bluuebunny/crossref_metadata_2025_split huggingface dataset:
A retrospective cohort study of 27,049 polytraumatized patients age 60 and above: identifying changes over 16 years
Authors: Kalbas Y. , Lempert M. , Ziegenhain F. , Scherer J. , Neuhaus V. , Lefering R. , Teuben M. , Sprengel K. , Pape H. C. , Jensen Kai Oliver ,   The TraumaRegister DGU
Published: July 2021

Abstract
Purpose
The number of severely injured patients exceeding the age of 60 has shown a steep increase within the last decades. These patients present with numerous co-morbidities, polypharmacy, and increased frailty requiring an adjusted treatment approach. In this study, we establish an overview of changes we observed in demographics of older severe trauma patients from 2002 to 2017.

Methods
A descriptive analysis of the data from the TraumaRegister DGU® (TR-DGU) was performed. Patients admitted to a level one trauma center in Germany, Austria and Switzerland between 2002 and 2017, aged 60 years or older and with an injury severity score (ISS) over 15 were included. Patients were stratified into subgroups based on the admission: 2002–2005 (1), 2006–2009 (2), 2010–2013 (3) and 2014–2017 (4). Trauma and patient characteristics, diagnostics, treatment and outcome were compared.

Results
In total 27,049 patients with an average age of 73.9 years met the inclusion criteria. The majority were males (64%), and the mean ISS was 27.4. The proportion of patients 60 years or older [(23% (1) to 40% (4)] rose considerably over time. Trauma mechanisms changed over time and more specifically low falls (< 3 m) rose from 17.6% (1) to 40.1% (4). Altered injury patterns were also identified. Length-of-stay decreased from 28.9 (1) to 19.5 days (4) and the length-of-stay on ICU decreased from 17.1 (1) to 12.7 days (4). Mortality decreased from 40.5% (1) to 31.8% (4).

Conclusion
Length of stay and mortality decreased despite an increase in patient age. We ascribe this observation mainly to increased use of diagnostic tools, improved treatment algorithms, and the implementation of specialized trauma centers for older patients allowing interdisciplinary care.
Physics of Dynamic Stall Vortex During Pitching Oscillation of Dynamic Airfoil
Authors: Wei Binbin , Gao Yongwei , Li Dong 
Published: July 2021

AbstractDynamic stall, which has a significant effect on the aerodynamic performances of dynamic airfoils, is closely related to the physics of the dynamic stall vortex (DSV). The physics of the DSV on the NACA 0012 airfoil was experimentally studied using unsteady pressure measurements with high time accuracy. The experimental Reynolds number was Re = 1.5 × 106, and the reduced frequency was k = 0.069. The propagation of the unsteady pressure field during the dynamic stall process was analyzed in detail. The motion characteristics of the DSV were examined, including its near-wall development characteristics and near-wall evolution velocity. Moreover, the frequency characteristics of the near-wall DSV were studied using wavelet analysis combined with proper orthogonal decomposition (POD) technology. In addition, the effects of the mean angle of attack (AoA) and the amplitude on the DSV motion and frequency characteristics were examined in detail. The effects of the mean AoA on the near-wall DSV strength and the propagation velocity were linear, while the effects of amplitude were nonlinear. The mean AoA and amplitude had a significant influence on the frequency of the leading-edge vortex (LEV) at the initial stage of the DSV development (x/c = 0.10–0.20). This work allows the DSV physics to be understood more deeply.
Graphic abstract
Subpial Thorn-shaped Astrocytes Are Prevalent In Guam ALS/PDC
Authors: Kovacs G.G. , Robinson J.L. , Perl D.P. , Lee V.M.Y. , Trojanowski J.Q. 
Published: July 2021

Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex is a progressive neurodegenerative disorder characterized by neuronal and glial tau pathologies. With the aim to evaluate aging-related tau astrogliopathy (ARTAG) we examined the collection at the University of Pennsylvania, consisting of blocks of the frontal parietal, temporal, and occipital cortices. Formalin fixed, paraffin-embedded tissue blocks were evaluated using anti-tau antibodies PHF-1 and AT8. In addition to neuronal and oligodendroglial tau pathology, granular/fuzzy astrocytes in the gray matter and thorn-shaped astrocytes (TSAs) in subpial location were also observed. Twenty-one out of 33 cases (63%) showed subpial TSAs diffusely along the cortical surface in one or more cortical regions. Accumulation of TSAs in the depth of the sulci were seen in 41% in the temporal, 7% in the frontal and 14% in parietal cortex. This was not associated with perivascular neuronal tau pathology in the depth of the sulci. Accumulation of TSAs in the depth of cortical sulci in this cohort is approximately 20 times more frequent than reported in a European aging cohort. The presence of subpial TSAs in the depth of cortical sulci in CTE and Guam PDC, and less frequently in aging brains, might suggest common mechanisms.Learning ObjectivesDescribe the spectrum of neuropathology in Guam ALS/PDCDescribe the frequency of tau positive cortical subpial thorn-shaped astrocytes
Effects of dietary tryptophan on muscle growth, protein synthesis and antioxidant capacity in hybrid catfish Pelteobagrus vachelli♀ × Leiocassis longirostris♂
Authors: Jiang Qin , Zhao Ye , Zhou Xiao-Qiu , Wu Xiao-Yun , Xu Shang-Xiao , Feng Lin , Liu Yang , Jiang Wei-Dan , Wu Pei , Zhao Juan , Jiang Jun 
Published: July 2021

AbstractThe present study evaluated effects of dietary supplementation with tryptophan (Trp) on muscle growth, protein synthesis and antioxidant capacity in hybrid catfish Pelteobagrus vachelli♀ × Leiocassis longirostris♂. Fish were fed six different diets containing 2·6 (control), 3·1, 3·7, 4·2, 4·7 and 5·6 g Trp/kg diet for 56 d, respectively. Results showed that dietary Trp significantly (1) improved muscle protein content, fibre density and frequency of fibre diameter; (2) up-regulated the mRNA levels of PCNA, myf5, MyoD1, MyoG, MRF4, IGF-I, IGF-II, IGF-IR, PIK3Ca, TOR, 4EBP1 and S6K1; (3) increased phosphorylation levels of AKT, TOR and S6K1; (4) decreased contents of MDA and PC, and increased activities of CAT, GST, GR, ASA and AHR; (5) up-regulated mRNA levels of CuZnSOD, CAT, GST, GPx, GCLC and Nrf2, and decreased Keap1 mRNA level; (6) increased nuclear Nrf2 protein level and the intranuclear antioxidant response element-binding ability, and reduced Keap1 protein level. These results indicated that dietary Trp improved muscle growth, protein synthesis as well as antioxidant capacity, which might be partly related to myogenic regulatory factors, IGF/PIK3Ca/AKT/TOR and Keap1/Nrf2 signalling pathways. Finally, based on the quadratic regression analysis of muscle protein and MDA contents, the optimal Trp requirements of hybrid catfish (21·82–39·64 g) were estimated to be 3·94 and 3·93 g Trp/kg diet (9·57 and 9·54 g/kg of dietary protein), respectively.
The perspectives of successful ageing among older adults aged 75+: a systematic review with a narrative synthesis of mixed studies
Authors: Badache Andreea C. , Hachem Hany , Mäki-Torkko Elina 
Published: July 2021

AbstractOlder adults 75 and above are a fast-growing segment of the population. However, few studies have investigated what it means to age successfully from their perspective. This group of older adults face challenges that might characteristically differ from younger older adults. Therefore, the aim of this study was to conduct a systematic review of the perspectives of older adults aged 75 and above regarding what it means to age successfully and to summarise the findings through a narrative synthesis. We also aimed to provide a snapshot of inhibitors and facilitators to achieve successful ageing. A systematic review of the 75+ older adults’ perspectives was conducted across PubMed, CINAHL, Scopus, Web of Science and PsycINFO. Qualitative, quantitative and mixed-methods original peer-reviewed studies were included. After reviewing 4,661 articles, 15 articles met the inclusion criteria and 15 themes were identified. They ranged from biomedical components such as physical functioning to psychosocial components such as relationships, reflections on life and past experiences, preparations for death and environmental factors. The findings revealed that as people age, their definition of successful ageing changes, expanding the current conceptualisation of successful ageing by including additional factors that can act as facilitators and/or inhibitors, such as death and environmental factors. The findings also highlight the need for further research on theory development by considering age-related differences and the perspectives of under-studied populations.
A lattice approach for option pricing under a regime-switching GARCH-jump model
Authors: Guo Zhiyu , Bai Yizhou 
Published: July 2021

