bluuebunny/crossref_metadata_2025_split huggingface dataset:
SINTESIS DAN KARAKTERISASI KOMPOSIT ZEOLIT MAGNETIT DAN APLIKASINYA SEBAGAI ADSORBEN Ni(II)
Authors: Rosyidah Anis Kholifatur , Suyanta Suyanta 
Published: January 2021

Sintesis, karakterisasi dan uji adsorpsi komposit zeolit magnetit telah dilakukan. Komposit zeolit magnetit disintesis menggunakan metode kopresipitasi campuran Fe2+ dan Fe3+ pada pH 11 dengan mempelajari pengaruh durasi pengadukan reaktan terhadap kristalinitas produk. Hasil sintesis dikarakterisasi dengan metode spektrofotometri Inframerah (FTIR) dan difraksi sinar-X (XRD). Aplikasi zeolit-magnetit sebagai adsorben Ni(II) dipelajari dengan mengkaji pengaruh variasi waktu adsorpsi dan kinetika adsorpsi. Hasil penelitian menunjukkan bahwa komposit zeolit magnetit dengan kristalinitas yang baik dan memiliki sifat kemagnetan berhasil disintesis menggunakan metode kopresipitasi. Komposit zeolit magnetit dengan kristalinitas paling baik terbentuk pada saat durasi pengadukan reaktan selama 1 menit. Adsorpsi Ni(II) oleh Komposit zeolit magnetit secara optimal terjadi pada waktu adsorpsi 100 menit dan mengikuti kinetika orde dua semu Ho dengan nilai konstanta laju adsorpsi (k) 1,45 x 10-3 g/mg menit. Uji pemisahan fasa padat pada komposit zeolit magnetit sebagai adsorben memerlukan waktu lebih cepat menggunakan medan magnet eksternal.
PEMBELAJARAN MENULIS KARANGAN EKSPOSISI MENGGUNAKAN MEDIA GAMBAR PESERTA DIDIK KELAS VIII SMPN 24 BANJARMASIN
Authors: Cita Puteri Erdanu Asha , Zulkifli  , Noortyani Rusma 
Published: January 2021

Tujuan penelitian ini yakni memaparkan proses dari pelaksanaan pembelajaran me nulis karangan eksposisi dengan penggunaan media gambar pada kelas VIII peserta didik SMP Negeri 24 Banjarmasin. Metode penelitian yang di gunakan pada penelitian ini adalah deskriptif kualitatif. Data pada penelitian ini dianalisis dengan cara (1) mereduksi data; (2) menyajikan data; dan (3) memverifikasi data atau mengkonklusi. Penelitian ini menghasilkan pemaparan mengenai pelaksanaan penbelajaran menulis karangan eksposisi menggunakan media gambar yang terdiri dari 3 langkah kegiatan, di antaranya (1) pendahuluan, berisi salam dan doa, menyiapkan fisik dan psikis peserta didik, serta memberikan motivasi; (2) inti, yang terdiri dari kegiatan 5 M, yaitu mengamati, menanya, mengumpulkan informasi, menalar informasi dan mengomunikasikan hasil; serta (3) penutup.
Resposta da fratura e integridade dos pirênios embebidos em água e GA3 na germinação de “muricis”
Authors: Barbosa Cylles Zara dos Reis , Mendonça Maria Sílvia de , Smiderle Oscar José 
Published: January 2021

