bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk on Dental Porphyromonas with Esophageal Cancer: A Guangdong Elderly Cohort Study
Authors: Huang Yuzhang , Ma Liyu , Yan Jinyun , Li Zijun , Feng Benson Ting , Li Ting , Wang Ninie Yan , Zhang Guoxi , Lin Sen , Pan Zhongying 
Published: June 2021

Abstract
Objective: To investigate the relationship between Dental Porphyromonas Concentration and Esophageal Cancer in Guangdong, China. Methods: A total of 2031 research objects were included from 2016 and follow-up for 6 years, greater than 65 years old, all are from outpatient department with esophageal foreign body sense. Data are retrospectively analyzing in year 2021. There were 43 cases found to developed esophageal cancer, 7 of them are from exposure group, (high dental porphyromonas group) and 36 from control. Two groups of individuals were retrieved from the Guangdong Provincial Hospital database between year 2016 June to 2021 June. Age, gender, race and region are strictly matched. Both of case and the controls are processing through: a. Specimen collection, b. DNA extraction, c. High-throughput sequencing (screening stage), d. Quantitative determination of target bacteria in the samples of the experimental group by Q-PCR, e. Statistical analysis of experimental data. Two sample t-test are using to detect whether have difference on concentration of Dental Porphyromonas between cases and control group. SAS 15 windows version is used as analytic tools. Results: We found that the odds on having Esophageal Cancer from high dental porphyromonas group is 1.23 times greater than controls (OR=1.23). Also, mean of concentration on Dental Porphyromonas in Esophageal Cancer Group (Cases) are statistically higher than Healthy controls, with a mean of 0.0157 in cases versus 0.0025 in controls, which is 6.54 times higher in Esophageal Group, compare with control group, with P<0.001. Where Hot Tea Drinking Habit are found associated with Esophageal Cancer, with the Odds Ratio (OR) on 1.30, as well as current smoking on an 1.13 odds ratio. Conclusion: The cohort study had found some significant associations on high Dental Porphyromonas with Esophageal Cancer Patient, where this association still lacks of proof to be a determinate causal relationship. Further greater populational longitudinal studies are need to carry out to find out more causal association, as well as finding out Dental Porphyromonas relevant Social Determinant on Esophageal Cancer.
Co-creation of an Acceptable Indigenous Food Diet for Children Under Five in Early Childhood Development Centres
Authors: Nepfumbada Gundo , Dzunamarira Tafadzwa , Mashamba-Thompson Tivani Phosa 
Published: June 2021

Abstract
Background: The use of indigenous food (IF) such as green leafy vegetables and fruits in rural communities has been the main source of food despite being replaced by food high in sugar and fats. Early Childhood Development (ECD) centres are uniquely positioned for positive influence to healthy eating of children. The aim of this study was for ECD stakeholders to co-create an IF diet for children under five in ECD centres.Method: A sequential explanatory mixed method design was employed. We conducted focus group discussion with stakeholders employing the community-based participatory research (CBPR) approach and the nominal group technique ranking method to co-create to an acceptable indigenous food diet for children. Data was analyzed using both qualitative and quantitative methods. A thematic approach to qualitative data analysis with a coding framework guided by Consolidated Framework for Implementation Research (intervention characteristics, inner setting, outer setting, characteristics of individuals involved in implementation and the implementation process) was employed to analyse focus group discussion data. Statistical analysis was employed to analyze quantitative data collected through surveys.Results: Study participants included ECD stakeholders (ECD managers, social workers and dieticians) aged 34-52. Participants identified Ditokomane, Oranges, Mabele soft porridge, Dithotse and Dinawa as components of an IF that are suitable and acceptable for children under five years in ECD centres. Conclusion: ECD stakeholders co-created an IF diet to be implemented in ECD centres for children under five. Stakeholders are of the view that IF diet will have more health benefits on children than the current menu that is being used.
Network Pharmacology Analysis of the Effects of Achyranthis Bidentatae
Radix Plus Semen Vaccariae on Migraine-induced Erectile Dysfunction
Authors: Wang Bin , Li Haisong , Wang Jisheng , Feng Junlong , Deng Sheng , Bao Binghao , Meng Fanchao , Dai Hengheng , Xu Hongsheng , Wang Shizhen 
Published: June 2021

Background and aim:
Achyranthis Bidentatae Radix plus Semen Vaccariae are
traditional Chinese medicines, which have been widely applied in the treatment of migraine and
Erectile Dysfunction (ED) for many years. This study verified the effect of Achyranthis Bidentatae
Radix plus Semen Vaccariae in improving migraine-induced ED and explored its potential
mechanism.

