bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sparse data-based image super-resolution with ANFIS interpolation
Authors: Ismail Muhammad , Shang Changjing , Yang Jing , Shen Qiang 
Published: September 2021

AbstractImage processing is a very broad field containing various areas, including image super-resolution (ISR) which re-represents a low-resolution image as a high-resolution one through a certain means of image transformation. The problem with most of the existing ISR methods is that they are devised for the condition in which sufficient training data is expected to be available. This article proposes a new approach for sparse data-based (rather than sufficient training data-based) ISR, by the use of an ANFIS (Adaptive Network-based Fuzzy Inference System) interpolation technique. Particularly, a set of given image training data is split into various subsets of sufficient and sparse training data subsets. Typical ANFIS training process is applied for those subsets involving sufficient data, and ANFIS interpolation is employed for the rest that contains sparse data only. Inadequate work is available in the current literature for the sparse data-based ISR. Consequently, the implementations of the proposed sparse data-based approach, for both training and testing processes, are compared with the state-of-the-art sufficient data-based ISR methods. This is of course very challenging, but the results of experimental evaluation demonstrate positively about the efficacy of the work presented herein.
Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis 2020
Authors: Tokushige Katsutoshi , Ikejima Kenichi , Ono Masafumi , Eguchi Yuichiro , Kamada Yoshihiro , Itoh Yoshito , Akuta Norio , Yoneda Masato , Iwasa Motoh , Yoneda Masashi , Otsuka Motoyuki , Tamaki Nobuharu , Kogiso Tomomi , Miwa Hiroto , Chayama Kazuaki , Enomoto Nobuyuki , Shimosegawa Tooru , Takehara Tetsuo , Koike Kazuhiko 
Published: September 2021

AbstractNonalcoholic fatty liver disease (NAFLD) has become a serious public health issue not only in Western countries but also in Japan. Within the wide spectrum of NAFLD, nonalcoholic steatohepatitis (NASH) is a progressive form of disease that often develops into liver cirrhosis and increases the risk of hepatocellular carcinoma (HCC). While a definite diagnosis of NASH requires liver biopsy to confirm the presence of hepatocyte ballooning, hepatic fibrosis is the most important prognostic factor in NAFLD. With so many NAFLD patients, it is essential to have an effective screening method for NAFLD with hepatic fibrosis. As HCC with non-viral liver disease has increased markedly in Japan, effective screening and surveillance of HCC are also urgently needed. The most common death etiology in NAFLD patients is cardiovascular disease (CVD) event. Gastroenterologists must, therefore, pay close attention to CVD when examining NAFLD patients. In the updated guidelines, we propose screening and follow-up methods for hepatic fibrosis, HCC, and CVD in NAFLD patients. Several drug trials are ongoing for NAFLD/NASH therapy, however, there is currently no specific drug therapy for NAFLD/NASH. In addition to vitamin E and thiazolidinedione derivatives, recent trials have focused on sodium glucose co-transporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) analogues, and effective therapies are expected to be developed. These practical guidelines for NAFLD/NASH were established by the Japanese Society of Gastroenterology in conjunction with the Japan Society of Hepatology. Clinical evidence reported internationally between 1983 and October 2018 was collected, and each clinical and background question was evaluated using the Grades of Recommendation Assessment, Development and Evaluation (GRADE) system. This English summary provides the core essentials of these clinical practice guidelines, which include the definition and concept, screening systems for hepatic fibrosis, HCC and CVD, and current therapies for NAFLD/NASH in Japan.
Generalized Kramers–Kronig relations and sum rules for moments and powers of degenerate four wave mixing susceptibility
Authors: Saarinen Jarkko J. 
Published: September 2021

AbstractGeneralized Kramers–Kronig (K–K) type dispersion relations and sum rules are derived in the static limit for the moments of the degenerate four wave mixing susceptibility. The degenerate nonlinear susceptibility is different from a typical use of the conventional K–K dispersion relations, which assume absence of complex poles of a function in the upper half of complex frequency plane, whereas degenerate susceptibility has simultaneous poles in both half planes. In the derivation of the generalized K–K relations the poles and their order are taken into account by utilization of the theorem of residues. The conventional K–K relations can be used to estimate the real and imaginary parts of the second and higher powers of the susceptibility as the effect of the poles is reduced due to a faster convergence of the dispersion relations. The present theory is directly applicable to higher order susceptibilities and can be used in testing of theoretical models describing the degenerate four wave mixing susceptibility in nonlinear optical and terahertz spectroscopy.
Pillenmüdigkeit? Fakten und Auswirkungen
Authors: Tschudin Sibil 
Published: September 2021

Zusammenfassung
Hintergrund
In den letzten Jahren scheint sich ein Trend zu Alternativen für die „Pille“ abzuzeichnen.

