bluuebunny/crossref_metadata_2025_split huggingface dataset:
Make the apps stand out: discoverability and perceived value are vital for adoption
Authors: Jiang Ling , Zhou Wenkai , Ren Zhuoyi , Yang Zhilin 
Published: September 2021

PurposeFrom an environmental psychology perspective, we aim to uncover the role that app discoverability facilitators play in enabling the various perceived values (e.g. social, information and hedonic) necessary for app adoption.Design/methodology/approachA survey study was conducted and data was analyzed using partial least squares structural equation modeling (PLS-SEM).FindingsResults show that certain consumer review elements (i.e. review quality, review quantity and app ranking), peer influence and app developers' reputation — to varying degrees — influence the three perceived values, which subsequently affect users' app adoption intention. The three perceived values mediate the relationship between app discoverability facilitators and users' app adoption intention.Practical implicationsApp store managers and developers should make a greater effort to effectively optimize discoverability and product differentiation.Originality/valueGuided by environmental psychology, we confirm the importance of app discoverability facilitators regarding their influence on users' general perceptions of an app (e.g. the three perceived values). We also uncover the differentiated effect of the three perceived values on app adoption intention.
Furthering systems theory towards social theory by revisiting critical systems thinking: connecting problem-solving and theory-building
Authors: Lo Shih-Hui , Liu Cheng-Da 
Published: September 2021

PurposeThe purpose is to forward systems theory one more step towards social theory and integrate problem-solving and theory-building, and search for the integration and unity of science by revealing the nature and role of critical systems thinking (CST).Design/methodology/approachThis article describes relations between systems theory and social theory in three parts. First, it examines the links of systems methodologies with three social science approaches as well as the role of CST. Second, the focus of theory and the form of explanation are discussed from critical social science (CSS) perspective. Third, the direction of theorizing of a CST-based systems theory is investigated.FindingsFirst, CST is a hidden assumption of system dynamics (SD)/systems thinking (ST). Second, systems theory is positioned in CSS. Third, CST integrates traditional and soft systems methodologies (SSM), and connects systems science and social science. Fourth, this article reveals hidden links between systems approaches and three corresponding social science approaches. Fifth, the theoretical focus of a CST-based systems theory could be formal/structure theory and/or substantive/content theory. Sixth, the form of explanation could be structural/mechanismic explanation combining causal and interpretive explanations. Seventh, a CST-based systems theory may adopt abduction, which complements a defect in deduction and induction in a difficulty of nonlinearity.Originality/valueIt illustrates a graph of the competing approaches in systems science corresponding to paradigms in social science.
Do social media data indicate visits to tourist attractions? A case study of Shanghai, China
Authors: Liang Huilin , Zhang Qingping 
Published: September 2021

PurposeCan Chinese social media data (SMD) be used as an alternative to traditional surveys used to understand tourists' visitation of attractions in Chinese cities? The purpose of this paper is to explore this question.Design/methodology/approachPopular tourism SMD sources in China, such as Ctrip, Weibo and Dazhong Dianping (DZDP), were used as data source, and the relationships between these sources and traditional data sources were studied with statistical methods. Data from Shanghai were used in this study since it is rich in tourism resources and developed in information.FindingsA systematic research method was followed and led to the following conclusions: There were positive correlations for attraction visitation between Chinese SMD and traditional survey data; Chinese SMD source could temporally indicate visits to Shanghai tourist attractions; Ctrip SMD generally performed less well than Weibo or DZDP, and different SMD performed differently depending on the specific attractions and time units in the visitation calculation process; and factors including visitation, distance from the city center and the grade of attractions might affect the prediction performance based on data from the SMD. The findings suggest that Chinese SMD could be used as a cost-efficient and reliable proxy for traditional survey data to predict Chinese attraction visitation.Originality/valueThis study applies and improves the methods of SMD reliability in attraction use studies, supplies the gap for premise, basis and foundation for the large amounts of tourism researches using SMD in China and could promote and inspire more efficient and advanced measures in tourism management and urban development.
The informalization of doctor–patient relations in a Finnish setting: New social figurations and emergent possibilities
Authors: Wilkinson Iain , Vaananen Ari 
Published: September 2021

