bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bibliometric and Visual Analysis of Vascular Calcification Research
Authors: Dong Qian , Liang Qingchun , Chen Ying , Li Jinhe , Lu Lihe , Huang Xiongqing , Zhou Qin 
Published: July 2021

Background: Extensive studies related to vascular calcification (VC) were conducted in recent years. However, no bibliometric analysis has systematically investigated this topic. Our study aimed to determine the hotspots and frontiers of VC research in the past decade and provide a reference for future scientific research directions and decision-making in the VC field.Methods: VC studies were acquired from the Web of Science Core Collection. Bibliometric and visual analyses were performed using CiteSpace, VOSviewer, and Microsoft Excel software.Results: A total of 8,238 English articles on VC research published in 2011–2020 were obtained. In the past decade, annual publications and citations showed a significant growth trend, especially in 2018–2020. The most productive country, institution, journal and author are the United States, the University of California System, PLOS ONE, and Budoff MJ, respectively. The most frequently cited country, journal, and author are the United States, Journal of the American College of Cardiology, and Floege J, respectively. “Vascular calcification,” “atherosclerosis,” “chronic kidney disease,” and “cardiovascular disease” are the primary keywords. The burst keywords “revascularization,” “calciprotein particle,” “microRNA,” and “microcalcification” are speculated to be the research frontiers.Conclusion: The main research hotspots in the VC field are the molecular mechanisms and prognosis of VC in patients with chronic kidney disease or cardiovascular disease. In addition, endovascular therapy and the development of new drugs targeting signal pathways for VC will become the focus of future research. Moreover, non-coding RNAs related to the diagnosis and treatment of VC are great research prospects.
Discovery of a New CDK4/6 and PI3K/AKT Multiple Kinase Inhibitor Aminoquinol for the Treatment of Hepatocellular Carcinoma
Authors: Xia Zhong-Kun , Wang Wei , Qiu Jian-Ge , Shi Xi-Nan , Li Hong-Jian , Chen Rong , Ke Kun-Bin , Dong Chao , Zhu Ying , Wu Shi-Guo , Zhang Rong-Ping , Meng Zhuo-Ran , Zhao Hui , Gu Peng , Leung Kwong-Sak , Wong Man-Hon , Liu Xiao-Dong , Zhou Feng-Mei , Zhang Jian-Ying , Yao Ya-Ting , Wang Si-Jia , Zhang Chun-Yang , Qin Yan-Ru , Lin Marie Chia-mi , Jiang Bing-Hua 
Published: July 2021

Background:Hepatocellular carcinoma (HCC) is a lethal malignancy lacking effective treatment. The Cyclin-dependent kinases 4/6 (CDK4/6) and PI3K/AKT signal pathways play pivotal roles in carcinogenesis and are promising therapeutic targets for HCC. Here we identified a new CDK4/6 and PI3K/AKT multi-kinase inhibitor for the treatment of HCC.Methods:Using a repurposing and ensemble docking methodology, we screened a library of worldwide approved drugs to identify candidate CDK4/6 inhibitors. By MTT, apoptosis, and flow cytometry analysis, we investigated the effects of candidate drug in reducing cell-viability,inducing apoptosis, and causing cell-cycle arrest. The drug combination and thermal proteomic profiling (TPP) method were used to investigate whether the candidate drug produced antagonistic effect. Thein vivoanti-cancer effect was performed in BALB/C nude mice subcutaneously xenografted with Huh7 cells.Results:We demonstrated for the first time that the anti-plasmodium drug aminoquinol is a new CDK4/6 and PI3K/AKT inhibitor. Aminoquinol significantly decreased cell viability, induced apoptosis, increased the percentage of cells in G1 phase. Drug combination screening indicated that aminoquinol could produce antagonistic effect with the PI3K inhibitor LY294002. TPP analysis confirmed that aminoquinol significantly stabilized CDK4, CDK6, PI3K and AKT proteins. Finally,in vivostudy in Huh7 cells xenografted nude mice demonstrated that aminoquinol exhibited strong anti-tumor activity, comparable to that of the leading cancer drug 5-fluorouracil with the combination treatment showed the highest therapeutic effect.Conclusion:The present study indicates for the first time the discovery of a new CDK4/6 and PI3K/AKT multi-kinase inhibitor aminoquinol. It could be used alone or as a combination therapeutic strategy for the treatment of HCC.
A Metabolic Pattern in Healthy Subjects Given a Single Dose of Metformin: A Metabolomics Approach
Authors: Dahabiyeh Lina A. , Mujammami Muhammad , Arafat Tawfiq , Benabdelkamel Hicham , Alfadda Assim A. , Abdel Rahman Anas M. 
Published: July 2021

