bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytomolecules investigated for the prevention and treatment of urinary stones
Authors: El oumari Fatima Ezzahra , Bousta Dalila , Grafov Andriy , Sqalli Houssaini Tarik 
Published: February 2021

<p class="MTitel">Urolithiasis is a recurrent pathology manifested by the stone formation in the urinary system; it has long been treated in traditional medicine by plant remedies. Several studies have provided the efficacy of medicinal plants as well as their chemical compounds against stone formation. The present work aims to summarize the antiurolithiatic effect of phytochemicals, including quercetin, rutin, catechin, diosmin, and thymoquinone. In this context, various databases, including PubMed, Science Direct, Scopus, and google scholar, were searched using keywords like antiurolithiatic bioactive molecules and chemistry of phytomolecules.</p><p class="MTitel">The results confirmed that phytochemicals, including particularly flavonoid molecules, could be effective against lithogenesis via different strategies such as decreasing the binding between crystals and cells, decreasing the growth of crystals, and increasing magnesium level. Nevertheless, more studies are required, such as determination of toxicity and clinical studies. This review may help researchers achieve more results about the mechanism and the side effects of phytochemicals administration.</p>
Previously Attempted Large Nonpedunculated Colorectal Polyps Are Effectively Managed by Endoscopic Mucosal Resection
Authors: Shahidi Neal , Vosko Sergei , Gupta Sunil , van Hattem W. Arnout , Sidhu Mayenaaz , Tate David J. , Williams Stephen J. , Lee Eric Y.T. , Burgess Nicholas , Bourke Michael J. 
Published: February 2021

INTRODUCTION:
Endoscopic mucosal resection (EMR) is an effective therapy for naive large nonpedunculated colorectal polyps (N-LNPCPs). The best approach for the treatment of previously attempted LNPCPs (PA-LNPCPs) is undetermined.

METHODS:
EMR performance for PA-LNPCPs was evaluated in a prospective observational cohort of LNPCPs ≥20 mm. Efficacy was measured by technical success (removal of all visible polypoid tissue during index EMR) and recurrence at first surveillance colonoscopy (SC1). Safety was assessed by clinically significant intraprocedural bleeding, deep mural injury types III–V, clinically significant post-EMR bleeding, and delayed perforation.

RESULTS:
From January 2012 to October 2019, 158 PA-LNPCPs and 1,134 N-LNPCPs underwent EMR. Median PA-LNPCP size was 30 mm (interquartile range 25–46 mm). Technical success was 93.0% and increased to 95.6% after adjusting for 2-stage EMR. Cold-forceps avulsion with adjuvant snare-tip soft coagulation (CAST) was required for nonlifting polypoid tissue in 73 (46.2%). Median time to SC1 was 6 months (interquartile range 5–7 months). Recurrence occurred in 9 (7.8%). No recurrence was identified among 65 PA-LNPCPs which underwent margin thermal ablation at SC1 vs 9 (18.0%; P < 0.001) which did not. There were significant differences in resection duration (35 vs 25 minutes; P < 0.001), technical success (93.0% vs 96.6%; P = 0.026), and use of CAST (46.2% vs 7.6%; P < 0.001), between PA-LNPCPs and N-LNPCPs. When adjusting for 2-stage EMR, no difference in technical success was identified (95.6% vs 97.8%; P = 0.100). No differences in adverse events or recurrence were identified.

