bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemodynamic determinants of left atrial strain in patients with hypertrophic cardiomyopathy: A combined echocardiography and CMR study
Authors: Tayal Bhupendar , Malahfji Maan , Buergler John M. , Shah Dipan J. , Nagueh Sherif F. 
Published: February 2021

Background
Left atrial (LA) strain is associated with symptomatic status and atrial fibrillation in patients with hypertrophic cardiomyopathy (HCM). However, hemodynamic determinants of LA reservoir (LARS), conduit, and pump strains have not been examined and data are needed on the relation of LA strain with exercise tolerance in HCM.

Methods
Fifty HCM patients with echocardiographic and CMR imaging within 30 days were included. Left ventricular (LV) volumes, mass, EF, scar extent, extracellular volume fraction (ECV), and LA maximum volume were measured by CMR. Echo studies were analyzed for mitral inflow, pulmonary vein flow, mitral annulus tissue Doppler velocities, LV global longitudinal strain, and LA strain. Twenty six patients able and willing to exercise underwent cardiopulmonary stress testing for peak oxygen consumption (MVO2), and VE/VCO2 slope. Patients were followed for clinical events.

Findings
LARS was significantly associated with indices of LA systolic function, LV GLS, and LV filling pressures (P<0.05). Conduit strain was significantly associated with mitral annulus early diastolic velocity and ECV, whereas LA pump strain was determined by LA systolic function and indices of LV end diastolic pressure (all P<0.05). LARS and conduit strain were significantly higher in patients who achieved ≥80% of MVO2. LARS, conduit, and pump strains were significantly associated with atrial fibrillation (P<0.05).

Conclusions
LV structure, systolic and diastolic function, and LA systolic function determine the 3 components of LA strain. LA strain is associated with exercise tolerance and clinical events in patients with HCM.
Frequency and determinants of misuse of augmentation of labor in France: A population-based study
Authors: Girault Aude , Blondel Béatrice , Goffinet François , Le Ray Camille 
Published: February 2021

Introduction
While use of augmentation of labor (AL) is appropriate for labor dystocia, it is frequently used inadequately and unnecessarily. The objective was to assess at a national level, the frequency and determinants of misuse of augmentation of labor (AL).

Material and methods
Women of the French perinatal survey of 2016 with a singleton cephalic fetus, delivering at term after a spontaneous labor were included. “Misuse of AL” was defined by artificial rupture of the membranes (ROM) and/or oxytocin within one hour of admission and/or duration between ROM and oxytocin of less than one hour. Women, labor and maternity unit’s characteristics were compared between the “misuse of AL” and “no misuse of AL” groups by bivariate analysis. To identify the determinants of misuse of AL, a multivariable multilevel logistic regression was performed taking into account the data’s hierarchical structure (first level: women, second level: maternity units).

Results
Among the 7196 women included, 1524 (21.2%) had a misuse of AL. The determinants of misuse of AL were middle school educational level (reference high school), aOR = 1.21; 95%CI[1.01–1.45], gestational age at delivery ≥41weeks (reference 39–40 weeks), aOR = 1.19; 95%CI[1.00–1.42], cervical dilation ≥6cm at admission (reference <3cm), aOR = 1.39; 95%CI[1.10–1.76], epidural analgesia aOR = 1.63; 95%CI[1.35–1.96], delivery in a private hospital (reference public teaching hospital), aOR = 2.25; 95%CI[1.57–3.23]; and maternity units with <1000 deliveries/year and 1000–1999 deliveries/year (reference ≥3000 deliveries/year), respectively aOR = 1.52; 95%CI[1.11–2.08] and aOR = 1.42; 95%CI[1.05–1.92]. Less than 3% of the variance was explained by women characteristics, and 24.17% by the maternity units’ characteristics.

Conclusions
In France, one spontaneous laboring woman among five is subject to misuse of AL. The misuse is mostly explained by maternity unit’s characteristics. The determinants identified in this study can be used to implement targeted actions in small and private maternity units.
The impact of cataract progression on accuracy of intraocular lens power measurement
Authors: Leng Lin , Li Honglei , Yin Min , Gao Han , Shao Ting , Long Keli 
Published: February 2021

Purpose
The aim of this study was to assess the impact of cataract progression using the Haigis formula-calculated intraocular lens (IOL) power and investigate the accuracy of IOL power measured at different time points.

