bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ridge energy for thin nematic polymer networks
Authors: Pedrini Andrea , Virga Epifanio G. 
Published: February 2021

AbstractMinimizing the elastic free energy of a thin sheet of nematic polymer network among smooth isometric immersions is the strategy purported by the mainstream theory. In this paper, we broaden the class of admissible spontaneous deformations: we considerridgedisometric immersions, which can cause a sharp ridge in the immersed surfaces. We propose a model to compute the extra energy distributed along such ridges. This energy comes from bending; it is shown under what circumstances it scales quadratically with the sheet’s thickness, falling just in between stretching and bending energies. We put our theory to the test by studying the spontaneous deformation of a disk on which a radial hedgehog was imprinted at the time of crosslinking. We predict the number of folds that develop in terms of the degree of order induced in the material by external agents (such as heat and illumination).Graphic Abstract
Monotonicity and symmetry of positive solutions to fractional p-Laplacian equation
Authors: Dai Wei , Liu Zhao , Wang Pengyan 
Published: February 2021

In this paper, we are concerned with the following Dirichlet problem for nonlinear equations involving the fractional [Formula: see text]-Laplacian: [Formula: see text] where [Formula: see text] is a bounded or an unbounded domain which is convex in [Formula: see text]-direction, and [Formula: see text] is the fractional [Formula: see text]-Laplacian operator defined by [Formula: see text] Under some mild assumptions on the nonlinearity [Formula: see text], we establish the monotonicity and symmetry of positive solutions to the nonlinear equations involving the fractional [Formula: see text]-Laplacian in both bounded and unbounded domains. Our results are extensions of Chen and Li [Maximum principles for the fractional p-Laplacian and symmetry of solutions, Adv. Math. 335 (2018) 735–758] and Cheng et al. [The maximum principles for fractional Laplacian equations and their applications, Commun. Contemp. Math. 19(6) (2017) 1750018].
Disputing Dijkstra, and birthdays in base 2
Authors: Guzdial Mark , Adams Joel C. 
Published: February 2021

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Mark Guzdial takes issue with Dijkstra's metaphors, while Joel C. Adams considers how birthdays might differ if based on binary numbers.
Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1
Authors: Calvo Jennifer A. , Fritchman Briana , Hernandez Desiree , Persky Nicole S. , Johannessen Cory M. , Piccioni Federica , Kelch Brian A. , Cantor Sharon B. 
Published: February 2021

Abstract

FANCJ (BRIP1/BACH1) is a hereditary breast and ovarian cancer (HBOC) gene encoding a DNA helicase. Similar to HBOC genes, BRCA1 and BRCA2, FANCJ is critical for processing DNA inter-strand crosslinks (ICL) induced by chemotherapeutics, such as cisplatin. Consequently, cells deficient in FANCJ or its catalytic activity are sensitive to ICL-inducing agents. Unfortunately, the majority of FANCJ clinical mutations remain uncharacterized, limiting therapeutic opportunities to effectively use cisplatin to treat tumors with mutated FANCJ. Here, we sought to perform a comprehensive screen to identify FANCJ loss-of-function (LOF) mutations. We developed a FANCJ lentivirus mutation library representing approximately 450 patient–derived FANCJ nonsense and missense mutations to introduce FANCJ mutants into FANCJ knockout (K/O) HeLa cells. We performed a high-throughput screen to identify FANCJ LOF mutants that, as compared with wild-type FANCJ, fail to robustly restore resistance to ICL-inducing agents, cisplatin or mitomycin C (MMC). On the basis of the failure to confer resistance to either cisplatin or MMC, we identified 26 missense and 25 nonsense LOF mutations. Nonsense mutations elucidated a relationship between location of truncation and ICL sensitivity, as the majority of nonsense mutations before amino acid 860 confer ICL sensitivity. Further validation of a subset of LOF mutations confirmed the ability of the screen to identify FANCJ mutations unable to confer ICL resistance. Finally, mapping the location of LOF mutations to a new homology model provides additional functional information.

