bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Treatment of Unidentified Hematotoxic Snake Envenomation and the Clinical Manifestations of a Protobothrops kelomohy Bite
Authors: Tangtermpong Athitarn , Pinyopornpanish Kanokporn , Vasaruchapong Taksa , Chenthanakij Boriboon , Pinyopornpanish Kanokwan 
Published: January 2021

Hematotoxic snake envenomation is clinically important and has serious complications. This case report describes the clinical manifestations of a bite from a newly described species of hematotoxic snake and the outcomes of treatment using locally available antivenom and supportive management. A 39-y-old male was bitten on his right ankle by an unidentified snake. The patient developed coagulopathy, rhabdomyolysis, and clinical signs of compartment syndrome of his right leg within the first day. Eight doses (30 mL, or 3 vials per dose), or a total of 240 mL, of hemato-polyvalent antivenin (Thai Red Cross, Thailand) were given. Aggressive intravenous hydration and alkalinization of urine were performed, and a fasciotomy was performed for the treatment of suspected compartment syndrome. The patient’s clinical symptoms and laboratory results indicated progressive improvement during the 5 d of hospitalization. The snake was later identified as Protobothrops kelomohy, a novel snake species with no clinical data available regarding its envenomation of humans. This case shows that P kelomohy envenomation can produce severe effects that occur both locally and systemically. The benefits of the use of polyvalent antivenom in this situation were unclear. However, with supportive treatment in conjunction with serial clinical and laboratory monitoring, the patient recovered, albeit after 7 d of hospitalization.
Peer-to-Peer Lending and EU Credit Laws: A Creditworthiness Assessment, Credit-Risk Analysis or … Neither of the Two?
Authors: Ferretti Federico 
Published: January 2021

AbstractThe Article deals with the protection of consumer borrowers and lending investors in peer-to-peer lending within the legal framework provided by EU credit laws. This is the legal framework for EU Member States in the area of loans to consumers. In particular, the article analyses the business model of taking lending decisions on financial technologies (“Fintech”) and big data vis-à-vis the legal obligation of the creditworthiness assessment by lenders. At the same time, it extends the applicability of such a business model to the credit-risk analysis undertaken in the interest of lenders. Ultimately, it questions to what extent EU law caters for peer-to-peer lending, and and to what extent consumers and lenders can find protection. It hints that peer-to-peer lending presents risks for both consumers and lenders, falling short of legal obligations and established practices for their protection.
Enlarging the Immunities of European Parliament’s Members: The Junqueras Judgment
Authors: Torre de Silva Victor 
Published: January 2021

AbstractMembers of Parliament have traditionally enjoyed different kinds of immunities; nowadays, these are openly criticized on several grounds. The Court of Justice of the European Union (CJEU) has recently given a judgment on the inviolability of European Parliament’s members, which might be regarded as a milestone in its scarce case law on the matter: Oriol Junqueras Vies, Judgment of the Grand Chamber of December 19, 2019. This Article intends to summarize and comment on this decision, a preliminary reference requested by the Spanish Supreme Court in a notorious criminal procedure, connected with the suspended referendum on Catalonia’s independence. The CJEU reinforces the inviolability of Members of European Parliament (MEPs), thus strengthening the powers of this institution. However, the judgment perhaps fails to fully capture European Court of Human Rights (ECtHR) case law and was rendered at a time when the controversy on Mr. Junqueras had arguably become outdated.
The Place of Labor Rights in the European Union’s Environmental Policies
Authors: McDougall Pascal 
Published: January 2021

AbstractThis Article analyzes the potential impact of the European Commission’s proposed “European Green Deal” on labor rights, in particular the rights of workers in lower-income EU Member States. It focuses on environmental measures, already part of the EU’s existing environmental policies and further contemplated in the Green Deal, which prohibit or tax certain polluting production processes. Such measures, insofar as they apply uniformly to traded-good industries, are likely to make firms in lower-income EU Member States less competitive and harm their workers’ rights to work and to fair wages. Thus, even though these environmental measures are worth pursuing for the benefits they procure, the distribution of their costs is likely to run afoul of egalitarian norms. This Article puts forward an institutionalist approach to trade theory which recognizes that competitiveness is legally constructed. It argues on the basis of that theory that lower-income countries should be allowed to adopt ambitious industrial policies and subsidize their firms to insulate workers from the disruptions caused by added environmental regulatory costs. More broadly, this Article presents an agenda to pursue radical environmental transformation while remedying, or at least not worsening, inequalities between workers and citizens in the EU.
Legal Lobbying: The Evolving (But Hidden) Role of Lawyers and Law Firms in the EU Public Affairs Market
Authors: Korkea-aho Emilia 
Published: January 2021

