bluuebunny/crossref_metadata_2025_split huggingface dataset:
The surgical resection of dysplastic cerebellar gangliocytoma assisted by intraoperative sonography: illustrative case
Authors: Li Yiming , Guo Jiahe , Wei Huijie , Sun Cuiyun , Chai Yan , Fu Xiuwei , Zhang Kai , Yu Shengping , Yang Xuejun 
Published: October 2021

BACKGROUND
Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease) is an extremely rare, slow-growing hereditary mass lesion that is mainly characterized by both specific neuroradiological features and secondary hydrocephalus. Patients may present with symptoms of cerebellar mass lesion and increased intracranial pressure. As an important part of Cowden syndrome, Lhermitte-Duclos disease in adults is typically marked by PTEN gene mutation.

OBSERVATIONS
The clinical management of a 31-year-old woman who suffered Lhermitte-Duclos disease was introduced in this case report. Subtotal resection was performed with the assistance of intraoperative sonography to relieve obstructive hydrocephalus, and prophylactic C1 laminectomy was performed to prevent possible postoperative progression of the residual lesion. Perioperative care and surgical process were clearly revealed in an accompanying video. Intraoperative sonography of Lhermitte-Duclos disease presents hyperechoic distorted thickening cortices surrounded by hypoechoic edema belt. The patient did not report any significant neurological complications or sequelae after the lesion resection.

LESSONS
The authors first reported the use of intraoperative sonography in resection of adult-onset Lhermitte-Duclos disease. Hopefully, the educative case report can provide a feasible experience in the diagnosis and treatment of Lhermitte-Duclos disease.
Trauma, Gender, Love, and Teen Drama
Authors: Labuhn Lauren Nicole , Klimenko Marina 
Published: October 2021

Research suggests that past trauma can contribute to the downfall of long-term romantic partnerships. This study implemented a content analysis of a television show 13 Reasons Why to examine the realism of the depiction of adolescents’ romantic attitudes and quality of relationships. The show is intended to depict real, unfiltered experiences of adolescents in today’s society. The specific goal of the present study was to examine the relationship between the depictions of adolescents’ romantic expressions and their experiences with trauma. Additionally, the study examined differences in the depiction of romantic expressions based on the gender of the characters. Statistical analyses revealed that past traumatic experience was the only significant predictor of romantic expressions. Specifically, characters who had experienced the most trauma were the least likely to express romantic ideals.
PEMANFAATAN URIN KELINCI SEBAGAI PUPUK ORGANIK CAIR (POC) UNTUK MENINGKATKAN PRODUKSI DAN PENDAPATAN USAHA TANI JAGUNG MANIS (Zea mays saccharata Sturt)
Authors: Miyana Harahap  
Published: October 2021

Jagung manis (Zea mays saccharata Sturt) merupakan salah satu jenis tanaman yang dipanen muda dan banyak diusahakan di daerah tropis. Jagung manis atau sering disebut sweet corn dikenal di Indonesia pada awal tahun 1980 dan merupakan salah satu komoditas sumber pangan yang penting, karena jagung manis memiliki nilai gizi yang berbeda dengan jagung biasa. Kandungan yang terdapat pada jagung manis antara lain 70,7% karbohidrat, 13,5 % air, 10,0 % protein, 0,4 % lemak dan zat-zat lain. Salah satu teknologi yang dapat digunakan untuk meningkatkan produksi dan pendapatan usaha tani jagung manis adalah urin kelinci sebagai pupuk organik cair (POC). Pengaplikasian POC urin kelinci dapat meningkatkan hasil jagung manis sebesar 173 kg/125 m2 (13,84 ton/ha), sedangkan produksi jagung manis tanpa POC urin kelinci adalah 129 kg/125 m2 (10,32 ton/ha). Pengaplikasian POC urin kelinci meningkatkan pendapatan usaha tani dengan R/C ratio lebih tinggi yaitu 1.83, profitabilitas 83.7% dibandingkan dengan tanpa POC urin kelinci yaitu sebesar 1.70 dengan profitabilitas 70
KOMPETISI TANAMAN KANGKUNG (Ipomoea aquatica) DENGAN GULMA SEMBUNG RAMBAT (Mikania micrantha H.B.K.)
Authors: Srima Ningsih Mismawarni 
Published: October 2021

