bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Menstrual Disorders in Two Different Areas, Hamedan and Zahedan in Iran, after the Injection of the COVID-19 Vaccine
Authors: Parvareshi Hamrah Razieh , Mehri Fereshteh , Najafi Vosough Roya , Rahbari Amir Hosein , Hoseinbar Saeed 
Published: February 2025

Background and Purpose:
After the injection of the COVID-19 vaccinations, many
women around the world have reported abnormalities in their menstrual periods. Hence, the objective
of our study was to compare the prevalence of menstrual abnormalities after the COVID-19
vaccine among females residing within two regions (Hamedan and Zahedan) that are different in
the length of sunlight in Iran.

Method:
The research (cross-sectional study) utilized a questionnaire to evaluate the menstrual status
following COVID-19 vaccination. Based on the determined sample size, 170 women were selected,
with 85 from Hamadan and 85 from Zahedan (both situated in Iran). Checklists were distributed
among women above the age of menarche in both regions who had been vaccinated, were not
pregnant or lactating, and did not have a history of primary ovarian insufficiency, hypothalamic
menopause, or hysterectomy. The demographic and clinical characteristics were assessed through
the questionnaire, which consisted of three parts: demographics, menstrual disorders after vaccination,
and length/repetition/quantity of menstruation disorders. Data analyzed using SPSS software at
descriptive and inferential levels included frequency, percentage, Chi-Square, and Fisher exact
tests, which were used for comparison.

Results:
A total of 170 females were included in our study; 85 females were from the Hamedan region,
and 85 females were from the Zahedan region. About 57.6% of participants reported menstrual
symptoms post-vaccination in the Hamedan region, and around 54.1% of women experienced
these disorders in the Zahedan region (P-value 0.643). The frequency of people in the study who
had disorders in length was higher in the Hamedan region (P-value 0.208). Also, disorders in the
intensity and recurrence of their menstruation were higher in the Hamedan region than in the
Zahedan region (P-value 0.054).

Conclusion:
This research has demonstrated a potential correlation between the intensity of menstrual
disorders experienced by women following the administration of the COVID-19 vaccine and
the duration of sun exposure, which impacts the level of vitamin D in the body. Hence, it is crucial
to comprehend and substantiate this association as it holds significant value for the well-being of
women and, subsequently, the health of future generations.
An Extensive Evaluation of Recent Developments in B. Orellana's Phytochemistry and Pharmacology
Authors: Akhtar Wasim , Sharma Himanchal , Ekbbal Rustam , Sharma Anuj Kumar 
Published: February 2025

Abstract:
Bixa Orellana, known as annatto, has gained significant attention due to its diverse
phytochemical composition and wide range of pharmacological activities. This review provides a
comprehensive evaluation of the latest advancements in the phytochemistry and pharmacology of
B. Orellana. The plant is rich in a variety of bioactive compounds, including carotenoids, flavonoids,
and tocotrienols, which contribute to its therapeutic potential. Recent studies have highlighted
the antioxidative, antimicrobial, anti-inflammatory, and anticancer properties of these
compounds, supporting the traditional use of B. Orellana in various ethno-medicinal practices.
Furthermore, the underlying mechanisms of action of these bioactive constituents are discussed,
with an emphasis on their interaction with molecular targets that regulate oxidative stress, inflammation,
and cell proliferation. The pharmacokinetics, safety profile, and potential side effects
of B. Orellana extracts are also reviewed, underscoring the need for further research to establish
standardized dosages and formulations. Additionally, the application of advanced extraction techniques
and novel delivery systems to enhance the bioavailability and efficacy of B. Orellanaderived
compounds is explored. This review aims to consolidate the current knowledge on B.
Orellana, providing insights into its potential as a source of natural therapeutics and laying the
groundwork for future research and development in this field. By synthesizing the findings from
recent studies, this paper contributes to a deeper understanding of B. Orellana’s pharmacological
potential, ultimately supporting its integration into modern healthcare practices.
A Review on Nanotechnology based In Situ Gelling System as a Reliable Weapon for Targeting Alzheimer’s Disease via Intranasal Route
Authors: Deorankar Priyanka , Minglani Vahid Vikram , Prajapati Bhupendra G. , Patel Meenakshi B. 
Published: February 2025