DISCUSSION:
EMR, using auxillary techniques where necessary, can achieve high technical success and low recurrence frequencies for PA-LNPCPs.
The Time Is Now to Understand and Address Sex-Related Disparities in Gastroenterology and Hepatology
Authors: Shaukat Aasma , Oxentenko Amy S. 
Published: February 2021

Abstract
Many gastrointestinal disorders, autoimmune diseases, and pregnancy-related conditions preferentially impact women. This issue of The American Journal of Gastroenterology focuses on women's health in the context of gastrointestinal and liver disease. This editorial highlights the current issue's contents and seeks to spark the conversations to bring awareness to the many issues faced by women as both patients and practitioners.
Anticoagulation and Transjugular Intrahepatic Portosystemic Shunt for the Management of Portal Vein Thrombosis in Cirrhosis: A Prospective Observational Study
Authors: Lv Yong , Bai Wei , Li Kai , Wang Zhengyu , Guo Wengang , Luo Bohan , Wang Jianhong , Wang Qiuhe , Wang Enxin , Xia Dongdong , Li Xiaomei , Yuan Jie , Han Na , Niu Jing , Yin Zhanxin , Fan Daiming , Han Guohong 
Published: February 2021

INTRODUCTION:
Current guidelines recommend anticoagulation as the mainstay of portal vein thrombosis (PVT) treatment in cirrhosis. However, because of the heterogeneity of PVT, anticoagulation alone does not always achieve satisfactory results. This study aimed to prospectively evaluate an individualized management algorithm using a wait-and-see strategy (i.e., no treatment), anticoagulation, and transjugular intrahepatic portosystemic shunt (TIPS) to treat PVT in cirrhosis.

METHODS:
Between February 2014 and June 2018, 396 consecutive patients with cirrhosis with nonmalignant PVT were prospectively included in a tertiary care center, of which 48 patients (12.1%) were untreated, 63 patients (15.9%) underwent anticoagulation, 88 patients (22.2%) underwent TIPS, and 197 patients (49.8%) received TIPS plus post-TIPS anticoagulation. The decision of treatment option mainly depends on the stage of liver disease (symptomatic portal hypertension or not) and degree and extension of thrombus.

RESULTS:
During a median 31.7 months of follow-up period, 312 patients (81.3%) achieved partial (n = 25) or complete (n = 287) recanalization, with 9 (3.1%) having rethrombosis, 64 patients (16.2%) developed major bleeding (anticoagulation-related bleeding in 7 [1.8%]), 88 patients (22.2%) developed overt hepatic encephalopathy, and 100 patients (25.3%) died. In multivariate competing risk regression models, TIPS and anticoagulation were associated with a higher probability of recanalization. Long-term anticoagulation using enoxaparin or rivaroxaban rather than warfarin was associated with a decreased risk of rethrombosis and an improved survival, without increasing the risk of bleeding. However, the presence of complete superior mesenteric vein thrombosis was associated with a lower recanalization rate, increased risk of major bleeding, and poor prognosis.

DISCUSSION:
In patients with cirrhosis with PVT, the individualized treatment algorithm achieves a high-probability recanalization, with low rates of portal hypertensive complications and adverse events.
Predictors of Metachronous Risk Polyps After Index Colonoscopy
Authors: Carot Laura , Navarro Gemma , Naranjo-Hans Dolores , Iglesias-Coma Mar , Dalmases Alba , Fernández Lierni , Seoane Agustín , Buron Andrea , Bellosillo Beatriz , Bessa Xavier , Andreu Montserrat , Alvarez-Urturi Cristina 
Published: February 2021

INTRODUCTION:
Guidelines for surveillance after polypectomy are lacking in strong evidence. Our aim was to identify some precursors of colorectal cancer lesions at 3 years after polypectomy to improve stratification and surveillance programs.

METHODS:
We included patients with high-risk lesions (HRLs), defined as advanced adenoma (AA), large serrated polyps (SPs), and multiplicity (≥3 of any adenomas/SPs). Data on age, sex, cardiovascular risk factors, pharmacological treatment, and the histological characteristics in each individual, and mutations in genes involved in the most advanced index polyp, were collected. Parameters independently associated with a metachronous HRL diagnosis were evaluated through univariate and multivariate analyses. The results are reported as odds ratios and 95% confidence intervals along with P values.

