bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential role of vitamin D receptor-related polymorphisms in bronchopulmonary dysplasia
Authors: Abuelhamd Walaa Alsharany , Gomaa Nancy Abdel Salam , Gad Alaa , El-Wakeel Rehab 
Published: April 2021

Abstract
Background
The potential contribution of vitamin D and its receptor (VDR) to bronchopulmonary dysplasia (BPD) in preterm neonates is still unknown. The objective of the study was to test the relationship between VDR Taq 1 and Fok 1 gene polymorphisms and BPD in preterm neonates. VDR Fok 1 and Taq 1 gene polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.

Result
No statistically significant differences of genotypic distributions and allele frequencies of Fok 1 and Taq 1 VDR polymorphisms were detected between cases and controls. Moreover, no risk association was detected between both polymorphisms and BPD development in preterm neonates. Homozygous mutant (ff) genotype was the least frequent genotype among BPD and non-BPD groups (2.6%, 13.0% respectively) (p = 0.1). The same was detected for the mutant (CC) genotype frequency in both groups (10.5% and 15.2%, respectively). However, Taq 1 VDR polymorphism was significantly associated with the severity of BPD, as the genotypes with mutant allele C (CC +CT) were more frequent among severe cases (52.2%).

Conclusion
Fok 1and Taq 1 VDR polymorphisms have no role in BPD development in preterm neonates. However, the presence of a mutant allele of Taq 1 VDR polymorphism may be associated with a more severe form of the disease.
Distress Screening Through Patient-Reported Outcomes Measurement Information System (PROMIS) at an Academic Cancer Center and Network Site: Implementation of a Hybrid Model
Authors: Neal Joel W. , Roy Mohana , Bugos Kelly , Sharp Christopher , Galatin Peter S. , Falconer Patricia , Rosenthal Eben L. , Blayney Douglas W. , Modaressi Shiva , Robinson Ashley , Ramchandran Kavitha 
Published: April 2021

PURPOSE: Cancer care guidelines recommend regular distress screening of patients, with approximately one in three patients with cancer experiencing significant distress. However, the implementation of such programs is variable and inconsistent. We sought to assess the feasibility of implementing a hybrid electronic and paper screening tool for distress in all patients coming to a large academic cancer center and an associated integrated network site. METHODS: Patients at an academic cancer center (Stanford Cancer Center) and its associated integrated network site received either an electronic or on-paper modified Patient-Reported Outcomes Measurement Information System-Global Health questionnaire, to assess overall health and distress. We used the Reach, Effectiveness, Adoption, Implementation, and Maintenance implementation framework to test and report on the feasibility of using this questionnaire. Iterative workflow changes were made to implement the questionnaire throughout the healthcare system, including processes to integrate with existing electronic health records. RESULTS: From June 2015 to December 2017, 53,954 questionnaires representing 26,242 patients were collected. Approximately 30% of the questionnaires were completed before the visit on an electronic patient portal. The number of patients meeting the positive screen threshold remained around 40% throughout the study period. Following assessment, there were 3,763 referrals to cancer supportive services. Of note, those with a positive screen were more likely to have a referral to supportive care (odds ratio, 6.4; 95% CI, 5.8 to 6.9; P < .0001). CONCLUSION: The hybrid electronic and on-paper use of a commonly available patient-reported outcome tool, Patient-Reported Outcomes Measurement Information System-Global Health, as a large-scale distress screening method, is feasible at a large integrated cancer center.
High FGF23 Levels Failed to Predict Cardiac Hypertrophy in Animal Models of Hyperphosphatemia and Chronic Renal Failure
Authors: Moench Ian , Aravindhan Karpagam , Kuziw Joanne , Schnackenberg Christine G , Willette Robert N , Toomey John R , Gatto Gregory J 
Published: April 2021

