bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptomic Analysis of Healthy and Atopic Dermatitis Samples Reveals the Role of IL-37 in Human Skin
Authors: Zhou Jiajun , Gemperline David C , Turner Matthew J , Oldach Jonathan , Molignano Jennifer , Sims Jonathan T , Stayrook Keith R 
Published: October 2021

Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects up to one in five children and millions of adults in developed countries. Clinically, AD skin lesions manifest as subacute and/or chronic lichenified eczematous plaques, which are often intensely pruritic and prone to secondary bacterial and viral infections. Despite the emergence of novel therapeutic agents, treatment options and outcomes for AD remain suboptimal. An improved understanding of AD pathogenesis may help improve patient outcomes. Dysregulated Th2-polarized skin inflammation and impaired skin barrier function interact to drive AD pathogenesis; however, much remains to be understood about the molecular mechanisms underlying this interplay. The current study used published clinical trial datasets to define a skin-related AD gene signature. This meta-analysis revealed significant reductions in IL1F7 transcripts (encodes IL-37) in AD patient samples. Reduced IL1F7 correlated with lower transcripts for key skin barrier function genes in the epidermal differentiation complex. Immunohistochemical analysis of normal (healthy) human skin specimens and an in vitro three-dimensional human skin model localized IL-37 protein to the epidermis. In comparison with normal human skin, IL-37 levels were decreased in AD patient skin. Addition of Th2 cytokines to the aforementioned in vitro three-dimensional skin model recapitulates key aspects of AD skin and was sufficient to reduce epidermal IL-37 levels. Image analysis also indicated close relationship between epidermal IL-37 and skin epidermal differentiation complex proteins. These findings suggest IL-37 is intimately linked to normal keratinocyte differentiation and barrier function and implicates IL-37 as a potential biomarker and therapeutic target for AD.
Efectos de la radiación electromagnética: Un estudio de caso
Authors: Benito Paula Andrea Benito , Torres Manuel Yecid Fernandez , Cetina Jhonny Orlando Tolosa 
Published: October 2021

En este trabajo se analizan los efectos biológicos de las radiaciones electromagnéticas a partir de la recopilación y comparación de fuentes bibliográficas que evidencian el estudio de dicho fenómeno físico, analizado mediante una metodología cualitativa basada en la revisión bibliográfica de trabajos que reportan aspectos fundamentales del tema en cuestión y examinados por medio de una matriz de análisis que recoge los puntos de vista más importantes de cada investigación. Dentro de los resultados obtenidos no hay coincidencia, ya que algunos autores apoyan la idea de que estas radiaciones son perjudiciales para la salud humana, mientras que otros no descartan la posibilidad de que estas puedan ser inofensivas para el ser humano, pero sin desechar el riesgo de que a largo plazo puedan generar problemas de salud. Después de realizar las evaluaciones correspondientes y utilizar los métodos ya mencionados con anterioridad, se concluye que las radiaciones electromagnéticas pueden llegar a ser perjudiciales para la salud humana a exposiciones prolongadas, por esto se advierte sobre posibles enfermedades y se dan recomendaciones al respecto.

This work analyzes the biological effects of electromagnetic radiation based on the compilation and comparison of bibliographic sources that evidence the study of this physical phenomenon, analyzed by means of a qualitative methodology based on the bibliographic review of works that report fundamental aspects of the subject in question and examined by means of an analysis matrix that gathers the most important points of view of each research. Within the results obtained there is no coincidence, since some authors support the idea that these radiations are harmful to human health, while others do not rule out the possibility that they may be harmless to humans, but without discarding the risk that in the long term they may generate health problems. After performing the corresponding evaluations and using the methods mentioned above, it is concluded that electromagnetic radiations may be harmful to human health with prolonged exposure, and for this reason a warning is given about possible diseases and recommendations are given in this regard.
Ensino de genética no ensino médio: uma análise estatística das concepções prévias de estudantes pré-universitários
Authors: Belmiro Michel Stórquio , Monteiro de Barros Marcelo Diniz 
Published: October 2021

