bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Security Parameters and Network Infrastructure on Cloud
Authors: Praveen Kumar S. , Jaya T. 
Published: March 2021

Abstract
This paper pertains to an analytical approach towards establishing standards for network performance on the cloud. Cloud being the most promising domain, is yet hindered by the lack of standardization. To resolve this issue we propose a methodology suitable for all essential protocols in contrasting network architectures. In extension to this, security breaches also severe the threat to cloud data and its privacy. To bridge the two imperative aspects of a cloud service, we intend to deploy a deep learning classification model on Google collab, acting as an interface between the cloud database and client-server. Essential parameters including throughput(X), average delay(ζ), loss function(l) and accuracy. We extend to present our results as the optimized cloud standards.
An Intuitive Remote Monitoring Framework for Water Quality in Fish Pond using Cloud Computing
Authors: Sivakumar S. , Ramya V. 
Published: March 2021

Abstract
Accuracy in prediction of water quality is a recent research domain gaining popularity in smart aquaculture. In aquaculture, the modifications in water quality parameters possess nonlinearity, dynamicity, unstableness and complexity due to the open environment with its surroundings. Conventional prediction methods have several disadvantages like poor generalization, lower accuracy and high time complexity. By considering these issues, a Novel water quality prediction method interfaced with (IoT)Internet of Things termed as Low-Cost Real-Time Monitoring System (LCRTMS) is proposed to predict water temperature, pH, DO, and Ammonia. Multi-sensors and Blynk private cloud integrated framework are used for collecting data in real-time and enhancing the remote monitoring capabilities. Experimental results indicate that the accuracy in predicting temperature, DO, pH and ammonia can attain 98.56% in 0.257 seconds and 98.97% in 0.301seconds in the short-term prediction.
Soft morphological filtering using hypergraphs
Authors: Unnikrishnan Nuja M , Tom Mini , Bino Sebastian V , Thomas K V 
Published: March 2021

Abstract
A new framework of soft mathematical morphology on hypergraph spaces is studied. Application in image processing for filtering objects defined in hypergraph spaces are illustrated using several soft morphological operators-openings, closings, granulometries and ASF acting (a) on the subset of vertex and hyperedge set of a hypergraph and (b) on the subhypergraphs of a hypergraph. Experimental results dealing with the extension of soft morphological operators to gray scale images are presented in this paper. The results obtained are promising and is a better substitute for the prevailing methods.
Electrocatalytic property of nitrogen-doped graphite-supported CeO2-CoOx
Authors: Ge Ben , Yue Tonglian , Liu Jinmei , Wu Xu , Chen Bo , Li Yongkang , Yang Zhibin 
Published: March 2021

Abstract
Ceria has been widely used as a catalyst in photocatalysis, automobile exhaust purification, and organic degradation. However, ceria has poor intrinsic catalytic performance and usually requires modifications. In this study, N-doped graphite was used as a substrate, and then CeO2-CoOx was attached to N-doped graphite. Afterward, the effects of the recombination with N-doped graphite and those of Co doping on the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) catalytic ability of CeO2 were studied. The experimental results showed that the electrocatalytic performance of CeO2-CoOx/N-rGO is higher than that of pure CeO2 and CeO2/N-rGO. After the N-doped graphite recombination, the number of transferred electrons increased at high potential, which fully illustrates that graphite can effectively reduce the overpotential of ORR. The 0.56 eV shift of the C1s in CeO2-CoOx/N-rGO to high binding energy revealed that CeO2-CoOx and N-rGO were combined with each other through covalent bonds. In addition, the increased pyridine nitrogen of N-rGO after the recombination improved the electrocatalytic performance of CeO2-CoOx/N-rGO. Overall, the catalytic ability of CeO2 was greatly improved, and the modified CeO2-CoOx/N-rGO composite showed better catalytic performance for the ORR and OER compared with Pt/C and RuO2.
Aesthetic Self-Forgetfulness
Authors: Mäcklin Harri 
Published: March 2021

