bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prefrontal Cortex Transcranial Direct Current Stimulation Treatment in
Alcohol Dependence Syndrome (PreCoTTA): Study Protocol for a Double-
blind Randomized Sham-controlled Trial
Authors: Deshmukh Anagha S. , Praharaj Samir Kumar , Rai Shweta , Kamath Asha , Upadhya Dinesh 
Published: August 2021

Background:
Alcohol dependence is a significant public health problem, contributing to
the global health burden. Due to its immense socio-economic burden, various psychosocial, psychological,
and pharmacological approaches have attempted to alter the behaviour of the patient misusing
or abusing alcohol, but their efficacy is modest at best. Therefore, there is a search for newer
treatment approaches, including non-invasive brain stimulation in the management of alcohol dependence.
We plan to study the efficacy of Prefrontal Cortex Transcranial direct current stimulation
Treatment in Alcohol dependence syndrome (PreCoTTA).

Methods:
Two hundred twenty-five male patients with alcohol dependence syndrome will be randomized
into the three study arms (2 active, left dorsolateral prefrontal cortex and left orbitofrontal
cortex, and 1 sham) to receive a total of 14 tDCS sessions (10 continuous and 4 booster sessions).
Data will be collected from these sessions at five different time points on clinical, neuropsychological
and biochemical parameters. In addition, 225 healthy age and education matched controls will
be administered the neuropsychological test battery at baseline for comparison with the patient
group.

Discussion:
The proposed study aims to explore the use of non-invasive brain stimulation; tDCS
as a treatment alternative. We also aim to overcome the methodological gaps of limited sample
sizes, fewer tDCS intervention sessions, lack of long-term follow-ups to measure the sustainability
of gains, and lack of comprehensive measures to track changes in functioning and abstinence after
tDCS intervention. The main outcomes include clinical (reduction in cue-induced craving, time to
first drink, and QFI); neuropsychological (risk-taking, impulsivity, and other neuropsychological
domains), and biochemical markers (BDNF, leptin and adiponectin). The findings of the study will
have translational value as they may help to improve the clinician’s ability to effectively manage
craving in patients with alcohol dependence syndrome. Furthermore, we will have a better understanding
of the neuropsychological and biochemical effects of non-invasive brain stimulation techniques
which are of interest in the comprehensive treatment of addiction disorders.

Trial registration:
The study has been registered with the Clinical Trials Registry-India (CTRI/
2020/09/027582) on September 03rd 2020.
Potential Therapeutic Benefits of Sodium-Glucose Cotransporter 2 Inhibitors
in the Context of Ischemic Heart Failure: A State-of-the-Art Review
Authors: Gitto Mauro , Vrachatis Dimitrios A. , Condorelli Gianluigi , Papathanasiou Konstantinos , Reimers Bernhard , Deftereos Spyridon , Stefanini Giulio G 
Published: August 2021

:
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a class of anti-diabetic agents
that block the reabsorption of glucose in the proximal convoluted tubule of the nephron, thereby
contributing to glycosuria and lowering blood glucose levels. SGLT2 inhibitors have been associated
with improved cardiovascular outcomes in patients with diabetes, including a reduced risk of
cardiovascular death and hospitalizations for heart failure. Recently, DAPA-HF and EMPEROR
REDUCED trials showed the beneficial cardiovascular effect of SGLT2 inhibitors in patients with
heart failure with consistently reduced ejection fraction (HFrEF) regardless of the presence of diabetes.
Moreover, some exploratory studies suggested that these drugs improve Left Ventricular
(LV) systolic function and oppose LV adverse remodeling in patients with HFrEF. However, the
exact mechanisms that mediated for this benefit are not fully understood. Beyond glycemic control,
enhanced natriuresis, increased erythropoiesis, improved endothelial function and changes in myocardial
metabolism may all play an active role in SGLT2 inhibitors’ cardiovascular benefits. A
deep understanding of the pathophysiological interplay is key to define which HF phenotype could
benefit more from SGLT2 inhibitors. Current evidence on the comparison of different HF etiologies
is limited to posthoc subgroup analysis of DAPA-HF and EMPEROR-REDUCED, which
showed similar outcomes in patients with or without ischemic HF. On the other hand, in earlier
studies of patients suffering from diabetes, rates of classic ischemic endpoints, such as myocardial
infarction, stroke or coronary revascularization, did not differ between patients treated with SGLT2
inhibitors or placebo. The aim of this review is to discuss whether SGLT2 inhibitors may improve
prognosis in patients with ischemic HF, not only in terms of reducing re-hospitalizations and improving
LV function but also by limiting coronary artery disease progression and ischemic burden.
Drosophila: A Model to Study the Pathogenesis of Parkinson’s Disease
Authors: Rahul  , Siddique Yasir Hasan 
Published: August 2021

