bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dig out, Dig in! Plant-based diet at the Late Bronze Age copper production site of Prigglitz-Gasteil (Lower Austria) and the relevance of processed foodstuffs for the supply of Alpine Bronze Age miners
Authors: Heiss Andreas G. , Jakobitsch Thorsten , Wiesinger Silvia , Trebsche Peter 
Published: March 2021

This paper starts from theoretical and methodical considerations about the role of archaeobotanical finds in culinary archaeology, emphasizing the importance of processed cereal preparations as the “missing link” between crop and consumption. These considerations are exemplified by the discussion of abundant new archaeobotanical data from the Late Bronze Age copper mining site of Prigglitz-Gasteil, situated at the easternmost fringe of the Alps. At this site, copper ore mining in opencast mines took place from the 11thuntil the 9thcentury BCE (late Urnfield Culture), as well as copper processing (beneficiation, smelting, refining, casting) on artificial terrain terraces. During archaeological excavations from 2010 to 2014, two areas of the site were investigated and sampled for archaeobotanical finds and micro-debris in a high-resolution approach. This paper aims at 1) analysing the food plant spectrum at the mining settlement of Prigglitz-Gasteil basing on charred plant macroremains, 2) investigating producer/consumer aspects of Prigglitz-Gasteil in comparison to the Bronze Age metallurgical sites of Kiechlberg, Klinglberg, and Mauken, and 3) reconstructing the miners’ and metallurgists’ diets.Our analyses demonstrate that the plant-based diet of the investigated mining communities reflects the general regional and chronological trends rather than particular preferences of the miners or metallurgists. The lack of chaff, combined with a high occurrence of processed food, suggests that the miners at Prigglitz-Gasteil were supplied from outside with ready-to-cook and processed grain, either from adjacent communities or from a larger distance. This consumer character is in accordance with observation from previously analysed metallurgical sites. Interestingly, the components observed in charred cereal products (barley,Hordeum vulgare, and foxtail millet,Setaria italica) contrast with the dominant crop taxa (broomcorn millet,Panicum miliaceum, foxtail millet, and lentil,Lens culinaris). Foraging of fruits and nuts also significantly contributed to the daily diet.
Use of face masks to limit the spread of the COVID-19 among western Ugandans: Knowledge, attitude and practices
Authors: Sikakulya Franck Katembo , Ssebuufu Robinson , Mambo Simon Binezero , Pius Theophilus , Kabanyoro Annet , Kamahoro Elizabeth , Mulumba Yusuf , Muhongya Jean Kakule , Kyamanywa Patrick 
Published: March 2021

Background
The world is grappling with an ever-changing COVID-19 pandemic using preventive measures such as personal hygiene, face masks, restrictions on travel and gatherings in communities, in addition to a race to find a vaccine. The purpose of this study was to evaluate the knowledge, attitudes and practices of the western Uganda community on the proper use of face masks to mitigate the spread of COVID-19.

Methods
A cross-sectional study using a structured questionnaire was carried out from 1st July to 10th July 2020 among western Ugandans of consent age of 18 years and above. Data was analysed using Stata version 14.2.

Results
Among the respondents (n = 1114), the mean age was 30.7 (SD 11.1), 51% were males, 53.9% married and 43% had attained secondary education. Most participants (60.1%, n = 670) had satisfactory knowledge on the use of face masks and participants at a tertiary education level [AOR 2.6 (95% CI: 1.42–4.67; p = 0.002)] were likely to have satisfactory knowledge than participants who had not education. On attitude, most respondents (69.4%) were confident enough to correctly put on a face mask; 83.4% believed that a face mask can protect against COVID-19 and 75.9% of respondents had never shared their face mask. The majority of respondents (95.2%) agreed wearing face masks in public places was important to protect themselves against COVID-19; 60.3% reported washing their hands before wearing and after removing the face mask. Unfortunately, 51.5% reported removing the face mask if they needed to talk to someone.