Methods:
Key targets and signaling pathways of Achyranthis Bidentatae Radix plus Semen
Vaccariae in migraine-induced erectile dysfunction treatment were predicted by network
pharmacology. A rat model of migraine was established by nitroglycerin injection. Apomorphine
was injected into rats to screen the migraine-induced erectile dysfunction model, Achyranthis
Bidentatae Radix-Semen Vaccariae granule suspension administered, and erectile function
evaluated. Hematoxylin and eosin staining was used to compare the histological structure of the
penile tissue, while RT-qPCR and Western blotting were used to determine mRNA and protein
levels, respectively.

Results:
Screening allowed us to identify common targets for migraine and ED; the signaling
pathway exhibiting the greatest change was the Myosin light chain kinase- Calcium (MLCK-CaM)
signal pathway. From Western blotting and RT-qPCR, we found that the levels of MLCK mRNA
and protein in rats from Group B rats were significantly higher (P <0.05) than those in Groups A
and C. Furthermore, the mRNA and protein levels of CaM were significantly higher in Group B (P
<0.05) than in Groups A and C.

Conclusion:
Data indicate that the regulatory effects of Achyranthis Bidentatae Radix plus Semen
Vaccariae on migraine-induced ED in a rat model are mediated by the MLCK-CaM signaling pathway.
The Application of Peptides in Glioma: A Novel Tool for Therapy
Authors: Li Li , Chen Jianhong , Ming Yue , Li Bin , Fu Ruoqiu , Duan Dongyu , Li Ziwei , Ni Rui , Wang Xianfeng , Zhou Yueling , Zhang Lin 
Published: June 2021

Background:Glioma is the most aggressive and lethal tumor of the central nervous system. Due to the cellular heterogeneity, the invasiveness, and blood-brain barrier (BBB), current therapeutic approaches, such as chemotherapy and radiotherapy, are poorly to obtain great anti-tumor efficacy. However, peptides, a novel type of therapeutic agent, displayed excellent ability in the tumor, which becomes a new molecule for glioma treatment.Method:We review the current knowledge on peptides for the treatment of glioma through a PubMed-based literature search.Results:In the treatment of glioma, peptides can be used as (i) decoration on the surface of the delivery system, facilitating the distribution and accumulation of the anti-tumor drug in target site;(ii) anti-tumor active molecules, inhibiting the growth of glioma and reducing solid tumor volume; (iii) immune-stimulating factor, and it activating immune cells in the tumor microenvironment or recruiting immune cells to the tumor for breaking out the immunosuppression by glioma cells.Conclusion:The application of peptides has revolutionized the treatment of glioma, which based on targeting, penetrating, anti-tumor activities and immunostimulatory. Moreover, better outcomes have been discovered in combining different kinds of peptides rather than a single one. Until now, more and more preclinical studies have been developed with multifarious peptides, which shows promising results in vitro or vivo with the model of glioma.
Synthesis and Evaluation of Chiral Rhodanine Derivatives Bearing
Quinoxalinyl Imidazole Moiety as ALK5 Inhibitors
Authors: Zheng Chang Ji , Jin Cheng Hua , Zhao Li-Min , Guo Fang Yan , Wang Hui Min , Dou Tong , Da Qi Jun , Xu Wen Bo , Piao Lianxun , Jin Xuejun , Chen Fen-Er , Piao Hu-Ri 
Published: June 2021

Background:
TGF-β signaling pathway inhibition is considered an effective way to prevent
the development of several diseases. In the design and synthesis of TGF-β inhibitors, a rhodanine
compound containing a quinoxalinyl imidazole moiety was found to have strong antimicrobial
activity.

Objective:
The purpose of this work was to investigate the antimicrobial activity of other chiral rhodanine
TGF-β inhibitors synthesized.

Methods:
Two series of 3-substituted-5-(5-(6-methylpyridin-2-yl)-4-(quinoxalinyl-6-yl)- 1Himidazol-
2-yl)methylene)-2-thioxothiazolin-4-ones (12a-h and 13a-e) were synthesized and evaluated
for their ALK5 inhibitory and antimicrobial activity. The structures were confirmed by their 1H
NMR, 13C NMR and HRMS spectra. All the synthesized compounds were screened against Grampositive
strains, Gram-negative strains, and fungi.

