bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved Urine DNA Methylation Panel for Early Bladder Cancer Detection
Authors: Fang Qixun , Zhang Xu , Nie Qing , Hu Jianqiang , Zhou Shujun , Wang Chaojun 
Published: July 2021

Abstract
PurposeBladder cancer is one of the most common malignancies but the corresponding diagnostic methods are either invasive or limited in specificity and/or sensitivity. Detecting DNA methylation using urine sample has been reported as a potential method for bladder cancer detection. This study aimed to develop a bladder cancer detecting panel by improving published panels and validated the panel performance with clinical samples. Materials and MethodsRelated researches were reviewed and the biomarkers of most potential were selected into a new panel. A total of 92 samples were included in this study, 45 of which had their methylation status measured by RRBS and others measured by qMSP. RRBS data was used to compare performance of the new panel and the panels it derided from while qMSP data was used to validate panel performance in occasions of clinical use. To further investigate panel detection limit and result reproducibility, synthesized samples were repeatedly measured in different time and concentration. ResultsThree biomarkers (PCDH17, POU4F2 and PENK) were selected to construct a new panel P3. P3 panel achieved an accuracy of 0.836 and an AUC of 0.964 with RRBS while the accuracy and AUC with qMSP were 0.915 and 0.948, showing more balanced specificity and sensitivity and higher accuracy compared to individual marker. Detection limit study showed high sensitivity in plasmid sample and the results can be reproduced with acceptable deviations. ConclusionOverall, the P3 panel achieved relatively high sensitivity and accuracy in bladder cancer detection.
A New Integrative Model For The Co-Occurrence of Non-Suicidal Self-Injury Behaviours and Eating Disorder Symptoms
Authors: Krug Isabel , Arroyo Mercedes Delgado , Giles Sarah , Dang An Binh , Kiropoulos Litza , De Paoli Tara , Buck Kim , Treasure Janet , Fuller-Tyszkiewicz Matthew 
Published: July 2021

Abstract
Objective: The high co-occurrence of non-suicidal self-injury (NSSI) behaviours and eating disorder (ED) symptoms suggests these conditions share common aetiological processes. We assessed whether insecure attachment and maladaptive schemas were related to NSSI and ED symptoms through affect dysregulation, impulsivity, self-esteem, and body dissatisfaction. Method:123 ED patients and 531 individuals from the community completed an online survey, which included measures assessing the variables of interest. Results: The model was a good fit for the ED group, however only a revised model reached an acceptable fit for the community sample. In the community group, impulsivity was a shared predictor for NSSI and bulimic symptoms, whereas affect dysregulation was a unique predictor for NSSI in both the ED and community groups. No other variables were shared by NSSI and ED symptoms in the two groups. Both attachment and maladaptive schemas were implicated in the pathways leading to ED and NSSI symptoms in the clinical ED and the community sample. The variance explained for NSSI and drive for thinness were highest for the clinical ED sample (29% and 57% respectively). Conclusion: Common factors may underlie NSSI and ED symptoms, however, these factors may become more specific and less prevalent as a function of disorder severity.
The Effect of Educational Intervention on Promotion of Preventive Behavior of Knee Osteoarthritis in Women Over 40 Based on the Theory of Planned Behavior in Sample of Iranian Women
Authors: Jeihooni Ali Khani , Fereidouni Zhila , Bahmandoost Mina , Harsini Pooyan Afzali 
Published: July 2021

