bluuebunny/crossref_metadata_2025_split huggingface dataset:
44/47 Scandium Labelled Cholecystokinin Derivative for Cancer Theragnostics
Authors: Cho Eun-ha , Lim Jae‑cheong , Lee So‑young , Park Ul-jae 
Published: October 2021

Abstract
The cholecystokinin (CCK) receptors are known to overexpress in various types of tumors. Through a previous study, a cyclic CCK analogue, DOTA-[Nle]-cCCK, was confirmed to have high in vivo stability and the tumor target ability of DOTA-[Nle]-cCCK capable of binding to the CCK receptor was confirmed through Lu-177 labeling. In this study, DOTA-[Nle]-cCCK was labeled with the pair-isotope, Sc-44/47, to confirm a technology that possibly could be applicable to radiopharmaceutical. First, we confirmed that the CCK receptor was overexpressed in AR42J, a cancer cell overexpressed in cancer tissue, and measured the binding ability of the receptor and DOTA-[Nle]-cCCK. We established the labeling method of radioactive scandium, and we confirmed that the Sc-44 labeled DOTA-[Nle]-cCCK administered to mice remained mostly in the bladder within an hour. Cell experiments with Sc-47 labeled DOTA-[Nle]-cCCK confirmed that more than half of the cancer cells were killed at a concentration of 5 MBq/ml. Through this study, we were able to confirm the diagnostic/therapeutic applicability of the DOTA-[Nle]-cCCK label with pair-isotope Sc-44/47.
Litter Mixing Effect On Decomposition Rate And Nutrient Release: Low-Quality Leaves of Coastal Species
Authors: Ndayambaje Patrick , Wei Lili , Zhang Tingfeng , Liu Lin , Huang Xu , Li Jie , Tian Shaohua , Xin Yu , Sun Xuecong , Liu Chaoxiang 
Published: October 2021

Abstract
Coastal wetlands are among the most carbon-rich ecosystems in the world. Litter decomposition is a major process controlling soil carbon input. Litter mixing has shown a non-additive effect on the litter decomposition of terrestrial plants particularly of those species having contrasting litter quality. But the non-additive effect has been rarely tested in coastal plants. We selected three common mangrove species and one saltmarsh species, co-occurring in subtropical coasts, to test whether the non-additive effect occurs when the litters of these coastal species mixing together. We are also concerned whether the changes in the decomposition rate of litter will affect the nutrient contents in waters. A litter-bag experiment was carried out in a glasshouse with single and mixed leaf litters. A non-additive effect was observed in the litter mixtures of mangrove species Aegiceras corniculatum vs. Kandelia obovata (antagonistic) and A. corniculatum vs. Avicennia marina (synergistic). Whereas, the mixture of A. corniculatum (mangrove species) and Spartina alterniflora (saltmarsh species) showed an additive effect. The strength of the non-additive effect was unrelated to the initial trait dissimilarity of litters. Instead, the decomposition rate and mass remaining of litter mixtures were strongly related to the carbon concentrations in litters. Nutrient content in waters was dependent on the decomposition rate of litter mixtures but not on the initial nutrient concentrations in litters. Despite the behind mechanisms were not yet revealed by the current study, these findings have improved our understanding of the litter decomposition of coastal species and the consequent nutrient release.
Investigating the Effectiveness of an Augmented Reality Game to Enhance the Mathematics Learning Experience of Dyscalculic
Authors: Debnath Tanmay 
Published: October 2021

Abstract
Dyscalculic face a condition where they are unable to comprehend mathematical information. One of the main causes attributed to the same is the poor experience level at various levels of education. The main aim of this study is to design and implement augmented reality (AR) games, by integrating a visual method of performing mathematical operations, for enhancing the experience of Dyscalculic. S total of 31 participants was involved in this study. An online survey was conducted to measure the effectiveness of the developed AR game. The results of the paired-sample T-test indicated that participants in the experimental group have enhanced their mathematical performance level with a substantial decrease in the mean problem-solving time. The findings demonstrate that the proposed game can effectively enhance the performance of the dyscalculic using visual cue representation.
A Rehabilitation Program for Individuals With Chronic Low Back Pain: Protocol for a Randomized Clinical Trial
Authors: Junkes-Cunha Maíra , Sieczkowska Sofia Mendes , Vilarino Guilherme Torres , Bevilacqua Guilherme , Andrade Alexandro 
Published: October 2021

Background
Low back pain (LBP) is the leading cause of disability worldwide. Physical exercise, as a treatment, is beneficial for the improvement of quality of life in patients with LBP, and it is widely accepted.