Methods
This prospective study was performed on 75 eyes of 75 patients who underwent uneventful cataract surgery. Preoperative ocular parameters including axial length (AL), keratometry (K), anterior chamber depth (ACD), corneal astigmatism, corrected distance visual acuity (CDVA) and uncorrected distance visual acuity (UDVA) examined at the two time points, more than 3 months preoperatively and preoperative 1 day were compared. The ocular parameters measured in the two time points were used to calculate the predicted implanted IOL power and the actual IOL power was chosen on the basis of parameters measured earlier before surgery using the Haigis formula. The mean numerical error (MNE) and mean absolute error (MAE) predicted by the two time points were also compared.

Results
There were significant differences in the ACD, IOL power, UDVA and CDVA (P<0.01), but no statistical differences in AL, mean K and corneal astigmatism (P>0.05) during the average of 5.6 months before surgery. No statistically significant difference was detected in MNE (P>0.05), while the MAE had a significant difference in the two time points (P<0.05).

Conclusion
The IOL power measured earlier before surgery might result in a higher accuracy and the postoperative refractive outcome tended towards emmetropia.
Contenido preventivo en la negociación colectiva
Authors: Poquet Catala Raquel 
Published: February 2021

En este trabajo se realiza un análisis cualitativo y cuantitativo de los convenios colectivos de ámbito estatal de los dos últimos años y medio en cuanto a la regulación que contienen sobre la materia de seguridad y salud laboral. En este sentido, se procede a estudiar con detalle la regulación convencional sobre la formación, vigilancia de la salud, órganos de representación de los trabajadores, colectivos con protección especial y nuevos riesgos emergentes, en concreto, el acoso moral. Se concluye en general, que, desafortunadamente, y aunque se ha conseguido un avance importante al respecto, en los momentos actuales, y en general, la materia preventiva aún no ha tenido un adecuado reflejo en la negociación colectiva, ni siquiera en aquellos casos en los que la LPRL realiza un llamamiento expreso a la normativa convencional. Es decir, los resultados de la negociación colectiva en esta materia no son suficientes, pues la mayoría de los convenios se remiten simplemente a la LPRL, mediante meras declaraciones retóricas sobre la importancia de la misma, sin proponer una regulación adecuada y sistemática de la misma y, más en concreto, de las peculiaridades y particularidades de su sector productivo, cuando la finalidad de los mismos es concretamente ello.
Factors Enhancing Treatment of Hepatitis C Virus–Infected Italian People Who Use Drugs: The CLEO-GRECAS Experience
Authors: Rinaldi Luca , Messina Vincenzo , Di Marco Vito , Iovinella Vincenzo , Claar Ernesto , Cariti Giuseppe , Sacco Rodolfo , De Luca Massimo , Scifo Gaetano , Gatti Pietro , Barbarini Giorgio , Pace Palitti Valeria , Quartini Mariano , Tundo Paolo , D'Offizi Gianpiero , Parruti Giustino , di Rosolini Maria Antonietta , Garrucciu Giovanni , Cosco Lucio , Benanti Francesco , Gimignani Giancarlo , Vespasiani Gentilucci Umberto , Di Lorenzo Francesco , D'Antò Maria , Nevola Riccardo , Lupia Tommaso , Rosato Valerio , Morbiducci Valeria , Luzzitelli Ilaria , Sozio Federica , Di Stefano Marco , Ciraci Emanuela , Bulla Fabio , Guarisco Riccardo , Cangiano Cecilia , Imparato Michele , Maggi Paolo , Ascione Antonio , Craxì Antonio , Izzi Antonio 
Published: February 2021

INTRODUCTION:
We assessed the performance of direct-acting antivirals (DAAs) in hepatitis C virus (HCV)-infected people who use drugs (PWUDs) in terms of sustained virological response (SVR) and adherence rates in comparison to a location-matched cohort of non-PWUD HCV patients.

METHODS:
All consecutive HCV RNA-positive PWUDs were enrolled between 2015 and 2019. All subjects underwent DAA treatment according to international guidelines and then followed, at least, up to 12 weeks after the end of treatment (SVR12). The SVR and adherence to treatment was compared with that of non-PWUD HCV patients observed at hepatological units of the CLEO platform. Intention-to-treat analysis was performed.