Abstrak

Sembung rambat merupakan tanaman introduksi yang memiliki daya invasi tinggi, sehingga menjadi gulma di pertanaman kangkung. Penelitian ini bertujuan untuk melihat pengaruh kompetisi antara gulma sembung rambat dengan tanaman kangkung. Menggunakan metode penelitian eksperimen dengan Rancangan Acak Lengkap 5x5. Perlakuan yang diberikan adalah (A) Kangkung, (B) Kangkung + 1 Sembung rambat, (C) Kangkung + 2 Sembung rambat, (D) Kangkung + 3 Sembung rambat, (E) Kangkung + 4 Sembung rambat. Bila perlakuan mempengaruhi hasil kangkung, analisis dilanjutkan dengan uji lanjut Duncan New Multiple Range Test (DNMRT) pada taraf 5%. Hasil menunjukan keberadaan sembung rambat di pertanaman kangkung darat dapat menurunkan tinggi, jumlah daun, diameter batang dan bobot kering kangkung. Penurunan semakain besar dengan bertambahnya jumlah sembung rambat pada pertanaman akibat terjadinya kompetisi terhadap faktor lingkungan yang sama. Dari penelitian dapat disimpulkan bahwa sembung rambat yang berada di pertanaman kangkung merupakan gulma yang dapat menurunkan hasil panen dan keberadaannya dipertanaman harus dikendalikan.
UJI DAYA HASIL PADA JAGUNG HIBRIDA, KOMPOSIT DAN LOKAL DI PARIAMAN
Authors: Dewi Riska Kurnia 
Published: October 2021

Pariaman memiliki potensi produksi jagung yang tinggi untuk memenuhi permintaan jagung di Sumatera Barat yang terus meningkat. Tujuan penelitian ini adalah untuk mendapatkan jenis varietas jagung yang memiliki daya hasil tinggi di Pariaman. Percobaan ini dilakukan di Kota Pariaman Sumatera Barat, dengan ketinggian +/- 32 mdpl yang berlangsung dari bulan November 2020 s/d April 2021. Rancangan percobaan yang digunakan adalah Rancangan Acak Lengkap (RAL) satu faktor yaitu 10 varietas jagung, V1= Bima 20, V2= JH-37, V3= Nasa 29, V4= Pioneer P32, V5= NK, V6= Bisi 18, V7= Sinhas, V8= Sukmaraga, V9= Galur IBF, dan V10= Lokal Agam. Hasil penelitian ini adalah Jagung hibrida varietas Pioneer P32 menunjukkan hasil yang tinggi dengan berat tongkol tanpa kelobot 16.08 ton/ha.
PENERAPAN PEMBELAJARAN NUMBERED HEADS TOGETHER UNTUK MENINGKATKAN HASIL BELAJAR PESERTA DIDIK MATA PELAJARAN FISIKA TENTANG MEDAN MAGNET DI KELAS XI TKP B SMKN 2 BOGOR
Authors: Simamora Tangunan 
Published: October 2021

