bluuebunny/crossref_metadata_2025_split huggingface dataset:
State of cardiovascular system in employees with chronic obstructive pulmonary disease in combination with arterial hypertension in terms of exposure to toxic games
Authors: Panacheva L. A. , Shpagina L. A. 
Published: April 2021

Objective. Identification of the features of the cardiovascular system damage in chronic obstructive pulmonary disease (COPD) combined with arterial hypertension (AH) in workers exposed to toxic gases (TG).
Materials and methods. 132 house painters and paint production workers of the Novosibirsk aviation enterprise were included in 3 strata and examined: I-COPD and TG; II-COPD in combination with AH when exposed to TG; III COPD in combination with AH without exposure to TG. Employees of all strata were divided by length of service less than 10 and more than 10 years. The selection of workers in groups was carried out by a continuous method.
Results. The most pronounced changes on the ECG, regardless of the length of service, were observed in workers with COPD in combination with hypertension and contact with TG (levogram and metabolic changes in the myocardium). When exposed to TG for more than 10 years, hypertrophy of the left parts of the heart was also detected. Among workers with COPD in combination with hypertension exposed to TG, the indicators of average pulmonary artery pressure (APAP) and pulmonary vascular resistance (PVR) elevated with increasing work experience; changes in the structure and function of the right and left parts of the heart and signs of remodeling of large vessels were also revealed. The same workers showed more pronounced changes in the daily blood pressure profile (DBPP) of AP with the prevalence of Non-dippers and Night-pickers.
Conclusions. Among workers suffering from comorbid pathology, with increasing duration of TG exposure over 10 years, there were observed the most pronounced ECG changes (deviation of electrical axis to the left, metabolic changes in the myocardium, hypertrophy of the left heart); increased APAP and PVR 1.21 and 1.10 times; changes in the structure and function of the right and left chambers of the heart, remodeling of large vessels; increase in the frequency of variants of the DBPP of Non-dippers and Night-pickers.
Necessary Academic Training Needs at the College of Education, University of Khartoum from the Faculty Members' Perspective
Authors: Elzain Elkhalefa Elkhder  
Published: April 2021

The research aimed at identifying educational and academic training needs required for faculty members in the College of Education at the University of Khartoum from their point of view, as well as to find out any statistically significant differences in the degree of training needs due to two variables (gender and academic degree). The research followed the descriptive analytical approach, and the research population covered all faculty members of the College of Education, University of Khartoum. A simple random sample of (97) members was selected. The questionnaire was used as the main tool for collecting the required data. To analyze the data statistically, the SPSS program was used. Major findings revealed that the degree of educational and academic training needs of faculty members in the College of Education at the University of Khartoum was high, with statistically significant differences attributed to the variable (academic degree). The results also showed that there were no statistically significant differences attributed to the variable (gender). In light of these results, the research concluded with a set of recommendations, including: the university and college administrations should pay attention to various training programs on a continuous basis in both professional and academic fields, priority should be given to the areas of e-learning and statistical analysis, and faculty members should be encouraged to attend training courses.
Keywords: training, educational needs, academic needs
Fungsi Kafe “Omnivora” Sebagai Ruang Sosial Bagi Mahasiswa Di Banjarmasin
Authors: Muhlisah Muhlisah 
Published: April 2021

