bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Fitokimia dan Aktivitas Antibakteri Beberapa Jenis Tanaman terhadap Bakteri Patogen pada Budidaya Ikan
Authors: Salosso Yuliana , Olga Olga , Aisiah Siti , Ressie Jeny Dorotea , Foes Yenni Welhelmina , Pasaribu Wesley 
Published: November 2021

Penelitian ini bertujuan untuk mengetahui kandungan fitokimia serta aktivitas antibakteri sepuluh jenis tanaman terhadap bakteri Vibrio alginolyticus dan Aeromonas hydropilla. Dipilih 10 jenis tanaman yang sering digunakan sebagai obat dan banyak ditemukan di kota Kupang seperti tanaman Phyllanthus acidus, Euphorbia hirta, Persea gratissima, Euphorbia thymifolia, Morus australis, Justica gendarussa, Paederia scandeus, Annona squamosa, Sesbania sesban, dan Jatropha gossypifolia. Bagian tanaman yang digunakan adalah daun, kecuali E. hirta dan E. thymifolia digunakan seluruh bagian tanaman. Kesepuluh jenis tanaman tersebut dibuat bubuk, kemudian diekstraksi dengan cara dimaserasi secara bertingkat mulai dari pelarut n-heksan, etil asetat dan metanol, selain itu, juga digunakan ekstrak air tanaman tersebut. Semua jenis ekstrak tanaman diuji antibakteri dengan menggunakan metode cakram. Jenis ekstrak yang aktif selanjutnya diuji antibakteri pada konsentrasi 10%, 1% dan 0,1%. Hasil penelitian menunjukkan bahwa jenis tanaman yang berpotensi sebagai antibakteri pada budidaya ikan laut adalah esktrak air dan metanol E. hirta dan E. thymifolia. Sedangkan jenis tanaman yang berpotensi sebagai antibakteri pada budidaya ikan air tawar adalah ekstrak air E. hirta dan E. thymifolia daun J. gendarussa.
PENEMPATAN SDM POLRI MENUJU PERSONIL YANG PROFESIONAL PADA KEPOLISIAN DAERAH PROVINSI SULAWESI TENGGARA
Authors: Amrullah Amrullah , Suaib Eka , Yusuf Muhammad 
Published: November 2021

Penelitian ini bertujuan menganalisis penempatan sumber daya manusia Polri, menganalisis profesionalisme personil Polri dan mendeskripsikan faktor-faktor yang mempengaruhi penempatan sumber daya manusia Polri pada Kepolisian Daerah Provinsi Sulawesi Tenggara, Penelitian ini menggunakan pendekatan deskriptif kualitatif menggunakan teknik analisis model interaktif terdiri dari pengumpulan data, reduksi data, penyajian data dan penarikan kesimpulan/verivikasi, Hasil penelitian menunjukan penempatan sumber daya manusia Polri secara umum masih belum maksimal dan belum konsisten menerapkan prinsip meryt system dalam penyelenggaraan promosi, mutasi dan demosi personel, secara prosedural penempatan personel telah dilaksanakan dengan memperhatikan segala ketentuan pedoman/petunjuk yang tertuang PerkaPolri, namun masih ada tendensi terjadinya tindakan afirmatif yang berkembang dalam pelaksanaanya. Profesionalisme personil Polri dapat dikatakan cukup baik, anggota personel telah mempunyai keterampilan tinggi dalam suatu bidang ,mempunyai ilmu & pengetahuan sesuai dengan pendidikan & pelatihan kejuruan mencakup keahlian teknik, taktik, strategi, maupun manajemen yang didukung dengan pertanggung jawaban administrasi sesuai dengan jenis bentuk dan tatarannya, mempunyai sikap yang berorientasi ke depan dengan melakukan pemantapan terhadap fungsi mitigasi dan penegakan hukum menyikapi empat jenis kejahatan (konvensional, transnasional,kekayaan negara, dan kejahatan berimplikasi kontijensi) , telah mempunyai sikap mandiri dengan cukup baik dalam melakasanakan tugas & fungsi kepolisian baik fungsi utama, fungsi operasional, fungsi organik, dan fungsi pendukung Polri lainya. Kata Kunci: Penempatan SDM, Profesional Polri, Polda Sultra
PENGEMBANGAN KEMAMPUAN SUMBERDAYA APARATUR DI SEKRETARIAT DAERAH KABUPATEN KOLAKA
Authors: Suryandi Endang , Suaib Eka , Utha Arifin 
Published: November 2021