AbstractThis article features data drawn from interviews with doctors working in the Finnish occupational health‐care system. These are used to explore the value of an Eliasian approach towards interpreting and assessing the moral meanings and social dynamics of relationships between health practitioners and their patients. We attend to spiralling ‘formalizing’ and ‘informalizing’ processes and how these are operating to reconfigure doctor–patient relationships. We document some of the ways in which Finnish doctors are adapting to these processes. While data drawn from a British context suggest both doctor and patients are inclined to adopt positions of mutual distrust and hostility, by contrast we note that in this Finnish setting more concerted attempts are being made to renegotiate social roles, cultural meanings and individual responsibilities. We propose that this can be taken as an instance where informalization is accompanied by revitalized currents of formalization and new syntheses of moral codes and conduct.
The unexplored role of sedentary time and physical activity in glucose and lipid metabolism‐related placental mRNAs in pregnant women who are obese: the DALI lifestyle randomised controlled trial
Authors: Acosta‐Manzano P , Leopold‐Posch B , Simmons D , Devlieger R , Galjaard S , Corcoy R , Adelantado JM , Dunne F , Harreiter J , Kautzky‐Willer A , Damm P , Mathiesen ER , Jensen DM , Andersen LL , Tanvig M , Lapolla A , Dalfra MG , Bertolotto A , Wender‐Ozegowska E , Zawiejska A , Hill DJ , Snoek FJ , Jelsma JGM , Desoye G , van Poppel MNM 
Published: September 2021

ObjectiveWe aimed to explore: (i) the association of sedentary time (ST) and physical activity (PA) during pregnancy with the placental expression of genes related to glucose and lipid metabolism in pregnant women who are obese; (ii) maternal metabolic factors mediating changes in these placental transcripts; and (iii) cord blood markers related to the mRNAs mediating neonatal adiposity.DesignMulticentre randomised controlled trial.SettingHospitals in nine European countries.PopulationA cohort of 112 pregnant women with placental tissue.MethodsBoth ST and moderate‐to‐vigorous PA (MVPA) levels were measured objectively using accelerometry at three time periods during pregnancy.Main outcome measuresPlacental mRNAs (FATP2, FATP3, FABP4, GLUT1 and PPAR‐γ) were measured with NanoString technology. Maternal and fetal metabolic markers and neonatal adiposity were assessed.ResultsLonger periods of ST, especially in early to middle pregnancy, was associated with lower placental FATP2 and FATP3 expression (P < 0.05), whereas MVPA at baseline was inversely associated with GLUT1 mRNA (P = 0.02). Although placental FATP2 and FATP3 expression were regulated by the insulin–glucose axis (P < 0.05), no maternal metabolic marker mediated the association of ST/MVPA with placental mRNAs (P > 0.05). Additionally, placental FATP2 expression was inversely associated with cord blood triglycerides and free fatty acids (FFAs; P < 0.01). No cord blood marker mediated neonatal adiposity except for cord blood leptin, which mediated the effects of PPAR‐γ on neonatal sum of skinfolds (P < 0.05).ConclusionsIn early to middle pregnancy, ST is associated with the expression of placental genes linked to lipid transport. PA is hardly related to transporter mRNAs. Strategies aimed at reducing sedentary behaviour during pregnancy could modulate placental gene expression, which may help to prevent unfavourable fetal and maternal pregnancy outcomes.Tweetable abstractReducing sedentary behaviour in pregnancy might modulate placental expression of genes related to lipid metabolism in women who are obese.
What is an appropriate caesarean delivery rate for China: a multicentre survey
Authors: Zhang Y , Betran AP , Li X , Liu D , Yuan N , Shang L , Lin W , Tu S , Wang L , Wu X , Zhu T , Zhang Y , Lu Z , Zheng L , Gu C , Fang J , Liu Z , Ma L , Cai Z , Yang X , Li H , Zhang H , Zhao X , Yan L , Wang L , Sun X , Luo Q , Liu L , Zhu J , Qin W , Yao Q , Dong S , Yang Y , Cui Z , He Y , Feng X , He L , Zhang H , Zhang L , Wang X , Souza JP , Qi H , Duan T , Zhang J 
Published: September 2021

