bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diffusion Tensor Imaging Correlates of Resilience Following Adolescent Traumatic Brain Injury
Authors: Schmidt Adam T. , Lindsey Hannah M. , Dennis Emily , Wilde Elisabeth A. , Biekman Brian D. , Chu Zili D. , Hanten Gerri R. , Formon Dana L. , Spruiell Matthew S. , Hunter Jill V. , Levin Harvey S. 
Published: December 2021

Background:
Traumatic brain injury (TBI) is associated with considerable mortality and morbidity in adolescents, but positive outcomes are possible. Resilience is the concept that some individuals flourish despite significant adversity.

Objective:
To determine if there is a relationship between resilience-promoting factors that are known to promote resilience and white matter (WM) microstructure 1 year after complicated mild TBI or moderate or severe TBI that is sustained by adolescents.

Method:
We examined the relationship between performance on a self-report measure of resilience-promoting factors and WM integrity assessed by diffusion tensor imaging in a group of adolescents who had sustained either a TBI (n = 38) or an orthopedic injury (OI) (n = 23).

Results:
Immediately following injury, the individuals with TBI and the OI controls had comparable levels of resilience-promoting factors; however, at 1 year post injury, the TBI group endorsed fewer resilience-promoting factors and exhibited WM disruption compared with the OI controls. The individuals with TBI who had more resilience-promoting factors at 1 year post injury exhibited increased WM integrity, but the OI controls did not. Findings were particularly strong for the following structures: anterior corona radiata, anterior limb of the internal capsule, and genu of the corpus callosum—structures that are implicated in social cognition and are frequently disrupted after TBI. Relationships were notable for caregiver and community-level resilience-promoting factors.

Conclusion:
The current findings are some of the first to indicate neurobiological evidence of previously noted buffering effects of resilience-promoting factors in individuals with TBI.
A Randomized Trial of a Wearable UV dosimeter for Skin Cancer Prevention
Authors: Dumont Emmanuel LP , Kaplan Peter D , Do Catherine , Banerjee Shayak , Barrer Melissa , Ezzedine Khaled , Zippin Jonathan H , Varghese George I 
Published: December 2021

ABSTRACTBackgroundNon-melanoma skin cancer (NMSC) is the most prevalent cancer in the United States. Despite guidelines on ultraviolet (UV) avoidance, it remains difficult for people to assess their exposure, as UV is invisible and the onset of UV-induced symptoms is delayed.MethodsIn a prospective randomized trial, ninety-seven elderly patients with a history of actinic keratoses (AK) were enrolled and followed over six months. Fifty patients received UV counseling by a dermatologist and a wearable UV dosimeter that provided real-time and cumulative UV exposure. Forty-seven patients solely received UV counseling by a dermatologist.ResultsOver 75% of participants recorded UV exposure at least once a week during the summer. After 6 months of intervention, when comparing the device group to the control group, we observed a non-significant 20% lower ratio of incidence rates of AKs (95% CI = [-41%, 55%], p-value = 0.44) and a significant 95% lower ratio of incidence rates of NMSCs (95% CI = [33%, 99.6%], p-value = 0.024). Self-reported surveys demonstrated that the control group’s score in self-perceived ability to participate in social activities significantly increased by 1.2 (p-value = 0.04), while in the device group, this score non-significantly decreased by 0.9 (p-value = 0.1). Finally, we did not observe changes, or between-group differences, in self-reported anxiety and depression surveys.ConclusionThis pilot clinical trial has a short duration and a small sample size. However, device adherence and quality of life questionnaires suggest a smartphone-connected wearable UV dosimeter is well accepted by an elderly population. This trial also indicates that a wearable UV dosimeter may be an effective behavioral change tool to reduce NMSC incidence in an elderly population with a prior history of AKs.Trial RegistrationThe trial was registered onclinicaltrials.govunder the identificationNCT03315286.
Transcriptional adaptation of sensory neurons to GPCR identity and activity
Authors: Horgue Luis Flores , Assens Alexis , Fodoulian Leon , Archinto Leonardo Marconi , Tuberosa Joël , Haider Alexander , Boillat Madlaina , Carleton Alan , Rodriguez Ivan 
Published: December 2021

