bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generation and properties of the new asphalt binder model using molecular dynamics (MD)
Authors: Yao Hui , Liu Junfu , Xu Mei , Bick Andreas , Xu Qing , Zhang Jinxi 
Published: May 2021

AbstractAsphalt binder is the main material for road pavement and building construction. It is a complex mixture composed of a large number of hydrocarbons with different molecular weights. The study of asphalt binders and asphalt concretes from a molecular perspective is an important means to understand the intricate properties of asphalt. Molecular dynamics simulation is based on Newton’s law and predicts the microscopic performance of materials by calculating the intra- and intermolecular interactions. The asphalt binder can be divided into four components: saturates, aromatics, resins, and asphaltenes (SARA). A new molecular model of asphalt was proposed and verified in this study. Eight molecules selected from the literature were used to represent the four components of asphalt. The AMBER Cornell Extension Force Field was applied in this study to model building and the calculation of properties. The density of the asphalt model was calculated and compared with experimental results for validity verifications. The results show that the purposed model can be used to calculate the microscopic properties of the asphalt binder because the density of the model is close to the real value in the field. Besides, the proportions of different molecules in the model were adjusted to predict the relationship between the asphalt binder density and the hydrocarbon ratios and heteroatom contents of the molecular model. Moreover, the glass transition temperature of the asphalt binder model is predicted by the simulation of the heating process. The range of the glass transition temperature is determined by calculating the relationship between specific volume and temperature, and the calculated range is close to the experimental value.
Ultrasonication-mediated nitrogen-doped multiwalled carbon nanotubes involving carboxy methylcellulose composite for solid-state supercapacitor applications
Authors: Basivi Praveen Kumar , Ramesh Sivalingam , Kakani Vijay , Yadav H. M. , Bathula Chinna , Afsar N. , Sivasamy Arumugam , Kim Heung Soo , Pasupuleti Visweswara Rao , Lee Handol 
Published: May 2021

AbstractIn this study, a novel nanohybrid composite containing nitrogen-doped multiwalled carbon nanotubes/carboxymethylcellulose (N-MWCNT/CMC) was synthesized for supercapacitor applications. The synthesized composite materials were subjected to an ultrasonication-mediated solvothermal hydrothermal reaction. The synthesized nanohybrid composite electrode material was characterized using analytical methods to confirm its structure and morphology. The electrochemical properties of the composite electrode were investigated using cyclic voltammetry (CV), galvanic charge–discharge, and electrochemical impedance spectroscopy (EIS) using a 3 M KOH electrolyte. The fabricated composite material exhibited unique electrochemical properties by delivering a maximum specific capacitance of approximately 274 F g−1 at a current density of 2 A g−1. The composite electrode displayed high cycling stability of 96% after 4000 cycles at 2 A g−1, indicating that it is favorable for supercapacitor applications.
Enhanced electrical conductivity and mechanical properties in thermally stable fine-grained copper wire
Authors: Mao Qingzhong , Zhang Yusheng , Guo Yazhou , Zhao Yonghao 
Published: May 2021

AbstractThe rapid development of high-speed rail requires copper contact wire that simultaneously possesses excellent electrical conductivity, thermal stability and mechanical properties. Unfortunately, these are generally mutually exclusive properties. Here, we demonstrate directional optimization of microstructure and overcome the strength-conductivity tradeoff in copper wire. We use rotary swaging to prepare copper wire with a fiber texture and long ultrafine grains aligned along the wire axis. The wire exhibits a high electrical conductivity of 97% of the international annealed copper standard (IACS), a yield strength of over 450 MPa, high impact and wear resistances, and thermal stability of up to 573 K for 1 h. Subsequent annealing enhances the conductivity to 103 % of IACS while maintaining a yield strength above 380 MPa. The long grains provide a channel for free electrons, while the low-angle grain boundaries between ultrafine grains block dislocation slip and crack propagation, and lower the ability for boundary migration.
Decentralizing indexing and bootstrapping for online applications
Authors: Schutz Pierre , Gal Stanislas , Chatzopoulos Dimitris , Hui Pan 
Published: May 2021

