bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gut and intraocular fluid dysbiosis in people with type 2 diabetes-related retinopathy in India: A case for further research
Authors: Das Taraprasad , Takkar Brijesh , Padakandala Shalem R , Shivaji Sisinthy 
Published: December 2024

Purpose:
To explore the relationship between gut microbiome, gut mycobiome, and intraocular (aqueous humor) microbiome dysbiosis in people with type 2 diabetes (T2DM) and diabetic retinopathy (DR).

Design:
Multiple case-control studies.

Methods:
We evaluated three groups of people: healthy controls (HC), people with T2DM without retinopathy, and those with DR. The study samples included fecal matter (30–50 g) and aqueous humor (0.05–0.1 mL). After amplicon sequencing, we analyzed microbiome profiles (V3–V4 region of bacterial 16S rRNA gene) and mycobiome (ITS2 region of fungal rRNA gene). The main outcome measures were relative abundance, α and β diversity, and dysbiotic bacteria and fungi, analyzed based on the inferred functions of the taxa.

Results:
We recruited 82 people for gut microbiome (30 HC, 24 DM, and 28 DR); 75 people for gut mycobiome (30 HC, 21 DM, and 24 DR); and 12 people for aqueous humor microbiome (4 each HC, DM, and DR) studies. Generally, there was an increased abundance of pro-inflammatory and pathogenic microorganisms and a decreased abundance of anti-inflammatory and probiotic microorganisms. The differences were higher between HC and DM/DR than between DM and DR. In aqueous humor, there was a wider separation in microbiome profiles of people with DR than their gut microbiome.

Conclusion:
The gut and aqueous humor microbiota of people with diabetes and DR may differ from those without diabetes. Given these unique observations in individuals living in one region of India, further research involving people from different regions is required to identify indices for possible regional or global use.
Rekonsiliasi dan Pengampunan
Authors: Rumbi Frans Paillin , Sulle Yosef 
Published: December 2024

Pemberontakan Darul Islam/ Tentara Islam Indonesia (DI/TII) di Sulawesi Selatan tahun 1951-1965, meninggalkan luka dalam ingatan kolektif penyintas di Seko, secara khusus umat Kristen. Ingatan atas luka turut memengaruhi rekonsiliasi di Seko. Penelitian ini bermaksud mengkaji rekonsiliasi di Seko Lemo dalam perspektif teologi pengampunan. Metode penelitian yang kami gunakan ialah pendekatan kualitatif jenis fenomenologi. Peneliti melakukan wawancara kepada penyintas (generasi pertama dan kedua). Hasil penelitian menunjukkan bahwa rekonsiliasi Kristen-Islam berlangsung sejak mereka pulang dari pengungsian. Rekonsiliasi di Seko sangat ditentukan oleh faktor kekeluargaan, perkawinan, kesediaan mendengar pengakuan dan narasi pelaku. Penyintas mengampuni berdasarkan ajaran kekristenan tentang mendoakan musuh. Akan tetapi, pengampunan yang berlangsung masih bersifat pengampunan sosial (orang per orang). Kami merekomendasikan perlunya memberi perhatian terhadap pengampunan Ilahi. Pengampunan ilahi merupakan anugerah Tuhan kepada manusia berdosa, yang harusnya mendasari pengampunan kepada sesama.
The relationship between the functional status of the extremities and “core” stabilization in women with fibromyalgia
Authors: Kuru Sinem , Basakci Calik Bilge , Gur Kabul Elif , YIGIT Murat 
Published: December 2024

