bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ensemble Skill Gains Obtained From the Multi‐Physics Versus Multi‐Model Approaches for Continental‐Scale Hydrological Simulations
Authors: Fei Wenli , Zheng Hui , Xu Zhongfeng , Wu Wen‐Ying , Lin Peirong , Tian Ye , Guo Mengyao , She Dunxian , Li Lingcheng , Li Kai , Yang Zong‐Liang 
Published: July 2021

AbstractMulti‐physics ensembles have emerged as a promising approach to hydrological simulations. As multi‐physics ensembles are constructed by perturbing the model physics, the ensemble members share a substantial portion of the same physics and hence are not independent of each other. It is unknown whether and to what extent this nonindependence affects the skill gain of the ensemble method, especially compared with the multi‐model ensemble approach. This study compares a multi‐physics ensemble configured from the Noah land surface model with multi‐parameterization options (Noah‐MP) with the North American Land Data Assimilation System (NLDAS) multi‐model ensemble. The two ensembles are evaluated in terms of the annual cycle and interannual anomaly at 12 River Forecast Centers over the conterminous United States. The ensemble skill gain is measured by the difference between the performance of the ensemble mean and the average of the ensemble members' performance, and the inter‐member independence is measured by error correlations. Results show that, due to the improved model physics, the Noah‐MP configurations outperform, on average, the NLDAS models, especially in the snow‐dominated areas. The Noah‐MP ensemble almost always obtains an outstanding member that performs the best among the two ensembles, reflecting its dense sampling of the feasible model physics space. However, these two performance superiorities do not lead to a superiority of the ensemble mean. The Noah‐MP ensemble has a lower ensemble skill gain, which corresponds to the lower inter‐member independence. These results highlight the importance of inter‐member independence, particularly when most hydrological ensemble methods have overlooked it.
The Long‐Term Response of Alternate Bars to the Hydrological Regime
Authors: Carlin Mattia , Redolfi Marco , Tubino Marco 
Published: July 2021

AbstractMigrating bars are large‐scale, alternate bedforms that often develop in channelized river reaches, as a consequence of an intrinsic instability of the erodible channel bed. Their behavior under steady flow conditions has been widely investigated by means of theoretical, experimental, and numerical models, which revealed that bar formation occurs when the width‐to‐depth ratio of the channel exceeds a critical threshold value. Conversely, no much information is available about the long‐term, average characteristics of alternate bars in the case of a complex flow regime, which makes the width‐to‐depth ratio highly variable in time. Starting from the state‐of‐the‐art theoretical models of bar dynamics, we propose a novel methodology to determine the long‐term bar response to the hydrological river regime and the associated “bar‐forming” discharge that, if applied steadily, would produce the same morphological response. We derive a generalized criterion to define whether bars are expected to form and to estimate the long‐term bar topography, depending on flow probability density function and channel characteristics (width, slope and sediment size). Our procedure differs from the classical methods to define formative discharge, inasmuch as it accounts for the specific and reversible response of bar topography to the different flow stages that compose the hydrological regime. Application to four different gravel bed reaches in the Alpine region shows the capability of the procedure to interpret remarkably different riverbed morphologies and to provide a reasonable prediction of the observed bar height, thus suggesting its potential to analyze long‐term morphological trajectories following hydrological alterations and river restoration projects.
Non‐Chained, Non‐Interacting, Stable Single‐Domain Magnetite Octahedra in Deep‐Sea Red Clay: A New Type of Magnetofossil?
Authors: Usui Yoichi , Yamazaki Toshitsugu 
Published: July 2021

