bluuebunny/crossref_metadata_2025_split huggingface dataset:
PollMap: a software for crop pollination mapping in agricultural landscapes
Authors: Rahimi Ehsan , Barghjelveh Shahindokht , Dong Pinliang , Pirlar Maghsoud Arshadi , Jahanbakhshian Mohammad Mehdi 
Published: November 2021

Abstract
Background
Ecosystem service mapping is an important tool for decision-making in landscape planning and natural resource management. Today, pollination service mapping is based on the Lonsdorf model (InVEST software) that determines the availability of nesting and floral resources for each land cover and estimates pollination according to the foraging range of the desired species. However, it is argued that the Lonsdorf model has significant limitations in estimating pollination in a landscape that can affect the results of this model.

Results
This paper presents a free software, named PollMap, that does not have the limitations of the Lonsdorf model. PollMap estimates the pollination service according to a modified version of the Lonsdorf model and assumes that only cells within the flight range of bees are important in the pollination mapping. This software is produced for estimating and mapping crop pollination in agricultural landscapes. The main assumption of this software is that in the agricultural landscapes, which are dominated by forest and agriculture ecosystems, forest patches serve only as a nesting habitat for wild bees and the surrounding fields provide floral resources.

Conclusion
The present study provided new software for mapping crop pollination in agricultural landscapes that does not have the limitations of the Lonsdorf model. We showed that the use of the Lonsdorf model for pollination mapping requires attention to the limitations of this model, and by removing these limitations, we will need new software to obtain a reliable mapping of pollination in agricultural landscapes.
A unique case of a double intra-conal cavernous hemangioma
Authors: Ulivieri Simone , Luglietto Davide , Ulivieri Matteo , Giorgio Antonio 
Published: November 2021

Abstract
Background
Cavernous hemangiomas are benign vascular malformations, probably representing the most common intraorbital and intraconal tumors in the adult population.

Case presentation
We report the case of a 49-year-old female with two intra-conal lesions. We performed a total resection using Ulivieri's extended lateral approach. The postoperative course was uneventful and the patient was discharged three days after surgery.

Conclusions
To the best of our knowledge, we report here the first case in the literature of a double intra-conal lesion.
Romidepsin Plus CHOP Versus CHOP in Patients With Previously Untreated Peripheral T-Cell Lymphoma: Results of the Ro-CHOP Phase III Study (Conducted by LYSA)
Authors: Bachy Emmanuel , Camus Vincent , Thieblemont Catherine , Sibon David , Casasnovas René-Olivier , Ysebaert Loïc , Damaj Gandhi , Guidez Stéphanie , Pica Gian Matteo , Kim Won Seog , Lim Soon Thye , André Marc , García-Sancho Alejandro Martín , Penarrubia Maria Jesus , Staber Philipp B. , Trotman Judith , Hüttmann Andreas , Stefoni Vittorio , Re Alessandro , Gaulard Philippe , Delfau-Larue Marie-Helene , de Leval Laurence , Meignan Michel , Li Ju , Morschhauser Franck , Delarue Richard 
Published: November 2021

PURPOSE Romidepsin, a histone deacetylase inhibitor, has demonstrated activity in relapsed or refractory peripheral T-cell lymphoma (PTCL) as a single agent. Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) therapy is widely used as first-line treatment of PTCL; however, it has limited efficacy. Results from a phase Ib and II study showed the feasibility of combining romidepsin with CHOP (Ro-CHOP). METHODS This study is a randomized phase III study of Ro-CHOP versus CHOP in adult patients with previously untreated PTCL. All patients received CHOP in 3-week cycles for six cycles. Romidepsin, 12 mg/m2, was administered intravenously over a 4-hour period on days 1 and 8 of each 3-week cycle for six cycles. The primary end point was progression-free survival (PFS) according to International Working Group 1999 criteria. RESULTS Between January 2013 and December 2017, 421 patients were enrolled (Ro-CHOP, n = 211; CHOP, n = 210). The median PFS for Ro-CHOP versus CHOP was 12.0 months (95% CI, 9.0 to 25.8) versus 10.2 months (95% CI, 7.4 to 13.2) with a hazard ratio of 0.81 ( P = .096). In the Ro-CHOP versus CHOP arms, the median overall survival was 51.8 versus 42.9 months and the objective response rate was 63% versus 60% with complete response plus unconfirmed complete response rates of 41% versus 37% ( P > .1 in all comparisons), respectively. Grade 3 or 4 treatment-emergent adverse events occurring in ≥ 30% of patients in the Ro-CHOP arm included thrombocytopenia (50% v 10% in the Ro-CHOP v CHOP arms, respectively), neutropenia (49% v 33%), anemia (47% v 17%), and leukopenia (32% v 20%). CONCLUSION The addition of romidepsin to CHOP did not improve PFS, response rates, nor overall survival and increased the frequency for grade ≥ 3 treatment-emergent adverse events. Ro-CHOP does not represent a significant advance in the standard of care for patients with previously untreated PTCL.
Poiesis as Decision Making: Shklovsky, Tynianov, Bakhtin
Authors: Steiner Peter 
Published: November 2021

