bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calpains Induce Egg Production Through Mirnas Secretion in Extracellular Vesicles Released From Paired Adult Worms of Schistosoma Japonicum
Authors: Kumagai Takashi , Shimogawara Rieko , Ichimura Koichiro , Iwanaga Shiroh 
Published: August 2021

Abstract
Extracellular vesicles (EVs) have been reported to be secreted from Schistosoma japonicum at all developmental stages. However, the reproduction and communication mechanisms between the paired adults through the EVs in dioecious Trematoda have not been reported. In this study, EVs containing many exosome-like vesicles and microvesicles were observed in the supernatants of paired adults cultured in vitro, and abundant selected miRNAs were contained in them. In particular, the female-specific miR-bantam was present only in vesicles and was hardly secreted outside the vesicles. In this study, we found that male-female pairing induced secretion of miR-3479 and miR-bantam in EVs, but not of male-specific miR-61. Furthermore, ingestion of mouse erythrocytes also increased the production of miRNAs in paired adult and single female worms. Vesicles were found in the teguments of females treated with erythrocytes under electron microscopy. After the paired worms were treated with several inhibitors against the secretion of EVs, only calpain inhibitor (calpeptin) significantly reduced the amount of miRNA in EVs. Furthermore, the worms treated with only calpeptin inhibited egg production in vitro. Together, these results indicate that qualitative miRNA production through EVs regulated by calpain plays a role in egg production in S. japonicum.
The effect of epilepsy control on psychogenic non epileptic seizures
Authors: Muaz.A.Ibrahim  , Tasneem.M.F  , Ahmed Khabab Abbasher Hussien Mohamed , Abdallah Abdallah M. , Omer Mohammed Eltahier Abdalla , Hussien Abbasher 
Published: August 2021

Abstract
Background: Epilepsy is one of the most common neurological diseases. The coexistence of epilepsy and PNES poses a major challenge to neurologists and psychiatrists in the treatment and follow-up care of patients. Methods: 33 Sudanese patients with epilepsy and concomitant psychogenic non epileptic seizure where included in this study and full detailed history of both epilepsy and PNES was obtained. The study was conducted in Daoud charity clinic during the period from May to July 2018Results : Out of 33 patients 19 were males and 14 were females. Seven patients had focal epilepsy, 23 had generalized tonic clonic epilepsy (GTC), 2 had GTC with atypical absent seizure, and one had GTC with myoclonus.Six patients experienced an attack of PNES after more than 1 year of being free of epilepsy, while 9 patients had PNES attack between 3 months to 1 year of the last attack of epilepsy, and 18 patients developed both PNES and epilepsy within less than 3 months.The pattern of presentation of PNES was bizarre movements in 13 patients, abnormal behavior in 9 patients, while 11 patients experienced both bizarre movement and abnormal behavior note that all those 11 patients had GTC epilepsy. Conclusion: Experiencing psychogenic non epileptic seizure (PNES) in patients with coexisting PNES and epilepsy is not affected by the epilepsy free period
Light And Oxygen Impelling Rubrivivax Gelatinosus Directly Used Food Processing Wastewater To Accumulate Poly-β-Hydroxybutyrate, 5-Aminolevulinic Acid, Pigment
Authors: Wu Pan , Xu Xiaohan 
Published: August 2021

Abstract
Background: Rubrivivax gelatinosus have the advantage of using wastewater to realize biomass recovery. However, they still cannot be large-scale applied because they cannot directly treat the wastewater containing macromolecular organics. Thus, this paper investigated the effect of light-oxygen condition on Rubrivivax gelatinosus (R. gelatinosus) directly recycling wastewater containing macromolecular organics to produce biomass, poly-β-hydroxybutyrate (PHB), 5-Aminolevulinic acid (5-ALA), pigment.Results: R. gelatinosus directly treated the macromolecules organic (soybean protein and starch) wastewaters and achieved biomass recovery under light-anaerobic and light-micro oxygen in six conditions. COD, protein, starch removals for two wastewaters all reached above 70%. Renewable bio-resource such as biomass, PHB, 5-ALA, pigment productions were 10 times of initial content. Theoretical analysis indicated that light activated two component signal pathway by stimulating its first hk gene expression, which regulated synthesis of protease and amylase. However, oxygen concentration decided the level of gene expression and the amount of enzymes. When oxygen was at micro-oxygen or anaerobic, above these expression and synthesis were conducted. Conclusion: In summary, this study expanded the view point ignored by traditional theory. It was realized that PNSB directly treated wastewater and accumulated nutrients (biomass, PHB, pigment and 5-ALA) for recycling, which reduced the secondary pollution of excess sludge to the environment.
Modeling of transient flows in viscoelastic pipe network with partial blockage
Authors: Chahardah-Cherik Parvin , Fathi-Moghadam Manoochehr , Haghighipour Sadegh 
Published: August 2021

