bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic accuracy of neutrophil counts in histopathological tissue analysis in periprosthetic joint infection using the ICM, IDSA, and EBJIS criteria
Authors: Sigmund Irene K. , McNally Martin A. , Luger Markus , Böhler Christoph , Windhager Reinhard , Sulzbacher Irene 
Published: August 2021

Aims Histology is an established tool in diagnosing periprosthetic joint infections (PJIs). Different thresholds, using various infection definitions and histopathological criteria, have been described. This study determined the performance of different thresholds of polymorphonuclear neutrophils (≥ 5 PMN/HPF, ≥ 10 PMN/HPF, ≥ 23 PMN/10 HPF) , when using the European Bone and Joint Infection Society (EBJIS), Infectious Diseases Society of America (IDSA), and the International Consensus Meeting (ICM) 2018 criteria for PJI. Methods A total of 119 patients undergoing revision total hip (rTHA) or knee arthroplasty (rTKA) were included. Permanent histology sections of periprosthetic tissue were evaluated under high power (400× magnification) and neutrophils were counted per HPF. The mean neutrophil count in ten HPFs was calculated (PMN/HPF). Based on receiver operating characteristic (ROC) curve analysis and the z-test, thresholds were compared. Results Using the EBJIS criteria, a cut-off of ≥ five PMN/HPF showed a sensitivity of 93% (95% confidence interval (CI) 81 to 98) and specificity of 84% (95% CI 74 to 91). The optimal threshold when applying the IDSA and ICM criteria was ≥ ten PMN/HPF with sensitivities of 94% (95% CI 79 to 99) and 90% (95% CI 76 to 97), and specificities of 86% (95% CI 77 to 92) and 92% (95% CI 84 to 97), respectively. In rTKA, a better performance of histopathological analysis was observed in comparison with rTHA when using the IDSA criteria (p < 0.001). Conclusion With high accuracy, histopathological analysis can be supported as a confirmatory criterion in diagnosing periprosthetic joint infections. A threshold of ≥ five PMN/HPF can be recommended to distinguish between septic and aseptic loosening, with an increased possibility of detecting more infections caused by low-virulence organisms. However, neutrophil counts between one and five should be considered suggestive of infection and interpreted carefully in conjunction with other diagnostic test methods. Cite this article: Bone Joint Res 2021;10(8):536–547.
Association between surgical wait time and hospital length of stay in primary total knee and hip arthroplasty
Authors: Seddigh Shahriar , Lethbridge Lynn , Theriault Patrick , Matwin Stan , Dunbar Michael J. 
Published: August 2021

Aims In countries with social healthcare systems, such as Canada, patients may experience long wait times and a decline in their health status prior to their operation. The aim of this study is to explore the association between long preoperative wait times (WT) and acute hospital length of stay (LoS) for primary arthroplasty of the knee and hip. Methods The study population was obtained from the provincial Patient Access Registry Nova Scotia (PARNS) and the Canadian national hospital Discharge Access Database (DAD). We included primary total knee and hip arthroplasties (TKA, THA) between 2011 and 2017. Patients waiting longer than the recommended 180 days Canadian national standard were compared to patients waiting equal or less than the standard WT. The primary outcome measure was acute LoS postoperatively. Secondarily, patient demographics, comorbidities, and perioperative parameters were correlated with LoS with multivariate regression. Results A total of 11,833 TKAs and 6,627 THAs were included in the study. Mean WT for TKA was 348 days (1 to 3,605) with mean LoS of 3.6 days (1 to 98). Mean WT for THA was 267 days (1 to 2,015) with mean LoS of 4.0 days (1 to 143). There was a significant increase in mean LoS for TKA waiting longer than 180 days (2.5% (SE 1.1); p = 0.028). There was no significant association for THA. Age, sex, surgical year, admittance from home, rural residence, household income, hospital facility, the need for blood transfusion, and comorbidities were all found to influence LoS. Conclusion Surgical WT longer than 180 days resulted in increased acute LoS for primary TKA. Meeting a shorter WT target may be cost-saving in a social healthcare system by having shorter LoS. Cite this article: Bone Jt Open 2021;2(8):679–684.
High-sensitivity methane sensor composed of photonic quasi-crystal fiber based on surface plasmon resonance
Authors: Liu Qiang , Zhao Jin , Sun Yudan , Liu Wei , Liu Chao , Lv Jingwei , Lv Tingting , Jiang Yu , Li Binwen , Wang Famei , Sun Tao , Chu Paul K 
Published: August 2021

