bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design for mass customisation, design for manufacturing, and design for supply chain: A review of the literature
Authors: Hou Shixuan , Gao Jie , Wang Chun 
Published: September 2021

AbstractThis survey provides a review of the fundamental approaches to design for mass customisation (DFMC), design for manufacturing (DFM) and design for supply chains (DFSC). The key term here is design while mass customisation, manufacturing and supply chain are the contexts from which the respective design objectives are derived. While these three areas of design are closely related, they have different focusses, which is reflected in the broader range of approaches proposed in the literature. The authors look at the literature through the lens of the product, process, and supply chain optimisation, with a variety of objectives ranging from improving product quality and variety while reducing costs, minimising environmental impacts and optimising supplier manufacture cooperation. In addition to the reviews of the approaches to DFMC, DFM and DFSC, recommendations on their practical system implementations are provided. While the authors acknowledge that the richness of the literature of each of the three design areas warrants a dedicated literature review, the main purpose of this survey is to pursue an integrated view on the three design issues faced by modern manufacturers and provide them and other related practitioners with a summary of representative approaches in the literature. Although it was not intended to conduct an exhaustive literature review of the literature, researchers from academia may still find the work useful by looking at the interactions of the three design areas from the perspective of joint‐decision making, which is the angle from which the literature is approached.
Design of miniaturised printed quadrifilar helix antenna with isoflux coverage and wide‐angle circular polarisation
Authors: Liu Hongmei , Luo Bin , Wang Jiahui , Fang Shaojun , Wang Zhongbao 
Published: September 2021

AbstractIn the study, a miniaturised printed quadrifilar helix antenna (PQHA) with isoflux coverage and wide‐angle circular polarisation is presented. It is composed of a three‐stage stepped impedance spiral arm and open stubs. Each of the three‐stage spiral arms has different pitches and number of turns. For the last‐stage spiral arm, meander lines are used. The proposed PQHA features the characteristics of wide bandwidth, isoflux radiation, small size, and wide‐angle circular polarisation. Moreover, in order to feed the proposed PQHA, a miniaturised quad‐feed network is designed to provide equal amplitude signals with sequential orthogonal phases. For demonstration, a prototype is designed, fabricated, and measured. The overall size of the proposed antenna is 88 × 88 × 132 mm (0.44 λ0 × 0.44 λ0 × 0.66 λ0). The results show that isoflux radiation with a coverage of about ±60° is realised from 1.40 to 1.62 GHz (14.6%) while maintaining more than 10 dB return loss and larger than 200° 3‐dB axial ratio beamwidth.
AC power supply circuit architecture for a miniaturised retinal prosthesis device
Authors: Mori Yasuto , Chia‐Chi Chang , Endo Hiroki , Hata Maho , Shodo Kenzo , Terasawa Yasuo , Noda Toshihiko , Tokuda Takashi , Haruta Makito , Tashiro Hiroyuki , Sasagawa Kiyotaka , Ohta Jun 
Published: September 2021

AbstractThis study proposes an alternating current (AC)‐driven retinal prosthesis device using an implantable CMOS‐LSI chip that can control multiple electrodes. The proposed device uses AC power with the electrical grounds of the main and stimulation units separated to reduce the possibility of current leakage and to improve safety. The stimulation unit implanted in the eye cannot include large capacitor chips for ground separation. To solve this problem, large capacitor chips are mounted on the implantable control unit that supplies power, not on the stimulating device, and a cooperative mode of operation is devised. In this way, it is realised that a circuit configuration that achieves both miniaturisation and improved power supply efficiency. This study verifies the functionality of the proposed circuit. The results suggest that power supply and stimulation operations are possible through coupling capacitors. In addition, this stimulation operation can be performed continuously.
ATOMIUM: halide molecules around the S-type AGB star W Aquilae
Authors: Danilovich T. , Van de Sande M. , Plane J. M. C. , Millar T. J. , Royer P. , Amor M. A. , Hammami K. , Decock L. , Gottlieb C. A. , Decin L. , Richards A. M. S. , De Beck E. , Baudry A. , Bolte J. , Cannon E. , De Ceuster F. , de Koter A. , Etoka S. , Gobrecht D. , Gray M. , Herpin F. , Homan W. , Jeste M. , Kervella P. , Khouri T. , Lagadec E. , Maes S. , Malfait J. , McDonald I. , Menten K. M. , Montargès M. , Müller H. S. P. , Pimpanuwat B. , Sahai R. , Wallström S. H. J. , Waters L. B. F. M. , Wong K. T. , Yates J. , Zijlstra A. 
Published: September 2021

