bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decoding Neural Representations of Affective Scenes in Retinotopic Visual Cortex
Authors: Bo Ke , Yin Siyang , Liu Yuelu , Hu Zhenhong , Meyyappan Sreenivasan , Kim Sungkean , Keil Andreas , Ding Mingzhou 
Published: January 2021

Abstract
The perception of opportunities and threats in complex visual scenes represents one of the main functions of the human visual system. The underlying neurophysiology is often studied by having observers view pictures varying in affective content. It has been shown that viewing emotionally engaging, compared with neutral, pictures (1) heightens blood flow in limbic, frontoparietal, and anterior visual structures and (2) enhances the late positive event-related potential (LPP). The role of retinotopic visual cortex in this process has, however, been contentious, with competing theories predicting the presence versus absence of emotion-specific signals in retinotopic visual areas. Recording simultaneous electroencephalography–functional magnetic resonance imaging while observers viewed pleasant, unpleasant, and neutral affective pictures, and applying multivariate pattern analysis, we found that (1) unpleasant versus neutral and pleasant versus neutral decoding accuracy were well above chance level in retinotopic visual areas, (2) decoding accuracy in ventral visual cortex (VVC), but not in early or dorsal visual cortex, was correlated with LPP, and (3) effective connectivity from amygdala to VVC predicted unpleasant versus neutral decoding accuracy, whereas effective connectivity from ventral frontal cortex to VVC predicted pleasant versus neutral decoding accuracy. These results suggest that affective scenes evoke valence-specific neural representations in retinotopic visual cortex and that these representations are influenced by reentry signals from anterior brain regions.
Evaluation of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission Mitigation Strategies on a University Campus Using an Agent-Based Network Model
Authors: Goyal Ravi , Hotchkiss John , Schooley Robert T , De Gruttola Victor , Martin Natasha K 
Published: January 2021

AbstractUniversities are faced with decisions on how to resume campus activities while mitigating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) risk. To provide guidance for these decisions, we developed an agent-based network model of SARS-CoV-2 transmission to assess the potential impact of strategies to reduce outbreaks. The model incorporates important features related to risk at the University of California San Diego. We found that structural interventions for housing (singles only) and instructional changes (from in-person to hybrid with class size caps) can substantially reduce the basic reproduction number, but masking and social distancing are required to reduce this to at or below 1. Within a risk mitigation scenario, increased frequency of asymptomatic testing from monthly to twice weekly has minimal impact on average outbreak size (1.1–1.9), but substantially reduces the maximum outbreak size and cumulative number of cases. We conclude that an interdependent approach incorporating risk mitigation, viral detection, and public health intervention is required to mitigate risk.
Olfactory Cues From Host- and Non-host Plant Odor Influence the Behavioral Responses of AdultDrosophila suzukii(Diptera: Drosophilidae) to Visual Cues
Authors: Bolton L Grant , Piñero Jaime C , Barrett Bruce A 
Published: January 2021

AbstractWhile trapping methods for Drosophila suzukii Matsumura (Diptera: Drosophilidae) have typically relied on fermentation volatiles alone or in association with a visual stimulus, the relative contribution of visual and olfactory stimuli to the food- and host-seeking behavior of D. suzukii is poorly understood. This study quantified the type of response exhibited by male and female D. suzukii to color and the effects that volatiles (fermentation, fresh fruit, and leaf) exert on the outcome. Seven-, four- and two-choice assays were used to quantify interactions between visual and olfactory cues. When no volatiles were present in a seven-choice assay, D. suzukii preferred red, black, and green pigments. Black and red were preferred when yeast odors were present, and black alone was the most attractive color when blueberry odor was present. A strawberry leaf terpenoid, β-cyclocitral, seemed to have overridden the flies’ response to color. In four-choice assays, blueberry odor was more likely to interact synergistically with color than yeast or β-cyclocitral. This study demonstrates that D. suzukii modulates the response to multimodal sensory modalities (vision and olfaction) depending, to some extent, on the type of olfactory stimuli. Our findings also provide insight into the relative importance of vision as a function of odor quality in this invasive species.
Electrocardiogram machine learning for detection of cardiovascular disease in African Americans: the Jackson Heart Study
Authors: Pollard James D , Haq Kazi T , Lutz Katherine J , Rogovoy Nichole M , Paternostro Kevin A , Soliman Elsayed Z , Maher Joseph , Lima João A C , Musani Solomon K , Tereshchenko Larisa G 
Published: January 2021

Abstract

Aims
Almost half of African American (AA) men and women have cardiovascular disease (CVD). Detection of prevalent CVD in community settings would facilitate secondary prevention of CVD. We sought to develop a tool for automated CVD detection.

