bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal Perception of Breastfeeding in Children with Unilateral Cleft Lip and Palate: A Qualitative Research Work
Authors: Cerón-Zapata Ana María , Martínez-Delgado María Cecilia , Calderón-Higuita Gloria Emilia 
Published: December 2021

Abstract
Background : Unilateral cleft lip and / or palate (UCLP) is one of the most common congenital craniofacial difference. The objective of this study was to describe maternal perception of breastfeeding in children with unilateral cleft lip and palate and to assess the role of breastfeeding counseling. Methods : Qualitative descriptive method and phenomenological analysis were used to analyze the narratives. 28 mothers of patients with nonsyndromic UCLP treated with nasoalveolar molding (NAM) between April 2015 and April 2018 were strategically selected and interviewed after NAM treatment. Framework analysis was conducted for qualitative data. The CES University ethical committee approved the study. Results : The findings resulted in six main categories: First contact with the CLP program, access to early diagnosis and timely treatment, perceptions of parents about health personnel on breastfeeding of CLP patients, perceptions of mothers toward breastfeeding, perception of advantages and disadvantages of the NAM technique regarding breastfeeding and assessment of the CLP program. The interviewed mothers, both prenatally and postnatally, stated the advantages of initiating the process prenatally. There are still difficulties for reaching a timely diagnosis. Several mothers stated that health professionals and assistants determined the hospitalization, installation of a nasogastric tube or feeding through a baby bottle or syringe, which prevented the first contact between mother and child. Even though the breastfeeding process is difficult for these mothers, they acknowledged its immense advantages. Interviewed mothers considered the use of the NAM advantageous as the obturator allowed a better bottle-feeding process. The program generates satisfaction, motivation, expectations and happiness to the mothers who initiated this therapy with their children. Conclusion : The participants related difficulties with breastfeeding. Mothers acknowledged the clinical results when using the NAM obturator, as well as the support provided by the breastfeeding consultant.
The Role of Hyperleptinaemia and Low Values of Interleukin 10 in De Novo DSA Production After Kidney Transplantation
Authors: Dedinská Ivana , Kantárová Daniela , Machaleková Katarina , Graňák Karol , Vnučák Matej , Laca Ľudovít , Mokáň Marián 
Published: December 2021

Abstract
Background
White adipose tissue secretes a number of peptide hormones. The aim of this paper was to determine the role of leptin, adiponectin and interleukin-10 and interleukin-6 on the development of graft rejection in protocol biopsy after kidney transplantation.
Methods
In a prospective analysis (n = 104), we monitored the values of leptin, adiponectin, IL-6, and IL-10 prior to the transplantation and in the 3rd month after the transplantation. The protocol biopsy of the graft was performed in the 3rd month after the transplantation. The group was divided into the following according to the biopsy result: negative result, IFTA 1, borderline, and DSA positive.
Results
After adjusting for the differences in the baseline recipient and donor characteristics, we identified the hyperleptinaemia baseline (HR = 2.0444, P = 0.0341) and month 3 (HR = 49.8043, P < 0.0001) as independent risk factors for borderline changes in the protocol biopsy. The hyperleptinaemia baseline (HR = 7.4979, P = 0.0071) and month 3 (HR = 9.7432, P = 0.0057) are independent risk factors for de novo DSA positivity. A low value of IL-10 month 3 is a risk factor for de novo DSA positivity (HR = 3.0746, P = 0.0388).
Conclusions
Higher leptin levels and low values of IL-10 might play a role in rejection and de novo DSA production.
Detection of EGFR Mutation Distribution and Transcriptional Variants in IDH-Wildtype High-Grade Gliomas Using a Next-Generation Sequencing Oncopanel
Authors: Higa Nayuta , Akahane Toshiaki , Hamada Taiji , Yonezawa Hajime , Uchida Hiroyuki , Makino Ryutaro , Watanabe Shoji , Takajo Tomoko , Yokoyama Seiya , Kirishima Mari , Fujio Shingo , Hanaya Ryosuke , Tanimoto Akihide , Yoshimoto Koji 
Published: December 2021