Abstract
Objectives. The purpose of this study was designed and conducted so that the educational intervention based on the theory of planned behavior be performed in order to promote preventive behaviors of knee osteoarthritis in women over 40 living in, Fars, I.R.IranMethods. This research is a quasi-experimental study. The subjects of the study were 100 women over the age of 40 who were under the coverage of Health Centers. The data collection tool was a questionnaire TPB. The educational intervention program consisted of 8 training sessions on the adoption of preventive behaviors from knee osteoarthritis based on the theory of planned behavior (TPB). Results. There was a significant difference between the experimental and control groups in terms of the scores for attitude, subjective norms, perceived control behavior, intention and behavior before and after the intervention. However, three months after the intervention, there was a significant increase in each of the constructs in the experimental, but there was no such a significant difference in the control group.Conclusion. With regard to the findings of this study, performing educational intervention based on theories and changing behavior modes particularly the TPB aiming at reducing knee osteoarthritis can lead to its morbidity reduction.
Salvage Treatment of Acute Respiratory Failure after Transcomposite Myocutaneous Flaps Transplantation for Chronic Empyema Combined with Chest wall sinus: A Case Report
Authors: Wang Lei , He Zhongliang 
Published: July 2021

Abstract
BackgroundChronic empyema with chest wall sinus is a complex and refractory disease caused by multiple factors.It may be combined with bronchopleural fistula, residual bone and other necrotic tissue,causing local infection difficult to control, and the disease is a vicious circle.Case presentationThis paper reports a 62-year-old male patient who underwent right pneumonectomy for squamous cell carcinoma of the lung 11 years ago and began to develop empyema with purulent sinus in the anterior chest wall 3 years ago. Therefore, he was admitted to our medical center for further treatment. Chest computed tomography (CT) showed the right pleural effusion with the chest wall rupture sinus. According to his clinical symptoms and imaging examination, he was diagnosed as chronic empyema with chest wall sinus.Due to the large empyema cavity,the patient should be treated with free vastus lateralis musculocutaneous flap combined with pedicled pectoralis major muscle flap transplantation.After the operation, acute respiratory failure occurred due to left lung aspiration pneumonia.ConclusionsAfter a series of treatment measures such as tracheal intubation, tracheotomy, anti-infection, maintenance of circulatory stability, and rehabilitation training, he was finally rescued and cured.Follow-up after discharge showed that the tissue flap survived and empyema was eliminated.
WITHDRAWN: Diagnostic Performance of Immediate Angiography Derived Quantitative Flow Ratio In Patients After Second Generation Drug Eluting Stent And Bioresorable Scaffold Implantation
Authors: Li Zhengwei , Zhan Jiachen , Han Jia , Fu Guosheng , Jin Chongying 
Published: July 2021

Abstract
Quantitative flow ratio (QFR) is a novel angiography derived fractional flow reserve (FFR). However, its diagnostic performance has only be validated in native coronary lesion but not yet in vessels after stent implantation. This study aims to evaluate the diagnostic performance of QFR in coronary vessels immediately after everolimus eluting stent (EES) and bioresorbable scaffold (BRS) implantation. This is a retrospective, two centers, validation cohort study. 73 stable angina patients who received at least one native vessel EES/BRS implantation with immediate FFR assessment were screened. Cases with aorta-ostial stenoses, bridge vessel at the distal of targated vessel, acute coronary syndrome, previous coronary artery bypass grafting, age < 18 years, lack of ≥ 2 final angiographic projections were excluded. Contrast QFR assessment was performed blinded to FFR assessment. A good correlation (r = 0.680, p < 0.001) was found between QFR and FFR. In the EES implantation cohort, a good correlation (r = 0.769, p < 0.001) was found between QFR and FFR, while moderate correlation (r = 0.446, p = 0.038) was found in the BRS cohort. The area under the ROC curve for detecting FFR ≤ 0.86 was 0.883 for the total subjects. QFR assessment after immediate EES/BRS implantation is feasible, and remains good correlation and agreement with FFR. QFR might be a promising tool for guiding stent implantation optimizing to improve clinical outcomes.
Potential Metal Chelating Ability of Mycosporine-Like Amino Acids: A Computational Research
Authors: Varnali Tereza , Bozoflu Mert , Şengönül Hüseyin , Kurt Seher İ. 
Published: July 2021

