bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of defibrillation on the performance of an implantable vagus nerve stimulation system
Authors: Libbus Imad , Stubbs Scott R. , Mazar Scott T. , Mindrebo Scott , KenKnight Bruce H. , DiCarlo Lorenzo A. 
Published: March 2021

Abstract
Background
Vagus Nerve Stimulation (VNS) delivers Autonomic Regulation Therapy (ART) for heart failure (HF), and has been associated with improvement in cardiac function and heart failure symptoms. VNS is delivered using an implantable pulse generator (IPG) and lead with electrodes placed around the cervical vagus nerve. Because HF patients may receive concomitant cardiac defibrillation therapy, testing was conducted to determine the effect of defibrillation (DF) on the VNS system.

Methods
DF testing was conducted on three ART IPGs (LivaNova USA, Inc.) according to international standard ISO14708-1, which evaluated whether DF had any permanent effects on the system. Each IPG was connected to a defibrillation pulse generator and subjected to a series of high-energy pulses.

Results
The specified series of pulses were successfully delivered to each of the three devices. All three IPGs passed factory electrical tests, and interrogation confirmed that software and data were unchanged from the pre-programmed values. No shifts in parameters or failures were observed.

Conclusions
Implantable VNS systems were tested for immunity to defibrillation, and were found to be unaffected by a series of high-energy defibrillation pulses. These results suggest that this VNS system can be used safely and continue to function after patients have been defibrillated.
The Effect of Multichannel and Omnichannel Retailing on Physical Stores
Authors: Gao Fei , Agrawal Vishal V. , Cui Shiliang 
Published: March 2021

Most retailers today sell products through an online channel in addition to traditional physical stores. We investigate how such a multichannel or omnichannel retailer should decide the number and size of physical stores. We show that a higher return rate for online purchases can incentivize the retailer to have fewer physical stores that are larger in size. As online shopping becomes more convenient, a retailer may prefer to have more physical stores that are smaller in size. We also study the effect of three popular omnichannel strategies that involve changes of the physical stores’ functions: (i) showrooms only display products for customers to inspect before they purchase online, removing fulfillment from physical stores; (ii) return flexibility expands the functionality of physical stores by allowing customers to return online orders at them; and (iii) fulfillment flexibility expands functionality by allowing customers to pick up products purchased online at physical stores. We show that when the physical stores are given fewer (more) functions, as with the showroom (return or fulfillment flexibility) strategy, the omnichannel retailer may find it optimal to increase (reduce) the number and/or size of the physical stores.This paper was accepted by Vishal Gaur, operations management.
Photonic solution to phase sensing and control for light-based interstellar propulsion
Authors: Bandutunga Chathura P. , Sibley Paul G. , Ireland Michael J. , Ward Robert L. 
Published: March 2021

Reaching another star system within a human timescale requires traveling at a sizeable fraction of the speed of light. To achieve this, the Breakthrough Starshot program proposes a ground-based laser array to accelerate a gram-scale spacecraft through photon radiation pressure, requiring of order 100 GW of continuous wave optical power. The coherent combination of many lasers is one avenue to achieve a high optical power output. Here we present a photonic solution for optical phase sensing and control to enable the coherent combination of order

10
8

individual lasers, including the ability to sense and compensate for atmospheric distortions, assuming the laser system is ground based.
Propagation characteristics of a ring Airy vortex beam in slant atmospheric turbulence
Authors: Yong Kangle , Tang Shanfa , Yang Xiaomin , Zhang Rongzhu 
Published: March 2021

In this paper, the propagation characteristics of a ring Airy vortex beam (RAVB) in
slant atmospheric turbulence are studied. The effects of some key
parameters, such as the truncation factor, the zenith angle, and the
propagation distance, on the propagation characteristics of RAVB are
analyzed. The results show that the beam quality becomes worse with an
increase in the propagation distance, zenith angle, and truncation
factor. When the propagation distance exceeds 3 km in turbulence, the
value of the aperture-averaged scintillation index will reach the peak
value. On the other hand, the mean signal-to-noise ratio of this beam
will be affected by the propagation distance. The beam quality can be
improved by increasing the topological charges. When the truncation
factor is 0.1, RAVB performs best when the distance is long.
Comprehensive vector analysis for electro-optical, opto-electronic, and optical devices
Authors: Qing Ting , Li Shupeng , Tang Xiaohu , Li Ping , Chen Xufeng , Wang Lihan , Fang Yijie , Cao Meihui , Wu Lugang , Pan Shilong 
Published: March 2021

