bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Alignment and Prosthesis Positioning Accuracy Between Robotics and Personalized 3D Preoperative Planning in Total Knee Arthroplasty
Authors: Lei Kai , Liu LiMing , Yang PengFei , Xiong Ran , Yang Liu , He Rui , Guo Lin 
Published: June 2021

Abstract
Purpose: Lower limb alignment is crucial in total knee arthroplasty (TKA). Previous studies have shown that robotics and personalized three-dimensional (3D) preoperative planning could improve postoperative alignment accuracy compared with conventional TKA, but comparison between the above two techniques has never been reported. The purpose of this study was to compare the alignment and prosthesis positioning accuracy between robotics and personalized 3D preoperative planning in TKA.Methods: A consecutive series of patients who received TKA in our Center from September 2020 to January 2021 were enrolled. After 1:2 matching, 52 and 104 patients were eventually included in robotics group and personalized 3D preoperative planning group, respectively. Multiple postoperative alignment variables, operation time, tourniquet time, length of hospital stay, hemoglobin (Hb) decrease at 1 and 3 days after operation were recorded and compared.Results: Compared with personalized 3D preoperative planning, robotics had significantly lower frontal tibial component (FTC) angle absolute deviation (P<0.001) and less FTC outliers (P<0.05). The postoperative hip-knee-ankle (HKA) angle and frontal femoral component (FFC) angle were different between two groups, while the absolute deviations were similar. Hb decreases of robotics were significantly lower than those of personalized 3D preoperative planning (P<0.001), while the operation time and tourniquet time were longer (P<0.001).Conclusion: Compared with personalized 3D preoperative planning, robotics has more accurate tibial component coronal alignment and less postoperative Hb decrease, while the operation time is significantly longer.Trial registration: The Chinese Clinical Trial Registry, ChiCTR2000036235. Registered 22 August 2020, http://www.chictr.org.cn/showproj.aspx?proj=59300
An Independent Prognostic Model Based on Ten Autophagy-Related Genes in Pancreatic Cancer
Authors: Tian Jiahui , wu yi , Zeng Xuan , Fang Xiaoxiao , Fu Chunyan 
Published: June 2021

Abstract
Purpose

Pancreatic cancer(PC) is a common cancer with high lethality and low survival rate. Autophagy is involved in the biological process of PC. Thus, we intended to explore the function of autophagy-related long noncoding RNA signature for survival assessment in PC.
Methods

Based on 10 autophagy-related lncRNAs, the prognostic model was attained through univariate and multivariate Cox regression analysis. Subsequently, the relationship network of 10 lncRNAs was crystallized in co-expression network and Sankey diagram. Survival analysis and ROC curve were used to evaluate the signature. GSEA was utilized to screen enriched gene sets.
Result

The OS has significant deference in low-risk group and high-risk group(P < 0.001). The ROC curve further proved the potential utility of the signature(AUC = 0.815). GSEA was significantly enriched in cancer-related gene sets.
Conclusion

The signature has potential to evaluate clinical prognosis in PC. The 10 autophagy-related lncRNAs may achieve great development for PC in target therapy field.
Clinical and Pathological Characteristics of 755 Patients with Skin Cancers in Hainan, China: A 12-Year Retrospective Study
Authors: Sun Lengbing , Lu Jiejie , Zhang Ming , Yang Xianxu , Wu Weiwei , Liu Qiao 
Published: June 2021

