bluuebunny/crossref_metadata_2025_split huggingface dataset:
Good to excellent long-term survival of a single-design condylar constrained knee arthroplasty for primary and revision surgery
Authors: Theil C. , Schwarze J. , Gosheger G. , Poggenpohl L. , Ackmann T. , Moellenbeck B. , Schmidt-Braekling T. , Ahrens H. 
Published: June 2021

Abstract
Purpose
The purpose of the study was to determine the long-term survivorship, functional outcomes of a single-design condylar constrained (CCK) TKA in primary and revision cases as well as to assess specific risk factors for failure. It was hypothesized that primary CCK TKA had a better survival than revision knees.

Methods
One hundred and forty three patients who underwent revision TKA (n = 119) or complex primary TKA (n = 24) using a single-design condylar constrained knee system (Genesis CCK, Smith & Nephew) performed at a single institution between 1999 and 2008 were retrospectively included. The median follow-up amounted to 11.8 years (IQR 10.3–14.4). Implant survivorship was analyzed using Kaplan–Meier survival estimates and multivariate Cox regression analysis to identify risk factors for failure. Function was determined using the Oxford Knee Score (OKS).

Results
The implant survival was 86.4% after five, 85.5% after ten and 79.8% at 15 years. A reduced implant survivorship was found in males (HR 5.16, p = 0.001), smokers (HR 6.53, p = 0.004) and in obese patients (HR 2.26, p = 0.095). Patients who underwent primary TKA had a higher revision-free implant survivorship compared to revision TKA at 15 years (100% vs. 76%, p = 0.036). The main cause for re-revision was infection in 10% of all revision TKA performed with the CCK design included, while no case was revised for instability.
The median OKS was 39 (IQR 35–44) in 102 patients available for long-term functional outcome.

Conclusion
CCK implants are associated with excellent long-term survival when used in primary TKA; however, survival was worse when used during revision TKA. Males, smokers, obese patients and are at higher risk for revision. While instability and aseptic loosening were rare, infection remains a major concern.

Level of evidence
Level IV, retrospective observational study.
Differentiation of peach cultivars by image analysis based on the skin, flesh, stone and seed textures
Authors: Ropelewska Ewa , Rutkowski Krzysztof P. 
Published: June 2021

AbstractThe peaches belonging to different cultivars can be characterized by differentiation in properties. The aim of this study was to evaluate the usefulness of individual parts of fruit (skin, flesh, stone and seed) for cultivar discrimination of peaches based on textures determined using image analysis. Discriminant analysis was performed using the classifiers of Bayes net, logistic, SMO, multi-class classifier and random forest based on a set of combined textures selected from all color channels R, G, B, L, a, b, X, Y, Z and for textures selected separately for RGB, Lab and XYZ color spaces. In the case of sets of textures selected from all color channels (R, G, B, L, a, b, X, Y, Z), the accuracy of 100% was observed for flesh, stones and seeds for selected classifiers. The sets of textures selected from RGB color space produced the correctness equal to 100% in the case of flesh and seeds of peaches. In the case of Lab and XYZ color spaces, slightly lower accuracies than for RGB color space were obtained and the accuracy reaching 100% was noted only for the discrimination of seeds of peaches. The research proved the usefulness of selected texture parameters of fruit flesh, stones and seeds for successful discrimination of peach cultivars with an accuracy of 100%. The distinguishing between cultivars may be important for breeders, consumers and the peach industry for ensuring adequate processing conditions and equipment parameters. The cultivar identification of fruit by human may be characterized by large errors. The molecular or chemical methods may require special equipment or be time-consuming. The image analysis may ensure objective, rapid and relatively inexpensive procedure and high accuracy for peach cultivar discrimination.
Responder analysis for neuropathic impairment and quality-of-life assessment in patients with hereditary transthyretin amyloidosis with polyneuropathy in the NEURO-TTR study
Authors: Yarlas Aaron , Lovley Andrew , Brown Duncan , Kosinski Mark , Vera-Llonch Montserrat 
Published: June 2021

Abstract
Objective
Hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) is a rare disease characterized by rapid neuropathic progression. In pivotal studies of gene-silencing treatments, the modified Neuropathy Impairment Score + 7 tests (mNIS + 7) and Norfolk-Quality of Life (QOL)-Diabetic Neuropathy (DN) questionnaire assessed treatment impact on neuropathic progression. Establishing responder definition (RD) thresholds for these measures would enable evaluation of clinically meaningful treatment benefit.