Abstract
Increased fibroblast growth factor 23 (FGF23) levels are an independent predictor for adverse cardiac events suggesting a role as a link that drives cardiomyopathic changes in cardiorenal syndrome. The search for the underlying mechanism driving this interaction has led to the hypothesis that FGF23 causes pathogenic changes in the heart. Increased serum FGF23 has been independently shown to cause increased cardiac morbidity, mortality, and hypertrophy by signalling through FGF receptor 4. This mechanistic concept was based on preclinical studies demonstrating inhibition of FGF23 signaling through FGF4, which led to suppression of left ventricular hypertrophy and fibrosis in a 2-week rat 5/6 nephrectomy study and a 12-week (2%) high-phosphate diet mouse model in which FGF23 levels were markedly elevated. In this report, renal dysfunction was observed in the 5/6 nephrectomy model, and FGF23 levels were significantly elevated, whereas no changes in left ventricular hypertrophy were observed at 2 or 4 weeks postnephrectomy. Mice placed on a high-phosphate diet that did not cause significant renal dysfunction resulted in significantly elevated FGF23 but no changes in left ventricular hypertrophy. The in vivo studies reported here, which were performed to recapitulate the observations of FGF23 as a driver of cardiac hypertrophy, did not lend support to the FGF23-driven cardiac remodelling hypothesis.
Neurologic manifestations in hospitalized patients with COVID-19 in Mexico City
Authors: Flores-Silva Fernando Daniel , García-Grimshaw Miguel , Valdés-Ferrer Sergio Iván , Vigueras-Hernández Alma Poema , Domínguez-Moreno Rogelio , Tristán-Samaniego Dioselina Panamá , Michel-Chávez Anaclara , González-Duarte Alejandra , Vega-Boada Felipe A. , Reyes-Melo Isael , Jiménez-Ruiz Amado , Chávez-Martínez Oswaldo Alan , Rebolledo-García Daniel , Marché-Fernández Osvaldo Alexis , Sánchez-Torres Samantha , García-Ramos Guillermo , Cantú-Brito Carlos , Chiquete Erwin 
Published: April 2021

BackgroundThe coronavirus disease 2019 (COVID-19) is a systemic entity that frequently implies neurologic features at presentation and complications during the disease course. We aimed to describe the characteristics and predictors for developing in-hospital neurologic manifestations in a large cohort of hospitalized patients with COVID-19 in Mexico City.MethodsWe analyzed records from consecutive adult patients hospitalized from March 15 to June 30, 2020, with moderate to severe COVID-19 confirmed by reverse transcription real-time polymerase chain reaction (rtRT-PCR) for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Neurologic syndromes were actively searched by a standardized structured questionnaire and physical examination, confirmed by neuroimaging, neurophysiology of laboratory analyses, as applicable.ResultsWe studied 1,072 cases (65% men, mean age 53.2±13 years), 71 patients had pre-existing neurologic diseases (diabetic neuropathy: 17, epilepsy: 15, history of ischemic stroke: eight, migraine: six, multiple sclerosis: one, Parkinson disease: one), and 163 (15.2%) developed a new neurologic complication. Headache (41.7%), myalgia (38.5%), dysgeusia (8%), and anosmia (7%) were the most common neurologic symptoms at hospital presentation. Delirium (13.1%), objective limb weakness (5.1%), and delayed recovery of mental status after sedation withdrawal (2.5%), were the most common new neurologic syndromes. Age, headache at presentation, preexisting neurologic disease, invasive mechanical ventilation, and neutrophil/lymphocyte ratio ≥9 were independent predictors of new in-hospital neurologic complications.ConclusionsEven after excluding initial clinical features and pre-existing comorbidities, new neurologic complications in hospitalized patients with COVID-19 are frequent and can be predicted from clinical information at hospital admission.
Hooked on virtual social life. Problematic social media use and associations with mental distress and addictive disorders
Authors: Henzel Vincent , Håkansson Anders 
Published: April 2021

