bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Respective Observational Study of Patients on Maintenance Hemodialysis Receiving Parathyroidectomy By Ultrasonic Scalpel
Authors: Gao Dan , Hu Fengqi , Gao Zhao , Yuan Hai 
Published: December 2021

Abstract
Background

Secondary hyperparathyroidism (SHPT) remains a common complication in many patients on maintenance hemodialysis. Kidney Disease Improve Global Outcomes (KDIGO) 2017 guidelines suggest that parathyroidectomy (PTX) should be performed in severe SHPT patients with chronic kidney disease stage 3a-stage 5D. In the present study, we observed the efficacy of ultrasonic scalpel for PTX in SHPT patients on maintenance hemodialysis.
Methods

A total of 74 patients on maintenance hemodialysis who underwent PTX (34 with traditional electrocautery and 40 with an ultrasonic scalpel) were observed between August 2020 and August 2021 at Xiangyang Central Hospital (Hubei University of Arts and Science). Baseline demographic and clinic characteristics were collected pre- and post-PTX. Moreover, the postoperative complications and operation time were assessed between the two groups.
Results

The univariate analysis showed that there was no statistical significance in weight, dialysis duration, serum potassium, serum calcium, alkaline phosphate, triglyceride, and intact parathyroid hormone (iPTH) before and after PTX between the two groups (P>0.05). The operation time in the ultrasonic scalpel group was significantly decreased compared with the traditional electrocautery group (P<0.05). Compared with the traditional electrocautery group, the drainage amount was significantly reduced in the ultrasonic scalpel group, and the number of days with drain and postoperative hospital stay were also remarkably decreased (P<0.05). In addition, a higher incidence of recurrent laryngeal nerve injury occurred in the traditional electrocautery group, while the difference was not significant (P>0.05).
Conclusions

The use of ultrasonic scalpel significantly reduced the operation time and postoperative hospital stay in patients on maintenance hemodialysis undergoing PTX.
Moderation of weight misperception on the associations between obesity indices and cardiovascular disease risk
Authors: Lee Kayoung 
Published: December 2021

Abstract
PurposeTo evaluate whether weight misperception is associated with estimated cardiovascular disease (CVD) risk and whether gender moderates the association between obesity indices and CVD risk.MethodsIn 7836 men and 10299 women aged 40-79 years without CVD history from the 2014–2018 Korea National Health and Nutrition Examination Survey, the risk of 10-year atherosclerotic cardiovascular disease (ASCVD) was calculated using Pooled Cohort Equations. Weight misperception was defined as accurate estimation, overestimation, or underestimation by comparing perceived body shape to actual weight category. Obesity indices were BMI and waist circumference (WC).ResultsIn fully-adjusted models, odds of 10-year ASCVD risk of ≥ 7.5% were lower in men with overestimating weight (odd ratio [95% confidence interval], 0.85 [0.73, 0.99] after adjusting for BMI; 0.79 [0.68, 0.92] after adjusting for WC), but higher in women with underestimating weight (1.44 [1.27, 1.63] after adjusting for BMI; 1.42 [1.26, 1.61] after adjusting for WC) compared to those with accurate weight estimates. Compared to women with accurate weight estimates, the ASCVD risk associated with obesity indices was higher in those who underestimated weight (ß [95% CI], 0.33 [0.23, 0.43] for BMI; 0.16 [0.13, 0.20] for WC), whereas it was lower in those who overestimated weight (-0.15 [-0.28, -0.02] for BMI; -0.07 [-0.11, -0.03] for WC). In men, weight misperception did not moderate the association between obesity indices and the ASCVD risk.ConclusionWeight misperception was associated with CVD risk independently across gender and moderates the association between obesity indices and CVD risk in women.
Arias Intensity Attenuation Relationship in Sichuan-yunnan Region, China
Authors: Liu Ping , Ren Tongjie 
Published: December 2021