Abstract
Mycosporine-like amino acids (MAAs) are low molecular-weight (<400 Da) water soluble secondary metabolites that are attributed many functions such as antioxidants, compatible solutes, nitrogen reservoirs and especially, photostable UV-protectants. Recently, they are attracting attention due to their biotechnological and industrial potential for anti-aging and wound healing properties as well. In this study, we explored the metal chelating capacity of selected MAAs ( 4-deoxygadusol, mycosporine-glycine, mycosporine-taurine, palythine, poryphyra-334, shinorine, mycosporine-2-glycine and euhalothece-362) making use of dft calculations. We report model structures of ferrous and ferric ion-MAA complexes and their binding affinities in relation to their structural differences and multiple sites available for chelation on the MAAs. We also investigated calcium ion complexes for mycosporine-glycine, shinorine, porphyra-334 and mycosporine-2-glycine. Our findings support previous suggestions made to explain some experimental results obtained in earlier studies on MAAs. Lastly, we briefly mention the findings in the context of early life and hence relevance to astrobiology.
Mental Health Classification and Quality of Life of Empty-nest Elderly in China: A Latent Profile Analysis
Authors: Su Hong , Zhou Yuqiu , Cai Yunjiang , Wang Yun 
Published: July 2021

Abstract
Background：Latent profile analysis was used to identify the profiles of empty-nest elderly’s mental health. Associations of the profiles with quality of life were then examined. Methods: Three hundred and fifty empty-nest elderly adults in China were investigated with Elderly Mental Health Questionnaire and the Chinese version of the SF-36. Latent profile analysis was used to analyze the data. Results: A three-profile mental health model provided the best fit to the data. The resulting profiles were low mental health, moderate mental health, and high mental health. There were significant differences in quality of life among different profiles of mental health.Conclusion: The results provide a new and expanded view of empty nesters’ mental health, which may be used to improve empty-nest elderly’s quality of life.
The Impact of An Innovative Summer Camp for Community Older Adults
Authors: Yeh Mei-Hua , Huang Cheng-Hsien , Lin Yu-Chih , Huang Tung-Jung , Chen Mei-Yen 
Published: July 2021

Abstract
Background

Healthy aging with dignity and aging in place are important concepts for most Taiwanese individuals, which can hopefully affect health policies. However, many elders have been encouraged to stay at home during the COVID-19 pandemic since January 2020. Consequently, most elders limited their social participation in a previous regular activity in the community center, which undermined the strategies for healthy aging. Few studies have explored how to promote or maintain holistic health and physical fitness for community elders during the COVID-19 worldwide. Therefore, this study aimed to establish and evaluate the impact of an innovative summer camp program for older adults in the rural community.
Methods

A quasi-experimental pre-post-test design was used. The innovative summer camp (ISC) was based on a standardized protocol of modified Baduanjin exercise combined with three recreation breathing games. Participants were recruited from three community centers around the western coastal Yunlin County between June and August 2020. ISC program was designed and demonstrated by the research team and conducted by each community care worker for 90 minutes per day, five days per week, for 12 weeks. The paired t-test was used to measure the physical biomarkers, pulmonary lung function, and health-related fitness changes.
Results

Sixty-eight participants completed this study. The findings indicated that the ISC program significantly improved elderly individuals’ physiological biomarkers and health-related fitness, including reduced body weight, waistline, systolic blood pressure, and increased forced vital capacity, biceps arm flexion, sit and stand from a chair, step with a knee up in situ, and stand on one foot with eyes open. Besides wearing a facemask during the activity, almost all participants reported that they felt happy, satisfied and hoped that this program can be continued in their community center.
Conclusion

This pilot study supported the finding that a three-month ISC program can improve physical biomarkers and health-related fitness. The results strongly suggested that community care workers can employ the proposed ISC program as routine activity for community elders.
Robust Metabolic Transcriptional Components in 34,494 Patient-Derived Samples and Cell Lines
Authors: Leeuwenburgh Vincent Christiaan , Urzúa-Traslaviña Carlos G. , Bhattacharya Arkajyoti , Walvoort Marthe T.C. , Jalving Mathilde , de Jong Steven , Fehrmann Rudolf S.N. 
Published: July 2021

