bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increases in Psychological Flexibility Mediate Relationship Between Acute Psychedelic Effects and Decreases in Racial Trauma Symptoms Among People of Color
Authors: Davis Alan K. , Xin Yitong , Sepeda Nathan D. , Garcia-Romeu Albert , Williams Monnica T. 
Published: August 2021

Background Previous research showed acute psychedelic effects were associated with decreases in racial trauma (RT) symptoms among black, indigenous, and people of color (BIPOC). Among samples comprised primarily of white participants, positive outcomes of psychedelic experiences have been mediated by increases in psychological flexibility. Therefore, we examined whether changes in psychological flexibility from before to after a psychedelic experience mediated the relationship between acute psychedelic effects and changes in RT symptoms among BIPOC. Methods This cross-sectional online survey study included 313 BIPOC (mean age = 33.1; SD = 11.2; female = 57%). A multiple linear regression analysis was used to examine the association between acute psychedelic effects and decreases in RT symptoms in a nonclinical setting; a path analysis was used to explore whether changes in psychological flexibility mediated this relationship. Results Acute insight and challenging effects were significantly ( p < .001) associated with decreases in RT symptoms following a psychedelic experience. Increases in psychological flexibility partially mediated relationships between greater intensity of psychological insight and less intensity of challenging experiences and decreases in RT symptoms ( ps<.001). Conclusion This research suggests psychedelics confer potential benefits in decreasing RT symptoms among BIPOC and psychological flexibility may be an important mediator of these effects. Future research should test this hypothesis in a longitudinal clinical trial among BIPOC.
In Type 2 Diabetes Mellitus Patients, the Atherogenic Index of Plasma as a Marker of Coronary Artery Diseases
Authors: Al-Shaer Muhammed Hossam , Elzaky Manar Mostafa , Farag El Sayed Mohamed , Saad Mostafa Osama Mohamed 
Published: August 2021

One-third of all deaths globally are caused by cardiovascular disease (CVD), and this percentage is predicted to climb as CVD risk factors become more widespread. Primary prevention of risk factors is the most fundamental duty in dealing with the CVD epidemic. The link between atherogenic index of plasma (AIP) and other CVD risks among university workers was investigated among study participants in order to demonstrate that AIP, not lipid profile, is a better predictor of CVDs. They discovered a link between AIP and CVD risk variables (body mass index, visceral fat, body fat, total cholesterol, low density lipoprotein cholesterol, triglyceride, glucose, and high density lipoprotein cholesterol) in people with type 2 diabetes. This comparative study was carried out in Cardiology Department, Zagazig University Hospitals. This study included 140 type 2 diabetes mellitus patients. They were classified into 2 main groups: Group 1: 70 patients with type 2 diabetes who had coronary artery disease (CAD). Group (2): 70 type 2 diabetes individuals with no indicators of CAD (admitted complaining of symptoms of angina or CA showing no significant stenotic lesions). Regarding study explained it has showed that AIP outperforms standard lipid indicators in predicting the likelihood ofdeveloping CADs in people with type 2 diabetes. In addition, the value of AIP in diabetic and prediabetic patients for predicting future CVD is being investigated. They came to the conclusion that AIP is an excellent predictor of future CVD in those with diabetes and those who are prediabetic.
Lateral Retinaculum Lengthening and Medial Patellofemoral Ligament Reconstruction With Adductor Sling Technique
Authors: Martinez-Cano Juan Pablo , Gomez-Sierra Maria Antonia , Castelo Andreu , Mejía Fernando Manuel 
Published: August 2021

