bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indonesian Rheumatology Association (IRA) Recommendations for Diagnosis and Management of Rheumatoid Arthritis
Authors: Hidayat Rudy , Bagus Putu Putra Suryana  , Linda Kurniaty Wijaya  , Anna Ariane  , Rakhma Yanti Hellmi  , Endy Adnan  , Sumariyono  
Published: August 2021

Introduction: Rheumatoid arthritis (RA) is an autoimmune rheumatic disease which often found in daily practice and requires certain considerations in recognizing clinical appearance also managing the disease as it often causes permanent joint damage, disability, even premature death. This recommendation is expected to become the latest reference for diagnosis and management of RA in Indonesia.
Methods: The steering committee was formed by the Indonesian Rheumatology Association (IRA) to formulate key questions; conduct literature search, selection, and review; then formulate recommendation statements for diagnosis, therapy, and monitoring of RA. Furthermore, the steering committee determined the level of evidence and grades of the recommendations. After that, the level of agreement (LOA) was determined for each item by panelists including rheumatology consultants who have been appointed by IRA to represent Indonesia regions.
Results: The steering committee established 30 recommendations including diagnosis, the role of laboratory and radiology tests, general treatment, the use of glucocorticoids, sDMARD, bDMARD, and tsDMARD. This recommendation also discusses guidelines on monotherapy, combination therapy, treatment strategies (treat-to-target), tapering, and continuous clinical remission. Treatment on co-morbidities and complications are also included in brief.
Conclusion: IRA recommendations regarding the diagnosis and management of RA was made by considering various aspects such as the availability of drugs and supporting facilities, socioeconomic and cultural conditions in Indonesia, as well as the latest research that can be applied to Indonesian population.
Inguinal Lymph Node Squamous Cell Carcinoma of Unknown Primary Site
Authors: Pina L , Sinagra D , Paradedao ME , Juárez MA , Muñoz Pozo F 
Published: August 2021

Resumen

El carcinoma escamoso de piel y mucosas presenta un riesgo potencial de metástasis ganglionares, con la posibilidad de que este suceso preceda la presentación clínica del tumor primario. El objetivo del presente trabajo es describir un caso de linfadenectomía inguinal por metástasis de carcinoma escamoso de origen primario desconocido y realizar una revisión bibliográfica de los casos presentados en la literatura médica.

Se describió el caso de un hombre de 84 años con una tumoración inguinal correspondiente a una neoplasia escamosa, se le realizó una evaluación multidisciplinaria con dermatología, urología y coloproctología, sin encontrar el tumor primario. Se efectuó un vaciamiento inguinal con radioterapia postoperatoria. En la base de datos de Medline informaron solo 49 casos en los últimos 10 años.

Las metástasis inguinales de carcinomas escamosos representan un grupo heterogéneo de neoplasias que pueden originarse a partir de la región anogenital o de territorios cutáneos de la zona perineal, miembros inferiores o parte baja del tronco. El manejo diagnóstico y terapéutico de estas lesiones continúa siendo un desafío al que se debe enfrentar con todas las herramientas disponibles y de forma multidisciplinaria.
ЗДОБУТКИ ТА ПЕРСПЕКТИВИ РОЗВИТКУ ОСВІТИ УКРАЇНИ (ВСЕУКРАЇНСЬКА НАУКОВО-ПРАКТИЧНА КОНФЕРЕНЦІЯ ЗА МІЖНАРОДНОЇ УЧАСТІ У ХАРКОВІ)
Authors: Хомич Лідія Олексіївна , Баніт Ольга Василівна 
Published: August 2021

У статті висвітлено результати роботи Всеукраїнської науково-практичної конференції за міжнародної участі «Освіта України — 30. Здобутки та перспективи», що відбулася в м. Харкові 23-26 червня 2021 р. Наведено ключові аспекти виступів представників Міністерства освіти і науки України, депутатів Верховної Ради України, а також вчених Національної академії педагогічних наук України і польських дослідників на пленарних та секційних засіданнях. Окреслено перспективні напрями подальшого розвитку освіти України в контексті створення Національного технопарку з підвищення якості освіти.
Number is not just an illusion: Discrete numerosity is encoded independently from perceived size
Authors: Adriano Andrea , Girelli Luisa , Rinaldi Luca 
Published: August 2021

