bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Establishment of a Finite Element Model and Biomechanical Analysis of Different Fixation Methods for Total Talar Prosthesis Replacement
Authors: yang qian dong , Le Chang , Wan Chen , Xuting Bian , Lin Ma , Xu Tao , Kanglai Tang 
Published: November 2021

Abstract
Background: As a new technology, three-dimensional (3D)-printed personalized talar prostheses are associated with different fixation methods for implanted prostheses, including fixing the subtalar joint and talus-navicular joint with screws and fixing the subtalar joint with screws only and fixation without screws. No biomechanical study has been conducted yet. we aimed to build a 3D finite element model to compare the biomechanical effects of different fixation methods.Methods: With 3D CT and MRI data of a volunteer's foot, Mimics research 19.0 and Geomagic wrap 2017 software were used to complete the geometric reconstruction of bone and cartilage, which was then input to NX12.0 software to build finite element models with different fixation methods. Finally, the models were imported into Abaqus 6.14 software for meshing and assigning material properties and the different biomechanical effects in three gait phases (heel-strike, midstance and push-off) were simulated. The pressure changes in the articular surface around the talus or the prosthesis, the micromotion of the talus and the prosthesis and ankle motion were measured.Results: The 3D finite element model created in this study has been verified to be consistent with previous studies.Finite element analysis of the biomechanical mechanism showed that screw fixation of the prosthesis in different gait phases mainly increased the pressure on the tibia-talus articular surface and decreased the pressure on the fused articular surface and joint micromotion, which hindered ankle motion. The indicator values were nearly the same in the models of fixation without screws and the healthy state.Conclusions: The biomechanical mechanism varies by fixation method according to the finite element analysis. Fixation of the prosthesis without screws yields values most similar to healthy values.Trial registrationThis study was approved by the institutional review board ethics committee of the Southwest Hospital Affiliated with the Army Medical University (No. ECFAH2006051)
Impact of Early Palliative Care on End of Life in Advanced Biliary Tract Cancer Patients
Authors: Miralles Margaux , Borg Christophe , Manfredi Sylvain , Minello Anne , Bouché Olivier , Tambou Marlène , Mutter Didier , Chiappa Pascale , Kurtz Jean-Emmanuel , Luc Amandine , Baumann Cedric , Lopez Anthony 
Published: November 2021

Abstract
Background: Majority of biliary tract cancer (BTC) patients have not access to surgery. They receive chemotherapy and/or palliative care (PC). We studied if early palliative care referral could influence overall survival (OS) and the aggressiveness of end-of-life care. Participants and Design: We conducted a retrospective cohort study in patients with non-curative BTC, diagnosed between 2013 and 2019 in 6 hospitals of Eastern France. PC was defined a specialist-delivered palliative care encounter.Results: 200 patients with BTC were included in our study, with 188 deaths. 87 (44%) had no PC, 30 (15%) had a very early PC (<3 months after diagnosis), 20 (10%) had an early PC (3-6 months), and 63 (32%) a late PC (>6 months). The median time between referral and death was 0.9 to 1.3 months (depending on groups). OS were 12.4 months (no PC), 3.0 months (PC<3 m), 6.4 months (PC 3-6 m), 16 months (PC>6 m). We had no evidence for survival improvement with early PC. PC seemed to reduce chemotherapy near death (37% without PC, 30% with PC<3m, 11% with PC 3-6m, 10% with PC>6m), visits in emergency department (ED) during final month (respectively: 36%, 20 %, 15%, and 7%), intensive care unit hospitalizations (ICU) near death (13%, 0%, 0%, 2%). Place of death seemed to be positively impacted by PC (conventional acute unit, respectively: 73%, 21%, 21%, 25% and ICU or ED: 8%, 0%, 5%, 2%).Conclusion: Referral to PC seems too late for changing disease course. Our practice should evolve, with the objective that each advanced BTC patient has early-PCR after diagnosis, for improving management of end-of-life, symptoms, and family needs. Trial registration number: 2019PI274 , 05/28/2020.
Profiling of microRNAs Targeting Survivin in the Iranian Patients with Colorectal Cancer
Authors: Chavoshi Hadi , Bornehdeli Soghra , Asadi Milad , Dolatkhah Roya , Shanehbandi Dariush , Raeisi Mortaza 
Published: November 2021

