bluuebunny/crossref_metadata_2025_split huggingface dataset:
SÍFILIS CONGÊNITA NO TOCANTINS, 2007-2017
Authors: VANTI THAYNARA RODRIGUES NERES , OLIVEIRA CINTYA ALVES DE , Silva Allethéa Robertha Souza e 
Published: May 2021

RESUMO: A sífilis é uma doença infecciosa de acometimento sistêmico causada pelo Treponema pallidum. O indivíduo adquire a doença por meio da relação sexual desprotegida ou pela transmissão vertical. O contágio do concepto ocorre mais frequentemente no útero podendo, no entanto, ocorrer no canal vaginal, se houver lesão ativa, durante a realização do parto. O diagnóstico de sífilis congênita é de caráter mais complexo que o diagnóstico de sífilis gestacional. Principalmente devido 50%, aproximadamente, dos recém-nascidos serem assintomáticos. Objetivo: Descrever o perfil epidemiológico dos casos notificados de sífilis congênita no período 2007-2017 no estado do Tocantins, Brasil. Métodos: Realizou-se estudo descritivo com dados do Sistema de Informação de Agravos de Notificação (Sinan). Resultados: No período de 2007 a 2017 a nível nacional foram notificados 158.269 casos de sífilis congênita destes, 1690 casos foram no estado do Tocantins, ocorrendo uma elevação de 270,4% nesses 10 anos, sendo o terceiro estado com maior número de casos da região norte. Conclusão: A taxa de sífilis congênita aumentou consideravelmente nos últimos anos, fato que deve ser investigado pois a sífilis congênita pode ser evitada com diagnostico e terapêutica adequados.
CONTAMINAÇÃO EM SUPERFÍCIES DE UTI APÓS LIMPEZA/DESINFECÇÃO NO BRASIL: UMA REVISÃO INTEGRATIVA
Authors: Azevedo Resende de Lourenzo Mayara , Cirilo de Lima Keiliane , Bezerra Almeida Nathallya , Aires Aguiar Aline 
Published: May 2021

Introdução: as superfícies de UTI podem ser colonizadas por microrganismos resultando em risco para os pacientes através das infecções relacionadas à assistência à saúde. Objetivo: identificar a contaminação de superfícies de UTI antes e após processos de limpeza/desinfecção. Metodologia: realizou-se uma busca sistemática da literatura nas bases de dados SCIELO, LILACS, PUBMED, MEDLINE e Periódicos da CAPES. Descritores usados: unidade de terapia intensiva, antígenos de superfície, bactéria, microbiota, desinfecção, serviço hospitalar de limpeza. Resultados: foram selecionados artigos publicados no período de 2010 a 2020, nos idiomas português e inglês, contendo estudos desenvolvidos no Brasil. A busca resultou em 53 artigos, após a aplicação dos critérios de inclusão e exclusão foram selecionados 07 para compor a revisão. Os resultados apontam que 100% dos artigos analisados apresentaram algum grau de contaminação microbiológica nas superfícies de UTI após o processo de limpeza/desinfecção. Múltiplos fatores estão envolvidos com a eficiência do processo e a remoção dos microrganismos, como: produtos, procedimentos, técnica de fricção ou desempenho dos responsáveis pela execução. Também pode ocorrer pós desinfecção a contaminação cruzada das superfícies pelas mãos dos profissionais. Conclusão: recomenda-se a padronização dos procedimentos de limpeza/desinfecção, criação de rotinas de monitoramento, incentivo à higiene das mãos, bem como, a realização de novos estudos detalhando a ação dos produtos e as técnicas mais eficazes.
Palavras-Chave: Unidade de terapia intensiva. Antígenos de superfície. Microbiota. Desinfecção. Serviço hospitalar de limpeza.
STING protects against cardiac dysfunction and remodelling by blocking autophagy
Authors: Xiong Rui , Li Ning , Wang Wei , Wang Bo , Jiang Wenyang , Geng Qing 
Published: May 2021

Abstract
Background

Heart failure, which is characterized by cardiac remodelling, is one of the most common chronic diseases in the aged. Stimulator of interferon genes (STING) acts as an indispensable molecule modulating immune response and inflammation in many diseases. However, the effects of STING on cardiomyopathy, especially cardiac remodelling are still largely unknown. This study was designed to investigate whether STING could affect cardiac remodelling and to explore the potential mechanisms.
Methods

