bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Positive Events Recording Based on Positive Psychology on Healthy Behaviours and Readmission Rate of Patients After PCI: A Study Protocol for a Prospective, Randomized Controlled Trial
Authors: Hu Yao yao , Jiang Xin , Mao Fang ying , Zhang Jing , Liu Lin , Gu Jie , Wu Qing , Wu Yin 
Published: June 2021

Abstract
Background: Unhealthy behaviours of coronary heart disease (CHD) patients are closely related to the occurrence of major heart events, which increases the readmission rate and brings heavy economic burden to families and society. Therefore, it is necessary for health care workers to take active preventive and therapeutic measures to keep or establish healthy behaviours of patients. Positive psychological intervention has been proved to be effective, but it has not been reported in the field of CHD in China. The purpose of this study is to explore the effects of positive events recording based on positive psychology on the healthy behaviours, readmission rate and anxiety of patients with CHD, in order to provide new ideas for the development of secondary prevention strategies for CHD.Methods: This is a prospective, single-center, randomized controlled trial (RCT). The subjects will be enrolled from the Department of Cardiology, the First Affiliated Hospital of Soochow University. There are 80 cases in total, according to the random number table, the subjects are randomly divided into the intervention group (n=40) and the control group (n=40). The patients in the intervention group will receive the intervention of recording positive events once a week for 3 months, while the patients in the control group receive conventional nursing, and each group will be followed up for 6 months. The primary outcomes will include healthy behaviours, readmission rate and anxiety, the secondary outcomes will include psychological capital, subjective well-being and corresponding clinical laboratory indicators. The protocol was approved by the Medical Ethics Committee of Soochow University (approval No. SUDA20200604H01) and is performed in strict accordance with the Declaration of Helsinki formulated by the World Medical Association. All participants provide written informed consent.Discussion: This study will verify whether positive events recording based on positive psychology can make patients maintain healthy behaviours, reduce readmission rate and improve anxiety after PCI. Then, this study will provide new ideas and references for the development of secondary prevention strategies for patients with CHD. Trial registration: Chinese Clinical Trials Registry, 2000034538. Registered on 10 July 2020.
Ocular Vogt-Koyanagi-Harada: Is it the era of diagnosis by OCT?
Authors: Elubous Khaled , Farah Mohammed S. , Shokry Ahmed N. , Abu-Ameereh Mohammed 
Published: June 2021

Abstract
PURPOSE to report optical coherence tomography (OCT) changes of the retina during acute and recovery phases in a patient with atypical Vogt-Koyanagi-Harada (VKH) disease presented for the first time with ocular symptoms and role of (OCT) in the diagnosis, following and assessing response to treatment.Methods Ophthalmologic examination, laboratory evaluation, fluorescein angiography, and spectral-domain optical coherence tomography performed on a twenty-four-year-old female presented with a bilateral blurring of vision of 3 days.ResultsOCT disclosed multifocal subretinal lobulated cystic fluid collections with thickening and hyper-reflectance in outer retinal layers. Decreased retinal thickness and resolving subretinal fluid collections were seen after commencing treatment by systemic corticosteroids. Conclusion OCT is a very sensitive tool to diagnose and monitor the highly detailed retinal changes during the VKH course especially if presented primarily with ocular symptoms
A 'Hands on' Public Service Program to Help People Stay Sober and Safer on the Roadway
Authors: Andrews Jessica , Shareef Zanab , Mohammed Mohammed , Nwobi Edison , Masri-zada Tariq , Head Tyiesha , Zohr Tylor , Head Doreen , Commissaris Randall 
Published: June 2021

