bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catalog of X-ray-selected extended galaxy clusters from the ROSAT All-Sky Survey (RXGCC)
Authors: Xu Weiwei , Ramos-Ceja Miriam E. , Pacaud Florian , Reiprich Thomas H. , Erben Thomas 
Published: November 2021

Context.There is a known tension between cosmological parameter constraints obtained from the primary cosmic microwave background and those drawn from galaxy cluster samples. One possible explanation for this discrepancy may be that the incomplete character of detected clusters is higher than estimated and, as a result, certain types of groups or galaxy clusters have been overlooked in the past.Aims.We aim to search for galaxy groups and clusters with particularly extended surface brightness distributions by creating a new X-ray-selected catalog of extended galaxy clusters from the ROSAT All-Sky Survey (RASS), based on a dedicated source detection and characterization algorithm that is optimized for extended sources.Methods.Our state-of-the-art algorithm includes multi-resolution filtering, source detection, and characterization. On the basis of extensive simulations, we investigated the detection efficiency and sample purity. We used previous cluster catalogs in X-ray and other bands, as well as spectroscopic and photometric redshifts of galaxies to identify clusters.Results.We report a catalog of galaxy clusters at high galactic latitude based on the ROSAT All-sky Survey, known as the RASS-based extended X-ray Galaxy Cluster Catalog, which includes 944 groups and clusters. Of this number, 641 clusters have been previously identified based on intra-cluster medium (ICM) emission (Bronze), 154 known optical and infrared clusters are detected as X-ray clusters for the first time (Silver) and 149 are identified as clusters for the first time (Gold). Based on 200 simulations, the contamination ratio of the detections that were identified as clusters by ICM emission and the detections that were identified as optical and infrared clusters in previous work is 0.008 and 0.100, respectively. Compared with the Bronze sample, the Gold+Silver sample is less luminous, less massive, and exhibits a flatter surface brightness profile. Specifically, the median flux in [0.1−2.4] keV band for Gold+Silver and Bronze sample is 2.496 × 10−12erg s−1cm−2and 4.955 × 10−12erg s−1cm−2, respectively. The median value ofβ(the slope of cluster surface brightness profile) is 0.76 and 0.83 for the Gold+Silver and Bronze sample, respectively.
Körpererfahrung und Körperinteraktion in der
psychotherapeutischen Anamnese- und Befunderhebung
Authors: Hausteiner-Wiehle Constanze , Henningsen Peter 
Published: November 2021

ZusammenfassungSchwierigkeiten mit Körpererfahrung und Körperinteraktion
kennzeichnen viele psychische und psychosomatische Erkrankungen und sind sowohl
für das Störungsverständnis als auch für die
Therapie eines konkreten Patienten relevant. Für ihre Diagnostik gibt es
eine Reihe von körperbezogenen Konstrukten, standardisierten
Messinstrumenten und Experimenten, die sich auf Einzelaspekte konzentrieren bzw.
einer kategorisierenden Auswertungslogik folgen. In der alltäglichen
psychotherapeutischen Diagnostik fehlt es aber an Begriffen und Methoden, um
Körpererfahrung und Körperinteraktion individuell und situativ
zu verstehen und zu nutzen. Dieses Diskussionspapier beschreibt auf der
Grundlage klinischer Erfahrungen und einer breiten, themengeleiteten
Literaturrecherche ihre wichtigsten Dimensionen – subjektives
Körpererleben, dargebotene Körpersprache, gezeigte und
verborgene körperliche Befunde, körperbezogene Narrative und
Handlungen, körperliche Resonanz – und wie sie in der klinischen
Interaktion durch Beobachtung, Mentalisierung und Bezogenheit erfasst werden
können.
Sexueller Selbstwert von Trans*Personen:
Fragebogenentwicklung und klinische Testung
Authors: Böhler Christoph , Lucht Luise , Göbel Philipp , Ried Rebekka , Wülfing Clara , Seikowski Kurt 
Published: November 2021

