bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac Microvascular Endothelial Cells in Pressure Overload–Induced Heart Disease
Authors: Trenson Sander , Hermans Hadewich , Craps Sander , Pokreisz Peter , de Zeeuw Pauline , Van Wauwe Jore , Gillijns Hilde , Veltman Denise , Wei Fangfei , Caluwé Ellen , Gijsbers Rik , Baatsen Pieter , Staessen Jan A. , Ghesquiere Bart , Carmeliet Peter , Rega Filip , Meuris Bart , Meyns Bart , Oosterlinck Wouter , Duchenne Jürgen , Goetschalckx Kaatje , Voigt Jens-Uwe , Herregods Marie-Christine , Herijgers Paul , Luttun Aernout , Janssens Stefan 
Published: January 2021

Background:
Chronic pressure overload predisposes to heart failure, but the pathogenic role of microvascular endothelial cells (MiVEC) remains unknown. We characterized transcriptional, metabolic, and functional adaptation of cardiac MiVEC to pressure overload in mice and patients with aortic stenosis (AS).

Methods:

In
Tie2-Gfp
mice subjected to transverse aortic constriction or sham surgery, we performed RNA sequencing of isolated cardiac
Gfp
+
-MiVEC and validated the signature in freshly isolated MiVEC from left ventricle outflow tract and right atrium of patients with AS. We next compared their angiogenic and metabolic profiles and finally correlated molecular and pathological signatures with clinical phenotypes of 42 patients with AS (50% women).

Results:

In mice, transverse aortic constriction induced progressive systolic dysfunction, fibrosis, and reduced microvascular density. After 10 weeks, 25 genes predominantly involved in matrix-regulation were >2-fold upregulated in isolated MiVEC. Increased transcript levels of
Cartilage Intermediate Layer Protein
(
Cilp
),
Thrombospondin-4
,
Adamtsl-2
, and
Collagen1a1
were confirmed by quantitative reverse transcription polymerase chain reaction and recapitulated in left ventricle outflow tract-derived MiVEC of AS (
P
<0.05 versus right atrium-MiVEC). Fatty acid oxidation increased >2-fold in left ventricle outflow tract-MiVEC, proline content by 130% (median, IQR, 58%–474%;
P
=0.008) and procollagen secretion by 85% (mean [95% CI, 16%–154%];
P
<0.05 versus right atrium-MiVEC for all). The altered transcriptome in left ventricle outflow tract-MiVEC was associated with impaired 2-dimensional-vascular network formation and 3-dimensional-spheroid sprouting (
P
<0.05 versus right atrium-MiVEC), profibrotic ultrastructural changes, and impaired diastolic left ventricle function, capillary density and functional status, especially in female AS.

Conclusions:
Pressure overload induces major transcriptional and metabolic adaptations in cardiac MiVEC resulting in excess interstitial fibrosis and impaired angiogenesis. Molecular rewiring of MiVEC is worse in women, compromises functional status, and identifies novel targets for intervention.
Resting Heartbeat Complexity Predicts All‐Cause and Cardiorespiratory Mortality in Middle‐ to Older‐Aged Adults From the UK Biobank
Authors: Gao Lei , Gaba Arlen , Cui Longchang , Yang Hui‐Wen , Saxena Richa , Scheer Frank A. J. L. , Akeju Oluwaseun , Rutter Martin K. , Lo Men‐Tzung , Hu Kun , Li Peng 
Published: January 2021

Background
Spontaneous heart rate fluctuations contain rich information related to health and illness in terms of physiological complexity, an accepted indicator of plasticity and adaptability. However, it is challenging to make inferences on complexity from shorter, more practical epochs of data. Distribution entropy (DistEn) is a recently introduced complexity measure that is designed specifically for shorter duration heartbeat recordings. We hypothesized that reduced DistEn predicted increased mortality in a large population cohort.

