bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Autonomous Sensory Meridian Response Activates the Parasympathetic Nervous System
Authors: Tada Kanae , Ezaki Takahiro , Kondo Hirohito M. 
Published: November 2021

Abstract
The autonomous sensory meridian response (ASMR) produces a tingling sensation with positive feelings when binaural sounds are presented through headphones. This crossmodal response is believed to be related to sensory integration, but its psychological and physiological mechanisms are largely unknown. We conducted two experiments (on thirty and forty-two participants, respectively) to measure the subjective intensity of ASMR, finger photoplethysmography (PPG), and shift in mental states during their ASMR experience. We found that the intensity of ASMR was greater when auditory and visual stimuli were presented simultaneously than when only auditory stimuli were presented. This suggests the involvement of sensory-based, bottom-up processing. Furthermore, their pulse rates decreased and PPG amplitudes increased during the ASMR experience. Self-reported measures showed that the ASMR experience shifted participant’s negative moods to neutral mental states. These results suggest that the parasympathetic nervous system is dominant during the ASMR experience.
Mitochondrial COX4-1 deficiency leads to impaired nuclear DNA damage response resulting in proliferation deficits and premature senescence
Authors: Douiev Liza , Miller Chaya , Benyamini Hadar , Abu-Libdeh Bassam , Saada Ann 
Published: November 2021

Abstract
Cytochrome- c- oxidase (COX), a multimeric protein complex, is the final electron acceptor in the mitochondrial electron transfer chain. Primary COX deficiency, caused by mutations in either mitochondrial DNA or nuclear-encoded genes, is a heterogenous group of mitochondrial diseases with a wide range of presentations ranging from fatal infantile to subtler. We previously reported a patient with primary COX deficiency due to a pathogenic variant in COX4I1 (encoding the common isoform of COX subunit 4), who presented with bone-marrow failure, genomic instability and short stature, mimicking Fanconi anemia (FA). In the present study, we demonstrated reduced proliferation and premature senescence in this patient’s fibroblasts and in COX4-1 knockdown cells. Accumulative DNA damage coincided primarily with proliferative cells, indicating replicative stress. Expression analysis implicated DNA damage response which was verified by demonstrating impaired recovery from genotoxic insult and decreased DNA repair. Interestingly, our in-vitro findings recapitulate the patient’s presentation and present status. Thus, we suggest that the premature senescence, resulting from accumulative DNA damage in COX4-1 deficiency is a protective mechanism to avoid malignant transformation in a similar manner to what was reported for FA and other “accelerated aging diseases”.
Antiskyrmions and their electrical footprint in crystalline mesoscale structures
Authors: Winter Moritz , Goncalves Francisco J. T. , Soldatov Ivan , He Yangkun , Céspedes Belén Zéuniga , Milde Peter , Lenz Kilian , Hamann Sandra , Uhlarz Marc , Vir Praveen , König Markus , Moll Philip J. W. , Schlitz Richard , Goennenwein Sebastian T. B. , Eng Lukas M. , Schaefer Rudolf , Wosnitza Joachim , Felser Claudia , Gayles Jacob , Helm Toni 
Published: November 2021

Abstract
Skyrmionics materials hold the potential for future information technologies, such as racetrack memories. Key to that advancement are skyrmionics systems that exhibit high tunability and scalability, with stored information being easy to read and write by means of all-electrical techniques. Topological magnetic excitations, such as skyrmions and antiskyrmions give rise to a characteristic topological Hall effect (THE) in electrical transport. However, an unambiguous transport signature of antiskyrmions, in both thin films and bulk samples has been challenging to date. Here we apply magnetosensitive microscopy combined with electrical transport to directly detect the emergence of antiskyrmions in crystalline microstructures of Mn1.4PtSn at room temperature. We reveal the THE of antiskyrmions and demonstrate its tunability by means of finite sizes, field orientation, and temperature. Our atomistic simulations and experimental anisotropy studies demonstrate the link between antiskyrmions and a complex magnetism that consists of competing ferro- and antiferromagnetic as well as chiral exchange interactions.
Evaluation of the feasibility of the FAST-M maternal sepsis intervention in Pakistan, a protocol
Authors: Ahmed Sheikh Irfan , Sikandar Raheel , Barolia Rubina , Khowaja Bakhtawar M.Hanif , Memon Kashif Ali , Cheshire James , Dunlop Catherine , Coomarasamy Arri , Sheikh Lumaan , Lissauer David 
Published: November 2021

