bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of PD-L1 tumor positive score in lung squamous cell carcinoma with H&E staining images and deep learning
Authors: Wang Qiushi , Deng Xixiang , Huang Pan , Ma Qiang , Zhao Lianhua , Feng Yangyang , Wang Yiying , Zhao Yuan , Chen Yan , Zhong Peng , He Peng , Ma Mingrui , Feng Peng , Xiao Hualiang 
Published: December 2024

BackgroundDetecting programmed death ligand 1 (PD-L1) expression based on immunohistochemical (IHC) staining is an important guide for the treatment of lung cancer with immune checkpoint inhibitors. However, this method has problems such as high staining costs, tumor heterogeneity, and subjective differences among pathologists. Therefore, the application of deep learning models to segment and quantitatively predict PD-L1 expression in digital sections of Hematoxylin and eosin (H&amp;E) stained lung squamous cell carcinoma is of great significance.MethodsWe constructed a dataset comprising H&amp;E-stained digital sections of lung squamous cell carcinoma and used a Transformer Unet (TransUnet) deep learning network with an encoder-decoder design to segment PD-L1 negative and positive regions and quantitatively predict the tumor cell positive score (TPS).ResultsThe results showed that the dice similarity coefficient (DSC) and intersection overunion (IoU) of deep learning for PD-L1 expression segmentation of H&amp;E-stained digital slides of lung squamous cell carcinoma were 80 and 72%, respectively, which were better than the other seven cutting-edge segmentation models. The root mean square error (RMSE) of quantitative prediction TPS was 26.8, and the intra-group correlation coefficients with the gold standard was 0.92 (95% CI: 0.90–0.93), which was better than the consistency between the results of five pathologists and the gold standard.ConclusionThe deep learning model is capable of segmenting and quantitatively predicting PD-L1 expression in H&amp;E-stained digital sections of lung squamous cell carcinoma, which has significant implications for the application and guidance of immune checkpoint inhibitor treatments. And the link to the code is https://github.com/Baron-Huang/PD-L1-prediction-via-HE-image.
Feeding citrus pomace fermented with combined probiotics improves growth performance, meat quality, fatty acid profile, and antioxidant capacity in yellow-feathered broilers
Authors: Liu Yanchen , Tang Yantian , Mei Huadi , Liu Zhichang , Li Zhenming , Ma Xianyong , Luo Zhihui , Huang Weiwen , Li Yuanfei , Yu Miao 
Published: December 2024

IntroductionThe reasonable and efficient utilization of agricultural by-products as animal feed has the capacity to not only mitigate the scarcity of conventional feedstuff but also alleviate the environmental load. This study was aimed to investigate the effects of feeding citrus pomace (CP) fermented with combined probiotics on growth performance, carcass traits, meat quality and antioxidant capacity in yellow-feathered broilers.MethodsA cohort of 540 female yellow-feathered broilers (Qingyuan partridge chicken, 90-day-old) were randomly divided into three groups and, respectively, fed the basal diet (Control), diet containing 10% unfermented CP (UFCP) and diet containing 10% fermented CP (FCP).ResultsThe results showed that dietary FCP significantly increased (p &lt; 0.05) the final-body-weight and average-daily-gain of broilers, and the pH45 min and b*24 h values in breast muscle, while tendentiously lowering the feed-to-gain ratio (p = 0.076). The levels of inosine monophosphate (p &lt; 0.05) and intramuscular fat (p = 0.083) in the FCP group were higher than those in the control group. Remarkably, dietary FCP and UFCP increased the levels of polyunsaturated fatty acids (PUFAs) and n-6 PUFAs (p &lt; 0.05). Moreover, dietary FCP decreased (p &lt; 0.05) the malondialdehyde content and increased (p &lt; 0.05) the glutathione peroxidase content in serum. Ingestion of FCP and UFCP increased the levels of total antioxidant capacity and catalase activity in serum, and concentrations of glutathione peroxidase and catalase in breast muscle (p &lt; 0.05). Additionally, diet containing FCP or UFCP upregulated the expression of SREBP − 1c, FAS, NRF2, GSH-Px, and CAT in breast muscle (p &lt; 0.05).DiscussionOverall, dietary supplementation with FCP obviously improved meat quality, enhanced the antioxidant capacity and regulated the lipid metabolism, contributing to the improvement of growth performance of yellow-feathered broilers.
Retrospective analysis of custom 3D-printed drill guides and titanium plate use in spinal stabilization of eleven dogs
Authors: Guirguis Phillip , Asanovic Ilja , Beggs David S. , Long Sam N. 
Published: December 2024

