bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Analytical Model for Dynamic Spectrum Sensing in Cognitive Radio Networks using Blockchain Management
Authors: Marriwala Nikhil , Taneja Simran 
Published: October 2021

Abstract
The recent advances in wireless communication have led to the problem of growing spectrum scarcity. The problem of spectrum allocation is due to advance research in wireless communication. As new wireless applications are emerging, day after another, and making use of the available wireless spectrum for communication, the demand for spectrum increase makes the available spectrum scarcer. Mostly part of the spectrum is not utilized significantly in the wireless network. Cognitive Radio (CR) is a new technology that enables an unlicensed secondary user to coexist with licensed primary users in licensed spectrum bands without inducing interference to licensed primary users communication. This technology can significantly ease the spectrum redundancy problem & enhance the efficiency of utilization of spectrum. Cognitive Radio Networks (CRN) or Dynamic Spectrum Access Networks are formed by several CR nodes and they are often called NeXt Generation (XG) communication networks. This XG communication network is expected to give high transfer speed to versatile clients through heterogeneous remote designs and dynamic range access procedures. CRNs have drawn in incredible exploration interest in the new years. Nonetheless, research on the security parts of CRNs has been exceptionally restricted. As CRN is like a remote organization, the idea of the remote media is outside, it is more helpless against assaults when contrasted with that of a wired organization. This channel might be stuck/abuse due to remote media information is to be listened to.
Effects of Nitrogen Fertilizer and Faba Bean Density in Rotation on Maize Production and Soil Parameters Under No-Till System
Authors: Ghorbi Samaneh , Ebadi Ali , Khomari Saeid , Hashemi Masoud 
Published: October 2021

Abstract
Achieving food security and environmental sustainability is a huge global challenge. Thus, the use of conservation Agriculture systems seems necessary. We investigated the effects of nitrogen fertilizer and various densities of faba bean ( vicia faba L.) on forage corn (Zea mays L.) production in the no-till system with faba bean residues preservation on the soil surface. The effect of faba bean densities on yield and its yield components, as well as soil chemical and physical properties, was studied Simultaneously. The results showed that various densities of faba bean and nitrogen fertilizer increased dry biomass production of forage corn by improving N content in plants, which was achieved by the density of 40 plants per m2 of faba bean + application of 200 kg N ha−1 of maize. Moreover, N content, crude protein, and fresh biomass production in forage corn were significantly increased by faba bean density and nitrogen fertilizer. Faba bean density also affected on yield and yield component of faba bean, and the highest nitrogen released value of faba bean root residues was obtained from the density of 40 plants per m2 and application of 200 kg N ha−1. Therefore, the density of 40 plants per m2 of faba bean in a rotation system with mays and application of 200 kg N ha−1 be recommended as a fertilizer control method where it reduces the application of N fertilizer and increases the sustainability of production in agricultural systems.
Physical and Mental Well-Being of Women in Neurodiverse Relationships : A Comparative Study
Authors: Arad Pnina , Shechtman Zipora , Attwood Tony 
Published: October 2021

Abstract
BackgroundThere are very few studies which look into the ways in which autism spectrum disorder (ASD) impacts romantic relationships. The existent sources of information indicate that women in neurodiverse relationships experience extreme emotional deprivation and suffer from severe harm to their physical and mental well-being. The aim of the present study was to conduct empirical research into the question of whether a relationship between a neurologically typical woman and a man with high-functioning autism is significantly different from a neurologically typical relationship and what effects relating with someone with autism may have on the physical and mental state as well as sense of well-being of neurologically typical women. MethodsThe research population included 648 women in three groups: 228 women whose partners were formally diagnosed on the autism spectrum; 203 women who suspected their partners to be on the autism spectrum; 217 women in the control group, with neurotypical partners, who were neither diagnosed nor was there any suspicion of autism. Data collection was performed through online self-report questionnaires. Data analysis was conducted with SPSS ver. 24.ResultsFindings showed significantly higher rates of psychological and physical abuse reported by women in neurodiverse relationships (study groups), in comparison to women in neurologically typical relationships (control group). Women in the study groups reported significantly lower perceived physical health, more somatic symptoms and higher somatic symptom severity, as well as significantly higher levels of depression, higher depressive symptom severity and significantly lower levels of subjective well-being than women in the control group. There was no significant difference between women whose partners have been formally diagnosed with autism and for women who suspect their partners to be on the autism spectrum. LimitationsThe main limitations of the study were reliance on self-report instruments, the use of convenience sampling and the impossibility of pointing towards causation.ConclusionsThe present study with its preliminary findings enriches the current literature, which is lacking. These findings help to better understand the condition of women in neurodiverse relationship and support the need to provide better therapy and health services for women and couples in neurodiverse relationships.
Positive and Negative Effects of Republicanism on US citizens’ Mobility During the First Period of the COVID Crisis
Authors: Barbalat Guillaume , Franck Nicolas 
Published: October 2021

