bluuebunny/crossref_metadata_2025_split huggingface dataset:
Future climate change and the distributional shift of the common vampire bat, Desmodus rotundus
Authors: Van de Vuurst Paige , Gohlke Julia M. , Escobar Luis E. 
Published: February 2025

Abstract
Interactions among humans, livestock, and wildlife within disturbed ecosystems, such as those impacted by climate change, can facilitate pathogen spillover transmission and increase disease emergence risks. The study of future climate change impacts on the distribution of free-ranging bats is therefore relevant for forecasting potential disease burden. This study used current and future climate data and historic occurrence locations of the vampire bat species Desmodus rotundus, a reservoir of the rabies virus to assess the potential impacts of climate change on disease reservoir distribution. Analyses included a comprehensive comparison of different climate change periods, carbon emission scenarios, and global circulation models (GCMs) on final model outputs. Models revealed that, although climatic scenarios and GCMs used have a significant influence on model outputs, there was a consistent signal of range expansion across the future climates analyzed. Areas suitable for D. rotundus range expansion include the southern United States and south-central portions of Argentina and Chile. Certain areas in the Amazon Rainforest, which currently rests at the geographic center of D. rotundus’ range, may become climatically unsuitable for this species within the context of niche conservatism. While the impacts of rabies virus transmitted by D. rotundus on livestock are well known, an expansion of D. rotundus into novel areas may impact new mammalian species and livestock with unexpected consequences. Some areas in the Americas may benefit from an assessment of their preparedness to deal with an expected D. rotundus range expansion.
Non-dikarya fungi share the TORC1 pathway with animals, not with Saccharomyces cerevisiae
Authors: Barua Drishtee , Płecha Magdalena , Muszewska Anna 
Published: February 2025

Abstract
Target of rapamycin (TOR), discovered in Saccharomyces cerevisiae, is a highly conserved serine/threonine kinase acting as a regulatory hub between the cell and its environment. Like mammals, in fungi, the TOR complex 1 (TORC1) pathway is essential for coordinating cell growth in response to nutrient availability. The activation of TORC1 is similar in yeast and mammals, while its inhibition is more complex in mammals. This divergence of TORC1 regulation opens the question of how common are the yeast and mammalian variants in the fungal kingdom. In this work, we trace the evolutionary history of TORC1 components throughout the fungal kingdom. Our findings show that these fungi contain the mammalian-specific KICSTOR complex for TORC1 inhibition. They also possess orthologs of serine, arginine and methionine sensors of TORC1 pathway that orchestrate the response to nutrient starvation in mammals. The Rheb-TSC mediated activation of mammalian TORC1 that was lost in Saccharomycotina was also conserved in non-Dikarya. These findings indicate that the TORC1 pathway in non-Dikarya fungi resembles mammalian TORC1. Saccharomycotina lost many of the inhibitory components and evolved alternate regulatory mechanisms. Furthermore, our work highlights the limitations of using S. cerevisiae as a fungal model while putting forward other fungi as possible research models.
HDL-ACO hybrid deep learning and ant colony optimization for ocular optical coherence tomography image classification
Authors: Agarwal Shivani , Dohare Anand Kumar , Saxena Pranshu , Singh Jagendra , Singh Indrasen , Sahu Umesh Kumar 
Published: February 2025

Abstract
Optical Coherence Tomography (OCT) plays a crucial role in diagnosing ocular diseases, yet conventional CNN-based models face limitations such as high computational overhead, noise sensitivity, and data imbalance. This paper introduces HDL-ACO, a novel Hybrid Deep Learning (HDL) framework that integrates Convolutional Neural Networks with Ant Colony Optimization (ACO) to enhance classification accuracy and computational efficiency. The proposed methodology involves pre-processing the OCT dataset using discrete wavelet transform and ACO-optimized augmentation, followed by multiscale patch embedding to generate image patches of varying sizes. The hybrid deep learning model leverages ACO-based hyperparameter optimization to enhance feature selection and training efficiency. Furthermore, a Transformer-based feature extraction module integrates content-aware embeddings, multi-head self-attention, and feedforward neural networks to improve classification performance. Experimental results demonstrate that HDL-ACO outperforms state-of-the-art models, including ResNet-50, VGG-16, and XGBoost, achieving 95% training accuracy and 93% validation accuracy. The proposed framework offers a scalable, resource-efficient solution for real-time clinical OCT image classification.
A computational framework to study the etiology of grandiose narcissism
Authors: Löschner Deborah M. , Schoemann Martin , Jauk Emanuel , Herchenhahn Lena , Schwöbel Sarah , Kanske Philipp , Scherbaum Stefan 
Published: February 2025