IntroductionThe aim of this study was to examine the relationship between the functional status of the extre­mities and “core” stabilization in women with fibromyalgia (FM).Material and methodsFifty-seven women with FM were included. The Widespread Pain Index (WPI), Visual Analogue Scale-Pain (VAS-Pain), Symptom Severity Scale (SSS), Fibromyalgia Impact Questionnaire (FIQ), McGill Static endurance tests (trunk flexors endurance, trunk extensors endurance, lateral bridge tests), Disabilities of the Arm, Shoulder and Hand Questionnaire (DASH), grip strength, Lower Extremity Functional Scale (LEFS), chair-stand test, pressure pain threshold and 6-minute walk test (6MWT) were used in evaluation.ResultsThe trunk flexors endurance test showed a weak correlation with 6MWT (<i>r</i> = 0.392), DASH (<i>r</i> = –0.347), LEFS (<i>r</i> = 0.328) and WPI (<i>r</i> = –0.289). The trunk extensors endurance test showed a weak correlation with grip strength-right (<i>r</i> = 0.285), DASH (<i>r</i> = –0.301) and LEFS (<i>r</i> = 0.321) and a moderate correlation with grip strength-left (<i>r</i> = 0.407), chair-stand test (<i>r</i> = 0.470) and 6MWT (<i>r</i> = 0.524). The right lateral bridge test showed a weak correlation with grip strength-right (<i>r</i> = 0.271), DASH (<i>r</i> = –0.379), LEFS (<i>r</i> = 0.254), WPI (<i>r</i> = –0.306), average of maximal values of pressure pain threshold (<i>r</i> = 0.316) and average of mean values of pressure pain threshold (<i>r</i> = 0.337); it showed a moderate correlation with grip strength-left (<i>r</i> = 0.418) and 6MWT (<i>r</i> = 0.414). The left lateral bridge test showed a weak correlation with grip strength-right (<i>r</i> = 0.279), chair-stand test (<i>r</i> = 0.276), 6MWT (<i>r</i> = 0.359), DASH (<i>r</i> = –0.294), average of maximal values of pressure pain threshold (<i>r</i> = 0.315) and average of mean values of pressure pain threshold (<i>r</i> = 0.370); it showed a moderate correlation with grip strength-left (<i>r</i> = 0.502) (<i>p</i> < 0.05).ConclusionsCore muscle endurance is associated with upper and lower extremity functional level and pain parameters in women with FM.
New inflammatory markers associated with disease activity in rheumatoid arthritis: pan-immune-inflammation value, systemic immune-inflammation index, and systemic inflammation response index
Authors: Okutan İpek , Aci Recai , Keskin Âdem , Bilgin Melek , Kızılet Halit 
Published: December 2024

IntroductionThis study aimed to investigate the relationship between the pan-immune-inflammation value (PIV), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) and disease activity in rheumatoid arthritis (RA), characterized by chronic inflammation and immune system involvement, and to provide new insights into the clinical implications of RA.Material and methodsA total of 148 participants, including 97 RA patients (both newly diagnosed and established cases) and 51 healthy controls, were included in the study. Disease severity was assessed using the Disease Activity Score 28 (DAS28), and the relationship between DAS28 and PIV, SII, and SIRI, obtained from complete blood count results, was investigated. Additionally, C-reactive protein and erythrocyte sedimentation rate measurements were included in the study.ResultsThe average age of RA patients was significantly higher than that of healthy individuals (<i>p</i> = 0.002). A positive correlation was found between the DAS28 score and the inflammation indices (SII, PIV, SIRI), with 65.98% of RA patients in the active phase and 34.02% in remission. Systemic immune-inflammation index had a predictive accuracy of 75.26%, PIV 71.13%, and SIRI 72.16%. The AUC (area under curve) values for SII, PIV, and SIRI were 0.717, 0.719, and 0.717, respectively, with cutoff values of 611.45, 323.88, and 1.18. Sensitivity and specificity were calculated as 57.81% and 60.61% for SII, 60.94% and 63.64% for PIV, and 59.38% and 63.64% for SIRI.ConclusionsThe findings revealed that PIV, SII, and SIRI were elevated in individuals with RA and may serve as complementary diagnostic markers. PIV, SII, and SIRI, as measures of disease activity in RA, may help monitor treatment efficacy and improve patient prognosis.
ANALISIS TINGKAT RESIKO KESEHATAN DAN KESELAMATAN KERJA DENGAN MENGGUNAKAN METODE HIRARC DI RUMAH MAKAN X
Authors: Fais Moh. Ainul , Deviyanti I Gusti Ayu Sri , Prihartanti Wiwik , Rahmanto Agus 
Published: December 2024

