bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations: a mega-analysis
Authors: Vignando Miriam , ffytche Dominic , Lewis Simon , Lee Phil Hyu , Chung Seok , Weil Rimona , Hu Michele , Mackay Clare , Griffanti Ludovica , Pins Delphine , Dujardin Kathy , Renaud Jardri , Taylor John-Paul , Firbank Michael , Mcalonan Grainne , Mak Henry Ka-Fung , Ho Shu-Leong , Mehta Mitul 
Published: March 2021

Abstract
Parkinson’s psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson’s disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to pool together structural imaging data from multiple research groups into a large-scale mega-analysis, allowing us to apply new methodological approaches to identify cortical regions and networks involved in VH and their relation to receptor binding. Differences of cortical thickness and surface area show a wider cortical involvement underlying VH than previously recognised, including primary visual cortex and its surrounds, and the hippocampus, independent of its role in cognitive decline. Structural covariance analyses point to a strong involvement of the attentional control networks in PD-VH, while associations with receptor density maps suggest neurotransmitter loss may drive the cortical changes.
IRF4 deficiency vulnerates B progeny for leukemogenesis via Jak3 mutations resembling Ph-like B-ALL in humans
Authors: Gupta Dennis Das , Paul Christoph , Bollig Nadine , Bieringer Maria , Staudenraus Daniel , Raifer Hartmann , Menke Lisa , Camara Bärbel , Roth Edith , Daum Patrick , Wanzel Michael , Mernberger Marco , Nist Andrea , Bauer Uta-Maria , Marini Federico , Helmprobst Frederik , Buchholz Malte , Jäck Hans-Martin , Neubauer Andreas , Burchert Andreas , Klein Matthias , Bopp Tobias , Stiewe Thorsten , Pagenstecher Axel , Lohoff Michael 
Published: March 2021

Abstract
How disturbances of B cell development provoke adult B acute lymphoblastic leukemia (B-ALL) remains poorly understood. Here we describe Irf4–/– mice as prone to developing B-ALL with age. Irf4–/– pro/preB cells exhibited impaired differentiative but enhanced proliferative potential in vitro and accumulated in spleens of healthy Irf4–/– mice, suggesting reduced adherence to the IL-7 providing bone marrow niche. Thus selected, pro/preB cells transformed acquiring proliferative IL-7 independency through Jak3 gain-of-function mutations. Targeting JAK signaling with Ruxolitinib in vivo prolonged survival of mice bearing established Irf4–/– leukemia. Intriguingly, organ infiltration including leukemic meningeosis was selectively reduced without affecting blood blast counts. As low IRF4 expression and JAK3 mutations also characterize a subpopulation of Ph-like B-ALL in adult humans, our results imply Irf4–/– mice as a suitable model for investigating preleukemic conditions in adults. Using this model, we identified an unexpected effect of Ruxolitinib treatment in B-ALL.
Management of Primary Mediastinal Yolk Sac Tumors: A Single Institution Experience with 10 Patients
Authors: Yu Yang , Jiang Yong , Zhang Xuanwei , Na Feifei , Xiu Weigang , Li Yanying , Huang Meijuan , Lu You , Gong Youling 
Published: March 2021