:Human Central Nervous System (CNS) is the complex part of the human body, which regulates multiple cellular and molecular events taking place simultaneously. Parkinsons Disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease (AD). The pathological hallmarks of PD are loss of dopaminergic neurons in the substantianigra (SN) pars compacta (SNpc) and accumulation of misfolded α-synuclein, in intra-cytoplasmic inclusions called Lewy bodies (LBs). So far, there is no cure for PD, due to the complexities of molecular mechanisms and events taking place during the pathogenesis of PD. Drosophila melanogaster is an appropriate model organism to unravel the pathogenicity not only behind PD but also other NDs. In this context as numerous biological functions are preserved between Drosophila and humans. Apart from sharing 75% of human disease-causing genes homolog in Drosophila, behavioral responses like memory-based tests, negative geotaxis, courtship and mating are also well studied. The genetic, as well as environmental factors, can be studied in Drosophila to understand the geneenvironment interactions behind the disease condition. Through genetic manipulation, mutant flies can be generated harboring human orthologs, which can prove to be an excellent model to understand the effect of the mutant protein on the pathogenicity of NDs.
Are Lysosomes Potential Therapeutic Targets for Parkinson’s Disease?
Authors: Petese Alessandro , Cesaroni Valentina , Cerri Silvia , Blandini Fabio 
Published: August 2021

Background:
Parkinson´s disease (PD) is the second most common neurodegenerative
disorder, affecting ~2-3% of the population over 65 years old. In addition to progressive degeneration
of nigrostriatal neurons, the histopathological feature of PD is the accumulation of misfolded
α-synuclein protein in abnormal cytoplasmatic inclusions, known as Lewy Bodies (LBs). Recently,
genome-wide association studies (GWAS) have indicated a clear association of variants within several
lysosomal genes with risk for PD. Newly evolving data have been shedding light on the relationship
between lysosomal dysfunction and alpha-synuclein aggregation. Defects in lysosomal enzymes
could lead to the insufficient clearance of neurotoxic protein materials, possibly leading to
selective degeneration of dopaminergic neurons. Specific modulation of lysosomal pathways and
their components could be considered a novel opportunity for therapeutic intervention for PD.

Aim:
The purpose of this review is to illustrate lysosomal biology and describe the role of lysosomal
dysfunction in PD pathogenesis. Finally, the most promising novel therapeutic approaches designed
to modulate lysosomal activity, as a potential disease-modifying treatment for PD will be
highlighted.
Effectiveness of an Internet-Based Machine-Guided Stress Management Program Based on Cognitive Behavioral Therapy for Improving Depression Among Workers: Protocol for a Randomized Controlled Trial
Authors: Kawakami Norito , Imamura Kotaro , Watanabe Kazuhiro , Sekiya Yuki , Sasaki Natsu , Sato Nana ,   SMART-CBT Project Team
Published: August 2021

Background
The effect of an unguided internet-based cognitive behavioral therapy (iCBT) stress management program on depression may be enhanced by applying artificial intelligence (AI) technologies to guide participants adopting the program.

Objective
The aim of this study is to describe a research protocol to investigate the effect of a newly developed iCBT stress management program adopting AI technologies on improving depression among healthy workers during the COVID-19 pandemic.

Methods
This study is a two-arm, parallel, randomized controlled trial. Participants (N=1400) will be recruited, and those who meet the inclusion criteria will be randomly allocated to the intervention or control (treatment as usual) group. A 6-week, six-module, internet-based stress management program, SMART-CBT, has been developed that includes machine-guided exercises to help participants acquire CBT skills, and it applies machine learning and deep learning technologies. The intervention group will participate in the program for 10 weeks. The primary outcome, depression, will be measured using the Beck Depression Inventory II at baseline and 3- and 6-month follow-ups. A mixed model repeated measures analysis will be used to test the intervention effect (group × time interactions) in the total sample (universal prevention) on an intention-to-treat basis.

Results
The study was at the stage of recruitment of participants at the time of submission. The data analysis related to the primary outcome will start in January 2022, and the results might be published in 2022 or 2023.

