bluuebunny/crossref_metadata_2025_split huggingface dataset:
Taguchi Grey Relational Optimization of the Multi-mechanical Characteristics of Kaolin Reinforced Hydroxyapatite: Effect of Fabrication Parameters
Authors: Abifarin Johnson Kehinde , Olubiyi David Olubiyi , Dauda Emmanuel Toi , Oyedeji Elijah Oyewusi 
Published: December 2021

Comparative study of kaolin reinforced hydroxyapatite (KHAp) and pure HAp using different production parameters has been done through traditional experimentation. However, the quantitative effect, optimization of kaolin reinforcement and fabrication parameters have not been investigated. Hence, this study examines the effect of kaolin reinforcement, compaction pressure and sintering temperature on the experimental mechanical properties of HAp. Taguchi design assisted by grey relational analysis was employed with L36 (2**2 3**1) orthogonal array. The Minitab 16 software was used to analyze the Taguchi design. The result showed a disparity in kaolin reinforcement as the optimum condition for individual mechanical properties, but the grey relational analysis showed better mechanical properties with kaolin reinforcement, 500 Pa compaction pressure and 1100 oC sintering temperature. The obtained result further revealed kaolin reinforcement as a strong and promising reinforcing material for high strength clinical application, having a contribution of 93.16% on compressive strength of HAp. Therefore, future studies can be conducted in the use of different wt% of kaolin on the multi-response mechanical characteristics of HAp.
Effect of Transformational Leadership Style and Work Commitment on Employee Performance at the Regional Secretariat of Murung Raya Regency, Central Kalimantan Province
Authors: Yohana  , Humaidi  
Published: December 2021

This study aims to determine the Effect of Transformational Leadership Style and Work Commitment on Employee Performance at the Regional Secretariat of Murung Raya Regency, Central Kalimantan Province. The technique used in this study is SmartPLS Analysis using the help of the SmartPLS package computer program with a significance level of 5 percent by using questionnaires as primary data. The population in this study were employees of the Regional Secretariat of Murung Raya Regency as many as 192 people with a sample of the same number as many as 192 respondents who used saturated sampling techniques, that is, the entire population was sampled.
The results of this study indicate that partially transformational leadership style and work commitment have a significant effect on employee performance, this means that an increase in transformational leadership style and work commitment will improve employee performance at the Murung Raya Regency Regional Secretariat. To maintain employee performance at the Murung Raya Regency Secretariat, it can be done by using transformational leadership styles and managing work commitments. It is important to take actions that can improve work commitment and employee performance
RANCANG BANGUN ALAT PENETAS TELUR AYAM OTOMATIS DENGAN PENGIRIMAN DATA VIA SMS GATEWAY BERBASIS ARDUINO NANO
Authors: Asali Stenly , Sollu Tan Suryani 
Published: December 2021

In rural areas, free-range chickens are raised naturally, that is, the eggs are incubated by their parents directly so that the breeding of chickens is not optimal, because the native hens are only able to incubate a few eggs. Therefore an automatic chicken egg incubator is needed.
Egg incubators that use automatic controllers in order to facilitate the hatching process, get maximum hatching results as expected and be able to find hatching information remotely by sending information via sms gateway. The hatching temperature is 37-380C and turning the eggs every 8 hours, starting from the eggs being put in the incubator until the eggs hatch. The data from the sensors will be processed in the diarduino and sent to the hatchery owner via SIM800L V.2 when the sound sensor detects the sound of the hatched egg. The information about the eggs that have been hatched comes from the sound sensor, even though the farmer is not in the hatchery.
Experiments were carried out using 20 chicken eggs as a sample. The results of the successful hatching test were 4 chickens with a 20% success percentage, due to a power cut during the hatching process.
El narrador del Carmen Paschale en el relato de la muerte y resurrección de Jesús.
Authors: Hernández Mayor Mª Dolores 
Published: December 2021

