bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Minds: Modes of Modeling and Simulation in Artificial Intelligence
Authors: Greif Hajo 
Published: September 2021

AbstractThe aim of this paper is to grasp the relevant distinctions between various ways in which models and simulations in Artificial Intelligence (AI) relate to cognitive phenomena. In order to get a systematic picture, a taxonomy is developed that is based on the coordinates of formal versus material analogies and theory-guided versus pre-theoretic models in science. These distinctions have parallels in the computational versus mimetic aspects and in analytic versus exploratory types of computer simulation. The proposed taxonomy cuts across the traditional dichotomies between symbolic and embodied AI, general intelligence and symbol and intelligence and cognitive simulation and human/non-human-like AI.According to the taxonomy proposed here, one can distinguish between four distinct general approaches that figured prominently in early and classical AI, and that have partly developed into distinct research programs: first, phenomenal simulations (e.g., Turing’s “imitation game”); second, simulations that explore general-level formal isomorphisms in pursuit of a general theory of intelligence (e.g., logic-based AI); third, simulations as exploratory material models that serve to develop theoretical accounts of cognitive processes (e.g., Marr’s stages of visual processing and classical connectionism); and fourth, simulations as strictly formal models of a theory of computation that postulates cognitive processes to be isomorphic with computational processes (strong symbolic AI).In continuation of pragmatic views of the modes of modeling and simulating world affairs, this taxonomy of approaches to modeling in AI helps to elucidate how available computational concepts and simulational resources contribute to the modes of representation and theory development in AI research—and what made that research program uniquely dependent on them.
Two Exploratory Uses for General Circulation Models in Climate Science
Authors: Wilson Joseph 
Published: September 2021

AbstractIn this paper I present two ways in which climate modelers use general circulation models for exploratory purposes. The complexity of Earth’s climate system makes it difficult to predict precisely how lower-order climate dynamics will interact over time to drive higher-order dynamics. The same issues arise for complex models built to simulate climate behavior like the Community Earth Systems Model (CESM). I argue that as a result of system complexity, climate modelers use general circulation models to perform model dynamic exploration (MDE) and climate dynamic exploration (CDE). MDE and CDE help climate modelers to better understand the dynamic structure of the general circulation model system and the actual climate system, respectively.
Effects of conspecific density on tadpole risk assessment and defensive behaviour
Authors: Gazzola Andrea , Balestrieri Alessandro , Brazzale Giulia , Pellitteri-Rosa Daniele 
Published: September 2021

Abstract
Prey species assess predation risk by using either direct and indirect cues and both may contribute to a proper evaluation of the actual risk. As postulated by the risk assessment hypothesis, conspecific density may also provide useful information for tuning defensive responses. We tested this hypothesis using a combination of five density levels (1, 2, 4, 8 and 16 individuals) of Italian agile frog Rana latastei tadpoles and three treatments (control, predatory cues of common backswimmer Notonecta glauca and a waterjet of tap water as mechanical disturbance). Tadpole activity decreased in response to all stimuli but, as expected, backswimmer cues induced a stronger and lasting response. However, tadpole activity level did not vary with group size, thus providing no support for the risk assessment hypothesis and confirming that conspecific density might have less consistent effects on short-term behavioural responses than morphological and life history traits.
Changes in Tornado Climatology Accompanying the Enhanced Fujita Scale
Authors: Edwards Roger , Brooks Harold E. , Cohn Hannah 
Published: September 2021

