bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Lingkungan Kerja, Disiplin, dan Motivasi Kerja terhadap Kinerja Karyawan pada Dinas Pengendalian Penduduk Keluarga Berencana Pemberdayaan Perempuan dan Perlindungan Anak (DP2KB3A) Kabupaten Sumbawa Besar
Authors: Suherdiningsih Vica Fitri , Rokhman Nur 
Published: January 2025

Suatu organisasi dibentuk karena memiliki visi misi yang ingin. dicapai, sedangkan untuk mencapai tujuan organisasi tersebut tentu saja memerlukan sikap atau perilaku orang-orang yang bertanggung jawab dan memiliki kinerja yang baik. Faktor yang berpengaruh untuk mencapai hasil kerja yang baik dari karyawan adalah lingkungan kerja, motivasi dan disiplin kerja. Riset ini berusaha menjawab apakah lingkungan kerja disiplin.dan motivasi kerja berpengaruh positif dan signifikan terhadap kinerja karyawan pada DP2KBP3A Kab, Sumbawa Besar, baik secara parssial dan simultan Penelitian ini membuktikan bahwa kinerja bisa dibangun lewat variabel lingkungan kerja, motivasi dan disiplin. Hasil penelitian ini memberi manfaat bagi pemerintah dalam membangun kinerja pegawai di instansi pemerintah. Riset ini diawali dengan uji validitas dan reliabilitas kemudian uji data dengan menggunakan uji asumsi klasik dan asumsi dasar, untuk menguji pengaruh dan hipotasa menggunakan regresi liner berganda untuk melalui uji t danb uji F. Hasil riset menunjukkan bahwa variabel lingkungan kerja, motivasi dan disipin kerja berpengaruh baik secara parsial maupun simultan. Hasil riset menujukkan lingkungan kerja, motivasi dan disiplin kerja berpengaruh positif dan signifikan terhadap kinerja karyawan pada Dinas Pengendalian. Penduduk Keluarga Berencana Pemberdayaan Perempuan dan Perlindungan Anak (DP2KBP3A) Kabupaten Sumbawa Besar. Perusahaan atau Instansi Dinas Pengendalian Penduduk Keluarga Berencana Pemberdayaan Perempuan dan Perlindungan Anak (DP2KBP3A) Kab. Sumbawa Besar disarankan untuk meningkatkan kondisi lingkungan kerja, serta meningkatkan kedisiplinan dalam bekarja dan selalu memberikan motivasi terhadap karyawan sehingga karyawan dapat bekerja lebih tenang, bertanggung jawab dengan pekerjaannya dan dapat merangsang karyawan untuk lebih bergairah dalam bekerja agar kinerja karyawan dapat meningkat.
Analisis Perbandingan Kinerja Karyawan Tetap dan Karyawan Kontrak pada BPR Bank Daerah Gunungkidul
Authors: Mahaningsih Imas Panggih , Kana Any Agus 
Published: January 2025

Para manajer perbankan berupaya memenangkan persaingan dengan mengurangi biaya dan memperbaiki fleksibilitas. Tindakan strategis yang dilakukan oleh manajer guna mengurangi biaya dan meningkatkan fleksibilitas adalah mempekerjakan karyawan tetap dan karyawan kontrak. Peneliti bermaksud untuk mengetahui apakah terdapat perbedaan kinerja antara karyawan tetap dengan karyawan kontrak. Riset ini dilakukan di BPR Bank Daerah Gunungkidul. Seluruh karyawan baik berstatus tetap maupun kontrak dijadikan responden. Riset ini termasuk kategori penelitian survei. Data dikumpulkan dengan kuesioner. Uji validitas dan reliabilitas dipakai terhadap kuesioner dengan hasil semua kuesioner valid dan reliabel. Uji normalitas data dan uji homogenitas varians dilakukan untuk uji asumsi sebelum uji hipotesis. Dari hasil uji asumsi diketahui bahwa data bersifat normal dan varians bersifat homogen sehingga memenuhi asumsi yang diperlukan. Statistik parametrik dengan uji independent sample t-test dipakai untuk uji hipotesis. Program SPSSVersi25 dipakai guna membantu melakukan uji dan analisis. Hasil penelitian ini menunjukan adanya perbedaan kinerja yang signifikan antara karyawan tetap dan karyawan kontrak pada BPR Bank Daerah Gunungkidul.
Pengaruh Komunikasi Pemasaran Terpadu terhadap Ekuitas Merek: Studi pada Hotel Cakra Kembang Yogyakarta
Authors: Umami Lisiya Fatma , Transistari Ralina 
Published: January 2025

