bluuebunny/crossref_metadata_2025_split huggingface dataset:
A risk scoring system for seafood supply chain breaches and examination of freshwater fish imported to Australia
Authors: Williams Michelle , Hernandez-Jover Marta , Williams Thomas , Shamsi Shokoofeh 
Published: June 2021

Abstract
Legislative changes have altered the way imported edible seafood is inspected in Australia. Greater onus of responsibility has been placed on exporting countries to provide documentary evidence of adherence to internally recognized food safety standards. According to global trade agreements, any additional safety tests applied to freshwater fish imported into Australia must be justified. Therefore, the aim of this study was to develop a risk scoring method to provide justification for identifying countries as ‘Freshwater fish high risk’ and to examine the seafood they export to Australia for seafood supply chain breaches. Scoring was conducted using six predictor variables, identified in the literature as important contributors to seafood supply chain breaches, to achieve the outcome variable, Country considered ‘Freshwater fish high risk’. Sixty-seven fish fillets (9.55 kg) of the same species were examined from the third highest scoring country (Country 20) and 562 (5.6 kg) whole fish from the sixth highest scoring country (Country 22). Country 20 had supply chain breaches of 28 macroscopic yellow cysts in one fillet. Two hundred and thirteen parasites and other supply chain breaches were identified in fish from Country 22, including retained liver (91 per cent), visible mud (11 per cent), a variety of debris (16 per cent) and, depending on the commodity code, these fish were imported to Australia under full intestine (90 per cent), retained gills (89 per cent), and partial intestine (9 per cent). Three serious physical hazards were recovered from the edible portion of three ‘consumer-ready’ fish and snails of Genus Lymnaea and Indoplanorbis were recovered from gill mud also from ‘consumer-ready’ fish. The study showed variable results from the scoring system and vast differences in seafood supply chain breaches between the third and sixth highest scoring countries.
Comparing the clinical application values of the Degree of Ulcerative Colitis Burden of Luminal Inflammation (DUBLIN) score and Ulcerative Colitis Endoscopic Index of Severity (UCEIS) in patients with ulcerative colitis
Authors: Zhang Xiao-Fei , Li Peng , Ding Xue-Li , Chen Hao , Wang Shao-Jun , Jin Sheng-Bo , Guo Jing , Tian Zi-Bin 
Published: June 2021

AbstractBackgroundThe significance of endoscopic evaluation in the diagnosis and management of ulcerative colitis (UC) has been widely recognized. Over the years, scholars have established several endoscopic scores. Herein, we assessed the clinical application value of the Mayo Endoscopic Subscore (Mayo ES), the Degree of Ulcerative Colitis Burden of Luminal Inflammation (DUBLIN) score, and the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) score in UC patients, by comparing their correlation with disease activity and their predictive potential for treatment response and clinical outcomes.MethodsUC patients hospitalized from September 2015 to September 2019 were retrospectively analysed. We employed Spearman's rank correlation coefficient to assess the linear association of the assessed endoscopic scores with the clinical parameters. The receiver-operating characteristic curve was applied to evaluate the predictive capabilities of the endoscopic scores for treatment escalation and 1-year readmission.ResultsA total of 178 patients were enrolled; most of them (82%) suffered moderate or severe colitis. Among them, 48 (27%) patients received treatment escalation and 59 (33%) were readmitted within 1 year. The DUBLIN and UCEIS scores demonstrated higher correlations with clinical parameters than the Mayo ES. The DUBLIN scores significantly differed between patients with mild, moderate, and severe colitis (all P &lt; 0.001). The UCEIS scores demonstrated the best predictabilities for treatment escalation and 1-year readmission with an area under the curve of 0.88 and 0.75, respectively. Compared to the UCEIS and DUBLIN scores, the predictive capabilities of the Mayo ES for treatment escalation (both P &lt; 0.001) and 1-year readmission (P &lt; 0.001 and P = 0.002, respectively) were lower. The UCEIS scores exhibited a significant difference between the steroid-responsive group and the steroid-dependent or steroid-refractory group (both P &lt; 0.001), while no significant differences in the Mayo ES and DUBLIN scores were found among the three groups (both P &gt; 0.05).ConclusionThis study demonstrates that both the DUBLIN and UCEIS scores outperform the Mayo ES in assessing disease severity and predicting treatment response and clinical outcomes in UC patients.
Conservation of a DNA Replication Motif among Phylogenetically Distant Budding Yeast Species
Authors: Maria Haniam , Kapoor Shivali , Liu Tao , Rusche Laura N 
Published: June 2021

