bluuebunny/crossref_metadata_2025_split huggingface dataset:
NMDAR-dependent somatic potentiation of synaptic inputs is correlated with β amyloid-mediated neuronal hyperactivity
Authors: Bao Yifei , Yang Xin , Fu Yi , Li Zhengyan , Gong Ru , Lu Wei 
Published: September 2021

Abstract
Background
β Amyloid (Aβ)-mediated neuronal hyperactivity, a key feature of the early stage of Alzheimer’s disease (AD), is recently proposed to be initiated by the suppression of glutamate reuptake. Nevertheless, the underlying mechanism by which the impaired glutamate reuptake causes neuronal hyperactivity remains unclear. Chronic suppression of the glutamate reuptake causes accumulation of ambient glutamate that could diffuse from synaptic sites at the dendrites to the soma to elevate the tonic activation of somatic N-methyl-D-aspartate receptors (NMDARs). However, less attention has been paid to the potential role of tonic activity change in extrasynaptic glutamate receptors (GluRs) located at the neuronal soma on generation of neuronal hyperactivity.

Methods
Whole-cell patch-clamp recordings were performed on CA1 pyramidal neurons in acute hippocampal slices exposed to TFB-threo-β-benzyloxyaspartic acid (TBOA) or human Aβ1–42 peptide oligomer. A series of dendritic patch-clamp recordings were made at different distances from the soma to identify the location of the changes in synaptic inputs. Moreover, single-channel recording in the cell-attached mode was performed to investigate the activity changes of single NMDARs at the soma.

Results
Blocking glutamate uptake with either TBOA or the human Aβ1–42 peptide oligomer elicited potentiation of synaptic inputs in CA1 hippocampal neurons. Strikingly, this potentiation specifically occurred at the soma, depending on the activation of somatic GluN2B-containing NMDARs (GluN2B-NMDARs) and accompanied by a substantial and persistent increment in the open probability of somatic NMDARs. Blocking the activity of GluN2B-NMDARs at the soma completely reversed both the TBOA-induced or the Aβ1–42-induced somatic potentiation and neuronal hyperactivity.

Conclusions
The somatic potentiation of synaptic inputs may represent a novel amplification mechanism that elevates cell excitability and thus contributes to neuronal hyperactivity initiated by impaired glutamate reuptake in AD.
The circular RNA circCPE regulates myoblast development by sponging miR-138
Authors: Ru Wenxiu , Qi Ao , Shen Xuemei , Yue Binglin , Zhang Xiaoyan , Wang Jian , Cao Hui , Chen Hong 
Published: September 2021

Abstract
Background
Skeletal muscle development, a long-term and complex process, is controlled by a set of the myogenic genes. Circular RNAs (circRNAs), a class of noncoding RNA, have been shown to regulate various biological processes. Recent studies indicate circRNAs may be involved in myogenesis, but the role and regulatory mechanism of circRNAs in myogenesis is largely unknown. In the present study, circCPE was firstly found to promote the bovine myoblast proliferation and inhibit cell apoptosis and differentiation by influencing the expression of FOXC1 in a miR138-mediated manner. And in vivo experiments revealed that overexpression of circCPE attenuates skeletal muscle regeneration.

Results
We identified a novel circular RNA circCPE by analyzing circRNAs sequencing data of bovine muscle tissue. Sequencing verification, RNase R treatment and Actinomycin D treatment confirmed the circular nature of circCPE in bovine muscle. Functional assays showed that overexpression of circCPE could inhibit bovine myoblast apoptosis and differentiation, as well as facilitate cell proliferation. Moreover, in vivo experiments revealed that overexpression of circCPE attenuates skeletal muscle regeneration. In consideration of circRNA action as miRNAs sponge, we found that circCPE harbors miR-138 binding sites and absorbed miR-138. Mechanistically, the rescue experiments showed that the overexpression of circCPE can counteract the inhibitory effect of miR-138 on the cell proliferation and the accelerated effects on the differentiation and apoptosis. Subsequently, we found that circCPE sequester the inhibitory effect of miR-138 on FOXC1 so as to involve in myogenesis.