RESULTS:
A total of 1,786 PWUDs who were followed up were available for assessment. Most PWUDs (85.4%) were managed inside the specialized outpatient addiction clinics (SerDs). The overall SVR rate was 95.4%. The SerDs group achieved an SVR rate of 96.2% compared with 91.6% of the non-SerDs group (P < 0.001). Comparison with the non-SerDs group and the control HCV group showed a significant difference in the dropout rate (0.6% in the SerDs group versus 2.8% in the non-SerDs group and 1.2% in the control group; P < 0.001). At multivariate analysis, factors independently associated with SVR were use of the most recent regimens (elbasvir/grazoprevir, glecaprevir/pibrentasvir, and sofosbuvir/velpatasvir; odds ratio: 3.126; P = 0.000) and belonging to the SerDs group (odds ratio: 2.356; P = 0.002).

DISCUSSION:
The performance of DAAs in PWUD is excellent, if 2 conditions are met: (i) that the latest generation drugs are used and (ii) that the patients are managed within the SerDs.
Kobayashi—Hitchin correspondence for twisted vector bundles
Authors: Perego Arvid 
Published: February 2021

Abstract
We prove the Kobayashi—Hitchin correspondence and the approximate Kobayashi—Hitchin correspondence for twisted holomorphic vector bundles on compact Kähler manifolds. More precisely, if X is a compact manifold and g is a Gauduchon metric on X, a twisted holomorphic vector bundle on X is g−polystable if and only if it is g−Hermite-Einstein, and if X is a compact Kähler manifold and g is a Kähler metric on X, then a twisted holomorphic vector bundle on X is g−semistable if and only if it is approximate g−Hermite-Einstein.
Developing Computational Thinking Skills Through Modeling in Language Lessons
Authors: Rottenhofer Marina , Sabitzer Barbara , Rankin Thomas 
Published: February 2021

Abstract
Technology is rapidly changing the world around us and thus, there is a need to adjust education by teaching children skills that are required in the fast-paced digital life. One problem-solving skillset, which has gained considerable attention in the last couple of years, is computational thinking (CT). Up to now, many countries have already implemented CT as an integral part of their education curricula, however, there is still often the misconception that teaching CT requires high technical effort and profound knowledge of computer science. Whereas CT is useful in any subject, it is not necessarily linked to technology and helps children to tackle problems by applying skills that are used in computer science. One effective hands-on approach to foster CT in every subject is modeling. A model is a simplified and reduced version of the real world and modeling is the process of creating it. In this paper, the authors focus on fostering CT skills with models from the field of computer science (CS) in foreign language teaching. The authors present several CS models, that have proven to be useful in language teaching, demonstrate how this approach can foster CT skills and give an insight into their research.
Effects of Cryogenic Treatment on the Microstructure and Mechanical Properties of High-alloyed Tool Steels
Authors: Schulz Alwin , Cui Chengsong , Steinbacher Matthias , Ümit Tuncer , Wunde Martin , Jung Ingrid , Acar Serdal , Nürnberger Florian , Gerstein Gregory , Herbst Sebastian , Maier Hans Jürgen 
Published: February 2021

Abstract
In this work, the influence of a cryogenic treatment on the microstructure, mechanical properties and wear resistance of the high-alloyed tool steels X38CrMoV5-3, X153CrMoV12 and ~X190CrVMo20-4 were investigated. Based on tempering curves of the steels, the heat treatment parameters were determined for the mechanical and wear specimens so that the conventionally heat-treated steels and the cryogenically treated steels featured similar hardness. The investigations showed that an almost complete transformation of retained austenite and a more homogeneous distribution of secondary carbides in the microstructure could be achieved by incorporating a cryogenic treatment. However, the cryogenic treatment does not show significantly positive effects on the investigated mechanical properties and wear resistance of the tool steels. The wear resistance of the samples was dominated by primary carbides. The cryogenic treatment would have a positive effect on large tool components with large wall thicknesses in terms of uniform and complete transformation of retained austenite throughout the entire components.
Traditional knowledge to clinical trials: a review on nutritional and therapeutic potential of Pithecellobium dulce
Authors: Dhanisha Suresh Sulekha , Drishya Sudarsanan , Guruvayoorappan Chandrasekharan 
Published: February 2021

