bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implications of using the GLI-2012, GOLD and Australian COPD-X recommendations in assessing the severity of airflow limitation on spirometry among an Indigenous population with COPD: an Indigenous Australians perspective study
Authors: Heraganahally Subash S , Howarth Timothy P , White Elisha , Ben Saad Helmi 
Published: December 2021

BackgroundAssessment of airflow limitation (AFL) is crucial in the clinical evaluation of patients with chronic obstructive pulmonary disease (COPD). However, in the absence of normative reference values among adult Australian Indigenous population, the implications of utilising the Global Lung Function Initiative (GLI-2012), Global Initiative for Chronic Obstructive Lung Disease (GOLD) and the Australian concise COPD-X recommended severity classifications is not known. Moreover, spirometry values (forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1)) are observed to be 20%–30% lower in an apparently healthy Indigenous population in comparison to Caucasian counterparts.MethodsAdult Indigenous patients diagnosed to have COPD on spirometry (postbronchodilator (BD) FEV1/FVC <0.7 ((GOLD, (COPD-X)) and ≤lower limit of normal (others/mixed reference equations) for GLI-2012) were assessed for AFL severity classifications on Post-BD FEV1values (mild, moderate, severe, very severe) as per the recommended classifications.ResultsFrom a total of 742 unique patient records of Indigenous Australians, 253 were identified to have COPD via GOLD/COPD-X criteria (n=238) or GLI-2012 criteria (n=238) with significant agreeance between criteria (96%, κ=0.901). Of these, the majority were classified as having moderate or severe/very-severe AFL with significant variability across classification criteria (COPD-X (40%–43%), GOLD (33%–65%), GLI-2012 (18%–75%)). The FVC and FEV1values also varied significantly between classification criterion (COPD-X/GOLD/GLI-2012) within the same AFL category, with COPD-X ‘moderate’ AFL almost matching ‘severe’ AFL categorisation by GOLD or GLI-2012.ConclusionsHealth professionals caring for Indigenous patients with COPD should be aware of the clinical implications and consequences of utilising various recommended AFL classifications in the absence of validated spirometry reference norms among adult Indigenous patients.
Primary care providers should prescribe aspirin to prevent cardiovascular disease based on benefit−risk ratio, not age
Authors: Kim Kyungmann , Hennekens Charles H , Martinez Lisa , Gaziano J Michael , Pfeffer Marc A , Biglione Bianca , Gitin Alexander , McCabe Jeanne Bell , Cook Thomas D , DeMets David L , Wood Sarah K 
Published: December 2021

Recent guidelines restricted aspirin (ASA) in primary prevention of cardiovascular disease (CVD) to patients <70 years old and more recent guidance to <60.In the most comprehensive prior meta-analysis, the Antithrombotic Trialists Collaboration reported a significant 12% reduction in CVD with similar benefit−risk ratios at older ages. Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, four trials were added to an updated meta-analysis.ASA produced a statistically significant 13% reduction in CVD with 95% confidence limits (0.83 to 0.92) with similar benefits at older ages in each of the trials.Primary care providers should make individual decisions whether to prescribe ASA based on benefit−risk ratio, not simply age. When the absolute risk of CVD is >10%, benefits of ASA will generally outweigh risks of significant bleeding. ASA should be considered only after implementation of therapeutic lifestyle changes and other drugs of proven benefit such as statins, which are, at the very least, additive to ASA. Our perspective is that individual clinical judgements by primary care providers about prescription of ASA in primary prevention of CVD should be based on our evidence-based solution of weighing all the absolute benefits and risks rather than age. This strategy would do far more good for far more patients as well as far more good than harm in both developed and developing countries. This new and novel strategy for primary care providers to consider in prescribing ASA in primary prevention of CVD is the same as the general approach suggested by Professor Geoffrey Rose decades ago.
Cardiovascular safety profile of taxanes and vinca alkaloids: 30 years FDA registry experience
Authors: Batra Akshee , Patel Brijesh , Addison Daniel , Baldassarre Lauren A , Desai Nihar , Weintraub Neal , Deswal Anita , Hussain Zeeshan , Brown Sherry-Ann , Ganatra Sarju , Agarwala Vivek , Parikh Purvish M , Fradley Michael , Ghosh Arjun , Guha Avirup 
Published: December 2021

