bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of cosmological values in the spatial order of public buildings in Kampong Naga, West Java
Authors: Safitri R , Purisari R , Mashudi M 
Published: June 2021

Abstract
Kampong Naga is one of the traditional villages in Indonesia that still preserves the environment and tradition naturally, while many traditional villages in Indonesia have been eroded by time and lost its original architectural forms that respond to nature and their beliefs. Kampong Naga, located in Tasikmalaya, West Java, is an embodiment of environmental and vernacular architectural arrangements that have been built and maintained for generations by the people. One of the powerful features of vernacular architecture is the existence of cosmological values in their landscapes and layout, both macro (village area) and micro (house). This study uses qualitative methods by processing primary and secondary data to identify Kampong Naga’s public buildings’ cosmological values such as the Mosque, Balai Adat, Public Baths, and Rice Mill based on the cosmos, castes, cultural customs, shapes, ornament, and the spatial order.
Redefining the concept of Tri Mandala cosmology in the spatial organization of resort hotel in Bali
Authors: Widyapuspita N , Hartanti N B , Rahma N 
Published: June 2021

Abstract
Protecting local culture is one of the sustainable development principles. Balinese Architecture is an embodiment of the cosmological Balinese Hindu concept, which is the local community’s way of life so that it needs to be preserved. The application of the Tri Mandala concept in modern building design through the neo vernacular architecture approach is a way to preserve Balinese culture. This paper is an exploration of the implementation of the cosmological traditional concept of Tri Mandala in the spatial organization of a modern resort hotel without changing its true meaning. The approach used is trough defining the traditional meaning of Tri Mandala and interpretation into the modern function context in resort hotel design in Kuta Bali. As a result, Tri Mandala divides space into three parts, namely Utama, Madya, Nista which means sacred, neutral, less sacred is realized in the zoning organization of private as unit rooms, public area as lobby, restaurant, drop off, and service area as kitchen and parking lot.
Vegetation of Keraton Cirebon as symbolize a cultural Cirebon
Authors: Rosmalia D , Damayanti S , Parutama A , Pribadi A W 
Published: June 2021

Abstract
Vegetation is not only an element of place in the landscape but also can improve a sacred value to a place. There are three Keraton in Cirebon City are known as a sacred place. one of the markers of the sacredness of the palace is the existence of sacred plants. Keraton is a residence of the sultan, who is considered as a messenger of God to this world, and vegetation in it functioned to increase the sacredness of it. The purpose of this study is to find the plant kind be a symbol of the Keraton which contains meaning that increases the sacred value of the Keraton, and also to find the physical function of the vegetation to the Keraton environment. The method used is qualitative analysis. The results study showed there are nine kinds of sacred plants, four of which had the highest level of sacredness can be a symbol of sacredness of Keraton. Besides, this research finding can be a guideline for the conservation activities of the Archipelagos plant.
Trend-seasonal components identification at the stage of time series pre-forecasting analysis
Authors: Savinskaya D N , Popova E V , Kondratev V U , Popova M I 
Published: June 2021

Abstract
This article contains the economic processes trend-seasonality identification and its analysis. The object of research is the water delivery market - HOD (Home & Office Delivery). The subject of the study is the drinking mineral water sales time series (TS) in the Krasnodar Territory in 19-liter PET bottles. The authors applied the Chetverikov’s iterative filtering method to the time series, implemented in the MS Excel environment. As the work result a step-by-step illustration of the filtering application to time series is presented, deviations are estimated, trend and the wave intensity coefficient are given. The practical significance of the study is that the characteristics obtained are the basis for subsequent effective forecasting.
The working body of the flat-cutter of the subsoiler-fertilizer
Authors: Novikov A E , Motorin V A 
Published: June 2021

Abstract
The article discusses issues related to the cultivation of agricultural crops with the simultaneous intrasoil application of mineral fertilizers. The size of the crop depends not only on the amount of fertilizers applied, but also on the quality of their application. Uneven fertilization leads both to a decrease in the biological yield and to inevitable losses during mechanized harvesting, due to the uneven structure of crops and different periods of plant ripening. An original design of a flat-cutter-subsoiler-fertilizer is proposed, the use of which will improve the quality of soil cultivation and crops, as well as the efficiency of intrasoil fertilization.
Sorghum harvester work quality assessment
Authors: Ryadnov A I , Fedorova O A , Sharipov R V , Baril V A 
Published: June 2021

