bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality Assessment of Selected Ground Water Sources Around a University Teaching Hospital Liquid Waste Treatment Plant
Authors: Adegbe Elijah Abakpa , Maina Lois Riyo , Adeniji Shola Elijah , Fasanya Opeoluwa Olusola , Okoduwa Stanley Irobekhian Reuben 
Published: April 2021

Abstract
Background:The study conducted a comprehensive assessment of the quality of selected groundwater sources around the liquid waste treatment plant of Ahmadu University Teaching Hospital Shika, Nigeria. Water samples were collected from four (4) hand-dug wells following standard procedures, ten (10) physicochemical parameters and seven (7) heavy metals were analyzed.Results: All the physicochemical parameters studied were within the WHO specified limits except for DO which was less and turbidity which was higher. Heavy metals were found in the all the groundwater sources that were studied. However, the concentration of some heavy metals exceeded the specified limits recommended by the World Health Organization (WHO). The heavy metal presence in the groundwater sources may be connected to human activities such as waste disposal containing these metals around the groundwater sources and liquid waste from the hospital which can may have seeped into the wells.Conclusion: By implication, this study shows that the hand-dug wells were not safe for drinking. It is recommended that wells be sited away from dumpsites and waste treatment plants and effluents from waste treatment plants should also be properly treated before their subsequent discharge into the environment. This study has generated a baseline data that will be useful in monitoring heavy metal pollution.
Healthcare Providers’ Implementation of Patient-Centred Outcome Measures (PROMs) and Patient-Reported Experience Measures (PREMs) in Practice A Protocol for a Mixed Method Systematic Review
Authors: Wolff Angela C , Dresselhuis Andrea , Hejazi Samar , Dixon Duncan , Gibson Deborah , Howard A Fuchsia , Liva Sarah , Astle Barbara , Reimer-Kirkham Sheryl , Noonan Vanessa K , Edwards Lisa 
Published: April 2021

Abstract
Background: Substantial literature has highlighted the importance of patient-reported outcome and experience measures (PROMs and PREMs, respectively) to collect clinically relevant information to better understand and address what matters to patients. The purpose of this systematic review is to synthesize the evidence about strategies for implementing individual-level PROMs and PREMs data by healthcare providers in their everyday practice.Methods: This mixed method systematic review protocol describes the design of our synthesis of the peer-reviewed research evidence (i.e., qualitative, quantitative, and mixed methods), systematic reviews, organizational implementation projects, expert opinion, and grey literature. Keyword synonyms for “PROMs,” PREMs,” and “implementation” will be used to search eight databases with limiters of English from 2009 to 2019. Study selection criteria includes implementation at the point-of-care by healthcare providers in any practice setting. Eligible studies will be critically appraised using validated tools (e.g., Joanna Briggs Institute). Guided by the review questions, data extraction and synthesis will occur simultaneously to identify biographical information and methodological characteristics as well as classify study findings related to implementation processes and strategies. As part of the narrative synthesis approach, two frameworks will be utilized: (a) Consolidated Framework for Implementation Research (CFIR) to identify influential factors of PROMs and PREMs implementation and (b) Expert Recommendations for Implementing Change (ERIC) to illicit strategies. Data management will be undertaken using NVivo 12TM. Discussion: Data from PROMs and PREMs are critical to adopt a person-centred approach to healthcare. Findings from this review will guide subsequent phases of a larger project that includes interviews and a consensus-building forum with end users to create guidelines for implementing PROMs and PREMs at the point of care. Systematic Review Registration: PROSPERO CRD42020182904
Analysis of the ultimate water resources carrying capacity in Yancheng, China
Authors: Dong Zengchuan , Yang Guang , Feng Shengnan , Ma Jiayi , Li Bing 
Published: April 2021

Abstract
Unreasonable development and utilization of resources has caused serious environmental problems, especially water shortage and water pollution. Determining the largest population size and economic scale that water resources can support without destroying the ecological environment in a region, that is, ultimate water resources carrying capacity (UWRCC), helps to realize the sustainable utilization of water resources. UWRCC is a variable value which is easily affected by natural conditions, technical level and economic status. This study proposes a UWRCC research method that combines multi-objective optimization and scenario analysis. This method draws a diagram of UWRCC result sets based on multi-scenario UWRCC calculation, through which UWRCC values under different specific technical and economic levels are easily and quickly obtained. This method has been applied to Yancheng in this study and the quantitative relationship between technical level, economic level and UWRCC of Yancheng was analyzed. Taking Yancheng as the research area, this study analyzes the quantitative relationship between the technical level, economic level and UWRCC of Yancheng. The results show that according to existing government planning, Yancheng's water resources will be sufficient to support socioeconomic development. But the districts of Yandu, Tinghu, and Binghai will experience population and gross domestic product overloading in future years. In addition, a diagram of the UWRCC sets of Yancheng was obtained and it provides a reference for local water resources management.
Enhancement of the electro-activated persulfate process in dye removal using graphene oxide nanoparticle
Authors: Ayati Bita , Ghorbani Zeinab 
Published: April 2021