ObjectiveAntimicrotubular agents are among the most commonly used classes of chemotherapeutic agents, but the risk of cardiovascular adverse events (CVAEs) remains unclear. Our objective was to study the CVAEs associated with antimicrotubular agents.MethodsThe Food and Drug Administration’s Adverse Event Reporting System was used to study CVAEs in adults from 1990 to 2020. Reported single-agent (only taxane or vinca alkaloid) CVAEs were compared with combination therapy (with at least one of the four major cardiotoxic drugs: anthracycline, HER2Neu inhibitors, tyrosine kinase inhibitors and checkpoint inhibitors) using adjusted polytomous logistic regression.ResultsOver 30 years, 134 398 adverse events were reported, of which 18 426 (13.4%) were CVAEs, with 74.1% due to taxanes and 25.9% due to vinca alkaloids. In 30 years, there has been a reduction in the proportion of reported CVAEs for taxanes from 15% to 11.8% (Cochran-Armitage P-trends <0.001) with no significant change in the proportion of reported CVAEs for vinca alkaloids (9.2%–11.7%; P-trends=0.06). The proportion of reported CVAEs was lower in both taxane and vinca alkaloid monotherapy versus combination therapy (reporting OR=0.50 and 0.55, respectively). Anthracyclines and HER2Neu inhibitor combinations with taxanes or vinca alkaloids primarily drove the higher burden of combination CVAEs. Hypertension requiring hospitalisation and heart failure was significantly lower in monotherapy versus combination antimicrotubular agent therapy.ConclusionsAntimicrotubular agents are associated with CVAEs, especially in combination chemotherapy regimens. Based on this study, we suggest routine cardiovascular assessment of patients with cancer before initiating antimicrotubular agents in combination therapy.
CJT effective potential approach to analyze the nature of phase transition of thermal QED$$_3$$ at finite volume
Authors: Hu Yi , Feng Hong-tao 
Published: December 2021

AbstractBased on the Cornwall–Jackiw–Tomboulis effective potential and the truncated Dyson–Schwinger equations, the nature of phase transition of thermal QED$$_3$$

3

at finite volume is investigated. We show that, with the rise of temperature, the system undergoes a second-order transition in the chiral limit, and remains exhibiting the second-order with small fermion mass, while it switches to a crossover when the fermion mass exceeds a critical value about $$m_{c}$$

m
c

, which diminishes with the increasing volume size and tends to zero in infinite volume.
Exome Sequencing Highlights a Potential Role for Concealed Cardiomyopathies in Youthful Sudden Cardiac Death
Authors: Neves Raquel , Tester David J. , Simpson Michael A. , Behr Elijah R. , Ackerman Michael J. , Giudicessi John R. 
Published: December 2021

Background:
Sudden cardiac arrest (SCA) and sudden unexplained death (SUD) are feared sequelae of many genetic heart diseases. In rare circumstances, pathogenic variants in cardiomyopathy-susceptibility genes may result in electrical instability leading to SCA/SUD before any structural manifestations of underlying cardiomyopathy are evident.

Methods:
Collectively, 38 unexplained SCA survivors (21 males; mean age at SCA 26.4±13.1 years), 68 autopsy-inconclusive SUD cases (46 males; mean age at death 20.4±9.0 years) without disease-causative variants in the channelopathy genes, and 973 ostensibly healthy controls were included. Following exome sequencing, ultrarare (minor allele frequency ≤0.00005 in any ethnic group within Genome Aggregation Database [gnomAD, N=141 456 individuals]) nonsynonymous variants identified in 24 Clinical Genome Resource adjudicated definitive/strong evidence cardiomyopathy-susceptibility genes were analyzed. Eligible variants were adjudicated as pathogenic, likely pathogenic, or variant of uncertain significance in accordance with current American College of Medical Genetics and Genomics guidelines.