Kafe merupakan tempat yang sangat digemari anak muda terutama mahasiswa. Kegemaran mahasiswa mengunjungi kafe menjadikannya memiliki berbagai fungsi, salah satunya sebagai ruang sosial. Penelitian ini bertujuan: (1) Untuk menjelaskan aktivitas yang dilakukan mahasiswa ketika berada di kafe Omnivora; (2) Untuk mengetahui bentuk komunikasi yang dilakukan oleh mahasiswa ketika berada di kafe Omnivora. Hasil penelitian ini menggambarkan bahwa: (1) aktivitas yang dilakukan mahasiswa ketika berada di kafe ada berbagai macam seperti: berkumpul bersama teman untuk merayakan ulang tahun, berkumpul dengan teman kuliah, berkumpul dengan teman sepergaulan, bermain kartu Uno dan jenga; mahasiswa makan dan minum di kafe Omnivora sambil berkumpul bersama teman dan lokasi dekat kampus; mahasiswa berfoto di kafe Omnivora untuk menyimpan memori kebersamaan dan memasukkan ke sosial media; mahasiswa mengerjakan tugas di kafe Omnivora bersama teman untuk saling membantu satu sama lain; dan rapat organisasi, karena kafe Omnivora memiliki kursi kayu yang mudah di sesuaikan dan ruangan yang luas; menggunakan fasilitas Wi-Fi untuk mencari bahan kuliah, bermain games online dan mengakses sosial media (2) Komunikasi yang terjadi berupa komunikasi antarpribadi dilakukan oleh mahasiswa menceritakan masalah pribadi yang mengharapkan solusi; komunikasi kelompok untuk saling menghibur, bertukar informasi; dan komunikasi organisasi merupakan komunikasi yang dilakukan mahasiswa untuk merencanakan kegiatan organisasi. Kata Kunci: Fungsi, kafe, ruang sosial.
Rancang Bangun Dan Evaluasi Media Pengenalan Hewan Serangga Dengan Teknologi Augmented Reality
Authors: Purnomo Fendi Aji 
Published: April 2021

<p>Abstrak :</p><p>Usia dini merupakan salah satu masa penting bagi seorang anak dalam mengembangkan bakat dan potensinya. Dalam Pendidikan Anak Usia Dini juga diajari untuk mengenal tentang berbagai macam hewan contohnya serangga. Anak-anak mulai diperkenalkan pembelajaran tentang berbagai macam hewan serangga seperti belalang, kepik, wangwung, lalat, nyamuk dan sebagainya. Guru mengenalkan berbagai macam serangga tersebut dengan menggunakan media buku bergambar. Buku bergambar memiliki keterbatasan, yaitu hanya menampilkan gambar dan teks. Teknologi <em>Augmented Reality </em>dapat dimanfaatkan sebagai media bantu pembelajaran mengenalkan berbagai macam serangga dengan menambahkan objek 3 dimensi di atas media buku tersebut. Metode penelitian mengadopsi metode <em>Multimedia Development Life Cycle</em> (MDLC). MDLC terdiri dari enam tahap yaitu pengonsepan, perancangan, pengumpulan materi, pembuatan, pengujian , dan pendistribusian. Hasil penelitian berupa aplikasi pembelajaran tentang pengenalan aneka macam serangga dalam aplikasi android. Aplikasi AR SERANGGA ini dibuat secara interaktif dengan menggunakan alat bantu <em>marker </em>untuk menampilkan obyek dalam bentuk 3 dimensi dan informasi yang ditampilkan agar anak usia dini tertarik atau antusias dalam kegiatan belajar mengajar yang dibuktikan dengan 70% responden memberikan nilai setuju atas aplikasi ini.</p><p>_____________________________</p><p>Abstract : </p><p><em>Early childhood is one of the important times for a child to develop his talents and potential. In Early Childhood Education, it is also taught to get to know various kinds of animals, for example insects. Children were introduced to learning about various kinds of insects such as grasshoppers, ladybugs, wangwung, flies, mosquitoes and so on. The teacher introduces the various kinds of insects using picture books as media. Picture books have limitations, which only display pictures and text. Augmented Reality technology can be used as a learning aid to introduce various kinds of insects by adding 3-dimensional objects on top of the book media. The research method adopted the Multimedia Development Life Cycle (MDLC) method. The MDLC consists of six stages, namely drafting, designing, gathering materials, manufacturing, testing, and distributing. The results of the research are in the form of a learning application about the introduction of various kinds of insects in an android application. The AR SERANGGA application is made interactively by using marker tools to display objects in 3-dimensional form and the information displayed so that early childhood is interested or enthusiastic in teaching and learning activities as evidenced by 70% of respondents giving agreed scores on this application.</em></p>
Experimental and DFT studies on the structural and optical properties of chitosan/polyvinyle pyrrolidone/ZnS nano composites
Authors: Abdelghany A. M. , Aboelwafa M.A. , Meikhail M.S. , Oraby A 
Published: April 2021

