bluuebunny/crossref_metadata_2025_split huggingface dataset:
Menelaah Rencana Kenaikan Tarif PPN Berdasarkan Bukti Empiris Serta Dampaknya Secara Makro Ekonomi
Authors: Liyana Nur Farida 
Published: December 2021

Rencana kenaikan tarif PPN menjadi 11 persen pada tahun 2022 telah menimbulkan kegelisahan di masyarakat. Ditengah pandemic covid-19 dan ekonomi yang belum pulih, bayangan perihal harga komoditas naik yang kemudian diiringi dengan inflasi tentunya meresahkan tidak hanya bagi pengusaha namun juga masyarakat biasa. Untuk itu di dalam tulisan ini dilakukan pembuktian empiris dengan menggunakan regresi OLS untuk menguji hubungan antara PPN dengan pertumbuhan ekonomi serta tingkat tabungan nasional di Indonesia. Kemudian akan dianalisis dampak rencana kenaikan tarif PPN tersebut secara makro ekonomi dengan melakukan perbandingan pengalaman Jepang yang pernah menaikkan tarif PPN nya sebanyak 3 (tiga) kali selama 15 tahun terakhir. Diperoleh kesimpulan bahwa apa yang dilakukan pemerintah sudah pada jalur yang benar karena bukti empiris menyatakan hubungan positif signifikan antara PPN dan PDB serta tabungan nasional. Sehingga dengan menaikkan tarif PPN diharapkan akan mendorong pertumbuhan ekonomi dan menarik pembiayan luar negeri ke Indonesia. Namun demikian, perlu dianalisis terlebih dahulu dampak kenaikan tarif PPN terhadap ekonomi makro. Berdasarkan pembelajaran dari Jepang, ternyata kenaikan tarif PPN tidak mampu menaikkan konsumsi dan pertumbuhan ekonomi namun justru menaikkan inflasi. Hal ini perlu menjadi perhatian khusus bagi Pemerintah Indinesia sehingga perlu usaha untuk memitigasi hal-hal tersebut.
“O MUNDÃO SEM PORTEIRA”
Authors: Chaveiro Eguimar Felício , Soares Fernando Uhlmann , Oliveira Adão Francisco de 
Published: December 2021

A narrativa de Bernardo Élis é uma das maiores fontes de leitura de Goiás. Originária de uma tradição regionalista, mas com timbre próprio, a sua obra, em forma de contos, poesias e romances, situada histórico e espacialmente, enreda os problemas dramáticos do sertanejo goiano. Com o objetivo de interpretar pontos da representação de Goiás detidamente no modo como a obra narra os Ermos goianos, ou o “mundão sem porteira”, este trabalho decorre de um arco de diálogos constituídos no ativismo dinâmico promovido pelo Instituto Cultural e Educacional Bernardo Élis para os Povos do Cerrado (ICEBE). Uma problemática mobiliza a reflexão: como a ficção bernardiana contribui para ler Goiás?
Palavras-chaves. Ermos, mundo sertanejo, narrativa, regionalista, representação de Goiás.
BERNARDO ÉLIS
Authors: Catelan Álvaro 
Published: December 2021

No conto A virgem santíssima do quarto de Joana, de Bernardo Élis, a violência é narrada pelo fio da perda da sanidade da personagem principal. Ao tempo em que se desenrola a sua história, ela se esvai diante de nossos olhos. Além da violência que é o fio condutor da obra, nela, é possível entrever todas as principais características da produção de Élis: a religiosidade e a pobreza do sertão, a “república do coronelismo”. Mas a forma como Joana vive e morre leva à reflexão da naturalidade com a qual esses atos violentos fazem parte do dia a dia daquele grupo, na esteira da discussão de Homens livres na ordem escravocrata, de Maria Sylvia de Carvalho Franco.
Palavras-chave. Bernardo Élis, violência, estudos de gênero.
Blood Glucose Levels in Trimester I And II Trimester PROLANIS Patients
Authors: Dewi Mahardika Putri Sintya 
Published: December 2021