Abstract
While Republican states have been criticized for their limited efforts to contain the spread of COVID-19, it is important to consider that political orientation can modify human behaviour via complex effects that are still poorly understood. During the first period of the pandemic, we found that the association of republicanism with US citizens' mobility varied depending on the nature of the exposure being considered. First, republicanism was associated with increased mobility when the stringency of anti-COVID measures increased. Second, republicanism was associated with decreased mobility when COVID-related deaths increased. Third, republicanism was associated with increased mobility over time, i.e. as time went by, citizens living in Republican states were more mobile than those in Democratic states. These findings raise caution on any over-interpretation of the impact of polarization in US politics on COVID-related behaviour. They prompt consideration of persuasive tools that emphasize risk perception to promote social distancing in Republican states, rather than relying heavily on stringent anti-COVID interventions.
Evaluation of Pediatric-Specific Wheelchair-Skills-Training Tools By Primary Users: A Descriptive Qualitative Study
Authors: Ouellet Béatrice , Rushton Paula W , Côté Andrée-Anne , Fortin-Haines Laurence , Lafleur Emma , Paré Isabelle , Barwick Melanie , Kirby R. Lee , Robert Maxime T , Routhier François , Burrola-Mendez Yohali , Best Krista L 
Published: October 2021

Abstract
Background

Children’s ability to engage in meaningful occupations is positively influenced by their ability to move independently. Preliminary evidence in children suggests that wheelchair skills training improves wheelchair skills, which are critical for wheelchair mobility. The Wheelchair Skills Training Program is a standardized program to teach wheelchair skills. However, it is underutilized in pediatric rehabilitation settings. To address perceived barriers to training, three pediatric-specific Wheelchair Skills Training Program tools for indoor skills were developed (i.e., a storybook, four instructional posters, and a workbook). This study aimed to document occupational therapists’ and pediatric manual wheelchair users’ satisfaction and perspectives on the usability, relevance, and feasibility of these tools.
Method

A descriptive qualitative research design was used. A focus group was conducted with occupational therapists and interviews were conducted pediatric manual wheelchair users to obtain their feedback on the tool prototypes to facilitate refinement and to ensure they meet users’ needs.
Results

Eight occupational therapists and five pediatric manual wheelchair users expressed general satisfaction with the tools, describing them as usable, relevant and feasible to integrate into wheelchair skills training with novice wheelchair users and younger children. All occupational therapists and three pediatric manual wheelchair users expressed the desire to use the tools for wheelchair skills training. Two children expressed that the tools were more relevant for beginner wheelchair users only. The participants suggested minor modifications to make the tools more accessible for children (e.g., more action in the story, increased precision of illustrations related to the characters’ position in the wheelchair).
Conclusion

Occupational therapists and pediatric manual wheelchair users perceived the tools to have high potential to facilitate the use of the Wheelchair Skills Training Program in pediatric rehabilitation settings. After making the recommended modifications, the tools will be ready for pilot testing in pediatric rehabilitation settings.
Generation of a Novel High-Affinity Antibody Binding to PCSK9 Catalytic Domain with Slow Dissociation Rate by CDR-Grafting, Alanine Scanning and Saturated Site-Directed Mutagenesis
Authors: Bai Zhengli , Xu Menglong , Mei Ying , Hu Tuo , Zhang Panpan , Chen Manman , Lv Wenxiu , Lu Chenchen , Tan Shuhua 
Published: October 2021