AbstractThere is an increasing involvement of lawyers and law firms in public affairs through activities that are aimed at influencing legislative and regulatory developments. Law firms offer services which can be regarded as lobbying, and yet, to the detriment of transparent policy-making, they are reluctant to register in the European Union Transparency Register (EUTR) and provide information about their activities. As growing attention is paid to the need to regulate lobbying at the EU and Member State levels, the question arises as to whether and to what extent such regulatory framework should also cover certain services provided by law firms, that is, legal lobbying. This Article charts the phenomenon of legal lobbying and its regulation in the EU context. It shows how the EUTR attempts to distinguish between legal services and lobbying by defining two lawyer roles: a legal expert, and an advocate. These roles allow the possibility to pinpoint two unresolved issues associated with legal lobbying: the scope of professional secrecy, and the meaning of the legal advice exception. An important conclusion is that regulatory clarification is necessary to resolve ambiguities and broadly address the implications that legal lobbying raises in terms of transparent and legitimate law-making processes.
Resolving the Inconsistency Between National and EU Motor Insurance Law. Was Factortame the Solution Nobody Sought?
Authors: Marson James , Alissa Hasan , Ferris Katy 
Published: January 2021

AbstractIn this Article, we argue that the uncertainty of UK national motor vehicle insurance law—when viewed with respect to its European Union (EU) parent, the Motor Vehicle Insurance Directive (MVID)—was never satisfactorily addressed, primarily when using the remedy available through the non-contractual liability of the State. The EU enforcement mechanisms were equally haphazard in their effectiveness and success in affording rights to third-party victims. Given the link between the MVID and the free movement of persons and goods, on which the harmonization of insurance protection was based, we present the first Article establishing an argument that those offending aspects of UK national law should have been disapplied. The UK has concluded its agreement to withdraw its membership of the EU—and thus no longer to be bound by EU law and the jurisprudence of the Court of Justice. Yet until the transitional period ends, the UK remained aligned to EU law and those defects present in national law should have been remedied. Therefore, the remedy issued from the Factortame line of case authorities may have proven to be the most effective way to grant access to rights which were denied to third-party victims in the UK. Here we present a justification for its application.
Intelligence quotient decline following frequent or dependent cannabis use in youth: a systematic review and meta-analysis of longitudinal studies
Authors: Power Emmet , Sabherwal Sophie , Healy Colm , O’ Neill Aisling , Cotter David , Cannon Mary 
Published: January 2021

AbstractPrevious systematic reviews and meta-analyses of cross-sectional data assessing the effect of cannabis on cognitive functioning and intelligence show inconsistent results. We hypothesized that frequent and dependent cannabis use in youth would be associated with Intelligence Quotient (IQ) decline. This study is a systematic review and meta-analysis. We searched Embase, PubMed and PsychInfo from inception to 24 January 2020. We included studies with non-treatment seeking samples and pre- and post-exposure measures of IQ. We requested data from authors if summary data was not available from published work. We preregistered our review with PROSPERO (ID no. CRD42019125624). We found seven cohort studies including 808 cases and 5308 controls. We found a significant effect for the association between frequent or dependent cannabis use in youth and IQ change, Cohen's d = −0.132 (95% CI −0.198 to −0.066) p < 0.001. Statistical heterogeneity between studies was also low at I2 = 0.2%. Study quality was moderate to high. This translates to an average decline of approximately 2 IQ points following exposure to cannabis in youth. Future studies should have longer periods of follow up to assess the magnitude of developmental impact.
A generic model for representing openness in multi-agent systems
Authors: Hattab Sondes , Lejouad Chaari Wided 
Published: January 2021