High-performance electro-optical (E-O), opto-electronic (O-E), and optical (O-O) devices are widely used in optical communications, microwave photonics, fiber sensors, and so on. Measurement of the amplitude and phase responses are essential for the development and fabrication of these devices. However, the previous methods can hardly characterize the E-O, O-E, and O-O devices with arbitrary responses. Here we propose a comprehensive vector analyzer based on optical asymmetrical double-sideband (ADSB) modulation to overcome this difficulty. The ADSB solves the problem of frequency aliasing and can extract information from both the

+

1

st- and

−

1

st-order sidebands. Thus, most devices in photonic applications, including phase modulators, can be characterized. In the experiment, a commercial photodetector, a phase modulator, and a sampled FBG are used as the O-E, E-O, and O-O devices under test, respectively. A frequency resolution of 2 MHz, an electrical sweeping range of 40 GHz, and an optical sweeping range of 80 GHz are achieved.
Single-sweep volumetric optoacoustic tomography of whole mice
Authors: Kalva Sandeep Kumar , Dean-Ben Xose Luis , Razansky Daniel 
Published: March 2021

Applicability of optoacoustic imaging in biology and medicine is determined by several key performance characteristics. In particular, an inherent trade-off exists between the acquired field-of-view (FOV) and temporal resolution of the measurements, which may hinder studies looking at rapid biodynamics at the whole-body level. Here, we report on a single-sweep volumetric optoacoustic tomography (sSVOT) system that attains whole body three-dimensional mouse scans within 1.8 s with better than 200 μm spatial resolution. sSVOT employs a spherical matrix array transducer in combination with multibeam illumination, the latter playing a critical role in maximizing the effective FOV and imaging speed performance. The system further takes advantage of the spatial response of the individual ultrasound detection elements to mitigate common image artifacts related to limited-view tomographic geometry, thus enabling rapid acquisitions without compromising image quality and contrast. We compare performance metrics to the previously reported whole-body mouse imaging implementations and alternative image compounding and reconstruction strategies. It is anticipated that sSVOT will open new venues for studying large-scale biodynamics, such as accumulation and clearance of molecular agents and drugs across multiple organs, circulation of cells, and functional responses to stimuli.
Differences between cancer patients and others who use medicinal Cannabis
Authors: Cousins Matthew M. , Jannausch Mary , Jagsi Reshma , Ilgen Mark 
Published: March 2021

Background
Cancer patients have been at the forefront of policy discussions leading to legalization of medical Cannabis (marijuana). Unfortunately, Cannabis use among those with cancer is poorly understood.

Methods
A diverse group of patients seeking certification for medical Cannabis in the state of Michigan were surveyed at the time of their presentation to medical dispensaries. The survey assessed demographics, employment/disability, pain, physical functioning, mental health, mode of Cannabis use, and frequency/amount of Cannabis use. Chi-square and t-tests were performed to compare those who did and did not endorse cancer diagnosis.

Results
Analysis of data from 1485 adults pursuing medical Cannabis certification, including 72 (4.8%) reporting a cancer diagnosis, indicated that those with cancer were older [mean age 53.4 years (SD = 10.5) vs. 44.7 years (SD = 13.0); p<0.001] than those without cancer. They also differed regarding employment status (p<0.001; working: 20.8% vs. 46.2%; disabled: 44.4% vs. 26.5% for those with vs. those without cancer, respectively). Those with cancer used less Cannabis (p = 0.033 for quantity used) and used Cannabis less often (p = 0.032 for frequency of use); they less frequently endorsed smoking Cannabis (80% vs 91%; p = 0.015). There was a non-significant trend to increased edible use in those with cancer (57% vs. 44%; p = 0.052).

