bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Small-Dose S-Ketamine On Anesthesia-Induced Atelectasis In Patients Undergoing General Anesthesia Accessed By Lung Ultrasound: Study Protocol For A Randomized, Double-Blinded Controlled Trial
Authors: Zhang Di , Liang Yi , Bao Di , Xiong Wei , Li Lu , Wang Yaxin , Liu Bin , Jin Xu 
Published: June 2021

Abstract
Background: Aelectasis after anesthesia induction in most patients undergoing general anesthesia may lead to postoperative pulmonary complications (PPCs) and affect postoperative outcomes. However, there is still no existing effective method used for the prevention of perioperative atelectasis. S-ketamine may prevent atelectasis due to airway smooth muscle relaxation and anti-inflammatory effects. Lung ultrasound is a portable and reliable bedside imaging technology for diagnosing anesthesia-induced atelectasis. In this study, we aim to assess whether a small dose of S-ketamine can reduce the incidence of atelectasis after intubation under general anesthesia using lung ultrasound, in order to prevent the early formation of perioperative atelectasis and PPCs.Methods: This is a single-institution, prospective, randomized controlled, parallel grouping, and double-blind study. From October 2020 to March 2022, 100 patients (18-60 years old) scheduled for elective surgery will be recruited from Beijing Tiantan Hospital, Capital Medical University, and randomly assigned to the S-ketamine group (Group S) and the normal saline group (Group N) at a ratio of 1:1. The label-masked agents will be administered 5 min before induction, and all patients will undergo a standardized general anesthesia protocol. Related data will be collected at three-time points: after radial artery puncture (T1), 15 min after tracheal intubation (T2), and before extubation (T3). The primary outcome will be the total lung ultrasound scores (LUS) at T2. Secondary outcomes will include LUS in six chest regions at T2, total LUS at T3, arterial blood-gas analysis results (PaCO2, PaO2) and PaO2/FiO2 at T2 and T3, plateau pressure(Pplat) and dynamic lung compliance (Cdyn) at T2 and T3. The incidence of postoperative complications associated with S-ketamine and PPCs at 2 h and 24 h after surgery will be recorded.Discussion: This trial aims to explore whether a simple and feasible application of S-ketamine before the induction of general anesthesia can prevent atelectasis. The results of this study may provide new ideas and direct clinical evidence for the prevention and treatment of perioperative pulmonary complications during anesthesia.Trial registration: ClinicalTrials.gov identifier: NCT04745286.
A Lived Experience Co-Designed Study Protocol for a Randomised Control Trial: The Attempted Suicide Short Intervention Program (ASSIP) or Brief Cognitive Behavioural Therapy as Additional Interventions After a Suicide Attempt Compared to a Standard Suicide Prevention Pathway (SPP).
Authors: Stapelberg Nicolas JC , Bowman Candice , Woerwag-Mehta Sabine , Walker Sarah , Davis Angela , Hughes Ian , Michel Konrad , Pisani Anthony R , Engelen Heidy Van , Delos Mia , Hageman Tamara , Fullerton-Smith Kim , Krishnaiah Ravikumar , McDowell Sarah , Cameron Alison , Scales Trudy-Lee , Dillon Cherie , Gigante Titta , Heddle Cindy , Mudge Natalie , Zappa Anne , Edwards Michelle , Gutjahr Sigrun , Joshi Hitesh , Turner Kathyrn 
Published: June 2021

Abstract
Background

Despite being preventable, suicide is a leading cause of death and a major global public health problem. For every death by suicide, many more suicide attempts are undertaken, and this presents as a critical risk factor for suicide. Currently there are limited treatment options with limited underpinning research for those who present to Emergency Departments with suicidal behaviour. The aim of this study is to assess if adding one of two structured suicide specific psychological interventions (Attempted Suicide Short Intervention Program [ASSIP] or Brief Cognitive Behavioural Therapy [CBT] for Suicide Prevention) to a standardised clinical care approach (Suicide Prevention Pathway [SPP]) improves outcomes for consumers presenting to a Mental Health Service with a suicide attempt.
Methods

