bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of the granite-forming minerals on the surface roughness in the milling processes
Authors: Cserta Eszter , Gyurika István Gábor 
Published: January 2021

AbstractMilling of granite surface is getting increasingly important in the industry. A major problem is that the effect of granite minerals on surface roughness is currently unknown. The research in this article aims to examine these effects. During the experiment, six surfaces with different cutting speeds were examined on the surface of three different granite samples. The color of the various minerals was determined by light microscopy, and a scanning electron microscope (SEM) and X-ray diffractometer (XRD) were used to analyze the composition of the samples, and a confocal microscope was used to measure the surface roughness of each mineral. From the results of the investigations, we deduced different correlations between the minerals forming granite and the surface roughness. Area-based surface roughness was used in this study because it results more accurate data. From the results, we conclude that the roughness of different surface-forming minerals varies greatly. This causes a high average surface roughness value.
Purinergic smooth muscle contractions in the human prostate: estimation of relevance and characterization of different agonists
Authors: Spek Annabel , Li Bingsheng , Rutz Beata , Ciotkowska Anna , Huang Ru , Liu Yuhan , Wang Ruixiao , Strittmatter Frank , Waidelich Raphaela , Stief Christian G. , Hennenberg Martin 
Published: January 2021

AbstractNon-adrenergic prostate smooth muscle contractions may account for the limited effectiveness of α1-adrenoceptor antagonists, which are the first-line option for medical treatment of voiding symptoms suggestive of benign prostatic hyperplasia. In non-human prostates, purinergic agonists induce contractions reaching similar magnitudes as α1-adrenergic contractions. However, evidence for the human prostate is highly limited, and pointed to much weaker purinergic contractions. Here, we examined contractions of different purinergic agonists in human prostate tissues. Tissues were obtained from radical prostatectomy. Contractions were studied in an organ bath, and expression of purinergic receptors was studied by RT-PCR. Electric field stimulation (EFS)–induced contractions amounted to 104% of KCl-induced contractions (95% CI: 84–124%). From all tested agonists, only ATP induced concentration-dependent contractions, reaching an average maximum of 18% (12–24%) of KCl. Maximum tensions following application of other agonists averaged to 7.1% of KCl for α,β-methylene-ATP (1.8–12.4%), 3.9% for β,γ-methylene-ATP (2.0–5.4%), 3.1% for 2-methylthio-ATP (− 0.1–6.3%), and 5.1% for ATPγS (1.0–9.2%). Responses were not affected by the P2X antagonist NF023 or the P2Y antagonist PPADS. mRNA expression of P2X1-4 correlated with expression of a marker for catecholaminergic nerves, although neither ATP, NF023, nor PPADS changed EFS-induced contractions. Correlation between expression of receptors and the smooth muscle marker calponin was not observed. Our findings point to a low relevance of purinergic contractions in the human prostate, compared to other contractile stimuli in the human prostate and compared to purinergic contractions in non-human prostates. Purinergic contractions in the human prostate are not sensitive to NF023 or PPADS.
Does co-presence affect the way we perceive and respond to emotional interactions?
Authors: Bachmann Julia , Zabicki Adam , Gradl Stefan , Kurz Johannes , Munzert Jörn , Troje Nikolaus F. , Krueger Britta 
Published: January 2021

AbstractThis study compared how two virtual display conditions of human body expressions influenced explicit and implicit dimensions of emotion perception and response behavior in women and men. Two avatars displayed emotional interactions (angry, sad, affectionate, happy) in a “pictorial” condition depicting the emotional interactive partners on a screen within a virtual environment and a “visual” condition allowing participants to share space with the avatars, thereby enhancing co-presence and agency. Subsequently to stimulus presentation, explicit valence perception and response tendency (i.e. the explicit tendency to avoid or approach the situation) were assessed on rating scales. Implicit responses, i.e. postural and autonomic responses towards the observed interactions were measured by means of postural displacement and changes in skin conductance. Results showed that self-reported presence differed between pictorial and visual conditions, however, it was not correlated with skin conductance responses. Valence perception was only marginally influenced by the virtual condition and not at all by explicit response behavior. There were gender-mediated effects on postural response tendencies as well as gender differences in explicit response behavior but not in valence perception. Exploratory analyses revealed a link between valence perception and preferred behavioral response in women but not in men. We conclude that the display condition seems to influence automatic motivational tendencies but not higher level cognitive evaluations. Moreover, intragroup differences in explicit and implicit response behavior highlight the importance of individual factors beyond gender.
Short stem total hip arthroplasty with the direct anterior approach demonstrates suboptimal fixation
Authors: Garavaglia Guido , Gonzalez Amanda , Barea Christophe , Peter Robin , Hoffmeyer Pierre , Lübbeke Anne , Hannouche Didier 
Published: January 2021

