bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review: The Efficacy of Curcumin in Cognitive Impairment
Authors: Fung Romi 
Published: October 2021

Background Dementia is a syndrome characterized by a progressive cognitive decline that can interfere with everyday function. The presence of inflammation is associated with the progression of cognitive decline. Treatment of inflammation-induced cognitive decline has been proposed through the use of anti-inflammatories. One intervention studied is curcumin, a compound extracted from the spice turmeric with anti-inflammatory properties. This paper reviews the efficacy of curcumin in cognitive decline.
Purpose This review seeks to understand how effective curcumin is an intervention for optimizing cognition in older adults ages 55 and older compared to placebo. This study will benefit the naturopathic doctor investigating curcumin's current literature and its efficacy in treating cognitive decline.
Methods A literature search was conducted in accordance with literature review methods. Using the keywords [curcumin OR turmeric] AND [Alzheimer's disease OR dementia], a preliminary search for relevant articles on this topic was conducted on MEDLINE, PubMed, CINAHL, Embase and Cochrane databases screened for article titles containing dementia, Alzheimer's disease and curcumin, and filtering for articles published from 2000 onward and in English.
Results Six studies were found eligible after considering inclusion and exclusion criteria. Of these studies, four of them have shown positive cognition improvements, and two studies have shown no improvement in cognition.
Implications Curcumin may have potential as an intervention for the treatment of cognitive decline. However, due to insufficient studies, more research is warranted to understand better if curcumin is beneficial as an adjunctive treatment for Alzheimer's disease.
Key Messages

Inflammation plays a potential role in Alzheimer's disease. Curcumin is a compound extracted from the spice turmeric and possesses anti-inflammatory properties.
Curcumin may be a potential adjuvant in treating mild cognitive impairment, but likely not for those diagnosed with dementia.
Future research on curcumin use is needed to better address and understand its efficacy on individuals living with mild cognitive impairment and dementia.
MODEL PEMBELAJARAN PROBLEM SOLVING DI PONDOK PESANTREN
Authors: Khalifaturohma Siti Hajah , Mufida Zahrotul 
Published: October 2021

The Islamic Boarding School is the oldest education institution in Indonesia. It doesn’t hold on firmly to the classical method. But. It also follows the development. Until the emergence terminology of modern Islamic Boarding School. Including It’s learning model which has followed to era development. But. It still maintains the Islamic Boarding School’s values. One is problem solving earning model. The discussion this time will talk over related to problem solving as the authentic concept and tried to be compared with the Islamic Boarding school problem solving that’s called bahtsul masail. The result of discussion indicates that bahtsul masa’il is more classic than problem solving. But. bahstul masa’il provides the problem solving more complex. It doesn’t just based on the logical law. But also it must basically principled to Al Quran and Hadist and other instinbat methods.
TEACHING ENGLISH USING GOOGLE CLASSROOM AS MEDIA AT MTs ARROHMAN JOMBANG
Authors: Khudriyah Khudriyah 
Published: October 2021

The goal of learning English in junior high school is students can reach the functional level, namely communicating orally and in writing to solve daily problems. This research aimed to describe how teaching English using Google classroom at MTs arrohman Jombang. The research method is qualitative descriptive, interview and observation as instrument. The data then analysed by Miles & Huberman model. The result are: The process of teaching and learning English: deciding learning objectives, materials, media, and evaluation of all components. The learning objectives were in accordance with the indicators contained in the curriculum. The material conveyed to students were: understanding, function, and application of the past tense in sentences. Using media of power point, pictures, and sheet of students work. The learning method used was questions and answers; the strategy used based on on the students’ condition. And the evaluation results dit not achieve the criteria of success. Those students who were able to reach the criterion was only 50% from A class, and 34% from B class.
Taxonomic revision of the Deltohyboma Lane, 1946 gilli species group (Coleoptera: Scarabaeidae: Scarabaeinae: Deltochilum)
Authors: González-Alvarado Arturo , Vaz-de-Mello Fernando Z. 
Published: October 2021

