bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peak Fat Oxidation During Submaximal Exercise Remains Consistent across Menstrual Cycle and Combined Oral Contraceptive Phases
Authors: Löfberg Ida E. , Karppinen Jari E. , Laatikainen-Raussi Iida , Ihalainen Johanna K. , Lehti Maarit , Hackney Anthony C. , Mikkonen Ritva S. 
Published: February 2025

ABSTRACT

Purpose
Substrate metabolism during exercise may vary across the menstrual cycle (MC) phases, likely due to estradiol (E2) and progesterone (P4). This study examined substrate metabolism during exercise in naturally menstruating (NoOC, n = 34) and women using combined oral contraceptives (COC, n = 19).

Methods
Participants were measured in a fasted state in the follicular (FOL) and luteal (LUT) phases, or the inactive (INACT) and active (ACT) phases of COC use. Serum E2 and P4 were assessed using immunoassays and body composition via bioimpedance. Peak fat oxidation (PFO) and FATMAX, the intensity eliciting PFO, were evaluated using indirect calorimetry. FATMAX was calculated using peak oxygen uptake (V̇O2PEAK), measured on the following day.

Results
PFO did not differ between FOL and LUT (0.40 ± 0.09 g·min-1 vs. 0.41 ± 0.10 g·min-1, p = 0.482) or INACT and ACT (0.48 ± 0.12 g·min-1 vs. 0.44 ± 0.11 g·min-1, p = 0.099). FATMAX showed no phase-related variation (NoOC: FOL 47.3 ± 15.7 % vs. LUT 47.7 ± 13.6 %, p = 0.727; COC: INACT 57.1 ± 12.3 % vs. ACT 52.5 ± 12.2 % p = 0.172). PFO was 0.08 g·min-1 (95 % confidence interval: 0.02 g·min-1–0.14 g·min-1, p = 0.010) and FATMAX 9.8 % (95 % CI: 1.0–8.7 %, p = 0.031) higher in the INACT vs. FOL. The difference in PFO persisted after adjusting for fat-free mass and V̇O2PEAK (p = 0.033) but was not significant after excluding an outlier from the COC group (p = 0.108).

Conclusions
PFO and FATMAX remained stable between MC and COC phases, suggesting no need to standardize measurements by cycle phase. However, higher PFO and FATMAX in the COC group during INACT compared to FOL suggests distinct effects of exogenous hormones on metabolism compared to endogenous hormones. Practitioners should consider these differences when assessing factors influencing substrate metabolism.
Vigorous Physical Activity Is Associated with White Matter Volume in Post-9/11 Veterans
Authors: Nowak Madeleine K. , Whitworth James W. , Fortenbaugh Francesca C. , Milberg William P. , Fortier Catherine B. , Salat David H. 
Published: February 2025

ABSTRACT
Trauma exposure is associated with declines in cardiovascular, cerebral, and mental health. Physical activity has been identified as a non-pharmacological treatment to mitigate these negative health outcomes in civilian populations with associated benefits to brain health. However, the relationship between physical activity and brain structure in Veterans remains unexplored. Studying this relationship is crucial to develop targeted interventions tailored to the unique experiences of Veterans.

Purpose
This study aimed to investigate the relationship of physical activity levels on white matter volume in post-9/11 Veterans.

Methods
The study consisted of post-9/11 Veterans enrolled in the Translational Research Center for TBI and Stress Disorders (TRACTS) longitudinal study at VA Boston Healthcare System. Participants were retrospectively categorized into two groups: a Vigorous group of Veterans who participated in vigorous-intensity physical activity (n = 84), and a No Vigorous group of Veterans who reported no participation of vigorous-intensity physical activity (n = 62). Physical activity was measured using the International Physical Activity Questionnaire (IPAQ), and Veterans underwent quantitative brain magnetic resonance imaging (MRI) to obtain regional white matter volumes.

Results
A cross-sectional analysis revealed trends of greater white matter volume throughout brain regions associated with cognitive functions and emotional regulation in the Vigorous group compared to the No Vigorous group. Following correction for multiple comparison, significant differences between groups were found in the right [p-corrected = 0.049] and left [ p-corrected = 0.049] precuneus. Furthermore, an interaction analysis showed that the difference in white matter volume between vigorous and non-vigorous activity groups was more pronounced in individuals with PTSD compared to those without PTSD.

