bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reductions in vancomycin and meropenem following the implementation of a febrile neutropenia management algorithm in hospitalized adults: An interrupted time series analysis
Authors: Trinh Trang D. , Strnad Luke , Damon Lloyd , Dzundza John H. , Graff Larissa R. , Griffith Laura M. , Hilts-Horeczko Alexandra , Olin Rebecca , Shenoy Samantha , DeVoe Catherine , Wang Lusha , Rodriguez-Monguio Rosa , Gu Tina M. , Hampton Scott R. , Macapinlac Brian Allan C. , Yang Katherine , Doernberg Sarah B. 
Published: January 2021

AbstractObjective:To evaluate broad-spectrum intravenous antibiotic use before and after the implementation of a revised febrile neutropenia management algorithm in a population of adults with hematologic malignancies.Design:Quasi-experimental study.Setting and population:Patients admitted between 2014 and 2018 to the Adult Malignant Hematology service of an acute-care hospital in the United States.Methods:Aggregate data for adult malignant hematology service were obtained for population-level antibiotic use: days of therapy (DOT), C. difficile infections, bacterial bloodstream infections, intensive care unit (ICU) length of stay, and in-hospital mortality. All rates are reported per 1,000 patient days before the implementation of an febrile neutropenia management algorithm (July 2014–May 2016) and after the intervention (June 2016–December 2018). These data were compared using interrupted time series analysis.Results:In total, 2,014 patients comprised 6,788 encounters and 89,612 patient days during the study period. Broad-spectrum intravenous (IV) antibiotic use decreased by 5.7% with immediate reductions in meropenem and vancomycin use by 22 (P = .02) and 15 (P = .001) DOT per 1,000 patient days, respectively. Bacterial bloodstream infection rates significantly increased following algorithm implementation. No differences were observed in the use of other antibiotics or safety outcomes including C. difficile infection, ICU length of stay, and in-hospital mortality.Conclusions:Reductions in vancomycin and meropenem were observed following the implementation of a more stringent febrile neutropenia management algorithm, without evidence of adverse outcomes. Successful implementation occurred through a collaborative effort and continues to be a core reinforcement strategy at our institution. Future studies evaluating patient-level data may identify further stewardship opportunities in this population.
Mass severe acute respiratory coronavirus 2 (SARS-CoV-2) testing of asymptomatic healthcare personnel
Authors: Roberts Scott C. , Peaper David R. , Thorne Craig D. , Sussman L. Scott , Murray Thomas S. , Choi Steven J. , Pettker Christian M. , Russi Mark B. , Martinello Richard A. 
Published: January 2021

AbstractMass asymptomatic SARS-CoV-2 nucleic acid amplified testing of healthcare personnel (HCP) was performed at a large tertiary health system. A low period-prevalence of positive HCP was observed. Of those who tested positive, half had mild symptoms in retrospect. HCP with even mild symptoms should be isolated and tested.
give as a put verb in German – A case of German-Czech language contact?
Authors: Lenz Alexandra N. , Fleißner Fabian , Kim Agnes , Newerkla Stefan Michael 
Published: January 2021

AbstractThis contribution focuses on the use of geben ‘give’ as a put verb in Upper German dialects in Austria from a historical and a recent perspective. On the basis of comprehensive historical and contemporary data from German varieties and Slavic languages our analyses provide evidence for the central hypothesis that this phenomenon traces back to language contact with Czech as already suggested by various scholars in the 19th century. This assumption is also supported by the fact that Czech dát ‘give’ in put function has been accounted for since the Old Czech period as well as by its high frequency in both formal and informal Czech written texts. Moreover, our data analyses show that geben ‘give’ as a put verb has been and is still areally distributed along and spreading from the contact area of Czech and Upper German varieties.
BOUNDNESS OF INTERSECTION NUMBERS FOR ACTIONS BY TWO-DIMENSIONAL BIHOLOMORPHISMS
Authors: Ribón Javier 
Published: January 2021

AbstractWe say that a group G of local (maybe formal) biholomorphisms satisfies the uniform intersection property if the intersection multiplicity

$(\phi (V), W)$
takes only finitely many values as a function of G for any choice of analytic sets V and W of complementary dimension. In dimension

$2$
we show that G satisfies the uniform intersection property if and only if it is finitely determined – that is, if there exists a natural number k such that different elements of G have different Taylor expansions of degree k at the origin. We also prove that G is finitely determined if and only if the action of G on the space of germs of analytic curves has discrete orbits.
Beethoven's String Quintet in C major, Op. 29, and Brahms's String Sextets: A Wallflower Blooms
Authors: Horne William 
Published: January 2021