Implications:
We identify 51 FANCJ LOF mutations, providing important classification of FANCJ mutations that will afford additional therapeutic strategies for affected patients.
Clinical Course Long After Atrial Switch: A Novel Risk Score for Major Clinical Events
Authors: Woudstra Odilia I. , Zandstra Tjitske E. , Vogel Rosanne F. , van Dijk Arie P. J. , Vliegen Hubert W. , Kiès Philippine , Jongbloed Monique R. M. , Egorova Anastasia D. , Doevendans Pieter A. F. M. , Konings Thelma C. , Mulder Barbara J. M. , Tanck Michael W. T. , Meijboom Folkert J. , Bouma Berto J. 
Published: February 2021

Background
Patients with transposition of the great arteries corrected by an atrial switch operation experience major clinical events during adulthood, mainly heart failure (HF) and arrhythmias, but data on the emerging risks remain scarce. We assessed the risk for events during the clinical course in adulthood, and provided a novel risk score for event‐free survival.

Methods and Results
This multicenter study observed 167 patients with transposition of the great arteries corrected by an atrial switch operation (61% Mustard procedure; age, 28 [interquartile range, 24–36] years) for 13 (interquartile range, 9–16) years, during which 16 (10%) patients died, 33 (20%) had HF events, defined as HF hospitalizations, heart transplantation, ventricular assist device implantation, or HF‐related death, and 15 (9%) had symptomatic ventricular arrhythmias. Five‐year risk of mortality, first HF event, and first ventricular arrhythmia increased from 1% each at age 25 years, to 6% (95% CI, 4%–9%), 23% (95% CI, 17%–28%), and 5% (95% CI, 2%–8%), respectively, at age 50 years. Predictors for event‐free survival were examined to construct a prediction model using bootstrapping techniques. A prediction model combining age >30 years, prior ventricular arrhythmia, age >1 year at repair, moderate or greater right ventricular dysfunction, severe tricuspid regurgitation, and mild or greater left ventricular dysfunction discriminated well between patients at low (<5%), intermediate (5%–20%), and high (>20%) 5‐year risk (optimism‐corrected C‐statistic, 0.86 [95% CI, 0.82–0.90]). Observed 5‐ and 10‐year event‐free survival rates in low‐risk patients were 100% and 97%, respectively, compared with only 31% and 8%, respectively, in high‐risk patients.

Conclusions
The clinical course of patients undergoing atrial switch increasingly consists of major clinical events, especially HF. A novel risk score stratifying patients as low, intermediate, and high risk for event‐free survival provides information on absolute individual risks, which may support decisions for pharmacological and interventional management.
Insights From the Virtual Team Science: Rapid Deployment During COVID-19
Authors: Kilcullen Molly , Feitosa Jennifer , Salas Eduardo 
Published: February 2021

Objective To provide insights for organizations that must rapidly deploy teams to remote work. Background Modern situations, such as the COVID-19 pandemic, are rapidly accelerating the need for organizations to move employee teams to virtual environments, sometimes with little to no opportunities to prepare for the transition. It is likely that organizations will continually have to adapt to evolving conditions in the future. Method This review synthesizes the literature from several sources on best practices, lessons learned, and strategies for virtual teams. Information from each article deemed relevant was then extracted and de-identified. Over 64 best practices were independently and blindly coded for relevancy for the swift deployment of virtual teams. Results As a result of this review, tips for virtual teams undergoing rapid transition to remote work were developed. These tips are organized at the organization, team, and individual levels. They are further categorized under six overarching themes: norm setting, performance monitoring, leadership, supportive mechanisms, communication, and flexibility. Conclusion There is a significant deficit in the literature for best practices for virtual teams for the purposes of rapid deployment, leaving it to organizations to subjectively determine what advice to adhere to. This manuscript synthesizes relevant practices and provides insights into effective virtual team rapid deployment.
Characterizing the Effects of Explosive Ordnance Disposal Operations on the Human Body While Wearing Heavy Personal Protective Equipment
Authors: Wu Yi-Ning , Norton Adam , Zielinski Michael R. , Kao Pei-Chun , Stanwicks Andrew , Pang Patrick , Cring Charles H. , Flynn Brian , Yanco Holly A. 
Published: February 2021