Abstract
Background: Survivin is involved in the apoptosis of cells. Impaired levels of survivin have been associated with increased survival of tumor cells. In this study, we intended to profile the microRNAs (miRNAs) targeting survivin in the tumoral and marginal tissues obtained from Iranian patients with colorectal cancer (CRC). Methods and Materials: Fifty CRC patients with Iranian Azari ethnicity were recruited. The RNA content of the tumoral and marginal tissues was isolated and the transcript levels of miR-34a, miR-16, miR-150, and miR-203a and survivin were determined through quantitative Real-time PCR. Results: The mRNA expression of survivin was significantly increased (fold change= 3.21, P= 0.0029) in the tumoral tissues in comparison to the marginal tissues. There was significant downregulation of miR-16 (fold change= 0.28, P= 0.003) and miR-203a (fold change= 0.36, P= 0.014) in the tumoral samples in comparison to marginal samples. There was an inverse significant correlation (rho= -0.81; P< 0.001) between expression of miR-203a and mRNA expression of survivin in the tumoral tissues from CRC patients. The mRNA expression of survivin was higher significantly in the tumoral tissues from CRC patients with lymph node metastasis in comparison to those without lymph node metastasis (P= 0.020). In addition, there was significantly higher miR-203 expression level in the tumoral tissues from CRC patients with lymph node metastasis in comparison to those without lymph node metastasis (P=0.011).Conclusion: It is suggested that miR-203 play an oncogenic role in CRC cancer by regulating survivin and lymph node metastasis.
Efficacy and Safety of Deep Acupuncture at Qugu Point (CV2) for Benign Prostatic Hyperplasia: Study Protocol for a Randomized Controlled Trial
Authors: Tang Han , Lu Yonghui , Ren Hua , Fu Jianhua , Meng Yulian , Li Baoying , Lu Fang , Song Xinzi 
Published: November 2021

Abstract
Background: Benign prostatic hyperplasia (BPH) is one of the most common urological disease and often associated with lower urinary tract symptoms (LUTS) in elderly men. Chinese acupuncturists found that deep acupuncture at Qugu point (CV2) can effectively relieve urination difficulties and improve quality of life of patients with troublesome BPH/LUTS. However, there are currently insufficient scientific evidence and well-designed trials to support its effect as well as safety in the treatment of BPH/LUTS. Therefore, this study protocol is designed to evaluate the effectiveness and safety of deep acupuncture at CV2 for men with BPH/LUTS.Methods: A single-center, randomized, subject-and assessor-blinded, placebo-controlled trial will be conducted in an outpatient acupuncture department in Beijing, China. A total of 120 subjects (50-80 yr) will be randomized to one of three balanced groups: deep acupuncture group 1 (deep acupuncture at CV2 with needle tip reaching the prostate capsule), deep acupuncture group 2 (deep acupuncture at CV2 with needle tip 10mm away from the prostate capsule), and sham acupuncture group (sham acupuncture with non-penetrating needle) in a ratio of 1:1:1. The study period for each subject will be 4 months, including 4 weeks baseline observation period, 4 weeks intervention period, and 8 weeks follow-up period. All subjects will receive 10 treatments during the intervention period. Subjects in deep acupuncture groups will be measured the needle depth and angle by computerized tomography (CT) in their first treatment. The primary outcome is the change in International Prostate Symptom Score. Secondary outcomes include quality of life, maximum urinary flow rate, and post-void residual.Discussion: The objectives of this study include: 1) to assess the efficacy of deep acupuncture at CV2 in the treatment of BPH; 2) to evaluate the safety of acupuncture at CV2 by measure the needle depth and angle under CT. This study will provide an evidence-based recommendation for acupuncture at CV2 in the treatment of BPH.Trial registration: Registered on 18 January 2020. Chinese Clinical Trials Register, ChiCTR2000029203.
Study on the Emission Characteristics and Mechanism of Sulfur-Containing Gas During Sludge Pyrolysis at Low Temperatures
Authors: Shang Shuo , Fan Haihong , Li Binbin , Li Lin , Li Zhou 
Published: November 2021

