bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D Cohesive Finite Element Minimum Invasive Surgery Simulation Based on Kelvin Voigt Model
Authors: Jiang Yonghang , Song Qinghua , Luo Xichun 
Published: June 2021

Abstract
Minimum Invasive Surgery is an important means of cytopathological examination. At present, there are few researches on three dimensional (3D) puncture simulation model base on suitable constitutive model, so a reasonable three dimensional puncture simulation model can reveal the internal deformation state of the tissue at the micro level. In this paper, a new viscoelastic constitutive equation suitable for muscle tissue and a method to define the fracture characteristics of muscle tissue material in the simulation process are proposed. The fracture of muscle tissue in contact with puncture needle is simulated by using the cohesive zone model, and a 3D puncture finite element model is established to analyze the deformation of muscle tissue. The stress nephogram and reaction force under different parameters were compared and analyzed to study the deformation of biological soft tissue, so as to guide the actual operation process and reduce pain.
Equol Production Status is An Effective Predictor of Nonalcoholic Steatohepatitis in Women
Authors: Akahane Takemi , Kaya Daisuke , Noguchi Ryuichi , Kaji Kosuke , Miyakawa Haruna , Fujinaga Yukihisa , Tsuji Yuki , Takaya Hiroaki , Sawada Yasuhiko , Furukawa Masanori , Kitagawa Koh , Ozutsumi Takahiro , Kawaratani Hideto , Moriya Kei , Namisaki Tadashi , Yoshiji Hitoshi 
Published: June 2021

Abstract
Equol is a metabolite of daidzein, a major soybean isoflavone with estrogenic and antioxidant activities. As the production of equol depends on the presence of certain members of the intestinal microflora, not all individuals can produce equol. The incidence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) increases in menopausal women, and estrogen is associated with the progression of NAFLD/NASH. Therefore, the status of equol production might also be related to the pathogenesis of NAFLD/NASH in women. We, thus, examined the relationship between NASH histological features and equol production. Thirty-eight NAFLD patients who underwent liver biopsy were included in this study. In women, the degree of fibrosis and ballooning in nonproducers was significantly higher than that in producers. The percentage of nonproducers with NAFLD activity score (NAS) ≥5 was significantly higher than that of producers. None of the histological features were significantly different between nonproducers and producers in men. Decision tree analysis identified the predictors of NAS ≥5 in women. The status of equol production was the strongest predictor, followed by fasting glucose. Equol can be noninvasively detected in urine, suggesting its application as a screening test for predicting the diagnosis and progression of NASH in women.
Fine Mapping and Identification of the Candidate Gene BFS for Fruit Shape in Wax Gourd (Benincasa Hispida)
Authors: Cheng Zhikui , Liu Zhengguo , Xu Yuanchao , Ma Lianlian , Chen Jieying , Gou Jiquan , Su Liwen , Wu Wenting , Chen Yong , Yu Wenjin , Wang Peng 
Published: June 2021

Abstract
Fruit shape is an important agronomic trait in wax gourds [Benincasa hispida (Thunb) Cogn.]. However, the candidate genes for this important trait, and their genetic mechanisms, remain unknown. In this study, we identified a candidate gene for fruit shape in wax gourds using a next-generation sequencing-based bulked segregant analysis in F2 populations derived from a cross between GX-71 (long cylindrical fruit, FSI = 4.56) and MY-1 (round fruit, FSI = 1.06) genotypes. According to bulked segregant analysis, the candidate gene is located in the 17.18 Mb region on chromosome 2, and the kompetitive allele specific polymerase chain reaction (KASP) marker was used to reduce it to the 19.6 Kb region. There is only one gene in the corresponding region of the reference genome, Bch02G016830 (designated BFS). We sequenced BFS in six wax gourd varieties with different fruit shapes. Sequence analysis showed that there were two non-synonymous mutations in the spherical wax gourd and one non-synonymous mutation in the cylindrical wax gourd. Quantitative real‑time polymerase chain reaction (qRT-PCR) analysis showed that the expression of BFS in round fruits was significantly higher than in long cylindrical fruits at the ovary formation stage. Therefore, BFS is a candidate gene for determination of the fruit shape of wax gourds. The predicted protein encoded by the BFS gene belongs to the IQD protein family, which have the structural characteristics of scaffold proteins and coordinate Ca2+ CaM signaling from the membrane to the nucleus. The BFS gene can assist with the breeding of new varieties that possess ideal fruit shapes.
Discrete Bright-dark Soliton Interaction Dynamic Behaviors for Nonautonomous 2+1-Dimensional Soliton Equation
Authors: Li Li , yu fajun 
Published: June 2021

