bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced influence of ENSO on winter precipitation over southern China in recent decades
Authors: Zhang Ruhua , Tian Wenshou , He Xin , Qie Kai , Liu Di , Tian Hongying 
Published: July 2021

AbstractUsing observation, reanalysis and model datasets, the impact of the El Niño-Southern Oscillation (ENSO) on winter precipitation in southern China is re-examined. The results show that positive correlation between ENSO and winter precipitation in southern China after 1995 is significantly higher than that before 1995. Significant positive correlation is located mainly over the southern coastal areas of China before 1995, whereas the positive correlation extends northward to the Yangtze River basin after 1995. These changes in the relationship between ENSO and winter precipitation are related to the ENSO pattern and Philippine anticyclone changes. An increasing trend is observed in the ENSO amplitude, while the area with cooler SST in the Philippine seas extends westward after 1995 compared with that before 1995, leading to an extension of the anticyclone from the east side to the west side of the Philippines. The westward extension of anticyclone after 1995 could enhance the winter precipitation over southern China through modifying water vapour fluxes and vertical motion. Model results support the observation analyses of the changes in ENSO-precipitation relationship and the corresponding mechanism. The mean SST changes could also modify the ENSO-precipitation relationship.
Laboratory experiments on CO2 gas exchange with wave breaking
Authors: Li Shuo , Babanin Alexander V. , Qiao Fangli , Dai Dejun , Jiang Shumin , Guan Changlong 
Published: July 2021

AbstractTheCO2gas transfer velocity () at air-sea interface is usually parameterized with the wind speed, but to a great extent is defined by waves and wave breaking. To investigate the direct relationship betweenand waves, laboratory experiments are conducted in a wind-wave flume. Three types of waves are forced in the flume: modulational wave trains generated by a wave maker, wind waves with 10-meter wind speed ranging from 4.5 m/s to 15.5 m/s, and (mechanically-generated) modulational wave trains coupled with superimposed wind force. The wave height and wave orbital velocity are found to be well correlated withwhile wind speed alone can not adequately describe. To reconcile the measurements, non-dimensional equations are established in which gas transfer velocity is expressed as a main function of wave parameters and an additional secondary factor to account for influence of the wind.
The CHA2DS2-VASc Risk Score Predicts Total Occlusion in Infarct-Related Arteries in Patients With Non-ST Elevation Myocardial Infarction
Authors: Yaşar Erdoğan , Bayramoğlu Adil , Karakuş Yasin , Çakmak Tolga 
Published: July 2021

Early detection of total coronary artery occlusion (TO) in non-ST elevation myocardial infarction (NSTEMI) patients may be beneficial since invasive treatments are initiated more rapidly in appropriate patients. Previous studies have shown that the CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, previous stroke, vascular disease, age between 65 and 74 years, female gender) score is associated with thrombus burden in acute coronary syndromes. We investigated the association between the CHA2DS2-VASc risk score and TO in patients with NSTEMI who underwent coronary angiography. TIMI (thrombolysis in myocardial infarction) flow 0 was defined as TO and TIMI flow 1-3 was defined as non-total occlusion (non-TO). The NSTEMI patients (n = 400) included were separated into two groups: those with (n = 138) and without (n = 262) TO. We observed that the CHA2DS2-VASc score was higher in the TO group (3.86 ± 2.32 vs 2.15 ± 1.79, P <.001). The Global Registry of Acute Coronary Events (GRACE) score ( P = .002) and the CHA2DS2-VASc score ( P < .001) were also found to be significant independent predictors for total occlusion in multiple regression analysis. A CHA2DS2-VASc score ≥3 had 68.1% sensitivity and 64.0% specificity (area under the curve (AUC): 0.657, 95% CI: 0.585-0.725, P < .001) for predicting TO. The CHA2DS2-VASc score was an effective tool that predicted TO in patients with NSTEMI.
Airway Management of the Deformed Trachea Using T-Tube Stents in Patients with Mucopolysaccharidosis Type IVA
Authors: Lee Yi-Hao , Hsieh Li-Chun , Su Chin-Hui , Lin Hsiang-Yu , Lin Shuan-Pei , Lee Kuo-Sheng 
Published: July 2021

