bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Insights Into the Interaction Between the Autonomic Nervous System and Inflammation on Coronary Physiology: A Quantitative Flow Ratio Study
Authors: Wang Jun , Liu Wei , Chen Huaqiang , Liu Chengzhe , Wang Meng , Chen Hu , Zhou Huixin , Liu Zhihao , Zhang Song , Yu Zhongyang , Duan Shoupeng , Deng Qiang , Sun Ji , Jiang Hong , Yu Lilei 
Published: July 2021

Background: Heart rate variability (HRV) was proposed as a noninvasive biomarker to stratify the risk of cardiovascular disease. However, it remains to be determined if HRV can be used as a surrogate for coronary artery physiology as analyzed by quantitative flow ratio (QFR) in patients with new-onset unstable angina pectoris (UAP).Methods: A total of 129 consecutive patients with new-onset UAP who underwent 24-h long-range 12-channel electrocardiography from June 2020 to December 2020 were included in this study. HRV, coronary angiography, and QFR information was retrieved from patient medical records, the severity of coronary lesions was evaluated using the Gensini score (GS), and total atherosclerotic burden was assessed using the three-vessel contrast QFR (3V-cQFR) calculated as the sum of cQFR in three vessels.Results: Multivariate logistic analysis showed that low-frequency power (LF) and high-sensitivity C-reactive protein (hs-CRP) were directly correlated with functional ischemia of target vessel, which were inversely correlated with total atherosclerotic burden as assessed by 3V-cQFR. Moreover, incorporation of the increase in LF into the existing model that uses clinical risk factors, GS, and hs-CRP significantly increased the discriminatory ability for evaluating coronary artery physiology of target vessel.Conclusions: LF and hs-CRP are independently associated with functional ischemia in patients with new-onset UAP. The relative increase of LF and hs-CRP could add value to the use of classical cardiovascular risk factors to predict the functional severity of coronary artery stenosis. Our results suggest a potential association between the autonomic nervous system, inflammation, and coronary artery physiology.
Deuteron Chemical Exchange Saturation Transfer for the Detection of Slow Motions in Rotating Solids
Authors: Vugmeyster Liliya , Ostrovsky Dmitry , Greenwood Alexander , Fu Riqiang 
Published: July 2021

We utilized the 2H Chemical Exchange Saturation Transfer (CEST) technique under magic angle spinning (MAS) conditions to demonstrate the feasibility of the method for studies of slow motions in the solid state. For the quadrupolar anisotropic interaction, the essence of CEST is to scan the saturation pattern over a range of offsets corresponding to the entire spectral region(s) for all conformational states involved, which translates into a range of −60–+ 60 kHz for methyl groups. Rotary resonances occur when the offsets are at half-and full-integer of the MAS rates. The choice of the optimal MAS rate is governed by the condition to reduce the number of rotary resonances in the CEST profile patterns and retain a sufficiently large quadrupolar interaction active under MAS to maintain sensitivity to motions. As examples, we applied this technique to a well-known model compound dimethyl-sulfone (DMS) as well as amyloid-β fibrils selectively deuterated at a single methyl group of A2 belonging to the disordered domain. It is demonstrated that the obtained exchange rate between the two rotameric states of DMS at elevated temperatures fell within known ranges and the fitted model parameters for the fibrils agree well with the previously obtained value using static 2H NMR techniques. Additionally, for the fibrils we have observed characteristic broadening of rotary resonances in the presence of conformational exchange, which provides implications for model selection and refinement. This work sets the stage for future potential extensions of the 2H CEST under MAS technique to multiple-labeled samples in small molecules and proteins.
vHIT Testing of Vertical Semicircular Canals With Goggles Yield Different Results Depending on Which Canal Plane Being Tested
Authors: Wittmeyer Cedervall Louise , Magnusson Måns , Karlberg Mikael , Fransson Per-Anders , Nyström Anastasia , Tjernström Fredrik 
Published: July 2021