Abstract
Chitosan/ Polyvinyl pyrrolidone (CS/PVP) semi-natural polymeric blend involving gradient concentrations of ZnS nanoparticles (ZnS-NPS) was prepared via a simple casting method. In conjunction with computational density functional theory approaches (DFT), prepared samples were characterized by UV/Vis spectrophotometric studies and Fourier transform infrared measurements (FTIR) to take into account a detailed description of the different reaction mechanisms within the polymeric matrices. To conduct all calculations, the Becke three-parameter hybrid functional (B3LYP) correlation function used with the electron core potential basis set LANL2DZ was used. A detailed study for different reaction regimes was studied and reaction via Oxygen was observed to be preferred and compatible with that of the experimental data. UV/vis. Absorption experimental data were used to calculate the optical energy gap using the Mott-Davis equation and observed data was found to follow an indirect transition route.
Targeting To Hedgehog Signalling Pathway Increase Sensitivity Anticancer Effects of Arsenic Trioxide Mediated By miR-326
Authors: Chen Lei , Ye Qile , Su Yue , Yuan Fei , Yuan Kaikun , Li Qingsong , Zheng Yongri , Wang Dan , Tian Yu 
Published: April 2021

Abstract
Background: The radical cure of Glioblastoma multiforme (GBM) is a troublesome medical problem, owing to its resistance to temozolomide chemotherapy and very poor surgical results or high relapse rate. Resistance to temozolomide emerges from numerous signalling pathways that are altered in GBM, especially the hedgehog signalling pathway. Hence, further research is urgent needed to identify more effective treatment modalities. Methods: We evaluated the effect of ATO on viability, cell proliferation, colony formation production. Flow cytometer assesses the degree of apoptosis, and Western blot analysis the expression of hedgehog signalling pathway proteins(Gli1, Gli2 and SMO). Moreover, use database(CGGA and TCGA) to inquire the relationship between Arrb1 expression level and miR-326 expression level in different levels of gliomas. Finally, The methylation sequencing level of CpG in Arrb1 gene with the survival period of nude mice gives a good explanation to the results of the Immunohistochemica.Results: Flow cytometer showed that the ATO caused apoptosis increased in a dose-dependent manner. Western blot analysis revealed the low expression of Gli1, Gli2 and SMO as well as the mRNA levels(included FOXM1). Arrb1 expression level was positively related with miR-326 expression level in different levels of gliomas from databases(CGGA and TCGA). Immunohistochemical analysis showed that ATO downregulated the expression of SMO, GLI1and Arrb1. The methylation level of CpG in Arrb1 gene was significantly reduced and the survival period of nude mice was prolonged by ATO. Conclusion: Our results showed that the cytotoxicity of ATO could be regulated by the SMO via Hh signalling pathway as well as miR-326, presenting a promising potential therapy for patients with GBM.
Uncovering Configurations of Internal and External Factors for Creating Firm's High Green Innovation Performance Using csQCA
Authors: Cai Youhua , Du Ling , Jiang Xiaozhen 
Published: April 2021

Abstract
Green innovation is a key component of sustainable development amid the fast transition to a low-carbon world. As the most populous country in the world, China displays apparent disparity of green innovation across regions. The extant literature mainly conducted a single factor research on the impact of green innovation and come to conflicting results. Therefore, this study aims to systematically investigate the antecedent multi-factor mechanisms contributing to high green innovation performance.We make the initial attempt to employ a clear-set qualitative comparative analysis(QCA) method to conduct a multi-factor configuration analysis with a sample of 30 provinces and autonomous regions in China. Different from the traditional quantitative regression analysis, this study analyzes 7 conditions jointly to explore the underlying configurations mechanism of green innovation. The results reveal 3 driving configurations for high green innovation performance: resource-driven, policy-dependent and environment-friendly. And the results further suggest that: First, innovation resources ensure the development of green innovation ,and high green innovation performance depends on the richness of innovation resources; Second, environmental regulation serves as a key condition to improve green innovation in the regions with high investment in green innovation and strong government support, and the policy support and effective government guidance are the guarantees for green innovation; Third, the quantity of inter-provincial R&D technology spillovers or foreign investment is the driving force for green innovation in the regions with strong social responsibility. This study takes into consideration of multi-factors that may affect green innovation to address the potential causal relationships, which overcomes the inconsistency in previous single-factor research. The findings shed light on the feasible paths for managers to improve firms’ high green innovation performance in practice.
Dynamic Multivariate Analysis for Pollution Profiling and Abatement Recommendation in La Buong Watershed of Vietnam
Authors: Pham Luan Hong , Tran Dung Duc , Le Hien Dieu Thi , Dinh Toan Quang , Nguyen Quan Hong , Dao Khoi Nguyen , Nguyen Hue Thanh Thi , Nguyen Au Hai 
Published: April 2021