Blood glucose level checks are generally carried out for people with Diabetes Mellitus (DM) to establish the diagnosis and monitor therapy and the emergence of complications, thus the progress of the disease can be monitored. Examination of blood glucose levels during or ad random can measure blood glucose levels without measuring the time of the last meal. The puskesmas has a Chronic Disease Control Program (PROLANIS) which aims to encourage participants with chronic illness to achieve optimal quality of life. PROLANIS is held every month by giving drugs and blood glucose checks when, in trimester I prolanis patients high sugar levels should be decreased in trimester II. Objective to find out the description of blood glucose levels when in trimester I and trimester prolanis patients in Banyumas Wangon II Health Center in 2019. Research Methods this study was an observational study with descriptive research criteria with a sample of all PROLANIS patients who examined blood glucose levels. Results the study subjects were 45 PROLANIS patients who were examined for blood glucose levels at the time. The results showed that 6 patients were male (41.31%) and 39 patients were female (58.69%) Conclusion this study shows the results of glucose levels in PROLANIS patients the highest male sex in trimester I was 901 and trimester II was 657, the highest blood glucose level in I trimester I was 1372 and trimester II 841. Compliance with this treatment remained a decline main measure in the process of changing blood glucose levels.
A extensão universitária como agente transformadora da sociedade: estudo de caso da Biblioteca Comunitária do bairro Saramenha de Cima - Ouro Preto/MG
Authors: Figueiredo Thiago Duarte , Alves Caio Cesar Gonzaga , Souza Crislaine , Rodrigues Guilherme Henrique Gualandi , Pereira Carlos Alberto 
Published: December 2021

As bibliotecas comunitárias são ambientes sociais criados pela própria comunidade para promover acesso à informação e lazer à população local. Esses ambientes se tornam importantes pontos de apoio, reduzindo desigualdades sociais e garantindo o desenvolvimento pedagógico e cultural. Nesse contexto, no ano de 2005, foi criada a Biblioteca Comunitária de Saramenha de Cima, no bairro de mesmo nome na cidade de Ouro Preto-MG, numa parceria entre grupos locais e Universidade Federal de Ouro Preto (UFOP). A biblioteca promove atividades de estímulo à leitura, oficinas, reforço escolar e empréstimos de livros, com participação de alunos de extensão universitária dos cursos de graduação da UFOP nas atividades do projeto. Esse artigo avalia o impacto da Biblioteca Comunitária de Saramenha de Cima na melhoria da educação e qualidade de vida da população local, por meio de levantamento de dados de desempenho escolar das crianças participantes, análises dos principais pontos de transformação do projeto na comunidade e no desenvolvimento pessoal e acadêmico dos extensionistas. O estudo destacou como o projeto trouxe o sentimento de orgulho e pertencimento à população local, se tornando ponto de lazer, cultura e, principalmente, desenvolvimento educacional, com a escola do bairro obtendo crescente rendimento acadêmico com apoio da biblioteca, obtendo resultados superiores as médias municipal, estadual e nacional. Além disso, o projeto promove a aproximação entre a comunidade e a universidade, garantindo também um amadurecimento pessoal importantíssimo aos extensionistas participantes, preparando os no âmbito acadêmico, com apresentação de trabalhos relacionados e tornando-os mais humanos e melhor preparados para o futuro.
Klasifikasi Penyakit Pada Citra Daun Jeruk Menggunakan Arsitektur MobileNet berbasis Mobile Platform
Authors: Riswandi Riswandi , Jamiah Rosmiati , Mardhatillah Nisa , Hamid Hady Prasetya 
Published: December 2021

