bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vaginal-assisted Laparoscopic Sacrohysteropexy and Vaginal Hysterectomy with Vaginal Vault Suspension for Advanced Uterine Prolapse
Authors: Cengiz Huseyin , Yildiz Sukru , Alay Ismail , Kaya Cihan , Eren Ecem , Iliman Derya Ece 
Published: December 2021

Objective:
Vaginal-assisted laparoscopic sacrohysteropexy (VALH) is a new modified form of uterine-sparing prolapse surgery using a combined vaginal and laparoscopic approach. We aimed to compare 1 year efficacy and safety of VALH and vaginal hysterectomy with vaginal vault suspension (VH + VVS) in the surgical treatment of apical pelvic organ prolapse (POP).

Materials and Methods:
Women who requested surgical treatment for stage 2–4 symptomatic uterine prolapse were recommended to participate in one year-long randomized study between July 2017 and January 2019. POP Quantification (POP-Q) examination and validated questionnaires such as International Consultation on Incontinence Questionnaire Vaginal Symptoms (IVIQ-VS) survey, Urogenital Distress Inventory (UDI-6), Incontinence Impact Questionnaire Short Form (IIQ-7), and Patient Global Impression of Improvement (PGI-I) were recorded at baseline and 12 months after surgery. The main primary outcome measure was apical prolapse recurrence. Secondary results were duration of surgery, pain score, blood loss, postoperative hospital stay, and quality of life scores related to prolapse.

Results:
There were 15 women in VALH and 19 women in the VH + VVS group. ICIQ-VS score, ICIQ-QOL, UDI-6, and IIQ-7 scores were improved for both groups. According to the PGI-I scores, 80% of subjects in the VALH group, and 100% in the VH + VVS group, were “very much better” or “much better” with their prolapse symptoms at their 1-year follow-up. There was no reoperation or operation-related complication in both groups.

Conclusion:
VALH and VH + VVS have similar 1-year cure rates and patient satisfaction.
Postlaparoscopic Hysterectomy Discharge within 24 h in Hospital Putrajaya
Authors: Padzil Nurul Idayu Mohamad , D'silva Emily Christine , Safiee Anis Iryani , Ghazali Wan Ahmad Hazim Wan 
Published: December 2021

Objective:
The study objective was to determine the feasibility and selection criteria for discharge within 24 h posttotal laparoscopic hysterectomy with or without bilateral salpingo-oophorectomy (TLH with or without BSO) in Hospital Putrajaya.

Materials and Methods:
A total of thirty patients among all gynecology inpatients who were planned for TLH with or without BSO with controlled medical diseases, normal preoperative investigations, and uncomplicated surgery were recruited from January 2014 to December 2016. Data were collected from electronic medical records. Postoperatively, patients who fulfilled the selection criteria were discharged within 24 h and were followed up at 6 weeks and 3 months postsurgery. The results were presented as frequency with percentage and mean standard deviation.

Results:
All patients who had uncomplicated surgery and blood loss <1 l with no early postoperative complications were discharged within 24 h. They had a pain score of < 3 and were able to ambulate and tolerated orally well. None of these patients who were discharged 24 h postsurgery required readmissions. During follow-up, there were no reported complications such as persistent pain, wound infection, or herniation.

Conclusion:
Twenty-four hours' discharge post-TLH with or without BSO is feasible and safe if the selection process is adhered to.
Does Uterine Manipulator Type Affect Surgical Outcomes of Laparoscopic Hysterectomy?
Authors: Yavuzcan Ali , Altıntaş Raşit , Yıldız Gazi , Başbuğ Alper , Baştan Merve , Çağlar Mete 
Published: December 2021

Objectives:
Many surgeons use uterine manipulator (UM) during laparoscopic hysterectomy (LH). In this study, we aimed to compare the outcomes of LH operations performed by using partially reusable UM with the articulated system (artUM) and disposable (dUM) UM without articulation.

Materials and Methods:
A total of 99 patients underwent the LH operation. This study was carried out with 35 of those 99 Caucasian patients who met the inclusion criteria. Group 1 consisted for 7 LH operations using the articulated RUMI® II/KOH-Efficient™ (Cooper Surgical, Trumbull, CT, USA) system (artUM), while Group II consisted of 28 patients using old-type V Care®(ConMed Endosurgery, Utica, New York, USA) dUM as UM.

