bluuebunny/crossref_metadata_2025_split huggingface dataset:
How have journalists been affected psychologically by their coverage of the COVID-19 pandemic? A descriptive study of two international news organisations
Authors: Osmann Jonas , Selva Meera , Feinstein Anthony 
Published: July 2021

ObjectivesThe COVID-19 pandemic has presented unprecedented healthcare challenges. Journalists covering the pandemic at close quarters are working in ways akin to first responders, but nothing to date is known of the psychological distress this is potentially causing them. This study aims to determine whether journalists reporting on the COVID-19 crisis have been affected emotionally, and if so to assess the severity of their distress. It also investigates potential demographic and work-related predictors and whether news organisations had provided counselling to their journalists.ParticipantsA total of 111 journalists working for two international news organisations were approached of which 73 (66%) participated in the study.Primary and secondary outcome measuresSymptoms of anxiety (Generalised Anxiety Disorder Scale-7 (GAD-7)), depression (Patient Health Questionnaire (PHQ-9)), posttraumatic stress disorder (PTSD; PTSD Checklist for DSM-5 (PCL-5)), overall psychological distress (12-item General Health Questionnaire (GHQ-12)), and treatment.ResultsThe percentages of journalists exceeding threshold scores for clinically significant anxiety, depression, PTSD and psychological distress were: GAD-7, 26%; PHQ-9, 20.5%; PCL-5, 9.6%; GHQ-12, 82.2%. Journalists assigned to cover the pandemic (n=54 (74%)) were significantly more anxious (p<0.05). Journalists who received counselling (n=38 (52%)) following the onset of the pandemic reported significantly fewer symptoms of anxiety (p<0.01), depression (p<0.01) and overall psychological distress (p<0.01).ConclusionsJournalists covering the COVID-19 pandemic are experiencing levels of anxiety and depression similar to those seen in first responders. Psychological therapy provided in a timely manner can significantly alleviate emotional distress.
Disease burden of diabetes, diabetic retinopathy and their future projections in the UK: cross-sectional analyses of a primary care database
Authors: Haider Sajjad , Thayakaran Rasiah , Subramanian Anuradha , Toulis Konstantinos A , Moore David , Price Malcolm James , Nirantharakumar Krishnarajah 
Published: July 2021

ObjectivesTo estimate the current disease burden, trends and future projections for diabetes mellitus (DM) and diabetic retinopathy (DR) in the IQVIA Medical Research Data (IMRD).Participants/design/settingWe performed a cross-sectional study of patients aged 12 and above to determine the prevalence of DM and DR from the IMRD database (primary care database) in January 2017, involving a total population of 1 80 824 patients with DM. We also carried out a series of cross-sectional studies to investigate prevalence trends, and then applied a double exponential smoothing model to forecast the future burden of DM and DR in the UK.ResultsThe crude DM prevalence in 2017 was 5.2%. The DR, sight-threatening retinopathy (STR) and diabetic maculopathy prevalence figures in 2017 were 33.78%, 12.28% and 7.86%, respectively, in our IMRD cross-sectional study. There were upward trends in the prevalence of DM, DR and STR, most marked and accelerating in STR in type 1 DM but slowing in type 2 DM, and in the overall prevalence of DR.ConclusionOur results suggest differential rising trends in the prevalence of DM and DR. Preventive strategies, as well as treatment services planning, can be based on these projected prevalence estimates. Improvements that are necessary for the optimisation of care pathways, and preparations to meet demand and capacity challenges, can also be based on this information. The limitations of the study can be overcome by a future collaborative study linking DR screening and hospital eye services data.
Effectiveness of contact tracing apps for SARS-CoV-2: a rapid systematic review
Authors: Jenniskens Kevin , Bootsma Martin C J , Damen Johanna A A G , Oerbekke Michiel S , Vernooij Robin W M , Spijker René , Moons Karel G M , Kretzschmar Mirjam E E , Hooft Lotty 
Published: July 2021

