bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of proximate composition, amino acids, minerals and phytochemical profile of Cassava (Manihot esculenta) peel from sweet cassava variety grown in Yobe State of North Eastern Nigeria
Authors: Amaza I. B. 
Published: February 2021

The proximate composition, amino acid, mineral, and Phytochemical content of Cassava peel was determined. The peels were found to contain 8.70 % moisture, 4.89 % crude protein,
8.75 % crude fiber, 2.15 % crude fat, 8.93 % ash. Nitrogen free extract and metabolizable energy values were 66.56 % and 2717.96kcal, respectively. The results of amino acid content revealed that the histidine and tyrosine are the most limiting amino acid with values of 0.005% each. Essential amino acids such as lysine, leucine, methionine and Isoleucine with values of 0.032, 0.067, 0.076 and 0.070% were low. Mineral profile revealed that magnesium (913.74mg/kg) and iron (111.50mg/kg) as the most abundant mineral. Concentrations of phytochemicals were 26.06, 699.8, 0.063, 24.81,8.37,1457mg/100g and 2.84 for saponin, tannin, hydrogen cyanide, phytate, trypsin inhibitors, alkaloid and oxalate respectively. Based on results of this study, cassava peel can be potential source of energy; however, protein and amino acids contents are very low. It is therefore, recommended that feeding of animal with cassava peel based diets be supplemented with good quality amino acids.

La composition immédiate, l'acide aminé, la teneur minérale et phytochimique de la peau de manioc ont été déterminées. Les pelures contenaient 8,70 % d'humidité, 4,89 % de protéines brutes, 8,75 % de fibres brutes, 2,15 % de matières grasses brutes, 8,93 % de cendres. L'extrait sans azote et les valeurs énergétiques métabolisables étaient respectivement de 66,56 % et 2 717,96 kcal. Les résultats de la teneur en acides aminés ont révélé que l'histidine et la tyrosine sont l'acide aminé le plus limitant avec des valeurs de 0,005% chacune. Les acides aminés essentiels tels que la lysine, la leucine, la méthionine et l'isoleucine avec des valeurs de 0,032, 0,067, 0,076 et 0,070% étaient faibles. Le profil minéral a indiqué que le magnésium (913.74mg/kg) et le fer (111.50mg/kg) sont des minéraux les plus abondants. Les concentrations de produits phytochimiques étaient de 26,06, 699,8, 0,063, 24,81,8,37,1457mg/100g et 2,84 pour la saponine, le tanin, le cyanure d'hydrogène, le phytate, les inhibiteurs de la trypsine, l'alcaloïde et l'oxalate respectivement. D'après les résultats de cette étude, la peau de manioc peut être une source potentielle d'énergie ; cependant, la teneur en protéines et en acides aminés est très faible. Il est donc recommandé que l'alimentation des animaux avec des régimes à base de pelures de manioc soit complétée par des acides aminés de bonne qualité.
PENGARUH PERBANDINGAN CDI BRT DAN CDI STANDART TERHADAP EMISI GAS BUANG DENGAN PERFORMA MESIN SUZUKI SATRIA F150 2012
Authors: Pratama Bagus Rizki 
Published: February 2021