Abstract
This study aimed to improve the speed of the electrochemical process by graphene oxide nanoparticle as a current accelerator in Acid Blue 25 removal from aqueous solutions. To do so, the effect of different parameters including pH, dye concentration, sodium persulfate concentration, the ratio of sodium persulfate to iron (II) sulfate concentration, current density, and the distance between electrodes was investigated on dye removal. Under optimal conditions of pH = 5, dye concentration = 200 mg/L, sodium persulfate concentration = 500 mg/L, iron (II) sulfate concentration = 100 mg/L, current density = 16.67 mA/cm2, and electrode distance = 2 cm, 95% of dye was removed after 60 min in the electro-activated persulfate process; while the modified electro-activated persulfate process achieved 95% dye removal after only 40 min under the same conditions. This system was able to remove 90% of dye after 60 min at a higher concentration (300 mg/L). Also, the modified electro-activated persulfate process obtained the removal of 80% of COD, and 54% of TOC after 180 min in the mentioned conditions, for the dye concentration of 300 mg/L.
Recent Advances in the Medicinal Chemistry of Phenothiazines, New Anticancer and Antiprotozoal Agents
Authors: González-González Alonzo , Vazquez-Jimenez Lenci K. , Paz-González Alma D. , Bolognesi María Laura , Rivera Gildardo 
Published: April 2021

Background:
Molecules with a phenothiazine scaffold have been considered versatile
organic structures with a wide variety of biological activities, such as antipsychotic, anticancer,
antibacterial, antifungal, antiviral, anti-inflammatory, antimalarial, and trypanocidal,
etc. It was first discovered in the 19th century as a histochemical dye, phenothiazine methylene
blue. Since then, its derivatives have been studied, showing new activities; moreover,
they have also been repurposed.

Objective:
This review aims to describe the main synthetic routes of phenothiazines and, particularly,
the anticancer and antiprotozoal activities reported during the second decade of the
2000s (2010 - 2020).

Results:
Several studies on phenothiazines against cancer and protozoa have revealed that
these compounds show IC50 values in the micromolar and near nanomolar range. The structural
analyses have revealed that compounds bearing halogens or electron-withdrawing
groups at 2-position have favorable anticancer activity. Phenothiazine dyes have shown a
photosensitizing activity against trypanosomatids at a micromolar range. Tetra and pentacyclic
azaphenothiazines are structures with a high broad-spectrum anticancer activity.

Conclusion:
The phenothiazine scaffold is favorable for developing anticancer agents, especially
those bearing halogens and electron-withdrawing groups bound at 2-position with enhanced
biological activities through a variety of aromatic, aliphatic and heterocyclic substituents
in the thiazine nitrogen. Further studies are warranted along these investigation lines to
attain more active anticancer and antiprotozoal compounds with minimal to negligible cytotoxicity.
Factors Determining the Metal Ion Binding Ability and Selectivity of Hydroxamate-Based Compounds
Authors: Farkas Etelka , Bíró Linda , Buglyó Péter 
Published: April 2021

:
There has been a long tradition for a broad spectrum of applications of both natural
and synthetic hydroxamic acids and derivatives. Even nowadays, a huge number of
newly designed representatives (from different monohydroxamate-based compounds to
siderophore conjugates) are used to develop potential drug candidates with desired activities.
Since these compounds are effective metal-chelating agents, their biological roles
and actions as well as their various applications, e.g., in the medicinal practice, are all in
direct correlation with their metal complexation. Consequently, the knowledge of the stoichiometry
and binding modes of metal complexes with hydroxamic acid-based ligands,
their thermodynamic parameters, and speciation profiles in solution are crucial for scientists
working in any of the above-mentioned fields.