The dung beetles belonging to the genus Deltochilum Eschscholtz, 1822 are widely distributed in the Neotropical region. This genus is divided into eight subgenera, of these, the subgenus Deltohyboma Lane, 1946 is the most diverse, with an estimated 212 species. The most recent revision of Deltohyboma divided the subgenus into 19 species group. Here, taxonomy of the gilli species group is revised. Four new species (D. jocelynae sp. nov., D. nonstriatum sp. nov., D. quasistriatum sp. nov. and D. tenuistriatum sp. nov.) are described, making a total of five species within the species group. Keys for species identification and habitus as well as male genitalia morphology are illustrated.
Priority Assessment of Key Factors of IMO-MSC/Circular.834 for Ship Engine Room Safety and Efficiency Based on Human Aspects
Authors: Ölmez Hasan , Bastürk Selim , Çolak Köksal 
Published: October 2021

International Maritime Organization (IMO) has published technical circular (MSC/Circular. 834) including nonmandatory guidelines with five main criteria about engine room layout, design, and arrangement. The purpose of this study is to present the most important priority criteria of seafarers about engine room design according to the criteria from IMO MSC/Circular.834 guidelines. Since there are no obligations, the priority and importance of these criteria are not clearly emphasized. Therefore, the determination of seafarers’ priorities for arrangement in terms of safety and efficiency become important to make decision. For this, fuzzy Analytic Hierarchy Process (AHP) technique, which is one of the most used fuzzy Multiple Criteria Decision Making (MCDM)methods is employed.

Introduction
Maritime transportation, known for oldest and widespread transportation around the world, with 11 billion tons weight and 80% rate of world trade volume (UNCTAD 2019). Maritime transportation has many components and one of the most important and effective parts of these components are ships and seafarers. Because of the difficulty of ship conditions, ships should be present optimum working conditions for seafarers in order to achieve effective and safe operations on board. At the present time, there are previous studies about the difficulty of working studies on board. It is a scientific and cultural fact that seafarers are under higher risk of working conditions comparing to other jobs (Bloor et al. 2000; Havold 2005; Hetherington et al. 2006; Mallam et al. 2015). Due to this reason, International Maritime Organization (IMO) has made various regulations for years in order to improve seafarers’ safety and efficiency on board. One of the goals of these regulations is to design optimum working conditions on board for seafarers. Based on complex structure and having various danger conditions, engine room design is considerable to ensure safety and efficiency for engine room department seafarers.
An “Outer Piezoelectric and Inner Epigenetic” Logic‐Gated PANoptosis for Osteosarcoma Sono‐Immunotherapy and Bone Regeneration
Authors: Wang Xiaoting , Guo Xun , Ren Hongze , Song Xinran , Chen Liang , Yu Luodan , Ren Jianli , Chen Yu 
Published: December 2024

AbstractThe precise manipulation of PANoptosis, a newly defined cell death pathway encompassing pyroptosis, apoptosis, and necroptosis, is highly desired to achieve safer cancer immunotherapy with tumor‐specific inflammatory responses and minimal side effects. Nonetheless, this objective remains a formidable challenge. Herein, an “AND” logic‐gated strategy for accurately localized PANoptosis activation, utilizing composite 3D‐printed bioactive glasses scaffolds integrated with epigenetic regulator‐loaded porous piezoelectric SrTiO3 nanoparticles is proposed. The “logic‐gated” strategy is co‐programmed by an “outer” input signal of exogenous ultrasound irradiation to produce reactive oxygen species and an “inner” input signal of acid tumor microenvironment to ensure the epigenetic demethylation regulation, guaranteeing the tumor‐specific PANoptosis. Specifically, immunogenic PANoptosis triggers dendritic cell maturation and cytotoxic T cell activation, amplifying antitumor immune responses and significantly suppressing osteosarcoma growth, with a suppression rate of ≈73.47 ± 5.2%. In addition, the well‐known bioactivities of Sr‐doped scaffolds expedite osteogenic differentiation and reinforce bone regeneration. Therefore, this work provides a paradigm of logic‐gated sono‐piezoelectric biomaterial platform with concurrently exogenous/endogenous activated PANoptosis for controlled sono‐immunotherapy of osteosarcoma, and related bone defects repair.
Ultra‐Stiff yet Super‐Elastic Graphene Aerogels by Topological Cellular Hierarchy
Authors: Xia Yuxing , Qin Huasong , Tong Wenhao , Qi Yuxiang , Li Kaiwen , Liu Yingjun , Xu Zhen , Liu Yilun , Pang Kai , Gao Chao , Gao Weiwei 
Published: December 2024