Abstract
In this study, transient flow and partial blockage in polyethylene (PE) pipe network are investigated experimentally and numerically using the method of characteristics in the time domain considering pipe-wall viscoelasticity. The experiments were conducted on a PE pipe network with and without partial blockage. The experimental pressure signals were damped during a short period of time in the blockage-free case. The numerical model was calibrated by the inverse transient analysis (ITA). The hydraulic transient solver calibrated with one Kelvin–Voigt element showed good consistency with the experimental results. Partial blockages with different lengths and sizes were examined at different locations of the pipe network. Results reveal an increase in head loss, pressure signal damping, and phase shift with increase in blockage. In addition, the location and characteristics of blockages with different sizes were determined using the ITA in the pipe network.
Translanguaging in an EFL classroom discourse: To what extent it is helpful for the students?
Authors:   Department of English Language Education, Universitas Islam Indonesia, Yogyakarta 55584, Indonesia, Berlianti Dinda Gusti Ayu , Pradita Intan 
Published: August 2021

Translanguaging is a tool for bilingual or multilingual to learn more than one language. In the field of linguistic, translanguaging is not something new. However, its implementation is still found rare in higher education. To fill this void, this study aims to investigate the implementation of translanguaging in classroom, especially in higher education. This research was intended to answer how helpful translanguaging practices in EFL Classroom is. By using qualitative method, the data were collected by recording two credits full face-to-face classroom interaction. One lecturer and her forty-five students voluntarily became the research participants. The data were then analyzed by using thematic analysis. The findings showed that the practices were helpful in a way that the tutors could build an engaging dialogue for the students, enabling them to understand the complex learning materials. These findings then implied that in the teaching and learning process, EFL lecturers tend to be more attentive as they prefer to have their students understanding on complex subject to build English proficiency of their students’.
México frente al reto del conocimiento de frontera del emprendimiento social
Authors: Zerón Félix Mariana , Rubalcava de León Cristian Alejandro , De la Garza Cárdenas Manuel Humberto 
Published: August 2021

Objetivo: analizar el estado del arte de la teoría del emprendimiento social (ES) a nivel internacional para evaluar su nivel de madurez y frontera del conocimiento del periodo 2015-2020, discutiendo la contribución de México a la literatura de las ciencias administrativas, ante la tendencia del es como medio de solución a las problemáticas sociales en el mundo.Diseño metodológico: en la cienciometría se encuentra la técnica de análisis conocida como bibliometría, la cual fue utilizada para realizar dos tipos de análisis: uno desde la perspectiva internacional del emprendimiento social; otro desde la perspectiva en México. Para finalizar se realiza un análisis descriptivo y comparativo.Resultados: en la base de datos bibliográficos de Web of Science se encontró la existencia de 682 artículos publicados sobre el tema de emprendimiento, y en la revisión bibliográfica exhaustiva de las revistas del Sistema de Clasificación de Revistas Mexicanas de Ciencia y Tecnología (CRMCYT), en el área de ciencias sociales y multidisciplinarias, la existencia de 81 artículos relacionados. Limitaciones de la investigación: la principal limitación es que en el CRMCYT la mayoría de las revistas no generan los reportes en los formatos requeridos por el software especializado para bibliometría (Bibliometrix). Hallazgos: el interés del ES en las áreas de gestión y emprendimiento es muy reciente, así que el presente análisis abre discusión sobre la necesidad de crear puentes conceptuales que denoten la realidad en México sobre el tema del ES.
Anti - Inflammatory Activity of Quercetin and Kaempferol Is Limited to Tlr4 Stimulation in Monocytes
Authors: Pothuganti Manoj Kumar  , Madhuri Padala  , Sudharshan Reddy Nelli  , Surya Satyanarayana Singh  
Published: August 2021

