bluuebunny/crossref_metadata_2025_split huggingface dataset:
An anthropometric evaluation of the augmented breast: differences between cis-and transgender women and possible clinical implications
Authors: Wilhelmus Timmermans Floyd , Elisabeth Mokken Sterre , Scheffers Brian , Bouman Mark-Bram , Mullender Margriet , van de Grift Tim 
Published: July 2021

Abstract
Background
The morphometric results after breast augmentations are generally understood to be clinically different between trans(gender) and cis(gender) women. The objective of this study was to establish these morphometric differences between the augmented breasts of trans and cis women and their implications for preoperative planning and expectation management of trans women.

Methods
A single-center, observational cross-sectional study was conducted. Three-dimensional images (VECTRA) of the chest were taken and used to measure preset morphometric parameters. Subsequently, several proportional morphometric outcome variables were calculated. We compared body, breast, and nipple dimensions and their interdependence between trans and cis women. The main outcome sets were (1) the relative dimensions of the chest, (2) the position of the breasts relative to the chest, (3) and the position of the nipple relative to the breast and nipple size.

Results
A total of 22 transgender and 22 cisgender women were included. The results showed that the breasts of the trans women were positioned more cranial. Furthermore, the nipple-areola complexes (NAC) were significantly smaller and positioned relatively more latero-cranial on the breasts.

Conclusions
Morphological characteristics of augmented breasts differ significantly between trans and cis women. The results of this study identified distinct differences between the augmented breasts of trans and cis women. Because of the apparent differences in results, surgical considerations, expectation management, and shared decision-making should play an even more pronounced role in breast augmentations in trans women.
Level of evidence: Level III, risk/prognostic study.
Dietary fat intake and risk of disabling hearing impairment: a prospective population-based cohort study
Authors: Yévenes-Briones Humberto , Caballero Francisco Félix , Struijk Ellen A. , Lana Alberto , Rodríguez-Artalejo Fernando , Lopez-Garcia Esther 
Published: July 2021

Abstract
Purpose
To examine the associations of specific dietary fats with the risk of disabling hearing impairment in the UK Biobank study.

Methods
This cohort study investigated 105,592 participants (47,308 men and 58,284 women) aged ≥ 40 years. Participants completed a minimum of one valid 24-h recall (Oxford Web-Q). Dietary intake of total fatty acids, polyunsaturated fatty acids (PUFA), saturated fatty acids (SFA), and monounsaturated fatty acids (MUFA) was assessed at baseline. Functional auditory capacity was measured with a digit triplet test (DTT), and disabling hearing impairment was defined as a speech reception threshold in noise > − 3.5 dB in any physical exam performed during the follow-up.

Results
Over a median follow-up of 3.2 (SD: 2.1) years, 832 men and 872 women developed disabling hearing impairment. After adjustment for potential confounders, including lifestyles, exposure to high-intensity sounds, ototoxic medication and comorbidity, the hazard ratios (HRs), and 95% confidence interval (CI) of disabling hearing function, comparing extreme quintiles of intakes were 0.91 (0.71–1.17) for total fat, 1.09 (0.83–1.44) for PUFA, 0.85 (0.64–1.13) for SFA and 1.01 (0.74–1.36) for MUFA among men. Among women, HRs comparing extreme intakes were 0.98 (0.78–1.24) for total fat, 0.69 (0.53–0.91) for PUFA, 1.26 (0.96–1.65) for SFA, and 0.91 (0.68–1.23) for MUFA. Replacing 5% of energy intake from SFA with an equivalent energy from PUFA was associated with 25% risk reduction (HR: 0.75; 95% CI: 0.74–0.77) among women.

