bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gallium triggered crystallization of spinel glass-ceramic and enhancement in colorization and luminescence
Authors: Xu Xiaoyun , Wang Zhiwen , Chen Simin 
Published: August 2021

Abstract
Spinel glass–ceramic is an important class of composites with promising applications in transparent antiriot shields, tunable lasers and broadband optical amplifiers. Although the crystallization process of spinel has been well studied, the approach for tuning it and the optical response of the resultant glass–ceramic still need urgent attention. Here, we posit that the addition of Ga2O3 can significantly improve the crystallization tendency of the spinel phase and greatly change the optical response of the glass–ceramic. On one hand, the colourization of glass–ceramic can be tuned, and an unusual blue colour can be achieved. On the other hand, the luminescence can be notably enhanced, and the resultant spinel glass–ceramic exhibits intense green–yellow luminescence. The present findings about the Ga2O3–mediated structure modification and optical response tuning can provide an effective avenue for the functionalization of spinel glass–ceramic and may be general for various types of material candidates.
Accuracy of the independent atom approximation in digital tomosynthesis Monte Carlo simulations
Authors: Primidis Thomas G , Soloviev Vadim Y , Welsch Carsten P 
Published: August 2021

Abstract
Monte Carlo (MC) codes serve as the gold standard simulation tool during design and optimisation of x-ray imaging systems. Such simulations often model Rayleigh scattering based on the Independent Atom Approximation Model (IAM). This model neglects the low range molecular interference (MI) effects of non-crystalline materials such as human tissues. Previous work has found discrepancies in the simulated images of planar x-ray images between IAM and MI models. However, insignificant differences were found for computed tomography (CT) reconstructions. In this work we present Geant4 MC simulations of a flat panel source digital tomosynthesis (DT) system for human extremities. Results show that with a 1:9 scatter to primary ratio (SPR) in the x-ray projections, the DT reconstructions are insensitive to the differences of the IAM and MI models. Therefore, MC codes that use the IAM model are sufficient for the study of DT systems. That is because DT algorithms have a larger effect on image quality than the few percent change in the noise due to a physical model and noise suppression methods make this change even less important. Dependency of this conclusion on SPR must be considered in other DT modalities where SPR might be larger.
Reduction, reorganization and stasis in the evolution of turtle shell elements
Authors: Cordero Gerardo A , Vlachos Evangelos 
Published: August 2021

Abstract
Novel phenotypic configurations can profoundly alter the evolutionary trajectories of species. Although innovation can precede lengthy periods of evolutionary stasis, the potential for species to diversify further can be realized via modular changes across distinct levels of hierarchical organization. To test this expectation, we undertook anatomical network analyses to model the organization and composition of the turtle’s shell. Our results suggest that stem turtles featured the greatest diversity in the number of skeletal (bones) and epidermal (scutes) shell elements. The shell subsequently underwent numerical simplification. Thus, the sum of potential connections (links) in shell networks has diminished in modern turtles. Some network system descriptors of complexity, integration and modularity covaried with the number of network components (nodes), which has remained evolutionarily stable since the Jurassic. We also demonstrated that shell reorganization might be feasible within modular subdivisions, particularly in modern turtles with simplified and less integrated network structures. We discuss how these findings align with previous studies on numerical simplification with enhanced skeletal specialization in the tetrapod skull. Altogether, our analyses expose the evolvability of the turtle’s shell and bolster the foundation for further macroevolutionary comparisons of ancient and modern species.
Assessing chromatin relocalization in 3D using the patient rule induction method
Authors: Segal Mark R 
Published: August 2021