Abstract:
A recent World Health Organization report claims that along with the growing world
population and emerging life prospects, the prevalence of neurological disorders is also increasing.
Out of all neurological disorders, Alzheimer's disease is the most widespread and alarming concern.
The disease poses significant therapeutic challenges due to the blood-brain barrier's restrictiveness
and the lack of effective drug delivery systems. The olfactory and trigeminal nerves have direct access
to the brain, therefore, intranasal drug delivery can be a promising route for the direct delivery
of anti-Alzheimer’s drugs. Despite this advantage, brain targeting is limited through this route due
to mucociliary clearance. Thus, in situ, nanotechnology offers a transformative approach by leveraging
the intranasal route to directly target the central nervous system. This comprehensive review
discusses recent advancements, mechanisms, and applications of in situ nanotechnology in Alzheimer's
disease therapeutics, highlighting its potential to enhance drug delivery efficiency, improve
bioavailability, and mitigate the progression of this debilitating condition. The importance of intranasal
drug delivery has been emphasized in this review, along with the clear benefits of in situ lipid-
based nanotechnology for the efficient delivery of medication in targeting Alzheimer's disease.
An Approach to Analyze Chest X-ray Using Convolutional Neural Network for Effective Diagnosis of COVID-19
Authors: Dubey Anil Kumar , Kapoor Raman , Yadav Vikash 
Published: February 2025

Introduction:
The novel coronavirus has significantly affected the lives of people. The
exponentially increasing number of COVID-19 patients has put immense pressure on healthcare
services across the globe. Before the pandemic phase, the number of medical professionals per individual
was poor across many countries. Subsequently, the pressure on the medical fraternity has been
very high.

Method:
In such a situation, a fast and reliable diagnosis is expected to greatly help medical professionals.
With this view, we present an analysis of X-ray images, which will allow quarantine of highrisk
patients before final reports are available. This is expected to restrain the transmission of the
pandemic to a great extent. X-ray diagnostic facilities are relatively cheaper and readily available
compared with the reverse transcription-polymerase chain reaction (RT-PCR) tests.

Result:
Hence initial diagnosis using X-ray results is expected to be highly effective in segregating
patients of COVID-19. A deep learning (DL) based convolutional neural network (CNN) model is
presented, which detects high-risk patients of COVID-19 with an accuracy as high as 97.5.

Conclusion:
This method is expected to significantly reduce the load on medical professionals as
high-risk individuals can be quarantined before they cause any transmission.
Green Synthesis of Chlorophyllin-Based Ag Nanoparticles to Target Escherichia coli and Staphylococcus aureus
Authors: Podder Sandipa , Saha Saikat , Chakrovorty Arnob , Bhattacharjee Banani , Hossen Molla Sabir , Tarafdar Debojyoti , Nandi Sisir , Samadder Asmita 
Published: February 2025

Background:
Bacteria resist drugs by employing new resistance mechanisms, leading to
prolonged infection and complexity in therapeutic prognosis that concordantly decreases drug efficacy.
In recent years, nanotechnology has gained immense popularity for the development of drug
delivery systems to combat the global pharmaceutical crisis of multi-drug resistance.

Objective:
The present work aimed to focus on the green chemistry-based synthesis of silver nanoparticles
(AgNPs) using the phytocompound chlorophyllin to form chlorophyllin precipitated silver
nanoparticles (NCHL) and elucidate their application against two pathologically significant bacterial
species Escherichia coli and Staphylococcus aureus.

Methods:
After optimization of experimental parameters, the physico-chemical properties of the
synthesized NCHL were determined using AFM, DLS, XRD, UV-Vis, SPR, and FTIR, respectively.
The interaction of NCHL with ct-DNA was assessed using CD spectroscopy. The antimicrobial
activity of the synthesized NCHL against Escherichia coli and Staphylococcus aureus was examined
by a disc diffusion susceptibility test.

Results:
The NCHL was ascertained to be ~53.57 nm in size, having a spherical shape, smooth topology,
negative zeta potential of -23.94 mV, and PDI value of 0.495. A sharp peak for silver as
SPR and an XRD peak depicted the best fit metallic crystal synchronization. FTIR analysis revealed
the presence of a similar functional group in NCHL and chlorophyllin (CHL). CD spectroscopy
with ct-DNA in the presence of NCHL showed a change in spectral shift of the ct-DNA, indicating
strong ct-DNA-NCHL interaction. NCHL successfully inhibited the growth of both bacterial
strains, indicating broad spectrum activity of the synthesized nanoparticles.

