bluuebunny/crossref_metadata_2025_split huggingface dataset:
Levels of methylated arginines and L-arginine in patients with polycystic ovary syndrome: a promising approach in clinical evaluation
Authors: OZTAN Ozgur , ERDOĞAN Gökçen , ŞİMŞİR Coşkun , TÜRKSOY Vugar Ali , ABUŞOĞLU Gülsüm , TUTKUN Lütfiye , DENİZ Serdar , ALAGÜNEY Mehmet Erdem 
Published: November 2021

Aim: Polycystic ovary syndrome (PCOS) is a prevalent disease in women. PCOS is related with metabolic syndrome and associated with cardiovascular disorders. Methylated arginine is involved in endothelial dysfunction, inflammation and atherosclerosis pathophysiology. Our aim is to determine the association between PCOS and methylated arginine metabolites in order to investigate the role of vascular factors in the etiopathogenesis of PCOS.
Material and Method: This is a case-control study. The study group is consisted of 45 PCOS cases and 45 controls. The case group is patients who applied to Department of Gynecology and diagnosed with PCOS. Control group is consisted of healthy volunteers who applied to the outpatient clinics for other reasons. The study took place in Department of Gynecology in XX hospital. Data collection was held between 2018 October to 2019 June. Methylated arginine derivatives such as ADMA, SDMA, L-NMMA (L-NG-monomethyl Arginine Acetate) and also arginine and citrulline were determined.
Results: ADMA, SDMA, L-NMMA, arginine, citrulline, Arginine/ADMA, SDMA/ADMA and total methylarginine parameters showed statistically significant differences between groups. Strong positive relation was determined between scoring of Ferriman-Gallway (FGS) and luteinizing hormone (LH), glucose, insulin, ADMA, citrulline, homoarginine, L-NMMA and total methylarginine levels.
Conclusions: High levels of methylated arginine/NO pathway metabolites in PCOS patients may be related with cardiovascular outcomes of PCOS.
Combined effects of the implementation of magnesium and ascorbic acid on myocardial ischemia-reperfusion in open heart surgery
Authors: GÜLTEKİN Yıldırım , GÜZEL Abdulkadir , KARAKAYA Atalay , BEŞOĞUL Yavuz 
Published: November 2021

Aim: This study aimed to investigate the combined effects of magnesium (Mg) and high dose ascorbic acid on cardiac ischemia-reperfusion (IR) injury.
Material and Method: This study was performed on 45 patients that were scheduled for coronary artery bypass graft (CABG) operations. The patients were divided into three equal groups. Group C received 50 mg/kg ascorbic acid; Group CM received the same dose of ascorbic acid plus 30 mg/kg Mg; Group K received neither ascorbic acid nor Mg. At various times during the operation, the blood levels of malondialdehyde (MDA), serum creatine kinase MB (CK-MB), and lactate dehydrogenase (LDH) levels were analyzed.
Results: There were statistically significant decreases in arrhythmia requiring intervention in Group CM compared to Group K (P=0.026). MDA levels increased in all groups but MDA 2 and MDA 3 levels were found to be statistically significantly lower in Group C and Group CM than in Group K (P=0.009, P=0.012, P=0.009 and P=0.006 respectively). However, inhibition of lipid peroxidation in both Group C and Group CM was not parallel to cardiac enzymes and hemodynamic measurements. There was no significant statistical difference in the cardiac enzyme levels between Group K, Group C, and Group CM (p>0.05).
Conclusion: To reduce the IR, Mg with a high dose of ascorbic acid may be efficacious in patients undergoing cardiac surgery. A larger population group is needed to prove the results of this study.
Active Galactic Nuclei Abundance in Cosmic Voids
Authors: Mishra Hora D. , Dai Xinyu , Guerras Eduardo 
Published: November 2021