Objective: The use of goggles to assess vertical semicircular canal function has become a standard method in vestibular testing, both in clinic and in research, but there are different methods and apparatus in use. The aim of this study was to determine what the cause of the systematic differences is between gain values in testing of the vertical semicircular canals with two different video head impulse test (vHIT) equipment in subjects with normal vestibular function.Study Design: Retrospective analysis of gain values on patients with clinically deemed normal vestibular function (absence of a corrective eye saccade), tested with either Interacoustics or Otometrics system. Prospective testing of subjects with normal vestibular function with the camera records the eye movements of both eyes. Finally, 3D sensors were placed on different positions on the goggles measuring the actual vertical movement in the different semicircular planes.Results: In the clinical cohorts, the gain depended on which side and semicircular canal was tested (p &lt; 0.001). In the prospective design, the combination between the stimulated side, semicircular canal, and position of the recording device (right/left eye) highly influenced the derived gain (p &lt; 0.001). The different parts of the goggles also moved differently in a vertical direction during vertical semicircular canal testing.Conclusion: The gain values when testing the function of the vertical semicircular canals seem to depend upon which eye is recorded and which semicircular plane is tested and suggests caution when interpreting and comparing results when different systems are used both clinically as well as in research. The results also imply that further research and development are needed to obtain accurate vertical semicircular canal testing, in regard to both methodology and equipment design.
Lateralization of Motor Signs Affects Symptom Progression in Parkinson Disease
Authors: Elkurd Mazen , Wang Jijia , Dewey Richard B. 
Published: July 2021

Background: Asymmetry of motor signs is a cardinal feature of Parkinson disease which may impact phenotypic expression.Objective: To investigate the relationship between lateralization of motor signs and symptom progression and severity during longitudinal observation for up to 4 years in a naturalistic study.Methods: We analyzed data prospectively collected during the NINDS Parkinson Disease Biomarker Project (PDBP). We defined the Movement Disorder Society Revision of the Unified Parkinson Disease Rating Scale (MDS-UPDRS) part II as the primary measure of symptom progression. Left side predominant subjects were those whose lateralized motor scores on the MDS-UPDRS part III were ≥2 points higher on the left side than on the right side of the body. Multiple regression models (controlled for age, gender, education years, ethnicity, levodopa equivalent daily dose (LEDD) at baseline, and years with PD) were used to estimate the rate of symptom progression comparing left predominant (LPD) with non-left predominant (NLPD) subjects. A sensitivity analysis was performed using the same multiple regression models in the subgroups of low (0–26) or high (&gt;27) MDS-UPDRS II score at baseline to determine if PD severity influenced the results.Results: We included 390 participants, 177 LPD and 213 NLPD. We found that MDS-UPDRS part II progression from baseline to 48 months was faster in LPD compared to NLPD (0.6 points per year faster in LPD, p = 0.05). Additionally, the LPD group was statistically significantly worse at baseline and at 48 months in several subparts of the MDS-UPDRS and the Parkinson's Disease Questionnaire-39 (PDQ-39) mobility score. Significantly slower progression (difference of −0.8, p = 0.01) and lower score at 48 months (difference of −3.8, p = 0.003) was seen for NLPD vs. LPD in the group with lower baseline MDS-UPDRS part II score.Conclusion: Left side lateralization was associated with faster symptom progression and worse outcomes in multiple clinical domains in our cohort. Clinicians should consider using motor predominance in their counseling regarding prognosis.
Chinese Herbal Medicine for Irritable Bowel Syndrome: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials
Authors: Zheng Hui , Jin Song , Shen Yin-Li , Peng Wen-Yan , Ye Kun , Tang Tai-Chun , Zhao Jun , Chen Min , Li Zhi-Gang 
Published: July 2021

Purpose: Chinese herbal medicine (CHM) is an important complementary and alternative therapy for the management of irritable bowel syndrome (IBS). Previous meta-analyses suggested that CHM is effective for IBS; nonetheless, its effectiveness is inconclusive owing to repeated significance testing. We aimed to examine the efficacy and safety of CHM for IBS through a meta-analysis and trial sequential analysis (TSA).Methods: We searched OVID Medline, Embase, Cochrane Central Register of Controlled Trials, and Web of Science from January 1, 1980, to September 20, 2020. The primary outcome was adequate relief of global IBS symptoms. The secondary outcomes included relief of abdominal pain and treatment-related adverse events. The relative ratio (RR) and required information size (RIS) were calculated for each outcome.Results: Ten trials recruiting 2,501 participants were included. Seven (70%) trials were at low risk of bias (RoB). Compared with placebo, CHM was associated with a significantly higher proportion of adequate relief of global IBS symptoms [RR 1.76 (95% confidence interval (95%CI), 1.33–2.33); I2 = 81.1%; p &lt; 0.001]. The RIS was 1,083 for the primary outcome, and the accrued information size was 1,716. The analysis of the relief of abdominal pain (three trials with 916 participants) showed similar results compared with placebo [RR 1.85 (95%CI, 1.59–2.14); I2 = 0%; p &lt; 0.001; RIS = 197 participants]. CHM was associated with a higher proportion of adverse events compared with placebo [RR 1.51 (95%CI, 1.14–2); I2 = 0%; p = 0.004].Conclusion: CHM was effective in relieving IBS symptoms but caused a higher adverse event rate than placebo. TSA analysis confirmed the findings with sufficient information size.
A Functional Radiological and Soft Tissue Classification to Predict Outcomes in Orbital Fracture Surgery in a Multidisciplinary “Real-World” Setting
Authors: Yang Elizabeth , Chan Shu-Yi Claire , Al-Omari Yara , Ward Louise , Yap Timothy E. , Jhass Aneka , Pancholi Ravi , Aziz Ahmad , Bentley Christopher Richard , Perry Michael , Lee Vickie 
Published: July 2021