Fragestellung
Es stellt sich die Frage, was es mit der postulierten „Pillenmüdigkeit“ auf sich hat, ob tatsächlich eine Abkehr von der hormonellen Kontrazeption stattfindet, was mögliche Gründe dafür sein könnten und ob sich Auswirkungen feststellen lassen.

Material und Methoden
Es wurde eine Literaturrecherche zu folgenden Punkten durchgeführt: 1. Hinweise auf Veränderungen im Verhütungsverhalten in Deutschland, Österreich und der Schweiz, 2. Evidenz in Bezug auf die zurzeit viel diskutierten Auswirkungen hormoneller Kontrazeptiva auf Psyche und Sexualität und 3. Hinweise auf eine Zunahme der Schwangerschaftsabbrüche.

Ergebnisse
Die Verwendung der Pille zeigt eine rückläufige Tendenz. Zurzeit lässt sich keine Aussage machen, ob es zu einer signifikant häufigeren Anwendung der Kupferspirale gekommen ist. Die Sorge vor Nebenwirkungen ist für einen beträchtlichen Prozentsatz der befragten Frauen ein wesentlicher Grund, hormonelle Verhütungsmittel zu vermeiden. Gemäß aktuellen Übersichtsbeiträgen verzeichnen die meisten Frauen, die kombinierte orale Kontrazeptiva verwenden, keine oder eine positive Wirkung auf die Stimmung, die Inzidenz einer depressiven Symptomatik ist gering und nur in Untergruppen relevant. Die Auswirkungen hormoneller Kontrazeptiva auf die Sexualität der Frau sind nicht ausreichend untersucht und die verfügbaren Daten deuten darauf hin, dass nur eine Minderheit eine positive oder negative Veränderung wahrnimmt. Eine Zunahme der Schwangerschaftsabbrüche zeichnet sich nicht ab.

Schlussfolgerung
In Anbetracht des Stellenwerts, den unter anderem die Nebenwirkungen bezüglich Zufriedenheit mit und Adhärenz zur Verhütungsmethode haben, ist eine individuell zugeschnittene Kontrazeptionsberatung essenziell.
Clinical outcomes of surgical resection for recurrent lesion after curative esophagectomy for esophageal squamous cell carcinoma: a nationwide, large-scale retrospective study
Authors: Kudou Kensuke , Saeki Hiroshi , Nakashima Yuichiro , Kimura Yasue , Oki Eiji , Mori Masaki , Shimokawa Mototsugu , Kakeji Yoshihiro , Toh Yasushi , Doki Yuichiro , Matsubara Hisahiro 
Published: September 2021

Abstract
Background
Several studies have reported the efficacy of resection for recurrent lesions. However, they involved a limited number of subjects. This study aimed to identify a subset of patients who benefit from surgical resection of recurrent lesions after curative esophagectomy for esophageal squamous cell carcinoma.

Methods
Clinicopathological features of 186 patients with esophageal squamous cell carcinoma who underwent surgical treatment for postoperative recurrent lesions at 37 accredited institutions of the Japanese Esophageal Society were evaluated.

Results
The most common recurrence site was the lymph node (106 cases; 58.6%), followed by the lung (40 cases; 22.1%). Univariate analyses revealed that pN 0–1 at esophagectomy (P = 0.0348), recurrence-free interval of ≥ 550 days (P = 0.0306), R0 resection (P < 0.0001), and absence of severe complications after resection for recurrent lesions (Clavien–Dindo grade < IIIa) (P = 0.0472) were associated with better overall survival after surgical resection. According to multivariate analyses, pN 0–1 (P = 0.0146), lung metastasis (P = 0.0274), recurrence-free interval after curative esophagectomy of ≥ 550 days (P = 0.0266), R0 resection (P = 0.0009), and absence of severe complications after resection for recurrent lesions (Clavien–Dindo grade < IIIa) (P = 0.0420) were independent predictive factors for better overall survival.

