bluuebunny/crossref_metadata_2025_split huggingface dataset:
Speaking Truth to Power: Mental Health Service Users’ Experiences of Participation in their Diagnosis and Treatment
Authors: Kirwan Gloria 
Published: October 2021

In a qualitative study, long-term mental health service users shared their views on the concept of ‘participation’ as shaped by their personal histories of contact with mental health services in Ireland. Adopting a narrative methodology, the study participants were asked to draw on their experiences with mental health services to illustrate their general views on participation by service users in mental health care contexts.In this study, the research participants recounted positive experiences of participation in which their expressed views regarding their symptoms and treatment needs were incorporated into the service responses they received. The data revealed that service users perceived open and inclusive communication by service providers as an important factor in optimising their ability to participate in help-seeking, diagnosis and treatment plans. However, the study also illuminated the chilling effect on participation when service users’ views were not heeded or acknowledged by service providers. The findings highlight how the failure to include service users’ insights can negatively encroach on service user participation. The service user narratives collected in this study exposed the often uneasy juxtaposition of the service user’s personally held ‘truth’ regarding their lived experience of mental distress versus the powerful system of expert diagnosis and treatment. This article focuses on reporting selective findings from the study regarding participation in the contexts of help-seeking, diagnosis and treatment decisions.
Örgütsel Sağlığın Lider-Üye Etkileşimi ve Whistleblowing Üzerindeki Etkisi: Otel İşletmelerinde Bir Alan Araştırması
Authors: ÇİÇEKLİOĞLU Hüseyin , KALE Anıl 
Published: October 2021

Amaç: Bu araştırmanın amacı; otel işletmelerinde çalışan bireylerin örgütsel sağlık algılarının whistleblowing ve lider üye etkileşimi düzeyleri üzerindeki etkisini tespit etmektir. Bu amacın yanı sıra; araştırma değişkenleri arasındaki ilişkilerin yönünün ve düzeyinin de belirlenmesi amaçlanmıştır.
Tasarım/Yöntem: Bu araştırmada Doğu Akdeniz bölgesinde yer alan bir ildeki beş yıldızlı iki otelde görev yapan çalışanlar üzerinde kolayda örnekleme yöntemiyle belirlenen 128 çalışana anket uygulanmıştır. Elde edilen veriler SPSS aracılığıyla analize tabi tutulmuştur.
Bulgular: Araştırma sonuçlarına göre; örgütsel sağlığın whistleblowing ve lider üye etkileşimini pozitif yönde etkilediği tespit edilmiştir. Örgütsel sağlık düzeyi arttıkça whistleblowing ve lider üye etkileşim düzeyleri artmaktadır. Bununla birlikte lider üye etkileşim düzeyi arttıkça whistleblowing davranışlarının arttığı tespit edilmiştir.
Sınırlılıklar: Bu araştırma sonucunda ortaya konulan sonuçlar; çözülmesi amaçlanan problem, ele alınan değişkenler, kullanılan yöntem, belirlenen örneklem ve başvurulan istatistiksel analiz teknikleri kapsamında üretilmiştir. Dolayısıyla bir dizi sınırlılık mevcuttur. Alan araştırması kapsamında toplanan veriler kesitsel bir özellik göstermekte ve Doğu Akdeniz bölgesinde yer alan bir ildeki beş yıldızlı iki otelde görev yapan çalışanlardan oluşmaktadır.
Özgünlük/Değer: Araştırma kapsamında ele alınan değişkenlerin ilgili alan yazında gri bir alan bırakması, üç değişkenin bir arada ele alınmamış olması, alan yazındaki boşluğu doldurmaya katkı sağlaması adına önem ve özgünlük arz etmektedir.
Standardized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA
Authors: Natarajan Aravind , Han Alvin , Zlitni Soumaya , Brooks Erin F. , Vance Summer E. , Wolfe Marlene , Singh Upinder , Jagannathan Prasanna , Pinsky Benjamin A. , Boehm Alexandria , Bhatt Ami S. 
Published: October 2021