Methods
mNIS + 7 and Norfolk-QOL-DN were administered at baseline and week 65 to 165 adults with ATTRv-PN receiving inotersen (n = 106) or placebo (n = 59) in the NEURO-TTR study. Anchor-based approaches for estimating RD thresholds were used for Norfolk QOL-DN, while distribution-based approaches were used for both measures. Responders were patients with a score change < RD, indicating improvement or stabilization (i.e., no clinically meaningful progression). Odds ratios (ORs) and Fisher’s exact tests compared proportions of responders by treatment.

Results
The mean RD estimates were 12.2 points and 8.8 points for mNIS + 7 and Norfolk QOL-DN, respectively. The proportions of patients whose change in score indicated improvement or stabilization were statistically significantly larger for inotersen than placebo for all estimated RD thresholds for mNIS + 7 (64–86% responders for inotersen vs. 27–46% for placebo, ORs = 3.8–7.2, ps < 0.001) and Norfolk QOL-DN (66–81% vs. 35–56%, ORs = 2.4–3.6, ps < 0.05).

Discussion
Establishing RD thresholds for these instruments enables evaluation of clinically relevant and individual-level treatment benefit on neuropathic progression. Across RDs estimated using multiple methods, a higher proportion of patients receiving inotersen than placebo showed improved or stabilized neuropathic progression at week 65.

Trial registration
ClinicalTrials.gov Identifier: NCT01737398; Date of registration: November 29, 2012.
Reduction of carbonyl compounds via hydrosilylation catalyzed by well-defined PNP-Mn(I) hydride complexes
Authors: Weber Stefan , Iebed Dina , Glatz Mathias , Kirchner Karl 
Published: June 2021

AbstractReduction reactions of unsaturated compounds are fundamental transformations in synthetic chemistry. In this context, the reduction of polarized double bonds such as carbonyl or C=C motifs can be achieved by hydrogenation reactions. We describe here a highly chemoselective Mn(I)-based PNP pincer catalyst for the hydrosilylation of aldehydes and ketones employing polymethylhydrosiloxane (PMHS) as inexpensive hydrogen donor.
Graphic abstract
Modellierung der Strömungsdynamik in einem revitalisierten Küstenmoorgebiet an der Ostsee
Authors: Schreiber Lisa , Munz Matthias , Salzmann Thomas , Oswald Sascha E. 
Published: June 2021

ZusammenfassungKüstennahe Niedermoore wurden durch den Menschen verändert, bspw. durch das Anlegen von Entwässerungsgräben, dem Bau von Küstenschutzdeichen oder aktuell einer Renaturierung. Außerdem ist es wichtig die komplexe Interaktion mit der See zu verstehen, um Aussagen über die zukünftige Entwicklung treffen zu können. In der vorliegenden Studie wurde die ober- und unterirdische Strömung in einem Feuchtgebiet an der mecklenburgischen Ostseeküste nahe Warnemünde (Deutschland) untersucht, um dessen wechselseitigen Austausch mit der Ostsee zu quantifizieren und zu analysieren, wie sich ein Sturmhochwasserereignis auf den Salzeintrag ins Gebiet auswirkt. Hierfür wurde ein dreidimensionales instationäres Grundwassermodell erstellt, mit einem eindimensionalen Modell des Grabensystems gekoppelt und mit Messungen im Gebiet kalibriert und verglichen. Die Ergebnisse zeigen, dass neben der oberirdischen Entwässerung auch der Grundwasserabstrom in Richtung Ostsee eine wesentliche Komponente der Wasserbilanz darstellt. Das Verhalten entlang der Küste wird deutlich durch die Dynamik der Ostseewasserstände geprägt, wobei ein Grundwasserabstrom mit einem Zustrom von Ostseewasser bei hohen Küstenwasserständen innerhalb täglicher bis wöchentlicher Zeitskalen wechselt.
Time-dynamic evaluations under non-monotone information generated by marked point processes
Authors: Christiansen Marcus C. 
Published: June 2021

