bluuebunny/crossref_metadata_2025_split huggingface dataset:
PAD4 controls chemoattractant production and neutrophil trafficking in malaria
Authors: Cela Drinalda , Knackstedt Sebastian Lorenz , Groves Sarah , Rice Christopher M , Kwon Jamie Tae Wook , Mordmüller Benjamin , Amulic Borko 
Published: November 2021

AbstractPeptidylarginine deiminase 4 (PAD4) is a key regulator of inflammation but its function in infections remains incompletely understood. We investigate PAD4 in the context of malaria and demonstrate a role in regulation of immune cell trafficking and chemokine production. PAD4 regulates liver immunopathology by promoting neutrophil trafficking in a Plasmodium chabaudi mouse malaria model. In human macrophages, PAD4 regulates expression of CXCL chemokines in response to stimulation with TLR ligands and P. falciparum. Using patient samples, we show that CXCL1 may be a biomarker for severe malaria. PAD4 inhibition promotes disease tolerance and may represent a therapeutic avenue in malaria.
Multicentric Study on High‐Frequency Ultrasound Characterization of Calcium Deposits in Dermal and Subcutaneous Calciphylaxis and Calcinosis
Authors: Gamissans Marta , Giavedoni Priscila , Roe Esther , Sánchez Julia , Quintana‐Codina Monica , Garbayo‐Salmons Patricia , Vidal David , Riera‐Martí Núria , López‐Llunell Cristina , Romaní Jorge , Wortsman Ximena 
Published: November 2021

ObjectivesCalcium depositions are frequent in multiple inflammatory dermatosis, they can be explored by ultrasound (US) but the patterns of these depositions have not yet been described. The aim of this study is to describe different patterns of calcium deposition in inflammatory dermatoses.MethodsThe clinical and US data of 58 patients from 7 different centers with inflammatory dermatosis showing ultrasonography‐detected calcium depositions was retrospectively reviewed.ResultsDystrophic calcinosis represented 86.2%, calciphylaxis 8.6%, and metastatic calcinosis 5.2%. Three different sonographic patterns of calcium deposition were found: 1) thin hyperechoic bands, parallel to the surface of the epidermis, generating a strong and wide posterior acoustic shadow; 2) hyperechoic spots or lumps with a narrow acoustic shadow; and 3) a linear hyperechoic band parallel to the walls of a blood vessel with also a narrow acoustic shadow. The predominant pattern in metastatic calcifications was type 1, in dystrophic calcifications type 2, and in calciphylaxis type 3. In dystrophic calcinosis, cutis deposits were longer and wider than in calciphylaxis (P < .05).ConclusionNew data on inflammatory dermatoses with calcium deposition may be useful for the diagnosis and monitoring of calcium deposits and could avoid the performance of more invasive tests, such as a skin biopsy.
Composite Hydrogels of Alkyl Functionalized Gellan Gum Derivative and Hydroxyapatite/Tricalcium Phosphate Nanoparticles as Injectable Scaffolds for bone Regeneration
Authors: Pitarresi Giovanna , Palumbo Fabio Salvatore , Fiorica Calogero , Bongiovì Flavia , Martorana Annalisa , Federico Salvatore , Chinnici Cinzia Maria , Giammona Gaetano 
Published: November 2021

AbstractAn alkyl functionalized gellan gum derivative is here used to produce hydrogels containing hydroxyapatite and tricalcium phosphate nanoparticles as injectable nanostructured scaffolds for bone regeneration. The amphiphilic nature of the polysaccharide derivative along with its thermotropic behavior and ionotropic crosslinking features make possible to produce injectable bone mimetic scaffolds that can be used to release viable cells and osteoinductive biomolecules. The influence of different nanoparticles concentration on the rheological and physicochemical properties of the injectable systems is studied. It is found that the presence of inorganic nanoparticles reinforces the 3D hydrated polymeric networks without influencing their injectability but improving the physicochemical properties of ionotropic crosslinked hydrogels produced with two different curing media. Preliminary cytocompatibility tests performed with murine preosteoblast cells revealed that gellan gum based hydrogels can safely encapsulate viable cells. Loading and release experiments for dexamethasone and stromal cell‐derived factor‐1 demonstrate the drug delivery features of the obtained injectable systems.
Black Freedom, Black Markets: Notes on New Orleans Black Masking Indian Tradition
Authors: Perry Marc D. 
Published: November 2021