AbstractPeer‐to‐peer (P2P) networks utilize centralized entities (trackers) to assist peers in finding and exchanging information. Although modern P2P protocols are now trackerless and their function relies on distributed hash tables (DHTs), centralized entities are still needed to build file indices (indexing) and assist users in joining DHT swarms (bootstrapping). Although the functionality of these centralized entities are limited, every peer in the network is expected to trust them to function as expected (e.g. to correctly index new files). In this work, a new approach for designing and building decentralized online applications is proposed by introducing DIBDApp. The approach combines blockchain, smart contracts and BitTorrent for building up a combined technology that permits to create decentralized applications that do not require any assistance from centralized entities. DIBDApp is a software library composed of Ethereum smart contracts and an API to the BitTorrent protocol that fully decentralizes indexing, bootstrapping and file storing. DIBDApp enables any peer to seamlessly connect to the designed smart contracts via the Web3J protocol. Extensive experimentation on the Rinkeby Ethereum testnet shows that applications built using the DIBDApp library can perform the same operations as in traditional back‐end architectures with a gas cost of a few USD cents.
Application of blockchain in the cluster of unmanned aerial vehicles
Authors: Chen Shiwu , Li Qin , Wang Wei , Yang Yu , Jiang Jun 
Published: May 2021

AbstractWith the considerable exploration of unmanned aerial vehicles in civilian and military fields, the data storage and transmission mechanism of unmanned aerial vehicles exhibit significant security limitations, which cannot meet the strict requirements for data security in civilian and military business scenarios. In recent years, blockchain technology has been tried to be applied to multiple fields. The features of blockchain includes decentralization, immutability, transparency and auditability, make transactions more secure and tamper proof. In view of the many excellent features of blockchain, in this paper, blockchain technology is introduced into the application of cluster of unmanned aerial vehicles, aiming to solve the problems of identity authentication, secure and reliable transmission of data between unmanned aerial vehicles, and access control of the data on the blockchain, thereby to enhance the security of the cluster of unmanned aerial vehicles and to ensure the integrity and security of data.
Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants in Pediatric Venous Thromboembolism Treatment and Thromboprophylaxis: A Systematic Review of the Literature
Authors: Branstetter Joshua W. , Kiskaddon Amy L. , King Madeleine A. , Coalter Carli , Grubbs Kimberly M. , Fly Hunter , Male Christoph , Brandão Leonardo , Goldenberg Neil A. 
Published: May 2021

AbstractVenous thromboembolism (VTE) in children can lead to significant morbidity and mortality. Traditionally, treatment for thrombotic events in pediatric patients has been limited mainly to unfractionated heparin, low-molecular-weight heparin (LMWH), or vitamin K antagonists. Since the first non–vitamin K antagonist oral anticoagulant (NOAC) was approved for adult use, these agents have gained popularity for a variety of indications. This is largely due to their ease of administration, favorable pharmacokinetic and pharmacodynamic profile, decreased food interactions, and decreased need for therapeutic drug monitoring. Treating and preventing VTE with traditional anticoagulants in pediatric patients presents many challenges. This systematic review evaluated the current literature regarding pediatric NOAC trials. Additionally, based on an up-to-date query of clinicaltrials.gov, we detail current ongoing and as-yet unpublished clinical trials, study outcomes, and projected completion dates. Published pediatric NOAC trials have included 1,007 total children to date and have ranged from phase 1 to 4, with “indications” including both thromboembolism prophylaxis and VTE treatment. Three recent phase 3 trials, specifically involving rivaroxaban and dabigatran, have shown the agents to be at least as effective as traditional anticoagulants for acute and/or extended VTE treatment, with low frequency of recurrent thrombosis and clinically significant bleeding rates. Additionally, specially developed and tested pediatric formulations have allowed for accurate and reliable dosing, oral administration, stable pharmacokinetics and pharmacodynamics, and fewer drug or food interactions. Ongoing trials, anticipated for completion in the next few years, will reveal important information with regard to thromboembolism prophylaxis in special pediatric subpopulations and settings.
The Advent of Spinoplastics: Easing the Growing Global Disease Burden of Spinal Injury
Authors: Delancy Matthew M. , Perdanasari Aurelia , Davis Matthew J. , Abu-Ghname Amjed , Kaplan Jordan , Winocour Sebastian J. , Reece Edward M. , Sim Alfred Sutrisno 
Published: May 2021