Abstract

Background. Despite the existence of many different “Don’t drink and drive” programs and campaigns over the past 30 years, alcohol intoxication has continued to account for approximately one quarter to one third of all traffic crashes and crash-related deaths in the United States. The present study describes a new ‘hands on’ evidence-based approach involving real alcohol-intoxicated subjects using a virtual reality (VR) driving ‘game’ to educate the public more effectively about the dangers of drunk driving. Method. A single demonstration subject ‘drove’ a VR-based portable driving simulator on multiple occasions before (Pre) and at 30 minute intervals for up to six hours after either vehicle (no alcohol), 2, 4 or 6 ‘drinks’ (3, 6, or 9 ounces of 80 proof vodka). The defensive driving task was a choice reaction crash avoidance steering maneuver in which the driver’s task was to determine which way to turn to avoid a crash and then aggressively steer away to avoid a crash. The primary dependent variable was the latency to initiate an avoidance steering response. BAC determinations (estimations) were conducted immediately prior to driving tests using BAC Track portable breathalyzers.Results. Control drives (Pre-Treatment and Vehicle treatment) were characterized by an approximately 300-320 msec reaction time to initiate a crash avoidance. Alcohol increased crash-avoidance reaction time. Peak BAC values were 35, 78 and 120 mg/dl for 2,4 and 6 drinks, respectively; the decline in BAC was comparable and linear for all three treatments. There was a strong correlation (r=0.85) between pre-drive BAC level and reaction time across all of the alcohol-related drives. There was a significant increase in crash avoidance reaction time when the BAC was 50-79 mg/dl, which is below the legally-defined BAC limit (80 mg/dl) currently used in most states in the US.Conclusions. These results demonstrate (1) this VR-based driving simulator task could be a useful ‘hands on’ tool for providing public service demonstrations regarding the hazards of drinking and driving and (2) a BAC concentration of 50 mg/dl represents a reasonable evidence-based cut-off for alcohol-impaired driving.
The Way to a Man’s Heart Is Through His Stomach: a Case of Myocardial Infarction Mimic and Pseudo-tamponade in a Polytrauma Patient.
Authors: Brun Mathew , Brun Shane , Pearson David , Wullschleger Martin 
Published: June 2021

Abstract
Background: There exists a therapeutic conflict between haemorrhage control and prevention of thromboembolic events following polytrauma and complications are not uncommon. Such opposing therapies can result in unexpected pathophysiology and there is a real risk of misdiagnosis resulting in harm. This case presents a previously unreported complication of prevention and management of thromboembolism- STEMI (ST elevation myocardial infarction) and tamponade mimic secondary to retroperitoneal haematoma.Case presentation: We present a 50-year-old male polytrauma patient who following treatment for presumed pulmonary embolus demonstrated classical clinical findings of myocardial infarction and pericardial tamponade secondary to a retroperitoneal haematoma. This is an event not previously reported in the literature. The risk of adverse outcome by management along the standard lines of STEMI (ST elevation myocardial infarction) was averted through awareness for alternative aetiology via a multi-team approach which resulted in percutaneous drainage of the haematoma and complete resolution of symptoms.Conclusions: This manuscript highlights the therapeutic conflict between haemorrhage control and prevention of thromboembolic events in critically injured, the importance of high index of suspicion in this patient cohort and the benefits of multidisciplinary decision making in the complex patient through a not previously published pathophysiologic phenomenon.
Modelling Impacts of Lateral N Flows And Seasonal Warming on an Arctic Footslope Ecosystem N Budget and N2O Emissions Based on Species-Level Responses
Authors: Rasmussen Laura Helene , Zhang Wenxin , Ambus Per , Jansson Per-Erik , Kitzler Barbara , Elberling Bo 
Published: June 2021

Abstract
Future Arctic tundra primary productivity and vegetation community composition will partly be determined by nitrogen (N) availability in a warmer climate. N mineralization rates are predicted to increase in winter and summer, but because N demand and –mobility varies across seasons, the fate of mineralized N remains uncertain. N mineralized in winter is released in a “pulse” upon snowmelt and soil thaw, with the potential for lateral redistribution in the landscape. In summer, the release is into an active rhizosphere with high local biological N demand. In this study, we investigated the ecosystem sensitivity to increased lateral N input and near-surface warming, respectively and in combination, with a numerical ecosystem model (CoupModel) parameterized to simulate ecosystem biogeochemistry for a tundra heath ecosystem in West Greenland. Both model and measurements indicated that plants were poor utilizers of increased early-season lateral N input, indicating that higher winter N mineralization rates may have limited influence on plant growth and carbon (C) sequestration for a hillslope ecosystem. The model further suggested that, although deciduous shrubs were the plant type with overall most lateral N gain, evergreen shrubs had a comparative advantage utilizing early-season N. In contrast, near-surface summer warming increased plant biomass and N uptake, moving N from soil to plant N pools, and offered an advantage to deciduous plants. Neither simulated high lateral N fluxes nor near-surface soil warming suggests that mesic tundra heaths will be important sources of N2O under warmer conditions. Our work highlights how winter and summer warming may play different roles in tundra ecosystem N and C budgets depending on plant community composition.
Pancytopenia Secondary to SARS-CoV 2 Infection-A Case Reprt
Authors: Sharma Neeraj , Shukla Rajat , Warrier Rachna , Kumar Kunal , Singh Nalin , Ghose Sourav , Kumar Vivek 
Published: June 2021