Penelitian ini bertujuan untuk mengetahui pengaruh komunikasi pemasaran terpadu terhadap ekuitas merek pada Hotel Cakra Kembang secara simultan maupun parsial. Variabel independen yang digunakan adalah iklan, promosi penjualan, penjualan personal, hubungan masyarakat, pemasaran langsung, pemasaran interaktif, dan corporate design, sedangkan variabel dependennya adalah ekuitas merek. Metode analisis yang digunakan adalah Regresi Linier Berganda. Data dikumpulkan dengan kuesioner yang dibagikan kepada 91 responden yang menginap di Hotel Cakra Kembang Yogyakarta pada bulan November 2019. Hasil penelitian menunjukkan bahwa komunikasi pemasaran terpadu yang terdiri atas iklan, promosi penjualan, penjualan personal, hubungan masyarakat, pemasaran langsung, pemasaran interaktif, dan corporate design secara simultan berpengaruh terhadap ekuitas merek pada Hotel Cakra Kembang Yogyakarta. Sedangkan secara parsial hanya pemasaran langsung dan corporate design yang berpengaruh positif terhadap ekuitas merek pada Hotel Cakra Kembang Yogyakarta.
Motivasi Belanja Hedonis, Gaya Hidup dan Keterlibatan Fashion pada Pembelian Impulsif
Authors: Sudarusman Eka 
Published: January 2025

Perilaku pembelian impulsif merupakan fenomena yang terjadi dalam kehidupan sehari-hari yang dilakukan tanpa sadar oleh mahasiswa. Penelitian ini bertujuan untuk menganalisis pengaruh hedonic shopping motivation, shopping lifestyle dan fashion involvement terhadap pembelian impulsif pada produk pakaian bagi mahasiswa di Yogyakarta. Penelitian ini dilakukan pada mahasiswa di Yogyakarta. Hal ini disebabkan Yogyakarta merupakan Kota Pelajar yang terdapat banyak intitusi pendidikan terutama universitas, sehingga dapat memenuhi tujuan penelitian. Penelitian ini dilakukanpada mahasiswa di Yogyakarta selama tiga (3) bulan, yaitu pada bulan Juni sampai bulan Agustus 2023. Populasi dalam penelitian ini adalah seluruh mahasiswa aktif di pada tahun 2022/2023. Sampelpenelitian sebanyak 125 mahasiswa aktif di Yogyakarta pada tahun 2022/2023 dengan purposive sampling sebagai teknik pengambilan sampel. Teknik pengumpulan data dilakukan dengan observasi dan kuesioner, adapun analisis data dilakukan dengan analisis regresi linear berganda. Hasil penelitian menunjukkan bahwa hedonic shopping motivation, shopping lifestyle dan fashion involvement berpengaruh signifikan terhadap pembelian impulsif pada produk pakaian bagi mahasiswa di Yogyakarta.
Diseminasi Media Program Linier Berbasis Geogebra (PROLIBRA) bagi Guru Matematika SMA Negeri 1 Karang Baru Kabupaten Aceh Tamiang
Authors: Sari Riezky Purnama , Nurviana Nurviana , Fairus Fairus 
Published: January 2025

