Lian E , Pakhomov Evgeny A 
Published: May 2021

Abstract
Normalized biomass size spectra (NBSS) are frequently used to describe pelagic communities. However, the underlying structure of NBSS may lead to varying intercepts and slopes when only a portion of the biomass range is sampled. This may be further perpetuated by the sampling efficiency of different gears/mesh sizes. Spatial and seasonal effects of mesh size on zooplankton NBSS and production were evaluated. Zooplankton were collected during winter, spring and summer (2017–2019) between Vancouver Island and Station Papa (50°N, 145°W) using a 64-μm Working Party 2 (WP-2) net and a 236-μm bongo net and analyzed using a bench-top laser optic particle counter. WP-2 and bongo NBSS overlapped in 11 size classes, for which the WP-2 more effectively sampled smaller size classes and converged with the bongo in larger size classes. Differences in NBSS slopes from the two nets were detected, yet no differences in total production. However, the contribution of individual size classes to total production varied spatially and seasonally. Total production in the coastal region exhibited strong seasonal variability. Notably, summer estimates of production in the coastal region were at least 2-fold higher than transitional and open ocean regions. This study suggests that using one mesh size may underestimate zooplankton NBSS and thus production.
Democracy, Complexity, and Science: Exploring Structural Sources of National Scientific Performance
Authors: Whetsell Travis A , Dimand Ana-Maria , Jonkers Koen , Baas Jeroen , Wagner Caroline S 
Published: May 2021

AbstractScholars have long hypothesized that democratic forms of government are more compatible with scientific advancement. However, empirical analysis testing the democracy–science compatibility hypothesis remains underdeveloped. This article explores the effect of democratic governance on scientific performance using panel data on 124 countries between 2007–2017. We find evidence supporting the democracy–science hypothesis. Further, using both internal and external measures of complexity, we estimate the effects of complexity as a moderating factor between the democracy–science connection. The results show differential main effects of economic complexity, globalization, and international collaboration on scientific performance, as well as significant interaction effects that moderate the effect of democracy on scientific performance. The findings show the significance of democratic governance and complex systems in national scientific performance.
019 A Simple, Objective Estimate of Dietary Timing as a Circadian Biomarker
Authors: Hanlon Erin , Nesheiwat Wajdey , Sintetas Stephanie , Van Cauter Eve , Knutson Kristen 
Published: May 2021

Abstract

Introduction
The importance of diet for health has been recognized for centuries, yet, the focus has mostly been on what someone eats. Recently, however, focus has expanded to include when someone eats. Experimental studies that manipulated timing of food intake demonstrated effects on metabolic function. Most population-based studies have had to rely on self-reported methods to assess dietary behavior, including food logs or dietary recall, but self-report is subjective, error-prone, and burdensome. The goal of this analysis was to identify an objective estimate of dietary timing in clock time format. Further, we planned to examine whether sleep “chronotype” and this dietary “chronotype” are correlated.

Methods
We used continuous glucose monitoring (CGM), which involves inserting a small sensor into the back of a participant’s upper arm. It measures interstitial glucose levels every 5 minutes continuously for up to 2 weeks. We had 13 participants wear a CGM device for 2–10 days. We characterized dietary timing by simply identifying the clock time at which glucose levels were the highest. We identified this time point for each day and then calculated the mean clock time for each participant. Participants also wore wrist actigraphy for approximately one week and we calculated mean sleep start, sleep end, and midpoint times. We calculated intervals between highest glucose and sleep timing measures.

Results
The mean time of highest glucose was 16:57 (SD 3:05) and ranged from 11:16 to 22:27. The mean (SD) intervals were 10.4 (2.9) hours for sleep end to highest glucose, 13.5 (2.8) hours for midpoint to highest glucose, and 5.8 (2.8) hours for highest glucose to sleep start. The correlations between highest glucose and sleep timing were .13 (p=.70) for sleep start, .05 (p=.88) for sleep end, and -.19 (p=.55) for midpoint.

Conclusion
There was a wide range in the timing of highest glucose values in this sample, Further, the timing of highest glucose does not correlate with sleep timing, which indicates that these two timing measures are not redundant with one another. The timing of highest glucose from CGM may provide an objective, simple circadian biomarker of dietary behavior.

Support (if any)
P01A1011412-18A1