Results:
Mean operation time was found to be 157.1 ± 42.0 min. The operation time was found statistically longer in Group 1, consisted of artUM used patients (P = 0.006 and P < 0.05). No statistically significant difference was found between two groups in terms of surgical results such as, delta hemoglobin value (P = 0.483 and P < 0.05), length of hospital stay (P = 0.138 and P < 0.05), and postoperative maximum body temperature (P = 0.724 and P < 0.05).

Conclusion:
The UM type did not alter the surgical outcomes except the operating time in our study. According to our results, the surgical technique is a more significant variable than instruments used in LH for normal size uterus. Further prospective, large-scale studies comparing various UM systems are mandatory.
Abnormal Urine Outflow from the Ureteral Orifice on Cystoscopy Following Vaginal Stump Suture in Total Laparoscopic Hysterectomy
Authors: Kobayashi Hiroharu , Iga Kentaro , Kato Keiichiro , Kato Airi , Otsuka Koji , Soga Eri , Konno Hiroko , Nakayama Satoru , Shiojima Satoshi 
Published: December 2021

Objectives:
Ureteral injuries may occur subsequent to abdominal or laparoscopic hysterectomy. In total laparoscopic hysterectomy (TLH), we usually check for ureteral damage by confirming urinary outflow from the bilateral ureteral orifices by cystoscopy after vaginal stump suture. In this work, we investigated the causes of urine outflow disruption after TLH.

Materials and Methods:
We conducted a retrospective review of all TLHs performed for benign diseases at our hospital from February 2012 to March 2016. There were 11 cases with no or poor urine outflow from the ureteral orifice after vaginal stump suture. For these cases, we assessed the treatment to recover urine outflow and examined the cases with intraoperative manipulation. EZR version 1.25 was used for statistical analysis. Correlation coefficients were calculated with Spearman's rank correlation coefficient test.

Results:
The abnormality was on the right and left sides in seven and four cases, respectively. In all cases, apart from one, urine outflow was recovered by removing the sutures at the affected side, where the initial suture had included a small amount of the connective tissue near the urinary bladder. It was inferred that ureteral deviation due to vaginal stump sutures that picked up the connective tissue near the ureter caused ureteral peristaltic disorder and abnormal ureteral orifice outflow.

Conclusion:
TLH without ureter isolation requires sufficient separation of the bladder from the anterior vaginal wall and careful vaginal stump suture without involving the bladder-side tissue to avoid ureteral injury.
Comparative clinical assessment of 5% minoxidil topical application with supplemental intradermal meso-solution administration for the management of androgenetic alopecia in men
Authors: Gupta Neha , Kohli Sarvraj 
Published: December 2021

Objectives:
Androgenetic alopecia (AGA) is characterized by progressive patterned hair loss from the scalp affecting both men and women. The aim of this study was to evaluate the influence of intradermal administration of meso-solution (MS) along with topical application of 5% minoxidil lotion on hair re-growth.

Materials and Methods:
Sixty healthy adult men (32.6 ± 4.3 years of age) with a history of hair loss completed the 12-month study. They were equally randomized into two groups. Subjects enrolled in Group A (n
1 = 30) received once-daily topical application of 5% minoxidil lotion, whereas those in Group B (n
2 = 30) received additional intradermal injection of MS (Stem C’rum HL, Caregen Co. Ltd, Anyang-si, Gyeonggi-do, South Korea) using a mesogun every 15 days for 3 months and then once every month for 9 months. Hair re-growth was evaluated using a 7-point rating scale.

Results:
Data collected were subjected to chi-square test. Results indicate that there is a statistically significant (P < 0.05) increase in hair re-growth in individuals in Group B at 6 months. This progressed to a highly significant (P < 0.001) increase at 9 and 12 months.

Conclusion:
Intradermal administration of MS using a mesogun along with minoxidil yielded a statistically significant increase in hair re-growth as compared to only minoxidil application.
Effective Treatment Option for Lichen Planus
Authors: Parlapalli Neelima , Priscilla Tina 
Published: December 2021

Background:
Data on safety and efficacy of low molecular weight heparin (LMWH) in lichen planus (LP) and comparison with oral corticosteroids (OCs) in Indian patients is limited.

Aims:
The aim of this article is to compare the clinical efficacy of LMWH and systemic corticosteroids in LP.

Materials and Methods:
This study was a single-center prospective comparative study. The patients received either LMWH subcutaneously (3 mg weekly for 6 weeks) or OC (20 mg/day for 6 weeks, tapered gradually).