Beethoven's String Quintet, Op. 29, has been described as a ‘wallflower’ work that, without enough suitors, remains on the sidelines of the string chamber music repertoire. But in the nineteenth century it had a prominent champion, Joseph Joachim, whose performances of the quintet must have attracted the attention of his close friend, Johannes Brahms. The opening theme of Brahms's String Sextet, Op. 18, is clearly reminiscent of the beginning of Beethoven's quintet. Evidence from Donald Francis Tovey's recollections of Joachim, Joachim's correspondence with the Brahms biographer Max Kalbeck, and the manuscript of Op. 18 shows that Joachim influenced an important revision that aligns the beginning of Brahms's sextet closely with the opening of Beethoven's Op. 29 also in terms of texture and formal design.The striking tremolo opening and virtuosic scale passages in the finale of Beethoven's quintet prefigure similar elements in the last movement of Brahms's Op. 36 sextet. But the deeper relationship between these movements lies in certain shared formal elements: a common emphasis on sound, texture and sharp contrasts between agitato and pastoral elements as defining features of the overall form – and several distinctive similarities of contrapuntal strategy, form and tonal design between the substantial fugatos that dominate the development sections of both movements.It is often observed that Brahms wrote chamber works in pairs. Scholars have often posited that his two string sextets form such a pair, but the separation of four years in their inceptions and his extensive use of Baroque-style materials composed in the 1850s in the later sextet have made this argument tenuous. It now emerges that an unusual pairing feature of Brahms's string sextets is that both works respond to Beethoven's ‘wallflower’ masterpiece.
Multiple herbicide-resistant Palmer amaranth (Amaranthus palmeri) in Connecticut: confirmation and response to POST herbicides
Authors: Aulakh Jatinder S. , Chahal Parminder S. , Kumar Vipan , Price Andrew J. , Guillard Karl 
Published: January 2021

AbstractPalmer amaranth is the latest pigweed species documented in Connecticut; it was identified there in 2019. In a single-dose experiment, the Connecticut Palmer amaranth biotype survived the field-use rates of glyphosate (840 g ae ha−1) and imazaquin (137 g ai ha−1) herbicides applied separately. Additional experiments were conducted to (1) determine the level of resistance to glyphosate and acetolactate synthase (ALS) inhibitors in the Connecticut-resistant (CT-Res) biotype using whole-plant dose-response bioassays, and (2) evaluate the response of the CT-Res biotype to POST herbicides commonly used in Connecticut cropping systems. Based on the effective dose required for 90% control (ED90), the CT-Res biotype was 10-fold resistant to glyphosate when compared with the Kansas-susceptible (KS-Sus) biotype. Furthermore, the CT-Res biotype was highly resistant to ALS-inhibitor herbicides; only 18% control was achieved with 2,196 g ai ha−1 imazaquin. The CT-Res biotype was also cross-resistant to other ALS-inhibitor herbicides, including chlorimuron-ethyl (13.1 g ai ha−1), halosulfuron-methyl (70 g ai ha−1), and sulfometuron-methyl (392 g ai ha−1). The CT-Res Palmer amaranth was controlled 75% to 100% at 21 d after treatment (DAT) with POST applications of 2,4-D (386 g ae ha−1), carfentrazone-ethyl (34 g ai ha−1), clopyralid (280 g ae ha−1), dicamba (280 g ae ha−1), glufosinate (595 g ai ha−1), lactofen (220 g ai ha−1), oxyfluorfen (1,121g ai ha−1), and mesotrione (105 g ai ha−1) herbicides. Atrazine (2,240 g ai ha−1) controlled the CT-Res biotype only 52%, suggesting the biotype is resistant to this herbicide as well. Here we report the first case of Palmer amaranth from Connecticut with multiple resistance to glyphosate and ALS inhibitors. Growers should proactively use all available weed control tactics, including the use of effective PRE and alternative POST herbicides (tested in this study), for effective control of the CT-Res biotype.
The relationship between different C-peptide level and insulin dose of insulin pump
Authors: Wei Yihan , Quan Li , Zhou Ting , Du Guoli , Jiang Sheng 
Published: January 2021

