bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naphthalimide‐Based Dyes as Photoinitiators under Visible Light Irradiation and their Applications: Photocomposite Synthesis, 3D printing and Polymerization in Water
Authors: Rahal Mahmoud , Mokbel Haifaa , Graff Bernadette , Pertici Vincent , Gigmes Didier , Toufaily Joumana , Hamieh Tayssir , Dumur Frédéric , Lalevée Jacques 
Published: January 2021

AbstractIn this work, six new fluorescent dyes derived from the naphthalimide scaffold (Napht1–Napht6) were synthesized and used as high‐performance photoinitiating systems (PISs) in two and three‐component systems (combined with iodonium salt (Iod) and/or an electron donor amine (such as N‐phenylglycine[NPG])) for the radical photopolymerization of acrylate and methacrylate monomers under visible light using a light‐emitting diode at 405 nm. Markedly, these dyes were never synthesized before. In fact, these PISs showed high initiation efficiency with both demonstrating high final reactive function conversions and high polymerization rates. A further interest of our study is to determine the effect of the different substituents (chromophoric group) on the naphthalimide function, concerning the efficiency of initiation of the free radical polymerization. In order to improve the mechanical properties of the obtained polymers, these derivatives were also tested for the photopolymerization of a blend of acrylate/epoxy monomers (TA/EPOX); these latter properties were characterized by traction tests. To demonstrate the initiation efficiency of these dyes, several methods and characterization techniques were used, including steady state photolysis, real‐time Fourier transform infrared spectroscopy, emission spectroscopy as well as cyclic voltammetry. In our study, these naphthalimides were used for the synthesis of photocomposites (one and multiple layers of glass fibres) using a UV@395 nm (4 W/cm2) conveyor, as well as in the preparation of 3D printed polymers. Markedly, one of the naphthalimide derivatives (Napht‐4) can be used as a new high‐performance water soluble photoinitiator for photopolymerization in water and hydrogel synthesis.
On the advanced integral equation theory description of dense Yukawa one‐component plasma liquids
Authors: Castello Federico Lucco , Tolias Panagiotis 
Published: January 2021

AbstractDifferent advanced bridge function closures are utilized to investigate the structural and thermodynamic properties of dense Yukawa one‐component plasma liquids within the framework of integral equation theory. The isomorph‐based empirically modified hypernetted‐chain, the variational modified hypernetted‐chain, the Rogers–Young, and the Ballone–Pastore–Galli–Gazzillo approaches are compared at the level of thermodynamic properties, radial distribution functions, and bridge functions. The comparison, based on accuracy and computational speed, concludes that the two modified hypernetted‐chain approaches are superior and singles out the isomorph‐based variant as the most promising alternative to computer simulations of structural properties of dense Yukawa liquids. The possibility of further improvement through artificial crossover to exact asymptotic limits is studied.
Photoredox Allylation Reactions Mediated by Bismuth in Aqueous Conditions
Authors: Potenti Simone , Gualandi Andrea , Puggioli Alessio , Fermi Andrea , Bergamini Giacomo , Cozzi Pier Giorgio 
Published: January 2021

AbstractOrganometallic allylic reagents are widely used in the construction of C−C bonds by Barbier‐type reactions. In this communication, we have described a photoredox Barbier allylation of aldehydes mediated by bismuth, in absence of other metals as co‐reductants. Mild reaction conditions, tolerance of oxygen, and use of aqueous solvent make this photoredox methodology attractive for green and sustainable synthesis of homoallylic alcohols.
Thermocatalytic hydrogenation of CO2 into aromatics by tailor‐made catalysts: Recent advancements and perspectives
Authors: Wang Yang , Gao Xinhua , Wu Mingbo , Tsubaki Noritatsu 
Published: January 2021

