bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mixed RuIIComplexes Containing Diseleno‐Ligand and α,β‐Diketones Donors with Anticancer Activity. Synthesis, Characterization, Electrochemical and DFT Studies
Authors: Hernández‐Ayala Luis Felipe , Novoa‐Ramírez Cynthia Sinaí , Reina Miguel , Ruiz‐Azuara Lena 
Published: November 2021

AbstractThis work presents the synthesis, characterization, electrochemical studies, DFT calculations and in vitro evaluation of antiproliferative activity in HeLa cells of four novel direct bonded ruthenium‐selenium compounds. The complexes are [Ru(BP3Se2)Cl(PPh3)]Cl(1)and mixed [Ru(BP3Se2)(O−O)(PPh3)]Cl (2 a,2 b,2 c) systems with diseleno‐ligandBP3Se2: 1,9‐bis(2‐pyridyl)‐3,7‐diselenanonane as a primary donor and O−O: α,β‐diketones as a secondary donors. In1,BP3Se2is linked in tetradentate N2Se2form while in mixed complexes, present a tridentate NSe2linkage. Diketone nature and electroactive groups has a fundamental role in the modulation of the electronic, steric and lipophilic properties as well as in its cytotoxic activity. Among the tested compounds,2 chas the best cytotoxic performance (IC50=2.8 μmol/L) even higher than metallodrug cisplatin. In this regard, cytotoxic activity is strongly determined by experimental redox potential (E0) and calculated molar volume (VM) of the compounds.
Borrowing Hydrogen and Acceptorless Dehydrogenative Coupling in the Multicomponent Synthesis of N‐Heterocycles: A Comparison between Base and Noble Metal Catalysis
Authors: Hofmann Natalie , Hultzsch Kai C. 
Published: November 2021

AbstractAcceptorless dehydrogenative coupling reactions (ADC) and hydrogen transfer strategies (HT) provide a powerful tool in the multicomponent formation of N‐heterocycles. A broad variety of complex products can be obtained starting from simple, cheap and commercially available reagents. The protocols are highly atom‐efficient, as water, dihydrogen, or in some cases hydrogen peroxide, are the only by‐products. Moreover, neither further reducing or oxidizing agents, nor external hydrogen are in general required. Especially base metal‐catalyzed strategies become ever more important. Therefore, in recent years, various different manganese, iron, cobalt, nickel and copper catalysts have been developed. This Minireview highlights the progress that has been made by using abundant metal complexes to promote multicomponent cyclizations for the formation of N‐heterocycles and compares their performance with available noble metal catalyst systems.
Geochemistry and zircon U–Pb dating of Early Jurassic syenogranite in the Kaoshan area, southern part of the Zhangguangcai Range, NE China, and tectonic implications
Authors: Ye Xiqing , Sun Liying , Xu Zhitao , Yan Donghan , Yang Qingfu , Zhu Daqing , Feng Jingqiao , Chen Linrong 
Published: November 2021

