bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Sheath Type on Vascular and Bleeding Complications After Transcatheter Aortic Valve Replacement: A Post Hoc Analysis From the MARVEL Registry Study
Authors: Pan Emily , Kroon Herbert G. , Tonino Pim A. L. , Amoroso Giovanni , Laine Mika , Christiansen Evald H. , Toggweiler Stefan , Ten Berg Jur , Malmberg Markus , Slagboom Ton , Moriyama Noriaki , Terkelsen Christian J. , Moccetti Federico , Gheorghe Livia , Bigelow Darra , Webb John , Wood David , Van Mieghem Nicholas , Savontaus Mikko 
Published: January 2025

ABSTRACTBackgroundVascular and bleeding complications remain a concern after transfemoral transcatheter aortic valve replacement (TAVR). The impact of the sheath type on these complications remains unclear.MethodsThe prospective MARVEL registry study analyzed enrolled 500 patients undergoing large‐bore transfemoral procedures and arteriotomy closure with the MANTA vascular closure device from 10 hospitals in Europe and Canada. We stratified these patients according to type of sheath used (expandable or conventional). A propensity‐matched analysis was performed using VARC‐2 major or minor vascular and bleeding complications as the primary endpoint. The secondary endpoint was time to hemostasis.ResultsWe identified 196 propensity‐matched pairs. Major vascular complications occurred in 3.6% in the expandable sheath group and 4.1% in the conventional sheath group (p = 1.0). Minor vascular complications occurred in 5.6% in the expandable sheath group and 4.6% in the conventional sheath group (p = 0.819). There were no significant differences in bleeding complications between groups. Time to hemostasis after MANTA closure was significantly shorter in the expandable sheath group (30 vs. 60 s, p < 0.001).ConclusionsA propensity‐matched analysis demonstrated no significant differences in vascular complication rates with MANTA arteriotomy closure after removal of large bore expandable or conventional sheaths. Time to hemostasis was significantly shorter in the expandable sheath group.
Retinocochleocerebral Vasculopathy Presented as Bilateral Neovascular Glaucoma
Authors: Shariati Mehrdad Motamed , Shekarchian Farid , Yaghoubi Mariye 
Published: January 2025

ABSTRACTSusac is a rare systemic disease characterized by ischemic events involving the cochlea, brain, and retina. Delay in the diagnosis leads to sight‐threatening complications such as neovascular glaucoma.
Advancements in silicon‐air batteries: High performance asymmetric‐electrolyte and quasi‐solid‐state designs for portable applications
Authors: Pang Shengcui , Wang Junjie , Wang Baoling , Zhu Mingshan , Hu Guangzhi , Xie Haijiao , Hu Sujuan 
Published: January 2025

AbstractSilicon‐air batteries (SABs) hold significant potential as efficient energy conversion devices due to their high theoretical energy density, theoretical discharge voltage, and favorable energy‐to‐cost ratios. However, their applicability has been hindered by low output discharge potential, high discharge polarizations, and singular aqueous configuration. To address these, the catalyst with faster oxygen reduction reaction (ORR) kinetic rate, nitrogen‐doped carbon materials functionalized with FeMo metal clusters (FeMo‐NC), was designed in acid electrolyte and thus high output voltage and energy density SABs with asymmetric‐electrolytes have been developed. This innovative design aligns the reaction rates of the cathode and anode in SABs, achieving stable discharge around 1.7 V for 188 h. Furthermore, an all‐in‐one quasi‐solid‐state SAB (QSSSAB) was first developed using a suitable acid–base gel electrolyte. This all‐in‐one QSSSAB showcases good safety, low cost, and portability, with open‐circuit voltage of 1.6 V and energy density of 300.2 Wh kg−1, surpassing the energy density of most previously reported aqueous SABs. In terms of application, these compact all‐in‐one QSSSABs can provide stable and reliable power support for portable small electronic devices (such as electronic players, diodes, and electronic watches).
Impact of Structural Subtleties on Chirality Induction and Amplification in Trizinc(II)Porphyrin Trimers
Authors: Chandel Dolly , Pal Chandrani , Rath Sankar Prasad 
Published: January 2025

