bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zinc Borate Composites Based on Recycled PVC Wastes Via Comparing Melt Mixing and Casting Procedures Under the Effect of Electron Beam Irradiation
Authors: Fathy E.S. , Elnaggar Mona , Raslan Heba A. , Hassan Medhat M. 
Published: November 2021

Abstract
With the remarkable increase in whether heat in many countries, many scientific researchers aim to deal with this problem by developing polymeric materials that have good mechanical and thermal properties and are resistant to heat and fire. Polyvinyl chloride is used for decoration and construction materials. This article goals to the usage of waste polyvinyl chloride (WPVC) as based polymer composites containing zinc borate particles (ZnB) prepared via two different techniques equipped by melt mixing WPVC/ZnB (M) and casting WPVC/ZnB (C). The fabricated composites by the two methods were irradiated in an electron beam accelerator (EB) at 30 kGy. A comparative study of the mechanical, and thermal properties, as well as the rate of heat burning for the two methods, has been performed. Furthermore, activation energy calculation, FTIR, and XRD have been considered. The observed improvement in the mechanical, thermal, and flammability behavior of the samples was reached by the incorporation of ZnB particles and EB irradiation. Also, composites films prepared by melt mixing reveal superior properties than those equipped by casting for the most investigated factors.
Melatonin differences between day and night milk in primiparous holstein friesian and jersey dairy cattle
Authors: Boztepe Saim , KESKIN İsmail , SEMACAN Ahmet , AKYUREK Fikret , AYTEKIN İbrahim , SAHIN Ozcan 
Published: November 2021

Abstract
This study was conducted to determine the levels of melatonin in the day and night milk of Holstein and Jersey cows. In the study, samples of daytime milk produced from 27 head of Holstein and 27 head of Jersey cows in the first lactation, which were raised in a private dairy cattle enterprise in the Kaşınhanı neighborhood of Meram district of Konya city Turkey, and night milk samples taken from the same cows that were blackened for one (1) week were used. Melatonin levels in milk samples taken from day and night milk were determined separately for Holstein and Jersey cows with the help of Bovine Melatonin (MLT) Elisa Kit. In the study, it was determined that the ratio of melatonin in day and night milk in Holstein cows was 2.912 pg/ml and 11.314 pg/ml, respectively, and the ratio of melatonin in Jersey cows was 2.924 pg/ml and 6.954 pg/ml in the same order. The difference between the melatonin levels of the day and night milk of Holstein and Jersey cows was found to be statistically significant (p<0.01). At the end of the study, it can be stated that night milk can be used for medical purposes and a new production source may arise for producers since there is a significant difference in melatonin between day and night milk.
Effect of N-cadherin on Chondrogenic Differentiation of Bone Marrow Derived Mesenchymal Stem Cells through Wnt Signaling Pathway
Authors: Feng Qu , Xuezhen Shen , Haipeng Li , Jingbin Zhou , Bangtuo Yuan , Chunbao Li , Wei Qi , Liu Yujie , Mingzhu Zhang 
Published: November 2021