Early Jurassic Kaoshan medium‐ and fine‐grained syenogranites emplaced along the Yitong–Shulan Fault Zone in the southern part the Zhangguangcai Range, central Jilin Province, intruded Middle Triassic granitoids and Carboniferous‐Devonian intrusive rocks. They have medium‐ and fine‐grained textures and contain K‐feldspar, quartz, plagioclase, and biotite. They are peraluminous (A/CNK = 1.13–1.20) and have high values of SiO2 (74.60–75.82 wt%), total alkalis (Na2O + K2O = 8.28–9.18 wt%), light rare earth elements (20.89–56.14 ppm), large‐ion lithophile elements, and FeO/MgO = 2.78–5.93. In contrast, they feature low values of CaO (0.40–0.49 wt%), TiO2 (0.05–0.14 wt%), P2O5 (0.02–0.04 wt%), Sr (24.20–62.59 ppm), heavy rare earth elements (5.14–11.80 ppm), high‐field‐strength elements, and δEu (0.41–0.76), and the calculated zircon saturation temperatures (Tzr) range from 804 to 870°C, all of which are similar to the geochemical signatures of anorogenic A1‐type granites. Zircon U–Pb geochronology analyses from the medium‐ and fine‐grained syenogranites yield concordia ages of 193.18 ± 0.95 Ma (MSWD = 6.7, n = 18) and 190.29 ± 0.92 Ma (MSWD = 8.7, n = 17), respectively, and belong to the Early Jurassic Sinemurian stage. In situ Hf isotope analyses of dated zircons yield εHf(t) values ranging from +17.0 to +9.7 and Hf model ages (TDMC) of 225–614 Ma. Their whole‐rock (87Sr/86Sr)i (0.704740–0.704133) and εNd(t) values (+2.8 to +0.2) are similar to those of many coeval A2‐type granites in this region, and they form an A‐type granite assemblage. Consequently, the Kaoshan medium‐ and fine‐grained syenogranites were probably derived from partial melting of juvenile lower crust and might be related to the subduction of the Palaeo‐Pacific Plate.
Improving youth physical, mental and social health through physical activity: A Systematic literature review
Authors: Kemel Paul N. , Porter Joanne E. , Coombs Nicole 
Published: November 2021

AbstractBackgroundAcross various parts of the world there is an increasing trend in adolescent and young adult physical inactivity, which has been linked to a multitude of illnesses throughout the lifespan. To further understand the link between physical inactivity and illness, it is important to determine the effect that physical activity has various components of wellbeing. The primary aim of this review was to compile and synthesise the recent evidence on physical activity and its effect on physical, mental and social wellbeing across younger populations. The secondary aim was to determine whether there is relationship between the amount, type and intensity of exercise, and changes in wellbeing outcomes.MethodsMain databases were searched using MeSH terms for the population of interest (young adult, adolescent), intervention (physical activity) and outcome (wellbeing). Upon screening papers of eligibility, quality appraisal was completed through the Critical Appraisals Skills Programme (CASP).ResultsNineteen studies were included in this review. The majority of studies found an associated link between the participation of physical activity and improvements in physical, mental and social wellbeing outcomes. There was evidence to suggest that lower levels of physical intensity produced similar results in mental and social outcomes when compared to higher levels of physical intensity.ConclusionThis review supports the encouragement of adolescent and young adult physical activity, noting the improvements seen across the physical, mental and social wellbeing outcomes. Future research is still required to further understand the benefits of lower intensity exercise within the adolescent and young adult population.
Development and application of quality measures of clinical pharmacist services provided in inpatient/acute care settings
Authors: Acquisto Nicole M. , Beavers Craig J. , Bolesta Scott , Buckley Mitchell S. , Dobbins Kelsey F. , Finch Christopher K. , Hayes Sarah M. , Holdren Danielle B. , Johnson Steven T. , Kane‐Gill Sandra L. , Lat Ishaq 
Published: November 2021

AbstractAs health care transitions to value‐based care, it is more critical than ever to emphasize and quantify the impact on patient outcomes made by inpatient/acute care pharmacists and pharmacist extenders as members of the interprofessional care team. Thus, the American College of Clinical Pharmacy (ACCP) took to task the development of quality measures that were broadly applicable to the diverse inpatient/acute care landscape and important for standardizing practice, measuring impact, contextualizing benefit within the health care landscape, and allowing benchmarking within and between institutions. A framework was established by the writing committee of this paper in order to develop quality measures in a methodical manner. The resulting process led the writing committee to devise 31 foundational quality measures to be used in efforts to champion the pharmacist's role in achieving the quadruple aims in health care. Application and evaluation of quality measure performance as well as limitations and future implications of the measures are addressed to further highlight the evolving role of the inpatient/acute care pharmacist and pharmacist extender.
Psychopathic dispositions and emotion dysregulation: A dual‐disposition model perspective
Authors: Guo Peiyang , Wang Mengya , Cheng Cheng , Chen Hao 
Published: November 2021