Background: There are multiple ways of reconstructing the medial patellofemoral ligament (MPFL), including dynamic techniques that fix the graft to the adductor magnus tendon. We present this technique associated to an increasingly common surgery used as adjuvant in some patients with patellar instability, lateral retinaculum lengthening. Indications: Recurrent patellar dislocation with medial laxity and lateral tightness/lateral tilt. Technique Description: This is double bundle MPFL reconstruction with anterior tibialis tendon allograft. Both autograft or allograft may be used, with a minimum length of 15 cm. The graft is fixed to the proximal third of the patella, passing as a sling under the adductor magnus tendon where it is fixed with sutures and returns to the patella. The patellar fixation includes a 10 to 15 mm deep and 4 to 4.5 mm diameter tunnel in the proximal third with suture stitches to the soft tissues in the entrance of the tunnel, plus an anterior periostic tunnel for the second bundle in the proximal third of the patella fixed with suture stitches. Meanwhile, the lateral retinaculum is incised longitudinally into a superficial and deep layer, in order to lengthen it the desired length. Results: The expected outcome of the procedure is to have a stable patellofemoral joint, with patients that gain the lost function and may return to sport without recurrence of patellar dislocation. Discussion/Conclusion: This is a simple, cheap, and reproducible technique that corrects both medial laxity and lateral tightness for patients with recurrent patellar dislocation.
The mineralogy of the historical Mochalin Log REE deposit, South Urals, Russia. Part IV. Alexkuznetsovite-(La), La2Mn(CO3)(Si2O7), alexkuznetsovite-(Ce), Ce2Mn(CO3)(Si2O7) and biraite-(La), La2Fe2+(CO3)(Si2O7), three new isostructural minerals and a definition of the biraite group
Authors: Kasatkin Anatoly V. , Zubkova Natalia V. , Pekov Igor V. , Chukanov Nikita V. , Škoda Radek , Agakhanov Atali A. , Belakovskiy Dmitriy I. , Britvin Sergey N. , Yu. Pushcharovsky Dmitry 
Published: August 2021

AbstractThree new isostructural minerals, alexkuznetsovite-(La), ideally La2Mn(CO3)(Si2O7), alexkuznetsovite-(Ce) Ce2Mn(CO3)(Si2O7) and biraite-(La) La2Fe2+(CO3)(Si2O7), were discovered in polymineralic nodules from the Mochalin Log REE deposit, South Urals, Russia. The new minerals form anhedral grains up to 0.3 mm × 0.4 mm [alexkuznetsovite-(La)], 0.5 mm × 0.9 mm [alexkuznetsovite-(Ce)] and 0.2 mm × 1.2 mm [biraite-(La)] embedded in granular aggregates consisting of different REE minerals [allanite-(Ce)/-(La), bastnäsite-(Ce)/-(La), fluorbritholite-(Ce), perbøeite-(Ce)/-(La), percleveite-(Ce)/-(La) and törnebohmite-(Ce)/-(La)]. All three new species are brown to dark brown, translucent in thin fragments, with white streak, vitreous lustre and Mohs’ hardness of ~5. Dcalc = 4.713 [alexkuznetsovite-(La)], 4.687 [alexkuznetsovite-(Ce)] and 4.682 [biraite-La)] g⋅cm–3. Their empirical formulae, calculated on the basis of 2 Si and 10 O apfu, are: alexkuznetsovite-(La): (La0.98Ce0.89Nd0.10Pr0.05)Σ2.02Mn2+0.50Fe2+0.29Ca0.12Mg0.03(CO3)0.94(HCO3)0.06 (Si2O7); alexkuznetsovite-(Ce): (Ce0.96La0.78Nd0.16Pr0.07)Σ1.97Th0.01Mn2+0.50Fe2+0.33Ca0.14Mg0.02(CO3)0.93(HCO3)0.07(Si2O7); and biraite-(La): (La0.95Ce0.87Nd0.08Pr0.04)Σ1.94Th0.01Ca0.12Fe2+0.44Mn2+0.38Mg0.07(CO3)0.88(HCO3)0.12(Si2O7). The new minerals are monoclinic, P21/c and Z = 4. The unit-cell parameters of alexkuznetsovite-(La)/alexkuznetsovite-(Ce)/biraite-(La) are: a = 6.5642(3)/6.5764(4)/6.5660(10), b = 6.7689(3)/6.7685(4)/6.7666(11), c = 18.7213(10)/18.7493(15)/18.698(3) Å, β = 108.684(6)/108.672(8)/108.952(16)° and V = 788.00(7)/790.66(10)/785.7(2) Å3. The crystal structures are solved from single-crystal X-ray diffraction data; R = 0.0628 [alexkuznetsovite-(La)], 0.0589 [alexkuznetsovite-(Ce)] and 0.1193 [biraite-(La)]. A new biraite group is defined; it includes isostructural biraite-(Ce) and the three new minerals described herein. The rootname alexkuznetsovite is given in honour of the Russian mineral collector Alexey M. Kuznetsov (born 1962) who provided samples in which all three new minerals were found. The Levinson's suffix-modifier -(La) or -(Ce) indicates the predominance of La or Ce among REE in the mineral. Biraite-(La) is named as an analogue of biraite-(Ce) with La prevailing among REE.
Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma in Taiwan
Authors: Hsu Ming-Hung , Wang Wen-Lun , Chen Tzu-Haw , Tai Chi-Ming , Wang Hsiu-Po , Lee Ching-Tai 
Published: August 2021

