bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term results of ulnar and radial reconstruction with interpositional grafting using the deep inferior epigastric artery for chronic hand ischemia
Authors: Ahn Hee Chang , Oh Se Won , Yoon Jung Soo , Park Seong Oh 
Published: November 2021

AbstractChronic hand ischemia causes cold intolerance, intractable pain, and digital ulceration. If ischemic symptoms persist despite pharmacologic treatments, surgical interventions should be considered. This retrospective study evaluated the long-term results after ulnar and radial reconstruction using an interpositional deep inferior epigastric artery (DIEA) graft combined with periarterial sympathectomy. Patients who underwent this surgery from March 2003 to February 2019 were included. To evaluate variables influencing recurrence after the procedure, patients were divided into the recurred and non-recurred groups and their data were compared. Overall, 62 cases involving 47 patients were analyzed (16 and 46 cases in the recurred and non-recurred groups, respectively). The median DIEA graft length was 8.5 cm. The rates of rheumatic disease and female patients were significantly higher in the recurred than in the non-recurred group, without significant between-group differences in postoperative complication rates. In the multivariate analysis, underlying rheumatic disease and graft length had significant effects on recurrence. In Kaplan–Meier analysis, the 5- and 10-year symptom-free rates were 81.3% and 68.0%, respectively, with lower rates for cases with rheumatic disease. Thus, arterial reconstruction using an interpositional DIEA graft provides long-term sustainable vascular supply in patients with chronic hand ischemia, especially in those without rheumatic disease.
First-line osimertinib in elderly patients with epidermal growth factor receptor-mutated advanced non-small cell lung cancer: a retrospective multicenter study (HOT2002)
Authors: Yamamoto Gaku , Asahina Hajime , Honjo Osamu , Sumi Toshiyuki , Nakamura Atsushi , Ito Kenichiro , Kikuchi Hajime , Hommura Fumihiro , Honda Ryoichi , Yokoo Keiki , Fujita Yuka , Oizumi Satoshi , Morita Ryo , Ikezawa Yasuyuki , Tanaka Hisashi , Kimura Nozomu , Sasaki Takaaki , Sukoh Noriaki , Takashina Taichi , Harada Toshiyuki , Dosaka-Akita Hirotoshi , Isobe Hiroshi ,   the Hokkaido Lung Cancer Clinical Study Group Trial, Yamamoto Gaku , Asahina Hajime , Honjo Osamu , Sumi Toshiyuki , Nakamura Atsushi , Ito Kenichiro , Isobe Hiroshi , Kikuchi Hajime , Hommura Fumihiro , Honda Ryoichi , Yokoo Keiki , Fujita Yuka , Oizumi Satoshi , Morita Ryo , Ikezawa Yasuyuki , Tanaka Hisashi , Kimura Nozomu , Sasaki Takaaki , Sukoh Noriaki , Takashina Taichi , Harada Toshiyuki , Akita Hirotoshi 
Published: November 2021

AbstractOsimertinib is a standard of care therapy for previously untreated epidermal growth factor receptor mutation-positive non-small cell lung cancer. However, limited data exist regarding the efficacy and safety of osimertinib as a first-line therapy for elderly patients aged 75 years or older. To assess the potential clinical benefits of osimertinib in this population, this retrospective multi-institutional observational study included 132 patients with non-small cell lung cancer (age ≥ 75 years), who received osimertinib as first-line treatment. The proportion of patients with 1-year progression-free survival was 65.8% (95% confidence interval 57.1–73.5). The median progression-free survival was 19.4 (95% confidence interval 15.9–23.9) months. The median overall survival was not reached (95% confidence interval 24.6–not reached). The frequency of pneumonitis was 17.4%, with a grade 3 or higher rate of 9.1%. More than two-thirds of treatment discontinuations due to pneumonitis occurred within 3 months of starting osimertinib, and the prognosis of patients with pneumonitis was unsatisfactory. Osimertinib is one of the effective first-line therapeutic options for patients aged 75 years or older; however, special caution should be exercised due to the potential development of pneumonitis.
A dye encapsulated zinc-based metal–organic framework as a dual-emission sensor for highly sensitive detection of antibiotics
Authors: Wang Kang , Duan Yuhan , Chen Jiajing , Wang Haiying , Liu Huiyan 
Published: November 2021

