bluuebunny/crossref_metadata_2025_split huggingface dataset:
Displaced Orbital Fractures with Concurrent Orbital Compartment Syndrome: A Case-Based Systematic Review
Authors: Zogheib Serge , Sukkarieh Georges , Mjaess Georges , Zeid Samer Abou 
Published: December 2021

AbstractOrbital compartment syndrome (OCS) is an emergency that complicates intra-orbital, retrobulbar hemorrhage in most cases. Bony orbital decompression is an effective treatment for OCS, and displaced orbital fractures are protective. Nevertheless, in rare cases, OCS occurs despite a displaced orbital fracture. The aim of the current review is to present its pathophysiology and management based on what is published in the medical literature, and our center's experience. A systematic review of literature was conducted through PubMed, Medline, Embase, and Cochrane from inception through February 2021. The following search query was used: “orbital fracture” and “trauma” and “orbital compartment syndrome.” Studies tackling the pathophysiology and management of concurrent displaced orbital fracture with OCS were included and a cohort of patients was constituted. A cohort of 18 cases reported in the literature were included (49.3 ± 30.6 years, 50% M). Given that OCS occurs with or without orbital fracture, pathophysiology of OCS is mostly explained by the division of the orbital fat into many compartments, due to the presence of Koorneef's fibrous septa. Management of OCS in such circumstances consisted of inferior-lateral canthotomy and cantholysis in 50% of cases, subperiosteal drainage with myringotomy in 22.2% of cases, subperiosteal drainage in 16.7% of cases, and complete lateral cantholysis in 16.7% of cases. Two cases who presented to our tertiary care center were also added to this review. Physicians should be aware that OCS can occur even with displaced fractures of the orbital cavity. When clinical suspicion is present, an emergent management is needed.
Genetic Diagnostic Strategies and Counseling for Families Affected by Congenital Diaphragmatic Hernia
Authors: Bendixen Charlotte , Brosens Erwin , Chung Wendy Kay 
Published: December 2021

AbstractCongenital diaphragmatic hernia (CDH) is a relatively common and severe birth defect with variable clinical outcome and associated malformations in up to 60% of patients. Mortality and morbidity remain high despite advances in pre-, intra-, and postnatal management. We review the current literature and give an overview about the genetics of CDH to provide guidelines for clinicians with respect to genetic diagnostics and counseling for families. Until recently, the common practice was (molecular) karyotyping or chromosome microarray if the CDH diagnosis is made prenatally with a 10% diagnostic yield. Undiagnosed patients can be reflexed to trio exome/genome sequencing with an additional diagnostic yield of 10 to 20%. Even with a genetic diagnosis, there can be a range of clinical outcomes. All families with a child with CDH with or without additional malformations should be offered genetic counseling and testing in a family-based trio approach.
Genetic Counseling and Diagnostics in Anorectal Malformation
Authors: Marcelis Carlo , Dworschak Gabriel , de Blaauw Ivo , van Rooij Iris A.L.M. 
Published: December 2021

AbstractAnorectal malformation (ARM) is a relatively frequently occurring congenital anomaly of hindgut development with a prevalence of 1 in 3,000 live births. ARM may present as an isolated anomaly, but it can also be associated with other anomalies, sometimes as part of a recognizable syndrome. After birth, much medical attention is given to the treatment and restoring of bowel function in children with ARM. Effort should also be given to studying the etiology of the ARM in these patients. This information is important to both the medical community and the family, because it can help guide treatment and provides information on the long-term prognosis of the patient and recurrence risk in the family.In this article, we will review the current knowledge on the (genetic) etiology of (syndromic) ARM and provide guidelines for (family) history taking and clinical and genetic studies of ARM patients and their families, which is needed to study the causal factors in an ARM patient and for genetic counseling of the families.
Headache in Children and Adolescents: The Association between Screen Time and Headache within a Clinical Headache Population
Authors: Lund Josefine , Berring-Uldum Amalie , Colak Merve , Debes Nanette Marinette Monique 
Published: December 2021