Conclusions
These data offer new insights suggesting vigorous physical activity is associated with neural benefits in Veterans with PTSD.
The use of antipsychotics in the real-world clinical practice in Russia (based on the results of the EPIDEMICUS program)
Authors: Medvedev V. E. 
Published: February 2025

The optimization of antipsychotic therapy is an urgent issue not only in psychiatry, but in healthcare as a whole.Objective: to analyze the results of the non-interventional EPIDEMICUS epidemiological study of the real-world practice of the use of quetiapine (Seroquel®) during combined treatment and therapy switching in patients with various mental disturbances.Material and methods. Based on a special questionnaire, an analysis of the prescription of quetiapine and other antipsychotics by psychiatrists in 21 cities of Russia was carried out. The treatment data of 1264 patients aged 43.9±5.2 years were analyzed; the average duration of mental illness at the beginning of the study was 10.5 years.Results. In most cases, physicians preferred to switch to the quetiapine monotherapy, but in 10% of cases an antipsychotic was also added. According to the doctors, patients with schizophrenia most frequently required a therapy switch (46.3%). In bipolar affective disorder (BAD), one in three patients (30.8%) required therapy switch. For other mental disorders, doctors more frequently added quetiapine to the therapy (23.2%; p<0.001) or switched the previous therapy (12.1%). The significantly more frequent reasons given by doctors for switching from oneneuroleptic to another were the need to intensify antipsychotic effect (p<0.001) , to increase sedation (p<0.001) and to improve tolerability (p<0.001) . There is no recommended "overlap period" when switching from one medication to another. Changes in the therapy with mood stabilizers and anxiolytics were performed to enhance antipsychotic and sedative effects (p<0.001) and, as a tendency to improve tolerability. The concomitant administration of two or more antipsychotics could be due to both medical error and an attempt to overcome drug resistance.Conclusion. In the real-world clinical practice of domestic psychiatrists, at least one third of patients taking antipsychotics for various conditions (schizophrenia, bipolar disorder, etc.) require a switch or additional therapy. The reasons for therapy switching can be diagnostic errors, the choice of medication as well as insufficient efficacy or poor tolerability of the antipsychotics. Quetiapine (Seroquel®) is recognized in real-world clinical practice by psychiatrists as a highly effective and well-tolerated antipsychotic with a broad spectrum of activity that goes beyond the official indications.
Composición y estructura comunitaria de diatomeas epilíticas en la cuenca Vitor-Quilca-Chili, Arequipa, Perú
Authors: Coayla Pastor , Motta Cecilia , Blanco Saúl 
Published: February 2025

Las diatomeas han sido estudiadas por ser indicadoras de la calidad del agua de los ríos y su estructura comunitaria puede estar influenciada por diversos factores. En este trabajo estudiamos la comunidad de diatomeas epilíticas y su relación con variables ambientales en la cuenca Vitor-Quilca-Chili al extremo sur de Perú en junio y noviembre del 2022. Se identificaron 101 taxones, los géneros Nitzschia y Navicula presentaron el mayor número de taxones. El índice de Shannon identificó la comunidad de diatomeas más diversa en el río Chili (2,81) en junio y en el río Sumbay (3,22) en noviembre. El índice de Simpson identificó comunidades con moderada dominancia (0, 47) en el río Siguas en noviembre, aunque bastante uniforme según el índice de Pielou. Las variables como la conductividad eléctrica, caudal, pH y materia orgánica probablemente determinaron la estructura de la comunidad. Además, la riqueza de taxones fue mayor en noviembre (51) que en junio. Nuestro estudio también reveló valores superiores a lo registrado en su ambiente natural de deformidades en el contorno de las valvas de las diatomeas Cymbella excisa (12,11 %) y Diatoma tenuis (20, 89 %).
Reuse of agricultural drainage water and wastewater for crop irrigation in southeastern Algeria
Authors: Kouider Djouheina Boukehlifi , Athmani Houria , Bensefia Sofiane 
Published: February 2025