Conclusions
Collectively, we constructed a novel circCPE/miR-138/FOXC1 regulatory network in bovine myogenesis, which further provide stronger evidence that circRNA involved in muscle development acting as miRNA sponge.
An artificial intelligence approach to monitor student performance and devise preventive measures
Authors: Khan Ijaz , Ahmad Abdul Rahim , Jabeur Nafaa , Mahdi Mohammed Najah 
Published: September 2021

AbstractA major problem an instructor experiences is the systematic monitoring of students’ academic progress in a course. The moment the students, with unsatisfactory academic progress, are identified the instructor can take measures to offer additional support to the struggling students. The fact is that the modern-day educational institutes tend to collect enormous amount of data concerning their students from various sources, however, the institutes are craving novel procedures to utilize the data to magnify their prestige and improve the education quality. This research evaluates the effectiveness of machine learning algorithms to monitor students’ academic progress and informs the instructor about the students at the risk of ending up with unsatisfactory result in a course. In addition, the prediction model is transformed into a clear shape to make it easy for the instructor to prepare the necessary precautionary procedures. We developed a set of prediction models with distinct machine learning algorithms. Decision tree triumph over other models and thus is further transformed into easily explicable format. The final output of the research turns into a set of supportive measures to carefully monitor students’ performance from the very start of the course and a set of preventive measures to offer additional attention to the struggling students.
Reduced turnover rate of topsoil organic carbon in old-growth forests: a case study in subtropical China
Authors: Xiong Xin , Liu Juxiu , Zhou Guoyi , Deng Qi , Zhang Huiling , Chu Guowei , Meng Ze , Zhang Deqiang 
Published: September 2021

Abstract
Background
Old-growth forests are irreplaceable with respect to climate change mitigation and have considerable carbon (C) sink potential in soils. However, the relationship between the soil organic carbon (SOC) turnover rate and forest development is poorly understood, which hinders our ability to assess the C sequestration capacity of soil in old-growth forests.

Methods
In this study, we evaluated the SOC turnover rate by calculating the isotopic enrichment factor β (defined as the slope of the regression between 13C natural abundance and log-transformed C concentrations) along 0–30 cm soil profiles in three successional forests in subtropical China. A lower β (steeper slope) is associated with a higher turnover rate. The three forests were a 60-year-old P. massoniana forest (PF), a 100-year-old coniferous and broadleaved mixed forest (MF), and a 400-year-old monsoon evergreen broadleaved forest (BF). We also analyzed the soil physicochemical properties in these forests to examine the dynamics of SOC turnover during forest succession and the main regulators.

Results
The β value for the upper 30-cm soils in the BF was significantly (p < 0.05) higher than that in the PF, in addition to the SOC stock, although there were nonsignificant differences between the BF and MF. The β value was significantly (p < 0.05) positively correlated with the soil recalcitrance index, total nitrogen, and available nitrogen contents but was significantly (p < 0.01) negatively correlated with soil pH.

Conclusions
Our results demonstrate that SOC has lower turnover rates in old-growth forests, accompanied by higher soil chemical recalcitrance, nitrogen status, and lower soil pH. This finding helps to elucidate the mechanism underlying C sequestration in old-growth forest soils, and emphasizes the important value of old-growth forests among global C sinks.
Laterally rotated flap for soft tissue augmentation around maxillary loaded osseointegrated dental implants: preliminary results of a pilot study
Authors: Moreno Rodríguez Jose A. , Guerrero Gironés Julia , Pecci Lloret Miguel R. , Ortiz Ruiz Antonio J. 
Published: September 2021