In the Paschale Carmen the storyteller’s irruptions are frequent from the beginning of the book first, as shown in the metric prologue and in abundant loci of programmatic sense. The interventions of the narrator’s voice take on a different tone in the last book, dedicated to the Passion and Resurrection of Jesus. It’s shows that the program of the entire poem reaches its culmination in the faithful defense that the devout narrator makes of Christian doctrine against the lack of faith of the Jewish people. In this work we analyze some moments of the fifth book of Paschale Carmen in which this dogmatic intention of the narrator is evident, apart from his role as narrator of the miracles.
En el Carmen Paschale las irrupciones del narrador son frecuentes desde el inicio del libro primero, como se demuestra en el prólogo métrico y en abundantes loci de sentido programático. Las intervenciones de la voz del narrador cobran un tono diferente en el último libro, dedicado a la Pasión y Resurrección de Jesús. En él se comprueba que el programa de todo el poema alcanza su culminación en la fiel defensa que el devoto narrador realiza de la doctrina cristiana frente a la falta de fe del pueblo judío. En este trabajo se analizan algunos momentos del libro quinto del Carmen Paschale en los que queda patente esa intención dogmática del narrador, al margen de su papel como relator de milagros.
Evaluating the Construct of Damage in Systemic Lupus Erythematosus
Authors: Johnson Sindhu R. , Gladman Dafna D. , Brunner Hermine I. , Isenberg David , Clarke Ann E. , Barber Megan R. W. , Arnaud Laurent , Fortin Paul R. , Mosca Marta , Voskuyl Alexandre E. , Manzi Susan , Aranow Cynthia , Askanase Anca , Alarcón Graciela S. , Bae Sang‐Cheol , Costedoat‐Chalumeau Nathalie , English Jessica A. , Pons‐Estel Guillermo J. , Pons‐Estel Bernardo A. , Gilman Rebecca , Ginzler Ellen M. , Hanly John G. , Jacobsen Soren , Kalunian Kenneth , Kamen Diane L. , Lambalgen Chynace , Legge Alexandra , Lim S. Sam , Mak Anselm , Morand Eric F. , Peschken Christine A. , Petri Michelle , Rahman Anisur , Ramsey‐Goldman Rosalind , Reynolds John A. , Romero‐Diaz Juanita , Ruiz‐Irastorza Guillermo , Sanchez‐Guerrero Jorge , Svenungsson Elisabet , Touma Zahi , Urowitz Murray , Vinet Evelyne , van Vollenhoven Ronald F. , Waldhauser Heather , Wallace Daniel J. , Zoma Asad , Bruce Ian N. 
Published: December 2021

ObjectiveThe Systemic Lupus International Collaborating Clinics (SLICC), American College of Rheumatology (ACR), and the Lupus Foundation of America are developing a revised systemic lupus erythematosus (SLE) damage index (the SLICC/ACR Damage Index [SDI]). Shifts in the concept of damage in SLE have occurred with new insights into disease manifestations, diagnostics, and therapy. We evaluated contemporary constructs in SLE damage to inform development of the revised SDI.MethodsWe conducted a 3‐part qualitative study of international SLE experts. Facilitated small groups evaluated the construct underlying the concept of damage in SLE. A consensus meeting using nominal group technique was conducted to achieve agreement on aspects of the conceptual framework and scope of the revised damage index. The framework was finally reviewed and agreed upon by the entire group.ResultsFifty participants from 13 countries were included. The 8 thematic clusters underlying the construct of SLE damage were purpose, items, weighting, reversibility, impact, time frame, attribution, and perspective. The revised SDI will be a discriminative index to measure morbidity in SLE, independent of activity or impact on the patient, and should be related to mortality. The SDI is primarily intended for research purposes and should take a life‐course approach. Damage can occur before a diagnosis of SLE but should be attributable to SLE. Damage to an organ is irreversible, but the functional consequences on that organ may improve over time through physiological adaptation or treatment.ConclusionWe identified shifts in the paradigm of SLE damage and developed a unifying conceptual framework. These data form the groundwork for the next phases of SDI development.
Nanovesicle‐Mediated Targeted Delivery of Immune Checkpoint Blockades to Potentiate Therapeutic Efficacy and Prevent Side Effects
Authors: Jung Mungyo , Kang Mikyung , Kim Byung‐Seok , Hong Jihye , Kim Cheesue , Koh Choong‐Hyun , Choi Garam , Chung Yeonseok , Kim Byung‐Soo 
Published: December 2021

