bluuebunny/crossref_metadata_2025_split huggingface dataset:
The General Factor of Personality (GFP) and Vocational Interests: a Test of Social Effectiveness at the Behavioral and Genetic Level
Authors: van der Linden Dimitri , Dunkel Curtis S. , De Zeeuw Eveline J. , Wu Peiqian , Pelt Dirk H. M. 
Published: November 2021

AbstractPrevious studies have examined how personality models (e.g., Big Five, HEXACO) relate to vocational interests. We adopt a novel approach by testing the associations between personality and vocational interests from the perspective of the general factor of personality (GFP). One interpretation of the GFP is that it reflects social effectiveness. Based on this interpretation, we predicted that the GFP is particularly related to interest in social jobs because people generally tend to be attracted to activities in which they perform well. To test this, we used four large data sets: the Professional Worker Career Experience Survey (study 1a; N = 752), OpenPsychometrics.org (study 1b, N = 108,209), Project Talent (study 2; N = 81,130), and the National Merit Twin Study (study 3: N = 1536 in 768 twin pairs). In each sample, we presented the direct associations as well as the results after using control variables (gender and cognitive ability). In study 1a and 1b, the GFP particularly related to interest in social and enterprising occupations. In study 2, the GFP related to interest in working with people and was also associated with a range of occupational scales involving social aspects. In study 3, the GFP only showed a consistent relation with social interests. This association was present at the phenotypical as well as genetic level. Notwithstanding some variation in findings across the different studies, the overall pattern seems to be in line with the notion that the GFP is positively associated with the preference for more socially laden jobs.
Law of demand and stochastic choice
Authors: Cerreia-Vioglio S. , Maccheroni F. , Marinacci M. , Rustichini A. 
Published: November 2021

AbstractWe consider random choice rules that, by satisfying a weak form of Luce’s choice axiom, embody a form probabilistic rationality. We show that for this important class of stochastic choices, the law of demand for normal goods—arguably the main result of traditional consumer theory—continues to hold on average when strictly dominated alternatives are dismissed.
Point detection through multi-instance deep heatmap regression for sutures in endoscopy
Authors: Sharan Lalith , Romano Gabriele , Brand Julian , Kelm Halvar , Karck Matthias , De Simone Raffaele , Engelhardt Sandy 
Published: November 2021

Abstract
Purpose:
Mitral valve repair is a complex minimally invasive surgery of the heart valve. In this context, suture detection from endoscopic images is a highly relevant task that provides quantitative information to analyse suturing patterns, assess prosthetic configurations and produce augmented reality visualisations. Facial or anatomical landmark detection tasks typically contain a fixed number of landmarks, and use regression or fixed heatmap-based approaches to localize the landmarks. However in endoscopy, there are a varying number of sutures in every image, and the sutures may occur at any location in the annulus, as they are not semantically unique.

Method:
In this work, we formulate the suture detection task as a multi-instance deep heatmap regression problem, to identify entry and exit points of sutures. We extend our previous work, and introduce the novel use of a 2D Gaussian layer followed by a differentiable 2D spatial Soft-Argmax layer to function as a local non-maximum suppression.

Results:
We present extensive experiments with multiple heatmap distribution functions and two variants of the proposed model. In the intra-operative domain, Variant 1 showed a mean $$F_1$$

F
1

of $$+ 0.0422$$

+
0.0422

over the baseline. Similarly, in the simulator domain, Variant 1 showed a mean $$F_1$$

F
1

of $$+ 0.0865$$

+
0.0865

over the baseline.

Conclusion:
The proposed model shows an improvement over the baseline in the intra-operative and the simulator domains. The data is made publicly available within the scope of the MICCAI AdaptOR2021 Challenge https://adaptor2021.github.io/, and the code at https://github.com/Cardio-AI/suture-detection-pytorch/.
Adhesion Behavior of Ti–PMMA–Ti Sandwiches for Biomedical Applications
Authors: Nayak Gargi Shankar , Mouillard Flavien , Masson Patrick , Pourroy Geneviève , Palkowski Heinz , Carradò Adele 
Published: November 2021

