bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electroactive nanoparticles loaded Silk protein/Chitosan macromolecular injectable hydrogel to improve therapeutic efficacy of mesenchymal stem cells in functional recovery after ischemic myocardial infarction
Authors: Wu Zheng , Cheng Shujuan , Wang Shaoping , Li Wenzheng , Liu Jinghua 
Published: April 2021

Abstract
Background
Currently, cardiac regeneration by stem cell-based tissue engineering is considered an important strategy for overcoming myocardial infarction. Therefore, this study is designed to explore the potential for differentiation of gold nanoparticles loaded injectable Silk protein/Chitosan hydrogel along with mesenchymal stem cells towards a cardiomyogenic phenotype.
Methods
The incorporated gold nanoparticles into chitosan-silk fibroin hydrogel (Au@Ch-SF) was validated by various analysis including FT-IR, NMR, XRD and SEM analysis. The major properties of Au@Ch-SF hydrogel such as weight loss, mechanical test and drug releasing activities also investigated. Further, the mesenchymal stem cells (MS) were encapsulated into hydrogel by incubating the MS cells with 100 µg/mL of Au@Ch-SF hydrogel in a humidified incubator at 37°C for 3 days in the presence of 5% CO2. In vitro toxicity effect of MS loaded Au@Ch-SF hydrogel was tested against cardiac myoblast H9C2 cells. Further, the tissue regenerative activities in myocardial infraction rats were examined by histology, apoptosis, and Cx43 cardiac-specific marker analysis.
Results
The gel formation time of Au@Ch-SF was comparatively lower than Ch and Ch-SF hydrogels which demonstrates the stronger intermolecular interactions between Ch and SF. The toxicity study showed that the prepared MS loaded Au@Ch-SF hydrogels did not possess toxicity against cardiac myoblast H9C2 cells. Further, the myocardial infarction rats were treated with MS loaded Au@Ch-SF hydrogel promotes the cardiac muscle fibers regeneration performance which was confirmed by β-MHC and Cx43 cardiac markers.
Conclusions
We demonstrate for the first time that encapsulation of MS with Au@Ch-SF hydrogels could promotes tissue regenerative activity in myocardial infraction tissues. The findings of this study suggest that MS encapsulated Au@Ch-SF hydrogels might be useful in the treatment of myocardial infarction.
Quantum theory cannot violate a causal inequality
Authors: Purves Tom , Short Anthony 
Published: April 2021

Abstract
Within quantum theory, we can create superpositions of different causal orders of events, and observe interference between them. This raises the question of whether quantum theory can produce results that would be impossible to replicate with any classical causal model, thereby violating a causal inequality. This would be a temporal analogue of Bell inequality violation, which proves that no local hidden variable model can replicate quantum results. However, unlike the case of non-locality, we show that quantum experiments can be simulated by a classical causal model, and therefore cannot violate a causal inequality.
Health-Related Quality of Life and Influencing Factors in Drug Addicts based on the scale QLICD-DA: A Cross-Sectional Study
Authors: Ma zilin , Liu yuxi , Wan chonghua , Jiang jianming , Li xiaomei , Zhang ying 
Published: April 2021

Abstract
BackgroundDrug abuse has many negative effects not only on individuals but also on society. Nowadays, researchers pay a lot of attention to the quality of life of drug-dependent persons. However, there are few scales available to measure the quality of life of people with substance-abuse disorders. A quality of life scale for patients with drug addiction/dependence (QLICD-DA) developed in China according to their actual situation could be used to measure the quality of life of drug abusers. It has good validity and reliability and is sensitive to the quality of life of drug-dependent persons. MethodsWe selected 192 drug-dependent persons as participants and they all completed the general information questionnaire and the QLICD-DA. We used a t-test to compare the scores of the quality of life of the participants with the norm in different domains, then we used one-way ANOVA to screen for variables. A stepwise regression method was applied to explore the influencing factors of the quality of life of the participants.ResultsThe quality of life of the participants was lower than the norm in the physiological domain, psychological domain, social domain, and common general domain, and the differences were statistically significant (p<.0.001). Sex and mode of drug abuse were the influencing factors in total score (p=0.006, p<0.001) and specific domain (p<0.001, p=0.019). Past family atmosphere and the mode of drug abuse were the influencing factors in the common general domain (p=0.027, p=0.037).ConclusionThe quality of life of people dependent on drugs was worse than that of patients with other chronic diseases, and the influencing factors of the quality of life of drug abusers were sex, mode of drug abuse, and past family atmosphere. This study also verified the application of QLICD-DA in a real-life setting.
Statin Use Is Associated With Reduced Mortality On Mechanically Ventilated Patients:A Retrospective Propensity-Matched Analysis
Authors: Chen Daonan , Wang Liu , Zhang Huifang , Lin Qiuhai , Tian Rui , Xu Jiyao , Miao Congliang , Huang Yuan , Ge Fangxia , Kang Mei , Zhu Yong , Xie Yun , Wang Ruilan , Du Jiang 
Published: April 2021