Abstract
Openness is a challenging property that may characterize multi-agent systems (MAS). It refers to their ability to deal with entities leaving and joining agent society over time. This property makes the MAS behaviour complex and difficult to study and analyze, hence the need for a representative model allowing its understanding. In this context, many models were defined in the literature and we propose to classify them into three categories: structural models, functional models and interactional models. The existing models were proposed either for representing structural openness or for modelling functional or interactional ones independently. But, none of them was oriented to represent MAS openness in a global way while considering its three aspects at once. Besides, each one was defined in order to realize a specific objective and in a particular domain of application. In this paper, we propose an evolving KAGR graph. The latter provides a common understanding of openness and unifies its structural, functional and interactional aspects in a generic way. Our model is finally tested and validated on a multi-agent rescue simulator.
Do TV viewing and frequency of ultra-processed food consumption share mediators in relation to adolescent anxiety-induced sleep disturbance?
Authors: Werneck André O , Hoare Erin , Silva Danilo R 
Published: January 2021

AbstractObjective:To investigate the role of potential shared mediators in the association of TV viewing and frequency of ultra-processed food consumption with anxiety-induced sleep disturbance.Design:Cross-sectional study.Setting:Data from the Adolescent School-Based Health Survey, a Brazilian nationally representative survey of ninth-grade adolescents conducted in 2015, were used.Participants:99 791 adolescents (52 015 girls) with a mean age of 14·3 years (range 11–19) participated. All variables were collected through a self-reported questionnaire based on the Global School-Based Student Health Survey. Anxiety-induced sleep disturbance was the outcome. Over 4 h/d of TV viewing and daily consumption of ultra-processed foods were the exposures. Body satisfaction, loneliness, self-rated health and eating while watching TV or studying were mediators. Age, ethnicity, food insecurity, type of city (capital or interior), country region and physical activity were covariates. Logistic regression and mediation models (Karlsson–Holm–Breen method) assessed associations.Results:Both daily ultra-processed food consumption (boys: OR 1·48, 95 % CI 1·30, 1·70; girls: OR 1·46, 95 % CI 1·34, 1·60) and TV viewing (boys: OR 1 24, 95 % CI 1·08, 1·43; girls: OR 1·09, 95 % CI 1·00, 1·19) were associated with higher odds for anxiety-induced sleep disturbance. Loneliness and eating while watching TV or studying (only among girls) consistently mediated the association of both daily ultra-processed food consumption (loneliness: boys 17·4 %, girls 23·4 %; eat while watching TV or studying: girls 6·8 %) and TV viewing (loneliness: boys 22·9 %, girls 45·8 %; eat while watching TV or studying: boys 6·7 %, girls 17·9 %) with anxiety-induced sleep disturbance.Conclusions:Daily ultra-processed food consumption and TV viewing share mediators and can act in synergic mechanisms in the association with anxiety-induced sleep disturbance. Therefore, future interventions should focus in the reduction of both behaviours in combination.
Declining Summertime pCO2 in Tundra Lakes in a Granitic Landscape
Authors: Brothers S. , Bowes D. , Pearse W. D. , Tank S. , Vanengen R. , Sibley P. 
Published: January 2021

AbstractAs climate change accelerates, positive feedback loops could establish between atmospheric warming and increasing greenhouse gas (GHG) emissions from natural ecosystems. Of particular interest are high‐latitude environments, many of which contain large stores of organic carbon and have experienced decades of accelerated warming. Freshwater ecosystems situated in carbon‐rich Arctic landscapes are predicted to respond to warming with higher respiration rates relative to primary production rates, increasing their carbon dioxide partial pressure (pCO2) and thus CO2 emissions to the atmosphere. However, large areas of shallow soil/bedrock occur in Arctic and sub‐Arctic regions and could respond differently due to the lower availability of stored carbon. Here, we used pH and alkalinity to calculate 23 years (1994–2017) of summertime (July and August) pCO2 and CO2 fluxes for 19 sub‐Arctic tundra lakes located on the shallow‐bedrock granitic Canadian Shield in Nunavut, Canada, and found a significant decline in CO2 emissions. Regional precipitation did not change over this period, yet dramatic increases in pH, conductivity, and total alkalinity indicated that longer ice‐free periods and changes in primary production, both functions of accelerated climate warming at higher latitudes, may be suppressing lacustrine CO2 emissions. Northern lakes overlying differing geological landscapes may thus be responding in contrasting ways in terms of pCO2 and CO2 fluxes, with potential major implications for regional carbon budgets and predicted climate change feedbacks.
Thallium Isotopes Reveal Brine Activity During Carbonatite Magmatism
Authors: Horton Forrest , Nielsen Sune , Shu Yunchao , Gagnon Alan , Blusztajn Jerzy 
Published: January 2021

