bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paris, « un lieu centre de tous les centres ». Est-ce toujours d’actualité ?
Authors: Le Baillif Anne-Marie 
Published: January 2021

Paris, “The Centre of All Centres”. Is It Still the Case? In La République Mondiale des Lettres published in 1999 and 2008, Ms. Casanova wrote: “Paris is the Greenwich meridian for literature” for the 19th and 20th centuries. Writers and artists have come to the city in the past because it was extremely attractive for creative and economic reasons. But at the beginning of the 21st century, with the rise of the New Media for writing, publishing and diffusing, is it correct to say that Paris is still supreme? Is location more important than the time devoted to writing and reading?
The claims on which Ms. Casanova builds her assertions are not supported by the facts of recent history and geography. She refers to “La belle santé économique et la liberté” in Paris but she forgot to mention why artists came from central Europe. It was just because the life was cheaper in Paris than in Berlin, as Walter Benjamin observed in 1926. She notes that Paris was the world centre for high fashion and that writers came together there to be inspired by the place and each other. But these things are no longer true: Paris is one of the most unaffordable cities in the world. Fashion in clothes is determined in many centres, with fashion weeks held in New York, Milan and China; aesthetics no longer depend on a single country. Literary creativity has spread across many continents and the internet and social media provide access to millions of people around the globe. Globalisation has unified the world, note Jean-Philippe Toussaint and Sylvain Tesson, and brought the standardization of cultures.
There is also the matter of the dominant language today. The French language has not changed since Ms. Casanova was doing her research, but French writers now dream of being translated into English to reach the largest audience around the world. Publishers also favour English to make the most profit because literature and art are now worldwide commodities. Writers and researchers use the Internet, which connects them with documents, libraries and people all over the world. Newspapers such as Le Monde and Le Figaro in France provide literary reviews from around the world; for example, Histoire de la Traduction Littéraire en Europe Médiane, compiled by Antoine Chalvin, Marie Vrinat-Nikolov, Jean-Léon Muller and Katre Talviste, was written up in Cahiers Littéraires du Monde. What about the readership? If publishing and merchandizing are accelerating and globalizing because of how the Internet changes time and distance, the writer still has to follow the rhythm of the subject.
CRISPR/Cas9 mediated knock-out of VPREB1 gene induces a cytotoxic effect in myeloma cells
Authors: Khaled Mai , Moustafa Amr S. , El-Khazragy Nashwa , Ahmed Maha Imam , Abd Elkhalek Marwa Ali , El_Salahy Eman M. 
Published: January 2021

Background
Multiple Myeloma (MM) is a heterogeneous, hematological neoplasm that accounts 2% of all cancers. Although, autologous stem cell transplantation and chemotherapy are currently the most effective therapy, it carries a notable hazards, in addition for being non curative. Recently, the Clustered Regular Interspaced Short Palindromic Repeats (CRISPR-cas9) has been successfully tried at the experimental level, for the treatment of several hematological malignancies.

Objectives
We aimed to investigate the in-vitro effect of CRISPR-cas9-mediated knock-out of V-set pre B-cell surrogate light chain 1”VPREB1” gene on the malignant proliferation of primary cultured myeloma cells.

Methods
Bioinformatics’ analysis was performed to explore the gene expression profile of MM, and the VPREB1 gene was selected as a target gene for this study. We knocked-out the VPREB1 gene in primary cultured myeloma cells using CRISPR-cas9, the VPREB1 gene editing efficacy was verified by determining VPREB1 gene expression at both the mRNA and protein levels by qPCR and immunofluorescence, respectively. Furthermore, the cytotoxic effect on primary myeloma cells proliferation was evaluated using cytotoxicity assay.

Results
There was a statistically significant reduction of both VPREB1 mRNA and protein expression levels (p<0.01). knock-out of VPREB1 gene in myeloma cell line resulted in a statistically significant reduction of myeloma cell proliferation.