AbstractIn this study, we consider option pricing under a Markov regime-switching GARCH-jump (RS-GARCH-jump) model. More specifically, we derive the risk neutral dynamics and propose a lattice algorithm to price European and American options in this framework. We also provide a method of parameter estimation in our RS-GARCH-jump setting using historical data on the underlying time series. To measure the pricing performance of the proposed algorithm, we investigate the convergence of the tree-based results to the true option values and show that this algorithm exhibits good convergence. By comparing the pricing results of RS-GARCH-jump model with regime-switching GARCH (RS-GARCH) model, GARCH-jump model, GARCH model, Black–Scholes (BS) model, and Regime-Switching (RS) model, we show that accommodating jump effect and regime switching substantially changes the option prices. The empirical results also show that the RS-GARCH-jump model performs well in explaining option prices and confirm the importance of allowing for both jump components and regime switching.
Potentially Inappropriate Medication Use in the Elderly
Authors: Charles Lesley , Kumar Elena , Elghol Eimad , Dobbs Bonnie , Tian Peter George Jaminal , Babenko Oksana 
Published: July 2021

AbstractIt is estimated that approximately half of adults, older than 65 years of age, have been prescribed potentially inappropriate medications (PIMs). This study’s objective was to determine the prevalence of PIM use among older patients. Two retrospective chart reviews were performed on 200 and 164 older patients who underwent comprehensive geriatric assessments (CGAs) at outpatient geriatrics clinics at the Glenrose Rehabilitation Hospital (Glenrose) in 2012–13 and at the Misericordia Community Hospital (Misericordia) in 2016–17, respectively. Outcome measures included demographics; prevalence of PIM use; common PIMs used; whether PIM use was addressed, and if so, how; and total number of oral medications. At the Glenrose, the prevalence of PIM use was 45 per cent (90/200). Of the 90 patients who had used PIMs, 46.7 per cent (42/90) had at least one of their medications stopped or modified. At the Misericordia, the prevalence of PIM use was 57.3 per cent (94/164). Of the 94 patients who used PIMs, 47.9 per cent (45/94) had at least one of their medications stopped or modified. These results suggest that an increased awareness of PIM among physicians is needed to further decrease PIM use.
Electrophysiological effects and clinical utility of propafenone in children
Authors: Singh Manavotam , McKenzie Keore , Hudak Mark L. , Gehi Anil K. , Ferns Sunita J. 
Published: July 2021

AbstractAim:This retrospective case series study sought to describe the safety and clinical effectiveness of propafenone for the control of arrhythmias in children with and without CHD or cardiomyopathy.Methods:We reviewed baseline characteristics and subsequent outcomes in a group of 63 children treated with propafenone at 2 sites over a 15-year period Therapy was considered effective if no clinically apparent breakthrough episodes of arrhythmias were noted on the medication.Results:Sixty-three patients (29 males) were initiated on propafenone at a median age of 2.3 years. CHD or cardiomyopathy was noted in 21/63 (33%). There were no significant differences between demographics, clinical backgrounds, antiarrhythmic details, side effect profiles, and outcomes between children with normal hearts and children with CHD or cardiomyopathy. Cardiac depression at the initiation of propafenone was more common amongst children with CHD or cardiomyopathy compared to children with normal hearts. Systemic ventricular function was diminished in 15/63 patients (24%) prior to starting propafenone and improved in 8/15 (53%) of patients once better rhythm control was achieved. Other than one child in whom medication was stopped due to gastroesophageal reflux, no other child experienced significant systemic or cardiac side effects during treatment with propafenone. Propafenone achieved nearly equal success in controlling arrhythmias in both children with normal hearts and children with congenital heart disease or cardiomyopathy (90% versus 86%, p = 0.88).Conclusion:Propafenone is a safe and effective antiarrhythmic medication in children.
Heterotaxy: fluctuat nec mergitur
Authors: Houyel Lucile , Moreau de Bellaing Anne , Bonnet Damien 
Published: July 2021

