bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of chosen factors affecting the incidence of a brain stroke – a preliminary report.
Authors: KANTELUK ARTUR Andrzej , Krajewska-Kułak Elzbieta 
Published: April 2021

Abstract
The risk of stroke is directly proportional to the occurrence of hypertension and the simultaneous occurrence of other risk factors. The main goal was to find out which age group was most at risk of having a stroke. The study was performed among 138 people randomly chosen from Michałowo borough in the Białystok county.The examined were divided into the following 5 age group. The following measurements were performed: arterial blood pressure, blood glucose level, total cholesterol and its fractions level, triglycerides level, sodium and potassium level, prothrombine time, activity. Additionally, a patient’s history was taken and an author’s survey questionnaire was completed. Due to the small number of men surveyed (13 persons), statistically significant analysis of data within this group cannot be carried out. An analysis was made, broken down by age, of data obtained after examining 125 women. People in age group III are most at risk of developing stroke. People in the IV and V age groups are those who are at risk of having a stroke or who have had a stroke. People in groups 1 and 2 are at moderate risk of stroke. In the III age group people are the most at risk of having a stroke.
High-throughput, high-precision colony phenotyping with pyphe
Authors: Kamrad Stephan , Bähler Jürg , Ralser Markus 
Published: April 2021

Abstract
Colony fitness screens are powerful approaches for functional genomics and genetics. This protocol describes experimental and computational procedures for assaying the fitness of thousands of microbial strains in numerous conditions in parallel. Data analysis is based on pyphe, an all-in-one bioinformatics toolbox for scanning, image analysis, data normalisation and interpretation. We describe a standard protocol where endpoint colony areas are used as fitness proxy and two variations on this, one using colony growth curves and one using colony viability staining with phloxine B. Different strategies for experimental design, normalisation techniques and quality control are discussed. Using these approaches, it is possible to collect hundreds of thousands of data points, with low technical noise levels around 5%, in an experiment typically lasting two weeks or less.
Characteristics of local wastewater quality in the sulphate production of fibre semi-finished products
Authors: Боголицын К.Г. , Москалюк Е.А. , Костогоров Н.М. , Шульгина Е.В. , Иванченко Н.Л. 
Published: April 2021

Федеральным законом «Об охране окружающей среды» и отдельными законодательными актами России в области экологии основным направлением развития экономики определена гармонизация технологических и экологических решений с внедрением наилучших доступных технологий. Производство целлюлозы, бумаги, картона относится к наиболее водоемким производствам и в силу образования значительных объемов сточных вод, содержащих различные по химической природе компоненты, оказывает негативное воздействие на окружающую среду. Поэтому задача создания эффективной системы эколого-аналитического контроля качества сточных вод на всех стадиях технологического производства, очистки и выпуска в природные водоемы остается наиболее востребованной и актуальной. Обоснованы принципы построения системы внутрипроизводственного контроля интегрированного целлюлозно-бумажного предприятия по производству картона на основе обобщенных показателей качества локальных стоков. Показаны специфические особенности формирования и характеристики состава сточных вод сульфатцеллюлозного производства при совместном упаривании «черных» и «красных» щелоков.
The main direction of the development of economic is harmonization of technological and ecological solutions with the introduction of the best available technologies as stated by the Federal law “On environmental protection” and legislative acts of the Russian Federation. The production of cellulose, paper, and cardboard is one of the most water-consuming industries and due to the formation of the significant volumes of wastewaters containing various chemical components have a negative impact on the environment. Therefore, the aim of the creating of a system of the effective ecological and analytical control of wastewaters’ quality at all stages of technological production; their purification and release into natural waters remains the most in demand and urgent. In the present article the principles of creation of the system in-house control of an integrated pulp and paper mill producing the cardboard based on the generalized indicators of local effluents’ quality. The specific features of the formation and characterization of the composition of wastewaters from cellulose sulfate production with the joint evaporation of the “black” and “red” liquors.
Concordance of two polymerase chain reaction–based blood group genotyping platforms for patients with sickle cell disease
Authors: Sheppard C.A. , Bolen N.L. , Meny G. , Kalvelage M. , Ochoa-Garay G. 
Published: April 2021