This is a randomised controlled trial with blinding of those assessing the outcomes. People who attempt suicide or experience suicidality after a suicide attempt, present to the Gold Coast Mental Health and Specialist Services, are placed on the Suicide Prevention Pathway (SPP) and meet the eligibility criteria, are offered the opportunity to participate. A total of 411 participants will be recruited for the study, with 137 allocated to each cohort (participants are randomised to SPP, ASSIP + SPP, or CBT + SPP). The primary outcomes of this study are re-presentation to hospital with suicide attempt and/or suicidal ideations. Death by suicide rates will also be examined. Self-reported level of suicidality, depression, anxiety, stress, resilience, problem-solving skills, self- and therapist-reported level of therapeutic engagement are also being examined. Psychometric data are collected at baseline, end of interventions, 6,12, and 24 months.
Discussion

This project will move both ASSIP and Brief CBT from efficacy to effectiveness research, with clear aims of assessing the addition of two structured psychological interventions to treatment as usual, providing a cost-benefit analysis of the interventions, thus delivering outcomes providing a clear pathway for rapid translation of successful interventions.
Trials registration

: NCT04072666 - Registered on 28th August 2019 on Clinical Trials US Gov (https://www.clinicaltrials.gov/ct2/show/NCT04072666?term=NCT04072666&draw=2&rank=1) and ANZCTR (https://www.anzctr.org.au/TrialSearch.aspx)
The Investigations of Atrial Fibrillation Burden after Cryoballoon Ablation Detected by Insertable Cardiac Monitor in Patients with Paroxysmal Atrial Fibrillation: A Study Protocol for a Multicenter Randomized Controlled Trial (Cryo-ICM AF study)
Authors: Luo Di , Liu Yanhong , zhang yue , Xu Gang , Liu Enzhao , Liu Tong , Li Guangping 
Published: June 2021

Abstract
Background: With the increasing number of aged population in China, the mortality and disability caused by atrial fibrillation (AF) and its complications lead to serious social burden and becoming more prominent. Due to the high false-negative rates of AF detected by routine ECG, the results on the recurrent rate and AF burden after cryoballoon ablation (CBA) in real world are inconsistent so far. Since the extension of monitoring time, the increased detection of AF in patients, insertable cardiac monitor (ICM) has its unique merits. Methods: Cryo-ICM AF study is a prospective, multicenter randomized controlled trial with 200 participants with paroxysmal atrial fibrillation from 4 centers. Monitoring AF load after CBA though two monitoring methods— ICM and 24 hours holter during the 1 years follow-up of the two groups. All data will be observed and recorded in baseline, 30th days and 3 th , 6 th , 9 th and 12 th months after CBA, which including incidence rates of postoperative complications and recurrence conditions, cardioelectrical indexes from 24-hours holter in all subjects and ICM in ICM group, UCG parameters about atrium/ventricular size and diastolic/systolic function, and biochemical indicators. Disucssion: This is the first study design to confirm the effectiveness of cryoballoon in real world, monitoring AF load with ICM in patients with paroxysmal AF after CBA.Trial registration: Chinese Clinical Trial Registry, No. ChiCTR1900026364. Registered 9 Oct 2019, http://www.chictr.org.cn/index.aspx
Impact of The Correlation Between Channel Input And Side Information On Physical Layer Security Performances of Wireless Wiretap Channel
Authors: Pakravan Saeid , Hodtani Ghosheh Abed 
Published: June 2021

Abstract
In this paper, a discrete memoryless wiretap channel with non-causal side information known at the encoder is considered. We (i) characterize capacity region for the Gaussian version of this channel by considering correlation between channel input and side information available at the transmitter; (ii) analyze the impact of correlation on the performance of physical layer security in a Rayleigh fading wiretap channel by deriving closed-form expressions on the average secrecy capacity (ASC) and secrecy outage probability (SOP). Further, to more show the impact of side information, asymptotic behavior of SOP is studied. Numerical evaluation of theoretical results is done finally.
Human muscle stem/progenitor cells are bi-potential adult stem cells
Authors: Shao Xiexiang , Fu Xin , Han Lili , Li Sheng , Wang Hongye , Zhou Shenao , Wang Jianhua , Hu Ping 
Published: June 2021

Abstract
Tendon injury occurs at high frequency and is difficult to repair. Identification human stem cells being able to regenerate tendon will greatly facilitate the development of regenerative medicine for tendon injury. We identified human muscle stem/progenitor cells having tendon differentiation potential both in vitro and in vivo. Interestingly, the tendon differentiation potential is not present in mouse muscle stem cells. These findings reveal that human muscle stem cells are bi-potential adult stem cells and can serve as a new source for tendon regeneration.
Evaluation of Events of Extreme Temperature Change between Neighboring Days in CMIP6 Models over China
Authors: Song Shuaifeng , Yan Xiaodong 
Published: June 2021

