bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glucose starvation suppresses gastric cancer through targeting miR-216a-5p/Farnesyl-Diphosphate Farnesyltransferase 1 axis
Authors: Zhao Ruiyang , Cao Bo , Li Hanghang , Li Tian , Xu Xingming , Cui Hao , Deng Huan , Wei Bo 
Published: December 2021

Abstract
Background
Fasting mimic diet is an effect approach for gastric cancer (GC) treatment. Exploring mechanisms of glucose deprivation-mediated GC suppression is required to develop novel therapeutic regimens. Farnesyltransferase 1 (FDFT1), as a novel target in basic research, has been reported to regulate malignant progression in some types of cancer. However, biological functions of FDFT1 in GC are still unclear. This study focused on biological functions of FDFT1 in GC and the association between glucose starvation (GS) and FDFT1.

Methods
The data derived from the Kaplan–Meier Plotter database were collected to identify the relationship between survival time and FDFT1 expression levels of GC patients. Bioinformatic analysis was performed to explore the biological functions of FDFT1. The expression levels of targeted genes and microRNAs (miRNAs) were detected with immunohistochemistry, quantitative real-time PCR and western blot. Malignant behaviors were measured using cell counting, cell counting kit-8, 5-ethynyl-2-deoxyuridine, wound healing, invasion transwell assays in vitro and constructions of subcutaneous and lung-metastatic tumors in vivo. The glycolysis of GC cells was determined by a series of metabolites, including lactate acid, pyruvic acid, ATP production, rates of glucose uptake, extracellular acidification rate and oxygen consumption rate.

Results
FDFT1 was downregulated in GC and negatively correlated with pathological T stage, pathological TNM stage and cancer differentiation. High expression of FDFT1 also indicated better prognosis of GC patients. FDFT1 upregulation attenuated proliferation, migration and invasion of GC. miR-216a-5p was identified as a critical suppressor of FDFT1 expression and miR-216a-5p/FDFT1 axis regulated malignant behaviors and glycolysis of GC cells. GS suppressed malignant behaviors of GC by targeting miR-216a-5p/FDFT1 axis both in vitro and in vivo.

Conclusion
This study illustrated novel mechanisms by which GS effectively suppresses GC. FDFT1 may become a potential prognostic indicator and novel target of GC therapy.
Bio-assisted synthesis of bimetallic nanoparticles featuring antibacterial and photothermal properties for the removal of biofilms
Authors: Nudelman Roman , Gavriely Shira , Bychenko Darya , Barzilay Michal , Gulakhmedova Tamilla , Gazit Ehud , Richter Shachar 
Published: December 2021

AbstractBiofilms are responsible for about considerable amounts of cases of bacterial infections in humans. They are considered a major threat to transplant and chronic wounds patients due to their highly resistant nature against antibacterial materials and due to the limited types of techniques that can be applied to remove them. Here we demonstrate a successful in-situ bio-assisted synthesis of dual functionality nanoparticles composed of Silver and Gold. This is done using a jellyfish-based scaffold, an antibacterial material as the templating host in the synthesis. We further explore the scaffold’s antibacterial and photothermal properties against various gram-negative and positive model bacteria with and without photo-induced heating at the Near-IR regime. We show that when the scaffold is loaded with these bimetallic nanoparticles, it exhibits dual functionality: Its photothermal capabilities help to disrupt and remove bacterial colonies and mature biofilms, and its antibacterial properties prevent the regrowth of new biofilms.
Graphical Abstract
Acidic microenvironment responsive polymeric MOF-based nanoparticles induce immunogenic cell death for combined cancer therapy
Authors: Zhang Xiaoli , Lu Yi , Jia Die , Qiu Wei , Ma Xianbin , Zhang Xingliang , Xu Zhigang , Wen Feiqiu 
Published: December 2021

Abstract
Background
The complex tumor microenvironment and non-targeting drugs limit the efficacy of clinical tumor therapy. For ensuring the accurate delivery and maximal effects of anticancer drugs, it is important to develop innovative drug delivery system based on nano-strategies.

