bluuebunny/crossref_metadata_2025_split huggingface dataset:
An architecture governance approach for Agile development by tailoring the Spotify model
Authors: Salameh Abdallah , Bass Julian M. 
Published: June 2021

AbstractThe role of software architecture in large-scale Agile development is important because several teams need to work together to release a single software product while helping to maximise teams’ autonomy. Governing and aligning Agile architecture across autonomous squads (i.e., teams), when using the Spotify model, is a challenge because the Spotify model lacks practices for addressing Agile architecture governance. To explore how software architecture can be governed and aligned by scaling the Spotify model, we conducted a longitudinal embedded case study in a multinational FinTech organisation. Then, we developed and evaluated an approach for architectural governance by conducting an embedded case study. The collected data was analysed using Thematic Analysis and informed by selected Grounded Theory techniques such as memoing, open coding, constant comparison, and sorting. Our approach for architectural governance comprises an organisational structure change and an architecture change management process. The benefits reported by the practitioners include devolving architectural decision-making to the operational level (i.e., Architecture Owners), enhancing architectural knowledge sharing among squads, minimising wasted effort in architectural refactoring, and other benefits. The practitioners in our case study realised an improved squad autonomy by the ability to govern and align architectural decisions. We provide two key contributions in this paper. First, we present the characteristics of our proposed architectural governance approach, its evaluation, benefits, and challenges. Second, we present how the novel Heterogeneous Tailoring model was enhanced to accommodate our architectural governance approach.
Toroidal b-divisors and Monge–Ampère measures
Authors: Botero Ana María , Gil José Ignacio Burgos 
Published: June 2021

AbstractWe generalize the intersection theory of nef toric (Weil) b-divisors on smooth and complete toric varieties to the case of nef b-divisors on complete varieties which are toroidal with respect to a snc divisor. As a key ingredient we show the existence of a limit measure, supported on a balanced rational conical polyhedral space attached to the toroidal embedding, which arises as a limit of discrete measures defined via tropical intersection theory on the polyhedral space. We prove that the intersection theory of nef Cartier b-divisors can be extended continuously to nef toroidal Weil b-divisors and that their degree can be computed as an integral with respect to this limit measure. As an application, we show that a Hilbert–Samuel type formula holds for big and nef toroidal Weil b-divisors.
Digital templating for the implantation of a curved short hip stem with an anterolateral MIS approach shows gender differences in digital templating
Authors: Luger Matthias , Hochgatterer Rainer , Klotz Matthias C. , Hipmair Günter , Gotterbarm Tobias , Schauer Bernhard 
Published: June 2021

Abstract
Purpose
Digital templating shows reliable accuracy for straight stem systems. In recent years, the implantation of short stems through minimally invasive approaches has gained more popularity. Minimally invasive approaches (MIS) show the risk of undersizing femoral components. Therefore, we questioned the planning adherence for a curved short stem and a bi-hemispherical acetabular cup implanted through an anterolateral MIS approach.

Methods
A consecutive series of 964 hips (index surgery between 2014 and 2019) with Fitmore® curved short stem and Allofit/-S® acetabular cup (both ZimmerBiomet Inc, Warsaw, IN) were included. Preoperative digital templating was conducted anterior–posterior (AP) digital radiographs of the hip using mediCAD® version 5.1 (Hectec GmbH, Altdorf, Germany). The templates of acetabular and femoral components (offset option and stem size) were retrospectively evaluated for general adherence, and according to sex, BMI and planner’s experience.

Results
Planning adherence for the exact offset option was 70.6 and 21.6% for exact offset option and stem size. Adherence for acetabular cup  ± 1 size was 74.8%. A significant difference between male and female patients for the offset option could be found (p = 0.03, z = −2983). In 22.5% of male patients, an offset option one size higher and in 12.3% of female patients an offset option one size smaller than templated was used intraoperatively