IntroductionCongenital vertebral malformations are common developmental abnormalities in screw-tailed brachycephalic dog breeds. Subsequent vertebral instability and/or vertebral canal stenosis caused by these malformations can lead to spinal cord compression manifesting in pain, paraparesis, ataxia and/or paralysis. Various methods for spinal stabilization are in common use. However, these are without significant risk due to narrow margins of surgical error and variable vertebral anatomy. We evaluate a novel method for spinal stabilization where a custom 3D-printed plate is created and surgically fitted to the patient’s spine using custom 3D-printed drill guides.ObjectiveTo describe the surgical technique and short-term outcomes in patients treated with custom 3D-printed plates and drill guides.MethodA retrospective analysis of 11 dogs from two referral hospitals which underwent this procedure was undertaken. Post-operative CT scans were assessed for spinal canal screw perforation using the modified Zdichavsky classification. Pre-operative and post-operative neurological status were assessed using the Modified Frankel Scale and the surgical technique including post-operative imaging and recovery findings were described.ResultsOptimal screw placement (grade I) was achieved in 63% of placed screws across the eleven dogs. Partial penetration of the medial wall (grade IIa) was observed in 3% of screws and partial penetration of the lateral wall (grade IIIa) was observed in 29% of screws. Full penetration of the lateral pedicle wall (grade IIIb) was observed in 5% of screws and no screws fully penetrated the medial vertebral wall (grade IIb).DiscussionWe demonstrated that custom 3D-printed drill guides and titanium plates can provide a safe peri-operative alternative for surgical spinal stabilization of dogs with vertebral column instability due to congenital vertebral malformations. Further research is needed to describe long-term outcomes of this surgical technique on patient health.
Calculation of the Breit–Rosenthal Effect in Bi I
Authors: Røger Tarje Arntzen , Persson Jonas R. 
Published: December 2024

Corrections to the measured nuclear magnetic moments obtained from hyperfine structure measurements include the Breit–Rosenthal effect. In this paper, we present results from calculations on Bi using the GRASP2018 code. The results indicate that the Breit–Rosenthal effect is on the order of 0.1%fm−2, the same order of magnitude as neighbouring elements, while some atomic states may have one order of magnitude smaller values. The ground state 6p3 S3/2o4 is more sensitive to the Breit–Rosenthal effect, and hence the hyperfine anomaly, with a value of −0.25%fm−2.
Improving the Methodology for Intra-Annual Distribution of the Volume of Unobserved Agricultural Production in Russia
Authors: Filippova N. I. , Pershina T. A. , Parshintseva L. S. 
Published: December 2024

The article addresses improving the methodology for distributing the annual volume of unobserved agricultural production in Russia by month.The study used methods for calculating averages and variances, dispersion analysis and the index method.The study aims to explain the algorithm for distributing the annual volume of agricultural production by month to improve the quality of official statistical information. The authors analyzed existing approaches to the distribution of agricultural output, reviewed the experience of other countries in the subject area of the study, and formulated methodological recommendations for distributing the volume estimates of the output of unobserved types of agricultural production by month.Official statistical methodology, published results of scientific research by Russian and foreign scientists, current regulatory legal acts of the Russian Federation and other countries in the subject area, and agricultural calendars for the period under review served as a theoretical foundation for this work.The scientific novelty of the conducted study lies in developing scientific and methodological recommendations for the distribution of agricultural production volumes in actual prices by month to improve the objectivity of official statistics. The relevance of the study stems from the need to refine the existing approaches to the distribution of the annual volume of agricultural production.
On the Sources of Primary Data for Official Statistics in Russia
Authors: Surinov A. Ye. 
Published: December 2024