Objective To provide a comprehensive characterization of explosive ordnance disposal (EOD) personal protective equipment (PPE) by evaluating its effects on the human body, specifically the poses, tasks, and conditions under which EOD operations are performed. Background EOD PPE is designed to protect technicians from a blast. The required features of protection make EOD PPE heavy, bulky, poorly ventilated, and difficult to maneuver in. It is not clear how the EOD PPE wearer physiologically adapts to maintain physical and cognitive performance during EOD operations. Method Fourteen participants performed EOD operations including mobility and inspection tasks with and without EOD PPE. Physiological measurement and kinematic data recording were used to record human physiological responses and performance. Results All physiological measures were significantly higher during the mobility and the inspection tasks when EOD PPE was worn. Participants spent significantly more time to complete the mobility tasks, whereas mixed results were found in the inspection tasks. Higher back muscle activations were seen in participants who performed object manipulation while wearing EOD PPE. Conclusion EOD operations while wearing EOD PPE pose significant physical stress on the human body. The wearer’s mobility is impacted by EOD PPE, resulting in decreased speed and higher muscle activations. Application The testing and evaluation methodology in this study can be used to benchmark future EOD PPE designs. Identifying hazards posed by EOD PPE lays the groundwork for developing mitigation plans, such as exoskeletons, to reduce physical and cognitive stress caused by EOD PPE on the wearers without compromising their operational performance.
Survival benefit from a second arterial conduit to the circumflex circulation persists in elderly after coronary artery bypass surgery
Authors: Luthra Suvitesh , Leiva-Juárez Miguel M , Malvindi Pietro G , Billing John S , Ohri Sunil K 
Published: February 2021

Background This retrospective propensity matched study investigated the impact of age on the survival benefit from a second arterial conduit to the left-sided circulation. Methods Data for isolated coronary artery bypass surgery were collected from October 2004 to March 2014. All patients with an internal mammary artery graft to left anterior descending artery and additional arterial or venous graft to the circumflex circulation were included. Propensity matching was used to balance co-variates and generate odds of death for each observation. Odds ratios (venous vs. arterial) were charted against age. Results The in-hospital mortality rate was 1.12% (arterial) vs. 1.24% (venous) (p = 0.77). The overall 10-year survival was 74.6% (venous) vs. 82.6% (arterial) (p = 0.001). A total of 1226 patients were successfully matched to the venous or arterial (second conduit to circumflex territory after left internal mammary artery to left anterior descending artery) cohorts. Odds ratio for death (venous to arterial) showed a linear decremental overall survival benefit for the second arterial graft to circumflex circulation with increasing age. Conclusions The survival benefit of a second arterial graft persists through all age groups with a gradual decline with increasing age over the decades. Elderly patients should not be denied a second arterial graft to the circumflex circulation based on age criterion alone.
Flow-through arterialized venous free thenar flaps for palmar soft tissue defects in fingers
Authors: Gu Song , Fu Huichao , Huang Yinjun , Xie Renguo 
Published: February 2021

Objective To evaluate the efficacy of venous free thenar flaps for reconstructing palmar soft tissue defects in fingers. Methods From December 2018 to October 2019, 11 patients with palmar soft tissue defects in fingers were treated using venous free thenar flaps. At the final follow-up, the range of thumb radial and palmar abduction on the injured side and opposite side was calculated. The total active movement (TAM) of the injured and opposite fingers and flap sensibility recovery were also recorded. Results The mean follow-up time was 13.4 months, all flaps survived, and all wounds at the donor sites healed with no skin necrosis. At the last follow-up, the average range of thumb radial abduction and thumb palmar abduction on the injured side was 96.6% and 95.9% of the value on the opposite side, respectively. The average TAM of the injured fingers was 98.2% of the value of the opposite fingers. Sensation in the flaps was restored to grade S2 to S3. Conclusion Venous free thenar flaps can be alternatives for reconstructing palmar soft tissue defects in fingers.
Message framing effects on food consumption: A social marketing perspective
Authors: Garg Nitika , Govind Rahul , Nagpal Anish 
Published: February 2021