Abstract
Background More than half of children and adolescents have experienced headache within the last 3 months. Several risk factors for headache have been identified, including obesity and lack of sleep. The association between screen time and headache in children and adolescents is sparsely investigated. The aim of this study was to assess this association and evaluate if it varied according to headache diagnosis.
Method This cross-sectional study was performed at the tertiary pediatric outpatient clinic for headache at Herlev University Hospital. A total of 139 participants who answered a questionnaire on lifestyle factors and their daily living were included. Diagnoses of migraine and tension-type headache (TTH) were made according to the International Classification of Headache Disorders-3. Children with both migraine and TTH were allocated to a mixed headache group. We differentiated between total, leisure, and school-related screen time.
Results The mean age was 13.20 ± 3.38 years and 53.2% were girls. Note that 25.2% were diagnosed with migraine without aura, 23.0% migraine with aura, 28.1% TTH, 15.8% mixed headache, and 7.9% had an unclassified headache diagnosis at the time of inclusion. There was no statistically significant difference in screen time across the five headache groups. An association between screen time and headache frequency was found in children with migraine with aura.
Conclusion In this study, we investigated the association between screen time and headache in children and adolescents. More screen time was associated with more frequent headaches in children with migraine with aura. Future prospective studies are needed to determine the causality of this association.
On-the-fly adiabatically switched semiclassical initial value representation molecular dynamics for vibrational spectroscopy of biomolecules
Authors: Botti Giacomo , Ceotto Michele , Conte Riccardo 
Published: December 2021

Semiclassical (SC) vibrational spectroscopy is a technique capable of reproducing quantum effects (such as zero-point energies, quantum resonances, and anharmonic overtones) from classical dynamics runs even in the case of very large dimensional systems. In a previous study [Conte et al. J. Chem. Phys. 151, 214107 (2019)], a preliminary sampling based on adiabatic switching has been shown to be able to improve the precision and accuracy of semiclassical results for challenging model potentials and small molecular systems. In this paper, we investigate the possibility to extend the technique to larger (bio)molecular systems whose dynamics must be integrated by means of ab initio “on-the-fly” calculations. After some preliminary tests on small molecules, we obtain the vibrational frequencies of glycine improving on pre-existing SC calculations. Finally, the new approach is applied to 17-atom proline, an amino acid characterized by a strong intramolecular hydrogen bond.
Neural circuit mechanisms of sensorimotor disability in cancer treatment
Authors: Housley Stephen N. , Nardelli Paul , Rotterman Travis M. , Cope Timothy C. 
Published: December 2021

SignificanceSevere and persistent disability often undermines the life-saving benefits of cancer treatment. Pain and fatigue, together with sensory, motor, and cognitive disorders, are chief among the constellation of side effects that occur with the platinum-based anticancer agents used in a majority of cancer treatments worldwide. These disabilities remain clinically unmitigated and empirically unexplained as research concentrates on peripheral degeneration of sensory neurons while understating the possible involvement of neural processes within the central nervous system. The present findings demonstrate functional defects in the fundamental properties of information processing localized within the central nervous system. We conclude that long-lasting sensorimotor and possibly other disabilities induced by cancer treatment result from independent neural defects compounded across both peripheral and central nervous systems.
Structure-based identification of sensor species for anticipating critical transitions
Authors: Aparicio Andrea , Velasco-Hernández Jorge X. , Moog Claude H. , Liu Yang-Yu , Angulo Marco Tulio 
Published: December 2021

Significance
Ecological systems can undergo abrupt and often catastrophic changes known as critical transitions. These critical transitions can be preceded by early warnings that are useful to anticipate them. But anticipating critical transitions in systems with many species is challenging because the early warnings can be absent in some species. Here, we leverage the mathematical formalism of “structural observability of dynamical systems” to address this fundamental issue. In mutualistic ecological systems, we show that “sensor species” that early anticipate a critical transition can be identified by knowing only the structure of plant–animal interactions.
MEKK3–TGFβ crosstalk regulates inward arterial remodeling
Authors: Deng Hanqiang , Xu Yanying , Hu Xiaoyue , Zhuang Zhen W. , Chang Yuzhou , Wang Yewei , Ntokou Aglaia , Schwartz Martin A. , Su Bing , Simons Michael 
Published: December 2021

