bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating Supply Functions for Wine Attributes: A Two-Stage Hedonic Approach
Authors: Oczkowski Edward 
Published: December 2021

AbstractA vast body of literature exists on estimating hedonic price functions, which relate the price of wine to its attributes. Some existing literature has employed producer-specific variables such as quantity sold and producer reputation in hedonic functions to potentially capture supply influences on prices. This practice is inconsistent with the original Rosen (1974) hedonic theoretic foundation. To overcome this deficiency, we extend the literature by using the Rosen two-stage approach, employing data from multi-markets for similar wines to estimate inverse supply functions. The application to Australian produced wines sold in different countries demonstrates the importance of a wine's quality and age as attributes in inverse supply functions. Results imply the additional costs of producing better quality and older wines are increased as both quality and age are increased. Estimates also suggest that lower marginal costs for attributes are associated with a smaller producer size and older more established producers. (JEL Classifications: C21, Q11)
Exposure to prenatal maternal distress and infant white matter neurodevelopment
Authors: Demers Catherine H. , Bagonis Maria M. , Al-Ali Khalid , Garcia Sarah E. , Styner Martin A. , Gilmore John H. , Hoffman M. Camille , Hankin Benjamin L. , Davis Elysia Poggi 
Published: December 2021

AbstractThe prenatal period represents a critical time for brain growth and development. These rapid neurological advances render the fetus susceptible to various influences with life-long implications for mental health. Maternal distress signals are a dominant early life influence, contributing to birth outcomes and risk for offspring psychopathology. This prospective longitudinal study evaluated the association between prenatal maternal distress and infant white matter microstructure. Participants included a racially and socioeconomically diverse sample of 85 mother–infant dyads. Prenatal distress was assessed at 17 and 29 weeks’ gestational age (GA). Infant structural data were collected via diffusion tensor imaging (DTI) at 42–45 weeks’ postconceptional age. Findings demonstrated that higher prenatal maternal distress at 29 weeks’ GA was associated with increased fractional anisotropy, b = .283, t(64) = 2.319, p = .024, and with increased axial diffusivity, b = .254, t(64) = 2.067, p = .043, within the right anterior cingulate white matter tract. No other significant associations were found with prenatal distress exposure and tract fractional anisotropy or axial diffusivity at 29 weeks’ GA, or earlier in gestation.
Longitudinal network model of the co-development of temperament, executive functioning, and psychopathology symptoms in youth with and without ADHD
Authors: Karalunas Sarah L. , Antovich Dylan , Goh Patrick K. , Martel Michelle M. , Tipsord Jessica , Nousen Elizabeth K. , Nigg Joel T. 
Published: December 2021

AbstractAttention-deficit hyperactivity disorder (ADHD) is a common, chronic, and impairing disorder, yet presentations of ADHD and clinical course are highly heterogeneous. Despite substantial research efforts, both (a) the secondary co-occurrence of ADHD and complicating additional clinical problems and (b) the developmental pathways leading toward or away from recovery through adolescence remain poorly understood. Resolving these requires accounting for transactional influences of a large number of features across development. Here, we applied a longitudinal cross-lagged panel network model to a multimodal, multilevel dataset in a well-characterized sample of 488 children (nADHD = 296) to test Research Domain Criteria initiative-inspired hypotheses about transdiagnostic risk. Network features included Diagnostic and Statistical Manual of Mental Disorders symptoms, trait-based ratings of emotional functioning (temperament), and performance-based measures of cognition. Results confirmed that ADHD symptom domains, temperamental irritability, and working memory are independent transdiagnostic risk factors for psychopathology based on their direct associations with other features across time. ADHD symptoms and working memory each had direct, independent associations with depression. Results also demonstrated tightly linked co-development of ADHD symptoms and temperamental irritability, consistent with the possibility that this type of anger dysregulation is a core feature that is co-expressed as part of the ADHD phenotype for some children.
Reducing suicide risk in parentally bereaved youth through promoting effective parenting: testing a developmental cascade model
Authors: Zhang Na , Sandler Irwin , Tein Jenn-Yun , Wolchik Sharlene 
Published: December 2021

