bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct Economic Loss‐Based Seismic Design Using Genetic Algorithm
Authors: Li Cuihua , Guo Yu , Kunnath Sashi 
Published: January 2025

ABSTRACTEarthquake‐induced economic losses in buildings are likely to escalate as urbanization accelerates. Traditional seismic optimization methods, such as consistent ductility‐based design, aim to achieve uniform story drift along the building height but do not directly address reduction in economic losses. This study presents an innovative method called direct loss‐based design (DLBD) using a genetic algorithm to minimize the expected annual loss (EAL) in RC frame structures conditioned on constant structural stiffness and construction cost. Two optimization frameworks for minimizing the expected losses (EL) are examined: intensity‐based and risk‐based. Intensity‐based optimization focuses on a specific intensity level, whereas risk‐based optimization considers the EAL across three seismic hazard levels. Additionally, the collapse probability (CP) of structures optimized via the DLBD method is evaluated. Results show that intensity‐based optimization significantly reduces EL at the target intensity level but is ineffective at other seismic intensities due to extremely increased seismic demands at some floors. Conversely, the risk‐based optimization substantially reduces both EAL and CP across all intensity levels assessed, with a maximum reduction of 31% and an average reduction of over 20% for EAL, as well as an average decrease of 62% for CP. This approach effectively decreases seismic demands while simultaneously distributing the story drifts evenly across the building height. The proposed risk‐based design framework not only offers a practical algorithm for seismic optimization targeting EL but also provides new avenues to explore resilience‐based seismic design approaches.
Solutions to Two‐ and Three‐Dimensional Incompressible Flow Fields Leveraging a Physics‐Informed Deep Learning Framework and Kolmogorov–Arnold Networks
Authors: Jiang Quan , Gou Zhiyong 
Published: January 2025

ABSTRACTPhysics‐informed neural network (PINN) has become a potential technology for fluid dynamics simulations, but traditional PINN has low accuracy in simulating incompressible flows, and these problems can lead to PINN not converging. This paper proposes a physics‐informed neural network method (KA‐PINN) based on the Kolmogorov–Arnold Neural (KAN) network structure. It is used to solve two‐dimensional and three‐dimensional incompressible fluid dynamics problems. The flow field is reconstructed and predicted for the two‐dimensional Kovasznay flow and the three‐dimensional Beltrami flow. The results show that the prediction accuracy of KA‐PINN is improved by about 5 times in two dimensions and 2 times in three dimensions compared with the fully connected network structure of PINN. Meanwhile, the number of network parameters is reduced by 8 to 10 times. The research results not only verify the application potential of KA‐PINN in fluid dynamics simulations, but also demonstrate the feasibility of KAN network structure in improving the ability of PINN to solve and predict flow fields. This study can reduce the dependence on traditional numerical methods for solving fluid dynamics problems.
Heat and Mass Transport in Magnetized CNT‐Infused Hybrid Ellis Nanofluid Flow Over a Porous Stretching Surface
Authors: Pooja M. N. , Narasimhamurthy S. K. , Vajravelu Kuppalapalle 
Published: January 2025

ABSTRACTThe overarching aim of this study is to investigate the enhancement of thermal energy and mass transfer in the flow of Ellis hybrid nanofluid under a magnetic field across a porous stretching surface. This advanced hybrid nanofluid is formulated by dispersing single‐walled and multiwalled carbon nanotubes (CNTs) within a non‐Newtonian Ellis fluid. The research meticulously analyzes the complex interactions of velocity, heat, and mass transport influenced by thermal radiation, nonuniform heat sources/sinks, Joule heating, and Arrhenius activation energy. The governing nonlinear partial differential equations are skillfully transformed into ordinary differential equations through elegant similarity transformations, and the resulting dimensionless equations are solved semianalytically using the sophisticated Homotopy Analysis Method. The key findings indicate that viscous dissipation and heat generation significantly elevate energy profiles, while Arrhenius activation energy profoundly boosts mass transfer rates. Additionally, the integration of CNTs into the Ellis fluid enhances both velocity and energy fields, demonstrating remarkable improvements in heat and mass transfer efficiency. The Ellis hybrid nanofluid holds immense potential for applications in engineering and industrial processes, including polymer extrusion, food processing, and pharmaceutical manufacturing, where precise control of shear‐thinning fluid behavior is vital for optimizing performance.
Curvilinear incidence models for parity in the entire fertility range for cancers of the breast, ovary, and endometrium: A follow‐up of the Norwegian 1960 Census
Authors: Lund Eiliv , Busund Lill‐Tove Rasmussen , Holden Lars 
Published: January 2025