AbstractThe International Pediatric and Congenital Cardiac Code (IPCCC) states thatvisceral heterotaxyis defined as “a congenital malformation in which the internal thoraco-abdominal organs demonstrate abnormal arrangement across the left-right axis of the body. By convention, in congenital cardiology, heterotaxy syndrome does not include patients with complete mirror-imaged arrangement of the internal organs along the left-right axis also known as “total mirror imagery” or “situs inversus totalis”.” [www.ipccc.net]In patients with heterotaxy, it is important to describe both the cardiac relations and the junctional connections of the cardiac segments, with documentation of the arrangement of the atrial appendages, the ventricular topology, the nature of the unions of the segments across the atrioventricular and the ventriculoarterial junctions, the infundibular morphologies, and the relationships of the arterial trunks in space. Particular attention is required for the venoatrial connections, since these are so often abnormal. The relationship and arrangement of the remaining thoraco-abdominal organs, including the lungs, the spleen, the liver, and the intestines, also must be described separately, because, although common patterns of association have been identified, there are frequent exceptions to these common patterns. Therefore, in patients with heterotaxy, it is important to describe each thoracic and abdominal organ independently.
Stress tolerance indices for the identification of low phosphorus tolerant introgression lines derived from Oryza rufipogon Griff.
Authors: P. S. Basavaraj , C. Gireesh , Bharamappanavara Muralidhara , C. A. Manoj , V. G. Ishwarya Lakshmi , Honnappa  , V. Ajitha , P. Senguttuvel , R. M. Sundaram , M. S. Anantha 
Published: July 2021

AbstractSoil phosphorus (P) deficiency is one of the major challenges for the cultivation of rice worldwide because it limits the growth and productivity of the crop. Therefore, the ability to grow in P-deficit soils is an important trait for rice cultivation. O . rufipogon Griff., a wild relative of rice, is a source of genetic variation for low phosphorus tolerance. The present study was undertaken to identify low P stress-tolerant introgression lines by analysing stress tolerance indices of 40 introgression lines of O. rufipogon. The populations were screened under low soil P and normal soil P plots for two growing seasons. Based on yield under stress and normal conditions, we computed different stress indices, including stress tolerance index (STI), tolerance index, yield reduction ratio (YR), stress susceptibility index, yield stability index (YSI), yield index, per cent yield reduction and geometric mean productivity (GMP). The studies of correlation analysis, principal component analysis and clustering revealed that STI, YSI and GMP were ideal indices for the selection of genotypes that performed well under both stress and normal conditions. Based on these indices, introgression lines (IL-24, IL-29 and IL-32) were identified as promising low P tolerant lines, which exhibited better grain yield under both stress (YS) and normal (YP) conditions. These pre-breeding lines serve as valuable genetic resources for low P tolerance in rice breeding programmes across the world.
Sekolah Islam (Islamic Schools) as Symbols of Indonesia's Urban Muslim Identity
Authors: Pribadi Yanwar 
Published: July 2021

AbstractThis article discusses the relationship between Sekolah Islam (Salafism-influenced Islamic schools) and urban middle-class Muslims. Based on ethnographic fieldwork in the City of Serang (Kota Serang), near Jakarta, this paper argues that these conservative and puritan Muslims demonstrate their Islamic identity politics through their engagement with Sekolah Islam. The analysis of in-depth interviews with and close observations of parents of students and school custodians (preachers or occasionally spiritual trainers) at several Sekolah Islam reveals that they have attempted to pursue ‘true’ Islamic identity and have claimed recognition of their identity as the most appropriate. The pursuit of a ‘true’ Islamic identity has infused Islamic identity politics, and there is an oppositional relationship between local Islamic traditions and Salafism, as seen in Sekolah Islam. The relationship between Islam and identity politics becomes intricate when it is transformed into public symbols, discourses, and practices at many Sekolah Islam. This paper shows that through their understanding and activities at Sekolah Islam, these Muslims are avid actors in the contemporary landscape of Islamic identity politics in Indonesia. By taking examples from Sekolah Islam in Indonesia, this article unveils social transformations that may also take place in the larger Muslim world.
Challenge Demands and Resilience
Authors: Kunzelmann Arian , Rigotti Thomas 
Published: July 2021