AbstractChildren who experience parental death are at increased risk for suicide. The Family Bereavement Program (FBP) is an upstream preventive intervention for parentally bereaved families that was found to reduce suicide risk in parentally bereaved youth up to 6 and 15 years later. We tested whether FBP-induced improvements in effective parenting led to changes in multiple proximal factors that prior theory and research implicated in the cascading pathway to suicide risk, namely, aversive self-views, caregiver connectedness, peer connectedness, complicated grief, depressive symptoms, and emotion suppression. The sample was 244 bereaved youth and their surviving caregiver from 156 families. Families were randomized into the FBP (12 group-based sessions for parents, youth, and two joint sessions) or a literature control condition. Multimethod and multiinformant data were collected at baseline, posttest, 6-year and 15-year follow-up assessments. Results showed that program-induced improvements in effective parenting at posttest were associated with reduced aversive self-views and increased caregiver connectedness at the 6-year follow-up, and each mediator was in turn associated with reduced suicide risk at the 6- and 15-year follow-up. The mediated pathways via aversive self-views remained significant while controlling for caregiver connectedness. Self-related concepts may be important targets in upstream suicide prevention for at-risk youth.
The geometry of Bayesian programming
Authors: Dal Lago Ugo , Hoshino Naohiko 
Published: December 2021

AbstractWe give two geometry of interaction models for a typed λ-calculus with recursion endowed with operators for sampling from a continuous uniform distribution and soft conditioning, namely a paradigmatic calculus for higher-order Bayesian programming. The models are based on the category of measurable spaces and partial measurable functions, and the category of measurable spaces and s-finite kernels, respectively. The former is proved adequate with respect to both a distribution-based and a sampling-based operational semantics, while the latter is proved adequate with respect to a sampling-based operational semantics.
Youth, race and the inner-city estate: narratives of everyday life in Manchester's Hulme, 1970–1994
Authors: Carter Isabelle 
Published: December 2021

AbstractSince the 1970s, policy-makers and the press have rendered young people, particularly those of black and minority ethnic backgrounds, synonymous with ‘inner-city crisis’. Focusing upon the high-density, multi-storey Hulme estate in Manchester, this article seeks to transcend stereotypical representations of these residents and illuminate their perspectives of the inner city. Conceptualizing the inner city as both a discursive and lived space, the article traces the intersections between its representation and residents’ testimonies to assess how far residents used prevalent understandings of Hulme as a space of crime and social breakdown respectively to shape their narratives of everyday life.
Physics‐Based Narrowband Optical Parameters for Snow Albedo Simulation in Climate Models
Authors: Wang Wenli , He Cenlin , Moore John , Wang Gongxue , Niu Guo‐Yue 
Published: December 2021

AbstractAccurate snow albedo simulation is a prerequisite for climate models to produce reliable climate prediction. Climate models would benefit from schemes of snowpack radiative transfer that are responsive to changing atmospheric conditions. However, the uncertainties in the narrowband snow optical parameters used by these schemes have not been evaluated. Conventional methods typically compute these narrowband parameters as irradiance‐weighted averages of the spectral snow optical parameters, with the single scattering albedo being additionally weighted by the optically thick snowpack albedo. We first evaluate the effectiveness of the conventional methods as adopted by the widely used Community Land Model (CLM). Snow albedo calculations using the CLM narrowband optical parameters are relatively accurate for very thin snow (e.g., a bias of 0.01 for a 2‐cm snowpack). The error, however, becomes larger as snowpack thickens (with biases of up to 0.05 for semi‐infinite snowpack), because the snow radiative transfer is highly nonlinear and is most significant at wavelengths <1 μm. In this study, we propose a novel method to retrieve broadband optical parameters according to snow radiative transfer theory, reducing the albedo biases to <0.003 for 2 cm snowpacks and <0.005 for thick snowpacks. We find little impact in changing incident spectra on narrowband snow albedo. These newly derived narrowband optical parameters improve snow albedo accuracy by a factor of 10, allowing to trace the impacts of aerosol pollution in snow. The parameters are independent of which two‐stream approximation is used, and are thus applicable to sea ice, glaciers, and seasonal snow cover.
Strongly Coupled Data Assimilation of Ocean Observations Into an Ocean‐Atmosphere Model
Authors: Tang Q. , Mu L. , Goessling H. F. , Semmler T. , Nerger L. 
Published: December 2021

