bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dentistry Website Analysis: An Overview of the Content of Formulated Questions and Answers
Authors: Bastani Peivand , Niknam Fatemeh , Rezazadeh Mahboobeh , Fedele Giampiero Rossi , Edirippulige Sisira , Samadbeik Mahnaz 
Published: July 2021

Abstract

Background: Analyzing the online medical questions and answer can be considered as a valuable tool for better comprehending mutual contractions between the patients and the caregivers in an online environment. Therefore, this study aimed to analyze the content of questions and answers posted on dentistry websites.Methods: A mixed-method study was conducted in 2020. A total of 1182 related questions and answers were included. The data was analyzed quantitatively according to the classification of the questions, main complaints of the subjects and length of the questions and answers using Excel2013. A qualitative content analysis was carried out also for data robustness and triangulation. Results: Of the 1354 questions, 866 of them were categorized into 38 categories according to the main sub-classes of the International Classification of Diseases to Dentistry and Stomatology. Furthermore, the inquiries were allocated to 3 communication styles to present the users` main complaints that included contextual (52.33%), emotional (6.79%) and focal (40.89%) strategies. Results of the qualitative content analysis have led to 6 main themes: seeking the related recommendations of any actions, treatment seeking, information seeking, seeking for causes and reasons, seeking for oral and dental health recommendations and seeking for the dentists’ diagnosis or comments.Conclusions: The present study can be used for designing specific customized websites of dentistry and help the website managers for better optimization of the websites. All these interventions can pave the way for developing teleconsulting in dentistry for middle-income countries.
Evaluation of Genetic Components and The Effect Of Non-Genetic Factors on Seminal Traits and Semen Rejection Rate in Murrah Buffalo Bulls Reared in Tropical Climatic Condition
Authors: P Ramajayan , Sivaselvam S.N. , Karthickeyan S.M.K. , Venkataramanan R. , Gopinathan A. , Poobitha S. 
Published: July 2021

Abstract
The present study was designed to determine the effect of genetic and non-genetic factors on semen production and semen discard patterns in Murrah buffalo bulls. Data on 54,268 ejaculates covering a period of 11 years were collected from 77 Murrah bulls maintained in the semen station. The effect of non-genetic factors on seminal parameters was analyzed using least-squares analysis of variance under general linear model. The repeatability estimates were computed by REML using WOMBAT program. Semen rejection rate among the main factors was evaluated using Chi-square test. The overall least-s quares means for semen volume, sperm concentration, total sperm per ejaculate, mass activity, initial motility, post-thaw motility, and frozen semen doses per ejaculate were 2.65 ml, 1222.04 million per ml, 3030.10 million, 2.64, 67.45%, 51.73%, and 128.80 doses. Similarly, repeatability estimates were 0.27, 0.25, 0.22, 0.28, 0.34, 0.27 and 0.23, respectively. The non-genetic factors, ejaculate number, period, season, and bull age, had a highly significant (P <0.01) effect on all the seminal traits. The bull-to-bull variation was also found to be significant (P <0.01). The phenotypic correlation coefficient between the traits was highly significant and positive for most traits. The semen rejection rate was high in pre-freezing (2.07%) than post-freezing (17.91%). Better seminal quality was observed in the first ejaculate, period V, south-west monsoon, and summer seasons. Bulls above eight years of age performed better than younger bulls, with best performance in bulls 12 years and above. The repeatability estimates were low to moderate, indicating a scope for selection based on moderate repeatable traits. This would be useful to the semen stations in tropical regions to frame suitable strategies to improve the quality and quantity of semen production.
Assembly Accuracy Prediction And Optimization of Aeroengine Rotor Under The Separation Condition Of Assembly And Measurement
Authors: Li Minghua , Wang Yunlong , Sun Qingchao , Mu Xiaokai 
Published: July 2021

