bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simvastatin Impairs Hippocampal Synaptic Plasticity and Cognitive Function in Mice
Authors: Guo Yujun , Zou Guichang , Qi Keke , Jin Jin , Yao Lei , Pan Yang , Xiong Wei 
Published: February 2021

Abstract
Lipophilic statins which are blood brain barrier (BBB) permeable are speculated to affect the cholesterol synthesis and neural functions in the central nervous system. However, whether these statins can affect cholesterol levels and synaptic plasticity in hippocampus and the in vivo consequence remain unclear. Here, we report that long-term subcutaneous treatments of simvastatin significantly impair mouse hippocampal synaptic plasticity, reflected by the attenuated long-term potentiation of field excitatory postsynaptic potentials. The simvastatin administration causes a deficiency in recognition and spatial memory but fails to affect motor ability and anxiety behaviors in the mice. Mass spectrometry imaging indicates a significant decrease in cholesterol intensity in hippocampus of the mice receiving chronic simvastatin treatments. Such effects of simvastatin are transient because drug discontinuation can restore the hippocampal cholesterol level and synaptic plasticity and the memory function. These findings may provide further clues to elucidate the mechanisms of neurological side effects, especially the brain cognitive
Optimisation of Microalgal Cultivation via Nutrient-Enhanced Strategies: the Biorefinery Paradigm
Authors: Figueroa-Torres Gonzalo M. , Pittman Jon , Theodoropoulos Constantinos 
Published: February 2021

Abstract
Background: The production of microalgal biofuels, despite their sustainable and renowned potential, is not yet cost-effective compared to current conventional fuel technologies. However, the biorefinery concept increases the prospects of microalgal biomass as an economically viable feedstock suitable for the co-production of multiple biofuels along with value-added chemicals. To integrate biofuels production within the framework of a microalgae biorefinery, it is not only necessary to exploit multi-product platforms, but also to identify optimal microalgal cultivation strategies maximising the microalgal metabolites from which biofuels are obtained: starch and lipids. Whilst nutrient limitation is widely known for increasing starch and lipid formation, this cultivation strategy can greatly reduce microalgal growth. This work presents an optimisation framework combining predictive modelling and experimental methodologies to effectively simulate and predict microalgal growth dynamics and identify optimal cultivation strategies. Results: Microalgal cultivation strategies for maximised starch and lipid formation were successfully established by developing a multi-parametric kinetic model suitable for the prediction of mixotrophic microalgal growth dynamics co-limited by nitrogen and phosphorus. The model’s high predictive capacity was experimentally validated against various datasets obtained from laboratory-scale cultures of Chlamydomonas reinhardtti CCAP 11/32C subject to different initial nutrient regimes. The identified model-based optimal cultivation strategies were further validated experimentally and yielded significant increases in starch (+270 %) and lipid (+74 %) production against a non-optimised strategy. Conclusions: The optimised microalgal cultivation scenarios for maximised starch and lipids, as identified by the kinetic model presented here, highlight the benefits of exploiting modelling frameworks as optimisation tools that facilitate the development and commercialisation of microalgae-to-fuel technologies.
Digitalization Development as Factor Causing Changes in Taxation Administration
Authors: Bratcev V. I. , Grishanova A. M. 
Published: February 2021

The article demonstrates the key lines in digital transformation of Russian taxation bodies aimed at ensuring the development of tax regulating methods. Managing changes in the field of digital economy requires designing and adopting regulatory decisions, which could eliminate barriers and create favorable conditions for the development of this field and cut risks connected with broad application of new technologies. In order to perform their principle functions, including those providing a high level of cash receipts to the budget system of the Russian Federation in conditions of economy digitalization tax bodies today shall develop their own digital platform, around which the ecosystem for taxpayers will be formed. The authors researched the impact of the economy digitalization process on transforming the approach to tax regulation, the focus of which is turning the system of tax bodies into the adaptive digital platform. Key indicators of the digital technology sector of the Russian Federation were studied and opportunities of the sector’s impact on tax regulation were identified. On this basis the authors showed the necessity to upgrade software products of tax bodies, which are used within the frames of tax administration. The interconnection of forms and lines of digitalization with processes of institutional changes in tax regulation was described. Among key findings of the research it is necessary to highlight substantiation of the tax system transformation under the influence of speeding-up development of digital technologies and elaboration of practical recommendations aimed at upgrading the tax administration mechanism by introducing automated multifunctional consolidating analytical tools.
The Relationship Between Individual Coping and the Need to Have and Seek Health Information Among Older Adults: Exploratory Mixed Methods Study
Authors: Theis Sabine , Schäfer Katharina , Schäfer Dajana , Jochems Nicole , Nitsch Verena , Mertens Alexander 
Published: February 2021

Background
The need to have and seek information shapes the context of computing systems. When it comes to health, individual coping influences human behavior. Therefore, the relationship between individual coping and the need to have and seek health information plays a crucial role in the development of digital health systems.