Abstract
Background
Endoscopic submucosal dissection (ESD) is gradually turning into the standard treatment for superficial esophageal squamous cell carcinoma (SESCC), however, the long-term outcomes have hardly ever been reported outside Japan.

Method
We consecutively recruited patients with SESCC who had received ESD treatment at E-Da Hospital. The demographics, pathological characteristics, and Lugol staining background pattern (type A or B: none or < 10 small Lugol-voiding lesions [LVLs]; type C or D: > 10 small or multiform LVLs) were collected, and then correlated to outcomes and survival.

Results
Total of 229 lesions were enrolled and the mean lesion size was 3.28 ± 1.69 (range 1–10) cm. 72% of the lesions had a type C-D Lugol staining background pattern. After ESD, the en bloc and R0 resection rates were 93.9% and 83.5%, respectively. Forty-nine subjects developed complications, including six (2.6%) with major bleeding, two (0.9%) with perforation, and 41 (17.9%) with strictures. Pathological staging showed that 19 cases had deep submucosal cancer invasion and subsequently received adjuvant therapies. During a mean follow-up period of 52.6 (range 3–146) months, 41 patients developed metachronous recurrence. The patients with a type C-D Lugol staining background pattern were associated with a higher risk of recurrence than those with few LVLs (log-rank P = 0.019). The 10-year survival rate was more than 90%, and only eight patients died of ESCC.

Conclusion
ESD has excellent long-term outcomes but a high risk of metachronous recurrence. The Lugol staining pattern over the background mucosa could offer the risk stratification of metachronous recurrence.
Kikuchi-Fujimoto disease presenting in a patient with SARS-CoV-2: a case report
Authors: Racette Samuel D. , Alexiev Borislav A. , Angarone Michael P. , Bhasin Ajay , Lima Kaitlin , Jennings Lawrence J. , Balasubramanian Senthil , Matsuoka Akihiro J. 
Published: August 2021

Abstract
Background
We present a yet to be described association of SARS-CoV-2 infection with Kikuchi-Fujimoto disease.

Case presentation
A 32-year-old physician with history of SARS-CoV-2 infection presented to the emergency department with 2 weeks of fever, chills, and right sided cervical lymphadenopathy. He was treated empirically for presumed folliculitis with worsening of symptoms leading to repeat presentation to the emergency department.
Extensive workup was unrevealing of an infectious cause and needle biopsy of the lesion was unrevealing. An excisional lymph node biopsy revealed follicular hyperplasia with necrotic foci showing abundance of histiocytes at the edge of necrosis with CD8 predominance of T-cells. Final diagnosis was deemed to be Kikuchi-Fujimoto disease. Antibiotic therapy was discontinued, and the patient’s symptoms resolved with steroid therapy and expectant management.

