bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural Amino Acid L‐Phenylalanine Coordinated Zirconocene Complex as Bifunctional Catalyst for the Synthesis of 1,5‐Benzothiazepines
Authors: Yang Mingming , Guo Yingying , Zhang Xue‐Peng , Sun Huaming , Wang Yanyan , Zhang Weiqiang , Wu Ya , Jian Yajun , Gao Ziwei 
Published: December 2021

AbstractTaken the synthesis of 1,5‐benzothiazepines via the condensation between o‐aminothiophenol with ynones as a paradigm, novel mode of IVB metal based bifunctional catalysis in Lewis acidic‐Brønsted basic (LA‐BB) mode, as well as the effective evidence for how the two catalytic sites interact with substrates has been realized and provided respectively. Specifically, the bifunctional catalyst Cp2Zr[OCOCH(NH2)CH2C6H5]2 was formed through in situ coordination between Cp2ZrCl2 and natural amino acid L‐phenylalanine, which was elucidated by 1H NMR experiment and ESI‐MS analysis. Further control experiment reveals that the excellent catalytic efficiency can attribute to coexistence of Zr (IV) center and Brønsted basic NH2 group contained amino acid ligand. More importantly, with the aid of in situ ESI‐MS, the first catalyst‐substrate adduct for IVB metallocene (IV) catalyst was detected, indicating the Lewis acidic catalytic mode of Zr (IV) center on O atom of ynone. Meanwhile, DFT studies indicated that the true catalytic species presumably be zirconocene (IV) bearing both a bidentate and mono‐dentate carboxylate ligand.
Direct Electromembrane Extraction‐Based Mass Spectrometry: A Tool for Studying Drug Metabolism Properties of Liver Organoids
Authors: Skottvoll Frøydis Sved , Aizenshtadt Aleksandra , Hansen Frederik André , Martinez Mikel Amirola , Andersen Jannike Mørch , Bogen Inger Lise , Kutter Jörg P. , Pedersen‐Bjergaard Stig , Lundanes Elsa , Krauss Stefan , Wilson Steven Ray 
Published: December 2021

AbstractThis work introduces a strategy for organoid analysis ‐ direct Electromembrane Extraction based Mass Spectrometry (dEME‐MS) – for coupling liver organoids with mass spectrometry (MS). dEME‐MS comprises electrophoresis of selected small molecules from a culture chamber across an oil membrane, and to a MS compatible solution. This enables clean micro‐extraction of drugs and their metabolites as produced in the liver organoids to capillary liquid chromatography‐mass spectrometry. Applying dEME‐MS, proof‐of‐concept of directly measuring methadone metabolism is demonstrated on adult liver organoids. With 50 liver organoids and 1 μM methadone, methadone metabolism was monitored from 0 to 24 hours (11 time points). All analytes had <0.4 % variance in retention times with >100 measurements. dEME‐MS is capable of automated and selective monitoring of drug metabolism in liver organoids, and could serve as a valuable tool for automated drug discovery efforts.
Two tetranuclear Cu2Ln2 (Ln = Dy, Tb) heterometallic complexes: Structure, solution behavior, and magnetic properties
Authors: Yu Shui , Zhang Qin‐Hua , Zhu Jingru , Wei Fengli , Liu Dongcheng , Hu Huancheng , Zou Hua‐Hong , Liang Yuning , Liang Fupei , Chen Zilu 
Published: December 2021

AbstractTwo tetranuclear 3d–4f heterometallic complexes [Cu2Ln2(NO3)4(OAc)2L4] (Ln = Dy 1, Tb 2) were obtained under solvothermal reactions of 1‐amino‐propan‐2‐ol (HL) with [Cu2(OAc)4(H2O)2] and Ln (NO3)3·5H2O. The structural analyses confirmed a centrosymmetric Z‐shaped skeleton for them with the peripheral positions occupied by two Cu (II) ions. The neighboring two lanthanide ions, as well as the neighboring ions of Ln (III) and Cu (II), are all double‐bridged through two O atoms. The detailed dynamic magnetic investigation showed slow magnetic relaxation behaviors for both complexes with an energy barrier of 1.35(2) and 2.02(4) K for 1 and 2, respectively. Furthermore, it revealed from the electrospray mass spectrometry (ESI‐MS) that complexes 1 and 2 easily undergo dimerization in solution.
Ground penetrating radar surveys in the archaeological area of Augusta Bagiennorum: Comparisons between geophysical and archaeological campaigns
Authors: Colombero Chiara , Comina Cesare , Rocchietti Deborah , Garbarino Gian Battista , Sambuelli Luigi 
Published: December 2021

