bluuebunny/crossref_metadata_2025_split huggingface dataset:
NOD1, NOD2, PYDC1, and PYDC2 gene polymorphisms in ovarian endometriosis
Authors: Kula Hakan , Balbal Beste , Timur Tunc , Yalcın Pelin , Yavuz Onur , Kızıldag Sefa , Ulukus Emine Cagnur , Posaci Cemal 
Published: February 2025

BackgroundEndometriosis, a prevalent chronic gynecologic disorder, significantly impacts women’s health, with both genetic and environmental factors contributing to its heritability. Within the adaptive immune system, the NOD-like receptors (NLR) pathway plays pivotal roles in various autoinflammatory diseases, regulating interleukins, proinflammatory cytokines, and NF-κB activity. However, the potential association between single nucleotide polymorphisms (SNPs) of the NOD1, NOD2, PYDC1, and PYDC2 genes and the predisposition to endometriosis risk remains unexplored.MethodsIn this cross-sectional study, 54 patients diagnosed with ovarian endometriosis and 54 control subjects were included. The genetic SNPs of NOD1 (rs2075820 and rs2075818) and NOD2 (rs104895461) were assessed using the PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) method. Additionally, the polymorphisms of PYDC1 and PYDC2 were evaluated using Sanger sequencing. After conducting polymorphism analysis, the genetic profiles were assessed with the clinical manifestations and the size of ovarian endometriomas, categorized as either small (&lt;4 cm) or large (≥4 cm).ResultsSignificant differences in the NOD1 rs2075820 (G: A) genotypes were found. The GG genotype was more prevalent in endometriosis patients (p = 0.04), while the GA genotype was less common (p = 0.029). The AA genotype was associated with higher rates of perimenstrual gastrointestinal symptoms (p = 0.005) and infertility (p = 0.037). The PYDC2 rs293833 variant was detected in 22.2% of patients. Carriers of this variant exhibited higher rates of perimenstrual gastrointestinal symptoms (p = 0.004), infertility (p = 0.001) and larger endometriomas (≥4 cm) (p &lt; 0.001). No significant differences were found in NOD1 rs2075818 genotypes (p = 0.89) and no polymorphisms were detected in NOD2 or PYDC1 genes.ConclusionThese findings emphasize the influence of genetic polymorphisms on the clinical manifestations of endometriosis. Specifically, gene polymorphisms in NLRs have been found to significantly impact infertility and increase endometrioma size.
HTLV-1 and HTLV-2 infections significantly alter small RNA expression in asymptomatic carriers
Authors: Fernandes Lorena Abreu , Folgosi Victor Ângelo , Pessôa Rodrigo , Assone Tatiane , Victor Jefferson Russo , Casseb Jorge , de Oliveira Augusto César Penalva , Nukui Youko , da Silva Duarte Alberto José , Sanabani Sabri Saeed 
Published: February 2025

IntroductionThis study investigates the impact of HTLV-2 infection on small RNA (sRNA) expression profiles, building on previous findings related to HTLV-1.MethodsUsing Illumina Massive Parallel Sequencing, we analyzed sRNA profiles from asymptomatic HTLV-1 and HTLV-2 infected individuals and healthy controls.ResultsOur results reveal significant differential expression of 331 known and 441 novel sRNAs among the groups, including miRNAs, piRNAs, and tRNAs. Notably, distinct clusters of sRNA expression patterns were identified, with specific miRNAs showing significant upregulation or downregulation in HTLV-1 and HTLV-2 infections. Gene Ontology analysis indicated significant involvement of target genes in transcription regulation and RNA-binding processes, while KEGG pathway analysis highlighted enrichment in cancer-related pathways and signaling cascades such as FoxO, Ras, and MAPK. Network analysis identified key miRNAs, such as hsa-miR-20b-5p and hsa-let-7e-5p, as central regulators with extensive interactions, suggesting their potential role in the pathogenesis and immune response of HTLV infections.DiscussionThese findings provide a foundation for future research into the molecular mechanisms of HTLV infections and the development of targeted therapies. The identified sRNAs, especially important miRNAs such as hsa-miR-20b-5p and hsa-let-7e-5p, could serve as potential biomarkers for disease progression or as therapeutic targets to modulate the immune response and disrupt viral pathogenesis. This opens up new avenues for precision medicine in HTLV-associated diseases.
Association between constipation and the urine albumin-to-creatinine ratio in adults: the NHANES 2009–2010
Authors: Yang Yuying , Rao Siyi , Zhuo Yongjie , Fang Yuan , Wan Jianxin , You Danyu 
Published: February 2025