Abstract
BackgroundThe patients on mechanical ventilation were always critically ill and ventilation may cause injury and inflammatory disorders in the lungs of such patients. We sought to determine whether statin treatment has a protective effect on the outcome of the ventilated patients. MethodsA retrospective observational study of mechanically ventilated patients from the Medical Information Mart for Intensive Care III (MIMIC-III) database. To ensure the robustness of the findings, we utilized the gradient boosted model, propensity score analysis, doubly robust estimation and an inverse probability‐weighting model in the statistical procedure. The propensity score of statin use was calculated by age, sex, severity scores and 32 other variables. ResultsCompared with nonusers, the use of statins was associated with improved 28-day survival in the unmatched cohort (HR 0.85 95% CI 0.80~0.90, p<0.01) and matched cohort (HR 0.79 95% CI 0.73~0.85, p<0.01). Statin use was also associated with improved 60-day (HR 0.81 95%CI 0.75~0.85, p<0.01), 90-day (HR 0.81 95%CI 0.76~0.86, p<0.01) and in-hospital (HR 0.81 95%CI 0.76~0.86, p<0.01) survival in the matched cohort. Statins use was associated with longer ventilator free days (VFD28, 14.93±13.11 vs 12.06±13.26, p<0.01) and longer ICU free days (13.41±12.14 vs 10.86 ±12.19, p<0.01) in the matched cohort. Different types of statins were associated with improved 28-day survival. The subgroup analyses results showed improved 28-day survival in most subgroups, but this improvement was not observed in patients with pneumonia, septicemia or acute respiratory failure. ConclusionsIn a population of mechanically ventilated patients, the use of statins may be associated with reduced mortality. This protective effect was observed only in mild-to-moderate patients instead of critical inflammatory ones.Trial registrationhttp://www.chictr.org.cn/index.aspx; Registration number: ChiCTR2000029594
Persistent Homology on Electron Backscatter Diffraction Data in Nano/ultrafine-grained Metallic Materials
Authors: Na Gong , Farzana Nasrin , Yong Wang , Huibin Wu , David Keffer , Vasileios Maroulas , Orlando Rios 
Published: April 2021

Abstract
Nano/ultrafine-grained stainless steel was produced by severe cold deformation followed by annealing. The effect of annealing temperature on additional structural parameters, including the fraction of high-angle grain boundaries (HAGBs) and the kernel average misorientation (KAM), are revealed through electron backscatter diffraction. HAGB and KAM values provide a mechanistic understanding of the impact of structure on mechanical properties, including hardness, strength, and ductility. In this study, a novel application of persistent homology (PH) was employed to reduce the dimensionality of the information describing the complex processing-structure-property relationship. PH emphasizes the relationship between processing (annealing temperature), structure (distribution of the Schmid factor) and property (strength). Specifically, the PH formalism translates multidimensional data sets into clusters, distinguished by common PH features. In this analysis, two clusters emerge. First, at low annealing temperature, incomplete reversion of austenite results in materials with a greater fraction of grain boundaries, resulting in high strength and low ductility. Second, at high annealing temperature, fully reversed austenite results in lower, though still acceptable strength and superior ductility. The PH approach is applicable for identifying salient features in complex processing-structure-property relationships and is amenable to analysis of large data sets based on machine learning.
Impact of ICU saturation on hospital mortality from COVID-19 in a secondary care center in Iztapalapa, Mexico City
Authors: Alanís-Naranjo José Martín , Anguiano-Álvarez Víctor Manuel , Hammeken-Larrondo Eduardo Federico 
Published: April 2021

