bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trump’s and Biden’s styles during the 2020 US presidential election
Authors: Savoy Jacques , Wehren Marylène 
Published: April 2021

AbstractThis study analyzes the stylistic and rhetorical characteristics of Donald Trump and Joe Biden during the 2020 US presidential election. As communication channels, the oral (TV debates and radio interviews), written speeches, and tweets sent during the last 2 months have been examined. As stylometric markers, the most frequent functional words indicate that Trump employs more diverse personal pronouns more frequently than Biden. For the Democratic nominee, the first-person pronouns (I and we) are mainly used with, compared to Trump, a higher rate of prepositions, signaling the use of a larger number of nouns. When comparing the three media of communication, this study shows that the oral form is closer to the written one and that tweet-based communication presents a distinct type compared with the other two. Usually, written texts tend to contain more functional words than either the oral form or tweets. When comparing the two nominees, the frequency of familiar words (e.g. the, to, of, a) tends to be higher in Biden’s addresses, whereas Trump opts more often for grandiose terms (e.g. great, just, strong). As rhetorical features, the Republican president uses more emotional words, both positive and negative. The Democratic candidate does not propound negative messages and opts for symbolic (e.g. nation, country) and achievement terms (e.g. plan, win, work) with numerous references to people and family (e.g. folks, Americans, son).
Infrared variable stars in the compact elliptical galaxy M32
Authors: Jones O C , Nally C , Sharp M J , McDonald I , Boyer M L , Meixner M , Kemper F , Ferguson A M N , Goldman S R , Rich R M 
Published: April 2021

ABSTRACT
Variable stars in the compact elliptical galaxy M32 are identified, using three epochs of photometry from the Spitzer Space Telescope at 3.6 and 4.5 μm, separated by 32 to 381 d. We present a high-fidelity catalogue of sources detected in multiple epochs at both 3.6 and 4.5 μm, which we analysed for stellar variability using a joint probability error-weighted flux difference. Of these, 83 stars are identified as candidate large-amplitude, long-period variables, with 28 considered high-confidence variables. The majority of the variable stars are classified as asymptotic giant branch star candidates using colour-magnitude diagrams. We find no evidence supporting a younger, infrared-bright stellar population in our M32 field.
MrHAMER yields highly accurate single molecule viral sequences enabling analysis of intra-host evolution
Authors: Gallardo Christian M , Wang Shiyi , Montiel-Garcia Daniel J , Little Susan J , Smith Davey M , Routh Andrew L , Torbett Bruce E 
Published: April 2021

Abstract
Technical challenges remain in the sequencing of RNA viruses due to their high intra-host diversity. This bottleneck is particularly pronounced when interrogating long-range co-evolved genetic interactions given the read-length limitations of next-generation sequencing platforms. This has hampered the direct observation of these genetic interactions that code for protein-protein interfaces with relevance in both drug and vaccine development. Here we overcome these technical limitations by developing a nanopore-based long-range viral sequencing pipeline that yields accurate single molecule sequences of circulating virions from clinical samples. We demonstrate its utility in observing the evolution of individual HIV Gag-Pol genomes in response to antiviral pressure. Our pipeline, called Multi-read Hairpin Mediated Error-correction Reaction (MrHAMER), yields &gt;1000s of viral genomes per sample at 99.9% accuracy, maintains the original proportion of sequenced virions present in a complex mixture, and allows the detection of rare viral genomes with their associated mutations present at &lt;1% frequency. This method facilitates scalable investigation of genetic correlates of resistance to both antiviral therapy and immune pressure and enables the identification of novel host-viral and viral-viral interfaces that can be modulated for therapeutic benefit.
MutationTaster2021
Authors: Steinhaus Robin , Proft Sebastian , Schuelke Markus , Cooper David N , Schwarz Jana Marie , Seelow Dominik 
Published: April 2021