Abstract
Grandiose narcissism is characterized by ambivalent interaction behavior (i.e., grandiose self-presentation and rivalrous devaluation of others) and strong oscillations in self-esteem over time. In the light of emotional and social problems associated with these self-esteem regulation patterns and the increasing prevalence of narcissistic tendencies, causal and formalized models for prevention and intervention are needed. Here, we present a computational model of narcissistic self-esteem regulation implementing established, verbal theories of narcissism to identify key etiological and disorder-maintaining mechanisms. Across four studies, we show that parental praise and overvaluation lead to typical grandiose-narcissistic behavioral patterns (i.e., entitled self-presentation and rivalry) and strong self-esteem oscillations. Underlying these phenomena, we identify two maintaining mechanisms that offer targets for intervention and empirical falsification: tolerance development, characterized by an ever-increasing desire for social recognition, and a vicious cycle of rivalry, characterized by the frequent use of other-devaluing behavior and massive drops in self-esteem.
Investigation of the mechanism of chenodeoxycholic acid in treating acute lung injury through network pharmacology and experimental validation
Authors: He Chong , Jiang Mengmeng , Xiong Qian , Huang Zuoxi 
Published: February 2025

Abstract
Network pharmacology and molecular simulation techniques were employed to predict the potential targets and signaling pathways of chenodeoxycholic acid in the treatment of acute lung injury. Subsequently, its therapeutic effects on acute lung injury were preliminarily validated using animal experiments. The target of Chenodeoxycholic acid in the treatment of acute lung injury was predicted using network pharmacology. Key active ingredients and core targets were further validated using molecular docking studies. Lipopolysaccharide was used to establish a mouse model of acute lung injury to study the effect of chenodeoxycholic acid on acute lung injury. A total of 73 potential targets of Chenodeoxycholic acid for the treatment of acute lung injury were identified, primarily HSP90AA1, STAT3, HSP90AB1, EP300, and NFKB1. These core targets influence pathways associated with bile secretion, prostate cancer, and receptor activation in chemical carcinogenesis. These targets modulate various processes, including steroid metabolism, steroid biosynthesis, and intracellular receptor signaling pathways, thus contributing to the treatment of acute lung injury. Molecular docking results indicated that Chenodeoxycholic acid exhibited strong binding affinity for the core targets, with docking energies ranging from −5.6729 to −7.4138 kcal/mol. The reliability of the results was further verified by molecular dynamics simulations. Results from animal experiments demonstrated that Chenodeoxycholic acid effectively ameliorated pathological injury to lung tissue in mice with acute lung injury, decreased levels of IL-6 and TNF-α (P < 0.01), and increased levels of IL-10 (P < 0.01). The mRNA expression levels of EP300, HSP90AB1, MTOR, and STAT3 were inhibited, while the mRNA expression level of NR1H4 was significantly increased (P < 0.01). Chenodeoxycholic acid can effectively improve acute lung injury.
Development of a sustainable portable Archimedes screw turbine for hydropower generation
Authors: Khan Nouman , Sarwar Muhammad Kaleem , Rashid Muhammad , Abbasi Hafiz Kamran Jalil , Haider Saif , Tariq Muhammad Atiq Ur Rehman , Nadeem Abdullah , Zulfiqar Muhammad Ahmad , Salem Ali , Al-Ansari Nadhir , Okasha Abdelaziz M. , Dewidar Ahmed Z. , Mattar Mohamed A. 
Published: February 2025