Purpose: The decision for open reduction and internal fixation (ORIF) of orbital fractures is usually based on clinical severity and soft tissue and bony findings. This study aimed to identify prognostic factors for a successful surgical outcome.Materials and Methods: We included all orbital fractures treated by ORIF referred to the Ophthalmology clinic for assessment over a 12-year period. A successful outcome was defined as (i) a single operation, (ii) improved diplopia and globe position at 6 months, (iii) no surgical complications, and (iv) patient satisfaction. Data was collected on presenting symptoms, orthoptic measurements, time interval from injury to surgery, fracture geometry and involvement of internal, and external bony landmarks. Univariate and multivariate regression was used to identify predictive factors for success.Results: There were 143 cases with median age 35.4 years and 81.8% (117/143) male. 51% (73/143) were complex fractures involving multiple orbital walls. 63.6% (91/143) achieved significant improvement in both enophthalmos and diplopia at 6 months. 15.3% (22/143) had significant preoperative soft tissue or neurogenic injury. 11.8% (17/143) required orbital plate repositioning or removal. 1.4% (2/143) developed orbital haematoma and 4.2% (6/143) had cicatricial entropion. Pre-operative nerve or muscle damage (OR 0.05, p = 0.01) and infraorbital fissure fracture (OR 0.38, p = 0.04) were associated with poor outcomes, whereas an intact posterior ledge was associated with successful outcomes (OR 3.03, p = 0.02).Conclusion: Careful ocular motility evaluation to ascertain neurogenic injury and muscle compartment syndrome, and radiological analysis of the integrity of the posterior ledge and the inferior orbital fissure can facilitate management and expectations of ORIF surgery.
Взаємозалежність дезадаптації та прокрастинації державних службовців в різні періоди кар'єрного зростання
Authors: Kotlyar Lyudmila 
Published: July 2021

Стаття присвячена проблемі взаємозалежності дезадаптації та прокрастинації державних службовців, виявленню основних підходів. Процес адаптації передбачає резерви державних службовців щодо забезпечення управлінської діяльності та існування в умовах підвищеної стресогенності зовнішнього середовища, яке постійно змінюється. Дезадаптація державних службовців призводить до порушення взаємодії з середовищем, посилювання проблемних ситуацій в управлінській діяльності та супроводжується міжособистісними і внутрішньоособистісними конфліктами в різні періоди кар’єрного зростання. Діагностичними критеріями дезадаптації державних службовців є порушення в професійній діяльності в різні періоди кар’єрного зростання та в міжособистісній сфері.
Дезадаптація як процес, що посилює проблемні ситуації в управлінській діяльності та супроводжується міжособистісними і внутрішньоособистісними конфліктами є предиктором прокрастинації державних службовців в різні періоди кар’єрного зростання. У результаті аналізу наукових джерел визначено сутність та основні ознаки дезадаптації та прокрастинації державних службовців. Розглянуті та проаналізовані актуальні наукові підходи до визначення понять. З’ясовані основні аспекти вищевказаних явищ показали, що феномен прокрастинації є негативне явище, яке перешкоджає суспільному розвитку і розуміється як постійне відкладання важливих справ та прийняття рішень, що завжди повторюються всупереч усвідомленню державними службовцями негативних наслідків та неготовністю взяти на себе відповідальність.
Висновком є те, що в процесі дезадаптації державні службовці менш енергетично обдаровані, не досить гнучкі та мобільні, а проблемні ситуації, міжособистісні та внутрішньоособистісні конфлікти, які виникають в різні періоди кар’єрного зростання, підвищують рівень прокрастинації виконання справ і прийняття рішень. Показниками дезадаптації державних службовців є: нездатність до формування нового гомеостатичного стану під час взаємодії організму та середовища; нездатність забезпечення дільності в умовах підвищеної стресогенності зовнішнього середовища, що постійно змінюється; нездатність враховувати особливості середовища й активно впливати на нього; низький рівень суб’єктивного відчуття благополуччя; об’єктивна або суб’єктивна неможливість самореалізації та досягнення значимих цілей.
Проявами прокрастинації державних службовців в різні періоди кар`єрного зростання є: відволікання з причини розсіяної уваги і неможливістю зібратися; недбалість і поспішність в процесі виконання справ і прийняття рішень; негативний вплив Інтернету, який постійно відволікає від виконання справ і прийняття рішень; імпульсивність, яка ускладнює контроль поведінки та планування дій відповідно до мети; різноспрямована пошукова поведінка, що приводить до порушення цілепокладання.
Literatura infanto - juvenil para a valorização da Cultura Negra
Authors: Velloso Laila Vilela , E Silva Dagmar Mello , Mariani Braz Ruth Maria 
Published: July 2021