Methods and results
Participants from the Jackson Heart Study (JHS) with analysable electrocardiograms (ECGs) (n = 3679; age, 62 ± 12 years; 36% men) were included. Vectorcardiographic (VCG) metrics QRS, T, and spatial ventricular gradient vectors’ magnitude and direction, and traditional ECG metrics were measured on 12-lead ECG. Random forests, convolutional neural network (CNN), lasso, adaptive lasso, plugin lasso, elastic net, ridge, and logistic regression models were developed in 80% and validated in 20% samples. We compared models with demographic, clinical, and VCG input (43 predictors) and those after the addition of ECG metrics (695 predictors). Prevalent CVD was diagnosed in 411 out of 3679 participants (11.2%). Machine learning models detected CVD with the area under the receiver operator curve (ROC AUC) 0.69–0.74. There was no difference in CVD detection accuracy between models with VCG and VCG + ECG input. Models with VCG input were better calibrated than models with ECG input. Plugin-based lasso model consisting of only two predictors (age and peak QRS-T angle) detected CVD with AUC 0.687 [95% confidence interval (CI) 0.625–0.749], which was similar (P = 0.394) to the CNN (0.660; 95% CI 0.597–0.722) and better (P &lt; 0.0001) than random forests (0.512; 95% CI 0.493–0.530).

Conclusions
Simple model (age and QRS-T angle) can be used for prevalent CVD detection in limited-resources community settings, which opens an avenue for secondary prevention of CVD in underserved communities.
Temporary Relief of Pay-for-Delay: The ECJ as Specifically Different Antidepressant
Authors: Gschwindt Daniela 
Published: January 2021

Abstract
Pay-for-delay agreements are increasingly scrutinised and sanctioned in the European Union (EU). The state of play so far has only made it possible to analyse such agreements as restrictions of competition by object under Art. 101(1) of the Treaty on the Functioning of the European Union (TFEU) and in some cases as abuses of a dominant position under Art. 102 TFEU. At the beginning of this year, the European Court of Justice (ECJ) gave its first ruling on this issue. The Generics judgment (C-307/18) deepens the reasoning and defined line of the General Court (EGC) and the Commission and deals with fundamental questions of competition law. To this end, the Court has extended the existing investigation criteria. Although the judgment consolidates the status of pay-for-delay, it fails to resolve important aspects and leaves only losers. This comment takes the ECJ’s decision in Generics as an opportunity to analyse pay-for-delay agreements in the EU from a critical perspective.
Cutting out the camel-like knees of St. James: the de viris illustribus tradition in the twelfth-century renaissance
Authors: Byrne Philippa 
Published: January 2021

Abstract
This article examines the revival of the de viris illustribus genre in the twelfth century. These catalogues of the most important Christian authors were modelled on a template created in late antiquity by Jerome, but adopted new attitudes to what constitutes distinguished Christian literary activity. They regard the editing, collecting, and re-ordering of texts as equal to the composition of new works, and recognize legal codification as a noteworthy activity. As such, they represent the broadening out of a Latin Christian literary canon. These texts complicate our ideas about the relationship between ‘authority’ and ‘amplification’ in the twelfth-century renaissance.
Evaluation of a novel animal milk oligosaccharide biosimilar: macronutrient digestibility and gastrointestinal tolerance, fecal metabolites, and fecal microbiota of healthy adult dogs and in vitro genotoxicity assays
Authors: Lee Anne H , Vidal Sara , Oba Patrícia M , Wyss Romain , Miao Yong , Adesokan Yemi , Swanson Kelly S 
Published: January 2021