AbstractCarbonatite volcanism remains poorly understood compared to silicic volcanism due to the scarcity of carbonatite volcanoes worldwide and because volcanic H2O and CO2—major components in carbonatite volcanic systems—are not well preserved in the rock record. To further our understanding of carbonatite genesis, we utilize the non‐traditional thallium (Tl) isotope system in Khanneshin carbonatites in Afghanistan. These carbonatites contain 250–30,000 ng/g Tl and have ε205Tl values (−4.6 to +4.6) that span much of the terrestrial igneous range. We observe that δ18OVSMOW (+8.6‰ to +23.5‰) correlates positively with δ13CVPDB (−4.6‰ to +3.5‰) and ε205Tl up to δ18O = 15‰. Rayleigh fractionation of calcite from an immiscible CO2‐H2O fluid with a mantle‐like starting composition can explain the δ18O and δ13C—but not ε205Tl—trends. Biotite fractionates Tl isotopes in other magmatic settings, so we hypothesize that a Tl‐rich hydrous brine caused potassic metasomatism (i.e., biotite fenitization) of wall rock that increased the ε205Tl of the residual magma‐fluid reservoir. Our results imply that, in carbonatitic volcanic systems, simultaneous igneous differentiation and potassic metasomatism increase ε205Tl, δ18O, δ13C, and light rare earth element concentrations in residual fluids. Our fractionation models suggest that the Tl isotopic compositions of the primary magmas were among the isotopically lightest (less than or equal to ε205Tl = −4.6) material derived from the mantle for which Tl isotopic constraints exist. If so, the ultimate source of Tl in Khanneshin lavas—and perhaps carbonatites elsewhere—may be recycled ocean crust.
Observations of Secondary Magnetic Reconnection in the Turbulent Reconnection Outflow
Authors: Zhou M. , Man H. Y. , Deng X. H. , Pang Y. , Khotyaintsev Y. , Lapenta G. , Yi Y. Y. , Zhong Z. H. , Ma W. Q. 
Published: January 2021

AbstractMagnetic reconnection and turbulence are the two most important energy dissipation processes in plasma. These two processes intertwine with each other and play important roles in their respective dynamic evolution. Here, we present the first evidence that secondary reconnections occur in the turbulent outflow driven by a primary reconnection in the Earth's magnetotail. We have identified 14 secondary reconnections in a large number of current filaments in the turbulent outflow, which persisted for about one and half an hour. Most of these secondary reconnections were electron‐only reconnection that has recently been discovered in the magnetosheath. These secondary reconnections entangled the magnetic field lines and dissipated the magnetic energy in the outflow region far away from the primary X line.
Arbitrary polarization conversion dichroism metasurfaces for all-in-one full Poincaré sphere polarizers
Authors: Wang Shuai , Deng Zi-Lan , Wang Yujie , Zhou Qingbin , Wang Xiaolei , Cao Yaoyu , Guan Bai-Ou , Xiao Shumin , Li Xiangping 
Published: January 2021

AbstractThe control of polarization, an essential property of light, is of broad scientific and technological interest. Polarizers are indispensable optical elements for direct polarization generation. However, arbitrary polarization generation, except that of common linear and circular polarization, relies heavily on bulky optical components such as cascading linear polarizers and waveplates. Here, we present an effective strategy for designing all-in-one full Poincaré sphere polarizers based on perfect arbitrary polarization conversion dichroism and implement it in a monolayer all-dielectric metasurface. This strategy allows preferential transmission and conversion of one polarization state located at an arbitrary position on the Poincaré sphere to its handedness-flipped state while completely blocking its orthogonal state. In contrast to previous methods that were limited to only linear or circular polarization, our method manifests perfect dichroism of nearly 100% in theory and greater than 90% experimentally for arbitrary polarization states. By leveraging this attractive dichroism, our demonstration of the generation of polarization beams located at an arbitrary position on a Poincaré sphere directly from unpolarized light can substantially extend the scope of meta-optics and dramatically promote state-of-the-art nanophotonic devices.
Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis
Authors: Wang Lijun , Yang Huiliang , Huang Jiahui , Pei Shaopeng , Wang Liyun , Feng Jian Q. , Jing Dian , Zhao Hu , Kronenberg Henry M. , Moore Douglas C. , Yang Wentian 
Published: January 2021

