bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Evaluation of Antimicrobial Efficacy of Five Different Herbal Solutions: Propolis, Azadirachta Indica (Neem), Triphala, Green Tea, and Turmeric against Enterococcus Faecalis and Debris Removal from the Root Canal Using Two Irrigation Protocols—Manual and Ultrasonic—An Ex Vivo Study
Authors: Jain Omni P. , Lairenlakpam Ronel , Priya Pallavi , Chouhan Vidhur , Anand Karishma , Dhandoria Deepika 
Published: December 2024

ABSTRACT

Aim:
To assess the objectives are to assess and contrast the antibacterial activity of neem, propolis, triphala, turmeric, and green tea as well as the effectiveness of these substances in clearing root canal debris in the presence and absence of passive ultrasonic irrigation.

Methodology:
Techniques, such as neem, propolis, triphala, turmeric, and green tea, were tested for antibacterial activity using enterococcus faecalis (ATCC-24212) as a test organism and an agar diffusion test. The negative control group was saline.

Results:
A total of 240 removed human mandibular permanent teeth were utilized to assess the effectiveness of the debris removal process. From the CEJ, they received decoronation. After that, they were split into 12 smaller groups based on whether passive ultrasonic stimulation was employed throughout the irrigation technique.

Conclusion:
Propolis and triphala had the highest antibacterial activity against enterococcus faecalis. Turmeric had the most efficiency in removing debris from the root canal, followed by propolis, and saline had the least amount. Using all six test irrigants, the debris removal effectiveness was increased by passive ultrasonic irrigation.
Perception and Awareness of Diabetes Mellites and Diabetes Ketoacidosis among the General Population in Sudair Area, Saudi Arabia
Authors: Alanazi Yousef A. , Alsaadoon Bandar M. B. , Alanazi Talal M. A. , Alanazi Abdulaziz M. A. , Alsaadoon Sultan M. B. , Alanazi Majeed G. I. , Almutairi Abdulrahman N. N. , Alanazi Khalid F. , Shaik Riyaz A. , Mohamed Elsadig Y. 
Published: December 2024

ABSTRACT

Background:
This study was carried out to assess the level of knowledge and awareness of diabetes and DKA among the general population in the Sudair area of Saudi Arabia.

Methods:
This cross-sectional study was conducted among the individuals of Sudair area, Saudi Arabia (both Saudi and non-Saudi). The inclusion criteria were individuals who live in Sudair area of both gender and older than 18 years of age. The data will be collected by filling out a pre-designed online questionnaire that has choice answers. Data were analyzed by using SPSS version 24 and presented in tables.

Results:
There were 709 people who participated in the study; majority of the participants were educated with 368 (51.9%) being University passed out. The majority of the older people believed that diabetic ketoacidosis is dangerous and may cause death. (P < 0.05). People aged less than 30 preferred calling an ambulance immediately 31 (46.9%) rather than taking them to the emergency room when asked about their opinion on a situation if one of their relatives or friends is afflicted with acidity in the blood. (P < 0.05).

Conclusion:
Awareness of diabetic ketoacidosis (DKA) is low in the Sudair area, though higher among older, more educated, and married individuals. Targeted, multi-channel educational efforts and strong collaboration among healthcare providers, community leaders, and educational institutions are essential to improve understanding and reduce DKA-related health risks.
Comparative Evaluation of Fluid Absorbency of Retraction Cord after Immersing in Two Alpha Adrenomimetic Medicaments—An In Vitro Study
Authors: Gurunathan Balamurugan , Rahangdale Tripty , Parpiyani Manisha , Ninan Reny K. , Dhamane Arsh , Raghav Shivangi 
Published: December 2024

ABSTRACT

Aim:
The aim was to compare and evaluate the fluid absorbency of retraction cord after immersing in ZOAMETTM nasal decongestant and VIZOLINETM eye decongestant.

Material and Method:
A total of 90 pieces, each 50 mm long, were divided into three groups of 30. Group 1 consisted of untreated cords, while Groups 2 and 3 involved cords immersed in both solutions for 20 minutes, respectively. Further subgroups were divided based on immersion in artificial saliva and plasma. When immersed in medicaments, a significant difference in the absorption of fluids (artificial saliva and plasma) and between the two solutions was observed.

