bluuebunny/crossref_metadata_2025_split huggingface dataset:
Possibilities of correction of post viral other dysfunction in the application of COVID-19
Authors: Vladimirova T. Yu. , Baryshevskaya L. A. , Kurenkov A. V. 
Published: December 2021

Introduction. One of the characteristic manifestations of COVID-19 is a disorder of smell, which, according to the literature, occurs in 61.2% - 85.6% of patients with COVID-19. The article discusses the problems of post-viral dysosmia in COVID-19 convalescents. Purpose of the study. Evaluation of olfactory disorders in patients after coronavirus infection and the possibility of obtaining additional benefits from prescribing bioregulatory medicine drugs.Materials and methods. The assessment of the severity of olfactory disorders in patients, taking into account the age according to self-assessment data using a visual analogue scale, as well as an objective assessment of odor identification using the Sniffin ‘Sticks Screening 12 Test. The possibility of increasing the efficiency of recovery of olfactory disorders by prescribing complex preparations of bioregulatory therapy (main group) was studied.Results. The percentage of persons who fully restored the olfactory function in the main group was 56.5%, while in the patients of the control group only in 6.6%. Faster (on the 7th day) dynamics of identification testing using SST-12 in patients taking complex preparations of bioregulation therapy was noted. On the 3rd day of therapy, there was a significant decrease in anxiety in patients treated with bioregulatory drugs.Discussion. The conducted study objectively confirmed that the olfactory disorder is present in the vast majority of patients with ARS. The appointment of bioregulatory therapy contributes to the early restoration of the olfactory function.Conclusions. Based on the results of this study, it can be concluded that it is advisable to use bioregulatory drugs.
Efficacy of azoximer bromide in the treatment of hospitalized patients with moderate to severe community-acquired pneumonia
Authors: Zyryanov S. K. , Butranova O. I. , Ershov A. V. , Manasova Z. Sh. 
Published: December 2021

Introduction. The high incidence of community-acquired pneumonia and the high complication rates in the cases of severe pneumonia actualize the search for new pharmacotherapy tools to improve the effectiveness of standard patient management regimens. A high level of severe inflammatory response underlies the high risk for developing septic complications of pneumonia, along with impaired immune responses.The aimis to evaluate the efficacy of azoximer bromide introduction in the combination therapy regimen for hospitalized patients with moderate to severe community-acquired pneumonia.Materials and methods. A prospective, open label, parallel group, randomized study comparing the efficacy of azoximer bromide introduction in the combination therapy of hospitalized patients with moderate to severe community-acquired pneumonia was conducted at the premises of Federal Scientific and Clinical Center for Reanimatology and Rehabilitation. 30 patients were included in the study group and 37 patients in the comparator group. The baseline characteristics were comparable in both groups. Results. The azoximer bromide introduction in the combination therapy of patients with community-acquired pneumonia led to a statistically significant reduction in the duration of hospital stay (Me (LQ; HQ): 9 (8; 10) days for the study group and 13 (10; 14) days for the comparator group, (p = 0.000078), duration of ICU stay (Me (LQ; HQ) 2 days (1.5; 2.5) and 5 days (5.0; 6.0), respectively, (p = 0.00001), the duration of febrile fever 5 (± 0.6) days versus 10 (± 1.2) days (p = 0.0000), the incidence of acute respiratory failure (13.33% in group 1 versus 37.84% in group 2, p = 0.024) and septic shock (10% in group 1 versus 32.43% in group 2, p = 0.0285).Conclusions. The azoximer bromide introduction in the standard therapy regimen for patients with community-acquired pneumonia allowed to reduce the duration of hospital stay, the duration of ICU stay, the length of febrile fever, the incidence of septic shock and respiratory failure. The possible mechanisms of action may include a reduction of the severe inflammatory reactions and an optimization of the patient's immune response to the infectious process.
Features of the use of topical preparations of framycetin sulfate in the treatment of rhinosinusitis
Authors: Eremin S. A. , Dyakov I. M. , Pavlova S. S. 
Published: December 2021

