bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of medication-related osteonecrosis of the jaw with bone SPECT/CT: relationship between patient characteristics and maximum standardized uptake value
Authors: Ogawa Ruri , Ogura Ichiro 
Published: May 2021

Objective: To analyze medication-related osteonecrosis of the jaw (MRONJ) with bone single photon emission computed tomography (SPECT)/CT, especially relationship between patient characteristics and maximum standardized uptake value (SUV). Methods: 48 patients with MRONJ who underwent bone SPECT/CT were prospectively included. MRONJ patients were included 34 osteoporosis and 14 bone metastases from 6 lung cancer, 6 breast cancer and 2 rectal cancer. The maximum SUV of the MRONJ patient characteristics were analyzed such as gender, location, underlying disease, medication and staging of MRONJ by Mann–Whitney U test. P-values lower than 0.05 indicate significant differences. Results: Regarding underlying disease, maximum SUV of patients with osteoporosis (18.69 ± 8.57) were significantly higher than those with bone metastases (12.28 ± 4.32, p = 0.005). Furthermore, maximum SUV of MRONJ was a significant difference for medication (denosumab: 13.62 ± 5.70 and minodronate: 22.98 ± 11.73, p = 0.009) and staging of MRONJ (Stage 2: 15.59 ± 8.06 and Stage 3: 21.51 ± 7.15, p = 0.014). Conclusion: Maximum SUV assessed by SPECT/CT was significantly increased in MRONJ patients with osteoporosis and Stage 3. Bone SPECT/CT could be an effective tool for the analysis of MRONJ.
Στάσεις και Αντιλήψεις εκπαιδευτικών ΕΠΑ.Λ. για την εξ αποστάσεως διδασκαλία όπως εφαρμόστηκε με την προσέγγιση "Μαθαίνουμε στο σπίτι"
Authors: Κορρές Δημήτριος , Σοφός Αλιβίζος (Λοΐζος) 
Published: May 2021

Σκοπός της έρευνας είναι η διερεύνηση των αντιλήψεων και των στάσεων που έχουν οι εκπαιδευτικοί των ΕΠΑΛ Κυκλάδων & Δωδεκανήσου για την εξ αποστάσεως εκπαίδευση και για τις επιπτώσεις του COVID-19 στην ακολουθητέα εκπαιδευτική διαδικασία. Ως ερευνητικό εργαλείο χρησιμοποιήθηκε το δομημένο ερωτηματολόγιο το οποίο συμπληρώθηκε ηλεκτρονικά από 126 εκπαιδευτικούς, όλων των ειδικοτήτων, οι οποίοι εργάζονται στα συγκεκριμένα ΕΠΑΛ. Τα αποτελέσματα της έρευνας καταδεικνύουν αφενός ότι οι εκπαιδευτικοί αναγνωρίζουν τα πλεονεκτήματα εφαρμογής της εξ αποστάσεως διδασκαλίας στην εκπαιδευτική διαδικασία και αφετέρου ότι εκφράζουν ορισμένες ανησυχίες για την αποτελεσματικότητα των συγκεκριμένων μεθόδων στην επίτευξη των μαθησιακών στόχων. Τα αποτελέσματα της έρευνας συμβάλλουν στην αναγνώριση των στάσεων, των αντιλήψεων και των προβληματισμών που έχουν οι εκπαιδευτικοί ως προς τη νέα εκπαιδευτική πραγματικότητα και δύναται να αξιοποιηθούν από τους φορείς άσκησης εκπαιδευτικών πολιτικών με σκοπό την αποτελεσματικότερη εφαρμογή των ΤΠΕ στην εποχή του COVID-19.
Μυστικοί πράκτορες εναντίον κορωνοϊού
Authors: Σαμούχος Πέτρος 
Published: May 2021