A propagação das espécies de “muricis” é afetada pela dormência de suas sementes, e como ainda, não há um consenso sobre a causa e o método a ser utilizado para superar a dormência, objetivou-se, avaliar a resposta da fratura e integridade dos pirênios embebidos em água e GA3 na germinação de “muricis” (Byrsonima crassifolia (L.) Kunth., B. verbascifolia (L.) DC. e B. coccolobifolia Kunth.), de áreas de savanas de Boa Vista, Roraima. O experimento foi conduzido em delineamento inteiramente casualizado e esquema fatorial 3x3, composto por três espécies e três tratamentos pré-geminativos, com quatro repetições de 25 pirênios. Os tratamentos consistiram de pirênios imersos em solução de ácido giberélico (500 mg L-1), durante 48 horas e íntegros; imersos em água destilada, durante 48 horas e fraturados; e imersos em água destilada, durante 48 horas e íntegros. Os pirênios pertencem ao mesmo gênero, mas as espécies respodem de forma diferente aos tratamentos pré-germinativos para início, tempo médio e porcentagem de germinação, porém a imersão dos pirênios íntegros e em solução de ácido giberélico, foi o tratamento mais eficiente para superar a dormência nas sementes das três espécies de “muricis”.
A VOLTA DO GATO PRETO: a narrativa de viagem como jornalismo literário na obra do Dr. Erico Verissimo
Authors: Ritter Eduardo 
Published: January 2021

Desde a Grécia Antiga até a contemporaneidade, as narrativas de viagem são produzidas e publicadas com destaque no meio literário. No Brasil, a partir do século XX esse gênero ganha destaque no campo de produções joranalísticas. Erico Verissimo, jornalista, escritor e doutor em Literatura, foi um dos que deixou um rico legado nesse tipo de produção: quatro livros resultantes de viagens para Estados Unidos, México e Israel. Dessa maneira, o artigo investiga os elementos que permitem considerar o relato de viagem A volta do gato preto como uma narrativa que se enquadra no gênero Jornalismo Literário na categoria de livro-reportagem-viagem, proposta por Lima (2004). Para tanto, identificaram-se cinco temáticas principais que aparecem no enredo desse texto misto: viagem, família, universidade, cultura e guerra.
Palavras-chave: Jornalismo literário; História do jornalismo; Narrativa de viagem; Livro-reportagem; Erico Verissimo.
A TV PÚBLICA NO BRASIL E PORTUGAL: Aspectos conceituais e históricos
Authors: Menezes Gizeli Costa Bertollo , Porto Junior Francisco Gilson Rebouças , Silva Yuri Vinicius , Cruz Filho José Lopes da , Ferreira Kécia Garcia 
Published: January 2021

A proposta deste artigo é compreender melhor o sistema público de televisão em Portugal e no Brasil, especificamente as emissoras RTP1 e TV Brasil. Embora os dois países sejam marcados por fortes ligações históricas, culturais e linguísticas, se distanciam no que diz respeito a radiodifusão pública. Enquanto em Portugal a televisão já nasce sob o domínio estatal, que posteriormente vai se moldando aos princípios do serviço público, no Brasil chega pelas mãos da iniciativa privada, que por quase duas décadas dominou de forma exclusiva o cenário televisivo, imprimindo seu modelo no país.

PALAVRAS CHAVE: Televisão; Brasil; Portugal; TV pública; História.

ABSTRACT
The purpose of this article is to better understand the public television system in Portugal and Brazil, specifically the RTP1 and TV Brazil broadcasters. Although the two countries are marked by strong historical, cultural and linguistic connections, they are distant in relation to public broadcasting. While in Portugal, television is born under state domination, which later is shaping the principles of public service, in Brazil comes through the hands of private initiative, which for almost two decades dominated the television scene exclusively, printing its model in the country.

KEYWORDS: Television; Brazil; Portugal; Public TV; Story.

RESUMEN
El propósito de este trabajo es comprender mejor el sistema público de televisión en Portugal y Brasil, específicamente en las emisoras de televisión RTP 1 y Brasil. Aunque los dos países están marcados por fuertes vínculos históricos, culturales y lingüísticos, se distancian en lo que se refiere a la radiodifusión pública. Mientras que en Portugal la televisión nace bajo dominio del Estado, que posteriormente dar forma a los principios de servicio público en Brasil llega a manos de la empresa privada, que desde hace casi dos décadas dominaron exclusivamente el panorama de la televisión mediante la impresión de su modelo en el país .

