bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Common Genetic Risk Variants With Gestational Diabetes Mellitus and Their Role in GDM Prediction
Authors: Popova Polina V. , Klyushina Alexandra A. , Vasilyeva Lyudmila B. , Tkachuk Alexandra S. , Vasukova Elena A. , Anopova Anna D. , Pustozerov Evgenii A. , Gorelova Inga V. , Kravchuk Ekaterina N. , Li O. , Pervunina Tatiana M. , Kostareva Anna A. , Grineva Elena N. 
Published: April 2021

ObjectiveWe aimed to explore the associations between common genetic risk variants with gestational diabetes mellitus (GDM) risk in Russian women and to assess their utility in the identification of GDM cases.MethodsWe conducted a case-control study including 1,142 pregnant women (688 GDM cases and 454 controls) enrolled at Almazov National Medical Research Centre. The International Association of Diabetes and Pregnancy Study Groups criteria were used to diagnose GDM. A total of 11 single- nucleotide polymorphisms (SNPs), including those in HKDC1 (rs10762264), GCK (rs1799884), MTNR1B (rs10830963 and rs1387153), TCF7L2 (rs7903146 and rs12255372), KCNJ11 (rs5219), IGF2BP2 (rs4402960), IRS1 (rs1801278), FTO (rs9939609), and CDKAL1 (rs7754840) were genotyped using Taqman assays. A logistic regression model was used to calculate odds ratios (ORs) and their confidence intervals (CIs). A simple-count genetic risk score (GRS) was calculated using 6 SNPs. The area under the receiver operating characteristic curve (c-statistic) was calculated for the logistic regression model predicting the risk of GDM using clinical covariates, SNPs that had shown a significant association with GDM in our study, GRS, and their combinations.ResultsTwo variants in MTNR1B (rs1387153 and rs10830963) demonstrated a significant association with an increased risk of GDM. The association remained significant after adjustment for age, pre-gestational BMI, arterial hypertension, GDM in history, impaired glucose tolerance, polycystic ovary syndrome, family history of diabetes, and parity (P = 0.001 and P &lt; 0.001, respectively). After being conditioned by each other, the effect of rs1387153 on GDM predisposition weakened while the effect of rs10830963 remained significant (P = 0.004). The risk of GDM was predicted by clinical variables (c-statistic 0.712, 95 % CI: 0.675 – 0.749), and the accuracy of prediction was modestly improved by adding GRS to the model (0.719, 95 % CI 0.682 – 0.755), and more by adding only rs10830963 (0.729, 95 % CI 0.693 – 0.764).ConclusionAmong 11 SNPs associated with T2D and/or GDM in other populations, we confirmed significant association with GDM for two variants in MTNR1B in Russian women. However, these variants showed limited value in the identification of GDM cases.
The Effects of Sampling Lateralization on Bilateral Inferior Petrosal Sinus Sampling for Pediatric Cushing’s Disease—A Single Endocrinology Centre Experience and Review of the Literature
Authors: Moszczyńska Elzbieta , Marczak Elzbieta , Szalecki Mieczysław , Kądziołka Krzysztof , Roszkowski Marcin , Zagata-Lesnicka Patrycja 
Published: April 2021

BackgroundThis study aims to analyze the diagnostic accuracy of bilateral inferior petrosal sinus sampling (BIPSS), the gold standard test for the differential diagnosis of ACTH-dependent Cushing’s syndrome (CS) in a group of pediatric patients with Cushing’s disease (CD).MethodsThis is a retrospective analysis which include 12 patients with hypercortisolemia and inconclusive pituitary MRI, who underwent bilateral inferior petrosal sinus sampling (BIPSS) and transsphenoidal surgery (TSS) from 2004 to 2020 in the Children’s Memorial Health Institute (CMHI) Warsaw, Poland. Pituitary origin of ACTH secretion was considered if baseline central to peripheral (C/P) ACTH level ratio was ≥ 2 or C/P ratio was ≥ 3 after human corticotropin-releasing hormone (hCRH) stimulation. The diagnosis was histologically confirmed in almost all cases after TSS.ResultsThe diagnostic accuracy of BIPSS reached 75% at baseline and 83.3% after CRH stimulation. The compatibility of localization of a microadenoma by BIPSS with the surgical location was 66.7%.ConclusionsOwing to its high diagnostic effectiveness, BIPSS remains the best test to differentiate CD from EAS. The indications for the procedure should be carefully considered, because EAS in the pediatric population, unlike in adults, is extremely rare. Moreover BIPSS has only limited value for indicating tumor localization.
Glycolytic Metabolism Is Critical for the Innate Antibacterial Defense in Acute Streptococcus pneumoniae Otitis Media
Authors: Fan Fangmei , Ma Yurong , Ai Rongshuang , Ding Zhiqiang , Li Dingyi , Zhu Yiting , He Qian , Zhang Xinxin , Dong Yilin , He Yujuan 
Published: April 2021

