bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognosis and risk factors of ERCP pancreatitis in elderly
Authors: Ergin Erhan , Oruç Nevin , Ersöz Galip , Tekeşin Oktay , Özütemiz Ömer 
Published: August 2021

AbstractPost Endoscopic Retrograde Cholangiopancreatography (ERCP) pancreatitis is one of the most serious complications of ERCP. Our study aims to investigate the risk, predisposing factors and prognosis of pancreatitis after ERCP in elderly patients. Patients referred to the ERCP unit between April 2008 and 2012 and admitted to the hospital at least 1 day after the ERCP procedure were included to the study. Information including patient’s demographics, diagnosis, imaging findings, biochemical analysis, details of the ERCP procedure and complications were recorded. The severity of post ERCP pancreatitis (PEP) was determined by revised Atlanta Criteria as well as APACHE II and Ranson scores. A total of 2902 ERCP patients were evaluated and 988 were included to the study. Patients were divided into two groups as ≥ 65 years old (494 patients, 259 F, 235 M) and < 65 years old (494 patients, 274 F, 220 M). PEP was diagnosed in 4.3% of patients aged 65 years and older. The female gender was risk factors in elderly for PEP. The Sphincter Oddi Dysfunction (SOD) and Juxta papillary diverticula (JPD) were higher in elderly patients with PEP. Age did not increase the risk of PEP development. The most important post ERCP pancreatitis risk factor in the elderly is the female gender, while the risk is enhanced slightly by SOD and JPD.
Sleep maturation influences cognitive development of preterm toddlers
Authors: Ando Akiko , Ohta Hidenobu , Yoshimura Yuko , Nakagawa Machiko , Asaka Yoko , Nakazawa Takayo , Mitani Yusuke , Oishi Yoshihisa , Mizushima Masato , Adachi Hiroyuki , Kaneshi Yosuke , Morioka Keita , Shimabukuro Rinshu , Hirata Michio , Ikeda Takashi , Fukutomi Rika , Kobayashi Kyoko , Ozawa Miwa , Takeshima Masahiro , Manabe Atsushi , Takahashi Tsutomu , Mishima Kazuo , Kusakawa Isao , Yoda Hitoshi , Kikuchi Mitsuru , Cho Kazutoshi 
Published: August 2021

AbstractOur recent study on full-term toddlers demonstrated that daytime nap properties affect the distribution ratio between nap and nighttime sleep duration in total sleep time but does not affect the overall total amount of daily sleep time. However, there is still no clear scientific consensus as to whether the ratio between naps and nighttime sleep or just daily total sleep duration itself is more important for healthy child development. In the current study, to gain an answer to this question, we examined the relationship between the sleep properties and the cognitive development of toddlers born prematurely using actigraphy and the Kyoto scale of psychological development (KSPD) test. 101 premature toddlers of approximately 1.5 years of age were recruited for the study. Actigraphy units were attached to their waist with an adjustable elastic belt for 7 consecutive days and a child sleep diary was completed by their parents. In the study, we found no significant correlation between either nap or nighttime sleep duration and cognitive development of the preterm toddlers. In contrast, we found that stable daily wake time was significantly associated with better cognitive development, suggesting that sleep regulation may contribute to the brain maturation of preterm toddlers.
Role of structural specificity of ZnO particles in preserving functionality of proteins in their corona
Authors: Singh Urvashi , Saifi Zeeshan , Kumar Mridul , Reimers Armin , Krishnananda Soami Daya , Adelung Rainer , Baum Martina 
Published: August 2021

AbstractReconfiguration of protein conformation in a micro and nano particle (MNP) protein corona due to interaction is an often-overlooked aspect in drug design and nano-medicine. Mostly, MNP-Protein corona studies focus on the toxicity of nano particles (NPs) in a biological environment to analyze biocompatibility. However, preserving functional specificity of proteins in an NP corona becomes critical for effective translation of nano-medicine. This paper investigates the non-classical interaction between insulin and ZnO MNPs using a classical electrical characterization technique at GHz frequency with an objective to understand the effect of the micro particle (MP) and nanoparticle (NP) morphology on the electrical characteristics of the MNP-Protein corona and therefore the conformation and functional specificity of protein. The MNP-Protein corona was subjected to thermal and enzymatic (papain) perturbation to study the denaturation of the protein. Experimental results demonstrate that the morphology of ZnO particles plays an important role in preserving the electrical characteristics of insulin.
Dual solution framework for mixed convection flow of Maxwell nanofluid instigated by exponentially shrinking surface with thermal radiation
Authors: Shi Qiu-Hong , Ahmed Bilal , Ahmad Sohail , Khan Sami Ullah , Sultan Kiran , Bashir M. Nauman , Khan M. Ijaz , Shah Nehad Ali , Chung Jae Dong 
Published: August 2021

