bluuebunny/crossref_metadata_2025_split huggingface dataset:
Production, characterization and mechanical properties of Solid form geopolymeric binder- via mechanochemical route using class-F fly ash.
Authors: KUSHWAH SHAILESH , Mudgal Manish , Chouhan Ramesh Kumar , Srivast Avanish Kumar 
Published: February 2021

Abstract
Here, we developed Solid form geopolymeric binder, the reaction between aluminosilicate material and dry chemicals i.e. fly ash with sodium hydroxide and sodium metasilicate by ball milling for 6 hrs. to make in solid form.. Mechanochemical ball milling of raw material causes a solid-state reaction between raw materials and form solid form geopolymeric precursor which requires the addition of water to make Solid form geopolymeric binder. This geopolymer has been characterized by different characterizing techniques, such as XRD, FTIR, FESEM, and EDAX, and evaluated for compressive, flexure, and split tensile strength. In our results, we had achieved a compressive strength of 55.4 MPa, flexure strength of 5.38 MPa, and split tensile strength of 3.9 MPa after 28 days of testing. Solid form geopolymers have overcome the handling and hazards difficulties, which is associated with the conventional route. So now it is possible to use Solid form geopolymeric binder as general building construction and in-situ application for construction industry, which were limited to precast construction work by conventional geopolymer route.
Evaluation of the severe preeclampsia classification criterion for antiphospholipid syndrome in a study of 40 patients
Authors: Larosa Maddalena , Guern Veronique Le , Morel Nathalie , Belhocine Mériem , Ruffatti Amelia , Martin-Silva Nicolas , Paule Romain , Mouthon Luc , Dreyfus Michel , Piette Jean-Charles , Souchaud-Debouverie Odile , Deneux-Tharaux Catherine , Guettrot-Imbert Gaelle , Tsatsaris Vassilis , Pannier-Metzger Emmanuelle , Murarasu Anne , Doria Andrea , Costedoat-Chalumeau Nathalie 
Published: February 2021

Abstract
Background

The criteria for antiphospholipid syndrome (APS) include severe preeclampsia and/or placental insufficiency leading to preterm delivery before 34 weeks of gestation, but this APS manifestation has been rarely studied. Thus, we reported a large series of severe preeclampsia occurred in patients with APS.
Methods

We retrospectively analysed data of APS women (Sydney criteria) who experienced severe preeclampsia with delivery before 34 weeks' gestation between 2000 and 2017 at five French internal medicine departments and one Italian rheumatology unit.
Results

The 40 women had a mean age of 30.5 ± 4.6 years at their first episode of preeclampsia; 21 were nulligravid (52.5%), 12 (30%) had already been diagnosed with APS, and 21 (52.5%) had a triple-positive antiphospholipid (aPL) antibody test.
Anti-Inflammatory Effect of Gold Nanoparticles Supported on Metal Oxides&nbsp;
Authors: Fujita Takeshi , ZYSMAN Maéva , Elgrabli Dan , Murayama Toru , Haruta Masatake , Lanone Sophie , Ishida Tamao , Boczkowski Jorge 
Published: February 2021

Abstract
Gold (Au) can be deposited as nanoparticles (NPs) smaller than 10 nm in diameter on a variety of metal oxide (MOx) NPs. Au/MOx NPs have high catalytic performance and selective oxidation capacity which could have implications in terms of biological activity, and more specifically in modulation of the inflammatory reaction. Therefore, the aim of this study was to examine the effect of Au/TiO2, Au/ZrO2 and Au/Ce/O2 on viability, phagocytic capacity and inflammatory profile (TNF-α and IL-1β secretion) of murine macrophages. The most important result of this study is an anti-inflammatory effect of Au/MOx NPs depending on the MOx nature with particle internalization and no alteration of cell viability and phagocytosis. The effect was dependent on the MOx NPs chemical nature (Au/TiO2> Au/ZrO2> Au/CeO2 if we consider the number of cytokines whose concentration was reduced by the NPs), and on the inflammatory mediator considered. The effect of Au/TiO2 NPs was not related to Au NPs size (at least in the case of Au/TiO2 NPs in the range of 3-8 nm). To the best of our knowledge, this is the first demonstration of an anti-inflammatory effect of Au/MOx NPs.
Decision-Support Systems For Ambulatory Care, Including Pandemic Requirements: Using Mathematically Optimized Solutions
Authors: Leithäuser Neele , Adelhütte Dennis , Braun Kristin , Büsing Christina , Comis Martin , Gersing Timo , Johann Sebastian , Koster Arie M.C.A. , Krumke Sven O. , Liers Frauke , Schmidt Eva , Schneider Johanna , Streicher Manuel , Tschuppik Sebastian , Wrede Sophia 
Published: February 2021

