bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ways of medicinal prevention and treatment of doxorubicin-induced cardiomyopathy in oncological patients
Authors: Moroz V.A. , Al-Hadrawi R.A. , Andrieieva O.O. , Timchenko Yu.V. , Semenov A.M. 
Published: April 2021

The high incidence of malignant tumors is currently supported by the general ageing of the world population and unfavorable environmental factors. In 2018, 18.1 million new cases of cancer and 9.6 million deaths from them were registered in the world. At the same time, a significant increase in the life expectancy of these patients after the treatment noted over the past 20 years highlights the problem of side effects of the anticancer therapy. One of the most serious side effects is the development of doxorubicin-induced cardiomyopathy (DRIC). In all three distinct clinical forms (acute, early and late) DRIC can develop in 58 % of patients after using anticancer treatment regimens with the inclusion of doxorubicin. The review provides a detailed analysis of medicinal treatment regimens and preparations (ACE inhibitors, beta-blockers, statins, etc.) currently used, and evaluates their effectiveness and expected results. Currently, several therapeutic strategies have been proposed for the prevention and treatment of DRIC, each of them has certain positive results. At the same time, some therapeutic methods used in the clinic have some disadvantages.
Conclusions. The limitations of the results of DRIC prevention achieved by the existing therapeutic regimens, as well as the possibilities for their prediction, have been stated. The need for further research to improve the effectiveness of medicinal prevention and treatment of DRIC is emphasized.
Development of methods for analysis of the amount of flavonoids and their stability study in the combined dental gel
Authors: Maslii Yu. , Materiienko A. , Ruban O. , Bezruk I. , Ivanauskas L. 
Published: April 2021

An important aspect in the pharmaceutical development of dental medicines is to provide them with a prolonged therapeutic effect while reducing the side effects of drug substances and the possibility of long-term use. This can be achieved by using active components of plant origin.
Aim. To develop methods for analyzing biologically active substances in the composition of a new combined dental gel.
Materials and methods. The study object was a dental gel containing “Phytodent” complex tincture (PJSC “CPP Chervona zirka”, Ukraine). Based on the analysis of the composition of the tincture it was proposed to carry out standardization by the amount of biologically active substances, namely flavonoids. Identification was carried out by TLC, while the quantitative determination by absorption spectrophotometry, the ultraviolet and visible method by the reaction with aluminum chloride using the standard method calculated with reference to rutin and the absorbance measurement at 406 nm.
Results and discussion. As a result of the research, the methods for the analysis of flavonoids in the composition of the new combined gel have been developed. The spectrophotometric method developed is characterized by specificity, accuracy, precision and linearity with r = 0.9998. One of the important issues when using components of plant origin is their stability both during preparation and storage. Using the method developed the stability of flavonoids has been studied depending on pH changes of the carbomer-based dental gel.
Conclusions. It has been determined that the methods developed are easily reproducible and allow to identifying and quantifying flavonoids in the dental gel. It has been found that a stable content of flavonoids is characteristic of the carbomer-based gel neutralized to pH values from 5.0 to 6.0.
Potentiometric determination of organic acids in the medicinal plant raw material
Authors: Oproshanska T. , Khvorost O. 
Published: April 2021

