bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluid deafness: earwax and hardness of hearing in early modern Europe
Authors: Verwaal Ruben E. 
Published: November 2021

AbstractThis article discusses hearing disability in early modern Europe, focusing on medical ideas to demonstrate a profound shift in thinking about deafness over the course of the eighteenth century. Scholars have previously described changes in the social status of the deaf in the eighteenth century, pointing at clerics’ sympathy for the deaf and philosophers’ fascination with gestures as the origin of language, but there is remarkably little scholarship on the growing interest in deafness and hardness of hearing by physicians. From the seventeenth century onwards, however, medical men investigated earwax and mucus in the Eustachian Tube and developed theories about the propagation of sound waves via fluid airs and nervous juices in relation to hearing and deafness. This article argues that this focus on fluids brought about a new medical understanding of auditory perception, which viewed hearing and deafness not as dichotomous but as states along a continuous spectrum. As such, this article offers a new perspective on the study and treatment of hearing difficulties in early modern Europe, arguing that there was no solid dividing line between deafness and hearing; if anything, it was permeable and unstable.
Making Sense of Human Rights Diplomacy: Evidence from a US Campaign to Free Political Prisoners
Authors: Myrick Rachel , Weinstein Jeremy M. 
Published: November 2021

AbstractScholarship on human rights diplomacy (HRD)—efforts by government officials to engage publicly and privately with their foreign counterparts—often focuses on actions taken to “name and shame” target countries because private diplomatic activities are unobservable. To understand how HRD works in practice, we explore a campaign coordinated by the US government to free twenty female political prisoners. We compare release rates of the featured women to two comparable groups: a longer list of women considered by the State Department for the campaign; and other women imprisoned simultaneously in countries targeted by the campaign. Both approaches suggest that the campaign was highly effective. We consider two possible mechanisms through which expressive public HRD works: by imposing reputational costs and by mobilizing foreign actors. However, in-depth interviews with US officials and an analysis of media coverage find little evidence of these mechanisms. Instead, we argue that public pressure resolved deadlock within the foreign policy bureaucracy, enabling private diplomacy and specific inducements to secure the release of political prisoners. Entrepreneurial bureaucrats leveraged the spotlight on human rights abuses to overcome competing equities that prevent government-led coercive diplomacy on these issues. Our research highlights the importance of understanding the intersection of public and private diplomacy before drawing inferences about the effectiveness of HRD.
Rock Failure Envelope and Behavior Using the Confined Brazilian Test
Authors: Li Yawei , Ghassemi Ahmad 
Published: November 2021

AbstractComplete rock strength envelopes spanning both the tensile and compressive stress domains are essential to engineering design in Rock. However, the exact shape of the envelope in the tensile zone is not known. The major impediment to establishing the true profile of the envelope is the inherent difficulties in conducting tension tests under confinement. In this study, we use the confined Brazilian test to investigate the impact of confining pressure on tensile strength, the failure mechanism, and the brittle‐ductile transition. By applying a constant confining pressure, a state of triaxial stress is created in the disc such that the disc center is under three nonzero and unequal principal stress components. By increasing the confining pressure, the least principal stress changes from tensile to compressive so that rock failure can be observed over a wide range of stress conditions. Four lithologies have been tested in this study, including limestone and three sandstones. Experimental results suggest that the complete strength envelope resembles an offset parabola opening to the right with its vertex above the horizontal axis in the domain. The tensile strength shows a pronounced increase under confinement. For all lithologies tested, tensile fracturing disappears as the confining pressure increases, with the stress‐displacement curves exhibiting typical brittle‐ductile transitions and a change in failure mode from extension to shear. Observation of the progressive increase in the fracture angle with confining pressure also provides laboratory evidence for the continuous transition of failure from extension to shear.
Response of Southern Hemisphere Western Boundary Current Regions to Future Zonally Symmetric and Asymmetric Atmospheric Changes
Authors: Goyal Rishav , England Matthew H. , Jucker Martin , Sen Gupta Alex 
Published: November 2021