Abstract
Portable hydropower turbines are turbines with a scale below 5 kW and which can be carried from one place to another easily by hand due to their light weight. This study was carried out to evaluate the potential of Archimedes Screw Turbine (AST) as an improved portable hydro-power turbine (PHPT) to address shortcomings in available portable turbines. The design of Archimedes screw hydro-power turbine is mainly concerned with screw geometry, which is determined by a variety of internal and external characteristics, including its length, external and internal diameter, Pitch of blades, and Number of the blades, which were 80 cm, 18 cm, 9.53 cm, 18 cm and two number of blades respectively. The turbine was manufactured from stainless steel material according to design parameters and installed in the laboratory. Experimental testing was performed at different discharges (Q) of 0.3, 0.4, 0.5, 0.6, and 0.7 ft3/s and at the angle of inclination of 22, 30, 45, and 55° of screw shaft to measure power outputs and overall efficiencies. The maximum overall efficiency obtained was 70% at a flow rate of 0.5 ft3/s and at an angle of inclination of 30°. The power output at maximum overall efficiency was 42 watts and hydraulic efficiency was 75.5%. At the flow rate of 0.3 ft3/s and an angle of inclination of 55°, the turbine produced a minimum power output of 22.8 watts and an overall efficiency of 39.4%.Experimentation revealed that the flow rate (Q) and inclination of the turbine shaft affect the turbine Power output (Po) and overall efficiency (ηo). This study helps to manufacture small AST on a large scale, to utilize small flows of water, and to evaluate the possibilities of AST as an appropriate portable hydro-power generation turbine. Further research and experimentation are needed to assess whether 3D printing can be effectively scaled for broader implementation in low-resource areas.
Making the Invisible Visible: Asian American Speech-Language Pathologists' Experiences in Their Path to the Profession
Authors: Jin Jingyu Linna , Baylor Carolyn 
Published: February 2025

Purpose:
The purpose of the study was to explore the lived experiences of Asian American speech-language pathologists (SLPs) during their graduate training.

Method:
This was a qualitative phenomenological study. Participants were 26 SLPs who self-identified as Asian American. All participants graduated from accredited master's programs in speech-language pathology in the United States and currently work clinically with adult populations. Participants attended one individual semistructured interview via videoconference to share their experiences being Asian in speech-language pathology. Thematic analysis was used to identify recurring patterns and themes from the interview data.

Results:
Three themes were derived from the participant interviews that reflect the Asian American SLPs' past experiences as graduate students and trainees. The first theme revealed the participants' motivations and affirmations for choosing the SLP career path. The second theme describes the expectations of mutual investment between the Asian American students' commitment to professional training and their training programs' support in their professional growth. The last theme talks about the social aspects of their trainee experiences that influenced their sense of belonging.

Conclusions:
There were similarities between the Asian American SLP trainee experiences and experiences of underrepresented and minoritized students from speech-language pathology and other health professions reported in the literature. Two key aspects distinct to Asian Americans and speech-language pathology were the sense of belongingness created by the social environment and the perceived tie of speech and linguistic proficiency and clinical competence. Findings contribute to how educators, leaders, and researchers can support inclusion of Asian Americans pursing speech-language pathology.
Positionspapier der Gesellschaft für Pädiatrische Gastroenterologie und Ernährung (GPGE) zum zulassungsüberschreitenden Gebrauch von für Erwachsene mit CED zugelassenen Biologika und Signalinhibitoren bei Kindern und Jugendlichen
Authors: Däbritz Jan , Classen Martin , Krohn Kathrin , Krahl Andreas , Buderus Stephan , Lainka Elke , de Laffolie Jan , Posovszky Carsten 
Published: February 2025

ZusammenfassungDie Therapie für Kinder und Jugendliche mit chronisch entzündlichen Darmerkrankungen (CED) unterscheidet sich grundsätzlich kaum von denen der erwachsenen Patienten. Derzeit sind jedoch in Deutschland von der stetig steigenden Zahl von Biologika und Signalinhibitoren für Erwachsene nur zwei TNFα-Antikörper für die Behandlung der CED ab dem vollendeten 6. Lebensjahr zugelassen. Damit stehen ein großer Teil der bei Erwachsenen mit CED zugelassenen Medikamente für moderat bis schwer erkrankte Kinder und Jugendliche nicht zur Verfügung. Die geringe Zahl zugelassener Medikamente erschwert auch das Erreichen des prognostisch wichtigen Ziels, rasch nach Diagnosestellung eine anhaltende steroidfreie Remission der CED zu erreichen, welche durch Beschwerdefreiheit des Patienten und auch dem objektivierbaren Ziel der Mukosaheilung charakterisiert ist. Dieses Positionspapier soll die aktuelle Studienlage zur medikamentösen Behandlung von Kindern und Jugendlichen mit CED außerhalb der Alterszulassung darstellen und als Grundlage für den Medizinischen Dienst bei der Begutachtung von Einzelfallanträgen sowie den behandelnden Ärztinnen und Ärzten, den Kostenträgern, gesundheitspolitischen und sozialgerichtlichen Entscheidungsträgern zur Information und Entscheidungsgrundlage dienen.
Use of Animation Video and Clay Model for Surgical Decision-Making in Patients with Early Breast Cancer—A Prospective Study
Authors: Jagannath Spandana , Sabaretnam Mayilvaganan , Mishra Shagun , Chand Gyan , Mishra Anjali , Agarwal Gaurav 
Published: February 2025