:
This review, in addition to presenting a few factors, which might affect the metal-binding
capabilities of these organic ligands, displays and summarizes the different parameters
typically used to give the stoichiometry, composition, and stability of the species formed
in a solution equilibrium system in measurable concentration. Discussion of the possibilities
for quantitative comparison of metal-binding effectivity and selectivity of various hydroxamic
acids with each other by using solution equilibrium data is also the focus of
this publication.
The Role of Coffee and its Bioactive Components in Platelet Function and
Aging
Authors: Arauna Diego , Navarrete Simón , Devia Matías , Rodríguez Lyanne , Reyes Lemuel , Wehinger Sergio , Silva-Weiss Andrea , Palomo Iván , Fuentes Eduardo 
Published: April 2021

:
Cardiovascular diseases (CVD) are known to be the world's leading cause of death and different
factors are known to increase the risk of death, including aging, mainly due to increased oxidative
stress and inflammation observed in older people. Acute myocardial infarctions and cerebrovascular
accidents belong to CVD, and are the ones that cause the most deaths and disabilities, where greater
platelet activation plays an important role in pathophysiology. These diseases are more prevalent in older
people, which have a clear relationship with increased platelet function and are strongly related to aging.
Platelet function is affected by diet, which varies in its requirements and characteristics according to age.
Coffee belongs to the family of diet elements that can alter platelet function and an increase in coffee
consumption with advancing age, and a U-shaped correlation with the risk of CVD have been reported.
However, the effect of coffee consumption and its bioactive compounds on platelet function and aging
presents controversial evidence, and therefore, a complex effect is not fully elucidated in the cardiovascular
system. This review focuses on the relationship between coffee consumption (and its constituent
bioactive compounds), and platelet function, and aging.
STRATEGI PENINGKATAN PENDAPATAN ASLI DAERAH MELALUI RETRIBUSI SEKTOR PARIWISATA (Studi Kasus Kawasan Wisata Dataran Tinggi Dieng Kabupaten Wonosobo)
Authors: Novianti Reni , M. Baga Lukman , Falatehan A. Faroby 
Published: April 2021

Kabupaten Wonosobo memiliki potensi pada sektor pariwisata, salah satunya objek wisata Dataran Tinggi Dieng. Pariwisata merupakan salah satu sektor yang berpotensi memberikan kontribusi terhadap Pendapatan Asli Daerah (PAD). Akan tetapi, kontribusi PAD Wonosobo dalam pembiayaan belanja daerah kurang dari 15 persen. Oleh karena itu, tujuan dilaksanakannya penelitian ini adalah untuk menganalisis kondisi objek wisata terhadap beberapa atribut dengan menggunakan analisis IPA; mengestimasi nilai willingness to pay pengunjung dengan menggunakan Contingent Valuation Method (CVM); serta merumuskan strategi peningkatan PAD Kabupaten Wonosobo melalui peningkatan retribusi objek wisata Dataran Tinggi Dieng dengan menggunakan analisis SWOT. Hasil analisis IPA menunjukkan atribut kondisi jalan menuju kawasan wisata, kebersihan, pelayanan, promosi, penanganan keluhan pengunjung, kemacetan, tempat pembuangan sampah, fasilitas toilet dan musholla menjadi prioritas utama untuk diperbaiki. Sedangkan dari hasil analisis CVM diperoleh nilai WTP sebesar Rp16 513 per orang. Berdasarkan hasil analisis tersebut serta hasil wawancara yang telah dilakukan, dapat teridentifikasi faktor-faktor yang menjadi kekuatan, kelemahan, peluang dan ancaman yang dituangkan dalam matriks SWOT. Terdapat lima strategi yang berperan dalam peningkatan retribusi objek wisata dataran tinggi dieng yaitu: 1) Meningkatkan kerjasama dalam pengelolaan dan pengembangan sumberdaya wisatayang memiliki daya tarik; 2) Membangun sistem yang terintegrasi; 3) membangun dan memperbaiki sarana dan fasilitas umum; 4) memperbaiki akses menuju objek wisata; dan 5) merumuskan peraturan yang mengatur tentang pariwisata, pengelolaan objek wisata beserta elemen-elemennya.
APLIKASI ANALISIS SWOT KUANTITATIF UNTUK FORMULASI STRATEGI PENGEMBANGAN PARIWISATA PERDESAAN DI KAWASAN LERENG MERAPI, DAERAH ISTIMEWA YOGYAKARTA
Authors: Purwohandoyo Joni , Lubis Bobby Tumpal , Saputra Okta Fajar 
Published: April 2021

