bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the angiographic-biologic phenotype in the IMAGINE study: quantitative UWFA and cytokine expression
Authors: Abraham Joseph R , Wykoff Charles C , Arepalli Sruthi , Lunasco Leina , Yu Hannah J , Martin Alison , Mugnaini Christopher , Hu Ming , Reese Jamie , Srivastava Sunil K , Brown David M , Ehlers Justis P 
Published: June 2021

BackgroundThis study investigates the association of intraocular cytokine expression and ultrawide-field fluorescein angiography (UWFA) quantitative imaging biomarkers and their association with angiographical feature response after antivascular endothelial growth factor (VEGF) therapy in diabetic macular oedema (DME).MethodsThe IMAGINE DME study is a post hoc imaging biomarker and intraocular cytokine assessment from the DAVE study, a prospective DME clinical trial that included aqueous humour sampling and UWFA imaging. Fifty-four cytokines associated with inflammation and angiogenesis were evaluated through multiplex arrays. UWFA parameters were assessed using an automated feature analysis platform to determine ischaemic and leakage indices and microaneurysm (MA) count. Eyes were classified into UWFA responder or non-responder groups based on longitudinal quantitative UWFA parameter improvement. Cytokine expression was correlated with UWFA metrics and evaluated in the context of therapeutic response.ResultsTwenty-one eyes were included with a mean age of 55±10 years. Increased panretinal leakage index correlated with VEGF (r=0.70, p=0.0005), angiopoietin-like 4 (r=0.77, p=4.6E-5) and interleukin (IL)-6 (r=0.64, p=0.002). Panretinal ischaemic index was associated with tissue inhibitor of metalloproteinases 1 (TIMP-1, r=0.49, p=0.03) and peripheral ischaemia correlated with VEGF (r=0.45, p=0.05). MA count correlated with increased monocyte chemotactic protein-4 (MCP-4, r=0.60, p=0.004) and platelet and endothelial cell adhesion molecule 1 (PECAM-1, r=0.58, p=0.005). Longitudinal MA reduction was associated with decreased baseline VEGF and urokinase receptor (uPAR) (p<0.05). High baseline VEGF and IL-6 were associated with dramatic reduction in macular leakage (p<0.05).ConclusionsBaseline and longitudinal quantitative UWFA imaging parameters correlated with multiple aqueous humour cytokine concentrations, including VEGF and IL-6. Further research is needed to assess the possible implications of using these findings for evaluating treatment response.
A finite box as a tool to distinguish free quarks from confinement at high temperatures
Authors: Glozman L. Ya. , Lang C. B. 
Published: June 2021

AbstractAbove the pseudocritical temperature$$T_c$$Tcof chiral symmetry restoration a chiral spin symmetry (a symmetry of the color charge and of electric confinement) emerges in QCD. This implies that QCD is in a confining mode and there are no free quarks. At the same time correlators of operators constrained by a conserved current behave as if quarks were free. This explains observed fluctuations of conserved charges and the absence of the rho-like structures seen via dileptons. An independent evidence that one is in a confining mode is very welcome. Here we suggest a new tool how to distinguish free quarks from a confining mode. If we put the system into a finite box, then if the quarks are free one necessarily obtains a remarkable diffractive pattern in the propagator of a conserved current. This pattern is clearly seen in a lattice calculation in a finite box and it vanishes in the infinite volume limit as well as in the continuum. In contrast, the full QCD calculations in a finite box show the absence of the diffractive pattern implying that the quarks are confined.
Baryogenesis, magnetogenesis and the strength of anomalous interactions
Authors: Giovannini Massimo 
Published: June 2021

AbstractThe production of the hypermagnetic gyrotropy is investigated under the assumption that the gauge coupling smoothly evolves during a quasi-de Sitter phase and then flattens out in the radiation epoch by always remaining perturbative. In the plane defined by the strength of the anomalous interactions and by the rate of evolution of the gauge coupling the actual weight of the pseudoscalar interactions turns out to be always rather modest if major deviations from the homogeneity are to be avoided during the inflationary phase. Even if the gauge power spectra are related by duality only in the absence of anomalous contributions, an approximate duality symmetry constrains the late-time form of the hypermagnetic power spectra. Since the hypermagnetic gyrotropy associated with the modes reentering prior to the phase transition must be released into fermions later on, the portions of the parameter space where the obtained baryon asymmetry is close to the observed value are the most relevant for the present ends. For the same range of parameters the magnetic power spectra associated with the modes reentering after symmetry breaking may even be of the order of a few hundredths of a nG over typical length scales comparable with the Mpc prior to the collapse of the protogalaxy.
Comment on: “Bi-interior ideals of semigroups”
Authors: Kehayopulu Niovi 
Published: June 2021

