bluuebunny/crossref_metadata_2025_split huggingface dataset:
EVALUASI SETAHUN PELAKSANAAN JAMINAN PERSALINAN DALAM MENURUNKAN ANGKA KEMATIAN IBU DAN BAYI
Authors: Claramita Mora 
Published: January 2021

Proper insurance system is the first target of millennium development. Indonesian Ministry of Health offers an insurance system for helping reduce infant and maternal mortality rates: The Jampersal. Reproductive health for women and children is the second targets of MDGs . It has been 1 year of Jampersal implementation, therefore it needs to evaluate the effectiveness, especially in a remote area like Ternate in Northern Maluku. The study was conducted by collecting secondary quantitative data and primary qualitative data from 7 Puskesmas in Ternate (out of 8) in August-November 2012. Data were collected from 15 nursery mothers who underwent Jampersal insurance, from 15 midwives, 8 medical doctors and 1 obsgyn specialist from all districts Puskesmas in Ternate. Quantitative data were analyzed by descriptive statistics and qualitative data were analyzed by content analysis. that Jampersal was significantly increased documentation of medical record on mother who delivers the baby in Puskesmas; who were also increased in number. Previously lots of mother delivers at home with traditional birth attendances without proper documentation on medical records. It means that indirectly, Jampersal should have been helping in controling problems on reproductive and child health. However, it is not yet clear that Jampersal actually helps to reduce infant and maternal mortality rate due to many obstacles following the Jampersal implementations.
La contabilidad en tiempos de pandemia
Authors: Toledo Castillo Norma del Rocío , Peñafiel Moncayo Isabel Romané , Puente Vásquez Maritza Guadalupe 
Published: January 2021

Introducción. En este artículo, se quiere hacer un análisis de la importancia que sería llevar las cuentas en estos tiempos en donde se ha dado una desaceleración productiva global, de alguna manera se quiere recopilar el impacto económico que se está viviendo a nivel mundial y que factores contables se vuelven vulnerables en las decisiones que se tenga que tomar para salir de esta crisis que lamentablemente no solo es sanitaria sino económica y social. Conclusiones. El COVID-19 no solo trajo una crisis sanitaria sino política y social, como podemos observar la pobreza se incrementa, dándose un caso insólito, que no son los pobres los que salen a robar y asaltar, sino es este sistema corrupto se ha provocado que una elite politiquera asalte los recursos de los más pobres. La pandemia está provocando cambios en la historia de la humanidad. Este acontecimiento marcará antes y un después en la civilización humana. Es evidente que la brecha entre ricos y pobres después de esta pandemia será mucho mayor, especialmente en nuestros países, es por eso que hay que replantearse alternativas más sociales que vayan en beneficio de la humanidad y del medio ambiente.
Geochemical Analysis of Sediments from Sahaiawei-1 Well of the Northern Delta Depobelt in the Niger Delta Basin, Nigeria
Authors: Itiowe K. , Lucas F. A. , Avwenagha E. O. 
Published: January 2021

Geochemical analysis of sediments from Sahaiawei-1 Well of the Northern Delta Depobelt in the Niger Delta Basin was carried out to classify the sediments, determine the provenance, tectonic setting and depositional environment. Twenty (20) ditch cutting samples between 1500 and 10730 ft. were subjected to X-ray fluorescence analysis to determine the elemental composition. The result for the classification of the sediments shows that the sediments were classified as Fe-shale and Fe-sand. The discriminant function diagrams for provenance signature and tectonic setting show that the sediments were plotted within the quartzose sedimentary provenance and passive continental margin tectonic setting fields respectively. The depositional environment using inorganic geochemistry shows that the sediments were deposited with in the continental, transitional and marine environments. This research has provided up to date information on the geochemistry of the Northern Delta Depobelt which would help in hydrocarbon exploration in the area.
¿Quo Vadis COVID-19?
Authors: Cabezas César 
Published: January 2021