Result and Conclusion:
It was concluded that both the agents are safe to be used for gingival retraction; among the two, VIZOLINETM gave more efficient results.
Efficacy of a Single Trapezoidal-Shaped 3-D Condylar Plate in the Osteosynthesis of Mandibular Condylar Fractures
Authors: Pillania Ashish , Guruprasad Yadavalli , Butoliya Pooja , Butoliya Arti , Bhakar Khushbu Lamba , Deshmukh Abhinay V. , Singh Chandandeep 
Published: December 2024

ABSTRACT

Aim:
In the osteosynthesis of mandibular condylar fractures, the goal had been to assess the stability of a single trapezoidal-shaped 3-D condylar plate.

Materials and Methods:
We evaluated 15 individuals who had mandibular condylar fractures. Under general anesthesia, the chosen patients underwent open reduction and fixation using three-dimensional titanium miniplates called trapezoidal condylar plates (TCPs). The Mini Retro Mandibular Approach and the Trans Masseteric Antero Parotid Approach were used to treat each of these fractures.

Results and Conclusion:
The three-dimensional Trapezoidal Condylar Plate titanium miniplates were found to be an efficient osteosynthesis device for stabilising condylar fracture and hence, yielded acceptable results in terms of achieving anatomical and functional stability.
A Retrospective Analysis of the Influence of Crown-to-Implant Ratio on Marginal Bone Loss
Authors: Alhussainan Nawaf S. , AlMugeiren Osamah M. 
Published: December 2024

ABSTRACT

Background:
For better exploration about peri-implant bone loss, understanding the crown-to-implant (C/I) ratio is essential. The present work aims to establish site-related variables which influence relationship between the C/I ratio and peri-implant marginal bone loss (MBL) as well as the effect of C/I ratio on variation in MBL surrounding the implant.

Materials and Methods:
A cohort of 30 patients, either single or multiple, with a total of 50 implants underwent examination to ascertain change in MBL and the C/I ratio. Periapical and bite-wing radiographs were obtained utilizing a bisecting angle technique. Each radiograph underwent computer-assisted calibration by evaluating previously established measurements (e.g., fixture length). The software employed for the measurement was SIDEXIS XG version 2.63. Descriptive and inferential statistics were employed.

Results:
With a mean MBL of 0.25 mm, a follow-up MBL of 1.14 mm, and an actual MBL of 0.84 mm, the average C/I ratio was determined as 0.84. A statistically significant difference (P < 0.001) was found between baseline and follow-up MBL using paired sample t-test. Additionally, C/I ratio and real MBL showed insignificant positive correlation, according to Pearson’s correlation analysis.

Conclusion:
The crown–root ratio does not have a significant impact on the actual MBL around the implant.
Elevating Expectations: Vericiguat in Heart Failure with Reduced Ejection Fraction
Authors: Patel Pushpraj , Mishra Anjeney , Gawande Sachin Madhavrao , Patel Akhilesh , Varshney Amit 
Published: December 2024

ABSTRACT

Introduction:
Heart failure (HF) with reduced ejection fraction (EF) poses high morbidity and mortality. Guidelines Directed Medical Therapy (GDMT) is essential, yet many patients experience significant symptoms. Vericiguat, a soluble guanylate cyclase stimulator, may serve as an adjunctive therapy by enhancing the nitric oxide (NO)-sGC-cyclic guanosine monophosphate (cGMP) pathway.

Methods:
This observational cohort study involved 100 participants with stage C HF and reduced EF (<40%), divided into two groups: 48 receiving vericiguat plus GDMT and 52 receiving GDMT alone. Primary outcomes included mortality, HF admissions, and changes in EF over 6 months.

Results:
Mortality rates were lower in the vericiguat group (10.4%) than in GDMT alone (17.3%, P = 0.32). HF admissions were reduced in the vericiguat group (25.0% vs 38.5%, P < 0.14), with significantly fewer mean HF admissions per patient (0.7 vs 1.2, P = 0.03). EF improved significantly more with vericiguat (+5.1% vs +2.3%, P < 0.01).

Conclusion:
Vericiguat may enhance management of stage C HF patients with reduced EF. Larger randomized controlled trials are needed to confirm these findings.
Assessment of Clinical MRI and Intraoperative Findings in Cases of Anorectal Fistula
Authors: Narsingh Narendra P. , Goswami Varun , Sharma Ranjana 
Published: December 2024

ABSTRACT

Background:
This study aimed to assess the correlation between preoperative magnetic resonance imaging (MRI) findings and intraoperative observations in patients diagnosed with anorectal fistulas and evaluate the diagnostic accuracy of MRI in identifying fistulous tracts, internal openings, and associated complications.

Materials and Methods:
A prospective study was conducted at Pt. JNM Medical College, Raipur, from April 2018 to September 2019, involving 30 patients diagnosed with anorectal fistulas. Preoperative MRI scans were performed for all patients, and findings were compared with intraoperative observations. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of MRI in detecting internal openings, fistulous tracts, and abscesses were calculated.