Aim. To analyze the results of the quantitative content of the amount of organic acids in rhizomes with roots of Rumex confertus, rhizomes with roots of Sanguisorba officinalis, roots of Rosa majalis and roots of Rosa canina, roots of Arctium minus and roots of Arctium tomentosum, herb of Bidens tripartite by the potentiometric method, which is available in the monograph “Hibiscus” in the SPhU 2.0.
Materials and methods. The study subjects were batches of rhizomes with roots of Rumex confertus, rhizomes with roots of Sanguisorba officinalis, roots of Rosa majalis and roots of Rosa canina, roots of Arctium minus and roots of Arctium tomentosum, herb of Bidens tripartite. The quantitative content of the amount of organic acids was determined by the potentiometric method from the monograph “Hibiscus” SPhU 2.0 using a HI 2550 potentiometer of the “HANNA instruments” company (Germany).
Results and discussion. The highest content of the amount of organic acids, among the study subjects was in roots of Arctium minus (from 1.02 ± 0.04 % to 1.05 ± 0.04 %). At the same time, in roots of Arctium tomentosum this amount was almost 3 times lower (from 0.36 ± 0.01 % to 0.37 ± 0.01 %). In the batches of roots of Rosa majalis the content of this group of compounds was almost 2 times higher than in roots of Rosa canina. In rhizomes with roots of Rumex confertus and rhizomes with roots of Sanguisorba officinalis the content of the amount of organic acids differed insignificantly. In herb of Bidens tripartite the content of this group of compounds was 0.78 ± 0.03 – 0.79 ± 0.03 %. In different batches of one type of the raw material the quantitative content of the amount of organic acids varied slightly.
Conclusions. For the first time, the quantitative content of the amount of organic acids has been determined in the batches of rhizomes with roots of Rumex confertus, rhizomes with roots of Sanguisorba officinalis, roots of Rosa majalis and roots of Rosa canina, roots of Arctium minus and roots of Arctium tomentosum, herb of Bidens tripartite using the potentiometric method which is available in the monograph “Hibiscus” in the SPhU 2.0. It has been found that the highest content of the amount of organic acids is observed in roots of Arctium minus (not less than 1.02 %) and herb of Bidens tripartite (not less than 0.78 %). The results obtained will be used in further research when creating new herbal medicines with the anti-inflammatory and antimicrobial activity.
De periodontitis agresiva a periodontitis: modificaciones en su clasificación y tratamiento a través del reporte de caso
Authors: Rustrián-Campillo Michelle , Russell-Hernández Miguel Hazael , García-Rivera Miguel Eric , Nachón-García María Gabriela 
Published: April 2021

Introducción: En la Clasificación de las Enfermedades y Afecciones Periodontales y Periimplantarias de 2018, la periodontitis agresiva (PA), se considera como enfermedad periodontal estadio IV, grado C, patrón incisivo molar. Consiste en una patología bucal que ocurre en individuos aparentemente sanos, con periodontitis, rápida pérdida de inserción, destrucción ósea y agregación familiar. A lo largo de décadas esta enfermedad ha sufrido cambios en su definición y clasificación. Objetivo: Describir por medio del caso clínico las características y tratamiento de la periodontitis agresiva en la clasificación periodontal más reciente. Reporte de caso: hombre de 49 años, diagnosticado con periodontitis agresiva generalizada (PAG), con base en los hallazgos clínicos y radiográficos. Se realizó un tratamiento integral, con seguimiento de tres años, observando recidiva de la enfermedad. Conclusión: la implementación del uso de indicadores séricos y exámenes microbiológicos podría mejorar la clasificación actual y facilitar el diagnóstico y manejo del paciente. Palabras clave: Periodontitis agresiva; enfermedad periodontal estadio IV-grado C; clasificación periodontal; diagnóstico periodontal. From aggressive periodontitis to periodontitis: modifications in its classification and treatment through the case reportIntroduction: In the Classification of Periodontal and Peri-implant Diseases and Conditions of 2018, aggressive periodontitis (AP) is considered stage IV, grade C periodontal disease, molar incisor pattern. It consists of an oral pathology that occurs in apparently healthy individuals, with periodontitis, the rapid loss of attachment, bone destruction, and familial aggregation. Over the decades, this disease has changed its definition and classification. Objective: To describe aggressive periodontitis's characteristics and treatment in the most recent periodontal through the clinical case category. Case report: 49-year-old man, diagnosed with generalized aggressive periodontitis (PAG), based on clinical and radiographic findings. Comprehensive treatment was carried out, with a three-year follow-up, observing recurrence of the disease. Conclusion: The implementation of serum indicators and microbiological examinations could improve the current classification and facilitate the patient's diagnosis and management.Keywords: aggressive periodontitis, stage IV-grade C periodontal disease, periodontal classification, periodontal diagnosis.
Gestoras culturales en tiempos de pandemia. Educación feminista contra las violencias
Authors: Casados González Estela , Becerra Zavala María de Lourdes 
Published: April 2021