Conclusions
Patients with cancer who are seeking medical Cannabis are different from those seeking medical Cannabis without cancer, and they report using Cannabis differently. Further research to characterize the patterns and consequences of Cannabis use in cancer patients is needed.
The Art of Screen Adaptation: Top Writers Reveal Their Craft, Alistair Owen (2020)
Authors: Gist Christopher 
Published: March 2021

Review of: The Art of Screen Adaptation: Top Writers Reveal Their Craft, Alistair Owen (2020)
Harpenden: Old Castle Books Ltd., 288 pp.,
ISBN 978-0-85730-227-4, p/bk, £18.99
ISBN 978-0-85730-228-1, ebook, £7.59
The Notorious Ben Hecht: Iconoclastic Writer and Militant Zionist, Julien Gorbach (2019)
Authors: Tieber Claus 
Published: March 2021

Review of: The Notorious Ben Hecht: Iconoclastic Writer and Militant Zionist, Julien Gorbach (2019)
West Lafayette, IN: Purdue University Press, 504 pp.,
ISBN 978-1-55753-865-9, h/bk, $32.95

Ben Hecht: Fighting Words, Moving Pictures (Jewish Lives), Adina Hoffman (2019)
New Haven, CT: Yale University Press, 264 pp.,
ISBN 978-0-30018-042-8, h/bk, $26
Da criação ao Roteiro: Teoria e Prática (‘From creation to script: Theory and practice’), 5th ed., Doc Comparato (2018)
Authors: Davino Glaucia 
Published: March 2021

Review of: Da criação ao Roteiro: Teoria e Prática (‘From creation to script: Theory and practice’), 5th ed., Doc Comparato (2018)
Sao Paulo, SP: Summus Editorial, 720 pp.,
ISBN 978-8-53231-113-9, p/bk, $84.87
No matter who: What makes one a relativist?
Authors: Pérez-Navarro Eduardo 
Published: March 2021

As part of her argument that relativism and contextualism are nothing but notational variants of each other, Stojanovic holds that contextualism is flexible enough to achieve whatever relativism might do if the matter is what truth-value is assigned to each pair of sentence and context. In this paper, I reply to this statement by arguing that contextualism cannot be made as flexible as relativism without in fact turning it into a version of relativism. The key to my response to Stojanovic is that, while relativism relativizes utterance truth, contextualism does not, so parameters that are not fixed at the context of utterance will be accessible for the relativist, but not for the contextualist. Although the relativity of utterance truth follows as soon as propositional truth is relativized to contexts of assessment, as the relativist does, it is easy to lose sight of this fact if we identify the context of assessment with the assessor’s context. Hence, the point of this paper is that the difference between relativism and contextualism is not one as to whose parameters play a role in determining the sentence’s truth-value. If it were, contextualism could indeed be made just as flexible as relativism.
Prioritization of Patients in ICU: Composite Approach of Multiple-Criteria Decision-Making and Discrete Event Simulation
Authors: Davodabadi Afsaneh , Daneshian Behrooz , Saati Saber , Razavyan Shabnam 
Published: March 2021

Goal: This article aims to present a systematic approach to improve the resource allocation and human queues prioritization patterns.
Design / Methodology / Approach: To achieve such a purpose, effective criteria using a fuzzy-Delphi method, and subject-related researchers’ views were obtained. Utilizing the Analytic Network Process method, the weights of each criterion was measured. Then, considering the established weights and using a fuzzy-TOPSIS method, a prioritization system via Discrete Event Simulation was developed.
Results: Results indicate that the established approach properly improved the performance of the prioritization system in terms of resources and facilities allocation in neurology’s ICUs.
Limitations of the investigation: A drawback of this research can be in states of emergency which limits the options at hand and the criteria proposed may set a drawback on the aim of the study.
Practical implications: The results show that the proposed model can modify patient entry based on multiple criteria in terms of productivity and social justice in the patient queuing strategy.
Originality / Value: The contribution of this research is threefold: the literature has been reviewed to conclude the criteria concerning decisions around ICUs, the concluded criteria filtered through an expert panel which can be relied based on the method, a real application of the steps proposed is presented which allows comparing the accuracy and efficiency of the decisions made in the hospitals.
Knockdown of TUG1 rescues cardiomyocyte hypertrophy through targeting the miR-497/MEF2C axis
Authors: Zhang Guorong , Ni Xinghua 
Published: March 2021

