bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depresión mayor en población general de Envigado (Colombia): prevalencia y factores asociados
Authors: Salas Zapata Carolina , Aguilar Gómez Mariana , Giraldo Sanchez Tomas Eduardo , Muñoz Rua María Camila , Torres Blandón Alejandra , Uribe Castaño Alejandro , Uribe Quintero Alejandra 
Published: October 2021

Introducción: La depresión afecta a más de 300 millones de personas en el mundo, es la principal causa de discapacidad y contribuye de forma importante a la carga mundial de morbilidad. Objetivo: Determinar la prevalencia y algunos factores personales, sociales y familiares asociados al trastorno de depresión mayor en población de 15 a 65 años del municipio de Envigado (Colombia) en el año 2017. Método: Estudio transversal con intención analítica, a partir de la información de 905 participantes del “Estudio Poblacional de Salud Mental, Envigado 2017”, recopilada a través de entrevistas realizadas con la World Health Organization Composite International Diagnostic Interview -CIDI-OMS. El procesamiento se realizó mediante el programa SPSS versión 23. Re­sultados: Cuatro factores explican la probabilidad de depresión mayor en el último año, en la población de estudio: el abuso de drogas diferentes al alcohol (ORaj=4,43 [1,164-16,833]), la muerte o enfermedad de un familiar cercano (ORaj=4,15 [1,583-10,880]), presentar altos niveles de resiliencia (ORaj=0,22 [0,112-0,425]) y una percepción excelente o buena de su salud mental (ORaj=0,19 [0,098-0,378]). Conclusiones: Los factores que aumentan la probabilidad de depresión mayor en la población de estudio son: abuso de drogas diferentes al alcohol y la muerte o enfermedad de un familiar de primer grado de consanguinidad; y los factores protectores son altos niveles de resiliencia y una percepción excelente o buena de la propia salud mental. Esta evidencia refuerza la necesidad de implementar programas de promoción centrados en el mejoramiento de habilidades para la vida, que propicien estrategias adecuadas frente a los desafíos.
Engineered hyporheic zones: design and applications in stream health restoration – a review
Authors: Tewari Ankit , Singh Prabhat Kumar , Gaur Shishir 
Published: October 2021

Abstract
Anthropogenic deterioration of streams and rivers has affected their surface-subsurface linkages. This has led to the degradation of hyporheic zones, a sensitive interface between a stream channel and its surrounding sediments, responsible for transforming pollutants, natural solutes and supporting benthic communities. Several authors have reported the influence of stream restoration measures on hyporheic exchanges and have called for the inclusion of hyporheic zone restorations in stream management. Engineered Hyporheic Zones (EHZ) are the creation of artificial transition areas due to induced hyporheic flows, brought about by some feature modifications done to the stream channel or its subsurface. These feature modifications and their implications have been investigated through lab experiments, outdoor flumes, modelling and field studies for several years. This paper attempts to summarize the endeavours made in the study of EHZ and its applications in water quality improvement and habitat restoration. A comprehensive review of up-to-date literature with specific focus on the influence of engineered structures on hyporheic exchanges is presented, followed by the comparison of preferences opted for different studies and their limitations. The paper ends with suggestive future scope in EHZ studies and its potential as a low cost alternative treatment technology for river restoration.
Removal performance and mechanism of typical amino acids in water by the peroxymonosulfate/Fe3O4 nanoparticles
Authors: Luo Yuye , Liu Cheng , Zhao Meiqi , Mehmood Tariq 
Published: October 2021