AbstractSensory adaptation is critical to extract information from a changing world. Taking advantage of the extensive parallel coding lines present in the olfactory system, we explored the potential variations of neuronal identities before and after olfactory experience. We found that at rest, the transcriptomic profiles of olfactory sensory neuron populations are already highly divergent, specific to the olfactory receptor they express, and are surprisingly associated with the sequence of these latter. These divergent profiles further evolve in response to the environment, as odorant exposure leads to massive reprogramming via the modulation of transcription. Adenylyl cyclase 3, but not other main elements of the olfactory transduction cascade, plays a critical role in this activity-induced transcriptional adaptation. These findings highlight a broad range of sensory neuron identities that are present at rest and that adapt to the experience of the individual, thus providing a novel layer of complexity to sensory coding.
SARS-CoV-2 Virus like Particles produced by a single recombinant baculovirus generate potent neutralizing antibody that protects against variant challenge
Authors: Sullivan Edward , Sung Po-Yu , Wu Weining , Berry Neil , Kempster Sarah , Ferguson Deborah , Almond Neil , Jones Ian M. , Roy Polly 
Published: December 2021

ABSTRACTThe Covid-19 pandemic caused by SARS-CoV-2 infection has highlighted the need for the rapid generation of efficient vaccines for emerging disease. Virus-like particles, VLPs, are an established vaccine technology that produces virus-like mimics, based on expression of the structural proteins of a target virus that can stimulate strong neutralizing antibody responses. SARS-CoV-2 is a coronavirus where the basis of VLP formation has been shown to be the co-expression of the spike, membrane and envelope structural proteins. Here we describe the generation of SARS-CoV-2 VLPs by the co-expression of the salient structural proteins in insect cells using the established baculovirus expression system. VLPs were heterologous ∼100nm diameter enveloped particles with a distinct fringe that reacted strongly with SARS-CoV-2 convalescent sera. In a Syrian hamster challenge model, a non-adjuvanted VLPs induced neutralizing antibodies to the VLP-associated Wuhan S protein, reduced virus shedding following a virulent challenge with SARS-CoV-2 (B.1.1.7 variant) and protected against disease associated weight loss. Immunized animals showed reduced lung pathology and lower challenge virus replication than the non-immunized controls. Our data, using an established and scalable technology, suggest SARS-CoV-2 VLPs offer an efficient vaccine that mitigates against virus load and prevents severe disease.
Development of PRPK Directed Phthalimides
Authors: Seo Hyuk-Soo , Mizutani Takashi , Hideshima Teru , Vangos Nicholas E. , Zhang Tinghu , Anderson Kenneth C. , Gray Nathanael S. , Dhe-Paganon Sirano 
Published: December 2021

AbstractImmunomodulatory drugs (IMiDs) thalidomide, lenalidomide, and pomalidomide (Pom) bind to cereblon (CRBN) and trigger proteasomal degradation of neo-substrates IKZF1/3 leading to multiple myeloma (MM) cell apoptosis. Pomalidomide (Pom) also binds albeit weakly to p53-related protein kinase (PRPK, aka TP53RK), an understudied kinase reported to be associated with poor prognosis in MM patients. Here, we developed a series of IMiDs based on Pom and conducted a structure-activity relationship (SAR) study to identify a potent and selective PRPK binder. Structural analysis showed that IMiDs bind PRPK in a fundamentally different way from CRBN, and suggested specific derivatization to improve affinity. We employed a structure-guided strategy to develop compound TXM-02-118, which exhibited nanomolar affinityfor PRPK in binding assays, and showed high selectivity for PRPK over CRBN. Overall, the work represents an initial effort to develop tool compounds for studying PRPK. Moreover, it illustrates how a single class of molecules can use different recognition elements to bind diverse targets using fundamentally different binding poses. This has broad implications for chemical probe and lead compound selectivity profiling, and argues for more wide-spread use of global proteomics or similar methodologies.
Communication determines population-level fitness under cation stress by modulating the ratio of motile to sessile B. subtilis cells
Authors: Steinfeld Benedikt K. , Cui Qinna , Schmidt Tamara , Bischofs Ilka B. 
Published: December 2021