Abstract
In recent years, polymerase chain reaction–based genotyping platforms, which provide a predicted phenotype, have increased in both patient and high-throughput donor testing, especially in situations where serologic methods or reagents are limited. This study looks at the concordance rate between two platforms commercially available in the United States when used for testing samples from patients with sickle cell disease (SCD), a group particularly vulnerable to alloimmunization. DNA extracted from samples from 138 patients with SCD was tested by human erythrocyte antigen (HEA) BeadChip (Immucor, Norcross, GA) and by ID CORE XT (Progenika-Grifols, Barcelona, Spain). Predicted phenotype results were compared, and a concordance rate was calculated. Discrepancies were resolved by Sanger sequencing. All testing was done under an institutional review board–approved protocol. A concordance rate of 99.9 percent was obtained. Sanger sequencing was performed on four samples with discrepancies in the Rh blood group system. Three samples had a similar allelic variant detected by ID CORE XT. Two of the three discrepant samples were correctly identified as V+w, VS− by ID CORE XT but not by HEA BeadChip. The third sample, predicted to have a phenotype of V+, VS+ by sequencing, was called correctly by HEA BeadChip but not by ID CORE XT, which had predicted V+w, VS−. The fourth discrepancy was identified in a sample that ID CORE XT accurately identified as RHCE*ce[712G] and predicted a partial c phenotype. This result was confirmed by Sanger sequencing, whereas HEA BeadChip found no variants and predicted a c+ phenotype. The high concordance rate of the two methods, along with the known limitations of serology, warrant further discussion regarding the practice of serologic confirmation of extended phenotypes. Clinical significance of the identified discrepancies remains to be determined.
Prediction of river water temperature using machine learning algorithms: a tropical river system of India
Authors: Rajesh M. , Rehana S. 
Published: April 2021

Abstract
Machine learning (ML) has been increasingly adopted due to its ability to model complex and non-linearities between river water temperature (RWT) and its predictors (e.g., Air Temperature, AT). Most of these ML approaches have been applied using average AT without any detailed sensitivity analysis of other forms of AT (e.g., maximum and minimum). The present study demonstrates how new ML approaches, such as ridge regression (RR), K-nearest neighbors (KNN) regressor, random forest (RF) regressor, and support vector regression (SVR), can be coupled with Sobol’ global sensitivity analysis (GSA) to predict accurate RWT estimates with the most appropriate form of AT. Furthermore, the proposed ML approaches have been combined with the Ensemble Kalman Filter (EnKF), a data assimilation (DA) technique to improve the predicted values based on the measured data. The proposed modelling framework's effectiveness is demonstrated with a tropical river system of India, Tunga-Bhadra River, as a case study. The SVR has been noted as the most robust ML model to predict RWT at a monthly time scale compared with daily and seasonal. The study demonstrates how ML methods can be coupled with a global sensitivity algorithm and DA techniques to generate accurate RWT predictions in river water quality modelling.
Effect of operational parameters and material properties on hardness removal efficiency by electrochemical technique
Authors: Wang Wei , Chen Qi , Lin Wei , Zheng Xiaotao , Xu Jianmin , Yu Jiuyang 
Published: April 2021

Abstract
Electrochemical water treatment technology can be used for hard water softening, but its removal efficiency and energy consumption problems hinder its application. The effects of electrolysis voltage and cathode materials on efficiency, energy consumption and scale crystal form of electrochemical water treatment technology were studied experimentally. The experimental results show that electrochemical water treatment can effectively remove more than 40% of the TDS (total dissolved solids) in the influent. The electrolysis voltage has a great influence on the removal rate of hardness ions. The optimum electrolytic voltage for the titanium plate cathode is 25 V. At this electrolytic voltage, the treatment capacity of the titanium plate cathode is 16% higher than that of the copper plate cathode, and the energy consumption is 16% lower than that of the copper plate. Titanium plates are more efficient than copper plates and consume less energy. The effects of electrochemical water treatment on the scale crystal form were investigated by SEM (scanning electron microscopy) and XRD (X-ray diffraction). Electrochemical water treatment increases the mass fraction of aragonite in the calcium carbonate scale and changed the microscopic surface structure of calcium carbonate scale.
Facile one step green synthesis of iron nanoparticles using grape leaves extract: textile dye decolorization and wastewater treatment
Authors: Raman Chandra Devi , Sellappa Kanmani , Mkandawire Martin 
Published: April 2021

