bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing and Identifying the Prevalence of Web-Based Misinformation Relating to Medication for Opioid Use Disorder: Machine Learning Approach
Authors: ElSherief Mai , Sumner Steven A , Jones Christopher M , Law Royal K , Kacha-Ochana Akadia , Shieber Lyna , Cordier LeShaundra , Holton Kelly , De Choudhury Munmun 
Published: December 2021

Background
Expanding access to and use of medication for opioid use disorder (MOUD) is a key component of overdose prevention. An important barrier to the uptake of MOUD is exposure to inaccurate and potentially harmful health misinformation on social media or web-based forums where individuals commonly seek information. There is a significant need to devise computational techniques to describe the prevalence of web-based health misinformation related to MOUD to facilitate mitigation efforts.

Objective
By adopting a multidisciplinary, mixed methods strategy, this paper aims to present machine learning and natural language analysis approaches to identify the characteristics and prevalence of web-based misinformation related to MOUD to inform future prevention, treatment, and response efforts.

Methods
The team harnessed public social media posts and comments in the English language from Twitter (6,365,245 posts), YouTube (99,386 posts), Reddit (13,483,419 posts), and Drugs-Forum (5549 posts). Leveraging public health expert annotations on a sample of 2400 of these social media posts that were found to be semantically most similar to a variety of prevailing opioid use disorder–related myths based on representational learning, the team developed a supervised machine learning classifier. This classifier identified whether a post’s language promoted one of the leading myths challenging addiction treatment: that the use of agonist therapy for MOUD is simply replacing one drug with another. Platform-level prevalence was calculated thereafter by machine labeling all unannotated posts with the classifier and noting the proportion of myth-indicative posts over all posts.

Results
Our results demonstrate promise in identifying social media postings that center on treatment myths about opioid use disorder with an accuracy of 91% and an area under the curve of 0.9, including how these discussions vary across platforms in terms of prevalence and linguistic characteristics, with the lowest prevalence on web-based health communities such as Reddit and Drugs-Forum and the highest on Twitter. Specifically, the prevalence of the stated MOUD myth ranged from 0.4% on web-based health communities to 0.9% on Twitter.

Conclusions
This work provides one of the first large-scale assessments of a key MOUD-related myth across multiple social media platforms and highlights the feasibility and importance of ongoing assessment of health misinformation related to addiction treatment.
Development and Application of an Open Tool for Sharing and Analyzing Integrated Clinical and Environmental Exposures Data: Asthma Use Case
Authors: Fecho Karamarie , Ahalt Stanley C , Appold Stephen , Arunachalam Saravanan , Pfaff Emily , Stillwell Lisa , Valencia Alejandro , Xu Hao , Peden David B 
Published: December 2021

Background
The Integrated Clinical and Environmental Exposures Service (ICEES) serves as an open-source, disease-agnostic, regulatory-compliant framework and approach for openly exposing and exploring clinical data that have been integrated at the patient level with a variety of environmental exposures data. ICEES is equipped with tools to support basic statistical exploration of the integrated data in a completely open manner.

Objective
This study aims to further develop and apply ICEES as a novel tool for openly exposing and exploring integrated clinical and environmental data. We focus on an asthma use case.

Methods
We queried the ICEES open application programming interface (OpenAPI) using a functionality that supports chi-square tests between feature variables and a primary outcome measure, with a Bonferroni correction for multiple comparisons (α=.001). We focused on 2 primary outcomes that are indicative of asthma exacerbations: annual emergency department (ED) or inpatient visits for respiratory issues; and annual prescriptions for prednisone.

Results
Of the 157,410 patients within the asthma cohort, 26,332 (16.73%) had 1 or more annual ED or inpatient visits for respiratory issues, and 17,056 (10.84%) had 1 or more annual prescriptions for prednisone. We found that close proximity to a major roadway or highway, exposure to high levels of particulate matter ≤2.5 μm (PM2.5) or ozone, female sex, Caucasian race, low residential density, lack of health insurance, and low household income were significantly associated with asthma exacerbations (P<.001). Asthma exacerbations did not vary by rural versus urban residence. Moreover, the results were largely consistent across outcome measures.