Conclusions
This is the first study to investigate the effectiveness of a fully automated machine-guided iCBT program for improving subthreshold depression among workers using a randomized controlled trial design. The study will explore the potential of a machine-guided stress management program that can be disseminated online to a large number of workers with minimal cost in the post–COVID-19 era.

Trial Registration
UMIN Clinical Trials Registry（UMIN-CTR) UMIN000043897; https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000050125

International Registered Report Identifier (IRRID)
PRR1-10.2196/30305
Gamero Casado, Eduardo (dir.), La potestad administrativa. Concepto y alcance práctico de un criterio clave para la aplicación del Derecho administrativo. Valencia, Tirant lo blanc, 2021, 917 pp.
Authors: Gómez Rodríguez Eugenio Alejandro 
Published: August 2021

En este libro se analiza La potestad administrativa, la cual ha sido protagonista en diversas obras de Derecho Administrativo con carácter general, pero nunca se le había dedicado íntegramente una monografía en la manera en que lo hacen aquí estos autores .La monografía se estructura en tres partes. La primera es la Teoría general de la potestad administrativa. La segunda se refiere al ejercicio de potestades administrativas por poderes públicos distintos de la Administración. La última destinada al Análisis sectorial de las potestades administrativas. En total conforman estas tres partes quince capítulos, que se distribuyen en siete, dos y seis, respectivamente; todo ello precedido por una magnífica introducción a cargo del director de la obra.
Cómo construir un instrumento para evaluar la lectura crítica de investigación de informes médicos
Authors: Cobos-Aguilar Héctor 
Published: August 2021

Introducción: La investigación y la lectura crítica de informes médicos publicados (LCIM), cuando se ejercita, es el fundamento de una actividad clínica depurada. Las publicaciones médicas son exponenciales y una LCIM mejora la selección de artículos con metodología robusta. A pesar de su importancia, los currículos universitarios no enfatizan su aprendizaje. Para medir el grado de LCIM los reportes que utilizan instrumentos adolecen, en su mayoría, de validez y consistencia, lo que dificulta la toma de decisiones educativas en esta área.
Objetivo: Compartir el proceso de construcción de un instrumento de evaluación de LCIM inmerso en una educación participativa.
Métodos: Se presentan los pasos para construir un instrumento para evaluar la LCIM. Se define la lectura crítica como la confrontación del lector con el texto que comprende la interpretación (lo implícito del texto, el reconocimiento de los componentes metodológicos), el juicio (ponderación de los componentes del artículo consultado) y las propuestas (idear componentes que superen a los presentados por el autor) desde la experiencia del lector y en su contexto. Se enuncian los diferentes diseños y apartados que se considera debe contener un instrumento de esta naturaleza. Se propone cómo elaborar un resumen de un artículo, así como los tallos de los que se derivan los reactivos que exploran los tres indicadores citados antes, la técnica Delphi y sugerencias para determinar la consistencia.
Resultados: Se elaboró un resumen de casos y controles, como ejemplo, así como un listado de los tres indicadores, una tabla que los identifica y la secuencia de pasos indispensables en un reporte como este.
Conclusiones: Los instrumentos para medir la LCIM deben seguir un proceso riguroso en su elaboración, lo que permitirá tomar mejores decisiones educativas.
The Study of Digital Adoption and Usage Trends in Kolkata Area
Authors: Shit Sourav 
Published: August 2021

This study is based on a research which was done in order to know the awareness and usage of the people toward internet. Mainly this study was focused on the urban people who are lived in the place like Kolkata and much more educated then the rural people. Under this I tried to find out that out of the total sample how many are aware about the internet, how many use internet regularly, how many occasionally (Before 1month), internet owner and non-users. For this study I follow certain process of market research. I had the sample of 65 respondents. For that we conducted this study and collected data from the urban households about their perception and usage of internet it is concern that it aims towards to get direct response form the respondents and to disseminate awareness among the people aware internet. Except this it also has various aims like preference towards internet, purchasing capacity of respondents, fulfill the respondents expectation etc. There are some important factors to carry the research in a careful manner. The key factors are 	Active Internet User 	Claim Internet User 	Internet Owner 	Non-User of Internet 	Perception and Preference of People Towards Internet
A importância da Odontologia na assistência a indivíduos com defeitos congênitos
Authors: Santa Maria Fernanda Diffini , De Oliveira Bibiana Mello , Schuler-Faccini Lavinia 
Published: August 2021

