bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward an integrated system of climate change and human health indicators: a conceptual framework
Authors: Liu Ann Y. , Trtanj Juli M. , Lipp Erin K. , Balbus John M. 
Published: June 2021

AbstractEnvironmental health indicators are helpful for tracking and communicating complex health trends, informing science and policy decisions, and evaluating public health actions. When provided on a national scale, they can help inform the general public, policymakers, and public health professionals about important trends in exposures and how well public health systems are preventing those exposures from causing adverse health outcomes. There is a growing need to understand national trends in exposures and health outcomes associated with climate change and the effectiveness of climate adaptation strategies for health. To date, most indicators for health implications of climate change have been designed as independent, individual metrics. This approach fails to take into account how exposure-outcome pathways for climate-attributable health outcomes involve multiple, interconnected components. We propose reframing climate change and health indicators as a linked system of indicators, which can be described as follows: upstream climate drivers affect environmental states, which then determine human exposures, which ultimately lead to health outcomes; these climate-related risks are modified by population vulnerabilities and adaptation strategies. We apply this new conceptual framework to three illustrative climate-sensitive health outcomes and associated exposure-outcome pathways: pollen allergies and asthma, West Nile virus infection, and vibriosis.
On the Difficulty of Budget Allocation in Claims Problems with Indivisible Items and Prices
Authors: Estañ Teresa , Llorca Natividad , Martínez Ricardo , Sánchez-Soriano Joaquín 
Published: June 2021

AbstractIn this paper we study the class of claims problems where the amount to be divided is perfectly divisible and claims are made on indivisible units of several items. Each item has a price, and the available amount falls short to be able to cover all the claims at the given prices. We propose several properties that may be of interest in this particular framework. These properties represent the common principles of fairness, efficiency, and non-manipulability by merging or splitting. Efficiency is our focal principle, which is formalized by means of two axioms: non-wastefulness and Pareto efficiency. We show that some combinations of the properties we consider are compatible, others are not.
Is it Possible to Assess the Two-Domain Definition of the Broad Autism Phenotype Using the Available Measurement Tools?
Authors: Godoy-Giménez M. , González-Rodríguez A. , Cañadas F. , Estévez A. F. , Sayans-Jiménez P. 
Published: June 2021

AbstractAlthough, the operationalization of the autism spectrum disorder has been updated around two domains, the broad autism phenotype (BAP) one has not. Additionally, the items of the three common BAP measures, the Broad Autism Phenotype Questionnaire (BAPQ), the Autism Quotient, and the Social Responsiveness Scale (SRS), remain organized around a non-consensual number of factors. We explored whether the items of these measures matched with the two-domain operationalization through a parallel analysis, which has suggested two main components, and two expert judgments which have assessed item wording, relevance, and construct representativeness. A remaining pool of 48 BAP-relevant items suggested a possible under-representation of two subdomains. Despite the relevance of all the BAPQ items, only the SRS ones tapped in all subdomains.
The evolution of language ideological debates about English and French in a multilingual humanitarian organisation
Authors: Garrido Maria Rosa 
Published: June 2021

AbstractThis article traces the evolution of the ideological construction of elite multilingualism, with a focus on the values accorded to French and English, under transforming socioeconomic and institutional conditions at the International Committee of the Red Cross (ICRC). The ICRC, a major humanitarian agency based in Geneva, opens a window onto the construction of “internationalisation” and its accompanying language ideologies, resulting in fluctuating hiring requirements for “delegates” (expatriate representatives). The data include job advertisements for delegate posts from 1989 to 2020 complemented by interviews with different generations of delegates and ethnographic fieldwork in a recruitment fair. The analysis of language ideological debates at the ICRC illuminates the articulations and tensions between “roots” in Geneva, symbolised by French, and “routes” in its delegations worldwide, with English as a lingua franca, in dominant discourses about multilingualism. The requirements for ICRC delegates include English as a must and at least a second ICRC working language. Concerning the latter, there are tensions between the desired language regime at headquarters, privileging French as the “parent” language, and the current needs in key operations, with a shortage of Arabic speakers. The analysis shows that French requirements for generalist delegates have fluctuated from perfect command and good knowledge to an optional second working language. In the 2020 recruitment campaign, elite multilingualism is hierarchically stratified into English as a global language, other “working languages” including Arabic, and non-European languages such as Pashto or Dari as newly-introduced “assets”.
Does positive MGMT methylation outbalance the limitation of subtotal resection in glioblastoma IDH-wildtype patients?
Authors: Mareike Müller , Franziska Staub-Bartelt , Julia Ehrmann , Daniel Hänggi , Michael Sabel , Jörg Felsberg , Marion Rapp 
Published: June 2021

