bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Inferior Vena Cava Filter Retrieval in Patients on Chronic Anticoagulation Therapy
Authors: Fletcher Savannah , Plotnik Adam , Srinivasa Ravi N. , Chick Jeffrey Forris Beecham , Moriarty John M. 
Published: January 2021

AbstractPurpose of reviewDescribe the role of inferior vena cava filter (IVCF) retrieval in patients on chronic anticoagulation given the overlap of these treatment options in the management of patients with venous thromboembolic disease.Recent findingsDespite the increase in IVCF retrievals since the Food and Drug Administration safety communications in 2010 and 2014, retrieval rates remain low. Previous studies have shown that longer filter dwell times are associated with greater risk for filter complications and more difficulty with filter retrievals. Recent findings suggest that complications are more frequent in the first 30 days after placement.SummaryThe decision to retrieve an optional IVCF is individualized and requires diligent follow-up with consistent re-evaluation of the need for the indwelling IVCF, particularly in those on long-term anticoagulation therapy.
Acid Suppressant Therapy: a Step Forward with Potassium-Competitive Acid Blockers
Authors: Scarpignato Carmelo , Hunt Richard H. 
Published: January 2021

AbstractPurpose of the reviewThe introduction of H2-receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) into clinical practice has been a real breakthrough in the treatment of acid-related diseases. PPIs are now the standard of care for the treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD),Helicobacter pyloriinfection, NSAID-associated gastroduodenal lesions, and upper gastrointestinal bleeding (UGIB). However, despite their effectiveness, PPIs display some intrinsic limitations, which underlie the unmet clinical needs that have been identified over the past decades.Recent findingsTo address these needs, new long-acting compounds (such as tenatoprazole and AGN 201904-Z) and new PPI formulations, including instant release omeprazole (IR-omeprazole) and dexlansoprazole modified release (MR), have been developed. However, a major advance has been the development of the potassium-competitive acid blockers (P-CABs), which block the K+,H+-ATPase potassium channel, are food independent, are reversible, have a rapid onset of action, and maintain a prolonged and consistent elevation of intragastric pH. Vonoprazan and tegoprazan are the two marketed P-CABs while two other compounds (namely fexuprazan and X842) are under active development. Available for almost 6 years now, a considerable experience has been accumulated with vonoprazan, the efficacy and safety of which are detailed in this paper, together with the preliminary results of the other members of this new pharmacologic class.SummaryBased on the available evidence, erosive reflux disease,H. pyloriinfection, and secondary prevention of NSAID gastropathy can be considered established indications for vonoprazan and are being explored for tegoprazan and fexuprazan. In the treatment of severe (LA C & D) reflux esophagitis andH. pylorieradication, vonoprazan proved to be superior to PPIs. Other uses of P-CABs are being evaluated, but clinical data are not yet sufficient to allow a definitive answer on its efficacy and possible superiority over the current standard of care (i.e., PPIs). The most notable indication of upper GI (non-variceal) bleeding, where vonoprazan would prove superior to PPIs, has not yet been explored. The safety of P-CABs in the short-term overlaps that of PPIs, but data from long-term treatment are needed.
Single Scans of Ti-6Al-4V by Directed Energy Deposition: A Cost and Time Effective Methodology to Assess the Proper Process Window
Authors: Carrozza Alessandro , Mazzucato Federico , Aversa Alberta , Lombardi Mariangela , Bondioli Federica , Biamino Sara , Valente Anna , Fino Paolo 
Published: January 2021

AbstractDirected energy deposition is an additive manufacturing technology which usually relies on prototype machines or hybrid systems, assembled with parts from different producers. Because of this lack of standardization, the optimization of the process parameters is often a mandatory step in order to develop an efficient building process. Although, this preliminary phase is usually expensive both in terms of time and cost. The single scan approach allows to drastically reduce deposition time and material usage, as in fact only a stripe per parameters combination is deposited. These specimens can then be investigated, for example in terms of geometrical features (e.g. growth, width) and microstructure to assess the most suitable process window. In this work, Ti-6Al-4V single scans, produced by means of directed energy deposition, corresponding to a total of 50 different parameters combinations, were analyzed, focusing on several geometrical features and relative parameters correlations. Moreover, considering the susceptibility of the material to oxygen pick-up, the necessity of an additional shielding gas system was also evaluated, by comparing the specimens obtained with and without using a supplementary argon flow. A process window, which varies according to the user needs, was found together with a relationship between microstructure and process parameters, in both shielding scenarios.Graphic Abstract
Large scale land investments and food security in agropastoral areas of Ethiopia
Authors: Bekele Adugna Eneyew , Dries Liesbeth , Heijman Wim , Drabik Dusan 
Published: January 2021

