bluuebunny/crossref_metadata_2025_split huggingface dataset:
Touch and Go: Fast Interprofessional Collaboration Relief
Authors: Doehler Steven , Goodin Jeanine 
Published: March 2021

Working collaboratively through interprofessional education is highly effective when solving problems in community health. Unlike in industry, academic collaborations are limited to class time and are often sporadic. This fragmentation often translates into teams not finding their stride until midsemester.The Design + Nursing Collaboration (D + NC) developed the "Touch and Go" collaboration method to address this lag. This method focuses on bringing students together early to unite under easily completed tasks via in‐person and distance collaboration. This method strategically brings designers and nurses together and then breaks them apart at appropriate moments to enable them to focus and excel in their area of specialty. The collaboration method allows students to come together and solve wicked problems as a large team. This method requires a diverse mindset, one that can see the broad view and address significant challenges from various perspectives. However, as the problems become more complex, disciplinary experts need to shine without compromise and break away and perform the tasks in their field of expertise.The authors will outline and demonstrate the process, the outcomes, and how "Touch and Go" moved the solution further faster.
Soluble programmed cell death protein 1 (sPD‐1) and the soluble programmed cell death ligands 1 and 2 (sPD‐L1 and sPD‐L2) in lymphoid malignancies
Authors: Mortensen Julie B. , Monrad Ida , Enemark Marie B. , Ludvigsen Maja , Kamper Peter , Bjerre Mette , d'Amore Francesco 
Published: March 2021

AbstractBackgroundThe programmed cell death protein 1 (PD‐1) and its ligand 1 and 2 (PD‐L1/PD‐L2) regulate the immune system, and the checkpoint pathway can be exploited by malignant cells to evade anti‐tumor immune response. Soluble forms (sPD‐1/sPD‐L1/sPD‐L2) exist in the peripheral blood, but their biological and clinical significance is unclear.MethodTime‐resolved immunofluorometric assay (TRIFMA) and enzyme‐linked immunosorbent assay (ELISA) were used to measure sPD‐1, sPD‐L1, and sPD‐L2 levels in serum from 131 lymphoma patients and 22 healthy individuals.ResultsPatients had higher sPD‐1 and sPD‐L2 levels than healthy individuals. In diffuse large B‐cell lymphoma, patients with high International Prognostic Index score had higher sPD‐1 levels and sPD‐L2 levels correlated with subtype according to cell of origin. Compared to other lymphoma types, follicular lymphoma displayed higher sPD‐1 and lower sPD‐L1 levels along with lower ligand/receptor ratios.ConclusionThis is the first study to simultaneously characterize pretherapeutic sPD‐1, sPD‐L1, and sPD‐L2 in a variety of lymphoma subtypes. The relation between higher sPD‐1 levels and adverse prognostic factors suggests a possible biological role and potential clinical usefulness of sPD‐1. Moreover, the reverse expression pattern in follicular lymphoma and T‐cell lymphoma/leukemia may reflect biological information relevant for immunotherapy targeting the PD‐1 pathway.
Cytokine gene polymorphisms are associated with response to blinatumomab in B‐cell acute lymphoblastic leukemia
Authors: Jeyakumar Nikeshan , Aldoss Ibrahim , Yang Dongyun , Mokhtari Sally , Gendzekhadze Ketevan , Khaled Samer , O'Donnell Margaret , Palmer Joycelynne , Song Joo Y. , Marcucci Guido , Stein Anthony S. , Forman Stephen J. , Pullarkat Vinod A. , Chen Wei , Wu Xiwei , Nakamura Ryotaro 
Published: March 2021