Abstract
Arias intensity is an essential ground motion measure correlating with the potential for earthquake-induced landslides. The Sichuan-Yunnan region, which is primarily mountainous, is a high incidence region of earthquake-induced landslides in China. However, there is no available attenuation relationship for this intensity measure due to the backward construction of the stations. In this study, we developed a region-specific Arias intensity attenuation relationship using the China Strong-Motion Networks Center (CSMNC) database which was established in 2008. We recommend this relationship be applied in the Sichuan-Yunnan region for moment magnitudes ranging between 4.2 and 7.9, distances ranging between 0 and 400 km and with Vs30 (the average shear-wave velocity in the upper 30 meters of a soil profile) ranging between 128 and 760 m/s. The current study finds that this relationship’s intra-event, inter-event, and total standard deviations are greater than for other regions. This is likely caused by the complicated seismotectonic activities, nonlinear site effects, error from inferring Vs30, basin effects, etc. However, this relationship has the best performance in fitting and predicting the data from the Sichuan-Yunnan region.
Length of stay in the emergency department and its associated factors among pediatrics patients attending at Wolaita Sodo University Teaching and Referral Hospital, Southern, Ethiopia, 2021.
Authors: Tezera Nega , Negasi Kiberalem Bisete , Tefera Almaze , Getachew Migbaru 
Published: December 2021

Abstract
Background

Pediatrics emergency department length of stay; is the time between emergency department arrival and discharge, admission, or referred. Globally, there is a rising in the need for emergency department visits, which is very high in pediatric patients causing a longer length of stay, which is a global challenge and the bottle neck of hospitals that increase the risk of patients, morbidity, mortality, and reduce satisfaction.
Objective

This study aimed to assess the length of stay and its associated factors in the pediatric emergency department, Wolaita Sodo University Hospital, 2021.
Methods

An institution-based cross-sectional study was conducted from March 15 to May 15/ 2021. A Systematic sampling technique was used to select 422 study participants. Semi-structured interviewer-administered questionnaires and chart reviews were used to collect the data. The data were entered in Epi Data version 4.6 and analyzed with SPSS version 26. Descriptive statistics were applied to describe the prevalence, pediatrics, emergency department length of stay with a 95% confidence interval. Bi-variable and multivariable logistic regression analysis were used to identify the factors associated with length of stay and the significant level was declared at p-value ≤ 0.05 on AOR and 95% confidence interval
Results

The proportion of prolonged pediatric emergency department length of stay was 79.70% (95% CI; 75.7, 83.6). Night time arrival [AOR = 3.19, 95% CI (1.14, 8.98)], weekend arrival [AOR=4.25 95% CI (1.63,11.12], ordered imaging study [AOR = 2.82 95% CI (1.49,5.35)], not got ordered medication in the hospital [AOR = 2.05 95% CI (1.04,4.03)] orange triage category [AOR = 4.01, 95% CI (1.60,10.05)], and duration of pain 13-24 hours[AOR = 0.29, 95% CI (0.89,0.98)], were significantly associated with length of stay
Conclusion

The proportion of prolonged pediatrics emergency department length of stay was high. To decrease the length of stay, it is better to support the investment of resources on solving these benchmarks.
Embeddings from protein language models predict conservation and variant effects
Authors: Marquet Céline , Heinzinger Michael , Olenyi Tobias , Dallago Christian , Bernhofer Michael , Erckert Kyra , Nechaev Dmitrii , Rost Burkhard 
Published: December 2021

