bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification and characteristics of combined agrometeorological disasters caused by low temperature in a rice growing region in Liaoning Province, China
Authors: Ji Ruipeng , Yu Wenying , Feng Rui , Wu Jinwen , Zhang Yushu 
Published: May 2021

AbstractOwing to climate change, agrometeorological disasters are becoming increasingly complex. Here, we analysed the characteristics of combined agrometeorological disaster (CAD) caused by low temperature in annual rice crops in Liaoning Province, China, from 1961 to 2017. We assessed the repeat occurrence of natural disasters on rice production. The results showed that (1) there were six possible CAD scenarios in a rice growing season. These included two scenarios with one disaster in two periods (OD-1, OD-2), three scenarios with two different disasters (TD-1, TD-2, TD-3) and one with multiple disasters (MD-1). Since 1961, the overall occurrence of the six CAD scenarios showed a downward trend. Among the six scenarios, TD-1 had the greatest distribution and occurred most frequently; (2) three possible single agrometeorological disaster (SAD) scenarios may occur during a rice growing season, delayed cold damage (SAD-d), frost damage at only one stage (SAD-f), sterile-type cold damage at one stage (SAD-s). Since 1961, the SAD-d frequency decreased, whereas, since the mid-1980s, the SAD-f frequency increased; (3) SAD and CAD frequencies showed downward trends, with CAD declining more than SAD. The CAD geographical range and frequency were smaller than those of SAD. Rice damage in SAD-f and OD-1 scenarios showed no significant trend, but appeared to have slightly increased. The main agrometeorological disasters affecting rice production in Liaoning Province were delayed cold damage, frost damage or both; (4) a comparison of the rice yield reduction rates of years in which CAD or SAD occurred in more than 50% of stations in Liaoning Province revealed that the yield reduction rates associated with the former were greater than those associated with the latter. CAD had more types, and the occurrences and impacts were more complicated, than for SAD. Compared with SAD, the effects of CAD may be magnified in rice crops, leading to reduced yields.
Maternal ingestion of cocoa causes constriction of fetal ductus arteriosus in rats
Authors: Zielinsky Paulo , Martignoni Felipe Villa , Markoski Melissa , Zucatti Kelly Pozzer , dos Santos Marinho Gabriela , Pozzobon Gabriela , Magno Pedro Rafael , de Bittencourt Antunes Victória , Sulis Natassia Miranda , Cardoso Alexandra , Mattos Daniel , Naujorks Alexandre Antônio , von Frankenberg Anize Delfino , Vian Izabele 
Published: May 2021

AbstractMaternal consumption of polyphenol-rich foods has been associated with fetal ductus arteriosus constriction (DAC), but safety of chocolate exposure in fetal life has not been studied. This experimental study tested the hypothesis that maternal cocoa consumption in late pregnancy causes fetal DAC, with possible associated antioxidant effects. Pregnant Wistar rats, at the 21st gestational day, received by orogastric tube cocoa (720 mg/Kg) for 12 h, indomethacin (10 mg/Kg), for 8 h, or only water, before cesaren section. Immediately after withdrawal, every thorax was obtained and tissues were fixed and stained for histological analysis. The ratio of the narrowest part of the pulmonary artery to the fetal ductus inner diameter and increased ductal inner wall thickness characterized ductal constriction. Substances reactive to thiobarbituric acid were quantified. Statistical analysis used ANOVA and Tukey test. Cocoa (n = 33) and indomethacin (n = 7) reduced fetal internal ductus diameter when compared to control (water, n = 25) (p < 0.001) and cocoa alone increased ductus wall thickness (p < 0.001), but no change was noted in enzymes activity. This pharmacological study shows supporting evidences that there is a cause and effect relationship between maternal consumption of cocoa and fetal ductus arteriosus constriction. Habitual widespread use of chocolate during gestation could account for undetected ductus constriction and its potentially severe consequences, such as perinatal pulmonary hypertension, cardiac failure and even death. For this reason, dietary guidance in late pregnancy to avoid high chocolate intake, to prevent fetal ductal constriction, may represent the main translational aspect of this study.
Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder
Authors: Cathomas Flurin , Guetter Karoline , Seifritz Erich , Klaus Federica , Kaiser Stefan 
Published: May 2021

