bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Skin Incisional Wound Healing With Intracellular ATP Delivery via Macrophage Proliferation and Direct Collagen Production
Authors: Sarojini Harshini , Bajorek Alexander , Wan Rong , Wang Jianpu , Zhang Qunwei , Billeter Adrian T. , Chien Sufan 
Published: June 2021

This study sought to use a newly developed intracellular ATP delivery to enhance incisional wound healing to reduce surgical wound dehiscence and to explore possible mechanism for this effect. Thirty-five adult New Zealand white rabbits were used. Skin incisions were made on the back and closed. ATP-vesicles were mixed with a neutral cream for one side of the wounds while the neutral cream alone was used on the other side of the wounds. Laser speckle contrast imaging (LSCI), biomechanical, histological, and immunohistochemical analyses were performed 7 and 14 days after surgery, and macrophage culture was used to test the enhanced collagen production ability. Among them, 10 were used for wound perfusion study and 25 were used for wound biomechanical and histological/immunohistochemical studies. Wound tissue perfusion was reduced after surgery especially in early days. Wound tissue tensile strength, breaking stress, and elasticity were all much higher in the ATP-vesicle treated group than in the cream treated group at days 7 and 14. The healing was complemented by earlier macrophage accumulation, in situ proliferation, followed by direct collagen production. The results were further confirmed by human macrophage culture. It was concluded that intracellular ATP delivery enhanced healing strength of incisional wounds via multiple mechanisms.
Prevalence and Characteristics of Social Withdrawal Tendency Among 3–24 Months in China: A Pilot Study
Authors: Zhou Fengjuan , Huang Peiyuan , Wei Xueling , Guo Yixin , Lu Jinhua , Feng Lanlan , Lu Minshan , Liu Xian , Tu Si , Deprez Alexandra , Guedeney Antoine , Shen Songying , Qiu Xiu 
Published: June 2021

Background: Sustained withdrawal behavior is an obstacle for child development. The present study aimed to preliminarily evaluate the prevalence of social withdrawal tendency in young Chinese children using the Alarm Distress Baby Scale (ADBB) and describe the characteristics of socially withdrawn children.Method: This was a cross-sectional analysis as part of a prospective cohort study. A total of 114 children aged 3–24 months were included. The following instruments were administered: the Chinese version of ADBB, the Ages and Stages Questionnaire (ASQ-3), the Ages and Stages Questionnaire: Social-Emotional (ASQ:SE), and the Infant Temperamental Questionnaire. The tendency of social withdrawal in children was assessed using the ADBB. Social withdrawal was defined as an ADBB score of 5 or above. Student's t-test, χ2 test, and Fisher's exact test were performed to identify the differences in maternal and child characteristics between the children with and without social withdrawal. Age-specific indicators of development in these two groups were also presented.Results: About 16.7% of the children were socially withdrawn. Compared with those without social withdrawal, children with social withdrawal were older and had higher proportions of boys (68.4 vs. 42.1%) and social-emotional development delay (63.2 vs. 0%). In age-specific analyses, social-emotional development was poorer in children with social withdrawal across all age groups from 3 to 24 months.Conclusion: Assessed by the ADBB, the prevalence of social withdrawal tendency in young Chinese children was similar to that reported in the European population; children with social withdrawal tended to have poorer social-emotional development. Further research with larger sample sizes is needed to validate the scale and confirm these findings.
From Learning to Memory: A Comparison Between Verbal and Non-verbal Skills in 22q11.2 Deletion Syndrome
Authors: Maeder Johanna , Bostelmann Mathilde , Schneider Maude , Bortolin Karin , Kliegel Matthias , Eliez Stephan 
Published: June 2021

