bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obstetrician involvement in planned midwife-led births: a cohort study in an obstetric department of a University Hospital in Switzerland
Authors: Morr Ann-Katrin , Malah Nicole , Messer Andrea Manuela , Etter Annina , Mueller Martin , Raio Luigi , Surbek Daniel 
Published: October 2021

Abstract
Background
Healthy women with low risk singleton pregnancies are offered a midwife-led birth model at our department. Exclusion criteria for midwife-led births include a range of abnormalities in medical history and during the course of pregnancy. In case of complications before, during or after labor and birth, an obstetrician is involved. The purpose of this study was 1) to evaluate the frequency of and reasons for secondary obstetrician involvement in planned midwife-led births and 2) to assess the maternal and neonatal outcome.

Methods
We analyzed a cohort of planned midwife-led births during a 14 years period (2006-2019). Evaluation included a comparison between midwife-led births with or without secondary obstetrician involvement, regarding maternal characteristics, birth mode, and maternal and neonatal outcome. Statistical analysis was performed by unpaired t-tests and Chi-square tests.

Results
In total, there were 532 intended midwife-led births between 2006 and 2019 (2.6% of all births during this time-period at the department). Among these, 302 (57%) women had spontaneous vaginal births as midwife-led births. In the remaining 230 (43%) births, obstetricians were involved: 62% of women with obstetrician involvement had spontaneous vaginal births, 25% instrumental vaginal births and 13% caesarean sections. Overall, the caesarean section rate was 5.6% in the whole cohort of women with intended midwife-led births. Reasons for obstetrician involvement primarily included necessity for labor induction, abnormal fetal heart rate monitoring, thick meconium-stained amniotic fluid, prolonged first or second stage of labor, desire for epidural analgesia, obstetrical anal sphincter injuries, retention of placenta and postpartum hemorrhage. There was a significantly higher rate of primiparous women in the group with obstetrician involvement. Arterial umbilical cord pH < 7.10 occurred significantly more often in the group with obstetrician involvement, while 5′ Apgar score < 7 did not differ significantly. The overall transfer rate of newborns to neonatal intensive care unit was low (1.3%).

Conclusion
A midwife-led birth in our setting is a safe alternative to a primarily obstetrician-led birth, provided that selection criteria are being followed and prompt obstetrician involvement is available in case of abnormal course of labor and birth or postpartum complications.
Depth-dependent variability of biological nitrogen fixation and diazotrophic communities in mangrove sediments
Authors: Luo Zhiwen , Zhong Qiuping , Han Xingguo , Hu Ruiwen , Liu Xingyu , Xu Wenjun , Wu Yongjie , Huang Weiming , Zhou Zhengyuan , Zhuang Wei , Yan Qingyun , He Zhili , Wang Cheng 
Published: October 2021

Abstract
Background
Nitrogen-fixing prokaryotes (diazotrophs) contribute substantially to nitrogen input in mangrove sediments, and their structure and nitrogen fixation rate (NFR) are significantly controlled by environmental conditions. Despite the well-known studies on diazotrophs in surficial sediments, the diversity, structure, and ecological functions of diazotrophic communities along environmental gradients of mangrove sediment across different depths are largely unknown. Here, we investigated how biological nitrogen fixation varied with the depth of mangrove sediments from the perspectives of both NFR and diazotrophic communities.

Results
Through acetylene reduction assay, nifH gene amplicon and metagenomic sequencing, we found that the NFR increased but the diversity of diazotrophic communities decreased with the depth of mangrove sediments. The structure of diazotrophic communities at different depths was largely driven by salinity and exhibited a clear divergence at the partitioning depth of 50 cm. Among diazotrophic genera correlated with NFR, Agrobacterium and Azotobacter were specifically enriched at 50–100 cm sediments, while Anaeromyxobacter, Rubrivivax, Methylocystis, Dickeya, and Methylomonas were more abundant at 0–50 cm. Consistent with the higher NFR, metagenomic analysis demonstrated the elevated abundance of nitrogen fixation genes (nifH/D/K) in deep sediments, where nitrification genes (amoA/B/C) and denitrification genes (nirK and norB) became less abundant. Three metagenome-assembled genomes (MAGs) of diazotrophs from deep mangrove sediments indicated their facultatively anaerobic and mixotrophic lifestyles as they contained genes for low-oxygen-dependent metabolism, hydrogenotrophic respiration, carbon fixation, and pyruvate fermentation.

