bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intonation Attributes of Traditional Singing And Recitations of Suzhou Musical Drama
Authors: Sitsui Zhang 
Published: May 2021

The aim of this paper is to identify the intonation attributes of traditional singing and recitation in Suzhou musical drama, which is embodied in the melodic organization of melody, rhythmic pattern, signs of syncretism with speech and gestures of singers-actors, which add semantic certainty and artistic expression to images.
Research methodology. The study investigates this issue by examining the basic methods and principles of musicology.
Results. Suzhou drama is based on traditional folk songs of the northern regions of Jiangsu province, “labor cries”, such as urging bulls when ploughing, woman crying, jumping on horses etc. The melody of the Lahongqiang is characterized by the transitions of the female falsetto into high octaves, which are balanced by the inclusion of a recitative that affects the feelings of the listener.
The realization of works of Suzhou musical drama, in particular vocal-declamatory methods of performance, requires singers-actors to master the skills of improvisation in the process of creating a stage action. The intonation attributes of melody and declamatory speech, which are based on dialects of oral language, folk songs of the northern regions of Jiangsu province, due to the traditions of the population of this area. The fricative basis of singing is pentatonic, the structure of the “jumping” rhythm with frequent “turns” evokes in the listener a sense of novelty, energetic free movement. The properties of the declamatory pattern of “da-shetou” is one of the outstanding features of Suzhou musical drama.
Novelty: the concept of “Lahongqiang” can be used in a number of meanings: in a broad sense — if we talk about the traditional nature of one of the types of songwriting; in the narrow sense — to use as the name of the music genre and performing arts.
Practical significance. The properties of the declamatory pattern of “da-shetou” is one of the outstanding features of Suzhou musical drama. Importantly, it enriches the area of cognitive ability to understand the communicative “axis” of the East-West artistic relationship.
Technical and operative factors affecting magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor: experience from 250 treatments
Authors: Kim Myung Ji , Park So Hee , Chang Kyung Won , Kim Yuhee , Gao Jing , Kovalevsky Maya , Rachmilevitch Itay , Zadicario Eyal , Chang Won Seok , Jung Hyun Ho , Chang Jin Woo 
Published: May 2021

OBJECTIVE
Magnetic resonance imaging–guided focused ultrasound (MRgFUS) provides real-time monitoring of patients to assess tremor control and document any adverse effects. MRgFUS of the ventral intermediate nucleus (VIM) of the thalamus has become an effective treatment option for medically intractable essential tremor (ET). The aim of this study was to analyze the correlations of clinical and technical parameters with 12-month outcomes after unilateral MRgFUS thalamotomy for ET to help guide future clinical treatments.

METHODS
From October 2013 to January 2019, data on unilateral MRgFUS thalamotomy from the original pivotal study and continued-access studies from three different geographic regions were collected. Authors of the present study retrospectively reviewed those data and evaluated the efficacy of the procedure on the basis of improvement in the Clinical Rating Scale for Tremor (CRST) subscore at 1 year posttreatment. Safety was based on the rates of moderate and severe thalamotomy-related adverse events. Treatment outcomes in relation to various patient- and sonication-related parameters were analyzed in a large cohort of patients with ET.

RESULTS
In total, 250 patients were included in the present analysis. Improvement was sustained throughout the 12-month follow-up period, and 184 (73.6%) of 250 patients had minimal or no disability due to tremor (CRST subscore < 10) at the 12-month follow-up. Younger age and higher focal temperature (Tmax) correlated with tremor improvement in the multivariate analysis (OR 0.948, p = 0.013; OR 1.188, p = 0.025; respectively). However, no single statistically significant factor correlated with Tmax in the multivariate analysis. The cutoff value of Tmax in predicting a CRST subscore < 10 was 55.8°C. Skull density ratio (SDR) was positively correlated with heating efficiency (β = 0.005, p < 0.001), but no significant relationship with tremor improvement was observed. In the low-temperature group, 1–3 repetitions to the right target with 52°C ≤ Tmax ≤ 54°C was sufficient to generate sustained tremor suppression within the investigated follow-up period. The high-temperature group had a higher rate of balance disturbances than the low-temperature group (p = 0.04).

