bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practices of disciplinary symbiosis: (Re)blending theory and method, anthropology and public health
Authors: McClure Stephanie M. , Kuhlmann Anne Sebert 
Published: September 2021

AbstractBackgroundIf you are dually trained in anthropology and public health and your goal is an academic career, in what academic unit should you make your professional home? Should you be a public health‐trained academic anthropologist or an anthropologist in a public health school or program?AimsAssociate Professor of Public Health Anne Sebert Kuhlmann and Assistant Professor of Anthropology Stephanie McClure see their dual training as essential to enacting the career goal of fostering understanding of and positively affecting health in people's everyday lives and preparing students to do the same. “We credit our dual training for our robust perspectives on the nature and causes of health and illness and our recognition that theory and methods are complementary tools in teaching and research. We also recognize that though dual training brings conceptual power and functional applicability to our work, it can also be a challenge to navigate a career path that effectively blends the two. Conventional hierarchies in academia and in public health practice can position the two disciplines for conflict rather than complementarity”.Materials and MethodsIn this article, the two first review the complementarity and conflict between anthropology and public health.DiscussionNext, shifting to a conversational mode, they compare their paths to dual training, their attempts and successes at bringing those blended perspectives to bear in their current positions, and their ideas about more robustly inhabiting (within themselves) and fostering (between the disciplines) public health/anthropology collaborations.
Construction of CF3‐containing Oxepino[2,3‐c]pyrazole Motif via Sulfur Ylide‐mediated Annulation or Me2S involved One‐pot Reaction
Authors: Yang Kaichuan , Li Zhi , Sheng Yiqun , Deng Junfeng , Song Yanxia , Liu Zhenxiang , Jia Aiqiong 
Published: September 2021

AbstractBase promoted [4+3] annulation of trifluoromethylpyrazole(TFPZ) derived α,β‐unsaturated ketones with crotonate‐derived sulfur ylides provided a diverse set of CF3‐containing oxepino[2,3‐c]pyrazole motif in good to excellent yields through a simple, mild and fast manner. Significantly, one‐pot strategy could be successfully applied to this transformation from available materials. Also, the utility of our versatile protocol was further demonstrated by gram‐scale reaction and useful derivation.
Carbene‐Catalyzed Three‐Component Cascade Reaction of Benzofuran‐2‐ones and Enals: Construction of Spirobenzofuranone‐δ‐lactones
Authors: Wang Zhan‐Yong , Shen Fumin , Yang Ting , Zhang Jun‐Kai , Chen Rongxiang , Wang Kai‐Kai , Liu Hongxin 
Published: September 2021

AbstractA convenient method was developed via an NHC mediated three‐component cascade reaction for the construction of medicinally important spirobenzofuranone derivatives. The reaction features mild reaction conditions and generates three consecutive stereocenters, one of which is an all‐carbon substitution. The protocol can accommodate various substituents and substitution patterns, afford the products in moderate to good yields with excellent diastereoselectivities and moderate enantioselectivity.
Elimination of Grain Boundary Defects in Zeolitic Imidazolate Framework ZIF‐95 Membrane via Solvent‐Free Secondary Growth
Authors: Deng Aishan , Shen Xintian , Wan Zheng , Li Yanhong , Pang Shuyue , He Xiao , Caro Jürgen , Huang Aisheng 
Published: September 2021

AbstractMetal–organic framework membranes are usually prepared by in situ or secondary growth in a solution/hydrogel. The use of organic solvents may cause safety and environmental problems and produce solvent‐induced defects. Here, highly oriented and permselective ZIF‐95 membranes are prepared for the first time via a solvent‐free secondary growth method. The solvent‐free growth is not only helpful to control the membrane microstructure and thickness, but also to reduce the intercrystalline defects. In case of solvent‐free growth, a perfectly oriented structure leads to an outstanding reduction of intercrystalline defects and transport resistances. For the separation of equimolar binary gas mixtures by using the highly oriented ZIF‐95 membrane at 25 °C and 1 bar, the mixture separation factors of H2/CO2 and H2/CH4 are 184 and 140, respectively, with H2 permeance of over 1.9×10−7 mol m−2 s−1 Pa−1 which are much higher than those of the randomly oriented ZIF‐95 membrane.
A {Zn5} cluster‐based metal–organic framework: Multifunctional detection of Ag+, Cr2O72−, and 2,4,6‐trinitrophenol (TNP)
Authors: Liu Han‐Fu , Tao Ye , Wu Tai‐Xue , Li Hai‐Ye , Zhang Xiu‐Qing , Huang Fu‐Ping , Bian He‐Dong 
Published: September 2021