Introduction: Mucopolysaccharidosis (MPS) type IVA usually results in airway obstruction due to thoracic cage deformity and crowding of intrathoracic structures, causing tracheal compression by the tortuous innominate artery. Objectives: To offer an alternative and effective method in dealing with the challenged deformity of the airway in patients with MPS type IVA. Methods: We present 3 patients with MPS type IVA who underwent airway stenting using Montgomery® T-tube stents. Three-dimensional reconstructed computed tomography was essential to design the T-tube and evaluate the anatomical relationship between the innominate artery and the trachea. The Y-shaped Montgomery® Pediatric Safe-T-Tube™ is more suitable for MPS type IVA. Regular follow-ups using fiberoptic bronchoscopy are necessary to evaluate the complications. Results: All 3 patients had good outcomes during the follow-ups until present, despite the complication of granulation formation, which was resolved by revising the limbs of the T-tube. Conclusions: T-tube stents placed below the vocal cord may restore airway patency and preserve laryngeal function, including respiration, phonation, and swallowing, in patients with MPS type IVA.
Isoginkgetin treatment attenuated lipopolysaccharide-induced monoamine neurotransmitter deficiency and depression-like behaviors through downregulating p38/NF-κB signaling pathway and suppressing microglia-induced apoptosis
Authors: Li Peng , Zhang Fucheng , Li Yajuan , Zhang Cai , Yang Zhiyou , Zhang Yongping , Song Cai 
Published: July 2021

Background: Microglia activation-induced neuroinflammation may contribute to the etiology of depression. Podocarpus nagi containing high concentration of isoginkgetin could effectively treat mental diseases in ancient times. However, the therapeutic role, peculiarly in the brain–immune modulation in depression is still unclear. This study aimed to determine effects of isoginkgetin on lipopolysaccharide (LPS)-induced depression-like changes. Furthermore, its modulation on the p38/nuclear factor-kappa B (NF-κB) pathway in LPS-activated microglia was evaluated. Methods: Adult Kunming mice were intraperitoneally injected vehicle or isoginkgetin (4 mg/kg) daily for 14 days before saline or LPS (0.83 mg/kg) administration. Depression-like behavior, neurotransmitter levels, and markers of neuroinflammation were determined. Isoginkgetin effect on LPS-induced microglial activation was then assessed in BV2 cells. Finally, conditioned medium (CM) derived from isoginkgetin-treated BV2 cells was co-cultured with SH-SY5Y cells for 24 h. Cell viability and apoptosis were evaluated. Results: LPS significantly induced helplessness and anxiety, which were associated with decreased 5-HT, noradrenaline, and dopamine concentrations. Meanwhile, LPS increased microglia M1 hallmark Iba1 expression and serum interleukin (IL)-1β concentration. These changes were attenuated by isoginkgetin treatment. In vitro, isoginkgetin markedly suppressed the production of IL-1β, IL-6, tumor necrosis factor-alpha, cyclooxygenase-2, inducible nitric oxide, and reactive oxygen species, which are released from LPS-stimulated BV2 cells. More interestingly, CM from isoginkgetin-treated BV2 cells significantly alleviated SH-SY5Y cell apoptosis and restored cell viability compared to LPS-treated group through the inhibition of p38/NF-κB signaling pathway. Conclusion: These data demonstrate that isoginkgetin is an effective therapeutic agent for depression-like behaviors and neuropathological changes via potent anti-inflammatory property.
The association between sensory traits and daily parenting challenges of typical mothers and their children
Authors: Gafni-Lachter Liat , Kailkian Joanna , Korngold-Dvir Vered , Dahan Gil , Ben-Sasson Ayelet 
Published: July 2021