AbstractConsidering the severe environmental issues brought by excessive carbon emissions, the utilization of CO2 as a feedstock for chemicals synthesis is gaining a lot of interest. CO2 hydrogenation into valuable chemicals using renewable energy is a promising strategy to alleviate the environmental pressures and reduce our strong dependence on fossil fuels simultaneously. Aromatics, as important chemicals in our daily life, can be synthesized by a tandem strategy that first converts CO2 into CO or methanol on Fe‐based active sites or reducible metal oxides, respectively, and then sequentially conducts CC coupling, dehydrogenation, and cyclization processes on acidic zeolites with unique topology structure for aromatics synthesis. This critical review focuses on the recent advancements in CO2 hydrogenation into high value‐added aromatics (CTA), in particular the key factors, such as the catalytic component, the acidity distribution of the zeolite, and the proximity effect between different active sites that regulate the aromatics selectivity. The reaction network and mechanism during the tandem process will be discussed to guide the rational design of highly efficient bifunctional/multifunctional catalysts for direct synthesis of aromatics by CO2 hydrogenation. Furthermore, the development directions and obstacles of CO2 utilization by hydrogenation technology will be predicted to pave the way for the practical application of greenhouse gas CO2 for valuable aromatics synthesis.image
Assessment of magnetite as a magnetic tracer for sediments in the study of ephemeral gully erosion: Conditioning factors of magnetic susceptibility
Authors: Zubieta Elena , Larrasoaña Juan C. , Aldaz Alaitz , Casalí Javier , Giménez Rafael 
Published: January 2021

AbstractIn gully erosion, the detached soil can be transported over long distances along the landscape. The eroded material can be redistributed and/or deposited on the soil surface along the landscape and then eventually be buried by newly eroded and deposited sediment. There can be significant variability of the soil conditions (e.g., texture and moisture content) over which the eroded material travels. The eroded material can be detected through the use of magnetic tracers attached to or mixed with the eroded soil. In this study we evaluated the degree to which the magnetic signal of the magnetite is conditioned by (i) burial depth of tracer, (ii) condition of soil covering the tracer and (iii) tracer concentration. In the laboratory containers were filled with a specific soil. In the filling process, a 0.5‐cm layer of a soil–magnetite mixture was interspersed in the soil profile at a certain depth. Experiments encompassed three different soil–tracer concentrations (1000:1, 200:1, 100:1), four burial depths of tracer (0 cm, 3 cm, 5 cm and 10 cm from soil surface), and two different soils. In each case, the magnetic susceptibility was measured with a susceptometer. Experiments were repeated with different soil moisture contents. If the tracer is located under the soil surface, a minimum soil–tracer concentration of 200:1 is required for its correct detection. The intensity of the magnetic signal decreases dramatically with the vertical distance of the tracer from the soil surface. The maximum detection depth for the tracer's magnetic signal is strongly dependent on the natural magnetic susceptibility of the soil, which masks the tracer's signal. Variation in soil moisture content does not significantly affect the magnetic signal. For extensive field studies, the soil–tracer volume to be handled would be very high and therefore, it is necessary to explore new tracer application techniques.
How to prevent ROP in preterm infants in Indonesia?
Authors: Siswanto Johanes Edy , Dijk Peter H. , Bos Arend F. , Sitorus Rita S. , Adisasmita Asri C. , Ronoatmodjo Sudarto , Sauer Pieter J. J. 
Published: January 2021

AbstractBackground and AimsRetinopathy of prematurity (ROP) is a severe disease in preterm infants. It is seen more frequently in Low‐Middle Income Countries (LMIC) like Indonesia compared to High‐Income Countries (HIC). Risk factors for ROP development are ‐extreme‐ preterm birth, use of oxygen, neonatal infections, respiratory problems, inadequate nutrition, and blood and exchange transfusions. In this paper, we give an overview of steps that can be taken in LMIC to prevent ROP and provide guidelines for screening and treating ROP.MethodsBased on the literature search and data obtained by us in Indonesia's studies, we propose guidelines for the prevention, screening, and treatment of ROP in preterm infants in LMIC.ResultsPrevention of ROP starts before birth with preventing preterm labor, transferring a mother who might deliver <32 weeks to a perinatal center and giving corticosteroids to mothers that might deliver <34 weeks. Newborn resuscitation must be done using room air or, in the case of very preterm infants (<29‐32 weeks) by using 30% oxygen. Respiratory problems must be prevented by starting continuous positive airway pressure (CPAP) in all preterm infants <32 weeks and in case of respiratory problems in more mature infants. If needed, the surfactant should be given in a minimally invasive manner, as ROP's lower incidence was found using this technique. The use of oxygen must be strictly regulated with a saturation monitor of 91‐95%. Infections must be prevented as much as possible. Both oral and parenteral nutrition should be started in all preterm infants on day one of life with preferably mothers' milk. Blood transfusions can be prevented by reducing the amount of blood needed for laboratory analysis.DiscussionPreterm babies should be born in facilities able to care for them optimally. The use of oxygen must be strictly regulated. ROP screening is mandatory in infants born <34 weeks, and infants who received supplemental oxygen for a prolonged period. In case of progression of ROP, immediate mandatory treatment is required.ConclusionConcerted action is needed to reduce the incidence of ROP in LMIC. "STOP ‐ R1O2P3" is an acronym that can help implement standard practices in all neonatal intensive care units in LMIC to prevent development and progression.
Cross contamination meets misclassification: Awakening of CHP‐100 from sleeping beauty sleep—A reviewed model for Ewing's sarcoma
Authors: Dirks Wilhelm Gerhard , Capes‐Davis Amanda , Eberth Sonja , Fähnrich Silke , Wilting Jörg , Nagel Stefan , Steenpass Laura , Becker Jürgen 
Published: January 2021