Context. S-type asymptotic giant branch (AGB) stars are thought to be intermediates in the evolution of oxygen- to carbon-rich AGB stars. The chemical compositions of their circumstellar envelopes are also intermediate but have not been studied in as much detail as their carbon- and oxygen-rich counterparts. W Aql is a nearby S-type star, with well-known circumstellar parameters, making it an ideal object for in-depth study of less common molecules.
Aims. We aim to determine the abundances of AlCl and AlF from rotational lines, which have been observed for the first time towards an S-type AGB star. In combination with models based on PACS observations, we aim to update our chemical kinetics network based on these results.
Methods. We analyse ALMA observations towards W Aql of AlCl in the ground and first two vibrationally excited states and AlF in the ground vibrational state. Using radiative transfer models, we determine the abundances and spatial abundance distributions of Al35Cl, Al37Cl, and AlF. We also model HCl and HF emission and compare these models to PACS spectra to constrain the abundances of these species.
Results. AlCl is found in clumps very close to the star, with emission confined within 0′′.1 of the star. AlF emission is more extended, with faint emission extending 0′′.2 to 0′′.6 from the continuum peak. We find peak abundances, relative to H2, of 1.7 × 10−7 for Al35Cl, 7 × 10−8 for Al37Cl, and 1 × 10−7 for AlF. From the PACS spectra, we find abundances of 9.7 × 10−8 and ≤10−8, relative to H2, for HCl and HF, respectively.
Conclusions. The AlF abundance exceeds the solar F abundance, indicating that fluorine synthesised in the AGB star has already been dredged up to the surface of the star and ejected into the circumstellar envelope. From our analysis of chemical reactions in the wind, we conclude that AlF may participate in the dust formation process, but we cannot fully explain the rapid depletion of AlCl seen inthe wind.
Role of miRNAs in Breast Cancer-induced Bone Disease
Authors: Haider Marie-Therese , Zarrer Jennifer , Smit Daniel J. , Hesse Eric , Taipaleenmäki Hanna 
Published: September 2021

AbstractBone is the most common site of breast cancer recurrence. Despite the increasing
knowledge about the metastatic process and treatment advances, the disease still
remains incurable once the cancer cells actively proliferate in bone. Complex
interactions between cancer cells and cells of the bone microenvironment (BME)
regulate the initiation and progression of metastatic tumor growth in bone. In
particular, breast cancer cells shift the otherwise tightly balanced bone
remodeling towards increased bone resorption by osteoclasts. Cellular
interactions in the metastatic BME are to a large extent regulated by secreted
molecules. These include various cytokines as well as microRNAs (miRNAs), small
non-coding RNAs that post transcriptionally regulate protein abundance in
several cell types. Through this mechanism, miRNAs modulate physiological and
pathological processes including bone remodeling, tumorigenesis and metastasis.
Consequently, miRNAs have been identified as important regulators of cellular
communication in the metastatic BME. Disruption of the crosstalk between cancer
cells and the BME has emerged as a promising therapeutic target to prevent the
establishment and progression of breast cancer bone metastasis. In this context,
miRNA mimics or antagonists present innovative therapeutic approaches of high
potential for interfering with pathological bone – cancer cell
interactions. This review will discuss the role of miRNAs in the tumor-BME
crosstalk in vivo and will emphasize how this could be targeted by miRNAs
to improve therapeutic outcome for patients with breast cancer bone
metastases.
The Role of microRNAs in Osteoporosis Diagnostics
Authors: Hackl Matthias , Semmelrock Elisabeth , Grillari Johannes 
Published: September 2021

