bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automatic detection of procedural knowledge in robotic-assisted surgical texts
Authors: Bombieri Marco , Rospocher Marco , Dall’Alba Diego , Fiorini Paolo 
Published: April 2021

Abstract
Purpose
The automatic extraction of knowledge about intervention execution from surgical manuals would be of the utmost importance to develop expert surgical systems and assistants. In this work we assess the feasibility of automatically identifying the sentences of a surgical intervention text containing procedural information, a subtask of the broader goal of extracting intervention workflows from surgical manuals.

Methods
We frame the problem as a binary classification task. We first introduce a new public dataset of 1958 sentences from robotic surgery texts, manually annotated as procedural or non-procedural. We then apply different classification methods, from classical machine learning algorithms, to more recent neural-network approaches and classification methods exploiting transformers (e.g., BERT, ClinicalBERT). We also analyze the benefits of applying balancing techniques to the dataset.

Results
The architectures based on neural-networks fed with FastText’s embeddings and the one based on ClinicalBERT outperform all the tested methods, empirically confirming the feasibility of the task. Adopting balancing techniques does not lead to substantial improvements in classification.

Conclusion
This is the first work experimenting with machine / deep learning algorithms for automatically identifying procedural sentences in surgical texts. It also introduces the first public dataset that can be used for benchmarking different classification methods for the task.
Myocardial Involvement in COVID-19: an Interaction Between Comorbidities and Heart Failure with Preserved Ejection Fraction. A Further Indication of the Role of Inflammation
Authors: Zaccone Gregorio , Tomasoni Daniela , Italia Leonardo , Lombardi Carlo Mario , Metra Marco 
Published: April 2021

Abstract
Purpose of the review
Coronavirus Disease 2019 (COVID-19) and cardiovascular (CV) disease have a close relationship that emerged from the earliest reports. The aim of this review is to show the possible associations between COVID-19 and heart failure (HF) with preserved ejection fraction (HFpEF).

Recent findings
In hospitalized patients with COVID-19, the prevalence of HFpEF is high, ranging from 4 to 16%, probably due to the shared cardio-metabolic risk profile. Indeed, comorbidities including hypertension, diabetes, obesity and chronic kidney disease — known predictors of a severe course of COVID-19 — are major causes of HFpEF, too. COVID-19 may represent a precipitating factor leading to acute decompensation of HF in patients with known HFpEF and in those with subclinical diastolic dysfunction, which becomes overt. COVID-19 may also directly or indirectly affect the heart. In otherwise healthy patients, echocardiographic studies showed that the majority of COVID-19 patients present diastolic (rather than systolic) impairment, pulmonary hypertension and right ventricular dysfunction. Such abnormalities are observed both in the acute or subacute phase of COVID-19. Cardiac magnetic resonance reveals myocardial inflammation and fibrosis in up to the 78% of patients in the chronic phase of the disease.

Summary
These findings suggest that COVID-19 might be a novel independent risk factor for the development of HFpEF, through the activation of a systemic pro-inflammatory state. Follow-up studies are urgently needed to better understand long-term sequelae of COVID-19 inflammatory cardiomyopathy.
Chronic renal comorbidities in pyoderma gangrenosum: a retrospective cohort study
Authors: Kridin Khalaf , Solomon Arieh , Britva Rimma Laufer , Bitan Dana Tzur , Cohen Arnon D. 
Published: April 2021