Abstract
Milk oligosaccharides (MO) are bioactive compounds in mammalian milk that provide health benefits to neonates beyond essential nutrients. GNU100, a novel animal MO biosimilar, was recently tested in vitro, with results showing beneficial shifts in microbiota and increased short-chain fatty acid (SCFA) production, but other effects of GNU100 were unknown. Three studies were conducted to evaluate the safety, palatability, and gastrointestinal (GI) tolerance of GNU100. In study 1, the mutagenic potential of GNU100 was tested using a bacterial reverse mutation assay and a mammalian cell micronucleus test. In study 2, palatability was assessed by comparing diets containing 0% vs. 1% GNU100 in 20 adult dogs. In study 3, 32 adult dogs were used in a completely randomized design to assess the safety and GI tolerance of GNU100 and explore utility. Following a 2-wk baseline, dogs were assigned to one of four treatments and fed for 26 wk: 0%, 0.5%, 1%, and 1.5% GNU100. On weeks 2, 4, and 26, fresh fecal samples were collected to measure stool quality, immunoglobulin A, and calprotectin, and blood samples were collected to measure serum chemistry, inflammatory markers, and hematology. On weeks 2 and 4, fresh fecal samples were collected to measure metabolites and microbiota. On week 4, total feces were collected to assess apparent total tract macronutrient digestibility. Although revertant numbers were greater compared with the solvent control in tester strain WP2uvrA(pKM101) in the presence of metabolic activation (S9) in the initial experiment, they remained below the threshold for a positive mutagenic response in follow-up confirmatory tests, supporting that GNU100 is not mutagenic. Similarly, no cytotoxicity or chromosome damage was observed in the cell micronucleus test. The palatability test showed that 1% GNU100 was strongly preferred (P &lt; 0.05; 3.6:1 consumption ratio) over the control. In study 3, all dogs were healthy and had no signs of GI intolerance or illness. All diets were well accepted, and food intake, fecal characteristics, metabolite concentrations, and macronutrient digestibilities were not altered. GNU100 modulated fecal microbiota, increasing evenness and Catenibacterium, Megamonas, and Prevotella (SCFA producers) and reducing Collinsella. Overall, the results suggest that GNU100 is palatable and well-tolerated, causes no genotoxicity or adverse effects on health, and beneficially shifts the fecal microbiota, supporting the safety of GNU100 for the inclusion in canine diets.
Synthetic utility of oxygenases in site-selective terpenoid functionalization
Authors: Renata Hans 
Published: January 2021

Abstract
Terpenoids are one of the largest classes of natural products whose members possess a wide variety of biological activities. With several exceptions, scalable production of complex terpenoids with either purely biological or chemical methods still remains a major challenge. However, recent efforts to combine the two approaches in chemoenzymatic synthesis hold tremendous promise to address this challenge. Central to this paradigm is the development of useful biocatalytic methods, such as regioselective C–H oxidation, for terpene modifications. This review highlights recent applications of biocatalytic hydroxylation for site-selective modification of terpenoids.
Soybean Gall Midge (Diptera: Cecidomyiidae), a New Species Causing Injury to Soybean in the United States
Authors: McMechan Anthony J , Hodgson Erin W , Varenhorst Adam J , Hunt Thomas , Wright Robert , Potter Bruce 
Published: January 2021

AbstractThe soybean gall midge (Resseliella maxima Gagné) was recently identified as a new species causing injury to soybean in the Midwestern United States. Although this insect was only recently identified, it has likely been present in soybean fields for at least the last 8 yr based on anecdotal reports. The soybean gall midge has historically been observed late in the season on soybean plants that were believed to have been previously compromised by a plant pathogen or mechanical damage with little to no concern for economic losses. In late June 2018, dead and dying plants were found to be associated with the soybean gall midge across four midwestern states. The distribution of plant injury in the field, larval feeding within the stem, and timing of infestation indicate that it is likely an important pest of soybean. Yield losses in soybean gall midge infested fields can be up to 100% for the first 30 meters from the field edge, with losses of 17–31% further into the field. The rapid development of the soybean gall midge as an important pest of soybean has left large gaps in the knowledge necessary to develop an integrated pest management program.
Reinertia, a New Subgenus of the Genus Aedes Meigen and Its Type Species Aedes (Reinertia) suffusus (Diptera: Culicidae), Newly Recorded From Bhutan
Authors: Somboon Pradya , Phanitchakun Thanari , Saingamsook Jassada , Namgay Rinzin , Harbach Ralph E 
Published: January 2021

