bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medullary thyroid carcinoma in children: current state of the art and future perspectives
Authors: Kiriakopoulos Andreas , Dimopoulou Anastasia , Nastos Constantinos , Dimopoulou Dimitra , Dimopoulou Konstantina , Menenakos Evangelos , Zavras Nikolaos 
Published: September 2021

Abstract
Medullary thyroid carcinoma (MTC) is a distinct type of malignant thyroid tumor in cell origin, biological behavior, and natural history. It accounts for 1.6% of all thyroid cancers and presents either sporadically or as a hereditary disease, the latter occurring as a part of multiple endocrine neoplasia (MEN) 2A and MEN2B syndromes or as a familial MTC disease with no other manifestations. The gene responsible for the hereditary form is the rearranged during transfection (RET) gene, a proto-oncogene located to human chromosome 10. Most pediatric MTC cases have been discovered after genetic testing investigations, leading to the concept of prophylactic surgery in presymptomatic patients. Therefore, the genetic status of the child, along with serum calcitonin levels and ultrasonographic findings, determine the appropriate age for prophylactic surgical intervention. Nevertheless, a diagnosis at an early stage of MTC warrants total thyroidectomy and central lymph node dissection with the addition of lateral/contralateral lymph node dissection depending on the tumor size, ultrasonographic evidence of neck disease, or calcitonin levels. Conversely, locally advanced/unresectable or metastatic MTC is primarily treated with multikinase inhibitors, while more specific RET inhibitors are being tested in clinical trials with promising results.
A grammatical construction in the service of interpersonal distance regulation. The case of the Polish directive infinitive construction
Authors: Kochańska Agata 
Published: September 2021

Abstract
The aim of the paper is to consider the pragmatic effects of the Polish (Proszę) ‘request1 SG. NON-PAST.’ + VINF construction in different contexts. The specific research problem is how these effects are related to the conceptual make-up of the construction. The framework for the analysis is the theory of cognitive grammar (cf. e. g. Langacker 1987, 1991, 2008, 2009).
The analysis starts with an account of the conceptual make-up of the construction. Then, its selected uses are considered, with emphasis on the pragmatic effects in the relevant contexts. The study offers a qualitative analysis of two kinds of data: a sample of hand-picked utterances and a corpus of utterances extracted from the National Corpus of Polish (NCP).
The claim made in the study is that the construction profiles a process figuring in a directive scenario in the role of the process the speaker wishes the hearer to engage in. At the same time, it involves defocusing of the trajector of the profiled process, identified with the hearer. The construction’s pragmatic effects in specific contexts are claimed to follow from how this trajector defocusing is put in correspondence with specific aspects of the actual ground.
Evaluation of ten perennial forage grasses for biomass and nutritional quality
Authors: Faji Mulisa , Kebede Gezahagn , Feyissa Fekede , Mohammed Kedir , Minta Muluneh , Mengistu Solomon , Tsegahun Aschelew 
Published: September 2021

A study was carried out to evaluate 10 perennial forage grass accessions from 4 species for herbage dry matter yield and nutritional quality at Holetta Agricultural Research Center. The evaluated grasses species and varieties were one Desho grass (Pennisetum) variety Kulumsa, four Urochloa decumbens (ILRI-14721, ILRI-14720, ILRI-13205 and ILRI-10871), three Urochloa ruziziensis (ILRI-14813, ILRI-14774 and ILRI-13332) and two Setaria sphacelata (ILRI-143 and ILRI-6543) accessions. Plant height and forage dry matter yield were significantly affected by accession over years, during the establishment and production phases. Combined analysis indicated that the tested accessions varied significantly for plant height with the Setaria accessions taller than the other tested species. Combined data analysis revealed that forage dry matter yield significantly varied according to species and Desho grass (variety Kulumsa) was higher in dry matter yield than the other grasses tested. Fiber contents (NDF, ADF and ADL) were significantly influenced by accession. Crude protein yield differed among the accessions and Desho grass had higher crude protein, followed by U. decumbens (accession ILRI-13205), U. decumbens (accession ILRI-14721) and S. sphacelata (accession ILRI-6543). Based on dry matter yield and crude protein U. decumbens (accession ILRI-13205), U. ruziziensis (accession ILRI-13332), S. sphacelata (accession 6543) and Desho grass (var. Kulumsa) are recommended as alternative forage grasses for the study area and similar agro-ecologies.
A comparative study of divide and conquer, stop and chop and phaco chop techniques of nucleotomy in phacoemulsification
Authors: Dahiya Monika , Kaur Gursimran , Khurana A K , Chawla Urmil 
Published: September 2021