Abstract
Background: Primary mediastinal yolk sac tumors is a kind of primary mediastinal non-seminomatous germ cell tumor . The current treatment strategies in primary mediastinal non-seminomatous germ cell tumor is neoadjuvant chemotherapy followed by residual mass surgical resection . We reviewed our institutional 5 years' experience with Primary mediastinal yolk sac tumors who treated with platinum-based neoadjuvant chemotherapy and extended resection.Methods： We experienced 10 cases of Primary mediastinal yolk sac tumors from October of 2014 to October of 2019. 7 patients received preoperative platinum-based chemotherapy followed by surgical resection of residual mediastinal mass. The other 3 patients were received initial surgical resection without preoperative chemotherapy.Results：R0 resection was achieved in 8 patients (80%), and R2 resection was in the other 2 patients (20%). All the 7 patients with neoadjuvant chemotherapy were R0 resections, however all of them had viable tumor in their surgical specimen. Morbidities after surgery occurred in 2 patients, including 2 pneumonias ,1 type I respiratory failure and 1 acute left heart failure, and They were died within 2 months after surgery. At the time of writing ,3 patients are alive without evidence of disease,7 patients died , of which 5 patients have died of tumor-related causes and 2 died of postoperative complications. 8 patients were included in the follow-up. Among them 7patients experienced progressed within one year. 8 patients were included in the follow-up,mPFS and mOS in 8 patients were 3.7 months (2.6-41.3m) and 23.15 months (8.6-41.3m) , respectively. The 7 patients with neoadjuvant chemotherapy followed by surgical resection of residual diseases, 2-year survival rate was 57.1%,The 3-year survival rate was 28.6%Conclusion: An aggressive, multidisciplinary treatment including neoadjuvant chemotherapy followed by residual mass surgical resection is the optimal treatment and can be associated with prolonged survival.
Deep Reinforcement Learning and Performance Evaluation of Multi-layer Clustering Network with Enhanced Threshold Protocol
Authors: Bhola Jyothi , Shabaz Mohammad , DHIMAN GAURAV , Vimal S. , Subbulakshmi P. , Soni Sunil 
Published: March 2021

Abstract
In this research, pure deterministic system has been established by a new Distributed Energy Efficient Clustering Protocol with Enhanced Threshold (DEECET) by clustering sensor nodes to originate the Wireless Sensor Network. The DEECET is very dynamic, highly distributive, self-confessed and much energy efficient as compared to most of the other existing protocols. The MATLAB simulation provides aim proved result by means of energy dissipation being emulated in the networks lifespan for homogeneous as well as heterogeneous sensor network, which when contrasted for other traditional protocols. An enhanced result has been obtained for equitable energy dissipation for systematized networks using DEECET.
Functional and anatomical characterization of corticotropin-releasing factor receptor subtypes of the rat spinal cord involved in somatic pain relief
Authors: Mousa Shaaban , Shaqura Mohammed , Khalefa Baled , Li Li , Al-madol Mohammed , Treskatsch Sascha , Schäfer Michael 
Published: March 2021

Abstract
Corticotropin-releasing factor (CRF) orchestrates our body’s response to stressful stimuli. Pain is often stressful and counterbalanced by activation of CRF receptors along the nociceptive pathway, although the involvement of the CRF receptors of subtypes 1 and/or 2 (CRF-R1 and CRF-R2, respectively) in CRF-induced analgesia remains controversial. This study aimed to examine CRF-R1 and CRF-R2 expression within spinal cord of rats with Freund’s complete adjuvant-induced hindpaw inflammation using reverse transcriptase polymerase chain reaction, Western blot, radioligand binding, and immunofluorescence confocal analysis, Western blot, immunohistochemistry, and radioligand binding. Moreover, paw pressure algesiometry examined antinociceptive effects of intrathecal (i.t.) CRF and their possible antagonism through CRF-R1 and/or CRF-R2 selective antagonists as well as opioid receptor antagonist naloxone. Our results demonstrated mainly CRF-R2 mRNA, protein, binding sites and immunoreactivity in dorsal horn of rat spinal cord. In parallel, i.t. CRF as well as CRF-R2 agonists elicited potent antinociceptive effects which are dose-dependent and antagonized exclusively by i.t. CRF-R2 (K41498), but not CRF-R1 (NBI35965) antagonist. Moreover, i.t. CRF elicited inhibition of somatic pain that was dose-dependently reversed by the opioid antagonist naloxone. Consistently, double immunofluorescence confocal microscopy showed CRF-R2 on enkephalin (ENK) containing inhibitory interneurons in close opposition of incoming, mu-opioid receptor-immunoreactive nociceptive neurons but not on pre- nor on postsynaptic sensory neurons of the spinal cord. Taken together, these findings suggest that i.t. CRF or CRF-R2 agonist inhibits inflammatory somatic pain which occurs most predominantly through CRF-R2 receptors located on spinal enkephalinergic inhibitory interneurons resulting in endogenous opioid-mediated pain inhibition.
Application of Alginate Extraction Residue for Al(Iii) Ions Biosorption: A Complete Batch System Evaluation
Authors: Costa Heloisa Pereira de Sá , Silva Meuris Gurgel Carlos da , Vieira Melissa Gurgel Adeodato 
Published: March 2021