AbstractThis paper presents the analysis of transfer of heat and mass characteristics in boundary layer flow of incompressible magnetohydrodynamic Maxwell nanofluid with thermal radiation effects confined by exponentially shrinking geometry. The effects of Brownian motion and thermophoresis are incorporated using Buongiorno model. The partial differential equations of the governing model are converted in non-dimensional track which are numerically inspected with proper appliances of Runge–Kutta fourth order scheme.The significant effects of heat and mass fluxes on the temperature and nanoparticles volume fractions are investigated. By the increases in Lewis number between $$1.0$$

1.0

to $$2.0$$

2.0

, the decrease in nanoparticle volume fraction and temperature is noted. With the change in the Prandtl constant that varies between $$0.7$$

0.7

to $$1.5$$

1.5

, the nanoparticles volume fraction and temperature are dwindled. Nanoparticles volume fraction and temperature distribution increase is noted with applications of radiation constant. With consequent variation of thermophoresis parameter between $$0.1$$

0.1

to $$0.8$$

0.8

, nanoparticles volume fraction and temperature distribution increases. It is also noted that the increase in thermophoresis parameter and Brownian parameter from $$0.1$$

0.1

to $$0.8$$

0.8

, nanoparticles volume fraction decreases while temperature distribution increases.
Favorable pleiotropic loci for fiber yield and quality in upland cotton (Gossypium hirsutum)
Authors: Wang Pengpeng , He Shoupu , Sun Gaofei , Pan Zhaoe , Sun Junling , Geng Xiaoli , Peng Zhen , Gong Wenfang , Wang Liru , Pang Baoyin , Jia Yinhua , Du Xiongming 
Published: August 2021

AbstractUpland cotton (Gossypium hirsutum L.) is an important economic crop for renewable textile fibers. However, the simultaneous improvement of yield and fiber quality in cotton is difficult as the linkage drag. Compared with breaking the linkage drag, identification of the favorable pleiotropic loci on the genome level by genome-wide association study (GWAS) provides a new way to improve the yield and fiber quality simultaneously. In our study restriction-site-associated DNA sequencing (RAD-seq) was used to genotype 316 cotton accessions. Eight major traits in three categories including yield, fiber quality and maturation were investigated in nine environments (3 sites × 3 years). 231 SNPs associated with these eight traits (− log10(P) > 5.27) were identified, located in 27 genomic regions respectively by linkage disequilibrium analysis. Further analysis showed that four genomic regions (the region 1, 6, 8 and 23) held favorable pleiotropic loci and 6 candidate genes were identified. Through genotyping, 14 elite accessions carrying the favorable loci on four pleiotropic regions were identified. These favorable pleiotropic loci and elite genotypes identified in this study will be utilized to improve the yield and fiber quality simultaneously in future cotton breeding.
MELD-accelerated molecular dynamics help determine amyloid fibril structures
Authors: Sharma Bhanita , Dill Ken A. 
Published: August 2021

AbstractIt is challenging to determine the structures of protein fibrils such as amyloids. In principle, Molecular Dynamics (MD) modeling can aid experiments, but normal MD has been impractical for these large multi-molecules. Here, we show that MELD accelerated MD (MELD x MD) can give amyloid structures from limited data. Five long-chain fibril structures are accurately predicted from NMR and Solid State NMR (SSNMR) data. Ten short-chain fibril structures are accurately predicted from more limited restraints information derived from the knowledge of strand directions. Although the present study only tests against structure predictions – which are the most detailed form of validation currently available – the main promise of this physical approach is ultimately in going beyond structures to also give mechanical properties, conformational ensembles, and relative stabilities.
Quantitative ubiquitylomics reveals the ubiquitination regulation landscape in oral adenoid cystic carcinoma
Authors: Li Wen , Wang Xiaobin , Zhang Qian , Wang Hanlin , Zuo Wenxin , Xie Hongliang , Tang Jianming , Wang Mengmeng , Zeng Zhipeng , Cai Wanxia , Tang Donge , Dai Yong 
Published: August 2021