Abstract
Objective: To compare and analyze the effect of N-cadherin on chondrogenic differentiation of bone marrow derived mesenchymal stem cells (BMSCs) and to explore the related mechanism, so as to provide a novel theoretical basis for the clinical work of articular cartilage injury regeneration and repair.Methods: The experimental animals were clean grade SD rats (aged 5-6 weeks, weighing 180-250g). Alcian blue staining was carried out to observe the induced chondrogenesis following N-cadherin inhibition. The specific role of N-cadherin in Wnt signaling pathway and chondrogenic differentiation of BMSCs was detected by Western blot; while the effect of N-cadherin on the molecular level changes of β-catenin in cytoplasm was evaluated by fluorescence quantitative real-time PCR (qRT-PCR). In addition, immunocoprecipitation (IP) was used for the verification of the interaction between N-cadherin and β-catenin.Results: Under the light microscope, 90% of the BMSCs at the third generation, 90% of the cells were fused. Alcian blue staining showed that the green staining area in BMP2 induction group was large and dense, while that in N-cadherin inhibition group and blank control group was small and sparse. Western blot revealed that N-cadherin and SOX9 were significantly developed in BMP2 induction group, but Wnt3a was not significantly developed. While in N-cadherin inhibition group, the development of Wnt3a was obvious, yet without evident development of N-cadherin and SOX9. qRT-PCR indicated that the relative mRNA expression of Wnt3a was significantly increased in N-cadherin inhibition group (P<0.05). However, no obvious difference was observed in the mRNA expression of β-catenin between BMP2 induction group and N-cadherin inhibition group (P>0.05). Western blot indicated that in BMP2 induction group, there existed the development of β-catenin, significant development of phos-GSK-3β and total GSK-3β, but no obvious development of Wnt3a. In N-cadherin inhibition group, there were significantly enhanced development of Wnt3a and β-catenin than that before, blurred development of phos-GSK-3β than that before, and also obvious development of total GSK-3β with little change from before. N-cadherin promoted the expression of β-catenin mostly in the cell membrane, but only a few in the cytoplasm and nucleus. Additionally, verification by IP showed that N-cadherin and β-catenin were developed on N-cadherin and β-catenin bands, suggesting an interaction between N-cadherin and β-catenin. Conclusion: To sum up, N-cadherin can inhibit Wnt signaling pathway by inhibiting hub factors of this pathway. Wnt signaling pathway can inhibit chondrogenic differentiation of BMSCs. Collectively, N-cadherin can ultimately promotes chondrogenic differentiation of BMSCs by inhibiting Wnt signaling pathway.
Risk Factors for Multiple Implant-Related Complications (MIRC) with Growing-Rod for Early-Onset Scoliosis
Authors: Jiang Haijun , Hai Junrui Jonathan , Hai Yong , Yin Peng , Su Qingjun , Zhou Lijin , Zhu Shiqi , Pan Aixing , Wang Yunsheng , Liu Ziyang 
Published: November 2021

Abstract
Study design: A retrospective single center study.Objective：To identify risk factors for multiple implant-related complications with growing-rod for early-onset scoliosis.Background: High incidence of implant-related complications in the treatment of early-onset scoliosis with traditional growing rod. The risk factors for multiple implant-related complications (MIRC) have not been adequately studied.Methods: Data of 59 early-onset scoliosis patients who had been underwent growing rod surgery at Beijing Chao-yang Hospital from September 2007 to December 2017 were reviewed. All patients had complete clinical and radiographic data. Patients were divided into groups with or without MIRC. The univariate and multivariate logistic regression analysis were performed to identify the risk factors associated MIRC.Results: The average age of insertion was 8.9 years and mean follow-up was 51.91 months. 234 implantation or expansion surgeries were performed and the average operation interval was 11.4 months. A total of 60 implant-related complications occurred. Ultimately, MIRC developed in 20 (33.9%) of 59 patients. Number of surgery procedure > 3 times , follow-up time ³50 months , preoperative thoracic kyphosis > 50°, postoperative thoracic kyphosis >50°, postoperative lumbar lordosis >50°, postoperative sagittal vertical axial >40mm are potential risk factors for MIRC (P<0.1). Multivariate logistic regression analysis showed that Number of surgery procedure > 3 times, postoperative thoracic kyphosis >50°, postoperative lumbar lordosis >50°are independent risk factors for MIFRC (P<0.05), Among them, patients with postoperative thoracic kyphosis >50°had an 18.647 times higher risk of MIFRC than postoperative thoracic kyphosis angle <50°.Conclusions: Traditional growing rod in the setting of EOS has excellent clinical and radiographic outcomes but a high multiple implant-related complications. Number of surgery procedure > 3 times, postoperative thoracic kyphosis >50°, postoperative lumbar lordosis >50° are independent risk factors for MIRC.
Liquid Biopsy Using Ascites and Pleural Effusion Supernatant for Genomic Profiling in Gastrointestinal and Lung Cancers
Authors: Wu Hui-Ta , Ji Hao-Nan , Yang Wen-Hui , Zhang Min , Guo Yi-Fang , Li Bang-Kai , Wang Jia-Yin , Chen Rong-Rong , Chen Yuan , Wang Xin 
Published: November 2021

