bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular phylogeny of Nabidae (Hemiptera: Heteroptera: Cimicomorpha): insight into relationships and reclassification with the proposal of the new tribe Stenonabini
Authors: Kim Junggon , Roca‐Cusachs Marcos , Jung Sunghoon 
Published: August 2021

AbstractNabidae is a small predatory family within Cimicomorpha; however, the internal classification within this family has been unclear and controversial, confusing researchers in various fields. This study presents the first comprehensive phylogenetic analysis of Nabidae based on a molecular dataset comprising 16 outgroup and 40 ingroup taxa. A total of 3791 base pairs of mitochondrial (16S, cytochrome oxidase subunit I) and nuclear (18S, 28S) sequences were analyzed based on parsimony, maximum likelihood and Bayesian inference. Topologies from all analyses were largely congruent. Except for the paraphyly of the second largest genus, Himacerus Wolff, Nabidae and all its subgroups were monophyletic. Based on the result, the validity of the genus Stalia Reuter was confirmed, and phylogenetic relationships of the clades at the genus level were discussed. Finally, a revised classification with the Stenonabini trib.n. is proposed. In addition, molecular dating analysis was used to estimate divergence times within Nabidae. Estimation based on the Bayesian framework revealed that the divergence between Nabinae and Prostemmatinae occurred during the Late Jurassic (152–154.44 Ma). Subsequently, most of the groups in Nabidae diversified in the Late Cretaceous. Based on the estimation result, we hypothesized that Nabinae has evolved and diversified with adaptation to angiosperm plants.
Investigation of a Combined Refrigeration and Air Conditioning System Based on Two-Phase Ejector Driven by Exhaust Gases of Natural Gas Fueled Homogeneous Charge Compression Ignition Engine
Authors: Khaliq Abdul , Almohammadi Bandar A. , Alharthi Mathkar A. , Siddiqui Mohd Asjad , Kumar Rajesh 
Published: August 2021

Abstract
A natural gas-fueled homogeneous charge compression ignition (HCCI) engine is coupled to an exhaust gas operated turbine driven two-phase ejector cycle to generate power and cooling energy, simultaneously. By establishing a thermodynamic model, the simulation of the proposed system and its parametric analyses are conducted. Energetic and exergetic investigations are carried out to study the role of equivalence ratio, engine speed, condenser temperature, refrigeration evaporator temperature, air-conditioning evaporator temperature, and ejector nozzle efficiency on the thermodynamic performance parameters of the combined cycle. The analysis of two-phase ejector cooling cycle using three working fluids including R717, R290, and R600a is conducted. Results reveal that the thermal efficiency of HCCI engine is increased from 47.44% to 49.94%, and for the R600a operated combined cycle it is increased from 60.05% to 63.26% when the equivalence ratio is promoted from 0.3 to 0.6. Distribution of fuel exergy results show that out of 100% exergy input, in case of R717 operated combined cycle, 139.79 kW (38.72%) is the total exergy output, and 164.21 kW (45.49%) and 57 kW (15.79%) are the values for exergy destruction and exergy losses. It is further shown that change in refrigerant minorly influence the percentages of exergy distribution.
Architected Tunable Structure for Improved Capability in Extreme Environments
Authors: Salehii Mahtab , Yandt Scott , Schaenzer Megan , Pham Minh Quan , Kibsey Mitch , Innes Matthew , Villien Benoit , Riedel Donna , Delaby Lucas , Gerendas Miklos , Shanian Ali , Backman David 
Published: August 2021

Abstract
A novel patterned-void structure is developed to improve the fatigue life compared with conventional circular cooling holes typically used in gas turbine components exposed to high temperatures. The distinctive S-shape of the voids and their specific arrangement enable manipulation of the structure's macroscopic stiffness and Poisson's ratio. An investigation of the isothermal and thermomechanical fatigue (TMF) properties of the proposed structure is carried out in strain-controlled conditions. The testing is performed on tubular specimens machined from a Nickel-based superalloy commonly used in gas turbine combustion systems (HAYNES 230®). The isothermal fatigue tests, performed at 300 °C, 600 °C, and 800 °C, demonstrated an increase in crack-initiation life of the proposed structure by a factor of up to 28 compared with the standard circular holes. The thermomechanical fatigue tests, performed across temperature ranges 300 °C–750 °C and 300 °C–850 °C, and using in-phase (IP) and out-of-phase (OP) strain ratios, demonstrated an increase in crack-initiation life by a factor of up to 16. The life after crack initiation (crack-propagation mode) was also shown to be longer for the proposed structure, which is attributed to a crack-arresting behavior inherent to the structure.
Features of the Dynamical Evolution of a Massive Disk of Trans-Neptunian Objects
Authors: Emel’yanenko V. V. 
Published: August 2021