PALABRAS CLAVES: Televisión; Brasil; Portugal; TV pública; Historia.
ANÁLISE DA SENSIBILIZAÇÃO DO JORNALISMO AMBIENTAL EM RIO GRANDE DO NORTE
Authors: Baracho Nicoler , Costa Grace Soares 
Published: January 2021

Este artigo apresenta alguns dos resultados obtidos no projeto de pesquisa que analisa a qualificação da cobertura jornalística da região sobre meio ambiente e ciência do jornal “Tribuna do Norte” (Natal/RN - http://www.tribunadonorte.com.br/), considerando a periodicidade que estas reportagens são publicadas e os critérios gerais do jornalismo e de seus gêneros científico e ambiental. O objetivo foi avaliar se a imprensa local informou eficientemente o seu público sobre as questões ambientais e suas consequências na região Nordeste. Assim, a partir da avaliação dos resultados, busca-se contribuir com a qualificação do conhecimento e informação que são repassados para o público leitor, de forma que possam tomar decisões esclarecidas sobre a temática.

PALAVRAS-CHAVE: Tribuna do Norte; Jornalismo Ambiental; Meio ambiente.

ABSTRACT
This article presents some of the results obtained in the research project that analyses the qualification of the journalistic coverage in the region about environment and science in the journal “Tribuna do Norte” (Natal/RN - http://www.tribunadonorte.com.br/), considering the periodicity in which these reports are published and the general criteria of journalism and its scientific and environmental genders. The goal was to evaluate if the local press efficiently informed its public about the environmental issues and its consequences in the Northeast region. Thus, from the evaluation of the results, we seek to contribute with the qualification of the knowledge and information that are passed on to the reading public, so that they can make enlightened decisions about the subject.

KEYWORDS: Tribuna do Norte; Environmental Journalism; Environment.

RESUMEN
Este artículo presenta algunos de los resultados obtenidos en el proyecto de pesquisa que estudia la calificación de la cobertura periodística de la región respecto al medio ambiente y ciencia del periódico "Tribuna do Norte" (Natal/RN - http://www.tribunadonorte.com.br/), llevando en cuenta la periodicidad en que estos repostajes son publicados y los criterios generales del periodismo y sus géneros cientifico y ambiental. El objetivo fue lo de evaluar si la imprenta local le informó a su publico de modo efectivo las cuestiones ambientales y sus consecuencias en la región Noreste. Así siendo, a partir de la evaluación de los resultados, se busca contribuir con la calificación del conocimiento y información que son repasados al público lector, de forma que puedan tomar decisiones aclaradas sobre el tema.
PALABRAS CLAVE: Tribuna do Norte; Periodismo Ambiental; Medio ambiente.
Uncovering New Challenges in Targeting Glycolysis to Treat Th17 Cell-Mediated Autoimmunity
Authors: Mosure Sarah A. , Solt Laura A. 
Published: January 2021

Abstract
Targeting glycolysis in T helper 17 (Th17) cells presents an attractive opportunity to treat Th17 cell-mediated autoimmune diseases such as multiple sclerosis (MS). Pyruvate kinase isoform 2 (PKM2) is a glycolytic enzyme expressed in T cells infiltrating the central nervous system in a mouse model of MS, suggesting PKM2 modulation could provide a new avenue for MS therapeutics. In a recent article in Science Signaling, Seki et al. show that pharmacological modulation of PKM2 alters but does not ameliorate disease in a mouse model of MS. These results warrant further consideration of PKM2 modulators to treat Th17 cell-mediated autoimmunity.
Efficacy of vafidemstat in experimental autoimmune encephalomyelitis highlights the KDM1A/RCOR1/HDAC epigenetic axis in multiple sclerosis
Authors: Cavalcanti Fernando , Gonzalez-Rey Elena , Delgado Mario , Mestre Leyre , Guaza Carmen , Lufino Michele MP , Xaus Jordi , Mascaró Cristina , Lunardi Serena , Sacilotto Natalia , Dessanti Paola , Rotllant David , Navarro Xavier , Herrando-Grabulosa Mireia , Buesa Carlos , Maes Tamara 
Published: January 2021