Abstract
The measurement and assembly of aeroengine rotor are separated from each other, the uncertainty of the test position leads to the test data cannot reflect the geometric characteristics of the rotor itself, which makes it difficult to accurately measure and predict the assembly accuracy. Combined with the fact that the geometric characteristics of parts / components are not related to the measurement datum, an assembly accuracy test and prediction method is proposed to reduce the datum deviation and ensure the consistency of test data. Firstly, the small displacement torsor is used to describe the datum deviation, the inverse matrix transformation is applied to reduce the datum deviation, and the datum independent matrix is utilized to express the pose characteristics of the parts / components, which provides the data basis for the accurate prediction of assembly accuracy. Then, the pose transfer model based on the datum independent matrix is established, which is more comprehensive and clearer than the traditional accuracy prediction model. Furthermore, a direct optimization method is also established, which is more efficient than the traditional genetic algorithm. The assembly experiment of aeroengine rotor shows that the model and method proposed in this paper are beneficial to reduce the coaxiality of the front and rear fulcrum and they can better reflect the geometric characteristics of the rotor itself. The related research also has reference significance for other large-scale and high-precision mechanical product assembly.
Survival and Prognostic Factors of 40 Patients with Pulmonary Oligometastases Treated with Tomotherapy Hypofractionated Radiotherapy
Authors: Chen Rujun , Zhang Yajun , Li Mengmeng , Chen Xin , Sun Qian , Cai Feng , Xu Hongbo , Wan Qiangkun , Wang Gengming , Jiang Hao 
Published: July 2021

Abstract
Background: With continued improvement in radiotherapy technology, hypofractionated radiotherapy has helped achieve good results in the local control and toxicity of pulmonary oligometastases. This study aimed to investigate the efficacy of radiotherapy and the prognostic factors that affect survival in patients with pulmonary oligometastases who undergo helical tomotherapy (TOMO) hypofractionated radiotherapy.Methods: Ninety pulmonary oligometastases in 40 patients (26 males, 14 females; median age 57 years) were retrospectively investigated and treated with hypofractionated radiotherapy in the Department of Oncology and Radiotherapy of the First Affiliated Hospital of Bengbu Medical College during 2018-2020. Their Karnofsky performance status (KPS) was ≥70 points. The primary endpoints were overall survival (OS), local control (LC), and progression-free survival (PFS), and we determine the related influencing factors.Results: The median gross tumor volume (GTV) and planning target volume (PTV) were 9.7 cm³ (range 1.1–287.0 cm³) and 56.9 cm³ (range 16.3–494.2 cm³), respectively, the median biological effective dose, α/β=10 (BED10), was 76.8 Gy (range 56-96 Gy), and four-dimensional computed tomography positioning was applied to 52.5% of the patients. All patients completed the treatment plan during a median follow-up of 16.1 months (range 4.9–33.3 months). The 1- and 2-year OS rates were 90.3% and 55.2%, respectively. The 1- and 2-year LC rates were 80.8% and 64.7%, respectively. The 1- and 2-year PFS rates were 47.3% and 28.4%, respectively. Univariate analysis revealed that colorectal primary (p=0.004), age >57 years (p=0.037), and number of organ metastases ≥2 (p=0.046) were associated with OS, whereas disease-free interval (DFI) ≤17.4 months (p=0.032), number of lung metastases≥2 (p=0.049), and PTV >56.9 cm³ (p=0.041) were associated with LC; and number of metastatic organs ≥2 (p=0.015) was independently associated with PFS. In multivariate analysis, colorectal cancer (p=0.010) and age >57 years (p=0.009) were significantly associated with OS. No > grade 3 toxic reaction.Conclusions: The median OS, LC, and PFS rates of TOMO hypofractionated radiotherapy for pulmonary oligometastases were 24.9, 25.9, and 11.8 months, respectively, showing that good survival rates and low toxicity could still be achieved using the medium dose.
Rebuilding Hippocampus Neural Circuit with hADSC-derived Neuron Cells for Treating Ischemic Stroke
Authors: Wang Jian , Hao Rui , Guo Xuanxuan , Zhou Fei , Cao Limei , Gao Fengjuan , Wang Guangming , Ning Ke , Chen Xu , Huang Ying , Xu Jun , Gao Shane 
Published: July 2021