AbstractHerein, we report the precise control of molecular to supramolecular chirality induction at the single‐molecule level just upon subtle modification in an achiral ‘nano‐size’ trizinc(II) porphyrin trimer. A slight variation in the projection of the substituent at the periphery of the central porphyrin unit in a porphyrin trimer (host) resulted in pronounced changes in the interchromophoric arrangement, leading to distinct ‘open’ and ‘closed’ conformations. While ‘open’ form generates ‘monomeric’ complex with low CD amplitude, ‘closed’ form produces exclusive ‘polymer’ with large, amplified CD signal with opposite sign due to stronger intermolecular excitonic coupling. Also, the sign of the CD couplets is just opposite between R and S substrates for both polymer and monomer which suggest that the chirality is predominantly governed by the stereogenic projection of the chiral center. X‐ray structures of the host and polymer have been reported here. Crystallographic characterization offers a detailed perspective on the structural and geometrical transformations in the polymer, enabling a systematic understanding of its optical properties. DFT and TD‐DFT calculations strongly corroborate with the experimental findings.
A Fluorescent Probe Differentiates Apoptosis from Cysteine‐Deprivation Ferroptosis through Imaging of Viscosity and Lipid Droplets
Authors: Pareek Niharika , Yadav Rashmi , Munan Subrata , Baruah Mousumi , Samanta Animesh 
Published: January 2025

AbstractSince death is an inevitable phenomenon, exploring cell deaths holds importance. During this process, the cellular microenvironment within cells such as pH, polarity, viscosity etc alter. One such microenvironment, viscosity elevates during different cell deaths. However, demarcating cell death processes solely based on viscosity sensing is challenging. Herein, we develop a unique fluorescent probe PS‐NAP after careful investigation among three analogues for efficient viscosity imaging in HeLa cells. Cationic PS‐NAP, a MMP independent molecular probe, can potentially target mitochondria and map elevated mitochondrial viscosity during apoptosis, starvation and drug induced ferroptosis processes. Notably, during ferroptosis induced by cysteine deprivation, PS‐NAP exclusively colocalizes in newly generated lipid droplets (LDs) instead of mitochondria. Thus, the probe has a potential for demarcating cysteine deprivation‐induced ferroptosis from other cellular stresses such as apoptosis.
Gender equity in oncology: Progress, challenges, and the path forward in urologic oncology and oncologic specialties
Authors: Krischak Madison K. , Nam Catherine S. , Luckenbaugh Amy N. , Herrel Lindsey A. 
Published: January 2025

AbstractWomen now comprise over 50% of medical school graduates and over one‐third of practicing physicians in the United States. Despite this progress, significant barriers to career advancement and leadership persist, particularly in male‐dominated fields like urology and oncology. Women physicians are linked to improved patient outcomes and are critical to addressing the projected physician shortage, which is expected to be exaggerated in oncology specialties. This review highlights progress, challenges, and future directions for gender equity in urology, urologic oncology, and oncology subspecialties. Urology and urologic oncology have seen growth in female representation, whereas radiation oncology remains stagnant, and medical oncology has reached near gender parity among trainees. However, leadership roles across all these fields continue to reflect gender inequities. Key barriers include the gender pay gap, insufficient maternal leave policies, workplace harassment, and lack of mentorship and sponsorship for women physicians. Moving forward, efforts to advance gender equity must include transparent pay structures, supportive maternal leave, and robust antiharassment policies. Promoting women in leadership and fostering mentorship are also essential to retaining and advancing women in these fields. By addressing these issues, the health care community can progress toward gender equity, strengthen the physician workforce, and improve patient outcomes. Institutional and national advocacy is crucial for creating an equitable and effective medical community.
“Yes, This Is Still Circle”: Circle‐Keeping Online During COVID—An Interview with Kay Pranis and Becky McCammon
Authors: Strauss Jill 
Published: January 2025

ABSTRACTThis Practice Note is an interview with leading Circle‐keepers Kay Pranis and Becky McCammon about their experiences facilitating Talking Circles virtually during COVID. They describe their respective leaps into the unknown of online Circle to meet peoples' need for community at a time when we could not gather together in person and how they each managed during that time of uncertainty. The conversation was edited for length and clarity in which they discussed the needs of restorative justice practitioners and others for relational support and how they worked to meet the need. What they both learned is that while there were some challenges, there were also many unanticipated opportunities and benefits discovered in the process of adapting to virtual Circles. This retrospective interview documents how practitioners adapted quickly during a pandemic in response to the need to be in the community when we could not meet in person.
Exploring the link between corporate social responsibility and financial performance in social enterprises: The mediating role of productivity
Authors: Wejesiri Mahinda , Park Chansoo , Wanke Peter , Tan Yong , Searcy Cory 
Published: January 2025

