bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges and opportunities in soil science: Learning from soils, learning from nature
Authors: Macías Felipe 
Published: September 2021

As part of the celebration of 2015 as the International Year of Soils, a review of the current status of soil science is presented, in particular on the future challenges of this discipline, such as the fight against hunger, the improvement of quality of life, and the need for increasing scientific understanding of our environment. The most recent contributions of soil science offering interesting prospects are also presented.
Perkembangan Pendidikan Terbuka Dan Jarak Jauh Di Indonesia
Authors: Rahmi Rivalina Sudirman Siahaan dan 
Published: September 2021

Perkembangan Pendidikan Terbuka dan Jarak Jauh (PTJJ) dapat dilihat dari 2 segi, yaitu (1) kelembagaan atau organisasi yang berkiprah di bidang PTJJ, dan (2) program PTJJ yang diterapkan/ diselenggarakan oleh lembaga/organisasi pendidikan. Dari segi kelembagaan/organisasi, semakin bertambah jumlah lembaga/organisasi yang berkiprah di bidang PTJJ, seperti antara lain: Sekolah Menengah Pertama Terbuka (SMP Terbuka), Sekolah Menengah Atas Terbuka (SMA Terbuka), Universitas Terbuka (UT), perguruan tinggi negeri konvensional yang sekaligus juga menyelenggarakan PTJJ ( dual modes), Jaringan Sistem Belajar Jarak
Jauh Indonesia (Jaringan Sistem BJJI) atau Indonesian Distance Learning Network (IDLN), dan SEAMEO Regional Open Learning Center (SEAMOLEC). Dari segi program PTJJ yang diterapkan/diselenggarakan, PTJJ diawali dari pemanfaatan bahan belajar mandiri tercetak (modul) dengan menggunakan jasa layanan pos sampai dengan pemanfaatan kemajuan teknologi Informasi dan komunikasi (TIK), seperti pemanfaatan media siaran (radio/televisi), media rekaman (audio, CD, VCD), media proyeksi (film bingkai suara, film 16mm, powerpoint), dan media jaringan (internet). Penyelenggaraan kegiatan belajar tutorial PTJJ juga mengalami
perkembangan, dimulai dari yang bersifat tatap muka sampai dengan tutorial yang menggunakan TIK. Pengelolaan PTJJ juga terus mengalami perkembangan, dimulai dari inisiatif lembaga atau organisasi yang bersifat individual sampai dengan pengelolaan yang dilakukan secara kemitraan melalui konsorsium.
Pengaruh Model Pembelajaran Sains Teknologi Masyarakat (STM) Terhadap Kemampuan Berpikir Kreatif Dan Self Regulation
Authors: Aulia Novitasari  , Jatmiko Agus , Elen Fahmi 
Published: September 2021

Kemampuan berpikir kreatif merupakan kemampuan pembelajaran abad 21 yang harus dimiliki peserta didik, kemampuan ini diperlukan untuk menemukan ide – ide baru yang dapat digunakan untuk memecahkan masalah dalam dunia nyata, proses penemuan ide-ide berkaitan erat dengan self regulation. Model Sains Teknologi Masyarakat adalah model pembelajaran yang bertujuan untuk mempersiapkan siswa untuk mengamalkan nilai sains, menerapkan pengetahuan ilmiah dan memecahkan masalah di lingkungan masyarakat, dengan ide yang tengah terjadi di masyarakat sebagai topik dalam pembelajaran, model ini diharapkan dapat meningkatkan kemampuan berpikir kreatif dan self regulation. Penelitian ini bertujuan untuk melihat pengaruh model Sains Teknologi Masyarakat terhadap kemampuan berpikir kreatif dan self regulation. Jenis penelitian ini adalah kuantitatif dengan metode Quasi Eksperimen, desain penelitian Posttest-Only Control Group Design. Populasi dalam penelitian ini adalah seluruh kelas VIII SMPN 1 Sumberejo, diperoleh sampel dengan cluster random sampling yaitu kelas VIII A sebagai kelas eksperimen dan VIII B sebagai kelas kontrol. Berdasarkan analisis data menggunakan MANOVA, diperoleh hasil sig< 0,05 artinya model pebelajaran Sains Teknologi Masyarakat berpengaruh terhadap kemampuan berpikir kreatif dan self regulation peserta didik kelas VIII SMPN 1 Sumberejo
Therapeutic angiogenesis by stem cell: new hope for the ischemic limbs
Authors: Mohiuddin AKM , Anwar Raihan , Lewis Peter , Sadiq BA 
Published: September 2021

