bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of elevated creatine phosphokinase between daptomycin alone and concomitant daptomycin and statins: A systematic review and meta‐analysis
Authors: Samura Masaru , Takada Keisuke , Hirose Naoki , Kurata Takenori , Nagumo Fumio , Koshioka Sakura , Ishii Junichi , Uchida Masaki , Inoue Junki , Enoki Yuki , Taguchi Kazuaki , Tanikawa Koji , Matsumoto Kazuaki 
Published: December 2021

AimsThe present systematic review and meta‐analysis evaluated the incidence of elevated creatine phosphokinase (CPK) levels between daptomycin alone and concomitant daptomycin and statin use.MethodsWe searched the PubMed, Web of Sciences, Cochrane Library and ClinicalTrials.gov databases. We analysed the incidence of elevated CPK between daptomycin alone and concomitant daptomycin and statins among studies defining CPK elevation as levels ≥ the upper limit of normal (ULN) or ≥5× ULN. We also analysed the incidence of rhabdomyolysis between the groups. We then calculated the odds ratios (ORs) and 95% confidence intervals (CIs) based on the included studies.ResultsComparing CPK elevation defined as CPK levels ≥ULN, a significantly higher incidence of CPK elevation was observed with concomitant daptomycin and statin use than with daptomycin alone (OR = 2.55, 95% CI 1.78–3.64, P < .00001, I2 = 0%). Likewise, when CPK elevation was defined as CPK levels ≥5× ULN, a significantly higher incidence of CPK elevation was detected with concomitant daptomycin and statin use than with daptomycin alone (OR = 1.89, 95% CI 1.06–3.35, P = .03, I2 = 48%). The incidence of rhabdomyolysis was significantly higher following concomitant daptomycin and statin use than with daptomycin alone (OR = 11.60, 95% CI 1.81–74.37, P = .01, I2 = 0%).ConclusionThe combined use of daptomycin and statins were significant risk factors for the incidence of CPK elevation defined as levels ≥ULN or ≥5× ULN and rhabdomyolysis.
Daily fluctuations in young children’s persistence
Authors: Leonard Julia A. , Lydon‐Staley David M. , Sharp Sophie D. S. , Liu Hunter Z. , Park Anne T. , Bassett Danielle S. , Duckworth Angela L. , Mackey Allyson P. 
Published: December 2021

AbstractChildren's behavior changes from day to day, but the factors that contribute to its variability are understudied. We developed a novel repeated measures paradigm to study children's persistence by capitalizing on a task that children complete every day: toothbrushing (N = 81; 48% female; 36–47 months; 80% white, 14% Multiracial, 10% Hispanic, 2% Asian, 1% Black; 1195 observations collected between January 2019 and March 2020). Children brushed longer on days when their parents used more praise (d = .23) and less instruction (d = −.22). Sensitivity to mood, sleep, and parent stress varied across children, suggesting that identifying the factors that shape an individual child's persistence could lead to personalized interventions.
An unusual case of tertiary syphilis
Authors: Ha-bu-lie-ti Xia-er-ba-ti , Wang Ling-ling , Zhu Ya-lin 
Published: December 2021

Abstract
We report a rare case of tertiary syphilis in a middle aged man who presented with a 6-month history of ulceration of his left eye with extreme pain. Physical examination revealed fistulas, granuloma with ulcer, and corneal opacity with granulomatous conjunctivitis in the left eye. Based on the patient's clinical manifestations and auxiliary examination results, neurosyphilis was diagnosed.
BMPER alleviates ischemic brain injury by protecting neurons and inhibiting neuroinflammation via Smad3‐Akt‐Nrf2 pathway
Authors: Ding Peng , Chen Wei , Yan Xiaodi , Zhang Jinxiang , Li Cheng , Zhang Guangming , Wang Yongqiang , Li Yonghua 
Published: December 2021

