bluuebunny/crossref_metadata_2025_split huggingface dataset:
AACC Practical Recommendations for Implementing and Interpreting SARS-CoV-2 Emergency Use Authorization and Laboratory-Developed Test Serologic Testing in Clinical Laboratories
Authors: Zhang Y Victoria , Wiencek Joesph , Meng Qing H , Theel Elitza S , Babic Nikolina , Sepiashvili Lusia , Pecora Nicole D , Slev Patricia , Cameron Andrew , Konforte Danijela 
Published: March 2021

Abstract

Background
The clinical laboratory continues to play a critical role in managing the coronavirus pandemic. Numerous US Food and Drug Administration emergency use authorization (EUA) and laboratory-developed test (LDT) serologic assays have become available. The performance characteristics of these assays and their clinical utility continue to be defined in real time during this pandemic. The AACC convened a panel of experts from clinical chemistry, microbiology, and immunology laboratories; the in vitro diagnostics industry; and regulatory agencies to provide practical recommendations for implementation and interpretation of these serologic tests in clinical laboratories.

Content
The currently available EUA serologic tests and platforms, information on assay design, antibody classes including neutralizing antibodies, and the humoral immune responses to SARS-CoV-2 are discussed. Verification and validation of EUA and LDT assays are described, along with a quality management approach. Four indications for serologic testing are outlined. Recommendations for result interpretation, reporting comments, and the role of orthogonal testing are also presented.

Summary
This document aims to provide a comprehensive reference for laboratory professionals and healthcare workers to appropriately implement SARS-CoV-2 serologic assays in the clinical laboratory and to interpret test results during this pandemic. Given the more frequent occurrence of outbreaks associated with either vector-borne or respiratory pathogens, this document will be a useful resource in planning for similar scenarios in the future.
Consolidating identities in anonymous ego-centred collaboration networks
Authors: Gomide Janaina , Kling Hugo , Figueiredo Daniel 
Published: March 2021

Abstract
Individuals often appear with multiple names when considering large datasets collected from different sources, giving rise to the name ambiguities. Classical techniques that tackle this problem leverage personal information such as names and institutions. However, as privacy concerns continues to rise, Personally Identifiable Information (PII) may not be available in publicly released data. This work considers the synonym name ambiguity problem in anonymous ego-centred collaboration networks. The ego-centred collaboration network is generated from the individual’s profile and stripped of all PII. Using just the anonymous network, and no other side information, we propose an algorithm based on dominating sets to identify the different nodes that corresponds to the profile owner (synonyms). The proposed approach is applied to different datasets originating from profiles in DBLP and Google Scholar, showing an a relative high precision (e.g. 75% of profiles were perfectly mapped). This methodology indicates that ambiguous ego-centred networks have enough structural information to correctly identify synonyms of the individual.
“Only a Bird in a Gilded Cage”: Avianthropes and the Embodiment of the Canorographic Voice in Angela Carter’s “The Erl-King” andNights at the Circus
Authors: Paulusma Polly 
Published: March 2021

AbstractRenowned for her fiction, Angela Carter was also a folk singer in the 1960s, played English concertina, and cofounded a folk club. A newly unearthed archive of her notes, musical notations, and recordings provides a window into her folk song praxis. When juxtaposed with her diaries, album sleeve notes, and unpublished papers, a new understanding of Carter’s writing processes emerges. This essay explores her “canorographic” writing or “songful” writing, embodied in avianthropes: the bird-girls in “The Erl-King” and Fevvers in Nights at the Circus. I compare Child Ballad “Lady Isabel and the Elf-Knight,” Ovid’s Philomel, and Petrarch’s nightingale with Carter’s bird-women to show how her tropes transcode the singing voice into prose, disclosing the porous boundaries between literature and song and reimagining prose as performance.
Disturbance cue communication is shaped by emitter diet and receiver background risk in Trinidadian guppies
Authors: Goldman Jack A , Crane Adam L , Feyten Laurence E A , Collins Emily , Brown Grant E 
Published: March 2021