Abstract
Dissolved organic nitrogen (DON) as precursors of nitrogenous disinfection byproducts (N-DBPs) has become a serious issue for drinking water treatment. Here, Fe3O4/peroxymonosulfate (PMS) system was used to examine the amino acid removal and formation of N-DBPs in the system and the corresponding mechanisms. Results showed a remarked variation in removal efficiency of three typical amino acids, i.e., glutamate (78%), histidine (53%) and phenylalanine (27%) in Fe3O4/PMS system at optimum conditions (0.1 g/L Fe3O4, 1.5 mM PMS, 1 h). Notably, Fe3O4/PMS treatment led to dichloroacetonitrile (DCAN) formation caused by the chlorination of glutamate, phenylalanine and histidine being reduced by 53.3%, 9.7% and 41.9%, respectively. The degradation and subsequent N-DBPs formation in the Fe3O4/PMS system mainly depended on the types and properties of the amino acids. The formation of dichloroacetamide (DCAcAm) exhibited different trends, which may be due to the different R group structure of the three amino acids and the special aromaticity of the imidazole ring in the histidine side chain that facilitates its quick electrophilic substitution and ring-opening reaction. This study highlights that the Fe3O4/PMS system is a promising strategy to remove DON and efficiently eliminate N-DBPs formation in the drinking water treatment process depending on the amino acid type.
Surveillance of SARS-CoV-2 in extensive monitoring of municipal wastewater: key issues to yield reliable results
Authors: Cutrupi F. , Cadonna M. , Manara S. , Foladori P. 
Published: October 2021

Abstract
Several studies have detected SARS-CoV-2 in the stool of infected people as in urban wastewater. The quantification of SARS-CoV-2 in wastewater appears today as a powerful tool that can help in wastewater-based epidemiology (WBE). The goal is to improve the prediction of new waves of COVID-19 outbreaks and provide an early warning of the evolution of the infection. In this research, we highlighted some practical and scientific aspects that emerged during an extensive ongoing monitoring campaign carried out on a large number of wastewater treatment plants located in the province of Trento (North Italy) and aimed at the detection of SARS-CoV-2 in raw municipal wastewater. The open issues underline are related to the collection and storage (sampling protocol, storage and heat treatment), to the molecular analysis (enrichment phase), and to the mathematical calculation of SARS-CoV-2 load in wastewater, suitable for WBE (standard curve to obtain the concentration of genomic units and flow rate measurements). This study provides some insights that can help in the implementation of surveillance plans in other regions.
Molecular Docking of the Cardenolides of Asclepias subulata in the Human p53 Protein Reveals an Interaction in the Cleft of the Y220C Mutant
Authors: Valenzuela-Chavira Ignacio , Meneses-Sagrero Salvador , Arvizu-Flores Aldo A. , Hernández-Paredes Javier , Rascón-Valenzuela Luisa , Velázquez-Contreras Carlos A. , Robles-Zepeda Ramón E. 
Published: October 2021

Background and Objective:
The objective of the present study is to use docking and
ADME analysis to determine if the cardenolides of Asclepias subulata are potential stabilizing
drugs of the p53-Y220C mutant.

Materials and Methods:
Two different receptors, wild-type p53, and the mutant p53-Y220C, were
used for docking. Three independent stochastic series were performed, with 60,000 poses considered,
and the 30 best poses were selected. ADME analysis was performed using SwissADME.

Results:
Docking experiments revealed that corotoxigenin 3-O-glucopyranoside and calotropin interact
with the cleft, so they were considered potential stabilizers of the p53-Y220C mutant comparable
to the control drug 9H5, which was able to predict a position very similar to that already reported
in the crystallographic structure. The ADME predicted that calotropin and desglucouzarin
have more favorable pharmacokinetic parameters. Both molecules are predicted to be absorbed
from the GIT.

Conclusion:
Calotropin of A. subulata is predicted to be a potential drug for p53-Y220C, because
it binds to the cleft of the mutant and has favorable pharmacokinetic parameters. Corotoxigenin 3-
O-glucopyranoside also binds to the Y220C cleft, but had less favorable pharmacokinetic parameters.
These results have a future impact since calotropin could be used for the treatment of some
types of cancer.
The Impact of the COVID-19 Infodemic on Depression and Sleep Disorders: Focusing on Uncertainty Reduction Strategies and Level of Interpretation Theory
Authors: Jung Soyoung , Jung Sooin 
Published: October 2021

Background
During the COVID-19 pandemic, information diffusion about the COVID-19 has attracted public attention through social media. The World Health Organization declared an infodemic of COVID-19 on February 15, 2020. Misinformation and disinformation, including overwhelming amounts of information about COVID-19 on social media, could promote adverse psychological effects.