Abstract
Water resources are regarded as the primary impediment to proper human development in arid and desert regions, and the situation has been exacerbated by current climate change. The same phenomenon can be observed in the Ziban region of the Biskra wilaya, where agriculture consumes the most water resources. It is due to the increase in the size of reclaimed agricultural areas from year to year as the region’s urban centres expand, causing wastewater to be discharged into agricultural sewers and discharged into the Oued Djedi. However, during our field survey, we discovered that some farmers water their crops with drainage water mixed with wastewater. This study aims to determine how climate change is affecting the region, as well as the damage caused by watering crops with agricultural and sanitary drainage water. A statistical analysis of climatic parameters (mainly rainfall) and physiochemical parameters of drainage water at six sampling points in the Occidental Zab region was carried out. We measured nitrates, calcium hardness, chloride ions, nitrates, chemical oxygen demand (COD) and biochemical oxygen demand (BOD5). The results show a reduction in the total annual rainfall rate, from 208.6 mm in 1996 to 19 mm in 2017. As for drainage water analysis, the following results were noted: SO4
2− (mg/l) [545.45–3436.36], NO3
− (mg/l) [0.75–3.94], BOD5 (mg/l) [10–50], COD (mgO2/l) [14.12–72.25], Cl− (mg/l) [331.33–1692.16], Ca2+ (mg/l) [352.68–643.23], Mg2+ (mg/l) [120]. The study emphasises the importance of a comprehensive assessment of wastewater for agriculture, particularly because some farmers use it to water their crops, as well as the need for targeted interventions to mitigate potential challenges associated with potential damage. As a result, these findings can help decision-makers and local stakeholders establish wastewater filtration plants, improve farmers’ water use, and protect this valuable resource.
The crystal structure of 4-carboxy-2-oxobutan-1-aminium chloride, C5H10ClNO3
Authors: Wang Fengfeng , Zhang Caiyu , Wang Youyou , Luan Lin , Hu Xiaowen , Liu Yang 
Published: February 2025

Abstract
C5H10ClNO3, orthorhombic, Pbca (no. 61), a = 8.2012(1) Å, b = 11.2215(2) Å, c = 16.8339(3) Å, V = 1549.22(4) Å3, Z = 8, R
gt(F) = 0.0473, wR
ref(F
2) = 0.1331, T = 297 K.
Recycled Glass Powder Produced by Steel and Ceramic Milling as a Supplement to Portland Cement for More Sustainable Concrete
Authors: Likes Lauren , Markandeya Ananya , Zarei Ali , Mostafa Haider Md , Bollinger David , McCloy John , Nassiri Somayeh 
Published: February 2025

Abstract
This study demonstrates the successful use of eco-friendly recycled glass powders (RGPs) in mortar and concrete as pozzolanic substitute for portland cement. As part of the evaluation, two RGPs were produced by steel and ceramic ball mills, namely, RGP (SB) and RGP (CB), respectively. Also included in the experiment as a reference was a commercial ceramic ball-milled RGP. All three evaluated RGPs were found to be reactive pozzolans based on a series of reactivity test results, including a strength activity index of greater than 80 % on all ages of 7, 28, and 56 days in mortar and concrete. Multiple indicators, such as higher generated heat in pozzolanic reactivity testing by isothermal calorimetry and portlandite consumption, indicated ceramic milling could produce a more reactive glass pozzolan, perhaps from the alumina residue from ceramics milling media. However, the higher reactivity of RGP (CB) did not lead to a greater compressive strength when used in concrete. Furthermore, a color difference was not detected between RGP (SB) and RGP (CB) concrete specimens. This study shows that both steel and ceramic media are viable for RGP production based on pozzolanic reactivity, strength, electrical resistivity, and concrete color. Other factors, such as productivity and cost, should be considered when choosing the proper production method for RGP at the industrial scale.
Androgen producing oncocytic adrenocortical tumor in a 3.7-year-old female
Authors: Mans Kelli D , Elmahmudi Ghada A , Bedrnicek Jiri B , Cabrera Monina S 
Published: February 2025

Summary
We report a 3.7-year-old female who presented with clinical features of premature adrenarche. Workup revealed significantly elevated androgen levels and advanced bone maturation, prompting abdominal imaging that identified a 6.0 cm adrenal mass. She underwent unilateral adrenalectomy, and subsequent histopathology revealed a benign oncocytic adrenocortical adenoma. Post-adrenalectomy, androgen levels returned to pre-pubertal levels. A review of the literature on pediatric oncocytic adrenocortical neoplasms (OANs) is presented, and we add our case to the growing data of this rare disease in the pediatric population.

