bluuebunny/crossref_metadata_2025_split huggingface dataset:
MAIP: a web service for predicting blood‐stage malaria inhibitors
Authors: Bosc Nicolas , Felix Eloy , Arcila Ricardo , Mendez David , Saunders Martin R. , Green Darren V. S. , Ochoada Jason , Shelat Anang A. , Martin Eric J. , Iyer Preeti , Engkvist Ola , Verras Andreas , Duffy James , Burrows Jeremy , Gardner J. Mark F. , Leach Andrew R. 
Published: February 2021

AbstractMalaria is a disease affecting hundreds of millions of people across the world, mainly in developing countries and especially in sub-Saharan Africa. It is the cause of hundreds of thousands of deaths each year and there is an ever-present need to identify and develop effective new therapies to tackle the disease and overcome increasing drug resistance. Here, we extend a previous study in which a number of partners collaborated to develop a consensus in silico model that can be used to identify novel molecules that may have antimalarial properties. The performance of machine learning methods generally improves with the number of data points available for training. One practical challenge in building large training sets is that the data are often proprietary and cannot be straightforwardly integrated. Here, this was addressed by sharing QSAR models, each built on a private data set. We describe the development of an open-source software platform for creating such models, a comprehensive evaluation of methods to create a single consensus model and a web platform called MAIP available at https://www.ebi.ac.uk/chembl/maip/. MAIP is freely available for the wider community to make large-scale predictions of potential malaria inhibiting compounds. This project also highlights some of the practical challenges in reproducing published computational methods and the opportunities that open-source software can offer to the community.
Blind signal separation based on widely linear complex autoregressive process of order one
Authors: Li Jiong , Qin Yuan , Fan Menglan , Tang Xiaogang , Gao Lijuan , Chen Long , Feng Junhao 
Published: February 2021

AbstractIn this paper, the blind signal separation problem of complex baseband signal is addressed. A widely linear complex autoregressive process of order one is employed to represent the temporal structure of complex sources. We formulate a new contrast function by a convex combination of generalized autocorrelations and the statistics of the innovation. And the proposed contrast function is optimized by gradient method. Simulation results show that the proposed algorithm is better than the comparison algorithm in convergence speed and convergence accuracy.
Vitamin D status and blood pressure in children and adolescents: a systematic review of observational studies
Authors: Abboud Myriam , Al Anouti Fatme , Papandreou Dimitrios , Rizk Rana , Mahboub Nadine , Haidar Suzan 
Published: February 2021

Abstract
Background
Childhood hypertension is a growing public health problem. Simultaneously, hypovitaminosis D is widespread in this population and could be associated with hypertension. This study systematically reviewed the literature on the relationship between vitamin D status and blood pressure (BP) in children and adolescents.

Methods
Following the PRISMA guidelines, PUBMED, MEDLINE, CINAHL, EMBASE, Cochrane Library, and ClinicalTrials.gov and the gray literature without language or time restrictions were searched. We included observational studies, assessed their risk of bias, and extracted data on population characteristics, vitamin D status and BP measurements, and the association between the two variables. A narrative analysis of the studies was performed.

Results
In total, 85 studies were included. Prospective cohort studies showed no association between vitamin D and BP, and generally, they were flawed. Also, the majority of non-prospective cohort studies (cross-sectional, retrospective, case-control) did not report an association between vitamin D and BP. They were mostly flawed regarding BP measurement and adjusting to potential confounders.