AbstractMagnetic detection and classification of magnetofossils have been proposed as potential tools for paleoenvironmental studies. Magnetosomes in bacterial species living in different environmental conditions exhibit different grain morphologies and chain configurations, which determine their magnetic properties. Recently, abundant magnetofossils have been reported from unfossiliferous pelagic red clay. However, little is known about their geometry and magnetic properties. Here we report very low coercivity biogenic magnetite in red clay from Ocean Drilling Program (ODP) Site 777 in the northern Mariana Basin. Analyzed sediment showed non‐interacting, stable single‐domain‐like magnetic behaviors. Acquisition of isothermal remanence was decomposed into five components, and a component with mean coercivity below 10 mT accounted for around 25 % of the remanence in some samples. Based on comparisons with semi‐quantitative transmission electron microscopy observations of magnetic extracts, this component appears to be carried by octahedral grains with size and shape very similar to biogenic magnetite in red clay from other sites. Micromagnetic calculations indicated that isolated maghemite octahedra may be responsible for the observed low coercivity component. Based on these results, we conclude that the low coercivity component represents non‐chained biogenic magnetite that has been oxidized to maghemite. The crystal morphology, geological setting, and lithology do not suggest unusual environmental conditions for ODP Site 777, so the relative amount of chained versus non‐chained grains may represent subtle environmental differences. We suggest that non‐chained magnetofossils may be widespread in deep‐sea sediments. Some methods could overlook the presence of non‐chained magnetite, affecting the identification and quantification of magnetofossils.
Tumour-derived exosomal lncRNA-SOX2OT promotes bone metastasis of non-small cell lung cancer by targeting the miRNA-194-5p/RAC1 signalling axis in osteoclasts
Authors: Ni Jianjiao , Zhang Xiaofei , Li Juan , Zheng Zhiqin , Zhang Junhua , Zhao Weixin , Liu Liang 
Published: July 2021

AbstractBone is a frequent metastatic site of non-small cell lung cancer (NSCLC), and bone metastasis (BoM) presents significant challenges for patient survival and quality of life. Osteolytic BoM is characterised by aberrant differentiation and malfunction of osteoclasts through modulation of the TGF-β/pTHrP/RANKL signalling pathway, but its upstream regulatory mechanism is unclear. In this study, we found that lncRNA-SOX2OT was highly accumulated in exosomes derived from the peripheral blood of NSCLC patients with BoM and that patients with higher expression of exosomal lncRNA-SOX2OT had significantly shorter overall survival. Additionally, exosomal lncRNA-SOX2OT derived from NSCLC cells promoted cell invasion and migration in vitro, as well as BoM in vivo. Mechanistically, we discovered that NSCLC cell-derived exosomal lncRNA-SOX2OT modulated osteoclast differentiation and stimulated BoM by targeting the miRNA-194-5p/RAC1 signalling axis and TGF-β/pTHrP/RANKL signalling pathway in osteoclasts. In conclusion, exosomal lncRNA-SOX2OT plays a crucial role in promoting BoM and may serve as a promising prognostic biomarker and treatment target in metastatic NSCLC.
Profiling the small non-coding RNA transcriptome of the human placenta
Authors: Martinez Victor D. , Cohn David E. , Telkar Nikita , Minatel Brenda C. , Pewarchuk Michelle E. , Marshall Erin A. , Price E. Magda , Robinson Wendy P. , Lam Wan L. 
Published: July 2021

AbstractProper functioning of the human placenta is critical for maternal and fetal health. While microRNAs (miRNAs) are known to impact placental gene expression, the effects of other small non-coding RNAs (sncRNAs) on the placental transcriptome are not well-established, and are emerging topics in the study of environmental influence on fetal development and reproductive health. Here, we assembled a cohort of 30 placental chorionic villi samples of varying gestational ages (M ± SD = 23.7 ± 11.3 weeks) to delineate the human placental sncRNA transcriptome through small RNA sequence analysis. We observed expression of 1544 sncRNAs, which include 48 miRNAs previously unannotated in humans. Additionally, 18,003 miRNA variants (isomiRs) were identified from the 654 observed miRNA species. This characterization of the term and pre-term placental sncRNA transcriptomes provides data fundamental to future investigations of their regulatory functions in the human placenta, and the baseline expression pattern needed for identifying changes in response to environmental factors, or under disease conditions.
A ‘dynamic adder model’ for cell size homeostasis in Dictyostelium cells
Authors: Tanaka Masahito , Kitanishi-Yumura Toshiko , Yumura Shigehiko 
Published: July 2021