AbstractBlinatumomab is a bispecific T cell‐engaging antibody approved for treatment of relapsed/refractory (r/r) ALL, with 40%‐50% complete response (CR)/CR with incomplete count recovery (CRi). Cytokine release syndrome (CRS) as a major adverse effect after blinatumomab therapy. Here, we evaluated the possible association between single‐nucleotide polymorphisms (SNPs) in cytokine genes, disease response, and CRS in r/r ALL patients who received blinatumomab between 2012 and 2017 at our center (n = 66), using patients’ archived DNA samples. With a median duration of 9.5 months (range: 1‐37), 37 patients (56.1%) achieved CR/CRi, 54 (81.8%) experienced CRS (G1: n = 35, G2: n = 14, G3: n = 5), and 9 (13.6%) developed neurotoxicity. By multivariable analysis, after adjusting for high disease burden, one SNP on IL2 (rs2069762), odds ratio (OR) = 0.074 (95% CI: NE‐0.43, P = .01) and one SNP on IL17A (rs4711998), OR = 0.28 (95% CI: 0.078‐0.92, P = .034) were independently associated with CR/CRi. None of the analyzed SNPs were associated with CRS. To our knowledge, this is the first study demonstrating a possible association between treatment response to blinatumomab and SNPs. Our hypothesis‐generated data suggest a potential role for IL‐17 and IL‐2 in blinatumomab response and justify a larger confirmatory study, which may lead to personalized blinatumomab immunotherapy for B‐ALL.
Greater, but not necessarily better: The influence of biochar on soil hydraulic properties
Authors: Rabbi Sheikh M.F. , Minasny Budiman , Salami Shuaib T. , McBratney Alex. B. , Young Iain M. 
Published: March 2021

AbstractBiochar is recommended as a soil amendment for its positive influence on soil hydrological properties, which results in improved soil fertility and crop yield. Much research in the last decade has been conducted in field and laboratory conditions on the effect of biochar on the hydraulic properties of soil. However, reported results in the literature are substantially inconsistent. Here we performed a meta‐analysis to capture the variations in change in hydraulic properties of arable soils after application of different rates of biochar. The meta‐analysis revealed that high biochar rates (>50 t ha−1) compared to low rates (<20 t ha−1) significantly improved dry bulk density in sandy and clay soils, in field and laboratory experiments. However, field capacity only improved in laboratory experiments on sandy soils. The plant available water, permanent wilting point and saturated hydraulic conductivity did not significantly increase at high rates of biochar application compared to the low rates when applied to different types of soils in both field and laboratory experiments. We discuss possible reasons for this, including hydrophobicity of the biochar with future research directions. We concluded that the current evidence does not support the notion that the application of biochar improves soils' available water capacity.HighlightsMeta‐analysis clarifies the influence of biochar on soil hydraulic properties.Biochar addition at higher rates only improves the water holding capacity of sandy soils.Biochar types and pyrolysis temperatures do not influence soil hydraulic properties.The efficiency of biochar may depend on its pore size distribution and hydrophobicity.
Clinical characteristics and outcomes of thymoma‐associated myasthenia gravis
Authors: Álvarez‐Velasco Rodrigo , Gutiérrez‐Gutiérrez Gerardo , Trujillo Juan Carlos , Martínez Elisabeth , Segovia Sonia , Arribas‐Velasco Marina , Fernández Guillermo , Paradas Carmen , Vélez‐Gómez Beatriz , Casasnovas Carlos , Nedkova Velina , Guerrero‐Sola Antonio , Ramos‐Fransi Alba , Martínez‐Piñeiro Alicia , Pardo Julio , Sevilla Teresa , Gómez‐Caravaca María Teresa , López de Munain Adolfo , Jericó Ivonne , Pelayo‐Negro Ana L. , Martín María Asunción , Morgado Yolanda , Mendoza María Dolores , Pérez‐Pérez Helena , Rojas‐García Ricard , Turon‐Sans Janina , Querol Luis , Gallardo Eduard , Illa Isabel , Cortés‐Vicente Elena 
Published: March 2021

