bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Risks of Nonsteroidal Anti-Inflammatory Drugs on CKD
Authors: Wan Eric Yuk Fai , Yu Esther Yee Tak , Chan Linda , Mok Anna Hoi Ying , Wang Yuan , Chan Esther Wai Yin , Wong Ian Chi Kei , Lam Cindy Lo Kuen 
Published: April 2021

Background and objectives
There have been doubts about the association between nonsteroidal anti-inflammatory drug use and worsening kidney function, and whether there is a difference between risks of individual nonsteroidal anti-inflammatory drugs is presently unclear. Therefore, this study aimed to evaluate the association between nonsteroidal anti-inflammatory drug exposure and the risk of incident eGFR <60 ml/min per 1.73 m2 and compare the risks between nonsteroidal anti-inflammatory drug subtypes in the Chinese population.

Design, setting, participants, & measurements
From 2008 to 2017, a total of 1,982,488 subjects aged 18 years or older with baseline eGFR ≥60 ml/min per 1.73 m2 were enrolled in this retrospective cohort study. Multivariable Cox proportional hazards regression adjusted for each patient’s baseline characteristics was adopted to examine the association between nonsteroidal anti-inflammatory drug and incident eGFR <60 ml/min per 1.73 m2 or eGFR decline ≥30% with reference to baseline.

Results
After a median follow-up duration of 6.3 (interquartile range, 3.3–9.4) years, 271,848 cases (14%) of incident eGFR <60 ml/min per 1.73 m2 and 388,386 (21%) events of eGFR decline ≥30% were recorded. After adjusting for each patient’s baseline characteristics, nonsteroidal anti-inflammatory drug treatment was shown to be associated with a significantly higher risk of incident eGFR <60 ml/min per 1.73 m2 (hazard ratio, 1.71; 95% confidence interval, 1.67 to 1.75) and eGFR decline ≥30% (hazard ratio, 1.93; 95% confidence interval, 1.89 to 1.96) when compared with no nonsteroidal anti-inflammatory drug, with etoricoxib exhibiting the highest risk of eGFR<60 ml/min per 1.73 m2 (hazard ratio, 3.12; 95% confidence interval, 2.69 to 3.62) and eGFR decline ≥30% (hazard ratio, 3.11; 95% confidence interval, 2.78 to 3.48) and ibuprofen displaying the lowest risk of eGFR<60 ml/min per 1.73 m2 (hazard ratio, 1.12; 95% confidence interval, 1.02 to 1.23) and eGFR decline ≥30% (hazard ratio, 1.32; 95% confidence interval, 1.23 to 1.41).

Conclusions
Nonsteroidal anti-inflammatory drug exposure was associated with higher risks of incident eGFR <60 ml/min per 1.73 m2 and eGFR decline ≥30%. Highest risk was observed in etoricoxib users, and lowest risk was with ibuprofen.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2021_04_28_CJN18501120.mp3
Robot-assisted minimally invasive transforaminal lumbar interbody fusion versus open transforaminal lumbar interbody fusion: a retrospective matched-control analysis for clinical and quality-of-life outcomes
Authors: Chen Xiuyuan , Song Qingxin , Wang Kun , Chen Zhi , Han Yingchao , Shen Hongxing , Li Quan 
Published: April 2021

Aim:
To compare the screw accuracy and clinical outcomes between robot-assisted minimally invasive transforaminal lumbar interbody fusion (RA MIS-TLIF) and open TLIF in the treatment of one-level lumbar degenerative disease.
Materials & methods:
From May 2018 to December 2019, a consecutive series of patients undergoing robot-assisted minimally invasive one-level lumbar fusion procedures were retrospectively compared with matched controls who underwent one-level open TLIF procedures for clinical and quality-of-life outcomes.
Results:
A total of 52 patients underwent RA MIS-TLIF procedures (robot-assisted [RA] group) and 52 matched controls received freehand open TLIF procedures (open [OP] group). The RA group had more grade A screws with 96.2% one-time success rate of screw placement (p < 0.05). Besides, the RA group experienced less intraoperative blood loss and shorter length of hospital stay, while the OP group had shorter operative duration and cumulative radiation time (p < 0.001). What is more, the average VAS score for low back pain and ODI score in the RA group were lower than that in the OP group 1 month after operation (p < 0.05).
Conclusion:
The use of real-time, image-guided robot system may further expand the advantages of MIS-TLIF technique in terms of accuracy and safety.
Human papilloma virus in the urethra in HIV-infected men in the Рrimorsk region
Authors: Grigorian O. M. , Sklyar L. F. , Filipova, O. V. , Gavro E. V. , Beniova S. N. , Shchelkanov M. Yu. 
Published: April 2021

