bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kemampuan Berpikir Kreatif Matematis dan Resiliensi Matematis
Authors: Sari Rizki Agustina , Untarti Reni 
Published: June 2021

AbstractMathematical creative thinking ability is a critical ability in learning mathematics, especially in solving mathematical problems. This research is a qualitative descriptive study that aims to describe the mathematical creative thinking skills based on the mathematical resilience of grade VII F students of SMP Negeri 1 Banyumas. The research subjects were grouped into 3 categories, namely high, medium, and low mathematical resilience categories. The sampling technique used purposive sampling by taking 3 people each in each category to become respondents. Data collection was done by giving questionnaires, written tests, interviews, and documentation which were carried out online. The data analysis technique was done by reducing the data, presenting the data, and drawing conclusions. The results showed: (1) students in the high mathematical resilience category were able to provide a variety of different solutions, as well as come up with new ideas with systematic and detailed answers, (2) students in the moderate mathematical resilience category were able to provide more than one different solution with systematic answers but not detailed, and (3) students in the low mathematical resilience category can solve mathematical problems with systematic.Keywords: Mathematical Creative Thinking Skills; Mathematical ResilienceÃÂ AbstrakKemampuan berpikir kreatif matematis adalah kemampuan yang penting dalam pembelajaran matematika, terlebih dalam penyelesaian permasalahan matematika. Penelitian ini merupakan penelitian deskriptif kualitatif yang bertujuan untuk mendeskripsikan kemampuan berpikir kreatif matematis berdasarkan pada resiliensi matematis siswa kelas VII F SMP Negeri 1 Banyumas. Subyek penelitian dikelompokkan menjadi 3 kategori, yaitu kategori resiliensi matematis tinggi, sedang, dan rendah. Teknik pengambilan sampel menggunakan purposive sampling dengan mengambil masing Ã¢â¬âmasing 3 orang pada setiap kategori untuk dijadikan responden. Pengumpulan data dilakukan dengan pemberian angket, tes tertulis, wawancara, dan dokumentasi yang dilakukan secara online. Teknik analisis data dilakukan dengan reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan: (1) siswa kategori resiliensi matematis tinggi mampu memberikan berbagai penyelesaian berbeda, serta memunculkan ide baru dengan jawaban yang sistematis dan terperinci, (2) siswa kategori resiliensi matematis sedang mampu memberikan lebih dari satu penyelesaian yang berbeda dengan jawaban yang sistematis namun tidak rinci, dan (3) siswa kategori resiliensi matematis rendah mampu menyelesaikan permasalahan matematika dengan jawaban yang sistematis.Kata Kunci: Kemampuan Berpikir Kreatif Matematis; Resiliensi Matematis
Ion transporters and their molecular regulation mechanism in plants
Authors: Walid Saibi , Faiçal Brini 
Published: June 2021

With the global population predicted to grow by at least 25% by 2050, the need for sustainable production of nutritious foods is important for human and environmental health. Recent progress demonstrate that membrane transporters can be used to improve yields of staple crops, increase nutrient content and resistance to key stresses, including salinity, which in turn could expand available arable land. Exposure to salt stress affects plant water relations and creates ionic stress in the form of the cellular accumulation of Na+ and Cl- ions. However, salt stress also impacts heavily on the homeostasis of other ions such as Ca2+, K+, and NO3- and therefore requires insights into how transport and compartmentation of these nutrients are altered during salinity stress. Since Na+ interferes with K+ homeostasis, maintaining a balanced cytosolic Na+/K+ ratio has become a key salinity tolerance mechanism. Achieving this homeostatic balance requires the activity of Na+ and K+ transporters and/or channels. The aim of this review is to seek answers to this question by examining the role of major ions transporters and channels in ions uptake, translocation and intracellular homeostasis in plants.
THE INFLUENCE OF ORGANIZATIONAL CULTURE AND PERCEIVED ORGANIZATIONAL SUPPORT ON EMPLOYEE ENGAGEMENT WITH ORGANIZATIONAL COMMITMENT AS A MEDIATOR
Authors: Amanda Hanna , Soeling Pantius Drahen 
Published: June 2021

