bluuebunny/crossref_metadata_2025_split huggingface dataset:
When the Going Gets Tough: Exploring Changes in the Startup Landscape Due to the Challenges of 2020
Authors: Mahan Tobias , Saravanan Pratima , Krishnakumar Sandeep , Nolte Hannah , McComb Christopher , Menold Jessica 
Published: November 2021

Abstract
Crowdfunding platforms like Kickstarter provide new product developers with a novel and readily accessible platform to interact with potential customers, seek funding, and gain valuable feedback from target users. Successful startup design processes are often praised due to startups’ agility and ability to adapt to changing markets under extreme resource constraints. The COVID-19 pandemic changed the market in a number of significant ways, and publicly available data on Kickstarter provides valuable insight into the fundamental ways that product developers adapt to volatiles markets created by a global crisis. Leveraging linguistic analysis, topic modelling, k-means clustering, and principal component analysis, startup data was analyzed to identify overarching trends in startup launch campaigns across years. Specifically, this work identifies emerging trends in the Kickstarter market in 2020 to understand how external factors affect launch practices. Subtle yet significant changes in Kickstarter campaigns show that new clusters of campaigns emerged during 2020, not present in prior years, indicating that product developers adapted language to meet the needs of a changing market. Findings motivate a more thorough investigation of the relationships between startup market trends and external events to build a deeper understanding of the fundamental ways developers adapt design processes due to external stimuli.
The Human Error and Functional Failure Reasoning Framework: How Does It Scale?
Authors: Irshad Lukman , Demirel H. Onan , Tumer Irem Y. 
Published: November 2021

Abstract
The goal of this research is to demonstrate the applicability of the Human Error and Functional Failure Reasoning (HEFFR) framework to complex engineered systems. Human errors are cited as a root cause of a majority of accidents and performance losses in complex engineered systems. However, a closer look would reveal that such mishaps are often caused by complex interactions between human fallibilities, component vulnerabilities, and poor design. Hence, there is a growing call for risk assessments to analyze human errors and component failures in combination. The HEFFR framework was developed to enable such combined risk assessments. Until now, this framework has only been applied to simple problems, and it is prone to be computationally heavy as complexity increases. In this research, we introduce a modular HEFFR assessment approach as means of managing the complexity and computational costs of the HEFFR simulations of complex engineered systems. Then, we validate the proposed approach by testing the consistency of the HEFFR results between modular and integral assessments and between different module partitioning assessments. Next, we perform a risk assessment of a train locomotive using the modular approach to demonstrate the applicability of the HEFFR framework to complex engineered systems. The results show that the proposed modular approach can produce consistent results while reducing complexity and computational costs. Also, the results from the train locomotive HEFFR analysis show that the modular assessments can be used to produce risk insights similar to integral assessments but with a modular context.
Not Good Enough? Exploring Relationships Between Students’ Empathy, Their Attitudes Towards Sustainability, and the Self-Perceived Sustainability of Their Solutions
Authors: Prabhu Rohan , Alsager Alzayed Mohammed , Starkey Elizabeth 
Published: November 2021

Abstract
Empathy plays an important role in designers’ ability to relate to problems faced by others. Several researchers have studied empathy development in engineering design education; however, a majority of this work has focused on teaching designers to empathize with primary users. Little attention in empathy development research is given to empathizing with those affected in a secondary and tertiary capacity. Moreover, little research has investigated the role of students’ empathy in influencing their emphasis on sustainability, especially in the concept evaluation stage. Our aim in this paper is to explore this research gap through an experimental study with engineering students. Specifically, we introduced first-year engineering students at a large public university in the northeastern United States to a short workshop on sustainable design. We compared changes in their trait empathy and attitudes towards sustainability from before to after participating in the workshop. We also compared the relationship between students’ trait empathy, attitudes towards sustainability, and the self-perceived sustainability of their solutions in a design task. From our results, we see that students reported an increase in their beliefs and intentions towards sustainability and a decrease in their personal distress from before to after participating in the workshop. Furthermore, students’ trait empathy correlated negatively with the self-perceived sustainability of their solutions. These findings highlight the need for future work studying the role of empathy in encouraging a sustainable design mindset among designers.
Sketch-Based Mechanism Simulation Using Machine Learning
Authors: Nurizada Anar , Purwar Anurag 
Published: November 2021