AbstractWe compare strongly coupled data assimilation (SCDA) and weakly coupled data assimilation (WCDA) by analyzing the assimilation effect on the estimation of the ocean and the atmosphere variables. The AWI climate model (AWI‐CM‐1.1) is coupled with the parallel data assimilation framework (PDAF). Only satellite sea surface temperature data are assimilated. For WCDA, only the ocean variables are directly updated by the assimilation. For SCDA, both the ocean and the atmosphere variables are directly updated by the assimilation. Both WCDA and SCDA improve ocean state and yield similar errors. In the atmosphere, WCDA gives slightly smaller errors for the near‐surface temperature and wind velocity than SCDA. In the free atmosphere, SCDA yields smaller errors for the temperature, wind velocity, and specific humidity than WCDA in the Arctic region, while in the tropical region, the errors are generally larger.
New Insights Into the Correlation Between Lightning Flash Rate and Size in Thunderstorms
Authors: Zheng Dong , Zhang Yijun 
Published: December 2021

AbstractThunderstorms over the Tibetan Plateau (TP), Central and Eastern China (CEC), and southern foothills of the Himalayas (SHF), have the correlations between lightning flash rate and size disagreeing with the previously published negative correlation in thunderstorms with different dynamics. There is a positive correlation when comparing TP and CEC thunderstorms. Compared with SHF thunderstorms, TP thunderstorms have much lower flash rate and similar flash size. It is explored that the TP and SHF thunderstorms have the weakest and strongest convection, respectively, and both have small effective charge regions (ECRs). The CEC and SHF thunderstorms contain more ECRs than TP thunderstorm. The weak convection in TP thunderstorm should be responsible for the common occurrence of small flash rate and size. The results suggest that the negative correlation between flash rate and size may require the dynamic intensity of compared thunderstorms to exceed a certain threshold.
Assessing the Vertical Velocity of the East Pacific ITCZ
Authors: Huaman Lidia , Schumacher Courtney , Sobel Adam H. 
Published: December 2021

AbstractReanalysis and satellite data sets disagree on the vertical structure of the meridional overturning circulation over the East Pacific (EP) intertropical convergence zone (ITCZ). Recent observations from the Organization of Tropical East Pacific Convection (OTREC) 2019 field campaign show a meridional slope of vertical motion with a shallow mode from 3° to 7°N, over a strong meridional sea surface temperature (SST) gradient, and a deeper mode from 7° to 10.5°N, where the SST is predominantly warm. However, reanalysis fields from the OTREC period show a predominant shallow mode from 3° to 9°N unless OTREC dropsondes are assimilated; then a weak deep mode is found at 8°N. Vertical motion over the OTREC region derived from Global Precipitation Measurement (GPM) precipitation radar latent heating retrievals has the opposite problem in that the deep mode is predominant from 3° to 10°N. A shallow mode is present with the addition of cloud radar data.
Soil Property Plays a Vital Role in Vegetation Drought Recovery in Karst Region of Southwest China
Authors: Xu Taoran , Wu Xiuchen , Tian Yuhong , Li Yang , Zhang Wen , Zhang Cicheng 
Published: December 2021

AbstractSouthwest China is the world's largest continuous karst region, where drought events are expected to intensify in the future. Understanding the postdrought recovery of vegetation growth sheds light on the resilience and stability of ecosystems and is of great importance to the sustainable management. However, the effects of the soil properties, beyond the climate variations, on the vegetation postdrought recovery are often overlooked and remain unknown. In this study, we characterized both the patterns and the underlying processes governing the postdrought recovery trajectories of vegetation growth after extreme droughts in karst regions of southwest China. Linear mixed‐effects model analyses revealed that higher mean Normalized Difference Vegetation Index (NDVI) preceding the spring/summer drought leads to shorter drought recovery time for both forests and grasslands, while opposite pattern appears in autumn/winter drought, particularly in forests. Significant effects of precipitation during recovery period were only found in grasslands but not in forests. More importantly, we discovered a crucial impact of the depth to bedrock on vegetation postdrought recovery in forests but not in grasslands, with deeper depth to bedrock associated to a shorter drought recovery. The field capacity is more important for postdrought recovery in karst regions than in nonkarst regions, which can be most likely attributed to differences in the water‐holding capacities and water use strategies of vegetation. Our understanding of the postdrought recovery of vegetation growth in karst regions will facilitate the reasonable prediction of ecosystem resilience and health to extreme climate events in such fragile ecological environments.
Palaeoceanography of the Japan Sea Across the Mid‐Pleistocene Transition: Insights From IODP Exp. 346, Site U1427
Authors: Felder Sonja , Sagawa Takuya , Greaves Mervyn , Leng Melanie J. , Ikehara Ken , Kimoto Katsunori , Hasegawa Siro , Wagner Thomas , Henderson Andrew C. G. 
Published: December 2021