Abstract
\Purpose: To detect the epidermal growth factor receptor gene (EGFR) mutation profile and transcriptional variants in high-grade gliomas (HGGs), we sequenced EGFR and evaluated the EGFR splicing profile using a next-generation sequencing (NGS) oncopanel. Methods: We analyzed 124 HGGs—10 grade Ⅲ IDH-wildtype anaplastic astrocytomas (AAs) and 114 grade Ⅳ IDH-wildtype glioblastomas (GBMs). Results: The EGFR mutations were observed in 6.0% of grade Ⅳ GBMs and in 33% of grade Ⅲ AAs. Four cases harbored missense mutations in the EGFR kinase domain (L747A, S768I, V774M, and T790M). A total of 25% of the GBMs showed EGFR amplification. Moreover, 27% of the EGFR mutations occurred in the kinase domain. EGFRvⅢ positivity was detected in 8.0% of EGFR-amplified GBMs. We identified two other EGFR variants in GBM cases with deletions of exons 6–7 (Δe 6-7) (one case) and exons 2–14 (Δe 2-14) (two cases). Interestingly, in one case, the initial EGFRvIII mutation transformed into an EGFR Δe 2-14 mutation during recurrence. The frequency of EGFR alterations in our cohort was lower but the frequency of EGFR mutations in the kinase domain in our cohort was higher than that in The Cancer Genome Atlas and Memorial Sloan Kettering Cancer Center cohorts. Conclusions: We suggested that the EGFR gene profiles of GBM differ among cohorts and identified rare EGFR variants with longitudinal and temporal transformations of EGFRvⅢ.
Surgical Versus Non-Surgical Treatment of Humeral Shaft Fractures Compared By a Patient Reported Outcome: The Scandinavian Humeral Diaphyseal Fracture Trial (SHAFT) - A Study Protocol For a Pragmatic Randomized Clinical Trial
Authors: Karimi Dennis , Brorson Stig , Midtgaard Kaare S. , Fjalestad Tore , Paulsen Aksel , Olerud Per , Ekholm Carl , Wolf Olof , Viberg Bjarke 
Published: December 2021

Abstract
Background: The outcome of non-surgical treatment is generally good, but the treatment course can be long and painful with approximately a quarter of the patients acquiring a nonunion. Both surgical and non-surgical treatment can have disabling consequences such as nerve injury, infection and nonunion. The purpose of the study is to compare patient reported outcome after surgical and non-surgical treatment for humeral shaft fractures. Methods: A pragmatic randomized controlled trial is planned with two study groups (SHAFT-Y and SHAFT-E). A total of 287 eligible acute humeral shaft fractures are scheduled to be recruited and randomly allocated to surgical or non-surgical treatment with the option of early crossover due to delayed union. The surgical method within the allocation is decided by the surgeon. The primary outcome is the Disability of Arm, Shoulder and Hand (DASH) score at 52 weeks, and is assessor blinded. The secondary outcomes are DASH score, EQ-5D-5L, pain assessed by visual analogue score, Constant-Murley score including elbow range of motion and anchor-questions collected at all timepoints throughout the trial. All complications will be reported including; infection, nerve or vascular injury, surgical revisions (implant malpositioning, hardware failure, aseptic loosening and peri-implant fracture), major adverse cardiovascular events, and mortality. Patients declining randomization will be asked to enroll into an observational cohort with same outcomes and post-treatment regimes. Discussion: SHAFT will provide information on the effectiveness of two standard treatments for humeral shaft fractures, while taking the dilemmas within the population into account. Trial registration: Clinicaltrials.gov, NCT04574336. Registered on 5 October 2020.
PELA DESCOLONIZAÇÃO DO TEATRO-EDUCAÇÃO: APRENDER A APRENDER COM OS POVOS ORIGINÁRIOS DA AMÉRICA LATINA
Authors: Almeida Lígia Marina de 
Published: December 2021

Este artigo busca compartilhar a pesquisa de doutorado que desenvolvo atualmente, que, enquanto conteúdo pretende continuar minha pesquisa, iniciada no mestrado (e muito antes dele) em relação a imagens da luta dos povos originários do Brasil, que envolvem algum tipo de representação, contra os processos colonizatórios, em curso há mais de 500 anos, que prevêm sua (nossa) total extinção. Para dar conta de tal conteúdo de pesquisa, é necessário uma certa revisão da forma de fazê-la. Se aprendemos com Hegel (via Peter Szondi) que forma nada mais é que um “conteúdo enformado” pesquisaremos também, então, uma forma de pesquisa e compartilhamento público da mesma que vá de contra a esses mesmos processos colonizadores. Assim, proponho outras formas de apresentação do material a ser pesquisado, uma espécie de “anti-tese” já que, em minha pesquisa de mestrado, notei que a forma “escrita acadêmica” está historicamente intimamente ligada com os violentos processos coloniais, a saber: um pequeno livro de imagens luta dos povos originários compreendida entre 2013-2018, inspirado no modelo de ação proposto por Bertolt Brecht em seu livro ABC da guerra; um documentário com o ponto-de-vista sobre o corpo, o simbólico, a luta das lideranças dos povos originários do Brasil que aparecem nas imagens que coletei no mestrado e que formarão o ABC da luta dos povos originários; confecção e publicação de textos em periódicos na área das artes cênicas; perfo-palestras apresentadas por mim durante o processo e também um processo artístico-pedagógico baseado nesses materiais, em escolas estaduais indígenas aonde os riscos de aniquilamento desses povos originários são altos e também junto a não-indígenas, principalmente estudantes de cursos de Artes Cênicas no Brasil. Parte da “anti-tese” também se dá com a criação de estratégias de fortalecimento financeiro da luta dos povos originários com a utilização da arte para tal fim.
LA IDENTIDAD
Authors: Díaz Dalannais Javier 
Published: December 2021