CONCLUSIONS
The authors analyzed the data of 250 patients with the aim of improving practices for patient screening and determining treatment endpoints. These results may improve the safety, efficacy, and efficiency of MRgFUS thalamotomy for ET.
The Kempe incision for decompressive craniectomy, craniotomy, and cranioplasty in traumatic brain injury and stroke
Authors: Abecassis Isaac Josh , Young Christopher C. , Caldwell David J. , Feroze Abdullah H. , Williams John R. , Meyer R. Michael , Kellogg Ryan T. , Bonow Robert H. , Chesnut Randall M. 
Published: May 2021

OBJECTIVE
Decompressive craniectomy (DC) is an effective, lifesaving option for reducing intracranial pressure (ICP) in traumatic brain injury (TBI), stroke, and other pathologies with elevated ICP. Most DCs are performed via a standard trauma flap shaped like a reverse question mark (RQM), which requires sacrificing the occipital and posterior auricular arteries and can be complicated by wound dehiscence and infections. The Ludwig Kempe hemispherectomy incision (Kempe) entails a T-shaped incision, one limb from the midline behind the hairline to the inion and the other limb from the root of the zygoma to the coronal suture. The authors’ objective in this study was to define their implementation of the Kempe incision for DC and craniotomy, report clinical outcomes, and quantify the volume of bone removed compared with the RQM incision.

METHODS
A retrospective review of a single-surgeon experience with DC in TBI and stroke was performed. Patient demographics, imaging, and outcomes were collected for all DCs from 2015 to 2020, and the incisions were categorized as either Kempe or RQM. Preoperative and postoperative CT scans were obtained and processed using a combination of automatic segmentation (in Python and SimpleITK) with manual cleanup and further subselection in ITK-SNAP. The volume of bone removed was quantified, and the primary outcome was percentage of hemicranium removed. Postoperative surgical wound infections, estimated blood loss (EBL), and length of surgery were compared between the two groups as secondary outcomes. Cranioplasty data were collected.

RESULTS
One hundred thirty-six patients were included in the analysis; there were 57 patients in the craniotomy group (44 patients with RQM incisions and 13 with Kempe incisions) and 79 in the craniectomy group (41 patients with RQM incisions and 38 Kempe incisions). The mean follow-up for the entire cohort was 251 ± 368 days. There was a difference in the amount of decompression between approaches in multivariate modeling (39% ± 11% of the hemicranium was removed via the Kempe incision vs 34% ± 10% via the RQM incision, p = 0.047), although this did not achieve significance in multivariate modeling. Wound infection rates, EBL, and length of surgery were comparable between the two incision types. No wound infections in either cohort were due to wound dehiscence. Cranioplasty outcomes were comparable between the two incision types.

CONCLUSIONS
The Kempe incision for craniectomy or craniotomy is a safe, feasible, and effective alternative to the RQM. The authors advocate the Kempe incision in cases in which contralateral operative pathology or subsequent craniofacial/skull base repair is anticipated.
ПАМ’ЯТЬ ЯК АРХІВ ПРЕЦЕДЕНТНИХ СМИСЛІВ У ПРОЦЕСІ МУЗИЧНО-ВИКОНАВСЬКОЇ ІНТЕРПРЕТАЦІЇ (НА ПРИКЛАДІ ЧЕТВЕРТОГО КОНЦЕРТУ Л. БЕТХОВЕНА ТА ДО 250-РІЧЧЯ ВІД ДНЯ НАРОДЖЕННЯ КОМПОЗИТОРА)
Authors: Sapsovych Oleksandra Arkadiivna 
Published: May 2021