ObjectiveThis study aimed to analyze the association between constipation and the urine albumin-to-creatinine ratio (ACR) using data from the National Health and Nutrition Examination Survey (NHANES) 2009–2010.MethodsIn this cross-sectional study, a sample of 4,282 adults aged 20 and older was selected from the NHANES 2009–2010. Constipation was defined as having fewer than three bowel movements per week. The average of the two ACR measurements was used as the outcome variable. Logistic regression models (non-adjusted and multivariate adjusted models) were used to examine the relationship between constipation and ACR. Subgroup and interaction analyses related to gender, age, smoking, alcohol consumption, body mass index (BMI), hypertension, and diabetes were also conducted to assess the stability of the association between constipation and ACR.ResultsIn this study population of 4,282 individuals, 352 individuals with an ACR of 30 mg/g or higher were considered to have albuminuria. The prevalence of constipation was higher in the albuminuria group compared to the non-albuminuric group (6.4% vs. 3.5%, p = 0.002). The unadjusted model (Model I) showed an increased risk of ACR associated with constipation (OR 1.81, 95% CI 1.13–2.91, p = 0.014). After controlling for gender, age, race/ethnicity, marital status, and education level in Model II, the association between constipation and ACR remained significant (OR 2.20, 95% CI 1.34–3.60, p = 0.002). Upon further adjustment for BMI, smoking status, alcohol consumption, diabetes, hypertension, arthritis, asthma, coronary heart disease, liver disease, cancer, blood urea nitrogen (BUN), serum creatinine (Scr), uric acid (UA) and estimated glomerular filtration rate (eGFR) in Model III, the positive association between constipation and ACR was still significant (OR 1.88, 95% CI 1.09–3.23, p = 0.023). Subgroup analyses, stratified by gender, age, smoking status, alcohol consumption, BMI, hypertension, and diabetes, showed no statistically significant interactions (p &gt; 0.05).ConclusionIn summary, this study found a positive association between constipation and urinary albumin excretion rate. The significant association between constipation and ACR highlights the need for clinicians to monitor urinary albumin levels in patients with constipation.
Dietary factors associated with breast cancer among women in Ethiopia: a systematic review and meta-analysis of case–control studies
Authors: Mekonen Habitamu , Negesse Ayenew , Endalifer Melese Linger , Molla Gebeyaw , Aneley Zelalem 
Published: February 2025

BackgroundDiet is the primary and largely modifiable factor associated with breast cancer risk. However, inconsistent findings were evidenced in many epidemiological studies and resulted in a lack of conclusiveness. Therefore, this systematic review and meta-analysis aimed to explore dietary risk factors that may predict breast cancer among Ethiopian women.Design, data source and eligibility criteriaA systematic review and meta-analysis was carried out. The articles were retrieved through electronic databases searching, including PubMed/Medline, Web of Science, Science Direct, EMBASE and Google Scholar. The Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument was applied for the critical appraisal. All case–control studies conducted in Ethiopia and reporting dietary factors of breast cancer in women were included in the final analysis.Data extractionTwo independent reviewers extracted the data using a standardized data extraction format in Excel software. Stata version 17 software was used for the data analysis. Cochran’s Q statistic with inverse variance (I2) was used to assess the presence of heterogeneity. A random effect model was used to estimate the odds ratio with a 95% confidence interval.ResultsOverall, eight eligible articles with 2,774 women were included to explore the dietary predictors of breast cancer in Ethiopia. As a result, alcohol consumption (OR: 1.26, 95% CI: 1.01, 1.57), packed food intake (OR: 6.83; 95% CI: 4.56, 10.24), saturated fat/oil intake (OR: 1.51; 95% CI: 1.13, 2.02), meat consumption (OR: 6.08, 95% CI: 3.62, 10.22), and vegetable consumption (OR: 0.75, 95% CI: 0.49, 0.89) were identified as significant predictors of breast cancer among women in Ethiopia.ConclusionThe current study revealed a significant relationship between dietary factors and breast cancer. Avoiding the consumption of alcohol, saturated fats/oils, packed foods, and meat, coupled with promotion of vegetable consumption, could substantially contribute to reduce the burden of breast cancer among women in Ethiopia. Therefore, policymakers and other concerned bodies should provide routine community-based nutrition education to raise public awareness about the contribution of women’s dietary practices on their breast cancer risk.
The evaluation of food allergy knowledge and attitude in different food sectors and the effectiveness of video-based training
Authors: Aytulu Tugce , Gundogdu Beliz Su , Yayci Elif , Ezelsoy Isil , Buyuktiryaki Betul , Veznikli Mert , Isik Sacide Rana , Sackesen Cansin 
Published: February 2025