Critical limb ischemia in an intractable condition associated with high level of amputation, leading to low quality of life increase morbidity and mortality. It is often not treated by standard therapeutic modalities. Neoangiogenesis has been proposed as a novel method of treatment of such patients. Vascular Endothelial Growth Factor (VEGF) and Cytokine Fibroblast growth Factor (FGF1) have been shown to elicit neoangiogesis. Stem cells are progenitor cells which can differentiate in vivo into different type of cells. Collateral vessel formation after stem cell therapy. A case of 50 years old male, diabetic, hypertensive with dry gangrene of tip of left ring finger was treated with stem cell therapy after proper counseling. He received the therapy in the form of SVF (Stromal Vascular Fraction) from adipose tissue by local injection in the territory of the affected vessels. Following monitoring parameters were reported, improved wound status, local temperature change, oxygen saturation change in the ischemic zone. Outcome of stem cell therapy in this case including the rest pain disappeared at 14 days and the finger becomes warmed by 5°C in 3 weeks. The gangrenous area healed in 3 months. Amputation was averted. Angiogenesis is a complex process leading to new blood vessels formation. Mesenchymal stem cells (MSCs) are a type of adult stem cell which has an immunomodulatory effect. Stem cell therapy has been used to improve limb Vascularity. Stem Cells are likely to be an important modality to treat critical limb ischemia.
CBMJ 2019 July: Vol. 08 No. 02 P: 40-46
STUDENT'S RESPONSE TO SMART APPS CREATOR MEDIA BASED ON THE LOCAL WISDOM OF MANTINGAN MOSQUE JEPARA TO INCREASE THE UNDERSTANDING ON THE CONCEPT OF GEOMETRY IN ELEMENTARY SCHOOL
Authors: Latif Abdul , Utaminingsih Sri , Su’ad Su’ad 
Published: September 2021

The purpose of this research was to analyze students’ response to Smart Apps Creator (SAC) media based on the local wisdom of Mantingan Mosque Jepara to improve the understanding of the concept of geometry at grade VI of the elementary schools in Kecamatan Kembang, Kabupaten Jepara. This research was Research and Development (R&D) using the method by Sugiyono at level 4. This research was conducted in seven steps, namely: 1) potential and problems, 2) literature study and information collection, 3) product design, 4) design validation, 5) design revision, 6) product manufacture, and 7) limited trial. The subjects of this study were 52 grade VI students at SD N 4 Cepogo, SDN 1 Bucu, and SDN 2 Bucu, Kecamatan Kembang, Kabupaten Jepara. The product in this research and development was Smart Apps Creator (SAC) mathematics media based on the local wisdom of the Mantingan Mosque Jepara. data were collected through interviews, questionnaires, and documentation. Then, the data were analyzed by a combination analysis, namely qualitative descriptive analysis and conversion of quantitative to qualitative data. The score of the students’ responses was 3969 with a percentage of 93.4%; the average score was 4.67 with a very good category. The media could be used if it got a good score (3.40 < X 4.21) from the students response. Thus, it was concluded that Smart Apps Creator (SAC) media based on the local wisdom of the Mantingan Mosque Jepara was feasible to improve students’ understanding of the concept of geometry at Grade VI Elementary Schools in Kecamatan Kembang, Kabupaten Jepara.
Prolonged Cryopreservation Negatively Affects Embryo Transfer Outcomes Following the Elective Freeze-All Strategy: A Multicenter Retrospective Study
Authors: Zhang Xudong , Wu Shanshan , Hao Guimin , Wu Xueqing , Ren Haiqin , Zhang Yinfeng , Yang Aimin , Bi Xingyu , Bai Lina , Zhang Yunshan , Tan Jichun 
Published: September 2021

