bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficiency of continuous renal replacement therapy for rewarming of patients in accidental hypothermia––An experimental study
Authors: Mendrala Konrad , Kosiński Sylweriusz , Podsiadło Paweł , Pasquier Mathieu , Mazur Piotr , Paal Peter , Gajniak Dariusz , Darocha Tomasz 
Published: July 2021

AbstractSevere accidental hypothermia carries high mortality and morbidity and is often treated with invasive extracorporeal methods. Continuous veno‐venous hemodiafiltration (CVVHDF) is widely available in intensive care units. We sought to provide theoretical basis for CVVHDF use in rewarming of hypothermic patients. CVVHDF system was used in the laboratory setting. Heat balance and transferred heat units were evaluated for the system without using blood. We used 5L of crystalloid solution at the temperature of approximately 25°C, placed in a thermally insulated tank (representing the “central compartment” of a hypothermic patient). Time of warming the central compartment from 24.9 to 30.0°C was assessed with different flow combinations: “blood” (central compartment fluid) 50 or 100 or 150 mL/min, dialysate solution 100 or 1500 mL/h, and substitution fluid 0 or 500 mL/h. The total circulation time was 1535 minutes. There were no differences between heat gain values on the filter depending on blood flow (P = .53) or dialysate flow (P = .2). The mean heating time for “blood” flow rates 50, 100, and 150 mL/min was 113.7 minutes (95% CI, 104.9‐122.6 minutes), 83.3 minutes (95% CI, 76.2‐90.3 minutes), and 74.7 minutes (95% CI, 62.6‐86.9 minutes), respectively (P < .01). The respective median rewarming rate for different “blood” flows was 3.6°C/h (IQR, 3.0‐4.2°C/h), 4.8 (IQR, 4.2‐5.4°C/h), and 5.4 (IQR, 4.8‐6.0°C/h), respectively (P < .01). The dialysate flow did not affect the warming rate. Based on our experimental model, CVVHDF may be used for extracorporeal rewarming, with the rewarming rates increasing achieved with higher blood flow rates.
Mineral requirements for weight gain in growing male Santa Inês and Morada Nova hair sheep
Authors: Costa Roberto , Silva Juscelino , Medeiros Ariovaldo , Carvalho Francisco , Andrade Maria , Cruz George , Dias‐Silva Tairon Pannunzio , Bezerra Leilson 
Published: July 2021

AbstractThis study estimated the net macro and micromineral requirement from the 48 male uncastrated lambs (24 growing male Santa Inês and 24 growing male Morada Nova hair sheep), with initial weights of 21.7 ± 1.2 kg and 20.8 ± 0.8 kg using the comparative slaughter method. The experimental diet consisted of 30% forage (Buffel—Cenchrus ciliaris (L) hay) and 70% concentrate (corn grain 43.5%, soybean meal 22.0%, vegetable oil 3.0% and mineral supplement 1.5%). The experimental design was a completely randomized with two breeds, four weights, and six replicate. Mineral requirements sufficient to promote weight gain in Santa Inês sheep ranged from 1.75 to 1.03 g Ca, 1.01 to 0.61 g of P, 0.38 to 0.21 g of K, 0.38 to 0.16 of Na, 0.10 to 0.06 Mg, 28.5 to 16.0 mg of Fe, 6.14 to 3.22 mg of Cu, and Zn 23.0 to 14.0 mg/kg per unit of empty body weight (EBW) gain. In the Morada Nova breed, the requirements ranged from 1.96 to 0.84 g of Ca, 1.15 to 0.46 of P, 0.39 to 0.19 of K, 0.28 to 0.13 of Na, 0.10 to 0.05 Mg, 26.2 to 12.9 mg of Fe, 5.59 to 2.46 Cu, and Zn 23.6 to 10.3 mg/kg of EBW gain. Mineral requirements varied mainly in accordance with the proportion of bone mass and fat concentration in the carcass, which were influenced by the slaughter weight of the animals, and therefore should be used in the formulation of dietary mineral supplements.
Osilodrostat in Cushing's disease: The risk of delayed adrenal insufficiency should be carefully monitored
Authors: Castinetti Frederic , Amodru Vincent , Brue Thierry 
Published: July 2021