AbstractBackgroundThis study aims to explore the insulin requirement profiles, and analyze the related factors of type-2 diabetes mellitus (T2DM) with different C-peptide levels on insulin pump therapy.MethodsA retrospective study was conducted on 271 T2DM patients treated with insulin pumps from 2016 to 2018. These patients were divided into groups according to the ratio of C-peptide at 2 h after meals to fasting C-peptide (C2h/C0), and the dosage of insulin and influencing factors were analyzed.ResultsIn comparing group A (C2h/C0 < 2.5) with group B (C2h/C0 ≥ 2.5), the percentage of the base amount in total (%TBa, 0.50 ± 0.06) in group A was higher than that in group B (0.48 ± 0.05) (P < 0.05). Furthermore, there was a correlation between C2h/C0and waist circumference, HbA1c, Fasting Plasma Glucose (FPG) and Blood glucose 2 h after meal (2hPG) (r = −0.137, −0.154, −0.471, and −0.172; all,P < 0.05). The multiple linear regression analysis revealed that BMI and FPG were independent factors of %TBa (β′ = 0.124 and 0.144; all,P < 0.05), and BMI and FPG were independent factors of C2h/C0(β′ = −0.134 and −0.502; all,P < 0.05).ConclusionsThe basal premeal dose ratio of T2DM with different C-peptide levels differs during intensive insulin pump therapy. Parameters that indicate the glycemic control and β-cell function should be taken into consideration for total insulin requirements.
Shear-strain-mediated large nonvolatile tuning of ferromagnetic resonance by an electric field in multiferroic heterostructures
Authors: Zheng Ming , Usami Takamasa , Taniyama Tomoyasu 
Published: January 2021

AbstractControlling magnetism by an electric field is of critical importance for the future development of ultralow-power electronic and spintronic devices. Progress has been made in electrically driven nonvolatile tuning of magnetic states in multiferroic heterostructures for the information storage industry, which is exclusively attributed to the ferroelectric-polarization-switching-induced interfacial charge effect or nonlinear lattice strain effect. Here, we demonstrate that a hitherto unappreciated shear strain in the ferroelectric 0.7Pb(Mg1/3Nb2/3)O3–0.3PbTiO3 substrate triggered by an electric field can be adopted to obtain robust nonvolatile control of the ferromagnetic resonance in an elastically coupled epitaxial Fe70Rh30 thin film. The disappearance of the resonance peak in a low-field-sweeping mode and the large resonance field shift of 111 Oe upon polarization switching demonstrate a strong shear-strain-mediated magnetoelectric coupling effect. In particular, in situ Kerr measurement identifies that the nonvolatile magnetic switching purely originates from electric-field-induced 109° ferroelastic domain switching rather than from 71°/180° ferroelectric domain switching even without the assistance of a magnetic field. This discovery illustrates the role of shear strain in achieving electrically tunable nonvolatile modulation of dynamic magnetic properties, and favors the design of future energy-efficient magnetoelectric microwave devices.
Efficient phonon cascades in WSe2 monolayers
Authors: Paradisanos Ioannis , Wang Gang , Alexeev Evgeny M. , Cadore Alisson R. , Marie Xavier , Ferrari Andrea C. , Glazov Mikhail M. , Urbaszek Bernhard 
Published: January 2021

AbstractEnergy relaxation of photo-excited charge carriers is of significant fundamental interest and crucial for the performance of monolayer transition metal dichalcogenides in optoelectronics. The primary stages of carrier relaxation affect a plethora of subsequent physical mechanisms. Here we measure light scattering and emission in tungsten diselenide monolayers close to the laser excitation energy (down to ~0.6 meV). We reveal a series of periodic maxima in the hot photoluminescence intensity, stemming from energy states higher than the A-exciton state. We find a period ~15 meV for 7 peaks below (Stokes) and 5 peaks above (anti-Stokes) the laser excitation energy, with a strong temperature dependence. These are assigned to phonon cascades, whereby carriers undergo phonon-induced transitions between real states above the free-carrier gap with a probability of radiative recombination at each step. We infer that intermediate states in the conduction band at the Λ-valley of the Brillouin zone participate in the cascade process of tungsten diselenide monolayers. This provides a fundamental understanding of the first stages of carrier–phonon interaction, useful for optoelectronic applications of layered semiconductors.
CRISPR technologies and the search for the PAM-free nuclease
Authors: Collias Daphne , Beisel Chase L. 
Published: January 2021

AbstractThe ever-expanding set of CRISPR technologies and their programmable RNA-guided nucleases exhibit remarkable flexibility in DNA targeting. However, this flexibility comes with an ever-present constraint: the requirement for a protospacer adjacent motif (PAM) flanking each target. While PAMs play an essential role in self/nonself discrimination by CRISPR-Cas immune systems, this constraint has launched a far-reaching expedition for nucleases with relaxed PAM requirements. Here, we review ongoing efforts toward realizing PAM-free nucleases through natural ortholog mining and protein engineering. We also address potential consequences of fully eliminating PAM recognition and instead propose an alternative nuclease repertoire covering all possible PAM sequences.
Group-level cooperation in chimpanzees is shaped by strong social ties
Authors: Samuni Liran , Crockford Catherine , Wittig Roman M. 
Published: January 2021