Conclusion
Digital templating for the Fitmore® stem in cementless THA with a minimally invasive anterolateral approach shows comparable planning adherence to the existing literature for this cementless short stem. However, a lower planning adherence was detected compared to conventional straight stem systems. In male patients, the femoral offset is frequently undersized and in female patients frequently oversized compared to the preoperative plan. Surgeons should be aware of this difficulty in digital templating for Fitmore® hip stem.
Long-term oncologic outcomes of transanal TME compared with transabdominal TME for rectal cancer: a systematic review and meta-analysis
Authors: Moon Jae Young , Lee Min Ro , Ha Gi Won 
Published: June 2021

Abstract
Background
Transanal total mesorectal excision (TaTME) appears to have favorable surgical and pathological outcomes. However, the evidence on survival outcomes remains unclear. We performed a meta-analysis to compare long-term oncologic outcomes of TaTME with transabdominal TME for rectal cancer.

Methods
PubMed, EMBASE, and the Cochrane Library were searched. Data were pooled, and overall effect size was calculated using random-effects models. Outcome measures were overall survival (OS), disease-free survival (DFS), and local and distant recurrence.

Results
We included 11 nonrandomized studies that examined 2,143 patients for the meta-analysis. There were no significant differences between the two groups in OS, DFS, and local and distant recurrence with a RR of 0.65 (95% CI 0.39–1.09, I2 = 0%), 0.79 (95% CI 0.57–1.10, I2 = 0%), 1.14 (95% CI 0.44–2.91, I2 = 66%), and 0.75 (95% CI 0.40–1.41, I2 = 0%), respectively.

Conclusion
In terms of long-term oncologic outcomes, TaTME may be an alternative to transabdominal TME in patients with rectal cancer. Well-designed randomized trials are warranted to further verify these results.
Mental disorders among adults formerly in out-of-home care: a systematic review and meta-analysis of longitudinal studies
Authors: Seker Süheyla , Boonmann Cyril , Gerger Heike , Jäggi Lena , d’Huart Delfine , Schmeck Klaus , Schmid Marc 
Published: June 2021

AbstractWhile children and adolescents placed in child welfare or juvenile justice out-of-home care show higher prevalence rates of mental disorders compared to the general population, it remains unclear whether this pattern persists into adulthood. A quantitative synthesis of existing studies is lacking. The aim of this meta-analysis was to estimate the prevalence rates for mental disorders among adults with a foster or residential child welfare or juvenile justice care history, comparing them where possible to rates among the general population. PubMed, PsycInfo, EMBASE, and Web of Science were systematically searched for epidemiological studies published up to 28 October 2020. Nineteen studies, totaling 604,257 participants, met our inclusion criteria. Random-effects models were used for prevalence rates and odds ratios (OR) of mental disorders, and study quality was rated. A prevalence rate of 30% [95% CI (23.36, 37.36)] for any mental disorder in adults with a child welfare care history was found (3–17% for specific disorders). A prevalence rate of 45% [95% CI (42.38, 47.38)] for any mental disorder was found in adults with a juvenile justice care history (6–66% for specific disorders). For out-of-home placement history, adult mental disorders were significantly higher than in the general population (OR = 1.33–2.76). Studies differed in terms of methodology and the disorder groups considered, so heterogeneity between effect sizes ranged from low to high. Our findings suggest that the high risk that mental health issues will persist in adults with an out-of-home placement history needs to be taken seriously in the transition from adolescence to adulthood. The care systems involved need to collaborate and to be aware of these risks.
Coronary artery bypass grafting under sole Impella 5.0 support for patients with severely depressed left ventricular function
Authors: Katahira Shintaro , Sugimura Yukiharu , Mehdiani Arash , Assmann Alexander , Rellecke Philipp , Tudorache Igor , Boeken Udo , Aubin Hug , Lichtenberg Artur , Akhyari Payam 
Published: June 2021