<p>Penelitian ini bertujuan untuk : (1) Untuk mengetahui model pembelajaran Collaboration<em> Type Numbered Heads Together ( NHT ) </em> dapat meningkatkan hasil belajar peserta didik tentang Medan Magnet di Kelas X TKP B Semester 1 Tahun Pelajaran 2020 - 2021 SMK Negeri 2 Kota Bogor, (2) Untuk mendeskripsikan proses peningkatkan hasil belajar peserta didik tentang Medan Magnet sebelum dan sesudah menggunakan model pembelajaran Collaboration <em>Type Numbered Heads Together (NHT) </em> di Kelas X TKP B Semester 1 Tahun Pelajaran 2020 - 2021 SMK Negeri 2 Kota Bogor,(3) Untuk mengukur besarnya peningkatan hasil belajar peserta didik tentang Medan Magnet setelah menggunakan menggunakan model pembelajaran Collaboration <em>Type Numbered Heads Together (NHT) </em> di Kelas X TKP B Semester 1 Tahun Pelajaran 2020 - 2021 SMK Negeri 2 Kota Bogor. Hasil penelitian ini menunjukan bahwa dengan menggunakan Penggunaan model pembelajaran <em>Type Numbered Heads Together (NHT)</em> membuat peserta didik tidak bosan dan jenuh sebaliknya merasa senang sehingga aktivitas belajar mereka meningkat. Hal ini terbukti pada siklus I ada 55,55% atau 20 peserta didik yang aktif, 22,22% atau 8 peserta didik yang cukup aktif dan 22,22% atau 8 peserta didik yang kurang aktif pada saat pembelajaran. Setelah guru memperbaiki hasil refleksi pada siklus I maka pada siklus II didapat 77,77% atau 28 peserta didik aktif pada saat pembelajaran dan 22,22% atau 8 peserta tidak yang cukup aktif pada saat pembelajaran serta 0,00% atau tidak ada peserta didik yang tidak aktif pada saat pembelajaran. Hal tersebut berpengaruh terhadap hasil belajar yang dicapai peserta didik Model pembelajaran <em>Type Numbered Heads Together (NHT)</em> dapat meningkatan hasil belajar pesertsa didik pada tentang Medan Magnet di kelas X TKP B SMK Negeri 2 Bogor dengan menggunakan model pembelajaran <em>Type Numbered Heads Together (NHT)</em>.</p>
Optimization of culture media to produce Bacillus subtilis strain QST 713 in a handcrafted bioreactor
Authors: Valera- Montero L.L. , González-Delgadillo L. , Amador-Rodríguez K. A. , Perales-Segovia C. , Flores Benítez Silvia 
Published: October 2021

Objective. To optimize a nutrient medium based on fertilizers for the cultivation of Bacillus subtilis in an Airlift-type handcrafted bioreactor.
Design/Methodology/Approach. Twenty-seven nutrient media, fixed by combining five factors with three levels, including sucrose, ammonium sulfate, triple superphosphate, UltraK® formula, and B. subtilis inoculum (Serenade® Max) were tested in a 50L handcrafted by the authors. The variables monitored in the media were absorbance, dissolved oxygen, pH, and temperature. The first was the one that was considered for optimization as it is the indirect indicator of bacterial growth. On the statistical analysis, the option "Larger is better" was chosen for Signal/Noise for the ANOVA of the main effects according to the Taguchi method.
Results. The highest level of sucrose, together with the lowest level of triple superphosphate were determinants for maximum growth of Bacillus in the time studied. On the other hand, the components such as ammonium sulfate, UltraK® formula, or the amount of inoculum were not significant, which means that they can be added from the mid to low levels.
Study limitations/Implications. This new information can be scaled to bioreactors of 2500 L for B. subtilis that we have previously developed.
Finding/Conclusions. Maximum bacterial growth depends on a good supply of sucrose, limiting triple superphosphate. Additionally, it is prudent to decrease additions of ammonium sulfate because it reduces dissolved oxygen in the nutrient medium.
Online-Based Learning: Challenges and Strategies of Freshman Language Learners
Authors: Barrera Danica Jane 
Published: October 2021

The increasing demand for the implementation of an alternative learning scheme to aid the sudden setback in the field of education has been one of the most debated topics among the government and educational sectors worldwide. With the impossibility of face-to-face learning, the government had to devise an attainable learning substitution plan which resulted in the birth of online education. This study is one of the few studies that seek to determine the challenges and strategies used by freshman language learners in online education in the midst of a pandemic. Furthermore, a descriptive-qualitative design was employed in the study. Hence, the data were gathered using semi-structured interviews. The respondents for this study were identified by means of a purposive sampling technique. On that account, the respondents were handpicked in consideration to the inclusion criteria. Moreover, in depth individual interviews were conducted to seven respondents, five females and 2 males. To analyze the data, thematic analysis was utilized. The challenges that emerged in the study are the following: High-cost internet access, less social engagement and inactive class discussion, unfamiliarity of the new learning modality, internet connectivity, stress inducing school-works, lack of technological resources, location-related stressors and unpredictability of power outages. The paper concludes with the four emerging themes concerning the strategies freshman language learners use in online education and how those strategies aid the aforementioned challenges.
Analisa Kualitas Layanan Website PT. Masusskita United Menggunakan Metode Webqual
Authors: Faza Audina , Utomo Agus Prasetyo 
Published: October 2021