AbstractDespite the clinically proven efficacies of immune checkpoint blockades, including anti‐cytotoxic T lymphocyte‐associated protein 4 antibody (αCTLA‐4), the low response rate and immune‐related adverse events (irAEs) in cancer patients represent major drawbacks of the therapy. These drawbacks of αCTLA‐4 therapy are mainly due to the suboptimal activation of tumor‐specific cytotoxic T lymphocytes (CTLs) and the systemic nonspecific activation of T cells. To overcome such drawbacks, αCTLA‐4 is delivered by dendritic cell‐derived nanovesicles presenting tumor antigens (DCNV‐TAs) that exclusively interact with tumor‐specific T cells, leading to selective activation of tumor‐specific CTLs. Compared to conventional αCTLA‐4 therapy, treatment with αCTLA‐4‐conjugated DCNV‐TAs significantly inhibits tumor growth and reduces irAEs in syngeneic tumor‐bearing mice. This study demonstrates that the spatiotemporal presentation of both αCTLA‐4 and tumor antigens enables selective activation of tumor‐specific T cells and potentiates the antitumor efficacy of αCTLA‐4 without inducing systemic irAEs.
2D Materials for All‐Solid‐State Lithium Batteries
Authors: Ma Qianyi , Zheng Yun , Luo Dan , Or Tyler , Liu Yizhou , Yang Leixin , Dou Haozhen , Liang Jiequan , Nie Yihang , Wang Xin , Yu Aiping , Chen Zhongwei 
Published: December 2021

AbstractAlthough one of the most mature battery technologies, lithium‐ion batteries still have many aspects that have not reached the desired requirements, such as energy density, current density, safety, environmental compatibility, and price. To solve these problems, all‐solid‐state lithium batteries (ASSLB) based on lithium metal anodes with high energy density and safety have been proposed and become a research hotpot in recent years. Due to the advanced electrochemical properties of 2D materials (2DM), they have been applied to mitigate some of the current problems of ASSLBs, such as high interface impedance and low electrolyte ionic conductivity. In this work, the background and fabrication method of 2DMs are reviewed initially. The improvement strategies of 2DMs are categorized based on their application in the three main components of ASSLBs: The anode, cathode, and electrolyte. Finally, to elucidate the mechanisms of 2DMs in ASSLBs, the role of in situ characterization, synchrotron X‐ray techniques, and other advanced characterization are discussed.
Highly Transparent and Self‐Healable Solar Thermal Anti‐/Deicing Surfaces: When Ultrathin MXene Multilayers Marry a Solid Slippery Self‐Cleaning Coating
Authors: Niu Wenwen , Chen George Y. , Xu Haolan , Liu Xiaokong , Sun Junqi 
Published: December 2021

AbstractSolar anti‐/deicing can solve icing problems by converting sunlight into heat. One of the biggest problems, which has long been plaguing the design of solar anti‐/deicing surfaces, is that photothermal materials are always lightproof and appear black, because of the mutual exclusiveness between generating heat and retaining transparency. Herein, a highly transparent and scalable solar anti‐/deicing surface is reported, which enables the coated glass to exhibit high transparency (>77% transmittance at 550 nm) and meanwhile causes a >30 °C surface temperature increase relative to the ambient environment under 1.0 sun illumination. Such a transparent anti‐/deicing surface can be fabricated onto a large class of substrates (e.g., glass, ceramics, metals, plastics), by applying a solid omniphobic slippery coating onto layer‐by‐layer‐assembled ultrathin MXene multilayers. Hence, the surface possesses a self‐cleaning ability to shed waterborne and oil‐based liquids thanks to residue‐free slipping motion. Passive anti‐icing and active deicing capabilities are, respectively, obtained on the solar thermal surface, which effectively prevents water from freezing and simultaneously melts pre‐formed ice and thick frost. The self‐cleaning effect enables residue‐free removal of unfrozen water and interfacially melted ice/frost to boost the anti‐/deicing efficiency. Importantly, the surface is capable of self‐healing under illumination to repair physical damage and chemical degradation.
Copper Sulfate‐Catalyzed Asymmetric 1,4‐Addition of Amido‐Functionalized Allylboronates to Maleimides in Water
Authors: Sengoku Tetsuya , Kajihara Takuto , Inaba Mari , Yoda Hidemi 
Published: December 2021