Devido a crescentes avanços da genética, cada vez mais é necessário o conhecimento para a tomada de decisões pelos cidadãos. A escola tem um papel crucial nesse processo de construção do conhecimento, embora tenha se mostrado falho em diversos aspectos. O objetivo desse estudo foi investigar as concepções prévias de estudantes do ensino médio sobre conceitos fundamentais em genética. A investigação mostrou que a maioria dos estudantes apresentava concepções errôneas do ponto de vista científico. Este fato pode estar relacionado à descontinuidade no processo de ensino-aprendizagem. Assim, um diagnóstico através da identificação das concepções dos estudantes pode ajudar o educador a alcançar melhores resultados no processo de aprendizagem, pois existe a possibilidade de melhor adaptação do assunto às dificuldades dos estudantes, principalmente no atual momento de discussão e planejamento de uma base nacional comum curricular (BNCC).
Uma experiência com Think Pair Share no Ensino Fundamental I
Authors: Moreno Vaz dos Reis Angelina Fatima , Motta Barreto Maria Auxiliadora 
Published: October 2021

Este artigo é resultado da pesquisa de dissertação de mestrado que se propôs a investigar as possíveis contribuições da Metodolgia Ativa Think Pair Share no Ensino Fundamental I. As Metodologias Ativas de Aprendizagem são estratégias de ensino que visam a mobilizar o aluno para a construção do próprio conhecimento de forma mais proativa e menos receptora. Para aplicação da metodologia foi desenvolvida uma sequência de atividades com o tema astronomia com ênfase para o tópico lua, em que os alunos deveriam pensar em conjunto, discutir em pares e efetuar relações com a mediação do professor. O desenvolvimento desta estratégia foi considerado positivo, pois os alunos se mostraram engajados nas atividades e responderam satisfatoriamente a ela. Foi constatada escassez de material de pesquisa sobre metodologias ativas aplicado ao Ensino Fundamental I no Brasil, o que sinaliza a necessidade de aprofundar as práticas e efetuar um registro reflexivo sistemático sobre as mesmas.Palavras –chaves: Metodologias ativas, think pair share, ensino fundamental I
A study of metabolic syndrome and its association with demographic, anthropometric and biochemical parameters
Authors: T Jaseem , Abraham Rebecca , M. K. Dinesh Kumar , Kumari Beena , Joice Sangeetha V. 
Published: October 2021

Introduction and Aim: Metabolic syndrome (Mets) is a constellation of interrelated metabolic rearrangements like obesity, hypertension,hyperglycemia,and dyslipidemia whichcan predispose to a greater risk of developing cardiovascular events. This study is aimed to assess the demographic profile of Mets in rural Calicut of Southern India.

Materials and Methods:This study was carried outover a period of one year in a tertiary care teaching hospital. Anthropometric measurements (height, weight, waist circumference) and bloodpressure were taken. Fasting blood samples were analyzed to measure glucose, triglyceride, high-density lipoprotein cholesterol and thyroid-stimulating hormone.

Results: Out of the randomly selected 650 patients, 347 (53.3%) were males and 303(46.6%) were females,adopting the National Cholesterol Education Program Adult Treatment Panel III criteria (NCEP ATP III)Mets was more prevalent infemales than in men (34.32% v/s 14.12 %). Maximum numbers of Mets cases were in the age range of 50–59 years followed by 40–49 years. Among the 153 cases of Mets,decreased high-density lipoproteinwas the most common (99 %) among females and hyperglycemia (51%) among males.

Conclusion: The prevalence of MetSin the <50years’ age group is rapidly increasing. It's high time to be more active physically beforethe onset of any fatal cardiovascular events.
El cristianismo ante el siglo XXI en América Latina. Una reflexión desde las víctimas
Authors: Sobrino Jon 
Published: October 2021

Ante este siglo XXI real, el cristianismo tiene que preguntarse qué hacer. Lo primero ya lo hemos hecho: pasar juicio sobre este mundo desde las víctimas. Pero, más allá de eso, hay que preguntarse qué ser y qué hacer en y con ese mundo. En este sentido, la perspectiva del autor es la de los pobres y víctimas de este mundo y, aceptando las novedades alrededor del cambio de siglo, quiere desmitificarlas un poco. Así, visto desde las víctimas, el siglo XXI ya empezó en 1989, con la caída del este. Y por lo que toca al cristianismo, su gran novedad -que sigue siendo lo más novedoso- comenzó en 1968 con Medellín.
ECA Estudios Centroamericanos, Vol. 55, No. 615-616, 2000: 79-93.
E-LEARNING MARKET FOR EDTECH STARTUPS AFTER COVID-19 IN INDIA
Authors: Bansal Dr. Monika , Mehra Dr.Yogieta S 
Published: October 2021