Introduction. Acute rhinosinusitis is one of the most common infectious diseases in the world. But despite their predominantly viral nature, the activation of their own microflora occurring during the disease, the addition of pathogenic and the associated risks of rhinogenic complications lead to the widespread use of antibacterial therapy for this pathology. Local antiseptics, such as framycetin sulfate in the form of nasal spray, play an important role in the multicomponent structure of rhinosinusitis therapy.The aim of the studywas to evaluate the effect of an aerosol preparation of framycetin sulfate of domestic and imported production on the activity of the atrial fibrillation of the nasal cavity as topical antibacterial therapy in acute rhinosinusitis.Materials and methods. The study included 30 adult patients diagnosed with acute rhinosinusitis. The patients were randomized into 2 equal groups and received standard therapy for this disease, according to clinical recommendations. The differences in the groups concerned only topical antibacterial therapy. The 1st experimental group used a drug of domestic production, the 2nd group - a control group, used an imported framycetin spray.Results. Data were obtained not only comparing the clinical picture depending on the treatment, but also information about the effect of the drug on the activity of the atrial epithelium of the nasal cavity, the distribution of the substance in the nasal cavity, and even considered the structural differences of the vials that affect the distribution of the drug during injection. Conclusion. Topical antibacterial therapy with framycetin sulphate is an effective method in complex treatment of acute rhinosinusitis. Innovative technologies for the creation of an aerosol of framicetin solution allow to achieve stable dosage of the drug during use.
Systemic antibiotic therapy of patients with acute bacterial sinusitis taking into account resistance
Authors: Starostina S. V. , Sivokhin D. A. 
Published: December 2021

Acute rhinosinusitis is one of the most common diseases in the world. According to statistics, about 10 million cases are registered in Russia every year.Acute bacterial rhinosinusitis (ABRS) in most cases develops as a result of an acute respiratory viral disease, proceeds easily and it does not require antibiotic therapy. However, it significantly reduces the patient's quality of life in cases of moderate and severe disease, and in the absence of timely treatment, can lead to intracranial complications (meningitis, encephalitis, intracranial abscesses, etc.) and orbital (reactive edema of the eyelid, phlegmon of the orbit, periorbital abscesses, etc.). To avoid complications, with exacerbation of rhinosinusitis, it is necessary to choose the right antibiotic therapy, taking into account the resistance of the microorganisms that caused the disease.The article describes the differential diagnosticprinciples of bacterial rhinosinusitis according to the latest recommendations and research in this area, the most common antibiotic-resistant pathogens in the practice of an ENT doctor are presented, the issue of choosing the correct systemic antibiotic therapy for the treatment of patients with moderate and severe acute bacterial rhinosinusitis is considered according to modern data on the sensitivity of bacterial pathogens to antibacterial drugs prescribed in the otorhinolaryngologist's practice. The article presents data on a new universal cephalosporin of the 3rd generation (the active ingredient is cefditoren), as a second- and third-line drug, due to its high activity against most causative agents of acute bacterial rhinosinusitis, and clinical observation using the above antibacterial agent within the framework of the considered topics.
Rhinological tactics in the complex treatment of patients with severe combined cranio-facial trauma who are on mechanical ventilation
Authors: Dvorianchikov V. V. , Yanov Yu. K. , Nakatis Ya. A. , Isachenko V. S. , Ilyasov D. M. , Gofman V. R. , Vinichenko K. V. 
Published: December 2021

