bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uji Daya Terima dan Nilai Gizi Makanan Pendamping ASI (MPASI) Berbahan Pangan Lokal di Posyandu Wilayah Kerja Puskesmas Sidosermo Kota Surabaya
Authors: Prabawani Yuni 
Published: December 2021

Tujuan penelitian ini adalah tersusunnya 15 macam MPASI yang memenuhi syarat Gizi, mengetahui nilai gizi MPASI dan daya terimanya. Penelitian ini menggunakan metode eksperimental dengan purposive sampling dan kriteria inklusi usia 6-24 bulan, sehat dan mengikuti penimbangan di Posyandu setempat. Bahannya adalah 15 MP ASI @ 20 porsi dengan peralatan masak sesuai yang dibutuhkan dan formulir Comstok, alat tulis dan air putih untuk mengetahui daya terima panelis, yaitu bayi usia 6-8 bulan, 9-12 bulan dan >12 bulan.di 4 Posyandu lokasi penelitian. Pembuatan MPASI dilaksanakan di Laboratorium Diit UPT Laboratorium Gizi Dinas Kesehatan Provinsi Jawa Timur. Sedangkan uji daya terima dilaksanakan di 4 posyandu wilayah Puskesmas Sidosermo. Kandungan Vitamin C MPASI diuji dengan Iodometri di UPT Laboratorium Gizi dan untuk zat gizi lainnya menggunakan Nutrisurvey. Sedangkan uji daya terima menggunakan Comstok. Hasilnya diperoleh 15 resep MPASI, dengan nilai gizi tertinggi pada MP ASI umur 6-8 bulan kandungan protein tertinggi terdapat pada Bubur Batel (8 gram). Sedangkan untuk kandungan Vitamin C tertinggi pada bubur Payam (7.04 mg) dan Fe tertinggi pada Bubur Totel (1.4 mg). Kandungan Zink tertinggi 0.5 mg pada bubur Payam, bubur Batel dan bubur Totel. MPASI kelompok usia 9-12 bulan kandungan Protein tertinggi (7.8 gram), Vitamin C tertinggi (6.18 mg), Fe tertinggi (2.3 mg) dan Zink (1.2 mg) tertinggi ada pada bubur Bijay. MP ASI kelompok usia >12 bulan kandungan energi( 212 kcal), protein (9.5 gram), lemak (23 gram) dan vitamin C (17,6 mg) tertinggi terkandung pada menu nasi, Nugget Lele, Mendol Tempe, Sayur Kelor Wortel. Penggunaan bahan pangan lokal berbagai jenis ikan dan sayuran pada pembuatan MPASI ini menciptakan MP ASI dengan nilai gizi yang tinggi baik dari kandungan protein, Fe, Zink dan vitamin C sehingga sangat bagus untuk meningkatkan asupan protein, Fe , Zink dan Vitamin C alamiah untuk anak 6 – 24 bulan. MPASI yang paling disukai adalah krupuk pangsit udang 75% habis terkonsumsi (15 panelis), dan yang paling tidak disukai adalah bubur Bijay utuh 100% (1 panelis). Kesimpulannya MPASI yang dihasilkan adalah 10 resep makanan utama dan 5 resep makanan selingan, berbahan pangan lokal mengandung zat gizi energi, protein, Fe, Zink dan Vitamin C yang tinggi dan dapat diterima oleh panelis, diantaranya adalah Burikli, Bujasay dan nasi nugget Lele mendol tempe sayur kelor wortel.
KELAS EDUKASI DAN KONSELING SYNDROME MENOPAUSE PADA MENOPAUSE DI DESA JELANTIK
Authors: Nur Coryah Fitra Arsy 
Published: December 2021