Introduction: Birth defects are structural or functional changes that occur during intrauterine life. The dentist must recognize the craniofacial defects, complement the phenotypic characterization and manage them within a multidisciplinary team. The present review aims to assist the dentist to diagnose these findings and present syndromic conditions typically associated with craniofacial malformations
Literature Review: Craniofacial manifestations of birth defects are conditions that must be recognized by dentists, as they are frequently present in their daily practices, and this professional may be the first to identify such findings. The main syndromic clinical pictures typically associated with micrognathia, oral clefts and skeletal dysplasias with craniofacial manifestation are presented, pointing out their clinical and genetic features. Discussion: The dentist must perform a detailed anamnesis including family history, as well as should recognize both clinical and radiographically the dysmorphisms, observing the patient systemically. Conclusion: Dentistry professionals should receive theoretical-practical training for the diagnosis, treatment and surveillance of individuals with congenital defects, either in individual assessment or as part of a multiprofessional team.
Left ventricular summit -- concept, anatomical description and clinical significance
Authors: Kuniewicz Marcin , Baszko Artur , Holda Mateusz , Ali Dyjhana , Karkowski Grzegorz , Walocha Jerzy 
Published: August 2021

The left ventricular summit (LVS) is a triangular area located at the
most superior portion of the left epicardial ventricular region,
surrounded by the two branches of the left coronary artery: the left
anterior interventricular artery and the left circumflex artery. The
triangle is bounded by the apex, septal and mitral margins and base.
This review aims to provide a systematic and comprehensive anatomical
description and proper terminology in the LVS region that may facilitate
exchanging information among anatomists and electrophysiologists,
increasing knowledge of this cardiac region. We postulate that the most
dominant septal perforator (not the first septal perforator) should
characterize the LVS definition. Abundant epicardial adipose tissue
overlying the LVS myocardium may affect arrhythmogenic processes and
electrophysiological procedures within the LVS region. The LVS is
divided into two clinically significant regions: accessible and
inaccessible areas. Rich arterial and venous coronary vasculature and a
relatively dense network of cardiac autonomic nerve fibers are present
within the LVS boundaries. Although the approach to the LVS may be
challenging, it can be executed indirectly using the surrounding
structures. Delivery of the proper radiofrequency energy to the
arrhythmia source, avoiding coronary artery damage at the same time, may
be a challenge. Therefore, coronary angiography or cardiac computed
tomography imaging is strongly recommended before any procedure within
the LVS region. Further research on LVS morphology and physiology should
increase the safety and effectiveness of invasive electrophysiological
procedures performed within this region of the human heart.
Published in Diagnostics:

https://doi.org/10.3390/diagnostics11081423
MONITORING OF HAZARDOUS NATURAL AND TECHNOGENIC PROCESSESS ON THE TERRITORY OF RNO-ALANIA
Authors: Дзеранов Б.В. , Мельков Д.А. , Заалишвили В.Б. , Невский Л.Н. , Невская Н.И. , Кануков А.С. , Шепелев В.Д. 
Published: August 2021

В связи с активизацией опасных природных процессов на Кавказе и, в частности, сходом ледника Колка 20 сентября 2002 года существующая республиканская сейсмическая сеть наблюдений Центра в конце 2003 года была преобразована в сеть комплексных наблюдений Кармадонский параметрический полигон . Целью функционирования сети является исследование природно-техногенных опасных геологических процессов в горных районах
In connection with activization of hazardous and technogenic processes in Caucasus and, in particular, fall of glacier Kolka (happened on 20 September 2002) existing republican seismic network was reconstructed in network of complex observations Karmadon paramentric range. The goal of network operation is investigation of nature-technogenic hazardous geological processes in mountain regions
ON SOME PHYSICAL GROUNDS OF ALLEGED AND ACTUAL MECHANISMS OF GLACIAL MUDFLOWS CATASTROPHES: KOLKA, 2002
Authors: Бергер М.Г. , Чотчаев Х.О. 
Published: August 2021