Conclusions
Our results demonstrate that the open-source ICEES can be used to replicate and extend published findings on factors that influence asthma exacerbations. As a disease-agnostic, open-source approach for integrating, exposing, and exploring patient-level clinical and environmental exposures data, we believe that ICEES will have broad adoption by other institutions and application in environmental health and other biomedical fields.
Investigating the Implementation of SMS and Mobile Messaging in Population Screening (the SIPS Study): Protocol for a Delphi Study
Authors: Acharya Amish , Judah Gaby , Ashrafian Hutan , Sounderajah Viknesh , Johnstone-Waddell Nick , Stevenson Anne , Darzi Ara 
Published: December 2021

Background
The use of mobile messaging, including SMS, and web-based messaging in health care has grown significantly. Using messaging to facilitate patient communication has been advocated in several circumstances, including population screening. These programs, however, pose unique challenges to mobile communication, as messaging is often sent from a central hub to a diverse population with differing needs. Despite this, there is a paucity of robust frameworks to guide implementation.

Objective
The aim of this protocol is to describe the methods that will be used to develop a guide for the principles of use of mobile messaging for population screening programs in England.

Methods
This modified Delphi study will be conducted in two parts: evidence synthesis and consensus generation. The former will include a review of literature published from January 1, 2000, to October 1, 2021. This will elicit key themes to inform an online scoping questionnaire posed to a group of experts from academia, clinical medicine, industry, and public health. Thematic analysis of free-text responses by two independent authors will elicit items to be used during consensus generation. Patient and Public Involvement and Engagement groups will be convened to ensure that a comprehensive item list is generated that represents the public’s perspective. Each item will then be anonymously voted on by experts as to its importance and feasibility of implementation in screening during three rounds of a Delphi process. Consensus will be defined a priori at 70%, with items considered important and feasible being eligible for inclusion in the final recommendation. A list of desirable items (ie, important but not currently feasible) will be developed to guide future work.

Results
The Institutional Review Board at Imperial College London has granted ethical approval for this study (reference 20IC6088). Results are expected to involve a list of recommendations to screening services, with findings being made available to screening services through Public Health England. This study will, thus, provide a formal guideline for the use of mobile messaging in screening services and will provide future directions in this field.

Conclusions
The use of mobile messaging has grown significantly across health care services, especially given the COVID-19 pandemic, but its implementation in screening programs remains challenging. This modified Delphi approach with leading experts will provide invaluable insights into facilitating the incorporation of messaging into these programs and will create awareness of future developments in this area.

International Registered Report Identifier (IRRID)
PRR1-10.2196/32660
Neutralization of SARS-CoV-2 Variants of Concern in Kidney Transplant Recipients after Standard COVID-19 Vaccination
Authors: Benning Louise , Morath Christian , Bartenschlager Marie , Nusshag Christian , Kälble Florian , Buylaert Mirabel , Schaier Matthias , Beimler Jörg , Klein Katrin , Grenz Julia , Reichel Paula , Hidmark Asa , Ponath Gerald , Töllner Maximilian , Reineke Marvin , Rieger Susanne , Tönshoff Burkhard , Schnitzler Paul , Zeier Martin , Süsal Caner , Bartenschlager Ralf , Speer Claudius 
Published: December 2021

Background and objectives
Antibody response after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is impaired in kidney transplant recipients. Emerging variants, such as B.1.617.2 (δ), are of particular concern because of their higher transmissibility and partial immune escape. Little is known about protection against these variants in immunocompromised patients.

Design, setting, participants, & measurements
In this prospective two-center study, antispike 1 IgG and surrogate neutralizing antibodies were measured in 173 kidney transplant recipients and 166 healthy controls with different vaccination schedules. In addition, different SARS-CoV-2 epitope antibodies from 135 vaccinated kidney transplant recipients were compared with antibodies in 25 matched healthy controls after second vaccination. In 36 kidney transplant recipients with seroconversion, neutralization against B.1.1.7 (α), B.1.351 (β), and B.1.617.2 (δ) was determined on VeroE6 cells and compared with neutralization in 25 healthy controls.

