bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load
Authors: Reijm Sanne , Kissel Theresa , Stoeken-Rijsbergen Gerrie , Slot Linda M. , Wortel Corrie M. , van Dooren Hugo J. , Levarht Nivine E. W. , Kampstra Arieke S. B. , Derksen Veerle F. A. M. , Heer Pleuni Ooijevaar-de , Bang Holger , Drijfhout Jan W. , Trouw Leendert A. , Huizinga Tom W. J. , Rispens Theo , Scherer Hans U. , Toes René E. M. 
Published: September 2021

Abstract
Background
Anti-modified protein antibodies (AMPA) targeting citrullinated, acetylated and/or carbamylated self-antigens are hallmarks of rheumatoid arthritis (RA). Although AMPA-IgG cross-reactivity to multiple post-translational modifications (PTMs) is evident, it is unknown whether the first responding B cells, expressing IgM, display similar characteristics or if cross-reactivity is crucially dependent on somatic hypermutation (SHM). We now studied the reactivity of (germline) AMPA-IgM to further understand the breach of B cell tolerance and to identify if cross-reactivity depends on extensive SHM. Moreover, we investigated whether AMPA-IgM can efficiently recruit immune effector mechanisms.

Methods
Polyclonal AMPA-IgM were isolated from RA patients and assessed for cross-reactivity towards PTM antigens. AMPA-IgM B cell receptor sequences were obtained by single cell isolation using antigen-specific tetramers. Subsequently, pentameric monoclonal AMPA-IgM, their germline counterparts and monomeric IgG variants were generated. The antibodies were analysed on a panel of PTM antigens and tested for complement activation.

Results
Pentameric monoclonal and polyclonal AMPA-IgM displayed cross-reactivity to multiple antigens and different PTMs. PTM antigen recognition was still present, although reduced, after reverting the IgM into germline. Valency of AMPA-IgM was crucial for antigen recognition as PTM-reactivity significantly decreased when AMPA-IgM were expressed as IgG. Furthermore, AMPA-IgM was 15- to 30-fold more potent in complement-activation compared to AMPA-IgG.

Conclusions
We provide first evidence that AMPA-IgM are cross-reactive towards different PTMs, indicating that PTM (cross-)reactivity is not confined to IgG and does not necessarily depend on extensive somatic hypermutation. Moreover, our data indicate that a diverse set of PTM antigens could be involved in the initial tolerance breach in RA and suggest that AMPA-IgM can induce complement-activation and thereby inflammation.
Differential horizontal migration patterns of two male salmon sharks (Lamna ditropis) tagged in the Bering Sea
Authors: Garcia Sabrina , Tribuzio Cindy A. , Seitz Andrew C. , Courtney Michael B. , Nielsen Julie K. , Murphy Jim M. , Oxman Dion S. 
Published: September 2021

Abstract
Background
The salmon shark (Lamna ditropis) is a widely distributed apex predator in the North Pacific Ocean. Many salmon sharks from the eastern North Pacific, specifically Prince William Sound, Alaska, have been satellite tagged and tracked, but due to the sexual segregation present in salmon sharks, most of these tagged sharks were female. Consequently, little information exists regarding the migration patterns of male salmon sharks. To better understand the migration and distribution of this species, information on the male component of the population as well as from sharks outside of Prince William Sound, Alaska, is needed. In this study, we deployed satellite transmitters on two mature male salmon sharks caught in the Bering Sea.

Results
The two mature male salmon sharks tagged in the Bering Sea exhibited distinct migration patterns. The first male, tagged in August 2017, traveled to southern California where it remained from January to April after which it traveled north along the United States’ coast and returned to the Bering Sea in August 2018. The second male, tagged in September 2019, remained in the North Pacific between 38° N and 50° N before returning to the Bering Sea in July of year one and as of its last known location in year two. The straight-line distance traveled by the 2017 and 2019 sharks during their 12 and 22 months at liberty was 18,775 km and 27,100 km, respectively.

