bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revisiting the relationship between farm mechanization and labour requirement in India
Authors: Rajkhowa Pallavi , Kubik Zaneta 
Published: October 2021

AbstractIn many developing and emerging economies, better employment opportunities in the non-farm sector have increased rural wages due to labour shortages during the peak agricultural season. Increasing wages often cause a substitution of labour for mechanical power, but extensive use of labour-saving technologies may cause labour displacement and have serious equity concerns. Using the household and individual fixed effect estimation approach, this paper analyses the relationship between different types of farm machines and labour requirements in India. The results suggest that a unit increase in the level of farm mechanization increases the demand for hired labour by 12%. Moreover, we find that the level of farm mechanization has a positive effect on women’s participation in farm work, while it decreases the probability of children participating in agriculture-related work. Disaggregated analysis based on types of farm machinery suggests that water-lifting equipment, draft power and tractors increase the probability of male household members working on their farms, while all types of farm machines, except tractors, have a positive effect on female farm labour participation. We also find that the effect of farm mechanization on the demand for hired labour decreases as the size of the farm increases.
Online-to-offline advertisements as field experiments
Authors: Matsui Akira , Moriwaki Daisuke 
Published: October 2021

AbstractOnline advertisements have become one of today’s most widely used tools for enhancing businesses partly because of their compatibility with A/B testing. A/B testing allows sellers to find effective advertisement strategie,s such as ad creatives or segmentations. Even though several studies propose a technique to maximize the effect of an advertisement, there is insufficient comprehension of the customers’ offline shopping behavior invited by the online advertisements. Herein, we study the difference in offline behavior between customers who received online advertisements and regular customers (i.e., the customers visits the target shop voluntary), and the duration of this difference. We analyze approximately three thousand users’ offline behavior with their 23.5 million location records through 31 A/B testings. We first demonstrate the externality that customers with advertisements traverse larger areas than those without advertisements, and this spatial difference lasts several days after their shopping day. We then find a long-run effect of this externality of advertising that a certain portion of the customers invited to the offline shops revisit these shops. Finally, based on this revisit effect findings, we utilize a causal machine learning model to propose a marketing strategy to maximize the revisit ratio. Our results suggest that advertisements draw customers who have different behavior traits from regular customers. This study demonstrates that a simple analysis may underrate the effects of advertisements on businesses, and an analysis considering externality can attract potentially valuable customers.
Covid-19 as an opportunity to teach epistemic insight: findings from exploratory workshops on Covid-19 and science with students aged 15–17 in England
Authors: Billingsley Berry , Heyes Joshua M. , Nassaji Mehdi 
Published: October 2021

AbstractThe contributions of science and scientists to combatting Covid-19 have been at the forefront of media attention throughout 2020 and early 2021, exposing the public to the processes of science in an unprecedented manner. The pandemic has highlighted the necessity of scientists working collaboratively with other disciplines in informing thinking about a complex, evolving real-world problem. This draws attention to recent efforts, both in the UK and internationally, towards curriculum reform integrating epistemic insight (knowledge about knowledge, including about what disciplines are and how they interact), with significant implications for the teaching of science in schools. We present findings from two exploratory workshops with 15–17-year-old students in England on the role of science during the pandemic. We found that the workshops provided space for students to begin to develop epistemic insight regarding how science informs decision-making in dialogue with other disciplines. We make recommendations proposing pedagogical approaches using live, complex, real-world problems to address issues around understandings of the nature of science, misinformation, trust and participation in science.
Energy versus safety: unilateral action, voter welfare, and executive accountability
Authors: Noble Benjamin S. 
Published: October 2021