Method and Results
The prognostic value of DistEn was examined in 7631 middle‐older–aged UK Biobank participants who had 2‐minute resting ECGs conducted (mean age, 59.5 years; 60.4% women). During a median follow‐up period of 7.8 years, 451 (5.9%) participants died. In Cox proportional hazards models with adjustment for demographics, lifestyle factors, physical activity, cardiovascular risks, and comorbidities, for each 1‐SD decrease in DistEn, the risk increased by 36%, 56%, and 73% for all‐cause, cardiovascular, and respiratory disease–related mortality, respectively. These effect sizes were equivalent to the risk of death from being >5 years older, having been a former smoker, or having diabetes mellitus. Lower DistEn was most predictive of death in those <55 years with a prior myocardial infarction, representing an additional 56% risk for mortality compared with older participants without prior myocardial infarction. These observations remained after controlling for traditional mortality predictors, resting heart rate, and heart rate variability.

Conclusions
Resting heartbeat complexity from short, resting ECGs was independently associated with mortality in middle‐ to older‐aged adults. These risks appear most pronounced in middle‐aged participants with prior MI, and may uniquely contribute to mortality risk screening.
The Discourses of Identity in Hellenistic Erythrai: Institutions, Rhetoric, Honour and Reciprocity
Authors: Liddel Peter 
Published: January 2021

Abstract
Recent research in the field of New Institutionalist analysis has developed the view that institutions are grounded not only upon authoritative rules but also upon accepted practices and narratives. In this paper I am interested in the ways in which honorific practices and accounts of identity set out in ancient Greek inscriptions contribute towards the persistence of polis institutions in the Hellenistic period. A diachronic survey of Erythraian inscriptions of the classical and Hellenistic periods gives an impression of the adaptation and proliferation of forms of discourse established in the classical period. It demonstrates the ongoing prominence of the rhetoric of identity in conversations that went on not only between peer polities and within real or imagined kinship groups but also in negotiations between powerful and weak state entities and in inward-facing discourses on euergetism.
Non-refoulement Principle and Its Application to Refugees and Asylum Seekers Who Have Committed Offences in Africa
Authors: Mujuzi Jamil Ddamulira 
Published: January 2021

Abstract
The 1951 Convention Relating to the Status of Refugees and the 1969 African Union Convention Governing the Specific Aspects of Refugee Problems in Africa have been ratified by many African States. These treaties deal with, inter alia, the principle of non-refoulement generally and the protection of asylum seekers or refugees convicted of offences. Some States in Eastern and Southern Africa have also enacted domestic legislation giving effect to these treaties and the principle of non-refoulement is provided for in most of these pieces of legislation, albeit sometimes in different ways. This article assesses legislation and case law from Eastern and Southern African States to demonstrate how courts have dealt with the principle of non-refoulement in the context of refugees and/or asylum seekers who have been convicted of offences. It also considers relevant legislation and case law prohibiting extradition if there are grounds to believe that the extradited person could be subjected to torture in a receiving State.
The Value of the Samaritan Versions for the Textual History of the Samaritan Pentateuch
Authors: Schorch Stefan 
Published: January 2021

Abstract
The Samaritan Aramaic Targum presents an extremely literal translation of SP, but the measure of literalness varies between different manuscripts. Further textual differences between these manuscripts can be related to different Hebrew Vorlagen, or to different interpretations of one and the same Hebrew Vorlage. It can thus be concluded that the Samaritan Targum tradition does not represent a single Aramaic translation of SP, but rather consists of several translations, based on different Hebrew Vorlagen. SAT and also the Samaritan Arabic translation are therefore important witnesses for the textual history of SP, relating to the written transmission of SP in the period before the 12th century CE, for which no Hebrew manuscripts are extant, and also to the Samaritan vocalization. This evidence demonstrates that the textual variety found in the Hebrew manuscripts of SP was already present in the transmission of SP between the 1st and the 11th century CE.
Emerging New Psychiatric Symptoms and the Worsening of Pre-existing Mental Disorders during the COVID-19 Pandemic: A Canadian Multisite Study: Nouveaux symptômes psychiatriques émergents et détérioration des troubles mentaux préexistants durant la pandémie de la COVID-19: une étude canadienne multisite
Authors: Robillard Rebecca , Daros Alexander R. , Phillips Jennifer L. , Porteous Meggan , Saad Mysa , Pennestri Marie-Helene , Kendzerska Tetyana , Edwards Jodi D. , Solomonova Elizaveta , Bhatla Rajiv , Godbout Roger , Kaminsky Zachary , Boafo Addo , Quilty Lena C. 
Published: January 2021

