bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-cultural adaptation and validation of the Chinese version of the modified Fresno test for physical therapists
Authors: Chen Li-Yang , Lue Yi-Jing , Wu Po-Hsun , Kuo Yi-Liang 
Published: January 2025

Abstract
Background
The modified Fresno test was developed to assess knowledge and skills related to evidence-based practice among physical therapists and students, however no Chinese version is available. Therefore, the aim of this study was to cross-culturally adapt the English version of the modified Fresno test into Chinese and to evaluate its validity and reliability.

Methods
This was a cross-sectional validation study. During Phase 1 cross-cultural adaptation, forward translation, synthesis, back-translation, expert review, and prefinal test were carried out. Content validity was analyzed. During Phase 2 validation, two groups representing different levels of evidence-based practice competence completed the tests twice, two weeks apart. Known-group validity, internal consistency, and test-retest reliability were analyzed.

Results
Phase 1: According to the expert review, the Chinese version of the modified Fresno test demonstrated good content validity (item-level content validity index = 0.93 to 1.0; scale-level content validity index = 0.99). Phase 2: The expert group scored (115.3 ± 36.2) significantly higher than the novice group did (79.7 ± 25.8) for the entire test (p = 0.01), suggesting good known-group validity. However, the superior performance of the expert group over the novice group was not consistently found across all the questions on the test. In addition, the internal consistency was good (Cronbach’s α = 0.96) and the test-retest reliability (ICC2,1 = 0.89, 95% CI = 0.81 to 0.94) was good to excellent.

Conclusions
The Chinese version of the modified Fresno test is a valid and reliable tool for objectively assessing evidence-based practice knowledge and skills in Chinese-speaking physical therapists and students.
Specifically blocking αvβ8-mediated TGF-β signaling to reverse immunosuppression by modulating macrophage polarization
Authors: Guo Cuicui , Sun Hui , Du Yulei , Dai Xiaodong , Pang Yu , Han Zhen , Xiong Xinhui , Li Shaowei , Zhang Junhua , Zheng Qingbing , Gui Xun 
Published: January 2025

Abstract
Background
Targeting the TGF-β pathway in tumor therapy has proven challenging due to the highly context-dependent functions of TGF-β. Integrin αvβ8, a pivotal activator of TGF-β, has been implicated in TGF-β signaling within tumors, as demonstrated by the significant anti-tumor effects of anti-αvβ8 antibodies. Nevertheless, the expression profile of αvβ8 remains a subject of debate, and the precise mechanisms underlying the anti-tumor effects of anti-αvβ8 antibodies are not yet fully elucidated.

Methods
We utilized single-cell RNA sequencing to assess αvβ8 expression across various human tumors. An anti-αvβ8 antibody was developed and characterized for its binding and blocking properties in vitro. Cryo-EM single-particle analysis was employed to study the detailed interaction between αvβ8 and the antibody Fab fragment. The anti-tumor efficacy of the antibody was evaluated in syngeneic mouse models with varying levels of αvβ8 expression, both as a monotherapy and in combination with PD-1 antibodies. Human PBMCs were isolated to investigate αvβ8 expression in myeloid cells, and macrophages were exposed to the antibody to study its impact on macrophage polarization. Pharmacokinetic studies of the αvβ8 antibody were conducted in cynomolgus monkeys.

Results
Integrin αvβ8 is notably expressed in certain tumor types and tumor-infiltrating macrophages. The specific αvβ8 antibody 130H2 demonstrated high affinity, specificity, and blocking potency in vitro. Cryo-EM analysis further revealed that 130H2 interacts exclusively with the β8 subunit, without binding to the αv subunit. In vivo studies showed that this antibody significantly inhibited tumor growth and alleviated immunosuppression by promoting immune cell infiltration. Furthermore, combining the antibody with PD-1 inhibition produced a synergistic anti-tumor effect. In human PBMCs, monocytes exhibited high αvβ8 expression, and the antibody directly modulated macrophage polarization. Tumors with elevated αvβ8 expression were particularly responsive to 130H2 treatment. Additionally, favorable pharmacokinetic properties were observed in cynomolgus monkeys.