Abstract
BackgroundHuman adipose-derived stem cells (hADSCs) have been proven to be a promising autologous stem cell source for treating various neuronal diseases. Our study indicated that hADSCs could be induced into neuron-like cells in a stepwise manner that are characterized by the positive expression of MAP2, SYNAPSIN 1/2, NF-200, and vGLUT and electrophysiological activity. We first primed hADSCs into neuron-like cells (hADSC-NCs) and then intracerebrally transplanted them into MCAO reperfusion mice to further explore their in vivo survival, migration, integration, fate commitment and involvement in neural circuit rebuilding. ResultsThe hADSC-NCs survived well and transformed into MAP2-positive, Iba1- or GFAP-negative cells in vivo while maintaining some proliferative ability, indicated by positive Ki67 staining after 4 weeks. hADSC-NCs could migrate to almost every brain region, including the cortex, hippocampus, striatum, and hypothalamus, and further differentiate into mature neurons, as confirmed by action potential elicitation and postsynaptic currents. With the aid of a cell suicide system, hADSC-NCs were proven to have functionally integrated into the hippocampal memory circuit, where they contributed to spatial learning and memory rescue, as indicated by LTP improvement and subsequent GCV-induced relapse. In addition to infarction size shrinking and movement improvement, MCAO-reperfused mice showed positive immune modulation, including inhibition of the local proinflammatory factors IL-1α, IL-1β, IL-2, and MIP-1β and enhancement of the anti-inflammatory factors IL-15, IP-10, and MCP-1. ConclusionOverall, hADSC-NCs used as an intermediate autologous cell source for treating stroke can play multiple roles through cell replacement to rebuild neuronal circuits.
Forecasting and Controlling Key Performance Indicators in Call Centers
Authors: Mehrbod Negin , Cabral Izunildo , Requeijo José , Grilo Antonio 
Published: July 2021

Abstract
This paper proposes a methodology for modeling and controlling the performance of call centers. Most call centers use CRM (Customer Relationship Management) systems to record data of all contacts between agents and clients. These data may be autocorrelated. To model autocorrelated processes effectively, the proposed methodology integrates in a logical way ARIMA (Autoregressive Integrated Moving Average) modeling and SPC (Statistical Process Control) tools. ARIMA is used to model the process and identify the model that best fits the time series. The fitted model is used to compute residuals, predict future values for the quality variable(s) being monitored and determine the prediction errors. To achieve these goals, the Box-Jenkins methodology is employed. These outputs are then used to apply SPC, in this case the Shewhart control charts for autocorrelated data. First, the computed residuals are used to build the control charts in Phase I of SPC, verify the process stability and estimate the process parameters. Then, these parameters are used to establish the control limits of the charts used in Phase II of SPC to monitor and control the prediction errors. The proposed methodology is tested in a case study of a large call center in Portugal. The results of the case study suggest that ARIMA modeling and SPC, when properly integrated, provide a set of effective tools for monitoring call center performance when autocorrelated data are available. This paper has important implications for both theory and practice.
Attention Deficit in Children With Attention Deficit Hyperactivity Disorder at Primary School Age Measured With the Attention Network Test (Ant): A Protocol for a Systematic Review and Meta-analysis
Authors: Gradys Gabriela Oliwia , Lipowska Małgorzata , Bieleninik Łucja 
Published: July 2021

Abstract
BackgroundAttentional deficits are among the most bothersome symptoms in attention deficit hyperactivity disorder (ADHD). To date, the neurological basis of attentional deficits has not been fully described according to the diagnostic criteria. ADHD may result from deficits in various attributes of attention. There is no specialist neuropsychological diagnostic method that allows reliable distinction between primary attention disorders in the ethology of ADHD and secondary problems that may arise due to co-morbidities. This protocol aims to systematically review the literature to evaluate patterns of attention common to school-age children either diagnosed with ADHD or at high risk of ADHD, as measured by the neuropsychological attention network test (ANT). MethodsOur searchstrategy will consist of electronic databases (PubMed, PsychInfo, Web of Science, EMBASE, and Cochrane Library) and hand searching. Both prospective cohort studies and prospective studies of intervention effects will be included, provided they used the ANT. The primary output variable will be attention deficits. Screening and eligibility will be done independently by two reviewers based on pre-specified eligibility criteria. Data extraction will be based on a pre-pilot data extraction form, and conducted by two authors independently. Study quality will be assessed by two authors independently. Any discrepancies identified at any stage of the review will be resolved by discussion or/and consultation with another reviewer. We plan a descriptive summary of the findings and a meta-analysis if the data allow.DiscussionThe research will identify patterns of neuropsychological ANT results characteristic to both school-age children diagnosed with ADHD and those at high risk of having ADHD. Our results could be used to check whether the pattern of a child's performance in the ANT corresponds to the characteristic pattern of the results of children with ADHD. At present, the ANT is used only in research ; the results of this review will serve as a useful benchmark.Hopefully, in the future, it will be possible to use the ANT in the wider diagnosis of ADHD.Systematic review registrationPROSPERO: CRD42021249768
Bmis Have Different Effects on the Prevalence of OSA in Copd Patients: A Multicenter Cross-sectional Study
Authors: Xiong Mengqing , Zhao Zhiling , Nie Qingrong , Shi Zhihong , Wu Bin , Song Yan , He Xin , Wang Mengmei , Hu Ke 
Published: July 2021