Introduction Sensory modulation impacts daily family life; however, parents’ sensory traits are rarely considered and analysed together with their child’s. This study aimed to: (1) determine the association between healthy child and mother sensory modulation traits and (2) examine how these traits interact in predicting daily parenting challenges. Method Seventy-three healthy mothers of typically developing 3–6-year-old children completed the Short Sensory Profile, Adult/Adolescent Sensory Profile and Parenting Daily Hassles questionnaires. Mother and child sensory over-responsivity (SOR), under-responsivity (SUR) and seeking traits were entered as predictors of frequency of daily hassles. Results Mother and child’s SOR and SUR traits were significantly associated ( r = .33 and .25, respectively). The frequency of parenting challenges was significantly associated with both mother and child’s sensory seeking ( r = .25 and .26, respectively). A mediation model demonstrated a significant indirect effect of mother SOR on the frequency of daily hassles ( β = .26, p < .05), with the child’s SOR ( β = .33, p < .01), and seeking behaviours ( β = .48, p < .001) mediating this effect. Conclusion Mothers with elevated sensory traits of children with elevated sensory traits are likely to experience higher frequencies of daily parenting burden, even within the typical population. Therapists who wish to practice a developmental and family-centred approach should assess how the mother–child sensory traits interact and how this interaction can influence the family’s well-being.
Physical and emotional development of adolescents with low motor competence: Mothers’ perspectives
Authors: Timler Amanda , Bulsara Caroline , Hands Beth 
Published: July 2021

Background Parent support influences adolescent’s social-emotional well-being. One factor that may influence parent’s perception of support is their child’s level of motor competence. Aim The purpose of this study was to explore mothers’ experience of providing support for the health of adolescents with low motor competence physical and emotional development. Methods A phenomenological approach was used to guide this study. After initial screening, five one-on-one interviews with mothers of adolescents aged 12–16 years were conducted. Results Analysis of the interviews identified five themes of ‘supportive building blocks’, ‘building achievement and commitment,’ ‘building mechanisms for future support’ ‘building stability in relationships’ and ‘building confidence and a sense of autonomy’. Mother’s awareness of their child’s motor difficulties resulted in their active provision of alternative strategies for their child by building self-confidence and seeking support from health professionals. Conclusion Mothers were aware of their child’s inadequacies and actively sought support to help with their development. Support services that recognise low motor competence could better help mothers support their adolescent’s development. One implication arising from this study is the importance of using multi-disciplinarian teams such as occupational therapist, exercise physiologist and parents to help children with low motor competence.
Compassion fatigue as bruises in the soul: A qualitative study on nurses
Authors: Gustafsson Tove , Hemberg Jessica 
Published: July 2021

Background: Nurses who are constantly being exposed to patients’ suffering can lead to compassion fatigue. There is a gap in the latest research regarding nurses’ experiences of compassion fatigue. Little is known about how compassion fatigue affects the nurse as a person, and indications of how it affects the profession are scarce. Aim: The aim of this study was to explore compassion fatigue experienced by nurses and how it affects them as persons and professionals. Research design, participants, and research context: A qualitative explorative approach was used. The data consisted of texts from interviews with seven nurses in various nursing contexts. Content analysis was used. Ethical consideration: Ethical approval was sought and granted from an ethics committee at the university where the researchers were based, and written, informed consent was obtained from all the participants. Findings: Five themes were discovered: Compassion as an empathic gift and compassion fatigue as a result of compassion overload, Compassion fatigue as exhausting the nurse as a professional and private person, Compassion fatigue as a crisis with potentially valuable insights, Compassion fatigue can be handled by self-care and focus on self, and Compassion fatigue is affected by life itself and multifaceted factors. Discussion: Compassion stress and overload can lead to compassion fatigue. Compassion fatigue affects the nurse’s ability to compassion, and the caring is no longer experienced in the same way; the nurses experienced it as being deprived of the gift of compassion. Compassion fatigue implicates a crisis with potentially valuable insights. Conclusion: Compassion fatigue can be symbolized as bruises in the soul, hurtful, but with time it can fade away, although it leaves a sense of caution within the nurse, which can affect the suffering patient.
Association Between Potentially Inappropriate Medications and 30-Day Post–Hospital Discharge Outcomes in US Veterans
Authors: Allore Heather G. , Gnjidic Danijela , Skanderson Melissa , Han Ling 
Published: July 2021