Abstract
Here we present an update to MutationTaster, our DNA variant effect prediction tool. The new version uses a different prediction model and attains higher accuracy than its predecessor, especially for rare benign variants. In addition, we have integrated many sources of data that only became available after the last release (such as gnomAD and ExAC pLI scores) and changed the splice site prediction model. To more easily assess the relevance of detected known disease mutations to the clinical phenotype of the patient, MutationTaster now provides information on the diseases they cause. Further changes represent a major overhaul of the interfaces to increase user-friendliness whilst many changes under the hood have been designed to accelerate the processing of uploaded VCF files. We also offer an API for the rapid automated query of smaller numbers of variants from within other software. MutationTaster2021 integrates our disease mutation search engine, MutationDistiller, to prioritise variants from VCF files using the patient's clinical phenotype. The novel version is available at https://www.genecascade.org/MutationTaster2021/. This website is free and open to all users and there is no login requirement.
Light-induced degradation of SPA2 via its N-terminal kinase domain is required for photomorphogenesis
Authors: Schenk Tobias , Trimborn Laura , Chen Song , Schenkel Christian , Hoecker Ute 
Published: April 2021

Abstract
Arabidopsis (Arabidopsis thaliana) CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1) and members of the SUPPRESSOR OF PHYTOCHROMEA-105 (SPA) protein family form an E3 ubiquitin ligase that suppresses light signaling in darkness by polyubiquitinating positive regulators of the light response. COP1/SPA is inactivated by light to allow photomorphogenesis to proceed. Mechanisms of inactivation include light-induced degradation of SPA1 and, in particular, SPA2, corresponding to a particularly efficient inactivation of COP1/SPA2 by light. Here, we show that SPA3 and SPA4 proteins are stable in the light, indicating that light-induced destabilization is specific to SPA1 and SPA2, possibly related to the predominant function of SPA1 and SPA2 in dark-grown etiolating seedlings. SPA2 degradation involves cullin and the COP10-DEETIOLATED-DAMAGED-DNA BINDING PROTEIN (DDB1) CDD complex, besides COP1. Consistent with this finding, light-induced SPA2 degradation required the DDB1-interacting Trp-Asp (WD)-repeat domain of SPA2. Deletion of the N-terminus of SPA2 containing the kinase domain led to strong stabilization of SPA2 in darkness and fully abolished light-induced degradation of SPA2. This prevented seedling de-etiolation even in very strong far-red and blue light and reduced de-etiolation in red light, indicating destabilization of SPA2 through its N-terminal domain is essential for light response. SPA2 is exclusively destabilized by phytochrome A in far-red and blue light. However, deletion of the N-terminal domain of SPA2 did not abolish SPA2-phytochrome A interaction in yeast nor in vivo. Our domain mapping suggests there are two SPA2-phytochrome A interacting domains, the N-terminal domain and the WD-repeat domain. Conferring a light-induced SPA2-phyA interaction only via the WD-repeat domain may thus not lead to COP1/SPA2 inactivation.
Habitual Path Dependence of Interorganizational Relationships?—A Commentary on Sedgwick and Jensen
Authors: Sydow Jörg 
Published: April 2021

Abstract
This is a commentary to a former paper by Sedwick and Jensen published in this very journal. On the one hand, the commentary praises the paper’s urgently needed focus on interorganizational relationships and empirical richness. On the other, the commentary questions habitual path dependence as a theoretically useful concept.
Death, Creation, and Future Bias
Authors: Rabenberg Michael 
Published: April 2021

Abstract
A much discussed question in the philosophy of death is whether both of the following claims are true: (1) it is at least typically appropriate to prefer dying further in the future to dying less far in the future; and (2) it is at least typically appropriate not to prefer having been created further in the past to having been created less far in the past. Some philosophers have tried to defend (1) and (2) by appeal to the alleged appropriateness of future bias—roughly, greater concern for certain goods and bads in one's future than for certain goods and bads in one's past. I argue that such approaches to defending (1) and (2) probably cannot succeed, by arguing that even if a very strong version of future bias is appropriate, it does not follow that (1) and (2) are both true. Philosophers attracted to the conjunction of (1) and (2) ought to try to defend it by appeal to something other than future bias.
Personality and insomnia symptoms in older adults: the Baltimore Longitudinal Study of Aging
Authors: Rojo-Wissar Darlynn M , Wanigatunga Amal A , Simonsick Eleanor M , Terracciano Antonio , Wu Mark N , Zipunnikov Vadim , Schrack Jennifer A , Hossain Sharmin , Ferrucci Luigi , Costa Paul T , Spira Adam P 
Published: April 2021

Abstract

Study Objective
To examine associations of personality dimensions and facets with insomnia symptoms in a community sample of older adults.