Results:
Among the synthesized compounds, compound 12h showed the highest activity (IC50 =
0.416 μM) against ALK5 kinase. Compound 12h exhibited a good selectivity index of >24 against
p38α MAP kinase and was 6.0-fold more selective than the clinical candidate, compound 2 (LY-
2157299). Nearly all the compounds displayed high selectivity toward both Gram-positive and
Gram-negative bacteria. They also showed similar or 2.0-fold greater antifungal activity (minimum
inhibitory concentration [MIC] = 0.5 μg/mL) compared with the positive control compounds Gatifloxacin
(MIC = 0.5 μg/mL) and fluconazole (MIC = 1 μg/mL).

Conclusion:
The findings suggest that the synthesized rhodanine compounds have good ALK5 inhibitory
activity, and merit further research and development as potential antifungal drugs.
Comparative Occurrence of TLR3 and TLR7 Polymorphisms Among Healthy Individual of Various Population
Authors: Singh HariOm , Chauware Vijay , Jakhar Kamini 
Published: June 2021

Background:
Toll-like receptors (TLRs) act as mediators of an innate immune response to
infectious agents. The risk for chronic infection and the development of cancer can be potentially influenced
by the genetic variations in the TLR genes. TLR3 and TLR7 genes have been associated with
susceptibility to several infections and immune diseases. Human populations are very diverse. There
are significant variations in the TLR3 and TLR7 polymorphisms among ethnic groups. Variations within
the population are associated with the disease outcome. Hence, we aimed to compare the occurrence
of TLR3 (rs5743312 C/T, rs3775296 C/A, and rs3775291 C/T) and TLR7 (rs179009 and
rs179008) polymorphisms among healthy individuals of various populations.

Methods:
Genotyping of TLR3 (rs5743312 C/T, rs3775296 C/A, and rs3775291 C/T) and TLR7
(rs179009 and rs179008) polymorphisms were done in 158 healthy controls from the Western India by
utilization of PCR-RFLP.

Result:
In our study population, the prevalence of TLR3 rs5743312 CC, CT, and TT genotypes were
found to be 67.1%, 31.0%, and 1.9%, respectively, whereas genotype distribution of rs3775296 C/A
polymorphism was 65.2%, 31.6%, and 3.2%, respectively and rs3775291C/T was 59.5%, 32.3% and
8.2%, respectively. The occurrence of TLR7 rs179008AA, rs179008AT, rs179008TT genotypes and
rs179008A, rs179008T alleles in the healthy individuals was found to be 81.0%, 16.5%, 2.5% and
89.24%, 10.75%, respectively. The prevalence of TLR7 rs179009AA, rs179009AG, rs179009GG genotypes
and rs179009A, rs179009G alleles in healthy individuals was 63.3%, 29.1%, 7.6% and 63.3%,
36.7%, respectively. The frequency of TLR7 polymorphism was compared with Italian, Asian, European,
African, German and France populations. The frequency of TLR3 polymorphism was compared
with Asians, Caucasians, Taiwanese, Caucasians and Saudi Arabians, Poland, Taiwanese, Italy, Taiwan,
Estonia, Asia and Caucasus. The inter-population differences were observed in the distribution of
TLR3 and TLR7 polymorphisms.

Conclusion:
The prevalence of TLR3 and TLR7 polymorphisms suggested that genotype-phenotype studies
should be conducted among populations to address the innate immune responses against pathogens.
Twitter Users’ Views on Mental Health Crisis Resolution Team Care Compared With Stakeholder Interviews and Focus Groups: Qualitative Analysis
Authors: Chilman Natasha , Morant Nicola , Lloyd-Evans Brynmor , Wackett Jane , Johnson Sonia 
Published: June 2021

Background
Analyzing Twitter posts enables rapid access to how issues and experiences are socially shared and constructed among communities of health service users and providers, in ways that traditional qualitative methods may not.

Objective
To enrich the understanding of mental health crisis care in the United Kingdom, this study explores views on crisis resolution teams (CRTs) expressed on Twitter. We aim to identify the similarities and differences among views expressed on Twitter compared with interviews and focus groups.