Abstract
This paper presents a machine learning approach for building an object detector for interactive simulation of planar linkages from handmade sketches and drawings found in patents and texts. Touch- and pen-input devices and interfaces have made sketching a more natural way for designers to express their ideas, especially during early design stages, but sketching existing complex mechanisms can be tedious and error-prone. While there are software applications available to help users make drawings, including that of a linkage mechanism, it is both educational and instructive to see existing sketches come to life via automated simulation. However, texts and patents present rich and diverse styles of mechanism drawings, which makes automated recognition difficult. Modern machine learning algorithms for object recognition require an extensive number of training images. However, there are no data sets of planar linkages available online. Therefore, our first goal was to generate images of sketches similar to hand-drawn ones and use state-of-the-art deep generation models, such as β-VAE, to produce more training data from a limited set of images. The latent space of β-VAE was explored by linear and spherical interpolations between sub-spaces and by varying latent space’s dimensions. This served two-fold objectives — 1) examine the possibility of generating new synthesized images via interpolation and 2) develop insights in the dependence of latent space dimension on bar linkage parameters. t-SNE dimensionality reduction technique was implemented to visualize the latent space of a β-VAE in a 2D space. Training images produced by animation rendering were used for fine-tuning a real-time object detection system — YOLOv3.
Coexisting Tetrahedrite–(Zn) and Sphalerite at the Teremki Gold-Ore Deposit (East Transbaikalia): Chemical Composition and Formation Conditions
Authors: Lyubimtseva N. G. , Prokof’ev V. Yu. , Bortnikov N. S. 
Published: November 2021

Abstract
Paragenetic associations of tetrahedrite-(Zn) and sphalerite are distinguished in the Teremki gold-ore deposit. The chemical composition of coexisting minerals of this association is determined. The Sb/(Sb + As) and Fe/(Fe + Zn) ratios in tetrahedrite-(Zn) vary from 0.66 to 0.97 and from 0.28 to 0.40, respectively. A negative correlation was established between Sb/(Sb + As) and Fe/(Fe + Zn) ratios. Contents of Fe in sphalerite change from 0.88 to 1.43 wt % (1.5–2.5 mol % FeS). Temperature and sulfur fugacity when precipitation of tetrahedrite-(Zn)–paragenesis were estimated: they range from 130 to 280°C and from 10–13.2 to 10–8.1 bars, respectively.
Networks of Micellar Chains with Nanoplates
Authors: Molchanov V. S. , Kuklin A. I. , Orekhov A. S. , Arkharova N. A. , Khudoleeva E. S. , Philippova O. E. 
Published: November 2021

Abstract
Nanocomposite networks of surfactant micellar chains and natural bentonite clay nanoplates are studied by rheometry, small-angle neutron scattering, and cryogenic transmission electron microscopy. It is shown that, in an aqueous medium in the presence of a small part of an anionic surfactant, sodium dodecyl sulfate, the molecules of a biodegradable zwitterionic surfactant, oleyl amidopropyl dimethyl carboxybetaine, form micron-length living micellar chains which entangle and form a network possessing well-defined viscoelastic properties. It is found that addition of negatively charged clay nanoplates leads to an increase in viscosity and relaxation time by an order of magnitude. This is explained by the incorporation of the nanoplates into the network as physical multifunctional crosslinks. The incorporation occurs via the attachment of semispherical end-caps of the micelles to the surface of the particles covered with a surfactant layer, as visualized by cryogenic transmission electron microscopy. As the amount of nanoplates is increased, the rheological properties reach plateau; this is associated with the attachment of all end parts of micelles to nanoplates. The developed nanocomposite soft networks based on safe and eco-friendly components are promising for various practical applications.
Vaginal examinations and mistreatment of women during facility-based childbirth in health facilities: secondary analysis of labour observations in Ghana, Guinea and Nigeria
Authors: Adu-Bonsaffoh Kwame , Mehrtash Hedieh , Guure Chris , Maya Ernest , Vogel Joshua P , Irinyenikan Theresa Azonima , Aderoba Adeniyi Kolade , Balde Mamadou Dioulde , Adanu Richard , Bohren Meghan A , Tuncalp Özge 
Published: November 2021

