bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cutaneous Acceptability And Hydratation of Topical Products In Patients Undergoing Radiotherapy and Antineoplastic Treatment
Authors: Machado-Filho Carlos D'App Santos , Silva Odimila Kawahata Adriano , Lamas Silvia Regina 
Published: May 2021

RESUMO
Background: New antineoplastic agents have increased the survival rate of cancer patients, however, the incidence of cutaneous skin toxicity, which leads to worsening in the quality of life and to the necessity of interrupting the treatment, continues presently. Natural agents, as Aloe vera and Calendula, have been suggested as potential ways of prevention and treatment for radiation dermatitis resulting from radiotherapy, providing better adhesion to the therapies and improving the wellbeing of the patients.
Purpose: To evaluate the cutaneous acceptability and hydrating effect of four topical test products in patients undergoing radiotherapy and antineoplastic treatment.
Methods: Both sex participants, undergoing oncological treatments, were included. Patients received a prescription to self-applied topical test products - A (Washcare), B (Moistcare), C (Extremecare) and D (Coolcare Mask) during 30 days. Products acceptability and skin hydration were evaluated considering the occurrence of skin adverse reaction, participants self-reported feelings of skin discomfort, dermatologist and instrumental skin hydration evaluation.
Results: Thirty-three participants initiated and completed the study. None of them had skin reactions or discomfort in the area of application, and no adverse events were reported. Twenty-five participants (75.8%) reported improvement in skin hydration after using the test products, while eight participants (24.2%) observed the maintenance of hydration (p<0,005).
Conclusion: The products evaluated showed improvement in skin condition in most patients, increased hydration and good skin acceptability in patients with skin toxicities caused by the cancer treatments.
Recommendations of the BSSO for patients with hepatobiliary cancers in the context of COVID-19 epidemic 2020
Authors: Vieira Victor Hugo Ribeiro , Diniz Alessandro Landskron , Oliveira Alexandre Ferreira , Ribeiro Heber Salvador de Castro , Bredt Luis Cesar , Fernandes Paulo Henrique de Sousa , Ribeiro Reitan , Correia Mauro Monteiro 
Published: May 2021

ABSTRACTSince the first report in Hubei, China, COVID-19 rapidly spread throughout the world and the World Health Organization (WHO) declared COVID-19 as global Pandemic on March 11, 2020. The first confirmed case in Brazil was on February 26, 2020. These outbreaks pose a greater threat to patients with cancer in terms of morbidity and mortality as well as for the healthcare system professionals. The purpose of this editorial/letter is to provide specialist based recommendations for the treatment of hepatobiliary tumors during the pandemic period.
Treatment outcomes for adult patients with localized osteosarcoma treated with chemotherapy without methotrexate at a public hospital in Brazil
Authors: Minguete-e-Silva Marilia Polo , Bonadio Renata Rodrigues da Cunha Colombo , Matos Gustavo , Toloi Diego de Araújo , Munhoz Rodrigo Ramella , Nardo Mirella , Rebolledo Daniel , Correa Luiz Filipe Marques , Baptista Andre Mathias , Zampieri Caroline Chaul de Lima Barbosa , Feher Olavo , Camargo Veridiana Pires de 
Published: May 2021

