bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Survival Effect of Chest Wall With or Without Regional Lymphatic Radiotherapy for Breast Cancer Patients With T3~4N0M0
Authors: Li Guanqiao , Yao Jia , Chen Junni , Cai Baizhen , Lin Xiangying , Chen Zetan , Chen Jiawei , Wang Han , Yang Shiping 
Published: July 2021

BackgroundPeripheral lymphatic radiotherapy in patients with pT3N0M0 and pT4N0M0 breast cancer has been a matter of considerable debate among radiation oncologists. This is the first report in a non-Caucasian population.Patients and MethodsThe study included 165 pT3N0M0 and pT4N0M0 patients. Univariate, multivariate, propensity score matching (PSM), and Kaplan-Meier analyses were conducted to evaluate the survival of patients. We also review all the literature about regional lymph nodes radiation in T3-4N0M0 patients and summarize them with tables to compare with the present study.ResultsThe median follow-up duration was 58.7 months. Multivariate analyses showed that advance T stage and grade were dependent poor prognostic factors for OS, DMFS, LRFS, and DFS between group A (chest wall radiation) and group B (chest wall and regional lymph nodes radiation). The overall survival (OS), disease-free survival (DFS), local relapse-free survival (LRFS), and distant metastasis-free survival (DMFS) rates were not significantly different between group A and group B. The 5-year OS rate was 92.3% vs 89.7% for group A and group B, respectively (P=0.819). The 5-year LRFS rate was 94.9% vs 94.3% for group A and group B, respectively (P=0.852). Fifty-four pairs of patients were selected after propensity score matching (PSM) analysis was conducted. There was also no significant difference between group A and group B in regard to the OS, DFS, LRFS, and DMFS rates after PSM. The patients included in previous studies were all Caucasians, and our study was focused on non-Caucasians. The cases of previous studies were 10 to 20 years ago, but our study has more recent cases. The radiotherapy techniques of previous studies were conventional, and the techniques used in our study were three-dimensional conformal radiotherapy (3DCRT) or intensity modulated radiotherapy (IMRT).ConclusionBoth our study and previous studies suggested that regional lymph nodes radiation cannot improve the survival rate for breast cancer patients with T3-4N0M0 in non-Caucasian population. Advance T stage and grade were the dependent poor prognostic factors for T3-4N0M0 patients.
A Novel Nomogram Based on Hepatic and Coagulation Function for Evaluating Outcomes of Intrahepatic Cholangiocarcinoma After Curative Hepatectomy: A Multi-Center Study of 653 Patients
Authors: Cai Yunshi , Zhang Bohan , Li Jiaxin , Li Hui , Liu Hailing , Xie Kunlin , Du Chengyou , Wu Hong 
Published: July 2021

Background and AimsHepatic and coagulation function are routine laboratory tests prior to curative hepatectomy. The prognostic value of gamma-glutamyl transpeptidase (GGT) to platelet ratio (GPR) and international normalized ratio (INR) in surgically treated patients with intrahepatic cholangiocarcinoma (ICC) remains unclear.MethodsICC patients received curative hepatectomy in two west China centers were included. Time-dependent ROC curves were conducted to compare established indexes with prognostic value for ICC. GPR-INR score was introduced and evaluated using the Time-dependent AUC curve and Kaplan-Meier survival analysis. A novel nomogram based on the GPR-INR score was proposed; Harrell’s C-index, calibration curve and decision curve analysis were used to assess this nomogram.ResultsA total of 653 patients were included. The areas under ROC curves of GPR and INR in OS and RFS were superior to other indexes. Patients with a high GPR-INR score (1,2) presented significantly decreased overall survival (OS) and recurrence-free survival (RFS); GPR-INR sore, along with several clinicopathological indexes were selected into the nomogram, the calibration curve for OS probability showed good coincidence between the nomogram and the actual surveillance. The C-index of the nomogram was 0.708 (derivation set) and 0.746 (validation set), which was more representative than the C-indexes of the GPR-INR score (0.597, 0.678). In decision curve analysis, the net benefits of the nomogram in derivation and validation set were higher than Barcelona Clinic Liver Cancer staging (BCLC) classification and American Joint Committee on Cancer (AJCC) TNM 8th staging system.ConclusionsThe proposed nomogram generated superior discriminative ability to established staging systems; it is profitable to applicate this nomogram in clinical practice.
The Use of Conditioning Open-Label Placebo in Opioid Dose Reduction: A Case Report and Literature Review
Authors: Estudillo-Guerra Maria A. , Mesia-Toledo Ines , Schneider Jeffrey C. , Morales-Quezada Leon 
Published: July 2021