This is about the paper “Bi-interior ideals of semigroups” by M. Murali Krishna Rao in Discuss. Math. Gen. Algebra Appl. 38 (2018) 69–78. According to Theorem 3.11 (also Theorem 3.3(8)) of the paper, the intersection of a bi-interior ideal [Formula: see text] of a semigroup [Formula: see text] and a subsemigroup [Formula: see text] of [Formula: see text] is a bi-interior ideal of [Formula: see text]. Regarding to Theorem 3.6, every bi-interior ideal of a regular semigroup is an ideal of [Formula: see text]. We give an example that the above two results are not true for semigroups. According to the same paper, if [Formula: see text] is a regular semigroup then, for every bi-interior ideal [Formula: see text], every ideal [Formula: see text] and every left ideal [Formula: see text] of [Formula: see text], we have [Formula: see text]. The proof is wrong, we provide the corrected proof. In most of the results of the paper the assumption of unity is not necessary. Care should be taken about the proofs in the paper.
REPRESENTAÇÃO E PRÁTICAS DE UTILIZAÇÃO DE PRODUTOS AGROQUÍMICOS NA PEQUENA AGRICULTURA FAMILIAR DO VALE DO RIBEIRA, ESTADO DE SÃO PAULO, BRASIL
Authors: Antuniassi Maria Helena Rocha , Almeida Luis Carlos Ferreira de 
Published: June 2021

Trata-se de um estudo de sociologia realizado no âmbito de um programa de extensão rural desenvolvido no Vale do Ribeira – Estado de São Paulo-(2013/2014) por uma equipe do Centro de Estudos Rurais NAP/USP e da UNESP, Campus Experimental de Registro, tendo por objetivo disseminar junto aosprodutores rurais, sobretudo da agricultura familiar, conceitos e práticas relativas à saúde do trabalhador, principalmente a correta utilização do EPI e preservação do meio ambiente (solo e águas) para que suas atividadesse efetivem direcionadas para o desenvolvimento sustentado (socioeconômico e ambiental) de seu município e região. Tendo em vista os objetivos estabelecidos, o estudo foi realizado utilizando a observação participante, uma metodologia da pesquisa-ação que busca simultaneamente compreender e intervir; supõe familiaridade anterior com o objeto e tem, portanto, dois objetivos: produção de conhecimentos e mudança das práticas observadas, por meio de uma ação pedagógica, que tem por base não apenas o conhecimentoda experiência vivida dos agentes observados, mas as condições sociais de possibilidade dessa experiência (portanto, os efeitos e os limites). (BOURDIEU, 2003). Assim sendo, buscou-se apreender a representação dos agricultores sobre os produtos agroquímicos e sua utilização, tendo em vista a participaçãode suas associações e serviços de extensão rural nas suas práticas de utilização dos produtos.
Atherectomy and Drug-Coated Balloon Angioplasty for the Treatment of Long Infrapopliteal Lesions: A Randomized Controlled Trial
Authors: Rastan Aljoscha , Brodmann Marianne , Böhme Tanja , Macharzina Roland , Noory Elias , Beschorner Ulrich , Flügel Peter-Christian , Bürgelin Karlheinz , Neumann Franz-Josef , Zeller Thomas 
Published: June 2021

Background:
Prospective, randomized, multicenter trials show no beneficial impact of drug-coated balloon (DCB) therapy alone on the technical and clinical outcomes of infrapopliteal artery lesions in comparison to plain old balloon angioplasty. The aim of this study was to evaluate the performance of directional atherectomy (DA) plus DCB angioplasty versus DCB alone in treatment of long infrapopliteal artery lesions.