Conclusion
The results on the relationship between vitamin D status and BP in children and adolescents varied between the studies, and mainly pointed towards lack of association.
Fractional calculus in the sky
Authors: Baleanu Dumitru , Agarwal Ravi P. 
Published: February 2021

AbstractFractional calculus was born in 1695 on September 30 due to a very deep question raised in a letter of L’Hospital to Leibniz. The prophetical answer of Leibniz to that deep question encapsulated a huge inspiration for all generations of scientists and is continuing to stimulate the minds of contemporary researchers. During 325 years of existence, fractional calculus has kept the attention of top level mathematicians, and during the last period of time it has become a very useful tool for tackling the dynamics of complex systems from various branches of science and engineering. In this short manuscript, we briefly review the tremendous effect that the main ideas of fractional calculus had in science and engineering and briefly present just a point of view for some of the crucial problems of this interdisciplinary field.
Container orchestration on HPC systems through Kubernetes
Authors: Zhou Naweiluo , Georgiou Yiannis , Pospieszny Marcin , Zhong Li , Zhou Huan , Niethammer Christoph , Pejak Branislav , Marko Oskar , Hoppe Dennis 
Published: February 2021

AbstractContainerisation demonstrates its efficiency in application deployment in Cloud Computing. Containers can encapsulate complex programs with their dependencies in isolated environments making applications more portable, hence are being adopted in High Performance Computing (HPC) clusters.Singularity, initially designed for HPC systems, has become theirde factostandard container runtime. Nevertheless, conventional HPC workload managers lack micro-service support and deeply-integrated container management, as opposed to container orchestrators. We introduce a Torque-Operator which serves as a bridge between HPC workload manager (TORQUE) and container orchestrator (Kubernetes). We propose a hybrid architecture that integrates HPC and Cloud clusters seamlessly with little interference to HPC systems where container orchestration is performed on two levels.
The effect of household storage tanks/vessels and user practices on the quality of water: a systematic review of literature
Authors: Manga Musa , Ngobi Timothy G. , Okeny Lawrence , Acheng Pamela , Namakula Hidaya , Kyaterekera Elizabeth , Nansubuga Irene , Kibwami Nathan 
Published: February 2021

Abstract
Background
Household water storage remains a necessity in many communities worldwide, especially in the developing countries. Water storage often using tanks/vessels is envisaged to be a source of water contamination, along with related user practices. Several studies have investigated this phenomenon, albeit in isolation. This study aimed at developing a systematic review, focusing on the impacts of water storage tank/vessel features and user practices on water quality.

Methods
Database searches for relevant peer-reviewed papers and grey literature were done. A systematic criterion was set for the selection of publications and after scrutinizing 1106 records, 24 were selected. These were further subjected to a quality appraisal, and data was extracted from them to complete the review.

Results and discussion
Microbiological and physicochemical parameters were the basis for measuring water quality in storage tanks or vessels. Water storage tank/vessel material and retention time had the highest effect on stored water quality along with age, colour, design, and location. Water storage tank/vessel cleaning and hygiene practices like tank/vessel covering were the user practices most investigated by researchers in the literature reviewed and they were seen to have an impact on stored water quality.

Conclusions
There is evidence in the literature that storage tanks/vessels, and user practices affect water quality. Little is known about the optimal tank/vessel cleaning frequency to ensure safe drinking water quality. More research is required to conclusively determine the best matrix of tank/vessel features and user practices to ensure good water quality.
Role of forest provisioning services to local livelihoods: based on relative forest income (RFI) approach in southwest Ethiopia coffee forest
Authors: Fekadu Ayehu , Soromessa Teshome , Warkineh Dullo Bikila 
Published: February 2021

Abstract
Background
This study provides empirical evidence, for the contribution of forest provisioning ecosystem services to the local communities done on the Afromontum rainforest of southwest Ethiopia which is endowed with many Fauna and Flora. The study may give some representative evidence for policy-maker on behalf of conservation of the area.

Methodology
This study was done with the approach of focus group discussion and in-depth interviews of the rural community in southwest Ethiopia coffee forest. The role of forest provisioning services analysis was made by relative forest income (RFI) procedure based on the stratification category of the local ethnics and newcomers.