ABSTRAKPenelitian ini bertujuan untuk menganalisis tingkat risiko keselamatan dan kesehatan kerja (K3) di Rumah Makan X (Ayam Kremes) menggunakan metode Hazard Identification, Risk Assessment, and Risk Control (HIRARC). Metode ini mencakup tiga tahap: identifikasi bahaya, penilaian risiko berdasarkan Likelihood dan Consequence, serta pengendalian risiko. Hasil penelitian mengidentifikasi empat potensi bahaya utama: terpeleset di lantai licin, terkena pisau, terkena uap panas, dan terkena minyak panas. Berdasarkan matriks penilaian risiko, dua bahaya masuk dalam kategori risiko ekstrim, yaitu terpeleset dan terkena minyak panas, sementara risiko terkena pisau dan uap panas berada pada tingkat risiko sedang. Untuk mengurangi risiko, direkomendasikan penggunaan alat pelindung diri (APD) dan penerapan prosedur keselamatan yang lebih ketat. Penelitian ini memberikan kontribusi penting dalam meningkatkan penerapan K3 di sektor usaha kecil seperti rumah makan.
ABSTRACT
This study aims to analyze the level of occupational safety and health (K3) risks in Restaurant X (Ayam Kremes) using the Hazard Identification, Risk Assessment, and Risk Control (HIRARC) method. This method includes three stages: hazard identification, risk assessment based on Likelihood and Consequences, and risk control. The results of the study identified four main potential hazards: slipping on slippery floors, being hit by knives, being exposed to hot steam, and being exposed to hot oil. Based on the risk assessment matrix, two hazards fall into the extreme risk category, namely slipping and being exposed to hot oil, while the risk of being exposed to knives and hot steam is at a moderate risk level. To reduce the risk, the use of personal protective equipment (PPE) and the implementation of stricter safety procedures are recommended. This research makes an important contribution in improving the implementation of K3 in the small business sector such as restaurants.
A RESERVA DO POSSÍVEL E AS ESCOLHAS TRÁGICAS NO BRASIL: UMA ANÁLISE FISCAL E TRIBUTÁRIA ANTE O CUSTEAMENTO DOS DIREITOS
Authors: Fraga Potyra Vita , Silva Thaelainy Reis da , Ferreira Júnior Adive Cardoso 
Published: December 2024

O presente artigo traz uma abordagem acerca dos custos dos direitos frente ao princípio da reserva do possível e as escolhas trágicas no Brasil. Busca-se evidenciar uma discussão ao confrontá-los ante as limitações estatais e o princípio supra, bem como discorrer as suas influências nas escolhas da Administração Pública. É manifesto que o Estado possui o dever de viabilizar os direitos e as garantias fundamentais previstos na Constituição Federal de 1988 e em leis infraconstitucionais, todavia, deve-se reunir fundos para que não sejam uma mera expectativa, o que desmitifica, em partes, o excesso de onerosidade tributária. Para tanto, a metodologia empregada foi de pesquisa bibliográfica com abordagem ualitativa, utilizando-se a técnica snowballing. Derradeiramente, o estudo expõe que a carga tributária nacional não tem seguido o princípio da capacidade contributiva para com os seus contribuintes, além disso, os direitos e as garantias permanentemente enfrentam óbices à sua efetivação. Logo, conclui-se que o agente público deve basear todas as suas escolhas por uma eminente racionalidade ética e econômica em prol da maior eficiência na utilização dos recursos.
Relationship Between Knowledge And Attitude Of Adolescent Girls With Personal Hygiene Behavior During Menstruation
Authors: Niar Niar , Sartika Sartika , M Syikir , Firna Fransiska 
Published: December 2024