BackgroundPrevious research on mistreatment of women during childbirth has focused on physical and verbal abuse, neglect and stigmatisation. However, other manifestations of mistreatment, such as during vaginal examinations, are relatively underexplored. This study explores four types of mistreatment of women during vaginal examinations: (1) non-consented care, (2) sharing of private information, (3) exposure of genitalia and (4) exposure of breasts.MethodsA secondary analysis of data from the WHO multicountry study ‘How Women Are Treated During Childbirth’ was conducted. The study used direct, continuous labour observations of women giving birth in facilities in Ghana, Guinea and Nigeria. Descriptive and multivariable logistic regression analyses were used to describe the different types of mistreatment of women during vaginal examinations and associated privacy measures (ie, availability of curtains).ResultsOf the 2016 women observed, 1430 (70.9%) underwent any vaginal examination. Across all vaginal examinations, 842/1430 (58.9%) women were observed to receive non-consented care; 233/1430 (16.4%) women had their private information shared; 397/1430 (27.8%) women had their genitalia exposed; and 356/1430 (24.9%) had their breasts exposed. The observed prevalence of mistreatment during vaginal examinations varied across countries. There were country-level differences in the association between absence of privacy measures and mistreatment. Absence of privacy measures was associated with sharing of private information (Ghana: adjusted OR (AOR) 3.8, 95% CI 1.6 to 8.9; Nigeria: AOR 4.9, 95% CI 1.9 to 12.7), genitalia exposure (Ghana: AOR 6.7, 95% CI 2.9 to 14.9; Nigeria: AOR 6.5, 95% CI 2.9 to 14.5), breast exposure (Ghana: AOR 5.9, 95% CI 2.8 to 12.9; Nigeria: AOR 2.7, 95% CI 1.3 to 5.9) and non-consented vaginal examination (Ghana: AOR 2.5, 95% CI 1.4 to 4.7; Guinea: AOR 0.21, 95% CI 0.12 to 0.38).ConclusionOur results highlight the need to ensure better communication and consent processes for vaginal examination during childbirth. In some settings, measures such as availability of curtains were helpful to reduce women’s exposure and sharing of private information, but context-specific interventions will be required to achieve respectful maternity care globally.
Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids
Authors: Meng Qingda , Xie Shanshan , Gray G Kenneth , Dezfulian Mohammad H , Gandarilla Omar , Li Weilin , Huang Ling , Akshinthala Dipikaa , Ferrer Elizabeth , Conahan Catherine , Perea Del Pino Sofia , Grossman Joseph , Elledge Stephen J , Hidalgo Manuel , Muthuswamy Senthil K 
Published: November 2021

BackgroundTumor-specific cytotoxic T cells and T cell receptors are effective tools for cancer immunotherapy. Most efforts to identify them rely on known antigens or lymphocytes that have infiltrated into the tumor bed. Approaches to empirically identify tumor-targeting T cells and T cell receptors by exploiting all antigens expressed on tumor cell surfaces are not well developed for most carcinomas, including pancreatic cancer.MethodsAutologous tumor organoids were stimulated with T cells from the patients’ peripheral blood for 2 weeks to generate the organoid-primed T (opT) cells. opT cell phenotype was analyzed by monitoring changes in the expression levels of 28 cell surface and checkpoint proteins. Expression of ligands of the immune checkpoints was investigated by immunohistochemistry staining. T cells were labeled with carboxyfluorescein succinimidyl ester (CFSE) and assayed by flow cytometry to monitor tumor-induced T cell proliferation changes. opT cell-mediated killing of three-dimensional organoids was measured using an M30 ELISA kit. T cell receptors (TCRs) were identified by deep sequencing of gDNA isolated from T cells, and the TCR specificity was confirmed by transferring TCRs to the T cell line SKW-3 or donor T cells.ResultsThe co-culture was effective in the generation of CD8 + or CD4+opT cells. The opT cells killed autologous tumors in a granzyme B or Fas-Fas ligand-dependent manner and expressed markers of tissue-resident memory phenotype. Each patient-derived opT cell culture displayed a unique complement of checkpoint proteins. Interestingly, only NKG2A blockade showed a potent increase in the interferon-γ production compared with blocking programmed cell death protein 1 (PD-1) or programmed cell death ligand 1 (PD-L1) or TIM3 or TIGIT or LAG3. Importantly, TCR sequencing demonstrated a dramatic clonal expansion of T cells with a restricted subset of TCRs. Cloning and transferring the TCRs to heterologous T cells was sufficient to confer tumor cell recognition and cytotoxic properties in a patient-specific manner.ConclusionWe report a platform for expanding tumor-targeting T cells from the peripheral blood of patients with pancreatic cancer. We identify the NKG2A-HLA-E axis as a potentially important checkpoint for CD8 +T cells for pancreatic cancer. Lastly, we demonstrate empirical identification of tumor-targeting TCRs that can be used for TCR-therapeutics.
Efficacy and safety of vedolizumab and infliximab treatment for immune-mediated diarrhea and colitis in patients with cancer: a two-center observational study
Authors: Zou Fangwen , Faleck David , Thomas Anusha , Harris Jessica , Satish Deepika , Wang Xuemei , Charabaty Aline , Ernstoff Marc S , Glitza Oliva Isabella C , Hanauer Stephen , McQuade Jennifer , Obeid Michel , Shah Amishi , Richards David M , Sharon Elad , Wolchok Jedd , Thompson John , Wang Yinghong 
Published: November 2021