AbstractBacterial populations frequently encounter potentially lethal environmental stress factors. Growing Bacillus subtilis populations are comprised of a mixture of “motile” and “sessile” cells but how this affects population-level fitness under stress is poorly understood. Here, we show that, unlike sessile cells, motile cells are readily killed by monovalent cations under conditions of nutrient deprivation – owing to elevated expression of the lytABC operon, which codes for a cell-wall lytic complex. Forced induction of the operon in sessile cells also causes lysis. We demonstrate that population composition is regulated by the quorum sensing regulator ComA, which can favor either the motile or the sessile state. Specifically social interactions by ComX-pheromone signaling enhance population-level fitness under stress. Our study highlights the importance of characterizing population composition and cellular properties for studies of bacterial physiology and functional genomics. Our findings open new perspectives for understanding the functions of autolysins and collective behaviors that are coordinated by chemical and electrical signals, with implications for multicellular development and biotechnology.
Skeletal muscle releases extracellular vesicles with distinct protein and miRNA signatures that accumulate and function within the muscle microenvironment
Authors: Watanabe Sho , Sudo Yuri , Kimura Satoshi , Tomita Kenji , Noguchi Makoto , Sakurai Hidetoshi , Shimizu Makoto , Takahashi Yu , Sato Ryuichiro , Yamauchi Yoshio 
Published: December 2021

AbstractExtracellular vesicles (EVs) contain various regulatory molecules and mediate intercellular communications. Although EVs are secreted from various cell types, including skeletal muscle cells, and present in the blood, their identity is poorly characterized in vivo, limiting the identification of their origin in the blood. Since the skeletal muscle is the largest organ in the body, it could substantially contribute to circulating EVs as their source. However, due to the lack of defined markers that distinguish SkM-EVs from others, whether the skeletal muscle releases EVs in vivo and how much the skeletal muscle-derived EVs (SkM-EVs) account for plasma EVs remain poorly understood. In this work, we perform quantitative proteomic analyses on EVs released from C2C12 cells and human iPS cell-derived myocytes and identify potential marker proteins that mark SkM-EVs. These markers we identified apply to in vivo tracking of SkM-EVs. The results show that skeletal muscle makes only a subtle contribution to plasma EVs as their source in both control and exercise conditions in mice. On the other hand, we demonstrate that SkM-EVs are concentrated in the skeletal muscle interstitium. Furthermore, we show that interstitium EVs are highly enriched with the muscle-specific miRNAs and repress the expression of the paired box transcription factor Pax7, a master regulator for myogenesis. Taken together, our findings reveal that the skeletal muscle releases exosome-like small EVs with distinct protein and miRNA profiles in vivo and that SkM-EVs mainly play a role within the muscle microenvironment where they accumulate.
Topological conditions for propagation of spatially-distributed neural activity
Authors: Tudoras Àlex , Reyes Alex D. 
Published: December 2021

AbstractAn important task of the nervous system is to transmit information faithfully and reliably across brain regions, a process that involves the coordinated activity of a relatively large population of neurons. In topographically organized networks, where the entering and exiting axons of neurons terminate in confined areas, successful propagation depends on the spatial patterns of activity: the firing neurons in a presynaptic or source layer must be located sufficiently close to each other to ensure that cells in the postsynaptic or target layer receive the requisite number of convergent inputs to fire. Here, we use principles of topology to define the conditions for transmitting information across layers. We show that simplicial complexes formed by source neurons can be used to: 1) determine whether target neurons receive suprathreshold inputs; 2) identify neurons within the active population that contribute to firing; and 3) discriminate between single and multiple active clusters of neurons.
Developing Industry 4.0 accountants: implications for higher education institutions in Namibia
Authors: Akande Joseph Olorunfemi , Atiku Sulaiman Olusegun 
Published: December 2021

Purpose
This study aims to examine the accounting skills required in Industry 4.0 to assist higher education institutions in developing Industry 4.0 accountants in Namibia.