Learning points

A high index of suspicion is necessary when encountering a prepubertal child with clinical signs of hyperandrogenism and advanced bone age.

Oncocytic adrenocortical neoplasms are rare in children and are often benign, although they can be malignant or of uncertain malignant potential. Adrenalectomy is necessary for histopathological diagnosis and definitive treatment.

Pediatric oncocytic adrenocortical neoplasms are typically associated with elevated androgens; however, they can have a variety of other abnormal hormonal profiles at presentation. Return to normal hormonal levels is common post-adrenalectomy.
Las competencias interculturales de la comunidad académica del Tecnológico de Antioquia - Institución Universitaria
Authors: Ángel Rodríguez Dary Marcela , Ramírez Villegas Yaky Nayara , Bedoya Villa Daniel , Largo Gaviria Víctor Santiago , Serna Ledesma Ángel de Jesús 
Published: February 2025

The research exercise presented here is the result of the analysis carried out regarding the intercultural competences of the academic community - both teachers and students - in a Higher Education Institution in the city of Medellin: the Technological Institute of Antioquia - University Institution (TdeA). Thus, based on the framework of UNESCO's intercultural competences (2006), as well as the institution's PEI (2020) and Milton Bennett's ethno-relative cultural approach (1983), we designed a measurement instrument for intercultural sensitivity that reveals the degrees of interaction with diversity and cultural difference. In this instrument, we used widely spread memes on social media, highlighting mocking attitudes towards members of different social groups based on ethnic, racial, and gender differences, as well as neurocognitive and religious diversity.

The results demonstrate that the majority of the academic community is in stages of adaptation and acceptance of cultural differences, meaning high levels of intercultural sensitivity, which allows for considering appropriate intercultural competences for interacting with cultural diversity.
Espacio y fe en la Amazonía peruana. Sociedades religiosas y modelos de organización espacial
Authors: Novoa Goicochea Zaniel 
Published: February 2025

Este artículo presenta las relaciones entre geografía y religión basado en la hipótesis de que las prácticas religiosas de los colectivos humanos participan en la construcción del espacio y en la generación de modelos de organización espacial en la Amazonía peruana. El objetivo del presente estudio es describir las formas de ocupación del territorio y los modelos de organización del espacio que surgen a partir de dichas prácticas. Se desarrolla una aproximación teórica sobre la organización espacial con énfasis en los factores sociales y culturales, y se pone en práctica un proceso metodológico descriptivo apoyado en un amplio trabajo de campo, entrevistas, revisión bibliográfica, elaboración de cartografía y esquemas coremáticos. Todo esto contribuye a presentar las estructuras sociorreligiosas y los modelos de organización que corresponden a los tres casos de iglesias estudiadas. Los principales aportes se sintetizan en la confirmación de la relación entre geografía y religión, la comprensión de las vínculos entre la sociedad y el territorio ligadas con prácticas que se basan en el ejercicio de la fe, y la comprensión de los siguientes postulados y conceptos de la geografía de la religión: factores socioculturales, estructuras sociorreligiosas, paisajes religiosos, modelos de organización del espacio y otros.
El padre Joaquín García Sánchez, OSA. Un geógrafo innato
Authors: Bernex Weiss Nicole 
Published: February 2025

Este artículo presenta brevemente al insigne misionero agustino, geógrafo innato, profesor honorario de departamento de Humanidades de la Pontificia Universidad Católica del Perú, el padre Joaquín García Sánchez, OSA. Se relata su extraordinario itinerario geográfico desde su infancia caminando los paisajes de la cuenca minera de Sabero, León, España, hasta su llegada e inmersión en la Amazonía loretana. Constructor de puentes interculturales, el padre Joaquín era hombre de diálogos que se transformaron en obras (Centro de Estudios Teológicos de la Amazonía, Biblioteca Amazónica, Irapay, Shupihui, Kanatari, Monumenta Amazónica, entre otras). Durante más de 55 años se dedicó a vivir en, con y para la Amazonía desde todas sus diversidades biofísicas, socioculturales, económicas, ambientales y políticas. Sus estudios, escucha, generosidad y cercanía con los más relegados; su defensa de la paz y la democracia se conjugaron con el desarrollo de una pastoral indígena y ecoteología. Su impresionante horizonte geográfico integra las dimensiones vivas y vividas de los territorios amazónicos, las memorias y la interescalaridad. Con “Amazonium”, el padre Joaquín nos dejó una herencia científica, moral y alterética excepcional, invitándonos a hacer nuestro este sueño.
Transformaciones del paisaje y modos de vida: una perspectiva geohistórica en Dalcahue, Chiloé, Chile
Authors: Henríquez Olmedo Valentina , Barton Jonathan R. 
Published: February 2025