Através de uma revisão sobre diferentes aproximaçoes ao conceito de identidade, abrimos a possibilidade de perguntarnos sobre: quais seriam nossas vantagens e desvantagens em tê-la? E se entendemos o conceito, identificação, como algo mais dinâmico, processual e transitório, talvez nos seria mais amável, inclusivo, menos doloroso e determinante para todos, o nosso próprio ser. No texto a seguir apresento a ideia sobre a caduquez e crise da identidade versus a dinâmica da identificação como processos do ser. Por um lado o estanco, rígido e quebradizo que é nos referenciarmos como alguém que É, e por outro lado, totalmente vertiginoso, incerto porém flexivel e flúido, com total possibilidade e potência de devir em outros e outros diversos SER. Ser um que é trânsito, que consegue dialogar através de linguagens que se constroem com o ser mesmo, e que não está prisioneiro nem é presa fácil para um sistema que precisa de estacas para fazer cercas ao mesmo homem.
Recent Advances in the Local Drug Delivery Systems for Improvement of
Anticancer Therapy
Authors: Arora Saroj , Singh Davinder , Kaur Prabhjot , Attri Shivani , Singh Sharabjit , Sharma Palvi , Mohana Pallavi , Kaur Kirandeep , Kaur Harneetpal , Singh Gurdeep , Rashid Farhana , Singh Dilpreet , Kumar Avinash , Rajput Ankita , Bedi Neena , Singh Balbir , Buttar Harpal Singh 
Published: December 2021

:
The conventional anticancer chemotherapies not only cause serious toxic effects but also
produce resistance in tumor cells exposed to long-term therapy. Usually, the selective killing of metastasized
cancer cells requires long-term therapy with higher drug doses because the cancer cells develop
resistance due to the induction of poly-glycoproteins (P-gps) that act as a transmembrane efflux pump to
transport drugs out of the cells. During the last few decades, scientists have been exploring new anticancer
drug delivery systems such as microencapsulation, hydrogels, and nanotubes to improve bioavailability,
reduce drug-dose requirement, decrease multiple drug resistance, and save normal cells as
non-specific targets. Hopefully, the development of novel drug delivery vehicles (nanotubes, liposomes,
supramolecules, hydrogels, and micelles) will assist in delivering drug molecules at the specific target
site and reduce undesirable side effects of anticancer therapies in humans. Nanoparticles and lipid formulations
are also designed to deliver a small drug payload at the desired tumor cell sites for their anticancer
actions. This review will focus on the recent advances in drug delivery systems and their application
in treating different cancer types in humans.
Conceptions About Health and Care Practices of Black Men from a Quilombola Community
Authors: de Sousa Anderson Reis , da Silva Santana Thiago , Caldas Santos Heron Silva , Escobar Oscar Javier Vergara , Daza Angélica Isabel Romero , de Santana Carvalho Evanilda Souza , de Andrade Nhamuave Edson , de Camargo Climene 
Published: December 2021

Introduction:Universal health coverage will be guaranteed to all individuals, safeguarding the rights of traditional communities, as in the quilombola population, respecting the dimensions of interculturality, gender and ethnicity.Objective:The aim of this study is to describe the conceptions of health and health care practices of Afro-Brazilian men from a quilombola community.Methods:This was a qualitative descriptive study conducted with Afro-Brazilian men from a quilombola community in Bahia, Brazil, where there is a significant concentration of black people and quilombola communities.Results:This group’s conceptions of health are based on the combination of the individual body with the body that is socially and culturally situated in the community. Health care practices are anchored in cultural knowledge and strengthened by the bonds with nature, friends and religious leaders.Conclusion:The black men from quilombola communities are in a state of vulnerability due to the lack of access to health services.
Bibliometric Analysis Of Research on Coronavirus Infection and Patient Safety in Health Care
Authors: Nascimento Glícia Cardoso , Santos Gabriela Martins , Moura Samuel Ricardo Batista , de Carvalho Ana Raquel Batista , da Silva Andrade Letícia , Moura Luana Kelle Batista , Mendes Felismina , Moreira Maria Adelaide Silva Paredes , Moura Maria Eliete Batista 
Published: December 2021

Objective:
The study aimed at analyzing the international scientific publications on coronavirus infection and patient safety in health care.

