bluuebunny/crossref_metadata_2025_split huggingface dataset:
Production planning decision of a dairy under supply disruption and demand uncertainty
Authors: Jena Dayanidhi , Ray Pritee 
Published: October 2021

Purpose
The purpose of this paper is to develop a model for the production planning decision of a dairy plant in a multi-product setting under supply disruption risk and demand uncertainty while determining the optimal product-mix and material planning requirement.

Design/methodology/approach
A mixed-integer nonlinear programming model is proposed to determine the optimal product-mix that maximizes the expected profit of a dairy. The data are collected through visits to the dairy site, conducting brainstorming sessions with the plant manager and marketing head at the corporate office. Disruption data are collected from the India Meteorological Department, Odisha.

Findings
From the analysis, it is recommended that the dairy should not produce curd during the planning period. Moreover, turnover from toned, double toned and baby food is maximum than that of the curd and these products are produced in the planning period. The expected profit increases from its present value when an optimal product-mix is followed. Sensitivity analysis is performed to analyze the effect of demand uncertainty, supply disruption and production quota. The expected profit decreases as the supply failure probability increases.

Research limitations/implications
The model is implemented in a dairy plant under Orissa State Cooperative Milk Producers Federation, Odisha, India. The proposed methodology has not been validated, theoretically. The concerned dairy is based on the Indian context, but the authors believe that the study is highly relevant to other dairies as well.

Practical implications
This study provides a methodology for dairy plant managers to plan production effectively under supply disruption risk with demand uncertainty. It also suggests material requirement planning at different factories of the dairy plant.

Originality/value
This paper develops a mathematical model for the production planning decision of a dairy plant that determines the optimal product-mix, which maximizes the expected profit of a dairy under disruption risk and demand uncertainty (in the Indian context).
Managing positional innovation in small food enterprises. The bakery industry
Authors: Linzalone Roberto , Lerro Antonio 
Published: October 2021

PurposeThe concept of positional innovation – as one of the four innovation types of the Francis and Bessant’s “4P’s” model – is an effective product innovation strategy for producers of mature and credence goods as food products are. Despite the acknowledgement as one of the major industries worldwide, positional innovations about the food products are underexplored in the managerial literature. To fill this gap, this paper first develops a theoretical analysis of the concepts. Then, by adopting a case-study research methodology, it discloses the way a bakery small enterprise manages positional innovation. Theoretical and practical implications are finally introduced and discussed.Design/methodology/approachAfter a literature review about the role and the characteristics of the positional innovation, the paper presents a case study of definition and implementation of managerial actions and initiatives driven by positional innovation. The aim is not to report on an inductive study, but to use this example as a picture to clarify theory and show how the various conceptual issues may be operatively applied and provide more contextual insights.FindingsIt emerges how a small food enterprise manages positional innovation to survive and compete in the national and international markets; the positional innovation sources are tapped into culture, social responsibility, tradition and other territorial assets of tangible and intangible nature, effectively combined to innovate the product perception and/or the utility in a use context.Originality/value“Non-technological”, simple products, like food, are underexplored and rarely seen as relevant context to investigate along the strategic and innovation management literature. Nonetheless, positional innovation is a perspective that values and credits the innovation efforts of small food products, revealing interesting managerial concepts and inspiring entrepreneurs and managers for activating and sustaining new strategies of innovation for their businesses.
Vitamin D status and dietary intake in young university students in the UK
Authors: Dong Honglin , Asmolovaite Viktorija , Marseal Nareen , Mearbon Maryam 
Published: October 2021

