bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lifestyle segmentation of Czech food consumers: how sustainability and listening to music correspond to consumer lifestyles
Authors: Hrubá Renata , Sadílek Tomáš 
Published: March 2021

PurposeThe purpose of this study is to segment Czech consumers based on their sustainable food consumption and their relationship with listening to music. Specifically, the authors attempt to answer the following question: is the relationship to music a segmentation difference for young consumers in the case of sustainability? The food-related lifestyle (FRL) concept is used as a framework; little attention has been paid to the FRL profile in the context of certain types of consumer orientations toward sustainability as a social value among consumers in Czechia.Design/methodology/approachIn this research, the authors used 22 items related to sustainability (identify sustainability-oriented and health-oriented variables and socially and ethically oriented variables). The statistical data analysis techniques included factor analysis and cluster analysis. The results of the cluster analysis are the market segments. The total sample consists of 331 university students from Czechia. These data are from a continuous research project. A factor analysis identified six factors with satisfactory reliability coefficients. Using factor scores, a cluster analysis was run, resulting in four segments. These segments were further analyzed and described toward their sustainability orientation.FindingsFRL concept was used to evaluate whether there are differences in the profiles of consumer orientations. Results emphasize the importance of personal characteristics and attitudes toward music, which in turn affect strategies to communicate with different segments to promote sustainable foods. Each segment has statistically significant differences in terms of its FRL.Originality/valueThis study explores the link between attitudes and behavior and suggests strategies to better understand the effect of information on consumer behavior. The results can help practitioners develop labeling strategies for fair-trade and sustainable foods to better focus on specific segments of consumers. This can be relevant when a sustainable food market is just starting, but hopes to reach more maturity in Czechia should be of the utmost importance for investors making long-term investments.
The potential of feminist technoscience for advancing research in information practice
Authors: Costello Kaitlin Light , Floegel Diana 
Published: March 2021

PurposeIn this paper, we introduce feminist technoscience as an approach that will advance theory in information behavior and practice.Design/methodology/approachIn this conceptual paper, we identify four common assumptions in information behavior and information practice research that limit theory development to date. Existing models and theories tend to rely on extractive logic, focus on a person-in-situation, depend on binary definitions and assume that information interaction changes people's lives for the better. This leads to extractive ways of discussing information interactions and limits our ability to fully theorize embodiment and affect in our discipline.FindingsFeminist technoscience offers distinct ways of thinking about people, technology, bodies and power; in doing so, it responds to some perennial limitations in our research to date.Originality/valueFeminist technoscience is a robust research paradigm that has not yet been fully applied in our discipline. Assumptions in information behavior and information practice research have led to models and theories that reflect a logic of extraction and are limited in their potential for characterizing both embodiment and affect. Feminist technoscience provides a way to conduct research that challenges these assumptions and addresses these limitations.
Sodium butyrate ameliorates non‐alcoholic fatty liver disease by upregulating miR‐150 to suppress CXCR4 expression
Authors: Zhang Ning , Qu Yunfei , Qin Bo 
Published: March 2021