AbstractHumans maintain extensive social ties of varying preferences, providing a range of opportunities for beneficial cooperative exchange that may promote collective action and our unique capacity for large-scale cooperation. Similarly, non-human animals maintain differentiated social relationships that promote dyadic cooperative exchange, but their link to cooperative collective action is little known. Here, we investigate the influence of social relationship properties on male and female chimpanzee participations in a costly form of group action, intergroup encounters. We find that intergroup encounter participation increases with a greater number of other participants as well as when participants are maternal kin or social bond partners, and that these effects are independent from one another and from the likelihood to associate with certain partners. Together, strong social relationships between kin and non-kin facilitate group-level cooperation in one of our closest living relatives, suggesting that social bonds may be integral to the evolution of cooperation in our own species.
Constraining tectonic uplift and advection from the main drainage divide of a mountain belt
Authors: He Chuanqi , Yang Ci-Jian , Turowski Jens M. , Rao Gang , Roda-Boluda Duna C. , Yuan Xiao-Ping 
Published: January 2021

AbstractOne of the most conspicuous features of a mountain belt is the main drainage divide. Divide location is influenced by a number of parameters, including tectonic uplift and horizontal advection. Thus, the topography of mountain belts can be used as an archive to extract tectonic information. Here we combine numerical landscape evolution modelling and analytical solutions to demonstrate that mountain asymmetry, determined by the location of the main drainage divide, increases with increasing uplift gradient and advection velocity. Then, we provide a conceptual framework to constrain the present or previous tectonic uplift and advection of a mountain belt from the location and migration direction of its main drainage divide. Furthermore, we apply our model to Wula Shan horst, Northeastern Sicily, and Southern Taiwan.
Nanobody-mediated control of gene expression and epigenetic memory
Authors: Van Mike V. , Fujimori Taihei , Bintu Lacramioara 
Published: January 2021

AbstractTargeting chromatin regulators to specific genomic locations for gene control is emerging as a powerful method in basic research and synthetic biology. However, many chromatin regulators are large, making them difficult to deliver and combine in mammalian cells. Here, we develop a strategy for gene control using small nanobodies that bind and recruit endogenous chromatin regulators to a gene. We show that an antiGFP nanobody can be used to simultaneously visualize GFP-tagged chromatin regulators and control gene expression, and that nanobodies against HP1 and DNMT1 can silence a reporter gene. Moreover, combining nanobodies together or with other regulators, such as DNMT3A or KRAB, can enhance silencing speed and epigenetic memory. Finally, we use the slow silencing speed and high memory of antiDNMT1 to build a signal duration timer and recorder. These results set the basis for using nanobodies against chromatin regulators for controlling gene expression and epigenetic memory.
The long noncoding RNA lncCIRBIL disrupts the nuclear translocation of Bclaf1 alleviating cardiac ischemia–reperfusion injury
Authors: Zhang Yang , Zhang Xiaofang , Cai Benzhi , Li Ying , Jiang Yuan , Fu Xiaoyu , Zhao Yue , Gao Haiyu , Yang Ying , Yang Jiming , Li Shangxuan , Wu Hao , Jin Xuexin , Xue Genlong , Yang Jiqin , Ma Wenbo , Han Qilong , Tian Tao , Li Yue , Yang Baofeng , Lu Yanjie , Pan Zhenwei 
Published: January 2021

AbstractCardiac ischemia–reperfusion (I/R) injury is a pathological process resulting in cardiomyocyte death. The present study aims to evaluate the role of the long noncoding RNA Cardiac Injury-Related Bclaf1-Inhibiting LncRNA (lncCIRBIL) on cardiac I/R injury and delineate its mechanism of action. The level of lncCIRBIL is reduced in I/R hearts. Cardiomyocyte-specific transgenic overexpression of lncCIRBIL reduces infarct area following I/R injury. Knockout of lncCIRBIL in mice exacerbates cardiac I/R injury. Qualitatively, the same results are observed in vitro. LncCIRBIL directly binds to BCL2-associated transcription factor 1 (Bclaf1), to inhibit its nuclear translocation. Cardiomyocyte-specific transgenic overexpression of Bclaf1 worsens, while partial knockout of Bclaf1 mitigates cardiac I/R injury. Meanwhile, partial knockout of Bclaf1 abrogates the detrimental effects of lncCIRBIL knockout on cardiac I/R injury. Collectively, the protective effect of lncCIRBIL on I/R injury is accomplished by inhibiting the nuclear translocation of Bclaf1. LncCIRBIL and Bclaf1 are potential therapeutic targets for ischemic cardiac disease.
A hybrid semiconducting organosilica-based O2 nanoeconomizer for on-demand synergistic photothermally boosted radiotherapy
Authors: Tang Wei , Yang Zhen , He Liangcan , Deng Liming , Fathi Parinaz , Zhu Shoujun , Li Ling , Shen Bo , Wang Zhantong , Jacobson Orit , Song Jibin , Zou Jianhua , Hu Ping , Wang Min , Mu Jing , Cheng Yaya , Ma Yuanyuan , Tang Longguang , Fan Wenpei , Chen Xiaoyuan 
Published: January 2021