Conclusions
Before this study, our understanding of salmon shark migration was limited to female salmon sharks satellite tagged in the eastern North Pacific. The 2017 male salmon shark undertook a similar, but longer, north–south migration as tagged female sharks whereas the 2019 shark showed little overlap with previously tagged females. The different migration patterns between the two male sharks suggest distinct areas exist for foraging across the North Pacific. The return of both sharks to the Bering Sea suggests some fidelity to the region. Continued tagging efforts are necessary to understand the population structure of salmon sharks in the North Pacific. This tagging study highlights the importance of opportunistic efforts for obtaining information on species and sex with limited distribution data.
Preliminary results of Preserflo Microshunt versus Preserflo Microshunt and Ologen implantation
Authors: Vastardis Iraklis , Fili Sofia , Perdikakis Georgios , Kontopoulou Kalliopi , Balidis Miltos , Gatzioufas Zisis , Kohlhaas Markus 
Published: September 2021

Abstract
Purpose
To report preliminary 6-month results on the use of the Preserflo Microshunt implant with and without Ologen in 50 pseudophakic eyes with moderate to advanced primary open-angle glaucoma (POAG).

Methods
Fifty pseudophakic eyes underwent ab externo Preserflo Microshunt implantation. Data was gathered retrospectively and two groups were then created, group A with application of MMC 0.2 mg/ml and group B with MMC 0.2 mg/ml and Ologen collagen matrix (OCM) implantation. Absolute success was regarded as the percentage of eyes achieving: a) 5 ≤ intraocular pressure (IOP) ≤ 13 mmHg, b) 5 ≤ IOP ≤ 16 mmHg, and c) 5 ≤ IOP ≤ 21 mmHg without additional medication or surgery and qualified success was regarded as the percentage of eyes achieving a) IOP ≤ 13 mmHg, b) IOP ≤ 16 mmHg, and c) IOP ≤ 21 mmHg with or without medication. Evaluation was performed using a log-rank Kaplan-Meier test. A scatterplot analysis presented the treatment effect data of all eyes with a minimum of 20% IOP reduction per case. Failure was defined as requiring additional surgery, IOP greater than 21 mmHg with or without medication and failure to reach 20% IOP reduction.

Results
Mean postoperative IOP was significantly lower in both groups. IOP decreased by 49.06% in group A and by 53.01% in group B at 6 months (P < 0.88), respectively. Medication use was lower in both groups (Wilcoxon test, P < 0.001). The absolute and qualified success rates were not statistically significant between the groups (all P > 0.05). Cumulative IOP results per case were not statistically different in group A compared with group B. One revision surgery in group A (4% failure rate) and three in group B (12% failure rate) were performed.

Conclusions
Both groups showed equal results in terms of cumulative and mean IOP reduction, medication reduction as well as in absolute and qualified success rates. No significant difference was found in any parameters tested between Preserflo Microshunt with MMC 0.2 mg/ml and with or without OCM implantation at 6 months. Long-term follow-up is required to further evaluate this data.
Perineal stapled prolapse resection in combination with Thiersch operation for relapsed rectal prolapse: a case report
Authors: Kamada Teppei , Ohdaira Hironori , Takahashi Junji , Fuse Yoshinobu , Kai Wataru , Nakashima Keigo , Nakaseko Yuichi , Suzuki Norihiko , Yoshida Masashi , Usui Takeo , Suzuki Yutaka 
Published: September 2021

AbstractBackgroundTreatment options for complete rectal prolapse include over 100 procedures. In previous reports, operative rectal prolapse repair, regardless of the technique by perineal approach, was associated with high recurrence rates. However, there is no consensus on the optimal surgical procedure for relapsed rectal prolapse.Case presentationA 97-year-old woman was admitted to our hospital with a chief complaint of complete rectal prolapse measuring > 5 cm. The patient had a history of laparoscopic anterior suture rectopexy without sigmoid resection under general anesthesia for complete rectal prolapse one year prior. The patient’s postoperative course was uneventful. However, her dementia worsened (Hasegawa’s dementia scale: 5/30 points) after the first operation. Further, moderate-to-severe aortic valve stenosis was first diagnosed with heart failure 6 months after the operation. Nine months after the initial surgery, she experienced a recurrence of complete rectal prolapse measuring approximately 5 cm. Considering the coexistence of advanced age, severe dementia, and aortic valve stenosis, surgery under general anesthesia was not indicated. Perineal stapled prolapse resection in combination with the t operation was planned because of its minimal invasiveness and shortened hospital stay. The procedure was performed by a team of two surgeons in the jack knife position, under spinal anesthesia.The prolapse was cut along the long-axis direction with three linear staplers and resected along the short-axis direction with four linear staplers. The cross-section of the linear stapler was reinforced with 3-0 Vicryl sutures. After rectal resection, the Thiersch operation using 1-0 nylon thread 1 cm away from the anal verge was additionally performed. The operative time was 24 min, and intraoperative blood loss was 1 mL. The postoperative course was uneventful. Three months after the operation, no recurrence was observed, and defecation function was good with improvements of Wexner score.ConclusionsPerineal stapled prolapse resection in combination with the Thiersch operation could be a useful option for patients with relapsed rectal prolapse and with poor general condition, who are not indicated for other surgical procedures.
Pain management during labor: use of intermittent drug delivery devices for improvement of obstetric and neonatal outcome and reduction of healthcare burden: A large non-inferiority randomized clinical trial
Authors: Rinaldi Laura , Ghirardini Anna Maria , Troglio Raffaella , Bellini Valentina , Donno Lara , Biondini Susanna , Biagioni Emanuela , Baciarello Marco , Bignami Elena , Girardis Massimo 
Published: September 2021