A photonic quasi-crystal fiber (PQF) methane sensor based on surface plasmon resonance (SPR) is designed and described. The double-side polished six-fold photonic quasi-crystal fiber coated with a silver film produces enhanced SPR effects and sensitivity. A nanostructured thin film with cryptophane-E-doped polysiloxane is deposited on silver as the methane-sensitive surface layer and to mitigate oxidation of silver. The sensor is analyzed and optimized numerically by the full-vector finite element method. For methane concentrations in the range of 0% to 3.5%, the maximum sensitivity of the sensor is 8 nm/%, and the average sensitivity is 6.643 nm/%. Compared to traditional gas sensors, this sensor provides accurate sensing of methane besides offering advantages such as the low cost, miniaturized size, online monitoring, and immunity to electromagnetic field interference.
Ultra-small InGaN green micro-light-emitting diodes fabricated by selective passivation of p-GaN
Authors: Zhuang Zhe , Iida Daisuke , Velazquez-Rizo Martin , Ohkawa Kazuhiro 
Published: August 2021

Here, we proposed fabricating ultra-small InGaN-based micro-light-emitting diodes (µLEDs). The selective p-GaN areas were intentionally passivated using a

H

2

plasma treatment and served as the electrical isolation regions to prevent the current from injecting into the InGaN quantum wells below. Three kinds of green µLEDs, two squircle shapes with widths of 5 and 4 µm and one circular shape with a diameter of 2.7 µm, were successfully realized. The current-voltage characteristics indicate that the series resistance and the turn-on voltage increase as the dimension of the µLED decreases. This originates from the diffusion of the hydrogen atoms into the unexpected conductive p-GaN area. The light output power density and the calculated external quantum efficiency of the µLEDs from a 5-µm-squircle to a 2.7-µm-circle were enhanced by 10−20% when compared to

98

×

98

µ

m

2

µLEDs that were fabricated using mesa etching.
Visible-blind and flexible metal-semiconductor-metal ultraviolet photodetectors based on sub-10-nm thick silver interdigital electrodes
Authors: He Xie , Yang Liu , He Sailing 
Published: August 2021

We propose and experimentally demonstrate a distinct visible-blind and flexible metal–semiconductor–metal ultraviolet (UV) photodetector (PD) based on sub-10-nm thick silver interdigital electrodes. The transparent PD with 7-nm thick electrodes shows enhanced visible transmittance (80%) in average and achieves greatly improved responsivity (60.5 mA/W), and detectivity (

1.75

×

10

10

Jones) at 5 V under 380-nm illumination, compared with its opaque counterpart. It is as fast as the opaque PD with short rise and fall times (22.4 and 11.5 ms) and shows good flexibility. All the properties are comparable or superior to many reported transparent UV PDs, mainly attributed to the broad high UV-visible transmittance and the high conductivity of the ultrathin silver film.
Cadherin and Wnt signaling pathways as key regulators in diabetic nephropathy
Authors: Tziastoudi Maria , Tsezou Aspasia , Stefanidis Ioannis 
Published: August 2021

AimA recent meta-analysis of genome-wide linkage studies (GWLS) has identified multiple genetic regions suggestive of linkage with DN harboring hundreds of genes. Moving this number of genetic loci forward into biological insight is truly the next step. Here, we approach this challenge with a gene ontology (GO) analysis in order to yield biological and functional role to the genes, an over-representation test to find which GO terms are enriched in the gene list, pathway analysis, as well as protein network analysis.MethodGO analysis was performed using protein analysis through evolutionary relationships (PANTHER) version 14.0 software and P-values less than 0.05 were considered statistically significant. GO analysis was followed by over-representation test for the identification of enriched terms. Statistical significance was calculated by Fisher’s exact test and adjusted using the false discovery rate (FDR) for correction of multiple tests. Cytoscape with the relevant plugins was used for the construction of the protein network and clustering analysis.ResultsThe GO analysis assign multiple GO terms to the genes regarding the molecular function, the biological process and the cellular component, protein class and pathway analysis. The findings of the over-representation test highlight the contribution of cell adhesion regarding the biological process, integral components of plasma membrane regarding the cellular component, chemokines and cytokines with regard to protein class, while the pathway analysis emphasizes the contribution of Wnt and cadherin signaling pathways.ConclusionsOur results suggest that a core feature of the pathogenesis of DN may be a disturbance in Wnt and cadherin signaling pathways, whereas the contribution of chemokines and cytokines need to be studied in additional studies.
Association between the severity of new-onset depression and unmet healthcare needs of South Korean adults
Authors: Kim Su Yeon , Jeong Wonjeong , Park Eun-Cheol , Park Sohee , Jang Sung-In 
Published: August 2021