Abstract
The abundance of active galactic nuclei (AGN) in cosmic voids is relatively unexplored in the literature, but can potentially provide new constraints on the environmental dependence of AGN activity and the AGN-host coevolution. We investigated AGN fractions in one of the largest samples of optically selected cosmic voids from Sloan Digital Sky Survey Data Release 12 for redshift range 0.2–0.7 for moderately bright and bright AGN. We separated inner and outer void regions based on the void size, given by its effective void radius. We classified galaxies at a distance <0.6 R
eff as inner void members and galaxies in the interval 0.6 < R/R
eff < 1.3 as outer void galaxies. We found higher average fractions in the inner voids (4.9 ± 0.7)% than for their outer counterparts (3.1 ± 0.1)% at z > 0.42, which clearly indicates an environmental dependence. This conclusion was confirmed upon further separating the data in narrower void-centric distance bins and measured a significant decrease in AGN activity from inner to outer voids for z > 0.42. At low redshifts (z < 0.42), we find very weak dependence on the environment for the inner and outer regions for two out of three bins. We argue that the higher fraction in low-density regions close to void centers relative to their outer counterparts observed in the two higher-redshift bins suggests that more efficient galaxy interactions may occur at a one-to-one level in voids that may be suppressed in denser environments due to higher velocity dispersions. It could also indicate less prominent ram pressure stripping in voids or some intrinsic host or void environment properties.
Possible effect of alkalization therapy on SARS-CoV-2 virus lifecycle
Authors: Elsadani Khaled 
Published: November 2021

This proposal tries to drive attention to the observation that pH variation plays a fundamental role in the functional mechanism of SARS-CoV-2 virus proteases. Depending on this role, testing the effect of alkalization therapy on the SARS-CoV-2 patients could be reasonable.
La rue bordée de boutiques au-dessus de l’Odéon de Lyon (Haut-Empire)
Authors: Fellague Djamila , Houal Jean-Baptiste , Olivero Davide , Papadopoulou Anna , Mignon Jean-Marc 
Published: November 2021

L’article est consacré à la rue bordée de boutiques-ateliers visible au-dessus de l’odéon de Lyon. Un bilan historiographique est suivi d’une mise au point sur les caractéristiques des vestiges et sur leur chronologie, qui ne peut être fondée sur aucune stratigraphie. Cette présentation est l’occasion de s’arrêter sur une fontaine de rue ainsi que sur une construction inédite, de nature indéterminée, située devant un mur peint à pilastres. La chronologie avancée pour la fontaine a une incidence sur la restitution de la circulation des véhicules à l’échelle de la ville : elle affaiblit l’hypothèse de la condamnation de la rue carrossable après la construction de l’édifice de spectacle. Au contraire, c’est peut-être la volonté de la maintenir en usage qui a pu engendrer la suppression du lacus et des boutiques afin de réaliser, à peu de frais, un décalage de la rue et du portique.
Travail reproductif et parentalité
Authors: Gabaret Jim 
Published: November 2021

Les théories féministes ont souvent critiqué l’essentialisme intrinsèque aux notions de « nature », de « naturel féminin ou masculin » et de « droit naturel ». Mais la notion de nature ne peut pas être si vite disqualifiée. Les luttes de reconnaissance du travail domestique, émotionnel et reproductif mobilisent ainsi implicitement un droit naturel du travail. Elles usent pour ce faire d’un concept de « travail » dont on critiquera l’application aux tâches d’enfantement ou de soin. Mais d’après certaines théories du care dont on étudiera les liens avec les sciences naturelles, c’est en admettant que ces tâches ne sont pas du travail, mais justement des activités « naturelles », d’une « nature » humaine qui concerne autant le masculin que le féminin, qu’on pourra participer à mieux les répartir.
La semaine sanglante : une formule ?
Authors: Dontenwille-Gerbaud Aude 
Published: November 2021

L’épisode tragique de la fin mai 1871 où les troupes républicaines versaillaises entrent dans Paris insurgé pour mettre fin à l’expérience de la Commune se nomme classiquement semaine sanglante . Cet article interroge le choix graphique d’emploi de majuscules, de minuscules et de guillemets dans l’écriture du syntagme. Dans une démarche en analyse du discours, l’historienne travaille un corpus hétérogène constitué de textes littéraires, d’ouvrages politiques, d’articles de presse ou encore d’analyses historiographiques couvrant la large période de mai 1871 à nos jours. Cette recherche exploratoire ne prétend en rien à l’exhaustivité et demande à être poursuivie, notamment par la constitution d’un corpus en langue anglaise.
Gα13 Mediates Transendothelial Migration of Neutrophils by Promoting Integrin-Dependent Motility without Affecting Directionality
Authors: Chang Claire W , Cheng Ni , Bai Yanyan , Skidgel Randal A , Du Xiaoping 
Published: November 2021