Abstrak - PT MASUSSKITA UNITED adalah sebuah perusahaan yang bergerak dibidang Heavy Duty Industry. Peningkatan informasi melalui pemanfaatan website selaras perkembangan teknologi saat ini. Website perusahaan yang telah diimplementasikan menjadi pendorong dalam upaya meningkatkan informasi produk, namun seiring perkembangan kebutuhan perusahaan yang bertambah, dibutuhkan analisa untuk mengukur kualitas layanan website yang diharapkan mampu mendongkrak pelayanan dan penjualan secara maksimal kepada pengunjung website. Metode webqual digunakan untuk mengukur kualitas layanan website yang berdomain www.masusskita.co.id dengan menggunakan metode Webqual, dan penelitian ini bertujuan untuk mengetahui kualitas kepuasan layanan website PT Masusskita United. Metode pengumpulan data menggunakan kuesioner dan memperoleh 161 responden. Pengolahan data statistik menggunakan SmartPLS 3.0. Hasil dari uji hipotesis yang menunjukan bahwa dari 5 hipotesis hanya 4 yang memiliki pengaruh yang signifikan dan 1 tidak signifikan. Secara bersama-sama Variable Usability, User Interface, Service Interaction berpengaruh terhadap variabel E-Cutomer Satisfaction, dan Pengaruh positif dan adanya pengaruh signifikan Variabel E-Customer terhadap variabel E-Customer Loyalty. Namun pengaruh variable Information Quality tidak signifikan terhadap variable E-Customer Satisfaction.
Ring D-Modified and Highly Reduced Angucyclinones From Marine Sediment-Derived Streptomyces sp.
Authors: Guo Lin , Yang Qiaoli , Wang Guangfei , Zhang Shumin , Liu Ming , Pan Xiaohong , Pescitelli Gennaro , Xie Zeping 
Published: October 2021

Angucyclines and angucyclinones represent the largest family of type II PKS-engineered natural products. Chemical analysis of a marine Streptomyces sp. KCB-132 yielded three new members, actetrophenone A (1) and actetrophenols A–B (2–3). Their structures were elucidated by NMR spectroscopy, X-ray crystallography and CD calculations. Actetrophenone A (1) is the first representative of a novel-type angucyclinone bearing a nonaromatic D-ring. Actetrophenol A (2) features a highly reduced and aromatized four-ring system, which is unprecedented for natural products. While (Ra)- and (Sa)-actetrophenol B (3) bear an unprecedented N-acetyltryptamine-substituted tetraphene core skeleton, this is the first report of a pair of atropisomeric isomers in the angucyclinone family. Actetrophenol A (2) exhibits remarkable antibiotic activity, notably including potent activity to multiple resistant Staphylococcus aureus and Enterococcus faecium with MIC values of 4 μg/ml, in contrast, the positive control antimicrobial agent penicillin was inactive up to 32 μg/ml.
Analysis of Salivary Mycobiome in a Cohort of Oral Squamous Cell Carcinoma Patients From Sudan Identifies Higher Salivary Carriage of Malassezia as an Independent and Favorable Predictor of Overall Survival
Authors: Mohamed Nazar , Litlekalsøy Jorunn , Ahmed Israa Abdulrahman , Martinsen Einar Marius Hjellestad , Furriol Jessica , Javier-Lopez Ruben , Elsheikh Mariam , Gaafar Nuha Mohamed , Morgado Luis , Mundra Sunil , Johannessen Anne Christine , Osman Tarig Al-Hadi , Nginamau Elisabeth Sivy , Suleiman Ahmed , Costea Daniela Elena 
Published: October 2021

