bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Iron for Supporting Children’s Growth and Development
Authors: Medise Bernie Endyarni 
Published: June 2021

According to the World Health Organization (WHO), Iron Deficiency (ID) affects around 2 billion people worldwide. Early childhood ID has been associated with permanent cognitive deficits associated with CNS structural, metabolic impairment, growth retardation, impaired immune response, psychological abnormalities, and behavioral delays. This literature review will focus on the important role of iron in child growth and development.
Iron is necessary for various cellular processes in the growing brain especially when it comes to memory and learning. Children with early ID show cognitive deficits that persist; however, prompt iron treatment soothes the problem. A chronic ID group reported substantially lower scores of vocabularies, ambient sound perception, and motor measurements in a recent study relative to infants with normal nutritional iron status at 6 months and 14-18 months. Children's iron requirement differentiates based on individual age. The daily iron requirement for one- to three-year-old children is 7 mg. Some risk factors of infants and toddlers in developing ID are insufficient food intake, poor bioavailability, reduced absorption, increase demand, increase losses, cow’s milk enteropathy hookworm infection, and maternal gestation.
Iron plays an important role in promoting children's growth and development. Physical health and nutrition are important in the first two years of life. Children who are unable to achieve iron adequacy will possibly show permanent cognitive deficit and impaired motor growth. Thus, iron supplementation may only be successful in early prescription after diagnosing iron deficiency.
The Importance of Iron To Support Optimum Cognitive Development
Authors: Sekartini Rini 
Published: June 2021

The fetal brain anatomy development starts during the last trimester of pregnancy and continue in early months of life. This critical process makes it vulnerable to insufficient nutrition, while brain growth continues into adulthood, micronutrient status can affect functioning beyond childhood. Iron is an important nutrient for the production and growth of cells in the immune and neural systems. Iron deficiency (ID) is the most common nutrient deficiency in the world, affecting about half of all pregnant women and their offspring. Iron deficiency anemia has long been believed to have an effect on the central nervous system. Iron deficiency in late trimester and in newborn leads to abnormal cognitive function and emotional control that may continue in adulthood.
In summary, despite some evidence that iron supplementation enhances cognitive performance. Evidence of the role of iron in brain development and the effect of iron deficiency or iron supplementation on early development is uncertain.
Optimizing iron adequacy and absorption to prevent iron deficiency anemia: The role of combination of fortified iron and vitamin C
Authors: W. Basrowi Ray , Dilantika Charisma 
Published: June 2021

Iron is a vital nutrient to promote the availability of tissue oxygen, cell growth and control of differentiation, and energy metabolism. Preventing Iron Deficiency Anemia (IDA) is necessary because iron is vital to central nervous system growth and development especially in the first years of life. Iron-rich complementary foods are recommended in infants around 6 months of age because iron store is depleted. Better understanding of iron absorption process and factors affecting its absorption and bioavailability is necessary to prevent iron deficiency and can be a dietary strategy to mitigate iron deficiency. Meat and iron-fortified food are the main sources of iron in the diet, and it is essential to introduce supplementary food to improve iron absorption. Additional foods such as cereals, cow milk and soybeans such as phytate, polyphenol and calcium are inhibitors which require care to prevent IDA. Ascorbic acid is an effective iron-absorbing enhancer, which is useful to reduce the effects of any known nonheme iron inhibitor. In iron-fortified foods, Combination use of vitamin C (ascorbic acid) is recommended in molar ratio of 2:1 (with cow's milk and low-phytate cereal foods) and higher molar ratio of 4:1 (with higher phytate such as soybeans).
Detection of antimalarial drug resistance polymorphisms in Plasmodium falciparum chloroquine resistance transporter and Plasmodium falciparum multidrug resistance 1 genes of Plasmodium falciparum found in Kano State, Nigeria
Authors: Adamu Al-Mukhtar Yahuza , Olonitola Olayeni Stephen , Inabo Helen Ileigo , Suleiman Ahmad Babangida 
Published: June 2021

Objectives:
In 2018, malaria claimed an estimated 380,000 lives in African region, with Nigeria accounting for 24.0% (91,368) of malaria deaths from the region. Mutations in Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and P. falciparum multidrug resistance 1 (Pfmdr-1) genes had reduced the effective use of artemisinin combination therapy through the development of resistance to these antimalarial agents. Our study set out to determine the antimalarial drug resistance polymorphisms in Pfcrt and Pfmdr-1 genes of P. falciparum isolates among patients in Kano State, Nigeria.

