bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Nonsteroidal Anti-inflammatory Drug, Zaltoprofen, Inhibits the Growth of Extraskeletal Chondrosarcoma Cells by Inducing PPARγ, p21, p27, and p53
Authors: Higuchi Takashi , Takeuchi Akihiko , Munesue Seiichi , Yamamoto Norio , Hayashi Katsuhiro , Harashima Ai , Yamamoto Yasuhiko , Tsuchiya Hiroyuki 
Published: May 2021

Abstract
There is no effective treatment except surgical resection for extraskeletal myxoid chondrosarcoma (EMC). Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor and a master transcription factor of adipogenesis-related genes and has been reported as an antitumor target for chondrosarcomas. Herein, we show that a nonsteroidal anti-inflammatory drug, zaltoprofen, induces the expression of PPARγ at mRNA and protein levels, following the induction of PPARγ-activating factors, such as Krox20, C/EBPβ, and C/EBPα, in human extraskeletal chondrosarcoma cells, H-EMC-SS. Zaltoprofen inhibited the proliferation of these cells in vitro. Upregulation of cell cycle checkpoint proteins, p21, p27, and p53, was observed upon treatment of cells with zaltoprofen, which probably resulted in the inhibition of proliferation of H-EMC-SS cells. Zaltoprofen treatment induced tumor necrosis, which could be due to its antiproliferative properties, and was well tolerated in a mouse model of EMC. Our results provide mechanistic insights into the therapeutic effect of zaltoprofen that should promote further studies on the rational use of this drug for effective treatment of EMC.
Neuroimaging Reveals Distinct Brain Glucose Metabolism Patterns Associated with Morphine Consumption in Two Inbreed Rat Models
Authors: Soto-Montenegro Mª Luisa , García Verónica , Lamanna-Rama Nicolás , López-Montoya Gonzalo , Desco Manuel , Ambrosio Emilio 
Published: May 2021

Abstract
Addiction vulnerability is the individual's risk of developing an addiction during their lifetime. A challenge in the neurobiology of drug addiction is understanding why some people become addicted to drugs. Here, we used positron emission tomography (PET) and statistical parametric mapping (SPM) to evaluate changes in brain glucose metabolism in response to chronic morphine self-administration (MSA) in two rat strains with different vulnerability to drug abuse, Lewis (LEW) and Fischer 344 (F344). Four groups of animals were trained to self-administer morphine or saline for 15 days. 2-deoxy-2-[18F]-fluoro-D-glucose (FDG)-PET studies were performed on the last day of MSA (acquisition phase) and after 15 days of withdrawal. PET data were analyzed using SPM12. LEW-animals self-administered more morphine injections per session than F344-animals. We found significant brain metabolic differences between LEW and F344 strains in the cortex, hypothalamus, brainstem, and cerebellum. In addition, the different brain metabolic patterns observed after the MSA study between these rat strains indicate differences in the efficiency of neural substrates to translate the drug effects, which could explain the differences in predisposition to morphine abuse between one individual and another. These findings have important implications for the use of these rat strains in translational morphine and opiate research.
Incidental Chronic Lymphocytic Leukemia Diagnosed Following Radical Prostatectomy for Prostate Cancer : a Case Report
Authors: Tlili Ghassen , ammar houssem , majdoub wiem , dziri sonia , farhat waad , akacha emir , gupta rahul , ahmed khaled ben , azzabi awatef , jaidane mehdi 
Published: May 2021

Abstract
Background: chronic lymphocytic leukemia (CLL) patients have a high risk of occurrence of secondary cancers. This risk is three times higher for all cancers and eight times higher for skin cancer. The coexistence of CLL and adenocarcinoma of the prostate is rare.Case presentation: We report a case of 66-year-old man who underwent radical prostatectomy for prostate carcinoma. The final histopathological diagnosis of Gleason 7 adenocarcinoma of the prostate with incidental chronic lymphocytic leukemia (CLL) was made. No further investigations or treatment was offered due to the age, low grade and the stage of the disease. At last follow-up of 12 months, the patient is alive, without disease progression for both lymphoma and prostate with PSA value of 0.1 ng/ml.Conclusion: Early detection of lymphoma after radical prostatectomy will allow optimal management. The analysis of this link requires therefore additional investigations.
Assessment of Root Morphology and Canal Configuration of Maxillary Premolars in a Saudi Subpopulation: A Cone-Beam Computed Tomographic Study
Authors: Al‑Zubaidi Saad M. , Almansour Moazzy I. , Mansour Nada N. Al , Alshammari Ahad S. , Alshammari Ahad F. , Altamimi Yazeed S. , Madfa Ahmed A. 
Published: May 2021

