bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of biological activities of highly diluted nucleotide sequences by using cellular models
Authors: Capieaux Etienne , Alsaleh Ghada , Borde ChloÃƒÆ’Ã‚Â© , Wachsmann Dominique , MarÃƒÆ’Ã‚Â©chal Vincent , Dorfman Pierre 
Published: December 2021

Background: highly diluted specific nucleic acids (SNAÃƒâ€šÃ‚Â®), designed to modulate viral and cytokine genes expression, are currently used in Micro-Immunotherapy to treat viral infections and immune disorders. Although some preliminary studies have showed clinical benefit of these homeopathic preparations [1], no experimental data are available to explain their mechanism of action.
Aims: to investigate the in vitro effect of two sets of highly diluted (HD) SNA targeting i) latent/lytic Epstein-Barr virus (SNA EBV) and ii) TNF-ÃƒÅ½Ã‚Â± and its receptor p55 involved in rheumatoid arthritis (SNA RA) on cellular models.
Methodology: serial homeopathic dilutions of SNA EBV and SNA RA (15cH-18cH) were tested on a EBV-positive B-lymphoblastoid (B95-8) and on a LPS-stimulated macrophage (THP1) cell lines respectively, in comparison with agitated/diluted water and scramble DNA sequences prepared in the same conditions (negative controls). For B95-8 proliferative model, high mobility group box 1 protein (HMGB1) was used as reference. Analyzed biological parameters on B95-8 were i) cell proliferation measured after 24 and 48h of incubation with HD SNA and ii) expression of the EBV ZEBRA protein in response to TGF-ÃƒÅ½Ã‚Â² by Western-blotting (T+24h). For THP1 model, TNF-ÃƒÅ½Ã‚Â± synthesis and release were determined by RT-qPCR and ELISA (protein), after stimulation by LPS (1Ãƒâ€šÃ‚Âµg/ml) and HD SNA co-administration.
Results: we demonstrated that HD SNA RA significantly down-regulated TNF-ÃƒÅ½Ã‚Â± synthesis and release. This biological activity was showed to be specific (no effect of HD scramble SNA) and related to the level of dilution (maximal effect with higher dilutions). Unexpectedly, a biological effect of agitated/diluted water was also detected in both cellular models. For B95-8 model, this effect resulted in a significant decrease of B95-8 proliferation (comparable to the HMGB1 reference) and an inhibition of ZEBRA expression. Similarly, a reproducible stimulation effect of HD water was obtained in the LPS-stimulated THP1 model.
Conclusions: these findings indicate that highly diluted SNA RA can regulate TNF-ÃƒÅ½Ã‚Â± synthesis and release by LPS-stimulated THP1 and support the hypothesis that these homeopathic preparations may act in modulating mRNA expression of the targeted genes. This in vitro work underlines the potential effect of agitated water in context of cellular models for testing biological properties of HD.

[1] Jenaer M, Henry MF, Garcia A, Marichal B. Evaluation of 2LHERP in preventing recurrences of genital herpes. Br Homeopath J. 2000 Oct;89(4):174-7.
Hydroclimatic variability of opposing Late Pleistocene climates in the Levant revealed by deep Dead Sea sediments
Authors: Ben Dor Yoav , Marra Francesco , Armon Moshe , Enzel Yehouda , Brauer Achim , Schwab Markus Julius , Morin Efrat 
Published: December 2021