AbstractDoes increasing executive power necessarily decrease accountability? To answer this question, I develop a two-period signaling model comparing voter welfare in two separation-of-powers settings. In one, the executive works with a median legislator to change policy; in the other, the executive chooses between legislation or unilateral action. Both politicians may have preferences that diverge from the voter's, yet I find that increasing executive power may increase accountability and welfare, even in some cases when the legislator is more likely to share the voter's preferences than the executive. Unilateral power allows a congruent executive to overcome gridlock, implement the voter's preferred policy, and reveal information about the politicians’ types—which can outweigh the risks of a divergent executive wielding power for partisan ends.
EXPERIMENTS AT MODANE UNDERGROUND LABORATORY OR THE SWAN SONG OF RADIOCARBON ß-COUNTING BY GAS PROPORTIONAL COUNTER
Authors: Fontugne Michel , Hatté Christine , Jaudon Michel 
Published: October 2021

ABSTRACTIn 1991, a 14C ß-counting installation with four proportional CO2 gas counters was tested at the Modane underground laboratory, 1700 m below the summit of Pointe du Fréjus, reducing the muon flux to 4 muons per square meter and per day. With cosmic radiation attenuated by a factor of 2.106, the background level of the counters was reduced by 65 to 85% while its variability was reduced by a factor of 30–80 depending on the type of counter. The dating limit of these counters extends to well beyond 60,000 years.
Association of dietary inflammatory index and metabolic syndrome in the elderly over 55 years in Northern China
Authors: Li Ruiqiang , Zhan Wenqiang , Huang Xin , Zhang Zechen , Zhou Meiqi , Bao Wei , Li Qingxia , Ma Yuxia 
Published: October 2021

AbstractWe assessed the association between the dietary inflammatory index (DII) and the development of metabolic syndrome in the elderly over 55 years in Northern China. The data of 1936 Chinese adults aged 55 years and over from a community-based neurological disease cohort study from 2018 to 2019 were analysed. Multiple logistic regression and restricted cubic splines regression were used for analysis, and social demographics, lifestyle and health-related factors were adjusted. In the fully adjusted model, the risk of metabolic syndrome increased by 1·28-fold in people with a pro-inflammatory diet. When we divide the metabolic syndrome by its components, high pro-inflammatory diet and hyperglycaemia, TAG, hypertension and abdominal obesity, we failed to observe a significant association between a high pro-inflammatory diet and HDL-cholesterol. However, these associations are moving in the expected direction. At the same time, the results of BMI subgroup analysis showed that with the increase of DII, obese people are at increased risk of metabolic syndrome, hyperglycaemia, high TAG, hypertension and abdominal obesity. Also in overweight people, the increase in DII is accompanied by an increased risk of hyperglycaemia and abdominal obesity. Higher inflammatory diet is related to metabolic syndrome, hypertension, hyperglycaemia, abdominal obesity and hypertriglyceridaemia. Further research is needed to confirm the role of inflammation and diet in the development of metabolic syndrome; however, it is desirable to reduce the dietary components associated with inflammation.
Restrained eating behaviour, anorexia nervosa and food consumption between children and adolescents: a scoping review
Authors: Pereira Emile Miranda , da Silva Karine Brito Beck , Costa Priscila Ribas de Farias , da Silva Laís Eloy Machado , Nepomuceno Carina Márcia Magalhães , da Silva Helena Benes Matos , Santos Belfort Érika , Cunha Carla de Magalhães , de Santana Mônica Leila Portela 
Published: October 2021

AbstractAnorexia nervosa (AN) and restrained eating behaviour (REB) are characterised by reduced food intake to achieve body weight loss. This scope review aimed to describe the existing evidence on the association between AN, restrictive eating behaviour and food consumption. Studies with children and adolescents of both sexes of all races and ethnicities were included. Experimental and observational studies, systematic reviews, meta-analysis, case reports or series, conference abstracts, dissertations and theses were also included. The search was conducted in ten electronic databases and grey literature without language restriction on 14 November 2020. Twenty-four studies met the inclusion criteria. Most studies included girls and identified lower intake of energy content, fat and certain micronutrients. There was also a higher intake of caffeine, fibre, vegetables, legumes and fruits and a lower intake of low-quality snack, fast food, sweets and foods with high carbohydrate and fat contents. The need to improve the quality of the diet among study participants was also identified. Thus, it is recommended that the evaluation of food consumption be careful to develop effective prevention strategies for the development of AN/REB and minimise nutritional deficiencies in these individuals.
Baseball, Modernity, and Science Discourse in British Popular Culture, 1871–1883
Authors: Beaver Daniel C. 
Published: October 2021