Proses diagnosa penyakit pada tanaman daun jeruk umunya dilakukan melalui pemeriksaan laboratorium oleh seorang ahli patologi tumbuhan dengan melihat gejala visual yang timbul pada tanaman untuk membantu petani daun jeruk dalam memberikan pola penanganan yang tepat berdasarkan gejala yang nampak pada kondisi daun jeruk. Klasifikasi penyakit daun jeruk menggunakan metode pengolahan citra mampu memberikan referensi diagnosis yang cepat dan akurat. Penelitian ini mengusulkan pendekatan deep learning menggunakan arsitektur MobineNet CNN untuk melakukan klasifikasi. Metode pada penelitian ini dievaluasi pada citra penyakit daun jeruk dalam tiga kategori yaitu normal, HLB dan CTV dengan ukuran citra 150x150. Pengujian dilakukan dengan menggunakan algortima RMSprof optimize dengan learning rate 0.001. Proses pelatihan menggunakan arsitektur Binary Cross Entropy fungsi aktivasi sigmoid. Hasi klasifikasi penyakit pada citra daun jeruk pada proses training mencapai tingkat akurasi 98% pada epoch 15.
Mass Transfer in Hierarchical Silica Monoliths Loaded With Pt in the Continuous-Flow Liquid-Phase Hydrogenation of p-Nitrophenol
Authors: Jatoi Haseeb Ullah Khan , Goepel Michael , Poppitz David , Kohns Richard , Enke Dirk , Hartmann Martin , Gläser Roger 
Published: December 2021

Sol-gel-based silica monoliths with hierarchical mesopores/macropores are promising catalyst support and flow reactors. Here, we report the successful preparation of cylindrically shaped Pt-loaded silica monoliths (length: 2 cm, diameter: 0.5 cm) with a variable mean macropore width of 1, 6, 10, or 27 μm at a fixed mean mesopore width of 17 nm. The Pt-loaded monolithic catalysts were housed in a robust cladding made of borosilicate glass for use as a flow reactor. The monolithic reactors exhibit a permeability as high as 2 μm2 with a pressure drop below 9 bars over a flow rate range of 2–20 cm3 min−1 (solvent: water). The aqueous-phase hydrogenation of p-nitrophenol to p-aminophenol with NaBH4 as a reducing agent was used as a test reaction to study the influence of mass transfer on catalytic activity in continuous flow. No influence of flow rate on conversion at a fixed contact time of 2.6 s was observed for monolithic catalysts with mean macropore widths of 1, 10, or 27 µm. As opposed to earlier studies conducted at much lower flow velocities, this strongly indicates the absence of external mass-transfer limitations or stagnant layer formation in the macropores of the monolithic catalysts.
Vitamin E Acetate Determination in Vaping Liquids and Non-targeted Analysis of Vaping Emissions of Diluents of Concern, Vitamin E Acetate and Medium-Chain Triglycerides Oil
Authors: Kosarac Ivana , Kubwabo Cariton , Katuri Guru Prasad , Petraccone Dora , Mischki Trevor K. 
Published: December 2021

During the summer of 2019, cases of lung injury associated with vaping emerged in North America, including among individuals who reported exclusive use of nicotine vaping liquids. Once vitamin E acetate was identified as a potential causative agent a quantitative method based on a simple sample dilution, separation by gas chromatography and analysis by triple quadrupole mass spectrometry (GC MSMS) was developed. Method detection limit (MDL) and limit of quantification (LOQ) were determined at 0.159 µg/mL and 0.505 µg/mL, respectively. The analysis was performed on a subset of 203 commercially sourced nicotine containing vaping liquids of various flavour profile and nicotine range (nicotine free-59 mg/mL) from an internal inventory. The target analyte, Vitamin E Acetate, was not detected in any samples analyzed, as expected, given the reported detection in literature and high association of the chemical with cannabis and not nicotine containing vaping products.
Construction of UiO-66/Bi4O5Br2 Type-II Heterojunction to Boost Charge Transfer for Promoting Photocatalytic CO2 Reduction Performance
Authors: Li Dongsheng , Zhu Bichen , Sun Zhongti , Liu Qinqin , Wang Lele , Tang Hua 
Published: December 2021