BackgroundSocial media is an important and growing part of the lives of the vast majority of the global population, especially in the young. Although still a young and scarce subject, research has revealed that social media has addictive potential. The aim of this cross-sectional study was to explore the associations between problematic use of social media and mental distress, problematic gaming and gambling, within the Swedish general population.MethodsData from 2,118 respondents was collected through self-report questions on demographics and validated scales measuring addiction-like experiences of social media, problem gaming, problem gambling, and mental distress. Associations were analyzed in unadjusted analyses and–for variables not exceedingly inter-correlated–in adjusted logistic regression analyses.ResultsIn adjusted analyses, problematic use of social media demonstrated a relationship with younger age, time using instant messaging services, and mental distress, but not with education level, occupational status, or with treatment needs for alcohol or drug problems. Behavioral addictions (internet, gaming and gambling) were substantially inter-correlated, and all were associated with problematic use of social media in unadjusted analyses.ConclusionsSocial media use is associated with other addictive behaviors and mental distress. While factors of causality remain to be studied, these insights can motivate healthcare professionals to assess social media habits, for example in individuals suffering from issues concerning gambling, gaming or mental health.
Evidence of the effect of primary care expansion on hospitalizations: Panel analysis of 143 municipalities in the Brazilian Amazon
Authors: Campelo Barroso Carneiro Vânia Cristina , Ribeiro de Oliveira Paulo de Tarso , Rassy Carneiro Saul , Cardoso Maciel Marinalva , da Silva Pedroso Janari 
Published: April 2021

Background
The Family Health Strategy (FHS) became consolidated as a primary care model and gatekeeper for the Unified Health System (Sistema Único de Saúde, SUS) in the Brazil and it is considered one of the largest primary health care programmes in the world. Its rapid expansion allowed the SUS to meet the changing health care needs of the population remote localities of Brazilian municipalities.

Methods
In the present study, exploratory data analysis was performed using modelling to provide a general overview of the study and to delineate possible structural characteristics of the cross-sectional time-series data. Panel regression methods were used to assess the association between FHS coverage and ambulatory care-sensitive hospitalizations (ACSH rates) in the municipalities of Pará, in the Brazilian Amazon, from 2008 to 2017.

Results
The results showed strong evidence for the association between FHS coverage and ACSH rates, including reductions of 22% in preventable hospitalizations and 15% in hospital expenses that were directly linked to the 40% increase in FHS population coverage during the evaluated period. This expansion of primary care has mainly benefitted areas that are difficult to access and populations that were previously deprived of health care in the vast Amazon territory.

Conclusions
The findings of this study show that the increase of the expansion of primary care reduces the preventable hospitalization and the hospital expenses. This reinforces the need for public protection of the health of populations at risk and the positive impacts of primary care in the Brazilian Amazon.
Movement performance and movement difficulties in typical school-aged children
Authors: Jaikaew Rujira , Satiansukpong Nuntanee 
Published: April 2021

IntroductionDevelopmental Coordination Disorder (DCD) is an impairment of executive motor skills. Children aged 7–10 years gradually develop effective movement that enables smooth performance in various daily self-care, academic and sport activities. The purpose of this study was to examine whether the Movement Assessment Battery for Children-Second Edition-Age Band 2, (MABC2-AB2), which is a western standardized test, could be used in Thai children for differentiating between movement performance and movement difficulties.MethodThree hundred and sixty typical Thai children aged 7–10 years old were recruited from three primary schools in Chiang Mai district, Thailand. The participants were divided into four age groups and tested using the Movement Assessment Battery for Children-Second Edition-Age Band 2-Thai version (MABC2-AB2-T).ResultsManual Dexterity, Aiming and Catching, and Balance rose with age increment. Older participants had better movement performance than younger ones. The results showed that 91.11 percent of the participants had typical movement, while 3.61 and 5.28 percent of them had movement difficulty and movement at risk, respectively. In addition, three test items: Drawing Trail, Walking Heel to Toe Forward, and Hopping on Mats had a ceiling effect when used for Thai children.ConclusionThe MABC2-AB2-T could be used to assess movement performance and movement difficulties in Thai children. About 9 percent of typical Thai children aged 7–10 years old needed early intervention. Administration of the three test items may need to be revised.
Establishing how social capital is studied in relation to cardiovascular disease and identifying gaps for future research—A scoping review protocol
Authors: Parker Marie , Fang Xiangming , Self-Brown Shannon Renee , Rahimi Ali 
Published: April 2021

Introduction
Though the relationship between social capital and health has been widely studied, the evidence of this relationship in cardiovascular disease is limited, with varied and inconsistent measures. This scoping review seeks to address this gap by answering the following questions: (1) How has social capital been characterized and measured in the literature related to cardiovascular disease? and (2) What gaps exist in the evaluation of the relationship between social capital and cardiovascular disease?