Conclusions
This study demonstrates the depth-dependent variability of biological nitrogen fixation in terms of NFR and diazotrophic communities, which to a certain extent relieves the degree of nitrogen limitation in deep mangrove sediments.
Valorization of spent coffee grounds as the specialty material for dullness and aging of skin treatments
Authors: Kanlayavattanakul Mayuree , Lourith Nattaya , Chaikul Puxvadee 
Published: October 2021

Abstract
Background
Coffee beans contain oil with health benefits from fatty acids. The unprocessed and processed coffee beans are mostly identical in coffee oil quality and are substantively supplied for certain industries. However, the cost-effective valorization of specialty ingredients from spent coffee grounds for cosmetics is sparely presented. Linoleic acid-rich spent coffee oil, as a specialty material for skin lightening and antiaging cosmetics, is objectively to be presented.

Results
Spent coffee oils were prepared by different methods. The most cost-effective material with a high extraction yield, linoleic acid content and unsaturated/saturated fatty acid (UFA/SFA) ratio (13.21  ±  0.25, 32.09% and 0.97) was modified. The modified oil was boosted in linoleic acid (77.20% or 140.57% improvement) and the UFA/SFA ratio (33.12). The physicochemical properties of the oil were applicable for cosmetics as per its safety profiles in B16F10 melanoma and normal human skin fibroblast cells. The oil significantly better inhibited cellular melanogenesis than kojic and linoleic acids (p  <  0.01), with prominent tyrosinase and TRP-2 inhibitions. The cellular antioxidant activity of the oil was comparable to those of ascorbic and linoleic acids. The collagen stimulating efficacy of the oil was significantly better than that of ascorbic but comparable to that of linoleic acid as indicated by the MMP-2 inhibitory activities (p  <  0.01 and p  <  0.001, respectively).

Conclusions
The oil is a specialty material for skin brightening and skin wrinkle reduction/skin elasticity improvement products. A successive circular bioeconomy of spent coffee ground waste in a more profitable cosmetic industry is indicated.

Graphic abstract
Tyrosinase@HKUST-1: a super stable biocatalyst efficient for catecholic product synthesis
Authors: Lü Xiao-Feng , Feng Chao-Yun , Li Shuangfei , Liu Guo-Hao , Yang Zhen 
Published: October 2021

AbstractAlthough metal–organic frameworks (MOFs) have been considered as promising matrices for enzyme immobilization, HKUST-1, constructed from copper acetate (CuAc2) and benzene 1,3,5-tricarboxylate (BTC), has rarely been explored for this application. In this study, mushroom tyrosinase (EC 1.14.18.1) was immobilized in the form of tyrosinase@HKUST-1 following a simple reaction procedure by mixing BTC with the enzyme prior to addition of CuAc2. The resultant biocatalyst was characterized in both structural features and catalytic properties. Upon incorporation into the HKUST-1 frameworks, the enzyme gained a prominent enhancement in stability against pH, temperature and storage: When incubated at 50 °C and pH 6.0, tyrosinase@HKUST-1 presented a half-life of 32.6 h, which is 77-fold and over tenfold higher than that of the free enzyme and its other immobilization forms, respectively; and the catalyst fully maintained its activity for at least 2 months when stored at 30 °C. The applicability of this new biocatalyst was demonstrated by employing it as catalyst for regioselectiveortho-hydroxylation reactions to produce catecholic products with huge pharmacological effects, i.e., hydroxytyrosol andl-DOPA, with excellent yields and productivities. This study has thus offered a facile immobilization method to prepare a novel biocatalyst with super stability, and tyrosinase@HKUST-1 so formed from crude mushroom extract provides an efficient catalyst which can be applied to the production of catecholic products with health benefits.Graphical Abstract
Clinical Validity of a Prognostic Gene Expression Cluster-Based Model in Human Papillomavirus–Positive Oropharyngeal Carcinoma
Authors: Cavalieri Stefano , Serafini Mara S. , Carenzo Andrea , Canevari Silvana , Brakenhoff Ruud H. , Leemans C. René , Nauta Irene H. , Hoebers Frank , van den Hout Mari F. C. M. , Scheckenbach Kathrin , Hoffmann Thomas K. , Ardighieri Laura , Poli Tito , Quattrone Pasquale , Locati Laura D. , Licitra Lisa , De Cecco Loris 
Published: October 2021