Abstract
Background: Precision medicine highlights the importance of incorporating molecular genetic testing into standard clinical care. Next-generation sequencing (NGS) can detect cancer-specific gene mutations, and molecular targeted drugs can be designed to be effective for one or more specific gene mutations. For patients with special site metastasis, it is particularly important to use appropriate samples for genetic profiling test.Methods: Tissues, plasma, ascites (ASC) supernatants, pleural effusion (PE) samples from gastrointestinal (GI) patients with peritoneal metastasis and lung cancer patients with pleural metastasis were collected for comprehensive genomic profiling. The sample were performed on next-generation sequencing (NGS) using 59 or 1021 cancer-relevant genes panel. Results: The study enrolled 156 tissues, 188 plasma, 45 ascites supernatants, and 1 pleural effusion in 304 GI group and 446 pleural effusion supernatants, 122 tissues, 389 plasma, 45 pleural effusion sediments in 407 lung cancer group. The MSAF were significantly higher in ASC and PE supernatant than plasma ctDNA (50.18% ± 32.03% vs 12.31% ± 19.90%, p < 0.0001 and 33.74% ± 28.34% vs 6.28% ± 12.17%, p < 0.0001, respectively). ASC supernatant had a higher actionable mutation rate than plasma. ASC supernatant accounts for more actionable alterations than plasma ctDNA in 26 paired samples. PE supernatant had higher total actionable mutation rate than plasma (80.3% vs 48.4%, p < 0.05). PE supernatant had a higher frequency of uncommon variations than plasma no matter had distant organ metastasis. Conclusion: ASC and PE supernatants could be better alternatives when tumor tissues are not available in the real world, especially in patients who have only peritoneal or pleural metastases.
Neoadjuvant Chemotherapy For Stage II–III Breast Cancer: A Single-Center Experience
Authors: Zaher Haidi Abd El , Fathy Hamada , Abozeid Mohamed , Faisal Mohammed 
Published: November 2021

Abstract
Introduction: We conducted this study to reflect a single-center experience with the use of neoadjuvant systemic chemotherapy for the management of women with operable breast cancer.Methods: We conducted a retrospective chart review on all women presenting with operable, stage II-III, breast cancer and were scheduled for neoadjuvant systemic chemotherapy at Suez Canal University Hospital. The primary outcome of this study was to estimate the proportion of patients with operable breast cancer who become eligible for breast conservative surgery (CBS) after neoadjuvant systemic chemotherapy.Results: A total of 147 patients were included. Before the initiation of chemotherapy, only 66 (44.9%) patients were indicated for breast conservative surgery (CBS). A total of 40 (50.6%) new patients, out of the 81 patients who were ineligible before chemotherapy, became eligible for breast conservative surgery after neoadjuvant chemotherapy (95% CI 39.3 – 61.9%). On the other hand, nine (13.6%) patients became ineligible for breast conservative surgery after neoadjuvant chemotherapy. Out of the 98 eligible patients for breast conservative surgery after chemotherapy, 72 (73.5%) patients underwent the surgery and the remaining 26 patients chose total modified radical mastectomy (MRM). A total of 55 (76.4%) patients achieved pathological complete response pCR. One woman (0.1%) experienced relapse at the 3rd year of follow-up and three women (2%) experienced relapse at the 5th year of follow-up. The difference between patients who underwent breast conservative surgery and total mastectomy was not statistically significant (p =0.22 and 0.07, respectively).Conclusion: Neoadjuvant chemotherapy can play a crucial role in increasing the rate of eligibility for breast conservative surgery among women with operable, stage II-III, breast cancer.
Experimental investigation of scouring around a single spur under clear water conditions
Authors: Özyaman Cansu , Yerdelen Cahit , Eris Ebru , Daneshfaraz Rasoul 
Published: November 2021

Abstract
This study presents the effect of different parameters on the scouring process around spur dikes. Our research group's stated objective was to evaluate the effects of sediment gradation, flow depth, spur angle and spur length on the scouring process. Since most existing studies generally employed uniform sediment, in this study uniform and non-uniform sediment were selected. Experiments were made in a rectangular open channel in uniform flow conditions. Results showed that the effect of the spur dike length and the orientation angle on sediment scour varies with the type of sediment used. Scour volumes were 40% greater in uniform sediments than in non-uniform sediments. Measured scour depth was maximum at spurs perpendicular to the flow, whereas the scour volume was maximum at spurs directed upstream. The scour depth increased with an increase in the spur length; however, the effect of spur length on scouring varied at a contraction rate of 0.29 for uniform sediments and 0.36 for non-uniform sediments. A multiple regression analysis was also performed, and four equations were suggested to predict the scour depth and scour volume. Comparisons were made with the literature equations applicable for clear-water scouring to check the suggested equation. Because of the wide range of contraction ratios considered in this study, the equations which considered the contraction effect yielded better estimates.
Physicochemical, Interaction & Topological Descriptors vs. hMAO-A Inhibition of Aplysinopsin Analogs: A Boulevard to the Discovery of Semi-synthetic Antidepression Agents
Authors: Singla Rajeev K. , Ashraf Ghulam Md. , Ganash Magdah , G. Varadaraj Bhat , Shen Bairong 
Published: November 2021

Background:
Depression, a neurological disorder, is globally the 4th leading cause of chronic disabilities
in human beings.