La crisis sanitaria, política, económica y social causada por el nuevo coronavirus SARS-CoV-2 causante de la COVID-19, marca un hito histórico para la humanidad en el último siglo. Casi todos los países del mundo están siendo afectados de manera indistinta, aquellos desarrollados y otros en vías de desarrollo con un impacto diferenciado, dejando no solo secuelas de muerte a su paso, sino además desentrañando serias limitaciones de los sistemas sanitarios de los países, siendo aún mayor en los países con marcadas deficiencias e inequidades.
Nunca es tarde para beneficiarse con el tratamiento para disminuir los lípidos
Authors: Calderón-Velasco Rolando 
Published: January 2021

En un grupo de habitantes entre 20 y 100 años que no tomaban estatinas o que tuvieran diabetes. En esta población, la elevada concentración del LDL estuvo relacionada con aumentado riesgo de infarto del miocardio y enfermedad cardiovascular ateromatosa en aquellos mayores de 70 años fue menor que en los individuos jóvenes.
Progression and Outcomes of Non-dysfunctional Bicuspid Aortic Valve: Longitudinal Data From a Large Korean Bicuspid Aortic Valve Registry
Authors: Song Shinjeong , Seo Jiwon , Cho Iksung , Hong Geu-Ru , Ha Jong-Won , Shim Chi Young 
Published: January 2021

Background: Using echocardiographic surveillance, many patients are diagnosed with bicuspid aortic valve (BAV) without significant valve dysfunction. Limited data are available regarding the progression and outcomes of non-dysfunctional BAV.Methods and Results: We investigated 1,307 BAV patients (984 male, mean age 56 years) diagnosed from Jan 2003 through Dec 2018 in a single tertiary center. Seven hundred sixty-one patients underwent follow-up echocardiography at ≥1 year post-diagnosis. Non-dysfunctional BAV was defined as BAV without moderate aortic stenosis (AS) or aortic regurgitation (AR). The presence of aortopathy was defined as an ascending aorta diameter &gt;37mm. Progression to significant BAV dysfunction, progression to severe aortopathy (ascending aorta diameter ≥45mm), and incidence of valve or aorta operation were analyzed. One hundred eighty-seven (25%) patients showed non-dysfunctional BAV. Among them, 104 (56%) had mild AS or AR, and 81 (43%) had aortopathy at indexed echocardiography. At 6.0 ± 3.8 years post-diagnosis, 56 (29%) progressed to dysfunctional BAV, 28 (15%) progressed to severe aortopathy, 22 (12%) underwent valve operation, and 19 (10%) experienced aorta operation. Eighty-nine percent of patients with normal BAV function and 61% of patients with mild AS or AR maintained non-dysfunctional BAV. More patients with aortopathy progressed to severe aortopathy (35 vs. 0% without aortopathy, p &lt; 0.001), with a higher incidence of aorta operation (21 vs. 2%, p &lt; 0.001).Conclusions: In patients with non-dysfunctional BAV, initial BAV function and degree of aorta dilatation might be important for progression and outcomes. Patients without any dysfunction or aortopathy tend to maintain good structure and function for 6 years.
The Effect of Nebivolol on Office Blood Pressure of Blacks Residing in Sub-Saharan Africa (A Pilot Study)
Authors: Ojji Dike , Ale Boni Maxime , Shedul Lamkur , Umuerri Ejiroghene , Ejim Emmanuel , Alikor Chizindu , Agunyenwa Charles , Njideofor Uche , Eze Helen , Ansa Victor 
Published: January 2021