Το διαθεματικό project «Μυστικοί πράκτορες εναντίον κορωνοϊού» υλοποιήθηκε από τους μαθητές της Β΄ Δημοτικού του 6ου Δημοτικού Σχολείου Λιβαδειάς κατά τη διάρκεια της πανδημίας. Η παρούσα εργασία έχει ως στόχο να παρουσιάσει μια ολοκληρωμένη διδακτική πρόταση ασύγχρονης εξ αποστάσεως εκπαίδευσης και να αναδείξει τα οφέλη που προκύπτουν από την κινητοποίηση του μαθησιακού ενδιαφέροντος και της αυτενέργειας των μαθητών. Οι μαθητές μέσω πρωτότυπων και παιγνιωδών δραστηριοτήτων έκαναν παρατηρήσεις για τα μικρόβια, υιοθέτησαν κανόνες ατομικής υγιεινής, έκαναν επανάληψη στα διδακτικά αντικείμενα της τάξης, ασχολήθηκαν με τη ρομποτική και ανέπτυξαν τη δημιουργικότητά τους. Το project επεδίωξε και πέτυχε την ενεργή συμμετοχή των γονέων των μαθητών σε όλες τις εκφάνσεις του. Με την υλοποίησή του ενεργοποιήθηκε το ενδιαφέρον των μαθητών για τη μαθησιακή διαδικασία και ανέπτυξαν μεταγνωστικές δεξιότητες υιοθετώντας και εφαρμόζοντας στην πράξη κανόνες ατομικής υγιεινής. Τέλος με την ολοκλήρωσή του πραγματοποιήθηκε εσωτερική αξιολόγηση τόσο από τους μαθητές όσο και από τον εκπαιδευτικό.
Η Εποχή Του Covid-19 και η Εξ Αποστάσεως Διδασκαλία στην Προσχολική Αγωγή
Authors: Μπούρα Στυλιανή 
Published: May 2021

Η εργασία μέσω των βιβλιογραφικών αναφορών και της έρευνας αποτελεί μια μελέτη περίπτωσης Νηπιαγωγείου στην περιοχή της Θεσσαλίας που απαριθμεί πάνω από 100 μαθητές. Αναδεικνύει την επιθυμία αλλά και τη δυνατότητα εφαρμογής τόσο της σύγχρονης όσο και της ασύγχρονης διδασκαλίας στην προσχολική ηλικία. Λόγω του ιδιαίτερου της ηλικίας αυτής θα φανεί κατά πόσο η εξ αποστάσεως διδασκαλία συνιστά το πλέον πρόσφορο εργαλείο για να διατηρήσουν οι μαθητές και οι εκπαιδευτικοί την επαφή τους με την εκπαιδευτική διαδικασία σε έκτακτες συνθήκες όπως αυτές που βιώνει η χώρα μας (Covid-19). Παρουσιάζεται το κατά πόσο ο/η Διευθυντής/ντρια σχολικής μονάδας μπορεί να εμπνεύσει, να καθοδηγήσει αλλά και να οργανώσει τους εκπαιδευτικούς για την εφαρμογή της εξ αποστάσεως διδασκαλίας όταν το τεχνολογικό επίπεδο γνώσεων των εκπαιδευτικών παρουσιάζει μεγάλες διακυμάνσεις. Σκοπός της έρευνας είναι να αναδείξει όχι μόνο την επιθυμία των γονέων αλλά και τη δυνατότητα υλοποίησης από πλευράς τους της εξ αποστάσεως διδασκαλίας
Ηλεκτρονικός Ατομικός Φάκελος Καριέρας Μαθητών και Σχολικός Επαγγελματικός Προσανατολισμός
Authors: Αντωνίου Θεόδωρος , Βασίλογλου Γεώργιος , Βασίλογλου Χαράλαμπος , Καραϊσαρλή Μαρία , Βλαχοδήμου Ευπραξία 
Published: May 2021

