bluuebunny/crossref_metadata_2025_split huggingface dataset:
B7-H3 as a Target for CAR-T Cell Therapy in Skull Base Chordoma
Authors: Long Cheng , Li Gaowei , Zhang Chengyun , Jiang Tao , Li Yanjun , Duan Xin , Zhong Gang 
Published: November 2021

Objectivechordomas are rare bone tumors with few therapeutic options. Skull base and sacrum are the two most common origin sites. Immunotherapies are emerging as the most promising approaches to fight various cancers. This study tends to identify new cell surface targets for immunotherapeutic options of skull base chordomas.Methodswe profiled 45 skull base chordoma clinical samples by immunohistochemistry for the expression of six CAR-Targets (PD-L1, B7-H3, B7-H4, VISTA, HER2 and HER3). In addition, we generated B7-H3 targeted CAR-T-cells and evaluated their antitumor activities in vitro.ResultsWe found that B7-H3 was positively stained in 7 out of 45 (16%) chordoma samples and established an expression hierarchy for these antigens (B7-H3 &gt; HER3 &gt; PD-L1 &gt; HER2 = VISTA = B7-H4). We then generated a B7-H3 targeted CAR vector and demonstrated that B7-H3-CAR-T-cells recognized antigen positive cells and exhibited significant antitumor effects, including suppression of tumor spheroid formation, CAR-T-cell activation and cytokine secretion.ConclusionsOur results support B7-H3 might serve as a promising target for CAR-T-cell therapies against chordomas.
Development and Validation of an MRI-Based Nomogram Model for Predicting Disease-Free Survival in Locally Advanced Rectal Cancer Treated With Neoadjuvant Radiotherapy
Authors: Chen Silin , Tang Yuan , Li Ning , Jiang Jun , Jiang Liming , Chen Bo , Fang Hui , Qi Shunan , Hao Jing , Lu Ningning , Wang Shulian , Song Yongwen , Liu Yueping , Li Yexiong , Jin Jing 
Published: November 2021

ObjectivesTo develop a prognostic prediction MRI-based nomogram model for locally advanced rectal cancer (LARC) treated with neoadjuvant therapy.MethodsThis was a retrospective analysis of 233 LARC (MRI-T stage 3-4 (mrT) and/or MRI-N stage 1-2 (mrN), M0) patients who had undergone neoadjuvant radiotherapy and total mesorectal excision (TME) surgery with baseline MRI and operative pathology assessments at our institution from March 2015 to March 2018. The patients were sequentially allocated to training and validation cohorts at a ratio of 4:3 based on the image examination date. A nomogram model was developed based on the univariate logistic regression analysis and multivariable Cox regression analysis results of the training cohort for disease-free survival (DFS). To evaluate the clinical usefulness of the nomogram, Harrell’s concordance index (C-index), calibration plot, receiver operating characteristic (ROC) curve analysis, and decision curve analysis (DCA) were conducted in both cohorts.ResultsThe median follow-up times were 43.2 months (13.3–61.3 months) and 32.0 months (12.3–39.5 months) in the training and validation cohorts. Multivariate Cox regression analysis identified MRI-detected extramural vascular invasion (mrEMVI), pathological T stage (ypT) and perineural invasion (PNI) as independent predictors. Lymphovascular invasion (LVI) (which almost reached statistical significance in multivariate regression analysis) and three other independent predictors were included in the nomogram model. The nomogram showed the best predictive ability for DFS (C-index: 0.769 (training cohort) and 0.776 (validation cohort)). It had a good 3-year DFS predictive capacity [area under the curve, AUC=0.843 (training cohort) and 0.771 (validation cohort)]. DCA revealed that the use of the nomogram model was associated with benefits for the prediction of 3-year DFS in both cohorts.ConclusionWe developed and validated a novel nomogram model based on MRI factors and pathological factors for predicting DFS in LARC treated with neoadjuvant therapy. This model has good predictive value for prognosis, which could improve the risk stratification and individual treatment of LARC patients.
The Deficits of Individual Morphological Covariance Network Architecture in Schizophrenia Patients With and Without Violence
Authors: Shen Danlin , Li Qing , Liu Jianmei , Liao Yi , Li Yuanyuan , Gong Qiyong , Huang Xiaoqi , Li Tao , Li Jing , Qiu Changjian , Hu Junmei 
Published: November 2021