Incorporated amide groups enable the tetratopic linker to facilitate diversity nets of lon (1) and nbo (2). Importantly, fluorescent dye DMASM can be encapsulated into 2 as a dual-emitting sensor for highly sensitive detection of antibiotics.
Cryo-EM structures of τ filaments from human brain
Authors: Goedert Michel 
Published: November 2021

Abstract
Electron cryo-microscopy (cryo-EM) has made it possible to determine near-atomic structures of τ filaments from human brain. Previous work had shown that the cores of paired helical and straight filaments of Alzheimer's disease are made of two identical, but differently arranged C-shaped protofilaments. In recent years, cryo-EM has shown that the Alzheimer τ fold is 79 amino acids long. Five of the eight β-strands give rise to two antiparallel β-sheets, with the other three forming a β-helix. High-affinity binding sites of positron emission tomography ligand APN-1607 (PM-PBB3) are in the β-helix region. The Alzheimer fold contrasts with the 94 amino acid-long Pick fold, which is J-shaped and comprises nine β-strands that give rise to four antiparallel β-sheets, in the absence of a β-helix. Chronic traumatic encephalopathy τ fold is similar to the Alzheimer fold, but differs in the β-helix region, which is larger and contains a non-proteinaceous density that is probably hydrophobic. These folds are mostly two-layered. By contrast, the 107 amino acid τ fold of the 4R tauopathy corticobasal degeneration is four-layered and comprises 11 β-strands. It contains an internal, probably hydrophilic, density that is surrounded by τ. The τ folds described here share the presence of microtubule-binding repeats 3 and 4, as well as 10–13 amino acids after repeat 4.
Reliabilität der auditiv-perzeptiven RBH-Beurteilung und Vergleich mit dem akustischen Messmittel der Vospector-Analyse
Authors: Hermle Patricia , Grassinger Robert , Thomas Fabian 
Published: November 2021

ZusamenfassungIm logopädischen Alltag werden regelmäßig Dysphonien beurteilt. Neben der perzeptiven RBH-Skala (Rauigkeit R, Behauchtheit B und die Heiserkeit H) finden wir auch computergestützte, akustische Messmittel, wie die Vospector-Analyse von lingWaves (Irregularität, Rauschen und Gesamtgrad). Zur Untersuchung der Korrelation von Text und Vokal, der Reliabilität der RBH-Skala, der Vospector-Analyse und auch deren Korrelation wurde die Stimmqualität (Text und Vokal) von 6 Fallbeispielen durch 54 Logopäd*innen bewertet. Die Retest-Reliabilität der RBH-Skala, die Korrelation von Text und Vokal sowie von RBH und Vospector wurden ausgewertet. Die Retest-Reliabilität der RBH-Skala war in großen Teilen inkongruent. Die Ergebnisse deuten zudem auf geringe Zusammenhänge der perzeptiven Beurteilung eines Textes und eines Vokals hin. Hierbei wurden bedeutsame Unterschiede zwischen den Fallbeispielen beobachtet, was mitunter in der Diskussion aufgegriffen wird.
ICA-Deutschland e.V.: Stand und Ausblick
Authors: Mündner-Hensen Bärbel 
Published: November 2021