Material and Methods:
Malaria positive samples were collected across the three senatorial districts of Kano State. The samples were amplified using nested polymerase chain reaction to detect the Pfcrt and Pfmdr-1 genes. The amplicons were sequenced and bioinformatic analysis was done using CLC Sequence viewer 8.0 and BioEdit sequence alignment editor to detect the single-nucleotide polymorphisms.

Results:
In the Pfcrt gene, CVIET haplotype was seen in 26.2% of the samples while only two samples showed the 86Y mutation in the Pfmdr-1 gene. All the 86Y mutations and majority of the CVIET haplotypes were detected in the patients from rural settings where some of them noted that they consumed modern and traditional (herbs) antimalarial agents. One sample was observed to have the CVIET haplotype and N86Y mutation while the other five CVIET haplotypes were seen in five separate samples. A new mutation V62A was found in the Pfmdr-1 gene as observed in one of the sample.

Conclusion:
It is imperative to ensure the rational use of the right antimalarial agents and employ continuous resistance surveillance/mapping to ensure synergy in malaria containment and elimination strategies.
Acro-osteolysis in Hajdu Cheney syndrome: A case report with review of literature
Authors: Sethi Humsheer Singh , Sen Kamal Kumar , Mohanty Sudhansu Sekhar , Panda Sangram , Agrawal Akshat , Sharawat Ajay 
Published: June 2021

Objectives:
We present a case report and review the literature on Hajdu Cheney syndrome (HCS), an extremely rare connective tissue disorder with <100 cases reported in the last 72 years. We have emphasized on the patterns of acro-osteolysis (acrosteolysis) in the literature review to conclude if the syndrome follows any particular pattern like in our case.

Material and Methods:
All major databases were searched for all cases of HCS. One hundred and eighty-eight hand radiographs were analyzed and detailed analysis of all digits was carried out with emphasis on the pattern of acrosteolysis.

Results:
Acrosteolysis may not be a mandatory association in HCS as 18.8% did not have acrosteolysis at all. The first finger to be involved in 90/96 (93.7%) of the cases was the index finger, followed by the middle finger and then the thumb. The 4th digit (ring finger) was involved in only 11/96 (11.4%) of the cases, of which 9/11 (81.8%) were above the age of 25. Incidence of acrosteolysis of the 4th digit when in comparison to all other finger has a P < 0.05 and a P < 0.001 with the index finger. Newborn with HCS evaluated for acrosteolysis at birth was negative.

Conclusion:
There was statistical evidence to conclude that in a majority of the cases the 4th digit was involved the least. A rough timeline of the onset and progression of acrosteolysis was made. An attempt was made to shed light on the possible lesser-known manifestations of the syndrome such as retroflexed odontoid, Arnold Chiari I, middle phalanx osteolysis, and first carpometacarpal joint osteolysis. As very little is known about the disease and awareness about it is pertinent for early management and to differentiate it from other less-lethal causes of acrosteolysis.
Knowledge and attitudes of students towards Hansen’s disease: a bibliometric study in national and international literature
Authors: Texeira Elizabeth , Proença Palmeira Iaci , Cardoso Ranieri Bruna , Bezerra de Oliveira Lara 
Published: June 2021

Objetivo: analisar as características das produções sobre conhecimentos e atitudes de estudantes frente à hanseníase nas literaturas nacional e internacional. Método: estudo documental bibliométrico, considerando o período 1990-2019 e as bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE) e Base de Dados da Enfermagem (BDENF), utilizando os descritores e combinações: hanseníase and estudantes, lepra and estudantes. O mapeamento considerou: o perfil das produções; os objetivos; o delineamento do estudo; as conclusões. Resultados: obtiveram-se 17 produções. Quanto ao perfil, oito estavam na língua inglesa, oito em português e uma em espanhol. Quanto aos objetivos, dos cinco domínios segundo a Taxonomia de Bloom, três foram aplicados. Quanto ao delineamento, destacam-se estudos com alunos de cursos da saúde (29,5%), de enfermagem (23,5%), da educação básica (23,5%), de outros cursos universitários (23,5%). Quanto às conclusões, ressaltam-se mais estudos em que se manifestam desconhecimentos e estigmas entre os estudantes. Conclusão: a produção bibliográfica é diversificada quanto às características de perfil, objetivos e delineamento; acentua-se nas conclusões que, mesmo com a presença de desconhecimentos e estigmas entre os estudantes frente à hanseníase, estudos com intervenções educativas possibilitaram mudanças de atitude entre os participantes.
Hospitalizations of older adults due to chronic conditions sensitive to primary care in a Ceará region
Authors: Gabriel Vasconcelos Azevedo Samir , Carvalho Araújo Moreira Andréa , Reis de Carvalho Nathália , Maria Magalhães Moreira Thereza , Lucas Diniz Jamylle , Adelane Monteiro da Silva Maria 
Published: June 2021