Methods
We studied 1049 participants aged 60–97 years in the Baltimore Longitudinal Study of Aging. Personality was assessed by the Revised NEO Personality Inventory (NEO-PI-R), and insomnia symptom severity was measured by the Women’s Health Initiative Insomnia Rating Scale (WHIIRS).

Results
Adjusting for demographic characteristics, higher neuroticism, lower conscientiousness, and lower extraversion were associated with greater insomnia symptom severity. These associations remained significant for neuroticism and conscientiousness when further adjusting for depressive symptoms and comorbidities. Higher scores on neuroticism facets Anxiety, Angry Hostility, and Depression, and lower scores on conscientiousness facets Competence, Order, and Achievement Striving and on agreeableness facet Altruism were associated with greater insomnia symptom severity in fully adjusted models. Results were similar among cognitively normal older adults (N = 966), except higher scores on extraversion facets Warmth and Assertiveness associated with lower insomnia symptom severity, and agreeableness facet Altruism was unassociated.

Conclusion
Among older adults, insomnia symptoms appear partially related to personality, with persons higher in neuroticism experiencing greater insomnia symptom severity, and those higher in conscientiousness experiencing lower insomnia symptom severity. Exploring facets of the Big-Five dimensions may provide additional insight regarding the etiology and resolution of sleep disturbance, and some of these associations may differ based on cognitive status. Future studies should investigate the hypothesis that sleep impairment mediates part of the association between specific personality traits and health-related outcomes.
The interplay between anxiety, fear, protective behaviors, compassion, and resilience among older adults during a COVID-19 lockdown: a structural equation modeling study
Authors: Lim Xin Ying , Yap Ai Che , Mahendran Rathi , Yu Junhong 
Published: April 2021

Abstract
The implementation of lockdown measures to curb the transmission of Coronavirus disease-2019 (COVID-19) has brought about significant psychological impacts and older adults have been identified as one of the vulnerable groups. In the current COVID-19 context among older adults in the community, the fear of COVID-19, anxiety symptoms, compassion, resilience, and the practice of protective behaviors are possibly related to each other in several ways. How these factors relate to each other would have important implications in managing the spread of the disease and its mental health consequences. To this end, we modeled their interrelationships using a structural equation model. Older adults (N = 421), aged 60 and above completed various questionnaires—COVID-19 Fear Inventory, Short form of the Geriatric Anxiety Inventory, COVID-19 Risky and Protective Behaviours, Resilience Appraisals Scale, and Compassion Scale during a COVID-19 lockdown. The relationships between these variables were assessed within a structural equation model. The findings showed that older adults who are more compassionate engage in protective behaviors more frequently. Additionally, frequent practice of protective behaviors and greater resilience predicted lower anxiety among older adults. Greater fear predicted higher anxiety levels but did not significantly influence an individual’s engagement in protective behaviors. Mental health services are crucial in fostering resilience and supporting older adults psychologically. Social services are also necessary in maintaining and enhancing social support for older adults. Importantly, these findings suggest that public health communications could promote compassion and avoid using a fear-based approach to increase engagement in protective behaviors.
Insight into Canary Island pine physiology provided by stable isotope patterns of water and plant tissues along an altitudinal gradient
Authors: Miranda José Carlos , Lehmann Marco M , Saurer Matthias , Altman Jan , Treydte Kerstin 
Published: April 2021