Abstract
Purpose
Short stems use has increased substantially despite variable results reported in the literature. The purpose of this study was to report the rate of complications using a short stem implanted through the direct anterior approach (DAA), and to evaluate mid-term clinical and radiological results focusing on femoral stem fixation.

Methods
Between April 2009 and November 2014, 698 elective total hip arthroplasties (THAs) were performed using a fully hydroxyapatite-coated short stem (AMIStem-H®). The mean age was 65.7 years (SD 12.6). Patients were invited for clinical and radiological evaluation, and to complete patient-reported outcomes questionnaires at two and five years after surgery. The mean follow-up was 6.2 years (range 2–9.73 years).

Results
During the study period, 59 (8.5%) patients died and 24 (3.4%) were lost to follow-up. There were six (0.9%) dislocations and 12 (1.7%) fractures, seven occurred intra-operatively. Twenty-nine (4.2%) THAs required revision surgery. Eleven THAs were revised for aseptic loosening of the stem at a mean 4.9 years (1.2–7.3 years). Five years after surgery, radiographs of 324 THAs (324/425 eligible = 76.2%) were available. Stem subsidence ≥ 2 mm was present in 42 cases (12.9%), proximal radiolucencies in 101 hips (31.5%), cortical thickening in 52 (16.0%), and a pedestal in 219 (67.6%). An Engh score between − 10 and 0 was associated with lower HHS pain subscore (p = 0.005), a higher risk of stem revision for aseptic loosening (18.8% vs. 2.7%; p = 0.008), and was more frequent in younger patients with ASA score 1.

Conclusion
Patients presenting radiological alterations at five years had an increased risk of revision for aseptic stem loosening and also inferior clinical results. Our study warrants further continued scrutiny of mid- and long-term survivorship of the AMIStem-H®, with radiological results at five years indicating suboptimal fixation of the stem in younger and active patients.
Potential shifts in climate zones under a future global warming scenario using soil moisture classification
Authors: Li Mingxing , Wu Peili , Sexton David M. H. , Ma Zhuguo 
Published: January 2021

AbstractClimate zones fundamentally shape the patterns of the terrestrial environment and human habitation. How global warming alters their current distribution is an important question that has yet to be properly addressed. Using root-layer soil moisture as an indicator, this study investigates potential future changes in climate zones with the perturbed parameter ensemble of climate projections by the HadGEM3-GC3.05 model under the CMIP5 RCP8.5 scenario. The total area of global drylands (including arid, semiarid, and subhumid zones) can potentially expand by 10.5% (ensemble range is 0.6–19.0%) relative to the historical period of 1976–2005 by the end of the 21st century. This global rate of dryland expansion is smaller than the estimate using the ratio between annual precipitation total and potential evapotranspiration (19.2%, with an ensemble range of 6.7–33.1%). However, regional expansion rates over the mid-high latitudes can be much greater using soil moisture than using atmospheric indicators alone. This result is mainly because of frozen soil thawing and accelerated evapotranspiration with Arctic greening and polar warming, which can be detected in soil moisture but not from atmosphere-only indices. The areal expansion consists of 7.7% (–8.3 to 23.6%) semiarid zone growth and 9.5% (3.1–20.0%) subhumid growth at the expense of the 2.3% (–10.4 to 7.4%) and 12.6% (–29.5 to 2.0%) contraction of arid and humid zones. Climate risks appear in the peripheries of subtype zones across drylands. Potential alteration of the traditional humid zone, such as those in the mid-high latitudes and the Amazon region, highlights the accompanying vulnerability for local ecosystems.
The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer’s disease
Authors: Matchett Billie J. , Grinberg Lea T. , Theofilas Panos , Murray Melissa E. 
Published: January 2021