Conclusions
Surgical resection of recurrent esophageal squamous cell carcinoma lesions is a useful option, especially for cases involving lower pN stage, lung metastasis, long recurrence-free intervals after esophagectomy, and technically resectable lesions. Surgical risks should be minimized as much as possible.
Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2
Authors: Li Xiaoduan , Zhang Yi , Wang Xinjing , Lin Feikai , Cheng Xi , Wang Ziliang , Wang Xipeng 
Published: September 2021

Abstract
Purpose
Long non-coding RNAs (lncRNAs) play vital roles in tumor progression and resistance. Ovarian cancer (OC), a common gynecological cancer, is associated with poor prognosis as it can progress to peritoneal metastasis and develop resistance to chemotherapy. This study aimed to examine the role of lncRNAs in the development of chemotherapy resistance in OC.

Methods
The clinical samples were divided into chemotherapy-sensitive and chemotherapy-resistant groups based on the chemotherapy response at follow-up. The glycolysis levels in the two groups were analyzed using positron emission tomography/computed tomography (PET/CT) scanning and immunohistochemistry. GEO dataset analysis revealed the expression of CTSLP8 in chemotherapy-resistant patients with OC. Two pairs of normal and diamminodichloroplatinum (DDP)-resistant cells were transfected with CTSLP8 overexpression and knockdown constructs to examine the functions of CTSLP8 in the OC cells and elucidate the underlying mechanisms. The in vivo effect of CTSLP8 overexpression and knockdown on the chemotherapy response of tumors was examined using a mouse subcutaneous tumor model. The tissue chips were subjected to fluorescence in situ hybridization and immunohistochemical (IHC) staining to examine the correlation among CTSLP8 expression, DDP resistance, and prognosis in OC.

Results
The dataset analysis demonstrated that CTSLP8 was upregulated in chemotherapy-resistant tumor tissues. CTSLP8 promoted the proliferation and development of DDP resistance in the OC cells. Moreover, CTSLP8 promoted c-Myc expression by facilitating the binding of PKM2 to the promoter region of c-Myc, thereby upregulating glycolysis. The analysis of tissue chips revealed that the upregulation of CTSLP8 was associated with the development of DDP resistance and poor prognosis in patients with OC.

Conclusions
These findings indicate that CTSLP8 forms a complex with PKM2 to regulate c-Myc, and this action results in the upregulation of cellular glycolysis, consequently promoting OC progression and development of chemotherapy resistance.

Headlights
1. CTSLP8 was upregulated in the chemotherapy-resistant tumor tissues.
2. CTSLP8 promoted the proliferation and cisplatin resistance in the OC cells.
3. CTSLP8 promoted glycolysis by facilitating the binding of PKM2 to the promoter region of c-Myc.
4. Inhibition of CTSLP8 or the combination of c-Myc inhibitors with cisplatin were potential therapeutic strategies for chemotherapy-resistant of OC.
Towards a Validation Methodology for Macroeconomic Agent-Based Models
Authors: Tieleman Sebastiaan 
Published: September 2021

AbstractAgent-based models provide a promising new tool in macroeconomic research. Questions have been raised, however, regarding the validity of such models. A methodology of macroeconomic agent-based model (MABM) validation, that provides a deeper understanding of validation practices, is required. This paper takes steps towards such a methodology by connecting three elements. First, is a foundation of model validation in general. Second is a classification of models dependent on how the model is validated. An important distinction in this classification is the difference between mechanism and target validation. Third, is a framework that revolves around the relationship between the structure of models of complex systems with emergent properties and validation in practice. Important in this framework is to consider MABMs as modelling multiple non-trivial levels. Connecting these three elements provides us with a methodology of the validation of MABMs and allows us to come to the following conclusions regarding MABM validation. First, in MABMs, mechanisms at a lower level are distinct from, but provide input to higher levels of mechanisms. Since mechanisms at different levels are validated in different ways we can come to a specific characterization of MABMs within the model classification framework. Second, because the mechanisms of MABMs are validated in a direct way at the level of the agent, MABMs can be seen as a move towards a more realist approach to modelling compared to DSGE.
Antecedents of Deviant Behavior: Psychological and Non-Psychological Factors and Ethical Justifications
Authors: Di Carlo Emiliano 
Published: September 2021

