bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finalising the administration of co-SSPedi, a dyad approach to symptom screening for paediatric patients receiving cancer treatments
Authors: Tomlinson Deborah , Schechter Tal , Mairs Mark , Loves Robyn , Herman Daniel , Hopkins Emily , Dupuis L Lee , Sung Lillian 
Published: September 2021

ObjectivesSymptom Screening in Pediatrics Tool (SSPedi) is a validated self-report symptom screening tool for patients with cancer 8–18 years of age. Co-SSPedi is a novel dyad approach in which both child and parent complete SSPedi together. The objective was to finalise the approach to co-SSPedi administration with instruction that is easy to understand, resulting in dyads completing co-SSPedi correctly.MethodWe enrolled child and parent dyads, who understood English and where children (4–18 years) had cancer or were hematopoietic stem cell transplantation recipients. We provided each dyad with instruction on how to complete co-SSPedi together. Mixed methods were used to determine how easy or hard the instruction was to understand. Two raters adjudicated if co-SSPedi was completed correctly. Dyads were enrolled in cohorts of 12 evenly divided by age (4–7, 8–10, 11–14 and 15–18 years).ResultsWe enrolled 5 cohorts of 12 dyads, resulting in 60 dyads. Following verbal instruction provided in the first cohort, we identified the need for written instruction emphasising children should wait for parent response prior to entering scores. The instruction was iteratively refined based on qualitative feedback until the fifth cohort, where all 12 dyads found the instruction easy to understand and completed co-SSPedi correctly.ConclusionsWe developed a standard approach to dyad symptom screening named co-SSPedi with instruction that is easy to understand, resulting in correct co-SSPedi completion. Future efforts should focus on co-SSPedi validation and understanding how co-SSPedi scores compare to self- or proxy-reported symptom reporting.
A maximum caliber approach for continuum path ensembles
Authors: Bolhuis Peter G. , Brotzakis Z. Faidon , Vendruscolo Michele 
Published: September 2021

Abstract
The maximum caliber approach implements the maximum entropy principle for trajectories by maximizing a path entropy under external constraints. The maximum caliber approach can be applied to a diverse set of equilibrium and non-equilibrium problems concerning the properties of trajectories connecting different states of a system. In this review, we recapitulate the basic concepts of the maximum entropy principle and of its maximum caliber implementation for path ensembles, and review recent applications of this approach. In particular, we describe how we recently used this approach to introduce a framework, called here the continuum path ensemble maximum caliber (CoPE-MaxCal) method, to impose kinetic constraints in molecular simulations, for instance to include experimental information about transition rates. Such incorporation of dynamical information can ameliorate inaccuracies of empirical force fields, and lead to improved mechanistic insights. We conclude by offering an outlook for future research.

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A C++ expression system for partial differential equations enables generic simulations of biological hydrodynamics
Authors: Singh Abhinav , Incardona Pietro , Sbalzarini Ivo F. 
Published: September 2021

Abstract
We present a user-friendly and intuitive C++ expression system to implement numerical simulations of continuum biological hydrodynamics. The expression system allows writing simulation programs in near-mathematical notation and makes codes more readable, more compact, and less error-prone. It also cleanly separates the implementation of the partial differential equation model from the implementation of the numerical methods used to discretize it. This allows changing either of them with minimal changes to the source code. The presented expression system is implemented in the high-performance computing platform OpenFPM, supporting simulations that transparently parallelize on multi-processor computer systems. We demonstrate that our expression system makes it easier to write scalable codes for simulating biological hydrodynamics in space and time. We showcase the present framework in numerical simulations of active polar fluids, as well as in classic simulations of fluid dynamics from the incompressible Navier–Stokes equations to Stokes flow in a ball. The presented expression system accelerates scalable simulations of spatio-temporal models that encode the physics and material properties of tissues in order to algorithmically study morphogenesis.