Conclusion
Despite the satisfactory knowledge, good attitude and practices, there is still much more to be done in terms of knowledge, attitude and practices among participants. Government, non-governmental organizations and civil society should improve sensitization of populations on how to behave with face masks while talking to avoid the spread of the COVID-19 among western Ugandans.
Prevalence, risk factors and association with delivery outcome of curable sexually transmitted infections among pregnant women in Southern Ethiopia
Authors: Zenebe Mengistu Hailemariam , Mekonnen Zeleke , Loha Eskindir , Padalko Elizaveta 
Published: March 2021

IntroductionCurable sexually transmitted infections (STIs) such as infection withChlamydia trachomatis(C.trachomatis),Neisseria gonorrhoeae(N.gonorrhoeae), andTrichomonas vaginalis(T.vaginalis) can lead to adverse pregnancy and birth outcome. There are limited data on the prevalence and correlate of STI in Ethiopia, yet pregnant women are not screened for curable STI. Hence in this study, the prevalence of STIs and associated risk factors were assessed.MethodologyA cross- sectional study was conducted on consecutive women attending the delivery ward at the Hawassa comprehensive and specialized hospital. Vaginal swabs collected at the time of labor and delivery were tested forC.trachomatis,N.gonorrhoeaeandT.vaginalisusing GeneXpert. Study participants responded to a questionnaire about their previous and current obstetric history and socio-demographic characteristics. Possible independent factors for curable STIs were assessed by chi-square, bivariable, and multivariable, logistic regression.ResultsOf the 350 vaginal swabs tested, 51 (14.6%, 95% CI: 10.9–18.3) were positive for one or more curable STIs. The prevalence ofC.trachomatis,N.gonorrhoeaeandT.vaginaliswere 8.3%, 4.3%, and 3.1%, respectively. STIs was associated (p<0.005) with the delivery outcomes birth weight and gestational age. A 3-fold increase in odds of acquisition STIs was found in currently unmarried women (AOR, 3.5; 95% CI: 1.1–10.4; p = 0.028), in women <25 years (AOR, 2.7; 95% CI 1.1–6.6; p = 0.031). Women reporting presence of vaginal discharge (AOR, 7.7; 95% CI: 3.2–18.6; p < 0.001) and reporting pain during urination (AOR, 6.5; 95% CI: 2.6–16.2; p <0.001) found to associate with curable STIs.ConclusionThe higher magnitude of STIs found in this population, and the absence of symptoms in many illustrate the need for systematic follow-up during routine antenatal care primarily history taking and asking for signs and symptoms to provide early management and avoid long term sequelae.
Is the heart rate variability monitoring using the analgesia nociception index a predictor of illness severity and mortality in critically ill patients with COVID-19? A pilot study
Authors: Aragón-Benedí Cristian , Oliver-Forniés Pablo , Galluccio Felice , Yamak Altinpulluk Ece , Ergonenc Tolga , El Sayed Allam Abdallah , Salazar Carlos , Fajardo-Pérez Mario 
Published: March 2021

Introduction
The analysis of heart rate variability (HRV) has proven to be an important tool for the management of autonomous nerve system in both surgical and critically ill patients. We conducted this study to show the different spectral frequency and time domain parameters of HRV as a prospective predictor for critically ill patients, and in particular for COVID-19 patients who are on mechanical ventilation. The hypothesis is that most severely ill COVID-19 patients have a depletion of the sympathetic nervous system and a predominance of parasympathetic activity reflecting the remaining compensatory anti-inflammatory response.

Materials and methods
A single-center, prospective, observational pilot study which included COVID-19 patients admitted to the Surgical Intensive Care Unit was conducted. The normalized high-frequency component (HFnu), i.e. ANIm, and the standard deviation of RR intervals (SDNN), i.e. Energy, were recorded using the analgesia nociception index monitor (ANI). To estimate the severity and mortality we used the SOFA score and the date of discharge or date of death.

Results
A total of fourteen patients were finally included in the study. ANIm were higher in the non-survivor group (p = 0.003) and were correlated with higher IL-6 levels (p = 0.020). Energy was inversely correlated with SOFA (p = 0.039) and fewer survival days (p = 0.046). A limit value at 80 of ANIm, predicted mortalities with a sensitivity of 100% and specificity of 85.7%. In the case of Energy, a limit value of 0.41 ms predicted mortality with all predictive values of 71.4%.

Conclusion
A low autonomic nervous system activity, i.e. low SDNN or Energy, and a predominance of the parasympathetic system, i.e. low HFnu or ANIm, due to the sympathetic depletion in COVID-19 patients are associated with a worse prognosis, higher mortality, and higher IL-6 levels.
Planning deficits in Huntington’s disease: A brain structural correlation by voxel-based morphometry
Authors: Calderon-Villalon Jesus , Ramirez-Garcia Gabriel , Fernandez-Ruiz Juan , Sangri-Gil Fernanda , Campos-Romo Aurelio , Galvez Victor 
Published: March 2021

Introduction
Early Huntington’s disease (HD) patients begin to show planning deficits even before motor alterations start to manifest. Generally, planning ability is associated with the functioning of anterior brain areas such as the medial prefrontal cortex. However, early HD neuropathology involves significant atrophy in the occipital and parietal cortex, suggesting that more posterior regions could also be involved in these planning deficits.