A literatura é um produto cultural. Devemos estar atentos ao que é oferecido aos estudantes, de forma que escola e literatura caminhem juntas para formação humana amparadas em valores de respeito à diversidade, às diferenças e à inclusão. Este trabalho tem como objetivo realizar um levantamento de livros de literatura infanto-juvenil cujas narrativas, atendam princípios de uma formação leitora, atenta aos Direitos Humanos. Assim, fizemos a seleção de dez obras que tratam de temas relacionados à Diversidade e Inclusão de forma a apoiar o desenvolvimento de oficinas de leitura voltadas para crianças do 1º segmento do ensino. Este estudo descritivo, qualitativo, de cunho pedagógico é definido como uma pesquisa que envolve o planejamento e a implementação de interferências (mudanças, inovações pedagógicas). A seleção foi realizada a partir dos títulos e do conteúdo que tratavam: as questões étnico-raciais. Como produto, apresentamos um catálogo online com as indicações de obras literárias que contribuam para a formação do leitor na perspectiva aqui apontadas. A partir de Freire e Foucault, verificamos que a literatura, nas escolas, pode agenciar modos de rupturas com práticas discursivas – jogos de verdade – que naturalizam modos de existência, excluindo os que não se enquadram nessas exigências naturalizadas por determinados discursos
PEMBOBOTAN MENGGUNAKAN PAIRWISE COMPARISON PADA CASE BASED REASONING REKOMENDASI HOTEL
Authors: Iman Kukuh Tri Nur , Wibisono Setyawan 
Published: July 2021

Meningkatnya pertumbuhan hotel di kota Semarang, maka akan mengakibatkan peningkatan terhadap pilihan hotel di kota Semarang. Setiap hotel memiliki penawaran layanan yang berbeda-beda seperti kelas hotel dan fasilitas yang terdapat di hotel tersebut. Untuk memudahkan dalam pemilihan hotel dibutuhkan sistem rekomendasi yang bisa digunakan dalam memilih hotel di kota Semarang. Dalam mengembangkan penelitian ini, digunakan model penalaran dengan metode Case Based Reasoning (CBR). Metode CBR berguna untuk membuat pilihan rekomendasi hotel terbaik dengan cara membandingkan antara fasilitas-fasilitas yang dikehendaki dengan fasilitas-fasilitas yang dimiliki oleh setiap hotel. Fasilitas hotel dikategorikan dalam tiga kelompok, yaitu: fasilitas utama, fasilitas umum dan fasilitas tambahan. Setiap fasilitas diberikan bobot secara subjektif dengan menentukan kelebihpentingan antara satu fasilitas dibandingkan dengan fasilitas yang lain. Dalam penentuan kelebihpentingan setiap fasilitas tetap mempertimbangkan penilaian umum dalam bidang perhotelan Nilai-nilai subjektif tersebut diuji validitasnya menggunakan metode pairwise comparison. Pada penelitian ini hasil perhitungan pairwise comparison didapatkan bahwa bobot untuk fasilitas utama sebesar 0,63, bobot untuk fasilitas umum sebesar 0,24 serta bobot untuk fasilitas tambahan sebesar 0,13.Hasil perbandingan pada CBR akan dihitung nilai kedekatannya menggunakan algoritma similaritas K–Nearest Neighbors (KNN) sehingga akan memberikan nilai kemiripan antara parameter dan hasil rekomendasi pemilihan hotel. Hasil nilai akhir similaritas berada dalam rentang antara 0 sampai dengan 1. Sistem ini akan merekomendasikan beberapa hotel dengan similaritas lebih dari 0,4 sedangkan similaritas kurang dari 0,4 akan akan ditambahkan ke dalam tabel revise supaya bisa dicarikan solusi.
DIRECTED READING ACTIVITY (DRA) APPLICATION IN ENGLISH READING COMPREHENSION CLASSROOM
Authors: Munandar Imam , Srimurni Srimurni 
Published: July 2021

