bluuebunny/crossref_metadata_2025_split huggingface dataset:
Judgement of the multidisciplinary team is an important predictor of mortality after cardiac resynchronization therapy
Authors: Passos Luiz Carlos Santana , Viana Tainá Teixeira , Carvalho William , Grimaldi Aline , Roriz Pollianna , Figueiredo Clara , Nascimento Thais , Vieira de Melo Rodrigo Morel 
Published: October 2021

AbstractAimsCardiac resynchronization therapy (CRT) in appropriately selected patients with heart failure improves symptoms and survival. It is necessary to correctly identify patients who will benefit most from this therapy. We aimed to assess the predictive power of the multidisciplinary team's clinical judgement in the short‐term death after CRT implantation.Methods and resultsPatients with heart failure and referred for the first CRT implant were prospectively included. Prior to implantation, all patients underwent a systematic assessment with a team composed of social work, nurse, psychologist, nutritionist, and clinical cardiologist. Based on this assessment, patients could be contraindicated to CRT or referred to the procedure as favourable or unfavourable. All patients should complete 12 months of follow‐up; 172 patients were referred for CRT, 21 (12.2%) were contraindicated after the multidisciplinary team evaluation, 71 (47%) referred to CRT as non‐favourable implants, and 80 (53%) as favourable implants. All‐cause mortality occurred in only 2 (2.5%) patients in the favourable group and in 30 (42.3%) in the non‐favourable group, P < 0.001 (log rank). Among the 20 variables used as possible predictors of worse prognosis by the multidisciplinary team, four were independently associated with mortality in the follow‐up after the multivariate analysis: 1 year MAGGIC score between 40% and 49%, relative risk (RR) 5.0, 95% confidence interval (CI) 1.3–18.6, P = 0.016; poor pharmacological adherence, RR 4.9, 95% CI 1.6–15.6, P = 0.007; glomerular filtration rate <35 mL/min/1.73 m2, RR 3.0, 95% CI 1.1–8.5, P = 0.041; and right ventricular dysfunction, RR 2.6, 95% CI 1.2–5.7, P = 0.018.ConclusionsThe clinical judgement before the CRT implantation performed by a multidisciplinary team through the analysis of clinical and psychosocial variables is a strong predictor of short‐term mortality.
The interaction of delayed retirement initiative and the multilevel social health insurance system on physical health of older people in China
Authors: Yuan Bocong , Li Jiannan , Liang Wenqi 
Published: October 2021

AbstractWith many social challenges posed by an ageing population, the delayed retirement initiative has received wide attention from policymakers. However, China's current multi‐level social health insurance system seems not perfect and not ready for the delayed retirement initiative. The public are generally concerned that the benefits of late retirees cannot be well guaranteed. Using data from China Health and Retirement Longitudinal Study (CHARLS) and the chorological design (CHARLS‐2015 and ‐2018 waves), this study finds that (1) late retirement could be beneficial for physical health among older adults; (2) there have disparities between the effects of different social health insurances on physical health among older adults; (3) social health insurances could weaken the benefits of late retirement to physical health among older adults. Results imply that China's current multi‐level social medical insurance system may lag behind the proposed delayed retirement initiative and have policy limitations for late retirees.
Targeting microRNA for improved skin health
Authors: Li Xi , Ponandai‐Srinivasan Sakthi , Nandakumar Kutty Selva , Fabre Susanne , Xu Landén Ning , Mavon Alain , Khmaladze Ia 
Published: October 2021

AbstractBackgroundIn human skin, miRNAs have important regulatory roles and are involved in the development, morphogenesis, and maintenance by influencing cell proliferation, differentiation, immune regulation, and wound healing. MiRNAs have been investigated for many years in various skin disorders such as atopic dermatitis, psoriasis, as well as malignant tumors. Only during recent times, cosmeceutical use of molecules/natural active ingredients to regulate miRNA expression for significant advances in skin health/care product development was recognized.AimTo review miRNAs with the potential to maintain and boost skin health and avoid premature aging by improving barrier function, preventing photoaging, hyperpigmentation, and chronological aging/senescence.MethodsMost of the cited articles were found through literature search on PubMed. The main search criteria was a keyword “skin” in combination with the following words: miRNA, photoaging, UV, barrier, aging, exposome, acne, wound healing, pigmentation, pollution, and senescence. Most of the articles reviewed for relevancy were published during the past 10 years.ResultsAll results are summarized in Figure 1, and they are based on cited references.ConclusionsThus, regulating miRNAs expression is a promising approach for novel therapy not only for targeting skin diseases but also for cosmeceutical interventions aiming to boost skin health.
The impacts of R&D investment and stock markets on clean‐energy consumption and CO2 emissions in OECD economies
Authors: Alam Md Samsul , Apergis Nicholas , Paramati Sudharshan Reddy , Fang Jianchun 
Published: October 2021