AbstractAimsBone morphogenetic proteins (BMPs) are a group of proteins related to bone morphogenesis. BMP‐binding endothelial regulator (BMPER), a secreted protein that interacts with BMPs, is known to be involved in ischemic injuries. Here, we explored the effects of BMPER on cerebral ischemia and its mechanism of action.MethodsA mouse model of brain ischemia was induced by middle cerebral artery occlusion (MCAO). An in vitro ischemic model was established by subjecting primary cultured neurons to oxygen‐glucose deprivation/reperfusion (OGD/R). Serum levels of BMPs/BMPER were measured in MCAO mice and in patients with acute ischemic stroke (AIS). Brain damages were compared between BMPER‐ and vehicle‐treated mice. Quantitative polymerase chain reaction (qPCR), immunohistochemistry, and immunofluorescence staining were performed to examine neuroinflammation and cell death. BMPER‐related pathways were assessed by Western blotting.ResultsBMPER level was elevated in MCAO mice and AIS patients. BMPER administration reduced mortality, infarct size, brain edema, and neurological deficit after MCAO. Neuroinflammation and cell death after ischemia were alleviated by BMPER both in vivo and in vitro. BMPER activated the Smad3/Akt/Nrf2 pathway in OGD/R‐challenged neurons.ConclusionBMPER is a neuroprotective hormone that alleviates ischemic brain injury via activating the Smad3/Akt/Nrf2 pathway. These findings may provide potential therapeutic strategies for stroke.
A global community‐sourced assessment of the state of conservation technology
Authors: Speaker Talia , O'Donnell Stephanie , Wittemyer George , Bruyere Brett , Loucks Colby , Dancer Anthony , Carter Marianne , Fegraus Eric , Palmer Jonathan , Warren Ellie , Solomon Jennifer 
Published: December 2021

AbstractConservation technology holds the potential to vastly increase conservationists’ ability to understand and address critical environmental challenges, but systemic constraints appear to hamper its development and adoption. Understanding of these constraints and opportunities for advancement remains limited. We conducted a global online survey of 248 conservation technology users and developers to identify perceptions of existing tools’ current performance and potential impact, user and developer constraints, and key opportunities for growth. We also conducted focus groups with 45 leading experts to triangulate findings. The technologies with the highest perceived potential were machine learning and computer vision, eDNA and genomics, and networked sensors. A total of 95%, 94%, and 92% respondents, respectively, rated them as very helpful or game changers. The most pressing challenges affecting the field as a whole were competition for limited funding, duplication of efforts, and inadequate capacity building. A total of 76%, 67%, and 55% respondents, respectively, identified these as primary concerns. The key opportunities for growth identified in focus groups were increasing collaboration and information sharing, improving the interoperability of tools, and enhancing capacity for data analyses at scale. Some constraints appeared to disproportionately affect marginalized groups. Respondents in countries with developing economies were more likely to report being constrained by upfront costs, maintenance costs, and development funding (p = 0.048, odds ratio [OR] = 2.78; p = 0.005, OR = 4.23; p = 0.024, OR = 4.26), and female respondents were more likely to report being constrained by development funding and perceived technical skills (p = 0.027, OR = 3.98; p = 0.048, OR = 2.33). To our knowledge, this is the first attempt to formally capture the perspectives and needs of the global conservation technology community, providing foundational data that can serve as a benchmark to measure progress. We see tremendous potential for this community to further the vision they define, in which collaboration trumps competition; solutions are open, accessible, and interoperable; and user‐friendly processing tools empower the rapid translation of data into conservation action.Article impact statement: Addressing financing, coordination, and capacity‐building constraints is critical to the development and adoption of conservation technology.
Insights into roles of METTL14 in tumors
Authors: Liu Xin , Du Yuping , Huang Zhenghao , Qin Honglei , Chen Jingwen , Zhao Yang 
Published: December 2021

AbstractN6‐Methyladenosine (m6A) is considered the most common and endogenous modification of eukaryotic RNAs. Highly conserved in many species, m6A regulates RNA metabolism, cell differentiation, cell circadian rhythm, and cell cycle; it also responds to endogenous and exogenous stimuli and is associated with the development of tumors. The m6A methyltransferase complex (MTC) regulates the m6A modification of transcripts and involves two components, methyltransferase‐like enzyme 3 (METTL3) and methyltransferase‐like enzyme 14 (METTL14), and other auxiliary regulatory distinct components. Though with no catalytic effect, METTL14 serves as an RNA‐binding scaffold in MTC, promotes RNA substrate recognition, activates, and escalates the catalytic capability of METTL3, thus accounting for a pivotal member of the complex. It was reported that METTL14 regulates tumor proliferation, metastasis, and self‐renewal, and plays a part in tumorigenesis, tumor progression, and other processes. The present work is a review of the role of METTL14 both as a tumor suppressor and a tumor promoter in the oncogenesis and progression of various tumors, as well as the potential molecular mechanisms.
A systematic review and meta‐analysis of the association between emotional stress reactivity and psychosis
Authors: Muddle Sarah , Jones Bradley , Taylor Gemma , Jacobsen Pamela 
Published: December 2021