AbstractThe coexistence of pyoderma gangrenosum (PG) and chronic renal comorbidities has been reported anecdotally. We aimed to assess the bidirectional association between PG and the following chronic renal comorbidities: chronic renal failure (CRF), dialysis, kidney transplantation (KT), and other kidney diseases (OKD). That is to evaluate (i) the risk of the aforementioned diseases among patients with PG (ii) and the odds of PG after a diagnosis of renal comorbidities. A population-based retrospective cohort study was conducted comparing PG patients (n=302) with age-, sex-, and ethnicity-matched control subjects (n=1497) with regard to incident cases of renal comorbidities. A case-control design was additionally adopted to estimate the odds of PG in those with a preexisting history of renal comorbidities. Adjusted hazard ratios (HRs) and adjusted odds ratios (ORs) were estimated by Cox regression and logistic regression, respectively. Patients with PG demonstrated an increased risk of CRF (adjusted HR, 3.68; 95% CI, 2.72–5.97), dialysis (adjusted HR, 27.79; 95% CI, 3.24–238.14), and OKD (adjusted HR, 2.71; 95% CI, 1.55–4.74). In addition, the odds of PG were increased after the diagnosis of CRF (adjusted OR, 2.34; 95% CI, 1.33–4.11), KT (adjusted OR, 5.03; 95% CI, 1.01–25.12), and OKD (adjusted OR, 1.69; 95% CI, 1.04–2.74). Patients with a dual diagnosis of PG and renal diseases presented with PG at an older age and had a higher prevalence of comorbid conditions. In conclusion, a bidirectional association exists between PG and chronic renal conditions. Awareness of this comorbidity may be of benefit for physicians managing patients with PG.
Nasal Dermoids in Children: Factors Influencing the Distant Result
Authors: Kotowski Michal , Adamczyk Paulina , Szydlowski Jaroslaw 
Published: April 2021

AbstractThe aim of the study was to present a single institution’s treatment strategy for nasal dermoids and to identify factors influencing distant results. The study covered 24 surgically treated pediatric patients with nasal dermoids (NDs). The medical data concerning demographics, preoperative local inflammations and surgical procedures, form of the abnormality, imaging, surgical techniques, and a role of osteotomies and reconstructions were analyzed. The recurrence rates and distant aesthetic outcomes were assessed. The surgical approach included vertical incision in 21 patients, the external rhinoplasty approach in 2 cases, and bicoronal incision in 1 child. The intracranial extension was confirmed in 6 patients. Seven out of 8 cases with preoperative local inflammations and 3 out of 4 with secondary fistulization were < 4 years old. Nine patients required osteotomies. Three children required reconstruction of the nasal skeleton. None of the distant cosmetic results was described as hideous or unsatisfactory. The incidence of local inflammatory complications is unrelated to the age of the patients. The distant aesthetic result depends on both the initial extent of the disease and preoperative local conditions or interventions. Prompt surgical intervention is highly recommended.
Trophoblast Cell Surface Antigen 2 (Trop-2) Protein is Highly Expressed in Salivary Gland Carcinomas and Represents a Potential Therapeutic Target
Authors: Wolber Philipp , Nachtsheim Lisa , Hoffmann Franziska , Klußmann Jens Peter , Meyer Moritz , von Eggeling Ferdinand , Guntinas-Lichius Orlando , Quaas Alexander , Arolt Christoph 
Published: April 2021

AbstractTreatment options for unresectable, recurrent or metastatic salivary gland carcinomas (SGC) are scarce. Trophoblast cell surface antigen 2 (Trop-2) is a transmembrane glycoprotein that is involved in a variety of oncogenic cell signaling pathways. Its potential as a target for the antibody–drug conjugate sacituzumab govitecan has already been demonstrated in different tumor entities. The United States Food and Drug Administration approved this antibody–drug conjugate for the treatment of metastatic triple-negative breast cancer. Here, we aimed to investigate Trop-2 protein expression in different entities of SGCs. We retrospectively reviewed the medical records of all patients that underwent surgery for a primary SGC in a tertiary referral center between 1990 and 2014. Immunohistochemical (IHC) staining for Trop-2 was performed and rated as negative, weak, moderate or high using a semiquantitative score. Additionally, representative cases were analyzed using MALDI-mass spectrometry (MS) imaging to confirm the IHC results. The cohort consisted of 114 tumors of the parotid gland (90.4%) and submandibular gland (9.6%). It mainly included mucoepidermoid, salivary duct and adenoid cystic carcinomas. In IHC samples, 44% showed high, 38% moderate and 10% weak expression rates of Trop-2. MALDI-MS imaging confirmed the presence of Trop-2 protein in 80% of the tested tumor samples. This is the first study to demonstrate that several types of SGC express Trop-2 with variable intensity. Since there are currently few systemic treatment options for advanced SGCs, Trop-2 represents a promising target for further clinical studies, for instance, with sacituzumab govitecan.
Multivariate analysis of potentially toxic elements in surface waters in Ethiopia
Authors: Aschale Minbale , Sileshi Yilma , Kelly-Quinn Mary , Hailu Dereje 
Published: April 2021