Abstract
The article presents the results of experimental research on the sorghum harvester, equipped with a threshing-separating device of the inertial-combing type for harvesting Donskoe-35 variety broom sorghum, work quality in the conditions of farms in the south-western zone of the Volgograd region of Russia. The heads losses change (Qm) dependences on the combine speed (Vk) were determined: before the threshing chamber Qm = – 0.079Vk
2 + 0.426Vk + 0.01, behind the header Qm = – 0.133Vk
3 + 1.2Vk
2 – 3.567Vk + 4.1 and after the threshing chamber Qm = 0.057Vk
2 – 0.321Vk + 1.046, as well as grain losses (Qz): behind the normalizer Qz = 0,03Vk
3 – 0,241Vk
2 + 0,686Vk – 0,083, by the Qz = 0,004Vk
2 + 0,025Vk + 0,28 and under-threshing in a head Qz = 0,033Vk
2 – 0,032Vk + 0,204. The sorghum harvester threshing growing heads by a threshing-separating device of an inertial-combing type showed a high quality of work: an increased level of heads losses was observed behind the header at combine speeds up to 1.5 m/s, but they did not exceed 2.6% at a combine speed of 0.5 m/s; while studying types of grain losses, the losses behind the normalizer reached the level of 0.6% at a combine speed of 3.0 m/s; the loss of grain behind the thresher and under-threshing in the head did not exceed 0.4%.
Vegetative indices dynamics modeling based on multispectral distant monitoring data analysis
Authors: Tokarev K E 
Published: June 2021

Abstract
The article deals with the problems of monitoring the dynamics of vegetation indices on the basis of multispectral data obtained using technical means of remote monitoring. The effectiveness and validity of the application of vegetation indices was proved by comparing the values of plant indices with reference measurements at test sites of various types of plantings. A review of foreign sources and the results of statistical analysis allowed us to conclude that there is a non-linear relationship between productivity indices and crop yields.
Convolutional neural network of deep learning in computer vision and image classification problems
Authors: Tokarev K E , Zotov V M , Khavronina V N , Rodionova O V 
Published: June 2021

Abstract
The article considers the possibilities of using the deep learning convolutional neural network ResNet in computer vision and image classification problems. The interpretation of the ResNet network and the datasets used for its training are presented, as well as a method for training a deep convolutional neural network with stochastic depth, which allows significantly reducing errors in the test sample.
Metrology applications using off-axis digital holography microscopy
Authors: Emery Yves , Colomb Tristan , Cuche Etienne 
Published: June 2021

Abstract
Off-axis digital holography microscopy (DHM) systems have evolved during these last two decades from research to commercial instrumentation. They are used in many research laboratories and production facilities as metrology instruments in a large variety of applications including dimensional, surface topography, birefringence, oxide patterns thickness, and vibration characterization. The unique non-scanning quasi-instantaneous acquisition specificity of DHM opens new 4D metrology possibilities for observation of non-static scenes, operation in noisy environments, high throughput screening, and for providing fast feedback during manufacturing processes using artificial intelligence for decision making. These aspects are discussed and illustrated in this paper with the presentation of several applications to technical samples.
Associations Between Peripheral Blood Microbiome and the Risk of Hypertension
Authors: Jing Yang , Zhou Hui , Lu Honghong , Chen Xiaofang , Zhou Liangyue , Zhang Jingqi , Wu Jing , Dong Chen 
Published: June 2021

Abstract

Background
Although previous studies have reported the gut microbiome is closely related to hypertension development, whether the change in blood microbiome is associated with the risk of hypertension remains unclear.

Methods
One hundred and fifty incident hypertension cases and 150 age (± 2 years) and gender (1:1) matched nonhypertension controls included in this nested case–control study were recruited from a prospective cohort study of “135.” The composition of the blood microbiome was characterized using bacterial 16S ribosomal RNA gene sequencing. The relative abundance of detected bacteria was converted to a negative logarithm of 10 for the statistical analysis.