Abstract
Analysis of temporal patterns of high-dimensional time-series water quality data is essential in informing better pollution management. In this study, Dynamic Factor Analysis (DFA) and Cluster Analysis (CA) were adopted to analyze time-series water quality data monitored at five stations SB1, SB2, SB3, SB4 and SB5 on La Buong river in the Southern Vietnam. Application of DFA identified two temporal patterns in SB1 and SB2 and three temporal patterns in SB3, SB4 and SB5. Analysis of factor loadings of water variables revealed run-off-driven patterns with the contribution of Total Suspended Solid (TSS), turbidity or Fe at all stations. The association of other variables like BOD5, COD at SB1, SB2, SB4, and SB5 to this run-off pattern exposed their sharing of common driver. On the contrary, separation of variables like Phosphate (PO43−) in SB3, SB4 and SB5 from run-off pattern suggested their local point-source origin. The derived factors from DFA were later used in time-point CA to explore temporal distribution of pollution intensities. Comparisons between clusters’ value and two regulatory benchmarks A2 and B1 for drinking and irrigation water respectively suggested land-use approach for abating TSS, Fe and BOD5, COD at most sites. The control of point sources of BOD5 and COD pollutants is needed at SB3 along with PO43−, Ammonium (NH4+) and Escherichia coli (E.coli) at SB1 and SB4.
Association of Efflux Pump and OMPs with Antibiotic Susceptibility Among ESBL-Producing Klebsiella Pneumoniae Clinical Strains in Malaysia
Authors: Mobasseri Golnaz , Lin Thong Kwai , Teh Cindy Shuan Ju 
Published: April 2021

Abstract
Multidrug-resistant (MDR) Klebsiella pneumoniae (K. pneumoniae) poses a serious public health threat. K. pneumoniae strains that produce extended-spectrum beta-lactamases (ESBL) are becoming increasingly reported in nosocomial and community-acquired infections. Besides resistance genes, integrons, and plasmids, altered membrane permeability caused by porin loss and energy-dependent efflux have also contributed to antibiotic resistance in K. pneumoniae. The objective of this study was to determine the correlation between the reduction of antibiotic susceptibility and overexpression of efflux pump as well as the lack of outer membrane proteins (OMPs) among clinical ESBLs resistant K. pneumoniae. The expression levels of ramA, acrA, ompK35 and ompK36 in 12 MDR K. pneumoniae strains with varying MICs levels were analyzed using quantitative real time-Polymerase Chain Reaction (qRT-PCR). The role of efflux pump on antibiotic resistance was also studied by using minimum inhibitory concentration (MICs) method with//without efflux pump inhibitor. The result indicated that the strains with highest resistance to cefotaxime showed the lowest level of ompK35 and ompK36 genes expression while the strains with lowest MIC level of resistance to cefotaxime showed the highest level of expression of acrA and ramA. Our finding also revealed the effect of efflux pump inhibitor phenyl-arginine-b-naphthylamide (PAβN) on the MIC levels of ceftazidime, amoxicillin-clavulanate and cefotaxime which were significantly reduced around 1–7 folds MIC levels. These results suggest that Efflux pump system and deficiently of OMPs contributing role in antibiotic susceptibility which should be taken seriously to prevent the treatment failure due to antimicrobial resistance.
The Association Between Healthcare Resources, Non-communicable Diseases, and Covid-19 Mortality: An Epidemiological Study of 139 Countries
Authors: Arsang-Jang Shahram , Belasi Masoud Tokazebani , Najafi Farid , Darbandi Mitra , Raza Malik Zain , Akhuanzada Humayon , Yassi Nawaf , Biller Jose , Zand Ramin , Neya Sepideh Kazemi , Morovatdar Negar , Stranges Saverio , Napoli Mario Di. , Azarpazhooh M. Reza 
Published: April 2021