Abstract
Neutrophil migration requires β2 integrins and chemoattractant receptor signaling for motility and directionality. G protein subunit Gα13 can facilitate cell migration by mediating RhoA activation induced by G protein–coupled receptors. However, the possible role of Gα13-integrin interaction in migration is unclear. In this study, we show that Gα13−/− neutrophils are deficient in transendothelial migration and migration on β2 integrin ligand ICAM-1. However, unlike G protein–coupled receptors and integrin inside-out signaling pathways, Gα13 is important in migration velocity and neutrophil spreading but not in directionality nor cell adhesion. Importantly, neutrophil recruitment in vivo was also inhibited in Gα13−/− mice, suggesting the importance of Gα13 in transendothelial migration of neutrophils in vitro and in vivo. Furthermore, a synthetic peptide (MB2mP6) derived from the Gα13 binding site of β2 inhibited Gα13-β2 interaction and Gα13-mediated transient RhoA inhibition in neutrophils, suggesting that this peptide inhibited integrin outside-in signaling. MB2mP6 inhibited migration of control neutrophils through endothelial cell monolayers or ICAM-1–coated filters, but was without further effect on Gα13−/− neutrophils. It also inhibited integrin-dependent neutrophil migration velocity without affecting directionality. In vivo, MB2mP6 markedly inhibited neutrophil infiltration into the cardiac tissues induced by ischemia/reperfusion injury. Thus, Gα13-dependent outside-in signaling enables integrin-dependent neutrophil motility without affecting directionality and may be a new therapeutic target for inhibiting neutrophil trafficking but not adhesion.
FAM177A1 Inhibits IL-1β–Induced Signaling by Impairing TRAF6–Ubc13 Association
Authors: Liao Bo-Wei , Zhang Hong-Yan , Du Wen-Tian , Ran Yong , Wang Yan-Yi , Xu Zhi-Sheng 
Published: November 2021

Abstract
The proinflammatory cytokine IL-1β is a crucial mediator of inflammatory responses. IL-1β–induced signaling is finely regulated by various mechanisms, and its imbalance is involved in a variety of diseases. In this study, we identified FAM177A1, a protein of unknown function, as a negative regulator of IL-1β–induced signaling in human cells. Overexpression of FAM177A1 inhibited IL-1β–triggered activation of NF-κB and transcription of inflammatory genes, whereas knockdown of FAM177A1 showed the opposite effects. Mechanistically, FAM177A1 competitively bound to the E3 ubiquitin ligase TRAF6 and impaired its interaction with the E2-conjugating enzyme Ubc13; therefore, it inhibited TRAF6-mediated polyubiquitination and recruitment of downstream signaling molecules. These findings reveal a function of FAM177A1 and promote our understanding of the regulatory mechanisms of IL-1β–induced inflammatory responses.
The Calcium Channel Inhibitor Nimodipine Shapes the Uveitogenic T Cells and Protects Mice from Experimental Autoimmune Uveitis through the p38–MAPK Signaling Pathway
Authors: Hu Yunwei , Chen Guanyu , Huang Jun , Li Zhuang , Li Zuoyi , Xie Yanyan , Chen Yuxi , Li He , Su Wenru , Chen Xiaoqing , Liang Dan 
Published: November 2021

Abstract
Autoimmune uveitis (AU) is a sight-threatening ocular inflammatory disorder, characterized by massive retinal vascular leakage and inflamed lesions with infiltration of the uveitogenic T cells in the retina and disorders of the T cell–related immune response in the system. Stimulation of TCRs can trigger calcium release and influx via Ca2+ channels and then transmit signals from the surface to the nucleus, which are important for energy metabolism, proliferation, activation, and differentiation. Inhibition of Ca2+ influx by pharmacological modulation of Ca2+ channels may suppress T cell function, representing a novel anti-inflammatory strategy in the treatment of AU. This study investigated the effects of the l-type voltage-gated calcium channel blocker nimodipine in experimental AU (EAU). Nimodipine was found to not only decrease the clinical and histopathological inflammation score of EAU (C57BL/6J mice) but also dwindle the infiltration of uveitogenic CD4+ T cells into the retina. Moreover, nimodipine decreased the effector T cells and increased the regulatory T cells in the immune system. In vitro, nimodipine reduced the effector T cell differentiation of the IRBP1–20–specific CD4+ T cells of EAU mice and LPS-stimulated PBMCs of uveitis patients. Meanwhile, nimodipine suppressed the energy metabolism, proliferation, activation, and Th1 cell differentiation of T cells. Further studies on RNA sequencing and molecular mechanisms have established that nimodipine alleviates EAU by regulating T cells response through the p38–MAPK pathway signaling. Taken together, our data reveal a novel therapeutic potential of the l-type Ca2+ channels antagonist nimodipine in AU by regulating the balance of T cell subsets.
Evaluation of antenatal services at Family welfare Centre under RMNCH+A Programme in Delhi
Authors: Kaur Gurmeet , Gupta Kalika , Shyam Subhajit 
Published: November 2021