AbstractThis article explores some of the complexities between Black beauty, alterities of Black possibility, and oppositional refusal on one hand, and Black vulnerability—if not expendability—on the other as lived among members of New Orleans Black Masking Indian community vis‐à‐vis the city’s tourist‐driven cultural economy. At center sits a dichotomy of Blackness that figures some African American New Orleanians as commercially assimilable and therefore valued Black subjects, and those otherwise deemed un‐assimilable and hence ultimately dispensable. Amid such bifurcated economies of desire/disposability generative of a kind of “contractual Blackness,” some Black Masking members craft entrepreneurial strategies through which local African American cultural traditions serve as currencies that afford entry to a raced marketplace otherwise largely inaccessible. While such creative agencies suggest a critical foregrounding of Black subjects rather than simple objects of market consumption, they also appear to underscore some of the ambiguities, if not enduring vulnerabilities of Black refusal and its liberatory promise amid the current moment.
Relationship between public sector reforms and culture: The implementation of NPM‐related performance management reforms in a collectivist and risk averse culture
Authors: Ugyel Lhawang 
Published: November 2021

AbstractAs performance management reforms gain traction worldwide, their implementation, however, has demonstrated mixed results. This trend is visible in the manner countries have adopted and implemented New Public Management (NPM)‐related public sector reforms that are based on the neo‐classical and business models of organisation and management. Experiences in various countries demonstrate that the inherent individualistic aspects of NPM‐related performance management do not suit the context of countries with a collective culture. The introduction of a series of NPM‐related performance management reforms introduced to Bhutan’s civil service over the last 15 years explores the relationship between public sector reforms and culture. This article highlights the challenges faced in the implementation of performance management reforms in Bhutan’s collectivist and risk averse culture. Bhutan’s experience in the implementation of NPM‐related reforms provide an insightful lesson for other countries with similar culture and context.
US emergency department visits for acute harms from over‐the‐counter cough and cold medications, 2017–2019
Authors: Mital Rohan , Lovegrove Maribeth C. , Moro Ruth N. , Geller Andrew I. , Weidle Nina J. , Lind Jennifer N. , Budnitz Daniel S. 
Published: November 2021

AbstractBackground and PurposeCharacterization of emergency department (ED) visits for acute harms related to use of over‐the‐counter cough and cold medications (CCMs) by patient demographics, intent of CCM use, concurrent substance use, and clinical manifestations can help guide prevention of medication harms.MethodsPublic health surveillance data from the National Electronic Injury Surveillance System‐Cooperative Adverse Drug Event Surveillance project were used to estimate numbers and population rates of ED visits from 2017 to 2019.ResultsBased on 1396 surveillance cases, there were an estimated 26 735 (95% CI, 21 679‐31 791) US ED visits for CCM‐related harms annually, accounting for 1.3% (95% CI, 1.2–1.5%) of all ED visits for medication adverse events. Three fifths (61.4%, 95% CI, 55.6–67.2%) of these visits were attributed to non‐therapeutic CCM use (nonmedical use, self‐harm, unsupervised pediatric exposures). Most visits by children aged <4 years (74.0%, 95% CI, 59.7–88.3%) were for unsupervised CCM exposures. Proportion hospitalized was higher for visits for self‐harm (76.5%, 95% CI, 68.9–84.2%) than for visits for nonmedical use (30.3%, 95% CI, 21.1–39.6%) and therapeutic use (8.8%, 95% CI, 5.9–11.8%). Overall, estimated population rates of ED visits for CCM‐related harms were higher for patients aged 12–34 years (16.5 per 100 000, 95% CI, 13.0–20.0) compared with patients aged <12 years (5.1 per 100 000, 95% CI, 3.6–6.5) and ≥ 35 years (4.3 per 100 000, 95% CI, 3.4–5.1). Concurrent use of other medications, illicit drugs, or alcohol was frequent in ED visits for nonmedical use (61.3%) and self‐harm (75.9%).ConclusionsContinued national surveillance of CCM‐related harms can assess progress toward safer use.
Cooperative deterministic learning and formation control for underactuated USVs with prescribed performance
Authors: He Shude , Dong Chao , Dai Shi‐Lu , Zou Tao 
Published: November 2021