Abstract
In the context of global warming, the frequency and intensity of extreme weather and climate events are increasing. However, the impact of these changes that is directly felt by people is the day-to-day temperature change. Extreme temperature changes between neighboring days (ETCNs) carry substantial disease risks and socioeconomic impacts. Evaluative studies of ETCN events with global circulation models (GCMs) remain unknown in China. This study quantitatively evaluates the performances of 36 GCMs and the multi-model ensemble (MME) of the Coupled Model Intercomparison Project 6 (CMIP6) in simulating the extreme cooling (EC) and extreme warming (EW) events of two consecutive days as defined by relative thresholds. Moreover, we select the optimal models in different regions at the seasonal and annual scales in China, providing theoretical support for the frequency projection and modeling improvement of ETCN events. The results showed that from 1981 to 2013, the annual average EW events and EC events in China showed increasing but not statistically significant trends, and the frequency of EW events was higher than that of EC events. EW events mostly occurred in spring, while EC events mostly occurred in autumn. Additionally, the performances of the CMIP6 models are quite different between EC and EW events. The simulations of EC events are generally more reliable than those of EW events, and the models can also capture the annual cycle of EC events well. Furthermore, the CMIP6 models overestimate the frequencies of EW and EC events but underestimate the frequency of EC events in autumn. The CMIP6 models exhibit poor performance in simulating the trend of and interannual variability in ETCN events and can only simulate the decreasing trend in autumn. Finally, according to the overall ranking of the CMIP6 models, GFDL-ESSM4 and EC-Earth3-Veg-LR achieve the best performance in simulating EW and EC events, respectively. The CMIP6 MME only effectively improved the capabilities of the models to simulate winter EC events in the WNW region. In terms of the trend of and interannual variability in ETCN events, individual models exhibited better performances than the CMIP6 ensemble.
The Identification and Analysis of a Novel Model Based on Ferroptosis-Related Genes for Predicting the Prognosis of Diffuse Large B-Cell Lymphomas
Authors: Wang Jiayi , Peng Hongling , Zhang Guangsen , Xu Yunxiao , Yan Wenzhe 
Published: June 2021

Abstract
Backgroud: Diffuse large B-cell lymphomas (DLBCLs) are featured as phenotypically and genetically heterogeneous. Ferroptosis is a newly discovered regulated cell death pathway that plays a crucial role in the occurrence and progression of tumors. We aim to identify a ferroptosis-related gene (FRG) prognostic signature for DLBCLs by systematic analysis of transcriptional profiles. Methods: This study retrospectively analysed the transcriptome profiles and clinical parameters of 604 DLBCL patients from 3 public datasets. A series of bioinformatic approaches including univariate and multivariate Cox regression analysis, function analysis, immune infiltration analysis, differential expression analysis, ROC curve analysis, Kaplan–Meier survival curve and the least absolute shrinkage and selection operator (LASSO) method by the corresponding R packages in R software were combined to explored the heterogenicity of FRG based clusters and to built prognostic model. Immunohistochemistry was used to exam the protein expression of six FRGs in different type of DLBCL.Results: We first identified 19 FRGs with potential prognostic values and classfied the patients into two subgroups (named cluster 1 and cluster 2), Results showed that there were different patterns of immune cell infiltration among patients in the two clusters. Furthermore, the LASSO was used to generated a six genes (GCLC, LPCAT3, NFE2L2, ABCC1, SLC1A5, and GOT1) risk signature which constructed a risk score formula and prognostic model for the overall survival (OS) of DLBCL patients. Kaplan–Meier survival analysis proved that poorer OS was exhibited in higher risk patients stratified by the prognostic model in both the training cohort and test cohort. In addtion, we constructed nomograms to predict the OS of DLBCL patients. Both the decision curve(DCA) and the calibration plots showed that the nomogram had good predictive performance. Finally, the validation by immunohistochemistry indicated the GCLC, LPCAT3, NFE2L2, SLC1A5, and GOT1 were high expressed in DLBCL with various prognostic adverse molecular factor. Conclusion: In sum, we built a new FRG-based prognostic model which will help improve diagnosis and treatment for DLBCL patients.
GLRX5-associated [Fe-S] Cluster Biogenesis Disorder: Further Characterisation of the Neurological Phenotype and Long-term Outcome.
Authors: Sankaran Bindu Parayil , Gupta Sachin , Tchan Michel , Devanapalli Beena , Rahman Yusof , Procopis Peter , Bhattacharya Kaustuv 
Published: June 2021