Abstract
Background: Skin cancers are the most frequent types of all malignant tumours with increasing incidence rates worldwide. Objectives: This study aimed to analyze the clinical–pathological characteristics of skin cancers in patients visited at the Department of Dermatology of the Fifth People's Hospital of Hainan Province from China during the last 12 years. Methods: The hospital database was searched for patients with skin cancers over a period of 12 years ( from January 1, 2009 to December 31, 2020) , and a retrospective review was conducted and a descriptive data analysis was undertaken on patients. Results: A total of 755 specimens of skin cancers were confirmed during this period, of which 696 (92.19%) were common skin cancers and of which 59(7.81%) were rare skin cancers. The incidence is on the rise year by year, with a marked decline in 2020. The common skin cancers were basal cell carcinoma (341, 48.99%), followed by squamous cell carcinoma (148 , 21.26%) and Bowen’s disease (109, 15.66%) . The range of age at the time of skin cancers was from 40 to 79 years (73.01% ). Males and females showed an almost similar incidence. The duration ranged from 7 days to 70 years, mainly occurred in 2 years( 53.30% ). The head, face and neck region were the most frequent location (452, 59.87% ), followed by extremity (107, 14.17% ) and trunk (87, 11.52% ). The accordance rates of clinical-pathological diagnosis in common skin cancers was about 43.14% , while that of rare skin cancers such as skin appendages was only 27.59% .Conclusions: Overall, head, face and neck region was the most common site for sun-related skin cancers in Hainan, China. BCC was the most common skin cancer followed by SCC and Bowen's disease. Moreover, skin cancers has a low coincidence rate of clinical-pathological diagnosis. Consequently, any suspicious lesion, for which the clinical diagnosis is uncertain, should be biopsied for histopathological examination to rule out malignancy.
Penicillinase Plasmid Australia type in Neisseria Gonorrhoeae Isolated in Poland
Authors: de Walthoffen Szymon Jerzy Walter 
Published: June 2021

Abstract
Purpose. Neisseria gonorrhoeae is an etiological agent of gonorrhea, which continues to be one of the most important public health problems. Currently, the most important problem in treatment is the mechanisms that determine resistance to drugs of the beta-lactam class, which are recommended for the treatment of gonorrhea. Chromosomal mutations are responsible for resistance to ceftriaxone and cefepime. The possibility of mutations in the gene encoding beta-lactamase (blaTEM) in the penicillinase plasmid may also turn out to be a serious threat. Methods. The occurrence of resistance encoded on penicillinase plasmid has been investigated. For this purpose, the susceptibility of bacteria was determined and the gene for resistance to beta-lactams as well as the plasmids themselves was typed. Results. Of the 333 strains tested, 21 (6.3%) had the beta-lactamase gene and produced penicillinase.The results allow to conclude that among the tested strains of N. gonorrhoeae occurred two of the beta-lactamase: TEM-1 and TEM-135. Most of the known penicillinase plasmid types of N. gonorrhoeae were demonstrated: Asian, African, Toronto/Rio plasmids and Australian variant.Conclusions.In the first three years, TEM-1 beta-lactamases dominated in N. gonorrhoeae, which were replaced by TEM-135 in the following years of the study. Not all molecular methods are capable of varying the types of penicillinase plasmids. A particularly noteworthy observation is the fact that the Australia-type of penicillinase plasmid (3270 bp) was identified for the first time in Europe, and the second time in the world.
Auditory-Cognitive Training For Adult Cochlear Implant Recipients: A Study Protocol for a Randomised Controlled Trial
Authors: Lawrence Blake J , Eikelboom Robert H , Jayakody Dona M.P. 
Published: June 2021

Abstract
Background: There is an urgent need to develop new therapies to improve cognitive function in adults following cochlear implant surgery. This study aims to determine if completing at-home computer-based brain training activities improve memory and thinking skills in adults following their first cochlear implant. Methods: This study will be conducted as a single-blind, head-to-head, randomised controlled trial (RCT). It will determine whether auditory training combined with adaptive computerised cognitive training will elicit greater improvement in cognition, sound and speech perception, mood, and quality of life outcomes in adult cochlear implant recipients, when compared to auditory training combined with non-adaptive (i.e., placebo) computerised cognitive training. Participants 18 years or older who meet the clinical criteria for a cochlear implant will be recruited into the study. Results: The results of this trial will clarify whether the auditory training combined with cognitive training will improve cognition, sound and speech perception, mood, and quality of life outcomes in adult cochlear implant recipients. Discussion: We anticipate that our findings will have implications for clinical practice in the treatment of adult cochlear implant recipients.Trial registration: ANZ clinical trial registration: ACTRN12619000609156
Significance of Preoperative Pancreatic MRI Findings in Predicting Factors for Postoperative Pancreatic Fistula after Distal Pancreatectomy for Pancreatic Cancer: A Retrospective Study
Authors: Fukada Masahiro , Murase Katsutoshi , Higashi Toshiya , Yokoi Ryoma , Tanaka Hideharu , Tanaka Yoshihiro , Okumura Naoki , Matsuhashi Nobuhisa , Takahashi Takao , Yoshida Kazuhiro 
Published: June 2021