Objective
We aimed to develop a protocol for a feasibility study that is designed to compare the effectiveness of different interventions in reducing pain, functional, and psychosocial factors among patients with chronic LBP after 8 weeks of randomization.

Methods
This is a study protocol for a randomized controlled trial that will consist of individuals with chronic LBP who are aged between 18 and 65 years. Participants will be allocated, through block randomization, to one of the following groups: the motor control exercises (MCEs), pain education, MCEs+pain education, and usual care groups. The primary outcome will be pain intensity, and the secondary outcomes will be the pressure pain threshold, which will be measured with a digital algometer; LBP-related disability; fears and beliefs; the fear of movement; quality of life; mood states; and levels of depression and anxiety. The trial was approved by the ethics committee for research involving human beings of the Federal University of Pelotas (reference number: 5.717.390) in September 2022, and it will be conducted until August 2023.

Results
The researchers are being trained to apply the questionnaires and carry out the interventions. Patient recruitment will begin at the end of 2022 and results are expected to be achieved by August 2023.

Conclusions
Our trial will provide preliminary data regarding the feasibility and safety of MCEs and pain education for patients with LBP. It will also provide preliminary outcome data that can be used to identify the most efficient intervention and the level of health care that should be implemented in public health services.

Trial Registration
Brazilian Registry of Clinical Trials U1111-1221-4106; https://ensaiosclinicos.gov.br/rg/RBR-2xx2r2/

International Registered Report Identifier (IRRID)
PRR1-10.2196/31345
The Looming Central and Eastern European Real Convergence Club. Do Implicit Tax Rates Play a Part?
Authors: Donath Liliana E. , Mura Petru-Ovidiu 
Published: October 2021

Abstract
The paper investigates whether there is a convergence club stance for the Visegrad countries plus Romania and Bulgaria and the part played, in this process, by the implicit tax rates on labour and consumption, respectively. For the purpose of the research, the GDP per capita, productivity and unemployment are used as convergence indicators and dependent variables. The dataset covers the 1995–2016 timeframe and the analysis is based on a panel-model approach. The main results show that the implicit tax on labour has no significant effect on the convergence indicators while the implicit rates on consumption are statistically significant with negative influence. The interpretation of results is made considering a set of control and robustness variables where policy lessons derive from. The conclusion reflects on the policy lessons that can serve to accomplish the convergence club within selected CEE countries: Bulgaria, the Czech Republic, Hungary, Poland, Slovakia and Romania.
Conceptual Framework and Empirical Methodology for Measuring Multidimensional Judicial Ideology
Authors: Avbelj Matej , Šušteršič Janez 
Published: October 2021

AbstractThe article presents a conceptual framework and empirical methodology of an on-going research on the role of ideology in the decisions of the Slovenian Constitution Court. The literature review demonstrates that research on judicial ideology in the courts of European countries and international courts is still rare. This can be explained by conceptual, methodological and empirical challenges posed by this type of research. The article hence advances a conceptual framework which is, contra to the mainstream theoretical approach in the field, based on a multidimensional conception of ideology that is empirically operationalised along the economic, social and authoritarian dimensions with five possible ideological positions on each dimension. By applying the newly developed methodology to a sample of Court’s decisions, it is demonstrated that this methodological approach is able to account for ideological differences between judges. This confirms that (judges’) ideology is a complex multidimensional set of values and convictions that cannot be reduced to simply equating ideology with (possible) political affiliations.
Transparency in Public Procurement – the Case of Slovenia
Authors: Kirn Matej , Umek Lan , Rakar Iztok 
Published: October 2021

Abstract
Public procurement is one of the key points of contact between public administration and the economy, while the amount of public resources is a possible source of conflict of interest and corruption. The article aims to contribute to improvements in public procurement legislation and practice. The article examines the practice of supervisory bodies and assesses the frequency of violations of the principle of transparency. The main findings of the article are that over the years of application of the Public Procurement Act in versions ZJN-2 and ZJN-3, the number of violations of the basic principle of transparency increased – the most frequent violations concerning discriminatory criteria set by the contracting authorities and their implementation in the selection phase – and that local municipal bodies violated the principle of transparency more often than state bodies.
Introduction: A Contemporary Guide to Tax Justice and Tax Fairness
Authors: Lind Yvette 
Published: October 2021