AbstractA human cell line of neuroblastic tissue, which was believed to have been lost to science due to its unavailability in public repositories, is revived and reclassified. In the 1970s, a triple set of neuroblastoma (NB) cell lines became available for research as MYCN‐amplified vs nonamplified models (CHP‐126/‐134 and CHP‐100, respectively). Confusingly, CHP‐100 was used in subsequent years as a model for NB and, since the 1990s, as a model for neuroepithelioma and later as a model for Ewing's sarcoma (ES), which inevitably led to non‐reproducible results. A deposit at a bioresource center revealed that globally available stocks of CHP‐100 were identical to the prominent NB cell line IMR‐32 and CHP‐100 was included into the list of misidentified cell lines. Now we report on the rediscovery of an authentic CHP‐100 cell line and provide evidence of incorrect classification during establishment. We show that CHP‐100 cells carry a t(11;22)(q24;q12) type II EWSR1‐FLI1 fusion and identify it as a classic ES. Although the question of whether CHP‐100 was a virtual and never existing cell line from the beginning is now clarified, the results of all relevant publications should be considered questionable. Neither the time of the cross‐contamination event with IMR‐32 is known nor was the final classification as a model for Ewing family of tumors available with an associated short tandem repeat profile. After a long road of errors and confusion, authentic CHP‐100 is now characterized as a type II EWSR1‐FLI1 fusion model 44 years after its establishment.
Another look at contagion across United States and European financial markets: Evidence from the credit default swaps markets
Authors: Tsionas Mike G. , Apergis Nicholas 
Published: January 2021

AbstractThe paper looks at the results of Apergis, Christou and Kynigakis (2019) and proposes a novel model that allows time variation in volatility, skewness and kurtosis, based on multivariate stable distributions. The analysis also looks at bank sector CDS, insurance sector CDS, sovereign bonds, equity and volatility indices. The findings corroborate their results and indicate significant evidence of contagion, especially through the channels of co‐skewness and co‐kurtosis. In addition, it establishes a higher order channel of causality between co‐skewness and co‐kurtosis.
RETRACTED: Isosorbide mononitrate for cervical ripening in induction of labor for pregnant women with PROM at or post term
Authors: Afifi Ahmed N. , Taymour Mohammad A. , El‐Khayat Waleed M. 
Published: January 2021

AbstractObjectiveTo evaluate the efficacy of isosorbide mononitrate (IMN) for stimulating cervical ripening among pregnant women with premature rupture of membranes (PROM) at or post term.MethodsA prospective randomized double‐blind, placebo‐controlled trial at Kasr El‐Ainy Hospital, Cairo, Egypt, from October 2018 to May 2019. Pregnant women at or post term with PROM and unfavorable cervix (Bishop score ≤6) were randomly assigned to receive intra‐vaginal IMN (n = 70) or placebo (n = 70) before admission for induction of labor. The main outcome was induction to the delivery interval. Data were compared between groups by t test.ResultsThe mean ± SD duration from the initial dose of IMN/placebo to the beginning of the active phase of labor was significantly shorter in the IMN group than in the control group (9.7 ± 5.6 h vs. 12.9 ± 5.3 h). The IMN group also had a shorter time interval from induction to delivery (P < 0.01). There was no difference in adverse effects between the groups.ConclusionIntra‐vaginal IMN for cervical ripening in the induction of labor among pregnant with PROM at or post term was found to be effective and safe with minimal adverse effects, and good neonatal and maternal outcomes.ClinicalTrials.gov: NCT03665779.
Long non‐coding RNA UCA1 correlates with elevated disease severity, Th17 cell proportion, inflammatory cytokines, and worse prognosis in acute ischemic stroke patients
Authors: Ren Bin , Song Zhiyuan , Chen Laizhao , Niu Xiaomin , Feng Qiang 
Published: January 2021