AbstractLightweight cellular materials with high stiffness and excellent recoverability are critically important in structural engineering applications, but the intrinsic conflict between these two properties presents a significant challenge. Here, a topological cellular hierarchy is presented, designed to fabricate ultra‐stiff (>10 MPa modulus) yet super‐elastic (>90% recoverable strain) graphene aerogels. This topological cellular hierarchy, composed of massive corrugated pores and nanowalls, is designed to carry high loads through predominantly reversible buckling within the honeycomb framework. The compressive modulus of the as‐prepared graphene aerogel is nearly twice that of conventional graphene aerogel. This high‐stiff graphene aerogel also exhibits exceptional mechanical recoverability, achieving up to 60% strain recovery over 10 000 fatigue cycles without significant structural failure, outperforming most previously reported porous lattices and monoliths. It is further demonstrated that this graphene aerogel exhibits superior energy dissipation and anti‐fatigue dynamic impact properties, with an energy absorption capacity nearly an order of magnitude greater than that of conventional aerogels. These exceptional properties of the topological cellular graphene aerogel open new avenues for high‐energy bullet protection, offering great promise for the development of lightweight, armor‐like protective materials in transportation and aerospace applications.
On the inherent correlation between the fluidization and flow properties of cohesive powders
Authors: van der Sande P. Christian , Wu Kaiqiao , Kamphorst Rens , Wagner Evert C. , Meesters Gabrie M. H. , van Ommen J. Ruud 
Published: December 2024

AbstractIn this study, we investigate the correlation between fluidization behavior and flow properties of 10 commercially available cohesive powders through fluidization and rotating drum experiments. The rotating drum was operated at high speeds to aerate the powder, creating flow fields and stress conditions comparable to those in gas–solid fluidized beds. We introduce a fluidization quality index (FQI) computed from X‐ray imaging, which addresses the limitations of conventional analyses for assessing fluidization quality of cohesive powders. By analyzing flow patterns, the FQI integrates gas holdup and its temporal variation, providing a reliable measure of fluidization quality. The findings establish a positive correlation between flowability and fluidization quality, demonstrating how flowability measurements can predict the effectiveness of mechanical vibration in enhancing fluidization characteristics. These results suggest that fast, user‐friendly flowability assessments in a rotating drum can effectively predict fluidization potential, contributing to process optimization and advancing fluidization studies for cohesive powders.
Thermal performance of bio‐nanofluid dihydrolevoglucosenone: Experimental and atomistic simulation investigations
Authors: Das Nipu Kumar , Hussain Raghibul , Vatti Anoop Kishore , Banerjee Tamal 
Published: December 2024

AbstractThis work presents findings on using a bio‐nanofluid‐containing Cyrene as a potential bio‐organic thermal base fluid. The fluid thermal properties can be enhanced with 0.03 vol% carboxylic functionalized multiwalled carbon nanotube (MWCNT‐COOH) to boost its heat transfer capabilities. The study compares the findings with the commercially available heat transfer fluids, that is, Paratherm GLT and Therminol 55. Furthermore, the stability of the nanofluid was assessed using experiments and atomistic simulation. Additionally, thermophysical characteristics such as thermal conductivity, density, viscosity, and specific heat () were measured. The thermal conductivity at various weight percentages of nanoparticles was determined using the reverse non‐equilibrium molecular dynamics (NEMD) simulations and validated with experimental values. The microstructure of Cyrene on the surface of a single‐walled carbon nanotube (SWCNT) and SWCNT‐COOH was examined using density functional theory (DFT) calculations. Our study shows that the composition of CNTs and the nanofluid temperature significantly impact the thermal conductivity of pure Cyrene.
BN‐Acene Ladder with Enhanced Charge Transport for Organic Field‐Effect Transistors
Authors: Li Chenglong , Sun Yanan , Xue Ning , Guo Yongkang , Jiang Ruijun , Wang Yuanhui , Liu Yujian , Jiang Lang , Liu Xuguang , Wang Zhaohui , Jiang Wei 
Published: December 2024