Abstract
Inhibition of Proprotein convertase subtilisin/kexin type 9 (PCSK9) has become an attractive therapeutic strategy for lowering low-density lipoprotein cholesterol (LDL-C). In this study, a novel high affinity humanized IgG1 mAb (named h5E12-L230G) targeting the catalytic domain of human PCSK9 (hPCSK9) was generated by using CDR-grafting, alanine-scanning mutagenesis, and saturated site-directed mutagenesis. To eliminate the cytotoxic effector functions and mitigate the heterogeneity, the heavy-chain constant region of h5E12-L230G was modified with L234A/L235A/N297G mutations and C-terminal lysine deletion. The biolayer interferometry (BLI) binding assay and molecular docking study revealed that h5E12-L230G binds to the catalytic domain of hPCSK9 with nanomolar affinity (KD =1.72 nM) and an extremely slow dissociation rate (koff, 4.84 × 10−5 s−1), which interprets its quite low binding energy (-54.97 kcal/mol) with hPCSK9. Additionally, h5E12-L230G elevated the levels of LDLR and enhanced the LDL-C uptake in HepG2 cells, as well as reduced the serum LDL-C and total cholesterol (TC) levels in hyperlipidemic mouse model with high potency comparable to Alirocumab. Our data suggest that h5E12-L230G is a highly potent antibody binding to PCSK9 catalytic domain with slow dissociation rate which may be utilized as a therapeutic candidate for treating hypercholesterolemia and relevant cardiovascular diseases.
Clinical Characteristics and Outcomes of Exertional Rhabdomyolysis after Indoor Spinning: A Systematic Review
Authors: Masuda Yoshio , Wam Rachel , Paik Benjamin , Ngoh Clara L.Y. , Choong Andrew M.T.L , Ng Jun Jie 
Published: October 2021

Abstract
ObjectivesMore patients are being diagnosed with exertional rhabdomyolysis secondary to indoor spinning. We conducted a systematic review to characterize the clinical characteristics of this new clinical entity.MethodsWe conducted a thorough literature search on PubMed, Embase, Web of Science, Scopus and The Cumulative Index to Nursing and Allied Health Literature (CINAHL). Articles published from inception till 23rd June 2021 were considered for inclusion. A two-stage article selection process was performed. Articles that reported clinical characteristics and outcomes for patients with SIER were included. Quality assessment was performed using the Joanna Briggs Institute checklists.ResultsThere was a total of 22 articles and 97 patients with SIER. Most patients were healthy females who had attended their first spinning session. The average time to clinical presentation was 3.1 ± 1.5 days. The most common presenting symptoms were myalgia, dark urine and muscle weakness involving the thigh. Seven patients (7.2%) developed acute kidney injury, and two patients (2.1%) required temporary inpatient haemodialysis. Four patients (4.1%) developed thigh compartment syndrome and required fasciotomies. There were no long-term sequelae or mortality observed. The average length of stay was 5.6 ± 2.9 days.ConclusionsHealthcare professionals must have a high index of suspicion of SIER if any patient presents with myalgia, dark urine or weakness after a recent episode of indoor spinning. Fitness centre owners, spinning instructors and participants should also be better educated about the clinical characteristics and manifestations of SIER.
Insight into the structure of black coatings of ancient Egyptian mummies by advanced EPR spectroscopy of vanadyl complexes.
Authors: Dutoit Charles-Emmanuel , Binet Laurent , Vezin Hervé , Anduze Océane , Lattuati-Derieux Agnès , Gourier Didier 
Published: October 2021

Abstract
Advanced EPR techniques such as ENDOR and pulsed EPR are used to investigate the enigmatic black coatings of ancient Egyptian mummies, consisting in a complex and heterogeneous mixtures of conifer resins, wax, fat and oil with variable amounts of bitumen. Natural bitumen always contains traces of vanadyl porphyrin complexes that we used here as internal probes to explore the nanoscale environment of V4+ ions in these black coatings by hyperfine spectroscopy. Four types of vanadyl porphyrins were identified from the analysis of 14N hyperfine interactions. Three types (referred to as VO-P1, VO-P2 and VO-P3) are present in natural bitumen from the Dead Sea, among which VO-P1 and VO-P2 are also present in black coatings of mummies. The absence of VO-P3 in mummies, which is replaced by another complex VO-P4, may be due to its transformation during preparation of the black matter for embalming. Analysis of 1H hyperfine interaction shows that bitumen and other natural substances are intimately mixed in these black coatings, with bitumen aggregate sizes not larger than a few nanometres.
Construction of Immune-gene-pairs and Prognostic Model and its Immune Cell Infiltrationin in Glioblastoma — A Study based on TCGA and GTEx
Authors: Wei Yongxiang , Shi Jixin 
Published: October 2021