El papel de las gestoras culturales ha sido decisivo para llevar a la escena social temáticas que interesan a las mujeres y a la sociedad en su conjunto. Si bien la pandemia desatada por el SARS-CoV-2 ha planteado retos al quehacer cultural, diversas agrupaciones lideradas por mujeres encontraron un impulso inusitado en el incremento de la violencia de género que tuvo lugar en el país en el primer semestre de 2020. En este marco, los Observatorios de Políticas Culturales y Universitario de Violencias contra las Mujeres realizamos una aproximación analítica a la intensa actividad cultural que se generó en el estado de Veracruz, a propósito de eventos organizados por gestoras de Recultivar México, los cuales tenían como objetivo recuperar y fortalecer procesos que, desde la educación feminista fomentando los derechos culturales y humanos de las mujeres, pudiesen dar respuesta a la violencia feminicida agravada por el confinamiento. Women as cultural management during pandemic times. Feminist education against violenceWomen's role as cultural management has been critical in bringing up social issues relevant to women, as well as to society in its whole. While the pandemic brought upon by SARS-CoV-2 has raised challenges to cultural endeavours, many organizations led by women have found an unusual impulse in the increase of gender violence in the country during the first semester of 2020. In this panorama, as both the Observatory of Cultural Policies and the Academic Observatory of Violence against Women, we have taken upon ourselves to create an analytical approach to the significant cultural activity in the state of Veracruz which arises from different events organized by women from Recultivar México (Recultivating Mexico), whose objective is reclaiming and strenghthening processes that, within a feminist pedagogical approach which reinforces cultural and human rights of women, may present a proper response to femicide-related violence aggravated by social confinement.Keywords: cultural management, feminism, gender, violence and education.
Cultura digitalizada, buscando estrategias durante la emergencia sanitaria por COVID-19
Authors: Becerra Zavala María De Lourdes , Méndez Delgado Julia Josefa , Hernández Rivera Néstor Igor , Andrade Sosa Perla Génesis , Lozada Andrade Zazil Elideth 
Published: April 2021

En México ha pasado un año en aislamiento social en casa debido a la pandemia por COVID-19. Surgieron encuestas y análisis académicos que se suman a las bases de datos oficiales respecto al sector cultural durante la pandemia. En este marco, el Observatorio de Políticas Culturales de la Universidad Veracruzana, registró datos de julio a diciembre de 2020 a nivel local y los comparó con actividades convocadas por agentes gubernamentales y académicos. Las artes fueron las de mayor actividad, en contraste con el patrimonio tangible e intangible. Esto puede deberse a que ha sido la tendencia de los gestores monitoreados en años anteriores, pero también a que los agentes gubernamentales lanzaron muchas convocatorias enfocadas a esta temática. Es necesario generar información constante que permita saber cómo y por qué regresar a una vida cultural activa, para el diseño e implementación de políticas culturales. Mexico has spent a year in social isolation at home due to the COVID-19 pandemic. Surveys and academic analyses emerged that add to the official databases regarding the cultural sector during the pandemic. Within this framework, the Observatory of Cultural Policies of the Universidad Veracruzana recorded data from July to December 2020 at the local level and compared them with activities organized by governmental and academic agents. The arts were the most active, in contrast to tangible and intangible heritage. This may be due to the fact that this has been the trend of the managers monitored in previous years, but also to the fact that government agents have launched many calls for proposals focused on this topic. It is necessary to generate constant information that allows us to know how and why to return to an active cultural life, for the design and implementation of cultural policies.Keywords: Cultural Managment; COVID-19; Cultural Policies; Arts; Heritage
Datos de la encuesta estilos de vida saludables en el contexto de la contingencia por COVID-19 en adultos-jóvenes veracruzanos
Authors: Arellanez Hernández Jorge Luis , Beltrán Guerra León Felipe , Romero Pedraza Enrique , Cortés Flores Erika , Ruiz Libreros Martha Elba 
Published: April 2021