Abstract
In order to explore the influence of the release of sulfur-containing gases in the process of sludge pyrolysis, temperature, time and calcium-based conditioner were selected to conduct low-temperature sludge pyrolysis experiment on sludge, and effective measures to control the release of sulfur-containing gases such as CS2, H2S and SO2 were proposed. The experimental results show that when the temperature is below 200℃, the release of H2S gas is less than 50 µg/g. The release amounts of C2S and H2S within 3min were 20.84µg/g and 339.42µg/g, respectively. Combined with the release characteristics of the three gases, it was concluded that the drying temperature of the sludge was controlled below 250℃ and the drying time was controlled within 1 min. The concentration of sulfur-containing gas is 59.81 mg/m3, 94% lower than that of dry pure sludge gas when the addition of calcium base powder is 20% of the original sludge mass fraction. After absorption of calcium base powder, there are almost no organic compounds containing sulfur and sulfur gas. The research results provide a direction for the selection of pyrolysis sludge treatment process, which is beneficial to control the discharge of harmful gases.
Impact of A Simulation-Based Training on Self Assessed Nursing Performance in Anaphylactic Shock Management: A Pre-Post Educational Intervention Study
Authors: Ren Qi , Chen Fang , Zhang Huijuan , Tu Juanhua , Xu Xiaowei , Liu Caixia 
Published: November 2021

Abstract
Background

The New Nurses who lack the ability to recognize and manage anaphylactic shock can endanger the patients. In this study, we explored the effect of a simulated scenario designed to improve nurses’ understanding of their roles and responsibilities during the rescue of a patient with anaphylactic shock.
Methods

The program of a simulation-based training was designed to teach learners to recognize the signs and symptoms of anaphylactic shock, place the patient in the correct position, stop ongoing intravenous infusion of the antibiotic which trigger the anaphylactic shock, restart an intravenous infusion on a new infusion apparatus, give 100% oxygen via a nasal cannula or mask, preserve airway patency, call the rapid response team (RRT), and correctly administer the medications prescribed by the clinician. Instructors evaluated each learner’s skills and behaviors by using a clinical competency questionnaire. All learners then completed the Chinese version of the Simulation Design Scale (SDS) and participated in semi-structured interviews with their instructors after the training.
Results

All learners showed significant improvements in the 6 competencies assessed by the clinical competency questionnaire after the simulation-based training (all P<0.001). Scores on the SDS revealed that the learners were highly satisfied with all aspects of the simulation-based training (the 20 satisfaction rates were all above 90.00%). During the semi-structured interviews, new graduated nurses reported that simulation-based training in the management of anaphylactic shock was extremely important and would guide them in clinical practice.
Conclusions

The simulation-based training in anaphylactic shock is a potentially viable and effective method to teach new registered nurses to manage clinical incidents.
Hemodynamic Characteristics of Dilated Ascending Aorta in Patients with Bicuspid Aortic Valve
Authors: Zheng Tie , Lu Shijie , Zhu Shuai , Ou Jiafu , Zhu Jun-Ming 
Published: November 2021

Abstract
Objective: Aim of this study is to investigate the influence of aortic diameter on hemodynamic environment characteristics in patient with the bicuspid aortic valve (BAV) and dilated ascending aorta (AAo) .Methods: In this study, an MRI of one BAV patient with 4.5 cm AAo was collected and numerical model was constructed. Based on the images，the other three numerical models were constructed with different ascending aortic size with 4.0cm, 5.0cm and 5.5cm respectively while the size and the geometry of other parts were fixed. Then hemodynamics in these four models was simulated numerically and the flow patterns and loading distributions were investigated.Results: Hemodynamics environments in the AAo were simulated with different aortic size. As the aortic diameter increases, we find: 1. the blood flow becomes more disturbing;2.the wall pressure at ascending aortic is higher; 3. the wall shear stress at the ascending aortic decreases; 4.oscillatory shear index of the outer part on the proximal AAo increases;5. all these hemodynamic parameters described above are asymmetrically distributed in dilated AAo and more parts of aorta would be affected as the AAo dilatation progresses.Conclusions: The study revealed that the diameter of ascending aortic can significantly influence the magnitude and distribution of the dynamics. There are altered flow patterns, pressure difference, WSS and OSI distribution features in bicuspid aortic valve patients with vascular dilatation. As the extent of aortic dilatation increases especially exceed 5.5cm,this study support the recent guideline that aortic replacement should be considered .
Valorization of The By-Products of Poultry Industry (Bones) By Enzymatic Hydrolysis and Glycation to Obtain Antioxidants Compounds
Authors: Zapata Luisa María Londoño , Cardona Sara Franco , Manotas Sandra Patricia Restrepo , Narváez Fáver Gómez , Restrepo Lina Marcela Suárez , Andrade Helena Nuñez , Araya Pedro Valencia , Simpson Ricardo , Castro Óscar Vega 
Published: November 2021