AbstractThe protective effect of parity has been demonstrated for cancer of the breast, ovary, and endometrium but no studies have estimated the effect of each subsequent birth in women with 10 or more children or grand‐grand parity women, nor compared the linear relationship of the three cancers sites. Here, we aim to explore these relationships based on the Norwegian 1960 Census. The question of parity in present marriage was answered by 385,816 women born 1870–1915, a period with high fertility. Age at marriage has been validated as a proxy for age at first birth AFB. With high parity age at first birth will logically be restricted to early births giving structural zeros. Follow‐up was based on linkages to national registers until the first of any of the three diagnoses, death, or age 90 before 31.12.2005. Included were 16,905 breast cancers, 3827 ovarian cancers, and 3834 endometrial cancers. Age‐ and period‐specific incidence rates based on person‐years, PY, were used in logit regression models. The percentage decrease for each additional child over the total parity range was for breast cancer 10.5% (95% CI; 9.6–11.4), ovarian cancer 13.2% (11.2–15.3), and endometrial cancer 10.9% (8.9–12.8), in a model without higher order terms. Adjustment for structural zeros reduced the effect of age at first birth to less than one additional child. To the best of our knowledge this is the first analysis of the curvilinear relationships for cancers of the breast, ovary, and endometrium throughout the extended fertility range.
Potential for enhancing efficacy of screening colonoscopy by lowering starting ages and extending screening intervals: A modelling study for Germany
Authors: Sergeev Dmitry , Heisser Thomas , Hoffmeister Michael , Brenner Hermann 
Published: January 2025

AbstractStudies aimed to evaluate the expected impact of alternative screening strategies are essential for optimizing colorectal cancer (CRC) screening offers, but such studies are lacking in Germany, where two screening colonoscopies (CS) 10 years apart are offered for men from age 50 and women from age 55. Our aim was to explore whether and to what extent the efficacy of utilizing two CS could be enhanced by alternative starting ages and screening intervals. We modeled the expected numbers of CRC cases, CRC deaths, years of potential life lost (YPLL), and disability‐adjusted life years (DALYs) due to CRC in hypothetical cohorts of 100,000 men and women aged 45–85 using COSIMO, a validated Markov‐based multi‐state simulation model. Modeled strategies included combinations of starting ages (45/50/55/60) and CS (10/15/20 years). For men, CRC deaths could be slightly reduced by extending the interval to 15 years, with a second CS at 65. YPLL and DALYs would be reduced by decreasing starting age to 45 when combined with a 15‐year screening interval. For women, use of two CS at ages 50 and 65 would reduce all CRC burden parameters compared to the current earliest‐use offer at 55 and 65 years. Our results suggest that lowering the starting age of screening colonoscopy to 45 for men and 50 for women, combined with extending the CS screening interval to 15 years would have the potential to enable significant reductions in years of potential life lost, and disability‐adjusted life years compared to current screening offers in Germany.
A case of testicular dysgenesis syndrome with squamous cell carcinoma of the prostate harboring a CDK12 mutation
Authors: Murata Yasuaki , Kosaka Takeo , Nakamura Kohei , Baba Yuto , Arai Eri , Yasumizu Yota , Matsumoto Kazuhiro , Nishihara Hiroshi , Oya Mototsugu 
Published: January 2025