AbstractAimEmotional stress reactivity may be a mediating factor in the association between trauma and psychosis. This review aimed to (i) identify, summarise and critically evaluate the link between emotional stress reactivity and psychotic experiences (ii) examine evidence for a 'dose–response' relationship between stress reactivity and psychosis in the wider psychosis phenotype (i.e., sub‐clinical symptoms).MethodsElectronic database searches (PsychINFO, MEDLINE, EMBASE) were conducted for studies which investigated the link between stress reactivity and psychosis, psychotic symptoms, or a vulnerability to developing psychosis (wider phenotype). Cross‐sectional, experimental and experience sampling method study designs were eligible for inclusion.ResultsFourty five eligible articles were identified (N participants = 8830). Narrative synthesis showed that increased emotional stress reactivity was associated with psychosis and subclinical psychotic experiences across all study designs, however, findings were inconsistent across studies. The preliminary meta‐analysis (k = 4, n = 383) showed increases in emotional stress reactivity was associated with higher negative affect in response to event‐related stress, in those with psychosis compared to controls (mean difference in beta coefficients = 0.05, 95% CI 0.02–0.08, p = .004). However, this difference was small with a considerable degree of heterogeneity (p = .001, I2 = 81%) so results should be interpreted with caution.ConclusionsOverall, the evidence suggests that there is a link between emotional stress reactivity and psychosis in those with psychosis, those at high risk of developing psychosis and in relation to subclinical psychotic‐like experiences in the general population.
Anti‐thymocyte Globulin and Post‐Transplant Cyclophosphamide do not abrogate the inferior outcome risk conferred by human leukocyte antigen‐A and ‐B mismatched donors
Authors: Novitzky‐Basso Igor , Remberger Mats , Chen Carol , Ellison Cynthia , Pasic Ivan , Lam Wilson , Law Arjun , Gerbitz Armin , Viswabandya Auro , Lipton Jeffrey H. , Kim Dennis D. , Kumar Rajat , Michelis Fotios V. , Mattsson Jonas 
Published: December 2021

AbstractIn donor selection for allogeneic stem cell transplant, several factors are considered for potential impact on transplant outcome. Previous publications suggested single HLA‐mismatched unrelated donors (MMUD) may be equivalent to 10/10 matched unrelated donors (MUDs). We retrospectively examined factors affecting outcome in a single‐center study using ATG followed by post‐transplant cyclophosphamide, termed ATG‐PTCy, GvHD prophylaxis. Fifty‐two patients who received grafts from MMUD and 188 patients transplanted from MUD between January 2015 and December 2019, at Princess Margaret Cancer Centre, Canada, were enrolled. All patients received reduced‐intensity conditioning. Overall survival for 9/10 recipients at 2 years was significantly worse, 37.2% versus 68.5% for 10/10 MUDs, p < .001, as were NRM at 1 year 39.5% versus 11.7%, p < .001, and GRFS at 2 years 29.8% versus 58.8%, p < .001, respectively, potentially due to higher incidence of infections including CMV. By multivariable analysis, factors correlating with survival negatively were DRI, and MMUD, whereas for NRM MMUD and increasing age were unfavorable. For GRFS significant unfavorable factors included donor age ≤32 years, female donor to male recipient, DRI high‐very high and MMUD. These data suggest that MMUD, primarily HLA‐A and HLA‐B MMUD, confer significantly inferior outcome despite use of ATG‐PTCy. Further development of novel conditioning regimens and GvHD prophylaxis is needed to mitigate these risks.
Time to move: Brain dynamics underlying natural action and cognition
Authors: De Sanctis Pierfilippo , Solis‐Escalante Teodoro , Seeber Martin , Wagner Johanna , Ferris Daniel P. , Gramann Klaus 
Published: December 2021

