bluuebunny/crossref_metadata_2025_split huggingface dataset:
SNHG6/mir-26a-5p/PIM1 Axis Could Regulate Tumorigenic Glioma Cells Behaviors
Authors: jafari-oliayi Amin , Asadi Malek Hossein 
Published: August 2021

Abstract
Purpose Today, long non-coding RNAs (lncRNAs) are considered more than before. SNHG6 like many lncRNAs is proved to have different roles in human malignancies such as hepatocellular carcinoma, brain cancers and … . Glioma with a poor prognosis needs a faster way to prognosticate. Finding key molecular mechanisms of gliomagenesis is essential for producing effective drugs. We indicated a new possible molecular gliomagenesis pathway involving of PIM1 and mir-26a-5p. Methods SNHG6 expression level was assessed in 29 brain tumor samples. Two specific siRNAs were designed and SNHG6 was silenced in A172 & U87-MG cells. Cell cycle progression, apoptosis, EMT, migration ability and survival of target cells were assessed following of SNHG6 knock-down. Results Expression of SNHG6 in glioma tissues and target cell lines was satisfied. Following of using siRNAs, G1 arrest, mesenchymal characteristics reduction and much apoptosis of U87-MG tumorigenic cells was proved. Target cells demonstrated less proliferation and survival ability when SNHG6 was silenced. Following of SNHG6 knockdown, mir-26a-5p and PIM1 mRNA were fluctuated and U87-MG cells showed this phenomenon more prominent. Conclusion In this research we indicated a new possible molecular pathway that could affect gliomagenesis. SNHG6/mir-26a-5p/PIM1 might be an unknown gliomagenesis molecular pathway for new treatments.
Impact of Age On Short-Term Outcomes After Discharge in Patients With Aneurysmal Subarachnoid Hemorrhage
Authors: Hosogai Masahiro , Ikawa Fusao , Hidaka Toshikazu , Matsuda Shingo , Ozono Iori , Inamasu Joji , Kobata Hitoshi , Horie Nobutaka , Murayama Yuichi , Sato Akira , Kato Yoko , Sano Hirotoshi , Yamaguchi Shuhei 
Published: August 2021

Abstract
Changes in outcome after discharge of patients with aneurysmal subarachnoid hemorrhage (aSAH) have not been examined in detail in recent aging society. This study aimed to clarify the prevalence and factors of changes in outcome in these patients based on a registry database in Japan. Overall, 1,111 radically treated patients with aSAH in the acute stage were selected between January 2010 and December 2012 for inclusion in the modified World Federation of Neurosurgical Societies (mWFNS) scale study. The modified Rankin Scale (mRS) score at discharge and 3 months after onset, prevalence of improvement and decline between these two periods, and their factors were evaluated by age groups through multivariate logistic regression analysis. The rates of improvement and decline were 28.4% and 2.4%, respectively. Factors that improved the mRS score were WFNS and mWFNS scale grade Ⅳ versus (vs.) Ⅰ (odds ratio: 0.47, 95% confidence interval: 0.31–0.71), grade Ⅴ vs. Ⅰ (0.49, 0.31–0.76), and cerebral vasospasm category 4 vs. 1 (0.43, 0.25–0.77). Factors that decreased the mRS score were pre-elderly (65–74 years) vs. non-elderly (<65 years) (5.65, 1.09–29.20), elderly (≥75 years) vs. non-elderly (19.20, 2.36–156.50), WFNS scale grade III vs. I, and aneurysmal location. Mild neurological grade on admission and no cerebral infarction due to cerebral vasospasm were the factors improving outcomes, and aging was a factor declining outcomes between discharge and at 3 months after onset. Careful assessment timing of outcome in elderly patients is needed in the future aging society.
Short-term Effect of Ambient Air Pollutants Change on the Risk of Tuberculosis Outpatient Visits: A Time-series Study in Fuyang, China
Authors: Wang Xin-Qiang , Li Ying-Qing , Hu Cheng-Yang , Huang Kai , Ding Kun , Yang Xiao-Jing , Cheng Xin , Zhang Kang-Di , Yu Wen-Jie , Wang Jie , Zhang Yong-Zhong , Ding Zhen-tao , Zhang Xiu-Jun , Kan Xiao-Hong 
Published: August 2021