AbstractThe “stress-shielding” problem, common with metallic implants, may be solved by using biocompatible sandwiches with a polymeric core between two metallic skin sheets. To achieve such sandwiches, a process route has been developed, beginning with the grafting of poly-(methyl-methacrylate) (PMMA) on titanium (Ti) sheets via the “grafting from” technique. Grafting resulted in variable thicknesses of PMMA on the Ti sheets. Hot-pressing was used to prepare semi-finished Ti–PMMA–Ti sandwiches. The adhesion was achieved by the interpenetration between PMMA sheet and the grafted PMMA chains. Investigation was carried out to understand the influence of the grafted PMMA thickness on the adhesion strength. Similar adhesion strengths were found for the sandwiches despite variable grafted PMMA thicknesses, indicating a successful grafting of PMMA on large-scale Ti sheets. The adhesion followed the autohesion theory, where a time-dependent increase in adhesion strength was found for the sandwiches.
Four new threatened species of Rinorea (Violaceae), treelets from the forests of Cameroon
Authors: Achoundong Gaston , van der Burgt Xander , Cheek Martin 
Published: November 2021

SummaryFour species of Rinorea are described as new to science; all four species are endemic to evergreen rain forest in Cameroon. Rinorea villiersii Achound. and R. amietii Achound are placed in Rinorea [unranked] Crassiflorae M.Brandt, while, R. dewildei Achound. and R. faurei Achound. fall in Rinorea [unranked] Dentatae Engl. The first species appears to be endemic to the Solé Forest Reserve northeast of Yabassi in Littoral Region. The second and the third species are found mainly in Littoral and South Regions, R. amietii extending to South West Region and R. dewildei extending to Central Region. The fourth species, R. faurei is an endemic of the Santchou Forest Reserve at the foot of Dschang Plateau in West Region. The taxonomic affinities of the four species are discussed, illustrations and a distribution map are provided, and their conservation status is assessed. All four species are threatened with extinction according to the 2012 IUCN categories and criteria.
Specificity of Entorhinal Atrophy MRI Scale in Predicting Alzheimer’s Disease Conversion
Authors: Roberge Xavier , Brisson Mélanie , Laforce Robert Jr. 
Published: November 2021

AbstractWe compared entorhinal cortex atrophy (ERICA) score vs. medial temporal atrophy (MTA) score’s ability to predict conversion from amnestic mild cognitive impairment (aMCI) to Alzheimer’s disease (AD) using magnetic resonance imaging (MRI). We hypothesized that ERICA would show higher specificity. Data from 61 aMCI patients were analyzed. Positive ERICA was associated with AD conversion with a sensitivity of 56% (95% CI: 30–80%) and a specificity of 78% (63–89%) vs. 69% (41–89%) SE and 60% (44–74%) SP for the MTA. Results suggest that ERICA is superior to MTA in predicting conversion from aMCI to AD in a small sample of participants.
Late-night noise hazards and the Tokyo Metropolitan Government's countermeasures in the 1960s
Authors: Hasegawa Junichi 
Published: November 2021

AbstractIn 1960s Tokyo, late-night noise became a source of annoyance for urban-dwellers in residential areas. The problem was primarily due to young people who congregated around small food establishments eating and drinking. The situation led to the Tokyo Metropolitan Government to attempt to remove such small businesses through the 1969 Environmental Pollution Prevention Ordinance. However, the section of the ordinance dealing with late-night noise hazards was diluted by the political parties, who supported the interests of such businesses, hence failing to satisfy local residents who were victims of the problem.
Language history on fast forward: Innovations in heritage languages and diachronic change
Authors: Kupisch Tanja , Polinsky Maria 
Published: November 2021

AbstractThere has been a substantial amount of research on heritage language acquisition and diachronic change. Although recent work has increasingly pointed to parallels between those two areas, it remains unclear how systematic these are. In this paper, we provide a bird's eye view, illustrating how patterns of diachronic change are mirrored in heritage language grammars. In doing so, we focus on one of the best-described grammaticalization processes – namely, the formation of articles from demonstratives and numerals, reviewing studies on heritage varieties which mirror those processes. Based on this review, we make two main points: that change in heritage language can be predicted based on established diachronic scenarios, and that heritage languages often amplify incipient changes in the baseline. After discussing a number of attested changes in a bilingual context, we identify directions for future research in the domain of determiners in heritage languages.
Atom Probe Study of the Miscibility Gap in CuNi Thin Films and Microstructure Development
Authors: Duran Rüya , Stender Patrick , Eich Sebastian Manuel , Schmitz Guido 
Published: November 2021