Abstract
Background: The healthcare sector poses many strategic, tactic and operational planning questions. Due to the historically grown structures, planning is often locally confined and much optimization potential is foregone. Methods: We implemented optimized decision-support systems for ambulatory care for four different real-world case studies that cover a variety of aspects in terms of planning scope and decision support tools. All are based on interactive cartographic representations and are being developed in cooperation with domain experts. The planning problems that we present are the problem of positioning centers for vaccination against Covid-19 (strategical) and emergency doctors (strategical/tactical), the out-of-hours pharmacy planning problem (tactical), and the route planning of patient transport services (operational). For each problem, we describe the planning question, give an overview of the mathematical model and present the implemented decision support application. Results: Mathematical optimization can be used to model and solve these planning problems. However, in order to convince decision-makers of an alternative solution structure, mathematical solutions must be comprehensible and tangible. Appealing and interactive decision-support tools can be used in practice to convince public health experts of the benefits of an alternative solution. The more strategic the problem and the less sensitive the data, the easier it is to put a tool into practice. Conclusions: Exploring solutions interactively is rarely supported in existing planning tools. However, in order to bring new innovative tools into productive use, many hurdles must be overcome.
Synthesis and Characterization of Silica-Lead Sulfide Core Shell Nanospheres For Applications in Optoelectronic Devices
Authors: Romero-Jaime Anderson Klay , Acosta-Enríquez Milka del Carmen , Vargas-Hernández Diana , Tánori-Córdova Judith Celina , Pineda-León Horacio Antolín , Castillo Santos Jesús 
Published: February 2021

Abstract
Nanoscale miniaturization of chalcogenides semiconductors, such as lead sulfide (galena), can generate interesting quantum confinement effects in the field of optoelectronic applications. At this work, a process in order to obtain SiO2 nanospheres coated with Galena, as the denominated core-shell system, is developed, this process it is based in Stöber’s method, where only the magnetic stirring was replaced by an ultrasonic bath, to achieve well rounded, and highly stable silica nanoparticles with diameters average of 70 nm. The PbS shell cover presents a thickness of 10 nm around. Nanostructures chemical composition, morphology and optical properties were determined by Transmission Electron Microscopy and UV-Vis spectroscopy, respectively. As a result, the nano shells correspond to cubic PbS, presenting some interplanar distances of 2.95 Å and 3.41 Å; this nano shell also shown a toward blue optical spectrum shift and a remarkable increase in its band gap, 3.75 eV, was obtained, compared with the PbS bulk value. The chemical composition it is studied by energy scattering spectroscopy, and X-ray photoelectron spectroscopy analyzes.
LncRNA CRNDE decreases the sensitivity of sorafenib in HCC cells via promoting ATG4B-mediated autophagy
Authors: Chen Lingxi , Sun Liangbo , Dai Xufang , Li Tao , Yan Xiaojing , Zhang Yueting , Xiao Hanxi , Shen Xiaodong , Huang Gang , Xiang Wei , Zhang Yan , Tan Dehong , Yang Shiming , Nie Yongzhan , Huang Xuequan , Lian Jiqin , He Fengtian 
Published: February 2021