Objective of the study: identification of HPV and identification of the most common types in urethral swabs taken from HIV-1- infected men, as well as determination of the dependence of the presence of HPV in patients with HIV viral load (VL) and CD4 + T-lymphocyte count.Materials and methods. The study included 34 HIV-1-infected men being monitored at the Center for the Prevention and Control of AIDS and Infectious Diseases (Vladivostok). They were asked to undergo a urological examination, including the collection of urethral swabs, as well as a face-to-face interview to collect socio-demographic, behavioral and clinical-anamnestic data.Results. HIV-1-infected patients (34 people) included in the study were 25–60 (37,8±7,1) years old. HPV was detected in 23 (67,6%) patients aged 25–45 (37,8±5,5) years. The vast majority of patients with multiple HPV infection reported having had sex with three or more sexual partners and did not always use a condom, and 17.4% of the men surveyed said they never used one. In the past, 47.8% of HPV-positive patients used narcotic substances, and 30.4% of the respondents, at the time of the survey, were active users of psychoactive substances. In 23 HIV 1-infected men, 9 genotypes were identified — 6 (HPV-HP), 16, 18, 33, 35, 52, 53, 58, 73 (HPV-VR) — belonging to 5 types of HPV: AlphaPV-6, AlphaPV-7, AlphaPV-9, AlphaPV-10, AlphaPV-11. In 5 patients, coinfection of two genotypes was revealed, in 3 — two types of HPV. The most common genotype was HPV-16 (30,4%) and HPV-18 (26,1%), the least HPV-{6, 58, 73} (1/23≈4,3%). The presented results indicate the need to create diagnostic programs focused on early detection of cancer of the anogenital region in persons of both sexes in patients with immunodeficiency states, primarily in HIV 1-positive patients with HPV-HR.
Pemanfaatan Digital Marketing Pada Usaha Mikto Kecil dan Menengah (UMKM) di Kota Tangerang Selatan
Authors: Rozinah Siti , Meiriki Andri 
Published: April 2021

Micro, Small and Medium Enterprises (UMKM) have an important role in the pace of Indonesia's economy, especially in job creation and household empowerment that supports household income. The existence of UMKM is expected to be able to spur the economy amid the current economic slowdown. Utilization of the concept of marketing based on digital technology (digital marketing) provides hope for UMKM to develop into a center of economic strength. The development of digital technology enables UMKM to market their products online and conduct transactions through the online banking system as well. This study aims to see whether the implementation of digital marketing can have an influence on the sales volume of UMKM industry results, as well as to find out whether the use of digital marketing has a large influence on the development of UMKM businesses in South Tangerang City. This research was conducted with a qualitative research method to look deeper into the influence of the use of digital marketing in the development of UMKM businesses in the eyes of UMKM managers in South Tangerang City. The results showed that the use of digital marketing can increase UMKM sales by 30-50 percent, and digital marketing is able to expand their market share and at the same time reduce the promotional costs they incur, as well as being able to shorten the distance of UMKM interaction with their consumers
Comercio electrónico en el sector artesanal en Norte de Santander
Authors: Cortés Miranda Lina Andrea , Galeano Solano Angie Paola , Nader Sánchez Saray Daniela , Saboyá García Karen Dayana , Barrientos Monsalve Ender José 
Published: April 2021

El artículo está enfocado en el desarrollo de estrategias para el aprovechamiento de los recursos tecnológicos se nos ofrecen actualmente. Precisamente, el avance de estos ha planteado nuevos horizontes en diferentes aspectos del comercio electrónico, como lo es la venta y compra de productos de una forma más rápida y fácil tanto para el consumidor como para el vendedor. El comercio electrónico ha experimentado una notable evolución, pasando de ser un simple catálogo de productos o servicios, construido a partir de una página estática, a convertirse en un medio eficaz para realizar negocios, entonces, ¿se está aprovechando esta herramienta para la venta de artículos en Norte de Santander? el comercio electrónico es una herramienta que si se aprovecha puede traer los mejores beneficios para las empresas.
The effect of coexistence between larvae of Anopheles gambiae and Culex quinquefasciatus on larvicidal efficacy of Bacillus thuringiensis var. israelensis
Authors: Derua Yahya A. , Kweka Eliningaya J. , Kisinza William N. , Yan Guiyun , Githeko Andrew K. , Mosha Franklin W. 
Published: April 2021

