bluuebunny/crossref_metadata_2025_split huggingface dataset:
A search for variable subdwarf B stars in TESS Full Frame Images – II. Variable objects in the northern ecliptic hemisphere
Authors: Baran A S , Sahoo S K , Sanjayan S , Ostrowski J 
Published: March 2021

ABSTRACT
We report the results of our search for pulsating subdwarf B stars in Full Frame Images collected during Year 2 of the TESS mission and covering the northern ecliptic hemisphere. This is a continuation of our effort we presented in Paper I. We found 13 likely new pulsating subdwarf B stars, 10 pulsating candidates that are identified as other hot subdwarfs, and 30 spectroscopically unclassified objects that show amplitude spectra typical of pulsating subdwarf B stars. We found 506 variable objects, most of them spectroscopically unclassified, hence their specific variability class yet to be confirmed. Eclipsing binaries with sharp eclipses sample comprises 33 systems. For 12 of them we derived precise orbital periods and checked their stabilities. We identified one known and five new candidate HW Vir systems. The amplitude spectra of the 13 likely sdB pulsators are not rich in modes, hence any further analysis is not possible. However, we selected three candidates for pulsating subdwarf B stars that show the richest amplitude spectra and we performed a mode identification deriving modal degrees of most of the detected modes. In total, in both ecliptic hemispheres, we found 15 likely pulsating pulsating subdwarf B stars, additional 10 candidates for pulsating subdwarf B stars, 66 other variable subdwarf B stars, 2076 spectroscopically unconfirmed variable stars, and 123 variable non-sdB stars.
Investigating the projected phase space of Gaussian and non-Gaussian clusters
Authors: Sampaio V M , de Carvalho R R , Ferreras I , Laganá T F , Ribeiro A L B , Rembold S B 
Published: March 2021

ABSTRACT
By way of the projected phase space (PPS), we investigate the relation between galaxy properties and cluster environment in a subsample of groups from the Yang catalogue. The sample is split according to the Gaussianity of the velocity distribution in the group into Gaussian (G) and non-Gaussian (NG). Our sample is limited to massive clusters with $\rm \mathit{ M}_{200} \ge 10^{14}\, M_{\odot }$ and $\rm 0.03\le \mathit{ z} \le 0.1$. NG clusters are more massive, less concentrated and have an excess of faint (F) galaxies compared to G clusters. NG clusters show mixed distributions of galaxy properties in the PPS compared to the G case. Using the relation between infall time and locus on the PPS, we find that, on average, NG clusters accreted ${\sim}\rm 10^{11}\, M_{\odot }$ more stellar mass in the last ∼5 Gyr than G clusters. The relation between galaxy properties and infall time is significantly different for galaxies in G and NG systems. The more mixed distribution in the PPS of NG clusters translates into shallower relations with infall time. F galaxies whose first crossing of the cluster virial radius happened 2–4 Gyr ago in NG clusters are older and more metal-rich than in G systems. All these results suggest that NG clusters experience a higher accretion of pre-processed galaxies, which characterizes G and NG clusters as different environments to study galaxy evolution.
Recommendations for the use of COVID-19 vaccines in patients with immune-mediated kidney diseases
Authors: Kronbichler Andreas , Anders Hans-Joachim , Fernandez-Juárez Gema Maria , Floege Jürgen , Goumenos Dimitrios , Segelmark Mårten , Tesar Vladimir , Turkmen Kultigin , van Kooten Cees , Bruchfeld Annette ,   the Immunonephrology Working Group of the ERA-EDTA (European Renal Association—European Dialysis and Transplant Association)
Published: March 2021

