bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Weight Bias and Associated Factors on Perceptions of Plus Size Models
Authors: Miller Julia Caroline Porter , Carels Robert A. 
Published: March 2021

Abstract
Purpose: The fashion industry has recently begun to utilize plus size models. The aim of this study was to explore whether these models would be viewed more critically in comparison to thin models or subjected to weight bias and associated factors. Methods: University students (N = 330, Mage= 18.62, SDage = 1.33) viewed images of thin and plus size models and rated each image. They then filled out measures assessing weight bias (measured through the Antifat Attitudes Questionnaire), sociocultural attitudes regarding athletic and thin body types, and body appreciation. Results: Plus size models were rated more critically than thin models (p < 0.01). Thin and plus size model ratings were also highly correlated (p < 0.01), but weight bias was still predictive of plus model ratings within a regression model that included thin model ratings (p < 0.01). Further, mediational analyses found that weight bias partially mediated the relationship between thin and plus size model ratings. Males were more likely to rate both model types more critically (p < 0.01), but weight bias was found to partially mediate the relationship between male ratings of plus-sized models (p < .001). Conclusions: Despite the recent steps to include more body diversity among the fashion industry, plus size models still appear to be subjected to weight bias, especially among males. Level of Evidence: Level III, case–control analytic study.
Sex-specific DNA methylation changes in Alzheimer’s disease pathology
Authors: Zhang Lanyu , Young Juan , Gomez Lissette , Silva Tiago , Schmidt Michael , Cai Jesse , Chen Xi , Martin Eden , Wang Lily 
Published: March 2021

Abstract
Sex is an important factor that contributes to the clinical and biological heterogeneities in Alzheimer’s disease (AD), but the regulatory mechanisms underlying sex disparity in AD are still not well understood. DNA methylation is an important epigenetic modification that regulates gene transcription and is known to be involved in AD. We performed the first large-scale sex-specific meta-analysis of DNA methylation changes in AD, by re-analyzing four recent epigenome-wide association studies totaling more than 1000 postmortem prefrontal cortex brain samples using a uniform analytical pipeline. For each cohort we employed two complementary analytical strategies, a sex-stratified analysis that examined methylation-Braak stage associations in male and female samples separately, and a sex-by-Braak stage interaction analysis that compared the magnitude of these associations between different sexes. Our analysis uncovered 14 novel CpGs, mapped to genes such as TMEM39A and TNXB that are associated with AD in a sex-specific manner. TMEM39A is known to be involved in inflammation, dysregulated type I interferon responses, and other immune processes. TNXB encodes tenascin proteins, which are extracellular matrix glycoproteins demonstrated to modulate synaptic plasticity in the brain. Moreover, for many previously implicated AD genes, such as MBP and AZU1, our analysis provided the new insights that they were predominately driven by effects in only one sex. These sex-specific DNA methylation changes were enriched in divergent biological processes such as integrin activation in females and complement activation in males. Importantly, a number of drugs commonly prescribed for AD patients also targeted these genes with sex-specific DNA methylation changes. Our study implicated multiple new loci and biological processes that affected AD in a sex-specific manner and highlighted the importance of sex-specific treatment regimens for AD patients.
Development And Validation Of A Voice Script For Telephone Administration Of THE EORTC QLQ-C30
Authors: Piccinin Claire , Pe Madeline , Kuliś Dagmara , Shaw James W. , Wheelwright Sally J. , Bottomley Andrew 
Published: March 2021

Abstract
Purpose The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life-Core Questionnaire (QLQ-C30) is a widely used generic self-report measure of health-related quality of life (HRQOL) for cancer patients. However, no validated voice script for interviewer-led telephone administration was previously developed that could be used as an alternative to self-completion. The aim of this study was to develop a voice script for interviewer administration via telephone. Methods Following guidelines from the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) PRO Mixed Modes Good Research Practices Task Force, a randomised cross-over equivalence study, including cognitive debriefing, was conducted to assess equivalence between paper and telephone administration modes. Assuming an expected intraclass correlation coefficient (ICC) of 0.70 and a minimally acceptable level of 0.50, a sample size of 63 was required. Results Cognitive interviews with five cancer patients found the voice script to be clear and understandable. Due to a protocol deviation in the first wave of testing, only 26 patients were available for analyses. A second wave of recruitment was conducted, adding 37 patients (n=63; mean age 55.48; 65.1% female). ICCs for mode comparison ranged from 0.72 (nausea and vomiting, 95% CI 0.48-0.86) to 0.90 (global health status/QoL, 95% CI 0.80-0.95; pain, 95% CI 0.79-0.95; constipation, 95% CI 0.80-0.95). For paper versus phone, all ICCs were above 0.70, except nausea and vomiting (95% CI 0.55). For phone versus paper, all ICCs were above 0.70. Conclusions The equivalence testing results support the voice script’s validity for administration of the QLQ-C30 via telephone.
Future climate and land use instability can negate the benefits of protected areas
Authors: Asamoah Ernest , Beaumont Linda , Maina Joesph M 
Published: March 2021