Penelitian ini bertujuan untuk menganalisis Pelaksanaan Pengembangan Kemampuan Sumberdaya Aparatur Pegawai Negeri Sipil di Sekretariat Daerah Kabupaten Kolaka. Penelitian ini menggunakan pendekatan kualitatif dengan informan sebanyak 9 orang yang ditentukan secara purposive sampling. Data dalam penelitian ini diperoleh melalui wawancara dan studi dokumentasi, data yang diperoleh ini kemudian analisis secara kualitatif melalui analisis data interaktif yang terdiri dari reduksi data, penyajian data serta penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa Pelaksanaan pengembangan Sumberdaya Aparatur di Sekretariat Daerah Kabupaten Kolaka, baik melalui pendidikan formal maupun non formal, perlu mendapat perhatian yang serius dari Pemerintah Daerah Kabupaten Kolaka, khususnya dukungan dari pimpinan Sekretariat Daerah Kabupaten Kolaka untuk melakukan diplomasi terutama terkait dengan kuota peserta tugas belajar, dan diklat serta peningkatan anggaran untuk kegiatan pengembangan kemampuan sumberdaya aparatur di Sekretariat Daerah Kabupaten Kolaka.Kata Kunci: Pengembangan Kemampuan, Sumberdaya Aparatur Sipil Negara, Pendidikan Latihan
Gambaran Kelelahan Kerja Karyawan PT Paving Meriba Jaya Kelurahan Tavanjuka Kota Palu
Authors: Politon Fellysca Veronica Margareth , Christine Christine 
Published: November 2021

Kelelahan kerja merupakan salah satu permasalahan keselamatan dan kesehatan kerja yang dapat menjadi faktor risiko terjadinya kecelakaan kerja dan dapat berdampak terhadap penurunan produktivitas kerja dan penurunan konsentrasi kerja. Di Kota Palu terdapat tiga Pabrik Paving Yaitu PT. Supplier Paving Batako Press Kanstin, PT. Watu Meriba Jaya, dan PT. Batu Split Palu. PT. Watu Meriba Jaya memiliki jumlah pekerja dengan jumlah total pekerja 38 orang yang terbagi pada divisi pencampuran, pencetakan, pengeringan, inising (penghalusan produk), serta pembuatan behel dan driver. Tujuan penelitian ini adalah diketahuinya Gambaran kelelahan kerja karyawan di PT. Watu Meriba Jaya Kelurahan Tavanjuka Kota Palu. Metode dalam penelitian ini adalah deskriptif dengan. Sampel penelitian ini adalah 38 karyawan. Data diolah dengan Analisa Univariate untuk menampilkan gambaran kelelahan kerja karyawan PT.Watu Meriba Jaya Tavanjuka Kota palu dan disajikan dalam bentuk tabel dan narasi. Hasil penelitian ini menunjukan bahwa masa kerja terbanyak adalah masa kerja baru 32 orang (84,2%). status gizi terbanyak adalah status gizi normal 33 orang (86,8%) . Divisi kerja terbanyak yaitu percetakan 15 orang (39,5%)tingkat kelelahan tertinggi dengan kelelahan kerja terbanyak yaitu kelelahan kerja ringan 27 pekerja (71,1%) Diharapkan bagi pekerja yang terkait yang dapat menyebabkan kelelahan, agar mematuhi segalah aturan yang telah di tetapkan oleh perusahaan.
Kata Kunci : Kelelahan kerja
Pelatihan Budidaya Curcuma spp dan Pembuatan Olahan Minuman Kesehatan untuk Peningkatan Imunitas
Authors: Rantesigi Nirva , Sufyaningsi Ulfa , Agusrianto Agusrianto 
Published: November 2021