BackgroundWith the development of embryo freezing and warming technology, frozen-thawed embryo transfer (FET) has been widely utilized. However, studies investigating the association between cryopreservation duration and FET outcomes are limited and controversial, and previous studies did not conduct stratification analyses based on demographic or clinical characteristics.MethodsThis multicenter retrospective study included 17,826 women who underwent their first FET following the freeze-all strategy during the period from January 2014 to December 2018. Duration of cryopreservation was categorized into five groups: 3–8 weeks, 8–12 weeks, 12–26 weeks, 26–52 weeks, and &gt;52 weeks. Modified Poisson regression and multivariate logistic regression were used to assess the association between cryostorage time of vitrified embryos and transfer outcomes. Moreover, further stratification analyses were performed according to variables with p &lt;0.05 in multivariate models.ResultsIn this large multicenter study, we observed that storage duration was inversely associated with the possibility of pregnancy and live birth (p &lt;0.001), but not with the risk of ectopic pregnancy and miscarriage. Stratification analyses based on maternal age, the number of oocytes retrieved, and condition of embryo transferred indicated that the inverse correlation was significant in the subpopulation with characteristics: (1) less than 40 years old, (2) more than 3 oocytes retrieved, and (3) only high-quality blastocysts transferred.ConclusionThe results of this large, multicenter, retrospective study suggested that prolonged cryopreservation was inversely associated with the probability of pregnancy and live birth. Therefore, for patients who adopt a freeze-all strategy, early FET might achieve a better outcome.
Case Report: An Atypical Angelman Syndrome Case With Obesity and Fulfilled Autism Spectrum Disorder Identified by Microarray
Authors: Hnoonual Areerat , Kor-anantakul Phawin , Charalsawadi Chariyawan , Worachotekamjorn Juthamas , Limprasert Pornprot 
Published: September 2021

Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders which are etiologically heterogeneous. Chromosomal microarray is now recommended as the first-tier clinical diagnostic test for ASD. We performed chromosomal microarray in 16 Thai patients with ASD using an Illumina HumanCytoSNP-12 v2.1 array and found one case with uniparental disomy (UPD) of chromosome 15. Methylation-specific PCR showed abnormal methylation of the maternal SNRPN allele. Haplotype analysis revealed that the patient had received both chromosomes 15 from his father. These results were consistent with Angelman syndrome. However, his clinical features had no clinical significance for classic Angelman syndrome. He had first presented at the pediatric clinic with no speech, poor social interaction skills and repetitive behaviors consistent with ASD based on the DSM-IV criteria at 2 years of age and later confirmed by ADOS at 5 years of age. He was strikingly overweight but had no dysmorphic facies, seizures nor ataxia and was diagnosed as non-syndromic ASD, a diagnosis which was believed until at 10 years of age, his DNA was included for analysis in this current cohort study. Our findings suggest that ASD patients with unknown etiology should be considered for methylation-specific PCR testing for Angelman syndrome where chromosomal microarray is not available. In the study, we also review the clinical features of Angelman syndrome caused by UPD and the frequency of ASD in individuals with Angelman syndrome.
The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult Volunteers
Authors: Starkov Dmitrii , Vermorken Bernd , Van Dooren T. S. , Van Stiphout Lisa , Janssen Miranda , Pleshkov Maksim , Guinand Nils , Pérez Fornos Angelica , Van Rompaey Vincent , Kingma Herman , Van de Berg Raymond 
Published: September 2021