Phacoemulsification is a variant of extracapsular cataract extraction surgery which is the gold standard treatment modality for cataract surgery nowadays. The common nucleotomy techniques of phacoemulsification are divide and conquer, stop and chop and phaco chop.Aim of this studyto compare different techniques of nucleotomy during phacoemulsification with respect to corneal endothelial cell loss, central corneal thickness (CCT) and comment on their merits and demerits. 60 patients undergoing cataract surgery by phacoemulsification were randomly divided into three groups of 20 each (Group A, B and C) who underwent nucleotomy by divide and conquer, stop and chop and phaco chop technique respectively. The preoperative endothelial cell density and central corneal thickness were recorded using Topcon SP3000P non-contrast specular microscope. All patients were followed up at 1, 4 and 12week after surgery and evaluated for vision, slit lamp examination, endothelial cell count and central corneal thickness.The age group of patients studied was 50-80 years, where maximum number of patients were in 51-60 years age group. Out of 60 patients, most common morphological type of cataract was nuclear (40%) cataract followed by cortico-nuclear (36.67%) cataract. After 1 week of surgery, drop in endothelial cell density was 7.06% in Group A, 6.49% in Group B and 6.84% in Group C patients. A further slight decrease in endothelial cell count was recorded during 4week and on final follow up visit at 12 weeks after cataract surgery, there was an endothelial cell loss of 9.51%, 10.9% and 11% in Group A, B and C respectively. The central corneal thickness at 1postoperative week increased by 2.75%, 2.35% and 2.20% in group A, B and C respectively. Further evaluation of CCT at 4and 12 week after surgery showed the values to be almost same as preoperative values. The rate of complications, which mainly included postoperative keratitis, mild anterior uveitis and cystoid macular edema, were found to be almost the same in all the three study groups.All the three nucleotomy techniques of phacoemulsification i.e divide and conquer, stop and chop and phaco chop are equally efficacious in terms of CCT changes, endothelial cell loss and complications rate in the hands of an experienced surgeon.
Factors affecting non-compliance to spectacle wear in children aged six years and below with refractive errors: A hospital based cross-sectional study in India
Authors: Kankonkar Prajoth , Pai Sharvani 
Published: September 2021

Uncorrected refractive errors (RE) are the most common cause of preventable visual Impairment (VI) in children, which if not treated in time can lead to amblyopia. VI in early childhood interferes with their overall development affecting their future opportunities in life. Spectacles remain the most popular and effective method for correction of RE. Children unlike adults, often don’t understand the need for wearing spectacles, thus prescribing spectacles in children becomes difficult. Aim of this study was to find out proportion of spectacle wear non-compliance in children aged six years and below and identify factors associated with it. The study was conducted among 115 children aged six years and below with refractive errors who were prescribed spectacle correction. Children were selected using simple random sampling. Multivariate logistic regression was used to identify independent factors associated with spectacle wear non-compliance. Proportion of spectacle wear non-compliance was 53.04%. Children with spectacle wear non-compliance were more likely to: belong to age of two to four years (AOR = 4.3; 95%CI: 1.3-14.3); have mother with up-to primary school education (AOR = 3.7; 95%CI: 1.2-11.7); have anisometropia (AOR = 11.1; 95%CI: 3.4-36.7). Statistically significant association was observed between spectacle wear non-compliance and child’s age, mother’s education, anisometropia, astigmatism, manifest squint, intolerance to glasses, glasses lost, glasses broken, concerned teasing and cost issues. Children less than four years of age; with anisometropia and those whose mothers had up-to primary school education were more likely to be non-compliant to spectacle wear.
To measure angle of anterior chamber using Topcon SD-OCT: A new technique
Authors: Khan Nida , Agarwal Prakash , Gupta Saroj , Khan Khalid 
Published: September 2021