Abstract
Adenoid cystic carcinoma (ACC) is an extremely rare salivary gland tumor with a poor prognosis and needs attention on molecular mechanisms. Protein ubiquitination is an evolutionarily conserved post-translational modification (PTM) for substrates degradation and controls diverse cellular functions. The broad cellular function of ubiquitination network holds great promise to detect potential targets and identify respective receptors. Novel technologies are discovered for in-depth research and characterization of the precise and dynamic regulation of ubiquitylomics in multiple cellular processes during cancer initiation, progression and treatment. In the present study, 4D label-free quantitative techniques of ubiquitination proteomics were used and we identified a total of 4152 ubiquitination sites in 1993 proteins. We also performed a systematic bioinformatics analysis for differential modified proteins and peptides containing quantitative information through the comparation between oral ACC (OACC) tumor with adjacent normal tissues, as well as the identification of eight protein clusters with motif analysis. Our findings offered an important reference of potential biomarkers and effective therapeutic targets for ACC.
Nonstandardized Assessment of Cognitive-Communication Abilities Following Pediatric Traumatic Brain Injury: A Scoping Review
Authors: Hall Audrey , Lundine Jennifer P. , McCauley Rebecca J. 
Published: August 2021

Purpose
The purpose of this study is to describe and synthesize existing research on nonstandardized assessment of cognitive-communication abilities in children with traumatic brain injury (TBI) in order to improve the detection, diagnosis, and tracking of injury sequelae and guide appropriate service provision.

Materials and Method
A search of peer-reviewed journal databases revealed 504 unique articles published between January 2000 and August 2019. For full inclusion, articles had to report on empirical studies examining variables related to the nonstandardized assessment of cognitive-communication skills following TBI in children. Review articles, expert opinion pieces, and non–English language articles were excluded. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guided this process.

Results

Results were tabulated for each of the 14 articles that met full inclusion criteria. Included studies presented five different types of nonstandardized assessment: discourse analysis (
n
= 3), systematic observation of child's performance during an instrumental activity of daily living (
n
= 4), virtual reality tasks (
n
= 3), structured cognitive tasks (
n
= 2), and functional rating scales (
n
= 2). The majority of included studies compared the outcomes of nonstandardized assessment against subtest scores and checklists drawn from a variety of existing standardized and criterion-referenced assessments. Targeted cognitive-communication skills included attention, working memory, self-regulation, planning, multitasking, social problem-solving, inferencing, and macrolevel discourse.

Conclusions
Preliminary research suggests that a well-designed and systematically implemented nonstandardized assessment can yield essential information about children's cognitive-communication abilities in real-world contexts. Further research is needed to validate these assessments and to determine in which settings and situations they may prove most effective.

Supplemental Material

https://doi.org/10.23641/asha.15079026
INSPIRE: INvestigating Stellar Population In RElics
Authors: Spiniello C. , Tortora C. , D’Ago G. , Coccato L. , La Barbera F. , Ferré-Mateu A. , Pulsoni C. , Arnaboldi M. , Gallazzi A. , Hunt L. , Napolitano N. R. , Radovich M. , Scognamiglio D. , Spavone M. , Zibetti S. 
Published: August 2021

Context. The INvestigating Stellar Population In RElics (INSPIRE) is an ongoing project targeting 52 ultra-compact massive galaxies at 0.1 <  z <  0.5 with the X-shooter at VLT spectrograph (XSH). These objects are the ideal candidates to be ‘relics’, massive red nuggets that have formed at high redshift (z >  2) through a short and intense star formation burst, and then have evolved passively and undisturbed until the present day. Relics provide a unique opportunity to study the mechanisms of star formation at high-z.
Aims.INSPIRE is designed to spectroscopically confirm and fully characterise a large sample of relics, computing their number density in the redshift window 0.1 <  z <  0.5 for the first time, thus providing a benchmark for cosmological galaxy formation simulations. In this paper, we present the INSPIRE Data Release (DR1), comprising 19 systems with observations completed in 2020.
Methods. We use the methods already presented in the INSPIRE Pilot, but revisiting the 1D spectral extraction. For the 19 systems studied here, we obtain an estimate of the stellar velocity dispersion, fitting the two XSH arms (UVB and VIS) separately at their original spectral resolution to two spectra extracted in different ways. We estimate [Mg/Fe] abundances via line-index strength and mass-weighted integrated stellar ages and metallicities with full spectral fitting on the combined (UVB+VIS) spectrum.
Results. For each system, different estimates of the velocity dispersion always agree within the errors. Spectroscopic ages are very old for 13/19 galaxies, in agreement with the photometric ones, and metallicities are almost always (18/19) super-solar, confirming the mass–metallicity relation. The [Mg/Fe] ratio is also larger than solar for the great majority of the galaxies, as expected. We find that ten objects formed more than 75% of their stellar mass (M⋆) within 3 Gyr from the big bang and classify them as relics. Among these, we identify four galaxies that had already fully assembled their M⋆ by that time and are therefore ‘extreme relics’ of the ancient Universe. Interestingly, relics, overall, have a larger [Mg/Fe] and a more metal-rich stellar population. They also have larger integrated velocity dispersion values compared to non-relics (both ultra-compact and normal-size) of similar stellar mass.
Conclusions. The INSPIRE DR1 catalogue of ten known relics is the largest publicly available collection, augmenting the total number of confirmed relics by a factor of 3.3, and also enlarging the redshift window. The resulting lower limit for the number density of relics at 0.17 <  z <  0.39 is ρ ∼ 9.1 × 10−8 Mpc−3.
Mg2SiO4 particle aggregation aboard the ISS
Authors: Koch T. E. , Spahr D. , Merges D. , Winkler B. , Brenker F. E. 
Published: August 2021