Abstract
Background Vafidemstat (ORY-2001) is a clinical stage inhibitor of the Lysine Specific Demethylase KDM1A in development for treatment of neurodegenerative and psychiatric diseases. KDM1A demethylates H3K4me1/2 and together with the histone deacetylases HDAC1/2, it forms part of co-repressor complexes recruited by zinc finger factors to control transcription. The exact role of KDM1A in neuroinflammation remained to be explored. Methods Compounds were administered p.o. gavage to mice with MOG35-55 induced experimental autoimmune encephalomyelitis or mice infected with Theiler’s murine encephalomyelitis virus. Immune cell infiltration was analyzed by immunohistochemistry. Cytokine and chemokine levels were analyzed by ELISA. Genome wide gene expression in spinal cord and brain were analyzed by two-color microarray analysis and qRT-PCR. Results ORY-2001 improved the clinical score in mouse experimental autoimmune encephalomyelitis and in mice infected with the Theiler’s murine encephalomyelitis virus. The compound reduced lymphocyte egress and infiltration of immune cells in the spinal cord and prevented demyelination. ORY-2001 was more effective and/or faster acting than a sphingosine 1-phosphate receptor antagonist in the effector phase of the disease and reduced the induction of the inflammatory gene expression signature in the central nervous system more potently. Gene expression changes and axonal protection in animals, and protection against glutamate excitoxicity in spinal cord explants support that ORY-2001 has neuroprotective qualities. Conclusions ORY-2001 exerts therapeutic activity in two mouse models of multiple sclerosis. The anti-inflammatory properties of ORY-2001 are being tested in a Phase IIa clinical trial in patients with relapse remitting and secondary progressive multiple sclerosis, and in severely ill COVID-19 patients at risk for acute respiratory distress syndrome.
Feather Biodegradation For Feather Protein Lysate/ Feather Meal Mutual Formations: Optimization Using Crude YNDH Protease/Keratinase; Enzyme Partial Purification and Characterization
Authors: Goda Doaa , Bassiouny Ahmad , Monem Nihad Abdel , Soliman Nadia , Fattah Yasser Abdel 
Published: January 2021

Abstract
Incubation parameters used for the production of a protein lysate from enzymatically degraded waste feather using crude keratinase produced by laceyella sacchari YNDH was optimized using RSM, amino acids quantification was estimated as well. The optimization resulted in total soluble protein 2089.5µg/ml. The optimal conditions were, time 20.2h, feather concentration 3g% and keratinase activity 24.5U/100ml at pH, 10; and cultivation temperature 50oC. The FPL was found enriched with essential and rare amino acids.In parallel, this YNDH enzyme group had been partially purified and some characteristics of it were studied. Crude enzymes were first concentrated with Amicon Ultra 10k centrifugal filter, and then concentrated proteins were applied to "QFF" strong anion column chromatography. The partially purified enzyme has an estimated molecular masses ranged 6 to 10 kDa. The maximum enzyme activity was observed at 70°C and pH 10.4 when measured by both casein and keratin azure as substrates. Interestingly, keratinolytic activity of this group was not affect by EDTA, PMSF and DTT. Generally the overall characters of this group protease/keratinase nearly the same when its activity was measured with both substrates suggesting that all these 3 protein bands working together as a group of keratinases.
Critical Care Ultrasound Oriented Shock Treatment in Intensive Care Unit: A Randomized Controlled Trial
Authors: Yin Wanhong , Qin Yao , Zou Tongjuan , Zeng Xueying , Li Yi , Ma Chengyong , Wang Dong , Yang Jing , Kang Hui , Liu Bingyang , Kang Yan , Wang Xiaoting , Chao Yangong , Zhang Lina 
Published: January 2021