Classroom teaching at every level viz., schools, higher education, coaching, and certifications saw a major setback due to pandemic COVID-19. Complete shutdown of classrooms was need of the hour to stop the spread of coronavirus. The current paper is an attempt to understand the various opportunities posed by pandemic for Edtech startups.
This paper attempts to understand the growth trends and growth drivers of Edtech industry in India. Current and popular Indian Edtech startups were reviewed to understand the market for Edtech companies. A survey was conducted to understand the perception of people towards Edtech startups with reference to their awareness level, satisfaction, customer database and market growth. Results have shown that digital learning has substantial potential to grow post- pandemic as well. The results here confirm the worth of EdTech startups in the current pandemic situation, and even after.
Feminización de la Carrera de Medicina: Facultad de Medicina de la Universidad de Iberoamérica 1995-2015
Authors: Calvo Fonseca María del Rosario , Padilla Cuadra Juan Ignacio 
Published: October 2021

Introducción: Las desigualdades en el acceso a la educación superior se deben a actores geográficos, económicos-sociales, religiosos, étnicos y género. La carrera de medicina ha mostrado recientemente una tendencia al predominio del sexo femenino entre sus estudiantes y graduados, fenómeno denominado feminización de esta carrera.
Assessment on spatial extent of arid and semi-arid climatic zones of India using GIS
Authors: NISHA SAHU  , G. P. OBI REDDY  , B. DASH  , NIRMAL KUMAR  , S. K. SINGH  
Published: October 2021

In this study, a quantitative assessment of spatial extent of arid and semi-arid climatic zones of India was performed for the period from 1988 to 2018 using potential evapo-transpiration (PET) calculated by Modified Penman Method, estimated from global climate data sets. Climatic water balances computed for 625 stations across the country are used for classifying to bio-climate types based on moisture index and areas falling under arid climatic zones in India are delineated using ArcGIS 10.5. It was noticed a considerable changes in the country’s arid and semi-arid climatic zones between the two periods; 1992 and 2018. Overall, there has been a net percent change in hyper arid, typic arid and semi arid (dry) areas is 5.62, 1.62 and 7.17 percent, respectively. Dryness and wetness are increasing in different parts of the country. There is also change in rainfall, PET and moisture index over a period of time which is vital to determine aridity pattern of any region. Thus, results are of great significance for studying the assessment of temporal and spatial dry climatic water balance of India, which can help immensely in the management of water resources and sustainability of crop production under changing climatic conditions.
EFFECTS OF INFILL WALLS ON BUILDING BEHAVIOUR UNDER SEISMIC LOADS
Authors: Dorji Lobzang 
Published: October 2021

In the design of Reinforced Concrete (RC) building, infill walls are normally assumed as non-structural elements and they are accepted as vertical uniform loads on beams. Therefore, the RC buildings are designed as bare frame structures. However, in reality, infill walls are present in RC buildings, and the seismic performance of the buildings will be different with and without infill walls. In this study, 5 storey RC buildings with 2 bays and 5 bays in X-direction and Y-direction respectively are considered. The infill walls were replaced as equivalent diagonal struts and the non-linear static pushover analysis was performed to evaluate the effects of infill walls on the overall performance of the structures. The lateral strength capacity and performance point of the building were determined for the conventional (bare frame) method and with the presence of infill walls. The study reveals that the effects of infill walls under seismic loads in significant until elastic region in which the initial stiffness and strength of the structures increases, while lateral deformation capacity decreases. It is also observed that there are no significant changes in terms of ultimate lateral strength and roof displacement of the building as compared within presence of infill walls and bare frame.
Del mito a la viralidad
Authors: Palomo-Domínguez Isabel 
Published: October 2021