Abstract
Background
Automated continuous epidural administration of local anesthetics provides a more stable analgesic block with decreasing of healthcare staff compared to manual boluses administration (TOP-UP) but is associated to high rate of operative vaginal delivery. We hypothesized that the use of programmed intermittent automated boluses (PIEB) is able to provide a good quality of analgesia and decreasing of anesthesiologic workload without increasing the rate of instrumental vaginal birth in comparison with TOP-UP technique. Laboring nulliparous woman aged between 18 and 46 years were randomized to epidural analgesia with 0.0625% levobupivacaine and sufentanil administered by PIEB or by TOP-UP techniques. Primary outcome was instrumental vaginal delivery rate and secondary outcomes were quality of analgesia, total and time-related drugs doses used, motor block, newborn outcome, and anesthesiologic workload.

Results
Six hundred twenty-nine were randomized, and 628 were included in the intention-to-treat analysis. The rate of instrumental vaginal delivery was similar in the PIEB and TOP-UP groups (13.2% vs 9.7%, OR 1.4 95% CI 0.8 to 2.5; p 0.21). There was no difference between groups regarding mode of delivery (cesarean section vs vaginal birth), newborn outcome, and motor block. Patients in the PIEB group received more total and time-related drugs doses and a better quality of analgesia. Anesthesiological workload was significantly reduced in the PIEB group.

Conclusions
Our study demonstrated that epidural anesthesia with programmed intermittent epidural boluses by an automated device provides an effective and safe management of labor analgesia with improvement of pain control and sparing of man workload compared to manual top-up protocols.
Emplotment beyond the Human Scale: On Deep Time and Narrative Nonlinearity
Authors: Caracciolo Marco 
Published: September 2021

AbstractIn the second volume of Time and Narrative (1985, 101–12), Paul Ricoeur distinguishes between two layers of temporality in Virginia Woolf's Mrs. Dalloway (1925): he calls them “monumental” time and “mortal” time. The former is connected with authority and British imperial politics; the latter is the subjective, highly malleable time of human experience. But there is another time, also active in Woolf's novel and in her oeuvre more generally, that Ricoeur seems to overlook. It is the “deep history” (Shryock and Smail 2011) of geological and planetary phenomena that vastly surpasses the time scale of individual humans or human societies, or even of the human species. This is not to say that narrative is at ease with this deep temporality; as a practice, it seems fundamentally skewed toward the ethical and hermeneutic concerns that Ricoeur foregrounds in his work. But deep time does surface in narrative; this article is concerned with the formal challenges raised by such surfacings.
Contrast-enhanced ultrasonography promotes differential diagnosis of ureteral neoplasms
Authors: Bai Yun , Lin Jun , Chen An , Bai Min , Li Chunxiao , Cai Yingyu , Yu Jie , Hu Wenjie , Du Lianfang , Li Fan 
Published: September 2021