Abstract
The residue derived from the alginate extraction from S. filipendula was applied for the biosorption of aluminum from aqueous medium. The adsorptive capacity of the residue (RES) was completely evaluated in batch mode. The effect of pH, contact time, initial concentration and temperature was assessed through kinetic, equilibrium and thermodynamic studies. The biosorbent was characterized prior and post-Al biosorption by N2 physisorption, Hg porosimetry, He picnometry and thermogravimetry analyses. Equilibrium was achieved in 60 minutes. Kinetics obeys pseudo-second order model at aluminum higher concentrations. Isotherms followed Freundlich model at low temperature (293.15 K) and D-R or Langmuir model at higher temperatures (303 and 313 K). Data modeling indicated the occurrence of both chemical and physical interactions in the aluminum adsorption mechanism using RES. The maximum adsorption capacity obtained was of 1.431 mmol/g at 293 K. The biosorption showed a spontaneous, favorable and exotherm character. A simplified batch design was performed, indicating that the residue is a viable biosorbent, achieving high percentages of removal using low biomass dosage.
Seroprevalence of Human Coronaviruses Among Patients Visiting Hospital-Based Sentinel Sites in Uganda
Authors: ELIJAH MULABBI NICHOLAS , Tweyongyere Robert , Wabwire-Mangen Fred , Mworozi Edison , Koehlerb Jeff , Kibuuka Hannah , Millard Monica , Erima Bernard , Tugume Titus , Aquino Ukuli Qouilazoni , Byarugaba Denis K. 
Published: March 2021

Abstract
Background: Human coronaviruses are causative agents of respiratory infections with several subtypes being prevalent worldwide. They cause respiratory illnesses of varying severity and have been described to be continuously emerging but their prevalence is not well documented in Uganda. This study assessed the seroprevalence of antibodies against the previously known human coronaviruses prior 2019 in Uganda.Methods: A total 377 serum samples collected from volunteers that showed influenza like illness in five hospital-based sentinel sites and archived were analyzed using a commercial Qualitative Human Coronavirus Antibody IgG ELISA kit. Although there is no single kit available that can detect the presence of all the circulating coronaviruses, this kit uses a nucleoprotein, aa 340-390 to coat the wells and since there is significant homology among the various human coronavirus strains with regards to the coded for proteins, there is significant cross reactivity beyond HCoV HKU-39849 2003. This gives the kit a qualitative ability to detect the presence of human coronavirus antibodies in a sample. Results: The overall seroprevalence for all the sites was 87.53% with no significant difference in the seroprevalence between the Hospital based sentinel sites (p=0.8). Of the seropositive, the age group 1-5 years had the highest percentage (46.97), followed by 6-10 years (16.67) and then above 20 (16.36). The volunteers were divided into two broad categories, those below five years and those above five years, to calculate the odds ratio. The odds ratio of those seropositive with an age above 5 years with reference to those below 5 years was 0.62. This shows that those below 5 are more likely to be seropositive compared to those above 5 years. The seropositivity was generally high throughout the year with highest being recorded in March and the lowest in February and December. Conclusions: The seroprevalence of Human coronaviruses is alarmingly high which calls for need to identify and characterize the circulating coronavirus strains so as to guide policy on the control strategies.
Neutral Approach at Dividend Policy Modeling
Authors: Krylov Sergey 
Published: March 2021

Abstract
The article treats a concept of the formalized modeling of the dividend policy scores and company marketing performance scores derived (stock market position) within neutral dividend policy implementation approach conditions as an instrument of the scores analysis and forecasting. The methodology of the research consists of the Dividend Irrelevance theory, Dividend Policy Significance theory and sustainable company development concept. It has been stated that a formalized approach of the dividend policy implementation presumes a construction of the basic relevent scores models characterizing the company dividend policy and its marketing performance as Dividend Payout, Dividend Cover, expected Share Price, Dividend Yield, Price / Earnings Ratio (common stock price/earnings ratio). The formalized models of the scores mentioned are applicable for a forecast-analytical scores evaluation and their variances as well by estimating an impact of the models defining factors exercised by the appropriate factoring analysis method within the neutral dividend policy implementation approach conditions. The conclusion is drawn, that the formalized models of the dividend policy scores and company marketing performance scores derived, having been developed, are an effective instrument for their forecasting and analysis so that proactive decisions to manage the company dividend policy implementation within neutral approach conditions are ensured.
Assessment of the Perceived Just Culture Among Nurses: A Cross- Sectional Study
Authors: LOGRONO KENNETH JUN 
Published: March 2021