AbstractBackgroundThis study aimed to explore the association of long non‐coding RNA urothelial carcinoma‐associated 1 (lncRNA UCA1) expression with disease severity, inflammation, and prognosis in acute ischemic stroke (AIS) patients.MethodsThe lncRNA UCA1 expression of blood CD4+ T cells from 160 first‐episode AIS patients and 160 non‐AIS patients with high‐stroke‐risk factors (as controls) was detected by reverse transcription quantitative polymerase chain reaction. For AIS patients, interleukin (IL)‐6, IL‐17, and intracellular adhesion molecule‐1 (ICAM1) were determined by enzyme‐linked immunosorbent assay; Th17 cell ratio in CD4+ T cells was detected by flow cytometry. Their follow‐up data were recorded up to 36 months, recurrence of stroke or death. The recurrence‐free survival (RFS) analysis was assessed according to the follow‐up data.ResultsLncRNA UCA1 expression was higher in AIS patients compared to controls (p < 0.001), and it was positively correlated to national institute of health stroke scale score (r = 0.436, p < 0.001), Th17 cell ratio (r = 0.398, p < 0.001), IL‐6 (r = 0.204, p = 0.010), IL‐17 (r = 0.326, p < 0.001), and ICAM1 (r = 0.276, p < 0.001) in AIS patients. Regarding prognosis, lncRNA UCA1 expression was elevated in 2‐year recurrence/death AIS patients compared to those patients without recurrence or death within 2 years (p = 0.033), also increased in 3‐year recurrence/death AIS patients compared to those patients without recurrence or death within 3 years (p = 0.008). Furthermore, high lncRNA UCA1 expression was associated with worse accumulating RFS (p = 0.017) in AIS patients.ConclusionLncRNA UCA1 might sever as a candidate prognostic biomarker in AIS patients, suggesting its potency for AIS management.
Further Evaluation of Coproporphyrins as Clinical Endogenous Markers for OATP1B
Authors: Feng Sheng , Bo Qingyan , Coleman Hugh A. , Charoin Jean Eric , Zhu Mingfen , Xiao Jim , Jin Yuyan 
Published: January 2021

AbstractCoproporphyrins (CP‐I and CP‐III) in plasma are considered potential markers for assessing liver organic anion‐transporting polypeptide transporter OATP1B activity and monitoring OATP1B‐mediated drug‐drug interactions (DDIs) in clinical settings. However, the effect of altered renal clearance (CLrenal) on CP‐I and CP‐III plasma exposure has rarely been examined. Therefore, the purpose of this study is to further evaluate CP‐I and CP‐III as clinical endogenous markers for OATP1B activity and to investigate the impact of CLrenal on DDI assessments for the first time. In this study, 18 healthy participants were recruited to receive RO7049389 (a potential inhibitor of OATP1B) 800 mg twice daily for 6 days and a single dose of pitavastatin (a probe drug of OATP1B) before and after RO7049389 treatment. Plasma concentrations of pitavastatin, CP I, CP III, and the amounts of CP‐I and CP‐III excreted in urine were measured. Seventeen healthy participants completed the study. After multiple doses of RO7049389, the area under the plasma concentration–time curve from time 0 to 12 hours of pitavastatin increased 1.95‐fold (90% confidence interval [CI], 1.58‐2.41), while for CP‐I and CP‐III it increased 3.00‐fold (90%CI, 2.35‐3.82) and 2.84‐fold (90%CI, 2.22‐3.65), respectively. Concurrently, the CLrenal of CP‐I decreased by 31% (90%CI, 23%‐39%), and that of CP‐III decreased by 70% (90%CI, 61%‐77%). In conclusion, CP‐I and CP‐III in plasma display the potential to be applied as endogenous markers for the evaluation of OATP1B inhibition in clinical trials. While renal transporters contribute significantly to the CLrenal of CP‐III, it would be better to investigate the impact of the CLrenal on plasma exposure of CP‐III during clinical DDI assessments.
Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1‐targeting miRNA‐92a‐1‐5p
Authors: Yu Lijuan , Sui Bingdong , Fan Weixiao , Lei Lin , Zhou Lei , Yang Liu , Diao Yanjun , Zhang Yue , Li Zhuo , Liu Jiayun , Hao Xiaoke 
Published: January 2021