Abstract
The non-autonomous discrete bright-dark soliton solutions(NDBDSSs) of the 2+1-dimensional Ablowitz-Ladik(AL) equation are derived. We analyze the dynamic behaviors and interactions of the obtained 2+1-dimensional NDBDSSs. In this paper, we present two kinds of different methods to control the 2+1-dimensional NDBDSSs. In first method, we can only control the wave propagations through the spatial part, since the time function has not effect in the phase part. In second method, we can control the wave propagations through both the spatial and temporal parts. The different propagation phenomena can also be produced through two kinds of managements. We obtain the novel "л"-shape non-autonomous discrete bright soliton solution(NDBSS), the novel "λ"-shape non-autonomous discrete dark soliton solution(NDDSS) and their interaction behaviors. The novel behaviors are considered analytically, which can be applied to the electrical and optical fields.
Smoking Related Attention Alteration in Chronic Obstructive Pulmonary Disease-Smoking Comorbidity
Authors: Zeng Feiyan , Hong Wei , Zha Rujing , Li Ying , Liu Ying , Liu Hao , Liu Mengqiu , Liu Mei , Xu Fei , Hu Daiju , Song Hongwen , Yu Yongqiang , Zhang Xiaochu 
Published: June 2021

Abstract
Chronic obstructive pulmonary disease is a respiratory disease that causes a wide range of cognitive impairments. Although chronic obstructive pulmonary disease-smoking comorbidity is common, the relationship between smoking and cognitive function in chronic obstructive pulmonary disease-smoking comorbidity remains unclear. In this study, we recruited 85 participants, including 42 patients with Chronic obstructive pulmonary disease(20 smokers and 22 non-smokers) and 43 healthy participants(22 smokers and 21 non-smokers). And we used the Montreal Cognitive Assessment scale and resting-state functional magnetic resonance imaging to explore effects of smoking on attention in patients with chronic obstructive pulmonary disease. Behavioral analysis revealed that smokers had a shorter course of chronic obstructive pulmonary disease and showed a worse attention performance in chronic obstructive pulmonary disease-smoking comorbidity compared to non-smokers. Resting-state functional magnetic resonance imaging analysis revealed that smokers showed lower regional homogeneity value of the fusiform gyrus in chronic obstructive pulmonary disease-smoking comorbidity than non-smokers. Importantly, the regional homogeneity of the fusiform gyrus was positively associated with attention and mediates the effect of smoking on attention in chronic obstructive pulmonary disease. In summary, our study provides behavioral and neurobiological evidence supporting the positive effect of smoking on attention in chronic obstructive pulmonary disease. This may be helpful for understanding and treating chronic obstructive pulmonary disease and even other diseases comorbid with smoking.
Terahertz Conductivity of Silver Nanowire Layers
Authors: Przewloka Aleksandra , Smirnov Serguei , Nefedova Irina , Krajewska Aleksandra , Nefedov Igor , Demchenko Petr , Zykov Dmitry , Chebotarev Valentin , But Dmytro , Stelmaszczyk Kamil , Lisauskas Alvydas , Oberhammer Joachim , Khodzitsky Mikhail , Knap Wojciech , Lioubtchenko Dmitri 
Published: June 2021