Abstract
This article deals with the theories of Viktor Shklovsky and Iurii Tynianov from the perspective of decision science. It outlines how these two members of the Petersburg Society for the Study of Poetic Language (OPOIAZ) conceived of the writer as a rational agent pursuing a specific goal, and of the means at his or her disposal to attain it. Their approaches, the article illustrates, correspond closely with two specific types of rationality: “instrumental” and “bounded.” To conclude, the essay juxtaposes the formalists’ conceptualization of poetic creativity with Mikhail Bakhtin's view on the subject, arguing that the way he conceives of the strategies available to the literary author fits the label of “interactive rationality.”
Sinophonic Detours in Colonial Burma
Authors: Bernards Brian 
Published: November 2021

Abstract
Following his 1925–1931 overland trek across southwestern China to colonial Burma, Ai Wu's 1935 Travels in the South (the author's canonical collection of autobiographical travelogue fiction) represents a Sinophonic detouring of the key literary impulses of the author's May Fourth forebears and his left-wing literary contemporaries, especially with its social realist expressions of gendered frontier primitivism, interethnic romantic desire, and international leftist solidarity. Ai Wu's southbound transborder itinerary and “street education”—marked by a repetition of trespasses and evictions—develop a “counterpoetics of trespass” blurring boundaries between social realist fiction and autobiographical travelogue while intertextually rerouting romantic primitivism in depictions of indigenous women through counterpoetically anemic prose. Initially taking his cue from Lu Xun, Ai Wu similarly inscribes his literary mission as one of national redemption but in a way that conforms to the leftist internationalist ideals of the League of Left-Wing Writers, which Ai Wu joined after he was forcibly repatriated to China by British colonial authorities in 1931. Ai Wu's Sinophone transborder counterpoetics activate latent self-reflections on the narrator's own male Han-centric exoticism toward indigenous Shan and Burman women and on his unfulfilled desire to forge meaningful relationships with them. Rather than assimilating or subordinating his depictions of these women into a projection of a Chinese leftist national cause, Ai Wu ultimately sublimates his romantic desires into an allegory for Burma's anticolonial resistance movement.
Vitamin A cycle byproducts explain retinal damage and molecular changes thought to initiate retinal degeneration
Authors: Zhang Dan , Mihai Doina M. , Washington Ilyas 
Published: November 2021

ABSTRACT
In the most prevalent retinal diseases, including Stargardt disease and age-related macular degeneration (AMD), byproducts of vitamin A form in the retina abnormally during the vitamin A cycle. Despite evidence of their toxicity, whether these vitamin A cycle byproducts contribute to retinal disease, are symptoms, beneficial, or benign has been debated. We delivered a representative vitamin A byproduct, A2E, to the rat's retina and monitored electrophysiological, histological, proteomic, and transcriptomic changes. We show that the vitamin A cycle byproduct is sufficient alone to damage the RPE, photoreceptor inner and outer segments, and the outer plexiform layer, cause the formation of sub-retinal debris, alter transcription and protein synthesis, and diminish retinal function. The presented data are consistent with the theory that the formation of vitamin A byproducts during the vitamin A cycle is neither benign nor beneficial but may be sufficient alone to cause the most prevalent forms of retinal disease. Retarding the formation of vitamin A byproducts could potentially address the root cause of several retinal diseases to eliminate the threat of irreversible blindness for millions of people.
Brain transcriptomes of zebrafish and mouse Alzheimer's disease knock-in models imply early disrupted energy metabolism
Authors: Barthelson Karissa , Newman Morgan , Lardelli Michael 
Published: November 2021