Introduction: There is substantial clinical evidence that monotherapy with beta-blockers are less effective in reducing blood pressure among hypertensive Black patients compared to Whites. The highly selective beta-1 agents like nebivolol and bisoprolol have, however, been reported to be effective in reducing blood pressure in African Americans. However, results in African Americans cannot be extrapolated to native Africans because of genetic admixture and gene-environment interaction. There is, therefore, the need for us to generate data that are applicable to Africans residing in sub-Saharan Africa. We therefore decided to evaluate the efficacy and tolerability of highly selective beta-1 agent nebivolol in hypertensive Black patients residing in sub-Saharan Africa.Materials and Methods: The nebivolol study was a multicenter, prospective, observational program among hypertensive patients with 4- and 8-week follow up which was conducted in 5 cities in Nigeria of Abuja, Calabar, Enugu, Oghara, and Port Harcourt. Dosages of nebivolol used in keeping with local prescribing information were 5 and 10 mg once daily each. The effectiveness of treatment was assessed by change from baseline in mean office systolic and diastolic blood pressures, and the proportion of patients achieving the therapeutic goal of &lt;140/90 mmHg. Safety and tolerability of this medication were also assessed.Results: We report the results of the 140 patients studied. The mean age and body mass index were 46.9 ± 7.3 years and 22.3 ± 5.8 kg/m2, respectively, and 57.1% were female. Nebivolol reduced SBP and DBP by 7.6 and 6.6 mmHg, respectively, in 4 weeks, and by 11.1 and 8.0 mm Hg, respectively, in 8 weeks. Blood pressure control was achieved in 54.8% of the patients in 4 weeks and increased to 60.4% in 8 weeks. There was no change in metabolic profile between randomization and at 8 weeks, and erectile dysfunction occurred in 1.3% of the study population.Conclusions: Nebivolol 5 and 10 mg appear efficacious in Nigerian Africans with no negative metabolic effect and minimal side effect profile.Clinical Trial Registration:www.ClinicalTrials.gov, Study Identification: NCT 03598673.
Lymphocyte and NK Cell Counts Can Predict Sepsis-Associated Delirium in Elderly Patients
Authors: Li Dongkai , Zhang Jiahui , Bai Guangxu , Chen Jianwei , Cheng Wei , Cui Na 
Published: January 2021

Background: Sepsis-associated delirium (SAD) is prevalent in elderly patients and is recognized as brain dysfunction associated with increased inflammatory response in the central nervous system during sepsis. Neuroinflammation was demonstrated to be part of its mechanism and we aimed to validate the role of immunity imbalance in a combined retrospective and prospective cohort study.Methods: We performed a retrospective study analyzing the association between SAD and lymphocyte counts in the peripheral blood, alongside a prospective trial evaluating the quantitative changes in lymphocyte subsets and their predictive value for early diagnosis of SAD.Results: In the retrospective study, among 1,010 enrolled adult patients (age ≥65 years), 297 patients were diagnosed with delirium during intensive care unit (ICU) stay and lymphocyte counts at ICU admission in the SAD group were significantly higher than in non-delirious counterparts (1.09 ± 0.32 vs. 0.82 ± 0.24, respectively, p = 0.001). In the prospective study, lymphocyte counts [0.83 (0.56, 1.15) vs. 0.72 (0.40, 1.06) × 109/L, p = 0.020] and natural killer (NK) cell counts [96 (68, 118) vs. 56 (26, 92) cells/μl, p = 0.024] were significantly higher in the SAD group. The area under the curve value of NK cell count was 0.895 [95% confidence interval (CI): 0.857, 0.933] and of lymphocyte count was 0.728 (95% CI: 0.662, 0.795). An NK cell count cut-off value of 87 cells/ml in septic patients at ICU admission was predictive of delirium with a sensitivity of 80.2% and specificity of 80.8%.Conclusions: We found that lymphocyte and NK cell counts were significantly higher in senior patients with SAD and that NK cell count may be valuable for the prediction of SAD within elderly patient cohorts.
Correlated Sensory and Sympathetic Innervation Between the Acupoint BL23 and Kidney in the Rat
Authors: Zhang Zhiyun , Xu Dongsheng , Wang Jia , Cui Jingjing , Wu Shuang , Zou Ling , Shen Yi , Jing Xianghong , Bai Wanzhu 
Published: January 2021

