bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using targeted cognitive behavioural therapy in clinical work: a case study
Authors: Harris Olivia , Kustner Claudia , Paskell Rachel , Hannay Chris 
Published: January 2021

Abstract
Research shows high levels of complex co-morbidities within psychiatric populations, and there is an increasing need for mental health practitioners to be able to draw on evidence-based psychological interventions, such as cognitive behavioural therapy (CBT), to work with this population effectively. One way CBT may be utilised when working with complexity or co-morbidity is to target treatment at a particular aspect of an individual’s presentation. This study uses a single-case A-B design to illustrate an example of using targeted diagnosis-specific CBT to address symptoms of a specific phobia of stairs in the context of a long-standing co-morbid diagnosis of schizophrenia. Results show the intervention to have been effective, with a change from a severe to mild phobia by the end of intervention. Clinical implications, limitations and areas for future research are discussed.

Key learning aims

(1)
There are high levels of co-morbid, complex mental health problems within psychiatric populations, and an increasing need for mental health practitioners to be able to work with co-morbidity effectively.

(2)
Cognitive behavioural therapy (CBT) remains one of the most well-evidenced psychological interventions with a large amount of research highlighting the effectiveness of diagnosis-specific CBT.

(3)
One way evidence-based diagnosis-specific CBT approaches could be utilised when working with more complex co-morbidity may be to target an intervention at a specific set of symptoms.

(4)
An example of using a targeted CBT intervention (to tackle a specific phobia of stairs in the context of a long-standing co-morbid diagnosis of schizophrenia and ongoing hallucinations) is presented. The outcomes show significant changes in the specific phobia symptoms, suggesting that CBT can be effectively used in this targeted manner within real-world clinical settings. The impact of co-morbid mental health difficulties on therapeutic process and outcomes are highlighted.

(5)
The use of cognitive restructuring techniques was identified as key to engagement and therapeutic process, supporting the importance of including cognitive techniques in the treatment of phobias compared with purely behavioural exposure-based interventions.
Landslide Hazard and Exposure Modelling in Data‐Poor Regions: The Example of the Rohingya Refugee Camps in Bangladesh
Authors: Emberson R. A. , Kirschbaum D. B. , Stanley T. 
Published: January 2021

AbstractLandslide hazards significantly affect economies and populations around the world, but locations where the greatest proportional losses occur are in data‐poor regions where capacity to estimate and prepare for these hazards is most limited. Earth observation (EO) data can fill key knowledge gaps, and can be rapidly used in settings with lower analytical capacity. In this study, we describe a novel series of methods designed to analyze landslide susceptibility, hazard and exposure in the region in and around the Rohingya refugee camps in Bangladesh, where limited data is juxtaposed with a major humanitarian crisis. We demonstrate that a high degree of accuracy is possible even when estimating susceptibility of relatively small landslides. In the context of this example, we also explore how estimates of landslide hazard and exposure are most beneficial to decisions made by humanitarian stakeholders relevant to natural hazards and risk. The unique opportunity to work alongside humanitarian end‐users has allowed us to produce focused products that can be tested while in development. In particular, we stress the importance of communicating the difference between a landslide “early warning system”—for which satellite data may be unsuitable at local scales—and a model that provides relative hazard estimates, where EO may be valuable. The toolbox of methods presented here could be used to generate landslide hazard and exposure maps in other data‐poor regions around the globe.
Biases in Indian Summer Monsoon Precipitation Forecasts in the Unified Model and Their Relationship With BSISO Index
Authors: Keane R. J. , Parker D. J. , Fletcher J. K. 
Published: January 2021