Este artículo explora las transformaciones del paisaje en la comuna de Dalcahue, Chiloé, y cómo estas son influenciadas a su vez por los cambios en los modos de vida o livelihoods de los chilotes desde el terremoto de 1960 hasta fines de la década 2010. Se aplica una metodología cualitativa basada en el análisis de entrevistas a adultos mayores que vivieron el período de tiempo del caso de estudio, quienes fueron testigos del abandono y aislamiento geográfico del archipiélago en la década de los 60 (y anteriores), así como de la irrupción de las actividades acuícolas, las cuales provocaron la expansión urbana y el abandono del campo. El artículo concluye que las modificaciones del paisaje se dan por los cambios de modos de vida de la sociedad chilota, así como también por agentes externos propios de la globalización, como la llegada de la industria salmonera y de miticultura.
Sport Participation Is Associated with Superior 10-Year Patient Acceptable Symptom State Achievement Following Contemporary Hip Arthroscopy for Femoroacetabular Impingement
Authors: Gilat Ron , Vogel Michael J. , Kazi Omair , Alvero Alexander B. , Nho Shane J. 
Published: February 2025

Background:
Sport participation has been associated with favorable outcomes following hip arthroscopy (HA) for femoroacetabular impingement (FAI) at short- and mid-term follow-up; however, few studies have evaluated the 10-year outcomes in this population. The purpose of this study was to compare patient-reported outcome measures (PROMs), the achievement of clinically significant outcomes, and reoperation-free survivorship between patients with and without regular preoperative sport participation who underwent HA for FAI and had a minimum of 10 years of follow-up.

Methods:
Data were prospectively collected for patients who underwent primary HA for FAI between January 2012 and September 2013. Patients who participated in weekly sport participation at the time of surgery (“athletes”) were matched 1:1 to patients who denied sport participation (“nonathletes”), controlling for age, sex, and body mass index (BMI). Preoperative and 10-year postoperative PROMs were collected, including the Hip Outcome Score Activities of Daily Living (HOS-ADL) and Sports (HOS-Sports) subscales, the modified Harris hip score (mHHS), and the visual analog scale for pain (VAS Pain) and satisfaction (VAS Satisfaction). Patient acceptable symptom state (PASS) achievement and reoperation-free survivorship were compared between the groups.

Results:
Sixty-four athletes were matched to 64 nonathletes of similar age, sex, and BMI (p ≥ 0.411). In the athlete group, 85.9% were recreational-level athletes. The groups had similar preoperative PROMs, except for the HOS-ADL subscale, where the athlete group demonstrated a higher preoperative score (67.8 ± 16.7 versus 59.9 ± 21.1, p = 0.029). Both groups demonstrated a significant improvement in all PROMs (p < 0.001) at the minimum 10-year follow-up10.3 ± 0.4 years). At the time of the final follow-up, the athlete group demonstrated significantly higher scores across all of the measured PROMs (p ≤ 0.036). Athletes showed a higher cumulative PASS achievement compared with nonathletes for the HOS-ADL subscale (73% versus 50%, p = 0.033), the HOS-Sports subscale (85% versus 61%, p = 0.010), the mHHS (69% versus 43%, p = 0.013), and the VAS Pain (78% versus 51%, p = 0.006). Reoperation-free survivorship frequencies were 87.5% and 82.8%, respectively (p = 0.504).

Conclusions:
Athletes who underwent contemporary HA for FAI showed superior PROMs and PASS achievement compared with nonathletes at the 10-year follow-up. Athletes and nonathletes showed reoperation-free survivorship frequencies of 87.5% and 82.8%, respectively.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.