Significance
Inward remodeling of arteries to reduce lumen diameter is a major factor in disease progression and morbidity in multiple vascular diseases, including hypertension and atherosclerosis. However, molecular mechanisms controlling inward arterial remodeling remain largely undefined. In this study, we identify endothelial MEKK3 as an unexpected regulator of inward remodeling via inhibition of TGFβ-Smad2/3 signaling. Genetic deletion of MEKK3 in adult endothelium results in induction of TGFβ-Smad2/3 signaling, endothelial-to-mesenchymal transition, and inward remodeling in both pulmonary and arterial circuits. The latter process results in pulmonary and systemic hypertension and accelerates atherosclerosis. These results provide a basis for understanding the inward artery remodeling that leads to reduced blood flow to affected tissues and exacerbates hypertension in vascular disease.
Low-energy electron holography imaging of conformational variability of single-antibody molecules from electrospray ion beam deposition
Authors: Ochner Hannah , Szilagyi Sven , Abb Sabine , Gault Joseph , Robinson Carol V. , Malavolti Luigi , Rauschenbach Stephan , Kern Klaus 
Published: December 2021

Significance
Molecular imaging at the single-molecule level of large and flexible proteins such as monoclonal IgG antibodies is possible by low-energy electron holography after chemically selective sample preparation by native electrospray ion beam deposition (ES-IBD) from native solution conditions. The single-molecule nature of the measurement allows the mapping of the structural variability of the molecules that originates from their intrinsic flexibility and from different adsorption geometries. Additionally, we can distinguish gas-phase–related conformations and conformations induced by the landing of the molecules on the surface. Our results underpin the relation between the gas-phase structure of protein ions created by native electrospray ionization (ESI) and the native protein structure and are of relevance for structural biology applications in the gas phase.
El españolismo lingüístico en el alumnado madrileño de Bachillerato
Authors: Pinto Pajares Daniel 
Published: December 2021

AbstractaEn este trabajo investigamos la ideología del españolismo lingüístico en una muestra representativa del alumnado de Bachillerato del municipio madrileño de Fuenlabrada. Mediante una técnica cuantitativa basada en cuestionarios anónimos, extraemos y analizamos las percepciones que a este grupo poblacional le sugiere la diversidad lingüística de España. Las personas participantes han asignado propiedades extralingüísticas al gallego, euskera, catalán y castellano como si de características inherentes a las lenguas se tratase. Asimismo, se han presentado estas lenguas para evaluarlas desde una perspectiva sociolingüística, de manera que se detectan diferencias sustanciales entre las lenguas en diferentes dominios sociales, así como prejuicios hacia los hablantes de cada una de ellas. Bajo esta carga valorativa se encierran diferentes premisas propias de la ideología del nacionalismo lingüístico español, que, a través de un discurso supremacista, emplaza al castellano en una posición preferente con respecto a otras lenguas de España y presenta a estas como lenguas menos aptas para la comunicación y como obstáculos para el desarrollo económico.
Estrategias de cortesía y valoraciones negativas en el comercio electrónico
Authors: Peng Shuo , Moreno Carrero Carlos Antonio 
Published: December 2021

ResumenLas valoraciones negativas escritas por los clientes de productos y servicios adquiridos a través de Internet se han convertido en una poderosa herramienta a favor del consumidor. Gracias a esta, dichos consumidores expresan, generalmente, sus quejas ante la falta de adecuación entre el producto descrito y el producto finalmente obtenido, y que revierte en la imagen de la empresa que las recibe. En el marco de la cortesía lingüística y basándonos en un corpus compuesto por seiscientas opiniones negativas recogidas en la página web de Amazon, el presente trabajo analiza contrastivamente las estrategias de cortesía empleadas en las valoraciones negativas de consumidores chinos y españoles acentuando una perspectiva sociocultural y combinando una metodología tanto cualitativa como cuantitativa. El estudio revelará cómo las estrategias de cortesía chinas están orientadas hacia la construcción de una imagen positiva mientras que las españolas se encaminan a una imagen negativa. También se desprende de la investigación un análisis de algunos cambios en los modelos de cortesía verbal con respecto a la cortesía convencional.
Hamiltonian analysis and positivity of a new massive spin-2 model
Authors: dos Santos Alessandro L R , Dalmazi Denis , de Paula Wayne 
Published: December 2021

Abstract
Recently a new model has been proposed to describe free massive spin-2 particles in D dimensions in terms of a non symmetric rank-2 tensor e