AbstractThis study shows that the Boreal Summer Intraseasonal Oscillation (BSISO) dominates the Indian summer monsoon low‐precipitation bias in the Met Office Unified model. Analyzing a recent 9‐year period (June, July, August only), it is found that the precipitation bias is dominated by break and break‐to‐active transition BSISO phases, while some of the other phases have no bias at all over a 7‐day forecast. Evidence of a link to upstream effects is found, in that there is a delayed reduction in the moisture flux entering India from the west. It is also shown that an increase in the net flow of moisture out of India to the east is strongly linked to the low‐precipitation bias, and there is some evidence that this is related to a lack of low‐pressure systems over India. Most atmospheric models have substantial rainfall biases over India, and these results may indicate the circulation patterns responsible.
Absorbent Porous Paper Reveals How Earthquakes Could be Mitigated
Authors: Tzortzopoulos G. , Braun P. , Stefanou I. 
Published: January 2021

AbstractEarthquakes nucleate when large amounts of elastic energy, stored in the earth's crust, are suddenly released due to abrupt sliding over a fault. Fluid injections can reactivate existing seismogenic faults and induce/trigger earthquakes by increasing fluid pressure. Here we develop an analogous experimental system of simultaneously loaded and wetted absorbent porous paper to quantify theoretically the process of wetting‐induced earthquakes. This strategy allows us to gradually release the stored energy by provoking low intensity tremors. We identify the key parameters that control the outcome of the applied injection strategy, which include the initial stress state, fault segmentation, and segment‐activation rate. Subsequent injections, initiated at high stress levels, can drive the system faster toward its instability point, nucleating a large earthquake. Starting at low stress levels, however, they can reduce the magnitude of the natural event by at least one unit.
Role of the Moist and Dry Components of Moist Isentropic Mass Circulation in Changing the Extratropical Surface Temperature in Winter
Authors: Liang Ruxue , Yu Yueyue , Shi Chunhua , Guan Zhaoyong 
Published: January 2021

AbstractThis study separates the dry and moist components of the moist isentropic mass circulation (MIMC) on a daily timescale and investigates their relationships with extratropical surface temperature changes in winter (November to February). Results from ERA5 reanalysis data set (1979–2018) show that the MIMC is composed of a poleward warm branch in the upper layers and an equatorward cold branch below. The warm branch (WB) is dominated by the moist component in the mid‐latitude troposphere, but by the dry component in other regions. The stronger moist component of WB at 50°N‐70°N (WB_M) is a better precursory indicator than the dry component (WB_D) for the Arctic surface warming as a result of its dominant role in modifying the downward longwave radiation via water‐vapor‐related processes. The stronger WB_D is coupled with a negative Arctic Oscillation and a stronger, longer‐lasting equatorward transport of colder air, therefore a better precursory indicator of mid‐latitude cold events.
Reconstruction of Magnetospheric Storm‐Time Dynamics Using Cylindrical Basis Functions and Multi‐Mission Data Mining
Authors: Tsyganenko N. A. , Andreeva V. A. , Sitnov M. I. 
Published: January 2021

AbstractFirst results are presented of the modeling of magnetospheric storm events, based on: (i) a new method to represent the magnetic field by means of the so‐called cylindrical basis functions, (ii) the data mining approach by Sitnov et al. (2008); https://doi.org/10.1029/2007ja013003, and (iii) upgraded and extended pool of multi‐mission data taken in 1995–2019. The study is focused on the low‐latitude magnetospheric domain in the distance range 3–18RE bounded by field line shells with footpoint latitudes ±70°. The magnetic configurations are reconstructed from data subsets, selected from the grand database by the nearest‐neighbor method, using both interplanetary data and the ground disturbance indices. A strong storm of May 27–29, 2017, has been studied in relation to its effect on the reconfiguration of the low‐latitude magnetosphere. The modeling reproduces the main features of the magnetosphere dynamics in terms of the geomagnetic field depression/compression and extremely variable field line stretching. The initial contraction of the magnetosphere during the storm sudden commencement results in a local transient surge of the inner tail current and a dramatic antisunward discharge of the magnetic flux. As the storm progresses, the ring current buildup results in a strongly depressed magnetic field in the inner magnetosphere, which expels the magnetic flux to larger distances and increases the field line connection across the more distant tail plasma sheet. At the same time, a strong dawn‐dusk asymmetry is developed due to the formation of the duskside partial ring current, in agreement with previous independent results.
Chemical Interactions Between Ship‐Originated Air Pollutants and Ocean‐Emitted Halogens
Authors: Li Qinyi , Badia Alba , Fernandez Rafael P. , Mahajan Anoop S. , López‐Noreña Ana Isabel , Zhang Yan , Wang Shanshan , Puliafito Enrique , Cuevas Carlos A. , Saiz‐Lopez Alfonso 
Published: January 2021

