bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequent Hospital Users with Limited English are Vulnerable to COVID-19 Misinformation: Results from A Cross-sectional Survey
Authors: Jessup RL , Bramston C , Putrik P , Haywood C , Tacey M , Copnell B , Cvetanovska N , Cao Y , Gust A , Campbell D , Oldenburg B , Mehdi H , Kirk M , Zucchi E , Semciw AI , Beauchamp A 
Published: November 2021

Abstract
BackgroundSuccessful public health responses to pandemics rely on individuals being able to access, clearly understand and easily interpret relevant information about symptoms, prevention, testing and containment strategies. Accessing and interpreting information during the pandemic has been difficult for many populations, particularly those experiencing social or economic disadvantage. The aim of this study was to understand how a population of frequent hospital users originating, from a disadvantaged population, have accessed and interpreted information during the COVID pandemic in Melbourne.MethodsCross sectional telephone survey of 200 frequent hospital users (115 with limited English proficiency) informed by the World Health Organisation’s “Rapid, simple, flexible behavioural insights on COVID-19”. Primary outcome measures included knowledge of symptoms, preventive strategies, government restrictions aimed at containment, and belief in misleading information. Secondary outcome measure was perceived trustworthiness of information which was measured using content analysis of open-ended questions. ResultsOverall, the survey participants had poor understanding of misleading information (69%). 41.2% were unable to accurately identify symptoms, while 35.8% were unable to identify preventative strategies. Just under 1/3 (30.2%) were unable to describe government restrictions. English-speaking participants were almost three times (OR 2.69, 95%CI 1.47;4.91) more likely tohave adequate knowledge about symptoms, were twice as likely to understand local restrictions (OR 2.10 95%CI 1.06; 4.19) and were 11 times more likely to recognise information that was misleading or incorrect (OR 11.52 95%CI 5.39; 24.60) than those with limited English. 50% of those surveyed stated that theytrusted all information that they read or heard, with on 20% stating that they were uncertain or untrusting of some information.ConclusionLimited English proficiency was strongly associated with inadequate knowledge of COVID-19 and much greater likelihood of believing widely circulating misinformation. In order to reduce transmission, morbidity and mortality associated with COVID-19, health authorities must tailor health messaging to disadvantaged populations to ensure they have adequate access, and understanding, of the information.
Predictors of Hearing Functional Outcome following Surgery for Cerebellopontine Angle Meningioma.
Authors: Lekovic Gregory P. , Fatima Nida , Maxwell Anne K. , Mehta Gautam U. , Barnard Zachary R. , Wilkinson Eric P. , Brackmann Derald E. , Slattery William H. 
Published: November 2021

Abstract
OBJECTIVE

Cerebellopontine angle (CPA) meningioma can affect hearing function and require expeditious treatment to prevent permanent hearing loss. The authors sought to determine the factors associated with hearing functional outcome in CPA meningioma patients treated with surgery and/or radiation therapy either stereotactic radiosurgery or stereotactic radiation therapy.
METHODS

Consecutive patients with CPA meningioma who had presented at our hospital from 2008 to 2018 were identified through retrospective chart review. Hearing function-pure tone audiogram (PTA) and speech discrimination score (SDS)-was assessed before and after surgery for CPA meningioma. Hearing function with PTA>50 dB and SDS<69% were defined as poor hearing functional outcome. Multivariable Cox Proportional Hazards Regression model was used to assess the associations between pre-operative hearing functional assessment and post-operative hearing functional outcomes.
RESULTS

The study cohort included 31 patients (80.6% females, with a mean age of 61.3±15.2 years) with a median clinical follow-up of 5 months (range, 1 week-98 months). The mean pre-operative PTA and SDS were 23.8±11.2 dB and 64.4±22.2% respectively. At the last visit, there was a significant hearing recovery, with an improvement of 29.7±18.0 dB (p<0.001) and 87.6±17.8% (p<0.001) in PTA and SDS respectively. Multivariable cox proportional hazards regression model was conducted after adjusting for age, gender, tumor volume, location, and classification of the tumor, which revealed that patients undergoing surgery through retro sigmoid approach [Hazards Ratio (HR): 32.1, 95% Confidence Interval (CI): 2.11-491.0, p=0.01] and gross total resection (GTR) (HR: 2.99, 95%CI: 1.09-9.32, p=0.05) had significantly higher risk of poor hearing functional outcome. Moreover, patients with poor preoperative hearing had 85% higher chances of poor hearing functional outcome post operatively (HR: 0.15, 95%CI: 0.03-0.59, p=0.007).
CONCLUSION