Perkembangan Teknologi pada saat ini yang maju sangat pesat mendorong manusia untuk selalu menciptakan inovasi dan teknologi di bidang otomotif khususnya untuk kendaraan roda 2 ( motor ). Sistem pengapian contonya salah salah satu komponen yang maju sangat pesat pada jaman sekarang, karena sistem pengapian sangat berpengaruh pada motor untuk balap dan mendapakan unjuk kerja mesin lebih meningkat. Jaman dulu sistem pengapian menggunakan sistem konfensional yaitu platina, seiring berjalannya waktu sistem ini mulai tidak di jaman sekarang , pada pengguna motor baru saat ini apalagi dunia balap yang ada di indonesia mereka lebih sering menggunakan sistem pengapian CDI (capasitor discharger ignition) berawal dari sistem pengapian CDI AC (alternating current) hingga berkembang menjadi sistem pengapian DC (direct current).Dan sistem ini pun mempunyai banyak tipe seperti : Limiter , unlimiter dualbrand maupun progammable. Dan sistem pengapian ini akan di coba pada motor suzuki satria f150,untuk mengetetahui seberapa besar performa masin pada sistem pengapian CDI limiter dan Unlimiter. penelian ini berbentuk perbandingan antara Sistem pengapian limiter dan unlimiter dan hasil akan di tampilkan dengan tabel dan grafik.
Lived Experiences of Incarcerated Mothers
Authors: Villanueva Shella Marcela P. , Gayoles Lisa Anna M. 
Published: February 2021

This study aimed to establish the lived experiences of persons deprived of liberty at the Iloilo City District Jail-Female Dorm, particularly mothers, based on their lived experiences as incarcerated mothers. It utilized the phenomenological research design. Common themes that emerged from the lived experiences of seven incarcerated mothers were drugs as reason for incarceration; inability to perform parental duties; missing family members; financial and encouragement provider; physical absence; religious coping; emotion-focused coping; embracing positive attitude through spirituality; having a happy family by becoming a better person and mother; promising future; and learning from the “inside”. These common themes were grouped into five main themes namely: incarceration due to drugs, facing the challenges of motherhood while incarcerated, being strong emotionally and spiritually, maintaining a positive outlook, and being hopeful. The findings suggest implications for collaborative efforts in developing programs for the improvement and sustainability of the well-being of incarcerated women.
EFEKTIVITAS METODE CERDAS CERMAT CEPAT DAN TEPAT (C3T) DALAM MENINGKATKAN MOTIVASI BELAJAR FIKIH
Authors: Partono Partono 
Published: February 2021

Penelitian ini bertujuan untuk mengetahui efektivitas metode cerdas cermat cepat dan tanggap dalam meningkatkan motivasi belajar Fikih. Penelitian ini dilatarbelakangi oleh banyaknya siswa yang menganggap pembelajaran Fikih adalah suatu pembelajaran yang membosankan dan itu itu saja. hal ini menyebabkan kejenuhan belajar siswa hingga berakibat rendahnya motivasi belajar Fikih. Rumusan masalah pada penelitian ini adalah bagaimana efektivitas metode cerdas cermat cepat, dan tanggap (C3T) dalam meningkatkan motivasi belajar Fikih di MI Hikmatun Najah, Penelitian ini merupakan jenis penelitian diskriptf kualitatif dan yang menjadi populasinya adalah MI Hikmatun Najah yang berada di kecamatan Japah Blora. Sedangkan sampel dalam penelitian ini diambil menggunakan teknik “rondom sampling” dimana yang diambil menjadi sampel adalah siswa yang berada di MI Hikmatun Najah yang mengunakan metode konvesional untuk menjadi kelas control dan salah satunya lagi di kelas yang menggunakan metode cerdas cermat cepat dan tanggap guna sebagai kelas eksperimen. kemudian data dianalisis dengan teknik analisis kualitatif. Berdasarkan hasil penelitian menunjukan bahwa metode cerdas cermat cepat dan tanggap sangat efektif karena terdapat kenaikan motivasi belajar pada mata pelajaran Fikih
Collaboration, culture and communication: Preparing the next generation to provide rural primary health care
Authors: Thomas Tami L. , Caldera Michelle , Glymph Derrick 
Published: February 2021