Abstract
Pancytopenia is a condition when person has low count of all three types of blood cells causing a triage of anemia, leukopenia and thrombocytopenia. It should not be considered as a disease in itself but rather the sign of a disease that needs to be further evaluated. Among the various causes, viral infections like Human Immunodeficiency Virus, Cytomegalovirus, Epstein-Barr virus and Parvovirus B19 have been implicated. Pancytopenia is a rare complication and not commonly seen in patients with COVID 19 disease. Here, we report a case of pancytopenia in previously immunocompetent elderly male patient with SARS-CoV2 infection.
Development and construct validation of a questionnaire for measuring affordances for motor behavior of schoolchildren
Authors: Flôres Fábio Saraiva , Rodrigues Luis Paulo , Cordovil Rita 
Published: June 2021

Abstract
Environments where children move about provide affordances that play a significant role in their development. This research presents the Affordances for Motor Behavior of Schoolchildren (AMBS) assessment tool, which aims to assess the interdependent systems, such as home, school, and sports activities, that can influence 6 to 10-year-old children's motor development, motor learning, and motor competence. After establishing face validity, 259 south Brazilian families completed the questionnaire. We assessed construct validity on the whole sample with Confirmatory Factor Analysis. The model testing showed a very good fit, and the structural model presented significative loading coefficients from the identified variables to the theoretically specified latent variables (factors). Significant correlation values were found between factors: Home and Materials (r = 0.77), Home and School (r = 0.41), and Materials and School (r = 0.56). Our results suggest that the AMBS can assess the opportunities for action provided to children by their home, the materials in it, and their school.
Current Situation of Clinical Trials of Drugs for Children's Indications in China
Authors: Song Lin , Ran Sujuan , Jia Yuntao , Li Bin , Xu Jin , Huo Bennian , Yin Nange , Ai Maolin , Liu Yao 
Published: June 2021

Abstract
Background: The number of pediatric outpatient visits in the general hospitals of China shows an increasing trend year by year. To analyze the current situation of clinical trials of drugs with indications for children in China in order to provide references for research and development of drugs for children and in formulating relevant policies. Methods: Drug clinical trials with indications for children registered before January 9, 2020 were retrieved based on the drug clinical trial registration and information publicity platform. The data were extracted and statistically analyzed by excel 2010 and SPSS 22.0, respectively. Results: There were 256 clinical trials of drugs with indications for children, which accounted for 2.61% of the total registered trials. The overall average annual growth rate of the number of trials from 2007 to 2019 was 43.30% (P=0.0000). The host company and the lead organization were mainly located in the eastern and northern parts of China. There were 67 trials (26.17%) with children as subjects; 102 trials (39.84%) with research drugs only for children; the drug type was mainly the chemical drug, and indications mainly included infections, nervous and mental diseases and respiratory diseases. Conclusion: The prospects associated with pediatric drug development are positive, but it still needs new incentives or technical guidance to further promote.
Intra-Aortic Balloon Pump Reduces in-Hospital Mortality in Patients with Fulminant Myocarditis
Authors: Zhou Ning , Shu Hongyang , Hang Weijian , Li Chenze , Wu Dongyang , Wang Xiaoyan , Jiang Jiangang , Wang Dao Wen 
Published: June 2021

Abstract
A life support-based comprehensive treatment regimen, in which an intra-aortic balloon pump (IABP) unloads the left ventricle, has reduced the mortality of patients with fulminant myocarditis (FM). This study evaluated the efficacy of IABP in the treatment of patients with FM. A total of 100 patients diagnosed with FM were divided into two groups depending on the application of IABPs. 57 (57%) received IABPs within 30 min after admission (IABP group), whereas 43 (43%) did not (non-IABP group). In IABP group, 24.6% (14/57) died, compared to 34.9% (15/43) of those without IABPs (P < 0.01). The mean blood pressure (MBP), averaged heart rate (AHR), and left ventricular ejection fraction (LVEF) were similar between the two groups on admission. However, compared to the non-IABP group, MBP and LVEF were increased and AHR was significantly in IABP group. IABPs reduced the in-hospital mortality risk and improved the cardiac dysfunction in patients with FM.
The Impact of Schizotypy on Quality of Life Among Adults with Autism Spectrum Disorder
Authors: Klang Albin , Westerberg Britta , Humble Mats B. , Bejerot Susanne 
Published: June 2021