Results:
Fifty patients were enrolled in the study, and 35 (70.0%) were females. Mean age of the study population was 35.46 years with age ranging between 21 and 40 years. Itching (92.0%) was a common symptom; generalized cutaneous lesions (90.0%) and involvement of mucous membrane were seen in 40%. Classical LP was common (56.0%). Early results were seen with OC (week 4) compared to LMWH (week 5); higher cure rate was seen with OC (89.47% vs. 76.0%) at week 6. There was no significant statistical difference (P > 0.05) in the therapeutic response between the study groups. No new lesions were noted in 23 and 13 patients treated with OC and LMWH, respectively. Relapse rate (33.33%) was higher in patients treated with LMWH (P < 0.05). Treatment with low-dose LMWH was associated with no side effects, whereas gastric irritation (42.1%) was the most common side effect followed by facial puffiness (31.57%) and acneiform eruptions (26.31%) with OC. The cost of treatment was more for LMWH compared with OC.

Conclusion:
Both treatment modalities were comparable in efficacy and tolerated well. LMWH had no adverse effect but had a high relapse rate. Therapy with OC is cost-effective.
Morphometric analysis of itraconazole pellets of commonly available brands using dermoscopy
Authors: Pise Gajanan A. , Komala H. T. , Dastikop Shilpa V. , Manohar Naveen , Akshay L. M. , Sanagoudar Vinitha 
Published: December 2021

Introduction:
Itraconazole (ITZ) is commonly used to treat cutaneous and systemic mycoses. The bioavailability of ITZ capsules varies between individuals; therefore, the quality of ITZ pellets is a major determinant of their absorption and therapeutic efficacy. Morphometric analysis is a surrogate method of evaluating the absorption and efficacy of ITZ capsules, and the number and size of pellets in each capsule are the most important morphometric parameters.

Aim:
To analyze the morphometric characteristics of commonly available brands of ITZ.

Materials and Methods:
Commonly available formulations of ITZ in the market were analyzed using a hand-held dermoscope. Morphometric characteristics of 30 and 10 brands of 100-mg and 200-mg formulations were analyzed, respectively. A dermoscope was used to determine the size and the number of pellets per capsule. Furthermore, variations in the size of pellets across brands were compared to that in the global innovator brand. Statistical analysis used was SPSS v. 21 (IBM Inc., Armonk, NY).

Results:
The capsules included 126–1010 pellets of 788–2343 µm, and dummy pellets and loose powder were found in some brands. Five brands that cost <20 Indian rupees (INR) per capsule included good pellet count, small pellet size, and low size variation. Two other brands included these qualities but were priced at INR 20–30 per capsule. The size variation was the minimum, and no dummy particles or loose powder were observed with the innovator brand; however, it was the costliest.

Conclusion:
The morphometric characteristics of ITZ formulations varied significantly between brands, which may significantly affect their efficacy.
The association of advanced maternal age with maternal and neonatal outcomes of pregnancy in Filipino patients in a tertiary medical center
Authors: Gamboa-Chua Leolina Remeceta M , Soriano-Estrella Agnes L. 
Published: December 2021

BACKGROUND:
For the past decade, advanced maternal age (AMA) became more common in developed and developing countries due to the postponement of pregnancy because of career goals, widespread use of family planning, and advances in assisted reproductive techniques. This increase bears an impact on maternal and perinatal outcomes. The link between AMA and adverse maternal, perinatal, and neonatal outcome showed contradicting results. This study was conducted to investigate the association between AMA and adverse outcomes among nulliparous, Filipino with singleton pregnancies who gave birth in a private tertiary hospital.

METHODOLOGY:
Medical records of patients admitted for delivery between January 2015 and December 2019 were reviewed retrospectively. The control (20–34 years), AMA 35–39 years, very AMA 40–44 years, and extremely advanced maternal age (EAMA) 45 years and above groups included 206, 111, 18, and 2, respectively.

RESULTS:
Five-year total deliveries at a private tertiary hospital were 8495 with a prevalence of 38.9% (95% confidence interval CI: 33.6%–44.3%) for elderly Filipino primigravids. AMA is a risk factor for diabetes mellitus and small for gestational age newborn in all 3 advanced age groups. Pregnancy induced hypertension, having cesarean section, admission of newborn to neonatal intensive care unit, and administration of antibiotics were more common to AMA but same risk for EAMA. AMA predisposes to having oligohydramnios, placenta previa and preterm delivery but pregnancy at EAMA predisposes more complications in maternal and neonatal outcomes such as having polyhydramnios, abruptio placenta, postpartum hemorrhage, maternal and neonatal death, low Appearance Pulse Grimace Activity and Respiration score, and stillbirth. There is no noted association between AMA and large for gestational age newborn, having meconium staining and delivering by classical cesarean section.