AbstractSubtropical western boundary currents (WBCs) are often associated with hotspots of global warming, with certain WBC extension regions warming 3–4 times faster than the global mean. In the Southern Hemisphere, strong warming over the WBC extensions has been observed over the last few decades, with enhanced warming projected into the future. This amplified warming has primarily been linked to poleward intensification of the mid‐latitude westerly winds in the Southern Hemisphere. Changes in these winds are often thought of as being zonally symmetric; however, recent studies show that they contain strong zonal asymmetries in certain ocean basins. The importance of these zonal asymmetries for the Southern Ocean has not yet been investigated. In this study, we use an ocean‐sea‐ice model forced by prescribed atmospheric fields to quantify the contribution of projected zonally asymmetric atmospheric changes in generating future ocean warming and circulation changes in the subtropical WBC regions. We find that the zonally asymmetric component of atmospheric forcing, characterized by a pattern that is consistent across CMIP6 models, can explain more than 30% (>2°C) of the sea surface temperature (SST) warming found in the Tasman Sea and southern Australia region and a sizable fraction of warming in the Agulhas Current region. These changes in SST in both the Indian and Pacific basins are found to be primarily driven by increases in the advection of warm tropical water to the mid‐latitudes due to changes in the large‐scale subtropical ocean gyres, which in turn can largely be explained by changes in the mid‐latitude surface wind stress patterns.
Structure and Large‐Scale Organization of Extreme Cold Wave Events Over the Chinese Mainland During the Boreal Cold Season
Authors: Zhang L. , Xie Z. , Deng Y. , Huang W. 
Published: November 2021

AbstractRecent changes in the Earth's climate have led to renewed interest in extreme cold wave (ECW) events. This study identifies the ECW patterns over the Chinese mainland, their corresponding large‐scale meteorological patterns (LMPs) and their favorable planetary wave patterns over 1961–2015. A self‐organizing map classifies ECWs into northeast, nationwide, northwest–south and Qinghai–Tibetan Plateau clusters. The cold anomalies are primarily contributed by the anomalous wind advecting climatological mean temperature for the leading three clusters, but diabaitic heating for the Qinghai–Tibetan Plateau cluster. The associated LMPs are primarily characterized by a dipole with a positive height anomaly over Siberia and a negative height anomaly extending from Japan to the Iranian Plateau, which displaces southwestward among the four ECW clusters. The LMPs induce anomalous northerly flows extending from the upper troposphere to the near‐surface, which deepen the negative height anomaly southwestward from the East Asian trough and accumulate cold air masses over the key regions within the dipole that are phase‐locked with the LMPs (i.e., baroclinic growth). Such baroclinic growth of the LMP is larger during periods of a planetary wave (wavenumbers 1–5) resembling the Northern Annular Mode (NAM). Meanwhile, the negative (positive) phase of the NAM provides more direct contribution to the LMP of the northeast and nationwide (Qinghai‐Tibetan Plateau) ECW clusters and thus are likely to favor the occurrence of ECWs. The negative phase of NAM‐like planetary waves exhibit a positive trend after the transition year of 1987, and could potentially increase the occurrence frequency of nationwide ECWs.
Controlling the three dimensional propagation of spin waves in continuous ferromagnetic films with an increasing out of plane undulation
Authors: Montoncello Federico , Gubbiotti Gianluca 
Published: November 2021

AbstractThe role of three-dimensionality in a ferromagnetic medium in ruling the propagation properties of spin-waves (SW) has been one of the main focuses of the research activity in recent years. In this context, we investigate the evolution of the SW dispersion (frequency vs wave vector) induced by a progressive vertical undulation of a ferromagnetic film. The geometric undulation is taken along a single direction and is periodic with constant period, while the amplitude (differential maximum height with respect to the film thickness) is gradually increased from 0 to 60 nm. We study the characteristic modification of the internal effective field and link it to the resulting SW dispersions and spatial profile. These systems display at once features both of a planar film and a discretized medium, and the dispersion curves change not only when SWs propagate along the undulation direction, but also perpendicular to it. We discuss the geometric and magnetic conditions for having either the invariance of the SW group velocity with respect to even major changes in the undulation, or a large group velocity for some edge modes. We address a potential dual-band activity, namely the simultaneous propagation of two independent SW-signals, with separated frequency bands and disjoint oscillation regions.
Genetic variation in NDFIP1 modifies the metabolic patterns in immune cells of multiple sclerosis patients
Authors: López-Cotarelo Pilar , González-Jiménez Adela , Agudo-Jiménez Teresa , Abarca-Zabalía Judith , Aladro Yolanda , Pilo Belén , Comabella Manuel , Espino-Paisán Laura , Urcelay Elena 
Published: November 2021