Abstract
Background: Postoperative pancreatic fistula (POPF) is the most serious complication of distal pancreatectomy (DP). For patients with pancreatic cancer (PC), POPF can have a negative effect on both short- and long-term prognoses. This study aimed to identify clinical outcomes of POPF after DP for PC and predictive factors for POPF.Methods: This retrospective, single-institution study comprised 48 patients with PC who underwent open DP (excluding simultaneous resection of other organs and other pancreatic diseases) between January 2010 and December 2020 at the Gifu University Hospital. We statistically analyzed patient-, pancreas-, cancer-, and surgery-related factors for predicting outcomes and risk factors for POPF. Results: According to the International Study Group of Pancreatic Fistula (ISGPF) definition and grading, 11 (22.9%) of 48 patients had POPF grades B and C. Among 22 related factors, POPF was significantly associated with pancreatic width (p = 0.04) and the pancreas-to-muscle signal intensity ratio (SIR) on T1-weighted magnetic resonance imaging (MRI, p = 0.02) in univariate analysis. In multivariate analysis, both pancreatic width (≥23 mm, odds ratio [OR] 9.37; 95% confidence interval [CI] 1.22–202.40; p = 0.03) and SIR on T1-weighted MRI (≥1.37, OR 17.10; 95% CI 2.38–359.04; p = 0.003) were identified as independent predictive factors for POPF. Conclusion: Pancreatic width and pancreas-to-muscle SIR on T1-weighted MRI significantly correlated with POPF after DP for PC. These parameters may be potential imaging biomarkers for predicting POPF in pancreatic surgery.
Descending Thoracic Aorta–abdominal Aortic Bypass and Bilateral Renal Arterial Blood Circulation Reconstruction Are Effective in Atypical Coarctation of the Aorta With Heart Failure: a Case Report
Authors: Mikami Takuma , Kamada Takeshi , Yano Toshiyuki , Nakajima Tomohiro , Yasuda Naomi , Shibata Tsuyoshi , Nakanishi Keitaro , Harada Ryo , Naraoka Syuichi , Toda Kojiro , Nagano Nobutaka , Muranaka Atsuko , Kawaharada Nobuyoshi 
Published: June 2021

Abstract
Background: There are many reports on renal failure and heart failure due to coarctation of the aorta. However, there are no case reports in which revascularization dramatically improved left ventricular function in patients with progressive decline in left ventricular function. Herein, we present a rare case in which the left ventricular function dramatically improved after surgical treatment in a patient with progressive left ventricular dysfunction due to atypical coarctation of the aorta.Case presentation: A 58-year-old man underwent axilobifemoral bypass at another hospital for atypical coarctation of the aorta due to Takayasu’s arteritis. Approximately 10 years later, he was re-hospitalized for heart failure, and his left ventricular ejection fraction gradually decreased to 28%. Computed tomography showed severe calcification and stenosis at the same site from the peripheral thoracic descending aorta to the lower abdominal aorta up to the renal arteries, and aortography showed delayed bilateral renal artery blood flow. An increase in plasma renin activity was also observed. Despite the administration of multiple antihypertensive drugs, blood pressure control was insufficient. We decided to perform surgical treatment to improve progressive cardiac dysfunction due to increased afterload and activated plasma renin activity. Descending thoracic aorta–abdominal aorta bypass and revascularization of both renal arteries via a great saphenous vein grafts were performed. Postoperative blood pressure control improved, and the dose of antihypertensive drugs could be reduced. Plasma renin activity decreased, and transthoracic echocardiography performed 1.5 years later showed improvement in contractility with a left ventricular ejection fraction of 58%. Conclusion: In patients with atypical coarctation of the aorta and decreased bilateral renal blood flow, heart failure due to renal hypertension, and progressive decrease in left ventricular contractility, descending thoracic aorta–abdominal aortic bypass and bilateral renal artery recirculation can be extremely effective.
Multivariate Selection Index of Acerola Genotypes for Fresh Consumption Based on Fruit Physicochemical Attributes
Authors: Ferreira Maria A.R. , Vilvert João Claudio , Silva Bárbara O.S. , Ferreira Ianca Carneiro , Souza Flávio França , De Freitas Sergio Tonetto 
Published: June 2021