Abstract
The existing knowledge on the reactivity of green iron particles on textile dye and wastewater decolorization is very limited. In this study, the potential of green iron particles synthesized using grape leaves extract on reactive dye (reactive red 195, reactive yellow 145, reactive blue 4 and reactive black 5) decolorization were investigated. 95–98% of decolorization was achieved for all reactive dyes at 1.4–2.0 g/L of green iron. Maximum decolorization was attained at lower dye concentration and showed very little impact on decolorization when pH was increased from 3 to 11. The pseudo-first-order fit confirms the reaction between iron particles and dye molecules with rate constant 0.317–0.422 and it is followed by adsorption, data fit with pseudo-second-order model. Hence, not only adsorption but also the reduction process is involved in the reactive dye decolorization. Benzene, phenyl sodium, 2-chloro-1,3,5-triazine, naphthalene, sodium benzene sulfonate, benzene 1,2 di amine, anthracene-9,10 dione, aniline, phenol, benzene sulfonic acid were the major intermediates detected in dye decolorization and the respective reaction pathway is proposed. Green iron from grape leaves extract demonstrated better performance and it is recognized as the promising cost-effective material for textile wastewater treatment.
Focusing the Controversies in Budd-Chiari Syndrome Management
Authors: Mancuso Andrea 
Published: April 2021

:
Budd-Chiari Syndrome (BCS) is characterized by significant clinical and pathophysiological
aspects that seem to allow a sharp differentiation between a variant in the West from one in
the East.
The aim of this paper is to focus on the main issues and controversies about the management of BCS
in the West. The study discusses different treatment options and how research is trying to solve controversies
about debated topics, such as the timing of treatment. In fact, guidelines regarding management
of BCS suggest a step-wise strategy starting with medical therapy, arriving at revascularization
or TIPS as the second step, and culminating to liver transplant as rescue therapy.
However, long-term outcome is frequently dismal on sole medical therapy. In fact, it is a matter of
debate whether further intervention should be suggested only when hemodynamic consequences of
portal hypertension are evident. However, as recently hypothesized, chronic micro-vascular ischemia
due to impaired venous hepatic outflow could trigger liver fibrosis, resulting in portal hypertension
and progressive liver failure. Consequently, liver congestion relief through treatment might be useful
as a preventive tool. Recently, early TIPS proved to improve BCS outcome. A direct comparison of
early intervention versus step-wise strategy would seem advisable. Furthermore, further studies
should address whether non-invasive tools could predict which patients benefit from early intervention.
PRINCIPLES OF FORMING DEONTOLOGICAL READINESS OF SPECIALISTS IN PHYSICAL THERAPY, ERGOTHERAPY FOR PROFESSIONAL ACTIVITIES
Authors: Bespalova О. О. , Lytvynenko V. А. , Bugaenko T. V. , Mezentseva I. V. , Savchuk І. V. 
Published: April 2021

Резюме. Трудова діяльність фізичних терапевтів, ерготерапевтів передбачає професійно-комунікативну взаємодію між членами мультідисциплінарної команди, де знанням нормативно-правової бази щодо морально-етичних та правових норм поведінки і належного обов’язку відведена провідна роль. Це обумовлює потребу в оптимізації їх професійної підготовки при формуванні знань та умінь будувати професійні відносини в системі «людина-людина», де провідна роль належить дидактичним принципам.
Мета дослідження: визначення та теоретичне обґрунтування специфічних принципів деонтологічної підготовки майбутніх фахівців з фізичної терапії, ерготерапії.
Методи дослідження: теоретичні (аналіз, систематизація науково-методичної та нормативно-правової літератури у напрямку професійної підготовки фізичних терапевтів, ерготерапевтів); термінологічний аналіз для визначення змісту та сутності базових понять дослідження. Деонтологічна підготовка – динамічний процес набуття фахівцем ціннісних професійних орієнтацій, засвоєння загальнолюдських і фахових морально-етичних норм та принципів поведінки та слідування їм; розвиток соціальних та ділових якостей особистості, а також професійно-комунікативних умінь для успішного здійснення трудової діяльності. Деонтологічна підготовка фахівців з фізичної терапії, ерготерапії відбувається через систему загальнодидактичних та специфічних принципів, які націлюють навчальний процес на формування деонтологічних знань та умінь здійснювати професійну діяльність відповідно до морально-етичного кодексу. Провідними вважаємо: принцип соціальної обумовленості, принцип гуманізації, принцип міцності засвоєння знань, принцип практичної спрямованості навчання, принцип ситуативності.
USE OF ERYTHROCYTIC CONTAINERS FOR DELIVERY OF MEDICINES TO THE INFLAMMATION SITE
Authors: Churpiy І. К. , Golod N. R. , Yaniv О. V. , Fedorivska L. P. , Fitsych M. V. , Macogin А. Р. 
Published: April 2021