ABSTRACTEnergy production is the most fundamentally important cellular activity supporting all other functions, particularly in highly active organs, such as brains. Here, we summarise transcriptome analyses of young adult (pre-disease) brains from a collection of 11 early-onset familial Alzheimer's disease (EOFAD)-like and non-EOFAD-like mutations in three zebrafish genes. The one cellular activity consistently predicted as affected by only the EOFAD-like mutations is oxidative phosphorylation, which produces most of the energy of the brain. All the mutations were predicted to affect protein synthesis. We extended our analysis to knock-in mouse models of APOE alleles and found the same effect for the late onset Alzheimer's disease risk allele ε4. Our results support a common molecular basis for the initiation of the pathological processes leading to both early and late onset forms of Alzheimer's disease, and illustrate the utility of zebrafish and knock-in single EOFAD mutation models for understanding the causes of this disease.
Vangl2–environment interaction causes severe neural tube defects, without abnormal neuroepithelial convergent extension
Authors: Nychyk Oleksandr , Galea Gabriel L. , Molè Matteo , Savery Dawn , Greene Nicholas D. E. , Stanier Philip , Copp Andrew J. 
Published: November 2021

ABSTRACT
Planar cell polarity (PCP) signalling is vital for initiation of mouse neurulation, with diminished convergent extension (CE) cell movements leading to craniorachischisis, a severe neural tube defect (NTD). Some humans with NTDs also have PCP gene mutations but these are heterozygous, not homozygous as in mice. Other genetic or environmental factors may interact with partial loss of PCP function in human NTDs. We found that reduced sulfation of glycosaminoglycans interacts with heterozygosity for the Lp allele of Vangl2 (a core PCP gene), to cause craniorachischisis in cultured mouse embryos, with rescue by exogenous sulphate. We hypothesized that this glycosaminoglycan–PCP interaction may regulate CE, but, surprisingly, DiO labelling of the embryonic node demonstrates no abnormality of midline axial extension in sulfation-depleted Lp/+ embryos. Positive-control Lp/Lp embryos show severe CE defects. Abnormalities were detected in the size and shape of somites that flank the closing neural tube in sulfation-depleted Lp/+ embryos. We conclude that failure of closure initiation can arise by a mechanism other than faulty neuroepithelial CE, with possible involvement of matrix-mediated somite expansion, adjacent to the closing neural tube.
Cofilin regulates actin network homeostasis and microvilli length in mouse oocytes
Authors: Bourdais Anne , Dehapiot Benoit , Halet Guillaume 
Published: November 2021

ABSTRACT
How multiple actin networks coexist in a common cytoplasm while competing for a shared pool of monomers is still an ongoing question. This is exemplified by meiotic maturation in the mouse oocyte, which relies on the dynamic remodeling of distinct cortical and cytoplasmic F-actin networks. Here, we show that the conserved actin-depolymerizing factor cofilin is activated in a switch-like manner upon meiosis resumption from prophase arrest. Interfering with cofilin activation during maturation resulted in widespread elongation of microvilli, while cytoplasmic F-actin was depleted, leading to defects in spindle migration and polar body extrusion. In contrast, cofilin inactivation in metaphase II-arrested oocytes resulted in a shutdown of F-actin dynamics, along with a dramatic overgrowth of the polarized actin cap. However, inhibition of the Arp2/3 complex to promote actin cap disassembly elicited ectopic microvilli outgrowth in the polarized cortex. These data establish cofilin as a key player in actin network homeostasis in oocytes and reveal that microvilli can act as a sink for monomers upon disassembly of a competing network.
Muonium Addition to the Radicalic Carbon in 1,3-Diphosphacyclobutane-2,4-diyl
Authors: Ito Shigekazu , Akama Hikaru , Ueta Yasuhiro , McKenzie Iain , Kojima Kenji M 
Published: November 2021

Abstract
When a crystalline 1,3-diphosphacyclobutane-2,4-diyl bearing a 3,5-dichloro-2,4,6-triazine substituent was irradiated with muon beam, two paramagnetic species showing muon hyperfine coupling constants (hfcs) of 4.5 MHz and 6.5 MHz were produced via addition of muonium. These observed paramagnetic species are consistent with the cis and trans isomers of the C-muoniated 1,3-diphosphacyclobutane-2,4-diyl.
Reductive Coupling of Isatins with α,β-Unsaturated Carbonyl Compounds by Low-Valent Titanium
Authors: Kise Naoki , Mitsui Yuki , Sakurai Toshihiko 
Published: November 2021