AbstractThe Dual‐Disposition Model proposes to understand psychopathy through two dispositions (i.e., threat sensitivity and poor inhibitory control) with distinct etiological substrates. In the current study, we examined the predictive contributions of threat sensitivity, poor inhibitory control, and their interaction to emotion dysregulation in 694 Chinese undergraduates based on the Disinhibition subscale of Triarchic Psychopathy Measure, Behavioral Inhibition System Scale, and Difficulties in Emotion Regulation Scale. Our results suggested that two dispositions have independent contributions to emotion dysregulation. Additionally, interactive effects of two dispositions were found for emotion awareness, impulse control, emotional acceptance, and limited emotion regulation strategies when upset. These provide evidence that deficits associated with poor inhibitory control can be selectively suppressed by low threat sensitivity or exacerbated by high threat sensitivity. Training individuals with high psychopathic dispositions to focus on their emotional state might be able to enhance their ability of emotion regulation.
(Not) minding the gap: A qualitative interview study of how social class bias can influence youth mentoring relationships
Authors: Spencer Renée , McCormack Martha J. , Drew Alison L. , Gowdy Grace , Keller Thomas E. 
Published: November 2021

AbstractThis study sought to examine how social class bias may be enacted by mentors and mentoring program staff within community‐based youth mentoring relationships and how these biases may influence the mentoring relationship. A narrative thematic analysis was conducted with interviews from mentors, mentees’ parents/caregivers, and mentoring program staff representing 36 matches participating in a larger, prospective, mixed‐methods study examining factors associated with early match closures. Findings indicate that although some mentors were able to partner with the youth and family to effectively navigate challenges related to the family's economic circumstances, other mentors and some mentoring program staff held deficit views of the youth and their family that appeared to be at least partially rooted in negative social class‐based assumptions about attitudes and behaviors. Specifically, we observed tendencies on the part of some mentors and program staff toward (a) deficit‐based views of families and youth, (b) individual‐level attributions for the family's economic circumstances and blaming of caregivers, and (c) perceiving mentors as being underappreciated by the youth's caregiver. These deficit perspectives contributed to the minimization of parent/caregiver voice in the mentoring process and negative interpretations of parent/caregiver and, in some cases, youth attitudes and behaviors.
Preparing for the 2070s: Reflections from the Journal of Community Psychology's initial decade: Pathways to Community Psychology's continuing maturation
Authors: Lorion Raymond P. 
Published: November 2021

AbstractThis commentary introduces a virtual monograph that celebrates the 50th anniversary of the Journal of Community Psychology. The commentary focuses on originating goals of the discipline and pathways taken in their pursuit and change. The monograph challenges current leaders to define pathways for the next 50 years.
The link between food insecurity and psychological distress: The role of stress exposure and coping resources
Authors: Ciciurkaite Gabriele , Brown Robyn Lewis 
Published: November 2021

AbstractThis study examines the association between food insecurity and mental health over a 3‐year period. It also assesses the salience of life stressors and psychosocial coping resources for this association. We utilize data from a two‐wave community survey of Miami‐Dade County, Florida residents (N = 1488). Findings from SEM analysis reveal that greater food insecurity at W1 is associated with greater depressive symptoms at W2, lending credence to characterizations of food insecurity as a chronic stressor. This association is partly mediated by variation over the study period in social support and mastery. However, no significant mediating effects are observed for the social stress indicators assessed. Food insecurity is associated with diminished psychosocial coping resources, which leads to greater psychological distress. We discuss how these findings extend a stress and coping model of food insecurity, and implications for research and practice.
The effect of social support on work stress in health workers during the pandemic: The mediation role of resilience
Authors: Karadaş Ayşe , Duran Songül 
Published: November 2021