Background and objective: In an ever-changing landscape of health care needs and demands, the ability to provide care for rural communities is often overwhelming. Rural health care in a new decade demands targeted programs to improve recruitment, training, and sustained employment of primary care providers. This project served to address rural primary healthcare needs by the development of a project model to recruit, train, educate and evaluate Advanced Practice Registered Nurse students (APRN) students who were rigorously selected for a rural traineeship and practiced in rural counties. The evaluation of preceptors was also done to assist in retention and increased numbers of rural preceptors and clinical sites. This program was designed collaboratively and implemented with rural community partners and rural healthcare leaders.Methods: Graduate nursing students completed both a paper application and in person interviews to be selected for a rigorous 16-week clinical traineeship in the rural communities. Qualitative data were collected during interview and feedback sessions during their traineeship. Quantitative Data were collected on Process and Outcome Measures focused on learning objectives during their rural traineeship. These data were analyzed and evaluated to measure the effectiveness of program goals, outcomes, and sustainability of the program. Results and conclusions: The results support the structured process for selecting graduate students and with an innovative program design focused on rural culture and accessing resources for patients in these same rural areas. Both students and preceptors had improved performance and satisfaction over time. The results provide a road map to recreate programs with high clinical impact and increasing numbers of rural healthcare providers. Current follow-up data with APRN post program completion demonstrated increase in employment within rural areas post-graduation.
Epidemiological and Clinical Profile of Healthcare Providers Affected With Covid-19 at Civil Hospital; Medicity Campus; Ahmedabad; Gujarat
Authors: Parmar Kartikeya G , Parekh Dhaval V , Nogas Jinal , Aroor Bhagyalaxmi , , Raval Devang , Solanki Rajesh 
Published: February 2021

Background: SARS-CoV-2 has spread globally at a rapid pace, causing significant morbidity and mortality. Healthcare providers are especially vulnerable to infection with important implications. There might be adverse effects on their health, they could transmit the infection to vulnerable patients, family contacts and other staff if not quickly isolated and high rates of infection could cause problems due to health system manpower shortage.
Methodology: A cross-sectional study was conducted where a preformed semi-structured questionnaire was sent using Google forms. A total of 311 healthcare providers were sent the form out of which 161 responded. Analysis was done using Microsoft Excel 2019 and Google Forms.
Result: 75.16% healthcare providers always wore PPE, 11.18% wore it as per duty requirements and 13.66% used mask and sanitizer in non Covid duty areas. They were infected even with use of protective measures. 14.91% reported having co morbidities. Hypertension 8.7% followed by Diabetes 4.96% was the commonest. A significant association was present between sex and work profile of respondents with hospital admission.
Conclusion: Our study data can be used for making appropriate management strategies. Training should be provided in infection prevention control practices. Duty schedule should be designed so as to evenly distribute duties.
Družinska medicina v Sloveniji
Authors: Švab Igor , Klemenc-Ketiš Zalika , Poplas Susič Tonka , Rotar Pavlič Danica , Petek Šter Marija , Kolšek Marko , Gorup Eva Cedilnik 
Published: February 2021

Osnovna zdravstvena dejavnost in z njo družinska medicina predstavljata temelj vsakega zdravstvenega sistema. V Sloveniji imamo sistem osnovne zdravstvene dejavnosti, ki je konceptualno priznan kot zelo dober s strani mednarodnih strokovnjakov in organizacij. Ob tem se soočamo z resnimi kritikami in težavami. Prispevek predstavlja pregled izzivov, s katerimi se sooča družinska medicina v Sloveniji zdaj. V devetih točkah so zbrani predlogi ukrepov, ki bi jih bilo potrebno izpolniti, če želimo, da se stanje na področju družinske medicine izboljša.
Zdravljenje bruksizma, mialgij in hipertrofij masetrnih mišic z botulinskim toksinom tipa A
Authors: Vesnaver Aleš , Troha Aleš 
Published: February 2021