Conclusion:
The promising results indicated that NCHL could be utilized as a potential therapeutic
molecule against Escherichia coli and Staphylococcus aureus infections and help in combating bacterial
drug resistance, which is of high medical priority.
Identifying Research Priorities in Digital Education for Health Care: Umbrella Review and Modified Delphi Method Study
Authors: Potter Alison , Munsch Chris , Watson Elaine , Hopkins Emily , Kitromili Sofia , O'Neill Iain Cameron , Larbie Judy , Niittymaki Essi , Ramsay Catriona , Burke Joshua , Ralph Neil 
Published: February 2025

Background
In recent years, the use of digital technology in the education of health care professionals has surged, partly driven by the COVID-19 pandemic. However, there is still a need for focused research to establish evidence of its effectiveness.

Objective
This study aimed to define the gaps in the evidence for the efficacy of digital education and to identify priority areas where future research has the potential to contribute to our understanding and use of digital education.

Methods
We used a 2-stage approach to identify research priorities. First, an umbrella review of the recent literature (published between 2020 and 2023) was performed to identify and build on existing work. Second, expert consensus on the priority research questions was obtained using a modified Delphi method.

Results
A total of 8857 potentially relevant papers were identified. Using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology, we included 217 papers for full review. All papers were either systematic reviews or meta-analyses. A total of 151 research recommendations were extracted from the 217 papers. These were analyzed, recategorized, and consolidated to create a final list of 63 questions. From these, a modified Delphi process with 42 experts was used to produce the top-five rated research priorities: (1) How do we measure the learning transfer from digital education into the clinical setting? (2) How can we optimize the use of artificial intelligence, machine learning, and deep learning to facilitate education and training? (3) What are the methodological requirements for high-quality rigorous studies assessing the outcomes of digital health education? (4) How does the design of digital education interventions (eg, format and modality) in health professionals’ education and training curriculum affect learning outcomes? and (5) How should learning outcomes in the field of health professions’ digital education be defined and standardized?

Conclusions
This review provides a prioritized list of research gaps in digital education in health care, which will be of use to researchers, educators, education providers, and funding agencies. Additional proposals are discussed regarding the next steps needed to advance this agenda, aiming to promote meaningful and practical research on the use of digital technologies and drive excellence in health care education.
Efektifitas Penegakan Hukum Oleh Satuan Polisi Pamong Praja Dan Wilayatul Hisbah Terhadap Penanganan Kasus Pelecehan Seksual Yang Diungkapkan Melalui Media Massa Di Kota Banda Aceh
Authors: Ti Safur  , Mahdalena  
Published: February 2025