Conclusions
This is the first report of a patient developing Kikuchi-Fujimoto disease following SARS-CoV-2 infection. Clinicians should be aware of Kikuchi-Fujimoto disease as a possibility when approaching patients with hyper-inflammatory states who present with cervical lymphadenopathy.
Advance care planning preferences in Chinese nursing home residents: results from two cross-sectional studies in Hong Kong and Taiwan
Authors: Xu Xinyi , Tu Shu-Wen , Lin Chia-Chin 
Published: August 2021

Abstract
Background
The proportion of hospital deaths has declined in the past few decades, while the proportions of nursing home deaths have increased. This trend of increasing deaths in long-term care facilities underlines the importance of improving end-of-life care provisions in these settings to meet individual preferences and needs. Under these circumstances, a comprehensive understanding of end-of-life care preferences in local nursing home residents can help healthcare professionals and policymakers develop strategies to increase the advance directive completion rate and quality of care. This study aimed to explore and compare advance directive and end-of-life care preferences of nursing home residents in Hong Kong and Taiwan.

Methods
A structured questionnaire was developed by the research team to investigate advance directive and end-of-life care preferences in older Chinese nursing home residents. Nursing home residents with frail or pre-frail status and over the age of 64 were invited to participate in the study, and information on demographics, functional status, advance directive experiences, and end-of-life care expectations was collected through questionnaire interviews.

Results
A total of 325 eligible participants from 32 facilities completed the survey, including 238 older residents in Hong Kong and 87 in Taiwan. A significantly lower proportion of the Hong Kong residents had completed an advance directive compared with the Taiwanese (3 vs. 13%, p = 0.001). Among participants who did not have an advance directive, 46% of the Taiwanese participants said they would consider completing one in the future, compared with 20% of the Hong Kong participants (p < 0.001). A total of 79% of the Hong Kong participants and 80% of the Taiwanese participants responded that prolonging life in the given hypothetical dying scenario was “not important” (p = 0.76). Only 14% of participants in Hong Kong and 18% of participants in Taiwan reported prior occurrence of end-of-life care discussions with family members or health professionals (p = 0.37).

Conclusions
This paper adds evidence in support of improving end-of-life communication and the advance directive completion rate in nursing homes in Hong Kong and Taiwan. Further research is necessary to explore cross-cultural differences in end-of-life preferences and its applications in predicting decision-making and the quality of end-of-life care.
Cost drivers in the pharmacological treatment of interstitial lung disease
Authors: Maqhuzu Phillen Nozibuyiso , Kreuter Michael , Bahmer Thomas , Kahn Nicolas , Claussen Martin , Holle Rolf , Schwarzkopf Larissa 
Published: August 2021

AbstractIntroductionTreatments of interstitial lung diseases (ILDs) mainly focus on disease stabilization and relief of symptoms by managing inflammation or suppressing fibrosis by (in part costly) drugs. To highlight economic burden of drug treatment in different ILD-subtypes we assessed cost trends and therewith-associated drivers.MethodsUsing data from the German, observational HILDA study we estimated adjusted mean medication costs over 36-month intervals using one- and two-part Generalized Estimating Equation (GEE) regression models with a gamma distribution and log link. Next, we determined factors associated with costs.ResultsIn Idiopathic pulmonary fibrosis (IPF) mean per capita medication costs increased from €1442 before to €11,000€ at the end of study. In non-IPF subtypes, the increase took place at much lower level. Mean per capita ILD-specific medication costs at the end of the study ranged between €487 (other ILD) and €9142 (IPF). At baseline, higher FVC %predicted values were associated with lower medication costs in IPF (−9%) and sarcoidosis (−1%). During follow up higher comorbidity burden escalated costs in progressive fibrosing ILD (PF-ILD) (+52%), sarcoidosis (+60%) and other ILDs (+24%). The effect of disease duration was not uniform, with cost savings in PF-ILD (−8%) and sarcoidosis (−6%), but increased spending in IPF (+11%).ConclusionPharmacological management of ILD, in particular of IPF imposes a substantial economic burden on the healthcare system. Strategies to reduce comorbidity burden and early treatment may reduce the impact of ILDs on the healthcare system.
The N-terminus of Lactobacillus amylovorus feruloyl esterase plays an important role in its secretion by Lactobacillus plantarum and Escherichia coli
Authors: Xu Zhenshang , Zhang Rongling , Wang Ting , Kong Jian 
Published: August 2021