AbstractOcean‐going ships supply products from one region to another and contribute to the world’s economy. Ship exhaust contains many air pollutants and results in significant changes in marine atmospheric composition. The role of reactive halogen species (RHS) in the troposphere has received increasing recognition and oceans are the largest contributors to their atmospheric burden. However, the impact of shipping emissions on RHS and that of RHS on ship‐originated air pollutants have not been studied in detail. Here, an updated Weather Research Forecasting coupled with Chemistry model is utilized to explore the chemical interactions between ship emissions and oceanic RHS over the East Asia seas in summer. The emissions and resulting chemical transformations from shipping activities increase the level of NO and NO2 at the surface, increase O3 in the South China Sea, but decrease O3 in the East China Sea. Such changes in pollutants result in remarkable changes in the levels of RHS (>200% increase of chlorine; ∼30% and ∼5% decrease of bromine and iodine, respectively) as well as in their partitioning. The abundant RHS, in turn, reshape the loadings of air pollutants (∼20% decrease of NO and NO2; ∼15% decrease of O3) and those of the oxidants (>10% reduction of OH and HO2; ∼40% decrease of NO3) with marked patterns along the ship tracks. We, therefore, suggest that these important chemical interactions of ship‐originated emissions with RHS should be considered in the environmental policy assessments of the role of shipping emissions in air quality and climate.
Demonstration of tantalum as a structural material for MEMS thermal actuators
Authors: Ni Longchang , Pocratsky Ryan M. , de Boer Maarten P. 
Published: January 2021

AbstractThis work demonstrates the processing, modeling, and characterization of nanocrystalline refractory metal tantalum (Ta) as a new structural material for microelectromechanical system (MEMS) thermal actuators (TAs). Nanocrystalline Ta films have a coefficient of thermal expansion (CTE) and Young’s modulus comparable to bulk Ta but an approximately ten times greater yield strength. The mechanical properties and grain size remain stable after annealing at temperatures as high as 1000 °C. Ta has a high melting temperature (Tm = 3017 °C) and a low resistivity (ρ = 20 µΩ cm). Compared to TAs made from the dominant MEMS material, polycrystalline silicon (polysilicon, Tm = 1414 °C, ρ = 2000 µΩ cm), Ta TAs theoretically require less than half the power input for the same force and displacement, and their temperature change is half that of polysilicon. Ta TAs operate at a voltage 16 times lower than that of other TAs, making them compatible with complementary metal oxide semiconductors (CMOS). We select α-phase Ta and etch 2.5-μm-thick sputter-deposited films with a 1 μm width while maintaining a vertical sidewall profile to ensure in-plane movement of TA legs. This is 25 times thicker than the thickest reactive-ion-etched α-Ta reported in the technical literature. Residual stress sensitivities to sputter parameters and to hydrogen incorporation are investigated and controlled. Subsequently, a V-shaped TA is fabricated and tested in air. Both conventional actuation by Joule heating and passive self-actuation are as predicted by models.
Host population diversity as a driver of viral infection cycle in wild populations of green sulfur bacteria with long standing virus-host interactions
Authors: Berg Maureen , Goudeau Danielle , Olmsted Charles , McMahon Katherine D , Yitbarek Senay , Thweatt Jennifer L , Bryant Donald A , Eloe-Fadrosh Emiley A , Malmstrom Rex R , Roux Simon 
Published: January 2021