Abstract
COVID-19 patients shed SARS-CoV-2 RNA in stool, sometimes well after their respiratory infection has cleared. In our benchmarking study, we recommend a standardized protocol for the preservation, extraction and detection of viral RNA from stool. This protocol includes a preservative, viral RNA extraction steps, and PCR-based quantification methods to maximize yield and detection of SARS-CoV-2 RNA. Our protocol takes advantage of commercially available reagents and equipment to maximize ease of access and consistency across studies. Additionally, we apply an attenuated bovine coronavirus vaccine as a spike-in control, and synthetic RNA standards to improve standardization and reliability of the assay. While we recommend both ddPCR and RT-qPCR-based assays, we acknowledge that ddPCR may be prohibitively expensive due to the necessity of specialized equipment and reagents. This protocol was developed with a focus on SARS-CoV-2 RNA, but may apply to other coronaviruses as well. We estimate that this protocol takes between 6 to 8 hours total to quantify the viral RNA load in a fecal sample.
Connectivity Index of M-polar Fuzzy Graph with Application
Authors: Mandal Sonia , Pal Madhumangal 
Published: October 2021

Abstract
This paper brings in connectivity index of a m -polar fuzzy graph ( m PFG) with its boundedness. We investigate how the connectivity index of a m PFG changes when a vertex or an edge is deleted. Some special types of vertices include m -polar fuzzy connectivity enhancing node( m PFCEN), m -polar fuzzy connectivity neutral node ( m PFCNN), m -polar fuzzy connectivity reducing node ( m PFCRN) with their properties are discussed.
Examining Diffusion and Convergence Processes of Three Road Safety Policies, 1964-2015
Authors: Nazif-Munoz Jose , Berg Axel van den , Quesnel-Vallée Amélie 
Published: October 2021

Abstract
Global convergence of public policies has been regarded as a defining feature of the late twentieth century. This study explores the generalizability of this thesis for three road safety measures: i) road safety agencies; ii) child restraint laws; and iii) mandatory use of daytime running lights. We analyze cross-national longitudinal data using survival analysis for the years 1964-2015 in 181 countries. Our first main finding is that only child restraint laws have globally converged; in contrast, the other two policies exhibit a fractured global convergence process, likely as the result of competing international and national forces. This finding may reflect the lack of necessary conditions, at the regional and national levels, required to accelerate the spread of policies globally, adding further nuance to the global convergence thesis. A second finding is that mechanisms of policy adoption, such as imitation/learning and competition, rather than coercion, explain more consistently global and regional convergence outcomes in the road safety realm. This finding reinforces the idea of specific elective affinities, when explaining why the diffusion of policies may or not result in convergence. Lastly, by recognizing fractured convergence processes, our results call for revisiting the global convergence thesis and reintegrating more consistently regional analyses into policy diffusion and convergence studies.
Improved Fuzzy Cognitive Maps for Gene Regulatory Networks Inference Based on Time Series Data
Authors: Emadi Marzieh , Boroujeni Farsad Zamani , Pirgazi jamshid 
Published: October 2021

Abstract
Recently with the advancement of high-throughput sequencing, gene regulatory network inference has turned into an interesting subject in bioinformatics and system biology. But there are many challenges in the field such as noisy data, uncertainty, time-series data with numerous gene numbers and low data, time complexity and so on. In recent years, many research works have been conducted to tackle these challenges, resulting in different methods in gene regulatory networks inference. A number of models have been used in modeling of the gene regulatory networks including Boolean networks, Bayesian networks, Markov model, relational networks, state space model, differential equations model, artificial neural networks and so on. In this paper, the fuzzy cognitive maps are used to model gene regulatory networks because of their dynamic nature and learning capabilities for handling non-linearity and inherent uncertainty. Fuzzy cognitive maps belong to the family of recurrent networks and are well-suited for gene regulatory networks. In this research study, the Kalman filtered compressed sensing is used to infer the fuzzy cognitive map for the gene regulatory networks. This approach, using the advantages of compressed sensing and Kalman filters, allows robustness to noise and learning of sparse gene regulatory networks from data with high gene number and low samples. In the proposed method, stream data and previous knowledge can be used in the inference process. Furthermore, compressed sensing finds likely edges and Kalman filter estimates their weights. The proposed approach uses a novel method to decrease the noise of data. The proposed method is compared to CSFCM, LASSOFCM, KFRegular, ABC, RCGA, ICLA, and CMI2NI. The results show that the proposed approach is superior to the other approaches in fuzzy cognitive maps learning. This behavior is related to the stability against noise and offers a proper balance between data error and network structure.
The small and large intestine contain transcriptionally related mesenchymal stromal cell subsets that derive from embryonic Gli1+ mesothelial cells
Authors: Pærregaard Simone , Schussek Sophie , Wulff Line , Niss Kristoffer , Mörbe Urs , Jendholm Johan , Wendland Kerstin , Andrusaite Anna , Brulois Kevin , Nibbs Robert , Sitnik Katarzyna , Mowat Allan , Butcher Eugene , Brunak Søren , Agace William 
Published: October 2021