Kawasan lereng Merapi bagian selatan merupakan salah satu kawasan strategis di DIY. Kawasan ini memiliki potensi yang cukup beragam, salah satunya adalah desa-desa wisata yang tersebar di kawasan ini. Penelitian ini bertujuan untuk mengkaji strategi pengembangan desa-desa wisata dengan menggunakan metode SWOT kuantitatif. Terdapat 12 (dua belas) desawisata yang berada pada kuadran I, 1 (satu) desa wisata pada kuadran II, 2 (dua) desa wisata dikuadran IV dan tidak ada yang berada di kuadran III. Strategi penguatan potensi internal (daya tarik, aksesibilitas, infrastruktur, pengelolaan) dan peningkatan kapasitas eksternal (pemasaran, jejaring investasi dan pengurangan resiko bencana) merupakan strategi pokok untuk mendorong peningkatan perkembangan desa-desa wisata tersebut. Untuk desa wisata pada kuadran II dan IV (Pancoh, Dukuh, Garongan), aspek internal dan eksternal perlu semakin intensif untuk diperkuat. Diperlukan upaya yang serius dan berkelanjutan untuk pengembangan ketiga desa wisata tersebut.
STRATEGI PENGEMBANGAN PARIWISATA MELALUI MEDIA
Authors: Hilman Yusuf Adam 
Published: April 2021

Pembangunan pariwisata di Jawa Timur bisa dijadikan sebagai salah satu contoh, bagaimana pengelolaannya menggunakan beberapa strategi, yang bisa diukur dan juga dievaluasi secara berkesimbungan, diantaranya: Membuat kebijakan pariwisata yang terintegrasi di daerah mulai tingkat Kabupaten/kota hingga pedesaan, supaya stakeholder, masyarakat, dan pengusaha (Private sector) bisa bersinergi, dalam proses pembuatan kebijakan sehingga nantinya kebijakan yang dibuat, bisa kuat dan dukunganpun mengalir dari semua pihak, Membangun Brand Tourism untuk mengembangkan wisata lokal, Membuat event wisata tahunan, sebagai bentuk publikasi dalam upaya untuk memperkenalkan potensi daerah, Membangun sarana transportasi, jalan, dan angkutan untuk mempermudah aksesbilitas, para pelancong guna mencapai destinasi wisata yang dituju. Hasilnya bisa kita saksikan, bagaimana Provinsi Jawa Timur Akhirnya berhasil, mengembangkan daerahnya dengan potensi yang dimiliki, dengan bukti bahwa ada peningkatan pengunjung ke Jawa Timur, serta tingginya perolehan pendapatan dari sektor wisata, membangun band Image serta meembuat even wisata menjadi kunci penting, yang membuat geliat pariwisata di Jawa Timur banyak menarik simpatik wisatawan baik regional maupun internasional.
ANALISIS OFF STREET PARKING DAN ON STREET PARKING DI OBYEK WISATA GOA GONG
Authors: Sulistiani Sulistiani 
Published: April 2021

Kabupaten Pacitan dikenal dengan “Kota 1001 Goa” dan salah satu ikonnya adalah Goa Gong. Ketersediaan fasilitas parkir yang memadai merupakan salah satu faktor yang menentukan tingkat kunjungan wisatawan. Banyaknya kendaraan yang parkir di badan jalan terjadi karena kapasitas ruang parkir yang tersedia tidak mencukupi. Penelitian ini bertujuan untuk mengevaluasi fasilitas parkir di Obyek Wisata Goa Gong menggunakan Program Auto Parkir. Analisis fasilitas parkir dilakukan pada off-street parking. Analisis parkir dengan bantuan program Autoparkir. Berdasarkan hasil penelitian ketersediaan fasilitas parkir di Obyek Wisata Goa Gong masih belum memadai sehingga diperlukan penambahan kapasitas ruang parkir, terutama pada hari minggu pada parkir mobil dan bus, dimana kapasitas parkir yang tersedia sekitar 200 SRP, sedangkan sesuai dengan pedoman parkir untuk tempat rekreasi dengan luas 17 Ha seharusnya disediakan 300 SRP. Prioritas penanganan masalah fasilitas parkir adalah penambahan kapasitas parkir, sedangkan alternatif lain adalah dengan manajemen parkirmelalui pembatasan durasi parkir dan tarif parkir.
Forecasting the Dynamics of Energy Consumption in the City of Sevastopol Using Neural Network Algorithms
Authors: Kotelnikov D. Y. , Kuznetsov P. N. , Kuvshinov V. V. , Yakimovich B. A. , Oleynikov A. M. 
Published: April 2021

