bluuebunny/crossref_metadata_2025_split huggingface dataset:
Un proyecto educativo común: La relación familia y escuela. Revisión de investigaciones y normativas
Authors: Ceballos López Noelia , Saiz Linares Ángela 
Published: March 2021

Este trabajo tiene como foco de indagación los procesos de participación familiar en las escuelas de educación infantil y primaria. Para ello, se ha realizado una revisión bibliográfica y normativa bajo un diseño de carácter cualitativo de revisión sistemática de la literatura (análisis de contenido). De dicho análisis emerge una cartografía de la relación familia-escuela en torno a tres ejes: los procesos de enseñanza-aprendizaje, la atención a la diversidad; y la participación de las familias en la organización y gestión de la escuela. Finalmente, enunciamos algunas reflexiones que buscan contribuir a la reflexión sobre la relación familia-escuela y encaminar significados y actuaciones comprometidas con los objetivos inclusivos y democráticos.
This study aims to explore the processes of family participation in infant and primary schools. For this purpose, we conducted a bibliographic and normative systematic review which adopted a qualitative design based on the analysis of content. From this analysis, a cartography of the family-school relationship emerges around three pillars: teaching-learning processes, diversity and education, and participation of families in the school organization and management. Finally, we formulate some conclusions that seek to contribute to the reflection on the family-school relationship and to highlight meanings and actions which follow inclusive and democratic principles.
Resigned Activism
Authors: Lora-Wainwright Anna 
Published: March 2021

An examination of the daily grind of living with pollution in rural China and of the varying forms of activism that develop in response.
Residents of rapidly industrializing rural areas in China live with pollution every day. Villagers drink obviously tainted water and breathe visibly dirty air, afflicted by a variety of ailments—from arthritis to nosebleeds—that they ascribe to the effects of industrial pollution. In Resigned Activism, Anna Lora-Wainwright explores the daily grind of living with pollution in rural China and the varying forms of activism that develop in response. This revised edition offers expanded acknowledgment of the contributions of Lora-Wainwright's collaborators in China.
Lora-Wainwright finds that claims of health or environmental damage are politically sensitive, and that efforts to seek redress are frustrated by limited access to scientific evidence, growing socioeconomic inequalities, and complex local realities. Villagers, feeling powerless, often come to accept pollution as part of the environment; their activism is tempered by their resignation. Drawing on fieldwork done with teams of collaborators, Lora-Wainwright offers three case studies of “resigned activism” in rural China, examining the experiences of villagers who live with the effects of phosphorous mining and fertilizer production, lead and zinc mining, and electronic waste processing. The book also includes extended summaries of the in-depth research carried out by Ajiang Chen and his team in some of China's “cancer villages,” village-sized clusters of high cancer incidence. These cases make clear the staggering human costs of development and the deeply uneven distribution of costs and benefits that underlie China's economic power.
Genes for degradation and utilization of uronic acid-containing polysaccharides of a marine bacteriumCatenovulumsp. CCB-QB4
Authors: Furusawa Go , Azami Nor Azura , Teh Aik-Hong 
Published: March 2021