Abstract
Intestinal fibroblasts (FB) play essential roles in intestinal homeostasis. Here we show that the small and large intestinal lamina propria (LP) contain similar FB subsets that locate in specific anatomical niches and express distinct arrays of epithelial support genes. However, there were tissue specific differences in the transcriptional profile of intestinal FB subsets in the two sites. All adult intestinal LP mesenchymal stromal cells (MSC), including FB, smooth muscle cells (SMC) and pericytes derive from Gli1-expressing embryonic precursors which we identify as mesothelial cells. Trajectory analysis suggested that adult SMC and FB derive from distinct embryonic intermediates, and that adult FB subsets develop in a linear trajectory from CD81+ FB. Finally, we show that colonic subepithelial PDGFRαhi FB comprise several functionally and anatomically distinct populations that originate from an Fgfr2-expressing FB intermediate. Collectively our results provide novel insights into MSC diversity, location, function and ontogeny, with implications for our understanding of intestinal development, homeostasis and disease.
The Neutrophil Percentage-to-Albumin Ratio is Associated with All-Cause Mortality in Critically Ill Patients with Acute Myocardial Infarction
Authors: Lin Ya , Lin Yanhan , Yue Juanqing , Zou Qianqian 
Published: October 2021

Abstract
Aim
In this study, we evaluated the utility of neutrophil percentage-to-albumin ratio (NPAR) in predicting in critically ill patients with acute myocardial infarction (AMI).
Methods
the information of patients were collected from Medical Information Mart for Intensive Care III (MIMIC III) database. Admission NPAR was calculated as neutrophil percentage divided by serum albumin. The endpoints of this study were 30-day, 90-day, 180-day, and 365-day all-cause mortality. Cox proportional hazards models and subgroup analyses were used to determine the relationship between admission NPAR and these endpoints.
Results
798 critically ill patients with AMI were enrolled in. After adjustments for age, race and gender, higher admission NPAR was associated with increased risk of 30-day, 90-day, 180-day, and 365-day all-cause mortality in critically ill patients with AMI. And after adjusting for possible confounding variables, two different trends have emerged. Stratified by tertiles, high admission NPAR was independently associated with 180-day and 365-day all-cause mortality in critically ill patients with AMI (tertile 3 vs. tertile 1: adjusted HR, 95%CI: 1.71,1.10-2.66, p<0.05;1.66,1.10-2.51, p<0.05). In other hand, stratified by quartiles, highest admission NPAR levels were independently associated with 90-day, 180-day and 365-day all-cause mortality (quartile 4 vs. quartile 1: adjusted HR, 95% CI: 2.36,1.32-4.23, p<0.05; 2.58,1.49-4.47, p<0.05; 2.61,1.56-4.37, p<0.05). ROC test showed that admission NPAR had a moderate ability to predict all-cause mortality of critically ill patients with AMI. No obvious interaction was found by subgroup analysis in most subgroups.
Conclusions
admission NPAR was an independent predictor for 180-day and 365-day all-cause mortality in critically ill patients with AMI.
Mechanism and Modeling of Human Disease-associated Near-exon Intronic Variants That Perturb RNA Splicing
Authors: Lin Chien-Ling , Chiang Hung-Lun , Chen Yi-Ting , Su Jia-Ying , Lin Hsin-Nan , Yu Chen-Hsin , Hung Yu-Jen , Wang Yun-Lin , Huang Yen-Tsung 
Published: October 2021

Abstract
The authors have requested that this preprint be removed from Research Square.
Sex-Related Differences in Visuomotor Skill Recovery Following Concussion in Working-Aged Adults
Authors: Smeha Nicole , Kalkat Ravneet , Sergio Lauren E. , Hynes Loriann M. 
Published: October 2021