AbstractOne of the 233 polymorphisms associated with multiple sclerosis (MS) susceptibility lies within the NDFIP1 gene, and it was previously identified as eQTL in healthy controls. NDFIP1 shows interesting immune functions and is involved in the development of the central nervous system. We aimed at studying the NDFIP1 variant on activation and metabolism of immune cells. NDFIP1 mRNA and protein expression were assessed in PBMCs by qPCR and western blot in 87 MS patients and 84 healthy controls genotyped for rs4912622. Immune activation after PHA stimulation was evaluated by CD69 upregulation, and metabolic function of both basal and PHA-activated lymphocytes was studied by Seahorse Xfp-Analyzer. In minor-allele homozygous controls but not in patients, we found higher NDFIP1 expression, significantly reduced protein levels, and CD69 upregulation in B- and T-cells. PBMCs from minor-allele homozygous controls showed significantly higher basal mitochondrial respiration and ATP production compared to major-allele carriers, while minor-allele homozygous patients showed significantly lower metabolic activity than carriers of the major allele. In conclusion, we describe associations in minor-allele homozygous controls with lower levels of NDFIP1 protein, CD69 upregulation, and raised mitochondrial activity, which are not replicated in MS patients, suggesting a NDFIP1 differential effect in health and disease.
A novel method quantifying caries following orthodontic treatment
Authors: Erbe Christina , Hartmann Luisa , Schmidtmann Irene , Ohlendorf Daniela , Wehrbein Heinrich 
Published: November 2021

AbstractThis retrospective pilot study used a newly developed evaluation tool to assess the prevalence and incidence of White Spot Lesions (WSL) before and after multibracket appliance (MB) therapy. Digital photographs of 121 adolescent patients (63 ♂, 58 ♀) with metal brackets were analyzed retrospectively before and after MB therapy. The labial surfaces of anterior teeth, canine teeth, and premolars in the upper (UJ) and lower jaws (LJ) were evaluated using the Enamel Decalcification Index (EDI) by Banks and Richmond (Eur J Orthod, 16(1):19–25, 1994, levels 0–3) and a specially developed digitally scaled graticule with concentric circles to quantify the extent of WSL (in %). The statistical data analysis was based on crosstabulations and logistic regression. Before MB, 69.4% of the patients presented at least one WSL and 97.5% after, an increase of 28.1%. Before MB, 18.4% of the tooth surfaces (TS) showed an EDI level of 1–3. After MB, 51.8% of the TS featured WSL. 18.2% of the TS showed a WSL to the extent of ≥ 20–100% before and 52.3% after MB. The incidence in the UJ (71–79%) as well as the LJ (64–76%) was highest for the first and second premolars and lowest for LJ incisors (22–35%). The probability for developing a new distal WSL is higher than developing gingival, mesial or occlusal WSL. Labial MB therapy drastically increases the risk of developing WSL. We verified a concise quantification of the extent of labial WSL with the evaluation index.
Heterostrain-enabled dynamically tunable moiré superlattice in twisted bilayer graphene
Authors: Gao Xuejiao , Sun Hao , Kang Dong-Ho , Wang Chongwu , Wang Qi Jie , Nam Donguk 
Published: November 2021