BackgroundOligosaccharides from polysaccharides containing uronic acids are known to have many useful bioactivities. Thus, polysaccharide lyases (PLs) and glycoside hydrolases (GHs) involved in producing the oligosaccharides have attracted interest in both medical and industrial settings. The numerous polysaccharide lyases and glycoside hydrolases involved in producing the oligosaccharides were isolated from soil and marine microorganisms. Our previous report demonstrated that an agar-degrading bacterium,Catenovulumsp. CCB-QB4, isolated from a coastal area of Penang, Malaysia, possessed 183 glycoside hydrolases and 43 polysaccharide lyases in the genome. We expected that the strain might degrade and use uronic acid-containing polysaccharides as a carbon source, indicating that the strain has a potential for a source of novel genes for degrading the polysaccharides.MethodsTo confirm the expectation, the QB4 cells were cultured in artificial seawater media with uronic acid-containing polysaccharides, namely alginate, pectin (and saturated galacturonate), ulvan, and gellan gum, and the growth was observed. The genes involved in degradation and utilization of uronic acid-containing polysaccharides were explored in the QB4 genome using CAZy analysis and BlastP analysis.ResultsThe QB4 cells were capable of using these polysaccharides as a carbon source, and especially, the cells exhibited a robust growth in the presence of alginate. 28 PLs and 22 GHs related to the degradation of these polysaccharides were found in the QB4 genome based on the CAZy database. Eleven polysaccharide lyases and 16 glycoside hydrolases contained lipobox motif, indicating that these enzymes play an important role in degrading the polysaccharides. Fourteen of 28 polysaccharide lyases were classified into ulvan lyase, and the QB4 genome possessed the most abundant ulvan lyase genes in the CAZy database. Besides, genes involved in uronic acid metabolisms were also present in the genome. These results were consistent with the cell growth. In the pectin metabolic pathway, the strain had genes for three different pathways. However, the growth experiment using saturated galacturonate exhibited that the strain can only use the pathway related to unsaturated galacturonate.
Ações a partir do PROEXT/MEC na UFSC: Impactos das oficinas em escolas públicas, indígenas e quilombolas na ampliação do acesso à Universidade Pública
Authors: De Melo Clarissa Rocha , Costa Maria Octavia Nóbrega 
Published: March 2021

<p><span>Este artigo produto de uma pesquisa de pós-doutorado desenvolvida por Melo, que contou com apoio da graduanda Nóbrega Costa, em iniciação científica. Apresentamos aqui a avaliação de oficinas realizadas em comunidades indígenas, quilombolas e em escolas da rede pública do entorno de Florianópolis, desenvolvidas no âmbito do PROEXT/MEC/SECADI, de 2012 a 2015.. Destarte, o presente artigo pretende trazer um panorama dos resultados dessas oficinas, partindo de uma contextualização pelas demandas das Ações Afirmativas na Universidade Federal de Santa Catarina em direção a reflexões sobre como esses programas de extensão contribuíram para o contexto atual de inclusão de acadêmicos indígenas, quilombolas e da rede pública nesta Universidade.. Finalmente, apontamos para importância da extensão universitária como um pilar básico para todas as ciências, sendo produtora de relações e de redes distintas. É nesse caminho da Antropologia em extensão que se pode pensar em uma Antropologia interessada politicamente com os sujeitos que ela estuda, “comprometida”, apoiando-se, ainda, na indissociabilidade entre ensino-pesquisa-extensão.</span></p>
Antibodies to neutralising epitopes synergistically block the interaction of the receptor‐binding domain of SARS‐CoV‐2 to ACE 2
Authors: Pandey Manisha , Ozberk Victoria , Eskandari Sharareh , Shalash Ahmed O , Joyce Michael A , Saffran Holly A , Day Christopher J , Lepletier Ailin , Spillings Belinda L , Mills Jamie‐Lee , Calcutt Ainslie , Fan Fan , Williams James T , Stanisic Danielle I , Hattingh Laetitia , Gerrard John , Skwarczynski Mariusz , Mak Johnson , Jennings Michael P , Toth Istvan , Tyrrell D Lorne , Good Michael F 
Published: March 2021

AbstractObjectivesA major COVID‐19 vaccine strategy is to induce antibodies that prevent interaction between the Spike protein's receptor‐binding domain (RBD) and angiotensin‐converting enzyme 2 (ACE2). These vaccines will also induce T‐cell responses. However, concerns were raised that aberrant vaccine‐induced immune responses may exacerbate disease. We aimed to identify minimal epitopes on the RBD that would induce antibody responses that block the interaction of the RBD and ACE2 as a strategy leading to an effective vaccine with reduced risk of inducing immunopathology.MethodsWe procured a series of overlapping 20‐amino acid peptides spanning the RBD and asked which were recognised by plasma from COVID‐19 convalescent patients. Identified epitopes were conjugated to diphtheria‐toxoid and used to vaccinate mice. Immune sera were tested for binding to the RBD and for their ability to block the interaction of the RBD and ACE2.ResultsSeven putative vaccine epitopes were identified. Memory B‐cells (MBCs) specific for one of the epitopes were identified in the blood of convalescent patients. When used to vaccinate mice, six induced antibodies that bound recRBD and three induced antibodies that could partially block the interaction of the RBD and ACE2. However, when the sera were combined in pairs, we observed significantly enhanced inhibition of binding of RBD to ACE2. Two of the peptides were located in the main regions of the RBD known to contact ACE2. Of significant importance to vaccine development, two of the peptides were in regions that are invariant in the UK and South African strains.ConclusionCOVID‐19 convalescent patients have SARS‐CoV‐2‐specific antibodies and MBCs, the specificities of which can be defined with short peptides. Epitope‐specific antibodies synergistically block RBD–ACE2 interaction.
A Collaborative and Supplemental Model to Enhance Early Language and Reading Skills
Authors: Nguyen Neal Nghia , Darling Sharon , Peralta Claudia , Mosier William , Garnett William 
Published: March 2021