Conclusions
In summary, integrin αvβ8 is highly expressed in certain tumors and tumor-infiltrating macrophages. Targeting αvβ8 with a blocking antibody significantly inhibits tumor growth by modulating macrophage polarization and enhancing immune cell infiltration. Combining αvβ8 targeting with PD-1 treatment markedly increases the sensitivity of immune-excluded tumors. These results support further clinical evaluation of αvβ8 antibodies.

Graphical abstract
The effect of fintech M&As on short-term stock return in the context of macroeconomic environment
Authors: Ochirova Elena , Miriakov Mikhail 
Published: January 2025

AbstractMergers and acquisitions (M&A) with financial technology (fintech) companies can be an effective way for firms to obtain new technologies and capabilities. However, the market reaction to fintech M&A announcements has received limited attention in the empirical academic literature. This study assesses the impact of fintech M&As on stock returns and examines whether macroeconomic variables influence the abnormal return of fintech M&As. Using event study analysis, we found that fintech M&A announcements generate a significant positive short-term abnormal return. Furthermore, we demonstrated that macroeconomic parameters, including Gross domestic product (GDP) growth, inflation rate, the share of services in GDP, and aggregate export growth, positively affect abnormal returns. In contrast, private investment, consumer spending, and an economy’s size negatively influence fintech M&As’ abnormal returns.
Unlocking the diversification benefits of DeFi for ASEAN stock market portfolios: a quantile study
Authors: Ali Shoaib , Manel Youssef 
Published: January 2025

AbstractThis study examines the return connectedness between decentralized finance (DeFi)’s and the Association of Southeast Asian Nations (ASEAN) stock markets using the quantile vector autoregressive framework, which allows us to investigate the connectedness at conditional quantiles. Our sample includes four major DeFi’s and six ASEAN stock markets, spanning from March 2018 to December 2022. The static results indicate a moderate level of return transmission between the system at mean and median quantile. This propagation increases substantially under extreme market conditions, establishing an asymmetric transmission across quantiles. Despite being a relatively new asset class, DeFi dominates the equity market and acts as the primary shock transmitter to the system in most instances. The dynamic analysis reveals that total system connectedness fluctuates over time and quantiles. The total system connectedness peaked during the COVID-19 and the Russia–Ukraine conflict period, indicating the impact of global events on system transmission. The optimal weight and hedge ratio estimated using the DCC-GARCH model indicate that DeFi is beneficial for portfolio construction and risk management. The rising trend in dynamic optimal weight and hedge ratio during the COVID-19 pandemic demonstrates that investors should decrease their investments in DeFi and increase hedging costs. Therefore, portfolio managers and investors should readjust their portfolio allocation in a timely manner according to different market states to build additional effective hedging and diversification strategies to avoid large losses and to reduce portfolio risk exposure.
A novel recycling technology for chrome shavings: efficient separation of chromium and collagen fibers based on swelling inhibition in alkali-acid processing
Authors: Chen Honghong , Li Minghui , Chattha Sadaqat Ali , Zhang Xu , Peng Biyu , Zhang Chunxiao 
Published: January 2025

AbstractDechroming techniques with a low degree of collagen hydrolysis and a high degree of dechroming are more suitable for the resource utilization of chrome shavings. However, achieving efficient simultaneous separation of chromium and collagen fibers is challenging because swollen collagen fibers absorb a large amount of chromium-containing water and are prone to hydrolysis after dechroming. This study investigated the correlation between the swelling inhibition of collagen fibers and the extent of dechroming and optimized the process parameters. The results demonstrated that the incorporation of neutral salt significantly increased the rate of dechroming and reduced the degree of collagen hydrolysis. The optimized alkali-acid-washing process was as follows: soaking in a Na2SO4 solution (4%, w/w), dechroming with a NaOH solution at pH 13.5, rapidly adjusting the pH of reactants to 1.0 with an H2SO4 solution, pressure filtration, washing the filtered residue with 5% Na2SO4 solution (w/w) at pH 1.0, followed by pressure filtration. After two cycles of the alkali-acid-washing process, the filtered residue was washed with an oxalic acid-Na2SO4 solution (5%, w/w) and pressure-filtered again. The chromium content of recovered collagen was reduced to 34.0 mg/kg. The degree of collagen hydrolysis was confined to 9% with the fiber morphology completely retained. The wastewater chromium content was reduced to 0.4 mg/L after the simple precipitation, meeting the direct discharge requirement. The recycled chrome was utilized as chrome-tanning agent. These results suggested that the established method could be a promising resource reutilization route for the sustainable development of the leather industry.
Graphical abstract
Advances in the molecular mechanism of grapevine resistance to fungal diseases
Authors: Li Zhi , Wu Ronghui , Guo Fangying , Wang Yuejin , Nick Peter , Wang Xiping 
Published: January 2025