Objective: This study aimed to identify differences in vestibulo-ocular reflex gain (VOR gain) and saccadic response in the suppression head impulse paradigm (SHIMP) between predictable and less predictable head movements, in a group of healthy subjects. It was hypothesized that higher prediction could lead to a lower VOR gain, a shorter saccadic latency, and higher grouping of saccades.Methods: Sixty-two healthy subjects were tested using the video head impulse test and SHIMPs in four conditions: active and passive head movements for both inward and outward directions. VOR gain, latency of the first saccade, and the level of saccade grouping (PR-score) were compared among conditions. Inward and active head movements were considered to be more predictable than outward and passive head movements.Results: After validation, results of 57 tested subjects were analyzed. Mean VOR gain was significantly lower for inward passive compared with outward passive head impulses (p &lt; 0.001), and it was higher for active compared with passive head impulses (both inward and outward) (p ≤ 0.024). Mean latency of the first saccade was significantly shorter for inward active compared with inward passive (p ≤ 0.001) and for inward passive compared with outward passive head impulses (p = 0.012). Mean PR-score was only significantly higher in active outward than in active inward head impulses (p = 0.004).Conclusion: For SHIMP, a higher predictability in head movements lowered gain only in passive impulses and shortened latencies of compensatory saccades overall. For active impulses, gain calculation was affected by short-latency compensatory saccades, hindering reliable comparison with gains of passive impulses. Predictability did not substantially influence grouping of compensatory saccades.
LINC00346 Sponges miR-30c-2-3p to Promote the Development of Lung Adenocarcinoma by Targeting MYBL2 and Regulating CELL CYCLE Signaling Pathway
Authors: Xu Qian , Xu Zhenwu , Zhu Kai , Lin Jinlan , Ye Bo 
Published: September 2021

BackgroundLINC00346 has recently been reported to regulate the development of several cancer types, but its biological functions and underlying mechanisms in lung adenocarcinoma (LUAD) have not been elucidated. The purpose of this study was to investigate the molecular mechanism of LINC00346 in the progression of LUAD.MethodsBioinformatics was performed to find the target lncRNA, miRNA and mRNA, and the binding relationship between the target genes was verified by dual luciferase reporter gene and RIP assays. Fluorescence in situ hybridization was used to detect the location of LINC00346 in LUAD tissues. The expressions of LINC00346, miR-30c-2-3p and MYBL2 in each group were detected by qRT-PCR, and western blot was performed to detect expressions of MYBL2 and CELL CYCLE related proteins. Proliferation, metastasis, apoptosis and cell cycle of LUAD cells were detected by CCK-8, colony formation, Transwell and flow cytometry assays, respectively. Mouse xenograft models were established to further determine the effects of LINC00346 on LUAD tumor growth in vivo.ResultsLINC00346 was upregulated in LUAD tissues and cells and was mainly localized in the cytoplasm. Knockdown of LINC00346 inhibited tumor growth in vivo, proliferation, metastasis and cell cycle progression, while induced apoptosis. LINC00346 sponged miR-30c-2-3 by targeting MYBL2 and regulating CELL CYCLE signaling pathway. Inhibiting miR-30c-2-3p or overexpressing MYBL2 could reverse the inhibitory effect of LINC00346 knockdown on LUAD process.ConclusionsLINC00346 as a ceRNA played a carcinogenic role in the development of LUAD via miR-30c-2-3p/MYBL2 axis regulating the CELL CYCLE signaling pathway. The study generally elucidated the mechanism by which LINC00346 regulated the development of LUAD, providing new ideas for the diagnosis and treatment of LUAD guided by lncRNA.
Reconstruction of Complex Lateral Skull Base Defects After Oral Cancer Resection With Individualized Anterolateral Thigh Flap
Authors: Gong Zhaojian , Zhang Shanshan , Chen Chang , Zhi Yuan , Zi Moxin 
Published: September 2021