In vivo, aortic binding (AB) surgery was performed to construct the mice model of cardiac remodelling. A DNA microinjection system was used to trigger STING overexpression in mice. The STING mRNA and protein expression levels in mice heart were measured, and the cardiac hypertrophy, fibrosis, inflammation and cardiac function were also evaluated. In vitro, cardiomyocytes stimulated by Ang II and cardiac fibroblasts stimulated by TGF-β to performed to further study effects of STING on cardiac hypertrophy and fibroblast. In terms of mechanisms, the level of autophagy was detected in mice challenged with AB. Rapamycin, a canonical autophagy inducer, intraperitoneal injected into mice to study possible potential pathway.
Results

In vivo, the STING mRNA and protein expression levels in mice heart challenged with AB for 6 weeks were significantly increased. STING overexpression significantly mitigated cardiac hypertrophy, fibrosis and inflammation, apart from improving cardiac function. In vitro, experiments further disclosed that STING overexpression in cardiomyocytes induced by Ang II significantly inhibited the level of cardiomyocyte cross-section area and the ANP mRNA. Meanwhile, TGF-β-induced the increase of α-SMA content and collagen synthesis in cardiac fibroblasts could be also blocked by STING overexpression. In terms of mechanisms, mice challenged with AB showed higher level of autophagy compared with the normal mice. However, STING overexpression could reverse the activation of autophagy triggered by AB. Rapamycin, a canonical autophagy inducer, offset the cardioprotective effects of STING in mice challenged with AB. Finally, further experiments unveiled that STING may inhibit autophagy by phosphorylating ULK1 on serine757.
Conclusions

STING may prevent cardiac remodelling induced by pressure overload by inhibiting autophagy, which could be a promising therapeutic target in heart failure.
Preparation of Cellulose-based fluorescent materials as coating pigment by use of reversible DMSO/DBU/CO2 system
Authors: Cao Qinghua , Dai Jinyue , Bao Xin , Zhang Zhenyu , Liu Fei , Feng Yuhong , Na Haining , Zhu Jin 
Published: May 2021

Abstract
A series of cellulose-based fluorescent materials are prepared under relative mild conditions by use of the reversible DMSO/DBU/CO2 system to utilize as coating pigments. Through the observation under 365nm UV light, the cellulose-based fluorescent materials exhibit good fluorescence response and bright color. Furthermore, due to the limitation of the molecular skeleton of cellulose, the intrinsic aggregation caused quenching phenomenon commonly existed in conventional organic fluorescent pigments can be effectively inhibited, which is very helpful to retain good fluorescence response in epoxy-based coating material and its coating films. Moreover, the addition of cellulose-based fluorescent materials also increases the mechanical properties of the coating film. The increase of tensile strength and tensile modulus respectively reaches ~ 39% and ~ 66%. Solvent resistance and thermal property of the coating films generally remain unchanged. The fabrication of cellulose-based fluorescent materials in DMSO/DBU/CO2 system provides a feasible way to develop the functional application of cellulose.
Tropopause Folding Events to the East of Tibetan Plateau in Boreal Summer and their Remote Relation to the Circulation Anomalies over Northeastern Atlantic
Authors: Zhu Chuandong , Ren Rongcai 
Published: May 2021

Abstract
This study investigates the occurrence of tropopause folding (TF) events to the east of Tibetan Plateau (ETP) (TF–ETP) in boreal summer. Firstly, it is revealed that, anomalously frequent TF–ETP occurrence in summer, always corresponds to a significant dipole rainfall anomaly pattern over China, with negative rainfall anomalies over the upper and middle reaches of the Yangtze and Yellow river valleys, and positive rainfall anomalies over eastern China. Secondly, the South Asian High (SAH) center over Tibetan Plateau (TP) is found to be anomalously stronger when occurrence of TF–ETP events is frequent. Further diagnosis indicates that, the TF–ETP occurrence is related to an eastward propagating Rossby wave train (RWT) that originates from a barotropic low anomaly center over the northeastern Atlantic (NEA) about one–week before. The RWT propagates downstream via Western Europe, the west of Baikal and down to East Asia along the mid-latitude westerlies, and is connected to a high anomaly center over the north rim of TP, which enhances the SAH center over TP. The enhanced SAH in turn favors the southward and downward PV intrusion and the subsequent occurrence of TF–ETP. Furthermore, the low anomaly center that initiates the RWT is related to dynamical forcing of transient eddy activity over the NEA, which induces the low via eddy-forced upper divergence and its pumping. Finally, such local and remote processes are confirmed in a typical TF–ETP case. The ERA–Interim daily fields during 1979–2018 is used.
Temporal Stability Analysis for the Evaluation of Spatial and Temporal Patterns of Surface Water Quality
Authors: Zhang Xiaobin , Ma Ligang , Zhu Yihang , Lou Weidong , Xie Baoliang , Sheng Li , Hu Hao , Zheng Kefeng , Gu Qing 
Published: May 2021