Abstract—
The dynamical features of a massive disk of distant trans-Neptunian objects are considered in the model of the formation of small bodies in the Hill region of a giant gas-dust clump that arose as a result of gravitational instability and fragmentation of the protoplanetary disk. The dynamical evolution of the orbits of small bodies under the action of gravitational perturbations from the outer planets and self-gravity of the disk has been studied for a time interval of the order of a billion years. It is shown that the secular effects of the gravitational influence of a massive disk of small bodies lead to an increase in the eccentricities of the orbits of individual objects. The result of this dynamical behavior is the creation of a flux of small bodies coming close to the orbit of Neptune. The change in the number of objects surviving in the observable region of distant trans-Neptunian objects (the region of orbits with perihelion distances of 40 < q < 80 AU and semimajor axes 150 < a < 1000 AU), over time depends on the initial mass of the disk. For disks with masses exceeding several Earth masses, there is a tendency to a decrease in the number of distant trans-Neptunian objects surviving in the observable region after evolution for a time interval of the order of the age of the Solar System, with an increase in the initial mass. On the other hand, for most objects, orbital eccentricities decrease under the influence of the self-gravity of the disk. Therefore, the main part of the disk is preserved in the region of heliocentric distances exceeding 100 AU.
Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAFV600E-Mutant Human Glioma
Authors: Schreck Karisa C. , Morin Andrew , Zhao Guisheng , Allen Amy N. , Flannery Patrick , Glantz Michael , Green Adam L. , Jones Chris , Jones Kenneth L. , Kilburn Lindsay B. , Nazemi Kellie J. , Samuel David , Sanford Bridget , Solomon David A. , Wang Jiawan , Pratilas Christine A. , Nicolaides Theodore , Mulcahy Levy Jean M. 
Published: August 2021

Abstract

Purpose:
Selective RAF-targeted therapy is effective in some patients with BRAFV600E-mutated glioma, though emergent and adaptive resistance occurs through ill-defined mechanisms.

Experimental Design:
Paired pre-/post- RAF inhibitor (RAFi)-treated glioma samples (N = 15) were obtained and queried for treatment-emergent genomic alterations using DNA and RNA sequencing (RNA-seq). Functional validation of putative resistance mechanisms was performed using established and patient-derived BRAFV600E-mutant glioma cell lines.

Results:
Analysis of 15 tissue sample pairs identified 13 alterations conferring putative resistance were identified among nine paired samples (including mutations involving ERRFI1, BAP1, ANKHD1, and MAP2K1). We performed functional validation of mechanisms of resistance, including loss of NF1, PTEN, or CBL, in BRAFV600E-mutant glioma lines, and demonstrate they are capable of conferring resistance in vitro. Knockdown of CBL resulted in increased EGFR expression and phosphorylation, a possible mechanism for maintaining ERK signaling within the cell. Combination therapy with a MEKi or EGFR inhibitor was able to overcome resistance to BRAFi, in NF1 knockdown and CBL knockdown, respectively. Restoration of wild-type PTEN in B76 cells (PTEN−/−) restored sensitivity to BRAFi. We identified and validated CRAF upregulation as a mechanism of resistance in one resistant sample. RNA-seq analysis identified two emergent expression patterns in resistant samples, consistent with expression patterns of known glioma subtypes.

