bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and Methods for Mapping and Evaluating Knowledge Translation Platforms: a Scoping Review Protocol
Authors: Schmidt Bey-Marrié , Cooper Sara , Young Taryn , Jessani Nasreen S 
Published: April 2021

Abstract
BackgroundKnowledge translation platforms (KTPs) are intermediary organisations, initiatives or networks whose intent is to bridge the evidence into action divide. Strategies and tools include collaborative knowledge production, capacity building, information exchange and dialogue to facilitate relevant and timely engagement between researchers and decision-makers and other relevant stakeholders. With the wide range of definitions and descriptions of KTPs, there is a need to (a) provide a nuanced understanding of characteristics of KTPs and (b) assess and consolidate research methods used in mapping and evaluating KTPs to inform standardised process and impact evaluation. MethodsThis scoping review will follow the recommended and accepted methods for scoping reviews and reporting guidelines. Eligibility for inclusion is: any conceptual or empirical health-related qualitative, quantitative and/or mixed method studies including (a) definitions, descriptions and models or frameworks of KTPs (including those that do not self-identify as KTPs, e.g. university research centres) and (b) research methods for mapping and/or evaluating KTPs. Searches will be carried out in PubMed, Scopus, CINAHL, EMBASE, Global Health and Web of Science using search terms and synonyms for ‘knowledge translation platform’ and ‘evidence-informed decision-making’, without any date, language or geographic restrictions. Two reviewers will independently screen titles and abstracts. One reviewer will complete data extraction for all included studies, and another will check a sample of 50% of the included studies. All reviewers will be involved in the analysis process. The analysis and synthesis will provide: (a) an understanding of the various characteristics of KTPs; b) insight into characteristics or factors that make them resilient and/or adaptive to facilitate impact (i.e. influence policy and practice); and (c) an overview of the different methods for mapping and evaluating KTPs.DiscussionResults of the three aims above, will permit us to explore enhancing an existing matrix or framework for classifying KTPs or perhaps even developing a new framework for identifying and monitoring KTPs if necessary and relevant. This would be a helpful first step in establishing as well as evaluating KTPs.
Tropical Cyclogenesis Associated with Premonsoon Climatological Dryline over the Bay of Bengal
Authors: Akter Nasreen 
Published: April 2021

Abstract
Tropical cyclones of the Bay of Bengal (BoB) that formed near the synoptic-scale dryline usually intensified over a short distance (~600-800 km) within 3 days and caused severe destruction after landfall. High-resolution simulations of very severe cyclonic storms in association with dryline indicate that the meridional shear aids in the development of a group of linear convective cells that mature as an east-west oriented quasi-linear convective system (QLCS) within the boundary between the dry-moist air masses. The leading edge deep convections are supported by low-level moist southwesterly inflow; however, the typical mid-level mesoscale convective vortex (MCV) associated with these QLCS is unremarkable due to a very narrow trailing stratiform region within the QLCS. Supercells are likely to be organized within the QLCS due to extremely unstable atmospheric conditions resulting from a strong vertical shear of 27-39 m s−1 between 0-6 km and large convective available potential energy of >3000 J kg−1. The vertical shear veering with height causes several numbers of low-level mesovortices having diameters less than 10 km at the leading edge in the different convective stages of the QLCS. The dryline aloft in the BoB produces horizontal positive shear vorticity of the order 10–5 s−1 with higher values in the levels 850-600 hPa. The advection of intense cloud-scale cyclonic vortices (~10–3 s−1) assists and enhances a cyclonic vortex to the rear side of the QLCS that performs as an MCV for cyclogenesis over the BoB.
Comparing downstream testing and costs between exercise stress echocardiography and cardiac computed tomography angiography in patients suspected of having of obstructive coronary artery disease: a retrospective cohort study.
Authors: Madigan Cory , Adams Michael B , Chu Chu-Chiao , Dinkha Laith R , Farrell Samuel J , Hoard Robert T , Keithler Andrea N , Loudermilk Kevin A , Rouse Jessica , Walker Brandon L , Williams Susan G , Wyatt Andrew C , Gore Rosco S , Thomas Dustin M 
Published: April 2021

