bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wireless Power Delivery Techniques for Miniature Implantable Bioelectronics
Authors: Singer Amanda , Robinson Jacob T. 
Published: June 2021

AbstractProgress in implanted bioelectronic technology offers the opportunity to develop more effective tools for personalized electronic medicine. While there are numerous clinical and pre‐clinical applications for these devices, power delivery to these systems can be challenging. Wireless battery‐free devices offer advantages such as a smaller and lighter device footprint and reduced failures and infections by eliminating lead wires. However, with the development of wireless technologies, there are fundamental tradeoffs between five essential factors: power, miniaturization, depth, alignment tolerance, and transmitter distance, while still allowing devices to work within safety limits. These tradeoffs mean that multiple forms of wireless power transfer are necessary for different devices to best meet the needs for a given biological target. Here six different types of wireless power transfer technologies used in bioelectronic implants—inductive coupling, radio frequency, mid‐field, ultrasound, magnetoelectrics, and light—are reviewed in context of the five tradeoffs listed above. This core group of wireless power modalities is then used to suggest possible future bioelectronic technologies and their biological applications.
Imparting Antimicrobial and Antifouling Properties to Anion Exchange Membrane through the Modification with Gentamicin‐Based Polymer
Authors: Luo Bin , Yao Yuyang , Liao Junbin , Chen Quan , Ruan Huimin , Shen Jiangnan 
Published: June 2021

AbstractA series of gentamicin‐modified anion exchange membranes (AEMs) immobilized by mussel‐inspired dopamine coating is prepared in this work. The purpose is to improve antibacterial activity and fouling resistance of the commercial AEMs (AEM Type I, Fujifilm Co.). As a result of the applied modification, the hydrophilicity of membrane surface improved significantly. Thus, the as‐prepared modified AEMs exhibit the good antifouling property, in electrodialysis (ED) experiments by using the sodium dodecylbenzenesulfonate and albumin from bovine serum as model foulants. Furthermore, taking into account the results of the antibacterial test, the resulting modified AEMs exhibit improved antibacterial property for Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). After a brief contact with bacteria, the antibacterial rates of modified AEMs coating with gentamicin‐based polymer are 80.11% for E. coli and 90.66% for S. aureus, which are much higher than pristine AEM (6.28% and 9.07%), respectively. In addition, the modified membrane has good operational stability during ED process and recovery ability after contamination, and also maintains satisfactory electrochemical properties. This investigation highlights a design of simple strategy for the preparation of antimicrobial and antifouling AEM, which can be used for ED.
3D‐Printed Terahertz Topological Waveguides
Authors: Khan Muhammad Talal Ali , Li Haisu , Duong Nathan Nam Minh , Blanco‐Redondo Andrea , Atakaramians Shaghik 
Published: June 2021

AbstractCompact and robust waveguide chips are crucial for new integrated terahertz (THz) applications, such as high‐speed interconnections between processors and broadband short‐range wireless communications. Progress on topological photonic crystals shows potential to improve integrated terahertz systems that suffer from high losses around sharp bends. Robust terahertz topological transport through sharp bends on a silicon chip has recently been reported over a relatively narrow bandwidth. Here, the experimental demonstration of topological terahertz planar air‐channel metallic waveguides, which are able to integrate functional components inside the chip, is reported. This platform is fabricated by a simple, cost‐effective technique combining 3D‐printing and gold sputtering. The relative size of the measured topological bandgap is ≈12.5%, which entails significant improvement (≈60%) over all‐silicon terahertz topological waveguides (≈7.8%). Robust THz propagation around defects and delay lines is further demonstrated. This work provides a promising path toward compact integrated terahertz devices as a next frontier for advanced terahertz systems such as wireless communications.
Direct Conversion of Alginate Oligo‐ and Polysaccharides into Biodegradable and Non‐Ecotoxic Anionic Furanic Surfactants—An Experimental and Mechanistic Study
Authors: Renault Louise , Marchal Rémi , Le Guennic Boris , Roussel Xavier , Divet Pierre‐Yves , Benvegnu Thierry 
Published: June 2021