Results:
Among the 30 patients, 26 were male (86.66%) and 4 were female (13.33%), with a mean age of 35.6 years. MRI identified 63.33% of cases as simple fistulas and 36.66% as complex fistulas. The internal opening was most commonly located at the 6 o’clock position (26.66%). MRI findings correlated with intraoperative findings in 86.66% of cases. The sensitivity of MRI was 100% for detecting simple tracts and 80% for detecting abscesses, with discrepancies observed in 13.33% of cases.

Conclusion:
MRI proved to be a valuable tool in the preoperative evaluation of anorectal fistulas, demonstrating high accuracy in identifying fistulous tracts and associated complications. However, in some cases, intraoperative findings differed from MRI, emphasizing the need for thorough surgical exploration.
Anti-Inflammatory Activity and Free Radical Scavenging Activity of Tridax Procumbens Leaves-Based Chitosan Gel
Authors: Nandita R. , Jeevitha M. , Gurumoorthy Kaarthikeyan , Shanmugham Rajeshkumar , Ravichandran Sudarsan , Raj Kethiswar 
Published: December 2024

ABSTRACT

Introduction:

Tridax procumbens (TP) has been used as an anticoagulant and wound healer. Known by other names as Tridax daisy or coatbuttons, TP belongs to flowering plant species of Asteraceae family. The current study is conducted to analyze the anti-inflammatory and antioxidant activity of TP leaves extract-based chitosan (TPC) gel.

Materials and Methods:
Anti-inflammatory activity of TPC gel was assessed by bovine serum albumin (BSA) denaturation assay and egg albumin (EA) denaturation assay. Free radical scavenging activity was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) assay and hydroxyl radical scavenging (H2O2) assay.

Results:
Both BSA and EA assay showed that the TPC gel (test gel) demonstrated maximum inhibition at 50 μL concentration and lowest inhibition at 10 μL similar to commercially available gel. The antioxidant activity assays revealed that both standard and the test gel exhibited high inhibitory percentage at all tested concentrations.

Conclusion:
The anti-inflammatory and antioxidant assay results demonstrate that the investigated compounds, notably TP leaves extract-based chitosan gel, have the potential to be effective agents in moderating oxidative stress and lowering inflammation.
Comparative Evaluation of Tacrolimus 0.1% in Orabase and Triamcinolone Acetonide 0.1% in the Management of Recurrent Apthous Stomatitis (RAS) – A Case Control Study
Authors: Manukonda Deepthi Chandrika , Yellarthi Pavan Kumar , Pakki Suresh Kumar , Bhushan N V V Satya , Radha G. V. , Chintada Venkata Ramani 
Published: December 2024

ABSTRACT

Background:
Recurrent apthous stomatitis (RAS) and recurrent apthous ulcers are common oral ulcers which are associated with a significant amount of pain and reduction in quality of life, where traditional mainstay of treatment is topical steroids.

Methodology:
A case control study was undertaken on 90 patients seeking treatment for minor RAS and was divided into three groups. An index ulcer was selected and treated with 0.1% tacrolimus, 0.1% triamcinolone acetonide, and placebo, respectively, for 1 week.

Results:
At the end of day 2, the mean percentage reduction was 44.16%, 79.82% at day 5 and 94.26% at day 7 in the tacrolimus group, which was comparatively higher than the other two groups at day 2, day 5, and day 7. Recurrence was reported in all three groups but was not statistically significant.

Conclusion:
The results of the study suggest that 0.1% tacrolimus is more effective as an immediate mode of treatment than 0.1% triamcinolone acetonide or placebo in the management of recurrent aphthous ulcers.
Comparative Assessment of Double Y-Shaped Versus Conventional Miniplates in Fixation of Mandibular Fractures
Authors: Srivastava Swastika , Balakrishnan R. 
Published: December 2024

ABSTRACT

Aims:
The study aims to enhance the patient’s quality of life by assessing and contrasting the effectiveness of traditional miniplates and double Y-shaped titanium plates in the treatment of mandibular anterior fractures.

Method:
Ten patients with anterior mandibular fractures participated in the study and were randomly divided into two groups (Group A and Group B). The arch bar was inserted once the patient was prepared, and IMF was performed as necessary. An intraoral vestibular incision was made to expose and reduce the fracture site, leaving a 5 mm gingival cuff in place. Group A received fixation using 2 mm double Y-shaped titanium plates and 2 * 8 mm titanium screws, while Group B received fixation using two conventional miniplates and 2 * 8 mm titanium screws. Metrogyl wash was administered, and closure was achieved using 3.0 Vicryl, ensuring sufficient hemostasis. After 48 hours, Dynaplast was used to stabilize the fixation, and IMF was released.