PURPOSE Under common therapeutic regimens, the prognosis of human papillomavirus (HPV)–positive squamous oropharyngeal carcinomas (OPCs) is more favorable than HPV-negative OPCs. However, the prognosis of some tumors is dismal, and validated prognostic factors are missing in clinical practice. The present work aimed to validate the prognostic significance of our published three-cluster model and to compare its prognostic value with those of the 8th edition of the tumor-node-metastasis staging system (TNM8) and published signatures and clustering models. METHODS Patients with HPV DNA-positive OPCs with locoregionally advanced nonmetastatic disease treated with curative intent (BD2Decide observational study, NCT02832102 ) were considered as validation cohort. Patients were treated in seven European centers, with expertise in the multidisciplinary management of patients with head and neck cancer. The median follow-up was 46.2 months (95% CI, 41.2 to 50), and data collection was concluded in September 2019. The primary end point of this study was overall survival (OS). Three-clustering models and seven prognostic signatures were compared with our three-cluster model. RESULTS The study population consisted of 235 patients. The three-cluster model confirmed its prognostic value. Two-year OS in each cluster was 100% in the low-risk cluster, 96.6% in the intermediate-risk cluster, and 86.3% in the high-risk cluster ( P = .00074). For the high-risk cluster, we observed an area under the curve = 0.832 for 2-year OS, significantly outperforming TNM 8th edition (area under the curve = 0.596), and functional and biological differences were identified for each cluster. CONCLUSION The rigorous clinical selection of the cases included in this study confirmed the robustness of our three-cluster model in HPV-positive OPCs. The prognostic value was found to be independent and superior compared with TNM8. The next step includes the translation of the three-cluster model in clinical practice. This could open the way to future exploration of already available therapies in HPV-positive OPCs tailoring de-escalation or intensification according to the three-cluster model.
ОСОБЕННОСТИ СОЦИАЛЬНО-ПСИХОЛОГИЧЕСКОЙ И ФИЗИОЛОГИЧЕСКОЙ АДАПТАЦИИ КУРСАНТОВ ВУЗА МВД К УСЛОВИЯМ СЛУЖЕБНОЙ ДЕЯТЕЛЬНОСТИ
Authors: . Deryagina Larissa E. , Bulatetskiy Sergey V. 
Published: October 2021

Неоднозначность процесса профессиональной адаптации вызывает постоянный интерес исследователей. Целью нашей работы было выявление особенностей физиологической и социально-психологической адаптации курсантов к условиям служебной деятельности.
Материалы и методы. В исследовании принимали участие курсанты факультета психологии Московского университета МВД РФ им.В.Я. Кикотя в количестве 30 человек (7 юношей и 23 девушки) в возрасте от 18 до 22 лет. Уровень социально-психологической адаптации определяли по методике диагностики Роджерса-Даймонд, вегетативную регуляцию ритма сердца оценивали по параметрам вариабельности ритма сердца (ВРС) по методике Р.М. Баевского согласно Евро-Американским рекомендациям. Исследование ВРС проводили дважды, до заступления в суточный наряд и после его окончания.
Результаты. Все испытуемые разделились на 3 группы по уровню адаптированности от низкого до высокого (НУ, СУ, ВУ). Умеренное преобладание симпатических влияний перед заступлением в наряд сменялось нарастанием вклада парасимпатической системы в регуляцию ритма сердца после наряда в группах НУ и СУ. В группе ВУ до наряда преобладала активация парасимпатического отдела нервной системы. После наряда наблюдался эутонический тип регуляции.
Выводы. 1. Уровень социально-психологической адаптации курсантов взаимосвязан с паттерном вегетативной регуляции ритма сердца в ситуации суточного наряда. 2. У лиц с высоким уровнем адаптивности сформирована относительно автономная система регуляции ритма сердца, которая в силу независимости ее элементов отличается большей пластичностью, что облегчает ее приспособление к изменяющимся условиям среды, включая, приспособление к условиям служебной деятельности.
МОНИТОРИНГ ВЛИЯНИЯ АНТРОПОГЕННЫХ ФАКТОРОВ НА ЛЕСНЫЕ БИОГЕОЦЕНОЗЫ ЮЖНОГО ПОБЕРЕЖЬЯ ОЗ. БАЙКАЛ
Authors: Mikhailova Tatiana A. , Shergina Olga V. , Kalugina Olga V. 
Published: October 2021