Zusammenfassung
Ziel der Studie In der vorliegenden Studie sollte ein neues Messinstrument zur
Erfassung sexuellen Selbstwerts in deutscher Sprache konstruiert und
hinsichtlich seiner faktoriellen Struktur, Validität und
Reliabilität untersucht werden. Anschließend sollte der
sexuelle Selbstwert bei Trans*Personen untersucht werden.
Methodik In einem ersten Schritt erfolgte die Konstruktion und Validierung an
einer Bevölkerungsstichprobe (N=426; Studie 1, online), es
wurden konfirmatorische Faktorenanalyse sowie statische Itemanalyse
durchgeführt. In einem zweiten Schritt erfolgte die
Ambulanzbefragung von Trans*Personen (N=85; Studie 2) zum
sexuellen Selbstwert, Körpererleben sowie psychischen und
psychosomatischen Beschwerden, zudem erfolgte ein Vergleich zur
Bevölkerungsstichprobe.
Ergebnisse Es konnten ein akzeptabler Modellfit und eine gute interne
Konsistenz für die finale eindimensionale 8-Item-Lösung der
sexuellen Selbstwertskala (SSWS) erreicht werden. Sexueller Selbstwert war
in der Normalbevölkerung moderat positiv mit globalem Selbstwert
assoziiert. Trans*Personen hatten einen signifikant geringeren
sexuellen Selbstwert im Vergleich zur Normalbevölkerung. Bei
Trans*Personen zeigten sich die erwarteten Zusammenhänge mit
Körpererleben, es fand sich jedoch kein Zusammenhang mit psychischen
und psychosomatischen Beschwerden.
Schlussfolgerung Die SSWS ist ein erstes deutschsprachiges und
geschlechtsneutrales Instrument zur Erfassung sexuellen Selbstwerts und
verfügt über gute psychometrische Eigenschaften. Sie
erscheint vielversprechend für die Verlaufs- und Erfolgskontrolle
der Transitionsbehandlung von Trans*Personen sowie für den
Einsatz in der Paar- und Sexualtherapie.
IL-27–producing B-1a cells suppress neuroinflammation and CNS autoimmune diseases
Authors: Choi Jin Kyeong , Yu Cheng-Rong , Bing So Jin , Jittayasothorn Yingyos , Mattapallil Mary J. , Kang Minkyung , Park Seung Bum , Lee Hyun-Su , Dong Lijin , Shi Guangpu , Caspi Rachel R. , Egwuagu Charles E. 
Published: November 2021

Significance

Importance of regulatory B cells (Breg cells) is underscored by scores of autoimmune, infectious, or neoplastic diseases that result from loss of Breg functions in vivo. We identified an innate B-1a Breg population in peritoneal cavity and human umbilical cord that suppresses encephalomyelitis or uveitis by propagating inhibitory signals that convert conventional lymphocytes to IL-35–secreting regulatory cells and inhibiting Lag3
+
PD-1
+
T cells that mediate CNS autoimmune diseases. Furthermore, IRF8 signaling is required for i27-Breg development and loss of IL-27Rα or IL-27 function in B cells abrogates capacity of i27-Bregs to suppress diseases or induce B-1a differentiation into i27-Breg. i27-Breg requires activation by innate stimuli and is not antigen-specific, suggesting that i27-Breg would be effective immunotherapy for diverse autoimmune diseases.
Agonistic analog of growth hormone–releasing hormone promotes neurofunctional recovery and neural regeneration in ischemic stroke
Authors: Liu Yueyang , Yang Jingyu , Che Xiaohang , Huang Jianhua , Zhang Xianyang , Fu Xiaoxiao , Cai Jialing , Yao Yang , Zhang Haotian , Cai Ruiping , Su Xiaomin , Xu Qian , Ren Fu , Cai Renzhi , Schally Andrew V. , Zhou Ming-Sheng 
Published: November 2021

Significance
Stroke is a leading cause of mortality and permanent disability in adults worldwide. Although most pharmacological neuroprotectants have beneficial effects in experimental studies, they fail in clinical trials. Here, we report that MR-409, a synthetic analog of growth hormone–releasing hormone, can reduce mortality and improve neurological functional recovery in mice operated on for tMCAO. Mechanistically, MR-409 stimulates endogenous neurogenesis and improves tMCAO-induced loss of neuroplasticity by activation of AKT/CREB and BDNF/TrkB pathways. Our preclinical studies support the notion that MR-409 has remarkable neuroprotective effects through enhancing endogenous neurogenesis and may represent a potential new therapy for cerebral ischemic stroke.
Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins
Authors: Bloch Joël S. , Mukherjee Somnath , Kowal Julia , Filippova Ekaterina V. , Niederer Martina , Pardon Els , Steyaert Jan , Kossiakoff Anthony A. , Locher Kaspar P. 
Published: November 2021