ObjectiveTo systematically review evidence on effectiveness of contact tracing apps (CTAs) for SARS-CoV-2 on epidemiological and clinical outcomes.DesignRapid systematic review.Data sourcesEMBASE (OVID), MEDLINE (PubMed), BioRxiv and MedRxiv were searched up to 28 October 2020.Study selectionStudies, both empirical and model-based, assessing effect of CTAs for SARS-CoV-2 on reproduction number (R), total number of infections, hospitalisation rate, mortality rate, and other epidemiologically and clinically relevant outcomes, were eligible for inclusion.Data extractionEmpirical and model-based studies were critically appraised using separate checklists. Data on type of study (ie, empirical or model-based), sample size, (simulated) time horizon, study population, CTA type (and associated interventions), comparator and outcomes assessed, were extracted. The most important findings were extracted and narratively summarised. Specifically for model-based studies, characteristics and values of important model parameters were collected.Results2140 studies were identified, of which 17 studies (2 empirical, 15 model-based studies) were eligible and included in this review. Both empirical studies were observational (non-randomised) studies and at high risk of bias, most importantly due to risk of confounding. Risk of bias of model-based studies was considered low for 12 out of 15 studies. Most studies demonstrated beneficial effects of CTAs on R, total number of infections and mortality rate. No studies assessed effect on hospitalisation. Effect size was dependent on model parameters values used, but in general, a beneficial effect was observed at CTA adoption rates of 20% or higher.ConclusionsCTAs have the potential to be effective in reducing SARS-CoV-2 related epidemiological and clinical outcomes, though effect size depends on other model parameters (eg, proportion of asymptomatic individuals, or testing delays), and interventions after CTA notification. Methodologically sound comparative empirical studies on effectiveness of CTAs are required to confirm findings from model-based studies.
Predictors of ophthalmology career success (POCS) study
Authors: Das Aditi , Smith Daniel , Mathew Rashmi G 
Published: July 2021

ObjectiveOphthalmology is the busiest outpatient specialty with demand predicted to rise over 40% in the next 20 years. A significant increase in the number of trainee ophthalmologists is required to fill currently vacant consultant posts and meet the UK’s workforce demands by 2038. Our aim was to understand what determines success in ophthalmology training, in order to inform future ophthalmologists, refine recruitment and facilitate workforce planning.Methods and AnalysisThis was a retrospective longitudinal cohort study using routinely collected data available from UK Medical Education Database (UKMED) (https://www.ukmed.ac.uk/). Data were analysed on 1350 candidates who had applied for ophthalmology specialty training (OST) between 2012 and 2018, as well as 495 candidates who had attempted Fellow of the Royal College of Ophthalmologists (FRCOphth) Part 1 between 2013 and 2018. Participants who had not obtained their primary medical qualification from the UK medical schools were excluded. Primary outcome measures included gaining a place on the OST programme and passing the FRCOphth Part 1 examination on first attempt.ResultsHigher education performance measure decile scores at medical school are strongly predictive in securing an OST post and passing the part 1 examination first time (p<0.001). Candidates who attempt FRCOphth Part 1 prior to their ST1 application are more likely to get a place on OST on first attempt. Socioeconomic factors, gender and ethnicity do not influence success in OST entry. Male trainees are more likely to pass FRCOphth Part 1 on their first attempt.ConclusionThis study is the first quantitative assessment of the factors that determine success in OST recruitment and ophthalmology postgraduate examinations in the UK. Similar studies should be undertaken in all other medical and surgical specialties to understand what factors predict success.
Helicobacter pylori infection has a detrimental impact on the efficacy of cancer immunotherapies
Authors: Oster Paul , Vaillant Laurie , Riva Erika , McMillan Brynn , Begka Christina , Truntzer Caroline , Richard Corentin , Leblond Marine M , Messaoudene Meriem , Machremi Elisavet , Limagne Emeric , Ghiringhelli Francois , Routy Bertrand , Verdeil Gregory , Velin Dominique 
Published: July 2021