Results:

Overall, 7 out of 38 (18.4%) SCA survivors and 14 out of 68 (20.5%) autopsy-inconclusive, channelopathic-negative SUD cases had at least one pathogenic/likely pathogenic or a variant of uncertain significance nonsynonymous variant within a strong evidence, cardiomyopathy-susceptibility gene. Following American College of Medical Genetics and Genomics criterion variant adjudication, a pathogenic or likely pathogenic variant was identified in 3 out of 38 (7.9%;
P
=0.05) SCA survivors and 8 out of 68 (11.8%;
P
=0.0002) autopsy-inconclusive SUD cases compared to 20 out of 973 (2.1%) European controls. Interestingly, the yield of pathogenic/likely pathogenic variants was significantly greater in autopsy-inconclusive SUD cases with documented interstitial fibrosis (4/11, 36%) compared with only 4 out of 57 (7%,
P
<0.02) SUD cases without ventricular fibrosis.

Conclusions:
Our data further supports the inclusion of strong evidence cardiomyopathy-susceptibility genes on the genetic testing panels used to evaluate unexplained SCA survivors and autopsy-inconclusive/negative SUD decedents. However, to avoid diagnostic miscues, the careful interpretation of genetic test results in patients without overt phenotypes is vital.
Provocation Testing and Therapeutic Response in a Newly Described Channelopathy: RyR2 Calcium Release Deficiency Syndrome
Authors: Ormerod Julian O.M. , Ormondroyd Elizabeth , Li Yanhui , Taylor John , Wei Jinhong , Guo Wenting , Wang Ruiwu , Sarton Caroline N.S. , McGuire Karen , Dreau Helene M.P. , Taylor Jenny C. , Ginks Matthew R. , Rajappan Kim , Chen S.R. Wayne , Watkins Hugh 
Published: December 2021

Background:
A novel familial arrhythmia syndrome, cardiac ryanodine receptor (RyR2) calcium release deficiency syndrome (CRDS), has recently been described. We evaluated a large and well characterized family to assess provocation testing, risk factor stratification and response to therapy in CRDS.

Methods:
We present a family with multiple unheralded sudden cardiac deaths and aborted cardiac arrests, primarily in children and young adults, with no clear phenotype on standard clinical testing.

Results:

Genetic analysis, including whole genome sequencing, firmly established that a missense mutation in
RYR2
, Ala4142Thr, was the underlying cause of disease in the family. Functional study of the variant in a cell model showed RyR2 loss-of-function, indicating that the family was affected by CRDS. EPS (Electrophysiological Study) was undertaken in 9 subjects known to carry the mutation, including a survivor of aborted sudden cardiac death, and the effects of flecainide alone and in combination with metoprolol were tested. There was a clear gradation in inducibility of nonsustained and sustained ventricular arrhythmia between subjects at EPS, with the survivor of aborted sudden cardiac death being the most inducible subject. Administration of flecainide substantially reduced arrhythmia inducibility in this subject and abolished arrhythmia in all others. Finally, the effects of additional metoprolol were tested; it increased inducibility in 4/9 subjects.

Conclusions:

The Ala4142Thr mutation of
RYR2
causes the novel heritable arrhythmia syndrome CRDS, which is characterized by familial sudden death in the absence of prior symptoms or a recognizable phenotype on ambulatory monitoring or exercise stress testing. We increase the experience of a specific EPS protocol in human subjects and show that it is helpful in establishing the clinical status of gene carriers, with potential utility for risk stratification. Our data provide evidence that flecainide is protective in human subjects with CRDS, consistent with the effect previously shown in a mouse model.
Weisfeiler-Leman in the Bamboo: Novel AMR Graph Metrics and a Benchmark for AMR Graph Similarity
Authors: Opitz Juri , Daza Angel , Frank Anette 
Published: December 2021

