bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can we distinguish astrophysical from primordial black holes via the stochastic gravitational wave background?
Authors: Mukherjee Suvodip , Silk Joseph 
Published: July 2021

ABSTRACT
One of the crucial windows for distinguishing astrophysical black holes from primordial black holes is through the redshift evolution of their respective merger rates. The low redshift population of black holes of astrophysical origin is expected to follow the star formation rate. The corresponding peak in their merger rate peaks at a redshift smaller than that of the star formation rate peak (zp ≈ 2), depending on the time delay between the formation and mergers of black holes. Black holes of primordial origin are going to be present before the formation of the stars, and the merger rate of these sources at high redshift is going to be large. We propose a joint estimation of a hybrid merger rate from the stochastic gravitational wave background, which can use the cosmic history of merger rates to distinguish between the two populations of black holes. Using the latest bounds on the amplitude of the stochastic gravitational wave background amplitude from the third observation run of LIGO/Virgo, we obtain weak constraints at $68{{\ \rm per\ cent}}$ C.L. on the primordial black hole merger rate index $2.56_{-1.76}^{+1.64}$ and astrophysical black hole time delay $6.7_{-4.74}^{+4.22}$ Gyr. We should be able to distinguish between the different populations of black holes with the forthcoming O5 and A+ detector sensitivities.
Minimum perihelion distances and associated dwell times for near-Earth asteroids
Authors: Toliou Athanasia , Granvik Mikael , Tsirvoulis Georgios 
Published: July 2021

ABSTRACT
The observed near-Earth asteroid (NEA) population contains very few objects with small perihelion distances, say, $q \lesssim 0.2\, \mathrm{au}$. NEAs that currently have orbits with larger q might be hiding a past evolution during which they have approached closer to the Sun. We present a probabilistic assessment of the minimum q that an asteroid has reached during its orbital history. At the same time, we offer an estimate of the dwell time, that is, the time q has been in a specific range. We have re-analysed orbital integrations of test asteroids from the moment they enter the near-Earth region until they either collide with a major body or are thrown out from the inner Solar system. We considered a total disruption of asteroids at certain q as a function of absolute magnitude (H). We calculated the probability that an asteroid with given orbital elements and H has reached a q smaller than a given threshold value and its respective dwell time in that range. We have constructed a look-up table that can be used to study the past orbital and thermal evolution of asteroids as well as meteorite falls and their possible parent bodies. An application to 25 meteorite falls shows that carbonaceous chondrites typically have short dwell times at small q, whereas for ordinary chondrites it ranges from $10\, 000$ to $500\, 000$ yr. A dearth of meteorite falls with long dwell times and small minimum q supports a supercatastrophic disruption of asteroids at small q.
Modelling the linear polarization of GRB afterglows across the electromagnetic spectrum
Authors: Birenbaum Gal , Bromberg Omer 
Published: July 2021

ABSTRACT
Linear polarization measurements in the optical band show polarization degrees of a few per cent at late times. Recently, polarization at sub-per-cent level was also detected in radio by ALMA, opening the window for multiwavelength polarimetry and stressing the importance of properly modelling polarization in GRB afterglows across the EM spectrum. We introduce a numerical tool that can calculate the polarization from relativistically moving surfaces by discretizing them to small patches of uniform magnetic field, calculating the polarized emission from each cell assuming synchrotron radiation and summing it to obtain the total degree of polarization. We apply this tool to afterglow shocks with random magnetic fields confined to the shock plane, considering electron radiative cooling. We analyse the observed polarization curves in several wavelengths above the cooling frequency and below the minimal synchrotron frequency and point to the characteristic differences between them. We present a method to constrain the jet opening angle and the viewing angle within the context of our model. Applying it to GRB 021004, we obtain angles of ∼10○ and ∼8○ respectively and conclude that a non-negligible component of radial magnetic field is required to explain the ${\sim}1{{\ \rm per\ cent}}$ polarization level observed 3.5 days after the burst.
On the effect of pulsar evaporation on the cooling of white dwarfs
Authors: Tang Wenshi , Li Xiang-Dong 
Published: July 2021