ObjectivesComplex lateral skull base defects resulting from advanced or recurrent oral cancer resection are continuously challenging reconstructive surgeons. This study aimed to use reconstructive methods for lateral skull base defects, explore their feasibility, and evaluate the efficacy of defect reconstruction using anterolateral thigh (ALT) flaps.Patients and MethodsWe performed a retrospective case series of 37 patients who underwent lateral skull base defect reconstruction using the ALT/anteromedial thigh (AMT) flap between March 2016 and May 2021 at the Second Xiangya Hospital. The design and harvest of the flaps, methods for defect reconstruction, and reconstructive efficacy are described.ResultsOf the 37 patients, 3 were women and 34 were men, with a mean age of 51.7 years. Among the defects, 26 were through-and-through defects and were reconstructed using ALT chimeric flaps, double ALT flaps, folded ALT flap, combined ALT chimeric flaps and AMT flaps, or combined ALT chimeric flaps and pectoralis major flaps; the large lateral skull base dead spaces were filled with muscle tissues or fatty tissues. Postoperatively, 38 of the 39 ALT/AMT flaps survived completely, and the remaining flap experienced partial necrosis. Venous compromise occurred in one patient who was salvaged after operative exploration. Oral and maxillofacial wound infections occurred in two patients, salivary fistula in three patients, and thigh wound effusion in three patients. The wounds healed gradually in all patients after repeated dressing changes. Thirty-three patients were followed up for approximately 3–60 months; their oral functions and appearance were acceptable, and thigh motor dysfunction was not observed.ConclusionsWith the convenient flap design and muscle flap harvest, large and individualized tissue supply, feasible combination with other flaps, effective reduction or avoidance of wound complications, and acceptable donor site morbidity, the ALT flap is an appropriate choice for complex lateral skull base defect reconstruction.
Probiotic VSL#3 Treatment Reduces Colonic Permeability and Abdominal Pain Symptoms in Patients With Irritable Bowel Syndrome
Authors: Boonma Prapaporn , Shapiro Jordan M. , Hollister Emily B. , Badu Shyam , Wu Qinglong , Weidler Erica M. , Abraham Bincy P. , Devaraj Sridevi , Luna Ruth Ann , Versalovic James , Heitkemper Margaret M. , Savidge Tor C. , Shulman Robert J. 
Published: September 2021

Background:Little is known regarding the clinical impact of treatment and treatment duration of probiotic VSL#3 on gut and microbiome function in irritable bowel syndrome (IBS). As part of a safety trial, we assessed the effect of VSL#3 treatment duration on abdominal pain, stooling, gut permeability, microbiome composition and function.Methods:Adults with IBS were randomized into an open label trial to receive the probiotic VSL#3 for 4 or 8 weeks. Adverse events, abdominal pain, and stooling patterns were recorded daily. Gut permeability, fecal bile acid levels, and microbiome composition were profiled at baseline and after treatment.Results:Fifteen subjects completed the trial (4-week:n= 8; 8-week:n= 7). Number of pain episodes decreased in both groups (P= 0.049 andP= 0.034; 4- vs. 8-week, respectively). Probiotic organisms contained in VSL#3 were detected in feces by whole shotgun metagenomic sequencing analysis and relative abundances ofStreptococcus thermophilus, Bifidobacterium animalis, Lactobacillus plantarum, andLactobacillus caseisubsp.paraccaseicorrelated significantly with improved abdominal pain symptoms and colonic permeability at study completion. Although abdominal pain correlated significantly with the detection of probiotic species at study completion, a composite view of gut microbiome structure showed no changes in community diversity or composition after VSL#3 treatment.Conclusions:Probiotic organisms identified in stool correlated significantly with improvement in colonic permeability and clinical symptoms, prompting future studies to investigate the mechanistic role of VSL#3 and colonic permeability in IBS pathophysiology in a larger randomized controlled trial.Clinical Trial Registration:www.clinicaltrials.gov, Identifier: NCT00971711.
Lifestyle Risk Factors and the Population Attributable Fractions for Overweight and Obesity in Chinese Students of Zhejiang Province
Authors: Gu Fang , Zhou Siliang , Lou Ke , Deng Rui , Li Xingxiu , Hu Jie , Dong Bin 
Published: September 2021