Abstract
Background

Maternal sepsis is a life-threatening condition, defined by organ dysfunction caused by infection during pregnancy, childbirth and the postpartum period. It is estimated to account for between one tenth and half of all maternal deaths globally. An international stake-holder group, including the World Health Organization, developed a maternal sepsis management bundle called “FAST-M” for resource limited settings through a synthesis of evidence and international consensus. The FAST-M treatment bundle consists of five components: Fluids, Antibiotics, Source identification and control, assessment of the need to Transport or Transfer to a higher level of care and ongoing Monitoring (of the mother and neonate). This study aims to adapt the FAST-M intervention and evaluate its feasibility in Pakistan.
Methods

The proposed study is a mixed method, with a before and after design. The study will be conducted in two phases at Liaquat University of Medical and Health Sciences, Hyderabad. In the first phase, we will adapt the bundle care tools for the local context and assess in what circumstances different components of the intervention are likely to be effective, by conducting interviews and a focus group discussion (the Adaptation Phase). In the second phase, we will evaluate the feasibility of the FAST-M intervention (the Feasibility Assessment Phase).
Discussion

The utilisation of bundles can facilitate recognition and timely management of maternal sepsis. There is a need to adapt, integrate and optimise a bundled care approach in low-resource settings in Pakistan to minimise the burden of maternal morbidities and mortalities due to sepsis.
Initial Evidence of Aedes Albopictus (Diptera: Culicidae) Domiciliation in Havana City, Cuba 1995-2018.
Authors: Fernández María del Carmen Marquetti , Castillo Magaly , Peraza Iris , Milian Maricely , Molina Roberto , Leyva Maureen , Bisset Juan A. , Vanlerberghe Veerle 
Published: November 2021

Abstract
Background. Various arboviruses are transmitted to humans by mosquitoes, particularly Aedes aegypti and Aedes albopictus, two invasive and frequently sympatric species. The objective of this study was to evaluate the behavior of Ae. albopictus with regards to houses and association with other mosquitoes in Havana province. Methods. All deposits containing water in the houses and vacant lots of urban and peri urban municipalities of the province Havana were sampled during two periods: the first 1995 – 1999 and the second 2010-2018. Results. Patterns in the presence of Ae. albopictus in the study area were observed: the persistent absence of Ae. albopictus in one municipality; in two municipalities, starting from an absence in the first period to a rapid dispersion in the following period; and a sustained decrease in the dispersion of Ae. albopictus in two other municipalities. The association of Ae. albopictus with other mosquitoes smaller in the peripheral municipalities, although being the ones with the greatest presence of Ae. albopictus. However overall, we found an increase in this association when comparing the period 2010-2018 with the first period since its introduction in Havana. Inside the houses, Ae albopictus was present in 8% (2016) to 21.5% (2013) with an average of 15%, which evidences an initial domiciliation of the species.Conclusions. The results obtained in this work show an initiation of domiciliation of Ae albopictus in the urban area of Havana province. This is important to alert the National Control Program to strengthen the entomological monitoring of Ae. albopictus, and not only Ae. aegypti. The follow up of this domiciliation is important to guide control efforts, knowing its role as a vector of different arboviruses.
Membrane compartmentalization by adherens junctions creates a spatial switch for Notch signaling and function
Authors: Kwak Minsuk , Southard Kaden , Kim Woon Ryoung , Lin Annie , Kim Nam Hyeong , Gopalappa Ramu , An Minji , Lee Hyun Jung , Choi Seo Hyun , Farlow Justin , Georgakopoulos Anastasios , Robakis Nikolaos , Kang Min , Kutys Matthew , Seo Daeha , Kim Hyongbum Henry , Kim Yong Ho , Cheon Jinwoo , Gartner Zev , Jun Young-wook 
Published: November 2021