Objective: To compare the diagnostic value of contrast-enhanced ultrasonography (CEUS) with baseline ultrasound (B-US) in ureteral neoplasms. Methods: Retrospective analysis, comprising clinical presentation, image appearances, and diagnostic results on B-ultrasound and CEUS, considering pathological result as a gold-standard, was conducted on the clinical information of 39 patients with ureteral neoplasms. CT urography was used to detect and confirm the presence of ureteral neoplasms. Both B-ultrasound and CEUS investigations of those 39 patients under study were performed by a senior radiologist. Results: Pathological outcomes established 27 ureteral malignancies and 12 ureteral benignancies. Ureteral malignancies were observed to occur in older patients than benignancies (p = 0.002). Only the morphological indicator of the ureteric wall on B-ultrasound was different in ureteral malignancies and benignancies (p = 0.030). Tumors with hyperenhancement, larger width, and hyperenhanced ureteric wall were easily diagnosed as malignant on CEUS, whereas iso-/hypoenhanced, narrower, and iso-/hypoenhanced ureteric wall indicated benign tumors. Moreover, the lesion widths, enhanced morphologies of the ureteric wall, and the ureteral wall’s linear boundaries on CEUS were different between high- and low-stage ureteral urothelial carcinomas (p = 0.012, 0.002, 0.001, respectively). Conclusion: The display of microvessels in ureteral neoplasms was significantly enhanced by CEUS, thus contributing to the differential diagnosis of ureteral neoplasms while assisting the staging of ureteral urothelial carcinoma. Advances in knowledge: The imaging features of different ureteral neoplasms on CEUS were analyzed in this study. The diagnostic performances of CEUS and B-ultrasound in ureteral urothelial carcinomas were also explored.
Case Report: Scientific Dissemination as a Mediator of the Research Consolidation Process: Proposals for Institutionalization
Authors: Galvão Tássia , Tavares Kamilla Assis , Fernandes Michele , Souza José Carlos Moreira de , Noll Matias 
Published: September 2021

Introduction Communicating science is one of the main steps in the research process. However, the method of communication must be aligned with the audience for the message. This is especially evident in institutions that promote teaching, research, and extension, especially when considering joint actions that promote a dialogue between themselves and the community. Methods In light of this need, this study was conducted with the aim of analyzing the main documents guiding the policies and institutional actions related to research at the two federal institutes based in the state of Goiás/Brazil: Institution A and Institution B and proposing ways to include scientific dissemination as a mediator of the research consolidation process. This is a bibliographic, documentary study with a descriptive, qualitative approach based on a case study. Results and Discussion The analyses indicate that research must be consolidated as institutional policy and that a policy to encourage research must be implemented. This has yet to be achieved at these institutions, although scientific dissemination is explicitly addressed by institutional documents guiding the development and dissemination of pedagogical practices, especially in teaching and extension. Scientific journalism and scientific dissemination are mediators and facilitators of this endeavor.
УПРАВЛЕНИЕ СОЦИАЛЬНОЙ СИСТЕМОЙ В УСЛОВИЯХ ВЗАИМОДЕЙСТВИЯ СОЦИУМА И ОБРАЗОВАТЕЛЬНОГО ПРОЦЕССА В ТЕХНИЧЕСКОМ ВУЗЕ
Authors: Bespalova Natalia A. , Sibirtsev Anton V. , Yakovleva Tatyana S. 
Published: September 2021