Abstract
The unclear miscibility of CuNi alloys was investigated with atom probe tomography (APT). Multilayered thin film samples were prepared by ion beam sputtering (IBS) and focused ion beam (FIB) shaping. Long-term isothermal annealing treatments in a UHV furnace were conducted at temperatures of 573, 623, and 673 K to investigate the mixing process. The effective interdiffusion coefficient of the nanocrystalline microstructure (including defect diffusion) was determined to be Deff = 1.86 × 10−10 m2/s × exp(−164 kJ/mol/RT) by fitting periodic composition profiles through a Fourier series. In nonequilibrium states, microstructural defects like grain boundaries and precipitates were observed. While at the two higher temperatures total mixing is observed, a clear experimental evidence is found for a miscibility gap at 573 K with the boundary concentrations of 26 and 66 at%. These two compositions are used in a subregular solution model to reconstruct the phase miscibility gap. So, the critical temperature TC of the miscibility gap is found to be 608 K at a concentration of 45 at% Ni.
Global event-based surveillance of chemical incidents
Authors: Gaulton Tom , Hague Charlotte , Cole David , Thomas Eirian , Duarte-Davidson Raquel 
Published: November 2021

Abstract
Background
The number of chemicals in our society and in our daily lives continues to increase. Accompanying this is an increasing risk of human exposure to and injury from hazardous substances. Performing regular, structured surveillance of chemical incidents allows a greater awareness of the types of chemical hazards causing injury and the frequency of their occurrence, as well as providing a better understanding of exposures.

Objective
The objective of performing event-based surveillance (EBS) and capturing chemical incidents is to use this information to increase the situational awareness of chemical incidents, improve the management of these incidents and to inform measures to protect public health.

Methods
This paper describes a method for EBS for chemical incidents, including the sources used, storing the gathered information and subsequent analysis of potential trends in the data.

Results
We describe trends in the type of incidents that have been detected, the chemicals involved in these incidents and the health effects caused, in different geographic regions of the world.

Significance
The methodology presented here provides a rapid and simple means of identifying chemical incidents that can be set up rapidly and with minimal cost, the outputs of which can be used to identify emerging risks and inform preparedness planning, response and training for chemical incidents.
Long-term results and GvHD after prophylactic and preemptive donor lymphocyte infusion after allogeneic stem cell transplantation for acute leukemia
Authors: Schmid Christoph , Labopin Myriam , Schaap Nicolaas , Veelken Hendrik , Brecht Arne , Stadler Michael , Finke Juergen , Baron Frederic , Collin Matthew , Bug Gesine , Ljungman Per , Blaise Didier , Tischer Johanna , Bloor Adrian , Kulagin Aleksander , Giebel Sebastian , Gorin Norbert-Claude , Esteve Jordi , Ciceri Fabio , Savani Bipin , Nagler Arnon , Mohty Mohamad 
Published: November 2021

AbstractWe report on 318 patients with acute leukemia, receiving donor lymphocyte infusion (DLI) in complete hematologic remission (CHR) after allogeneic stem cell transplantation (alloSCT). DLI were applied preemptively (preDLI) for minimal residual disease (MRD, n = 23) or mixed chimerism (MC, n = 169), or as prophylaxis in high-risk patients with complete chimerism and molecular remission (proDLI, n = 126). Median interval from alloSCT to DLI1 was 176 days, median follow-up was 7.0 years. Five-year cumulative relapse incidence (CRI), non-relapse mortality (NRM), leukemia-free and overall survival (LFS/OS) of the entire cohort were 29.1%, 12.7%, 58.2%, and 64.3%. Cumulative incidences of acute graft-versus-host disease (aGvHD) grade II–IV°/chronic GvHD were 11.9%/31%. Nineteen patients (6%) died from DLI-induced GvHD. Age ≥60 years (p = 0.046), advanced stage at transplantation (p = 0.003), shorter interval from transplantation (p = 0.018), and prior aGvHD ≥II° (p = 0.036) were risk factors for DLI-induced GvHD. GvHD did not influence CRI, but was associated with NRM and lower LFS/OS. Efficacy of preDLI was demonstrated by decreasing MRD/increasing blood counts in 71%, and increasing chimerism in 70%. Five-year OS after preDLI for MRD/MC was 51%/68% among responders, and 37% among non-responders. The study describes response and outcome of DLI in CHR and helps to identify candidates without increased risk of severe GvHD.
Advantages of multi-arm non-randomised sequentially allocated cohort designs for Phase II oncology trials
Authors: Mossop Helen , Grayling Michael J. , Gallagher Ferdia A. , Welsh Sarah J. , Stewart Grant D. , Wason James M. S. 
Published: November 2021