Conclusions:
Resistance mechanisms to BRAFi in glioma are varied and may predict effective precision combinations of targeted therapy, highlighting the importance of a personalized approach.
Cytotoxic Engineered Induced Neural Stem Cells as an Intravenous Therapy for Primary Non–Small Cell Lung Cancer and Triple-Negative Breast Cancer
Authors: Mercer-Smith Alison R. , Jiang Wulin , Bago Juli R. , Valdivia Alain , Thang Morrent , Woodell Alex S. , Montgomery Stephanie A. , Sheets Kevin T. , Anders Carey K. , Hingtgen Shawn D. 
Published: August 2021

Abstract
Converting human fibroblasts into personalized induced neural stem cells (hiNSC) that actively seek out tumors and deliver cytotoxic agents is a promising approach for treating cancer. Herein, we provide the first evidence that intravenously-infused hiNSCs secreting cytotoxic agent home to and suppress the growth of non–small cell lung cancer (NSCLC) and triple-negative breast cancer (TNBC). Migration of hiNSCs to NSCLC and TNBC in vitro was investigated using time-lapse motion analysis, which showed directional movement of hiNSCs to both tumor cell lines. In vivo, migration of intravenous hiNSCs to orthotopic NSCLC or TNBC tumors was determined using bioluminescent imaging (BLI) and immunofluorescent post-mortem tissue analysis, which indicated that hiNSCs colocalized with tumors within 3 days of intravenous administration and persisted through 14 days. In vitro, efficacy of hiNSCs releasing cytotoxic TRAIL (hiNSC-TRAIL) was monitored using kinetic imaging of co-cultures, in which hiNSC-TRAIL therapy induced rapid killing of both NSCLC and TNBC. Efficacy was determined in vivo by infusing hiNSC-TRAIL or control cells intravenously into mice bearing orthotopic NSCLC or TNBC and tracking changes in tumor volume using BLI. Mice treated with intravenous hiNSC-TRAIL showed a 70% or 72% reduction in NSCLC or TNBC tumor volume compared with controls within 14 or 21 days, respectively. Safety was assessed by hematology, blood chemistry, and histology, and no significant changes in these safety parameters was observed through 28 days. These results indicate that intravenous hiNSCs-TRAIL seek out and kill NSCLC and TNBC tumors, suggesting a potential new strategy for treating aggressive peripheral cancers.
Lp(a)‐Associated Oxidized Phospholipids in Healthy Black and White Participants in Relation to apo(a) Size, Age, and Family Structure
Authors: Berglund Lars , Kim Kyoungmi , Zhang Wei , Prakash Nishant , Truax Kevin , Anuurad Erdembileg , Enkhmaa Byambaa 
Published: August 2021

Background
Lp(a) (lipoprotein(a)) is the major lipoprotein carrier of oxidized phospholipids (OxPL) and this function mediates Lp(a) atherogenicity. However, the relationship between OxPL, Lp(a), and genetic and biological characteristics remains poorly understood. We assessed the relationship between Lp(a)‐bound OxPL, apolipoprotein(a) (apo(a)) size, age, and family structure in 2 racial groups.

Methods and Results

Healthy Black and White families were recruited from the general population (age: 6–74 years, n=267). OxPL and Lp(a) levels were assayed enzymatically; apo(a) isoform,
LPA
allele sizes, and allele‐specific Lp(a) levels were determined. Lp(a)‐OxPL levels did not differ significantly by racial and age groups. Lp(a)‐OxPL levels were associated with total plasma Lp(a) in all participants and in race‐specific analyses. Further, OxPL levels were significantly associated with allele‐specific Lp(a) levels carried by the smaller apo(a) size in all participants (β=0.33,
P
=0.0003) as well as separately for Black (β=0.50,
P
=0.0032) and White (β=0.26,
P
=0.0181) participants. A significant association of OxPL with allele‐specific Lp(a) levels for larger apo(a) sizes was seen only in Black participants (β=0.53,
P
=0.0076). In this group, Lp(a)‐OxPL levels were also heritable (h
2
=0.29,
P
=0.0235), resulting in a significant interracial difference in heritability between Black and White people (
P
=0.0352).