Abstract
Several metrics have been proposed for assessing the similarity of (abstract) meaning representations (AMRs), but little is known about how they relate to human similarity ratings. Moreover, the current metrics have complementary strengths and weaknesses: Some emphasize speed, while others make the alignment of graph structures explicit, at the price of a costly alignment step.
In this work we propose new Weisfeiler-Leman AMR similarity metrics that unify the strengths of previous metrics, while mitigating their weaknesses. Specifically, our new metrics are able to match contextualized substructures and induce n:m alignments between their nodes. Furthermore, we introduce a Benchmark for AMR Metrics based on Overt Objectives (Bamboo), the first benchmark to support empirical assessment of graph-based MR similarity metrics. Bamboo maximizes the interpretability of results by defining multiple overt objectives that range from sentence similarity objectives to stress tests that probe a metric’s robustness against meaning-altering and meaning- preserving graph transformations. We show the benefits of Bamboo by profiling previous metrics and our own metrics. Results indicate that our novel metrics may serve as a strong baseline for future work.
Planning with Learned Entity Prompts for Abstractive Summarization
Authors: Narayan Shashi , Zhao Yao , Maynez Joshua , Simões Gonçalo , Nikolaev Vitaly , McDonald Ryan 
Published: December 2021

Abstract
We introduce a simple but flexible mechanism to learn an intermediate plan to ground the generation of abstractive summaries. Specifically, we prepend (or prompt) target summaries with entity chains—ordered sequences of entities mentioned in the summary. Transformer-based sequence-to-sequence models are then trained to generate the entity chain and then continue generating the summary conditioned on the entity chain and the input. We experimented with both pretraining and finetuning with this content planning objective. When evaluated on CNN/DailyMail, XSum, SAMSum, and BillSum, we demonstrate empirically that the grounded generation with the planning objective improves entity specificity and planning in summaries for all datasets, and achieves state-of-the-art performance on XSum and SAMSum in terms of rouge. Moreover, we demonstrate empirically that planning with entity chains provides a mechanism to control hallucinations in abstractive summaries. By prompting the decoder with a modified content plan that drops hallucinated entities, we outperform state-of-the-art approaches for faithfulness when evaluated automatically and by humans.
Between-Class Earnings Inequality in 30 European Countries
Authors: Goedemé Tim , Paskov Marii , Weisstanner David , Nolan Brian 
Published: December 2021

Abstract
This article studies earnings inequality between social classes across 30 European countries. Class inequality in earnings is found across the board although there are some exceptions. However, the degree of class inequality varies strongly across countries being larger in Western and Southern European countries and smaller in Eastern and Northern European countries. Furthermore, we find that differences in class composition in terms of observed characteristics associated with earnings account for a substantial proportion of these between-class differences. Differences between classes in the returns to education and other characteristics play less of a role. In all these respects there is a sizeable cross-national variation. This points to important differences between countries in how earnings are structured by social class.
Between Foreigners, Strangers and Jews: The Changing Perception of Parisian Jews on the Eve of the 1306 Expulsion
Authors: Dermer Nureet 
Published: December 2021

Abstract
An unpublished document from late thirteenth-century Paris contains evidence of a Jewish-Christian public confrontation, on the one hand, and of Jewish-Christian economic criminal collaboration on the other. Using methods of micro-history, this article traces the story of Merot the Jew and his father-in-law, Benoait of St. Denis, who were caught attempting to smuggle merchandise by way of the River Seine. Their story is told in a verdict handed down by the parloir de Paris, the municipal judicial authority in charge of economic infractions. The parloir decreed the complete confiscation of Merot and Benoait’s merchandise on the grounds that “they were foreigners.” Taking this terminology as a point of departure, this paper tackles broader socio-economic aspects of belonging and foreignness among medieval Parisian Jews, and asks: in what ways were Jews considered “foreigners” in late thirteenth-century Paris? What were the implications of such a designation, and how did these perceptions change in the years leading up to the expulsion of 1306?
The Archae System Revisited: The Records of Indebtedness to Medieval Jews
Authors: Irwin Dean A. 
Published: December 2021

Abstract
This article examines on document acknowledging debt to Maruna, a Jewish woman, to John of Kent that was deposited in a chest in Canterbury in 1264. Using this document, the article examines what can be learned about the archae system in thirteenth-century England from the perspective of the documents which were produced there. A series of chests (Lat. pl. archae) were established across England following the introduction of the Articles of the Jewry (1194), which regulated the production, use, and storage of the records generated by Jewish moneylending activities in medieval England. Additionally, the Articles of the Jewry required that more general business transactions, such as the sale and purchase of property, also be recorded at the archae. This paper considers not only the legal and administrative structures which governed the production of such records but also how these systems manifested themselves within the documents which produced at the archae. Finally, it will consider the role that ritual and gender had to play in such transactions and the documents which recorded them.
Pawned Horses: Risk and Liability in Fourteenth Century German Small-Credit Market
Authors: Doron Aviya 
Published: December 2021