<p>Penggunaan media pembelajaran berbasis teknologi saat ini menjadi semakin penting sebagai upaya peningkatan pemahaman siswa terhadap konsep yang diajarkan serta membuat suasana kelas lebih menarik. Namun kenyataannya sebagian besar guru matematika hanya mengandalkan buku ajar dan LKS dari sekolah tanpa membuat atau memanfaatkan media pembelajaran berbasis teknologi. Tujuan kegiatan PKM ini adalah untuk meningkatkan kemampuan guru matematika dalam memanfaatkan dan menggunakan media pembelajaran berbasis teknologi dengan memberikan pemahaman dan pelatihan Media Program Linier berbasis Geogebra (PROLIBRA). Hasil observasi awal mengidentifikasi dua permasalahan prioritas Mitra, yaitu: 1) Rendahnya Pengetahuan dan motivasi guru matematika dalam menggunakan media pembelajaran berbasis teknologi. 2) Kurang terampilnya guru matematika dalam memanfaatkan dan menggunakan media pembelajaran berbasis teknologi. Solusi yang ditawarkan adalah: Memberikan Sosialisasi untuk meningkatkan pengetahuan dan motivasi serta memberikan pelatihan pemanfaatan media PROLIBRA. Metode yang digunakan adalah ceramah, diskusi dan praktik. Hasil Kegiatan menunjukkan Guru mendapatkan pemahaman tentang pentingnya memanfaatkan media pembelajaran berbasis teknologi. Guru sudah terampil menggunakan Media PROLIBRA serta sudah mampu membuat bahan ajar dengan bantuan geogebra secara mandiri. Selain itu, 95% mitra setuju bahwa PKM ini dapat meningkatkan pengetahuan dan pemahaman mengenai pentingnya pembelajaran berbasis teknologi dalam pembelajaran matematika dan 85% setuju Mitra mengalami peningkatan keterampilan dalam pembuatan media pembelajaran PROLIBRA.<em></em></p>
VESÍCULAS EXTRACELULARES: AVALIAÇÃO DA APLICABILIDADE TERAPEUTICA NA UTILIZAÇÃO CLÍNICA DE CÉLULAS-TRONCO MULTI E PLURIPOTENTES. UMA REVISÃO INTEGRATIVA
Authors: Sousa Filho José Kilderlan Nascimento de , Ferreira Ana Hellen Marques , Lima Lucas Maciel Falcão de , Santos Maria Vanessa Pereira dos Santos , Barbosa Marco Antonio Martins Barbosa , Palhares Rafael Andrade , Santiago Samara Cardoso da Silva , Medeiros Maria Angelina da Silva Medeiros 
Published: January 2025

Células-tronco são células indiferenciadas que estão presentes nas fases da vida embrionária, fetal e adulta. Vesículas extracelulares (VEs) são corpos em nanoescala, envolvidos por membrana, secretadas por uma variedade de células, como células embrionárias, células T, células B, células cancerígenas, células de Schwann, células dendríticas, células neuronais, dentre outras. Na atualidade, uma variedade de estudos indica que exossomos secretados pelas MSCs podem substituir as terapias baseadas em células-tronco mesenquimais em inúmeras formas de lesões e doenças. Dessa maneira, aplicabilidades terapêuticas de vesículas extracelulares derivadas de células-tronco multipotentes são mais investigadas em comparação com outras células fontes, como células-tronco pluripotentes. O presente trabalho, trata-se de uma revisão integrativa onde apurou-se inicialmente quarenta estudos, dentre os quais foram selecionados um total de dez trabalhos para uma análise final, após a verificação dos critérios de inclusão e exclusão. Os estudos selecionados para a elaboração deste trabalho revelaram diversas vertentes de atuação das MSCs-EVs, com objetivos ligeiramente distintos. A abordagem mais comumente citada foi a sua capacidade como mecanismo imunomodulador e influenciador de processos inflamatórios, por meio de consideráveis evidências que apoiam o seu uso para manejo de doenças de cunho autoimune. Esta revisão de literatura oferece uma visão ampla do potencial de aplicação das VEs provenientes de CTs multi e pluripotentes; entretanto, revela-se a necessidade premente de um número maior de estudos que possam promover uma análise mais conclusiva do tópico.
IMPACTOS PSICOSSOCIAIS DO DIAGNÓSTICO E TRATAMENTO ONCOPEDIÁTRICO NA PERSPECTIVA DE FAMILIARES E/OU CUIDADORES
Authors: Mineshita Bruno Kenji Hosoda , Alves Ana Luise de Aguiar , Baia Fernando Gabriel Rodrigues , Nascimento Hozana Amanda dos Santos , Pinheiro Lourrana Silva , Soeiro Ana Cristina Vidigal 
Published: January 2025