Abstract
Background
Efficient trial designs are required to prioritise promising drugs within Phase II trials. Adaptive designs are examples of such designs, but their efficiency is reduced if there is a delay in assessing patient responses to treatment.

Methods
Motivated by the WIRE trial in renal cell carcinoma (NCT03741426), we compare three trial approaches to testing multiple treatment arms: (1) single-arm trials in sequence with interim analyses; (2) a parallel multi-arm multi-stage trial and (3) the design used in WIRE, which we call the Multi-Arm Sequential Trial with Efficient Recruitment (MASTER) design. The MASTER design recruits patients to one arm at a time, pausing recruitment to an arm when it has recruited the required number for an interim analysis. We conduct a simulation study to compare how long the three different trial designs take to evaluate a number of new treatment arms.

Results
The parallel multi-arm multi-stage and the MASTER design are much more efficient than separate trials. The MASTER design provides extra efficiency when there is endpoint delay, or recruitment is very quick.

Conclusions
We recommend the MASTER design as an efficient way of testing multiple promising cancer treatments in non-comparative Phase II trials.
Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial
Authors: Forde Patrick M. , Anagnostou Valsamo , Sun Zhuoxin , Dahlberg Suzanne E. , Kindler Hedy L. , Niknafs Noushin , Purcell Thomas , Santana-Davila Rafael , Dudek Arkadiusz Z. , Borghaei Hossein , Lanis Mara , Belcaid Zineb , Smith Kellie N. , Balan Archana , White James R. , Cherry Christopher , Ashok Sivakumar I. K. , Shao Xiaoshan M. , Chan Hok Yee , Singh Dipika , Thapa Sampriti , Illei Peter B. , Pardoll Drew M. , Karchin Rachel , Velculescu Victor E. , Brahmer Julie R. , Ramalingam Suresh S. 
Published: November 2021

AbstractMesothelioma is a rare and fatal cancer with limited therapeutic options until the recent approval of combination immune checkpoint blockade. Here we report the results of the phase 2 PrE0505 trial (NCT02899195) of the anti-PD-L1 antibody durvalumab plus platinum-pemetrexed chemotherapy for 55 patients with previously untreated, unresectable pleural mesothelioma. The primary endpoint was overall survival compared to historical control with cisplatin and pemetrexed chemotherapy; secondary and exploratory endpoints included safety, progression-free survival and biomarkers of response. The combination of durvalumab with chemotherapy met the pre-specified primary endpoint, reaching a median survival of 20.4 months versus 12.1 months with historical control. Treatment-emergent adverse events were consistent with known side effects of chemotherapy, and all adverse events due to immunotherapy were grade 2 or lower. Integrated genomic and immune cell repertoire analyses revealed that a higher immunogenic mutation burden coupled with a more diverse T cell repertoire was linked to favorable clinical outcome. Structural genome-wide analyses showed a higher degree of genomic instability in responding tumors of epithelioid histology. Patients with germline alterations in cancer predisposing genes, especially those involved in DNA repair, were more likely to achieve long-term survival. Our findings indicate that concurrent durvalumab with platinum-based chemotherapy has promising clinical activity and that responses are driven by the complex genomic background of malignant pleural mesothelioma.
Discussion on effect of material on UV reflection and its disinfection with focus on Japanese Stucco for interior wall
Authors: Endo Tomonori , Gemma Aki , Mitsuyoshi Ryoto , Kodama Hiroki , Asaka Daiya , Kono Midori , Mochizuki Takeshi , Kojima Hiromi , Iwamoto Takeo , Saito Saburo 
Published: November 2021