Abstract
INTRODUCTION: A saturated intensive care unit (ICU) setting and socioeconomic factors such as higher poverty rates have been associated with increased rates of in-hospital mortality in COVID-19 patients. Mexico City has become the national epicenter of the pandemic, with Mexico’s highest death toll. Iztapalapa is the delegation with the highest population density and the most notorious conditions of marginalization in Mexico City. We describe the clinical characteristics and risk factors associated with mortality in 164 patients who received care in a hospital ward setting due to ICU saturation in a hospital in Iztapalapa, Mexico City.MATERIALS AND METHODS: In this retrospective cohort study, data from confirmed COVID-19 patients hospitalized between April 1, 2020 and May 31, 2020 were collected. Patients were categorized into different subgroups: alive vs. deceased and intubated vs. nonintubated for analysis between groups. A p-value <0.05 was considered statistically significant.RESULTS: In this setting, 67% of the patients required mechanical ventilation, and 32.3% needed vasopressor support, with an in-hospital mortality of 68.3%. The most common complications during hospitalization were acute kidney injury (36%) and acute respiratory distress syndrome (34.8%). We observed similar factors associated with death as previous studies: male sex, older age, comorbidities, laboratory values indicating increased inflammatory/organ failure markers, and severe disease at admission. Additionally, we found that routine use of intravenous antibiotics was associated with a higher rate of in-hospital mortality (RR 3.45, 95% CI 1.69-7.06, p <0.001).
NCC-BCBM, a Nomogram Prognostic Model in Breast Cancer Patients with Bone Metastases
Authors: Zhai Jie , Liu Qiang , Bai Ping , Wang Zhongzhao , Fang Yi , Wang Jing 
Published: April 2021

Abstract
Purpose Accurate prediction tools to facilitate risk stratification and therapeutic strategies for breast cancer patients with bone metastasis (BCBM) are lacking. We constructed and validated a new nomogram prognostic model, named NCC-BCBM, for breast cancer patients with bone metastasis using a large BCBM cohort from the SEER (Surveillance Epidemiology and End Results) database. Patients and Methods Clinical information for 8655 patients diagnosed from 2011 to 2013 was collected to develop the nomogram prognostic model. The predictive accuracy and discriminative ability of the nomogram were evaluated by concordance index (C-index) and calibration curve. The model was further validated in an independent cohort of 4634 BCBM patients diagnosed from 2014 to 2015. Results The following clinical variables were enrolled in the final prognostic model: age, race, surgery, radiation therapy, chemotherapy, laterality, grade, molecular subtype, American Joint Committee on Cancer (AJCC T) stage, AJCC N stage and extra metastatic sites except bone. The C-index for the developed model in training cohort was 0.702 (95% CI, 0.696 to 0.709). The calibration curve for probability of 1-year, 3-year and 5-year survival showed good agreement between prediction by nomogram and direct observation. The prognostic model was validated in an independent validation cohort with a concordance index of 0.748 (95% CI, 0.737 to 0.759). Conclusion We developed and validated a nomogram prognostic model for BCBM patients and the proposed nomogram resulted in good performance.
Comparison of Bromocriptine and Hydroxyethyl Starch for Reducing Ohss in in Vitro Fertilization Patients: A Retrospective Study
Authors: Zhang Qiaoli , Ma Yanmin , Bu Xiaomeng , Jia Chanwei , Liu Yanjun , Wang Shuyu 
Published: April 2021