Results
Totally, 10,689,961 high-quality sequences were acquired. The Chao1 index of the blood microbiome in nonhypertension controls was significantly higher than in hypertensive group (2,302.08 ± 752.78 vs. 1,598.21 ± 500.88, P &lt; 0.001). Compared with the nonhypertension controls, the relative abundance of Proteobacteria phylum was significantly increased (P &lt; 0.001), whereas the relative abundance of phyla Firmicutes and Bacteroidetes were significantly reduced in the hypertensive cases (P &lt; 0.001 and P = 0.039, respectively). At genus level, the risk of hypertension was directly associated with the relative abundance of Acinetobacter (odds ratio [OR]: 1.43, 95% confidence interval [CI]: 1.01–2.03), Sphingomonas (OR: 1.84, 95% CI: 1.32–2.56), and Staphylococcus (OR: 0.51, 95% CI: 0.36–0.73), respectively. In addition, the relative abundance of Pseudomonas was minor positively correlated with the total cholesterol level. However, the relative Staphylococcus level was minor positively correlated with high-density lipoprotein cholesterol level.

Conclusions
The composition of the blood microbiome is significantly associated with the development of hypertension.
Transition from IV epoprostenol to oral treprostinil in a patient with group 1 pulmonary arterial hypertension
Authors: Sarangarm Preeyaporn , Elwood Kirsten 
Published: June 2021

Abstract

Purpose
Epoprostenol and treprostinil are prostacyclins indicated for the treatment of pulmonary arterial hypertension (PAH). Although there is literature describing the conversion of intravenous (IV) epoprostenol to IV treprostinil or IV treprostinil to oral treprostinil, there is little data on the direct conversion of IV epoprostenol to oral treprostinil. In this case, we describe the direct conversion of IV epoprostenol to oral treprostinil without an intermediary conversion to IV treprostinil.

Summary
A 39 year-old female with PAH was admitted for altered mental status and self-removal of her peripherally inserted central catheter (PICC) used for IV epoprostenol. Given the unplanned hospitalization, absence of a dedicated central line for IV prostacyclin therapy, and concern the patient may remove a future subcutaneous line, the patient was transitioned to oral treprostinil. Of note, despite triple PAH therapy, the patient was unable to reach a low risk group based on her prognostic risk assessment. A right heart catheterization four months prior found severe PAH with a pulmonary arterial pressure of 79/32 mmHg (mean, 49 mmHg) and pulmonary vascular resistance of 10.6 Wood units. To expedite the transition, the patient was directly converted from IV epoprostenol to oral treprostinil without an intermediary conversion to IV treprostinil. A target oral treprostinil dose of 5 mg TID was calculated based on 110% of the IV epoprostenol dose (19 ng/kg/min) utilizing the conversion recommended by the medication manufacturer. Every 8 hours, IV epoprostenol was decreased by 2 ng/kg/min and oral treprostinil was increased by 0.5 mg. The target oral treprostinil dose of 5 mg TID was reached 72 hours after conversion initiation. Three hours after the final titration, the patient was discharged home on room air.

Conclusion
In this case, rapid transition from IV epoprostenol to oral treprostinil was achieved in 72 hours without reported adverse effects.
Fatigue, Stress, and Performance during Alternating Physical and Cognitive Tasks—Effects of the Temporal Pattern of Alternations
Authors: Mixter Susanna , Mathiassen Svend Erik , Bjärntoft Sofie , Lindfors Petra , Lyskov Eugene , Hallman David M 
Published: June 2021