AbstractMicroRNAs (miRNAs) are short (18–24 nucleotides) non-coding RNA sequences
that regulate gene expression via binding of messenger RNA. It is estimated that
miRNAs co-regulate the expression of more than 70% of all human genes,
many of which fulfil important roles in bone metabolism and muscle function.
In-vitro and in-vivo experiments have shown that the targeted loss of miRNAs in
distinct bone cell types (osteoblasts and osteoclasts) results in altered bone
mass and bone architecture. These results emphasize the biological relevance of
miRNAs for bone health.MiRNAs are not only considered as novel bone biomarkers because of their
biological importance to bone metabolism, but also on the basis of other
favorable properties: 1) Secretion of miRNAs from cells enables
“minimally invasive” detection in biological fluids such as
serum. 2) High stability of miRNAs in serum enables the retrospective analysis
of frozen blood specimens. 3) Quantification of miRNAs in the serum is based on
the RT-PCR - a robust method that is considered as the gold standard for the
analysis of nucleic acids in clinical diagnostics.With regard to osteoporosis, it has been shown that many of the known risk
factors are characterized by distinct miRNA profiles in the affected tissues: i)
age-related loss of bone mass, ii) sarcopenia, iii) changes in estrogen
metabolism and related changes Loss of bone mass, and iv) diabetes. Therefore,
numerous studies in recent years have dealt with the characterization of miRNAs
in the serum of osteoporosis patients and healthy controls, and were able to
identify recurring miRNA patterns that are characteristic of osteoporosis. These
novel biomarkers have great potential for the diagnosis and prognosis of
osteoporosis and its clinical outcomes.The aim of this article is to give a summary of the current state of knowledge on
the research and application of miRNA biomarkers in osteoporosis.
Homöopathie und Biochemie – zum 200. Geburtstag von
Wilhelm Schüßler
Authors: Baschin Marion 
Published: September 2021

ZusammenfassungDer 200. Geburtstag von Wilhelm Schüßler wird zum Anlass
genommen, verbindende und trennende Aspekte zwischen den therapeutischen
Ansätzen der Homöopathie und der Biochemie zu beleuchten.
Schüßler hat seinen Ansatz aus der Homöopathie heraus
entwickelt und sich in den ersten Jahren nach der Formulierung seiner
„Abgekürzten Therapie“ um eine Verbindung zwischen
seinen Überlegungen und der Lehre Hahnemanns bemüht. Dies kann
für die Nutzung der sogenannten Schüßler-Salze in der
Praxis Impulse geben.
The Interval Between Matches Significantly Influences Injury Risk in Field Hockey
Authors: Mason Joel , Rahlf Anna Lina , Groll Andreas , Wellmann Kai , Junge Astrid , Zech Astrid 
Published: September 2021

AbstractFixture congestion increases injury risk in football, but how it impacts other sports is unclear. The aim of this study was to identify associations between match density and injury incidence in field hockey players. Injury data from a prospective cohort study of professional and youth players was analysed in two ways. Inter-match intervals were clustered into<2424-hours, 3–7-days, and 13 + days, and injury rate ratios (IRR) were calculated to identify differences between clusters in match injuries. Separately, a Lasso-penalised Poisson regression model was used to determine the association between match load across the previous 24-hours, 3-days, 7-days and 14-days, and match and training injuries. Injury rates in matches within 24-hours of the previous match were mostly significantly higher when compared to matches after 3–7-days (IRRs: 3.78; 6.77, P = 0.003; 0.005). While a higher match exposure in the preceding 24-hour and 3-day periods was associated with higher combined match and training injury rates (β̂ = 0.0001; 0.0018), a higher match exposure in the previous 7-and 14-day periods was associated with a reduced injury rate (β̂ = –0.0001; –0.0005). Due to the increased injury risk in matches 3-days and especially 24-hours following the previous fixture, match distribution should be cautiously planned.
Stereoselective Synthesis of the C19–C39 Fragment of Bastimolide A
Authors: Ghosh Subhash , Kumar Nemilikonda Sravan , Ramulu B. Janaki 
Published: September 2021

AbstractThis paper describes the synthesis of the C19–C39 fragment of the antimalarial natural product bastimolide A via addition of a functionalized C19–C26 alkyne fragment to a C27–C39 aldehyde fragment. Opening of a terminal epoxide and Noyori asymmetric reduction were used as key steps in the synthesis.
10.24.2 Product Subclass 2: Pyrimido[1,2-a]indoles and Related Benzo-Fused Ring Systems
Authors: Harris P. A. 
Published: September 2021