AbstractAlzheimer’s disease (AD) is neuropathologically characterized by the intracellular accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β plaques, which affect certain brain regions in a progressive manner. The locus coeruleus (LC), a small nucleus in the pons of the brainstem, is widely recognized as one of the earliest sites of neurofibrillary tangle formation in AD. Patients with AD exhibit significant neuronal loss in the LC, resulting in a marked reduction of its size and function. The LC, which vastly innervates several regions of the brain, is the primary source of the neurotransmitter norepinephrine (NE) in the central nervous system. Considering that NE is a major modulator of behavior, contributing to neuroprotection and suppression of neuroinflammation, degeneration of the LC in AD and the ultimate dysregulation of the LC–NE system has detrimental effects in the brain. In this review, we detail the neuroanatomy and function of the LC, its essential role in neuroprotection, and how this is dysregulated in AD. We discuss AD-related neuropathologic changes in the LC and mechanisms by which LC neurons are selectively vulnerable to insult. Further, we elucidate the neurotoxic effects of LC de-innervation both locally and at projection sites, and how this augments disease pathology, progression and severity. We summarize how preservation of the LC–NE system could be used in the treatment of AD and other neurodegenerative diseases affected by LC degeneration.
Results after spica cast immobilization following hip reconstruction in 95 cases: is there a need for alternative techniques?
Authors: Pisecky L. , Großbötzl G. , Gahleitner M. , Haas C. , Gotterbarm T. , Klotz M. C. 
Published: January 2021

Abstract
Introduction
Developmental dysplasia of the hip (DDH), neurogenic dysplasia of the hip (NDH), and Perthes disease often require surgical treatment. Spica casting is a common postoperative immobilization.
The purpose of this study was to evaluate the complications related to the immobilization.

Materials and methods
In a retrospective analysis, we included 83 patients (95 hips), who underwent hip reconstructive surgery between 2008 and 2018. We had 43 female and 40 male patients. Age reached from 3 months to 19 years. All patients were treated with a spica cast postoperatively for a 6-week protocol. Complications were analyzed using the full medical documentation and classified according to Clavien–Dindo.

Results
We had complications in 23 patients (27.7%). We counted superficial skin lesions in seven, deep skin lesions in three, spasticity of adductors in three, subluxation in two, infection of the plate in one, fracture of the plate in one, compliance problem in one, dislocations of the cast in two, reluxation in one, delayed bone healing in one and spasticity of knee flexors in one case. According to the classification of Clavien–Dindo, we were able to count ten type I, four type II, nine type III, zero type IV and zero type V adverse events.

Conclusion
The usage of a spica cast after hip reconstructive surgery is still the most popular way of aftertreatment. It has a low complication rate, which may be lowered by well-applied casts and foam padding. Known complications such as spasticity in patients with cerebral palsy, skin lesions, and pressure sores should be observed and avoided. Shorter protocols for immobilization with the usage of foam padding and foam splints lead to less complications.

Clinical relevance
Evidence level level IV, case series
Distinctive pattern of left–right asymmetry of ovarian benign teratomas in Chinese population: a 12-year-long cross-sectional study
Authors: He Xiaoqing , Zhao Xiaoya , Wang Xiaofeng , Liang Guiling , Qi Hang , Zhu Chenfeng , Huang Zhen , Zhang Jian 
Published: January 2021

Abstract
Purpose
Given the lack of research on the left–right asymmetry of ovarian teratoma among Chinese patients, this study aimed to determine the lateral distribution and related clinical characteristics of Chinese ovarian teratoma patients treated at a single center.

Methods
We conducted a cross-sectional study of surgical patients pathologically diagnosed with ovarian teratomas in the gynecology inpatient department of the International Peace Maternity and Child Health Hospital in Shanghai between July 2006 and July 2018.