Methods
We used Twitter’s advanced search function to retrieve public tweets on CRTs. A thematic analysis was conducted on 500 randomly selected tweets. The principles of refutational synthesis were applied to compare themes with those identified in a multicenter qualitative interview study.

Results
The most popular hashtag identified was #CrisisTeamFail, where posts were principally related to poor quality of care and access, particularly for people given a personality disorder diagnosis. Posts about CRTs giving unhelpful self-management advice were common, as were tweets about resource strains on mental health services. This was not identified in the research interviews. Although each source yielded unique themes, there were some overlaps with themes identified via interviews and focus groups, including the importance of rapid access to care. Views expressed on Twitter were generally more critical than those obtained via face-to-face methods.

Conclusions
Traditional qualitative studies may underrepresent the views of more critical stakeholders by collecting data from participants accessed via mental health services. Research on social media content can complement traditional or face-to-face methods and ensure that a broad spectrum of viewpoints can inform service development and policy.
The Influence of COVID-19 Vaccination on Daily Cases, Hospitalization, and Death Rate in Tennessee, United States: Case Study
Authors: Roghani Ali 
Published: June 2021

Background
The COVID-19 outbreak highlights our vulnerability to novel infections, and vaccination remains a foreseeable method to return to normal life. However, infrastructure is inadequate for the immediate vaccination of the whole population. Therefore, policies have adopted a strategy to vaccinate older adults and vulnerable populations while delaying vaccination for others.

Objective
This study aimed to understand how age-specific vaccination strategies reduce daily cases, hospitalizations, and death rates using official statistics for Tennessee, United States.

Methods
This study used publicly available data on COVID-19, including vaccination rates, positive cases, hospitalizations, and deaths from the Tennessee Department of Health. Data from the first date of vaccination (December 17, 2020) to March 3, 2021, were retrieved. The rates were adjusted by 2019 data from the US Census Bureau, and age groups were stratified into 10-year intervals starting with 21 years of age.

Results
The findings showed that vaccination strategy can reduce the numbers of patients with COVID-19 in all age groups, with lower hospitalization and death rates in older populations. Older adults had a 95% lower death rate from December to March; no change in the death rate of other age groups was observed. The hospitalization rate was reduced by 80% for people aged ≥80 years, while people who were 50 to 70 years old had nearly the same hospitalization rate as prior to vaccination.

Conclusions
This research indicates that targeting older age groups for vaccination is the optimal way to avoid higher transmissions and reduce hospitalization and death rates.
The Oriental Tiny Frog of the Genus <i>Microhyla</i> Tschudi, 1839 (Amphibia: Anura: Microhylidae) Revealed across Geographical Barriers of the Wallace Line
Authors: Eprilurahman Rury , Atmaja Vestidhia Yunisya , Munir Misbahul , Hamidy Amir , Arisuryanti Tuty , Ubaidillah Rosichon 
Published: June 2021

The frog genus Microhyla was considered as the South, East, and Southeast Asian frog species. Microhyla orientalis was described in 2013, distributed in Java and Bali, Indonesia. Thenceforth, it was known as the easternmost distribution of this genus within the oriental region, but recently this species was recorded from the Timor Island and Sulawesi on the Wallace regions. We applied molecular analysis to evaluate the taxonomic status and the origin of the Wallacean population. Phylogenetic analysis using the partial 16S mitochondrial gene demonstrated that the Java, Timor and Sulawesi populations were not significantly different from the Bali population. This Wallacean population of M. orientalis was originated from Java and possibly it is accidentally distributed by humans through the expansion of agricultural activity.
COMPARATIVE STUDY OF FOOD VOCABULARY (DAIRY) IN TURKIC LANGUAGES OF SIBERIA
Authors: Дьячковский Федор Николаевич , Попова Наталья Иннокентьевна , Тазранова Алена Робертовна , Трофимова Светлана Менкеновна , Широбокова Наталья Николаевна 
Published: June 2021

