bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salivary pH changes under the effect of stainless steel versus elastomeric ligatures in fixed orthodontic patients: a single-center, randomized controlled clinical trial
Authors: Al-Haifi Hend Abulkarem Abdullah , Ishaq Ramy Abdulrahman Ali , Al-Hammadi Maged Sultan Abdullah 
Published: October 2021

AbstractBackgroundFluctuations in pH of saliva during a prolonged treatment course influences the enamel demineralization progress, which is one of the complications of fixed orthodontic treatment. This randomized clinical trial aimed to evaluate and compare the short-term effects of stainless steel (SS) versus elastomeric (EM) ligatures on salivary pH in patients scheduled for fixed orthodontic treatment.MethodsSeventy participants were enrolled in the study (54 female, 16 male) aged 19–36 years who met specific inclusion criteria. They were randomly selected and allocated into two equal groups through computer-generated randomization. All patients received fixed orthodontic treatment using conventional orthodontic brackets. Two commonly used archwire ligature methods were used: SS and EMs. An unstimulated (resting) salivary sample was collected before tying of the ligatures at T0 (baseline), 2 weeks, 6 (weeks), and 12 (weeks). Salivary pH was measured using a digital pH meter. The level of significance was set at p value < 0.05.ResultsThe salivary pH level was stable between T0 and T1 (6.72 ± 0.14), then significantly and progressively increased from T1 to T2 (6.78 ± 0.13) and from T2 to T3 (6.81 ± 0.14) with (p < 0.05) in the SS group. In the EM group, the salivary pH level was significantly decreased in all follow-up periods; T0 (6.77 ± 0.16), T1 (6.72 ± 0.14), T2 (6.67 ± 0.13) and T3 (6.64 ± 0.13).ConclusionThe EM ligatures showed a significant decrease in salivary pH to an unfavorable level, which increased the risk of enamel demineralization. Therefore, EMs as ligature material is preferably should not be recommended in patients with high caries index or inadequate oral hygiene.Trial registrationANZCTR.org. (ACTRN12618001647224)http://www.anzctr.org.au/ACTRN12618001647224.aspx. Registration Date: 5/10/2018, “Retrospectively registered”.
Applying artificial neural network for early detection of sepsis with intentionally preserved highly missing real-world data for simulating clinical situation
Authors: Kuo Yao-Yi , Huang Shu-Tien , Chiu Hung-Wen 
Published: October 2021

Abstract
Purpose
Some predictive systems using machine learning models have been developed to predict sepsis; however, they were mostly built with a low percent of missing values, which does not correspond with the actual clinical situation. In this study, we developed a machine learning model with a high rate of missing and erroneous data to enable prediction under missing, noisy, and erroneous inputs, as in the actual clinical situation.

Materials and methods
The proposed artificial neural network model was implemented using the MATLAB ANN toolbox, based on stochastic gradient descent. The dataset was collected over the past decade with approval from the appropriate institutional review boards, and the sepsis status was identified and labeled using Sepsis-3 clinical criteria. The imputation method was built by last observation carried forward and mean value, aimed to simulate clinical situation.

Results
The mean area under the receiver operating characteristic (ROC) curve (AUC) of classifying sepsis and nonsepsis patients was 0.82 and 0.786 at 0 h and 40 h prior to onset, respectively. The highest model performance was found for one-hourly data, demonstrating that our ANN model can perform adequately with limited hourly data provided.

Conclusions
Our model has the moderate ability to predict sepsis up to 40 h in advance under simulated clinical situation with real-world data.
The IDeaS initiative: pilot study to assess the impact of rare diseases on patients and healthcare systems
Authors: Tisdale Ainslie , Cutillo Christine M. , Nathan Ramaa , Russo Pierantonio , Laraway Bryan , Haendel Melissa , Nowak Douglas , Hasche Cindy , Chan Chun-Hung , Griese Emily , Dawkins Hugh , Shukla Oodaye , Pearce David A. , Rutter Joni L. , Pariser Anne R. 
Published: October 2021

Abstract
Background
Rare diseases (RD) are a diverse collection of more than 7–10,000 different disorders, most of which affect a small number of people per disease. Because of their rarity and fragmentation of patients across thousands of different disorders, the medical needs of RD patients are not well recognized or quantified in healthcare systems (HCS).