AbstractAntisecretory data shows a highly effective and prolonged blockade of cortisol secretion with osilodrostat. The drawback is the occurrence of adrenal insufficiency (AI) in roughly a quarter of treated patients. In this short manuscript, we report three cases of atypical adrenal insufficiency with osilodrostat.
Use of environmental DNA in assessment of fish functional and phylogenetic diversity
Authors: Marques Virginie , Castagné Paul , Polanco Andréa , Borrero‐Pérez Giomar Helena , Hocdé Régis , Guérin Pierre‐Édouard , Juhel Jean‐Baptiste , Velez Laure , Loiseau Nicolas , Letessier Tom Bech , Bessudo Sandra , Valentini Alice , Dejean Tony , Mouillot David , Pellissier Loïc , Villéger Sébastien 
Published: July 2021

AbstractAssessing the impact of global changes and protection effectiveness is a key step in monitoring marine fishes. Most traditional census methods are demanding or destructive. Nondisturbing and nonlethal approaches based on video and environmental DNA are alternatives to underwater visual census or fishing. However, their ability to detect multiple biodiversity factors beyond traditional taxonomic diversity is still unknown. For bony fishes and elasmobranchs, we compared the performance of eDNA metabarcoding and long‐term remote video to assess species’ phylogenetic and functional diversity. We used 10 eDNA samples from 30 L of water each and 25 hr of underwater videos over 4 days on Malpelo Island (pacific coast of Colombia), a remote marine protected area. Metabarcoding of eDNA detected 66% more molecular operational taxonomic units (MOTUs) than species on video. We found 66 and 43 functional entities with a single eDNA marker and videos, respectively, and higher functional richness for eDNA than videos. Despite gaps in genetic reference databases, eDNA also detected a higher fish phylogenetic diversity than videos; accumulation curves showed how 1 eDNA transect detected as much phylogenetic diversity as 25 hr of video. Environmental DNA metabarcoding can be used to affordably, efficiently, and accurately census biodiversity factors in marine systems. Although taxonomic assignments are still limited by species coverage in genetic reference databases, use of MOTUs highlights the potential of eDNA metabarcoding once reference databases have expanded.
The effect of bronchiectasis on the exacerbation and mortality of chronic obstructive pulmonary disease
Authors: Fendoğlu Türkan Zeynep , Köktürk Nurdan , Yapar Dilek , Kılıç Pınar , Kılıç Koray , Erbaş Gonca 
Published: July 2021

AbstractBackgroundCoexistence of bronchiectasis with chronic obstructive pulmonary disease (COPD) may lead to the worsening of the functional parameters in exacerbations and may negatively affect the outcomes.MethodsThis study is a retrospective cross‐sectional study that aims to investigate the relationships between bronchiectasis with COPD exacerbation and all‐cause of mortality. We retrospectively enrolled 122 cases hospitalized for COPD exacerbation from 2010 to 2016. Patients who underwent thoracic tomography in the previous year of the index exacerbation were included in the study. Patients who admitted to the intensive care unit and patients with infected bronchiectasis and with conditions that mimic COPD exacerbation were excluded from the study. Demographic, clinical, and laboratory findings, comorbidities and the number of exacerbations in the previous year and the presence of bronchiectasis were recorded using hospital electronic registry. The radiological evaluation of bronchiectasis was made by the modified Reiff score (MRS).ResultsBronchiectasis was found in 66 (54%) of 122 patients included in the study. The mean age was 67.5 ± 10.3 in the whole group, 108 (88.5%) of the patients were male, and 14 (11.5%) were female. When patients were stratified according to the presence of bronchiectasis, no statistically significant difference was found in terms of comorbidity scores, respiratory functions, exacerbation parameters, laboratory values and all cause of mortality between the groups (p > 0.05). There was no statistical relation between the presence of bronchiectasis and long‐term survival (log‐rank test p = 0.83).ConclusionsThis study shows that patients with bronchiectasis did not cause a poor outcome in patients with COPD exacerbation.
Knowledge and perception about asthma among students in a Nigerian single‐sex secondary school
Authors: Amorha Kosisochi Chinwendu , Asogwa Ezinne Queendalyn , Ibenekwu Chisom Sandra , Ogbonna Emmanuella Tochukwu , Amorha Adanne Onyedikachi 
Published: July 2021