Abstract
Objective: To determine whether our established Pathophysiology and etiology treatment for shock based on critical ultrasonography (PESCUS) workflow is superior to standard care in the setting of Intensive Care Unit (ICU). Materials and Methods: This is a prospective randomized controlled study. Critically ill adult shock patients were assigned to critical care ultrasound oriented treatment (CUOT) group who received treatment designed for different phases of shock guided by PESCUS workflow or standard care (SC) group who received standard care without treatment guided by PESCUS workflow.Results: Of the 147 enrolled patients, 77 were assigned to the CUOT group and 70 to the SC group. There were no significant difference between the two groups at baseline. The ICU mortality in CUOT group was significantly lower (29.9% vs. 45.7%, P=0.047). The CUOT group received significantly less fluid than SC group in the stabilization and de-escalation phases. The median duration of stabilization and de-escalation phase of shock in CUOT group was 35.0 [IQR 19.3-59.8] hours compared with 60.0[IQR 24.0-78.0] hours in SC group, p=0.024). Conclusions: Our study suggests utilization of PESCUS workflow can potentially improve ICU outcome in shock patient and avoid unnecessary fluid overload during shock recovery phase. Trial registration: Critical Care Ultrasound Oriented Shock Treatment in ICU, (28/03/2017) NCT03093987，Registered, Retrospectively registered .
Respiratory syncytial virus infection is an underestimated cause of viral pneumoniae in adults
Authors: Schubert Lorenz , Steininger Johanna , Lötsch Felix , Herdina Anna Nele , Monika Redlberger-Fritz , Tobudic Selma , Kundi Michael , Strassl Robert , Steininger Christoph 
Published: January 2021

Abstract
Respiratory syncytial virus (RSV) testing is generally available in most care centres, but it is rarely performed because clinicians’ seldom suspect RSV to be the underlying pathogen in adults with respiratory disease. Here, we evaluate the impact of broad combined influenza/RSV testing on the clinical practice. Overall, 103 patients were tested positively for RSV. Our study indicates that positively tested patients were mostly of advanced age and suffered from chronic diseases. Mortality was significant in our cohort and higher in patients with advanced age. Further, we report a significant increase in detected RSV cases but also in detection rate. Together, these findings suggest that implementation of a combined influenza/RSV testing led to a significant increase in detection rate, supported clinicians establishing the correct diagnosis and allowed a safe and controlled handling of RSV patients.
Trans-ethnic eQTL meta-analysis of human brain reveals regulatory architecture and candidate causal variants for brain-related traits
Authors: Hoffman Gabriel , Zeng Biao , Bendl Jaroslav , Kosoy Roman , Fullard John , Roussos Panos 
Published: January 2021

Abstract
While large-scale genome-wide association studies (GWAS) have identified hundreds of loci associated with neuropsychiatric and neurodegenerative traits, identifying the variants, genes and molecular mechanisms underlying these traits remains challenging. Integrating GWAS results with expression quantitative trait loci (eQTLs) and identifying shared genetic architecture has been widely adopted to nominate genes and candidate causal variants. However, this integrative approach is often limited by the sample size, the statistical power of the eQTL dataset, and the strong linkage disequilibrium between variants. Here we developed the multivariate multiple QTL (mmQTL) approach and applied it to perform a large-scale trans-ethnic eQTL meta-analysis to increase power and fine-mapping resolution. Importantly, this method also increases power to identify conditional eQTL’s that are enriched for cell type specific regulatory effects. Analysis of 3,188 RNA-seq samples from 2,029 donors, including 444 non-European individuals, yields an effective sample size of 2,974, which is substantially larger than previous brain eQTL efforts. Joint statistical fine-mapping of eQTL and GWAS identified 301 variant-trait pairs for 23 brain-related traits driven by 189 unique candidate causal variants for 179 unique genes. This integrative analysis identifies novel disease genes and elucidates potential regulatory mechanisms for genes underlying schizophrenia, bipolar disorder and Alzheimer’s disease.
The Association of Malnutrition, Illness Duration, and Pre-morbid Weight Status with Anxiety and Depression Symptoms in Adolescents and Young Adults with Restrictive Eating Disorders: A Cross-Sectional Study.
Authors: Lin Jessica Ann , Jhe Grace , Vitagliano Julia A , Milliren Carly E , Spigel Rebecca , Woods Elizabeth R , Forman Sara F , Richmond Tracy K 
Published: January 2021