AbstractA minimal width and thickness of keratinized and attached soft tissue is desirable to prevent peri-implant diseases. This report describes the preliminary results of a pilot study of a surgical approach for soft tissue augmentation around loaded dental implants in the partially or totally edentulous maxilla. Four patients presenting eight maxillary implants with a buccal peri-implant soft tissue deficiency received a laterally rotated flap. A buccal mesial and apical recipient area was created around each implant, and a pediculated keratinized graft was rotated 90° from the distopalatal and positioned and sutured on the peri-implant buccal aspect. All implants treated showed a gain in buccal clinical peri-implant attachment (1.37 ± 0.44 mm) and buccal soft tissue levels (2.06 ± 1.40 mm) and interproximal soft tissue levels (1 ± 0.75 mm). The technique provided quality soft tissue with a gain in soft tissue thickness (3.06 ± 0.68 mm) and keratinized wide tissue (4.69 ± 0.80 mm) with minimal morbidity (1575 ± 549.67 mg of ibuprofen) and maintenance of prosthetic loading. Peri-implant soft tissue stability was maintained for 13.5 ± 1.87 months. Laterally rotated flap can be applied and provide clinical benefits to compromised implants due to the presence of buccal peri-implant soft tissue deficiency. Further studies are required to confirm these preliminary results.
Accessory breast cancer in the inframammary region: a case report and review of the literature
Authors: Eguchi Yuka , Yoshinaka Heiji , Hayashi Naoki , Sueyoshi Kazunobu , Uchikura Keiichiro , Nomoto Yuki , Nagata Ayako , Saho Hazuki , Shinden Yoshiaki , Ohtsuka Takao 
Published: September 2021

Abstract
Background
Although a few cases of accessory breast cancer (ABC) have been reported, most were in the axillary region. We encountered an extremely rare case of ABC in the inframammary region (IMR).

Case presentation
The patient was a 68-year-old postmenopausal woman who had noticed a congenital accessory nipple in her left IMR with slight, occasional discharge 20 years ago. Recently, she noticed a mass under the accessory nipple and visited a nearby clinic; fine-needle aspiration cytology of the mass revealed that it was malignant. She presented to our department 2 weeks after she had noticed the mass. Physical and imaging examinations showed an irregular tumor mass 1.7 × 1.4 × 1.0 cm in size connected to the accessory nipple beneath the left normal breast. Neither distant metastasis nor lymph node swelling was observed. Ultrasound-guided core needle biopsy revealed the mass to be invasive ductal carcinoma. We diagnosed her tumor as ABC in the left IMR; cT1cN0M0: stage IA. Curative wide resection with sentinel node biopsy was performed. Intraoperative evaluation of the frozen section revealed a hot and green ipsilateral axillary lymph node that was free from carcinoma; therefore, nodal dissection was avoided. Histopathological examination including immunochemical staining revealed that the tumor was invasive ductal carcinoma arising from the accessory breast tissue, scirrhous type, 1.7 × 1.4 × 1.0 cm in size, with a solid intraductal component. There was no lymphovascular infiltration, and the surgical margin was 1.5 cm or more. The tumor was estrogen and progesterone receptor-positive, Her2/neu-negative, and had a Ki-67 labeling index of 20%. There was no involvement of the three hot and/or green nodes. The final classification was pT1cN0(sn)M0: stage IA. Letrozole 2.5 mg/day will be administered for 5 years as adjuvant hormonal therapy.

Conclusions
A cutaneous and/or subcutaneous lesion except for proper breast tissue on the milk line, or mammary ridge from axilla to groin may be an accessory breast tissue. Its serial abnormalities must be worried malignant potential to ductal carcinoma which needs some imaging and pathological examinations for definitive diagnosis and appropriate treatment according to the usual orthotopic breast cancer without delay.
Lottery-like preferences and the MAX effect in the cryptocurrency market
Authors: Ozdamar Melisa , Akdeniz Levent , Sensoy Ahmet 
Published: September 2021

AbstractWe investigate the significance of extreme positive returns in the cross-sectional pricing of cryptocurrencies. Through portfolio-level analyses and weekly cross-sectional regressions on all cryptocurrencies in our sample period, we provide evidence for a positive and statistically significant relationship between the maximum daily return within the previous month (MAX) and the expected returns on cryptocurrencies. In particular, the univariate portfolio analysis shows that weekly average raw and risk-adjusted return differences between portfolios of cryptocurrencies with the highest and lowest MAX deciles are 3.03% and 1.99%, respectively. The results are robust with respect to the differences in size, price, momentum, short-term reversal, liquidity, volatility, skewness, and investor sentiment.
Development of an online suicide prevention program involving people with lived experience: ideas and challenges
Authors: Dreier Mareike , Baumgardt Johanna , Bock Thomas , Härter Martin ,   The 8 Lives Team, Liebherz Sarah 
Published: September 2021

Abstract
Background
Fear of stigmatization, self-stigmatization, and insufficient information can lead to secrecy, reduced help-seeking, lower self-esteem, and lower self-efficacy among people affected by suicidality or suicide. Therefore, we developed an online suicide prevention program aiming to improve knowledge about suicidality and suicide stigma.