BackgroundCurrent treatment guidelines for immune-mediated diarrhea and colitis (IMDC) recommend steroids as first-line therapy, followed by selective immunosuppressive therapy (SIT) (infliximab or vedolizumab) for refractory cases. We aimed to compare the efficacy of these two SITs and their impact on cancer outcomes.MethodsWe performed a two-center, retrospective observational cohort study of patients with IMDC who received SITs following steroids from 2016 to 2020. Patients’ demographic, clinical, and overall survival data were collected and analyzed.ResultsA total of 184 patients (62 vedolizumab, 94 infliximab, 28 combined sequentially) were included. The efficacy of achieving clinical remission of IMDC was similar (89% vs 88%, p=0.79) between the two groups. Compared with the infliximab group, the vedolizumab group had a shorter steroid exposure (35 vs 50 days, p<0.001), fewer hospitalizations (16% vs 28%, p=0.005), and a shorter hospital stay (median 10.5 vs 13.5 days, p=0.043), but a longer time to clinical response (17.5 vs 13 days, p=0.012). Longer durations of immune checkpoint inhibitors treatment (OR 1.01, p=0.004) and steroid use (OR 1.02, p=0.043), and infliximab use alone (OR 2.51, p=0.039) were associated with higher IMDC recurrence. Furthermore, ≥3 doses of SIT (p=0.011), and fewer steroid tapering attempts (p=0.012) were associated with favorable overall survival.ConclusionsTreatment with vedolizumab as compared with infliximab for IMDC led to comparable IMDC response rates, shorter duration of steroid use, fewer hospitalizations, and lower IMDC recurrence, though with slightly longer time to IMDC response. Higher number of SIT doses was associated with better survival outcome, while more steroid exposure resulted in worse patient outcomes.
Cigarette Smoking and Competing Risks for Fatal and Nonfatal Cardiovascular Disease Subtypes Across the Life Course
Authors: Khan Sadiya S. , Ning Hongyan , Sinha Arjun , Wilkins John , Allen Norrina B. , Vu Thanh Huyen T. , Berry Jarett D. , Lloyd‐Jones Donald M. , Sweis Ranya 
Published: November 2021

Background
Cigarette smoking is significantly associated with premature death related and not related to cardiovascular disease (CVD). Whether risk associated with smoking is similar across CVD subtypes and how this translates into years of life lost is not known.

Methods and Results
We pooled and harmonized individual‐level data from 9 population‐based cohorts in the United States. All participants were free of clinical CVD at baseline with available data on current smoking status, covariates, and CVD outcomes. We examined the association between smoking status and total CVD and CVD subtypes, including fatal and nonfatal coronary heart disease, stroke, congestive heart failure, and other CVD deaths. We performed (1) modified Kaplan–Meier analysis to estimate long‐term risks, (2) adjusted competing Cox models to estimate joint cumulative risks for CVD or noncardiovascular death, and (3) Irwin’s restricted mean to estimate years lived free from and with CVD. Of 106 165 adults, 50.4% were women. Overall long‐term risks for CVD events were 46.0% (95% CI, 44.7–47.3) and 34.7% (95% CI, 33.3–36.0) in middle‐aged men and women, respectively. In middle‐aged men who reported smoking compared with those who did not smoke, competing hazard ratios (HRs) were higher for the first presentation being a fatal CVD event (HR, 1.79 [95% CI, 1.68–1.92]), with a similar pattern among women (HR,1.82 [95% CI, 1.68–1.98]). Smoking was associated with earlier CVD onset by 5.1 and 3.8 years in men and women. Similar patterns were observed in younger and older adults.