Conclusion
CRISPR-cas9-mediated knock-out of VPREB1 gene is effective for inhibiting the proliferation of primary myeloma cells. This would provide a basis for a promising therapeutic strategy for patients with multiple myeloma.
Evaluation of Soybean Varieties for Oxalate, Phytate and Polyunsaturated Fatty Acids Content
Authors: Francis Ameh , Luper Tsenum Joseph , Gbamwuam Dooshima Elizabeth 
Published: January 2021

Various studies have been carried out on the composition of phytate, and polyunsaturated fatty acids in soybeans while very limited information is available on oxalate composition of soybean seeds. Due to the great potential of soybean in the global market with its attendant importance of edible cum-therapeutic oil to man and livestock as well as its valuable usage in industries, all available information both qualitative and quantitative should be used in making decisions about the food value of these soybean varieties.
The findings indicated significant levels of linoleic and linolenic acid with the exception of TGX-1987-10F with no peak in the result. The phytate composition of these soybean varieties are safe while the oxalate levels could pose a threat to human health particularly individuals diagnosed of kidney stones or hyperoxaluria. The oil obtained from these soybean cultivars are also less prone to auto-oxidation that is characteristic of most soybean oil due to high composition of polyunsaturated fatty acids which causes rancidity and off flavor thereby lowering their shelf life.
Особенности использования цикла президентских выборов для прогнозирования преобладающей тенденции на фондовом рынке США
Authors: Benenson Olga 
Published: January 2021

Цель работы – установить особенности проявления социально-экономической циклической закономерности «Цикл президентских выборов» на фондовом рынке США в современных условиях и разработпть рекомендации по практическому применению этой закономерности при осуществлении инвестиционной деятельности.
Дизайн/Метод/План исследования. Статистическая обработка данных о значениях промышленного индекса Доу-Джонса за период с 1887 по 2020 гг.
Результаты исследования. Исследование показало, что закономерности по величине среднего прироста индекса Доу-Джонса в разные года цикла Президентских виборов в условиях современной экономики отличаются от закономерностей, существовавших до 1993 года. В настоящее время практический интерес может представлять только год, предшествующий выборам президента США, когда средний прирост индекса в 2-4 раза превышает прирост в другие годы цикла. Известный ранее тезис о том, что при правящей Демократической партии фондовый рынок США растет быстрее, подтверждается и в условиях современной экономики. Тем не менее, с каждым годом разница между приростами рынка при различных партиях сглаживается. В рамках «Цикла президентских выборов» существует стойкая закономерность, заключающаяся в том, что индекс Доу-Джонса вырастает от своего минимального значения в «промежуточный» год до максимального значения следующего, предвыборного года. При этом, в последние десятилетия величина процента прироста имеет тенденцию к уменьшению, и если раньше, с 1914 по 2011 гг. его среднее значение составляло 47-48,6 %, то в период с 1993 по 2020 гг. процент прироста уменьшился до 36,7 %.
Практическое значение исследования. Практическое применение результатов исследования даст возможность повысить точность прогнозирования преобладающих тенденций на международных фондовых рынках и, соответственно, повысить эффективность инвестирования.
Оригинальность/Ценность/Научная новизна исследования. настоящее исследование расширяет знания об особенностях проявления и использования циклической закономерности «Цикл президентских выборов», предлагает обновленную модель его использования при прогнозировании преобладающей тенденции на фондовом рынке США. Результаты исследования могут быть интересны специалистам, работающим в сфере инвестирования на международных финансовых рынках.
Ограничение исследования/Перспективы дальнейших исследований. Результаты исследований, приведенные в настоящей статье, создают основу для проведения аналогичных исследований для европейских и азиатских финансовых рынков, а также выявления и исследования других циклических закономерностей на международных финансовых рынках с целью разработки прикладных механизмов инвестирования, способствующих повышению эффективности инвестирования.
Тип статьи – эмпирический.
Age discrimination at work and some reflections from job ads: The case of Turkey
Authors: Man Fuat 
Published: January 2021