Abstract
Currently, one of the fastest growing industries in the world is the poultry industry; however, the increase in demand has generated the production of various byproducts, such as bones, and these byproducts have a negative impact on the environment. The aim of the present work was to evaluate the effect of glycation on the increase in antioxidant compounds and the formation of indicators of advanced glycation end products (AGE) in chicken bone hydrolysates; it also aimed to maximize the protein content, degree of hydrolysis and antioxidant content. Through analysis of variance (ANOVA), the content of AGE products (HMF and furfural) formed in the glycation process was analyzed. The chicken bone hydrolysate (CBH) had a protein content of 1.42 g/l, a degree of hydrolysis of 17.2% and an antioxidant capacity of 8334 and 10343 μmol ETrolox/l according to ABTS and ORAC evaluations, respectively. The glycation process increased the ORAC by 6.57%. The presence of hydroxymethylfurfural and furfural was determined in the glycated samples and detected at values between 0.05 and 0.22 and 0 and 0.26 ppm, respectively. In conclusion, hydrolysis and glycation are suitable alternatives that enable the use of chicken bones in producing food ingredients with higher added value.
Phosphorous Containing poly(amidoamine-organosilicon) (P@PAMAMOS) Flame Retardants: Synthesis and Sol-gel Application on Cotton Fabrics
Authors: Zhang Zhen , Li Jin lan , Zhou Chang nian , Sun Jie 
Published: November 2021

Abstract
A novel hyperbranched phosphorous containing poly(amidoamine-organosilicon) (P@PAMAMOS) was successfully synthesized and the structure was characterized using Fourier transform infrared spectra (FT-IR), 1H NMR and 31P NMR. The cotton fabrics was grafted with P@PAMAMOS by sol-gel methods. The results of P@PAMAMOS modified cotton fabrics were proved by FT-IR and scanning electron microscopy (SEM). The thermal degradation of blank cotton fabrics and P@PAMAMOS modified cotton fabrics were probed by thermogravimetric (TG) analysis, the phenomenon showed that modified cotton fabrics has exquisite thermal stability, when the temperature reached 700℃，the char residues of A10 treated cotton, B10 treated cotton, C10 treated cotton were 29.5%, 34.5%, 28.8%, respectively. The combustion properties of cotton fabrics were tested by limiting oxygen index (LOI) and vertical burning test. The untreated cotton fabrics was completely burned and the LOI value reached 18.0%, however the char diameter of 20wt% P@PAMAMOS modified cotton fabrics was reduced 3.2 cm and LOI value increase to 31.2%, this means that P@PAMAMOS modification shows desirable flame retardancy.
Effects of Immune Response and Time Delays in Models of Acute Myeloid Leukaemia
Authors: Sun Weigang , Yang Lei , Luo Min 
Published: November 2021

Abstract
In this paper, we propose a general acute myeloid leukaemia (AML) model and introduce an immune response and time delays into this model to investigate their effects on the dynamics. Based on the existence, stability and local bifurcation of three types of equilibria, we show that the immune response is a best strategy for the control of the AML on the condition that the rates of proliferation and differentiation of the hematopoietic lineage exceed a threshold. In particular, a powerful immune response leads to bi-stability of the steady states, and a stronger response wipes out all the leukaemia cells. In addition, we further reveal that the time delays existing in the feedback regulation and immune response process induce a series of oscillations around the steady state, which shows that the leukaemia cells can hardly be eliminated. Our work in this paper aims to investigate the complex dynamics of this AML model with the immune response and time delays on the basis of mathematical models and numerical simulations, which may provide a theoretical guidance for the treatments of the AML.
Down-regulation of Risa Improves Podocyte Injury by Enhancing Autophagy in Diabetic Nephropathy
Authors: Su Peipei , Liu Dongwei , Zhou Sijie , Chen Hang , Wu Xianming , Liu Zhangsuo 
Published: November 2021