Abstract
Acerola (Malpighia emarginata DC.) is one of the most important fruit produced in the São Francisco Valley, a Semi-arid region in the Northeast of Brazil. This study aimed to evaluate the physicochemical quality of thirty-five acerola genotypes produced during two growing seasons in a Semi-arid region and to identify the best ones with potential for fresh consumption based on a multivariate selection index. Fruit of each genotype were harvested during two growing seasons at the maturity stage red-ripe, characterized by full red skin color. After harvest, the fruit were evaluated for diameter, mass, flesh firmness, soluble solids (SS), titratable acidity (TA), SS/TA ratio, ascorbic acid content and skin color. A multivariate selection index (SI) was applied for scoring and ranking the genotypes for fresh consumption based on red-ripe fruit physicochemical quality. According to the results, all physicochemical attributes had high variability among genotypes. The SI was a powerful tool for identifying genotypes with high potential for fresh consumption, since it allowed selecting genotypes with multiple desirable traits. In the first and second growing seasons, the SI identified the genotypes PROG 052 (SI = 76.1 and 78.9), BRS Rubra (SI = 74.1 and 99.5), Cabocla (SI = 72.3 and 70.7), Costa Rica (SI = 61.2 and 73.8) and PROG 069 (SI = 68.1 and 72.4) as the most promising ones for fresh consumption due to the presence of multiple desirable traits such as high diameter, mass, flesh firmness, SS, and SS/AT ratio, as well as lower acidity.
Unearthing The Alleviatory Mechanisms of Hydrogen Sulfide in Aluminum Toxicity in Rice
Authors: Zhu Chun Quan , Hu Wen Jun , Wei QianQian , Zhang Hui , Cao Xiao Chuang , Zhu Lian Feng , Kong Ya Li , Xiang Xing Jia , Liu Jia , Jin Qian Yu , Zhang Junhua 
Published: June 2021

Abstract
Hydrogen sulfide (H2S) improves aluminum (Al) resistance in rice; however, the underlying molecular mechanism remains unclear. In the present study, treatment with 30-μM Al significantly inhibited rice root growth and increased the total Al content and apoplastic and cytoplasm Al concentration in the rice roots. However, pretreatment with NaHS (H2S donor) reversed these negative effects. Transcriptomics and physiological experiments confirmed that H2S increased the ATP, sucrose, glutathione, and ascorbic acid contents, which was accompanied by decreased O2·- and H2O2 contents, to alleviate Al toxicity. H2S significantly inhibited ethylene emissions in the rice and then inhibited pectin synthesis and increased the pectin methylation degree to reduce cell wall Al deposition. The phytohormones indole-3-acetic and brassinolide were also involved in the alleviation of Al toxicity by H2S. In addition, other pathways of material and energy metabolism, secondary metabolism, cell wall components, signal transduction, and transcriptional and translational pathways in the rice roots were also regulated by H2S under Al toxicity conditions. These findings improve our understanding of how H2S affects rice responses to Al toxicity, which will facilitate further studies on crop safety.
Towards the Direct Detection of Viral Materials at the Surface of Protective Face Masks via Infrared Spectroscopy
Authors: Schorer Vanessa , Haas Julian , Stach Robert , Kokoric Vjekoslav , Groß Rüdiger , Münch Jan , Hummel Tim , Sobek Harald , Mennig Jan , Mizaikoff Boris 
Published: June 2021

Abstract
The ongoing COVID-19 pandemic represents a considerable risk for the general public and especially for health care workers. To avoid an overloading of the health care system and to control transmission chains, the development of rapid and cost-effective techniques allowing for the reliable diagnosis of individuals with acute respiratory infections are crucial. Uniquely, the present study focuses on a direct face mask sampling approach, as worn (i.e., used) disposable face masks contain exogenous environmental constituents, as well as endogenously exhaled breath aerosols. Optical techniques – and specifically infrared (IR) molecular spectroscopic techniques - are promising tools for direct virus detection at the surface of such masks. In the present study, a rapid and non-destructive approach for monitoring exposure scenarios via medical face masks using attenuated total reflection infrared spectroscopy is presented. Complementarily, IR external reflection spectroscopy was evaluated in comparison for rapid mask analysis. The utility of a face mask-based sampling approach was demonstrated by differentiating water, proteins, and virus-like particles sampled onto the mask. Data analysis using multivariate statistical algorithms enabled unambiguously classifying spectral signatures of individual components and biospecies. This approach readily extends towards the rapid detection of SARS-CoV-2 – as shown herein for the example of virus-like particles which are morphologically equivalent to authentic virus - without any additional sample preparation or elaborate testing equipment at laboratory facilities. Therefore, this strategy may be implemented as a routine large-scale monitoring routine, e.g., at health care institutions, nursing homes, etc. ensuring the health and safety of medical personnel.
Dental Health State Utility Values Associated with Compromised First Permanent Molar Teeth
Authors: Cant Aisling , Sanghvi Risha , Neves Aline de Almeida , Hosey Professor Marie Therese , Banerjee Professor Avijit , Warburton Fiona , Pennington Mark 
Published: June 2021