AbstractTryptophan and its catabolites (TRYCATs) have been suggested to link peripheral immune system activation and central neurotransmitter abnormalities with relevance to the etio-pathophysiology of schizophrenia (SZ) and major depressive disorder (MDD). The relationship to different psychopathological dimensions within these disorders however remains to be elucidated. We thus investigated potential group differences of tryptophan, kynurenine, kynurenic acid, 3-hydroxy kynurenine and quinolinic acid in the plasma of 19 healthy controls (HC), 45 patients with SZ and 43 patients with MDD and correlated plasma proteins with the “motivation and pleasure” dimension and cognition. After correcting for the covariates age, sex, body mass index, smoking and medication, patients with MDD showed lower kynurenine and 3-hydroxy kynurenine levels compared to HC. Quinolinic acid correlated negatively with composite cognitive score in patients with SZ, indicating that more severe cognitive impairments were associated with increased plasma levels of quinolinic acid. No correlations were found in patients with MDD. These results indicate that MDD and SZ are associated with dysregulation of the kynurenine pathway. Quinolinic acid might be specifically implicated in the pathophysiology of cognitive deficits in patients with SZ. Further studies are needed to determine whether TRYCATs are causally involved in the etiology of these neuropsychiatric disorders.
Detection of intracellular monosodium urate crystals in gout synovial fluid using optical diffraction tomography
Authors: Park Sangwoo , Lee Lucy Eunju , Kim Hanna , Kim Ji Eun , Lee Seung Jun , Yoon Sunggyu , Shin Seungwoo , Kang Heemin , Park YongKeun , Song Jason Jungsik , Lee Seongsoo 
Published: May 2021

AbstractOptical diffraction tomography (ODT) enables imaging of unlabeled intracellular components by measuring the three-dimensional (3D) refractive index (RI). We aimed to detect intracellular monosodium urate (MSU) crystals in synovial leukocytes derived from gout patients using ODT. The 3D RI values of the synthetic MSU crystals, measured by ODT, ranged between 1.383 and 1.440. After adding synthetic MSU crystals to a macrophage, RI tomograms were reconstructed using ODT, and the reconstructed RI tomograms discerned intracellular and extracellular MSU crystals. We observed unlabeled synthetic MSU crystal entry into the cytoplasm of a macrophage through time-lapse imaging. Furthermore, using gout patient-derived synovial leukocytes, we successfully obtained RI tomogram images of intracellular MSU crystals. The 3D RI identification of MSU crystals was verified with birefringence through polarization-sensitive ODT measurements. Together, our results provide evidence that this novel ODT can identify birefringent MSU crystals in synovial leukocytes of patients with gout.
Age and gender differences in objective sleep properties using large-scale body acceleration data in a Japanese population
Authors: Li Li , Nakamura Toru , Hayano Junichiro , Yamamoto Yoshiharu 
Published: May 2021

AbstractUsing large-scale objective sleep data derived from body acceleration signals of 68,604 Japanese residents ranging from adolescents to the elderly (10–89 years old), we found significant age- and gender-related differences in sleep properties (timing, duration, and quality) in real-life settings. Time-in-bed and total sleep time (TST) showed a U-shaped association with age, indicating their decrease in adulthood following their increase in the elderly. There was a remarkable shift in sleep phase toward earlier bedtime and earlier wake time with increasing age (> 20 years), together with worsening of sleep quality, which is estimated by sleep efficiency (SE) and wake time after sleep onset. Gender comparisons showed that TST was shorter in women than in similarly aged men, which is much evident after the age of 30 years. This was associated with later bedtimes and greater age-related deterioration of sleep quality in women. Compared to men in the same age group, women over age 50 demonstrated a greater reduction in SE with aging, due mainly to increasing durations of nighttime awakening. These differences can be attributed to several intricately intertwined causes, including biological aging as well as socio-cultural and socio-familial factors in Japan. In conclusion, our findings provide valuable insights on the characteristics of Japanese sleep habits.
Impact of multiple-scale circulation interactions on the spring diurnal precipitation over Luzon
Authors: Lee Cheng-An , Huang Wan-Ru , Chang Ya-Hui , Huang Shih-Ming 
Published: May 2021