AbstractThis department highlights language learning for bi/multilingual students worldwide, from our earliest learners to early adolescent writers. It also highlights exemplary teachers and ways that they include research‐based instruction to develop bi/multilingual learners.
Surprise, Surprise! Exploring Dust Jackets, Case Covers, and Endpapers in Picture Books to Support Comprehension
Authors: McNair Jonda C. 
Published: March 2021

AbstractI present a sampling of picture books with a focus on three peritextual features in particular: dust jackets, case covers that are different from the dust jackets, and endpapers. First, I briefly highlight scholarship related to peritextual features, followed by a description of four picture books with these three peritextual features, and explanations about how these features can support meaning making in regard to literary elements such as characterization, theme, plot, and setting. I conclude with the need to focus greater attention on peritextual features in picture books.
Functional 4-D clustering for characterizing intratumor heterogeneity in dynamic imaging: evaluation in FDG PET as a prognostic biomarker for breast cancer
Authors: Chitalia Rhea , Viswanath Varsha , Pantel Austin R. , Peterson Lanell M. , Gastounioti Aimilia , Cohen Eric A. , Muzi Mark , Karp Joel , Mankoff David A. , Kontos Despina 
Published: March 2021

AbstractPurposeProbe-based dynamic (4-D) imaging modalities capture breast intratumor heterogeneity both spatially and kinetically. Characterizing heterogeneity through tumor sub-populations with distinct functional behavior may elucidate tumor biology to improve targeted therapy specificity and enable precision clinical decision making.MethodsWe propose an unsupervised clustering algorithm for 4-D imaging that integrates Markov-Random Field (MRF) image segmentation with time-series analysis to characterize kinetic intratumor heterogeneity. We applied this to dynamic FDG PET scans by identifying distinct time-activity curve (TAC) profiles with spatial proximity constraints. We first evaluated algorithm performance using simulated dynamic data. We then applied our algorithm to a dataset of 50 women with locally advanced breast cancer imaged by dynamic FDG PET prior to treatment and followed to monitor for disease recurrence. A functional tumor heterogeneity (FTH) signature was then extracted from functionally distinct sub-regions within each tumor. Cross-validated time-to-event analysis was performed to assess the prognostic value of FTH signatures compared to established histopathological and kinetic prognostic markers.ResultsAdding FTH signatures to a baseline model of known predictors of disease recurrence and established FDG PET uptake and kinetic markers improved the concordance statistic (C-statistic) from 0.59 to 0.74 (p = 0.005). Unsupervised hierarchical clustering of the FTH signatures identified two significant (p < 0.001) phenotypes of tumor heterogeneity corresponding to high and low FTH. Distributions of FDG flux, or Ki, were significantly different (p = 0.04) across the two phenotypes.ConclusionsOur findings suggest that imaging markers of FTH add independent value beyond standard PET imaging metrics in predicting recurrence-free survival in breast cancer and thus merit further study.
Pharmacokinetics of UGN-101, a mitomycin-containing reverse thermal gel instilled via retrograde catheter for the treatment of low-grade upper tract urothelial carcinoma
Authors: Shabsigh Ahmad , Kleinmann Nir , Smith Angela B. , Scherr Douglas , Seltzer Elyse , Schoenberg Mark , Lerner Seth P. 
Published: March 2021

Abstract
Purpose
To evaluate the pharmacokinetic properties of UGN-101, a mitomycin-containing reverse thermal gel used as primary chemoablative treatment for low-grade upper tract urothelial carcinoma (UTUC), in a subset of patients participating in a phase 3 clinical trial.