AbstractThe ability to precisely control moiré patterns in two-dimensional materials has enabled the realization of unprecedented physical phenomena including Mott insulators, unconventional superconductivity, and quantum emission. Along with the twist angle, the application of independent strain in each layer of stacked two-dimensional materials—termed heterostrain—has become a powerful means to manipulate the moiré potential landscapes. Recent experimental studies have demonstrated the possibility of continuously tuning the twist angle and the resulting physical properties. However, the dynamic control of heterostrain that allows the on-demand manipulation of moiré superlattices has yet to be experimentally realized. Here, by harnessing the weak interlayer van der Waals bonding in twisted bilayer graphene devices, we demonstrate the realization of dynamically tunable heterostrain of up to 1.3%. Polarization-resolved Raman spectroscopy confirmed the existence of substantial heterostrain by presenting triple G peaks arising from the independently strained graphene layers. Theoretical calculations revealed that the distorted moiré patterns via heterostrain can significantly alter the electronic structure of twisted bilayer graphene, allowing the emergence of multiple absorption peaks ranging from near-infrared to visible spectral ranges. Our experimental demonstration presents a new degree of freedom towards the dynamic modulation of moiré superlattices, holding the promise to unveil unprecedented physics and applications of stacked two-dimensional materials.
Collateral estimation by susceptibility-weighted imaging and prediction of functional outcomes after acute anterior circulation ischemic stroke
Authors: Lee Hyung Jin , Roh Hong Gee , Lee Sang Bong , Jeon Yoo Sung , Park Jeong Jin , Lee Taek-Jun , Jung Yu Jin , Choi Jin Woo , Chun Young Il , Ki Hee Jong , Cho Junsoo , Lee Ji Sung , Kim Hyun Jeong 
Published: November 2021

AbstractTo determine the value of susceptibility-weighted imaging (SWI) for collateral estimation and for predicting functional outcomes after acute ischemic stroke. To identify independent predictors of favorable functional outcomes, age, sex, risk factors, baseline National Institutes of Health Stroke Scale (NIHSS) score, baseline diffusion-weighted imaging (DWI) lesion volume, site of steno-occlusion, SWI collateral grade, mode of treatment, and successful reperfusion were evaluated by multiple logistic regression analyses. A total of 152 participants were evaluated. A younger age (adjusted odds ratio (aOR), 0.42; 95% confidence interval (CI) 0.34 to 0.77; P < 0.001), a lower baseline NIHSS score (aOR 0.90; 95% CI 0.82 to 0.98; P = 0.02), a smaller baseline DWI lesion volume (aOR 0.83; 95% CI 0.73 to 0.96; P = 0.01), an intermediate collateral grade (aOR 9.49; 95% CI 1.36 to 66.38; P = 0.02), a good collateral grade (aOR 6.22; 95% CI 1.16 to 33.24; P = 0.03), and successful reperfusion (aOR 5.84; 95% CI 2.08 to 16.42; P = 0.001) were independently associated with a favorable functional outcome. There was a linear association between the SWI collateral grades and functional outcome (P = 0.008). Collateral estimation using the prominent vessel sign on SWI is clinically reliable, as it has prognostic value.
New perspectives for neutron imaging through advanced event-mode data acquisition
Authors: Losko A. S. , Han Y. , Schillinger B. , Tartaglione A. , Morgano M. , Strobl M. , Long J. , Tremsin A. S. , Schulz M. 
Published: November 2021

AbstractImaging using scintillators is a widespread and cost-effective approach in radiography. While different types of scintillator and sensor configurations exist, it can be stated that the detection efficiency and resolution of a scintillator-based system strongly depend on the scintillator material and its thickness. Recently developed event-driven detectors are capable of registering spots of light emitted by the scintillator after a particle interaction, allowing to reconstruct the Center-of-Mass of the interaction within the scintillator. This results in a more precise location of the event and therefore provides a pathway to overcome the scintillator thickness limitation and increase the effective spatial resolution of the system. Utilizing this principle, we present a detector capable of Time-of-Flight imaging with an adjustable field-of-view, ad-hoc binning and re-binning of data based on the requirements of the experiment including the possibility of particle discrimination via the analysis of the event shape in space and time. It is considered that this novel concept might replace regular cameras in neutron imaging detectors as it provides superior detection capabilities with the most recent results providing an increase by a factor 3 in image resolution and an increase by up to a factor of 7.5 in signal-to-noise for thermal neutron imaging.
Efficacy of chemotherapy for malignant pleural mesothelioma according to histology in a real-world cohort
Authors: Cedres Susana , Assaf Juan-David , Iranzo Patricia , Callejo Ana , Pardo Nuria , Navarro Alejandro , Martinez-Marti Alex , Marmolejo David , Rezqallah Alejandra , Carbonell Caterina , Frigola Joan , Amat Ramon , Pedrola Anna , Dienstmann Rodrigo , Felip Enriqueta 
Published: November 2021