Introduction. In recent years, injuries ranked fourth among the main causes of death of the population after diseases of the cardiovascular system, malignant neoplasms and infectious diseases. The clinical course of associated injuries, as a rule, is characterized by a high number of complications, much more than in isolated injuries.Objective. Explore approaches to improving otorynolaryngological tactics from the standpoint of normalizing the functional state of the nasal mucosa, as well as increasing the effectiveness of treatment of patients with severe concomitant trauma on prolonged mechanical ventilation.Materials and methods. In the process of studying the problem of impaired mucociliary clearance of the nasal mucosa, the functional state of the mucous membrane in patients with severe concomitant head trauma undergoing prolonged artificial lung ventilation was analyzed. We studied the state of one of the most important mechanisms of sanitation and local protection of the respiratory tract - mucociliary clearance, which provides the necessary potential for barrier, cleansing and immune functions. A study was made of the thermal effect of the nasal cavity, pH + of the mucous membrane, the study of the frequency of beating of the cilia of the ciliated epithelium and the rate of mucociliary transportResults and discussion. The results of the study showed that the problem of post-traumatic and nosocomial sinusitis in patients with severe concomitant head trauma must be resolved as soon as possible, with the involvement of modern diagnostic and treatment methods, including the proposed method of artificial ventilation of the nose. The severity of the patient's condition, the severity of the injuries received excludes the use of advanced methods of surgical, otorhinolaryngological treatment.Conclusion. 12:30 PMThe use of minimally invasive methods of treatment, precision technical execution, including under endovideo control, polysinusotomy made it possible not to burden the condition of the victims and exclude iatrogenic damage that could entail irreversible changes in the body and condition of the victim.
General practitioner management for chronic sensorineural hearing loss in older adults
Authors: Vladimirova T. Yu. , Martynova A. B. 
Published: December 2021

Introduction. The article is devoted to the special role of the primary care physician - therapist, geriatrician, general practitioner, in assisting the elderly and senile in taking appropriate and timely measures in identifying people with chronic sensorineural hearing loss (SNL), consulting them at the stage of primary health care.Aim of the study. Understand the intended role of general practitioners and therapist in identifying and counseling patients with hearing loss in primary health care.Materials and methods. A survey of general practitioners and therapist was conducted in the form of 88 statements, collected in six concepts, in response to the question “What should be the role of a general practitioner in the treatment of chronic sensorineural hearing loss in persons of an older age group?” in the format of a Google-questionnaire.Results. The results showed a sufficient awareness of general practitioners and therapist about the predisposition of their elderly patients to hearing loss and the significance of the associated consequences on the quality of life. As a result of the data obtained, the highest percentage of statements was noted in Concept 1 “Determine - Diagnose - Discuss” and varied on individual issues from 27.8% to 55.6%, the lowest - in Concept 5 “Educate - Strategise - Encourage” and ranged from 16.7% to 44.4%.Discussion. Strengthening collaboration between therapists and otorhinolaryngologists, otorhinolaryngologists, and audiologists is the most effective strategy for reducing individuals with untreated SNL. The importance of the role of the primary care physician in multidisciplinary care and its coordination is especially emphasized in the concept of “Know - Refer - Coordinate”.Conclusions. The authors conclude that the priority concept of modern health care, which makes it possible to significantly improve the quality of life of patients in the older age group and reduce the psychosocial consequences of hearing loss.
The validity of topical drug therapy for otitis media with effusion
Authors: Morozova S. V. , Eremeeva K. V. , Suaifan W. H.A. 
Published: December 2021

Otitis media with effusion is difficult to diagnose, since the course of the disease is mostly asymptomatic, while the initial stage of the disease is very similar to Eustachiitis or the pre-perforative stage of acute otitis media. At this stage, dysfunction of the auditory tube and negative pressure in the tympanic cavity creates the conditions for the production of transudate, which clinically, in addition to hearing loss, is accompanied by soreness, a feeling of congestion, pressure, fluid transfusion in the ear. When conducting local medical procedures, they are primarily guided by the condition of the mucous membrane of the eustachian tube, nasopharynx and nasal cavity, but changes in the eardrum are no less important. Thus, the use of topical analgesics with an anti-inflammatory effect becomes no less relevant in the treatment.A literature review was carried out with an analysis of scientific research data on the use of a topical combination drug that has a local anesthetic and anti-inflammatory effect in the treatment of diseases of the external and middle ear.Analysis of the literature showed that the use of lidocaine-phenazone-containing drops promotes rapid regression of the inflammation in the external auditory canal and the tympanic membrane, as well as relieving of pain. It can be used both in children (including newborns) and in adults who are suffering from otitis media but with intact tympanic membrane, including otitis media with effusion.Combined topical drugs containing lidocaine-phenazone demonstrate efficacy and safety in the treatment of catarrhal and otitis media with effusion in all age groups.
AVALIAÇÃO DA SATISFAÇÃO DO USUÁRIO COM O ACOLHIMENTO NA ESTRATÉGIA DA SAÚDE DA FAMÍLIA NO RECIFE (PE)
Authors: Lucena Ligiana Nascimento , Melo Ricardo Henrique Vieira , Rodrigues Maísa Paulino , Andrade Fábia Barbosa de , Vilar Rosana Lúcia Alves , Bosco Filho João 
Published: December 2021