Abstract
Background
The impact on survival of complete resection (CR) in patients with malignant glioma and MGMT promoter methylation on adjuvant therapy strategies has been proven in the past. However, it is not known whether a MGMT promoter methylation can compensate a subtotal resection. Therefore, we analyzed the progress of postoperative residual tumor tissue depending on the molecular tumor status.

Methods
We included all glioblastoma, IDH-wildtype (WHO grade IV) patients with postoperative residual tumor tissue, who were treated at our neurooncological department between 2010 and 2018. Correlation of molecular patterns with clinical data and survival times was performed. The results were compared to patients following CR.

Results
267 patients with glioblastoma, IDH-wildtype (WHO grade IV) received surgery of whom 81 patients with residual tumor were included in the analysis. MGMT promoter was methylated in 31 patients (38.27%). Median OS and PFS were significantly increased in patients with methylated MGMT promoter (mOS: 16 M vs. 13 M, p = 0.009; mPFS: 13 M vs. 5 M, p = 0.003). In comparison to survival of patients following CR, OS was decreased in patients with residual tumor regardless MGMT methylation.

Conclusion
Our data confirm impact of MGMT promoter methylation in patients with glioblastoma, IDH-wildtype on OS and PFS. However, in comparison to patients after CR, a methylated MGMT promoter cannot compensate the disadvantage due to residual tumor volume. In terms of personalized medicine and quality of life as major goal in oncology, neuro-oncologists have to thoroughly discuss advantages and disadvantages of residual tumor volume versus possible neurological deficits in CR.
Biofilms in the gravity sewer interfaces: making a friend from a foe
Authors: Augustyniak Adrian , Sikora Pawel , Grygorcewicz Bartłomiej , Despot Daneish , Braun Burga , Rakoczy Rafał , Szewzyk Ulrich , Barjenbruch Matthias , Stephan Dietmar 
Published: June 2021

AbstractSewer systems are an integral part of our modern civilization and are an imperative underground infrastructure asset that our society relies on. In Western Europe alone, 92% of the resident pollution is connected to sewer systems. This extensive coverage of sewerage systems presents an ideal habitation for microorganisms to strive. Sewers can be considered continuous flow bioreactors. They are always colonized by bacteria, either in a planktonic state traveling along the pipe with the water flow or dragged in sediment, or organized as biofilms. Many studies have been devoted to the detrimental effects of microorganisms on sewer systems made of concrete. However, their metabolic activity can also be beneficial, lead to more effective wastewater treatment, or be beneficial for concrete pipes. This aspect has not been thoroughly studied to date and requires further investigation. Therefore, in this Review, we highlighted the positive and negative activity of biofilms and their participation in five proposed mass exchange points in gravity sewers. Furthermore, we systematized and reviewed state of the art regarding methods that could be potentially used to remove or engineer these biological structures to increase the sustainability of sewers and achieve a better pre-treatment of wastewater. We have also indicated research gaps that could be followed in future studies.
Antioxidant and polyphenol content of different Vitis vinifera seed cultivars and two facilities of production of a functional bakery product
Authors: Kapcsándi Viktória , Hanczné Lakatos Erika , Sik Beatrix , Linka László Ádám , Székelyhidi Rita 
Published: June 2021