AbstractCheckMate 743 trial demonstrated survival benefit of immunotherapy in first line in MPM with some differences in the efficacy of chemotherapy according to histology. The objective of this study is to characterize the impact of chemotherapy according to histology in patients diagnosed with MPM at our institution. Clinical records of all MPM patients diagnosed at Vall d’Hebron University Hospital between November 2002 and April 2020 were reviewed. Associations between clinical variables and outcomes were assessed with Cox regression models. Survival data were calculated by the Kaplan–Meier method. 189 patients were included with 76% of tumors classified as epithelioid subtype. First line chemotherapy was offered to 85% of patients. Median survival in overall population was 21.3 months (95% CI 17.2–24.3). We found that patients with epithelioid tumors had better overall survival (OS) and progression free survival (PFS). Median OS of epithelioid patients treated with first line chemotherapy was 26.7 months versus 15.0 months in non-epithelioid patients (HR 2.25 CI 95% 1.4–3.4; p < 0.001). Median PFS for patients with epithelioid tumors treated with chemotherapy was 4.8 months versus 3.6 months in non-epithelioid (HR 1.5 CI 95% 1.0–2.3; p = 0.03). The improvement of outcomes in patients with epithelioid histology was detected in patients treated with cisplatin or carboplatin. Histology was not a predictive factor for the platinum agent sensitivity (p of interaction PFS = 0.09, p of interaction OS = 0.65). In our series, patients with non-epithelioid tumors presented worse prognosis. Although epithelioid tumors exposed to cisplatin had higher PFS, histology was not a clear predictor of chemotherapy efficacy.
Impact of GAN-based lesion-focused medical image super-resolution on the robustness of radiomic features
Authors: de Farias Erick Costa , di Noia Christian , Han Changhee , Sala Evis , Castelli Mauro , Rundo Leonardo 
Published: November 2021

AbstractRobust machine learning models based on radiomic features might allow for accurate diagnosis, prognosis, and medical decision-making. Unfortunately, the lack of standardized radiomic feature extraction has hampered their clinical use. Since the radiomic features tend to be affected by low voxel statistics in regions of interest, increasing the sample size would improve their robustness in clinical studies. Therefore, we propose a Generative Adversarial Network (GAN)-based lesion-focused framework for Computed Tomography (CT) image Super-Resolution (SR); for the lesion (i.e., cancer) patch-focused training, we incorporate Spatial Pyramid Pooling (SPP) into GAN-Constrained by the Identical, Residual, and Cycle Learning Ensemble (GAN-CIRCLE). At $$2\times $$

2
×

SR, the proposed model achieved better perceptual quality with less blurring than the other considered state-of-the-art SR methods, while producing comparable results at $$4\times $$

4
×

SR. We also evaluated the robustness of our model’s radiomic feature in terms of quantization on a different lung cancer CT dataset using Principal Component Analysis (PCA). Intriguingly, the most important radiomic features in our PCA-based analysis were the most robust features extracted on the GAN-super-resolved images. These achievements pave the way for the application of GAN-based image Super-Resolution techniques for studies of radiomics for robust biomarker discovery.
Species invasion progressively disrupts the trophic structure of native food webs
Authors: Wainright Charles A. , Muhlfeld Clint C. , Elser James J. , Bourret Samuel L. , Devlin Shawn P. 
Published: November 2021

Significance
Invasive species are a leading cause of biodiversity loss, yet the mechanisms by which invaders progressively disrupt ecosystems and native species remain unclear. Using an extensive isotope dataset across multiple ecosystems and stages of invasion, we show that an invasive fish predator (lake trout) disrupted food webs by forcing native fishes to feed on suboptimal food sources in different habitats, resulting in the functional extirpation of the native predator, threatened bull trout. Our results provide insights into the magnitude, direction, and timing of food web disruption from invasive species and will be important for predicting ecosystem consequences of species invasions.