Materials and methods
A scoping review will be used to answer the research questions. The scoping review will apply established methods described by Arksey and O’Malley, Levac and colleagues, and the Joanne Briggs Institute: (1) identifying the research question(s); (2) identifying relevant studies; (3) selecting the studies; (4) charting the data; and (5) collating, summarizing, and reporting the results.

Results
Our findings will be reported in accordance with the guidance provided in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement.

Discussion
The synthesis of this evidence base is intended to provide a framework for how social capital has been defined and measured in the cardiovascular literature, with additional guidance for future research and evaluation. The findings will be disseminated through peer-reviewed publication and presentations at relevant seminars.
Knowledge, attitude and practice of cervical cancer screening among women infected with HIV in Africa: Systematic review and meta-analysis
Authors: Bogale Agajie Likie , Teklehaymanot Tilahun , Haidar Ali Jemal , Kassie Getnet Mitike 
Published: April 2021

Background
To establish successful strategies and increasing the utilization of preventive services, there is a need to explore the extent to which the general female population is aware and use the service for cervical cancer-screening among women infected with HIV in Africa. Available evidences in this regard are controversial and non-conclusive on this potential issue and therefore, we estimated the pooled effect of the proportion of knowledge, attitude and practice of HIV infected African women towards cervical cancer screening to generate evidence for improved prevention strategies.

Methods
We applied a systematic review and meta-analysis of studies conducted in Africa and reported the proportion of knowledge, attitude and practice towards cervical cancer screening. We searched electronic databases: PubMed/Medline, SCOPUS, ScienceDirect, Web of science, Cumulative Index of Nursing and allied Health Sciences (CINAHL) and Google scholar databases to retrieve papers published in English language till August 2020. We used random-effects model to estimate the pooled effect, and funnel plot to assess publication bias. The registration number of this review study protocol is CRD42020210879.

Results
In this review, we included eight published papers comprising 2,186 participants. The estimated pooled proportion of knowledge of the participants was 43.0% (95%CI:23.0–64.0) while the pooled estimates of attitudes and practices were 38.0% (95%CI: 1.0–77.0) and 41.0% (95%CI: 4.0–77.0), respectively. The proportion of the outcome variables were extremely heterogeneous across the studies with I2> 98%).

Conclusion
The pooled estimates of knowledge, attitude and practice were lower than other middle income countries calls for further activities to enhance the uptake of the services and establish successful strategies.
The Initial Education of the Pedagogue and the Technologies in the Theoretical Perspective of the TPACK Model
Authors: Purificação Marcelo Máximo , Amado Nélia Maria Pontes , Santos Jeová Braga dos , Oliveira Pedro Márcio Pinto de , Borges Dayane Silva , Carrijo Danielly Oliveira 
Published: April 2021

Abstract: This qualitative and bibliographic study offers a discussion based on some of the work on teacher training and ICT developed in Brazil. The results of this research suggest the importance of understanding and the pedagogical use of technology in the formation of mathematics teachers in the early years, warning that the use of technology in teaching practice is walking in a Risk Zone, with all the issues involved, but recognizing that there is a great potential for improving teaching practice” (OLIVEIRA, 2008, p. 82). In this theoretical direction, Mishra and Koehler (2006) observe several types of knowledge that are important for the teacher in order to increase the climate of learning permeable to ICT (RICHIT, 2015).
Keywords: Professional development; TPACK model; Mathematical knowledge.
Indoor and Outdoor Measurements of Particulate Matter Concentrations: A Case Study Košice-Sever, Slovakia
Authors: Burdová Eva Krídlová , Vilčeková Silvia , Kapalo Peter 
Published: April 2021