AbstractThe goal of this paper is to examine to what extent R&D investment and stock market development promote clean‐energy consumption and environmental protection across a panel of 30 OECD economies. Based on the theoretical approach, study employs robust panel econometric models, which account for cross‐sectional dependence in the analysis and uses annual data, spanning the period 1996–2013. The empirical results illustrate that R&D and stock market have a significant long‐run equilibrium relationship with clean energy and CO2 emissions. The long‐run elasticities display that R&D and stock market growth have a significant positive impact on clean‐energy consumption, while they have a negative effect on the growth of CO2 emissions. Given these findings, the paper suggests that the policy makers in the OECD economies should realize that it is worth investing in R&D activities as it is promoting the use of clean energy and ensuring low carbon economies. Therefore, the policymakers have to initiate effective policies to promote R&D activities and also encourage the firms that are listed in the stock market to adopt environmental friendly policies.
Mental health and resilience during the coronavirus pandemic: A machine learning approach
Authors: Samuelson Kristin W. , Dixon Kelly , Jordan Joshua T. , Powers Tyler , Sonderman Samantha , Brickman Sophie 
Published: October 2021

AbstractObjectiveThis study explored risk and resilience factors of mental health functioning during the coronavirus disease (COVID‐19) pandemic.MethodsA sample of 467 adults (M age = 33.14, 63.6% female) reported on mental health (depression, anxiety, posttraumatic stress disorder [PTSD], and somatic symptoms), demands and impacts of COVID‐19, resources (e.g., social support, health care access), demographics, and psychosocial resilience factors.ResultsDepression, anxiety, and PTSD rates were 44%, 36%, and 23%, respectively. Supervised machine learning models identified psychosocial factors as the primary significant predictors across outcomes. Greater trauma coping self‐efficacy and forward‐focused coping, but not trauma‐focused coping, were associated with better mental health. When accounting for psychosocial resilience factors, few external resources and demographic variables emerged as significant predictors.ConclusionWith ongoing stressors and traumas, employing coping strategies that emphasize distraction over trauma processing may be warranted. Clinical and community outreach efforts should target trauma coping self‐efficacy to bolster resilience during a pandemic.
Highly efficient synthesis and NMR features of novel fused pyrimidothiazinium trihalogenides
Authors: Onysko Mikhajlo , Svalyavin Oleg , Slivka Marina , Slivka Mikhailo , Baumer Vjacheslav , Lendel Vasil 
Published: October 2021

AbstractCondensed pyrimidines are a popular class of heterocyclic compounds because they have a wide range of biological activity. This article aims to evaluate the simple, catalyst‐free procedure of synthesis of novel fused pyrimidothiazines. An efficient access to a series of pyrazolo[4′,3′:5,6]pyrimido[2,1‐b][1,3]thiazinium, pyrazolo[3′,4′:5,6]pyrimido[2,1‐b][1,3]‐thiazinium, and benzo[b]thieno[4′,3′:5,6]pyrimido[2,1‐b][1,3]thiazinium trihalogenides was developed via electrophilic heterocyclization of corresponding pyrimidine cinnamyl thioethers under the action of halogens. The XDR and complex NMR investigations were used for solving of final products structure; the anisochronism was observed in the NMR spectra of synthesized compounds for the pairs of ortho‐ and meta‐protons, as well as the N‐phenyl substituents associated with them.
“It's a burden, it's a nuisance. I wish I didn't have these other ailments”: a qualitative exploration of comorbidities management among older people living with HIV who use drugs in Vancouver, British Columbia
Authors: Chayama Koharu Loulou , Ng Cara , Small Will , Ivsins Andrew , McNeil Ryan 
Published: October 2021