Background: The coronavirus disease 2019 (COVID-19) pandemic has caused global disruptions with serious psychological impacts. This study investigated the emergence of new psychiatric symptoms and the worsening of pre-existing mental disorders during the COVID-19 pandemic, identified factors associated with psychological worsening, and assessed changes in mental health service use. Methods: An online survey was circulated between April 3 and June 23, 2020. Respondents were asked to complete mental health questionnaires based on 2 time referents: currently (i.e., during the outbreak) and in the month preceding the outbreak. A total of 4,294 Canadians between 16 and 99 years of age were subdivided based on the presence of self-reported psychiatric diagnoses. Results: The proportion of respondents without prior psychiatric history who screened positive for generalized anxiety disorder and depression increased by 12% and 29%, respectively, during the outbreak. Occurrences of clinically important worsening in anxiety, depression, and suicidal ideation symptoms relative to pre-outbreak estimates were significantly higher in those with psychiatric diagnoses. Furthermore, 15% to 19% of respondents reported increased alcohol or cannabis use. Worse psychological changes relative to pre-outbreak estimate were associated with female sex, younger age, lower income, poorer coping skills, multiple psychiatric comorbidities, previous trauma exposure, deteriorating physical health, poorer family relationships, and lower exercising. Reductions in mental health care were associated with increased suicidal ideation. Conclusion: The worsening in mental health symptoms and the decline in access to care call for the urgent development of adapted interventions targeting both new mental disorders and pre-existing psychiatric conditions affected by the COVID-19 pandemic.
Preparing for Implementation Within Therapy Services for People With Dementia: Exploring Expectations and Experiences Among Service Providers
Authors: Culph Jennifer , Clemson Lindy , Jeon Yun-Hee , Scanlan Justin , Laver Kate 
Published: January 2021

Background: This study examined how occupational therapists, nurses, and their managers within different organizational contexts in the Australian health and aged care system prepare for implementation. The program being implemented was the Care of People with dementia in their Environment (COPE) program, a community reablement program for people with dementia and their carers. Methods: Qualitative data from 29 in-depth interviews were collected from occupational therapists, nurses, and their managers. Recruitment ensured a variety of organizational contexts were included. Thematic analysis was used to capture key themes. Results: Themes include innovation in a time of instability and uncertainty, values that align with the innovation, shifting the day-to-day practice, and confidence in new specialized skills. Conclusion: Organizations need to carefully consider internal and external contexts when planning implementation efforts. Study findings have informed plans for embedding delivery of the program within the health and aged care sector.
Diagnostic Neuroradiology Subspecialty Training: 1 Versus 2 Years; the Canadian Perspective
Authors: Maralani Pejman Jabehdar , Shewchuk Jason R. , Joshi Manish , Ribeiro Luciana , Carpio-O’Donovan Raquel del , Landry David , Sharma Manas , Zakhari Nader , Symons Sean , Morrish William , Schmidt Matthias 
Published: January 2021