The article covers the issues of primary data sources’ transformation for the production of official statistics. This topic is in sight of the UN Statistical Commission and its committees and working groups. The global statistical community and national statistical systems have faced a new challenge – the data revolution. This phenomenon is associated with the ever-expanding digitalization of all aspects of modern life and the emergence of new sources of information that are not the result of classical statistical observations. In some countries, administrative statistics have replaced the collection of primary data. They have practically abandoned surveys and reporting.In recent decades, the phenomenon of Big Data has declared itself as a source of operational and detailed information on many phenomena in society, economy and environment. National statistical systems are faced with a choice of how to organize data collection in the modern world most effectively. For the international statistical community, the results of this discussion are of decisive importance in working out a development strategy, including ensuring conditions for the integration of information resources and the creation of tools for managing data obtained from various sources. The author considers the change of data sources, given the need to reduce the statistical burden on society by reducing budget expenditures and the time respondents spend preparing and providing information.
Основные факторы риска развития артериальной гипертензии и ожирения у неорганизованного населения Навоийской области Узбекистана
Authors: Ахмедов М.Э. , Хамраев Р.И. , Агабабян И.Р. , Юсупова З.К. 
Published: December 2024

Цель. Оценка распространенности артериальной гипертензии (АГ) и связанного с ней ожирения как основных факторов риска среди населения Навоийской области Узбекистана, а также частоты ассоциированных клинических состояний (АКС) среди пациентов с АГ. Материалы и методы. В исследовании принимало участие неорганизованное мужское и женское население, проживающее в городе Навои и сельской местности, за 2023 г. Формирование выборок проходило по стандартной методике и осуществлялось в 1 этап. Отбиралось по 1 случайно выбранному врачебному участку города и сельской местности, обслуживающих от 1,8 до 2 тыс. человек (в возрасте 19–64 лет). Результаты. Распространенность АГ среди обследованных лиц городского населения составляла 35,2%, а сельского – 27,9%. Согласно полученным данным, распространенность АГ превалирует среди городского населения по сравнению с сельским населением (35,2 и 27,9% соответственно, р<0,05). Заключение. Своевременная оценка эпидемиологической ситуации с анализом причин развития заболевания, связанных с ними коморбидных состояний, осложнений и смертности, грамотный выбор антигипертензивных препаратов (АГП), коррекция имеющихся факторов риска должны привести к существенному снижению сердечно-сосудистых осложнений, таких как инфаркт миокарда и инсульт.
Purpose. To assess the prevalence of hypertension and associated obesity as the main risk factors among the population of the Navoi region of Uzbekistan, as well as the frequency of associated clinical conditions among patients with hypertension. Materials and methods. Unorganized male and female population living in the city of Navoi and rural areas in 2023 was involved in the study. The sampling was carried out according to the standard methodology in one step. One urban and one rural medical site were randomly selected, providing medical services for 1.8 to 2 thousand residents (aged 19–64 years). Results. The prevalence of hypertension in the studied urban population was 35.2%, while in the studied rural population it was 27.9%. According to the data obtained, AH prevailed in the urban population compared to the rural population (35.2 and 27.9%, respectively, p<0.05). Conclusion. Timely assessment of the epidemiological situation with analysis of the causes of the disease, associated comorbid conditions, complications and mortality, competent choice of antihypertensive drugs, and correction of existing risk factors should lead to a significant reduction in the risk of cardiovascular complications.
Применение апиксабана в реальной клинической практике: обзор литературы
Authors: Плащинская Л.И. 
Published: December 2024

Фибрилляция предсердий – самая частая аритмия в практике кардиолога, без антикоагулянтной терапии может осложняться инсультом. В данной статье определены основные вопросы врача общей практики, терапевта, кардиолога в отношении использования апиксабана с целью профилактики тромбоэмболических рисков. Рассмотрен выбор прямого орального антикоагулянта у отдельных групп пациентов с клинической фибрилляцией предсердий, в том числе у пожилых лиц и хрупких пациентов, а также с высоким риском геморрагических осложнений. Приведены основные исследования сравнения апиксабана с варфарином и ацетилсалициловой кислотой. Рассмотрены вопросы использования апиксабана при нарушении почечной и печеночной функций, а также преимущества его двукратного применения. На основании обзора определены основные шаги в инициации антикоагулянтной терапии. Уделено внимание тактике ведения пациентов, которые перенесли эпизод острой тромбоэмболии легочной артерии и/или имели тромбоз глубоких вен ног, и использованию апиксабана для профилактики тромбоэмболических осложнений у онкологических пациентов.
Atrial fibrillation is the most frequent arrhythmia in cardiologists’ practice, which, if not managed with anticoagulant therapy, can be complicated by strokes. The article outlined the main questions of general practitioners, therapists, and cardiologists concerning the use of apixaban to prevent thromboembolic risks. The choice of a direct oral anticoagulant in selected patient populations with clinical atrial fibrillation, including the elderly and fragile patients, as well as those at high risk of hemorrhagic complications, is discussed. The main studies comparing apixaban with warfarin and acetylsalicylic acid are presented. The use of apixaban in renal and hepatic dysfunctions and advantages of its twice-daily administration are covered. Based on the review, the main steps in anticoagulation therapy initiating are defined. The tactics of managing patients who underwent an episode of acute pulmonary embolism and/or had deep leg vein thrombosis and using apixaban to prevent thromboembolic complications in cancer patients are emphasized.
SOSIALISASI TERKAIT MODAL USAHA DI MASYARAKAT DESA KAMPUNG JERUK KECAMATAN BINDURIANG
Authors: Melati Puspa Sari  , Juita Helfiliani  , Hilyati Milla  
Published: December 2024