AbstractIn Ethiopia, large scale land investments have been expanding into pastoral regions. However, little is known about the consequences of these investments on the food security of the pastoral community. Using Living Standard Measurement Survey data of the World Bank, we find that, on average, about 32% of the respondents from the (agro-)pastoral regions are food insecure. After controlling for confounders, proximity to large scale land investments is associated with additional food intake of up to 745 kcal per day per adult compared to the households located farther away from a large scale land investment. Proximity to large scale land investment has no significant effect on the coping strategies based food security. For households located in proximity to a large scale land investment, food intake significantly increases with access to roads and markets. Proximity to a large scale land investment has a positive effect on household food consumption not necessarily because of direct benefits from large scale land investments, but due to land and soil quality near the large scale land investments.
Intranasal drug delivery: opportunities and toxicologic challenges during drug development
Authors: Keller Lea-Adriana , Merkel Olivia , Popp Andreas 
Published: January 2021

Abstract
Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has increased. This review article summarises information on intranasal administration for local and systemic delivery, as well as for CNS indications. Nasal delivery offers many advantages over standard systemic delivery systems, such as its non-invasive character, a fast onset of action and in many cases reduced side effects due to a more targeted delivery. There are still formulation limitations and toxicological aspects to be optimised. Intranasal drug delivery in the field of drug development is an interesting delivery route for the treatment of neurological disorders. Systemic approaches often fail to efficiently supply the CNS with drugs. This review paper describes the anatomical, histological and physiological basis and summarises currently approved drugs for administration via intranasal delivery. Further, the review focuses on toxicological considerations of intranasally applied compounds and discusses formulation aspects that need to be considered for drug development.

Graphical abstract
Organoid technology for personalized pancreatic cancer therapy
Authors: Bengtsson Axel , Andersson Roland , Rahm Jonas , Ganganna Karthik , Andersson Bodil , Ansari Daniel 
Published: January 2021

Abstract
Background
Pancreatic ductal adenocarcinoma has the lowest survival rate among all major cancers and is the third leading cause of cancer-related mortality. The stagnant survival statistics and dismal response rates to current therapeutics highlight the need for more efficient preclinical models. Patient-derived organoids (PDOs) offer new possibilities as powerful preclinical models able to account for interpatient variability. Organoid development can be divided into four different key phases: establishment, propagation, drug screening and response prediction. Establishment entails tailored tissue extraction and growth protocols, propagation requires consistent multiplication and passaging, while drug screening and response prediction will benefit from shorter and more precise assays, and clear decision-making tools.

Conclusions
This review attempts to outline the most important challenges that remain in exploiting organoid platforms for drug discovery and clinical applications. Some of these challenges may be overcome by novel methods that are under investigation, such as 3D bioprinting systems, microfluidic systems, optical metabolic imaging and liquid handling robotics. We also propose an optimized organoid workflow inspired by all technical solutions we have presented.
A&nbsp;collective case study of supervision and competence judgments on the inpatient internal medicine ward
Authors: Gilchrist Tristen , Hatala Rose , Gingerich Andrea 
Published: January 2021