Background:
According to WHO, 536,000 women die every year in the world from causes relating to pregnancy, childbirth, or postpartum. Ninety nine percent of these deaths occur in the developing countries. Primary health centres (in densely populated areas and in urban slums are also referred to as family welfare centres, since they provide the whole continuum of care, from birth through adolescent and delivery and thereafter.

Aim:
To evaluate the antenatal services under Reproductive, Maternal, Newborn, Child plus Adolescent (RMNCHA) programme at a family welfare centre located in Central Delhi, India. We have proposed an action plan that will help in evaluating and improving these services.

Methodology:
The study included health providers of antenatal services and the beneficiaries. With a response rate of 90% from a sample of 218, 203 consenting antenatal women (beneficiaries) visiting the centre for ANC check-up under RMNCH + A programme and PMSMA were included. For quantitative component, a pre-designed, pre-tested semi-structured screening questionnaire were administered to the beneficiaries and healthcare providers to evaluate the antenatal services under RMNCH + A programme at the family welfare centre.

Results:
Qualitative and quantitative analysis was done separately. Only 43% of ANC women said health workers visited them at home during pregnancy and very few could tell about importance of lab investigations. Almost all (97%) knew about key messages given by health workers. Nearly all participants considered that the screening process was smooth. The waiting time and time to undergo varied from 4 to 6 min.
Psychological self-security and self-concept among Saudi epilepsy patients at a tertiary care center in KSA
Authors: Aldosary Wardah S. , Heena Humariya , El-Bakri Nahid. K. 
Published: November 2021

Objective:
While psychological issues in epilepsy patients have been studied extensively, the phenomena of self-concept and self-security have not been adequately addressed in such patients. Therefore, the aim of the current study is to assess the levels of psychological self-security and self-concept among Saudi epilepsy patients.

Methods:
A case-control study was conducted on adult patients with epilepsy from the Epilepsy Monitoring Unit at King Fahad Medical City in Riyadh, Saudi Arabia. Healthy controls were obtained from the community. Demographic data including age, gender and education level were collected. Self-concept and self-security were assessed using validated scales. Descriptive statistics were obtained, and inferential testing was conducted.

Results:
Data from 145 subjects was entered in the final analysis, including 100 patients with epilepsy and 45 controls (females = 32%). A significantly higher level of psychological insecurity was found in PWE (people with epilepsy) compared to controls. No significant difference was noticed on self-concept level between PWE versus controls. Education level was significantly lower in PWE than in controls. Those with higher education levels scored lower on psychological insecurity, although this effect disappeared when the data were split by health status.

Conclusion:
Level of psychological self-security was higher in PWE than controls, while no difference in self-concept was observed. This study highlights the areas of focus needed in epilepsy-related social services in order to improve the psychological wellbeing of patients with epilepsy.
Are the labour rooms of primary healthcare facilities capable of providing basic delivery and newborn services? A cross-sectional study
Authors: Sachan Divyata , Kumar Deepak , Gangwar Abhinav , Jain Pankaj Kumar , Kumar Sandip , Shukla Sushil Kumar , Srivastava Dhiraj Kumar , Kharya Pradip , Bajpai Prashant Kumar , Pathak Pooja , Rao Tamma Raja 
Published: November 2021

Objectives:
The study aimed to assess the functionality of labour rooms by evaluating the labour room infrastructure with reference to the standard guidelines, the status of the availability of human resources, the availability of essential equipment and consumables in the labour room and by documenting the knowledge of the healthcare provider in terms of labour room practices. The study also explored the facility parameters associated with its delivery load taking the facility as a unit of analysis.

Design:
A cross-sectional analytical study.

Setting:
India has realised the importance of improving the quality of care in public health facilities, and steps are being taken to make healthcare more responsive to women’s needs. With an increase in the proportion of institutional deliveries in India, the outcome of the delivery process can be improved by optimising the health facility components.

Participants:
The study was conducted in 52 health facilities and healthcare providers involved in the delivery process in the selected facilities.