AbstractIn this article, we aim to address the problem of cooperative learning from adaptive neural formation control for a group of underactuated unmanned surface vehicles (USVs) with modeling uncertainties, where the formation errors are subject to prescribed performance constraints. A coordinate transformation is introduced to overcome the difficulties caused by off‐diagonal system matrix. Under limited communication range, the connectivity preservation as well as collision avoidance among the initial connected vehicles are achieved by guaranteeing the intervehicle distances converge to small neighborhoods of the desired distance. Meanwhile, the convergence of bearing angles to small neighborhoods of desired bearing angles avoids the possible controller singularity problem arising from underactuation and achieves the predefined formation shape. The prescribed performance constraints are imposed on the formation errors to improve the transient and steady‐state performances. Using the deterministic learning theory, the modeling uncertainties are locally accurately identified/learned by the localized radial basis function (RBF) neural networks (NNs) along the union of all vehicles' state orbits in a cooperative way. The learned knowledge is stored in constant RBF networks and is reutilized to develop experience‐based formation control protocol to improve the control performance including reduction of the computational burden. Simulations are carried out to verify the effectiveness of the proposed formation controllers.
Analysis of Decisive Structural Parameters and Acidic Property of Zeolites for Gas‐Phase Alkylation of Benzene with Ethylene
Authors: Zhai Yunping , Wang Youju , Chen Junwen , Liang Shihang , Wang Yongrui , Luo Yibin , Shu Xingtian 
Published: November 2021

AbstractThe effects of the zeolite structure and acidic property on the activity and selectivity in gas‐phase alkylation of benzene with ethylene were investigated using TUN, IMF, *SFV and MFI with different structures and Si/Al2 ratios. The channels of TUN and IMF provide both higher selectivity to ethylation (ethylbenzene and di‐ethylbenzene) and lower xylene selectivity compared to MFI with slightly smaller pore diameter in which the pore diffusion limitations are suffered. The activity is mainly controlled by zeolite channel architecture. The higher activity and selectivity are obtained using modified TUN and modified IMF with suitable density of Brønsted acidity in a well‐defined channel structure sterically constrained for heavy by‐products. It is shown that the activity and selectivity increase with increasing pore diameter of three‐dimensional 10 ring channel structure, while the rule is not valid for *SFV.
A large scale parallel fluid‐structure interaction computing platform for simulating structural responses to a detonation shock
Authors: Zhang Sen , Guo Xiao‐Wei , Li Chao , Liu Yi , Fan Sijiang , Zhao Ran , Yang Canqun 
Published: November 2021

AbstractDue to the intrinsic nature of multi‐physics, it is prohibitively complex to design and implement a simulation software platform for study of structural responses to a detonation shock. In this article, a partitioned fluid‐structure interaction computing platform is designed for parallel simulating structural responses to a detonation shock. The detonation and wave propagation are modeled in an open‐source multi‐component solver based on OpenFOAM and blastFoam, and the structural responses are simulated through the finite element library deal.II. To capture the interaction dynamics between the fluid and the structure, both solvers are adapted to preCICE. For improving the parallel performance of the computing platform, the inter‐solver data is exchanged by peer‐to‐peer communications and the intermediate server in conventional multi‐physics software is eliminated. Furthermore, the coupled solver with detonation support has been deployed on a computing cluster after considering the distributed data storage and load‐balancing between solvers. The 3D numerical result of structural responses to a detonation shock is presented and analyzed. On 256 processor cores, the speedup ratio of the simulations for a detonation shock reach 178.0 with 5.1 million of mesh cells and the parallel efficiency achieve 69.5%. The results demonstrate good potential of massively parallel simulations. Overall, a general‐purpose fluid‐structure interaction software platform with detonation support is proposed by integrating open source codes. And this work has important practical significance for engineering application in fields of construction blasting, mining, and so forth.
Acquisition strategy factors related to faster defense acquisitions
Authors: Etemadi Amir , Kamp John 
Published: November 2021

AbstractThe Department of Defense is experimenting with rapid acquisition strategies intended to deliver new capabilities in 2–5 years. There are few historical examples of programs achieving such cycle times – the duration from program start to initial operational capability within such short durations. This paper summarizes recent research between strategy decisions during program development and eventual program durations. Regression models are developed providing initial estimates of program schedule durations and growth from a few planning decisions. Program offices may use similar models and relationships as part of setting realistic program schedule expectations.
Epistemologische Neupositionierungen. Alexander Mitscherlich zwischen „naturwissenschaftlicher Methodik“, Psychoanalyse und Psychosomatischer Medizin
Authors: Dörre Steffen 
Published: November 2021