Postoperative improvement in hearing is a reasonable expectation following surgery for CPA meningioma. Preoperative hearing, surgical approach and extent of surgical resection are predictive of postoperative hearing function outcome and can identify patients at higher risk of hearing loss.
Graph-Based Feature Reduction for Three-Dimensional Gabor Filter in PolSAR Image Classification
Authors: mohsen  
Published: November 2021

Abstract
Polarimetric Synthetic Aperture Radar (PolSAR) image classification is one of the most important applications in remote sensing. In this paper, the goal is PolSAR image classification and also introduce a method to obtain the best result for PolSAR image classification and recognition. In this article, we present the 3D-Gabor filters as a way in order to feature extraction of PolSAR images and get the best result with high accuracy for PolSAR image classification. Also, we prove that the 3D-Gabor filter approach can get higher accuracy than traditional methods for PolSAR images classification, but one of the most important challenges of 3D-Gabor filters is the number of features that are extracted from them. Therefore, by using 3D-Gabor filter we can't reach the optimal result because of the curse of dimensionality. So, to achieve the best results we propose a method to reduce the features that are extracted from 3D-Gabor filters. By using our proposed method, the features will be mapped to a new space with smaller dimensions. In the end, the experimental results indicate the superiority of the proposed method.
Improvement of 1,3-Propanediol Production From Crude Glycerol by Co-cultivation of Anaerobic and Facultative Microbes Under Non-strictly Anaerobic Conditions
Authors: Sun Yaqin , Liang Lingyun , Zheng Yafeng , Han Jindong , Xiu Zhilong 
Published: November 2021

Abstract
Background: Natural microbial consortia could efficiently produce 1,3-propanediol, the most promising bulk biochemical derived from glycerol that can be used as a monomer in the synthesis of polytrimethylene terephthalate (PTT). While natural microbial communities are made up of a diverse range of microbes with frequently unknown functions, the construction of synthetic microbial consortia allows for creating more defined systems with lower complexity.Results: In this study, the synthetic microbial consortia were constructed by combing facultative microbes of Klebsiella pneumoniae DUT2 (KP) and/or Escherichia coli DUT3 (EC) cultures with the strict anaerobic microbe of Clostridium butyricum DUT1 (CB) cultures under micro-aerobic conditions. The function of EC and KP during the fermentation process was to deplete oxygen and provide an anaerobic environment for CB. Furthermore, KP competes with CB to consume crude glycerol and produce 1,3-PDO. The interaction of commensalism and competition resulted in synthetic microbial consortia that could efficiently convert crude glycerol to 1,3-PDO even under micro-aerobic conditions. In a batch fermentation, the synthetic CB:KP co-culture at an initial abundance ratio of 92.5:7.5 yielded a maximum 1,3-PDO concentration of 52.08 g/L, with a yield of 0.49 g/g and a productivity of 1.80 g/(L.h), which increased by 10%, 9%, and 12%, respectively, when compared to the CB mono-culture under strictly anaerobic conditions. Compared to the KP mono-culture, the final 1,3-PDO concentration, yield, and productivity by the synthetic CB:KP consortia increased by 16%, 19%, and 84%, respectively. The synthetic CB:KP:EC co-culture achieved the highest 1,3-PDO flux of 49.17% at an initial abundance ratio of 85:7.5:7.5, while 7.43%, 5.77%, 3.15% 4.24%, and 2.13% of flux was distributed to butyric acid, acetic acid, lactic acid, ethanol, and succinic acid pathways. In a fed-batch fermentation, synthetic CB:KP:EC co-culture demonstrated a maximum 1,3-PDO concentration of 77.68 g/L with a yield of 0.51 g/g which is 30% and 13% higher than the production by the CB mono-culture at 0.02 vvm N2 supply. The initial abundance of CB guaranteed to be at least 85% facilitates 1,3-PDO production from crude glycerol efficiently by the development of synthetic microbial consortia. Conclusion: Under micro-aerobic conditions, the synthetic microbial consortia demonstrated excellent performance on 1,3-propanediol production via the interaction of commensalism and competition. The experimental results demonstrated the potential benefit of using the synthetic microbial consortia to produce 1,3-propanediol from crude glycerol.
Insights into fucose metabolism: SLC35C1-independent fucosylation discriminates against mannose-derived GDP-fucose
Authors: Skurska Edyta , Szulc Bożena , Maszczak-Seneczko Dorota , Wiktor Maciej , Wiertelak Wojciech , Olczak Mariusz 
Published: November 2021