Мета дослідження – простежити взаємодію процесів архівації в пам’яті «прецедентних смислів» і створення музично-виконавської ін- терпретації на прикладі практичного досвіду музиканта-виконавця. Методологія дослідження полягає в історичному екскурсі, репрезента- ції і структуруванні досвіду вибудовування і проживання алгоритму на- родження власного прочитання музичного тексту. Наукова новизна до- слідження: показаний емпіричний, предметний шлях архівації (а також розархівації, релевантної осмисленню) прецедентних смислів музиканта з подальшим їх використанням. Викладено і апробовано практичний алгоритм переходу з ролі виконавця до ролі інтерпретатора музичного тексту. Висновки. Прецедентні смисли музиканта ми визначаємо як усві- домлену похідну емоційної пам’яті. Емоційна пам’ять – скарбничка пе- режитих емоцій, є основою прецедентних смислів, самі ж прецедентні смисли – це відрефлексовані й осмислені емоції (осмислені як у причинах, так і в подальшому їх застосуванні у творчості). Отже, розуміємо їх як такі, що виникають не тільки асоціативно, але і свідомо. Системоутворюючими елементами концепції народження самобут- ньої інтерпретації музичного тексту на базі феномена прецедентних смислів є: – сприйняття та збереження. Народження особистого художньо- го прочитання-осмислення виконуваної музики починається з запуску акумулятивного процесу: сприйняття і архівації (збереження в пам’я- ті) якомога більшого числа прецедентів (фактів) особистого зіткнення з будь-якими потенційно цінними джерелами інформації і емоційного досвіду; – пошук, осмислення і зіставлення. Пошук здійснюється на основі акумульованого досвіду зіткнення з носіями інформації, за допомогою розархівації прецедентних смислів, що архівувалися раніше в пам’яті індивідуума. Осмислення відбувається в процесі пошуку і спровоковано ним. Зіставлення виступає як додатковий інструментарій переробки отриманих знань; – народження творчого похідного прецедентних смислів, що виникає внаслідок реалізації вищеперелічених елементів і виступає підґрунтям створення самобутньої інтерпретації.
PENGARUH MODEL PEMBELAJARAN POE TERHADAP KEMAMPUAN PEMAHAMAN KONSEP IPA SISWA SD
Authors: Novanto Yogi Setya , Anitra Rien , Wulandari Fajar 
Published: May 2021

ABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh penggunaan model pembelajaran POE (Predict, Observe, Explain) terhadap kemampuan pemahaman konsep IPA siswa pada materi panas dan perpindahannya. Penelitian ini dilaksanakan di MIS Ushuluddin Singkawang. Jenis penelitian yang digunakan yaitu penelitian kuantitatif dengan metode quasi experimental design, dengan bentuk desain post-test only control design. Populasi dalam penelitian ini adalah seluruh siswa kelas V MIS Ushuluddin Singkawang. Sampel diambil menggunakan teknik purposive sampling. Setelah pengambilan sampel, yang terpilih menjadi kelas eksperimen adalah kelas VA dengan menggunakan model pembelajaran POE dan VB sebagai kelas kontrol yang menggunakan model pembelajaran langsung. Hasil penelitian menunjukkan bahwa: (1) Terdapat pengaruh kemampuan pemahaman konsep IPA siswa antara kelas yang diberikan model pembelajaran POE dengan kelas yang diberikan pembelajaran langsung pada materi panas dan perpindahannya di kelas V MIS Ushuluddin Singkawang; (2) Terdapat perbedaan kemampuan pemahaman konsep IPA siswa antara kelas yang diberikan model pembelajaran POE dengan kelas yang di berikan model pembelajaran langsung pada materi panas dan perpindahannya di kelas V MIS Ushuluddin Singkawang. Kata kunci: model pembelajaran POE; kemampuan pemahaman konsep. ABSTRACTThis study is aimed at learning the influence of the use of the POE learning model (Predict, Observe, Explain) on a student's ability to understand science concepts on hot matter and transmigration. The study is carried out at MIS Ushuluddin Singkawang. The kind of research used was quantitative research with experimental quasi design. With a design post-test only design control. The population in the study are all the students in the V MIS Ushuluddin Singkawang class. The sample was taken using an additive sampling, after taking the selected sample into a VA class experiment which was an experimental class using the POE and VB control class that use a direct learning model. Research concluded that: (1) there is an influence on a student's ability to understand natural science between a class given by the POE learning model and a class given direct learning on hot matter and transfer to V MIS Ushuluddin Singkawang class; (2) there is a difference in the ability to understand a student science concept between the class given by the POE learning model and the class provided the direct learning model for hot matter and transfer to V MIS Ushuluddin Singkawang class. Keywords: POE learning models; the ability to understand concepts.
Development of innovations in Sweden HEIs: a case study of Uppsala University
Authors: Zymina Svitlana 
Published: May 2021