Introduction Patient perspectives on breast cancer surgical techniques are influenced by various factors. The time given by the care providers to patients for appropriate decision-making is minimal in the developing world. Effective presurgical counseling is crucial for empowering patients, managing expectations, promoting informed decision-making, and optimizing outcomes. This study employed animation storytelling technique and clay model on patients to understand breast surgical techniques.
Aims and Objectives To evaluate the use of animation video and clay model in counseling patients eligible for breast conservation surgery (BCS) on the differences between modified radical mastectomy, BCS, and oncoplasty.
Methods A prospective observational study was undertaken including 40 patients under 60 years of age, eligible for BCS, at the Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. Patients viewed a 4-minute animation video and a clay model demonstrating tissue displacement and reconstruction techniques. Responses from a three-question questionnaire were analyzed using SPSS 23 and compared with historical controls adapted from the study of Bothra et al.
Results Scores assessing awareness, understanding of surgical techniques, and interest in BCS among patients who underwent mastectomy, BCS, and oncoplasty were comparable. Patients exposed to both animation and clay models showed slightly higher scores across all groups, compared with historic controls, though not statistically significant (p = 0.144, 0.199, and 0.198). Overall, patients and relatives expressed satisfaction with the educational tools, finding them helpful in decision-making.
Conclusion Animation video and clay model are valuable tools in modern surgical education and patient care, enhancing understanding and facilitating informed decision-making. These visual aids empower patients and support health care providers in delivering comprehensive counseling on surgical options for breast cancer treatment.
Influence on electrical insulation characteristics of MAX phase Ti3AlC2 doping on polymer composite materials
Authors: Guo Kai , Wu Kai , Wang Yilong , Wang Wei , Jing Ziang , Hua Feng , Nie Weidong , Wang Xin , Zhao Peng , Kong Gang , Wu Zhenyu 
Published: February 2025

MAX phase Ti3AlC2 has excellent properties of both metal and ceramic materials, including excellent electrical and thermal conductivity, oxidation resistance, and corrosion resistance. These characteristics make MAX phase Ti3AlC2 widely used in high-temperature structural materials, wear devices, and other fields. Few studies have been conducted on the effect of electrical insulation properties in terms of typical thermosetting epoxy and phenolic or typical thermosetting polyethylene and polypropylene after doping with Ti3AlC2. In our study, we designed and synthesized a series of polymer/Ti3AlC2 functional materials with varying phr ratios, which were then preformed into 0.1–0.3 mm sheets. Accurate morphological characterization with high-resolution scanning electron microscopy, atomic force microscopy, and Kelvin probe force microscopy revealed a definite and clear influence relationship between different Ti3AlC2 phr ratios, which were subjected to functionalized groups. Furthermore, electrical characterizations such as space charge, surface discharge, and disruptive tests have revealed in-depth interactions between the MAX-phase Ti3AlC2 and polymers at specific proportions, such as 1phr for epoxy and 2.5phr for polyethylene, establish an obvious and definite influence of both the surface and interior structures of the composite materials through functional groups or agglomeration. Our results provide new insights into doping mode synthesis and property-tuning for MAX composites.
Selective adsorption mechanism of a new combined collector on the surfaces of quartz and potassium feldspar
Authors: Li Caixia , Xu Yi , Dou Mingxuan , Liu Ruize , Li Yijing , Bai Yang , Sun Qianyu , Yin Wanzhong 
Published: February 2025