Methods
Inspired by the Australian program The Ripple Effect, a German team comprising people with lived experience of suicide, researchers, and clinicians was established for developing an online suicide prevention program. Therefore, we oriented on guidelines for evidence-based health information, for reporting on suicide, and on dealing with suicidality. The lived experience team discussed and developed concept, structure, and content of the program. This manuscript presents summaries of protocols from 16 team meetings and 3 written text reviews to outline the program development process. A summative evaluation 3 years after program development began was qualitatively analyzed based on thematic analysis.

Results
Between 2018 und 2021, the lived experience team (n = 10) discussed possibilities of support in suicidal crises, attitudes towards suicide, content, and design of the online program. In a structured process, six members of the lived experience team reviewed the content. Eight persons shared their lived experience of suicide in video reports by focusing on constructive ways of dealing with suicidality or a loss by suicide, conveying hope and encouraging people to continue living. Team members recommended greater public and patient involvement from the application stage, as well as more financial and personnel resources.

Conclusions
Through contributions to discussions and text reviews, the lived experience team shaped decisions in the program development process. While involving persons with lived experiences of suicide, it is important to consider that suicidality is 1. emotionally challenging, 2. a stigmatized issue, and 3. that the aspect of safety must be a priority. A distinction must be made between the duty of care based on actual risk and inappropriate overprotection. Hereby, transparency, autonomy, and a clear structure appeared to be helpful. For further research, we recommend a structured formative review process of the development of the program. Additionally, we recommend discussing the purpose and the specific design of the evaluation with a lived experience team in advance.
Trial registration German Clinical Trial RegisterDRKS00015071 on August 6, 2018.
Only two subscales of the Coping Strategies Questionnaire are culturally relevant for people with chronic low back pain in Nigerian Igbo populations: a cross-cultural adaptation and validation study
Authors: Igwesi-Chidobe Chinonso Nwamaka , Sorinola Isaac Olubunmi , Godfrey Emma Louise 
Published: September 2021

Abstract
Background
Pain coping strategies are important in the chronicity of low back pain and the associated disability. However, their exact influence is unknown in many African contexts such as rural Nigeria due to lack of outcome instruments with which to measure them. This study aimed to cross-culturally adapt and psychometrically test the Coping Strategies Questionnaire (CSQ) in Igbo populations in Nigeria.

Methods
The CSQ was forward and back translated by clinical and non-clinical translators; evaluated by an expert review committee. The translated measure was piloted amongst twelve rural Nigerian dwellers with chronic low back pain (CLBP) using the think-aloud cognitive interviewing style. Internal consistency (Cronbach’s alpha), test–retest reliability (intra-class correlation coefficient—ICC and Bland–Altman plot), and minimal detectable change were examined amongst 50 people with CLBP in rural and urban Nigerian populations. Construct validity was determined by assessing the correlations between the adapted CSQ and measures of disability, pain intensity, fear avoidance beliefs, and illness perceptions using Spearman’s correlation analyses with 200 adults with CLBP in rural Nigeria. Exploratory factor analyses using Kaiser criterion (eigenvalue) and parallel analysis as methods for determining dimensionality were conducted with the same sample.

Results
Fourteen out of 42 items were routinely adopted in this population including all items of catastrophising subscale, and all but one item of praying and hoping subscale. Catastrophising and praying and hoping subscales had the highest Cronbach’s alpha. All subscales had high ICCs with Bland–Altman plots that showed good agreement. All coping strategies were positively correlated with self-reported disability and pain intensity with catastrophising subscale having the highest values. Seven-factor and three-factor structures were produced with the Kaiser criterion and parallel analysis, with different items from the original CSQ, except for catastrophising.