Abstract. In recent decades, scientists have been attracted by the idea of developing methods for targeted transport of drugs and diagnostic drugs directly into the area of inflammation.
Experimental and single clinical studies have revealed high efficiency and prospects for targeted delivery of various drugs. Most known carriers have a number of disadvantages, both in the range and amount of drugs they can bind, and in their ability to prevent contact of transport drugs with healthy tissues. In addition, there are difficulties associated with the toxicity and immunogenicity of carriers, their availability, cost, complexity of preparation. Transport systems that use the body's own cells are the most advantageous in terms of biocompatibility. Among them, erythrocytes, platelets and leukocytes are used as vehicles.
Currently, the most promising in terms of drug transport is the use of erythrocyte containers.
Pharmacokinetic studies have shown that with this route of administration, the concentration of antibiotic in the bile in patients with inflammatory diseases of the biliary tract, 4.7 times higher than with other routes of administration, and their therapeutic activity is maintained for a much longer time. When the erythrocyte containers were applied topically, the antibiotic concentration in the wound and surrounding tissue was 10 times higher than that achieved by traditional soft tissue puncture.
In order to prove the ability of erythrocyte containers to capture drugs and concentrate in the inflammatory focus in 10 patients with this pathology at the beginning of treatment was injected into the femoral artery 1% - 1 ml of nicotinic acid in 0.9% - 2 ml of saline, and the following day the same patient in the same dose it was administered in erythrocyte containers. The time of onset of the reaction and the duration of the drug were determined, taking into account subjective and objective data.
The ability of erythrocyte containers to seize drugs is evidenced by the results obtained by us: with the introduction of nicotinic acid in its pure form, the reaction occurred after 115411 ± 0,0411and lasted 715211 ± 0,0311. Objectively, there was a gradual reddening of the face and mild hyperemia. With the introduction of erythrocyte containers with nicotinic acid, the reaction occurred through 214311 ± 0,0311 and lasted 1112411 ± 0,0211.
Subjectively, patients were characterized by a milder course of the reaction.
The development of granulation tissue in the wound with the introduction of erythrocyte containers with antibiotics began on day 8-9, and the marginal epithelialization - on day 10-12. In the control group, the appearance of granulation tissue and epithelialization in the wound were on 12-13 and 14-15 days, respectively.
Requirements and Operational Guidelines for Secure and Sustainable Digital Phenotyping: Design and Development Study
Authors: Jagesar Raj R , Vorstman Jacob A , Kas Martien J 
Published: April 2021

Background
Digital phenotyping, the measurement of human behavioral phenotypes using personal devices, is rapidly gaining popularity. Novel initiatives, ranging from software prototypes to user-ready research platforms, are innovating the field of biomedical research and health care apps. One example is the BEHAPP project, which offers a fully managed digital phenotyping platform as a service. The innovative potential of digital phenotyping strategies resides among others in their capacity to objectively capture measurable and quantitative components of human behavior, such as diurnal rhythm, movement patterns, and communication, in a real-world setting. The rapid development of this field underscores the importance of reliability and safety of the platforms on which these novel tools are operated. Large-scale studies and regulated research spaces (eg, the pharmaceutical industry) have strict requirements for the software-based solutions they use. Security and sustainability are key to ensuring continuity and trust. However, the majority of behavioral monitoring initiatives have not originated primarily in these regulated research spaces, which may be why these components have been somewhat overlooked, impeding the further development and implementation of such platforms in a secure and sustainable way.