Цель. Статья посвящена актуальной в условиях развития высшего образования теме совершенствования управления социальной системой в условиях взаимодействия социума и образовательного процесса в техническом вузе. Актуальность темы статьи обусловлена тем, что правильный выбор моделей педагогического взаимодействия в техническом вузе и подходов в управлении социальной системой вуза позволит повысить качество образовательного процесса. Предметом исследования является социальная система технического вуза.
Методология. Основу исследования образуют следующие методы исследования: сущностный, структурно-функциональный, метод сравнения, и группа логических методов: анализ, синтез, обобщение.
Результаты. В результате исследования определены понятия социальной системы технического вуза, особенностей взаимодействия социума и образовательного процесса в техническом вузе. Рассмотрены особенности педагогического взаимодействия в рамках образовательного процесса на примере модели активного взаимодействия и либеральной модели. Дана характеристика основных подходов к управлению качеством подготовки выпускников технических вузов. Рассмотрены преимущества внедрения системы менеджмента качества в управление техническим вузом для укрепления взаимосвязей между наукой, высшим образованием и производством.
Область применения результатов. Результаты проведенного исследования могут использоваться на практике для повышения эффективности управления социальной системой технического вуза. Так, применение такой модели педагогического взаимодействия в рамках образовательного, как активное взаимодействия возможно на любом этапе образовательного процесса, а либеральная модель может применяться на этапе магистратуры или аспирантуры, а также второго высшего образования. Также для управления социальной системой вуза может быть применен подход, базирующийся на создании системы менеджмента качества предоставляемых услуг в соответствии с требованиями ГОСТа.
Выводы. Проведенное исследование позволило сделать выводы о преимуществах применения моделей активного взаимодействия и либеральной модели для совершенствования педагогического взаимодействия в техническом вузе. Рассмотрение особенностей педагогического взаимодействия в рамках образовательного процесса на примере модели активного взаимодействия и либеральной модели позволило определить, что применение модели активного взаимодействия возможно на любом этапе образовательного процесса, тогда как либеральная модель может применяться на этапе магистратуры или аспирантуры, а также второго высшего образования. Дана характеристика основных подходов к управлению качеством подготовки выпускников технических вузов. Сделан вывод о том, что для повышения эффективности взаимодействия социума и образовательного процесса в техническом вузе более подойдет подход, базирующийся на создании системы менеджмента качества предоставляемых услуг.
ИНТЕРПРЕТАЦИЯ РУССКИХ РЕАЛИЙ В ПЕРЕВОДАХ ПРОИЗВЕДЕНИЙ И.А. БУНИНА
Authors: Yavari Yulia V. , Dzhafarova Lyubov A. 
Published: September 2021

Статья посвящена анализу способов перевода на английский язык русских реалий, носителей национального и исторического колорита в произведениях И.А. Бунина «Деревня», «Суходол» и рассказе «Антоновские яблоки».
Цель исследования: описать и сравнить основные особенности перевода исследуемых лексических единиц и выявить наиболее продуктивные модели перевода реалий.
Методы исследования. Исследуемые реалии были определены методом сплошной выборки из повестей русского классика И.А. Бунина «Деревня», «Суходол» и рассказа «Антоновские яблоки». Основу исследования образуют структурный анализ и сравнительно-­описательный метод.
Результаты исследования. Сопоставительный анализ способов перевода реалий, обозначающих предметы быта, одежду, блюда, сословия, социальные группы и должности, характерные для жизни русской деревни 19 в., показал, что наиболее частотными способами, используемыми переводчиками, являются: транскрипция (как с пояснениями, так и без таковых), гиперонимический перевод, описательный перевод и замена реалии. Авторы статьи рассматривают художественный перевод как базу для пополнения литературного переводящего языка (ПЯ) новыми словами. В заключение сделан вывод, что, используя опыт перевода и опираясь на знание экстралингвистических факторов, можно достичь адекватного перевода.
Практическое применение результатов. Результаты исследования могут использоваться при чтении курсов лекций и проведении практических занятий по теории перевода в процессе обучения переводчиков в сфере профессиональной коммуникации.
Report on an Analytic Network Process (ANP) Model to Estimate the Benefits, Opportunities, Costs, and Risks (BOCR) that Gun Policies and Violence Prevention Interventions have on Legal Users of Firearms
Authors: Vargas Luis G , Guiora Amos N. , Minutolo Marcel C. 
Published: September 2021

Balancing public good with individual rights is a difficult task; gun policies attempt to do just this. To ensure public safety, local, state, and federal agencies piece together policies that each entity believes will meet the needs of public welfare. When legislating new gun policies, the impact the policies have on gun owners are perceived as a zero-sum game; some groups are perceived to gain while others think they are losing, but the reality is much more nuanced.

The reason the impact of these policies on all lawful gun owners has been considered a zero-sum game is largely because to date there has been no research measuring the impact. Further, there have been no attempts to quantify the impact that the policies have on lawful gun owners. The sole argument that has been made is about constitutionality.

In this paper, we develop an approach based on the Analytic Hierarchy Process (AHP). The approach allows us to develop criteria for evaluating the impact of these policies on lawful gun owners and generate priorities for the criteria from pairwise comparisons. Criteria are compared in pairs, thus the term pairwise comparisons. This allows us to score, as with a scorecard model, gun policies for various types of gun owners with respect to the criteria according to the Benefits, Opportunities, Costs, and Risks, thereby determining the impact of each policy.