Abstract
Background: The ovarian hyperstimulation syndrome (OHSS) is a potentially life-threatening complication associated with controlled ovarian hyperstimulation (COS) during assisted reproductive technology (ART) treatment, and effective preventive measures are urgently needed. The dopamine agonist can mitigate OHSS incidence through a decreased vascular permeability via reduced vascular endothelial growth factor (VEGF) production. This study evaluated the clinical effectiveness of bromocriptine, an alternative DA, for prevention of OHSS in high risk women.Methods: The retrospective study population consisted of women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles with GnRH antagonist protocols, at risk of OHSS. The study group included 52 women given 2.5 mg bromocriptine daily by rectal insertion for 5 days beginning on the day of oocyte retrieval; the control group included 52 women given 500 ml intravenous (I.V.) hydroxyethyl starch (HES) daily for 5 days also beginning on the day of oocyte retrieval. The outcomes of ovarian stimulation, incidence and severity of OHSS, blood-related indicators, biochemical indicators (liver and renal function), and coagulation and fibrinolytic activities were compared.Results: The groups were not significantly different in age, estradiol concentration on the day of human chorionic gonadotropin injection, or number of retrieved oocytes. The occurrence of mild (13.46% vs 15.48%) and moderate (7.69% vs 5.77%) OHSS were not significantly different between bromocriptine and HES groups (P>0.05). No cases of severe or late OHSS were recorded in either group. Only hemocratin levels were significantly higher and activated partial thromboplastin time was significantly lower in the bromocriptine group (P<0.05) compared to the HES group on Day 5 after oocyte retrieval. No difference in liver or renal function was found between groups.Conclusions: Prophylactic rectal administration of bromocriptine was as effective as I.V. HES for prevention of OHSS.
Translation, Cross-Cultural Adaptation, and Psychometric Properties of the Malay-Translated Kihon Checklist Among Elderly Patients In The Emergency Department
Authors: Suhairi Suhaila Naema Laili , Embong Hashim , Ja Shamsuriani Md , Bakar Afliza Abu 
Published: April 2021

Abstract
BackgroundThe insufficiency of gold standard assessment tools is the current challenge of frailty detection in an emergency department (ED). This study aimed to translate and evaluate the psychometric properties of the Malay-translated Kihon Checklist (KCL) for frailty assessment among Malaysian elderly patients presenting to the ED.MethodThe 25-item English version of the KCL was translated to Malay language through a forward and backward translation procedure. Three expert panels considered the items and pilot-tested on 15 elderly subjects. The final version was administered to 250 elderly patients who presented in the ED. Using confirmatory factor analysis (CFA), we compared the prior factorial models of the KCL. Model fits were determined using the Chi-square test/degree of freedom (df), comparative fit index (CFI), Tucker–Lewis index (TLI), root mean square error of approximation (RMSEA), Akaike information criterion (AIC), Bayesian information criterion (BIC), and expected cross-validation index (ECVI).ResultsAnalysis revealed that none of the prior models (seven-, two-, and one-factorial model) fit the data. After modification, one-factor model with 10 items had a superior fit (Chi-square/df, 54.434/35; CFI, 0.962; TLI, 0.951; RMSEA, 0.047 (95% confidence interval (CI), 0.019–0.071); AIC, 94.434; BIC, 164.863; ECVI, 0.379). The internal consistency reliability for the pooled 10 items was acceptable, i.e., 0.786.ConclusionThe CFA revealed that a one-factor model with 10 items had superior goodness-of-fit than other hypothesized factorial models. The scale demonstrated adequate construct validity and acceptable reliability with caution interpretation of some items.
Intimate partner violence, spouse extramarital affairs, and depression among women in rural Uganda
Authors: Kaggwa Mark Mohan , Namatanzi Brenda , Kule Moses , Nkola Rahel , Najjuka Sarah Maria , Ashaba Scholastic 
Published: April 2021

Abstract
Background Depression is highly prevalent among women compared to men. Women in rural areas are more at risk of depression compared to their peers in urban areas. Some of the factors associated with depression among married women are spouse related factors including extramarital affairs and intimate partner violence (IPV).Objective To determine the prevalence of depression and factors associated with depression among married women in rural Southwestern Uganda.Methods This was a cross-sectional study in rural southwestern Uganda among married/cohabiting women aged 18 to 45 years. We used the Patient Health Questionnaire 9 (PHQ-9) to assess for depression, composite abuse scale (Revised) – Short Form (CASR-SF to measure IPV. Logistic regression was used to estimate the associations between depression and several factors including spouse extramarital affair, IPV, and sociodemographic factors.Results We enrolled 153 women, mean (standard deviation) age of 33.3 (6.7) and the majority were unemployed. The mean number of children between the couple was 4.05 (2.17). More than half (65,4%) had depressive symptoms and 64.1% had experienced intimate spouse violence. The reported spouses’ mean (SD) age was 43.4 (9.5). Almost half (49.65%) were known to be involved in an extramarital affair. There was a statically significant association between depression among women and spouse extramarital affairs (adjusted odds ratio (AOR) 24.93; 95% CI 1.25–498.34]; p-value = 0.04).Conclusion There was a high prevalence of depression and intimate partner violence among women in rural Uganda. The high prevalence was associated with spouse extramarital affairs. There should be routine screening for depression and intimate partner violence among married women at lower-level health facilities in rural settings especially those whose husbands are involved in extramarital affairs to ensure early diagnosis and access to appropriate mental health care to maintain functionality in society and family level since women are the backbone of their families.
Identification of Mirna Signature and Key Genes in Colorectal Cancer Lymph Node Metastasis
Authors: Wang Xi , Gao Guangyu , Chen Zhengrong , Chen Zhihao , Han Mingxiao , Xie Xiaolu , Jin Qiyuan , Du Hong , Cao Zhifei , Zhang Haifang 
Published: April 2021