AbstractGeophysical methods, and particularly ground penetrating radar (GPR), have been increasingly applied as a preliminary mapping tool to guide archaeological excavations. Direct comparisons between geophysical and archaeological features are however not always systematically performed given the different time spans, covered areas, acquisition and processing approaches of the surveys. A critical comparison between geophysical and archaeological results is here proposed on a test site within the archaeological area of Augusta Bagiennorum (NW Italy). Three rectangular sectors covering an area of approximately 2325 m2 were investigated with high‐density GPR profiles and compared with both historical and new archaeological excavations. The GPR amplitude and attribute analyses highlight the effectiveness of geophysical prospections in identifying buried linear (i.e., walls) and localized (e.g., pillars or columns) archaeological remains. The recent archaeological excavations fully confirm the interpretation of the GPR results. Historical archaeological trenches, filled with coarse material after the excavation, are also found to generate strong anomalies in the GPR amplitude, similar to the ones of the buried structures, but with irregular contours and oblique orientations with respect to Roman remains. The GPR prospections also highlight interesting buried elements in unexplored areas, supporting important archaeological interpretations about the spatial configuration of the Roman city. The results help to recognize sectors with significant and well‐preserved buried remains that can be brought to light in the future to promote heritage conservation and enhancement at the site.
Internet of things‐enabled photomultiplier tube‐ and smartphone‐based electrochemiluminescence platform to detect choline and dopamine using 3D‐printed closed bipolar electrodes
Authors: Bhaiyya Manish , Kulkarni Madhusudan B. , Pattnaik Prasant Kumar , Goel Sanket 
Published: December 2021

AbstractThere is a growing demand to realize low‐cost miniaturized point‐of‐care testing diagnostic devices capable of performing many analytical assays. To fabricate such devices, three‐dimensional printing (3DP)‐based fabrication techniques provide a turnkey approach with marked precision and accuracy. Here, a 3DP fabrication technique was successfully utilized to fabricate closed bipolar electrode‐based electrochemiluminescence (ECL) devices using conductive graphene filament. Furthermore, using these ECL devices, Ru(bpy)32+/TPrA‐ and luminol/H2O2‐based electrochemistry was leveraged to sense dopamine and choline respectively. For ECL signal capture, two distinct approaches were used, first a smartphone‐based miniaturized platform and the second with a photomultiplier tube embedded with the internet of things technology. Choline sensing led to a linear range 5–700 μM and 30–700 μM with a limit of detection (LOD) of 1.25 μM (R2 = 0.98, N = 3) and 3.27 μM (R2 = 0.97, N = 3). Furthermore, dopamine sensing was achieved in a linear range 0.5–100 μM with an LOD = 2 μM (R2 = 0.99, N = 3) and LOD = 0.33 μM (R2 = 0.98, N = 3). Overall, the fabricated devices have the potential to be utilized effectively in real‐time applications such as point‐of‐care testing.
A highly selective fluorescence and absorption sensor for rapid recognition and detection of Cu2+ ions in aqueous solution and film
Authors: Zhong Tianyuan , Jiang Nan , Li Chen , Wang Guang 
Published: December 2021

AbstractA fluorescence and absorption chemosensor (SAAT) based on 5‐(hydroxymethyl)‐salicylaldehyde (SA) and o‐aminothiophenol (AT) was designed and synthesized. SAAT in DMSO–HEPES (20.0 mM, v/v, 1:99, pH = 7.0) solution shows a highly selective and sensitive absorption and an ‘on–off’ fluorescence response to Cu2+ ions in aqueous solutions over all other competitive metal ions including Na+, Ag+, Ba2+, Ca2+, Cd2+, Mg2+, Zn2+, Cr3+, Al3+, Hg2+, K+, Mn2+, Ni2+, Sr2+, Tb3+ and Co2+. SAAT exhibits ratiometric absorption sensing ability for Cu2+ ions. Importantly, SAAT also can sense Cu2+ ions using fluorescence quenching, the fluorescence intensity of SAAT showed a good linear relationship with Cu2+ concentration, and the detection limit of Cu2+ was 0.34 μM. The results of Job's plot, Benesi–Hildebrand plot, mass spectra, and density functional theory calculations confirmed that the selective absorption and fluorescence response were attributed to the formation of a 1:1 complex between SAAT and Cu2+. SAAT in test film could identify Cu2+ in water samples using the intuitive fluorescence colour change under a UV lamp. SAAT has great application value as a selective and sensitive chemosensor to discriminate and detect Cu2+ ions.
Curcuma longa and curcumin affect respiratory and allergic disorders, experimental and clinical evidence: A comprehensive and updated review
Authors: Memarzia Arghavan , Saadat Saeideh , Behrouz Sepideh , Boskabady Mohammad Hossein 
Published: December 2021