Abstract
In animal communication systems, individuals that detect a cue (i.e., “receivers”) are often influenced by characteristics of the cue emitter. For instance, in many species, receivers avoid chemical cues that are released by emitters experiencing disturbance. These chemical “disturbance cues” appear to benefit receivers by warning them about nearby danger, such as a predator’s approach. While the active ingredients in disturbance cues have been largely unexplored, by-products of metabolized protein are thought to play a role for some species. If so, the content (quality) and volume (quantity) of the emitter’s diet should affect their disturbance cues, thus altering how receivers perceive the cues and respond. Guppies Poecilia reticulata are a species known to discriminate among disturbance cues from different types of donors, but dietary variation has yet to be explored. In this study, we found evidence that diet quality and quantity can affect disturbance cues released by guppy emitters (i.e., experimental “donors”). Receivers discriminated between donor cue treatments, responding more strongly to cues from donors fed a protein-rich bloodworm diet (Experiment 1), as well as an overall larger diet (Experiment 2). We also found that receivers exposed to higher background risk were more sensitive to disturbance cue variation, with the strongest avoidance responses displayed by high-risk receivers toward disturbance cues from donors fed the high-quality diet. Therefore, diet, and perhaps protein specifically, affects either the concentration or composition of disturbance cues released by guppies. Such variation may be important in information signaling in social species like the guppy.
Management of chyle leaks following esophageal resection: a systematic review
Authors: Power Robert , Smyth Philip , Donlon Noel E , Nugent Timothy , Donohoe Claire L , Reynolds John V 
Published: March 2021

Summary

Background
Chyle leakage is an uncommon but potentially life-threatening complication following esophageal resections. The optimal management strategy is not clear, with a limited evidence base.

Methods
Searches were conducted up to 31 December 2020 on MEDLINE, Embase, and Web of Science for randomized trials or retrospective studies that evaluated the management of chyle leakage following esophageal resection. Two authors independently screened studies, extracted data, and assessed for bias. The protocol was prospectively registered on PROSPERO (CRD: 42021224895) and reported in accordance with preferred reporting items for systematic reviews and meta-analyses guidelines.

Results
A total of 530 citations were reviewed. Twenty-five studies, totaling 1016 patients met the inclusion criteria, including two low-quality clinical trials and 23 retrospective case series. Heterogeneity of study design and outcomes prevented meta-analysis. The overall incidence of chyle leak/fistula was 3.2%. Eighteen studies describe management of chyle leaks conservatively, 17 by surgical ligation of the thoracic duct, 5 by pleurodesis, and 6 described percutaneous lymphangiography with thoracic duct embolization or disruption.

Conclusions
The evidence base for optimal management of chyle leakage postesophagectomy is lacking, which may be related to its low incidence. There is a paucity of high-quality prospective studies directly comparing treatment modalities, but there is some low-certainty evidence that percutaneous approaches have reduced morbidity but lower efficacy compared with surgery. Further high-quality, prospective studies that compare interventions at different levels of severity are needed to determine the optimal approach to treatment.
Results of endovascular aortic arch repair using the Relay Branch system
Authors: Czerny Martin , Berger Tim , Kondov Stoyan , Siepe Matthias , Saint Lebes Bertrand , Mokrane Fatima , Rousseau Herve , Lescan Mario , Schlensak Christian , Andic Mateja , Hazenberg Constatijn , Bloemert-Tuin Trijntje , Braithwaite Sue , van Herwaarden Joost , Hyhlik-Dürr Alexander , Gosslau Yvonne , Pedro Luís Mendes , Amorim Pedro , Kuratani Toru , Cheng Stephen , Heijmen Robin , van der Weijde Emma , Pleban Eliza , Szopiński Piotr , Rylski Bartosz 
Published: March 2021

Abstract

OBJECTIVES
Our goal was to evaluate results of endovascular aortic arch repair using the Relay Branch system.

METHODS
Forty-three patients with thoracic aortic pathology involving the aortic arch have been treated with the Relay Branch system (Terumo Aortic, Sunrise, FL, USA) in 10 centres. We assessed in-hospital mortality, neurological injury, treatment success according to current reporting standards and the need for secondary interventions. In addition, outcome was analysed according to the underlying pathology: non-dissective disease versus residual aortic dissection (RAD) (defined as remaining dissection after previous type A repair, chronic type B aortic dissections).