Abstract
BackgroundRestrictive eating disorders (EDs) are often comorbid with anxiety and depression, placing patients at risk for more severe disease, worse treatment outcomes, and higher rates of mortality. To identify risks for developing such co-morbidities, we assessed the association of malnutrition, ED illness duration, and pre-morbid weight status with symptoms of anxiety and depression in adolescents/young adults (AYAs) with EDs. Methods145 participants with restrictive EDs (anorexia nervosa [AN], otherwise specified eating or feeding disorder [OSFED], avoidant restrictive food intake disorder [ARFID]) were included from the RECOVERY study, a longitudinal web-based registry of AYAs with EDs. We measured malnutrition as percent of expected body mass index (%eBMI), based on participants’ pre-morbid growth trajectory. Outcomes were anxiety and depression scores from the Generalized Anxiety Disorder 7-item (GAD-7) and Center for Epidemiologic Studies Depression (CES-D) scales. We used multiple linear regression to examine the association of malnutrition, ED duration, and pre-morbid weight status with symptoms of anxiety and depression. ResultsMean(SD) age was 16.4(3.0) years; 87% were female; 89% white; 85% had AN, 6% OSFED, 10% ARFID. Of these, 2/3 had ED symptoms ≥1 year, 1/3 had previous higher level of ED care (HLOC), and half were taking psychiatric medications. Mean %eBMI was 90% (range 57-112%). Mean GAD-7 was 9.4(5.9) and CES-D was 24(13.8), indicating most participants had clinically significant anxiety and/or depression. Degree of malnutrition was not significantly associated with anxiety or depression adjusting for age, sex, sexual orientation, ED diagnosis, and use of psychiatric medication. Those with longer duration of ED symptoms had higher depression (p=0.038) scores after adjusting for malnutrition, HLOC, length of ED symptoms, and time in our care. Patients with pre-morbid BMIs ≥75th percentile had lower depression scores than those with pre-morbid BMIs <75th percentile (p=0.014).ConclusionsWe find high degree of clinically relevant anxiety and depression in a population of AYAs with EDs. Our findings suggest that factors beyond malnutrition play a role in the co-morbid mood and anxiety disorders in this population. Overall, rapid ED diagnosis and comprehensive treatment for patients with EDs across the weight spectrum—and especially those with psychiatric co-morbidities—will likely aid in recovery.
Language Diversity and Challenges to Communication in Indian Emergency Departments
Authors: Douglass Katherine , Narayan Lalit , Allen Rebecca , Pandya Jay , Talib Zohray 
Published: January 2021

Abstract
BackgroundCommunication in emergency departments (ED) in India is complicated by the country’s immense language diversity. Prior research has revealed challenges in language and communication as barriers to care. Our objective was to quantify language diversity among clinicians in Indian EDs and better understand issues related to clinician-clinician and clinician-patient communicationMethodologyA cross-sectional survey of ED clinicians was conducted. Survey participants were recruited in-person and through email at six partner sites in India. ANOVA and binary logistic regression were used for subgroup analysis. Semi-structured interviews were conducted with ED clinicians. Interview data was analyzed using the rapid assessment process to determine predominant themes.Results 106 clinicians completed the survey. On average, clinicians spoke 3.75 languages. 71% used a non-English language to speak to fellow clinicians most of the time. 53% reported at least one critical incident over the last year where poor communication played a part. Interviews revealed challenges including low health literacy, high patient volume,and workplace hierarchy.Conclusions This study is the first to document the impact of language diversity and communication barriers in Indian EDs. The results highlight the need for effective strategies to improve communication that account for the multiple languages spoken by clinicians and patients.