AbstractA series of novel anionic furanic surfactants characterized by the presence of a couple of lipophilic chains acetal‐linked to a sodium 2‐furoate head group, are prepared by the conversion of oligo‐alginates or alginate to butyl 5‐(dibutoxymethyl)‐2‐furoate, followed by the introduction of fatty alkyl chains containing 7 to 18 carbon atoms and the release of the carboxylate function. A plausible mechanism for the unexpected formation of butyl 5‐(dibutoxymethyl)‐2‐furoate is proposed through a study based on both experimental results and density functional calculations. One‐pot processes involving hydrolysis, butanolysis, dehydration, transesterification, transacetalization, and saponification reactions, are successfully developed to provide furan‐type surfactants under conditions that respect the principles of green chemistry. The surface activities of these products in a pure form or as a mixture are evaluated and quite low values of superficial tensions (<25 mN m−1) and foaming properties are obtained depending on the alkyl chain length. In addition, a readily biodegradability and an absence of aquatic ecotoxicity are shown for a surfactant composition based on sodium 5‐(dioctyloxymethyl)‐2‐furoate.
Boosting the Oxidative Potential of Polyethylene Glycol‐Based Polymer Electrolyte to 4.36 V by Spatially Restricting Hydroxyl Groups for High‐Voltage Flexible Lithium‐Ion Battery Applications
Authors: Fang Zhenhan , Luo Yufeng , Liu Haitao , Hong Zixin , Wu Hengcai , Zhao Fei , Liu Peng , Li Qunqing , Fan Shoushan , Duan Wenhui , Wang Jiaping 
Published: June 2021

AbstractCross‐linked polyethylene glycol‐based resin (c‐PEGR) is constructed by a ring‐opening reaction of polyethylene glycol diglycidyl ether (PEGDE) with epoxy groups and polyether amine (PEA) with amino groups. By confining the hydroxyl groups with inferior oxidative stability to the c‐PEGR backbone, the oxidation potential of the PEG‐based polymer material with reduced reactivity is boosted to 4.36 V. The c‐PEGR based gel electrolyte shows excellent flexibility, lithium‐ion transport, lithium compatibility, and enhanced oxidation stability, and is successfully applied to a 4.35 V lithium cobaltate (LCO)||lithium (Li) battery system. A quasi‐static linear scanning voltammetry (QS‐LSV) method is proposed for the first time to accurately measure the oxidation potential and electrochemical stability window of materials with low conductivities such as polymers, which possesses the advantages of high accuracy and short test time. This work provides new insights and research techniques for selecting polymer electrolytes for high‐voltage flexible lithium‐ion batteries (LIBs).
In Situ Lattice Tunnel Distortion of Vanadium Trioxide for Enhancing Zinc Ion Storage
Authors: Ding Junwei , Zheng Huaiyang , Gao Hongge , Liu Qiannan , Hu Zhe , Han Lifeng , Wang Shiwen , Wu Shide , Fang Shaoming , Chou Shulei 
Published: June 2021

AbstractResearch on aqueous zinc‐ion batteries is still in its initial stages owing to the limited choice of cathode materials, especially those having tunnel structures with high capacity and fast kinetics. Furthermore, their zinc ion storage mechanisms are not well established as yet. Here, a novel in situ electrochemical lattice distortion of vanadium trioxide (V2O3) is demonstrated. The obtained defect‐rich V2O3 is applied as a cathode for ultrafast Zn2+ storage. Operando X‐ray diffraction and operando Raman spectroscopy corroborate the unique lattice conversion reaction of V2O3 during the initial charging process. Transmission electron microscopy and X‐ray photoelectron spectroscopy further demonstrate the stability of the main crystal planes of V2O3 during the initial lattice distortion and subsequent zinc ion storage processes. This unique in situ electrochemical lattice conversion reaction allows V2O3 to achieve a high capacity of 382.5 mAh g−1, remarkable rate performance (154.3 mAh g−1 at 51.2 A g−1), and high energy and power densities (139 Wh kg−1 at 46 KW kg−1), revealing the potential of tunnel‐type cathodes via an in situ electrochemical lattice distortion reaction to achieve ultrafast zinc ion storage with high capacity.
Identification and Evaluation of Serum Protein Biomarkers That Differentiate Psoriatic Arthritis From Rheumatoid Arthritis
Authors: Mc Ardle Angela , Kwasnik Anna , Szentpetery Agnes , Hernandez Belinda , Parnell Andrew , de Jager Wilco , de Roock Sytze , FitzGerald Oliver , Pennington Stephen R. 
Published: June 2021