Abstract
The aim of this study was to investigate the detailed role and molecular mechanism of long noncoding RNA (lncRNA) taurine upregulated gene 1 (TUG1) in cardiac hypertrophy. Cardiac hypertrophy was established by transverse abdominal aortic constriction (TAC) in vivo or angiotensin II (Ang II) treatment in vitro. Levels of lncRNA TUG1, miR-497 and myocyte enhancer factor 2C (MEF2C) mRNA were assessed by quantitative reverse transcriptase PCR (qRT-PCR). Western blot assay was performed to determine the expression of MEF2C protein. The endogenous interactions among TUG1, miR-497 and MEF2C were confirmed by dual-luciferase reporter and RNA immunoprecipitation assays. Our data indicated that TUG1 was upregulated and miR-497 was downregulated in the TAC rat model and Ang II-induced cardiomyocytes. TUG1 knockdown or miR-497 overexpression alleviated the hypertrophy induced by Ang II in cardiomyocytes. Moreover, TUG1 acted as a sponge of miR-497, and MEF2C was directly targeted and repressed by miR-497. miR-497 overexpression mediated the protective role of TUG1 knockdown in Ang II-induced cardiomyocyte hypertrophy. MEF2C was a functional target of miR-497 in regulating Ang II-induced cardiomyocyte hypertrophy. In addition, TUG1 regulated MEF2C expression through sponging miR-497. Knockdown of TUG1 rescued Ang II-induced hypertrophy in cardiomyocytes at least partly through targeting the miR-497/MEF2C axis, highlighting a novel promising therapeutic target for cardiac hypertrophy treatment.
Domestication of wild animals may provide a springboard for rapid variation of coronavirus
Authors: Gao Lei 
Published: March 2021

Abstract
Coronaviruses have spread widely among humans and other animals, but not all coronaviruses carried by specific animals can directly infect other kinds of animals. Viruses from most animal hosts need an intermediate host before they can spread widely among humans. Under natural conditions, coronaviruses do not rapidly change from infecting wild animals as intermediate hosts and to spreading widely among humans. The intermediate host might be the animals captured or bred for the purpose of cross-breeding with domesticated species for improvement of the breed. These animals differ from wild animals at the environmental and genetic levels. It is an important direction to study the semi-wild animals domesticated by humans in search for intermediate hosts of viruses widely spread among humans.
MiR-146b-3p protects against AR42J cell injury in cerulein-induced acute pancreatitis model through targeting Anxa2
Authors: Zhang Kunpeng , Zhang Xiaoyu 
Published: March 2021

Abstract

Background
Acute pancreatitis (AP) is a common inflammatory disorder. MicroRNAs play crucial roles in the pathogenesis of AP. In this article, we explored the detailed role and molecular mechanisms of miR-146b-3p in AP progression.

Methods
The rat AR42J cells were treated with cerulein to establish the AP model in vitro. The miR-146b-3p and Annexin A2 (Anxa2) mRNA levels were assessed by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Cell viability and apoptosis were tested using the Cell Counting Kit-8 (CCK-8) and flow cytometry assays, respectively. Caspase-3 activity and the production of interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) were measured by enzyme-linked immunosorbent assay and qRT-PCR. Targeted interaction between miR-146b-3p and Anxa2 was verified by the dual-luciferase reporter and RNA immunoprecipitation assays. Western blot analysis was performed to detect the expression of Anxa2 protein.

Results
Our data revealed that miR-146b-3p was significantly downregulated in AP samples. The enforced expression of miR-146b-3p alleviated cerulein-induced injury in AR42J cells, as evidenced by the promotion in cell viability and the repression in cell apoptosis, as well as the reduction in IL-1β, IL-6, and TNF-α production. Anxa2 was directly targeted and inhibited by miR-146b-3p. Moreover, the alleviative effect of miR-146b-3p overexpression on cerulein-induced AR42J cell injury was mediated by Anxa2.