Introdução: Durante o tratamento oncológico infantojuvenil, os familiares/cuidadores estão vulneráveis a questões que podem causar sobrecargas emocionais e impactar em sua qualidade de vida, como o medo de recidivas, a incerteza sobre a efetividade do tratamento e a mudança de vida. Objetivo: avaliar a sobrecarga emocional e a qualidade de vida dos cuidadores/familiares de pacientes oncopediátricos, tendo como cenário a Casa de Apoio Ronald Mcdonalds, localizada em Belém do Pará, Brasil. Métodos: Estudo observacional, descritivo e quantitativo, realizado na Casa de Apoio Ronald Mcdonald Belém do Pará, Brasil. O estudo teve 33 participantes. A coleta de dados foi realizada utilizado um protocolo de pesquisa composto por três seções: dados sociodemográficos, avaliação de sobrecarga (Zarit) e qualidade de vida (World Health Organization Quality Of Life - Bref). A tabulação foi feita no Microsoft Office Excel 2021 e a análise foi realizada pele teste de normalidade Shapiro-Wilk e correlação de Spearman, por meio do software Statistical Package for the Social Sciences 29.0 e Bioestat 5.0. O estudo foi aprovado pelo Comitê de Ética, parecer: 6.391.740 Resultados: Dos 33 entrevistados, 90,91% eram mulheres entre 30 a 39 anos (n=11/ 33,33%), mães (n=25/ 75,76%), com permanência na casa de até 1 ano (n=21/ 63,64%), católica (n=20/ 60,61%) e impossibilitado de manter sua atividade laboral (n=27/ 81,82%). Foi identificado sobrecarga moderada em 45,5%. As menores médias do escores da qualidade de vida foram para o domínio meio ambiente (3.20 ± 0.52) e satisfação com a saúde (3.24 ± 1.25. Conclusão: O presente estudo evidenciou que familiares/ cuidadores de pacientes oncopediatricos da casa de apoio estão sujeitos a sobrecarga moderada, em sua maioria, e uma redução da qualidade de vida proporcional ao aumento da sobrecarga.
Palavras-chave: Cuidadores. Oncologia. Qualidade de vida. Sobrecarga dos cuidadores.
Enantioselectivity in Pharmacokinetics: A Mini Review
Authors: Laldinchhana  , Lalrengpuii Judy , Komu Lobsang Tenzing , Roy Probin Kr 
Published: January 2025

Enantiomerism or drug chirality is one of the major concerns in drug discovery and development since more than 50% of currently marketed drugs are chiral compounds. Chiral molecules are also called enantiomers where a molecule contains at least one asymmetric carbon. Chiral inversion is an important phenomenon in which an enantiomer may convert from one enantiomeric configuration to the other which can be unidirectional or bidirectional. Enantiomers, though similar in their chemical structure, show noticeable differences in their biological properties. Therefore, a thorough knowledge of racemic drugs is important in the drug developmental stages to eliminate inactive or toxic isomers. Different databases such as ‘ScienceDirect’ and ‘Google Scholar have been used to search the articles using keywords Absorption of chiral compounds; Chirality in pharmacology; Enantiomers; Enantioselectivity; and Pharmacokinetics. With the advancement in synthetic chemistry, the development of a single enantiomer could potentially improve the overall development and manufacturing process of drugs. The current review addresses the nomenclature and enantioselectivity of enantiomers in various pharmacokinetic parameters such as absorption, distribution, metabolism and excretion.
Comparative Evaluation of Cinnamomum Cassia and Cinnamomum Zeylanicum Microemulgels: Exploring the Potential of Cinnamon Essential Oil Formulations
Authors: Bajpai Aishvi , Wani Ashiwni , Shinde Korlekar Pradnya , Mahule Shivani , Nagarsenkar Mangal 
Published: January 2025