Abstract
Background
Feruloyl esterase is a multifunctional esterase with potential industrial applications. In the present study, we found the Lactobacillus amylovorus feruloyl esterase (FaeLam) could be secreted by L. plantarum and Escherichia coli. However, no signal peptide was detected in this protein as predicted by SignalP-5.0. Therefore, experiments were carried out to propose an explanation for the extracellular release of FaeLam.

Results
Here, we identified that the FaeLam could be secreted to the culture medium of L. plantarum CGMCC6888 and E. coli DH5α, respectively. To exclude the possibility that FaeLam secretion was caused by its hydrolytic activity on the cell membrane, the inactive FaeLamS106A was constructed and it could still be secreted out of L. plantarum and E. coli cells. Furthermore, the truncated version of the FaeLam without the N-terminal residues was constructed and demonstrated the importance of the 20 amino acids of N-terminus (N20) on FaeLam secretion. In addition, fusion of heterologous proteins with N20 or FaeLam could carry the target protein out of the cells. These results indicated the N-terminus of FaeLam played the key role in the export process.

Conclusions
We proved the N-terminus of L. amylovorus FaeLam plays an important role in its secretion by L. plantarum and E. coli. To our best knowledge, this is the first reported protein which can be secreted out of the cells of both Gram-positive and Gram-negative bacteria. Furthermore, the results of this study may provide a new method for protein secretion in L. plantarum and E. coli through fusion the target protein to N20 of FaeLam.
Short report: Performance evaluation of the Idylla™ KRAS and EGFR mutation tests on paraffin-embedded cytological NSCLC samples
Authors: Offerman Saskia , Prinsen Clemens F. , Knol Ageeth , Methorst Natalie , Kamphorst Jeanette , Niemantsverdriet Maarten 
Published: August 2021

Abstract
Background
Quick and reliable testing of EGFR and KRAS is needed in non-small cell lung cancer (NSCLC) to ensure optimal decision-making for targeted therapy. The Idylla™ platform was designed for Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections but recently several studies were published that evaluated its potential for cytological specimens. This study aimed to validate the Idylla™ platform for the detection of EGFR/KRAS mutations in cytological NSCLC samples prepared as cytoblocks using AGAR and paraffin embedding.

Material and methods
The KRAS Idylla™ test were performed on 11 specimens with a known KRAS mutation. The EGFR Idylla™ test was performed on 18 specimens with a known primary EGFR mutation and 7 specimens with a primary EGFR-EGFR T790M resistance mutation combination.

Results
Concordant KRAS and primary EGFR mutations were detected for both KRAS and primary EGFR mutations. Samples with a total CQ value of < 26 could be considered negative. Samples with a total CQ value of > 26 could not be assessed (probability of false-negative). In specimens with a primary EGFR-EGFR T790M resistance mutation combination, 5/7 cases were not concordant.

