bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-COVID-19 illness trajectory: a multisystem investigation.
Authors: Berry Colin , Morrow Andrew , Sykes Robert , McIntosh Alasdair , Kamdar Anna , Bagot Catherine , Barrientos Pauline , Bayes Hannah , Blyth Kevin , Briscoe Michael , Bulluck Heerajnarain , Carrick David , Church Colin , Corcoran David , Findlay Iain , Gibson Vivienne , Gillespie Lynsey , Grieve Douglas , Ho Antonia , Lang Ninian , Lowe David , Lennie Vera , Macfarlane Peter , Mayne Kaitlin , Mark Patrick , McConnachie Alex , McGeoch Ross , Mcginley Christopher , McKee Connor , Nordin Sabrina , Payne Alexander , Rankin Alastair , Ryan Nicola , Roditi Giles , Stobo David , Sattar Naveed , Allwood-Spiers Sarah , Touyz Rhian , Veldtman Gruschen , Weeden Sarah , Watkins Stuart , Welsh Paul , Wereski Ryan , Mangion Kenneth 
Published: November 2021

Abstract
Background: The pathophysiology and trajectory of multiorgan involvement in post-COVID-19 syndrome is uncertain. Methods: A prospective, multicenter, longitudinal, cohort study involving post-COVID-19 patients enrolled in-hospital or early post-discharge (visit 1) and re-evaluated 28-60 days post-discharge (visit 2). Multisystem investigations included chest computed tomography with pulmonary and coronary angiography, cardiovascular and renal magnetic resonance imaging, digital electrocardiography, and multisystem biomarkers. The primary outcome was the adjudicated likelihood of myocarditis.Results: 161 patients (mean age 55 years, 43% female) and 27 controls with similar age, sex, ethnicity, and vascular risk factors were enrolled from 22 May 2020 to 2 July 2021 and had a primary outcome evaluation. Compared to controls, at 28-60 days post-discharge, patients with COVID-19 had persisting evidence of cardio-renal involvement, systemic inflammation, and hemostasis pathway activation. Myocarditis was adjudicated as being not likely (n=17; 10%), unlikely (n=56; 35%), probable (n=67; 42%) or very likely (n=21; 13%). Acute kidney injury (odds ratio, 95% confidence interval: 3.40 (1.13, 11.84); p=0.038) and low hemoglobin A1c (0.26 (0.07, 0.87); p=0.035) were multivariable associates of adjudicated myocarditis. During convalescence, compared to controls, COVID-19 was associated with worse health-related quality of life (EQ5D-5L) (p<0.001), illness perception (p<0.001), anxiety and depression (p<0.001), physical activity (p<0.001) and predicted maximal oxygen utilization (ml/kg/min) (p<0.001). These measures were associated with adjudicated myocarditis.Conclusions: The illness trajectory of COVID-19 includes persisting cardio-renal inflammation, lung damage and hemostasis activation. Adjudicated myocarditis occurred in one in eight hospitalized patients and was associated with impairments in health status, physical and psychological wellbeing during community convalescence. Public registration: ClinicalTrials.gov identifier is NCT04403607.
Identification of biomarkers and signaling pathways during the treatment of multiple myeloma
Authors: Gu Hanming 
Published: November 2021

Abstract
Multiple myeloma (MM) is an incurable hematologic malignancy, which is characterized by increased bone marrow plasma cells, osteolytic lesions, and anemia. Here, our aim is to characterize significant biomarkers and signaling pathways during the treatment of MM by using bioinformatic methods. The GSE180018 dataset was generated by DNBSEQ-G400 (Homo sapiens). The KEGG and GO analyses showed the biological processes such as " Protein export”, “Protein processing in endoplasmic reticulum”, “Vibrio cholerae infection”, “Fc gamma R-mediated phagocytosis" are mainly affected in FOXM1 KO MM cells. Moreover, we identified the significant genes including CD44, NOTCH1, SELL, RAC2, HSPA8, VAV1, DDIT3, PLK1, HYOU1, ITGAL in FOXM1 KO MM cells. Therefore, our study may provide further guidance for the drug development of MM.
Sharing cities with avian scavengers: sustainable development in social-ecological systems
Authors: Gupta Urvi , Kumar Nishant 
Published: November 2021