This study presents a novel methodology for the separation of quartz and feldspar under neutral and weakly alkaline conditions. Ethyl-bis(dodecyl dimethyl ammonium bromide) (Gemini) is introduced as a new collector in the flotation process, combined with sodium oleate (NaOL) to enhance separation efficiency. The investigation focuses on the adsorption mechanism of these combined collectors on mineral surfaces. While the individual collectors, Gemini and NaOL, were ineffective in differentiating between quartz and feldspar, their combination resulted in significantly improved separation outcomes. Flotation tests indicated that at a pulp pH of 7, with Gemini and NaOL at concentrations of 12 × 10−5 mol l−1 and molar ratios of 1:1 and 1:2, the flotation recovery of quartz was 46.51% and 40.57% higher than that of potassium feldspar, respectively. Zeta potential measurements, Fourier transform infrared spectroscopy, x-ray photoelectron spectroscopy analyses, and molecular dynamics simulations demonstrate that the Gemini collector predominantly influences the flotation performance of quartz and feldspar. NaOL molecules do not directly adsorb onto the quartz surface; instead, they co-adsorb via electrostatic interactions with Gemini, which minimally affects the interaction dynamics. In contrast, NaOL preferentially adsorbs onto the aluminum, silicon, and other reactive sites on the feldspar surface through its –COO functional group, leading to competitive adsorption with Gemini and consequently diminishing Gemini’s effectiveness on feldspar. This study elucidates the selective separation mechanism of quartz and feldspar using Gemini and NaOL and aims to provide insights into employing combined collectors in diverse separation scenarios to enhance quartz quality.
Rapid and sensitive detection of
Fusarium oxysporum
f. sp.
cubense
tropical race 4 using a RPA-DETECTR assay
Authors: Venkatesh Jelli , Jankowicz-Cieslak Joanna , Mduma Hassan , Matijevic Mirta , Ali Adel , Balbin Isabel Cristina Calle , Soto-Suárez Mauricio , Zorrilla Cinthya , Bhatnagar-Mathur Pooja 
Published: February 2025

Abstract

Early and prompt detection of banana wilt pathogen
Fusarium oxysporum
f. sp.
cubense
(Foc), tropical race 4 (Foc TR4), causing significant banana crop losses globally is crucial to curtail the disease spread, minimize damage and implement quarantine measures. We report the first successfully developed DNA Endonuclease Targeted CRISPR Trans Reporter (DETECTR) assay with high sensitivity and specificity for detecting Foc TR4, which has been validated across several isolates. Notably, specific CRISPR RNA (crRNA) spacer sequences and recombinant polymerase amplification (RPA) primers designed and evaluated for the DETECTR assay exhibited high sensitivity, detecting Foc TR4 with genomic DNA as low as 0.005 ng, and demonstrated a very high specificity and reproducibility. The RPA-DETECTR assay was validated on a diverse panel of banana samples, including both target and non-target pathogens confirming its robustness and reliability across different types of samples, ensuring its practical applicability. In terms of throughput, the RPA-DETECTR assays enabled faster detection of Foc TR4 than other molecular diagnostics including PCR, quantitative PCR (qPCR) and droplet digital PCR (ddPCR) analyses. This makes the assay suitable for point-of-care (POC) detection of Foc TR4, and facilitating rapid decision making and immediate response. This rapid detection capability is crucial in restricting any potential transboundary movement as part of ongoing disease management efforts.
A multi-source domain adaption intelligent fault diagnosis method based on asymmetric adversarial training
Authors: Yang Dan , Ma Tianyu , Li Zhipeng 
Published: February 2025

Abstract
To enhance the cross-domain diagnostic ability of the model, domain adaptation method is adopted. When using traditional domain adaption methods to extract domain invariant characteristics of axial flow fan faults, the characteristics of the source and target domains will be close to each other, thereby the distribution of trained source domain characteristics will be changed. When the fault characteristics of the source domain gather at the classification boundary, the trained model will incorrectly classify some target samples. In addition, single source domain adaptation can lead to poor model generalization ability. To resolve the above issues, a multi-source domain adaption intelligent fault diagnosis method based on asymmetric adversarial training is proposed. In this method, the asymmetric adversarial training method is used to realize unidirectional movement of fault characteristics from the target domain to the source domain; triplet-center loss is used to expand the inter-class distance and shorten the intra-class distance of fault characteristics in the source domain; domain invariant characteristics are extracted from different source and target domains, and they are inputted to their respective fault classifiers, then aligning the outputs of each classifier using cosine similarity. To improve the cross-domain diagnostic ability of the model, a strategy of aligning weights is adopted. The industrial actual data verification results indicate that this method is effective in solving relevant practical industrial problems.