AbstractBackground and purposePrognosis of myasthenia gravis (MG) in patients with thymoma is not well established. Moreover, it is not clear whether thymoma recurrence or unresectable lesions entail a worse prognosis of MG.MethodsThis multicenter study was based on data from a Spanish neurologist‐driven MG registry. All patients were aged >18 years at onset and had anti‐acetylcholine receptor antibodies. We compared the clinical data of thymomatous and nonthymomatous patients. Prognosis of patients with recurrent or nonresectable thymomas was assessed.ResultsWe included 964 patients from 15 hospitals; 148 (15.4%) had thymoma‐associated MG. Median follow‐up time was 4.6 years. At onset, thymoma‐associated MG patients were younger (52.0 vs. 60.4 years, p < 0.001), had more generalized symptoms (odds ratio [OR]: 3.02, 95% confidence interval [CI]: 1.95–4.68, p < 0.001) and more severe clinical forms according to the Myasthenia Gravis Foundation of America (MGFA) scale (OR: 1.6, 95% CI: 1.15–2.21, p = 0.005). Disease severity based on MGFA postintervention status (MGFA‐PIS) was higher in thymomatous patients at 1 year, 5 years, and the end of follow‐up. Treatment refractoriness and mortality were also higher (OR: 2.28, 95% CI: 1.43–3.63, p = 0.001; hazard ratio: 2.46, 95% CI: 1.47–4.14, p = 0.001). Myasthenic symptoms worsened in 13 of 27 patients with recurrences, but differences in long‐term severity were not significant. Fifteen thymomatous patients had nonresectable thymomas with worse MGFA‐PIS and higher mortality at the end of follow‐up.ConclusionsThymoma‐associated MG patients had more severe myasthenic symptoms and worse prognosis. Thymoma recurrence was frequently associated with transient worsening of MG, but long‐term prognosis did not differ from nonrecurrent thymoma. Patients with nonresectable thymoma tended to present severe forms of MG.
A potential contribution of decreased serum galectin‐10 levels to systemic inflammation and pulmonary vascular involvement in systemic sclerosis
Authors: Awaji Kentaro , Miyagawa Takuya , Fukui Yuki , Toyama Satoshi , Omatsu Jun , Norimatsu Yuta , Ikawa Tetsuya , Watanabe Yusuke , Yoshizaki Ayumi , Sato Shinichi , Asano Yoshihide 
Published: March 2021

AbstractObjectiveGalectin‐10 (Gal‐10) is a key molecule involved in eosinophil‐mediated suppression of T‐cell immune response. Systemic sclerosis (SSc) is characterized by T helper (Th) 2/Th17 immune response and impaired function of regulatory T cells, but the pathological role of Gal‐10 has not been studied so far. Therefore, we investigated the clinical correlation of serum Gal‐10 levels in SSc patients.MethodsSerum Gal‐10 levels were determined by enzyme‐linked immunosorbent assay in 38 patients with diffuse cutaneous SSc (dcSSc), 30 with limited cutaneous SSc and 20 healthy controls. Clinical correlations of serum Gal‐10 levels were examined.ResultsSerum Gal‐10 levels were significantly lower in SSc patients than in healthy controls, especially in dcSSc patients, and inversely correlated with skin score, the percentage of predicted diffusion lung capacity for carbon monoxide and estimated right ventricular systolic pressure (RVSP). Furthermore, serum Gal‐10 levels had negative correlations with leucocyte counts and inflammatory parameters. Multivariate regression analysis identified C‐reactive protein and RVSP as explanatory parameters for serum Gal‐10 levels.ConclusionDecreased serum Gal‐10 levels may reflect the impairment of eosinophil‐mediated regulatory system for T‐cell immune response in SSc, possibly contributing to pulmonary vascular involvement leading to pulmonary arterial hypertension.
Mothering managers: (Re)interpreting older women's organizational subjectivity
Authors: Cutcher Leanne 
Published: March 2021

AbstractThis paper explores motherhood as an organizational subjectivity. Highlighting the experience of older women in a global engineering firm, and my own experience as an academic leader, the paper shows how the maternal body is culturally produced and how discourses of motherhood perpetuate highly gendered notions of who can give and receive care in organizations. This paper argues that the patriarchal construction of women as endlessly maternal, but never complete, limits the possibility for gendered agency. The paper calls for a reinterpretation of the maternal in organizations that would allow women to reclaim a feminine space where they can draw on the full repertoire of their embodied potentialities in order to experiment and assert their subjectivity. This reinterpretation of the maternal would also facilitate an uncoupling of notions of care and motherhood which would allow for a degendered reciprocal care offered and received by all members of the organization.
Painful nails: A practical approach to the diagnosis and management of painful nail conditions
Authors: Olvera‐Rodríguez Valeria , Gatica‐Torres Michelle , Carrillo‐Córdova Dulce María , Barrera‐Godínez Alejandro , Domínguez‐Cherit Judith 
Published: March 2021

AbstractBecause several nail disorders share similar clinical features, their diagnosis and management can be challenging to clinicians. The physical examination may disclose localized abnormalities or point to an underlying systemic disease, requiring additional workup. Furthermore, cosmetic distress and nail‐related symptoms (e.g., tingling, stinging, numbness, and pain) are common factors that influence the patient's search for medical assistance. Nail pain (i.e., onychalgia) can accompany both localized and systemic pathology. Onychalgia can be acute or chronic according to the time of evolution; patients may describe it as intermittent or constant, and as a throbbing, burning, sharp, or shooting sensation denoting the nature of the pain. It may be exacerbated by colder temperatures, touch, and increased activity (e.g., manipulating objects, walking). We present four main groups of conditions that might cause nail pain: nail tumors, nail deformities, inflammatory or infectious diseases, and external or traumatic agents. Our article includes an overview of the clinical features, as well as diagnosis and management pearls for each entity. Physicians (dermatologists and nondermatologists) should be aware that abnormalities of the ungual and subungual space are not exclusive of dermatological disorders but may also be present in noncutaneous contexts.
Does the open shop harm union collective action?
Authors: Zullo Roland 
Published: March 2021