Abstract
Mutations in the SLC35C1 gene, encoding the Golgi GDP-fucose transporter, cause leukocyte adhesion deficiency II (LADII). Fucosylation improvement in LADII patients treated with fucose suggests the existence of an SLC35C1-independent route of GDP-fucose transport, which still remains a mystery. Here, we developed and characterized a human cell-based model deficient in the SLC35C1 activity. The knockout cells displayed low but detectable levels of fucosylation. Strikingly, the fucosylation defect was almost completely reversed upon treatment with millimolar concentrations of fucose. Even if fucose was supplemented at nanomolar concentrations, it was still incorporated into glycans by the knockout cells. We also found that the SLC35C1-independent transport preferred the salvage pathway over the de novo pathway as a source of GDP-fucose. Our results imply that the Golgi systems of GDP-fucose transport discriminate between the substrate pools obtained from different metabolic pathways, which suggests a functional connection between nucleotide sugar transporters and nucleotide sugar synthetases.
Theoretical and Experimental Research on a Novel Method of Cluster Magnetorheological Finishing Based on Array Circular Holes Polishing Disk
Authors: Luo Bin , Yan Qiusheng , Chai Jingfu , Song Wenqing , Pan Jisheng 
Published: November 2021

Abstract
with the high performance of microelectronic and optoelectronic devices, the new generation of optoelectronic wafers is developing in the direction of large size and ultra-thinning, which requires ultra-smooth surfaces with sub-nanometer surface roughness. It puts forward new requirements and challenges for the efficient and ultra-smooth planarization processing of optoelectronic wafers. This paper proposes a novel method of cluster magnetorheological finishing based on array circular holes polishing disk, which can effectively improve the polishing shear force and polishing efficiency. The appropriate polishing shear force and material removal rate are the keys to achieve low roughness and low damage processing of optoelectronic wafers. Therefore, the shear force model of solid particles in magnetorheological finishing fluid is established based on the tribological principle. The material removal rate model is established by combining the polishing shear force model with the velocity model. The correctness of the above model is verified by the rotary dynamometer and repeated single-factor experiments. The errors between theoretical and experimental values of polishing shear force and material removal rate are 8.8% and 10.8%, respectively. The new magnetorheological finishing method can realize the efficient and ultra-smooth planarization of optoelectronic wafers. The established model can theoretically guide the optimization of the surface structure and polishing process of polishing disks.
Space-Time Model to Predict The Evolution of the Regional Subsidence in The Lacustrine Zone of Mexico City
Authors: Madrigal-Madrigal Maria Clara , Botero-Jaramillo Eduardo , Díaz-Ávalos Carlos 
Published: November 2021

Abstract
In several scientific and engineering disciplines, models have been used to understand the behavior of dynamic processes that evolve in space and in time by providing a probabilistic framework to analyzing the available information. The geostatistical tools used to analyze space-time data are based on established statistical methods, where time is considered as an additional dimension. These models have become very useful in fields such as meteorology, hydrology, ecology, geosciences, and environmental sciences, among others. Subsidence generated by the intense extraction of groundwater in a region is a dynamic phenomenon that manifests itself through the sinking of the ground surface, leading to significant settling in buildings and public utilities as well as cracks in roads. Since the regional subsidence of Mexico City is one of the most representative cases of this type in the world, in this work a model with a full grid space-time layout (STF) is used to analyze and predict the evolution of this phenomenon in the city, taking into account a monitoring system composed of 1931 surface benchmarks. Results show that the separable variogram model was the one that best represented the spatial and temporal correlation of the phenomenon in the area of study. In addition, the differences between the registered ground elevation made in 2016 and those estimated by the space-time model for the same year, were less than 1.00 m. This implies that in general accurate ground elevation values and subsidence rates can be obtained from the proposed space-time model during the time period 2010-2030 for the lacustrine zone of Mexico City.
Impulse Controllability Problem for the Equation of a String with an External Load on a Rectangle QT = [0 ≤ x ≤ π] × [0 ≤ t ≤ T].
Authors: Yevhenii Donchyk 
Published: November 2021