The focus of this research is how to improve employee engagement at the PT.X head office by examining the relationship between organizational culture and organizational perceptions of employee engagement with organizational commitment as a mediator. This research uses quantitative approach, which is a study that aims to explain a cause of the occurrence of social phenomena, which the phenomenon will be explained by conducting an objective measurement. Primary data collection through the dissemination of questionnaires to 74 respondents. Data analysis using the partial least square equation model or can be known as SEM-PLS. Based on the results of research that has been found, it can be concluded that organizational culture variable does not give a significant direct positive influence on employee engagement, whereas when viewed on variables perceived organizational support and organizational commitment, these two variables have a significant positive direct affect on employee engagement. If the direct influence relationship between organizational culture and employee engagement does not have a significant influence, but when the variable is mediated by organizational commitment, then the results state that there is a significant positive influence relationship between the two variables. This shows that the organization's commitment to succeed has a significant role in mediating the relationship between organizational culture and employee engagement.
Dampak Kecanduan Smartphone Terhadap Kualitas Tidur Siswa SMP
Authors: Supartini Yupi , Martiana Puput Dwi , Sulastri Titi 
Published: June 2021

Excessive smartphone use has a higher risk of sleep disturbances and affects a person’s sleep quality. The purpose of this research is to determine the relationship between respondent’s characteristics and smartphone addiction to the sleep quality of adolescents at Budi Cendikia Islamic School Depok. This type of research is quantitative with a descriptive analytic approach and a cross sectional research design. The population is all 359 students. Sampling in this study using stratified random sampling technique with 112 respondents. The SAS-SV questionnaire was used to measure the level of smartphone addiction, while the PSQI questionnaire was used to measure sleep quality in adolescents. The statistical test used Chi Square and Mann Whitney with a significance level of α = 0.05. The results of the univariate statistical test showed that most of the respondents were male (52.7%), 13 years old (35.7%), had a high rate of smartphone addiction (61.6%), and poor sleep quality (70.5%). Meanwhile, the results of the bivariate statistical test showed that there was a significant difference between gender (p = 0.020) and smartphone addiction (p = 0.007) with sleep quality, but there was no significant difference between age and sleep quality (p = 0.938). This study concludes that there is a relationship between gender and smartphone addiction on students' sleep quality, but there is no relationship between age and sleep quality of students. Hence, it is necessary to limit the use of smartphones so that smartphone addiction can be minimized and sleep quality is good.”
Creativity and attitudes in English language learning
Authors: Ruiz Ortega Rosario de los Milagros 
Published: June 2021

Una de las competencias más importantes en bachillerato es el desarrollo de las habilidades de escritura; por eso, es indispensable promover estrategias de aprendizaje gramatical de forma situada que doten a los estudiantes de conocimientos explícitos sobre la lengua para comunicar sus ideas eficazmente. Para ello, el texto literario es un recurso valioso que fortalece la competencia lingüística a través de la creación poética. Aquí se ofrece una propuesta didáctica, cuyo soporte es la estructura analógica; en ella se combinan las funciones poética y metalingüística de la lengua, por medio de la producción de greguerías, para analizar cuál es la función del verbo. De esta manera, al reconocer el tipo de sintagma verbal escrito, se confirma si la intención comunicativa ha sido expresada correctamente.
Abstract
This in an exploratory research about students’ attitudes towards English language learning and teaching creativity at the Universidad Autónoma del Estado de Hidalgo (UAEH). The participants were learners in the first and last English course, which is the sixth semester. The purpose was to find out what kind of tendencies the results exhibit as students advance in studies, and to what extent teachers’ creativity might have influenced the outcome. Data was collected from 297 students currently enrolled in the Instituto de Ciencias Sociales y Humanidades (ICSHU), using a questionnaire and focus group interviews. Results showed that attitudes to English language learning are extremely positive among basic level students, but negative feelings increase in the last course. Regarding creativity, it was found that teachers are too enclosed by the school policies that they do not perform at their fullest potential creativity.
Periostin/Filamin-A: A Candidate Central Regulatory Axis for Valve Fibrogenesis and Matrix Compaction
Authors: Misra Suniti , Ghatak Shibnath , Moreno-Rodriguez Ricardo A. , Norris Russell A. , Hascall Vincent C. , Markwald Roger R. 
Published: June 2021