Abstract
Background: miRNAs and mRNAs can serve as biomarkers for the diagnosis, prognosis and therapy of colorectal cancer (CRC), whose metastasis to lymph node is closely related to the poor prognosis. The current study aimed to identify the novel gene signatures in the lymph node metastasis of CRC.Methods: GSE56350, GSE70574 and GSE95109 were downloaded from the Gene Expression Omnibus (GEO) database and 569 colorectal cancer statistics were also downloaded from the The Cancer Genome Atlas (TCGA) database. Differentially expressed miRNAs (DE-miRNAs) were calculated by using R software. Besides, gene ontology and Enriched pathway analysis of target mRNAs were analyzed by using FunRich. Furthermore, the mRNA-miRNA network was constructed using Cytoscape software. Gene expression level was verified by GEO datasets and forty paired lymph node non-metastasis CRC tissues and lymph node metastatic CRC tissues obtained from patients with CRC using quantitative real-time PCR (qPCR) .Results: In total, five DE-miRNAs were selected, and 34 mRNAs were identified after filtering. Moreover, 2 key miRNAs and one gene were identified including hsa-miR-99a, has-miR-100 and heparan sulfate-glucosamine 3-sulfotransferase 2 (HS3ST2). The GEO datasets analysis and qPCR results showed the expression of key miRNA and genes were consistent with that in the bioinformatic analysis. A novel miRNA-mRNA network, hsa-miR-99a-HS3ST2-has-miR-100 was found in lymph node metastasis of CRC after expression analysis, prognostic prediction and experiments confirmation.Conclusions: In summary, the potential miRNAs and genes were found and a novel miRNA-mRNA network was established in CRC lymph node metastasis by systematic bioinformatic analysis and experiments validation, which may be used as potential biomarkers in the development of lymph node metastatic CRC.
Modification Of Reading Man Flap For Reconstruction Of Infraorbital Defects: a Case Report
Authors: Asparini Ruby Riana , Perdanakusuma David Sontani , Handajani Retno 
Published: April 2021

Abstract
Background: Reconstruction of the defect in the infraorbital area after wide excision can lead to problems such as distortion of the anatomical point and ectropion. A “reading man” flap is a recent local flap procedure, which has been used to treat this problem.Case Presentation: We report a case of keratotic basal cell carcinoma in the right infraorbital area. After wide excision, a defect of 40x35 mm was found, which was very close to the lid margin and close to the bottom of the eyebrow, which was reconstructed by reading man flap with slight modifications. Our modification is to extend the leg flap laterally, to avoid the lower part of the brow. So that the eyebrows are still protected from the flap incision.Conclusion: Reading man flap as a circular defect closure option is a useful addition to the plastic surgeon's mastery of techniques for performing round periorbital defect reconstruction. Reading man flap can be designed flexibly. It is a good option for the closure of round or elliptical-shaped defects.
Making Sense of Tweets Using Sentiment Analysis on Closely Related Topics
Authors: Bhatnagar Sarvesh , Choubey Nitin 
Published: April 2021

Abstract
Microblogging has taken a considerable upturn in recent years, with the growth of microblogging websites like Twitter people have started to share more of their opinions about various pressing issues on such online social networks. A broader understanding of the domain in question is required to make an informed decision. With this motivation, our study focuses on finding overall sentiments of related topics with reference to a given topic. We propose an architecture that combines sentiment analysis and community detection to get an overall sentiment of related topics. We apply that model on the following topics: shopping, politics, covid19 and electric vehicles to understand emerging trends, issues and its possible marketing, business and political implications.