Abstract
Background: Identification and characterisation of monogenic causes of complex neurological phenotypes are important for genetic counselling and prognostication. Bi-allelic pathogenic variants in the gene encoding GLRX5, a protein involved in the early steps of Fe-S cluster biogenesis, are rare and cause two distinct phenotypes: isolated sideroblastic anemia and a neurological phenotype with variant non-ketotic hyperglycinemia. In this study, we analysed the evolution of clinical and MRI findings and long-term outcome of patients with GLRX5 mutations. Methods: Four patients from three Australian families of Lebanese descent were identified. All patients presented in childhood and were followed up into adult life through multiple clinical assessments. All were prescribed sodium benzoate.Results: All patients (all females, age range 18-56 years) showed a complex neurological phenotype characterised by varying combinations of spastic paraparesis, length-dependent motor/ sensory-motor axonal polyneuropathy, and psychiatric disturbances with variable intellectual disability. All had non-ketotic hyperglycinemia and a homozygous pathogenic c.151_153delAAG (p.K51del) change in GLRX5. Motor disability gradually progressed reaching moderate disability during adolescence and moderately severe disability during adult life. The major MRI finding was the upper cervical spinal cord signal changes with contrast enhancement noted in all and additional leukoencephalopathy in one. On follow up MRI, the white matter lesions diminished on a subsequent scan and then remained static over time. The spinal cord showed gliotic changes. Two patients have previously demonstrated low pyruvate dehydrogenase complex deficiency but none had plasma lactate elevation, nor biochemical evidence of branch-chain keto-dehydrogenase deficiency. Glycine levels reduced in patients that tolerated sodium benzoate, possibly stabilising clinical manifestations.Conclusion: This report demonstrates that the p.K51del GLRX5 variant causes a distinct and predictable neurological phenotype. The clinical assessments spanning from childhood to adult life enable physicians to infer the natural history of GLRX5 related neurological disorder. There may be widespread metabolic consequences, and optimal management is unknown.
Understanding vaccine hesitancy with application of Latent Dirichlet Allocation to Reddit Corpora
Authors: Duraivel Samuel , R Lavanya 
Published: June 2021

Abstract
This research paper explores the underlying factors that contribute toward vaccine hesitancy, resistance, and refusal. Using Latent Dirichlet Allocation (LDA), an unsupervised generative-probabilistic model, we generated latent topics from user generated Reddit corpora on reasons for Vaccine hesitancy. Although we hoped to explore the grounds for vaccine hesitancy across the globe, our findings suggest that the corpus used for analysis had been generated by users living predominantly in the United States.Observation of the topics generated by the LDA model led to the discovery of the following latent factors: (i) fear of risks and side effects, (ii) lack of trust in policymakers, (iii) related to religious belief, (iv) related to mass surveillance theories, (v) perception of vaccination as a precedence to totalitarianism, (vi) racial background pertaining to retrospective events of racial injustice, such as selective sterilization, (vii) depopulation agenda fueled by theories affiliated to Global warming and extinction rebellion, (viii) and perception of vaccination as a campaign to quell immigrant population growth, fueled by reports of coerced sterilization of immigrants in the ICE detention.
Pollution Resistance Assessment of Plants Around Chromite Mine Based on Anticipated Performance Index, Dust Capturing Capacity and Metal Accumulation Index
Authors: Mandal Kalicharan , Dhal Nabin Kumar 
Published: June 2021