AbstractSodium butyrate (NaB) in the gut of animals possesses the potential to modulate lipid metabolism, regulate innate immunity and protect intestinal health. Accumulating data have supported the important function of metabolites of intestinal microflora (MIM) in non‐alcoholic fatty liver disease (NAFLD). This study intended to investigate the role of NaB in NAFLD and its specific mechanism. Mice were fed a high‐fat diet (HFD) for 16 weeks to establish the NAFLD mouse model. The mice were intragastrically administrated MIM (200 µL/day) or NaB (200 mg/kg/day) by gavage for another 8 weeks. The morphology of liver tissues was observed by hematoxylin and eosin (H&E) staining, and the lipid deposition of liver tissues was examined by oil red O staining. The NAFLD cell model was constructed in alpha mouse liver 12 (AML12) cells by 24 hours of stimulation with 0.5 mM free fatty acids. After treatment with 10 mM NaB, AML12 cells were transfected with mimic‐miR‐150 or inhibitor‐miR‐150. Quantitative real‐time polymerase chain reaction (qRT‐PCR) and western blotting were used to measure the contents of interleukin 1β (IL‐1β), IL‐6 and tumour necrosis factor α (TNF‐α) and the expression of microRNA (miR)‐150 and CXCR4 in liver tissues of mice and in AML12 cells. A luciferase reporter assay was applied to verify the binding relationship between miR‐150 and CXCR4. The H&E and oil red O staining results showed hepatic steatosis in the liver tissues of HFD‐fed mice. There were elevated contents of triacylglycerides (TG), total cholesterol (TC), high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C), fasting blood glucose, enhanced activities of alanine aminotransferase(ALT) and aspartate aminotransferase(AST), increased homeostatic model assessment of insulin resistance scores and increased inflammatory responses in the serum of HFD‐fed mice. However, intervention with MIM or NaB reversed the above trends, indicating that MIM or NaB intervention relieved hepatic steatosis in mice. HFD‐fed mice had downregulated expression of miR‐150, whereas the expression level was upregulated after MIM or NaB treatment. Sodium butyrate attenuated NAFLD progression by regulating miR‐150. MiR‐150 can negatively target CXCR4. Sodium butyrate mitigates HFD‐induced NAFLD in mice by upregulating miR‐150 expression to downregulate CXCR4.
Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review
Authors: Alasalvar Cesarettin , Chang Sui Kiat , Bolling Bradley , Oh Won Young , Shahidi Fereidoon 
Published: March 2021

AbstractSeeds play important roles in human nutrition and health since ancient time. The term “specialty” has recently been applied to seeds to describe high‐value and/or uncommon food products. Since then, numerous studies have been conducted to identify various classes of bioactive compounds, including polyphenols in specialty seeds. This review discusses nutrients, fat‐soluble bioactives, polyphenols/bioactives, antioxidant activity, bioavailability, health benefits, and safety/toxicology of commonly consumed eight specialty seeds, namely, black cumin, chia, hemp, flax, perilla, pumpkin, quinoa, and sesame. Scientific results from the existing literature published over the last decade have been compiled and discussed. These specialty seeds, having numerous fat‐soluble bioactives and polyphenols, together with their corresponding antioxidant activities, have increasingly been consumed. Hence, these specialty seeds can be considered as a valuable source of dietary supplements and functional foods due to their health‐promoting bioactive components, polyphenols, and corresponding antioxidant activities. The phytochemicals from these specialty seeds demonstrate bioavailability in humans with promising health benefits. Additional long‐term and well‐design human intervention trials are required to ascertain the health‐promoting properties of these specialty seeds.
Long‐term stability of sex chromosome gene content allows accurate qPCR‐based molecular sexing across birds
Authors: Mazzoleni Sofia , Němec Pavel , Albrecht Tomáš , Lymberakis Petros , Kratochvíl Lukáš , Rovatsos Michail 
Published: March 2021

AbstractEmbryos, juveniles, and even adults of many bird species lack pronounced external sexually dimorphic characteristics. Accurate identification of sex is crucial for research (e.g., developmental, population, and evolutionary studies), management of wildlife species, and captive breeding programmes for both conservation and poultry. An accurate molecular sexing method applicable across the entire bird radiation is theoretically possible thanks to the long‐term stability of their ZZ/ZW sex chromosomes, but current methods are not applicable in a wide range of bird lineages. Here, we developed a novel molecular sexing method based on the comparison of gene copy number variation by quantitative real‐time PCR (qPCR) in conserved Z‐specific genes (CHRNA6,DDX4,LPAR1,TMEM161B,VPS13A), i.e. genes linked to Z but absent from W chromosomes. We tested the method across three paleognath and 70 neognath species covering the avian phylogeny. In addition, we designed primers for four Z‐specific genes (DOCK8,FUT10,PIGGandPSD3) for qPCR‐based molecular sexing in three paleognath species. We have demonstrated that the genesDOCK8,FUT10,PIGGandPSD3can identify sex in paleognath birds and the genesCHRNA6,DDX4,TMEM161B, andVPS13Acan reveal sex in neognath birds. The geneLPAR1can be used to accurately identify sex in both paleognath and neognath species. Along with outlining a novel method of practical importance for molecular sexing in birds, our study also documents in detail the conservation of sex chromosomes across the avian phylogeny.
Left ventricular hypertrophy predicts poorer cardiovascular outcome in normotensive normoglycemic patients with rheumatoid arthritis
Authors: Cioffi Giovanni , Viapiana Ombretta , Orsolini Giovanni , Ognibeni Sonographer Federica , Dalbeni Andrea , Gatti Davide , Adami Giovanni , Fassio Angelo , Rossini Maurizio , Giollo Alessandro 
Published: March 2021