Methods:
We conducted a prospective, randomized, 2-center trial comparing the performance of DA+DCB and DCB alone in treatment of 80 patients with de novo infrapopliteal artery lesions. The primary study end point was the 6-month primary patency of the target lesion detected by angiography and duplex ultrasound. Secondary end points included clinically driven target vessel revascularization, amputation rates, and changes in Rutherford-Becker class at 1 year. A core laboratory provides independent analyses for all scheduled and unscheduled duplex ultrasound examinations and angiographies, and a research institute ensured independent data collection.

Results:

The mean target lesion length was 179.7±98.2 mm. Nine patients (11.3%) died during the follow-up period. At 6 months, primary patency was 49% (n=18) with DA+DCB versus 34% (n=12) with DCB alone (
P
=0.241), and clinically driven target vessel revascularization was 8% (n=3) versus 14% (n=5;
P
=0.475), respectively. At 1 year, the target lesion revascularization rates were 30% (n=10) versus 43% (n=12;
P
=0.308), the median in Rutherford-Becker class was 2 (0.25–5) versus 5 (0.25–5;
P
=0.329), and amputation rates were 22% (n=8) versus 32% (n=11;
P
=0.618) in the DA+DCB group and the DCB group, respectively.

Conclusions:
Treatment of long infrapopliteal artery lesions with DA+DCB versus DCB alone leads to comparable clinical and technical results at 6 months and 1 year.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01763476.
Ripple: An Investigation of the World's Most Advanced High-Yield Thermonuclear Weapon Design
Authors: Grams Jon 
Published: June 2021

Abstract
In 1962 the United States conducted its final atmospheric nuclear test series, Operation Dominic. The devices tested were designed and built by the Los Alamos Scientific Laboratory (LASL) and the Lawrence Radiation Laboratory (LRL). During the test series, LRL conducted four tests of a radically new design called the Ripple concept. Tests of the Ripple concept demonstrated performance characteristics that eclipse those of all nuclear weapons designed before or since. For numerous reasons discussed in the article, the Ripple concept was not pursued, but the technology it pioneered has been in continual development—for peaceful purposes—to this day. Until now, very little has been known about these tests and the concept behind them. This article, the result of a multiyear investigation, sheds light on the Ripple program for the first time, allowing for a largely complete account. Included are the origins of the concept and its designer, the technical characteristics, the significant role played by the geopolitical context, the test series in detail, and the cancellation and legacy of the program.
Analysis of EEG Data Using Complex Geometric Structurization
Authors: Kwessi E. A. , Edwards L. J. 
Published: June 2021

Abstract
Electroencephalogram (EEG) is a common tool used to understand brain activities. The data are typically obtained by placing electrodes at the surface of the scalp and recording the oscillations of currents passing through the electrodes. These oscillations can sometimes lead to various interpretations, depending on, for example, the subject's health condition, the experiment carried out, the sensitivity of the tools used, or human manipulations. The data obtained over time can be considered a time series. There is evidence in the literature that epilepsy EEG data may be chaotic. Either way, the Embedding Theory in dynamical systems suggests that time series from a complex system could be used to reconstruct its phase space under proper conditions. In this letter, we propose an analysis of epilepsy EEG time series data based on a novel approach dubbed complex geometric structurization. Complex geometric structurization stems from the construction of strange attractors using Embedding Theory from dynamical systems. The complex geometric structures are themselves obtained using a geometry tool, the α-shapes from shape analysis. Initial analyses show a proof of concept in that these complex structures capture the expected changes brain in lobes under consideration. Further, a deeper analysis suggests that these complex structures can be used as biomarkers for seizure changes.
NetPyNE Implementation and Scaling of the Potjans-Diesmann Cortical Microcircuit Model
Authors: Romaro Cecilia , Najman Fernando Araujo , Lytton William W. , Roque Antonio C. , Dura-Bernal Salvador 
Published: June 2021

Abstract
The Potjans-Diesmann cortical microcircuit model is a widely used model originally implemented in NEST. Here, we reimplemented the model using NetPyNE, a high-level Python interface to the NEURON simulator, and reproduced the findings of the original publication. We also implemented a method for scaling the network size that preserves first- and second-order statistics, building on existing work on network theory. Our new implementation enabled the use of more detailed neuron models with multicompartmental morphologies and multiple biophysically realistic ion channels. This opens the model to new research, including the study of dendritic processing, the influence of individual channel parameters, the relation to local field potentials, and other multiscale interactions. The scaling method we used provides flexibility to increase or decrease the network size as needed when running these CPU-intensive detailed simulations. Finally, NetPyNE facilitates modifying or extending the model using its declarative language; optimizing model parameters; running efficient, large-scale parallelized simulations; and analyzing the model through built-in methods, including local field potential calculation and information flow measures.
A Method for Efficient Implementation of a Radial-Based Noise Power Estimator for Weather Radars
Authors: Hurtado Martin 
Published: June 2021