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Comparison of Different HPV-based Strategies and Cytology in Routine Cervical Cancer Screening Programme in China: A Population-based Study
Authors: Wang Shi , Li Ling , Yang Jie , Han Na , Bao Heling , Wang Hai-Jun 
Published: September 2021

Abstract

The study aimed to compare the performance of human papillomavirus (HPV)-based strategies to cytology for detecting cervical intraepithelial neoplasia grade 3 or worse (CIN3+) in routine program in China. The study included 50,434 women ages 30–64 years from January 2015 to December 2019, to assess four strategies: cytology with HPV triage (strategy 1), primary HPV testing with reflex cytology (strategy 2), primary HPV testing with HPV-16/18 genotyping and reflex cytology for non-16–18 high-risk HPV genotypes (strategy 3), and co-testing (strategy 4). The main outcomes were sensitivity for CIN3+ and colposcopy referral rate. Overall, the rates of HPV positivity and cytologic abnormality were 7.0% [95% confidential interval (CI), 6.8–7.2] and 3.5% (95% CI, 3.3–3.6], respectively. The sensitivity for CIN3+ were 88.5% for strategy 4, 83.2% for strategy 3, 64.6% for strategy 1, and 60.1% for strategy 2. The relative sensitivity of strategy 4 and strategy 3 compared with strategy 1 for detecting CIN3+ were 1.38 (95% CI, 1.24–1.54) and 1.29 (95% CI, 1.14–1.46), respectively. The colposcopy referral rates of strategies 4 and 3 were significantly higher than that of strategy 1 (2.4% and 2.2% vs. 1.4%, P &lt; 0.001). In conclusion, co-testing and primary HPV testing with HPV-16/18 genotyping and reflex cytology improved the sensitivity for CIN3+ compared with cytology but increased the colposcopy referral rate. Long-term negative predicted value for HPV-negative women should be studied to determine the screening interval. Our study provides further evidence to the introduction of HPV-based strategies in China.

Prevention Relevance:
Both co-testing and primary HPV testing with HPV-16/18 genotyping and reflex cytology triage provided higher sensitivity for detecting CIN3+; however, the number of colposcopy referrals also increased compared with cytology in a routine program. It has great public health implications for the introduction of HPV-based screening strategies in China.
Modified del Nido versus blood cardioplegia in congenital cardiac surgery
Authors: Sithiamnuai Pitipong , Tocharoenchok Teerapong 
Published: September 2021

Background Lactated Ringer-based del Nido cardioplegia has been reported to be safe for acquired cardiac surgery. The original Plasma-Lyte-based solution has been proved for congenital cardiac surgery but its modification has not been adequately examined. We compared the clinical outcomes of congenital cardiac surgery using lactated Ringer-based del Nido cardioplegia versus cold blood cardioplegia. Methods Between September 2018 and November 2020, 116 consecutive patients with congenital heart disease undergoing operations with cardioplegic arrest performed by a single surgeon at Faculty of Medicine Siriraj hospital; 66 with modified del Nido solution and 50 with institutional's blood cardioplegia. The patient risk profiles, operative details, mortality rates, care durations, inotrope use, blood transfusion and complications were compared. Results Preoperative characteristics were similar between groups, including median age (2.5 vs. 3.1 years; p = 0.49), size, and gender. The Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery score of 3 to 5 was more prevalent in the del Nido group (24.2% vs. 10%; p = 0.049). There were 4 deaths in the modified del Nido group (risk category score of 4) but none in the cold blood group (p = 0.13). There was no significant difference in median intubation duration, length of intensive care unit stay, and vasoactive medications immediately and 24 h after the operation. The del Nido group required 70 to 100 ml less blood transfusion (p = 0.04). All complications were similar between the two groups. Conclusions Clinical outcomes of lactated Ringer-based del Nido cardioplegia were comparable to those of blood cardioplegia in congenital cardiac surgery.
Effects of Prevalent and Newly Diagnosed Arthritis on Changes in Perceived Physical Demands and Work Stress Among Older Workers: Results of a 3 Year Panel Study
Authors: Mutambudzi Miriam , Henkens Kene 
Published: September 2021