Result:
Clinical and radiographic parameters like pain scale, neurosensory dysfunction, wound problems, fracture line width, teeth related to fracture line, and healing progression were assessed at immediate postop, 3 months, and 6 months intervals. Pain was reduced similarly till 3 months where Group A did not report pain at 6 months showing significant differences. On assessing neurosensory disturbance, Group A showed superior difference (p 0.03*). Wound healing, stability of fractured segments, fracture reduction, teeth related to fracture line, and healing improvement were adequate in both groups.

Conclusion:
Our study concluded that the use of double Y-shaped titanium plate provides a promising and alternative technique over conventional in the management of anterior mandibular fractures.
The Impact of Virtual Clinic Services on Healthcare Practitioners’ Attitudes: A Case Study at Maternity and Children Hospital Makkah al Mukarramah, Saudi Arabia
Authors: Asiri Misfer A. , Jenkins Judy , George Jomin , Hayat Aalia A. , Meny Jalal H. , Al-Qurashi Hassan H. , Alsubhi Emad N. , Almalki Saad A. 
Published: December 2024

ABSTRACT

Aims and Objectives:
This study examines healthcare practitioners’ attitudes toward virtual clinic (VC) services at the Maternity and Children Hospital (MCH) in Makkah, Saudi Arabia.

Materials and Methods:
Using a modified questionnaire based on the Unified Theory of Acceptance and Use of Technology (UTAUT) 2 model, data from 212 health practitioners was analyzed. Descriptive, regression and graphical analyses were performed using R software.

Results:
A P-value of less than 0.05 was considered significant. Results indicate significant associations between factors such as performance expectancy (0.022|), perceived value (0.004), social influence (0.002), facilitating conditions (0.002), hedonic motivation (0.029), and habit influence (0.035), and healthcare practitioners’ attitudes toward virtual clinic use. The only factor that did not significantly influence attitudes was effort expectancy (0.152). More than 61.61% of the respondents expressed a positive attitude toward using virtual services.

Conclusion:
The study highlights the increasing adoption of VC services post-COVID-19 and underscores the importance of addressing challenges such as digital infrastructure and expertise gaps.
Estimation of Alpha-Amylase in Smokers with and without Leukoplakia and Oral Cancer—A Comparative Study
Authors: Basannavar Amit A. , Bhargava Ankita , Sahoo Alkananda , Dhakar Nidhi , Shetty Rahul R. , Giri Debanti 
Published: December 2024

ABSTRACT

Background:
Alpha-amylase is an enzyme found in saliva that plays a crucial role in the initial stages of digestion. Its levels can be influenced by various factors, including lifestyle habits such as smoking.

Materials and Methods:
A total of 150 male subjects were recruited for this comparative study and divided into three groups: 50 smokers without any oral lesions (group A), 50 smokers with leukoplakia (group B), and 50 smokers with oral cancer (group C). Salivary samples were collected from each participant and analyzed for alpha-amylase activity using the 2-chloro-4-nitrophenyl-β-D-maltotrioside (CNPG3) method. Data were statistically analyzed using ANOVA and post-hoc tests to compare the mean alpha-amylase levels between the groups.

Results:
The mean alpha-amylase levels were found to be 140 U/mL in group A, 180 U/mL in group B, and 220 U/mL in group C. Statistical analysis revealed a significant increase in alpha-amylase levels in smokers with leukoplakia and oral cancer compared to smokers without oral lesions (P < 0.05). Moreover, a significant difference was observed between group B and group C (P < 0.05), indicating progressively higher enzyme levels with the severity of the oral condition.

Conclusion:
The study demonstrates that salivary alpha-amylase levels are elevated in smokers with leukoplakia and oral cancer compared to those without these conditions.
Comparative Analysis of Long-term Success Rates and Patient Satisfaction among Different Implant Placement Techniques for Implant-Supported Restorations: A Prospective Clinical Trial
Authors: Mithran Akash , Parmar Vishal B. , Sheth Malav , Mansi  , Banerjee Soumalya , Raju Minu 
Published: December 2024

ABSTRACT

Objective:
This prospective clinical trial aimed to rigorously investigate and compare the long-term success rates of implant-supported restorations using various implant placement techniques, including conventional two-stage implant placement, immediate implant placement, and guided implant surgery.