El artículo de datos presenta resultados preliminares de la encuesta Estilo de Vida en el contexto de la contingencia por COVID-19 en adultos-jóvenes veracruzanos, realizada en el mes de junio de 2020 como parte de la batería de instrumentos utilizada en el estudio “Ansiedad, depresión, estilos de vida y bienestar en el contexto sociocultural actual”. Los resultados de las variables presentadas dan cuenta de los estilos de vida reportados en de seis dimensiones: alimentación, actividad física, estado emocional, relaciones sociales, consumo de alcohol, tabaco y otras drogas, y cuidado en la salud, partiendo del supuesto de que el confinamiento social que se vive derivado de la contingencia por COVD-19 repercute de manera distinta ente los hombres y las mujeres. Se encontró que, de los 301 casos que respondieron la totalidad de la encuesta, 76% fueron mujeres y 24% hombres. Las mujeres reportaron un estilo de vida más saldable en su alimentación (consumo de futas y verduras diariamente, pocas bebidas con alto contenido de azúcar, por ejemplo), actividad física (practicar algún deporte, de bajo riesgo, menor frecuencia en el uso de redes sociales, televisión o videojuegos), un mejor estado emocional (control de sentimientos, confianza en el futuro y reconocimiento social), mejores relaciones sociales (apoyo familiar, relaciones favorables con amigos, compañeros), mayor interés por el cuidado de su salud física (chequeos médicos, medidas preventivas ante enfermedades), y mayor cuidado en la salud sexual y reproductiva (uso de métodos anticonceptivos, por ejemplo). Los varones por su parte, mostraron un estilo de vida más precario al reconocer mayor ingesta de alimentos “chatarra”, altamente azucarados, práctica de deportes más riesgosos (patineta, parkour -Trepar y saltar por muros haciendo acrobacias-, por ejemplo), mayor tiempo de exposición en redes sociales, televisión o videojuegos, percibir menor apoyo familiar y reconocimiento social, reportar mayor consumo de alcohol, tabaco y otras drogas (mariguana, cocaína, etc.); y estar expuestos ciertos riesgos de transmisión sexual o embarazos al tener más de una pareja sexual. Como puede apreciarse, si bien se parte del supuesto de que la calidad de vida se ha trastocado por el confinamiento ante la pandemia por COVID-19, se observan una serie de prácticas de cuidado de la salud en las mujeres en comparación con los varones, dejando entrever una serie de roles tradicionales de género, lo que lleva a la necesidad de analizar en estas características a mayor profundidad.
Efficacy and safety of polyethylene glycol dural sealant system in cranial and spinal neurosurgical procedures: Meta-analysis
Authors: Diab Ahmed , Al-Shami Hieder , Negida Ahmed , Gadallah Ahmed , Farag Hossam , Elkadi Doaa Mahmoud , Gaber Mo’tasem Muhamed , Ebada Mahmoud Ahmed 
Published: April 2021

Background:We aimed to assess the efficacy of polyethylene glycol (PEG) dura sealant to achieve watertight closure, prevention of cerebrospinal fluid (CSF) leak and to investigate its possible side effects.Methods:We searched Medline (through PubMed), Scopus, and the Cochrane Library through December 2019. We included articles demonstrating cranial or spinal procedures with the use of PEG material as a dural sealant. Data on intraoperative watertight closure, CSF leak, and surgical complications were extracted and pooled in a meta-analysis model using RevMan version 5.3 and OpenMeta (Analyst).Results:Pooling the controlled trials showed that PEG resulted in significantly more intraoperative watertight closures than standard care (risk ratio [RR] = 1.44, 95% confidence interval [CI] [1.24, 1.66]). However, the combined effect estimate did not reveal any significant difference between both groups in terms of CSF leaks, the incidence of surgical site infections, and neurological deficits (P= 0.7, 0.45, and 0.92, respectively). On the other hand, pooling both controlled and noncontrolled trials showed significance in terms of leak and neurological complications (RR = 0.0238, 95% CI [0.0102, 0.0373] and RR = 0.035, 95% CI [0.018, 0.052]). Regarding intraoperative watertight closure, the overall effect estimate showed no significant results (RR=0.994, 95% CI [0.986, 1.002]).Conclusion:Dura seal material is an acceptable adjuvant for dural closure when the integrity of the dura is questionable. However, marketing it as a factor for the prevention of surgical site infection is not scientifically proved. We suggest that, for neurosurgeons, using the dural sealants are highly recommended for duraplasty, skull base approaches, and in keyhole approaches.
An unusual case of lead migration in occipital nerve stimulation: A case report and literature review
Authors: Caiado Vencio Rafael , Raffa Paulo Eduardo Albuquerque Zito , Ponce André Costa Corral , Malamud Bruno Pricoli , Pacheco César Cozar , Franceschini Paulo Roberto , Medeiros Roger Thomaz Rotta , de Aguiar Paulo Henrique Pires 
Published: April 2021

Background:
Lead migration is a complication associated with occipital nerve stimulation (ONS). We present a rare case in which fibrosis in the stress relief loop caused lead migration in the treatment of occipital neuralgia.