Abstract
Purpose – To compare overall number of downstream tests and total costs between initial exercise stress echocardiography (ESE) or cardiac computed tomography angiography (CCTA) in symptomatic, low to intermediate risk patients suspected of having coronary artery disease (CAD). Methods – This is a retrospective cohort study which initially screened 11,636 symptomatic patients without known CAD who underwent noninvasive evaluation between 2008–2014. Of these, and after applying prespecified exclusion criteria, 1,612 underwent ESE or CCTA. A total of 651 patients were included after performing propensity-matching for known risk factors for CAD. The total number of additional downstream tests over the next five years was determined. The total costs associated with each arm, inclusive of the initial test and all subsequent tests, was calculated using the 2018 Medicare Physician Fee Schedule. Results – 18.5 percent of patients with a normal ESE result underwent some additional form of cardiac testing over the five years after initial testing compared to 12.8 percent of patients with a normal CCTA. The absolute difference in total number of downstream tests between both study groups was 5.7 percent (p = 0.03). When factoring the costs of the initial test as well as the downstream tests, the ESE group was associated with overall lower costs compared to the CCTA group, 351 United States Dollars (USD) versus 496 USD (p < 0.0001). Conclusion – This study demonstrates that, when compared to CCTA, ESE is associated with a higher total number of downstream tests, but overall lower total costs when chosen as initial testing strategy for suspected CAD.
The Impact of Race, and Insurance Status on Breast Cancer Screening: Results from the Behavioral Risk Factor Surveillance System Data
Authors: Yoda Salamata , Mallow Jennifer , Theeke Laurie A. 
Published: April 2021

Abstract
Purpose

Breast cancer is the second major cause of cancer-related death of women in the United States 1, yet current gaps exist in breast cancer screening for minority women 2. The purpose of this study is to address these gaps by assessing the relationships among race, health insurance coverage, and breast cancer screening in a nationally representative sample of women.
Design:

A cross-sectional descriptive analysis of the 2018 BRFSS survey data was used to meet the study purpose. BRFSS participants who declared themselves to be of female sex and who were adults with the age ≥ of 40 years were selected for inclusion.
Methods

Data were analyzed using SPSS version 26. Exploratory and descriptive analyses were performed, followed by comparative analyses based on the variable type. Relationships between race, insurance status, and mammogram screening were examined. Chi-square, logistic, and multinomial logistic regression were used.
Findings:

The original 2018 BRFSS dataset included 437,436 participants and 145,837 women were selected based on inclusion criteria. Participant age ranged from 40 to 74 years. The majority were White only non-Hispanic (78.1%), reported having a mammogram in the past two years (76.1%), had earned < a 4-year college degree (61.1%), had an annual income of < $75,000 (58.4%) and married (58.2%). Less than half had a healthcare plan through an employer (44.9%) and were employed (40.5%). Participants who had a plan purchased through an employer or union were more likely to have a mammogram in the past two years when compared with other health coverage. Furthermore, White only, non-Hispanics were 1.25 times more likely and Black only, non-Hispanics were 1.98 times more likely to have a mammogram in the past two years compared to participants from other racial and ethnic groups.
Conclusion

The findings of this study provide an additional indication that race, and health insurance status do impact breast cancer screening.
Clinical Relevance:

Knowledge gained from this study can be used by practicing nurses to educate racial and ethnic minority women on the significance of breast cancer screening and prevention.
Cardiac Resynchronization Therapy Using Left-bundle-branch Area Pacing and Coronary Sinus Pacing
Authors: Feng Xiang-Fei , Zhang Rui , Yu Yi-Chi , Liu Bo , Han Ya-Qin , Lu Qiu-Fen , Li Yi-Gang 
Published: April 2021