CONCLUSION:
AMA in Filipino gravida patients is markedly linked with adverse obstetrical, perinatal, and neonatal outcomes. This study confirms the current trend among women over 45 years that leads to more significant obstetric complications and neonatal morbidities.
Sperm Motility is the Best Semen Parameter to Predict Sperm DNA Fragmentation
Authors: Huang Wei-Lun , Chang Yi-Kai , Tung Sheng-Yung , Peng Bo-Hua , Chang Hong-Chiang 
Published: December 2021

Purpose:
Sperm DNA fragmentation (SDF) is associated with male infertility and abnormal semen parameters. However, the effect of SDF on each parameter may differ. In this study, we evaluated the correlation between different semen parameters and SDF to identify the most suitable predictor for abnormal SDF.

Materials and Methods:
We conducted a retrospective review from a prospective database. Enrollees who underwent conventional semen analysis and an SDF test for medical purposes or elective examinations were enrolled. SDF ≥20% was regarded as abnormal. Spearman correlation coefficient was used to determine the correlations. Area under the receiver operating characteristic curve area under the curve (AUC) was calculated to determine the predictive value. Youden index was used to determine the optimal cutoff value of conventional semen parameters to predict abnormal SDF.

Results:
In total, 90 men were enrolled, of whom 44 (48.89%) visited for infertility and 51 (56.67%) had abnormal semen analysis. Immotile sperm (IM) and nonprogressive sperm (NPS, NPS = nonprogressive motility + IM) were significantly correlated with SDF (r = 0.50, P< 0.001 for NPS; r = 0.49, P< 0.001 for IM) and were the most predictive for abnormal SDF (AUC = 0.77 for NPS; AUC = 0.78 for IM). By using Youden index, the cutoff values for the prediction of abnormal SDF were 66.37% for NPS and 48.73% for IM.

Conclusion:
Sperm motility is the most predictive and relevant parameter for the prediction of abnormal SDF. Suboptimal sperm motility should be considered an indication for SDF testing.
Measuring Individual Ureteral Length Using Computed Tomography Urography to Determine the Appropriate Lengths of Ureteral Stents
Authors: Tsai Cheng-Han , Huang I-Shen , Chen Wei-Jen , Cheng Wei-Ming , Chiang Cheng-Yen , Kao Wei-Tang , Huang Eric Yi-Hsiu , Huang William J. 
Published: December 2021

Purpose:
The purpose of the study was to describe and validate a method for calculating ureteral length using computed tomography (CT) images acquired before ureteral stent placement and to evaluate the appropriateness of fit based on this calculation.

Materials and Methods:
We analyzed 57 patients who underwent computed tomography urography (CTU). The axial ureteral length (AUL) and coronal ureteral length (CUL) were derived from measurements made on the CTU images, and the length of each patient-specific ureteral stent was chosen based on the calculated ureteral length.

Results:
Overall, 105 ureters were measured: 54 (51.4%) right side and 51 (48.6%) left side ureters. The mean CUL and AUL of right ureters were 22.5 ± 2.3 cm and 22.5 ± 2.3 cm, respectively, whereas the mean CUL and AUL of left ureters were 23.6 ± 2.2 cm and 23.4 ± 2.1 cm, respectively. Pearson correlation analysis showed that body height was significantly correlated with ureteric length (right CUL and patient height: r =0.441, P= 0.001; right AUL and patient height: R = 0.445, P= 0.001; left CUL: R = 0.341, P= 0.029; left AUL: R = 0.339, P= 0.015). Thirteen of 57 patients underwent ureteral stent insertion; none experienced stent migration (upward or downward) before the removal of the ureteral stent. Comparison of proposed stent size with actual stent size in the 13 patients shows the percentage of size appropriateness (as defined by concordance between proposed and actual stent length) to be 76.9% (10/13).

