bluuebunny/crossref_metadata_2025_split huggingface dataset:
Could CSR improve the financial performance of developing countries’ firms? Analyses of mediating effect of intangible resources
Authors: Hamdoun Mohamed , Achabou Mohamed Akli , Dekhili Sihem 
Published: October 2021

PurposeThis paper aims to examine the link between corporate social responsibility (CSR) and financial performance in the context of developing countries. More specifically, the mediating role of a firm’s competitive advantage and intangible resources, namely, human capital and reputation are studied.Design/methodology/approachThe study considered a sample of 100 Tunisian firms. The analysis makes use of the structural equation modelling method to explore the relationship between CSR and financial performance, by including mediator variables.FindingsThe results confirm that CSR has no significant direct effect on financial performance. In particular, they indicate that the social dimension of CSR has a negative impact on performance. However, CSR does have a positive impact on competitive advantage via the two intangible resources considered, human capital and company reputation.Research limitations/implicationsThe research fills a gap that occurred in the previous literature. In effect, previous studies focussed only on the direct link between CSR and financial performance. In addition, it enriches the limited literature on CSR strategies in the context of developing countries. However, further studies should explore the opposite relationship, i.e. the impact of financial performance on CSR strategy. In addition, the authors believe that amongst other potential research avenues, it would be interesting to study the moderating role of the activity sector.Practical implicationsFrom a practical point of view, this study suggests new applications with respect to the link between CSR and financial performance. To enhance their company’s financial performance, managers need to ensure that intangible resources are managed efficiently.Originality/valueThe paper contributes to the literature by examining how a firm’s intangible resources mediate between CSR and competitive advantage and how competitive advantage mediates between intangible resources and financial performance. Second originality is related to the study of the link between CSR and the financial performance of business organisations in the context of a developing country.
Understanding coaching efficacy in education through activity systems: privileging the nuances of provision
Authors: Lofthouse Rachel M. , Rose Anthea , Whiteside Ruth 
Published: October 2021

PurposeThe research demonstrates the role of activity systems based in Cultural Historical Activity Theory as a means of analysing characteristics and efficacy of specific provisions of coaching in education.Design/methodology/approachThree examples of coaching in education were selected, involving 51 schools in England. The three examples were re-analysed using activity systems. This drew on existing evaluation evidence, gathered through interviews, questionnaires, focus groups and recordings of coaching.FindingsIn each example, the object of the coaching was to address a specific challenge to secure the desired quality of education. Using activity systems it is possible to demonstrate that coaching has a range of functions (both intended and consequential). The individual examples illustrate the potential of coaching to support change in complex and diverse education settings.Research limitations/implicationsThe use of existing data from evaluations means that direct comparisons between examples are not made. While data were collected throughout the duration of each coaching programme no follow-up data was available.Practical implicationsThe analysis of the examples of coaching using activity systems provides evidence of the efficacy of specific coaching provision in achieving individually defined objectives related to sustaining and improving specific educational practices.Originality/valueThe research offers insights into how coaching in education might be better tuned to the specific needs of contexts and the challenges experienced by the individuals working in them. In addition, it demonstrates the value of activity systems as an analytical tool to make sense of coaching efficacy.
What differentiates angel investors in pre-seed versus seed-stage investments? Evidence from India
Authors: Annamalaisami A. Niroopa Rani 
Published: October 2021

Purpose
Angel investments are increasingly getting specialized. In recent years, start-ups are raising pre-seed funding before seed-stage funding. Investors in pre-seed and seed-stage companies commonly are angel investors. The purpose of this paper is to understand the differences between these two groups of angel investors.

Design/methodology/approach
Data for this study obtained from angel funding deals from the sources such as Venture Intelligence, VCCEdge, Keiretsu Forum, Dealcurry and The Chennai Angels. A total of 732 angel investments made by 405 investors during 2014–18 were used in the analysis. Non-parametric tests and regression estimations were used to identify the differences between angel investors investing in pre-seed and seed-stage ventures. An index was developed to measure the extent of syndication in angel investments and used as an independent variable in the regression.