Results
Kidney transplant recipients had significantly lower seroconversion rates compared with healthy controls. After the second vaccination, antispike 1, antireceptor-binding domain, and surrogate neutralizing antibodies were detectable in 30%, 27%, and 24% of kidney transplant recipients, respectively. This compares with 100%, 96%, and 100% in healthy controls, respectively (P<0.001). Neutralization against B.1.1.7 was detectable in all kidney transplant recipients with seroconversion, with a median serum dilution that reduces infection of cells by 50% of 80 (interquartile range, 80–320). In contrast, only 23 of 36 (64%) and 24 of 36 (67%) kidney transplant recipients showed neutralization against B.1.351 and B.1.617.2, respectively, with median serum dilutions that reduce infection of cells by 50% of 20 (interquartile range, 0–40) and 20 (interquartile range, 0–40), respectively. Neutralization against different variants was significantly higher in healthy controls (P<0.001), with all patients showing neutralization against all tested variants.

Conclusions
Seroconverted kidney transplant recipients show impaired neutralization against emerging variants of concern after standard two-dose vaccination.

Clinical Trial registry name and registration number:
Observational study to assess the SARS-CoV-2 specific immune response in kidney transplant recipients (COVID-19 related immune response), DRKS00024668
Situasi Filariasis Limfatik di Daerah Pasca Pemberian Obat Pencegahan Massal (POPM) dan Pasca Eliminasi di Kabupaten Tanjung Jabung Timur dan Belitung
Authors: Santoso Santoso , Yahya Yahya , Supranelfy Yanelza , Wurisastuti Tri 
Published: December 2021

East Tanjung Jabung Regency, Jambi did not pass in the Pre-Transmission Assessment Survey (Pre-TAS) in 2017, while Belitung, Bangka Belitung has a microfilaria rate (Mf rate) >1% even though it has passed TAS 1,2, and 3. The purpose of this study is to identify the program implementation control of lymphatic filariasis in East Tanjung Jabung Regency and Belitung Regency. The research was conducted in four villages, namely of Rantau Rasau 2, Nibung Putih (East Tanjung Jabung), Lasar, and Suak Gual (Belitung). Blood sampling was conducted on 1,919 people aged 5-70 years, while interviews were conducted on 900 people aged >16 years. The results of blood tests in East Tanjung Jabung were not found positive for mf, while in Belitung, 33 people were found positive for mf. The results of the risk estimate analysis of the respondent's knowledge, attitude and behavior factors indicate that respondents who live in East Tanjung Jabung Regency have a better level of knowledge, attitudes, and behaviour towards lymphatic filariasis t han respondents who live in Belitung Regency. Keywords: lymphatic filariasis, elimination, risk factor
Abstrak Kabupaten Tanjung Jabung Timur, Jambi tidak lulus dalam Survei Penilaian Pra Transmisi (Pre-TAS) tahun 2017, sedangkan Belitung, Bangka Belitung memiliki angka mikrofilaria (Mf rate) >1% padahal sudah lolos TAS 1,2, dan 3. Tujuan penelitian ini adalah untuk mengidentifikasi pelaksanaan program pengendalian penyakit filariasis limfatik di Kabupaten Tanjung Jabung Timur dan Kabupaten Belitung. Penelitian dilakukan di empat desa, yaitu Rantau Rasau, Nibung Putih (Tanjung Jabung Timur), Lasar dan Suak Gual (Belitung). Pengambilan sampel darah dilakukan pada 1.919 orang berusia 5-70 tahun, sedangkan wawancara dilakukan pada 900 orang berusia >16 tahun. Hasil tes darah di Tanjung Jabung Timur tidak ditemukan positif mf, sedangkan di Belitung, 33 orang ditemukan positif mf. Hasil analisis estimasi risiko faktor pengetahuan, sikap dan perilaku responden menunjukkan bahwa responden yang berdomisili di Kabupaten Tanjung Jabung Timur memiliki tingkat pengetahuan, sikap, dan perilaku yang lebih baik terhadap filariasis limfatik dibandingkan responden yang berdomisili di Kabupaten Belitung. Kata kunci: filariasis limfatik, eliminasi, faktor risiko
Videoobservasjoner og videobaserte samtaler som metoder for kvalitetsutvikling av barnehageansattes spesialpedagogiske praksis
Authors: Hanssen Natallia B. , Krogtoft Marit 
Published: December 2021