AbstractThe information dynamics in finance and insurance applications is usually modelled by a filtration. This paper looks at situations where information restrictions apply so that the information dynamics may become non-monotone. A fundamental tool for calculating and managing risks in finance and insurance are martingale representations. We present a general theory that extends classical martingale representations to non-monotone information generated by marked point processes. The central idea is to focus only on those properties that martingales and compensators show on infinitesimally short intervals. While classical martingale representations describe innovations only, our representations have an additional symmetric counterpart that quantifies the effect of information loss. We exemplify the results with examples from life insurance and credit risk.
Thermal modeling of a Swiss urban aquifer and implications for geothermal heat pump systems
Authors: Perego Rodolfo , Pera Sebastian , Boaga Jacopo , Bulgheroni Monica , Dalla Santa Giorgia , Galgaro Antonio 
Published: June 2021

AbstractThe progressive electrification of the building conditioning sector in recent years has greatly contributed to reducing greenhouse gas emissions by using renewable energy sources, particularly shallow geothermal energy. This energy can be exploited through open and closed shallow geothermal systems (SGS), and their performances greatly depend on the ground/groundwater temperature, which can be affected by both natural and anthropogenic phenomena. The present study proposes an approach to characterize aquifers affected by high SGS exploitation (not simulated in this work). Characterization of the potential hydro/thermogeological natural state is necessary to understand the regional flow and heat transport, and to identify local thermal anomalies. Passive microseismic and groundwater monitoring were used to assess the shape and thermal status of the aquifer; numerical modeling in both steady-state and transient conditions allowed understanding of the flow and heat transport patterns. Two significant thermal anomalies were detected in a fluvio-glacial aquifer in southern Switzerland, one created by river water exfiltration and one of anthropogenic nature. A favorable time lag of 110 days between river and groundwater temperature and an urban hot plume produced by underground structures were observed. These thermal anomalies greatly affect the local thermal status of the aquifer and consequently the design and efficiency of current and future SGS. Results show that the correct characterization of the natural thermo-hydrogeological status of an aquifer is a fundamental basis for determining the impact of boundary conditions and to provide initial conditions required to perform reliable local thermal sustainability assessments, especially where high SGS exploitation occurs.
Envy effects on conflict dynamics in supervised work groups
Authors: Dal Forno Arianna , Merlone Ugo 
Published: June 2021

AbstractAt the end of the last century, chaos theory principles have helped organizational theorists to analyze several aspects of organizations and to account for their dynamic evolution. However, most of contributions remained relegated as qualitative discussions of organizational phenomena. In this paper, starting from effort allocations of subordinates in supervised work groups which were observed in a human participants interaction, we found evidence of nonlinear relation between the colleagues’ effort. In order to explain the large variability of behavior we observed, we consider those activated by unfavorable social comparison and propose a dynamical model. A theoretical dynamic model based on the empirical results appears to be powerful for modeling repeated interactions in a work group. Research and intervention design should focus on individual intolerance and beliefs about the reciprocal capacities between subordinates, which, according to our study, appear to play a key role in the inefficiency of equilibria observed in supervised work groups.
Convergence of Energy Minimizers of a MEMS Model in the Reinforced Limit
Authors: Laurençot Philippe , Nik Katerina , Walker Christoph 
Published: June 2021

AbstractEnergy minimizers to a MEMS model with an insulating layer are shown to converge in its reinforced limit to the minimizer of the limiting model as the thickness of the layer tends to zero. The proof relies on the identification of the $\Gamma $
Γ
-limit of the energy in this limit.
Epistemic Blame and the Normativity of Evidence
Authors: Schmidt Sebastian 
Published: June 2021