Objectives Examine the effects of prevalent and newly diagnosed arthritis on changes in perceived physical demands and general work stress. Methods Conditional change logistic regression models examined the strength of association between arthritis and perceived (1) work stress and (2) physical demands, using data from the NIDI Pension Panel Study ( n = 2099). Results Prevalent and newly diagnosed arthritis were associated with increased odds of perceived work stress and high physical demands. Manual workers with newly diagnosed arthritis exhibited a 6.73-fold (95% CI = 2.87–15.77) increased odds of physical demands. Arthritis in three body extremities was differentially associated with increased odds of work stress and physical demands in manual and non-manual workers. Discussion Prevalent and incident arthritis were associated with changes in work stress and physical demands in older workers. Policies and workplace interventions to reduce stress and physical demands and improve workability in older workers with arthritis are needed.
Novle layered boron nitride nanosheets/cellulose nanofibers/epoxy composite with high thermal conductivity
Authors: Da Yunsheng , He Jing , Qu Qiqi , Zhu Menghan , Wang Hua , Liu Yanyan 
Published: September 2021

Studies have shown that the construction of a three-dimensional interconnected filler network is an effective method to improve the thermal conductivity of the through-plane under a lower filler load. However, huge challenges still exist in building a long-range layered filler network and reducing the thermal resistance resulting from contact between fillers and matrix. In this work, boron nitride nanosheets (BNNSs) were proposed to be connected with modified cellulose nanofibers (CNFs) to obtain a long-range layered structure filler skeleton by bidirectional freezing orientation. Then epoxy resin was dipped under vacuum condition to prepare composite with thermal conductivity up to 1.43 W/mK in through-plane when filler content is 4.3 vol%, and the composite had low thermal expansion coefficient of 64.1 ppm/°C and excellent volume resistivity up to 3.7 × 1012 Ω cm at the same time.
Electroacupuncture inhibits the corneal ROS/TXNIP/NLRP3 signaling pathway in a rat model of dry eye syndrome
Authors: Yang Yanting , Zhang Dan , Wu Lijie , Zhang Ji , Wu Danyan , Li Xiying , Zhi Fangyuan , Yang Guang , Kong Xiehe , Hong Jue , Zhao Yue , Liu Jie , Shi Zheng , Ma Xiaopeng 
Published: September 2021

Background: Electroacupuncture (EA) treatment has been found to ameliorate clinical symptoms in patients with dry eye, but its mechanisms are still not entirely clear. Objective: To study the regulation of EA on ocular surface function and the corneal reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP)/Nod-like receptor protein 3 (NLRP3) inflammatory signaling pathway in dry eye syndrome (DES) model rats. Methods: Male Sprague-Dawley (SD) rats were randomly divided into five groups: Normal, Model, Model + EA, Model + NAC (N-actetylcysteine) and Model + NS (normal saline). The DES model was developed by subcutaneous injection of scopolamine hydrobromide with exposure to an air draft in the latter four groups. After intervention, the Schirmer I test (SIT), tear film break-up time (BUT) and ROS content were measured, the histopathological changes of corneal tissues were observed, and the mRNA and protein expression levels of TXNIP, NLRP3, apoptosis-associated Speck-like protein containing CARD (ASC), caspase-1, interleukin (IL)-1β and IL-18 were detected. Results: Compared with the Model group, the SIT and BUT increased significantly in the Model + EA group after intervention (p < 0.05), and the corneal injury was improved. Corneal ROS content declined in both Model + EA and Model + NAC groups (p < 0.05), and mRNA expression of TXNIP, NLRP3, ASC and caspase-1 also decreased (p < 0.01). Corneal protein expression of TXNIP, NLRP3, IL-1β and IL-18 decreased significantly in the Model + EA group (p < 0.01). Conclusion: Inhibiting the ROS/TXNIP/NLRP3 signaling pathway may be the mechanism underlying the role of EA in improving corneal injury in DES model rats.
The Association Between Racism and Suicidality Among Young Minority Groups: A Systematic Review
Authors: Rudes Giorgia , Fantuzzi Claudia 
Published: September 2021