Across two studies, this research examines the effects of positive versus negative framing of health messages on food consumption, in the relatively short and long run. Specifically, it studies the effects of multiple exposures to health messages over time (Study 1), using daily food consumption diary data. It replicates and extends those findings in a cross-sectional, single exposure setting to tease out the individual effects of positive and negative framing with consumption intentions as the dependent variable (Study 2). With this combination of an externally and internally valid setup, our research provides robust evidence of the associations of message effectiveness and behavioral outcomes. Our findings suggest that negative messages are more effective than positive messages in the short term but importantly, in the long term as well, suggesting that transforming consumption in the long term can be a viable social marketing objective with the appropriate message tactics. JEL Classification: M31, M37
Biomechanical but Not Strength or Performance Measures Differentiate Male Athletes Who Experience ACL Reinjury on Return to Level 1 Sports
Authors: King Enda , Richter Chris , Daniels Katherine A.J. , Franklyn-Miller Andy , Falvey Eanna , Myer Gregory D. , Jackson Mark , Moran Ray , Strike Siobhan 
Published: February 2021

Background: Performance measures such as strength, jump height/length, and change of direction (CoD) time during anterior cruciate ligament (ACL) rehabilitation have been used to determine readiness to return to play and identify those who may be at risk of rerupture. However, athletes may reach these criteria despite ongoing biomechanical deficits when performing these tests. Combining return-to-play criteria with an assessment of movement through 3-dimensional (3D) biomechanics in male field sports athletes to identify risk factors for ACL rerupture has not been explored previously. Purpose: To prospectively examine differences in strength, jump, and CoD performance and movement using 3D biomechanics in a cohort of male athletes playing level 1 sports (ie, multidirectional field sports that involve landing, pivoting, or CoD) between those who reinjured the reconstructed ACL (RI group) and those with no reinjury (NRI group) after 2 years of follow-up and to examine the ability of these differences to predict reinjury. Study Design: Cohort study; Level of evidence, 2. Methods: After primary ACL reconstruction (ACLR), 1045 male athletes were recruited and underwent testing 9 months after surgery including isokinetic strength, jump, and CoD performance measures as well as patient-reported outcomes and 3D biomechanical analyses. Participants were followed up after 2 years regarding ACL reinjury status. Differences were determined between the RI and NRI groups in patient-reported outcomes, performance measures, and 3D biomechanics on the ACLR side and symmetry between limbs. The ability of these measures to predict ACL reinjury was determined through logistic regression. Results: No differences were identified in strength and performance measures on the ACLR side or in symmetry. Biomechanical analysis indicated differences on the ACLR side primarily in the sagittal plane for the double-leg drop jump (effect size, 0.59-0.64) and greater asymmetry primarily in the frontal plane during unplanned CoD (effect size, 0.61-0.69) in the RI group. While these biomechanical test results were different between groups, multivariate regression modeling demonstrated limited ability (area under the curve, 0.67 and 0.75, respectively) to prospectively predict ACL reinjury. Conclusion: Commonly reported return-to-play strength, jump, and timed CoD performance measures did not differ between the RI and NRI groups. Differences in movement based on biomechanical measures during double-leg drop jump and unplanned CoD were identified, although they had limited ability to predict reinjury. Targeting these variables during rehabilitation may reduce reinjury risk in male athletes returning to level 1 sports after ACLR. Registration: NCT02771548 (ClinicalTrials.gov identifier).
Evaluating the Impact of a Critical Time Intervention Adaptation on Health Care Utilization among Homeless Adults with Mental Health Needs in a Large Urban Center
Authors: Reid Nadine , Mason Joyce , Kurdyak Paul , Nisenbaum Rosane , de Oliveira Claire , Hwang Stephen , Stergiopoulos Vicky 
Published: February 2021