Izhodišče: Bruksizem (nočno škripanje in stiskanje z zobmi) je trdovraten problem, ki lahko prizadene več organskih sistemov. Povzroča obrabo sklenine in poškodbe zob ter protetičnih konstrukcij, bolečo hipertrofijo masetrnih mišic zaradi stalnega preobremenjevanja, včasih tudi bolečine v temporo-mandibularnih sklepih (TMS) in glavobol. Zdravljenje z injekcijami botulinskega toksina v mišico naj bi odpravilo ali omililo simptome.
Metode: Opravili smo retrospektivno analizo obdobja 2007–2018, v katerem smo z vbrizgavanjem botulinskega toksina zdravili 72 oseb z bruksizmom, mialgijami in hipertrofijami masetrnih mišic. Za raziskavo smo uspeli pridobiti podatke o razultatih zdravljenja za 64 bolnikov.
Rezultati: Velika večina (58 od 64 oz. 91 %) je poročala o izboljšanju stanja; bolečnost se je zmanjšala ali izginila, prav tako nočno škripanje, masetrne mišice so vidno uplahnile in se zmehčale. Učinek botulina sicer traja 4–6 mesecev, a sm 29 (50 %) bolnikih trajno odpravili simptome, zato se niso več vračali na preglede.
Zaključek: Oslabitev masetrnih mišic z vbrizgavanjem botulinskega toksina je učinkovito in varno zdravljenje, ki za več mesecev oslabi mišice, kar odpravi ali močno zmanjša simptome. Po potrebi se zdravljenje lahko večkrat ponovi.
With support, children can accurately sequence within‐event components
Authors: Price Heather L. , Evans Angela D. 
Published: February 2021

SummaryAccurate event sequencing can add critical detail to a child's account. However, our knowledge of sequencing in childhood to date primarily centers on distinct events separated by time. Sequencing a single event's components is also important, perhaps particularly in a forensic context. In two experiments, we explored children's ability to recall the sequence of a past event using a variety of prompts. In Experiment 1, 124 children (6–8 years) and Experiment 2, 96 children (6–8 years) attended a 45‐min workshop with four (Exp. 1) or five (Exp. 2) distinct components. Children were asked to sequence the components using different retrieval strategies (Exp. 1 within‐subjects; Exp. 2 between‐subjects). Children had difficulty reporting within‐event sequential order in response to open‐ended prompts but with sufficient visual supports, children were able to provide accurate information about the sequencing of within‐event components.
Acute patient‐reported outcomes in B‐cell malignancies treated with axicabtagene ciloleucel
Authors: Hoogland Aasha I. , Jayani Reena V. , Collier Aaron , Irizarry‐Arroyo Nathaly , Rodriguez Yvelise , Jain Michael D. , Booth‐Jones Margaret , Hyland Kelly A. , James Brian W. , Barata Anna , Bachmeier Christina A. , Chavez Julio C. , Khimani Farhad , Krivenko Gabriel S. , Lazaryan Aleksandr , Liu Hien D. , Nishihori Taiga , Pinilla‐Ibarz Javier , Shah Bijal D. , Abidi Muneer , Locke Frederick L. , Jim Heather S. L. 
Published: February 2021

AbstractChimeric antigen receptor T‐cell therapy with axicabtagene ciloleucel (axi‐cel) has considerably improved survival in adults with relapsed/refractory large B‐cell lymphoma. This study reports patient‐reported outcomes (PROs) such as quality of life (QOL) and toxicity in the first 90 days after treatment. Hematologic cancer patients treated with axi‐cel (N = 103, mean age = 61, 39% female) completed SF‐36 or PROMIS‐29 QOL questionnaires prior to treatment and 90 days after. PRO‐Common Terminology Criteria for Adverse Events toxicity items were completed by patients at baseline and 14, 30, 60, and 90 days after treatment. Mixed models examined change in PROs over time. From preinfusion to 90 days later, patients reported improvements in physical functioning, pain, and fatigue (ps < 0.01), but worsening of anxiety (p = 0.02). Patient‐reported toxicities worsened by day 14 with improvement thereafter. The five most severe symptoms at day 14 included fatigue, decreased appetite, dry mouth, diarrhea frequency, and problems with concentration. Results indicate improvement in some domains of QOL over time with transient patient‐reported toxicities.
Methylation status and long‐fragment cell‐free DNA are prognostic biomarkers for gastric cancer
Authors: Ko Kazuhide , Kananazawa Yoshikazu , Yamada Takeshi , Kakinuma Daisuke , Matsuno Kunihiko , Ando Fumihiko , Kuriyama Sho , Matsuda Akihisa , Yoshida Hiroshi 
Published: February 2021