Abstract
Background: Autophagy has been confirmed to be closely related to the growth and drug resistance of cancer cells, and autophagy related 4B (ATG4B) performs a crucial role in the process of autophagy. lncRNA CRNDE (colorectal neoplasia differentially expressed) promotes the growth of hepatocellular carcinoma (HCC) cells, but it is unclear whether the tumor-promoting effect of CRNDE is associated with the regulation of ATG4B and autophagy.
Methods: The expression of CRNDE and ATG4B in HCC tissues and cells was detected by quantitative real-time PCR (qPCR) and Western blot. The effect of CRNDE on autophagy of HCC cells was examined by fluorescent assay, GFP-LC3 analysis and Western blot. The relationship among CRNDE, miR-543 and ATG4B was clarified using bioinformatic analysis, qPCR, Western blot and dual-luciferase reporter assay. The effect of CRNDE on sensitivity of sorafenib in HCC cells was evaluated in vitro and in vivo by CCK-8 assay, Western blot, Hoechst staining, flow cytometry, IHC staining and TUNEL assay.
Results: CRNDE induced autophagy via upregulating ATG4B in HCC cells. Mechanistically, CRNDE enhanced the stability of ATG4B mRNA by suppressing miR-543, leading to the increase of ATG4B expression and autophagy in HCC cells. Moreover, sorafenib dramatically elevated CRNDE and ATG4B as well as autophagy. Knockdown of CRNDE significantly sensitized HCC cells to sorafenib in vitro and in vivo .
Conclusion: The study has revealed the presence of “CRNDE/ATG4B/autophagy” pathway which alleviates the sensitivity of sorafenib in HCC cells, suggesting that this pathway may serve as a novel target to improve the killing effect of sorafenib in HCC treatment.
Visceral Adiposity index and atherogenic index of plasma as reliable indices to prediction of cardiovascular diseases in adults: A Cross-Sectional analysis from the Iranian RaNCD Cohort Data
Authors: Hamzeh Behrooz , Pasdar Yahya , Mirzaei Narmin , Faramani Roya Safari , Najafi Farid , Shakiba Ebrahim , Darbandi Mitra 
Published: February 2021

Abstract
Background: Visceral Adiposity index (VAI) and atherogenic index of plasma (AIP) are relatively new indicators for predicting Non-Communicable disease (NCDs). The aim of this study was to assess the association AIP and VAI with risk of developing cardiovascular diseases (CVDs) in adults.Materials: This was a cross-sectional analysis conducted on 7362 individuals aged 35 to65 years participated in Ravansar Non-Communicable Diseases (RaNCD) cohort study. AIP was calculated based on the value of TG and HDL-C. VAI was calculated using BMI (Body mass index), waist circumference (WC), serum triglyceride, and High density lipoprotein cholesterol (HDL-C).All participants were stratified into three groups based on AIP and VAI tertiles. Simple and multiple logistic regression models were applied to assess the effect of these indices on CVDs.Results: The mean of AIP and VAI was significantly higher in CVDs patients than in non-CVDs (P < 0.001). After adjusting for age, sex hypertension, hyperlipidemia and smoking the risk of CVDs in the second and third tertile of AIP were 1.27 (95% CI: 1.06, 1.52) and 1.63 (95% CI: 1.31, 2.03) times higher comparing to the first tertile, respectively. Risk of CVDs in the second and third tertile of VAI were1.41 (95% CI: 1.18, 1.70) and 1.98 (95% CI: 1.60, 2.46) times higher than the first tertile, respectively; while adjusting for age, sex, hypertension and dyslipidemia.Conclusion: According to the findings, AIP and VAI were positively associated with CVDs in adults. Therefore, AIP and VAI can be useful in identifying high-risk subgroups of CVDs in general population.
Pre- versus postnatal initial colonization of healthy neonates’ colon ecosystem by the enterobacterium Escherichia coli
Authors: Al-Balawi Mohammad , Morsy Fatthy 
Published: February 2021

Abstract
Background

Human colon is a microbial ecosystem where its initial bacterial colonization in neonates is important step for establishing a beneficial microbiota for the body health. This study investigated occurrence of viable culturable Escherichia coli in first day meconium versus subsequent days stool to explore the prenatal versus postnatal initial colonization of colon by Escherichia coli in healthy neonates.
Methods

E. coli occurrence was conducted on eosin methylene blue agar followed by morphological and biochemical characterizations and phylogenetic analysis of 16S rRNA encoding gene.
Results

Viable culturable E. coli was not detected in meconium of healthy male and female neonates of normal birth or cesarean section surgical delivery. Neonates of surgical delivery showed no E. coli colonization at also 2nd and 3rd day confirming a postnatal colonization of colon by this enterobacterium. E. coli initial colonization in colon of normal birth neonates occur at 2nd day which can be attributed to inoculation from vaginal canal during delivery which in comparison to neonates of surgical delivery infers that the bacterium is not originally found in meconium.
Conclusions