Abstract

Coronavirus disease 2019 (COVID-19) vaccine platforms are becoming available and are the most promising strategy to curb the spread of severe acute respiratory syndrome coronavirus 2 infections. However, numerous uncertainties exist regarding the pros and cons of vaccination, especially in patients with (immune-mediated) kidney diseases on immunosuppressive drugs. Here, members of the Immunonephrology Working Group of the European Renal Association–European Dialysis and Transplant Association discuss 13 frequently asked questions regarding the safety and efficacy of the most promising vaccine candidates. Post-marketing surveillance should be performed to estimate the rate of vaccine response (humoral and cellular) of different vaccine platforms and disease activity following the administration of COVID-19 vaccines. Some of the candidates induce signalling pathways, which also promote autoimmune kidney diseases, e.g. type I interferons in systemic lupus erythematosus. Efficacy estimates would thus far favour the use of selected COVID-19 vaccines, such as BNT162b2, mRNA-1273 or Gam-COVID-Vac. Humoral immune response after vaccination should be monitored using appropriate assays. Even in the absence of neutralizing antibodies, patients might be protected by a sufficient cellular immune response capable of reducing the severity of COVID-19. A reduced vaccine response after the use of CD20-depleting agents is anticipated and it is particularly important to discuss strategies to improve vaccine response with these patients. Distancing and shielding measures remain important, as not all vaccines fully protect from coronavirus infection. In-depth information about the most pressing vaccine questions is essential to reduce vaccine hesitancy of patients.
Patterns of Non-Cigarette Tobacco and Nicotine Use Among Current Cigarette Smokers and Recent Quitters: Findings From the 2020 ITC Four Country Smoking and Vaping Survey
Authors: Li Lin , Borland Ron , Cummings K Michael , Gravely Shannon , Quah Anne C K , Fong Geoffrey T , Miller Connor R , Goniewicz Maciej L , Le Grande Michael , McNeill Ann 
Published: March 2021

Abstract

Introduction
This study explores patterns of use of non-cigarette tobacco and nicotine products among adult cigarette smokers and recent ex-smokers. Along with cigarette smoking status we explore differences as a function of countries with different product regulations, gender, and age.

Methods
Data came from the ITC Four Country Smoking and Vaping Wave 3 Survey conducted between February–June 2020. The analytic sample consisted of 9112 current cigarette smokers (at least monthly) and 1184 recent ex-smokers (quit cigarettes ≤ 2 years) from Australia, Canada, England, and the United States. Respondents were asked about their cigarette smoking and current use of the following non-cigarette products: combustible tobacco (cigars, cigarillos, pipe, waterpipe); noncombustible tobacco (smokeless tobacco, and heated tobacco products [HTPs]); and non-tobacco nicotine products (nicotine vaping products [NVPs], nicotine replacement therapy [NRT], and nicotine pouches).

Results
Overall, NVPs (13.7%) and NRT (10.9%) were the most reported nicotine products used, followed by cigars (5.3%), cigarillos (4.2%), and HTPs (3.5%). More than 21% current and recent ex-smokers of cigarettes reported using a non-tobacco nicotine product and noncombustible product, with respondents in England reporting the highest levels of use (&gt;26%). Males, younger respondents, and current non-daily cigarette smokers were more likely to use non-cigarette nicotine products. Notably, 11.6% of ex-cigarette smokers were using other combustible tobacco.

Conclusion
Considerable percentages of current cigarette smokers and ex-smokers use non-cigarette nicotine products, and there are unexpectedly high levels of use of other combustible products by those recent ex-smokers of cigarettes which is concerning and has important implications for definitions of smoking cessation.

Implications
The tobacco product market has evolved to include new products which add to existing non-cigarette tobacco products creating a much more diverse nicotine market. This brief report provides a snapshot of use of various combustible and noncombustible nicotine-containing products among current cigarette smokers and recent ex-smokers in four western countries. Our results indicate that use of non-cigarette tobacco and nicotine products among these cigarette smokers and recent ex-smokers is not low, particularly among males, younger and non-daily cigarette smokers. Use of other combustible tobacco among respondents that recently quit cigarette smoking is concerning and has important implications for definitions of smoking cessation. Increased emphasis on researching non-cigarette nicotine product use is warranted in tobacco control generally and smoking cessation in particular.
Efficacy and Tolerability of Calcitonin Gene–Related Peptide–Targeted Monoclonal Antibody Medications as Add-on Therapy to OnabotulinumtoxinA in Patients with Chronic Migraine
Authors: Cohen Fred , Armand Cynthia , Lipton Richard B , Vollbracht Sarah 
Published: March 2021

Abstract

Background
We examined the efficacy and tolerability of calcitonin gene–related peptide–targeted monoclonal antibodies (CGRP-targeted mAbs) as add-on therapy for patients with chronic migraine (CM) undergoing treatment with onabotulinumtoxinA (onabot) who require additional preventive therapy.