Abstract
Eukaryotic DNA replication begins at genomic loci termed origins, which are bound by the origin recognition complex (ORC). Although ORC is conserved across species, the sequence composition of origins is more varied. In the budding yeast Saccharomyces cerevisiae, the ORC-binding motif consists of an A/T-rich 17 bp “extended ACS” sequence adjacent to a B1 element composed of two 3-bp motifs. Similar sequences occur at origins in closely related species, but it is not clear when this type of replication origin arose and whether it predated a whole-genome duplication that occurred around 100 Ma in the budding yeast lineage. To address these questions, we identified the ORC-binding sequences in the nonduplicated species Torulaspora delbrueckii. We used chromatin immunoprecipitation followed by sequencing and identified 190 ORC-binding sites distributed across the eight T. delbrueckii chromosomes. Using these sites, we identified an ORC-binding motif that is nearly identical to the known motif in S. cerevisiae. We also found that the T. delbrueckii ORC-binding sites function as origins in T. delbrueckii when cloned onto a plasmid and that the motif is required for plasmid replication. Finally, we compared an S. cerevisiae origin with two T. delbrueckii ORC-binding sites and found that they conferred similar stabilities to a plasmid. These results reveal that the ORC-binding motif arose prior to the whole-genome duplication and has been maintained for over 100 Myr.
Revisiting the notion of deleterious sweeps
Authors: Johri Parul , Charlesworth Brian , Howell Emma K , Lynch Michael , Jensen Jeffrey D 
Published: June 2021

Abstract
It has previously been shown that, conditional on its fixation, the time to fixation of a semi-dominant deleterious autosomal mutation in a randomly mating population is the same as that of an advantageous mutation. This result implies that deleterious mutations could generate selective sweep-like effects. Although their fixation probabilities greatly differ, the much larger input of deleterious relative to beneficial mutations suggests that this phenomenon could be important. We here examine how the fixation of mildly deleterious mutations affects levels and patterns of polymorphism at linked sites—both in the presence and absence of interference amongst deleterious mutations—and how this class of sites may contribute to divergence between-populations and species. We find that, while deleterious fixations are unlikely to represent a significant proportion of outliers in polymorphism-based genomic scans within populations, minor shifts in the frequencies of deleterious mutations can influence the proportions of private variants and the value of FST after a recent population split. As sites subject to deleterious mutations are necessarily found in functional genomic regions, interpretations in terms of recurrent positive selection may require reconsideration.
Associations of Word Memory, Verbal Fluency, Processing Speed, and Crystallized Cognitive Ability With One-Legged Balance Performance in Mid- and Later Life
Authors: Blodgett Joanna M , Cooper Rachel , Davis Daniel H J , Kuh Diana , Hardy Rebecca 
Published: June 2021

Abstract

Background
Cognitive integration of sensory input and motor output plays an important role in balance. Despite this, it is not clear if specific cognitive processes are associated with balance and how these associations change with age. We examined longitudinal associations of word memory, verbal fluency, search speed, and reading ability with repeated measures of one-legged balance performance.

Method
Up to 2 934 participants in the MRC National Survey of Health and Development, a British birth cohort study, were included. At age 53, word memory, verbal fluency, search speed, and reading ability were assessed. One-legged balance times (eyes closed) were measured at ages 53, 60–64, and 69 years. Associations between each cognitive measure and balance time were assessed using random-effects models. Adjustments were made for sex, death, attrition, height, body mass index, health conditions, health behaviors, education, and occupational class.

Results
In sex-adjusted models, 1 SD higher scores in word memory, search speed, and verbal fluency were associated with 14.1% (95% CI: 11.3, 16.8), 7.2% (4.4, 9.9), and 10.3% (7.5, 13.0) better balance times at age 53, respectively. Higher reading scores were associated with better balance, although this association plateaued. Associations were partially attenuated in mutually adjusted models and effect sizes were smaller at ages 60–64 and 69. In fully adjusted models, associations were largely explained by education, although remained for word memory and search speed.