AbstractMethods for the synthesis of pyrimido[1,2-a]indoles and the related indolo[1,2-a]quinazoline and indolo[2,1-a]quinazoline ring systems are reviewed in this chapter. Although limited reports have been published to date, a variety of differing approaches to these heterocycles have been described.
Real-time stabilization of the alkali-metal transverse axis orientation in nuclear spin comagnetometer by biaxial differential detection
Authors: Lei Guanqun , Wu Wenfeng , Zhao Xinghua , Chai Zhen , Liu Zhanchao , Yuan Heng 
Published: September 2021

Axis orientation stability has a great effect on the long-term drift performance of nuclear spin comagnetometers that utilize alkali atoms to detect the magnetic moment of nuclear spin ensembles. Previous studies have analyzed the sensitivity influence of the misalignment angle and demonstrated a post-processing calibration method in the transverse polarized comagnetometer, but there is no study on the traditional longitudinally polarized setup. We propose an innovative biaxial differential detection method to monitor the misalignment angle in the longitudinally polarized comagnetometer and then eliminate it on-line. By monitoring the amplitude difference of a reference magnetic field’s projections in a rotated measurement frame, an error signal with good linearity is obtained. Experiments showed that any misalignment angle within (−π/4, π/4) can be successfully compensated to near 0 within about 1.5 s, which is fast enough compared to the drift rate of a practical device. The new detection method is robust and insensitive to many factors, such as direct component drift and scale factor inequality, so the method can be widely used in similar devices that acquire high accurate alignment of the axis orientation, such as the spin exchange relaxation-free magnetometer.
Influence of the dissociation unit on pressure and temperature distribution in arc chamber of ACB during the breaking process
Authors: Yin Nairui , Liu Hongwu , Shi Zongqian , Guan Ruiliang 
Published: September 2021

To void breakdown between busbars, the dissociation unit is applied in the arc chamber of an air circuit breaker (ACB) to cool down the hot gas exhausted from the vent of the arc chamber in the interrupting process. Cooling efficiency and flow resistance of the dissociation unit have important roles, which can greatly affect the safety of the low voltage switcher and interrupting performance of the arc chamber. The most common structure style of the dissociation unit is a multilayer metal wire mesh, and it has a complex microstructure. Then, it is unreasonable to directly simulate the dissociation unit due to the huge cost of calculation. In this study, the porous medium model is introduced and a combination of two different porous materials is applied to simplify the simulation model of the dissociation unit. Based on the porous model and simplified arc chamber model, the ACB with the dissociation unit is analyzed. The cooling effect and flow resistance of the dissociation unit are evaluated in the breaking process. By comparing experimental and simulated pressures in the arc chamber, this simulation approach is verified.
Impact of applied biaxial stress on the piezoelectric, elastic, and dielectric properties of scandium aluminum nitride alloys determined by density functional perturbation theory
Authors: Daoust P. , Côté Michel , Desjardins P. , Masut R. A. 
Published: September 2021

The effects of biaxial in-plane stress on the elastic, dielectric, and piezoelectric (PE) properties of c-axis textured thin film wurtzite phase scandium aluminum nitride (w-ScxAl1−xN) alloys have been calculated with density functional perturbation theory. The in-plane stress σR was kept below 1 GPa covering compressive and tensile values and applied to alloy supercells represented with special quasi-random structures. An increasingly tensile biaxial stress (σR &gt; 0) produces higher displacement-response internal-strain coefficients for the constituent atoms of the alloy and the related PE properties are more sensitive to σR when the fraction x increases. A significant rise of the relative dielectric permittivity ϵr,33η and softening of the stiffness coefficient c33E are also reported with σR &gt; 0. The effective thin film PE strain coefficient d33,f and coupling coefficient k33,f2 show a relative increase of 22% and 26%, respectively, at σR = 1 GPa and x = 0.438. Both tensile σR and x tend to decrease the c/a cell parameter ratio of the wurtzite structure with a significant impact on the PE coefficients. Based on the decomposition of the stiffness, dielectric, and PE coefficients as well as the structural data, it is suggested that tensile biaxial stress enhances the hexagonal character of w-ScxAl1−xN in a qualitatively similar manner as the scandium nitride fraction x does. The manufacture and PE characterization of a beneficially stressed thin film of w-ScxAl1−xN on a substrate of w-InyAl1−yN with adjusted x, y values are suggested to confirm the calculated values of d33,f.
Final report on the CIPM key comparison CCAUV.V-K5
Authors: Bruns Th , Nordmann D , Ripper G P , Winther J H , Hof C , Ruiz S , Pineda G da Silva , Nozato H , Zuo A , Dickinson L , Veldman C S , Kozlyakovskiy A , Shan C , Ivashchenko A , Allen R A 
Published: September 2021