Context. Particle aggregation in the solar nebula played a major role in the framework of planet formation; for example, primitive meteorites and their components formed by different aggregation processes. These processes are still not completely understood.
Aims. Electrostatic forces probably influenced particle aggregation in the early Solar System. We developed an experiment that was carried out under long-term microgravity conditions aboard the International Space Station (ISS) to expand the knowledge of charge-influenced particle aggregation.
Methods. Aggregation of freely floating, elongated, angular, and polycrystalline Mg2SiO4-particles was observed under long-term microgravity conditions while being exposed to electric fields as well as low- and high-energy electric discharges.
Results. Nearly all of the particles formed an aggregate, which freely floated in the sample chamber prior to the discharge experiments. The aggregate was attracted by the electrodes and partly disintegrated by low-energy electric discharges. High-energy arc discharges accelerated the particles, which reassembled in chains parallel to the field lines of the subsequent electric field between the electrodes. A strong shape-preferred orientation of the longest grain axis parallel to the field lines was observed in the Mg2SiO4-particles. With increasing strength of the electric field, the particle chains narrowed, leading to the formation of a compact aggregate.
Conclusions. In microgravity conditions, electrostatic forces influence the aggregation process in terms of aggregate growth rate, morphology, packing density, and particle orientation. These observations help us to better understand the formation and compaction mechanism of early Solar System aggregates.
Arzneisymptome unter homöopathischer Behandlung
Authors: Reis Stefan 
Published: August 2021

ZusammenfassungVorliegende Arbeit befasst sich mit der Erweiterung der homöopathischen Materia medica durch Verlaufsbeobachtungen in der Praxis. Anhand von 2 Praxisbeispielen wird diskutiert, unter welchen Voraussetzungen neu auftretende Symptome als pathogenetisch zu identifizieren sind.
Diagnostic Accuracy of Dual-Layer Spectral CT Using Electron Density Images to Detect Post-Traumatic Prevertebral Hematoma of the Cervical Spine
Authors: Sedaghat Sam , Langguth Patrick , Larsen Naomi , Campbell Graeme , Both Marcus , Jansen Olav 
Published: August 2021

Purpose To investigate the diagnostic value of dual-layer spectral detector computed tomography (SDCT) in detecting posttraumatic prevertebral hematoma of the cervical spine by including electron density images.
Methods 38 patients with post-traumatic imaging of the cervical spine were included in this study and received both SDCT and MRI examinations. MRI was set as the reference and combined conventional/electron density (C + ED) images were compared to conventional CT (CCT) images alone.
Results A total of 18 prevertebral hematomas were identified. Reader 1 identified 14 of 18 and reader 2 15 of 18 prevertebral hematomas by using C + ED reconstructions. Readers 1 and 2 detected 6 and 9 of 18 hematomas on CCT, respectively. CCT showed a sensitivity of 33–50 % and a specificity of 75–80 %, while for C + ED reconstructed images the sensitivity was 77–83 % and the specificity was 85–90 %. Accuracy increased from 55–66 % to 84 % by using C + ED images. The minimum thickness for detecting hematoma on C + ED images was 3 mm. The sizes of prevertebral hematoma on CCT/C + ED were not significantly under- or overestimated compared to the MRI reference. There was a significant difference between the two readers for measuring hematoma sizes on CCT (p = 0.04). Readers showed an excellent inter-rater reliability (kappa = 0.82) for C + ED images and a moderative inter-rater reliability (kappa = 0.44) for CCT.
Conclusion With SDCT, the diagnostic accuracy for detecting post-traumatic prevertebral hematoma is improved by using combined conventional and electron density reconstructions compared to conventional images alone.
Key Points:
Citation Format
Geschlechtsspezifische Unterschiede aggressiven Verhaltens und der Anwendung von Zwangsmaßnahmen bei stationär psychiatrischen Patienten und Patientinnen
Authors: Ketelsen Regina , Fernando Silvia , Driessen Martin 
Published: August 2021

