bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved outcomes using unmanipulated haploidentical hematopoietic stem cells combined with third‐party umbilical cord blood transplantation for non‐malignant diseases in children: The experience of a single center
Authors: Tang Xiangfeng , Yu Zhang , Ping Liu , Lu Wei , Jing Yuanfang , Cao Xiuyan 
Published: March 2021

AbstractBackgroundUnmanipulated haploid HSCT for SAA has resulted in improved outcomes over recent years. However, studies related to unmanipulated haploid HSCs combined with tp‐UCB transplantation for other types of NMD are rare. Accordingly, we present the outcomes of 109 pediatric patients with life‐threatening NMD undergoing unmanipulated haploid HSCs combined with tp‐UCB transplantation.ProcedureWe retrospectively investigated 109 pediatric patients with life‐threatening NMD treated with unmanipulated haploid HSCs combined with tp‐UCB transplantation in a single center.ResultsThe median days of neutrophil and platelet engraftment were +13 and +22 days, respectively. None of the cases experienced PGF. The incidence rates for grade I‐II, III‐IV aGVHD and cGVHD were 44.9%, 24.8%, and 9.3%, respectively. The incidence rates of CMV and EBV viremia were 46.7% and 39.4%, respectively. The median follow‐up duration was 997 days. In total, 106 patients survived, including 104 cases with FFS and 2 cases with SGF. Three patients died. The 5‐year TRM, OS, and FFS were 2.8%, 97.2%, and 96.2%, respectively.ConclusionThe results of unmanipulated haploid HSCs combined with tp‐UCB in pediatric patients with life‐threatening NMD were promising. However, further research is now needed to determine specific factors that might influence the engraftment of HSCs.
The Western Wall Controversy
Authors: Sapir Gideon 
Published: March 2021

Abstract
Since 1988 a group of Jewish women in Israel, who later organized as the “Women of the Wall,” have been battling to realize what they see as their right to hold a public prayer service, while wearing prayer shawls and phylacteries and reading from a Torah scroll, in the women’s section of the Western Wall Plaza. Some of the Orthodox are fiercely opposed to the WoW and its project. This issue has reached the Israeli courts several times and has repeatedly engaged the political system. This article examines whether one of the two positions can draw on constitutional arguments that would justify a ruling in its favor.
The Value of Sacred Places
Authors: Seglow Jonathan 
Published: March 2021

Abstract
This article explores the neglected topic of the value of sacred places of various religions. The great value that adherents of these religions ascribe to these places cannot account for their public political value, given that the duty to treat such places with respect falls on all citizens, whatever their faith. The article considers and rejects three views regarding the value of sacred places: that they are protected by cultural rights, that damaging them would hurt the feelings of religious believers, and that they are the collective property of religious groups. It then considers the right to religious liberty, which has been argued in recent scholarship on religious accommodation to be best defended through the value of integrity and by honoring one’s religious commitments. Although integrity is too individualistic a concept to explain the value of sacred places directly, the way in which these places embody sacredness here on earth helps enable integrity by showing what one’s commitments are invested in. This view of the value of sacred places can account for the value of non-religious sacred places and for the duty to respect them all.
Time, Power, and Religion
Authors: Cesari Jocelyne 
Published: March 2021

Abstract
The main argument of this paper is that the sacred time and space of the nation has displaced the meaning of sacredness of the religious sites, and legitimized the national community. By comparing the Temple Mount and Ayodhya disputes, the paper exposes the tensions between two polarities, sacred/profane and religious/political, which helps explain the influence of national identities on the contested sacredness of religious sites. The competition over the Temple Mount is nested within a “thicker” context of conflicting political claims over Jerusalem and national territory between Jewish groups on one hand and between Jews and Muslims on the other. The Ayodhya disagreement is related to the political tensions between the dominant and the minority religions, which have turned the religious dispute over a holy site into a debate on the sacredness of the national community.
Radiofrequency ablation for selective fetal reduction in complicated Monochorionic twins; comparing the outcomes according to the indications
Authors: Rahimi-Sharbaf Fatemeh , Ghaemi Marjan , Nassr Ahmed A. , Shamshirsaz Alireza A. , Shirazi Mahboobeh 
Published: March 2021

Abstract
Background
To evaluate the perinatal outcomes in women with complicated monochorionic diamniotic twins who underwent selective reduction using radiofrequency ablation (RFA).