Summary
Three-dimensional (3D) genome architecture is critical for numerous cellular processes, including transcription, while certain conformation-driven structural alterations are frequently oncogenic. Inferring 3D chromatin configurations has been advanced by the emergence of chromatin conformation capture assays, notably Hi-C, and attendant 3D reconstruction algorithms. These have enhanced understanding of chromatin spatial organization and afforded numerous downstream biological insights. Until recently, comparisons of 3D reconstructions between conditions and/or cell types were limited to prescribed structural features. However, multiMDS, a pioneering approach developed by Rieber and Mahony (2019). that performs joint reconstruction and alignment, enables quantification of all locus-specific differences between paired Hi-C data sets. By subsequently mapping these differences to the linear (1D) genome the identification of relocalization regions is facilitated through the use of peak calling in conjunction with continuous wavelet transformation. Here, we seek to refine this approach by performing the search for significant relocalization regions in terms of the 3D structures themselves, thereby retaining the benefits of 3D reconstruction and avoiding limitations associated with the 1D perspective. The search for (extreme) relocalization regions is conducted using the patient rule induction method (PRIM). Considerations surrounding orienting structures with respect to compartmental and principal component axes are discussed, as are approaches to inference and reconstruction accuracy assessment. The illustration makes recourse to comparisons between four different cell types.
Old, New, Borrowed and Blue – Shifts In Modern Policing
Authors: Dahl Johanne Yttri , Fyfe Nicholas R , Gundhus Helene Oppen Ingebrigtsen , Larsson Paul , Skjevrak Pernille Erichsen , Runhovde Siv Rebekka , Vestby Annette 
Published: August 2021

AbstractThis article analyses ambiguity and complexity in proactive policing practices and identifies the paradox that despite the focus on increasing proactivity, police work remains strongly reactive. Drawing on a set of Norwegian case studies of policing in different domains, the article shows how under an overarching objective of ‘combating crime’, the distinctions between non-coercive (mainly proactive) forms of prevention or (mainly reactive) methods such as investigation or intelligence are seen as unimportant. This creates a demand for professionals working across different crime types, leading to a shift towards high policing in everyday life and tension between experts and generalists. Other, unintended consequences include a fragmentation of tasks and a more general and abstract way of policing. The result is pluralization and multiagency partnership strategies, where the police conduct high-policing tasks and external actors conduct low-policing tasks. These findings point to the emergence of new forms of hybrid of policing.
Network Analysis of Human Brain Connectivity Reveals Neural Fingerprints of a Compositionality Bias in Signaling Systems
Authors: Lumaca Massimo , Vuust Peter , Baggio Giosuè 
Published: August 2021

AbstractCompositionality is a hallmark of human language and other symbolic systems: a finite set of meaningful elements can be systematically combined to convey an open-ended array of ideas. Compositionality is not uniformly distributed over expressions in a language or over individuals’ communicative behavior: at both levels, variation is observed. Here, we investigate the neural bases of interindividual variability by probing the relationship between intrinsic characteristics of brain networks and compositional behavior. We first collected functional resting-state and diffusion magnetic resonance imaging data from a large participant sample (N = 51). Subsequently, participants took part in two signaling games. They were instructed to learn and reproduce an auditory symbolic system of signals (tone sequences) associated with affective meanings (human faces expressing emotions). Signal-meaning mappings were artificial and had to be learned via repeated signaling interactions. We identified a temporoparietal network in which connection length was related to the degree of compositionality introduced in a signaling system by each player. Graph-theoretic analysis of resting-state functional connectivity revealed that, within that network, compositional behavior was associated with integration measures in 2 semantic hubs: the left posterior cingulate cortex and the left angular gyrus. Our findings link individual variability in compositional biases to variation in the anatomy of semantic networks and in the functional topology of their constituent units.
Improvements in Severe Acute Respiratory Syndrome Coronavirus 2 Testing Cascade in the United States: Data From Serial Cross-sectional Assessments
Authors: Clipman Steven J , Wesolowski Amy , Mehta Shruti H , Cobey Sarah , Cummings Derek A T , Solomon Sunil S 
Published: August 2021

Abstract

Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing is critical for monitoring case counts, early detection and containment of infection, clinical management, and surveillance of variants. However, community-based data on the access, uptake, and barriers to testing have been lacking.