Abstract
BackgroundObstructive sleep apnea (OSA) is prevalent in chronic obstructive pulmonary disease (COPD). Underweight and overweight have paradoxical effect on COPD prognosis, while obesity is a risk factor for OSA. We aimed to examine the association between BMIs and OSA risk in COPD patients. MethodsThis cross-section study included 1637 COPD subjects in the final analysis. BMI was classified into different groups. OSA was defined as varying severity by AHI. The associations between BMIs and risks of diverse severity of OSA were examined. ResultsFor varying severity of OSA, obesity associated with higher risk, while normal weight group associated with lower risk; overweight had no differences and underweight group had lower risk of moderate-to-severe OSA. Compared with normal weight, for OSA, the overweight group showed a trend of high risk whereas the underweight group indicated a higher risk (OR 1.424, 95% CI 1.015-1.988) (multivariable adjusted). BMI exhibited a J-shaped association with OSA; the risk for OSA was relatively flat at BMIs of 20-24 kg/m2 and above or below the risk increased (P for non-linearity 0.0057); for severe OSA, the plot depicted a S-shaped relation, the risk reached the lowest around 24 kg/m2 and then increased thereafter (P for non-linearity 0.0200). ConclusionsIn COPD population, for various severity of OSA, obesity is a firmly risk factor, overweight not influence the risk, while normal weight associate with lower risk; compared with normal weight, underweight increased the risk for OSA; BMI had a J-shaped association with OSA and a S-shaped with severe OSA.
Protocol for Scoping Review of Mediators of Women’s Care-seeking Behaviour During Infectious Disease Outbreaks in Sub-sahara Africa (SSA)
Authors: Ndu Mary Ntochukwu , Nouvet Elysee , Martin Janet , Yolanda Babenko-Mould 
Published: July 2021

Abstract
Globally, there continues to be a surge in infectious disease outbreaks. While old diseases are re-emerging, new ones are also emerging. This speed of emergence and re-emergence is accelerated by human development, changes in demographics, population, and the environment. We continue to see new patterns of disease infections from their natural hosts to humans, with pathogens now travelling beyond traditional vector areas and spreading to previously unaffected environments. Lessons from Ebola tell us that women and children will be disproportionately affected by infectious disease outbreaks. A mother’s health-seeking behaviour has direct implications for the health of her children and the entire family. The way women reach health decisions could be the deciding factor in whether they or their children live. The broad objective of this review of the literature is to explore, identify, and map gaps in the literature on factors resulting from infectious diseases outbreak that could impact women’s health care decision-making. The review will compare health-seeking behaviour in sub-Sahara Africa during outbreak and non-outbreak periods, to generate a comparative analysis of the health behaviour of women of reproductive age and factors impacting on their health-seeking behaviour when there is an outbreak versus no outbreak. It is anticipated to be of interest to sub-Saharan Africa governments, national and international policymakers, and researchers, seeking to expand their attention to mothers and their children’s needs in emergency preparedness.
A BL Lacertae object at a cosmic age of 800 Myr
Authors: Koptelova Ekaterina , Hwang Chorng-Yuan 
Published: July 2021