Abstract. Annual and decadal-scale hydroclimatic variability
describes key characteristics that are embedded into climate in situ and is
of prime importance in subtropical regions. The study of
hydroclimatic variability is therefore crucial to understand its
manifestation and implications for climate derivatives such as hydrological
phenomena and water availability. However, the study of this variability
from modern records is limited due to their relatively short span, whereas
model simulations relying on modern dynamics could misrepresent some of its
aspects. Here we study annual to decadal hydroclimatic variability in the
Levant using two sedimentary sections covering ∼ 700 years
each, from the depocenter of the Dead Sea, which has been continuously
recording environmental conditions since the Pleistocene. We focus on two
series of annually deposited laminated intervals (i.e., varves) that
represent two episodes of opposing mean climates, deposited during MIS2
lake-level rise and fall at ∼ 27 and 18 ka,
respectively. These two series comprise alternations of authigenic aragonite
that precipitated during summer and flood-borne detrital laminae deposited
by winter floods. Within this record, aragonite laminae form a proxy of
annual inflow and the extent of epilimnion dilution, whereas detrital
laminae are comprised of sub-laminae deposited by individual flooding
events. The two series depict distinct characteristics with increased mean
and variance of annual inflow and flood frequency during “wetter”, with
respect to the relatively “dryer”, conditions, reflected by opposite
lake-level changes. In addition, decades of intense flood frequency
(clusters) are identified, reflecting the in situ impact of shifting
centennial-scale climate regimes, which are particularly pronounced during
wetter conditions. The combined application of multiple time series analyses
suggests that the studied episodes are characterized by weak and
non-significant cyclical components of sub-decadal frequencies. The
interpretation of these observations using modern synoptic-scale
hydroclimatology suggests that Pleistocene climate changes resulted in
shifts in the dominance of the key synoptic systems that govern rainfall,
annual inflow and flood frequency in the eastern Mediterranean Sea over
centennial timescales.
Strategic Priorities, Management Competencies, and Performance of the Divisions of Schools in Negros Island, Philippines
Authors: Temprosa Mary Ann M. 
Published: December 2021

Good governance is a requisite in achieving quality education and lifelong learning. This combined descriptive, comparative, and correlative study looked into the strategic priorities, management competencies, and performance of the 16 divisions of schools in the Department of Education in Negros Island, Philippines. The statistical tools used were percentage and mean to determine their strategic priorities, management competencies, and performance based on the study's indicators; single-factor analysis of variance to find out any significant difference in their strategic priorities and management competencies; and Spearman rho to examine the coefficient of correlation between their strategic priorities and management competencies, their strategic priorities and performance, and their management competencies and performance. The study found no significant difference between the divisions of schools’ strategic priorities and management competencies, and no significant relationship between these variables and between these variables and their performance.
La gestión del patrimonio en el ámbito rural: el caso de la serranía celtibérica
Authors: Chordá Marta , Cerdeño María Luisa 
Published: December 2021

El Patrimonio Cultural ubicado en zonas rurales comparte los mismos problemas que el resto, con el factor añadido del olvido y, como consecuencia, del abandono. Sin embargo, constituye un campo de acción, reflexión y dinamización cuya pérdida no puede permitirse en el actual contexto de crisis. Es el caso de los territorios interiores, especialmente los coincidentes con los límites de la Celtiberia histórica, que se han convertido en la zona cero de la despoblación en Europa. Ello supone un grave problema socioeconómico, así como una desprotección sin precedentes del paisaje, con la pérdida de los bienes patrimoniales allí conservados. El Patrimonio Rural es variado, arqueológico, etnográfico, inmaterial y natural, pero los proyectos iniciados hace años ya no son sostenibles por falta de inversión pública y también por el exceso de expectativas en el binomio patrimonio-turismo. El análisis de la actividad científica y arqueológica en las zonas rurales bajo la perspectiva de los Objetivos de Desarrollo Sostenible abre las puertas para retomar estos esfuerzos por parte de los agentes sociales. En este artículo se hace un recorrido por la situación actual de ese patrimonio y su investigación, señalando las amenazas a las que se enfrenta y también las oportunidades de futuro.
<span>Định l&iacute; điểm bất động cho &aacute;nh xạ hầu co-(&psi; ,ϕ) tổng qu&aacute;t trong kh&ocirc;ng gian b-m&ecirc;tric</span>
Authors: Nguyễn Thành Nghĩa , Nguyễn Trung Hiếu 
Published: December 2021

Trong bài báo, chúng tôi giới thiệu khái niệm ánh xạ hầu co-(ψ ,ϕ) tổng quát trong không gian b-mêtric sắp thứ tự bằng cách bổ sung thêm bốn số hạng d(f2x,fx), d(f2x,y), d(f2x,fy) và d(f2x,x)+d(f2x,fy)2s thiết lập định lí điểm bất động cho lớp ánh xạ co này. Đồng thời, chúng tôi xây dựng một số ví dụ minh họa cho kết quả đạt được.
A short note on the BMI and on secular changes in BMI
Authors: Mumm Rebekka , Hermanussen Michael 
Published: December 2021