Metformin is a widely prescribed medication for the treatment of type 2 diabetes mellitus (T2DM). It possesses effective roles in various disorders, including cancer, dyslipidemia, and obesity. However, the underlying mechanisms of metformin's multiple benefits are not fully understood. Herein, a mass spectrometry-based untargeted metabolomics approach was used to investigate the metabolic changes associated with the administration of a single dose of metformin in the plasma of 26 healthy subjects at five-time points; pre-dose, before the maximum concentration of metformin (Cmax), Cmax, after Cmax, and 36 h post-dose. A total of 111 metabolites involved in various biochemical processes were perturbed, with branched-chain amino acid (BCAA) being the most significantly altered pathway. Additionally, the Pearson similarity test revealed that 63 metabolites showed a change in their levels dependent on metformin level. Out of these 63, the level of 36 metabolites was significantly altered by metformin. Significantly altered metformin-dependent metabolites, including hydroxymethyl uracil, propionic acid, glycerophospholipids, and eicosanoids, pointed to fundamental biochemical processes such as lipid network signaling, energy homeostasis, DNA lesion repair mechanisms, and gut microbiota functions that could be linked to the multiple beneficial roles of metformin. Thus, the distinctive metabolic pattern linked to metformin administration can be used as a metabolic signature to predict the potential effect and mechanism of actions of new chemical entities during drug development.
Gold Nanoparticles Modified With Polyethyleneimine Disturbed the Activity of Drug-Metabolic Enzymes and Induced Inflammation-Mediated Liver Injury in Mice
Authors: Chen Hanqing , Zhou Shuang , Zhu Meilin , Wang Bing , Chen Wei , Zheng Lingna , Wang Meng , Feng Weiyue 
Published: July 2021

Gold nanoparticles (GNPs) have been used as a potential bioactive platform for drug delivery due to their unique optical and thermal characteristics. Liver is the main organ in orchestrating physiological homeostasis through metabolization of drugs and detoxification of exogenous substances. Therefore, it is crucial to deeply understand the mechanism of nanoparticle–liver interaction and the potential hepatic effects of GNPs in vivo. In this study, we studied the hepatic impacts of the intravenously injected polyethyleneimine (PEI)-modified GNPs (PEI-GNPs) on the expression of hepatic drug-metabolic enzymes and sterol responsive element binding protein 1c (SREBP-1c)-mediated de novo lipogenesis in mice for 24 h and 1 week. PEI-GNP accumulation in the liver is associated with increased liver inflammation, as evidenced by the gene expression of pro-inflammatory cytokines. Moreover, the GNP-induced hepatotoxicity in mice is partly due to liver inflammation–triggered disruption in the function of drug-metabolic enzymes, including hepatic uptake and efflux transporters, cytochrome P450 (CYP450), and UDP-glucuronosyltransferases (UGTs). The study provides evidence that it is necessary to consider the nanomaterial–liver interaction and manipulate the surface chemistry of GNPs prior to biomedical application of nanoparticles.
Making Childhood Obesity a Priority: A Qualitative Study of Healthcare Professionals' Perspectives on Facilitating Communication and Improving Treatment
Authors: Serban Costela Lacrimioara , Putnoky Salomeia , Ek Anna , Eli Karin , Nowicka Paulina , Chirita-Emandi Adela 
Published: July 2021

In Romania, one in four children has excess weight. Because childhood obesity is a sensitive topic, many healthcare professionals find it difficult to discuss children's excess weight with parents. This study aims to identify barriers and facilitators in childhood obesity-related communication, as perceived by healthcare professionals in Romania. As part of the STOP project, healthcare professionals (family physicians, pediatricians, and dieticians) who treat children with excess weight were invited to a telephone interview. The semi-structured questions were translated from a questionnaire previously used at the Swedish study site of the STOP project. Interviews were transcribed and then used for thematic analysis. Fifteen doctors and three dieticians (16 females and 2 males), with average 18.2 ± 10.1 years of experience, were interviewed. Four main themes were identified. Professionals reported that when children began experiencing obesity-related stigma or comorbidities, this became the tipping point of weight excess, where parents felt motivated to begin treatment. Barriers in communication were part of several layers of distrust, recognized as tension between professionals and caregivers due to conflicting beliefs about excess weight, as well as lack of trust in medical studies. Most respondents felt confident using models of good practice, consisting of a gentle approach and patient-centered care. Nonetheless, professionals noted systemic barriers due to a referral system and allocation of clinical time that hinder obesity treatment. They suggested that lack of specialized centers and inadequate education of healthcare professional conveys the system does not prioritize obesity treatment and prevention. The interviewed Romanian doctors and dieticians identified patient-centered care as key to treating children with obesity and building trust with their caregivers. Howevertheir efforts are hindered by healthcare system barriers, including the lack of specialized centers, training, and a referral system. The findings therefore suggest that, to improve childhood obesity prevention and treatment, systemic barriers should be addressed.Trial Registration:ClinicalTrials.gov, NCT03800823; 11 Jan 2019.
How Demanding Is Volunteer Work at a Crisis Line? An Assessment of Work- and Organization-Related Demands and the Relation With Distress and Intention to Leave
Authors: Willems Renate C. W. J. , Drossaert Constance H. C. , Miedema Harald S. , Bohlmeijer Ernst T. 
Published: July 2021