Abstract
Background
The objective of the current study was to use CBCT to look into the root canal morphology of maxillary premolars in a Saudi Arabian subpopulation and associate the results to existing canal morphology classifications. The sample size for this analysis was 500 right and left untreated maxillary premolars with fully formed roots from 250 Saudi residents (125 male and 125 female). The following observations were made using CBCT on the teeth related: (1) The number and morphology of roots; (2) The canal morphology for each root according to Vertucci's classification. The frequency and similarities between the right and left sides, as well as between females and males, were studied. The Chi-square test was used to assess the results.
Results
Of the 500 maxillary first premolars investigated, 199 teeth had one root (39.8%), whilst 293 (58.6%) were two-rooted. Three-rooted maxillary first premolars were found in 8 (1.6%). For maxillary second premolars, 416 premolars had one root (83.2%), while 79 (15.8%) had two roots and the rest 5 (1.0%) were three roots. There were significant differences of number of root were found between groups (p > 0.05). For maxillary first premolar, Type IV was the most frequent, accounting for 57.8% of the sample (n = 289), followed by type II (32.8%, n = 164). For maxillary second premolar, Type I was mainly occurrence 302 (60.4%), followed by Type II (16.4%, n = 82).
Conclusion
The more common of maxillary first premolars had two roots and two root canals, while one root and one root canal was the majority anatomical configuration for maxillary second premolars. Additional canal forms do occur on occasion, and clinicians should pay close attention to them.
Image Quality of Abdominal Ultrasonography After Esophagogastroduodenoscopy Is Preserved by Using Carbon Dioxide Insufflation
Authors: Suda Tsuyoshi , Shirota Yukihiro , Takimoto Hiroaki , Tsukada Yasunori , Takishita Kensaku , Nadamura Takahiro , Miyazawa Masaki , Hodo Yuji , Wakabayashi Tokio 
Published: May 2021

Abstract
Because bowel gas deteriorates the image quality of abdominal ultrasonography (AUS), it is common to perform AUS prior to esophagogastroduodenoscopy (EGD). This one-way order limits the availability of examination appointments. To evaluate whether EGD using insufflation of carbon dioxide (CO2), which is rapidly absorbed by the gastrointestinal mucosa, preserves the image quality of AUS performed subsequently, we designed a non-inferiority test in which each subject underwent AUS, EGD with CO2 insufflation, and a second AUS. All saved AUS moving images were randomized and evaluated using a four-point Likert scale that divides the depiction rate by 25%. Sample size was calculated to be 26 and 30 subjects were enrolled. The mean and 95% confidence interval (CI) of the image quality score at pre- and post-EGD AUS were 3.54 [3.48–3.60] and 3.46 [3.39–3.52], respectively. The difference in the means was 0.08, corresponding to a 2% depiction rate. The effect size was 0.172. The image quality of post-EGD AUS was not inferior, as demonstrated by the 97.5% CI of the difference, which did not cross the non-inferiority margin of –0.40 corresponding to depiction rate of –10%. Because EGD using CO2 insufflation does not appreciably deteriorate the image quality of AUS performed subsequently, it is permissible to perform EGD prior to AUS.
The Effect of Particle Distribution to the Sintering Properties of Al2o3 Ceramic Formed by Stereolithography
Authors: QIAN CHUCHU , Hu Kehui , Wang Haoyuan , Feng Qian , Lu Zhigang , Li Peijie , Lu Kuan 
Published: May 2021