Zusammenfassung
Ziel der Studie In einer klinischen Gesamtpopulation aller vollstationären Behandlungsfälle werden geschlechtsspezifische Unterschiede über 15 Jahre bei fremdaggressivem Verhalten und Zwangsmaßnahmen (ZM) überprüft.
Methodik Aggressive Ereignisse werden mit der Staff Observation Aggression Scale-Revised (SOAS-R) und ZM mit einem hierzu entwickelten Erfassungsbogen von 2005–2019 standardisiert erfasst und retrospektiv hinsichtlich geschlechtsspezifischer Unterschiede ausgewertet.
Ergebnisse 82 833 vollstationäre Behandlungsfälle (Männer: 55,3 %; Frauen: 44,7 %) gingen in die Untersuchung ein. Während des Erhebungszeitraums wurden 60,1 % der erfassten Ereignisse durch Patienten und 39,9 % durch Patientinnen verübt, allerdings war auf Fallebene das Risiko für das Auftreten aggressiven Verhaltens für Männer und Frauen vergleichbar (Odds Ratio: 1,1). Im SOAS-R wiesen Frauen signifikant schwerwiegendere aggressive Handlungen auf, nach subjektiver Einschätzung durch Mitarbeitende werden aber aggressive Vorfälle von Männern schwerer eingestuft. Diese erhielten zudem signifikant mehr und länger andauernde ZM als Frauen.
Schlussfolgerung Das subjektive Erleben aggressiven Verhaltens durch Mitarbeitende könnte dazu beitragen, dass ZM bei Patienten signifikant häufiger und länger eingesetzt werden.
Five-Membered-Ring-Fused Tacrines as Anti-Alzheimer’s Disease Agents
Authors: Carreiras Maria do Carmo , Marco-Contelles José 
Published: August 2021

AbstractOur endeavors in the design, synthesis, and biological assessment of five-membered-ring-fused tacrines as potential therapeutic agents for Alzheimer’s disease are summarized. Particularly, we have identified racemic 4-(2-methoxyphenyl)-3-methyl-2,4,6,7,8,9-hexahydropyrazolo[4′,3′:5,6]pyrano[2,3-b]quinolin-5-amine, a pyranopyrazolotacrine, as having the best nontoxic profile at the highest concentrations used (300 μM); this allows cell viability, is less hepatotoxic than tacrine, and is a potent noncompetitive AChE inhibitor (IC50 = 1.52 ± 0.49 μM). It is able to completely inhibit the EeAChE-induced Aβ1–40 aggregation in a statistically significant manner without affecting the Aβ1–40 self-aggregation at 25 μM, and shows strong neuroprotective effects (EC50 = 0.82 ± 0.17 μM).1	Introduction2	Furo-, Thieno-, and Pyrrolotacrines3	Pyrazolo-, Oxazolo-, and Isoxazolotacrines4	Indolotacrines5	Pyrano- and Pyridopyrazolotacrines6	Conclusions and Outlook
Magnetic Resonance Imaging in Giant Perianal Epidermoid
Authors: Patil Aruna Raman , Bansal Amit , Chakma Nilotpal , Bhat Ravishankar , Shivakumar Swarna 
Published: August 2021

AbstractPerianal epidermoid cyst is a rare entity and is commonly diagnosed late owing to its slow-growing nature. Imaging plays a vital role in diagnosis and differentiation from other cysts such as dermoid, tailgut, and rectal duplication cysts. Magnetic resonance imaging (MRI) is the preferred modality as uncomplicated cases show typical signal changes. Diffusion-weighted imaging has a definite additional role. We report a case of a giant perianal epidermoid diagnosed on MRI and successfully managed surgically.