AbstractAdvances in Mobile Brain/Body Imaging (MoBI) technology allows for real‐time measurements of human brain dynamics during every day, natural, real‐life situations. This special issue Time to Move brings together a collection of experimental papers, targeted reviews and opinion articles that lay out the latest MoBI findings. A wide range of topics across different fields are covered including art, athletics, virtual reality, and mobility. What unites these diverse topics is the common goal to enhance and restore human abilities by reaching a better understanding on how cognition is implemented by the brain‐body relationship. The breadth and novelty of paradigms and findings reported here positions MoBI as a new frontier in the field of human cognitive neuroscience.
Bioactive lipids and their metabolism: New therapeutic opportunities for Parkinson's disease
Authors: Shen Wenjing , Jiang Li , Zhao Jingyi , Wang Haili , Hu Meng , Chen Lanlan , Chen Yingzhu 
Published: December 2021

AbstractParkinson's disease (PD) is a neurological disorder characterized by motor dysfunction, which can also be associated with non‐motor symptoms. Its pathogenesis is thought to stem from a loss of dopaminergic neurons in the substantia nigra pars compacta and the formation of Lewy bodies containing aggregated α‐synuclein. Recent works suggested that lipids might play a pivotal role in the pathophysiology of PD. In particular, the so‐called ‘bioactive’ lipids whose changes in the concentration may lead to functional consequences and affect many pathophysiological processes, including neuroinflammation, are closely related to PD in terms of symptoms, disease progression and incidence. This study aimed to explore the molecular metabolism and physiological functions of bioactive lipids, such as fatty acids (mainly unsaturated fatty acids), eicosanoids, endocannabinoids, oxysterols, representative sphingolipids, diacylglycerols and lysophosphatidic acid, in the development of PD. The knowledge of bioactive lipids in PD gained through preclinical and clinical studies is expected to improve the understanding of disease pathogenesis and provide novel therapeutic avenues.
Blockchain‐based IoT architecture to secure healthcare system using identity‐based encryption
Authors: Sharma Pratima , Moparthi Nageswara Rao , Namasudra Suyel , Shanmuganathan Vimal , Hsu Ching‐Hsien 
Published: December 2021

AbstractNowadays, blockchain and Internet of Things (IoT) are two emerging areas of the Information Technology (IT) sector. These two emerging areas are used in various fields, such as supply chain, logistics and automotive industry. Due to the low processing power and storage space of IoT devices, users' medical information is usually saved in a centralized third party like a clinical repository or a cloud computing environment. Thus, in many cases, users lose control of their medical information, which can result in security disclosure and a single‐point impediment. So, an advanced solution is required to improve the data sharing process, while restricting it in terms of security. Blockchain technology with IoT can significantly affect the healthcare industry by improving its efficiency, security and transparency, as well as can provide more business opportunities. The efficient sharing of Electronic Health Record (EHR) can improve the treatment process, diagnosis accuracy, security and privacy. This article proposes a blockchain‐based IoT architecture to provide enhanced security of healthcare data by using Identity‐Based Encryption (IBE) algorithm. Here, the smart contract defines all the basic operations of the healthcare system, which can be beneficial to all stakeholders. Many experiments are executed to evaluate the efficiency of the proposed scheme. The results show that the proposed scheme is better than the existing renowned schemes.
Soil enzymes as indicators of soil function: A step toward greater realism in microbial ecological modeling
Authors: Wang Gangsheng , Gao Qun , Yang Yunfeng , Hobbie Sarah E , Reich Peter B , Zhou Jizhong 
Published: December 2021

AbstractSoil carbon (C) and nitrogen (N) cycles and their complex responses to environmental changes have received increasing attention. However, large uncertainties in model predictions remain, partially due to the lack of explicit representation and parameterization of microbial processes. One great challenge is to effectively integrate rich microbial functional traits into ecosystem modeling for better predictions. Here, using soil enzymes as indicators of soil function, we developed a competitive dynamic enzyme allocation scheme and detailed enzyme‐mediated soil inorganic N processes in the Microbial‐ENzyme Decomposition (MEND) model. We conducted a rigorous calibration and validation of MEND with diverse soil C‐N fluxes, microbial C:N ratios, and functional gene abundances from a 12‐year CO2 × N grassland experiment (BioCON) in Minnesota, USA. In addition to accurately simulating soil CO2 fluxes and multiple N variables, the model correctly predicted microbial C:N ratios and their negative response to enriched N supply. Model validation further showed that, compared to the changes in simulated enzyme concentrations and decomposition rates, the changes in simulated activities of eight C‐N‐associated enzymes were better explained by the measured gene abundances in responses to elevated atmospheric CO2 concentration. Our results demonstrated that using enzymes as indicators of soil function and validating model predictions with functional gene abundances in ecosystem modeling can provide a basis for testing hypotheses about microbially mediated biogeochemical processes in response to environmental changes. Further development and applications of the modeling framework presented here will enable microbial ecologists to address ecosystem‐level questions beyond empirical observations, toward more predictive understanding, an ultimate goal of microbial ecology.
Bioenergy sorghum’s deep roots: A key to sustainable biomass production on annual cropland
Authors: Lamb Austin , Weers Brock , McKinley Brian , Rooney William , Morgan Cristine , Marshall‐Colon Amy , Mullet John 
Published: December 2021