RESULTS
In-hospital mortality was 9% (0% in patients with RAD). Disabling stroke occurred in 7% (0% in patients with RAD); non-disabling stroke occurred in 19% (7% in patients with RAD). Early type IA and B endoleak formation occurred in 4%. Median follow-up was 16 ± 18 months. During the follow-up period, 23% of the patients died. Aortic-related deaths were low (3% in patients with RAD).

CONCLUSIONS
The results of endovascular aortic arch repair using the Relay Branch system in a selected patient population with regard to technical success are good. In-hospital mortality is acceptable, the number of disabling strokes is low and technical success is high. Non-disabling stroke is a major concern, and every effort has to be taken to reduce this to a minimum. The best outcome is seen in patients with underlying RAD. Finally, more data are needed.
Leveraging clinical epigenetics in heart failure with preserved ejection fraction: a call for individualized therapies
Authors: Hamdani Nazha , Costantino Sarah , Mügge Andreas , Lebeche Djamel , Tschöpe Carsten , Thum Thomas , Paneni Francesco 
Published: March 2021

Abstract
Described as the ‘single largest unmet need in cardiovascular medicine’, heart failure with preserved ejection fraction (HFpEF) remains an untreatable disease currently representing 65% of new heart failure diagnoses. HFpEF is more frequent among women and associates with a poor prognosis and unsustainable healthcare costs. Moreover, the variability in HFpEF phenotypes amplifies complexity and difficulties in the approach. In this perspective, unveiling novel molecular targets is imperative. Epigenetic modifications—defined as changes of DNA, histones, and non-coding RNAs (ncRNAs)—represent a molecular framework through which the environment modulates gene expression. Epigenetic signals acquired over the lifetime lead to chromatin remodelling and affect transcriptional programmes underlying oxidative stress, inflammation, dysmetabolism, and maladaptive left ventricular remodelling, all conditions predisposing to HFpEF. The strong involvement of epigenetic signalling in this setting makes the epigenetic information relevant for diagnostic and therapeutic purposes in patients with HFpEF. The recent advances in high-throughput sequencing, computational epigenetics, and machine learning have enabled the identification of reliable epigenetic biomarkers in cardiovascular patients. Contrary to genetic tools, epigenetic biomarkers mirror the contribution of environmental cues and lifestyle changes and their reversible nature offers a promising opportunity to monitor disease states. The growing understanding of chromatin and ncRNAs biology has led to the development of several Food and Drug Administration approved ‘epidrugs’ (chromatin modifiers, mimics, anti-miRs) able to prevent transcriptional alterations underpinning left ventricular remodelling and HFpEF. In the present review, we discuss the importance of clinical epigenetics as a new tool to be employed for a personalized management of HFpEF.
Effectiveness of tailored intervention with a salutogenic approach to improve adherence in adults with hypertension: a non-randomized trial
Authors: Esquivel Garzón Natalia , Díaz Heredia Luz Patricia , Grisales Romero Hugo , Cañon-Montañez Wilson 
Published: March 2021

Abstract

Aims
Hypertension (HTN) is a chronic long-term, slowly progressing disease. For HTN control, management, and prevention of associated complications, adequate adherence to treatment is required. It has been proposed that tailored interventions to individual needs are required to address the phenomenon of adherence to treatment. However, studies evaluating the effects of tailored interventions to improve adherence are still scarce. The aim of this study is to evaluate the effectiveness of a tailored intervention using a salutogenic approach, to improve adherence in patients with HTN.

Methods and results
A non-randomized trial design was used in this study. Adult patients with HTN were allocated in two groups: tailored intervention (n = 75) and standard care (n = 78). The content of the tailored intervention was based on personal resources and elaboration of an action plan with objectives in agreement with the patients. Patient outcomes (treatment adherence, blood pressure) were assessed both at the beginning of the study and at the 4-week follow-up for the intervention group and the standard care group. The Treatment Adherence Questionnaire for Patients with Hypertension was used to measure adherence. The results of this study showed that the total score and each dimension of the adherence questionnaire (medications, diet, physical activity, weight control, stimulation, and stress relief) increased significantly in the experimental group compared with the control group (P &lt; 0.05). For the group assigned to tailored intervention, the delta score of the total adherence score increased in the final evaluation to 9.4 (95% CI = 8.60–10.28).