AbstractIntroductionPatients with rheumatoid arthritis (RA) develop early changes in left ventricular (LV) geometry and experience cardiovascular events in excess than in the general population. This study was designed to assess prevalence, predictors and prognostic role of LV hypertrophy (LVH) in a selected group of RA patients with normal blood pressure and glycemia who should be at low risk for LVH.MethodsWe prospectively analyzed 241 normotensive normoglycemic RA patients (mean age 53 ± 12 years, 61% women) involved in a primary prevention program for cardiovascular diseases who were followed‐up for 40 (24‐56) months. LVH was detected by echocardiography and defined as LV mass ≥49.2 g/m2.7 for men and ≥46.7 g/m2.7 for women. Primary outcome was a composite of cardiovascular death/hospitalization.ResultsLVH was detected in 39 patients (16%). Older age (>53 years), greater body mass index (BMI > 25 kg/m2), longer duration of RA disease, anti‐cyclic citrullinated peptide antibody (ACPA) positivity and concentric LV geometry were the variables associated with LVH. During the follow‐up, a cardiovascular event occurred in 12 of 39 (31%) patients with LVH and in 22 of 202 (11%; P < .001) patients without LVH. LVH independently predicted cardiovascular events (hazards ratio 3.28 [95% CI 1.03‐9.20], P = .03) at Cox regression analysis together with C‐reactive protein and ACPA positivity.ConclusionsNearly one‐sixth of normotensive normoglycemic RA patients analyzed in a primary prevention program for cardiovascular diseases has LVH which is associated with obesity and older age, and strongly predicts cardiovascular event in these subjects.
PA28α overexpressing female mice maintain exploratory behavior and capacity to prevent protein aggregation in hippocampus as they age
Authors: Adelöf Julia , Wiseman John , Zetterberg Madeleine , Hernebring Malin 
Published: March 2021

AbstractWith age, protein damage accumulates and increases the risk of age‐related diseases. The proteasome activator PA28αβ is involved in protein damage clearance during early embryogenesis and has demonstrated protective effects against proteinopathy. We have recently discovered that adult female mice overexpressing PA28α (PA28αOE) have enhanced learning and memory, and protein extracts from their hippocampi prevent aggregation more efficiently than wild type. In this study, we investigated the effect of overexpressing PA28α on aging using C57BL/6N×BALB/c F2 hybrid mice. We found that the hippocampal anti‐aggregation effect was maintained in young adult (7 months) to middle‐aged (15 months) and old (22 months) PA28αOE females. While the PA28αOE influence on learning and memory gradually decreased with aging, old PA28αOE females did not display the typical drop in explorative behavior—a behavioral hallmark of aging—but were as explorative as young mice. PA28αOE lowered PA28‐dependent proteasome capacity in both heart and hippocampus, and there was no indication of lower protein damage load in PA28αOE. The life span of PA28αOE was also similar to wild type. In both wild type and PA28αOE, PA28‐dependent proteasome capacity increased with aging in the heart, while 26S and 20S proteasome capacities were unchanged in the timepoints analyzed. Thus, PA28αOE females exhibit improved hippocampal ability to prevent aggregation throughout life and enhanced cognitive capabilities with different behavioral outcomes dependent on age; improved memory at early age and a youth‐like exploration at old age. The cognitive effects of PA28αβ combined with its anti‐aggregation molecular effect highlight the therapeutical potential of PA28αβ in combating proteinopathies.
Skin shop: long‐term management and follow‐up of narrowly and incompletely excised non‐melanomatous skin cancer
Authors: Lee Young , Yang Cliff , Adams Brandon 
Published: March 2021