Abstract
An integrative model of ethical justifications in organizations is proposed. The model recognizes the roles of psychological and non-psychological factors on the link between ethical theories and the ethical reasoning and, consequently, on the way operators justify themselves when accused of being against (or not favoring) the good of the company. This study wants to contribute to highlighting the benefits of the prevention of deviant behavior through a more profound comprehension of its antecedents. The analysis confirms the complexity of human beings, and the need for an integrated approach that leads to clarity and coherence among tools (e.g. mission, code of ethics, incentive system), people and among both people and tools. A central role is played by the dissemination of a culture that considers the firm as a real entity, with its own interest, that is separated from that of its stakeholders and which brings the purpose of the common good.
1H R1ρ relaxation dispersion experiments in aromatic side chains
Authors: Dreydoppel Matthias , Lichtenecker Roman J. , Akke Mikael , Weininger Ulrich 
Published: September 2021

AbstractAromatic side chains are attractive probes of protein dynamic, since they are often key residues in enzyme active sites and protein binding sites. Dynamic processes on microsecond to millisecond timescales can be studied by relaxation dispersion experiments that attenuate conformational exchange contributions to the transverse relaxation rate by varying the refocusing frequency of applied radio-frequency fields implemented as either CPMG pulse trains or continuous spin-lock periods. Here we present an aromatic 1H R1ρ relaxation dispersion experiment enabling studies of two to three times faster exchange processes than achievable by existing experiments for aromatic side chains. We show that site-specific isotope labeling schemes generating isolated 1H–13C spin pairs with vicinal 2H–12C moieties are necessary to avoid anomalous relaxation dispersion profiles caused by Hartmann–Hahn matching due to the 3JHH couplings and limited chemical shift differences among 1H spins in phenylalanine, tyrosine and the six-ring moiety of tryptophan. This labeling pattern is sufficient in that remote protons do not cause additional complications. We validated the approach by measuring ring-flip kinetics in the small protein GB1. The determined rate constants, kflip, agree well with previous results from 13C R1ρ relaxation dispersion experiments, and yield 1H chemical shift differences between the two sides of the ring in good agreement with values measured under slow-exchange conditions. The aromatic1H R1ρ relaxation dispersion experiment in combination with the site-selective 1H–13C/2H–12C labeling scheme enable measurement of exchange rates up to kex = 2kflip = 80,000 s–1, and serve as a useful complement to previously developed 13C-based methods.
Physicochemical properties and thermal behavior of nitrocellulose granules with eutectic mixtures of stabilizers
Authors: Cieślak Katarzyna , Gańczyk-Specjalska Katarzyna , Drożdżewska-Szymańska Katarzyna , Królikowska Marta , Jakubczak Marcin 
Published: September 2021

AbstractExaminations of two-component mixtures, namely: triphenylamine + centralite I (TPA + CI) and triphenylamine + akardite II (TPA + AkaII) were carried out using differential scanning calorimetry (DSC), which served to determine phase diagrams. Experimental data were described with NRTL model and eutectic points for both systems were determined. For TPA + CI system, they were equal to xEu,TPA = 0.2899, TEu = 62.9 °C, whereas for TPA + AkaII system they amounted to xEu,TPA = 0.7868, TEu = 117.5 °C. Granules contain mixtures of eutectic composition were obtained. The physicochemical and thermal properties of resultant single base granules were studied. The helium density of both granules was approx. 1.47 g cm−3, the average dynamic force amounted to 0.55–0.60 bar−1 s−1, and the calorific value ranged from 3060 to 3095 J g−1. Both granules should be chemically stable for 10 years of storage at 25 °C; they meet the requirements of STANAG 4582 standard. DSC analysis of decomposition processes was used to determine kinetic parameters and to adjust the chemical reaction model of nth order with autocatalysis (CnB). Reaction order ranged from 2.6 to 3.0, while the activation energy was similar (197–198 kJ mol−1). Based on examination of thermal properties, it was observed that both eutectic mixtures of stabilizers prevent the decomposition reaction more efficiently than the use of individual compounds as stabilizers.
Deuterium-depleted water stimulates GLUT4 translocation in the presence of insulin, which leads to decreased blood glucose concentration
Authors: Molnár Miklós , Horváth Katalin , Dankó Tamás , Somlyai Ildikó , Kovács Beáta Zs. , Somlyai Gábor 
Published: September 2021