Abstract
The Canary Islands, an archipelago east of Morocco’s Atlantic coast, present steep altitudinal gradients covering various climatic zones from hot deserts to subalpine Mediterranean, passing through fog-influenced cloud forests. Unlike the majority of the Canarian flora, Pinus canariensis C. Sm. ex DC. in Buch grow along most of these gradients, allowing the study of plant functioning in contrasting ecosystems. Here we assess the water sources (precipitation, fog) of P. canariensis and its physiological behavior in its different natural environments. We analyzed carbon and oxygen isotope ratios of water and organics from atmosphere, soil and different plant organs and tissues (including 10-year annual time series of tree-ring cellulose) of six sites from 480 to 1990 m above sea level on the Canary Island La Palma. We found a decreasing δ18O trend in source water that was overridden by an increasing δ18O trend in needle water, leaf assimilates and tree-ring cellulose with increasing altitude, suggesting site-specific tree physiological responses to relative humidity. Fog-influenced and fog-free sites showed similar δ13C values, suggesting photosynthetic activity to be limited by stomatal closure and irradiance at certain periods. In addition, we observed an 18O-depletion (fog-free and timberline sites) and 13C-depletion (fog-influenced and fog-free sites) in latewood compared with earlywood caused by seasonal differences in: (i) water uptake (i.e., deeper ground water during summer drought, fog water frequency and interception) and (ii) meteorological conditions (stem radial growth and latewood δ18O correlated with winter precipitation). In addition, we found evidence for foliar water uptake and strong isotopic gradients along the pine needle axis in water and assimilates. These gradients are likely the reason for an unexpected underestimation of pine needle water δ18O when applying standard leaf water δ18O models. Our results indicate that soil water availability and air humidity conditions are the main drivers of the physiological behavior of pine along the Canary Island’s altitudinal gradients.
Urosepsis and the urologist!
Authors: Ryan James , O’Neill Eoghan , McLornan Liza 
Published: April 2021

Abstract

Introduction:
Sepsis is a life-threatening organ dysfunction that is caused by a dysregulated host response to the infection. Urosepsis contributes up to 25% of all sepsis cases. An important part of the management of urosepsis is to rule out possible surgical causes such as urolithiasis, obstructive uropathy, or abscess formation along the urogenital tract.

Objective:
The aim of this study is to look at whether urological conditions and recent urological surgery contribute significantly to all patients admitted with urosepsis.

Methods:
A total of 2679 urine cultures and 654 blood cultures performed in Connolly Hospital Emergency Department were reviewed between 2016 and 2018. Patients were included if they had a matching urine culture and blood culture performed within 24 hours of admission. A retrospective chart review was performed for all patients included in the study.

Results:
Our study included 85 patients admitted with urosepsis between 2016 and 2018. The average age was 70.3 years (21–100 years), in which 61% (n = 52) of patients were female, 18% (n = 16) had a long-term indwelling catheter, 11.8% (n = 10) were admitted as urosepsis with a urological condition. The most common urological condition predisposing patients to urosepsis in this study was bladder outlet obstruction secondary to benign prostatic hyperplasia. A total of 4.7% (n = 4) of patients died during their admission. The complications as a result of urosepsis included a prostatic abscess, a psoas abscess, an ileus, an infected cyst, and 1 case of emphysematous pyelonephritis.

Conclusion:
In this study, the majority of patients admitted with urosepsis did not have an underlying urological condition or recent urological instrumentation. Clinicians should be aware of potential complications as a result of a urosepsis.
Exploring Stakeholder Service Navigation Needs for Children with Developmental and Mental Health Diagnoses
Authors: Yaseen Wid , Steckle Valerie , Sgro Michael , Barozzino Tony , Suleman Shazeen 
Published: April 2021

Abstract:

Objective:
Service navigation programs are necessary for children with neurodevelopmental and/or mental health diagnoses to facilitate access to specialized therapies, social services, and community programs, especially those who are socially and economically marginalized. Few studies have included diverse stakeholders in the development and implementation of such programs in resource-limited settings. In this qualitative formative study, we aimed to explore stakeholder experiences after the implementation of a pilot service navigation program in resource-limited settings and identify the perceived elements of an effective service navigator, to develop a revised service navigation program for this patient population.

Methods:
A novel navigation pilot program was implemented in an urban inner-city setting. Using phenomenology as a methodology, we conducted qualitative in-depth interviews with patient caregivers, pediatricians, allied health staff, clinic administrators, and the patient navigator. Data were analyzed within and across stakeholder groups using thematic analysis and supported by group discussion.