Purpose – to analyze the situation of age discrimination at work and to give some reflections from job ads in the case of Turkey.
Design/Method/Approach of the research. This study presents a limited depiction of age discrimination occurring in Turkey by analyzing job ads.
Findings. One of the most critical demographic issues for the entire world, especially for the advanced world, is aging. It is essential as it necessitates some critical regulations that have economic and social consequences. During this aging trend, job seekers over a certain age in labor markets face age discrimination. Although many countries, both developed and developing, have some legal regulations against age discrimination, it remains a crucial form of discrimination. Where we can easily see this kind of discrimination is job ads. This study examined more than fifteen hundred job ads posted by İŞKUR, state-affiliated Employment Agency of Turkey, for the cities of Marmara Region of Turkey were examined. Nearly 20% of all job ads is indicating some statement for age limit.
Research limitations/Future Research. Although just the age value indicated by employers in the ads itself does not mean an absolute age discrimination rate, 20 % is a vital implication for that kind of discrimination, and also, this figure implies the need for detailed further studies.
Paper type – empirical.
Prevalence of allergic disorders and risk factors associated with food allergy in Turkish preschoolers
Authors: Aksoy Ayşen Genç , Boran Perran , Karakoc-Aydiner Elif , Gokcay Gulbin , Ulker Tamay Zeynep , Devecioglu Esra , Baris Safa , Ozen Ahmet 
Published: January 2021

Background: The prevalence of allergic disorders is on the rise, affecting about 10% of the population. In this retrospective cohort, we investigated prevalence of allergic disorders, associated risk factors, and the outcome of food allergies.
Material and methods: We analyzed data from birth cohorts of two university hospitals’ well-child outpatient clinics. Factors related to onset and type of allergic diseases were assessed from demographic, socioeconomic, and clinical data.
Results: Analyses were performed on 949 (431F/518M) infants at a mean current age of 28±6 months. Any allergic disease was established among 177 cases (22%); atopic dermatitis in 123 (12.8%), respiratory allergies in 55 (5.7%), and food allergy in 41 (4.3%). The risk for allergic disorders was found to be significantly increased for male gender (OR: 2.31, 95% CI; 1.54–3.46), and positive parental atopy (OR: 1.94, 95% CI; 1.31–2.86). The risk of food allergies was significantly higher in the male gender (OR: 2.47, 95% CI; 1.21–5.02), who consumed egg-white between 6 and 12 months (OR: 2.34, 95% CI; 1.22–4.48), and who were formula-fed before 6 months (OR: 2.16, 95% CI; 1.14–4.10). We found no significant association between the rate of food allergy outgrowth or food induced-anaphylaxis with regards to the timing of introducing egg-white into the diet.
Conclusions: Although the introduction of egg-white into infant diet at 6–12 months of life appeared as an independent risk for any food allergy, none of the patients developed anaphylaxis. Age at symptom onset and outgrowing food allergy were similar compared to those introduced egg-white after 12 months. We recommend promoting exclusive breastfeeding during the first 6 months of life, and avoidance of prolonged restrictive diets for children with food allergy.
The main prognostic factors influencing the results of the superior tarsal muscle resection in patients with blepharoptosis
Authors: Goltsman Elena V. , Potemkin Vitaly V. , Davydov Dmitriy V. 
Published: January 2021

Transconjunctival methods of ptosis correction gain popularity nowadays. The wide use of the technique is limited because of the lack of clear recommendations regarding the volume of the resection, especially in patients with negative phenylephrine test.
Purpose. To assess the influence of main predictive factors on superior tarsal muscle (STM) resection result.
Materials and methods. Patients were divided into two groups according to the result of phenylephrine test (PE). Patients with positive results were included in the first group, with negative and weak results in the second group. All patients underwent STM resection according our new algorithm.
Results. The result of STM resection was influenced by PE test and intraoperative white line motility test (WLM), but not by levator function and the amount of superior tarsal muscle resection.
Conclusions. PE and WLM tests play main role in choosing a method for blepharoptosis correcting.
Widening of sternoclavicular joint distances in blunt chest trauma
Authors: ÇAKMAK Vefa , TÜRKOĞLU Sefa , ÖZEN Mert , ÇAKMAK Pınar 
Published: January 2021