Abstract
This is an introduction to the research papers that make out this Nordic Tax Journal special issue on inequality within the international tax regime. The special issue is an outcome of the discussions that took place at the (online) conference hosted by Copenhagen Business School in September 2020. In addition to introducing the papers of this special issue, this introduction also provides a contemporary guide to tax justice and tax fairness with an emphasis on theories and principles applicable to the international tax context as this was the overall theme of the conference.
Hybrid event strategy for the fishing community (Case study of the fisherman community of Beba hamlet, Takalar regency during the Covid-19 pandemic)
Authors: Sabiq Muhammad , Asriandi Asriandi 
Published: October 2021

This study examines the concept of Hybrid Event as a new strategy that is considered reliable enough for fishing communities in Makassar to face new normal conditions. New economic spaces have been created for fishermen and UMKM fishermen who have been affected by Covid-19. The old economic spaces are no longer reliable because they are constrained by laws and regulations from the government that require restrictions on social distancing and physical distancing. The purpose of this study was to analyze the readiness of the fishing community and fishermen UMKM actors in Beba, Tamasaju Village, North Galesong District, Takalar Regency to enter business era 4.0 in the midst of the Covid-19 pandemic and assist the realization of government policies in providing socio-economic protection to fishing communities and as well as UMKM fishermen in Makassar. The resulting output is in the form of four (4) main strategies: first, combining physical and virtual meetings, so that fishermen's businesses and businesses and fishermen's UMKM continue to run in various different atmospheres. Second, health protocols such as maintaining physical distance and social distance are not violated and at the same time the pace of economic activity of fishing communities and fishing UMKM can still run normally. Third, empowering fishing communities and fishing UMKM in using appropriate information technology. And fourth, the government's budget policy for fishing communities and fishing UMKM that are oriented to the provision of appropriate information technology
Activité antioxydante de 53 plantes réputées antimalariques en République Démocratique du Congo
Authors: Bashige V.C. , Bakari A.S. , Kahumba B.J. , Lumbu J.-B.S. 
Published: October 2021

Objectif: Cette étude vise à identifier des groupes phytochimiques et à évaluer l’activité antioxydante de 53 plantes utilisées en médecine traditionnelle à Bagira dans le traitement de la malaria.Méthode: Le criblage phytochimique s’est effectué par des réactions classiques en solution, et l’activité antioxydante a utilisé la méthode in vitro au DPPH.Résultats: Le criblage chimique a permis d’identifier des métabolites secondaires à potentiel à la fois antimalarique et antioxydant comme des coumarines, des saponines, des stéroïdes, des tanins et des terpénoïdes dans plus de 70 % des plantes. Le criblage antioxydant a révélé pour la première fois l’activité antioxydante de 17 plantes parmi lesquellesDalbergia katangensis, Dialium angolense et Solanecio cydoniifoliusavec des CI50inférieures ou égales à 1,6 μg/ml présentent les activités antioxydantes les plus élevées de la série.Conclusion: Cette étude montre que parmi les plantes réputées antimalariques à Bagira (RDC) plusieurs possèdent un pouvoir antioxydant et contiennent des groupes présumés à la fois antioxydants et antimalariques. Elle suggère que les études ultérieures se poursuivent en vue d’isoler les composés responsables de l’activité prouvée.
ANALISIS DESAIN PEMBELAJARAN PKN DI SD/MI KELAS TINGGI
Authors: Wandini Rora Rizky , Maghfhirah Siti , Hasibuan Ahmad Tarmizi 
Published: October 2021

Abstract
Citizenship education teaches students to know everything that includes themselves and their country. At the end, students will be asked to apply the values of this subject. For example, on theme national identity which means identity of Indonesian nation, namely Pancasila. By implementing Pancasila in everyday life, it means that the students have shown their national identity. However, in this case, the effort to apply PKn in daily life is not an easy thing, therefore it is necessary for students to prepare PKn learning designs so the students enjoy the lesson and make it easier for them to apply the content of PKn subject values. This study uses the literature study method. The author collects various data sources as reference material to complete this paper. The results of the study, it can be concluded that PKn Learning Design in Higher Class of SD/MI, 1) the use visual media, 2) the method of question and answer, 3) the use of Picture Media, 4) the use of Multimedia, 5) an active, creative, effective, and effective learning approach. fun, 6) Horay course review model by using power point, 7) the use of Learning Media, 8) the use of Discussion Method, 9) Active learning strategy of crossword puzzle type.
Keywords: Learning Design, PKn, Higher Class
Pengaruh Celebrity Endorser dan Label Halal terhadap Keputusan Pembelian Produk Kosmetik Wardah Di Kota Lhokseumawe
Authors: Fuadi  , Munandar  , Khairawati  , Muhammad Miftahul Jannah 
Published: October 2021

