bluuebunny/crossref_metadata_2025_split huggingface dataset:
Core parametric study for enhancing the radioisotope production in the IEA-R1 research reactor
Authors: Stefani Giovanni Laranjo , Genezini Frederico Antônio , Santos Thiago Augusto , Moreira João Manoel de Losada 
Published: October 2021

In this work a parametric study was carried to increase the production of radioisotopes in the IEA-R1 research reactor. The changes proposed to implement in the IEA-R1 reactor core were the substitution of graphite reflectors by beryllium reflectors, the removal of 4 fuel elements to reduce the core size and make available 4 additional locations to be occupied by radioisotope irradiation devices. The key variable analyzed is the thermal neutron flux in the irradiation devices. The proposed configuration with 20 fuel elements in an approximately cylindrical geometry provided higher average neutron flux (average increment of 12.9 %) allowing higher radioisotope production capability. In addition, it provided 4 more positions to install irradiation devices which allow a larger number of simultaneous irradiations practically doubling the capacity of radioisotope production in the IEA-R1 reactor. The insertion of Be reflector elements in the core has to be studied carefully since it tends to promote strong neutron flux redistribution in the core. A verification of design and safety parameters of the proposed core was carried out. The annual fuel consumption will increase about 17 % and more storage space for spent fuel will be required.
A fejlődés-pszichofiziológia 30 éve Magyarországon (1990–2020)
Authors: Csépe Valéria 
Published: October 2021

A magyarországi fejlődés-pszichofiziológia három évtizedes történetét összefoglaló tanulmány a jelentősebb kutatások eredményeit négy főbb témacsoportban mutatja be. Ezek: a) a fejlődés-pszichofiziológiai módszerekkel végzett kutatások kezdetei, b) a nemzetközi kutatási kapcsolatok főbb területei, c) az eseményhez kötött agyi potenciálok módszerével végzett kutatások hazai főbb eredményei, valamint azok nemzetközi beágyazottsága és trendjei, d) a kognitív fejlődés-idegtudomány önálló területének kialakulása. Az áttekintésben hangsúlyosan jelenik meg a kutatási terület szerves kapcsolódása a pszichológia releváns ágaihoz (fejlődés-, kísérleti, kognitív pszichológia) és vizsgált életkori szakaszaihoz, beleértve a humán fejlődés fiziológiai módszereket alkalmazó pszichológiai kutatásának teljes vertikumát a tipikustól az atipikusig, a csecsemőkortól az öregedésig.
The review summarizes the three-decades history of developmental psychophysiology in Hungary and presents the significant scientific achievements in four thematic domains. These are: a) the first years of research using developmental psychophysiological methods, b) the main areas of international research relations, c) the main results of research using event-related brain potentials, and their international relations and trends, d) the rise of a new independent field called cognitive developmental neuroscience. The review highlights the important links between the research area and the relevant branches of psychology (developmental, experimental, cognitive psychology) as well as the age range studied, including the entire continuum of psychological research on human development using physiological methods, from typical to atypical, and from infancy to aging.
Post-covid condition in adults and children
Authors: Baimukhambetova Dina V. , Gorina Anastasia O. , Rumyantsev Mikhail A. , Shikhaleva Anastasia A. , El-Taravi Yasmin A. , Bondarenko Elena D. , Kapustina Valentina A. , Munblit Daniil B. 
Published: October 2021

Despite the impressive progress in diagnosis and management of acute COVID-19, data regarding the consequences of this infection are just emerging. The World Health Organization has proposed the term post-COVID condition (PCC) to describe the wide range of sequelae of acute COVID-19. With more than 200 million confirmed cases of COVID-19, PCC may develop into a major problem for many years to come for the millions of COVID-19 survivors worldwide. Few studies were conducted in primary care, and very few studies have focused exclusively on children and adolescents.Objective. To review existing data on PCC. Analysis of manuscripts published in peer-reviewed journals and clinical protocols. PCC is characterized by a wide range of systemic, cardio-pulmonary, gastrointestinal, neurological, and psychosocial symptoms.Conclusion. Although PCC prevalence is difficult to estimate due to methodological limitations of the existing studies, there is no doubt that this problem is a significant healthcare burden. There is a need for further observational and interventional studies to establish optimal PCC prevention and management strategies.
Development of fibrosis and impairment of lung function in patients with a new coronavirus disease
Authors: Leshchenko Igor´ V. , Glushkova Tatyana V. 
Published: October 2021