Abstract
The reductive coupling of isatins with α,β-unsaturated carbonyl compounds by Zn-TiCl4 in THF at 0 °C gave one-to-one coupled products, 3-hydoxy-3-alkyloxindoles. The coupled products obtained from α,β-unsaturated esters were transformed to the corresponding spiro-γ-lactones by refluxing in cat. PPTS/benzene. The two-to-one coupled products, 3,3-bis(2-carbomethoxyethyl)oxindoles, were formed by the reduction of isatins with methyl acrylate by Zn-TiCl4 in THF at 30 °C. The one-to-one coupled products obtained from the reductive coupling of isatins with methyl acrylate were reduced to 3-(2-carbomethoxyethyl)oxindoles by Zn-TiCl4 in THF at 30 °C. The 3-(2-carbomethoxyethyl)oxindoles added to acrylonitrile to give 3-(2-carbomethoxyethyl)-3-(2-cyanoethyl)oxindoles.
The Origins of Formation of Descriptive Geometry
Authors: Sal'kov N. 
Published: November 2021

The translation "Descriptive geometry" is not entirely accurate. In fact, the phrase should be translated as "Narrative geometry". Based on this translation, it can be confidently stated that the science under consideration serves not only as a theoretical basis for orthogonal projections, a special case of which are ordinary drawings, but also for any images – in this the author of the article fully agrees with such authorities as N.A. Rynin, N.F. Chetverukhin, V.O. Gordon, S.A. Frolov, N.A. Sobolev and many others.
The paper considers the origins of one of the directions of geometry – descriptive geometry. The hypothesis is put forward that in reality descriptive geometry, or rather, its elements, was originally involved in ancient times, during the primitive communal system when making drawings on the walls of caves and rocks. Orthogonal projections were used in the ancient world and in the Middle Ages, and Gaspard Monge at the end of the XVIII century systematized all the existing disconnected developments on descriptive geometry, adding his own research.
Most likely, geometry in general was the very first science that originated when our ancestors who lived in caves faced the problem of increasing the living area due to population growth. And descriptive geometry began to develop from the moment when the first artist depicted scenes from life on the cave wall: hunting, fishing, tribal wars, events that shocked people, etc. Ancient artists existed on all continents of the globe, except perhaps Antarctica, since rock carvings were found on all other continents. And the earliest was performed somewhere 25-30 thousand years ago. Thus, the hypothesis that the elements of descriptive geometry originated in the primitive communal system can be considered proven.
Black and White: Access to Capital Among Minority-Owned Start-ups
Authors: Fairlie Robert , Robb Alicia , Robinson David T. 
Published: November 2021

We used confidential and restricted-access data from the Kauffman Firm Survey and matched administrative data on credit scores to explore racial disparities in access to capital for new business ventures. The novel results on racial inequality in start-up financing indicate that Black-owned start-ups start smaller and stay smaller over the entire first eight years of their existence. Black start-ups face more difficulty in raising external capital, especially external debt. We find that disparities in creditworthiness constrain Black entrepreneurs, but perceptions of treatment by banks also hold them back. Black entrepreneurs apply for loans less often than White entrepreneurs largely because they expect to be denied credit, even when they have a good credit history and in settings where strong local banks favor new business development. This paper was accepted by David Simchi-Levi, finance.
Time-Varying Skew in VIX Derivatives Pricing
Authors: Yuan Peixuan 
Published: November 2021

This paper proposes a new reduced-form model for the pricing of VIX derivatives that includes an independent stochastic jump intensity factor and cojumps in the level and variance of VIX, while allowing the mean of VIX variance to be time varying. I fit the model to daily prices of futures and European options from April 2007 through December 2017. The empirical results indicate that the model significantly outperforms all other nested models and improves on benchmark by 21.6% in sample and 31.2% out of sample. The model more accurately portrays the tail behavior of VIX risk-neutral distribution for both short and long maturities, as it better captures the time-varying skew found to be largely independent of the level of the VIX smile. This paper was accepted by Kay Giesecke, finance.
Molecular epidemiology of Paracoccidiodes spp. recovered from patients with paracoccidioidomycosis in a teaching hospital from Minas Gerais State of Brazil
Authors: Andrade-Silva Juliana , Andrade-Silva Leonardo Euripedes , Paes Hugo Costa , Alves Lucas , Rosa Adair , Tenório Bernardo Guerra , Ferreira Marcelo Simão , Felipe Maria Sueli Soares , Teixeira Marcus de Melo , Silva-Vergara Mario León 
Published: November 2021