Общеизвестно, что среди специальных лексических номинаций ведущее место принадлежит так называемым народным терминам, которые рассматриваются как слова или словосочетания, служащие средством номинации понятий той или иной сферы профессиональной деятельности.
В статье на основе традиционной системы питания тюркских народов Сибири проводится сравнительно-исторический, этимологический, сопоставительный анализ наименований молочных продуктов питания, являющихся неизменным и важным элементом материальной культуры народов, издавна населяющих обширные пространства Сибири.
Выявлено, что диалектная лексика все ещё оказывает заметное влияние на литературные языки алтайцев, тувинцев, хакасов, якутов, о чём свидетельствует пополнение их лексики народными терминами традиционной материальной культуры из различных источников, особенно из текстов фольклорных, эпических произведений, изданных местными носителями говоров тюркских языков Сибири.
Названия молочных продуктов в тюркских языках Сибири не едины по своему происхождению. В них, наряду с тюркскими корнями, наличествует значительное количество монгольских, тунгусо-маньчжурских элементов. В названиях молочной пищи наблюдается лексика, возникшая в результате формирования и развития диалектов. Данная группа слов в рассматриваемых языках отражает их исторические контакты как с родственными, так и неродственными народами.
It is well known that among special lexical nominations dominate so called folk terms referred to as words or word combinations instrumental for nominating ideas of a certain professional field.
Based on the traditional diet of Turkic peoples of Siberia, we conduct a comparative-historical, etymological, contrastive analysis of dairy names which are a crucial element of the material culture of peoples inhabiting vast taiga areas of Siberia and Russian Far East.
It has been found that dialect vocabulary still has a notable impact on literary languages of the Altai, the Tuva, the Khakass, and the Yakut as evidenced by the fact that folk terms of traditional material culture enter their vocabulary, especially those from folklore, epic texts published by speakers of local dialects of Siberian languages.
Diary names are not uniform in terms of their origin. They show a significant number of Mongolic, Tungusic, and Chinese elements along with Turkic roots. Dairy names include vocabulary resulting from formation and development of dialects. The given group of words in Turkic languages of Siberia reflects historical contacts with both related and non-related peoples.
The Concept and Application of ICT on SMEs performance in Nigeria: Limitation and Challenges
Authors: Teniola Onileowo Temitope , Ireti Fasiku Ayodeji 
Published: June 2021

Small and Medium Enterprises (SMEs) play a vital role in growing and building developing nations' national economy. This study investigates a deep understanding of the influence of Information Communication Technology (ICT) on SMEs' performance in Nigeria. The study found out that most SME owners engage in local business practices in nature of the operation, and marketing strategies are limited within the country. Hence, this is a growing concern, the need to broaden the field of doing business through global integration with ICT aid, which would improve the country's economic growth at large. Based on the literature reviewed, this research work helps to identify the underlying causes, limited ICT readiness, its effectiveness and the need for ICT implementation into business processes, and the knowledge of its potential benefit. Therefore, this paper examines the role of ICT in small businesses' performance; this is estimated to enhance firm productivity and increase profitability, improving overall SMEs’ performance. The study recommends that provision be made for more ICT training facilities, and SMEs need to embrace information and communication technology in terms of resources, networks, and consumer skills. Entrepreneurs are to be enlightened and educated on how ICT can be used to boost operating efficiency. The government should create an enabling environment by offering ICT infrastructure that will promote its growth and implementation in SMEs. This study's data relied on secondary data and current research on SMEs worldwide, focusing on Nigeria.
Keywords: Small and Medium Enterprises, Information Communication Technology, Limitation, Challenges
Film Review as an Approach in Teaching and Learning Fundamental of Islam
Authors: Muhammud Farah Safura 
Published: June 2021

21st century learning requires lecturers to change from traditional learning to student-focused learning as well as applying critical learning and critical thinking skills. The film approach has been used in the subject Fundamental of Islam (CTU101) which is a compulsory subject for year 1 students of UiTM. This study is to identify the effectiveness of the film approach and the ability of students to integrate understanding related to Fundamental of Islam in film contents. The problem statement states two issues; firstly, learning challenges during the COVID-19 pandemic period and secondly learning challenges for Islamic Studies subjects. This study has selected five films that are included in the CTU101 syllabus, namely, My Name Is Khan, 2012, Laskar Pelangi, Jilbab Traveler, and Joker. This research used quantitative data to hundred CTU101 students and analysed using SPSS 20.0 software. This research has shown all positive reactions and happiness from students. Learning through films, well guided from a lecturer will then be a good approach for Islamic Studies subjects. The findings of the study show that students feel fun and easy to apply the fundamentals of Islam in daily life. Hence, watching movies while studying can alleviate some of the stress in the pandemic season that demands learning online.
Keywords: Film Review, Islamic Study, Fundamentals of Islam, CTU101