Human size changes over time with worldwide secular trends in height, weight, and body mass index (BMI). There is general agreement to relate the state of nutrition to height and weight, and to ratios of weight-to-height. The BMI is a ratio. It is commonly used to classify underweight, overweight and obesity in adults. Yet, the BMI is inappropriate to provide any immediate information on body composition.
It is accepted that the BMI is “a simple index to classify underweight, overweight and obesity in adults”. It is stated that “policies, programmes and investments need to be “nutrition-sensitive”, which means they must have positive impacts on nutrition”. It is also stated that “a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions“. But these statements are neither warranted by arithmetic considerations, nor by historic evidence.
Measuring the BMI is an appropriate screening tool for detecting an unusual weight-to-height ratio, but the BMI is an inappropriate tool for estimating body composition, or suggesting medical and health policy decisions.
Stunting does not impair physical fitness in Indonesian school children
Authors: Scheffler Christiane , Hermanussen Michael 
Published: December 2021

Background
Physical fitness is decreased in malnourished children and adults. Poor appearance and muscular flaccidity are among the first signs of malnutrition. Malnutrition is often associated with stunting.
Objectives
We test the hypotheses that stunted children of low social strata are physically less fit than children of high social strata.
Sample
We investigated 354 school girls and 369 school boys aged 5.83 to 13.83 (mean 9.54) years from three different social strata in Kupang (West-Timor, Indonesia) in 2020.
Methods
We measured height, weight, and elbow breadth, calculated standard deviation (SDS) of height and weight according to CDC references, and the Frame index as an indicator of long-term physical fitness, and we tested physical fitness in standing long jump and hand grip strength.
Results
Children of low social strata are physically fittest. They jump longer distances, and they have higher values in the Frame index. No association exists between height SDS and physical fitness, neither in respect to standing long jump, nor to hand grip strength.
Conclusion
Stunting does not impair physical fitness in Indonesian school children. Our results support the concept that SEPE (social-economic-political-emotional) factors are involved in the regulation of human growth.
Greater central adiposity resulting from increased market integration is associated with elevated C-reactive protein levels in older women from the Republic of Vanuatu
Authors: Mann Hayley , Pomer Alysa , Olszowy Kathryn , Sun Cheng , Silverman Harold , Dancause Kelsey , Chan Chim , Tarivonda Len , Taleo George , Kaneko Akira , Weitz Charles , Garruto Ralph , Lum Jefrey 
Published: December 2021

Objective: We characterized the relationship between circulating C-reactive protein (CRP) levels and nine anthropometric measures of body fat to identify the best anthropometric predictors of CRP in Ni-Vanuatu women.
Sample and Methods: Anthropometric data and blood spot samples were collected from sixty-four Ni-Vanuatu female participants (age 35-78 years) on five islands with varying degrees of market integration, cultural change, and obesity. CRP concentration was determined with a high-sensitivity ELISA (hsCRP) assay and then compared to nine different anthropometric measurements.
Results: BMI was significantly correlated with CRP (p=0.047). Among the eight additional anthropometrics, the suprailiac skinfold (p=0.003) and waist-circumference (p=0.009) were better predictors of CRP than BMI. Moreover, our stepwise selection model indicated that the suprailiac skinfold explained ~14% of CRP level variance.
Conclusions: The BMI-CRP correlation coefficient for Ni-Vanuatu women falls within the range of previously reported values for East Asian populations with whom they share genetic ancestry. However, the best anthropometric predictors of CRP levels were waist circumference and suprailiac skinfold thickness. These measures capture central adiposity and are more closely associated with elevated CRP level and cardiovascular disease risk than fat distributed elsewhere on the body. Ni-Vanuatu in urban settings with high market integration are at greater risk for obesity, which is associated with elevated CRP levels. However, because nearly all Ni-Vanuatu still retain horticultural knowledge and land ownership, consumption of processed, imported foods is largely determined by degree of market integration and personal choice. Therefore, health interventions focusing on sustainable traditional food practices are feasible.
SIKAP PETUGAS TERHADAP PENGISIAN REKAM MEDIS RAWAT INAP DI RUMAH SAKIT SINAR HUSNI TAHUN 2017
Authors: Sabela Hasibuan Ali , W Siburian Melita 
Published: December 2021