Abstract
Plant species sustaining under a polluted environment for long time are considered as potentially resistant species. Those plant species can be considered as an eco-sustainable tool used to bio-monitor and mitigate pollution. This study was carried out on total ten commonly available plant species to assess their anticipated performance index (API), Dust capturing capacity (DCC) and Metal accumulation index (MAI) in chromite mine and control area. According to Anticipated performance index (API) Macranga peltata, Holarrhena pubescens and Ficus hispida are highly tolerant species while Terminalia arjuna and Trema orientalis are intermediate tolerant species. Ficus hispida was also showed the highest dust capturing capacity (5.94 ± 0.43 mg/cm2) and whereas Woodfordia fruticosa (1.03 ± 0.11 mg/cm2) was found to be lowest. Metal accumulation index ranged from 17.29 to 4.5 and 6.38 to 1.94 at mine and control area respectively. Two-way ANOVA analysis revealed area wise significant differences between biochemical and physiological parameters. Also, result showed that the pollution level and heavy metal affected different biochemical and physiological parameter of plant species at mining area. The plant species with highest API, DCC and MAI value could be recommended for greenbelt development in different polluted area.
Newly Discovered Tuff in the Lower Shaximiao Formation in Yunyang, Chongqing, Southwestern China and Its Constraint on the Burial Age of the Yunyang Dinosaur Fauna
Authors: Zhou Yuxuan , Yang Wenguang , Dai Hui , Zhang Hongliang , Hu Xufeng , Li Deliang , Yu Haidong , Zhu Lidong , Tan Chao , Li Ning 
Published: June 2021

Abstract
The Shaximiao Formation is one of the important Mesozoic burial horizons of dinosaur fossils in the Sichuan Basin. Although a large number of research results on the stratigraphic age of the Shaximiao Formation have been published, the age and division of the Shaximiao Formation are still controversial. To a certain extent, this affects the precise constraints on the burial age of the dinosaur fauna in Yunyang, Chongqing. In this study, the newly discovered tuff intercalation in the Lower Shaximiao Formation in Pu'an Township, Yunyang County, Chongqing City, was taken as the research object, and its lithology and formation age were determined using thin section identification, X-ray diffraction (XRD), scanning electron microscopy (SEM), and U-Pb zircon dating. The field observations and thin section microscopic characteristics of the rocks reveal that the clay rock intercalation has a typical sedimentary tuff structure, which is altered lithic tuff. The SEM imaging and XRD results indicate that it has a typical tuff mineral composition. The U-Pb zircon dating shows that the weighted average age of the newly discovered tuff is 174.8 ± 2.4 Ma, and the burial age of the dinosaur fossils is estimated to be 174.7 ± 2.4 Ma based on the sedimentation rate and the thickness of the stratum.
Key words: Sichuan Basin; Shaximiao Formation; Yunyang Dinosaur Fauna; Tuff; Burial Age
Molecular Characterization of β-Lactamase Producing Genes and Integrons in Diarrheagenic Escherichia Coli From Diarrheal Children Less Than Five Years of Age in Ouagadougou, Burkina Faso.
Authors: Dembele Rene , Kaboré Wendpoulomdé A.D. , Soulama Issiaka , Traoré Oumar , Ouédraogo Nafissatou , Konaté Ali , Guessennd Nathalie K , N’Golo David Coulibaly , Sanou Antoine , Serme Samuel , Zongo Soumanaba , Sampo Emmanuel , Traoré Alfred S. , Gassama-Sow Amy , Barro Nicolas 
Published: June 2021

Abstract
Background

The aim of this study was to determine the resistance of diarrheagenic Escherichia coli strains to β-lactams antibiotics and to perform the molecular characterization of Extended Spectrum β-lactamases (ESBL) and integrons genes.
Methods

This study was carried out from August 2013 to October 2015 and involved 31 DEC strains isolated from diarrheal stools samples collected from children less than five years of age. The identification and characterization of DEC strains was done through the standard biochemical tests those were confirmed using API 20E and Polymerase Chain Reaction (PCR). The determination of antimicrobial resistance was realized by the disk diffusion method then an amplification of the β-lactamase resistance genes and integrons by PCR was done.
Results

Out of the 419 E. coli strains identified, 31 isolates (7.4%) harbored the DEC virulence genes. From these DEC, 21 (67.7%) were ESBL-producing E. coli. Susceptibility to ESBL-producing E. coli showed that the majority of isolates were highly resistant to amoxicillin (77.4%), amoxicillin clavulanic acid (77.4%) and piperacillin (64.5%). The following antibiotic resistance genes and integron were identified from the 31 DEC isolates: blaTEM (6.5%), blaSHV (19.4%), blaOXA (38.7%) blaCTX−M (9.7%), Int1 (58.1%) and Int3 (19.4%). No class 2 integrons (Int2) was characterized.
Conclusions

Because of the high prevalence of multidrug-resistant ESBL organisms found in this study among pediatric patients, there is a need of stringent pediatric infection control measures.