ObjectiveTo assess the current status of caesarean delivery (CD) in China, propose reference CD rates for China overall, and by regions, investigate the main indications for CDs and identify possible areas for safe reduction.DesignA multicentre cross‐sectional study.SettingA total of 94 hospitals across 23 provinces in China.PopulationA total of 73 977 randomly selected deliveries.MethodsWe used a modified Robson classification to characterise CDs in subgroups and by regions, and the World Health Organization (WHO) C‐Model to calculate reference CD rates.Main outcome measuresCD rates in China.ResultsIn 2015–2016, the overall CD rate in China was 38.9% (95% CI 38.6–39.3%). Considering the obstetric characteristics of the population, the multivariable model‐based reference CD rate was estimated at 28.5% (95% CI 28.3–28.8%). Accordingly, an absolute reduction of 10.4% (or 26.7% relative reduction) may be considered. The CD rate varied substantially by region. Previous CD was the most common indication in all regions, accounting for 38.2% of all CDs, followed by maternal request (9.8%), labour dystocia (8.3%), fetal distress (7.7%) and malpresentation (7.6%). Overall, 12.7% of women had prelabour CDs, contributing to 32.8% of the total CDs.ConclusionsNearly 39% of births were delivered by caesarean in China but a reduction of this rate by a quarter may be considered attainable. Repeat CD contributed more than one‐third of the total CDs. Given the large variation in maternal characteristics, region‐specific or even hospital‐specific reference CD rates are needed for precision management of CD.Tweetable abstractThe caesarean rate in 2015–2016 in China was 38.9%, whereas the reference rate was 28.5%.
The effect of real estate prices on peer firms
Authors: Kjenstad Einar C. , Kumar Anil 
Published: September 2021

AbstractWe investigate peer effects from corporate real estate. Shocks to real estate prices shift firms' debt capacity, which has a significant impact not only on firm investment but also on the investment of peer firms. This peer effect from corporate real estate is stronger when firms or their peers have more investment opportunities; financially constrained firms invest more out of their own price shocks, while the peer effect is stronger for unconstrained firms; and we find significant peer effects within groups of small and large firms, respectively. Firms finance additional investment from peer real estate shocks using cash reserves. Overall, we document a new channel through which real estate is an economically significant determinant of corporate investment.
Optimization of wheat flour by product films: A technological and sustainable approach for bio‐based packaging material
Authors: Peron‐Schlosser Bianca , Carpiné Danielle , Matos Jorge Regina Maria , Rigon Spier Michele 
Published: September 2021

AbstractThis study aimed to evaluate the feasibility of the production of sustainable and biodegradable packages made from a little‐explored by product of wheat‐milling, the glue flour (GF). Films were produced by the casting method and the effect of the incorporation of glycerol, sorbitol, and GF in the properties of the films was investigated following the central composite rotational design (CCRD) approach. The results have been statistically analyzed by the response surface methodology and the desirability function. Due to the rich composition in amylaceous reserve (64.81%; 26% of amylose content), considerable protein content (11.23%), and fibers (8.28%), the GF proved to be suitable for use as a matrix in biopolymer films. All the properties were mainly influenced by the plasticizer type and GF concentration. Film plasticized with glycerol (run 13) was more flexible, had higher moisture (28.39%) content, and was more adhesive than the formulation made with sorbitol (run 11). Film elongation (ELO) ranged from 25.84% to 56.71%, and tensile strength (TS) from 0.10 to 2.8 MPa. The optimized process conditions were 8% for Cf, 0% for Cg, and 4% for Cs. Under these conditions, the films presented low moisture (12.1%), moderate solubility (35.5%) and TS (1.64 MPa), and high ELO (72.06%). This study showed that GF is a promising source for the development of biodegradable films.Practical ApplicationFilms made from a by product of wheat flour (glue flour) have technological potential to be used as packaging for food products. The valorization of a by product of the agribusiness without pre‐treatment for the production of biodegradable films was made possible. The study by casting technique is a previous for scale‐up production.
Deciphering the molecular signal from past and alive bacterial communities in aquatic sedimentary archives
Authors: Pearman John K. , Biessy Laura , Howarth Jamie D. , Vandergoes Marcus J. , Rees Andrew , Wood Susanna A. 
Published: September 2021