Rekam medis tidak hanya sekeda rmempunyai pengertian sebagai kegiatan pencatatan saja, akan tetapi mempunyai pengertian sebagai suatu system penyelenggaraan rekam medis penelitian ini bertujuan untuk mengetahui bagaimana sikap petugas rekam medis tentang system pengisian di Rumah Sakit Umum Sinar Husni Medan. Sikap petugas rekam medis adalah suatu kinerja secara kualitas dan kuantitas yang dicapai oleh petugas dalam melaksanakan tugasnya sesuai dengan tanggung jawab yang diberikan. Dalam mencapai kinerja yang maksimal diperlukan sistem reward sebagai dorongan atau motivasi seseorang dalam bekerja. Reward adalah insentif positif yang berupa penghargaan, anugerah, dan imbalan akibat hasil kerja yang baik yang dilakukan karyawan. Metode penelitian ini menggunakan kuantitatif. Populasi dalam penelitian ini adalah seluruh petugas rekam medis di unit rekam medis RSU SinarHusni Medan, sampel diambil menggunakan teknik total sampling berjumlah 6orang. Hasil Penelitian menunjukkan bahwa petugas dengan kinerja yang sangatbaik 2 orang (33,3), petugas yang tetapi kinerja baik sebanyak 4 orang (66,7%). Untuk itu disarankan kepada perekam medis agar lebih meningkatkan sikap petugas yang tercakup dalam penyelenggaraan pelayanan rekam medis di RSU Sinar Husni Medan.
ANALISA KEBUTUHAN RAK PENYIMPANAN BERKAS REKAM MEDIS RAWAT JALAN DI RUMAH SAKIT UMUM MADANI MEDAN
Authors: Andi Ritonga Zulham , Aisah Ritonga Nur 
Published: December 2021

Rak penyimpanan merupakan salah satu peralatan rumah sakit yang berfungsi menyimpan dokumen rekam medis, dengan tersedianya rak penyimpanan dokumen rekam medis yang sesuai dengan kapasitas penyimpanan dokumen rekam medis maka tidak akan terjadi penumpukan dokumen di Lantai. Penelitian ini bertujuan untuk mengetahui perkiraan kebutuhan rak penyimpanan dokumen rekam medis rawat jalan di Rumah Sakit Umum Madani Medan Tahun 2018. Penelitian ini menggunakan metode deskriptif kuantitatif yaitu dengan memaparkan hasil penelitian apa adanya dan membandingkan dengan teori yang kemudian diambil kesimpulan. Waktu penelitian dilaksanakan pada bulan Oktober 2017-Januari 2018 di Rumah Sakit Umum Madani Medan. Populasi dan sampel yang digunakan adalah rak penyimpanan dan dokumen rekam medis rawat jalan. Instrumen yang digunakan dalam pengumpulan data antara lain dengan observasi dan wawancara. Hasil penelitian ini menunjukkan bahwa jumlah kunjungan pasien rawat jalan di Rumah Sakit Umum Madani Medan dari tahun 2014 – 2016 sebanyak 52.439. Jumlah rak penyimpanan rekam medis rawat jalan di Rumah Sakit Umum Madani Medan sebanyak 7 rak. Jika saat ini rumah sakit memiliki 7 rak file, maka rumah sakit perlu menyediakan 4 rak file lagi agar kebutuhan rak dapat tercukupi dan dapat menampung semua berkas rekam medis pasien secara sistematis dan tidak menyulitkan petugas dalam proses penyimpanan dan pencarian berkas rekam medis pasien.
TINJAUAN PELAKSANAAN KARS 2012 MKI 16 BERDASARKAN SPO DI RSU IMELDA PEKERJA INDONESIA MEDAN TAHUN 2018
Authors: Sabela Hasibuan Ali , Kartika Pulungan Nidiya 
Published: December 2021