AbstractIntroductionPeople living with HIV (PLHIV) who use illicit drugs (other than or in addition to cannabis) are living longer due to antiretroviral therapy (ART). Older PLHIV who use drugs have an increased risk for comorbidities, and managing multiple health conditions is a growing concern among this population. However, in‐depth understandings of the lived realities and complexities of living with HIV alongside comorbidities among older PLHIV who use drugs remain limited. We sought to explore how older PLHIV who use drugs manage their comorbid conditions in a setting with universal ART access.MethodsBetween January 2019 and March 2020, semi‐structured, in‐depth interviews were conducted in Vancouver, Canada with 42 older PLHIV who use drugs and were living with at least one comorbidity. All participants were currently on ART, and had initiated treatment at least 2 years prior to the interviews. Data were analysed using inductive and deductive approaches.ResultsSeveral themes were identified through this analysis. First, comorbidities were perceived as more urgent health concerns and prioritized over HIV. Second, stigma and discrimination hindered access to care for comorbidities. Third, the concurrent management of HIV and comorbidities was often challenging due to unmanaged or poorly managed comorbidities. Fourth, the potential impact of ART on the development of comorbidities was a source of concern and frustration. Finally, integrated treatment approaches facilitated engagement with HIV and comorbidities care.ConclusionsOur findings underscore the need for HIV care to shift from a primary focus on managing HIV to an integrated, patient‐centred approach that addresses both HIV and non‐HIV‐related health needs, as well as an equitable and non‐judgemental delivery of such care for an ageing population of PLHIV who use drugs.
Polymorphonuclear myeloid-derived suppressor cells link inflammation and damage response after trauma
Authors: Li Xinyao , Liu Jingping , Xing Zhe , Tang Jian , Sun Hengbiao , Zhang Xiaogang , Lv Shuaijun , Chen Ziyang , Shi Mengyu , Chen Meiqi , Zuo Shaowen , Lyu Xiaoming , He Yumei 
Published: October 2021

AbstractElimination of the posttraumatic inflammatory response and recovery of homeostasis are crucial for the positive prognosis of trauma patients. Myeloid-derived suppressor cells (MDSCs) are known to play a regulatory role in the posttraumatic immune response in mice, but their induction source and involved potential mechanism are poorly understood. Here, we report that polymorphonuclear MDSCs (PMN-MDSCs) are activated after trauma and are closely associated with the progression of the posttraumatic inflammatory response. In humans, lectin-type oxidized LDL receptor 1 (LOX1) was used to specifically characterize LOX1+ PMN-MDSCs. Trauma patients showed high intracellular reactive oxygen species (ROS) production, as well as activation of LOX1+ PMN-MDSCs. These MDSCs contribute to the anti-inflammatory immune response by regulating the Treg/Th17 and Th2/Th1 balances after trauma, increasing the levels of anti-inflammatory factors, and decreasing the levels of proinflammatory factors. The number of LOX1+ PMN-MDSCs was positively correlated with the positive clinical prognosis of trauma patients with infection. Activation of LOX1+ PMN-MDSCs is mediated by NF-κB signal, and TGF-β1 may be as an important inducer for LOX1+ PMN-MDSCs in the posttraumatic cytokine environment. In a pseudofracture trauma mouse model, we also observed the activation of PMN-MDSCs, accompanying high levels of intracellular ROS production, NF-κB phosphorylation, and changes in the inflammatory environment, in particularly by regulating the Treg/Th17 and Th2/Th1 balance. And more significantly, posttraumatic inflammation was alleviated in mice after transferring trauma-derived PMN-MDSCs, but aggravated after injecting with Gr1 agonistic antibody. These findings provide evidence for the specific role of PMN-MDSCs in the regulation of posttraumatic inflammation.
Nomogram to predict overall survival of patients with pseudomyxoma peritonei of appendiceal origin: A retrospective cohort study
Authors: Bai Mingjian , Wang Shilong , Ma Ruiqing , Cai Ying , Lu Yiyan , Hou Nianzong , Liang Guowei , Xu Hongbin , Zhang Man 
Published: October 2021