WHO menetapkan Corona Virus (nCoV-19) sebagai wabah pendemi global. Ancaman pandemic semakin besar ketika berbagai kasus menunjukkan penularan antar manusia (human to human transmission) pada petugas kesehatan yang merawat pasien, menyebabkan peningkatan jumlah kasus yang luar biasa hingga kasus terkonfirmasi covid 19 sampai Juni 2021 berjumlah 178.837.204. pada kelompok rentan dengan imunitas yang menurun rentan untuk tertular dan menderita infeksi Covid 19, peningkatan imunitas masyarakat penting untuk mencegah dan melawan infeksi. Tujuan kegiatan ini adalah untuk Memberikan pengetahuan dan keterampilan kepada masyarakat dalam membudidayakan dan mengolah curucuma sebagai salah satu minuman untuk meningkatkan imunitas tubuh. Metode kegiatan ini adalah pelatihan, pembuatan olahan minuman kesehatan dan pembuatan kebun Tanaman Obat Keluarga (TOGA). Hasil kegiatan yaitu meningkatnya pengetahuan tentang manfaat curcuma untuk imunitas, keluarga membuat kebun TOGA dan mampu membuat plahan dari bahan curcuma. Kesimpulan yaitu meningkatnya pengetahuan dan keterampilan masyarakat dalam budidaya dan pengolahan curcuma menjadi minuman kesehatan. Saran bagi petugas kesehatan untuk rutin memberikan pendampingan kepada masyarakat dalam upaya peningkatan imunitas fisik seperti penggunaan bahan alam dimasa pandemi covid.
Diabetes Mellitus as a Risk Factor for Trigger Finger –a Longitudinal Cohort Study Over More Than 20 Years
Authors: Löfgren Jin Persson , Zimmerman Malin , Dahlin Lars B. , Nilsson Peter M. , Rydberg Mattias 
Published: November 2021

Background and AimTrigger finger (TF) or stenosing tenosynovitis has been associated with diabetes mellitus (DM), although today’s knowledge is mostly based on cross-sectional and case-control studies. Thus, the aim of the present population-based cohort study over more than 20 years was to investigate DM as a risk factor for TF.MethodsData from Malmö Diet and Cancer Study (MDCS), including 30,446 individuals, were analysed with regards to baseline DM and known or potential confounders. Information regarding TF diagnosis until study end date of Dec 31st, 2018, was retrieved from the Swedish National Patient Register (NPR) using ICD-codes. Survival probability was investigated in Kaplan-Meier plots. Cox proportional hazard regression model was used to evaluate DM as risk factor for TF, adjusted for several confounders and presented as Hazard Ratio (HR) with 95% confidence intervals (CI).ResultsAt baseline, 4.6% (1,393/30,357) participants had DM. In total, 3.2% (974/30,357) participants were diagnosed with TF during the study period. Kaplan-Meier plot showed that the probability for incident TF was significantly higher in participants with baseline DM compared with individuals without baseline DM. Adjusted HR for DM as risk factor for TF was 2.0 (95% CI: 1.5-2.6, p&lt;0.001).ConclusionThis longitudinal study showed that DM is an important risk factor for developing TF. When adjusting for sex, age, BMI, manual work, statin use, smoking and alcohol consumption, DM remained the main risk factor for TF.
Identification of Immune-Related Genes for Establishment of Prognostic Index in Hepatocellular Carcinoma
Authors: Li Yinfang , Zou Ling , Liu Xuejun , Luo Judong , Liu Hui 
Published: November 2021