AbstractAfter a cell divides into two daughter cells, the total cell surface area of the daughter cells should increase to the original size to maintain cell size homeostasis in a single cell cycle. Previously, three models have been proposed to explain the regulation of cell size homeostasis: sizer, timer, and adder models. Here, we precisely measured the total cell surface area of Dictyostelium cells in a whole cell cycle by using the agar-overlay method, which eliminated the influence of surface membrane reservoirs, such as microvilli and membrane wrinkles. The total cell surface area exponentially increased during interphase, slightly decreased at metaphase, and then increased by approximately 20% during cytokinesis. From the analysis of the added surface area, we concluded that the cell size was regulated by the adder or near-adder model in interphase. This adder model is not caused by a simple cell membrane addition, but is more dynamic due to the rapid cell membrane turnover. We propose a ‘dynamic adder model’ to explain cell size homeostasis in interphase.
Comparison of choroidal thickness measurements between spectral domain optical coherence tomography and swept source optical coherence tomography in children
Authors: Lee Chun On , Zhang Xiujuan , Yuan Nan , Tang Shumin , Chen Li Jia , Cheung Carol Y. , Yam Jason C. 
Published: July 2021

AbstractChoroidal thickness is associated with many ocular conditions, interchangeability among different generations of optical coherence tomography is therefore important for both research purpose and clinical application. Hence, we compared choroidal thickness measurements between spectral-domain optical coherence tomography (SD-OCT) and swept-source optical coherence tomography (SS-OCT) in healthy paediatric eyes. A total of 114 children from the population-based Hong Kong Children Eye Study with mean age of 7.38 ± 0.82 years were included. Choroidal thickness of the right eye was measured by both devices. The central foveal choroidal thickness (CFCT) measured by SD-OCT and SS-OCT was 273.24 ± 54.29 μm and 251.84 ± 47.12 μm respectively. Inter-device correlation coefficient was 0.840 (95% CI 0.616–0.918). However, choroidal thickness obtained by SD-OCT was significantly thicker than that measured by SS-OCT with a mean difference of 21.40 ± 33.13 μm (P < 0.001). Bland–Altman limit of agreement on the relative difference scale for SD-OCT/SS-OCT was 86.33 μm. Validated conversion equation for translating SD-OCT CFCT measurement into SS-OCT was SS-OCT = 35.261 + 0.810 × SD-OCT. In conclusion, intra-class correlation coefficient (ICC) shows an acceptable agreement between SD-OCT and SS-OCT, however, there was a significant inter-device difference of choroidal thickness measurements in normal children eyes. Therefore, the measurements are not interchangeable.
Enhanced laser-driven proton acceleration via improved fast electron heating in a controlled pre-plasma
Authors: Gizzi Leonida A. , Boella Elisabetta , Labate Luca , Baffigi Federica , Bilbao Pablo J. , Brandi Fernando , Cristoforetti Gabriele , Fazzi Alberto , Fulgentini Lorenzo , Giove Dario , Koester Petra , Palla Daniele , Tomassini Paolo 
Published: July 2021

AbstractThe interaction of ultraintense laser pulses with solids is largely affected by the plasma gradient at the vacuum–solid interface, which modifies the absorption and ultimately, controls the energy distribution function of heated electrons. A micrometer scale-length plasma has been predicted to yield a significant enhancement of the energy and weight of the fast electron population and to play a major role in laser-driven proton acceleration with thin foils. We report on recent experimental results on proton acceleration from laser interaction with foil targets at ultra-relativistic intensities. We show a threefold increase of the proton cut-off energy when a micrometer scale-length pre-plasma is introduced by irradiation with a low energy femtosecond pre-pulse. Our realistic numerical simulations agree with the observed gain of the proton cut-off energy and confirm the role of stochastic heating of fast electrons in the enhancement of the accelerating sheath field.
Optimal distribution of piezoelectric patches for active vibration reduction of a thick plate using singular value decomposition approach
Authors: Nadi Azin , Mahzoon Mojtaba , Azadi Yazdi Ehsan 
Published: July 2021

