bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural, Dielectric and Ferroelectric Properties of Cu2+ and Cu2+/Bi3+ doped BCZT Lead-free Ceramics: A Comparative Study
Authors: Kumari Sapna , Kumar Amit , Kumar V. , Dubey S. K. , Goyal P. K. , Kumar Suresh , Sharma A. L. , Arya Anil 
Published: March 2021

Abstract
Perovskite type Ba0.98Ca0.02Zr0.02Ti0.98O3 (BCZT), Ba0.98Ca0.02Zr0.02Ti0.976Cu0.008O3 (BCZTC) and Ba0.9725Bi0.005Ca0.02Zr0.02Ti0.976Cu0.008O3 (BCZTCB) lead-free ceramics were synthesised via solid-state reaction method at a sintering temperature of ~ 1380°C. Effects of CuO and Bi2O3/CuO doping on structural, microstructural, dielectric, and ferroelectric properties were investigated systematically. X-ray diffraction technique confirmed the existence of pure perovskite phase with the tetragonal structure in pure and in the doped BCZT ceramics at room temperature. The dielectric analysis demonstrated two anomalies around 24°C and 126°C for BCZT, which were identified as orthorhombic to tetragonal (TO-T) and tetragonal to cubic (TC) phase transition temperature, respectively. The TO-T temperature shifted to below 16°C, while the TC increased to 132°C for the BCZTCB sample. The physical mechanisms of the conduction processes were investigated through impedance spectroscopy and the values of resistance, conductivity, and activation energies associated with the grain and grain boundaries were evaluated. The activation energy was determined to be higher for doped samples than for pure BCZT. Further, the dopant-dependent ferroelectric nature of the ceramic samples was evidenced by the analysis of characteristic hysteresis loop, and a value of remnant polarisation (Pr = 4.59 µC/cm2) was obtained for the BCZTCB ceramic sample. Furthermore, the d33 value, which was 54 pC/N for pure BCZT, was determined to be 140 pC/N and 64 pC/N for BCZTC and BCZTCB, respectively.
Multi-analytical techniques in characterization and identification of Chinese historical rubbings
Authors: Yao Na , Zhan Xiangsheng , Ma Qinglin , Wei Shuya 
Published: March 2021

Abstract
For authenticity and conservation purposes, the precious historical rubbings preserved in Wuyuan Museum were studied by multi-analytical techniques including Pyrolysis gas chromatography-mass spectrometry (Py-GC/MS), SEM-EDS and Herzberg staining method. Through Py-GC/MS analyses, five types of constituents could be detected: (1) polycyclic aromatic hydrocarbons from soot; (2) retene and methyl dehydroabietate from tar of conifer wood; (3) marker compounds of egg; (4) additives of menthol and curcumene compounds; (5) biochemical compounds of bark paper. Based on this analytical results, the ink type, binding media and additives in the ink, as well as the fiber origin source of the rubbing paper could be concluded. The materials information of the rubbings obtained through this study could not only provide evidence for its authenticity, but also supply scientific support for its conservation and restoration.
Combined Analysis of C-reactive Protein in Pleural Fluid and Serum is Effective in the Differential Diagnosis of Exudative Pleural Effusions
Authors: Qu Shuo-yao , Zhang Yong , Wu Shuo , Wang Ming-ming , Liu Ling-li , Yang Xue-min , Shan Hui-liang , Yang Juan-li , Chen Pei , Ti Xin-Yu 
Published: March 2021