Abstract
We present the study of the influence of different thin silver nanowire layers on electrical and optical properties in the Terahertz (THz) frequency range. We demonstrate that the absorbance, transmittance and reflectance of the metal nanowire layers in the frequency range of 0.2~THz to 1.2~THz is non-monotonic and depends on the nanowire dimensions and density. We present and validate also a theoretical approach describing well the experimental results and allowing to model the THz response as function the nanowire layer structure. Our results pave the way toward the application of silver nanowires as a perspective material for transparent and conductive coatings, and printable antennas operating in the terahertz range – significant for future wireless communication devices.
Trend and factors associated with iron supplementation during pregnancy among women who had pregnancy in the preceding five years of the 2005, 2011 and 2016 EDHS: Multivariate decomposition analysis
Authors: Tareke Abiyu Abadi , Bekele Ermias 
Published: June 2021

Abstract
Introduction: Study estimated in 2019 iron deficiency related anemia accounts 1.89% and 1.07% of total disability adjusted life years (DALYS) to reproductive age women globally and sub saran Africa respectively. Anemia at the time of pregnancy may cause small sized baby, preterm birth, and perinatal, neonatal and maternal mortality. Iron and folic acid supplementation during pregnancy will minimize the risk of iron deficiency and risk of anemia.Methods: for this time series analysis, dataset of 2005, 2011 and 2016 Ethiopian demographic health surveys was used. A total weighted sample of 7234 in 2005, 7786 in 2011 and 7543 in 2016 are encompassed in this study. The Logit based Multivariate decomposition analysis for non-linear response outcome was calibrated to detect the factors contributed to the change in iron supplementation between 2005 and 2016 study period. The Logit based multivariate decomposition analysis utilizes the output from the logistic regression model to assign the observed change in iron supplementation over time into two components. Stata version 16.0 was used to analysis the data.Results: proportion of iron supplementation during pregnancy increased by more than a third (32%) between the period of 2005 and 2016. From the output of multivariate decomposition regression, major of the change in iron supplementation was due to change in coefficients. Women’s age, working s status and region of living (all except Dire Dawa) were variables as sources of change in iron supplementation under the category of change in coefficients. Additionally, age, region, wealth status, employment status/working status, ANC follow up to the last pregnancy and media exposure were variables attributable to the change of iron supplementation during pregnancy under the category of endowment. Conclusion: rate of iron supplementation at the time of pregnancy increased dramatically over the last decade in Ethiopia. Change in the proportion of women aged ≥ 35 years, population of each region, wealth status (poorer, middle & richer), working women, ANC follow up and media exposed as well as change in behavior of women aged ≥ 35 years, employed women and region of living were sources of change for iron supplementation between 2005 and 2016 period. Keywords: iron supplementation, trends, EDHS, Ethiopia, multivariate decomposition analysis
ReString – Automating Functional Enrichment Retrieval and Results Aggregation
Authors: Manzini Stefano , Busnelli Marco , Colombo Alice , Franchi Elsa , Chiesa Giulia 
Published: June 2021

Abstract
Functional enrichment analysis is an analytical method to extract biological insights from gene expression data, popularized by the ever-growing application of high-throughput techniques. Typically, expression profiles are generated for hundreds to thousands of genes/proteins from samples belonging to two experimental groups, and after ad-hoc statistical tests, researchers are left with lists of statistically significant entities, possibly lacking any unifying biological theme. Functional enrichment tackles the problem of putting overall gene expression changes into a broader biological context, based on pre-existing knowledge bases of reference: database collections of known expression regulation, relationships and molecular interactions. STRING is among the most popular tools, providing both protein-protein interaction networks and functional enrichment analysis for any given set of identifiers. For complex experimental designs, manually retrieving, interpreting, analyzing and abridging functional enrichment results is a daunting task, usually performed by hand by the average wet-biology researcher. We have developed reString, a cross-platform software that seamlessly retrieves from STRING functional enrichments from multiple user-supplied gene sets, with just a few clicks, without any need for specific bioinformatics skills. Further, it aggregates all findings into human-readable table summaries, with a built-in feature to easily produce user-customizable publication-grade clustermaps. Herein, we outline a complete reString protocol, showcasing its features on a real use-case.
Malignant Transformation Of Fibrous Dysplasia In Combination With Bone Cyst: A Case Report.
Authors: Xu Meitao , Wang Jiajia , Zhang Xi , wang xuquan 
Published: June 2021