Στο σύγχρονο περιβάλλον της ρευστότητας και αβεβαιότητας οι μαθητές καλούνται να πάρουν αποφάσεις για την επαγγελματική τους πορεία και εξέλιξη καθώς και αποφάσεις ζωής που συνδέονται άμεσα με τον τρόπο οργάνωσης της ενήλικης ζωής τους. Ο Επαγγελματικός Προσανατολισμός κάνοντας μεγάλα άλματα προωθώντας νέες θεωρίες διεξάγοντας σχετικές έρευνες και πρακτικές που στοχεύουν στο συνυπολογισμό όλων πτυχών της καριέρας για μια βιώσιμη απασχόληση για όλους τους ανθρώπους. Ο Σχολικός Επαγγελματικός Προσανατολισμός, Σ.Ε.Π. ενισχύει την προσωπική τους προσπάθεια να κατανοήσουν και να αναπτύξουν τον εαυτό τους. Στο πλαίσιο αυτό έχει αναπτυχθεί και συνεχώς αναπτύσσεται η καριέρα μέσω χαρτοφυλακίου (ατομικού φακέλου) portfolio και ειδικότερα του ηλεκτρονικού χαρτοφυλακίου (e-portfolio). Το e-portfolio μπορεί να παρέχει συνεχώς την ευκαιρία στο άτομο να αναδεικνύει τις ικανότητές του να συλλέγει, να οργανώνει, να ερμηνεύει και να ασκεί κριτική πάνω σε ατομικά του έγγραφα και πηγές πληροφοριών. Μπορεί να συμβάλλει στη συνεχή επαγγελματική εξέλιξη του ατόμου, στην επιλογή επαγγέλματος, αλλά και στον επαναπροσανατολισμό της καριέρας του.
A long way to go: engagement of men and boys in country family planning commitments and implementation plans
Authors: Hook Christopher , Hardee Karen , Shand Tim , Jordan Sandra , Greene Margaret E. 
Published: May 2021

Background: Evidence shows that, to reach global goals related to women and girls’ access to modern family planning (FP) and gender equality, it is critical to understand and account for the role of men and boys as users of reproductive health services, as partners for millions of women & girls around the world, and as advocates in their communities. Under the Family Planning 2020 (FP2020) partnership, countries were encouraged to develop costed implementation plans and action plans in an effort to provide 120 million additional women and girls with contraception. As FP2020 becomes FP2030, reviewing these previously-developed strategies helps understand the extent to which countries considered the engagement of men as an important aspect of their family planning portfolios. Methods: We conducted textual analysis on commitments and implementation plans related to achieving FP2020 commitments in seven countries in Africa and one in Asia to determine the extent to which male engagement was incorporated into country or subnational family planning goals, with particular focus on FP policy, program, and financial commitments. Results: Some of the documents analyzed included robust plans for including male engagement in their efforts to expand access to FP. The strongest aspects of male engagement programming were those that sought to engage men as advocates for women’s access to and use of FP services, and improve men’s knowledge and attitudes related to contraception and reproduction. The weakest aspects were engaging men as users of services and, vitally, tackling underlying gender norms which hamper men’s and women’s health-seeking behaviors and attitudes. Conclusions: Developing FP programs that target men and boys as people deserving of reproductive health services, as partners with women in building their families, and as social activists in their communities, will complement and strengthen existing FP programs as well as promote broader goals related to gender equality.
The abTEM code: transmission electron microscopy from first principles
Authors: Madsen Jacob , Susi Toma 
Published: May 2021

Simulation of transmission electron microscopy (TEM) images or diffraction patterns is often required to interpret experimental data. Since nuclear cores dominate electron scattering, the scattering potential is typically described using the independent atom model, which completely neglects valence bonding and its effect on the transmitting electrons. As instrumentation has advanced, new measurements have revealed subtle details of the scattering potential that were previously not accessible to experiment. We have created an open-source simulation code designed to meet these demands by integrating the ability to calculate the potential via density functional theory (DFT) with a flexible modular software design. abTEM can simulate most standard imaging modes and incorporates the latest algorithmic developments. The development of new techniques requires a program that is accessible to domain experts without extensive programming experience. abTEM is written purely in Python and designed for easy modification and extension. The effective use of modern open-source libraries makes the performance of abTEM highly competitive with existing optimized codes on both CPUs and GPUs and allows us to leverage an extensive ecosystem of libraries, such as the Atomic Simulation Environment and the DFT code GPAW. abTEM is designed to work in an interactive Python notebook, creating a seamless and reproducible workflow from defining an atomic structure, calculating molecular dynamics (MD) and electrostatic potentials, to the analysis of results, all in a single, easy-to-read document. This article provides ongoing documentation of abTEM development. In this first version, we show use cases for hexagonal boron nitride, where valence bonding can be detected, a 4D-STEM simulation of molybdenum disulfide including ptychographic phase reconstruction, a comparison of MD and frozen phonon modeling for convergent-beam electron diffraction of a 2.6-million-atom silicon system, and a performance comparison of our fast implementation of the PRISM algorithm for a decahedral 20000-atom gold nanoparticle.
CORPO E POLÍTICA: UMA LEITURA SOBRE ELISABETH DA BOÊMIA
Authors: Lacerda Tessa Moura 
Published: May 2021