ObjectiveStreptococcus pneumoniae (S.pn) is a common respiratory pathogen and a frequent cause of acute otitis media (AOM) in children. However, little is known about the immunometabolism during AOM. This study was to assess the presence of glucose metabolic reprogramming during AOM and its underlying mechanism affecting inflammatory response and middle ear injury.MethodsThe levels of glycolytic metabolism were evaluated by measuring the expression of glycolysis-related genes and the production of metabolites. HE stain, immunofluorescence, immunohistochemistry, enzyme-linked immunosorbent assay (ELISA) and Western blot were performed to measure the effect of glucose metabolic reprogramming on inflammatory response, pneumococcal clearance, hypoxia-inducible factor 1 alpha (HIF-1α) expression and cytokine secretion during AOM, respectively.ResultsThe analysis of microarray revealed an increase of the expression of glycolysis-related genes during S.pn–induced AOM, which was verified by real-time PCR. Increased glycolysis promoted the production of IL-1β and TNF-α and facilitated the clearance of S.pn by enhancing phagocytosis and killing capability of neutrophils, but also aggravated the middle ear injury. Furthermore, these pathogenic effects could be reversed after glycolytic inhibitor 2DG treatment. Additionally, HIF-1α was observed to involve in glycolytic metabolism during AOM.ConclusionS.pn infection induced increased glycolysis conversion during AOM, which promoted inflammatory responses and bacterial clearance, but also aggravated tissue damage.
Galectin-3 Mediated Inflammatory Response Contributes to Neurological Recovery by QiShenYiQi in Subacute Stroke Model
Authors: Wang Yule , He Shuang , Liu Xinyan , Li Zhixiong , Zhu Lin , Xiao Guangxu , Du Xiaoli , Du Hongxia , Zhang Wen , Zhang Yiqian , Orgah John , Feng Yuxin , Zhang Boli , Zhu Yan 
Published: April 2021

Effective therapies for stroke are still limited due to its complex pathological manifestations. QiShenYiQi (QSYQ), a component-based Chinese medicine capable of reducing organ injury caused by ischemia/reperfusion, may offer an alternative option for stroke treatment and post-stroke recovery. Recently, we reported a beneficial effect of QSYQ for acute stroke via modulation of the neuroinflammatory response. However, if QSYQ plays a role in subacute stroke remains unknown. The pharmacological action of QSYQ was investigated in experimental stroke rats which underwent 90 min ischemia and 8 days reperfusion in this study. Neurological and locomotive deficits, cerebral infarction, brain edema, and BBB integrity were assessed. TMT-based quantitative proteomics were performed to identify differentially expressed proteins following QSYQ treatment. Immunohistochemistry, western blot analysis, RT-qPCR, and ELISA were used to validate the proteomics data and to reveal the action mechanisms. Therapeutically, treatment with QSYQ (600 mg/kg) for 7 days significantly improved neurological recovery, attenuated infarct volume and brain edema, and alleviated BBB breakdown in the stroke rats. Bioinformatics analysis indicated that protein galectin-3 and its mediated inflammatory response was closely related to the beneficial effect of QSYQ. Specially, QSYQ (600 mg/kg) markedly downregulated the mRNA and protein expression levels of galectin-3, TNF-α, and IL-6 in CI/RI brain as well as serum levels of TNF-α and IL-6. Overall, our findings showed that the effective action of QSYQ against the subacute phase of CI/RI occurs partly via regulating galectin-3 mediated inflammatory reaction.
Effects of Nervilia fordii Extract on Pulmonary Fibrosis Through TGF-β/Smad Signaling Pathway
Authors: Yao Yufeng , Yuan Yue , Lu Zenghui , Ma Yunxia , Xie Yuanyuan , Wang Meiqi , Liu Fangle , Zhu Chenchen , Lin Chaozhan 
Published: April 2021

Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial pulmonary disease with a poor prognosis. The extract of Nervilia fordii (NFE) has shown remarkable benefit in the treatment of acute lung injury, lung cancer, and severe acute respiratory syndrome (SARS). However, the potential mechanism and efficacy of NFE in the treatment of IPF remain unknown. In this study, a systematic network pharmacology analysis was used to predict the mechanism and efficacy of NFE in the treatment of IPF, based on the major components of NFE elucidated by UPLC-TOF-MS/MS. The potential molecular interactions between the compounds and potential targets were predicted using molecular docking. In vivo, rats with pulmonary fibrosis induced by a single intratracheal injection of bleomycin (BLM) were orally administered NFE for 14 days. Lung index and biochemical levels were determined, and histopathological analysis using hematoxylin and eosin (H&amp;E) and Masson staining was performed. The effects of NFE on fibroblast proliferation in Lipopolysaccharide (LPS) and TGF-β1-induced mouse 3T6 fibroblasts were evaluated in vitro. In total, 20 components were identified in NFE, and 102 potential targets for IPF treatment were predicted. These targets potentially participate in processes regulated by transmembrane receptor protein tyrosine kinase, ERBB2, and et al. Molecular docking results predicted high affinity interactions between three components (rhamnazin, rhamnetin, and rhamnocitrin) and the potential targets, suggesting that TGF-β is the most important potential target of NFE in the treatment of pulmonary fibrosis. NFE significantly decreased the lung index and alleviated BLM-induced pulmonary fibrosis in rats. Histopathological observation of lung tissues showed that NFE alleviated inflammation and collagen deposition in BLM-induced rats. NFE inhibited the migration of LPS- and TGF-β1-induced 3T6 fibroblasts, reduced the contents of hydroxyproline and collagen, and contributed to anti-inflammation and anti-oxidation. With the intervention of NFE, the protein and RNA expression of TGF-β1, a-SMA, Smad3/4, p-Smad3/4, CTGF, and p-ERK1/2 were significantly downregulated, while Smad7 and ERK1/2 were upregulated significantly in vivo and in vitro. These findings indicated that NFE may exert therapeutic effects on pulmonary fibrosis by alleviating inflammation, oxidation, and collagen deposition. The mechanism related to the inhibition of the TGF-β/Smad signaling pathway.
PERANCANGAN LEMARI PENGERING PAKAIAN YANG ERGONOMIS DI LAUNDRY SI DOEL BATU
Authors: Sumanto Sumanto , Achmadi Sentot , Mahmudi Ali 
Published: April 2021