AbstractThis paper uses the singular value decomposition approach to find the optimal distribution of a set of piezoelectric actuators and sensors in order to suppress the vibrations of a thick plate. The dynamic model of the system is derived using Mindlin plate theory and consequently, the finite difference method is employed to divide the thick plate to a finite number of nodes with appropriate horizontal and vertical distances. To compute the control force of piezoelectric actuators, the singular value decomposition approach for the column control matrix is supposed as the fitness function of an optimization problem. Through a genetic algorithm, the optimized solution is obtained. The results of numerical simulations indicate the optimal location achieved by the proposed method outperforms the previous results in suppressing the vibrations of a thick plate.
Validation and factor analysis of the parental bonding instrument in Japanese pregnant women
Authors: Sato Maya , Okada Takashi , Morikawa Mako , Nakamura Yukako , Yamauchi Aya , Ando Masahiko , Ozaki Norio 
Published: July 2021

AbstractThe Parental Bonding Instrument (PBI) evaluates parental attitudes derived from an individual’s childhood experiences with their parents. The factor structure of the PBI differs depending on variables such as psychosocial factors including culture, race, sex, and psychological and social conditions of participants. Although previous studies of the relationships between perinatal depression and parenting experiences have used the factor structures of the PBI from the general population, it is unclear whether the same factor structures are appropriate in the highly variable perinatal period. In this study, complete responses to the PBI and the Edinburgh Postnatal Depression Scale (EPDS) were received from 932 primiparas at 25 weeks of gestation and at 1 month postpartum. An exploratory factor analysis was performed on half of the responses, and it was confirmed that the three factors were care, interference, and autonomy. Confirmatory factor analysis of the remaining half of the answers showed comprehensible fitness. Each factor showed a high degree of internal consistency, and each factor of the PBI correlated with the EPDS, indicating construct validity. The reliability and validity of the PBI in perinatal Japanese women were confirmed, and it was found that the PBI had a three-factor structure.
Blood group AB increases risk for surgical necrotizing enterocolitis and focal intestinal perforation in preterm infants with very low birth weight
Authors: Martynov I. , Göpel W. , Rausch T. K. , Härtel C. , Franke A. , Franz A. R. , Viemann D. , Thome U. H. , Lacher M. , Ackermann B. W. 
Published: July 2021

AbstractNecrotizing enterocolitis (NEC) and focal intestinal perforation (FIP) are two of the most common emergencies of the gastrointestinal tract in preterm infants with very low birth weight (VLBW, birth weight < 1500 g). Identification of risk factors among these children is crucial for earlier diagnosis and prompt intervention. In this study, we investigated a relationship between ABO blood groups and the risk for surgical NEC/FIP. We genotyped the ABO locus (rs8176746 and rs8176719) in VLBW infants enrolled in a prospective, population-based cohort study of the German Neonatal Network (GNN). Of the 10,257 VLBW infants, 441 (4.3%) had surgical NEC/FIP. In univariate analyses, the blood group AB was more prevalent in VLBW infants with surgical NEC/FIP compared to non-AB blood groups (OR 1.51, 95% CI 1.07–2.13, p = 0.017; absolute risk difference 2.01%, 95% CI 0.06–3.96%). The association between blood group AB and surgical NEC/FIP was observed in a multivariable logistic regression model (OR of 1.58, 95% CI 1.10–2.26, p = 0.013) as well. In summary, our study suggests that the risk of surgical NEC and FIP is higher in patients with blood group AB and lower in those having non-AB blood groups.
Membrane vesicles of Lacticaseibacillus rhamnosus JB-1 contain immunomodulatory lipoteichoic acid and are endocytosed by intestinal epithelial cells
Authors: Champagne-Jorgensen Kevin , Mian M. Firoz , McVey Neufeld Karen-Anne , Stanisz Andrew M. , Bienenstock John 
Published: July 2021