Conclusion
A tailored intervention with a salutogenic approach appears to be effective for improving adherence in patients with HTN. Randomized controlled trials are required to confirm the effect of tailored interventions in this type of population.
Lipoprotein (a) as a treatment target for cardiovascular disease prevention and related therapeutic strategies: a critical overview
Authors: Parthymos Ioannis , Kostapanos Michael S , Mikhailidis Dimitri P , Florentin Matilda 
Published: March 2021

AbstractAdvances in several fields of cardiovascular (CV) medicine have produced new treatments (e.g. to treat dyslipidaemia) that have proven efficacy in terms of reducing deaths and providing a better quality of life. However, the burden of CV disease (CVD) remains high. Thus, there is a need to search for new treatment targets. Lipoprotein (a) [Lp(a)] has emerged as a potential novel target since there is evidence that it contributes to CVD events. In this narrative review, we present the current evidence of the potential causal relationship between Lp(a) and CVD and discuss the likely magnitude of Lp(a) lowering required to produce a clinical benefit. We also consider current and investigational treatments targeting Lp(a), along with the potential cost of these interventions.
Highly effective proximate labeling in Drosophila
Authors: Zhang Bo , Zhang Yuanbing , Liu Ji-Long 
Published: March 2021

Abstract
The protein–protein interaction (PPI) is a basic strategy for life to operate. The analysis of PPIs in multicellular organisms is very important but extremely challenging because PPIs are particularly dynamic and variable among different development stages, tissues, cells, and even organelles. Therefore, understanding PPI needs a good resolution of time and space. More importantly, understanding in vivo PPI needs to be realized in situ. Proximity-based biotinylation combined with mass spectrometry (MS) has emerged as a powerful approach to study PPI networks and protein subcellular compartmentation. TurboID, the newly engineered promiscuous ligase, has been reported to label proximate proteins effectively in various species. In Drosophila, we systematically apply TurboID-mediated biotinylation in a wide range of developmental stages and tissues, and demonstrate the feasibility of TurboID-mediated labeling system in desired cell types. For a proof-of-principle, we use the TurboID-mediated biotinylation coupled with MS to distinguish CTP synthase with or without the ability to form filamentous cytoophidia, retrieving two distinct sets of proximate proteomes. Therefore, this makes it possible to map PPIs in vivo and in situ at a defined spatiotemporal resolution, and demonstrates a referable resource for cytoophidium proteome in Drosophila.
A case of convergent-gene interference in the budding yeast knockout library causing chromosome instability
Authors: Gordon Molly R , Zhu Jin , Qu Victoria , Li Rong 
Published: March 2021

Abstract
To maintain genome stability, organisms depend on faithful chromosome segregation, a process affected by diverse genetic pathways, some of which are not directly linked to mitosis. In this study, we set out to explore one such pathway represented by an undercharacterized gene, SNO1, identified previously in screens of the yeast knockout (YKO) library for mitotic fidelity genes. We found that the causative factor increasing mitotic error rate in the sno1Δ mutant is not loss of the Sno1 protein, but rather perturbation to the mRNA of the neighboring convergent gene, CTF13, encoding an essential component for forming the yeast kinetochore. This is caused by a combination of the Kanamycin resistance gene and the transcriptional terminator used in the YKO library affecting the CTF13 mRNA level and quality . We further provide a list of gene pairs potentially subjected to this artifact, which may be useful for accurate phenotypic interpretation of YKO mutants.
Gene Duplications Trace Mitochondria to the Onset of Eukaryote Complexity
Authors: Tria Fernando D K , Brueckner Julia , Skejo Josip , Xavier Joana C , Kapust Nils , Knopp Michael , Wimmer Jessica L E , Nagies Falk S P , Zimorski Verena , Gould Sven B , Garg Sriram G , Martin William F 
Published: March 2021