Objective
This study aims to examine the relationship between individual coping and the need to have and seek health information among older adults.

Methods
Questionnaires and semistructured interviews investigated the health information need (HIN) and health information–seeking behavior (HISB) in relation to the individual coping strategies of 26 older Germans.

Results
The mean age of the interviewed group was 71 years (SD 7). Quantitatively, a trend was found for a negative correlation between the avoidance-oriented coping and HIN (rs=−0.37895; bias-corrected and accelerated bootstrap 95% BCa CI −0.730 to 0.092; P=.05). The qualitative results supported this finding. For some participants, information and exchange was part of dealing with their health situation, whereas others wanted to learn as little as possible to avoid a decline in their health status. The older adults acquired, collected, and exchanged paper-based health data to augment clinical information sources and support information exchange with professionals.

Conclusions
Individual coping strategies are relevant for the design of digital health systems. They can support older adults in coping with their health situation, although it remains unclear how systems must be designed for people with an avoidance coping strategy to achieve the same acceptance.
Experiences of Young People and Their Caregivers of Using Technology to Manage Type 1 Diabetes Mellitus: Systematic Literature Review and Narrative Synthesis
Authors: Brew-Sam Nicola , Chhabra Madhur , Parkinson Anne , Hannan Kristal , Brown Ellen , Pedley Lachlan , Brown Karen , Wright Kristine , Pedley Elizabeth , Nolan Christopher J , Phillips Christine , Suominen Hanna , Tricoli Antonio , Desborough Jane 
Published: February 2021

Background
In the last decade, diabetes management has begun to transition to technology-based care, with young people being the focus of many technological advances. Yet, detailed insights into the experiences of young people and their caregivers of using technology to manage type 1 diabetes mellitus are lacking.

Objective
The objective of our study was to describe the breadth of experiences and perspectives on diabetes technology use among children and adolescents with type 1 diabetes mellitus and their caregivers.

Methods
This systematic literature review used integrated thematic analysis to guide a narrative synthesis of the included studies. We analyzed the perspectives and experiences of young people with type 1 diabetes mellitus and their caregivers reported in qualitative studies, quantitative descriptive studies, and studies with a mixed methods design.

Results
Seventeen articles met the inclusion criteria, and they included studies on insulin pump, glucose sensors, and remote monitoring systems. The following eight themes were derived from the analysis: (1) expectations of the technology prior to use, (2) perceived impact on sleep and overnight experiences, (3) experiences with alarms, (4) impact on independence and relationships, (5) perceived usage impact on blood glucose control, (6) device design and features, (7) financial cost, and (8) user satisfaction. While many advantages of using diabetes technology were reported, several challenges for its use were also reported, such as cost, the size and visibility of devices, and the intrusiveness of alarms, which drew attention to the fact that the user had type 1 diabetes mellitus. Continued use of diabetes technology was underpinned by its benefits outweighing its challenges, especially among younger people.

Conclusions
Diabetes technologies have improved the quality of life of many young people with type 1 diabetes mellitus and their caregivers. Future design needs to consider the impact of these technologies on relationships between young people and their caregivers, and the impact of device features and characteristics such as size, ease of use, and cost.
Combining Wearable Devices and Mobile Surveys to Study Child and Youth Development in Malawi: Implementation Study of a Multimodal Approach
Authors: Leal Neto Onicio , Haenni Simon , Phuka John , Ozella Laura , Paolotti Daniela , Cattuto Ciro , Robles Daniel , Lichand Guilherme 
Published: February 2021

Background
Multimodal approaches have been shown to be a promising way to collect data on child development at high frequency, combining different data inputs (from phone surveys to signals from noninvasive biomarkers) to understand children’s health and development outcomes more integrally from multiple perspectives.