AbstractBackgroundCirculating tumor DNA (ctDNA) detected before surgery disappears after complete surgical resection of the cancer. Residual ctDNA indicates minimal residual disease (MRD), which is a cause of recurrence. The presence of long‐fragment circulating cell‐free DNA (cfDNA) or methylated cfDNA also implies the presence of cancer. In this study, we evaluated the prognostic value of cfDNA methylation and long‐fragment cfDNA concentration in gastric cancer patients undergoing curative surgeryMethodsNinety‐nine gastric cancer patients were included. Peripheral blood samples were collected before and 1 month after surgery. In patients administered chemotherapy, samples were collected before starting chemotherapy. qPCR was performed to detect long‐ and short‐fragment LINE‐1. A plasma HELP (HpaII tiny fragment Enrichment by Ligation‐mediated PCR) assay to determine the concentration of HpaII small fragments was performed using ligation‐mediated PCR and HpaII was quantified as the HpaII:MspI ratio to detect methylation levels of cfDNA.ResultsOverall survival (OS) of patients with low methylation levels before starting treatment was significantly worse than that of patients with high methylation levels (P = 0.006). In the 90 patients who underwent curative surgery, recurrence‐free survival (RFS) and OS of patients with low methylation levels before surgery were worse than those with high methylation levels (P=0.08 and P = 0.11, respectively). RFS and OS of patients with high concentrations of long‐fragment LINE‐1 after surgery were significantly worse than those with low concentrations of long‐fragment LINE‐1 (P = 0.009, P = 0.04).ConclusionsPre‐surgical low methylation levels of LINE‐1 are a negative prognostic factor. Post‐surgical high concentrations of long‐fragment LINE‐1 indicate MRD and a high risk of recurrence.
Coordination Insertion Mechanism of Ring‐Opening Polymerization of Lactide Catalyzed by Stannous Octoate†
Authors: Rao Weihan , Cai Caiyun , Tang Jingyu , Wei Yiman , Gao Caiyun , Yu Lin , Ding Jiandong 
Published: February 2021

Main observation and conclusionRing‐opening polymerization (ROP) of cyclic esters in the presence of stannous octoate (Sn(Oct)2) is the main way to obtain biodegradable aliphatic polyesters, an important family of biodegradable polymers which have been widely used and still rapidly developed in the fields of biomedical polymers and environment‐friendly materials. The underlying mechanism is thought via a coordination‐insertion way, but the pathway is still open owing to the absence of direct experimental evidence. Herein, we inquire this issue through density functional theory (DFT) calculations. According to our DFT calculations and the following Curtin‐Hammett evaluation, the carbonyl oxygen has a significant advantage over the ester oxygen, and thus the ring is opened mainly through pathway A instead of pathway B. The stannous octoate is identified as a catalyst rather than an initiator. We eventually summarize the main stages during the whole polymerization of lactide.
The myosin regulatory light chain Myl5 localizes to mitotic spindle poles and is required for proper cell division
Authors: Ramirez Ivan , Gholkar Ankur A. , Velasquez Erick F. , Guo Xiao , Tofig Bobby , Damoiseaux Robert , Torres Jorge Z. 
Published: February 2021