Abstract
Background The aim of this study was to generate utility data to support economic evaluation of interventions for compromised first permanent molars (cFPMs) and to assess the reliability of responses using alternative elicitation methods.MethodsFifty adult respondents attending a Paediatric Dentistry department with their child completed a questionnaire to elicit utility values for eight clinical treatment scenarios for a compromised first permanent molar tooth (cFPM). These scenarios included restorations, prosthetic replacements or presence of a gap (missing tooth). The question formats included a ranking, a visual analogue scale (VAS) and a time trade off (TTO) exercise.ResultsMean utility values for each health state were generated using the VAS and TTO data. A white filling generated the highest utility (0.786 [VAS], 0.763 [TTO]) and was ranked as the most favourable treatment option. An open gap generated the lowest utility (0.344 [VAS], 0.523 [TTO]). A closed gap (0.6392 [VAS]) was rated below various tooth restorations but above a traditional bridge (0.5944 [VAS]) or denture (0.4312 [VAS]), according to mean VAS scores. VAS responses showed better agreement (kappa=0.48) with the ranking exercise compared to TTO responses (kappa= -0.003).ConclusionsPlausible and broadly consistent values were generated with VAS and TTO, but TTO data seemed to be less reliable. These data allow comparison of treatment options involving extraction and gap closure or restoration of cFPMs using a single measure of patient preference.
The Protocol For The Prehabilitation For Thoracic Surgery Study: A Randomized Pragmatic Trial Comparing A Short Home-Based Multimodal Program To Aerobic Training In Patients Undergoing Video-Assisted Thoracoscopic Surgery Lobectomy
Authors: Liu Yuchao , Liu Zijia , Zhang Yuelun , Cui Yushang , Pei Lijian , Huang Yuguang 
Published: June 2021

Abstract
Background: Prehabilitation has been shown to have a positive effect on the postoperative recovery of functional capacity in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy. The optimal way to implement prehabilitation programs, such as the optimal forms of prehabilitation, duration, intensity, and methods to improve compliance, remained to be studied. This Prehabilitation for Thoracic Surgery Study will compare the effectiveness of multimodal and aerobic training-only programs in patients undergoing thoracoscopic lobectomy.Methods: This randomized pragmatic trial will be conducted in Peking Union Medical College Hospital (PUMCH) and include 100 patients who are eligible to undergo VATS lobectomy. Patients will be randomized to a multimodal or aerobic training group. Prehabilitation training guidance will be provided by a multidisciplinary care team. The patients in the multimodal group will perform aerobic exercises, resistance exercises, breathing exercises, psychological improvement strategies, and nutritional supplementation. Meanwhile, the patients in the aerobic group will conduct only aerobic exercises. The interventions will be home-based and supervised by medical providers. The patients will be followed up until 30 days after surgery to investigate whether the multimodal prehabilitation program differs from the aerobic training program in terms of the magnitude of improvement in functional capability pre- to postoperatively. The primary outcome will be the perioperative 6-minute walk distance (6MWD). The secondary outcomes will include the postoperative pulmonary functional recovery status, health-related quality of life score, incidence of postoperative complications, and clinical outcomes.Discussion: Prehabilitation remains a relatively new approach that is not widely performed by thoracic surgery patients. The existing studies mainly focus on unimodal interventions. While multimodal prehabilitation strategies have been shown to be preferable to unimodal strategies in a few studies, the evidence remains scarce for thoracic surgery patients. The results of this study will contribute to the understanding of methods for thoracoscopic lobectomy patients.Trial registration: ClinicalTrials.gov, NCT04049942, registered on August 8, 2019, https://clinicaltrials.gov/ct2/show/NCT04049942