Kajian ini untuk menjawab permasalahan Efektifitas Penegakan Hukum Oleh Satpol PP & WH dalam menangani kasus pelecehan seksual yang viral melalui media massa di Kota Banda Aceh, Kasus pelecehan seksual merupakan kejahatan terhadap keasusilaan yang menyerang fiisik korban secara langsung maupun tidak langsung, pelecehan seksual ini adalah perbuatan yang mengarah pada area seksualitasnya seseorang untuk memenuhi hawa nafsu sipelaku terhadap korban. Dalam kasus pelecehan seksual yang ingin dibahas oleh penulis yaitu ditemukan tiga orang remaja yang melakukan pelecehan seksual melalui live straming melalui aplikasi tiktok di salah satu parkiran mobil yang ada di warung kopi Peunayong hingga kasus tersebut viral dimedia sosial dan media massa. Berdasarkan keterangan dari KABID (kepala bidang) penegakan syariat islam Wilayatul Hisbah Kota Banda Aceh setelah dilakukannya pemeriksaan lebih lanjut para pelaku tersebut dinyatakan memenuhi unsur dan diberikan peringatan atau pembinaan. kasus pelecehan seksual yang viral tersebut ditangani dengan mudah serta efektif, apabila dibandingkan dengan beberapa kasus pelanggaran syariat islam lainnya yang tidak viral. Rumusan masalahnya ialah pertama. Bagaimana efektifitas penegakan hukum oleh Satpol PP dan WH Kota Banda Aceh terhadap penanganan kasus pelecehan seksual yang viral dimedia sosial dan media massa di Kota Banda Aceh.. Kedua, Bagaimana upaya yang dapat diberikan oleh Pemerintah Aceh kepada lembaga penegakan hukum untuk meminimalisir kendala-kendala dalam pemeriksaan. Penelitian ini dilakukan menggunakan pendekatan kualitatif menggunakan jenis penelitian empiris. Dari hasil penelitian didapatkan kesimpulan bahwa aparat penegak hukum Satpol PP dan WH Kota Banda Aceh menyatakan bahwa efektif dalam menangani kasus Pelecehan Seksual yang viral dan diungkapkan melalui media massa tersebut. Efektifnya penegakan hukum selama pemerikasaan berlangusng itu disebabkan oleh faktor dukungan dari netizen yang ikut melaporkan hal tersebut dengan cepat serta memudahkan penyidik dalam melakukan pemeriksaan akibat kasus yang mereka lakukan viral, Jika dibandingkan dengan kasus yang tidak viral aparat mengaku susah dalam menanganinya hingga penanganan yang diberikan terbilang kurang efektif. Hal itu disebabkan oleh beberapa faktor adapun faktornya adalah kurangnya sarana dan prasarana yang diberikan oleh pemerintah Aceh kepada lembaga penegakan hukum.
Pembentukan Karakter Religius dengan Pembiasaan Perilaku Religiusitas dalam Pendidikan Agama Islam di SMK Negeri 4 Agribisnis dan Agroteknologi Jayapura
Authors: Rahmat  , M. Anang Firdaus  , Muhammad Taslim  
Published: February 2025

Proses belajar mengajar Pendidikan Agama Islam (PAI) di SMK Negeri 4 Agribisnis dan Agroteknologi masih memberatkan pada pembelajaran klasikal, dimana guru memberikan materi pelajaran PAI hanya sebatas menyampaikan inti materi Pelajaran saja di dalam kelas. Sementara itu, pembentukan karakter religius peserta didik hendaknya Pelajaran PAI terdapat pengamalan materi dalam bentuk demonstrasi atau praktek ibadah.
Adapun tujuan dari penelitian tesis ini, sebagai berikut: (a) Memberikan gambaran dan deskripsi tentang proses pembentukan karakter religius dengan pembiasaan perilaku religi di SMK Negeri 4 Agribisnis dan Agroteknologi Jayapura, (b) Menguraikan kendala yang dihadapi dalam pembentukan karakter religius dengan pembiasaan perilaku religi, dan (c) Mendeskripsikan solusi untuk mengatasi kendala yang dihadapi dalam pembentukan karakter religius dengan pembiasaan perilaku religi.
Metode penelitian yang digunakan adalah kualitatif deskriptif dengan pendekatan keilmuan sosiologis, sedangkan pendekatan metodologi digunakan pendekatan fenomenologi.
Hasil penelitian; (1) Pelaksanaan pembiasaan dalam membentuk karakter religius peserta didik dilaksanakan secara terprogram berdasarkan buku panduan khusus tentang Penumbuhan Budi Pekerti. (2) Kendala yang dihadapi yaitu; (a). Faktor internal meliputi perilaku bawaan; (b) Faktor ekstern meliputi kurang maksimalnya pengondisian dan dukungan dari guru-guru, latar belakang pendidikan peserta didik, pola asuh orang tua, teman sebaya, media sosial dan sarana prasarana, (3) Solusi untuk mengatasi kendala pelaksanaan pembiasaan dalam membentuk karakter religius peserta didik, yaitu: (a) sosialisasi pentingnya pendidikan karakter; (b) tata tertib; (c) reward dan punishment (d) controlling; (e) penambahan sarana prasarana.
Tackling Sustainability in Today’s Building Climate
Authors: Gosav Cosmin-Ionuţ 
Published: February 2025