Background: Previous studies on possible memory deficits in 22q11DS often focused on quantifying the information memorized, whereas learning processes have been mostly overlooked. Furthermore, methodological differences in task design have made verbal and non-verbal comparison challenging and mixed results have been observed depending on chosen stimuli.Method: 135 participants (78 with 22q11DS) completed a multi-trial memory task modeled after the Rey Auditory Verbal Learning Task, comparing verbal and non-verbal learning as well as retention over time. Performance in the 22q11DS group were compared to controls and learning curves were analyzed.Results: In 22q11DS, slower acquisition of non-verbal material and higher rates of errors in both verbal and non-verbal tasks was observed. After 30 min, free recall performance, when corrected for initial learning rate, was similar between 22q11DS and controls. Conversely, recognition performance was overall weaker for 22q11DS in both modalities (verbal and non-verbal).Conclusion: This study examined how information is acquired, retained in memory over time and how different recall modalities (free recall vs. recognition) could yield different performances. Clinical implications of the findings are discussed.
MITIGATION AND AGGRAVATION OF IMPOSITION IN RUSSIAN-LANGUAGE UNIVERSITY PROSE (IN I. GREKOVA "DEPARTMENT")
Authors: Заболотнева О.Л. , Кожухова И.В. 
Published: June 2021

Постановка задачи. На материале университетской повести И. Грековой «Кафедра» рассматриваются продуктивные способы реализации категории аггравации импозитивности в разно- и равностатусной коммуникации, институциональном и неинституциональном общении. Коммуникативная импозитивность традиционно ассоциируется с угрозой позитивному лицу говорящего. Необходимость данного исследования обусловлена, во-первых, слабой изученностью жанра с точки зрения прагматики, а во-вторых, - выявлением лингвопрагматических особенностей, характеристики которых можно проследить в художественном дискурсе (например, авторские ремарки). Результаты. Описаны результаты анализа университетской повести И. Грековой, иллюстрирующие широкое употребление вопросительных по форме высказываний. Импозитивность данных высказываний определяется контекстуально-усилительными элементами, интенсификаторами, разговорной, оценочной и эмоциональной лексикой с отрицательной коннотацией. Подобные элементы иллюстрируют определенную элитарность и надменность коммуникантов (особенно при равностатусном общении). Частотным является использование вопросительных по форме высказываний, модифицированных частицами а, же, ну, -ка. Кроме того, рассмотрены элементы просодии и эмфатической пунктуации. Выводы. Проведенные наблюдения позволяют увидеть продуктивные средства реализации аггравации импозитивности в русскоязычной университетской прозе.
Problem statement. On the basis of the university novel "Department" written by I. Grekova, the productive ways of realization of the category of aggravation of imposition in different and equal status communication as well as institutional and non-institutional communication are considered. Communicative imposition is traditionally associated with a threat to the positive face of a speaker. The need for this research is caused by, firstly, the poor study of the genre in terms of pragmatics, and secondly - the identification of linguistic and pragmatic features, the characteristics of which can be traced in fiction discourse (eg, author's remarks). Results. The results of the analysis of I. Grekova's university novel are described in the article. They illustrate a wide usage of interrogative statements. The imposition of these statements is defined with the help of contextual-amplifying elements, intensifiers, colloquial, evaluative and emotional vocabulary with negative connotation. Such elements illustrate a certain elitism and arrogance of communicants (especially in equal communication). Frequent is the use of interrogative statements modified by the particles and, but, well, just . Besides, elements of prosody and emphatic punctuation are considered. Conclusion. The conducted observations allow us to see the productive means of realization of the aggravation of imposition in Russian university prose.
Types of Incentives and Advertisements in Commercial Deals, A Research Study in the Light of Shariah.
Authors: Kouser Hafiza Humaria , Lakhvi Dr. Muhammad Hammad 
Published: June 2021

Wherever person goes, he finds unless it finds advertisement tools in various shapes and sizes. These ads, which have become an important pattern in the life of traders are indispensable for them than in contemporary reality. But now companies are specializing in the production of these ads and incentives, taking advantage of all the modern means of magazines and broadcasting video and audio formats and even mobile internet services. Each of these companies have their own philosophy of it, some of which consider the legitimate controls in advertisements but other are to make money regardless of the appropriateness of these ads or following the controls of legitimacy and this research aims at highlighting the most important of these Islamic perspective controls which must be adhered when designing these commercials ads. Islam regulates the trade system and provides a sound guideline to its followers. It has forbidden all the malpractices being exercised in business and its advertisement. The research talks about the commercial advertisements, their types, aims and the opinions of Islamic experts about them. Besides, the research proves that advertisement is permissible according to shariah.
Subjects about Admonition and Wisdom in the Poetry of Imam Muhammad Bin Idris Shafe'i
Authors: Azhar Dr. Muhammad Munir , Ismail Dr. Muhammad Saleem 
Published: June 2021