Abstract
Many Jewish-Christian credit transactions relied on pawns as collateral, which presumably eliminated the risk in the case of debtors’ default. However, keeping and maintaining certain pawns involved particular risks that further complicated these transactions. This paper focuses on live pawns, specifically horses, where the safekeeping of the animal involved far greater difficulties and risks than with other valuable objects that were pawned with Jews. By tracing how legal norms and practices addressed some of the unique risks attached to receiving horses as pawns, this article will outline the expectations both Jews and Christians had when engaging in credit transaction secured by horses. Relying on responsa literature, urban legislation, and court cases from the late thirteenth to mid-fourteenth centuries, this analysis will discuss some of the complications relating to liability over live pawns, with the goal of demonstrating how a specific type of pawn, and its unique risks and benefits, reflects previous assumptions and expectations regarding risk and trust.
The Sentence is Only the Beginning: Hiccups in the Cross-Border Execution of Judgments in the Euregion Meuse-Rhine
Authors: Keiler Johannes , Klip André 
Published: December 2021

Abstract
The cross-border execution of judgments remains difficult in practice for European Member States. This article seeks to analyze why this may be the case with regard to four different modalities of sentences: (1) prison sentences and other measures involving deprivation of liberty, (2) conditional sentences and alternative measures, (3) financial penalties and (4) confiscation orders. Based on a comparative analysis, this article investigates the problems at stake regarding the cross-border execution of judgements in Belgium, Germany and the Netherlands and identifies possible causes and explanations for these. The analysis shows that impediments to cooperation may inter alia stem from differences in national law and diverging national sentencing practices and cultures and may furthermore be related to a lack of possibilities for cooperation in the preliminary phase of a transfer. Moreover, some obstacles to cooperation may be country-specific and self-made, due to specific choices and approaches of national criminal justice systems.
The Tangled Path From Identifying Financial Assets to Cross-Border Confiscation. Deficiencies in EU Asset Recovery Policy
Authors: Ochnio Ariadna Helena 
Published: December 2021

Abstract
The article discusses the shortcomings of EU policy regarding cross-border asset recovery. The identified problem is a disjointed approach to the overlapping objectives of criminal proceedings: gathering evidence and securing assets for future confiscation. In the current EU legal framework, the process of recovery of assets, understood as a sequence of functionally related activities, lacks the continuity necessary to be effective. EU cross-border cooperation instruments in criminal matters do not meet the needs of this process, as they relate to separate investigative measures. Problems in this field have been indirectly reflected in the practice of Eurojust and the ejn. The article proposes a change in the perception of the initial phase of the asset recovery process, where the objectives of identifying and locating financial assets are combined with their provisional securing. This takes place under one mechanism of cross-border cooperation (an eio), prior to issuing a regular freeze or seizure order.
Speaking for Ourselves: The Ghanaian Encounter with European Missionaries – Sixteenth–Twenty-first Centuries
Authors: Eshun Daniel Justice 
Published: December 2021

Abstract
This paper (re)examines European missionary encounters with Ghanaians from the sixteenth – twenty-first centuries from Ghanaian perspectives. The paper makes three main arguments: first, European missionary endeavours were quite peripheral to ongoing indigenous religious activities and daily life, with the movement of Christianity from the periphery to the center of Ghanaian society a more recent phenomenon with political implications and concerns. Secondly, missionary and colonial decisions were often made in response to indigenous activities, not vice versa. And thirdly, this methodological approach of hearing African and European voices in dialogue serves as a much-needed corrective to favouring European perspectives within African mission history. Taken together, this provides fresh insights into questions of how/why Christianity went from the periphery under European missionary leadership to Ghana’s primary religion post-independence, offering differently nuanced understandings to concepts of mission while giving dignity and respect to the local context, people, and institutions.