bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Binding Interaction of Raf Kinase Inhibitory Protein With the N-Terminal of C-Raf Through Molecular Docking and Molecular Dynamics Simulation
Authors: Parate Shraddha , Rampogu Shailima , Lee Gihwan , Hong Jong Chan , Lee Keun Woo 
Published: May 2021

Protein-protein interactions are indispensable physiological processes regulating several biological functions. Despite the availability of structural information on protein-protein complexes, deciphering their complex topology remains an outstanding challenge. Raf kinase inhibitory protein (RKIP) has gained substantial attention as a favorable molecular target for numerous pathologies including cancer and Alzheimer’s disease. RKIP interferes with the RAF/MEK/ERK signaling cascade by endogenously binding with C-Raf (Raf-1 kinase) and preventing its activation. In the current investigation, the binding of RKIP with C-Raf was explored by knowledge-based protein-protein docking web-servers including HADDOCK and ZDOCK and a consensus binding mode of C-Raf/RKIP structural complex was obtained. Molecular dynamics (MD) simulations were further performed in an explicit solvent to sample the conformations for when RKIP binds to C-Raf. Some of the conserved interface residues were mutated to alanine, phenylalanine and leucine and the impact of mutations was estimated by additional MD simulations and MM/PBSA analysis for the wild-type (WT) and constructed mutant complexes. Substantial decrease in binding free energy was observed for the mutant complexes as compared to the binding free energy of WT C-Raf/RKIP structural complex. Furthermore, a considerable increase in average backbone root mean square deviation and fluctuation was perceived for the mutant complexes. Moreover, per-residue energy contribution analysis of the equilibrated simulation trajectory by HawkDock and ANCHOR web-servers was conducted to characterize the key residues for the complex formation. One residue each from C-Raf (Arg398) and RKIP (Lys80) were identified as the druggable “hot spots” constituting the core of the binding interface and corroborated by additional long-time scale (300 ns) MD simulation of Arg398Ala mutant complex. A notable conformational change in Arg398Ala mutant occurred near the mutation site as compared to the equilibrated C-Raf/RKIP native state conformation and an essential hydrogen bonding interaction was lost. The thirteen binding sites assimilated from the overall analysis were mapped onto the complex as surface and divided into active and allosteric binding sites, depending on their location at the interface. The acquired information on the predicted 3D structural complex and the detected sites aid as promising targets in designing novel inhibitors to block the C-Raf/RKIP interaction.
Epidemiology of Pediatric Surgical Conditions Observed in a First-Level Hospital in Burundi
Authors: Gortan Marianna , Caravaggi Paola , Brooks Giulia , Butoyi Jean Marie Vianney , Bambara Sylvestre , Nkurunziza Joel , Mulemangabo Mimico , Nzeyimana Gordien , Harakaneza Protais , Nshimirimana Mwajuma , Tognon Costanza , Gamba Piergiorgio , Parigi Gian Battista , Dalla Gasperina Daniela 
Published: May 2021

Background: Little is known about the surgical conditions affecting the pediatric population in low-income countries. In this article we describe the epidemiology of pediatric surgical diseases observed in Mutoyi hospital, a first-level hospital in Burundi.Methods and Findings: We retrospectively reviewed the records of all children (0–14 years) admitted to the Surgery ward from January 2017 to December 2017. We also reviewed the records of all the patients admitted to the Neonatology ward in 2017 and among them we selected the ones in which a surgical diagnosis was present. Five hundred twenty-eight children were admitted to the surgical ward during the study period. The most common conditions requiring hospitalization were abscesses (29.09%), fractures (13.59%), osteomyelitis (9.76%), burns (5.40%) and head injuries (4.36%). The average length of stay was 16 days. Fifty-six newborns were admitted to the Neonatology ward for a surgical condition; 29% of them had an abscess.Conclusions: Conditions requiring surgical care are frequent in Burundian children and have a completely different spectrum from the western ones. This is due on one side to an under-diagnosis of certain conditions caused by the lack of diagnostic tools and on the other to the living conditions of the population. This difference should lead to intervention plans tailored on the actual necessities of the country and not on the western ones.
Depression and Associated Factors in Chinese Patients With Chronic Kidney Disease Without Dialysis: A Cross-Sectional Study
Authors: Duan Difei , Yang Lin , Zhang Min , Song Xiaoli , Ren Wen 
Published: May 2021