Conclusions
Lp(a)‐OxPL levels were associated with allele‐specific Lp(a) level carried on smaller apo(a) sizes and among Black participants also for larger apo(a) sizes. The heritability estimates for Lp(a)‐bound OxPL differed by race.
Racial Disparities in Adverse Cardiovascular Outcomes After a Myocardial Infarction in Young or Middle‐Aged Patients
Authors: Garcia Mariana , Almuwaqqat Zakaria , Moazzami Kasra , Young An , Lima Bruno B. , Sullivan Samaah , Kaseer Belal , Lewis Tené T. , Hammadah Muhammad , Levantsevych Oleksiy , Elon Lisa , Bremner J. Douglas , Raggi Paolo , Shah Amit J. , Quyyumi Arshed A. , Vaccarino Viola 
Published: August 2021

Background
Black patients tend to develop coronary artery disease at a younger age than other groups. Previous data on racial disparities in outcomes of myocardial infarction (MI) have been inconsistent and limited to older populations. Our objective was to investigate racial differences in the outcome of MI among young and middle‐aged patients and the role played by socioeconomic, psychosocial, and clinical differences.

Methods and Results
We studied 313 participants (65% non‐Hispanic Black) <61 years old hospitalized for confirmed type 1 MI at Emory‐affiliated hospitals and followed them for 5 years. We used Cox proportional‐hazard models to estimate the association of race with a composite end point of recurrent MI, stroke, heart failure, or cardiovascular death after adjusting for demographic, socioeceonomic status, psychological, and clinical risk factors. The mean age was 50 years, and 50% were women. Compared with non‐Black patients, Black patients had lower socioeconomic status and more clinical and psychosocial risk factors but less angiographic coronary artery disease. The 5‐year incidence of cardiovascular events was higher in Black (35%) compared to non‐Black patients (19%): hazard ratio (HR) 2.1, 95% CI, 1.3 to 3.6. Adjustment for socioeconomic status weakened the association (HR 1.3, 95% CI, 0.8–2.4) more than adjustment for clinical and psychological risk factors. A lower income explained 46% of the race‐related disparity in outcome.

Conclusions
Among young and middle‐aged adult survivors of an MI, Black patients have a 2‐fold higher risk of adverse outcomes, which is largely driven by upstream socioeconomic factors rather than downstream psychological and clinical risk factors.
Christian Mission in the Contemporary World: A Dialogue between 1 Peter and Postcolonial Critics
Authors: Hall Josiah D. 
Published: August 2021

Abstract
The modern missions movement’s relationship with colonialism has brought to light many problems with contemporary conceptions of Christian mission. For many, the Bible often becomes, in the words of Tinyiko Sam Maluleke, the “colonial text par excellence.” This paper seeks to highlight – in dialogue with postcolonial critics – how 1 Pet 2:9–17 can instead provide the foundation for a theology of mission relevant to the contemporary context. First Peter distinctively anchors Christian mission in one’s Christian identity and clarifies how that identity transforms one’s relationship to one’s culture as well as to power structures in that culture. In doing so, 1 Peter eschews a triumphalist attitude and instead embodies values shared by theorists of postcolonial mission, namely narrativity, mutuality, and humility.
The Parable of the Good Samaritan: Two Theological Readings in the Victorian Church of England
Authors: Hartin Cole William 
Published: August 2021

Abstract
Taking seriously the reality that theological interpretation of Scripture is not a monolithic enterprise but rather a varied discussion, this paper outlines two historical contributions to the theological reading of Scripture in the Victorian Church of England. By examining the way Richard Chenevix Trench and John Keble interpret the parable of the good Samaritan, this essay shows that though both figures interpret Scripture in order to understand what it says about God, they diverge in their approach over questions of providence and ecclesial authority. The paper argues that for Trench, providence expands the scope of Scripture’s meaning but for Keble it leads to specific interpretive outcomes. Essentially, while Trench sees Scripture to be the product of divine providence, Keble sees providence to have shaped the consensus of the early Church.
The Lord of Angel Armies and the Centurion of Capernaum in Matthew 8:5–13
Authors: Wenkel David H. 
Published: August 2021