Background:Crisis line services, run by volunteers, offer a listening ear 24/7 to people who cannot or do not want to use professional help. Although previous studies have identified various potential stressors crisis line volunteers face, as yet a comprehensive assessment is lacking with regards to the frequency and perceived stressfulness of work- and organization-related demands, and their relationship with distress and a volunteer's intention to leave.Objective:To identify the frequency and impact of particular stressful situations (demands). In addition, to examine the extent to which these demands are associated with volunteers' demographics, distress and intention to leave the crisis line service.Method:In a cross-sectional study among 543 volunteers of a Dutch crisis line service the participants filled out a questionnaire about their experience of a large number of work- and organization-related demands and their perceived stressfulness. To calculate the impact of demands, the occurrence and stressfulness were multiplied. In addition, work-related distress, intention to leave the crisis line service as well as a number of demographics and work-related characteristics were assessed.Results:Work-related demands with the highest impact on volunteers were calls from people with psychiatric problems and suicidal intentions. “Having no time for a break” was the organization-related demand with the highest impact on volunteers. Eighteen percentage of the volunteers scored moderate or high on distress and 4% had the intention to leave the crisis line service within 1 year. Most work- and organization-related demands were positively associated with volunteers' distress and intention to leave the organization. Being older, being male and spending more hours per week volunteering were significantly, positively correlated with work-related demands. The total explained variance for distress was 16% and for intention to leave 13%.Conclusion:Although most crisis line volunteers experienced low impact from work- and organization-related demands, these demands were significantly related to experienced distress and the intention to leave crisis line service. For volunteers with moderate to high distress it can be useful to implement interventions aimed at increasing personal resources to help them deal with the challenges of the work at the crisis line.
Comparisons Between First Person Point-of-View 180° Video Virtual Reality Head-Mounted Display and 3D Video Computer Display in Teaching Undergraduate Neuroscience Students Stereotaxic Surgeries
Authors: Neuwirth Lorenz S. , Ros Maxime 
Published: July 2021

Introduction:Students interested in neuroscience surgical applications learn about stereotaxic surgery mostly through textbooks that introduce the concepts but lack sufficient details to provide students with applied learning skills related to biomedical research. The present study employed a novel pedagogical approach which used an immersive virtual reality (VR) alternative to teach students stereotaxic surgery procedures through the point of view (POV) of the neuroscientist conducting the research procedures.Methods:The study compared the 180° video virtual reality head-mounted display (180° video VR HMD) and the 3D video computer display groups to address the learning gaps created by textbooks that insufficiently teach stereotaxic surgery, by bringing students into the Revinax®Virtual Training Solutions educational instruction platform/technology. Following the VR experience, students were surveyed to determine their ratings of the learning content and comprehension of the material and how it compared to a traditional lecture, an online/hybrid lecture, and YouTube/other video content, as well as whether they would have interest in such a pedagogical tool.Results:The 180° video VR HMD and the 3D video computer display groups helped students attend to and learn the material equally, it improved their self-study, and they would recommend that their college/university invest in this type of pedagogy. Students reported that both interventions increased their rate of learning, their retention of the material, and its translatability. Students equally preferred both interventions over traditional lectures, online/hybrid courses, textbooks, and YouTube/other video content to learn stereotaxic surgery.Conclusion:Students preferred to learn in and achieve greater learning outcomes from both the 180° video VR HMD and the 3D video computer display over other pedagogical instructional formats and thought that it would be a more humane alternative to show how to conduct the stereotaxic surgical procedure without having to unnecessarily use/practice and/or demonstrate on an animal. Thus, this pedagogical approach facilitated their learning in a manner that was consistent with the 3-Rs in animal research and ethics. The 180° video VR HMD and the 3D video computer display can be a low-cost and effective pedagogical option for distance/remote learning content for students as we get through the COVID-19 pandemic or for future alternative online/hybrid classroom instruction to develop skills/reskill/upskill in relation to neuroscience techniques.
A Novel Allele Encoding 7-Hydroxymethyl Chlorophyll a Reductase Confers Bacterial Blight Resistance in Rice
Authors: Kampire Marie Gorette , Sanglou Ringki Kuinamei , Wang Huimei , Kazeem Bello Babatunde , Wu Jian-li , Zhang Xiaobo 
Published: July 2021