Methods
This retrospective study included patients with complicated monochorionic diamniotic twins between 16 to 28 weeks who underwent selective reduction using RFA.

Results
During the study period, 143 women with complicated monochorionic twins underwent RFA including 52 with selective fetal growth restriction (sFGR), 48 with twin to twin transfusion syndrome (TTTS), 33 with major fetal anomalies in one of the twins, and 10 with reversed arterial perfusion sequence (TRAP). The overall survival was 71.3% (102/143). The procedures were technically successful in achieving selective termination in all cases. The mean ± SD of gestational age at the time of the procedure was 21.0 ± 2.3 weeks. The mean ± SD of gestational age at delivery was 34.6 ± 3.3 weeks. The mean ± SD of overall procedure-to-delivery time was 12 ± 1.7 weeks. The pregnancy success rates among sFGR, TRAP, TTTS and anomaly groups were 82.7, 80, 73 and 60.7% respectively. There were no maternal complications.

Conclusion
Radiofrequency ablation for fetal reduction in complicated monochorionic twin pregnancies appears to be a reasonable option. The pregnancy success rate following RFA selective reduction was highest among sFGR and TRAP groups and lowest in the anomaly group.
Evaluation of an occipito-cervico fusion with a new implant design: a biomechanical study
Authors: Migliorini Filippo , Baroncini Alice , El Mansy Yasser , Quack Valentin , Prescher Andreas , Mischer Max , Greven Johannes , Tingart Markus , Eschweiler Jörg 
Published: March 2021

Abstract
Background
A novel implant for occipitocervical fusion consisting of a median plate with an additional hook inserting in the foramen magnum was tested. Aim of this study was to test the stability of a new implant for occipitocervical fusion against the already available and employed median plate implant without hook.

Material and method
36 rigid polyurethane foams occipital artificial bones were used. The two occipital implants, namely the occipital plate with hook (Group 1) and the one without hook (Group 2), were applied to the artificial occiput trough three occipital screws and ensured into the experimental setup trough a crossbar. The test parameters were set using the testing machine software as follows: (1) test speed: 10 mm/ min, with 25 mm/ min maximum; (2) preload: 5 N; (3) force switch-off threshold: 90% force drop from F_max. Failure force and path were recorded. Failure force is defined as the maximum reaction force under which failure occurs (F_max), while failure path is the travel path during which failure occurs (dL).

Results
Group 1 (plate with hook) showed a mean failure force of 459.3 ± 35.9 N and a mean failure path of 5.8 ± 0.3 mm Group 2 (plate without hook) showed a mean failure force of 323.9 ± 20.2 N and a mean failure path of 7.2 ± 0.4 mm. The Shapiro-Wilk test score was not significant (P >  0.1), assuming that data were normally distributed. Group 1 had a statistically significant greater F_max (+ 135.37; P >  0.0001) and less dL (− 1.52; P > 0.0001) compared to group 2.

Conclusions
Medial plates with foramen magnum hooks showed to be more stable that plates without a hook. These new implants may represent a new tool in OCJ fixation, but further studies are required to investigate their behavior in an anatomical setting.
Ideal cardiovascular health at age 5–6 years and cardiometabolic outcomes in preadolescence
Authors: Jaspers Faijer-Westerink Hester , Stavnsbo Mette , Hutten Barbara A. , Chinapaw Mai , Vrijkotte Tanja G. M. 
Published: March 2021