Abstract
Correlations in the timings of vulture collapse and rapid urbanisation in South Asia have affected the benefit trade-offs concerning conservation-breeding for vulture restoration. We show how the loss of vultures 30 years ago has led to the extinction of experience amongst people in South Asia who are co-adapted to various animal species within shared landscapes. We conducted ethnography that focused on avian scavengers (vultures, kites and crows) in Delhi to unpack how salience and charisma for avian scavengers link with socio-cultural legends. Perceptions about avian scavengers were based on birds’ appearance, behaviour, and ecosystem services. Anthropomorphisation mediated human-animal co-adaptation and drove ritual feeding of commensals that opportunistically consume garbage. Conflated with ethnoecology, such human-constructed niches supported enormous animal populations in the region and drove mutual tolerance. Prior evaluations of scavengers’ niche from biophysical perspectives alone have, therefore, overlooked links between vultures and animal husbandry practices. It undermined competitive release on commensals that have responded by an increase in numbers and distribution, by taking advantage of ritual feeding and people’s affiliative attitudes. The absence of vultures limits the availability of spaces where animal husbandry can be practised. Conversely, expanding built-up spaces, overhead wires, fake news, and interference from competing scavengers will be impediments to vulture restoration. Conservation policies should examine immediate and long-term objectives of solid waste disposal, considering the odds against the attainment of the yesteryear functional ecology of vultures in South Asia. We conclude that wildlife restoration in urbanising tropical landscapes is a moving target, necessitating policies sensitive to progressive loss and/or changes in associative heritage due to shifting economic and cultural practices.
WITHDRAWN: Effects of Various Decolorizing Agents on Waste Cotton Fabric Dyed with Reactive Dyes
Authors: Li Ruojia , Yang Jianjun , Hu Jiewen , Zhang Gangqiang , Zhu Ping 
Published: November 2021

Abstract
Shorter fashion cycles have led to the rapid accumulation of unwanted and waste textiles. Compared to light-coloured textiles, the dark-coloured ones are more difficult to recycle and reuse, and their incineration and landfilling have negative environmental consequences. A technology that sufficiently decolorizes these textiles without causing major damage to their structure and properties is therefore useful. In this study, a waste cotton fabric containing vinyl sulfone reactive dyes was subjected to chemical treatments with different oxidants and/or reducing agent. The effects of various treatments on the fabric’s coloration and mechanical properties were compared. The two-step treatment using first Na2S2O4 and then H2O2 showed the best performance, achieving a CIE whiteness index of 65.1, 19.3% tensile strength loss, 1.8% weight loss, 93.5% decolouration rate, and a degree of polymerization of 747.7. A mechanism was proposed to explain the synergistic decolorization process.
Amelioration of depressive symptoms on Fawn-Hooded rats through the 'healthy' fecal microbiota transplantation
Authors: Hu Bing , Das Promi , Lv Xianglin , Shi Meng , Aa Jiye , Wang Kun , Duan Liping , Gilbert Jack A , Nie Yong , Wu Xiao-Lei 
Published: November 2021

Abstract
Background : Depression is a recurrent, heterogeneous mood disorder, occurring in more than 260 million people worldwide. Gut microbiome dysbiosis is associated with the development of depressive-like behaviors by modulating neuro-biochemical metabolism through the microbiome-gut-brain (MGB) axis. Fecal microbiota transplantation (FMT) has been proposed as a potential therapeutic solution for depression, but the therapeutic efficiency and mechanism is unknown. Results : We performed FMT from Sprague-Dawley (SD) rats ('healthy' controls) to Fawn-hooded (FH) rats (depression model). Pre-FMT, the FH rats exhibited significantly elevated depressive behaviors and distinct neurotransmitter and cytokine levels compared with SD rats. Post-FMT, FH recipients receiving SD microbiota showed reduced depressive behaviors, a significant increase in hippocampal neurotransmitters and a significant decrease of some hippocampal cytokines compared to the ones receiving FH microbiota. SD-FMT resulted in the FH recipients' gut microbiome resembling the SD donor, and a significant shift in the serum metabolome but not the hippocampal metabolome. Conclusions : SD-FMT was inferred to ameliorate recipients' physiochemical features of depression via the significant decrease of gut microbial species such as Dialister sp., which led to the recipients' metabolic modulation in serum and hippocampus through the enteric nervous system, the intestinal barrier and the blood-brain barrier. Our results provided new data pointing to multiple mechanisms of interaction for the impact of gut microbiome modulation on depression therapy.
Managing Neurosurgery in the Covid-19 Pandemic
Authors: Aminmansour Bahram , Mahmoudkhani Mehdi , Shafiei Mehdi , Sabouri Masih , Hematzadeh Mehrnaz , Tehrani Donya Shaybeni 
Published: November 2021