Objective
To identify brain regions associated with planning deficits in HD patients at an early clinical stage.

Materials and methods
Twenty-two HD-subjects genetically confirmed with incipient clinical manifestation and twenty healthy subjects were recruited. All participants underwent MRI T1 image acquisition as well as testing in the Stockings of Cambridge (SOC) task to measure planning ability. First, group comparison of SOC measures were performed. Then, correlation voxel-based morphometry analyses were done between gray matter degeneration and SOC performance in the HD group.

Results
Accuracy and efficiency planning scores correlated with gray matter density in right lingual gyrus, middle temporal gyrus, anterior cingulate gyrus, and paracingulate gyrus.

Conclusions
Our results suggest that planning deficits exhibited by early HD-subjects are related to occipital and temporal cortical degeneration in addition to the frontal areas deterioration.
Metodología SLP para la distribución en planta de empresas productoras de Guadua Laminada Encolada (G.L.G)
Authors: Torres Kelly Jhoana , Florez Peña Laura Sofía , Sánchez Carlos William , Castañeda Peñaranda Mauricio 
Published: March 2021

Contexto: La guadua Angustifolia Kunth es una planta derivada del bambú, es un pasto leñoso que ha sido denominado el acero vegetal, gracias a las propiedades de flexibilidad, dureza y elasticidad que permite su uso a nivel industrial como un insumo para fabricar tablones de guadua laminada (Glue Laminated Guadua) que pueden ser usados para fabricar vigas y otros elementos estructurales requeridos por la arquitectura.
Metodo: En este caso se documento un diseño de distribución en planta mediante la metodología SLP (Systematic Layout Planning), tomando como caso de estudio la empresa Guadua Viga, en donde se caracterizó y se analizaron los procesos de la empresa, se definieron los requerimientos iniciales y se realizo el diseño de la distribucion en planta por ultimo se evaluaó la propuestas en terminos de costos
Resultados:se plantearon 3 propuestas de distribución en planta de acuerdo con las necesidades de la empresa y del proceso de produción de tableros de guadua laminada y se evaluaron las alternativas en terminos de eficiencias.
Conclusión: La alternativa que fue propuesta requiere de 4148 m2, cuenta con una eficiencia de 89% respecto al flujo de materiales, un 62% de eficiencia respecto al flujo de materiales y adyacencia.
Estudio Comparativo de Tres Estrategias de Control para la Regulaci´on de Frecuencia de una Micro Red en Operaci´on Aislada
Authors: Pineda Muñoz Edwin Alexis , Gauthier Selleir Alain 
Published: March 2021

Contexto: La reducci´on de combustibles f´osiles, la necesidad de disminuir las emisiones de di´oxido de carbono (CO2) en el planeta y el inter´es por garantizar una seguridad energ´etica ha incrementado la investigaci´on en la producci´on de energ´ıa el´ectrica utilizando fuentes de energ´ıas renovables incorporadas a micro redes ´o MGs (Microgrids). Este panorama presenta desaf´ıos t´ecnicos que deben ser cubiertos para garantizar niveles de confiabilidad adecuados.
M´etodo: Este estudio compara tres estrategias de control basadas en el control predictivo del modelo ´o MPC (Model Predictive Control), el control ´optimo LQ-Servo (Linear Quadratic Servo) y el control proporcional integral ´o PI, con el objetivo de regular la frecuencia frente a incertidumbres en la carga y perturbaciones ambientales, considerando un modelolineal aislado de microrred que incluye generadores convencionales y renovables, dispositivos de almacenamiento de energ´ıa y cargas.
Resultados: Las simulaciones de la micro red en operaci´on aislada, en presencia de perturbaciones de viento, carga y potencia solar, muestran un mejor desempe˜no bajo diferentes escenarios de los controladores MPC y LQ-Servo con respecto a las caracter´ısticas din´amicas que presenta la desviaci´on de frecuencia y la se˜nal de control.
Conclusiones: La estrategia de control ´optimo LQ-Servo, poco investigada en micro redes, se presenta como una opci´on viable a considerar en el dise˜no de controladores secundarios de micro redes en operaci´on aislada, debido a las caracter´ısticas de desempe˜no mostradas en la regulaci´on de frecuencia. Consideraci´on de modelos que incluyan restricciones en las variables de control y en los estados de la micro red, as´ı como la implementaci´on de los mismos, quedan como trabajo futuro.
Palabras clave: Funci´on costo, generaci´on renovable, optimizaci´on, perturbaci´on, sintonizaci´on.
Idioma: Espa˜nol.
The relationship between expression of VIMENTIN and CD146 genes in breast cancer
Authors: Kocemba-Pilarczyk Kinga A. , Dudzik Paulina , Leśkiewicz Katarzyna 
Published: March 2021