ABSTRACT
Evolution of a large part of low-mass X-ray binaries (LMXBs) leads to the formation of rapidly rotating pulsars with a helium white dwarf (He WD) companion. Observations indicate that some He WDs in binary pulsar systems are ultracool (with the effective temperatures Teff ≲ 4000 K). It is hard to cool down a He WD to such low temperatures within the Hubble time because a thick hydrogen envelope was left behind around the He core after the mass transfer process. A possible mechanism that can accelerate the WD cooling is the evaporative wind mass-loss from the He WD driven by the high-energy radiation from the recycled pulsar. In this paper, we evolve a large number of LMXBs and investigate the influence of the pulsar’s high-energy radiation on the WD cooling with different input parameters, including the neutron star’s spin-down luminosity, the evaporation efficiency, and the metallicity of the companion star. By comparing our results with observations we note that, for relatively hot He WDs (with Teff &gt; 7000 K), standard WD cooling without evaporation considered is able to reproduce their temperatures, while evaporation is probably required for the He WDs with relatively low temperatures (Teff &lt; 5000 K).
A systematic reclassification of Type IIn supernovae
Authors: Ransome C L , Habergham-Mawson S M , Darnley M J , James P A , Filippenko A V , Schlegel E M 
Published: July 2021

ABSTRACT
Type IIn supernovae (SNe IIn) are a relatively infrequently observed subclass of SNe whose photometric and spectroscopic properties are varied. A common thread among SNe IIn is the complex multiple-component hydrogen Balmer lines. Owing to the heterogeneity of SNe IIn, online data bases contain some outdated, erroneous, or even contradictory classifications. SN IIn classification is further complicated by SN ‘impostors’ and contamination from underlying H ii regions. We have compiled a catalogue of systematically classified nearby (redshift z &lt; 0.02) SNe IIn using the Open Supernova Catalogue (OSC). We present spectral classifications for 115 objects previously classified as SNe IIn. Our classification is based on results obtained by fitting multiple Gaussians to the H α profiles. We compare classifications reported by the OSC and Transient Name Server (TNS) along with the best matched templates from snid . We find that 28 objects have been misclassified as SNe IIn. TNS and OSC can be unreliable; they disagree on the classifications of 51 of the objects and contain a number of erroneous classifications. Furthermore, OSC and TNS hold misclassifications for 34 and 12 (respectively) of the transients we classify as SNe IIn. In total, we classify 87 SNe IIn. We highlight the importance of ensuring that online data bases remain up to date when new or even contemporaneous data become available. Our work shows the great range of spectral properties and features that SNe IIn exhibit, which may be linked to multiple progenitor channels and environment diversity. We set out a classification scheme for SNe IIn based on the H α profile that is not greatly affected by the inhomogeneity of SNe IIn.
Future radio continuum cosmology clustering surveys
Authors: Asorey Jacobo , Parkinson David 
Published: July 2021

ABSTRACT
The use of continuum emission radio galaxies as cosmological tracers of the large-scale structure will soon move into a new phase. Upcoming surveys from the Australian Square Kilometre Array Pathfinder (ASKAP), MeerKAT, and the Square Kilometre Array project (SKA) will survey the entire available sky down to an $\sim 100\, \mu$Jy flux limit, increasing the number of detected extra-galactic radio sources by several orders of magnitude. External data and machine learning algorithms will also enable some low-resolution radial selection (photometric redshift binning) of the sample, increasing the cosmological utility of the sample observed. In this paper, we discuss the flux limit required to detect enough galaxies to decrease the shot-noise term in the error to be 10 per cent of the total. We show how future surveys of this type will be limited by available technology. The confusion generated by the intrinsic sizes of galaxies may have the consequence that surveys of this type eventually reach a hard flux limit of ∼100 nJy, as is predicted by the current modelling of AGN sizes by simulations such as the Tiered Radio Extragalactic Continuum Simulation (T-RECS). Finally, when considering the multitracer approach, where galaxies are split by type to measure some bias ratio, we find that there are not enough AGN present to achieve a reasonable level of shot noise for this kind of measurement.
Multifrequency study of the peculiar pulsars PSR B0919+06 and PSR B1859+07
Authors: Rajwade K M , Perera B B P , Stappers B W , Roy J , Karastergiou A , Rankin J M 
Published: July 2021