AbstractUnited States tornado records form the basis for a variety of meteorological, climatological and disaster-risk analyses, but how reliable are they in light of changing standards for rating, as with the 2007 transition of Fujita (F) to Enhanced Fujita (EF) damage scales? To what extent are recorded tornado metrics subject to such influences that may be nonmeteorological in nature? While addressing these questions with utmost thoroughness is too large of a task for any one study, and may not be possible given the many variables and uncertainties involved, some variables that are recorded in large samples are ripe for new examination. We assess basic tornado-path characteristics—damage rating, length, width, and occurrence time, as well as some combined and derived measures—for a 24-yr period of constant path-width recording standard that also coincides with National Weather Service modernization and the WSR-88D deployment era. The middle of that period (in both time and approximate tornado counts) crosses the official switch from F to EF. At least minor shifts in all assessed path variables are associated directly with that change, contrary to the intent of EF implementation. Major and essentially stepwise expansion of tornadic path widths occurred immediately upon EF usage, and widths have expanded still further within the EF era. We also document lesser increases in path lengths, and in tornadoes rated at least EF1 compared to EF0. These apparently secular changes in the tornado data can impact research dependent on bulk tornado-path characteristics and damage-assessment results.
Numerical impacts on tracer transport: Diagnosing the influence of dynamical core formulation and resolution on stratospheric transport
Authors: Gupta Aman , Gerber Edwin P. , Plumb R. Alan , Lauritzen Peter H. 
Published: September 2021

AbstractAccurate representation of stratospheric trace gas transport is important for ozone modeling and climate projection. Intermodel spread can arise from differences in the representation of transport by the diabatic (overturning) circulation vs. comparatively faster adiabatic mixing by breaking waves, or through numerical errors, primarily diffusion. This study investigates the impact of these processes on transport using an idealised tracer, the age-of-air. Transport is assessed in two state-of-the-art dynamical cores based on fundamentally different numerical formulations: finite volume and spectral element. Integrating the models in free-running and nudged tropical wind configurations reveals the crucial impact of tropical dynamics on stratospheric transport. Using age-budget theory, vertical and horizontal gradients of age allow comparison of the roles of the diabatic circulation, adiabatic mixing, and the numerical diffusive flux. Their respective contribution is quantified by connecting the full 3-d model to the tropical leaky pipe framework of Neu and Plumb (1999). Transport by the two cores varies significantly in the free-running integrations, with the age in the middle stratosphere differing by about 2 years primarily due to differences in adiabatic mixing. When winds in the tropics are constrained, the difference in age drops to about 0.5 years; in this configuration, more than half the difference is due to the representation of the diabatic circulation. Numerical diffusion is very sensitive to the resolution of the core, but does not play a significant role in differences between the cores when they are run at comparable resolution. It is concluded that fundamental differences rooted in dynamical core formulation can account for a substantial fraction of transport bias between climate models.
Assessment of the possibility of surgical masks re-use after a sterilization process in the pandemic condition of COVID-19
Authors: Zimniewska Malgorzata , Witmanowski Henryk , Kicinska-Jakubowska Anna , Jundzill Arkadiusz , Kwiatkowska Edyta , Romanowska Barbara , Malinowski Lukasz B 
Published: September 2021

The aim of this study was to explore the possibility to re-use disposable masks in order to prevent excessive waste generation during the pandemic period. The COVID-19 pandemic has caused rapidly increasing waste production resulting from the necessity of common usage of disposable personal protective equipment. This research covers the evaluation of the structure of surgical masks subjected to a threefold steam, gas or plasma sterilization process in order to verify the possibility of their re-use. The results of the study showed that gas sterilization even after three cycles did not cause significant changes in mask structure or air permeability. Hydrogen peroxide plasma sterilization caused significant changes in the structure of layer A after the third cycle of sterilization; nonetheless, it did not influence the air permeability of the mask. A significant reduction in the cover ratio of layers composing surgical masks causes an increase of air permeability in the case of steam sterilization, leading to a reduction of the mechanical ability to prevent the penetration of microorganisms. The reduction in cover ratio limits the filtration efficiency. Surgical masks subjected to threefold gas sterilization can be recommended for re-use. This allows one to use the mask thrice, ensuring safety for users and limiting the mask-waste production to one-third of the volume compared with when the mask is used once. The volume of mask-waste can be reduced with the application of the sterilization process for used masks during the pandemic period. Currently, it is not possible to sterilize all one-use masks, but implementation of this method in hospitals and medical centers is a step in the pro-environmental direction.
Indications of Superselective Neck Dissection in Patients With Lateral Node Metastasis of Papillary Thyroid Carcinoma
Authors: Song Yuntao , Xu Guohui , Wang Tianxiao , Zhang Yabing , Zhang Bin 
Published: September 2021