Results
The overall result indicated that seventeen forest provisioning services collected by the community from natural forest, however income were varied in relation to demographic features, the income from forest for local communities shown too high to which contributes 90.85% of the total income and have a long history of the link between this livelihood and forest. While forest also provides a considerable income for the new resettled community coming from elsewhere in the area but we observed non- forest income were the main source of revenue for this community.

Conclusions
The traditional and the indigenous communities used for access to a finite resource and considered the resource harvested from the forest are the central part of their economy and the relationships between forests and people’s livelihoods particularly for this remote community were complementary. Then planning should take into conceder, in policy perceptive, for supporting this remote community for livelihood improvement and conservation of this natural forest.
Goal oriented error estimation in multi-scale shell element finite element problems
Authors: Bonney Matthew S. , Evans Richard , Rouse James , Jones Arthur , Kerfriden Pierre , Hamadi Maxime 
Published: February 2021

AbstractA major challenge with modern aircraft design is the occurrence of structural features of varied length scales. Structural stiffness can be accurately represented using homogenisation, however aspects such as the onset of failure may require information on more refined length scale for both metallic and composite components. This work considers the errors encountered in the coarse global models due to the mesh size and how these are propagated into detailed local sub-models. The error is calculated by a goal oriented error estimator, formulated by solving dual problems and Zienkiewicz-Zhu smooth field recovery. Specifically, the novel concept of this work is applying the goal oriented error estimator to shell elements and propagating this error field into the continuum sub-model. This methodology is tested on a simplified aluminium beam section with four different local feature designs, thereby illustrating the sensitivity to various local features with a common global setting. The simulations show that when the feature models only contained holes on the flange section, there was little sensitivity of the von Mises stress to the design modifications. However, when holes were added to the webbing section, there were large stress concentrations that predicted yielding. Despite this increase in nominal stress, the maximum error does not significantly change. However, the error field does change near the holes. A Monte Carlo simulation utilising marginal distributions is performed to show the robustness of the multi-scale analysis to uncertainty in the global error estimation as would be expected in experimental measurements. This shows a trade-off between Saint-Venant’s principle of the applied loading and stress concentrations on the feature model when investigating the response variance.
The incidence of pulmonary thromboembolism in COVID-19 patients admitted to the intensive care unit: a meta-analysis and meta-regression of observational studies
Authors: Ng Jun Jie , Liang Zhen Chang , Choong Andrew M. T. L. 
Published: February 2021

AbstractObjectivesCoronavirus disease 2019 (COVID-19) infection is associated with a prothrombotic state. We performed a meta-analysis of proportions to estimate the weighted average incidence of pulmonary thromboembolism (PTE) in COVID-19 patients who were admitted to the intensive care unit (ICU).MethodsWe searched various medical databases for relevant studies from 31 December 2019 till 30 September 2020. We included observational studies that reported the incidence of PTE in COVID-19 patients admitted to the ICU. We extracted data related to study characteristics, patient demographics, and the incidence of PTE. Risk of bias was assessed by using the ROBINS-I tool. Statistical analysis was performed with R 3.6.3.ResultsWe included 14 studies with a total of 1182 patients in this study. Almost all patients in this meta-analysis received at least prophylactic anticoagulation. The weighted average incidence of PTE was 11.1% (95% CI 7.7% to 15.7%,I2= 78%, Cochran’sQtestP< 0.01). We performed univariate and multivariate meta-regression, which identified the proportion of males as a significant source of heterogeneity (P= 0.03, 95% CI 0.00 to − 0.09)ConclusionThe weighted average incidence of PTE remains high even after prophylactic anticoagulation. PTE is a significant complication of COVID-19 especially in critically ill patients in the ICU.
A feasibility study to assess Imbrasia belina (mopane worm) sensitisation and related respiratory health outcomes in a rural community in Gwanda district, Zimbabwe
Authors: Ndlovu Vuyelwa , Chimbari Moses , Sibanda Elopy , Ndarukwa Pisirai 
Published: February 2021

Abstract
Background
Allergic diseases are considered to be some of the fastest growing chronic conditions in Africa. Of concern is the paucity of knowledge about the local environment and its role in allergic disease development. In response to this, we explored whether Imbrasia belina, a popular indigenous edible insect commonly known as mopane worm, is a potential allergen of clinical and public health significance in Zimbabwe. This study was intended to assess the plausibility and feasibility of this hypothesis with a view to evaluate the insect’s health impact in a larger study.