Abstract
This study aims to determine how much influence celebrity endorsers and halal labels have on purchasing decisions for Wardah cosmetic products in Lhokseumawe City. This study uses primary data obtained by distributing questionnaires to 100 respondents selected using the Accidental sampling technique. The data analysis method used is multiple linear regression analysis. The results simultaneously and partially show that celebrity endorsers and halal labels significantly influence purchase decisions for Wardah cosmetic products in Lhokseumawe City. Result of the research shown that simultaneously give significant effect to buyer decision Wardah cosmetic product in Lhokseumawe City and has result F-statistic > F-table (373,379 > 2,31) and has positive relation. While partially celebrity endorser gave positive and siginificant effect to buyer decision with result T-statistic > T-table (3,090 > 1.66). and halal label also gave positive and significant effect to buyer decision Wardah Cosmetic Product in Lhokseumawe City with T-statistic > T-table (13,194 > 1,66).

Keywords: Celebrity endorser, Halal label, Purchase decision.

Abstrak
Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh celebrity endorser dan label halal terhadap keputusan pembelian produk kosmetik wardah di Kota Lhokseumawe. Penelitian ini menggunakan data primer yang diperoleh melalui penyebaran kuesioner kepada 100 responden yang dipilih menggunakan tekhnik Accidental sampling. Metode analisis data yang digunakan adalah metode analisis regresi linier berganda. Hasil penelitian ini menunjukkan bahwa secara simultan berpengaruh signifikan terhadap keputusan pembelian produk kosmetik wardah Di Kota Lhokseumawe dan memiliki nilai F-statistik > F-tabel (373,379 > 2,31) dan memiliki hubungan positif. Sedangkan secara parsial celebrity endorser berpengaruh positif dan signifikan terhadap keputusan pembelian dengan nilai T-statistik > T-tabel (3,090 > 1,66). Dan label halal juga berpengaruh positif dan signifikan terhadap keputusan pembelian produk kosmetik wardah Di Kota Lhokseumawe dengan nilai T-statistik > T-tabel (13,194 > 1,66).
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UPAYA PENINGKATAN STATUS KESEHATAN BALITA MELALUI PENYULUHAN DAN KONSELING GIZI
Authors: Noor Prastia Tika 
Published: October 2021

Makanan meurupakan kebutuhan dasar manusia yang pemenuhannya memiliki peranan sangat peniting dalam pertumbuhan dan perkembanga balita. Salah satu faktor yang berkaitan dengan masalah gizi pada anak balita adalah kurangnya informasi dan edukasi yang diberikan sehingga menyebabkan rendahnya pengetahuan ibu dalam pemenuhan gizi balita. Permasalahan yang ditemukan di RW 01 Kelurahan Bojongkerta berkaitan dengan pemenuhan gizi balita. Tujuan kegiatan ini adalah untuk memberikan pemahaman dan pengetahuan tentang gizi agar tercapai pemenuhan gizi yang lebih baik dan meningkatkan derajat kesehatan balita melalui metode penyuluhan dan konseling gizi. Penyuluhan dan konseling gizi adalah bagian dari pendidikan gizi yang dapat membantu meningkatkan kesadaran dan mengatasi masalah kesehatan. Kegiatan dilakukan di wilayah RT 01 & 02 RW 01 Kelurahan Bojongkerta dengan jumlah sasaran sebanyak 30 orang meliputi ibu balita, ibu hamil, dan ibu menyusui. Hasil dari kegiatan ini menunjukkan adanya peningkatan pengetahuan dan perubahan perilaku dalam pola pemenuhan gizi balita. Diharapkan bagi petugas lapangan baik kader maupun bidan desa untuk melakukan pemantauaan pola perilaku dan meningkatkan akses pelayanan informasi yang memadai terkait gizi kepada masyarakat.
GAMBARAN PELAKSANAAN PROGRAM PENGELOLAAN PENYAKIT KRONIS (PROLANIS) PASIEN HIPERTENSI DI PUSKESMAS LAWANGGINTUNG KOTA BOGOR TAHUN 2018
Authors: Isnadia Imaroh , Maryati Husnah , Masitha Arsyati Asri 
Published: October 2021