AbstractBackgroundThe American Heart Association (AHA) developed a definition of ideal cardiovascular health (ICH) based on the presence of both ideal health behaviours (diet, physical activity, weight status and smoking) and ideal health factors (glucose, total cholesterol and blood pressure levels). However, research of ICH in the paediatric population is scarce. We aimed to study ICH at age 5–6 years by extending the original ICH score with the health behaviours: sleep duration, screen time and prenatal smoke exposure, and to evaluate its association with cardiometabolic outcomes at age 11–12.MethodsA total of 1666 children aged 5–6 years were selected from the database of the ABCD-study, a prospective cohort study on the health and development of children born in Amsterdam, the Netherlands. Of these, 846 (50.8%) were boys and 1460 (87.6%) had a healthy weight. Data on self-reported health behaviours and health factors were used to calculate the ICH scores (original and extended) by adding the frequency of scoring ‘healthy’ on each indicator, based on international cut-offs. The children were followed up for 6 years and cardiometabolic outcomes (carotid intima-media thickness (CIMT), blood pressure, glucose and lipids) were measured. Associations between ICH (both original and extended) and cardiometabolic outcomes were examined using multivariable regression models.ResultsAt age 5–6 years, 11% scored poor (score 1–5), 56% intermediate (score 6–7) and 33% good (score 8–9) on extended ICH. Healthy diet and normal total cholesterol concentrations were the least prevalent. Neither the original nor the extended ICH scores were associated with CIMT at age 11–12. A higher score on the extended ICH was associated with lower total cholesterol (pfor trend < 0.001), lower systolic (pfor trend = 0.012) and diastolic blood pressure (pfor trend = 0.011), and lower body mass index (BMI) (p < 0.001) at age 11–12. The original ICH score was associated with lower total cholesterol (p < 0.001) and BMI (p < 0.001) only.ConclusionOur findings suggest that extending the ICH score in young children with additional health behaviours improves prediction of some cardiometabolic outcomes, but not CIMT in preadolescence, compared to the original ICH score. We would recommend other researchers to incorporate objective measures of health behaviours and longer follow-up to find out whether associations persist into adulthood.
Rosaceae, Brassicaceae and pollen beetles: exploring relationships and evolution in an anthophilous beetle lineage (Nitidulidae, Meligethes-complex of genera) using an integrative approach
Authors: Liu Meike , Huang Min , Cline Andrew Richard , Mancini Emiliano , Scaramuzzi Andrea , Paradisi Simone , Audisio Paolo , Badano Davide , Sabatelli Simone 
Published: March 2021

Abstract
Background
Meligethes are pollen-beetles associated with flowers of Rosaceae as larvae. This genus currently consists of 63 known species in two subgenera, Meligethes and Odonthogethes, predominantly occurring in the eastern Palaearctic. We analyzed 74 morphological and ecological characters (169 states) of all species, as well as of 11 outgroup species from 7 Meligethinae genera (including Brassicogethes), to investigate their phylogeny. We also conducted a parallel molecular analysis on 9 Meligethes, 9 Odonthogethes, 3 Brassicogethes and 2 Meligethinus species based on DNA sequence data from mitochondrial (COI, 16S) and nuclear (CAD) genes.

Results
Morphological phylogenetic reconstructions supported the monophyly of the whole genus and clades corresponding to purported subgenera Meligethes s.str. and Odonthogethes. Main species-groups were mostly confirmed, however some unresolved polytomies remained. Molecular data placed members of Brassicogethes (including 42 mostly W Palearctic species associated with Brassicaceae) as sister to Odonthogethes, with this clade being sister to Meligethes s.str. This phylogenetic scenario suggests that monophyletic Meligethes s.str., Odonthogethes and Brassicogethes should be regarded alternatively as three subgenera of a monophyletic Meligethes, or three genera in a monophyletic genus-complex, with mutually monophyletic Brassicogethes and Odonthogethes. Molecular analyses estimated the origin of this lineage at ca. 14–15 Mya from a common stem including Meligethinus.

Conclusions
We hypothesize that the ancestor of Meligethes specialized on Rosaceae in the Middle Miocene (likely in Langhian Age) and subsequently radiated during Late Miocene and Plio-Pleistocene maintaining a trophic niche on this plant family. This radiation was primarily due to geographic isolation in E Asiatic mountain systems. Combined evidence from morphology, ancestral state parsimony reconstruction of host-plant associations and molecular evidence suggested that Rosoideae (Rosa spp.) represented the ancestral hosts of Meligethes s.str., followed by an independent shift of ancestral Odonthogethes (ca. 9–15 Mya) on Rubus (Rosoideae) and members of Rosaceae Spiraeoideae. Other ancestral Odonthogethes probably shifted again on the unrelated plant family Brassicaceae (maybe 8–14 Mya in S China), allowing a rapid westward radiation of the Brassicogethes clade.
A survey of International Health Regulations National Focal Points experiences in carrying out their functions
Authors: Packer Corinne , Halabi Sam F. , Hollmeyer Helge , Mithani Salima S. , Wilson Lindsay , Ruckert Arne , Labonté Ronald , Fidler David P. , Gostin Lawrence O. , Wilson Kumanan 
Published: March 2021