Methods:
This research is a bibliometric study carried out by searching published articles in theISIWebofKnowledge/WebofScience database and analyzing the results through bibliometric analysis software HistCite. The selected time frame was between 1970 and 2020, and we used the following descriptors: “coronavirus infection” OR “severe acute respiratory syndrome” OR “COVID-19/SARS-CoV-2”.

Results: We found 5,434 publications in 1,491 different journals; they are written by 18,274 authors linked to 4,064 institutions, which are located in 104 countries. In the citations analysis, the h-index was 155, and the average of citations each article received was 30.79.

Conclusion:
During the studied period, the Web of Science database showed two peaks of publications on coronavirus infections.The first comprised 768 articles published between 2003 and 2004 when a new coronavirus caused an outbreak of severe acute respiratory failure. The second consisted of 576 articles published between 2019 and 2020, during the period of the COVID-19 pandemic COVID-19. The knowledge on coronavirus infection should be widely shared so that new studies can be designed and the world scientific community can contribute to improving patient safety in healthcare and preventing new pandemics of severe acute respiratory infection caused by coronaviruses.
Physical Disabilities and Individual Vulnerability: Perspectives in Hyperendemic Municipalities for Leprosy
Authors: Almeida Priscilla Dantas , de Araújo Telma Maria Evangelista , Ramos Júnior Alberto Novaes , de Araújo Olívia Dias , Fronteira Inês , Neri Érica de Alencar Rodrigues , Cardoso Jonas Alves , Costa Joelma Maria 
Published: December 2021

Introduction:Epidemiological, operational and socio-demographic data on leprosy, as well as its direct and indirect impact on the affected person, his/her family, and community, are included in the group of neglected diseases.Objective:To analyze the association between the occurrence of physical disabilities in leprosy cases and individual vulnerability in hyperendemic municipalities.Methodology:population-based cross-sectional study of leprosy cases reported from 2001 to 2014 in two municipalities of Piauí/Brazil. Interviews and descriptive, bivariate and multivariate analyses were conducted to study eventual associations.Results:Of the 603 cases evaluated, the most frequent were female (52%), brown (46%), with low schooling, married/united (50%) and retired (28%). A significant proportion of cases was multibacillary (46%), Virchowian clinical form (14%), reactional episodes (20%), disability degree I or II (70%). The explanatory variables for the presence of some degree of physical disability were gender, age group, perceived health, operational classification, clinical form, and hypertension (p<0.05).Conclusion:The physical disabilities caused by leprosy involve, in addition to dermatoneurological damage, psychological damage resulting from the strong stigma they produce. This result reinforces the need for differentiated care and nursing in disability prevention, physical rehabilitation and psychological follow-up to ensure comprehensive care.
Using Momentary Assessment and Machine Learning to Identify Barriers to Self-management in Type 1 Diabetes: Observational Study
Authors: Zhang Peng , Fonnesbeck Christopher , Schmidt Douglas C , White Jules , Kleinberg Samantha , Mulvaney Shelagh A 
Published: December 2021

Background
For adolescents living with type 1 diabetes (T1D), completion of multiple daily self-management tasks, such as monitoring blood glucose and administering insulin, can be challenging because of psychosocial and contextual barriers. These barriers are hard to assess accurately and specifically by using traditional retrospective recall. Ecological momentary assessment (EMA) uses mobile technologies to assess the contexts, subjective experiences, and psychosocial processes that surround self-management decision-making in daily life. However, the rich data generated via EMA have not been frequently examined in T1D or integrated with machine learning analytic approaches.

Objective
The goal of this study is to develop a machine learning algorithm to predict the risk of missed self-management in young adults with T1D. To achieve this goal, we train and compare a number of machine learning models through a learned filtering architecture to explore the extent to which EMA data were associated with the completion of two self-management behaviors: mealtime self-monitoring of blood glucose (SMBG) and insulin administration.