Flavonoids are known to exert anti-inflammatory activity but their mechanism at receptor level and their comparative potencies are less studied. Objective of the study is to evaluate, rank order few flavonoids for their cytokine inhibitory activity in monocytes (THP-1) and explore the inhibitory signature among toll-like receptors (TLRs). We tested flavonoids for their potential to inhibit LPS induced cytokines IL-6, TNF alpha in human monocyte cell line THP-1 and mouse macrophage cell line using Enzyme linked immunosorbent assay (ELISA) assays. Quercetin and Kaempferol reduced LPS induced cytokine secretion in monocyte and macrophage cell lines. Quercetin and Kaempferol demonstrated dose dependent inhibition of cytokines IL-6 and TNF alpha. Quercetin demonstrated IC50 of 6.9µM whereas Kaempferol demonstrated IC50 of 14.3µM in cytokine reduction. In THP-1, NF-kB activity is measured using secreted embryonic alkaline phosphatase (SEAP) reporter with different toll-like receptor activation. TLR4 stimulated NF-kB activity was inhibited by Quercetin and Kaempferol in THP-1 cell line, while these flavonoids did not impact signaling of other TLR ligands Pam3CSK4 (TLR1/2) FLS (TLR2/6), Flagellin (TLR5) and R848 (TLR7/8). I. Quercetin and Kaempferol modulate NF-kB activity when stimulated with TLR4, but not with TLR1/2, TLR2/6, TLR5 and TLR7/8 in Monocytes. Understanding the inhibition profile of flavonoids against Toll receptors will help in design better inhibitor which can alleviate inflammatory diseases
PENGARUH KEPERCAYAAN MEREK, PERIKLANAN, DAN KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN PRODUK MINUMAN ISOTONIK MIZONE DI KOTA PALU
Authors: Fauzan Muh Rizky , Sutomo Maskuri , Mubaraq Rahmat 
Published: August 2021

The aim of the research is to analyze the influence of brand trust (X1), advertising (X2), and product quality (X3) on purchase decision (Y) both simultaneously and partially. Research method is descriptive causal with a sample size of 115 respondents who are selected using purposive sampling technique. The results of the study show that: 1) brand trust, advertising, and product quality simultaneously have positive and significant influence on purchase decision of customer of Mizone isotonic drink in Palu; 2) brand trust has positive and significant influence on purchase decision of customer of Mizone isotonic drink in Palu; 3) advertising has positive and significant influence on purchase decision of customer of Mizone isotonic drink in Palu; 4) product quality has positive and significant influence on purchase decision of customer of Mizone isotonic drink in Palu. Tujuan penelitian ini adalah untuk menganalisis pengaruh Kepercayaan Merek (X1), Periklanan (X2), dan Kualitas Produk (X3) terhadap Keputusan Pembelian (Y). Metode penelitian yang digunakan adalah metode deskriptif kausal dengan jumlah sampel 115 orang dengan teknik purposive sampling. Hasil penelitian menunjukkan bahwa: 1). Variabel kepercayaan merek, variable periklanan, dan variable kualitas produk secara simultan berpengaruh positif dan signifikan terhadap variable keputusan pembelian produk minuman Isotonik Mizone pada masyarakat di Kota Palu; 2). Variabel kepercayaan merek secara parsial berpengaruh positif dan signifikan terhadap variable keputusan pembelian produk minuman Isotonik Mizone pada masyarakat di Kota Palu; 3). Variabel periklanan secara parsial berpengaruh positif dan signifikan terhadap variabel keputusan pembelian produk minuman Isotonik pada masyarakat di Kota Palu; dan 4). Variabel kualitas produk secara parsial berpengaruh positif dan signifikan terhadap variabel keputusan pembelian produk minuman Isotonik pada masyarakat di Kota Palu
STRATEGI BERSAING PADA GELATIK RESIDENCE PALU
Authors: Djuma Tanwir D G , Tanamal Johnny , Parani Syamsul Bachri Daeng 
Published: August 2021