AbstractBaseball in the United Kingdom has long been considered a contradiction in terms, especially during the nineteenth century, with both the 1874 National Association Tour and the 1888 Spalding Tour viewed as financial and cultural failures in a sophisticated consumer society already dominated by cricket. This article takes a fresh look at evidence from the 1870s and 1880s in order to challenge this perspective. It presents the 1874 Tour as a transnational success, articulating shared Anglo-American assumptions about modernity, science, and social progress. This discourse informed a broad process of technology transfer involving new sources of industrial power as well as the corporal techniques of modern sport. The article also places the tour in the context of a unique historical phenomenon: the transatlantic diffusion of an early modern English game to the United Kingdom as the New York Game, a modern American sport. Previous accounts of the tour focused on a few selected reports, confirming American views of its financial failings and British disinterest in its exhibitions. When considered in light of hundreds of British accounts from the 1870s, including unexamined evidence of the first British baseball clubs less than two years after the tour, this perspective becomes unsustainable.
Long-term mortality predictors of ICU fungaemia
Authors: Xie Peng , Wang Wenqiang , Dong Maolong 
Published: October 2021

Abstract
Bloodstream fungal infections have a high mortality rate. There is little data about the long-term mortality rate of fungaemia.This study aimed to explore the mortality of fungaemia and the influencing factors associated with death. In total, 204 intensive care unit (ICU) patients with fungaemia from Multi-parameter Intelligent Monitoring in Intensive Care-III (MIMIC-III) Database were studied. Age, gender, major underlying diseases, data about vital signs and blood test results were analysed to identify the predictors of the mortality and prognosis of fungaemia in ICU patients. Cox regression models were constructed, together with Kaplan−Meier survival curves. The 30-day, 1-year, 2-year, 3-year and 4-year mortality rates were 41.2%, 62.3%, 68.1%, 72.5% and 75%, respectively. Age (P ＜ 0.001, OR = 1.530; P ＜ 0.001, OR = 1.485)，serum bilirubin (P = 0.016, OR = 2.125；P = 0.001, OR = 1.748) and international normalised ratio (INR) (P = 0.001, OR = 2.642; P ＜ 0.001 OR = 2.065) were predictors of both the 30-day and 4-year mortality rates. Renal failure (P = 0.009, OR = 1.643) performed good in prediction of the 4-year mortality. The mortality of fungaemia is high. Age，the serum bilirubin and INR are good predictors of the 30-day and 4-year mortality rates of fungaemia. Renal failure has good performance in predicting the long-term mortality.
ABELIAN CYCLES IN THE HOMOLOGY OF THE TORELLI GROUP
Authors: Lindell Erik 
Published: October 2021

AbstractIn the early 1980s, Johnson defined a homomorphism
$\mathcal {I}_{g}^1\to \bigwedge ^3 H_1\left (S_{g},\mathbb {Z}\right )$
, where
$\mathcal {I}_{g}^1$
is the Torelli group of a closed, connected, and oriented surface of genus g with a boundary component and
$S_g$
is the corresponding surface without a boundary component. This is known as the Johnson homomorphism.We study the map induced by the Johnson homomorphism on rational homology groups and apply it to abelian cycles determined by disjoint bounding-pair maps, in order to compute a large quotient of
$H_n\left (\mathcal {I}_{g}^1,\mathbb {Q}\right )$
in the stable range. This also implies an analogous result for the stable rational homology of the Torelli group
$\mathcal {I}_{g,1}$
of a surface with a marked point instead of a boundary component. Further, we investigate how much of the image of this map is generated by images of such cycles and use this to prove that in the pointed case, they generate a proper subrepresentation of
$H_n\left (\mathcal {I}_{g,1}\right )$
for
$n\ge 2$
and g large enough.
AN APERIODIC TILE WITH EDGE-TO-EDGE ORIENTATIONAL MATCHING RULES
Authors: Walton James J. , Whittaker Michael F. 
Published: October 2021