Abstract
A new subgenus, Reinertia Somboon, Namgay & Harbach, of the genus Aedes Meigen and its type species, Ae. suffusus Edwards, are described from specimens reared from larvae and pupae found in a tree hole in Bhutan. The scutum of the adults is mostly covered with narrow pale falcate scales. The proboscis, maxillary palpus, tibiae, and tarsi are dark-scaled. The gonocoxite of the male genitalia bears a unique setose basomesal sclerite. The larva closely resembles larvae of the subgenus Downsiomyia Vargus in having setae 4–6-C with numerous branches and inserted more or less on level with seta 7-C, abdominal seta 12-I is present and the comb is composed of 6–10 spine-like scales arranged in an irregular row. Surprisingly, Reinertia shares features of the adult habitus, male genitalia, and larva with the Palearctic subgenus Dahliana Reinert, Harbach & Kitching. However, in phylogenetic analyses of the mitochondrial COI gene of species representing 38 subgenera of Aedes and six other genera of the tribe Aedini Neveu-Lemaire, Reinertia was not associated with Dahliana or Downsiomyia. In both maximum likelihood and Bayesian analyses of the data, Ae. suffusus was recovered as the weakly supported sister of a clade composed of five species of the subgenus Protomacleaya Theobald. In the absence of strong support, and because Protomacleaya is an unnatural group of species that resemble each other phenetically by virtue of what they lack, Ae. suffusus cannot be placed in the subgenus Protomacleaya. Thus, the morphological and molecular data attest the uniqueness of Ae. suffusus and its recognition as a monobasic subgeneric lineage.
Abundance of Ticks (Acari: Ixodidae) and Presence ofRickettsiaandAnaplasmain Ticks Infesting Domestic Animals From Northern India
Authors: Misra Brij Ranjan , Kumar Niraj , Kant Rajni , Deval Hirawati , Singh Rajeev , Pandey Ashok Kumar , Behera Sthita Pragnya , Bondre Vijay P 
Published: January 2021

AbstractRickettsia and Anaplasma are bacteria that can be transmitted by hematophagous arthropods such as ticks infesting animals in close proximity to humans. The main objective of the present study was to investigate abundance of common tick species infesting domestic animals and presence of Rickettsia and Anaplasma in tick populations. Adult ticks were collected from domestic animals in rural areas and screened by molecular detection of bacterial DNA for these two genera of bacteria. A total of 1,778 adult ixodid tick specimens were collected from 200 cattle, 200 buffaloes, 200 goats, and 40 dogs. The collection consisted of four species of ixodid ticks, Rhipicephalus (Boophilus) microplus (Canestrini) (83.8%), Hyalomma kumari (Sharif) (7.1%), Rhipicephalus sanguineus (Latreille) (6.4%), and Dermacentor auratus (Supino) (2.7%) infesting the domestic animals. The prevalence of all the collected tick species was highest in the month of October. Anaplasma spp. was the most frequently identified bacteria (3.3%) in tested ticks. Of 17 positive tick pools for Anaplasma spp., 14 pools were from ticks infesting cattle, 2 pools of ticks collected from buffalo, and the remaining pool were ticks infesting a goat at the time of collection. Although 1.6% tick pools of R. microplus collected from cattle tested positive for Rickettsia spp., present investigation provides evidence of the most prevalent ixodid ticks infesting domestic animals and the presence of obligate intracellular bacteria, Rickettsia and Anaplasma, in these ticks collected in the Gorakhpur division of Northern India.
Teicoplanin Therapeutic Drug Monitoring and Treatment Outcomes in Children With Gram-Positive Infections
Authors: Loane Georgia , Gwee Amanda 
Published: January 2021

Abstract
This is a retrospective audit of teicoplanin dosing, drug-level monitoring, and outcomes in 29 children who received 31 courses of teicoplanin. Our study of noncritically ill children showed that the majority (35/43, 81%) of trough concentrations were within the therapeutic range (10-30 mg/L) contrasting previous studies in children. Overall, 21 of the 24 (88%) children with Gram-positive infections achieved cure.
Phytosulfokine (PSK) precursor processing by subtilase SBT3.8 and PSK signaling improve drought stress tolerance in Arabidopsis
Authors: Stührwohldt Nils , Bühler Eric , Sauter Margret , Schaller Andreas 
Published: January 2021