Tema principal del artículo: El mito es un recurso ancestral, tradicionalmente usado en la publicidad. El deepfake, una tecnología novedosa y polémica que abre un extraordinario horizonte creativo. La antigüedad del mito y la innovación del deepfake pueden combinarse para crear un mensaje de marca capaz de alcanzar una extraordinaria difusión viral.
Desarrollo lógico del tema: En enero de 2021, la marca cervecera Cruzcampo lanzó una campaña publicitaria protagonizada por Lola Flores, artista española de fama internacional fallecida en 1995. En cuestión de horas, la campaña batió récords de difusión en los medios digitales. Su principal peculiaridad fue el uso del deepfake para ‘devolver a la vida’ a la mítica artista, así como poner en su boca un mensaje reivindicativo, que movilizaba al público a defender su acento.
Punto de vista y aportaciones de los autores: Realizamos un ejercicio de análisis de la campaña para reflexionar sobre la función del mito y los demás factores que han favorecido su viralidad. También observamos este caso como ejemplo de la transformación de las figuras del anunciante y la agencia en el sector publicitario actual. Para enriquecer la reflexión, aportamos información primaria obtenida a través de una doble metodología: una investigación cualitativa (entrevistas), para conocer la estrategia y proceso de creación; y una investigación cuantitativa (cuestionario) para medir el alcance del mensaje y la contribución de los usuarios en su difusión.
Repercusiones y conclusiones: El análisis de esta campaña muestra los elementos estratégicos que han permitido generar sinergias entre el mito y las nuevas tendencias en comunicación digital, tales como la tecnología deepfake, la transmedialidad, o una estrategia de branding inspirada en un concepto de RSC. En este sentido, aporta información relevante como caso de éxito, que podrá ser de interés para investigadores y el sector de la publicidad.
Formación en reputación. Análisis de los principales MBA en México
Authors: Santana Villegas José Rafael 
Published: October 2021

Objetivo: En el presente artículo se exponen los resultados obtenidos al realizar un análisis cuyo objetivo principal fue conocer el estado que guarda la capacitación ejecutiva en México en materia de reputación, realizando para ello, una revisión de los planes curriculares de los cursos de formación ejecutiva por excelencia: los MBA, de manera que se pueda conocer cuánto del contenido de dichos programas está orientado a capacitar a los ejecutivos en la gestión de dicho intangible.
Diseño/metodología/enfoque: Para lograr lo anterior, se ha realizado un análisis de contenido de los planes curriculares de los cursos que han aparecido ininterrumpidamente en un periodo de seis años, en el ranking de los mejores MBA que edita la Revista Expansión en México, revisando también bibliografía relativa al papel que juega la alta dirección en la gestión de la reputación.
Resultados: El análisis realizado demuestra que las asignaturas impartidas en los principales cursos de MBA ofrecidos en México se centran en capacitar en áreas relacionadas a la práctica empresarial tradicional, pero no capacitan a los altos ejecutivos en la mayoría de las competencias necesarias para gestionar de manera adecuada la reputación.
Limitaciones/implicaciones: El trabajo presenta áreas de oportunidad para la formación ejecutiva en México a través de los programas de MBA; sin embargo, debe considerarse como un punto de partida para estudios posteriores en los que se aborde el tema desde otros ángulos, en los que se consideren también opiniones de altos ejecutivos, consultores y directores académicos de los programas de MBA.
Originalidad/contribución: Esta investigación pretende contribuir a mejorar la formación que reciben actualmente los altos ejecutivos en este país, de manera que puedan estar más capacitados para enfrentar los retos que presenta el entorno actual para los negocios.
Assessment of Knowledge, Attitude and Practice towards Disposal of in-Home Medication among Community in Eastern Province, Saudi Arabia
Authors: Ali Mohammad Daud , Ahmad Ayaz , Kannan Latha Subarayan , Lewis Sharell , Suliaman Zainab Salman Al , Almanasif Fatimah Dyia , Alnabi Zainab Abdulmonem Abdrab 
Published: October 2021