Abstract
Adherens junctions (AJs) create spatially and mechanically discrete microdomains at the interfaces of cells. Using a mechanogenetic platform that generates artificial AJs with controlled protein localization, clustering, and mechanical loading, we report that AJs also organize proteolytic hotspots for γ-secretase with a spatially-regulated substrate selectivity that is critical in the processing of Notch and other transmembrane proteins. Membrane microdomains outside of AJs exclusively organize Notch ligand-receptor engagement (LRE-µdomain) to initialize receptor activation. Conversely, membrane microdomains within AJs exclusively serve to coordinate regulated intramembrane proteolysis (RIP-µdomain). They do so by concentrating γ-secretase and primed receptors while excluding full-length Notch. AJs induce these functionally distinct microdomains by means of cholesterol-dependent γ-secretase recruitment and size-dependent protein segregation. By excluding full-length Notch from RIP-µdomains, AJs prevents inappropriate enzyme-substrate interactions and suppresses spurious Notch activation. Ligand-induced ectodomain shedding eliminates size-dependent segregation, releasing Notch to translocate into AJs for processing by γ-secretase. This mechanism directs radial differentiative expansion of ventricular zone-neural progenitor cells in vivo and more broadly regulates the proteolysis of large cell-surface receptors like amyloid precursor protein. These findings suggest an unprecedented role of AJs in creating size-selective spatial switches that choreograph γ-secretase processing of multiple transmembrane proteins regulating development, homeostasis, and disease.
To Study the Relationship between the Expression of MiR-21, MiR-155, Mir-182, and Mir-437 and Inflammatory Factors in the Cerebrospinal Fluid of Patients with Multiple Sclerosis
Authors: Karamad Vahidreza , Sogutlu Fatma , Abbasi Samane , shademan behrouz , Laghousi Delara , Nouri Mohammad , Hassanpour Mehdi , Nourazarian Alireza 
Published: November 2021

Abstract
Background: MicroRNAs (miRNAs) affect the differentiation and function of inflammatory cells. In addition, miRNAs can regulate the expression of pro-inflammatory genes in neuron cells. Therefore, the relationship between the expression of miRNAs and inflammatory markers in the cerebrospinal fluid of individuals with multiple sclerosis was investigated.Methods: RT-PCR determined the expression levels of MiR-21, MiR-155, Mir-182, and Mir-437 in CSF samples from patients with multiple sclerosis (MS) and the control group. The levels of the inflammatory cytokines IL -1β, IL -6, and TNF-α in CSF were measured by ELISA. The level of high-sensitivity C-reactive protein (hs-CRP) was measured by the quantitative turbidometric technique.Results: The expression of miRNAs and inflammatory factors were higher in the CSF of patients with MS than in the control group, and this difference was significant (P <0.05). The results of Receiver Operating Characteristics (ROC) analysis show that the area under the curve was obtained for miRNA-21 (AUC = 0.97, P <0.0001), miRNA-182 (AUC = 0.97, P <0.0001), and miRNA-155 (AUC = 0.96, P <0.0001). The highest rate of correct diagnoses of MS was associated with miRNA-155 in CSF. The relationship between inflammatory cytokines and miRNA-21, miRNA-155, and miRNA-182 was statistically significant, but there was an indirect and moderate correlation between miRNA-437 and hs-CRP, which were also statistically significant.Conclusion: Our results showed that the CSF levels of IL -1β, IL -6, TNF-α, and hs-CRP, and selected miRNAs, serve as biomarkers of central nervous system (CNS) inflammation and neurodegenerative processes in patients with MS.
Examining the impact of COVID-19 and its related lockdown on food security and job losses: A case of Kumasi, Ghana
Authors: Adusei Frank 
Published: November 2021