Objective
This study aims to provide a primer on the requirements and operational guidelines for the development and operation of a secure behavioral monitoring platform.

Methods
We draw from disciplines such as privacy law, information, and computer science to identify a set of requirements and operational guidelines focused on security and sustainability. Taken together, the requirements and guidelines form the foundation of the design and implementation of the BEHAPP behavioral monitoring platform.

Results
We present the base BEHAPP data collection and analysis flow and explain how the various concepts from security and sustainability are addressed in the design.

Conclusions
Digital phenotyping initiatives are steadily maturing. This study helps the field and surrounding stakeholders to reflect upon and progress toward secure and sustainable operation of digital phenotyping–driven research.
Method for Reducing the Amplitude Error of the Magnetic Comparator
Authors: Lomaev G. V. , Andryushaev K. A. 
Published: April 2021

Выходные сигналы датчиков при контроле ферромагнитных материалов методом эффекта Баркгаузена (метод неразрушающего контроля, основанный на регистрации параметров cкачков намагниченности, возникающих в результате эффекта Баркгаузена) представляют собой поток импульсов ЭДС от скачков Баркгаузена. Он имеет статистический характер (так называемый магнитный шум). При большом их количестве за полуцикл перемагничивания осуществляют либо скользящее усреднение, либо за весь полуцикл.В бистабильных ферромагнетиках флуктуации выходных сигналов датчика (а последние представляют два импульса разной полярности за цикл перемагничивания) не могут быть усреднены без потери информации, что снижает метрологические характеристики всего устройства. Флуктуируют такие параметры, как амплитуда, длительность, поле старта. Это ограничивает применение его в точных измерениях.Для разработки способа повышения стабильности выходного сигнала датчика использована гипотеза о полном переключении объема бистабильного образца ферромагнитного материала при скачке Баркгаузена. Гипотеза основана на новых физических данных, полученных при исследовании бистабильных ферромагнетиков авторами С. А. Барановым, Г. В. Ломаевым, С. П. Ахизиной, Г. В. Каримовой и другими.Предложен способ уменьшения флуктуаций амплитуды импульса ЭДС на выходе магнитного компаратора, заключающийся в преобразовании вольт-секундной площади в импульс, пропорциональный амплитуде. Разработана простая и надежная схема, реализующая данный способ. Проведена серия экспериментов. Показано, что флуктуация выходного сигнала уменьшается при использовании разработанного способа почти на порядок.Апробация способа осуществлялась на сердечниках из сплава викаллой 2 (Co52Fe38V10), подвергнутых крутильной деформации до предела текучести по технологии, разработанной на кафедре «Приборы и методы измерения, контроля и диагностики» ИжГТУ имени М. Т. Калашникова.
FLOWSTANDART PHONOPNEUMOGRAPHY QUIET BREATHING IN THE DIAGNOSIS OF COMORBID CURRENT COMMUNITYACQUIRED PNEUMONIA
Authors: Malinina E. V. , Dubinkin V. A. 
Published: April 2021

The aim of our study was to estimate the potential of the flow about standardized panoramogram quiet breathing (PFPG SD) for the diagnosis of inflammation in patients with community-acquired pneumonia on a background of chronic obstructive pulmonary disease (COPD).Materials and methods: 36 healthy male volunteers aged 18 to 76 years old and 36 men with CAP on the background of COPD aged 45 to 80 years old, hospitalized in the Department of the Ministry of Defense of the Far East Branch of the Russian Academy of Sciences, and were examined. PFPG SD was performed on admission to all patients and healthy individuals.Results and discussion: Spectral criteria for acoustic diagnostics of the focus of patients with CAP on the background of COPD were developed, determined by PFPG SD. The maximum specificity for the group of healthy people was reached — 80,5%, the maximum sensitivity of detecting the focus of inflammation — 83,3%. The sensitivity of PFPG SD exceeds the sensitivity of subjective auscultation. The types of acoustic pattern and their threshold values for patients were revealed.