Abstract
Expanding protected area networks and enhancing their capacities is currently one avenue at the forefront of efforts to conserve and restore global biodiversity. Climate and habitat loss resulting from land use interact synergistically to undermine the potential benefits of protected areas (PAs). Targeting conservation, adaptation and mitigation efforts requires an understanding of patterns of climate and land-use change within the current arrangement of PAs, and how these might change in the future. In this paper, we provide this understanding using predicted rates of temporal and spatial displacement of future climate and land use globally and within PAs. We show that ~ 47% of the world’s PAs—10.6% of which are under restrictive management—are located in regions that will likely experience both climate stress and land-use instability by 2050. The vast majority of these PAs are also distributed across moist biomes and in high conservation value regions, and fall into less-restrictive management categories. The differential impacts of combined land use and climate velocity across protected biomes indicate that climate and land-use change may have fundamentally different ecological and management consequences at multiple scales. Taken together, our findings can inform spatially adaptive natural resource management and actions to achieve sustainable development and biodiversity goals.
Intrinsic and specific groundwater vulnerability using the GOD method as a pre-operational baseline assessment of an unconventional hydrocarbon industry
Authors: Lima Gustavo Filemon Costa , Ferreira Vinícius Gonçalves , Lima Jussara da Silva Diniz , Duarte Joyce Castro de Menezes , Dufilho Ana Cecília , Filho Carlos Alberto de Carvalho 
Published: March 2021

Abstract
In the middle of the São Francisco basin, the sub-basins of Indaiá and Borrachudo river highlight the considerable potential for unconventional hydrocarbon exploration. The present study seeks to evaluate the groundwater resource's intrinsic and specific vulnerability in the Indaiá and Borrachudo basins as an environmental baseline study for further development in the shale gas industry. The overlay and index GOD method was applied to assess the aquifer's intrinsic susceptibility regarding the Groundwater confinement (G), the Overlying Strata (O), and the Depth of the groundwater table (D). The specific vulnerability assessment considered the intrinsic vulnerability and the land cover/use of the area, concerning the diversity and the toxicity of pollutants inherent in each anthropogenic activity. The results indicate that 52.69%, 25.12%, and 17.57% of the aquifer area have Medium, High, and Extreme intrinsic vulnerability, respectively. The specific vulnerability assessment suggests an overall vulnerability reduction due to the low anthropogenic stress on the basin. Three gas research wells overlay moderate intrinsic vulnerability. One well is above the high vulnerability area, which concerns how the unconventional industry could develop regarding groundwater susceptibility in this ecosystem.
Effects of Treated Wastewater on Vegetative Growth and Pigmentation of Forage Crops
Authors: Paul Sujatha , AL Veerabhadraswamy 
Published: March 2021

Abstract
Purpose: The present investigation was undertaken to evaluate the possibility of whether treated wastewater from industrial units could safely be used to irrigate crop plants and solve the problem of liquid effluent disposal in an eco-friendly manner. Methods: In this study select to evaluate the effects of effluents of textile, pharmaceutical and granite industry and on the germination (early growth) of selected forage crops like Sorghum bicolor, Pennisetum typhoideum and Hordeum vulgare. The present investigation involves the analysis of soil, water and plant analysis like chlorophyll, cartorenoids and growth. Results: The results revealed that pH, EC and chlorides and several other parameters were within the usual range of water used for irrigation purposes. The percentage of germination and vigor index was maximum for bajra and barley. The physico-chemical parameters of soil and wastewater were found to be within the usual range of tolerance limits for the industrial effluent on land prescribed by BIS except for TSS and hardness in some samples. The germination percentage and vigor index of jowar, bajra and barley were higher in granite industry water samples. The plant length of all crop samples had significant heights in all the samples. The total chlorophyll and carotenoid content were also found to be significant amounts in the leaf samples of all the crops grown in different water samples. Conclusion: Treated wastewater can be a prospective source of organic matter and nutrients that could increase the quality of soil, thus may be a beneficial alternative resource to freshwater for irrigation purposes in the offseason. Hence there are great possibilities for growing highly profitable forage crops using treated wastewater in the offseason.
The emission reduction effect of environmental information disclosure: a Chinese city perspective
Authors: Yu Weihua , Jin Xin 
Published: March 2021