Sou um corpo em meio a outros corpos. Descartes afirma isso na Sexta Meditação quando inicia a análise da sensação, visando demonstrar a existência dos corpos. O que são os outros corpos do ponto de vista de um sujeito de conhecimento? Aparentemente, o filósofo jamais pôde contemplar o aspecto político dessa consideração – sou um corpo em meio a outros corpos. A Sexta Meditação demonstra a distinção radical entre alma e corpo e a união de fato entre alma e corpo no ser humano. Elisabeth da Boêmia, interlocutora de Descartes, é a primeira a apontar a contradição na letra da Sexta Meditação, do ponto de vista da interação entre alma e corpo. Elisabeth sugere que é mais fácil conceber a alma como material do que supor a influência real entre duas substâncias radicalmente distintas. Elisabeth teria uma concepção material da alma? O que o diálogo epistolar entre Elisabeth e Descartes mostra é a presença do corpo nas reflexões de Elisabeth, presença do corpo físico e do corpo político. Talvez Elisabeth entenda melhor do que Descartes o que é ser um corpo em meio a outros corpos.
O HOMEM CO-CRIADOR DO MUNDO PELA IMAGEM DE SI MESMO UM ESTUDO DE SARTRE E NIETZSCHE
Authors: Pimentel Ferreira  Vinícius 
Published: May 2021

A partir da leitura das obras O ser e o Nada de Sartre, bem como o livro O Nascimento da Tragédia, de Nietzsche, pretendo mostrar de que modo os dois autores identificam o homem enquanto sujeito sem uma identidade metafísica, na posição de criadores de si mesmos e do mundo, perpassando por discussões como liberdade, responsabilidade e possibilidade.
PEIXES DO CRETÁCEO DA ILHA DE ITAPARICA (BACIA DO RECÔNCAVO), BAHIA, BRASIL
Authors: Calixto Bianca de Moura 
Published: May 2021

A Bacia Sedimentar do Recôncavo é uma área de grande significância à paleontologia (Magnavita et al., 2005; Silva et al., 2012). Uma breve comparação da paleoictiofauna encontrada na Ilha de Itaparica com outros depósitos cretácicos brasileiros revela a necessidade em investir mais esforçosna busca por conhecimento sobre os fósseis desta região. O objetivo geral do plano de trabalho foi descrever e identificar espécimes de peixes de idade cretácica coletados na Ilha de Itaparica, Bahia e tombados na Coleção de Paleontologia do Museu de Zoologia da UEFS.
COMUNICAÇÃO ENTRE INSTÂNCIAS DE NÉVOA EM AMBIENTE DE EMULAÇÃO MININET
Authors: Santos Lima Emerson 
Published: May 2021

Atualmente as pessoas vivem conectadas a dispositivos como smartphones, smartwatches, e smart TVs. Além disto, casas são monitoradas por uma série de dispositivos como câmeras, sensores de presença (utilizado comumente em alarmes), sensores de temperatura, entre outros.
Investigação de materiais curriculares educativos para as Relações Étnico-Raciais
Authors: Evangelista do Rosário de Jesus Natali 
Published: May 2021