ABSTRACT
Since their discovery more than 50 years ago, broad-band radio studies of pulsars have generated a wealth of information about the underlying physics of radio emission. In order to gain some further insights into this elusive emission mechanism, we performed a multifrequency study of two very well-known pulsars, PSR B0919+06 and PSR B1859+07. These pulsars show peculiar radio emission properties whereby the emission shifts to an earlier rotation phase before returning to the nominal emission phase in a few tens of pulsar rotations (also known as ‘swooshes’). We confirm the previous claim that the emission during the swoosh is not necessarily absent at low frequencies and the single pulses during a swoosh show varied behaviour at 220 MHz. We also confirm that in PSR B0919+06, the pulses during the swoosh show a chromatic dependence of the maximum offset from the normal emission phase with the offset following a consistent relationship with observing frequency. We also observe that the flux density spectrum of the radio profile during the swoosh is inverted compared to the normal emission. For PSR B1859+07, we have discovered a new mode of emission in the pulsar that is potentially quasi-periodic with a different periodicity than is seen in its swooshes. We invoke an emission model previously proposed in the literature and show that this simple model can explain the macroscopic observed characteristics in both pulsars. We also argue that pulsars that exhibit similar variability on short time-scales may have the same underlying emission mechanism.
The effect of continuum elimination in identifying circumstellar dust around Mira
Authors: Shepard Lisa M , Speck Angela K 
Published: July 2021

ABSTRACTAsymptotic giant branch (AGB) stars are major contributors of cosmic dust to the universe. Typically, dust around AGB stars is investigated via radiative transfer (RT) modelling, or via simple deconstruction of observed spectra. However, methodologies applied vary. Using archival spectroscopic, photometric, and temporal data for the archetypal dusty star, Mira, we identify its circumstellar silicate dust grains. This is achieved by matching the positions and widths of observed spectral features with laboratory data. To do this comparison properly, it is necessary to account for the continuum emission. Here, we investigate various ways in which a continuum is eliminated from observational spectra and how it affects the interpretation of spectral features. We find that while the precise continuum shapes and temperatures do not have a critical impact on the positions and shapes of dust spectral features, it is important to eliminate continua in a specific way. It is important to understand what contributes to the spectrum in order to remove the continuum in a way that allows comparison with laboratory spectra of candidate dust species. Our methodologies are applicable to optically thin systems, like that of Mira. Higher optical depths will require RT modelling, which cannot include many different potential astrominerals because there is a lack of complex refractive indices. Finally, we found that the classic silicate feature exhibited by Mira is not consistent with a real amorphous silicate alone but may be best explained with a small alumina contribution to match the observed full width at half-maximum of the $\sim 10\, \mu$m feature.
Differential efficacies of Cas nucleases on microsatellites involved in human disorders and associated off-target mutations
Authors: Poggi Lucie , Emmenegger Lisa , Descorps-Declère Stéphane , Dumas Bruno , Richard Guy-Franck 
Published: July 2021

AbstractMicrosatellite expansions are the cause of &gt;20 neurological or developmental human disorders. Shortening expanded repeats using specific DNA endonucleases may be envisioned as a gene editing approach. Here, we measured the efficacy of several CRISPR–Cas nucleases to induce recombination within disease-related microsatellites, in Saccharomyces cerevisiae. Broad variations in nuclease performances were detected on all repeat tracts. Wild-type Streptococcus pyogenes Cas9 (SpCas9) was more efficient than Staphylococcus aureus Cas9 on all repeats tested, except (CAG)33. Cas12a (Cpf1) was the most efficient on GAA trinucleotide repeats, whereas GC-rich repeats were more efficiently cut by SpCas9. The main genetic factor underlying Cas efficacy was the propensity of the recognition part of the sgRNA to form a stable secondary structure, independently of its structural part. This suggests that such structures form in vivo and interfere with sgRNA metabolism. The yeast genome contains 221 natural CAG/CTG and GAA/CTT trinucleotide repeats. Deep sequencing after nuclease induction identified three of them as carrying statistically significant low frequency mutations, corresponding to SpCas9 off-target double-strand breaks.
Tertiary lymphoid tissues: a regional hub for kidney inflammation
Authors: Sato Yuki , Tamura Masaru , Yanagita Motoko 
Published: July 2021