AbstractIntroductionAsthma is prevalent among children and adolescents. Few studies have assessed the knowledge and perceptions of asthma among adolescents.ObjectivesThis study assessed the knowledge and perception about asthma among secondary school students in an all‐girls school in Nigeria.MethodsThis cross‐sectional study was conducted in a Nigerian secondary school in Enugu State (February 2020). In Senior Secondary School (SS1, SS2 and SS3), students could be in one of three specialized classes: Sciences, Humanities and Business. A self‐administered structured questionnaire was filled by conveniently sampled students in SS1 and SS2. Inferential statistics utilized the Pearson's chi‐square test and multiple linear regression with statistical significance set as P < 0.05.ResultsThree hundred and eighty‐eight (388) students participated in the study (mean age = 14.64 ± 0.93 years). Majority of the students were in Science class (n = 299; 77.1%). There was high awareness about asthma (n = 384; 99.0%). More than half of them had good asthma knowledge (n = 279; 71.9%); close to three‐fifths had favourable perception of asthma (n = 222; 57.2%). More students in SS2 had good knowledge of asthma compared to those in SS1 (76.7% vs. 67.2%; ꭓ2 = 4.338; P = 0.037). More students in Science class had favourable perceptions about asthma compared with those in Humanities and Business class (60.5% vs. 48.1% vs. 25.0%; ꭓ2 = 7.458; P = 0.024).ConclusionMajority of the students were aware about asthma and had good knowledge of the disease while close to three‐fifths had favourable perceptions about asthma.
Openness processes and new subjectivities: Analysis of the Cuban case
Authors: Palacios Cívico Juan Carlos 
Published: July 2021

AbstractMotivationPrevious studies of the external restrictions on Cuba have not linked it with political subjectivity. Its consideration allows us to make visible discourses and collective imaginations that help us understand the political and economic dynamics of this Caribbean country.PurposeThe article aims to identify the measures, financial flows, and subjectivities that should be projected in the future both to make this external restriction more flexible and long‐term economic growth sustainable.Methods and approachTo this end, it examines, from both a qualitative and quantitative approach, the interaction among the external constraint, openness processes, and subjectivities in the case of Cuba.FindingsHistorically, Cuba has aimed to mitigate the external constraint that has hampered its economic growth through balances of power and strategic alliances compatible with and reinforced by political subjectivity. However, when these alliances have been broken or have been insufficient to compensate for the scarcity of foreign exchange, opening processes that require new subjectivities have had to be adopted.Policy implicationsThe tension between established and emergent subjectivities will define the limits that any opening process in Cuba will face in the future.
The role of RIPK3 in liver mitochondria bioenergetics and function
Authors: Islam Tawhidul , Afonso Marta B. , Rodrigues Cecília M. P. 
Published: July 2021