RESULTS:
A total of 537 cases (median age: 60.7 years; 66% male) were included. Dyslipidemia and smoking correlated with metachronous HRLs. Multivariate logistic regression analysis showed that the presence of multiplicity with ≥3 polyps on the index colonoscopy was significantly associated with metachronous HRL, AA, proximal AA, and ≥3 polyps at 3 years. In addition, independent predictors of metachronous proximal AA were increasing age, female sex, and the loss of expression of the MLH1 protein.

DISCUSSION:
Multiplicity was a strong predictor of HRLs at 3 years, although the inclusion of other clinical variables (age, sex, smoking status, and dyslipidemia) improves surveillance recommendations. Without these risk factors, the surveillance could be extended to 5 years; we propose examining the somatic expression of MHL1 in all patients.
Compilation of Commercial Property Price Indices for Germany Tailored for Policy Use
Authors: Knetsch Thomas A. 
Published: February 2021

Abstract
The compilation of commercial property price indices (CPPIs) is challenging. Policymakers urge for timely, reliable and comprehensive data. In Germany, lack of data prevents the calculation of official figures by the national statistical authority. Different applications of price indices need different definitions of commercial real estate. CPPIs according to these definitions are constructed on the basis of existing data for 127 German towns and cities (that cover about one-third of German population). The overall price developments revealed by the various indices are rather similar in terms of central time series characteristics, while differences in detail can be explained by their specific compositions. Price increases for all definitions have been strongest in the seven largest cities. The definitions tend to lead to more marked differences for medium-sized towns.
Do chronic low back pain subgroups derived from dynamic quantitative sensory testing exhibit differing multidimensional profiles?
Authors: Rabey Martin , Kendell Michelle , Koren Shani , Silva Isabela , Watts Lauren , Wong Chris , Slater Helen , Smith Anne , Beales Darren 
Published: February 2021

Abstract

Objectives
The relationship of pain sensitivity with pain and disability in low back pain (LBP) is complicated. It has been suggested increased understanding of dynamic quantitative sensory testing (QST) might be useful in increasing understanding of these relationships. This study aimed to create subgroups based on participant responses to dynamic QST, profile these subgroups based on multidimensional variables (including clinical measures of pain and disability, psychological and lifestyle variables and static QST), and investigate the association of subgroup membership with levels of pain intensity, LBP-related disability and disability risk at 12-month follow up.

Methods
Participants (n=273) with dominant axial chronic non-specific LBP with duration of pain >3 months were included in this study. At baseline, eligible participants completed a self-report questionnaire to collect demographic, clinical, psychological and lifestyle data prior to dynamic and static QST. Dynamic QST measures were conditioned pain modulation (CPM) and temporal summation (TS). At 12-months follow up, clinical data were collected, including pain intensity and LBP-related disability. Sub-groups were formed by cross-tabulation. Analysis was undertaken to profile dynamic QST subgroup on demographic, clinical, psychological, lifestyle and static QST measures. Associations between dynamic QST subgroups and follow-up clinical variables were examined.

Results
Based on dynamic QST, participants were allocated into four subgroups; normal CPM and normal TS (n=34, 12.5%); normal CPM and facilitated TS (n=6, 2.2%); impaired CPM and normal TS (n=186, 68.1%); impaired CPM and facilitated TS (n=47, 17.2%). At baseline no differences were demonstrated between subgroups across most clinical variables, or any psychological or lifestyle measures. The two subgroups with impaired CPM were more likely to have a higher number of painful body areas. Cold pain sensitivity was heightened in both the subgroups with facilitated TS. Subgroups did not differ across pain intensity, LBP-related disability and disability risk stratification at follow-up.