Abstract
BackgroundCovid-19 quickly spread around the world as an epidemic with potentially unknown hazards. Like its impacts on various occupations, neurosurgery has undergone changes due to the virus, including changes in surgical planning, inpatient and outpatient clinics, emergency management, and even academic activities. The present study was performed to determine neurosurgery challenges during the Covid-19 pandemic in Iran.MethodsThe present study was conducted as a mixed qualitative and quantitative study in 2021. In the qualitative section using the targeted sampling method, 11 members of the target community were selected using the available sampling method and completed a questionnaire. The qualitative part was conducted in two stages of reviewing texts and interviewing experts and in the quantitative part we evaluated the validity of the structure and the reliability of the questionnaire.ResultsThis study examined in detail all aspects of the effects of Covid-19 on neurosurgery. 9 dimensions and 61 items were identified as the challenges of neurosurgery during the Covid-19 pandemic. In order of importance, the aspects were: treatment outcome, manpower, management psychological and physical diseases, education and research, tools and physical space, ethics, financial implications and information technology.Conclusion﻿The outbreak of epidemics has different risks for specialties, among them neurosurgery. Accordingly, to observe patients' right to treatment, all necessary measures were first taken to provide instructions, regulations, policies and ethical guidelines.
Glitch in Contemporary Video Art (Iranian Glitch Artists)
Authors: Karimi Nazila 
Published: November 2021

Abstract
Glitch art is the use of digital or analog errors for cosmetic purposes by corrupting digital data or physical manipulation of electronic devices. What's called "glitch art" usually means visual bugs, whether in a still or moving image. It is difficult to classify and recognize a glitch. Primarily from a theoretical, scientific and non-artistic perspective, Glitch is the unexpected result of a malfunction. This artistic genre has influenced the art of video and has led to the interest of many video artists in this art genre, in this research, the works of video glitch of Iranian artists have been investigated and the techniques employed by the artist are described. In this regard, 6 samples of the works of different Iranian video glitch artists were selected and examined. According to the study, it can be concluded that Iranian video art artists have used this artistic genre in their works to express their intention and purpose.
The Fate of Indeterminate Liver Lesions: What Proportion Are Precursors of Hepatocellular Carcinoma? A Retrospective Follow-up Study
Authors: Cococcia Sara , Dutta Priti , Moghim Melika , Hogan Brian , Tanwar Sudeep , Marshall Aileen , Macdonald Douglas , Yu Dominic , O’Beirne James , Rosenberg William M , Trembling Paul M 
Published: November 2021

Abstract
BackgroundThe natural history and incidence of hepatocellular carcinoma (HCC) arising from indeterminate liver lesions is not well characterised. We aimed to define the incidence of HCC in a cohort of patients undergoing surveillance by magnetic resonance imaging (MRI) and estimate any associations with incident HCC.MethodsWe performed a retrospective follow-up study, identifying MRI scans in which indeterminate lesions had been reported between January 2006 and January 2017. Subsequent MRI scan reports were reviewed for incident HCC arising from indeterminate lesions, data were extracted from electronic patient records and survival analysis performed to estimate associations with baseline factors.ResultsOne hundred and nine patients with indeterminate lesions on MRI were identified. HCC developed in 19 (17%) patients over mean follow up of 4.6 years. Univariate Cox proportional hazards analysis found incident HCC to be significantly associated with baseline low platelet count (hazard ratio (HR) = 7.3 (95% confidence intervals (CI); 2.1 – 24.9), high serum alpha-fetoprotein level (HR = 2.7 (95% CI; 1.0 – 7.1)) and alcohol consumption above fourteen units weekly (HR = 3.1 (95% CI; 1.1 – 8.7)). Multivariate analysis, however, found that only low platelet count was independently associated with HCC (HR = 5.5 (95% CI; 0.6 – 5.1)).ConclusionsHCC arises in approximately one fifth of indeterminate liver lesions over 4.6 years and is associated with a low platelet count at the time of first diagnosis of an indeterminate lesion. Our data support a strategy of enhanced surveillance in patients with indeterminate lesions.
Risk Factors of Elevated Blood Ammonia Level in Epilepsy Patients Treated With Lamotrigine
Authors: Chen Yiqian , Chen Jingzhen , Zhuang Xiaorong , Chen Xingyu , Zeng Jianqi , Wang Ru , Miao Jiayin 
Published: November 2021