AbstractThe in‐depth research on the charge transport properties of BN‐embedded polycyclic aromatic hydrocarbons (BN‐PAHs) still lags far behind studies of their emitting properties. Herein, we report the successfully synthesis of novel ladder‐type BN‐PAHs (BCNL1 and BCNL2) featuring a highly ordered BC3N2 acene unit, achieved via a nitrogen‐directed tandem C−H borylation. Single‐crystal X‐ray diffraction analysis unambiguously revealed their unique and compact herringbone packing structures. Micro‐sized single‐crystalline organic field‐effect transistors (OFETs) demonstrated that an enhanced charge transport capability, with BCNL2 achieving a hole mobility of up to 0.62 cm2 V−1 s−1–three orders of magnitude higher than that of BCNL1 (μhmax=6 × 10−4 cm2 V−1 s−1), ranking among the highest values for BN‐PAHs‐based OFETs. Detailed calculations attribute this significant enhancement in the hole mobility to the marked reduction in reorganization energy (λ) of BCNL2, resulting from the five‐membered pyrrole ring annulation and molecular skeleton elongation. This work provides insight into molecular design principles for potential BN‐PAHs in optoelectronic applications.
Strong Heteroatomic Bond‐Induced Confined Restructuring on Ir−Mn Intermetallics Enable Robust PEM Water Electrolyzers
Authors: Wang Shuang , Shi Yan , Shen Tao , Wang Guangzhe , Sun Yue , Wang Gongwei , Xiao Li , Yan Changfeng , Wang Chundong , Liu Hongfang , Wang Ying , Liao Honggang , Zhuang Lin , Wang Deli 
Published: December 2024

AbstractLow‐iridium acid‐stabilized electrocatalysts for efficient oxygen evolution reaction (OER) are crucial for the market deployment of proton exchange membrane (PEM) water electrolysis. Manipulating the in situ reconstruction of Ir‐based catalysts with favorable kinetics is highly desirable but remains elusive. Herein, we propose an atomic ordering strategy to modulate the dynamic surface restructuring of catalysts to break the activity/stability trade‐off. Under working conditions, the strong heteroatom‐bonded structure triggers rational surface‐confined reconstruction to form self‐stabilizing amorphous (oxy)hydroxides on the model Ir−Mn intermetallic (IMC). Combined in situ/ex situ characterizations and theoretical analysis demonstrate that the induced strong covalent Ir−O−Mn units in the catalytic layer weaken the formation barrier of OOH* and promote the preferential dynamic replenishment/conversion pathway of H2O molecules to suppress the uncontrollable participation of lattice oxygen (about 2.6 times lower than that of pure Ir). Thus, a PEM cell with Ir−Mn IMC as anode “pre‐electrocatalyst” (0.24 mgIr cm−2) delivers an impressive performance (3.0 A cm−2@1.851 V@80 °C) and runs stably at 2.0 A cm−2 for more than 2,000 h with the cost of USD 0.98 per kg H2, further validating its promising application. This work highlights surface‐confined evolution triggered by strong heteroatom bonds, providing insights into the design of catalysts involving surface reconstruction.
Exploring the Impact of Irrigation on Chinaʼs Crop TFP: Insights From a Structural Break Analysis
Authors: Zhou Tiantian , Liu Xingshuo , Jia Siying , Sheng Yu 
Published: December 2024

ABSTRACTInvesting in agricultural infrastructure, particularly irrigation systems, is crucial for enhancing agricultural productivity and fostering rural development in developing countries. This study evaluates the impact of irrigation infrastructure investments on total factor productivity (TFP) in Chinaʼs crop industry from 1980 to 2018, and also estimates their economic returns across different sub‐periods. We employ a fixed‐effects instrumental variables (FE‐IV) regression model combined with a structural break analysis on provincial‐level data to establish the causal relationship between irrigation investments and TFP growth. The findings reveal that irrigation infrastructure investments have significantly improved TFP in Chinaʼs crop industry over the period, though the marginal returns declined in the last decade. The average internal rate of return for irrigation investments during 2002–2018 is estimated at 11.5%, which is below the long‐term trend of 19.3%. This suggests potential over‐investment or inefficient allocation of resources in recent years, highlighting the need for better optimisation of public investment to sustain productivity gains in agriculture.
Expression Variations of Chloride Ion Channel Related Genes During Diapause Termination in Silkworm, Bombyx mori
Authors: Chen Feifei , Qiu Guoxiang , Sun Jingchen , Yan Huichao , Feng Shizhang , Li Hanbo , Zhong Yangsheng , Han Mingke , Lin Jiangrong , Uddin Memon Fareed , Tian Ling , Li Wenchu 
Published: December 2024