Objective:
This study aimed to model a 2D-QSAR equation that can facilitate the researchers to design better aplysinopsin
analogs with potent hMAO-A inhibition.

Methods:
Aplysinopsin analogs dataset were subjected to ADME assessment for drug-likeness suitability using
StarDrop software before modeled equation. 2D-QSAR equations were generated using VLife MDS 4.6. Dataset was
segregated into training and test set using different methodologies, followed by variable selection. Model development
was done using principal component regression, partial least square regression, and multiple regression.

Results:
The dataset has successfully qualified the drug-likeness criteria in ADME simulation, with more than 90%
of molecules cleared the ideal conditions, including intrinsic solubility, hydrophobicity, CYP3A4 2C9pKi, hERG
pIC50, etc. 112 models were developed using multiparametric consideration of methodologies. The best six models
were discussed with their extent of significance and prediction capabilities. ALP97 was emerged out as the most
significant model out of all, with ~83% of the variance in the training set, the internal predictive ability of ~74%,
while having the external predictive capability of ~79%.

Conclusion:
ADME assessment suggested that aplysinopsin analogs are worth investigating. Interaction among the
descriptors in the way of summation or multiplication products are quite influential and yield significant 2D-QSAR
models with good prediction efficiency. This model can be used to design a more potent hMAO-A inhibitor with an
aplysinopsin scaffold, which can then contribute to the treatment of depression and other neurological disorders.
Mediating effect of ethical climate on the relationship of personality types and employees mindfulness
Authors: Ramos Rowena Imelda A. , Mata Ryan Ray M. , Nacar Rosalie C. 
Published: November 2021

Globalization and technological advancement bring changes to the organization as well as to the behaviors of the employees. As a result, this descriptive-correlational study examined the effect of perceived ethical climate on individual differences – personality types and psychological state – mindfulness among employees. Purposive sampling was utilized to include 203 participants from different higher institutions who agreed to answer a questionnaire in google forms that were distributed through their emails. Results revealed respondents’ personality types have high levels of agreeableness, conscientiousness, and open-mindedness with moderate level of extraversion and low level of negative emotionality. Individual and organizational mindfulness of the participants were considerably very high. The participants perceived their organizations to have high level of consideration on rules, standard operating procedures and law and professional codes with moderate regard personal morality. More importantly, results of structural equation modeling established the claim that ethical climate increases the significant association of personality types to employees’ mindfulness. With the evident association of personality types and mindfulness, trainings should be provided to enhance employees’ personality and deal with possible differences. The significant mediating effect of ethical climate encourage organizational leaders to establish a work environment that uplifts employee’s morale to increase mindfulness.
Wpływ pracy w czasie pandemii covid-19 na stres personelu pielęgniarskiego
Authors: Grzelak Lech , Szwarc Piotr 
Published: November 2021