AbstractA new application of amido‐functionalized allylboronates to asymmetric 1,4‐addition in water has been developed. Extremely high enantioselective 1,4‐addition was achieved by employing N‐mesityl maleimide as a substrate under CuSO4/bis(oxazoline) catalysis, affording the adduct with >99% ee.
Lifetime Multiplexing with Lanthanide Complexes for Luminescence In Situ Hybridisation
Authors: Jia Jianguo , Ren Peng , Hu Honghua , Sayyadi Nima , Parvin Farhana , Zheng Xianlin , Shi Bingyang , Piper James A. , Song Bo , Vickery Karen , Lu Yiqing 
Published: December 2021

AbstractLong‐lived luminescence probes with engineered lifetimes offer great potential for multiplexed biodetection and imaging at high sensitivity and contrast. The overwhelming majority of lifetime‐multiplexing probes are based on luminescent nanoparticles; however, these typically suffer practical limitations compared to molecular probes when applied to biological systems. By surveying commercially available ligands for lanthanide coordination, we identify three europium complexes with distinguishable lifetime from 100 μs to 1 ms. Spectroscopic analysis reveals this to be due to intrinsic radiative lifetime and non‐radiative relaxation. These europium complexes are developed as in situ hybridisation probes for luminescence lifetime imaging of bacterial biofilms. Utilising time‐resolved detection we achieve sensitive and robust detection and identification of the target bacteria species, thus demonstrating the practicality of lanthanide‐based molecular probes for lifetime multiplexing.
Aerobic epoxidation of olefins by carboxylate ligand‐based cobalt (II) compound: synthesis, X‐ray crystallography, and catalytic exploration
Authors: Patra Birendra Nath , Ghosh Pameli , Sepay Nayim , Gayen Saikat , Koner Subratanath , Brandao Paula , Lin Zhi , Debnath Rakesh , Pratihar Jahar Lal , Maity Tanmay , Mal Dasarath 
Published: December 2021

AbstractA new quinoline carboxylate‐based cobalt (II) metal compound, [Co (HL1)2(H2O)4] (1) (H2L1 = 2‐hydroxyquinoline‐4‐carboxylic acid) has been hydrothermally synthesized, and fully characterized by single‐crystal X‐ray diffraction, powder X‐ray diffraction, Fourier‐transform infrared (FT‐IR), elemental and thermo‐gravimetric analysis. Compound 1 shows high thermal stability up to ~300°C. Single‐crystal X‐ray diffraction study of 1 exhibited monomeric structure experiences further stabilized in solid state through different non‐covalent interaction, for example, H‐bonding and π···π stacking interaction and extended to 3D supramolecular H‐bonded network. Compound 1 efficiently catalyzes epoxidation reactions of olefins under homogeneous conditions using molecular oxygen as an oxidizer. Another reported quinoline carboxylate‐based nickel (II) monomer [Ni(L2)2(H2O)2] (2) (HL2 = thiazole‐4‐carboxylic acid) has been synthesized and characterized to compare it with compound 1 towards aerobic epoxidation reactions, where 1 comes as superior.
Hatchery release programme modified the genetic diversity and population structure of wild Chinese sucker (Myxocyprinus asiaticus) in the upper Yangtze River
Authors: Wu Jiayun , Chen Yongbo , Li Chong , Song Zhaobin 
Published: December 2021