Objectives
Identifying whether the demand for medical services is catered to is an important issue. Given that depression is a major contributor to the overall global burden of disease, it could affect the use of healthcare. This study aims to examine the association between the severity of new-onset depression and unmet healthcare needs among South Korean adults.

Methods
Data from 15,588 participants, derived from the 2014, 2016, and 2018 Korean National Health and Nutrition Examination Survey, were examined. Only individuals who were not diagnosed with depression was included to exclude those who visited hospitals to treat depression or were experiencing unmet healthcare needs due to depression. Depression was measured using the Patient Health Questionnaire-9 and unmet healthcare needs acted as the dependent variable. A multiple/multinomial logistic regression analysis was built to analyze the association between the variables.

Results
Individuals with severe depression had a higher risk of having unmet healthcare needs compared to those without (men: adjusted OR = 2.05, 95% CI = 1.40–3.00; women: adjusted OR = 2.20, 95% CI = 1.72–2.82). White-collar men with severe depression also had a higher risk of having unmet healthcare needs (adjusted OR = 9.72, 95% CI = 4.73–20.00). Individuals with severe depression had a higher risk of having unmet healthcare needs due to economic hardship than those without depression (men: adjusted OR = 3.01, 95% CI = 1.76–5.14, women: adjusted OR = 2.93, 95% CI = 1.96–4.38).

Conclusions
This study identified a significant relationship between the severity of new-onset depression and the risk of having unmet healthcare needs among South Korean adults. Our study suggests that having severe depression contributed to a higher risk of unmet healthcare needs. Proper care to manage depression can be promoted through future intervention programs that alleviate the risk of having unmet healthcare needs.
Development and psychometric evaluation of the Decision Tool Anxiety Disorders, OCD and PTSD (DTAOP): Facilitating the early detection of patients in need of highly specialized care
Authors: van Krugten Frédérique C. W. , Kaddouri Meriam , Goorden Maartje , van Balkom Anton J. L. M. , Berretty Ed W. , Cath Daniëlle C. , Hendriks Gert-Jan , Matthijssen Suzy J. M. A. , Visser Henny A. D. , van Vliet Irene M. , Brouwer Werner B. F. , Hakkaart-van Roijen Leona 
Published: August 2021

Background
Early identification of patients with an anxiety disorder, obsessive-compulsive disorder (OCD), or post-traumatic stress disorder (PTSD) in need of highly specialized care could facilitate the selection of the optimal initial treatment in these patients. This paper describes the development and psychometric evaluation of the Decision Tool Anxiety Disorders, OCD and PTSD (DTAOP), which aims to aid clinicians in the early identification of patients with an anxiety disorder, OCD, or PTSD in need of highly specialized mental healthcare.

Methods
A systematic literature review and a concept mapping procedure were carried out to inform the development of the DTAOP. To evaluate the psychometric properties of the DTAOP, a cross-sectional study in 454 patients with a DSM-IV-TR anxiety disorder was carried out. Feasibility was evaluated by the completion time and the content clarity of the DTAOP. Inter-rater reliability was assessed in a subsample of 87 patients. Spearman’s rank correlation coefficients between the DTAOP and EuroQol five-dimensional questionnaire (EQ-5D-5L) scores were computed to examine the convergent validity. Criterion validity was assessed against independent clinical judgments made by clinicians.