Abstract
In this paper necessary and sufficient conditions for impulse null-controllability and approximate null-controllability are obtained for the controllability problem for the equation of the string on a rectangle. This article discusses control that is carried out using an external load. Controls solving these problems are found explicitly.
Zimbabwe’s Indigenous SME policy Framework, a tool for black empowerment
Authors: Musabayana Godfrey Tambudzayi , Mutambara Emmanuel 
Published: November 2021

Abstract
Zimbabwe embarked on the policy to empower its local people through enacting into law a policy that targeted the empowerment of its citizens. The ‘Indigenisation and Empowerment Act’ (IEP) of Zimbabwe was made into law when the state President, Robert Mugabe signed the Act on March 7, 2008. It is stated in the (IEP) that the foreign-owned companies should offer at least 51 percent of their shares to indigenous Zimbabweans, and also provide for the creation of an empowerment fund to finance the acquisition of working capital, shares, and other forms of finance for indigenous people. The indigenisation process mainly focus on Small and Medium Enterprises (SMEs) as the key drivers of the new economic dispensation hence their performance is of great significance to this cause. This development was viewed by the citizens as the best strategy to implement in order to empower the nation to participate in the economic development of the country. Methodologically, the study critically analysed the literature of indigenization policies that were applied by some regions of the world and how they impacted on the disadvantaged groups. The researcher went on to analyse the Zimbabwean indigenous policies and how they impacted the SMEs and drew insights from the findings of other researchers.
Development of an Evidence-Based Exercise Program for Patients Undergoing Hematopoietic Stem Cell Transplantation
Authors: An Ki-Yong , Yu Mi-Seong , Cho Wonhee , Choi Meeok , Courneya Kerry , Cheong June-Won , Jeon Justin 
Published: November 2021

Abstract
PURPOSE

Although the efficacy of different exercise programs on different outcomes of hematopoietic stem cell transplantation (HSCT) patients have been examined, the details of process of exercise program development has not been described previously. In this study, we described the systematic development process of an evidence-based exercise program for HSCT patients.
METHODS

We developed the exercise program for HSCT patients using eight steps: (1) a literature review, (2) understanding patient characteristics, (3) first expert group discussion, (4) development of the first draft of the exercise program, (5) a pre-test, (6) second expert group discussion, (7) a pilot study, and (8) a focus group interview.
RESULTS

Through six systematic steps, tailored exercise program was developed based on patients’ physical and hospital room conditions, which varies in intensity (three different intensities) and exercise positions (supine, sitting, and standing). Then, a pilot randomized trial was conducted on 21 patients with HSCT patients. The adherence rate to exercise program was 44.7% and significantly better timed up and go and symptom scale were seen in the exercise group compared than those of control group. Through the last step, three barriers and four facilitators of exercise during HSCT were identified.
CONCLUSION

A safe and feasible tailored unsupervised exercise program for patients during HSCT was developed and tested. In the future, the efficacy of the exercise program should be tested with RCT with implementation strategies to reduce exercise barriers and maximize facilitators of exercise identified in the current study.
Sijunzi Tang Enhances The Sensitivity of Lung Cancer Cells To Gefitinib Based On Glutamine Metabolism
Authors: Wang Zhihong , Wang Shiyuan , Liu Xia , Cao Bo , Zhang Mingyu , Li Chunyu , Li Guohui 
Published: November 2021