Objective
This study used the Psychological Distance and Level of Construal theory (CLT) to predict peoples’ negative psychological symptoms from social media usage. In this study, the CLT intended to show peoples’ psychological proximity to objects and events with respect to the COVID-19 pandemic. Furthermore, this study links the uncertainty reduction strategy (URS) and CLT for COVID-19–related preventive behaviors and affective reactions to assess their effects on mental health problems.

Methods
A path model was tested (N=297) with data from a web-based survey to examine how social media usage behaviors are associated with URS and psychological distance with COVID-19 (based on the CLT), leading to preventive behaviors and affective reactions. Finally, the path model was used to examine how preventive behaviors and affective reactions are associated with mental health problems including anxiety and sleep disorder.

Results
After measuring participants’ social media usage behavior, we found that an increase in general social media usage led to higher use of the URS and lower construal level on COVID-19. The URS is associated with preventive behaviors, but the CLT did not show any association with preventive behaviors; however, it increases affective reactions. Moreover, increased preventive behavior showed negative associations with symptoms of mental health problems; that is, depression and sleep disorder. However, the affective reaction tends to be positively associated with depression and sleep disorder. Owing to the infodemic of COVID-19, the psychological perception of the pandemic negatively influenced users’ mental health problems.

Conclusions
Our results imply that the information from social media usage heightened concerns and had a lower construal level; this does not facilitate taking preventive actions but rather reinforces the negative emotional reaction and mental health problems. Thus, higher URS usage is desirable.
Feasibility of Online Classes for Microbiology Courses: Lessons learned amid COVID-19 Pandemic
Authors: Khalid  Aljarallah  
Published: October 2021

Universities and colleges worldwide have been closed following the novel coronavirus (COVID-19), and online learning has become an educational practice at once. Previous research showed many problems, including time management difficulties, technological devices, communication, engagement and assessment of students for both educators and students in online education. This research was formulated to understand whether online microbiology courses from different Saudi Universities are appropriate. It was a nationwide cross-sectional study among educators from multiple Saudi Arabian Universities during the whole month of June 2020. We distributed the survey link electronically through messages on the phone. A total of 134 Saudis participated in the study, and the majority of the respondents, i.e., 106 (79.10%) are between 36 to 55 years old, 17 (12.69%) are 56 years and above. A total of 65 (48.51%) respondents responded that shifting from in-classroom to online setup has impacted the teaching-learning process negatively, while 43 (32.09%) responded with a positive impact. The majority of the respondents (82%) disagreed that practical learning outcomes such as laboratory-based microbiology courses can be achieved online at the same level as regular-campus classes.Furthermore, more than half of the participants think that students' dishonesty or violation of academic integrity threatens institutions from offering online courses. Technology tools have brought a positive impact on the effectiveness of online microbiology education. This study illustrated that the shift to online microbiology classes has a positive impact on attention to academic integrity. However, in-person labs are still considered the optimal lab design. While pandemics have historically generated difficulties, recognizing these difficulties is the first step in turning them into possibilities.
Plantarhyperhidrosis: The Efficacy Of Iontophoresis With Tap Water, Glycopyrronium Bromide And Indomethacin
Authors: Dr.C.V.Senthilnathan1  , G.Vaishnavi  , G.Keerthana  , S.NandhaKumar  , Dr.Kotteeswaran  
Published: October 2021