Findings
There are significant differences between angel investors investing in pre-seed and seed-stage ventures. The results show that angels with more industry-specific experience make a higher proportion of investment in seed-stage ventures. Seed-stage ventures attract investors from Tier-1 cities, whereas the pre-seed stage has higher investors from smaller cities. Though the investment size is smaller, the extent of syndication is greater in pre-seed stage investments.

Originality/value
To differentiate the angel investments between pre-seed and seed-stage funding, this study uses data from Indian start-ups. Further, this study develops a composite syndication index to measure the extent of syndication in angel investments and assesses its impact on an angel investor’s choice of pre-seed stage investments.
A composite tourism index for the competitiveness of marginal areas: a pilot application in a Southern Italy province
Authors: Moretto Valentino , Elia Gianluca , Ghiani Gianpaolo 
Published: October 2021

PurposeDifferently from traditional approaches that rely on the analysis of single dimensions of the tourism phenomenon, this study aims to experiment a systemic approach based on structured and unstructured data sources to elaborate a composite index to measure the tourist competitiveness of marginal areas, with the final aim to design and plan proper socio-economic development strategies.Design/methodology/approachThe methodology adopted to carry out the study follows a four-step process and relies on indicators that are both relevant and accessible. The first step concerns the analysis of the literature about the existing approaches to calculate a tourism index. The second step concerns the definition of the indicators and the collection of data by using both structured and unstructured sources. The third step focuses on the population of the data set. Finally, the fourth step aims at calculating the tourism index through a composite-based methodology and using it for a pilot application in a Southern Italy province.FindingsThe study calculates a synthetic tourism index for each of the 97 municipalities of the Province of Lecce (a city located in the southeast of Italy). The proposed index combines administrative, institutional and open data sources to derive a single indicator for each municipality, thus supporting decision-makers in understanding the complex reality and competitiveness level of territories in the tourism industry.Originality/valueThe main elements of originality of the study are the breadth and typology of data sources considered to calculate the composite indicator of tourism competitiveness (both structured and unstructured); and the use of weighting and aggregation procedures in the methodological issues.
Locomotive syndrome is associated with insufficient nutrient intake in young and middle-aged adults: a cross-sectional survey
Authors: Ohtsuki Makoto , Nishimura Akinobu , Kato  Toshihiro , Wakasugi Yusuke , Nagao-Nishiwaki Rie , Komada Ai , Sudos Akihiro 
Published: October 2021

Purpose
This paper aims to investigate the relationship between locomotive syndrome (LS) and insufficient nutrient intake in young and middle-aged adults, independent of energy intake.

Design/methodology/approach
The authors conducted a cross-sectional survey of a non-random sample of 219 adults aged 18 to 64 (175 men and 44 women) working in two companies in Japan, between December 2018 and March 2019. LS Stage 0 was classified as No-LS while Stages 1 and 2 were classified as LS. Nutrient intake was assessed using a brief-type self-administered diet history questionnaire and adjusted to the required energy intake for each participant. The criteria for sufficient intake of 22 nutrients were based on the Dietary Reference Intake for Japanese. Logistic regression model was used to analyze the association between LS and insufficient nutrient intake.

Findings
In total, 234 employees participated in the LS examinations while 219 of them completed the questionnaire giving a response rate of 93.6%. LS Stages 1 or 2 were present in both men and women in all the age-stratified groups except for the women in their 60s. There was a significant association between LS status and insufficient intake of Vitamin K (odds ratio [95% confidence interval] 16.0 [range: 1.1–407]; p = 0.01) in women, but not in men.

Research limitations/implications
The result suggests that attention should be paid to adequate Vitamin K intake in young and middle-aged women with LS. Future studies should be conducted using a larger and more diverse sample.