AbstractBackgroundThe 2005 International Health Regulations (IHR (2005)) require States Parties to establish National Focal Points (NFPs) responsible for notifying the World Health Organization (WHO) of potential events that might constitute public health emergencies of international concern (PHEICs), such as outbreaks of novel infectious diseases. Given the critical role of NFPs in the global surveillance and response system supported by the IHR, we sought to assess their experiences in carrying out their functions.MethodsIn collaboration with WHO officials, we administered a voluntary online survey to all 196 States Parties to the IHR (2005) in Africa, Asia, Europe, and South and North America, from October to November 2019. The survey was available in six languages via a secure internet-based system.ResultsIn total, 121 NFP representatives answered the 56-question survey; 105 in full, and an additional 16 in part, resulting in a response rate of 62% (121 responses to 196 invitations to participate). The majority of NFPs knew how to notify the WHO of a potential PHEIC, and believed they have the content expertise to carry out their functions. Respondents found training workshops organized by WHO Regional Offices helpful on how to report PHEICs. NFPs experienced challenges in four critical areas: 1) insufficient intersectoral collaboration within their countries, including limited access to, or a lack of cooperation from, key relevant ministries; 2) inadequate communications, such as deficient information technology systems in place to carry out their functions in a timely fashion; 3) lack of authority to report potential PHEICs; and 4) inadequacies in some resources made available by the WHO, including a key tool – the NFP Guide. Finally, many NFP representatives expressed concern about how WHO uses the information they receive from NFPs.ConclusionOur study, conducted just prior to the COVID-19 pandemic, illustrates key challenges experienced by NFPs that can affect States Parties and WHO performance when outbreaks occur. In order for NFPs to be able to rapidly and successfully communicate potential PHEICs such as COVID-19 in the future, continued measures need to be taken by both WHO and States Parties to ensure NFPs have the necessary authority, capacity, training, and resources to effectively carry out their functions as described in the IHR.
Parent–child-agreement on health-related quality of life and its determinants in patients born with Esophageal Atresia: a Swedish–German cross-sectional study
Authors: Witt Stefanie , Dellenmark-Blom Michaela , Kuckuck Susanne , Dingemann Jens , Abrahamsson Kate , Dingemann Carmen , Chaplin John Eric , Ure Benno , Bullinger Monika , Gatzinsky Vladimir , Jönsson Linus , Quitmann Julia Hannah 
Published: March 2021

Abstract
Background
The aim was to compare parent and child-reported health-related quality of life (HRQOL) of children born with esophageal atresia (EA) and determine factors that affect the level of parent–child agreement.

Methods
We included 63 parent–child dyads of children born with EA aged 8–18 from Germany and Sweden. The generic PedsQL 4.0™ questionnaire and the condition-specific EA QOL questionnaire were used to assess children’s HRQOL from parents' and children’s perspectives. The PedsQL™ Family Impact Module was used to assess parental HRQOL and Family Functioning.

Results
On an individual level, intra-class correlation coefficients indicated strong levels of parent–child agreement (.61–.97). At the group level, the analyses showed no significant differences between the responses of parents and children. When a disagreement occurred, parents were more likely to rate generic HRQOL lower than the children (19–35%) and condition-specific HRQOL higher than the children (17–33%). Findings of the binary logistic regression analyzes showed that the child’s age, gender, and country (Germany vs. Sweden) were significant predictors of parent–child agreement in condition-specific HRQOL. We did not identify any significant variables that explain agreement for the generic HRQOL.

Conclusion
The parent–child agreement is mostly good, suggesting that parent-reports are a reliable source of information. However, discrepancies may occur and can be explained by the child's age, gender, and country (Sweden vs. Germany). Both perspectives are essential sources for treating EA patients and should not be considered right or wrong. Instead, this information broadens the perspective on pediatric EA patients.
Construction autophagy-related prognostic risk signature to facilitate survival prediction, individual treatment and biomarker excavation of epithelial ovarian cancer patients
Authors: Fei Hongjun , Chen Songchang , Xu Chenming 
Published: March 2021

Abstract
Background
Existing clinical methods for prognosis evaluating for Epithelial Ovarian Cancer (EOC) patients had defects of invasive, unsystematic and subjective and little data are available for individualizing treatment, therefore, to identify potential prognostic markers and new therapeutic targets for EOC is urgently required.