ObjectiveThe extent of neck dissection in papillary thyroid carcinoma (PTC) patients with lateral neck metastasis is controversial. This work aims to screen the patients suitable for superselective neck dissections including only levels III‐IV.Study DesignProspective observational cohort study.SettingThe study was conducted in a high‐volume tertiary care setting.MethodsA total of 134 consecutive previously untreated PTC patients with lateral neck metastases and subjected to 154 therapeutic lateral neck dissections (including levels II, III, IV, and VB) between June 2018 and March 2021 were enrolled. Fine‐needle aspiration was performed preoperatively at each suspicious neck level. Clinical predictors were analyzed for occult lymph node metastases at levels II and VB.ResultsAs a result, 44.8% and 5.8% of neck specimens exhibited metastatic lymph nodes at levels II and VB. In addition, univariate and multivariate analyses showed that the primary tumor in the ipsilateral thyroid upper lobe (P =. 016, odds ratio = 3.528) and clinically multiple metastatic lymph nodes in level III‐IV (P =. 005, odds ratio = 6.414) were independent predictive factors for occult level II metastases. All 3 (1.9%) occult metastases at level VB were found in necks with preoperative multiple lymph node metastases.ConclusionsA superselective lateral neck dissection including levels III to IV may be considered in patients with PTC when the preoperative evaluation identifies a single lymph node metastasis located at levels III to IV and the primary tumor is not in the upper lobe of the ipsilateral thyroid.
Reflecting on the COVID‐19 Surgical Literature Surge: A Scoping Review of Pandemic Otolaryngology Publications
Authors: von Sneidern Manuela , Lehmann Ashton E. , Jafari Aria , Vlasakov Iliyan K. , Shen Sarek A. , Goss Deborah , Bleier Benjamin S. 
Published: September 2021

ObjectiveTo assess the high‐volume 2020 COVID‐19‐related surgical literature, with special attention to otolaryngology articles in regard to content, level of evidence, citations, and public attention.Study DesignA scoping literature review was performed with PubMed and Web of Science, including articles pertaining to COVID‐19 and surgical specialties (March 20–May 19, 2020) or otolaryngologic subspecialties (March 20–December 31, 2020).SettingScoping literature review.MethodsOtolaryngology‐specific COVID‐19‐related articles were reviewed for publication date, county of origin, subspecialty, content, level of evidence, and Altmetric Attention Score (a weighted approximation of online attention received). Data were analyzed with Pearson correlation coefficients, analysis of variance, independent t tests, and univariable and logistic regressions.ResultsThis review included 773 early COVID‐19 surgical articles and 907 otolaryngology‐specific COVID‐19‐related articles from 2020. Otolaryngology was the most represented surgical specialty within the early COVID‐19‐related surgical literature (30.4%). The otolaryngology‐specific COVID‐19 surgical literature responsively reflects the unique concerns within each otolaryngologic subspecialty. Although this literature was largely based on expert opinion (64.5%), articles with stronger levels of evidence received significantly more citations (on Web of Science and Google Scholar, P <. 001 for both) and public attention (according to Altmetric Attention Scores, P <. 001).ConclusionDespite concerns of a surge in underrefereed publications during the COVID‐19 pandemic, our review of the surgical literature offers some degree of reassurance. Specifically, the COVID‐19 otolaryngology literature responsively reflects the unique concerns and needs of the field, and more scholarly citations and greater online attention have been given to articles offering stronger levels of scientific evidence.
Diagnostic performance of mammography and magnetic resonance imaging for evaluating mammographically visible breast masses
Authors: Zhu Xueli , Cao Yi , Li Ruidie , Zhu Mingxia , Chen Xin 
Published: September 2021