SignificanceStructural studies of membrane proteins by cryogenic electron microscopy (cryo-EM) often require antibody fragments (Fabs) to facilitate particle alignments and achieve high resolution. While conformational nanobodies have been developed to lock specific states of many membrane proteins, they only add 15 kDa of mass to the complex. We developed a synthetic Fab (NabFab) that rigidly binds the conserved scaffold of nanobodies, providing a universally applicable fiducial for cryo-EM studies of protein–nanobody complexes. We demonstrate the concept by determining two high-resolution structures of membrane proteins bound to specific nanobodies and NabFab. As the structural epitope for NabFab can be incorporated into the scaffold of virtually any nanobody, this raises the prospect of facile structure determination of many nanobody–protein complexes.
Theoretical analysis of RNA polymerase fidelity: a steady-state copolymerization approach
Authors: Fu Wenbo , Li Qiushi , Song Yongshun , Shu Yaogen , Ouyang Zhongcan , Li Ming 
Published: November 2021

Abstract
The fidelity of DNA transcription catalyzed by RNA polymerase (RNAP) has long been an important issue in biology. Experiments have revealed that RNAP can incorporate matched nucleotides selectively and proofread the incorporated mismatched nucleotides. However, systematic theoretical researches on RNAP fidelity are still lacking. In the last decade, several theories on RNA transcription have been proposed, but they only handled highly simplified models without considering the high-order neighbor effects and the oligonucleotides cleavage both of which are critical for the overall fidelity. In this paper, we regard RNA transcription as a binary copolymerization process and calculate the transcription fidelity by the steady-state copolymerization theory recently proposed by us for DNA replication. With this theory, the more realistic models considering higher-order neighbor effects, oligonucleotides cleavage, multi-step incorporation and multi-step cleavage can be rigorously handled.
The angular momentum and parity projected multidimensionally constrained relativistic Hartree–Bogoliubov model
Authors: Wang Kun , Lu Bing-Nan 
Published: November 2021

Abstract
Nuclear deformations are fundamentally important in nuclear physics. We recently developed a multidimensionally constrained relativistic Hartree–Bogoliubov (MDCRHB) model, in which all multipole deformations respecting the V
4 symmetry can be considered self-consistently. In this work we extend this model by incorporating the angular momentum projection and parity projection to restore the rotational and parity symmetries broken in the mean-field level. This projected MDCRHB (p-MDCRHB) model enables us to connect certain nuclear spectra to exotic intrinsic shapes such as triangles or tetrahedrons. We present the details of the method and an exemplary calculation for 12C. We develop a triangular moment constraint to generate the triangular configurations consisting of three α clusters arranged as an equilateral triangle. The resulting 12C spectra are consistent with that from a triangular rigid rotor for large separations between the α clusters. We also calculate the B(E2) and B(E3) values for low-lying states and find good agreement with the experiments.
Topological properties of non-Hermitian Creutz ladders
Authors: Liang Hui-Qiang , Li Linhu 
Published: November 2021

Abstract
We study topological properties of the one-dimensional Creutz ladder model with different non-Hermitian asymmetric hoppings and on-site imaginary potentials, and obtain phase diagrams regarding the presence and absence of an energy gap and in-gap edge modes. The non-Hermitian skin effect (NHSE), which is known to break the bulk–boundary correspondence (BBC), emerges in the system only when the non-Hermiticity induces certain unbalanced non-reciprocity along the ladder. The topological properties of the model are found to be more sophisticated than that of its Hermitian counterpart, whether with or without the NHSE. In one scenario without the NHSE, the topological winding is found to exist in a two-dimensional plane embedded in a four-dimensional space of the complex Hamiltonian vector. The NHSE itself also possesses some unusual behaviors in this system, including a high spectral winding without the presence of long-range hoppings, and a competition between two types of the NHSE, with the same and opposite inverse localization lengths for the two bands, respectively. Furthermore, it is found that the NHSE in this model does not always break the conventional BBC, which is also associated with whether the band gap closes at exceptional points under the periodic boundary condition.
SNPs detection in 5’-UTR region of the MC4R gene in Garut sheep
Authors: L Sari A P Z N , Athifa I R , Panjono  , Hidayat R , Barli A , Maharani D 
Published: November 2021