PurposeVitamin D deficiency is prevalent worldwide. This paper aims to investigate the vitamin D status and dietary intake in young university students.Design/methodology/approachForty-one healthy students aged 18–29 years from Coventry University UK were recruited during January-February 2019, including white Caucasians (n = 18), African-Caribbeans (n = 14) and Asians (n = 9). Plasma 25(OH)D concentrations were measured and dietary vitamin D intake was determined. Chi-square and simple linear regression were used to analyse the data.FindingsThe plasma 25(OH)D concentrations were (36.0 ± 22.2) nmol/L in all subjects, (46.5 ± 25.3) nmol/L in white Caucasians, (22.6 ± 7.4) nmol/L in African-Caribbeans and (37.4 ± 21.7 nmol/L) in Asians. The majority (85.7%) of African-Caribbeans were vitamin D deficient compared with 22.2% of white Caucasians and 33.3% of Asians (p= 0.001). Overweight/obese subjects showed a significant higher proportion of vitamin D deficiency (65%) than normal weight subjects (28.6%) (p= 0.04). The average dietary vitamin D intake in all subjects was (4.6 ± 3.9) µg/day. Only 12.1% of the subjects met the recommended dietary vitamin D intake of 10 µg/day. Dietary vitamin D intake (p= 0.04) and ethnicity (p= 0.01) were significant predictors of 25(OH)D levels and accounted for 13% and 18.5% of 25(OH)D variance, respectively.Research limitations/implicationsThis small-scale study showed an alarmingly high prevalence of vitamin D deficiency among subjects from African-Caribbean origin during wintertime. Education programs and campaigns are urgently needed to fight the vitamin D deficiency in this population.Originality/valueThe targeted population were in a critical period of transition from adolescence toward adulthood involving in changes in behaviours and nutrition.
Modern nanobiotechnologies for efficient detection and remediation of mercury
Authors: Gaur Mulayam Singh , Yadav Rajni , Kushwah Mamta , Berlina Anna Nikolaevna 
Published: October 2021

Purpose
This information will be useful in the selection of materials and technology for the detection and removal of mercury ions at a low cost and with high sensitivity and selectivity. The purpose of this study is to provide the useful information for selection of materials and technology to detect and remove the mercury ions from water with high sensitivity and selectivity. The purpose of this study is to provide the useful information for selection of materials and technology to detect and remove the mercury ions from water with high sensitivity and selectivity.

Design/methodology/approach
Different nano- and bio-materials allowed for the development of a variety of biosensors – colorimetric, chemiluminescent, electrochemical, whole-cell and aptasensors – are described. The materials used for their development also make it possible to use them in removing heavy metals, which are toxic contaminants, from environmental water samples.

Findings
This review focuses on different technologies, tools and materials for mercury (heavy metals) detection and remediation to environmental samples.

Originality/value
This review gives up-to-date and systemic information on modern nanotechnology methods for heavy metal detection. Different recognition molecules and nanomaterials have been discussed for remediation to water samples. The present review may provide valuable information to researchers regarding novel mercury ions detection sensors and encourage them for further research/development.
Adult‐onset immunodeficiency due to anti‐interferon‐gamma autoantibody‐associated Sweet syndrome: A distinctive entity
Authors: Kiratikanon Salin , Phinyo Phichayut , Rujiwetpongstorn Rujira , Patumanond Jayanton , Tungphaisal Veeraphol , Mahanupab Pongsak , Chaiwarith Romanee , Tovanabutra Napatra , Chiewchanvit Siri , Chuamanochan Mati 
Published: October 2021

AbstractSweet syndrome (SS) has been increasingly reported in patients with adult‐onset immunodeficiency (AOID) due to anti‐interferon‐γ autoantibody who also have concomitant opportunistic infections, especially disseminated non‐tuberculous mycobacterial infection (dNTMI). A retrospective study retrieving data from 2011 through 2020 was conducted. We compared clinical characteristics of SS with and without AOID and generated the prediction model and examined the interaction between AOID and dNTMI in the occurrence of SS. Lymphadenopathy, pustular lesions, and leukocytosis are the significant predictors for AOID‐associated SS. Adjusted risk differences were 0.58 (95% confidence interval [CI], 0.33–0.83), 0.21 (95% CI, 0.02–0.39), and 0.24 (95% CI, 0.01–0.47), respectively. Based on the analysis of aggregated cross‐sectional data, both the overall and the direct effect of AOID increased the prevalence of SS. The indirect effect of AOID on the occurrence of SS might also be mediated through dNTMI or other common opportunistic infections. In addition, there was a trend of positive additive interaction between AOID and dNTMI. Although the test of additive interaction did not reveal statistically significant results, a deviation from additivity of isolated effects might suggest potential causal interaction between AOID and dNTMI. The distinctive clinical syndrome comprising lymphadenopathy, pustular lesions, and leukocytosis in patients with SS should raise the awareness of clinicians to the potential of underlying AOID.
Resource heterogeneity but not inbreeding affects growth and grouping behaviour in socially foraging juvenile cichlid fish
Authors: Schons Rieke F. , Vitt Simon , Thünken Timo 
Published: October 2021

Abstract

Spatial food distribution determines resource profitability, defensibility and encounter rate of foragers. Clumped food distribution can promote aggressiveness and resource monopolisation, in turn increasing within‐group variation in food intake and growth. However, the effects of food distribution may depend on foraging strategies. Little is known about the impact of spatial food heterogeneity on growth and grouping behaviour in social foragers in the absence of monopolisation.