AbstractIt is important to develop sensors that can be easily fabricated for the detection of harmful industrial wastes and nitroaromatic explosives to reduce the risks to human health and protect the environment. We report a new luminescent metal–organic framework (MOF), [Zn5(μ3‐OH)2(TDA)4(4,4′‐bpt)2]n (1), (4,4′‐bpt = 1H‐3,5‐bis‐(4‐pyridyl)‐1,2,4‐triazole, H2TDA = thiophene‐2,5‐dicarboxylic acid), which was synthesized under solvothermal conditions and characterized using the PXRD, IR, TG, ICP‐MS, mapping, and PL spectroscopic techniques. The {Zn5} MOF of (1) with Zn5 cluster as the node, and 4,4′‐bpt and TDA2− as linkers, exhibited excellent thermal and chemical stabilities. Furthermore, 1 can serve as a sensitive and recyclable luminescent probe for the detection of Ag+, Cr2O72−, and TNP with detection limits of 5.96, 4.34, and 1.59 μM, respectively.
Process optimization of simultaneous enzymatic production of 1,3‐dioleoyl‐2‐palmitoylglycerol and 1‐oleoyl‐2‐palmitoyl‐3‐linoleoylglycerol
Authors: Sun Dongzhe , Li Shilei , Shang Jiayi , You Linna , Wang Manyi , Sun Chengguo , Wang Xiangyu 
Published: September 2021

Abstract1,3‐dioleoyl‐2‐palmitoylglycerol (OPO), a structured triacylglycerols (TAG) containing palmitic acid at sn‐2 position, is widely used as breast milk fat substitutes in infant formula. Interestingly, the main component of breast milk fat in Western countries is OPO while Chinese breast milk contains both 1‐oleoyl‐2‐palmitoyl‐3‐linoleoylglycerol (OPL) and OPO. Thus, OPL is additionally essential for Chinese infants. In the present study, we developed a process for simultaneous production of OPL and OPO. According to the fatty acid (FA) composition of Chinese breast milk, soy oil, palm kernel stearin, and palm stearin were selected as the base oils for random interesterification, and the appropriate ratio was determined as 2:3:15. Then interesterification at sn‐1,3 position was conducted, four reaction parameters were examined, where 1.6 molar ratio of oleic acid to linoleic acid (OLA/LNA), 10% enzyme quantity, TAG to FA ratio of 1:8 and reaction temperature of 56°C were ultimately established as the optimal conditions to achieve the target of the present study, and the OPO and OPL contents in the final products were 23.1% and 26.2%, respectively. Finally, molecular distillation was applied to purify above achieved breast milk fat substrates. Higher oil dropping speed, oil temperature, and agitation speed were favorable conditions, and the lowest acid value that achieved in the present study was 3.46 mgKOH/g. Overall, we established an efficient preliminary process for the simultaneous production of OPO and OPL, which could provide an important reference for commercial production of breast milk fat substrates for Chinese infants.
Synthesis, Structure and Cytotoxicity of N,N and N,O‐Coordinated RuII Complexes of 3‐Aminobenzoate Schiff Bases against Triple‐negative Breast Cancer
Authors: Mukherjee Arpan , Koley Tuhin Subhra , Chakraborty Ayan , Purkait Kallol , Mukherjee Arindam 
Published: September 2021