Objective
The aim of this work was to describe an implementation study using a multimodal approach combining noninvasive biomarkers, social contact patterns, mobile surveying, and face-to-face interviews in order to validate technologies that help us better understand child development in poor countries at a high frequency.

Methods
We carried out a mixed study based on a transversal descriptive analysis and a longitudinal prospective analysis in Malawi. In each village, children were sampled to participate in weekly sessions in which data signals were collected through wearable devices (electrocardiography [ECG] hand pads and electroencephalography [EEG] headbands). Additionally, wearable proximity sensors to elicit the social network were deployed among children and their caregivers. Mobile surveys using interactive voice response calls were also used as an additional layer of data collection. An end-line face-to-face survey was conducted at the end of the study.

Results
During the implementation, 82 EEG/ECG data entry points were collected across four villages. The sampled children for EEG/ECG were 0 to 5 years old. EEG/ECG data were collected once a week. In every session, children wore the EEG headband for 5 minutes and the ECG hand pad for 3 minutes. In total, 3531 calls were sent over 5 weeks, with 2291 participants picking up the calls and 984 of those answering the consent question. In total, 585 people completed the surveys over the course of 5 weeks.

Conclusions
This study achieved its objective of demonstrating the feasibility of generating data through the unprecedented use of a multimodal approach for tracking child development in Malawi, which is one of the poorest countries in the world. Above and beyond its multiple dimensions, the dynamics of child development are complex. It is the case not only that no data stream in isolation can accurately characterize it, but also that even if combined, infrequent data might miss critical inflection points and interactions between different conditions and behaviors. In turn, combining different modes at a sufficiently high frequency allows researchers to make progress by considering contact patterns, reported symptoms and behaviors, and critical biomarkers all at once. This application showcases that even in developing countries facing multiple constraints, complementary technologies can leverage and accelerate the digitalization of health, bringing benefits to populations that lack new tools for understanding child well-being and development.
Accuracy and Monitoring of Pediatric Early Warning Score (PEWS) Scores Prior to Emergent Pediatric Intensive Care Unit (ICU) Transfer: Retrospective Analysis
Authors: Kowalski Rebecca L , Lee Laura , Spaeder Michael C , Moorman J Randall , Keim-Malpass Jessica 
Published: February 2021

Background
Current approaches to early detection of clinical deterioration in children have relied on intermittent track-and-trigger warning scores such as the Pediatric Early Warning Score (PEWS) that rely on periodic assessment and vital sign entry. There are limited data on the utility of these scores prior to events of decompensation leading to pediatric intensive care unit (PICU) transfer.

Objective
The purpose of our study was to determine the accuracy of recorded PEWS scores, assess clinical reasons for transfer, and describe the monitoring practices prior to PICU transfer involving acute decompensation.

Methods
We conducted a retrospective cohort study of patients ≤21 years of age transferred emergently from the acute care pediatric floor to the PICU due to clinical deterioration over an 8-year period. Clinical charts were abstracted to (1) determine the clinical reason for transfer, (2) quantify the frequency of physiological monitoring prior to transfer, and (3) assess the timing and accuracy of the PEWS scores 24 hours prior to transfer.

Results
During the 8-year period, 72 children and adolescents had an emergent PICU transfer due to clinical deterioration, most often due to acute respiratory distress. Only 35% (25/72) of the sample was on continuous telemetry or pulse oximetry monitoring prior to the transfer event, and 47% (34/72) had at least one incorrectly documented PEWS score in the 24 hours prior to the event, with a score underreporting the actual severity of illness.

Conclusions
This analysis provides support for the routine assessment of clinical deterioration and advocates for more research focused on the use and utility of continuous cardiorespiratory monitoring for patients at risk for emergent transfer.
Upaya Penguatan Kompetensi Kewilayahan Masyarakat Melalui Pemetaan Partisipatif pada Warga Kelurahan Lomanis, Cilacap Tengah, Cilacap
Authors: Hadibasyir Hamim Zaky , Tsani Faishol Adib , Salsabila Luluk , Akbar Hardian , Mardayanti Rosita , Pradani Grezia Eleganza Nur , Yudhiyati Ratna 
Published: February 2021