The proposed new method of measuring angle of anterior chamber is an effective method of measuring the angles. Identification of narrow anterior chamber angle is important for glaucoma screening and prophylactic treatment prevents acute angle closure glaucoma event.Aim of this study wasto measure the angle of anterior chamber using Topcon spectral domain optical coherence tomography (SD OCT).In this cross-sectional study 120 normal subjects above the age of 40 years were enrolled. The study was done at the tertiary health care center of central Indian. All volunteers had visual acuity of at least 6/9 with no ocular diseases. Using OCT the angle opening distance (AOD-500), trabecular–iris angle (TIA) and trabecular-iris space area (TISA-500) were measured. In this study the mean AOD was 0.430 µm in nasal and 0.433 µm in temporal quadrant. The mean TISA in nasal was 0.405 µm and temporal quadrant was 0.408 µm. While the mean trabecular iris angle (TIA) was 26.9° in nasal and 26.01° in temporal quadrant. The study proved that the proposed method of measuring AOD, TISA, TIA is the effective method as the Topcon-2000 OCT does not have any inbuilt software like that of other ASOCT machines.
A prospective observational study for the safety of Nd-YAG Laster posterior capsulotomy procedure in patients of Posterior Capsular Opacification (PCO) at the ophthalmology outpatient department of a tertiary care teaching hospital in western India
Authors: Choudhary Rajendra , Shah Nishant V , Mashru Meet 
Published: September 2021

: Nd YAG laser is preferred method to manage thickened posterior capsule because it is an easy, non-invasive and an OPD basis procedure considering the comfort of the patients.: The present study was carried out with objectives to evaluate the safety profile of Nd-YAG Laser Capsulotomy mainly in terms of rise in intraocular pressure (IOP) and other intra as well as post-operative complications.This prospective observational study was carried out with prior Institutional Ethics Committee (IEC) approval and written informed consent from the participants at Ophthalmology Outpatients Department (OPD) of a tertiary care teaching hospital of western India, for the duration of two years from Oct’2015 to Sept’2017. A detailed ocular, systemic, family history was taken of all the enrolled patients with pre- and post-procedure evaluation of IOP by Goldman’s Applanation Tonometry, Slit lamp examination and Fundus examination by direct and indirect ophthalmoscopy. Capsulotomy was done using VISULAS YAG III laser of Zeiss company.The data was entered and tabulated in Microsoft Excel 2007 and analyzed. Data was analyzed by frequency distribution. The ‘p’ value was determined to finally evaluate and P &#60;0.05 was considered as statistically significant.Acute transient rise of IOP up to 5mmHg or more (P value &#60;0.001) was found in Nine cases which is highly significant compared with pre-procedural stage. Intraocular lens pitting was observed in Four cases. Cystoid macular edema was found in one case. Two patients developed mild iritis. Nd-YAG laser capsulotomy is an easy, practical modality to treat posterior capsular opacities, but is not a completely innocuous procedure. Nd-YAG laser capsulotomy is an easy, practical modality to treat posterior capsular opacities, but is not a completely innocuous procedure. Due precautions should be taken in pre- and post-procedural stages including medications, thorough counselling, proper focusing and steady fixation of the patients to minimise the complication.
FEJLESZTŐPROGRAMOK HATÁSVIZSGÁLATÁNAK MATEMATIKAI STATISZTIKAI ALAPFOGALMAI
Authors: Máth János , Mező Ferenc , Abari Kálmán , Mező Katalin 
Published: September 2021

Pedagógusok, óvodapedagógusok, gyógypedagógusok, fejlesztőpedagógusok, pszichológusok – egy csokorra való azon szakemberek köréből, akik képesség- és/vagy személyiségfejlesztő programokat hozhatnak létre, valósíthatnak meg. E programokkal szemben elvárható azonban, hogy az általuk ígért fejlesztőhatást akár matematikai statisztikai elemzéssel is alá lehessen támasztani. Ez azonban nem mindig történik meg – ennek hátterében pedig részben a matematikai statisztikai fogalmi és módszertani hiányosságok, valamint a drága statisztikai szoftverek állnak. E tanulmány a különleges bánásmódot igénylők számára készült fejlesztőprogramok hatásvizsgálatának matematikai statisztikai elemzéséhez nyújt elméleti összefoglalót.
KONCZ ISTVÁN NAGY KÉZIKÖNYVE TRÉNEREKNEK (Recenzió)
Authors: Mező Ferenc 
Published: September 2021

Az áttekintett könyv:
Koncz István (2015): Sikeres trénerek nagy kézikönyve. FITT IMAGE Kft., Budapest. 412 oldal, ISBN: 978-963-12-3898-3
JÁTÉKKAL A KÜLÖNLEGES BÁNÁSMÓDOT IGÉNYLŐ GYERMEKEKÉRT (RECENZIÓ)
Authors: Varga Gréta 
Published: September 2021