Background: Immune checkpoint inhibitor (ICI) therapy has been proved to be a promising therapy to many types of solid tumors. However, effective biomarker for estimating the response to ICI therapy and prognosis of hepatocellular carcinoma (HCC) patients remains underexplored. The aim of this study is to build a novel immune-related prognostic index based on transcriptomic profiles.Methods: Weighted gene co-expression network analysis (WGCNA) was conducted to identify immune-related hub genes that are differentially expressed in HCC cohorts. Next, univariate Cox regression analysis and least absolute shrinkage and selection operator (LASSO) analysis were used to detect hub genes associated to overall survival (OS). To validate the immune-related prognostic index, univariate and multivariate Cox regression analysis were performed. CIBERSORT and ESTIMATE were used to explore the tumor microenvironment and immune infiltration level.Results: The differential expression analysis detected a total of 148 immune-related genes, among which 25 genes were identified to be markedly related to overall survival in HCC patients. LASSO analysis yielded 10 genes used to construct the immune-related gene prognostic index (IRGPI), by which a risk score is computed to estimate low vs. high risk indicating the response to ICI therapy and prognosis. Further analysis confirmed that this immune-related prognostic index is an effective indicator to immune infiltration level, response to ICI treatment and OS. The IRGPI low-risk patients had better overall survival (OS) than IRGPI high-risk patients on two independent cohorts. Moreover, we found that IRGPI high-risk group was correlated with high TP53 mutation rate, immune-suppressing tumor microenvironment, and these patients acquired less benefit from ICI therapy. In contrast, IRGPI-low risk group was associated with low TP53 and PIK3CA mutation rate, high infiltration of naive B cells and T cells, and these patients gained relatively more benefit from ICI therapy.
Recent Advances in Presentation, Diagnosis and Treatment for Mixed Vaginitis
Authors: Qi Wenhui , Li Huanrong , Wang Chen , Li Huiyang , Zhang Bingbing , Dong Mengting , Fan Aiping , Han Cha , Xue Fengxia 
Published: November 2021

Mixed vaginitis is the simultaneous presence of at least two types of vaginitis, contributing to an abnormal vaginal milieu and leading to vaginal symptoms and signs. However, associations between symptoms and the type of mixed vaginitis have not been clearly elucidated, and research on mixed vaginitis is still in the preliminary stage. Therefore, the pathogenic mechanism of mixed vaginitis remains understudied. Mixed vaginitis generally involves the formation of mixed biofilms. The study of polymicrobial interactions and mixed biofilms will provide a new idea for the understanding of mixed vaginitis. Moreover, this review summarizes some effective management and laboratory diagnosis of mixed vaginitis to avoid inappropriate therapy, recurrence, and reinfection. It is of high clinical importance to obtain relevant clinical data to improve clinical knowledge about mixed vaginitis.
Coding Variation and Adherence to Methodological Standards in Cardiac Research Using the National Inpatient Sample
Authors: Ostrominski John W. , Amione-Guerra Javier , Hernandez Brian , Michalek Joel E. , Prasad Anand 
Published: November 2021

Background: Code selection is crucial to the accuracy and reproducibility of studies using administrative data, however a comprehensive assessment of coding trends for major cardiac diagnoses and procedures is lacking. We aimed to evaluate trends in administrative code utilization for major cardiac diagnoses and procedures, and adherence to required methodological practices in cardiac research using the National Inpatient Sample (NIS).Methods: In this observational study of 445 articles, ICD-9-CM codes corresponding to acute myocardial infarction (AMI), heart failure, atrial fibrillation, percutaneous coronary intervention, and coronary artery bypass grafting were collected and analyzed. The NIS was used to compare the number of hospitalizations between the most frequently encountered AMI case definitions. Key elements were abstracted from each article to evaluate adherence to required methodological practices.Results: Variation in code utilization was observed for each diagnosis and procedure assessed, and the number of unique case definitions published per year increased throughout the study period (P &lt; 0.001), driven largely by the significant increase in articles per year (P &lt; 0.001). Off-target codes were observed in 39 (8.8%) studies. Upon reintroduction into the NIS for 2008–2012, the most commonly encountered case definitions for AMI were found to yield significantly different estimates of AMI hospitalizations and hospitalization trends over time. Three hundred and ninety-nine articles (84%) did not adhere to one or more required research practices. Overall adherence was superior for publications in higher-impact journals (P = 0.002).Conclusions: Substantial variation in code selection exists for major cardiac diagnoses and procedures, and non-adherence to methodological standards is widespread. These data have important implications for the accuracy and generalizability of analyses using the NIS.
Omentin-1 Modulates Macrophage Function via Integrin Receptors αvβ3 and αvβ5 and Reverses Plaque Vulnerability in Animal Models of Atherosclerosis
Authors: Lin Xuze , Sun Yan , Yang Shiwei , Yu Mengyue , Pan Liu , Yang Jie , Yang Jiaqi , Shao Qiaoyu , Liu Jinxing , Liu Yan , Zhou Yujie , Wang Zhijian 
Published: November 2021