Abstract
BackgroundLncRNA AK044604 (Risa), Sirt1 and GSK3β are autophagy related genes that can play important roles in diabetic nephropathy (DN). In this study, we sought to explore the effect of Risa on Sirt1/GSK3β-induced podocyte injury.MethodsTransgenic db/db mice were fed and injected with Risa inhibition of adeno-associated virus by tail vein injection, as well as intraperitoneally injected with LiCl. Blood, urine, kidney tissue samples, and clinical data were collected at different time points. Immortalized mouse podocyte cells (MPCs) were cultured and treated with Risa inhibition of lentivirus, EX-527, and LiCl. MPCs were collected under different stimulations. The effects of Risa on podocyte autophagy were examined by qRT-PCR, Western blot analysis, transmission electron microscope, PAS staining, and immunofluorescence staining. ResultsRisa and activated GSK3β were overexpressed, but Sirt1 decreased in Renal tissues of DN mice and high-glucose-treated MPCs and correlated with poor prognosis. Risa overexpression attenuated Sirt1-mediated downstream autophagy levels and aggravated the injury of podocytes by inhibiting the expression of Sirt1. In contrast, Risa inhibition enhanced Sirt1-induced autophagy and attenuated podocyte injury, but this effect could be abrogated by EX-527, suggesting that Risa overexpression aggravated podocyte injury by decreasing autophagy. ConclusionsRisa inhibits autophagy by regulating the Sirt1/GSK3β axis and thereby aggravates podocyte injury in DN. Risa may serve as a therapeutic target for the treatment of DN.
Enhanced Spring Warming in a Mediterranean Mountain:In Quest for Multi Causalities
Authors: Rambal Serge , Bruley Enora , Mouillot Florent , Lauvaux Thomas 
Published: November 2021

Abstract
We analyzed trends of air temperature across the Cévennes National Park in Southern France, a mid-altitude coastal mountain experiencing a rapid spread of forests at the expense of rangelands and submitted to Mediterranean Sea influences and so, impacted by local and regional processes of climate change. Since 1980, April to June warming trend reached a maximum temperature increase of +0.124°C year−1 and uniform whatever the altitude. Minimum temperature increased by +0.058°C year−1 at 500 m altitude and +0.089°C year−1 at 1500 m. Concomitantly, forest cover is increasing by +0.51% year−1. Using an intrinsic biophysical mechanism model, we demonstrated that, at monthly scale, the forest surface is 1.7–3.1°C cooler than that of nearby grasslands. As a result, the decrease in albedo corresponding to the conversion from grasslands to dense forests, translates into a cooling of maximum air temperatures of 0.023°C year−1 which contributes to slow down the warming rate enhancement. Spring warming trends co-varied with negative WeMO phases associated with a low in the Gulf of Cádiz and an anticyclone in Central Europe. An east to west pressure gradient increases atmospheric humidity leading to a strong water vapor feedback, enhancing the forcing of thermal long wave radiations and hence the rise in temperature.
Environmentally Friendly Pyrometallurgical Scheme for Vacuum Separation of Non-Ferrous Metals from Waste Products in Incineration Plants
Authors: Trebukhov Sergey , Volodin Valeriy , Ulanova Olga , Nitsenko Alina , Tuleutay Farkhat 
Published: November 2021

Abstract
Residues from the municipal solid waste processed in incineration plants in European countries are an important raw material to obtain valuable components, including non-ferrous metals. State and private companies specializing in the processing of waste incineration slag as products most often receive concentrates of non-ferrous metals, which, on average, contain, in mass. %: 20÷60 Cu; 10÷30 Zn; 5÷15 Pb; ~ 1 Al; ~ 1 Sn; ~ 1 Fe, up to 50 g/t Аu and up to 3,000 g/t Ag. Concentrates are sent for processing to smelters without taking the cost of zinc into account. The paper presents the study on the separation of metallic zinc into a separate product (zinc concentrate) from the collective concentrate of non-ferrous metals by a vacuum-thermal method, the safest from the environmental point of view. The study was performed with non-ferrous metal concentrate of +0.3-0.8 mm in size, containing wt. %: 68.07 - Cu; 12.4 - Zn; 14.78 - Pb; 0.99 - Al; 1.2 - Sn; 0.15 - Fe, up to 2.0 kg/t - Ag. The material was heat treated at 800÷900℃ with the residual pressure in the system of less than 0.13 kPa. Zinc concentrate was obtained, containing more than 96% of the main component. At the same time, the Cu content increased by 14.09% in the residue from the heat-vacuum treatment. Other metals (Pb, Al, Sn) including noble metals were also concentrated in the residue. The results of the study show that it is possible to separate zinc into a separate product from non-ferrous metal concentrates containing more than 10% Zn in the initial material by the proposed method.