Abstract
To address the problem of air pollution caused by industrialization and urbanization, China has issued various types of policies related to environmental protection. However, policies regarding environmental information disclosure have long-term advantages in reducing information asymmetry and improving regulatory efficiency, and are selected as the research objects of this paper. Using the "Environmental Information Disclosure Measures (Trial)" in 2008 as a quasi-natural experiment, our analysis utilizing the difference-in-differences method shows that (1) as the quality of environmental information disclosure increase, the production and emission of sulfur dioxide decrease, and this relationship is robust to different specifications; (2) a possible channel composed of green patents and the pollution source information and treatment information (PITI) disclosure index has a same-direction moderating effect on the reduction of pollutants; and (3) our findings are particularly pronounced in subsamples of large-scale and resource-intensive cities. Overall, this paper reveals micro evidence on the effects of environmental information disclosure policy on the reduction of pollutants, thus providing timely insights for the further improvement and implementation of the policy.
The metabolic effects of multi-trace elements on parenteral nutrition for pediatric patients: A Randomized Control Trial and Metabolomic Research
Authors: Tan Qingti , Wang Yu , Zhang Guoying , Lu Bin , Wang Tao , Tao Tao , Wang He , Jiang Hua , Chen Wei 
Published: March 2021

Abstract
Objectives: The recommended dose of multi-trace element injection Ⅰ (MTEI-(Ⅰ)), and the effects of MTEI-(Ⅰ) on nutrient metabolism were investigated by supplementing different doses of multi-trace element parenteral nutrition (PN) to severe pediatric subjects. Methods: Enrolled subjects were randomly divided into two groups: Group A (low-dose group) received MTEI-(I) at 1 mL/kg/d, and Group B (high-dose group) received MTEI-(I) at 2 mL/kg/d, with a maximum dose of 15 mL/d. Patient blood samples before PN, and five day after treatment were collected for trace element detection and metabolomics analyses. Results: After 5 days treatment, white blood counts (WBC), nitrogen (N), chromium (Cr), total bilirubin (TB), direct bilirubin (DB) and albumin (ALB) levels in both groups were variably decreased; of which, WBC (p=0.011) and Cr (p=0.007) levels of subjects in Group B were significantly decreased; Overall, after 5 days of treatment, manganese (Mn) and copper (Cu) levels were decreased, zinc (Zn) and selenium (Se) levels were increased. The increase of Zn (A: 0.170±0.479 VS B：0.193±0.900)and decrease of Cu (A: -0.240±0.382 VS B: -0.373±0.465) of subjects in group B were particularly greater than those in group A. After 5 days treatment, valine, leucine, isoleucine degradation (α-ketoisovaleric acid) products, taurine and hypotaurine metabolism (hypotaurine), arginine and proline metabolism (phosphocreatine), ketone body metabolism (acetoacetic acid and acetone), and other metabolic outputs were decreased (p＜0.05). For Group B, β-oxidation of very long chain fatty acids (hexacosanoic acid), arginine and proline metabolism (phosphocreatine), pentose phosphate metabolism (D-ribose), ketone body metabolism (acetone), citric acid cycle (succinic acid), purine metabolism (adenine), caffeine metabolism (dimethylxanthine) and pyruvate metabolism (acetyl phosphate) were variably decreased (p＜0.05) when compared with Group A at T5. Conclusions: Our work suggested that the high-dose administration of MTEI-(I) is safe for severe pediatric patients. It may alleviate inflammation and antioxidation, relieved hyper caused by stress, improved tissues-based hypoxia, and improved renal function. (Trial registration: ChiCTR-IPR-17013037. Registered 19 October 2017, http://www.chictr.org.cn/showproj.aspx?proj=22327)
Contrasting structural complexity differentiate hunting strategy in an ambush apex predator
Authors: Říha Milan , Gjelland Karl Ø. , Děd Vilém , Eloranta Antti P. , Rabaneda-Bueno Ruben , Baktoft Henrik , Vejřík Lukáš , Vejříková Ivana , Draštík Vladislav , Šmejkal Marek , Holubová Michaela , Jůza Tomas , Rosten Carolyn , Sajdlová Zuzana , Økland Finn , Peterka Jiří 
Published: March 2021