ABSTRACT
Introduction: Standard treatment for pediatric patients with localized osteosarcoma includes high-dose methotrexate (HDMTX), and cure rates greater than 60% are observed. However, in adult patients, the toxicity profile limits the use of HDMTX and the drug is usually excluded from chemotherapy protocols for this group. We aimed to evaluate the outcomes of adult patients with localized osteosarcoma treated with chemotherapy without methotrexate. Methods: In this retrospective cohort, we evaluated adult patients with high-grade osteosarcoma who received chemotherapy treatment without methotrexate in a reference cancer center from 2007 to 2018. Outcomes analyzed were recurrence-free survival (RFS), overall survival (OS), and prognostic factors associated with overall survival. Results: A total of 48 patients had localized disease and received treatment with chemotherapy without methotrexate. The majority of them received chemotherapy with a combination of cisplatin and doxorubicin (n=42, 87.5%). Median age was 27 years (range 16.8-66.7). With a median follow-up of 29.2 months, median RFS was 29.9 months. Median OS was not reached. 5-year RFS and OS rates were 35.1% (95% CI: 20.3-50.2%) and 71.6% (95% CI: 52.3-84.2%), respectively. Patients who received cumulative doses of doxorubicin =375mg/m2 had better OS than those who received lower doses (HR 0.26, 95% CI: 0.07-0.94, p=0.041). Similarly, patients who received =6 cycles of neoadjuvant/adjuvant cisplatin tended to have better OS than those who received <6 cycles (HR 0.30, 95% CI: 0.081.09, p=0.069). Nineteen patients received less than 6 cycles of cisplatin and doxorubicin mainly because of grade 3 or 4 toxicities (11), disease progression (6), patient refusal (1), and physician choice (1). Conclusion: In our study, adult patients with localized highgrade osteosarcoma treated with chemotherapy without methotrexate had unfavorable outcomes. The cumulative doxorubicin dose and the number of cisplatin/doxorubicin cycles were associated with improved OS. The investigation of additional treatment strategies is of utmost importance to improve adult patients' outcomes.
Cancer patients diagnosed with COVID-19 infection: a multicenter retrospective cohort of nine Brazilian cancer centers
Authors: Monteiro Mariana Ribeiro , Almeida Kaique Ferreira Costa de , Abrahão Ana Beatriz Kinupe , Souza Camila Brambilla de , Carmo Rafael Luis Moura Lima do , Andrade Maria Clara Borges de , Freitas Tuane Borges do Livramento , Longo Cecilia Lameirinhas , Perdigão Maria Carolina Lopes , Ferreira Cynthia Lemos , Sousa Tercia Tarciane Soares de , Maiolino Angelo , Cruz Sueli Monterroso da , Piotto Gustavo Henrique Munhoz , Vieira Fernando Meton de Alencar Camara , Araujo Luiz Henrique 
Published: May 2021

ABSTRACT
Objectives: The COVID-19 infection was declared pandemic in March 2020. Since then, multiple studies have attempted to correlate clinical factors with the risk of complications from COVID-19. However, cancer patients are underrepresented in clinical trials and the results vary between different cohorts. Our goal is to describe a cohort of cancer patients and COVID-19. Methods: We conducted a multicenter retrospective study, based on a systematic review of medical records, including nine cancer centers, located in five different Brazilian cities. Patients were diagnosed with COVID-19 through RT-PCR between March 15th, 2020, and August 13th, 2020. Poisson regression models were then used to test for an association between clinical characteristics and severity of COVID-19 infections. Results: 102 patients had data collected for analysis, 85 (83.3%) of whom were hospitalized due to complications from COVID-19 infection. The median age was 65.8 years, most were female patients (61.8%) and white (73,5%). 78.4% had a performance status of 0-1, and the most common cancer subtypes were gastrointestinal (30.4%), breast (22.6%), and hematological (13.7%). Almost 40% of the population had stage IV disease. The mortality rate for all hospitalized patients was 36.5%, while that for those admitted to ICU was 68.4%. Key univariable risk factors for mortality included age (RR 1.03), ECOG = 2 (RR 1.83), hypertension (RR 1.72), lung metastasis (RR 1.67), and lymphocytes = 1000 admission (RR 2.40). At the multivariable analysis, the risk factors were also age (RR 1.02), primary lung cancer (RR 2.61), lung metastasis (RR 2.86), and coronary disease (RR 3.76). Conclusions: Despite the high mortality of patients hospitalized with COVID-19, cancer is a heterogeneous disease and some risk factors should be considered as the main responsible for the worst prognosis. Cancer patients should be carefully monitored in pandemic periods of infectious diseases and their management must be individualized.
A novel multi-class imbalanced EEG signals classification based on the adaptive synthetic sampling (ADASYN) approach
Authors: Alhudhaif Adi 
Published: May 2021

Background
Brain signals (EEG—Electroencephalography) are a gold standard frequently used in epilepsy prediction. It is crucial to predict epilepsy, which is common in the community. Early diagnosis is essential to reduce the treatment process of the disease and to keep the process healthier.