Abstract
An occurrence of indoor particulate matters largely depends on outdoor pollution and its transportation indoors as well as on the presence of indoor pollution sources. Pollutants can flow from outdoor to indoor or indoor to outdoor under various conditions e.g. contribution of indoor pollutants to outdoor (in rural location with biomass fuel used for cooking) or outdoor to indoor in urban locations. This study aims to carry out an experimental investigation of particulate matter (PM) concentrations, temperature, humidity and air velocity during three days in winter season in Košice-Sever, Slovakia. Values of outdoor PM10 concentrations ranged from 12.58 μg/m3 to 6,627.51 μg/m3. Extremely high concentrations of PM10 were found near the traffic. Outdoor mean value of PM2.5 (21.82 μg/m3) did not exceed a permissible value of 25 μg/m3. Overloads by PM10 concentrations denote almost 108% and 2,270%. The indoor/outdoor (I/O) ratio was <1 for all fractions of particulate matters.
Effect of Fiber Distribution on the Mechanical Behavior in Bending of Self-Compacting Mortars
Authors: Kheddache Lynda , Chahour Kahina , Safi Brahim 
Published: April 2021

Abstract
The purpose of this work is to assess the steel fiber distribution effect on physical and mechanical properties of self-compacting mortar. An experimental study was conducted to see the fiber distribution during the implementation of self-compacting mortars that are fluid and on mechanical behavior in bending tensile strength. A method of placing self-compacting mortar in the molds has been developed to highlight the distribution of fibers in the cementitious matrix. The mortars are placed in prismatic molds in three layers. The amount of steel fibers differs from one layer to another. A total quantity of 90 kg /m3 was distributed in prismatic molds of dimensions 40x40x160 mm3. Straight and hooked ends steel fibers were used. The characteristics of mortars containing both types of fibers in the fresh and hardened state were measured and compared to those of self-compacting mortar without fibers. The pouring by layer allowed us to deduce that the distribution of metallic fibers has a significant effect on the hardened properties of the mortar. Indeed, the mechanical strength of the fiber-reinforced mortar depends on the nature and distribution of fibers in the cementitious matrix (mortar). A gain in bending tensile strength of 71.83% was recorded for self-compacting mortars elaborated with hooked end fibers and 52.11% for those containing straight steel fibers. Indeed, mortars containing entirely the same dosage of steel fibers (90 kg/m3) have a bending tensile strength that varies according to the fibers dosage by layers. Mortar samples with higher fiber content in the lower layer have a higher bending tensile strength than other samples with a higher fiber layer in the middle or layer above. However, it should be noted that steel fibers with hooks are much more effective than those without hooks. Indeed, the effect of fiber distribution is more significant for fibers without hooks because the hooks can slow down the movement of the fibers during the pouring of the mortar. The variation of the dosages per layer generated a difference in the deflection values for the mortars. The deflection is much higher for fiber-reinforced mortars (with hooks) compared to fiber-reinforced mortars without hooks.
The effects of a 12-week different exercise programmes on physical anxiety and some physical parameters of women with osteoporosis
Authors: Korkmaz Nimet , Arabaci Ramiz , Topsaç Mine 
Published: April 2021

Abstract

Study aim: The aim of this study was to determine the effects of 12 weeks of Pilates, coordination and strength exercise on the osteoporosis patient’s social physical anxiety and physical parameters.

Methods: Three groups of patients practiced 12 weeks of exercises, 3 day/week, 60 minutes/day. Each group performed a different set of exercises. Those are Pilates, coordination and strength exercise. For each group before and after program the social physical anxiety index and physical parameters were measured.

Results: The paired sample T test shows that the Pilates and Coordination group has significant improvement regarding the participants’ social physical anxiety. On the other hand the strength exercises have a bigger impact on the physical parameters of the patients.

Conclusion: The exercise programs improve the physical fitness capacity of the female patients with osteoporosis. Social physical anxiety decreases with increasing self-confidence, as patients feel their body muscles have become stronger.