BackgroundMicrobial dysbiosis and microbiome-induced inflammation have emerged as important factors in oral squamous cell carcinoma (OSCC) tumorigenesis during the last two decades. However, the “rare biosphere” of the oral microbiome, including fungi, has been sparsely investigated. This study aimed to characterize the salivary mycobiome in a prospective Sudanese cohort of OSCC patients and to explore patterns of diversities associated with overall survival (OS).Materials and MethodsUnstimulated saliva samples (n = 72) were collected from patients diagnosed with OSCC (n = 59) and from non-OSCC control volunteers (n = 13). DNA was extracted using a combined enzymatic–mechanical extraction protocol. The salivary mycobiome was assessed using a next-generation sequencing (NGS)-based methodology by amplifying the ITS2 region. The impact of the abundance of different fungal genera on the survival of OSCC patients was analyzed using Kaplan–Meier and Cox regression survival analyses (SPPS).ResultsSixteen genera were identified exclusively in the saliva of OSCC patients. Candida, Malassezia, Saccharomyces, Aspergillus, and Cyberlindnera were the most relatively abundant fungal genera in both groups and showed higher abundance in OSCC patients. Kaplan–Meier survival analysis showed higher salivary carriage of the Candida genus significantly associated with poor OS of OSCC patients (Breslow test: p = 0.043). In contrast, the higher salivary carriage of Malassezia showed a significant association with favorable OS in OSCC patients (Breslow test: p = 0.039). The Cox proportional hazards multiple regression model was applied to adjust the salivary carriage of both Candida and Malassezia according to age (p = 0.029) and identified the genus Malassezia as an independent predictor of OS (hazard ratio = 0.383, 95% CI = 0.16–0.93, p = 0.03).ConclusionThe fungal compositional patterns in saliva from OSCC patients were different from those of individuals without OSCC. The fungal genus Malassezia was identified as a putative prognostic biomarker and therapeutic target for OSCC.
Association of Serum Biomarkers and Cardiac Inflammation in Patients With Atrial Fibrillation: Identification by Positron Emission Tomography
Authors: Chen Bi-Xi , Xie Boqia , Zhou Yang , Shi Liang , Wang Yanjiang , Zeng Lijun , Liu Xingpeng , Yang Min-Fu 
Published: October 2021

Background: Peripheral biomarkers may be affected by various factors, their reliability in reflecting local cardiac inflammatory status in patients with atrial fibrillation (AF) needs further exploration. This prospective study was aimed to investigate the relationship between circulating biomarkers and local cardiac inflammation measured by epicardial adipose tissue (EAT) activity via18F-fluorodeoxyglucose (FDG) imaging in AF patients.Methods: From 2017 to 2018, 83 AF patients [43 persistent AF (PsAF) and 40 paroxysmal AF (PAF)] referred for radiofrequency catheter ablation (RFCA) were recruited. Pre- and post-RFCA blood samples were collected to measure IL-6, IL-8, IL-10, IL-18, TNF-α, Hsp27, Hsp60, Hsp70, PDGF-BB, MMP-2, MMP-9, MPO, TGF-β1, Gal-3, and sST2. Pre-RFCA FDG images were obtained to assess EAT activity. Sixty-seven patients (35 PAF and 32 PsAF) received RFCA were regularly followed for 27 (24, 29) months.Results: Higher hsCRP and IL-6 and lower TGF-β1 were demonstrated in PsAF patients compared with PAF patients. Multivariate logistic regression analysis demonstrated that Gal-3 (OR: 1.221, 95% CI: 1.024–1.456, P = 0.026) and MPO (OR: 1.002, 95% CI: 1.001–1.003, P = 0.027) were independently correlated with EAT activity. The percentage decrease of Hsp60 linearly correlated with that of EAT activity post-RFCA (Spearman rs = 0.455, P = 0.019). Seventeen patients (10 PsAF and 7 PAF) had AF recurrence, but none of the selected biomarkers were predictive of post-RFCA recurrence.Conclusion: Our findings demonstrated that in patients with AF, Gal-3 correlated with local cardiac inflammation, and Hsp60 was associated with the alleviation of cardiac inflammation after RFCA.
LOX-1 Deletion Attenuates Myocardial Fibrosis in the Aged Mice, Particularly Those With Hypertension
Authors: Li Xiao , Tang Xihe , Liu Bo , Zhang Jinghang , Zhang Yongxi , Lv Hefan , Liu Dongling , Mehta Jawahar L. , Wang Xianwei 
Published: October 2021