AbstractBackgroundReceptor‐interacting protein kinase 3 (RIPK3) is a key player of regulated necrosis or necroptosis, an inflammatory form of cell death possibly governing outcomes in chronic liver diseases, such as nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.MethodsThis narrative review is based on literature search using PubMed.ResultsRIPK3 activation depends on post‐transcriptional modifications, including phosphorylation, hence coordinating the assembly of macromolecular death complex named ‘necrosome’, which may also involve diverse mitochondrial components. Curiously, recent studies suggested a potential link between RIPK3 and mitochondrial bioenergetics. RIPK3 can modulate mitochondrial function and quality through the regulation of mitochondrial reactive oxygen species production, sequestration of metabolic enzymes and resident mitochondrial proteins, activity of mitochondrial respiratory chain complexes, mitochondrial biogenesis and fatty acid oxidation.ConclusionsSince mitochondrial dysfunction and RIPK3‐mediated necroptosis are intimately involved in chronic liver disease pathogenesis, understanding the role of RIPK3 in mitochondrial bioenergetics and its potential translational application are of great interest.
Phase‐field‐crystal study on the crack propagation behavior in a nanoscale two‐dimensional lattice in the presence of nonlinear disturbance strains
Authors: Hu Shi , Li Jianwei , Liu Quanyi , He Yuanhua 
Published: July 2021

AbstractThe nanoscale crack propagation behavior in the presence of nonlinear disturbance strains is studied by using the phase‐field‐crystal method. The influences of amplitude A and frequency ω on fracture mode and crack growth are discussed. The simulation results suggest that the disturbance strains can make fracture mode change between brittle fracture and ductile fracture. When amplitude A is large, increasing frequency ω will lead to the brittle‐to‐ductile transition (BDT). Further increasing ω can make ductile‐to‐brittle transition (DBT) happen. Meanwhile, the value of A can influence the critical frequencies for BDT and DBT. Crack growth is also affected by the disturbance strains. When ω is small, increasing ω or A can accelerate crack growth. When ω is large enough, increasing A will retard it. Through this work, we provide a new way to effectively explore the nanoscale mechanism and behavior of crack propagation.
Some reactions: Why my publications after 1982 were not cited or discussed
Authors: Krashen Stephen 
Published: July 2021

ABSTRACTThe lack of citations of previous research is the result of serious problems all readers of scholarly publications have: (1) articles are unnecessarily long (2) they are written in unnecessarily complex prose (3) journal subscriptions and books are very expensive. The solution: Short, clearly written scholarly papers, published in open‐access journals.
Anaphylactoid reaction during hemodiafiltration on AN69 membrane in a patient with atypical hemolytic uremic syndrome: A pediatric case report
Authors: Karakaya Zeynep , Duyu Muhterem , Koksal Atis Seyma 
Published: July 2021

AbstractReactions associated with hemodiafiltration can be life threatening if not recognized early in the course of dialysis. AN69 (acrylonitrile and sodium methallyl sulfonate copolymer) membrane‐associated reactions during hemodialysis have been documented in adult patients receiving angiotensin converting enzyme inhibitors, which are thought to be triggered by the negative charge of the AN69 membrane. Here, we present a 5‐month‐old girl requiring continuous renal replacement therapy (CRRT) for acute kidney injury secondary to atypical hemolytic uremic syndrome who experienced acute cyanosis, angioedema, tachycardia, and impaired circulation during CRRT. After switching to a different type of hemofiltration membrane, her clinical findings improved and she was able to tolerate hemodialysis. We concluded that she had experienced an anaphylactoid reaction to the AN69 membrane. To our knowledge, this case is the first pediatric case report of AN69 membrane‐associated anaphylactoid reaction.
The impact of the 2009 influenza pandemic on the seasonality of human respiratory syncytial virus: A systematic analysis
Authors: Li You , Wang Xin , Msosa Takondwa , de Wit Femke , Murdock Jayne , Nair Harish 
Published: July 2021