Abstract
Background: The ability to perform visually-guided motor tasks requires the transformation of visual information into programmed motor outputs. When the guiding visual information does not align spatially with the motor output, the brain processes rules to integrate somatosensory information into an appropriate motor response. Performance on such rule-based, “cognitive-motor integration” tasks is affected in concussion. Here, we investigate the relationship between visuomotor skill performance, concussion history, and sex during the course of a post-concussion management program. Methods: A total of 43 participants, divided into 3 groups based on their concussion history, completed a recovery program over the course of 4 weeks. Prior to, mid-way, and following the program, all participants were tested on their visuomotor skills. Results: We observed an overall change in visuomotor behaviour in all groups, as participants completed the tasks faster and more accurately. Specifically, we observed significant visuomotor skill improvement between the first and final sessions in participants with a concussion history compared to no-concussion-history controls. Notably, we observed a stronger recovery of these skills in females. Conclusions: Our findings indicate that (1) concussion impairs visuomotor skill performance, (2) the performance of complex, rule-based tasks can be improved over the course of a recovery program, and (3) stronger recovery in females suggests sex-related differences in the brain networks controlling skilled performance, and the effect of injury on these networks.
Effects of SiC On the Microstructure, Densification, Hardness and Wear Performance of TiB2 Ceramic Matrix Composite Consolidated Via Spark Plasma Sintering
Authors: Oguntuyi Samson Dare , Shongwe Mxolisi Brendon , Tshabalala Lerato , Johnson Oluwagbenga T. , Malatji Nicholus 
Published: October 2021

Abstract
Monolithic TiB2 are known to have a good combination of densification and hardness which are sometimes useful but limited in application. However, their usage in service at elevated temperatures such as in power thermal plants, cutting tools, tribological purposes (cutting tools, mechanical seals, blast nozzles, and wheel dressing tools), etc leads to catastrophic failure. Hence, the introduction of sintering additives in the TiB2 matrix has a high influence on the improvement of its sinterability, and properties (fracture toughness, wear resistance etc.,) of the resulting composite needed to meets the requirement for various industrial applications. In this study, the influence of SiC as sintering additives on the microstructure, densification, hardness and wear performance of TiB2 ceramic was observed. Hence, TiB2, TiB2-10wt%SiC and TiB2-20wt%SiC were sintered at 1850 oC for 10 minutes under 50 MPa. The impacts of SiC on the TiB2 were observed to improve the microstructure correspondingly improving densification and mechanical properties, most especially with the composites with 20wt% SiC. Combined excellent densification, hardness and fracture toughness of 99.5%, 25.5 GPa, 4.5 MPa.m1/2 were achieved respectively for TiB2-20wt%SiC. Diverse in-situ phase and microstructural alterations were detected in the sintered composites, and it was discovered that the in-situ phase of TiC serves as the contributing factor to the enhanced features of the composites. Moreover, the coefficient of friction and wear performance outcomes of the synthesized composites described a decrease in the coefficient with an enhanced wear resistance via the increasing SiC particulate, although the application of the load from 10 N-20 N increased the wear rates.
Comparison of the Effectiveness of High-Flow Nasal Oxygen vs. Standard Facemask Oxygenation for pre- and apneic oxygenation during Anesthesia Induction: A Systematic Review and Meta-analysis
Authors: Song Jian-li , Sun Yan , Shi Yu-bo , Liu Xiao-ying , Su Zhen-bo 
Published: October 2021

Abstract
BackgroundIn recent years, high flow nasal oxygen(HFNO) has been widely used in clinic, especially in perioperative period.Many studies have discussed the role of HFNO in pre- and apneic oxygenation, but their results are controversial.Our study aimed to examine the effectiveness of HFNO in pre- and apneic oxygenation by a meta-analysis ofRCTs.MethodsEMBASE, PUBMED, and COCHRANE LIBRARY databases were searched from inception to July 2021 for relevantrandomized controlled trails(RCTs) on the effectiveness of HFNO versus standard facemask ventilation(FMV) inpre- and apenic oxygenation. Studies involving one of the following six indicators: (1)Arterial oxygen partialpressure(PaO2), (2)End expiratory oxygen concentration(EtO2), (3)Safe apnoea time, (4)Minimum pulse oxygensaturation(SpO2min), (5)Oxygenation(O2) desaturation, (6)End expiratory carbon dioxide(EtCO2) or Arterial carbondioxide partial pressure(PaCO2) were included. We select random effect model or fixed effect model for analysisaccording to the heterogeneity of the article, and express it as the mean difference(MD) or risk ratio(RR) with aconfidence interval of 95%(95%CI). We conducted a risk assessment of bias for eligible studies and assessed theoverall quality of evidence for each outcome.Results14 RCTs and 1012 participants were finally included. We found the PaO2 was higher in HFNO group than FMVgroup with a MD(95% CI) of 57.38 mmHg(25.65 to 89.10; p=0.0004) after preoxygenation and the safe apnoeatime was significantly longer with a MD(95% CI) of 86.93 seconds(44.35 to 129.51; p<0.0001) during anesthesiainduction. There were no significant statistical difference in the minimum O2 saturation, CO2 accumulation, endexpiratory oxygen concentration and O2 desaturation rate during anesthesia induction between the two groups.ConclusionsThis systematic review and meta-analysis suggests that HFNO should be considered as an airway managementtool for patients with high-risk hypoxemia or difficult airway during anesthesia induction. Compared with FMV,continuous use of HFNO during anesthesia induction can significantly improve oxygenation and prolong safeapnoea time in surgical patients.
Nonlinear response of gear system based on a novel backlash model with coupling dynamic change and surface topography
Authors: Yu Xin , Sun Yunyun , Li Hongguang , Wu Shijing 
Published: October 2021