Abstract
Background: Exudative pleural effusion (EPE) is one of the common pleural manifestations of various diseases. Differential diagnosis of EPE is imperative clinically as it identifies different causes of EPE, thereby, providing effective treatments. Thoracoscopy is a useful tool for differential diagnosis of EPE. However, some patients would refuse thoracoscopic examination due to its invasive nature. In addition, the specificity and sensitivity of existing routine tests of EPE are less satisfying. Therefore, there is a great need to establish an effective method for differential diagnosis of EPE.Methods: This study was a single-institution retrospective analysis of diagnostic efficiency of C-reactive protein (CRP) and procalcitonin (PCT) between March 2018 and September 2018. Eighty-seven patients diagnosed with EPE were enrolled. All patients underwent diagnostic thoracentesis. And the EPE was examined using biochemical, routine, microbiological, and cytological methods. Pathological cytology detection was of necessity for those with the suspicion of malignant PE. Benign PE comes from patients with pneumonia, empyema and tuberculosis. The levels of CRP and PCT of EPE and serum were measured before the treatment. Correlation analysis and receiver-operating characteristic (ROC) curve analysis were conducted to determine the underlying relationship between levels of CRP and PCT, and differential diagnosis.Results: Receiver operating characteristic analysis showed that the sensitivity and specificity for the analysis of pleural fluid CRP (p-CRP) are higher (cut-off: 17.55 pg/mL; sensitivity: 75.00 %, specificity: 83.90%) than that of serum CRP (s-CRP, cut-off: 23.90 pg/mL; sensitivity: 71.00 %, specificity: 80.4%) in the differential diagnosis for EPE. However, the analysis of pleural fluid PCT (p-PCT) and serum PCT (s-PCT) didn’t demonstrate correlations with EPE. Combined analysis of p-CRP (cut-off: 17.55 mg/dL) with s-CRP (cut-off: 23.9 pg/mL) showed the highest diagnostic accuracy (88.4%) in diagnosing infectious EPE.Conclusions: The data support the close relationship between combined analysis of p-CRP with s-CRP and effective and accurate differential diagnosis of EPE, due to its higher sensitivity and specificity. However, as a highly sensitive marker to diagnose bacterial infections, neither s-PCT nor p-PCT, showed correlations with the differential diagnosis of EPE.
Mucopolysaccharidosis VII in Brazil: Natural History and Clinical Findings
Authors: Giugliani Roberto , Barth Anneliese Lopes , Dumas Melissa Rossi Calvão , Franco José Francisco da Silva , Giuliani Liane de Rosso , Grangeiro Carlos Henrique Paiva , Horovitz Dafne Dain Gandelman , Kim Chong Ae , Leão Emilia Katiane Embiruçu de Araújo , Medeiros Paula Frassinetti Vasconcelos de , Miguel Diego Santana Chaves Geraldo , Moreira Maria Espírito Santo Almeida , Santos Helena Maria Guimarães Pimentel dos , Silva Luiz Carlos Santana da , Silva Luiz Roberto da , Souza Isabel Neves de , Nalin Tatiele , Garcia Daniel 
Published: March 2021

Abstract
Background: Mucopolysaccharidosis type VII (MPS VII), also known as Sly syndrome, caused by deficiency of the lysosomal enzyme β-glucuronidase, is an ultra-rare disorder with scarce epidemiological data and few publications about natural history and clinical spectrum. Methods: We conducted a case series report which included retrospective data from all MPS VII patients diagnosed through the “MPS Brazil Network” who were known to be alive in 2020 in Brazil (N=13). Clinical data were obtained from a review of the medical records and descriptive statistics and variables were summarized using counts and percentages of the total population.Results: The majority of the patients were from the Northeast region of Brazil. Among the signs and symptoms that raised the clinical suspicion of MPS, coarse face was the most frequent; 58% of the patients had a history of non-immune hydrops fetalis. All the subjects presented short neck and trunk. The majority presented typical phenotypical signs of MPS disorders. They all presented neurodevelopmental delay and cognitive impairment. About half of this cohort had knees deformities. Dysostosis multiplex was identified in almost all patients and cardiomyopathy was less frequent than observed in other types of MPSs. The mean age at diagnosis was 5 years, ranging from 1 to 14 years. Almost all patients (12/13) were homozygous for the c.526C>T (p.Leu176Phe) mutation. A novel variant of the GUSB gene was found, the c.875T>C (p.Leu292Pro), in a compound heterozygous with the c.526C>T (p.Leu176Phe) variant.Conclusions: This case series is the biggest data collection of MPS VII patients alive in Latin America. The overall clinical picture of the MPS VII patients is very similar to other MPS disorders, including broad spectrum of severity and delayed diagnosis.
Bio-Sequence Stratigraphy of Asmari Formation in the Southeast of Norabad (Zagros Basin, SW Iran)
Authors: Dehghanian Mohammadsadegh 
Published: March 2021