Abstract
Intense aesthetic experiences are often described in terms of self-forgetfulness, where the perceiver becomes immersed in the aesthetic phenomenon to the extent of losing consciousness of being the subject of the experience. Although such experiences have been described from the early eighteenth century onwards, there is still a surprising lack of detailed investigation on the precise nature of aesthetic self-forgetfulness. What happens in this experience, and precisely what is the ‘self’ that is forgotten? Building on phenomenological theories of self-consciousness, I argue that aesthetic self-forgetfulness cannot be understood as an absolute eradication of the self, as a pre-reflective self-consciousness stays intact even in deeply immersive aesthetic experiences. Thus, I argue that talk of self-forgetfulness is to some extent misleading, and the changes in the subject’s self-relation during aesthetic experience is better understood in terms of an altered sense of agency.
TIPS: trajectory inference of pathway significance through pseudotime comparison for functional assessment of single-cell RNAseq data
Authors: Zheng Zihan , Qiu Xin , Wu Haiyang , Chang Ling , Tang Xiangyu , Zou Liyun , Li Jingyi , Wu Yuzhang , Zhou Jianzhi , Jiang Shan , Wan Ying , Ni Qingshan 
Published: March 2021

Abstract
Recent advances in bioinformatics analyses have led to the development of novel tools enabling the capture and trajectory mapping of single-cell RNA sequencing (scRNAseq) data. However, there is a lack of methods to assess the contributions of biological pathways and transcription factors to an overall developmental trajectory mapped from scRNAseq data. In this manuscript, we present a simplified approach for trajectory inference of pathway significance (TIPS) that leverages existing knowledgebases of functional pathways and other gene lists to provide further mechanistic insights into a biological process. TIPS identifies key pathways which contribute to a process of interest, as well as the individual genes that best reflect these changes. TIPS also provides insight into the relative timing of pathway changes, as well as a suite of visualizations to enable simplified data interpretation of scRNAseq libraries generated using a wide range of techniques. The TIPS package can be run through either a web server or downloaded as a user-friendly GUI run in R, and may serve as a useful tool to help biologists perform deeper functional analyses and visualization of their single-cell data.
Drug repurposing against breast cancer by integrating drug-exposure expression profiles and drug–drug links based on graph neural network
Authors: Cui Chen , Ding Xiaoyu , Wang Dingyan , Chen Lifan , Xiao Fu , Xu Tingyang , Zheng Mingyue , Luo Xiaomin , Jiang Hualiang , Chen Kaixian 
Published: March 2021

Abstract

Motivation
Breast cancer is one of the leading causes of cancer deaths among women worldwide. It is necessary to develop new breast cancer drugs because of the shortcomings of existing therapies. The traditional discovery process is time-consuming and expensive. Repositioning of clinically approved drugs has emerged as a novel approach for breast cancer therapy. However, serendipitous or experiential repurposing cannot be used as a routine method.

Results
In this study, we proposed a graph neural network model GraphRepur based on GraphSAGE for drug repurposing against breast cancer. GraphRepur integrated two major classes of computational methods, drug network-based and drug signature-based. The differentially expressed genes of disease, drug-exposure gene expression data and the drug–drug links information were collected. By extracting the drug signatures and topological structure information contained in the drug relationships, GraphRepur can predict new drugs for breast cancer, outperforming previous state-of-the-art approaches and some classic machine learning methods. The high-ranked drugs have indeed been reported as new uses for breast cancer treatment recently.

Availabilityand implementation
The source code of our model and datasets are available at: https://github.com/cckamy/GraphRepur and https://figshare.com/articles/software/GraphRepur_Breast_Cancer_Drug_Repurposing/14220050.