Conclusions
PUFA intake was associated with decreased risk of disabling hearing function in women, but not in men.
The categorical use of a continuous time representation
Authors: Beracci Alessia , Santiago Julio , Fabbri Marco 
Published: July 2021

AbstractThe abstract concept of time is mentally represented as a spatially oriented line, with the past associated with the left space and the future associated with the right. Although the line is supposed to be continuous, most available evidence is also consistent with a categorical representation that only discriminates between past and future. The aim of the present study was to test the continuous or categorical nature of the mental timeline. Italian participants judged the temporal reference of 20 temporal expressions by pressing keys on either the left or the right. In Experiment 1 (N = 32), all words were presented at the center of the screen. In Experiment 2 (N = 32), each word was presented on the screen in a central, left, or right position. In Experiment 3 (N = 32), all text was mirror-reversed. In all experiments, participants were asked to place the 20 temporal expressions on a 10-cm line. The results showed a clear Spatial–TEmporal Association of Response Codes (STEARC) effect which did not vary in strength depending on the location of the temporal expressions on the line. However, there was also a clear Distance effect: latencies were slower for words that were closer to the present than further away. We conclude that the mental timeline is a continuous representation that can be used in a categorical way when an explicit past vs. future discrimination is required by the task.
Patterns of airway obstruction of non-acquired origin in children with and without major congenital anomalies
Authors: Dias Rodrigo Gonçalves , Giger Roland , Latzin Philipp , Riva Thomas , Casaulta Carmen , Ulmer Francis , Jaquet Yves , Nisa Lluís 
Published: July 2021

AbstractMajor congenital anomalies are known to play a role in the management and prognosis of airway obstruction. Most studies assess acquired forms of airway obstruction. Data on congenital or otherwise non-acquired forms of airway obstruction is sparse. In this retrospective, single-institution cohort study, we sought to evaluate and compare the patterns of airway obstruction in children with and without major congenital anomalies, and to assess the impact of management and outcome, irrespective of aetiology. Fifty-five patients were included, 23 with and 32 without underlying major congenital anomalies. Multilevel airway obstruction (usually affecting the nasopharynx, oropharynx, and the trachea) was more common in children with congenital anomalies (91% vs. 41%, p < .001). Consequently, these children required more frequent and earlier surgical management, especially tracheostomy and adenotonsillar surgery.Conclusions: Major congenital anomalies are associated with multilevel airway obstruction and poor functional prognosis. A simple clinical definition considering impact of major congenital anomalies on development and growth may help guide management plans following endoscopic evaluation of the entire airway and flanked by multidisciplinary discussions.

What is Known:• Children with major comorbidities display increased disease severity and more prevalent multilevel airway obstruction• Previous studies include both children with acquired and non-acquired forms of airway obstruction; therefore, the actual impact major comorbidities in children with non-acquired causes of airway obstruction remain unclear.

What is New:• A total of 42% children in this study population had major comorbidities with and impact on growth and/or psychomotor development, with a higher prevalence of multilevel airway obstruction and worse rates of functional improvement/recovery.• Children with major comorbidities require tracheostomy more often and earlier than those without major comorbidities, and remain tracheostomy-dependent for a longer time.
Anti-tumour effect of neo-antigen-reactive T cells induced by RNA mutanome vaccine in mouse lung cancer
Authors: Sun Jiaxing , Zhang Jing , Hu Haiyan , Qin Huan , Liao Ximing , Wang Feilong , Zhang Wei , Yin Qi , Su Xiaoping , He Yanan , Li Wenfeng , Wang Kun , Li Qiang 
Published: July 2021

Abstract
Purpose
Mutation-specific T-cell response to epithelial cancers and T-cell-based immunotherapy has been successfully used to treat several human solid cancers. We aimed to investigate the anti-tumour effect of neo-antigen-reactive T(NRT) cells induced by RNA mutanome vaccine, which may serve as a feasible and effective therapeutic approach for lung cancer.

Methods
We predicted candidate neo-antigens according to the mutant gene analysis by sequencing the mouse Lewis cells and C57BL/6 mouse tail tissue. RNA vaccine was prepared with the neo-antigens as the template. We assessed antitumor efficacy, cytokine secretion and pathological changes after adoptive transfer of NRT cells in vitro and vivo experiments.

Results
We identified 10 non-synonymous somatic mutations and successfully generated NRT cells. The percentage of T-cell activation proportion was increased from 0.072% in conventional T cells to 9.96% in NRT cells. Interferon-γ secretion augmented from 17.8 to 24.2% as well. As an in vivo model, adoptive NRT cell infusion could promote active T-cell infiltration into the tumour tissue and could delay tumour progression.

