bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fostering learning capacities for meaningful, healthy and efficient studying in undergraduate medical education: evaluation of a longitudinal learning workshop
Authors: Thye Miriam , Tauschel Diethard 
Published: September 2021

AbstractBackgroundAcademic studies place high demands on the development of learning capacities. Beyond learning techniques, knowledge about the effect of the learning environment, as well as the ability for self-regulation, self-determination and self-care play a major role in the development of learning skills. A longitudinal learning workshop was developed aiming to support academic learning life. The study at hand describes and evaluates this intervention.MethodsStudents participated in a seven-week program fostering reflection and training on physical, physiological, psychological and mental dimensions of learning. Fifty evaluations of medical students reflecting the workshop underwent qualitative analysis of open-ended questions concerning changes students experienced in their learning life. In addition, general satisfaction was measured quantitatively.ResultsQualitative results revealed an impact on five core dimensions of students´ learning life: knowledge gained about the process of learning, enhanced awareness of intrapersonal learning processes, getting easier into action, experience of change and raised skills of regulating one´s learning behavior. Students evaluate the workshop as helpful, supportive and as a source of guidance. Quantitative results demonstrated good overall satisfaction with the intervention.ConclusionsEducating knowledge about learning how to learn and providing skill training of how to regulate physiology, psychology and mentality should be taken into account in order to support the multidimensional learning life of students. Using a holistic, anthropologically grounded approach could be considered to enhance healthy, meaningful and efficient ways of learning. This learning workshop seems to be a useful and transferable tool to support students’ development of learning capacities.
The influence of semantic relevance on the discernment of product appearance and function
Authors: Wang Ching-Yi , Lin Yu-Er 
Published: September 2021

AbstractBackgroundThis study investigated the impact of semantic relevance on the ability to comprehend the appearance and function of a product, as presented in images.MethodsThe images used the constructs of Simile, Metaphor and Analogy to correspond to congruent, related and incongruent semantic structures, and measured the amplitude of Event-Related Potentials (ERPs) to compare these images with Landscape images. Sixteen participants with design-related educational backgrounds were invited to join in the ERP experiment.ResultsThe results found that the image depicting the Metaphor showed a stronger N600 amplitude in the right anterior region of the brain than the Landscape image and the Analogy image induced a stronger N600 effect in the left anterior and right anterior part of the brain than the Landscape image. However, the Simile image did not trigger the N600. The N600 was triggered when the meaning of the Metaphor and Analogy being presented could not be understood. This indicates that a greater processing effort to comprehend them than was required for Simile. Analogy has a wider N600 distribution than Metaphor in the anterior area, suggesting that Analogy would require higher-level thinking processes and more complex semantic processing mechanisms than Metaphor.ConclusionsThe N600 implicated that an assessment method to detect the semantic relationship between appearance and function of a product would assist in determining whether a symbol was suitable to be associated with a product.
The correlation between posterior tibial slope and dynamic anterior tibial translation and dynamic range of tibial rotation
Authors: Zee M.J.M , Keizer M.N.J , Dijkerman L , van Raaij J.J.A.M , Hijmans J.M. , Diercks R.L. 
Published: September 2021

Abstract
Purpose
The amount of passive anterior tibial translation (ATT) is known to be correlated to the amount of posterior tibial slope (PTS) in both anterior cruciate ligament-deficient and reconstructed knees. Slope-altering osteotomies are advised when graft failure after anterior cruciate ligament (ACL) reconstruction occurs in the presence of high PTS. This recommendation is based on studies neglecting the influence of muscle activation. On the other hand, if dynamic range of tibial rotation (rTR) is related to the amount of PTS, a “simple” anterior closing-wedge osteotomy might not be sufficient to control for tibial rotation. The purpose of this study was to evaluate the correlation between the amount of PTS and dynamic ATT and tibial rotation during high demanding activities, both before and after ACL reconstruction. We hypothesized that both ATT and rTR are strongly correlated to the amount of PTS.