The article emphasizes that in the context of accelerated democratization and European integration, the use of a value model of the management in higher education, based on the university autonomy and their public («third») mission, is urgent for the HEIs of Ukraine. Creating innovations is its integral part.
Sweden experience, as a country with a high innovation index, regarding the development of innovation in higher education institutions is analyzed. The country's policy on the organization of research at universities, aimed at strengthening the «strategic» research areas, such as interdisciplinary industrial and social research, is considered. The main initiatives of the country's government, which have helped to strengthen the strategic fields of research activity and stimulate the emergence of new values in the higher education sector, such as entrepreneurship and competitiveness, are given. In the case study a successful example of Uppsala University infrastructure was studied using the HEInnovate method and the following key criteria - governance, potential of HEI/ financing/personnel/initiatives, entrepreneurial education, innovation support, knowledge sharing and collaboration, Internationalization, digital transformation. The main values and cultural guidelines of the institution, its governance at different levels and communication between different stakeholders and university are characterized. The main productive initiatives of the university, aimed at developing the skills and competencies of researchers and students, necessary for the successful implementation of projects, commercialization, and start-ups are considered. A number of factors that have had a positive impact on the innovation potential of Swedish universities as well as on the country's position in global innovation rankings have been identified. It is suggested to use the experience in dealing with innovators and external stakeholders of Uppsala University by Ukrainian research universities for upgrading their infrastructure.
RRY Inhibits Amyloid-β1–42 Peptide Aggregation and Neurotoxicity
Authors: Sun Xicui , Duan Songwei , Cao Anna , Villagomez Bryan , Lin Runxuan , Chen Hongxia , Pi Liya , Ren Bin , Chen Rong , Chen Minjie , Ying Zhekang , Fang Shenyun , Cao Qi 
Published: May 2021

Background: Current understanding of amyloid-β protein (Aβ) aggregation and toxicity provides an extensive list of drugs for treating Alzheimer’s disease (AD); however, one of the most promising strategies for its treatment has been tri-peptides. Objective: The aim of this study is to examine those tri-peptides, such as Arg-Arg-Try (RRY), which have the potential of Aβ1–42 aggregating inhibition and Aβ clearance. Methods: In the present study, in silico, in vitro, and in vivo studies were integrated for screening tri-peptides binding to Aβ, then evaluating its inhibition of aggregation of Aβ, and finally its rescuing cognitive deficit. Results: In the in silico simulations, molecular docking and molecular dynamics determined that seven top-ranking tri-peptides could bind to Aβ1–42 and form stable complexes. Circular dichroism, ThT assay, and transmission electron microscope indicated the seven tri-peptides might inhibit the aggregation of Aβ1–42 in vitro. In the in vivo studies, Morris water maze, ELISA, and Diolistic staining were used, and data showed that RRY was capable of rescuing the Aβ1–42-induced cognitive deficit, reducing the Aβ1–42 load and increasing the dendritic spines in the transgenic mouse model. Conclusion: Such converging outcomes from three consecutive studies lead us to conclude that RRY is a preferred inhibitor of Aβ1–42 aggregation and treatment for Aβ-induced cognitive deficit.
Effects of Cell Confluence on the Immunological and Migration Receptors of Wharton Jelly’s Mesenchymal Stem Cells
Authors: Voisin Charlotte , Cauchois Ghislaine , Bensoussan Danièle , Huselstein Céline 
Published: May 2021

Mesenchymal stem/stromal cells (MSCs) are a promising tool for cell-based therapy thanks to their ability to secrete trophic factors and immunomodulatory potential. So far, these cells are used to treat a variety of inflammatory diseases like sepsis or severe graft-versus-host disease (GvHD). Considering the number of cells required for their use in cell therapy (between 1–3 × 106 cells/kg), a primary expansion is necessary. However, after an intravenous injection, few cells are found in tissue lesion or in bone marrow. One hypothesis is that chemotactic signals that guide MSCs to an appropriate environment would be altered during in vitro expansion. It is therefore essential to define better conditions of expansion, particularly with good manufacturing process, to obtain enough MSCs, while preserving their immunomodulatory properties and expression of migration molecules. The aim of this research project is to investigate the effect of cell confluence on migration potential and immunological properties of Wharton’s jelly (WJ) MSCs. This research is investigated with 3 levels confluency, at 50, 80 and 100% of confluence by using good manufacturing practice (GMP). We found a better expression of immunomodulatory molecules (PD-L1) and migratory molecules (CD44, membrane CXCR7) for cells that reached 50% confluence. Furthermore, co-stimulatory molecules appear to be less expressed when MSCs are at low confluency. In conclusion low confluence culture should be privileged to improve immunomodulatory and migration phenotype.
Identification and Quantification of Malignant Cells in Cerebrospinal Fluid
Authors: Faure Gilbert , Le Rhun Emilie , Tu Qien , Kohler Chantal , Taillandier Luc , Cai Huili , Wu Xianglei , De Carvalho Marcelo 
Published: May 2021