Background: The efficacy of Bacillus thuringiensis var. israelensis (Bti) is affected by several factors including the species of the mosquito. Mosquito larvae of different species are found to coexist in larval breeding habitats. This study evaluated whether the coexistence between Anopheles gambiae and Culex quinquefasciatus affect the larvicidal activity of Bti.
Methods: Two parallel larval bioassay experiments were conducted to test A. gambiae sensu stricto (s.s) and C. quinquefasciatus larvae susceptibility to Bti. They were followed by three parallel bioassays in which A. gambiae s.s and C. quinquefasciatus larvae were mixed in different proportions such that the earlier species contributed three quarters, half and a quarter of the larvae in each testing cup respectively. In each bioassay, six Bti concentrations were tested in four replicates and repeated on three different days. Larvae mortality was scored 24 hours after application of Bti and subjected to Probit analysis.
Results: C. quinquefasciatus was significantly more susceptible to Bti than A. gambiae s.s at both lethal concentration values (LC50 and LC95). In coexisting scenario, LC50 of Bti was significantly lower when the proportion of C. quinquefasciatus exceeded 50%. No significant variation in susceptibility to Bti was observed at LC95 in any proportion of coexistence between the two species.
Conclusion: The findings show that larvae of C. quinquefasciatus were significantly more susceptible to Bti than those of A. gambiae s.s. Moreover, when larvae of the two species coexisted, there was a general trend of increase in sensitivity to Bti with higher proportion of C. quinquefasciatus. Although this increase in sensitivity of coexisting larvae to Bti is worth noting, our findings suggest that it will not impact larval control where A. gambiae s.s and C. quinquefasciatus coexist.
Evaluation of surface plasmon field-enhanced fluorescence spectroscopy for rapid measurement of progesterone concentration in bitches
Authors: Fontbonne Alain , Maenhoudt Cindy , Thoumire Sandra , Roos Juliette , Niewiadomska Zuzanna , Robiteau Guillaume , Rousselière Edwige , Buronfosse Thierry 
Published: April 2021

Abstract

OBJECTIVE
To compare progesterone (P4) concentrations measured with surface plasmon field-enhanced fluorescence spectroscopy (SPFS) and chemiluminescence immunoassay (CLIA) in serum and plasma samples of client-owned bitches of various ages and breeds and to determine reference ranges for P4 concentrations at various stages of the estrous cycle.

SAMPLES
102 serum samples and 104 plasma samples.

PROCEDURES
In experiment 1, 1 aliquot each of serum and plasma was analyzed for P4 concentration by use of SPFS incorporated in a veterinary-specific point-of-care immunologic analyzer and CLIA. In experiment 2, serum collected from bitches in various stages of the estrous cycle was analyzed for P4 concentration by use of SPFS to establish reference ranges for each stage.

RESULTS
In experiment 1, P4 concentrations measured by SPFS and CLIA were highly correlated (serum, r = 0.966; plasma, r = 0.968). In experiment 2, ranges of serum basal (proestrous) P4 concentrations (n = 114) and P4 concentrations at the estimated time of ovulation (76), during pregnancy or diestrus (107), and during the prepartum period (50) measured with SPFS were 0.42 to 1.46 ng/mL, 3.69 to 7.85 ng/mL, 11.73 to 28.24 ng/mL, and 1.54 to 3.22 ng/mL, respectively.

CONCLUSIONS AND CLINICAL RELEVANCE
Because serum and plasma P4 concentrations measured with SPFS were highly correlated with those measured with CLIA and ranges of serum P4 concentrations measured with SPFS for each of phase of the estrous cycle were well-defined for the large sample size, veterinarians may be able to accurately use this veterinary-specific point-of-care immunologic analyzer with SPFS methodology to determine P4 concentrations of bitches in their daily practice.
Numerical Simulation and Analysis of Airflow in the Condensing Zone of Compact Spinning with Lattice Apron
Authors: Saty Malik Y. H. , Akankwasa Nicholus T. , Wang Jun 
Published: April 2021

Abstract
The airflow field pattern in the condensing zone plays a vital role in the pneumatic compact spinning, which significantly affects the yarn's qualities. This study aimed to analyze the effects of the different negative air pressures on fiber condensing in compact spinning with lattice apron using ANSYS. The results of airflow simulations reveal that by increasing the negative pressure, the flow velocity increases, leading to a more tremendous increase in the transverse condensing effects. Additionally, a better convergence led to reduced fiber width and eliminated the spinning triangle. Experimental results showed that the three yarns spun with the highest negative pressure had better strength, hairiness, and evenness than those spun with lower negative pressure.
Effect of Experiential Quality and Experiential Satisfaction on Revisit Intention in Lake Toba
Authors: Rini Endang Sulistya , Sembiring Beby Karina Fawzeea , Absah Yeni 
Published: April 2021