Backgrounds: Omentin-1 is a novel cytokine that is primarily released by the epicardial adipose tissue. Molecular structure analysis revealed that it contained a fibrinogen-like domain. Clinical studies have demonstrated that the expression of omentin-1 is tightly associated with the development of cardiovascular diseases, but the receptor by which omentin-1 modulates macrophage function has not been identified yet.Objective: This study sought to investigate the effect of omentin-1 on already-established atherosclerosis (AS) lesions in both ApoE−/− and Ldlr−/− mice and further, study its underlying mechanisms.Methods and Results: We investigated the effect of omentin-1 on the plaque phenotype by implanting a minipump in ApoE−/− and Ldlr−/− mice. In vivo studies showed that the infusion of omentin-1 increased the collagen content and mitigated the formation of the necrotic core in both animal models. Immunohistochemistry and immunofluorescence analysis revealed that omentin-1 suppressed inflammatory cytokines expression, macrophage infiltration, and apoptosis within the plaque. An immunoprecipitation experiment and confocal microscopy analysis confirmed the binding of omentin-1 to the integrin receptors αvβ3 and αvβ5. The cell studies demonstrated that omentin-1 suppressed the apoptosis and inflammatory cytokines expression induced by the oxidized low-density lipoprotein in the macrophage. In addition, omentin-1 promoted the phosphorylation of the integrin-relevant signaling pathway as well as the Akt and AMPK in the macrophage. The addition of the inhibitor of the integrin receptor or interfering with the expression of the integrin subunit αv (ITGAV) both significantly abrogated the bioeffects induced by omentin-1. A flow cytometry analysis indicated that the antibodies against αvβ3 and αvβ5 had a competitive effect on the omentin-1 binding to the cell membrane.Conclusions: The administration of adipokine omentin-1 can inhibit the necrotic cores formation and pro-inflammatory cytokines expression within the AS lesion. The mechanisms may include the suppression of apoptosis and pro-inflammatory cytokines expression in the macrophage by binding to the integrin receptors αvβ3 and αvβ5.
Knowledgeability, Attitude and Practice Behaviors of Dental Providers Toward Provisions of Integrated Care Delivery for Patients With Prediabetes/Diabetes: Wisconsin Statewide Survey
Authors: Shimpi Neel , Panny Aloksagar , Glurich Ingrid , Chyou Po-Huang , Acharya Amit 
Published: November 2021

Introduction: To conduct a statewide survey among Wisconsin-based dental providers evaluating current knowledgeability, attitudes and practice behaviors surrounding management of patients with diabetes/prediabetes in the dental setting. The study explored perceptions on feasibility, value, barriers, and current status of integrated care model (ICM) adoption by dental practicesMaterials and Methods: A 32-question paper-based survey was mailed to all licensed dentists and dental hygienists practicing in Wisconsin. The study was conducted over a 4 week period in 2019. The survey instrument was adapted from a previous validated survey and was expanded to include questions on ICM adoption. Content and validity analyses and beta testing were conducted prior to dissemination of the survey. Descriptive statistics and chi-square tests were applied for data analyses. Thematic analyses was performed on open-ended questions.Results: Survey response rate was 12% (N = 854/7,356) representing 41% dentists and 59% dental hygienists. While 68% reported educating patients on oral health-diabetes association, only 18% reported medical consultations to inform dental treatment, and “frequent” (22%) or “occasional” (40%), medical triage. Knowledge-based questions were correctly answered by &gt;70% of participants. While 50% valued chair-side glycemic screening and 85% supported non-invasive chair-side screening to identify at-risk patients,&gt;88% relied on patient-reported diabetic status. Barriers to ICM adoption included time investment (70%), patient activation/cooperation (62%), cost (50%), insurance coverage (50%), infrequent interdisciplinary communication (46%), lack of equipment (33%) and provider (31%).Conclusion: Low rates of ICM adoption, chair-side testing, medical consultation and triage, and need for educational curricula reform were identified.
Optogenetic Activation of Arcuate Kisspeptin Neurons Generates a Luteinizing Hormone Surge-Like Secretion in an Estradiol-Dependent Manner
Authors: Lin Xian-Hua , Lass Geffen , Kong Ling-Si , Wang Hui , Li Xiao-Feng , Huang He-Feng , O’Byrne Kevin T. 
Published: November 2021