Abstract
The review describes botanical aspects, bioactive phytocompounds and pharmacological properties of different parts of Pithecellobium dulce, with special emphasis on the nutritional status of its fruits. The different parts of plant extract have been reported to possess anti-oxidant, anti-inflammatory, anti-microbial, anti-diabetic, cardio protective, anti-diarrhoeal, anti-ulcerogenic, larvicidal and ovicidal activities. Different parts of plant extracts were reported to contain several bioactive phytocompounds such as flavonoids, saponins, tannins, alkaloids etc. Natural products discovered so far served as a viable source for new drugs. Over the past few years, continued and perpetual attention of people has been paid to medicinal plants in connection with its remarkable importance in drug discovery. Plant products always remains a drug of choice for the identification of novel leads despite facing a tough competition from existing synthetic alternatives derived from combinatorial chemistry, owing to their efficacy, side effects, and safety. P. dulce is a highly acclaimed genus in traditional system of medicine because of its versatile nutraceutical and pharmacological properties. In this review we discuss in detail about nutritional and various therapeutic properties of P. dulce.
Potential anti-toxic effect of d-ribose-l-cysteine supplement on the reproductive functions of male rats administered cyclophosphamide
Authors: Oludare Gabriel O. , Afolayan Gbenga O. , Semidara Ganbotei G. 
Published: February 2021

Abstract

Objectives
This study aimed to access the protective effects of d-ribose-l-cysteine (DRLC) on cyclophosphamide (CPA) induced gonadal toxicity in male rats.

Methods
Forty-eight male Sprague-Dawley rats were divided into six groups of eight rats each. Group I the control, received distilled water (10 ml/kg), Group II received a single dose of CPA 100 mg/kg body weight intraperitoneally (i.p), Groups III and IV received a single dose of CPA at 100 mg/kg (i.p) and then were treated with DRLC at 200 mg/kg bodyweight (b.w) and 400 mg/kg b.w for 10 days, respectively. Rats in Groups V and VI received DRLC at 200 and 400 mg/kg b.w for 10 days, respectively. DRLC was administered orally.

Results
Results showed that CPA increased percentage of abnormal sperm cells and reduced body weight, sperm count, sperm motility, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone levels (p<0.05). CPA also induced oxidative stress as indicated by the increased malondialdehyde (MDA) content and reduced activities of the oxidative enzymes measured (p<0.05). Liver enzymes were elevated while the blood cells production was decreased in the rats administered CPA. DRLC supplementation enhanced the antioxidant defence system as indicated in the reduced MDA levels and increased activities of the antioxidant enzymes when compared with CPA (p<0.05). Bodyweight, sperm count, sperm motility, FSH, and testosterone levels were increased in the CPA + DRLC II group compared with CPA (p<0.05).

Conclusions
The results of this present study showed that DRLC has a potential protective effect on CPA-induced gonadotoxicity.
Suppress Me if You Can: Neurofeedback of the Readiness Potential
Authors: Schultze-Kraft Matthias , Jonany Vincent , Binns Thomas Samuel , Soch Joram , Blankertz Benjamin , Haynes John-Dylan 
Published: February 2021

AbstractVoluntary movements are usually preceded by a slow, negative-going brain signal over motor areas, the so-called readiness potential (RP). To date, the exact nature and causal role of the RP in movement preparation have remained heavily debated. Although the RP is influenced by several motorical and cognitive factors, it has remained unclear whether people can learn to exert mental control over their RP, for example, by deliberately suppressing it. If people were able to initiate spontaneous movements without eliciting an RP, this would challenge the idea that the RP is a necessary stage of the causal chain leading up to a voluntary movement. We tested the ability of participants to control the magnitude of their RP in a neurofeedback experiment. Participants performed self-initiated movements, and after every movement, they were provided with immediate feedback about the magnitude of their RP. They were asked to find a strategy to perform voluntary movements such that the RPs were as small as possible. We found no evidence that participants were able to to willfully modulate or suppress their RPs while still eliciting voluntary movements. This suggests that the RP might be an involuntary component of voluntary action over which people cannot exert conscious control.
Tindak Pidana Penipuan dan Pencucian Uang Yang Dilakukan Oleh PT. First Anugerah Karya Wisata (Studi Kasus : Putusan Nomor : 3096 K/Pid.Sus/2018)
Authors: Mawarni Iga Ayu , Asmawi Asmawi , Siradj Mustolih 
Published: February 2021