Methods
Ten subjects were studied both within three months after ACL injury and one year after ACL reconstruction. Dynamic ATT and dynamic rTR were measured using a motion-capture system during level walking, during a single-leg hop for distance and during a side jump. Both medial and lateral PTS were measured on MRI. A difference between medial and lateral PTS was calculated and referred to as Δ PTS. Spearman’s correlation coefficients were calculated for the correlation between medial PTS, lateral PTS and Δ PTS and ATT and between medial PTS, lateral PTS and Δ PTS and rTR.

Results
Little (if any) to weak correlations were found between medial, lateral and Δ PTS and dynamic ATT both before and after ACL reconstruction. On the other hand, a moderate-to-strong correlation was found between medial PTS, lateral PTS and Δ PTS and dynamic rTR one year after ACL reconstruction.

Conclusion
During high-demand tasks, dynamic ATT is not correlated to PTS. A compensation mechanism may be responsible for the difference between passive and dynamic ATT in terms of the correlation to PTS. A moderate-to-strong correlation between amount of PTS and rTR indicates that such a compensation mechanism may fall short in correcting for rTR. These findings warrant prudence in the use of a pure anterior closing wedge osteotomy in ACL reconstruction.

Trial registration
Netherlands Trial Register, Trial 7686. Registered 16 April 2016—Retrospectively registered.

Level of evidence
Level 2, prospective cohort study
Experimental validation of a new technique for the assessment of posterior tibial translation (ABC angle) after posterior cruciate ligament rupture
Authors: Severyns M. , Rollet M.-E. , Vendeuvre T. , Pesenti S. , Benzakour A. , Rouvillain J.-L. 
Published: September 2021

Abstract
Background
The aim of this cadaver study was to evaluate an original technique for measuring posterior tibial translation based on an angle value instead of a distance value, with and without posterior stress application. It was hypothesized that an angle measurement of the posterior tibial translation would confirm the presence of a PCL tear with the knee flexed and completely extended.

Method
Using fresh cadavers, a set of strict lateral views were taken by fluoroscopy with the knee at 0°, 45° and 90° flexion on the intact knee and after transecting the PCL. The primary endpoint was the change in the posterior translation measured using a new technique, the ABC angle. This measurement was compared to the conventional posterior translation distance measurement with and without a posterior stress placed on the knee.

Results
Application of a posterior stress revealed clear changes in posterior translation after PCL transection with the knee at 0° for the angle technique and at 45° and 90° for the two techniques (p < 0.05). Contrary to the reference method, the ABC angle method found a statistically significant difference in posterior translation with the knee in extension.

Conclusion
Our technique provides a reliable radiographic measurement of posterior translation with the knee in extension, which should make it easier to acquire radiographs in patients who have pain with knee flexion. This angular measurement also has the advantage of not needing length calibration contrary to the reference technique.

Level of evidence
IV
Killer immunoglobulin-like receptor 2DS5 is associated with recovery from coronavirus disease 2019
Authors: Lesan Vadim , Bewarder Moritz , Metz Carlos , Becker André , Mang Sebastian , Regitz Evi , Thurner Lorenz , Neumann Frank , Kos Igor , Christofyllakis Konstantinos , Danziger Guy , Stilgenbauer Stephan , Bals Robert , Lepper Philipp M. , Kaddu-Mulindwa Dominic , Rixecker Torben 
Published: September 2021