Conclusions
Higher cognitive performance across all measures was independently associated with better balance performance in midlife. Identification of individual cognitive mechanisms involved in balance could lead to opportunities for targeted interventions in midlife.
Vigorous Physical Activity and Cognitive Trajectory Later in Life: Prospective Association and Interaction by Apolipoprotein E e4 in the Nurses’ Health Study
Authors: Fassier Philippine , Kang Jae Hee , Lee I-Min , Grodstein Francine , Vercambre Marie-Noël 
Published: June 2021

Abstract

Background
The apolipoprotein E (APOE) e4 allele is a well-established genetic risk factor of brain aging. Vigorous physical activity may be particularly important in APOE-e4 carriers, but data have been inconsistent, likely due to differences in the timing of the physical activity assessment, definition of cognitive decline, and/or sample size.

Methods
We prospectively evaluated the association between vigorous physical activity and cognition assessed at least 9 years later, according to APOE-e4 carrier status. Biennially from 1986, Nurses’ Health Study participants reported their leisure-time physical activities. Starting in 1995–2001 and through 2008, participants (aged 70+ years) underwent up to 4 repeated cognitive telephone assessments (6 tasks averaged together using z-scores).

Results
Among 7252 women, latent process mixed models identified 3 major patterns of cognitive change over 6 years: high-stable, medium-stable, and decline. Taking the high-stable cognitive trajectory as the outcome reference in multinomial logistic regressions, highest tertile of vigorous physical activity (≥5.9 metabolic-equivalent [MET]-hours/wk) compared to lowest tertile (≤0.9 MET-hours/wk) was significantly associated with subsequent lower likelihood of the medium-stable trajectory in the global score (odds ratio [OR] [95% CI] = 0.72 [0.63, 0.82]), verbal memory (OR [95% CI] = 0.78 [0.68–0.89]), and telephone interview of cognitive status score (OR [95% CI] = 0.81 [0.70–0.94]). Vigorous physical activity was also associated with lower likelihood of decline in category fluency (OR [95% CI] = 0.72 [0.56, 0.92]). We observed some evidence (p-interaction = .07 for the global score) that the association was stronger among APOE-e4 carriers than noncarriers (OR [95% CI] = 0.60 [0.39, 0.92] vs 0.82 [0.59, 1.16]).

Conclusion
Midlife vigorous physical activity was associated with better cognitive trajectories in women in their seventies, with suggestions of stronger associations among APOE-e4 carriers.
Perceived Discrimination, Nativity, and Cognitive Performance in a Multiethnic Study of Older Adults: Findings From the Kaiser Healthy Aging and Diverse Life Experiences Study
Authors: Meza Erika , Peterson Rachel , Gilsanz Paola , George Kristen M , Miles Sunita J , Eng Chloe W , Mungas Dan M , Mayeda Elizabeth Rose , Glymour M Maria , Whitmer Rachel A 
Published: June 2021

Abstract

Background
Despite growing research on the association between discrimination and disparities in cognitive aging, an evidence gap remains on how the association varies by racial/ethnic group. This study evaluates the associations of experiences of discrimination with cognitive function and whether these associations varied by race/ethnicity and nativity.

Method
Using the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) cohort (N = 1 712) with approximately equal groups of Black, White, Latino, and Asian community-dwelling older adults aged 65 years and older, we evaluated the associations between self-reported experiences of everyday and major lifetime discrimination with overall cognitive performance and domain-specific cognition (verbal episodic memory, semantic memory, and executive functioning) across race/ethnicity and nativity. Linear regression models examined the cross-sectional association between self-reported experiences of everyday and major lifetime discrimination with z-standardized coefficients for cognition. We tested for effect modification by race and nativity. All models controlled for age, sex, and education.

Results
Among KHANDLE participants (mean age: 76 years; SD: 6.8), everyday discrimination was not associated with cognitive scores. Major lifetime discrimination was associated with better average cognitive scores among Black participants but not among other racial/ethnic groups. Major lifetime discrimination was associated with better average cognitive scores among U.S.-born but not among non-U.S.-born individuals.