Abstract
Background
Achieving a highly reliable system and processes in the healthcare industry is a classic conundrum. As safe and quality healthcare has its increasing complexity, where errors are more likely to occur. Hence, most healthcare organizations have promoted the practice of Just Culture. The research study quantified and explained key aspects on the strengths and weaknesses of just culture dimensions which facilitated understanding in implementing a safety culture in Hamad General Hospital (HGH).
Design:
Perception was measured using the adapted JCAT through a descriptive, cross- sectional research design. Independent T-tests and One-way ANOVA were used to investigate the relationship between the demographic profile and just culture perception among 212 staff nurses in HGH.
Results
A strong positive perception among the staff nurses of Just Culture was found out based on its six (6) dimensions in Medical and Surgical In-Patient Units of HGH. Positive response rate is highest at Continuous Improvement dimension which is 88.66%. Balance dimension received the lowest rating with only 52.31% positive response rate.
Impact of COVID-19 on routine immunization in Oyo State, Nigeria: Trend analysis of immunization data in the pre-and post-index case period; 2019 – 2020
Authors: Babatunde Olaniyan Akintunde , Olatunji Muideen Babatunde , Omotajo Olugbade Robertson , Ikwunne Olukorede Ifedolapo , Babatunde Adekunbi Mofoyeke , Titilayo Nihinlola Eunice , Funmilayo Patrick Grace , Dairo David Magbagbeola 
Published: March 2021

Abstract
Background
The response to COVID-19 pandemic has posed new obstacles to the fragile health system, most especially in the area of vaccination across much of Africa. As the response to the pandemic intensifies through the application of non-pharmacologic interventions as well as enforcement of the lockdowns across African cities, there is a significant risk that more children will miss out on life-saving vaccines that can prevent childhood killer diseases. This study was therefore conducted to look at the impact of COVID-19 pandemic on routine immunization in Oyo State, Nigeria.
Method:
We conducted a descriptive secondary analysis of immunization data between July 2019 and August 2020. These data were retrieved from the Monitoring and Evaluation Unit of Oyo State Primary Health Care Board. The data were extracted from the original paper format and entered into Excel sheets. Line graphs were plotted to compare the trends of the coverage rates before and after the index case of COVID-19 pandemic.
Results
The average coverage rates for BCG before and after index case was 85.8% and 82.1% respectively, while it was 63.5% and 60.0% for HBV0. For the co-administered vaccines at 14 weeks, Penta 3, OPV 3, PCV 3 and IPV coverage rates dropped from 76.1%, 75.4%, 75.1% and 73.5–72.0%, 71.4%, 72.0% and 71.9% respectively. The average coverage rates for yellow fever and measles dropped sharply from 77.0% and 74.5–64.6% and 58.6% respectively. The average drop-out rates for the pre-and post-index case periods were 5.0% and 4.7% respectively. For the planned fixed and outreach sessions, none of the monthly sessions met the target of 100.0% in the post-index case period.
Conclusion
Decreased vaccination coverage for vaccine-preventable diseases could cause parallel outbreaks with COVID-19 and further exacerbate the strain on health systems attempting to end the acute phase of this pandemic. Therefore, as the dramatic second wave unfolds, the Government of Nigeria must take deliberate steps to strike a balance between a fresh lockdown and the imperative of uninterrupted social service. In this wise, it must remain committed to a timely vaccination programme
Does economic development widen or narrow the gap&nbsp;of public health service utilization&nbsp;among&nbsp;different subgroups of internal migrants?&nbsp;Evidence from the China Migrant Dynamic Survey in 2017
Authors: Yang Zhen , Jiang Chenghua 
Published: March 2021