Abstract
There is growing evidence that air pollution plays a role in TB, but few studies have comprehensively included the six common air pollutants. Our objectives were to investigate the association between short-term exposure to six common air pollutants and the risk of tuberculosis outpatient visits in Fuyang, China, during the period 2015-2020. We combined the two models to explore the effects of exposure to six air pollutants on the risk of tuberculosis outpatient visits, including Poisson generalized linear regression model and distributed lag non-linear model (DLNM). We performed stratified analyses for season, gender and age. We used the lag-specific relative risks and cumulative relative risk obtained by increasing pollutant concentration by per 10 units to evaluate the connection between six air pollutants and TB, PM2.5 (RR=1.0018, 95%CI: 1.0004-1.0032, delay of 12 days) and (RR=1.0169,95%CI: 1.0007-1.0333, lag 0-16 days), SO2 were 0.9549 (95%CI: 0.9389-0.9712, lag 0 days) and 0.8212 (95%CI: 0.7351-0.9173, 0-20 days lag). Stratified analyses showed that seasonal differences had a greater impact on TB, and male more likely to develop TB than female, older people more likely to develop TB than younger people. Exposure to O3, CO, PM10, PM2.5, and NO2 increases the risk of TB outpatient visits, except SO2 reduces the risk. Male and elderly people should be protected. We need to pay more attention to the impact of seasonal effects on TB.
Landslide Hazard Zonation and Evaluation around Debre Werk Town, North West Ethiopia
Authors: Asmare Dawit , Tesfa Chalachew 
Published: August 2021

Abstract
The present research was conducted in the town of Debre Werk, East Gojjam, North West Ethiopia, with the ultimate aim of conducting a Landslide Hazard Zonation and Evaluation. To reach this aim, the Slope Stability Susceptibility Evaluation Parameter (SSEP) rating system was adopted to zone and evaluate the landslide status of the area. This rating system was done by considering the parameters of intrinsic and external triggering factors that cause landslides. Systematic and detailed fieldwork had been undertaken as a justification. Secondary data, on the other hand, was required to define the general conditions of the area and to gain a thorough understanding of the field of study. Ratings for intrinsic parameters in the SSEP system include slope morphometry, relative relief, slope content, geological structures/discontinuities, land use land cover, groundwater, and external parameters include erosion, seismicity, and manmade activities. Individual facet-wise ratings for intrinsic causative factors and external triggering factors ratings are summarized to evaluate the landslide hazard zonation of an environment. The sum of all causative parameter ratings will give evaluated landslide hazards (ELH). Therefore, the research was carried out by dividing the study area into 70 facets. Then 85 landslide incidents in the study area were investigated. From 85 landslides, 39 districts showed past landslides, 23 showed active landslides and the remaining 23 districts showed signs of landslides. The delineated 70 facets were categorized into 3 landslide hazard zones. There are about 73.3km2 (27.2%) of the study area within the low hazard zone, 140.8km2 (52.1%) within the moderate hazard zone, and the remaining 55.9km2 (20.7%) within the high hazard zone. Based on the findings of SSEP, it can be deduced that the present research area is highly susceptible to landslide and requires special attention during rainy seasons. Finally, the validity of the prepared LHZ map was checked by overlaying the inventory map over the produced LHZ map. The overlap map shows that 17 districts showing active landslides, 2 districts showing signs of landslides, and 5 districts showing past landslide activities fall into high hazard zones. Likewise, 5 districts showing active landslides, 3 districts showing signs of landslides, and 28 districts showing past landslides fall into moderate hazard zones. The remaining 1 district showing active landslides, 18 districts showing signs of landslides, and 6 districts showing past landslide activities fall into moderate hazard zones.
Preliminary Outcomes Following Application Of The Real-Time Navigation System Combined With Intraoperative Three-Dimensional C-Arm Computed Tomography For Zygomatico-Orbital Fracture Reconstruction
Authors: Chu Yu-Ying , Yang Jia-Ruei , Liao Han Tsung , Lai Bo-Ru 
Published: August 2021