AbstractThis study examines the spatiotemporal characteristics of diurnal precipitation over Luzon and the nearby oceans in boreal spring. The study focuses on exploring the impact of the interaction between large- and local-scale circulation changes on the modulation of diurnal precipitation. We analyze the satellite precipitation data obtained from the Tropical Rainfall Measuring Mission and Global Precipitation Measurement Mission during the spring (March–May) of 2001–2019. The results show that the spring diurnal precipitation over Luzon and the nearby oceans consists of a clear eastward propagation signal. The direction of this propagation is opposite to that of the prevailing low-level easterly wind in spring and differs from the well-known westward propagation direction of diurnal precipitation over Luzon in summer. Diagnoses of the possible maintenance mechanisms suggest that the eastward propagation diurnal precipitation can be attributed to the interaction between the topography and multiple-scale circulation changes, including the mountain–valley breeze, island-scale land–sea breeze (LSB), large-scale LSB-like circulation, and mid-to-upper-level prevailing wind fields. This finding highlights the importance of considering multiple-scale circulation changes in the modulation of spring diurnal precipitation over the East Asia–western North Pacific region.
Decreased grey matter volumes in unaffected mothers of individuals with autism spectrum disorder reflect the broader autism endophenotype
Authors: An Kyung-min , Ikeda Takashi , Hirosawa Tetsu , Yaoi Ken , Yoshimura Yuko , Hasegawa Chiaki , Tanaka Sanae , Saito Daisuke N. , Kikuchi Mitsuru 
Published: May 2021

AbstractAutism spectrum disorder (ASD) is a neurodevelopmental disorder with an early onset and a strong genetic origin. Unaffected relatives may present similar but subthreshold characteristics of ASD. This broader autism phenotype is especially prevalent in the parents of individuals with ASD, suggesting that it has heritable factors. Although previous studies have demonstrated brain morphometry differences in ASD, they are poorly understood in parents of individuals with ASD. Here, we estimated grey matter volume in 45 mothers of children with ASD (mASD) and 46 age-, sex-, and handedness-matched controls using whole-brain voxel-based morphometry analysis. The mASD group had smaller grey matter volume in the right middle temporal gyrus, temporoparietal junction, cerebellum, and parahippocampal gyrus compared with the control group. Furthermore, we analysed the correlations of these brain volumes with ASD behavioural characteristics using autism spectrum quotient (AQ) and systemizing quotient (SQ) scores, which measure general autistic traits and the drive to systemize. Smaller volumes in the middle temporal gyrus and temporoparietal junction correlated with higher SQ scores, and smaller volumes in the cerebellum and parahippocampal gyrus correlated with higher AQ scores. Our findings suggest that atypical grey matter volumes in mASD may represent one of the neurostructural endophenotypes of ASD.
Theoretical analysis on thermal treatment of skin with repetitive pulses
Authors: Ma Jingxuan , Yang Xianfeng , Sun Yuxin , Yang Jialing 
Published: May 2021

AbstractThermal ablation is an efficient method of medical treatment, such as cancer therapy, wound closure, laser cutting, freckle removal and other treatments. In order to guarantee the curative effect and the safety of the patients, the thermal response of the tissue which is subjected to the heat source need to be carefully monitored. However, it is too difficult to achieve real-time monitoring on the full-field temperature. In the present study, efforts were made to build up a theoretical model for the prediction of the thermal response in the human skin. The Dual-Phase-Lag (DPL) bio-heat transfer model and the Henrique’s burn assessment model were employed to describe the interaction of multi-pulse heat source and the skin. The repeated multi-pulse laser is a common heat source in the thermal treatment and the thermal responses of the skin would be complicated under the common effects of the non-Fourier effects and the multi-pulse source. The Green’s function approach was used to solve the governing equations analytically. The closed-form solution for the temperature distribution of the skin was obtained and the thermal damage was estimated based on the temperature results. The influences of the biological parameters (the phase lags of the heat flux and the temperature gradient) and the heat source parameters (the pulse number and the duty ratio) on the temperature distribution, the burn degree and the irreversible burn depth of the irradiated region were discussed.
Profilin2 regulates actin rod assembly in neuronal cells
Authors: Walter Lisa Marie , Rademacher Sebastian , Pich Andreas , Claus Peter 
Published: May 2021