Introduction Workplace-based assessment in competency-based medical education employs entrustment-supervision scales to suggest trainee competence. However, clinical supervision involves many factors and entrustment decision-making likely reflects more than trainee competence. We do not fully understand how a supervisor’s impression of trainee competence is reflected in their provision of clinical support. We must better understand this relationship to know whether documenting level of supervision truly reflects trainee competence.
Methods We undertook a collective case study of supervisor-trainee dyads consisting of attending internal medicine physicians and senior residents working on clinical teaching unit inpatient wards. We conducted field observations of typical daily activities and semi-structured interviews. Data was analysed within each dyad and compared across dyads to identify supervisory behaviours, what triggered the behaviours, and how they related to judgments of trainee competence.
Results Ten attending physician-senior resident dyads participated in the study. We identified eight distinct supervisory behaviours. The behaviours were enacted in response to trainee and non-trainee factors. Supervisory behaviours corresponded with varying assessments of trainee competence, even within a dyad. A change in the attending’s judgment of the resident’s competence did not always correspond with a change in subsequent observable supervisory behaviours.
Discussion There was no consistent relationship between a trigger for supervision, the judgment of trainee competence, and subsequent supervisory behaviour. This has direct implications for entrustment assessments tying competence to supervisory behaviours, because supervision is complex. Workplace-based assessments that capture narrative data including the rationale for supervisory behaviours may lead to deeper insights than numeric entrustment ratings.
Contribution of root respiration to total soil respiration during non-growing season in mine reclaimed soil with different covering-soil thicknesses
Authors: Chen Min , Chen Xiaoyang , Hu Zhiyong , Fan Tingyu , Zhang Shiwen , Liu Ying 
Published: January 2021

AbstractAn accurate assessment of root respiration in mine reclaimed soil is important for effectively evaluating mining area ecosystems. This study investigated dynamic changes in root respiration and the contribution of root respiration to total soil respiration (Rr/Rt ratio) during the non-growing season in mine reclaimed soil, with different covering-soil thicknesses. According to the covering-soil thicknesses, the study area was divided into four sites: 10–25 cm (site A), 25–45 cm (site B), 45–55 cm (site C), and 55–65 cm (site D). From November 2017 to April 2018 (except February in 2018), the soil respiration, root respiration, temperature at 5 cm, water content, and root biomass were measured. The results show that soil temperature and root respiration exhibited similar diurnal and monthly variations. The root respiration is strongly influenced by soil temperature during the non-growing season, with an exponential and positive relationship (P < 0.001). Root respiration varies with the covering-soil thickness and is greatest with a covering-soil thickness of 25–45 cm. The Rr/Rt ratio also exhibits monthly variations. During the non-growing season, the mean value of the Rr/Rt ratio is 51.15% in mine reclaimed soil. The study indicates that root respiration is the primary source of soil respiration and is an important factor for estimating the potential emission of soil CO2 from mine reclaimed soil at the regional scale.
Lead-Free Perovskite Materials for Solar Cells
Authors: Wang Minghao , Wang Wei , Ma Ben , Shen Wei , Liu Lihui , Cao Kun , Chen Shufen , Huang Wei 
Published: January 2021

AbstractThe toxicity issue of lead hinders large-scale commercial production and photovoltaic field application of lead halide perovskites. Some novel non- or low-toxic perovskite materials have been explored for development of environmentally friendly lead-free perovskite solar cells (PSCs). This review studies the substitution of equivalent/heterovalent metals for Pb based on first-principles calculation, summarizes the theoretical basis of lead-free perovskites, and screens out some promising lead-free candidates with suitable bandgap, optical, and electrical properties. Then, it reports notable achievements for the experimental studies of lead-free perovskites to date, including the crystal structure and material bandgap for all of lead-free materials and photovoltaic performance and stability for corresponding devices. The review finally discusses challenges facing the successful development and commercialization of lead-free PSCs and predicts the prospect of lead-free PSCs in the future.
Inhibition of the filamentation of Candida albicans by Borojoa patinoi silver nanoparticles
Authors: Gómez-Garzón Marcela , Gutiérrez-Castañeda Luz D. , Gil Camilo , Escobar Carlos H. , Rozo Ana P. , González María E. , Sierra Edgar V. 
Published: January 2021