Conclusions
The current work had led to the identification of miR-146b-3p overexpression that protected against cerulein-induced injury in AR42J cells at least in part by targeting Anxa2, revealing a promising target for AP diagnosis and treatment.
Isogenies on twisted Hessian curves
Authors: Perez Broon Fouazou Lontouo , Dang Thinh , Fouotsa Emmanuel , Moody Dustin 
Published: March 2021

Abstract
Elliptic curves are typically defined by Weierstrass equations. Given a kernel, the well-known Vélu's formula shows how to explicitly write down an isogeny between Weierstrass curves. However, it is not clear how to do the same on other forms of elliptic curves without isomorphisms mapping to and from the Weierstrass form. Previous papers have shown some isogeny formulas for (twisted) Edwards, Huff, and Montgomery forms of elliptic curves. Continuing this line of work, this paper derives explicit formulas for isogenies between elliptic curves in (twisted) Hessian form. In addition, we examine the numbers of operations in the base field to compute the formulas. In comparison with other isogeny formulas, we note that our formulas for twisted Hessian curves have the lowest costs for processing the kernel and our X-affine formula has the lowest cost for processing an input point in affine coordinates.
Mode of delivery of women with Swyer syndrome in a German case series
Authors: Weisshaupt Karen , Henrich Wolfgang , Neymeyer Jörg , Weichert Alexander 
Published: March 2021

Abstract

Objectives
For women with Swyer Syndrome, a 46,XY gonadal dysgenesis, full term pregnancies are possible after oocyte donation. According to literature, mode of delivery is almost always by Caesarean section for various reasons. Medical indications are multiple pregnancies and related complications, preeclampsia, an androgynous shaped pelvis and failed induction of labor. Elective Caesarean sections were performed based on maternal request and medical recommendation.

Methods
Following careful examination and shared decision making, we planned a spontaneous delivery with a patient with Swyer syndrome and tested the different hypotheses regarding anatomical and functional features according to literature. In addition, deliveries of women with Swyer Syndrome were analyzed in a German multicenter case series.

Results
A total of seven women with Swyer syndrome with a total of 10 pregnancies were identified, who later gave birth to twelve live-born children. Seven out of 10 births were performed by elective and non-elective Caesarean section, three births took place vaginally.

Conclusions
In summary, the risk of Caesarean section delivery has increased, but spontaneous delivery can be attempted in the event of inconspicuous findings.
Comparing optical performance of a wide range of perovskite/silicon tandem architectures under real-world conditions
Authors: Singh Manvika , Santbergen Rudi , Syifai Indra , Weeber Arthur , Zeman Miro , Isabella Olindo 
Published: March 2021

Abstract
Since single junction c-Si solar cells are reaching their practical efficiency limit. Perovskite/c-Si tandem solar cells hold the promise of achieving greater than 30% efficiencies. In this regard, optical simulations can deliver guidelines for reducing the parasitic absorption losses and increasing the photocurrent density of the tandem solar cells. In this work, an optical study of 2, 3 and 4 terminal perovskite/c-Si tandem solar cells with c-Si solar bottom cells passivated by high thermal-budget poly-Si, poly-SiOx and poly-SiCx is performed to evaluate their optical performance with respect to the conventional tandem solar cells employing silicon heterojunction bottom cells. The parasitic absorption in these carrier selective passivating contacts has been quantified. It is shown that they enable greater than 20 mA/cm2 matched implied photocurrent density in un-encapsulated 2T tandem architecture along with being compatible with high temperature production processes. For studying the performance of such tandem devices in real-world irradiance conditions and for different locations of the world, the effect of solar spectrum and angle of incidence on their optical performance is studied. Passing from mono-facial to bi-facial tandem solar cells, the photocurrent density in the bottom cell can be increased, requiring again optical optimization. Here, we analyse the effect of albedo, perovskite thickness and band gap as well as geographical location on the optical performance of these bi-facial perovskite/c-Si tandem solar cells. Our optical study shows that bi-facial 2T tandems, that also convert light incident from the rear, require radically thicker perovskite layers to match the additional current from the c-Si bottom cell. For typical perovskite bandgap and albedo values, even doubling the perovskite thickness is not sufficient. In this respect, lower bandgap perovskites are very interesting for application not only in bi-facial 2T tandems but also in related 3T and 4T tandems.