Abstract
In occupational life, performing cognitive work tasks in between fatiguing physical work tasks may allow recovery and reduce stress without losing productive working time. The temporal pattern of such alternations is likely a determinant of the recovery effect, influencing both stress and fatigue; the difficulty of the cognitive task (CT) would also be a likely determinant. The aim of this study was to determine to what extent the temporal pattern of alternations between a repetitive physical task and a CT of different difficulties influenced perceived fatigability, performance fatigability, stress-related outcomes, and performance. Fifteen women performed four work sessions comprising 110 min of repeated bouts of a repetitive physical task (pipetting), alternating with a CT (n-back). Sessions differed in bout cycle time (short: 7 + 3 min versus long: 14 + 6 min) and CT difficulty (CTdiff; easy versus difficult). Fatigue was assessed from recordings of maximal voluntary contraction force in shoulder elevations and handgrip pre- and post-work, electromyography (EMG) from the right trapezius and right forearm extensors during work, and repeated self-ratings of fatigue and pain throughout the session. Stress was assessed using electrocardiography (heart rate variability), salivary alpha-amylase, and self-reports. Perceived fatigue increased significantly over time for all protocols and more in long-cycle than short-cycle conditions. EMG activity did not increase markedly over time in any condition. Neither objective nor subjective indicators suggested that stress increased over time, regardless of the temporal pattern. Pipetting performance remained stable in all conditions. Cognitive performance, measured by the proportions of correct positive and false positive answers, differed between CTdiff levels but remained stable over time, with no significant difference between temporal patterns. In summary, temporal patterns of alternating tasks influenced fatigue to some extent but had no obvious influence on stress indicators or performance. Thus, designing job rotation with alternating physical and cognitive work should consider the temporal patterns of alternations to minimize fatigue.
Exogenous melatonin induces drought stress tolerance by promoting plant growth and antioxidant defence system of soybean plants
Authors: Imran Muhammad , Latif Khan Abdul , Shahzad Raheem , Aaqil Khan Muhammad , Bilal Saqib , Khan Adil , Kang Sang-Mo , Lee In-Jung 
Published: June 2021

Abstract
Melatonin is an indolamine bioactive molecule that regulates a wide range of physiological processes during plant growth and enhances abiotic stress tolerance. Here we examined the putative role of exogenous melatonin application (foliar or root zone) in improving drought stress tolerance in soybean seedlings. Pre-treatment of soybean seedlings with melatonin (50 and 100 µM) was found to significantly mitigate the negative effects of drought stress on plant growth-related parameters and chlorophyll content. The beneficial impacts against drought were more pronounced by melatonin application in the rhizosphere than in foliar treatments. The melatonin-induced enhanced tolerance could be attributed to improved photosynthetic activity, reduction of abscisic acid and drought-induced oxidative damage by lowering the accumulation of reactive oxygen species and malondialdehyde. Interestingly, the contents of jasmonic acid and salicylic acid were significantly higher following melatonin treatment in the root zone than in foliar treatment compared with the control. The activity of major antioxidant enzymes such as superoxide dismutase, catalase, polyphenol oxidase, peroxidase and ascorbate peroxidase was stimulated by melatonin application. In addition, melatonin counteracted the drought-induced increase in proline and sugar content. These findings revealed that modifying the endogenous plant hormone content and antioxidant enzymes by melatonin application improved drought tolerance in soybean seedlings. Our findings provide evidence for the stronger physiological role of melatonin in the root zone than in leaves, which may be useful in the large-scale field level application during drought.
Male reproductive adjustments to an introduced nest predator
Authors: Gravolin Isaac , Lehtonen Topi K , Deal Nicholas D S , Candolin Ulrika , Wong Bob B M 
Published: June 2021