Abstract
Background
The aim of this study was to explore the effect of lamotrigine (LTG) on blood ammonia level in patients with epilepsy and identify risk factors affecting blood ammonia level.
Methods
This study included 91 epilepsy patients who were treated with LTG at Department of Neurology, Zhongshan Hospital, Xiamen University from January 2011 to April 2016, and were followed up for three years. Blood samples were taken during the interictal state and analyzed for blood LTG and ammonia levels.
Results
Total 46.1% of the samples exceeded the median blood ammonia level, and 2.1% of patients had hyperammonemia. Blood ammonia level was positively correlated with LTG blood concentration. LTG combined with valproic acid (VPA) therapy, seizure within one year, and elevated neutrophils affected blood ammonia level.
Conclusion
Blood ammonia level was significantly correlated with plasma concentration of LTG. LTG combined with VPA therapy, seizure within one year, and elevated neutrophils may be risk factors for elevated blood ammonia level in epilepsy patients treated with LTG.
Acute kidney injury after liver resection: A systematic review, meta-analysis and metaregression of factors affecting it
Authors: vasavada bhavin bhuendra , patel hardik 
Published: November 2021

Abstract

AimThis systematic review and meta-analysis aimed to study the incidence of acute kidney injury after liver resection and to analyze various factors affecting it by metaregression analysis.MethodsThe study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (2020) and MOOSE guidelines. The meta-analysis was done using Review Manager 5.4 and the JASP Team (2020). JASP (Version 0.14.1)(University of Amsterdam). Weighted percentage incidence with 95% confidence intervals were used. Univariate metaregression was done by DerSimonian-Laird methods. Factors with a p-value less than 0.05 in the univariate metaregression model were entered in the multivariate metaregression model. Heterogeneity was assessed using the Higgins I2 test. The random-effects model was used in meta-analysis.ResultsTotal 14 studies including 15510 patients were included in the final analysis. 1247 patients developed Acute Kidney Injury. Weighted Acute kidney injury percentage after liver resection was 15% with a 95% confidence interval of 11%-19%. On univariate metaregression analysis major hepatectomy (p=0.001), Underlying cirrhosis of liver (p=0.031), AKIN definition used (0.017), male sex (p<0.001), open surgery (p=0.032), underlying diabetes (0.026). On multivariate metaregression analysis major hepatectomy (p=0.003), underlying cirrhosis (p<0.001), male sex (p<0.001), AKIN classification used for defining acute kidney injury (p < 0.001, independently predicted heterogeneity and hence acute kidney injury.ConclusionLiver resection is associated with a high incidence of acute kidney injury. Major hepatectomy, male sex, underlying cirrhosis were independently predicting acute kidney injury.
Circ-CTNNB1 Drives Aerobic Glycolysis and Osteosarcoma Progression via m6A Modification Through Interacting With RBM15
Authors: Liu Hucheng , Xiao Jun , Li Bo , Chen Yajun , Zeng Jin , Hu Anpei , Zhou Song , Liu Yangyang , Yang Feng 
Published: November 2021

Abstract
Background

In a previous study, we have identified that circ-CTNNB1 (a circular RNA derived from CTNNB1) drives cancer progression through the activation of the Wnt/β-catenin signaling pathway in various tumors. However, the functions of circ-CTNNB1 in regulating osteosarcoma (OS, a highly malignant bone tumor in children and adolescents) remain unclear. In this study, we aimed to assess the role of circ-CTNNB1 in OS and identify the underlying mechanisms, which may contribute to the exploration of a potential therapeutic strategy for OS.
Methods

Circ-CTNNB1 was analyzed by qRT-PCR, and the results were confirmed by Sanger sequencing. The interaction and effects between circ-CTNNB1 and RNA binding motif protein 15 (RBM15) were analyzed through biotin-labeled RNA pull-down and mass spectrometry, in vitro binding, and RNA electrophoretic mobility shift assays. In vitro and in vivo experiments were performed to evaluate the biological functions and underlying mechanisms of circ-CTNNB1 and RBM15 in OS cells.
Results