AbstractStressful experiences commonly increase among health workers during the coronavirus disease 2019 (COVID‐19) pandemic. From this perspective, this study primarily aimed to examine the mediating role of resilience in the effect of perceived social support on work stress among health workers. The sample of the study consisted of 402 health workers. In the research, the “General Work Stress Scale,” “Brief Resiliency Scale,” and “Multidimensional Scale of Perceived Social Support” were used. There was a statistically significant negative correlation between work stress and social support (r = −0.223, p = 0.00) and resilience (r = −0.432, p = 0.00), and a statistically significant positive correlation between social support and resilience (r = 0.226, p = 0.00). Resilience mediates the relationship between perception of social support and work stress. When planning effective intervention strategies, it will be critical to reduce the risk of adverse mental health outcomes in health workers, who are fighting against the COVID‐19 pandemic, by increasing social support and resilience and reducing work stress.
Anterior‐posterior patterning of segments in Anopheles stephensi offers insights into the transition from sequential to simultaneous segmentation in holometabolous insects
Authors: Cheatle Jarvela Alys M. , Trelstad Catherine S. , Pick Leslie 
Published: November 2021

AbstractThe gene regulatory network for segmentation in arthropods offers valuable insights into how networks evolve owing to the breadth of species examined and the extremely detailed knowledge gained in the model organism Drosophila melanogaster. These studies have shown that Drosophila's network represents a derived state that acquired changes to accelerate segment patterning, whereas most insects specify segments gradually as the embryo elongates. Such heterochronic shifts in segmentation have potentially emerged multiple times within holometabolous insects, resulting in many mechanistic variants and difficulties in isolating underlying commonalities that permit such shifts. Recent studies identified regulatory genes that work as timing factors, coordinating gene expression transitions during segmentation. These studies predict that changes in timing factor deployment explain shifts in segment patterning relative to other developmental events. Here, we test this hypothesis by characterizing the temporal and spatial expression of the pair‐rule patterning genes in the malaria vector mosquito, Anopheles stephensi. This insect is a Dipteran (fly), like Drosophila, but represents an ancient divergence within this clade, offering a useful counterpart for evo‐devo studies. In mosquito embryos, we observe anterior to posterior sequential addition of stripes for many pair‐rule genes and a wave of broad timer gene expression across this axis. Segment polarity gene stripes are added sequentially in the wake of the timer gene wave and the full pattern is not complete until the embryo is fully elongated. This “progressive segmentation” mode in Anopheles displays commonalities with both Drosophila's rapid segmentation mechanism and sequential modes used by more distantly related insects.
Southern Baffin Island mean annual precipitation isotopes modulated by summer and autumn moisture source changes during the past 5800 years
Authors: Gorbey Devon B. , Thomas Elizabeth K. , Crump Sarah E. , Hollister Kayla V. , Raynolds Martha K. , Raberg Jonathan H. , de  Wet Gregory , Sepúlveda Julio , Miller Gifford H. 
Published: November 2021

ABSTRACTPaleo water isotope records can elucidate how the Arctic water cycle responded to past climate changes. We analyze the hydrogen isotope composition (δ2H) of plant‐derived n‐alkanoic acids (waxes) from Lake Qaupat, Baffin Island, Nunavut, Canada, to assess moisture sources and seasonality during the past 5.8 ka. We compare this record to a sedimentary ancient DNA (sedaDNA)‐inferred vascular plant record from the same lake, aiming to overcome the uncertainty of plant community impacts on leaf waxes. As the sedaDNA record reveals a stable plant community after the colonization of Betula sp. at 6.1 ka, we interpret plant wax δ2H values to reflect climate, specifically mean annual precipitation δ2H. However, the distributions of n‐alkanoic acid homologs suggest that aquatic mosses, which are not represented in the sedaDNA record, may become more abundant towards the present. Therefore, we cannot exclude the possibility that changes in the plant community cause changes in the plant wax δ2H record, particularly long‐chain waxes, which become less abundant through this record. We find that Lake Qaupat mid‐chain plant wax δ2H is enriched coincident with high Labrador Sea summer surface temperature, which suggests that local moisture sources in summer and early autumn have the greatest impact on precipitation isotopes in this region.
Balancing reality in embedded research and evaluation: Low vs high embeddedness
Authors: Jackson George L. , Damschroder Laura J. , White Brandolyn S. , Henderson Blake , Vega Ryan J. , Kilbourne Amy M. , Cutrona Sarah L. 
Published: November 2021