AbstractBackgroundPseudomyxoma peritonei (PMP) is a rare disease, with the rate of overall survival (OS) influenced by many factors. The present study aimed to define independent predictors and establish a nomogram for individual risk prediction in PMP patients.MethodsOne hundred forty‐seven PMP patients were consecutively included between June 1, 2013, and November 22, 2019. The log‐rank test was used to compare the OS rate between groups; subsequently, variables with p < .10 were subjected to multivariate Cox modeling for defining independent prediction indicators. Finally, a nomogram was established based on independent prognosticators and assessed for internal validation.ResultsMultivariate Cox analysis showed that D‐dimer level, carbohydrate antigen (CA) 125 level, CA 19‐9 level, degree of radical surgery, and histological grade were all independently associated with OS in PMP patients. A nomogram was plotted and underwent internal validation. The discrimination ability of the nomogram revealed a good predictive ability as indicated by the C‐index value (0.825), and calibration plots confirmed good consistency between the predicted and observed survival probabilities.ConclusionsFive independent prognostic factors for predicting the survival of PMP patients were identified, and the nomogram based on these independent indicators showed a reasonable discrimination ability for individual risk prediction.
Long‐term stability and storage of meta‐cresol purple solutions for seawaterpHmeasurements
Authors: Woosley Ryan J. 
Published: October 2021

AbstractChanges in seawater pH resulting from anthropogenic influence, termed ocean acidification, have significant implications. Monitoring and evaluating ocean acidification requires highly precise measurements comparable among many laboratories over decades. Short‐term repeatability can be achieved with spectrophotometric methods, but comparability among studies is much less certain. The indicator used plays an important role in measurement quality. Meta‐cresol purple (mCp), which is used for most seawater pH measurements, is known to break down under exposure to ultraviolet light, which can impact the long‐term stability of the indicator, and thus the quality of the measurements. Here, certified reference material and 2‐hydroxymethyl‐1,3‐propanediol (TRIS) buffers were used to assess the long‐term stability of mCp solutions. Purified indicator solutions were found to be stable (within 0.0025) at room temperature in a dark container for at least 5.3 years. Uncertainties in unpurified indicators made the stability assessment inconclusive. Such long‐term stability minimizes one potential source of uncertainty when comparing measurements and can reduce costs and waste by not prematurely disposing of indicator solutions that remain useable. Changes in the pH of the indicator solution indicate the indicator perturbation correction should be regularly determined. TheA434impcorrection method for determining impurities could be used as a quality assurance measure by making measurements over the life of the indicator solution to monitor for changes in the solution. However, the choice of molar absorptivities required for the calculation impacts the magnitude of the correction and thus warrants further study to improve best practices for making corrections to impure indicators.
Development of Antibacterial and Hemostatic PCL/Zein/ZnO‐Quaternary Ammonium Salts NPs Composite Mats as Wound Dressings
Authors: Wang Yang , Ying Maoli , Zhang Meng , Ren Xuehong , Kim Ick Soo 
Published: October 2021

AbstractWound dressings are usually employed to maintain suitable conditions around the injured skin to accelerate wound healing. This paper aims to report functional composite dressings combined with polycaprolactone (PCL) nanofibers, self‐assembly zein coating and modified ZnO nanoparticles (ZnO NPs) for wound management. The synthetic compounds and prepared composite dressings are characterized by Fourier infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and energy‐dispersive X‐ray spectroscopy. Meanwhile, the water vapor transmission rate, hemostatic performance, antibacterial activity, and cytocompatibility of the composite dressings are systematically tested to evaluate their applicability in wound treatment. The results show that the multilayer dressings can retain moisture and prevent excessive dehydration of wound. In vitro hemostatic test is conducted, and the enhanced blood clotting capacity and the activation of platelets indicate that the desired dressings are able to control hemorrhaging from wound. Meanwhile, the composite dressings with excellent biocidal efficacy against Gram‐positive Staphylococcus aureus (6.01 Log within 30 min) and Gram‐negative Escherichia coli O157:H7 (6.04 Log within 30 min) can effectively prevent wound infection. Furthermore, the dressings show no toxicity which are evidenced in hemolysis and cytocompatibility evaluation, and have potential application for wound healing.
Preparation of Poly(thiol‐urethane) Covalent Adaptable Networks Based on Multiple‐Types Dynamic Motifs
Authors: Xue Ying , Li Chunmei , Wang Wenyan , Liu Zongxu , Guo Zijian , Tan Jiaojun , Zhang Qiuyu 
Published: October 2021