Abstract. This study investigates the relationship of challenge demands (i. e., time pressure, job complexity) on employee resilience. We provide insights into potential pathways (i. e., learning, cognitive irritation) for how challenge stressors influence employee resilience. We employed a two-wave, time-lagged design to examine the influences of challenge stressors and explanatory pathways on employee resilience 2 months later. The data from 359 participants (52.1 % male) were analyzed using a Bayesian time-lagged path model. Results indicate that time pressure and job complexity are negatively related to employee resilience via cognitive irritation. In contrast, we found a positive, indirect effect of job complexity and resilience via learning. This paper contributes to existing employee resilience and stress research by highlighting the roles of learning and cognitive irritation to explain the relationships of challenge stressors on employee resilience. Moreover, the results provide us with a deeper understanding of which factors foster or drain employee resilience.
Periodic Variations in Solar Wind and Responses of the Magnetosphere and Thermosphere in March 2017
Authors: Zhang Yongliang , Paxton Larry , Wang Wenbin , Huang Chaosong 
Published: July 2021

AbstractTIMED/GUVI observed thermospheric column ∑O/N2 depletion in both hemispheres between March 1 and 21, 2017 which was caused by large periodic variations in interplanetary magnetic field (IMF) and a high solar wind speed, likely in a solar wind. The dominant periods seen in the solar wind and magnetosphere coupling function (CF) were around 1.9, 3.0, 4.7, 7.6, 14.0 and 22.0 h on March 1 and 2. The major AE variations were around 3.0, 4.7, 7.6, 10.7, 14.0 and 22.0 h. Auroral hemispheric power (HP) also showed periodic variations similar to that of AE, except for the absence of the 3.0 h variation due to a low sampling rate in HP data. SymH data didn't show the periodic variations seen in AE but a weak 12‐h periodic variation which was seen in the solar wind dynamic pressure. A weak AE and HP variation at 10.7‐h period was not observed in CF or any individual solar wind parameters or IMF components. These results suggest that (a) the oscillating IMF pumped energy and mass periodically into the magnetosphere and the polar ionosphere, creating a long lasting (20‐days) storm and O/N2 depletion, (b) the high latitude AE and HP responded to the solar wind and IMF variations directly, (c) SymH did not show any direct periodic responses, likely due to the fact that the ring current response resulted from the cumulative effect of solar wind and IMF drivers, (d) the 10.7‐h variations in AE and HP were likely due to magnetospheric internal processes.
Free Infragravity Waves in the North Sea
Authors: Rijnsdorp Dirk P. , Reniers Ad J. H. M. , Zijlema Marcel 
Published: July 2021

AbstractInfragravity waves are low‐frequency surface waves that can impact a variety of nearshore and oceanic processes. Recent measurements in the North Sea showed that significant bursts of infragravity energy occurred during storm events. Using a spectral wave model, we show that a substantial part of this energy was radiated from distant shorelines where it was generated by the incident sea‐swell waves. These radiated infragravity waves can cross the North Sea basin and reach distant shorelines. The origin of the infragravity wave energy varied between the different storms, and particularly depends on where largest sea‐swell waves made landfall. Along the coastlines of the North Sea, shoreward directed infragravity waves that originate from a remote source were non‐negligible during storm events. This suggests that radiated infragravity waves can potentially contribute to coastal dynamics and hazards away from their region of generation.
GEM Workshop on Intercalibrating Cusp Signatures
Authors: Anonymous  
Published: July 2021

On October 9, 1990, a lively group of more than 60 scientists from around the world gathered at Northeastern University's Henderson House in Weston, Mass., to spend 4 days in concentrated efforts to unravel the complexities of cusp/cleft theory and observations.Plans for the National Science Foundation‐sponsored workshop were formulated at the previous GEM workshop convened by Ted Rosenberg at the University of Maryland in October 1989, where participants agreed that the first task of the first GEM campaign—attacking problems of the magnetopause, boundary layers, and their signatures in the ionosphere—should be the identification of cusp signatures in ground‐based and airborne data by intercalibrating with spacecraft data on direct overflights.