AbstractCurcuma longa and its constituents, mainly curcumin, showed various of pharmacological effects in previous studies. This review article provides updated and comprehensive experimental and clinical evidence regarding the effects of C. longa and curcumin on respiratory, allergic, and immunologic disorders. Using appropriate keywords, databases including PubMed, Science Direct, and Scopus were searched until the end of October 2021. C. longa extracts and its constituent, curcumin, showed the relaxant effect on tracheal smooth muscle, which indicates their bronchodilatory effect in obstructive pulmonary diseases. The preventive effects of extracts of C. longa and curcumin were shown in experimental animal models of different respiratory diseases through antioxidant, immunomodulatory, and anti‐inflammatory mechanisms. C. longa and curcumin also showed preventive effects on some lung disorders in the clinical studies. It was shown that the effects of C. longa on pulmonary diseases were mainly due to its constituent, curcumin. Pharmacological effects of C. longa extracts and curcumin on respiratory, allergic, and immunologic disorders indicate the possible therapeutic effect of the plant and curcumin on these diseases.
The impact of symptom screening on survival among patients with cancer across varying levels of pre‐diagnosis psychiatric care
Authors: Sutradhar Rinku , Li Qing , Kurdyak Paul , Barbera Lisa 
Published: December 2021

AbstractBackgroundPatients diagnosed with cancer often experience considerable challenges with mental health, and those who had more intense psychiatric care prior to their cancer diagnosis have a higher risk of mortality. As prior research demonstrated a survival benefit among patients screened for symptoms using the Edmonton symptom assessment system (ESAS), this study aims to examine the association between being ESAS‐screened and the risk of mortality across varying intensity levels of pre‐diagnosis psychiatric care utilization.MethodsWe conducted a retrospective matched cohort study using population‐wide administrative databases. All patients diagnosed with cancer in Ontario, Canada, from January 2007 to December 2015 were identified. Propensity score matching was used to pair ESAS‐screened individuals to those not screened. Pairs were also hard matched on a pre‐diagnosis psychiatric care utilization gradient. A multivariable Cox proportional hazards regression model was implemented to estimate the association between ESAS and mortality, for each intensity level of pre‐diagnosis psychiatric care.ResultsThe matched cohort consisted of 119,806 patient pairs (ESAS‐screened and not screened), of whom 54,468 (45.5%) pairs had prior outpatient psychiatric care and 2249 (1.8%) pairs had experienced emergency department visits or had been hospitalized for psychiatric care. Overall being exposed to ESAS was significantly associated with a 51% decrease in the hazard of mortality (HR 0.49, 95%CI 0.48–0.50, p‐value <0.0001). This association was similar across all levels of prior psychiatric use, however, there was no evidence of a differential impact.ConclusionIn addition to routinely monitoring symptom severity, including depression, among patients with cancer, it is also important to identify those with preexisting psychiatric comorbidities at the time of diagnosis. This information can be used to ensure that timely and appropriate psycho‐oncology services and psycho‐social supports are offered to help the patient and their family cope during the cancer disease trajectory.
Effects of group logotherapy on mood and function of locally advanced prostate cancer patients
Authors: Arefpour Amir Mohammad , Mahdavi Hoda 
Published: December 2021