AbstractIn the United States, right‐to‐work (RTW) laws impose the open shop on labour unions. I test whether RTW affects the frequency and outcomes of union representation petitions. Quasi‐experimental tests reveal no association between RTW law and the volume of certification petitions filed and that fewer certification petitions are withdrawn under RTW. Thus, unions do not appear to retreat from new member organizing under RTW law. Moreover, RTW correlates with a decline in decertification and unit clarification petitions, implying that under the open shop, RTW law reduces internal union dissension. Although fewer decertification cases go to an election under RTW law, unions are more likely to lose cases that proceed to a referendum. These changes benefit smaller more than larger bargaining units. I infer that the law nudges the system away from an industrial union model in favour of smaller, craft or occupation‐based units.
A criterion space search algorithm for mixed integer linear maximum multiplicative programs: a multiobjective optimization approach
Authors: Saghand Payman Ghasemi , Charkhgard Hadi 
Published: March 2021

AbstractWe study a class of mixed integer optimization problems with linear constraints and a multilinear objective function, the so‐called mixed integer linear maximum multiplicative programs (MIL‐MMPs). Such a problem can be transformed into a second‐order cone program (SOCP) and can be solved effectively by a commercial solver such as CPLEX. However, MIL‐MMPs can also be viewed as special cases of the problem of optimization over the set of efficient solutions in multiobjective optimization. Using this observation, we develop a criterion space search algorithm for solving any MIL‐MMP. An extensive computational study on around 2000 instances illustrates that the proposed algorithm significantly outperforms not only the CPLEX mixed integer SOCP solver but also a state‐of‐the‐art algorithm that is capable of solving special cases of MIL‐MMPs. Moreover, the computational study illustrates that even if we linearize the objective function and solve the linearized problem by CPLEX, the proposed algorithm still performs significantly better.
Alpha‐mangostin improves endothelial dysfunction in db/db mice through inhibition of aSMase/ceramide pathway
Authors: Jiang Meng , Huang Shanya , Duan Wang , Liu Qiaoshu , Lei Minxiang 
Published: March 2021

AbstractDiabetic vascular complications are the leading causes of death and disability in patients with diabetes. Alpha‐mangostin has been reported to have anti‐diabetic capacity in recent years. Here, we investigated the protective function of alpha‐mangostin on endothelium in vitro and in vivo experiments. We also observed that alpha‐mangostin improved impaired endothelium‐dependent vasodilation (EDV) of diabetic animals while it limited the aSMase/ceramide pathway and up‐regulated eNOS/NO pathway in aortas from diabetic mice. Meanwhile, alpha‐mangostin inhibited elevated aSMase/ceramide pathway and reversed impaired EDV induced by high glucose in isolated mouse aortas. In addition, alpha‐mangostin increased phosphorylation of eNOS and NO production in high glucose‐treated aortas. Alpha‐mangostin normalized high glucose‐induced activation of aSMase/ceramide pathway and improved eNOS/NO pathway in endothelial cells with high glucose. In conclusion, alpha‐mangostin regulates eNOS/NO pathway and improves EDV in aortas of diabetic mice through inhibiting aSMase activity and endogenous ceramide accumulation.
Two novel qualitative transcriptional signatures robustly applicable to non‐research‐oriented colorectal cancer samples with low‐quality RNA
Authors: Cheng Jun , Guo Yating , Guan Guoxian , Huang Haiyan , Jiang Fengle , He Jun , Wu Junling , Guo Zheng , Liu Xing , Ao Lu 
Published: March 2021