Abstract
Temperate phages are viruses of bacteria that can establish two types of infection: a lysogenic infection in which the virus replicates with the host cell without producing virions, and a lytic infection where the host cell is eventually destroyed, and new virions are released. While both lytic and lysogenic infections are routinely observed in the environment, the ecological and evolutionary processes regulating these viral dynamics are still not well understood, especially for uncultivated virus-host pairs. Here, we characterized the long-term dynamics of uncultivated viruses infecting green sulfur bacteria (GSB) in a model freshwater lake (Trout Bog Lake, TBL). As no GSB virus has been formally described yet, we first used two complementary approaches to identify new GSB viruses from TBL; one in vitro based on flow cytometry cell sorting, the other in silico based on CRISPR spacer sequences. We then took advantage of existing TBL metagenomes covering the 2005–2018 period to examine the interactions between GSB and their viruses across years and seasons. From our data, GSB populations in TBL were constantly associated with at least 2-8 viruses each, including both lytic and temperate phages. The dominant GSB population in particular was consistently associated with two prophages with a nearly 100% infection rate for &gt;10 years. We illustrate with a theoretical model that such an interaction can be stable given a low, but persistent, level of prophage induction in low-diversity host populations. Overall, our data suggest that lytic and lysogenic viruses can readily co-infect the same host population, and that host strain-level diversity might be an important factor controlling virus-host dynamics including lytic/lysogeny switch.
Mesopelagic microbial carbon production correlates with diversity across different marine particle fractions
Authors: Baumas Chloé M J , Le Moigne Frédéric A C , Garel Marc , Bhairy Nagib , Guasco Sophie , Riou Virginie , Armougom Fabrice , Grossart Hans-Peter , Tamburini Christian 
Published: January 2021

Abstract
The vertical flux of marine snow particles significantly reduces atmospheric carbon dioxide concentration. In the mesopelagic zone, a large proportion of the organic carbon carried by sinking particles dissipates thereby escaping long term sequestration. Particle associated prokaryotes are largely responsible for such organic carbon loss. However, links between this important ecosystem flux and ecological processes such as community development of prokaryotes on different particle fractions (sinking vs. non-sinking) are yet virtually unknown. This prevents accurate predictions of mesopelagic organic carbon loss in response to changing ocean dynamics. Using combined measurements of prokaryotic heterotrophic production rates and species richness in the North Atlantic, we reveal that carbon loss rates and associated microbial richness are drastically different with particle fractions. Our results demonstrate a strong negative correlation between prokaryotic carbon losses and species richness. Such a trend may be related to prokaryotes detaching from fast-sinking particles constantly enriching non-sinking associated communities in the mesopelagic zone. Existing global scale data suggest this negative correlation is a widespread feature of mesopelagic microbes.
Unexpectedly high mutation rate of a deep-sea hyperthermophilic anaerobic archaeon
Authors: Gu Jiahao , Wang Xiaojun , Ma Xiaopan , Sun Ying , Xiao Xiang , Luo Haiwei 
Published: January 2021

Abstract
Deep-sea hydrothermal vents resemble the early Earth, and thus the dominant Thermococcaceae inhabitants, which occupy an evolutionarily basal position of the archaeal tree and take an obligate anaerobic hyperthermophilic free-living lifestyle, are likely excellent models to study the evolution of early life. Here, we determined that unbiased mutation rate of a representative species, Thermococcus eurythermalis, exceeded that of all known free-living prokaryotes by 1-2 orders of magnitude, and thus rejected the long-standing hypothesis that low mutation rates were selectively favored in hyperthermophiles. We further sequenced multiple and diverse isolates of this species and calculated that T. eurythermalis has a lower effective population size than other free-living prokaryotes by 1-2 orders of magnitude. These data collectively indicate that the high mutation rate of this species is not selectively favored but instead driven by random genetic drift. The availability of these unusual data also helps explore mechanisms underlying microbial genome size evolution. We showed that genome size is negatively correlated with mutation rate and positively correlated with effective population size across 30 bacterial and archaeal lineages, suggesting that increased mutation rate and random genetic drift are likely two important mechanisms driving microbial genome reduction. Future determinations of the unbiased mutation rate of more representative lineages with highly reduced genomes such as Prochlorococcus and Pelagibacterales that dominate marine microbial communities are essential to test these hypotheses.
The combination of malnutrition-inflammation and functional status limitations is associated with mortality in hemodialysis patients
Authors: Kanda Eiichiro , Lopes Marcelo Barreto , Tsuruya Kazuhiko , Hirakata Hideki , Iseki Kunitoshi , Karaboyas Angelo , Bieber Brian , Jacobson Stefan H. , Dasgupta Indranil , Robinson Bruce M. 
Published: January 2021