AbstractHalf‐sandwich RuII complexes, [(YZ)RuII(η6‐arene)(X)]+, (YZ=chelating bidentate ligand, X=halide), with N,N and N,O coordination (1–9) show significant antiproliferative activity against the metastatic triple‐negative breast carcinoma (MDA‐MB‐231). 3‐aminobenzoic acid or its methyl ester is used in all the ligands while varying the aldehyde for N,N and N,O coordination. In the N,N coordinated complex the coordinated halide(X) is varied for enhancing stability in solution (X=Cl, I). Rapid aquation and halide exchange of the pyridine analogues, 2 and 3, in solution are a major bane towards their antiproliferative activity. Presence of free −COOH group (1 and 4) make complexes hydrophilic and reduces toxicity. The imidazolyl 3‐aminobenzoate based N,N coordinated 5 and 6 display better solution stability and efficient antiproliferative activity (IC50 ca. 2.3–2.5 μM) compared to the pyridine based 2 and 3 (IC50>100 μM) or the N,O coordinated complexes (7–9) (IC50 ca. 7–10 μM). The iodido coordinated, 6, is resistant towards aquation and halide exchange. The N,O coordinated 7–9 underwent instantaneous aquation at pH 7.4 generating monoaquated complexes stable for at least 6 h. Complexes 5 and 6, bind to 9‐ethylguanine (9‐EtG) showing propensity to interact with DNA bases. The complexes may kill via apoptosis as displayed from the study of 8. The change in coordination mode and the aldehyde affected the solution stability, antiproliferative activity and mechanistic pathways. The N,N coordinated (5 and 6) exhibit arrest in the G2/M phase while the N,O coordinated 8 showed arrest in the G0/G1 phase.
Synthesis of Thin Bi9O7.5S6 Nanosheets for Improved Photodetection in a Wide Wavelength Range
Authors: Yi Ronghua , Wang Jin , Yue Xiaoping , Liang Yan , Li Zhuoyao , Sheng Huixiang , Guan Mengdan , Zhu Yameng , Sun Qizeng , Wang Li , Huang Xiao , Lu Gang 
Published: September 2021

AbstractBismuth‐based compounds possess layered structures with a variety of stacking modes, endowing the compounds with diverse properties. As one type of bismuth oxysulfides, Bi9O7.5S6 nanocrystals has great applications in photodetection; however, the responsivity of bulky Bi9O7.5S6 is limited due to the poor charge separation. Herein, single‐crystalline Bi9O7.5S6 thin nanosheets are successfully synthesized by using a solvothermal method. The thickness of the obtained Bi9O7.5S6 nanosheets is down to 15 nm and can be easily tuned by varying the reaction period. Moreover, the Bi9O7.5S6 nanosheets show strong light absorption in the visible and near infrared range, making it a promising candidate in optoelectronics. As a demonstration, the thin Bi9O7.5S6 nanosheets are used as active layer in an optoelectronic device, which exhibits sensitive photoelectric response to light in a wide range of 400–800 nm. The responsivity of the device reaches up to 1140 μA W−1, and the performance of the device is stable after long‐period illumination. This work demonstrates a great potential of the thin Bi9O7.5S6 nanosheets in optoelectronic devices, and these nanosheets may also be extended to various optoelectronic applications.
Sustainable Synthesis of 2‐Hydroxymethylbenzimidazoles using D‐Fructose as a C2 Synthon
Authors: Raja Dineshkumar , Philips Abigail , Sundaramurthy Devikala , Chandru Senadi Gopal 
Published: September 2021

AbstractD‐fructose, a biomass‐derived carbohydrate has been identified as an environmentally benign C2 synthon in the preparation of synthetically useful 2‐hydroxymethylbenzimidazole derivatives by coupling with 1,2‐phenylenediamines. Proof of concept was established by synthesizing 23 examples using BF3.OEt2 (20 mol%), TBHP (5.5 M, decane) (1.0 equiv.) in CH3CN at 90 °C for 1 h. The pivotal features of this method include metal‐free conditions, short time, good functional group tolerance, gram scale feasibility and the synthesis of benzimidazole fused 1,4‐oxazine. Control studies with conventional C2 synthons did not produce the desired product, thus suggesting a new reaction pathway from D‐fructose.
Enantioselectivity in Ruthenium‐Catalyzed Propargylic Substitution Reactions of Propargylic Alcohols with Acetone: A DFT Study
Authors: Sakata Ken , Goto Yui , Yoshikawa Takeshi , Nishibayashi Yoshiaki 
Published: September 2021