Abstract
Structural complexity is known to influence prey behaviour, mortality and population structure, but the effects on predators has received less attention. We tested whether contrasting structural complexity in two newly colonised lakes (low structural complexity lake – LSC; high structural complexity - HSC) was associated with contrasting behaviour in an aquatic apex predator, Northern pike (Esox lucius; hereafter pike) present in the lakes. Behaviour of pike was studied with whole-lake acoustic telemetry tracking, supplemented by stable isotope analysis of pike prey utilization and survey fishing data on the prey fish community. Pike displayed increased activity, space use, individual growth as well as behavioural differentiation and spent more time in open waters in the LSC lake. Despite observed differences between lakes, stable isotopes analyses indicated a high dependency on littoral food sources in both lakes. We concluded that pike in the HSC lake displayed a behaviour consistent with a prevalent ambush predation behaviour, whereas the higher activity and larger space use in the LSC lake indicated a transition to more active search behaviour. It could lead to increased prey encounter and cause better growth in the LSC lake. Our study demonstrated how differences in structural complexity mediated prominent changes in the foraging behaviour of an apex predator, which in turn may have effects on the prey community.
Physiological and transcriptomic analyses reveal novel insights into the cultivar-specific response to alkaline stress in alfalfa (Medicago sativa L.)
Authors: Wei Tian-Jiao , Li Guang , Wang Ming-Ming , Jin Yang-Yang , Zhang Guo-Hui , Liu Miao , Yang Hao-Yu , Jiang Chang-Jie , Liang Zheng-Wei 
Published: March 2021

Abstract
Key message Candidate pathways for alkaline tolerance in alfalfa seedlings were identified; these included those for homeostasis of ions and redox status, biosynthesis of phenylpropanoids, flavonoids, and amino acids, and MAPK signaling.Abstract Soil alkalization severely limits plant growth and development; however, the mechanisms of alkaline response remain largely unknown. In this study, we performed physiological and transcriptomic analyses using two alfalfa cultivars (Medicago sativa L.) with different sensitivities to alkaline conditions. The chlorophyll content and shoot fresh weight drastically declined in the alkaline-sensitive cultivar Algonquin (AG) following alkaline treatment (0-25 mM Na2CO3 solution), while the alkaline-tolerant cultivar Gongnong NO.1 (GN) maintained relatively stable growth and chlorophyll content. Physiological analysis revealed that compared with AG, GN had higher contents of Ca2+ and Mg2+; the ratios of Ca2+ and Mg2+ to Na+, proline and soluble sugar, and enzyme activities of peroxidase (POD) and catalase (CAT) decreased under the alkaline conditions. Further, transcriptomic analysis identified three categories of alkaline-responsive differentially expressed genes (DEGs) between the two cultivars: 48 genes commonly induced in both the cultivars (CAR), 574 genes from the tolerant cultivar (TAR), and 493 genes from the sensitive cultivar (SAR). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses showed that CAR genes were mostly involved in phenylpropanoid biosynthesis, lipid metabolism, and DNA replication and repair; TAR genes were significantly enriched in metabolic pathways, biosynthesis of secondary metabolites, MAPK signaling pathway, and flavonoid and amino acid biosynthesis; the SAR genes were specifically enriched in vitamin B6 metabolism. Taken together, the results identified candidate pathways associated with genetic variation in response to alkaline stress, providing novel insights into the mechanisms underlying alkaline tolerance in alfalfa.
Effect of Mn doping on structure, the dielectric and electric properties of BCZT ceramics
Authors: Ismail Khmiri , KRIAA Issa , KHEMAKHEM Hamadi 
Published: March 2021