Upaya pemberdayaan masyarakat dalam rangka peningkatan kompetensi kewilayahan dilaksanakan di Kelurahan Lomanis, Kecamatan Cilacap Tengah, Kabupaten Cilacap, Jawa Tengah. Berdasarkan observasi dan wawancara dengan warga setempat, diperoleh informasi mengenai permasalahan-permasalahan yang ada. Pertama, di kantor Kelurahan Lomanis pada tahun 2013 belum terdapat peta-peta baik peta dasar maupun peta tematik yang dapat menunjang berbagai analisis kewilayahan. Kedua, sebagian warga baik para pemuda maupun anak-anak, ada yang masih belum memahami orientasi arah dan lokasi relatif kelurahan Lomanis di dalam Kabupaten Cilacap. Ketiga, beberapa data tematik seperti komposisi penduduk dan tingkat partisipasi balita dalam pos pelayanan terpadu (posyandu) belum divisualisasikan dengan peta. Oleh karena itu, kegiatan pemberdayaan ini dilakukan dalam bentuk pemetaan partisipatif untuk pengadaan peta dasar yang berupa peta administrasi dan peta tematik berupa peta komposisi penduduk dan peta tingkat partisipasi balita dalam posyandu yang nantinya dipajang di kantor kelurahan. Selain itu juga dilakukan lomba mengenal Cilacap dan Negara Kesatuan Republik Indonesia (NKRI) melalui peta guna penanaman kompetensi kewilayahan sejak dini. Semua kegiatan pemetaan partisipatif berjalan lancar. Adanya peta dasar yang memuat batas Rukun Warga (RW) dan peta-peta tematik lainnya memudahkan warga dan pemangku kepentingan lainnya dalam memahami kondisi wilayahnya. Proses pelibatan pembuatan peta secara partisipatif telah mengasah kompetensi kewilayahan warga setempat. Adapun kegiatan penguatan kompetensi kewilayahan pada anak-anak telah berjalan dengan lancar melalui kegiatan lomba mengenal Cilacap dan NKRI melalui peta. Selepas kegiatan, anak-anak di lokasi pemberdayaan semakin menyadari akan potensi dan dinamika wilayah yang ada di Kabupaten Cilacap dan Indonesia.
IMPLEMENTASI WEBSITE PROFIL SMP N 2 KARTASURA
Authors: Larasati Intan , Hajiati Sri , Hanugrah Rayyan , Anggoro Dimas Aryo 
Published: February 2021

Website merupakan media informasi yang dapat dimanfaatkan sebagai sarana memperkenalkan atau mempromosikan diri bagi suatu organisasi atau institusi. Sekolah adalah salah satu institusi yang sering menggunakan website sebagai media promosinya untuk lebih menarik calon siswa maupun masyarakat umum. SMP Negeri 2 Kartasura merupakan sebuah institusi yang berada dibawah pengawasan Dinas Pendidikan dan Kebudayaan Kabupaten Sukoharjo. Sebagai salah satu instansi pendidikan SMP Negeri 2 Kartasura mengalami kendala dalam bidang teknologi serta tenaga ahli dalam mengelola website resmi sebagai sumber informasi bagi siswa, orang tua wali, dan masyarakat umum. Sebelumnya website resmi sudah pernah dibuat oleh pihak ketiga, akan tetapi belum dipergunakan secara maksimal oleh pihak sekolah dikarenakan terkendala tenaga ahli yang kurang dan website yang dibangun masih belum tertata dengan baik, hal ini menyebabkan website tidak bisa diakses kembali. Tujuan website tersebut dibuat dipergunakan sebagai sarana media promosi yang dapat digunakan untuk memperlancar proses bertukarnya sebuah informasi yang diinginkan oleh pengunjung. Hasil dari website tersebut pengunjung dapat mengetahui secara rinci bagaimana kegiatan akademik, prestasi, dan informasi mengenai SMP Negeri 2 Kartasura. Dengan adanya website tersebut,membantu sekolah untuk memberikan informasi secara detail mengenai sekolah kepada calon murid yang ingin mendaftar ke SMP Negeri 2 Kartasura.
KATA KUNCI : Informasi, Website, SMP N 2 Kartasura
Estaciones de aprendizaje en un centro de educación especial
Authors: Signes i Monferrer Lola , Moreno Carmona Miquel 
Published: February 2021