AbstractWe present a single, connected tile which can tile the plane but only nonperiodically. The tile is hexagonal with edge markings, which impose simple rules as to how adjacent tiles are allowed to meet across edges. The first of these rules is a standard matching rule, that certain decorations match across edges. The second condition is a new type of matching rule, which allows tiles to meet only when certain decorations in a particular orientation are given the opposite charge. This forces the tiles to form a hierarchy of triangles, following a central idea of the Socolar–Taylor tilings. However, the new edge-to-edge orientational matching rule forces this structure in a very different way, which allows for a surprisingly simple proof of aperiodicity. We show that the hull of all tilings satisfying our rules is uniquely ergodic and that almost all tilings in the hull belong to a minimal core of tilings generated by substitution. Identifying tilings which are charge-flips of each other, these tilings are shown to have pure point dynamical spectrum and a regular model set structure.
Hepatocyte organoids and cell transplantation: What the future holds
Authors: Peng Weng Chuan , Kraaier Lianne J. , Kluiver Thomas A. 
Published: October 2021

AbstractHistorically, primary hepatocytes have been difficult to expand or maintain in vitro. In this review, we will focus on recent advances in establishing hepatocyte organoids and their potential applications in regenerative medicine. First, we provide a background on the renewal of hepatocytes in the homeostatic as well as the injured liver. Next, we describe strategies for establishing primary hepatocyte organoids derived from either adult or fetal liver based on insights from signaling pathways regulating hepatocyte renewal in vivo. The characteristics of these organoids will be described herein. Notably, hepatocyte organoids can adopt either a proliferative or a metabolic state, depending on the culture conditions. Furthermore, the metabolic gene expression profile can be modulated based on the principles that govern liver zonation. Finally, we discuss the suitability of cell replacement therapy to treat different types of liver diseases and the current state of cell transplantation of in vitro-expanded hepatocytes in mouse models. In addition, we provide insights into how the regenerative microenvironment in the injured host liver may facilitate donor hepatocyte repopulation. In summary, transplantation of in vitro-expanded hepatocytes holds great potential for large-scale clinical application to treat liver diseases.
Biobanking of human gut organoids for translational research
Authors: Perrone Francesca , Zilbauer Matthias 
Published: October 2021

AbstractThe development of human organoid culture models has led to unprecedented opportunities to generate self-organizing, three-dimensional miniature organs that closely mimic in vivo conditions. The ability to expand, culture, and bank such organoids now provide researchers with the opportunity to generate next-generation living biobanks, which will substantially contribute to translational research in a wide range of areas, including drug discovery and testing, regenerative medicine as well as the development of a personalized treatment approach. However, compared to traditional tissue repositories, the generation of a living organoid biobank requires a much higher level of coordination, additional resources, and scientific expertise. In this short review, we discuss the opportunities and challenges associated with the generation of a living organoid biobank. Focusing on human intestinal organoids, we highlight some of the key aspects that need to be considered and provide an outlook for future development in this exciting field.
Strategies for genetic manipulation of adult stem cell-derived organoids
Authors: Menche Constantin , Farin Henner F. 
Published: October 2021

AbstractOrganoid technology allows the expansion of primary epithelial cells from normal and diseased tissues, providing a unique model for human (patho)biology. In a three-dimensional environment, adult stem cells self-organize and differentiate to gain tissue-specific features. Accessibility to genetic manipulation enables the investigation of the molecular mechanisms underlying cell fate regulation, cell differentiation and cell interactions. In recent years, powerful methodologies using lentiviral transgenesis, CRISPR/Cas9 gene editing, and single-cell readouts have been developed to study gene function and carry out genetic screens in organoids. However, the multicellularity and dynamic nature of stem cell-derived organoids also present challenges for genetic experimentation. In this review, we focus on adult gastrointestinal organoids and summarize the state-of-the-art protocols for successful transgenesis. We provide an outlook on emerging genetic techniques that could further increase the applicability of organoids and enhance the potential of organoid-based techniques to deepen our understanding of gene function in tissue biology.
Dissecting single-cell genomes through the clonal organoid technique
Authors: Youk Jeonghwan , Kwon Hyun Woo , Kim Ryul , Ju Young Seok 
Published: October 2021

