bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functionally graded optimisation of adsorption systems with phase change materials
Authors: Prado D. S. , Amigo R. C. R. , Hewson R. W. , Silva E. C. N. 
Published: May 2021

AbstractAdsorption phenomena are encountered in several engineering applications. One of its uses is in the storage and transport of gas in the form of adsorption tanks. The exothermic nature of the adsorption process decreases adsorption capacity presenting an impetus to understand the thermal characteristics of the gas storage process. Studies using mixtures of phase change materials and adsorbents in adsorption tanks demonstrate potential improvements in the adsorption capacity of the tanks. They also show that the distribution of phase change materials and adsorbent are important. Thus, this work presents two approaches for optimising the adsorbent domain. The first is to use a semi-analytic model to determine the best homogeneous material concentration for the adsorbent and phase change material for the vessel composition. The other is to use a 2D axisymmetric model to perform FGM optimisation to distribute material in the tank. Results for both models are presented and discussed for different conditions. The study shows that, for the cylindrical geometry, FGM optimisation is always, at least, marginally better than the homogeneous distribution from the semi-analytic model. However, FGM optimisation demands more computing time increases the complexity of implementation and results assembling. The semi-analytic approach is a possible alternative for optimising adsorption systems with phase change material mixed with adsorbents.
Corporate boards, interorganizational ties and profitability: the case of Japan
Authors: Raddant Matthias , Takahashi Hiroshi 
Published: May 2021

AbstractWe analyze the ties between 4000 Japanese corporations in the time period from 2004 until 2013. We combine data about the board composition with ownership relationships and indicators of corporate profitability. The board network exhibits some clustering, which can partly be explained by ownership relations, and a tendency to form ties to other corporations from the same sector. Connectivity in the board network (corporate board interlocks) and ownership network (shareholdings) does have an influence profitability. Firms that are linked to peers with above average profitability are more profitable than firms in other relationships. Hence, network effects partly explain why board interlocks and ownership ties are not always beneficial.
Molecularly imprinted polymers by epitope imprinting: a journey from molecular interactions to the available bioinformatics resources to scout for epitope templates
Authors: Pasquardini Laura , Bossi Alessandra Maria 
Published: May 2021

AbstractThe molecular imprinting of proteins is the process of forming biomimetics with entailed protein-recognition by means of a template-assisted synthesis. Protein-imprinted polymers (pMIPs) have been successfully employed in separations, assays, sensors, and imaging. From a technical point of view, imprinting a protein is both costly, for protein expression and purification, and challenging, for the preservation of the protein’s structural properties. In fact, the imprinting process needs to guarantee the preservation of the same protein three-dimensional conformation that later would be recognized. So far, the captivating idea to imprint just a portion of the protein, i.e., an epitope, instead of the whole, proved successful, offering reduced costs, compatibility with many synthetic conditions (solvents, pH, temperatures), and fine-tuning of the peptide sequence so to target specific physiological and functional conditions of the protein, such as post-translational modifications. Here, protein-protein interactions and the biochemical features of the epitopes are inspected, deriving lessons to prepare more effective pMIPs. Epitopes are categorized in linear or structured, immunogenic or not, located at the protein’s surface or buried in its core and the imprinting strategies are discussed. Moreover, attention is given to freely available online bioinformatics resources that might offer key tools to gain further rationale amid the selection process of suitable epitopes templates.
Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals?
Authors: te Lintel Hekkert Maaike , Newton Gary , Chapman Kathryn , Aqil Rehan , Downham Robert , Yan Robert , Merkus Daphne , Whitlock Gavin , Lane Charlotte A. L. , Cawkill Darren , Perrior Trevor , Duncker Dirk J. , Schneider Michael D. 
Published: May 2021