Methodology
We performed a pilot IDeaS study, where we attempted to quantify the number of RD patients and the direct medical costs of 14 representative RD within 4 different HCS databases and performed a preliminary analysis of the diagnostic journey for selected RD patients.

Results
The overall findings were notable for: (1) RD patients are difficult to quantify in HCS using ICD coding search criteria, which likely results in under-counting and under-estimation of their true impact to HCS; (2) per patient direct medical costs of RD are high, estimated to be around three–fivefold higher than age-matched controls; and (3) preliminary evidence shows that diagnostic journeys are likely prolonged in many patients, and may result in progressive, irreversible, and costly complications of their disease

Conclusions
The results of this small pilot suggest that RD have high medical burdens to patients and HCS, and collectively represent a major impact to the public health. Machine-learning strategies applied to HCS databases and medical records using sentinel disease and patient characteristics may hold promise for faster and more accurate diagnosis for many RD patients and should be explored to help address the high unmet medical needs of RD patients.
Upregulation of cathepsin L gene under mild cold conditions in young Japanese male adults
Authors: Yasukochi Yoshiki , Shin Sora , Wakabayashi Hitoshi , Maeda Takafumi 
Published: October 2021

AbstractBackgroundPhysiological thermoregulatory systems in humans have been a key factor for adaptation to local environments after their exodus from Africa, particularly, to cold environments outside Africa. Recent studies using high-throughput sequencing have identified various genes responsible for cold adaptation. However, the molecular mechanisms underlying initial thermoregulation in response to acute cold exposure remain unclear. Therefore, we investigated transcriptional profiles of six young Japanese male adults exposed to acute cold stress.MethodsIn a climatic chamber, the air temperature was maintained at 28°C for 65 min and was then gradually decreased to 19°C for 70 min. Saliva samples were obtained from the subjects at 28°C before and after 19°C cold exposure and were used for RNA sequencing.ResultsIn the cold exposure experiment, expression levels of 14 genes were significantly changed [false discovery rate (FDR) < 0.05] although the degree of transcriptional changes was not high due to experimental conditions or blunted transcriptional reaction in saliva to cold stress. As a result, differential gene expression analyses detected the cathepsin L (CTSL) gene to be significantly upregulated, with FDR < 0.05 and log2fold change value > 1; thus, this gene was identified as a differentially expressed gene. Given that the cathepsin L protein is related to invasion of the novel coronavirus (SARS-CoV-2), mild cold stress might alter the susceptibility to coronavirus disease-19 in humans. The gene ontology enrichment analysis for 14 genes with FDR < 0.05 suggested that immune-related molecules could be activated by mild cold stress.ConclusionsThe results obtained from this study indicate thatCTSLexpression levels can be altered by acute mild cold stress.
Depth- and temperature-specific fatty acid adaptations in ctenophores from extreme habitats
Authors: Winnikoff Jacob R. , Haddock Steven H. D. , Budin Itay 
Published: October 2021

ABSTRACT
Animals are known to regulate the composition of their cell membranes to maintain key biophysical properties in response to changes in temperature. For deep-sea marine organisms, high hydrostatic pressure represents an additional, yet much more poorly understood, perturbant of cell membrane structure. Previous studies in fish and marine microbes have reported correlations with temperature and depth of membrane-fluidizing lipid components, such as polyunsaturated fatty acids. Because little has been done to isolate the separate effects of temperature and pressure on the lipid pool, it is still not understood whether these two environmental factors elicit independent or overlapping biochemical adaptive responses. Here, we use the taxonomic and habitat diversity of the phylum Ctenophora to test whether distinct low-temperature and high-pressure signatures can be detected in fatty acid profiles. We measured the fatty acid composition of 105 individual ctenophores, representing 21 species, from deep and shallow Arctic, temperate, and tropical sampling locales (sea surface temperature, −2° to 28°C). In tropical and temperate regions, remotely operated submersibles (ROVs) enabled sampling down to 4000 m. We found that among specimens with body temperatures 7.5°C or colder, depth predicted fatty acid unsaturation levels. In contrast, in the upper 200 m of the water column, temperature predicted fatty acid chain lengths. Taken together, our findings suggest that lipid metabolism may be specialized with respect to multiple physical variables in diverse marine environments. Largely distinct modes of adaptation to depth and cold imply that polar marine invertebrates may not find a ready refugium from climate change in the deep.
Effects of a snack on performance and errors during a simulated 16-h night shift: A randomized, crossover-controlled, pilot study
Authors: Oriyama Sanae , Yamashita Kotomi 
Published: October 2021