Originality/value
To the best of the authors’ knowledge, the present paper is the first study to show an association between LS in young and middle-aged adults and nutrients that are independent of energy intake.
Metrics, metrics, metrics: the emergence of technological universities in Ireland
Authors: Stephens Simon , Gallagher Padraig 
Published: October 2021

Purpose
This paper aims to explore the experiences, attitudes and expectations of higher education managers in relation to the increased use of metrics. Specifically, the authors examine a system of metrics which was introduced as part of the process for establishing Technological Universities in Ireland.

Design/methodology/approach
A total of 12 managers were interviewed. The authors present data from the interviews in which the authors explore: the previous use of metrics; the impacts of the introduction of metrics; and the future use of metrics. A mix of narrative structuring and thematic analysis is used.

Findings
The introduction of metrics evokes a mixed reaction from the managers. The metrics allow performance in a range of activities to be measured, assessed and benchmarked. However, there are both direct and indirect impacts of the transition to a metric-based system, which the authors explore using six themes.

Originality/value
The authors apply the Academics Responding to Change model proposed by Trowler (1998) as the theoretical lens. This helps to capture the complex mix of direct and indirect effects that metrics can have on activities both at an individual and institutional level.
Commentary on “Including people with intellectual disabilities in the development of their own positive behaviour support plans”
Authors: Lee Steven , Stewart Kitty 
Published: October 2021

Purpose
The purpose of this paper is to broaden the discussion on some of the barriers and solutions for co-production in positive behaviour support (PBS) planning as identified in the paper “Including people with intellectual disabilities in the development of their own Positive Behaviour Support Plans”.

Design/methodology/approach
Drawing on the literature associated with co-production in PBS planning, this commentary will reflect on the wider systems and culture needed to enable successful implementation of this way of working.

Findings
Co-production in PBS planning is recommended as part of best practice guidelines. However, there is limited research in the area of co-production with regards to PBS and use of augmentative and alternative communication methods. Collaboration among speech and language therapy and PBS practitioners is an important factor for co-production to achieve the best outcomes for people with learning disabilities who display behaviours of concern. Along with identifying a range of communication tools/strategies needed for PBS assessment/planning, it also requires a whole systems approach and culture shift to ensure the necessary foundations are in place.

Originality/value
Co-production in PBS planning remains an under practiced way of working. This commentary builds on the barriers and solutions identified for co-production and provides further insight into what might be needed to achieve this in health and social care settings.
Indocyanine green fluorescence‐guided laparoscopic deroofing of a liver cyst: A case report
Authors: Tanioka Nobuhisa , Maeda Hiromichi , Shimizu Shigeto , Munekage Masaya , Uemura Sunao , Hanazaki Kazuhiro 
Published: October 2021

AbstractIn performing laparoscopic deroofing (LD) of liver cysts, indocyanine green (ICG) fluorescent imaging is particularly useful for delineating adequate margins for the procedure and for avoiding duct injuries. However, the optimal timing of ICG injection has not yet been clarified. Herein, we describe a patient who had a large liver cyst, in whom safe and efficient LD was performed under sharp fluorescent imaging obtained by intravenous injection of ICG 1 hour before cyst fenestration.
Cytochrome P450 1A2 is the most important enzyme for hepatic metabolism of the metamizole metabolite 4‐methylaminoantipyrine
Authors: Bachmann Fabio , Meyer zu Schwabedissen Henriette E. , Duthaler Urs , Krähenbühl Stephan 
Published: October 2021