AbstractReducing infarct size (IS) by interfering with mechanisms for cardiomyocyte death remains an elusive goal. DMX-5804, a selective inhibitor of the stress-activated kinase MAP4K4, suppresses cell death in mouse myocardial infarction (MI), human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs), and 3D human engineered heart tissue, whose fidelity to human biology is hoped to strengthen the route to clinical success. Here, DMX-10001, a soluble, rapidly cleaved pro-drug of DMX-5804, was developed for i.v. testing in large-mammal MI. Following pharmacodynamic studies, a randomized, blinded efficacy study was performed in swine subjected to LAD balloon occlusion (60 min) and reperfusion (24 h). Thirty-six animals were enrolled; 12 were excluded by pre-defined criteria, death before infusion, or technical issues. DMX-10001 was begun 20 min before reperfusion (30 min, 60 mg/kg/h; 23.5 h, 17 mg/kg/h). At all times tested, beginning 30 min after the start of infusion, DMX-5804 concentrations exceeded > fivefold the levels that rescued hPSC-CMs and reduced IS in mice after oral dosing with DMX-5804 itself. No significant reduction occurred in IS or no-reflow corrected for the area at ischemic risk, even though DMX-10001 reduced IS, expressed in grams or % of LV mass, by 27%. In summary, a rapidly cleaved pro-drug of DMX-5804 failed to reduce IS in large-mammal MI, despite exceeding the concentrations for proven success in both mice and hPSC-CMs.
Arthroscopic modified Broström operation versus open reconstruction with local periosteal flap in chronic ankle instability
Authors: Mederake Moritz , Hofmann Ulf Krister , Ipach Ingmar 
Published: May 2021

Abstract
Introduction
The modified Broström operation (MBO) has found widespread use in the therapy of lateral chronic ankle instability (CAI). However, alternative surgical techniques like the open reconstruction using a periosteal flap (RPF) are still an important part of the surgical treatment of lateral CAI. Both procedures differ in terms of the reconstruction material used and the surgical procedure. Comparative studies on the surgical therapy of CAI are limited and generally refer to similar surgical procedures. Aim of this study was to compare the arthroscopic MBO and the RPF.

Materials and methods
We retrospectively analysed 25 patients with lateral CAI after a tear of the anterior talofibular ligament (ATFL). 14 patients received arthroscopic MBO and 11 patients received RPF. We compared the postoperative outcome between both groups with respect to subjective instability, the number of ankle sprains, pain, complications and follow-up operations as well as the American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score.

Results
Both surgical procedures resulted in a significant improvement in pain, in subjective instability, in the reduction in the frequency of ankle sprains and improvement in the AOFAS ankle-hindfoot score one year postoperatively. Three months postoperatively, the values for pain and instability of the MBO group were significantly better compared to the RPF. One year after the operation, these differences were evened out. Also in terms of complications and follow-up operations, no significant difference was found between the two procedures.

Conclusions
Both surgical procedures give very good results one year postoperatively in terms of pain, instability, function and complication rate. With significantly better results regarding pain and instability three months postoperatively, the MBO allows a faster recovery in patients operated with this technique.
Selective involution of thymic medulla by cyclosporine A with a decrease of mature thymic epithelia, XCR1+ dendritic cells, and epithelium-free areas containing Foxp3+ thymic regulatory T cells
Authors: Sawanobori Yasushi , Kitazawa Yusuke , Ueta Hisashi , Matsuno Kenjiro , Tokuda Nobuko 
Published: May 2021

AbstractImmunosuppressive drugs such as cyclosporine A (CSA) can disrupt thymic structure and functions, ultimately inducing syngeneic/autologous graft-versus-host disease together with involuted medullas. To elucidate the effects of CSA on the thymus more precisely, we analyzed the effects of CSA on the thymus and T cell system using rats. In addition to confirming the phenomena already reported, we newly found that the proportion of recent thymic emigrants also greatly decreased, suggesting impaired supply. Immunohistologically, the medullary thymic epithelial cells (mTECs) presented with a relative decrease in the subset with a competent phenotype and downregulation of class II major histocompatibility complex molecules. In control rats, thymic dendritic cells (DCs) comprised two subsets, XCR1+SIRP1α−CD4−and XCR1−SIRP1α+CD4+. The former had a tendency to selectively localize in the previously-reported epithelium-containing areas of the rat medullas, and the number was significantly reduced by CSA treatment. The epithelium-free areas, another unique domains in the rat medullas, contained significantly more Foxp3+thymic Tregs. With CSA treatment, the epithelium-free areas presented strong involution, and the number and distribution of Tregs in the medulla were greatly reduced. These results suggest that CSA inhibits the production of single-positive thymocytes, including Tregs, and disturbs the microenvironment of the thymic medulla, with a decrease of the competent mTECs and disorganization of epithelium-free areas and DC subsets, leading to a generation of autoreactive T cells with selective medullary involution.
Role of lung and gut microbiota on lung cancer pathogenesis
Authors: Zhao Yue , Liu Yuxia , Li Shuang , Peng Zhaoyun , Liu Xiantao , Chen Jun , Zheng Xin 
Published: May 2021