BackgroundSeveral local studies showed that the 2009 influenza pandemic delayed the RSV season. However, no global‐level analyses are available on the possible impact of the 2009 influenza pandemic on the RSV season.ObjectivesWe aim to understand the impact of the 2009 influenza pandemic on the RSV season.MethodsWe compiled data from published literature (through a systematic review), online reports/datasets and previously published data on global RSV seasonality and conducted a global‐level systematic analysis on the impact of the 2009 influenza pandemic on RSV seasonality.ResultsWe included 354 seasons of 45 unique sites, from 26 countries. Globally, the influenza pandemic delayed the onset of the first RSV season by 0.58 months on average (95% CI: 0.42, 0.73; maximum delay: 2.5 months) and the onset of the second RSV season by a lesser extent (0.25 months; 95% CI: 0.12, 0.39; maximum delay: 3.4 months); no delayed onset was observed for the third RSV season. The delayed onset was most pronounced in the northern temperate, followed by the southern temperate, and was least pronounced in the tropics.ConclusionsThe 2009 influenza pandemic delayed the RSV onset on average by 0.58 months and up to 2.5 months. This suggests evidence of viral interference as well as the impact of public health measures and has important implications for preparedness for RSV season during the ongoing COVID‐19 pandemic and future pandemics.
Local impedance‐guided radiofrequency ablation with standard and high power: Results of a preclinical investigation
Authors: Osei Kofi , Sulkin Matthew S. , Hamann Jason J. , Hughes Christopher , Shuros Allan , Nagy Tamas , Kapa Suraj , Meyers Jason 
Published: July 2021

AbstractBackgroundLocal impedance (LI) drop measured with microfidelity electrodes embedded in the tip of an ablation catheter accurately reflects tissue heating during radiofrequency (RF) ablation. Previous studies found 15–30 Ω LI drops created successful lesions, while more than 40 Ω drops were associated with steam pops. The objective of this study was to evaluate the safety and efficacy of LI‐guided ablation using standard (30 W) and high‐power (50 W) in a preclinical model.MethodsRF lesions were created in explanted swine hearts (n = 6) to assess the feasibility of LI‐guided ablation by targeting 10, 20, or 30 Ω (n = 20/group) drops. Subsequently, LI‐guided ablation was evaluated in a chronic animal model (n = 8 Canines, 25–29 kg, 30/50 W). During the index procedure point‐by‐point intercaval line ablation and left inferior pulmonary vein (PV) isolation were performed. RF duration was at the operators’ discretion but discontinued early if a 15–30 Ω drop was achieved. Operators attempted to avoid LI drops of more than 40 Ω. At 1‐month, durable conduction block was evaluated with electroanatomic mapping followed by necropsy and histopathology.ResultsIn explanted tissue, terminating ablation at 10, 20, or 30 Ω LI drops created statistically larger lesions (p < .05; 1.8 [1.6–2.4] mm, 3.3 [3.0–3.7] mm; 4.9 [4.3–5.5] mm). LI‐guided high‐power ablation in vivo significantly reduced RF duration per application compared to standard‐power (p < .05; intercaval: 8.9 ± 5.2 vs. 18.1 ± 11.0 s, PV: 9.6 ± 5.4 vs. 23.2 ± 10.3 s). LI drops of 15–40 Ω were more readily achievable for high‐power (90.1%, 318/353) than standard‐power (71.7%, 243/339). All intercaval lines and PV isolations were durable (16/16) at 1‐month. Necropsy revealed no major collateral injury to the pericardium, phrenic nerve, esophagus, or lungs. There was no pericardial effusion, stroke, tamponade, or PV stenosis. Vagal nerve injury was found in two 30 W animals after using 19.7 ± 13.9 and 19.5 ± 11.8 s RF applications.ConclusionLI‐guided ablation was found to be safe and efficacious in a chronic animal model. High‐power ablation more readily achieved more than 15 Ω drops, reduced RF duration compared with standard‐power, and had no major RF collateral injury.
Accuracy of automatic abnormal potential annotation for substrate identification in scar‐related ventricular tachycardia
Authors: Nakatani Yosuke , Maury Philippe , Rollin Anne , Ramirez F. Daniel , Goujeau Cyril , Nakashima Takashi , André Clémentine , Carapezzi Aline , Krisai Philipp , Takagi Takamitsu , Kamakura Tsukasa , Vlachos Konstantinos , Cheniti Ghassen , Tixier Romain , Voglimacci‐Stefanopoli Quentin , Welte Nicolas , Chauvel Remi , Duchateau Josselin , Pambrun Thomas , Derval Nicolas , Hocini Mélèze , Haïssaguerre Michel , Jaïs Pierre , Sacher Frédéric 
Published: July 2021