Abstract
The emergence of SARS-CoV-2 variants stressed the demand for tools allowing to interpret the effect of single amino acid variants (SAVs) on protein function. While Deep Mutational Scanning (DMS) sets continue to expand our understanding of the mutational landscape of single proteins, the results continue to challenge analyses. Protein Language Models (pLMs) use the latest deep learning (DL) algorithms to leverage growing databases of protein sequences. These methods learn to predict missing or masked amino acids from the context of entire sequence regions. Here, we used pLM representations (embeddings) to predict sequence conservation and SAV effects without multiple sequence alignments (MSAs). Embeddings alone predicted residue conservation almost as accurately from single sequences as ConSeq using MSAs (two-state Matthews Correlation Coefficient – MCC - for ProtT5 embeddings of 0.596±0.006 vs. 0.608±0.006 for ConSeq). Inputting the conservation prediction along with BLOSUM62 substitution scores and pLM mask reconstruction probabilities into a simplistic logistic regression (LR) ensemble for Variant Effect Score Prediction without Alignments (VESPA) predicted SAV effect magnitude without any optimization on DMS data. Comparing predictions for a standard set of 39 DMS experiments to other methods (incl. ESM-1v, DeepSequence, and GEMME) revealed our approach as competitive with the state-of-the-art (SOTA) methods using MSA input. No method outperformed all others, neither consistently nor statistically significantly, independently of the performance measure applied (Spearman and Pearson correlation). Lastly, we investigated binary effect predictions on DMS experiments for four human proteins. Overall, embedding-based methods have become competitive with methods relying on MSAs for SAV effect prediction at a fraction of the costs in computing/energy. Our method predicted SAV effects for the entire human proteome (~20k proteins) within 40 minutes on one Nvidia Quadro RTX 8000. All methods and data sets are freely available for local and online execution through bioembeddings.com, https://github.com/Rostlab/VESPA, and PredictProtein.
Sugar Sweetened Beverages Intake and Risk of Non-Communicable Chronic Diseases in Longitudinal Studies: A Systematic Review and Meta-Analysis with 1.5 Million Individuals
Authors: Santos Leonardo Pozza , Gigante Denise Petrucci , Delpino Felipe Mendes , Maciel Ana Paula , Bielemann Renata Moraes 
Published: December 2021

Abstract
This study aimed to examine longitudinal associations between sugar-sweetened beverages (SSB) intake and type 2 diabetes, obesity, coronary heart disease and stroke in adults. We performed a systematic review and meta-analysis searching for articles in the Pubmed, Lilacs, Web of Science, Cochrane, Embase, and Scopus databases. After screening of titles and abstracts, 27 longitudinal studies were included for the narrative synthesis with all of them presenting medium or high methodological quality. None of the selected studies were from low-income countries and only three were conducted in middle-income countries. Type 2 diabetes was the most investigated disease – outcome in 15 out of 27 studies. Around 80% of the studies enrolled more than 10,000 individuals in the sample, and almost half of them followed the subjects for less than 10 years. A total of 1.5 million individuals were included in the pooled analyses, and results indicated that SSB intake increased the risk of type 2 diabetes (RR = 1.20; 95%C.I. 1.13 – 1.28), obesity (RR = 1.17; 95%C.I. 1.10 – 1.25), coronary heart disease (RR = 1.15; 95%C.I. 1.06 – 1.25), and stroke (RR = 1.10; 95%C.I. 1.01 – 1.19) in adults after adjustment for all potential confounders. Our systematic review and meta-analysis demonstrated that consumption of SSB intake appears to increase the risk non-communicable chronic disease, being the strongest evidence for type 2 diabetes. Actions are needed to be taken to reduce the SSB intake and its consequences worldwide.
The P. aeruginosa Type VI Secretion System Effector Tse5 Forms Ion-Selective Membrane Pores that Disrupt the Membrane Potential of Intoxicated Cells
Authors: González-Magaña Amaia , Altuna Jon , Queralt-Martín María , Largo Eneko , Montánchez Itxaso , Alcaraz Antonio , Albesa-Jové David 
Published: December 2021