AbstractThe Chinese sucker (Myxocyprinus asiaticus) is an endangered and threatened fish species in China. To augment wild populations, millions of captive‐bred Chinese sucker have been released into the upper Yangtze River in recent years, with little evaluation of the genetic impact.The genetic diversity of 112 wildM. asiaticusfrom different reaches of the Yangtze River was examined, and the population structure among them and three artificially bred populations was determined using 12 microsatellite markers. Genetic data from the wildM. asiaticuspopulations before the hatchery release programme were synthesized and compared to detect fine‐scale variation in genetic structure together with spatiotemporal changes in the wild population.The results showed that the genetic diversity of wildM. asiaticuswas relatively high (observed heterozygosity = 0.604–0.609, polymorphic information content = 0.442–0.496), even though a moderate decrease in total diversity was detected when compared with previous studies.M. asiaticusfrom the Wanzhou reaches, which showed low genetic variation before the stocking programmes, displayed the highest level of genetic diversity (observed heterozygosity = 0.609, polymorphic information content = 0.496) in this study. Insignificant differences in genetic structure among wild populations, with low genetic differentiation (Fst = 0.035–0.083), as well as close genetic relationships between wild and hatchery populations were observed.Current genetic diversity and population structure of wildM. asiaticuswere strikingly different from those before the hatchery release programme, which indicated that stocking activities have altered the genetic character of the populations in the upper Yangtze River. The conservation ofM. asiaticusrequires legal protection for the fish and its habitat. Genetic monitoring of the wild populations and accurate evaluation of genetic divergence is imperative. In addition, the results of this study should be used to provide scientific guidance for an effective hatchery release programme forM. asiaticus.
Structural information of nanosized iron oxide clusters serendipitously poses the solution of long‐standing problems on nanomaterials: Intra/inter surfactant and core–surfactant interaction
Authors: Choi Jihyun , Yoon Sungho 
Published: December 2021

AbstractDetailed information on the surface structure of surfactant‐protected metal oxide nanoparticles (NPs) is limited due to the difficulties in preparing samples suitable for single‐crystal x‐ray diffraction analysis. Herein, we report the synthesis and x‐ray structural analysis of 4‐biphenylcarboxylic acid‐protected nanosized iron oxide, comprising 11 Fe(III) ions, 6 O atoms, 6 (OH) ions, and 15 biphenylcarboxylates. The carboxylate bridges the adjacent Fe(III) ions in the core and the core form a slightly twisted pentacapped trigonal prism. In addition, widespread intercalation between the phenyl groups on the surface of the nanoparticles is observed.
Development and application of an analytical approach to assess an antibody's potential for disulfide reduction
Authors: Yang Yanhong , Bastani Niutish , Lagler Sara K. , Harris Doug , Nagy Attila , Chen Peifeng , Patel Aakash , Li Yile , Gowetski Daniel B. , Lei Q. Paula 
Published: December 2021

AbstractMonoclonal antibody (mAb) interchain disulfide bond reduction has been observed in a recent large‐scale clinical manufacturing operation. A massive reduction/precipitation at post‐clarification steps has occurred. This note presents the development of a novel analytical approach to identify the “potential reduction”—a unique approach to predict the propensity of a monomeric‐profiled mAb to be reduced in the post‐harvest stage, such as harvest clarification and/or purification steps. The core of this new approach includes comparing the non‐reducing capillary electrophoresis profiles of pre‐ and post‐vacuum treated mAb in harvest cell culture fluid (HCCF). Using this approach, the potential reductions of two in‐house mAbs in the unclarified and clarified cell culture harvest were assessed.
Effect of online counselling on emotional outcomes during the COVID‐19 pandemic: An innovative group intervention for university students using the Brain Wave Modulation Technique
Authors: Celia Giovanna , Cavicchiolo Elisa , Girelli Laura , Limone Pierpaolo , Cozzolino Mauro 
Published: December 2021

AbstractYoung people's mental health problems are a matter of concern during the COVID‐19 pandemic. Counselling services for university students by means of telemental support can help them to deal with psychological issues that they may be facing due to the pandemic. The present study investigated the effects of four once‐weekly online counselling sessions based on a mind‐body technique (the Brain Wave Modulation Technique; BWM‐T) on enhancing positive affect and on reducing negative affect and anxiety in a sample of 54 university students (96.3% females; Mage = 21.31 years, SD = 2.09). An experimental design was conducted: the participants were randomly assigned to the intervention group, which received 15 min of a guided online BWM‐T session, or to the control group, which watched a 15‐min video on how to sustain their psychological well‐being. The results of a two‐factor mixed‐design analysis of variance (ANOVA) showed that the participants in the intervention group reported a significant increase in positive affect and a decrease in negative affect over time compared to those in the control group. They also reported a slight decrease in state anxiety compared to the control group, although this was just short of statistical significance. The information provided by this study, regarding emotional outcomes among university students after four brief online counselling sessions, suggests that such interventions could be an effective and sustainable way to reinforce young people's mental health during the COVID‐19 pandemic, as well as later in their university careers and adult lives.