ABSTRACTInstant and refrigerated acid soaking are commonly used in cocoon production to prevent or break diapause, and provide developable silkworm eggs for sericulture, while their mechanisms have not been fully understood. This study aims to investigate the mechanisms by which hydrochloric acid (HCl) or dimethyl sulfoxide (DMSO) promotes embryonic development in silkworm Bombyx mori, focusing on the chloride ion (Cl−) related gene expression profiles. Our results revealed that the HCl treatment of up to 6 min enhanced hatchability in freshly picked and cold‐stored eggs, whereas a slight decrease in hatchability was observed in those treated with DMSO for 40 min. The genes encoding chloride ion channel proteins were cloned and transcriptionally analyzed by quantitative real‐time PCR in B. mori 932 strain. Bioinformatics analysis showed that BmCLIC, BmGluCl, and Bmγ‐Cl mainly clustered with Lepidopteran insect homologs, while there existed a relatively low conservation from B. mori to mammals. We further explored the mRNA levels of BmCLIC, BmGluCl, and Bmγ‐Cl in different egg processing conditions and embryonic developmental stages following HCl or DMSO treatments. Our results revealed that the mRNA expression profiles of BmCLIC, BmGluCl, and Bmγ‐Cl increased in 20 h post‐egg oviposition and refrigerated eggs after acid soaking. Moreover, the relative expression level of BmCLIC and BmGluCl gene was the highest on the first day, and maximum relative expression level of Bmγ‐Cl gene presented on the second day in diapause eggs after treatment, and then it showed diversity. The expression profiles of the candidate genes seem like the same trend of changes during the development of eggs treated with instant acid soaking or DMSO treatment. In general, in the production practice of soaking silkworm eggs with HCl or DMSO, Cl− channel is likely to play an important subsidiary role to promot the relieving of diapause.
Beyond the blade: Unveiling the nexus of spirituality and human dissection among medical and allied health students in Nigeria
Authors: Okafor Izuchukwu Azuka , Nnaka Jude Amechi , Suleiman Muritala Odidi , Erekosima Boma Uriah , Mbagwu Smart Ikechukwu , Ibeabuchi Kingsley Chinemerem , Gbadegesin Ojo Stephen , Uzomba Godwin Chinedu , Aliyu Aliyu Isah 
Published: December 2024

AbstractThis study investigated how human dissection affects students' spiritual beliefs, and how their existing spiritual beliefs influence their perceptions of human dissection. This cross‐sectional study assessed 760 medical students with human dissection experience using an online questionnaire developed from interviews and the Spirituality Orientation Inventory, including questions on dissection experience, spirituality, spiritual perceptions about dissection, and the impact of dissection on spirituality. Descriptive analysis and Chi‐squared tests were used to determine proportions and relationships between variables, with statistical significance at p < 0.05. Most students believe in an afterlife (75.1%), the concept of the soul (92.5%), and the human body as a vessel for the soul (91.3%). About half disagree that human dissection is disrespectful, and faith influences life choices for the majority (95.2%). Human dissection experience lowered students' belief in spirits' interaction with the physical world by 5%, increased their respect for the body (76.2%), and increased their self‐reflection on mortality (84.4%). Despite the lack of profound mystical experiences (82.5%) resulting from the students' dissection experience, there were significant gender differences in the few reported experiences (p = 0.008). Also, there was a significant increase in students' belief in the human spirit following human dissection (p = 0.019). Dissection experience prompts students to reconsider their beliefs and their views of the human body. Despite retaining beliefs in the afterlife and the soul, students' belief in spirits' interaction with the physical world decreases marginally post‐dissection. This study also shows that human dissection is not associated with mystical experiences.
Discrete‐Time Risk Model With Time‐Varying Premiums: Analysis of Ruin Probabilities
Authors: Osatakul Dhiti , Li Shuanming , Wu Xueyuan 
Published: December 2024

ABSTRACTOur paper explores a discrete‐time risk model with time‐varying premiums, investigating two types of correlated claims: main claims and by‐claims. Settlement of the by‐claims can be delayed for up to two time periods, representing real‐world insurance practices. We examine a premium principle based on reported claims, using recursively computable finite‐time ruin probabilities to evaluate the performance of time‐varying premiums. Our findings suggest that, under specific assumptions, a higher probability of by‐claim settlement delays leads to lower ruin probabilities. Moreover, a stronger correlation between main claims and their associated by‐claims results in higher ruin probabilities.