Abstract
Asmari Formation is the thick sequence of carbonate sediment in the range of Oligocene-Miocene which is deposited in the foreland basins of the Zagros and is considered as the original and most famous reservoir rock of Zagros basin. To study of lithostratigraphic units and sequence stratigraphy of this Formation, the section in the southeast of Norabad was selected. Field study indicated that Asmari Formation possessed the thickness of 401.5m and included 9 lithostratigraphic units. According to the study of microfacies, Stacking pattern and identification of main sequence level, three depositional sequences including two-second order and one-third order sequence were recognized. The sea-level curve in the studied section indicated that it was correspondence to the global sea level curve. These facies deposited in five environmental sedimentations as follow Open Sea Shelf (Fore Barrier), Bar, Lagoon, Back bar shelf, and Shoal. The environment is part of a carbonate platform that has been formed on an open shelf. In addition, according to the Study of foraminifer dispersion pattern the range of Asmari Formation in Norabad was suggested to be Oligocene (Rupelian- Chattian) to lower Miocene (Aquitanian- Burdigalian).
The combination of serum BDNF, cortisol and IFN-gamma can effectively diagnose major depressive disorder
Authors: Chen Suzhen , Zhang Yuqun , Yuan Yonggui 
Published: March 2021

Abstract
Background

Misdiagnosis and ineffective treatment are common in major depressive disorder (MDD) in current clinical practice, while the combination of various proteins involved in the pathogenesis of MDD may assist the correct diagnosis. The study aimed to explore whether the combination of serum inflammatory, stress, and neurotrophic factors could be helpful for the diagnosis of MDD, and to investigate the predictors associated with early symptom improvement.

Methods

Baseline serum levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, IL-1beta, tumor necrosis factor (TNF)-alpha, interferon (INF)-gamma, cortisol and brain-derived neurotrophic factor (BDNF) were detected in 30 MDD patients and 30 age- and gender-matched healthy controls. 17-item Hamilton Depression Rating Scale (HAMD-17) and Hamilton Anxiety Rating Scale (HAMA) were applied to assess depressive and anxious symptoms both at baseline and 2 weeks after antidepressant treatment. Stepwise multiple linear regression was employed to identify the early efficacy predictiors; while a logistic regression model was built with above proteins and area under receiver operating characteristic (AUC) curve was calculated to evaluate the model’s diagnostic power.

Results

Multiple linear regression revealed that baseline socres of retardation ( β =-0.432, P =0.012) and psychological anxiety ( β =-0.423, P =0.014) factors were negatively associated with the reduction rate of HAMD-17. A simple and efficient diagnostic model was established by forward stepwise logistic regression and the model achieved an AUC of 0.884, with 86.7% sensitivity and 83.3% specificity.

Couclusions

The results showed that combining serum BDNF, cortisol and IFN-gamma could aid the diagnosis of MDD, while baseline retardation and psychological anxiety may negatively predict the early symptom improvement.
Development of arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic Acid/protein kinase D signaling&nbsp;
Authors: Jiang Yinan , Guo Yichen , Hao Jinjin , Guenter Rachael , Lathia Justin , Beck Adam W. , Hattaway Reagan , Hurst Douglas , Wang Qiming Jane , Liu Yehe , Cao Qi , Krontiras Helen , Chen Herbert , Silverstein Roy , Ren Bin 
Published: March 2021

Abstract
Breast cancer stem cells (BCSCs) are essential for cancer growth, metastasis and recurrence. The regulatory mechanisms of BCSC interactions with the vascular niche within the tumor microenvironment (TME) and their self-renewal are currently under extensive investigation. We have demonstrated the existence of an arteriolar niche in the TME of human BC tissues. Intriguingly, BCSCs tend to be enriched within arteriolar niche in human estrogen receptor positive (ER+) BC and bi-directionally interact with arteriolar endothelial cells (ECs). Mechanistically, this interaction is driven by the lysophosphatidic acid (LPA)/protein kinase D (PKD-1) signaling pathway, which promotes both arteriolar differentiation of ECs and self-renewal of CSCs. This study indicates that CSCs may enjoy blood perfusion to maintain their stemness features. Targeting the LPA/PKD-1 signaling pathway in combination with inhibition of CD36 function may have therapeutic potential to curb tumor progression by disrupting the arteriolar niche and eliminating CSCs.
UBE2V2 promotes metastasis by regulating EMT and predicts a poor prognosis in lung adenocarcinoma.
Authors: Yang Zheng , Xue Qiang , Du Caishen , Zhen Miaosen , Xu Jianxun , Zhang Pengfei , Zhao Jianmei , Shi Guanglin , Liu Xianchen , Tang Zhiyuan , Zhou Xiaoyu 
Published: March 2021