Design/methodology/approach
This study adopted a qualitative approach for data collection and analysis. The participants (accountants and finance consultants) were selected using a purposive sampling technique. A self-administered questionnaire (open-ended) was administered to 120 participants. Useful information was retrieved from 99 participants in the participating accounting firms in Namibia. The data was analyzed using non-numerical content analysis via Atlas.ti, version 9.0.

Findings
Findings revealed the need to teach soft, technical and digital skills by higher education institutions in Namibia to enhance accounting graduates’ employability in Industry 4.0. The practical implication for higher education in Namibia is to do more in curriculum retooling.

Originality/value
There is a shortage of literature on the competency framework for Industry 4.0 accountants, particularly in Namibia. The outcomes of this study contribute to the extant literature and assist higher education institutions with helpful information for accounting programs review and enhance graduates’ employability in Namibia.
Factors affecting maintenance cost of public buildings: case study of Tanzania Buildings Agency and National Housing Corporation
Authors: Zeni Kassim Slim , Kikwasi Geraldine John 
Published: December 2021

PurposeThe state of public buildings in Tanzania exhibits evidence of a lack of maintenance and repair. Despite efforts to raise the performance of public buildings, little emphasis is placed on maintenance works and related factors affecting maintenance costs of public buildings, which are often high. This study aims to examine factors affecting maintenance costs of public buildings.Design/methodology/approachThis was a case study involving two government building agencies – Tanzania Buildings Agency (TBA) and National Housing Corporation (NHC). A total of 387 tenants and 29 experts participated in the study. Data were collected using questionnaires and analyzed using Stata version 16 – descriptive statistics feature reporting absolute numbers and frequencies.FindingsBoth tenants and experts ranked building age, poor quality control, building material used, execution of work when it is urgent and inadequate financial resources as major factors affecting maintenance costs of public buildings. In the distinctive rating, tenants ranked resource management as a major factor, while experts ranked ignorance about the property of materials, misuse of buildings and faulty maintenance as major factors.Research limitations/implicationsThe study has some limitations such as geographical coverage which is limited to Dar es Salaam and Dodoma regions, hence missing information from other regions may have different experiences. Additionally, data were collected in a self-reported manner which could bring about information bias.Practical implicationsFindings of this study provide an insight on recent developments on the factors affecting maintenance cost of buildings using two cases of NHC and TBA which are single entities owning a substantial amount of housing units in Tanzania. Factors affecting the maintenance cost of public buildings identified in this study is a threshold for experts to devise strategies for minimizing maintenance costs.Originality/valueTo the best of the authors’ knowledge, this is the first study that assessed factors affecting maintenance cost in public buildings run by TBA and NHC from the tenant and expert perspectives.
Human governance a pathway to integrity in counteracting corruption
Authors: Ramli Nor Azmi , Abdul Mohsin Ainul Mohsein , Salleh Arfah , Mat Akhir Noor Shakirah 
Published: December 2021

Purpose
Corruption is a global phenomenon. The 2016 Organisation for Economic Co-operation and Development (OECD) Report and the 2019 Malaysia National Anti-Corruption Plan (NACP) Report stated that the government sector most prone to corruption is procurement. The purpose of this study is to explore what drives the government procurement practitioners to commit corruption or uphold integrity. The novelty of this research is it focusses on the human aspect based on a human model which comprises both the physical and non-physical dimensions. It incorporated four theories which are the virtue theory, transaction cost theory (TCT), human governance (HG) philosophy and Al-Ghazali theory of the soul to design the research framework.

Design/methodology/approach
This approach to counteract corruption is through the inner “Self” (spirituality) and is not limited or bound to processes, procedures, rules, regulations, systems and structures.

Findings
The findings obtained through the phenomenological method suggest that the Inciting Soul is the driver behind corruption. This happens when intellect (‘Aql) becomes submissive to appetition (Shahwa) and self-assertion (Ghadab) resulting in vice characters. In upholding integrity, Soul-at-Peace is the driver where intellect dominates appetition and self-assertion leading to virtue characters. The HG philosophy is what encapsulates the taxonomy of virtue character.

Research limitations/implications
This research concentrates only on understanding why corruption happens among those with authority. Nevertheless, this research did not delve into the inculcation of HG. Therefore, the authors would suggest for future research is to explore techniques to inculcate the ability of an individual to exercise all the necessary inner “Self” functions (to curb corruption) without having intervention from an external authority.