Abstract
Background: China is promoting the equalization of National Essential Public Health Services (NEPHS) for the internal migrants (IMs). Studies have analyzed the impact of migration range (MR) and regional economic development level (REDL) on the IMs' NEPHS utilization (NEPHSU), but no studies have explored the interaction of MR and REDL on it.Methods: Data from the China Migrant Dynamic Survey of 2017, involving 122656 IMs. Per capita GDP was set as the indicator for REDL, and 28 provinces were divided into three groups according to REDL: affluent, medium and poor. The MR was divided into inter-province and intra-province, and social capital (SC) was distinguished into cognitive (CSC) and structural social capital (SSC). Awareness of NEPHS (ANEPHS) and establishment of health record (EHR) were selected as indexes of NEPHSU. Multiple line charts and hierarchical logistic regression were used to investigate the interaction of MR, REDL and SC on NEPHSU.Results: (1) The socioeconomic status (SES) and social capital (SC) of inter-provincial IMs were significantly lower than those of intra-provincial IMs, and the gap was most prominent in affluent areas. (2) From low to high, the NEPHSU of inter-provincial IMs was ranked as affluent, medium and poor, while the corresponding order of intra-provincial IMs was medium, poor and affluent areas, and the gap of NEPHSU between inter-provincial and intra-provincial IMs was the largest in affluent areas. (3) SC could significantly promote the IMs' NEPHSU, but there was a gap between inter-provincial and intra-provincial IMs, and the gap was the largest in affluent areas.Conclution: REDL can significantly affect the gaps of SES and SC among subgroups of IMs with different MR. Inter-provincial migrants in affluent areas have relatively lower SES and SC, which may be a major barrier to their access to NEPHS, and the government should pay special attention to this vulnerable group when promoting equalization of NEPHS for IMs.
A simple reverse genetics method to generate recombinant coronaviruses&nbsp;
Authors: Mélade Julien , Piorkowski Géraldine , Touret Franck , Fourié Toscane , Driouich Jean-Sélim , Cochin Maxime , Bouzidi Hawa Sophia , Coutard Bruno , Nougairède Antoine , de Lamballerie Xavier 
Published: March 2021

Abstract
Engineering recombinant viruses is capital for deciphering the biology of emerging viral pathogens such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the large size of coronaviruses genome makes reverse genetics methods challenging.Here we describe a simple method based on “infectious subgenomic amplicons” (ISA) technology to generate recombinant infectious coronaviruses with no need for reconstructing a full genomic cDNA. The method was applied to the SARS-CoV-2 and the feline enteric coronavirus, and allowed to rescue wild-type viruses with biological characteristics closely similar to original strains. Mutations and fluorescent red reporter gene were rapidly incorporated into the SARS-CoV-2 genome allowing the generation of a genomic variant and a fluorescent reporter strains which were studied during in vivo experiments, serological diagnosis and antiviral assays. The swiftness and simplicity of the ISA method has the potential to facilitate the advance of coronavirus reverse genetics studies and to explore biological properties of SARS-CoV-2 variants or accelerating the development of therapeutic measures.
Evaluation of spatial–temporal characteristics of precipitation using discrete maximal overlap wavelet transform and spatial clustering tools
Authors: Roushangar Kiyoumars , Moghaddas Mohsen , Ghasempour Roghayeh , Alizadeh Farhad 
Published: March 2021

Abstract
In the present study, classical and proposed methods were used to investigate the monthly precipitation characteristics of 30 stations in the southeastern United States during 1968–2018. Maximal overlap discrete wavelet transform (MODWT) as preprocessing method and K-means clustering method were used. First, the monthly precipitation time series of stations were decomposed into several subseries using MODWT and considering db as the mother wavelet. Then, the energy values of theses subseries were calculated and used as inputs in K-means and radial basis functions (RBF) methods. The optimum number of clusters obtained for the considered stations in both classical and proposed methods was five clusters. In order to use the data as the input of the RBF method, the data correlation was evaluated by variogram. Based on the results of clustering and in accordance with the latitude and longitude variations of the stations, it was found that with increasing the energy of the clusters, the amount of precipitation in the stations decreased and vice versa. The silhouette coefficient of clustering for the classical method obtained was 0.3 and for the proposed method it was 0.8, which indicates better clustering of the selected area using the proposed method.