Case Description:
A 30-year-old woman with a 5-year history of refractory occipital neuralgia, who had been under ONS therapy for 2 months, presented with a sudden onset of typical occipital neuralgia pain associated with cervical muscles spasms and myoclonus. A skull radiography showed lead migration. The patient underwent surgery for lead repositioning. During surgery, we identified extensive fibrosis throughout the stress relief loop that produced several constriction points. The fibrosis in the stress relief loop increased tension on the lead during head-and-neck movement, causing progressive migration of the lead.

Conclusion:
Although lead migration is a common complication of ONS, its association with fibrosis in the stress relief loop has not, to the best of our knowledge, been reported before. Lead migration can directly affect treatment outcome and it is, therefore, important to fully understand the possible mechanisms that can cause it and how to promptly manage them.
Minimally invasive treatment strategy for partially thrombosed anterior inferior cerebellar artery aneurysm: A case report
Authors: Inoue Hirotaka , Kawano Takayuki , Kaku Yasuyuki , Mukasa Akitake 
Published: April 2021

Background:
Partially thrombosed anterior inferior cerebellar artery (AICA) aneurysms are extremely rare; thus, no established therapeutic approach exists.

Case Description:
We report a large, partially thrombosed AICA aneurysm and discuss its therapeutic nuances. The aneurysm was asymptomatic; therefore, we aimed to treat it through a minimally invasive procedure. The aneurysm was of fusiform type and the proximal neck of the aneurysm was positioned at midline in front of the brainstem. To approach the neck, posterior transpetrosal approach is recommended. However, this approach can be invasive; thus, we performed distal clipping of the aneurysm using transcondylar fossa approach with occipital artery-AICA bypass to avoid ischemia of the AICA territory. Although the size of the aneurysm initially increased, it subsequently decreased.

Conclusion:
This is a rare case report describing the long-term clinical course after distal clipping in detail. We showed that traditional microsurgical techniques can be applied to treat patients with new, minimally invasive treatment strategies.
Acute nontraumatic subdural hematoma from ruptured accessory meningeal artery pseudoaneurysm
Authors: O’Neill Brannan E. , Wozny Thomas , Uluc Kutluay , Liu Jesse J. 
Published: April 2021

Background:
Cerebral angiography including internal and external carotid artery injections is crucial in young patients with a spontaneous subdural hematoma.

Case Description:
We present the first reported case of an accessory meningeal artery aneurysm in a 46-year-old male with a history of hypertension that led to a spontaneous nontraumatic acute subdural hematoma. A PubMed review of the literature was performed using a keyword search to identify cases examining nontraumatic spontaneous intracranial hematomas related to meningeal artery aneurysms. The literature review summarizes all published reports of middle meningeal artery aneurysms resulting in nontraumatic acute intracranial bleeds. The patient underwent successful coiling of the accessory meningeal artery.

Conclusion:
We propose endovascular treatment for accessory meningeal artery aneurysms and emphasize the utility of angiography of internal and external carotid arteries in a patient with an unexplained intracranial hematoma.
A rare appearance of the trigeminocardiac reflex during resection of posterior parasagittal meningioma
Authors: Recinos Miguel A. , Hsieh Jason , Mithaiwala Hussain , Mucci Joti Juneja , Recinos Pablo F. 
Published: April 2021

Background:
Although a well-recognized phenomenon of the tentorium and posterior fossa, the trigeminocardiac reflex (TCR) has been rarely reported during surgery involving the posterior falx cerebri.

Case Description:
We present the case of a 63-year-old woman who underwent repeat resection of an atypical parasagittal meningioma involving the posterior falx. During resection, TCR was repeatedly elicited during manipulation and coagulation of the falx. Air embolism and cardiac etiologies were initially considered while TCR was not suspected, given the location. Ultimately, TCR was recognized when asystole self-resolved upon cessation of stimulus and due to its reproducibility.

Conclusion:
Awareness by the anesthesiologist and neurosurgeon of the possibility of TCR during falcine procedures can help with rapid identification to avoid a potentially catastrophic outcome.