IntroductionPrimary squamous cell carcinoma of the prostate is rare, and genetic profiling of this disease has not been established yet.Case presentationWe present a case of primary squamous cell carcinoma in a patient with testicular dysgenesis syndrome. The patient was diagnosed with prostate squamous cell carcinoma following intractable dysuria, and his serum prostate‐specific antigen level was low. The patient had multiple lymph node and lung metastases, which led to administration of platinum‐based chemotherapy. Additionally, targeted next‐generation genome sequencing was performed to detect CDK12 mutations.ConclusionEarly imaging studies should be considered, even if the patient's prostate‐specific antigen level is low when dysuria persists despite medical treatment. To the best of our knowledge, this is the first reported case of primary squamous cell carcinoma with a CDK12 mutation in a patient with TDS.
A case of suspected paraneoplastic nerve syndrome associated with prostate cancer or opsoclonus‐myoclonus syndrome associated with COVID‐19 infection, but symptoms improved after treatment of both
Authors: Tomomasa Naoya , Kayano Sotaro , Monzen Tatsuya , Shimomura Tatsuya , Kimura Takahiro 
Published: January 2025

IntroductionParaneoplastic neurological syndrome is a type of neurological syndrome that occurs in patients with cancer; however, it is rarely associated with prostate cancer. We herein report a rare case of this condition.Case presentationA 76‐year‐old man, treated conservatively for rotatory vertigo due to a subtype of Guillain–Barré syndrome after COVID‐19, was referred to our neurology department. Magnetic resonance imaging showed no obvious findings; however, paraneoplastic neurological syndrome was suspected due to opsomyoclonus, and close examination of the primary tumor revealed a high prostate‐specific antigen level and bone metastases, suggesting prostate cancer. Paraneoplastic nerve syndrome associated with prostate cancer was suspected. Since the possibility of OMS associated with COVID‐19 infection was considered, bilateral orchiectomy and endocrine therapy, as well as pulse steroid therapy, were performed, and the patient's symptoms resolved.ConclusionThis rare case suggests the need for timely and aggressive treatment for prostate cancer–associated paraneoplastic nerve syndrome.
The Roles of Interpersonal and Intrapersonal Emotion Regulation on Psychological Distress: A Longitudinal Panel Study
Authors: Akkuş Koray , Peker Mehmet , Ceren Gökdağ  
Published: January 2025

ABSTRACTThe present study was designed to test the hypothesis that interpersonal emotion regulation leads to increased difficulties in intrapersonal emotion regulation, which in turn, leads to general psychological distress utilizing a three‐wave cross‐lagged panel design. Undergraduate students rated self‐report measurements of interpersonal emotion regulation, difficulties in intrapersonal emotion regulation, and psychological distress at baseline (T1, N = 369) and two follow‐up waves (T2 and T3), each separated by 3 months. The results indicated that although some lagged correlations between interpersonal emotion regulation strategies and difficulties in intrapersonal emotion regulation were significant, interpersonal emotion regulation strategies did not prospectively predict difficulties in intrapersonal emotion regulation. Notably, difficulties in intrapersonal emotion regulation significantly predicted psychological distress in subsequent waves. Additionally, psychological distress at T1 predicted distress at T3 through difficulties in intrapersonal emotion regulation at T2. This study is significant as it is the first to test the interpersonal emotion regulation model in a longitudinal design. However, the hypothesized pathway where interpersonal emotion regulation contributes to psychological distress through difficulties in intrapersonal emotion regulation, was not supported.
A Longitudinal Prediction of Suicide Attempts in Borderline Personality Disorder: A Machine Learning Study
Authors: Fortaner‐Uyà Lidia , Monopoli Camilla , Cavicchioli Marco , Calesella Federico , Colombo Federica , Carretta Ilaria , Talè Chiara , Benedetti Francesco , Visintini Raffaele , Maffei Cesare , Vai Benedetta 
Published: January 2025