Мировое потребление электрической энергии с каждым годом заметно возрастает, что приводит к повышению интереса крупных потребителей и производителей электроэнергии к такой процедуре, как прогнозирование энергопотребления. Информация, полученная в результате прогнозирования, может быть использована для рационального распределения текущей нагрузки во времени, а также корректного расчета перспективной нагрузки; помимо этого становится возможным уменьшение продолжительности пиковых нагрузок, что позволит повысить надежность энергопотребления. Благодаря результатам прогноза компании – производители электроэнергии смогут выстроить более точную экономическую модель развития и принять решение о целесообразности расширения уже имеющейся инфраструктуры. Из вышеуказанного следует, что прогноз энергопотребления позволит уменьшить финансовые потери компаний – производителей и потребителей электроэнергии.Предложена методика выявления типовых профилей суточной динамики энергопотребления, основывающаяся на методах нейросетевого анализа и нейросетеваой классификации. Выявленные типовые профили в дальнейшем стали базисом для проведения процедуры прогнозирования энергопотребления. Профили представлены в виде графиков суточной динамики энергопотребления, что позволяет наглядно и точно оценивать особенности энергопотребления для каждого из фидеров распределительной сети. Также описаны промежуточные этапы, которые были осуществлены для выявления типовых профилей. Проведена процедура прогнозирования энергопотребления, основывающаяся на использовании выявленных типовых профилей, а также оценка ее достоверности.
The Effect of Form AP on Auditor Liability when Engagement Partner Disclosure Shows a History of Restatements
Authors: Mowchan Michael , Reckers Philip M. J. 
Published: April 2021

SYNOPSISEngagement partner disclosures required by Form AP allow litigants to associate audit partners with both current and past restatements. We investigate how this information and audit firm interventions to restore audit quality impact audit firm liability in litigation stemming from a partner's second client restatement. Interestingly, we do not find that a partner's association with a current and past restatement alone increases audit firm liability. However, we do find that jurors interpret firm interventions to restore audit quality as indicators that the partner contributed to the second audit failure and that firm oversight was inadequate. Specifically, we find that both requiring a probationary engagement co-partner after an initial restatement and partner dismissal after a second restatement increase juror assessments of firm liability. Collectively, our findings suggest Form AP presents a catch-22, whereby firm interventions to restore audit quality are expected by regulators but increase liability in subsequent litigation settings.Data Availability: Available upon request from the authors.
Does Client Cyber-Breach Have Reputational Consequences for the Local Audit Office?
Authors: Asthana Sharad C , Kalelkar Rachana , Raman K. K. 
Published: April 2021

SYNOPSIS
We examine whether the public disclosure of a client cyber-breach hurts the reputation of the engagement office of the incumbent auditor. Prior research suggests that alleged client misconduct (even if unrelated to accounting) can hurt the auditor's reputation and bargaining position vis-à-vis other clients. In contrast, in a client cyber-breach, the client is the victim of misconduct rather than perpetrator of the misconduct. Still, for the 100 largest breaches during 2005–2018, we find evidence of a loss in the perceived value of the audit for the non-breach clients of that local audit office. For our sample of all breaches during 2005–2018, our results indicate a decline in the bargaining position for the incumbent audit office. We contribute to the literature by documenting that the negative effects of a cyber-breach are not limited to the breached client but spillover to the local audit office.
Evaluation of torque moment in esthetic brackets from bendable alloy wires
Authors: Nakano Taiji , Nakajima Akira , Watanabe Hiroto , Osada Ayaka , Namura Yasuhiro , Yoneyama Takayuki , Tanaka Eiji , Motoyoshi Mitsuru 
Published: April 2021

ABSTRACTObjectivesTo examine the torque moment that occurs between esthetic brackets and bendable alloy (stainless steel [SS], titanium-molybdenum [Ti-Mo], and titanium-niobium [Ti-Nb]) wires.Materials and MethodsThis study examined ceramic (CR), zirconium oxide (ZC), polycarbonate (PC), and conventional metallic brackets (MT) (upper, 0.018-inch and 0.022-inch slots) combined with SS, Ti-Mo, and Ti-Nb wires using elastic module ligation. The torque moments delivered by various wire and bracket combinations were measured using a torque gauge apparatus. The wire torque angles at 5–40° were examined.ResultsThe torque value increased in the order of CR, ZC, MT, and PC brackets for both 0.018-inch and 0.022-inch slots. The fracture points of the CR and ZC brackets combined with SS and Ti-Mo wires were approximately more than 30° and 35°, respectively. No fracture points were detected in the combination of ZC brackets and Ti-Nb wires.ConclusionsThe current study identified the material characteristics of CR, ZR, and PC brackets during torque tooth movements. The present results demonstrate a characteristic combined effect between different esthetic brackets and bendable alloy wires.