Abstract
The construction industry is composed of the entirety of our built environment, from small houses to apartment buildings, to bridges and offices and as such, it serves as the basis on which our society develops, providing context for our world. Since late 2019, with the start of the COVID-19 pandemic the world as we know it has suffered from a social, economical and political shift, as activities have halted in an attempt to stop the spread of the virus. Restrictions and regulations meant to guard our livelihood have had lots of unpredictable and unwanted consequences, and industries from across the globe, especially the building industry have deteriorated, devolved or diminished, resulting in a decrease in quality of life overall. This, combined with the effects of global warming accumulating over the years makes us really consider the importance of building sustainable and minimizing the impact of our lives over the medium we design and thrive. In this regard, the legislative bodies governing the European Union have given guidelines and suggestions on how and why everyone should build with efficiency in mind and trying to lessen the waste that the process of building produces. As such, from 2021 all new buildings must comply to the nZEB standard, meaning they have to be designed with sustainability as a key element. As new technology and engineering feats commence, how can architects adapt to this shift in the design paradigm? And how can this be achieved in underdeveloped countries, where there are many other factors which can be detrimental in the outcome of the built project?
Structural Response Analysis for RC Frame Structures Under Seismic Action
Authors: Bunea Georgiana , Atanasiu Gabriela Maria 
Published: February 2025

Abstract
This paper analyses the response of a set of RC frame structures, with different structural parameters, under seismic actions. The purpose is to observe how the structural response varies depending on the structural and seismic action parameters. For this analysis, four structural parameters were selected to be modified and each structure thus obtained was subjected to three seismic actions. In this study case, the structural response is given by the fundamental vibration period of the damaged structure Tf
, the maximum displacement dmax
and the inter-story drift ratio IDR. Two of these values, i.e. Tf
and IDR, are related directly to the post-seismic structural damage state, which is one of the most important indicators of the structural response.
Recommendations for Manufacturers of Mine Suspended Monorail Transportation Means in the Context of Entry the Technical Data Into the Aiding Configuration System
Authors: Tokarczyk Jarosław , Dudek Marek 
Published: February 2025

Abstract
The article presents recommendations that should be followed by the manufacturers of underground mine suspended monorail transportation means (auxiliary mine transport equipment), used on inclinations up to 45 degrees, in the context of using the technical data contained in the instructions for their entry into the Safe Trans Design (STD) database. Safe Trans Design system was developed by KOMAG Institute of Mining Technology in 2013. At the same year it was implemented in the mines of Jastrzębska Coal Company (JSW S.A.). Its purpose is to help (assist) designers of suspended monorail transportation system to carry out traction calculations. These calculations are required in the process of preparing documentation for the transportation system. Technical data included in the database, should contain information for: suspended monorail locomotives, brake trolleys, modular carrying sets (high-load beams), sets of hoists, cabins, and benches for movement of people, containers, and special wagons. Examples of generalized input data for the selected components of the suspended transportation unit (passenger cabin and suspended locomotive), in the context of their use in traction calculations, are presented. An example of importing the graphical load-carrying characteristic for suspended monorail locomotive, using digitalization and the CAD system (AutoCAD), is also presented.
Navigating Risks with ISO 31000 for A Sustainable Future: A Strategic Approach in The Indonesia Textile Industry
Authors: Yonatan Agnes Zefanya , Susanto Sani , Sukapto Paulus , Zagloel Teuku Yuri M. , Timotius Elkana 
Published: February 2025

Abstract
The dynamic changes across various industries are creating uncertainty, potentially leading to a state of risk. All industries are required to formulate mitigation actions for downside risks that have negative effects and leverage on upside risks, those with positive impacts. Despite various mitigation actions, only a few industries are capable of implementing risk management to address the dynamic changes. The refore, this qualitative research aimed to investigate the effectiveness of risk management guided by ISO 31000:2018 in navigating risks as a strategic approach for the industry to achieve a sustainable future. The investigation focused on the application of risk management in the textile manufacturing industry in Indonesia. The initial stages commenced with defining risk management scope, context, and criteria, followed by risk assessment consisting of identification, analysis, and evaluation, as well as formulating risk treatment. Heads of production, finance, and purchasing departments were selected as key informants through judgment sampling, where the results of semi-structured interviews served as primary data. Furthermore, operational, financial, strategic, technological, and informational risks were identified in the industry. The results showed that among the 109 downside and 20 upside risks, 10 were categorized as high-level and prioritized for handling. A total of 52 actions were determined as a treatment to navigate the high-level risks. The results showed that the ISO 31000:2018 guideline effectively addressed industry risk management needs, offering potential solutions to overcome the dynamic changes.