AbstractLake sediments accumulate information on biological communities thus acting as natural archives. Traditionally paleolimnology has focussed on fossilized remains of organisms, however, many organisms do not leave fossil evidence, meaning major ecosystem components are missing from environmental reconstructions. Many paleolimnology studies now incorporate molecular methods, including investigating microbial communities using environmental DNA (eDNA), but there is uncertainty about the contribution of living organisms to molecular inventories. In the present study, we obtained DNA and RNA inventories from sediment spanning 700 years to investigate the contribution of past and active communities to the molecular signal from sedimentary archives. Additionally, a droplet digital PCR (ddPCR) targeting the 16S ribosomal RNA (16S rRNA) gene of the photosynthetic cyanobacterial genera Microcystis was used to explore if RNA signals were from legacy RNA. We posit that the RNA signal is a mixture of legacy RNA, dormant cells, living bacteria and modern‐day trace level contaminants that were introduced during sampling and preferentially amplified. The presence of legacy RNA was confirmed by the detection of Microcystis in sediments aged to ~200 years ago. Recent comparisons between 16S rRNA gene metabarcoding and traditional paleo proxies showed that past changes in bacterial communities can be reconstructed from sedimentary archives. The recovery of RNA in the present study has provided new insights into the origin of these signals. However, caution is required during analysis and interpretation of 16S rRNA gene metabarcoding data especially in recent sediments were there are potentially active bacteria.
miR‐24 and its target gene Prdx6 regulate viability and senescence of myogenic progenitors during aging
Authors: Soriano‐Arroquia Ana , Gostage John , Xia Qin , Bardell David , McCormick Rachel , McCloskey Eugene , Bellantuono Ilaria , Clegg Peter , McDonagh Brian , Goljanek‐Whysall Katarzyna 
Published: September 2021

AbstractSatellite cell‐dependent skeletal muscle regeneration declines during aging. Disruptions within the satellite cells and their niche, together with alterations in the myofibrillar environment, contribute to age‐related dysfunction and defective muscle regeneration. In this study, we demonstrated an age‐related decline in satellite cell viability and myogenic potential and an increase in ROS and cellular senescence. We detected a transient upregulation of miR‐24 in regenerating muscle from adult mice and downregulation of miR‐24 during muscle regeneration in old mice. FACS‐sorted satellite cells were characterized by decreased levels of miR‐24 and a concomitant increase in expression of its target: Prdx6. Using GFP reporter constructs, we demonstrated that miR‐24 directly binds to its predicted site within Prdx6 mRNA. Subtle changes in Prdx6 levels following changes in miR‐24 expression indicate miR‐24 plays a role in fine‐tuning Prdx6 expression. Changes in miR‐24 and Prdx6 levels were associated with altered mitochondrial ROS generation, increase in the DNA damage marker: phosphorylated‐H2Ax and changes in viability, senescence, and myogenic potential of myogenic progenitors from mice and humans. The effects of miR‐24 were more pronounced in myogenic progenitors from old mice, suggesting a context‐dependent role of miR‐24 in these cells, with miR‐24 downregulation likely a part of a compensatory response to declining satellite cell function during aging. We propose that downregulation of miR‐24 and subsequent upregulation of Prdx6 in muscle of old mice following injury are an adaptive response to aging, to maintain satellite cell viability and myogenic potential through regulation of mitochondrial ROS and DNA damage pathways.
Mother’s curse on conservation: assessing the role of mtDNA in sex‐specific survival differences in ex‐situ breeding programs
Authors: Leeflang H. L. , Van Dongen S. , Helsen P. 
Published: September 2021