Usual diagnostic methods of leptomeningeal metastases (LM) in CerebroSpinal fluid (CSF), lack both specificity and sensitivity. The Veridex CellSearch® technique quantifying circulating tumour cells (CTCs) in blood was adapted to detect Tumour Cells (CSFTCs) in CSF from cancer patients with LM. CSF samples from 60 patients with established or suspected breast cancer or lung cancer LM and/or melanoma were evaluated. 5 mL CSF samples were collected on CellSave® preservative and analyzed within 3 days after CSF sampling. Gold Standard cytological analysis on 1 to 10 mL CSF samples from patients with established LM allowed sometimes the detection but usually not the quantification of TCs. In established LM, EpCAM+/cytokeratin+ or CD146+/HMW-MAA+ nucleated (DAPI+) cells were observed and enumerated with precision from one to up to 10 000 cells/mL. Their morphology on digital images galleries could be discriminant between breast and lung cancer. This methodology, established on a limited volume of CSF compared to the Gold Standard and allowing delayed processing, is of great interest in the diagnosis and follow-up of cancer patients with LM. The reliability of the method also opens new fields of investigation for other biological fluids and to precise the stem cell potential of metastatic cells in CSF.
Streblus asper Lour. exerts MAPK and SKN-1 mediated anti-aging, anti-photoaging activities and imparts neuroprotection by ameliorating Aβ in Caenorhabditis elegans
Authors: Prasanth Mani Iyer , Brimson James Michael , Sheeja Malar Dicson , Prasansuklab Anchalee , Tencomnao Tewin 
Published: May 2021

BACKGROUND: Streblus asper Lour., has been reported to have anti-aging and neuroprotective efficacies in vitro. OBJECTIVE: To analyze the anti-aging, anti-photoaging and neuroprotective efficacies of S. asper in Caenorhabditis elegans. METHODS: C. elegans (wild type and gene specific mutants) were treated with S. asper extract and analyzed for lifespan and other health benefits through physiological assays, fluorescence microscopy, qPCR and Western blot. RESULTS: The plant extract was found to increase the lifespan, reduce the accumulation of lipofuscin and modulate the expression of candidate genes. It could extend the lifespan of both daf-16 and daf-2 mutants whereas the pmk-1 mutant showed no effect. The activation of skn-1 was observed in skn-1::GFP transgenic strain and in qPCR expression. Further, the extract can extend the lifespan of UV-A exposed nematodes along with reducing ROS levels. Additionally, the extract also extends lifespan and reduces paralysis in Aβ transgenic strain, apart from reducing Aβ expression. CONCLUSIONS: S. asper was able to extend the lifespan and healthspan of C. elegans which was independent of DAF-16 pathway but dependent on SKN-1 and MAPK which could play a vital role in eliciting the anti-aging, anti-photoaging and neuroprotective effects, as the extract could impart oxidative stress resistance and neuroprotection.
ASPECTS OF BIM-MANAGER TRAINING
Authors: Levchenko Oleksii , Mykhailenko Andrii 
Published: May 2021

The article demonstrates the timeliness of the emergence in Ukraine of new positions for higher / intermediate BIM qualification specialists at modern architectural offices and construction companies during design, construction, and operational stages of an architectural object. Attention is focused on the legislative framework for the development of interrelated (architectural and construction) specialties in Ukraine. At the same time, a shortage of personnel with deep knowledge of BIM technologies is noted.
Development of specialized courses and curricula for training and integration of professional BIM managers in the design and development business throughout the country is encouraged. The hierarchy of the main responsibilities and functions of BIM managers determines the list of tasks and the direction of their professional activities. Engaging specialists from real design, leading specialized institutions, educational and experimental centers for the formation of an in-depth specialized training course for top-level specialists is proposed. For the preparation of BIM managers, the concept of a training program for senior years of a specialized university, a refresher courses or other postgraduate trainings in licensed training centers has been proposed. It includes training in project administration, setting up collaboration, an interdisciplinary system, checking the model’s quality, effective organization of BIM processes themselves and within a company, as a whole. A system of organizational, technical, methodological, software and other means of ensuring the educational process is considered. The stages and specifics of professional staff development, as well as preparation for the subsequent BIM certification, have been specified.