The aim: review scientific research to find out whether the new coronavirus infection (NCI) causes fibrotic changes in the lungs and, if any, how long they persist and whether functional disorders of the respiratory system accompany them. Disruption of the functional state of the lungs in patients with severe novel coronavirus disease (COVID-19) is still seen 6 months after completion of inpatient treatment. High-resolution computed tomography (HRCT) demonstrates persistent pathological changes in the lungs, some of which are fibrosis-like. Pathomorphological features of the COVID-19 course, as well as the ability of the virus to activate connective tissue growth factor (CTGF) and enhance the signaling of transforming growth factor-beta (TGF-β), can contribute to lung tissue fibrosis. Increased titers of antinuclear autoantibodies and specific autoantibodies indirectly reveal dysregulation of the immune response leading to the progression of organizing pneumonia and fibrotic changes in the lung tissue. These increased titers can also indicate the need to prescribe immunosuppressive and antifibrotic drugs. Researchers are considering the possibility of including antifibrotic drugs in combination therapy for severe COVID-19 in the early stages of treatment in patients with risk factors for developing pulmonary fibrosis. However, further monitoring and determination of the role of antifibrotic drugs are required. Sometimes patients with COVID-19 develop severe, irreversible fibrotic lung disease, and lung transplantation is the only treatment option.Conclusion. There is no unequivocal opinion among researchers concerning the clinical significance and further prognosis of COVID-19 so far, which is a reason for further studies.
Asthma and COVID-19: Аn overview of the guidelines for the management of asthma patients during the COVID-19 pandemic
Authors: Osipova Veronika V. , Osipova Galina L. , Zaryanova Elena A. , Terekhov Dmitry V. 
Published: October 2021

The emergence of a new disease COVID-19 (coronavirus disease 2019), caused by the coronavirus named SARS-CoV-2, has significantly changed the usual interaction pattern between a doctor and a patient. Previous large studies have identified risk factors for a severe course of COVID-19, including old age, hypertension, diabetes, cardiovascular diseases, and chronic obstructive pulmonary disease. However, asthma and respiratory allergy have not been identified as risk factors for the severe disease. These factors give clues to the pathogenesis of COVID-19, approaches to the controller medications, target therapy, allergen-specific immunotherapy (ASIT) in patients with various phenotypes and endotypes of asthma during the pandemic.The purposeof this review is to summarize the currently available knowledge about SARS-CoV-2, T2-endotype of asthma, eosinophilic inflammation. The article provides an overview of the data from studies of COVID-19 patients with asthma, the main recommendations of the Global Initiative for Asthma (2021) and the Ministry of Health of the Russian Federation. It shows that targeting the endotypes and phenotypes of asthma can influence the management of COVID-19 patients with asthma. The influence of the imbalance of the immune system, pro-inflammatory cytokines, and effector cells in patients with asthma on the development and progression of COVID-19 is considered. Recommendations are given for the controller medications, targeted therapy, allergen-specific immunotherapy during the pandemic.Conclusion.The current recommendations for asthma treatment, based on the latest research of COVID-19, deepen our understanding of the course of COVID-19 in patients with different phenotypes and endotypes of asthma, approaches to traditional methods of treating asthma according to clinical guidelines during the pandemic.
Invasive aspergillosis associated with COVID-19
Authors: Ovsyannikov Nikolay V. , Bilevich Olga A. , Zenkova Lyudmila A. , Vasilieva Olga V. 
Published: October 2021

The novel coronavirus (COVID-19) pandemic announced by the World Health Organization in March 2020 has brought new tasks to the medical community that require immediate solutions. Recent studies have shown that invasive aspergillosis associated with coronavirus infection caused by COVID-19 often aggravates the course of the disease and leads to death. The article presents a clinical case of acute invasive aspergillosis in a COVID-19 patient with chronic somatic pathology but no risk factors for developing invasive pulmonary aspergillosis. The disease was progressing rapidly and led to a fatal outcome.Conclusion. In the case presented, invasive pulmonary aspergillosis was diagnosed with the help of histological examination of autopsy material.
Comparison of seasonal pattern in patients with warfarin overdose
Authors: Bodagh Haleh , Separham Ahmad , Parizad Razieh , Vahedi Leila , Ghodrati Peyman , Bager Bodagh Mohamad , Amiri Bita 
Published: October 2021