Results
Of the 4417 patients with ovarian teratoma, 3835 were finally analyzed. There were 2030 (53.24%) cases of right-sided benign ovarian teratoma versus 1783 (46.76%) cases of left-sided benign teratoma (P < 0.001). The recurrence rate of benign ovarian teratoma was 4.2%; recurrence occurred more often on the left side (left vs. right = 55 vs. 45%, P = 0.033). Compared with the right-sided ovarian teratoma patients, left-sided ones had significantly high recurrence risk (OR 1.430; 95% CI 1.03–1.99). The rate of ovarian torsion in patients with ovarian mature cystic teratomas (MCTs) during intrauterine pregnancy was 3.17 versus 1.72% in non-pregnant MCT patients (P = 0.049). For those MCT patients with intrauterine pregnancy, ovarian torsion occurs more often on the right side (left vs. right = 16.67 vs. 83.33%, P = 0.028).

Conclusion
This study confirms a distinctive right-side dominance of benign ovarian teratomas. Compared with the right side, recurrent ovarian teratomas occur more often on the left side, requiring close follow-up. Intrauterine pregnancy may increase the risk of ovarian torsion, particularly on the right side, in MCT patients.
Double reinsertion including Whitnall’s ligament in aponeurotic ptosis surgery
Authors: Pfeiffer Nuria , Pfeiffer Markus , Sainz Alberto Reche , Fernandez Nicolas Toledano 
Published: January 2021

Abstract
Purpose
The results of a technique with a double reinsertion of the aponeurosis to the tarsus and aponeurosis to Whitnall’s ligament (ATW) were compared with a simple reinsertion of the aponeurosis to the tarsus (AT) in acquired aponeurotic palpebral ptosis surgery.

Methods
Analytical, observational, retrospective, cohort study. Seven hundred and twenty-two consecutive cases with acquired aponeurotic palpebral ptosis have been treated surgically between 2000 and 2012 and have been followed up for 5 years. The cases were divided into two cohorts according to the applied surgical technique (AT vs ATW).

Results
The mean postoperative MRD after 1 month in cohort AT was 1 mm lower than in ATW (3 ± 0.9 mm vs 4 ± 1 mm). The mean MRD in the long-term follow-up (5 years) was 1 mm lower in cohort AT than in ATW (2.9 ± 1.5 mm vs 3.9 ± 0.9 mm). The rate of long-term recurrence (5 years) was 15% higher in A-T than in A-T-W (20% vs 5%). 70.5% of the eyes studied intra-surgically presented gaps between the Whitnall ligament and the aponeurosis, an anatomical area that we describe as the upper transition zone (UTZ). In an independent analysis, only those patients with open UTZ were evaluated and it was observed that those operated with A-T-W presented elevations greater than 1 mm compared to those operated with the AT technique (4 ± 0.9 mm A-T-W vs 2.8 ± 1 mm A-T) and a much lower recurrence rate (5.4% A-T vs 38.09% A-T-W).

Conclusions
In our study, the A-T-W technique achieved better results in terms of palpebral elevation and fewer recurrences compared to the A-T technique in all cases studied with aponeurotic ptosis. However, it particularly demonstrates its superiority in patients with large gaps in the UTZ.
Elastic spherical inhomogeneity in an infinite elastic solid: an exact analysis by an engineering treatment of the problem based on the corresponding cavity solution
Authors: Amstutz Hans , Vormwald Michael 
Published: January 2021

AbstractIn the present work, solutions are recapitulated according to the theory of elasticity for the deformations of an adhesive spherical inhomogeneity in an infinite matrix under remote uniform axial and axial-symmetrical radial tension. Stress fields in the inhomogeneity and at the interface in the matrix are provided, too. It is shown that the sphere is deformed to a spheroid under any of the loading cases considered. Due to the axial-symmetric setup of the problem, the deformation is fully described by the two displacement values at line segments on the principal axes of the spheroid. The displacements depend on the applied remote load and on two traction fields at the inhomogeneity-matrix interface. For any combination of inhomogeneity and matrix stiffness, the condition of compatibility of deformations yields a system of two linear equations with the two magnitudes of the tractions as unknowns. Thus, the problem is reduced to a formulation for solving a twofold statically indetermined structure. The system is solved and the exact solution of the general spherical inhomogeneity problem with differing stiffness in terms of Young’s moduli and Poisson’s ratios of inclusion and matrix is presented.
Time-series analysis of heart rate and blood pressure in response to changes in work rate before and after 60 days of 6° head down tilt bed rest
Authors: Koschate Jessica , Thieschäfer L. , Drescher U. , Zieschang T. , Hoffmann U. 
Published: January 2021