Abstract
Background: Autism spectrum disorder (ASD) and schizotypal personality disorder can be difficult to distinguish. Deficits in social relationships and social interaction, present in both conditions, are known to impair quality of life. The aim of the present study was to investigate if schizotypal symptoms affect quality of life among adults diagnosed with autism spectrum disorder and to study the association between schizotypy and autistic traits among them. Methods: Participants diagnosed with autism spectrum disorder (n=110) completed questionnaires exploring schizotypy (Schizotypal Personality Questionnaire – Brief Revised (SPQ-BR)), autistic traits (The Ritvo Autism, Asperger Diagnostic Scale-Revised Screen 14 items), anxiety and depression (The Hospital Anxiety and Depression scale) and quality of life (Brunnsviken Brief Quality of Life Scale and the European quality of life index version 5D). Results: Schizotypy was found to be associated with anxiety, depressive and autistic symptoms, and poor quality of life. Although schizotypy was a predictor for impaired quality of life, this relationship was mediated by symptoms of anxiety and depression, plausibly inherent to autism. Autistic traits were positively associated with all higher order constructs of the SPQ-BR, i.e. positive and negative schizotypy, disorganization and social anxiety, as well as with poor quality of life. Conclusions: There is considerable overlap between schizotypy and autism that needs to be considered in research. Prominent schizotypal traits in people with ASD may constitute an endophenotype coinciding with a particularly poor quality of life.
Quantitative Evaluation of the Supercontinuum Laser Eye Dazzling Effect: in vivo Experimental Research
Authors: Fan Yingwei , Ma Qiong , Liang Jie , Luo Zhenkun , Kang Hongxiiang 
Published: June 2021

Abstract
Background: Laser eye dazzling affects the visual performance through the instant high-intensity light stimulation. The temporary loss or deterioration of the visual function may occur when radiated by lasers. To quantitatively evaluate the dazzling effect of each spectrum band of supercontinuum laser, we conducted an experimental research for exploring the safety and dazzling of animals’ eyes. Methods: Under the condition of dark adaption, the laser with different power densities and spectral bands was output, and the rabbit eyes were radiated by normal incident mode for 0.25 s. The fundus of the rabbit eyes was examined through the inspection mirror, and the upper limit of safe power density was explored. Rabbit eyes were radiated at the upper limit of safe power density, and the microscopic damage model was established for pathomorphological analysis. The eyes were radiated with blinding light for 0.1 s. The visual electrophysiological signals were collected dynamically and the recovery time of ERG-b amplitude was recorded and analyzed after laser radiation. Results: Under dark adaptation, the upper limit of safe power density was 247.00 mW/cm2 in the VS, 194.00 mW/cm2 in the VIS, 1184.00 mW/cm2 in the IS, and 1052.00 mW/cm2 in the FS. The above power densities of laser radiation in rabbit eyes could cause pathological changes of retinal structure, such as local bulge, uneven thickness and disorder of inner and outer nuclear layers, local inflammatory exudation and so on. When the power density was 8.00 mW/cm2, the recovery time of ERG-b wave in rabbit eye was 4.11 ± 0.67 s. When the power density was 12.00 mW/cm2, the recovery time of ERG-b wave in rabbit eye was 4.16 ± 0.55 s. The recovery time of ERG-b wave was 4.50 ± 0.94 s at the power density of 4.60 mW/cm2 in the full spectrum-1, 3.81 ± 0.11 s at the power density of 5.00 mW/cm2 in the full spectrum-2, and 628.00 mW/cm2 in the infrared spectrum. The recovery time of ERG-b wave was only 0.84 ± 0.09 s. Conclusion: The VS, FS, FS-1 and FS-2 of the supercontinuum laser had a good dazzling effect on rabbit eyes, and the dazzling effect was enhanced with the increase of radiation power density, but the infrared spectrum had a little dazzling effect.
Silicosis-associated Severe Pneumonia Treated by Veno-veno-venous Extracorporeal Membrane Oxygenation: a Case Report
Authors: Xiong Ting , Su Xiao Fei , Liu Zuo Liang , Zhao Shang Ping 
Published: June 2021