El proyecto de aula que explicamos a continuación es el resultado del trabajo en un centro público de educación especial de la ciudad de Castelló. La experiencia se ha llevado a cabo en un aula con 8 alumnos de la etapa de secundaria, y es fruto de las inquietudes, dudas, reflexiones y debates de dos maestros convencidos de que es posible acompañar los aprendizajes de otra manera, independientemente que sea en centro ordinario o en centro específico.
La base del proyecto la encontramos en una educación respetuosa e inclusiva, aplicada a través de la organización del trabajo en estaciones de aprendizaje.
Reflexiones acerca del impacto de la crisis del coronavirus sobre las Mipymes mexicanas
Authors: Yan Li 
Published: February 2021

Desde el inicio del presente año, se ha producido el brote epidémico del coronavirus y la pandemia infecciosa se está propagando por todo el mundo. América Latina recientemente se ha convertido en el nuevo epicentro del COVID-19 tras los países asiáticos y europeos, siendo México uno de los países con mayor número de casos confirmados a nivel regional y la economía mexicana fuertemente afectada por el rápido avance de la pandemia.Este trabajo tiene como objetivo realizar un análisis de los efectos de la pandemia del coronavirus en las Mipymes en México. A pesar de ser los “motores económicos” del país, las Mipymes han sufrido consecuencias más graves de la pandemia, ya que la crisis sanitaria afectó gravemente su funcionamiento, dificultando su participación en el financiamiento del mercado, obstaculizando su producción e intercambio normal con el exterior, todo lo cual se complementa con el consecuente aumento del desempleo, la reducción de los ingresos fiscales y la disminución en el volumen comercial. Para ayudarles a resolver los problemas relevantes y paliar las enormes dificultades que enfrentan, el Gobierno mexicano ha tomado una serie de medidas emergentes como la emisión de préstamos preferenciales, las entidades financieras internacionales han prestado apoyos crediticios a pequeñas entidades. Al darse cuenta de la importancia de que goza la digitalización en los momentos más delicados, una gran mayoría de las Pymes mexicanas han llevado a cabo una “transformación digital” para adaptarse mejor a la coyuntura desfavorable.Al final del trabajo, se comenta que si bien las políticas pertinentes pueden ayudar a aliviar en cierta medida los impactos, en la era posterior a la crisis de la “nueva normalidad”, las Mipymes mexicanas deberían elaborar sus propios planes de desarrollo, fomentando continuamente las relaciones con grandes empresas, y promoviendo sólidamente la modernización de las mismas, al tener el respaldo de unas políticas públicas más inclusivas por parte del Gobierno en el futuro.
Processo de enfermagem informatizado para o cuidado a pacientes portadores de úlcera diabética: revisão integrativa da literatura
Authors: Da Mata Ciro Rodrigo Rabelo , Galvão Nariani Souza , De Menezes Sáskia Sampaio Cipriano , Hansen Lisbeth Lima , Guimarães Tracy Anne Ferreira de Oliveira , Albuquerque Aline Duarte 
Published: February 2021

Objetivo: Analisar estudos que descrevam o desenvolvimento de softwares para a informatização do Processo de Enfermagem (PE) aplicado a indivíduos portardoes de Úlcera Diabética (UD). Métodos: Revisão Integrativa da Literatura (RIL), nas bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE), Índice Bibliográfico Espanhol em Ciências da Saúde (IBECS) e Base de Dados de Enfermagem (BDENF), com publicações em português, inglês e espanhol, no período de 2015 a 2019, disponibilizados na íntegra. Resultados: Foram avaliadas 236 publicações para elegibilidade, das quais selecionou-se 5 para análise. 4 artigos utilizaram a Teoria das Necessidades Humanas Básicas como referencial teórico. Predominou-se as taxonomias North-American Nursing Diagnosis Association (NANDA-I) e Nursing Interventions Classification (NIC). Apenas 1 informatizou as 5 etapas do PE e 3 estudos utilizaramo Sistema Android. Considerações Finais: Identificou-se uma lacuna na literaturasobre o cuidado informatizado e sistematizado a essa população.Torna-se necessário o engajamento de universidades, instituições de saúde e fomento a pesquisas, no estímulo a iniciativas de ensino, pesquisa e extensãoque evidenciem a importância dainformática no apoio à tomada de decisão dos enfermeiros na assistência a indivíduos portadores de UD.