Purpose: Blunt chest trauma has high mortality and morbidity rates. The aim of this study was to evaluate the relationship between trauma findings and sternoclavicular joint (SCJ) distances in patients with blunt chest trauma.
Materials and Methods: Between May 2019- September 2019, Thorax Computed Tomography (CT) images of 102 patients (78 males, 24 females, aged 19-88 years) with blunt chest trauma were evaluated retrospectively. Rib fractures, costal cartilage fractures and other signs of trauma were evaluated. SCJ distances were measured at the inferior, mid, and superior segments in the coronal reformatted CT images. Post-traumatic SCJ expansion was evaluated in patients with rib and costal cartilage fractures. Additionally, SCJ and the presence of other post-traumatic signs were compared. An inter-observer reliability analysis with Intraclass correlation coefficient (ICC) scores with 95% CIs were calculated.
Results: In the presence of fractures of 1st to 4th ribs a statistically significant widening of superior and mid segments of the ipsilateral SCJs were detected. A 2-mm or greater difference of widening of the superior segment of the ipsilateral SCJ compared to the contralateral joint was found statistically significant for hemothorax, pneumothorax, and wall emphysema. The inter-observer agreement was excellent for the measurements of the SCJ on coronal plane, having an ICC score ranging from 0.921 to 0.961 (95% CI).
Conclusion: The expansion of the ipsilateral SCJ distances in rib fractures in the upper part of the chest wall shows that SCJ performs an important role in the absorption of energy to the chest wall.
Clinical, hormonal, radiological and morphological comparison of patients with clinically evident Cushing's disease and patients with silent corticotroph cell adenoma
Authors: AKKUŞ Gamze , KARAGÜN Baris , ÇETİNALP Nuri Eralp , AÇIKALIN Arbil , ODABAŞ Fulya , EVRAN OLGUN Mehtap , SERT Murat , ZORLUDEMİR Suzan , TETİKER Bekir Tamer 
Published: January 2021

Purpose: The aim of the study was to review our clinical 7 years experiences with silent corticotroph adenoma (SCA) and Cushing disease (CD) with regard to clinical, radiological features, immunohistochemical and surgical outcomes and compare the results between two groups.
Material and Methods: We retrospectively reviewed a series of patients (n=17; SCA 10, CD 7) with corticotroph adenomas and collected biochemical, neuroradiological and pathological data of those during follow-up time.
Results: Mean pre-operative ACTH values of the patients with CD and SCA were 60.4±29.5, 45.5±34.6 pg/mL, respectively. Mean preoperative cortisol of the patient with CD (21.2±4.4 vs 11.5±4.0 mcg/dL) was increased than the patients with SCA measurements’. Patients with SCA had larger pituitary mass (20.4±4.5 vs 8.8±4.0 mm) than the patients with CD. And cavernous sinus invasion also was determined in all patients with SCA. Sparsely granulation staining was more common in all patients with SCA (7/10) or CD (4/7).
Conclusion: SCAs are totally different from functional CD adenomas related with clinical characteristics and postoperative outcomes. SCA can be thought of as a diverse group of pituitary adenomas.
Can blood eosinophil to basophil ratio, eosinophil to lymphocyte ratio and basophil to lymphocyte ratio predict the severity of intrahepatic cholestasis in pregnancy?
Authors: KANZA GÜL Derya , ŞOLT Ayça 
Published: January 2021

Purpose: The purpose of the study was to investigate the relation between inflammatory markers used for allergic diseases and intrahepatic pregnancy cholestasis (ICP).
Materials and Methods: In this retrospective case-control study, a total of 114 intrahepatic pregnancy cholestasis patients; 87 with mild cholestasis (group 1) and 27 with severe cholestasis (group 2) and 292 healthy pregnant women in the control group (group 3) were included in the study. The basophil, eosinophil, eosinophil-basophil ratio (EBR), eosinophil-lymphocyte ratio (ELR) and basophil-lymphocyte ratio (BLR), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) values used in this study.
Results: Significant differences were detected between groups in terms of ELR, NLR and PLR values. ELR, NLR, PLR values were significantly higher in the mild cholestasis group than in the control group. To predict the pregnancy cholestasis, receiver operating characteristic curve (ROC) analysis was made, which yielded 76.3% sensitivity and 56.1% specificity when ELR’s interrupt value was 0.2243, NLR interrupt value 11.27% when sensitivity was 70% and specificity 54,000 2%, and PLR cut-off value was 194.46 when sensitivity was 60% and specificity was 58%.
Conclusion: Serum inflammation markers and allergy markers may be diagnostic in intrahepatic pregnancy cholestasis; however, they are not decisive in determining the severity of the disease.
Meta-analysis of various tki generations efficacy either alone or in combinations in EGFR mutated NSCLC
Authors: Moiseenko F.  V. , Bogdanov A. A. , Volkov N. . M. , Zhabina A.   S. , Fedyanin M. Yu. 
Published: January 2021