Introduction
Paracoccidioidomycosis (PCM) is caused by several species of the Paracoccidioides genus which can be differentiated by interspecific genetic variations, morphology and geographic distribution. Intraspecific variability correlation with clinical and epidemiological aspects of these species still remains unclear. This study aimed to sequence the loci GP43, exon 2 and ARF of 23 clinical isolates of Paracoccidioides spp. from patients in the Southeast Region of Brazil.

Methodology and main findings
GenBank was used to compare the present (23) with previous described sequences (151) that included ARF and GP43. It was identified a high polymorphism rate among the 23 isolates in comparison to the other 151. Among the isolates, 22 (95.66%) were S1/P. brasiliensis and 1 (4.34%) was identified as PS2/P. americana. A total of 45 haplotypes were found as follows: 19 from S1/P. brasiliensis (13 from the present study), 15 from P. lutzii, 6 from PS2/P. americana (1 from the present study), 3 from PS3/P. restrepiensis and 2 from PS4/P. venezuelensis. Moreover, exclusive haplotypes according to clinical origin and geographical area were found. S1/P. brasiliensis (HD = 0.655 and K = 4.613) and P. lutzii (HD = 0.649 and K = 2.906) presented the highest rate of polymorphism among all species, from which 12 isolates of the present study were clustered within S1b/P. brasiliensis. The GP43 locus showed a higher variability and was found to be the main reason for the species differentiation.

Conclusions
The results herein decribed show a high intraspecific genetic variability among S1/P. brasiliensis isolates and confirm the predominance of this species in the Southeast region of Brazil. The finding of exclusive haplotypes according to clinical origin and geographical area would suggest correlation between the molecular profile with the clinical form and geographic origin of patients with PCM.
Factors influencing recurrence after complete remission in children with hepatoblastoma: A 14-year retrospective study in China
Authors: Li Fan , Zhang Weiling , Hu Huimin , Zhu Xia , Zhang Yi , Huang Dongsheng 
Published: November 2021

Objective
After a complete remission to treatment for hepatoblastoma, some children still have recurrence. We identified and explored the factors that influence recurrence after complete remission in a retrospective study.

Methods
Of 197 children with hepatoblastoma, 140 (71.1%) achieved initial complete remission and were enrolled in factor analysis. Variables consisted of age, sex, PRE-Treatment EXTent of tumor (PRETEXT) stage, pathologic type, metastatic disease, serum alpha-fetoprotein level, vascular involvement, and surgical margin status. We employed univariate and multivariate analyses to assess the relationship between each factor and tumor recurrence.

Results
Of 140 children who achieved initial complete remission, 42 (30%) had recurrent hepatoblastoma. The 5-year overall survival rates for the non-recurrence and recurrence group were 99.0% and 78.6%, respectively. The overall 1-year, 3-year, and 5-year recurrence-free survival (RFS) rates were 77.8%, 69.8%, and 69.8%, respectively. All recurrences occurred within 2 years from complete remission. The RFS rate was significantly higher in children younger than 3 years and in those with mixed pathological type, PRETEXT II and III, without metastatic disease, without vascular involvement, and microscopic negative margin than in that of children older than 3 years, with epithelial pathological type, PRETEXT IV, metastatic disease, vascular involvement, and macroscopic positive margin (P < 0.001, = 0.020, < 0.001, = 0.004, = 0.002, and < 0.001, respectively). The independent risk factors for recurrence after complete remission were age ≥3 years, PRETEXT IV, and metastatic disease (P < 0.05).

Conclusion
Age, PRETEXT stage, metastatic disease, vascular involvement, pathologic type, and surgical margin status might be associated with recurrent hepatoblastoma after complete remission; meanwhile, age ≥3 years, PRETEXT IV, and metastatic disease are independent risk factors of recurrence. Further research is needed on the causes of tumor recurrence, which may improve the long-term outcomes of children with hepatoblastoma.