Objective: To investigate the sensory and sympathetic innervations associated with both acupoint “Shenshu” (BL23) and kidney in the rat for insight into the neuronal correlation between the Back-Shu Point and its corresponding visceral organ.Methods: The BL23 and kidney were selected as the representative acupoint and visceral organ in this study, in which their local nerve fibers were examined by using double fluorescent immunohistochemistry with calcitonin gene-related peptide (CGRP) and tyrosine hydroxylase (TH). Meanwhile, their neuronal correlation in the dorsal root ganglia (DRGs), spinal cord, and sympathetic (paravertebral) chain were investigated using a double fluorescent neural tracing technique with Alexa Fluor 488 and 594 conjugates with cholera toxin subunit B (AF488/594-CTB).Results: The local tissue of acupoint BL23 and the fibrous capsule of kidney distributed abundantly with CGRP- and TH-positive nerve fibers, corresponding to their sensory and sympathetic innervation. On the other hand, the sensory neurons associated with acupoint BL23 and kidney were labeled with AF488/594-CTB and distributed from thoracic (T) 11 to lumbar (L) 3 DRGs and from T10 to L2 DRGs, respectively, in which some of them in T12-T13 DRGs were simultaneously labeled with both AF488/594-CTB. Also, postganglionic neurons associated with both acupoint BL23 and kidney were found in the sympathetic chain at the same spinal segments but separately labeled with AF488-CTB and AF594-CTB.Conclusion: Our study demonstrates the neural characteristics of the acupoint BL23 and kidney in the rat from the perspective of neurochemistry and neural pathways, providing an example for understanding the neuronal correlation between the Back-Shu Points and their corresponding visceral organs. These results suggest that the stimulation of the Back-Shu Points may regulate the activities of the target-organs via the periphery sensory and sympathetic pathways.
Hesperidin Interacts With CREB-BDNF Signaling Pathway to Suppress Pentylenetetrazole-Induced Convulsions in Zebrafish
Authors: Sharma Pallavi , Kumari Savita , Sharma Jatin , Purohit Rituraj , Singh Damanpreet 
Published: January 2021

Hesperidin (3,5,7-trihydroxyflavanone 7-rhamnoglucoside) is a β-7-rutinoside of hesperetin (4′-methoxy-3′,5,7-trihydroxyflavanone), abundantly found in citrus fruits and known to interact with various cellular pathways to show a variety of pharmacological effects. The present study was envisaged to understand the anticonvulsant effect of hesperidin in a zebrafish model of pentylenetetrazole (PTZ)-induced convulsions, with the support of in silico docking. Healthy zebrafish larvae were preincubated with hesperidin (1, 5, and 10 µM) for 1 h, before PTZ exposure. Hesperidin treatment significantly increased the seizure latency and minimized PTZ-induced hyperactive responses. A significant reduction in c-fos expression further supported the suppression of neuronal excitation following hesperidin incubation in the larvae exposed to PTZ. The treatment also modulated larval bdnf expression and reduced the expression of il-10. The results of in vivo studies were further supported by in silico docking analysis, which showed the affinity of hesperidin for the N-methyl-d-aspartate receptor, the gamma-aminobutyric acid receptor, Interleukin 10 and the TrkB receptor of brain-derived neurotrophic factor. The results concluded that hesperidin suppresses PTZ-mediated seizure in zebrafish larvae through interaction with the central CREB–BDNF pathway.
Characterization of Formononetin Sulfonation in SULT1A3 Overexpressing HKE293 Cells: Involvement of Multidrug Resistance-Associated Protein 4 in Excretion of Sulfate
Authors: Liu Fanye , Pei Shuhua , Li Wenqi , Wang Xiao , Liang Chao , Yang Ruohan , Zhang Zhansheng , Yao Xin , Fang Dong , Xie Songqiang , Sun Hua 
Published: January 2021