AbstractIn patients with prostate cancer (PCa), bone lesions appear osteoblastic in radiographs; however, pathological fractures frequently occur in PCa patients, and bone resorption is observed in all metastatic lesions under histopathologic assessment. The mechanisms that balance the activities of osteoblasts and osteoclasts in PCa patients remain unclear. We unexpectedly discovered that PCa exosomes are critical mediators in the regulation of bone homeostasis that results in osteoclastic lesions and thereby promotes tumor growth in bone. We evaluated how exosomes derived from osteoblastic, osteoclastic, and mixed PCa cell lines affect osteoblast and osteoclast differentiation, revealing that all three types of PCa exosomes promoted osteoclastogenesis in vitro and induced osteolysis in vivo. Mechanistically, microRNAs (miRNAs) delivered by PCa exosomes were found to play several key roles in bone homeostasis. Among the delivered miRNAs, miR‐92a‐1‐5p, the most abundant miRNA, downregulated type I collagen expression by directly targeting COL1A1, and thus promoting osteoclast differentiation and inhibiting osteoblastogenesis. Furthermore, PCa exosomes also markedly reduced type I collagen expression in vivo. Our findings not only offer a novel perspective on tumor bone metastasis, where—contrary to our initial hypothesis—exosomes derived from an osteoblastic tumor induce osteoclast differentiation, but also suggest potential therapeutic targets for PCa bone metastasis.
Gait biomechanics: A clinically relevant outcome measure for preclinical research of musculoskeletal trauma
Authors: Motherwell Jessica M. , Hendershot Brad D. , Goldman Stephen M. , Dearth Christopher L. 
Published: January 2021

AbstractTraumatic injuries to the musculoskeletal system are the most prevalent of those suffered by United States Military Service members and accounts for two‐thirds of initial hospital costs to the Department of Defense. These combat‐related wounds often leave survivors with life‐long disability and represent a significant impediment to the readiness of the fighting force. There are immense opportunities for the field of tissue engineering and regenerative medicine (TE/RM) to address these musculoskeletal injuries through regeneration of damaged tissues as a means to restore limb functionality and improve quality of life for affected individuals. Indeed, investigators have made promising advancements in the treatment for these injuries by utilizing small and large preclinical animal models to validate therapeutic efficacy of next‐generation TE/RM‐based technologies. Importantly, utilization of a comprehensive suite of functional outcome measures, particularly those designed to mimic data collected within the clinical setting, is critical for successful translation and implementation of these therapeutics. To that end, the objective of this review is to emphasize the clinical relevance and application of gait biomechanics as a functional outcome measure for preclinical research studies evaluating the efficacy of TE/RM therapies to treat traumatic musculoskeletal injuries. Specifically, common musculoskeletal injuries sustained by service members—including volumetric muscle loss, post‐traumatic osteoarthritis, and composite tissue injuries—are examined as case examples to highlight the use of gait biomechanics as an outcome measure using small and large preclinical animal models.
Effect of black chokeberry pomace extract incorporation on the physical and oxidative stability of water‐in‐oil‐in‐water emulsion
Authors: Eisinaitė Viktorija , Kazernavičiūtė Rita , Kaniauskienė Ingrida , Venskutonis Petras Rimantas , Leskauskaitė Daiva 
Published: January 2021

AbstractBACKGROUNDDespite the obvious benefits of double emulsions in reducing fat content by replacing it with the water phase, their physical and oxidative stability remains a major concern. The objective of this study was to determine the ability of black chokeberry extract to inhibit lipid oxidation during storage at 4 °C for 60 days when different amounts of the extract were added to the inner water phase of the double emulsion. In the first step, the physical stability of the emulsions was evaluated.RESULTSHigher amount of the extract caused the formation of double emulsions with smaller droplets and higher viscosity. Throughout the whole storage period, the double emulsions showed good physical stability and high encapsulation efficiency (EE) of the extract (>95%) in the inner water phase. The positive effect of the extract on the oxidative stability of the double emulsions was shown by measuring changes in peroxide values and conjugated dienes and through the Oxipres and Rancimat tests during the convenient and accelerated storage of emulsions for 60 days.CONCLUSIONThe higher amount of extract suppressed lipid oxidation to a higher extent given the significant amount of polyphenolics in the extract. © 2021 Society of Chemical Industry