Background: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a transmembrane glycoprotein that mediates uptake of oxidized low-density lipoprotein (ox-LDL) into cells. Previous studies had shown that LOX-1 deletion had a potential to inhibit cardiac fibrosis in mouse models of hypertension and myocardial infarction. Whether LOX-1 deletion also affects cardiac fibrosis associated with aging still remains unknown. The aim of this study was to investigate the effect of LOX-1 deletion on myocardial fibrosis in the aged mice.Methods: C57BL/6 mice and LOX-1 knockout (KO) mice with C57BL/6 background were studied to the age of 60 weeks. Both genotypes of aged mice were exposed to angiotensin II (Ang II) or saline for additional 4 weeks. The mice were then sacrificed, and myocardial fibrosis, reactive oxygen species (ROS) and expression of LOX-1, fibronectin, collagens, p22phox, and gp91phox were measured.Results: LOX-1 deletion markedly reduced Ang II-mediated rise of blood pressure in the aged mice (vs. saline-treated mice). LOX-1 deletion also limited fibrosis and decreased fibronectin and collagen-3 expression in the hearts of aged mice, but not the expression of collagen-1 and collagen-4. LOX-1 deletion also inhibited ROS production and p22phox expression. As the aged mice were exposed to Ang II for 4 weeks (resulting in hypertension), LOX-1 deletion more pronounced inhibiting myocardial fibrosis and ROS production, and decreasing expression of fibronectin, collagen-1, collagen-2, collagen-3, p22phox, and gp91phox.Conclusion: LOX-1 deletion limited fibrosis and ROS production in the hearts of aged mice. This effect was more pronounced in the aged mice with hypertension induced by Ang II infusion.
Obesity Phenotypes and Electrocardiographic Characteristics in Physically Active Males: CHIEF Study
Authors: Lin Yu-Kai , Tsai Kun-Zhe , Han Chih-Lu , Lin Yen-Po , Lee Jiunn-Tay , Lin Gen-Min 
Published: October 2021

Background: Metabolically unhealthy obesity (MUO) has been associated with surface electrocardiographic (ECG) left ventricular hypertrophy (LVH), left atrial enlargement (LAE), and inferior T wave inversions (TWI) in the middle- and old-aged populations. However, the relationship between obesity phenotypes and these ECG abnormalities in physically active young adults is yet to be determined.Methods: A total of 2,156 physically active military males aged 18–50 in Taiwan were analyzed. Obesity and metabolically unhealthy status were, respectively, defined as the body mass index ≥27 kg/m2 and the presence of metabolic syndrome based on the ATPIII criteria for Asian male adults. Four groups were classified as the metabolically healthy non-obesity (MHNO, n = 1,484), metabolically unhealthy non-obesity (MUNO, n = 86), metabolically healthy obesity (MHO, n = 376), and MUO (n = 210). ECG-LVH was based on the Sokolow–Lyon and Cornell voltage criteria, ECG-LAE was defined as a notched P wave ≥0.12 s in lead II or a notch of ≥0.04 s, and inferior TWI was defined as one negative T wave axis in limb leads II, III, or aVF. Physical performance was evaluated by time for a 3-km run. Multiple logistic regression analysis with adjustment for age, smoking, alcohol drinking, and physical performance was utilized to investigate the associations between obesity phenotypes and the ECG abnormalities.Results: As compared to MHNO, MUNO, MHO, and MUO were associated with lower risk of Sokolow–Lyon-based ECG-LVH [odds ratios (OR) and 95% confidence intervals: 0.80 (0.51–1.25), 0.46 (0.36–0.58), and 0.39 (0.28–0.53), respectively; p for trend &lt;0.001], and with greater risk of ECG-LAE [OR: 0.87 (0.44–1.72), 2.34 (1.77–3.10), and 3.02 (2.13–4.28), respectively; p for trend &lt;0.001] and inferior TWI [OR: 2.21 (0.74–6.58), 3.49 (1.97–6.19), and 4.52 (2.38–8.60), respectively; p for trend &lt;0.001]. However, no associations between obesity phenotypes and Cornell-based ECG-LVH were found.Conclusion: In physically active young males, obesity was associated with higher risk of ECG-LAE and inferior TWI, whereas the risk between obesity and ECG-LVH might vary by the ECG criteria, possibly due to a high prevalence of exercise induced-LVH in military and greater chest wall thickness in obesity. The cardiovascular prognosis of ECG-LVH in physically active obese adults requires further study.