Introduction: Adequate pain management for inpatients in rehabilitation units is essential for achieving therapeutic goals. Opioid treatments are commonly prescribed, but these are associated with numerous adverse effects, including the risk of addiction and decreased quality of life. Conditioning an open-label placebo is a promising approach to extend the analgesic effect of the opioid while reducing its overall dosage.Objectives: To describe a patient's experience in using conditioning open-label placebo (COLP) as a pharmaco-behavioral intervention to decrease opioid intake and its side effects after inpatient rehabilitation discharge, and to perform a literature review about the use of open-label placebo in pain.Methods: This case study has been extracted from a clinical trial initiated in 2018. A 61-year-old male was recruited at a tertiary rehabilitation hospital after suffering a traumatic sport-related injury and orthopedic surgery. Pain management included prescription of non-steroidal anti-inflammatory drugs (NSAIDs) and short-acting oxycodone. After trial participation, the patient requested off-label COLP treatment to help him decrease outpatient opioid utilization.Results: After COLP treatment, the patient could discontinue oxycodone intake (a reduction from 15 morphine equivalents/day) after rehabilitation discharge. Moreover, opioid side effects decreased from 46 to 9 points on the numerical opioid side-effects scale. A literature review identified five clinical trials using “honest” open-label placebo (OLP) or COLP as an experimental intervention for pain control. From these studies, two were in the area of chronic lower back pain, one in post spine surgery, one in irritable bowel syndrome, and another in spinal cord injury and polytrauma. Four studies reported positive outcomes related to pain control, while one study showed no significant differences in pain management between treatment-as-usual and the COLP group.Conclusion: The case report illustrates how a pharmaco-behavioral intervention can facilitate downward opioid titration safely after inpatient rehabilitation. It initiates a discussion about new approaches for opioid management using conditioning and the patient's expectation of pain relief.
The Composite of 3, 4-Dihydroxyl-Phenyl Lactic Acid and Notoginsenoside R1 Attenuates Myocardial Ischemia and Reperfusion Injury Through Regulating Mitochondrial Respiratory Chain
Authors: Yan Li , Pan Chun-Shui , Liu Yu-Ying , Cui Yuan-Chen , Hu Bai-He , Chang Xin , Wei Xiao-Hong , Huang Ping , Liu Jian , Fan Jing-Yu , Li Quan , Sun Kai , Yan Lu-Lu , He Ke , Han Jing-Yan 
Published: July 2021

Aim3,4-Dihydroxyl-phenyl lactic acid (DLA) and notoginsenoside R1 (R1) are known to protect ischemia and reperfusion (I/R) injury by targeting Sirtuin1/NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10/the Mitochondrial Complex I (Sirt-1/NDUFA10/Complex I) and Rho-associated kinase/adenosine triphosphate (ROCK/ATP) ATP synthase δ subunit (ATP 5D), respectively. We hypothesized that a composite of the two may exhibit a more potent effect on I/R injury. The study was designed to test this hypothesis.Materials and MethodsMale Sprague–Dawley rats underwent left anterior descending artery occlusion and reperfusion, with or without DLA, R1, or a combination of 3,4-dihydroxyl-phenyl lactic acid and notoginsenoside R1 (DR) pretreatment. Heart function, myocardial morphology, myocardial infarct, myocardial blood flow (MBF), apoptosis, vascular diameter, and red blood cell (RBC) velocity in venules were evaluated. Myeloperoxidase (MPO), malondialdehyde (MDA), and 8-oxo-deoxyguanosine (8-OHdG) were assessed. The content of ATP, adenosine diphosphate (ADP), and adenosine monophosphate (AMP), the activity of mitochondrial respiratory chain Complex I and its subunit NDUFA10, the Mitochondrial Complex V (Complex V) and its subunit ATP 5D, Sirt-1, Ras homolog gene family, member A (RhoA), ROCK-1, and phosphorylated myosin light chain (P-MLC) were evaluated. R1 binding to Sirt-1 was determined by surface plasmon resonance.ResultsDLA inhibited the expression of Sirt-1, the reduction in Complex I activity and its subunit NDUFA10 expression, the increase in MPO, MDA, and 8-OhdG, and apoptosis. R1 inhibited the increase in the expression of RhoA/ROCK-1/P-MLC, the reduction of Complex V activity and its subunit ATP 5D expression, alleviated F-actin, and myocardial fiber rupture. Both DLA and R1 reduced the myocardial infarction size, increased the velocities of RBC in venules, and improved MBF and heart function impaired by I/R. DR exhibited effects similar to what was exerted, respectively, by DLA and R1 in terms of respiratory chain complexes and related signaling and outcomes, and an even more potent effect on myocardial infarct size, RBC velocity, heart function, and MBF than DLA and R1 alone.ConclusionA combination of 3,4-dihydroxyl-phenyl lactic acid and notoginsenoside R1 revealed a more potent effect on I/R injury via the additive effect of DLA and R1, which inhibited not only apoptosis caused by low expression of Sirt-1/NDUFA10/Complex I but also myocardial fiber fracture caused by RhoA/ROCK-1 activation and decreased expression of ATP/ATP 5D/Complex V.
Attitudes of Different Age Groups Toward People With Intellectual Disability During the COVID-19 Pandemic
Authors: Domagała-Zyśk Ewa 
Published: July 2021