Abstract

Background: Belonging to the ubiquitin-conjugating enzymes (E2s) family, UBE2V2 demonstrated a remarkable tumourigenic ability in many kinds of cancers. However, the interrelationship between UBE2V2 expression and morbidity of lung adenocarcinoma (LUAD) is still unknown. Methods: By using TCGA predictions and clinical tissue samples, we assessed the expression of UBE2V2 mRNA and protein in LUAD and analyzed its relationship with different clinicopathological factors as well as survival prognosis. Besides, we further studied the EMT signaling pathway that promotes LUAD metastasis and other phenotypic experiments by using lentivirus to transfect LUAD cells. Results: Our research results showed that compared with normal tissues, the expression of UBE2V2 mRNA and protein in LUAD was significantly increased (P<0.001). UBE2V2 might be considered as an independent prognostic molecule for LUAD patient survival prognosis based on TCGA prediction (HR:1.497 P=0.012) and immunohistochemical analysis (ICH) (HR:1.842 P=0.042). ICH showed that UBE2V2 was related to the following clinicopathological factors, including gender (P=0.021), stage (P=0.042), lymph node metastasis (P=0.021) and differentiated degree (P=0.015). Finally, knockdown of UBE2V2 significantly reduced the migration ability by regulating the EMT pathway. The knockdown of UBE2V2 inhibited cells proliferation, reduced the proportion of cells in S phase and promoted cell apoptosis. Interestingly, UBE2V2 expression is negatively correlated with B cells, CD4 + T cells, macrophages and dendritic cells. Conclusions: In summary, UBE2V2 might play an important role in the progression of LUAD.
A quantitative description of the spatial-temporal distribution and evolution pattern of world cultural heritage
Authors: Liang Yongqi , Ruixia Yang , Pu Wang , Anlin Yang , Guolong Chen 
Published: March 2021

Abstract
Depicting the temporal and spatial evolution pattern of global world cultural heritage systematically and finely is the basis of heritage recognition and protection. In this study, 869 world cultural heritage inscriptions (through 2019) were selected as the research objects, and the times and types of each World Heritage site were manually annotated from more than 5000 pieces of data. Through time series modelling, the advantages of and changes in heritage declarations in different regions and periods were analysed, and the impact of heritage strategy on the number of heritage sites included in each region was evaluated. The results showed that the implementation of heritage policy greatly impacted each region, especially on the number of heritage sites in Asia and the Pacific region. Using the heritage era to carry out modelling analysis, from the perspective of the integrity of historical heritage cultural types, it is considered that there may be cultural heritage sites in the Caribbean and Latin America that have not been given enough attention. The modelling analysis results of era attributes can support the fairness of heritage determination. By calculating the frequency and peak value of heritage sites at the national scale, the frequency and peak value of each country in the top 10 list are used to characterize the ability of national declarations of cultural heritage and reveal the differences in the ability of each member country to declare heritage sites and the heritage era. By calculating the distribution density of the heritage era, this study finds that the world’s cultural heritage is not concentrated in the Middle Ages (600–1450) but the periods of Reformation and Exploration (1450–1700) and Progress and Empire (1850–1914). The above analysis shows that there are imbalances and strategic adjustment effects concerning regions, countries, eras and types in World Heritage list development. The composition types of heritage are complex, and the combination types have obvious changes in different periods. It is suggested that the strategy of world cultural heritage collection should be further optimized to fully guarantee the balance of regions, countries and types, and the heritage value should be fully considered in heritage protection with more diversity and complexity of types.
Development and Delphi validation of a Best Possible Medication History form
Authors: Hoornaert Camille , Pochet Stéphanie , Lorent Sophie 
Published: March 2021