AbstractIn a previous work, a weather radar algorithm with low computational cost has been developed to estimate the background noise power from the data collected at each radial. The algorithm consists of a sequence of steps designed to identify signal-free range volumes which are subsequently used to estimate the noise power. In this paper, we derive compact-closed form expressions to replace the numerical formulations used in the first two steps of the algorithm proposed in the original paper. The goal is to facilitate efficient implementation of the algorithm.
CNS demyelination associated with immune dysregulation and a novel CTLA-4 variant
Authors: Kaninia Stefania , Grammatikos Alexandros , Urankar Kathryn , Renowden Shelley A , Patel Nikunj K , Gompels Mark M , Rice Claire M 
Published: June 2021

Background: The cytotoxic T-lymphocyte antigen-4 (CTLA-4) pathway acts as a negative immune regulator of T-cell activation and promotes self-tolerance. Case: We report the first case of biopsy-proven central nervous system inflammatory demyelination in the context of primary immunodeficiency and a novel CTLA-4 variant. Conclusion: This case has significant implications for the development of novel treatments for autoimmune conditions including multiple sclerosis and further emphasises the need for caution with clinical use of CTLA-4 immune checkpoint inhibitors in those with a history of inflammatory demyelination.
Immobilization of the Wrist After Dorsal Wrist Ganglion Excision: A Systematic Review and Survey of Current Practice
Authors: Wong Chloe R. , Karpinski Marta , Hatchell Alexandra C. , McRae Mark H. , Murphy Jessica , McRae Matthew C. 
Published: June 2021

Background Postoperative care after dorsal wrist ganglion (DWG) excision is highly varied. The effect of immobilization of the wrist on patient outcomes has not yet been examined. Methods A systematic review of the literature was performed to determine whether wrist immobilization after DWG surgical excision is beneficial. A survey of hand surgeons in Canada was performed to sample existing practice variations in current immobilization protocols after DWG excision. Results A systematic review yielded 11 studies that rigidly immobilized the wrist (n = 5 open excision, n = 5 arthroscopic excision, n = 1 open or arthroscopic excision), 10 studies that used dressings to partially limit wrist motion (n = 5 open, n = 5 arthroscopic), 1 study (open) that did either of the above, and 2 studies (arthroscopic) that did not restrict wrist motion postoperatively. This ranged from 48 hours to 2 weeks in open DWG excision and 5 days to 3 weeks in arthroscopic DWG excision. The survey of Canadian hand surgeons had a similarly divided result of those who chose to immobilize the wrist fully (41%), partially (14%), or not at all (55%). Most surgeons surveyed who immobilized the wrist postoperatively did so for 1 to 2 weeks. Conclusion The systematic review and survey of Canadian hand surgeons reveal that hand surgeons are divided regarding the need to immobilize the wrist after DWG excision. In terms of functional outcome, there is no compelling data to suggest 1 strategy is superior. The time frame for immobilization when undertaken was short at 2 weeks or less. The systematic review is registered in the PROSPERO database (PROSPERO 2016:CRD42016050877).
Assessment of Columellar Widening with Columellar Strut Placement
Authors: Toman Julia , Benchetrit Liliya , Meyer Annika , Porterfield James Zachary , Lee Jonathan Y. , Lawson William , Lee Yan Ho 
Published: June 2021