Introdução: o acolhimento na Atenção Básica de Saúde requer atitudes que garantam uma escuta qualificada e o estabelecimento de vínculos com vistas à resolubilidade dos problemas de saúde dos usuários. Objetivo: este estudo teve por objetivo avaliar a satisfação dos usuários acerca do acolhimento na Estratégia Saúde da Família (ESF) em Recife, Pernambuco. Métodos: trata-se de um estudo quantitativo e seccional. Os sujeitos foram 297 usuários da ESF nos seis distritos sanitários do município. A coleta dos dados ocorreu através de entrevistas individuais e aplicação de uma escala de satisfação do usuário, intitulada SATIS-BR, já validada. A análise do material se deu com o auxilio do software SPSS 17.0. Resultados: Os achados apontaram que a maioria dos usuários está satisfeita com o acolhimento ofertado pelos profissionais de saúde. Nessa direção, 66% afirmaram ser escutados pelas equipes da ESF; 80,2% obtiveram ajuda quando procuraram o acolhimento; 64,6% disseram que a acolhida foi amigável ou muito amigável. Contudo, demonstraram insatisfação com a infraestrutura das Unidades de Saúde, apontando sugestões de melhorias. Conclusão: a pesquisa demonstrou que ocorreram melhorias a partir da implantação do Projeto ‘Recife em Defesa da Vida’, facilitando o acesso às ações de saúde, catalisada por um acolhimento promotor de escuta qualificada e de vínculos solidários.
OS IDENTIFICAÇÃO DE DEMANDAS DE PROJETO EM APARTAMENTO PARA USUÁRIOS IDOSOS POR MEIO DE MODELOS FÍSICOS
Authors: Rodrigues Rodrigo , Imai César 
Published: December 2021

O crescimento da população idosa no Brasil desperta a necessidade do avanço em estudos sobre o meio espacial, principalmente, a habitação. Com o intenso processo de verticalização nas cidades brasileiras, entende-se que é importante aferir a produção contemporânea de apartamentos e extrair dela elementos que possam alimentar projetos futuros. Portanto, este artigo tem como objetivo verificar a viabilidade do uso de modelos tridimensionais físicos como protótipos de simulação de ambientes habitacionais para identificar os principais requisitos em relação às novas necessidades, desses usuários. O protótipo utilizado foi desenvolvido a partir do uso de cortadoras a laser e impressora 3D, e possui uma escala maior do que a comumente utilizada em representações e certa flexibilidade, que permite fazer alterações de projeto de forma rápida junto ao usuário em um processo participativo. Para auxiliar na coleta de informações foi elaborado um protocolo de procedimentos de aplicação da simulação, com uma entrevista que buscou informações sobre a opinião dos usuários durante o processo e um questionário ao final do mesmo. Os dados coletados permitiram identificar que levar o usuário a simular algo que nunca imaginou, traz-lhe a possibilidade de refletir e avaliar questões, ampliando os seus conhecimentos e permitindo refletir sobre aspectos que poderiam acarretar problemas no uso do apartamento. A identificação de semelhanças do modelo com ambientes reais incentivou a interação do usuário com o protótipo, permitindo, assim, extrair algumas informações mais detalhadas que outras ferramentas usadas de forma isolada, como as entrevistas e questionários, por exemplo, não são capazes de captar.
Implementation of the Flexible Assertive Community Treatment (FACT) Model in Norway: eHealth Assessment Study
Authors: Bønes Erlend , Granja Conceição , Solvoll Terje 
Published: November 2021

Background
Flexible Assertive Community Treatment (FACT) is a model for treatment of long-term severe mental disorders. This method has become more widespread in Norway.