One of the basic challenges of CO2 photoreduction is to develop efficient photocatalysts, and the construction of heterostructure photocatalysts with intimate interfaces is an effective strategy to enhance interfacial charge transfer for realizing high photocatalytic activity. Herein, a novel UiO-66/Bi4O5Br2 heterostructure photocatalyst was constructed by depositing UiO-66 nanoparticles with octahedral morphology over the Bi4O5Br2 nanoflowers assembled from the Bi4O5Br2 nanosheets via an electrostatic self-assembly method. A tight contact interface and a built-in electric field were formed between the UiO-66 and the Bi4O5Br2, which was conducive to the photo-electrons transfer from the Bi4O5Br2 to the UiO-66 and the formation of a type-II heterojunction with highly efficient charge separation. As a result, the UiO-66/Bi4O5Br2 exhibited improved photocatalytic CO2 reduction performance with a CO generation rate of 8.35 μmol h−1 g−1 without using any sacrificial agents or noble co-catalysts. This work illustrates an applicable tactic to develop potent photocatalysts for clean energy conversion.
Phosphoproteomic Analysis Reveals Downstream PKA Effectors of AKAP Cypher/ZASP in the Pathogenesis of Dilated Cardiomyopathy
Authors: Lv Jialan , Pan Zhicheng , Chen Jian , Xu Rui , Wang Dongfei , Huang Jiaqi , Dong Yang , Jiang Jing , Yin Xiang , Cheng Hongqiang , Guo Xiaogang 
Published: December 2021

Background: Dilated cardiomyopathy (DCM) is a major cause of heart failure worldwide. The Z-line protein Cypher/Z-band alternatively spliced PDZ-motif protein (ZASP) is closely associated with DCM, both clinically and in animal models. Our earlier work revealed Cypher/ZASP as a PKA-anchoring protein (AKAP) that tethers PKA to phosphorylate target substrates. However, the downstream PKA effectors regulated by AKAP Cypher/ZASP and their relevance to DCM remain largely unknown.Methods and Results: For the identification of candidate PKA substrates, global quantitative phosphoproteomics was performed on cardiac tissue from wild-type and Cypher-knockout mice with PKA activation. A total of 216 phosphopeptides were differentially expressed in the Cypher-knockout mice; 31 phosphorylation sites were selected as candidates using the PKA consensus motifs. Bioinformatic analysis indicated that differentially expressed proteins were enriched mostly in cell adhesion and mRNA processing. Furthermore, the phosphorylation of β-catenin Ser675 was verified to be facilitated by Cypher. This phosphorylation promoted the transcriptional activity of β-catenin, and also the proliferative capacity of cardiomyocytes. Immunofluorescence staining demonstrated that Cypher colocalised with β-catenin in the intercalated discs (ICD) and altered the cytoplasmic distribution of β-catenin. Moreover, the phosphorylation of two other PKA substrates, vimentin Ser72 and troponin I Ser23/24, was suppressed by Cypher deletion.Conclusions: Cypher/ZASP plays an essential role in β-catenin activation via Ser675 phosphorylation, which modulates cardiomyocyte proliferation. Additionally, Cypher/ZASP regulates other PKA effectors, such as vimentin Ser72 and troponin I Ser23/24. These findings establish the AKAP Cypher/ZASP as a signalling hub in the progression of DCM.
Individual and Combined Associations of Glucose Metabolic Components With Cognitive Function Modified by Obesity
Authors: He Ruixin , Zheng Ruizhi , Li Jie , Cao Qiuyu , Hou Tianzhichao , Zhao Zhiyun , Xu Min , Chen Yuhong , Lu Jieli , Wang Tiange , Xu Yu , Bi Yufang , Wang Weiqing , Li Mian , Liu Yan , Ning Guang 
Published: December 2021