Objective: The columellar strut is a frequently used technique to provide nasal tip support and projection that is commonly thought to increase columellar width. However, systematic review of the effect has not been reported in the literature. We report a quantitative evaluation of the effect of columellar strut placement on columellar width. Methods: A retrospective cohort study of changes in columellar width in base view photographs for patients who underwent primary rhinoplasty with columellar strut placement (n = 35) and the closely related septal extension graft (n = 9) and tongue-in-groove (n = 5) procedures at Mount Sinai Hospital between 2010 and 2017. The ratio of the columellar width to the intercanthal distance was used to standardize the results among patients. Comparisons were made at follow-up periods of <1 week, 2 to 4 weeks, 1 to 3 months, 3 to 6 months, 6 to 12 months, and >1 year of follow-up. Results: Forty-nine patients (41% female; average age of 43 ± 15 years) were reviewed. The columellar width showed a statistically significant increase for all follow-up date ranges with the exception of 1 week and 3 to 6 months post-operatively. At >1 year of post-operative follow-up, the mean increase in columellar width was 8.6% (95% CI, 2.6%-14.5%, P = .0098). No statistically significant differences were noted between open versus closed procedure for all followup visits after the 1 week followup, and no significant difference if a septocolumellar stitch was placed. Conclusions: A columellar strut was demonstrated to lead to an increase in columellar width. Though the effect was modest at a 8.6% increase, this is a potential cosmetic consideration for the surgeon employing its use to provide nasal tip support and projection.
2-kupl: mapping-free variant detection from DNA-seq data of matched samples
Authors: Wang Yunfeng , Xue Haoliang , Pourcel Christine , Du Yang , Gautheret Daniel 
Published: June 2021

Abstract
Background
The detection of genome variants, including point mutations, indels and structural variants, is a fundamental and challenging computational problem. We address here the problem of variant detection between two deep-sequencing (DNA-seq) samples, such as two human samples from an individual patient, or two samples from distinct bacterial strains. The preferred strategy in such a case is to align each sample to a common reference genome, collect all variants and compare these variants between samples. Such mapping-based protocols have several limitations. DNA sequences with large indels, aggregated mutations and structural variants are hard to map to the reference. Furthermore, DNA sequences cannot be mapped reliably to genomic low complexity regions and repeats.

Results
We introduce 2-kupl, a k-mer based, mapping-free protocol to detect variants between two DNA-seq samples. On simulated and actual data, 2-kupl achieves higher accuracy than other mapping-free protocols. Applying 2-kupl to prostate cancer whole exome sequencing data, we identify a number of candidate variants in hard-to-map regions and propose potential novel recurrent variants in this disease.

Conclusions
We developed a mapping-free protocol for variant calling between matched DNA-seq samples. Our protocol is suitable for variant detection in unmappable genome regions or in the absence of a reference genome.
A novel miRNA-based classification model of risks and stages for clear cell renal cell carcinoma patients
Authors: Dessie Eskezeia Y. , Tsai Jeffrey J. P. , Chang Jan-Gowth , Ng Ka-Lok 
Published: June 2021

Abstract
Background
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal carcinoma and patients at advanced stage showed poor survival rate. Despite microRNAs (miRNAs) are used as potential biomarkers in many cancers, miRNA biomarkers for predicting the tumor stage of ccRCC are still limitedly identified. Therefore, we proposed a new integrated machine learning (ML) strategy to identify a novel miRNA signature related to tumor stage and prognosis of ccRCC patients using miRNA expression profiles. A multivariate Cox regression model with three hybrid penalties including Least absolute shrinkage and selection operator (Lasso), Adaptive lasso and Elastic net algorithms was used to screen relevant prognostic related miRNAs. The best subset regression (BSR) model was used to identify optimal prognostic model. Five ML algorithms were used to develop stage classification models. The biological significance of the miRNA signature was analyzed by utilizing DIANA-mirPath.

Results
A four-miRNA signature associated with survival was identified and the expression of this signature was strongly correlated with high risk patients. The high risk patients had unfavorable overall survival compared with the low risk group (HR = 4.523, P-value = 2.86e−08). Univariate and multivariate analyses confirmed independent and translational value of this predictive model. A combined ML algorithm identified six miRNA signatures for cancer staging prediction. After using the data balancing algorithm SMOTE, the Support Vector Machine (SVM) algorithm achieved the best classification performance (accuracy = 0.923, sensitivity = 0.927, specificity = 0.919, MCC = 0.843) when compared with other classifiers. Furthermore, enrichment analysis indicated that the identified miRNA signature involved in cancer-associated pathways.

Conclusions
A novel miRNA classification model using the identified prognostic and tumor stage associated miRNA signature will be useful for risk and stage stratification for clinical practice, and the identified miRNA signature can provide promising insight to understand the progression mechanism of ccRCC.