BackgroundDiscoveries in the identification of transcription factors, growth factors and extracellular signaling molecules have led to the detection of downstream targets that modulate valvular tissue organization that occurs during development, aging, or disease. Among these, matricellular protein, periostin, and cytoskeletal protein filamin A are highly expressed in developing heart valves. The phenotype of periostin null indicates that periostin promotes migration, survival, and differentiation of valve interstitial cushion cells into fibroblastic lineages necessary for postnatal valve remodeling/maturation. Genetically inhibiting filamin A expression in valve interstitial cushion cells mirrored the phenotype of periostin nulls, suggesting a molecular interaction between these two proteins resulted in poorly remodeled valve leaflets that might be prone to myxomatous over time. We examined whether filamin A has a cross-talk with periostin/signaling that promotes remodeling of postnatal heart valves into mature leaflets.ResultsWe have previously shown that periostin/integrin-β1 regulates Pak1 activation; here, we revealed that the strong interaction between Pak1 and filamin A proteins was only observed after stimulation of VICs with periostin; suggesting that periostin/integrin-β-mediated interaction between FLNA and Pak1 may have a functional role in vivo. We found that FLNA phosphorylation (S2152) is activated by Pak1, and this interaction was observed after stimulation with periostin/integrin-β1/Cdc42/Rac1 signaling; consequently, FLNA binding to Pak1 stimulates its kinase activity. Patients with floppy and/or prolapsed mitral valves, when genetically screened, were found to have point mutations in the filamin A gene at P637Q and G288R. Expression of either of these filamin A mutants failed to increase the magnitude of filamin A (S2152) expression, Pak1-kinase activity, actin polymerization, and differentiation of VICs into mature mitral valve leaflets in response to periostin signaling.ConclusionPN-stimulated bidirectional interaction between activated FLNA and Pak1 is essential for actin cytoskeletal reorganization and the differentiation of immature VICs into mature valve leaflets.
A Single Dose of Nitrate Increases Resilience Against Acidification Derived From Sugar Fermentation by the Oral Microbiome
Authors: Rosier Bob T. , Palazón Carlos , García-Esteban Sandra , Artacho Alejandro , Galiana Antonio , Mira Alex 
Published: June 2021

Tooth decay starts with enamel demineralization due to an acidic pH, which arises from sugar fermentation by acidogenic oral bacteria. Previous in vitro work has demonstrated that nitrate limits acidification when incubating complex oral communities with sugar for short periods (e.g., 1-5 h), driven by changes in the microbiota metabolism and/or composition. To test whether a single dose of nitrate can reduce acidification derived from sugar fermentation in vivo, 12 individuals received a nitrate-rich beetroot supplement, which was compared to a placebo in a blinded crossover setting. Sucrose-rinses were performed at baseline and 2 h after supplement or placebo intake, and the salivary pH, nitrate, nitrite, ammonium and lactate were measured. After nitrate supplement intake, the sucrose-induced salivary pH drop was attenuated when compared with the placebo (p &lt; 0.05). Salivary nitrate negatively correlated with lactate production and positively with ΔpH after sucrose exposure (r= -0.508 and 0.436, respectively, both p &lt; 0.05). Two additional pilot studies were performed to test the effect of sucrose rinses 1 h (n = 6) and 4 h (n = 6) after nitrate supplement intake. In the 4 h study, nitrate intake was compared with water intake and bacterial profiles were analysed using 16S rRNA gene Illumina sequencing and qPCR detection of Rothia. Sucrose rinses caused a significant pH drop (p &lt; 0.05), except 1 h and 4 h after nitrate supplement intake. After 4 h of nitrate intake, there was less lactate produced compared to water intake (p &lt; 0.05) and one genus; Rothia, increased in abundance. This small but significant increase was confirmed by qPCR (p &lt; 0.05). The relative abundance of Rothia and Neisseria negatively correlated with lactate production (r = -0.601 and -0.669, respectively) and Neisseria positively correlated with pH following sucrose intake (r = 0.669, all p &lt; 0.05). Together, these results show that nitrate can acutely limit acidification when sugars are fermented, which appears to result from lactate usage by nitrate-reducing bacteria. Future studies should assess the longitudinal impact of daily nitrate-rich vegetable or supplement intake on dental health.
Upregulation of LIMK1 Is Correlated With Poor Prognosis and Immune Infiltrates in Lung Adenocarcinoma
Authors: Lu Guojun , Zhou Ying , Zhang Chenxi , Zhang Yu 
Published: June 2021