Formononetin is one of the main active compounds of traditional Chinese herbal medicine Astragalus membranaceus. However, disposition of formononetin via sulfonation pathway remains undefined. Here, expression-activity correlation was performed to identify the contributing of SULT1A3 to formononetin metabolism. Then the sulfonation of formononetin and excretion of its sulfate were investigated in SULT1A3 overexpressing human embryonic kidney 293 cells (or HKE-SULT1A3 cells) with significant expression of breast cancer resistance protein (BCRP) and multidrug resistance-associated protein 4 (MRP4). As a result, formononetin sulfonation was significantly correlated with SULT1A3 protein levels (r = 0.728; p &lt; 0.05) in a bank of individual human intestine S9 fractions (n = 9). HEK-SULT1A3 cells catalyzed formononetin formation of a monosulfate metabolite. Sulfate formation of formononetin in HEK-SULT1A3 cell lysate followed the Michaelis-Menten kinetics (Vmax = 13.94 pmol/min/mg and Km = 6.17 μM). Reduced activity of MRP4 by MK-571 caused significant decrease in the excretion rate (79.1%–94.6%) and efflux clearance (85.3%–98.0%) of formononetin sulfate, whereas the BCRP specific inhibitor Ko143 had no effect. Furthermore, silencing of MRP4 led to obvious decrease in sulfate excretion rates (&gt;32.8%) and efflux clearance (&gt;50.6%). It was worth noting that the fraction of dose metabolized (fmet), an indicator of the extent of drug sulfonation, was also decreased (maximal 26.7%) with the knockdown of MRP4. In conclusion, SULT1A3 was of great significance in determining sulfonation of formononetin. HEK-SULT1A3 cells catalyzed formononetin formation of a monosulfate. MRP4 mainly contributed to cellular excretion of formononetin sulfate and further mediated the intracellular sulfonation of formononetin.
Transsystémisme et droit commun. Une clé du droit occidental
Authors: Zenati-Castaing Frédéric 
Published: January 2021

Le transsystémisme est une méthode d’enseignement simultané et comparé de la
Common law et du droit romaniste mise au point par l’Université Mc Gill de Montréal. Cette méthode a une signification historique, car elle établit, pour la première fois, une communication scientifique entre les deux traditions juridiques de l’Occident, communication qui fait émerger leur souche commune. C’est une approche originale du droit commun, d’inspiration anglaise : elle ne consiste pas à unifier mais à mettre au jour ce qui est commun, tout en respectant ce qui est différent, montrant à la fois l’unité et la diversité du droit occidental. L’article met l’accent sur l’opportunité d’une archéologie des sources romaines communes dans les développements futurs de cette méthode. Il met aussi incidemment en évidence les racines communes du ius commune et de la Common law.
Uji Efek Antiinflamasi Infusa Daun Bayam Merah (Amaranthus tricolor L.) Terhadap Tikus Putih (Rattus norvegicus) Yang Diinduksi Karagenan
Authors: Isrul Muhammad , Dewi Citra , Wahdini Vivin 
Published: January 2021

Daun bayam merah (Amaranthus tricolor L.) merupakan tumbuhan yang biasa ditanam untuk dikonsumsi daunnya karena memiliki banyak manfaat dan kandungannya bagi kesehatan tubuh dan daun bayam merah (Amarantus tricolor L.) mengandung komponen antioksidan. Penelitian ini bertujuan untuk mengetahui kandungan metabolit sekunder yang terkandung dalam infusa daun bayam merah (Amarantus tricolor L.) dan untuk mengetahui konsentrasi infusa daun bayam merah (Amarantus tricolor L.) yang dapat menghasilkan efek antiinflamasi. Penelitian ini menggunakan metode induksi karagenan sebagai zat iritannya. Infusa daun bayam merah (Amaranthus tricolor L.) dibuat dalam berbagai variasi konsentrasi 10%, 15% dan 25% yang diberikan secara oral pada tikus putih. Natrium diklofenak digunakan sebagai kontrol positif, Na CMC digunakan sebagai kontrol negatif. Pengukuran dilakukan setiap 30 menit selama 180 menit setelah induksi karagen 1% 0,2 ml. Analisis data dilakukan dengan menggunakan One-Way ANOVA dan dilanjutkan dengan uji LSD. Daun bayam merah (Amaranthus tricolor L.) memiliki metabolit sekunder yaitu, alkaloid, flavonoid, saponin, quinon, tanin, dan steroid. Infusa daun bayam merah (Amaranthus tricolor L.) efektif sebagai antiiflamasi pada konsentrasi 10% dengan nilai P signifikan yaitu 0,778 > 0,05 dan konsentrasi 25% dengan nilai P signifikan yaitu 0,725 > 0,05. Konsentrasi tersebut tidak berbeda signifikan dengan kontrol positif Natrium diklofenak. Dari hasil penelitian ini dapat ditarik kesimpulan infusa daun bayam merah (Amaranthus tricolor L.) dapat menghambat pembentukan udema.
Jahe Peningkat Sistem Imun Tubuh di Era Pandemi Covid- 19 di Kelurahan Kadia Kota Kendari
Authors: Nurlila Ratna Umi , La Fua Jumarddin 
Published: January 2021