This study suggests no viability of meconium microbiome in healthy neonates possibly due to antimicrobial action in the prenatal colon’s meconium protecting babies’ gut from infection during delivery.
Title: Cardiac MRI derived radiomics based machine learning (ML) models in identifying pulmonary hypertension (PH)- Impact of segmentation, radiomics side experiments and DAFIT approach on model performance
Authors: Priya Sarv , Aggarwal Tanya , Ward Caitlin , Bathla Girish , Jacob Mathews , Gerke Alicia , Hoffman Eric A. , Nagpal Prashant 
Published: February 2021

Abstract
Side experiments are performed on radiomics models to improve their reproducibility. We measure the impact of myocardial masks, radiomic side experiments and data augmentation for information transfer (DAFIT) approach to differentiate patients with and without pulmonary hypertension (PH) using cardiac MRI (CMRI) derived radiomics. Feature extraction was performed from the left ventricle (LV) and right ventricle (RV) myocardial masks using CMRI in 82 patients (42 PH and 40 controls). Various side study experiments were evaluated: Original data without and with intraclass correlation (ICC) feature-filtering and DAFIT approach (without and with ICC feature-filtering). Multiple machine learning and feature selection strategies were evaluated. Primary analysis included all PH patients with subgroup analysis including PH patients with preserved LVEF (≥ 50%). For both primary and subgroup analysis, DAFIT approach without feature-filtering was the highest performer (AUC 0.957–0.958). ICC approaches showed poor performance compared to DAFIT approach. The performance of combined LV and RV masks was superior to individual masks alone. There was variation in top performing models across all approaches (AUC 0.862–0.958). DAFIT approach with features from combined LV and RV masks provide superior performance with poor performance of feature filtering approaches. Model performance varies based upon the feature selection and model combination.
Characterization and Anticancer Effects of Folate Targeted Inotodiol Liposome From Inonotus Obliquus (Chaga Mushroom)
Authors: Lu Yangpeng , Gao Xudong , Chen Zhongqin , Xue Zihan , Jia Yanan , Li Nannan , Wang Yajie , Chen Haixia 
Published: February 2021

Abstract
Inotodiol, one tetracyclic triterpenoid isolated from inonotus obliquus (Chaga mushroom) possess excellent anticancer, antioxidant and anti-inflammatory activities, however it has not been applied to medical use due to its low solubility and low bioavailability. Liposome as a good nanodrug carrier with EPR and good biocompatibility has received much research attention. To improve the solubility and bioavailability of IOP, we prepared inotodiol liposomes (IOP-Lps) and folic-acid targeting IOP liposome (FA-IOP-Lps) by ultrasonic method, and their particle size, morphology, zeta potential, entrapment efficiency (EE) and drug loading rate (DL) were characterized by DLS, TEM, FT-IR and HPLC respectively. Their in vitro cytotoxicity of human cervical cancer cells HeLa, human liver cancer cells HepG2 and human breast cancer cells MCF-7 were assessed using the MTT assay. The results showed that IOP-Lps and FA-IOP-Lps possess significant anticancer effects. The results of TEM, FT-IR and DLS confirmed the formation of liposome. The particle size of IOP-Lps were 201.07±6.47 nm and ζ-potential of -50.2±0.5 mV, FA-IOP-Lps 224.33±1.86 nm and ζ-potential of -51.2±0.3 mV, the EE of IOP-Lps and FA-IOP-Lps were 79.14% and 77.33%, respectively. IOP-Lps and FA-IOP-Lps could selectively kill HeLa, HepG2 and MCF-7 cancer cells while nontoxic to normal L02 cells. This is the first study to give out in vitro information of inotodiol’ s anticancer effects based on nanocarriers. Besides, this drug delivery system is of good sustained release and targeted delivery effects to promote the utilization of both inotodiol and other natural hydrophobic compounds in target treatment of cancers.
Study on Tidal Volume According to the 4-Point Sealing Forces of Bag-Valve-Mask : An Adult Respiratory Arrest Simulator Based Prospective, Descriptive Study
Authors: Uhm Dongchoon , Kim Ajung 
Published: February 2021

Abstract
Background

For adequate ventilation during bag-valve-mask ventilation, rescuers should ensure a proper mask seal using the one-handed or two-handed technique. Little is known how much sealing forces of bag-valve-mask are needed for adequate ventilation. This study aimed to explored the effect of the 4-point sealing forces of a bag-valve-mask on tidal volume while using the one-handed technique, focusing on the moderating effect of C length ( C length is the distance from the thumb to index finger in the C shape of in the one-hand EC grip).
Methods