ZusammenfassungAnhand von Alexander Mitscherlichs Plädoyers für eine Psychosomatische Medizin werden dessen epistemologische Neupositionierungen in den 1940er, 1950er und 1960er Jahren untersucht. Sie eröffnen den Blick auf die Auseinandersetzung von Psychiatern, Internisten und Psychotherapeuten um valides und handlungsrelevantes Wissen in der Nachkriegszeit. Zentral war für Mitscherlich ein Krankheitsverständnis, das der Subjektivität der Patienten einen festen Platz zuwies. Damit verbunden war eine kontinuierliche Kritik an statistischen Verfahren zur Validierung von Einzelbefunden und Hypothesen. Gezeigt wird, wie anpassungsfähig Mitscherlich mit seiner Kritik an einer naturwissenschaftlich orientierten Methodik in der Medizin war, wenngleich er die ursprüngliche Stoßrichtung trotz aller Wandlungen aufrechterhielt.
Methodological development for the optimisation of electricity cost in cement factories: the use of artificial intelligence in process variables
Authors: Parejo Guzmán Manuel , Navarrete Rubia Benito , Mora Peris Pedro , Alfalla-Luque Rafaela 
Published: November 2021

AbstractCement factories require large amounts of energy. 70% of the variable cost goes to energy—33% to kiln thermal energy and 37% to electrical energy. This paper represents the second stage of a broader research study which aims at optimising electricity cost in a cement factory by means of using artificial intelligence. After an analysis of the different tools that could be highly useful for the optimisation of electricity cost, for which a systematic review of the literature and surveys and an expert panel of 42 professionals in the cement sector were carried out, a methodology was developed in order to reduce electricity cost by optimising not only different variables of the production process, but also regulated electricity costs and electricity market costs. Artificial neural networks and genetic algorithms will be the tools to be used in this methodology, which can be applied to any cement plant in the world, and, by extension, to any electro-intensive consumer. The innovation of this research work is based on the use of a methodology that not only combines two different variables at the same time—process variables and regulated prices—but also makes use of artificial intelligence tools techniques.
Patient-reported outcomes during repetitive oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy for isolated unresectable colorectal peritoneal metastases in a multicenter, single-arm, phase 2 trial (CRC-PIPAC)
Authors: Lurvink Robin J. , Rovers Koen P. , Wassenaar Emma C. E. , Bakkers Checca , Burger Jacobus W. A. , Creemers Geert-Jan M. , Los Maartje , Mols Floortje , Wiezer Marinus J. , Nienhuijs Simon W. , Boerma Djamila , de Hingh Ignace H. J. T. 
Published: November 2021

Abstract
Background
CRC-PIPAC prospectively assessed repetitive oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy (PIPAC-OX) as a palliative monotherapy (i.e., without concomitant systemic therapy in between subsequent procedures) for unresectable colorectal peritoneal metastases (CPM). The present study explored patient-reported outcomes (PROs) during trial treatment.

Methods
In this single-arm phase 2 trial in two tertiary centers, patients with isolated unresectable CPM received 6-weekly PIPAC-OX (92 mg/m2). PROs (calculated from EQ-5D-5L, and EORTC QLQ-C30 and QLQ-CR29) were compared between baseline and 1 and 4 weeks after the first three procedures using linear mixed modeling with determination of clinical relevance (Cohen’s D ≥ 0.50) of statistically significant differences.

Results
Twenty patients underwent 59 procedures (median 3 [range 1–6]). Several PROs solely worsened 1 week after the first procedure (index value − 0.10, p < 0.001; physical functioning − 20, p < 0.001; role functioning − 27, p < 0.001; social functioning − 18, p < 0.001; C30 summary score − 16, p < 0.001; appetite loss + 15, p = 0.007; diarrhea + 15, p = 0.002; urinary frequency + 13, p = 0.004; flatulence + 13, p = 0.001). These PROs returned to baseline at subsequent time points. Other PROs worsened 1 week after the first procedure (fatigue + 23, p < 0.001; pain + 29, p < 0.001; abdominal pain + 32, p < 0.001), second procedure (fatigue + 20, p < 0.001; pain + 21, p < 0.001; abdominal pain + 20, p = 0.002), and third procedure (pain + 22, p < 0.001; abdominal pain + 22, p = 0.002). Except for appetite loss, all changes were clinically relevant. All analyzed PROs returned to baseline 4 weeks after the third procedure.