Circ-CTNNB1 was highly expressed in OS tissues and predominantly detected in the nucleus of OS cells. Ectopic expression of circ-CTNNB1 promoted the growth, invasion, and metastasis of OS cells in vitro and in vivo. Mechanistically, circ-CTNNB1 interacted with RBM15 and subsequently promoted the expression of hexokinase 2 (HK2), glucose-6-phosphate isomerase (GPI), and phosphoglycerate kinase 1 (PGK1) through N6-methyladenosine (m6A) modification to facilitate the glycolysis process and activate OS progression.
Conclusions

These results indicate that oncogenic circ-CTNNB1 drives aerobic glycolysis and OS progression by facilitating RBM15-mediated m6A modification.
Influence of Surface Roughness on Shear Behaviours of Rock Joints Under Constant Normal Load and Stiffness Boundary Conditions
Authors: Han Guansheng , Zhou Yu , Liu Richeng , Tang Qiongqiong , Wang Xingkai , Song Leibo 
Published: November 2021

Abstract
The present study experimentally investigated the shear behaviors of artificial rock samples containing single or double joints under constant normal load (CNL) and constant normal stiffness (CNS) boundary conditions. The influence of surface roughness represented by joint roughness coefficient (JRC) on the evolutions of shear stress, normal stress, and normal displacement as well as the failure mode are analyzed and discussed. The results show that the peak shear stress and peak normal displacement are increased by 104% and 45.1% for single-joint specimens, which are increased by 50.1% and 182.8% for double-joint specimens when JRC ranges from 3.21 to 12.16 under CNL boundary conditions. Under a CNS boundary condition, the shear stress for single-joint and double-joint specimens increase slowly with the increase in shear displacement, and no obvious peak value is observed. However, the shear stress of double-joint specimen is lower than that of single-joint specimen due to that the former has a more complex joint structure. The surface damage degree of the upper joint is larger than that of the lower joint, and the surface failure of the lower joint lags behind that of the upper joint.
Molecular Targeting of Nrf2 and NFkB Signaling by 3-Acetyl-11-Keto- β -Boswellic Acid and Piperine Against Fluid Percussion Rat Model of Traumatic Brain Injury
Authors: Kundu Satyabrata , Singh Shamsher 
Published: November 2021

Abstract
Traumatic brain injury in rats through lateral fluid percussion injury (LFPI) model causes elevation of intracranial pressure which leads to impairment in motor and cognitive behaviour. 3-acetyl-11-keto-β-boswellic acid (AKBA) is a well-known anti-inflammatory agent but it has very low bioavailability. The current study was established to investigate the neuroprotective effect of AKBA in combination with bioenhancer piperine in LFPI induced TBI in experimental rats. Fluid percussion injury was introduced in the brain by delivering 50 mmHg of pressure for 3 minutes to the exposed brain. AKBA 25 mg/kg and 50 mg/kg orally and AKBA ((25 mg/kg, p.o.) in combination with piperine (2.5 mg/kg, p.o.) was administered from day 1 to day 14. On the 1st, 7th and 14th day, behavioural parameters were checked. On the 15th day, animals were euthanized. Then the cortex was isolated for the estimation of biochemical levels (MDA, nitrite, reduced GSH, catalase), neuroinflammatory markers (TNF-α, IL-1β, IL-6), and neurotransmitters (norepinephrine, dopamine, 5-HT, GABA, glutamate). From animals, hippocampus and cortex were isolated for histopathological analysis, and expressions of Nrf2 and NFkB were measured by the immunohistological study. Treatment with AKBA significantly attenuated LFPI induced abnormalities, biochemical and neurotransmitter changes in experimental rats. Further finding AKBA in combination with piperine significantly prevented histopathological changes, increased Nrf2 positive cells and reduced NFkB expression in the cortical region. The present study concluded that AKBA along with piperine achieved anti-oxidant, anti-inflammatory, neuro-modulatory effects as well as prevented neuronal injury via targeting Nrf2 and NFkB.
Teaching Mathematics in English for Elementary Students of Asak Paroki MKK
Authors: Herlina Clara 
Published: November 2021

Mathematics subject is considered difficult for most elementary students, especially when the subject is given in English. To be able to do math exercises in English, the students have to understand the math vocabulary and the concepts of math. The purpose of this community development program is to increase the elementary students’ ability in solving word math problems in English. The participants in this program are twenty elementary students who are included in ASAK Paroki MKK community. The program is created in the form of classroom teaching and activities. In this program, we teach them the basic concepts of math vocabulary, understanding the word problems and the solutions to the problems. We also use several related activities to make the lessons meaningful and comprehensible. The results show that the students are able to solve math problems in English correctly and confidently.