AbstractBackground‘Skin Shop’ is a model of care at a high‐volume tertiary centre that describes a registrar‐lead skin cancer service under consultant supervision. Ninety‐two percent of lesions are completely excised, 4.2% are narrowly excised and 3.2% are incompletely excised. Current international guidelines suggest re‐excision of incompletely excised non‐melanomatous skin cancer (NMSC); however, there is a lack of robust evidence to suggest how these lesions should be optimally managed. We describe how narrow and incompletely excised NMSC are managed in the ‘Skin Shop’ and present rates of recurrence.MethodsRetrospective analysis of all lesions excised between December 2014 and June 2019. Lesion type, histological margin, presence of high‐risk features, management, presence of residual tumour in re‐excision and follow‐up duration were recorded. Rates of clinical recurrence were documented.ResultsFrom 5821 lesions excised, a total of 394 NMSC (245 basal cell carcinoma (BCC), 128 squamous cell carcinoma (SCC) and 21 Basosquamous cell carcinoma) were narrowly or incompletely excised. A total of 135 (34.3%) lesions were observed in clinic for recurrence, 133 (33.8%) lesions underwent re‐excision, 81 (20.6%) lesions underwent GP surveillance and 14 (3.6%) lesions received radiotherapy. Mean specialist clinic follow‐up was 12.4 months. Fourteen lesions recurred (3.5%, 10 BCC, 3 SCC, 1 basosquamous) of which 12 underwent re‐excision. The risk of recurrence for narrow and incompletely excised BCC was 2.9% and 10%, respectively. The corresponding rates for SCC were 2.2% and 3.3%, respectively.ConclusionSkin Shop is an effective model with low rates of narrow and incompletely excised NMSC. Risk of recurrence of these lesions is low with our current practice.
Female genital mutilation/cutting, timing of deinfibulation, and risk of cesarean section
Authors: Taraldsen Sølvi , Vangen Siri , Øian Pål , Sørbye Ingvil K. 
Published: March 2021

AbstractIntroductionThe impact of female genital mutilation/cutting on obstetric outcomes in high‐income countries is not clear. In general, women with female genital mutilation/cutting type 3 (infibulation) seem to be most at risk of adverse outcomes such as cesarean section. Deinfibulation is recommended to prevent obstetric complications. Whether the timing of this procedure affects the complication risk is not known. The aims of this study were, first, to examine the association between female genital mutilation/cutting and the risk of cesarean section in Norway, and, second, whether the timing of deinfibulation affected the cesarean section risk.Material and methodsThis was a historical cohort study of nulliparous Somali‐born women who gave birth in Norway between 1990 and 2014. The Medical Birth Registry of Norway identified the women. Data were collected from medical records at 11 participating birth units. The exposures were female genital mutilation/cutting status and deinfibulation before pregnancy, during pregnancy, or no deinfibulation before labor onset. The main outcome was odds ratio (OR) of cesarean section. Type of cesarean section, primary indications, and neonatal outcomes were secondary outcomes.ResultsWomen with female genital mutilation/cutting type 3 had lower risk of cesarean section compared with women with no female genital mutilation/cutting (OR 0.54, 95% CI 0.33‐0.89 P = .02). Among the 1504 included women, the cesarean section rate was 28.0% and the proportion of emergency operations was 92.9%. Fetal distress was the primary indication in approximately 50% of cases, across the groups with different female genital mutilation/cutting status. Women who had no deinfibulation before labor onset had lower risk of cesarean section compared with those who underwent deinfibulation before or during pregnancy (OR 0.64, 95% CI 0.46‐0.88 P = .01).ConclusionsHigh risk of cesarean section in Somali nulliparous women was not related to the type of female genital mutilation/cutting in the present study. Deinfibulation before labor did not protect against cesarean section. Our findings indicate that nulliparous Somali women are at high risk of intrapartum complications. Future research should focus on measures to reduce maternal morbidity and on how timing of deinfibulation affects the outcomes of vaginal births.
The incidence of brain lesions in central precocious puberty: The main cause for Chinese boys was idiopathic
Authors: Wang Jinling , Zhan Shumin , Yuan Jinna , Ullah Rahim , Dong Guanping , Wu Wei , Huang Ke , Fu Junfen 
Published: March 2021