Abstract
Background: Gliomas are the most common primary intracranial tumor, containing 81% of brain malignant carcinoma. Glioblastoma is a primary brain tumor with a very poor prognosis. Existing treatment methods have many limitations, so more in-depth researches are urgently needed. Results: To screen key genes and build models, we made full use of RNA sequencing (RNA-seq) data from TCGA and GTEx and perform immune infiltration analysis in multiple immune-related databases. Finally, we screened key genes and build the model. Meanwhile, we explored immune cell infiltration. KEGG and GO analysis prompted us COVID-2019 may have potential relation with GBM. Further selection of immune-related differential genes and gene-pairs were then explored. The prognosis model built by lasso regression was tested to have great effect. Key genes were all found to have quite diverse expression level compared with normal samples. Moreover, their co-expression analysis reminded us more attention could be paid to WNT and NOTCH signaling. Immune infiltration suggests that most immune cells are differentially expressed in tumor samples, and the interaction reminded us B cells may play a critical role. Conclusion: This study is the first to build immune-gene-pairs and used lasso regression to construct the model and screen critical pairs. Key genes were then selected and observed their role in GBM.
Comparison Between Fasting and Non-Fasting Cut-Off Values of Triglyceride in Diagnosing High Triglyceride in Chinese Hypertensive Outpatients
Authors: Xie Yingying , Qu Peiliu , Wen Tie , Liu Ling , Du Xiao , Zhang Shilan , Guo Liling , Xiang Qunyan , Lin Qiuzhen , Xu Jin , Zhu Liyuan , Tan Yangrong , Fu Yan , Zhang Miao , Zang Xueyan 
Published: October 2021

Abstract
Background: Hypertension (HBP) often occurs together with hypertriglyceridemia that indicates elevated triglyceride (TG) and remnant cholesterol (RC) levels. Non-fasting (i.e. postprandial) blood lipid test after a daily meal has been recommended by the European Atherosclerosis Society (EAS). However, little is known about the difference between fasting and non-fasting cut-off values in assessing high TG (HTG) and high RC (HRC) in HBP outpatients.Methods: Two hundred and twenty-five Chinese outpatients with HBP were enrolled in this study. According to the time of blood lipid test, they were divided into two groups, i.e. the fasting group (n=119) and the non-fasting group (n=139). Non-fasting levels of blood lipids at 2 h after a daily breakfast were also tested in 33 patients among the fasting group. Venous blood samples were collected. Serum levels of blood lipids were measured by the enzymatic and direct methods on a HITACHI 7170A analyzer or estimated via related formulas. Results: The non-fasting group had significantly higher levels of TG and RC while lower levels of total cholesterol, low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol than the fasting group (P＜0.05). According to TG and RC cut-off values of the EAS, the percentages of HTG and HRC in the non-fasting group were 67.6% and 65.6%, respectively, while those in the fasting group were 57.1% and 52.9%, respectively. However, the percentages of HTG in the fasting state and at 2 h after a daily breakfast in 33 outpatients did not reach statistical significance (57.6% v.s. 51.5%). So did the fasting and at 2 h non-fasting percentages of HRC in them.Conclusion: Non-fasting blood lipid test could find more HBP outpatients with HTG in Chinese outpatients with HBP. However, the percentage of HTG at 2h after a daily breakfast seemed to be close to that in the fasting state.
Generation of Genome-Edited Dogs by Somatic Cell Nuclear Transfer
Authors: Kim Dong-Ern , Lee Ji-Hye , Ji Kuk-Bin , Park Kang-Sun , Kil Tae-Young , Koo Okjae , Kim Min-Kyu 
Published: October 2021