Conclusions
The profiles of people with axial LBP did not vary significantly across dynamic QST subgroups, save for those in groups with impaired CPM being more likely to have more widespread symptoms and those with facilitated TS having heightened cold pain sensitivity. Further, subgroup membership was not related to future pain and disability. The role of dynamic QST profiles in LBP remains unclear. Further work is required to understand the role of pain sensitivity in LBP. The utility of dynamic QST subgrouping might not be in determining of future disability. Future research might focus on treatment modifying effects of dynamic QST subgroups.
Use of Gloves to Examine Intermittent Palm Cooling's Impact on Rowing Ergometry
Authors: O'Brien Ian T. , Kozerski Amy E. , Gray William D. , Chen Ling , Vargas Liliana J. , McEnroe Charles B. , Vanhoover Alexandria C. , King Kristi M. , Pantalos George M. , Caruso John F. 
Published: February 2021

Abstract
O'Brien, IT, Kozerski, AE, Gray, WD, Chen, L, Vargas, LJ, McEnroe, CB, Vanhoover, AC, King, KM, Pantalos, GM, and Caruso, JF. Use of gloves to examine intermittent palm cooling's impact on rowing ergometry. J Strength Cond Res 35(4): 931–940, 2021—The aim of this study was to examine the use of gloves on intermittent palm cooling's impact on rowing ergometry workouts. Our methods had subjects (n = 34) complete 3 rowing ergometer workouts of up to 8 2-minute stages separated by 45- or 60-second rests. They were randomized to one of the following treatments per workout: no palm cooling (NoPC), intermittent palm cooling as they rowed (PCex), or intermittent palm cooling as they rowed and post-exercise (PCex&post). Palm cooling entailed intermittent cold (initial temperature: 8.1° C) application and totaled 10 (PCex) and 20 (PCex&post) minutes, respectively. Workouts began with 8 minutes of rest after which pre-exercise data were obtained, followed by a ten-minute warm-up and the workout, and 20 minutes of post-exercise recovery. Numerous physiological and performance variables were collected before, during, and after workouts, and each was analyzed with either a two- or three-way analysis of variance. Our results include, with a 0.05 alpha and a simple effects post hoc, the distance rowed analysis produced a significant workout effect with PCex, PCex&post > NoPC. There were also significant interworkout differences for heart rate (HR) (NoPC > PCex) and blood lactate concentration (NoPC > PCex, PCex&post). We conclude that lower HRs and blood lactate concentrations from intermittent cooling caused subjects to experience less fatigue during those workouts and enabled more work to be performed. Continued research should identify optimal cooling characteristics to expedite body heat removal. Practical applications suggest that intermittent palm cooling administered with gloves enhance performance by abating physiological markers of fatigue.
Rating of Perceived Exertion and Velocity Relationships Among Trained Males and Females in the Front Squat and Hexagonal Bar Deadlift
Authors: Odgers Johnathan B. , Zourdos Michael C. , Helms Eric R. , Candow Darren G. , Dahlstrom Barclay , Bruno Paul , Sousa Colby A. 
Published: February 2021