Objetivo: analisar a evolução temporal das ICSAP crônicas em idosos e sua correlação com a cobertura da ESF e indicadores socioeconômicos de uma região de saúde. Método: estudo ecológico descritivo, cuja unidade de análise foram os municípios da 11ª Região de Saúde do Ceará no período de 2012 a 2017. Os dados foram extraídos do Sistema de Informação Hospitalar, Sistema de Informação e-Gestor e Atlas de Desenvolvimento Humano no Brasil e analisados no software STATA. Resultados: registradas 7.245 ICSAP, 4.650 (64,18%) pertencem aos grupos de condições crônicas. A maior frequência de internações foi entre os idosos do sexo masculino 2.578 (55,4%) e com idade de 70 a 74 anos com 1.873 (35,87%). As causas mais prevalentes foram: Insuficiência Cardíaca com 1.666 (35,83%), Doenças Cerebrovasculares com 1.048 (22,54%) e Angina com 754 (16,22%). Houve tendência de redução das ICSAP crônicas e expansão da cobertura da ESF com forte correlação inversa (r= -0,80, p-valor =0,0301) e com o índice de Gini (R = 0,80, p = 0,0291). Os demais indicadores socioeconômicos não apresentaram correlação com as taxas de ICSAP. Conclusão: a expansão da cobertura da ESF esteve fortemente correlacionada à redução das taxas de ICSAP crônicas em idosos...
Determining the Role of Hotel Attributes in Building Customer Loyalty Using Importance–Performance Analysis: A Study in the Context of Tourist Nationalities
Authors: Üngüren Engin , Tellioglu Salih , Türker Nazlı 
Published: June 2021

Identifying the importance and satisfaction of hotel attributes in the eyes of tourists and their role in building customer loyalty is critical for improving the service quality. Therefore, in our study, customers' importance and performance perceptions regarding the services offered by accommodation businesses were examined in terms of customers’ nationalities. Our research has two main objectives. The first objective is to determine the importance and performance perceptions of the services provided by the hotels according to the nationalities of the customers using the using importance-performance analysis (IPA) model and to compare the perceptions of importance-performance according to nationality. The second aim is to determine the effect of satisfaction perceptions regarding hotel services on customer loyalty according to customer nationality. The research was designed as a survey-based quantitative research methodology. Convenience sampling was used, which is a non-random sampling method. Data were obtained from 1153 German, Russian, and Turkish tourists accommodating in five-star hotels in Alanya, Turkey. A gap analysis was conducted using pairwise t-tests to evaluate whether the importance and performance perceptions of the participants differed. IPA was conducted with attributes being graphically displayed on the I-P grids. The impact of hotel service satisfaction on customer loyalty was investigated using regression analysis. The research findings reveal that customers' performance perceptions and services attach importance to differ significantly by nationality. And also, it was concluded that satisfaction with the services provided in accommodation businesses has a significant effect on customer loyalty and that this effect differs in customer groups. Determining satisfaction factors affecting customer loyalty according to customer characteristics make a significant contribution to service quality improvement. In this context, the research results provide practical and theoretical contributions to how customer satisfaction and customer loyalty can be improved according to market groups.
Comparison of Short-Term Load Forecasting Based on Kalimantan Data
Authors: Dinata Syalam Ali Wira , Azka Muhammad , Hasanah Primadina , Suhartono Suhartono , Gamal Moh Danil Hendry 
Published: June 2021