В статье высказаны замечания по основным положениям гипотезы В. Л. Познанина и С. Г. Геворкяна о механизмах подготовки и проявления катастрофы 2002 г. на леднике Колка. Показаны физическая необоснованность и ошибочность этой гипотезы и ее несоответствие реальным фактам.
The article comments on the V. L. Poznanin and S. G. Gevorgyan framework hypothesis on arrangement mechanisms of the Kolka glaciercatastrophe 2002 preparation. The hypothesis physical invalidity is shown, and real facts mismatch
THE EXPERIENCE AND THE RESULTS OF ENGINEERSEISMOMETRIC MONITORING OF ARMENIAN HYDRAULIC STRUCTURES
Authors: Оганесян С.М. , Карапетян С.С. , Геодакян Э.Г. , Карапетян Дж.К. , Аукажиева Ж.М. , Гаспарян А.С. , Мкртчян Г.А. 
Published: August 2021

В работе приводятся результаты мониторинга системы инженерно-сейсмологического наблюдения, разработанных ИГИС НАН РА, для грунтовых плотин.
The results of the monitoring system of the engineering seismological observation of NAS RA IGIS for ground dams
ONCOLOGY DISEASE RATE OF VLADIKAVKAZ CITY POPULATION AND ITS INTERRELATION WITH VARIOUS FACTORS
Authors: Заалишвили В.Б. , Бериев О.Г. , Бурдзиева О.Г. , Закс Т.В. , Кануков А.С. 
Published: August 2021

Изучено развитие новообразований у жителей г. Владикавказ и проведен анализ зависимости роста онкозаболеваемости от удаленности от промышленных объектов. Разработана база данных с целью обработки полученных данных
The neoplasm development of the urban residents on the example of Vladikavkaz city was investigated and the cancer rates growth with the range from industrial sites is analyzed. A database has been developed to process the obtained data
NEW IDEAS ABOUT DEEP STRUCTURE OF OSSETIAN SECTOR OF GREATER CAUCASUS
Authors: Рогожин Е.А. , Горбатиков А.В. , Заалишвили В.Б. , Степанова М.Ю. , Харазова Ю.В. , Андреева Н.В. , Мельков Д.А. , Дзеранов Б.В. , Дзебоев Б.А. , Габараев А.Ф. 
Published: August 2021

Составлен профиль МСЗ в Осетинском секторе Большого Кавказа. Получена информация о глубинном строении складчатого сооружения. По результатам геолого-геофизического изучения сделаны за- ключения о глубинном строении Большого Кавказа
The MSZ profile of the ossetic sector of the large Caucasus is composed. Information about the deep structure of plicated construction is obtained. The conclusions about the deep structure of the large Caucasus are made according to the results of geological-geophysical study
MECHANISM OF SESMIC PROCESSES INFLUENCE AT ORE MINING REGION
Authors: Голик В.И. , Бурдзиева О.Г. , Невский Л.Н. 
Published: August 2021

Уточнено понятие о геологической среде горнодобывающего региона. Дана характеристика актив- ности неотектонических и других эндогенных геологических процессов, объекта добычи и переработки полиметаллических руд. Показано, что в условиях высокой сейсмической опасности экологические про- блемы территории значительно усугубляются. Делается вывод о необходимости учета возможных по- следствий влияния сейсмических воздействий при оценке интегральной природно-техногенной опасности горнодобывающего производства
The concept of the mining region geological medium is refined. The activity characteristic of the neotectonic and other endogenous geological processes of the output objects and processing of polymetallic ores. It is shown that under the high seismic danger conditions the ecological problems of territory with the high ecosystem vulnerability are considerably aggravated. This specifies the high seismic risk of North Ossetia. Conclusion about the need for the calculation of the possible consequences of the seismic actions influence during the estimation of the integral natural technogenic danger of the mining production is done
COMPARATIVE ESTIMATES OF GROUND ACCELARATION DAMPING EFFECT
Authors: Григорян В.Г. 
Published: August 2021

На основе сравнительного анализа и сопоставлений существующих моделей затухания эффекта землетрясения аргументирована и обоснована целесообразность использования для практических задач более простых (универсальных) моделей Amax F (M,R). С использованием большого объема экспериментальных данных о сильных и разрушительных землетрясениях, происшедших в регионе, определены коэффициенты заданной универсальной модели, которую рекомендуется использовать как наиболее приемлемую для территории Армении
On the basis of comparative analysis and comparison of existing models of earthquakes damping effect, it was argued and found reasonable for practical tasks the application of simpler (universal) models A max F (M,R). With the use of wide range of experimental data on strong and distractive earthquakes occurred in the region, coefficients of given universal model are determined, which is recommended as the most reliable on the territory of Armenia