Abstract
Odgers, JB, Zourdos, MC, Helms, ER, Candow, DG, Dahlstrom, B, Bruno, P, and Sousa, CA. Rating of perceived exertion and velocity relationships among trained males and females in the front squat and hexagonal bar deadlift. J Strength Cond Res 35(2S): S23–S30, 2021—This study examined the accuracy of intraset rating of perceived exertion (RPE) to predict repetitions in reserve (RIR) during sets to failure at 80% of 1 repetition maximum (1RM) on the front squat and high-handle hexagonal bar deadlift (HHBD). Furthermore, the relationship between RPE and average concentric velocity (ACV) during the sets to failure was also determined. Fourteen males (29 ± 6 years, front squat relative 1RM: 1.78 ± 0.2 kg·kg−1, and HHBD relative 1RM: 3.0 ± 0.1 kg·kg−1) and 13 females (30 ± 5 years, front squat relative 1RM: 1.60 ± 0.2 kg·kg−1, and HHBD relative 1RM: 2.5 ± 0.3 kg·kg−1) visited the laboratory 3 times. The first visit tested 1RM on both exercises. During visits 2 and 3, which were performed in a counterbalanced order, subjects performed 4 sets to failure at 80% of 1RM for both exercises. During each set, subjects verbally indicated when they believed they were at “6” and “9” on the RIR-based RPE scale, and ACV was assessed during every repetition. The difference between the actual and predicted repetitions performed was recorded as the RPE difference (RPEDIFF). The RPEDIFF was significantly (p < 0.001) lower at the called 9 RPE versus the called 6 RPE in the front squat for males (9 RPE: 0.09 ± 0.19 versus 6 RPE: 0.71 ± 0.70) and females (9 RPE: 0.19 ± 0.36 versus 6 RPE: 0.86 ± 0.88) and in the HHBD for males (9 RPE: 0.25 ± 0.46 versus 6 RPE: 1.00 ± 1.12) and females (9 RPE: 0.21 ± 0.44 versus 6 RPE: 1.19 ± 1.16). Significant inverse relationships existed between RPE and ACV during both exercises (r = −0.98 to −1.00). These results indicate that well-trained males and females can gauge intraset RPE accurately during moderate repetition sets on the front squat and HHBD.
Repetitions in Reserve Is a Reliable Tool for Prescribing Resistance Training Load
Authors: Lovegrove Simon , Hughes Liam J. , Mansfield Sean K. , Read Paul J. , Price Phil , Patterson Stephen D. 
Published: February 2021

Abstract
Lovegrove, S, Hughes, L, Mansfield, S, Read, P, Price, P, and Patterson, SD. Repetitions in reserve is a reliable tool for prescribing resistance training load. J Strength Cond Res 36(10): 2696–2700, 2022—This study investigated the reliability of repetitions in reserve (RIR) as a method for prescribing resistance training load for the deadlift and bench press exercises. Fifteen novice trained men (age: 17.3 ± 0.9 years, height: 176.0 ± 8.8 cm, body mass: 71.3 ± 10.7 kg) were assessed for 1 repetition maximum (1RM) for deadlift (118.1 ± 27.3 kg) and bench press (58.2 ± 18.6 kg). Subsequently, they completed 3 identical sessions (one familiarization session and 2 testing sessions) comprising sets of 3, 5, and 8 repetitions. For each repetition scheme, the load was progressively increased in successive sets until subjects felt they reached 1-RIR at the end of the set. Test-retest reliability of load prescription between the 2 testing sessions was determined using intraclass correlation coefficient (ICC) and coefficient of variation (CV). A 2-way analysis of variance with repeated measures was used for each exercise to assess differences in the load corresponding to 1-RIR within each repetition scheme. All test-retest comparisons demonstrated a high level of reliability (deadlift: ICC = 0.95–0.99, CV = 2.7–5.7% and bench press: ICC = 0.97–0.99, CV = 3.8–6.2%). Although there were no differences between time points, there was a difference for load corresponding to 1-RIR across the 3 repetition schemes (deadlift: 88.2, 84.3, and 79.2% 1RM; bench press: 93.0, 87.3, and 79.6% 1RM for the 3-, 5-, and 8-repetition sets, respectively). These results suggest that RIR is a reliable tool for load prescription in a young novice population. Furthermore, the between-repetition scheme differences highlight that practitioners can effectively manipulate load and volume (repetitions in a set) throughout a training program to target specific resistance training adaptations.
Validation of Internal and External Load Metrics in NCAA D1 Women's Beach Volleyball
Authors: Tometz Matthew J. , Jevas Stephanie A. , Esposito Philip M. , Annaccone Adam R. 
Published: February 2021