Pemberdayaan ekonomi masyarakat merupakan salah satu aspek yang sangat penting dalam upaya pembangunan berkelanjutan. Oleh karena itu kami selaku mahasiswi dan mempunyai kewajiban dalam mengabadikan diri pada masyarakat untuk meng-sosialisasi terkait modal usaha. Salah satu tantangan utama yang sering dihadapi oleh pelaku UMKM adalah akses dan pengelolaan modal usaha. Modal usaha yang memadai tidak hanya diperlukan untuk memulai usaha tetapi juga untuk mengembangkan dan mempertahankan keberlanjutannya di pasar yang kompetitif. Sosialisasi yang efektif dapat meningkatkan pengetahuan masyarakat tentang berbagai sumber dan mekanisme pendanaan, serta strategi pengelolaan yang efisien.
Kegiatan sosialiasi yang dilakukan oleh kami dalam rangka meningkatkan pemahaman masyarakat tentang modal usaha. Fokus utama dari program ini adalah untuk mengedukasi pelaku UMKM mengenai berbagai sumber modal yang tersedia, cara mengaksesnya, dan cara mengelola modal dengan baik. Dengan pendekatan ini, diharapkan masyarakat tidak hanya memperoleh informasi yang diperlukan tetapi juga mampu mengimplementasikan pengetahuan tersebut dalam praktik usaha mereka. Melalui pendampingan, pelatihan, dan seminar, program ini bertujuan untuk memperkuat kapabilitas ekonomi lokal dan mendukung pertumbuhan UMKM secara berkelanjutan.

Kata kunci :Mengatur,Modal Usaha,Kepala Curup
AN ANALYSIS OF STUDENTS’ ERRORS USING SIMPLE PAST TENSE IN WRITING NARRATIVE TEXT AT GRADE X OF MAS TELADAN UJUNG KUBU IN 2023/2024 ACADEMIC YEAR
Authors: Sidabalok Hamidah , Hasibuan Derliana , Sambayu Harry 
Published: December 2024

The goal of this study was to assess students' procedural text writing skills. This study was conducted at MAS Teladan Ujung Kubu. One month was allotted for this study's duration. This study used a descriptive, quantitative research design. Random sampling was the technique used to collect the sample. The four classes of grade X pupils that made up the research population were all of them. There were 159 pupils in all, 40 students in each of the three classes and 39 students in the single class. The researcher selected X-4, including 39 pupils, as the research sample because this study used descriptive quantitative methods. A test was one of the research's instruments. It was an essay-based test. Keywords : Kabupaten Asahan, Errors Analysis, Writing, Narrative Text.
ГЛОССАРИЙ: ГЛОБАЛЬНОЕ ИЗМЕНЕНИЕ КЛИМАТА
Authors: Потапов И.И. , Камнева И.Е. , Юдин А.Г. 
Published: December 2024