Aim: Current study conducted with aims to assess general public knowledge, attitude and practice towards disposal of in-home medication among community in Eastern province, Saudi Arabia.
Methods: A cross-sectional survey-based study was conducted from 1st September 2019 to 31st October 2019 among the community in Eastern province, Saudi Arabia. A validated self-administered questionnaire was distributed to easily approachable 1400 participants through social media in which 916 respondents were completely filled the survey form. Chi square test were used for the calculation of variance among the group. P-value less than and equal to 0.05 is considered statistically significant.
Results: The response rate of survey was 65.42%.The mean age of the survey respondents was 30.34 ±9.95 years. Among all the respondents 225(24.56%) respondents were male and 691(75.43%) respondents were female from community of Eastern province, Saudi Arabia. The majority of the respondents 709 (77.4%) (p<0.05) purchased the medicines on prescription. The majority of the respondents 763 (84.8%) (p<0.05) answered that improper disposal of unused and expired medicines causes damage of environment and health. The results revealed that the most common Over the counter (OTC) drugs as follows, analgesics with 456 (49.78%)(p<0.05), Vitamins & Minerals 272 (29.69%), Cold and flu Drugs 84 (9.17%), Food Supplements 56 (6.11%) and in the last Digestive drugs with 48 (5.24%).
Conclusion: Gaps persist in practices, hence vigorous, safe and cost-effective pharmaceutical waste management program reinforced campaign is required. Healthcare providers (HCPs) and community pharmacists (CPs) should organize training to educate customers on standard medicine disposal practices.
Comparison of the Effect of Percutaneous Tibial Nerve Stimulation (PTNS) with Medical Treatment in Patients with Overactive Bladder
Authors: Nikoo Mohammadreza , Majidi Lobat , Heidari Amirmohammad , Jafarvand Babak , Aghabozorgi Danial , Nikbakht Nikta 
Published: October 2021

Introduction: Overactive bladder (OAB) is a common problem that involves therapeutic challenges. Therefore, finding new and effective treatment modalities in these patients is essential. The aim of this study was to compare the therapeutic effect of percutaneous tibial nerve stimulation (PTNS) with drug therapy in patients with OAB.
Methods: In this randomized controlled clinical trial, 74 patients with OAB were randomly divided into two groups: PTNS (twice a week for 12 weeks) and drug treatment (Solifenacin 10 mg daily for 12 weeks). OAB Symptom Score, q-OAB and Health-Related Quality of Life Questionnaire (HRQL) were completed and then compared at the beginning and end of the study for the two groups. Findings were analyzed using SPSS software version 20.
Results: The drug intervention group consisted of 33 (89.2%) females and 4 males (10.81%), and PTNS group consisted of 31 females (83.8%) and 6 males (16.21%), (P = 0.496). Mean quality of life score, mean OABSS score, OAB screening score and urinary incontinence in both groups before the intervention did not show a statistically significant difference. After treatment, the mean quality of life in both groups increased significantly compared to before the intervention, but this increase was significantly higher in PTNS when compared with other group (74.2±6.9 vs. 68.9± 7.3). The mean OABSS score, OAB screening score and urinary incontinence in both groups decreased significantly compared to before treatment, but the mean OABSS score and OAB and urinary incontinence screening scores showed a significant decrease in PTNS group compared to drug treatment.
Conclusion: Based on the findings, PTNS was found to be more effective than drug treatment in increasing the quality of life and controlling symptoms of OAB.
Recent Adventures in Beryllium Chemistry
Authors: Walley Jacob E. , Gilliard Robert J. 
Published: October 2021

Abstract
One of the least understood elements on the periodic table is beryllium, perhaps a result of the presumed toxicity of its complexes. Despite this limitation, beryllium exhibits a unique set of properties which sets it apart from its heavier alkaline earth congeners (Mg, Ca, Sr, Ba). Nevertheless, within the past five years, there have been a series of major advances in the field of organometallic beryllium chemistry. This article will highlight these advances by analyzing new oxidation states, reactivity, and bonding modes, targeting an audience of general synthetic chemists, including scientists at the undergraduate and graduate level.
Electrochemical Instrumentation
Authors: Leonard Kevin C. , Seuferling Tess 
Published: October 2021

Abstract
This chapter provides an overview of the instrumentation used by an electrochemist. In the study of electrochemistry, it is important to accurately control and measure both the flow and energy of electrons. We begin with an overview of the fundamentals—basics of electricity and circuits. Then, with that foundation, we cover the most essential of electrochemical instruments: the potentiostat. From the configurations to the inner workings of a potentiostat, this information should give the reader an overview of how a potentiostat collects the data. This chapter also introduces the bipotentiostat and galvanostat. Next, all things data‐related are covered, from acquisition to the various digital and analog instrumentation specifications that can affect results. Another important topic related to electrochemical instrumentation is ohmic drop. The two main methods of addressing ohmic drop are current interruption and positive feedback, which are introduced here. Additionally, the specifications and modifications for potentiostats are presented for consideration when getting started. Finally, we leave you with some thoughts on hybrid instrumentation such as scanning probe techniques and in situ techniques. We hope electrochemists new, and seasoned, can glean information to perform experiments that yield precise, accurate, high resolution data.