Methods
We reviewed medical records of patients with CM receiving treatment with onabot who were subsequently prescribed a CGRP-targeted mAb medication. The primary outcome was the change in number of monthly headache days (MHDs) reported. Secondary outcomes were change in headache pain severity, discontinuation due to lack of tolerability, and severe adverse events.

Results
Of 153 patients, 111 (72.5%) reported a decrease in either MHDs or headache pain severity, with documentation of MHDs in 66 patients. Among these 66 patients, the average number of MHDs before initiation of onabot treatment was 25.7. After onabot treatment, an average decrease of 10.9 MHDs was reported (P &lt; 0.001). After the addition of a CGRP-targeted mAb medication, patients experienced a further decrease of 5.7 MHDs (P &lt; 0.001). With combined therapy, patients reported a total decrease of 16.6 MHDs (P &lt; 0.001). Adverse effects occurred in 13 patients (8.5%) after addition of the CGRP-targeted mAb and included constipation, injection site reaction, and fatigue. No serious adverse events were reported.

Conclusion
Adding a CGRP-targeted mAb to onabot in patients with CM was associated with further reductions in MHDs without major tolerability issues across a range of mAbs. This retrospective review supports the conduct of a well-designed double-blind study adding a CGRP-targeted mAb or placebo to onabot.
Real-life analysis of the causes of death in patients consecutively followed for giant cell arteritis in a French centre of expertise
Authors: Antonini Luca , Dumont Anael , Lavergne Amandine , Castan Paul , Barakat Clivia , Gallou Sophie , Sultan Audrey , Deshayes Samuel , Aouba Achille , de Boysson Hubert 
Published: March 2021

Abstract

Objectives
To describe, in a real-life setting, the direct causes of death in a cohort of consecutive patients with GCA.

Methods
We retrospectively analysed the deaths that occurred in a cohort of 470 consecutive GCA patients from a centre of expertise between January 2000 and December 2019. Among the 120 patients who died, we retrieved data from the medical files of 101 patients.

Results
Cardiovascular events were the dominant cause of death (n = 41, 41%) followed by infections (n = 22, 22%), geriatric situations (i.e. falls or senile deterioration; n = 17, 17%) and cancers (n = 15, 15%). Patients in each of these four groups were compared with the other deceased patients pooled together. Patients who died from cardiovascular events were more frequently male (46 vs 27%; P = 0.04) with a past history of coronary artery disease (29 vs 8%; P = 0.006). Patients who died from infections mostly had ongoing glucocorticoid treatment (82 vs 53%; P = 0.02) with higher cumulative doses (13 994 vs 9150 mg; P = 0.03). Patients who died from geriatric causes more frequently had osteoporosis (56 vs 17%; P = 0.0009) and had mostly discontinued glucocorticoid treatment (76 vs 33%; P = 0.001). The predictive factors of death in multivariate analysis were a history of coronary disease [hazard ratio (HR) 2.39; 95% CI 1.27, 4.21; P = 0.008], strokes at GCA diagnosis (HR 2.54; 95% CI 1.05, 5.24; P = 0.04), any infection during follow-up (HR 1.93; 95% CI 1.24, 2.98; P = 0.004) and fever at GCA diagnosis (HR 1.99; 95% CI 1.16, 3.28; P = 0.01).

Conclusion
Our study provides real-life insight on the cause-specific mortality in GCA patients.
Differences in intestinal microbiota profiling after upper and lower gastrointestinal surgery
Authors: Lin Xi-Hsuan , Yang Ueng-Cheng , Luo Jiing-Chyuan , Chang Tien-En , Lin Hung-Hsin , Huang Chi-Wei , Chiou Jen-Jie , Fang Wen-Liang , Huang Kuo-Hung , Huang Yi-Hsiang , Hou Ming-Chih , Lee Fa-Yauh 
Published: March 2021

Background:
We aimed to investigate the long-term effects of metabolic profiles and microbiota status in patients after upper gastrointestinal (GI) surgery and lower GI surgery and compared them with a control group.

Methods:
In this cross-sectional study, we analyzed the occurrence of metabolic syndrome (MS) in 10 patients who underwent curative total gastrectomy with Roux-en-Y esophagojejunostomy (RYEJ) anastomosis, 11 patients who underwent curative partial colectomy with right hemicolectomy (RH), and 33 age- and sex-matched controls. Fecal samples were also analyzed by a next-generation sequencing method.