Background: The COVID-19 pandemic has been particularly risky for people with disabilities and severe medical conditions, not only because the virus may be a direct threat to their physical health but also because of social exclusion and negating their needs and rights.Objective: This study aimed to assess the attitudes of people from different age groups towards people with intellectual disability (ID).Methods: The study included 223 people (19–85 years old) and was conducted in May 2020–January 2021. Data was collected using the Multidimensional Attitudes Scale Towards Persons With Disabilities and a self-designed Questionnaire regarding the attitudes towards people with ID during the pandemic. Data analysis was performed using SPSS 24 (ANOVA).Results: The results of the study showed that the general attitudes were only slightly supportive and differed among people of different age groups: the youngest and the oldest generation expressed the most positive attitudes while the adults (35–60 y.o.) expressed the most negative ones.Conclusions: As the pandemic is spreading rapidly with no definitive solution, awareness to create more positive attitudes towards people with ID and recognizing their needs is essential.
A Local Review on the Use of a Bio-Psycho-Social Model in School-Based Mental Health Promotion
Authors: Wong Anna , Chan Iris , Tsang Christy H. C. , Chan Anna Y. F. , Shum Angie K. Y. , Lai Eliza S. Y. , Yip Paul 
Published: July 2021

Background: Schools are a key setting for student well-being promotion. Various school-based mental health programs have been implemented worldwide, with greater emphasis placed on psychological and social aspects. The bio-psycho-social model provides a holistic and integrated view of mental health based on theory and research evidence. Given the importance of considering all three dimensions in mental health promotion, this study explored reasons for the relative neglect of this approach by studying the early phase of school well-being program development and implementation.Method: In total, 77 Hong Kong government-funded student well-being programs implemented in 2000–2009 were reviewed for the use of biological, psychological, and social interventions. Questionnaires and interviews were conducted to explore program leaders' usage and views regarding theoretical frameworks and evidence-based practice and program evaluation. Challenges encountered in the initial stage of school well-being program development and implementation were identified and analyzed.Results: Of the 77 programs reviewed, only 5 addressed all three bio-psycho-social factors of mental health. A significantly greater number of programs addressed psychological (n = 63) and social (n = 40) factors compared to those that covered biological factors of mental health (n = 13). Of 24 program implementers who responded to the online survey, 75% claimed to have studied or applied a theoretical framework yet only 41.7% considered evidence-based practices to be important. The majority of interviewed participants valued their own practical experience over theory and research evidence. Many programs lacked rigorous evaluation of clear objectives and measurable outcomes, thus the mechanisms of change and program effectiveness were uncertain. Perceived barriers to program adoption and continuation were identified.Conclusion: This study highlighted a neglect of the biological contribution to mental health in school well-being promotion initiatives, possibly due to lack of theoretical knowledge and evidence-based practice among program leaders and implementers in the early phase of school mental health promotion. The bio-psycho-social model should therefore be recommended for student well-being programs as a holistic and integrated theory of mental health underpinning program objectives, mechanisms of change, and measurable outcomes. To develop effective practices in student well-being promotion, more thorough documentation, a rigorous evaluation framework, and support for frontline educators to evaluate their practices were recommended.
A Meta-Analysis of 5-Hydroxytryptamine Receptor 1B Polymorphisms With Risk of Major Depressive Disorder and Suicidal Behavior
Authors: Yang Pingliang , Yang Mengchang , Li Peng , Cao Dejun , Gong Daoyin , Lv Jiahua , Pu Linmei , Huang Sizhou , Liang Yundan 
Published: July 2021