AbstractThe Akaki River and its tributaries, in the city of Addis Ababa, are polluted by potentially toxic elements (PTEs) (Sb, Zn, Cd, As, Hg, Cu, Pb, Fe, V, Ni, Co, Mn, Cr, B, Sr and Ba) in varying degrees due to the significantly fast urban expansion and the industrial activities. The water samples collected from twenty-six different locations or sampling sites along the River and some of its tributaries were analyzed by ICP-MS to determine PTEs. The multivariate component analysis was used to evaluate the relationship and interdependency among the PTEs. The results showed that the mean concentrations for most of PTEs exceeded the recommended limits of drinking and irrigation water quality guidelines. A strong and positive relationship was observed among many of PTEs in the river water indicating common sources. The concentrations of many PTEs in the study area exceeded those previously reported and also varied with site or location, signifying localized contributions of the different contaminants associated with municipal, domestic, industrial, hospitals, garages and other activities. These findings of this study should help highlight and focus water quality management on key PTEs of concern and prioritize efforts to mitigate their release into surface waters in the city. Given the potential health implications of the PTEs mitigation measures should be sought as a matter of urgency by the relevant authorities in Ethiopia.
Optimizing the ultrasonic-assisted extraction of antioxidants from Ulva lactuca algal biomass using factorial design
Authors: Rashad Sayed , El-Chaghaby Ghadir , Lima Eder C. , Simoes dos reis Glaydson 
Published: April 2021

AbstractUltrasonic-assisted extraction (UAE) is increasingly emerging as a highly effective extraction technique. This extraction technique is affected by several experimental factors. The present work aimed to optimize the ultrasonic-assisted extraction of antioxidants from Ulva lactuca (sea lettuce), widespread macroalgae growing along the Mediterranean coast. In this respect, a full-factorial design (23) was employed to assess the effect of three different factors at two levels and their interactions on the extraction of antioxidants from sea lettuce algal biomass. The studied factors were extraction solvent, time of extraction, and temperature. The two levels chosen for extraction solvent were 100% ethanol and 50% ethanol, for the sonication time (1 h and 3 h) and temperature (25 °C and 40 °C). All experiments were done using an ultrasonic bath, and the biomass to solvent ratio was kept at 1:5. Total antioxidant capacity and quercetin concentration were set as the two responses for optimum output. The results showed that the temperature and solvent were the dominating factors that significantly affect the extraction process. The optimum extraction parameters were extraction time of 1 h, 50% ethanol, and temperature of 25 °C. Under these conditions, the maximum value for TAA was calculated as 2166.51 mg of ascorbic acid equivalent per gram (mg/g of AAE), and quercetin showed a maximum calculated value of 42.5 mg/g with combined desirability of 0.91 for the two responses. The present study results indicate that U. lactuca can be used as a source of antioxidants and phenolic compounds that can be applied in food and medicine at optimum extraction conditions.
Graphical abstract
Diversity and composition of moss guilds on uprooted trees in Central European mountain forests: effects of uprooting components and environmental variables
Authors: Staniaszek-Kik Monika , Żarnowiec Jan , Stefańska-Krzaczek Ewa 
Published: April 2021