ZusammenfassungDer ICA-Deutschland e.V. wurde 1993 als erste IC-Organisation in Europa gegründet. Seitdem setzt sich der Förderverein auf nationaler und internationaler Ebene für mehr Aufklärung und Information von Ärzten und Öffentlichkeit ein, initiierte zahlreiche Forschungsprojekte und konnte dazu beitragen, dass sich Diagnose und Therapiemöglichkeiten der Interstitiellen Cystitis deutlich verbesserten. Auf der Webseite des ICA finden Betroffene kostenfrei ausführliche Informationen rund um die Interstitielle Cystitis: aktuelle Behandlungsmethoden, Ernährungsratgeber, Patientenberichte, einen Newsletter und mehr.Es existiert eine mangelnde bis keine Bereitschaft der Krankenkassen zur Kostenbeteiligungen oder Kostenerstattungen der Diagnose und Therapiemaßnahmen. Und das obwohl eine wissenschaftlich fundierte Versorgungsstudie vorliegt, eine hochwertige S2K-Leilinie mit Evidenznachweisen vorliegt, die über Diagnostik und Therapie präzise Auskunft gibt, viele erfolgversprechende Medizinprodukte entwickelt wurden, ein von der EMA zugelassenes Arzneimittel existiert.
Interstitielle Zystitis: Interventionelle und operative Therapie – mehr als eine Ultima Ratio
Authors: Bschleipfer Thomas , Kaftan Björn 
Published: November 2021

ZusammenfassungDie interstitielle Zystitis ist eine häufig unterdiagnostizierte, chronisch-rezidivierend bis chronisch-progredient verlaufende Harnblasenerkrankung, deren Pathogenese und Ätiologie noch weitgehend unklar ist. Die Erkrankung selbst ist nicht heilbar, eine Therapie erfolgt symptomatisch. Neben konservativen und medikamentösen Therapieansätzen stehen den Patienten auch eine Vielzahl an interventionell-operativen Verfahren zur Verfügung. Dazu zählen neben intravesikalen Instillationen, transurethralen Verfahren wie Injektionen von Botulinum-Toxin A, Kortikosteroiden und Lokalanästhetika, Hydrodistension und Neuromodulation auch operative Eingriffe wie (Laser-) Fulguration, Resektion und Zystektomie. Obwohl operative Interventionen bei Vorliegen einer interstitiellen Zystitis meist sehr spät in Erwägung gezogen werden (sollen) und prinzipiell als Ultima ratio bezeichnet werden, weisen diese Eingriffe bei guten bis sehr guten Ansprechraten und meist überschaubaren Komplikationen ein günstiges Nutzen-Risikoverhältnis auf. Eine allgemeine Pauschalisierung der Intervention als Ultima ratio sollte daher vermieden werden und ihr Einsatz individuell abgestimmt auf den jeweiligen Patienten erfolgen.
Functional Movement Screen Task Scores and Joint Range-of-motion: A
Construct Validity Study
Authors: Hincapié Cesar A. , Tomlinson George A. , Hapuarachchi Malinda , Stankovic Tatjana , Hirsch Steven , Carnegie Danielle , Richards Doug , Frost David , Beach Tyson A.C. 
Published: November 2021

AbstractLittle is known about the construct validity of the Functional Movement Screen
(FMS). We aimed to assess associations between FMS task scores and measures of
maximum joint range-of-motion (ROM) among university varsity student-athletes
from 4 sports (volleyball, basketball, ice hockey, and soccer). Athletes
performed FMS tasks and had their maximum ankle, hip and shoulder ROM measured.
Multivariable linear regression was used to estimate associations between FMS
task scores and ROM measurements. 101 university student-athletes were recruited
(52 W/49 M; mean age 20.4±1.9 years). In
general, athletes with higher FMS task scores had greater ROM compared to those
with lower task scores. For example, athletes who scored 2 on the FMS squat task
had 4° (95% CI, 1° to 7°) more uni-articular
ankle dorsiflexion ROM compared with those who scored 1, while those who scored
3 on the FMS squat task had 10° (4° to 17°) more
uni-articular ankle dorsiflexion ROM compared with those who scored 1. Large
variation in ROM measurements was observed. In sum, substantial overlap in joint
ROM between groups of athletes with different FMS task scores weakens the
construct validity of the FMS as an indicator of specific joint ROM.
Hirao Cross-Coupling Reaction as an Efficient Tool to Build Non-natural C2-Phosphonylated Sugars
Authors: Monasson Olivier , Malinowski Maciej , Ferry Angélique , Lubin-Germain Nadège 
Published: November 2021