AbstractThis study aimed to examine the differences between the antioxidant capacity, and the total polyphenol content of the seed of eight different grape varieties. We also attempt to create a functional loaf enriched with grape seed meal. To achieve this goal, 3, 6, and 9% of the grape seed meal were added to the loaves made of bread flour and gluten-free flour mixture, and then the changes in their antioxidant and polyphenol content were examined. Based on the results, there were significant differences between the polyphenol and antioxidant content of grape seed varieties. The antioxidant content of the grape seeds varied between 228.50 mg AAE/g (94.80 mg TE/g) and 438.33 mg AAE/g (181.86 mg TE/g) in case of fatty samples, and between 176.29 mg AAE/g (41.24 mg TE/g) and 424.91 mg AAE/g (99.40 mg TE/g) in case of defatted samples. The total polyphenol content of the fatty samples changed between 91.16 and 221.81 mg GAE/g; in case of defatted samples, it ranged from 46.01 to 207.68 mg GAE/g. Rhine Riesling contained the greatest amount of these compounds. The functionality of loafs was confirmed by spectrophotometric analysis. Total polyphenol content ranged from 0.91 to 3.16 mg GAE/g in case of wheat loafs, and from 1.39 to 5.92 mg GAE/g in case of gluten-free loafs, while the total antioxidant content changed between 0.70 and 6.44 mg AAE/g in case of wheat loafs, and ranged from 2.55 to 9.75 in case of gluten-free loafs.
Graphic abstract
Diagnostic yield of small bowel capsule endoscopy in obscure gastrointestinal bleeding: a real-world prospective study
Authors: Romeo Samanta , Neri Benedetto , Mossa Michelangela , Riccioni Maria Elena , Scucchi Ludovica , Sena Giorgia , Potenza Saverio , Petruzziello Carmelina , Biancone Livia 
Published: June 2021

AbstractSmall bowel capsule endoscopy (SBCE) visualizes the small bowel (SB) mucosa. Gastrointestinal (GI) bleeding from SB accounts for the majority of SBCE indications. We aimed to assess, in a “real-world” prospective study, the diagnostic yield of SBCE in a cohort of consecutive patients with obscure gastrointestinal bleeding (OGIB). Secondary end point was to assess the frequency of adverse events and the role of SBCE in determining the diagnostic work-up and clinical outcome. From 2016 to 2018, all patients referred for SBCE examination were enrolled. Indication for SBCE was re-assessed by 2 dedicated gastroenterologists. Inclusion criteria: (1) age ≥ 18 and ≤ 85 years; (2) diagnosis of OGIB; 3) non-diagnostic standard bidirectional endoscopy; (4) informed consent. Exclusion criteria: (1) deglutition impairment; (2) SBCE contraindications; (3) pregnancy. The cohort included 50 patients [males 18 (36%), age 68 (27–83)]. SBCE indication: patients with ongoing overt OGIB (Group A) (n = 11; 22%), previous overt OGIB (Group B) (n = 14; 28%), occult bleeding (with Iron Deficiency Anaemia) (Group C) (n = 25; 50%). SBCE detected clinically relevant lesions in 46 (92%) cases. Clinically relevant lesions were more frequent in Group C (24/25; 96%), followed by Group A (10/11; 91%) and Group B (12/14; 85.5%). After SBCE, treatment was medical (60%); endoscopic (14%), surgical (36%) or conservative (18%). Clinical follow-up showed complete resolution in 63.2%, partial/absent resolution in 18.4% of cases. In a prospective study, the high diagnostic yield of SBCE supports its role as first-line investigation in patients with OGIB. However, this achievement requires an accurate and timely assessment by dedicated gastroenterologists.
Improved indocyanine green retention after short-term lenvatinib withdrawal in three patients with hepatocellular carcinoma
Authors: Sugimoto Rie , Inada Hiroki , Tanaka Yuki , Senju Takeshi , Aratake Yoshifusa , Nakanishi Akira , Miki Masami , Lee Lingaku , Hisano Terumasa , Matsumoto Yoshihiro , Mano Yohei , Iguchi Tomohiro , Sugimachi Keishi , Okumura Yukihiko , Taguchi Kenichi , Furukawa Masayuki 
Published: June 2021