Abstract
Better characterizing the spatio-temporal pattern of water quality would increase the ability to effectively manage water resources. This study applied the concept of temporal stability analysis (TSA) to explore the temporal characteristics of spatial variability in surface water quality. Monitoring data from 41 monitoring stations in Qiantang River, China for 2017–2019 were used to assess four indicators: dissolved oxygen (DO), permanganate index (CODMn), total phosphorus (TP), and ammonia nitrogen (NH3–N). A Spearman’s rank correlation for each pair of monitoring times demonstrated that the spatial pattern of water quality was maintained for a specific period of time. The TP concentration was most temporally stable compared with the other three indicators across the study area. A temporal analysis of relative differences was applied to examine the temporal stability of the sampling sites. The mean concentrations, with acceptable errors, were estimated from the representative sites identified for the four water quality indicators. Different metrics were assessed to identify the temporally stable sites. The standard deviation of the relative difference (SDRD) and index of temporal stability (ITS) were found to be better for identifying the stable sites compared to the mean absolute bias error (MABE) and root mean square error (RMSE) in this study. A correlation analysis between the temporal stability indices and potential influencing factors showed that land use proportions (forest, built-up land, and agricultural land), and socio-economic indicators (gross domestic product [GDP] and population density) were closely associated with the temporal stability of water quality. The results showed evidence that the TSA method was feasible and effective in identifying the temporal stability of surface water quality and optimizing the water quality monitoring program. This study’s method and findings can help improve surface water quality monitoring strategies and water resource management.
Development of a Novel Fuzzy Logic-Based Wetland Risk Assessment Approach for the Management of Freshwater Wetland Ecosystems
Authors: Hasani Sajad Soleymani , Mojtahedi Alireza , Reshadi Mir Amir Mohammad 
Published: May 2021

Abstract
In the present study, a new wetland risk assessment approach based on the fuzzy inference system (FIS) was developed and proposed for the first time to improve the traditional ESCOM's wetland classification and risk assessment index (WCRAI). As two of the twenty-five Iranian wetlands of international importance, the Kani Barazan and Choghakhor wetlands were selected as the study areas due to their significant roles in protecting the biodiversity of their regions. The wetlands are supported by the international Ramsar Convention on Wetlands to mandate and encourage the local authorities for their conservation and sustainable exploitation. In this regard, the Iranian Department of Environment, in cooperation with UNDP/GEF, selected these wetlands to demonstrate new approaches to managing the wetland areas protected by the Conservation of Iranian Wetlands Project (CIWP). A real-time wetland monitoring station with hydrological instruments, including water level, air temperature, air humidity, and water quality multi-parameter sensors recording water temperature, pH, specific conductance, and dissolved oxygen, was implanted at the deepest part of both wetlands. The manual sampling of water quality parameters was also carried out periodically during specific time intervals. The relative importance of the wetland health indicators involved in the FIS was determined using the analytic hierarchy process (AHP). In turn, the health level categories of both wetlands were assessed using the traditional and proposed wetland risk assessment approaches. The efficiency of the proposed method was evaluated with the considered scenarios, and it was shown to be a more flexible and appropriate approach for wetland health assessment. Furthermore, the observed differences between the health level categories of the first case study indicated the importance of using the AHP-FIS method to improve the traditional ESCOM's WCRAI.
Capacity and Modeling of Acid Blue 113 Dye Adsorption onto Chitosan Magnetized by Fe2O3 Nanoparticles
Authors: Al-Musawi Tariq , Mengelizadeh Nezamaddin , AL-Rawi Orabi Shareef , Balarak Davoud 
Published: May 2021