Abstract
Background: Patient-derived bulk expression profiles of cancers can provide insight into transcriptional changes that underlie reprogrammed metabolism in cancer. These profiles represent the average expression pattern of all heterogeneous tumor and non-tumor cells present in biopsies of tumor lesions. Hence, subtle transcriptional footprints of metabolic processes can be concealed by other biological processes and experimental artifacts. However, consensus Independent Component Analyses (c-ICA) can capture statistically independent transcriptional footprints, of both subtle and more pronounced metabolic processes. Methods: We performed c-ICA with 34,494 bulk expression profiles of patient-derived tumor biopsies, non-cancer tissues, and cell lines. Gene set enrichment analysis with 608 gene sets that describe metabolic processes was performed to identify transcriptional components enriched for metabolic processes (mTCs). The activity of these mTCs were determined in all samples to create a metabolic transcriptional landscape. Results: A set of 555 mTCs were identified of which many were robust across different datasets, platforms, and patient-derived tissues and cell lines. We demonstrate how the metabolic transcriptional landscape defined by the activity of these mTCs in samples can be used to explore associations between the metabolic transcriptome and drug sensitivities, patient outcomes, and the composition of the immune tumor microenvironment. Conclusions: To facilitate the use of our transcriptional metabolic landscape, we have provided access to all data via a web portal ( www.themetaboliclandscapeofcancer.com ). We believe this resource will contribute to the formulation of new hypotheses on how to metabolically engage the tumor or its (immune) microenvironment.
Naringenin Regulates FKBP4/NR3C1/TMEM173 Signaling Pathway in Autophagy and Proliferation of Breast Cancer and Tumor-Infiltrating Dendritic Cell Maturation
Authors: Xiong Hanchu , Chen Zihan , Lin Baihua , Chen Cong , Li Zhaoqing , Jia Yongshi , Wang Linbo , Zhou Jichun 
Published: July 2021

Abstract
Background

TMEM173 is a pattern recognition receptor detecting cytoplasmic nucleic acids and transmits cGAS related signals that activate host innate immune responses. It has also been found to be involved in tumor immunity and tumorigenesis.
Methods

Bc-GenExMiner, PROMO and STRING database were used for analyzing clinical features and interplays of FKBP4, TMEM173 and NR3C1. Transient transfection, western blotting, quantitative real-time PCR, luciferase reporter assay, immunofluorescence and nuclear and cytoplasmic fractionation were used for regulation of FKBP4, TMEM173 and NR3C1. Both knockdown and overexpression of FKBP4, TMEM173 and NR3C1 were used to analyze effects on autophagy and proliferation of breast cancer (BC) cells. Flow cytometry analysis, cytokine analysis and exosome isolation and identification were utilized to test tumor-infiltrating dendritic cell (TIDC) maturation.
Results

In this study, we firstly identified that FKBP4/NR3C1 axis was a novel negative regulator of TMEM173 in BC cells. The effect of FKBP4 appeared to be at the transcriptional level of TMEM173 since it could suppress the promoter activity of TMEM173, thereby affecting TMEM173 at mRNA and protein levels. Bioinformatics and in vitro experiments further demonstrated that FKBP4 regulated TMEM173 via regulating nuclear translocation of NR3C1. We then reported that naringenin, a flavonoid, could enhance autophagy and suppress proliferation of BC cells through the induction of TMEM173 in vitro and in vivo. Naringenin was also found to promote TIDC maturation through FKBP4/NR3C1/TMEM173 axis of both BC cells exosome and DC itself.
Conclusion