Abstract
Background: Cardiac resynchronization therapy via biventricular pacing (BVP) is an established therapy for patients with heart failure. Recently, it has been shown that left bundle branch area pacing (LBBAP) is feasible and may also improve clinical outcomes. In this article, we describe a new technique (sequential LBBAP followed by coronary sinus pacing, designated LOT-CRT) and assess the feasibility of LOT-CRT.Methods: The database of all patients from single centre was reviewed retrospectively. The eligible patients were divided into two groups randomly, LOT-CRT and BV-CRT. The LBBAP lead implanted using our methods. The QRS duration (QRSd) was measured at baseline and during LBBAP, BVP, and LOT-CRT.Results: The study enrolled 11 consecutive heart failure patients with LBBB. LBBAP failed in 1 patient, succeed in 5 patients, while CS leads were implanted successfully in all patients. At baseline, the two groups (5 LOT-CRT cases in group 1, 6 BV-CRT cases in group 2) were matched for QRSd and ischemic cardiomyopathy (ICM, 3 cases in group 1, 2 cases in group 2). In group 1, BVP resulted in significant reduction of the QRSd from 158.0 ± 13.0 ms at baseline to 132.0 ± 4.5 ms (P=0.019). Compared with BVP, unipolar LBBAP resulted in further reduction of the QRSd to 123.0 ± 5.7 ms (P < 0.01). However, LOT-CRT resulted in a significantly greater reduction of the QRSd to 117.0 ± 6.7 ms (P < 0.01). In group 2, BVP resulted in significant reduction of the QRSd from 176.7 ±19.7 ms at baseline to 143.3 ±8.2 ms (P=0.011). However, compared with LBBAP, BVP resulted in increase of the QRSd (P >0.05). As compared to the baseline after 3 months of LBBAP, patients in group 1 showed significant improvement in LVEF and NT-proBNP levels (P < 0.01), while patients in group 2 showed non-significant changes in these parameters (P >0.05).Conclusions: The study demonstrates that LOT-CRT is clinically feasible in patients with systolic HF and LBBB. LOT-CRT was associated with significant narrowing of the QRSd and improvement in LV function, especially in patients with ICM.
Attenuated, Symptom-specific Alteration of Structural Covariance in Patients With Somatic Symptom Disorder
Authors: Park Hye Youn , Jang Ye Eun , Sunwoo Leonard , Yoon In-Young , Park Bumhee 
Published: April 2021

Abstract
This study was performed to investigate altered regional gray matter volume (rGMV) and structural covariance related to somatic symptom disorder (SSD) and its phenotypic subtypes. Additionally, this study examined the relationships of structural alteration with cognitive functioning and clinical symptoms. Forty-three unmedicated patients with SSD and thirty normal controls completed psychological questionnaires and neurocognitive tests, as well as brain magnetic resonance imaging. Voxel-based morphometry and structural covariances were compared between groups and between subgroups within the SSD group. Patients with SSD exhibited attenuated structural covariances in the pallidal-cerebellar circuit, as well as regions in the default mode and sensorimotor network, compared to normal controls. The cerebellar rGMVs were negatively correlated with the severity of somatic symptoms. With respect to cognitive functioning, the rGMVs of the right pallidum, left medial orbitofrontal gyrus, and bilateral supramarginal gyrus were correlated with attentional capacity in SSD patients. In subgroup analyses, patients with somatic pain showed denser structural covariances between the bilateral superior temporal pole and left angular gyrus, the left middle temporal pole and left angular gyrus, and the left amygdala and right inferior orbitofrontal gyrus, while patients with headache and dizziness had greater structural covariance between the right inferior temporal gyrus and right cerebellum. The findings revealed the structural alteration involved in SSD; they also suggested that specific brain regions and networks may contribute to different subtypes of SSD.
Competitive ELISA for a serologic test to detect dengue serotype-specific anti-NS1 IgGs using high-affinity UB-DNA aptamers
Authors: Matsunaga Ken-ichiro , Kimoto Michiko , Lim Vanessa Weixun , Vasoo Shawn , Leo Yee Sin , Sun William , Hirao Ichiro 
Published: April 2021