ABSTRACTBorderline personality disorder (BPD) is associated with a high risk of suicide. Despite several risk factors being known, identifying vulnerable patients in clinical practice remains a challenge so far. The current study aimed at predicting suicide attempts among BPD patients during disorder‐specific psychotherapeutic interventions exploiting machine learning techniques. The study took into account several potential predictors relevant to BPD psychopathology: emotion dysregulation, temperamental and character factors, attachment style, impulsivity, and aggression. The sample included 69 patients with BPD who completed the Temperament and Character Inventory, Attachment Style Questionnaire, Difficulties in Emotion Regulation Scale, Barratt Impulsiveness Scale, and Aggression Questionnaire at baseline and after 6 months of psychotherapy. To detect future suicide attempts, baseline questionnaires were entered as predictors into an elastic net penalized regression, whose predictive performance was assessed through nested fivefold cross‐validation. At the same time, 5000 iterations of a non‐parametric bootstrap were used to determine predictors’ robustness. The elastic net model discriminating BPD suicide attempters from non‐attempters reached a balanced accuracy of 64.09% and an area under the receiver operating curve of 70.44%. High preoccupation with relationships, harm avoidance, and reward dependence, along with low motor impulsiveness, verbal aggression, cooperativeness, and self‐transcendence were the most contributing predictors. Our findings suggest that interpersonal vulnerability and internalizing factors are the strongest predictors of future suicide attempts in BPD. Machine learning on self‐report psychological scales may be helpful to identify individuals at suicidal risk, potentially helping clinical settings to develop individualized preventive strategies.
Return to sports after unilateral medial opening wedge high tibial osteotomy in highly active patients: Analysis of factors affecting functional recovery
Authors: Nakayama Hiroshi , Kanto Ryo , Onishi Shintaro , Iseki Takuya , Nakao Yoshitaka , Tachibana Toshiya , Amai Kenta , Yoshiya Shinichi , Iseki Tomoya 
Published: January 2025

AbstractPurposeThe purpose of this study was to examine the outcomes following opening‐wedge high tibial osteotomy (HTO) focusing on return to sports in a consecutive series of highly active patients who underwent a unilateral osteotomy procedure.MethodsSixty‐three consecutive patients with preoperative Tegner's activity score of five or more who underwent unilateral HTO for varus osteoarthritic knees were included in this study. The clinical results were evaluated using the Knee Injury and Osteoarthritis Outcome Score (KOOS) and the International Knee Documentation Committee (IKDC) Subjective Score. In radiological assessment, the following parameters were measured in full‐length weight‐bearing radiographs both pre‐ and postoperatively; mechanical tibiofemoral angle (mTFA), mechanical medial proximal tibial angle (mMPTA) and joint‐line convergence angle. As regard postoperative functional recovery, inability to return to sports activities and reduction in the activity level on the Tegner scale were considered as failure to return to sports. Potential prognostic factors examined with logistic regression analysis were as follows: age ≥ 70, body mass index > 25, postoperative mTFA > 3° valgus or <0° varus, postoperative mMPTA > 90°, opening gap > 10 mm and Kellgren–Laurence classification (KL) grade 4.ResultsAt 2 years after surgery, the KOOS and the IKDC score improved from 231 to 437 and from 34 to 72, respectively, with significant improvements in both scores. As for functional recovery, 50 patients (79.4%) could return to high‐impact sports activities at the presymptomatic level with a mean time period of 8.0 months. Statistical analysis of the prognostic factors showed that postoperative mTFA > 3° valgus, opening gap >10 mm and KL grade 4 were the factors significantly affecting the postoperative return to sports.ConclusionsPresence of postoperative mTFA > 3° valgus, opening gap >10 mm and KL grade 4 were identified as risk factors impairing postoperative return to high‐impact sports.Level of EvidenceLevel Ⅳ.
Controls on nitrogen export to an ephemeral stream network of St. Croix, US Virgin Islands
Authors: Lancellotti Brittany V. , Hensley David A. 
Published: January 2025