Syndrom menopause dialami oleh banyak wanita hampir di seluruh dunia, sekitar 70-80% wanita Eropa, 60% di Amerika, 57% di Malaysia, 18% di Cina dan 10% diJepang dan Indonesia. Berdasarkan data WHO jumlah wanita menopause di Asia melonjak dari 107 juta jiwa akan menjadi 373 juta jiwa, SehinggaAsia merupakan wilayah dengan jumlah perempuan bergejala awal menopause tertinggi di dunia.Menurut Depkes RI (2009) hingga saat ini wanita Indonesia yang memasuki masa menopause sebanyak 7,4% dari populasi. Selain itu, Depkes RI memperkirakan penduduk Indonesia pada tahun 2020 akan mencapai 262,6 juta jiwa dengan jumlah wanita yang hidup dalam usia menopause sekitar 30,3 juta jiwa dengan usia rata-rata 49 tahun yang mengalami menopause. Jumlah tersebut meningkat menjadi 11% pada 2005, Kemudian, naik lagi sebesar 14% pada 2015.Desa Jelantik wilayah kerja Puskesmas ubung Kabupaten Lombok Tengah memiliki 10 posyandu lansia, yang sampai saat ini aktif melaksanakan kegiatan yang menunjang kesehatan lansia. Jumlah Ibu-ibu yang telah mengalami menopause usia 40 – 72 tahun yaitu sebanyak 516 yang mengikuti posyandu lansia dan tersebar di wilayah kerja puskesmas ubung. Hasil Pelaksanaan kegiatan pengabdian masyarakat diperoleh 50 responden ibu menopause yang menikuti pelaksanaan kelas edukasi dan konseling syndrome menopause. Hasil evaluasi menggunakan kuesioner tingkat kecemasan dan syndrome menopause. Syndrome menopause yang dialami ibu termasuk dalam kategori sedang sebanyak 20 orang (40%), sedangkan dari hasil konseling bahwa ibu menopause sering mengalami kecemasan sebanyak 22 orang (44%). Pada saat evaluasi materi 85 % peserta, mampu menjawab pertanyaan tentang syndrome menopause yang dialam
Medication-enhanced psychotherapy for posttraumatic stress disorder: Recent findings on oxytocin’s involvement in the neurobiology and treatment of posttraumatic stress disorder
Authors: Preckel Katrin , Trautmann Sebastian , Kanske Philipp 
Published: December 2021

Background
Traumatic experiences may result in Posttraumatic Stress Disorder (PTSD), which is characterized as an exaggerated fear response that cannot be extinguished over time or in safe environments. What are beneficial psychotherapeutic treatment options for PTSD patients? Can oxytocin (OXT), which is involved in the stress response, and safety learning, ameliorate PTSD symptomatology and enhance psychotherapeutic effects? Here, we will review recent studies regarding OXT’s potential to enhance psychotherapeutic therapies for PTSD treatment.

Method
We conducted a literature review on the neurobiological underpinnings of PTSD especially focusing on OXT’s involvement in the biology and memory formation of PTSD. Furthermore, we researched successful psychotherapeutic treatments for PTSD patients and discuss how OXT may facilitate observed psychotherapeutic effects.

Results
For a relevant proportion of PTSD patients, existing psychotherapies are not beneficial. OXT may be a promising candidate to enhance psychotherapeutic effects, because it dampens responses to stressful events and allows for a faster recovery after stress. On a neural basis, OXT modulates processes that are involved in stress, arousal and memory. OXT effectively counteracts memory impairments caused by stress and facilitates social support seeking which is a key resilience factor for PTSD and which is beneficial in psychotherapeutic settings.