AbstractEpidemiologic studies have demonstrated a growing global disease burden of pathologies affecting the vertebral column. Allograft or implant-based reconstruction and fusion surgeries have been the mainstay of treatment. The efficacy of various surgical methods and the reliability of instrumentation or implants to execute these surgeries continue to be debated in the literature. Advances such as the free-tissue transfer have improved postoperative measures; however, they add high operative risk. The advent of spinoplastics introduces a practical surgical model to augment these spinal surgeries using vascularized bone grafts. As this technique becomes more widespread, it can be utilized to ease the growing disease burden that spinal injury places on both patients and the health care system. Ultimately, it will ameliorate strains on health care resources, reduce health care costs, and improve patient outcomes and quality of life.
Vascularized Bone Grafts in Spinal Reconstruction: An Overview of Nomenclature and Indications
Authors: Skochdopole Anna J. , Wagner Ryan D. , Davis Matthew J. , Raj Sarth , Winocour Sebastian J. , Ropper Alexander E. , Xu David S. , Bohl Michael A. , Reece Edward M. 
Published: May 2021

AbstractSeveral vascularized bone grafts (VBGs) have been introduced for reconstruction and augmenting fusion of the spine. The expanding use of VBGs in the field of spinoplastic reconstruction, however, has highlighted the need to clarify the nomenclature for bony reconstruction as well as establish the position of VBGs on the bony reconstructive algorithm. In the current literature, the terms “flap” and “graft” are often applied inconsistently when describing vascularized bone transfer. Such inconsistency creates barriers in communication between physicians, confusion in interpreting the existing studies, and difficulty in comparing surgical techniques. VBGs are defined as bone segments transferred on their corresponding muscular attachments without a named major feeding vessel. The bone is directly vascularized by the muscle attachments and unnamed periosteal feeding vessels. VBGs are best positioned as a separate entity in the bony reconstruction algorithm between nonvascularized bone grafts (N-VBGs) and bone flaps. VBGs offer numerous advantages as they supply fully vascularized bone to the recipient site without the microsurgical techniques or pedicle dissection required for raising bone flaps. Multiple VBGs have been introduced in recent years to optimize these benefits for spinoplastic reconstruction.
Extending the in vivo Half-Life of Adalimumab Fab via Sortase A-Mediated Conjugation of Adalimumab Fab with Modified Fatty Acids
Authors: Zhang Qing-Bin , Ruan Si-Da , Wu Yong , Zhang Jin-Hua , Lu Jian-Guang , Feng Jun 
Published: May 2021

AbstractAdalimumab, a full-length monoclonal antibody, is widely used as an anti-tumor necrosis factor-α (anti-TNF-α) agent. In this article, we aimed to prolong the in vivo half-life of adalimumab antigen-binding fragment (Fab) through Sortase A (SrtA)-mediated conjugation of its Fab with fatty acid (FA). In our study, adalimumab Fab analog was prepared by adding an SrtA recognition sequence (LPETGG) and His6 tag to the heavy chain C-terminal of the Fab via (G4S)3 linker. Four FA motifs with different linkers were designed and synthesized by solid-phase methodology, then conjugated with the Fab analog using SrtA to produce Fab bioconjugates. The successful generation of four Fab bioconjugates (Fab–FA1, Fab–FA2, Fab–FA3, and Fab–FA4) was confirmed by SDS-PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis) and mass spectrometry. Then, the bioactivities and half-life of these Fab bioconjugates were examined using TNF-α-/human serum albumin (HSA)-binding enzyme-linked immunosorbent assay, cytotoxicity assay, and pharmacokinetic study, respectively. All Fab bioconjugates exhibited similar TNF-α-neutralizing activities when compared with the Fab analog, even in the presence of albumin, indicating that there were no apparent influences on the functional site of Fab after FA modification. However, different degrees of affinity for HSA were observed among these Fab–FA bioconjugates, with Fab–FA3 exhibiting the maximal affinity. An in vivo study in mice further revealed remarkably improved pharmacokinetics of Fab– FA3 with a 15.2-fold longer plasma half-life (19.86 hours) compared with that of the Fab analog (1.31 hours). In summary, we have developed a novel long-acting adalimumab Fab bioconjugate, Fab–FA3, with more sustained in vivo activity, which can be used for drug development targeting TNF-α-mediated inflammatory diseases.
Parent Perception of Child Safety following Admission to a Neonatal Unit
Authors: Arriaga-Redondo María , Sanz-Lopez Ester , Rodríguez-Sánchez de la Blanca Ana , Marsinyach-Ros Itziar , Lambea-Rueda Leticia , Díaz-Redondo Alicia , Sanchez-Luna Manuel 
Published: May 2021