Results
The average time required to complete the eight-item DTAOP was 4.6 min and the total DTAOP was evaluated as clear in the majority (93%) of the evaluations. Krippendorff’s alpha estimates ranged from 0.427 to 0.839. Based on the qualitative feedback, item wording and instructions were improved. As hypothesized, the DTAOP correlated negatively with EQ-5D-5L scores. The area under the curve was 0.826 and the cut-off score of ≥4 optimized sensitivity (70%) and specificity (71%).

Conclusions
The DTAOP demonstrated excellent feasibility and good validity, but weak inter-rater reliability. Based on the qualitative feedback and reliability estimates, revisions and refinements of the wording and instructions were made, resulting in the final version of the DTAOP.
“Donor milk banking: Improving the future”. A survey on the operation of the European donor human milk banks
Authors: Kontopodi Eva , Arslanoglu Sertac , Bernatowicz-Lojko Urszula , Bertino Enrico , Bettinelli Maria Enrica , Buffin Rachel , Cassidy Tanya , van Elburg Ruurd M. , Gebauer Corina , Grovslien Anne , Hettinga Kasper , Ioannou Ioanna , Klotz Daniel , Mileusnić-Milenović Radmila , Moro Guido E. , Picaud Jean-Charles , Stahl Bernd , Weaver Gillian , van Goudoever Johannes B. , Wesolowska Aleksandra 
Published: August 2021

Background
Provision of donor human milk is handled by established human milk banks that implement all required measures to ensure its safety and quality. Detailed human milk banking guidelines on a European level are currently lacking, while the information available on the actual practices followed by the European human milk banks, remains limited. The aim of this study was to collect detailed data on the actual milk banking practices across Europe with particular emphasis on the practices affecting the safety and quality of donor human milk.

Materials and methods
A web-based questionnaire was developed by the European Milk Bank Association (EMBA) Survey Group, for distribution to the European human milk banks. The questionnaire included 35 questions covering every step from donor recruitment to provision of donor human milk to each recipient. To assess the variation in practices, all responses were then analyzed for each country individually and for all human milk banks together.

Results
A total of 123 human milk banks completed the questionnaire, representing 85% of the European countries that have a milk bank. Both inter- and intra-country variation was documented for most milk banking practices. The highest variability was observed in pasteurization practices, storage and milk screening, both pre- and post-pasteurization.

Conclusion
We show that there is a wide variability in milk banking practices across Europe, including practices that could further improve the efficacy of donor human milk banking. The findings of this study could serve as a tool for a global discussion on the efficacy and development of additional evidence-based guidelines that could further improve those practices.
Changes in leisure-time physical activity during the adult life span and relations to cardiovascular risk factors—Results from multiple Swedish studies
Authors: Lind Lars , Zethelius Björn , Lindberg Eva , Pedersen Nancy L. , Byberg Liisa 
Published: August 2021

Objective
To evaluate how self-reported leisure-time physical activity (PA) changes during the adult life span, and to study how PA is related to cardiovascular risk factors using longitudinal studies.

Methods
Several Swedish population-based longitudinal studies were used in the present study (PIVUS, ULSAM, SHE, and SHM, ranging from hundreds to 30,000 participants) to represent information across the adult life span in both sexes. Also, two cross-sectional studies were used as comparison (EpiHealth, LifeGene). PA was assessed by questionnaires on a four or five-level scale.

Results
Taking results from several samples into account, an increase in PA from middle-age up to 70 years was found in males, but not in females. Following age 70, a decline in PA was seen. Young adults reported both a higher proportion of sedentary behavior and a higher proportion high PA than the elderly. Females generally reported a lower PA at all ages.
PA was mainly associated with serum triglycerides and HDL-cholesterol, but also weaker relationships with fasting glucose, blood pressure and BMI were found. These relationships were generally less strong in elderly subjects.