AbstractLarge‐scale atmospheric circulation patterns, such as the East Asian monsoon, have been proposed as possible feedbacks of the mid‐Pleistocene transition (MPT). Marine sediments of the Japan Sea (JS) record variations in the East Asian monsoon over long timescales and may be crucial for understanding of the MPT. To interpret these sediments correctly an understanding of the JS palaeoceanography is necessary. So far, the JS palaeoceanography has been extrapolated across the MPT from studies of the most recent glacial‐interglacial cycles. These suggest a good connection and unrestricted water‐mass exchange with the open ocean during interglacial sea‐level highstands, while during glacial sea‐level lowstands the JS is nearly isolated. Glacial isolation often results in poor carbonate preservation and unusually low oxygen isotope (δ18O) ratios from low‐saline/low‐δ18O waters accumulating in the basin. Using the sediments of Integrated Ocean Drilling Program (IODP) Site U1427, a shallow‐water site in the southern JS, we present a continuous foraminiferal δ18O record encompassing the MPT. This record shows the JS‐typical low glacial δ18O values in the late phase of the MPT, across Marine Isotope Stages (MIS) 24‐17, while earlier MPT glacials, across MIS 39‐25, are characterized by high δ18O values. We propose that high glacial δ18O values are the result of an improved connection between the shallow, southern JS and adjacent ocean during early MPT glacials. The impact of this palaeoceanographic mode, if continued to deep‐water sites, would make the interpretation of dark/light sediment layers as glacial/interglacial deposits uncertain.
Runx1 protects against the pathological progression of osteoarthritis
Authors: Zhou Chenchen , Cui Yujia , Yang Yueyi , Guo Daimo , Zhang Demao , Fan Yi , Li Xiaobing , Zou Jing , Xie Jing 
Published: December 2021

AbstractRunt-related transcription factor-1 (Runx1) is required for chondrocyte-to-osteoblast lineage commitment by enhancing both chondrogenesis and osteogenesis during vertebrate development. However, the potential role of Runx1 in joint diseases is not well known. In the current study, we aimed to explore the role of Runx1 in osteoarthritis induced by anterior cruciate ligament transaction (ACLT) surgery. We showed that chondrocyte-specific Runx1 knockout (Runx1f/fCol2a1-Cre) aggravated cartilage destruction by accelerating the loss of proteoglycan and collagen II in early osteoarthritis. Moreover, we observed thinning and ossification of the growth plate, a decrease in chondrocyte proliferative capacity and the loss of bone matrix around the growth plate in late osteoarthritis. We overexpressed Runx1 by adeno-associated virus (AAV) in articular cartilage and identified its protective effect by slowing the destruction of osteoarthritis in cartilage in early osteoarthritis and alleviating the pathological progression of growth plate cartilage in late osteoarthritis. ChIP-seq analysis identified new targets that interacted with Runx1 in cartilage pathology, and we confirmed the direct interactions of these factors with Runx1 by ChIP-qPCR. This study helps us to understand the function of Runx1 in osteoarthritis and provides new clues for targeted osteoarthritis therapy.
Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome
Authors: Liu Xiaomin , Tong Xin , Zhu Jie , Tian Liu , Jie Zhuye , Zou Yuanqiang , Lin Xiaoqian , Liang Hewei , Li Wenxi , Ju Yanmei , Qin Youwen , Zou Leying , Lu Haorong , Zhu Shida , Jin Xin , Xu Xun , Yang Huanming , Wang Jian , Zong Yang , Liu Weibin , Hou Yong , Jia Huijue , Zhang Tao 
Published: December 2021