Abstract
The COVID-19 and partial lockdown has brought significant effects on the entire economy, especially on food security and job losses. This study was carried out in Asokwa Municipal with the objective of examining the impact of COVID-19 disease and its related lockdown on food and nutrition security and job losses. The study site form part of the cities in Ghana to experience the partial lockdown, hence it qualifies for the selection. Both primary and secondary data were used. By means of purposive sampling technique, fifty respondents were selected as sample size. The study employed a qualitative approach with a descriptive and narrative posture to the presentation, discussion and analysis of data. Open-ended questionnaire and a checklist were used for data collection through semi-structured interviews. The results revealed that, food and nutrition insecurity, job loss and income reductions are still very common, affecting participants livelihood. Disproportionally affected are households whose income comes from farming, transporters, informal labour, as well as marketers.It was concluded that food insecurity is not outside the impact of COVID-19 and its associated partial lockdown. Food and nutrition security are the global concern at present circumstances. The supply chain has been hit hardest by COVID-19, which causes food insecurity of most vulnerable segment of population which put them at risk. And also, most of the migrant, informal, seasonal farm workers were losing their jobs which may affect their demand for food. Therefore, the government should step-up the measures to control the pandemic without disturbing the food supply chain. The development and use of online marketing strategies where people can make orders of various produce and booked for purchases and or deliveries during a stated time range should be promoted.
Is there a Link between Non Melanoma Skin Cancer and Hydrochlorothiazide?
Authors: Siniscalchi Antonio , Gallelli Luca , Cione Erika , Vasta Gianfranco , Guerra Antonio , Scaramuzzino Andrea , Longo Lucia , Muraca Lucia , De Sarro Giovambattista , “G & SP” Working Group  , Leuzzi Giacomo , Gerace Antonio , Scuteri Antonio , Vasapollo Piero , Natale Vincenzo , Zampogna Stefania , Luciani Filippo 
Published: November 2021

Aims:
Here in we evaluated the association between the use of Hydrochlorothiazide
(HCTZ) and the risk of NMSC both, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).

Background:
Even though the use of HCTZ is not linked with the development of serious adverse
drug reactions, non-melanoma skin cancer (NMSC) has been reported in patients treated with the
drug in recent years, most likely due to its photosensitizing ability.

Objective:
To evaluate the statistically significant difference (P<0.05) in the development of NMSC
between HCTZ users and non-users and the correlation (P<0.05) between HCTZ use and NMSC.

Methods:
We performed a retrospective study on patients referred to general practitioners who developed
skin cancer or NMSC whether or not they were treated with antihypertensive drugs. Controls
were matched with the test by age and sex. We calculated odds ratios (ORs) for skin cancer
and NMSC associated with hydrochlorothiazide using conditional logistic regression.

Results:
We enrolled 19,320 patients in the present study, out of a total of 10,110 (52.3%) who
were treated with antihypertensive drugs. Of 10,110 patients, 3,870 were treated with HCTZ
(38.3%). During the study, we failed to report an increased risk of NMSC in HCTZ-treated vs. untreated
patients. Gender stratification revealed an OR for NMSC of 1.36 for men and 0.56 for women.
We did not find a dose-response relationship between HCTZ use and NMSC.

Conclusions:
In the present study, we failed to report an association between the use of HCTZ and
the development of NMSC.
The Sociological Perspective of Users’ Invisible Work: A Qualitative Research Framework for Studying Digital Health Innovations Integration
Authors: Trupia Dilara Vanessa , Mathieu-Fritz Alexandre , Duong Tu Anh 
Published: November 2021

Background
When new technology is integrated into a care pathway, it faces resistance due to the changes it introduces into the existing context. To understand the success or failure of digital health innovations, it is necessary to pay attention to the adjustments that users must perform to make them work, by reshaping the context and sometimes by altering the ways in which they perform activities. This adaptation work, most of which remains invisible, constitutes an important factor in the success of innovations and the ways in which they transform care practices.

Objective
This work aims to present a sociological framework for studying new health technology uses through a qualitative analysis of the different types of tasks and activities that users, both health professionals and patients, must perform to integrate these technologies and make them work in their daily routine.

Methods
This paper uses a three-part method to structure a theoretical model to study users’ invisible work. The first part of the method includes a thematic literature review, previously published by one of the coauthors, of major sociological studies conducted on digital health innovations integration into existing care organizations and practices. The second part extends this review to introduce definitions and applications of the users’ invisible work concept. The third part consists of producing a theoretical framework to study the concept according to the different contexts and practices of the users.