Цель. Исследовать современное состояние лесных биогеоценозов в рекреационных зонах южного побережья Байкала по комплексу параметров древостоев и почвенного покрова, выявить участки, где необходимы безотлагательные меры по снижению рекреационной нагрузки.
Материалы и методы. В рекреационных зонах, характеризующихся высокими туристическими потоками, были заложены пробные площади (ПП) для обследования состояния лесных биогеоценозов по отечественным и международным методикам. Определяли изменение морфоструктурных параметров деревьев сосны обыкновенной (вида-индикатора), в образцах хвои – содержание биогенных элементов, белкового азота, фотосинтетических пигментов, некоторых поллютантов. Для исследования состояния почвы на ПП закладывали разрезы до глубины подстилающей породы. Определяли морфологические и физико-химические параметры верхних почвенных горизонтов, уровень обменных катионов в почвенном поглощающем комплексе (ППК), содержание подвижных форм ряда тяжелых металлов.
Результаты. При исследовании основных компонентов лесных биогеоценозов показано, что пресс рекреации является основным фактором, инициирующим процесс деградации почвы и древостоев. Системный характер этого процесса обусловлен биогеохимическими изменениями, вызванными нарушением физико-химических характеристик почвы, что приводит к дисбалансу биогенных элементов в ППК и ухудшению питательного режима почвы, соответственно, проявляется дисбаланс элементов в ассимиляционных органах деревьев и, как следствие, угнетение их ростовых параметров.
Применение результатов. Полученные данные служат информационной базой для региональных природоохранных органов при разработке мер, направленных на оптимизацию рекреационной нагрузки.
Заключение. Необходим постоянный мониторинг состояния лесов, окружающих Байкал и имеющих большую значимость в формировании стока воды в озеро.
QSAR МОДЕЛИРОВАНИЕ АНТИБАКТЕРИАЛЬНОЙ АКТИВНОСТИ ПРОИЗВОДНЫХ 1,2,4-ТРИАЗОЛА
Authors: Osipov Alexander L. , Trushina Veronika P. 
Published: October 2021

Цель. Разработка эффективных QSAR моделей предсказания антибактериальной активности для производных 1,2,4-триазола.
Методы и материалы исследования. Материалом для научных исследований послужили экспериментальные данные антибактериальной активности производных 1,2,4-триазола. Исследования проводились с помощью методов: QSAR моделирования, программирования, регрессионного многомерного анализа с помощью молекулярных дескрипторов.
Результаты. В работе описываются и анализируются математические модели предсказания антибактериальной активности на основе физико-химических параметров химических веществ. Проведены вычислительные эксперименты, которые продемонстрировали эффективность предложенных моделей. Сравнительный анализ моделей позволил выявить модель с наилучшими статистическими характеристиками: МАЕ=0,11; МАРЕ=10,74; точность прогноза=89,26%; MSE=0,0186; RMSE=0,1363.
Заключение. Были разработаны QSAR модели для прогнозирования антибактериальной активности двадцати восьми производных 1,2,4-триазола. В качестве факторов в моделях использовались от одного до шести молекулярных дескрипторов, порождаемых автоматически из структурных формул. Выбраны наилучшие модели на основе вычисленных статистических характеристик.
Talaqqi Method: Children's Language Development in Tahfidzul Al-Qur'an Program During Covid-19 Pandemic
Authors: Azizah Annafi Nurul Ilmi , Marhumah Marhumah , Sufa Feri Faila 
Published: October 2021

This study aims to describe the implementation of the talaqqi method in the development of language and religious values in the Qur'an tahfidzul program for early childhood applied in BA Aisyiyah Mayang Gatak. This research uses descriptive methods with a qualitative approach. The subjects of the study were the principal, Teacher Tahfidz, and Children. Data collection in this study using observation methods, interviews, and documentation. This study shows that the implementation of talaqqi method on language development in receptive language achievement is that the child will have many and varied vocabulary, can straighten the child's tongue, read letters well, children can pronounce according to the makhraj letter. The implementation of talaqqi method on the development of children's religious values can instill culture to children, invite children to love Allah SWT, Children are introduced to the Qur'an and love the Qur'an, and print a generation of praiseworthy morals. Children can understand and understand the content of the Qur'an, and children have a religious character from an early age.
Robust voice querying with MUVE
Authors: Wei Ziyun , Trummer Immanuel , Anderson Connor 
Published: October 2021