Introduction: The World Health Organization states that suicide is the second leading cause of death among youngs, and racism has been proven to have detrimental effects on both physical and mental health. These two plagues represent a public health priority, especially for susceptible minorities. Method: This systematic review analyzed 23 studies from multiple database searches, to understand the relationship between racism and suicidality in young minority groups. Results: The review demonstrated the correlation between racism and suicidality with the consequent development of mental disorders. There is strong evidence that the main suicide risk factor is acculturation, interpreted as the assimilation of the dominant culture with the loss of values from one’s cultural background. Discussion: Health care professionals should not underestimate the risk of suicidality associated with racism. Prevention is crucial and it should be implemented from a young age, in schools, through a joint intervention with children and their families, aiming toward integration without acculturation.
Safety and Efficacy of Direct Oral Anticoagulants in Patients With Moderate to Severe Cirrhosis
Authors: Oldham Mildred , Palkimas Surabhi , Hedrick Amanda 
Published: September 2021

Background: Direct oral anticoagulants (DOACs) remain mostly investigational in patients with moderate to severe hepatic cirrhosis, yet are often selected over traditional anticoagulants including warfarin and enoxaparin in this setting. Objective: To determine the safety and efficacy of DOACs in patients with moderate to severe hepatic cirrhosis as compared with traditional anticoagulation. Methods: This was a retrospective, single-center cohort study evaluating inpatients and outpatients who were prescribed a DOAC, warfarin, or enoxaparin for therapeutic anticoagulation with Child-Turcotte-Pugh (CTP) B or C status at the time that the prescription was written. Included patients were followed until first bleeding or thromboembolic event, or until discontinuation of anticoagulation therapy. Data were collected by manual chart review. The primary outcomes included both bleeding events and thromboembolic events in the DOAC population as compared with traditional anticoagulation. Results: A total of 101 patients were included in the study, 69 treated with DOAC therapy and 32 with traditional anticoagulation. Bleeding events occurred in 36% of patients in the DOAC group and 22% of patients in the traditional group ( P = 0.149). In both groups, bleeds were most commonly gastrointestinal. Thromboembolic events occurred in 4% of the DOAC population and no patients in the traditional population ( P = 0.55). No fatal bleeding or thromboembolic events occurred. Conclusion and Relevance: DOACs do not appear to be more harmful than traditional anticoagulation in patients with CTP B or C status. These results support the use of DOACs in patients with CTP B or C hepatic cirrhosis when considering safety, efficacy, and convenience.
Pharmacokinetics, safety and tolerability of single- and multiple-ascending doses of JNJ-64530440, a novel hepatitis B virus capsid assembly modulator, in healthy volunteers
Authors: Kakuda Thomas N , Yogaratnam Jeysen Z , Westland Christopher , Gane Edward J , Schwabe Christian , Vuong Jennifer , Patel Megha , Snoeys Jan , Talloen Willem , Lenz Oliver , Fry John , Chanda Sushmita , van Remoortere Pieter 
Published: September 2021

Background Pharmacokinetics and safety of JNJ-64530440, a hepatitis B virus capsid assembly modulator producing normal empty capsids (CAM-N), in healthy volunteers were evaluated. Methods This Phase I study (NCT03439488) was a double-blind, randomised, placebo-controlled study. Adults ( n = 10/cohort, five Asian/five non-Asian), randomised 4:1, received single-ascending doses of oral JNJ-64530440 (first- and second-generation formulations) or placebo under fasted (50, 150, 300 and 900 mg) or fed (300, 750, 1,000, 2000 and 4000 mg) conditions. Multiple-ascending doses of 750 or 2000 mg once daily and 750 mg twice daily JNJ-64530440 (second-generation formulation) for 7 days were evaluated. Pharmacokinetic parameters were estimated from plasma concentrations. Safety was assessed throughout. Results Less than dose-proportional increases in maximum plasma concentrations (Cmax) and area under the plasma concentration–time curves (AUCs) were observed across the doses. Mean plasma half-lives ranged from 9.3 to 14.5 h. Cmax and AUC were ∼two fold higher under fed versus fasting conditions and slightly higher in Asians versus Caucasians. JNJ-64530440 doses ≥750 mg achieved plasma levels higher than protein-binding adjusted concentrations demonstrating in vitro antiviral activity. No serious adverse events (AEs), treatment discontinuations or dose-limiting toxicities were seen. AE frequency/severity did not increase with dose. Conclusions Single (up to 4000 mg) and multiple doses (up to 2000 mg for 7 days) of JNJ-64530440 were well tolerated in healthy volunteers. Multiple doses ≥750 mg/day achieved plasma concentrations expected to have antiviral activity that may lower hepatitis B surface antigen. No clinically relevant differences in tolerability or pharmacokinetic parameters were seen between Asians versus Caucasians.
Parametric study on mechanical properties of basalt leno textile applied as concrete reinforcement
Authors: Zhang Xiaofei , Wang Xin , Peng Zheqi , Zhu Zhongguo , Wu Zhishen 
Published: September 2021