Background: Schizophrenia is associated with a significant increase in the risk of violence, which constitutes a public health concern and contributes to stigma associated with mental illness. Although previous studies revealed structural and functional abnormalities in individuals with violent schizophrenia (VSZ), the neural basis of psychotic violence remains controversial.Methods: In this study, high-resolution structural magnetic resonance imaging (MRI) data were acquired from 18 individuals with VSZ, 23 individuals with non-VSZ (NSZ), and 22 age- and sex-matched healthy controls (HCs). Whole-brain voxel-based morphology and individual morphological covariance networks were analysed to reveal differences in gray matter volume (GMV) and individual morphological covariance network topology. Relationships among abnormal GMV, network topology, and clinical assessments were examined using correlation analyses.Results: GMV in the hypothalamus gradually decreased from HCs and NSZ to VSZ and showed significant differences between all pairs of groups. Graph theory analyses revealed that morphological covariance networks of HCs, NSZ, and VSZ exhibited small worldness. Significant differences in network topology measures, including global efficiency, shortest path length, and nodal degree, were found. Furthermore, changes in GMV and network topology were closely related to clinical performance in the NSZ and VSZ groups.Conclusions: These findings revealed the important role of local structural abnormalities of the hypothalamus and global network topological impairments in the neuropathology of NSZ and VSZ, providing new insight into the neural basis of and markers for VSZ and NSZ to facilitate future accurate clinical diagnosis and targeted treatment.
Effect of Strain Rate on the Mechanical Properties of Cu/Ni Clad Foils
Authors: Wang Haiyang , Wang Chuanjie , Zhang Linfu , Chen Gang , Zhu Qiang , Zhang Peng 
Published: November 2021

The performance of clad foils in microforming deserves to be studied extensively, where the strain rate sensitivity of the clad foil concerning the forming performance is a crucial factor. In this paper, the strain rate sensitivity of the mechanical properties of coarse-grained (CG) Cu/Ni clad foils in the quasi-static strain rate range (ε˙=10−4 s−1~10−1 s−1) is explored by uniaxial tensile tests under different strain rates. The results show that the strength and ductility increase with strain rate, and the strain rate sensitivity m value is in the range of 0.012~0.015, which is three times the value of m for CG pure Cu. The fracture morphology shows that slip bands with different directions are entangled in localized areas near the interface layer. Molecular dynamics simulations demonstrate the formation of many edged dislocations at the Cu/Ni clad foils interface due to a mismatch interface. The improved ductility and strain rate sensitivity is attributed to the interaction and plugging of the edged dislocations with high density in the interface layer. Additionally, the influence of size effect on mechanical properties is consistently present in the quasi-static strain rate range. This paper helps to understand the strain rate sensitivity of CG clad foils and to develop clad foils in microforming processes.
Bangladeshi Native Vehicle Classification Based on Transfer Learning with Deep Convolutional Neural Network
Authors: Hasan Md Mahibul , Wang Zhijie , Hussain Muhammad Ather Iqbal , Fatima Kaniz 
Published: November 2021