Methods
Pharmacokinetic parameters (Cmax, Tmax, AUC(0–6), λz, t½, and AUCinf) were evaluated in six participants (male or female, ≥ 18 years) with biopsy-proven, low-grade UTUC who received the first of 6 once-weekly instillations of UGN-101 to the renal pelvis and calyces via retrograde ureteral catheter. Plasma samples were collected prior to instillation and 30 min, 1, 2, 3, 4, 5, and 6 h post-instillation. Safety was assessed by laboratory evaluations, physical exam, and adverse event monitoring.

Results
The mean age of the six participants was 69 years; most were male (5/6) and Caucasian (5/6). Mean (SD) Cmax was 6.24 (4.11) ng/mL and mean Tmax was 1.79 (1.89) hours after instillation. Mean apparent t½ following instillation was 1.27 (0.63) hours. Mean total systemic exposure to mitomycin up to 6 h post-instillation was 20.30 (19.69) ng h/mL. At 6 h post-instillation, mitomycin plasma concentrations of 5/6 participants were < 2 ng/mL. There were no clinically important adverse events or changes in laboratory values in any participant after a single instillation of UGN-101.

Conclusion
The reverse thermal gel formulation of UGN-101 is associated with higher concentration and extended dwell time of mitomycin in contact with the urothelium of the upper urinary tract while limiting systemic absorption of mitomycin.

Registration
NCT02793128; registered June 8, 2016.
Efficiency evaluation in data envelopment analysis using strong defining hyperplanes
Authors: Dellnitz Andreas , Reucher Elmar , Kleine Andreas 
Published: March 2021

AbstractCross-efficiency analysis in DEA generally uses a two-stage procedure: first, optimize a DMU’s individual efficiency score; next, push the efficiencies of all DMUs in a desired direction. In order to reduce subjective judgement in the second step, we provide a cross-efficiency method using only strong defining hyperplanes of the underlying technology. We develop a new DEA-based algorithm, and prove its finiteness and correctness. To reduce the computational burden, we show how one can combine the procedure with a known beneath-and-beyond procedure. Numerical investigations—comprising real-world data—demonstrate the superiority of the new method.
Accuracy of ultrasonography for differentiating between simple and complex appendicitis in children
Authors: Nijssen David J. , van Amstel Paul , van Schuppen Joost , Eeftinck Schattenkerk Laurens D. , Gorter Ramon R. , Bakx Roel 
Published: March 2021

Abstract
Purpose
Accurate differentiation between simple and complex appendicitis is important since differences in treatment exist. This study aimed to assess the accuracy of ultrasonography in differentiating between simple and complex appendicitis.

Methods
Data from children aged < 18 years who underwent appendectomy between the 1st of January 2013 and the 1st of January 2018 were analyzed retrospectively. Ultrasonography reports of eligible children were divided into simple (test negative) and complex appendicitis (test positive) based on predefined criteria and compared to a gold standard (a combination of predefined perioperative and histopathological criteria). Sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV) were calculated to measure ultrasonographic accuracy in differentiating between simple and complex appendicitis.

Results
176 children were eligible for inclusion. The mean age at the time of operation was 10.1 ± SD 4.6 years. 84 (47.7%) children had simple appendicitis and 92 (52.3%) had complex appendicitis. The use of ultrasonography yielded a sensitivity: 46%, specificity: 90%, PPV: 84%, and NPV: 60%.

Conclusion
Ultrasonography as standalone modality is not suitable for differentiating between simple and complex appendicitis in children. To improve preoperative differentiation, other variables such as clinical signs and laboratory data are necessary in conjunction with ultrasonography findings.
Is justice grounded? How expertise shapes conceptual representation of institutional concepts
Authors: Villani Caterina , D’Ascenzo Stefania , Borghi Anna M. , Roversi Corrado , Benassi Mariagrazia , Lugli Luisa 
Published: March 2021