BackgroundNight shift workers might not eat due to their busy schedules during the night shift. However, food may not only satisfy hunger, but also affect performance and errors. The aim of this study was to clarify the effect of a snack on performance and errors during 2-day, 16-h, simulated night shifts.MethodsA randomized, repeated-measure, crossover study was performed to investigate subjective and cognitive performance in 15 healthy female adults (mean age, 21.7 years) after they consumed a snack (352 kcal) during a simulated night shift (16:00 to 09:00) from October to November 2018. The participants were kept awake from waking up in the morning to the next day at 09:00. Subjects were tested for performance on the Uchida-Kraepelin test, as well as for subjective feeling, body temperature, psychomotor vigilance test, and heart rate variability, before and after they consumed the snack. One day before the experiment, all participants wore an actigraphy monitoring device to determine their sleep state.ResultsThere was no difference between having (Snack condition) and not having (Skipping condition) the snack in sleep states the day before the experiment. On the day of the experiment, between 16:00 and 09:00, subjective sleepiness, fatigue, and body temperature were not different between the two conditions. Subjects maintained performance on the Uchida-Kraepelin test and showed a significant improvement in false starts on the psychomotor vigilance test, the primary outcome measure, in the Snack condition compared with the Skipping condition. The Snack condition was also associated with decreased high-frequency power, a decreased low-frequency power/high-frequency power ratio, and increased heart rate in the vagally mediated heart rate variability indices, which may reflect a higher ability to modulate cognitive and behavioral processes.ConclusionsThese results suggest that providing a snack to shift workers during night shifts might improve work safety and efficiency.
Refractive results with SMILE using lower energy settings in the United States
Authors: Liu Erica T. , Sella Ruti , Goernert Phillip , Kim Kevin , Chen Henry , Lin Robert T. 
Published: October 2021

Purpose
To report the visual and refractive results of small incision lenticule extraction (SMILE) with low energy settings in the United States (US) and to evaluate outcomes for low astigmatism treatment.

Setting
Private clinical practice.

Design
Retrospective cohort study.

Methods
This study retrospectively reviewed 462 consecutive eyes that underwent SMILE with lower energy settings. Inclusion criteria included all patients between the ages of 19–39 with myopic astigmatism up to -11.25 diopters (D) spherical equivalent (sphere up to -10.00 D, astigmatism up to -3.00 D), and corrected distance visual acuity of at least 20/25. Eyes with low astigmatism (0.25 D-0.50 D) were also included. Outcome analysis was performed according to the Standard Graphs for Reporting Refractive Surgery at postoperative month (POM) 1, and POM 3–6 when data were available.

Results
The mean preoperative spherical equivalent treated was -4.96 ± 2.07; at POM 1, 92% of eyes achieved uncorrected visual acuity (UCVA) of 20/20 or better and maintained visual stability throughout the remainder of the study. At last visit, 431 eyes (93%) achieved UCVA of 20/20 or better, and 461 eyes (99.8%) were 20/25 or better. Ninety-seven (21%) eyes gained at least 1 Snellen line of corrected distance visual acuity and no eyes lost 2 or more lines. Almost all eyes (n = 453, 98%) were within 0.5D of target; 85% of eyes with low astigmatism had ≤0.25 D at last visit compared to 80% of eyes with moderate astigmatism.

Conclusions
SMILE with U.S.-approved low energy settings is safe, predictable, and efficacious and provides patients with a fast visual recovery.
Acting for Real: Drama Therapy Process, Technique, and Performance, Renée Emunah (2020)
Authors: Kidder Bobbi 
Published: October 2021

Review of: Acting for Real: Drama Therapy Process, Technique, and Performance, Renée Emunah (2020)
2nd ed., New York and Oxon: Routledge, 382 pp.,
ISBN 978-1-13884-964-8, h/bk, $120; ISBN 978-1-13884-965-5, p/bk, $35.96; ISBN: 978-1-31572-540-6, e/bk, $35.96
Database isolation by scheduling
Authors: Gaffney Kevin P. , Claus Robert , Patel Jignesh M. 
Published: October 2021