AbstractCurrently, due to the low quality of RNA caused by degradation or low abundance, the accuracy of gene expression measurements by transcriptome sequencing (RNA‐seq) is very challenging for non‐research‐oriented clinical samples, majority of which are preserved in hospitals or tissue banks worldwide with complete pathological information and follow‐up data. Molecular signatures consisting of several genes are rarely applied to such samples. To utilize these resources effectively, 45 stage II non‐research‐oriented samples which were formalin‐fixed paraffin‐embedded (FFPE) colorectal carcinoma samples (CRC) using RNA‐seq have been analysed. Our results showed that although gene expression measurements were significantly affected, most cancer features, based on the relative expression orderings (REOs) of gene pairs, were well preserved. We then developed two REO‐based signatures, which consisted of 136 gene pairs for early diagnosis of CRC, and 4500 gene pairs for predicting post‐surgery relapse risk of stage II and III CRC. The performance of our signatures, which included hundreds or thousands of gene pairs, was more robust for non‐research‐oriented clinical samples, compared to that of two published concise REO‐based signatures. In conclusion, REO‐based signatures with relatively more gene pairs could be robustly applied to non‐research‐oriented CRC samples.
Opportunity, Presence and Entrepreneurship: Why the EU Acts Externally on Higher Education*
Authors: Gerards Carsten , Schunz Simon , Damro Chad 
Published: March 2021

AbstractIn recent times, the European Union’s external engagement has expanded in originally internal policy areas. This process is particularly intriguing in areas where the EU possesses only supplementary competences. Examining the case of EU higher education policy, this contribution sets out to understand and explain EU external engagement in such areas. To this end, it employs an explanatory framework that argues that EU external action emerges when a structural policy window of external ‘opportunity’ and domestic ‘presence’ opens, which is exploited by ‘policy entrepreneurs’. The contribution compares two pillars of EU higher education policy – the Tempus and Erasmus Mundus programmes – which it sets in relation to the emergence of external action in other EU higher education initiatives. Offering an explanation of why the EU engages externally in higher education, the contribution concludes by discussing the broader generalizability of its findings.
The Oral Status Survey Tool: construction, validity, reliability and feasibility among people with mild and moderate intellectual disabilities
Authors: Mac Giolla Phadraig C. , Ishak N. S. , van Harten M. , Al Mutairi W. , Duane B. , Donnelly‐Swift E. , Nunn J. 
Published: March 2021

AbstractBackgroundA lack of robust data about the oral health of people with intellectual disabilities (IDs) contributes to health disparities. Appropriate research tools are therefore needed. This study reports the construction and evaluation of the Oral Status Survey Tool (OSST), designed to be administered with people with disabilities by non‐dental personnel.MethodOral Status Survey Tool construction and evaluation was achieved adopting a non‐clinical construction and content validation phase and a clinical phase to test concurrent validity, reliability and feasibility. Final refinements were also made.ResultsThe OSST conceptual framework covered oral function (tooth count, denture wear and opposing pairs of teeth) and oral disease/treatment need (soft tissue status, oral cleanliness, gum condition, carious teeth and oral pain). A systematic literature review identified no existing suitable indices. Candidate items were identified and validated by experts generating content validation ratios. This framework was modified later to expand the function construct. In the initial clinical phase, 49 out of 60 participants underwent examination with OSST and standard dental assessments. All had mild to moderate IDs. Mean age was 43 years (SD = 16), and mean number of teeth was 22.1 (SD = 8.6). Data collectors included two dentists and three non‐dentists. Later, a further 17 adults (nine female and eight male) with mild/moderate IDs were included for refinement. At this stage, data collectors included two dentists and five non‐dentists. Concurrent validity was established for tooth count [intraclass correlation coefficient = 0.99 (95% confidence interval, CI: 0.99–0.99)], carious teeth [Gwet's AC2 = 0.94 (95% CI: 0.89–0.99)] and gum condition [Gwet's AC1 = 0.84 (95% CI: 0.64–1)]. For all final OSST items, inter‐rater reliability ranged from moderate to very good; median test–retest reliability ranged from moderate to good. Acceptability was demonstrated for data collectors and participants. Mean time to complete the OSST was 7 min.ConclusionsThe OSST is a novel tool that can record a range of clinical oral features including tooth count, denture wear, occluding pairs of teeth and functional dentition, oral cleanliness, gum condition, carious cavitation and oral pain that will be useful within health surveys of people with mild–moderate IDs and similarly neglected populations. The tool demonstrates promising attributes and acceptability. From this study, the OSST appears to be a robust tool that can be incorporated into general data collection for people with mild–moderate IDs and similar populations. A key feature is that it can be administered by well‐trained non‐dentists.