Background: Plant essential oils have been identified as potential alternatives or additions to topical antimicrobial formulations. Cinnamon Essential Oil (CEO), offers potential as an alternative to topical antimicrobials, addressing the threat of antimicrobial resistance. Excessive use of antibiotics drives resistance, necessitating safe and effective treatments. CEO's active components, cinnamaldehyde, and eugenol, exhibit strong antimicrobial properties.
Objectives: This study focuses on the formulation design and antibacterial activity of topical microemulgels containing different variants of Ceylon and Cassia Cinnamon oils. It examines how the microemulgel formulation enhances the skin's absorption and delivery of active ingredients, leading to improved efficacy.
Method: The particle size, Polydispersibility Index (PDI), and Minimum Inhibitory Concentration (MIC) of both variants of cinnamon oil microemulgels were investigated. Additionally, in-vitro permeation and in vivo, acute skin irritation studies were conducted on the microemulgels.
Results: The study revealed that S.aureus and P.aeruginosa showed increased susceptibility to microemulgels containing Ceylon cinnamon oil (Cinnamomum zeylanicum) and Cassia cinnamon oil (Cinnamomum cassia), suggesting the efficacy of cinnamon oil as an antimicrobial agent.
Conclusion: The findings carry wider significance for pushing forward research and innovation in topical drug delivery through essential oils. This effort aims to rejuvenate the efficacy of antibiotics and foster the creation of novel therapeutic methods for prevalent, minor skin infections.
Synthesis and Characterization of Mint Leaf (Mentha Spicata) Biological Silver Nanoparticles and their Impact on Rat’s Motor Coordination and Cognition
Authors: Nagilla Bhaskar , Ajmeera Anusha , Sultana Katija , Reddy Pratap K 
Published: January 2025

Background: The utilization of silver nanoparticles is rising, since nanotechnology is blossoming in daily products and biomedicine. According to research on animals, silver nanoparticles can damage the brain, liver, kidneys, intestines, and lungs, among other organs. Several studies have found a link between various methods of administering nanoparticles and cognitive and behavioral impairments.
Objective: The current study aims to investigate the impact of mint leaf silver nanoparticles on rats' psychological behavior.
Method: Silver nanoparticles were prepared using fresh leaves of mint as bioreducing agents. It was verified that silver nanoparticles were formed via characterization with UV spectroscopy, fluorescence spectroscopy, FTIR analysis, SEM, energy dispersive X-ray spectroscopy (EDX), and Zeta potential. Rats were treated with silver nanoparticles for 21 days orally (50 mg/kg body weight) and were tested for cognitive function of learning in the form of Morris water maze (MWM), nociception was studied by the Eddy hot plate test (HPT), Randal pain test (RPT), motor coordination was done by the Roto rod test (RRT), and depression-like behavior was studied with the Porsolt forced swim test (FWT).
Results: UV spectroscopy has revealed a peak at 420 nm indicating the formation of green silver nanoparticles; the fluorescent spectrum showed a peak at 400 nm displaying the fluorescent activity of synthesized silver nanoparticles. FTIR showed that silver nanoparticles were capped with mint leaf secondary metabolites. Even Zeta potential analysis confirmed the green nanoparticles; SEM has shown the spherical shape of silver nanoparticles; and X-rays with energy dispersive spectra reveal the constituent elements of silver generated at 3 keV. Learning and memory abilities of rats screened with MWM, HPT, RPT, RRT, and FWT. Data have revealed variations in test results between animals exposed to nanoparticles in comparison with control animals.
Conclusion: This study concludes that nanoparticles therapy in rats impairs learning, memory, and other behavioral abilities.
Design and Formulation of Cyclodextrin based Nano-sponges Loaded Topical Hydrogel with Enhanced Skin Permeation and Effectiveness of Luliconazole
Authors: Patel Ashwini , Desai Sakshi , Pandey Prachi 
Published: January 2025