Vehicle type classification plays an essential role in developing an intelligent transportation system (ITS). Based on the modern accomplishments of deep learning (DL) on image classification, we proposed a model based on transfer learning, incorporating data augmentation, for the recognition and classification of Bangladeshi native vehicle types. An extensive dataset of Bangladeshi native vehicles, encompassing 10,440 images, was developed. Here, the images are categorized into 13 common vehicle classes in Bangladesh. The method utilized was a residual network (ResNet-50)-based model, with extra classification blocks added to improve performance. Here, vehicle type features were automatically extracted and categorized. While conducting the analysis, a variety of metrics was used for the evaluation, including accuracy, precision, recall, and F1 − Score. In spite of the changing physical properties of the vehicles, the proposed model achieved progressive accuracy. Our proposed method surpasses the existing baseline method as well as two pre-trained DL approaches, AlexNet and VGG-16. Based on result comparisons, we have seen that, in the classification of Bangladeshi native vehicle types, our suggested ResNet-50 pre-trained model achieves an accuracy of 98.00%.
The effect of aerosol treatments with calcium-containing preparation on grape quality indicators during long-term storage
Authors: Романов А.В. , Бойко В.А. , Левченко С.В. , Белаш Д.Ю. 
Published: November 2021

В статье представлены результаты применения аэрозольных обработок кальций-содержащим препаратом «Мастер Грин Ca», дана оценка показателей качества винограда в процессе длительного хранении. Исследования проводились в течение 2020 г. в условиях Республики Крым на столовых сортах винограда: Италия, Ред Глоуб, Шоколадный и Молдова. Применение аэрозольных обработок способствовало изменению динамики относительного сахаронакопления сортов Молдова, Ред Глоуб и Италия, к концу хранения массовая концентрация сахаров превышала контрольные значения в диапазоне 3,9-17,6 %. Отмечено снижение активности полифенолоксидазы в опытных вариантах: у сорта Италия после 30 и 90 суток хранения - на 43 и 5 % соответственно, у сорта Ред Глоуб к концу хранения активность снизилась на 40,8 %. Установлено снижение значений естественной убыли массы винограда при применении аэрозольных обработок исследуемым препаратом: у сорта Ред Глоуб - на 44,6 %, у сорта Шоколадный - на 8,5 %, у сортов Молдова и Италия - на 24,4 %. Аэрозольные обработки оказали положительное влияние на органолептические показатели в период хранения, обеспечив гибкость гребня, сохранность естественного окраса, тургора ягод и гармоничности вкуса. Образцы винограда, обработанные препаратом «Мастер Грин Ca», были оценены на уровне 7,71 балла (Ред Глоуб) и 8,93 балла (Италия).
The article presents the results of using aerosol treatments with calcium-containing preparation Master Green Ca, the assessment of grape quality indicators in the process of long-term storage is given. The studies were carried out during 2020 in the conditions of the Republic of Crimea on table grapevine cultivars: ‘Italia’, ‘Red Globe’, ‘Shokoladnyi’ and ‘Moldova’. Using of aerosol treatments contributed to changes in dynamics of relative sugar accumulation in the cultivars ‘Moldova’, ‘Red Globe’ and ‘Italia’; by the end of storage, the mass concentration of sugars exceeded the control values in the range of 3.9-17.6%. A decrease in the polyphenol oxidase activity in experimental variants was registered: for the cultivar ‘Italia’ after 30 and 90 days of storage - by 43 and 5%, respectively; for the cultivar ‘Red Globe’ by the end of storage the activity decreased by 40.8%. A decrease in the values of natural loss of grape weight when using aerosol treatments with the studied preparation was established for the cultivars: ‘Red Globe’ - by 44.6%, ‘Shokoladnyi’ - by 8.5%, ‘Moldova’ and ‘Italia’ - by 24.4%. Aerosol treatments had a positive effect on organoleptic characteristics during storage ensuring preservation of stem flexibility, natural color, turgor of berries and balanced flavor. Grape samples treated with Master Green Ca preparation were rated at the level of 7.71 points (‘Red Globe’) and 8.93 points (‘Italia’).
Hydrochemical modeling of migration of dissolved oil products in groundwater
Authors: Кузьмин В.В. , Болдырев К.А. 
Published: November 2021