AbstractIntestinal bacteria have diverse and complex influence on their host. Evidence is accumulating that this may be mediated in part by bacterial extracellular membrane vesicles (MV), nanometer-sized particles important for intercellular communication. Little is known about the composition of MV from gram-positive beneficial bacteria nor how they interact with intestinal epithelial cells (IEC). Here we demonstrate that MV from Lacticaseibacillus rhamnosus JB-1 are endocytosed in a likely clathrin-dependent manner by both mouse and human IEC in vitro and by mouse IEC in vivo. We further show that JB-1 MV contain lipoteichoic acid (LTA) that activates Toll-like receptor 2 (TLR2) and induces immunoregulatory interleukin-10 expression by dendritic cells in an internalization-dependent manner. By contrast, neither LTA nor TLR2 appear to be required for JB-1 MV endocytosis by IEC. These results demonstrate a novel mechanism by which bacterial MV can influence host physiology and suggest one potential route for beneficial influence of certain bacteria and probiotics.
Management of indeterminate hepatic nodules and evaluation of factors predicting their malignant potential in patients with colorectal cancer
Authors: D’Silva Mizelle , Cho Jai Young , Han Ho-Seong , Yerlan Taupyk , Yoon Yoo-Seok , Lee Hae Won , Lee Jun Suh , Lee Boram , Kim Moonhwan 
Published: July 2021

AbstractSome liver nodules remain indeterminate despite hepatocyte-specific contrast MRI in patients with colorectal liver metastasis (CRLM). Our objective was to study the natural course and evaluate possible treatment strategies for indeterminate nodules. We retrospectively evaluated patients in whom MRI revealed ‘indeterminate’ or ‘equivocal’ nodules between January 2008 and October 2018. Patients were followed up until October 2019 or until death (median, 18 months; (1–130 months)). The incidence of patients with indeterminate nodules on MRI was 15.4% (60 of 389). The sensitivity and specificity of intraoperative ultrasound for detecting indeterminate nodules were 73.68% and 93.75%, respectively, with a positive predictive value of 96.6%. Over half of the patients followed up had benign nodules (58.8%). By comparing characteristics of patients with benign or malignant nodules in the follow up group, the ratio of positive lymph nodes to total number of lymph nodes resected (pLNR) was significantly greater in patients with malignant nodules (P = 0.006). Intraoperative ultrasound could be considered as an adjunct to MRI in patients with indeterminate nodules owing to its high positive predictive value. The pLNR could be used to help select which patients can undergo conservative therapy, at least in metachronous CRLM.
A search for transiting companions in the J1407 (V1400 Cen) system
Authors: Barmentloo S. , Dik C. , Kenworthy M. A. , Mamajek E. E. , Hambsch F.-J. , Reichart D. E. , Rodriguez J. E. , van Dam D. M. 
Published: July 2021

Context. In 2007, the young star 1SWASP J140747.93-394 542.6 (V1400 Cen) underwent a complex series of deep eclipses over 56 days. This was attributed to the transit of a ring system filling a large fraction of the Hill sphere of an unseen substellar companion. Subsequent photometric monitoring has not found any other deep transits from this candidate ring system, but if there are more substellar companions and if they are coplanar with the potential ring system, there is a chance that they will transit the star as well. This young star is active, and the light curves show a 5% modulation in amplitude with a dominant rotation period of 3.2 days due to starspots rotating into and out of view.
Aims. We model and remove the rotational modulation of the J1407 light curve and search for additional transit signatures of substellar companions orbiting around J1407.
Methods. We combine the photometry of J1407 from several observatories, spanning a 19 yr baseline. We remove the rotational modulation by modeling the variability as a periodic signal, whose periodicity changes slowly with time over several years due to the activity cycle of the star. A transit least squares (TLS) analysis is used to search for any periodic transiting signals within the cleaned light curve.
Results. We identify an activity cycle of J1407 with a period of 5.4 yr. A TLS search does not find any plausible periodic eclipses in the light curve, from 1.2% amplitude at 5 days up to 1.9% at 20 days. This sensitivity is confirmed by injecting artificial transits into the light curve and determining the recovery fraction as a function of transit depth and orbital period.
Conclusions. J1407 is confirmed as a young active star with an activity cycle consistent with a rapidly rotating solar mass star. With the rotational modulation removed, the TLS analysis reaches down to planetary mass radii for young exoplanets, ruling out transiting companions with radii larger than about 1 RJup.