Abstract
Background: Fibrous dysplasia and Simple bone cyst are all common benign lesions. A case of osteosarcoma developing from fibrous dysplasia in combination with unicameral bone cyst will be discussed. The radiologic, histologic characteristics and clinical prognostic of the patient will be described. As far as we know, this is the first case report of malignant transformation secondary to fibrous dysplasia in combination with unicameral bone cyst, which is extremely rare and worthy of clinical attention or vigilance. Case presentation: This study describes a case of a 20-years-old male who suffered a 7-years history of intermittent pain in his right proximal tibia, obvious after activity and progressively worsening. Clinical symptoms and imaging examination were consistent with the characteristics of benign primary bone tumor. He underwent a successful curettage operation. Pathological diagnosis was fibrous dysplasia in combination with unicameral bone cyst. After the curettage surgery, the pain in his right knee quickly disappeared and function activities returned to normal during a regular follow-up postoperative. However, He was diagnosed with a recurrence of fibrous dysplasia in combination with unicameral bone cyst and osteosarcoma malignant transformation by chief complaint symptoms of pain and swelling in the right proximal tibia, adequate imaging examination, and pathological diagnosis at 2 years follow-up. Then the patient undergo a limb salvage with tumor prosthesis reconstruction of the right knee. Unfortunately, multiple and unresectable lymph nodes distant metastases happened even with two weeks localized inguinal radiotherapy treatment and one course of neoadjuvant chemotherapy monthly. He eventually received cancer hospice care and died eight months after the diagnosis as malignant transformation and systemic multiple organ metastasis.Conclusions: Although malignant transformation of fibrous dysplasia in combination with unicameral bone cyst is very rare, patients with this disease should be monitored and received lifelong follow-up to obtain early detection, diagnosis and treatment to maximize the efficacy of treatment and survival time. The histological and immunohistochemical findings is very important but not enough. Further research is required to clarify the pathogenesis and prevent malignant transformation.
Case Report: A Rare Huge Giant Cell Tumor of the Proximal Tibia
Authors: Zheng Bingxin , Sun Lingling , Qu Guojian , Ren Chongmin , Yan Peng , Yue Bin 
Published: June 2021

Abstract
Background: Giant cell tumor of bone is a common primary borderline bone tumor, while giant cell tumor of bone in the extremities are generally not very large. Because most tumors have already been controlled by some treatments at the time of pain or finding the tumor. Huge giant cell tumors of bone in the limbs are very rare.Case presentation: We describe a case of a huge giant cell tumor of the proximal tibia with 6-year history and not receiving any treatment. It is not until the rupture and bleeding appeared that the patient is referred to the doctor, and amputation is the only treatment.Conclusions: This report suggests that although giant cell tumor of bone is a borderline tumor, early diagnosis and treatment are essential in order to improve patient prognosis.
A Case Report of Multifocal PEComa Affecting the Pancreas and Liver and a Literature Review
Authors: Guan Jian , Shen Guihua , Huang Wenting 
Published: June 2021

Abstract
Background: Perivascular epithelioid cell tumor (PEComa) is a rare tumor derived from soft tissues and organs. Its morphology includes several types such as angiomyolipoma, lymphangiomyomatosis and pulmonary clear-cell “sugar” tumor with similar immunophenotype. Multifocal PEComa is a rarer lesion, which would cause confusion in imaging examination and clinical management. We reported a case of multifocal angiomyolipoma in pancreas and liver. At the same time, we reviewed the literature to explore the clinicopathological characteristics and possible pathogenesis of multifocal PEComa.Case presentation: A 28-year-old woman presented with a lesion in the head of the pancreas and liver 5/6 segment respectively, initially suspected of pancreatic tumor with liver metastasis. In the liver mass resection and pancreatic mass biopsy, it was found that the two lesions had similar pathological morphology. The tumor cells were mainly epithelioid and spindle cells arranged in nests pattern and partially radially distributed around blood vessels. The tumors had no malignant manifestations in morphology. Immunohistochemical assay showed that the tumor cells expressed melanocytic and smooth muscle markers. A diagnosis of pancreatic and liver angiomyolipoma was rendered.Conclusion: Based on the case we reported here and the other 12 cases we reviewed for the study, multifocal PEComa with no indications of malignancy based on morphology is biologically benign and has a good prognosis. The lesion may be caused by the blood dissemination of tumor cells rather than metastasis. Radical treatment should not be used in clinical management. In addition, follow-up for PEComa would be long-term, because a second PEComa lesion may appear many years later for the “benign” dissemination of tumor cells.
A pre-pandemic COVID-19 assessment of the costs of prevention and control interventions for healthcare associated infections in medical and surgical units in Québec
Authors: Tchouaket Eric , Robins Stephanie , Boivin Sandra , Sia Drissa , Kilpatrick Kelley , Dubreuil Bruno , Larouche Catherine , Parisien Natasha , Létourneau Josiane 
Published: June 2021