In Norway, there has been an increasing focus on the importance of the quality of early childhood education and care (ECEC). Several challenges have been identified, including significant criticism of the quality, validity and usability of special educational needs (SEN) practices. This primarily means that kindergarten employees do not seem to be aware of their practices and how their practices can be developed and improved.
The research question in this chapter is how video observation and video-based conversations can contribute to developing the quality of employees’ special educational needs practices in kindergarten. The theoretical part of the chapter is based on various approaches, but Jakob Meløe’s concept of the ‘aware gaze’ is the main inspiration.
The data were gathered through video observations and video-based conversations, and the chapter presents two kindergarten employees’ SEN practices. Using video-based conversation, they were able to reflect upon and aquire new knowledge relating to their own practice. The results show that it may help to consider inspiring kindergarten employees to use video observation and video-based conversation as meaningful tools to help employees reflect upon their own experiences and practices, thus contributing to the development of high-quality kindergartens.
Gênero e sexualidade em histórias de vida de mulheres do tráfico
Authors: Lima Marina Torres Costa , Velôso Thelma Maria Grisi , Santiago Idalina Maria Freitas Lima 
Published: December 2021

O artigo objetiva identificar, nas narrativas de histórias de vida de mulheres envolvidas com o tráfico de drogas e privadas de liberdade, as rupturas e as permanências com o discurso heteronormativo de gênero e sexualidade. Realizou-se uma pesquisa qualitativa e obtiveram-se oito entrevistas de história de vida que foram submetidas à análise de discurso. As narrativas são construídas nas múltiplas posições assumidas, ora no campo das continuidades, ora das descontinuidades, especialmente em relação às normas de gênero. A permanência das narradoras nas construções hegemônicas de gênero precisa ser pensada devido à força dos discursos que regulam e produzem os gêneros, cujos efeitos remontam à “naturalização” de comportamentos que fundamentam inúmeras relações de poder em sociedade.
THE EMPLOYEES' PERCEPTIONS OF LEARNING ENGLISH IN A BUSINESS CONTEXT
Authors: Suningsih Sri 
Published: December 2021

This study aims to investigate how the English is used in the business workplace.. The researcher used a quantitative and descriptive qualitative method. The data used in this study are from open-ended questionnaire to the employees working in economics and business. The result reflects the workers’ learning experiences while learning English in the colleges show the several topic discussion they learnt such as Introduction, and general English, the topics about finance/ accounting material and financial reports, venture capital, stocks and bonds, which are usually useful when meetings with foreign principals or other employees and their supervisor, Writing, reading, discussion, communication, Vocabularies, Determination of the stock price index, Management, recruitment, accounting, financial statement, Learnt accounting using English books and also learnt about English conversation its very useful for my work, Vocabularies about accounts related to financial statements. In addition, another participant responded that English that is learned on campus and at work is very different. Not all English skills are applied in the respondent's workplace, only reading is used most often. In term of English needs in the workplace, the professionals need Speaking skills and English language terms according to work fields.
THE CORRELATION BETWEEN GRAMMAR COMPETENCY AND SPEAKING ABILITY OF THE EIGHTH GRADE STUDENTS IN SMPN 1 PALU
Authors: Saputra Aldi , Nurasmawati  , Yuni Amelia  
Published: December 2021

This research was motivated by the problems experienced by some of the eighth grade students in SMPN 1 Palu. The students still had some difficulties when expressing their ideas or feelings by using English. They had various reasons for this. Most of them said that grammar is one of the causes of their difficulties in speaking English.
This research was a correlational design, the technique of collecting data using test. There were two kinds of test such as written test and oral test as the research instrument. The written test was used to measure students’ grammar competency and oral test was used to measure students’ speaking ability. The researcher used Pearson Product Moment Correlation in analyzing the data by using SPSS program 26 version.
Based on the results of the correlation analysis between the students’ grammar competency and the students speaking ability, the r value was obtained at 0.407 (r > 0.361) with p = 0.023 (p <0.05) indicating that there was a significant positive correlation between students’ grammar competency and students’ speaking ability. This supported the alternative hypothesis to be accepted and the null hypothesis to be rejected. It could be concluded that there was a correlation between grammar competency and speaking ability at the eighth grade students of SMPN 1 Palu in the academic year of 2020/2021.
Pre-breeding study for the enhancement of bioactive fruit attributes in strawberry (Fragaria x ananassa Duch.)
Authors: Żebrowska Jadwiga , Dyduch-Siemińska Magdalena , Gawroński Jacek , Jackowska Izabella , Pabich Marzena Justyna 
Published: December 2021