AbstractA key discussion in the current management literature is how businesses react to and can contribute to solving societal challenges while meeting the needs of their shareholders and their broader set of stakeholders. Most extant research focuses on corporate social responsibility (CSR) issues in large for‐profit corporations, but social enterprises are also critical given their ability to promote financial inclusion and focus on stakeholders' needs. This study explores the mediating role of total factor productivity (TFP) in the relationship between CSR and financial performance within social enterprises, using a sample of microfinance institutions (MFIs) from Latin America. Our analysis demonstrates TFP's critical role in translating CSR initiatives into sustainable financial outcomes and enhancing both economic and social objectives. Thus, our results may provide insights to regulators, policymakers, and practitioners, allowing them to better understand best practices and actions that foster stakeholders' trust and expectations, with the potential outcome of improving MFIs overall sustainability goals. Our findings are robust due to the use of a variety of methodological approaches to address possible endogeneity problems and alternative specifications of financial performance.
Complete Aqueous Defluorination of GenX (Hexafluoropropylene Oxide Dimer Acid Anion) by Pulsed Electrolysis with Polarity Reversal
Authors: Meng Ziyi , Wilsey Madeleine K. , Müller Astrid M. 
Published: January 2025

AbstractPer‐ and polyfluoroalkyl substances (PFAS) are extremely stable chemicals that are essential for modern life and decarbonization technologies. Yet PFAS are persistent pollutants that are harmful to human health. Hexafluoropropylene oxide dimer acid (GenX), a replacement for the PFAS chemical perfluorooctanoic acid, continues to pollute waterways. In this study, we report the complete defluorination of GenX through electrocatalysis in aqueous LiOH electrolytes, utilizing high surface area anodes consisting of pulsed laser in liquid synthesized [NiFe]‐(OH)₂ nanocatalysts on hydrophilic carbon fiber paper. Additional experiments with industrial nickel–iron alloy demonstrated exceptional stability for >100 hours. Including a brief interval of reversed polarity in pulsed electrolysis and optimizing the pulse train sequence enabled the complete defluorination of GenX. Our facile approach employs only nonprecious materials, does not require bisulfate or other auxiliary chemical agents that are consumed, and thus provides a promising strategy for alleviating the environmental impact of PFAS pollutants.
Catalytic Deconstruction of Commercial and End‐Of‐Life Polyurethane with Heterogeneous Hydrogenation Catalyst
Authors: An Wenqing , Liu Xin , Zhang Xiaodong , Gao Ruitong , Chen Zhaojun , Hou Yuandong , Du Hui 
Published: January 2025

AbstractPolyurethane (PU), as a thermoset polymer, is extensively utilized in various applications, such as refrigerator foams, sponges, elastomers, shoes, etc. However, the recycling of post‐consumed PU poses significant challenges due to its intricate and extensive crosslinking structures. Catalytic hydrogenation is one of the most effective methods for recycling PU waste, nevertheless, there is currently a lack for a hydrogenation catalyst that is both high‐performing, recyclable, and cost‐effective for breaking down post‐consumed PU materials. In this work, model PU and commercial PU were efficiently hydrodegraded into aromatic amines and polyol fractions by using a commercial NiMo/Al2O3 catalyst. Notably, the results indicated that PU waste can be efficiently degraded at a pressure of 5 MPa and at a temperature of 185 °C and yielding a significant amount of a valuable chemical monomers. With the assistance of hydrogenation catalyst, the C−N and C−O bonds with low energy barriers inside the polymer are cracked and the polymer hydrogenation process becomes feasible. This study demonstrates the capability of fluidized bed hydrogenation process, employing recyclable heterogeneous catalysts for the recycling of PU waste.
Titin gene mutations enhance radiotherapy efficacy via modulation of tumour immune microenvironment in rectum adenocarcinoma
Authors: Liu Hengchang , Liu Jialiang , Guan Xu , Zhao Zhixun , Cheng Pu , Chen Haipeng , Jiang Zheng , Wang Xishan 
Published: January 2025