O ano de 2018 é marcado pelos quinze anos da Lei 10.639/2003 e há dez anostemos investido em pesquisas e acumulado conhecimento que tem a lei e o temarelações étnico-raciais na centralidade, conforme os trabalhos de Barzano (2008);Sampaio (2013); Santos (2014); Dias et all (2014) e alguns outros que estão emandamento nas monografias de trabalho de conclusão de curso (TCC) do curso deLicenciatura em Ciências Biológicas, Pedagogia e tese no Programa de Pós-Graduação em Ensino, Filosofia e História das Ciências.
Repeatability and agreement of biometric measurements using spectral domain anterior segment optical coherence tomography and Scheimpflug tomography in keratoconus
Authors: Li Ye , Gokul Akilesh , McGhee Charles , Ziaei Mohammed 
Published: May 2021

Purpose
To compare the repeatability and agreement in biometric measurements using Spectral Domain Anterior Segment OCT (AS-OCT, REVO-NX, Optopol) and Scheimpflug tomography (Pentacam-AXL, Oculus) in keratoconus.

Methods
Prospective case series at a university hospital tertiary center. Axial length (AL), anterior chamber depth (ACD), central corneal thickness (CCT), and thinnest corneal thickness (TCT) were measured using both devices in patients with keratoconus. Three groups were analyzed: eyes with no prior crosslinking or contact lens wear (Group A), eyes with prior crosslinking (Group B), and eyes with prior contact lens wear (Group C). Repeatability and agreement of measurements were analyzed.

Results
The study comprised of 214 eyes of 157 subjects. In Group A (n = 95 eyes), Group B (n = 86 eyes), and Group C (n = 33 eyes), intraclass correlation coefficient (ICC) was higher than 0.90 for all examined parameters, except for ACD readings in Group A with the REVO-NX (ICC = 0.83). Differences in ACD, TCT, and CCT were significantly different between the two devices for Groups A, B and C (p<0.05). AL measurements differed significantly in Groups A and B (p<0.05) but not in Group C (p = 0.18). Repeatability did not vary significantly between Groups A, B, or C in any parameter with both devices (p>0.05). There was poor agreement between the two devices across all parameters (p<0.05).

Conclusions
Both devices demonstrated good repeatability but poor agreement across AL, ACD, CCT and TCT measurements. There was no significant difference in repeatability in virgin eyes compared to eyes with prior crosslinking or contact lens wear, however, the interchangeable use of the two devices is not recommended.
Career orientations of medical students: A Q-methodology study
Authors: Gennissen Lokke , Stegers-Jager Karen , van Exel Job , Fluit Lia , de Graaf Jacqueline , de Hoog Matthijs 
Published: May 2021

IntroductionIn pursuing optimal health care, an adequate medical workforce is crucial. However, many countries are struggling with a misalignment of students’ specialty preferences and societal needs regarding the future medical workforce. In order to bridge this gap, it is relevant to gain a better understanding of the medical career choice processes. We explored career orientations among medical students in the Netherlands and their implications for future career choices.MethodsWe used Q-methodology, a hybrid qualitative–quantitative method, to explore career orientations of medical students. Medical students from two universities in the Netherlands, varying in year of progression of medical school, ranked 62 statements with regard to importance for their future career choice. Participants explained their ranking in an interview and completed a questionnaire regarding demographics. Using by-person factor analysis we identified groups of individuals with similar orientations.ResultsTwenty-four students participated in this study, resulting in three distinct orientations towards future careers: a first career orientation that highly values lifelong self-development; a second that values work-life balance, and a third that was more concerned with achievement and recognition of their work.ConclusionMedical students’ career orientations differed in the importance of challenge, work-life balance, and need for recognition. This knowledge can help to design interventions to shift career choices of medical students closer towards future needs in society. Offering career coaching to students that challenges them to explore and prioritise their values, needs and motivations, for example using the materials form this study as a tool, and stimulates them to consider specialties accordingly, could be a promising strategy for guiding students to more long-term satisfying careers.
Real-life clinical sensitivity of SARS-CoV-2 RT-PCR test in symptomatic patients
Authors: Kortela Elisa , Kirjavainen Vesa , Ahava Maarit J. , Jokiranta Suvi T. , But Anna , Lindahl Anna , Jääskeläinen Anu E. , Jääskeläinen Annemarjut J. , Järvinen Asko , Jokela Pia , Kallio-Kokko Hannimari , Loginov Raisa , Mannonen Laura , Ruotsalainen Eeva , Sironen Tarja , Vapalahti Olli , Lappalainen Maija , Kreivi Hanna-Riikka , Jarva Hanna , Kurkela Satu , Kekäläinen Eliisa 
Published: May 2021