PT. Regional Trypillian is a company that is engaged in the development of new houses to prosper the society, especially by providing residence and develop its role in economic development in marketing the residential products and utilization of manpower. The establishment of the company initiated by Mr. Sofyan Hudri since February 15, 2014, starting from an attempt to manage, market, and produce home with investors/landowners. Wren's housing residence consists of 2 types: type 50 and type 90. The purpose of this study is to determine competition faced by Wren Residence in Palu and to examine alternative strategies that can be used by Wren Residence. Data analysis technique used is the SWOT analysis (Strength, Weakness, Opportunity, Threat). Based on the results of SWOT analysis in the form of matrix diagram and IE table, it finds that competitive strategies of Wren Residence is focused on aggressive strategy (growth-oriented strategy) that is suitable with the existing opportunities. PT. Regional Trypillian adalah perusahaan yang bergerak dalam pengembangan rumah baru untuk mencapai kesejahteraan masyarakat, terutama dengan menyediakan tempat tinggal dan mengembangkan perannya dalam pembangunan ekonomi dalam memasarkan produk hunian dan pemanfaatan tenaga kerja. Pembentukan perusahaan yang diprakarsai oleh Bapak Sofyan Hudri sejak 15 Februari 2014 ini, mulai dari usaha mengelola, memasarkan, dan menghasilkan rumah dengan investor / pemilik lahan. Tempat tinggal Wren terdiri dari 2 tipe: tipe 50 dan tipe 90. Tujuan dari penelitian ini adalah untuk mengetahui kompetisi yang dihadapi Wren Residence di Palu dan untuk mengkaji strategi alternatif yang dapat digunakan oleh Wren Residence. Teknik analisis data yang digunakan adalah analisis SWOT (Strength, Weakness, Opportunity, Threat). Berdasarkan hasil analisis SWOT berupa diagram matriks dan tabel IE, maka strategi kompetitif Wren Residence difokuskan pada strategi agresif (strategi berorientasi pertumbuhan) yang sesuai dengan peluang yang ada.
FAKTOR-FAKTOR YANG DIPERTIMBANGKAN KONSUMEN MEMUTUSKAN MEMBELI DAN MENGGUNAKAN SMARTPHONE MEREK OPPO DI KECAMATAN PALU SELATAN
Authors: Ndari Tria Wulan , Wahyuningsih Wahyuningsih , Kornelius Yobert 
Published: August 2021

This study aims to determine factors that consumers consider in buying and using smartphones OPPO in South Palu Sub-district. The sampling technique is Accidental Side by selecting 105 people. The analytical tool is factor analysis. Based on the analysis of 21 indicators, the study finds factors that are considered by the consumers when deciding to buy and use a smartphone brand OPPO are:the first factors includes: promotion and price: X3 (Advertising media TV), X12 (promotions convincing), X14 (Prices are affordable), X15 (the physical form of interest), X17 (service center/customer service); the second factor is product quality that includes: X2 (friends suggestion), X6 (sophisticated feature), X10 (superior camera quality), X11 (good product quality), X21 (correspondence between price and quality); the third factor is lifestyle that includes: X1 (family suggestion), X16 (luxury product design), X19 (unique name and easy to remember), X20 (updated trend). Penelitian ini bertujuan untuk mengetahui faktor-faktor yang dipertimbangkan konsumen dalam membeli dan menggunakan smartphone OPPO di Kecamatan Palu Selatan. Teknik pengambilan sampel adalah Accidental Side dengan memilih 105 orang. Alat analisis adalah analisis faktor. Berdasarkan analisis 21 indikator tersebut, studi ini menemukan faktor-faktor yang dipertimbangkan konsumen saat memutuskan untuk membeli dan menggunakan merek smartphone OPPO adalah:faktor pertama meliputi: promosi dan harga: X3 (media iklan TV), X12 (promosi yang meyakinkan ), X14 (Harga terjangkau), X15 (bentuk fisik bunga), X17 (service center / customer service); Faktor kedua adalah kualitas produk yang meliputi: X2 (saran teman), X6 (fitur canggih), X10 (kualitas kamera superior), X11 (kualitas produk yang baik), X21 (korespondensi antara harga dan kualitas);Faktor ketiga adalah gaya hidup yang meliputi: X1 (family suggestion), X16 (desain produk mewah), X19 (nama unik dan mudah diingat), X20 (mengikuti trend masa kini).
STRATEGI BERSAING RUMAH MAKAN HENI PUTRI KAILI
Authors: Wengkau Raymondo , Chalil Chalil , Maskuri Maskuri 
Published: August 2021