AimsMetamizole (dipyrone) is a prodrug not detectable in serum or urine after oral ingestion. The primary metabolite, 4‐methylaminoantipyrine (4‐MAA), can be N‐demethylated to 4‐aminoantipyrine (4‐AA) or oxidized to 4‐formylaminoantipyrine (4‐FAA) by cytochrome P450 (CYP)‐dependent reactions. We aimed to identify the CYPs involved in 4‐MAA metabolism and to quantify the effect of CYP inhibition on 4‐MAA metabolism.MethodsWe investigated the metabolism of 4‐MAA in vitro using CYP expressing supersomes and the pharmacokinetics of metamizole in the presence of CYP inhibitors in male subjects.ResultsThe experiments in supersomes revealed CYP1A2 as the major CYP for 4‐MAA N‐demethylation and 4‐FAA formation with CYP2C19 and CYP2D6 contributing to N‐demethylation. In the clinical study, we investigated the influence of ciprofloxacin (CYP1A2 inhibitor), fluconazole (CYP2C19 inhibitor) and the combination ciprofloxacin/fluconazole on the pharmacokinetics of metamizole in n = 12 male subjects in a randomized, placebo‐controlled, double‐blind study. The geometric mean ratios for the area under the concentration–time curve of 4‐MAA after/before treatment were 1.17 (90% CI 1.09–1.25) for fluconazole, 1.51 (90% CI 1.42–1.60) for ciprofloxacin and 1.92 (90% CI 1.81–2.03) for ciprofloxacin/fluconazole. Fluconazole increased the half‐life of 4‐MAA from 3.22 hours by 0.47 hours (95% CI 0.13–0.81, P < .05), ciprofloxacin by 0.69 hours (95% CI 0.44–0.94, P < .001) and fluconazole/ciprofloxacin by 2.85 hours (95% CI 2.48–3.22, P < .001).ConclusionCYP1A2 is the major CYP for the conversion of 4‐MAA to 4‐AA and 4‐FAA. The increase in 4‐MAA exposure by the inhibition of CYP1A2 and by the combination CYP1A2/CYP2C19 may be relevant for dose‐dependent adverse reactions of 4‐MAA.
Language not auditory experience is related to parent‐reported executive functioning in preschool‐aged deaf and hard‐of‐hearing children
Authors: Goodwin Corina , Carrigan Emily , Walker Kristin , Coppola Marie 
Published: October 2021

AbstractMuch research has found disrupted executive functioning (EF) in deaf and hard‐of‐hearing (DHH) children; while some theories emphasize the role of auditory deprivation, others posit delayed language experience as the primary cause. This study investigated the role of language and auditory experience in parent‐reported EF for 123 preschool‐aged children (Mage = 60.1 months, 53.7% female, 84.6% White). Comparisons between DHH and typically hearing children exposed to language from birth (spoken or signed) showed no significant differences in EF despite drastic differences in auditory input. Linear models demonstrated that earlier language exposure predicted better EF (β = .061–.341), while earlier auditory exposure did not. Few participants exhibited clinically significant executive dysfunction. Results support theories positing that language, not auditory experience, scaffolds EF development.
Cross‐sectional cohort study on the use of mouthguards by children playing Gaelic football in Ireland
Authors: Shore Elaine , O'Connell Anne C. 
Published: October 2021

AbstractBackground/AimsUp to 40% of dental injuries in children occur during sports and may be prevented by using mouthguards (MG). The use of mouthguards is mandatory in some sporting organizations. Knowledge of the benefits of protection does not always result in mouthguard use. The aim of this observational cross‐sectional cohort study was to measure and compare knowledge of 9–16‐year‐old Gaelic football players and their parents on MG use and compliance with MG rules.Materials and MethodsA convenience sample of players and their parents was identified and were assessed at their sports facility. Parents completed a questionnaire while children were asked standardized questions and MG type was verified by a dentist. Data were analysed using descriptive statistics and binary logistic regression analysis for comparison.ResultsOne hundred and twenty‐one children with 118 parents participated in the study. According to players, MG use during competition (N = 119, 99.2%) was greater than during training (N = 97, 80.8%). As age increased, children were less likely to comply with MG rules during training (OR =0.18, p < .001). Children played a median of 2 contact sports (IQR = 1). Only 32 parents (27.1%) and 17 children (14%) reported that the child wore a MG for all sports. Only four children (3.8%) had a custom MG even though most parents (N = 87, 73.7%) believed that they provided superior protection. Knowledge of players and their parents on how to care for the MG was variable.ConclusionCompliance with the Gaelic Atheletic Association's MG rules was lower during training than competition. Children were less likely to comply with MG rules during training as they grew older. Most parents believed a custom MG would best protect their child's teeth, yet few children had a custom MG. Players and parents had variable knowledge in relation to MG hygiene.
Post hoc analysis of a phase 3, multicenter, open‐label study of cenobamate for treatment of uncontrolled focal seizures: Effects of dose adjustments of concomitant antiseizure medications
Authors: Rosenfeld William E. , Abou‐Khalil Bassel , Aboumatar Sami , Bhatia Perminder , Biton Victor , Krauss Gregory L. , Sperling Michael R. , Vossler David G. , Klein Pavel , Wechsler Robert 
Published: October 2021