Abstract

Objectives
CD146 is an adhesive molecule that was originally reported on malignant melanoma cells as a protein crucial for cell adhesion. It is now known that high expression of the CD146 protein is not only characteristic of melanoma, but it occurs on a number of cancers, contributing to worse prognosis and increased aggressiveness. Independent in vitro studies in breast cancer have shown that CD146 protein alone can induce a change in epithelial to mesenchymal transcriptional profile, which is the basis of the tumor aggressiveness and metastasis.

Methods
In the following work, the correlation coefficients were analyzed between the genes of the mesenchymal profile and the CD146 gene in 10 independent transcriptomic data of breast cancer patients.

Results
The analysis confirmed the relationship between CD146 expression and mesenchymal profile genes, pointing VIMENTIN as the gene which expression is most strongly correlated with the CD146, suggesting that both genes, CD146 and VIM may be directly controlled by the same mechanism or regulate one another.

Conclusions
The analysis points a potential route for research on the CD146 gene expression, which may lead to understanding of its regulation in breast cancer, contributing to the development of new therapeutic strategies targeting highly metastatic breast cancer cells.
Diversity of microbiota in Slovak summer ewes’ cheese “Bryndza”
Authors: Kačániová Miroslava , Terentjeva Margarita , Kunová Simona , Haščík Peter , Kowalczewski Przemysław Łukasz , Štefániková Jana 
Published: March 2021

Abstract
“Bryndza” cheese is an important Slovak traditional regional product. New knowledge on the role of microorganisms involved the “Bryndza” ripening process may provide valuable data on its quality and safety. In our study, the “Bryndza” made from pasteurized ewes milk was studied towards total count of bacteria, coliforms bacteria, enterococci, lactic acid bacteria, and microscopic filamentous fungi. All those groups of microbiota were detected using classical microbiological methods and identified using mass spectrometry. A total of 3,758 isolates were identified with score higher than 2.00. Altogether, 13 families, 24 genus, and 44 species of microbiota were identified in Slovak cheese “Bryndza.” The most often isolated species were yeasts Yarrowia lipolitica and Dipodascus geotrichum and the lactic acid bacteria Lactobacillus paracasei subsp. paracasei.
Rare norisodinosterol derivatives from Xenia umbellata: Isolation and anti-proliferative activity
Authors: Bawakid Nahed Obaid , Alarif Walied Mohamed , Abdel-Lateff Ahmed 
Published: March 2021

Abstract
Two new rare 30-norisodinosterol derivatives, 23,24-dimethylcholest-16-ene-3β,5α,6β,11α,20(R)-pentol 3-monoacetate (1) and 23,24-dimethylcholest-16-ene-3β,5α,6β,20(R)-tertrol 3-monoacetate (2), along with a known steroid, 3β,5α,6β,11α,20β-pentahydroxygorgosterol (3), were identified from Xenia umbellata. The structures of the isolated compounds were determined by analyses of the measured spectra (1D and 2D nuclear magnetic resonance, mass spectrometry, and infrared). The biosynthetic pathway of the new norisodinosterols was proposed. Compound 1 exhibited potent cytotoxicity against HepG2, PC-3, and HT-29 with IC50 values of 4.70 ± 0.2, 5.60 ± 0.6, and 4.00 ± 0.4 μg/mL, respectively. On the contrary, compound 3 showed less potent cytotoxicity against HepG2 with IC50 value of 22.20 ± 1.0 μg/mL. Two DNA-binding dyes have been used for the morphological detection of viable, apoptotic, and necrotic cells. The early apoptotic cell death was observed in all types of treated tumour cells. The late apoptotic cells are highly present in HepG2 cells with compound 3 compared with other cancer cells except for compound 1. The anti-proliferative activity of compounds 1 and 3 warranted further investigation.
Changes in retention characteristics of 9historical artificial water reservoirs near BanskáŠtiavnica, Slovakia
Authors: Kubinský Daniel , Weis Karol , Fuska Jakub , Lehotský Milan , Petrovič František 
Published: March 2021