Глоссарий - словарь узкоспециализированных терминов какой-либо отрасли знаний с толкованием иногда переводом на другой язык, комментарием и примерами. Сейчас издаются многие справочные издания подзаголовком «Глоссарий», то есть понятием «глоссарий» часто определяют просто словарь, который объясняют малоизвестные слова и выражения в какой-либо области знаний Данный обзор составлен на основе отбора и изучения данный научных статей и обзоров зарубежных ученых и специалистов ряда стран мира в соответствии с выполнением планов научной деятельности ВИНИТИ РАН.
This review is based on the selection and study of data from scientific articles and reviews of foreign scientists and specialists from a number of countries in accordance with the implementation of the research plans of VINITI RAS.
ИСТОРИЯ РАЗВИТИЯ ПОДХОДОВ К КАЧЕСТВЕННОЙ ОЦЕНКЕ, КЛАССИФИКАЦИИ И ФУНКЦИОНАЛЬНОМУ ЗОНИРОВАНИЮ ТЕРРИТОРИЙ ДЛЯ ЦЕЛЕЙ РАЦИОНАЛЬНОГО ЗЕМЛЕ- И ПРИРОДОПОЛЬЗОВАНИЯ (ОТ ДРЕВНЕГО МИРА ДО НОВОГО ВРЕМЕНИ)
Authors: Янин Е.П. 
Published: December 2024

В статье рассматривается история развития подходов к качественной оценке, классификации и функциональному зонированию территорий для целей рационального земле- и природопользования в период от Древнего мира до Нового времени.
The article examines the history of the development of approaches to the qualitative assessment, classification and functional zoning of territories for the purposes of rational land and nature management in the period from the Ancient World to Modern times.
ОСОБЕННОСТИ АДАПТИВНОЙ ИЗМЕРИТЕЛЬНОИНФОРМАЦИОННОЙ СИСТЕМЫ МОНИТОРИНГА ВОДНОЙ СРЕДЫ ПО ДАННЫМ МИКРОВОЛНОВЫХ И ОПТИЧЕСКИХ ИЗМЕРЕНИЙ
Authors: Мкртчян Ф.А. , Климов В.В. , Солдатов В.Ю. , Красножен Л.А. , Мкртчян М.А. 
Published: December 2024

В данной работе предлагается в результате соединения систем сбора многоканальной дистанционной информации (СВЧ и оптической), моделей функционирования исследуемого участка водной среды и средств искусственного интеллекта синтезировать ГИМС-технологию, обеспечивающую прогнозные оценки функционирования соответствующего участка гидросферы. Ожидаемые от данной работы результаты позволят оперативно оценивать температуру, минерализацию (соленость), волнение водной поверхности, концентрацию неорганических и органических веществ и т.д. с обеспечением прогнозных оценок и выделением аномальных участков.
In this paper, we propose as a result of the connection systems for the collection of multi-channel remote information (microwave and optical) models of functioning of the investigated area the water environment and artificial intelligence to synthesize GIMStechnology that delivers forward-looking assessment of the functioning of the corresponding portion of the hydrosphere. Expected results from this work will allow us to evaluate the temperature, salinity (saltiness), the concentration of inorganic and organic substances, etc. ensuring the release of forward-looking estimates and abnormal areas.
Оценка надежности стальных ферм как многоэлементных систем по критерию прочности
Authors: Свентиков А.А. 
Published: December 2024

Постановка задачи. Рассмотрена задача об оценке надежности стальных ферм как многоэлементных систем по критерию прочности. Результаты. Предложено оценивать вероятность разрушения отдельного стержня по методу двух моментов. Для оценки надежности ферм как многоэлементных систем в них выделяются цепочки главных элементов. Предложенная методика проиллюстрирована на примере рассмотрения плоскостной фермы, при этом сопоставлены результаты оценки надежности по отдельному элементу, как системы последовательно соединенных элементов и по предложенной методике. Выводы. Предложена методика оценки надежности стальных ферм по критерию прочности, в основе которой метод двух моментов, а также принцип передачи нагрузки в элементах фермы по цепочкам главных элементов.
Statement of the problem. The problem of assessing the reliability of steel trusses as multi-element systems according to the strength criterion is considered. Results. It is proposed to estimate the probability of destruction of an individual rod using the two-moment method. To assess the reliability of farms as multi-element systems, chains of main elements are distinguished in them. The proposed technique is illustrated by the example of considering a planar shape. At the same time, the results of the reliability assessment for a single element, as a system of sequentially connected elements and according to the proposed methodology, are compared. Conclusions. A method for assessing the reliability of steel trusses by the strength criterion is proposed, which is based on the two-moment method, as well as the principle of load transfer in the truss elements along the chains of the main elements.