Sumber energi terbesar di bumi ini adalah matahari. Tidak ada kehidupan di bumi ini jika tidak ada matahari. Ketergantungan kehidupan manusia di segala bidang kehidupan terhadap matahari tidak dapat dihindari. Salah satu ketergantungan manusia terhadap energi matahari adalah proses pengeringan pakaian yang telah dicuci. Pemanfaatan sinar matahari untuk pengeringan pakaian kadang terkendala dengan musim. Ketika musim penghujan, hamper setiap hari sinar matahari terhalang awan, sehingga tidak dapat menjangkau bumi. Kondisi seperti ini kerap merugikan para pelaku usaha laundry. Untuk mengatasi hal ini dirancang sebuah alat pengering yang didesain untuk mengeringkan pakaian setelah dicuci dengan memanfaatkan panas buangan dari air conditioner (AC). Hasil rancangan berdasarkan data antropometri adalah sebuah lemari/cabinet pengering dengan dimensi tinggi 92 cm, lebar 60 cm dan panjang 55 cm. Data untuk menentukan efisiensi alat adalah menimbang massa pakaian yang telah dicuci dan dikeringkan dengan mesin cuci dan dimasukkan ke dalam lemari pengering. Selama proses pengeringan panas buangan dari AC dimasukkan ke dalam lemari pengering. Setelah selang waktu10 menit pakaian diangkat dan ditimbang massanya kemabli. Laju pengurangan air dihitung dengan selisih massa pakaian dibagi dengan selang waktu yang diperlukan. Hasil pengeringan dengan lemarin pengering dibandingkan denagn hasil pengeringan alami untuk menentukan efisiensi alat. Hasil uji coba alat menunjukkan efisiensi laju pengurangan kadar air dalam pakaian dibandingkan dengan pengeringan alami dengan cuaca mendung pakaian adalah sebagai berikut: (1) Handuk 64,15%, (2) Baju 188,10%, (3) Kaos tebal 113,56% dan (4) Kaos tipis 155,00%.
IMPROVING THE VARIOUS PROPERTIES OF THE UDA-YAGI ANTENNA
Authors: Фёдоров С.М. , Ищенко Е.А. , Зеленин И.А. , Папина Е.В. , Бунина А.В. , Сопина Л.В. 
Published: April 2021

Рассматривается антенна Уда-Яги, которая предназначена для приема сигнала наземного телевещания в 57 частотном канале. Самыми важными характеристиками для антенны Уда-Яги являются коэффициент направленного действия, передне-заднее отношение (коэффициент защитного действия), при этом данные характеристики сильно зависят от числа директоров, применяемых в конструкции антенны. На основе произведенного электродинамического моделирования было определено, как изменятся характеристики диаграмм направленности антенны на частоте 762 МГц при применении различного числа директоров - от 1 (3-элементная антенна Уда-Яги) до 12 (14-элементная антенна Уда-Яги), при этом определено оптимальное количество директоров для ситуации, когда требуется достижение максимальной помехозащищенности (максимальное значение передне-заднего отношения). Приводятся диаграммы направленности при различном числе директоров на частоте 762 МГц, графики коэффициентов защитного действия (ПЗО) от числа директоров и от частоты, таблицы со сравнительными характеристиками диаграмм направленности. Моделирование производилось с использованием метода моментов, так как при его применении достигаются высокая скорость расчетов, а также высокая точность результатов. При моделировании антенна имела один рефлектор и активный элемент в виде полуволнового диполя
The article considers the Uda-Yagi antenna, which is designed to receive a terrestrial television signal in a 57-frequency channel. The most important characteristics for an Uda-Yagi antenna are directivity, front-to-back ratio, and these characteristics are highly dependent on the number of directors used in the antenna design. On the basis of the electrodynamic simulation, we determined how the characteristics of the antenna directivity patterns at a frequency of 762 MHz will change when using a different number of directors - from 1 (3-element Uda-Yagi antenna) to 12 (14-element Uda-Yagi antenna), at the same time, we determined the optimal number of directors for the situation when the achievement of maximum noise immunity is required (the maximum value of the front-to-back ratio). The article gives directivity patterns for different numbers of directors at a frequency of 762 MHz, dependencies of directivity coefficients on the number of directors and on the frequency, tables with comparative characteristics of directivity patterns. We carried out the simulation using the method of moments, since it achieves a high speed of calculations, as well as high accuracy of results. During simulation, the antenna had one reflector and an active element in the form of a half-wave dipole
CHARACTERISTICS OF THE PSYCHOLOGICAL DOMAIN IN PATIENTS OF ADVANCED AGE WITH CONCOMITANT OPHTHALMOPATHOLOGY
Authors: Яблоков Максим Михайлович , Попова Евгения Валентиновна , Титов Антон Андреевич , Аксёнов Виталий Вячеславович , Паршин Михаил Олегович 
Published: April 2021