Abstract
Background The Best Possible Medication History (BPMH) form is the first step for medication reconciliation across the continuum of care but getting a complete picture of the patient’s current medication is a particularly difficult challenge.Objective To develop and validate a standardized BPMH form that could be used by clinical pharmacists. Setting Belgium hospitalsMethod The draft version was presented to a focus group and was adapted following their comments. A three-rounds e-Delphi method was used to validate content, usability and face validity of BPMH form. We supplemented the quantitative analysis with a qualitative analysis of comments for each Delphi round.Main outcome measure To select tabs and items to be included in BPMH.Results The draft BPMH form contained 23 items grouped into 8 tabs. Refinement of these tabs and items by the focus group resulted in 7 tabs and 21 items, which were included in the Delphi survey. The consensus was obtained for all tabs within the second round (p= 0,072). The research group included 20 items following the qualitative analysis of the experts' comments despite a level of agreement of 76% (16/21) in third round.Conclusion A structured BPMH form could be a reference as well for inpatient prescribing as for any home medication modification at the time of discharge. Improving medication safety is fundamental for patient safety and is a priority target for healthcare systems. The next step might be to integrate this tool through medical record to assist physicians, nurses and hospital pharmacists in their practice.
Improvement weldability of dissimilar joints (Ti6Al4V/Al6013) for aerospace industry by Laser beam welding
Authors: Ribeiro Anderson C. N. Clayton Nascimento , Siqueira Rafael Humberto Mota de , Lima Milton Sergio Fernandes de , Giorjão Rafael Arthur Reghine , Abdalla Antônio Jorge 
Published: March 2021

Abstract
The discovery of new metal alloys and the technological advancement in welding processes are key resources for the aerospace industry to obtain cost reduction and better reliability. Thus, welded joints of dissimilar materials such as aluminum and titanium alloys has been explored due to its combined low density and high mechanical performance. Otherwise, welding of dissimilar metals may present deleterious factors to the welded joint as the formation of intermetallic and/or brittle second phase and residual stress. This project investigates the weldability of dissimilar welded joint (Al6013/Ti-6Al-4V) by Laser beam welding. The approach will be done in terms of mechanical properties and microstructural characterization. For this purpose, optimal laser offset from the joint line and the related heat input has been found. It was observed that offset controls the amount of the intermetallic compound layer in the fusion zone. Large pores were observed on the Al side of the weld metal when the offset is zero. The microstructure on the aluminum side consisted of \(\alpha\)-Al grains and the dispersed precipitates. Heat input and offset also influenced in the volumetric fraction of the precipitates. Martensite \({{\alpha }}^{{\prime }}\) and secondary acicular \({\alpha }\) phase was found in the titanium side. Furthermore, intermetallic compound of TiAl base phase such as TiAl, Ti3Al4, and Ti2Al3 was formed. Tensile strength of welded joint was 60% of the Al alloy. In addition, for the same offset and higher heat input, there was an increase in the hardness of the interface.
The South Inylchek Glacier Activity Analysis over a Ten-year Interval in Surface Velocity with Multi-source Spaceborne Imagery
Authors: zhang Qimin , Zhang Lu , Lv Mingyang , Sun Yidan , Yan Shiyong 
Published: March 2021

Abstract
Ice movement is one of the most important characteristics in describing mountain glacier activity, which is a sensitive natural indicator of climate change. However, the short-term ice movement with a single data source could not precisely and sufficiently demonstrate the response of glaciers to climate change. In order to extract the reliable signal corresponding to climate change, the long-term monitoring of glacier movement should be widely exploited. This paper presents the ice motion distribution of the South Inylchek Glacier by improving pixel tracking algorithm with both synthetic aperture radar and optical imagery in 2007-2008 and 2017-2018. The analysis in spatiotemporal characteristics of the glacier velocity indicates that the South Inylchek Glacier remained almost stable in a ten-year interval with the average velocity of 32cm/d, which are computed with quasi-synchronization multi-source imagery. And the consistency of the velocity results was also verified with both optical and SAR imagery during the same period. Therefore, it would be valuable in expanding the research temporal cycle of glacier movement by uniting multi-source data. We also suggest that long-term ice motion should be collected for further analysis in mass balance prediction and assessing the climate change effects in the High Mountain Asia.