Background: Canada began a national reform of its post-graduate medical education training programs to a Competence By Design (CBD) model. Trends from accredited neuroradiology programs from the past 10 years were investigated to inform educators and stakeholders for this process. Methods: A 13-question electronic survey was sent to program directors of all 8 accredited neuroradiology training programs in Canada. Data was requested for each year on the 2008-2019 graduating classes. Questions pertained to program enrolment; program completion; post-training employment; and the sufficiency of 1-year training programs. Results: Response rate was 100%. Over the timeframe studied, the 2-year programs increased in size ( P = 0.007), while the 1-year programs remained steady ( P = 0.27). 12.2% of trainees enrolled in the 2-year program dropped out after 1 year, and were considered 1-year trainees thereafter. A higher proportion of 2-year trainees obtain positions within academic institutions (89.5 vs 67.2%, P = 0.0007), whereas a higher proportion of 1-year trainees obtain positions within non-academic institutions (29.3 vs 8.1%, P = 0.0007). A higher proportion of those with Canadian board certification in diagnostic radiology who completed a 2-year program obtained a position within a Canadian academic institution compared to non-certified 2-year trainees ( P < 0.001). 71.4% of program directors agreed that a 1-year program was sufficient for non-academic staff positions. Conclusion: The length of the training program has significant impact on employment in academic vs non-academic institutions. This information can be used to guide the upcoming CBD initiative for neuroradiology programs.
Reception Social Services for Migration Families in Italy: Strength, Critical Aspects, and Challenges
Authors: Coppola Ilaria , Rania Nadia , Pinna Laura 
Published: January 2021

Purpose: The objective of this research is to investigate the perception that migrant families and social workers have of their relationship and of the services offered and received in the reception path. Method: The qualitative research involved thirty parents with semi-structured family interviews and their twelve reference social workers, with focus group. The collected materials were transcribed verbatim and analysed through the grounded theory, using the NVivo software. Results: Results highlighted strengths, critical issues and challenges, some shared between social workers and families, like the sense of mutual trust and the perception of abandonment and loneliness. Others were expressed only by social workers as a greater attention to families, or by families as the possibility of social-health services. Conclusion: Many of the practical implications have been discussed such as the supervision of social workers, the widespread hospitality and the development of skills of social workers but also of families for social and work integration.
Atypical Outcomes of Nasal and Lip Appearance After Unilateral Cleft Lip Repair: Judgment by Professionals, Patients, and Laypeople
Authors: Tan Robin A. , Mulder Frans J. , Schwirtz Roderic M. F. , Mosmuller David G. M. , De Vet Henrica C. W. , Griot J. Peter W. Don 
Published: January 2021

Objective: To gain more insight into the assessment of “atypical” nasal and lip appearance outcomes compared to “typical” appearance outcomes after unilateral cleft lip and palate (UCLP) repair, when judged by professionals, patients with repaired UCLP, and laypeople. Design: An online survey containing 3 series of photographs with various degrees of “typical” and “atypical” nasal and lip appearance outcomes after UCLP repair was sent to 30 professionals, 30 patients with repaired UCLP, and 50 laypeople in 2 countries. Participants were instructed to rank the photographs from excellent to poor based on overall appearance. Mean rank positions of photographs were analyzed and differences in mean rank score between “typical” and “atypical” results were assessed using a T-test. Agreement of ranking between the 3 groups was assessed with an analysis of variance analysis. Setting: Amsterdam UMC, location VUmc, Netherlands and Boston Children’s Hospital, Boston, USA. Patients: Photographs of 6- to 18-year-old patients with repaired UCLP. Results: “Atypical” appearance outcomes were ranked significantly less favorably (small nostril: P = 0.00; low vermillion border: P = 0.02; whistling deformity: P = 0.00) compared to “typical” outcomes. Difference between professionals, patients and laypeople in rank positioning the photographs was not statistically significant ( P = 0.89). Conclusions: Noses with a smaller nostril and lips containing a whistling deformity were perceived as poorer outcome compared to the “typical” results. Professionals, patients, and laypeople are in agreement when assessing these outcomes.
Incidence of microcytosis in hyperthyroid cats referred for radioiodine treatment
Authors: Gil-Morales Claudia , Costa Marta , Tennant Kathleen , Hibbert Angie 
Published: January 2021