Abstract
Background: Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) has been the major bottleneck that limits the long-term clinical efficacy. Therefore, the exploration of novel strategies for the treatment of non-small cell lung cancer (NSCLC) is urgent. Sijunzi Tang (SJZ) has been usually used as a complementary therapy for cancer patients that can prolong their overall life. Nevertheless, its underlying mechanism when combined with EGFR-TKIs is not clear. Methods: Here, the anti-tumor activity was evaluated by determining cell viability by using the Cell Counting Kit-8 (CCK-8). A high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was established to simultaneously quantify nine metabolites in the glutamine metabolic pathway, such as glutamine, glutamate, αketoglutaric acid, fumarate, succinate, citrate, cis-aconitate, alanine, and malate in PC-9/GR cells. Results: The results showed that SJZ could enhance the sensitivity of lung cancer cells to gefitinib. The content of glutamine and glutamate in the SJZ/gefitinib group was significantly lower than that in the gefitinib group, while the concentration of other metabolites did not change significantly. Conclusion: In summary, SJZ can reverse gefitinib resistance by modulating glutamine metabolism. Our results suggested that SJZ might be a potential resistance reversal herbal medicine and combined with gefitinib might be a promising strategy for the therapy of lung cancer. Also, the research will provide novel insights for the study of the mechanisms on Traditional Chinese medicine (TCM) prescriptions-reversed resistance of EGFR-TKIs, and scientific basis for the combined treatment of lung cancer with TCM and EGFR-TKIs.
Management of Pancreatic Trauma In Urban India: A Multicenter Study
Authors: Bavishi Devi , Khajanchi Monty , Prajapati Ramlal , Gadgil Anita , Sarang Bhakti , Soni Kapil Dev , Banker Amay , Moghe Dhanashree , Wärnberg Martin Gerdin 
Published: November 2021

Abstract
Background: Pancreatic trauma occurs in 0.2-2% of patients with blunt trauma and 1–12% of patients with penetrating trauma. The mortality and morbidity rates range from 9-34% and 30-60% respectively. We aimed to review the management of pancreatic trauma in a multicenter database from India.Methods: We analyzed all patients who suffered a pancreatic injury and who were included in the multicenter prospective observational study ‘Towards Improved Trauma Care Outcomes (TITCO)’.Results: Of the 16047 trauma cases, 1134 (7.1%) patients suffered abdominal trauma. Of all those with abdominal trauma 55 patients (4.9%) had injury to the pancreas. 28 patients (50.9%) with pancreatic trauma were managed conservatively. 27 patients (49.1%) underwent surgical exploration in the form of laparotomies. 11 procedures were undertaken for pancreas. A total of 45 (82%) patients had associated injuries along with pancreatic injury. Thorax (19) (including injuries to lung, pleura and ribs), liver (17), bowel (14) and spleen (13) were the most common associated injuries.Conclusion: Conservative management was as common as operative management in patients with pancreatic injuries. Most (80%) grade III/IV underwent operative treatment. Many patients (82%) had associated injuries. Level of evidence: III
Nitrogen-metabolising Microorganism Analysis in Rapid Sand Filters From Drinking Water Treatment Plant by Culturing and Metagenomics
Authors: Gu Qihui , Ma Jun , Zhang Jumei , Guo Weipeng , Wu Huiqing , Sun Ming , Wang Juan , Wei Xianhu , Zhang Youxiong , Chen Montong , Xue Liang , Ding Yu , Wu Qingping 
Published: November 2021

Abstract
Sand filter (SFs) are common treatment processes for nitrogen pollutants removal in drinking water treatment plants (DWTPs). However, the mechanisms on the nitrogen-cycling role of SFs are still unclear. In this study, 16S rRNA gene amplicon sequencing was used to characterise the diversity and composition of the bacterial community in SFs from DWTPs. Additionally, metagenomics approach was used to determine the functional microorganisms involved in nitrogen cycle in SFs. Our results showed that Proteobacteria, Acidobacteria, Nitrospirae, and Chloroflexi dominated in SFs. Subsequently, 85 high-quality metagenome-assembled genomes (MAGs) were retrieved from metagenome datasets of selected SFs involving nitrification, assimilatory nitrogen reduction, and denitrification processes. Read mapping to reference genomes of Nitrospira and the phylogenetic tree of the ammonia monooxygenase subunit A gene, amoA, suggested that Nitrospira is abundantly found in SFs. Furthermore, according to their genetic content, a nitrogen metabolic model in SFs was proposed using representative MAGs and pure culture isolates. Quantitative real-time polymerase chain reaction (PCR) showed that ammonia-oxidising bacteria (AOB) and archaea (AOA), and complete ammonia oxidisers (comammox) were ubiquitous in the SFs, with the abundance of comammox being higher than that of AOA and AOB. Moreover, we identified a bacterial strain with a high NO3-N removal rate as Pseudomonas sp., which could be applied in the bioremediation of micro-polluted drinking water sources. Our study provides insights into functional nitrogen-metabolising microbes in SFs of DWTPs.