Result
In this study, an intracellular acidity-responsive polymeric metal organic framework nanoparticle (denoted as DIMP) has been constructed, which can co-deliver the chemotherapy agent of doxorubicin (DOX) and phototherapy agent of indocyanine green (ICG) for breast carcinoma theranostics. Specifically, DIMP possesses a suitable and stable nanometer size and can respond to the acidic microenvironment in cells, thus precisely delivering drugs into target tumor sites and igniting the biological reactions towards cell apoptosis. Following in vivo and in vitro results showed that DIMP could be effectively accumulated in tumor sites and induced powerful immunogenic cell death (ICD) effect.

Conclusion
The designed DIMP displayed its effectiveness in combined photo-chemotherapy with auxiliary of ICD effect under a multimodal imaging monitor. Thus, the present MOF-based strategy may offer a potential paradigm for designing drug-delivery system for image-guided synergistic tumor therapy.

Graphical Abstract
The association between allergy and sinusitis: a cross-sectional study based on NHANES 2005–2006
Authors: Li Song , Zhao Chu-Jin , Hua Hong-Li , Deng Yu-Qin , Tao Ze-Zhang 
Published: December 2021

Abstract
Background
The relationship between allergies and sinusitis, though extensively studied, remains poorly defined. While several studies proposed a cause-and-effect relationship between allergy and chronic sinusitis, several others reported the lack of any existing association. This study aimed to investigate the relationship between allergy and sinusitis.

Methods
We conducted a cross-sectional study using a representative sample of the US population from the National Health and Nutrition Examination Survey 2005‒2006 (n  = 7244). A self-reported allergy questionnaire and total and allergen-specific IgE levels were used for analysis. Participants were divided into positive and negative allergy symptoms groups (PAS, NAS, respectively) to eliminate the influence of allergy symptoms on the apparent incidence of sinusitis. Pearson’s chi-square test and the linear regression analysis using Durbin Watson test were used for statistical analysis.

Results
Sinusitis incidence in the PAS group (22.4%; 521/2327) was significantly higher than that in the NAS group (7.1%; 348/4917) [odds ratios (OR)  = 3.788, 95% confidence interval (CI) 3.272‒4.384, P  < 0.001]. sinusitis incidence in non-sensitized and sensitized groups was not statistically different. After controlling for allergy symptoms, there was a negative correlation between sensitization status and the occurrence of sinusitis in the PAS group (OR  = 1.407, 95% CI 1.156‒1.711, P  < 0.01). Increase in serum total IgE levels correlated with decrease in incidence of sinusitis in both PAS and NAS groups. sinusitis incidence was significantly reduced in the PAS group in participants sensitized to allergens such as cockroaches, ragweed, ryegrass, Bermuda grass, oak, birch, and thistle.

Conclusion
Allergy is related to sinusitis incidence. It is likely that sensitization status could reduce the incidence of sinusitis, albeit in an antigen-specific manner.
Exosomes originating from infection with the cytoplasmic single-stranded RNA virus Rift Valley fever virus (RVFV) protect recipient cells by inducing RIG-I mediated IFN-B response that leads to activation of autophagy
Authors: Alem Farhang , Olanrewaju Adeyemi A. , Omole Samson , Hobbs Heather E. , Ahsan Noor , Matulis Graham , Brantner Christine A. , Zhou Weidong , Petricoin Emanuel F. , Liotta Lance A. , Caputi Massimo , Bavari Sina , Wu Yuntao , Kashanchi Fatah , Hakami Ramin M. 
Published: December 2021

Abstract
Background
Although multiple studies have demonstrated a role for exosomes during virus infections, our understanding of the mechanisms by which exosome exchange regulates immune response during viral infections and affects viral pathogenesis is still in its infancy. In particular, very little is known for cytoplasmic single-stranded RNA viruses such as SARS-CoV-2 and Rift Valley fever virus (RVFV). We have used RVFV infection as a model for cytoplasmic single-stranded RNA viruses to address this gap in knowledge. RVFV is a highly pathogenic agent that causes RVF, a zoonotic disease for which no effective therapeutic or approved human vaccine exist.

Results
We show here that exosomes released from cells infected with RVFV (designated as EXi-RVFV) serve a protective role for the host and provide a mechanistic model for these effects. Our results show that treatment of both naïve immune cells (U937 monocytes) and naïve non-immune cells (HSAECs) with EXi-RVFV induces a strong RIG-I dependent activation of IFN-B. We also demonstrate that this strong anti-viral response leads to activation of autophagy in treated cells and correlates with resistance to subsequent viral infection. Since we have shown that viral RNA genome is associated with EXi-RVFV, RIG-I activation might be mediated by the presence of packaged viral RNA sequences.