Introduction: Personal hygiene is an effort in maintaining and caring for the cleanliness of all members of the body including reproductive organs. During menstruation, the blood vessels in the uterus are easily injured, therefore personal hygiene is very important to be carried out in order to be free from reproductive organ dysfunction. (Sri Ninta, 2023).
Objective: To determine the relationship between knowledge and attitude of adolescent girls with personal hygiene behavior during menstruation at Mts Fathul Amin Matakali.
Method: The type of research used is quantitative research with the research design that the author makes is an Analytical Survey using a Cross Sectional study approach. The population in this study were all adolescent girls of Mts Fathul Amin Matakali who had experienced menstruation as many as 50 female students. the sampling technique used was non probability with the type of sampling, namely total sampling. The research instrument is a questionnaire. This research questionnaire sheet consists of questions regarding knowledge, attitudes with personal hygiene behavior during menstruation which are distributed directly by researchers to respondents or by interviews between researchers and respondents. Data analysis using Chi Square analysis.
Result: There is a relationship between knowledge and personal hygiene behavior in adolescent girls at Mts Fathul Amin Matakali with a p-value = 0.004 (<0.05). There is a relationship between attitude and personal hygiene behavior in adolescent girls at Mts Fathul Amin Matakali with a p-value = 0.000 (<0.05).
Conclusion: Knowledge and attitude show that there is a relationship with personal hygiene behavior during menstruation at Mts Fathul Amin Matakali. Mts Fathul Amin Matakali can utilize print media such as posters, leaflets, or school magazines to increase the exposure of female students to information about personal hygiene during menstruation.
<span style="margin-left:0cm;text-align:justify;"><strong>Thực trạng quản lý hoạt động giáo dục kỹ năng sống cho học sinh ở các trường trung học cơ sở huyện Tháp Mười, tỉnh Đồng Tháp</strong></span>
Authors: Nguyễn Hữu Nghị 
Published: December 2024

Quản lý hoạt động giáo dục kỹ năng sống cho học sinh là rèn cho học sinh có được những hành vi lành mạnh, giúp học sinh có kinh nghiệm trong cuộc sống và hình thành ở học sinh các giá trị văn hoá con người trong thời đại hiện nay, giúp cho học sinh có nền tảng vững chắc khi chuyển qua một môi trường mới và quan hệ mới. Để có cơ sở cho nhà trường có thể đưa ra một số biện pháp nâng cao chất lượng và hiệu quả quản lý hoạt động giáo dục kỹ năng sống cho học sinh ở các trường trung học cơ sở huyện Tháp Mười, tỉnh Đồng Tháp, chúng tôi đã tiến hành khảo sát 56 ý kiến của 13 cán bộ quản lý và 43 giáo viên thông qua bảng hỏi Liket 5 mức độ về thực trạng quản lý hoạt động giáo dục kỹ năng sống cho học sinh ở các trường trung học cơ sở huyện Tháp Mười, tỉnh Đồng Tháp. Kết quả đánh giá cho thấy công tác quản lý và tổ chức triển khai hoạt động giáo dục kỹ năng sống cho học sinh ở các trường trung học cơ sở huyện Tháp Mười, tỉnh Đồng Tháp còn nhiều khó khăn và bất cập.
Leading Change: Course Choice in General Education Distribution Requirements
Authors: Andrade Maureen Snow 
Published: December 2024

ABSTRACT
General Education (GE) is a distinctive feature of U.S. higher education. Regional accreditation standards emphasize the inclusion of a GE component in degree programs, the identification of learning outcomes, and the assessment of those outcomes. Although GE reform is occurring on many campuses, the role of student choice of GE courses has received little attention. Such information has implications in terms of how many and which courses institutions offer, and for GE reform in general. Institutions make significant resource investments in their GE programs; therefore, increased understanding of course offerings, choice, and selection practices is critical. The primary purpose of this critical reflection is to examine course choice, specifically in the context of menu style GE distribution requirements. The reflection is contextualized with reference to a case study that illustrates important lessons for leading GE reform. The reflection offers a call to action not only for institutions to examine menu-style GE models and student course choice practices but for leaders to examine how to lead such reforms.
What’s the DIFference: Evaluating the Validity Claims of a General Education Program
Authors: Hunsberger Josiah , Hathcoat John D. 
Published: December 2024