Methods
In this study, a five-classes dataset was used: EEG signals from different individuals, healthy EEG signals from tumor document, EEG signal with epilepsy, EEG signal with eyes closed, and EEG signal with eyes open. Four different methods have been proposed to classify five classes of EEG signals. In the first approach, the EEG signal was first divided into four different bands (beta, alpha, theta, and delta), and then 25 time-domain features were extracted from each band, and the main EEG signal and these extracted features were combined to obtain 125-time domain features (feature extraction). Using the Random Forests classifier, EEG activities were classified into five classes. In the second approach, each One-Against-One (OVO) approach with 125 attributes was split into ten parts, pairwise, and then each piece was classified with the Random Forests classifier. The majority voting scheme was used to combine decisions from the ten classifiers. In the third proposed method, each One-Against-All (OVA) approach with 125 attributes was divided into five parts, and then each piece was classified with the Random Forests classifier. The majority voting scheme was used to combine decisions from the five classifiers. In the fourth proposed approach, each One-Against-All (OVA) approach with 125 attributes was divided into five parts. Since each piece obtained had an imbalanced data distribution, an adaptive synthetic (ADASYN) sampling approach was used to stabilize each piece. Then, each balanced piece was classified with the Random Forests classifier. To combine the decisions obtanied from each classifier, the majority voting scheme has been used.

Results
The first approach achieved 71.90% classification success in classifying five-class EEG signals. The second approach achieved a classification success of 91.08% in classifying five-class EEG signals. The third method achieved 89% success, while the fourth proposed approach achieved 91.72% success. The results obtained show that the proposed fourth approach (the combination of the ADASYN sampling approach and Random Forest Classifier) achieved the best success in classifying five class EEG signals. This proposed method could be used in the detection of epilepsy events in the EEG signals.
The relationship between PLOD1 expression level and glioma prognosis investigated using public databases
Authors: Tian Lei , Zhou Huandi , Wang Guohui , Wang Wen yan , Li Yuehong , Xue Xiaoying 
Published: May 2021

Background
Glioma is the most common type of intracranial tumor with high malignancy and poor prognosis despite the use of various aggressive treatments. Targeted therapy and immunotherapy are not effective and new biomarkers need to be explored. Some Procollagen-lysine 2-oxyglutarate 5-dioxygenase (PLOD) family members have been found to be involved in the metastasis and progression of tumors. Both PLOD2 and PLOD3 had been reported to be highly expressed in gliomas, while the prognostic value of PLOD1 remains to be further illustrated, so we want to investigate the PLOD1 expression in glioma and its clinical implication.

Methods
We collected gene expression and corresponding clinical data of glioma from the Chinese Glioma Genome Atlas (CGGA) database, The Cancer Genome Atlas (TCGA) database and the Gene Expression Omnibus (GEO) database. First, we analyzed the expression and mutation of PLOD1 in gliomas and its relationship with clinicopathologic characteristics. Then, we conducted survival analysis, prognostic analysis and nomogram construction of the PLOD1 gene. Finally, we conducted gene ontology (GO) enrichment analysis and gene set enrichment analysis (GSEA) to explore possible mechanisms and gene co-expression analysis was also be performed.

Results
The results showed that the expression level of PLOD1 was higher in gliomas than normal tissues, and high expression of PLOD1 was related to poor survival which can serve as an oncogenic factor and an independent prognostic indicator for glioma patients. Both the GO and GSEA analysis showed high expression of PLOD1 were enriched in Extracellular matrix (ECM) related pathways, the co-expression analysis revealed that PLOD1 was positively related to HSPG2, COL6A2, COL4A2, FN1, COL1A1, COL4A1, CD44, COL3A1, COL1A2 and SPP1, and high expression of these genes were also correlated to poor prognosis of glioma.