AbstractA range of C2-phosphonylated sugars have been accessed through a palladium-catalyzed Hirao cross-coupling on 2-iodoglycals using trialkylphosphites as phosphorylating reagents. The developed conditions led to the creation of an unnatural C–P bond on sugars and proved to be compatible with diversely protected glycals (acetyl-, benzyl-, PMB-protected) as well as with unprotected substrates. Several monosaccharides and one disaccharide have been synthesized by applying this methodology. Deprotection conditions are also described.
Computed Tomographic Evaluation of the Accuracy of Minimally Invasive Sacroiliac Screw Fixation in Cats
Authors: Wills Daniel J. , Neville-Towle Jack , Podadera Juan , Johnson Kenneth A. 
Published: November 2021

AbstractObjectives The aim of this study was to report the use of computed tomography (CT) for postoperative evaluation of the accuracy of sacroiliac reduction and minimally invasive screw fixation in a series of five cats.Methods Medical records between January 2016 and March 2017 of cats presenting to the author's institution were reviewed. Included were cats that had undergone minimally invasive sacroiliac screw fixation with a complete medical record and pre- and postoperative radiographs. Screw size was obtained from the medical records. CT images were acquired prospectively and evaluated to assess joint reduction, relative screw size and screw positioning.Results Six sacroiliac luxations and 6 screws were available. Fixation was achieved with either a 2.4 (n = 1) or 2.7 mm (n = 5), 316L stainless steel, cortical bone screw. Mean screw size as a proportion of sacral diameter was 47.7%. Sacroiliac reduction >90% in the craniocaudal plane and sacral screw purchase >60% of the sacral width were achieved in 3/5 cases. Mean dorsoventral screw angulation was 1.6 degrees (range: −9.7 to 11.7 degrees) and craniocaudal angulation was −4.5 degrees (range: −16.6 to 6.6 degrees). Complications included screw loosening in the one case of bilateral repair and penetration of the neural canal in one case which was not detected with postoperative radiographic evaluation.Clinical Significance CT evaluation provides a useful method for the assessment of sacroiliac reduction and the accuracy of screw placement.
Perception, Knowledge, and Professional Behavior of Dentists about Silver Diamine Flouride: A Nationwide Survey
Authors: Abbas Beenish , Aamer Sidra , Anwar Fizza Sahar , Farhan Farah , Wajahat Mehreen , Khurshid Zohaib 
Published: November 2021

Abstract
Objectives The aim of this study was to survey the educational experiences, knowledge, and attitude of dentists in Pakistan about the professional use of silver diamine fluoride (SDF). This study also aimed to determine if SDF educational experience at the undergraduate level can result in a more positive attitude and increased clinical usage of SDF.
Materials and Methods This was a cross-sectional survey, conducted at multiple dental institutes across Pakistan using a pre-validated questionnaire to assess the knowledge, experience, and professional expertise of dentists regarding the use of SDF. The data were entered and analyzed using the SPSS (version 23.0) data management software by IBM.
Results The results of this study were deemed significant in terms of achievement of the study aims. The majority of the responders, 178 (79.8%), reported online resources to be the main source of information about SDF treatment, whereas 103 (46.1%) responders gained information from a dental journal. A higher number of consultants were reported to be well educated regarding SDF treatment during their residency training as compared with demonstrators, house officers, and postgraduate trainees (p < 0.001). About 64 (28.7%) responders agreed that SDF is a better alternative treatment for children with behavioral issues, 74 (33.2%) agreed that it is a better treatment option for medically fragile patients, and 79 (35.4%) agreed that it can be used as an alternative for patients with dental anxiety. It was agreed by 82 (36.8%) responders that SDF is a good treatment option for patients who recently have received chemotherapy radiation therapy.
Conclusion It is the need of time to put all educational efforts together to enhance knowledge regarding the use, advantages, and potential problems of SDF.
O2 solvation cavity in voids of ionic liquids studied by the solvatochromic red shift of O2(1Δg) phosphorescence
Authors: Yoshida Tsuyoshi , Okoshi Masayuki , Kawai Akio 
Published: November 2021