Abstract
Tometz, MJ, Jevas, SA, Esposito, PM, and Annaccone, AR. Validation of internal and external load metrics in NCAA D1 women's beach volleyball. J Strength Cond Res 36(8): 2223–2229, 2022—The purpose of this study was to determine the validity of internal and external load metrics in NCAA D1 women's beach volleyball. Subjects included 13 NCAA D1 women's beach volleyball players (age: 20.3 ± 1.4 years). A total of 578 data points were analyzed from 51 team training sessions, including practice, games, and sport-specific conditioning during the pre-season semester (15 weeks). Data points included Edward's training impulse (TRIMP) (228.0 ± 80.7 arbitrary units [AU]), session rating of perceived exertion (sRPE) Load (532.5 ± 232.8 [AU]), distance covered (DC) in meters (2,635.4 ± 884.3 [m]), and daily environmental condition variables {(temperature (76.5 ± 13.7 [°F]), relative humidity (72.5 ± 13.2 [%]), and wet-bulb globe temperature (52.9 ± 19.9 [°F])}. The subjects wore Polar Team Pro heart rate monitors with global positioning system during each session. Subjects completed an sRPE questionnaire after every session. Pearson product moment correlations yielded statistically significant relationships (p < 0.01) between TRIMP and sRPE Load (r = 0.81), TRIMP and DC (r = 0.78), and sRPE Load and DC (r = 0.82). A forward selection multiple regression yielded that sRPE Load could predict TRIMP with the equation: TRIMPTometz = 78.735 + (sRPE Load * 0.28) (p < 0.001). These findings support sRPE Load as a valid alternative to TRIMP when monitoring internal loads in NCAA D1 women's beach volleyball. Session rating of perceived exertion Load may be more practical and accessible for teams. Distance covered should be considered when periodizing and monitoring training loads because of its relationship with internal loads.
Using High-Volume Warm-Ups to Improve Performance in Paralympic Throwers
Authors: Judge Lawrence W. , Brown Nate , Schoeff Makenzie A. , Bellar David M. , Craig Bruce W. 
Published: February 2021

ABSTRACT
The chronic effects of the asymmetrical biomechanical demands placed on the body of Paralympic throwers stress the importance of proper preparation. The usage of high-volume preactivity warm-ups has generated a great deal of interest within the strength and conditioning community. However, it has not been used with Paralympic throwers. This column will examine the applicability of a high-volume preactivity warm-up for Paralympic track and field throwers.
El calamar de los tentáculos de oro. Un análisis de la pesca china en Perú (2000-2020)
Authors: Ortega Federico , Saavedra Darío , Esquiroz Federico 
Published: February 2021

Las flotas de pesqueros de capitales chinos extraen recursos a escala global en los océanos del mundo para abastecer a su creciente mercado interno de productos marítimos, como el calamar gigante Dosydicus gigas. Al igual que el gigante asiático, otras potencias en el rubro llevan a cabo una explotación de tinte extractivista sobre las aguas internacionales adyacentes a las jurisdicciones de países ribereños como el Perú y en todos los mares del mundo, alimentados por generosos subsidios estatales. Esto no evita que, en ocasiones, las flotas incurran en prácticas como la pesca ilegal, no declarada, no reglamentada y la explotación de trabajadores, con el peligro latente de la sobreexplotación de los recursos marítimos, y los perjuicios tanto para la biodiversidad como para al ecosistema que esto conlleva. El proceso se complementa con la inserción en el circuito legal de la pesca, en este caso, en el Perú, mediante fusiones y adquisiciones de varias compañías del rubro.
En el contexto de estas prácticas extractivistas, y en el marco de una guerra mundial, híbrida y fragmentada, se desarrolla un conflicto por el control del Pacífico Sur entre China y los Estados Unidos, en la cual el Gobierno norteamericano encabeza acciones y críticas contra las políticas chinas, usando el discurso de varias Organizaciones No Gubernamentales. Las acciones y posturas de ambos bandos tienen implicancias geoestratégicas, que tuvieron un pico con la aparición de las flotas chinas en el Pacífico Sur durante los meses de agosto a octubre del 2020.