AbstractPatients with prostate cancer who receive systemic androgen deprivation therapy (ADT) and local treatments have a high likelihood to experience depression, anxiety and fatigue. The present study aimed to determine the effects of Frankl's group logotherapy sessions on alleviating these symptoms in individuals with moderate‐ to high‐risk prostate cancer who were receiving pelvic radiotherapy. A quasi‐experimental study with pretest–post‐test was conducted in which 30 patients were assigned either to the experimental (n = 15) or to the control (n = 15) group. The implicated research instruments were as follows: Beck's Depression Inventory, Beck's Anxiety Inventory, Okayama et al.’s Cancer Fatigue Scale and Luthans' Psychological Capital Questionnaire. The results of the ANCOVA showed that logotherapy significantly affected anxiety (F = 42.51, p < 0.001), depression (F = 39.36, p < 0.001), cancer fatigue (F = 16.54, p < 0.001) and psychological capital (F = 39.86, p < 0.001) in the experimental group compared to the control group, indicating that logotherapy sessions with an emphasis on meanings, aims and values of life, when accompanied by peer interaction, can improve mood and function as well as contributing to positive psychological capital in intermediate and high‐risk prostate cancer patients during their treatments.
State‐level coordination for community college student success
Authors: Godin Eric , Bishop Brandon 
Published: December 2021

AbstractHigher education governance of community colleges is understudied. Driving an increased focus on community college coordination and oversight at the state level are the role of access from dual enrollment to adult learners, the need to smooth the transfer function of community colleges, jobs requiring educational attainment beyond high school, and reorganization of higher education governance to assist in achieving state attainment goals. This article addresses three topics relevant to state‐level governance of community colleges. First, it explains the various types of state‐level community college coordination (e.g., governing, coordination, association). Second, it highlights results from a State Higher Education Executive Officers Association's (SHEEO) survey on the functions of state‐level community college governing boards, coordinating boards, and associations. Third, it offers conclusions from the survey results and suggestions for action by community college practitioners and researchers.
Building community college federal advocacy
Authors: Baime David 
Published: December 2021

AbstractThis chapter describes and documents anticipated areas of federal community college advocacy. Changes in Congressional behavior are described with specific illustrations of federal legislation, specifically the Higher Education Act. Discussion on the role of the college president and CEO in advocacy focuses on the role of the president and the necessity to be vocal in federal relations. The article offers anticipated issues community college leaders need to be aware of including federal student aid, outcomes and return‐on‐investment, workforce education, innovation and institutional regulation, and the role of community colleges in civic education and cultural awareness. The chapter serves as a capstone for the volume and call to action for community college federal advocacy.
Modelling and optimization of the extrusion process in a snack of barley/corn and nutritional evaluation of the optimized product
Authors: Román‐Gutiérrez Alma Delia , Barrera‐Barrera Diana Isela , Morales‐Sánchez Eduardo , Castro‐Rosas Javier , Gómez‐Aldapa Carlos Alberto , Falfán‐Cortés Reyna Nallely , Rodríguez‐Marín Maria Luisa , Guzmán‐Ortiz Fabiola Araceli 
Published: December 2021

AbstractBackground and objectivesMost of the snacks in the market contain a single cereal and show nutritional deficiencies. The aim of the study was to optimize the conditions of the extrusion process for a snack with barley/corn mix and their physicochemical evaluation, amino acid content, protein digestibility, and resistant starch as a healthy snack.FindingsThe regression model indicated that the variables water absorption index, water solubility index, and hardness can be explained by the models. Expansion index showed no significant effect. The optimal conditions of the process of extrusion were feed moisture 38%, die temperature 130°C, and barley/corn mix 50:50. An unflavored snack with 392.11 kcal/100 g was obtained, considering it is flavored, its estimated energy contribution is around of 446.11 kcal/100 g. The concentration of essential amino acids in the extrudate meets the requirements established by FAO/WHO/UNU for children and adolescents. Protein digestibility increased and the content of available and resistant starch was reduced.ConclusionsThe optimal conditions of extrusion allowed to obtain an alternative snack with the essential amino acid requirements and higher protein digestibility.Significance and noveltyThe combination of two cereals allows to supplement the requirement of essential amino acids and greater protein digestibility.
Coalescence of Inner Water Droplets in Double Emulsions Due to Surfactant Transport through Oil
Authors: Leister Nico , Pfaff Daniel , Karbstein Heike Petra 
Published: December 2021

AbstractDouble emulsions of the water‐in‐oil‐in‐water type are promising encapsulation and delivery systems containing at least one hydrophilic and one lipophilic surfactant. Currently, there are still very few implementations on the market, as these systems are subject to extreme stability problems. This study focuses on stability problems induced by the transport of hydrophilic surfactant molecules through the lipophilic phase to the encapsulated inner water droplets. In particular, a model system was developed to quantify surfactant transport and resulting effects on the coalescence of encapsulated water droplets. Changes in stability of the inner water droplets are demonstrated for different surfactants and compared to the stability of the inner water‐in‐oil emulsions and corresponding double emulsions.
Improving the accuracy of random forest‐based land‐use classification using fused images and digital surface models produced via different interpolation methods
Authors: Akar Alper 
Published: December 2021