Standar MKI 16 menjelaskan bahwa dokumen rekam medis harus dilindungi dari kehilangan dan kerusakan serta akses dan penggunaan oleh yang tidak berhak. Berdasarkan survey awal diketahui dari 23. 934 dokumen rekam medis masih dijumpai 15% persentase berkas yang hilang dan rusak. Penelitian ini dilakukan untuk mengetahui pelaksanaan MKI 16 Berdasarkan SPO di Rumah Sakit Imelda Pekerja Indonesia.Metode penelitian adalah deskriptif dengan metode observasi dan lembar cheklist. Pengumpulan data melalui observasi dan lembar cheklist terhadap SPO yang ada di Rumah Sakit Umum Imelda Pekerja Indonesia.Hasil penelitian ini menunjukkan bahwa kepatuhan petugas rekam medis terhadap standar prosedur operasional (SPO) MKI 16 sudah sesuai dengan pekerjaan yang dilakukan petugas rekam medis, namum petugas masih membiarkan DRM tercecer atau berserajan di lantai ruang filling. Sebaiknya perlu dilakukan untuk kerapian penyimpanan DRM petugas rekam medis agar lebih memperhatikan kerapian DRM rekam medis.
PERANCANGAN SISTEM INFORMASI PENDAFTARAN PASIEN RAWAT JALAN BERBASIS VISUAL BASIC DI RUMAH SAKIT IMELDA PEKERJA MEDAN
Authors: Sofyan  , Bahar Harahap Khatika 
Published: December 2021

Rekam medis elektronik merupakan catatan rekam medik pasien seumur hidup dalam format elektronik tentang kesehatan seseorang yang dituliskan oleh satu atau lebih petugas kesehatan secara terpadu dalam tiap kali pertemuan anatar petugas kesehatan dengan klien. Tujuan penelitian ini adalah untuk mengetahui bagaimana perancangan sistem informasi pendaftaran pasien rawat jalan dirumah sakit imelda pekerja indonesia serta untuk mengetahui alur dan kurangan dalam pelaksanaan rekam medisyang terkomputerisasi. Jenis penelitian ini adalah STRADIS (Structur Analysis Design and implementation of Information System) bertujuan melakukan pengembangan tools dalam perancangan sistem dengan menggunaan Data Flow Diagram(DFD).Dalam melakukan penelitian, peneliti melakukan observasi terhadap alur pendaftarara pasien dan menggambil sampel sebanyak 20 pegawaipendaftaran pasien. Berdasarkan hasil penelitian yang dilakukan di RSU Imelda Pekerja Indonesia pelaksanaan pendaftaran pasien rawat jalan masih belum bejalan dengan baik dilihat dari observasi yang dilakukan peneliti masih belum terlaksananya pemeberian nomor antrian setiap melakukan pendaftaran dan kekurangan lainya pada jaringan saat melakukan Proses penyimpanan atau pencarian. Kesimpulannya perancangan sistem informasi pendaftaran pasien rawat jalan dapat berjalan sesuai kebutuhan namun alur dan penggunaan kompueterisasi lebih diperhatikan sesuai kebutuhan rumah sakit.
TINJAUAN PENATALAKSANAAN PROGRAM INDONESIA SEHAT DENGAN PENDEKATAN KELUARGA (PIS-PK) PADA PUSKESMAS TEGAL SARI TAHUN 2019
Authors: Noviar Panggabean Terry 
Published: December 2021