Transaction isolation is conventionally achieved by restricting access to the physical items in a database. To maximize performance, isolation functionality is often packaged with recovery, I/O, and data access methods in a monolithic transactional storage manager. While this design has historically afforded high performance in online transaction processing systems, industry trends indicate a growing need for a new approach in which intertwined components of the transactional storage manager are disaggregated into modular services. This paper presents a new method to modularize the isolation component. Our work builds on predicate locking, an isolation mechanism that enables this modularization by locking logical rather than physical items in a database. Predicate locking is rarely used as the core isolation mechanism because of its high theoretical complexity and perceived overhead. However, we show that this overhead can be substantially reduced in practice by optimizing for common predicate structures.
We present DIBS, a transaction scheduler that employs our predicate locking optimizations to guarantee isolation as a modular service. We evaluate the performance of DIBS as the sole isolation mechanism in a data processing system. In this setting, DIBS scales up to 10.5 million transactions per second on a TATP workload. We also explore how DIBS can be applied to existing database systems to increase transaction throughput. DIBS reduces per-transaction file system writes by 90% on TATP in SQLite, resulting in a 3X improvement in throughput. Finally, DIBS reduces row contention on YCSB in MySQL, providing serializable isolation with a 1.4X improvement in throughput.
Comparison of the QuikRead go® point-of-care faecal immunochemical test for haemoglobin with the FOB Gold Wide® laboratory analyser to diagnose colorectal cancer in symptomatic patients
Authors: Maclean William , Zahoor Zahida , O’Driscoll Shane , Piggott Carolyn , Whyte Martin B. , Rockall Timothy , Jourdan Iain , Benton Sally C. 
Published: October 2021

Abstract

Objectives
Faecal immunochemical testing for haemoglobin (FIT) is used to triage patients for colonic investigations. Point-of-care (POC) FIT devices on the market have limited data for their diagnostic accuracy for colorectal cancer (CRC). Here, a POC FIT device is compared with a laboratory-based FIT system using patient collected samples from the urgent referral pathway for suspected CRC.

Methods
A prospective, observational cohort study. Patients collected two samples from the same stool. These were measured by POC QuikRead go® (Aidian Oy, Espoo, Finland) and laboratory-based FOB Gold Wide® (Sentinel Diagnostics, Italy). Faecal haemoglobin <10 μg haemoglobin/g of faeces was considered as negative. At this threshold, comparisons between the two systems were made by calculating percentage agreement and Cohen’s kappa coefficient. Proportion of negative results were compared with Chi squared testing. Sensitivities for CRC were calculated.

Results
A total of 629 included patients provided paired samples for FIT to compare the QuikRead go® and FOB Gold Wide®. The agreement around the negative threshold was 83.0% and Cohen’s kappa coefficient was 0.54. The QuikRead go® reported 440/629 (70.0% of samples) as negative compared to 523/629 (83.1%) for the FOB Gold Wide®, this difference was significant (p-value<0.001). Sensitivities for CRC detection by the QuikRead go® and FOB Gold Wide® were 92.9% (95% confidence interval (CI): 68.5–98.7%) and 100% (CI: 78.5–100%) respectively.

Conclusions
Both systems were accurate in their ability to detect CRC. Whilst good agreement around the negative threshold was identified, more patients would be triaged to further colonic investigation if using the QuikRead go®.
The discursive construction of accountability for communicative action to citizens: A contrastive analysis across Israeli and British media discourse
Authors: Weizman Elda , Fetzer Anita 
Published: October 2021

Abstract
This paper sets up to show how accountability for communicative action is constructed in online journalism as an object of talk, comparing British English and Israeli Hebrew discourse communities. The analysis utilizes a discourse-pragmatic frame of reference supplemented by cognitive semantics and corpus-assisted tools. The discussion draws on data collected from the websites of The Guardian and The Daily Telegraph, Ha’aretz and Ynet. Focusing on self- and other-positioning of commenters and columnists as citizens, we explore how the accountability of the elite for communicative action and the accountability of their actions to citizens are discursively constructed by ordinary persons (in their role as commenters) and by non-ordinary persons (in their role as columnists, including journalists, experts and authors). The analysis indicates conceptual similarities coupled with discursive differences between the discourse communities under study.
Arq Ajīb – a wonder Unani formulation for inhibiting SARS-CoV-2 spike glycoprotein and main protease – an in silico approach
Authors: Ahmed N. Zaheer , John Davis G. Dicky , Khan Asim Ali , Prabhakar Lavanya , Ram Paratap Meena , Afnaan Zeba , Devi Sri Meera , Anwar Noman 
Published: October 2021