Results:
The infrastructure of the facilities was found to be the best for medical college followed by district hospitals, Community Health Centres (CHCs), Primary Health Centres (PHCs) and subcentres. Similar findings were observed in terms of the availability of equipment and consumables. Lack of healthcare providers was observed as only 20% of the posts for health personnel were fulfilled in CHCs followed by PHCs, subcentres and district hospitals where 43, 50 and 79% of the available vacancies were fulfilled. The level of knowledge of healthcare providers in terms of partograph, active management of the third stage of labour and post-partum haemorrhage ranged as per their designation. The specialists were the most knowledgeable while the Auxiliary Nurse Midwife (AMNs) were the least. All the components of structural capacity, i.e. infrastructure (r
2 = 0.377, P value < 0.001), equipment and consumable (r
2 = 0.606, P value < 0.001) and knowledge of healthcare providers (r
2 = 0.456, P value < 0.001) along with the overall facility score were positively correlated with the average delivery load of the health facility. The results from multivariate linear regression depict significant relation between the delivery load and availability of equipment and consumables (t = 4.015, P < 0.01) and with the knowledge of healthcare providers (t = 2.129, P = 0.039).

Conclusions:
The higher facilities were better equipped to provide delivery and newborn care. A higher delivery load was found at high-level facilities which can be attributed to better infrastructure, adequate supply of equipment and consumables and availability of trained human resources.
Awareness and perception of COVID-19 among final-year dental students, Sudan
Authors: Mahmoud Mai O. , Ali Marwa M. Elameen. I. , Khalifa Amar F. M. 
Published: November 2021

Background:
Infection with COVID-19 has serious consequences, which may lead to severe pneumonia and even death. There is a high risk of infection between dental personnel and patients due to working in proximity while performing dental treatments.

Objective:
This study aims to assess the awareness about COVID-19 and its preventive measures among final-year dental students.

Methods:
Institutional-based cross-sectional study, among the final-year Bachelor of Dental Surgery students, the sample size was 288 participants during the period from August 8, 2020, to August 15, 2020. The data were collected using a self-administered questionnaire formed of a series of close-ended questions about sociodemographic characteristics, knowledge about COVID-19, prevention in dental clinic, and perception toward COVID-19. Data were analyzed using the Statistical Package for Social Science, version 25 (SPSS 20.0, Chicago, IL). The Chi-square test was used for the significance level, which was set at a value of P = 0.05 or less for all analyses.

Results:
Form 288 students, the average age (measured in years) was 23.31 ± 1.8. (means ± SD). A total of 224 (77.8%) respondents were females. For COVID-19-related knowledge, 282 (97.9%) students possessed a high knowledge level, 4 (1.4%) had moderate knowledge, and only 2 (0.7%) showed poor knowledge. Also, 95% of participants responded correctly with a total agreement to questions regarding infection control measurements, the least agreement response (85%) was for: avoid aerosol-generating procedures whenever possible. There are statistically significant relations between knowledge score and gender (P = 0.024), knowledge score and source of knowledge (P = 0.017), and perceived severity and knowledge score (P = 0.001).

Conclusion:
This study illustrated that the knowledge score among participants is good. There are associations between gender and level of knowledge, knowledge score and source of knowledge, and perceived severity and knowledge score.
Practices followed by type-II diabetes mellitus patients for prevention of foot ulcers
Authors: Kaur Vaneet , Kalyani C. Vasantha , Rohilla Kusum K. 
Published: November 2021

Background:
Type-II diabetes mellitus is a serious lifestyle-related health problem globally and its prevalence is rapidly increasing day by day. The main purpose of this study was to assess practices followed by Type-II diabetes mellitus patients regarding the prevention of foot ulcers.

Method:
This study was a cross-sectional study using a case series type of research design. Purposively, a total of 100 type-II diabetes mellitus patients were registered with AIIMS Rishikesh for their treatment. Data collection tools were a semi-structured questionnaire that included 20 items. By conducting an interview schedule, data was collected from each participant.

Results:
Majority of participants belong to age group of 51–60 years and were males. Practice score showed majority of Type-II DM patients were following moderate-level practices, followed by only few (15%) were following good practice for preventing foot ulcers.

Conclusion:
Health care professionals must empathize on educating type-II diabetes patients regarding preventive measures for foot ulcers. Educate patients regarding the importance of self-foot care practice and promoting them for proper follow-up as well to decrease incidence of diabetic foot ulcers.