AbstractWhile seminal theories suggest that nonsymbolic visual numerosity is mainly extracted from segmented items, more recent views advocate that numerosity cannot be processed independently of nonnumeric continuous features confounded with the numerical set (i.e., such as the density, the convex hull, etc.). To disentangle these accounts, here we employed two different visual illusions presented in isolation or in a merged condition (e.g., combining the effects of the two illusions). In particular, in a number comparison task, we concurrently manipulated both the perceived object segmentation by connecting items with Kanizsa-like illusory lines, and the perceived convex-hull/density of the set by embedding the stimuli in a Ponzo illusion context, keeping constant other low-level features. In Experiment 1, the two illusions were manipulated in a compatible direction (i.e., both triggering numerical underestimation), whereas in Experiment 2 they were manipulated in an incompatible direction (i.e., with the Ponzo illusion triggering numerical overestimation and the Kanizsa illusion numerical underestimation). Results from psychometric functions showed that, in the merged condition, the biases of each illusion summated (i.e., largest underestimation as compared with the conditions in which illusions were presented in isolation) in Experiment 1, while they averaged and competed against each other in Experiment 2. These findings suggest that discrete nonsymbolic numerosity can be extracted independently from continuous magnitudes. They also point to the need of more comprehensive theoretical views accounting for the operations by which both discrete elements and continuous variables are computed and integrated by the visual system.
Dust Production of Interstellar Comet 2I/Borisov Throughout Perihelion
Authors: Clements Tiffany D. 
Published: August 2021

Abstract
The recently discovered comet 2I/Borisov quickly became a prime target for comet observers during its perihelion approach in 2019 December, after it was discovered to be the first comet of interstellar origin. We present our observations and measurements of the dust production between 2019 October, when the interstellar comet became bright enough for small aperture telescopes, and 2020 January, when the comet entered the plane of the Milky Way. We observed the comet for 24 nights using three telescopes in the public iTelescope network. The telescopes spanned both the Northern and Southern hemispheres, were of similar aperture size (0.43–0.51 m), and employed a Johnson–Cousins R
C filter. Using these data, we measure an A(0°)f
ρ range of 94 ± 14 to 139 ± 34 cm, a dust production rate Q
dust range of 11.2 ± 4.4 to 16.4 ± 7.3 kg s−1, and a dust-brightness profile-parameter range of −0.95 ± 0.11 to −1.81 ± 0.20 for the interstellar comet. This work revealed low dust production rates from the comet that remained consistent throughout its apparition, with no notable brightening or increase in dust production throughout the observing campaign.
Resolving Complex Inner X-Ray Structure of the Gravitationally Lensed AGN MG B2016+112
Authors: Schwartz Daniel , Spingola Cristiana , Barnacka Anna 
Published: August 2021

Abstract
We use a Chandra X-ray observation of the gravitationally lensed system MG B2016+112 at z = 3.273 to elucidate the presence of at least two X-ray sources. We find that these sources are consistent with the very long baseline interferometry (VLBI) components measured by Spingola, which are separated by ∼200 pc. Their intrinsic 0.5–7 keV source frame luminosities are 1.5 × 1043 and 1.8 × 1044 erg s−1, respectively. Most likely this system contains a dual active galactic nucleus (AGN), but we are possibly detecting an AGN plus a parsec-scale X-ray jet, the latter lying in a region at very high magnification. The quadruply lensed X-ray source is within ±40 pc (1σ) of its VLBI counterpart. Using a gravitational lens as a telescope, and a novel statistical application, we have achieved unprecedented accuracy for measuring metric distances at such large redshifts in X-ray astronomy. This is tens of mas if the source is located close to the caustics, while it is of hundreds of mas if the source is in a region at lower amplification. The present demonstration of this approach has implications for future X-ray investigations of large numbers of lensed systems.
The Formation and Lifetime of Outflows in a Solar Active Region
Authors: Brooks David H. , Harra Louise , Bale Stuart D. , Barczynski Krzysztof , Mandrini Cristina , Polito Vanessa , Warren Harry P. 
Published: August 2021