Supplementary information
Supplementary data are available at Bioinformatics online.
Phylogeography of Otaria flavescens (Carnivora: Pinnipedia): unravelling genetic connectivity at the southernmost limit of its distribution
Authors: Peralta Diego M , Cappozzo Humberto L , Ibañez Ezequiel A , Lucero Sergio , Failla Mauricio , Túnez Juan I 
Published: March 2021

Abstract
The Pleistocene glacial period shaped the current genetic structure of numerous species. The last glacial dynamics has been proposed to have split the South American sea lion, Otaria flavescens, into two Evolutionarily Significant Units (ESUs), one on each side of the continent. However, previous studies have not provided genetic information on colonies found along 3000 km of coastline of the southernmost limit of the species distribution, where gene flow could occur. We conducted an exhaustive phylogeographical analysis of O. flavescens using a mtDNA marker, including, for the first time, data from colonies living south of latitude 45° S, in the Argentinian provinces of Santa Cruz and Tierra del Fuego. Our results indicated the presence of five Conservation Units across the distribution range of O. flavescens and suggest that the Patagonian population must have expanded about 150 000 BP. We found evidence for gene flow across the entire species range, supporting a scenario of secondary contact in Tierra del Fuego where representatives of the oldest lineages coexist. The presence of gene flow between oceans leads us to reject the assumption of complete reciprocal monophyly for mtDNA between the presumed ESUs, suggesting that the species constitutes a single Evolutionarily Significant Unit.
The School Career of Children With Hearing Loss in Different Primary Educational Settings—A Large Longitudinal Nationwide Study
Authors: van der Straaten Tirza F K , Briaire Jeroen J , Dirks Evelien , Soede Wim , Rieffe Carolien , Frijns Johan H M 
Published: March 2021

AbstractChildren with hearing loss (HL) are at risk for a lower educational achievement. This longitudinal study compared the school career of a nationwide Dutch cohort with and without HL based on descriptive data of the governmental authority Statistics Netherlands. From 2008 to 2018, 3,367,129 children, of whom 1,193 used cochlear implants (CIs) and 8,874 used hearing aids (HAs), were attending primary and/or secondary education. Sixty-one percent of children with HL attended mainstream and 31% special primary education. Compared to mainstreamed pupils without HL, mainstreamed pupils with HL achieved lower levels for language and mathematics in primary education but eventually attended comparable types of secondary education. Children with HL attending special primary education attained lower types of secondary education compared to mainstreamed peers with and without HL. These findings suggest that future educational (and as a result professional) attainment of a child with HL depends on the type of primary educational setting.
Poor school connectedness in adolescence and adulthood depressiveness: a longitudinal theory-driven study from the Northern Sweden Cohort
Authors: Gunnarsdóttir Hrafnhildur , Hensing Gunnel , Hammarström Anne 
Published: March 2021

AbstractBackgroundFoundations for mental health are laid early in family and school life. Family climate embraces the emotional connections within a family, and school connectedness embraces both functional and affective dimensions of relationship with school. Based on the lack of theory-driven and longitudinal epidemiological studies addressing public mental health, the aim of this longitudinal study was to investigate the associations between adolescents’ school connectedness, family climate and depressiveness in adulthood, by relying on Bronfenbrenner’s ecological theory.MethodsThe data are from the Northern Swedish Cohort, and the sample consists of 481 women and 526 men born in 1965 who participated in data collection at age 16, 21, 30 and 43. The generalized linear model method with random intercepts was used to examine the associations between family climate and school connectedness and depressiveness in adulthood.ResultsPoor school connectedness was associated with depressiveness in adulthood [β = 0.038 (95% CI 0.018–0.058) P ≤ 0.001], but poor family climate was not [β = 0.014 (95% CI −0.004–0.032)]. No difference in associations was observed between those experiencing social/material adversities in adolescence.ConclusionsThis study shows that poor school connectedness in adolescence can affect depressiveness in adulthood. The study confirms the complex processes that determine mental health and proposes a theoretical approach appealing to public mental health research. In addition, this study concludes that more life-course studies are needed to advance the knowledge of the mechanisms behind the associations between family climate and school connectedness and depressiveness in adulthood.
A closed-loop optogenetic screen for neurons controlling feeding in Drosophila
Authors: Lau Celia K S , Jelen Meghan , Gordon Michael D 
Published: March 2021