AbstractBackgroundDespite numerous advances in the identification of risk factors for the development of severe coronavirus disease 2019 (COVID-19), factors that promote recovery from COVID-19 remain unknown. Natural killer (NK) cells provide innate immune defense against viral infections and are known to be activated during moderate and severe COVID-19. Killer immunoglobulin-like receptors (KIR) mediate NK cell cytotoxicity through recognition of an altered MHC-I expression on infected target cells. However, the influence of KIR genotype on outcome of patients with COVID-19 has not been investigated so far. We retrospectively analyzed the outcome associations of NK cell count and KIR genotype of patients with COVID-19 related severe ARDS treated on our tertiary intensive care unit (ICU) between February and June 2020 and validated our findings in an independent validation cohort of patients with moderate COVID-19 admitted to our tertiary medical center.ResultsMedian age of all patients in the discovery cohort (n = 16) was 61 years (range 50–71 years). All patients received invasive mechanical ventilation; 11 patients (68%) required extracorporeal membrane oxygenation (ECMO). Patients who recovered from COVID-19 had significantly higher median NK cell counts during the whole observational period compared to patients who died (121 cells/µL, range 16–602 cells/µL vs 81 cells/µL, range 6–227 cells/µL,p-value = 0.01). KIR2DS5 positivity was significantly associated with shorter time to recovery (21.6 ± 2.8 days vs. 44.6 ± 2.2 days,p-value = 0.01). KIR2DS5 positivity was significantly associated with freedom from transfer to ICU (0% vs 9%,p-value = 0.04) in the validation cohort which consisted of 65 patients with moderate COVID-19.ConclusionNK cells and KIR genotype might have an impact on recovery from COVID-19.
Transformation of sugarcane molasses into fructooligosaccharides with enhanced prebiotic activity using whole-cell biocatalysts from Aureobasidium pullulans FRR 5284 and an invertase-deficient Saccharomyces cerevisiae 1403-7A
Authors: Khatun Most Sheauly , Hassanpour Morteza , Mussatto Solange I. , Harrison Mark D. , Speight Robert E. , O’Hara Ian M. , Zhang Zhanying 
Published: September 2021

AbstractFructooligosaccharides (FOS) can be used as feed prebiotics, but are limited by high production costs. In this study, low-cost sugarcane molasses was used to produce whole-cell biocatalysts containing transfructosylating enzymes by Aureobasidium pullulans FRR 5284, followed by FOS production from molasses using the whole-cells of A. pullulans. A. pullulans in molasses-based medium produced cells and broth with a total transfructosylating activity of 123.6 U/mL compared to 61.0 and 85.8 U/mL in synthetic molasses-based and sucrose-based media, respectively. It was found that inclusion of glucose in sucrose medium reduced both transfructosylating and hydrolytic activities of the produced cells and broth. With the use of pure glucose medium, cells and broth had very low levels of transfructosylating activities and hydrolytic activities were not detected. These results indicated that A. pullulans FRR 5284 produced both constitutive and inducible enzymes in sucrose-rich media, such as molasses while it only produced constitutive enzymes in the glucose media. Furthermore, treatment of FOS solutions generated from sucrose-rich solutions using an invertase-deficient Saccharomyces yeast converted glucose to ethanol and acetic acid and improved FOS content in total sugars by 20–30%. Treated FOS derived from molasses improved the in vitro growth of nine probiotic strains by 9–63% compared to a commercial FOS in 12 h incubation. This study demonstrated the potential of using molasses to produce FOS for feed application.
Pulsating hemorrhagic varicose veins caused by tricuspid valve regurgitation: report of a case treated by laser ablation and foam sclerotherapy
Authors: Guntani Atsushi , Yamashita Sho , Mii Shinsuke 
Published: September 2021

Abstract
Background
Varicose veins are one of the most common disease; however, secondary varicose veins caused by tricuspid valve regurgitation (TVR) are rare.

Case presentation
A patient who developed pulsating bleeding from superficial varicose veins due to TVR was successfully treated by endovenous laser ablation (EVLA) of the great saphenous vein (GSV) and repeated foam sclerotherapy of varicose veins. There were no complications, such as rebleeding or recanalization of the GSV during the 1-year follow-up period.

Conclusions
We herein report a rare case of pulsatile hemorrhagic varicose veins caused by TVR that was successfully managed by combined treatment of EVLA and foam sclerotherapy. When pulsatile varicose veins are found, the presence of TVR should be suspected.
The SOFIA pilot trial: a cluster-randomized trial of coordinated, co-produced care to reduce mortality and improve quality of life in people with severe mental illness in the general practice setting
Authors: Rozing M. P. , Jønsson A. , Køster-Rasmussen R. , Due T. D. , Brodersen J. , Bissenbakker K. H. , Siersma V. , Mercer S. W. , Guassora A. D. , Kjellberg J. , Kjellberg P. K. , Nielsen M. H. , Christensen I. , Bardram J. E. , Martiny F. , Møller A. , Reventlow S. ,   on behalf of the SOFIA Study Group
Published: September 2021