Abstract
Background
Lung cancer is the leading cause of cancer-related deaths worldwide (Ferlay et al., Int J Cancer 136:E359–386, 2015). In addition, lung cancer is associated with the highest mortality among all cancer types (Wu et al., Exp Ther Med 16:3004–3010, 2018). Previous studies report that microbiota play an important role in lung cancer. Notably, changes in lung and gut microbiota, are associated with progression of lung cancer. Several studies report that lung and gut microbiome promote lung cancer initiation and development by modulating metabolic pathways, inhibiting the function of immune cells, and producing pro-inflammatory factors. In addition, some factors such as microbiota dysbiosis, affect production of bacteriotoxins, genotoxicity and virulence effect, therefore, they play a key role in cancer progression. These findings imply that lung and gut microbiome are potential markers and targets for lung cancer. However, the role of microbiota in development and progression of lung cancer has not been fully explored.

Purpose
The aim of this study was to systemically review recent research findings on relationship of lung and gut microbiota with lung cancer. In addition, we explored gut–lung axis and potential mechanisms of lung and gut microbiota in modulating lung cancer progression.

Conclusion
Pulmonary and intestinal flora influence the occurrence, development, treatment and prognosis of lung cancer, and will provide novel strategies for prevention, diagnosis, and treatment of lung cancer.
Five-year follow-up of nivolumab treatment in Japanese patients with esophageal squamous-cell carcinoma (ATTRACTION-1/ONO-4538-07)
Authors: Satoh Taroh , Kato Ken , Ura Takashi , Hamamoto Yasuo , Kojima Takashi , Tsushima Takahiro , Hironaka Shuichi , Hara Hiroki , Iwasa Satoru , Muro Kei , Yasui Hirofumi , Minashi Keiko , Yamaguchi Kensei , Ohtsu Atsushi , Doki Yuichiro , Matsumura Yasuhiro , Kitagawa Yuko 
Published: May 2021

Abstract
Background
In the phase II ATTRACTION-1 study, nivolumab demonstrated a promising antitumor activity among Japanese patients with treatment-refractory advanced esophageal cancer. Here, we report the follow-up results of ATTRACTION-1 of > 5 years.

Methods
We enrolled patients with esophageal cancer that was refractory or intolerant to a standard chemotherapy. Then, nivolumab (3 mg/kg) was administered every 2 weeks. The primary endpoint was a centrally assessed objective response rate.

Results
Nivolumab was administered to 65 patients with esophageal squamous-cell carcinoma (ESCC). The centrally assessed objective response rate was 17.2%. The overall survival rates at 3 and 5 years were 10.9% and 6.3%, respectively. Three-year survivors tended to have more reduced target lesions. A total of 63.1% of the patients exhibited treatment-related adverse events, and no new safety signal was observed. Patients with select adverse events tended to have better overall survival than those without. No apparent chronological order was observed between the first response and the onset of select adverse events.

Conclusion
Our follow-up analysis of more than 5 years is currently the longest and is the first to demonstrate that nivolumab has long-term efficacy and safety for advanced ESCC.
Bose–Einstein Condensation for Two Dimensional Bosons in the Gross–Pitaevskii Regime
Authors: Caraci Cristina , Cenatiempo Serena , Schlein Benjamin 
Published: May 2021

AbstractWe consider systems of N bosons trapped on the two-dimensional unit torus, in the Gross-Pitaevskii regime, where the scattering length of the repulsive interaction is exponentially small in the number of particles. We show that low-energy states exhibit complete Bose–Einstein condensation, with almost optimal bounds on the number of orthogonal excitations.
Site-Monotonicity Properties for Reflection Positive Measures with Applications to Quantum Spin Systems
Authors: Lees Benjamin , Taggi Lorenzo 
Published: May 2021