Heni Putri Kaili Restaurant is located at Kaombona Street/ Kampung Nelayan No. 09 Talise, East Palu Sub-district, Palu City. Heni Putri Kaili restaurant has been established since 6 years ago, precisely on February 20th 2010. The owner of the restaurant is Mrs. Haeni R. Kara , S.Pd. The research intends to find out the competitive level faced by Heni Putri Kaili Restaurant among the restaurant industries in Palu City and to comprehend the alternative strategy that can be used by Heni Putri Kaili Restaurant. Data analysis methods used are Porter’s Five Forces analysis and the SWOT (Strength, Weakness, Opportunities, Threats) analysis. Based on Porter’s Five Forces analysis, the study concludes that Heni Putri Kaili restaurant experiences a great rivalry among the restaurant industries in Palu City, which includes the rivalry beetween the competitors from the similiar industry, the suplier’s supplying capacity, and the threat of substitutes products. The result of SWOT metric diagram and IE table suggests that Heni Putri Kaili Restaurant should focus on the diversifications strategy while improving the service and the strategy to increase the promotion of the main product together with other products that are still unfamiliar by the consumers/markets. Heni Putri Kaili Restaurant terletak di Kampung Nelayan No. 09 Talise, Kecamatan Palu Timur, Kota Palu. Restoran Heni Putri Kaili telah berdiri sejak 6 tahun yang lalu, tepatnya pada 20 Februari 2010. Pemilik restoran tersebut adalah Nyonya Haeni R. Kara, S.Pd. Tujuan penelitian ini adalah untuk mengetahui kondisi persaingan restoran Heni Putri Kaili di antara industri restoran di Kota Palu dan untuk mengetahui strategi alternatif yang dapat digunakan oleh restoran Heni Putri Kaili. Metode analisis data yang digunakan adalah analisis Lima Kekuatan Porter dan SWOT (Strength, Weakness, Opportunities, Threats). Berdasarkan analisis Lima Kekuatan Porter, dapat disimpulkan bahwa persaingan antara restoran Heni Putri Kaili di industri restoran di Kota Palu mengalami persaingan yang sangat baik. Ada banyak faktor; persaingan antara pesaing dari industri serupa, kapasitas penyuplai suplier, dan ancaman produk substitusi. Sebagai hasil diagram metrik SWOT dan tabel IE, strategi kompetitif dapat direkomendasikan. Restoran Heni Putri Kaili berfokus pada Strategi Diversifikasi dengan program strategi untuk menegakkan dan memperbaiki layanan dan strategi untuk meningkatkan promosi produk unggulan tanpa meninggalkan produk lain yang masih belum diketahui oleh konsumen / pasar.
PENGARUH BAURAN PROMOSI TERHADAP KEPUTUSAN NASABAH DALAM MENGGUNAKAN TABUNGAN iB HASANAH PADA PT. BNI SYARIAH CABANG PALU
Authors: Faisal Imam Agus , Chalil Chalil , Nirwan Nirwan 
Published: August 2021

The research aims to find out the influence of mix promotion on customer decision in using iB Hasanah saving at PT. BNI Syariah Branch Palu. The variable used are advertisement (X1), selling promotion (X2), relationship between people (X3), personal selling (X4), direct marketing (X5), as well as variable customer decision (Y). This is a quantitative research. Sample consists of 72 respondents who are the customers of iB Hasanah saving at PT. BNI Syariah Branch Palu. Method of analysis is multiple linear regressions. The research results indicate that variable of mix promotion simultaneously affect on customer decision. Advertisement partially affect on customer decision, while selling promotion, people relationship, personal selling, and direct marketing partially have non-significant influence on customer decision. Penelitian ini bertujuan untuk mengetahui pengaruh bauran promosi terhadap keputusan pelanggan dalam menggunakan tabungan iB Hasanah pada PT. BNI Syariah Cabang Palu, variabel yang digunakan adalah variabel iklan (X1), variabel promosi penjualan (X2), variabel hubungan masyarakat (X3), variabel penjualan personal (X4), pemasaran langsung (X5), serta variabel keputusan pelanggan (Y). Ini adalah penelitian kuantitatif. Sampel yang digunakan adalah 72 responden yang pelanggannya menggunakan tabungan iB Hasanah di PT. BNI Syariah Cabang Palu. Metode yang digunakan adalah analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa variabel bauran promosi secara simultan berpengaruh terhadap keputusan pelanggan. Iklan secara parsial mempengaruhi keputusan pelanggan, promosi penjualan berpengaruh tidak signifikan terhadap keputusan pelanggan, hubungan masyarakat berpengaruh tidak signifikan terhadap keputusan pelanggan, penjualan pribadi berpengaruh tidak signifikan terhadap keputusan pelanggan, pemasaran langsung berpengaruh tidak signifikan terhadap keputusan pelanggan.