This paper investigates a case study on short term forecasting for East Kalimantan, with emphasis on special days, such as public holidays. A time series of load demand electricity recorded at hourly intervals contains more than one seasonal pattern. There is a great attraction in using a modelling time series method that is able to capture triple seasonalities. The Triple SARIMA model has been adapted for this purpose and competitive for modelling load. Using the least squares method to estimate the coefficients in a triple SARIMA model, followed by model building, model assumptions and comparing model criteria, we propose and demonstration the triple Seasonal Autoregressive Integrated Moving Average model with AIC 290631.9 and SBC 290674.2 as the best model for this study. The Triple seasonal ARIMA is one of the alternative strategy to propose accurate forecasts of electricity load Kalimantan data for planning, operation maintenance and market related activities.
Analisis Pengenalan Pola Daun Berdasarkan Fitur Canny Edge Detection dan Fitur GLCM Menggunakan Metode Klasifikasi k-Nearest Neighbor (kNN)
Authors: Paturrahman Azizah Arif , Wijaya I Gede Pasek Suta 
Published: June 2021

Daun merupakan bagian dari tubuh tumbuhan yang dapat digunakan untuk mengidentifikasi jenis dari tumbuhan. Klasifikasi daun ini dapat dilakukan dengan cara pengenalan pola bentuk struktural dan juga tekstur dari citra daun tersebut. Klasifikasi citra daun ini berdasarkan fitur canny edge detection dan fitur GrayLevel Co-occurence Matrix (GLCM) dengan menggunakan metode klasifikasi kNearest Neighbor (kNN). Data yang digunakan sebanyak 350 citra daun dengan 7 spesies yang berbeda. Hasil pengujian yang telah dilakukan dari kedua metode yaitu fitur canny edge detection classifier menghasilkan akurasi 80% dan metode GLCM classifier menghasilkan akurasi 93,3%, serta dilakukannya penggabungan kedua metode menghasilkan akurasi klasifikasi 98%. Sehingga dapat disimpulkan bahwa, dengan dilakukan penggabungan kedua fitur canny edge detection dan GLCM dengan metode klasifikasi kNN menghasilkan akurasi yang baik dalam mengidentifikasi citra daun.
Kata kunci -- daun, canny edge detection, gray-level co-occurence matrix (GLCM), k-nearest neighbor (kNN)
Sífilis em gestantes residentes em São Luís, Maranhão: perfil e evolução de 2006 a 2018
Authors: Fernandes Judriele Francisca Vieira , Pires Rômulo Cesar Rezzo , Cantanhede Andréa Martins , Cordeiro Enndrio Eduardo da Silva 
Published: June 2021

Realizou-se um estudo descritivo com os casos notificados de Sífilis Gestacional (SG) em São Luís (Maranhão) no período de 2006 a 2018. Foram analisadas as tendências de indicadores epidemiológicos pela regressão Joinpoint e as características do agravo com base nos dados do Sistema de Informação de Agravos de Notificação (Sinan). Foram notificados 1.688 casos de SG no período estudado, com tendência significativa de aumento no número de casos novos, na prevalência e no coeficiente de detecção. O perfil das gestantes com SG mostrou que a infecção foi mais frequente em mulheres de 20 a 29 anos, com ensino médio e pardas. Além disso, houve predomínio da forma primária, frequentemente detectada no terceiro trimestre gestacional e tratada com penicilina. A persistência da infecção por sífilis na gestação demonstra uma falha na prevenção de infecções sexuais na população, especialmente na gestação, implicando riscos para e mãe e para o concepto.
Legitimidade de fontes e opinião sobre coronavírus em O Grande Debate
Authors: Costa Juliana , Maia Kênia 
Published: June 2021

A partir do tensionamento de conceitos como objetividade e opinião no jornalismo, polarização espetacularizada e abordagem da saúde pelo jornalismo, o artigo reflete sobre a legitimidade das fontes às quais recorrem os participantes de O Grande Debate, da CNN Brasil. Foram observadas 14 edições do quadro, com o registro das estratégias empregadas pelos comentaristas, a fim de identificar os padrões de legitimidade e de legitimação das fontes. Percebemos que foram acionadas fontes oficiais ou documentais e também fontes falsas ou pseudofontes, contribuindo para a equiparação entre opinião, fato e inverdade nos debates sobre o novo coronavírus.
Interseccionalidade e rupturas dos modos de vida pelos rompimentos de barragem: reflexões a partir de uma mídia em aderência
Authors: Oliveira Simone Santos , Portella Sergio , Katona Laura Luna 
Published: June 2021