In this study, the mechanical properties of the basalt leno textile applied as concrete reinforcement were experimentally investigated considering different parameters including the impregnation materials, geometrical characteristics (the number of yarns, yarn structure, and yarn spacing), and loading rate. The tensile strength, elastic modulus, and failure mode were examined. Furthermore, the force mechanism of impregnated leno textile under tensile load was analyzed. The experimental results showed that the textile with a stiff impregnation material exhibited a higher strength and modulus than that with a flexible material. The leno textile with the straight yarn had a better performance than those with the twisted yarns. Besides, the constraint of the weft yarns is obvious to the textile in the warp direction, while the warp yarn makes no contributions to the bearing capacity of textile in the weft direction. The weft yarn spacing had a significant impact on mechanical properties of the textile in the warp direction. Furthermore, the loading rate of approximately 1.2 mm/min was suggested to determine the maximum force of the impregnated basalt leno textile. A tensile strength model was proposed considering the effects of the impregnation material, consistent deformation, torsion damage, and twisted angle.
Knowledge of preconception care and associated factors among maternal health care providers working in urban public health institutions of Eastern Ethiopia
Authors: Sori Seboka Abebe , Teji Roba Kedir , Yadeta Tesfaye Assebe , Jiru Hirut Dinku , Metebo Keyredin Nuriye , Weldekidan Haregwa Asnake , Regassa Lemma Demissie 
Published: September 2021

Background: Provision of preconception care is significantly affected by the health care provider’s knowledge of preconception care. In Ethiopia, preconception care is rare, if even available, as part of maternal health care services. Thus, this study aimed to determine the level of knowledge of preconception care and associated factors among health care providers working in public health facilities in Eastern Ethiopia. Methods: A multicenter cross-sectional study was conducted from 1 March to 1 April 2020. A simple random sampling technique was used to select a total of 415 maternal health care providers. We utilized a structured, pretested, and self-administered questionnaire to collect data. Data were entered into EpiData (version 3.1) and exported to STATA (version 16) for analysis. Descriptive statistics and bivariate and multivariate logistic regression analyses were performed. All covariates with a p value ⩽0.20 in bivariate logistic regression were entered into a multivariate logistic regression analysis to control the confounding variables; variables with a p value <0.05 were considered statistically significant. Results: Out of 410 respondents, 247 (60.2%; 95% confidence interval: 55.4–65.1) had good knowledge of preconception care. Having an educational level of Bachelor of Science degree and above (adjusted odds ratio: 6.97, 95% confidence interval: 3.85–12.60), 5 or more years work experience (adjusted odds ratio: 2.60, 95% confidence interval: 1.52–4.49), working in a hospital (adjusted odds ratio: 2.50, 95% confidence interval: 1.25–4.99), reading preconception care guidelines (adjusted odds ratio: 3.06, 95% confidence interval: 1.40–6.68), and training on preconception (adjusted odds ratio: 2.90, 95% confidence interval: 1.37–6.15) were significantly associated with good knowledge of preconception care. Conclusions and Recommendations: Three out of five maternal health care providers in this study had good knowledge of preconception care. Facilitating continuous refreshment training and continuous professional development for health workers, preparing comprehensive preconception care guidelines for health institutions, and reading preconception care guidelines were highly recommended.