We demonstrated that naringenin could induce cell proliferation inhibition and cytoprotective autophagy of BC cells and enhance TIDC maturation, at least in part, though regulation of FKBP4/NR3C1/TMEM173 signaling pathway. Identification of FKBP4/NR3C1 axis as a novel TMEM173 regulator would provide insights for novel anti-tumor strategy against BC among tumor microenvironment.
Predicting Indian Ocean Cyclone Parameters Using an Artificial Intelligence Technique
Authors: Chand C. Purna , Ali M.M. , Himasri B. , Bourassa Mark A , Zheng Yangxing 
Published: July 2021

Abstract
Precise prediction of a cyclone track with wind speed, pressure, landfall point and the time of crossing the land are very essential for the disaster management and mitigation including the evacuation processes. In this paper, we use an artificial neural network (ANN) approach to estimate the cyclone parameters. For this purpose, these parameters are obtained from the International Best Track Archive for Climate Stewardship (IBTrACS), National Oceanic and Atmospheric Administration (NOAA). Since ANN benefits from a large number of data points, each cyclone is divided into different segments. We use the past information to predict the cyclone geophysical parameters. The predicted values are compared with the observations.
Diverse Community Leaders’ Perspectives About Quality Primary Healthcare and Healthcare Measurement: Qualitative Community-based Participatory Research
Authors: Culhane-Pera Kathleen , Pergament Shannon L , Kasouaher Maiyia Y , Pattock Andrew M , Dhore Naima , Kaigama Cindy N , Alison Marcela , Scandrett Michael , Thao Mai See , Satin David J 
Published: July 2021

Abstract
BackgroundHealthcare quality measurements in the United States illustrate disparities by racial/ethnic group, socio-economic class, and geographic location. Redressing healthcare inequities, including measurement of and reimbursement for healthcare quality, requires partnering with communities historically excluded from decision-making. Quality healthcare is measured according to insurers, professional organizations and government agencies, with little input from diverse communities. This community-based participatory research study aimed to amplify the voices of community leaders from seven diverse urban communities in Minneapolis-Saint Paul Minnesota, view quality healthcare and financial reimbursement based on quality metric scores.MethodsA Community Engagement Team consisting of one community member from each of seven urban communities —Black/African American, Lesbian-Gay-Bisexual-Transgender-Queer-Two Spirit, Hmong, Latino/a/x, Native American, Somali, and White—and two community-based researchers conducted listening sessions with 20 community leaders about quality primary healthcare. Transcripts were inductively analyzed and major themes were identified.ResultsListening sessions produced three major themes, with recommended actions for primary care clinics. #1: Quality Clinics Utilize Structures and Processes that Support Healthcare Equity #2: Quality Clinics Offer Effective Relationships, Education, and Health Promotion#3: Funding Based on Current Quality Measures Perpetuates Health InequitiesConclusionCommunity leaders identified ideal characteristics of quality primary healthcare, most of which are not currently measured. They expressed concern that linking clinic payment with quality metrics without considering social and structural determinants of health perpetuates social injustice in healthcare.
Duodenal Gastrointestinal Stromal Tumour Imitating as Pancreatic Head Tumour: A Typical Case of Whodunit
Authors: Varshney Vaibhav Kumar , Nayar Raghav , Khera Sudeep , Yadav Taruna , Varshney Bharti , Bhargava Narendra 
Published: July 2021

Abstract
Duodenal gastrointestinal stromal tumours (D-GISTs) are rare disease. It may arise commonly from second or third part of the duodenum and can be erroneously diagnosed as a pancreatic head tumour due to proximity and morphology on imaging studies. We present a case of a sixty-year-old woman who presented with abdominal pain and was diagnosed as a case of pancreatic neuroendocrine tumour on radiologic imaging and granulomatous lesion on aspiration cytology. On laparotomy, a ~5x3 cm mass was noted in the pancreatic head and pancreatoduodenectomy was performed. Histopathology reported an exophytic GIST arising from the second part of the duodenum.Hence, D-GIST can invade into the pancreas and mimic pancreatic head tumour; therefore, these tumours should be kept in the differential diagnosis of an atypical pancreatic head mass.