Background
Understanding the false negative rates of SARS-CoV-2 RT-PCR testing is pivotal for the management of the COVID-19 pandemic and it has implications for patient management. Our aim was to determine the real-life clinical sensitivity of SARS-CoV-2 RT-PCR.

Methods
This population-based retrospective study was conducted in March–April 2020 in the Helsinki Capital Region, Finland. Adults who were clinically suspected of SARS-CoV-2 infection and underwent SARS-CoV-2 RT-PCR testing, with sufficient data in their medical records for grading of clinical suspicion were eligible. In addition to examining the first RT-PCR test of repeat-tested individuals, we also used high clinical suspicion for COVID-19 as the reference standard for calculating the sensitivity of SARS-CoV-2 RT-PCR.

Results
All 1,194 inpatients (mean [SD] age, 63.2 [18.3] years; 45.2% women) admitted to COVID-19 cohort wards during the study period were included. The outpatient cohort of 1,814 individuals (mean [SD] age, 45.4 [17.2] years; 69.1% women) was sampled from epidemiological line lists by systematic quasi-random sampling. The sensitivity (95% CI) for laboratory confirmed cases (repeat-tested patients) was 85.7% (81.5–89.1%) inpatients; 95.5% (92.2–97.5%) outpatients, 89.9% (88.2–92.1%) all. When also patients that were graded as high suspicion but never tested positive were included in the denominator, the sensitivity (95% CI) was: 67.5% (62.9–71.9%) inpatients; 34.9% (31.4–38.5%) outpatients; 47.3% (44.4–50.3%) all.

Conclusions
The clinical sensitivity of SARS-CoV-2 RT-PCR testing was only moderate at best. The relatively high false negative rates of SARS-CoV-2 RT-PCR testing need to be accounted for in clinical decision making, epidemiological interpretations, and when using RT-PCR as a reference for other tests.
Modelling the cost effectiveness of non-alcoholic fatty liver disease risk stratification strategies in the community setting
Authors: Congly Stephen E. , Shaheen Abdel Aziz , Swain Mark G. 
Published: May 2021

Background
Non-alcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. Identifying high-risk patients is critical to best utilize limited health care resources. We established a community-based care pathway using 2D ultrasound shear wave elastography (SWE) to identify high risk patients with NAFLD. Our objective was to assess the cost-effectiveness of various non-invasive strategies to correctly identify high-risk patients.

Methods
A decision-analytic model was created using a payer’s perspective for a hypothetical patient with NAFLD. FIB-4 [≥1.3], NAFLD fibrosis score (NFS) [≥-1.455], SWE [≥8 kPa], transient elastography (TE) [≥8 kPa], and sequential strategies with FIB-4 or NFS followed by either SWE or TE were compared to identify patients with either significant (≥F2) or advanced fibrosis (≥F3). Model inputs were obtained from local data and published literature. The cost/correct diagnosis of advanced NAFLD was obtained and univariate sensitivity analysis was performed.

Results
For ≥F2 fibrosis, FIB-4/SWE cost $148.75/correct diagnosis while SWE cost $276.42/correct diagnosis, identifying 84% of patients correctly. For ≥F3 fibrosis, using FIB-4/SWE correctly identified 92% of diagnoses and dominated all other strategies. The ranking of strategies was unchanged when stratified by normal or abnormal ALT. For ≥F3 fibrosis, the cost/correct diagnosis was less in the normal ALT group.

Conclusions
SWE based strategies were the most cost effective for diagnosing ≥F2 fibrosis. For ≥F3 fibrosis, FIB-4 followed by SWE was the most effective and least costly strategy. Further evaluation of the timing of repeating non-invasive strategies are required to enhance the cost-effective management of NAFLD.