Abstract
Tertiary lymphoid tissues (TLTs) are inducible ectopic lymphoid tissues that develop at sites of chronic inflammation in nonlymphoid organs. As with lymph nodes, TLTs initiate adaptive immune responses and coordinate local tissue immunity. Although virtually ignored for decades, TLTs have recently received a great deal of attention for their ability to influence disease severity, prognosis and response to therapy in various diseases, including cancer, autoimmune disorders and infections. TLTs are also induced in kidneys of patients with chronic kidney diseases such as immunoglobulin A nephropathy and lupus nephritis. Nevertheless, TLTs in the kidney have not been extensively investigated and their mechanism of development, functions and clinical relevance remain unknown, mainly because of the absence of adequate murine kidney TLT models and limited availability of human kidney samples containing TLTs. We recently found that aged kidneys, but not young kidneys, exhibit multiple TLTs after injury. Interestingly, although they are a minor component of TLTs, resident fibroblasts in the kidneys diversify into several distinct phenotypes that play crucial roles in TLT formation. Furthermore, the potential of TLTs as a novel kidney injury/inflammation marker as well as a novel therapeutic target for kidney diseases is also suggested. In this review article we describe the current understanding of TLTs with a focus on age-dependent TLTs in the kidney and discuss their potential as a novel therapeutic target and kidney inflammation marker.
Acidosis, cognitive dysfunction and motor impairments in patients with kidney disease
Authors: Imenez Silva Pedro H , Unwin Robert , Hoorn Ewout J , Ortiz Alberto , Trepiccione Francesco , Nielsen Rikke , Pesic Vesna , Hafez Gaye , Fouque Denis , Massy Ziad A , De Zeeuw Chris I , Capasso Giovambattista , Wagner Carsten A ,   CONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative Target), Capasso Giovambattista , Andrade Alexandre , Bachmann Maie , Bumblyte Inga , Covic Adrian Constantin , Delgado Pilar , Endlich Nicole , Engvig Andreas , Fouque Denis , Franssen Casper , Frische Sebastian , Garneata Liliana , Gesualdo Loreto , Giannakou Konstantinos , Goumenos Dimitrios , Kartal Ayşe Tuğba , Mani Laila-Yasmin , Marti Hans-Peter , Mayer Christopher , Nielsen Rikke , Pešić Vesna , Rroji Merita , Sakkas Giorgos , Spasovski Goce , Stevens Kate I , Vazelov Evgueniy , Viggiano Davide , Zacharia Lefteris , Ferreira Ana Carina , Malyszko Jolanta , Hoorn Ewout , Figurek Andreja , Unwin Robert , Wagner Carsten , Wanner Christoph , Bruchfeld Annette , Pepin Marion , Wiecek Andrzej , Nitsch Dorothea , Fridolin Ivo , Hafez Gaye , Romeo Maria José Soler , Barbieri Michelangela , Batinić Bojan , Carrasco Laura , Carriazo Sol , Gansevoort Ron , Martino Gianvito , Raso Francesco Mattace , Nistor Ionut , Ortiz Alberto , Paolisso Giuseppe , Rastenytė Daiva , Stefan Gabriel , Tedeschi Gioacchino , Massy Ziad , Bikbov Boris , Endlich Karl Hans , Godefroy Olivier , Chillon Jean-Marc , Kossioni Anastassia , Kurganaite Justina , Perico Norberto , Remuzzi Giuseppe , Grodzicki Tomasz , Trepiccione Francesco , Zoccali Carmine , Arici Mustafa , Blankestijn Peter , Eckardt Kai-Uwe , Fliser Danilo , Jiménez Eugenio Gutiérrez , Konig Maximilian , Rychlik Ivan , Deleidi Michela , Reusz George 
Published: July 2021

ABSTRACT
Metabolic acidosis, defined as a plasma or serum bicarbonate concentration &lt;22 mmol/L, is a frequent consequence of chronic kidney disease (CKD) and occurs in ~10–30% of patients with advanced stages of CKD. Likewise, in patients with a kidney transplant, prevalence rates of metabolic acidosis range from 20% to 50%. CKD has recently been associated with cognitive dysfunction, including mild cognitive impairment with memory and attention deficits, reduced executive functions and morphological damage detectable with imaging. Also, impaired motor functions and loss of muscle strength are often found in patients with advanced CKD, which in part may be attributed to altered central nervous system (CNS) functions. While the exact mechanisms of how CKD may cause cognitive dysfunction and reduced motor functions are still debated, recent data point towards the possibility that acidosis is one modifiable contributor to cognitive dysfunction. This review summarizes recent evidence for an association between acidosis and cognitive dysfunction in patients with CKD and discusses potential mechanisms by which acidosis may impact CNS functions. The review also identifies important open questions to be answered to improve prevention and therapy of cognitive dysfunction in the setting of metabolic acidosis in patients with CKD.
Preclinical modeling in glioblastoma patient-derived xenograft (GBM PDX) xenografts to guide clinical development of lisavanbulin—a novel tumor checkpoint controller targeting microtubules
Authors: Burgenske Danielle M , Talele Surabhi , Pokorny Jenny L , Mladek Ann C , Bakken Katrina K , Carlson Brett L , Schroeder Mark A , He Lihong , Hu Zeng , Gampa Gautham , Kosel Matthew L , Decker Paul A , Kitange Gaspar J , Schmitt-Hoffmann Anne , Bachmann Felix , Vaubel Rachael A , Eckel-Passow Jeanette E , Giannini Caterina , McSheehy Paul , Lane Heidi A , Elmquist William F , Sarkaria Jann N 
Published: July 2021