AbstractBioenergy sorghum has high biomass yield potential, drought resilience, good nitrogen use efficiency, and a root system that contributes to the accumulation of soil organic carbon. In this study, field grown bioenergy sorghum root systems were analyzed during the growing season to characterize their depth, biomass, morphology, anatomy, and gene expression profiles. Bioenergy sorghum roots grew continuously during a 155‐day growing season producing ~175 nodal roots, accumulating ~7 Mg of dry biomass per hectare, and reaching >2 m deep in the soil profile. Nodal roots within 20 cm of the stem were 1–5 mm in diameter, whereas roots deeper in soil profiles were enriched in lateral roots with small diameters (~30–500 µm) enabling growth through soil macropores. In older field‐grown plants, roots with intact endodermal, vascular and inner root tissues were surrounded by degraded or aerenchyma‐filled epidermal and cortical cell layers. Transcriptome analysis of nodal, surface, and deep roots identified >2,500 differentially expressed genes involved in root growth, transport, adaptation, defense, and AMF–root interaction. Deep roots (180–240 cm) differentially expressed genes that regulate lateral root growth. Surface roots (0–20 cm) located mid‐row differentially expressed genes involved in nitrate transport, whereas ammonium transport genes were expressed in surface and deep roots and genes involved in phosphate transport were expressed in nodal, surface, and deep roots. Overall, bioenergy sorghum's long growing season enables root systems to grow deeper and accumulate more biomass than annual grain crops such as maize, attributes that could help restore annual cropland soil organic carbon levels and improve soil productivity. Deep roots active in nutrient transport are positioned to take‐up fertilizer leached deep into soil profiles mitigating potential nutrient run‐off. Bioenergy sorghum's large and deep root system is a key to sustainable production of biofuels, biopower, and bioproducts on annual cropland.
Conceptualisations of positive mental health and wellbeing among children and adolescents in low‐ and middle‐income countries: A systematic review and narrative synthesis
Authors: Renwick Laoise , Pedley Rebecca , Johnson Isobel , Bell Vicky , Lovell Karina , Bee Penny , Brooks Helen 
Published: December 2021

AbstractBackgroundMental illnesses are the leading causes of global disease burden. The impact is heightened in low‐ and middle‐income countries (LMICs) due to embryonic care systems and extant barriers to healthcare access. Understanding children and adolescents' conceptualisations of mental health wellbeing in these settings is important to optimize health prevention and promotion initiatives.ObjectiveTo systematically review and synthesize children and adolescents' conceptualisations and views of mental health and wellbeing in LMICs.DesignTen databases were systematically searched from inception to July 2020 and findings from included studies were synthesized.ResultsTwenty papers met eligibility criteria comprising qualitative, quantitative and mixed methods studies. Children and adolescents identified aspects of mental health and wellbeing, including positive affect and outlook and having sufficient personal resources to face daily challenges. Identified factors recognized the importance of activating both kin and lay networks in supporting and maintaining wellbeing. Conceptualisations of mental health and wellbeing were varied and influenced by culture, developmental stage and gender.Discussion and ConclusionsIrrespective of environmental and sociocultural influences on concepts of wellbeing and mental health, children and adolescents in LMICs can conceptualise these constructs and identify how they pursue positive mental health and wellbeing important for developing age and culture‐appropriate community mental health strategies. Our review highlights the need to extend inquiry to wider developmental stages and both across and within specific populations in LMICs.Patient and Public InvolvementInitial results were presented at stakeholder workshops, which included children, adolescents, parents and health professionals held in Indonesia in January 2019 to allow the opportunity for feedback.