Results
The paper proposes four dimensions (organizational, interactional, practical, and experiential), each composed of a set of criteria that allow a comparative analysis of different users’ work according to different health technologies.

Conclusions
This framework can be applied both as an analytical tool in a research protocol and as an agenda to identify less visible adoption criteria for digital health technologies.
ANALYSIS OF TRANSITIVITY IN READING TEXT FOR SECOND GRADE STUDENTS' OF SENIOR HIGH SCHOOL
Authors: Nurhadi Maya Annisa , Eliza  , Safitri Loli 
Published: November 2021

Abstract: This research concerned transitivity in reading text for senior high school. The purposes of this research were to describe and to find out the dominant process types of transitivity occurred in the reading text. This research was descriptive qualitative. The data was obtained from reading text in English textbook entitled Pathway to English. The result of the research were six types of process that occurred in the textbook. There were material process (38%), relational process (30%), verbal process (20%), mental process (19%), behavioural process (4%), and existential process (2%). The dominant types of transitivity was material process. It means that reading passage in English textbook entitled Pathway to English contained action and physicaly. Futhermore, the benefit that can be gained from analyzing the transitivity in the text could stimulate the reading skills to comprehend the idea and information in a text that could be applied in spoken and written texts.
The Effectiveness of Contextual Research-Based Teaching Materials on Students’ Learning Independence and Concept Mastery
Authors: Lidiawati Linda , Heliawati Leny , Pursitasari Indarini Dwi 
Published: November 2021

Innovation in teaching materials used in online learning is very urgent based on students’ needs. This study aims to measure the effectiveness of contextual research-based teaching materials to improve students’ learning independence and concept mastery of acid-base solution properties. The research method is Research and Development, referring to Borg and Gall. The research subjects were 60 students and 7 science teachers who have used teaching materials based on contextual research findings. The data collection technique in this study is a test that aims to determine the concept mastery and a questionnaire to measure students’ learning independence. Based on the results of the study, it is known that the average percentage of student learning independence is 78% (Good category). Besides, an average value of 73.83 is obtained with an N-Gain of 64% (Medium category). The use of contextual research-based teaching materials can increase learning independence in terms of information search and concept mastery of acid-base solution properties.
Rekrutmen, Karakteristik Individual, dan Komitmen Organisasional terhadap Kinerja Karyawan
Authors: Ramadhan Wildan Aditya , Setyowati Trias , Friskia Hia Yohana , Reskiputri Tatit Diansari 
Published: November 2021

Ketidaktercapaian target produksi yang berdampak terhadap penjualan perusahaan ini disebabkan oleh kompetensi karyawan yang masih kurang tentang pekerjaannya, karakteristik individu, dan juga komitmen organisasi yang dimiliki oleh karyawan masih rendah. Hal ini memengaruhi kinerja karyawan. Penelitian ini bertujuan untuk menganalisis rekrutmen, karakteristik individu, dan komitmen organisasional terhadap kinerja karyawan. Jenis penelitian yang digunakan dalam penelitian ini adalah explanatory research. Populasi dalam peneitian ini berjumlah 274, sedangkan teknik pengambilan sampel menggunakan proportional random sampling, sehingga sampel berjumlah 74 karyawan. Analisis data yang digunakan adalah analisis deskriptif dan analisis kuantitatif. Hasil penelitian menunjukkan p-value = 0,01 (<0,05) yang artinya positif dan signifikan. Dengan demikian rekrutmen berpengaruh positif terhadap kinerja karyawan. Nilai p-value = 0,00 (<0,05) yang artinya positif. Dengan demikian, karakteristik individual berpengaruh positif terhadap kinerja karyawan. Nilai p-value = 0,00 (<0,05) yang artinya positif, maka komitmen organisasional berpengaruh positif terhadap kinerja karyawan. Nilai F = 23,699 bernilai positif dengan p-value = 0,000 (<0,05) yang berarti signifikan. Dengan demikian rekrutmen, karakteristik individual, komitmen organisasional secara simultan (bersama-sama) berpengaruh positif terhadap kinerja karyawan. Implikasi penelitian ini diharapkan dapat menjadikan perusahaan lebih baik lagi dalam melaksanakan tujuan visi misi perusahaan.