AbstractGrapevine is an important economic fruit tree worldwide, but grape production has been plagued by a vast number of fungal diseases, which affect tree vigor and the quality and yield of berries. To seek remedies for such issues, researchers have always been committed to conventional and biotechnological breeding. In recent years, increasing progress has been made in elucidating the molecular mechanisms of grape–pathogenic fungi interactions and resistance regulation. Here, we summarize the current knowledge on the molecular basis of grapevine resistance to fungal diseases, including fungal effector-mediated susceptibility and resistance, resistant regulatory networks in grapevine, innovative approaches of genetic transformation, and strategies to improve grape resistance. Understanding the molecular basis is important for exploring and accurately regulating grape resistance to fungal diseases.
Appetite-related Gut Hormone Responses to Feeding Across the Life Course
Authors: Holliday Adrian , Horner Katy , Johnson Kelsie O , Dagbasi Aygul , Crabtree Daniel R 
Published: January 2025

Abstract
Appetite-related hormones are secreted from the gut, signaling the presence of nutrients. Such signaling allows for cross-talk between the gut and the appetite-control regions of the brain, influencing appetite and food intake. As nutritional requirements change throughout the life course, it is perhaps unsurprising that appetite and eating behavior are not constant. Changes in appetite-related gut hormones may underpin these alterations in appetite and eating.
In this article, we review evidence of how the release of appetite-related gut hormones changes throughout the life course and how this impacts appetite and eating behaviour. We focus on hormones for which there is the strongest evidence of impact on appetite, food intake, and body weight: the anorexigenic glucagon like peptide-1, peptide tyrosine tyrosine, and cholecystokinin, and the orexigenic ghrelin. We consider hormone concentrations, particularly in response to feeding, from the very early days of life, through childhood and adolescence, where responses may reflect energy requirements to support growth and development. We discuss the period of adulthood and midlife, with a particular focus on sex differences and the effect of menstruation, pregnancy, and menopause, as well as the potential influence of appetite-related gut hormones on body composition and weight status. We then discuss recent advancements in our understanding of how unfavorable changes in appetite-related gut hormone responses to feeding in later life may contribute to undernutrition and a detrimental aging trajectory. Finally, we briefly highlight priorities for future research.
A comparative view of human and mouse telencephalon inhibitory neuron development
Authors: Chung Changuk , Girgiss Joseph , Gleeson Joseph G. 
Published: January 2025

ABSTRACT
Human GABAergic inhibitory neurons (INs) in the telencephalon play crucial roles in modulating neural circuits, generating cortical oscillations, and maintaining the balance between excitation and inhibition. The major IN subtypes are based on their gene expression profiles, morphological diversity and circuit-specific functions. Although previous foundational work has established that INs originate in the ganglionic eminence regions in mice, recent studies have questioned origins in humans and non-human primates. We review the origins of INs in mice and compare with recent findings from primary human prenatal brain tissue culture experiments and lineage analysis from somatic variants in neurotypical human cadavers and human brain organoids. Together, these studies suggest potential primate- or human-specific processes that may have been overlooked in mouse models and could have implications for brain disorders.
Μέτρηση της αυτοαποτελεσματικότητας των διευθυντών/ντριών στη συμπεριληπτική ηγεσία
Authors: Τσιολπίδου Ξανθούλα , Κουτούζης Εμμανουήλ 
Published: January 2025