Results:
Compared with the control group, the occurrence of MS was significantly lower among patients who underwent total gastrectomy with RYEJ than the controls over the long-term follow-up (>8 years; p < 0.05). Patients who received RH only had a trend of higher serum fasting glucose (p = 0.10). The diversity of the gut microbiota significantly decreased after RH in comparison with the control group and RYEJ group, respectively (p < 0.05). Principal component analysis revealed significant differences between the control, RYEJ, and RH groups (p < 0.001). At the genus level, the ratio of Prevotella to Bacteroides (P/B) was significantly higher in the RYEJ group than in the control group, whereas the P/B ratio was significantly lower in the RH group than in the control group (p < 0.05).

Conclusion:
Early gastric cancer patients who received total gastrectomy with RYEJ had a lower occurrence of MS than the controls, while early colorectal cancer patients who received RH were associated with a higher serum fasting glucose than the controls during long-term follow-up. In parallel with the metabolic differences, the P/B ratio was also significantly altered in patients after upper and lower GI surgery.
Predicting Schwannoma Growth in a Tumor Model Using Targeted Imaging
Authors: Morrison Daniel R. , Sorace Anna G. , Hamilton Ellis , Moore Lindsay S. , Houson Hailey A. , Udayakumar Neha , Ovaitt Alyssa , Warram Jason M. , Walsh Erika M. 
Published: March 2021

Introduction:
Vestibular schwannoma (VS) is a common pathology encountered in neurotology clinics. Many patients are observed with a “wait and scan” approach. Previous efforts to determine radiographic indicators of future growth have been unsuccessful. Using a mouse subcutaneous tumor model, we seek to determine if fluorescent imaging with directed immunotargets could be used to predict schwannoma growth rate.

Methods:
Anti-VEGFR2 and anti-Her2/Neu monoclonal antibodies were covalently linked to a near-infrared probe (IRDye800). Immunodeficient mice underwent subcutaneous injections with a rat-derived schwann (R3) cell line. When tumor growth was evident, either Anti-VEGFR2-IRDye800, anti-Her2/Neu-IRDye800, or Immunoglobulin G (IgG) Isotype-IRDye800 (control) were injected via tail vein. The mice were serially imaged in a closed field near-IR device. Fluorescent data were analyzed for tumor signal and correlated with tumor sie and growth rate. Heterogeneity of fluorescent tumor signal was also assessed.

Results:
In both anti-VEGFR2 and anti-Her2/Neu groups, there were strong correlations between day 1 mean tumor fluorescence and eventual maximum tumor volume (p = 0.002, 0.001; r
2 = 0.92, 0.86). There was also strong correlation with maximum tumor signal on day 1 and maximum tumor volume (p = 0.003, 0.008; r
2 = 0.90, 0.91). There was no such correlation in the control group (p = 0.99, 0.75; r
2 = 0.0002, 0.028).

Conclusion:
Given the potential morbidity in VS intervention, observation is an appropriate approach for patients with slow-growing or stagnant tumors. We seek to identify immunotargets in a murine model that show promise in predicting schwannoma growth with advanced imaging techniques. Both Her2/Neu and VEGFR2 correlated strongly wth tumor size and growth rates and are promising targets that merit further investigation.
Delirium caused by topical administration of cyclopentolate for cataract surgery in mild cognitive impairment due to Alzheimer's disease
Authors: Shin Yu Yong , Lee Jin San , Park Key-Chung , Rhee Hak Young 
Published: March 2021

Abstract

Rationales:
Cholinergic modification by anticholinergic medication can produce adverse effects in central nervous system (CNS) and cyclopentolate is an antimuscarinic agent widely used for ophthalmologic management. We demonstrate a rare case of hyperactive delirium caused by topical administration of cyclopentolate in a patient with amnestic mild cognitive impairment (MCI) due to Alzheimer's disease (AD).

Patient concerns:
A 74-year-old man showed acute confusion after preparation for cataract operation in day surgery clinic. The patient became confused and agitated after instillation of topical cyclopentolate drop into the eye and the symptoms persisted over several hours.