Hyperhidrosis is an excessive production of sweat more than the physiological amount necessary to maintain thermal homeostasis. Primary focal hyperhidrosis is a disorder of unknown etiology, causing excessive, bilateral, symmetrical sweating on the soles of the foot is called plantar hyperhidrosis. The condition results not only in physical impairment, but also interferes with professional and social life. Although not life- threatening, it is very uncomfortable and cause embarrassment and psychological trauma. Iontophoresis is a helpful method, which includes the presentation of particles into the body tissue through the skin. The essential principle is to place the ion particles under an electrode with the same charge, i.e. negative ion placed under cathode and positive ion placed under anode. This complete process is also known as “technique of ion transfer” into the body tissues by using electrical current as a driving force. It is a comparative study with pre and post intervention. 30 subjects with plantar hyperhidrosis were selected based on the inclusion criteria. The study duration was for about 4 weeks30 subjects of age group between 15 –25 years with idiopathic plantar hyperhidrosis of both male and female subjects were included in this study. Subjects with cardiac and respiratory disorders, pregnant or lactating, any cuts, abrasions, eczema or infections on plantar aspect, metal implants like pacemakers, Hypersensitivity to the active substance were excluded. The subjects were divided into 3 group Group A treated with iontophoresis using tap water alone. Group B were treated with iontophoresis using tap water along with 3%-5% of anticholinergic drug, glycopyrronium bromide solution. Group C were treated with iontophoresis using tap water along with 1% of indomethacin (NSAID). The result of this study shows that there were significant changes in outcome measures. On comparing Mean values of Group A, Group B & Group C on Minor test (Starch - Iodine Test) tap Water along with Glycopyrronium Bromide (Group B) shows 1.60 which has the Lower Mean value is effective than Group A and Group C .On comparing Mean values of Group A, Group B & Group C on Visual Analog Scale score tap Water along with Glycopyrronium Bromide (Group B) shows 3.80 which has the Lower Mean value is effective than Group A and Group C. On comparing Mean values of Group A, Group B & Group C on Hyperhidrosis Disease Severity Scale tap Water along with Glycopyrronium Bromide (Group B) shows 1.40 which has the Lower Mean value is effective than Group A and Group C. On comparing all the three groups, Group B shows better result than Group C and Group A in outcome measure. This study concluded that Tap water along with glycopyrronium bromide reduces the excessive sweating and decrease the sweating symptoms in subjects with plantar hyperhidrosis.
A Novel Analytical Method for the Estimation of Solriamfetol in Plasma Samples by Lc-Ms/Ms
Authors: Perina.Ratnakumari  , N.Kannappan  , P.Premkumar  
Published: October 2021

Solriamfetol is a selective dopamine and norepinephrine reuptake inhibitor with wake‐promoting effects. The aim of the present study is to develop a rapid, sensitive and reliable method for the estimation of Solriamfetol in plasma samples using LC-MS. In the present investigation, a rapid, specific, selective and novel method has been optimized for evaluation of solriamfetol in in plasma using modafinil as an internal standard and identification of degradants by LC-MS/MS. The solriamfetol and internal standard were extracted from plasma in a single step using acetonitrile. The principle analytes were eluted with the conditions of mobile phase having the 5mM ammonium format in methanol: 50% Methanol in acetonitrile (90:10%, v/v). The Chromatographic column used is Xterra MS C18, 3.5µ.m, 1mmX150mm analytical column with the 0.5 ml/min flow rate. The detector is CEM array detector. The retention times of solriamfetol and modafinil were 1.50min-1.51min with a total run time of 3 min. The curve indicates correlation coefficient (r2) for modafinil was superior by having the value 1.000 with linear range of 5ng/ml to 500ng/ml. The correlation coefficient (r2) for solriamfetol was found to be 0.999. The LOQ and LOD for the solriamfetol was 33.70pg/ml and 11.12pg/ml respectively The developed method was validated by evaluating system suitability, selectivity, sensitivity, linearity, precision, accuracy, ruggedness and stability in conformity with the guidelines of the United States Food and Drug Administration (US-FDA). The results of validation parameters were found to be within the acceptance limits. Hence, the developed and validated method can be utilized for the routine determination of solriamfetol in plasma samples.
In Silico Prediction, Computational Physico Chemical Analysis in Gymnemic Acids
Authors: Dhanapal Indumathi  , Ramasamy Sujatha  , Palanisamy Shanmuga Sundaram  
Published: October 2021