Conclusion
OXT has many characteristics that are promising to positively influence psychotherapy for PTSD patients. It potentially reduces intrusions, but preserves memory of the event itself. Introducing OXT into psychotherapeutic settings may result in better treatment outcomes for PTSD patients. Future research should directly investigate OXT’s effects on PTSD, especially in psychotherapeutic settings.
Zachować decorum. Nowa ekspozycja stała w Muzeum i Miejscu Pamięci w Sobiborze
Authors: Wóycicka Zofia 
Published: December 2021

Jesienią 2020 r. na terenie dawnego niemieckiego ośrodka zagłady SS-Sonderkommando Sobibor otwarto nową ekspozycję muzealną dokumentującą historię tego miejsca oraz upamiętniającą jego ofiary. Muzeum jest ulokowane w nowym, wybudowanym specjalnie w tym celu, minimalistycznym budynku. Wystawa ma charakter ściśle dokumentalny; bardzo oszczędnie korzysta z multimediów i wystrzega się wszelkich form inscenizacji historii, które kuratorzy uznali za niestosowne. Nie ma ona sztucznie eskalować emocji, ale ma stanowić miejsce „informacji, refleksji i żałoby”. Mimo swej prostoty jest niezwykle nowoczesna i podąża za światowymi trendami w dziedzinie upamiętnienia masowych zbrodni, w tym przede wszystkim zbrodni drugiej wojny światowej i Holocaustu.
Prezentacja opiera się na wiedzy pozyskanej podczas prowadzonych od 2000 r. prac archeologicznych. Pozwoliły one zweryfikować wiele informacji dotyczących topografii i historii obozu. Wydobyły również na światło dzienne tysiące artefaktów, które stały się trzonem nowo powstałej ekspozycji. Ma ona stanowić wprowadzenie do wizyty w miejscu historycznym i ułatwić zwiedzającym „czytanie zastanego krajobrazu”. Sam teren obozu czeka jednak jeszcze na uporządkowanie i upamiętnienie.
Repercussões fisiopatológicas, clínicas e tratamento da Encefalopatia de Wernicke: uma revisão
Authors: Fonseca Gustavo Soares Gomes Barros , Assunção Izabely Lima , Pacheco Luyla Oliveira Paes Landim , Freitas Júnior Wellington Ubaldino de , Trindade Patrielly Oliveira , Sodré Neto Segundo Ademar , Rego Cecília Pessoa Almeida , Silva Janyne Daniel da Cunha França da , Aguiar Rebeca Carvalho de , Borges Fernando de Abreu , Coelho Claudia Nery do Nascimento , Costa Ana Clara Nóbrega , Garcia Ana Clara Rocha , Freire Vivianne Maria Laranjeiras Monte , Marinho Luana Caroline Oliveira , Lima Pedro de Lacerda , Andrade Pietra Possapp , Maia Ana Vitória Feitosa Barroso , Bonfim Lais Lima , Silva Mikael Coutinho , Carvalho Bárbara Nussrala , Carmo Fernanda Soares Rezende , Silva Vanessa Marques da , Abreu David Brusaca , Leite Maria Julia Fonseca Lima , Machado Paula Soares , Costa Arthur Brício Silva , Gonçalves Rafael Pavão 
Published: December 2021

Dentre as encefalopatias, algumas vêm sendo mais estudadas nas últimas décadas, como a encefalopatia de Wernicke (EW), a qual é um conjunto de sinais e sintomas neuropsiquiátricos que resultam de uma deficiência nutricional de tiamina. Essa pesquisa ​trata-se de uma revisão bibliográfica sistemática, do tipo quantitativa, que utilizou as plataformas PubMed, Scientific Eletronic Library On-line (SciELO) e Google Scholar como base de dados para pesquisa dos artigos científicos. Foram utilizadas literaturas publicadas com recorte temporal de 2016 a 2021, na língua inglesa que abordavam a encefalopatia de Wernicke e seus aspectos fisiopatológicos e clínicos. Constatou-se, portanto, que a deficiência da tiamina (vitamina B1) é capaz de levar o paciente a desenvolver a encefalopatia de Wernicke, quando a doença se associa à amnésia anterógrada. Ademais, a condição subjacente descrita na EW é o alcoolismo. Por conseguinte, altas doses da tiamina parenteral em pacientes de alto risco são primordiais para a melhora gradativa do paciente.
Exercício físico e hábitos alimentares em idosos: uma reflexão teórica
Authors: Medeiros Raul José de Araújo , Reis Luciana Araújo dos , Brito Flávia Rocha , Assis Wagner Couto , Guimarães Frank Evilácio de Oliveira , Melo Sílvio Andrade , Reis Luana Araújo dos 
Published: December 2021