AbstractThe maturation and function of osteoblasts (OBs) rely heavily on the reversible phosphorylation of signaling proteins. To date, most of the work in OBs has focused on phosphorylation by tyrosyl kinases, but little has been revealed about dephosphorylation by protein tyrosine phosphatases (PTPases). SHP2 (encoded by PTPN11) is a ubiquitously expressed PTPase. PTPN11 mutations are associated with both bone and cartilage manifestations in patients with Noonan syndrome (NS) and metachondromatosis (MC), although the underlying mechanisms remain elusive. Here, we report that SHP2 deletion in bone gamma-carboxyglutamate protein-expressing (Bglap+) bone cells leads to massive osteopenia in both trabecular and cortical bones due to the failure of bone cell maturation and enhanced osteoclast activity, and its deletion in Bglap+ chondrocytes results in the onset of enchondroma and osteochondroma in aged mice with increased tubular bone length. Mechanistically, SHP2 was found to be required for osteoblastic differentiation by promoting RUNX2/OSTERIX signaling and for the suppression of osteoclastogenesis by inhibiting STAT3-mediated RANKL production by osteoblasts and osteocytes. These findings are likely to explain the compromised skeletal system in NS and MC patients and to inform the development of novel therapeutics to combat skeletal disorders.
DAMPs released by pyroptotic cells as major contributors and therapeutic targets for CAR-T-related toxicities
Authors: Deng Tian , Tang Chao , Zhang Guizhong , Wan Xiaochun 
Published: January 2021

AbstractCAR-T transfer, recently well-developed immunotherapy, has offered substantial benefit to more and more patients with advanced cancers. However, along with growing experience in the clinical application comes the increasing awareness of the potentially fatal adverse effects, most notably cytokine release syndrome (CRS) and neurotoxicity. Understanding the mechanisms underlying these toxicities can help to improve therapeutic outcomes. Recent findings highlight the importance of monocyte/macrophage in CAR-T-related toxicities (CARTOX) and shed light on a novel mechanism mediated by damage-associated molecular patterns (DAMPs) released from pyroptotic cells. Therefore, this review summarizes these findings and provides practical guidance to the management of CARTOX.
Synthesis, antibacterial action, and ribosome inhibition of deoxyspectinomycins
Authors: Dharuman Suresh , Wilt Laura A. , Liu Jiuyu , Reeve Stephanie M. , Thompson Carl W. , Elmore John M. , Shcherbakov Dimitri , Lee Robin B. , Böttger Erik C. , Lee Richard E. 
Published: January 2021

AbstractSpectinomycin, an aminocyclitol antibiotic, is subject to inactivation by aminoglycoside modifying enzymes (AMEs) through adenylylation or phosphorylation of the 6-hydroxy group position. In this study, the effects of deoxygenation of the 2- and 6-hydroxy group positions on the spectinomycin actinamine ring are probed to evaluate their relationship to ribosomal binding and the antimicrobial activities of spectinomycin, semisynthetic aminomethyl spectinomycins (amSPCs), and spectinamides. To generate these analogs, an improved synthesis of 6-deoxyspectinomycin was developed using the Barton deoxygenation reaction. 6-Dehydrospectinamide was also synthesized from spectinamide 4 to evaluate the H-bond acceptor character on the C-6 position. All the synthesized analogs were tested for antibacterial activity against a panel of Gram (+) and Gram (−) pathogens, plus Mycobacterium tuberculosis. The molecular contribution of the 2- and 6-hydroxy group and the aryl functionalities of all analogs were examined by measuring inhibition of ribosomal translation and molecular dynamics experiments with MM/GBSA analysis. The results of this work indicate that the 6-hydroxy group, which is the primary target of AMEs, is a required motif for antimicrobial activity in current analogs. Removal of the 6-hydroxy group could be partially rescued by offsetting ribosomal binding contributions made by the aryl side chains found in the spectinamide and amSPCs. This study builds on the knowledge of the structure–activity relationships of spectinomycin analogs and is being used to aid the design of next-generation spectinomycins.