Objective The purpose of this work was to develop an effective luliconazole topical formulation. Cyclodextrin-based nanosponges loaded hydrogel of Carbopol 934 was formulated and characterized for its in-vitro and ex-vivo permeation study.
Methods Cyclodextrin-based nanosponges were prepared in a 1:3 ratio using the dispersion-sonication method. The effectivity of topical formulation is based on its spreadability and diffusion flux. 33 Factorial design was utilized for the optimization of the hydrogel formulation using spreadability and diffusion flux as dependent variables. Optimization was done by response surface methodology by keeping the constraint constant. The optimized batch was evaluated for ex vivo skin permeation and in vitro antifungal assay in comparison to marketed and plain drug-loaded hydrogel.
Result The prepared nanosponges were of nano size and had more than 80% drug content. Powder characterization confirms the compatibility between drug and excipients and the formation of inclusion complex with cyclodextrin. Based on desirability, optimized hydrogel follows the Higuchi kinetic model of drug release with better ex vivo diffusion compared to the marketed formulation. In vitro, antifungal assay showed better effectivity of hydrogel against Candida albicans. The topography of the gel showed an irregular spherical shape. Accelerated stability studies also confirmed the stabilization of the complex in the hydrogel.
Conclusion The prepared formulation shows better effectivity and penetrability due to spherical shape and presence of penetration enhancer and can improve patient compliance.
Revolutionizing Hypertension Management: AI-Powered Precision Medicine Approaches
Authors: Patel Aishwarya , Kankva Divyesh , Prajapati Parixit 
Published: January 2025

Precision medicine, also known as personalized medicine, represents a promising paradigm shift in hypertension management Precision medicine endeavours to improve treatment effectiveness and reduce adverse effects by customizing therapies to individual patients, considering their distinct characteristics and genetic makeup. Over the past few years, the incorporation of artificial intelligence (AI) into hypertension therapy has significantly advanced the principles of precision medicine, revolutionizing the assessment, monitoring, and control of high blood pressure. This review delves into the theoretical underpinnings of precision medicine in hypertension treatment, elucidating the pivotal role of AI in optimizing patient care. Moreover, it evaluates the potential benefits and drawbacks associated with the adoption of these innovative approaches. The aim of this review is to offer a thorough insight into how precision medicine, empowered by artificial intelligence, is transforming the landscape of hypertension management. Ultimately, this exploration aims to underscore the ground-breaking potential of AI in fundamentally changing the approach to hypertension treatment, offering insights into future directions for research and clinical practice.
Analisis Pengelolaan Pengaduan Masyarakat melalui Aplikasi JAKI dalam Rangka Pelayanan Publik di DKI Jakarta
Authors: Haekal Muhammad , Tjenreng Muhammad Baharuddin Zubakhrum 
Published: January 2025

This research discusses the functions of government in public service delivery and community empowerment based on Ndraha's theory (2003). The primary functions of government include high-quality public services, while secondary functions focus on community empowerment. Law No. 25 of 2009 regulates public complaint mechanisms as a form of public participation to improve service quality. The Jakarta Kini (JAKI) application, developed by the DKI Jakarta Provincial Government, serves as a smart governance-based platform for managing public complaints. JAKI's results indicate a 97.9% resolution rate, with 89% of complaints submitted through the application. Challenges such as digital literacy and technical issues need to be addressed to ensure JAKI remains effective in achieving transparent, responsive public services based on good governance principles.
The Effect Of Working Capital Efficiency And Liquidity On Profitability
Authors: Wibowo Wadudi 
Published: January 2025

This study aims to determine the effect of working capital efficiency and liquidity on profitability. The variables used in this research are working capital efficiency and liquidity of independent variable and profitability as dependent variable. Working capital efficiency is measured by working capital (X1), liquidity is measured by the current ratio (X2), and profitability measured by return on assets (Y).
The object of this research is conducted in the food and beverage industry in Indonesia Stock Exchange period 2015-2020, as many as 8 companies. The samples used are 48 companies. The regression model using panel data regression and regression model used is the Common Effect Model.
In statistical test study states that the working capital turnover (X1) is not significant to the return on assets (Y) and the current ratio (X2) has a significant positive effect partially on return on asset (Y).

Keywords: Working Capital Turnover, Current Ratio, Return on Asset