Social foraging is present in many fishes, particularly at early juvenile life stages when fish are especially sensitive to environmental variation. Here, a heterogeneous food distribution may impair foraging success and growth and juveniles may increase sociability to attain social information about food resources.

We examined the impact of the spatial distribution of food as well as inbreeding on growth and social behaviour in juveniles of the cichlid fish Pelvicachromis pulcher. Inbred individuals often show poorer performance than outbred individuals (inbreeding depression), but inbreeding effects can be environment dependent. In the experiment, inbred and outbred fish were reared in a split‐clutch design either under homogeneously distributed or spatially clumped food conditions for 8 weeks starting 1 week after juveniles could actively feed. We documented growth and performed a shoaling assay and a sociality test (choice between a large vs. a small shoal) after 6 weeks.

Spatial food distribution did not affect within‐group body length variation, but individuals reared under clumped food conditions were smaller. Shoals of the different feeding conditions differed in social behaviour. Shoals of the clumped treatment group showed higher variation in inter‐individual distances compared to shoals of the homogeneous treatment group. Furthermore, focal fish of the clumped treatment adjusted their association preference to the position of the groups' largest individual. We did not find significant inbreeding or environment‐dependent inbreeding effects regarding growth or social behaviour.

Our study suggests that a clumped food distribution can impede localisation of food resources and thus growth in juvenile social foragers. Accordingly, in heterogeneous environments, the use of social information may be highly relevant to increase individuals' foraging success potentially explaining orientation on successful foragers, that is, large individuals. Inter‐individual variation in juvenile’s social behaviour may precede variation in food monopolisation capability and in growth emerging at later life stages.

A free Plain Language Summary can be found within the Supporting Information of this article.
Predictive impacts of chronic kidney disease and cardiac sympathetic nervous activity on lethal arrhythmic events in chronic heart failure
Authors: Amami Kazuaki , Yamada Shinya , Yoshihisa Akiomi , Kaneshiro Takashi , Hijioka Naoko , Nodera Minoru , Nehashi Takeshi , Takeishi Yasuchika 
Published: October 2021

AbstractBackgroundThe clinical implications of chronic kidney disease (CKD) and cardiac sympathetic nervous activity (CSNA) regarding lethal arrhythmic events have not yet been fully elucidated in patients with chronic heart failure (CHF). We hypothesized that the combination of CKD and abnormal CSNA, assessed by 123I‐metaiodobenzylguanidine (123I‐MIBG) scintigraphy, may provide useful prognostic information for lethal arrhythmic events.MethodsWe studied 165 consecutive hospitalized CHF patients without dialysis. Cardiac 123I‐MIBG scintigraphy was performed in a clinically stable condition, and abnormal CSNA was defined as a late heart‐to‐mediastinum ratio of <1.6. CKD was defined as an estimated glomerular filtration rate of <60 ml/min/1.73 m2. We then investigated the incidence of lethal arrhythmic events (sustained ventricular tachyarrhythmia, appropriate implantable cardioverter‐defibrillator therapy, or sudden cardiac death).ResultsDuring a median follow‐up of 5.3 years, lethal arrhythmic events were observed in 40 patients (24.2%). The patients were divided into four groups according to the presence of CKD and CSNA abnormality: non‐CKD/normal CSNA (n = 52), CKD/normal CSNA (n = 39), non‐CKD/abnormal CSNA (n = 33), and CKD/abnormal CSNA (n = 41). Kaplan–Meier analysis showed that CKD/abnormal CSNA had the highest event rate (log‐rank p = .004). Additionally, the Cox proportional hazard analysis revealed that CKD/abnormal CSNA was a predictor for lethal arrhythmic events compared with non‐CKD/normal CSNA (hazard ratio, 5.368, p = .001). However, the other two groups did not show significant differences compared with the non‐CKD/normal CSNA group.ConclusionsThe combination of CKD and abnormal CSNA, assessed by 123I‐MIBG scintigraphy, had a high predictive value for lethal arrhythmic events in patients with CHF.
Drain fluid amylase and lipase as a predictive factor of postoperative pancreatic fistula
Authors: Koek Sharnice , Wiegele Sophie , Ballal Mohammed 
Published: October 2021