Methods
We conducted serial cross-sectional online surveys covering demographics, coronavirus disease 2019 symptoms, and experiences around SARS-CoV-2 diagnostic testing to characterize the SARS-CoV-2 testing cascade and associated barriers across 10 US states (California, Florida, Illinois, Maryland, Massachusetts, Nebraska, North Dakota, South Dakota, Texas, and Wisconsin), from July 2020 to February 2021.

Results
In February 2021, across 10 US states, 895 respondents (11%) reported wanting a diagnostic test in the prior 2 weeks, 63% of whom were tested, with limited variability across states. Almost all (97%) who were tested received their results; 56% received their results within 2 days. In Maryland, Florida, and Illinois, where serial data were available at 4 time points, 56% were tested the same day they wanted or needed a test in February 2021, compared with 28% in July 2020, and 45% received results the same day, compared with 17% in July 2020. Wanting a test was significantly more common among younger, nonwhite respondents and participants with a history of symptoms or exposure. Logistical challenges, including not knowing where to go, were the most frequently cited barriers.

Conclusions
There were significant improvements in access and turnaround times across US states, yet barriers to testing remained consistent across states, underscoring the importance of a continued focus on testing, even amidst mass vaccination campaigns.
Southern States in International Development Cooperation: From Contestation to Norm Conception
Authors: Duarte Rubens de S , Milani Carlos R S 
Published: August 2021

Abstract
Why and how do Southern countries conceive norms in the field of international aid and cooperation in an attempt to craft a symbolic regime that challenges Northern-oriented development agendas? To answer this question, this article engages with the literature on the life cycle of norms and goes beyond the earlier concepts of cascade, localisation, subsidiarity, reluctance, rejection, and contestation. As it considers the international–domestic nexus as the main catalyst for norm conception, this paper contributes to the existing literature on norm circulation by providing a more nuanced and context-led analysis of Southern countries’ normative role. In building upon the dialectics between international and domestic politics, this paper refutes the simple norm-taker/norm-maker dyad wherein the former is regarded as the South’s only possible role. Written from a Southern perspective, this paper also explores a range of channels, mechanisms, and platforms that Southern actors mobilise to create and diffuse their development cooperation norms both regionally and globally.
Do boars compensate for hunting with higher reproductive hormones?
Authors: Davidson Achiad , Malkinson Dan , Schonblum Anat , Koren Lee , Shanas Uri 
Published: August 2021

AbstractThe predation-stress hypothesis has been proposed as a general mechanism to explain the negative effect of predation risk on reproduction, through a chronic activation of the stress response. However, in some cases, stress appears to augment the reproductive potential of mammals. Wild boar (Sus scrofa) populations are on a rise worldwide, despite the high hunting pressure that they are exposed to. This hunting pressure instigates, among other effects, earlier sexual maturity in juvenile females, leading to the shortening of wild boars’ generation time. The mechanism that underlies this earlier sexual maturity under high hunting pressure has not been examined to date. To explore the physiological effects that hunting has on the reproductive system and whether the stress response is involved, we examined steroid hormone levels in the hair of female wild boars in northern Israel, comparing populations exposed to high and low hunting pressure. Furthermore, we compared steroid levels in the hair of female wild boars that were roaming alone or as a part of a group. We found no hormonal signs of stress in the hunted boars. Cortisol levels were low in both the high and low hunting-pressure groups. Yet, progesterone levels were higher in females that were exposed to high hunting pressure. Females roaming in a group also had higher progesterone levels compared to females that were alone, with no distinguishable differences in cortisol levels. These elevations in reproductive hormones that were associated with hunting may lead to a higher reproductive potential in female wild boars. They further show that high hunting pressure does not necessarily lead to chronic stress that impairs the reproductive potential of female wild boars. This data suggests that a reproductive hormonal response may be one of the factors leading to the rapid wild boars population growth worldwide, despite the high hunting pressure.
Biomarkers of reproduction in endangered green sea turtles (Chelonia mydas) nesting at Tortuguero, Costa Rica
Authors: Bruno Renato Saragoça , Restrepo Machado Jaime Alberto , Guzman Gilberto Rafael Borges , Loria Jorge Iván Ramos , Valverde Roldán Arturo 
Published: August 2021