Background: Chronic kidney disease (CKD) has been a globally public health problem over the past decades. The maintenance of physical and mental health is of importance for patients nowadays. Notably, depression is prevalent and associated with various adverse events in CKD patients without dialysis. Prior studies have reported that pain, negative illness perception, pain, and low self-esteem are potential risk factors of depression, while few studies have comprehensively investigated the mechanisms among these factors and depression among this population.Purpose: This study aims to investigate the prevalence of depression and further explore the factors associated with depression among CKD patients without dialysis in China.Design and Methods: We conducted a cross-sectional study in patients with diagnosed CKD to investigate the prevalence of depression was by the Beck Depression Inventory-II (BDI-II). The data on pain interference, illness perception, and self-esteem were also collected via self-administered questionnaires. A structural equation model (SEM) was used to examine the factors associated with depression.Main Findings: From June to October 2019, we successfully interviewed 334 CKD patients at the outpatient clinics. Their mean age was 45.6 years (ranging from 19 to 74 years), and 48.5% were male. Most respondents were at early CKD stages (77.5% stage 1–3) and the prevalence of depression was 22.2%. We found a moderate association between illness perception and depression, which was modified by self-esteem. Similar but weaker association was found between pain interference and depression.Conclusion and Recommendations: Negative illness perception, low self-esteem and severe pain interference were associated with depression among Chinese CKD patients without dialysis. Future studies are warranted to investigate the underlying mechanism and formulate the intervention strategies for this high-risk population.
Patient-Reported Outcome Following Operative and Conservative Treatment of Calcaneal Fractures: A Retrospective Analysis of 79 Patients at Short- to Midterm Follow-Up
Authors: Pflüger Patrick , Zyskowski Michael , Greve Frederik , Kirchhoff Chlodwig , Biberthaler Peter , Crönlein Moritz 
Published: May 2021

Background: Fractures of the calcaneus are severe injuries of the hindfoot, mostly resulting from high-energy axial loads, which still present enormous challenges to modern trauma surgery. Possible variables influencing the outcome are the type of fracture, age, and quality of fracture reduction. These might also be factors affecting the self-reported patient outcome, but large studies are still lacking. Therefore, the aim of this study was to analyze the patient-reported outcome of calcaneal fractures following operative and conservative treatment.Methods: All patients suffering from calcaneal fractures between 2002 and 2015 were enrolled in this retrospective analysis. The calcaneal fractures were classified according to Sanders and the AO classification system. For further analysis, two groups were formed: group I involved complex intra-articular fractures defined by the involvement of the posterior calcaneal facet, while group II consisted of extra-articular and process calcaneal fractures. Data were collected via the patient registry, radiographs, and a standardized questionnaire (Foot and Ankle Outcome Score, FAOS). For outcome analysis, non-parametric Mann–Whitney U-test was performed, and Spearman's rank correlation coefficient was calculated.Results: In total, the functional outcome of 79 patients with calcaneal fractures was analyzed. In group 1 (n = 43), the mean FAOS score was 65.5 ± 18.9. The surgically treated patients with a Sanders type II calcaneal fracture had a mean FAOS score of 72.9 ± 17.2, type III fractures had 65.6 ± 20.8, and type IV had 61.1 ± 19 (p = 0.15). The reoperation rate was 22%, most frequently caused by wound complications (10%). The mean follow-up time was 64.5 ± 44 months. The mean FAOS score of group 2 (n = 36) was 75.2 ± 18.4, and 83% of the patients (=30) were managed conservatively. Only one out of six operatively managed patients had a reoperation due to regular implant removal. The mean follow-up time was 31 ± 25.9 months.Conclusion: Intra-articular calcaneal fractures are severe injuries of the hindfoot leading to a fair to poor functional outcome in the majority of the patients. Complications regarding wound healing are the most common causes for revisional surgery. Extra-articular calcaneal fractures are a heterogenous entity commonly managed non-operatively. Overall, they show a better functional outcome in comparison to intra-articular calcaneal fractures.
PELATIHAN PERSIAPAN MENGHADAPI DUNIA KERJA BAGI MAHASISWA LULUSAN BARU
Authors: Nastiti Rizky , Koroy Tri Ramaraya , Rusvitawati Devi , Krismanti Ninuk , Hermaniar Yulieda 
Published: May 2021