AbstractUse of lenvatinib, which has a high response rate in advanced hepatocellular carcinoma, sometimes results in tumor shrinkage and resectability of previously unresectable liver cancers. In Asia, including Japan, liver reserve, one of the determinants of resectability, is mainly determined by the indocyanine green (ICG) retention rate. Three patients with advanced liver cancer treated at our institution had very poor ICG retention rates during treatment with lenvatinib. Lenvatinib may reduce blood flow in both cancerous and non-cancerous regions by inhibiting vascular endothelial growth factor. Therefore, accurate determination of liver function likely requires withdrawal of this treatment several days before ICG retention testing.
Multidrug-resistant Acinetobacter baumannii infections in COVID-19 patients hospitalized in intensive care unit
Authors: Russo Alessandro , Gavaruzzi Francesca , Ceccarelli Giancarlo , Borrazzo Cristian , Oliva Alessandra , Alessandri Francesco , Magnanimi Eugenia , Pugliese Francesco , Venditti Mario 
Published: June 2021

Abstract
Objectives
Superinfections in patients hospitalized in intensive care unit (ICU) are an important and challenging complication, also in COVID-19. However, no definitive data are available about the role of multidrug-resistant Acinetobacter baumannii (MDR-AB) in COVID-19.

Methods
This was a single-center, cross-sectional study including patients with MDR-AB infections admitted to ICU with or without COVID-19, between January 2019 and January 2021. The primary objective of the study was to evaluate risk factor for MDR-AB infections in ICU patients hospitalized for COVID-19 or other etiology. The secondary endpoints were 30-days mortality in all study population and risk factors associated with development of bloodstream infection (BSI).

Results
During the study period 32 adults with COVID-19 were enrolled and compared with 115 patients admitted in the same ICU for other reasons. We observed a total of 114 deaths, with a survival rate of 29.3%: 18.8% in COVID-19 and 32.2% in control group. Relative risk for MDR-AB infection in COVID-19 showed that serum lactate levels mmol/l > 2, Acinetobacter baumannii colonization, BSI and steroid therapy were observed more frequently in COVID-19 patients. Cox regression analysis showed that serum lactate levels > 2 mmol/l, Acinetobacter baumannii colonization, BSI, and steroid therapy were associated with 30-days mortality. Finally, patients with COVID-19, white blood cells count > 11,000 mm3, serum lactate levels > 2 mmol/l, infections at time of ICU admission, Acinetobacter baumannii colonization, and steroid therapy were independently associated with development of BSI.

Conclusions
Our data highlight the impact of BSI on outcome, the role of Acinetobacter baumannii colonization and the use of steroids on the risk to develop MDR-AB infections also during COVID-19.
Consumption of Mineral Fertilizers in the Polish Agriculture – Trends and Directions of Changes
Authors: Piwowar Arkadiusz 
Published: June 2021

AbstractBalanced, rational fertilization determines high and valuable yields of crops. Polish agriculture has been considered traditional, pro-ecological, with relatively low consumption of agrochemicals for many decades. Transformations in the economic and social area, in particular Poland’s accession to the European Union, have significantly changed this picture. This paper presents the results of the research on the trends in fertilizer consumption in the Polish agriculture. The main time range of the analyses covered the period of 2013–2017. The source materials used in the study were statistical data for the entire country and provinces, published by the Central Statistical Office (GUS), as well as results of empirical studies. According to analyses, the pressure associated with the increase in the use of mineral fertilizers in Poland is growing. In the economic year 2017/2018, the average consumption of mineral fertilizers in Poland was at a level of 141.6 kg NPK per hectare of agricultural lands and was higher by 39.2 kg than in the 2004/2005 season. The empirical studies were carried out in six randomly selected provinces in Poland. Total 1034 surveys completed by farmers were analysed. Comparative analyses were carried out using a multiple correspondence analysis (MPA). Based on the analysis performed, it can be stated that the direction of changes in the consumption of fertilizers depends on the area and economic size of the agricultural holding as well as on the district in which the agricultural holding is located. The article points out problems in the area of sustainable fertilizer consumption in Poland (high consumption of nitrogen fertilizers, low level of soil liming, etc.). Perspective directions of changes (precision agriculture, innovative fertilizers, increased farmers’ awareness of nutrient efficiency and reduction of negative impact on the environment) were also summarized.
A cooperative coevolution algorithm for complex hybrid seru-system scheduling optimization
Authors: Wu Yuting , Wang Ling , Chen Jing-fang 
Published: June 2021