Conclusions
The results showed that high expression of PLOD1 leads to poor prognosis, and PLOD1 is an independent prognostic factor and a novel biomarker for the treatment of glioma. Furthermore, targeting PLOD1 is most likely a potential therapeutic strategy for glioma patients.
A Comprehensive Study of Kernel (Issues and Concepts) in Different Operating Systems
Authors: Malallah HayfaaSubhi , Zeebaree Subhi R. M. , Zebari Rizgar R. , Sadeeq Mohammed A. M. , Ageed Zainab Salih , Ibrahim Ibrahim Mahmood , Yasin Hajar Maseeh , Merceedi Karwan Jameel 
Published: May 2021

Various operating systems (OS) with numerous functions and features have appeared over time. As a result, they know how each OS has been implemented guides users' decisions on configuring the OS on their machines. Consequently, a comparative study of different operating systems is needed to provide specifics on the same and variance in novel types of OS to address their flaws. This paper's center of attention is the visual operating system based on the OS features and their limitations and strengths by contrasting iOS, Android, Mac, Windows, and Linux operating systems. Linux, Android, and Windows 10 are more stable, more compatible, and more reliable operating systems. Linux, Android, and Windows are popular enough to become user-friendly, unlike other OSs, and make more application programs. The firewalls in Mac OS X and Windows 10 are built-in. The most popular platforms are Android and Windows, specifically the novelist versions. It is because they are low-cost, dependable, compatible, safe, and easy to use. Furthermore, modern developments in issues resulting from the advent of emerging technology and the growth of the cell phone introduced many features such as high-speed processors, massive memory, multitasking, high-resolution displays, functional telecommunication hardware, and so on.
Chemical Peeling: Indications, Side-Effects and Outcome among Patients at a Private Clinic in Port Harcourt
Authors: Otike-Odibi Bolaji I. , Altraide Dasetima D. 
Published: May 2021

Background: Chemical peeling is a technique that aims to achieve rejuvenation of the skin by application of chemical peels. The technique dates back to several decades, yet little is known about the indication, side-effects and outcome among a Nigerian population.
Purpose: The aim of the study was to assess the type of chemical peels, their indication, side –effects and outcome among patients at a private dermatology clinic.
Materials and Methods: This was a retrospective study, which employed a pro forma to obtain data required to attain the objectives. Data were obtained from all patients who underwent chemical peeling. Chi square and student t test were determined at a statistically significant level of 0.05.
Results: The study had a total of twenty-seven patients, comprising of 7 (25.9%) males, and 20 (74.1%) females, who underwent chemical peeling. Superficial chemical peel was the most dominant peel method (81.5%). Among the superficial peel, mandelic peel, salicylic peel and glycolic peel were commonly. Five of the patients (18.5%) received medium depth, and none (0%) received deep chemical peel. The most frequent indication among the patients in the study was Acne Vulgaris (55.6%), followed by Melasma (14.8%). The comparison of treatment outcome on clinical improvement by age, sex and category of chemical peel revealed no significant differences. Two of the patients reported side-effects (7.4%) namely skin dryness and hyperpigmentation.
Conclusion: Chemical peeling among Nigerian population has few side-effects and is effective. Acne is the most common indication for chemical peel. There is a need for further studies employing analytic study designs and involving a larger population.
Correlates and Pattern of Psychiatric Morbidity among Patients attending the Dermatological Clinic of a Tertiary Hospital in South-South Region of Nigeria
Authors: Otike-Odibi Bolaji , Okeafor Chukwuma U. , Altraide Dasetima D. 
Published: May 2021

Introduction: Higher rates of psychiatric disorders have been reported among patients with dermatological lesions. These problems could negatively impact the quality of life of these patients.
Objectives: The study aimed to assess the psychiatric morbidity among patients attending the dermatology clinic of University Port Harcourt Teaching Hospital (UPTH). It also sought to assess the relationship between socio-demographic factors and presence of psychiatric morbidity.
Methodology: The study employed a cross-sectional design, involving ninety patients consecutively recruited from the dermatology clinic of University of Port Harcourt Teaching Hospital (UPTH). Consenting patients filled the study questionnaire which was inclusive of a socio-demographic questionnaire and general health questionnaire (GHQ-12). A GHQ score of ≥3 was considered as having psychiatric morbidity. Statistical analysis was performed at a statistical significance level of 0.05.
Results: The mean age (±Standard deviation) of the patients was 32.3(±13.2) years. The study had a male to female ratio of 1:2.2. Psychiatric morbidity was noticed in 34 patients giving a prevalence rate of 37.8%. The prevalence of psychiatric morbidity was higher among females (40.3%) in comparison to males (32.1%), but this difference was not statistically significant (P=0.459). Age (P=0.840) and duration of dermatological disorder (P=0.211) showed no significant relationship with psychiatric morbidity.
Conclusion: This study has shown that psychiatric conditions are common among patients with dermatological lesions. Hence it is necessary that mental health care is considered in the routine management of these patients.
Awareness of Retinopathy among Sickle Cell Patients
Authors: Alruwaili Shahad , Aleliwi Yasser , Mahfud Shahd Al , Alshehri Mohammad , Ghathber Hamad Al , Alamri Abdullah 
Published: May 2021