ObjectiveTo identify serum protein biomarkers that might distinguish patients with early inflammatory arthritis (IA) with psoriatic arthritis (PsA) from those with rheumatoid arthritis (RA) and may be used to support appropriate early intervention.MethodsThe serum proteome of patients with PsA and patients with RA was interrogated using nano–liquid chromatography mass spectrometry (nano‐LC‐MS/MS) (n = 64 patients), an aptamer‐based assay (SomaScan) targeting 1,129 proteins (n = 36 patients), and a multiplexed antibody assay (Luminex) for 48 proteins (n = 64 patients). Multiple reaction monitoring (MRM) assays were developed to evaluate the performance of putative markers using the discovery cohort (n = 60 patients) and subsequently an independent cohort of PsA and RA patients (n = 167).ResultsMultivariate machine learning analysis of the protein discovery data from the 3 platforms revealed that it was possible to differentiate PsA patients from RA patients with an area under the curve (AUC) of 0.94 for nano‐LC‐MS/MS, 0.69 for bead‐based immunoassay measurements, and 0.73 for aptamer‐based analysis. Subsequently, in the separate verification and evaluation studies, random forest models revealed that a subset of proteins measured by MRM could differentiate PsA and RA patients with AUCs of 0.79 and 0.85, respectively.ConclusionWe present a serum protein biomarker panel that can separate patients with early‐onset IA with PsA from those with RA. With continued evaluation and refinement using additional and larger patient cohorts, including those with other arthropathies, we suggest that the panel identified here could contribute to improved clinical decision making.
Triple‐Layered Metal‐Organic Framework Hybrid for Tandem Response‐Driven Enhanced Chemotherapy
Authors: Wang Fang , Huang Jing , Xin Hao , Lei Jianping 
Published: June 2021

AbstractThe precise release of drugs is essential to improve cancer therapeutic efficacy. In this work, a tandem responsive strategy was developed based on a triple‐layered metal‐organic framework (MOF) hybrid. The MOF nanoprobe was stepwise fabricated with a telomerase‐responsive inner, a pH‐sensitive MOF filling and H2O2‐responsive coordination complex shell of Fe3+ and eigallocatechin gallate (EGCG). In the tumor microenvironment, the shell was dissociated by endogenous H2O2 and simultaneously produced highly reactive hydroxyl radicals by a Fenton reaction. Meanwhile, the released EGCG could downregulate the expression of P‐glycoprotein responsible for drug resistance. After the dissociation of the framework by protons, telomerase could trigger the release of the drug from the DNA duplex on the exposed inner shell. By integrating confined drug release, inhibited efflux pump and chemodynamic therapy, the all‐in‐one chemotherapy strategy was identified with enhanced therapeutic efficacy in drug‐resistant cancer cells.
Lead service line identification: A review of strategies and approaches
Authors: Hensley Kelsey , Bosscher Valerie , Triantafyllidou Simoni , Lytle Darren A. 
Published: June 2021

AbstractLead service lines (LSLs) represent the greatest source of lead in drinking water. Identifying the locations of LSLs can be challenging, and recent service line (SL) material surveys in Michigan, Illinois, Wisconsin, and Indiana found that on average the materials making up 16% of SLs in these states are unknown and may be lead. Given the large number of possible LSLs in the United States, new and pending regulatory requirements, LSL replacement costs, associated lead exposure risks, and the public's desire to reduce lead exposure, there is a need to rapidly and cost‐effectively identify where LSLs are located, on public and private property. This review summarizes current industry LSL identification methods, including records screening, basic visual examination of indoor plumbing, water sampling, excavation, and predictive data analyses. A qualitative comparison of method cost, accuracy, disturbance, and other impacts is provided as a starting point for utilities that are developing a feasible approach for their specific needs/constraints. Lastly, an example stepwise approach to identify unknown SL materials is proposed.Article Impact StatementThis manuscript provides water systems with a review of techniques available to identify LSLs.
Biosynthesized silver nanoparticle–coated electro‐membrane extraction of perchlorate in different seafood samples
Authors: Mousa Amayreh , Basheer Chanbasha , Abdullah Mohanad , Al‐Rimawi Fuad 
Published: June 2021