Objective We compared the diagnostic values of mammography and magnetic resonance imaging (MRI) for evaluating breast masses. Methods We retrospectively analyzed mammography, MRI, and histopathological data for 377 patients with breast masses on mammography, including 73 benign and 304 malignant masses. Results The sensitivities and negative predictive values (NPVs) were significantly higher for MRI compared with mammography for detecting breast cancer (98.4% vs. 89.8% and 87.8% vs. 46.6%, respectively). The specificity and positive predictive values (PPV) were similar for both techniques. Compared with mammography alone, mammography plus MRI improved the specificity (67.1% vs. 37.0%) and PPV (91.8% vs. 85.6%), but there was no significant difference in sensitivity or NPV. Compared with MRI alone, the combination significantly improved the specificity (67.1% vs. 49.3%), but the sensitivity (88.5% vs. 98.4%) and NPV (58.3% vs. 87.8%) were reduced, and the PPV was similar in both groups. There was no significant difference between mammography and MRI in terms of sensitivity or specificity among 81 patients with breast masses with calcification. Conclusion Breast MRI improved the sensitivity and NPV for breast cancer detection. Combining MRI and mammography improved the specificity and PPV, but MRI offered no advantage in patients with breast masses with calcification.
The Mark Sheldon Remote Mental Health Team: an evaluation of patient demographics, diagnoses and clinical management in very remote Central Australia
Authors: Brightman Louise , O’Neill Samantha , Gorey Phyllis , Mitchell David , Tabart Marcus 
Published: September 2021

Objective: The Mark Sheldon Remote Mental Health Team provides psychiatric services to 29 communities in very remote Central Australia. This study evaluated Mark Sheldon Remote Mental Health Team patient demographics, diagnoses and clinical management. Methods: A retrospective cross-sectional review was performed for January 2020. Variables included age, sex, Indigenous status, diagnosis, legal status, medication class and route of administration. Results: A total of 180 patients were identified (85.6% Indigenous, 53.3% male). Schizophrenia and delusional disorders were most common (41.1%). A small proportion of patients (2.8%) were involuntary. Psychotropic medication was commonly prescribed (77.4%) with a low threshold for anti-psychotic depot use (51.5%). Oral medication rates varied according to class. Conclusions: This study provided insights into the demographic and clinical profile of a unique population. The findings will help to optimise patient management in very remote Central Australia and serve as a foundation for similar evaluations and comparisons with other remote psychiatric services.
Social media and orthodontics: Are our patients scrolling?
Authors: Siddiqui Nausheen , Chia Matthew , Sharif Mohammad Owaise 
Published: September 2021

Objective: To assess patients’ awareness of the availability of information related to orthodontics on social media, and to explore patients’ willingness to engage with social media to aid with orthodontic treatment. Design: Prospective cross-sectional survey. Setting: This survey was conducted at Croydon University Hospital orthodontic department. Participants: A total of 125 orthodontic patients, both new and in treatment. There were no exclusion criteria. Methods: All participants completed a questionnaire designed to explore their awareness, access to and utilisation of social media as well as their willingness to engage with social media to support orthodontic treatment. There were no age restrictions or exclusion criteria. Results: Of the patients, 99% had access to social media. Of these patients, 64% were aware that social media platforms were available to help with orthodontic treatment, 30% had utilised social media related to orthodontics, with the most popular platforms being Instagram (n = 17) and Snapchat (n = 12). Of the patients, 73% stated that they would be willing to use social media in the future to support orthodontic treatment. Conclusion: Social media can be engaging, accessible and versatile, and has been shown to be effective at improving patients’ knowledge regarding orthodontic treatment. As such, it may be used as a valuable tool for information provision to engage orthodontic patients. Awareness of the availability of orthodontics content on social media is increasing; however, only one-third of participants had previously used it to aid with orthodontic treatment. Given the availability of information on social media targeted at orthodontic patients there is a need to assess the quality of this information and if appropriate navigate patients towards high-quality, effective resources.
Development of the Subjective Cognitive Decline Scale for Mandarin-Speaking Population
Authors: Tsai Hsing-Fang , Wu Chi-Hsun , Hsu Chih-Cheng , Liu Chien-Liang , Hsu Yen-Hsuan 
Published: September 2021