Abstract
Backlash is one of main nonlinear internal excitation factors in gear transmission system and therefore has been widely concerned. Most existing models of backlash are based on a random constant, which ignore the dynamic characteristics of backlash itself and the effects of surface topography. To model the backlash precisely, in this paper, the constant part of backlash is revised through average height of all asperities in contact region related to surface roughness by fractal method. Simultaneously, the dynamic part is modeled considering the displacement of gear center motion that comes from shaft deformation in coupling dynamic meshing. A complete backlash model consisting of the two parts is established subsequently and a corresponding close-loop algorithm is proposed to solve system dynamics by coupling mesh stiffness and time varying pressure angle. Through time history charts, phase portraits and Poincare mapping as well as frequency spectrograms, calculation results clearly demonstrate the comprehensive effects of dynamic backlash on the nonlinear dynamics involving vibration amplitude, frequency and chaotic characteristics of a spur gear pair. The effects of surface topography on backlash and system nonlinear response including vibration amplitude and chaotic features are also analyzed, therefore dynamic backlash and surface topography are important factors that cannot be ignored in gear issue. The comparison with experimental data as well as other previous models is conducted to verify the superiority of proposed model.
Differences in RNA polymerase II complexes and their interactions with surrounding chromatin on human and cytomegalovirus genomes
Authors: Spector Benjamin , Parida Mrutyunjaya , Ball Christopher , Li Ming , Meier Jeffrey , Luse Donal S. , Price David 
Published: October 2021

Abstract
Interactions of the RNA polymerase II (Pol II) preinitiation complex (PIC) and paused early elongation complexes with the first downstream (+1) nucleosome are thought to be functionally important. However, current methods are limited for investigating these relationships, both for cellular chromatin and the human cytomegalovirus (HCMV) genome. Digestion with human DNA fragmentation factor (DFF) before immunoprecipitation (DFF-ChIP) precisely revealed both similarities and major differences in PICs driven by TBP on the host genome in comparison with PICs driven by TBP or the viral-specific, late initiation factor UL87 on the viral genome. Host PICs and paused Pol II complexes are frequently found in contact with the +1 nucleosome and paused Pol II can also be found in a complex involved in the initial invasion of the +1 nucleosome. In contrast, viral transcription complexes have very limited nucleosomal interactions, reflecting a relative lack of chromatinization of transcriptionally active regions of HCMV genomes.
Metagenomics-informed soil biogeochemical models projected less carbon loss in tropical soils in response to climate warming
Authors: song Yang , Yao Qiuming , Yao Xiaojuan , Wright Joseph , Wang Gangsheng , Hazen Terry , Turner Benjamin , Tfaily Malak , Paša-Tolic Ljiljana , Johnston Eric , Kim Minjae , Konstantinos Konstantinos , Pan Chongle , Mayes Melanie 
Published: October 2021

Abstract
A major challenge of quantifying feedback between microbial communities and climate is the vast diversity of microbial communities and the intricacy of soil biogeochemical processes they mediate. We overcome this challenge by simplifying the representation of diverse enzyme functions from metagenomics data. We developed a dynamic allocation scheme for enzyme functional classes (EFCs) based on the premise that microbial communities act to maximize acquisition of limiting resources while minimizing energy expenditure for acquiring unlimited resources. We incorporated this scheme into a biogeochemical model to explicitly represent microbial functional diversity and simulate responses of microbially-mediated soil biogeochemical processes to varying environmental and nutrient conditions. Representing microbial functional diversity and environmental acclimation improved predictions of the stoichiometry of microbial biomass and mitigated the sensitivity of soil organic carbon to warming in nutrient-deficient regions. Our results indicate the importance of microbial functional diversity and environmental acclimation for projecting climate feedbacks of nutrient-limited soils.