Objetivo: Analisar, a partir da literatura, a prática de exercício físico e hábitos alimentares nos Idosos. Metodologia: Trata-se de um ensaio teórico de caráter reflexivo, realizado por meio de uma revisão bibliográfica não sistemática, com abordagem qualitativa. A coleta dos dados foi realizada através de busca online dos artigos nas bases de dados: google acadêmico, biblioteca eletrônica científica online (SCIELO), centro nacional de informações sobre biotecnologia (NCBI) e PUBMED, utilizando os descritores: exercícios físicos, hábitos alimentares, idosos, bem-estar, envelhecimento, e suas respectivas traduções padronizadas nos descritores em ciências da saúde (DECS). Como critérios de inclusão para seleção dos materiais foram considerados: artigos nos idiomas inglês e português, publicados no período de 2010 a 2020, disponíveis na integra e cujos resultados abrangessem o tema desta pesquisa. Resultados: A análise da literatura foi disposta em cinco categorias temáticas, a saber: Processo de envelhecimento; Envelhecimento saudável; Exercício físico; Qualidade de vida da pessoa idosa; e, Hábitos alimentares. Considerações Finais: A prática de exercício físico e hábitos alimentares saudáveis devem ser estimuladas nos Idosos, tendo em vista seu comprovado impacto na qualidade de vida destes.
A depressão infantil e o pedagogo em cena
Authors: Carvalho Tayse Cardoso Ferreira , Teixeira Zenaide Dias , Vilela Paula Rey , Santos Juscélia Paiva dos 
Published: December 2021

O presente trabalho tem como finalidade apresentar estudo de campo sobre a depressão infantil e o processo de ensino-aprendizagem, buscando, mais especificamente, discutir a importância do papel do professor. Diante de sua recente comprovação na infância, muitas vezes a depressão infantil passa despercebida. E por afetar muitos aspectos da vida da criança, inclusive o processo de ensino-aprendizagem, partimos do pressuposto de que o professor possa exercer um papel fundamental na identificação da criança acometida pela depressão, o que é um grande desafio. Para isso, realizamos uma pesquisa de campo, com aplicação de um questionário por meio do Google Forms para 29 estudantes do último semestre do curso de pedagogia de uma universidade pública no estado de Goiás, buscando perceber os conhecimentos dos futuros professores a respeito do tema. Os resultados da pesquisa demonstram que apesar de julgarem como importante que sua formação contemple conhecimentos básicos sobre a depressão infantil, a maioria dos estudantes, que estão no último semestre do curso de pedagogia e, portanto, em breve estarão em sala de aula, avaliam as orientações recebidas sobre o tema como insuficientes, portanto, não se sentem preparados para identificar ou lidar com crianças acometidas pela doença. Nesse sentido, chegamos à conclusão de que é necessário ampliar os conhecimentos sobre este transtorno, sobre seus sintomas e como ocorre na infância. Assim, o professor poderá auxiliar muitos de seus alunos a receberem um maior cuidado, alertar os responsáveis para que se possa procurar ajuda profissional adequada e a criança poderá receber tratamento o mais breve possível. Quanto antes ela for encaminhada para profissionais, mais resultados positivos são manifestados no tratamento e os danos à vida da criança, bem como ao processo de ensino-aprendizagem, podem ser significativamente minimizados.
O impacto da terapêutica estética na qualidade de vida de mulheres portadoras do melasma
Authors: Silva Daniela Aparecida Martins da , Santos Jeane Rocha 
Published: December 2021