ObjectiveIn this study, we determined whether Helicobacter pylori (H. pylori) infection dampens the efficacy of cancer immunotherapies.DesignUsing mouse models, we evaluated whether immune checkpoint inhibitors or vaccine-based immunotherapies are effective in reducing tumour volumes of H. pylori-infected mice. In humans, we evaluated the correlation between H. pylori seropositivity and the efficacy of the programmed cell death protein 1 (PD-1) blockade therapy in patients with non-small-cell lung cancer (NSCLC).ResultsIn mice engrafted with MC38 colon adenocarcinoma or B16-OVA melanoma cells, the tumour volumes of non-infected mice undergoing anticytotoxic T-lymphocyte-associated protein 4 and/or programmed death ligand 1 or anti-cancer vaccine treatments were significantly smaller than those of infected mice. We observed a decreased number and activation status of tumour-specific CD8+ T cells in the tumours of infected mice treated with cancer immunotherapies independent of the gut microbiome composition. Additionally, by performing an in vitro co-culture assay, we observed that dendritic cells of infected mice promote lower tumour-specific CD8+ T cell proliferation. We performed retrospective human clinical studies in two independent cohorts. In the Dijon cohort, H. pylori seropositivity was found to be associated with a decreased NSCLC patient survival on anti-PD-1 therapy. The survival median for H. pylori seropositive patients was 6.7 months compared with 15.4 months for seronegative patients (p=0.001). Additionally, in the Montreal cohort, H. pylori seropositivity was found to be associated with an apparent decrease of NSCLC patient progression-free survival on anti-PD-1 therapy.ConclusionOur study unveils for the first time that the stomach microbiota affects the response to cancer immunotherapies and that H. pylori serology would be a powerful tool to personalize cancer immunotherapy treatment.
Adverse effects related to tattoos in the community setting: a systematic review
Authors: Sindoni Alessandro , Valeriani Federica , Gallè Francesca , Liguori Giorgio , Romano Spica Vincenzo , Vitali Matteo , Protano Carmela 
Published: July 2021

BackgroundTattoos were historically associated with deviant behaviours or religious and other social purposes, but in the last decades, they have gained increasing popularity and have become a mainstream. The aim of this systematic review is to assess the literature evidence about decorative tattoos complications, considering both infective and non-infective risks.MethodsThis systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement. We searched the following electronic bibliographic databases: PubMed, Scopus and Web of Science (science and social science citation index).ResultsThe literature search resulted in 6473 studies. A total of 207 full articles were considered potentially relevant and were reviewed independently by researchers. After full-text evaluation, 152 of 207 articles were excluded, as they did not meet selection criteria. The remaining 55 studies were included in the systematic review and their quality assessment was performed. Ten studies reported microbiological complications, 37 reported non-microbiological effects and eight reported either microbiological and non-microbiological complications.ConclusionsSeveral well-known and uncommon risks are associated with tattooing and tattoo after-care. Public health authorities could take into account health education programmes for tattooists and customers in order to prevent health complications in people with tattoos.PROSPERO registration numberCRD42020177972.
Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study
Authors: Sinha Pratik , Delucchi Kevin L , Chen Yue , Zhuo Hanjing , Abbott Jason , Wang Chunxue , Wickersham Nancy , McNeil J Brennan , Jauregui Alejandra , Ke Serena , Vessel Kathryn , Gomez Antonio , Hendrickson Carolyn M , Kangelaris Kirsten N , Sarma Aartik , Leligdowicz Aleksandra , Liu Kathleen D , Matthay Michael A , Ware Lorraine B , Calfee Carolyn S 
Published: July 2021