AimWe aimed to detect the individual and combined effect of glucose metabolic components on cognitive function in particular domains among older adults.MethodsData of 2,925 adults aged over 60 years from the 2011 to 2014 National Health and Nutrition Examination Survey were analyzed. Individuals’ cognitive function was evaluated using the Digit Symbol Substitution Test (DSST), the Animal Fluency Test (AF), the Consortium to Establish a Registry for Alzheimer’s Disease Immediate Recall (CERAD-IR), and CERAD Delayed Recall (CERAD-DR). Participants’ glucose metabolic health status was determined based on fasting plasma glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), glycated hemoglobin (HbA1c), and 2-h postload glucose. Linear regression models were used to delineate the associations of cognitive function with individual glucose metabolic component and with metformin use. Logistic regression models were performed to evaluate the associations of cognition with the number of glucose metabolic risk components.ResultsCERAD-IR was significantly associated with HOMA-IR and insulin. HbA1c was related to all the cognitive tests except AF. Among participants without obesity, HOMA-IR and insulin were both negatively associated with CERAD-IR and CERAD-DR. Odds of scoring low in DSST increased with the number of glucose metabolic risk components (odds ratio 1.94, 95% confidence interval [CI] 1.26 to 2.98). Metformin use was associated with better performance in DSST among diabetes patients (β = 4.184, 95% CI 1.655 to 6.713).ConclusionsOur findings support the associations of insulin resistance and glycemic level with cognitive function in key domains, especially among adults without obesity. There is a positive association between metformin use and cognition.
Association of Quantified Costal Cartilage Calcification and Long-Term Cumulative Blood Glucose Exposure: The Multi-Ethnic Study of Atherosclerosis
Authors: Shabani Mahsima , Pishgar Farhad , Akhtarkhavari Sepehr , Quinaglia Thiago , Budoff Matthew J. , Bluemke David A. , Barr Graham R. , Post Wendy S. , Wu Colin O. , Arbab-Zadeh Armin , Sidhaye Aniket , Lima João A. C. , Demehri Shadpour 
Published: December 2021

AimsAnecdotal reports have suggested increased soft tissue calcification in individuals with long-term exposures to high blood glucose. The association of costal cartilage calcification (CCC), a reliably quantifiable marker obtainable from non-contrast cardiac computed tomography (CT) with cumulative fasting blood glucose (FBG) exposure, is unknown. In this study, we aimed to determine the association between quantified CCC and cumulative glucose exposure using non-contrast coronary artery calcium (CAC) scoring computed tomography (CT) images in the Multi-Ethnic Study of Atherosclerosis (MESA).MethodsThe volume of bilateral CCC was quantified in high-density pixels (threshold of Hounsfield Unit&gt;180) using the CAC scoring CT images acquired in the 5th MESA exam. Prior long-term cumulative exposure to FBG was calculated by area under the FBG-time curve over ten years before the time of the CT exam.ResultsA total of 2,305 participants (mean age: 69, female/male: 1.3) were included in this study. The median CCC volume was lower in females than males (1158 mm3 [IQR: 1751] vs. 3054 mm3 [3851], p&lt;0.001). In cross-sectional analysis, quantified CCC was associated with FBG (9% increase per SD) and HbA1c (7% increase per SD) at the CT exam only in female participants after adjustment for age, race, BMI, and glomerular filtration rate. Only in female participants, quantified CCC was also associated with prior cumulative FBG (3% increase per decile change). In the subgroup of females with zero CAC scores, the adjusted CCC was still associated with FBG (13% increase per SD) at the time of CT exam and with prior cumulative FBG exposure (4% increase per decile change) before the CT exam.ConclusionsThe CCC, a reliably quantified marker in non-contrast cardiac CT, is associated with 10-year cumulative FBG exposure only in female participants, even those with zero CAC.
Donor NK and T Cells in the Periphery of Lung Transplant Recipients Contain High Frequencies of Killer Cell Immunoglobulin-Like Receptor-Positive Subsets
Authors: Hitz Anna-Maria , Bläsing Kim-Alina , Wiegmann Bettina , Bellmàs-Sanz Ramon , Chichelnitskiy Evgeny , Wandrer Franziska , Horn Lisa-Marie , Neudörfl Christine , Keil Jana , Beushausen Kerstin , Ius Fabio , Sommer Wiebke , Avsar Murat , Kühn Christian , Tudorache Igor , Salman Jawad , Siemeni Thierry , Haverich Axel , Warnecke Gregor , Falk Christine S. , Kühne Jenny F. 
Published: December 2021