Conclusion
Our results confirm the conclusion of recent reports that the Idylla™EGFR assay is not suitable in a resistance to EGFR TKI setting, also not in our cytological NSCLC samples prepared as cytoblocks using AGAR and paraffin embedding. KRAS and primary EGFR mutations were detected using the Idylla™ assays in virtually all cytological NSCLC samples. This analysis was rapid and time-saving compared to other mutation detection assays and may be useful if the amount of material is insufficient to perform a full set of molecular tests.
How does urbanization affect perceptions and traditional knowledge of medicinal plants?
Authors: Arjona-García Cecilia , Blancas José , Beltrán-Rodríguez Leonardo , López Binnqüist Citlalli , Colín Bahena Hortensia , Moreno-Calles Ana Isabel , Sierra-Huelsz José Antonio , López-Medellín Xavier 
Published: August 2021

AbstractBackgroundThe use and knowledge of medicinal plants play an essential role in community health in rural Mexico. Medicinal plants are part of the local heritage and provide a source of economic income. Nevertheless, knowledge of their use has declined due to factors like accelerated urbanization. Some authors have proposed that by reducing natural spaces, urbanization generates changes that impact the recognition, use, and management of natural resources. Here, we evaluate how urbanization affects the knowledge, use, and perception of medicinal plants in a Biosphere Reserve in Mexico.MethodsUsing a mixed methodology including quantitative and qualitative analyses, we generated a list of medicinal plants, methods of preparation, prevalence of illness, and use in two communities with different degrees of urbanization.ResultsA total of 217 medicinal plants were identified. The more urbanized community had greater knowledge of, and used, a larger number of introduced plant species, while the less urbanized community used and had more knowledge about wild plants. One of the factors explaining these differences was occupation, with people who work outdoors showing greater knowledge of wild plants.ConclusionsUrbanization can lead to a loss of knowledge of the use and management of local wild species, with implications for the conservation of biocultural heritage. Substitution of native medicinal plants by introduced species shows disinterest and disuse in the local medicinal flora, which could be reflected in their ecosystems.
Collaboration between emergency physicians and citizen responders in out-of-hospital cardiac arrest resuscitation
Authors: Jellestad Anne-Sofie Linde , Folke Fredrik , Molin Rune , Lyngby Rasmus Meyer , Hansen Carolina Malta , Andelius Linn 
Published: August 2021

AbstractBackgroundCitizen responder programmes dispatch volunteer citizens to initiate resuscitation in nearby out-of-hospital cardiac arrests (OHCA) before the Emergency Medical Services (EMS) arrival. Little is known about the interaction between citizen responders and EMS personnel during the resuscitation attempt. In the Capital Region of Denmark, emergency physicians are dispatched to all suspected OHCAs. The aim of this study was to evaluate how emergency physicians perceived the collaboration with citizen responders during resuscitation attempts.MethodThis cross-sectional study was conducted through an online questionnaire. It included all 65 emergency physicians at Copenhagen EMS between June 9 and December 13, 2019 (catchment area 1.8 million). The questionnaire examined how emergency physicians perceived the interaction with citizen responders at the scene of OHCA (use of citizen responders before and after EMS arrival, citizen responders’ skills in cardiopulmonary resuscitation (CPR), and challenges in this setting).ResultsThe response rate was 87.7% (57/65). Nearly all emergency physicians (93.0%) had interacted with a citizen responder at least once. Of those 92.5%(n = 49) considered it relevant to activate citizen responders to OHCA resuscitation, and 67.9%(n = 36) reported the collaboration as helpful. When citizen responders arrived before EMS, 75.5%(n = 40) of the physicians continued to use citizen responders to assist with CPR or to carry equipment. Most (84.9%,n = 45) stated that citizen responders had the necessary skills to perform CPR. Challenges in the collaboration were described by 20.7%(n = 11) of the emergency physicians and included citizen responders being mistaken for relatives, time-consuming communication, or crowding problems during resuscitation.ConclusionEmergency physicians perceived the collaboration with citizen responders as valuable, not only for delivery of CPR, but were also considered an extra helpful resource providing non-CPR related tasks such as directing the EMS to the arrest location, carrying equipment and taking care of relatives.