Conclusion
Using data from multiple longitudinal samples the development of PA over the adult life span could be described in detail and the relationships between PA and cardiovascular risk factors were portrayed. In general, a higher or increased physical activity over time was associated with a more beneficial cardiovascular risk factor profile, especially lipid levels.
Pulpwood green density prediction models and sampling-based calibration
Authors: Repola Jaakko , Heikkinen Juha , Lindblad Jari 
Published: August 2021

Pulpwood arriving at the mills is mainly measured by weighing. In the loading phase of forwarding and trucking, timber is weighed using scales mounted in the grapple loader. The measured weight of timber is converted into volume using a conversion factor defined as green density (kg m). At the mill, the green density factor is determined by sampling measurements, while in connection with weighing with grapple-mounted scales during transportation, fixed green density factors are used. In this study, we developed predictive regression models for the green density of pulpwood. The models were constructed separately by pulpwood assortments: pine (contains mainly L); spruce (mainly (L.) Karst.); decayed spruce; birch (mainly Ehrh. and Roth); and aspen (mainly L.). Study material was composed of the sampling-based measurements at the mills between 2013â2019. The models were specified as linear mixed models with both fixed and random parameters. The fixed effect produced the expected value of green density as a function of delivery week, storage time, and meteorological conditions during storage. The random effects allowed the model calibration by utilizing the previous sampling weight measurements. The model validation showed that the model predictions faithfully reproduced the observed seasonal variation in green density. They were more reliable than those obtained with the current practices. Even the uncalibrated (fixed) predictions had lower relative root mean squared prediction errors than those obtained with the current practices.â3Pinus sylvestrisPicea abiesBetula pubescensBetula pendulaPopulus tremula
Fee-For-Service Health Insurance and Moral Hazard of Hospitals
Authors: Jung Chan Wook , Park Sojung Carol 
Published: August 2021

Abstract
The supply-side contribution to the surge of medical expense is overlooked in the Korean health insurance market. Commonly, the demand-side is accounted for the excessive increase in medical consumption. Previous studies suggest the moral hazard or adverse selection of Fee-For-Service Health Insurance (FFS) policyholders as the source of the problem. However, this paper focuses on the moral hazard of medical institutions using Korea Health Panel (KHP) Data version 1.5 from year 2008–2016. This study finds the medical usage difference between FFS holders and non-holders were greater for clinics and local hospital visits than the visits to general hospitals or special hospitals. This implies that supply-side contributes to the ex-post moral hazard of health insurance.
A Monte Carlo study on burnup treatment in sodium-cooled reactor with Th fuel
Authors: Korkmaz M. E. , Arslan N. K. 
Published: August 2021

Abstract
Sodium Cooled Reactors is one of the Generation-IV plants selected to manage the long-lived minor actinides and to transmute the long-life radioactive elements. This study presents the comparison between two-designed SFR cores with 600 and 800 MWth total heating power. We have analyzed a conceptual core design and nuclear characteristic of SFR. Monte Carlo depletion calculations have been performed to investigate essential characteristics of the SFR core. The core calculations were performed by using the Serpent Monte Carlo code for determining the burnup behavior of the SFR, the power distribution and the effective multiplication factor. The neutronic and burn-up calculations were done by means of Serpent-2 Code with the ENDF-7 cross-sections library. Sodium Cooled Fast Reactor core was taken as the reference core for Th-232 burnup calculations. The results showed that SFR is an important option to deplete the minor actinides as well as for transmutation from Th-232 to U-233.
Large eddy fire simulation applications from nuclear industry
Authors: Sharma P. K. , Verma V. , Chattopadhyay J. , Vinod G. 
Published: August 2021

Abstract
A computational study has been carried out for predicting the behaviour of a pool fire source using the field-model based code Fire Dynamics Simulator (FDS). Time dependent velocity and temperature fields are predicted along with the resulting changes in the plume structure and its width. Firstly, a grid study was performed to find out the best grid size for this purpose. Then calculations were done which showed a very good agreement with earlier reported experimental based correlations for the temperature of the plume region. These studies have been extended to use this field-model based tools for modelling particular separate effect phenomena like puffing frequency and to validate against experimental data. There are several applications in nuclear industry like room fires, wildland fires, smoke or ash disposal, hydrogen transport in nuclear reactor containment, natural convection in building flows etc. In this paper the use of FDS with the advanced Large Eddy Simulation (LES) based CFD turbulence model is described for various applications: Fire simulation for Alpha storage, Bhabhatran teletherapy, pool fire for transport casks, fire PSA of a representative NPP, exhaust air fan buildings of a process plant and smoke dispersion in large fires around NPPs.