Conclusions
Using RVFV infection as a model for cytoplasmic single-stranded RNA viruses, our results show a novel mechanism of host protection by exosomes released from infected cells (EXi) whereby the EXi activate RIG-I to induce IFN-dependent activation of autophagy in naïve recipient cells including monocytes. Because monocytes serve as reservoirs for RVFV replication, this EXi-RVFV-induced activation of autophagy in monocytes may work to slow down or halt viral dissemination in the infected organism. These findings offer novel mechanistic insights that may aid in future development of effective vaccines or therapeutics, and that may be applicable for a better molecular understanding of how exosome release regulates innate immune response to other cytoplasmic single-stranded RNA viruses.
Charaterizations of 3D printed re-entrant pattern/aramid knit composite prepared by various tilting angles
Authors: Jung Imjoo , Kim Hyelim , Lee Sunhee 
Published: December 2021

AbstractThis study intended to compare and analyze the Poisson's ratio and mechanical properties of aramid knit (ARNT), 3D printed auxetic re-entrant pattern (3DP-RE), and 2 types of composite fabrics manufactured with ARNT and 3DP-RE. Specimens were manufactured by 3D printing the re-entrant pattern with a CFDM (conveyor fused deposition modeling) 3D printer and TPU (thermoplastic polyurethane) filament, combining with aramid knit in 2 ways. Then, Poisson's ratio, bending, compression, and tensile properties were tested. As a result of Poisson's ratio, 3DP-RE and its 2 types of composite fabric showed negative Poisson's ratio at all angles and deformed stable at 0° and 90° than the bias direction. The bending strength confirmed that the composite fabric showed a lower value. But, the strain at max bending strength was greater than a substrate fabric. At the compression properties, it has been confirmed that compression strength and toughness are improved when manufacturing composite fabrics. As a result of tensile properties, 3DP-RE and composite fabrics were significantly more initial modulus, elongation and toughness than ARNT and were shown to be the largest in gradient 90°. Therefore, it is confirmed that the performance is excellent when fabricated as a 3DP-RE/ARNT composite fabric, and based on the results of studies, we intend to use it as the basic data for composite fabrics of auxetic structure suitable for shoe uppers.
Socio and ethno-cultural embeddedness of transnational Nigerian immigrant entrepreneurs in Ghana
Authors: Antwi Bosiakoh Thomas , Obeng Bernard Acquah 
Published: December 2021

AbstractTransnational Nigerian immigrant entrepreneurs have been in Ghana for a long time, operating by utilizing a wide range of resources available to them. Key among these resources are their own socio and ethno-cultural norms which have yet to be explored in the existing scholarship. We explore these patterns and norms in the articulation of transnational entrepreneurship among these immigrants in Ghana. We do this by relying on qualitative data gathered through in-depth interviews, observations and market conversations—with 41 Nigerian immigrant entrepreneurs in Accra, Kumasi, and Ashaiman. We argue that these transnational Nigerian immigrant entrepreneurs in Ghana are embedded in their own ‘socio and ethno-cultural heritage’. This argument is anchored in multiple logics. First is the notion of transnational entrepreneurial activity that is ethnically and culturally inspired. Secondly, these entrepreneurship activities are inextricably embedded in informality and intensely rely on informal power brokerage system. Thirdly, there is an embeddedness in the entrepreneurs’ own traditional apprenticeship system. These lines of socio and ethno-cultural embeddedness provide useful pathways for understanding not only the operations and future prospects but also the patterns of transnational (mixed) embeddedness of the Nigerian immigrant entrepreneurs in Ghana.
Macrophage activation syndrome in a patient with adult-onset Still’s disease following first COVID-19 vaccination with BNT162b2
Authors: Muench Frédéric , Krusche Martin , Sander Leif Erik , Rose Thomas , Burmester Gerd-Rüdiger , Schneider Udo 
Published: December 2021

Abstract
Background
Adult-onset Still’s disease (AOSD) is an autoinflammatory multi-systemic syndrome. Macrophage activation syndrome (MAS) is a potentially life-threatening complication of AOSD with a mortality rate of 10–20%. Especially viral infection is thought to be a common trigger for development of MAS. On the other hand, the occurrence of MAS following vaccinations is extremely rare and has been described in a few cases after measles or influenza vaccinations and more recently after ChAdOx1 nCoV-19 (COVID-19 viral vector vaccine, Oxford-AZ).