Background Potentially inappropriate medication (PIMs) use is common in older inpatients and it may lead to increased risk of adverse drug events. Objectives To examine prevalence of PIMs at hospital discharge and its contribution to health care utilization and mortality within 30-days of hospital discharge. Methods This was a prospective cohort of 117 570 veterans aged ≥65 years and hospitalized in 2013. PIMs at discharge were categorized into central nervous system acting (CNS) and non-CNS. Outcomes within 30-days of hospital discharge were: (1) time to first acute care hospital readmission, and all-cause mortality, (2) an emergency room visit, and (3) ≥3 primary care clinic visits. Results The cohort’s mean age was 74.3 years (SD 8.1), with 51.3% exposed to CNS and 62.8% to non-CNS PIMs. Use of CNS and non-CNS PIMs, respectively, was associated with a reduced risk of readmission, with an adjusted hazard ratio (aHR) of 0.93 (95% CI = 0.89-0.96) for ≥2 (vs 0) CNS PIMs and an aHR of 0.85 (95% CI = 0.82-0.88) for ≥2 (vs 0) non-CNS PIMs. Use of CNS PIMs (≥2 vs 0) was associated with increased risk of mortality (aHR = 1.37 [95% CI = 1.25-1.51]), whereas non-CNS PIMs use was associated with a reduced risk of mortality (aHR = 0.75 [95% CI = 0.69-0.82]). Conclusion and Relevance PIMs were highly common in this veteran cohort, and the association with outcomes differed by PIMs. Thus, it is important to consider whether PIMs are CNS acting to optimize short-term posthospitalization outcomes.
Underreported Risk of Lisinopril-Induced Angioedema in a Veteran Population
Authors: Whitehead Whitley J. , Reid Jennifer Meyer 
Published: July 2021

Background: Lisinopril-induced angioedema (LIA) is a rare but serious adverse drug event (ADE) with a published incidence of 0.1% to 0.7%. It is well known that ADEs are widely underreported; however, LIA is one of the most reported ADEs within the Veterans Health Administration (VHA). Objective: To estimate the effect of underreporting on the risk of LIA within VHA. Methods: The reported risk of LIA was calculated from reports submitted to the Veterans Affairs (VA) Adverse Drug Event Reporting System (VA ADERS) and the number of veterans prescribed lisinopril. To estimate underreporting, local chart review identified cases of LIA that were compared to reports submitted. The underreporting rate was then applied to the national reported risk. Results: Locally, 68 reports of LIA were submitted of the 21 262 patients prescribed lisinopril, for a reported risk of 0.32%. Nationwide, 14 289 reports of LIA were submitted of the 3 109 661 patients prescribed lisinopril, for a crude reported risk of 0.46%. Of the 324 patients identified for chart review, 240 patients were diagnosed with LIA, suggesting that at least 71.7% of cases were unreported. When this underreporting rate is extrapolated to the national reported risk, a better estimate of the risk of LIA within VHA could increase to 1.6%. Conclusion and Relevance: When estimating the effect of underreporting, the risk of LIA increases to approximately 1.6% or 1 in 63 patients. Because this ADE may affect more patients than previously understood, providers may wish to take LIA into consideration when prescribing lisinopril.
Comparison of Risk Factors of Falling for Psychiatric Inpatients and General Ward Inpatients Who Had Fallen
Authors: Chang Wen P. , Jen Hsiu J. 
Published: July 2021

Background: For psychiatric patients, the issue of falling is complex. Aim: The objective of this study was to compare the risk factors for falling in psychiatric inpatients and general ward inpatients who had fallen. Methods: The researchers first derived official fall records for 122 psychiatric inpatients and then selected 122 psychiatric inpatients who had not fallen as well as 122 general ward patients who had fallen, matched for gender, age, and length of hospital stay at the time of the fall incident. Results: After controlling other variables, multinomial logistic regression analysis revealed that psychiatric inpatients who had fallen and had dizziness (odds ratio [OR] = 7.11, p < .001), had an unsteady gait (OR = 1.97, p = .030), or were not using aids (OR = 0.42, p = .042) were at greater risk of falling than those who had not fallen. The researchers also found that general ward inpatients who had fallen and had higher Charlson Comorbidity Index scores (OR = 1.77, p < .001), were clear-headed (OR = 27.15, p = .001), had dizziness (OR = 11.55, p < .001), were unable to walk (OR = 64.28, p < .001), or were using aids (OR = 3.86, p = .001) were at greater risk of falling than those who had not fallen before. Conclusions: The causes of falling among psychiatric inpatients and general ward inpatients are different. Medical personnel should understand the medications and attributes of patients for an accurate assessment of their risk factors for falling and thus implement fall prevention measures and health education to reduce falls.
Ultrasound evaluation of dialysis access-related distal ischaemia
Authors: Pirozzi N , De Alexandris L , Scrivano J , Fazzari L , Malik J 
Published: July 2021