Purpose: Previous association studies have investigated whether genetic polymorphisms in HTR1B influenced individuals' susceptibility to major depressive disorder (MDD), anti-depressant response (ADR) and suicidal behavior. However, equivocal evidence was obtained. In this meta-analysis, we aimed to examine the association of HTR1B polymorphisms with risk of MDD, ADR and suicidal behavior.Materials and Methods: Studies evaluating the association between HTR1B polymorphisms and risk of MDD, ADR and suicidal behavior were searched in Pubmed, Ovid Medline, web of science and China National Knowledge Infrastructure databases. Summary odds ratios (ORs), 95 % confidence intervals (CIs) and p-values were calculated using a fixed or random effects model.Results: Meta-analysis findings revealed a significantly increased risk of MDD with rs6296 GC and GC/CC genotypes (GC vs. GG: OR = 1.26, 95% CI, 1.07–1.48; GC/CC vs. GG: OR = 1.22, 95% CI, 1.04–1.43, respectively). Moreover, rs6298 CT genotype was significantly associated with an increased risk of suicidal behavior (CT vs. CC: OR = 1.48, 95% CI, 1.16–1.88). However, both rs6296 and rs130058 were not significant risk factors for lethal suicidal behavior.Conclusion: This meta-analysis identified that rs6296 and rs6298 in HTR1B may be significantly related to the risk of MDD and lethality of suicide attempts, respectively. Further studies are required to assess the markers in larger cohorts.
VÍRUS GIGANTES - FAUSTOVÍRUS: REVISÃO BIBLIOGRAFICA
Authors: Karabolsak Vinicius Lodi Cordeiro , Alencar Aline Paixão de , Pelizon Ana Claudia 
Published: July 2021

RESUMO: Esta revisão de literatura busca expor as características e importância dos vírus gigantes, em especial do gênero Faustovírus no ambiente humano. Esses vírus têm sido isolados a partir de Amebas em água de esgoto e têm sido associados com alguns tipos de infecção humana, como por exemplo, uma infecção relacionada ao sistema ocular. Esse gênero faz parte de um grupo de vírus gigantes relacionados à família Asfaviridae, que são vírus de fita dupla e infectam insetos e suínos. Assim, o ciclo replicativo desse gênero de vírus merece ser melhor compreendido, uma vez que já foi relatado sua interferência no organismo humano.
Palavras-Chave: Faustovírus, Asfaviridae, DNA dupla fita, Vírus gigante.
ANÁLISE DE ÍNDICES DE MORTALIDADE POR TUBERCULOSE NO ESTADO DE PERNAMBUCO
Authors: Silva Aldair De Lima , Cardoso Fabiana Silva Cruz , De Amorim Marli Christiane Nogueira , Lopes Laryssa Grazielle Feitosa , Cavalcante Giani Maria 
Published: July 2021

Introdução: A tuberculose é uma doença infectocontagiosa, considerada como um grande problema de saúde pública no Brasil e no mundo. Objetivos: Avaliar o índice de mortalidade por tuberculose no estado de Pernambuco nos últimos dez anos. Método: Trata-se de uma pesquisa quantitativa, retrospectiva, baseada em dados secundários extraídos do Sistema de Informação de Mortalidade (SIM) dos últimos nove anos. Resultados: Observou-se que o Nordeste lidera o número de óbitos, com destaque para Pernambuco que representa o estado com maior índice de mortalidade por essa patologia. Conclusão: O estado de Pernambuco precisa avançar no que diz respeito à promoção e prevenção de agravos, são necessárias orientações claras e objetivas, sensibilização da população como responsável por sua saúde, busca ativa, diagnóstico e tratamento.
DESCRITORES: Tuberculose; Enfermagem; Doenças Infectocontagiosas.
AUGMENTED REALITY APPLICATIONS IN SMART CITIES
Authors: Маколкина М.А. , Бородин А.С. , Мутханна А.С. , Кучерявый А.Е. 
Published: July 2021