ABSTRACT
General education programs often offer students a choice among various courses to fulfill a specific requirement. However, the extent to which these courses equally enable students to achieve the intended learning outcomes can vary, potentially giving some students an unintended advantage. This article evaluates whether students are inadvertently disadvantaged in meeting learning outcomes across different courses designed to fulfill a global experience requirement within a general education program. This study analyzed differential item functioning (DIF) on a university-wide assessment among a sample of 1,697 students who selected one of five distinct courses. The findings revealed that multiple items exhibited DIF, with further analysis indicating that students who chose Macroeconomics to fulfill the global perspectives requirement were particularly disadvantaged on items measuring the ability to analyze “societies different from one’s own,” while being advantaged on more quantitatively-oriented test items. These results highlight a potential misalignment between courses intended to meet the same learning outcomes and raise concerns about equitable opportunities to achieve those outcomes.
Analysis of the aetiology of acute suppurative otitis media in patients treated between 2023 and 2024
at the Military Institute of Medicine – National Research Institute, Department of Paediatrics, Nephrology
and Paediatric Allergology
Authors: Kołodziej Joanna , Pogonowska Milena , Zabielska Bernadeta , Kalicki Bolesław 
Published: December 2024

Wprowadzenie i celOstre zapalenie ucha środkowego jest jedną z najczęstszych chorób zapalnych wieku dziecięcego. Celem pracy była analiza etiologii ostrych ropnych zapaleń ucha środkowego z perforacją u pacjentów pediatrycznych, hospitalizowanych w latach 2023–2024.Materiał i metodyAnalizie retrospektywnej poddano dane pacjentów hospitalizowanych z powodu ostrego ropnego zapalenia ucha środkowego z perforacją, u których wykonano wymaz z przewodu słuchowego i posiew uzyskanego materiału.WynikiU dzieci, u których wykonano posiew ropnej wydzieliny z objętego zapaleniem ucha wyizolowano następujące patogeny: <i>Haemophilus influenzae</i>, <i>Pseudomonas aeruginosa</i>, <i>Staphylococcus aureus</i>, <i>Streptococcus pyogenes</i>, <i>Staphylococcus epidermidis</i>.WnioskiW przypadku perforacji błony bębenkowej i wycieku ropnej wydzieliny ocena posiewu z antybiogramem jest kluczowa w doborze celowanej i skutecznej antybiotykoterapii.
ECHINOCANDINS ARE A NEW CLASS OF ANTIFUNGAL AGENTS FOR THE TREATMENT OF FUNGAL INFECTIONS
Authors: AMANGELDI⃰ А.А. , SADANOV A.K. , BAIMAKHANOVA B.B. , BALGIMBAYEVA A.S. , LAKHK O.N. , ORAZYMBET S.E. , TRENOZHNIKOVA L.P. , KULMAGAMBETOV I.R. , DAURENBEKOVA Sh.Zh. , MIRALIMOVA Sh.M. 
Published: December 2024

The review article provides information on the producers, chemical nature, spectrum and mechanism of action, pharmacokinetics of echinocandins, representing a new class of antifungal compounds used in the treatment of deep human mycoses.
В обзорной статье приводятся сведения о продуцентах, химической природе, спектре и механизме действия, фармокинетике эхинокандинов, представляющих новый класс противогрибковых соединений, применяемых при лечении глубоких микозов человека.
THERMAL STABILITY OF A LIVE ATTENUATED VACCINE AGAINST INFECTIOUS BOVINE RHINOTRACHEITIS
Authors: KURMASHEVA A.K. , BULATOV Ye.A. , SAMETOVA Zh.Zh. , NAKHANOV A.K. , KYRGYZBAYEVA A.S. , KONDIBAYEVA Zh , ABITAEV R.T. , USSEMBAY A.K. , BARAKBAYEV K.B. , ZHUNUSHOV A.T. 
Published: December 2024