Abstract
Active regions are thought to be one contributor to the slow solar wind. Upflows in EUV coronal spectral lines are routinely observed at their boundaries, and provide the most direct way for upflowing material to escape into the heliosphere. The mechanisms that form and drive these upflows, however, remain to be fully characterized. It is unclear how quickly they form, or how long they exist during their lifetimes. They could be initiated low in the atmosphere during magnetic flux emergence, or as a response to processes occurring high in the corona when the active region is fully developed. On 2019 March 31 a simple bipolar active region (AR 12737) emerged and upflows developed on each side. We used observations from Hinode, SDO, IRIS, and Parker Solar Probe (PSP) to investigate the formation and development of the upflows from the eastern side. We used the spectroscopic data to detect the upflow, and then used the imaging data to try to trace its signature back to earlier in the active region emergence phase. We find that the upflow forms quickly, low down in the atmosphere, and that its initiation appears associated with a small field-opening eruption and the onset of a radio noise storm detected by PSP. We also confirmed that the upflows existed for the vast majority of the time the active region was observed. These results suggest that the contribution to the solar wind occurs even when the region is small, and continues for most of its lifetime.
Social Determinants, Health Literacy, and Disparities: Intersections and Controversies
Authors: Schillinger Dean 
Published: August 2021

This article synthesizes what is known about the relationship between social disadvantage and measures of health literacy (HL), and reviews the research examining whether low HL is an explanatory factor connecting social disadvantage, health outcomes, and health disparities. Written from a United States perspective, this article offers a novel conceptual framework that presents how the social determinants of health might interact with HL to result in health disparities. The framework articulates relationships that reflect public health pathways and health care pathways, which include their related health literacies. The article continues with several cautionary statements based on the inherent limitations of current HL research, including problems and concerns specific to the attribution of HL as an explanatory factor for extant socioeconomic and racial/ethnic health disparities. The article closes with recommendations regarding future research directions.

[
HLRP: Health Literacy Research and Practice
. 2021;5(3):e233–e243.]

Plain Language Summary:
Socially disadvantaged populations have worse health and health literacy compared to privileged populations. Scientists, health care providers, and policymakers are interested in the possible role health literacy plays in explaining health differences. The article reviews our current understandings of whether and how population characteristics and related exposures to risk interact with low health literacy to generate worse health to inform interventions.
Assessing Teach-Back Utilization in a Downtown Medical Center
Authors: Komondor Karen , Choudhury Ryan 
Published: August 2021

Background:
The St. Vincent Charity Medical Center's Patient and Family Education Policy directs staff to provide patients with easy-to-understand written and verbal communication. This includes using plain language and Teach-Back. Teach-Back—or asking patients to explain in their own words what they have learned—is a best practice that health care professionals use to ensure patient understanding. The effective use of plain language is key to using Teach-Back successfully. From random audits, we could assess whether staff were documenting their use of Teach-Back. We had not, however, ascertained whether that documentation was a true account of the use of Teach-Back.

Brief description of activity:
We created a three-part project to (1) assess staff knowledge and use of Teach-Back, (2) assess and address barriers to use of Teach-Back, and 3) assess patients' recall of their providers using Teach-Back.

Implementation:
Internal medicine resident physicians (hereafter termed “residents”) and nurses completed an anonymous, online survey regarding their experience with Teach-Back. After vetting, these responses were integrated into mandatory provider training. Focusing on health literacy and Teach-Back, the training addressed barriers, reinforced positive experiences, and tailored practice encounters to patients. We then randomly surveyed inpatients to assess their recall of their providers using Teach-Back.