IntroductionFor end-stage lung diseases, double lung transplantation (DLTx) is the ultimate curative treatment option. However, acute and chronic rejection and chronic dysfunction are major limitations in thoracic transplantation medicine. Thus, a better understanding of the contribution of immune responses early after DLTx is urgently needed. Passenger cells, derived from donor lungs and migrating into the recipient periphery, are comprised primarily by NK and T cells. Here, we aimed at characterizing the expression of killer cell immunoglobulin-like receptors (KIR) on donor and recipient NK and T cells in recipient blood after DLTx. Furthermore, we investigated the functional status and capacity of donor vs. recipient NK cells.MethodsPeripheral blood samples of 51 DLTx recipients were analyzed pre Tx and at T0, T24 and 3wk post Tx for the presence of HLA-mismatched donor NK and T cells, their KIR repertoire as well as activation status using flow cytometry.ResultsWithin the first 3 weeks after DLTx, donor NK and T cells were detected in all patients with a peak at T0. An increase of the KIR2DL/S1-positive subset was found within the donor NK cell repertoire. Moreover, donor NK cells showed significantly higher frequencies of KIR2DL/S1-positive cells (p&lt;0.01) 3wk post DLTx compared to recipient NK cells. This effect was also observed in donor KIR+ T cells 3wk after DLTx with higher proportions of KIR2DL/S1 (p&lt;0.05) and KIR3DL/S1 (p&lt;0.01) positive T cells. Higher activation levels of donor NK and T cells (p&lt;0.001) were detected compared to recipient cells via CD25 expression as well as a higher degranulation capacity upon activation by K562 target cells.ConclusionHigher frequencies of donor NK and T cells expressing KIR compared to recipient NK and T cells argue for their origin in the lung as a part of a highly specialized immunocompetent compartment. Despite KIR expression, higher activation levels of donor NK and T cells in the periphery of recipients suggest their pre-activation during the ex situ phase. Taken together, donor NK and T cells are likely to have a regulatory effect in the balance between tolerance and rejection and, hence, graft survival after DLTx.
Influence of Calcined Bauxite Aggregate on the Resistance of Cement Composites Subjected to Small Caliber Deformable Projectile Impact
Authors: Zhang Fengling , Zhong Rui 
Published: December 2021

This paper presents an experimental investigation on the influence of calcined bauxite aggregate (CBA) on the resistance of cement composites subjected to small caliber deformable projectile impact at a designed velocity of 400 m/s. The deformable projectile was made from copper with a purity of 99.5% and a diameter of 8.0 mm. Compared to mixtures with conventional coarse granite aggregate and/or siliceous fine aggregate, the incorporation of either fine or coarse CBA or their combination is beneficial in reducing the depth of penetration (DOP), equivalent crater diameter (CD), and crater volume (CV) caused by deformable projectile impact. CBA is found to be more effective in controlling the DOP and CV in comparison to the CD. Replacing of conventional aggregate with CBA leads to more severe damage to the projectiles (e.g., projectile length reduction, diameter increase, and mass loss). Relative effective hardness is an effective indicator to the deformation potential and penetration capacity of a deformable projectile to impact cement composites incorporating CBA.