Im?m Al Sh?f? has great contribution towards grammatical and principled Arabic poetry. It is observed that his poetry is rich with ethical values. He gained his reputation at the same time as a Muslim jurist and a great man of wisdom. He is the writer of many books regarding Islamic jurisprudence, and a famous book of poetry “Deewan e Sh?f?.” More over his books contain such ethical values in couplet mood. All of these discussed values, he truly abstracted and retrieved from the holy Quran and hadith. This article presents a special study regarding his valuable topics of ethics. The article is a comprehensive study of the ethical values found in the poetry of Al imam Al-Sh?f?. The important ethical values of his poetry are: true advice of Muslim and knowledge positively. He also discussed some bad habits to aware the people about their bad impacts on nature and gives examples of their destructions in human beings. Some of them are fraud, cruelty and being the secretary of the ruler etc. He also discussed some bad habits to aware the people about their bad impacts on nature and gives examples of their destructions in human beings. Some of them are fraud, cruelty and being the secretary of the ruler etc.
Aproximación teórica de las necesidades del hombre y su relación con la configuración de la vivienda, el imaginario y la ciudad
Authors: Garcia Luz Marcela , Cotera Elizondo Pablo , Gallegos Medina Martín Francisco 
Published: June 2021

La actual configuración de la ciudad, de la vivienda y la forma en que se conciben los imaginarios, condicionan el cumplimento de las necesidades esenciales del hombre, debido a la ideología mercantilista predominante, que subyuga al hombre a escenarios semejantes a los mencionados en el mito del lecho de Procusto, para imponer en aras una uniformidad de espacios insalubres.
El método a seguir en este capítulo es conceptual analítico deductivo y descriptivo, analizando información sobre el fenómeno vivienda, imaginarios y ciudad. Es, además un trabajo de carácter interdisciplinario. El enfoque descriptivo permitirá vincular las necesidades del hombre, partiendo de la teoría de Maslow con una implicación directa o indirecta en el bienestar del hombre, además, para agregar un hilo conductor a este artículo se tomarán recursos del método narrativo para la investigación.
El objetivo de este escrito es hacer un análisis entre las necesidades del hombre, y la configuración contemporánea de las ciudades, las viviendas, y en su carácter dentro de los imaginarios, con el fin de analizar las posibles vinculaciones con el bienestar.
Causes and Effects of Absenteeism among First Year College Students of the Mindanao State University – Sulu
Authors: Lukman Adamel K. 
Published: June 2021

One of the major barriers to learning faced by the students and teachers in schools today is lack of consistent attendance. Poor student attendance has a far-reaching effect on the individual student especially on their academic performance in the school. This problem is caused by this major perennial problem—absenteeism. Absenteeism is a chronic absence in nature. It is habitual failure to attend school. When students regularly miss out classes consistently would entail disadvantages academically. However, the main purpose of this study was to identify the causes and effects of absenteeism among first year college students of the Mindanao State University-Sulu, as well as to determine and figure out possible remedies to address this problem. In analyzing and computing the data, the researcher used SPSS version 21.0, and utilized checklist questionnaire and an open-ended questionnaire, respondents were consisted of 100 first year college students and 9 faculty members the researcher was able to find out the leading cause of absenteeism among the first year college students of MSU-Sulu and that is ‘school is far from home’ with (3.06) mean value . While low grade point average (GPA) with mean value (3.78) was the leading effect of absenteeism followed by poor critical thinking skills, other effects of absenteeism were, poor classroom performance, low examination results, poor oral recitation, poor creative skills, poor communication skills, lack of self-confidence, low comprehension and high risk of dropouts. The researcher was able to figure out remedies that can be applied to address the problem on absenteeism. The remedies include (a) there must be a student dormitory inside the campus to house the students since majority of the students enrolled in the university are from distant island municipalities (b) conduct orientation to students and parents prior to the opening of regular classes (c) the university must have a strict policy dealing with students’ absenteeism (d) teacher or instructor should conduct regular assessment in the form of quiz at the end of the session (e) motivate and encourage the students to give more attention and emphasize the importance of education in their future (f) classroom atmosphere should be conducive to learning.
Comparative Analysis of Mast Cell Density in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma
Authors: Nandita K.P  , Srikant N  , Karen Boaz  , Amitha J Lewis  , Nidhi Manaktala  
Published: June 2021