Abstract
A chitosan polymer was magnetized by coating with magnetite Fe2O3 nanoparticles, and the resultant material (C–Fe2O3) was first characterized through scanning electron microscopy equipped with energy–dispersive X-ray spectroscopy, transmission electron microscopy, atomic force microscopy, thermogravimetric, X-ray diffractometry, Fourier transform infrared spectroscopy, Brunauer–Emmett–Teller, and point of zero charge analyses. C–Fe2O3 was then employed as a separable and efficient adsorptive agent to remove acid blue 113 (AB113) dye from aqueous solution. The removal efficiency was optimized at different environmental parameter values (pH: 3–11, C–Fe2O3 dose: 0.1–1 g/L, initial AB113 dye concentration: 10–100 mg/L, adsorption time: 0–300 min, and temperature: 388–318 K). Under optimum conditions, an AB113 dye removal efficiency of 99.68% was achieved. In addition, the effect of the presence of NaCl, NaNO3, Na2CO3, and MgSO4 ions on the AB113 dye removal efficiency could be ranked as NaCl > NaNO3 > MgSO4 > Na2CO3. The statistical analysis using the coefficient of determination, root mean square error, chi-square test, sum of squared errors, and average relative error showed that the Freundlich and pseudo-second-order equations were the best mathematical models for fitting the isothermal and kinetics data. Further kinetics analyses showed that the adsorption of AB113 molecules on C–Fe2O3 active sites was dominated by the intraparticle diffusion process. Thermodynamic parameters indicated that the AB113 dye adsorption process was favorable, endothermic, and spontaneous. Furthermore, an increase in temperature had a positive impact on AB113 dye removal. The regeneration study confirmed the excellent shelf life of C–Fe2O3, with only a slight loss in the removal efficiency (< 7%) being detected after six operational cycles of AB113 dye adsorption. Compared with other adsorbents, C–Fe2O3 was more effective for the adsorption of AB113 dye, with an adsorption uptake up to 128 mg/g.
Natural Resources, Institutional Quality and Financial Development in GCC Member Countries: Visiting ‘Resource Curse Hypothesis’ by DCCE Estimation
Authors: Faheem Muhammad , Chaudhry Imran Sharif , Hussain Sadam 
Published: May 2021

Abstract
The main purpose of the study is to check whether natural resource rent affects the financial development or supporting resource curse hypothesis by employing a recently developed estimation technique by Chudik and Pesaran (2015) over 1985 to 2017 in GCC member countries. The novelty of this methodology is to consider structural breaks and the heterogeneity issues that are common in panel data. The results of DCCE estimates are in support of resource hypothesis that natural resource rent hurt financial development. Additionally, this study takes moderation of institutional quality to check the threshold point or turning point where natural resource rent effect becomes positive. Our results of interaction term postulate that a higher level of institutional quality mitigates the adverse effect of natural resource rent on financial development. The study results recommend the policy of natural resource rent in the presence of high institutional quality should continue because it improves the financial development in GCC member countries.
Bifurcation Analysis and H∞ Control of a Stochastic Competition Model with Time Delay
Authors: Zhang Yue , Zhang Jing 
Published: May 2021

Abstract
In this paper, we study a stochastic competition model with time delay and harvesting.We first simplify it through the stochastic center manifold reduction principle and stochastic averaging method as a one-dimensional Markov diffusion process. Singular boundary theory and an invariant measure are applied to analyze stochastic stability and bifurcation. The T-S fuzzy model of the system is constructed, and the H∞ fuzzy controller is designed to eliminate the bifurcation phenomenon through a linear matrix inequality approach. Numerical simulation is used to demonstrate our results.
Fixed-time formation tracking for multiple nonholonomic wheeled mobile robots based on distributed observer
Authors: Sun Fenglan , Li Hao , Zhu Wei , Kurths Jürgen 
Published: May 2021