AbstractThe identification of malnutrition-inflammation-complex (MIC) and functional status (FS) is key to improving patient experience on hemodialysis (HD). We investigate the association of MIC and FS combinations with mortality in HD patients. We analyzed data from 5630 HD patients from 9 countries in DOPPS phases 4–5 (2009–2015) with a median follow-up of 23 [IQR 11, 31] months. MIC was defined as serum albumin < 3.8 g/dL and serum C-reactive protein > 3 mg/L in Japan and > 10 mg/L elsewhere. FS score was defined as the sum of scores from the Katz Index of Independence in Activities of Daily Living and the Lawton-Brody Instrumental Activities of Daily Living Scale. We investigated the association between combinations of MIC (+/−) and FS (low [< 11]/high [≥ 11]) with death. Compared to the reference group (MIC−/high FS), the adjusted hazard ratios [HR (95% CI)] for all-cause mortality were 1.82 (1.49, 2.21) for MIC−/low FS, 1.57 (1.30, 1.89) for MIC+/high FS, and 3.44 (2.80, 4.23) for MIC+/low FS groups. Similar associations were observed with CVD-related and infection-related mortality. The combination of MIC and low FS is a strong predictor of mortality in HD patients. Identification of MIC and poor FS may direct interventions to lessen adverse clinical outcomes in the HD setting.
Lactobacillus reuteri AN417 cell-free culture supernatant as a novel antibacterial agent targeting oral pathogenic bacteria
Authors: Yang Kyung Mi , Kim Ji-Sun , Kim Hye-Sung , Kim Young-Youn , Oh Jeong-Kyu , Jung Hye-Won , Park Doo-Sang , Bae Kwang-Hak 
Published: January 2021

AbstractLactobacillus reuteri AN417 is a newly characterized probiotic strain. The activity of AN417 against oral pathogenic bacteria is unknown. We investigated the antibacterial activity of cell-free L. reuteri AN417 culture supernatant (LRS) against three oral pathogens: Porphyromonas gingivalis, Fusobacterium nucleatum, and Streptococcus mutans. P. gingivalis and F. nucleatum have been implicated in periodontal disease, whereas S. mutans causes dental caries. Exposing these oral pathogenic bacteria to LRS significantly reduced their growth rates, intracellular ATP levels, cell viability, and time-to-kill. The minimal inhibitory volume of LRS was 10% (v/v) against P. gingivalis, 20% (v/v) for F. nucleatum, and 30% (v/v) for S. mutans. LRS significantly reduced the integrity of biofilms and significantly suppressed the expression of various genes involved in P. gingivalis biofilm formation. The L. reuteri AN417 genome lacked genes encoding reuterin, reuteran, and reutericyclin, which are major antibacterial compounds produced in L. reuteri strains. LRS treated with lipase and α-amylase displayed decreased antibacterial activity against oral pathogens. These data suggest that the antibacterial substances in LRS are carbohydrates and/or fatty acid metabolites. Our results demonstrate that LRS has antimicrobial activity against dental pathogenic bacteria, highlighting its potential utility for the prevention and treatment of P. gingivalis periodontal disease.