Η Ηγεσία για τη Συμπερίληψη στα Σχολεία προτείνεται ως μία εναλλακτική προσέγγιση στην εκπαιδευτική ηγεσία που συνδυάζει μετασχηματιστικές, παιδαγωγικές και συνεργατικές πρακτικές και επιδιώκει τη δημιουργία σχολείων ικανών που θα παρέχουν υψηλής ποιότητας εκπαίδευση σε όλους αδιακρίτως τους μαθητές. Οι πεποιθήσεις αποτελεσματικότητας των Διευθυντών/ντριών να εφαρμόσουν πρακτικές συμπεριληπτικής ηγεσίας θα καθορίσει, σύμφωνα με την κοινωνιογνωστική θεωρία, τη στάση, την επιμονή και την προσήλωσή τους στον στόχο της Συμπερίληψης. Στο άρθρο που ακολουθεί παρουσιάζεται η διαδικασία για την ανάπτυξη ενός κατάλληλου ερευνητικού εργαλείου για τη μέτρηση των πεποιθήσεων αυτοαποτελεσματικότητας των Διευθυντών στην Ηγεσία για τη Συμπερίληψη στα Σχολεία. Ο σχεδιασμός, η κατασκευή και ο έλεγχός του πραγματοποιήθηκαν σύμφωνα με τη μεθοδολογία De Vellis. Δοκιμάστηκε σε 392 διευθυντές/ντριες σχολείων 22 διαφορετικών Διευθύνσεων της Πρωτοβάθμιας Εκπαίδευσης της χώρας. Οι αναλύσεις ανέδειξαν τρεις (3) παράγοντες, με συνολικά 20 δηλώσεις που ερμήνευαν ποσοστό 64,83% της συνολικής διακύμανσης. Ο συνολικός συντελεστής αξιοπιστίας Cronbach α προέκυψε υψηλός (=0,95) όπως και οι επιμέρους. Ο έλεγχος για τη συντρέχουσα εγκυρότητα έδειξε μέτρια θετική, στατιστικά σημαντική, συσχέτιση (r>0,5, p<0,001) της αντιληπτής Αυτοαποτελεσματικότητας στην Ηγεσία για τη Συμπερίληψη στα Σχολεία με τη Στάση των Διευθυντών/ντριών απέναντι στη Συμπερίληψη για όλους και την Επαγγελματική τους Δέσμευση). Περαιτέρω μελέτες μπορούν να επιβεβαιώσουν τη δομή και τη χρησιμότητά της.
Protection and Monitoring System for LPG Leaks and Fires in Arduino-Based Rooms
Authors: Triyatno Ivan , Yudhana Anton 
Published: January 2025

This research is a development of previous research in overcoming of LPG gas leaks that cause fires. The system is designed using the main sensor MQ-6 and DHT22 sensors which will detect the gas concentration and temperature in the room, the protection system is equipped with an exhaust as a room freshener and a buzzer as a direct warning alarm and a water pump to extinguish a fire. And all of data will be displayed on the application Blynk and will send a notification on email users by using a Wi-Fi network. This system has succeeded in detecting the concentration of LPG gas with a sensor detection distance of 1 cm to 7 cm getting an average time of 1.6 seconds and percentage of error comparison 2.52%. In normal temperature detection, the percentage error is 1.14% and normal humidity is 2.98%, As for detection of rising temperature by using of wax media, the percentage error is 1.84% and humidity 1.87%. From these tests and getting results with a small percentage value this system can already be used and runs as well.
Visual Studio Application for Generation Power System Reliability Calculations
Authors: Alfi Ikrima , Kusmayana Rifqi Fauzan 
Published: January 2025

Power system reliability is affected by the reliability of its sub-systems, including generator reliability. The reliability of a power plant can be seen, among others, based on the LOLE (Loss of Load Expectation) index. Processing and calculating data using excel or matlab will take a lot of time and effort. This is unfavorable for system evaluation which is a routine activity. The contribution of this research is to create an easy data processing method with a user-friendly display using Java programming-based Visual Studio. The research data uses generator operating data in 2018 and 2019 Hydroelectric Power Plant Ir. H. Djuanda. Calculations using visual studio have been validated with calculations using Excel. LOLE calculation results in 2018 was 0.17356748092842464 days/year and for 2019 it produced a LOLE of 0.006204969593183424 days/year. The results obtained did not exceed the PLN standard, namely 1 days/year, in other words, in 2018 and 2019 Hydroelectric Power Plant Ir. H. Djuanda has a good level of reliability.
Analysis of Lightning Strike Impulse Strategies in Electricity Distribution Channels Utilizing Mixed Lines
Authors: Burhan Muhammad Iswal , Sari Dessy Ana Laila 
Published: January 2025