Изложена методика прогнозирования распространения нефтепродуктов группы BTEX (бензол, толуол, этилбензол, ксилолы) в подземных водах на основе гидрохимического моделирования с учетом изменения окислительно-восстановительных и кислотно-щелочных свойств раствора в процессе биодеградации нефтепродуктов. Представлена геохимическая модель биологического разложения нефтепродуктов комплекса BTEX на основе модифицированной кинетики Моно с учетом реакций между акцепторами, продуктами реакции биодеградации и неорганическими компонентами раствора. Приведены примеры геохимического моделирования, демонстрирующие важность учета процессов, связанных с изменением гидрогеохимической обстановки в подземных водах при разложении углеводородов. Разработанная модель может быть использована для выполнения геохимических прогнозов распространения легких нефтепродуктов в подземных водах, проведения работ в рамках оценки воздействия на природную среду, разработки систем инженерной защиты подземных вод от загрязнения нефтепродуктами.
A method for predicting the spread of BTEX group oil products (benzene, toluene, ethylbenzene, xylenes) in groundwater based on hydrochemical modeling with account of changes in the redox, acidity or alkalinity of the solution during the biodegradation of oil products is stated. A geochemical model of the biological decomposition of oil products of BTEX group based on modified Mono kinetics with account of the reactions between acceptors, biodegradation products and inorganic components of the solution is presented. Examples of geochemical modeling are given that demonstrate the importance of taking into account the processes associated with the changes in the hydrogeochemical environment in groundwater during the decomposition of hydrocarbons. The developed model can be used to carry out geochemical predictions of the spread of light-end oil products in groundwater, to carry out works within the framework of estimating the environmental impact, and to develop systems for engineering protection of groundwater from oil pollution.
Developing Competitive Advantages in the Agricultural Sector in the Context of Environmental Sustainability: Environmental Land Rent
Authors: Malysh E. V. 
Published: November 2021

Aim. The presented study aims to propose ways of developing new competitive advantages with allowance for the requirements of environmental sustainability by systematizing theoretical approaches and analyzing the institutional aspects of land rent.Tasks. The authors show systemic trends in the formation of environmental rents in the agricultural sector and propose a plan for developing competitive advantages in the context of environmental sustainability challenges by using the systemic effects of various forms of environmental land rent.Methods. This study uses the methods of comparison, systems analysis, systematization of information, and the monographic method.Results. A generalized scheme for developing competitive advantages in the context of new environmental sustainability challenges and requirements based on the use of the systemic effects of various forms of environmental land rent is presented.Conclusions. The greening of agro-industrial production is a prerequisite for achieving environmental, energy, food, and climate security. Companies that manage to effectively combine sustainability and strategy create value by changing their business model to form a new environmental and social resource associated with factors contributing to business advantage and value creation. The rent system in the agricultural sector expands the concept of land rent. The localization of agricultural rents makes it possible to use systemic effects for increased environmental and social impact, enhancing advantages for the business.
THE USE OF WATERFALL MODEL IN APPLICATION DESIGN WEB-BASED MARYAM DEPARTMENT STORE
Authors: - Indarti , Laraswati Dewi , Supriyatna Adi 
Published: November 2021

Maryam Department Store is a groceries sales business. Cause of high demand for groceries needed by consumers, it also needed to notes the report fast. In increasing the service and ease of transactions, so thats way the system design in selling at Maryam Department Store. The implementation of this information system is expected to be a solution in solving problems and progress at Maryam Department Store. The system design model used is prototyping. The result of this research is a programming application for Maryam Department Store based on Web
Some aspects of the historical development of abuse of right in civil proceedings
Authors: Kurylo Мykola , Kuzmenko Krystyna 
Published: November 2021