This research manages to analyze the effectiveness of DRA in enhancing students ‘skill in reading comprehension. The researchers carried out the research at SMP N 4 Takengon, in which they found that teachers faced some problems in teaching reading comprehension to students. To figure out the answer, the research applies quantitative research with experimental approach. After statistically obtaining and interpreting the data, the study concludes that Directed Reading Activity (DRA) method is able to increase students reading comprehension skill. This is because that Directed Reading Activity (DRA) is a teacher strategy in reading comprehension that emphasizes on instructional support before, during, and aftermath the reading. Meanwhile, the research found that this strategy is also able to increase and build stronger student vocabulary and reading skill. In conclusion, the DRA strategy is effective in improving students’ ability in reading comprehension, and also building their vocabulary.
Pengaruh Kualitas Pelayanan Terhadap Kepuasan Pelanggan PT. Langit Membiru Wisata Bogor
Authors: Ardista Rini 
Published: July 2021

This research aims to determine and analyze the effect of service quality on customer satisfaction of PT. Langit Membiru Wisata Bogor, to find out how big the influence and relationship between service quality and customer satisfaction. The sample used was 100 respondents taken through t-test or interviews, observations, and questionnaires at PT. Langit Membiru Wisata Bogor and the primary data source processed with SPSS 25. The t-test results show the effect of service quality on customer satisfaction, this is evidenced by the variable (X) service quality and variable (Y) customer satisfaction has a value less than 0.05, namely (0.00 <0.05), this is proven with the value in the t test obtained t count 91.624> t table 5.293, so it can be concluded that the hypothesis can be accepted.
Abstrak
Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh kualitas pelayanan terhadap kepuasan pelanggan PT. Langit Membiru Wisata Bogor, untuk mengetahui seberapa besar pengaruh dan hubungan antara kualitas pelayanan dengan kepuasan pelanggan. Sampel yang digunakan adalah 100 responden yang diambil melalui uji-t atau wawancara, observasi, dan angket pada PT. Langit Membiru Wisata Bogor dan sumber data primer diolah dengan SPSS 25. Hasil uji t menunjukkan adanya pengaruh kualitas pelayanan terhadap kepuasan pelanggan, hal ini dibuktikan dengan variabel (X) kualitas pelayanan dan variabel (Y) kepuasan pelanggan memiliki nilai lebih kecil dari 0,05 yaitu (0,00 < 0,05) hal ini terbukti dengan nilai pada uji t diperoleh t hitung 91,624 > ttabel 5,293, sehingga dapat disimpulkan bahwa hipotesis dapat diterima.
Fast Magnetic Wave Could Heat the Solar Low-beta Chromosphere
Authors: Wang Yikang , Yokoyama Takaaki , Iijima Haruhisa 
Published: July 2021

Abstract
Magnetohydrodynamic (MHD) waves are candidates for heating the solar chromosphere, although it is still unclear which mode of the wave is dominant in heating. We perform two-dimensional radiative MHD simulation to investigate the propagation of MHD waves in the quiet region of the solar chromosphere. We identify the mode of the shock waves by using the relationship between gas pressure and magnetic pressure across the shock front and calculate their corresponding heating rate through the entropy jump to obtain a quantitative understanding of the wave-heating process in the chromosphere. Our result shows that the fast magnetic wave is significant in heating the low-beta chromosphere. The low-beta fast magnetic waves are generated from high-beta fast acoustic waves via mode conversion crossing the equipartition layer. Efficient mode conversion is achieved by large attacking angles between the propagation direction of the shock waves and the chromospheric magnetic field.