Abstract
Background: To provide an overview of the worldwide association between hospital beds, the burden of non-communicable diseases (NCDs), and COVID-19 mortality.Methods: Data was extracted regarding COVID-19 deaths and cases from the Our World in Data as of March 23, 2021. The following data was obtained:1) NCDs disability-adjusted life years (DALYs), health-adjusted life expectancy, and the health access and quality index from the Global Burden of Disease study; 2) the number of hospital beds, physicians, nurses and midwives per population, and out-of-pocket payments from the WHO website. Using the multilevel generalized linear model, these variables’ independent associations with COVID-19 mortality rate ratio (MRR) was examined.Results: Hospital beds were associated with reduced COVID-19 mortality (MRR=0.47; 95% CI: 0.44 to 0.5) globally. During COVID-19 peak periods, despite a decreasing trend in COVID-19 MRR with increasing beds in high-income countries, the odds of mortality remained high even within the highest percentile of hospital beds (MRR=1.54 for 20th-40th and 1.06 for >60th bed percentile, respectively). On the contrary, in middle-income countries, an inverse association was observed between the number of hospital beds and COVID-19 mortality in both periods. NCD DALYs were associated with increased COVID-19 deaths, particularly during peak mortality periods in high-income countries. Death-to-case ratio increased by approximately two times during the peak vs non-peak mortality periods.Conclusions: COVID-19 is a syndemic interacting with non-communicable diseases and not only a pandemic. A comprehensive national healthcare plan against COVID-19 spread should include adequate measures to protect vulnerable patients with pre-existing chronic conditions.
A Mechanically Reprogrammable Pancharatnam-Berry Metasurface
Authors: Xu Quan , Su Xiaoqiang , Zhang Xueqian , Dong Lijuan , Liu Lifeng , He Jiajun , Wen Lohong , Liu Yuzhu , Huang Yucong , Shi Yunlong , Wang Qiu , Kang Ming , Alu Andrea , Zhang Shuang , Han Jiaguang , Zhang Weili 
Published: April 2021

Abstract
Metasurfaces have enabled the realization of several optical functionalities over an ultrathin platform, fostering the exciting field of flat optics. Traditional metasurfaces are achieved by arranging a layout of static meta-atoms to imprint a desired operation to the impinging wavefront, but their functionality cannot be altered. Reconfigurability and programmability of metasurfaces are the next important step to broaden their impact, adding customized on-demand functionality in which each meta-atom can be individually reprogrammed. However, programmable metasurfaces to date can only reconfigure 2 or 4 phase levels per meta-atom at best, hindering the overall functionality performance. Here, we demonstrate a mechanical metasurface platform with controllable rotation at the meta-atom level, which can implement continuous Pancharatnam-Berry phase control of circularly polarized waves. As the proof-of-concept experiments, we demonstrate metalensing, focused vortex beam generation, and holographic imaging in the same metasurface template, exhibiting versatility and superior performance. Such dynamic control of electromagnetic waves using a single, low-cost metasurface paves an avenue towards practical applications, driving the field of reprogrammable intelligent metasurfaces for a variety of applications.
A Novel User Grouping Algorithm for Downlink NOMA
Authors: Jeshvaghani Navideh Ghafouri , Movahhedinia Naser , Khayyambashi Mohammad Reza 
Published: April 2021

Abstract
Non-orthogonal multiple access (NOMA) is one of the promising radio access techniques for resource allocation improvement in the 5th generation of cellular networks. Compared to orthogonal multiple access techniques (OMA), NOMA offers extra benefits, including greater spectrum efficiency which is provided through multiplexing users in the transmission power domain while using the same spectrum resources non-orthogonally. Even though NOMA uses Successive Interference Cancellation (SIC) to repeal the interference among users, user grouping has shown to have a substantial impact on its performance. This prformance improvement can appear in different parameters such as system capacity, rate, or the power consumption. In this paper, we propose a novel user grouping scheme for sum-rate maximization which increases the sum-rate up to 25 percent in comparison with two authenticated recent works. In addition to being matrix-based and having a polynomial time complexity, the proposed method is also able to cope with users experiencing different channel gains and powers in different sub-bands.