Objective
The objective of our study was to examine how the implementation of FACT teams in Norway has been affected by eHealth policy, infrastructure, and regulations. Another objective was to examine existing literature on eHealth interventions and challenges within FACT teams.

Methods
We have examined Norwegian policy regulating mental health services, laws and regulations, eHealth infrastructure, relevant literature on FACT teams, and current implementation of FACT in Norway.

Results
FACT teams are a wanted part of the Norwegian service system, but the current eHealth infrastructure makes sharing of data within teams and levels of health care challenging, even if eHealth regulations allow such sharing. This has been shown to be an issue in the current implementation of FACT teams in Norway. There is little or no existing research on the eHealth challenges facing FACT teams.

Conclusions
Weaknesses in the Norwegian eHealth infrastructure have been a barrier for an easy implementation of FACT teams in Norway. It is difficult to share information between the different levels of health care. We need systems that allow for easy, secure sharing of health information to and between the FACT team members and other involved health care workers.
Hearing Loss in Patients With Morquio Syndrome: Protocol for a Scoping Review
Authors: Diaz-Ordoñez Lorena , Candelo Estephania , Silva-Cuero Katherine , Saldarriaga Wilmar , Murgašová Lenka , Magner Martin , Pachajoa Harry 
Published: November 2021

Background
Mild to moderate hearing loss is common in patients with mucopolysaccharidosis (MPS) IVA. The hearing loss can be conductive, sensorineural, or mixed. However, in these patients, the mixed form is frequent, attributed to the combination of conductive and neurosensory elements, with slowly progressive evolution. Conductive hearing loss may be secondary to recurrent upper respiratory tract infections, serous otitis media, and deformities of the ear ossicles due to the accumulation of glycosaminoglycans (GAGs). Meanwhile, the sensorineural form is mainly attributed to the accumulation of GAGs in the auditory system.

Objective
The aim of this scoping review is to understand the extent and type of evidence in relation to the physiopathology, classification, epidemiology, and clinical management of hearing loss and the effect of therapy for hearing loss in patients with MPS IVA.

Methods
This scoping review includes participants across all genders and of no particular age group who are diagnosed with MPS IVA and develop hearing loss as a comorbidity. No exclusion criteria (country, language, or document type) will be applicable. The information sources will include experimental and quasi-experimental, analytical observational, observational, and qualitative studies. Unpublished literature will not be covered. Grey literature will be covered. A total of 2 independent reviewers will participate in the process of screening the literature, paper selection, and data extraction, and this process will be performed blindly. When all manuscripts have been selected, disagreements that arise between the 2 reviewers at each stage of the selection process will be resolved through discussion or with an additional reviewer. Results will be reported with descriptive statistics and information will be displayed in a diagrammatic or tabular manner, as explained in the JBI guidelines.

Results
The literature search was performed in November 2021 in MEDLINE, LILACS (Literatura Latino-Americana e do Caribe em Ciências da Saúde), the Cochrane Library, ScienceDirect, Google Scholar, and OpenGrey; a total of 780 results were retrieved. Completion of the review is expected in mid-2022.

Conclusions
This scoping review will be the first to describe the extent of the information regarding the development of hearing loss in the MPS IVA population. The data gathered by this review may lead to an understanding of the grade of hearing loss in this population and allow for the assessment of possible interventions according to the disease pattern.

International Registered Report Identifier (IRRID)
PRR1-10.2196/32986