AbstractObjectiveThis study investigates the impact of Titin (TTN) gene mutations on radiotherapy sensitivity in rectum adenocarcinoma (READ) by examining changes in the tumour immune microenvironment.MethodsData on gene expression and mutations in READ were obtained from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) databases. Bioinformatics analysis explored the correlation between TTN mutations and immune cell infiltration. In vitro, lentiviral vectors were used to assess TTN mutations' effects on ANKRD1 expression in two READ cell lines. ANKRD1 was overexpressed, and clonogenic assays evaluated radiotherapy sensitivity. Flow cytometry, immunofluorescence, and comet assays examined mutations' impact on cell cycle, apoptosis, and DNA damage response (DDR). An in vivo mouse model and formalin‐fixed paraffin‐embedded samples from locally advanced rectal cancer (LARC) patients before and after radiotherapy were analyzed, followed by prognostic evaluation.ResultsBioinformatics revealed that TTN mutations increase radiation sensitivity in LARC by slowing cell proliferation, promoting apoptosis, and reducing DDR. TTN mutations also inhibit ANKRD1 expression via JUN disruption and enhance CD4/CD8 T‐cell infiltration, improving anti‐tumour immunity and outcomes. Observations from the clinical study showed a substantial decline in ANKRD1 expression levels alongside a notable surge in the counts of CD4+ and CD8+ T cells after undergoing radiotherapy. Patients with TTN mutations, low ANKRD1 expression, and high densities of CD4+ and CD8+ T cells had longer 3‐year disease‐free survival in READ.ConclusionOur findings reveal that TTN mutations can serve as biomarkers for enhanced radiotherapy sensitivity in READ. By altering the tumour's immune microenvironment, these mutations may provide a novel target for personalized radiotherapy strategies, potentially improving therapeutic outcomes in patients with READ.Highlights
The association between TTN mutations and tumour mutation burden, as well as immune cell infiltration in READ, is examined.
TTN mutations enhance the radiation sensitivity of READ cells and weaken DNA damage repair in response to radiation.
TTN mutations increase the radiation sensitivity of READ cells by inhibiting ANKRD1.
The infiltration of CD8+ and CD4+ T cells induced by TTN mutations is essential for anti‐tumour immunity.
TTN mutations serve as a biomarker for the pathological response to preoperative radiotherapy in READ.
Exosome‐derived long non‐coding RNA AC010789.1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8/Wnt/β‐catenin signalling
Authors: Chu Shaojun , Jia Lingling , Li Yulong , Xiong Jiachao , Sun Yulin , Zhou Qin , Du Dexiang , Li Zihan , Huang Xin , Jiang Hua , Wu Baojin , Li Yufei 
Published: January 2025

AbstractBackgroundThe increased incidence of androgenic alopecia (AGA) causes adverse physiological and psychological effects on people of all genders. The hair follicle stem cells (HFSCs) have displayed clinical improvements on AGA. However, the molecular mechanism of HFSCs against AGA remains elusive.MethodsThe expression and prognosis of lncRNA AC010789.1 in AGA hair follicle tissues were assessed by qRT‐PCR analysis. CCK‐8, EdU and Transwell analysis were utilized to assess cell growth. The specific binding between AC010789.1 and FTO mediated m6A modification or the effect of AC010789.1 on hnRNPA2B1, S100A8 and Wnt/β‐catenin signaling expression was confirmed by bioinformatic analysis, RIP, RNA pull‐down and Western blot assay. The effects of Exosome‐loaded AC010789.1 prompted HFSCs proliferation and hair follicle regeneration were confirmed in hairless mice.ResultsWe herein found that the mRNA levels of lncRNA AC010789.1 were decreased in AGA tissue samples but increased in HFSCs of surrounding normal tissue samples. Overexpression (OE) of AC010789.1 promoted HFSC proliferation, DNA synthesis and migration as well as K6HF and Lgr5 upregulation, whereas knockdown of AC010789.1 showed the opposite effects. The total or AC010789.1 m6A levels were reduced and FTO demethylase was upregulated in AGA tissue samples, but these indicated the reverse results in HFSCs of surrounding normal tissue samples. FTO OE decreased AC010789.1 m6A levels and its mRNA levels in HFSCs and abolished AC010789.1‐induced HFSCs proliferation. In addition, AC010789.1 was identified to bind to m6A reader hnRNPA2B1, which was downregulated in AGA but upregulated in HFSCs of surrounding normal tissue samples. hnRNPA2B1 OE attenuated AC010789.1 knockdown‐induced inhibition of HFSCs proliferation. Moreover, AC010789.1 could bind to and enhance downstream S100A8 protein expression, which mediated Wnt/β‐catenin signaling to accelerate HFSCs proliferation. Exosome‐loaded AC010789.1 prompted HFSCs proliferation and hair follicle regeneration in mice.ConclusionsOur findings demonstrated that exosome‐derived lncRNA AC010789.1 modified by FTO and hnRNPA2B1 facilitated the proliferation of human HFSCs against AGA by activating S100A8/Wnt/β‐catenin signaling.Key points
Long non‐coding RNA (lncRNA) AC010789.1 was downregulated in hair follicle tissues from androgenic alopecia (AGA) and upregulated in hair follicle stem cells (HFSCs).
LncRNA AC010789.1 promoted the proliferation and migration of HFSCs.
FTO/hnRNPA2B1‐mediated m6A modification of lncRNA AC010789.1 promoted HFSCs growth by activating S100A8/Wnt/β‐catenin signalling.
Exosome‐derived AC010789.1 accelerated HFSCs proliferation.
Whole Genome Sequencing Reveals Genetic Differences Between Symbiodiniaceae Populations Among Reproductively and Geographically Isolated Acropora Colonies in Western Australia
Authors: Eriksson Sanna Y. , Matz Mikhail V. , Vize Peter D. , Rosser Natalie L. 
Published: January 2025