Penelitian ini bertujuan untuk menganalisa perampasan asset untuk negara dari PT First Anugerah Karya Wisata sudah sesuai dengan asas keadilan dan ketentuan hukum yang berlaku dan juga menjelaskan pertimbangan hukum hakim dalam menjatuhkan putusan serta mendeskripsikan hakim dalam menginterpretasikan pasal-pasal yang digunakan. Dari segi jenis penelitian hukum, jenis Tipe penelitian yang digunakan dalam penelitian ini adalah yuridis normatif, yaitu pendekatan yang mengacu kepada norma-norma hukum yang terdapat dalam peraturan perundang-undangan dan putusan-putusan pengadilan serta norma-norma hukum yang terdapat dalam masyarakat. Hasil dari penelitian ini menunjukkan bahwa apabila dilihat dari sisi korban tidak terpenuhinya rasa keadilan dalam putusan ini tidak juga ada kemanfaatan hukum yang terkandung dalam putusan ini. Mengingat sampai pada tingkat Kasasi, Hakim tetap menyatakan aset dirampas untuk negara yang sejatinya tidak ada sedikitpun kerugian negara yang dialami. Kata Kunci: Tindak Pidana, Penipuan, Pencucian Uang, Perampasan Aset.
Assessment of vibration amplitude and transmembrane pressure on vibratory shear enhanced membrane filtration for treating dairy wastewater
Authors: Szerencsés Sz. Gy. , Beszédes S. , László Zs. , Veréb G. , Szalay D. , Hovorkáné Horváth Zs. , Hodúr C. , Rákhely G. , Kertész Sz. 
Published: February 2021

AbstractIn this study, statistical analysis was performed to investigate the influence of operational parameters based on experimental results. The research aimed to know whether a long-term discontinuous module vibration operation is possible without adversely affecting filtration efficiency. Polymer membranes were compared by surface characteristics with contact angle measurements and selected for further membrane filtration experiments for dairy wastewater treatment. The effect of the main operational parameters, membrane module vibration amplitude (Avibr.) and transmembrane pressure (TMP), was investigated using a vibratory shear enhanced processing (VSEP) module with ultrafiltration (UF) and nanofiltration (NF) membranes. Components of the permeates, including chemical oxygen demand (COD), were measured, and membrane rejections were calculated to compare with threshold limit values. The results suggest that proper combination of Avibr. and TMP could mitigate membrane fouling. However, discontinuous module vibration resulted in more clogged membrane with lower fluxes, but slightly higher rejections. We conclude that investigating the significance of operational parameters is necessary for a wider, more energy and environment-friendly application in wastewater treatment.
Analysis of cold-formed steel rectangular hollow flange beams
Authors: Eid Nathalie , Joó Attila László 
Published: February 2021

AbstractThis paper presents the results of a theoretical-numerical study of laterally-restrained thin-walled steel rectangular hollow flange beams subjected to bending, shear and bending and shear interaction. Finite element analyses were carried out by using ANSYS software, and validated by previous experimental tests. Furthermore, the effect of intermediate stiffeners was investigated, where the improvement percentage in bending capacity was 4.4%. Additionally, all the corresponding outcomes were calculated according to EN 1993-1-3. The results showed that current standard rules tend to be somewhat conservative in both bending and bending and shear interaction cases, while they are not quite accurate in shear case.
Development of settlements and their knowledge centers
Authors: Paári Péter , Gyergyák János 
Published: February 2021

AbstractUniversity campuses and the surrounding urban environment are an integral part of each other's lives. The subject of this article is the relationship between them, primarily in relation to Pécs and University of Pécs. During the examinations, the network of connections regarding the city, university and its education sites will be visible. As it stands, the education sites of University of Pécs are not yet able to function as campuses. The creation of urban public spaces for the development of campuses is essential, as it can be seen through international examples and design. This may be the result of the numerous reductions and reorganization of educational sites.
Hardened properties and durability of large-scale 3D printed cement-based materials
Authors: Zhang Yu , Zhang Yunsheng , Yang Lin , Liu Guojian , Chen Yidong , Yu Shiwei , Du Hongjian 
Published: February 2021

AbstractThis study systematically investigates the hardened properties, durability and void distribution of large-scale 3D printed cement-based materials (3DPC). Experimental results indicate that 3DPC has higher compressive and flexural strengths, lower drying shrinkage, better resistance against sulfate attack and carbonation than mold-cast cement-based materials, but lower resistance to frost damage and chloride ion penetration. Computed tomography scanning reveals that voids in 3DPC are strongly oriented along the printing direction. Furthermore, the voids are much more inter-connected and even continuous among the printed filaments. This unique void distribution is the origin of anisotropy for 3DPC and can explain the determined directional dependency of mechanical strengths and durability performance. Along the printing direction, the more connected voids render more channels for gas and liquid to penetrate into 3DPC.