Dialysis access-related distal ischaemia is a rare yet potentially rather risky complication of haemodialysis angioaccess. Timely diagnosis is crucial to target both the goals of the access team: first of all to preserve the function of the hand ideally along with angioaccess patency. Unfortunately for some patients, urgent access ligation and central vein catheter insertion would be needed to save the hand. After a first clinical examination to determine the diagnostic suspicion, the ultrasound evaluation would provide nearly all the needed information to confirm the diagnosis and to determine the most appropriate procedure to rescue the patient from distal ischaemia. In some cases, photoplethysmography would help in the differential diagnosis of other non-ischaemic causes of similar signs and symptoms. Angiography would complete the preoperative evaluation for some. Dialysis access-related distal ischaemia would be briefly reviewed, and a deep description of the ultrasound examination tools and findings would be provided for a tailored therapeutic approach.
Health system barriers to accessing care for children with weight issues in New Zealand: An interview-based study
Authors: Wild Cervantée EK , Rawiri Ngauru , Willing Esther J , Hofman Paul L , Anderson Yvonne C 
Published: July 2021

Objective To identify barriers created and maintained by the health system affecting engagement in a family-based multidisciplinary healthy lifestyle programme for children and adolescents in New Zealand. Methods We conducted 64 semi-structured interviews with participants of the programme (n = 71) with varying levels of engagement, including those who declined contact after their referral. Half the interviews were with families with Māori children, allowing for appropriate representation. Interviews were analysed using thematic analysis. Results Five health system factors affecting engagement were identified: the national policy environment, funding constraints, lack of coordination between services, difficulty navigating the health system, and the cost of primary health care. Conclusions Engaging with a health system that creates and maintains substantial barriers to accessing services is difficult, affecting programme engagement, even where service-level barriers have been minimised. Lack of access remains a crucial barrier to improved health outcomes for children and their families experiencing childhood obesity in New Zealand. There is a need for comprehensive approaches that are accompanied by a clear implementation strategy and coordinated across sectors.
Siblings of young people with chronic illness: Caring responsibilities and psychosocial functioning
Authors: Kelada Lauren , Wakefield Claire E , Drew Donna , Ooi Chee Y. , Palmer Elizabeth E , Bye Ann , De Marchi Sandra , Jaffe Adam , Kennedy Sean 
Published: July 2021

Siblings of young people with chronic illness commonly undertake caring responsibilities for their affected brother/sister, which may encourage maturation, yet may also be perceived as a burden. Our study determined (1) siblings’ caring responsibilities, (2) siblings’ current emotional distress and psychosocial functioning, and (3) how siblings’ caring responsibilities and psychosocial functioning related to familial relationships and coping strategies. Siblings completed questionnaires which contained Sibling Inventory of Behavior, Sibling Inventory of Differential Experiences, PedsQL, emotion thermometers, Brief COPE, and a checklist of caregiving responsibilities. We analyzed the data with t-tests and multi-level models. Forty-five siblings (mean age = 15.40 years, SD = 3.31 years; 60.0% female) participated. Siblings who had caring responsibilities ( n = 26, 57.8%) reported lower anxiety symptoms, lower need for help, greater use of problem-focused coping, and more companionship and teaching/directiveness with their affected brother/sister than siblings without caring responsibilities. Siblings reported lower psychosocial and physical functioning when they perceived their parents provided them with less affection than their affected brother/sister. Family-based psychosocial interventions may aim to improve the sibling–parent relationship (including expressing affection) and the sibling–sibling relationship. Future interventions may also focus on increasing siblings’ use of problem-focused coping strategies.