Practical implications
Corruption is a global phenomenon. The 2016 OECD Report and the 2019 Malaysia NACP Report found that procurement is the government sector most prone to corruption.

Originality/value
The novelty of this research is its focus on the human aspect based on the model of a human comprising both the physical and non-physical dimensions. The theoretical framework integrates the virtue theory, TCT, HG philosophy and Al-Ghazali theory of the Soul.
Reconfigurable manufacturing system: a systematic bibliometric analysis and future research agenda
Authors: Pansare Rajesh , Yadav Gunjan , Nagare Madhukar R. 
Published: December 2021

PurposeThe purpose of this paper is to conduct a systematic bibliometric analysis of reconfigurable manufacturing system (RMS) articles using VOSviewer to identify their research themes and future research trends and investigate their interconnectivity. This paper also aims to identify prominent authors, publishers, organizations, countries and their collaborations in the RMS domain.Design/methodology/approachIn this study, the Scopus database is used to retrieve 454 RMS articles published between 1988 and 2020. These articles are then investigated using VOSviewer to determine their interconnectedness, clusters and citations, as well as to generate a map based on text data. The network visualization diagrams and clusters obtained for documents, authors, sources, organizations and countries are explored to determine the current state and future trends in RMS research.FindingsA bibliometric analysis of selected articles is performed, and current research hotspots in this domain are identified. This work also investigates the current status and future research trends in this domain. The work presented also identifies top researchers, journals, countries and documents in RMS.Practical implicationsThis paper can provide academics, researchers and practitioners with additional research insights. At the same time, the research trends identified here can help to direct research and benefit researchers.Originality/valueThe study is the first attempt to review selected documents in the RMS domain using bibliometric analysis tools, and it presents a method for collecting articles, organizing them and analyzing the data.
Immunosenescence in the wild? A longitudinal study in a long‐lived seabird
Authors: Bichet Coraline , Moiron Maria , Matson Kevin D. , Vedder Oscar , Bouwhuis Sandra 
Published: December 2021

Abstract

Longitudinal studies of various vertebrate populations have demonstrated senescent declines in reproductive performance and survival probability to be almost ubiquitous. Longitudinal studies of potential underlying proximate mechanisms, however, are still scarce.

Due to its critical function in the maintenance of health and viability, the immune system is among the potential (mediators of) proximate mechanisms that could underlie senescence.

Here, we studied three innate immune parameters—haemagglutination titre, haemolysis titre and haptoglobin concentration—in a population of common terns (Sterna hirundo) known to undergo actuarial senescence. We repeatedly sampled birds of known sex and age across 11 years and used random regression models to (a) quantify how immune parameters vary among individuals and (b) describe within‐individual age‐specific changes in, and potential trade‐offs between, immune parameters.

Our models revealed no differences between males and females in haemagglutination titre and haptoglobin concentration, and very low among‐individual variation in these parameters in general. Within individuals, haemagglutination titre increased with age, while haptoglobin concentration did not change. We found no indication for selective (dis)appearance in relation to haemagglutination titre or haptoglobin concentration, nor for the existence of a trade‐off between them. Haemolysis was absent in the majority (76%) of samples.

Common terns do not exhibit clear senescence in haemagglutination titre and haptoglobin concentration and show very little among‐individual variation in these parameters in general. This may be explained by canalisation of the immune parameters or by the colonial breeding behaviour of our study species, but more longitudinal studies are needed to facilitate investigation of links between species’ characteristics and immunosenescence in wild animals.
A note on inequality measures for mixtures of double Pareto–lognormal distributions
Authors: Griffiths William , Chotikapanich Duangkamon , Hajargasht Gholamreza 
Published: December 2021

AbstractFormulas are derived for the Gini, Theil and Pietra coefficients for a population‐weighted mixture of double Pareto–lognormal (dPLN) distributions; they are applied to South America for 2 years. Results are also provided for the special case Pareto–lognormal and lognormal distributions. The formulas are useful for measuring regional or global inequality in large‐scale projects that utilise dPLN distributions or their special cases.