Objectives: To assess the relationship between modifiable lifestyle factors and risk of overweight/obesity in Chinese students, and to evaluate the predicting prevalence of overweight if the lifestyle risk factors were removed.Methods: A cross-sectional survey was conducted among 40,141 students in grade three and above (8–24yrs) in 2019 in Zhejiang Province, China. Physical examination was performed, and a self-administered questionnaire was used to collect lifestyle information, including dietary behavior, physical activity, TV watching, sleeping, smoking, drinking, and tooth-brushing habits. Logistic regression models were performed to assess the relationship between overweight/obesity and a series of lifestyle factors. Population attributable fractions (PAFs) were used to calculate the predicting prevalence of overweight/obesity if lifestyle risk factors were removed.Results: The prevalence of overweight/obesity of participants was 25.5% (male 32.3%, female 18.1%). Overweight/obesity were associated with adverse lifestyle factors, such as watch TV ≥1 h/day (OR = 1.14, 95% CI: 1.11–1.22), insufficient sleep (OR = 1.14, 95% CI: 1.11–1.22), and irregular toothbrushing habits (OR = 1.19, 95% CI: 1.01–1.39). Based on the calculated PAFs, the predicted prevalence of overweight/obesity would decline moderately if lifestyle factors were modified, with the magnitudes of decrease vary by sex, age and residence. Generally, a larger reduction was estimated if the sleeping time was increased and TV time was reduced, with the prevalence of overweight/obesity decreased by 1.1% (95% CI: 0.7, 1.5%) and 0.9% (95% CI: 0.6, 1.2%), respectively.Conclusions: Predicted prevalence of overweight/ obesity in Chinese students may decrease if modifiable lifestyle risk factors were removed. The attributable risk for obesity of lifestyle behaviors varied in age, sex and residence groups. The findings of this study may provide insights for planning and optimizing future obesity intervention endeavors.
Arterial Hypertension and Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia: A Systematic Review and Meta-Analysis
Authors: Mulas Olga , Caocci Giovanni , Mola Brunella , La Nasa Giorgio 
Published: September 2021

Background: Off-target effects in chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKIs) are associated with cardiovascular toxicity. Hypertension represents an important cardiovascular complication and, if not appropriately managed, can contribute to developing thrombotic events. Third-generation TKI ponatinib is associated with hypertension development, and its use is more restricted than in the past. Few data are reported for second-generation TKI, nilotinib, dasatinib, and bosutinib. The aim of this article was to evaluate with a systematic review and meta-analysis the real incidence of hypertension in CML patients treated with second- or third-generation TKI.Methods: The PubMed database, Web of Science, Scopus, and ClinicalTrials.gov were systematically searched for studies published between January 1, 2000, and January 30, 2021; the following terms were entered in the database queries: Cardiovascular, Chronic Myeloid Leukemia, CML, Tyrosine kinases inhibitor, TKI, and Hypertension. The study was carried out according to the Preferred Reporting Items for Systematic and Meta-Analyses (PRISMA) statement.Results: A pooled analysis of hypertension incidence was 10% for all new-generation TKI, with an even higher prevalence with ponatinib (17%). The comparison with the first-generation imatinib confirmed that nilotinib was associated with a significantly increased risk of hypertension (RR 2; 95% CI; 1.39-2.88, I2=0%, z=3.73, p=0.0002). The greatest risk was found with ponatinib (RR 9.21; 95% CI; 2.86-29.66, z=3.72, p=0.0002).Conclusion: Hypertension is a common cardiovascular complication in CML patients treated with second- or third-generation TKI.