Objective: This study evaluated the impact of a critical time intervention (CTI) adaptation on health care utilization outcomes among adults experiencing homelessness and mental health needs in a large urban center. Methods: Provincial population-based administrative data from Ontario, Canada, were used in a pre–post design for a cohort of 197 individuals who received the intervention between January 2013 and May 2014 and were matched to a cohort of adults experiencing homelessness who did not receive the intervention over the same time period. Changes in health care utilization outcomes in the year pre- and postintervention were evaluated using generalized estimating equations, and post hoc analyses evaluated differences between groups. Results: Pre–post analyses revealed statistically significant changes in health care utilization patterns among intervention recipients, including reduced inpatient service use and increased outpatient service use in the year following the intervention compared to the year prior. However, the matched cohort analysis found nonsignificant differences in health service use changes between a subgroup of intervention recipients and their matched counterparts. Conclusions: An adapted CTI model was associated with changes in health care utilization among people experiencing homelessness and mental health needs. However, changes were not different from those observed in a matched cohort. Rigorous study designs with adequate samples are needed to examine the effectiveness of CTI and local adaptations in diverse health care contexts.
Redefining Basic Needs for Higher Education: It’s More Than Minimal Food and Housing According to California University Students
Authors: Martinez Suzanna M. , Esaryk Erin E. , Moffat Laurel , Ritchie Lorrene 
Published: February 2021

Purpose: A student-specific definition of basic needs for higher education is warranted to inform programs and policies for underserved students. The purpose of this study was to: 1) explore how students define basic needs, 2) understand experiences of housing insecurity, and 3) understand experiences of food insecurity within the context of housing insecurity. Design: Qualitative research elicited student perceptions of basic needs and experiences of housing and food insecurity. Setting: Focus group discussions were conducted at 5 University of California campuses between February and March 2019. Participants: Undergraduate (n = 37) and graduate (n = 21) students were recruited from campus basic needs centers. Methods: Each student completed a brief survey. Researchers conducted 11 focus groups using a semi-structured interview guide. Transcripts were coded to identify themes. Results: Students were female (76%), age 23.6 (SD = 5.8) years; 46% were Pell grant recipients; and 52% were first-generation college students. Most had experienced food insecurity (98%) and 26% had experienced homelessness. Eight themes were identified: 1) students define basic needs as more than minimal food and shelter and as the responsibility of students and the university, 2) students encounter multifaceted housing insecurity issues, 3) affording rent is a priority that most often leads to experiencing food insecurity, 4) transportation barriers interfere with meeting students’ basic needs to succeed as students, 5) students with nontraditional characteristics, graduate students, and out-of-state students face unique challenges in meeting basic needs, 6) limited financial aid and lack of financial aid guidance are barriers to meeting basic needs, 7) fees contribute additional challenges to students meeting basic needs, and 8) additional university basic needs services are essential. Conclusion: A student-informed definition of basic needs included food, housing, mental health, sleep, hygiene, and transportation. This understanding of basic needs can inform future research, programs, and policy to address housing insecurity in higher education.
The Magnitude and Determinants of Partial Redemptions of Food Benefits in the Special Supplemental Nutrition Program for Women, Infants and Children (WIC)
Authors: Li Xuemei , McLaughlin Patrick W. , Saitone Tina L. , Sexton Richard J. 
Published: February 2021

Purpose: WIC provides food assistance to low-income pregnant and postpartum women, infants, and children ages 1- 4. A partial redemption (PR) occurs when a participant redeems only a portion of the prescribed benefit, thereby not obtaining the full nutritional benefit. We study the magnitude and determinants of PRs using electronic benefit transfer data. Design/Setting: Statistical analysis of all WIC transactions from Feb 2016 to Nov 2018. Subjects: Oklahoma WIC participants. Measures: The probability of a WIC household fully redeeming a food category. A random effects probit model is used to study determinants of PRs. Analysis: Estimate the marginal effects of key variables on households’ likelihood of full redemption: location—urban/rural, number of members in WIC, duration in the program, number of shopping trips, shopping venue, and prescribed foods. Results: Overall 18.5% of $ value of benefits are unredeemed, 29.3% excluding formula. Some foods have PRs > 40%. Only 17.3% of households fully redeem benefits in a given month. PRs increase with number of household members in WIC and duration of participation. PRs are lower for participants in rural locations, who shop more frequently, and who shop at WIC-specialized stores. Conclusions: Food packages with high PRs fail to impart prescribed benefits. Results pinpoint products and household characteristics associated with PRs, enabling targeted nutritional counseling and suggest food package choices need to be made with participant acceptance in mind.