AbstractWe consider a general statistical mechanics model on a product of local spaces and prove that, if the corresponding measure is reflection positive, then several site-monotonicity properties for the two-point function hold. As an application, we derive site-monotonicity properties for the spin–spin correlation of the quantum Heisenberg antiferromagnet and XY model, we prove that spin-spin correlations are point-wise uniformly positive on vertices with all odd coordinates—improving previous positivity results which hold for the Cesàro sum. We also derive site-monotonicity properties for the probability that a loop connects two vertices in various random loop models, including the loop representation of the spin O(N) model, the double-dimer model, the loop O(N) model and lattice permutations, thus extending the previous results of Lees and Taggi (2019).
The New Common
Authors: Jones Stephanie 
Published: May 2021

AbstractThis article describes a personal relationship to a common green space in a town in the United Kingdom during the lockdowns prompted by the Covid-19 pandemic in 2020–21. It considers the new meanings that are attaching to ‘commons’ as conceptual spaces and material places; and it links this consideration to the terms in which values and norms are being reassessed in the context of environmental crises.
Automatic approximation using asymptotically optimal adaptive interpolation
Authors: Plaskota Leszek , Samoraj Paweł 
Published: May 2021

AbstractWe present an asymptotic analysis of adaptive methods for Lp approximation of functions f ∈ Cr([a, b]), where $1\le p\le +\infty $
1
≤
p
≤
+
∞
. The methods rely on piecewise polynomial interpolation of degree r − 1 with adaptive strategy of selecting m subintervals. The optimal speed of convergence is in this case of order m−r and it is already achieved by the uniform (nonadaptive) subdivision of the initial interval; however, the asymptotic constant crucially depends on the chosen strategy. We derive asymptotically best adaptive strategies and show their applicability to automatic Lp approximation with a given accuracy ε.
Combination of Cu/ZnO Methanol Synthesis Catalysts and ZSM-5 Zeolites to Produce Oxygenates from CO2 and H2
Authors: Tariq Anisa , Ruiz Esquius Jonathan , Davies Thomas E. , Bowker Michael , Taylor Stuart H. , Hutchings Graham J. 
Published: May 2021

AbstractCu/ZnO methanol catalysts were deposited over several ZSM-5 acid zeolites to directly synthesise oxygenates (methanol and dimethyl ether) from a CO2/H2 feed. Catalysts were prepared by two different preparation methodologies: chemical vapour impregnation (CZZ-CVI) and oxalate gel precipitation (CZZ-OG). Chemical vapour impregnation led to Cu/ZnO being deposited on the zeolite surface, whilst oxalate gel precipitation led to the formation of Cu/ZnO agglomerates. For both sets of catalysts a higher concentration of mild and strong acid sites were produced, compared to the parent ZSM-5 zeolites, and CZZ-CVI had a higher concentration of acid sites compared to CZZ-OG. Nevertheless, CZZ-OG shows considerably higher oxygenate productivity, 1322 mmol Kgcat−1 h−1, compared to 192 mmol Kgcat−1 h−1 over CZZ-CVI (ZSM-5(50), 250 ℃, 20 bar, CO2/H2 = 1/3, 30 ml min−1), which could be assigned to a combination of smaller particle size and enhanced methanol mass transfer within the zeolites.
From in vitro research to real life studies: an extensive narrative review of the effects of balneotherapy on human immune response
Authors: Maccarone M. C. , Magro G. , Solimene U. , Scanu A. , Masiero S. 
Published: May 2021

Abstract
Purpose
The biologic mechanisms by which balneotherapy (BT) alleviates symptoms of different diseases are still poorly understood. Recently, preclinical models and clinical trials have been developed to study the effects of BT on the immune system. This review summarizes the currently available evidence regarding the effects of spa therapy on the immune response, to confirm the role of BT in the enhancement of immune system and open interesting research fields.

Methods
PubMed and Google Scholar were searched from 1997 up to June 2020, with search criteria including terms related to BT and immune system. We selected only in vitro research, randomized controlled trials (RCTs) or clinical trials.