Diagnosis:
Previously the patient had been diagnosed with amnestic MCI with the finding of bilateral medial temporal atrophy on brain magnetic resonance imaging. 18F-flutemetamol positron emission tomography scan demonstrated multifocal amyloid deposition in the brain.

Interventions:
The patient was closely observed with the supportive management.

Outcomes:
The patient began to recover 5 h after the onset of symptoms and the cognitive function was reverted to previous state within 24 h.

Lessons:
It is well known that several drugs with anticholinergic effects used in perioperative periods make the patients susceptible to delirium, but even the topical administration of cyclopentolate for cataract surgery also produce adverse CNS effects in a vulnerable patient who is diagnosed with MCI due to AD in this case.
The impact of COVID-19 on sexual behaviors of young women and men
Authors: Zhang Qi , Lu Hua , Li Fangyuan , Li Xinyun , Wang Tong , Yang Qian , Mi Ling 
Published: March 2021

Abstract

Background:
The worldwide impact of COVID-19 has reached all spheres of human health. Individuals may also experience unique changes in their sexual behaviors during the COVID-19 self-isolation/social distancing period. Studies in many countries have assess the effects of the pandemic on sexual behavior, or quality of sexual life. However, no systematic review has comprehensively explored the association between COVID-19 and the sexual behaviors of young women and men to date. This systematic review and meta-analysis protocol aims to ascertain the association between COVID-19 and sexual behaviors of young women and men that may get targeted interventions to improve health and well-being of young people's sexual health.

Methods:
This systematic review and meta-analysis will be reported following the PRISMA guidelines. Observational designs (including cross-sectional, case-control, and cohort) will be eligible. Studies eligible for inclusion must contain participants aged 15 to 45 in any country affected by the pandemic of COVID-19. The search will be conducted in the following databases, including PubMed, Cochrane Library, EMBASE, EBSCO, Ovid, WHO COVID-19 database, China National Knowledge Internet (CNKI), WanFang Data, Chinese Scientific and Technological Journal Database (VIP), and Chinese Biomedical Databases (CBM). A pre-designed search strategy of medical subject heading (MeSH) terms and free words for the concepts “COVID-19” and “sexual behaviors” will be used. Two authors will independently complete literature screening, data extraction, and risk of bias assessment. Disagreements will be resolved by consensus with a third reviewer. The reviewer will follow the PECOS steps (population, exposure, comparator, outcomes, and study design) to obtain eligible extraction items. The risk of bias and quality of included studies will be assessed using RevMan 5.3. We will assess heterogeneity according to the I
2 statistics. If there is substantial heterogeneity in the included trials, subgroup analysis will be carried out to seek the potential causes.

Ethics and dissemination:
It is not necessary to obtain ethical approval as we will use data from published articles. The findings of this systematic review will be published in a peer- reviewed journal.

PROSPERO registration number:
PROSPERO 2020: CRD42020190867.
Self-perception of theoretical knowledges and practical skills by primary health care physicians in life-threatening emergencies according to their gender
Authors: Cernuda Martínez José Antonio , Castro Delgado Rafael , Arcos González Pedro 
Published: March 2021

Abstract
To assess the training received in Emergency Medicine (EM) by the Primary Health Care physicians of Asturias, as well as their perception of their own theoretical knowledge and practical skills in a series of procedures employed in life-threatening emergencies, and also to analyze the differences according to gender. The degree of preparation of Primary Health Care physicians for handling emergencies, according to the gender of the professionals, has never been studied before.
Cross-sectional study of a sample of 213 Primary Health Care physicians from the Primary Health Care Service of Asturias, Spain, from among the total of 851 physicians on the staff of the Primary Health Care Service of Asturias. The survey was design ad hoc using the Body of Doctrine of Emergency Medicine proposed by the Spanish Society of Emergency Medicine, which indicates the theoretical and practical procedures that must be mastered by the Primary Health Care physicians.
There are nonsignificant differences in the mean of theoretical knowledge and practical skills in many procedures or techniques studied depending on the gender.
Female and male Asturian Primary Health Care physicians are generally well prepared to handle life-threatening emergencies. The degree of self-perception and acquisition of general theoretical knowledge and general practical skills for handling life-threatening emergencies is heterogeneous, and differences according to gender are not statistically significant.