AbstractThe enantioselectivity in the propargylic substitution reactions of propargylic alcohols with acetone catalyzed by optically active thiolate‐bridged diruthenium complexes was examined via ωB97X‐D level DFT calculations. Some structures with intramolecular dispersion interactions between ligands were found for the ruthenium‐allenylidene complex, which is the key intermediate in the catalytic reaction, and it was determined that the structure corresponding to the X‐ray crystal structure, which had provided the transition state model for the enantioselectivity in previous studies, was not the most stable among the obtained structures. Then, a variety of transition‐state structures for the nucleophilic attack of prop‐1‐ene‐2‐ol, which is the enol isomer of acetone, on the γ‐carbon of the ruthenium‐allenylidene complex were explored. Among the transition‐state structures with lower energies, the number of structures leading to the major (R) product was found to be larger than that of structures leading to the minor (S) product, providing enantioselectivity in terms of probability distributions. The introduction of a phenyl group in the thiolate ligand was suggested to increase the selectivity. Thus, we propose the novel transition state model for the asymmetric catalytic reaction system.
microRNAs: Small molecules with a large impact on colorectal cancer
Authors: Moazzendizaji Sahand , Sevbitov Andrey , Ezzatifar Fatemeh , Jalili Hamid Reza , Aalii Morteza , Hemmatzadeh Maryam , Aslani Saeed , Gholizadeh Navashenaq Jamshid , Safari Roghaiyeh , Hosseinzadeh Ramin , Rahmany Mohammad Reza , Mohammadi Hamed 
Published: September 2021

AbstractColorectal cancer (CRC) accounts for one of the main cancer‐related mortality and morbidity worldwide. The molecular mechanisms of CRC development have been broadly investigated and, over the last decade, it has become evident that aberrant transcription of microRNAs (miRNAs), a class of small, noncoding RNA molecules, has a significant role in the inception and promotion of CRC. In the involved tissues of CRC, the transcription profile of miRNAs is modulated, and their expression templates are related with prognosis, diagnosis, and treatment outcomes. Here, in the current review, we attempted to discuss the latest information regarding the aberrantly expressed miRNAs in CRC and the advantages of utilizing miRNAs as biomarkers for early diagnosis and prognosis of CRC as well as potential therapeutic application. The effect of miRNAs involved in various signaling pathways, primarily p53, EGFR, Wnt, and TGF‐β pathways, was clarified.
Second‐ or third‐generation tyrosine kinase inhibitors in first‐line treatment of chronic myeloid leukemia in general population: Is there a real benefit?
Authors: Canet Jim , Cony‐Makhoul Pascale , Orazio Sébastien , Cornet Edouard , Troussard Xavier , Maynadié Marc , Étienne Gabriel , Monnereau Alain 
Published: September 2021

AbstractIntroductionSince 2009, multiple randomized trials have shown faster and deeper responses in CML patients treated with new‐generation TKI (NG‐TKI) compared to those treated with imatinib (IM). Are the same results observed in the general population?Materials and MethodsPatients were identified from the three French hematological malignancies population‐based registries. All CML patients (ICD‐O‐3: 9875/3) diagnosed between 2006 and 2016 and resided in registries areas were included. The TKI generation effect on achievement of MMR in first‐line therapy was assessed through a multivariate competitive risk analysis. An alluvial plot described the pathways leading to death.ResultsIn total, 507 CML patients received TKI in first‐line treatment, 22% were enrolled in a clinical trial. After adjustment, NG‐TKI patients were significantly more likely to achieve MMR during first‐line therapy than IM patients (HR: 1.88 CI95% [1.35–2.61]). At the end of follow‐up, 212 patients were still in first‐line therapy (46 of them died), 203 switched to second‐line (43 subsequently died), 26 were on TFR from first‐line (4 subsequently died), and 20 stopped their treatment (16 subsequently died).DiscussionIn this comprehensive real‐life setting, the results were consistent with clinical trials. The results are not sufficient to conclude that a NG‐TKI treatment is superior with regard to these patients, despite indications regarding differences between the TKI generation effect on survival and tolerance.
Engineering Leifsonia Alcohol Dehydrogenase for Thermostability and Catalytic Efficiency by Enhancing Subunit Interactions
Authors: Zhu Lu , Song Yang , Chang Chenchen , Ma Hongmin , Yang Lu , Deng Zixin , Deng Wei , Qu Xudong 
Published: September 2021