Objective Parent partnership is a key aspect of neonatal hospital care. However, there is a lack of information regarding parents' perception of neonatal safety. This study explores parents' opinions on safety during their child's hospitalization to identify points for improvement.
Study Design We used a questionnaire, validated by the Spanish National Healthcare Authorities, on perception of safety with respect to hospital health care.
Results Thirty-seven parents of 20 newborns treated in the neonatal intensive care unit (NICU) and 139 parents of newborns in intermediate care (IC) participated in this study. With regard to overall perception of safety, more than 96% of parents felt “very safe” or “fairly safe.” In the NICU, an area for improvement detected was to ask parents more often their opinion about the care or treatment provided to their child. In IC, three points for improvement were identified from the group of parents whose child was admitted directly to IC: the consistency of the information received, the request for consent for procedures, and the request for an opinion on their child's care and treatment. Only four parents reported that their child suffered an incident. Regarding incident management, parents were not completely satisfied with the information they received.
Conclusion To the best of our knowledge, this is the first study of parent perception of patient safety in a neonatal unit using a validated questionnaire. Our findings suggest that parents can provide valuable information on neonatal safety, which can then be used to identify areas for improvement.
Key Points
Direct End-to-End Neurorrhaphy for Wrist-Level Long Nerve Defect with Fixation of the Wrist in Flexion: Technique Note
Authors: Lu Chun-Ching , Huang Hui-Kuang , Wang Jung-Pan 
Published: May 2021

Abstract
Background For a nerve gap, end-to-end neurorrhaphy would either be difficult or would include tension. The use of a nerve graft or conduit could be a solution, but it might compromise the reinnervation. We describe a method for wrist-level ulnar and/or median long nerve injury by fixing the wrist in the flexion position with K-wire (s) to make possible an end-to-end and tension-free neurorrhaphy.
Patients and Methods Two patients had wrist-level ulnar nerve injury for 2 and 3 months and nerve gaps of 2.5 cm and 3.5 cm, respectively, after the neuroma excision. K-wires were used to transfix from the radius to carpal bones, in order to keep their wrists in flexion of 45 and 65 degrees, respectively, with which the tension-free end-to-end neurorrhaphy could be achieved. The K-wires were removed in 6 weeks after surgery, and their wrists were kept in the splint for a progressive extension program.
Results Both patients were noted to have an improved claw hand deformity 4 months after the surgery. The ulnar nerve motor and sensory function could be recovered mostly in the 12-month follow-up. The wrist flexion and extension motion arc both achieved, at least, 150 degree in the 12-month follow-up. There were no complications related to the K-wire fixation.
Conclusion With the wrist fixed in a flexed position, maintaining a longer nerve gap to achieve a direct end-to-end and tension-free neurorrhaphy would be more likely and safer. Without the use of nerve graft, innervation of the injured nerve would be faster.
Carceral-community epidemiology, structural racism, and COVID-19 disparities
Authors: Reinhart Eric , Chen Daniel L. 
Published: May 2021