Abstract
The synthesis of (Ba 0.99 Ca 0.01 )(Zr 0.2 Ti 0.8 )O 3 (BCZT) and doped (Ba 0.99 Ca 0.01 )(Zr 0.2 Ti 0.8-x Mn x )O 3 (BCZT-xMn) ceramics was successfully carried out by the solid-state method. The doping effect is followed by X-ray powder diffraction, scanning electron microscopy (SEM), and dielectric and conductivity measurements. Indeed, X-ray diffraction measurements show the crystalline structure of ceramics. SEM images indicate the doping effect on the studied perovskite microstructure. The results indicate that during doping the maximum value of the temperature (Tm) of the dielectric constant varies slightly, and there will be a considerable decrease in permittivity, dielectric losses and conductivity. Manganese ions are well integrated in the perovskite while maintaining the solid solution.
Bio-efﬁcacy of entomopathogenic nematodes, Steinernema feltiae and Heterorhabditis bacteriophora against the Cabbage butterfly Pieris brassicae (L.), under laboratory conditions
Authors: Kumar Kasi Indra , Singh Mohinder , Waiba Kanchhi Maya , Monika Sharma , Waseem MA , Gilhotra Himanshu 
Published: March 2021

Abstract
BACKGROUND: Keeping in view the serious health and environmental apprehensions associated with the use of pesticides, entomopathogenic nematodes have the potential to supersede larvicidal activity for the management of various insect pests. RESULT: The lab experiments were conducted to test the pathogenicity of two EPNs species S. feltiaeand H. bacteriophora at different (IJs/cm2) concentrations against cabbage pests. Based on the pathogenicity of strains, only two isolates effectively show larvicidal activity. The native isolate was obtained from soil samples, collected from Rajgarh, Hamachi Pradesh, India. Petri dish bioassay use nematodes S. feltiae HR1 and H. bacteriophora HR2 species dose (0, 10, 20, 40, 80, 160/ IJs/cm2). The highest (%) 2nd instar larval mortality was recorded in treatments with H. bacteriophora and S. feltiae @ 160 /IJs/cm-2 were (72.08, 67.42 percent). And 4th instar larval mortality was recorded in treatment with H. bacteriophora, and S. feltiae @ 160 /IJs/cm-2 were (85.38,69.50 percent). The next best treatments in order of their efficacy’s pupae mortality were H. bacteriophora and S. feltiae @ 160 /IJs/cm-2 (74.12, percent) both are seam result, H. bacteriophora and S. feltiae @ 80 /IJs/cm-2 (62.12, 58.58 percent). Larvicidal activity after 48- and 72-hours exposure, the S. feltiae and H. bacteriophora (1.0, 1.30, 1.60, 1.90, 2.20 /IJs/cm2) showed potent larvicidal activity with LC50, LC75 and LC90 of all instars and pupae show high mortality. The strain inhibits the larval and pupal development 48 to 72 hr exposer time with LC50 range from 11.30 to 39.94, LC75 18.15 to 73.54, LC90 61.80 to 99.21.CONCLUSION: These studies demonstrate the challenge for cabbage butterfly P. brassicae. The local indigenous strains of EPNs (S. feltiae HR1, H. bacteriophora HR2) as a good biocontrol agent against, cruciferous vegetables crop pest P. brassicae.
Molecular Docking of Biosynthesized Zinc Oxide Nanoparticles to Screen Their Impact on Fungal Pathogen of Carrot Plant
Authors: Khan Masudulla , Khan Azhar U. , Alam Javed , Parveen Aiman , Moon Il-Soo , Alam Mahboob , Cabral-Pinto Marina MS , Ahamed Maqusood , Yadav Virendra Kumar , Yadav Krishna 
Published: March 2021

Abstract
Zinc plays a key role in plants growth and application of Zinc can, therefore, contribute to crop yield improvement. Nowadays, nanoparticles have received high attention because to their novel properties. The current work is done with an aim to investigate the biosynthesis of zinc oxide nanoparticles (ZnO NPs) and effect on fungus Rhizoctonia solani and on carrot crop. Use of nanoparticles as a nano-fertilizer requires an understanding of nanoparticles impact on crop plants We have used seed coat of almond for the synthesis of zinc oxide nanoparticles (ZnO NPs) characterized by EDS, FTIR, SEM and TEM. Spray with 50ppm and 100 ppm caused significant increase in plant growth parameter of carrot plants. It has been reported that the synthesized ZnO NPs demonstrated an inhibitory activity against plant pathogenic fungi R. solani. Antifungal efficiency of ZnONPs was further explained with help of Molecular docking analysis. Confirmation of the least binding energy was used to predict binding site of receptor with NPs to know mechanistic approach. ZnONPs are likely to interact with the pathogens by mechanical enfolding which may be one of the major toxicity actions against R. solani by ZnONPs.