Abstract
The Type VI Secretion System (T6SS) of Pseudomonas aeruginosa injects effector proteins into neighbouring competitors and host cells, providing a fitness advantage that allows this opportunistic nosocomial pathogen to persist and prevail during the onset of infections. However, despite the high clinical relevance of P. aeruginosa, the identity and mode of action of most P. aeruginosa T6SS-dependent effectors remain to be discovered. Here, we report the molecular mechanism of Tse5-CT, which is the toxic auto-proteolytic product of the P. aeruginosa T6SS exported effector Tse5. Our results demonstrate Tse5-CT is a pore-forming toxin that can transport ions across the membrane, causing membrane depolarisation and bacterial death. The membrane potential regulates a wide range of essential cellular functions, and therefore membrane depolarisation is an efficient strategy to compete with other microorganisms in polymicrobial environments.
Plataforma Papaya: desafios na implementação de bibliotecas e arquivos digitais
Authors: Silva Roberto Fray da , Hattori Fernando , Agarie Junior Carlos Alberto , Diniz Kollontai Cossich , Gomi Edson Satoshi 
Published: December 2021

A digitalização de acervos é importante tanto como ferramenta para a ampliação do alcance de documentos quanto para a conservação destes. A implementação dos repositórios que receberão esses acervos não é simples e apresenta particularidades que dependem do contexto do acervo e dos seus procedimentos operacionais. A Plataforma Papaya é uma ferramenta para o gerenciamento de acervos digitais. Neste trabalho são apresentadas quatro implementações desta plataforma, duas em acervos de bibliotecas e duas em acervos de arquivos, com seus respectivos requisitos e as decisões de projeto tomadas durante o desenvolvimento.
MACEIÓ EM FOCO: IMPRESSÕES SOBRE IMAGENS E O IMAGINÁRIO DE UMA CIDADE
Authors: Rangel Paula , Melo Hedhyliana , Freitas Alexandra , Machado Maria Luísa , Paula Mayara , Morais Álvaro , Neto Francisco , Araújo Maya , Leite Jéssica , Santos Danielle , Silva Sara , Barbosa Dayanna , Oliveira Roseline 
Published: December 2021

“Terra de gente quase anfíbia”. Assim Gilberto Freyre descreveu Alagoas. “O que tapa o alagadiço” é o significado toponímico da palavra Maceió. Em registros textuais e iconográficos dessa cidade produzidos durante o século XX, a exemplo dos de Lúcio Costa e os de Mário de Andrade, as suas massas de água urbana aparecem com certa recorrência. Tal enfoque desses registros historiográficos motivou a elaboração deste artigo que versa sobre a imagem da cidade de Maceió no contexto da contemporaneidade. Consiste nos resultados da uma investigação, realizada pelos integrantes do Programa de Educação Tutorial do curso de Arquitetura e Urbanismo da Ufal, que trata de um conjunto de fotografias elaboradas por estudantes universitários no ano de 2014 motivadas pelo seguinte questionamento: como você vê Maceió? Cerca de 400 imagens foram analisadas sob um olhar construído a partir da leitura das próprias imagens enquanto representação gráfica de uma forma de perceber o mundo físico. Observando os elementos compositivos e as composições das imagens, assim como indagando sobre seus aspectos subjetivos, notou-se que a maioria das cenas retratadas corresponde a trechos da orla marítima da cidade, onde o mar aparece com relativa força pictórica ocupando grande parte da área do enquadramento fotográfico. Portanto, as imagens recentes da cidade continuam a representar um interesse pela paisagem natural de Maceió, que parece ter sempre “chamado a atenção”, como registrou Mário de Andrade nos anos de 1920, demonstrando uma força paisagística consolidada no e pelo imaginário dos que habitam a cidade até os dias de hoje.
ATELIÊ CA[Ó]TICO: UMA EXPERIÊNCIA DISCIPLINAR PARA DISCUSSÃO DA RELAÇÃO ENTRE SENTIDO E FORMA NA ARQUITETURA
Authors: Cavalcante Eunádia Silva , Do Nascimento José Clewton 
Published: December 2021