Рассмотрена концепция разработки умных городов , подразумевающая создание инновационных мегаполисов с использованием ИКТ-технологий и других средств, способствующих развитию в экономическом, социальном, природоохранном и культурном направлениях. Проведен анализ возможностей применения дополненной реальности для улучшения двух аспектов жизни в городе: медицины и искусства. Предложена система для мониторинга сохранности музейных экспонатов и отображения информации о них посетителям с помощью технологии дополненной реальности.
The article discusses the concept of developing smart cities , which implies the creation of innovative megacities using ICT technologies and other means, that promote the economic, social, environmental and cultural development of cities. An analysis of the possibilities of using augmented reality to improve medicine and art in the city has been carried out. A system for monitoring the safety of museum exhibits and the presentation of information about them is proposed.
АНАЛИЗ СОВМЕСТИМОСТИ СПУТНИКОВЫХ СЕТЕЙ IOT С УСТРОЙСТВАМИ SRD И LPWAN В ДИАПАЗОНАХ ЧАСТОТ 868/915 МГЦ
Authors: Anpilogov V.R. , Nguyen D.A. 
Published: July 2021

The methodology and results of evaluating the level of interference created by the low-orbit IoT satellite on the space-Earth line are presented. It is shown that this level is lower than the level of interference that SRD and LPWAN devices create to each other, and the protective C/I ratios correspond to regulatory and technical documents. The presented methodology allows justifying the use of IoT satellite networks in the ISM 868/915 MHz band on the basis of clause 4.4 of the Radio Regulations.
Представлены методика и результаты оценки уровня помех, создаваемых низкоорбитальным спутником интернета вещей на линии космосЗемля . Показано, что этот уровень ниже уровня помех, которые создают друг другу устройства SRD и LPWAN, а защитные отношения несущей к единичной помехе C/I соответствуют нормативно-техническим документам. Определены требования к максимально допустимому значению эквивалентной изотропно-излучаемой мощности (ЭИИМ) абонентских спутниковых радиолиний. Представленная методика позволяет обосновать применение спутниковых сетей интернета вещей в диапазоне ISM 868/915 МГц на основе п. 4.4 Регламента радиосвязи.
GOLD CODES AND MAXIMUM LENGTH CODES IN NETWORK CODING
Authors: Владимиров С.С. 
Published: July 2021

Предложен вариант применения кодов Голда и кодов максимальной длины для систем сетевого кодирования. Путем математического моделирования выполнено сравнение различных способов обработки кодовых слов на приеме и приведены результаты в виде графиков вероятностных характеристик трех способов декодирования.
A variant of the application of Gold codes and maximum length codes for network coding systems is proposed. By mathematical simulation, a comparison of different methods of codewords processing at a receiver is performed. The results are presented in the form of graphs of probabilistic characteristics of three decoding methods.
Помехоустойчивость трехэлементной адаптивнойантенной решетки в многолучевых каналахрадиосвязи ДКМВ-диапазона
Authors: Metelev S.A. , Volkova E.N. 
Published: July 2021

Using the modified Watterson model of the radio channel the spatial signal processing (SSP) features of two- and three-element adaptive antenna arrays in thenonstationary multi-path HF channels are investigated. It is shown that the addition of a third antenna element significantly enhances the SSP efficiency of the multipathHF signals in comparison with two-element SSP.
Исследованы особенности пространственной обработки сигналов (ПОС) в двух- и трехэлементных антенных решетках в нестационарных многолучевых ДКМВ каналах радиосвязи. Показано, что добавление третьего антенного элемента существенно повышает эффективность ПОС по сравнению с минимально необходимыми двумя ветвями разнесения пространственной обработки.
Isolasi Nanoselulosa Terkarboksilasi dari Limbah Kulit Pisang Ambon Lumut dengan Metode Oksidasi
Authors: Nugraha Ashari Budi , Nuruddin Ahmad , Sunendar Bambang 
Published: July 2021

In this study, banana peel from ambon lumut (Musa acuminata) was used as source for nanocellulose fibers. Carboxylated nanocellulose was isolated with oxidation method using ammonium persulfate (APS). In order to investigate the effect of temperature towards the characteristics of nonocellulose, temperature for oxidation process was set at three different values: 60 Â°C, 70 Â°C, dan 80 Â°C. Nanostructure of cellulose was observed as a mix of fibers and whiskers from transmission electron microscopy (TEM) images. The diameter of nanocellulose is ranging from 12,1 to 25,1 nm. Data from spectrometry graphs (FTIR) confirms the existence of carboxyl functional groups in nanocellulose samples. X-ray diffraction pattern (XRD) shows that crystallinity index values increase as temperature of oxidation process increases. The highest crytallinity index value of 72,4% was obtained from nanocellulose treated with oxidation temperature of 80 Â°C. This analysis shows banana peel waste as a potential alternative source for carboxylated nanocellulose.