Abstract
Increasing drought stress poses a severe threat to agricultural productivity. Plants, however, have evolved numerous mechanisms to cope with such environmental stress. Here we report that the stress-induced production of a peptide signal contributes to stress tolerance. The expression of phytosulfokine (PSK) peptide precursor genes, and transcripts of three subtilisin-like serine proteases, SBT1.4, SBT3.7, and SBT3.8, were found to be up-regulated in response to osmotic stress. Stress symptoms were more pronounced in sbt3.8 loss-of-function mutants and could be alleviated by PSK treatment. Osmotic stress tolerance was improved in plants overexpressing the PSK1 precursor (proPSK1) or SBT3.8, resulting in higher fresh weight and improved lateral root development in transgenic plants compared with wild-type plants. We further showed that SBT3.8 is involved in the biogenesis of the bioactive PSK peptide. ProPSK1 was cleaved by SBT3.8 at the C-terminus of the PSK pentapeptide. Processing by SBT3.8 depended on the aspartic acid residue directly following the cleavage site. ProPSK1 processing was impaired in the sbt3.8 mutant. The data suggest that increased expression of proPSK1 in response to osmotic stress followed by the post-translational processing of proPSK1 by SBT3.8 leads to the production of PSK as a peptide signal for stress mitigation.
The massive M31 cluster G1: detailed chemical abundances from integrated light spectroscopy★
Authors: Sakari Charli M , Shetrone Matthew D , McWilliam Andrew , Wallerstein George 
Published: January 2021

ABSTRACT
G1, also known as Mayall II, is one of the most massive star clusters in M31. Its mass, ellipticity, and location in the outer halo make it a compelling candidate for a former nuclear star cluster. This paper presents an integrated light abundance analysis of G1, based on a moderately high-resolution (R = 15 000) spectrum obtained with the high-resolution spectrograph on the Hobby–Eberly Telescope in 2007 and 2008. To independently determine the metallicity, a moderate-resolution (R ∼ 4000) spectrum of the Ca ii triplet lines in the near-infrared was also obtained with the Astrophysical Research Consortium’s 3.5-m telescope at Apache Point Observatory. From the high-resolution spectrum, G1 is found to be a moderately metal-poor cluster, with $[\rm {Fe/H}]~=~-0.98\pm 0.05$. G1 also shows signs of α-enhancement (based on Mg, Ca, and Ti) and lacks the s-process enhancements seen in dwarf galaxies (based on comparisons of Y, Ba, and Eu), indicating that it originated in a fairly massive galaxy. Intriguingly, G1 also exhibits signs of Na and Al enhancement, a unique signature of GCs – which suggests that G1’s formation is intimately connected with GC formation. G1’s high [Na/Fe] also extends previous trends with cluster velocity dispersion to an even higher mass regime, implying that higher mass clusters are more able to retain Na-enhanced ejecta. The effects of intracluster abundance spreads are discussed in a subsequent paper. Ultimately, G1’s chemical properties are found to resemble other M31 GCs, though it also shares some similarities with extragalactic nuclear star clusters.
Robot-Assisted Therapy for Upper Extremity Motor Impairment After Stroke: A Systematic Review and Meta-Analysis
Authors: Wu Jingyi , Cheng Hao , Zhang Jiaqi , Yang Shanli , Cai Sufang 
Published: January 2021

Abstract

Objective
The purpose of this study was to review the effects of robot-assisted therapy (RT) for improving poststroke upper extremity motor impairment.

Methods
The PubMed, Embase, Medline, and Web of Science databases were searched from inception to April 8, 2020. Randomized controlled trials that were conducted to evaluate the effects of RT on upper extremity motor impairment poststroke and that used Fugl-Meyer assessment for upper extremity scores as an outcome were included. Two authors independently screened articles, extracted data, and assessed the methodological quality of the included studies using the Physiotherapy Evidence Database (PEDro) scale. A random-effects meta-analysis was performed to pool the effect sizes across the studies.

Results
Forty-one randomized controlled trials with 1916 stroke patients were included. Compared with dose-matched conventional rehabilitation, RT significantly improved the Fugl-Meyer assessment for upper extremity scores of the patients with stroke, with a small effect size (Hedges g = 0.25; 95% CI, 0.11-0.38; I2 = 45.9%). The subgroup analysis revealed that the effects of unilateral RT, but not that of bilateral RT, were superior to conventional rehabilitation (Hedges g = 0.32; 95% CI, 0.15-0.50; I2 = 55.9%). Regarding the type of robot devices, the effects of the end effector device (Hedges g = 0.22; 95% CI, 0.09–0.36; I2 = 35.4%), but not the exoskeleton device, were superior to conventional rehabilitation. Regarding the stroke stage, the between-group difference (ie, RT vs convention rehabilitation) was significant only for people with late subacute or chronic stroke (Hedges g = 0.33; 95% CI, 0.16-0.50; I2 = 34.2%).

Conclusion
RT might be superior to conventional rehabilitation in improving upper extremity motor impairment in people after stroke with notable upper extremity hemiplegia and limited potential for spontaneous recovery.