Covid-19 adalah penyakit baru yang telah menjadi pandemic, penyakit ini harus diwaspadai karena penularan yang relatif cepat, memiliki tingkat mortalitas yang tidak dapat diabaikan. Hingga saat ini kasus penderita virus covid 19 terus mengalami peningkatan, kasus di Sulawesi tengara mencapai 3.568 kasus terkonfirmasi positif, kasus sembuh mencapai 2.348 orang dan kasus meningal 66 orang. (Media Indonesia dalam covid 19, 2020). Kasus ini di duga akan terus mengalami peningkatan jika kesadaran masyarakat dalam pematuhan protokol kesehatan tidak dilaksanakan. Disamping itu perulu upaya peningkatan sistem imun tubu mengingat virus dapat masuk kedalam tubuh manusia pada saat imun mengalami penurunan. Sistem imun tubuh penting untuk di jaga dalam era covid 19 seperti saat ini, salah satu sumberdaya alam yang cukup melimpah di sultra dengan harga yang murah dan memiliki kandungan antioksidan yang cukup tinggi adalah rimpang jahe, rimpang jahe ini banyak di jumpai di pasar tradisional dan petani di samping itu di dalam rimpang jahe banyak sekali kandungan senyawa aktif yang menyehatkan bagi tubuh, di tengah keterbatasan suplai produksi vit C dan sulit terjangkaunya bagi masyarakat menengah ke bawah rimpang jahe ini sangat membantu masyarakat dalam meningkatkan sistem imun. Kegiatan pengabdian masyarakat ini dilakasanakan di kelurahan kadia, kecamatan kadia, kota kendari,mengingat sejak juni hingga oktober terjadi peningkatan jumlah kasus positif covid di daerah ini, maka sangat perlu memberikan edukasi kepada masyarakat serta mengajak masayarakat khususnya khususnya di tempat pengabdian ini untuk terus patuh terhadap protocol ksehatan dan menjaga sistem imun tubuh dengan mengkonsumsi jahe dengan beberapa olahan, serta melakukan penanamn jahe pada pekarangan rumah sebagai sarana penyediaan jahe untuk keluarga
La Villemarqué and the Arthurian Songs in the Barzaz-Breiz
Authors: Péron Goulven 
Published: January 2021

Le vicomte Théodore Hersart de La Villemarqué a longtemps été accusé d’avoir inventé de toutes pièces les chansons arthuriennes qui apparaissent dans son recueil de chants populaires de la Bretagne, le Barzaz-Breiz. Cet article tente de mettre en évidence les restaurations effectuées par le collecteur sur ces chants arthuriens et de montrer le rôle joué par certains pourvoyeurs de « chansons nouvelles ».
Mutation and Creation of the Human Body, or the Figures of the Matrix
Authors: Chifflet Stéphanie 
Published: January 2021

Dans cet article, nous développons l’idée que les genèses du posthumain et du clone sont encore tributaires d’un imaginaire de la matrice. L’antre souterrain, le cocon, l’œuf, le ventre maternel ne demeurent-ils pas les référents majeurs (les images primordiales) pour penser la création et la naissance, même lorsqu’elles sont artificielles ? Les récits anthropotechniques, nouvelles anthropogonies, mettent ainsi en scène une nouvelle matrice — actualisée.