AbstractNuclear and cytoplasmic actin-cofilin rods are formed transiently under stress conditions to reduce actin filament turnover and ATP hydrolysis. The persistence of these structures has been implicated in disease pathology of several neurological disorders. Recently, the presence of actin rods has been discovered in Spinal Muscular Atrophy (SMA), a neurodegenerative disease affecting predominantly motoneurons leading to muscle weakness and atrophy. This finding underlined the importance of dysregulated actin dynamics in motoneuron loss in SMA. In this study, we characterized actin rods formed in a SMA cell culture model analyzing their composition by LC–MS-based proteomics. Besides actin and cofilin, we identified proteins involved in processes such as ubiquitination, translation or protein folding to be bound to actin rods. This suggests their sequestration to actin rods, thus impairing important cellular functions. Moreover, we showed the involvement of the cytoskeletal protein profilin2 and its upstream effectors RhoA/ROCK in actin rod assembly in SMA. These findings implicate that the formation of actin rods exerts detrimental effects on motoneuron homeostasis by affecting actin dynamics and disturbing essential cellular pathways.
Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil
Authors: Gesto João Silveira Moledo , Ribeiro Gabriel Sylvestre , Rocha Marcele Neves , Dias Fernando Braga Stehling , Peixoto Julia , Carvalho Fabiano Duarte , Pereira Thiago Nunes , Moreira Luciano Andrade 
Published: May 2021

AbstractField release of Wolbachia-infected Aedes aegypti has emerged as a promising solution to manage the transmission of dengue, Zika and chikungunya in endemic areas across the globe. Through an efficient self-dispersing mechanism, and the ability to induce virus-blocking properties, Wolbachia offers an unmatched potential to gradually modify wild Ae. aegypti populations turning them unsuitable disease vectors. Here we describe a proof-of-concept field trial carried out in a small community of Niterói, greater Rio de Janeiro, Brazil. Following the release of Wolbachia-infected eggs, we report here a successful invasion and long-term establishment of the bacterium across the territory, as denoted by stable high-infection indexes (> 80%). We have also demonstrated that refractoriness to dengue and Zika viruses, either thorough oral-feeding or intra-thoracic saliva challenging assays, was maintained over the adaptation to the natural environment of Southeastern Brazil. These findings further support Wolbachia’s ability to invade local Ae. aegypti populations and impair disease transmission, and will pave the way for future epidemiological and economic impact assessments.
Study of microcomb threshold power with coupling scaling
Authors: Wang Pei-Hsun , Chiang Kuan-Lin , Yang Zong-Ren 
Published: May 2021

AbstractWe model the generation threshold and conversion efficiency of microcombs by scaling the cavity coupling. With the Lugiato–Lefever equation (LLE), quantitative analysis of threshold is established in the parameter space of pump power and coupling. Considering the large detuning and Kerr-induced phase shift, the threshold power is numerically solved with the minimum at over-coupling, in agreement with that from the traveling wave theory. Furthermore, the coupling dependence on microcomb generation is discussed, providing the accessibility of high-efficient, stable combs (≥ 40%) around the threshold. This work offers universal guidelines for the design of microcombs with low-power and high-efficient operation.
Comparison of anthropometric and body composition indices in the identification of metabolic risk factors
Authors: Lee Bum Ju , Yim Mi Hong 
Published: May 2021