The article is the study of certain periods of the development of abuse of right in civil proceedings. It is noted that one can foundthe first references to the abuse of right and its consequences for the legal order as a whole, as well as prototypes of liability for its commission,in the ancient documents of Roman law.
It is substantiated that the Romans, in their understanding of the limits of the exercise of subjective rights, worked the way upfrom giving absolute freedom in its exercise to identifying typical cases of unfair behavior and reasonably prohibiting it in case of intentionsto cause harm to others. Actually, the intentions to cause harm to another person by one’s actions became one of the reasons forthe legislative description by Roman lawyers of the proper use of subjective right and the introduction of targeted restrictions on itsexercise, especially in the field of real estate.The abovesaid is mainly related to the subject of material civil law, however, it also matters for understanding the general contextof the development of the doctrine of abuse of right. The issues of the procedure for the enforcement of law, though not separated frommaterial law, were slightly developed in Roman law. In this regard, the concept of a lawsuit was of particular importance to the Romans.It is significant that even in Roman law, when determining the procedure for adjudicating disputes, special attention was drawnto the possible unfair actions of the litigation parties and methods of dealing with such actions. It was mainly about typical cases of fi -ling a case without merit or objecting to it.The study indicates that in spite of the collapse of the Roman Empire, the main developments and achievements of Romanlawyers in the field of private law were not lost. On the contrary, later they came into widespread use. The evidence of it is, for example,the so-called Italian canonical trial.According to some researches, in the legislation of this period, one can also find the reference to the prohibition of chicanery,that is actions formally meeting legal requirements, but carried out solely for the purpose of causing harm.It is proved that the search for the most effective means of dealing with the abuse of right continued at a new stage in the deve -lopment of the legal system of European states and owing to their successful reception of Roman law. The civil procedural legislationof Germany, France and England, having adopted the Roman idea on preventing the unlawful exercise of subjective right, demonstratedthe main approaches to a possible solution to the problem of abuse of civil procedural rights.
Modern understanding of war strategy and the NATO bloc as one of the security factors
Authors: Bilenchuk Petro , Obikhod Tetyana 
Published: November 2021

Today, globalization is a civilizational process of forming a new world order that is carried out through institutional forms on aglobal scale such as the World Trade Organization (WTO), the Organization for Education, Science and Culture (UNESCO), the NorthAtlantic Alliance (NATO). Ukraine-NATO relations include political, military, law enforcement and economic components. Theinevitable aspect of the evolution of these relations is the transformation of the international security system, the analysis of which is aguarantee of effective cooperation and counteraction to external aggression.The purpose of the article is to analyze the current approach to the military conflict and to consider the conceptual security frameworkfor the formation of Ukraine’s development strategy for reliable protection and successful military development of our state.The history of military associations dives deep into time. The tradition of just war has changed over time, and there has been adesire to impose practical restrictions on war. First of all, strategic leaders, who define large-scale military policy, must control the trainingand preparation of operational plans for national armed forces, deeply rooted in the principles of just war. The worldview of thestrategist is as follows:1. Determination of the stimulus;2. Formulation of interests;3. Evaluation of information;4. Identification of strategic factors;5. Selection of key factors;6. Formulation of strategy.The strategy requires a dynamic approach and the use of the following tools:– change of methods and / or means;– compress the goal;– adjust the strategy;– supplement resources;– reduce the goal and increase funds to achieve it;
– misinformation, bluff;– modification of the purpose.NATO’s Strategic Concept 2010 “Active Participation, Modern Defense” presents NATO’s three most important tasks – collectivedefense, crisis management and security through cooperation.NATO pays special attention to assistance:– in carrying out democratic reforms;– modernizing defense institutions to make them transparent and accountable;– developing the capacity of Partner countries’ armed forces to work with NATO forces;– cope with natural disasters;– in the development of scientific and technical cooperation.Modern means of implementing strategic approaches and the strategic concept of the NATO bloc, as well as the benefits of joi -ning NATO for Ukraine, emphasize the need for a transition to cosmopolitan thinking and legal application in the context of modernpolitical and economical changes and the COVID-19 pandemic.