Recently proposed voice query interfaces translate voice input into SQL queries. Unreliable speech recognition on top of the intrinsic challenges of text-to-SQL translation makes it hard to reliably interpret user input. We present MUVE (Multiplots for Voice quEries), a system for robust voice querying. MUVE reduces the impact of ambiguous voice queries by filling the screen with multiplots, capturing results of phonetically similar queries. It maps voice input to a probability distribution over query candidates, executes a selected subset of queries, and visualizes their results in a multiplot.
Our goal is to maximize probability to show the correct query result. Also, we want to optimize the visualization (e.g., by coloring a subset of likely results) in order to minimize expected time until users find the correct result. Via a user study, we validate a simple cost model estimating the latter overhead. The resulting optimization problem is NP-hard. We propose an exhaustive algorithm, based on integer programming, as well as a greedy heuristic. As shown in a corresponding user study, MUVE enables users to identify accurate results faster, compared to prior work.
Solons Fr. 12 G.-P.2(= 9 W.2): ein Textvorschlag
Authors: Solitario Michele 
Published: October 2021

AbstractThis paper proposes a new conjecture for Solon fr. 12 G.-P.2(= 9 W.2). In this, as in other poems, Solon shows a clear desire to present himself as an expert in the political milieu and to serve as a guide for the community of Athens. The politician’s penetrating gaze, his far-sighted νόος, is able to graspin nucethe development of political dynamics which, if they prevail, could mean the ruin of the city as a whole. Solon frames his νόος as an indispensable tool for the analysis of the city and its optimal and timely planning. To a secular conception of the νόος, which is the essential characteristic of the excellent politician, is added a traditional one that considers the νόος as a gift of Apollo. In this way, Solon appears as a politically engaged poet of the πόλις who mediates between the fighting factions and tries to work for the good of the community.
The Effect of Movement Control Order on Quality of Life among Staffs in Faculty of Sport Science and Recreation UiTM Shah Alam
Authors: Ismail Mohammad Alif , Nazeri Ahmad Fadhil , Zailan Nur Ain Iwani , Ilias Noor Fatihah 
Published: October 2021

Coronavirus known as COVID-19 is a respiratory illness that affects people worldwide. Malaysia was also affected by this virus; therefore, the government announced the Movement Control Order (MCO) to break the COVID-19 chain. MCO possibly affects quality of life of working people. Therefore, the purpose of this study is to compare the effect of MCO on quality of life between academic and administrative staff in Faculty of Sport Science and Recreation, UiTM Shah Alam. This study utilised causal â€“ comparative research design involved academic and administrative staff. The sample analysed were N=52 comprised of 30 academic and 22 administrative staff. This study used SF-36 questionnaire to measure quality of life. Data was collected via online. T-test was used to identify the differences between the two groups. Academic staff quality of score was (M=56.90 Â± 6.97) and administrative staff was (M=59.7 Â± 7.54) score. The findings reported that there is no significant difference in quality of life, p = 0.669 between academic and administrative staff during MCO. Quality of life for both academic and administrative staff was affected during MCO due to COVID-19 pandemic.
Agenda y particularización del discurso político chino: un análisis evolutivo en la guerra comercial con los Estados Unidos
Authors: Mosquera Mariano 
Published: October 2021

¿Qué tendencias pueden identificarse en un análisis evolutivo sobre la agenda china en la guerra comercial con los Estados Unidos? La investigación analiza los dos documentos oficiales en la materia del gobierno de la República Popular China (de septiembre de 2018 y de junio de 2019), desde un marco teórico centrado en la racionalidad política china y en los estudios de agenda, y con herramientas propias del análisis autómatico de textos. Se obtiene como conclusión que el discurso político chino sostiene —como eje central— la intención de expandir el debate comercial a otros significados económicos, mantiene la crítica al proteccionismo y defiende su posición sobre la propiedad intelectual en China. Sin embargo, en el año 2019 en el discurso político chino adquieren una mayor centralidad los valores y principios cooperativos típicos de la retórica política china. Esto se destaca por sobre la estategia china de deconstrucción del discurso occidental sobre el conflicto comercial, lo cual es predominante, con abundante particularización discursiva, en el año 2018.