AbstractWhether anthropometric or body composition indices are better indicators of metabolic risk remains unclear. The objectives of this study were to compare the association of metabolic risk factors with anthropometric and body composition indices and to identify the better indicators for risk factors in a large-scale Korean population. In this cross-sectional study, the associations of body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) as anthropometric indices and trunk fat mass (TFM), percent trunk fat mass (%TFM), whole-body total fat mass (WBTFM), and percent whole-body total fat mass (%WBTFM) as body composition indices with metabolic risk factors were compared by complex-samples multiple logistic regression models based on complex-sample survey data. In men, WHtR, BMI, and TFM were similarly associated with hypertension. Diabetes, hyperlipidemia, and hypo-high-density lipoprotein (HDL) cholesterolemia tended to be more strongly associated with WHtR and WC than body composition indices. Hypertriglyceridemia and hypercholesterolemia were more strongly associated with WHtR and %TFM than other indices. In women, hypertension tended to be more strongly associated with WHtR than other indices. TFM, %TFM, and WHtR were similarly associated with hyperlipidemia. Diabetes and hypo-HDL cholesterolemia were more strongly associated with WHtR and WC than body composition indices. Hypertriglyceridemia and hypercholesterolemia were more strongly associated with WHtR and %TFM than other indices. Among six metabolic risk factors, the validity and utility of the anthropometric indices in identifying risk factors tended to be similar to or better than those of the body composition indices, except for hypertension and hypercholesterolemia in men and hyperlipidemia and hypercholesterolemia in women.
Determinants of vessel defects in superficial and deep vascular layers in normal-tension glaucoma using optical coherence tomography angiography
Authors: Lee Jiyun , Park Chan Kee , Park Hae-Young Lopilly 
Published: May 2021

AbstractWe investigated the characteristics of localized vessel density defects (VD) either in the deep or superficial vascular layer of normal-tension glaucoma patients using optical coherence tomography angiography (OCTA). In this retrospective, cross-sectional study, 74 eyes with localized retinal nerve fiber layer (RNFL) defect were included. The relationships between the widths of the VD in the superficial and deep layer and ocular factors were evaluated. Eyes with greater deep VD were significantly older (P = 0.023). The IOP measured at OCTA exam was significantly related to the width of the deep VD (P = 0.009). By contrast, average ganglion cell inner plexiform layer thickness (GCIPLT) was substantially related to the width of the superficial VD (P = 0.004). In logistic regression analysis, aging was noticeably associated with wider deep VD, whereas worse mean deviation (MD) had a significant association with wider superficial VD (P = 0.001, P = 0.003, respectively). In sum, while changes of the superficial layer seemed an overall ramification of glaucomatous damages, the deep layer was more likely to be affected by factors related to ocular microcirculation, such as IOPs and older age. Thus, looking into the deep vascular layer using OCTA could identify risk factors related to the disturbance in ocular microcirculation.
Dynamic analysis of peripheral blood TCR β-chain CDR3 repertoire in occupational medicamentosa-like dermatitis due to trichloroethylene
Authors: Lin Dafeng , Wang Dianpeng , Li Peimao , Yang Xiangli , Liu Wei , Huang Lu , Zhang Zhimin , Zhang Yanfang , Zhang Wen , Zhang Naixing , Zhang Ming , Huang Xianqing 
Published: May 2021

AbstractPreviously, we had cross-sectionally explored the characteristics of T cell receptor (TCR) repertoires from occupational medicamentosa-like dermatitis due to trichloroethylene (OMDT) patients, now we further analyzed the dynamic features of OMDT TCR repertoires. Peripheral blood TCR β-chain complementarity-determining region 3 (CDR3) genes were detected with the high throughput sequencing in 24 OMDT cases in their acute, chronic and recovery stages, respectively, and in 24 trichloroethylene-exposed healthy controls. The TCR repertoire diversity, TRBV/TRBD/TRBJ gene usage and combination, frequencies of CDR3 nucleotide (nt) and amino acid (aa) sequences in the cases in different stages and in the controls were analyzed. TRBV6-4 and TRBV7-9 frequencies significantly differed between the cases and controls (both P < 6.1 × 10–4). TRBV6-4 combination with TRBJ2-1, TRBJ2-2, TRBJ2-3, and TRBJ2-6, and TRBV7-9 combination with TRBJ2-1 were associated with the stage by OMDT severity (all P < 0.001). Ten CDR3-nt and 7 CDR3-aa sequences in TRBV7-9-TRBJ2-1 combination and 1 CDR3-nt and 1 CDR3-aa sequences in TRBV6-4-TRBJ2-1 combination were identified as associated with the severity of OMDT (all P < 0.001). We revealed further how TCR repertoires vary with the severity in the development of OMDT, and severity-related TCRs may provide important therapeutic targets for OMDT in clinical practice.