Abstract
Background: Extracorporeal membrane oxygenation (ECMO) is an extracorporeal life support system (ECLS) for patients with severe cardiopulmonary failure, there are two basic patterns of veno-arterial (V-A) and veno-venous (V-V). Case presentation: This paper mainly introduced a death case of modified ECMO Patterns which is veno-veno-venous ECMO in the treatment of silicosis with severe pneumonia and analyzed the cause of death after treatment with VV-V ECMO. Conclusions: Although VV-V ECMO is recommended for patients with extremely poor oxygenation conditions, it still be difficult to improve the prognosis of patients with severe lung structural damage, and still has a long way to go.
Remarkably Enhanced Dielectric Stability and Energy Storage Properties in BNT-BST Relaxor Ceramics by A-Site Defect Engineering for Pulsed Power Applications
Authors: Li Zhipeng , Li Dongxu , Shen Zong-Yang , Zeng Xiaojun , Song Fusheng , Luo Wenqin , Wang Xingcai , Wang Zhumei , Li Yueming 
Published: June 2021

Abstract
Lead-free bulk ceramics for advanced pulsed power capacitors show relatively low recoverable energy storage density (Wrec) especially at low electric field condition. To address this challenge, we proposed an A-site defect engineering to optimize the electric polarization behavior by disrupting the orderly arrangement of A-site ions, in which Ba0.105Na0.325Sr0.245−1.5xð0.5xBi0.325+xTiO3 (BNS0.245−1.5xð0.5xB0.325+xT, x = 0, 0.02, 0.04, 0.06, 0.08) lead-free ceramics were selected as the representative. The BNS0.245−1.5xð0.5xB0.325+xT ceramics were prepared by using pressureless solid state sintering and achieved large Wrec (1.8 J/cm3) at a low electric field (@110 kV/cm) when x = 0.06. The value of 1.8 J/cm3 is super high as compared to all other Wrec in lead-free bulk ceramics under a relatively low electric field (< 160 kV/cm). Furthermore, a high dielectric constant of 2930 ± 15% in a wide temperature range of 40 ~ 350°C was also obtained in BNS0.245−1.5xð0.5xB0.325+xT (x = 0.06) ceramics. The excellent performances can be attributed to the A-site defect engineering, which can reduce Pr and improve the thermal evolution of polar nanoregions (PNRs). This work confirms that the BNS0.245−1.5xð0.5xB0.325+xT (x = 0.06) ceramics are desirable for advanced pulsed power capacitors, and will push the development of a series of BNT-based ceramics with high Wrec and high temperature stability.
Fuzzy Rate Analysis of Operators and its Applications in Linear Spaces
Authors: Zhang Yijin , Li Honggang , Jin Maoming , Lin Zongbing 
Published: June 2021

Abstract
In this paper, a new concept, the fuzzy rate of an operator in linear spaces is proposed for the very first time. Some properties and basic principles of it are studied. Fuzzy rate of an operator B which is specific in a plane is discussed. As its application, a new fixed point existence theorem is proved.
Reference genome assemblies reveal the origin and evolution of allohexaploid oat
Authors: Peng Yuanying , Yan Honghai , Guo Laichun , Deng Cao , Kang Lipeng , Wang Chunlong , Zhou Pingping , Yu Kaiquan , Dong Xiaolong , Zhao Jun , Peng Yun , Liu Xiaomeng , Deng Di , Xu Yinghong , Li Ying , Jiang Qiantao , Li Yan , Wei Liming , Wang Jirui , Ma Jian , Hao Ming , Li Wei , Kang Houyang , Zheng Youliang , Wei Yuming , Lu Fei , Ren Changzhong 
Published: June 2021

Abstract
Common oat (Avena sativa) is one of the most important cereal crops serving as a valuable source of forage and human food. While reference genomes of many important crops have been generated, such work in oat has lagged behind, primarily owing to its large, repeat-rich, polyploid genome. By using Oxford Nanopore ultralong sequencing and Hi-C technologies, we have generated the first reference-quality genome assembly of hulless common oat with a contig N50 of 93 Mb. We also assembled the genomes of diploid and tetraploid Avena ancestors, which enabled us to identify oat subgenome, large-scale structural rearrangements, and preferential gene loss in the C subgenome after hexaploidization. Phylogenomic analyses of cereal crops indicated that the oat lineage descended before wheat, offering oat as a unique window into the early evolution of polyploid plants. The origin and evolution of hexaploid oat is deduced from whole-genome sequencing, plastid genome and transcriptomes assemblies of numerous Avena species. The high-quality reference genomes of Avena species with different ploidies and the studies of their polyploidization history will facilitate the full use of crop gene resources and provide a reference for the molecular mechanisms underlying the polyploidization of higher plants, helping us to overcome food security challenges.