ObjectiveFood allergies are common in the food industry. The knowledge and attitude of catering staff are crucial in preventing food allergy (FA)-related reactions. The study aimed to determine the knowledge of FA and evaluate the effectiveness of video-based allergy training for catering personnel in three sectors: restaurants, schools, and hospitals.MethodsResearch has been conducted on workers in three different catering industries: (i) restaurant chains, (ii) school kitchens, and (iii) hospital kitchens. The study involved administering surveys to the staff to measure their demographic data (11 questions), attitude (12 questions), and knowledge level (24 questions) about FA. After taking the pre-test, the participants who watched a 32-min video on FA were asked to fill out post-test questionnaires measuring their knowledge and attitudes.ResultsAt the beginning, 619 participants took the pre-test. 45.7 and 40.9% (n = 253) had a previous food Safety Certificate and food allergy training, respectively. Sixty-four percent (n = 397) received our video-based FA training. Among the participants who completed video-based training and the post-test, some knowledge and attitude items improved, but some did not, compared to the pre-test results. Knowledge levels were similar between the previously FA-trained and those untrained individuals.ConclusionOur results show that the participants’ baseline level of knowledge and attitude for FA needs improvement. After the video training, the level of improvement in some items of knowledge and attitude was significant, but it was lower than expected. It is essential for training to not only provide accurate information but also aim to correct any known misconceptions.
Prognostic factors and outcomes in pediatric acute myeloid leukemia: a comprehensive bibliometric analysis of global research trends
Authors: Rao Mingliang , Luo Wenna , Luo Caiju , Wu Baojing , Xu Tiantian , Wei Ziqian , Deng Haolan , Li Kejing , Zhou Dunhua 
Published: February 2025

BackgroundPediatric AML prognosis research has advanced significantly, yet gaps in understanding genetic and molecular interactions persist. Despite improved outcomes, relapse/refractory cases and personalized treatment integration remain critical clinical challenges.ObjectiveTo analyze the global research landscape on pediatric AML prognosis, highlight influential components and collaborations, and identify major potential research trends.MethodsPublications on pediatric AML prognosis research from 1999 to 2023 were retrieved from the Clarivate Analytics Web of Science Core Collection (WoSCC) database. Bibliometric analysis was conducted using CiteSpace and VOSviewer to identify leading countries, prominent institutions, high-impact journals, key research categories, influential authors, and emerging research topics.ResultsThe bibliometric analysis encompassed 924 publications, with St. Jude Children’s Research Hospital emerging as the most prolific institution. The United States leads globally in terms of countries, institutions, journals, and authors. Todd A. Alonzo ranks highest in publication volume, while U. Creutzig leads in citations. The top research categories were Oncology, Hematology, and Pediatrics. Key research topics included genomics, transcriptomics, epigenomics, targeted therapies, immune therapy, and integrative diagnostic approaches.ConclusionThis bibliometric analysis highlights significant advancements in pediatric AML prognosis over the past 25 years, driven by the integration of genetic markers, immunological insights, transcriptomics, and epigenomics, which have collectively transformed risk stratification and treatment strategies. Overcoming challenges, such as discovering new therapeutic targets and enhancing treatment combinations, will depend on global collaboration and advanced technologies to propel the field forward.
Correlation and predictive value of oxygenation and oxygen saturation indices in extremely preterm infants: a prospective study
Authors: Alanazi Ibrahim , Algarni Saleh S. , Alshreedah Saad , Alotaibi Naif , Sufyani Mohammed , Alanazi Sami S. , Alharthi Abeer H. , Ghazwani Abadi , Almutairi Omar M. , Alkaabi Maryam , Homedi Abdulaziz , Ali Ibrahim , Khawaji Mohammed , Alsaif Saif , Ali Kamal 
Published: February 2025