AbstractObjectiveTo report post hoc results on how adjustments to baseline antiseizure medications (ASMs) in a subset of study sites (10 US sites) from a long‐term, open‐label phase 3 study of adjunctive cenobamate affected tolerability, efficacy, and retention.MethodsPatients with uncontrolled focal seizures taking stable doses of one to three ASMs were administered increasing doses of cenobamate (12.5, 25, 50, 100, 150, 200 mg/day) over 12 weeks at 2‐week intervals (target dose = 200 mg/day). Further increases to 400 mg/day by 50 mg/day biweekly increments were allowed during maintenance phase. Dose adjustments of cenobamate and concomitant ASMs were allowed. Data were assessed until last visit, at data cut‐off, on or after September 1, 2019.ResultsA total of 240 patients meeting eligibility criteria were assessed (median [max] exposure 30.2 [43.0] months), with 177 patients continuing cenobamate at data cut‐off. Most common baseline concomitant ASMs were lacosamide, levetiracetam, lamotrigine, zonisamide, and clobazam. For most baseline concomitant ASMs, ~70% of patients taking that ASM were continuing cenobamate at data cut‐off. Patients continuing cenobamate had greater mean ASM dose reductions and percent dose changes from baseline vs those who discontinued. Of patients continuing cenobamate, 24.6% discontinued one or more concomitant ASMs completely. Dose decreases for all concomitant ASMs generally occurred during titration or early maintenance phases and were mostly due to central nervous system (CNS)–related adverse events such as somnolence, dizziness, unsteady gait, and fatigue. Responder rates from ≥50% through 100% for patients continuing cenobamate were generally similar regardless of concomitant ASMs (of those most commonly taken), with ~81% being ≥50% responders and ~12% achieving 100% seizure reduction in the maintenance phase, which lasted up to 40.2 (median = 29.5) months.SignificanceConcomitant ASM dose reductions were associated with more patients remaining on cenobamate. This is likely due to efficacy and improved tolerability, with overall reduced concomitant drug burden in patients with uncontrolled seizures despite taking one to three baseline concomitant ASMs.
Analysing stable feature selection through an augmented marine predator algorithm based on opposition‐based learning
Authors: Balakrishnan Kulanthaivel , Dhanalakshmi Ramasamy , Mahadeo Khaire Utkarsh 
Published: October 2021

AbstractRetrieving the relevant information from the high‐dimensional dataset enhances the classification accuracy of a predictive model. This research critique has devised an improved marine predator algorithm based on opposition learning for stable feature selection to overcome the problem of high‐dimensionality. Marine predator algorithm is a population‐based meta‐heuristics optimization algorithm that works on the ‘survival‐of‐the‐fittest’ theory. Classical marine predator algorithm explores the search space merely in one direction, affecting its converging capacity while being responsible for stagnation at local minima. The proposed opposition‐based learning nuances enhance the exploration capacity of marine predator algorithm and productively converges the model to global optima. The proposed OBL‐based marine predator algorithm selects stable, substantial elements from six different high‐dimensional microarray datasets. The performance of the proposed method is investigated using five predominantly used classifiers. From the result, it is understood that the proposed approach outperforms other conventional feature selection techniques in terms of converging capability, classification accuracy, and stable feature selection.