Background. Multiple options of first line treatment in patients with EGFR mutated NSCLC are registered worldwide and, in particular, in Russia. The individual choice for every patient is still based primarily on personal preference of a particular physician and financial possibilities of the region, since no stratification factors are available. At the same time large randomized trials comparing various options are hardly possible in this narrow biomarker restricted population. The additional information on advantages in particular subgroups obtained via indirect comparison might be an important argument. Materials and methods. We conducted meta‑analysis of trials studying various approaches in first line EGFR mutated NSCLC cancer. Results. Our meta‑analysis revealed unequal influence of different treatment approaches on OS according to clinical stratification factors. In females (HR 0.79, 95 % CI 0.63–0.99; p = 0.04), patients younger than 65 y. o. (HR 0.66, 95 % CI 0.52–0.83; p = 0.0004), with exon 21 mutations (HR 0.76, 95 % CI 0.59–0.99; p = 0.04) and ECOG 1 (HR 0.72, 95 % CI 0.59–0.89; p = 0.002) OS benefit can be achieved with 2nd generation TKI. In the rest of patients (males, ECOG 0, ex19 deletions) increase in OS necessitates more aggressive treatment with TKI and chemotherapy combination (HR 0.57, 95 % CI 0.41–0.79; p = 0.0008). No influence on OS was observed for TKI and angiogenesis inhibitors. Interestingly, the observed advantage in OS and PFS was not accompanied by response that did not differ between regimens (OR 1.55, 95 % CI 0.86–2.80; p = 0.14).Conclusions. We showed the importance of individualized approach in the first line EGFR mutated NSCLC selection. Our results underline the need for the new data on various approaches comparison.
Is it necessary to add anti-angiogenic therapy to chemotherapy in patients with metastatic colorectal cancer and BRAF mutation? The systematic review and meta-analysis results
Authors: Fedyanin M. Yu. , Polyanskaya E. M. , Elsnukaeva H. H M. , Tryakin A. A. , Pokataev I. А. , Ignatova Е. О. , Sergeev U. S. , Bulanov A. A. , Tjulandin S. A. 
Published: January 2021

Introduction: targeted anti‑angiogenic drugs are the integral component of systemic therapy for metastatic colorectal cancer. To date, there have been no prospective studies that would directly answer the question of the need to add anti‑ angiogenic agents to chemotherapy for BRAF‑mutated metastatic colorectal cancer. We performed a systematic review and meta‑analysis to evaluate the efficacy of adding anti‑angiogenic therapy to chemotherapy in patients with metastatic colorectal cancer harboring a mutation in the BRAF gene. Materials and methods: We searched for articles and abstracts in the PubMed, ASCO and ESMO databases, published before September 2020 and containing information on the results of prospective randomized trials comparing the combination of anti‑angiogenic agents (bevacizumab, aflibercept or ramucirumab) in the first‑or second‑line therapy for metastatic colorectal cancer, which indicate the efficacy depending on the presence of mutations in the BRAF gene. The primary endpoint was the risk ratio (RR) for progression or death with a 95 % confidence interval (95 % CI). The meta‑analysis was carried out using the Review Manager, version 5.3.Results: 4 studies met the selection criteria (AVF2107 g, AGITG MAX, VELOR and RAISE), which included data from 120 patients with the BRAF mutation, 65 (54 %) patients received a combination of chemotherapy with an anti‑angiogenic agent, and 55 (46 %) patients received only chemotherapy. The meta‑analysis showed improved progression‑free survival (RR 0.64, 95 % CI 0.4–1.02; p = 0.06; I 2 = 0 %, p for heterogeneity = 0.7; 3 studies) and overall survival (RR 0.51, 95 % CI 0.32–0.82; p = 0.005; I 2 = 0 %, p for heterogeneity = 0.54; 4 studies) in the group treated with anti‑angiogenic agents.Conclusions: the combination of chemotherapy with anti‑angiogenic agents in the first‑or second‑line therapy improves progression‑free survival and overall survival in patients with BRAF‑mutated metastatic colorectal cancer. Prospective randomized trials in this patient population are needed to determine the optimal first‑line treatment regimen.