AimsThis study aims to evaluate the association between the Oxygenation Index (OI) and the Oxygen Saturation Index (OSI) in extremely preterm infants. In addition, the study seeks to determine the predictive value of these indices for mortality in the first 7 days and Bronchopulmonary Dysplasia (BPD) at 36 weeks postmenstrual age (PMA).MethodsThis is a prospective observational study conducted at King Abdulaziz Medical City, Riyadh between October 2023 and May 2024, involving extremely preterm infants with clinical and ventilator data collected during the first 7 days of life. The predictive capabilities of OI and OSI for mortality within the first 7 days and BPD at 36 wks. PMA were assessed using Area Under the Curve (AUC) analysis, while associations between indices were explored through Spearman's correlation coefficient.ResultsThe study included 85 infants with a mean birth weight of 856 grams (SD = 243) and a mean gestational age of 26 weeks (SD = 1.8). There was a strong positive correlation between OI and OSI overall (r = 0.848, p &lt; 0.001, n = 85), with similar findings in both surviving (r = 0.831, p &lt; 0.001, n = 71) and non-surviving groups (r = 0.896, p &lt; 0.001, n = 14). Bland-Altman plots showed a mean difference of 3 between OI and OSI for all infants, with limits ranging from −4 to +8. Tighter agreement was observed in survivors with a mean difference of 2 and limit from −4 to +7, while non-survivors showed a larger mean difference of 4.5 and wider limits of agreement from −8 to +17. Receiver Operating Characteristic (ROC) analysis for survival prediction focused on indices measured within the first 24 h, demonstrating high predictive accuracy. Additionally, the mean daily values for OI and OSI between Day 4 and Day 7 were found to be predictive of BPD at 36 wk. PMA.ConclusionsMeasurements of OI and OSI within the first 24 h effectively predict mortality in extremely preterm infants. Additionally, daily mean values of OI and OSI from day 4 to day 7 were predictive of BPD at 36 weeks PMA. Further research is needed to refine these diagnostic thresholds to enhance neonatal care outcomes.
Beyond radicalization: the 3N model and its application to criminal attitudes in high-risk contexts
Authors: Bélanger Jocelyn J. , Wolfowicz Michael , Mohammad Hayat , Lobato Roberto M. , Blaya Burgo Michelle , Rico-Bustamante Laura , Martín-Criado José M. , Moyano Manuel 
Published: February 2025

IntroductionThis research integrates criminological and psychological literature by applying the 3N model of radicalization to predict criminal attitudes. Specifically, we conceptualize “need” as the search for meaning, “networks” as deviant associations, and “narrative” as criminal attitudes. We examine the roles of these factors across diverse cultural contexts and investigate the effectiveness of prosocial models in redirecting the search for meaning away from criminal attitudes.MethodsThree studies were conducted to examine the relationships between the search for meaning, deviant associations, and criminal attitudes. Study 1A sampled former inmates in Pakistan (N = 243), while Study 1B (N = 402) and Study 2 (N = 330) focused on at-risk youth in southern Spain. Study 2 further tested a field intervention using positive role models to mitigate the search for meaning and criminal attitudes.ResultsFindings from Studies 1A and 1B indicate a significant indirect effect of the search for meaning on criminal attitudes, mediated through deviant associations. Additionally, Study 2 demonstrates that exposure to prosocial role models reduces both the search for meaning and criminal attitudes, supporting the effectiveness of intervention strategies.DiscussionThese findings highlight the utility of the 3N model in understanding criminal attitudes within diverse high-risk contexts. By bridging psychological and criminological perspectives, this research offers a framework for prevention and intervention strategies targeting individuals vulnerable to criminal influences.
Scoping review: outpatient psychotherapeutic care for children and adolescents in Germany—status quo and challenges in assessment
Authors: Rodney-Wolf Kristin , Schmitz Julian 
Published: February 2025