AbstractEmbedding research and evaluation into organizations is one way to generate “practice‐based” evidence needed to accelerate implementation of evidence‐based innovations within learning health systems. Organizations and researchers/evaluators vary greatly in how they structure and operationalize these collaborations. One key aspect is the degree of embeddedness: from low embeddedness where researchers/evaluators are located outside organizations (eg, outside evaluation consultants) to high embeddedness where researchers/evaluators are employed by organizations and thus more deeply involved in program evolution and operations. Pros and cons related to the degree of embeddedness (low vs high) must be balanced when developing these relationships. We reflect on this process within the context of an embedded, mixed‐methods evaluation of the Veterans Health Administration (VHA) Diffusion of Excellence (DoE) program. Considerations that must be balanced include: (a) low vs high alignment of goals; (b) low vs high involvement in strategic planning; (c) observing what is happening vs being integrally involved with programmatic activities; (d) reporting findings at the project's end vs providing iterative findings and recommendations that contribute to program evolution; and (e) adhering to predetermined aims vs adapting aims in response to evolving partner needs.
Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications
Authors: Yang Chengbin , Lin Zheng‐Ian , Chen Jian‐An , Xu Zhourui , Gu Jiayu , Law Wing‐Cheung , Yang Jason Hsiao Chun , Chen Chih‐Kuang 
Published: November 2021

AbstractSince the conceptualization of nanomedicine, numerous nanostructure‐mediated drug formulations have progressed into clinical trials for treating cancer. However, recent clinical trial results indicate such kind of drug formulations has a limited improvement on the antitumor efficacy. This is due to the biological barriers associated with those formulations, for example, circulation stability, extravasation efficiency in tumor, tumor penetration ability, and developed multi‐drug resistance. When employing for nanomedicine formulations, pristine organic‐based and inorganic‐based nanostructures have their own limitations. Accordingly, organic/inorganic (O/I) hybrids have been developed to integrate the merits of both, and to minimize their intrinsic drawbacks. In this context, the recent development in O/I hybrids resulting from a self‐assembly strategy will be introduced. Through such a strategy, organic and inorganic building blocks can be self‐assembled via either chemical covalent bonds or physical interactions. Based on the self‐assemble procedure, the hybridization of four organic building blocks including liposomes, micelles, dendrimers, and polymeric nanocapsules with five functional inorganic nanoparticles comprising gold nanostructures, magnetic nanoparticles, carbon‐based materials, quantum dots, and silica nanoparticles will be highlighted. The recent progress of these O/I hybrids in advanced modalities for combating cancer, such as, therapeutic agent delivery, photothermal therapy, photodynamic therapy, and immunotherapy will be systematically reviewed.
Significant Performance Improvement of Thermoplastic Polyurethane Composites by Multiple Effects of Monodispersed Graphene: Micro‐Crosslinking, Isolation, and Induced Crystallization
Authors: Yang Lide , Lou Jiankun , Yuan Jianmin , Deng Jianru 
Published: November 2021

AbstractThermoplastic polyurethane composites (TPCs) in kilogram scale reinforced with monodispersed functionalized graphene (FGr) are prepared by melt‐blending on industrial extruder and their properties are studied in this work. It shows that the saturation content of monodispersed FGr in TPCs is ≈0.5 wt%, beyond which part of it will agglomerate. The multiple effects of monodispersed FGr—micro‐crosslinking, isolation, and induced crystallization—have great impact on the properties of TPCs. With the content increase of FGr, the melt rheological properties, crystallization properties, mechanical properties, and shape memory properties of TPCs show regular changes. More importantly, the tensile fracture behaviors of TPCs are dramatically changed by FGr. Some microfibers with high strength are formed and lay astride the cracks to prevent crack propagation during the damage process. Therefore, the tensile strength of TPC with 0.5 wt% FGr is maximumly improved, showing an increase of 139% compared to neat thermoplastic polyurethane. Its shape fixed ratio and shape recovery ratio are respectively raised to 96% and 94%, showing a good shape memory performance.