Semakin ketatnya persaingan kerja membuat mahasiswa yang baru lulus kuliah menghadapi kesulitan untuk mendapatkan perkerjaan yang mereka impikan. Sehingga, pembekalan diri bagi lulusan yang akan memasuki dunia kerja kini menjadi semakin penting. Oleh karena itu, pengabdian kepada masyarakat ini bertujuan untuk memberikan keterampilan bagi fresh graduate agar dapat mempersiapkan diri dengan lebih baik sebelum melamar pekerjaan. Pelatihan yang dilakukan secara daring ini menargetkan agar fresh gradute menjadi lebih siap dalam bersaing mencari pekerjaan. Pemberian materi dilakukan oleh dua orang narasumber yang kompeten, yaitu seorang psikolog yang telah berpengalaman di bidangnya dan seorang direktur utama Bank daerah. Setelah mengikuti pelatihan ini, para lulusan mendapatkan pengetahuan mengenai tips dan trik menghadapi tes wawancara dan psikotes. Sehingga, mereka menjadi lebih percaya diri dan termotivasi untuk bersaing dalam mencari pekerjaan.Kata kunci: pelatihan, dunia kerja, mahasiswa lulusan baru Increasing job competition leds the fresh graduates face difficulties in getting the job they dream of. Hence, self-provision for fresh graduates who will enter the world of work is now becoming increasingly important. Therefore, this community service aims to provide skills for fresh graduates so that they can prepare themselves better before applying for jobs. This online training aims to make the fresh gradute better prepared for job competition. The training was led by two competent speakers, an experienced psychologist and a president director of a regional bank. After attending this training, the graduates gain knowledge about tips and tricks for facing interviews and psychological tests. Thus, they become more confident and motivated to compete in job seeking.Keywords: training, world of work, fresh graduates
Management of Social Risks and their Impact on the Spheres of Human Life in the Conditions of Sustainable Development of Ukraine
Authors: Zelinska Halyna , Andrusiv Uliana , Galtsova Olga , Dmytrechenko Mykyta 
Published: May 2021

The aim of the article is to analyze risks in the social sphere and their impact on the development of society in Ukraine. Increasing the impact of risks in the sphere of demography, employment, remuneration, etc. in the context of sustainable development has been determined. The conducted research shows that the risks related to the labor sphere and the health of the population are the most aggressive and dangerous for the safety (as shown by the coronavirus pandemic) because protracted problems in the political, social and economic spheres are accompanied by job losses, economic decline, low wages for more than half of the working population. In view of the ambiguity and uneven economic development of the administrative territorial units of Ukraine it has been determined that education and knowledge can become a factor that can lead to the activation of innovative changes and reduce the negative impact of social threats. For this reason, the most important requirement for the sustainable development of Ukraine is the formulation of a social policy, based on an effective system of methods aimed at preventing risks and reducing probability of their occurrence.
A Sustainable Journey of Handmade Paper from Past to Present: A Review
Authors: Jain Prerna , Gupta Charu 
Published: May 2021

Paper is an excellent medium of expression and knowledge preservation and communication because of its writing, printing, and packaging abilities. It is a thin sheet or web-like structure made by a dilute suspension of cellulosic fibres. Handmade papermaking technology was mass accepted and considered a precious commodity before development of an industrialised wood- pulp based paper industry. This modern papermaking practice harms the environment as it uses enhanced natural resources (ample amount of water, trees as a primary source for wood pulp) and generates pollution due to release of harsh chemicals.
This paper reviews the history and process of handmade paper manufacturing from past to present. Along with that, all the pillars of sustainability (environmental, economic, and social) in relation to the handmade paper industry are deep rooted since ancient times and very much relevant for the present era of sustainable development. Various kinds of cellulosic raw materials from plants (Paper mulberry, Kazo, Gampy, hemp, bamboo, banana, etc.) and other used materials (old rags, ropes, nets, newspapers etc.) with the chemical-free production process and products make this industry eco-friendly. Craft based, small scale and labour-intensive guild art gives it social strength; whereas an infinite product range having functional and decorative uses, as well as strong export potential of the industry gives it an economic strength.
Due to the present need of sustainable production, waste minimisation, and circular economy, the handmade paper seems to very potential industry to recycle various kind of waste like weedy battles, textiles, tetra packs, currency, plastic etc. This paper is an attempt to review the journey of handmade papers, its recycling potential, various production processes, products, advantages and disadvantages of the industry from past to present.
La evaluación del aprendizaje en educación básica, una revisión desde la normatividad en México
Authors: Hernández Madrigal Pastor 
Published: May 2021