AbstractKey messageThe size of the structural components of the root–pit–mound complex was crucial for high moss species richness. Root plates, pits, and mounds were similar in terms of moss species composition, which was mostly determined by forest type.ContextUprooted trees may be colonized by different terricolous mosses including common species and specialists.AimsThe main aim of the present study was to analyze the relative effects of tree uprooting on mosses.MethodsWe used the parametric ZIGLMM and GLMM models to explain the richness and abundance of the moss species and double constrained correspondence analysis (dc-CA) to analyze species composition.ResultsThe size of components of RPM complexes had a positive effect on moss species richness. The species cover of mosses was positively correlated with elevation. Species richness was partly dependent on forest type and species cover on component type and age of the RPM complex. The most important factor diversifying species composition was the type of forest. Species traits were also related to forest communities.ConclusionUprooted trees are worth keeping in forest community, especially large ones. Moreover, the conservation value of uprooted trees in woodlands is higher if they are dispersed in different forest types.
Is Physical Activity Associated with Less Depression and Anxiety During the COVID-19 Pandemic? A Rapid Systematic Review
Authors: Wolf Sebastian , Seiffer Britta , Zeibig Johanna-Marie , Welkerling Jana , Brokmeier Luisa , Atrott Beatrice , Ehring Thomas , Schuch Felipe Barreto 
Published: April 2021

Abstract
Background
The Covid-19 pandemic is affecting the entire world population. During the first spread, most governments have implemented quarantine and strict social distancing procedures. Similar measures during recent pandemics resulted in an increase in post-traumatic stress, anxiety and depression symptoms. The development of novel interventions to mitigate the mental health burden are of utmost importance.

Objective
In this rapid review, we aimed to provide a systematic overview of the literature with regard to associations between physical activity (PA) and depression and anxiety during the COVID-19 pandemic.

Data Source
We searched major databases (PubMed, EMBASE, SPORTDiscus, and Web of Science) and preprint servers (MedRxiv, SportRxiv, ResearchGate, and Google Scholar), for relevant papers up to 25/07/2020.

Study Eligibility Criteria
We included observational studies with cross-sectional and longitudinal designs. To qualify for inclusion in the review, studies must have tested the association of PA with depression or anxiety, using linear or logistic regressions. Depression and anxiety must have been assessed using validated rating scales.

Study Appraisal and Synthesis Methods
Effect sizes were represented by fully adjusted standardized betas and odds ratios (OR) alongside 95% confidence intervals (CI). In case standardized effects could not be obtained, unstandardized effects were presented and indicated.

Results
We identified a total of 21 observational studies (4 longitudinal, 1 cross-sectional with retrospective analysis, and 16 cross-sectional), including information of 42,293 (age 6–70 years, median female = 68%) participants from five continents. The early evidence suggests that people who performed PA on a regular basis with higher volume and frequency and kept the PA routines stable, showed less symptoms of depression and anxiety. For instance, those reporting a higher total time spent in moderate to vigorous PA had 12–32% lower chances of presenting depressive symptoms and 15–34% of presenting anxiety.

Conclusion
Performing PA during Covid-19 is associated with less depression and anxiety. To maintain PA routines during Covid-19, specific volitional and motivational skills might be paramount to overcome Covid-19 specific barriers. Particularly, web-based technologies could be an accessible way to increase motivation and volition for PA and maintain daily PA routines.
Central limit theorem of Brownian motions in pinched negative curvature
Authors: KIM JAELIN 
Published: April 2021

AbstractWe prove the central limit theorem of random variables induced by distances to Brownian paths and Green functions on the universal cover of Riemannian manifolds of finite volume with pinched negative curvature. We further provide some ergodic properties of Brownian motions and an application of the central limit theorem to the dynamics of geodesic flows in pinched negative curvature.
Trends in body mass index among ever-married Bangladeshi women, 2004–14: evidence from nationally representative population-based surveys
Authors: Islam Md. Rafiqul , Hossain Md. Sabbir , Khan Md. Mostaured Ali , Rahman Md. Shafiur 
Published: April 2021