Conclusion
Our findings do not imply that discrimination improves cognition, but rather suggest that future research should include more detailed measures on discrimination and unfair treatment that could help disentangle the extent to which relationships are causal or reflect some other underlying factor.
The ocean pole tide loading and its effect on GPS position time-series
Authors: Niu Yujiao , Li Min , Wei Na , Shi Chuang , Chen Guo , Wang Lin 
Published: June 2021

SUMMARYThe changes in the centrifugal force induced by polar motion perturb the ocean, causing an ocean pole tide. The induced displacements due to the ocean pole tide, namely ocean pole tide loading (OPTL), previously ignored, raises the concerns in the GPS data processing with the increasing accuracy of Global Position System (GPS) technique. Though the amplitude of this effect is small, it is worth to demonstrate the magnitude and its impact on GPS solutions of the processing choices for correcting it from observations or onto estimated coordinates. For OPTL modelling, subdaily polar motion can introduce annual variations in OPTL with the small magnitudes in micrometres. The new secular pole model can cause OPTL vertical velocity difference up to 0.03 mm yr−1 compared with the mean pole model of International Earth Rotation and Reference System Service Conventions (2010). The OPTL deformation is dominated by the annual (∼365.25 d) and Chandler (∼433 d) periods, and the largest peak-to-peak variations can reach 0.70, 0.84 and 2.38 mm for East, North and Up components, respectively. We then investigate the effects of OPTL correction on GPS daily positions of 133 stations from 2014 to 2018. The root mean square of OPTL induced GPS daily displacements can reach submillimetre level. In most cases, a posteriori OPTL correction with daily averaged values applied onto the coordinates is acceptable considering the small deviation between the solution removing OPTL from coordinates and the solution correcting OPTL from observations. However, this does not hold when GPS coordinates have been aligned to a secular reference frame, as the annual/Chandler variations of OPTL would be biased. When reference frame alignment is required, either OPTL correction at observation level or a posteriori OPTL correction before reference frame alignment is recommended. Furthermore, we have demonstrated that the effects of OPTL on the annual variations of GPS position time-series can reach as much as 0.4 mm in the verticals. It has limited effect on the linear velocity and reduction of the residuals scatter (annual variations excluded), within Global Geodetic Observing System requirements for the future terrestrial reference frame at millimetre level.
The Curse of the Original: How and When Heritage Branding Reduces Consumer Evaluations of Enhanced Products
Authors: Han Minju , Newman George E , Smith Rosanna K , Dhar Ravi 
Published: June 2021

Abstract
Heritage branding is a common marketing strategy that has been shown to increase product appeal. Here, we find that certain forms of heritage branding can also have potentially negative consequences by leading consumers to react negatively to changes made to the brand’s original, flagship product—even if those changes objectively improve it. We demonstrate that when firms engage in heritage branding that emphasizes a brand’s longevity, consumers evaluate enhanced products less favorably than the original versions of those same products due to decreased perceptions of continuity authenticity. We demonstrate this effect across a variety of product domains (e.g., cosmetics, cookware, and food products), using online experiments as well as in-person product trials. Moreover, we provide a framework that distinguishes between types of heritage branding cues that lead to negative evaluations of enhanced products versus those that do not. Finally, beyond identifying an important boundary condition based on specific aspects of heritage branding, we further show how the negative evaluations of enhanced products can be attenuated if brands reframe product changes as continuous with the brand’s origins. Together, these studies contribute to existing theory regarding heritage branding and authenticity, while also providing a number of practical recommendations for heritage brands.
Biology and Management of Eriophyid Mites in Turfgrass
Authors: Brown Matthew S , Blubaugh Carmen K , Chong Juang Horng 
Published: June 2021