AbstractObjectiveMany studies show that brain lesions are the main cause of central precocious puberty (CPP) in males. However, the association rate has not been reported in China. This study aimed to assess the frequency of both abnormal and likely pathologic brain lesions by magnetic resonance imaging (MRI) in Chinese boys with CPP.DesignThis is a retrospective cross‐sectional single‐centre study.Patients396 CPP boys were recruited from 2011 to 2019 in Children's Hospital, Zhejiang University School of Medicine, and 129 were eligible for our study.MeasurementsDiagnosis age, bone age, weight (kg), height (cm), puberty stage, MRI results and levels of sexual hormone were analysed.ResultsThe number of CPP boys is increasing from 2011 to 2019 in China. Brain MRI findings were normal in 83.7% of CPP boys. Only 21 (16.3%) CPP boys were found with abnormal MRI findings including hamartoma, pineal cyst and other minor changes.ConclusionIn China, there is an increasing trend of male CPP over the last decade and the main cause is idiopathic, rather than pathogenic brain lesions. Further investigations about the aetiology for CPP with pathological brain lesions are needed.
Surgical anatomy of the accessory middle colic artery: a meta‐analysis with implications for splenic flexure cancer surgery
Authors: Cheruiyot Isaac , Cirocchi Roberto , Munguti Jeremiah , Davies R Justin , Randolph Justus , Ndung’u Bernard , Henry Brandon Michael 
Published: March 2021

AbstractAimSurgical resection of splenic flexure cancers (SFCs) is technically demanding due to the complex regional anatomy, characterized by the presence of embryological adhesions, close proximity to the pancreas and spleen, and a highly heterogeneous arterial supply and lymphatic drainage. The accessory middle colic artery (AMCA) is increasingly being recognized as an important source of blood supply to the splenic flexure. The aim of this study is to determine the prevalence and anatomical features of the AMCA.MethodA systematic search of the scientific literature was conducted on PubMed and Embase from inception to November 2020 to identify potentially eligible studies. Data were extracted and prevalence was pooled into a meta‐analysis using MetaXL and Meta‐Analyst software.ResultsA total of 16 studies (n = 2203 patients) were included. The pooled prevalence (PP) of the AMCA was 25.4% (95% CI 18.1–33.4). Its prevalence was higher in patients without a left colic artery (LCA) (PP = 83.2%; 95% CI 70.4–93.1). The commonest origin for the AMCA was the superior mesenteric artery (PP = 87.9%; 95% CI 86.4–90.7). The AMCA shared a common trunk/gave rise to pancreatic branches in 23.1% of cases (95% CI 15.3–31.9).ConclusionThe AMCA contributes to the vascularization of the splenic flexure in approximately 25% of individuals, and may be an important feeder artery to SFCs, especially in the absence of a LCA. Preoperative identification of this artery is important to ensure optimal surgery for SFC and minimize complications.
Organ transplantation and outcomes in patients with a past history of melanoma: A systematic review and meta‐analysis
Authors: Williams Gabrielle Jean , Webster Angela C. , Thompson John F. 
Published: March 2021

AbstractBackgroundThe incidence of melanoma is steadily rising around the world. There is uncertainty about the safety of solid organ transplantation in patients with a prior history of melanoma.AimTo review studies reporting patients with a history of melanoma before solid organ transplantation.MethodsElectronic searches of Medline, Embase, and the Cochrane library up to March 2020. All study designs, in any language and without sample size restriction, were eligible for inclusion. Risk of bias was assessed using established tools, and meta‐analysis was performed using a random‐effects model.ResultsWe identified 41 studies reporting 703 100 transplant recipients and 1692 had pre‐transplantation melanomas. Risk of death, expressed as a hazard ratio, in patients with pre‐transplantation melanoma relative to those without prior melanoma, was 1.32 (95% CI: 1.09–1.59). After transplantation, 13.1% of patients with pre‐transplantation melanoma developed new or recurrent melanoma (IQR: 4.8%–18.2%).ConclusionsAround 1‐in‐400 transplant recipients had a prior history of melanoma. This was associated with a greater than 1‐in‐10 risk of new or recurrent melanoma after transplantation and an increased risk of death. A 5‐year waiting time between a melanoma diagnosis and transplantation has been recommended based on historic registry data, but very little additional information is available to justify or revise this.