Abstract
This work studied the effect of particle size gradation on the structure and sintering properties of alumina ceramics manufactured by stereolithography after sintering, including room temperature flexural strength, sintering shrinkage, porosity and microstructure morphology. Seven different particle size gradations from coarse to fine were studied, and each particle size gradation was coarse particles: fine particles=6:4. With the increase of the sintering temperature, the degree of sintering and the bonding strength of the interface increased, the shrinkage in all directions, and the bending strength and the closed porosity increased, the open porosity decreased. For the same sintering temperature, the flexural strength and shrinkage in all directions decreased and the open porosity increased with the increase of particle size. The ratio of the height (4mm) shrinkage of each particle size to the length (50mm) shrinkage is about 1.5 times. Due to the presence of the lateral edge resin layer, the width shrinkage of the coarse particles was different from the length shrinkage but closer to the height shrinkage. The width shrinkage gradually approached the length shrinkage as the particle size decreased. When the gradation ratio is the same, and the particle size was ten times different (30μm/5μm, 3μm/0.5μm; 20μm/3μm, 2μm/0.3μm), there was a big difference. When the sintering temperature was above 1500℃, the differences of sintering properties of the comparison groups are 2~10 times. Considering the alumina-based ceramic core, 20/3 has been evaluated comprehensively. It maintains excellent flexural strength and porosity under the condition of slight shrinkage.
Meiosis and male fertility in F1 interspecific hybrids (Passiflora vitifolia vs. Passiflora hatschbachii)
Authors: Souza Analu Cruz , Souza Margarete Magalhães , Silva Gonçalo Santos , Lavinscky Manuella Palmeira , Souza Viviane de Oliveira , Freitas Jôsie Cloviane de Oliveira 
Published: May 2021

Abstract
Interspecific hybrids can be studied using methodologies in which the male gamete with high reproduction potential, viability, and fertility is prioritized. Passiflora species, with lush, showy, and exotic colors, have great potential for the ornamental plant market. In addition, artificial Passiflora hybrids were developed without many difficulties because of weak reproductive barriers. Thus, meiotic and post-meiotic behaviors were analyzed with 2% acetic carmine staining. Confirmation of interspecific hybridization was performed using SSR markers and GISH technique was used to detect genomic differentiation. The pollen viability of the parental and hybrids genotypes was tested using Alexander solution, fluorescein diacetate and in vitro germination tests were performed using culture medium. The meiotic behavior was regular and displayed haploid number n = 9 with nine bivalent (II) chromosomal, pairing in 90% of the cells in diakinesis. There was a significant difference (p < 0.05) in terminal and interstitial chiasma frequencies. Meiotic irregularities observed were as follows: early and/or delayed chromosomes, disorientation of spindle fibers, transverse spindles, tripolar spindles, and asynchrony; and consequently irregular post-meiotic products were observed: monads, dyads, triads, and polyads. GISH was used in the interspecific hybrids and pairing between homeologous chromosomes, and bivalent and tetravalent formation were observed. From this study, we could conclude that hybrid genotypes are fertile and pollen grains are viable and can be used in breeding programs. We also hypothesize that interspecific hybrid genotypes of Passiflora can be obtained with regular meiosis, which could be viable and fertile.
Will Iran achieve the SDG 3.4 at national and sub- national levels?
Authors: Haghdoost Ali Akbar , Farzadfar Farshad , Yoosefi Moein , Mansori Kamyar , Larijani Bagher , Baneshi Mohammad Reza , Shadmani Fatemeh Khosravi 
Published: May 2021

Abstract
In this study, different scenarios have been used to project Iran’s chance to achieve SDG 3.4. Unconditional Probability of Dying (UPOD) through the Bayesian model averaging for four major categories of NCDs was projected on the basis of Death Registry System data at the national and sub-national levels. The prevalence of the risk factors was projected by 2030 based on STEPs data and additional studies. Assuming that the global reduction in risk factors proposed by WHO is performed in Iran, UPOD was projected again and then the possibility of achieving the target was estimated. If the current trend continues, the UPOD will be reduced from 17.5 % (95% UI: 16.3–19.2) in 2010 and 14.7% (13.3–16.2) in 2015 to 10.8% (7.9–14.3) in 2030. If the risk factors are reduced to the global target level, 68236 deaths in 2010 and 54418 deaths in 2015 baselines will be avoided. By 2030, the UPOD after subtracting the avoidable deaths, will be 5.44 (3.51–7.39) in 2010 and 6.55 (5.00- 8.13) in 2015 baselines. This way some provinces will meet SDG 3.4. If the current trend continues, Iran will and will not achieve the SDG 3.4 in 2010 and 2015 baselines, respectively. However, if the global target set for reducing risk factors is achieved, Iran will meet all expectations in SDG 3.4 except in Asthma and COPD. Therefore, effective interventions are recommended to be designed and followed to reduce Asthma and COPD.
Experimental Study on the Adverse Effect of Gel Fracturing Fluid on Gas Sorption Behavior for Illinois Coal
Authors: Huang Qiming , Li Jun , Liu Shimin , Wang Gang 
Published: May 2021