AbstractThe oral microbiota contains billions of microbial cells, which could contribute to diseases in many body sites. Challenged by eating, drinking, and dental hygiene on a daily basis, the oral microbiota is regarded as highly dynamic. Here, we report significant human genomic associations with the oral metagenome from more than 1915 individuals, for both the tongue dorsum (n = 2017) and saliva (n = 1915). We identified five genetic loci associated with oral microbiota at study-wide significance (p < 3.16 × 10−11). Four of the five associations were well replicated in an independent cohort of 1439 individuals: rs1196764 at APPL2 with Prevotella jejuni, Oribacterium uSGB 3339 and Solobacterium uSGB 315; rs3775944 at the serum uric acid transporter SLC2A9 with Oribacterium uSGB 1215, Oribacterium uSGB 489 and Lachnoanaerobaculum umeaense; rs4911713 near OR11H1 with species F0422 uSGB 392; and rs36186689 at LOC105371703 with Eggerthia. Further analyses confirmed 84% (386/455 for tongue dorsum) and 85% (391/466 for saliva) of host genome-microbiome associations including six genome-wide significant associations mutually validated between the two niches. As many of the oral microbiome-associated genetic variants lie near miRNA genes, we tentatively validated the potential of host miRNAs to modulate the growth of specific oral bacteria. Human genetics accounted for at least 10% of oral microbiome compositions between individuals. Machine learning models showed that polygenetic risk scores dominated over oral microbiome in predicting risk of dental diseases such as dental calculus and gingival bleeding. These findings indicate that human genetic differences are one explanation for a stable or recurrent oral microbiome in each individual.
Temporal distinguishability in Hong-Ou-Mandel interference for harnessing high-dimensional frequency entanglement
Authors: Chen Yuanyuan , Ecker Sebastian , Chen Lixiang , Steinlechner Fabian , Huber Marcus , Ursin Rupert 
Published: December 2021

AbstractHigh-dimensional quantum entanglement is currently one of the most prolific fields in quantum information processing due to its high information capacity and error resilience. A versatile method for harnessing high-dimensional entanglement has long been hailed as an absolute necessity in the exploration of quantum science and technologies. Here we exploit Hong-Ou-Mandel interference to manipulate discrete frequency entanglement in arbitrary-dimensional Hilbert space. The generation and characterization of two-, four- and six-dimensional frequency entangled qudits are theoretically and experimentally investigated, allowing for the estimation of entanglement dimensionality in the whole state space. Additionally, our strategy can be generalized to engineer higher-dimensional entanglement in other photonic degrees of freedom. Our results may provide a more comprehensive understanding of frequency shaping and interference phenomena, and pave the way to more complex high-dimensional quantum information processing protocols.
Long-acting capsid inhibitor protects macaques from repeat SHIV challenges
Authors: Vidal Samuel J. , Bekerman Elena , Hansen Derek , Lu Bing , Wang Kelly , Mwangi Judy , Rowe William , Campigotto Federico , Zheng Jim , Kato Darryl , Chandrashekar Abishek , Barrett Julia , Patel Shivani , Wan Huahua , Anioke Tochi , Mercado Noe B. , Nkolola Joseph P. , Ferguson Melissa J. , Rinaldi William J. , Callebaut Christian , Blair Wade , Cihlar Tomas , Geleziunas Romas , Yant Stephen R. , Barouch Dan H. 
Published: December 2021

AbstractBecause no currently available vaccine can prevent HIV infection, pre-exposure prophylaxis (PrEP) with antiretrovirals (ARVs) is an important tool for combating the HIV pandemic1,2. Long-acting ARVs promise to build on the success of current PrEP strategies, which must be taken daily, by reducing the frequency of administration3. GS-CA1 is a small-molecule HIV capsid inhibitor with picomolar antiviral potency against a broad array of HIV strains, including variants resistant to existing ARVs, and has shown long-acting therapeutic potential in a mouse model of HIV infection4. Here we show that a single subcutaneous administration of GS-CA1 provides long-term protection against repeated rectal simian–human immunodeficiency virus (SHIV) challenges in rhesus macaques. Whereas all control animals became infected after 15 weekly challenges, a single 300 mg kg−1 dose of GS-CA1 provided per-exposure infection risk reduction of 97% for 24 weeks. Pharmacokinetic analysis showed a correlation between GS-CA1 plasma concentration and protection from SHIV challenges. GS-CA1 levels greater than twice the rhesus plasma protein-adjusted 95% effective concentration conferred 100% protection in this model. These proof-of-concept data support the development of capsid inhibitors as a novel long-acting PrEP strategy in humans.