Abstract
Understanding the timing of vitellogenesis is essential for identifying threats to the reproductive success of endangered oviparous vertebrate species, such as sea turtles. We measured concentrations of testosterone (T) and vitellogenin (VTG) in green sea turtles (Chelonia mydas) nesting at Tortuguero, Costa Rica, as biomarkers of ovarian development. Testosterone concentration increased from the first to second month and VTG concentration increased at the third week of sampling. These results show that Tortuguero green sea turtles were still producing both biomarkers early into the nesting season. VTG concentration was negatively correlated with female weight, suggesting that larger females start nesting earlier at Tortuguero and that we may have sampled larger females further into their reproductive cycle.
Advancing urban ethnopharmacology: a modern concept of sustainability, conservation and cross-cultural adaptations of medicinal plant lore in the urban environment
Authors: Dutta Tusheema , Anand Uttpal , Saha Suchismita Chatterjee , Mane Abhijit Bhagwan , Prasanth Dorairaj Arvind , Kandimalla Ramesh , Proćków Jarosław , Dey Abhijit 
Published: August 2021

AbstractThe discipline ‘urban ethnopharmacology’ emerged as a collection of traditional knowledge, ancient civilizations, history and folklore being circulated since generations, usage of botanical products, palaeobotany and agronomy. Non-traditional botanical knowledge increases the availability of healthcare and other essential products to the underprivileged masses. Intercultural medicine essentially involves ‘practices in healthcare that bridge indigenous medicine and western medicine, where both are considered as complementary’. A unique aspect of urban ethnopharmacology is its pluricultural character. Plant medicine blossomed due to intercultural interactions and has its roots in major anthropological events of the past. Unani medicine was developed by Khalif Harun Al Rashid and Khalif Al Mansur by translating Greek and Sanskrit works. Similarly, Indo-Aryan migration led to the development of Vedic culture, which product is Ayurveda. Greek medicine reached its summit when it travelled to Egypt. In the past few decades, ethnobotanical field studies proliferated, especially in the developed countries to cope with the increasing demands of population expansion. At the same time, sacred groves continued to be an important method of conservation across several cultures even in the urban aspect. Lack of scientific research, validating the efficiency, messy applications, biopiracy and slower results are the main constrains to limit its acceptability. Access to resources and benefit sharing may be considered as a potential solution. Indigenous communities can copyright their traditional formulations and then can collaborate with companies, who have to provide the original inventors with a fair share of the profits since a significant portion of the health economy is generated by herbal medicine. Search string included the terms ‘Urban’ + ‘Ethnopharmacology’, which was searched in Google Scholar to retrieve the relevant literature. The present review aims to critically analyse the global concept of urban ethnopharmacology with the inherent plurality of the cross-cultural adaptations of medicinal plant use by urban people across the world.
Red, yellow, or green? Do consumers’ choices of food products depend on the label design?
Authors: Carlsson Fredrik , Kataria Mitesh , Lampi Elina , Nyberg Erik , Sterner Thomas 
Published: August 2021

Abstract
Using a stated preference survey, we investigate to what extent consumers are willing to make costlier food consumption choices to decrease damages to health, the environment, and animal well-being. In particular, we investigate how the graphic design of the labels affects choice behaviour by comparing traffic–light and greyscale labels and plain-text description with each other. We found that the red colour in traffic lights seems to strengthen respondents’ preferences for avoiding the worst level of a collective attribute such as climate impact or antibiotics use, while the green colour strengthened preferences for the more private attribute, namely healthiness. On average, the price premiums for a green label compared with a red label is 52 per cent for healthiness, 64 per cent for both animal welfare and antibiotics, and 20 per cent for climate impact.
HypoSVI: Hypocentre inversion with Stein variational inference and physics informed neural networks
Authors: Smith Jonthan D , Ross Zachary E , Azizzadenesheli Kamyar , Muir Jack B 
Published: August 2021