Results
Expression of 232 autophagy-related genes (ARGs) in 354 EOC and 56 human ovarian surface epithelial specimens from 7 independent laboratories were analyzed, 31 mRNAs were identified as DEARGs. We did functional and pathway enrichment analysis and constructed protein–protein interaction network for all DEARGs. To screen out candidate DEARGs related to EOC patients’ survival and construct an autophagy-related prognostic risk signature, univariate and multivariate Cox proportional hazards models were established separately. Finally, 5 optimal independent prognostic DEARGs (PEX3, DNAJB9, RB1, HSP90AB1 and CXCR4) were confirmed and the autophagy-related risk model was established by the 5 prognostic DEARGs. The accuracy and robustness of the prognostic risk model for survival prediction were evaluated and verified by analyzing the correlation between EOC patients’ survival status, clinicopathological features and risk scores.

Conclusions
The autophagy-related prognostic risk model can be independently used to predict overall survival in EOC patients, it can also potentially assist in individualizing treatment and biomarker development.
Spontaneous resolution of atopic dermatitis incidental to participation in benralizumab clinical trial for severe, uncontrolled asthma: a case report
Authors: Pham David N. 
Published: March 2021

Abstract
Background
T cell-mediated eosinophilia is associated with numerous conditions—including atopic dermatitis, food allergies, and asthma—collectively known as the “atopic march.” Benralizumab is a recombinant, humanized, afucosylated monoclonal antibody directed against the ⍺ chain of the eosinophil cell surface receptor IL-5R. Benralizumab treatment causes near-complete depletion of circulating eosinophils and was approved in 2017 for add-on, maintenance treatment of severe asthma with an eosinophilic phenotype, based on the results of the CALIMA and SIROCCO pivotal trials. Benralizumab is not currently approved for the treatment of eosinophilic conditions besides asthma; however, during the CALIMA trial, spontaneous resolution of atopic dermatitis was observed in a patient, concurrent with reduction in her asthma symptoms.

Case presentation
In January 2015, a 14-year-old Asian girl with severe, uncontrolled asthma was enrolled in CALIMA. The patient’s baseline eosinophil blood count was 1200 cells/μL, her pre-bronchodilator forced expiratory volume in 1 second (FEV1) was 1.9 L and FEV1/forced vital capacity (FVC) ratio was 71.4%, and her post-bronchodilator FEV1 was 3.2 L (FEV1/FVC of 115.9%). Her overall baseline asthma symptom score was 3.9 and her asthma exacerbation rate in the prior year was 4. She also displayed a pronounced, pruritic, chronic, inflammatory rash consistent with atopic dermatitis across her face. The investigator was blinded to the patient’s treatment group during treatment; however, her asthma symptoms diminished over the course of the study (FEV1 at 56 weeks, 3.01 L/110.5% (pre) and 3.25 L/119.3% (post); overall asthma symptom score 2.1; one influenza-associated exacerbation). Furthermore, her atopic dermatitis symptoms resolved spontaneously within the first 5 months of the study. After unblinding, the patient was confirmed to have been randomized to an active treatment arm, and her blood eosinophil count had dropped below the limit of detection after the first study dose.

Conclusions
Given the potential shared mechanisms between eosinophilic asthma and atopic dermatitis, it is plausible that benralizumab-induced eosinopenia factored into the resolution of the patient’s atopic dermatitis. Further clinical studies are warranted to determine whether benralizumab or other drugs targeted against IL-5/IL-5R may be useful in managing multiple conditions associated with eosinophilia.
Complete convergence for weighted sums of widely orthant-dependent random variables
Authors: Chen Pingyan , Sung Soo Hak 
Published: March 2021

AbstractThe complete convergence results for weighted sums of widely orthant-dependent random variables are obtained. A strong law of large numbers for weighted sums of widely orthant-dependent random variables is also obtained. Our results extend and generalize some results of Chen and Sung (J. Inequal. Appl. 2018:121, 2018), Zhang et al. (J. Math. Inequal. 12:1063–1074, 2018), Chen and Sung (Stat. Probab. Lett. 154:108544, 2019), Lang et al. (Rev. Mat. Complut., 2020, 10.1007/s13163-020-00369-5), and Liang (Stat. Probab. Lett. 48:317–325, 2000).