Abstract
The melanocortin-4 receptor (MC4R) gene has been linked to controlling feeding behavior and body weight. The objective of this study was to detect the polymorphism within the 5’-UTR region of the MC4R gene in Garut sheep. A total of 36 blood samples were isolated and amplified using primers (forward: 5’-TTCGTTTGGGGCAAGTCAAG-3’ and reverse: 5’-GGAAACGCTCACCAACATGT-3’). Two SNPs, g.396C/T and g.399C/G, were discovered in the 5‘UTR region based on sequence alignment (position number based on Genbank acc no. NC_040274). For both SNPs, only two genotypes were found in the samples. Both SNPs had identical allele and genotype frequencies. The C allele (86%, n=26) was higher than the T (g.396C/T) and G allele (g.399C/G) (14%, n=10). The homozygous CC genotype has a higher frequency (72%) in both SNP g.396C/T and g.399C/G, followed by CT and CG genotype (28%), respectively. The Hardy-Weinberg equilibrium analysis resulted in the sample population did not deviate (χ2<5.59). Further analysis could be suggested to provide an overview of this polymorphism effect in Garut sheep’s growth traits.
Evaluation of multi decked transported sheep in a hot and humid tropical environment
Authors: Lendrawati  , Priyanto R , Jayanegara A , Manalu W , Desrial  
Published: November 2021

AbstractUnavoidable transportation as a supporting factor in meat production is a common cause of stress that may affect economic loss and welfare concerns. This study was evaluated sheep’s economic losses and physiological responses with two and three-level deck numbers. This study was used 127 heads of local Indonesian sheep, 8-10 months in age with 18-24 kg live body weight. A total of 72 heads of sheep were used for three deck levels (study 1) and 52 heads of two deck levels (study 2). All the sheep were loaded on the pick up at a 0.14 m2/head of density and transported for 22 hours without fed and water access during the journey. During the study, ambient temperature and relative humidity fluctuated between 29 and 34oC and 74 and 93%, indicating that the season was thermally stressful and unfavorable for sheep transport. The results showed that transported sheep using an open pick up for 20 hours in Indonesian conditions significantly affected physiological and blood parameters as indicator stress and inventory loss caused economic losses. It can be concluded that transported sheep into two or three levels of the deck in tropical climate had a high risk for sheep in terms of economic and animal welfare concerns.
The effect of slaughter age and sex class to carcass characteristic of Red Brahman Crossbred Cattle
Authors: Maulid S S C , Susilo A , Purwanto D , Kuswati  
Published: November 2021

Abstract
This research was conducted to examine the effect of slaughter age and sex class to carcass characteristic from Red Brahman Crossbred Cattle. The research materials were 126 heads (grouped by slaughter age (<1,5 years, 2-2,5 years, and 3 years) and sex class (bull and steer)) with taken from KASA Company, rested for 12-24 hours, and slaughtered in AM FARM abattoir with halal MUI slaughter methods. The research method was used field experiment. The data of research were analysis by using Complete Randomized Factorial Design (2X3) and Duncan Multiple Range Test if there were differences. Parameters of carcass characteristic were slaughter weight, hot carcass weight, dressing percentage, carcass components percentage (meat, bone, fat), MBR, MFR, rib eyes area, and 12th fat thickness of ribs. The results of this research showed that slaughter age and sex class has significantly (P<0,05) affect to slaughter weight and hot carcass weight. Interactions of slaughter age and sex class has significantly (P<0,05) affect dressing percentage, bone and meat percentage, MBR and MFR, and has not significant (P>0,05) rib eyes area and fat thickness. From these results, it can be concluded that slaughter age and sex class affect carcass characteristics of Red Brahman Crossbred Cattle.
The influence of the mixture of some plant powder with Anacardium occidentale shell liquid smoke on total bacteria and Escherichia coli in the ileum of broiler
Authors: Pasaribu T , Kostaman T , Saenab A 
Published: November 2021

Abstract
Antibiotics/feed additives are commonly used in poultry rations to prevent disease, increase feed efficiency, and improve performance. Plants are the alternatives to replace antibiotics that are safe and without side effects for chicken meat consumers. The aim of this study was to evaluate the effect of administration of a mixture of plant powder and Anacardium occidentale shell liquid smoke on the total bacteria and Escherichia coli in the broiler ileum. The plant mixture was: Phyllanthus niruri L. (PNP) powder: Anacardium occidentale shell liquid smoke (AOLS): Syzygium aromaticum leaf powder (SAP). The study used a Completely Randomized Design. In total, 80 one-day-old broiler chicks were allotted randomly into eight treatments with two replicates per treatment and 5 birds per replicate. The study with the following treatments: Control, Zn-Bacitracin 0.05%, T1 (1.25%: 0.125%: 0.313%), T2 (1.25%: 0.125%: 0.157%), T3 (0.625%: 0.125%: 0.157%). T4 (0.625%: 0.0625: 0.157%), T5 (0.313%: 0.0313: 0.625%), T6 (0.313%: 0.125%: 0.313%). To find out the total bacteria and Escherichia coli, the chicken is then slaughtered 2 hens per replicates to collect feces from the ileum. The results showed that the treatment of the mixture of PNP: AOLS: SAP was not significantly different (P>0.05) with Zn-bacitracin treatment on the total bacteria and Escherichia coli. However, the number of bacteria in T1 was lower than that of the Zn-bacitracin treatment, while the number of Escherichia coli in T1 was closer to the Zn-bacitracin treatment. It can be concluded that the PNP: AOLS: SAP (1.25%: 0.125%: 0.313%) mixture at T1 treatment has the potential as a natural antibiotic to replace Zn-bacitracin antibiotic in inhibiting total growth of bacteria and Escherichia coli in the ileum of broiler.
Potential and characteristics of dadiah processed into products-like nuggets with addition of cinnamon bark flour (Cinnamomum burmanni)
Authors: Sandra A , Purwati E , Hasibuan A 
Published: November 2021