Abstract
Background

Healthcare-associated infections (HCAIs) present a major public health problem that significantly affects patients, health care providers and the entire healthcare system. Infection prevention and control programs limit HCAIs and are an indispensable component of patient and healthcare worker safety. The clinical best practices (CBPs) of handwashing, screening, hygiene and sanitation of surfaces and equipment, and basic and additional precautions are keystones of infection prevention and control (IPC). Systematic reviews of IPC economic evaluations report the lack of rigorous empirical evidence demonstrating the cost-benefit of IPC program in general, and point to the lack of assessment of the value of investing in CBPs more specifically.
Objective

This study aims to assess overall costs associated with each of the four CBPs.
Methods

Across two Quebec hospitals, 48 healthcare workers were observed for two hours each shift, for two consecutive weeks. A modified time-driven activity-based costing framework method was used to capture all human resources (time) and materials required (e.g. masks, cloths, disinfectants) for each clinical best practice. Using a hospital perspective with a time horizon of one year, median costs per CBP per hour, as well as the cost per action, were calculated and reported in 2018 Canadian dollars. Sensitivity analyses were performed.
Results

A total of 1831 actions were recorded. The median cost of hand hygiene (N = 867) was 19.6 cents per action. For cleaning and disinfection of surfaces (N = 102), the cost was 21.4 cents per action, while cleaning of small equipment (N = 85) was 25.3 cents per action. Additional precautions median cost was $4.13 per action. The donning or removing or personal protective equipment (N = 720) cost was 75.9 cents per action. Finally, the total median costs for the five categories of clinical best practiced assessed were 27.2 cents per action.
Conclusion

The costs of clinical best practices were low, from 20 cents to $4.13 per action. This study provides evidence based arguments with which to support the allocation of resources to infection prevention and control practices that directly affect the safety of patients, healthcare workers and the public. Further research of costing clinical best care practices is warranted.
Looking into the flora of Dutch Brazil: botanical identifications of seventeenth century plant illustrations in the Libri Picturati
Authors: Alcántara-Rodríguez Mireia , Françozo Mariana , Andel Tinde Van 
Published: June 2021

Abstract
The Libri Picturati includes a collection of plant illustrations from seventeenth century Dutch Brazil that is kept in the Jagiellonian library in Krakow since World War II. While many studies focused on the artistic details of these images, we identified the flora depicted. We used contemporary textual sources (e.g., Historia Naturalis Brasiliae), monographs and taxonomist’ assessments. We checked origin, life form, domestication and conservation status and the plant parts that are represented. We identified 198 taxa, consisting mostly of wild, native rainforest trees and 35 introduced species. Fertile branches are the most represented, although some loose dry fruits and sterile material were also painted, which sheds light into the collection methods by naturalists in Dutch Brazil. Several species are no longer abundant or have become invasive due to anthropogenic influences since colonialism. Through this botanical iconography, we traced the first records of the sunflower and the Ethiopian pepper in Brazil, as well as the dispersion and assimilation of the flora encountered in the colony by Indigenous, African and European peoples. We emphasized the relevance of combining visual and textual sources when studying natural history collections and we highlighted how digitalization makes these artistic and scientific collections more accessible.