Traditionally, the anteroventral periventricular (AVPV) nucleus has been the brain area associated with luteinizing hormone (LH) surge secretion in rodents. However, the role of the other population of hypothalamic kisspeptin neurons, in the arcuate nucleus (ARC), has been less well characterized with respect to surge generation. Previous experiments have demonstrated ARC kisspeptin knockdown reduced the amplitude of LH surges, indicating that they have a role in surge amplification. The present study used an optogenetic approach to selectively stimulate ARC kisspeptin neurons and examine the effect on LH surges in mice with different hormonal administrations. LH level was monitored from 13:00 to 21:00 h, at 30-minute intervals. Intact Kiss-Cre female mice showed increased LH secretion during the stimulation period in addition to displaying a spontaneous LH surge around the time of lights off. In ovariectomized Kiss-Cre mice, optogenetic stimulation was followed by a surge-like secretion of LH immediately after the stimulation period. Ovariectomized Kiss-Cre mice with a low dose of 17β-estradiol (OVX+E) replacement displayed a surge-like increase in LH release during period of optic stimulation. No LH response to the optic stimulation was observed in OVX+E mice on the day of estradiol benzoate (EB) treatment (day 1). However, after administration of progesterone (day 2), all OVX+E+EB+P mice exhibited an LH surge during optic stimulation. A spontaneous LH surge also occurred in these mice at the expected time. Taken together, these results help to affirm the fact that ARC kisspeptin may have a novel amplificatory role in LH surge production, which is dependent on the gonadal steroid milieu.
Study on the Optimization of Filling Ratio and Strength Variation Characteristics of Cemented Backfills Containing Fly Ash
Authors: Chang Baomeng , Du Cuifeng , Chu Xiaofeng , Zhang Long 
Published: November 2021

The fly ash for underground filling can effectively utilize solid waste, improve the strength of the backfill, and reduce the cost, thus creating good social and economic benefits. Relying on the filling requirements of a gold mine in Jilin, this paper carried out the filling ratio experiments containing fly ash and analyzed the reasons for the variation of the backfill strength based on the hydration characteristics of cement and fly ash and scanning electron microscope. The results show that fly ash has an overall effect on the strength of the backfill, and the strength development is mainly concentrated in the period of 28–56 d; when the filling slurry contains tailings, the excessive amount of fly ash is likely to cause a large number of fine particles to obstruct the hydration of cementitious materials; when the concentration of the filling slurry is 74%, the cement content is 5%, the mass ratio of waste rock-tailings-fly ash is 6:2:3, and the CaO content is 6:3, the strength of the backfill is significantly higher than the current strength of the backfill of the mine, and the cost can be saved by RMB 0.56 per cubic meter; the strength characteristics of the backfill mainly depend on the pore structure; when the filling slurry is better matched, the cement and fly ash hydration generates a large number of C-S-H gel particles, which wraps the aggregate to form a dense structure with less pore structure, and the strength of the backfill increases; the strength variation process of backfill containing cement and fly ash is divided into cement hydration period, fly ash infiltration period, and slurry hardening period. To enhance the strength of the backfill, it is necessary to determine the appropriate cementitious material ratio to maximize the excitation of fly ash hydration during the fly ash infiltration period, and the hydration produces a gel structure with an excellent aggregate ratio. In addition, the slurry hardening reduces the porosity of the backfill. The results can provide basic data and theoretical guidance for further promotion and application of fly ash in mine filling.