AbstractThe article is focused on the evaluation of accumulationvolume changes in 9 water reservoirs nearBanská Štiavnica (Slovakia) by comparing historical mapsand using modern bathymetric surveying technologies.The mining region of Banská Štiavnica has been inscribedinto the UNESCO List of the World and Cultural Heritagein 1993. Accumulation and transfer of sediments dependmainly on changes of land cover in the watersheds thatlead to the loss of retention capacity and reduction oflife span of reservoirs. The results of a comparison oftwo 3D models, one created from historic documentationand the other created from data of field surveying haveshown overall reduction in the volume of water totalling446484m3, i.e. 16.70%from past to current time. Causes ofsedimentation were searched in watersheds changes overtime. These were identified by comparison of historicalaerial imagery (1949) with existing aerial photographs.
Stability of an abandoned siderite mine: A case study in northern Spain
Authors: Trigueros Emilio , Cánovas Manuel , Arzúa Javier , Alcaraz Manuel 
Published: March 2021

Abstract
Bodovalle is an iron carbonate mine located in Gallarta (near Bilbao, northern Spain), which is currently in the closure stage. The deposit was first exploited as an open-pit mine and later as an underground mine. The underground mine currently has 40 large rooms with rib pillars, occupying an area of 2,000 m long by 600 m wide. Room depth is around 200 m. The main geotechnical incident occurred in the NW1N zone, where an over-exploited rib pillar in poor condition was partially removed, leaving a 70-m roof span that eventually collapsed in 1999, resulting in a surface crater measuring 60 m in diameter. The collapse was preceded by noises and movements detected outside the mine. The subsidence was improved by means of infilling and monitoring. In 2014, residents living in homes built over the abandoned mine rooms detected very loud noises similar to those of 1999. The article describes a stability review carried out using advanced numerical methods (finite element method and boundary element method) and the geomechanical parameters obtained from a back analysis of the 1999 collapse.
A novel meat quality improver composed of carrageenan and superfine smashed okra powder and its application in chicken meatballs
Authors: Liu Yan , Zhou Xi , Zhang Min , Zhou Ying , Fan Yaqi , Zhang Xingguo , Yu Xizhen , Xiong Guoyuan , Li Jingjun 
Published: March 2021

Abstract
The study investigated the effects of the addition of 0% (control group, CG), 0.25, 0.35, and 0.45% superfine smashed okra powder (SSOP) or carrageenan (CAR), and 0.25% SSOP – 0.35% CAR complex (OC) on the quality of chicken meatballs. Chicken meatballs fabricated with the SSOP-CAR complex showed better quality as compared to the other treatments. The lowest cooking loss was observed in the OC group, which corresponded to significantly decreased relaxation times of low-field nuclear magnetic resonance (LF-NMR) (T
21 and T
22) (P < 0.05). Compared to CG, The L* and a* values of chicken meatballs were significantly decreased due to the addition of SSOP (P < 0.05), and the additions of SSOP and CAR significantly increased the storage modulus (G′) and loss modulus of chicken meat batter upon heating (P < 0.05). Besides, the OC and 0.45% CAR groups showed the highest texture profile values for hardness and chewiness (P < 0.05). The sensory evaluation revealed that the chicken meatballs emulsified with the OC had the best overall acceptability. The results indicated that OC could be a great feasible and potential application in the meat industry, especially in the development of functional emulsified meat products.
Recurrence relations for a family of iterations assuming Hölder continuous second order Fréchet derivative
Authors: Gupta Dharmendra Kumar , Martínez Eulalia , Singh Sukhjit , Hueso Jose Luis , Srivastava Shwetabh , Kumar Abhimanyu 
Published: March 2021

Abstract
The semilocal convergence using recurrence relations of a family of iterations for solving nonlinear equations in Banach spaces is established. It is done under the assumption that the second order Fréchet derivative satisfies the Hölder continuity condition. This condition is more general than the usual Lipschitz continuity condition used for this purpose. Examples can be given for which the Lipschitz continuity condition fails but the Hölder continuity condition works on the second order Fréchet derivative. Recurrence relations based on three parameters are derived. A theorem for existence and uniqueness along with the error bounds for the solution is provided. The R-order of convergence is shown to be equal to 3 + q when θ = ±1; otherwise it is 2 + q, where q ∈ (0, 1]. Numerical examples involving nonlinear integral equations and boundary value problems are solved and improved convergence balls are found for them. Finally, the dynamical study of the family of iterations is also carried out.