AbstractSelection of the ideal surgical procedure for coronary revascularization in patients with severe cardiac dysfunction at times may represent a challenge. In recent years, with the advent of surgical large microaxial pumps, e.g., Impella 5.0 (Abiomed Inc., Boston, USA), specific support and effective unloading of the left ventricle has become available. In the interventional field, good results have been achieved with smaller microaxial pumps in the setting of so-called protected percutaneous coronary intervention. In this study, we would like to share our early experience with surgical coronary revascularization under the sole support of Impella 5.0, omitting the use of heart–lung machine in three cases of severe cardiac dysfunction due to complex ischemic heart disease. Effective circulatory support intraoperatively and postoperatively speaks in favor of this technique in selected patients.
Creation and provision of a question and answer resource for esophageal cancer based on medical professionals’ reports of patients’ and families’ views and preferences
Authors: Toh Yasushi , Inoue Yoji , Hayakawa Masayo , Yamaki Chikako , Takeuchi Hiroya , Ohira Masaichi , Matsubara Hisahiro , Doki Yuichiro , Wakao Fumihiko , Takayama Tomoko 
Published: June 2021

AbstractBackgroundIn the rapidly-progressing healthcare environment, it is essential to improve treatment quality through continuous clarification of the needs and concerns of esophageal cancer patients and their families. Effective collaboration between information providers and academic associations could help make such clarified information available.MethodsWe analyzed esophageal cancer patients’ views and preferences (PVPs) using data that were previously obtained from medical staff in Japan. Based on these PVPs, we created a question and answer (Q&A) resource through collaboration with the Cancer Information Service in Japan (CISJ) and the Japan Esophageal Society (JES).ResultsRegarding esophageal cancer, “diet and eating behavior” was the most frequent PVP mentioned by patients and their families, followed by “treatment-related symptoms and adverse effects” and “daily life, recuperation, and survivorship.” These PVPs were noted by a wide variety of medical specialties. By analyzing the PVPs, the CISJ developed 11 proposed questions and sent them to the JES, which then created answers based on evidence and clinical–practice-associated consensus. The resultant Q&A resource was uploaded to the CISJ website with mutual linkage to the JES website.ConclusionsThis study showed the usefulness of collecting esophageal–cancer-related PVPs from medical staff and fostering successful collaboration between a cancer-information provider and an academic association. This arrangement may represent a model case for developing a sustainable system that can satisfactorily respond to PVPs regarding other cancers and/or issues.
Multi-modality assessment and role of left atrial function as an imaging biomarker in cardiovascular disease
Authors: Alfuhied Aseel , Kanagala Prathap , McCann Gerry P. , Singh Anvesha 
Published: June 2021

AbstractThe left atrium (LA) plays a vital role in maintaining normal cardiac function. LA volume and function have been utilised as important imaging biomarkers, with their prognostic value demonstrated in multiple cardiac conditions. More recently, there has been a sharp increase in the number of publications utilising LA strain by echocardiography and cardiac magnetic resonance (CMR) imaging. However, little is known about its prognostic value or reproducibility as a technique. In this review, we aim to highlight the conventional and novel imaging techniques available for LA assessment, using echocardiography and CMR, their role as an imaging biomarker in cardiovascular disease, the reproducibility of the techniques and the current limitations to their clinical application. We identify a need for further standardisation of techniques, with establishment of ‘normal’ cut-offs before routine clinical application can be made.
Biorefining: the role of endoglucanases in refining of cellulose fibers
Authors: Nagl Martin , Haske-Cornelius Oskar , Skopek Lukas , Pellis Alessandro , Bauer Wolfgang , Nyanhongo Gibson Stephen , Guebitz Georg 
Published: June 2021

AbstractWith an annual production of more than 400 million tons, paper is the main product of the largest biorefinery process industrially implemented. Enzymes have been used for pulp refining to dramatically reduce energy consumption. However, exact mechanisms related to the individual enzymes are hardly understood. Yet, this knowledge would be important to predict enzyme performance in industrial processes. Three commercial refining enzyme formulations showed different endoglucanase (1.25 nkat mg−1–13.7 nkat mg−1), β-glucosidase (0.57 nkat mg−1–1.34 nkat mg−1) and xylanase activities (1.78 nkat ml−1–62.1 nkat mg−1) on model substrates. Additionally, distinct amounts of reducing sugars from hardwood sulfate pulp were released. Endoglucases were purified from each formulation by using hydrophobic interaction and anion exchange chromatography and showed molecular weights from 20 to 55 kDa and specific activities ranging between 3.11 and 26.3 nkat mg−1according to endoglucanase specific derivatized cellopentaose (CellG5). Refining trials of hardwood sulfate pulp were conducted using a PFI laboratory mill and fiber properties such as degree of refining or fiber length and properties of formed sheets like tensile index were monitored. Thereby, enzymes were dosed based on identical endoglucanase activity on CellG5. Enzyme formulations and purified endoglucanases led to an increase of the degree of refining of up to 47.9 [°SR] at 6000 PFI revolutions while the tensile index was improved by up to 76.0 Nm g−1. In summary, refining effects can be primarily attributed to endoglucanases indicating activity on CellG5 being a suitable parameter for enzyme dosing.
The Role of Social Skills in Predicting Treatment-Recovery in Children with a Social Anxiety Disorder
Authors: Klein Anke M. , Liber Juliette M. , van Lang Natasja D. J. , Reichart Catrien , Nauta Maaike , van Widenfelt Brigit M. , Utens Elisabeth M. W. J. 
Published: June 2021