Conclusions
Catastrophising and praying and hoping may be the relevant coping strategies in this population. More culturally relevant measures of pain coping strategies that include adaptive coping strategies may need to be developed for African contexts such as rural Nigeria.
A comparative review on heart ion channels, action potentials and electrocardiogram in rodents and human: extrapolation of experimental insights to clinic
Authors: Joukar Siyavash 
Published: September 2021

AbstractElectrocardiogram (ECG) is a non-invasive valuable diagnostic tool that is used in clinics for investigation and monitoring of heart electrical rhythm/conduction, ischemia/injury of heart, electrolyte disturbances and agents/drugs induced cardiac toxicity. Nowadays using animal models to study heart diseases such as electrical and mechanical disturbance is common. In addition, given to ethical consideration and availability, the use of small rodents has been a top priority for cardiovascular researchers. However, extrapolation of experimental findings from the lab to the clinic needs sufficient basic knowledge of similarities and differences between heart action potential and ECG of rodents and humans in normal and disease conditions. This review compares types of human action potentials, the dominant ion currents during action potential phases, alteration in ion channels activities in channelopathies-induced arrhythmias and the ECG appearance of mouse, rat, guinea pig, rabbit and human. Also, it briefly discusses the responsiveness and alterations in ECG following some interventions such as cardiac injury and arrhythmia induction. Overall, it provides a roadmap for researchers in selecting the best animal model/species whose studies results can be translated into clinical practice. In addition, this study will also be useful to biologists, physiologists, pharmacologists, veterinarians and physicians working in the fields of comparative physiology, pharmacology, toxicology and diseases.
Micro-morphologies of SBS modifier at mortar transition zone in asphalt mixture with thin sections and fluorescence analysis
Authors: Xiao Yue , Yunusa Mujaheed , Yan Boxiang , Zhang Xiaoshan , Chang Xiwen 
Published: September 2021

AbstractThe microstructure control of modified asphalt, especially the micro-dispersion of the SBS modifier in the mortar transition zone, is a critical technology for the performance design of modified asphalt. To characterize the micro-dispersive morphology of SBS modifiers, thin-section preparation techniques that can be used to analyze the original microstructure of the asphalt mixture were proposed and introduced in this study. Flexible resin is filled into the mixture at vacuum conditions to ensure accepted sample conditions for preparing thin sections of asphalt mixture. The morphology parameters, including SBS area ratio, box dimension, SBS average particle area and its coefficient of variation, area-weighted average axis ratio, and coefficient of variation, were plotted from fluorescence images to characterize the micro-morphological distribution of the SBS modifier in detail. Results have shown that the area ratio increased with the increase in SBS content, while the box dimension was reduced and the distribution uniformity of the particles decreased. The superfluous SBS modifier in the binder at a too high adding ratio will decrease the value of the box dimension. Lower modification temperature worsened the SBS modifier in the mixture, resulting in a wide range of particle size, higher axis ratio, and higher area ratio. The micro-morphologies of SBS in the asphalt mixture phase varied a lot from the asphalt binder phase. The additional materials of mineral filler and fine aggregate, together with the other heating processes, will significantly influence the swelling state and particle size of the SBS modifier.
The impact of COVID-19 pandemic on Islamic versus conventional stock markets: international evidence from financial markets
Authors: Nomran Naji Mansour , Haron Razali 
Published: September 2021

AbstractThis study employs samplet-tests and panel pooled OLS regression to investigate the impact of COVID-19 pandemic on Islamic versus conventional stock markets returns. The study uses daily data from 15 countries over the period of September 01, 2019–April 30, 2020, which covers two main periods and over four sub-periods. Findings reveal that the returns of Islamic indices begun to be positive instead of negative by mid-April 2020, while returns of conventional ones remain negative throughout the periods. Furthermore, the results suggest a negative and statistically significant impact of COVID-19 on the performance of both stock indices. Nevertheless, this impact is weak on the Islamic indices and strong on the conventional ones. Overall, the findings indicate that Islamic stock markets perform better before and during COVID-19 than the conventional ones, and the adverse impact of the pandemic on the stock markets is relatively lesser for the Islamic indices.
Joule-Thomson expansion for noncommutative uncharged black holes
Authors: Morais Graça J. P. , Capossoli Eduardo Folco , Boschi-Filho Henrique 
Published: September 2021

Abstract
In this work we study the Joule-Thomson expansion for uncharged black holes in a noncommutative scenario characterized by a parameter θ, which is present in the horizon function. We calculate the inversion temperature for some values of θ and the isenthalpics for fixed masses. We find that the uncharged noncommutative black hole behaves as a charged commutative one.