Abstract
Purpose
Cardiovascular regulation during exercise, described using time series analysis, is expected to be attenuated after bed rest (BR) and this effect will be dampened by a reactive jumps countermeasure.

Methods
Twenty subjects (29 ± 6 years, 23.6 ± 1.7 kg m−2) were tested on a cycle ergometer 9 days (BDC-9) before the beginning of BR as well as 2 (R + 2) and 13 days (R + 13) after the end of BR, applying moderate pseudo-random binary (PRBS) work rate changes. Heart rate (HR) and mean arterial blood pressure (mBP) were measured beat-to-beat and interpolated to 1 s intervals. HR and mBP were cross-correlated [CCF(HR-mBP)] during the PRBS. Eleven subjects participated in a reactive jump countermeasure (JUMP) during the BR period, the other part of the group served as control group (CTRL).

Results
In the CTRL group, significantly lower CCF(HR-mBP) values during BDC-9 were observed compared to R + 2 during the lags 20–25 s and significantly higher values during the lags − 39 s to − 35 s. In the JUMP group, significantly lower CCFs were only observed at R + 2 compared with BDC-9 during the lags 23 s and 24 s, whereas the CCFs for BDC-9 were significantly higher at several lags compared with R + 13.

Conclusion
Attenuations in the regulation of the cardiovascular system during cycling exercise after BR were found in the CTRL group of the RSL study. Cardiovascular regulation in the JUMP group was improved compared to values before the beginning of BR, suggesting the effectiveness of the reactive jumps countermeasure to mitigate the deleterious effects of prolonged BR.
Salient brain entities labelled in P2rx7-EGFP reporter mouse embryos include the septum, roof plate glial specializations and circumventricular ependymal organs
Authors: Ortega Felipe , Gomez-Villafuertes Rosa , Benito-León María , Martínez de la Torre Margaret , Olivos-Oré Luis A. , Arribas-Blazquez Marina , Gomez-Gaviro María Victoria , Azcorra Arturo , Desco Manuel , Artalejo Antonio R. , Puelles Luis , Miras-Portugal María Teresa 
Published: January 2021

AbstractThe purinergic system is one of the oldest cell-to-cell communication mechanisms and exhibits relevant functions in the regulation of the central nervous system (CNS) development. Amongst the components of the purinergic system, the ionotropic P2X7 receptor (P2X7R) stands out as a potential regulator of brain pathology and physiology. Thus, P2X7R is known to regulate crucial aspects of neuronal cell biology, including axonal elongation, path-finding, synapse formation and neuroprotection. Moreover, P2X7R modulates neuroinflammation and is posed as a therapeutic target in inflammatory, oncogenic and degenerative disorders. However, the lack of reliable technical and pharmacological approaches to detect this receptor represents a major hurdle in its study. Here, we took advantage of theP2rx7-EGFP reporter mouse, which expresses enhanced green fluorescence protein (EGFP) immediately downstream of theP2rx7proximal promoter, to conduct a detailed study of its distribution. We performed a comprehensive analysis of the pattern of P2X7R expression in the brain of E18.5 mouse embryos revealing interesting areas within the CNS. Particularly, strong labelling was found in the septum, as well as along the entire neural roof plate zone of the brain, except chorioidal roof areas, but including specialized circumventricular roof formations, such as the subfornical and subcommissural organs (SFO; SCO). Moreover, our results reveal what seems a novel circumventricular organ, named by us postarcuate organ (PArcO). Furthermore, this study sheds light on the ongoing debate regarding the specific presence of P2X7R in neurons and may be of interest for the elucidation of additional roles of P2X7R in the idiosyncratic histologic development of the CNS and related systemic functions.