AbstractThe normative force of evidence can seem puzzling. It seems that having conclusive evidence for a proposition does not, by itself, make it true that one ought to believe the proposition. But spelling out the condition that evidence must meet in order to provide us with genuine normative reasons for belief seems to lead us into a dilemma: the condition either fails to explain the normative significance of epistemic reasons or it renders the content of epistemic norms practical. The first aim of this paper is to spell out this challenge for the normativity of evidence. I argue that the challenge rests on a plausible assumption about the conceptual connection between normative reasons and blameworthiness. The second aim of the paper is to show how we can meet the challenge by spelling out a concept of epistemic blameworthiness. Drawing on recent accounts of doxastic responsibility and epistemic blame, I suggest that the normativity of evidence is revealed in our practice of suspending epistemic trust in response to impaired epistemic relationships. Recognizing suspension of trust as a form of epistemic blame allows us to make sense of a purely epistemic kind of normativity the existence of which has recently been called into doubt by certain versions of pragmatism and instrumentalism.
In vitro targeting and selective killing of mcf-7 and colo320dm cells by 5-fluorouracil anchored to carboxylated SWCNTs and MWCNTs
Authors: Kamble Rutuja V. , Bhinge Somnath D. , Mohite Shrinivas K. , Randive Dheeraj S. , Bhutkar Mangesh A. 
Published: June 2021

AbstractThe intention of the present work was to synthesize the f-MWCNT and f-SWCNT terminated with proper functional group, loading of 5-Flurouracil and to perform cytotoxic activity. Functionalization of MWCNTs and SWCNTs was achieved through the acid treatment (H2SO4 + HNO3). 5-flurouracil was loaded into the prepared functionalized CNTs, thereafter; in vitro drug loading capacity and % drug release were calculated. Also the prepared f-CNTs, 5-flurouracil loaded CNTs were distinguished by using SEM, TGA, DSC, X-ray diffraction, Raman and FTIR spectroscopy. MCF-7 and COLO320DM cells were treated with selected concentrations of 5-FU loaded f-MWCNTs and f-SWCNTs to estimate the cytotoxic activity. It was observed that 5-FU loaded f-SWCNTs showed good activity against selected cell lines than others. Moreover, apoptosis percentage was reported to be 84.46 ± 4.3515 and 92.78 ± 2.6549 for 5-FU loaded f-SWCNTs against MCF-7 and COLO320DM cells respectively. It is evident from the results that the prepared drug loaded CNTs have comparable antitumor activity in cancer cell lines.
A Comparative Review of the Cell Biology, Biochemistry, and Genetics of Lactose Synthesis
Authors: Sadovnikova Anna , Garcia Sergio C. , Hovey Russell C. 
Published: June 2021

AbstractLactose is the primary carbohydrate in the milk of most mammals and is unique in that it is only synthesized by epithelial cells in the mammary glands. Lactose is also essential for the development and nutrition of infants. Across species, the concentration of lactose in milk holds a strong positive correlation with overall milk volume. Additionally, there is a range of examples where the onset of lactose synthesis as well as the content of lactose in milk varies between species and throughout a lactation. Despite this diversity, the precursors, genes, proteins and ions that regulate lactose synthesis have not received the depth of study they likely deserve relative to the significance of this simple and abundant molecule. Through this review, our objective is to highlight the requirements for lactose synthesis at the biochemical, cellular and temporal levels through a comparative approach. This overview also serves as the prelude to a companion review describing the dietary, hormonal, molecular, and genetic factors that regulate lactose synthesis.
Symmetric matrix ensemble and integrable hydrodynamic chains
Authors: Benassi Costanza , Dell’Atti Marta , Moro Antonio 
Published: June 2021

AbstractThe partition function of the Symmetric Matrix Ensemble is identified with the $$\tau $$
τ
-function of a particular solution of the Pfaff Lattice. We show that, in the case of even power interactions, in the thermodynamic limit, the $$\tau $$
τ
-function corresponds to the solution of an integrable chain of hydrodynamic type. We prove that the hydrodynamic chain so obtained is diagonalisable and admits hydrodynamic reductions in Riemann invariants in an arbitrary number of components.
Beyond feasibility—the role of motivation to implement measures to enhance resilience
Authors: Messmer Luzian , Thom Braida , Kruetli Pius , Dawoe Evans , Assefa Kebebew , Six Johan , Joerin Jonas 
Published: June 2021