Results
In vitro studies on human and animal samples have demonstrated that thermal waters exert anti-inflammatory and immunomodulatory effects. In particular, H2S donors seem to counteract the inflammatory processes in psoriatic lesions, arthritic fibroblast-like synoviocytes and chondrocytes, and regulate important factors implicated in osteoarthritis pathogenesis and progression. RCTs and clinical trials revealed, after BT, a reduction in circulating levels of pro-inflammatory molecules, such as TNF-α, IL-1β, and C-reactive protein, and an increase in anti-inflammatory molecules such as the IGF-1 growth factor especially in musculoskeletal diseases.

Conclusion
Further preclinical studies and RCTs could help to exploit BT in real life for preventive and therapeutic treatments.
Multi-task temporal convolutional networks for joint recognition of surgical phases and steps in gastric bypass procedures
Authors: Ramesh Sanat , Dall’Alba Diego , Gonzalez Cristians , Yu Tong , Mascagni Pietro , Mutter Didier , Marescaux Jacques , Fiorini Paolo , Padoy Nicolas 
Published: May 2021

Abstract
Purpose
Automatic segmentation and classification of surgical activity is crucial for providing advanced support in computer-assisted interventions and autonomous functionalities in robot-assisted surgeries. Prior works have focused on recognizing either coarse activities, such as phases, or fine-grained activities, such as gestures. This work aims at jointly recognizing two complementary levels of granularity directly from videos, namely phases and steps.

Methods
We introduce two correlated surgical activities, phases and steps, for the laparoscopic gastric bypass procedure. We propose a multi-task multi-stage temporal convolutional network (MTMS-TCN) along with a multi-task convolutional neural network (CNN) training setup to jointly predict the phases and steps and benefit from their complementarity to better evaluate the execution of the procedure. We evaluate the proposed method on a large video dataset consisting of 40 surgical procedures (Bypass40).

Results
We present experimental results from several baseline models for both phase and step recognition on the Bypass40. The proposed MTMS-TCN method outperforms single-task methods in both phase and step recognition by 1-2% in accuracy, precision and recall. Furthermore, for step recognition, MTMS-TCN achieves a superior performance of 3-6% compared to LSTM-based models on all metrics.

Conclusion
In this work, we present a multi-task multi-stage temporal convolutional network for surgical activity recognition, which shows improved results compared to single-task models on a gastric bypass dataset with multi-level annotations. The proposed method shows that the joint modeling of phases and steps is beneficial to improve the overall recognition of each type of activity.
Erfassung des Potenzials zur kognitiven Aktivierung über Unterrichtsmaterialien im Mathematikunterricht
Authors: Herbert Benjamin , Schweig Jonathan 
Published: May 2021

ZusammenfassungEine zentrale Voraussetzung der Unterrichtsforschung besteht darin, Unterrichtsmerkmale angemessen zu erfassen. Die Einschätzung des (gefilmten) Unterrichts durch geschulte Rater*innen gilt dabei als Königsweg, ist jedoch mit einem hohen organisatorischen und zeitlichen Aufwand verbunden. Im Rahmen dieses Artikels wird ein neu entwickeltes Erhebungsinstrument für das Unterrichtsqualitätsmerkmal des Potenzials zur kognitiven Aktivierung (PKA) vorgestellt. Das Instrument wurde für Mathematikunterricht zum Thema Quadratische Gleichungen entwickelt, basiert auf der gemeinsamen Auswertung aller Unterrichtsmaterialien einer Stunde durch geschulte Rater*innen und erfasst die von der Lehrperson schriftlich in den Unterricht getragenen Potenziale für kognitive Aktivierung. Die Validität der intendierten Interpretation als Indikator für das schriftlich in den Unterricht eingebrachte PKA einer Unterrichtstunde wird über einen argumentationsbasierten Ansatz untersucht und kann über verschiedene Evidenzen gestützt werden: Beispielsweise zeigt eine D‑Studie, dass das Instrument bereits von einer einzigen Rater*in zuverlässig erfasst werden kann. Zudem korreliert es substanziell mit einer auf Videoratings basierenden Messung des PKA.