AbstractIn this work we developed a rapid and straightforward technique in which biosynthesized silver nanoparticles (Ag‐NPs) were coated on a porous membrane utilizing electrical potential to extract perchlorate from seafood samples. The biosynthesized Ag‐NPs were well characterized using UV–Vis. spectrophotometry, X‐ray diffraction, and scanning electron microscopy. After extraction, analyses were performed using ion chromatography. The Ag‐NP‐coated porous polypropylene membrane shows higher extraction efficiency due to the high electrical conductivity of the Ag‐NPs. The performance of this efficient technique was compared with those previously reported in the literature. The extraction variables that affect extraction of the target analyte and influence percentage recovery, such as pH of the sample solution, extraction time, and applied voltage, were investigated and optimized. The results demonstrated optimum conditions to achieve low detection limits [LODs (limits of detection)]: sample solution (pH = 6), short extraction time (10 min), and applied voltage (5 V). The developed method shows excellent linearity for perchlorate ion in the range from 0.001 to 350 μg L−1 with a coefficient of determination (r2) of 0.9991. The detection limit (LODs) and quantification limits (limits of quantification) were found to be 0.04 and 0.1225 μg kg−1, respectively. The mean recovery percentages for three replicates of 10 different spiked fish samples by 3 μg g−1 of perchlorate were between 92.2 and 106.2%, with an observed relative standard deviation in the range of 0.8–3.7%. The proposed method is rapid, sensitive, inexpensive, environmentally friendly, and highly effective in extracting perchlorate from different seafood samples.
Bleeding complications in patients with gastrointestinal cancer and atrial fibrillation treated with oral anticoagulants
Authors: Ording Anne Gulbech , Søgaard Mette , Skjøth Flemming , Grove Erik Lerkevang , Lip Gregory Y. H. , Larsen Torben Bjerregaard , Nielsen Peter Brønnum 
Published: June 2021

AbstractBackgroundDirect oral anticoagulants (DOACs) may increase the risk of gastrointestinal (GI) bleeding in patients with atrial fibrillation (AF) and GI cancer compared with vitamin K antagonists (VKA).MethodsWe conducted a Danish nationwide cohort study comparing the bleeding risk associated with DOAC versus VKA in patients with AF and GI cancer. We calculated crude bleeding rates per 100 person‐years (PYs) for GI and major bleeding. We then compared rates of bleeding at 1 year after initial oral anticoagulation filled prescription by treatment regimen using inverse probability of treatment weighting and Cox regression.ResultsThe unweighted study population included 1476 AF patients with GI cancer (41.6% women, median age 78 years) initiating a DOAC and 652 initiating a VKA. One‐year risk of GI bleeding was 5.0% in the DOAC group and 4.7% in the VKA group with a corresponding weighted hazard ratio (HR) of 0.95 (95% confidence interval [CI]: 0.63, 1.45). For patients with active cancer, weighted GI bleeding rates were slightly higher in both the VKA and DOAC group, and the weighted HR was 1.00 (95% CI: 0.53, 1.88). The HR was 1.12 (95% CI: 0.71, 1.76) for all bleedings. Hazard ratios for GI bleeding were 0.61 (95% CI: 0.25, 1.52) for patients with upper GI cancer, and 0.92 (95% CI: 0.58, 1.46) in patients with colorectal cancer.ConclusionEvidence from this nationwide cohort study suggests a comparable 1‐year risk of bleeding associated with DOAC compared with VKA among patients with AF and GI cancer.
Gods, germs, and science: Unraveling the role of scientific literacy, germ aversion, and religious fundamentalism in predicting attitudes towards gays and lesbians
Authors: Hudiyana Joevarian , Prawira Benny , Kartika Dyah Ayu , Mahendra Dimas , Putra Idhamsyah Eka 
Published: June 2021

AbstractPrior studies suggest that scientific knowledge may improve attitudes towards sexual minorities such as gays and lesbians. But in what context does this ring true? The present study aims to test whether scientific literacy can predict attitudes towards gays and lesbians when considering the variables pathogen avoidance and religious fundamentalism in a moderated moderation model. A total of 1,398 participants (female = 74.9%, Mage = 25.15,SD = 5.84) completed our online survey. We found that an increase in scientific literacy can indeed predict an improvement in attitudes towards sexual minorities, specifically gays and lesbians. However, this effect was weakened in the condition of high pathogen avoidance, specifically for one of the dimensions of pathogen avoidance—germ aversion. When considering the value of religious fundamentalism in a three‐way interaction, we found that scientific literacy can remain effective in predicting attitudes towards sexual minorities only within the condition of low germ aversion. Thus, threat avoidance such as germ aversion, contrary to religious fundamentalism, may diminish the benefits of scientific literacy in improving attitudes towards sexual minorities. Please refer to the Supplementary Material section to find this article'sCommunity and Social Impact Statement.
Biology educators, professional societies, and practitioner networks within community colleges
Authors: Holmberg Tara Jo , Gusky Sharon , Kiser Stacey , Karpakakunjaram Vedham , Seitz Heather , Fletcher Linnea , Fields Lindsey , Nenortas Apryl , Corless Andrew , Marcos Katrina 
Published: June 2021