ABSTRACTSignificant genetic differentiation between Symbiodiniaceae populations in coral hosts can be induced by a range of factors including geography, latitude, depth, temperature and light utilisation. The conventional method of measuring Symbiodiniaceae diversity involving the ITS2 region of rDNA has several limitations, stemming from insufficient genetic resolution and the multi‐copy nature of the marker. This could be improved by using higher throughput whole genome sequencing to identify fine‐scale population genetic differences and provide new insight into factors influencing coral‐Symbiodiniaceae associations. The aim of this study was to investigate the genetic diversity of Symbiodiniaceae populations using low‐coverage whole genome sequencing in sympatric populations of Acropora cf. secale and allopatric populations of Acropora millepora that reproduce in different seasons in Western Australia. Genetic diversity of Symbiodiniaceae populations in these two species was examined using principal coordinates analysis and permutational analysis of variance. This analysis revealed that while all colonies were dominated by Cladocopium, there was a significant genetic difference between Symbiodiniaceae populations in both species. In A. millepora, this variation could be due to the latitudinal variation between populations or differences in reproductive seasonality, but in sympatric populations of A. cf. secale, genetic differences between Symbiodiniaceae populations were clearly aligned with the reproductive seasonality of the coral host. The use of whole genome sequencing improved the sensitivity to detect Symbiodiniaceae genetic population structure between coral populations, which increases our ability to identify genetic and potentially functional differences associated with variation in Symbiodiniaceae populations.
Incorporating the HPLC‐ESI‐Q‐TOF‐MS profiles with the biochemical properties of eight Salvia species
Authors: Llorent‐Martínez Eulogio J. , Nilofar  , Sinan Kouadio Ibrahime , Darendelioglu Ekrem , Bahsi Muammer , Polat Rıdvan , Cakilcioglu Ugur , Orlando Giustino , Ferrante Claudio , Zengin Gokhan 
Published: January 2025

AbstractSalvia, a widely recognized genus globally esteemed for its traditional and medicinal applications, prompted our investigation into the methanol and water extracts of eight Salvia species native to Turkey. These species included S. aucheri, S. candidissima, S. divaricata, S. virgata, S. multicaulis, S. palestina, S. trichoclada, and S. cerino‐pruinosa. Our study aimed to assess their biological properties and chemical composition. Utilizing HPLC‐ESI‐Q‐TOF‐MS, we identified chemical constituents in the extracts, while antioxidant (radical quenching, reducing power, and metal chelating) and enzyme inhibitory (amylase, glucosidase, tyrosinase, and cholinesterase) activities were evaluated for biological activities. One hundred thirty‐one compounds were characterized in the tested extracts. Although many compounds belonging to different chemical families were identified, the main compounds in all the extracts were rosmarinic and sagerinic acids, along with several salvianolic acid isomers. Notably, the methanol extracts displayed superior antioxidant properties overall, with S. cerino‐pruinosa exhibiting the highest activity among them, except for metal chelating. Similar to the antioxidant test results, the methanol extracts were more active than the water extracts in the enzyme inhibition tests. Multivariate analysis further highlighted the distinctiveness of the water extract of S. cerino‐pruinosa. In conclusion, our findings underscore the biopharmaceutical potential of the tested Salvia species, suggesting their significance as sources of bioactive agents for health‐promoting applications.