BackgroundProtein-coding gene LIM Domain Kinase 1 (LIMK1) is upregulated in various tumors and reported to promote tumor invasion and metastasis. However, the prognostic values of LIMK1 and correlation with immune infiltrates in lung adenocarcinoma are still not understood. Therefore, we evaluated the prognostic role of LIMK1 and its correlation with immune infiltrates in lung adenocarcinoma.MethodsTranscriptional expression profiles of LIMK1 between lung adenocarcinoma tissues and normal tissues were downloaded from the Cancer Genome Atlas (TCGA). The LIMK1 protein expression was assessed by the Clinical Proteomic Tumor Analysis Consortium (CPTAC) and the Human Protein Atlas. Receiver operating characteristic (ROC) curve was used to differentiate lung adenocarcinoma from adjacent normal tissues. Kaplan-Meier method was conducted to assess the effect of LIMK1 on survival. Protein-protein interaction (PPI) networks were constructed by the STRING. Functional enrichment analyses were performed using the “ClusterProfiler” package. The relationship between LIMK1 mRNA expression and immune infiltrates was determined by tumor immune estimation resource (TIMER) and tumor-immune system interaction database (TISIDB).ResultsThe expression of LIMK1 in lung adenocarcinoma tissues was significantly upregulated than those in adjacent normal tissues. Increased LIMK1 mRNA expression was associated with lymph node metastases and high TNM stage. The ROC curve analysis showed that with a cutoff level of 4.908, the accuracy, sensitivity, and specificity for LIMK1 differentiate lung adenocarcinoma from adjacent controls were 69.5, 93.2, and 71.9%, respectively. Kaplan-Meier survival analysis showed lung adenocarcinoma patients with high- LIMK1 had a worse prognosis than those with low- LIMK1 (43.1 vs. 55.1 months, P = 0.028). Correlation analysis indicated LIMK1 mRNA expression was correlated with tumor purity and immune infiltrates.ConclusionUpregulated LIMK1 is significantly correlated with poor survival and immune infiltrates in lung adenocarcinoma. Our study suggests that LIMK1 can be used as a biomarker of poor prognosis and potential immune therapy target in lung adenocarcinoma.
A Novel Controlled PTEN-Knockout Mouse Model for Prostate Cancer Study
Authors: Liu Sen , Zhang Bing , Rowan Brian G. , Jazwinski S. Michal , Abdel-Mageed Asim B. , Steele Chad , Wang Alun R. , Sartor Oliver , Niu Tianhua , Zhang Qiuyang 
Published: June 2021

Prostate cancer (PCa) is associated with advanced age, but how age contributes to prostate carcinogenesis remains unknown. The prostate-specific Pten conditional knockout mouse model closely imitates human PCa initiation and progression. To better understand how age impacts PCa in an experimental model, we have generated a spatially and temporally controlled Pten-null PCa murine model at different ages (aged vs. non-aged) of adult mice. Here, we present a protocol to inject the Cre-expressing adenovirus with luciferin tag, intraductally, into the prostate anterior lobes of Pten-floxed mice; Pten-loss will be triggered post-Cre expression at different ages. In vivo imaging of luciferin signal following viral infection confirmed successful delivery of the virus and Cre activity. Immunohistochemical staining confirmed prostate epithelial-specific expression of Cre recombinase and the loss of Pten and activation of P-Akt, P-S6, and P-4E-BP1. The Cre-expression, Pten ablation, and activated PI3K/AKT/mTOR pathways were limited to the prostate epithelium. All mice developed prostatic epithelial hyperplasia within 4 weeks after Pten ablation and prostatic intraepithelial neoplasia (PIN) within 8 weeks post-Pten ablation. Some PINs had progressed to invasive adenocarcinoma at 8–16 weeks post-Pten ablation. Aged mice exhibited significantly accelerated PI3K/AKT/mTOR signaling and increased PCa onset and progression compared to young mice. The viral infection success rate is ∼80%. This model will be beneficial for investigations of cancer-related to aging.
Intravenous Thrombolysis After Dabigatran Reversal by Idarucizumab: A Systematic Review of the Literature
Authors: Frol Senta , Sagris Dimitrios , Pretnar Oblak Janja , Šabovič Mišo , Ntaios George 
Published: June 2021