AbstractThe last eukaryote common ancestor (LECA) possessed mitochondria and all key traits that make eukaryotic cells more complex than their prokaryotic ancestors, yet the timing of mitochondrial acquisition and the role of mitochondria in the origin of eukaryote complexity remain debated. Here, we report evidence from gene duplications in LECA indicating an early origin of mitochondria. Among 163,545 duplications in 24,571 gene trees spanning 150 sequenced eukaryotic genomes, we identify 713 gene duplication events that occurred in LECA. LECA’s bacterial-derived genes include numerous mitochondrial functions and were duplicated significantly more often than archaeal-derived and eukaryote-specific genes. The surplus of bacterial-derived duplications in LECA most likely reflects the serial copying of genes from the mitochondrial endosymbiont to the archaeal host’s chromosomes. Clustering, phylogenies and likelihood ratio tests for 22.4 million genes from 5,655 prokaryotic and 150 eukaryotic genomes reveal no evidence for lineage-specific gene acquisitions in eukaryotes, except from the plastid in the plant lineage. That finding, and the functions of bacterial genes duplicated in LECA, suggests that the bacterial genes in eukaryotes are acquisitions from the mitochondrion, followed by vertical gene evolution and differential loss across eukaryotic lineages, flanked by concomitant lateral gene transfer among prokaryotes. Overall, the data indicate that recurrent gene transfer via the copying of genes from a resident mitochondrial endosymbiont to archaeal host chromosomes preceded the onset of eukaryotic cellular complexity, favoring mitochondria-early over mitochondria-late hypotheses for eukaryote origin.
Delirium and Delirium Severity Predict the Trajectory of the Hierarchical Assessment of Balance and Mobility in Hospitalized Older People: Findings From the DECIDE Study
Authors: Richardson Sarah , Murray James , Davis Daniel , Stephan Blossom C M , Robinson Louise , Brayne Carol , Barnes Linda , Parker Stuart , Sayer Avan A , Dodds Richard M , Allan Louise 
Published: March 2021

Abstract

Background
Delirium is common, distressing, and associated with poor outcomes. Despite this, delirium remains poorly recognized, resulting in worse outcomes. There is an urgent need for methods to objectively assess for delirium. Physical function has been proposed as a potential surrogate marker, but few studies have monitored physical function in the context of delirium. We examined if trajectories of physical function are affected by the presence and severity of delirium in a representative sample of hospitalized participants older than 65 years.

Method
During hospital admissions in 2016, we assessed participants from the Delirium and Cognitive Impact in Dementia study daily for delirium and physical function, using the Hierarchical Assessment of Balance and Mobility (HABAM). We used linear mixed models to assess the effect of delirium and delirium severity during admission on HABAM trajectory.

Results
Of 178 participants, 58 experienced delirium during admission. Median HABAM scores in those with delirium were significantly higher (indicating worse mobility) than those without delirium. Modeling HABAM trajectories, HABAM scores at first assessment were worse in those with delirium than those without, by 0.76 (95% CI: 0.49–1.04) points. Participants with severe delirium experienced a much greater perturbance in their physical function, with an even lower value at first assessment and slower subsequent improvement.

Conclusions
Physical function was worse in those with delirium compared to without. This supports the assertion that motor disturbances are a core feature of delirium and monitoring physical function, using a tool such as the HABAM, may have clinical utility as a surrogate marker for delirium and its resolution.
Names of Feelings in the Dictionary
Authors: Iordanskaja Lidija , Mel’čuk Igor 
Published: March 2021

AbstractThe paper deals with words that denote feelings rather than with feelings as such. It proposes the strictly lexicographic description of some names of ‘psyche-induced feelings1’ [= ‘feelings2’], such as joy or amazement, in contrast to the names of ‘body-induced feelings1’ [= ‘sensations’], such as hunger and tiredness. This description is based on the semantic prime ‘feel1’, which itself is explicated through a naïve model of the human psyche. Our theoretical and descriptive framework is the Explanatory Combinatorial Dictionary: its main principles, the notions of lexical unit (described by a lexical entry) and vocable (described by a lexical superentry), and the three major zones of a lexical entry. A tripartite general schema of the lexicographic definition of a feeling2 name is proposed: the central (= generic) component, the Stimulus component, and the Effect component. According to the Stimulus component, four major classes of feeling2 names are distinguished: names of reactions to facts, to thoughts, to beliefs, and to wishes. These classes are illustrated with the definitions of several English feeling2 names. A complete lexical entry for the feeling2 name anger(N)1 is given.