Abstract
BL Lacertae objects (BL Lacs) and flat-spectrum radio quasars
(FSRQs), known as blazars, are low- and high-luminosity radio-loud Active Galactic Nuclei (AGNs) with relativistic jets pointed towards Earth (1). Evolving from
FSRQs (2,3), BL Lac objects host ~109 Msun supermassive black holes (SMBHs, where Msun is the mass of the Sun) and reside preferentially in giant elliptical galaxies of stellar masses 1011-1012Msun (4-7). The known BL Lacs are relatively nearby objects found below
redshift 3.6 (3,8,9). Here, we report the discovery of a BL Lac object, FIRST J233153.20+112952.11 (hereafter J2331+11), at a redshift of 6.57 corresponding to an age of the Universe of ~800 Myr. As the typical BL Lac, J2331+11 is a compact radio source with the flat power-law radio continuum, no emission lines in its near-infrared spectrum, and significant variability. The optical-to-radio continuum of J2331+11 is entirely dominated by the synchrotron emission of a relativistic jet. J2331+11 provides
evidence for the shorter formation timescale of massive SMBHs with jets and bulge-dominated galaxies than that expected from the Eddington-limited growth of SMBHs and hierarchical galaxy formation. The rapid formation of BL Lacs at early cosmic epochs should have taken place in the densest regions of the early Universe.
Which Incision is Better for Orthotopic Rat Liver Transplantation, Transverse or Midline?
Authors: Tang Gaofeng , Zou Zhongwu , Zhao Huibo , Wang Weiwei , Chen Guoyong , Zhou Shaotang 
Published: July 2021

Abstract
Orthotopic rat liver transplantation (OLT) is a complex procedure extensively applicable to basic science, myriad complications can occur, incision-related self-biting has not been reported after liver transplantation. For the project of tolerance induction through stem cells, OLT was performed from inbred Sprague Dawley (SD) rat to SD (control group, n = 9), SD to Lewis (chronic rejection, n = 11), and OLT from Lewis allograft to Brown Norway (BN) rats (acute rejection, n = 63), the acute rejection group was sub-grouped into the transverse incision group(n = 26) and midline group(n = 37), Cyclosporine A was injected at 2mg/kg into the rejection groups once daily for 14 days, lidocaine cream alone or with naloxone was used for pain-relieving. The recipient survival and wound status were the primary endpoint of this study. For SD→SD, 30-day survival rate was 88.9%, no self-biting behavior occurred; for SD→Lewis, 30-day survival rate was 54.5%, the degree II of self-biting occurred in 2 cases. For Lewis→BN with transverse incision, 30-day survival rate was 51.8%, severe self-biting occurred in 16 cases in 8–27 days and 5 more cases over 30 days, which caused death or euthanasia, the degree 2 of biting occurred in 2 cases. For Lewis→BN with midline incision, 30-day survival rate was 86.0%, no severe self-biting occurred, mild self-biting in 2 cases. There was difference in the biting–related survival between two sub-groups (p = 0.003). In conclusion, incision-related self-biting behavior is species-specific for rats, the transverse incision is the pain-causing reason; the midline one is effective to avert occurrences.
Circulating T Cell Profiling of Lymphedema Reveals Upregulated Immune Checkpoint Molecules and Preserved Stem Cell-Like Memory T Cells
Authors: Imai Hirofumi , Kawase Takakazu , Mese Toshiro , Roh Solji , Yoshida Shuhei , Fujita Asuka , Uchiki Toshio , Sasaki Ayano , Nagamatsu Shogo , Takazawa Atsushi , Ichinohe Tatsuo , Koshima Isao 
Published: July 2021

Abstract
Lymphedema is a common complication seen in patients with cancer who undergo lymph node dissection. Lymphedema is a debilitating progressive condition that severely restricts the quality of life owing to the accompanying cellulitis and angiosarcoma, which suggest that immune dysfunction is associated with lymphedema. However, the immune status of peripheral T cells during lymphedema remains poorly understood. Using the peripheral blood T cells of patients with lymphedema and age-matched healthy controls (HC), we compared the profile of various functional T cell subsets in this study. Expression of PD-1, Tim-3, and Lag-3 increased in peripheral CD4 + but not CD8 + T cell populations, and the proportion of regulatory T cells was higher in lymphedema patients than in HC. The proportions of naïve CD4 + and CD8 + T cells were lower in lymphedema patients than in HC, although proportions of stem cell-like memory T cell subsets were constant. These observations suggest the distinct immunosuppressive status of patients with lymphedema, which might be related to the development of the accompanying cellulitis and angiosarcoma. This study might provide new insights into the late complication after undergoing lymph node dissection as a cancer treatment.