Methods
The study participants included male and female villagers aged 10 years and above in Gwanda district, Zimbabwe. Eligible participants who completed the household questionnaire were referred to the local clinic for skin prick tests and to measure lung function and allergic airway inflammation. Allergen sensitisation patterns were evaluated using 10 different inhalant allergen extracts including an in-house preparation of mopane worm. Lung function was measured with a Koko Legend spirometer, and fractional exhaled nitric oxide levels (FeNO) (NIOX VERO) were measured in participants with at least one abnormal spirometric parameter. Data was analysed using Stata version 13 software.

Results
Of the 46 eligible participants that completed the household questionnaire, 17 went to the clinic giving a response rate of 37%. The majority who completed the questionnaire were adults (91%) and the children (9%) were all female. The prevalence of sensitisation to Imbrasia belina was 50%, and the prevalence ranged from 22 to 72% for the other allergens including cockroach, mosquito and house dust mites. The data collection tools were safe and well tolerated by participants with no adverse events reported. Self-reported respiratory symptoms, abnormal lung function and elevated FeNO were recorded amongst participants sensitised to mopane worm.

Conclusion
Pre-defined feasibility criteria were met with the exception of a lower than expected response rate for clinic data collection in this pilot study. For the main study, modifying the sampling strategy and applying more consistent community engagement will improve the response rates.
Importance of immunoglobulin therapy for COVID-19 patients with lymphocytopenia
Authors: Nabih Heba K. 
Published: February 2021

Abstract
Background
The global coronavirus disease 2019 (COVID-19) was announced as pandemic by the World Health Organization (WHO). With the increased number of infected and dead victims daily all over the world, it becomes necessary to stop or overcome its rapid spread.
Main body
Although the production of vaccine or even specified effective anti-virus may take about six months to a year, intravenous immunoglobulin (IVIg) may be clinically used as a safe treatment to save and improve the quality of life of patients with a variety of immunodeficiency diseases such as lymphocytopenia, which is a common clinical feature in COVID-19.

Conclusion
Through the current review, it was concluded that this passive immunization may promote the immunity to better fight against the virus, so the survival of the patients could be kept longer. The efficacy of immunotherapy with IVIg would be greater if the immune IgG antibodies were collected from convalescent plasma therapy.
Diagnostic efficiency of PET/CT in patients with cancer of unknown primary with brain metastasis as initial manifestation and its impact on overall survival
Authors: Mohamed Dina Moghazy , Kamel Hanaa Ahmed 
Published: February 2021

Abstract
Background
Carcinoma of unknown primary (CUP) is a diagnostic and therapeutic challenge; correct diagnostic approach results in better outcomes in patients with brain metastasis. Whole body 18 F-FDG PET/CT is a helpful modality to detect the origin of primary tumor and assess metastasis in the rest of the body. We assessed the value of PET/CT in detection of unknown primary in 39 patients with brain metastases as initial presentation and detected its impact on their overall survival.

Results
PET/CT could correctly detected the primary tumor in 49% of patients which occurred mainly in the lung, 63% of patients had additional extracerebral metastatic sites mostly in lymph nodes. Specificity, sensitivity, and accuracy of PET/CT in CUP patients were 95%, 79%, and 87%, respectively. No significant difference was noticed in estimated overall survival time between patients with an identified primary tumor and patients with unidentified primary tumor.