Gymnema sylvestre (Asclepiadaceae) also known as ‘gurmar’ or ‘sugar destroyer’ is a woody, climbing traditional medicinal herb which has many therapeutic applications in the Ayurvedic system of medicine. We present an overview of the most important databases with 2 gymnemic acid structural information about drugs and drug candidates, and of databases with relevant properties. Access to experimental data and numerical methods for selecting and utilizing these data is crucial for developing accurate predictive in silico models. Many interesting predictive methods for classifying the suitability of chemical compounds as potential drugs, as well as for predicting their physico-chemical and ADMET properties have been proposed in recent years. The gymnemic acids act as therapeutic agents and play vital roles in many therapeutic applications. Gymnemic acids are thought to be responsible for its anti-diabetic activity and are the major component of an extract shown to stimulate insulin release. It is also screened for bioavailability study, physicochemical study, drug likeness study, medicinal chemical analysis and target prediction. These methods are discussed, and some possible future directions in this rapidly developing field are also described. The commercial exploitation of this plant and its secondary metabolites are some of the major perspectives of this rare medicinal herb. The focus of the present study is to achieve the potential of therapeutic value of this herb its mechanism,and the action of their secondary metabolites.
The Effect of Occupational Health and Safety Practices on Organization Trust in Hotel Businesses
Authors: Dr. Ebru  Kemer  , Bilal Çilkaya  , Aynur Topal  
Published: October 2021

This research, is aimed to determine the effect of occupational health and safety practices in hotel businesses in Nevşehir province on the perceptions of employees' trust in the organization. For this purpose, data were collected from employees working in hotel businesses in Nevşehir province from February to May 2021 by survey technique. In the study, correlation analysis was applied to determine the relationship between occupational health and safety practices of hotel businesses and their perceptions of trust in the organization, and regression analysis was applied to determine the effect of occupational health and safety practices on trust in the organization. As a result of the research, it has been determined that the perception of trust in the organization of the employees of hotel enterprises is affected by occupational health and safety practices. Occupational health and safety, gaining more importance with each passing day, plays a decisive role for both developed countries and developing countries. Changes in working life also have an impact on occupational health and safety, and changing working conditions bring new risks and dangers. For this reason, with new regulations, states, employers, and employees need to keep occupational health and safety up to date. Practices at the point of working conditions, employment contracts, working methods (trial-term, part-time, seasonal, on-call work, overwork, unregistered employment, etc.) of the enterprises in the tourism sector are important for the sector employees and must be taken under legal supervision and protection.
Analysis of Codon Usage Pattern and Predicted Gene Expression in Neurospora Crassa: A Novel in Silico Approach
Authors: Satyabrata Sahoo  
Published: October 2021

The codon usage pattern of genes has a key role in the gene expression and adaptive evolution of an organism. It is very significant in understanding the role of complex genomic structure in defining cell fates and regulating diverse biological functions. In this paper, we discussed that the codon usage index (CAIg) based on all protein-coding genes is a promising alternative to the Codon Adaptation Index (CAI). CAIg which measures the extent that a gene uses a subset of preferred codons relies exclusively on sequence features and is used as a good indicator of the strength of codon bias. A critical analysis of predicted highly expressed (PHE) genes in Neurospora crassa has been performed using codon usage index (CAIg) as a numerical estimator of gene expression level. Analyzing compositional properties and codon usage pattern of genes in Neurospora crassa, our study indicates that codon composition plays an important role in the regulation of gene expression. We found a systematic strong correlation between CAIg and CBI (codon bias index) or other expression-measures. Here, we show that codon usage index CAIg correlates well with both protein and mRNA levels; suggesting that codon usage is an important determinant of gene expression. Our study highlights the relationship between gene expression and compositional signature in relation to codon usage bias in Neurospora crassa and sets the ground for future investigation in eukaryotic biology.