Conclusions
Current smoking was associated with a fatal event as the first manifestation of clinical CVD.
Factors Affecting Human-Directed Aggression Resulting in Dog Bites: Contextual Aspects of the Biting Incidents
Authors: Gobbo Elena , Zupan Šemrov Manja 
Published: November 2021

Abstract
Using a web-based questionnaire with 29 close- and open-ended questions about 400 self-reported dog-biting incidents in Slovenia, this research investigated the contexts of dog bites, focusing on characteristics of the dogs and the descriptions of the situations to identify the main risk factors for the occurrence of dog bites. Even though it has been suggested that most dog bites occur during initially non-aggressive interactions with the dog (e.g., during petting, playing), in our study we discerned a wide variety of contexts, including those in which the person did not intend to interact with the dog. Most victims reported unprovoked bites during fast movements near the dog, while coming into close proximity, and during incidents without a reason. These incidents more likely occurred in public than private places and were associated with purebred dogs with a history of aggression.
Vodún/Vodu, Resistance, and North/South Relations in Undemocratic Togo
Authors: Montgomery Eric James 
Published: November 2021

Abstract
Vodún/Vodu have long served as a “way of life” and ontology for making sense of the world along the Bight of Benin, and in the Caribbean and Atlantic world where many slaves were brought. In Togo, the core ethnic groups, the Ewes, continue to turn inward toward Vodún/Vodu traditions as mechanisms of resistance against an autocratic and despotic rule of a northern regime. While the north remains underdeveloped regarding education, economics, and health care delivery—the majority southern Ewes remain locked out of a political process run by the Eyadema regime, who regularly cite north/south conflict as a justification for absolute one-party rule over all of Togo. Vodun/Vodu become motors of modernity through creative assimilation and adaptation to the most pressing geopolitical concerns of the day. This paper assesses the relationship between Vodun/Vodu and contemporary Togolese politics, and its resistance to state-sponsored terror and autocracy.
Homosexuality, Created Bodies, and Queer Fantasies in a Nigerian Deliverance Church
Authors: Richman Naomi 
Published: November 2021

Abstract
In recent years the use of ‘gay cure’ therapies by religions has become a major public controversy in the West. Deliverance, or exorcism, is pointed to as an example of a Christian practice used to try and change a person’s sexuality. Pentecostal churches specialising in deliverance have become particularly popular on the African continent in the last few decades, where beliefs that homosexuality is immoral and un-African are also widespread. At the same time, public discourse about African attitudes to sexuality in the West tends to misunderstand the way religion contributes to cultures of heteronormativity in Africa. This article analyses how African deliverance churches view same-sex relations by investigating a large Nigerian deliverance church publicly accused of practising conversion therapies. It argues that the church’s views on homosexuality derive from its theological understanding of human creation, and that there is more scope for queer expression than first appears.
Is Giriama Traditionalism a Religion? Negotiating Indigenous African Religiosity in ‘Interfaith’ Cooperation in Coastal Kenya
Authors: Meinema Erik 
Published: November 2021

Abstract
This article explores how Giriama elders represent their ‘traditional religion’ (dini ya jadi) through ‘interfaith’ cooperation with Christians and Muslims in the coastal Kenyan town of Malindi. Based on extensive ethnographic research, the article analyses how Giriama Traditionalism relates, in complex and ambivalent ways, to normative assumptions and ideals with regard to what religion entails, and in turn how Giriama elders seek recognition as representatives of a religion in this setting. Such claims are made in a context where Christians, Muslims, and state actors sometimes doubt whether Giriama Traditionalism is worthy of being called a ‘religion’ at all. The article demonstrates that although in the context of interfaith cooperation Christianity, Islam, and ‘Traditionalism’ are formally recognized as equal religions, this does not necessarily create a level playing field. Instead, it requires Giriama elders to appropriate terms, norms, and ideals that are not necessarily of their own making in order for Giriama Traditionalism to be recognized as a religion. Through this analysis, the article aims to contribute to theoretical debates about religious diversity in African contexts by demonstrating how negotiations about what properly counts as (good) religion in coastal Kenya are deeply informed by the copresence of Christianity, Islam, and indigenous African religiosity in one religious field.