Abstract

Objectives
The current pandemic caused by Severe Acute Respiratory Syndrome Corona-Virus 2 (SARS-CoV-2) has become a global health menace with significant morbidity and mortality besides huge socioeconomic implications. Despite the approval of few vaccines for the prevention of the disease, the discovery of safe and effective countermeasures especially from natural sources is of paramount importance, as the number of cases continues escalating. Arq Ajīb has long been used for various diseases and its ingredients have been reported for antiviral, antimicrobial, antipyretic, anti-inflammatory, antioxidant activities. The present study investigates the inhibitory effect of phytocompound of Arq Ajīb on potential drug targets of SARS-CoV-2.

Methods
The structures of phytocompounds present in Arq Ajīb were retrieved from PubChem database and some were illustrated using Marvin Sketch. SARS-CoV-2 S glycoprotein (PDB ID: 6LZG) and 3CLpro (PDB ID: 7BQY) were selected as the target protein. Dock Prep module in UCSF Chimera software was used for receptor structure processing. AutoDock Vina was used to calculate the binding affinities between the protein and ligands and to predict most promising compounds with best scores.

Results
Molecular docking results predicted that the phytocompounds of Arq Ajīb had good binding affinity and interaction with S glycoprotein and 3CLpro. Quercetin and Isorhoifolin from Mentha arvensis were identified as promising candidates with the potential to interact with 3CLpro and spike glycoprotein and inhibit the viral replication and its entry into the host.

Conclusions
Arq Ajīb may prove valuable for developing novel therapeutic candidate for COVID-19; however, it has to be substantiated further with in-vitro and in-vivo studies.
Pediatric adrenocortical tumors cohort characteristics and long-term follow-up at a single Argentinian tertiary center
Authors: Mattone María Celeste , Gil Silvia , Costanzo Mariana , Galluzzo Mutti María Laura , Casanovas Alejandra , Zaidman Verónica , Lazzati Juan Manuel , Ciaccio Marta , Belgorosky Alicia , Guercio Gabriela 
Published: October 2021

Abstract

Pediatric adrenocortical tumors are rare and heterogeneous endocrine malignancies.

Objectives
To report clinical, biochemical, and histological features, staging, and therapeutic interventions in a cohort of 28 patients treated at a single tertiary center.

Methods
A retrospective review of medical records of children with PACT (diagnosed before <18 years of age) followed between 1987–2018 at Hospital de Pediatría Garrahan, Buenos Aires, Argentina.

Results
Mean age at diagnosis was 4.6 years (range, 0.3–17.3 years) and median follow-up was 4.17 years (range, 0–12 years). Female to male ratio was 2.5:1. Signs and symptoms that prompted medical intervention were hormonal overproduction (57%), abdominal complaints (36%), and hypertensive encephalopathy (7%). In patients with clinically virilizing tumors (n=16) mean height standard deviation score (SDS) and bone age advance were significantly higher while body mass index (BMI) SDS was significantly lower than in those with clinical Cushing’s (n=10) (p<0.05). Serum dehydroepiandrosterone sulfate (DHEAS) levels were significantly higher in stage IV than in stage I (p=0.03). Total adrenalectomy was performed in 26 patients. Eight patients (stage III-IV) received adjuvant chemotherapy. Five-year overall and disease-free survival were 100% for ST I-II, and 51% (95% CI 21–82) and 33% (95% CI 1.2–65) for ST III-IV, respectively (p=0.002). No statistical difference was found when comparing 2-year parameters with and without adjuvant chemotherapy.

Conclusions
Height SDS and BMI SDS seem to mirror hormonal secretion in pediatric adrenocortical tumors. Higher DHEAS levels were found in patients with more advanced disease. Further large-scale studies are needed to validate a possible role for DHEAS as a biochemical marker of tumor stage and to draw robust conclusions on the use of adjuvant chemotherapy.