Abstract
This study of Jesus’ healing of the centurion’s servant (Matthew 8:5–13) draws attention to some neglected Christological details. This study offers a fresh explanation of how Matthew uses ambiguity and clarity about who Jesus is in various levels of narrative context. Specifically, Matthew’s characterization of the centurion uses the ambiguous title of ‘Lord’ alongside clear actions of faith to reveal Jesus’ identity. This study concludes that Jesus participates in the identity of Yahweh, who has absolute and divine power to command his army of angels to heal people and remove demons, even without his presence.
Ancient Musical Writings as Persuasive Texts
Authors: Raffa Massimo 
Published: August 2021

Abstract
This contribution is meant to shed light on how ancient Greek music theorists structure argumentations and address their readership in order to be understandable, effective and persuasive. On the one hand, some of the most important treatises, e.g. Ptolemy’s Harmonics (with Porphyry’s Commentary) and what remains of Archytas’ and Theophrastus’ works, are taken as case studies; on the other hand, the paper deals with some argumentative patterns recurring in harmonics demonstrations, especially with reference to the usage of everyday life experience as evidence supporting acoustic and harmonic theories.
The Teacher of Dance
Authors: Robinson Clifford A. 
Published: August 2021

Abstract
The De musica of Aristides Quintilianus, an author and music theorist unknown apart from this treatise, presents several tantalizing claims about the relationship between dance and the three sciences of mousikē: i.e., harmonics, metrics, and, most importantly, rhythmics. Elliptical as his remarks on dance may be, if they are taken together with his treatment of the musical phenomena as essentially governed by systēmata, both a technical discourse around dance can be elicited from the evidence as well as the philosophical and aesthetic reasons why such a discourse was so modestly developed in comparison with the three sciences attending to musical phenomena. I conclude that the theorist considers the dancing body to be only minimally conformable to the systēmata imposed on bodies by the Platonic demiurge’s art, almost as a leimma unassimilable to the perfections of musical order, and yet somehow orderly enough to be treated according to their proportional order.
Epigrafia musicale nel mondo romano
Authors: Zangrando Alessia 
Published: August 2021

Abstract
Some representative issues were revealed in a few emblematic case studies regarding musical data in Latin epigraphy. Some such issues are a complex relationship between texts and images, and the symbolic meaning of some specific musical depictions. Therefore, in order to add new information to what we know about the ancient Roman soundscape, it is necessary to tackle this question by taking an intercultural approach.
The Impact of covid-19 Measures on the Rule of Law in the Western Balkans and the Increase of Authoritarianism
Authors: Hoxhaj Andi , Zhilla Fabian 
Published: August 2021

Abstract
This article offers a comparative analysis of the covid-19 legal measures and model of governance adopted in the Western Balkans countries (Albania, Bosnia and Herzegovina, North Macedonia, Montenegro, Serbia and Kosovo) and its impact on the state of the rule of law, and ability of parliament and civil society to scrutinise government decisions. The article assesses the governments’ approaches to introducing and enforcing covid-19 legal measures, and shows examples of how covid-19 has exposed more openly the weaknesses in the existing system of checks and balances in the Western Balkans. The article offers new insights into how covid-19 presented a new opportunity for leaders in the Western Balkans to implement further their authoritarian model of governance in undermining the rule of law. This article offers suggestions on how the EU could respond, through its accession conditionality instruments and civil society, to redirect this trend towards more state capture.
The Former Secretary General of the Council of Europe Confronting Russia’s Annexation of the Crimea and Turkey’s State of Emergency
Authors: Demir-Gürsel Esra 
Published: August 2021

Abstract
This article investigates the influence of the former Secretary General of the Council of Europe (CoE), Thorbjørn Jagland, on the responses of other CoE bodies to the systemic breaches of the core principles of the CoE in the context of two critical events: Russia’s annexation of the Crimea in 2014 and Turkey’s state of emergency that followed the attempted coup in 2016. Specifically, it examines the influence of the Secretary General’s policy preferences on the Parliamentary Assembly of the CoE and the European Court of Human Rights. The article argues that Jagland’s policy preferences in the context of these two events prioritised political expediency to the detriment of the CoE’s normative mission. The article finds that the Secretary General played a crucial role in facilitating the reversal of the sanctions imposed by the Assembly against Russia and the postponement of the processing of Turkey’s post-coup cases by the Court.