AbstractLand‐use maps produced with high accuracy are extremely important as a basis for better use of the land as they are widely utilized in many areas such as agricultural policies, natural resources management, and environmental operations. This study aimed to produce a high accuracy land‐use map using digital surface models (DSMs) produced using different interpolation methods and a random forest (RF) classifier. High spatial resolution Triplesat‐2 images, Worldview‐2 (WV‐2) images, and unmanned aerial vehicle (UAV) images were used in this study. First, DSMs were produced from the point cloud using different interpolation methods. The image fusion process was applied and these fused images were classified using an RF classifier together with the DSMs. Overall results showed that the DSM obtained by the kriging method yielded better results than the other methods by increasing the classification accuracy by 7%–13%. In addition, the McNemar test was applied to the images resulting from the classification of fused images with and without using DSMs to investigate the statistical significance of the differences. McNemar test demonstrated that the values were greater than 3.84, which revealed that the DSM produced via kriging interpolation had significantly increased the classification accuracy at a 95% confidence interval.
Comparing the dietary niche overlap and ecomorphological differences between invasive Hemidactylus mabouia geckos and a native gecko competitor
Authors: Lamb April D. , Lippi Catherine A. , Watkins‐Colwell Gregory J. , Jones Andrew , Warren Dan L. , Iglesias Teresa L. , Brandley Matthew C. , Dornburg Alex 
Published: December 2021

AbstractHemidactylus mabouia is one of the most successful, widespread invasive reptile species and has become ubiquitous across tropical urban settings in the Western Hemisphere. Its ability to thrive in close proximity to humans has been linked to the rapid disappearance of native geckos. However, aspects of Hemidactylus mabouia natural history and ecomorphology, often assumed to be linked with this effect on native populations, remain understudied or untested. Here, we combine data from ∂15N and ∂13C stable isotopes, stomach contents, and morphometric analyses of traits associated with feeding and locomotion to test alternate hypotheses of displacement between H. mabouia and a native gecko, Phyllodactylus martini, on the island of Curaçao. We demonstrate substantial overlap of invertebrate prey resources between the species, with H. mabouia stomachs containing larger arthropod prey as well as vertebrate prey. We additionally show that H. mabouia possesses several morphological advantages, including larger sizes in feeding‐associated traits and limb proportions that could offer a propulsive locomotor advantage on vertical surfaces. Together, these findings provide the first support for the hypotheses that invasive H. mabouia and native P. martini overlap in prey resources and that H. mabouia possess ecomorphological advantages over P. martini. This work provides critical context for follow‐up studies of H. mabouia and P. martini natural history and direct behavioral experiments that may ultimately illuminate the mechanisms underlying displacement on this island and act as a potential model for other systems with Hemidactylus mabouia invasions.
Sympatrically breeding congeneric seabirds (Stercorarius spp.) from Arctic Canada migrate to four oceans
Authors: Harrison Autumn‐Lynn , Woodard Paul F. , Mallory Mark L. , Rausch Jennie 
Published: December 2021

AbstractPolar systems of avian migration remain unpredictable. For seabirds nesting in the Nearctic, it is often difficult to predict which of the world's oceans birds will migrate to after breeding. Here, we report on three related seabird species that migrated across four oceans following sympatric breeding at a central Canadian high Arctic nesting location. Using telemetry, we tracked pomarine jaeger (Stercorarius pomarinus, n = 1) across the Arctic Ocean to the western Pacific Ocean; parasitic jaeger (S. parasiticus, n = 4) to the western Atlantic Ocean, and long‐tailed jaeger (S. longicaudus, n = 2) to the eastern Atlantic Ocean and western Indian Ocean. We also report on extensive nomadic movements over ocean during the postbreeding period (19,002 km) and over land and ocean during the prebreeding period (5578 km) by pomarine jaeger, an irruptive species whose full migrations and nomadic behavior have been a mystery. While the small sample sizes in our study limit the ability to make generalizable inferences, our results provide a key input to the knowledge of jaeger migrations. Understanding the routes and migratory divides of birds nesting in the Arctic region has implications for understanding both the glacial refugia of the past and the Anthropocene‐driven changes in the future.