Case presentation
We report the case of a twenty-year-old female with adult-onset Still’s disease (AOSD), who developed a MAS six days after receiving her first COVID-19 vaccine dose of BNT162b2 (mRNA vaccine, BioNTech/Pfizer) with ferritin levels of 136,680 µg/l (ref.: 13–150 µg/l).

Conclusions
To the best of our knowledge, this is the first case report of development of MAS in a patient with preexisting AOSD after vaccination in general, and SARS-CoV-2 vaccination in particular. The new mRNA vaccines have generally shown a reassuring safety profile, but it has been shown that nucleic acids in general, including mRNA can act as pathogen-associated molecular patterns that activate toll-like receptors with extensive production of pro-inflammatory cytokines and further activation of immune cells. Proving an interferon 1 response in our patient directly after vaccination, we think that in this particular case the vaccination might have acted as trigger for the development of MAS. Even if it remains difficult to establish causality in the case of rare adverse events, especially in patients with autoimmune or autoinflammatory conditions, these complications are important to monitor and register, but do not at all diminish the overwhelming positive benefit-risk ratio of licensed COVID-19 vaccines.
An Optimal Approximation for Submodular Maximization Under a Matroid Constraint in the Adaptive Complexity Model
Authors: Balkanski Eric , Rubinstein Aviad , Singer Yaron 
Published: December 2021

An Exponentially Faster Algorithm for Submodular Maximization Under a Matroid Constraint This paper studies the problem of submodular maximization under a matroid constraint. It is known since the 1970s that the greedy algorithm obtains a constant-factor approximation guarantee for this problem. Twelve years ago, a breakthrough result by Vondrák obtained the optimal 1 − 1/e approximation. Previous algorithms for this fundamental problem all have linear parallel runtime, which was considered impossible to accelerate until recently. The main contribution of this paper is a novel algorithm that provides an exponential speedup in the parallel runtime of submodular maximization under a matroid constraint, without loss in the approximation guarantee.
Restaurante Mata Nativa: Adaptação ou Oportunidade em Tempos de Pandemia da Covid-19
Authors: Nascimento Cassio Andre Bayma do , Behling Gustavo , Tutida Alessandra , Pereira Erick , Lana Jailson 
Published: December 2021

Este caso para ensino relata a história do Restaurante Mata Nativa. Tradicional no atendimento à la carte e na integração com a natureza como diferencial competitivo, a trajetória de 15 anos do restaurante evidencia como os processos de desenvolvimento das capacidades de aquisição, assimilação, transformação e aplicação do conhecimento foram essenciais no desenvolvimento do empreendimento e em especial para superação da crise causada pela pandemia da Covid19. Recomenda-se a aplicação deste caso em cursos de Administração, nos níveis de pós-graduação lato sensu ou stricto sensu, em disciplinas de empreendedorismo ou estratégias organizacionais. Objetiva-se que os alunos possam refletir criticamente sobre o processo de desenvolvimento de capacidades para geração de vantagens competitivas e de desempenho organizacional.
Self-care knowledge, attitude and associated factors among outpatients with diabetes mellitus in Arsi Zone, Southeast Ethiopia
Authors: Kassa Rahel Nega , Hailemariam Hana Abera , Habte Mekdes Hailegebreal , Gebresillassie Altayework Mekonnen 
Published: December 2021

Introduction
Diabetes mellitus is a chronic illness that requires continuing medical care and ongoing patient self-management, education and support to prevent acute complications and to reduce the risk of long-term complications. Therefore, this study aims to assess the self-care knowledge, attitude and associated factors among outpatients with diabetes mellitus in Arsi Zone, Southeast Ethiopia.

Materials and methods
A cross sectional study was employed in Arsi Zone, Southeast Ethiopia from April to June 2017 among 290 patients with diabetes mellitus. Structured questionnaire was employed through face to face interview. Bivariate and multivariate regression was done and a statistical significance was declared at p value < 0.05.