Phosphorescence spectroscopy of singlet oxygen [=O2(1Δg)] was applied to study the solvation properties of small solute molecule, O2, in ionic liquids. Unlike conventional molecular solvents, the spectral red shift of the O2(1Δg) phosphorescence in ionic liquids from the gas phase was found to depend not only on the refractive index of solvents but also on the vdW volume of anions. This unusual spectral shift of the O2(1Δg) luminescence is interpreted by considering the size of solvation cavities in voids, which is estimated by analyzing the free volume in ionic liquids. These results suggest the potential of the O2(1Δg) phosphorescence spectral shift measurement in the study of molecular-scale voids in ionic liquids.
Optimisation of the efficiency of tapered erbium-doped optical fibre
Authors: Khudyakov M.M. , Levchenko A.E. , Vel’miskin V.V. , Bobkov K.K. , Aleshkina S.S. , Bubnov M.M. , Yashkov M.V. , Guryanov A.N. , Kotov L.V. , Likhachev M.E. 
Published: November 2021

Abstract
We have developed a cladding pumped tapered erbium-doped fibre with a record-high core diameter for erbium-doped fibres (100 mm) and a near diffraction-limited beam quality (μ
2 ∼ 1.3). Optimisation of the tapered fibre parameters provided a high (18 %) efficiency of pump radiation conversion at a wavelength of 976 nm into signal radiation at a wavelength of 1560 nm.
Measurement of the longitudinal relaxation time for the nitrogen nuclear spin in a nitrogen-vacancy colour centre of diamond
Authors: Soshenko V.V. , Cojocaru I.S. , Bolshedvorskii S.V. , Rubinas O.R. , Smolyaninov A.N. , Vorobyov V.V. , Sorokin V.N. , Akimov A.V. 
Published: November 2021

Abstract
A longitudinal relaxation time of a nitrogen-14 atom nuclear spin for a nitrogen-vacancy (NV) colour centre in diamond is measured by the modified double optical resonance method. The diamond sample was grown by the method of high temperature and pressure and comprised 1 ppm of NVcentres. The longitudinal relaxation time was 43(6) s, which was compared to the time calculated in the model of relaxation due to the electron spin of colour centre interaction with phonons and spin reservoir. The time measured well agrees with predictions of the model.
Neural network for calculating direct and inverse nonlinear Fourier transform
Authors: Sedov E.V. , Chekhovskoy I.S. , Prilepsky J.E. 
Published: November 2021

Abstract
A neural network architecture is proposed that allows a continuous nonlinear spectrum of optical signals to be predicted and an inverse nonlinear Fourier transform (NFT) to be performed for signal modulation. The average value of the relative error in predicting the continuous spectrum by the neural network when calculating the direct NFT is found to be 2.68 × 10−3, and the average value of the relative error in predicting the signal for the inverse NFT is 1.62 × 10−4.
Multicore optical fibre embedded Fabry–Perot sensing element of a bend sensor
Authors: Egorova O.N. , Zhuravlev S.G. , Pustovoy V.I. , Semjonov S.L. 
Published: November 2021