Rice spotted leaf mutants are helpful to investigate programmed cell death (PCD) and defense response pathways in plants. Using a map-based cloning strategy, we characterized novel rice spotted leaf mutation splHM143 that encodes a 7-hydroxymethyl chlorophyll a reductase (OsHCAR). The wild-type (WT) allele could rescue the mutant phenotype, as evidenced by complementation analysis. OsHCAR was constitutively expressed at all rice tissues tested and its expression products localized to chloroplasts. The mutant exhibited PCD and leaf senescence with increased H2O2 (hydrogen peroxide) accumulation, increased of ROS (reactive oxygen species) scavenging enzymes activities and TUNEL (terminal deoxyribonucleotidyl transferase-mediated dUTP nick-end labeling) -positive nuclei, upregulation of PCD related genes, decreased chlorophyll (Chl) contents, downregulation of photosynthesis-related genes, and upregulation of senescence-associated genes. Besides, the mutant exhibited enhanced bacterial blight resistance with significant upregulation of defense response genes. Knockout lines of OsHCAR exhibited spotted leaf phenotype, cell death, leaf senescence, and showed increased resistance to the bacterial pathogen Xanthomonas oryzae pv. oryzae (Xoo) coupled with upregulation of five pathogenesis-related marker genes. The overexpression of OsHCAR resulted in increased susceptibility to Xoo with decreased expression of pathogenesis-related marker genes. Altogether, our findings revealed that OsHCAR is involved in regulating cell death and defense response against bacterial blight pathogen in rice.
PENGARUH MENDENGARKAN AL-QUR’AN DAN MUSIK KLASIK TERHADAP PENURUNAN TEKANAN DARAH PADA MASYARAKAT RT 05 RW 12 KELURAHAN TANGKERANG SELATAN KOTA PEKANBARU TAHUN 2020
Authors: Priwahyuni Yuyun , Gloria Purba Christine Vita , Alamsyah Agus , Ikhtiaruddin Ikhtiaruddin 
Published: July 2021

Tekanan darah adalah suatu tekanan yang terdapat didalam pembuluh darah yang terjadi saat jantung memompakan darah keseluruh tubuh. Kenaikan pada arteri secara normal sampai dengan 120 mmHg disebut tekanan sistol yang terjadi saat jantung berkontraksi untuk memompakan darah pada saat relaksasi dimana ventrikel tekanan aorta cendrung akan menurun sampai dengan 80 mmHg, yang disebut tekanan diastole. Prevalensi hipertensi di Riau (29,2%) (Riskesdas, 2018). Lantunan Al-Qur’an mengandung unsur suara manusia, yang merupakan instrument penyembuhan yang menakjubkan dan alat yang paling mudah dijangkau. Mendengarkan musik juga dapat menstimulasi hipotalamus, yang merupakan pusat pengaturan berbagai mekanisme tubuh, sehingga akan mempengaruhi tekanan darah, nadi, respirasi, dan mood. Hasil Survei di RT 05 RW 12 Kelurahan Tangkerang Selatan Kota Pekanbaru terhadap 35 Masyarakat didapatkan hasil 20 (57%) yang memiliki tekanan darah diatas 120/80 mmHg. Penelitian ini bertujuan untuk mengetahui pengaruh terapi mendengarkan Al-Qur’an dan musik klasik terhadap penurunan tekanan darah pada Masyarakat RT 05 RW 12 Kelurahan Tangkerang Selatan Kota Pekanbaru Tahun 2020. Jenis penelitian analitik dengan desain quasi eksperiment. Populasi sebanyak 20 orang dengan tekanan darah diatas 120/80 mmHg, sampel adalah total populasi Pengolahan data secara komputerisasi. Analisis data yang digunakan adalah analisis univariat dan bivariat dengan uji paired t test. Terjadi penurunan tekanan darah pada kelompok mendengarkan Al-Qur’an dan kelompok mendengarkan musik klasik, perbandingan penurunan tekanan darah pada kelompok mendengarkan Al-Qur’an lebih besar yakni 8,7 dibandingkan dengan kelompok mendengarkan musik klasik yakni sebesar 1,7. nilai signifikansi (2-tailed) adalah 0,0001 sehingga hasil tes awal dan tes akhir mengalami perubahan yang signifikan (berarti). Diharapkan kepada Ketua RT dan perangkatnya dapat berkoordinasi dengan pihak puskesmas setempat untuk dapat melaksanakan kegiatan pemeriksaan tekanan darah secara berkala agar penyakit degeneratif seperti hipertensi dapat dikendalikan.
Kata Kunci : tekanan darah, murotal Al-Qur’an surat Ar-Rahman, musik klasik
Corporate Governance and Risk Management: A Study of Board Structure in Indonesian and Singapore Companies
Authors: Muhammad Muhammad , Narullia Dwi 
Published: July 2021