Este artigo apresenta uma análise acerca da realização de uma disciplina optativa denominada Ateliê CaÓtico, cuja proposta teve a estruturação definida por uma ementa pautada em uma abordagem projetual com ênfase na observação (relação com o lugar) e nas técnicas de desenho e colagem, como forma de expressão das ideias. Como objetivo geral, buscou estimular nos discentes a prática, no processo de concepção projetual, da percepção dos elementos construídos e sua relação com o entorno, a princípio, sem condicionantes preestabelecidos. Em termos de procedimentos metodológicos foram realizados encontros para apresentação e discussão dos referenciais teórico-conceituais utilizados nas atividades práticas; visitas aos locais selecionados para realização da atividade de experimentação do lugar e, posteriormente, atividades de ateliê tendo em vista a elaboração de propostas arquitetônicas para as referidas áreas, norteadas pela atividade de experimentação do lugar, tendo o croqui e as colagens como veículos de expressão das ideias; apresentação e discussão das propostas. A fala dos alunos, em atividade de avaliação da disciplina, em que se deixa claro a importância do ato de desenhar, planejar em grupo, observar no lugar, conseguir captar a dinâmica do lugar, permanecer no lugar, bem como, a possibilidade da construção de um espaço de debate para o desenvolvimento das propostas, propiciando uma maior liberdade de pensar e se expressar, não se tendo o rigor de etapas pré-estabelecidas, são constatações que, no nosso entender, confirmam o alcance dos objetivos propostos pela disciplina.
ATELIERS DE HISTÓRIA DA ARQUITETURA: ANÁLISE GRÁFICA, DESENHO E MODELOS ANALÍTICOS
Authors: Cotrim Marcio , Tinem Nelci , Vidal Wilnna 
Published: December 2021

Os exercícios e a pesquisa que dão suporte a este ensaio partem do pressuposto de que as diversas formas de análise gráfica podem vir a conformar instrumentos importantes para a interação entre os conhecimentos de teoria, história e projeto de arquitetura e urbanismo. Assim, o propósito dos exercícios, é fazer com que os estudantes se detenham, por meio de produtos gráficos – modelos e desenhos analíticos – na observação criteriosa do edifício arquitetônico e comuniquem visualmente o resultado desse esforço. Como propõe Eisenman trata-se de proceder a uma “leitura em detalhe” da obra e assim revelar particularidades subjacentes ao projeto que, de outro modo, passariam despercebidas.
RIBEIRA EM FOCO: CONCURSO BID URBANLAB BRASIL/NATAL - PERSPECTIVAS UNIVERSITÁRIAS
Authors: Silva Maria Floresia Pessoa de Souza , Santos Karitana de Souza , Cobbe André Luís 
Published: December 2021

O BID UrbanLab é um concurso universitário destinado a buscar soluções criativas e ideias inovadoras para os problemas urbanos da América Latina e do Caribe (ALC), em parceria com estudantes, professores universitários e jovens profissionais. Seu objetivo é atuar como incubadora de jovens talentos em temas urbanísticos, a partir de uma rede de trabalho com universidades, promover um espaço participativo para o questionamento dos paradigmas atuais, que orientam as práticas em projetos urbanísticos, bem como, introduzir no mercado de trabalho jovens que se interessam em atuar nesta área.
O concurso BID UrbanLab Brasil 1ª Edição teve um amplo alcance, com a participação de quarenta equipes, de trinta e uma universidades, originárias de dezesseis cidades do país. O destaque da Universidade Federal do Rio Grande do Norte (UFRN) foi muito importante classificando-se com seis projetos, dentre os vinte projetos semifinalistas, quais sejam: Ribeira Conectada; Cidade Nascente; (+) Ribeira; Olhos da Ribeira; Trilhos da Ribeira: Marcas do Passado Caminhos para o Futuro; e Ribeira: Foz da Cidade. Ao final, foram laureadas duas equipes da UFRN, a equipe Ribeira: Foz da Cidade, com menção honrosa e a equipe Olhos da Ribeira, vencedora do concurso.
TRILHOS DA RIBEIRA: MARCAS DO PASSADO, CAMINHOS PARA O FUTURO
Authors: Brasil Amiria Bezerra , Andrade Caio , Viana Daniel Lucas , Gomes Débora , Lopes Flávia , Gomes Isadora 
Published: December 2021