Abstract
Eriophyid mites (Acari: Eriophyidae) are challenging to manage in turfgrass because their small size hinders visual detection, and conventional management approaches are not consistently effective. They induce growth distortions, which lead to poor stolon and root development and eventual plant death. Aceria cynodoniensis Sayed and Aceria slykhuisi Hall live beneath leaf sheaths, and cause crowded and stunted leaves, and bunched shoot proliferation. Aceria zoysiae (Baker, Kono, & O’Neill) and Aceria cynodonis Wilson live on exposed plant surfaces and cause twisted leaf tips to get caught in folded, older leaves, producing an arched terminal leaf. Because eriophyid mites are challenging to see directly, scouting utilizes the above symptoms but not as indicators of mite abundance. Mite-induced injuries can ruin the appearance of turf on golf course fairways with high aesthetic standards. Mite infestation weakens the turf, which slows down recovery from wear on golf courses and athletic fields and leads to production losses on sod farms when the sod breaks during harvest. Available miticides are ineffective to marginally effective. For this reason, cultural control options, such as reduced fertilizer application or scalping, form the cornerstone of a management program where chemical control is complementary. Currently, incomplete ecological knowledge about turfgrass-infesting eriophyid mites hinders the development of an effective integrated management program. Better information about plant–mite interactions could provide insight that leads to developing management tactics that promote resistance and control of these enigmatic pests. This review summarizes current knowledge on life history, ecology, and management strategies for turfgrass-infesting eriophyid mites.
Harnessing translational research in wheat for climate resilience
Authors: Reynolds Matthew P , Lewis Janet M , Ammar Karim , Basnet Bhoja R , Crespo-Herrera Leonardo , Crossa José , Dhugga Kanwarpal S , Dreisigacker Susanne , Juliana Philomin , Karwat Hannes , Kishii Masahiro , Krause Margaret R , Langridge Peter , Lashkari Azam , Mondal Suchismita , Payne Thomas , Pequeno Diego , Pinto Francisco , Sansaloni Carolina , Schulthess Urs , Singh Ravi P , Sonder Kai , Sukumaran Sivakumar , Xiong Wei , Braun Hans J 
Published: June 2021

AbstractDespite being the world’s most widely grown crop, research investments in wheat (Triticum aestivum and Triticum durum) fall behind those in other staple crops. Current yield gains will not meet 2050 needs, and climate stresses compound this challenge. However, there is good evidence that heat and drought resilience can be boosted through translating promising ideas into novel breeding technologies using powerful new tools in genetics and remote sensing, for example. Such technologies can also be applied to identify climate resilience traits from among the vast and largely untapped reserve of wheat genetic resources in collections worldwide. This review describes multi-pronged research opportunities at the focus of the Heat and Drought Wheat Improvement Consortium (coordinated by CIMMYT), which together create a pipeline to boost heat and drought resilience, specifically: improving crop design targets using big data approaches; developing phenomic tools for field-based screening and research; applying genomic technologies to elucidate the bases of climate resilience traits; and applying these outputs in developing next-generation breeding methods. The global impact of these outputs will be validated through the International Wheat Improvement Network, a global germplasm development and testing system that contributes key productivity traits to approximately half of the global wheat-growing area.
Synthesis of the first nitrogen-heterocycles in interstellar ice analogues containing methylamine (CH3NH2) exposed to UV radiation: formation of trimethylentriamine (TMT, c-(-CH2-NH)3) and hexamethylentetramine (HMT, (CH2)6N4)
Authors: Carrascosa H , González Díaz C , Muñoz Caro G M , Gómez P C , Sanz M L 
Published: June 2021

ABSTRACT
Hexamethylentetramine has drawn a lot of attention due to its potential to produce prebiotic species. This work aims to gain a better understanding in the chemical processes concerning methylamine under astrophysically relevant conditions. In particular, this work deeps into the formation of N-heterocycles in interstellar ice analogues exposed to UV radiation, which may lead to the formation of prebiotic species. Experimental simulations of interstellar ice analogues were carried out in ISAC. ISAC is an ultrahigh vacuum chamber equipped with a cryostat, where gas and vapour species are frozen forming ice samples. Infrared and ultraviolet spectroscopy were used to monitor the solid phase, and quadrupole mass spectrometry served to measure the composition of the gas phase. The variety of species detected after UV irradiation of ices containing methylamine revealed the presence of 12 species which have been already detected in the ISM, being 4 of them typically classified as complex organic molecules: formamide (HCONH2), methyl cyanide (CH3CN), CH3NH and CH3CHNH. Warming up of the irradiated CH3NH2-bearing ice samples lead to the formation of trimethylentriamine (TMT), a N-heterocycle precursor of HMT, and the subsequent synthesis of HMT at temperatures above 230 K.