ABSTRAK

Di dalam hakekatnya pembangunan kesehatan merupakan berbagai usaha ataupun upaya yang dilaksanakan oleh setiap Individu Bangsa Indonesia dalam tujuan meningkatkan kesadaran masyarakat indonesia, kemauan, serta kemampuan hidup yang sehat bagi setiap individu Bangasa Indonesia agar terwujud tingginya derajat kesehatan masyarakat, yang juga merupakan suatu investasi bagi pembangunan sumber daya manusia yang produktif secara sosial dan ekonomis. Tujuan penelitian ini untuk mengetahui sejauh mana penatalaksanaan program indonesia sehat pada puskesmas tegal sari. Jenis penelitian menggunakan metode deskriptif. Waktu penelitian dilakukan pada bulan Maret sampai Mei 2019 dan penelitian dilakukan di Puskesmas Tegal Sari Medan. Data dikumpulkan dengan menggunakan observasi. Hasil penelitian menunjukkan Data yang terkumpul hingga saat ini adalah 5.500 keluarga, dan data yang dientri dalam aplikasi keluarga sehat sebanyak 3.762 keluarga. Sedangkan banyak keluarga dalam area kerja Puskesmas Tegal Sari sebanyak 7.483 keluarga. Disarankan kepada pihak Puskesmas menambah jumlah SDM dan Sarana dalam pengerjaan program ini, memperbaiki jaringan koneksi internet.

ABSTRACT

In the essence of health development is a variety of efforts or efforts undertaken by each individual nation of Indonesia in the goal of raising Indonesian society awareness, willingness, and healthy living ability for every Individuals of Indonesian nation to materialize the high degree of public health, which is also an investment in the development of human resources that are socially and economically productive. The purpose of this research is to know the extent of the management of healthy Indonesian programs at Puskesmas Tegal Sari. This type of research uses descriptive methods. Research time is conducted in March to May 2019 and research conducted at the Puskesmas of Tegal Sari Medan. Data is collected using observation. The results of the study show that the Data gathered to date is 5,500 families, and the data that is included in the family application is as much as 3,762 families. While many families in the work area of Tegal Sari Puskesmas as much as 7,483 families. Recommended to the Puskesmas increase the number of human resources and facilities in the work of this program, repair the network Internet connection.
GAMBARAN SISTEM RUJUKAN TERINTEGRASI (SISRUTE) DI RSUD Dr. RM DJOELHAM BINJAI TAHUN 2019
Authors: Junita Bancin Lamtiur , Putri Nurul Arrizka , Rahmayani Nurul , Kharisma Ransiska , Purba Silvi Widya 
Published: December 2021

Sistem Rujukan Terintegrasi (Sisrute) merupakan sebuah aplikasi untuk penyelenggaraan pelayanan kesehatan antar Fasilitas kesehatan. Sisrute Pelayanan kesehatan tingkat rujukan terdiri atas fasilitas kesehatan sekunder dan tersier. Sisrute mempunyai fungsi dalam menbantu perumusan kebijakan strategis dan teknis dibidang kesehatan rujukan yang berkesinambungan dan mendukung penyelenggaraan pemerintahan daerah di bidang kesehatan. Adapun tujuan dari penelitian ini adalah untuk mengetahui alur Sisrute, kendala dan kelebihan dari aplikasi Sisrute di RSUD Dr.RM Djoelham Binjai. Jenis penelitian adalah penelitian deskriptif. Sumber data yang digunakan adalah data sekunder yang sudah ada di rumah sakit. Dalam penelitian ini analisa data dilakukan secara deskriptif melalui observasi, penyajian dan penarikan kesimpulan, sehingga diperoleh gambaran tentang Sisrute. Aplikasi Sisrute sangat membantu percepatan pelayanan, memudahkan informasi rujukan terkait kejelasan pasien dapat diterima oleh RS yang dirujuk, mudah melakukan konsultasi dalam penanganan pasien lebih terarah dan meminimalkan penolakan pasien dengan koordinasi dan komunikasi antara RSUD Dr. RM Djoelham Binjai dengan RS yang ingin dirujuk/RS penerima. Kendala penggunaan Sisrute yaitu: Server Internet tidak stabil dan data-data pasien yang dirujuk tidak lengkap sesuai dengan form yang ada di sistem sehingga menyulitkan RS penerima menerima jawaban. Kelebihan penggunaan Sisrute yaitu yaitu perujuk bisa mengetahui tujuan Rumah Sakit sesuai kebutuhan pasien, memastikan pasien sudah mendapatkan perawatan dari RS yang dirujuk, perujuk bisa dapat kepastian terhadap pasien yang akan dirujuk.