Conclusion
NRT cells induced by RNA mutanome vaccine exert a significant anti-tumour effect in mouse lung cancer, and adoptive NRT cell therapy might be considered a feasible, effective therapeutic approach for lung cancer.
Greenhouse Gas Balance of Sphagnum Farming on Highly Decomposed Peat at Former Peat Extraction Sites
Authors: Oestmann Jan , Tiemeyer Bärbel , Düvel Dominik , Grobe Amanda , Dettmann Ullrich 
Published: July 2021

AbstractFor two years, we quantified the exchange of carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) at two different large-scale Sphagnum farming sites. At both, peat extraction left a shallow layer of highly decomposed peat and low hydraulic conductivities. One site was characterized by preceding multi-annual inundation and irrigated by ditches, while the other one was inoculated directly after peat extraction and irrigated by ditches and drip irrigation. Further, GHG emissions from an irrigation polder and the effect of harvesting Sphagnum donor material at a near-natural reference site were determined. GHG mitigation potentials lag behind the results of less decomposed sites, although our results were also affected by the extraordinary hot and dry summer 2018. CO2 exchanges ranged between -0.6 and 2.2 t CO2-C ha−1 y−1 and were mainly influenced by low water table depths. CH4 emissions were low with the exception of plots with higher Eriophorum covers, while fluctuating water tables and poorly developing plant covers led to considerable N2O emissions at the ditch irrigation site. The removal of the upper vegetation at the near-natural site resulted in increased CH4 emissions and, on average, lowered CO2 emissions. Overall, best plant growth and lowest GHG emissions were measured at the previously inundated site. At the other site, drip irrigation provided more favourable conditions than ditch irrigation. The size of the area needed for water management (ditches, polders) strongly affected the areal GHG balances. We conclude that Sphagnum farming on highly decomposed peat is possible but requires elaborate water management.
Corticosteroid injections in the temporomandibular joint temporarily alleviate pain and improve function in rheumatoid arthritis
Authors: Kroese Johanna Margaretha , Kopp Sigvard , Lobbezoo Frank , Alstergren Per 
Published: July 2021

AbstractObjectivesTo evaluate the effect of corticosteroid injections in the painful temporomandibular joint (TMJ) of patients with rheumatoid arthritis (RA) in relation to systemic inflammatory activity.MethodExamination of 35 patients (median age 54 years; 89% female) included maximum mouth opening capacity, degree of anterior open bite (AOB), TMJ pain intensity at rest, and crepitus. Serum levels of rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serotonin, and plasma levels of interleukine-1β (IL-1β) were determined. Out of the 70 examined joints, 53 joints received a corticosteroid (methylprednisolone) injection after the clinical examination at baseline (T0). The examination was repeated for all patients at T1 (median 3.1 weeks after T0), and for 21 patients at T2 (median 6.3 weeks after T1), of whom 20 patients received a second injection at T1.ResultsMaximum mouth opening capacity significantly increased, and TMJ pain intensity significantly decreased between T0 and T1, but these improvements were no longer present at T2. No differences were found in AOB between the time points. Of the joints that received an injection at T0, 19 joints had pretreatment crepitus, which resolved in eight joints at T1. No correlations were found between the change in mouth opening capacity or TMJ pain intensity and ESR, CRP, serotonin, or IL-1β.ConclusionsMethylprednisolone injections in the TMJ alleviate pain and improve mouth opening capacity for approximately 3 weeks, allowing patients to perform jaw exercises during this timeframe of temporary relief. It thus seems useful for the short-term management of TMJ involvement in RA.Key Points•In rheumatoid arthritis, corticosteroid injection in the temporomandibular joint alleviates pain and improves function.•The clinical improvement achieved with methylprednisolone injections lasts for approximately 3 weeks.•Corticosteroid injections could be used to facilitate and support additional noninvasive, conservative treatment options.
Saving energy in residential buildings: the role of energy pricing
Authors: Ewald Jens , Sterner Thomas , Ó Broin Eoin , Mata Érika 
Published: July 2021