Abstract
Background
People with severe mental illness (SMI) have an increased risk of premature mortality, predominantly due to somatic health conditions. Evidence indicates that primary and tertiary prevention and improved treatment of somatic conditions in patients with SMI could reduce this excess mortality. This paper reports a protocol designed to evaluate the feasibility of a coordinated co-produced care program (SOFIA model, a Danish acronym for Severe Mental Illness and Physical Health in General Practice) in the general practice setting to reduce mortality and improve quality of life in patients with severe mental illness.

Methods
The SOFIA pilot trial is designed as a cluster randomized controlled trial targeting general practices in two regions in Denmark. We aim to include 12 practices, each of which is instructed to recruit up to 15 community-dwelling patients aged 18 and older with SMI. Practices will be randomized by a computer in a ratio of 2:1 to deliver a coordinated care program or usual care during a 6-month study period. A randomized algorithm is used to perform randomization. The coordinated care program includes educational training of general practitioners and their clinical staff educational training of general practitioners and their clinical staff, which covers clinical and diagnostic management and focus on patient-centered care of this patient group, after which general practitioners will provide a prolonged consultation focusing on individual needs and preferences of the patient with SMI and a follow-up plan if indicated. The outcomes will be parameters of the feasibility of the intervention and trial methods and will be assessed quantitatively and qualitatively. Assessments of the outcome parameters will be administered at baseline, throughout, and at end of the study period.

Discussion
If necessary the intervention will be revised based on results from this study. If delivery of the intervention, either in its current form or after revision, is considered feasible, a future, definitive trial to determine the effectiveness of the intervention in reducing mortality and improving quality of life in patients with SMI can take place. Successful implementation of the intervention would imply preliminary promise for addressing health inequities in patients with SMI.

Trial registration
The trial was registered in Clinical Trials as of November 5, 2020, with registration number NCT04618250.
Protocol version: January 22, 2021; original version
The case for increased centralization in integration governance: the neglected perspective
Authors: Hernes Vilde 
Published: September 2021

AbstractLocal autonomy is a highly promoted feature in European governance, and the integration field is no exception. In the integration literature, values and considerations favoring local autonomy are often emphasized, while values and considerations underpinning central steering has received less analytical attention, thus a more nuanced perspective in studies of central–local governance relations is warranted. This commentary identifies general dilemmas in central–local governance which expose clear justifications for both local autonomy and central steering. Furthermore, it presents empirical examples of policy changes regulating central–local governance in the Scandinavian countries where increased centralization has been introduced with reference to promoting values and considerations favoring central steering, such as a fairer distribution of responsibilities between local authorities, legal safeguards for individuals, and equal service provision across the country. Lastly, it suggests how future studies of central–local governance could benefit from of taking a more nuanced perspective.
Retinoblastoma and mosaic 13q deletion: a case report
Authors: Gargallo Pablo , Oltra Silvestre , Balaguer Julia , Barranco Honorio , Yáñez Yania , Segura Vanessa , Juan-Ribelles Antonio , Calabria Inés , Llavador Margarita , Castel Victoria , Cañete Adela 
Published: September 2021

Abstract
Background
Patients with 13q-syndrome are at risk of retinoblastoma when the RB1 gene, located in the chromosomal band 13q14.2, is deleted. This syndrome is frequently associated with congenital malformations and developmental delay, although these signs could be mild. Mosaic 13q-deletion patients have been previously reported in the literature; their phenotype is variable, and they may not be recognized.

Case presentation
Retinoblastoma diagnosed in a child with 13q-mosaicism confirmed in blood, oral mucosa, healthy retina and retinoblastoma. A second RB1 hit is present exclusively in the retinoblastoma sample (RB1 c.958C>T p.Arg320Ter). Other detected molecular events in retinoblastoma are 6p12.3pter gain and 6q25.3qter loss. Clinical examination is unremarkable except for clinodactyly of the right fifth finger.