Results
Among 290 respondents, 64.8% and 27.6% of them had good knowledge and good attitude towards self-care in this study respectively. Being married (AOR: 3.41, 95% CI: 1.480–8.095), being employed in occupation (AOR: 5.8, 95% CI: 2.26–14.67) and living in higher socioeconomic status (AOR: 2.0, 95% CI: 1.096–3.322) are the independent factors associated to good knowledge of respondents towards self-care whereas living in lower socioeconomic status(AOR: 0.478, 95% CI: 0.262–0.874), having informal education (AOR: 4.002, 95% CI: 1.941–8.254), not having family history of diabetes mellitus (AOR: 0.422, 95% CI: 0.222–0.803) and having short duration of diagnosis (AOR: 3.209, 95% CI: 1.537–6.779) were significantly associated factors to have poor attitude towards self-care.

Conclusion
Majority of the study participants had good knowledge towards diabetes self-care practice while a significant number of the participants had unfavorable attitude towards diabetes self-care. Being married, being employed and living in higher socioeconomic status were the determinant factors of knowledge towards the diabetes self-care practice while having informal education and having short duration of diagnosis were the significant factors associated to the unfavorable attitude towards diabetes self-care practice. Therefore, efforts should be made on enhancing patients’ socioeconomic status and equipping with diabetic self-care centered health information particularly for those patients with short duration of diagnosis.
Does the Intensity of Gadget Use Impact Social and Emotional Development of Children aged 48-72 Months?
Authors: Rukmana Nabila Ilma Nisa , Ainy Fardana Nur , Dewanti Linda , Mujtaba Farah 
Published: December 2021

Purpose –This study aims to analyze the correlation between the intensity of gadget use and the social-emotional development of children aged 48-72 months.Design/methods/approach – The Study uses quantitative research with a cross-sectional study. The sample includes 126 children using a simple random sampling technique at Al-Furqon Kindergarten and Bunda Ghifari Kindergarten Surabaya, Indonesia. The independent variable is the intensity of gadget use which is measured using a questionnaire. The dependent variable is the children’s social-emotional development as measured by the Questionnaire of Problems and Emotional Behavior.Findings – There is a significant correlation between the intensity of gadget usage and the social-emotional development of children aged 48-72 months (p-value < 0.05). High-intensity gadget use will increase their social-emotional development in the referral category, which means it requires treatment by the experts.Research implications/limitations - The result of this study supports the theory that high intensity of gadget usage on children will affect their social and emotional development. This study only focuses on children’s social and emotional development without examining another developmental variable that may affect the study results.Practical implications – Parents are expected to play a role in supervising and limiting the use of gadgets on children to avoid the negative impacts.Originality/value –This study contributes to the literature by showing the effect of gadget use on children’s social and emotional development.
Paper type Research paper
Naturalna regulacja poczęć wyrazem odpowiedzialnego rodzicielstwa. Interdyscyplinarna argumentacja o. Karola Meissnera w Memoriale Krakowskim
Authors: Olczyk Maciej 
Published: December 2021

Artykuł przypomina doniosły wkład o. Karola Meissnera w sformułowanie argumentacji na rzecz promocji metod naturalnej regulacji poczęć w kontekście przygotowań do opublikowania encykliki Humanae vitae. Argumentacja ta została zaprezentowana w dokumencie znanym jako Memoriał Krakowski, który został opracowany z inicjatywy Karola Wojtyły przez środowisko krakowskich teologów, etyków i lekarzy. Wartością tego dokumentu było i jest pod dzień dzisiejszy nie tylko jego personalistyczne ukierunkowanie oraz interdyscyplinarność, ale także wskazanie alternatywy dla działań antykoncepcyjnych w postaci naturalnej regulacji poczęć, za którą przemawiają wyłożone w dokumencie argumenty teologiczne, etyczne oraz medyczne.
A vanishing theorem for the canonical blow-ups of Grassmann manifolds
Authors: Fang Hanlong , Zhu Songhao 
Published: December 2021

AbstractLet 𝒯s,p,nbe the canonical blow-up of the Grassmann manifoldG(p,n) constructed by blowing up the Plücker coordinate subspaces associated with the parameters. We prove that the higher cohomology groups of the tangent bundle of 𝒯s,p,nvanish. As an application, 𝒯s,p,nis locally rigid in the sense of Kodaira-Spencer.