AbstractCommunity college biology faculty play an important role in educating the future STEM workforce. These faculty rely on professional organizations to provide programming and networking opportunities to enhance their professional development.
Voltammetry of Several Natural and Synthetic Opioids at a Polarized Ionic Liquid Membrane
Authors: Langmaier Jan , Maier Vítězslav , Samec Zdeněk 
Published: June 2021

AbstractCyclic voltammetry is used to examine the transfer of the protonated forms of several natural and synthetic opioids including fentanyl and its analogs, morphine, heroin and codeine, across the polarized interface between an aqueous electrolyte solution and an ionic liquid (IL) membrane. Besides demonstrating the possibility of an amperometric detection and determination, the voltammetric measurements provide the values of the ion partition coefficients and the standard Gibbs energy of ion transfer, along with the partition coefficients for the neutral opioids, which follow the sequence corresponding to the opioid analgesic potency. A correlation between the partition coefficients for the neutral and protonated opioids points to their common basis, which is the difference between the solvation energies of the partitioned species in water and IL phase. A comparison of the experimental and theoretical values of the standard Gibbs energy of ion transfer suggests that the solvophobic interactions play a key role.
Do adverse health shocks induce myopic financial planning?
Authors: Streeter Jialu L. 
Published: June 2021

AbstractHealth and financial planning have both been found to be crucial to long‐term financial stability. However, the impact of a health shock on financial planning horizon was not directly tested. This article traces the trajectories of the financial planning horizon before and after the occurrence of work‐limiting health shocks, using longitudinal panel data from the Health and Retirement Study. Results show that, during the 10 years following a health shock, individuals are 20 to 39% more likely to focus on the near term (i.e., the next few months) than baseline levels. Moreover, people with lower socioeconomic status or poor general health are more prone to switching to myopic planning after a health shock.
Application Potential of Membrane Processes in the Concept of Lignocellulose Biorefineries
Authors: Lipnizki Frank , Rudolph Gregor , Thuvander Johan , Al‐Rudainy Basel , Vives Mariona Battestini 
Published: June 2021

AbstractDie Zellstoff‐ und Papierindustrie ist einer der wichtigsten Industriesektoren weltweit und hat großes Potenzial, ein Eckpfeiler für die zukünftige Bioökonomie zu sein, insbesondere für Lignocellulose‐Bioraffinerien. Das Potenzial von Membranverfahren bei dieser Umwandlung wird in drei Beispielen aus dem Bereich Kraft/Sulfat, Sulfit und thermomechanischem Aufschluss dargestellt. Darüber hinaus werden die Herausforderungen von Membranverschmutzung und ‐reinigung im Hinblick auf die Zellstoffindustrie erörtert und ein Ausblick auf zukünftige Entwicklungen von Membranen in Bioraffinerien gegeben.
A Novel Minor Groove Binder as a Potential Therapeutic Agent for Myotonic Dystrophy Type 1
Authors: Li Ke , Krueger Sarah B. , Zimmerman Steven C. 
Published: June 2021

AbstractMyotonic dystrophy type 1 (DM1) is a multisystemic neuromuscular disorder that is inherited in an autosomal dominant manner. DM1 originates in a (CTG⋅CAG) repeat expansion in the 3’‐UTR of the dystrophia myotonic protein kinase (DMPK) gene on chromosome 19. One of the transcripts, r(CUG)exp, is toxic in various ways. Herein we report a rationally designed small molecule with a thiazole peptidomimetic unit that can serve as a minor groove binder for the nucleic acid targets. This peptide unit linked to two triaminotriazine recognition units selectively binds to d(CTG)exp to inhibit the transcription process, and also targets r(CUG)exp selectively to improve representative DM1 pathological molecular features, including foci formation and pre‐mRNA splicing defects in DM1 model cells. As such, it represents a new structure type that might serve as a lead compound for future structure‐activity optimization.