RationaleUsing latent class analysis (LCA), two subphenotypes of acute respiratory distress syndrome (ARDS) have consistently been identified in five randomised controlled trials (RCTs), with distinct biological characteristics, divergent outcomes and differential treatment responses to randomised interventions. Their existence in unselected populations of ARDS remains unknown. We sought to identify subphenotypes in observational cohorts of ARDS using LCA.MethodsLCA was independently applied to patients with ARDS from two prospective observational cohorts of patients admitted to the intensive care unit, derived from the Validating Acute Lung Injury markers for Diagnosis (VALID) (n=624) and Early Assessment of Renal and Lung Injury (EARLI) (n=335) studies. Clinical and biological data were used as class-defining variables. To test for concordance with prior ARDS subphenotypes, the performance metrics of parsimonious classifier models (interleukin 8, bicarbonate, protein C and vasopressor-use), previously developed in RCTs, were evaluated in EARLI and VALID with LCA-derived subphenotypes as the gold-standard.ResultsA 2-class model best fit the population in VALID (p=0.0010) and in EARLI (p<0.0001). Class 2 comprised 27% and 37% of the populations in VALID and EARLI, respectively. Consistent with the previously described ‘hyperinflammatory’ subphenotype, Class 2 was characterised by higher proinflammatory biomarkers, acidosis and increased shock and worse clinical outcomes. The similarities between these and prior RCT-derived subphenotypes were further substantiated by the performance of the parsimonious classifier models in both cohorts (area under the curves 0.92–0.94). The hyperinflammatory subphenotype was associated with increased prevalence of chronic liver disease and neutropenia and reduced incidence of chronic obstructive pulmonary disease. Measurement of novel biomarkers showed significantly higher levels of matrix metalloproteinase-8 and markers of endothelial injury in the hyperinflammatory subphenotype, whereas, matrix metalloproteinase-9 was significantly lower.ConclusionPreviously described subphenotypes are generalisable to unselected populations of non-trauma ARDS.
Development and validation of a method to predict the soil thermal conductivity using thermal piezocone penetration testing (T-CPTU)
Authors: Liu Xiaoyan , Congress Surya Sarat Chandra , Cai Guojun , Liu Lulu , Liu Songyu , Puppala Anand J. , Zhang Wenwei 
Published: July 2021

A new in situ thermal piezocone penetration test (T-CPTU) system is developed to determine the thermal properties of soil. It is expected to overcome most of the shortcomings observed in existing in situ test techniques. Based on Fourier's heat conduction equation and pore pressure dissipation theoretical equation, a method for calculating the thermal conductivity, namely the predicted temperature method, was proposed. The accuracy of the T-CPTU probe testing process and thermal conductivity calculation results were verified by numerical simulation, laboratory large-scale model tank tests, and thermal needle tests. Finally, the field data of T-CPTUs at three sites in Nanjing, China, were collected and compared with the laboratory thermal needle tests. The results indicated that the thermal conductivities obtained using T-CPTU were accurate and closer to those of laboratory thermal needle tests for most soils. The thermal conductivities of the undisturbed soil samples measured in the laboratory were lower than those obtained by T-CPTU.
Phenothiazines as dual inhibitors of SARS-CoV-2 main protease and COVID-19 inflammation
Authors: Forrestall Katrina L. , Burley Darcy E. , Cash Meghan K. , Pottie Ian R. , Darvesh Sultan 
Published: July 2021

COVID-19, caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2), currently has no treatment for acute infection. The main protease (Mpro) of SARS-CoV-2 is an essential enzyme for viral replication and an attractive target for disease intervention. The phenothiazine moiety has demonstrated drug versatility for biological systems, including inhibition of butyrylcholinesterase, a property important in the cholinesterase anti-inflammatory cascade. Nineteen phenothiazine drugs were investigated using in silico modelling techniques to predict binding energies and inhibition constants (Ki values) with SARS-CoV-2 Mpro. Because most side-effects of phenothiazines are due to interactions with various neurotransmitter receptors and transporters, phenothiazines with few such interactions were also investigated. All compounds were found to bind to the active site of SARS-CoV-2 Mpro and showed Ki values ranging from 1.30 to 52.4 µM in a rigid active site. Nine phenothiazines showed inhibition constants <10 µM. The compounds with limited interactions with neurotransmitter receptors and transporters showed micromolar (µM) Ki values. Docking results were compared with remdesivir and showed similar interactions with key residues Glu-166 and Gln-189 in the active site. This work has identified several phenothiazines with limited neurotransmitter receptor and transporter interactions and that may provide the dual action of inhibiting SARS-CoV-2 Mpro to prevent viral replication and promote the release of anti-inflammatory cytokines to curb viral-induced inflammation. These compounds are promising candidates for further investigation against SARS-CoV-2.
Deuterium scattering experiments in CTEQ global QCD analyses: a comparative investigation
Authors: Accardi A. , Hobbs T. J. , Jing X. , Nadolsky P. M. 
Published: July 2021