AbstractUnder the current volatile business environment, the requirement of flexible production is becoming increasingly urgent. As an innovative production mode, seru-system with reconfigurability can overcome the lack of flexibility in traditional flow lines. Compared with pure seru-system, the hybrid seru-system composed of both serus and production lines is more practical for adapting to many production processes. This paper addresses a specific hybrid seru-system scheduling optimization problem (HSSOP), which includes three strongly coupled sub-problems, i.e., hybrid seru formation, seru scheduling and flow line scheduling. To minimize the makespan of the whole hybrid seru-system, we propose an efficient cooperative coevolution algorithm (CCA). To tackle three sub-problems, specific sub-algorithms are designed based on the characteristic of each sub-problem, i.e., a sub-space exploitation algorithm for hybrid seru formation, an estimation of distribution algorithm for seru scheduling, and a first-arrive-first-process heuristic for flow line scheduling. Since three sub-problems are coupled, a cooperation coevolution mechanism is proposed for the integrated algorithm by information sharing. Moreover, a batch reassign rule is designed to overcome the mismatch of partial solutions during cooperative coevolution. To enhance the exploitation ability, problem-specific local search methods are designed and embedded in the CCA. In addition to the investigation about the effect of parameter setting, extensive computational tests and comparisons are carried out which demonstrate the effectiveness and efficiency of the CCA in solving the HSSOP.
Exploring technology opportunities and evolution of IoT-related logistics services with text mining
Authors: Chen Mu-Chen , Ho Pui Hung 
Published: June 2021

AbstractMany IoT technologies have been applied in the logistics industry in recent years, and they have had a substantial impact on many sectors such as shipping, air freight, warehousing, inventory, etc. Exploring technology opportunities and carrying out technological trend analysis are essential for IoT’s evolution, and there are many techniques or methods for doing so. In this paper, data analysis and text mining techniques, technology opportunity analysis (TOA) and technology-service evolution analysis (TSEA) have been applied to analyze and observe IoT technologies’ and services’ evolution. Academic journals, market reports, and patents have been collected and reviewed on the topic of IoT in the logistics field in this paper. Moreover, by using TOA, technology opportunities have been analyzed to explore IoT-related logistics services. The results of TOA, for example, show that cloud technology is essential to develop smart logistics services, and communication RFID technologies are key to developing information logistics services. Finally, TSEA enables the observation of IoT technology and logistics service evolution by combining unstructured and semi-structured data from text documents. Observing the results of TSEA, the evolution of IoT in logistics is identified, and the results of TSEA also confirm those of TOA using unstructured or semi-structured text data from documents only. The results of this paper are discussed and compared with those of some previous review studies. In summary, the results of this paper provide methodological guidelines on this topic for a comprehensive understanding of IoT-related logistics services.
Mechanical criterion for coal and gas outburst: a perspective from multiphysics coupling
Authors: Liu Ting , Lin Baiquan , Fu Xuehai , Liu Ang 
Published: June 2021

AbstractAlthough a series of hypotheses have been proposed, the mechanism underlying coal and gas outburst remains unclear. Given the low-index outbursts encountered in mining practice, we attempt to explore this mechanism using a multiphysics coupling model considering the effects of coal strength and gas mass transfer on failure. Based on force analysis of coal ahead of the heading face, a risk identification index Cm and a critical criterion (Cm ≥ 1) of coal instability are proposed. According to this criterion, the driving force of an outburst consists of stress and gas pressure gradients along the heading direction of the roadway, whereas resistance depends on the shear and tensile strengths of the coal. The results show that outburst risk decreases slightly, followed by a rapid increase, with increasing vertical stress, whereas it decreases with increasing coal strength and increases with gas pressure monotonically. Using the response surface method, a coupled multi-factor model for the risk identification index is developed. The results indicate strong interactions among the controlling factors. Moreover, the critical values of the factors corresponding to outburst change depending on the environment of the coal seams, rather than being constants. As the buried depth of a coal seam increases, the critical values of gas pressure and coal strength decrease slightly, followed by a rapid increase. According to its controlling factors, outburst can be divided into stress-dominated, coal-strength-dominated, gas-pressure-dominated, and multi-factor compound types. Based on this classification, a classified control method is proposed to enable more targeted outburst prevention.