The stability of viruses during lyophilization and storage is important while live virus vaccines are producing. For this reason, an optimal protective medium for stabilization is added to the virus-containing material. This work examines the thermal stability of a live-attenuated vaccine against infectious bovine rhinotracheitis (IBR) with various stabilizing medium of protein-carbohydrate composition. For this purpose, the vaccine strain «R-93» of IBR virus and 5 combinations of protein-carbohydrate medium were used: 5% peptone + 3% lactose, 5% peptone + 3% sucrose, 2,5% lactalbumin hydrolysate (LAH) + 5% trehalose dihydrate, 2,5% LAH + 5% sucrose, 2,5% peptone + 2,5% sucrose. The vaccine without the addition of a protective medium served as a control. The activity of the vaccine samples after lyophilization and further storage at temperatures of plus 37℃; (20-22)℃ was studied for 7 days, and at minus -20℃ and 4℃ - for 6 months with determination of biological activity in MDBK cell culture using the Reed and Mench method. According to the research results, it was revealed that the combination of 5% peptone with 3% sucrose, 2,5% LAH with 5% trehalose dihydrate and 2,5% peptone with 2,5% sucrose turned out to be the most effective in lyophilization and storage of the vaccine against IBR.
При изготовлении живых вирус-вакцин большое значение имеет стабильность вирусов во время лиофилизации и хранения. В этой связи к вируссодержащему материалу добавляют оптимальную защитную среду для стабилизации. В данной работе рассматривается термостабильность живой аттенуированной вакцины против инфекционного ринотрахеита крупного рогатого скота (ИРТ КРС) с различными стабилизирующими средами белкового-углеводного состава. Для этого использовали вакцинный штамм «Р-93» вируса ИРТ КРС и пять комбинаций белково-углеводных сред: пептон 5% + лактоза 3%, пептон 5% + сахароза 3%, гидролизат лактальбумина (ГЛА) 2,5% + дегидрат трегалоза 5%, ГЛА 2,5% + сахароза 5%, пептон 2,5% + сахароза 2,5%, а также пробы без добавления стабилизирующей среды (контроль). Активность образцов вакцины после лиофильного высушивания и дальнейшего хранения при температурах плюс 37℃; 20-22℃ исследовали в течение семи сут, а при -20℃ и 4℃ – в течение 6 мес. с определением биологической активности в культуре клеток MDВK по методу Рида и Менча. Результаты исследования показали, что комбинация 5% пептон + 3% сахароза, 2,5% ГЛА + 5% дегидрат трегалоза и 2,5% пептон + 2,5% сахароза оказались наиболее эффективными при лиофилизации. У данных образцов вакцины при хранении в течение 3 сут. при 20-22℃, а также при 4℃ и -20℃ в течение 6 мес. не обнаружено статистически значимого снижения биологической активности вируса.
STUDY OF SAFETY AND TOLERABILITY OF THE PROBIOTIC DRUG "AS-PROBIONORM" IN HEALTHY VOLUNTEERS (PHASE I)
Authors: SEIDALINA A.B. , SADANOV A.K. , BAYMAKHANOVA B.B. , ORAZYMBET S.E. , RATNIKOVA I.A. , MASIRBAEVA A.D. , MELNIKOV V.G. 
Published: December 2024

The purpose of this study is to investigate the safety and tolerability of the domestic probiotic drug "AS-Probionorm" produced by Industrial Microbiology LLP, consisting of an association of lactic acid bacteria of targeted action, for oral use in the treatment of inflammatory and infectious diseases of the gastrointestinal tract (gastrointestinal tract) in healthy subjects. In the first phase of the clinical trial of the drug, the main attention is paid to safety and tolerability. Such a study will provide valuable information on the potential applicability of the drug in clinical practice for the prevention and treatment of intestinal infections.
Целью данного исследования является исследование безопасности и переносимости отечественного пробиотического препарата «АС-Пробионорм» производства ТОО «Промышленная микробиология», состоящего из ассоциации молочнокислых бактерий целевого действия, для перорального применения в лечении воспалительных и инфекционных заболеваний желудочно-кишечного тракта (ЖКТ) у здоровых субъектов. В I фазе клинического исследования препарата основное внимание уделяется безопасности и переносимости. Такое исследование даст ценную информацию о потенциальной применимости препарата в клинической практике для профилактики и лечения кишечных инфекций.