Hablar de evaluación del aprendizaje en el contexto normativo jurídico en México implica una revisión de los últimos cinco acuerdos, que permite examinar de una forma constante la complejidad de la tarea docente al momento de la evaluación del aprendizaje, a partir de una transición de la evaluación cuantitativa a integrar la evaluación cualitativa pero que al mismo tiempo se considera la política educativa, la visión social del mundo y ciertos elementos pedagógicos que permiten integrarse en el trabajo de las maestras y maestros de educación básica y sus repercusiones en las evaluaciones educativas en el país.
Cada Acuerdo Nacional sobre la Evaluación del aprendizaje responde a una necesidad social y a un régimen político que culmina en su proyección en cada escuela y aula a través de la labor pedagógica de los docentes en la formación de ciudadanos competentes, participativos y responsables para enfrentar los retos del Siglo XXI.
Perencananaan Teknis Waktu Siklus Traffic Light pada Simpang Yudhasari - Perjuangan Kota Cirebon
Authors: Hermawan Dedi , Dianasari Utami Desi 
Published: May 2021

Persimpangan merupakan simpul dalam jaringan transportasi dimana dua atau lebih ruas jalan bertemu, disini arus lalu lintas biasanya mengalami konflik. Permasalahan Simpang Yudhasari-Perjuangan adalah pertumbuhan aktivitas penduduk yang meningkat disekitarnya, ditandai dengan semakin banyaknya pemukiman-pemukiman baru, area komersil dan pendidikan yang bermunculan, menjadikan volume kendaraan di persimpangan pun ikut meningkat. Hal tersebut tidak diimbangi dengan kapasitas jalan yang tidak bertambah. Hal tersebut menjadi salah satu penyebab penelitian tentang kinerja Simpang Yudhasari-Perjuangan, meliputi waktu siklus, kapasitas, derajat kejenuhan, dan hambatan samping menggunakan metoda MKJI, 1997. Dari hasil analisis dapat disimpulkan bahwa waktu siklus yang diperlukan antara 95 sampai dengan 97 detik untuk 3 fase, sedangkan derajat kejenuhan rata-rata sebesar 0,87. Hambatan samping yang tinggi pun menjadi salah satu penyebab menurunnya kinerja simpang, terutama arah lengan Perjuangan-Majasem, untuk tipe pejalan kaki dan kendaraan keluar masuk di sekitar area simpang. Perlunya peninjuan kembali dari beberapa instansi terkait yang berkepentingan untuk masalah hambatan samping maupun arus lalu lintas, seperti penataan PKL, penataan area komersil, penataan area parkir di sekitar area simpan,. Jika dibiarkan maka kinerja simpang akan terus menurun, dan hambatan samping akan semakin tinggi.
Pengaruh Perkuliahan Daring Terhadap Efektivitas Pembelajaran Mahasiswa Program Studi Administrasi Publik Universitas Pembangunan Nasional “Veteran” Jawa Timur di Era Pandemi COVID 19
Authors: Pratama Ananta , Cahyaningrum Novia , Wulandari Ayu , Anggraini Siska Zunita 
Published: May 2021

Perkuliahan daring (online) merupakan kebijakan pemerintah yang menjadi sarana utama dalam pembelajaran ketika wabah Pandemi COVID-19. Hal ini juga diterapkan di Universitas UPN Veteran Jawa Timur yang mengikuti anjuran pemerintah untuk melakukan kegiatan daring yang menggunakan sarana aplikasi online, seperti whatsapp grup, zoom, google classroom, dan media aplikasi lain Penelitian ini bertujuan untuk menganalisis efektifitas perkuliahan daring pada mahasiswa Prodi Administrasi Publik Fakultas Ilmu Sosial dan Politik di saat Pandemi COVID-19. Penelitian ini merupakan penelitian deskriptif kuantitatif dengan menggunakan metode survey melalui google form secara online. Hasil penelitian ini diharapkan dapat mengetahui keefektifan kegiatan belajar mengajar secara daring (online) di era pandemi COVID-19. Khususnya bagi Program Studi Administrasi Publik, Fakultas Ilmu Sosial dan Ilmu Politik, UPN “Veteran” Jawa Timur.
Pengaruh Locus Of Control Terhadap Kinerja Usaha Dengan Orientasi Pasar Sebagai Variabel Moderasi
Authors: Abdullah Fahmi 
Published: May 2021