Conclusions
Patients receiving repetitive PIPAC-OX monotherapy for unresectable CPM had clinically relevant but reversible worsening of several PROs, mainly 1 week after the first procedure.

Trial registration
Clinicaltrials.gov: NCT03246321; Netherlands trial register: NL6426.
Burden of depression and anxiety disorders per disease codes in patients with lymphoma in Germany
Authors: Tilch Marie-Kristin , Galle Peter R. , Schattenberg Jörn M. , Kostev Karel , Labenz Christian 
Published: November 2021

Abstract
Purpose
The aim of this study was to explore the incidence of depression and anxiety disorder diagnoses in a large German cohort of patients with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) diagnoses in comparison to patients without cancer over a 10-year time frame.

Methods
Patients with HL (n=687) and NHL (n=4130) were matched to cohorts without a cancer diagnosis (n=687 and 4130) by age, sex, and yearly consultation frequency. The primary outcome of the study was the incidence of depression and anxiety disorders. The relationship between lymphoma, separated into HL and NHL, and both depression and anxiety disorders was investigated using Cox regression models.

Results
We compared 687 patients with HL with 687 matched non-cancer individuals and 4130 patients with NHL with 4130 matched non-cancer individuals. Within 10 years of the index date, 24.0% of patients with HL and 22.3% of patients with NHL were diagnosed with depression. Anxiety disorders were diagnosed in 6.7% and 5.3% of patients with HL and NHL, respectively. On regression analyses, HL (HR 2.30, 95% CI 1.65–3.21, p<0.001) and NHL (HR 2.09, 95% CI 1.81–2.41, p<0.001) were positively associated with incident depression. The HR for anxiety disorders was 1.64 (95% CI 1.24–2.16, p<0.001) in patients with NHL, while HL was not associated with incident anxiety disorders (HR 1.21, 95% CI 0.71–2.07, p<0.478).

Conclusion
Lymphoma constitutes a risk factor for emerging depression and anxiety disorders. Following the diagnosis of lymphoma, screening and strategies to prevent the occurrence of these diseases seem warranted.
A Plea for the Comprehensiveness of the Category of Moral “Luck”
Authors: Zaborowski Robert 
Published: November 2021

AbstractThe aim of this paper is to improve our understanding of the category of moral “luck”. In current debate most often only specific cases of moral “luck” are taken into account. Such restrictions, however, involving a fragmentary picture of moral "luck", are introduced without any rationale for them. In this paper I look for a formal comprehensiveness of the category of moral “luck”. I consider three factors each of which is developed in two scenarios. These are (i) whether the agent’s action is nasty or nice, (ii) whether the agent’s intention is confirmed or contradicted by her action, and (iii) whether the agent’s action is preceded by her intention or the lack thereof. I explore eight scenarios which are a mark of the intricacy of the category of moral “luck” otherwise ignored in the literature. After an assessment of their structure I arrive at new distinctions. The upshot is a rather complex set of correlations between several cases of moral “luck” with a variety of kinds and shades.
A computational method for detecting aspect ratio and problematic features in additive manufacturing
Authors: Ge Ruihuan , Flynn Joseph 
Published: November 2021

AbstractIn metal additive manufacturing, geometries with high aspect ratio (AR) features are often associated with defects caused by thermal stresses and other related build failures. Ideally, excessively high AR features would be detected and removed in the design phase to avoid unwanted failure during manufacture. However, AR is scale and orientation independent and identifying features across all scales and orientations is exceptionally challenging. Furthermore, not all high AR features are as easy to recognise as thin walls and fine needles. There is therefore a pressing need for further development in the field of problematic features detection for additive manufacturing processes. In this work, a dimensionless ratio (D1/D2) based on two distance metrics that are extracted from triangulated mesh geometries is proposed. Based on this method, geometries with different features (e.g. thin wall, helices and polyhedra) were generated and evaluated to produce metrics that are similar to AR. The prediction results are compared with known theoretical AR values of typical geometries.By combining this metric with mesh segmentation, this method was further extended to analyse the geometry with complex features. The proposed method provides a powerful, general and promising way to automatically detect high AR features and tackle the relevant defect issues prior to manufacture.