AbstractEphemeral streams are important pollutant conduits, but the mechanisms that control nutrient transport to these systems remain unclear. In the US Virgin Islands (USVI), where most streams flow ephemerally, a lack of continuous hydrologic and water quality data limits our understanding of streamflow behavior and its influence on water quality. We therefore assessed the impact of soil moisture and hydrometeorological conditions on nitrogen (N) concentrations within an ephemeral stream on St. Croix, USVI. Stream N concentrations were usually highest during initial flow events, after prolonged dryness, and declined thereafter. Nitrogen increased with shallow antecedent soil moisture and rainfall intensity and decreased with deep soil moisture and baseflow emergence, indicating it was predominantly exported to the stream via surface runoff, as opposed to subsurface leaching. Our results are the first of their kind for the USVI and could be used to improve water quality of freshwater and marine systems.
Calcineurin‐inhibitor induced pain syndrome due to interaction with clarithromycin: A case report
Authors: Inaba Satoshi , Okumura Hisatoshi , Aoki Tatsuya , Kawashima Atsushi 
Published: January 2025

AbstractCalcineurin inhibitor‐induced pain syndrome (CIPS) is a rare but serious condition characterized by severe lower leg pain, often associated with elevated tacrolimus (TAC) levels. We report the case of a 57‐year‐old woman with rheumatoid arthritis (RA) who developed CIPS following a drug interaction between TAC and clarithromycin (CAM), a common macrolide antibiotic. Discontinuation of TAC led to a rapid resolution of symptoms. This case highlights the importance of monitoring TAC levels and being cautious of drug interactions, especially in primary care settings, to prevent adverse events like CIPS.
The structure and implementation of practice‐integrated foundational professional development programs for hospital pharmacists: a scoping review
Authors: Sim Yu Ting , Kumar Saravana , Marotti Sally , Murray Carolyn 
Published: January 2025

AbstractBackgroundPractice‐integrated residency programs are one of the most recognised training platforms for early career development across settings, including hospital pharmacy. They embed a structured education and competency framework and preceptor mentoring systems in the workplace.AimThis review aimed to map the global literature on practice‐integrated education and professional development programs for early career hospital pharmacists, with a focus on how the programs were implemented and structured.DesignA search was applied to electronic databases MEDLINE, Ovid Emcare, Embase, ERIC, Scopus, PsycINFO, Cochrane Library, Google Scholar and grey literature sources until 31 December 2023. Search terms were developed in consultation with an academic librarian and using the population, concept and context mnemonic. The scoping review was conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses extension for Scoping Reviews and the Joanna Briggs Institute scoping review manual.ResultsForty‐seven papers were included from seven countries, with the majority (n = 33) being from the United States of America. Residency program details were mapped against jurisdictions and associated assessment processes, competency training areas, and focused training elements. Findings report similarities and differences of structural, competency frameworks, and locally driven context and requirements.ConclusionThe demand from early career pharmacists for residency programs remains high, with professional pharmacy organisations providing leadership to grow training positions. The global pharmacy development goals appear to be embedded within the residency programs, but gaps include training in non‐direct patient care competencies and research that demonstrates the outcomes from residency training.
Consumer perceptions of ‘traditional doenjang’ using a free word association test
Authors: Hwang Ji‐sun , Kim Mina K. 
Published: January 2025

AbstractBackgroundDoenjang (fermented soybean paste) is a traditional Korean ingredient that has long been part of Korean cuisine. Commercial, mass‐produced doenjang products are prevalent in the Korean market, and consumer demand for traditionally produced doenjang is steadily decreasing. An understanding of consumers' perceptions of traditional doenjang can serve as a foundation for sales and marketing strategies that are informed by consumer insights. The objective of the current study was to determine consumers' perception of traditional doenjang using a free word association test.ResultsA total of 339 participants responded to the survey, each carefully recruited from a predetermined demographic quota. A total of 906 valid words were elicited, representing 2.67 words per person, and these were categorized into six dimensions and 11 sub‐categories. Significant differences according to residential area were observed in four dimensions: ‘sensory,’ ‘foods,’ ‘health’ and ‘fermentation.’ Overall, the sensory dimension was the most dominant psychological concept relating to traditional doenjang among all consumers.ConclusionConsumers' sensory perceptions of traditional doenjang were mostly flavor‐related under sensory dimension such as ‘gu‐soo flavor,’ a well‐aged, and well‐fermented flavor. There was a difference in the perceptions of traditional doenjang according to age and residential area. © 2025 Society of Chemical Industry.