This study aims to determine the effect of the board structure on business risk management. One indicator that can show the implementation of risk management is risk disclosure by the company. This study uses a quantitative approach with the research population being companies in Indonesia and Singapore included in the ASEAN Stars 2015 – 2018. Furthermore, this study uses a regression analysis technique to examine the effect of the board structure on corporate risk management. The results of this study indicate that although the structure of the board of companies included in ASEAN STARS in Indonesia and Singapore has differences, the results of the analysis of the two are not much different. This study shows that an independent board of commissioners and the frequency of meetings have a significant effect on the company's risk management. Otherwise, the composition of the female board of commissioners is proven not to affect the risk management. Overall, the results also show an increase in corporate governance activities and an increase in risk management activities. The results of this study can be used as input for potential investors to evaluate quantitative information, and other qualitative information such as the role of the board of commissioners and risk disclosure can be useful in decision making.
<p>Penyisipan Kata Berbahasa Indonesia dalam Drama &ldquo;Pak Bhabin&rdquo; <em>(Indonesian Word Inserting in the Drama &ldquo;Pak Bhabin&rdquo;)</em></p>
Authors: Setyowati Herlina , Qurniawati Zuly , W. Dwi Anjani 
Published: July 2021

Fenomena kedwibahasaan dapat ditemukan dalam drama “Pak Bhabin” produksi Polisi Motret. Drama “Pak Bhabin” tersebut merupakan drama berbahasa Jawa, tetapi terkadang terdapat sisipan kata berbahasa Indonesia. Hal ini merupakan gejala campur kode. Tujuan penelitian ini untuk mengkaji wujud campur kode kata berbahasa Indonesia dalam drama “Pak Bhabin”. Teknik pengumpulan data menggunakan teknik simak dan catat. Adapun metode analisis data menggunakan metode agih dengan teknik lesap dan teknik ganti. Peneliti menyimak tayangan drama “Pak Bhabin” di kanal YouTube Polisi Motret yang tayang pada tahun 2019. Berdasarkan hasil penelitian, peneliti menemukan penyisipan kata berbahasa Indonesia dengan jenis 1) kata benda yang utuh, misalnya: jalan, pakaian, dan sangkar; serta penyisipan campuran, misalnya: uange, cita-citane, dan cobaane; 2) kata kerja yang utuh, misalnya: ulangi, mengkhianati, dan percaya; serta penyisipan campuran, misalnya: nglempar-lempar; 3) kata keadaan, antara lain: bawel, rajin, dan cengeng. Bilingual phenomenon can be found in the drama "Pak Bhabin" produced by the Motret Police. Pak Bhabin is a drama spoken in Javanese, but sometimes inserted by Indonesian words. This is a symptom of code mixing. The purpose of this research is to examine the code mixing used in Pak Bhabin drama. The data collection technique used was the observation and note-taking technique. The data analysis method used was the agih method with delesion techniques and substitution techniques. The researcher watched the "Pak Bhabin" program on the Motret Police YouTube channel which aired in 2019. Based on the results of the study, there are insertion of Indonesian words with type 1) complete nouns, for example: jalan, pakaian, and sangkar; as well as the insertion of mixtures, for example: uange, cita-citane, and cobaane; 2) complete verbs, for example: ulangi, mengkhianati, and percaya; as well as the insertion of mixtures, for example: nglempar-lempar; 3) adjective, among others: bawel, rajin, and cengeng.