AbstractLeifsonia alcohol dehydrogenase (LnADH) is a promising biocatalyst for the synthesis of chiral alcohols. However, limitations of wild‐type LnADH observed for practical application include low activity and poor stability. In this work, protein engineering was employed to improve its thermostability and catalytic efficiency by altering the subunit interfaces. Residues T100 and S148 were identified to be significant for thermostability and activity, and the melting temperature (ΔTm) and catalytic efficiency of the mutant T100R/S148I toward ketone substrates was improved by 18.7 °C and 1.8–5.5‐fold. Solving the crystal structures of the wild‐type enzyme and T100R/S148L revealed beneficial effects of mutations on stability and catalytic activity. The most robust mutant T100R/S148I is promising for industrial applications and can produce 200 g liter−1 day−1 chiral alcohols at 50 °C by only a 1 : 500 ratio of enzyme to substrate.
Rosai‐Dorfman disease in 6‐year‐old child: Presentation, diagnosis, and treatment
Authors: Giri Kalpana , Baral Ashok , Tiwari Niva , Sharma Krishna Sagar 
Published: September 2021

AbstractRosai‐Dorfman disease is referred to as sinus histiocytosis massive lymphadenopathy. We are reporting a rare case of Rosai‐Dorfman disease, a case of 6‐year‐old boy with a history of multiple painless submandibular and cervical lymphadenopathy.
Recurrent thyrotoxic periodic paralysis with normokalemia in a 36‐year‐old man: A case report
Authors: Seife Hassen Sara , Salih Ali Mohamed , Khan Adeel , Mohammed Areej Marwan , Altermanini Mohamed , Al Mohanadi Dabia Hamad S. H. , Zahid Mohamed 
Published: September 2021

AbstractAmong patients with thyrotoxicosis and proximal muscle weakness, some patients with TPP may present with apparent normokalemia in whom a careful administration of potassium may lead to rapid reversal of muscle weakness.
Epidermoid cyst of the buccal mucosa—An uncommon entity: Case report and literature review
Authors: Dammak Nouha , Chokri Abdellatif , Slim Afef , Bellalah Ahlem , Bouguezzi Adel , Sioud Sameh , Hentati Hajer , Selmi Jamil 
Published: September 2021

AbstractEpidermoid cyst of the buccal mucosa is rare. Nevertheless, it must be included in the differential diagnosis of swelling in this area. The diagnosis is based on anatomopathological examination. The surgical enucleation is the gold standard of treatment.
Active Base Hybrid Organosilica Materials based on Pyrrolidine Builder Units for Fine Chemicals Production
Authors: Llopis Sebastián , Velty Alexandra , Díaz Urbano 
Published: September 2021