AbstractNest predation has a large impact on reproductive success in many taxa. Defending offspring from would-be predators can also be energetically and physiologically costly for parents. Thus, to maximize their reproductive payoffs, individuals should adjust their reproductive behaviors in relation to the presence of nest predators. However, effects of nest predator presence on parental behaviors across multiple reproductive contexts remain poorly understood, particularly in non-avian taxa. We ran a series of experiments to test how the presence of an egg predator, the invasive rockpool shrimp, Palaemon elegans, influences male reproductive decisions and egg survival in a species of fish with exclusive paternal care, the three-spined stickleback, Gasterosteus aculeatus. We found that, in the presence of shrimp, male sticklebacks were less likely to build a nest, invested less in territory defense against an intruder, and tended to fan eggs in their nest less and in shorter bouts, but did not alter their investment in courtship behavior. The predator’s presence also did not affect egg survival rates, suggesting that males effectively defended their brood from the shrimp. These results show that reproducing individuals can be highly responsive to the presence of nest predators and adjust their behavioral decisions accordingly across a suite of reproductive contexts.
Significant variation in histopathological assessment of endoscopic resections for Barrett's neoplasia suggests need for consensus reporting: propositions for improvement
Authors: van der Wel M J , Klaver E , Pouw R E , Brosens L A A , Biermann K , Doukas M , Huysentruyt C , Karrenbeld A , ten Kate F J W , Kats-Ugurlu G , van der Laan J , van Lijnschoten I , Moll F C P , Offerhaus G J A , Ooms A H A G , Seldenrijk C A , Visser M , Tijssen J G , Meijer S L , Bergman J J G H M 
Published: June 2021

Abstract
Endoscopic resection (ER) is an important diagnostic step in management of patients with early Barrett’s esophagus (BE) neoplasia. Based on ER specimens, an accurate histological diagnosis can be made, which guides further treatment. Based on depth of tumor invasion, differentiation grade, lymphovascular invasion, and margin status, the risk of lymph node metastases and local recurrence is judged to be low enough to justify endoscopic management, or high enough to warrant invasive surgical esophagectomy. Adequate assessment of these histological risk factors is therefore of the utmost importance. Aim of this study was to assess pathologist concordance on these histological features on ER specimens and evaluate causes of discrepancy. Of 62 challenging ER cases, one representative H&E slide and matching desmin and endothelial marker were digitalized and independently assessed by 13 dedicated GI pathologists from 8 Dutch BE expert centers, using an online assessment module. For each histological feature, concordance and discordance were calculated. Clinically relevant discordances were observed for all criteria. Grouping depth of invasion categories according to expanded endoscopic treatment criteria (T1a and T1sm1 vs. T1sm2/3), ≥1 pathologist was discrepant in 21% of cases, increasing to 45% when grouping diagnoses according to the traditional T1a versus T1b classification. For differentiation grade, lymphovascular invasion, and margin status, discordances were substantial with 27%, 42%, and 32% of cases having ≥1 discrepant pathologist, respectively. In conclusion, histological assessment of ER specimens of early BE cancer by dedicated GI pathologists shows significant discordances for all relevant histological features. We present propositions to improve definitions of diagnostic criteria.
Functional analysis of cysteine residues of the Hok/Gef type I toxins in Escherichia coli
Authors: Wilmaerts Dorien , De Loose Pieter-Jan , Vercauteren Silke , De Smedt Sandrien , Verstraeten Natalie , Michiels Jan 
Published: June 2021

ABSTRACT
The Hok/Gef family consists of structurally similar, single-span membrane peptides that all contain a positively charged N-terminal domain, an α-helix and a periplasmic C-terminal domain. Hok/Gef peptides have previously been described to play distinct physiological roles. Indeed, while HokB has been implicated in bacterial persistence, other members of the Hok/Gef family are known to induce cell lysis. However, the generalizability of previously published studies is problematic, as they have all used different expression systems. Therefore, we conducted a systematic study of the nine Hok/Gef peptides of Escherichia coli. We observed rapid cell death following expression of hokA, hokC, hokD, hokE, pndA1, hok or srnB, while expression of hokB or pndA2 does not result in cell lysis. A remarkable feature of Hok/Gef peptides is the presence of conserved periplasmic tyrosine and/or cysteine residues. For the HokB peptide, one of these residues has previously been implicated in intermolecular dimerization, which is essential for HokB to exert its role in persistence. To assess the role of the periplasmic cysteine and tyrosine residues in other Hok/Gef peptides and to decipher whether these residues determine peptide toxicity, an array of substitution mutants were constructed. We found that these residues are important activators of toxicity for Hok, HokA and HokE peptides. Despite the loss of the cell killing phenotype in HokS31_Y48, HokAS29_S46 and HokES29_Y46, these peptides do not exert a persister phenotype. More research is needed to fully comprehend why HokB is the sole peptide of the Hok/Gef family that mediates persistence.