AbstractA zero-carbon society requires dramatic change everywhere including in buildings, a large and politically sensitive sector. Technical possibilities exist but implementation is slow. Policies include many hard-to-evaluate regulations and may suffer from rebound mechanisms. We use dynamic econometric analysis of European macro data for the period 1990–2018 to systematically examine the importance of changes in energy prices and income on residential energy demand. We find a long-run price elasticity of −0.5. The total long-run income elasticity is around 0.9, but if we control for the increase in income that goes towards larger homes and other factors, the income elasticity is 0.2. These findings have practical implications for climate policy and the EU buildings and energy policy framework.
Paraneoplastic myelitis associated with durvalumab treatment for extensive-stage small cell lung cancer
Authors: Wang Lan , Lou Haiyan , Li Bo , Li Jun , Yang Yun-Mei 
Published: July 2021

SummaryParaneoplastic neurologic syndromes(PNSs) caused by immune checkpoint inhibitors(ICIs) is rare and requires clinicians to differentiate between disease progression and immune-related adverse effects(irAEs). We hereby report the case of immune-related myelitis accompanied by positive paraneoplastic autoantibodies following durvalumab treatment for extensive-stage small cell lung cancer (ES-SCLC). A 70-year-old Chinese woman with ES-SCLC was administered durvalumab with etoposid-platinum(EP) as first-line treatment. Four cycles after treatment with EP plus ICI, she developed immune-related myelitis with positive paraneoplastic autoantibodies (CV2, SOX1, ZIC4). Spinal MRI showed diffuse abnormal signal shadow in the cervicothoracic spinal cord. She was discontinued for chemotherapy, and treated with high-dose steroids, intravenous immunoglobulin and plasmapheresis, maintenance therapy with steroids resulted in a favorable neurologic outcome. This is the first report of durvalumab-related PNSs. We supposed that the development of paraneoplastic myelitis was causally related to immune activation by durvalumab. Prompt diagnosis and therapeutic intervention are essential for the effective treatment of paraneoplastic myelitis.
Transcatheter therapies for secondary mitral regurgitation in advanced heart failure: what are we aiming for?
Authors: Scotti Andrea , Munafò Andrea , Margonato Alberto , Godino Cosmo 
Published: July 2021

AbstractA severe secondary mitral regurgitation (SMR) can be found in a significant portion of patients affected by advanced heart failure (AHF). Conventional therapies (optimal medical therapy, devices, surgery) present restricted clinical efficacy in this stage of the left ventricle disease which is burdened by high mortality and morbidity rates. Although the treatment of choice is represented by heart transplantation (HTx), there is an unmet need related to the limited supply of donor hearts (as opposed to the growing prevalence of AHF) and the low eligibility of highly symptomatic patients. In case of concomitant severe SMR, transcatheter mitral valve therapies (repair and replacement) may play a crucial role in this setting. While a direct prognostic improvement after correction of SMR has yet to be proved, AHF patients can benefit from the following: hemodynamic stabilization, symptomatic relief, normalization of pulmonary arterial pressures, and reduction in hospitalizations for acute heart failure. Obtaining these results may lead to the clinical consequences of reaching the HTx in good enough clinical status (bridge to heart transplantation), becoming eligible for the HTx (bridge to HTx candidacy), and being delisted for clinical improvement (bridge to recovery). Therefore, achieving traditional secondary endpoints in patients with AHF and SMR can translate into significant clinical implications.
Multimodal Wearable Intelligence for Dementia Care in Healthcare 4.0: a Survey
Authors: Yang Po , Bi Gaoshan , Qi Jun , Wang Xulong , Yang Yun , Xu Lida 
Published: July 2021