AbstractBackgroundEarly detection of a postoperative pancreatic fistula (POPF) may improve outcomes after pancreaticoduodenectomy (PD). The aim was to assess the role of postoperative drain fluid amylase (DFA) and lipase (DFL) measurements as a predictive indicator in the development of POPF.MethodsThis retrospective cohort study included all PD procedures performed between 2009 and 2017 at Fremantle and Fiona Stanley Hospital in Western Australia. The DFA and DFL measurements on postoperative day (POD) three and five were correlated with the development of POPF.ResultsA total of 169 patients were included in this study with a mean age of 64 ± 11.3 years. Of these, 17 (10.1%) developed a clinically significant POPF. In patients who had both a DFA and DFL measured on both POD 3 and 5, DFA and DFL was significantly higher in patients who developed POPF than those who did not (P < 0.001). In a receiver operating characteristic curve analysis, the most accurate test was POD 3 DFL measurement with an AUC 0.85 (CI 0.75–0.95, P < 0.001). A negative predictive value of 97.4% was observed. DFA and DFL were concordant in 89.2% of cases on POD 3 and 90.6% of cases on POD 5.ConclusionIn this study, DFL measured on POD 3 as a single measurement appears to carry the most benefit in prediction of clinically significant POPF. Reduction to a measurement on this day may lead to a reduction in cost, earlier drain removal and earlier identification of high‐risk patients.
A comparison of outcomes and survival between Victoria and Denmark in lung cancer surgery: opportunities for international benchmarking
Authors: Stenger Michael , Jakobsen Erik , Wright Gavin , Zalcberg John , Stirling Robert G. 
Published: October 2021

AbstractBackgroundsVictoria (Australia) and Denmark have comparable population sizes and high‐quality healthcare systems. Lung cancer surgery, however, is performed in more than 20 Victorian hospitals compared to four in Denmark. Such differences in centralization may influence outcomes. We engaged clinical quality registries to enable international benchmarking by exploring patterns of lung cancer surgery including mortality and survival.MethodsAll patients undergoing lung cancer surgery between 2015 and 2018 registered in the Victorian Lung Cancer Registry and the Danish Lung Cancer Registry were included. Analyses on stage concordance, 30 and 90‐day mortality, and overall survival were restricted to a selected subgroup with NSCLC and no neo‐adjuvant therapy or metastatic disease and only one operation.ResultsWe included 1554 Victorian and 4319 Danish patients. The resection rate was 26.3% in Victoria and 28% in Denmark, but a higher proportion of Victorian patients underwent wedge resection (19.1% versus 8.8%). Stage concordance was 59.6% and 54.9% in Victoria and Denmark, respectively. The 30‐ and 90‐day mortality was 1.3% and 2.6% in Victoria, compared to 1.4% and 2.8% in Denmark with no difference in overall survival (p = 0.28) or risk‐adjusted survival (HR: 1.10 (95% CI: 0.89–1.37); p = 0.38).ConclusionHigh‐quality surgical lung cancer care was confirmed by similar high resection and low mortality rates including no overall survival difference. The drivers and consequences of stage discordance and differences in patterns of resection deserve further exploration. This study provides a model for international benchmarking using clinical quality registries, although caution remains in the interpretation given disparities in data completeness.
Long‐term bisphosphonate therapy and atypical femoral fracture: Can you have too much of a good thing?
Authors: Walker Lauren E. , Cooper Cyrus 
Published: October 2021

AbstractThe long‐term, continuous use of bisphosphonates (beyond 5 years) is not wholly without risk. Atypical femoral fracture is an uncommon but potentially very serious adverse event associated with the long‐term use of bisphosphonates. Here we consider the complexities of long‐term bisphosphonate prescribing, particularly in those that are low risk of osteoporotic fracture, wherein the duration of therapy should be reviewed regularly with individualised risk assessment to ensure the duration of treatment is appropriate.
Retracted: Fuzzy based rendezvous points selection for mobile data gathering in wireless sensor network
Authors: Satish Patil Sunita , Senthil Kumaran Thangamuthu 
Published: October 2021