Conclusion:
The patient's height was found to correlate significantly with CT-derived measurements of ureteral length. Accordingly, the choice of ureteral stent length can be reliably decided from CT measurements.
AVALIAÇÃO DE OCORRÊNCIA DE MANIFESTAÇÕES PATOLÓGICAS EM SISTEMAS PREDIAIS HIDROSSANITÁRIOS NOS PRIMEIROS ANOS DE USO E OPERAÇÃO
Authors: Salomão Rael de Morais Lucas , Martins de Paula Heber , Prado Abreu Reis Ricardo 
Published: December 2021

RESUMO: Considerando que as ações de avaliação de desempenho de edificações e de manutenção predial vêm ganhando ênfase nos últimos anos, a identificação de patologias nos sistemas prediais e a sua detecção precoce estão sendo tratadas mais a sério. Destaca-se o grande número de registros de patologias nos sistemas prediais hidrossanitários (SPHS), devido suas características de heterogeneidade de seus elementos e o elevado grau de interação com os usuários. Este artigo tem o objetivo de avaliar a ocorrência de manifestações patológicas em edifícios públicos nos seus primeiros anos de uso e operação através da avaliação de relatórios de ordens de serviço de manutenção predial da Universidade Federal de Goiás durante o período de 2012 a 2019. A partir dessas informações, foi avaliada a participação das edificações com pouca idade na manutenção predial da instituição e identificar quais foram os tipos de manifestações patológicas relatadas nesses edifícios. Observou-se participação significativa de edifícios com menos de 5 anos nas requisições de manutenção dos SPHS. A ocorrência de manifestações patológicas foi relacionada ao uso de materiais de baixa qualidade e deficiências nas etapas de projeto, execução e fiscalização da obra.
Comparison of the biomechanical parameters during drop jump on compliant and noncompliant surfaces: A new methodological approach
Authors: Özdalyan Fırat , Gümüş Hikmet , Gençoğlu Celal , Tunar Mert , Çetinkaya Caner , Muammer Kayatekin Berkant 
Published: December 2021

Objective:Bilateral plyometric training of the lower extremities has been shown to provide improvement in vertical force production. However, designing a proper plyometric training program and choosing the appropriate surface is critical, otherwise the risk of injury and lower extremity joint pathologies increases. The aim of this study was to compare biomechanical parameters between mini-trampoline and noncompliant surface during drop jumping.Materials and Methods:Thirty-four male adults participated in the study. Active markers were placed on the left knee, ankle and hip joints of the participants. Also, a force sensing resistor was placed under the participants’ left shoes. During drop jumping, the knee joint angles were recorded by the camera while adataset of reaction forces and loading rates were collected using a force sensing resistor. Data were compared with paired samples T-test. The level of significance was set atp≤ 0.05.Results:The mean values of maximum reaction forces and loading rates were greater on the noncompliant surface (p< 0.001). Mean knee joint angles for frame at which the knee angle is minimum and the frames one before and one after the frame at which the minimum value is obtained were similar between surfaces, however, were found to be smaller on noncompliant surface for the remaining eight frames (p< 0.05).Conclusion:This study indicates that the range of bending values in the knee joint is greater on noncompliant surface compared to mini-trampoline during drop jump. Since the mini-trampoline resulted in lower reaction forces and loading rates, it can be used as an exercise equipment to minimize the injury risk of plyometric training.
EFEK TERAPI MUSIK & DEEP BREATHING EXERCISE TERHADAP PENURUNAN NYERI, FREKUENSI NADI, FREKUENSI PERNAPASAN PADA PASIEN KANKER PARU
Authors: Veranita Aprillia , Widani Ni Luh , Susilo Wilhelmus Hary 
Published: December 2021

Pendahuluan: Kanker paru adalah pertumbuhan sel yang tidak terkendali pada paru-paru yang sering menimbulkan nyeri dan sesak napas. Manajemen nyeri yang tepat diperlukan untuk menangani respon nyeri. Penelitian ini bertujuan untuk mengetahui pengaruh terapi musik & Deep Breathing Exercise (DBE) terhadap penurunan nyeri, frekuensi nadi dan pernapasan pada pasien kanker paru.
Metode: Penelitian ini merupakan studi quasi experimental pre-post test with control group dengan teknik purposive sampling ,terdiri dari 86 responden kelompok intervensi dan 22 kelompok kontrol di RSUP Persahabatan. Nyeri diukur dengan Numeric Rating Scale (NRS). Analisis yang digunakan adalah Uji regresi linear berganda, Paired sampel t-test, Independent t-test.
Hasil: Hasil penelitian menunjukan perbedaan bermakna nilai skala nyeri, frekuensi pernapasan dan nadi sebelum dan sesudah intervensi terapi musik dan Deep Breathing Exercise (DBE) (p=0,000).
Kesimpulan: Penurunan skala nyeri, frekuensi pernapasan dan nadi kelompok intervensi lebih besar dari pada kelompok kontrol. Penelitian ini merekomendasikan terapi musik & DBE sebagai intervensi mandiri keperawatan untuk mengurangi nyeri kanker paru.