The strawberry fruit market increasingly demands new cultivars producing berries with enhanced bioactive attributes. In this research the suitability of twelve strawberry cultivars for effective breeding aimed at the enhancement of bioactive fruit attributes was studied. The group of genotypes with different pedigree was examined in respect of variation, breeding parameters, correlation between the content of bioactive compounds and the antioxidant capacity of fruit. Pre-breeding research showed the highly significant differences between genotypes regarding all traits analysed. Relationship between the bioactive phytochemicals content and antioxidant capacity of fruit were mostly positive and significant. Only correlation between vitamin C and flavonoids was negative (−0.482). Path analysis exhibited the highest positive direct effect of total phenolic content on antioxidant capacity (0.609). Heritability of traits was very high, reaching values above 0.90. The highest genetic advance was observed for flavonoids. Results suggested that the genotype plays the main role in shaping of fruit antioxidant potential. This study indicated that the efficient strawberry breeding focused on obtaining the forms with enhanced bioactive berry properties could be highly possible.
The Social Roots of Fears at the Start of the SARS-CoV-2 Pandemic. An Online Study of the Ethnic Hungarian Population in Romania
Authors: Sántha Ágnes , Telegdy Balázs , Gergely Orsolya , Nistor Laura 
Published: December 2021

Abstract
The paper addresses the issue of contamination fear within the context of the SARS-CoV-2 pandemic. The everyday lives and feelings of the ethnic Hungarian population in Transylvania, Romania, were investigated with an online survey in the middle of the lockdown, in April 2020. In the search for the socioeconomic and demographic determinants of perceived infection risk, we rely on descriptive and two-variable analysis as well as explanatory regression models controlling for covariates. The results show that respondents perceive public places to hold the highest risk of contamination from the virus. In the article, we also draw the sociodemographic profile of the “fearful” and “brave” attitudes towards the threat represented by the virus. Perceived infection risk is higher for the elderly, the more educated, and the non-religious people. The paper reveals that respondents’ concerns, beyond that of infection, are predominantly economic in character.
Natural Scientific and Ecological Environmental Education in the Training of Kindergarten Teacher Students at the University of Sopron, Hungary
Authors: Kendöl Jutka Nmarné 
Published: December 2021

Abstract
The greatest challenge of the 21st century is to recreate the disturbed balance between people and their environment. The functioning of the changed global system warns us about the multiplying of today’s global and local problems, which are affecting the world’s population. International organizations deal with this issue. In their opinion, environmental education and environmentally conscious thinking can be a way out of the crisis. The efficiency of environmental education is influenced by the ratio of theory and practice as well as the appropriately applied teaching methods, which is confirmed by the experience of the Ecology and Environmental Protection in Kindergarten course of the Benedek Elek Faculty of Pedagogy at the University of Sopron, Hungary.
Influence of saturation levels on transformer equivalent circuit model
Authors: Wang Yingying , Zhong Xingyu , Chen Xu 
Published: December 2021

Abstract
This paper presents a modelling approach for a transformer with different saturation levels. First, the magnetic field distributions at different saturation levels in the transformer are analyzed by using numerical simulations. Then, the characteristics of the leakage magnetic flux are analyzed, and the magnetic circuits with varying leakage reluctance topologies are modeled. Finally, based on the mature duality relationship between electric and magnetic circuits, the equivalent electric circuit models are obtained. These kinds of models embody the effect of different saturation levels on the connection points of the leakage flux branches, and it can fully reflect the various working states of the transformer. The accuracy of the models is verified by comparing the circuit simulation results with those of FEM transient simulations.