To ensure the operational security of these systems and to give higher quality electricity to all users, it is important to assess the transient behavior of electric power transmission and distribution systems when they are challenged to varied forms like lightning discharges, which in this research is focused to determine the effect by utilizing the mixed line configuration on the impulse voltage of lightning strike on the 20 kV distribution line. This experiment was carried out using sources of data through channel documentation on Makassar City Polda Feeders with an airway length (SUTM) of 7.8 km and a cable channel length (SKTM) of 2 km obtained from PT. PLN (Persero) Makassar Branch and then input into the ATP-EMTP simulation process with either a simulation of 20 and 50 kA strikes at distances of 2.5, 4.5 and 6.5 km with lightning impulses of 1.2/50 and 8/20 µs. configuration of lines at the transition point and also the end of the cable channel depending on the magnitude of the lightning current, the location of the strike, and the lightning impulse. Lightning peak current is proportional to the voltage response at the transition point and the end of the cable, and the effect on lightning impulse peak voltage is generated at the transition point and the end of the cable. According to research results of initial research, the use of mixed channel lines can decrease the impulse voltage is 20 kV distribution lines.
QR code wristbands in palliative care: enhancing efficiency and outcomes
Authors: Harding Ellin , Sivell Stephanie , O'Brian Ed , Sheeran Liba , Pease Nikki 
Published: January 2025

Background: Poor, inaccurate and inconsistent patient information hinders ambulance clinicians' management of patients receiving palliative care, often leading to unnecessary hospital admissions. Digital records, such as the Electronic Palliative Care Coordination System (EPaCCS), offer solutions. Aims: This study explores ambulance clinicians' perceptions (including paramedics, emergency medical technicians (EMTs) and advanced paramedic practitioners (APPs)) of a QR code-based electronic palliative care system, focusing on the content and format of information and its utility in clinical decision-making. Methods: Two focus groups with Welsh Ambulance Service Trust ambulance clinicians discussed a QR code wristband system. Data were thematically analysed. Findings: Key themes included improved access to patient information, better decision-making, greater family involvement, format and usability, and concerns regarding data governance. Conclusion: A QR code-based system could enhance patient care and clinical decision-making; however, it must be relevant, user-friendly in terms of content and format, and address data governance prior to wider implementation.
Dynamics of mid-infrared semiconductor switching controlled by femtosecond laser pulses
Authors: Matteo Daniel , Tochitsky Sergei , Joshi Chan 
Published: January 2025

Semiconductor switching of
sub-picosecond mid-infrared laser pulses between 10 and 14 µm
is characterized in GaAs, n-Ge, and ZnSe controlled by 30 fs
pulses with photon energy above the band gap of the material. The
reflectivity and lifetime are studied for multiple wavelengths. Time
domain dynamics of semiconductor plasma reflectivity observed in
experiments correlate with that derived in diffusion-recombination
theory. Potential application of ultrafast semiconductor switching as
a photonic device for use in high-power mid-infrared laser systems is
discussed.
Sub-nanosecond blue laser at 443  nm using a multi-longitudinal-mode frequency-doubled optical parametric oscillator for oceanic high-spectral-resolution lidar
Authors: Wu Hongda , Chen Feitong , Yuan Mingzhu , Dong Junyang , Sun Wenbo , Hu Miao , Liu Dong , Liu Chong 
Published: January 2025

We have demonstrated a sub-nanosecond frequency-doubled potassium
titanyl phosphate optical parametric oscillator with a large laser
longitudinal mode spacing at 443 nm. Pumped by a
532.2 nm pulsed laser with a pulse width of 0.74 ns and
a maximum pulse energy of 4.08 mJ, the maximum output energy of
a 576 µJ signal laser pulse at 886 nm was successfully
obtained with a short cavity optical length of 8.1 mm; the
corresponding conversion efficiency was up to 14.1%. The signal laser
was frequency-doubled to a deep blue laser at 443 nm with a
longitudinal mode spacing of around 19 GHz, corresponding to
the water molecule Brillouin scattering frequency spacing excited by a
443 nm laser. The spectral linewidth, pulse width, and single
pulse energy of the blue laser were 0.3 nm, 0.5 ns, and
70 µJ, respectively. This is the first demonstration, to the best of our
knowledge, of a sub-nanosecond laser at 443 nm
with such a large longitudinal mode spacing. It provides a reliable
laser source for verifying the feasibility of the
multi-longitudinal-mode laser technique in oceanic
high-spectral-resolution lidar.