Discussion and conclusions
We describe a case of mosaic 13q deletion syndrome affected by retinoblastoma. Molecular data obtained from the tumor analysis are similar to previous data available about this malignancy. High clinical suspicion is essential for an adequate diagnosis of mosaic cases.
Too precarious to walk: an integrated “three delays” framework for modeling barriers to maternal health care and birth registration among stateless persons and irregular migrants in Malaysia
Authors: Cheong Amanda R. , Baltazar Mary Anne K. 
Published: September 2021

AbstractThis study extends Thaddeus and Maine’s (1994) “three delays” framework to model the interrelated barriers to maternal health care and birth registration. We focus on stateless persons and irregular migrants, populations that are especially at risk of being “left behind” in United Nations member states’ efforts to “provide legal identity to all” as part of the 2030 Sustainable Development Agenda. Drawing on qualitative fieldwork conducted in Sabah, Malaysia, we model delays in accessing maternal health care and birth registration as an integrated, cyclical process. We identify the political and legal barriers that stateless or migrant families confront while deciding to make institutional contact (Phase I), identifying and reaching health or registering institutions (Phase II), and receiving adequate and appropriate treatment (Phase III). We find that exclusion from one system raises the risk of exclusion from the other, resulting in a range of negative consequences, including increased health risks, governments’ impaired ability to monitor population health, and the perpetuation of intergenerational cycles of legal exclusion.
Rapid mortality surveillance using a national population register to monitor excess deaths during SARS-CoV-2 pandemic in South Africa
Authors: Dorrington Rob E. , Moultrie Tom A. , Laubscher Ria , Groenewald Pam J. , Bradshaw Debbie 
Published: September 2021

AbstractThis paper describes how an up-to-date national population register recording deaths by age and sex, whether deaths were due to natural or unnatural causes, and the offices at which the deaths were recorded can be used to monitor excess death during the SARS-CoV-2 pandemic, both nationally, and sub-nationally, in a country with a vital registration system that is neither up to date nor complete. Apart from suggesting an approach for estimating completeness of reporting at a sub-national level, the application produces estimates of the number of deaths in excess of those expected in the absence of the SARS-CoV-2 epidemic that are highly correlated with the confirmed number of COVID-19 deaths over time, but at a level 2.5 to 3 times higher than the official numbers of COVID-19 deaths. Apportioning the observed excess deaths more precisely to COVID, COVID-related and collateral deaths, and non-COVID deaths averted by interventions with reduced mobility and gatherings, etc., requires access to real-time cause-of-death information. It is suggested that the transition from ICD-10 to ICD-11 should be used as an opportunity to change from a paper-based system to electronic capture of the medical cause-of-death information.
Virtual non-calcium dual-energy CT: clinical applications
Authors: D’Angelo Tommaso , Albrecht Moritz H. , Caudo Danilo , Mazziotti Silvio , Vogl Thomas J. , Wichmann Julian L. , Martin Simon , Yel Ibrahim , Ascenti Giorgio , Koch Vitali , Cicero Giuseppe , Blandino Alfredo , Booz Christian 
Published: September 2021

AbstractDual-energy CT (DECT) has emerged into clinical routine as an imaging technique with unique postprocessing utilities that improve the evaluation of different body areas. The virtual non-calcium (VNCa) reconstruction algorithm has shown beneficial effects on the depiction of bone marrow pathologies such as bone marrow edema. Its main advantage is the ability to substantially increase the image contrast of structures that are usually covered with calcium mineral, such as calcified vessels or bone marrow, and to depict a large number of traumatic, inflammatory, infiltrative, and degenerative disorders affecting either the spine or the appendicular skeleton. Therefore, VNCa imaging represents another step forward for DECT to image conditions and disorders that usually require the use of more expensive and time-consuming techniques such as magnetic resonance imaging, positron emission tomography/CT, or bone scintigraphy. The aim of this review article is to explain the technical background of VNCa imaging, showcase its applicability in the different body regions, and provide an updated outlook on the clinical impact of this technique, which goes beyond the sole improvement in image quality.