Kondisi perdagangan di pasar loak Porong setiap tahunnya mengalami peningkatan, hal ini dapt dilihat dari semakin banyaknya jumlah pedagang di pasar loak dan pada saat ini juga fasilitas berdagang juga semakin memadai. Penelitian ini bertujuan untuk mengetahui pengaruh locus of contorl terhadap kinerja usaha dan mengetahui efek moderasi orientasi pasar pada pengaruh locus of control terhadap kinerja usaha. Alat analisis untuk menguji hipotesis menggunakan SPSS 16.0 sampel dalam penelitian ini adalah 82 pedagang di pasar loak Kecamata Porong. persamaan regresi pertama pada penelitian ini sebagai berikut: Y = 1,294 + 0,671X1, hasil uji hipotesa kesatu menunjukkan hipotesis diterima, artinya locus of control berpengaruh signifikan terhadap kinerja usaha, sedangkan persamaan regresi kedua adalah Y = 3,997 + 0,310 ZX1 + 0,042 ZX2 + 0,026 AbsZX1-ZX2 untuk uji hipotesis kedua, hasilnya ditolak artinya orientasi pasar tidak mampu memoderasi pengaruh locus of control terhadap kinerja usaha, dari hasil penelitian menyebutkan bahwa orientasi pasar merupakan homologiser moderation, karena b2 dan b3 sama-sama tidak signifikan pengaruhnya.
Conductas sexuales en jóvenes mexicanos durante el confinamiento por COVID-19
Authors: Amaro-Hinojosa Marily Daniela , Jiménez-Vázquez Vicente , Juárez-Mediana Liliana Leticia , Torres-Obregon Reyna , Orozco-Gómez Claudia 
Published: May 2021

Introducción: El confinamiento por la pandemia de coronavirus (COVID-19) originó cambios en la atención a la salud sexual y reproductiva, así como en las conductas sexuales de la población. Objetivo: Describir las conductas sexuales de los jóvenes mexicanos durante el confinamiento por COVID-19. Metodología: Diseño descriptivo transversal, se conformó la muestra por 613 jóvenes de 18 a 28 años de México, el muestreo fue no probabilístico por conveniencia, se realizó una encuesta en línea. Se aplicó una cédula de datos y un cuestionario de conductas sexuales adaptado para este estudio. El análisis de los datos se realizó en el paquete estadístico SPSS versión 25, a través de estadística descriptiva e inferencial como fue la prueba t de Student. Resultados: Las principales conductas encontradas durante el confinamiento por coronavirus fueron: la masturbación 49.9%, ver pornografía 43.2%, sexting 33.9%, cibersexo 17.9% y tener sexo oral, vaginal y/o anal en 46.8%. Conclusiones: La conducta sexual de los jóvenes se modificó durante el confinamiento comparado con el último año. Estos hallazgos brindan evidencia para el desarrollo de intervenciones de Enfermería para la promoción de la salud sexual ante situaciones de crisis en salud como lo es el COVID-19.
Fatalismo y estrés percibido relacionado con la pandemia de COVID-19 de los profesionales de enfermería
Authors: Maldonado-Muñiz Gabriela , Trejo-García Claudia Atala , Gerrero-García Adriana , Mendoza-Benítez Irene 
Published: May 2021

Introducción: El profesional de enfermería es primordial para afrontar la pandemia de COVID-19, los cambios en la organización de trabajo y la vulnerabilidad pueden estar relacionados con el fatalismo y estrés percibido, respuesta neurológica que impacta en la calidad de vida de las personas. Objetivo: Analizar el nivel de fatalismo y estrés percibido relacionado con la pandemia COVID-19 de los profesionales de enfermería. Metodología: Estudio tipo cuantitativo, alcance correlacional, diseño observacional, transversal. Muestra de 551 profesionales de Enfermería del estado de Hidalgo, no probabilística, se incluyó a profesionales que laboraban en los tres niveles de atención, que aceptaron participar y con acceso a internet; posterior al asentimiento informado se aplicaron la escala de fatalismo relacionado con COVID-19 y la escala de estrés percibido relacionado con la pandemia, a través un formulario de Google Drive. El análisis estadístico fue realizado con SPSS versión 24. Resultados: edad media de 34.46±9.4 años, 89% mujeres, 68% con nivel Licenciatura, prevaleció la religión católica con 84.2%. 3.1 % de la muestra mostró nivel de estrés alto, 59.9% medio y 37% bajo; 61% evidenció fatalismo ausente ante la posibilidad de contagio por el Coronavirus y 39% presente. El análisis correlacional mostró que el nivel de estrés y el fatalismo obteniendo Rho=-.236 con una correlación negativa nula. Conclusión: No existe una relación significativa entre el fatalismo y el nivel de estrés percibido relacionado con la pandemia de COVID-19 de los profesionales de enfermería.