Abstract
The purpose of this study is to look at the influence of experiential quality on revisit intention through experiential satisfaction. The population in this study is tourists, of an unknown population number, who have already visited Lake Toba. Based on Malhotra’s theory, with the number of respondents of 324, the sampling method used is accidental sampling. The data analysis in this study is descriptive analysis and statistical analysis of PLS-SEM using Smart-PLS software. The results of this study show that experiential quality has a positive and significant effect on experiential satisfaction variables. Experiential quality has a positive and significant effect on variable revisit intention, and experiential satisfaction has a positive and significant effect on variable revisit intention through experiential satisfaction. The implication of this research is that experience is an important thing to research where good and bad experiences can make tourists revisit to the visited tourist attractions.
Art, Death, and Science: The Skull in Dutch Still Life Painting
Authors: Sun Jiaqi (Angela) 
Published: April 2021

Vanitas is a type of still life popular in European art that usually includes items that symbolize the transience of life and the emptiness of earthly accomplishment. The most commonly depicted object in Vanitas images is a skull. In the 17 th‐century, vanitas still‐lifes flourished in the Netherlands and especially the city of Leiden. It has been generally agreed among scholars that this phenomenon was a result of Leiden’s unique cultural atmosphere. In 1575, when Leiden University was established, it quickly became one of the leading intellectual institutions in Europe, attracting an international community of renowned humanist scholars and scientists. Since the university was heavily under the influence of Calvinist and Neo‐Stoicist scholars, whose philosophies emphasized greatly the “brevity of life”, it has been accepted that this cultural atmosphere promoted the vogue for Vanitas Still lifes in Leiden. However, there is another strong intellectual force in the city that has been overlooked by art historians, the rapid development of scientific studies and the formation of ‘curiosity cabinets’, where natural and artistic artefacts were displayed together. There were a number of prominent scientists who researched and taught in Leiden University, and they often held labs and demonstrations of anatomy dissection for the public. Furthermore, according to several inventories from the time, people also collected skulls as precious objects. Hence, I would like to propose that the great interest in science, shared by scholars and the public, was an alternative factor that pushed Vanitas painting to its high point in Leiden.
Implementation of Outpatient Pharmacist-led Hypertension Management for Under-Resourced Patients: A Pilot Study
Authors: Stewart Brittany , Brody Aaron , Garwood Candice L. , Zhang Liying , Levy Phillip D. 
Published: April 2021

Background: The purpose of this study was to implement and evaluate a pharmacist-led hypertension (HTN) program for under-resourced patients discharged from the emergency department (ED) or screened at community health events who are lacking a regular primary care provider (PCP) relationship.
Methods: This was a single arm, prospective, pilot study to recruit patients from the Detroit Medical Center (DMC) Sinai Grace Hospital (SGH) ED and community health events. The outpatient pharmacist-led transitional care clinic (TCC) was implemented through a collaborative practice agreement (CPA) with ED physicians. Eligible patients 18 to 60 years with elevated blood pressure (BP) (> 140/90 mmHg) and lacking a PCP relationship were referred to the TCC for HTN management. The primary outcome measure was change in systolic and diastolic BP (SBP and DBP). Difference in BP values was evaluated using Wilcoxon Signed Ranks test and descriptive statistics were used to explain demographic data.
Results: There were 116 patients enrolled May 2017 to August 2018; 44 (37.9%) completed visit one [cohort 1], 30 (25.9%) completed at least three visits [cohort 2], and 16 (13.8%) completed five visits [cohort 3]. Most patients were African American (AA) 97.7%, 47.8% were male, and an average of 42.11 (SD 9.70) years. For cohorts 2 and 3, there was significant reduction in BP between TCC visits one and two and the reduction was maintained through five visits for patients that remained in the study. Patients who completed five visits (n=16) showed a significant change from visit one to visit five in SBP of -23 mmHg (p=0.002) and achieved BP goal with an average SBP 139 mmHg (SD 19.33) and DBP 90 mmHg (SD 10.17).
Conclusion: The pharmacist-led TCC was successfully implemented. Outpatient pharmacists collaborating with ED physicians increased access to HTN management with a positive impact on BP outcomes in an under-resourced population.
PENSAR TEOLOGICAMENTE AS RELIGIÕES A PARTIR DA AUTOCOMPREENSÃO CRISTÃ
Authors: Lopes Gonçalves Paulo Sérgio , Moraes Negro Felipe de 
Published: April 2021