Objectives: The most common anticoagulant drug in the world is warfarin. Overdoses of warfarin may follow seasonal patterns, but the information is scarce. This study investigated possible seasonal variations in warfarin overdose among various age groups living in cold climates.
Results: Seasonal patterns were observed in warfarin overdoses. Warfarin overdoses were more common among the patients under 65 years old during winter (P-value = 0.03), whereas almost identical findings were found among the patients 65 and older, although numerically more cases were seen during the summer season (P-value = 0.8).
Conclusions: The results of the current study showed that warfarin overdoses in the patients younger than 65 years showed a seasonal pattern peaking in the winter months. However, these findings did not have any relation with older patients. To confirm the results of the present study, larger prospective multicenter studies in a variety of climate settings are needed.
MEDIAÇÃO PEDAGÓGICA A PARTIR DA PERCEPÇÃO DE TUTORES DE EDUCAÇÃO A DISTÂNCIA DA UNIVERSIDADE FEDERAL DO AMAPÁ
Authors: Andrade Elisângela Lima de 
Published: October 2021

Este artigo apresenta uma análise da percepção de tutores de EaD de uma Universidade pública do norte do país acerca da mediação pedagógica e, ainda, da prática tutorial. O programa de EaD da instituição foi escolhido por ser vinculado à Universidade Aberta do Brasil (UAB). O embasamento teórico se deu com autores respeitados no meio científico nas áreas da Educação e Educação a Distância, como Mill, Moore e Kearsley, Garcia Aretio, entre outros. A metodologia utilizada foi a pesquisa qualitativa, com estratégia metodológica de estudo de caso. As técnicas de coleta de dados utilizadas foram um questionário, aplicado a 24 tutores, que serviu para definir os critérios de exclusão/inclusão dos participantes e entrevistas semiestruturadas. Foi realizada também uma visita num polo de EaD da instituição investigada, com a finalidade de se conhecer o lócus de pesquisa do tutor presencial. Procedemos depois à análise dos dados usando a técnica de análise de conteúdo de Bardin (2011). Os resultados concluem que os tutores avaliam a sua prática tutorial e a mediação pedagógica como positivas, mas reconhecem que precisam de uma melhor formação continuada em Educação a Distância e de uma maior interação com a equipe polidocente, em especial com os professores formadores. A pesquisa também conclui que é necessário maior investimento no tutor, que é peça fundamental na construção do conhecimento do aprendente na Educação a Distância.

Palavras-chave: Educação a Distância. Tutor. Mediação Pedagógica. Interação. Formação Inicial e Continuada.
PRODUÇÃO DE NARRATIVAS DIGITAIS EM CONTEXTOS DE MULTILETRAMENTOS
Authors: Ferreira Lopes Maria Ailma 
Published: October 2021

Este artigo objetiva discutir a produção de narrativas digitais em contextos de multiletramentos. Dessa forma, inicialmente, se fez uma breve descrição de alguns conceitos acerca dos novos letramentos, mídia, multimídia, hipermídia e narrativas digitais. Em seguida, explicitou-se sobre as narrativas digitais integradas com as Tecnologias Digitais da Informação e Comunicação - TDIC e, por fim, apresentou-se o recurso digital Pixton integrado aos multiletramentos no processo de elaboração de narrativas. A metodologia utilizada foi de caráter bibliográfico. Os aportes teóricos basearam-se em: Rojo (2012; 2013); Santos (2018); Krening et al. (2017); Almeida e Valente (2012); Gava (2015) e outros autores. A pergunta norteadora do estudo assinala-se: como produzir narrativas digitais em contextos de multiletramentos? Para direcionamento do estudo tem-se como objetivo geral: discutir a produção de narrativas digitais em contextos de multiletramentos. Como resultado do estudo discutimos que as narrativas digitais podem ser produzidas por meio do recurso digital de criação de Histórias em Quadrinhos - HQ on-line denominado Pixton. Nele elabora-se HQ em contextos de multiletramentos porque envolve os modos linguísticos do oral e do escrito, o visual por conter as imagens, o leiaute de página e o formato de tela. Contempla também os aspectos multimodais que é a interconexão entre todos os elementos citados. Os aspectos mencionados permitem a leitura e escrita no espaço digital criando-se narrativas digitais em Histórias em Quadrinhos - HQ.