Abstract
Both high and low body weight are associated with adverse health risk for both mother and children. Studies evaluating trends in the coverage of undernutrition and overnutrition among ever-married Bangladeshi women are limited. The objective of the present study is to assess the trends and develop future projections of body weight status among Bangladeshi women and to estimate the smoothed mean BMI by women's age for the national level and across urban and rural areas. Data from Bangladesh Demographic and Health Surveys conducted between 2004 and 2014 were used. The annual rate of change in the prevalence of underweight, overweight, and obesity, and smoothed age-specific mean BMI was estimated. During 2004–14, the prevalence of underweight reduced with an annual rate of 5⋅9 % at the national level, while the prevalence of overweight and obesity increased with an annual rate of 8⋅6 and 9⋅6 %, respectively. With the recent trends, the prevalence of underweight is expected to reduce from 11⋅9 % in 2020 to 6⋅5 % by 2025. In 2020, the prevalence of overweight and obesity were 30⋅0 and 6⋅9 %, respectively, which are projected to increase to 38⋅5 and 9⋅0 %, respectively, by 2025, if present trends continue. By 2030, the prevalence of overweight was predicted to be much higher in urban areas (44⋅7 %) compared with rural areas (36⋅5 %). Multifaceted nutrition programme should be introduced for rapid reduction of undernutrition and to halt the rise of the prevalence of overweight and obesity.
Against the Flow: Differentiating Between Public Opposition to the Immigration Stock and Flow
Authors: Margalit Yotam , Solodoch Omer 
Published: April 2021

AbstractVast research on immigration lumps together native citizens' attitudes toward two different groups: the immigrant stock of non-naturalized resident aliens, and the immigrant flow, that is, the future arrival of foreigners seeking to enter and live in the country. Does popular opposition to immigration distinguish between the two, and if so, how? This article analyzes theoretically the reasons the stock and flow might induce different views among natives, and presents experimental evidence from the United States showing that natives are systematically more accepting of the former. The analysis indicates that this ‘stock premium’ partly stems from a sense of moral obligation toward people residing in the country. Replicating two widely cited experiments, the study shows that the stock–flow distinction has important implications for the interpretation of earlier findings on immigration attitudes, and for understanding voter preferences regarding policies designed to curtail immigration.
The Metaphoricity of Being and the Question of Sameness: Heidegger and Zwicky
Authors: Hensby Eben 
Published: April 2021

ABSTRACTI draw on Heidegger and Zwicky to challenge the notion that underlying divergent perspectives of an entity there must be something that is ‘the same’; instead, sameness is disclosed within particular world-disclosures. I focus on Heidegger's concepts of world and truth as foundation for thinking about different human worlds. I introduce Zwicky's work on gestalts, internal relations, truth as asymptotic limit, and metaphors; the concept of metaphoricity of Being helps us think through how it is that no thing underlies the different perspectives of a phenomenon, and yet that there are limits for disclosures.
Setiya on Consequentialism and Constraints
Authors: Cox Ryan , Hammerton Matthew 
Published: April 2021

AbstractIt is widely held that agent-neutral consequentialism is incompatible with deontic constraints. Recently, Kieran Setiya has challenged this orthodoxy by presenting a form of agent-neutral consequentialism that he claims can capture deontic constraints. In this reply, we argue against Setiya's proposal by pointing to features of deontic constraints that his account fails to capture.
Exploring the Jungle of Intuitionistic Temporal Logics
Authors: BOUDOU JOSEPH , DIÉGUEZ MARTÍN , FERNÁNDEZ-DUQUE DAVID , KREMER PHILIP 
Published: April 2021

AbstractThe importance of intuitionistic temporal logics in Computer Science and Artificial Intelligence has become increasingly clear in the last few years. From the proof-theory point of view, intuitionistic temporal logics have made it possible to extend functional programming languages with new features via type theory, while from the semantics perspective, several logics for reasoning about dynamical systems and several semantics for logic programming have their roots in this framework. We consider several axiomatic systems for intuitionistic linear temporal logic and show that each of these systems is sound for a class of structures based either on Kripke frames or on dynamic topological systems. We provide two distinct interpretations of “henceforth”, both of which are natural intuitionistic variants of the classical one. We completely establish the order relation between the semantically defined logics based on both interpretations of “henceforth” and, using our soundness results, show that the axiomatically defined logics enjoy the same order relations.