Abstract
Dadiah is a natural fermentation of buffalo milk from West Sumatra, which has a distinctive smell and flavor. This causes the dadiah to be less liked, so it is necessary to diversify the processed of dadiah. This study aimed to determine the effect of adding cinnamon flour (Cinnamomum burmanni) in the processing of nugget-like products on antioxidants, cholesterol, the total colony of lactic acid bacteria and organoleptic values. This research used 2000 grams of dadiah and cinnamon bark flour (15 g). The variables observed were antioxidants, cholesterol, the total colony of lactic acid bacteria and organoleptic values. The method used in this study was an experimental method using a Completely Randomized Design (CRD) with 4 treatments and 5 replications. The treatments in this study were the addition of cinnamon flour namely A (0%), B (0.5%), C (1%), D (1.5%). The results of this study indicated that the addition of cinnamon flour to nugget-like products had a significant effect (P<0.05) increasing antioxidant levels and decreasing cholesterol levels, not significantly different (P> 0.05) on the total colony test of lactic acid bacteria and the organoleptic test of taste, texture and flavor. The addition of cinnamon flour to nugget-like products in treatment D (1.5%) gave the best results with antioxidant levels of 73.24%, cholesterol levels of 20.32 mg/dl, the total colony of lactic acid bacteria 1.48x107 CFU / ml and taste organoleptic value 3.44, texture 3.68 and flavor 3.80.
Occurrence of polycyclic aromatic hydrocarbons (PAHs) carcinogen in Indonesian commercial goat satay
Authors: Saputro E , Radiati L E , Warsito W , Rosyidi D 
Published: November 2021

Abstract
This study aimed to investigate the carcinogen content of polycyclic aromatic hydrocarbons (PAHs) in commercial charcoal grilled goat satay. Twenty-one portions of commercial raw goat satay and charcoal grilled goat satay samples were obtained from 4 restaurants which are the largest, well-known, and 15-55 years old goat satay restaurant in Batu Municipality, East Java. Sampling of 2 goat satay types (goat satay without sliced fat and goat satay with sliced fat) was carried out 3 replications in 3 consecutive weekends where many tourists visited. The results showed that the temperature of wood charcoal for grilling commercial raw goat satay in various satay restaurants ranged 486.833-548.300 oC with a grilling duration of 2-5.5 minutes and grilling distance of 0.5-2 cm. The weight of raw goat satay for a serving (10 skewers) ranged 144.000-194.000 g and after grilling the weight ranged 97.333-148.000 g. Total natural antioxidant activity (Dipheny-picrylhydrazyl, DPPH), fat content and moisture content of raw goat satay with sliced fat and without sliced fat reached up to 36.661 and 34.124%; 13.440-26.100% and 1.5-6.305%; 57.940-66.385% and 71.530-76.810%, respectively. Benzo(a)pyrene (BaP), the only type of PAHs that is carcinogenic, for charcoal grilled goat satay with sliced fat and without sliced fat in various satay restaurants, ranged from not detected to 6.330 mg/kg and not detected to 0.773 mg/kg, respectively. The levels of BaP in charcoal grilled goat satay in several satay restaurants exceeded the safety limit by National Agency of Drug and Food Control (NA-DFC) of Republic Indonesia. Benzo(a)antharacene (BaA) and pyrene (Pyr) were detected in all grilled goat satay samples in various satay restaurants. Whereas, phenanthrene (Phe), acenaphthene (Acp) and naphthalene (Nap) were not detected in all grilled goat satay samples in various satay restaurants. The conclusion of our study was that the commercial charcoal grilled goat satay that are sold in Batu municipality contains PAH, especially the carcinogenic B(a)P. Therefore practical mitigation efforts are needed for producers to reduce and prevent the formation of carcinogenic B(a)P in commercial charcoal grilled goat satay.