Palavras-chave: Narrativas digitais. Multiletramentos. Letramentos. Tecnologias.
Training in Making Learning Media in The Form of Attractive Photos for Teachers to Increase Student Learning Motivation At SMPN 7 Banjarmasin
Authors: Abbas Ersis Warmansyah , Rusmaniah Rusmaniah , Rival Muhammad , Yusup Yusup , Maulana Muhammad 
Published: October 2021

Pandemi Covid-19 secara tiba-tiba mengharuskan elemen pendidikan untuk mempertahankan pembelajaran secara online. Demi optimalnya kegiatan pembelajaran tersebut, sudah seharusnya didukung dengan penggunaan media pembelajaran yang dapat meningkatkan motivasi belajar siswa, Satu diantaranya adalah melalui tampilan foto yang menarik sebagai media pembelajaran. Guru dapat mengedit foto melalui aplikasi smartphone. Tujuan dari artikel ini menjelaskan bagaimana dampak dari pelatihan membuat media pembelajaran berupa foto menarik untuk guru SMPN 7 Banjarmain. Dalam mempertajam hasil yang diperoleh dari pengabdian masyarakat, penulis menggunakan studi literature yang relevan. Hasil dari artikel ini mendeskripsikan bahwa pelatihan yang dilakukan dapat memberikan soft skill kepada guru-guru dalam mengedit foto menarik sebagai media pembelajaran yang menarik dengan memanfaatkan aplikasi smartphone.
Brief Electrical Stimulation Accelerates Axon Regeneration and Promotes Recovery Following Nerve Transection and Repair in Mice
Authors: Sayanagi Junichi , Acevedo-Cintrón Jesús A. , Pan Deng , Schellhardt Lauren , Hunter Daniel A. , Snyder-Warwick Alison K. , Mackinnon Susan E. , Wood Matthew D. 
Published: October 2021

Background:Clinical outcomes following nerve injury repair can be inadequate. Pulsed-current electrical stimulation (ES) is a therapeutic method that facilitates functional recovery by accelerating axon regeneration. However, current clinical ES protocols involve the application of ES for 60 minutes during surgery, which can increase operative complexity and time. Shorter ES protocols could be a strategy to facilitate broader clinical adoption. The purpose of the present study was to determine if a 10-minute ES protocol could improve outcomes.Methods:C57BL/6J mice were randomized to 3 groups: no ES, 10 minutes of ES, and 60 minutes of ES. In all groups, the sciatic nerve was transected and repaired, and, in the latter 2 groups, ES was applied after repair. Postoperatively, changes to gene expression from dorsal root ganglia were measured after 24 hours. The number of motoneurons regenerating axons was determined by retrograde labeling at 7 days. Histomorphological analyses of the nerve were performed at 14 days. Function was evaluated serially with use of behavioral tests up to 56 days postoperatively, and relative muscle weight was evaluated.Results:Compared with the no-ES group, both ES groups demonstrated increased regeneration-associated gene expression within dorsal root ganglia. The 10-minute and 60-minute ES groups demonstrated accelerated axon regeneration compared with the no-ES group based on increased numbers of labeled motoneurons regenerating axons (mean difference, 202.0 [95% confidence interval (CI), 17.5 to 386.5] and 219.4 [95% CI, 34.9 to 403.9], respectively) and myelinated axon counts (mean difference, 559.3 [95% CI, 241.1 to 877.5] and 339.4 [95% CI, 21.2 to 657.6], respectively). The 10-minute and 60-minute ES groups had improved behavioral recovery, including on grid-walking analysis, compared with the no-ES group (mean difference, 11.9% [95% CI, 3.8% to 20.0%] and 10.9% [95% CI, 2.9% to 19.0%], respectively). There was no difference between the ES groups in measured outcomes.Conclusions:A 10-minute ES protocol accelerated axon regeneration and facilitated functional recovery.Clinical Relevance:The brief (10-minute) ES protocol provided similar benefits to the 60-minute protocol in an acute sciatic nerve transection/repair mice model and merits further studies.
Predicting Anterior Cruciate Ligament Reconstruction Revision
Authors: Martin R. Kyle , Wastvedt Solvejg , Pareek Ayoosh , Persson Andreas , Visnes Håvard , Fenstad Anne Marie , Moatshe Gilbert , Wolfson Julian , Engebretsen Lars 
Published: October 2021