Abstract
This study analyzed the outcomes of zygomatico-orbital fracture reconstruction using the real-time navigation system with intraoperative three-dimensional (3D) C-arm computed tomography (CT). Fifteen patients with zygomatico-orbital or isolated orbital/zygoma fractures were enrolled in this prospective cohort. For zygoma reduction, the displacement at five key sutures and the differences between preoperative and intraoperative CT images were compared. For orbital reconstruction, the bilateral orbital volume differences in the anterior, middle, and posterior angles over the medial transitional buttress were measured. Two patients required implant adjustment once after the intraoperative 3D C-arm assessment. On comparing the preoperative and postoperative findings for the zygoma, the average sum of displacement was 19.48 (range, 5.1–34.65) vs. ±1.96 (0–3.95) mm (P < 0.001) and the deviation index was 13.56 (10–24.35) vs. 2.44 (0.6–4.85) (P < 0.001). For the orbit, the mean preoperative to postoperative bilateral orbital volume difference was 3.93 (0.35–10.95) vs. 1.05 (0.12–3.61) mm3 (P <0.001). The mean difference in the bilateral angles at the transition buttress was significantly decreased postoperatively at the middle and posterior one-third. The surgical navigation system with the intraoperative 3D C-arm can effectively improve the accuracy of zygomatico-orbital fracture reconstruction and decrease implant adjustment times.
A randomized, double-blind, placebo-controlled study of liraglutide 3 mg [LIRA 3mg] on weight, body composition, hormonal and metabolic parameters in women with obesity and polycystic ovary syndrome (PCOS)
Authors: Elkind-Hirsch Karen , Chappell Neil , Shaler Donna , Storment John , Bellanger Drake 
Published: August 2021

Abstract
BackgroundThe efficacy of lifestyle modifications for established obesity is limited in women with polycystic ovary syndrome (PCOS) and more aggressive interventions are needed. We assessed the efficacy and safety of the GLP-1 analogue liraglutide 3mg (LIRA 3mg) versus placebo (PL) for reduction of body weight and hyperandrogenism in women with obesity and PCOSMethodsThis randomized, double-blind, placebo-controlled study enrolled women from a single-outpatient center diagnosed with PCOS (NIH criteria) with a body-mass index of at least 30 kg/m.2 Participants were randomly allocated (2:1) to treatment with a subcutaneous injection LIRA 3mg or visually matching placebo, once daily for 32 weeks, plus lifestyle intervention. Study visits at baseline, and 32 weeks included weight, blood pressure (BP), waist (WC) measures and body composition evaluated by dual-energy X-ray absorptiometry (DXA). Oral glucose tolerance tests (OGTT) were done to assess glycemia, mean blood glucose (MBG), and compute insulin sensitivity (SI) and secretion (IS) measures. Sex steroids, free androgen index (FAI), complete metabolic profile and lipid profiles were measured in the fasting sample. Co-primary endpoints were change in body weight (BW) and FAI. Safety was assessed in all patients who received at least one dose of study drug. This study was registered with ClinicalTrials.gov NCT03480022FindingsFrom October 2018 to June 2020, 88 patients were screened, of whom 82 were randomly assigned to LIRA 3mg (n = 55) or PL (n = 27). Change in mean BW from baseline to week 32 was − 5.7% (SE 0·.75) with LIRA 3mg vs. -1.4% (1.09) with PL (P < 0.002). At week 32, more patients on LIRA 3 mg than on placebo achieved weight reductions of at least 5% (25[57%] of 44 vs. 5 [22%] of 23; (p < 0·007). LIRA 3mg resulted in significant reduction of FAI, improvements in SI and IS as well as OGTT MBG, and improved body fat by DXA. Gastrointestinal adverse events, which were mostly mild to moderate, were reported in 32 (58.2%) of 55 patients with LIRA 3mg, and 5 (18.5%) of 27 with PL.InterpretationIn obese women with PCOS, LIRA 3mg once daily achieved a superior and clinically meaningful decrease in BW and androgenicity and improved cardiometabolic parameters compared with placebo.
Pollution Characteristics and Emissions of Typical Organophosphate Esters From a Wastewater Treatment Plant in Chengdu, China
Authors: Yin Hongling , Luo Yi , Song Jiaojiao , Li Shiping , Lin Shuyu , Xiong Yuanming , Fang Shuhong , Tang Juan 
Published: August 2021