Prolanis merupakan salah satu strategi promotif dan preventif yang dilakukan oleh BPJS Kesehatan untuk menurunkan atau mencegah komplikasi penyakit kronis yang diderita oleh peserta sekaligus sebagai kendali biaya pelayanan kesehatan. Penelitian ini bertujuan untuk mengetahui gambaran pelaksanaan program Prolanis pada pasien hipertensi di Puskesmas Lawangintung Kota Bogor tahun 2018. Penelitian ini menggunakan metode kualitatif dengan jenis rancangan deskriptif. Informan terdiri dari 6 orang terdiri dari Kepala Puskesmas, Penanggung Jawab Prolanis, Petugas Pelaksana Prolanis, dan Peserta Prolanis. Instrumen penelitian yang digunakan yaitu pedoman wawancara mendalam. Hasil penelitian menunjukkan bahwa dari faktor input yaitu ketersediaan SDM sudah cukup, serta tersedianya sarana dan prasarana untuk kegiatan. Puskesmas Lawanggintung tidak melakukan klaim dana kegiatan Prolanis dan tidak memiliki SOP khusus terkait pelaksanaan Prolanis. Hasil dari proses pelaksanaan kegiatan Prolanis di Puskesmas Lawanggintung secara umum sudah bagus dan masih berjalan sampai saat ini. Hasil dari faktor output bahwa klub PPHT Prolanis Puskesmas Lawanggintung terkontrol dan berhasil mencapai indikator 75% peserta memperoleh hasil baik pada pemeriksaan bulan Oktober 2018. Peneliti menyarankan agar BPJS Kesehatan Pusat untuk membuat standar Operasional Prosedur (SOP) program Prolanis bagi FKTP, karena dengan adanya SOP diharapkan PIC dan petugas pelaksana Prolanis dapat bekerja secara lebih terarah dan rinci sesuai standar yang berlaku.
GAMBARAN PELAKSANAAN PROGRAM PENYAKIT HIPERTENSI DI PUSKESMAS KEMANG KABUPATEN BOGOR TAHUN 2019-2020
Authors: Efrina Rina , Syari Wirda , Masitha Arsyati Asri 
Published: October 2021

Hipertensi adalah salah satu penyebab utama kematian dini di seluruh dunia. Di tahun 2020 sekitar 1,56 milyar orang dewasa akan hidup dengan hipertensi. Hipertensi merupakan salah satu penyakit tertinggi di Puskesmas Kemang. Tahun 2019, target penemuan kasus hipertensi dari Kemenkes untuk Puskesmas Kemang adalah 27,3% tetapi hanya tercapai 4,18%. Penelitian ini bertujuan untuk mengetahui gambaran pelaksanaan program penyakit hipertensi di Puskesmas Kemang Kabupaten Bogor. Jenis penelitian ini adalah penelitian deskriptif kualitatif. Informan dalam penelitian ini adalah petugas puskesmas, kader, dan pasien yang terdiagnosa penyakit hipertensi. Instrumen yang digunakan adalah wawancara mendalam, observasi dan telaah dokumen. Hasil penelitian menunjukan bahwa untuk variabel input, SDM serta sarana dan prasarana di Puskesmas sudah mencukupi tetapi di posbindu masih kurang. Anggaran untuk program PTM dari anggaran BOK dan JKN. SOP sudah cukup terlaksana dengan baik. Untuk variabel proses, deteksi dini dilaksanakan menggunakan sistem 5 meja di posbindu, masalah dari deteksi dini adalah masih banyak masyarakat yang tidak mengunjungi Posbindu, serta masih banyak masyarakat yang belum menyadari pentingnya kesehatan. Program pandu PTM rujukan dari posbindu ke puskesmas untuk di tindak lanjut, masalah di Program Pandu PTM adalah masyarakat yang sudah dirujuk untuk ke puskesmas tidak semua datang karena jarak yang jauh untuk ke puskesmas. Untuk variabel proses, angka pencapaian penemuan kasus penyakit hipertensi tahun 2019 baru mencapai 4,18 dari target Kemenkes 27,3%,. Kesimpulan penelitian ini adalah program penyakit hipertensi belum mencapai target Kemenkes, karena ada beberapa variabel input, proses dan output yang belum terlaksana dengan optimal.