μν
and a mixed symmetry tensor B

μ[αβ]. The model is invariant under linearized diffeomorphisms without Stueckelberg fields. It resembles a spin-2 version of the topologically massive spin-1 BF model (Cremmer–Scherk model). Here we apply the Dirac–Bergmann procedure in order to identify all Hamiltonian constraints and perform a complete counting of degrees of freedom. In D = 3 + 1 we find 5 degrees of freedom corresponding to helicities ±2, ±1, 0 as expected. The positivity of the reduced Hamiltonian is proved by using spin projection operators. We have also proposed a parent action that establishes the duality between the Fierz–Pauli and the new model. The equivalence between gauge invariant correlation functions of both theories is demonstrated.
Dynamical effective field model for interacting ferrofluids: II. The proper relaxation time and effects of dynamic correlations
Authors: Fang Angbo 
Published: December 2021

Abstract
The recently proposed dynamical effective field model (DEFM) is quantitatively accurate for ferrofluid dynamics. It is derived in paper I within the framework of dynamical density functional theory (DDFT) along with a phenomenological description of nonadiabatic effects. However, it remains to clarify how the characteristic rotational relaxation time of a dressed particle, denoted by τ

r
, is quantitatively related to that of a bare particle, denoted by

τ

r

0

. By building macro-micro connections via two different routes, I reveal that under some gentle assumptions τ

r
can be identified with the mean time characterizing long-time rotational self-diffusion. I further introduce two simple but useful integrated correlation factors, describing the effects of quasi-static (adiabatic) and dynamic (nonadiabatic) inter-particle correlations, respectively. In terms of both the dynamic magnetic susceptibility is expressed in an illuminating and elegant form. Remarkably, it shows that the macro-micro connection is established via two successive steps: a dynamical coarse-graining with nonadiabatic effects accounted for by the dynamic factor, followed by equilibrium ensemble averaging captured by the static factor. By analyzing data from Brownian dynamics simulations on monodisperse interacting ferrofluids, I find

τ

r

/

τ

r

0

is, somehow unexpectedly, insensitive to changes of particle volume fraction. A physical picture is proposed to explain it. Furthermore, an empirical formula is proposed to characterize the dependence of

τ

r

/

τ

r

0

on dipole-dipole interaction strength. The DEFM supplemented with this formula leads to parameter-free predictions in good agreement with results from Brownian dynamics simulations. The theoretical developments presented in this paper may have important consequences to studies of ferrofluid dynamics in particular and other systems modeled by DDFTs in general.
Electronic structure, phonons and optical properties of baryte type scintillators TlXO4 (X = Cl, Br)
Authors: Mukherjee Supratik , T Aiswarya , Mondal Subrata , Vaitheeswaran G 
Published: December 2021

Abstract
This article thoroughly addresses the structural, mechanical, vibrational, electronic band structure and the optical properties of the unexplored thallous perchlorate and perbromate from ab initio calculations. The zone centered vibrational phonon frequencies shows, there is a blue shift in the mid and high frequency range from Cl → Br due to change in mass and force constant with respect to oxygen atom. From the band structure it is clear that the top of the valence band is due to thallium s states, whereas the bottom of the conduction band is due to halogen s and oxygen p states, showing similar magnitude of dispersion and exhibits a charge transfer character. These characteristics and the band gap obtained are consistent with that of a favourable scintillators. Our findings deliver directions for the design of efficient TlXO4 based scintillators with high performance which are desirable for distinct applications such as medical imaging, high energy physics experiments, nuclear security.
Trimetallic metal-organic frameworks (Fe, Co, Ni-MOF) derived as efficient electrochemical determination for ultra-micro imidacloprid in vegetables
Authors: Shu Hui , Lai Tingrun , Ren Jie , Cui Xiuxiu , Tian Xu , Yang Zhichao , Xiao Xuechun , Wang Yude 
Published: December 2021