Subjective cognitive decline (SCD) has been considered a high-risk group preceding mild cognitive impairment (MCI). However, methods to quantify and track the complaints have not been well-established. The present study aimed to develop a questionnaire tailored for Mandarin-speaking individuals with SCD. A total of 175 adults aged above 55 years completed a comprehensive set of items evaluating cognitive problems and neuropsychological examinations. After item reduction, internal consistency, construct, and concurrent validity were examined. The 14-item Subjective Cognitive Decline Scale (SCDS) has acceptable internal consistency (Cronbach’s α = .93) and construct validity with a three-factor structure. Individuals with SCD and MCI scored higher than the control group. The SCDS demonstrated significant but small correlations with multiple cognitive tests and emotional variables. The SCDS provides an alternative approach to measure cognitive complaints, while an influence of emotional status shall be taken into consideration when interpreting the results.
Transapical Antegrade Ascending Aorta Stent-Grafting: Going Through the Front Door
Authors: D’Onofrio Augusto , Cibin Giorgia , Antonello Michele , Caraffa Raphael , Grego Franco , Gerosa Gino 
Published: September 2021

Objective Ascending aorta stent-grafting (AASG) is a new option that has shown initial promising results. In selected cases, when neither conventional surgery nor transfemoral retrograde approach are feasible, antegrade transapical (TA) access can be performed. The aim of this single-center retrospective study was to evaluate outcomes of patients undergoing AASG through a TA approach. Methods We analyzed all patients undergoing AASG through a TA approach at our institution. Three different devices were used, including Relay Stent-Graft System (Terumo Aortic, UK), Gore Conformable Thoracic Aortic Graft (W. L. Gore & Associates, Inc., USA), and Valiant Thoracic Stent Graft (Medtronic, Ireland). All patients underwent clinical and computed tomographic angiogram (CTA) evaluation before hospital discharge. Results From May 2010 to December 2019, 3 consecutive patients underwent AASG at our institution. Mean age was 69 years. Three different types of endografts were used in 1 patient each. All patients stayed in the intensive care unit for 24 hr and mean hospital stay was 12 days. We did not observe any major adverse event. One patient died of pneumonia 2 months after the procedure and the other 2 patients are alive and in good clinical conditions at a mean follow-up of 56 months. Predischarge CTA showed good anatomic results with no endoleaks in all cases. Conclusions This initial experience shows that AASG is feasible and provides encouraging clinical and anatomic results in selected high-risk patients.
CD19-directed CAR T-cell therapy for treatment of primary CNS lymphoma
Authors: Siddiqi Tanya , Wang Xiuli , Blanchard M. Suzette , Wagner Jamie R. , Popplewell Leslie L. , Budde L. Elizabeth , Stiller Tracey L. , Clark Mary C. , Lim Laura , Vyas Vibhuti , Brown Christine E. , Forman Stephen J. 
Published: September 2021

Abstract
CD19-directed chimeric antigen receptor (CD19CAR) T-cell therapy has been successful in treating several B-cell lineage malignancies, including B-cell non-Hodgkin lymphoma (NHL). This modality has not yet been extended to NHL manifesting in the central nervous system (CNS), primarily as a result of concerns for potential toxicity. CD19CAR T cells administered IV are detectable in cerebrospinal fluid (CSF), suggesting that chimeric antigen receptor (CAR) T cells can migrate from the periphery into the CNS, where they can potentially mediate antilymphoma activity. Here, we report the outcome of a subset of patients with primary CNS lymphoma (PCNSL; n = 5) who were treated with CD19CAR T cells in our ongoing phase 1 clinical trial. All patients developed grade ≥ 1 cytokine release syndrome and neurotoxicity post-CAR T-cell infusion; toxicities were reversible and tolerable, and there were no treatment-related deaths. At initial disease response, 3 of 5 patients (60%; 90% confidence interval, 19-92%) seemed to achieve complete remission, as indicated by resolution of enhancing brain lesions; the remaining 2 patients had stable disease. Although the study cohort was small, we demonstrate that using CD19CAR T cells to treat PCNSL can be safe and feasible. This trial was registered at www.clinicaltrials.gov as #NCT02153580.