Abstract
Effluent from wastewater treatment plants (WWTP) is an important source of organophosphate esters (OPEs) in the receiving rivers. In this paper, the concentration and distribution of seven OPEs in the water samples were determined, and the discharge was estimated. The results showed that the total removal rate of Σ7OPEs in water phase in WWTP was 57.2%. The average concentrations of Σ7OPEs in influent and effluent of the WWTP during rainy period were 3956.1 ± 1897.3 ng/L and 1461.9 ± 846.3 ng/L, respectively, which were about 4 times larger than those in influent water (978.2 ± 166.5 ng/L) and effluent (418.3 ± 12.0 ng/L) during non-rainy period, indicating that rainfall has a marked impact on the load of OPEs in WWTP and the receiving water. It was estimated that the average daily discharge of Σ7OPEs in the effluent of WWTP was 157.9 g, and the daily per capita contribution of the population in the area to the OPEs in the influent was 0.414 mg. During the shift of labour-intensive manufacturing from the coastal developed areas to inland regions, OPEs were widely used and produced in Southwest China. The total amount of OPEs emissions and its control should be taken into consideration.
Tropical cyclone climatology change greatly exacerbates US joint rainfall-surge hazard
Authors: Gori Avantika , Lin Ning , Xi Dazhi , Emanuel Kerry 
Published: August 2021

Abstract
Tropical cyclones (TCs) are among the largest drivers of extreme rainfall and surge, but current and future TC joint hazard has not been well quantified. We utilize a physics-based approach to simulate TC rainfall and storm tides and quantify their joint hazard under historical conditions and a future (SSP5 8.5) climate projection. We find drastic increases in the frequency of exceeding joint historical 100-yr hazard levels by 2100, with a 10–36 fold increase along the southern US coast and 30–195 fold increase in the northeast. The joint hazard increase is induced by sea-level rise and TC climatology change; the relative contribution of TC climatology change is higher than that of sea-level rise for 96% of the coast due to large increases in rainfall. Increasing storm intensity and decreasing translation speed are the main TC change factors that cause higher rainfall and storm tides and up to 25% increase in their dependence.
A Controlled Pre-Post Analysis Investigating The Effect of Mindfulness On Perceived Stress and Cortisol Levels and Exam Performance in Medical Students
Authors: Hearn Jasmine Heath , Stocker Claire J 
Published: August 2021

Abstract
Background.

Medical students demonstrate higher levels of psychological distress compared with the general population and other student groups. Mindfulness interventions show promise in stress reduction for this group, and in the reduction of cortisol, an established clinical marker of the body’s stress response. This study investigated the relationship of mindfulness to perceived stress, salivary cortisol and assessment performance in undergraduate medical students in response to stressful and non-stressful events.
Methods.

A controlled pre-post analysis design with within-groups comparisons. 67 medical students completed the Five Facet Mindfulness Questionnaire (FFMQ) and provided perceived stress ratings and saliva samples, from which cortisol was extracted, during group work (control/baseline) and immediately prior to end of year 2 examinations (experimental). Academic performance data was extracted for comparison with measures.
Results.

Salivary cortisol and perceived stress were significantly increased prior to examinations. The change in cortisol levels from baseline (non-stressful, group work conditions) to experimental (stressful, pre-exam conditions) showed a significant negative correlation with exam performance. FFMQ score showed a significant positive correlation with exam performance and a significant negative correlation with salivary cortisol concentration.
Conclusions.

This study suggests that there exists an important relationship between mindfulness and biomarkers of stress, which may manifest into improved assessment outcomes potentially through healthier, more adaptive coping and stress management strategies. A novel strength of the present study is the identification of individual facets of mindfulness associated with stress and exam performance (acting with awareness and non-judging) suggesting that these may be important targets for improving medical students’ stress management and exam performance.
Complementary hemispheric lateralization of language and social processing in the human brain
Authors: Rajimehr Reza , Firoozi Arsalan , Rafipoor Hossein , Abbasi Nooshin , Duncan John 
Published: August 2021

Abstract
Humans have a unique ability to use language for social communication. The neural architecture for language comprehension and production may have emerged in the brain areas that were originally involved in social cognition. Here we directly tested the fundamental link between language and social processing using functional MRI data from over 1000 human subjects. Cortical activations in language and social tasks showed a striking similarity with a complementary hemispheric lateralization; within core language areas, the activations were left-lateralized in the language task and right-lateralized in the social task. Outside these areas, the activations were left-lateralized in both tasks, perhaps indicating multimodal integration of social and communicative information. Our findings could have important implications in understanding neurocognitive mechanisms of social disorders such as autism.
Double grazing bifurcations of the non-smooth railway wheelset systems
Authors: Miao Pengcheng , Li Denghui , Yin Shan , Xie Jianhua , Grebogi Celso , Yue Yuan 
Published: August 2021