AbstractCandida albicansis fungus capable of changing from yeast to filamentous form when it’s transformed from a normal commensal to an opportunistic pathogen. The development of alternatives that interfere with this transition could be an effective way to reduce candidiasis. In this regard, evaluate the inhibitory effect of twoBorojoa patinoisilver nanoparticles (AgNPs) produced by green synthesis at 5 °C and 25 °C on the process of filamentation ofCandida albicans. The percentage of inhibition of filamentous forms ofC. albicansATCC10231 andC. albicansSC5314 with AgNPs was determined. Results showed that temperature of synthesis affected both the shape and size of silver nanoparticles synthesized usingBorojoa patinoiextracts. The inhibition percentage of filamentous forms ofCandida albicansATCC10231 when treated with silver nanoparticles synthesized at 5 °C was 85.9% and at 25 °C it was 40%.C. albicansSC5314 when treated with AgNP synthesized at 5 °C was 97.2% and at 25 °C it was 64%. Cell toxicity assay showed that at 100ng/ml, AgNPs synthesized at 25 °C were safe in MES-OV CRL-3272 cell line. Our results showed that the silver nanoparticles obtained fromBorojoa patinoiare inhibitors of the filamentous process ofC. albicans.
DGS based monopole circular-shaped patch antenna for UWB applications
Authors: Gopi Dattatreya , Vadaboyina Appala Raju , Dabbakuti J. R. K. Kumar 
Published: January 2021

AbstractA simple low profile defected ground structure based monopole circular-shaped patch antenna is proposing for ultrawide-band applications. The design allows for a simple and compact structure on the FR-4 substrate material. The proposed design initially has a meager antenna gain and bandwidth. To increase the antenna bandwidth and gain, the defective ground structure is implemented with four dumble-shaped slots. Parametric analysis is considered to find the radius of circular patch for tuning of UWB frequency applications. The proposed MCP antenna resonates at 2.9 GHz, 9.1 GHz frequencies with a S11 of − 34.84 dB, − 33.74 dB, respectively, and achieves 8.1 GHz (2.5–10.6 GHz) impedance bandwidth concerning the − 10 dB reference line of the reflection coefficient. The gains are 8.4 dBi, 8.2 dBi for the two resonant frequencies, and the radiation patterns are semi-omnidirectional, omnidirectional. The proposed antenna has-been validated by observing good agreement between the simulation and the measured results.
Reassessment of the flexural behavior of high-strength reinforced concrete beams under short-term loads
Authors: Tamayo Jorge Luis Palomino , Garcia Gabriel Orso 
Published: January 2021

AbstractThis work aims at describing the behavior of high-strength reinforced concrete (HSRC) beams under short-term ultimate loads with concrete compressive strengths higher than 50 MPa. A plastic approach besides a cross sectional analysis is employed to primarily trace the nonlinear response of nineteen HSRC simply supported beams for which experimental results are available. This proposed theoretical approach is able to acceptably match the experimental data with minor overestimation of flexural moments. Closed-form expressions to evaluate ductility indexes regarding deflections and curvatures as well as plastic rotation capacities are also proposed herein. Predictions of the National Brazilian Regulation for design of concrete structures NBR6118 in terms of ultimate flexural moments are also computed for comparison. A complete assessment of ductility in which plastic rotation capacities are computed for the studied beams is also given. It is found that the flexural ductility of a member could be increased with the use of high strength concrete. The use of a maximum tension steel ratio to guarantee a minimum flexural of ductility is highlighted.
Needle and Biopsy Robots: a Review
Authors: Siepel Françoise J. , Maris Bogdan , Welleweerd Marcel K. , Groenhuis Vincent , Fiorini Paolo , Stramigioli Stefano 
Published: January 2021

Abstract
Purpose of the review
Robotics is a rapidly advancing field, and its introduction in healthcare can have a multitude of benefits for clinical practice. Especially, applications depending on the radiologist’s accuracy and precision, such as percutaneous interventions, may profit. This paper provides an overview of recent robot-assisted percutaneous solutions.

Recent findings
Percutaneous interventions are relatively simple and the quality of the procedure increases a lot by introducing robotics due to the improved accuracy and precision. The success of the procedure is heavily dependent on the ability to merge pre- and intraoperative images, as an accurate estimation of the current target location allows to exploit the robot’s capabilities.