Wstęp. Obciążenie stresem należy do poważnych zagrożeń zawodowych w pielęgniarstwie. Pandemia COVID-19 dodatkowo postawiła wiele nowych wyzwań przed personelem medycznym, co może powodować większe obciążenia psychiczne.
Cel. Celem badań była ocena wpływu pandemii COVID-19, na stres personelu pielęgniarskiego, niepracującego w bezpośrednim kontakcie z zakażonymi.
Materiały i metody. Badaniem objęto grupę 65 osób z personelu pielęgniarskiego, pracującego w siedmiu oddziałach szpitalnych. Wiek badanych mieścił się w zakresie 20–65 lat. W badaniach wykorzystano ankietę opracowaną na użytek badania oraz jedno standardowe narzędzia pomiaru, tj. Skalę Odczuwanego Stresu (PSS-10).
Wyniki. Wybuch pandemii spowodował zmianę w odczuwaniu stresu u 98,5% badanych. 89,2% osób zauważyło u siebie nasilone objawy stresu. Stres potęgowały przede wszystkim zmiany na poziomie organizacji pracy oraz lęk przed zakażeniem i przeniesieniem wirusa z pracy na rodzinę. U 6,2% badanych często pojawiały się myśli o rezygnacji lub zmianie pracy. Po roku pracy w pandemii, stres utrzymywał się na poziomie średnim i niskim.
Wnioski. Poziom odczuwania stresu, mierzonego rok po wybuchu pandemii, nie wskazuje na obciążenie nadmiernym stresem, a na fazę adaptacji w sytuacji kryzysowej. Skutki pracy w długotrwałym stresie mogą być widoczne dopiero w przyszłości. Wskazane jest dalsze monitorowanie stresu i objęcie personelu pielęgniarskiego wsparciem psychologicznym.
Ocena stopnia deficytu w zakresie podstawowych czynności dnia codziennego
Authors: Maciejewska Maria Magdalena 
Published: November 2021

Wstęp. Starzenie się organizmu jest dynamicznym i nieodwracalnym procesem naszego organizmu. Możliwość sprawowania samoopieki czyli wykonanie we własnym zakresie czynności takich jak poruszanie się, odżywianie, kontrolowanie potrzeb fizjologicznych i utrzymanie higieny osobistej należy utożsamić z niezależnością.
Cel. Celem pracy jest ocena stopnia deficytu w zakresie podstawowych czynności dnia codziennego wśród osób objętych opieką długoterminową stacjonarną.
Materiał i metody. W mojej pracy badawczej narzędziem jest analiza dokumentacji medycznej pacjentów w zakresie skali Barthel.
Wyniki. Analiza uzyskanych badań własnych pozwoliła na sformułowanie następujących wyników:
Płeć ma istotny wpływ na możliwość poruszania się badanych osób. Wiek ma znaczny wpływ na możliwość mycia, kąpieli całego ciała. Istnieje istotna zależność pomiędzy miejscem pobytu osób starszych a możliwością korzystania z toalety.
Wnioski. Płeć ma wpływ na możliwość poruszania się badanych osób. Wiek ma wpływ na możliwość mycia, kąpieli całego ciała. Istnieje zależność pomiędzy miejscem pobytu osób starszych a możliwością korzystania z toalety.
Technology-Based Interventions for Cancer Caregivers: Concept Analysis
Authors: Su Zhaohui , Li Xiaoshan , McDonnell Dean , Fernandez Andrea A , Flores Bertha E , Wang Jing 
Published: November 2021

Background
Cancer is a taxing chronic disease that demands substantial care, most of which is shouldered by informal caregivers. As a result, cancer caregivers often have to manage considerable challenges that could result in severe physical and psychological health consequences. Technology-based interventions have the potential to address many, if not all, of the obstacles caregivers encounter while caring for patients with cancer. However, although the application of technology-based interventions is on the rise, the term is seldom defined in research or practice. Considering that the lack of conceptual clarity of the term could compromise the effectiveness of technology-based interventions for cancer caregivers, timely research is needed to bridge this gap.

Objective
This study aims to clarify the meaning of technology-based interventions in the context of cancer caregiving and provide a definition that can be used by cancer caregivers, patients, clinicians, and researchers to facilitate evidence-based research and practice.

Methods
The 8-step concept analysis method by Walker and Avant was used to analyze the concept of technology-based interventions in the context of cancer caregiving. PubMed, PsycINFO, CINAHL, and Scopus were searched for studies that examined technology-based interventions for cancer caregivers.

Results
The defining attributes of technology-based interventions were recognized as being accessible, affordable, convenient, and user-friendly. On the basis of insights gained on the defining attributes, antecedents to, and consequences of technology-based interventions through the concept analysis process, technology-based interventions were defined as the use of technology to design, develop, and deliver health promotion contents and strategies aimed at inducing or improving positive physical or psychological health outcomes in cancer caregivers.

Conclusions
This study clarified the meaning of technology-based interventions in the context of cancer caregiving and provided a clear definition that can be used by caregivers, patients, clinicians, and researchers to facilitate evidence-based oncology practice. A clear conceptualization of technology-based interventions lays foundations for better intervention design and research outcomes, which in turn have the potential to help health care professionals address the needs and preferences of cancer caregivers more cost-effectively.