В современных условиях возрастная макулярная дегенерация, сочетанная с катарактой, выступает ведущей причиной потери зрения в пожилом возрасте и может способствовать развитию когнитивных и тревожно-депрессивных нарушений, которые практически не изучены для данного контингента. Цель работы: изучение когнитивных нарушений и тревожно-депрессивных расстройств у больных возрастной макулярной дегенерацией и катарактой пожилого возраста. Обследовано 125 больных 60-74 лет с возрастной макулярной дегенерацией, сочетанной с катарактой, на базе Тамбовского филиала МНТК «Микрохирургия глаза имени академика С.Н. Фёдорова». Контролем служили 74 больных аналогичного возраста без возрастной макулярной дегенерации. Были оценены тревожность - по тесту Спилбергера-Ханина, депрессивный статус по шкале Center for Epidenuologic Studies-Depression. Достоверность различий определяли по критерию U-Манна-Уитни. Установлено, что среди пациентов пожилого возраста с возрастной макулярной дегенерацией, сочетанной с катарактой, выявлены когнитивный дефицит, средний уровень личностной тревожности, значительный удельный вес со средним уровнем и повышенным уровнем личностной тревожности, расстройства депрессивного характера, а в контроле - низкий уровень тревожности и отсутствие в целом депрессивных нарушений. Возрастная макулярная дегенерация увеличивает частоту когнитивных и тревожно-депрессивных нарушений
In modern conditions, age-related macular degeneration, combined with cataracts, is the leading cause of vision loss in old age and can contribute to the development of cognitive and anxiety-depressive disorders, which are practically not studied for this population. Objective: to study cognitive impairment and anxiety-depressive disorders in elderly patients with age-related macular degeneration and cataracts. 125 patients aged 60-74 years with age-related macular degeneration combined with cataract were examined at the Tambov branch of the academician S. N. Fedorov eye microsurgery. The control group consisted of 74 patients of the same age without age-related macular degeneration. Anxiety was assessed using the spielberger-Hanin test, and depressive status was assessed using the Center for Epidemiologic Studies-Depression scale. The significance of differences was determined by the U-Mann-Whitney criterion. It was found that among elderly patients with age-related macular degeneration combined with cataracts, cognitive deficits, an average level of personal anxiety, a significant proportion with an average level and an increased level of personal anxiety, depressive disorders were detected, and in the control group - a low level of anxiety and the absence of depressive disorders in General. Age-related macular degeneration increases the frequency of cognitive and anxiety-depressive disorders
PENGARUH KAPASITAS SUMBER DAYA MANUSIA DAN PENGENDALIAN INTERN SECARA PARSIAL TERHADAP NILAI INFORMASI PELAPORAN KEUANGAN KABUPATEN/ KOTA DI PEMERINTAH PROVINSI SUMATERA SELATAN
Authors: Satria Chandra 
Published: April 2021