Background:Several factors are associated with an increased risk of anterior cruciate ligament (ACL) reconstruction revision. However, the ability to accurately translate these factors into a quantifiable risk of revision at a patient-specific level has remained elusive. We sought to determine if machine learning analysis of the Norwegian Knee Ligament Register (NKLR) can identify the most important risk factors associated with subsequent revision of primary ACL reconstruction and develop a clinically meaningful calculator for predicting revision of primary ACL reconstruction.Methods:Machine learning analysis was performed on the NKLR data set. The primary outcome was the probability of revision ACL reconstruction within 1, 2, and/or 5 years. Data were split randomly into training sets (75%) and test sets (25%). Four machine learning models were tested: Cox Lasso, survival random forest, generalized additive model, and gradient boosted regression. Concordance and calibration were calculated for all 4 models.Results:The data set included 24,935 patients, and 4.9% underwent a revision surgical procedure during a mean follow-up (and standard deviation) of 8.1 ± 4.1 years. All 4 models were well-calibrated, with moderate concordance (0.67 to 0.69). The Cox Lasso model required only 5 variables for outcome prediction. The other models either used more variables without an appreciable improvement in accuracy or had slightly lower accuracy overall. An in-clinic calculator was developed that can estimate the risk of ACL revision (Revision Risk Calculator). This calculator can quantify risk at a patient-specific level, with a plausible range from near 0% for low-risk patients to 20% for high-risk patients at 5 years.Conclusions:Machine learning analysis of a national knee ligament registry can predict the risk of ACL reconstruction revision with moderate accuracy. This algorithm supports the creation of an in-clinic calculator for point-of-care risk stratification based on the input of only 5 variables. Similar analysis using a larger or more comprehensive data set may improve the accuracy of risk prediction, and future studies incorporating patients who have experienced failure of ACL reconstruction but have not undergone subsequent revision may better predict the true risk of ACL reconstruction failure.Level of Evidence:PrognosticLevel III. See Instructions for Authors for a complete description of levels of evidence.
A Curious Case of a Wooden Toothpick Inside a Child’s Knee
Authors: Timon Charles , Baig M. N. , Diack Megan , Shannon Fintan 
Published: October 2021

Case:
A 10-year-old boy presented with vague symptoms, a few days after a nondescript injury to his left knee. History, examination and blood tests, and imaging were unremarkable. Because of his severe pain, we proceeded to arthroscopy. On proceeding to arthroscopy, a wooden toothpick was found inside the knee joint. The wooden toothpick was removed arthroscopically.

Conclusion:
The physicians/surgeons have to be vigilant and should approach holistically toward history and examination of a child presenting with vague signs and symptoms.
A Time-Continuation Solver for Hydraulic Fracture Propagation
Authors: Ren Guotong , Younis Rami M. 
Published: October 2021

Abstract
We present an efficient time-continuation scheme for fluid-driven fracture propagation problems in the frame-work of the extended finite element method (XFEM). The fully coupled, fully implicit hydro-mechanical system is solved in conjunction with the linear elastic fracture propagation criterion by the Newton-Raphson method. Therefore, at the end of each time-step solve, the model ensures the energy release rate of weakest fracture tips within the equilibrium propagation regime. Besides, an initialization procedure for newly created fracture space as well as a priori estimate of stress intensity factor (SIF) growth rates are also developed to further improve the solver performance. We validate the model by the analytical solution and extend the problem to the multiple fracture propagation where stress shadow phenomenon occur.
Theoretical Investigation of Unconditionally Stable Sequential Algorithms of Coupled Flow and Geomechanics for Hydraulically Fractured Systems
Authors: Kim Jihoon 
Published: October 2021

Abstract
We investigate unconditionally stable sequential algorithms for coupled hydraulically fractured geomechanics and flow systems, which can account for poromechanics behavior within the fractures. We focus on modifying the concepts of the fixed stress and undrained sequential methods properly for the coupled systems by taking appropriate stabilization terms for stability and convergence with energy analyses. Specifically, an apparent fracture stiffness is used for for numerical stabilization. Because this fracture stiffness depends on the fracture length, the stabilization term needs to be updated dynamically, different from the drained bulk modulus used for typical poromechanics problems. For numerical tests, we take the extended finite element method for geomechanics while the piecewise constant finite element method is used for flow within an existing hydraulic fracture. The numerical results support a priori stability analyses.