Background: Sickle cell disease (SCD) is a haemoglobinopathy that is inherited in an autosomal recessive pattern. Retinopathy is a complication of SCD, which varies from mild peripheral retinopathy to severe proliferative retinopathy that can cause loss of vision.
Methods: A cross-sectional study was conducted from June 2020 to January 2021 aiming to determine the knowledge of retinopathy among patients with sickle cell disease using a validated self-administered questionnaire.
Result: A total of 166 respondents completed the questionnaire. Females constituted the majority of participants (62.7%). The age group 31–40 years consitituted 28.3% and were associated with higher knowledge scores. The average knowledge score was also significantly higher in respondents from the Eastern region (B = 1.82, P < 0.05) compared to respondents from Riyadh. The main reason for not having an eye check was the perceived lack of importance of visits among 56.8%.
Conclusion: Sickle cell disease patients are prone to complications such as retinopathy which can be detected by frequent follow-up. Almost half of the studied sample showed above average knowledge of retinopathies related to sickle cell disease.
Impact of Natural Products on Developing New Treatments for Corona Virus Disease (COVID-19): Review
Authors: Saddiq Amna A. , Danial Enas N. , Saraf Iman  A. 
Published: May 2021

COVID-19 is dominatingly considered as an unavoidable pandemic, and researchers are exceptionally inquisitive about how to give the best assurance to people in general before an immunization can be made accessible. Normal items have consistently assumed an essential part in drug advancement measure against different illnesses, which brought about screening of such specialists to battle emanant freaks of infections. Contingent upon the construction, component of activity and hazard elements of Covid-19, this audit centers around those normal mixtures that showed promising outcomes against Corona infections. Although restraint of viral replication is frequently considered as an overall component for antiviral action of many of the characteristic items, contemplates have shown that some regular items can connect with key viral proteins that are related with destructiveness. Supplementation of natural products might be a affect to reduce risk through different mechanisms.
In this unique circumstance, a portion of the regular items have antiviral action in the nanomolar fixation and could be leads for additional medication advancement all alone or as a format for drug plan. Also, a decent number of normal items with against Covid action are the significant constituents of some regular dietary enhancements, which can be abused to improve the resistance of everyone in specific scourges The candidate compounds identified by us may help to speed up the drug development against COVID-19.
Demographic impact of landfill closure on a resident opportunistic gull
Authors: Delgado Sergio , Herrero Alfredo , Galarza Aitor , Aldalur Asier , Zorrozua Nere , Arizaga Juan 
Published: May 2021

AbstractThe management of mixed municipal waste can have an impact on wildlife and ecosystems. Previous studies have investigated how opportunistic species like gulls can react very fast to new landfills; however, the impact of landfill closure on bird populations is less investigated. Yet, there is a need to understand how fast and to what extent, animal populations can be adapted to new scenarios where the waste will not be deposited in landfill sites anymore. The aim is to determine the influence of landfill closures on apparent survival of a resident Yellow‐legged Gull (Larus michahellis) population, used as a model species showing short‐distance foraging movements, and with a high dependence on local food subsidies. Complementarily, we built some basic population growth models in order to determine how potential changes in survival (before/after landfill closure) will impact on population growth rate. Using a data set of 4,437 Yellow‐legged Gull chicks ringed in four colonies over a period of 13 years, we obtained evidence supporting that the apparent survival was affected by landfill closure, especially if the landfill was located within a buffer of 10 km around the colony. Landfill closure affected the survival of first‐year gulls (with a mean decrease of ~ 0.5–0.36), but not of older birds. Consequently, we did not detect a remarkable effect of landfill closures on population growth rate, probably due to the lack of effect on adult survival rates except for one of the surveyed colonies, where we found an annual decline of 7%.