Objectives The study aimed to document the incidence of erythrocyte microcytosis in a population of hyperthyroid cats referred for radioiodine (RAI) treatment. Microcytosis has been observed but not described in feline hyperthyroid patients and is associated with hyperthyroidism in humans. Methods Retrospective clinicopathological data were collected for cats undergoing RAI between January and December 2017. Microcytosis was defined as mean cell volume (MCV) <41.3 fl using the ADVIA 2120 haematology analyser (Siemens) and identified on blood smear examination by a haematology laboratory scientist or board-certified specialist in veterinary clinical pathology. Hyperthyroidism was classified as mild (total thyroxine [TT4] 60–124.9 nmol/l), moderate (TT4 125–250 nmol/l) or severe (TT4 ⩾251 nmol/l) immediately before RAI. Data were analysed descriptively and using a Pearson correlation coefficient to test the relationship between TT4 and microcytosis, and time elapsed between first diagnosis and MCV. Results There were 41 female and 37 male cats with an age range of 7.2–20.8 years. Most cats were non-pedigree (98.7%). Microcytosis (median MCV 39.8 fl, interquartile range 32.3–41.2) was present in 29.5% (23/78) of the cats. Of the 23 microcytic samples, 86.9% (20/23) were confirmed as such on smear examination. Of mildly, moderately and severely hyperthyroid cats, 23% (6/26), 28.1% (9/32) and 40% (8/20) were microcytic, respectively. Two microcytic cats had low red blood cell counts (<6 × 1012/l) and low haemoglobin concentration (<8.2 g/dl). There was no correlation between TT4 or time elapsed from first diagnosis and MCV. Microcytosis resolved in 77.7% (7/9) of cases with follow-up. One microcytic cat had significant comorbidities (portosystemic shunt). Conclusions and relevance Microcytosis was present in a significant proportion of hyperthyroid cats, most without clinically significant comorbidities, and resolved in some following RAI.
Patient preferences for telehealth services in a large multispecialty practice
Authors: Ebbert Jon O , Ramar Priya , Tulledge-Scheitel Sidna M , Njeru Jane W , Rosedahl Jordan K , Roellinger Daniel , Philpot Lindsey M 
Published: January 2021

Introduction Telehealth service provision has accelerated during the Coronavirus disease 2019 (COVID-19) pandemic. As the pandemic continues, clinical practices have discovered ways to resume operations. Opportunities exist to understand patient preferences for telehealth clinical services and to tailor offerings to different demographic groups. Methods We conducted a survey of patients receiving telehealth services through our outpatient practice to understand the types of healthcare services for which patients report preferences for telehealth. Results We received 551 survey responses (response rate = 20.8%; 551/2650). More than half of patients indicated being ‘very likely’ to use telehealth services to refill medication(s) (67.3%), prepare for an upcoming visit (66.1%), review test results (60.3%), or receive education (54.2%). Males had lower odds of preferring telehealth services for reviewing test results (odds ratio (OR) = 0.57; 95% confidence interval (CI): 0.34–0.94) or mental health issues (OR = 0.54; 95% CI: 0.38–0.77). Respondents who received a video visit were significantly more likely than those who received a telephone visit to report preferences for using telehealth for education, care plan discussions, long-term health issues, and mental health. Discussion Patient preferences for telehealth services vary by services provided and respondent demographics. Experience with telehealth increases the likelihood for future use of these services.
Turkish Version of the Test Your Memory (TYM-TR) as a Screening Tool in Memory Clinics
Authors: Sadeh Reza Naghdi , Farhang Sara , Özkan Serhat , Khamnei Hossein Jabbari , Yenilmez Çınar , Maviş İlknur , Akarsu Ozlem , Adapınar Demet Özbabalık 
Published: January 2021

Introduction: This study compared the Turkish version of Test Your Memory (TYM) MMSE (Mini-Mental State Examination) and CDT (Clock Drawing Test) in patients with neurocognitive disorder. Methods: After a thorough medical workup, patients with a diagnosis of neurocognitive disorder were enrolled. A cross-sectional design was used to compare the TYM results with those of MMSE and CDT. Results: This study was conducted on 100 patients, including 46 males and 54 females, aged 52 to 86. The majority of patients were diagnosed with vascular neurocognitive disorder. The z-score of TYM-TR was significantly lower in the domains of registration, recall, visuospatial, and total score. The same results were achieved when CDT was added to MMSE. The same pattern was observed separately for those who were diagnosed with a mild or major neurocognitive disorder. Conclusion: Patients’ cognitive deficits might be more evident when measured by the TYM-TR compared to the MMSE.