AbstractThe catalytic activity of “pyrrolidine type” fragments included or anchored in the mesoporous silica supports or polymeric frameworks have been fully reported for enantioselective transformation. Nevertheless, low attention was focused on their catalytic abilities to perform base‐catalyzed reaction. Accordingly, hybrid materials including pyrrolidine fragments in the mesoporous silica supports were prepared following different synthesis methods, such as micellar and fluoride sol‐gel routes in absence of structural directing agents. Their great catalytic performance was explored for various base‐catalyzed reactions to the formation of C−C bond through Knoevenagel, Claisen‐Schmidt and Henry condensations under microwave irradiation. The benefits of microwave irradiation combined with suitable catalytic properties of pyrrolidine hybrid materials with strong base sites and high accessibility to active centers, allowed carrying out successfully base‐catalyzed condensation reactions for the production of fine chemicals. Moreover, the hybrid catalyst exhibited high selectivity and good stability over different catalytic cycles contributing to environmental sustainability.
Identification and Insight into the Role of Ultrathin LDH‐Induced Dual‐Interface Sites for Selective Cinnamaldehyde Hydrogenation
Authors: Miao Chenglin , Zhang Fengyu , Cai Luoyu , Hui Tianli , Feng Junting , Li Dianqing 
Published: September 2021

AbstractFocusing on the simultaneous enhancement of activity and selectivity in α, β‐unsaturated aldehyde hydrogenation, we designed and prepared an ultrathin CoAl‐LDH supported Pt catalyst. A series of technologies revealed the ultrathin CoAl‐LDH support possesses the characteristic of dual defects, oxygen vacancy (VO) and cobalt vacancy (VCo). Then, two kinds of vacancy related interface sites were identified, namely Pt−VO−Coδ+ and Pt−VCo−OHδ−. Compared with the bulk catalyst, the ultrathin catalyst exhibits both enhanced intrinsic activity and C=O bond selectivity under the synergistic effect of the dual interface sites. Specifically, the Pt−VO−Coδ+ interface site changes the adsorption mode of cinnamaldehyde and promotes the activation of C=O bonds, thus leading to the improved cinnamyl alcohol selectivity. The H atoms of the Pt−VCo−OHδ− interface site participate in the hydrogenation process, which facilitates the mobility of active hydrogen and therefore promotes the intrinsic activity. More importantly, the ultrathin catalyst shows good reusability.
Manganese Oxoborate‐Based Nanostructures as Novel Oxygen Evolution Catalysts in Neutral Media
Authors: Elmaci Gokhan , Icten Okan , Ozer Demet , Ozgenc Gokhan , Ertekin Zeliha , Kose Dursun Ali , Pekmez Kadir , Zumreoglu‐Karan Birgul 
Published: September 2021

AbstractThe development of electrocatalysts for the OER (oxygen evolution reaction) process is an ongoing challenge in producing sustainable energy systems. Herein, we report QS (quasi‐spherical), IR (irregular), and NR (nanorod) Mn2OBO3 (manganese oxoborate), modified with a carbon support, as candidate electrocatalysts for OER in a neutral medium. QS‐, IR‐ and NR‐Mn2OBO3 catalysts displayed low onset potentials of 201 mV, 205 mV, and 208 mV and Tafel slope results of 94 mV dec−1, 97 mV dec−1, and 106 mV dec−1, respectively. As a result of the long‐term stability tests, it was determined that the NR‐Mn2OBO3 sample was extremely stable compared to the QS‐ and IR‐catalysts. This work introduces a new Mn2OBO3/C composite catalyst that displays efficient OER performance at a neutral medium and provides a different perspective for catalyst development strategies.
Lap: A latency‐aware parallelism framework for content‐based publish/subscribe systems
Authors: Zhu Weidong , Qian Shiyou , Xu Jiawei , Xue Guangtao , Cao Jian , Zhu Yanmin , Li Wenjuan 
Published: September 2021

SummaryWhen large‐scale content‐based publish/subscribe systems face dynamic workloads, it is challenging to stabilize event delivery latency. In this article, we propose a latency‐aware parallelism framework (Lap) to address this challenge. Specifically, we propose a lightweight parallelism method called PhSIH for event matching algorithms. In addition, we design a reactive parallelism degree adjustment (RPDA) mechanism in the backpressure way to determine the parallelism degree. We implement Lap in Apache Kafka and evaluate the parallelism effect of PhSIH and the adaptability of RPDA on trace data. The experiment results demonstrate that PhSIH achieves linear speedup on three existing algorithms and RPDA possesses a desirable adaptability to the dynamic workloads.