Penelitian ini bertujuan untuk untuk menganalisis pengaruh kapasitas sumber daya manusia dan pengendalian intern secara parsial terhadap nilai informasi pelaporan keuangan Kabupaten/ Kota di Pemerintah Provinsi Sumatera Selatan serta menganalisis pengaruh kapasitas sumber daya manusia dan pengendalian intern secara simultan terhadap nilai informasi pelaporan keuangan Kabupaten/ Kota di Pemerintah Provinsi Sumatera Selatan. Metode penelitian yang digunakan adalah analisis statistik inferensial yaitu dengan menggunakan regresi linier berganda dengan pertimbangan bahwa data yang digunakan dalam penelitian ini merupakan data primer yang bersifat kualitatif serta metode analisis agar dapat dimengerti dan dipahami dikenal secara umum. Populasi dalam penelitian ini adalah pegawai pada bagian akuntansi/penata usahaan keuangan pada SKPD Pemerintah Kota Palembang, Kabupaten Ogan Komering Ilir dan Kabupaten Musi Banyuasin. Jumlah populasi yang digunakan dalam penelitian ini sebanyak 126 orang. Instrumen yang digunakan dalam penelitian ini adalah daftar pertanyaan (kuesioner). Pertanyaan yang diajukan kepada responden menggunakan skala Likert untuk menilai sejauh mana subjek setuju atau tidak setuju dengan pertanyaan yang diajukan. Hasil Penelitian : (1) Adanya pengaruh kapasitas sumber daya manusia yang melingkupi pendidikan, pengalaman kerja, pengetahuan, keterampilan, etika, motif berprestasi dan kesempatan berprestasi terhadap nilai informasi pelaporan keuangan Kabupaten/ Kota di Pemerintah Provinsi Sumatera Selatan, (2) Adanya pengaruh pengendalian intern yang melingkupi lingkungan pengendalian, penaksiran risiko, sistem komunikasi dan informasi akuntansi, aktivitas pengendalian dan pemantauan (monitoring) (3) Terdapat pengaruh kapasitas sumberdaya manusia dan pengendalaian intern secara bersama-sama nilai informasi pelaporan keuangan Kabupaten/ Kota di Pemerintah Provinsi Sumatera Selatan. (4) Adanya variabel kapasitas sumber daya manusia memiliki pengaruh lebih dominan terhadap nilai informasi pelaporan keuangan dari pada pengendalian intern
ANALISIS TINJAUAN HUKUM ISLAM TERHADAP PEDAGANG PAKAIAN DALAM PENETAPAN HARGA DI PASAR DEMPO PERMAI KOTA PAGAR ALAM
Authors: Maryanto M. Agus , Hariani Reni , Mardalena Deva 
Published: April 2021

This research aims at asmaterial input for using the systemthe determination of the price of clothing, materials considerations for sellers in pricing according to principles of Islamic lawmaka in the current study, the researchers want to do an analysis of the review of the price of the clothes in the apply in the market based on the Islamic law Scenic Dempo in order not to violate the provisions of Sharia. In this thesis are described and analyzed pricing of clothes made by traders of clothing in the market town of Picturesque Natural Fence Dempo. The research method used is descriptive qualitative methods, i.e., explain, describe, and illustrate the situation, and then analyzed and drawn conclusions. Data collection techniques used by researchers is the observation, documentation and interviews. Based on the results of the analysis, it can be inferred that the traders of clothing in the market town of Picturesque Natural Fence Dempo method using cost-based pricing, and using principles of trade in Islam. Then the pricing practised by traders of clothing in the market town of Picturesque Natural Fence Dempo is in compliance with Islamic law, the profits obtained also according to Islamic law because the benefits of the advantage to the passing of their efforts
Escribe cien veces: “No me reiré de los profesores”. (Humor, sátira académica y novela de campus reciente en España)
Authors: García Rodríguez Javier 
Published: April 2021

A partir de la reflexión en torno a las condiciones del humor, de la risa y de la sátira, el artículo transita a través de las características de la sátira académica para desembocar en la novela de campus como subgénero narrativo. El establecimiento de los modelos de la novela de campus española de los últimos años sirve como punto de arranque para trazar los rasgos principales de la sátira académica en español, tomando como ejemplo las novelas El impostor sentimental (Xavier Moret), Carlota Fainberg (Antonio Muñoz Molina), Fresy cool (Antonio J. Rodríguez), En medio del invierno (Saúl Fernández) y El escolar brillante (Javier Rodríguez Alcaraz).
“Sobre los lomos del humor”. Polisemia, crítica y humor en la poesía última de Gloria Fuertes
Authors: Leuci Verónica 
Published: April 2021

El presente trabajo propone analizar el cruce entre poesía y humor en la poesía última de Gloria Fuertes. Nos enfocaremos en lo que denominamos “juegos polisémicos”, a través de los cuales se explotan las posibilidades dinámicas del lenguaje poético y el nombre propio de la autora. Estos juegos ponen de relieve la óptica antisolemne e irreverente que impera en los libros finales de la poeta, Historia de Gloria (1980) y Mujer de verso en pecho (1995), y que se presenta en diversos niveles complementarios, tanto temáticos como formales. Así, estos juegos formalizan una tendencia lúdica que recorre su mundo poético, a través de diversas estrategias retóricas y lingüísticas que apelan al humor como clave de lectura.