AbstractDeuterium (D) is a stable isotope of hydrogen (H) with a mass number of 2. It is present in natural waters in the form of HDO, at a concentration of 16.8 mmol/L, equivalent to 150 ppm. In a phase II clinical study, deuterium depletion reduced fasting glucose concentration and insulin resistance. In this study, we tested the effect of subnormal D-concentration on glucose metabolism in a streptozotocin (STZ)-induced diabetic rat model. Animals were randomly distributed into nine groups to test the effect of D2O (in a range of 25–150 ppm) on glucose metabolism in diabetic animals with or without insulin treatment. Serum glucose, fructose amine-, HbA1c, insulin and urine glucose levels were monitored, respectively. After the 8-week treatment, membrane-associated GLUT4 fractions from the soleus muscle were estimated by Western blot technique. Our results indicate that, in the presence of insulin, deuterium depletion markedly reduced serum levels of glucose, -fructose amine, and –HbA1c, in a dose-dependent manner. The optimal concentration of deuterium was between 125 and 140 ppm. After a 4-week period of deuterium depletion, the highest membrane-associated GLUT4 content was detected at 125 ppm. These data suggest that deuterium depletion dose-dependently enhances the effect of insulin on GLUT4 translocation and potentiates glucose uptake in diabetic rats, which explains the lower serum glucose, -fructose amine, and –HbA1c concentrations. Based on our experimental data, deuterium-depleted water could be used to treat patients with metabolic syndrome (MS) by increasing insulin sensitivity. These experiments indicate that naturally occurring deuterium has an impact on metabolic regulations.
Explaining rule of rescue obligations in healthcare allocation: allowing the patient to tell the right kind of story about their life
Authors: Sinclair Sean 
Published: September 2021

AbstractI consider various principles which might explain our intuitive obligation to rescue people from imminent death at great cost, even when the same resources could produce more benefit elsewhere. Our obligation to rescue is commonly explained in terms of the identifiability of the rescuee, but I reject this account. Instead, I offer two considerations which may come into play. Firstly, I explain the seeming importance of identifiability in terms of an intuitive obligation to prioritise life-extending interventions for people who face a high risk of an early death, and I explain this in turn with a fair innings-style principle which prioritises life-extending interventions for people expected to die young. However, this account is incomplete. It does not explain why we would devote the same resources to rescuing miners stuck down a mine even if they are elderly. We are averse to letting people die suddenly, or separated from friends and family. And so, secondly, I give a new account that explains this in terms of narrative considerations. We value life stories that follow certain patterns, classic patterns which are reflected in many popular myths and stories. We are particularly averse to depriving people of the opportunity to follow some such pattern as they approach death. This means allowing them to sort out their affairs, say goodbyes to family and friends, review their life, or come to terms with death itself. Such activities carry a lot of meaning as ways of closing our life story in the right way. So, for someone who has not been given much notice of their death, an extra month is worth much more than for other patients. Finally, I review the UK National Health Service's end of life premium, which gives priority to patients with short life expectancy. I suggest it falls short in terms of such considerations. For example, the NHS defines its timings in terms of how long the patient can expect to live as at the time of the treatment decision, whereas the timings should be specified in terms of time from diagnosis.
A DNA test for high incidence of soft scald and soggy breakdown postharvest disorders in Malus domestica Borkh
Authors: Miller Baylee A. , Tillman John R. , Howard Nicholas P. , Kostick Sarah A. , Evans Kate M. , Luby James J. 
Published: September 2021

AbstractThe ‘Honeycrisp’ apple, an economically important cultivar and breeding parent, is prone to soft scald and soggy breakdown postharvest physiological disorders. Phenotypic evaluation of soft scald is time consuming and costly, making it an excellent target for DNA-informed breeding. The objective of this study was to develop a DNA test for a soft scald and soggy breakdown quantitative trait locus (QTL) on linkage group two (LG2) that was characterized in a previous study. ‘Honeycrisp’ is homozygous for the undesirable high disorder incidence haplotype (HDI) at this QTL. In this study, sixteen single nucleotide polymorphism markers were evaluated for their associations with the HDI haplotype in a set of 132 unique cultivars and important breeding parents. A DNA test was successfully developed utilizing KASP™ (Kompetitive Allele Specific PCR) chemistry to identify the number of HDI haplotypes in individuals. This test had a 100% accuracy for detecting homozygous unfavorable HDI individuals and has an expected 88% accuracy over all three haplotype copy groups across the evaluated germplasm. This DNA test is a promising tool for minimizing the chances of selecting individuals that exhibit high incidence of soft scald postharvest disorder in ‘Honeycrisp’-related germplasm.