Abstract
Feeding is an essential part of animal life that is greatly impacted by the sense of taste. Although the characterization of taste-detection at the periphery has been extensive, higher order taste and feeding circuits are still being elucidated. Here, we use an automated closed-loop optogenetic activation screen to detect novel taste and feeding neurons in Drosophila melanogaster. Out of 122 Janelia FlyLight Project GAL4 lines preselected based on expression pattern, we identify six lines that acutely promote feeding and 35 lines that inhibit it. As proof of principle, we follow up on R70C07-GAL4, which labels neurons that strongly inhibit feeding. Using split-GAL4 lines to isolate subsets of the R70C07-GAL4 population, we find both appetitive and aversive neurons. Furthermore, we show that R70C07-GAL4 labels putative second-order taste interneurons that contact both sweet and bitter sensory neurons. These results serve as a resource for further functional dissection of fly feeding circuits.
Resolving the Early Divergence Pattern of Teleost Fish Using Genome-Scale Data
Authors: Takezaki Naoko 
Published: March 2021

Abstract
Regarding the phylogenetic relationship of the three primary groups of teleost fishes, Osteoglossomorpha (bonytongues and others), Elopomorpha (eels and relatives), Clupeocephala (the remaining teleost fish), early morphological studies hypothesized the first divergence of Osteoglossomorpha, whereas the recent prevailing view is the first divergence of Elopomorpha. Molecular studies supported all the possible relationships of the three primary groups. This study analyzed genome-scale data from four previous studies: 1) 412 genes from 12 species, 2) 772 genes from 15 species, 3) 1,062 genes from 30 species, and 4) 491 UCE loci from 27 species. The effects of the species, loci, and models used on the constructed tree topologies were investigated. In the analyses of the data sets (1)–(3), although the first divergence of Clupeocephala that left the other two groups in a sister relationship was supported by concatenated sequences and gene trees of all the species and genes, the first divergence of Elopomorpha among the three groups was supported using species and/or genes with low divergence of sequence and amino-acid frequencies. This result corresponded to that of the UCE data set (4), whose sequence divergence was low, which supported the first divergence of Elopomorpha with high statistical significance. The increase in accuracy of the phylogenetic construction by using species and genes with low sequence divergence was predicted by a phylogenetic informativeness approach and confirmed by computer simulation. These results supported that Elopomorpha was the first basal group of teleost fish to have diverged, consistent with the prevailing view of recent morphological studies.
Brain Small-Worldness Properties and Perceived Fatigue in Mild Cognitive Impairment
Authors: Kukla Bennett , Anthony Mia , Chen Shuyi , Turnbull Adam , Baran Timothy M , Lin Feng V 
Published: March 2021

Abstract

Background
Perceived fatigue is among the most common complaints in older adults and is substantially influenced by diminished resources or impaired structure of widespread cortical and subcortical regions. Alzheimer’s disease and its preclinical stage—mild cognitive impairment (MCI)—are considered a brain network disease. It is unknown, however, whether those with MCI will therefore perceive worse fatigue, and whether an impaired global brain network will worsen their experience of fatigue.

Methods
In this pilot case–control study of age-, sex-, and education-matched MCI and their cognitively healthy counterparts (HCs), perceived fatigue was measured using Multidimensional Fatigue Inventory, and diffusion tensor imaging tractography data were analyzed using graph theory methods to explore small-worldness properties: segregation and integration.

Results
Perceived fatigue was more severe in MCI than HCs. Despite a trend for greater network alterations in MCI, there were no significant group differences in integration or segregation. Greater perceived fatigue was related to higher segregation across groups; more perceived fatigue was related to higher segregation and lower integration in MCI but not HCs.