AbstractThe outcome of radiotherapy is significantly restricted by tumor hypoxia. To overcome this obstacle, one prevalent solution is to increase intratumoral oxygen supply. However, its effectiveness is often limited by the high metabolic demand for O2 by cancer cells. Herein, we develop a hybrid semiconducting organosilica-based O2 nanoeconomizer pHPFON-NO/O2 to combat tumor hypoxia. Our solution is twofold: first, the pHPFON-NO/O2 interacts with the acidic tumor microenvironment to release NO for endogenous O2 conservation; second, it releases O2 in response to mild photothermal effect to enable exogenous O2 infusion. Additionally, the photothermal effect can be increased to eradicate tumor residues with radioresistant properties due to other factors. This “reducing expenditure of O2 and broadening sources” strategy significantly alleviates tumor hypoxia in multiple ways, greatly enhances the efficacy of radiotherapy both in vitro and in vivo, and demonstrates the synergy between on-demand temperature-controlled photothermal and oxygen-elevated radiotherapy for complete tumor response.
Effects of systemic inflammation on relapse in early breast cancer
Authors: McAndrew Nicholas P. , Bottalico Lisa , Mesaros Clementina , Blair Ian A. , Tsao Patricia Y. , Rosado Jennifer M. , Ganguly Tapan , Song Sarah J. , Gimotty Phyllis A. , Mao Jun J. , DeMichele Angela 
Published: January 2021

AbstractChronic inflammation has been a proposed mechanism of resistance to aromatase inhibitors in breast cancer. Stratifying by HER2 status, a matched case-control study from the Wellness After Breast Cancer-II cohort was performed to assess whether or not elevated serum inflammatory biomarkers (C-Reactive protein [CRP], interleukin-6 [IL-6], and serum amyloid A [SAA]) and/or the presence of a high-risk IL-6 promoter genotype were associated with recurrence of hormone receptor positive (HR+) early breast cancer. Estrogen levels were also measured and correlated with biomarkers and disease outcomes. CRP and SAA were significantly associated with an increased risk of recurrence in the HR+/HER2− group, but not the HR+/HER2+ group. Mean serum estrogen levels were non-significantly elevated in patients who relapsed vs. non-relapsed patients. Surprisingly, high-risk IL-6 promoter polymorphisms were strongly associated with HER2+ breast cancer relapse, which has potential therapeutic implications, as elevated intracellular IL-6 has been associated with trastuzumab resistance in pre-clinical models.
Cognitive and MRI trajectories for prediction of Alzheimer’s disease
Authors: Mofrad Samaneh A. , Lundervold Astri J. , Vik Alexandra , Lundervold Alexander S. 
Published: January 2021

AbstractThe concept of Mild Cognitive Impairment (MCI) is used to describe the early stages of Alzheimer’s disease (AD), and identification and treatment before further decline is an important clinical task. We selected longitudinal data from the ADNI database to investigate how well normal function (HC, n= 134) vs. conversion to MCI (cMCI, n= 134) and stable MCI (sMCI, n=333) vs. conversion to AD (cAD, n= 333) could be predicted from cognitive tests, and whether the predictions improve by adding information from magnetic resonance imaging (MRI) examinations. Features representing trajectories of change in the selected cognitive and MRI measures were derived from mixed effects models and used to train ensemble machine learning models to classify the pairs of subgroups based on a subset of the data set. Evaluation in an independent test set showed that the predictions for HC vs. cMCI improved substantially when MRI features were added, with an increase in $$F_1$$

F
1

-score from 60 to 77%. The $$F_1$$

F
1

-scores for sMCI vs. cAD were 77% without and 78% with inclusion of MRI features. The results are in-line with findings showing that cognitive changes tend to manifest themselves several years after the Alzheimer’s disease is well-established in the brain.