Esta proposta tem como objetivo principal a regeneração da importância do bairro da Ribeira na cidade de Natal/RN, através do reconhecimento de sua história, valor patrimonial e identidade cultural. O projeto está pautado por soluções sustentáveis, de baixo custo, alinhadas com a realidade local e que possam colaborar com o resgate da vitalidade urbana, atraindo um maior número de pessoas para utilizar o local, ressaltando sua importância cultural e econômica para o cenário da cidade. O conceito principal faz analogia aos trilhos do trem, elemento que permeia a poligonal de intervenção e ajuda a remontar um cenário que em tempos mais antigos foi o símbolo do desenvolvimento econômico, cultural e intelectual da área e da cidade. Para o desenvolvimento da proposta, o grupo elencou 18 ações necessárias, dentre as quais se destacam 03 grandes eixos de intervenção: (i) Intervenção na Avenida Tavares de Lira – construção no local objetivando valorizar o visual paisagístico de modo que possa haver um resgate e consolidação da atividade comercial e cultural na área; (ii) Um Novo Terminal de Ônibus Urbano – construção de um novo terminal de ônibus para a melhoria da mobilidade, mais conforto e comodidade ao usuário do transporte público local; (iii) A Renovação das Áreas Públicas – reforma da infraestrutura de ruas, calçadas e passeios públicos para melhorar a caminhabilidade dos pedestres e mobilidade de veículos no local. A equipe buscou trabalhar com diferentes escalas de projeto, articulando intervenções de ordem local que pudessem ter desdobramentos no bairro e na cidade.
In vitro Anti-hemolytic Effect, in vivo Anti-inflammatory and in vitro
Anti-oxidant Activity of Anchusa azurea Mill
Authors: Boussoualim Naouel , Trabsa Hayat , Krache Imane , Ouhida Soraya , Arrar Lekhmici , Baghiani Abderrahmane 
Published: December 2021

Background:
Anchusa azurea Mill. (AA) is a medicinal plant largely used traditionally
in folk medicine in Algeria; it is locally named hamham. It is effective in the treatment of various
diseases.

Objectives:
The aim of the present study is to determine the antioxidant, anti-inflammatory, and anti-
hemolytic effects of phenolic fractions from Anchusa azurea Mill.

Methods:
In this study, various extracts from Anchusa azurea Mill. (AA) using solvents with increasing
polarity were prepared. The quantification of polyphenols and flavonoids was determined.
The anti-radical activity of the different extracts was evaluated using DPPH and by measuring the
inhibition of the oxidative degradation of β-carotene. The In-vitro antihemolytic effect of the plant
extracts is determined (CrE, ChE, AcE, and AqE). For each extract, four concentrations were tested:
10.59, 21.18, 42.37, 84.74 μg/ml. Vitamin C is used as a standard. The free-radical attack was
measured by measuring the HT50 (Half-Hemolysis Time). The anti-inflammatory effect using PMA
on mice of the methanolic extract (CrE) was evaluated.

Results:
The quantification of polyphenols and flavonoids showed that ethyl acetate extract (AcE)
contains a higher amount of polyphenols. However, chloroform extract (ChE) presents a higher
amount of flavonoids. AcE showed an important scavenging activity using the DPPH radical
(IC50= 68.35 μg/ml). The results showed that AcE also exhibited asignificant inhibition effect on
the oxidation of β-carotene/linoleic acid (84.33 %). All extracts increased the HT50 values (Half-Hemolysis
Time) in a dose-dependent manner. The three highest concentrations (21.18, 42.37, and
84.74 μg / ml) of ChE caused a very significant delay (p ≤ 0.001) of hemolysis compared to the
negative control and the positive control “VIT C”. The anti-inflammatory effect of using PMA on
mice showed that the methanolic extract (CrE) of AA reduced the weight of the ear edema.

Conclusions:
This plant has a strong pharmacological power, which supports its traditional medicinal
use.