Significance
As jails and prisons remain leading sites of COVID-19 outbreaks, mass incarceration poses ongoing health risks for communities. We investigate whether short-term jailing of individuals prior to release may drive COVID-19 spread. We find that cycling individuals through Cook County Jail in March 2020 alone can account for 13% of all COVID-19 cases and 21% of racial COVID-19 disparities in Chicago as of early August. We conclude that detention for alleged offenses that can be safely managed without incarceration is likely harming public safety and driving racial health disparities. These findings reinforce consensus among public health experts that large-scale decarceration should be implemented to protect incarcerated people, mitigate disease spread and racial disparities, and improve biosecurity and pandemic preparedness.
2′-O methylation of RNA cap in SARS-CoV-2 captured by serial crystallography
Authors: Wilamowski Mateusz , Sherrell Darren A. , Minasov George , Kim Youngchang , Shuvalova Ludmilla , Lavens Alex , Chard Ryan , Maltseva Natalia , Jedrzejczak Robert , Rosas-Lemus Monica , Saint Nickolaus , Foster Ian T. , Michalska Karolina , Satchell Karla J. F. , Joachimiak Andrzej 
Published: May 2021

Significance
The 2′-O methyl group in Cap-1 is essential to protect viral RNA from host interferon-induced response. We determined crystal structures of SARS-CoV-2 Nsp10/16 heterodimer in complex with substrates (Cap-0 analog and S-adenosyl methionine) and products (Cap-1 analog and S-adenosyl-L-homocysteine) at room temperature using synchrotron serial crystallography. Analysis of these structures will aid structure-based drug design against 2′-O-methyltransferase from SARS-CoV-2.
An eye-tracking study examining information search in transit maps
Authors: Wang Zheng , Lonsdale Maria dos Santos , Cheung Vien 
Published: May 2021

Abstract
This study investigates the legibility of China’s high-speed railway map through eye-tracking measurement. The information searching process was identified by conducting: (1) Scoping stage – a user performance test and interview to inform the design of the eye-tracking study; (2) In-depth stage – an eye-tracking study. A number of visual design problems with the map have been identified. This research explores user-centered design map solutions and provides detailed design guidance for transit maps. It also demonstrates that eye-tracking is an effective method of evaluating the design quality of a transit map as it can identify design limitations and user needs.
MSIGEN: Multi-Scale Illumination-Guided Low-Light Image Enhancement Network
Authors: Hao Yue , Jiang Xuemei , Hu Jiwei , Lou Ping 
Published: May 2021

Abstract
Images lack of light often show the characteristics of low visibility, low contrast and high noise, due to limited imaging equipment. To address the problem, inspired by Retinex theory, we propose a two-stage method called Multi-Scale Illumination-Guided Low-Light Image Enhancement Network (denoted as MSIGEN). In the first stage, we employ an enhancement module to achieve low-light image enhancement, including a Decom-Net for decomposing into illumination and reflectance, an Adjust-Net for illumination adjustment, a Restore-Net for the illumination fusion map guided reflectance restoration. Secondly, the enhancement module is introduced to refine the initial images to effectively remove visual defects amplified and ensure the naturalness of the image. In addition, extensive experiment results demonstrate the advantages of our method and the effect of this method has reached the state-of-the-art.
Detection of water seepage in lake body using ground penetrating radar method
Authors: Yulianita Dina , Aisyah Rizha Rizky , Wafi Abdurrahman , Setiawan Nugroho Syarif , Mariyanto Mariyanto 
Published: May 2021

Abstract
Ground Penetrating Radar (GPR) is a geophysical method used to identification subsurface condition at a certain depth, using a source of electromagnetic waves in the form of radar. Geoscanners Akula A9000C and Antenna Gecko 60 with 60 MHz antenna frequency were used for data acquisition for this study. Survey data was conducted as many four lines, located on the south and east sides of the lake, with the distance range from 0 to 145 m. This paper reports basic signal processing GPR data using matGPR for the analysis and modelling. The results show that there is anomaly which is suspected as water seepage appear on depth of 2 m. On the lengthwise line, anomalies show on a distance of 20 m and 35 m (line A) and 125 m and 135 m (line B), while on the crosswise line anomalies show on a distance of 35 m and 50 m (line C), 25 m and 95 m (line D). Water seepage can be found in this area as it is formed by alluvial depositional environment, remembering that the characteristics and rocks lithology in this area can stimulate water infiltration process. Water seepage will cause erosion of the lake and can collapse the lake’s structure.