Methods:
A total of 168 participants were randomly assigned to three groups. Comprehensive preoperative assessments, involving detailed medical and dental histories, thorough clinical examinations, and cone-beam computed tomography scans, were conducted. The implant placement techniques included conventional two-stage, immediate placement, and guided surgery. Primary outcomes included clinical and radiographic implant success, while secondary outcomes encompassed prosthetic success, complication rates, and patient-reported outcomes.

Results:
Baseline characteristics demonstrated no significant differences among the groups. Implant success rates at 6, 12, and 24 months were consistently high, with no statistically significant differences between conventional two-stage (96.4%, 94.0%, and 91.1%, respectively), immediate placement (94.7%, 92.1%, and 88.5%, respectively), and guided surgery (98.2%, 96.4%, and 93.8%, respectively) techniques (P > 0.05). Prosthetic complications, including crown misfit, abutment screw loosening, and esthetic issues, exhibited comparable rates across groups (P > 0.05). Patient satisfaction scores remained consistently high at 6, 12, and 24 months, with no statistically significant differences between conventional two-stage (8.2 ± 1.1, 8.5 ± 0.9, and 8.8 ± 0.8, respectively), immediate placement (8.4 ± 1.0, 8.8 ± 0.8, and 9.1 ± 0.7, respectively), and guided surgery (8.7 ± 0.9, 9.0 ± 0.7, and 9.3 ± 0.6, respectively) techniques (P > 0.05).

Conclusion:
This study provides robust evidence supporting the comparable success rates, low prosthetic complications, and high patient satisfaction associated with conventional two-stage, immediate placement, and guided surgery techniques for implant-supported restorations.
Comparative Evaluation of Salivary Ferritin Levels as a Predictor Inflammatory Biomarker Before and After Non Surgical Periodontal Therapy- An Interventional Study
Authors: Tembhurne Saurabh , Malagi Sachin K. , Abraham Dennis V. , Pandaw Kshitibhushan S. , Mahato Arundhuti , Agrawal Priyal 
Published: December 2024

ABSTRACT

Background:
Ferritin plays a crucial role in the host immune response, with elevated serum ferritin levels established in various chronic inflammation-related diseases, including periodontitis. This study aimed to evaluate the efficacy of nonsurgical periodontal treatment on salivary ferritin levels in periodontally healthy and chronic periodontitis patients.

Materials and Methods
Fifty patients were selected and divided into two groups a control group of healthy individuals and an experimental group of chronic periodontitis patients. Salivary samples were collected using the drooling method to assess ferritin levels. The experimental group underwent nonsurgical periodontal therapy, with clinical parameters [plaque index (PI), gingival index (GI), oral hygiene index-simplified (OHIS), bleeding point index (BPI), probing pocket depth (PPD), and clinical attachment level (CAL)] recorded before and one month after therapy. Salivary samples were analyzed using CLIA, and statistical analysis was performed.

Results:
The control group showed significantly lower ferritin levels compared to the periodontitis group. Post-therapy, the periodontitis group exhibited significant improvements in both clinical parameters and ferritin levels.

Conclusion:
Salivary ferritin levels effectively predict periodontal disease and the impact of periodontal therapy, demonstrating its potential as a valuable biomarker for diagnosing and monitoring periodontal health.
Effect of Trigonella Foenum – Graceum in Diabetic Albino Wistar Rats and Their Antioxidant Properties
Authors: Vishwakarma Komal , Badade Zunjarrao G. , Dhok Archana , Kushwaha Arvind , Ambad Ranjit 
Published: December 2024

ABSTRACT

Introduction:
The WHO says diabetes is an incurable disease resulting from inadequate amounts of insulin produced by the β-cells of the pancreas or insufficient insulin use by the body. Diabetes mellitus is the 16th top cause of death globally. It is a crucial and significant public health problem. It is broadly recognized that people with diabetes have a higher chance of developing several major complications, like hypertension, hyperlipidemia, and diabetic obesity. Numerous animal models have been created over time to investigate diabetes mellitus or evaluate medications that prevent it. To generate diabetes in these models, several animal species are subjected to pharmacological, surgical (pancreatectomy), and genetic alterations.

Aims and Objectives:
To study in male Albino Wistar rats the potential anti-oxidant and anti-diabetic effects of fenugreek seeds.

Materials and Methods:
Male Wistar rats were given streptozotocin to cause diabetes; the rats were subsequently treated with fenugreek seeds. SOD and catalase levels in the serum of Wistar rats were used to determine fenugreek seeds anti-oxidant qualities.

Conclusion:
Using diabetic Albino Wistar rats, the study revealed Trigonella foenum has anti-diabetic and anti-oxidant qualities.