Abstract
Background: Canine cloning technology based on somatic cell nuclear transfer (SCNT) combined with genome editing tools, such as CRISPR/Cas9, can be used to correct pathogenic mutations in purebred dogs or to generate animal models of disease.Results: In this study, we constructed a CRISPR/Cas9 vector construct targeting the canine DJ-1 gene. Genome-edited canine fibroblasts were established by transfection of the vector following antibiotic selection. We performed canine SCNT using genome-edited fibroblasts and successfully produced two genome-edited dogs. Both genome-edited dogs had indel mutations at the target locus, and expression of the DJ-1 gene was downregulated or completely repressed.Conclusion: In conclusion, SCNT successfully produced genome-edited dogs using the CRISPR/Cas9 system for the first time.
Correlation of Diabetes and Cancers: A Survey of Hospitalized Patients in the United State, 2005-2015
Authors: Mirahmadizadeh Alireza , Sharifi Mohammad Hossein , Aryaie Mohammad , Gheibi Zahra , Rezvani Alireza , Zeighami Shahryar , Heiran Alireza , Seifi Ali 
Published: October 2021

Abstract
BackgroundIn recent decades, there is a growing body of literature that recognizes the relationship between diabetes and cancers. However, there is limited and contradictory evidence regarding whether diabetes is associated with an increased or decreased risk of some cancers.MethodIn this survey, data from 44,262,443 patients aged ≥50 years from 2005 to 2015 were obtained from the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample (HCUP-NIS) database. Univariate analysis and multivariate logistic regression between diabetes and 33 selected cancers among hospitalized patients were calculated from data extracted from the database.ResultsThis study revealed that out of 44,262,443 discharges, 13,048,961 patients had diabetes for a prevalence of 29.48%, and 11,752,871 cases of 33 different cancers existed among 9,103,889 patients. Data revealed that the proportion of patients hospitalized with diabetes increased from 25.79% to 32.31% in uncomplicated diabetes (mean age: 70.11±11.07 years) and from 4.47% to 7.14% in complicated diabetes (mean age: 68.71±10.72 years). The univariate analysis and multivariate logistic regression analysis revealed that diabetes, including uncomplicated and complicated, had a protective role for 33 selected cancers as the 1st–30th diagnosis except for pancreatic cancer (OR 1.415, 95% CI: 1.40–1.43), and liver and intrahepatic cancer (OR 1.199, 95% CI: 1.184–1.213).ConclusionThis study presents new information on the likelihood of a protective role of diabetes in certain cancers using a large amount of individual data. Continued efforts and research are needed to provide detailed and probable biological mechanisms linking diabetes and the development and progression of cancer.
Utility and Its Relationship With Disease Activity and Physical Disability of Patients With Psoriatic Arthritis in Thailand
Authors: Sawangjit Ratree , Dilokthornsakul Piyameth , Chiowchanwisawakit Praveena , Louthrenoo Worawit , Osiri Manathip , Sucheewasilp Jeeranun , Nampuan Sawanya , Permsuwan Unchalee 
Published: October 2021

Abstract
Physical disability and severity of skin disease are important factors for evaluating healthy utility in psoriatic arthritis (PsA) patient. This study aims to estimate health utility and its related factors incorporating both rheumatologic and dermatologic factors in PsA. This cross-sectional study performed in PsA patients in Thailand. EQ-5D-5L, Health Assessment Questionnaire Disability Index (HAQ-DI), and Psoriasis Area and Severity Index (PASI) tools were used to collect health utility, physical disability, and severity of psoriatic skin lesions by face-to-face interviewed. Linear regression analysis was performed to relate health utility and its related factors. Of 84 patients enrolled, 49 (58.3%) were female, 67 (79.8%) had remission or low disease activity. Eighty-three patients (98.8%) received conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) or biologic DMARDs (bDMARDs). The mean±SD overall utility was 0.87±0.15. The utility score of patients with low disease activity was significantly greater than those with moderate to severe disease activity (0.89±0.12 vs 0.72±0.19, p<0.001). The HAQ-DI (unstandardized β = -0.167, 95%CI; -0.218 to -0.116, p<0.001) and PASI (unstandardized β = -0.006, 95%CI; -0.009 to -0.003, p<0.001) were found to be significant related factors for utility. These results indicated that Thai patients with PsA had relatively high health utility. However, most included patients were in remission or had low disease activity. The HAQ-DI and PASI showed a strong predictors of patients’ health utility.