Main text
The results of the ﬁfth CIPM key comparison (KC) in the area of vibration, here concerning sinusoidal acceleration, are presented.
This comparison was intended to build the foundation for subsequent regional key comparisons over the extended frequency range from 10 Hz to 20 kHz. Measurement results reported by 14 participants for magnitude and phase shift of complex charge sensitivity of single ended and back-to-back accelerometers were compared. A key comparison reference value has been deﬁned for each type of artifact, and the respective Degrees of Equivalence are reported. The ﬁnal report has been peer-reviewed and approved for publication by the CCAUV, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCAUV, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
A Single-Blinded Prospective Study on Using Botulinum Toxin Type A for Reducing Alar Mobility
Authors: Zhong Yehong , Cao Dejun , Zhou Sizheng , Duan Huichuan , Wei Min , Yu Zheyuan 
Published: September 2021

Abstract

Background
With widespread utilization of instant social media, people desire a minimally invasive treatment to improve alar dynamic aesthetic, but few practical procedures on reducing alar mobility have been conducted.

Objectives
This study aimed to verify the effects of botulinum toxin on reducing nasal alar mobility and provide a supplemental treatment of rhinoplasty.

Methods
This single-blind prospective study included a cohort of 20 participants with the desire to improve their alar dynamic aesthetic. The experimental group was injected with 3U botulinum toxin type A at dilator naris anterior, dilator naris vestibularis, levator labii superioris alaeque nasi, and dilator naris, and the control group received the equivalent of saline. Standardized facial movement (from rest to maximum smile without revealing teeth) was recorded with a 3-dimensional imaging system. The changes between rest and maximum smile statuses represented alar mobility and were generated by MOBILITY=WIDTHsmile−WIDTHrestWIDTHrest×100 % . Alar mobility and root mean square analysis were employed for postoperative evaluations.

Results
In the experimental group, alar flaring mobility decreased from 10.05% ± 6.40% to 4.91% ± 3.48%(P &lt; 0.05), and alar base mobility decreased from 16.83% ± 5.69% to 12.50% ± 4.89% (P &lt; 0.05), whereas no significant changes in alar mobility were found in the control group. In root mean square analysis, changes in the experimental group were significantly higher than in the control group (P &lt; 0.05).

Conclusions
Botulinum toxin type A can effectively restrain alar mobility without any significant adverse events and improve alar dynamic esthetic, which can serve as a minimally invasive method or supplemental treatment for rhinoplasty.

Level of Evidence: 2
Omics Notebook: robust, reproducible and flexible automated multiomics exploratory analysis and reporting
Authors: Blum Benjamin C , Emili Andrew 
Published: September 2021

Abstract

Summary
Mass spectrometry is an increasingly important tool for the global interrogation of diverse biomolecules. Unfortunately, the complexity of downstream data analysis is a major challenge for the routine use of these data by investigators from broader training backgrounds. Omics Notebook is an open-source framework for exploratory analysis, reporting and integrating multiomic data that are automated, reproducible and customizable. Built-in functions allow the processing of proteomic data from MaxQuant and metabolomic data from XCMS, along with other omics data in standardized input formats as specified in the documentation. In addition, the use of containerization manages R package installation requirements and is tailored for shared high-performance computing or cloud environments.

Availability and implementation
Omics Notebook is implemented in Python and R and is available for download from https://github.com/cnsb-boston/Omics_Notebook with additional documentation under a GNU GPLv3 license.

Supplementary information
Supplementary data are available at Bioinformatics Advances online.