Abstract
This paper studies the distributed fixed-time formation tracking problem of multiple nonholonomic wheeled mobile robots system over directed fixed and switching topologies. Through a classical nonlinear transformation, the formation control problem is transformed into a consensus problem. New control protocols based on a distributed observer are proposed. The communication topology between multiple nonholonomic wheeled mobile robots is directed, which can reduce the energy loss of communication. Some sufficient conditions of multiple robots achieving the expected formation pattern are given. All follower robots can track the leader's trajectory, form the desired formation shape within a fixed settling time, and make the leader in the geometric center of the formation. By adopting graph theory, Lyapunov stability method and fixed time theory, one can obtain an upper bound of the settling time, and the settling time is independent of the system's initial states. Finally, two examples are presented to illustrate the potential correctness of the main results.
Candidemia in Internal Medicine: Facing The New Challenge
Authors: Brescini Lucia , Mazzanti Sara , Morroni Gianluca , Pallotta Francesco , Masucci Annamaria , Orsetti Elena , Montalti Roberto , Barchiesi Francesco 
Published: May 2021

Abstract
Candidemia is an alarming problem in critically ill patients including those admitted in Internal Medicine Wards (IMWs). Here, we analyzed all cases of candidemia in adult patients hospitalized over nine years (2010–2018) in IMWs of a 980-bedded University Hospital of Ancona, Italy. During the study period, 218/505 (43%) episodes of candidemia occurred in IMWs patients. The cumulative incidence was 2.5/1000 hospital admission and increased significantly over time (p = 0.013). Patients were predominantly male, with a median age of 68 years. Cardiovascular diseases and solid tumors were the most frequent comorbidities. Candida albicans accounted for 51% of the cases, followed by C. parapsilosis (25%), C. tropicalis (9%) and C. glabrata (7%). Thirty-day mortality was 28% and did not increased significantly over time. By multivariate logistic regression analysis, the presence of neutropenia (OR 7.247 [CI95% 1,368 − 38,400; p = 0.020]), pneumonia (OR 2.323 [CI95% 1,105-4,884; p = 0.026]), and being infected with C. albicans (OR 2.642 [95% CI 1,223-5,708; p = 0.013) emerged as independent predictors of mortality. The type of antifungal therapy did not influence the outcome. Overall, these data indicate that patients admitted to IMWs are increasingly at higher risk of developing candidemia. Mortality rate remains high and significantly associated with both microbiologic- and host-related factors.
An RCT of a decision aid to support informed choices about taking aspirin to prevent colorectal cancer and other chronic diseases: A study protocol for the SITA (Should I Take Aspirin?) Trial
Authors: Milton Shakira , McIntosh Jennifer , Macrae Finlay , Chondros Patty , Trevena Lyndal , Jenkins Mark , Walter Fiona M. , Taylor Natalie , Boyd Lucy , Saya Sibel , Karnchanachari Napin , Novy Kitty , Forbes Carmody , Gutierrez Javiera Martinez , Broun Kate , Whitburn Sara , McGill Sarah , Fishman George , Marker Julie , Shub Max , Emery Jon 
Published: May 2021

Abstract
Background: Australian guidelines recommend that all people aged 50-70 years old actively consider taking daily low-dose aspirin (100–300mg per day) for 2.5 to 5 years to reduce their risk of colorectal cancer (CRC). Despite the change of national CRC prevention guidelines, there has been no active implementation of the guidelines into clinical practice. We aim to test the efficacy of a health consultation and decision aid, using a novel expected frequency tree (EFT) to present the benefits and harms of low dose aspirin prior to a general practice consultation with patients aged 50-70 years, on informed decision-making and uptake of aspirin. Methods: Approximately five to seven general practices in Victoria, Australia will be recruited to participate. Patients 50-70 years old, attending an appointment with their general practitioner (GP) for any reason, will be invited to participate in the trial. Two hundred fifty-eight eligible participants will be randomly allocated 1:1 to intervention or active control arms using a computer-generated allocation sequence stratified by general practice, sex, and mode of trial delivery (face-to-face or teletrial). There are two co-primary outcomes: informed decision-making at one-month post randomisation, measured by the Multi-dimensional Measure of Informed Choice (MMIC), and self-reported daily use of aspirin at six months. Secondary outcomes include decisional conflict at one-month and other behavioural changes to reduce CRC risk at both time points. Discussion: This trial will test the efficacy of novel methods for implementing national guidelines to support informed decision-making about taking aspirin in 50-70-year-olds to reduce risk of CRC and other chronic diseases.