AbstractMany regions around the world are experiencing an increase in climate-related shocks, such as drought. This poses serious threats to farming activities and has major implications for sustaining rural livelihoods and food security. Farmers’ ability to respond to and withstand the increasing incidence of drought events needs to be strengthened and their resilience enhanced. Implementation of measures to enhance resilience is determined by decisions of farmers and it is important to understand the reasons behind their behavior. We assessed the viability of measures to enhance resilience of farmers to drought, by developing a general framework that covers economic-technical and psychological-cognitive aspects, here summarized under the terms (1) motivation and (2) feasibility. The conceptual framework was applied to cocoa farmers in Ghana and tef farmers in Ethiopia by using questionnaire-based surveys. A portfolio of five specific measures to build resilience (i.e., irrigation, shade trees, fire belts, bookkeeping, mulching, early mature varieties, weather forecast, reduced tillage, improved harvesting) in each country was evaluated with a closed-ended questionnaire that covered the various aspects of motivation and feasibility whereby farmers were asked to (dis)agree on a 5-point Likert scale. The results show that if the motivation mean score is increased by 0.1 units, the probability of implementation increases by 16.9% in Ghana and by 7.7% in Ethiopia. If the feasibility mean score is increased by 0.1 units, the probability of implementation increases by 24.9% in Ghana and by 11.9% in Ethiopia. We can conclude that motivation and feasibility matter, and we improve our understanding of measure implementation if we include both feasibility and motivation into viability assessments.
A theoretically informed, mixed-methods study of pharmacists’ aspirations and readiness to implement pharmacist prescribing
Authors: Stewart Derek , Pallivalapila Abdulrouf , Thomas Binny , Hanssens Yolande , El Kassem Wessam , Nazar Zachariah , Al Hail Moza 
Published: June 2021

AbstractBackground Studies have highlighted advancing clinical pharmacy practice in Qatar. Objective To explore pharmacists’ aspirations and readiness to implement pharmacist prescribing. Setting Hamad Medical Corporation (HMC), the main provider of secondary and tertiary care. Method A sequential explanatory mixed-methods design. Questionnaire items were derived from the Consolidated Framework of Implementation Research (CFIR), in domains of: awareness/support; readiness; implementation; and facilitators and barriers. Following piloting, all pharmacists (n = 554) were invited to participate. Questionnaire data were analysed using descriptive and inferential statistics with principal component analysis of attitudinal items. Focus groups were recorded, transcribed and analysed using the Framework Approach. Main outcome measure Aspirations and readiness to implement pharmacist prescribing. Results The response rate was 62.8% (n = 348), with respondents highly supportive of implementation in Qatar (median 4, scale 0–5, extremely supportive). The majority (64.9%, n = 226) considered themselves ready, particularly those more senior (p < 0.05) and classifying themselves innovative (p < 0.01). Outpatient (72.9%, n = 221 agreeing) and inpatient (71.1%, n = 218 agreeing) HMC settings were those perceived as being most ready. PCA identified 2 components, with ‘personal attributes’ being more positive than ‘prescribing support’. Facilitators were access to records, organizational/management support and the practice environment, with physician resistance and scope of practice as barriers. Focus groups provided explanation, with themes in CFIR domains of innovation characteristics, characteristics of individuals and the inner setting. Conclusion HMC pharmacists largely aspire, and consider themselves ready, to be prescribers with inpatient and outpatient settings most ready. CFIR domains and constructs identified as facilitators and barriers should be focus for implementation.
Luck egalitarianism without moral tyranny
Authors: Spafford Jesse 
Published: June 2021

AbstractLuck egalitarians contend that, while each person starts out with a claim to an equal quantity of advantage, she can forfeit this claim by making certain choices. The appeal of luck egalitarianism is that it seems to satisfy what this paper calls the moral tyranny constraint. According to this constraint, any acceptable theory of justice must preclude the possibility of an agent unilaterally, discretionarily, and foreseeably leaving others with less advantage under conditions of full compliance with the theory. This paper argues that claim forfeiture is built into luck egalitarianism specifically to preclude such moral tyranny. However, it contends that the dominant interpretation of luck egalitarianism fails to fully satisfy the moral tyranny constraint. It offers an alternative interpretation that both eliminates the possibility of moral tyranny and rescues the position from two other prominent objections that have been directed against luck egalitarianism.