O melasma é resultado da produção excessiva de melanina, principal pigmento que constitui a coloração da pele. Possui causa multifatorial e acomete áreas fotoexpostas do corpo, como o face. O melasma impacta diretamente na autoestima dos pacientes acometidos, impactando na sua qualidade de vida e convívio social. O objetivo é analisar os benefícios dos tratamentos estéticos na redução do melasma para melhoria da qualidade de vida de mulheres. Trata-se de uma pesquisa descritiva de natureza bibliográfica. Os resultados pretendem demostrar a eficácia do tratamento e a melhoria da autoestima de portadoras de melasma. Os tratamentos eficazes trazem benefícios na qualidade de vida dos portadores de melasma. Sugere-se que novos estudos acerca do tema sejam realizados e que estas pesquisam possam apresentar informações sobre os tratamentos mais efetivos e como eles atuam no clareamento do melasma.
A Novel Chondroitin AC Lyase With Broad Substrate Specificity From Pedobacter rhizosphaerae: Cloning, Expression, and Characterization
Authors: Zhou Li-Jian , Guo Li-Bin , Wei Wei , Lv Zhi-Xiang , Zhang Ye-Wang 
Published: December 2021

Chondroitin AC lyase (ChSaseAC) is one of the essential polysaccharides lyases in low molecular chondroitin sulfate production. In this work, a novel PrChSaseAC from Pedobacter rhizosphaerae was successfully cloned, expressed in Escherichia coli. After optimizing the induction, the recombinant PrChSaseAC could be expressed efficiently at 0.1 mM IPTG, 25°C, and 12 h induction. Then, it was purified with Ni-NTA affinity chromatography. The characterization of the purified PrChSaseAC showed that it had high specific activity and good storage stability, which would favor the production of low molecular weight chondroitin sulfate. It also displayed activity toward chondroitin sulfate C and hyaluronic acid. PrChSaseAC had the highest activity at pH 7.5, 37°C, 10 mM Ca2+, and 5 mg/ml of chondroitin sulfate A. Molecular docking of substrate and enzyme showed the interactions between the enzyme and substrate; it revealed that the enzyme showed high activity to CS-A and hyaluronic acid, but lower activity to CS-C attributed to the structure of the binding pocket. The high stability and specific activity of the enzyme will benefit the industrial production or clinical treatment.
Case Report: Abnormal ECG in a Patient With Acute Pancreatitis
Authors: Long Yunxiang , Tang Manyun , Wang Jie , Liu Hui , Jian Zhijie , Li Guoliang , Liu Chang 
Published: December 2021

Background: Both acute pancreatitis and acute myocardial infarction (AMI) are rapidly progressive and frequently fatal diseases that can be interrelated and lead to a vicious cycle for further problems. The concomitant occurrence of AMI and acute pancreatitis is rare but critical, and efficient diagnosis and treatment of such patients are challenging.Case Summary: We reported an uncommon case of abnormal ECG findings in a 63-year-old woman with acute pancreatitis. The patient exhibited increased biomarkers of myocardial injury, such as creatine kinase-MB (CK-MB) and troponin T, as well as ST segment elevation in inferior leads II, III, and aVF. Both of these have been previously observed in patients with acute abdomen in the absence of ST-segment elevation myocardial infarction (STEMI), including pancreatitis. In addition, lacking complaints of chest pain or tightness was also supportive of this idea. Echocardiography indicated abnormalities in the functioning of the left inferior posterior wall segments and decreased overall systolic function of the left ventricle with a 51% ejection fraction. Eventually, AMI was diagnosed after coronary computed tomography angiography (CCTA) showing critical stenosis of the right coronary artery and left anterior descending artery segments. The patient was urgently transferred to intensive care unit and was treated with anticoagulation, antiplatelet aggregation, lipid-lowering and other palliative drugs.Conclusion: Concomitant acute pancreatitis and AMI are often considered to be critical conditions with a poor prognosis. Therefore, it is important to rapidly identify this condition and consider transferring patients for multidisciplinary supportive care.
A Phenotyping of Diastolic Function by Machine Learning Improves Prediction of Clinical Outcomes in Heart Failure
Authors: Kameshima Haruka , Uejima Tokuhisa , Fraser Alan G. , Takahashi Lisa , Cho Junyi , Suzuki Shinya , Kato Yuko , Yajima Junji , Yamashita Takeshi 
Published: December 2021