Abstract
Serologic tests to detect IgGs specific to antigens related to viral infections are urgently needed for diagnostics and therapeutics in endemic, epidemic, and pandemic situations. We present a diagnostic method for serotype-specific IgG identification of dengue infection by a competitive enzyme-linked immunosorbent assay (ELISA), using high-affinity unnatural-base-containing DNA (UB-DNA) aptamers. Dengue is a widespread mosquito-borne viral disease, with four categorized serotypes. Using UB-DNA aptamers that bind specifically to each serotype or sub-serotype dengue NS1 protein (DEN-NS1), we developed an ELISA format with an aptamer − antibody sandwich system for dengue diagnostics. We found that IgGs highly specific to DEN-NS1 inhibit the serotype-specific NS1 detection by the ELISA format, inspiring us to develop another competitive ELISA format for serotype-specific IgG detection of dengue infection. Analyses of clinical blood samples from Singaporean patients with primary or secondary infections confirmed the highly specific IgG detection of this format, and the IgG production initially reflected the serotype of the past infection, rather than that of the recent infection. The combination of the ELISA and competitive ELISA using the UB-DNA aptamers allows the diagnosis of both past and current viral infections and will facilitate prompt and specific medical care and vaccine development for infectious diseases.
Quantitative Trait Loci (QTL) Associated With Leaf Development in Winter Triticale (× Triticosecale Wittmack) Seedlings
Authors: Wajdzik Katarzyna , Dyda Mateusz , Golebiowska Gabriela Julia , Wędzony Maria 
Published: April 2021

Abstract
The vitality and the development in the seedling stage is crucial in winter cereal’s life cycle, especially before and during winter. It has been reported that rapid seedling establishment and early growth may lead to higher crop yield. Localization of cereal genome regions is not often analysed in the seedling stage. The aim of this study was to identify winter triticale genome regions (QTL) associated with seedling leaves development. Based on ‘Hewo’ x ‘Magnat’ DH lines population genetic map composed of 3539 molecular markers assigned to 20 linkage groups with 4997.4 cM map length, in total 40 loci were identified by a composite interval mapping (CIM). Among them, 22 loci appeared in at least two experiments, were common for all analyzed traits as well as were identified on wheat chromosome 4B and on rye chromosomes 1R, 4R, 5R and 6R. Those loci explained up to 21.7% of phenotypic variation (Qwsl.hm.4R.2) and had LOD value up to 31.1 (Qlsl.hm.5R.1). The results of QTLs of seedling leaves development could be successively associated with QTLs of the freezing and fungal infection seedlings tolerance identified in this mapping population.
Maternal Obesity and the Risk of Congenital Heart Defects: the Mediation Effect of Pregestational Diabetes
Authors: Wu Xiao-Xia , Ge Ru-Xiu , Huang Le , Tian Fu-Ying , Chen Yi-Xuan , Wu Lin-Lin , Niu Jian-Min 
Published: April 2021

Abstract
Background Congenital heart defects (CHDs) are the most common birth defects worldwide. Maternal obesity has been proposed as a risk factor for CHDs, but the results are controversial and inconclusive. Pregestational diabetes (PGDM) is well known as a risk factor for CHDs and is closely related to obesity. However, the effect of PGDM on the association between maternal obesity and CHDs has not been investigated.Objectives We aimed to explore the association between maternal obesity and CHDs and to further evaluate the mediation effect of PGDM on this association.Methods We involved 53708 mother-infant pairs with deliveries between 2017 and 2019 from the Birth Cohort in Shenzhen (BiCoS). Mothers were categorized into four groups: the underweight group (BMI < 18.5), normal weight group (18.5 ≤ BMI < 24), overweight group (24 ≤ BMI < 28) and obesity group (BMI ≥ 28). To evaluate the association between BMI and CHDs, we fit multivariable logistic regression models, adjusting for maternal age, maternal education level, mode of conception, parity, GDM and offspring sex. Mediation analysis was used to confirm the mediation effect of PGDM on the association between maternal obesity and CHDs.Results The proportion of obese individuals in the BiCoS was 2.11%. Overall, 372 (0.69%) infants were diagnosed with CHDs. The prevalence of CHDs in underweight, normal weight, overweight and obese individuals was 0.64%, 0.68%, 0.72% and 1.24%, respectively. Maternal obesity was associated with an increased risk of CHDs (OR=1.97, 95% CI 1.14–3.41). The offspring of women with PGDM were 6.88 times (95% CI 4.11–11.53) more likely to have CHDs than the offspring of mothers without PGDM. The mediation effect of PGDM on the association between maternal obesity and CHDs was significant (OR=1.18, 95% CI 1.06–1.32). The estimated mediation proportion was 24.83%.Conclusion Our findings suggested that maternal obesity was associated with CHDs and that PGDM partially mediated the association between maternal obesity and CHDs.
Soil Nutrients and Maize Yields Responses to Agroforestry Tree Post-fallows Management in Tanzania
Authors: Vyamana Vincent G. , Chamshama Shabani A.O. , Andrew Samora Macrice 
Published: April 2021