BackgroundIn the context of multiple global crises, including the COVID-19 pandemic, climate change, and global conflicts, children and adolescents worldwide are experiencing heightened psychological stress. As the foundation for lifelong mental health is established during childhood and adolescence, early prevention and treatment of mental health problems, such as through psychotherapy, are crucial. In Germany, current outpatient psychotherapeutic care capacities appear inadequate, while systematic evaluations of the care situation are lacking. This study investigates the state of statutory health insurance-funded outpatient psychotherapeutic care for children and adolescents in Germany and evaluates various methodological approaches for its assessment.MethodsWe conducted a scoping review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. Publications from January 2018 to December 2023 were sourced from PubPsych, PubMed, APA PsycInfo, Google Scholar, and ProQuest. Included studies report quantitative primary data on the mental health of community samples of children and adolescents in Germany or their outpatient psychotherapeutic care.ResultsWe included 41 publications comprising epidemiological studies, administrative data, and psychotherapist and patient reports. A lack of systematic and standardised research approaches resulted in significant variance in data. Nonetheless, qualitative analysis revealed that approximately one four children and adolescents in Germany is affected by mental health problems, while one in six to seven children and adolescents requires psychotherapeutic treatment. Yet, only up to one in 50 receives guideline-based psychotherapy. Most requests for initial psychotherapeutic consultations are unmet, with waiting times for guideline-based psychotherapy exceeding 6 months for at least half of the patients.ConclusionOverall, our findings suggest that outpatient psychotherapeutic care for children and adolescents in Germany is still insufficient. They advocate for a systematic, multimodal, and longitudinal assessment of statutory health insurance-funded outpatient psychotherapeutic care, along with an expansion of treatment capacities to enhance access for children and adolescents in Germany.
The Italian version of the unified theory of acceptance and use of technology questionnaire: a pilot validation study
Authors: D’Iorio Alfonsina , Garramone Federica , Rossi Silvia , Baiano Chiara , Santangelo Gabriella 
Published: February 2025

BackgroundThe Unified Theory of Acceptance and Use of Technology is a self-rated questionnaire to assess twelve constructs related to the level of acceptance of a robot, consisting of 41 items rated on a 5-point Likert scale. The aim of the study was to conduct a preliminary evaluation of the psychometric properties of the Italian version of the UTAUT (I-UTAUT) in a sample of Italian healthy subjects (HCs).Materials and methods30 HCs underwent the I-UTAUT to assess its comprehensibility. Reliability and divergent validity of the I-UTAUT were evaluated in a sample of 121 HCs, who also underwent the Montreal Cognitive Assessment (MoCA).ResultsThe final I-UTAUT version was easily comprehensible. There were no missing data, no floor and ceiling effects. Contrarily to the original version, the Principal Components Analysis suggested a seven-component structure; Cronbach’s alpha was 0.94. The I-UTAUT score did not correlate with MoCA.ConclusionThe I-UTAUT represented a reliable and valid questionnaire to identify the level of acceptance of robotics technology in Italian healthy sample.
Criação de núcleo de aeronave remotamente pilotada (ARP) em cada comando intermediário da Polícia Militar Paraná (PMPR)
Authors: Iark Andrey Müller 
Published: February 2025

O objetivo deste estudo foi analisar o regramento e normatização para operações das aeronaves remotamente pilotadas utilizadas pelas Polícias Militares, levando em conta a atual legislação, normativas e resoluções da ANAC, DECEA, ANATEL, para sugerir a criação de núcleos de drones em cada comando regional da PMPR. O método empregado neste estudo foi o dedutivo, efetivado por meio de revisão da literatura originada pela análise de material selecionado em mecanismos de busca como Scielo, Google Acadêmico, banco de teses e a doutrina e legislação vigente. Os resultados mostraram que tecnologia de drones tem reflexo direto em múltiplos aspectos que interferem desde a capacidade de monitoração de grandes áreas com maior precisão, incluindo a diminuição dos custos operacionais e minimização dos riscos pelos quais os policiais militares passam. Por isso, é indispensável estabelecer diretrizes com clareza e regulamentações que asseguram a utilização destes equipamentos, respeitando a conformidade com as legislações e diretrizes vigentes. Conclui-se que esta ferramenta tecnológica é de grande utilidade a nível operacional, e também bastante pertinente quando do assessoramento aos níveis táticos e estratégicos, por isso, a criação dos núcleos de drone torna-se uma ferramenta muito relevante neste processo.
Flexible self-written optical waveguide and optical self-coupling with polymeric cladding
Authors: Kakurai Hayato , Terasawa Hidetaka , Kondo Keisuke , Sugihara Okihiro 
Published: February 2025

Abstract
The future high-speed data transmission in autonomous driving systems will require low-cost optical connection technology that can mitigate alignment accuracy between fibers and withstand vibration. We proposed and demonstrated an optical self-coupling using near-infrared flexible light-induced self-written (LISW) optical waveguides with polymeric cladding between two graded-index multimode optical fibers having a core diameter of 50 μm. An ultraviolet curable cladding resin mixture was selected by considering Young’s modulus and refractive index values. The insertion loss and tolerance for misalignment of the optical fibers were improved by covering the LISW optical waveguide core with an appropriate cladding material.