Summary
Despite much research, the application of robotics in some branches of healthcare is not commonplace yet. Recent advances in percutaneous robotic solutions and imaging are highlighted, as they will pave the way to more widespread implementation of robotics in clinical practice.
Quantifying the Non-Use Value of Biodiversity in Cost–Benefit Analysis: The Dutch Biodiversity Points
Authors: Bos Frits , Ruijs Arjan 
Published: January 2021

AbstractBiodiversity points are a quantitative measure for biodiversity. For over a decade, biodiversity points are being applied in the Netherlands for measuring the impact of roads, enclosure dams, and other water management projects on the non-use value of biodiversity. Biodiversity points are quite similar to the quality-adjusted life years used for cost-effectiveness analysis of healthcare treatments. Biodiversity points can be calculated by multiplying the size of the ecotope (e.g., number of hectare), the ecological quality of the ecotope (0–100 %), and the ecological scarcity of each type of ecotope. For many infrastructure projects, the impact on the non-use value of biodiversity can be a principal purpose or a major co-benefit or trade-off, for example, for a park, a fish sluice, a road, an ecoduct, an enclosure dam, or a marine protected area. Biodiversity points are a simple, transparent, and standardized way to aggregate and quantify the qualitative or ordinal assessments by ecological experts. For measuring the non-use value of biodiversity, they are also more informative than valuation by revealed or stated preferences methods. This paper provides the first overview of the application of this method in the Dutch practice of cost–benefit analysis. It also discusses its merits and limitations. The calculation and use of biodiversity points are illustrated by four case studies.
Modifying laboratory testing via home brew during the COVID-19 pandemic
Authors: Moran Jeffery H. , Kessler Larry , Moylan Jennifer , Forrest Craig , Boehme Karl , Kennedy Josh , Greninger Alex , Baird Geoff , Olgaard Ericka , James Laura 
Published: January 2021

AbstractRapid development and deployment of diagnostic testing for COVID-19 have been a key component of the public health response to the pandemic. Out of necessity, academic and other clinical laboratories developed laboratory testing innovations for COVID-19 to meet clinical testing demands. In addition to constraints on local testing supplies and equipment, a rapidly changing regulatory framework created challenges for translational scientists. Illustrative examples of approaches used to develop laboratory tests during the early stages of the COVID-19 pandemic demonstrate effective team science approaches to this challenging clinical care and public health emergency. These experiences and the associated lessons learned are relevant to the development of public health response plans for future pandemics.
Coronavirus disease 2019 (COVID-19) research agenda for healthcare epidemiology
Authors: Mody Lona , Akinboyo Ibukunoluwa C. , Babcock Hilary M. , Bischoff Werner E. , Cheng Vincent Chi-Chung , Chiotos Kathleen , Claeys Kimberly C. , Coffey K. C. , Diekema Daniel J. , Donskey Curtis J. , Ellingson Katherine D. , Gilmartin Heather M. , Gohil Shruti K. , Harris Anthony D. , Keller Sara C. , Klein Eili Y. , Krein Sarah L. , Kwon Jennie H , Lauring Adam S. , Livorsi Daniel J. , Lofgren Eric T. , Merrill Katreena , Milstone Aaron M. , Monsees Elizabeth A. , Morgan Daniel J. , Perri Luci P. , Pfeiffer Christopher D. , Rock Clare , Saint Sanjay , Sickbert-Bennett Emily , Skelton Felicia , Suda Katie J. , Talbot Thomas R. , Vaughn Valerie M. , Weber David J. , Wiemken Timothy L. , Yassin Mohamed H. , Ziegler Matthew J. , Anderson Deverick J. 
Published: January 2021

AbstractThis SHEA white paper identifies knowledge gaps and challenges in healthcare epidemiology research related to coronavirus disease 2019 (COVID-19) with a focus on core principles of healthcare epidemiology. These gaps, revealed during the worst phases of the COVID-19 pandemic, are described in 10 sections: epidemiology, outbreak investigation, surveillance, isolation precaution practices, personal protective equipment (PPE), environmental contamination and disinfection, drug and supply shortages, antimicrobial stewardship, healthcare personnel (HCP) occupational safety, and return to work policies. Each section highlights three critical healthcare epidemiology research questions with detailed description provided in supplementary materials. This research agenda calls for translational studies from laboratory-based basic science research to well-designed, large-scale studies and health outcomes research. Research gaps and challenges related to nursing homes and social disparities are included. Collaborations across various disciplines, expertise and across diverse geographic locations will be critical.