Abstract
Agriculture forms a backbone of many countries in sub-Saharan Africa (SSA) thus has the potential to contribute to achieving Sustainable Development Goals (SDGs). However, agriculture in the SSA is characterized by low production due to soil fertility depletion. Use of appropriate low input agricultural technologies may increase production and benefit smallholder farmers through increased productivity in already degraded land. A field experiment was established to assess tree coppice intercropping of Albizia harveyi and Albizia versicolor for soil fertility and maize yield improvements in Morogoro, Tanzania. Tree fallows of A. versicolor aged three years increased significantly soil organic Carbon, Calcium, Magnesium and Potassium. Yields of maize grain, cobs and stover in maize fields intercropped with A. versicolor were significantly higher than those with A. harveyi. Fields with continuous maize cropping had the least yields of grain, cobs and stover. The studied agroforestry tree species are recommended for rotational woodlots and short rotation coppice systems to enhance agricultural productivity for achieving SDGs.
Vertebral body height changes in acute symptomatic osteoporotic vertebral compression fractures treated with vertebral cement augmentation. Which factors affect vertebral body height?
Authors: Payo-Ollero Jesús , Llombart-Blanco Rafael , Villas Carlos , Alfonso Matías 
Published: April 2021

Abstract
Changes in vertebral body height depend on various factors which were analyzed in isolation and not as a whole. The aim of this study is to analyze what factors might influence restoration of vertebral body height after vertebral augmentation. We analyzed 48 patients (108 vertebrae) with osteoporotic vertebral fractures underwent vertebral augmentation when conservative treatment proved unsatisfactory. Analyses were carried out at the time of the fracture, during surgery (pre-cementation and post-cementation), at first medical check-up (6 weeks post-surgery) and at last medical check-up. Average vertebral height was measured and differences from preoperative values calculated at each timepoint. Pearson correlation coefficient and linear multivariable regression were carried out at the different timepoints. The time since vertebral fracture was 60.4 ± 41.7 days. Patients’ average age was 70.9 ± 9.3-years. The total follow-up was 1.43 ± 1-year. After vertebral cementation there was an increase in vertebral body height of + 0.3cm (13.6%). During post-operative follow-up, there was a progressive collapse of the vertebral body and pre-surgical height was reached. The factors that most influenced vertebral height restoration were: grade III collapse, intervertebral-vacuum-cleft (IVVC), and use of a flexible trocar before cement augmentation. The factor that negatively influenced vertebral body height restoration was location in the thoracolumbar spine.
Matrix metalloproteinases, purinergic signaling, and epigenetics, hubs in the spinal neuroglial network following nerve injury.
Authors: Luca Ciro De , Virtuoso Assunta , Maggio Nicola , Cerasuolo Michele , Colangelo Anna Maria , Lavitrano Marialuisa , Papa Michele 
Published: April 2021

Abstract
The neuroglial network characterizes synaptic transmission and accounts for both cellular elements (neurons and glia) and neural extracellular matrix (nECM) roles. Glial cells, neuron, and nECMnetwork is strongly interconnected, in physiological and pathological conditions as shownin several neurodegenerative diseases. Purinergic activation and matrix metalloproteinases (MMPs) remodeling of the spinal cord is pivotal in maladaptive plastic changes following peripheral nerve injury (PNI). To understand how purinergic and MMPs inhibition may modulate and potentially reverse the neuroglial network failure, we used the spared nerve injury (SNI) model of the sciatic nerve. Molecular and morphological analysis of astrocytic and microglial activation, purinergic and neurotrophic receptors, Histone Deacetylase (HDAC)1, HDAC2 were analyzed to define the pathways in response to the purinergic and MMPs inhibition. The data suggest complex protein interconnections, which are not passively influenced by epigenetics but actively contribute to modify the transcriptomics machinery. The present study contributes to unveiling the spinal network consistency and ultimately encourages new paths for targeted treatments in neurological diseases with benefits of neuroprotection, plasticity, and functional recovery.