Abstract
Hydraulic fracturing is an effective technology for coal reservoir stimulation. After fracturing operation and flowback, a fraction of fracturing fluid will be essentially remained in the formation which ultimately damages the flowability of the formation. In this study, we quantify the gel-based fracturing fluid induced damages on gas sorption for Illinois coal in US. We conducted the high-pressure methane and CO2 sorption experiments to investigate the sorption damage due to the gel residue. The infrared spectroscopy tests were used to analyze the evolution of the functional group of the coal during fracturing fluid treatment. The results show that no significant chemical alteration of coal due to the fracturing fluid injection, and the damage of sorption is attributed to the physical blockage and interactions. As the concentration of fracturing fluid increases, the density of residues on the coal surface increases and the adhesion film becomes progressively denser. The adhesion film on coal can apparently reduce the number of adsorption sites for gas and lead to a decrease of gas sorption capacity. In addition, the gel residue can decrease the interconnectivity of pore structure of coal which can also limit the sorption capacity by isolating the gas from the potential sorption sites. For the low concentration of fracturing fluid, the Langmuir volume was reduced to less than one-half of that of raw coal. After the fracturing fluid invades, the desorption hysteresis of methane and CO2 in coal was found to be amplified. The impact on the methane desorption hysteresis is significantly higher than CO2 does. The reason for the increasing of hysteresis may be that the adsorption swelling caused by the residue adhered on the pore edge, or the pore blockage caused by the residue invasion under high gas pressure. The results of this study quantitatively confirm the fracturing fluid induced gas sorption damage on coal and provide a baseline assessment for coal fracturing fluid formulation and technology.
Racial and Ethnic Disparities in Diagnostic Efficacy of Comprehensive Genetic Testing for Sensorineural Hearing Loss
Authors: Florentine Michelle M , Rouse Stephanie L , Stephans Jihyun , Conrad David , Czechowicz Josephine , Matthews Ian R , Meyer Anna K , Nadaraja Garani S , Parikh Rajan , Virbalas Jordan , Weinstein Jacqueline E , Chan Dylan K 
Published: May 2021

Abstract
Understanding racial/ethnic disparities in diagnostic rates of genetic testing is critical for health equity. We sought to understand the extent and cause of racial/ethnic disparities in diagnostic efficacy of comprehensive genetic testing (CGT) for sensorineural hearing loss (SNHL). We performed a retrospective cohort study at two tertiary children’s hospitals on a diverse cohort of 240 consecutive pediatric patients (76% publicly insured, 82% non-White) with SNHL of unknown etiology who underwent CGT. Definite and possible molecular diagnoses were assigned for each patient, representing the likelihood of a genetic cause of hearing loss. Associations between race/ethnicity and diagnostic rates were examined. 3.8 ± 2.1 variants were detected per patient; this frequency did not vary between White/Asian and Hispanic/Black cohorts. Overall, 82% of variants were Variants of Unknown Significance (VUS). Compared with White/Asian subjects, variants identified among Hispanic/Black children were less likely to be known (15% vs. 24%, p < 0.001), and Hispanic/Black children were less likely to have a definite molecular diagnosis (10% vs. 37%, p < 0.001). Expanding molecular diagnostic criteria to include predicted deleterious VUSs reduced these disparities between White/Asian and Hispanic/Black children, with comparable molecular diagnostic rates (41% vs. 35%, p = 0.46). The adjusted odds ratio for definite genetic diagnosis in Black/Hispanic children compared with White/Asian children was 0.18. These results demonstrate the extent of racial/ethnic disparities in diagnostic efficacy of comprehensive genetic testing. Consideration of deleterious VUSs reduced these disparities, highlighting the need for increased inclusion of underrepresented groups in genetic hearing-loss studies to clinically validate these variants.
Identification of Malignancy-Associated Haemophagocytic Lymphohistiocytosis By 18F-FDG PET/CT Based Multivariate Models in Clinical Practice
Authors: Yang Xu , Lu Xia , Kan Ying , Wang Wei , Zhang Shuxin , Liu Lei , Li Jixia , Yang Jigang 
Published: May 2021