Objetiva-se neste artigo pensar teologicamente as religiões a partir da autocompreensão cristã, categoria trazida por Andrés Torres Queiruga, docente emérito da Universidade de São Tiago de Compostella. Justifica-se esse objetivo o fato de que a teologia das religiões, como novo modo de fazer teologia, surgida com Paul Knitter, possibilitou mais de uma maneira de elaborar esse tipo de teologia. Por isso, tornou-se possível uma teologia cristã do pluralismo religioso com Jacques Dupuis e uma teologia inter-religiosa com Claude Geffré, teólogos católicos que consolidaram como modo de produção uma forma de pensar teologicamente as religiões. O mencionado teólogo espanhol, desde os primórdios da sistemática teologia das religiões se pôs a pensar as religiões, tomando a revelação de Deus, concebida a partir da “maiêutica histórica”, pela qual é possível conceber a veracidade das religiões desde a clara autocompreensão cristã, a fim de que não se efetive um universalismo indiferenciado e uniforme, concentre-se na cristologia e na soteriologia e se visualize o diálogo e o encontro entre as religiões. Para atingir esse objetivo, haverá a exposição referente à teologia das religiões elaborada por Paul Knitter e seus desdobramentos presentes nas elaborações do teólogo belga e do teólogo francês supracitados, para, em seguida, apresentar como o teólogo espanhol pensa teologicamente as religiões. Palavras-chave: teologia; religiões; diálogo; encontro.
Análisis comparativo del componente administrativo y de los procesos de desinfección utilizados en dos plantas de tratamiento de agua potable
Authors: Velandia Medina Laura , De Plaza Juan Sebastián , Pulgarín Diego Alejandro 
Published: April 2021

Este artículo contiene el análisis comparativo realizado entre dos plantas de tratamiento de agua potable (PTAP), una que abastece de agua a una parte de Bogotá, Colombia y otra en Boston, Estado Unidos de América (EE. UU.). El análisis se enfoca en tres aspectos: el tratamiento implementado en el agua que ingresa a las PTAP, el desinfectante utilizado en las plantas y el modelo administrativo utilizado en cada país. De acuerdo con estudios desarrollados en la Carroll Water Treatment Plant CWTP), al implementar el sistema de desinfección por ozonización se obtienen cambios notables y considerables en las características del agua, su sabor y color, un aumento en la inactivación de patógenos, así como una dramática reducción en los subproductos de la desinfección. Por otra parte, contar con varias entidades que intervengan en la administración financiera del recurso hídrico proporciona un mejor control y vigilancia de este, como en EE. UU. Asimismo, la prevención de la contaminación del agua parece una directiva de manejo más sabia y prudente que la limpieza de nuestras fuentes de agua en el futuro.
Estudio exploratorio de medición de material particulado respirable en biciusuarios de Engativá, Bogotá
Authors: Moya Rodríguez Lina Valeria , Álvarez Cepeda Daniel Alexander , Meneses Velosa Sonia Lucila 
Published: April 2021

En Bogotá se realizan aproximadamente 900.000 viajes en bicicleta a diario, siendo este un medio de movilidad sostenible y amigable con el ambiente. Los usuarios que utilizan este medio de transporte se exponen a una deficiente calidad del aire, que ha traído como consecuencia altos niveles de enfermedades respiratorias agudas, generadas por la exposición a elevadas dosis de material particulado que se encuentra suspendido en el aire. En la Universidad Libre sede Bosque Popular, aproximadamente 500 estudiantes, docentes y administrativos se movilizan en bicicleta, de los cuales un 60 % transitan por la ruta que va desde el barrio Bonanza, Avenida Medellín (calle 80), avenida Rojas, hasta la Universidad; lugar que no cuenta con una ciclorruta y por lo tanto los biciusuarios se encuentran expuestos a respirar más cantidades de este contaminante. El presente trabajo se centra en el análisis, modelado de los resultados obtenidos de la medición de material particulado respirable por los biciusuarios en su trayecto cotidiano en la ruta anteriormente mencionada y la comparación con los límites permisibles, lo que permite identificar los niveles de riesgo a los cuales ellos están expuestos. La complejidad de este experimento radica en el “ambiente” de toma de muestras, entendido este como las rutas de movilidad ya que son espacios abiertos donde existe una serie de aspectos no controlados en contraste con los muestreos de higiene en espacios laborales no rmales y la aplicación de un estudio de higiene industrial llevado al tema de movilidad en bicicleta, el cual no se ha realizado antes.