AbstractTo solve the issue of polymeric materials recycling, developing intrinsic self‐healing materials containing dynamic bonds has attracted many researchers’ highly concerning. However, the tradeoff between their mechanical strength and stretchability always does not avoid. Herein, to surmount the above tradeoff, metal–ligand (Cu2+–S) interactions are introduced into the cross‐linking polythiourethane covalent adaptable networks (PTU CANs) with three kinds of dynamic motifs (thiourethane, disulfide, and hydrogen bonds). When the molar ratio of Cu2+ to S is 6.37%, the break strength (9.41 ± 0.34 MPa) and Young's modulus (26.02 ± 0.55 MPa) of the metal–ligand coordination complex PTU (Cu2+‐PTU‐3) dramatically increase, whereas the peak strain almost does not decline (454.44 ± 3.95%). To conduct the repairing, Cu2+‐PTU‐3 is further confirmed excellent repairing capability. Therefore, these new PTU CANs have significant potential for the new self‐healing materials.
Scaling Behavior and Structure–Property Relationships of Multifunctional Ternary‐Hydrogels Based on N‐Alkyl Methacrylate Esters: Property Tunability through Versatile Synthesis
Authors: Bozbay Rabia , Orakdogen Nermin 
Published: October 2021

AbstractScaling behavior relating the synthesis conditions with swelling degree, preparation concentration and crosslinking density of multifunctional ternary‐gels consisting of 2‐(dimethylamino)ethyl methacrylate (DMAEMA), hydroxypropyl methacrylate (HPMA) and glycidyl methacrylate (GMA) is reported. Swelling is controlled by DMAEMA portion of terpolymers and DMAEMA‐rich gels tended to swell more than GMA‐rich gels and increase in GMA increase polymer‐solvent interaction parameter,χCritical conditions required for terpolymers to show phase transition are calculated asχ1=0.4993 andχ2=0.2959. Dependence of swelling degreeϕVon gel preparation concentration as a function of solvent quality is examined. Good solvent prediction of indicates a crossover between entanglement‐dominated case and strongly cross‐linked case corresponding to low and moderate degrees of swelling. Swelling of ternary‐gels in different solvents shows that cyclohexanol is a good solvent and solubility parameter is 23.7 (MPa)1/2. Addition of hydrophobic GMA leads to a significant increase in stiffness of terpolymer gels. Increase in elastic modulus as‐prepared state is not monotonic and can be controlled by adjusting DMAEMA/GMA ratio since tertiary amine groups triggers cascading epoxy ring‐opening reaction. Reduced modulusGrdecreased with increasing swelling degree and scaling relation between modulus and swelling is found asGr≈ (ϕV)−0.66which indicates that ternary‐hydrogels, limited to weak stretching regime, obey Gaussian statistics.
Numerical strategies for variational updates in large strain inelasticity with incompressibility constraint
Authors: Sielenkämper Marian , Dittmann Jan , Wulfinghoff Stephan 
Published: October 2021

AbstractIn finite deformation inelasticity, one often has to deal with the incompressibility constraint. In the past, this was dealt with using, for example, an exponential mapping approach, which yields exact volume preservation in plastic deformations. In this article however, the special‐linear update approach by Hurtado et al. The special‐linear update: An application of differential manifold theory to the update of isochoric plasticity flow rules, Int J Numer Methods Eng. 2014;97(4):298‐312, which utilizes a projection method to fulfill the incompressibility constraint is used. The model is applied to isotropic plasticity by a novel approximation of the logarithm and treats kinematic hardening without losing the symmetry of the internal variables. The model results are compared to models utilizing an exponential mapping approach in numerical experiments.
Is gamma knife radiosurgery for skull base meningiomas with carotid artery encasement supported by efficacy and safety outcomes?
Authors: Ampil Federico L. , Sin Anthony H. , Smith Donald R. 
Published: October 2021

AbstractClinical outcomes were reviewed in 30 patients treated by gamma knife radiosurgery for skull base meningiomas with carotid artery encasement (SKBM‐CAE). The overall clinical improvement rate after treatment was 46%. At a median imaging follow‐up of 49 months, tumor volumes were unchanged, were larger, and were smaller or had resolved in 70%, 23%, and 7% of cases, respectively. The crude survival rate at 10 years was 20% and the complication (new cranial nerve deficit not accompanied by imaging‐shown tumor growth) rate was 10%. SKBM‐CAE is amenable to being effectively and safely controlled with the application of gamma knife radiosurgery.