Results:
The majority (96.3%) of providers indicated that Teach-Back should be used frequently. Only 79.9%, however, reported using Teach-Back. Providers regarded Teach-Back as important and rated their confidence level as high. Providers also reported barriers to Teach-Back. Of the 135 patients surveyed, 46% recalled their providers using this method.

Lessons learned:

We note a gap between providers' self-reported use of Teach-Back and patients' recall of their providers using it. Providers may be overstating their utilization rate. The survey, further, assessed patients at random points in their hospital stays, to include those who had not yet received Teach-Back education. These factors could contribute to the observed discrepancy. Most notably, results confirmed our position that regular provider training helps address barriers and misconceptions about Teach-Back.

[
HLRP: Health Literacy Research and Practice
. 2021;5(3):e226–e232.]

Plain Language Summary:
Our Health Literacy Institute was created in 2007 after receiving a grant to institutionalize health literacy across the continuum of patient care. Health literacy refers to a person's ability to obtain, understand, and process basic information, which empowers them to make appropriate health decisions.
Exploiting Cloud Computing and Web Services to Achieve Data Consistency, Availability, and Partition Tolerance in the Large-Scale Pervasive Systems
Authors: Fadelelmoula Ashraf Ahmed 
Published: August 2021

This article presents a new comprehensive approach to realize a sufficient trade-off between the CAP properties (i.e., consistency, availability, and partition tolerance) in the large-scale pervasive information systems. To achieve these critical properties, the capabilities of both cloud computing and web services were exploited in developing the components of the proposed approach. These components include a cloud-based replication architecture for ensuring high data availability and achieving partition tolerance, a web services-based middleware for maintaining the eventual consistency, and a data caching scheme to enable the mobile computing elements to conduct update transactions during the disconnection periods. The evaluation of the performance aspects revealed that the proposed approach is able to achieve a load balance, lower propagation delay, and higher cache hit ratio, as compared to other baseline approaches.
Electric Controls Technology: The Role in Future Subsea Systems
Authors: Moe Sigurd , Monsson Olav S. , Rokne Øyvind , Kumar Ajith , Johansen Christina 
Published: August 2021

Abstract
This paper prepared for 2018 OTC Offshore Asia explores the current history of electrically driven functionality for subsea production systems.
It is expected that co-existence of hybrid electrohydraulic and all-electric functionality will dominate the market for subsea tree and manifold control short term. Electric choke and manifold valve actuation offer many advantages as proved successfully during the last 16 years, e.g. related to modularity and flexibility, with zero discharge, with high operational speed and high positioning accuracy, along with CAPEX and OPEX benefits. Performance of systems such as Statoil's Asgard Subsea Gas Compressor is a game changer that will make all-electric valve control base case also for future subsea processing plants.
Reliability & Availability concerns were the major concerns by many operators for not switching to all-electric technology. The excellent reliability of trickle charged batteries in subsea systems, combined with modern safety electronics eliminate the traditional actuator spring as failsafe mechanism power source. All of this has simplified the equipment, reduced the size, and enables continuous equipment status monitoring.
Competitive all-electric systems are expected to be introduced in stages, starting with infill wells. This will eliminate the risk of new technology for the best business cases, being long distance gas fields, water injectors and deep water systems.
Subsea all-electric solutions benefit from general technology developments in other industries. Full utilization is however slow in the subsea market, hampered by current rules and regulations, risk aspects and conservative mindsets. All-electric solutions need Champions and a continued successful staged development initiatives to realize their full potential for significantly reducing subsea field development capital and operational cost.
A Conformational Change of Complement C5 Is Required for Thrombin-Mediated Cleavage, Revealed by a Novel Ex Vivo Human Whole Blood Model Preserving Full Thrombin Activity
Authors: Nilsson Per H , Johnson Christina , Quach Quang Huy , Macpherson Alex , Durrant Oliver , Pischke Soeren E , Fure Hilde , Landsem Anne , Bergseth Grethe , Schjalm Camilla , Haugaard-Kedström Linda M , Huber-Lang Markus , van den Elsen Jean , Brekke Ole-Lars , Mollnes Tom Eirik 
Published: August 2021