Abstract
The excessive use of imidacloprid in agricultural production leads to a large number of residues that seriously threaten human health. Therefore, the detection of imidacloprid has become very important. But how to quantitatively detect imidacloprid at ultra-low levels is the main challenges. In this work, trimetallic metal-organic frameworks Fe, Co, Ni-MOF (FCN-MOF) is in situ prepared on nickel foam (NF) and then used to make an electrochemical sensor in the detection of imidacloprid. FCN-MOF exhibits the characteristics of ultra-micro concentration detection for imidacloprid with high specific surface area and rich active metal centers. The high conductivity and 3D skeleton structure of the NF electrode enhance the contact site with imidacloprid and promote the transmission of electrons efficiently. All results show that the prepared electrochemical sensor has the advantages of ultra-low detection limits (0.1 pM), wide linear detection ranges (1–5 × 107 pM) and good sensitivity (132.91 μA pM‒1 cm‒2), as well as good reproducibility, excellent anti-interference ability, and fantastic stability. Meanwhile, the electrochemical sensor is used to determine imidacloprid in lettuce, tomato, and cucumber samples with excellent recovery (90%–102.7%). The novel electrochemical sensor is successfully applied to the ultra-micro detection of imidacloprid in vegetables, which provides a new way for the efficient monitoring of imidacloprid in agriculture.
Pseudo single domain NiZn-γFe2O3 colloidal superparamagnetic nanoparticles for MRI-guided hyperthermia application
Authors: Kim Ji-Wook , Wang Jie , Kim Hyungsub , Bae Seongtae 
Published: December 2021

Abstract
Magnetic resonance imaging (MRI)-guided magnetic nanofluid hyperthermia (MNFH) is highly desirable in cancer treatment because it can allow for diagnosis, therapeutics, and prognosis simultaneously. However, the application of currently developed iron-oxide based superparamagnetic nanoparticles (IOSPNPs) for an MRI-guided MNFH agent is technically limited by the low AC heat induction power at the physiologically tolerable range of AC magnetic field (H
AC,safe), and the low transverse r
2-relaxivity responsible for the insufficient heating of cancers, and the low resolution of contrast imaging, respectively. Here, pseudo single domain colloidal Ni
x
Zn1−x
–γFe2O3 (x = 0.6) superparamagnetic nanoparticle (NiZn-γFe2O3 PSD-SPNP) physically and theoretically designed at the H
AC,safe, specifically by the applied frequency, is proposed for a highly enhanced MRI-guided MNFH agent application. The NiZn-γFe2O3 PSD-SPNP showed the superparamagnetic characteristics, significantly enhanced AC heat induction performance (ILP = 6.3 nHm2 kg−1), highly improved saturation magnetization (M

s
= 97 emu g−1 Fe, 3.55 × 105 A m−1) and r
2-relaxivity (r
2 = 396 mM−1 s−1) that are desirable for highly efficient MRI-guided MNFH agent applications. According to the analyzed results, the remarkably enhanced effective relaxation time constant and its dependent out-of-phase magnetic susceptibility, as well as the DC/AC magnetic softness optimized by the PSD-SPNP at the H
AC,safe were revealed as the main physical reason for the significance. All the fundamental in vitro and in vivo experimental results demonstrated that the physically designed NiZn-γFe2O3 PSD-SPNP is bio-technically feasible for a highly efficient MRI-guided MNFH agent for future cancer nanomedicine.
Nanoscale engineering of ring-mounted nanostructure around AAO nanopores for highly sensitive and reliable SERS substrates
Authors: Dong Jun , Wang Yan , Wang Qianying , Cao Yi , Han Qingyan , Gao Wei , Wang Yongkai , Qi Jianxia , Sun Mengtao 
Published: December 2021

Abstract
Surface-enhanced Raman scattering (SERS) is recognized as one of the most favored techniques for enhancing Raman signals. The morphology of the SERS substrate profoundly affects molecular Raman spectra. This study aimed to construct a ring-mounted nanostructured substrate via liquid–liquid two-phase self-assembly incorporated with anodic aluminum oxide (AAO) membrane transfer techniques. High-density nanoparticles (NPs) assembled on AAO membranes were ascribed to reduce the diameters of the nanopores, with Au–Ag alloy NPs to regulate the dielectric constant so as to reveal the local surface plasmon resonance tunability. SERS engineered in this way allowed for the fabrication of a ring-mounted nanostructured substrate where the distribution density of NPs and dielectric constant could be independently fine-tuned. High SERS activity of the substrate was revealed by detecting the enhanced factor of crystal violet and rhodamine 6G molecules, which was up to 1.56 × 106. Moreover, SERS of thiram target molecules confirmed the supersensitivity and repeatability of the substrate as a practical application. The results of this study manifested a low-cost but high-efficiency ring-mounted nanostructured SERS substrate that might be suitable in many fields, including biosensing, medical research, environmental monitoring, and optoelectronics.