AbstractExperimental measurements in deep-inelastic scattering and lepton-pair production on deuterium targets play an important role in the flavor separation of u and d (anti)quarks in global QCD analyses of the parton distribution functions (PDFs) of the nucleon. We investigate the impact of theoretical corrections accounting for the light-nuclear structure of the deuteron upon the fitted u, d-quark, gluon, and other PDFs in the CJ15 and CT18 families of next-to-leading order CTEQ global analyses. The investigation is done using the $$L_2$$

L
2

sensitivity statistical method, which provides a common metric to quantify the strength of experimental constraints on various PDFs and ratios of PDFs in the two distinct fitting frameworks. Using the $$L_2$$

L
2

sensitivity and other approaches, we examine the compatibility of deuteron data sets with other fitted experiments under varied implementations of the deuteron corrections. We find that freely-fitted deuteron corrections modify the PDF uncertainty at large momentum fractions and will be relevant for future PDFs affecting electroweak precision measurements.
Thermal monitoring to infer possible interactions between shallow hydrothermal system and slope-scale gravitational deformation of Mt Epomeo (Ischia Island, Italy)
Authors: Della Seta M. , Esposito C. , Fiorucci M. , Marmoni G. M. , Martino S. , Sottili G. , Belviso P. , Carandente A. , de Vita S. , Marotta E. , Peluso R. 
Published: July 2021

Abstract
Geothermal and volcanic systems are prone to gravity-induced slope instability at different scales. Endogenous magmatic, hydrothermal and seismic forcings can significantly modify rock mass rheology and perturb the local stress field and gravitational equilibrium, inducing shallow or slope-scale processes. The island of Ischia, which is part of the Phlegrean Volcanic District (Italy), is a remarkable example of this kind of complex interacting system. This study focuses on monitoring the hydrothermal system located beneath the ongoing slope-scale deformation, which involves Mt Nuovo (the western part of Mt Epomeo) and is a complementary effect of the resurgence of an ancient caldera. Debris and rock avalanches have affected the slopes of this volcanic island, in response to the renewal of volcanic activity and caldera resurgence. Large parts of the corresponding mass-wasting deposits overlay the most active areas of the Ischia hydrothermal system, where ongoing slope-scale gravity-driven deformation owing to a mass rock creep (MRC) process is still evolving. To investigate possible relations between the perturbing shallow hydrothermal system and the MRC process, thermal monitoring of selected groups of fumarolic emissions located in several portions of the deforming sector has been carried out since 2008 on a monthly basis by means of direct (thermal probes) and remote sensing (IR-thermography) techniques. Thermal monitoring of specific fumaroles reveals a peculiar seasonal trend characterized by a delayed inverse correlation with rainy periods and a short-term pulsating response to dry stages. The fumaroles also appear spatially correlated to the presence of MRC-related structures involving volcanic slopes. According to the measured thermal data, a conceptual model of the thermal interactions within the Mt Nuovo slope is provided, framing the potential role of thermal actions in accelerating the deformation process. In this view, possible chain effects, owing to magmatic or hydrothermal renovation, are depicted, delineating the most severe multihazard scenario consisting of an accelerating evolution of the MRC process towards paroxysmal collapse.