Az áttekintett könyv:
Mező Katalin (Szerk.) (2015): Játékkal a különleges bánásmódot igénylő gyermekekért. Bíbor Kiadó, Miskolc. 122 oldal, ISBN: 978-615-5536-00-7
FACTORS OF PARENTAL INVOLVEMENT IN RELATION TO CHILDREN’S BEHAVIORAL SYMPTOMS
Authors: Kathyné Mogyoróssy Anita , Nagy Erika Beáta 
Published: September 2021

In our study, the features of contact between parents and teachers and the particular patterns they take were examined in connection with children’s behavioral symptoms. With cluster analysis, seven clearly analyzable patterns of contact were identified, the two most frequent of which (unifacial and formal) do not favor problem solving, nor provide parental satisfaction.
Two patterns (flexible and adaptive) proved to be the most satisfying and the most effective. Children’s symptoms (social problems, anxiety, somatization, attention deficit, deviant behavior, aggressivity) are significantly related to the quality of parent-teacher contact. In the case of the less favorable and less effective contact forms, parents report more behavioral symptoms, while in the case of the flexible, adaptive, emotionally satisfying, and effective problem-solving contact forms, there are fewer symptoms. These results draw attention to important tasks on many levels: to work out operable patterns of parent-teacher contact, to better understand the role and tasks of teacher training, and the need to involve experts to assist in developing parent-teacher contact, which is also indispensable in terms of helping and developing children and their mental health.
OLVASÁSI KÉSZSÉG VIZSGÁLATA AFÁZIÁS BETEGEKNÉL A HÁROMUTAS OLVASÁSVIZSGÁLÓ TESZTTEL
Authors: Dankovics Natália , Mokuolu Tímea , Pelyvás Károlyné . 
Published: September 2021

Az afázia, a nyelvi képesség szerzett zavara a szóbeli és az írásbeli kommunikációt egyaránt érinti (Osmanné, 1997, Gósy, 2005). Míg a szóbeli nyelvhasználat vizsgálatára több jól használható, a beteg nyelvi képességének állapotáról átfogó, hiteles képet adó eljárás áll rendelkezésre (Osmanné, 1983, 2007), addig az olvasási készség vizsgálatához csak a WAB olvasásvizsgálat néven ismert teszt érhető el magyar nyelven (Net 1). Mivel ez az eljárás tapasztalatunk szerint nehézkes, értékelése nem egyértelmű, a kapott eredmény pedig nem tükrözi a beteg foglalkozások alatt nyújtott olvasási teljesítményét, célul tűztük ki egy új diagnosztikai eljárás kidolgozását.
Vizsgálóeljárásunk elméleti alapját Ellis és Young egyesített szófelismerési modellje adja (Ellis, 2004). Célunk az egyes olvasási utakon nyújtott teljesítmény feltárása volt annak érdekében, hogy a megtartottnak bizonyult útból kiindulva célzott terápiás módszer alkalmazását tegyük lehetővé a sérült utak helyreállításához.
Motoros túlsúlyú szenzomotoros afáziás betegek körében végzett első vizsgálataink tapasztalata, hogy anyagunk egyszerűen, gördülékenyen használható. Az eredmények azt igazolják, hogy a teszt alkalmas a különböző olvasási utakon nyújtott teljesítmények mérésére, ebből következően megfelelően támpontot ad a terápiás folyamathoz.
MUNKAERŐ-PIACI INTEGRÁCIÓ HATÁSAI, KÜLÖNÖS TEKINTETTEL A MAGATARTÁS ÉS ÉLETMINŐSÉG VÁLTOZÁSAIRA
Authors: Meisznerné Kuklek Noémi , Pusztafalvi Henriette 
Published: September 2021