SUMMARY
We introduce a scheme for probabilistic hypocentre inversion with Stein variational inference. Our approach uses a differentiable forward model in the form of a physics informed neural network, which we train to solve the Eikonal equation. This allows for rapid approximation of the posterior by iteratively optimizing a collection of particles against a kernelized Stein discrepancy. We show that the method is well-equipped to handle highly multimodal posterior distributions, which are common in hypocentral inverse problems. A suite of experiments is performed to examine the influence of the various hyperparameters. Once trained, the method is valid for any seismic network geometry within the study area without the need to build traveltime tables. We show that the computational demands scale efficiently with the number of differential times, making it ideal for large-N sensing technologies like Distributed Acoustic Sensing. The techniques outlined in this manuscript have considerable implications beyond just ray tracing procedures, with the work flow applicable to other fields with computationally expensive inversion procedures such as full waveform inversion.
Identification and characterization of O-linked glycans in cervical mucus as biomarkers of sperm transport: A novel sheep model
Authors: Abril-Parreño Laura , Wilkinson Hayden , Krogenæs Anette , Morgan Jack , Gallagher Mary E , Reid Colm , Druart Xavier , Fair Sean , Saldova Radka 
Published: August 2021

Abstract
Cervical mucus plays an important role in female fertility, since it allows the entry of motile and morphological normal sperm while preventing the ascent of pathogens from the vagina. The function of cervical mucus is critically linked to its rheological properties that are in turn dictated by O-glycosylated proteins, called mucins. We aimed to characterize the O-glycan composition in the cervical mucus of six European ewe breeds with known differences in pregnancy rates following cervical/vaginal artificial insemination with frozen–thawed semen, which are due to reported differences in cervical sperm transport. These were Suffolk (low fertility) and Belclare (medium fertility) in Ireland, Ile de France and Romanov (both with medium fertility) in France, and Norwegian White Sheep (NWS) and Fur (both with high fertility) in Norway (n = 28–30 ewes/breed). We identified 124 O-glycans, from which 51 were the major glycans with core 2 and fucosylated glycans as the most common structures. The use of exogenous hormones for synchronization did not affect the O-glycan composition in both high-fertility ewe breeds, but it did in the other four ewe breeds. There was a higher abundance of the sulfated glycan (Galβ1–3[SO3-GlcNAcβ1–6]GalNAc), fucosylated glycan (GlcNAcβ1–3(Fucα1–2Galβ1–3)GalNAc) and core 4 glycan (GlcNAcβ1–3[GlcNAcβ1–6]GalNAc) in the low-fertility Suffolk breed compared with NWS (high fertility). In addition, core 4 glycans were negatively correlated with mucus viscosity. This novel study has identified O-glycans that are important for cervical sperm transport and could have applications across a range of species including human.
Intestinal immunity: to be, or not to be, induced? That is the question
Authors: Takahashi Daisuke , Kimura Shunsuke , Hase Koji 
Published: August 2021

Abstract
The intestinal immune system maintains intestinal homeostasis in collaboration with diverse immune cell subsets residing at the epithelial layer, lamina propria and gut-associated lymphoid tissue (GALT). Bacterial components and their metabolites are essential for the establishment of the gut immune system. In addition, nutritional signals contribute to maintaining the mucosal immune response. Specialized epithelial microfold (M) cells in GALT facilitate immune surveillance on the mucosal surface by actively taking up external antigens to transport them into the lymphoid follicles. Because hyperplasia of M cells causes an excessive immune response in GALT, there is a self-regulatory mechanism to control the development of M cells appropriately. In this review, we will discuss the molecular mechanisms of mucosal immune regulation and their biological importance.