Conclusion
PET–CT was a helpful non-invasive imaging modality in detecting primary in CUP patients with metastatic brain lesion. It helped in the diagnosis of unexpected extracerebral metastatic lesions. However, the identification of the primary tumor by PET/CT has no significant prognostic effect on patient overall survival.
Breast cancer in dense breasts: comparative diagnostic merits of contrast-enhanced mammography and diffusion-weighted breast MRI
Authors: Anwar Reham , Farouk Mohamed Amr , Abdel Hamid Wafaa Raafat , Abu El Maati Amal Amin , Eissa Hanan 
Published: February 2021

Abstract
Background
The study was done to compare the value of contrast-enhanced mammography and diffusion-weighted breast MRI in dense breast screening and accurate detection of the breast cancer with correlation of the findings to the histopathological results.
The study included 32 female patients having suspicious breast lesions and underwent digital mammography then scheduled for CESM and MRI DW imaging technique. The imaging findings were correlated to the histopathological findings.

Results
The study was conducted on 40 breast lesions in 32 female patients having dense breasts; they were classified by the digital mammography into ACR C (59.4%) and ACR D (40.6%). By CESM, there were twenty three lesions (57.5%) as mass lesions and thirteen lesions (32.5%) as non-mass lesions. Four lesions (10%) showed no contrast enhancement. According to the lesion characteristics in diffusion-weighted imaging, the breast lesions were classified into thirty three lesions (82.5%) with restricted diffusion and seven lesions (17.5%) with non-restricted diffusion. The study showed a cutoff ADC value to detect the malignant lesions in the dense breasts ≤ 1.1 × 10-3 s/mm2 at b value of 1000 s/mm2 with a sensitivity of 96.77%, specificity of 66.67%, PPV of 96.77%, NPV of 55.55%, and an overall total accuracy of 92.5%.
On comparing the diagnostic accuracy of the CESM to that of the DW MRI, the sensitivity of DW MRI (96.77%) was higher than that of CESM (90.32%). The specificity of DW MRI (66.67%) was higher than that of CESM (33.33%). Total accuracy of DW MRI was higher than that of CESM; they were 90% and 77.5%, respectively. Also, PPV and NPV of DW MRI were 90.91 and 85.71% as compared with 82.35 and 50.00% in CESM, respectively. When comparing the sensitivity of CESM to DW MRI in the detection of multiple breast lesions, they were 88.8 and 100%, respectively.

Conclusion
CESM is a useful technique in identification of hidden lesions in mammographically dense breasts. DW MRI is a fast, unenhanced modality that can be used as a breast cancer screening modality. CESM and DWI demonstrated good overall diagnostic accuracy in dense breast patients; however, DW MRI has a higher diagnostic accuracy than CESM for the detection of malignant breast lesions and their multiplicity.
Pulmonary veno-occlusive disease: a rare and enigmatic cause of pulmonary hypertension—a case report
Authors: Karmakar Angan , Bhakat Biva 
Published: February 2021

Abstract
Background
Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension characterized by remodelling of the pulmonary venules. PVOD and pulmonary arterial hypertension share similar clinical presentation. It is important to differentiate between these two conditions as PVOD carries a worse prognosis and life-threatening pulmonary oedema may occur following the initiation of conventional therapy.

Case presentation
We are reporting a case of pulmonary hypertension in a middle-aged lady who presented with hemoptysis and features of right heart failure. After extensive work up, no definite aetiology of pulmonary hypertension could be found out. Standard therapy did not cause any symptomatic improvement. After right heart catheterization, we got pre capillary pulmonary hypertension and along with typical findings in HRCT scan of thorax we established PVOD. We did not try lung biopsy as the procedure often lands up with complications. As we could not arrange for lung transplant we eventually lost the patient.

Conclusions
High suspicion and thorough systematic evaluation helped us to diagnose PVOD in this case. Thus, early diagnosis should be the primary aim in suspected cases of PVOD so that we can prepare for lung transplant at the earliest.