AbstractThe revolution in genome sequencing technologies has enabled the comprehensive detection of genomic variations in human cells, including inherited germline polymorphisms, de novo mutations, and postzygotic mutations. When these technologies are combined with techniques for isolating and expanding single-cell DNA, the landscape of somatic mosaicism in an individual body can be systematically revealed at a single-cell resolution. Here, we summarize three strategies (whole-genome amplification, microdissection of clonal patches in the tissue, and in vitro clonal expansion of single cells) that are currently applied for single-cell mutational analyses. Among these approaches, in vitro clonal expansion, particularly via adult stem cell-derived organoid culture technologies, yields the most sensitive and precise catalog of somatic mutations in single cells. Moreover, because it produces living mutant cells, downstream validation experiments and multiomics profiling are possible. Through the synergistic combination of organoid culture and genome sequencing, researchers can track genome changes at a single-cell resolution, which will lead to new discoveries that were previously impossible.
Growth differentiation factor-15 and the association between type 2 diabetes and liver fibrosis in NAFLD
Authors: Bilson Josh , Scorletti Eleonora , Bindels Laure B. , Afolabi Paul R. , Targher Giovanni , Calder Philip C. , Sethi Jaswinder K. , Byrne Christopher D. 
Published: October 2021

Abstract
Background
Type 2 diabetes mellitus (T2DM) is a strong risk factor for liver fibrosis in non-alcoholic fatty liver disease (NAFLD). It remains uncertain why T2DM increases the risk of liver fibrosis. It has been suggested that growth differentiation factor-15 (GDF-15) concentrations increase the risk of liver fibrosis. We aimed to investigate (a) whether GDF-15 concentrations were associated with liver fibrosis and involved in the relationship between T2DM and liver fibrosis and (b) what factors linked with T2DM are associated with increased GDF-15 concentrations.

Methods
Ninety-nine patients with NAFLD (61% men, 42.4% T2DM) were studied. Serum GDF-15 concentrations were measured by electro-chemiluminescence immunoassay. Vibration-controlled transient elastography (VCTE)-validated thresholds were used to assess liver fibrosis. Regression modelling, receiver operator characteristic curve analysis and Sobel test statistics were used to test associations, risk predictors and the involvement of GDF-15 in the relationship between T2DM and liver fibrosis, respectively.

Results
Patients with NAFLD and T2DM (n = 42) had higher serum GDF-15 concentrations [mean (SD): 1271.0 (902.1) vs. 640.3 (332.5) pg/ml, p < 0.0001], and a higher proportion had VCTE assessed ≥F2 fibrosis (48.8 vs. 23.2%, p = 0.01) than those without T2DM. GDF-15 was independently associated with liver fibrosis (p = 0.001), and GDF-15 was the most important single factor predicting ≥F2 or ≥F3 fibrosis (≥F2 fibrosis AUROC 0.75, (95% CI 0.63–0.86), p < 0.001, with sensitivity, specificity, positive predictive (PPV) and negative predictive (NPV) values of 56.3%, 86.9%, 69.2% and 79.1%, respectively). GDF-15 was involved in the association between T2DM and ≥F2 fibrosis (Sobel test statistic 2.90, p = 0.004). Other factors associated with T2DM explained 60% of the variance in GDF-15 concentrations (p < 0.0001). HbA1c concentrations alone explained 30% of the variance (p < 0.0001).

Conclusions
GDF-15 concentrations are a predictor of liver fibrosis and potentially involved in the association between T2DM and liver fibrosis in NAFLD. HbA1c concentrations explain a large proportion of the variance in GDF-15 concentrations.