Conclusion
Findings of this study support the notion that altered whole-brain small-worldness properties in brain aging or neurodegeneration may underpin perceived fatigue.
The Politics of the Anthropocene: Temporality, Ecology, and Indigeneity
Authors: Randazzo Elisa , Richter Hannah 
Published: March 2021

AbstractThe notion of the Anthropocene has become an instrumental backdrop against which post-foundational social theory and political research frame political action in a way that defies modern certainty and, somewhat paradoxically, anthropocentrism, under conditions of drastic ecological changes. But what exactly is the theoretical promise of the Anthropocene? This paper seeks to explore what the concept can offer to critical social science and, conversely, how these critical approaches define and locate the analytical and the political purchase of the Anthropocene, through the critical lens of Indigenous scholarship. The paper genealogically retraces the transition from a science-led, discontinuous-descriptive to a continuous-ontological conceptualization of the Anthropocene. It then unpacks how the notions of ecological relationality and non-human agency deployed in the latter closely parallel certain lines of argumentation in Indigenous thought and politics. Drawing on critical Indigenous studies, the paper formulates a critique of how relational perspectives enfold alternative ontologies and politics within an overarching Anthropocene ontology that is not only problematically universalizing, but also replaces the genuine engagement with differences and resistance.
Supplementing organic-complexed or inorganic Co, Cu, Mn, and Zn to beef cows during gestation: postweaning responses of offspring reared as replacement heifers or feeder cattle
Authors: Harvey Kelsey M , Cooke Reinaldo F , Colombo Eduardo A , Rett Bruna , de Sousa Osvaldo A , Harvey Lorin M , Russell Jason R , Pohler Ky G , Brandão Alice P 
Published: March 2021

Abstract
One hundred and ninety nonlactating, pregnant beef cows (¾ Bos taurus and ¼ Bos indicus; 138 multiparous and 52 primiparous) were assigned to this experiment at 117 ± 2.2 d of gestation (day 0). Cows were ranked by parity, pregnancy type (artificial insemination = 102, natural service = 88), body weight (BW) and body condition score, and assigned to receive a supplement containing: (1) sulfate sources of Cu, Co, Mn, and Zn (INR; n = 95) or (2) an organic complexed source of Cu, Mn, Co, and Zn (AAC; Availa4; Zinpro Corporation, Eden Prairie, MN; n = 95). The INR and AAC provided the same daily amount of Cu, Co, Mn, and Zn, based on 7 g of the AAC source. From day 0 to calving, cows were maintained in a single pasture and segregated 3 times weekly into 1 of 24 individual feeding pens to receive treatments. Calves were weaned on day 367 (200 ± 2 d of age), managed as a single group for a 45-d preconditioning period (days 367 to 412), and transferred to a single oat (Avena sativa L.) pasture on day 412. Heifer calves were moved to an adjacent oat pasture on day 437, where they remained until day 620. Heifer puberty status was verified weekly (days 437 to 619) based on plasma progesterone concentrations. Steer calves were shipped to a commercial feedlot on day 493, where they were managed as a single group until slaughter (day 724). Plasma cortisol concentration was greater (P = 0.05) in AAC calves at weaning but tended to be less (P = 0.10) on day 370 compared with INR calves. Mean plasma haptoglobin concentration was greater (P = 0.03) in INR vs. AAC calves during preconditioning, and no treatment effects were noted (P = 0.76) for preconditioning average daily gain (ADG). Puberty attainment was hastened in AAC heifers during the experiment (treatment × day; P &lt; 0.01), despite similar (P = 0.39) ADG between treatments from days 412 to 620. Expression of myogenin mRNA in the longissimus muscle was greater (P = 0.05) in INR vs. AAC heifers on day 584. No treatment effects were detected (P ≥ 0.24) for steer ADG from day 412 until slaughter, nor for carcass quality traits. Hepatic mRNA expression of metallothionein 1A was greater (P = 0.02) in INR vs. AAC steers on day 586. In summary, supplementing Co, Cu, Zn, and Mn as organic complexed instead of sulfate sources to beef cows during the last 5 mo of gestation did not improve performance and physiological responses of the steer progeny until slaughter, but hastened puberty attainment in the female progeny reared as replacement heifers.