AbstractIntroductionUltrahigh‐density mapping for ventricular tachycardia (VT) is increasingly used. However, manual annotation of local abnormal ventricular activities (LAVAs) is challenging in this setting. Therefore, we assessed the accuracy of the automatic annotation of LAVAs with the Lumipoint algorithm of the Rhythmia system (Boston Scientific).Methods and ResultsOne hundred consecutive patients undergoing catheter ablation of scar‐related VT were studied. Areas with LAVAs and ablation sites were manually annotated during the procedure and compared with automatically annotated areas using the Lumipoint features for detecting late potentials (LP), fragmented potentials (FP), and double potentials (DP). The accuracy of each automatic annotation feature was assessed by re‐evaluating local potentials within automatically annotated areas. Automatically annotated areas matched with manually annotated areas in 64 cases (64%), identified an area with LAVAs missed during manual annotation in 15 cases (15%), and did not highlight areas identified with manual annotation in 18 cases (18%). Automatic FP annotation accurately detected LAVAs regardless of the cardiac rhythm or scar location; automatic LP annotation accurately detected LAVAs in sinus rhythm, but was affected by the scar location during ventricular pacing; automatic DP annotation was not affected by the mapping rhythm, but its accuracy was suboptimal when the scar was located on the right ventricle or epicardium.ConclusionThe Lumipoint algorithm was as/more accurate than manual annotation in 79% of patients. FP annotation detected LAVAs most accurately regardless of mapping rhythm and scar location. The accuracy of LP and DP annotations varied depending on mapping rhythm or scar location.
Axl‐inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model
Authors: Hoel August , Osman Tarig , Hoel Fredrik , Elsaid Hassan , Chen Tony , Landolt Lea , Babickova Janka , Tronstad Karl Johan , Lorens James B. , Gausdal Gro , Marti Hans‐Peter , Furriol Jessica 
Published: July 2021

AbstractRenal fibrosis is a progressive histological manifestation leading to chronic kidney disease (CKD) and associated with mitochondrial dysfunction. In previous work, we showed that Bemcentinib, an Axl receptor tyrosine kinase inhibitor, reduced fibrosis development. In this study, to investigate its effects on mitochondrial dysfunction in renal fibrosis, we analysed genome‐wide transcriptomics data from a unilateral ureter obstruction (UUO) murine model in the presence or absence of bemcentinib (n = 6 per group) and SHAM‐operated (n = 4) mice. Kidney ligation resulted in dysregulation of mitochondria‐related pathways, with a significant reduction in the expression of oxidative phosphorylation (OXPHOS), fatty acid oxidation (FAO), citric acid cycle (TCA), response to reactive oxygen species and amino acid metabolism‐related genes. Bemcentinib treatment increased the expression of these genes. In contrast, AKT/PI3K signalling pathway genes were up‐regulated upon UUO, but bemcentinib largely inhibited their expression. At the functional level, ligation reduced mitochondrial biomass, which was increased upon bemcentinib treatment. Serum metabolomics analysis also showed a normalizing amino acid profile in UUO, compared with SHAM‐operated mice following bemcentinib treatment. Our data suggest that mitochondria and mitochondria‐related pathways are dramatically affected by UUO surgery and treatment with Axl‐inhibitor bemcentinib partially reverses these effects.