A bemutatni kívánt program újszerűsége abban rejlik, hogy a mentális, szociális, vagy egészségügyi problémákkal küzdő álláskeresők számára nem csak a foglalkoztatás útján nyújt segítséget, hanem egy komplex, szolgáltatáscsomagot (munkaerő-piaci, szociális, egészségügyi szolgáltatás) is tartalmazó programmal, amely egyénre szabottan tud reagálni a fennálló nehézségekre, ezáltal javítva a résztvevő személyek életminőségét. Jelen tanulmány célja a foglalkoztatásba mentális, szociális vagy egészségügyi okból be nem vonható álláskeresők körében a speciális foglalkoztatási program bevonásának kezdetétől vizsgálni a magatartásbeli változásokat, valamint az életminőség javulását meghatározó tényezőket. Módszer: Vizsgálatunkban az általános jóllétet, megélhetéssel, anyagi háttérrel, családi háttérrel, egészségügyi, mentális problémákkal, munkavégzéshez kötődő problémákkal, szociális szolgáltatások igénybevételeivel, egészségügyi szolgáltatások igénybevételével kapcsolatos változásait monitoroztuk a program öt hónapja során, majd a kapott eredményeket kvantitatív és kvalitatív módszerekkel elemeztük. Következtetések: A jóllétnek mind a munkavállalók szubjektív érzelmi átéléseire, mind munkahelyi teljesítményükre, munkahelyi magatartásukra pozitív hatása van, ezért a társadalomnak érdemes kiemelt figyelmet fordítania a munkáltatók érzékenyítésére, a komplex támogatási csomagot biztosító programok kialakítására, a munkavállalók életminőségének javulását meghatározó munkahelyi tényezők biztosítására. Az életminőség vizsgálatára irányultan eredményeink megerősítették, hogy megfelelő támogatással (pl. mentorálással, tanácsadással, támogató programok révén), növelhető a munkával, a munkahellyel való elégedettség, mely nemcsak az egyén, de a munkaadók, és a társadalom szempontjából is számtalan előnnyel jár: javul a munka minősége, a munkahelyi viselkedés és morál, kevesebb lesz a hiányzás, kisebb a betegségi és a fluktuációs ráta, nő a foglalkoztatottsági ráta.
IS ABSOLUTE PITCH A SPECIAL ABILITY OR SOMETHING WE ALL HAVE? A REVIEW BASED ON GENETIC, NEUROSCIENTIFIC AND EXPERIMENTAL PSYCHOLOGICAL FINDINGS
Authors: Kiss Luca 
Published: September 2021

Absolute pitch (AP), the ability to identify and produce musical pitches without a reference point, is extremely rare and is considered to be a special ability. Although research has focused on this topic for decades, there is no consensus about why AP only occurs in 1 out of 10.000 individuals and how it is acquired. Therefore, the present article aims to review and reconcile the previous findings in order to understand the potential contribution of training and genetics in AP acquisition. Based on experimental psychological and genetic findings, it is concluded that although some components of AP are implicit and exist in the general population, both early musical training and genetic factors are crucial for AP development. This conclusion is supported by neuroscientific findings that provide evidence for differences in activations in specific brain areas between AP possessors and non-possessors.
Quantification By Gas Chromatography of the Content of Amino Acids Present in Sausages Fortified with Quinoa Vegetable Protein
Authors: Zavala A. , González M. , Pino P. 
Published: September 2021

The objective of this research was to determine the quality of the protein present in sausages fortified with quinoa as a substitute for animal protein, through the identification and quantification of amino acids, using gas chromatography and precolumn derivatization. The amino acid composition found in the analyzed products was predominantly composed of: Threonine (THR) with a concentration of 1046.32µmol / L, aminobutyric acid (ABA) with a concentration of 9685.68 µmol / L and glutamic acid (GLU) with a concentration of 1178.71 µmol / L. These values were found in the treatment with the highest percentage of quinoa flour, establishing a directly proportional relationship between the concentrations of these amino acids and the percentage of quinoa. Gas chromatography was an adequate technique for determining the amino acid profile due to its speed and sensitivity.
Keywords: amino acids, sausages, quinoa, derivatization, gas chromatography.
RESUMEN
La presente investigación tiene por objetivo determinar la calidad de la proteína presente en embutidos fortificados con quinua como sustituyente de la proteína animal, a través de la identificación y cuantificación de aminoácidos mediante la aplicación de cromatografía de gases y la derivatización precolumna. La composición de aminoácidos encontrada en los productos analizados destaca la presencia mayoritaria de: Treonina (THR) con una concentración de 1046,32 µmol/L, ácido aminobutírico (ABA) con una concentración de 9685,68 µmol/L y ácido glutámico (GLU) con una concentración de 1178,71 µmol/L, todos estos valores se presentaron en el tratamiento con mayor porcentaje de harina de quinua estableciéndose una relación directamente proporcional entre las concentraciones de estos aminoácidos y el porcentaje de adición de quinua en los tratamientos estudiados. Se puede concluir que la cromatografía de gases empleada resultó una técnica adecuada para la determinación del perfil aminoacídico por la rapidez y sensibilidad presentada sobre las muestras estudiadas.
Palabras claves: aminoácidos, embutidos, quinua, derivatización, cromatografía de gases.