AbstractAs a new revolution of Ubiquitous Computing and Internet of Things, multimodal wearable intelligence technique is rapidly becoming a new research topic in both academic and industrial fields. Owning to the rapid spread of wearable and mobile devices, this technique is evolving healthcare from traditional hub-based systems to more personalised healthcare systems. This trend is well-aligned with recent “Healthcare 4.0” which is a continuous process of transforming the entire healthcare value chain to be preventive, precise, predictive and personalised, with significant benefits to elder care. But empowering the utility of multimodal wearable intelligence technique for elderly care like people with dementia is significantly challenging considering many issues, such as shortage of cost-effective wearable sensors, heterogeneity of wearable devices connected, high demand for interoperability, etc. Focusing on these challenges, this paper gives a systematic review of advanced multimodal wearable intelligence technologies for dementia care in Healthcare 4.0. One framework is proposed for reviewing the current research of wearable intelligence, and key enabling technologies, major applications, and successful case studies in dementia care, and finally points out future research trends and challenges in Healthcare 4.0.
Adverse Selection, Heterogeneous Beliefs, and Evolutionary Learning
Authors: Buchen Clemens , Palermo Alberto 
Published: July 2021

AbstractWe relax the common assumption of homogeneous beliefs in principal-agent relationships with adverse selection. Principals are competitors in the product market and write contracts also on the base of an expected aggregate. The model is a version of a cobweb model. In an evolutionary learning set-up, which is imitative, principals can have different beliefs about the distribution of agents’ types in the population. The resulting nonlinear dynamic system is studied. Convergence to a uniform belief depends on the relative size of the bias in beliefs.
Osteonecrosis of the jaw: a rare but possible side effect in thyroid cancer patients treated with tyrosine-kinase inhibitors and bisphosphonates
Authors: Lorusso L. , Pieruzzi L. , Gabriele M. , Nisi M. , Viola D. , Molinaro E. , Bottici V. , Elisei R. , Agate L. 
Published: July 2021

AbstractOsteonecrosis of the jaw (ONJ) is a rare but very serious disease that can affect both jaws. It is defined as exposed bone in the maxillofacial region that does not heal within 8 weeks after a health care provider identification. ONJ can occur spontaneously or can be due to drugs like bisphosphonates (BPS) and anti-RANK agents, in patients with no history of external radiation therapy in the craniofacial region. Although in phase 3 trials of tyrosine kinase inhibitors (TKIs) used in thyroid cancer (TC) the ONJ was not reported among the most common side effects, several papers reported the association between ONJ and TKIs, both when they are used alone and in combination with a bisphosphonate. The appearance of an ONJ in a patient with metastatic radio-iodine refractory differentiated TC, treated with zoledronic acid and sorafenib, has put us in front of an important clinical challenge: when a ONJ occurred during TKIs treatment, it really worsens the patients’ quality of life. We should consider that in the case of ONJ a TKI discontinuation becomes necessary, and this could lead to a progression of neoplastic disease. The most important aim of this review is to aware the endocrinologists/oncologists dealing with TC to pay attention to this possible side effect of BPS and TKIs, especially when they are used in association. To significantly reduced the risk of ONJ, both preventive measures before initiating not only antiresorptive therapy but also antiangiogenic agents, and regular dental examinations during the treatment should always be proposed.
HatchEnsemble: an efficient and practical uncertainty quantification method for deep neural networks
Authors: Xia Yufeng , Zhang Jun , Jiang Tingsong , Gong Zhiqiang , Yao Wen , Feng Ling 
Published: July 2021

AbstractQuantifying predictive uncertainty in deep neural networks is a challenging and yet unsolved problem. Existing quantification approaches can be categorized into two lines. Bayesian methods provide a complete uncertainty quantification theory but are often not scalable to large-scale models. Along another line, non-Bayesian methods have good scalability and can quantify uncertainty with high quality. The most remarkable idea in this line is Deep Ensemble, but it is limited in practice due to its expensive computational cost. Thus, we propose HatchEnsemble to improve the efficiency and practicality of Deep Ensemble. The main idea is to use function-preserving transformations, ensuring HatchNets to inherit the knowledge learned by a single model called SeedNet. This process is called hatching, and HatchNet can be obtained by continuously widening the SeedNet. Based on our method, two different hatches are proposed, respectively, for ensembling the same and different architecture networks. To ensure the diversity of models, we also add random noises to parameters during hatching. Experiments on both clean and corrupted datasets show that HatchEnsemble can give a competitive prediction performance and better-calibrated uncertainty quantification in a shorter time compared with baselines.