AbstractThe current study investigated the role of social skills and its interaction with social anxiety as predictors of treatment outcome in children with an anxiety disorder either with or without a social anxiety disorder (SoAD). In total, 133 children (aged 8 to 13) with an anxiety disorder received a 10-session cognitive behavioral treatment (FRIENDS program). Pre- to post treatment Reliable Change (RC) and Treatment-Recovery (TR) were assessed from a multi-informant perspective, by including diagnostic information (ADIS C/P), child-reported anxiety symptoms (MASC) and parent-reported internalizing symptoms (CBCL-Int). Social skills were assessed with the parent-rated Social Skills Rating System (assertion, self-control, responsibility). Results showed that 1) parents of children with a SoAD reported significantly less favorable use of assertive and responsible social behavior in their children pre-treatment than parents of children without SoAD, 2) children with higher social skills had a better treatment recovery, and 3) children with anxiety and higher responsible behavior pre-treatment and without a SoAD had a better treatment recovery, but this effect did not show for children with SoAD. In conclusion, better use of social behavior increased the likelihood of treatment recovery but not of reliable change. Further studies on the role of social skills in the treatment of childhood (social) anxiety are needed to investigate the mechanisms by which social skills impact treatment outcome.
Methodological Signatures in Early Ethology: The Problem of Animal Subjectivity
Authors: Klassen Anna 
Published: June 2021

AbstractWhat is the adequate terminology to talk about animal behaviour? Is terminology referring to mental or emotional states anthropomorphic and should therefore be prohibited or is it a necessary means to provide for an adequate description and should be encouraged? This question was vehemently discussed in the founding phase of Ethology as a scientific discipline and still is. This multi-layered problem can be grasped by using the concept of methodological signatures, developed by Köchy et al. (2016c). It is designed to analyse and systematically compare animal research approaches by examining their common parameters. By examining the works of Konrad Lorenz (1903–1989) and Nikolaas Tinbergen (1907–1988), this paper offers new insights both on a methodological and theoretical level. Methodologically, the application of the concept of methodological signatures is illustrated; theoretically, the principles of Classic Ethology are analysed. My aim is to illustrate how the problem of scientific access to animal subjectivity was addressed in the history of Ethology by analysing statements about animal sentience. For this purpose, I will first outline the general discussion about animal subjectivity and the tension between anthropomorphism and empirical adequacy. I introduce my own theoretical and methodological framework before presenting an analysis of Lorenz’ and Tinbergen’s methodological signatures. Thereby, I show how the question of terminology is deeply embedded in a network of epistemological, methodological and ontological concepts and establish key characteristics in regard to ethological approaches to animal subjectivity. Finally, I shed light on the possibility of using this typology to examine current frameworks of animal welfare research.
Rank-Adaptive Tensor Methods for High-Dimensional Nonlinear PDEs
Authors: Dektor Alec , Rodgers Abram , Venturi Daniele 
Published: June 2021