This was a prospective, descriptive simulation study design. Convenience sample of 125 undergraduate paramedic students from two universities was participated. A self-reported questionnaire was used to collect subject data. Tidal volumes, 4-point sealing forces of the mask, peak pressure, and C length of the C shape in the one-hand EC grip, were measured using the mechanical lung model under a simulated adult respiratory arrest. Hierarchical regression analysis was used to determine the moderating effect of C length on tidal volume in bag-valve-mask ventilation.
Results

The average C length, peak pressure and tidal volume were 7.54 (± 1.85) cm, 11.62 (± 5.40) cmH2O, and 321.66 (± 135.18) mL, respectively. The average range of the 4-point sealing forces were 0.03–0.69 newton. The apex sealing force was the weakest point among the 4-point sealing forces. Hierarchical regression analysis demonstrated that tidal volume accounted for 62.7% of the variance by C length, peak pressure, and apex sealing force during bag-valve-mask ventilation (F = 9.676, p < .001). C length moderated the effect of apex sealing force and peak pressure on tidal volume. That is, the more peak pressure and apex sealing force, the more the tidal volume, and the longer the C length, the more the tidal volume.
Conclusion

We developed effective advice that can be adopted in clinical practice without side effects as the first simulation study measuring the 4-point sealing forces during bag-valve-mask ventilation, as well as underpin continuous retraining and assessment that focus on individual physical characteristics, such as C length and bag-valve-mask sealing force.
The Impact of COVID-19: A Comparison of Nurses’ Turnover Intentions Before and During the COVID-19 Pandemic in Qatar
Authors: Nashwan Abdulqadir J. , Abujaber Ahmad A. , Villar Ralph C. , Nazarene Ananth , Al-Jabry Mahmood M. 
Published: February 2021

Abstract
Background

Several research studies have been conducted to have a better understanding of the reasons behind the intention of nurses to leave their jobs. To date, few studies have been conducted to explore how COVID-19 contributes to nurses' turnover intentions. This study aims at exploring nurses’ turnover intentions before COVID-19 and during COVID-19.
Methods

A cross-sectional study was conducted using the Turnover Intention Scale (TIS-6), where a convenience sample of 512 registered nurses participated from Hamad Medical Corporation (the largest healthcare provider in Qatar) from August to September 2020.
Results

A total of 512 nurses were included in the final analysis. The majority were between 31–40 years (61.5%), 67.6% females, 76.4% married, 79.9% had a BSN, 43% have less than 5 years of experience, 60.4% have worked in COVID-19 designated facilities. There was a significant difference between turnover intentions before and during COVID-19; the turnover intentions were higher during COVID-19 compared to before COVID-19 (p < 0.01).
Conclusion

Nurses in Qatar have higher turnover intentions during COVID-19 compared to before COVID-19. The participants’ characteristics and stress levels are playing a major role in nurses’ decision to leave during COVID-19. Understanding the factors that contribute to the turnover intentions is crucial for workforce planning, especially during pandemics. Addressing the factors associated with turnover intentions will positively be reflected in nurses’ well-being and turnover intentions.
Sox14 is essential for initiation of interneuron differentiation in the chick spinal cord
Authors: Katsuyama Taiki , Kadoya Minori , Shirai Manabu , Sasai Noriaki 
Published: February 2021

Abstract
The neural tube comprises several different types of progenitors and postmitotic neurons that coordinately act with each other to play integrated functions. Its development consists of two phases: proliferation of progenitor cells and differentiation into postmitotic neurons. How progenitor cells differentiate into each corresponding neuron is an important question for understanding the mechanisms of neuronal development. Here we introduce one of the Sox transcription factors, Sox14, which plays an essential role in the promotion of neuronal differentiation. Sox14 belongs to the SoxB subclass and its expression starts in the progenitor regions before neuronal differentiation is initiated at the trunk level of the neural tube. After neuronal differentiation is initiated, Sox14 expression gradually becomes confined to the V2a region of the neural tube, where Chx10 is co-expressed. Overexpression of Sox14 restricts progenitor cell proliferation. Conversely, the blockade of Sox14 expression by the RNAi strategy inhibits V2a neuron differentiation and causes expansion of the progenitor domain. We further found that Sox14 acted as a transcriptional activator. Taken together, Sox14 acts as a modulator of cell proliferation and an initiator protein for neuronal differentiation in the intermediate region of the neural tube.