AbstractIn this article, fuzzy based rendezvous points selection (FRPS) technique for mobile data gathering in wireless sensor networks is proposed. At beginning, the importance of detected data is categorized into perilous and non‐perilous based on the perseverance and time limit of data. Then two Sencars are set up: one for gathering perilous data by visiting straight to the corresponding sensors, the other one for gathering non‐perilous data from other sensors. The rendezvous points (RPs) for visiting the Sencars are determined by using fuzzy decision model based on the input parameters energy level, buffer occupancy level, and current load. Based on the output of this model, each sensor is assigned a combined utility value. Then the sensors with high utility values are selected as RPs and the details are broadcast to the respective Sencars.
VO2peak prior to transplant differentiates survival post kidney transplant
Authors: Chakkera Harini A. , Kaplan Bruce , Budhiraja Pooja , Behmen Senaida , Fitz‐Patrick Dennis , Butterfield Richard J. 
Published: October 2021

AbstractThe OPTN/UNOS utilizes the calculated estimated posttransplant survival (EPTS) score as the measure of post‐kidney transplant survival to guide allocation of deceased donor kidney transplantation. This score does not include any metric of functional capacity. Peak oxygen uptake (VO2peak), is an established predictor of survival among both the general and diseased populations. We assessed the association and discriminative capacity of VO2peak and that of EPTS score and all‐cause mortality post‐kidney transplant. Additionally, we assessed the “mortality risk” lower VO2peak conferred on those patients with low EPTS score. Among a cohort of 293 transplant recipients with at least 3‐years post‐transplant follow‐up, the median VO2peak was 15.0 ml/Kg/min. Lower pre‐transplant VO2peak and higher EPTS score conferred higher risk of post‐transplant mortality. Among the cohort of “low‐risk” patients (patients with EPTS score < 50) those with lower VO2peak had significantly higher risk of mortality (log rank p = 0.045). In fact, the mortality risk among those with low‐EPTS (< 50) and low VO2peak < 12 ml/Kg/min was equivalent to those with high EPTS (> 80) score. We concluded functional capacity as defined by VO2peak is an important reflection of post‐transplant survival. VO2peak is able to identify those with low EPTS who have similar survival to that of high EPTS phenotype.
Outcomes of adjunctive therapies post hedgehog inhibitors in the management of locally advanced basal cell carcinoma: A systematic review and pooled analysis
Authors: Patel Arsh , Kim Jane S. , Liss Jason , Howard Lauren , Jung Sin‐Ho , Kheterpal Meenal 
Published: October 2021

AbstractManagement of patients with locally advanced basal cell carcinoma (laBCC) with traditional strategies has yielded suboptimal outcomes. Targeted treatments including hedgehog inhibitor therapy (HHIT) present limitations when utilized as monotherapy. Herein, we report evidence‐based outcomes from available literature on multimodality treatments adjuvant to HHIT in laBCC management. Utilizing a systematic search strategy in PubMed, we identified studies published from inception to April 15, 2020, screened for definitive inclusion/exclusion criteria, and performed individual study quality assessment and pooled analysis to assess impact of adjunctive treatment‐based responses post‐HHIT on clinical response and recurrence outcomes. Twenty‐nine studies (n = 103) were included. Primary findings include a complete response (CR) rate of 90.5%, the median follow‐up of 12 months post‐HHIT completion. The recurrence rate was 10.8% with 12‐month median time to recurrence. Mohs micrographic surgery (MMS) had 100% CR post‐HHIT, while no difference was observed between surgery and radiation therapy (RT). MMS and surgery had comparable 2‐year recurrence free rates (RFR) at 87% and 86% respectively, while RT had the lower 2‐year RFR at 67%. Male gender portended a more advanced stage at diagnosis and worse outcomes. In a subset analysis, periorbital laBCCs with orbital involvement had a CR rate of 81.8% versus 100% in those without orbital involvement, with similar rates of recurrence. Limited available quantitative data and possible publication bias were limitations. Pooled analysis of observational data supports use of adjunctive therapies post‐HHIT to improve treatment response in patients with laBCC. Longer‐term follow‐up is needed to study recurrence rates after combination therapy.