Abstract
We propose a new type of a sensing element of a sensor for measuring the bending direction and magnitude, based on fibre Fabry–Perot interferometers embedded in the cores of multicore optical fibre. The measured sensitivity to the bend radius is 81 pm/m−1. It is found that this sensitivity can be increased by varying the diameters of the optical fibres forming the sensing element.
Correlation between optical fibre diameter and characteristics of tilted fibre Bragg grating-assisted sensors
Authors: Tomyshev K.A. , Dolzhenko E.I. , Butov O.V. 
Published: November 2021

AbstractWe report the results of a study on the influence of the fibre cladding diameter on the accuracy and resolution of tilted fibre Bragg grating-assisted refractometers. Tilted fibre Bragg gratings are an essential element used to develop high-precision fibre sensors for environmental monitoring. Comparative research was performed using one of comprehensive processing algorithms employing spectral envelope analysis. It was shown that the sensor accuracy decreases with decreasign fibre cladding diameter. At the same time, an increase in the diameter deteriorates the spectral pattern contrast, thus impeding the development of high-efficiency sensor elements.
Factors associated with transactional sex among a cohort of gay, bisexual, and other men who have sex with men in Vancouver, Canada
Authors: Armstrong Heather L. , Sang Jordan M. , Skala Ales , Wang Lu , Zhu Julia , Lachowsky Nathan J. , Card Kiffer G. , Benoit Cecilia , Olarewaju Gbolahan , Hogg Robert S. , Moore David M. , Roth Eric A. 
Published: November 2021

Background Gay, bisexual, and other men who have sex with men (GBM) who engage in transactional sex (sex in exchange for drugs, money, or goods) experience increased risk of sexually transmitted infections (STI), including HIV. This study explored additional psychosocial and health-related factors associated with transactional sex among GBM. Methods Respondent-driven sampling was used to recruit GBM in Vancouver, Canada, from 2012 to 2015, with follow up every 6 months until July 2019. We examined factors associated with transactional sex using multivariable three-level mixed-effects modelling. Results Among 698 GBM, 22.1% reported ever receiving drugs, money, or goods for sex. Transactional sex was more likely to be reported by GBM who were younger (<30 years) and who had lower incomes, less education, and insecure housing. GBM reporting transactional sex were more likely to report substance use (i.e. crystal methamphetamine, poppers, GHB, and non-steroid injection drugs) and higher risk sexual behaviours (i.e. more sex partners, sex party attendance, and condomless anal sex with serodifferent or unknown HIV status partners); however, they were no more likely to be living with HIV or to report a recent bacterial STI diagnosis. GBM who reported higher loneliness, anxiety, and cognitive escape were also more likely to report transactional sex. Conclusions More than one-fifth of GBM in Vancouver reported transactional sex and those who did were more likely to also experience psychosocial stressors, increased substance use, and higher risk sexual behaviours. Programs which consider the interconnections of personal, social, and structural challenges faced by GBM engaging in transactional sex are necessary to support improved mental, physical, and sexual health for these men.
A Kalirin missense mutation enhances dendritic RhoA signaling and leads to regression of cortical dendritic arbors across development
Authors: Grubisha Melanie J. , Sun Tao , Eisenman Leanna , Erickson Susan L. , Chou Shinnyi , Helmer Cassandra D. , Trudgen Melody T. , Ding Ying , Homanics Gregg E. , Penzes Peter , Wills Zachary P. , Sweet Robert A. 
Published: November 2021

Significance
Dendrites are long branching processes on neurons that contain small processes called spines that are the site of connections with other neurons, establishing cortical circuitry. Dendrites have long been considered stable structures, with rapid growth prior to adolescence followed by maintenance of size into adulthood. However, schizophrenia is characterized by accelerated reductions of cortical gray matter volume and onset of clinical symptoms during adolescence, with reductions in dendritic length present when examined after death. We show that dendrites retain the capacity for regression and that a mild genetic vulnerability in a regression pathway leads to onset of structural impairments in previously formed dendrites across adolescence. This suggests that targeting specific regression pathways could potentially lead to new therapeutics for schizophrenia.