Background and Purpose: Idarucizumab achieves instant reversal of anticoagulation and enables intravenous thrombolysis (IVT) in dabigatran-treated acute ischemic stroke (AIS) patients. AIS in dabigatran-treated patients is a rare event, therefore the experience is limited. A review of all published cases was performed to evaluate the safety and effectiveness of this therapeutic strategy.Methods: We searched PubMed and Scopus for all published cases of IVT after reversal with idarucizumab in dabigatran-treated AIS patients. The outcomes were safety assessed by hemorhagic transformation (HT), symptomatic intracranial hemorrhage (SICH) and death, and efficacy assessed by National Institutes of Health Stroke Scale (NIHSS) reduction.Results: We identified 251 AIS patients (39,9% females) with an average age of 74 years. HT, SICH, and death were reported in 19 (7.6%), 9 (3.6%), and 21 (8.4%) patients, respectively. Patients experiencing HT presented with more severe strokes (median NIHSS on admission: 21 vs. 8, p &lt; 0.001; OR: 1.12, 95% CI: 1.05–1.20). After IVT there was a significant NIHSS reduction of 6 points (IQR:3–10, p &lt; 0.001) post-stroke and linear regression revealed a correlation of admission NIHSS to NIHSS reduction (p &lt; 0.001).Conclusions: In this systematic review of all published cases of IVT in dabigatran-treated AIS patients after reversal with idarucizumab the rates of HT, SICH and mortality, as well as NIHSS reduction, were comparable with previous studies in non-anticoagulated patients. This provides reassuring evidence about the safety and efficacy of this therapeutic strategy.
Ketogenic Diet in the Treatment of Super-Refractory Status Epilepticus at a Pediatric Intensive Care Unit: A Single-Center Experience
Authors: Breu Markus , Häfele Chiara , Glatter Sarah , Trimmel-Schwahofer Petra , Golej Johann , Male Christoph , Feucht Martha , Dressler Anastasia 
Published: June 2021

Background: To evaluate the use of the ketogenic diet (KD) for treatment of super-refractory status epilepticus (SRSE) at a pediatric intensive care unit (PICU).Design: A retrospective analysis of all pediatric patients treated for SRSE with the KD at our center was performed using patient data from our prospective longitudinal KD database.Setting: SRSE is defined as refractory SE that continues or recurs 24 h or more after initiation of anesthetic drugs. We describe the clinical and electroencephalographic (EEG) findings of all children treated with KD at our PICU. The KD was administered as add-on after failure of standard treatment. Response was defined as EEG seizure resolution (absence of seizures and suppression–burst ratio ≥50%).Patients: Eight consecutive SRSE patients (four females) treated with KD were included. Median age at onset of SRSE was 13.6 months (IQR 0.9–105), and median age at KD initiation was 13.7 months (IQR 1.9 months to 8.9 years). Etiology was known in 6/8 (75%): genetic in 4 (50%), structural in 1 (12.5%), and autoimmune/inflammatory in 1 (12.5%).Main Results: Time from onset of SRSE to initiation of KD was median 6 days (IQR 1.3–9). Time until clinically relevant ketosis (beta-hydroxybutyrate (BHB) &gt;2 mmol/L in serum) was median 68.0 h (IQR 27.3–220.5). Higher ketosis was achieved when a higher proportion of enteral feeds was possible. Four (50%) patients responded to KD treatment within 7 days. During follow-up (median 4.2 months, IQR 1.6–12.3), 5/8 patients—three of them responders—died within 3–12 months after SRSE.Conclusions: In eight patients with SRSE due to severe etiologies including Alpers syndrome, we report an initial 50% response to KD. KD was used early in SRSE and sufficient levels of ketosis were reached early in most patients. Higher ketosis was achieved with combined enteral and parenteral feedings.