AbstractFor captive breeding to be an effective conservation tool, population fitness needs to be guaranteed according to the latest insights. Preserving genetic diversity has been a major pillar in conservation breeding, as it is a proxy for long‐term population viability. Small differences on the DNA level can impact an individual’s overall fitness and when situated on the mitochondrial genome might more specifically affect the process of aging and fertility. In general, mitochondrial DNA is transmitted via the mother. In the process of natural selection, variants beneficial for female fitness will be selected for whereas male‐harming variants that are neutral or beneficial in females will never be selected against. This biased selective sieve results in the accumulation of male‐harming mutations in the mitochondrial DNA, a process labelled “mother's curse”. Regardless of the susceptibility of zoo populations to “mother’s curse”, mitochondrial‐induced fitness effects have remained unstudied within captive breeding programs. While current conservation breeding strategies focus on retaining nuclear diversity, studies that specifically concentrate on aberrant extra‐nuclear genetic processes might improve breeding practices. Here, we provide a framework and empirical evidence for the presence of mtDNA‐induced sex‐specific differences starting from readily available population information. We analyzed whether an individual’s mitochondrial background partly affects survival in a sex‐specific manner using studbook data from captive populations representing 16 species. Our results indicate male survival is affected in five maternal lineages on pre‐ and postnatal level. Additionally, we describe the overall beneficial effects some maternal lineages have over others in terms of survival. These results are of interest in the debate on the maintenance of healthy captive populations and how to further improve safeguarding their genetic diversity for both ex‐situ and in‐situ conservation.
Automatic wide complex tachycardia differentiation using mathematically synthesized vectorcardiogram signals
Authors: Kashou Anthony H. , LoCoco Sarah , McGill Trevon D. , Evenson Christopher M. , Deshmukh Abhishek J. , Hodge David O. , Cooper Daniel H. , Sodhi Sandeep S. , Cuculich Phillip S. , Asirvatham Samuel J. , Noseworthy Peter A. , DeSimone Christopher V. , May Adam M. 
Published: September 2021

AbstractBackgroundAutomated wide complex tachycardia (WCT) differentiation into ventricular tachycardia (VT) and supraventricular wide complex tachycardia (SWCT) may be accomplished using novel calculations that quantify the extent of mean electrical vector changes between the WCT and baseline electrocardiogram (ECG). At present, it is unknown whether quantifying mean electrical vector changes within three orthogonal vectorcardiogram (VCG) leads (X, Y, and Z leads) can improve automated VT and SWCT classification.MethodsA derivation cohort of paired WCT and baseline ECGs was used to derive five logistic regression models: (i) one novel WCT differentiation model (i.e., VCG Model), (ii) three previously developed WCT differentiation models (i.e., WCT Formula, VT Prediction Model, and WCT Formula II), and (iii) one “all‐inclusive” model (i.e., Hybrid Model). A separate validation cohort of paired WCT and baseline ECGs was used to trial and compare each model's performance.ResultsThe VCG Model, composed of WCT QRS duration, baseline QRS duration, absolute change in QRS duration, X‐lead QRS amplitude change, Y‐lead QRS amplitude change, and Z‐lead QRS amplitude change, demonstrated effective WCT differentiation (area under the curve [AUC] 0.94) for the derivation cohort. For the validation cohort, the diagnostic performance of the VCG Model (AUC 0.94) was similar to that achieved by the WCT Formula (AUC 0.95), VT Prediction Model (AUC 0.91), WCT Formula II (AUC 0.94), and Hybrid Model (AUC 0.95).ConclusionCustom calculations derived from mathematically synthesized VCG signals may be used to formulate an effective means to differentiate WCTs automatically.