AbstractResearch has previously shown that ultraviolet light C (UV-C) can inactivate unexpected infection. However, this type of potential disinfection is dramatically reduced for the shadow area such as under desk or medical equipment. Because the UV-C reflectance ratio is low on the general wall surfaces. We compared Stucco against the other materials to investigate whether we could improve disinfection for the shadow area. The reflectance ratios of UV-C irradiation of each material were examined, with particular attention to the rates for the author’s Modified Stucco. To evaluate the disinfection effects of the UV-C reflective lighting, colonies of E. coli and of Staphylococcus hominis were cultured in an agar media and counted over a certain time period after applying UV-C irradiation from a sterilizing lamp onto the investigation materials. The author’s Modified Stucco, produced reflectance ratios that was 11 times that of white wallpaper. This demonstrated that the UV-C reflected on the Stucco wall having optimum components and their compositions inhibited the number of E. coli and S. hominis, resulting in significantly disinfection effects on white wallpapers. The space with Modified Stucco and then irradiated by a UV-C may give a strong disinfection effect.
Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvant
Authors: Akache Bassel , Renner Tyler M. , Tran Anh , Deschatelets Lise , Dudani Renu , Harrison Blair A. , Duque Diana , Haukenfrers Julie , Rossotti Martin A. , Gaudreault Francis , Hemraz Usha D. , Lam Edmond , Régnier Sophie , Chen Wangxue , Gervais Christian , Stuible Matthew , Krishnan Lakshmi , Durocher Yves , McCluskie Michael J. 
Published: November 2021

AbstractThe huge worldwide demand for vaccines targeting SARS-CoV-2 has necessitated the continued development of novel improved formulations capable of reducing the burden of the COVID-19 pandemic. Herein, we evaluated novel protein subunit vaccine formulations containing a resistin-trimerized spike antigen, SmT1. When combined with sulfated lactosyl archaeol (SLA) archaeosome adjuvant, formulations induced robust antigen-specific humoral and cellular immune responses in mice. Antibodies had strong neutralizing activity, preventing viral spike binding and viral infection. In addition, the formulations were highly efficacious in a hamster challenge model reducing viral load and body weight loss even after a single vaccination. The antigen-specific antibodies generated by our vaccine formulations had stronger neutralizing activity than human convalescent plasma, neutralizing the spike proteins of the B.1.1.7 and B.1.351 variants of concern. As such, our SmT1 antigen along with SLA archaeosome adjuvant comprise a promising platform for the development of efficacious protein subunit vaccine formulations for SARS-CoV-2.
Synergistic effect between the KCNQ1 haplotype and alcohol consumption on the development of type 2 diabetes mellitus in Korean cohorts
Authors: Park Ji Young , Yoo Min-Gyu , Yun Ji Ho , Lee Hye-Ja , Park Sang Ick 
Published: November 2021

AbstractPotassium voltage-gated channel subfamily Q member 1 (KCNQ1) is one of the strongest susceptibility genes for type 2 diabetes mellitus (T2DM). Association studies between KCNQ1 genetic variants and T2DM have been reported. The multifactorial disease T2DM is caused by interactions between genetic susceptibility and environmental factors. In this study, we examined the associations between the KCNQ1 haplotype, which consists of the major alleles rs3852528, rs11024175, and rs2237892 (ht: ACC), and environmental factors such as alcohol consumption, which are related to the risk of T2DM, in two independent Korean populations. Data from health examination studies, i.e., HEXA (n = 50,357 subjects) and the Ansung–Ansan community-based Korean cohort study (n = 7603), were analyzed. In both cohorts, fasting blood glucose levels were significantly increased in moderate-to-heavy drinkers and carriers of the homozygous ACC haplotype. A significant association between the KCNQ1 haplotype and alcohol consumption in the risk of diabetes was observed in the HEXA (OR 1.587; 95% CI 1.128–2.234) and Ansung–Ansan (OR 2.165; 95% CI 1.175–3.989) cohorts compared with abstainers not carrying the KCNQ1 haplotype. Associations of the KCNQ1 haplotype with alcohol consumption and β-cell function were observed in the Ansung–Ansan cohort. Moderate-to-heavy drinkers with the ACC haplotype had lower fasting insulin levels and mean 60 min insulinogenic index (IGI60) compared with light drinkers and abstainers not carrying the ACC haplotype. These findings indicate that KCNQ1 variants play a synergistic role with alcohol consumption in the development of T2DM and impaired β-cell function.