Abstract
Thrombin activation of C5 connects thrombosis to inflammation. Complement research in whole blood ex vivo necessitates anticoagulation, which potentially interferes with the inflammatory modulation by thrombin. We challenged the concept of thrombin as an activator of native C5 by analyzing complement activation and C5 cleavage in human whole blood anticoagulated with Gly-Pro-Arg-Pro (GPRP), a peptide targeting fibrin polymerization downstream of thrombin, allowing complete endogenous thrombin generation. GPRP dose-dependently inhibited coagulation but allowed for platelet activation in accordance with thrombin generation. Spontaneous and bacterial-induced complement activation by Escherichia coli and Staphylococcus aureus, analyzed at the level of C3 and C5, were similar in blood anticoagulated with GPRP and the thrombin inhibitor lepirudin. In the GPRP model, endogenous thrombin, even at supra-physiologic concentrations, did not cleave native C5, despite efficiently cleaving commercially sourced purified C5 protein, both in buffer and when added to C5-deficient serum. In normal serum, only exogenously added, commercially sourced C5 was cleaved, whereas the native plasma C5 remained intact. Crucially, affinity-purified C5, eluted under mild conditions using an MgCl2 solution, was not cleaved by thrombin. Acidification of plasma to pH ≤ 6.8 by hydrochloric or lactic acid induced a C5 antigenic change, nonreversible by pH neutralization, that permitted cleavage by thrombin. Circular dichroism on purified C5 confirmed the structural change during acidification. Thus, we propose that pH-induced conformational change allows thrombin-mediated cleavage of C5 and that, contrary to previous reports, thrombin does not cleave plasma C5 in its native form, suggesting that thrombin cleavage of C5 may be restricted to certain pathophysiological conditions.
Higher-Order Lookup Table Masking in Essentially Constant Memory
Authors: Valiveti Annapurna , Vivek Srinivas 
Published: August 2021

Masking using randomised lookup tables is a popular countermeasure for side-channel attacks, particularly at small masking orders. An advantage of this class of countermeasures for masking S-boxes compared to ISW-based masking is that it supports pre-processing and thus significantly reducing the amount of computation to be done after the unmasked inputs are available. Indeed, the “online” computation can be as fast as just a table lookup. But the size of the randomised lookup table increases linearly with the masking order, and hence the RAM memory required to store pre-processed tables becomes infeasible for higher masking orders. Hence demonstrating the feasibility of full pre-processing of higher-order lookup table-based masking schemes on resource-constrained devices has remained an open problem.
In this work, we solve the above problem by implementing a higher-order lookup table-based scheme using an amount of RAM memory that is essentially independent of the masking order. More concretely, we reduce the amount of RAM memory needed for the table-based scheme of Coron et al. (TCHES 2018) approximately by a factor equal to the number of shares. Our technique is based upon the use of pseudorandom number generator (PRG) to minimise the randomness complexity of ISW-based masking schemes proposed by Ishai et al. (ICALP 2013) and Coron et al. (Eurocrypt 2020). Hence we show that for lookup table-based masking schemes, the use of a PRG not only reduces the randomness complexity (now logarithmic in the size of the S-box) but also the memory complexity, and without any significant increase in the overall running time. We have implemented in software the higher-order table-based masking scheme of Coron et al. (TCHES 2018) at tenth order with full pre-processing of a single execution of all the AES S-boxes on a ARM Cortex-M4 device that has 256 KB RAM memory. Our technique requires only 41.2 KB of RAM memory, whereas the original scheme would have needed 440 KB. Moreover, our 8-bit implementation results demonstrate that the online execution time of our variant is about 1.5 times faster compared to the 8-bit bitsliced masked implementation of AES-128.