AbstractUsing abstract concepts is a hallmark of human cognition. While multiple kinds of abstract concepts exist, they so far have been conceived as a unitary kind in opposition to concrete ones. Here, we focus on Institutional concepts, like justice or norm, investigating their fine-grained differences with respect to other kinds of abstract and concrete concepts, and exploring whether their representation varies according to individual proficiency. Specifically, we asked experts and non-experts in the legal field to evaluate four kinds of concepts (i.e., institutional, theoretical, food, artefact) on 16 dimensions: abstractness-concreteness; imageability; contextual availability; familiarity; age of acquisition; modality of acquisition; social valence; social metacognition; arousal; valence; interoception; metacognition; perceptual modality strength; body-object interaction; mouth and hand involvement. Results showed that Institutional concepts rely more than other categories on linguistic/social and inner experiences and are primarily characterized by positive valence. In addition, a more subtle characterization of the institutional domain emerged: Pure-institutional concepts (e.g., parliament) were perceived as more similar to technical tools, while Meta-institutional concepts (e.g., validity) were characterized mainly by abstract components. Importantly, for what concerns individual proficiency, we found that the level of expertise affects conceptual representation. Only law-experts associated Institutional concepts with exteroceptive and emotional experiences, showing also a more grounded and situated representation of the two types of institutional concepts. Overall, our finding highlights the richness and flexibility of abstract concepts and suggests that they differ in the degree of embodiment and grounding. Implications of the results for current theories of conceptual representation and social institutions are discussed.
Cancer patients’ perspective on shared decision-making and decision aids in oncology
Authors: Josfeld Lena , Keinki Christian , Pammer Carolina , Zomorodbakhsch Bijan , Hübner Jutta 
Published: March 2021

Abstract
Purpose
Shared Decision-Making (SDM) enhances patients’ satisfaction with a decision, which in turn increases compliance with and adherence to cancer treatment. SDM requires a good patient-clinician relationship and communication, patients need information matching their individual needs, and clinicians need support on how to best involve the individual patient in the decision-making process. This survey assessed oncological patients’ information needs and satisfaction, their preferred information in patient decision aids (PDAs), and their preferred way of making decisions regarding their treatment.

Methods
Questionnaires were distributed among attendees of a lecture program on complementary and alternative medicine in oncology of which 220 oncological patients participated.

Results
Participants reported a generally high need for information—correlating with level of education—but also felt overwhelmed by the amount. The latter proved particularly important during consultation. Use of PDAs increased satisfaction with given information but occurred in less than a third of the cases. Most requested contents for PDAs were pros and cons of treatment options and lists of questions to ask. The vast majority of patients preferred SDM to deciding alone. None wanted their physician to decide for them.

Conclusions
There is a high demand for SDM but a lack of conclusive evidence on the specific information needs of different types of patients. Conversation between patients and clinicians needs encouragement and support. PDAs are designed for this purpose and have the potential to increase patient satisfaction. Their scarce use in consultations calls for easier access to and better information on PDAs for clinicians.
C-reactive protein in spinal surgery: more predictive than prehistoric
Authors: Hoeller S. , Roch P. J. , Weiser L. , Hubert J. , Lehmann W. , Saul D. 
Published: March 2021

AbstractPurposeIn spinal surgery, surgical site infections (SSI) after dorsal spondylodesis lead to severe short- and long-term complications. Despite various clinical and serological evidence, the detection of a postoperative SSI remains crucial. In this retrospective cohort study, we determined the prognostic value of C-reactive protein (CRP) kinetics after open reduction and dorsal spondylodesis in the development of a SSI.MethodsWe retrospectively analyzed 192 patients from 2016 to 2018 undergoing open reduction and dorsal spondylodesis with and without SSI for 20 days at a level-I trauma center and assessed their serological and clinical characteristics.ResultsOn day 7 and 8 after surgery, patients who developed a SSI displayed significantly higher CRP levels. A second peak after the initial maximum of CRP and a restricted failure to decline as well as a maximum CRP of more than 225 mg/l predict an infectious complication with a sensitivity of 92.9%, and a specificity of 78.2%. A binary logistic regression leads to 85.7% and 69.7%, respectively. A one-phase decay exponential regression can predict 75.6% of the variance after the initial peak of CRP.ConclusionOur study demonstrates a high value of postoperative CRP kinetics in SSI detection after dorsal spondylodesis. Moreover, we observed typical CRP levels with a specific course as indicative predictors that may facilitate an early SSI detection in clinical practice.