Abstract
There are numerous non-smooth factors in railway vehicle systems, such as flange impact, dry friction, creep force, and so on. Such non-smooth factors heavily affect the dynamical behavior of the railway systems. In this paper, we investigate and mathematically analyze the double grazing bifurcations of the railway wheelset systems with flange contact. Two types of models of flange impact are considered, one is a rigid impact model and the other is a soft impact model. First, we derive Poincaré maps near the grazing trajectory by the Poincaré-section discontinuity mapping (PDM) approach for the two impact models. Then, we analyze and compare the near grazing dynamics of the two models. It is shown that in the rigid impact model the stable periodic motion of the railway wheelset system translates into a chaotic motion after the gazing bifurcation, while in the soft impact model a pitchfork bifurcation occurs and the system tends to the chaotic state through a period doubling bifurcation. Our results also extend the applicability of the PDM of one constraint surface to that of two constraint surfaces for autonomous systems.
Yttria- Stabilized Tetragonal Zirconia with Superior Mechanical Properties Prepared Using Gel Casting Technology and a Two-Stage Sintering Process
Authors: Jhan Jing-Siang , Chen Chih-Cheng , Liu Yu-Chi , Hsiang Hsing-I 
Published: August 2021

Abstract
Yttria-stabilized tetragonal zirconia (YTZP) ceramics with high densification and superior mechanical properties were obtained using gel casting technology and a two-stage sintering process. Well-dispersed Nano-sized (94 nm) zirconia slurry with high solid content (45vol%) was prepared for gel casting using Dolapix CE64 as the dispersant. As the dispersed slurry was added epoxy monomer (EGDGE) and polymerization initiator (DPTA), Dolapix CE64 promoted gelling, leading to an abrupt increase in the slurry viscosity. As Dolapix CE64 was added into the slurry, its functional carboxyl groups reacted with EGDGE, resulting in a decrease in gelling incubation time and an increase in viscosity, hence, leading to gel casting failure. The addition of hydroquinone (HQ) into the slurry can be used to delay the polymerization and extend the gel casting working time. After gel casting, the temperature was raised to above 60o C to promote the polymerization, leading to an increase in the green strength.A two-stage sintering process was used to control the grain growth. The first stage sintering temperature was chosen at 1300oC, where the relative density reached 83%. In the second sintering stage, the temperature was lowered to 1240°C and soaked for 24 h to inhibit grain growth (mean grain size of 195 nm) and continue densification to a relative density of above 99%. Vickers hardness of 15.2GPa, fracture toughness of 7.8MPa.m1/2, and flexural strength of 771MPa can be obtained for the sample prepared using gel casting technology with a two-stage sintering process.
Hsa-miR-3120/miR-214 Mirror miRNAs Alteration in Colorectal Cancer
Authors: Bahonar Sajedeh , Soltani Bahram Mohammad , Jafarzadeh Meisam 
Published: August 2021

Abstract
Colorectal cancer is one of the most common cancers, and various studies have shown that many genes, including miRNAs, play important roles in the development of this cancer. Here, we investigated the molecular and cellular effect of miR-3120 and its mirror miRNA, miR-214, in colorectal cancer using bioinformatics and experimental techniques. Microarray data analysis showed that miR-3120/miR-214 expression are deregulated in colorectal cancer tumors and RT-qPCR analysis of these miRNAs showed a negative expression correlation in different colorectal cancer-originated cell lines. Also, RT-qPCR result indicated that miR-3120 and miR-214 affects each other expression. Overexpression of miR-3120 in HCT-116 cell line followed by qRT-PCR showed increased expression of SMAD3, SMAD4 and AKT2 genes, whereas overexpression of miR-214 inversed this effect. In addition, the expression of specific target genes of each microRNA showed a pattern of co-expression with its microRNAs. Also, investigating the effect of miR-3120/miR-214 on the cell cycle, showed their promoting effect on the progression of the cell cycle. Overall, these data suggest that miR-3120/miR-214 may be involved in regulating the molecular pathways of colorectal cancer, and part of this regulation could be related to the interaction of these genes with each other.