Abstract
Purpose: 18F-FDG PET/CT is often used for detection of malignancy in newly diagnosed haemophagocytic lymphohistiocytosis (HLH), with acceptable sensitivity but relatively low specificity. The aim of this study was to improve the diagnostic ability of 18F-FDG PET/CT to identify malignancy in HLH by a combination of 18F-FDG PET/CT and clinical parameters. Methods: A cohort of patients with secondary HLH (n=71, age≥14 years) was retrospectively reviewed and pre-therapeutic variables of 18F-FDG PET/CT and laboratory were collected. Patients were divided into two groups: malignancy-associated HLH (M-HLH) (n=22) and non-malignancy-associated HLH (NM-HLH) (n=49). The variables were analyzed by Mann-Whitney U or Pearson Chi-Square test and the nomograms were constructed by multivariate binary logistic regression. The predictors were also ranked by decision-tree analysis. Results: Asymmetry distribution of hypermetabolic lymph nodes was more commonly observed in M-HLH (p=0.002). SUVmax-bone lesions, SUVmax-lymph nodes and C-reactive protein were selected to construct the model. This model displayed a good predictive performance with the area under receiver-operating-characteristic (ROC) curve of 0.884 (95%CI: 0.791-0.978). At an appropriate cut-off value, the sensitivity and specificity of identifying M-HLH reached 86.4% (65.1%-97.1%) and 87.2% (74.3%-95.2%), respectively. The decision tree integrating SUVmax-bone lesions and SUVmax-lymph nodes achieved a high sensitivity (86.4%) and specificity (87.8%) for identification of malignancy.Conclusion: 18F-FDG PET/CT can be a practical technique for identifying M-HLH and the models constructed by 18F-FDG PET/CT features alone or combined with clinical parameters are able to detect malignancy with better accuracy than visual analysis of 18F-FDG PET/CT images.
A Scientometric Appraisal of IASLIC Bulletin (2013-2017)
Authors: Karkee Prabin , Sinha Sudha 
Published: May 2021

Abstract
This study aims to analyse the contributions in IASLIC Bulletin –an official organ or a leading library science journal published by IASLIC. The total 97 articles were published during the period 2013 – 2017. The study covers the year-wise, institutions-wise, state-wise distribution of contributions, authorship pattern, citation analysis, length of the contributions etc. The study shows that most of the contributions of this journal are contributed by joint authors and state-wise distribution shows that most of the contributions are contributed from West Bengal. Citation analysis of 1369 citations includes finding out number of citations per volume, types of publications cited and preparing of ranked list of cited journals in contributions of this journal. The study reveals that journals are the most cited publication amongst the library and information scientists. Annals of Library and Information Studies is the most cited journal in the contributions of this journal.
Adjuvant Chemotherapy is an Additional Option for Locally Advanced Gastric Cancer After Radical Gastrectomy with D2 Lymphadenectomy: A Retrospective Control Study
Authors: Su Xiangqian , Chen Lei , Zhang Chenghai , Yao Zhendan , Cui Ming , Xing Jiadi , Yang Hong , Zhang Nan , Liu Maoxing , Xu Kai , Tan Fei , Li Yuzhe , Jiang Beihai 
Published: May 2021

Abstract
Background: This study compared the long-term efficacy of different durations of adjuvant chemotherapy for patients with gastric cancer after radical gastrectomy with D2 lymphadenectomy.Methods: We retrospectively identified 428 patients with stage II–III gastric cancer who underwent D2 gastrectomy between 2009 and 2016. Patients were divided into four groups according to the duration of adjuvant chemotherapy, including 0 week (no adjuvant, group A), 20 to 24 weeks (completed 7-8 cycles every 3 weeks or 10-12 cycles every 2 weeks, group B), and 12 to18 weeks (completed 4-6 cycles every 3 weeks or 6-9 cycles every 2 weeks, group C), and less than 12 weeks (received up to 3 cycles every 3 weeks or 5 cycles every 2 weeks, group D). The chemotherapy regimens included SOX, XELOX, and FOLFOX. Five-year overall survival (OS) and disease-free survival (DFS) were analyzed.Results: The five-year DFS rates for groups A, B, C, and D were 50, 68.0, 65.4, and 50.0%, respectively, and the 5-year OS rates were 52.3, 73.7, 72.0, and 53.3%, respectively. DFS and OS were higher in group B than in groups A and D. Similarly, patients in group C were more likely to have better DFS and OS than those in groups A and D. Meanwhile, there were no significant differences in DFS and OS between groups B and C. In multivariate analyses, the number of adjuvant chemotherapy cycles was a significant prognostic factor. Conclusions: To reduce toxicity and maintain efficacy, fluorouracil and oxaliplatin doublet adjuvant chemotherapy administered for 4–6 cycles every 3 weeks or 6–9 cycles every 2 weeks might be a favorable option for patients with stage II–III gastric cancer after D2 gastrectomy. Prospective multicenter clinical trials with large sample sizes are necessary to verify these findings.