Introduction: Oral squamous cell carcinoma (OSCC) is one of the most common malignancies of the oral cavity. One of the foremost cells recruited near the tumor front is the mast cells. Mast cells produce angiogenic mediators such as fibroblast growth factor (FGF), transforming growth factor (TGF), tumor necrosis factor, (TNF), and the vascular endothelial growth factor (VEGF) 1. which are increased in precancerous lesions and found in more abundance in OSCC.Accumulation of mast cells around the tumor margins and their release of potent pro-angiogenic and angiogenic factors may represent a tumor-host interaction which probably favors tumor progression. The progression of oral lesions from dysplasia to oral squamous cell carcinoma is characterized by an “angiogenic switch” that is associated with an increase in the neovascularization of the subepithelial lamina propria, which may be considered an indicator of malignant transformation. 2MCs also represent a rich source of proteases, especially ofmast cell tryptase and chymase, which directly degrade the extracellularmatrix through their proteolytic activity and thus indirectly stimulate angiogenesis and facilitate invasion and metastasis. Theliterature has proven that mast cells can be an indicator of increased angiogenesis and hence can help in the prediction of carcinogenesis, its progression, and also the prognosis of the malignant lesions.Aim of the Study: To compare the number, morphology, and distribution of mast cells in different grades of oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) and to study their role in tumor growth and pathogenesisMaterials and Methods: A total of 39 cases, which included 13 cases of dysplasia and 26 of OSCC were included in the study. Tissue sections were stained with H&E and 1% toluidine blue was used to evaluate mast cells. Mast cells were counted manually using an ocular grid throughout the tissue sections in 10 representative grid fields in a stepladder fashion. (40x magnification).The mean mast cell density (MCD) of 10 fields was calculated and was expressed as mean (standard deviation) per mm3,4. Mast cells were then categorized as typical, atypical, or granular mast cells and statistically analyzed.5Result: In the present study, there is a decrease in the number of mast cells with severe grades of dysplasia and poorer grades of oral squamous cell carcinoma.
ConclusionMast cells may induce the tumor progression by providing a mitogenic stimulation or angiogenesis-the hallmark of the tumor growth and metastasis through the release of various mediators.
ON THE ISSUE OF THE ESSENCE OF LEASE RELATIONS AND THE RIGHT TO LEASE UNDER A VEHICLE LEASE AGREEMENT
Authors: Скворцова Татьяна Александровна , Кравец Ростислав Андреевич 
Published: June 2021

Статья посвящена рассмотрению сущности отношений по договору аренды транспортного средства. Охарактеризован договор аренды транспортного средства как разновидность аренды. Проанализирована правовая природа арендных отношений. Исследована сущность права аренды.
The article is devoted to the consideration of the essence of relations under the vehicle lease agreement. The vehicle lease agreement is characterized as a type of lease. The legal nature of lease relations is analyzed. The essence of the lease right is investigated.
LEGAL CAPACITY AND LEGAL CAPACITY OF A CITIZEN ENGAGED IN ENTREPRENEURIAL ACTIVITY
Authors: Скворцова Татьяна Александровна , Кнышова Виктория Владимировна 
Published: June 2021