É um importante desafio a compreensão do ambiente de violação de direitos a que estão submetidas populações atingidas pelo modelo de desenvolvimento extrativista da mineração. Damos foco aos rompimentos das Barragens de Fundão (Mariana) e Córrego de Feijão (Brumadinho), especialmente às mulheres atingidas – elo menos visível dessa cadeia. Além de enfrentarem desigualdade calcada nas relações interseccionais, imposta pelo capitalismo patriarcal, são as que mais lutam pela reconstrução dos seus modos de vida. O principal esforço deste artigo é dar visibilidade à realidade vivida por essas mulheres, suas redes de solidariedade e luta. Por meio da mídia aderente e alternativa do jornal A Sirene, análise documental e entrevistas, buscamos ouvir as vozes dessas mulheres que têm seus direitos negados e sua saúde comprometida em função do insistente descaso das empresas mineradoras. Utilizando os conceitos trazidos nos estudos de Veena Das, como conhecimento venenoso e sofrimento social, realizamos a análise dos resultados.
Racismo cotidiano na política brasileira: xingamentos e ameaças contra a parlamentar negra Talíria Petrone e seu significado na herança colonial
Authors: Felix Carla Baiense , Paulla Monique 
Published: June 2021

As ameaças e xingamentos racistas direcionados à parlamentar Talíria Petrone, no exercício do seu mandato, expressam a especificidade dos riscos de adoecimento e morte que as mulheres negras enfrentam na política institucional. Partindo do reconhecimento desse fenômeno como uma realidade traumática, como demonstra Kilomba, analisamos os episódios de racismo cotidiano (idem), numa perspectiva interseccional, a partir de uma publicação da deputada no Instagram, e seu significado dentro da herança colonial escravagista brasileira. A análise corrobora a necessidade de plataformas que contemplem e governos que implementem ações efetivas para coibir este tipo de crime e assegurar os direitos políticos e a saúde plena dessas mulheres.
Kesehatan mental mahasiswa ditinjau dari two continua model: Pengujian multiple analysis of variance
Authors: Deasyanti Deasyanti , Muzdalifah Fellianti 
Published: June 2021

Abstract University student’s mental health has to get more attention because they are more vulnerable in suffering psychological problems compared to general population. The aim of this study is to figure out the prevalence of mental health status of students using the two continua model. Mental health symptoms were measured by the MHC-LF that comprised emotional well-being (?= 0,843), psychological well-being (?= 0,807), and social well-being (?= 0,831); whereas psychological distress was identified using the HSCL-25 that measured anxiety (?= 0,910) and depression (?= 0,890). A total of 514 undergraduate students was involved using convenience sampling. The descriptive statistics showed that students are categorised as flourishing 32,10%, moderate mentally healthy 65,95%, and languishing 1,95%. Moreover, the MANOVA test statistics found that there is a significant difference in levels of depression and anxiety between flourishing, moderate mentally healthy and languishing. This study implies that the university should provide the mental health intervention to help students in dealing with psychological distress, and to increase their mental health into flourishing.Keywords: Mental health; Psychological distress; Two continua model; University student. AbstrakIsu kesehatan mental di kalangan mahasiswa perlu mendapat perhatian karena mahasiswa merupakan kelompok populasi yang rentan mengalami masalah psikologis. Dengan menggunakan pendekatan two continua model, penelitian ini bertujuan untuk mengetahui prevalensi tipe kesehatan mental mahasiswa. Indikator sehat mental diukur melalui kuesioner Mental Health Continuum-Long Form yang terdiri dari 3 skala: emotional well-being (?= 0,843), psychological well-being (?= 0,807), dan social well-being (?= 0,831). Indikator psikopatologis diukur menggunakan skala Hopkins Symptom Check List-25 yang terdiri dari skala kecemasan (?= 0,910) dan skala depresi (?= 0,890). Sebanyak 514 mahasiswa menjadi responden dalam penelitian ini menggunakan teknik sampling convenience. Dengan analisis statistik deskriptif diketahui 32.10% mahasiswa termasuk dalam kategori sehat mental flourishing, 66,95% moderate mentally healthy dan 1,95% languishing. Uji statistik MANOVA menemukan perbedaan tingkat kecemasan dan depresi antara kelompok sehat mental yang berbeda. Implikasi hasil penelitian ini terkait dengan program intervensi kesehatan mental mahasiswa yang bersifat kuratif, protektif, maupun promotif untuk meningkatkan keberfungsian psikologis secara lebih optimal. Kata kunci: Distres psikologis; Mahasiswa; Sehat mental; Two Continua Model