AbstractWe present a new rank-adaptive tensor method to compute the numerical solution of high-dimensional nonlinear PDEs. The method combines functional tensor train (FTT) series expansions, operator splitting time integration, and a new rank-adaptive algorithm based on a thresholding criterion that limits the component of the PDE velocity vector normal to the FTT tensor manifold. This yields a scheme that can add or remove tensor modes adaptively from the PDE solution as time integration proceeds. The new method is designed to improve computational efficiency, accuracy and robustness in numerical integration of high-dimensional problems. In particular, it overcomes well-known computational challenges associated with dynamic tensor integration, including low-rank modeling errors and the need to invert covariance matrices of tensor cores at each time step. Numerical applications are presented and discussed for linear and nonlinear advection problems in two dimensions, and for a four-dimensional Fokker–Planck equation.
Advanced analysis of oligomeric proanthocyanidins: latest approaches in liquid chromatography and mass spectrometry based analysis
Authors: Symma Nico , Hensel Andreas 
Published: June 2021

AbstractProanthocyanidins (PAC) are an important and widely spread class of natural products with various bioactivities. The analytical evaluation of oligomeric and polymeric proanthocyanidins in complex extracts is still challenging, due to the complexity of structures. Nevertheless, in the last 20 years analytical techniques especially in the field of chromatography and mass spectrometry have been improved and offer exciting possibilities for a deeper insight into plant secondary metabolism. While classical colorimetric methods and protocols for partial hydrolysis are still valuable tools new chromatographically and mass spectrometric methods provide deep insights into the PAC fine structure, also of polymeric material. The present review focus on recent innovative LC–MS and MALDI-TOF methods, innovative strategies for advanced processing of LC-HRMS data (van Krevelen plots, Kendrick Mass Defect Analysis), MS/MS fragmentation, and newest two-dimensional LC × LC (Offline, Online, Stop-flow-2D) chromatography. Also MALDI-TOF imaging provides exciting inside in PAC distribution within biological samples and functional assays.
Effects of school-based mindfulness intervention on health-related quality of life: moderating effect of gender, grade, and independent practice in cluster randomized controlled trial
Authors: Lassander Maarit , Hintsanen Mirka , Suominen Sakari , Mullola Sari , Vahlberg Tero , Volanen Salla-Maarit 
Published: June 2021

Abstract
Object
We investigated the impact of a school-based 9-week mindfulness program vs. active control program (relaxation) and inactive control group on children’s self-reported Health-Related Quality of Life (HRQoL) moderated by gender, grade, and independent practice.

Method
In total 3519 (50/50% boys/girls) Finnish students aged 12–15 years from 56 schools were randomized into mindfulness intervention, active, and inactive control groups. HRQoL was measured at baseline, at 9 weeks, and at 26 weeks and analyzed with multilevel linear modeling.

Results
Significant improvement on HRQoL was found (β = mean difference) (β = 1.587, 95% CI 0.672–2.502, p < 0.001) after 9 weeks and at 26 weeks of follow-up among students in the mindfulness group as compared to the active control group. Moderating effects on HRQoL were found for gender, grade, and independent practice: girls, 7th and 8th grade students, and students with regular independent mindfulness practice benefited most.

Conclusions
Gender and developmental stage may moderate the effects of mindfulness interventions on HRQoL and offer guidance in designing effective promotive interventions for children and adolescents.

Trial Registration Information
Healthy Learning Mind—a school-based mindfulness and relaxation program: a study protocol for a cluster randomized controlled trial (RCT) ISRCTN18642659 retrospectively registered on 13 October 2015. The full trial protocol can be accessed at http://rdcu.be/t57S.
Do main paths reflect technological trajectories? Applying main path analysis to the semiconductor manufacturing industry
Authors: Filippin Flavia 
Published: June 2021

AbstractIt has been proposed that main path analysis can be used to identify technological trajectories in patent-citation networks. In this paper, the method is applied to a network composed of one million US patents and eight million citations in order to trace the backbone of the technological trajectory of the semiconductor manufacturing industry. An in depth discussion of the method is presented, focusing on the many parameters that can be adjusted while applying it and on the consequences of adjusting any of them. Moreover, and differently from other papers on the subject, the result of the algorithm is analysed to determine if it indeed represents the most important technological contributions to the trajectory or if it is merely a collection of relevant and connected patents. This is made easier by the fact that the semiconductor industry has a clear and widely known technological trajectory that spans more than 50 years, Moore's law.