AbstractMyosins are ATP‐dependent actin‐based molecular motors critical for diverse cellular processes like intracellular trafficking, cell motility, and cell invasion. During cell division, myosin MYO10 is important for proper mitotic spindle assembly, the anchoring of the spindle to the cortex, and positioning of the spindle to the cell mid‐plane. However, myosins are regulated by myosin regulatory light chains (RLCs), and whether RLCs are important for cell division has remained unexplored. Here, we have determined that the previously uncharacterized myosin RLC Myl5 associates with the mitotic spindle and is required for cell division. We show that Myl5 localizes to the leading edge and filopodia during interphase and to mitotic spindle poles and spindle microtubules during early mitosis. Importantly, depletion of Myl5 led to defects in mitotic spindle assembly, chromosome congression, and chromosome segregation and to a slower transition through mitosis. Furthermore, Myl5 bound to MYO10 in vitro and co‐localized with MYO10 at the spindle poles. These results suggest that Myl5 is important for cell division and that it may be performing its function through MYO10.
Photodynamic sensitizers modulate cytoskeleton structural dynamics in neuronal cells
Authors: Dubey Tushar , Chinnathambi Subashchandrabose 
Published: February 2021

AbstractThe neuronal cytoskeleton plays a crucial role in maintaining cell integrity and functioning of neurons. Cytoskeleton deformities have been reported to be associated with neurodegenerative diseases thus; cytoskeleton can be targeted for therapeutic strategies. The therapeutic application of photosensitive molecule is termed as photodynamic therapy (PDT). PDT has been applied in the field of dermatology, cancer biology, and antimicrobial therapy. PDT induces several changes in cells, which include induction of apoptosis, DNA damage, and induction of inflammatory response. PDT has been also reported to modulate cytoskeleton such as actin dynamics. The in vitro studies suggested that PDT using dyes such as Toluidine Blue and Rose Bengal effectively modulated the actin cytoskeleton, neurite outgrowth, tubulin, and Tau aggregation. In this review, we focused on the effect of photosensitized molecules on various cytoskeleton proteins. We hypothesize that PDT could have potency against Alzheimer's disease and other neurodegenerative disorders.
Systematic Review and Patient‐Level Meta‐Analysis of SARS‐CoV‐2 Viral Dynamics to Model Response to Antiviral Therapies
Authors: Gastine Silke , Pang Juanita , Boshier Florencia A.T. , Carter Simon J. , Lonsdale Dagan O. , Cortina‐Borja Mario , Hung Ivan F.N. , Breuer Judy , Kloprogge Frank , Standing Joseph F. 
Published: February 2021

Severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) viral loads change rapidly following symptom onset, so to assess antivirals it is important to understand the natural history and patient factors influencing this. We undertook an individual patient‐level meta‐analysis of SARS‐CoV‐2 viral dynamics in humans to describe viral dynamics and estimate the effects of antivirals used to date. This systematic review identified case reports, case series, and clinical trial data from publications between January 1, 2020, and May 31, 2020, following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. A multivariable Cox proportional hazards (Cox‐PH) regression model of time to viral clearance was fitted to respiratory and stool samples. A simplified four parameter nonlinear mixed‐effects (NLME) model was fitted to viral load trajectories in all sampling sites and covariate modeling of respiratory viral dynamics was performed to quantify time‐dependent drug effects. Patient‐level data from 645 individuals (age 1 month to 100 years) with 6,316 viral loads were extracted. Model‐based simulations of viral load trajectories in samples from the upper and lower respiratory tract, stool, blood, urine, ocular secretions, and breast milk were generated. Cox‐PH modeling showed longer time to viral clearance in older patients, men, and those with more severe disease. Remdesivir was associated with faster viral clearance (adjusted hazard ratio (AHR) = 9.19, P < 0.001), as well as interferon, particularly when combined with ribavirin (AHR = 2.2, P = 0.015; AHR = 6.04, P = 0.006). Combination therapy should be further investigated. A viral dynamic dataset and NLME model for designing and analyzing antiviral trials has been established.