Methods
We analyzed data from a randomized controlled pilot study using machine learning–based filtering architecture to investigate whether novel information related to contextual, psychosocial, and time-related factors (ie, time of day) relate to self-management. We combined EMA-collected contextual and insulin variables via the MyDay mobile app with Bluetooth blood glucose data to construct machine learning classifiers that predicted the 2 self-management behaviors of interest.

Results
With 1231 day-level SMBG frequency counts for 45 participants, demographic variables and time-related variables were able to predict whether daily SMBG was below the clinical threshold of 4 times a day. Using the 1869 data points derived from app-based EMA data of 31 participants, our learned filtering architecture method was able to infer nonadherence events with high accuracy and precision. Although the recall score is low, there is high confidence that the nonadherence events identified by the model are truly nonadherent.

Conclusions
Combining EMA data with machine learning methods showed promise in the relationship with risk for nonadherence. The next steps include collecting larger data sets that would more effectively power a classifier that can be deployed to infer individual behavior. Improvements in individual self-management insights, behavioral risk predictions, enhanced clinical decision-making, and just-in-time patient support in diabetes could result from this type of approach.
Thematic Analysis on User Reviews for Depression and Anxiety Chatbot Apps: Machine Learning Approach
Authors: Ahmed Arfan , Aziz Sarah , Khalifa Mohamed , Shah Uzair , Hassan Asma , Abd-Alrazaq Alaa , Househ Mowafa 
Published: December 2021

Background
Anxiety and depression are among the most commonly prevalent mental health disorders worldwide. Chatbot apps can play an important role in relieving anxiety and depression. Users’ reviews of chatbot apps are considered an important source of data for exploring users’ opinions and satisfaction.

Objective
This study aims to explore users’ opinions, satisfaction, and attitudes toward anxiety and depression chatbot apps by conducting a thematic analysis of users’ reviews of 11 anxiety and depression chatbot apps collected from the Google Play Store and Apple App Store. In addition, we propose a workflow to provide a methodological approach for future analysis of app review comments.

Methods
We analyzed 205,581 user review comments from chatbots designed for users with anxiety and depression symptoms. Using scraper tools and Google Play Scraper and App Store Scraper Python libraries, we extracted the text and metadata. The reviews were divided into positive and negative meta-themes based on users’ rating per review. We analyzed the reviews using word frequencies of bigrams and words in pairs. A topic modeling technique, latent Dirichlet allocation, was applied to identify topics in the reviews and analyzed to detect themes and subthemes.

Results
Thematic analysis was conducted on 5 topics for each sentimental set. Reviews were categorized as positive or negative. For positive reviews, the main themes were confidence and affirmation building, adequate analysis, and consultation, caring as a friend, and ease of use. For negative reviews, the results revealed the following themes: usability issues, update issues, privacy, and noncreative conversations.

Conclusions
Using a machine learning approach, we were able to analyze ≥200,000 comments and categorize them into themes, allowing us to observe users’ expectations effectively despite some negative factors. A methodological workflow is provided for the future analysis of review comments.
Nghiên cứu ứng dụng hệ thống nuôi cấy ngập chìm tạm thời trong nhân giống in vitro cây hoa lily (Lilium spp.)
Authors: Phạm Thị Thùy Trang 
Published: December 2021

Lily (Lilium spp.) là cây hoa quan trọng, có giá trị kinh tế cao, được trồng ở nhiều nước trên thế giới. Tuy nhiên, giống hoa lily sản xuất ở Việt Nam chưa đủ đáp ứng nhu cầu trong nước, đa số giống hoa được nhập khẩu từ nước ngoài. Trong nghiên cứu này, hoa lily được nhân giống in vitro thành công trên hệ thống ngập chìm tạm thời, sử dụng vật liệu ban đầu là mẫu vảy củ. Vật liệu được khử trùng trong 9 phút bằng dung dịch HgCl2 1‰. Vật liệu sạch nấm khuẩn được nuôi cấy trên hệ thống ngập chìm chứa môi trường MS có bổ sung đường 30 g/L BA 2 mg/L, NAA 0,5 mg/L. Khả năng tái sinh chồi cao nhất 83,89%. Kết quả nghiên cứu cho thấy số củ mới được tạo thành trên một mẫu là cao nhất (3,72 củ), thời gian ngập chìm 5 phút với chu kỳ ngập 6 giờ. Số rễ hình thành trên một mẫu là cao nhất (4,52 rễ), thời gian ngập chìm 3 phút với chu kỳ ngập 6 giờ. Kết quả cho thấy hoa lily sinh trưởng và phát triển tốt trên hệ thống ngập chìm tạm thời.