В статье рассматриваются некоторые актуальные вопросы правоспособности и дееспособности граждан, осуществляющих предпринимательскую деятельность без образования юридического лица. Проанализированы различные виды правоспособности индивидуальных предпринимателей. Исследованы различные подходы ученых по проблематике определения объема дееспособности несовершеннолетних предпринимателей.
The article deals with some topical issues of legal capacity and legal capacity of citizens engaged in entrepreneurial activity without the formation of a legal entity. Various types of legal capacity of individual entrepreneurs are analyzed. Various approaches of scientists on the problem of determining the amount of legal capacity of underage entrepreneurs are investigated.
The preimaginal stages of Galerita ruficollis Dejean, 1825 and the position of the tribe Galeritini in the classification of ground beetles (Coleoptera, Carabidae)
Authors: Makarov Kirill V. , Matalin Andrey V. 
Published: June 2021

The complete development cycle of Galerita (Galerita) ruficollis Dejean, 1825 was studied for the first time. In laboratory, at a temperature of 22 °C and long-day conditions, the development from egg to adult lasted 58–60 days. The development of the third instar larva lasted particularly long (on average, 19 days), and the most intense increase in biomass (from 20 to 100 mg) was observed at that phase as well. The extended embryonic development (11–20 days) and the relatively short development time of the third instar larva were found to be characteristic ofG. ruficollis. The bifurcated protrusion of the anterior edge of the head was proven to represent an outgrowth of the frontal sclerite (frontale), but not of the nasale, as believed previously. The chaetotaxy ofGaleritalarvae is described in detail for the first time.Based on larval features, the monophyly of the Galeritini + Dryptini group is confirmed. Based on the morphology of the larvae and pupae, this group can be suggested as occupying a separate position within the Truncatipennia, possibly being related to the assemblage that includes Pterostichini, Harpalini, Licinini, Chlaenini, and Platynini. The monophyly of Zuphiitae (sensu Erwin and Sims 1984; Erwin 1985) and the Zuphiitae clade (sensu Ober and Maddison 2008) is confirmed.
Capter, quantifier, gouverner. L’assurance comportementale au service de la prévention ?
Authors: Jeanningros Hugo 
Published: June 2021

L’ère numérique et la multiplication des dispositifs de captation-traitement de l’information, parmi lesquels les objets connectés, offrent de nouvelles opportunités à une prévention plus centrée sur les individus. Parallèlement, le développement de l’économie comportementale fait apparaître de nouvelles modalités d’action sur les comportements de santé individuels. Peu investies par les pouvoirs publics, ces nouvelles techniques se diffusent parmi les assureurs privés, proposant des assurances personnalisées et comportementales, à rebours du statut de « payeur aveugle » que leur confère le système français de santé. À travers l’étude de la conception et de la mise en œuvre d’un programme de prévention santé personnalisé porté par une compagnie d’assurance privée française, nous éclairerons les modalités et enjeux de la rencontre entre assurance, prévention et économie comportementale.
Propuesta universitaria de educación en Colombia: “Profesional de la Vida Comunitaria y la Paz”.
Authors: Estrada-Montoya John Harold , Velosa-Amature Lyla Piedad , Junca-Rodríguez César Mauricio 
Published: June 2021

Introducción: La educación comunitaria tradicional ha desconocido a los sectores populares por considerarlos ignorantes y les responsabiliza y culpabiliza por su mala salud. Sus modos de organización social que les permiten resolver los problemas diarios con un saber y prácticas propias han sido poco exploradas. Objetivos: Proponer un proyecto educativo para la vida y la paz desde una praxis transformadora. Métodos: Investigación cualitativa crítico-hermenéutica, fundamentada en la Investigación Acción Participativa y la Educación Popular. Se sistematiza un proyecto de extensión solidaria anual realizado por casi 20 años por profesores y estudiantes de una Universidad colombiana con comunidades urbanas y rurales. Se realizaron 12 historias de vida y se acompañó a 25 estudiantes en sus trabajos de grado en temas relacionados con la propuesta. Resultados: Se presentan las reflexiones de las historias de vida y del acompañamiento de la Universidad a comunidades marginalizadas que cristalizan en el Programa del Profesional de la Vida Comunitaria y la Paz. Conclusiones: La salud pública debe acercarse a los sectores populares desde un horizonte de sentido político particular y reconocer el saber popular como una forma de construcción de mundo con la que es necesario ampliar su perspectiva de aproximación y de trabajo.