Abstract

Background
Glioblastoma (GBM) is an incurable disease with few approved therapeutic interventions. Radiation therapy (RT) and temozolomide (TMZ) remain the standards of care. The efficacy and optimal deployment schedule of the orally bioavailable small-molecule tumor checkpoint controller lisavanbulin alone, and in combination with, standards of care were assessed using a panel of IDH-wildtype GBM patient-derived xenografts.

Methods
Mice bearing intracranial tumors received lisavanbulin +/−RT +/−TMZ and followed for survival. Lisavanbulin concentrations in plasma and brain were determined by liquid chromatography with tandem mass spectrometry, while flow cytometry was used for cell cycle analysis.

Results
Lisavanbulin monotherapy showed significant benefit (P &lt; .01) in 9 of 14 PDXs tested (median survival extension 9%-84%) and brain-to-plasma ratios of 1.3 and 1.6 at 2- and 6-hours postdose, respectively, validating previous data suggesting significant exposure in the brain. Prolonged lisavanbulin dosing from RT start until moribund was required for maximal benefit (GBM6: median survival lisavanbulin/RT 90 vs. RT alone 69 days, P = .0001; GBM150: lisavanbulin/RT 143 days vs. RT alone 73 days, P = .06). Similar observations were seen with RT/TMZ combinations (GBM39: RT/TMZ/lisavanbulin 502 days vs. RT/TMZ 249 days, P = .0001; GBM26: RT/TMZ/lisavanbulin 172 days vs. RT/TMZ 121 days, P = .04). Immunohistochemical analyses showed a significant increase in phospho-histone H3 with lisavanbulin treatment (P = .01).

Conclusions
Lisavanbulin demonstrated excellent brain penetration, significant extension of survival alone or in RT or RT/TMZ combinations, and was associated with mitotic arrest. These data provide a strong clinical rationale for testing lisavanbulin in combination with RT or RT/TMZ in GBM patients.
Exposure to Nicotine Vapor Produced by an Electronic Nicotine Delivery System Causes Short-Term Increases in Impulsive Choice in Adult Male Rats
Authors: Flores Rodolfo J , Alshbool Fatima Z , Giner Priscilla , O’Dell Laura E , Mendez Ian A 
Published: July 2021

Abstract

Introduction
Traditional cigarette use influences cost-benefit decision making by promoting impulsive choice. However, the impact of nicotine exposure via electronic nicotine delivery systems on impulsivity remains unclear. Hence, the present study examined the short- and long-term effects of nicotine vapor on impulsive choice.

Methods
Twenty-four adult male rats were trained in the delay discounting task to choose between small immediate food rewards and large delayed food rewards. After 24 days of training in the task rats were exposed to vapor containing either 0, 12, or 24 mg/mL of nicotine for 10 days. To validate inhalation of nicotine vapor serum cotinine levels were analyzed on exposure days 1, 5, and 10 using enzyme-linked immunosorbent assay. Following vapor exposure, rats were retrained in the discounting task until rats displayed stable responding and the effects of nicotine vapor on choice preference were assessed.

Results
Rats exposed to 12 and 24 mg/mL nicotine vapor displayed higher serum cotinine levels than control rats exposed to 0 mg/mL vapor. There were no differences in impulsive choice between any vapor exposure groups when tested 15 days after exposure, across 6 days of stable responding, suggesting that nicotine vapor does not have long lasting effects on impulsive choice. Interestingly, a subsequent nicotine vapor challenge revealed short-term increases in impulsive choice immediately following a single exposure to 24 mg/mL nicotine vapor, relative to choice preference immediately following exposure to 0 mg/mL vapor.

Conclusions
These results suggest that exposure to nicotine vapor causes immediate, short-term increases in impulsive choice.

Implications
E-cigarette use is increasing at an alarming rate, particularly among adolescents and young adults. This is concerning given the lack of research into the effects of nicotine vapor exposure on the brain and behavior. The present study describes a viable rodent model of human e-cigarette use and suggests that exposure to nicotine vapor produces short-term increases in impulsive choice.