Results:
Twenty-five stakeholders participated. All stakeholders reported challenges with accessing services before the implementation of the navigation program. Caregivers expressed frustration navigating a fragmented health care system, while providers felt limited by time and knowledge. The navigator's role was described as multifaceted: finding and completing applications for funding and programs, offering emotional support, liaising between physicians and patients, and advocating with schools and agencies. Based on stakeholder input, a revised service navigation model of care is proposed.

Conclusion:
Caregivers and providers face immense barriers trying to help children with mental health and developmental diagnoses access necessary services and funding. Service navigation programs can be effectively embedded within pediatric clinical teams to improve access to required services for this patient population.
A Longitudinal Study of Assisted Infant Toilet Training During the First Year of Life
Authors: Bender Jeffrey M. , Lee Yelim , Ryoo Ji Hoon , Boucke Laurie , Sun Min , Ball Thomas S. , Rugolotto Simone , She Rosemary C. 
Published: April 2021

ABSTRACT:

Objective:
Previous retrospective studies have examined elimination signals, stool toileting refusal, and completion age in Assisted Infant Toilet Training (AITT). The aim of this longitudinal cohort study was to describe the practice of AITT and caregiver satisfaction in a primarily Western setting during the first year of life.

Methods:
Families who started AITT before 4 months of age were recruited. Standardized interviews of caregivers were conducted at 1- to 2-month intervals. To identify trends over time, data were fitted to a linear mixed-effect model. Data were analyzed according to five 2-month blocks, starting at 3 to 4 months.

Results:
Of 85 participating families, 87 children started AITT at a mean age of 2.5 months. At all age intervals, 88% to 94% of caregivers could identify elimination signals. Toileting attempts decreased from 10/day at 3 to 4 months to 7/day at 11 to 12 months (p < 0.001). Many families (45%–53%) practiced AITT on a part-time basis. Daytime dryness was noted in 12% to 14% of infants throughout the first year. Although more than 63% of families used cloth or disposable diapers throughout this study, use of trainers and underwear increased significantly by 2- to 3-fold (p < 0.01 for both). Caregiver satisfaction was high overall. Although negatively associated with potty refusal, it was positively associated with daytime and nighttime dryness, perceived elimination signals, and a better understanding of their infant's needs (p < 0.001 for all).

Conclusion:
This study demonstrates that AITT is a worthy viable alternative to the use of diapers even in Western settings. Better understanding of AITT provides a new perspective to properly meet infants' basic needs.
Peer Relationship Trajectories in Very Preterm and Term Individuals from Childhood to Early Adulthood
Authors: Reyes Lucia M. , Jaekel Julia , Bartmann Peter , Wolke Dieter 
Published: April 2021

ABSTRACT:

Objective:
To identify trajectories of peer relationships in very preterm and term-born individuals from 6 to 26 years of age and test early-life predictors of these trajectories.

Method:
As part of the Bavarian Longitudinal Study, 218 very preterm/very low birth weight (VP/VLBW; <32 weeks' gestation/<1500 grams) and 220 healthy term-born (37–42 weeks' gestation) individuals were followed prospectively from birth to adulthood. Parent and self-reports at 6, 8, 13, and 26 years were combined into comprehensive developmentally appropriate scores across 3 domains: peer acceptance, friendships, and peer problems. Latent profile analyses were used to identify trajectories across these 3 domains. Binary and multinomial logistic regressions were used to test the following potential predictors of trajectories: VP/VLBW status, sex, socioeconomic status, neonatal medical risk, parent-infant relationship at 5 months, child inhibitory control at 20 months, and child cognitive abilities at 20 months.

Results:
Three trajectories were identified for peer acceptance and friendships, and 2 trajectories were identified for peer problems. Higher cognitive abilities predicted more optimal trajectories in peer acceptance (odds ratio: 1.03 [95% confidence interval = 1.01–1.05]), friendships (1.03 [1.00–1.05]), and peer problems (1.06 [1.04–1.09]). In addition, good parent-infant relationships predicted lower peer problem trajectories (1.61 [1.03–2.50]).

Conclusion:
Early cognitive deficits may underlie persistent peer relationship difficulties in VP/VLBW samples. Positive parent-infant relationships may help reduce preterm children's risk for long-term peer problems.