Background: Discriminating between different patterns of diastolic dysfunction in heart failure (HF) is still challenging. We tested the hypothesis that an unsupervised machine learning algorithm would detect heterogeneity in diastolic function and improve risk stratification compared with recommended consensus criteria.Methods: This study included 279 consecutive patients aged 24–97 years old with clinically stable HF referred for echocardiographic assessment, in whom diastolic variables were measured according to the current guidelines. Cluster analysis was undertaken to identify homogeneous groups of patients with similar profiles of the variables. Sequential Cox models were used to compare cluster-based classification with guidelines-based classification for predicting clinical outcomes. The primary endpoint was hospitalization for worsening HF.Results: The analysis identified three clusters with distinct properties of diastolic function that shared similarities with guidelines-based classification. The clusters were associated with brain natriuretic peptide level (p &lt; 0.001), hemoglobin concentration (p = 0.017) and estimated glomerular filtration rate (p = 0.001). During a mean follow-up period of 2.6 ± 2.0 years, 62 patients (22%) experienced the primary endpoint. Cluster-based classification predicted events with a hazard ratio 1.68 (p = 0.019) that was independent from and incremental to the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) risk score for HF, and from left ventricular end-diastolic volume and global longitudinal strain, whereas guidelines-based classification did not retain its independent prognostic value (hazard ratio = 1.25, p = 0.202).Conclusion: Machine learning can identify patterns of diastolic function that better stratify the risk for decompensation than the current consensus recommendations in HF. Integrating this data-driven phenotyping may help in refining prognostication and optimizing treatment.
Sequential Coupling Shows Minor Effects of Fluid Dynamics on Myocardial Deformation in a Realistic Whole-Heart Model
Authors: Brenneisen Jochen , Daub Anna , Gerach Tobias , Kovacheva Ekaterina , Huetter Larissa , Frohnapfel Bettina , Dössel Olaf , Loewe Axel 
Published: December 2021

Background: The human heart is a masterpiece of the highest complexity coordinating multi-physics aspects on a multi-scale range. Thus, modeling the cardiac function in silico to reproduce physiological characteristics and diseases remains challenging. Especially the complex simulation of the blood's hemodynamics and its interaction with the myocardial tissue requires a high accuracy of the underlying computational models and solvers. These demanding aspects make whole-heart fully-coupled simulations computationally highly expensive and call for simpler but still accurate models. While the mechanical deformation during the heart cycle drives the blood flow, less is known about the feedback of the blood flow onto the myocardial tissue.Methods and Results: To solve the fluid-structure interaction problem, we suggest a cycle-to-cycle coupling of the structural deformation and the fluid dynamics. In a first step, the displacement of the endocardial wall in the mechanical simulation serves as a unidirectional boundary condition for the fluid simulation. After a complete heart cycle of fluid simulation, a spatially resolved pressure factor (PF) is extracted and returned to the next iteration of the solid mechanical simulation, closing the loop of the iterative coupling procedure. All simulations were performed on an individualized whole heart geometry. The effect of the sequential coupling was assessed by global measures such as the change in deformation and—as an example of diagnostically relevant information—the particle residence time. The mechanical displacement was up to 2 mm after the first iteration. In the second iteration, the deviation was in the sub-millimeter range, implying that already one iteration of the proposed cycle-to-cycle coupling is sufficient to converge to a coupled limit cycle.Conclusion: Cycle-to-cycle coupling between cardiac mechanics and fluid dynamics can be a promising approach to account for fluid-structure interaction with low computational effort. In an individualized healthy whole-heart model, one iteration sufficed to obtain converged and physiologically plausible results.