bluuebunny/crossref_metadata_2025_split huggingface dataset:
White Matter Hyperintensity Burden and Collateral Circulation in Large Vessel Occlusion Stroke
Authors: Derraz Imad , Abdelrady Mohamed , Gaillard Nicolas , Ahmed Raed , Cagnazzo Federico , Dargazanli Cyril , Lefevre Pierre-Henri , Corti Lucas , Riquelme Carlos , Mourand Isabelle , Gascou Gregory , Bonafe Alain , Arquizan Caroline , Costalat Vincent 
Published: September 2021

Background and Purpose:
White matter hyperintensity (WMH), a marker of chronic cerebral small vessel disease, might impact the recruitment of leptomeningeal collaterals. We aimed to assess whether the WMH burden is associated with collateral circulation in patients treated by endovascular thrombectomy for anterior circulation acute ischemic stroke.

Methods:
Consecutive acute ischemic stroke due to anterior circulation large vessel occlusion and treated with endovascular thrombectomy from January 2015 to December 2017 were included. WMH volumes (periventricular, deep, and total) were assessed by a semiautomated volumetric analysis on fluid-attenuated inversion recovery–magnetic resonance imaging. Collateral status was graded on baseline catheter angiography using the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology grading system (good when ≥3). We investigated associations of WMH burden with collateral status.

Results:

A total of 302 patients were included (mean age, 69.1±19.4 years; women, 55.6%). Poor collaterals were observed in 49.3% of patients. Median total WMH volume was 3.76 cm
3
(interquartile range, 1.09–11.81 cm
3
). The regression analyses showed no apparent relationship between WMH burden and the collateral status measured at baseline angiography (adjusted odds ratio, 0.987 [95% CI, 0.971–1.003];
P
=0.12).

Conclusions:
WMH burden exhibits no overt association with collaterals in large vessel occlusive stroke.
Prediction for cloud spacing confirmed using stereo cameras
Authors: Öktem Ruşen , Romps David M. 
Published: September 2021

AbstractUsing three years of the Clouds Optically Gridded by Stereo (COGS) product, the mean cloud base, cloud top, cloud width, and cloud spacing are described with respect to their seasonal and/or diurnal evolution at the Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) site. In addition to confirming and extending prior results, the data show that the effective diameter of shallow cumuli are approximately equal to the height above ground of the lifting condensation level (LCL). Furthermore, the cloud spacing is found to closely match a prediction by Thuburn and Efstathiou for the horizontal scale of the largest unstable eddies in an unsheared convective boundary layer.
Simulation research on the protection performance of fall protection net at the end of truck escape ramp
Authors: Qin Pinpin , Hou Xiaolei , Zhang Shaokun , Zhang Shunfeng , Huang Junming 
Published: September 2021

Introduction: Although the fall protection net installed at the end of the truck escape ramp has a protective effect on trucks and drivers, but lacks sufficient theoretical basis and verification method. Objectives: The primary objective of this paper was to design a fall protection net that meets the regulations and research its protection performance. Methods: The finite-element method was used to design the overall size, material, mesh length, mesh type, shape, and supporting structure of the fall protection net installed at the end of truck escape ramp, then dummy and truck models were used to impact the fall protection net to verify the rationality of the design. After the design completed, the truck model was used to impact the fall protection net twice to research the cumulative protection performance. Results: A fall protection net with a width of 6000 mm, a span of 6000 mm, a depth of 5196 mm, a mesh length of 150 mm, a mesh type of diamond mesh, a shape of 60-degree V-shaped, a supporting structure of steel pipe supporting has a better effect on energy absorption and protection. Within the two consecutive impacts, the residual plastic deformation and stress of the fall protection net generated in the first impact severely affect the protection performance in the second impact. Conclusion: It is feasible to use the finite-element method to design and research the fall prevention net installed at the end of the truck escape ramp, and the fall protection net can indeed protect the trucks and drivers, and it should be inspected and maintained after impact to ensure the protective performance in subsequent use.
A Case of Clinically Diagnosed ANCA Negative Granulomatosis With Polyangiitis
Authors: Walkden Alexander , Salem Mohammed , Stavrakas Marios , Khalil Hisham 
Published: September 2021

Significance Statement Granulomatosis with polyangitis (GPA) is a systemic necrotizing vasculitis comprising of inflammation of small and medium-sized vessels. 1 It typically presents with involvement of the upper and lower airways as well as the kidneys. If left untreated, end-organ damage may occur. Hematological investigations typically demonstrate the presence of antinuclear cytoplasmic antibodies (ANCA). 2 Here, we discuss an unusual presentation of ANCA negative GPA, presenting initially with nasal symptoms.
A combined protocol for improving reconstruction of scrotal skin avulsions: The experience of the University Hospital Center of Foggia
Authors: Lembo Fedele , Cecchino Liberato Roberto , Parisi Domenico , Portincasa Aurelio 
Published: September 2021

Objective: Scrotal degloving injuries are rare and constitute a challenge for reconstructive surgeons. The authors describe their successful experience with a combined reconstruction protocol using an acellular dermal matrix (ADM), negative pressure wound therapy (NPWT) and a split-thickness skin graft (STSG), and the retrospective assessment of overall morbidity and esthetic outcomes. Methods: Five consecutive patients underwent a wide excision of necrotic scrotal skin and a reconstruction procedure using a combined protocol with NPWT, Pelnac®, and STSG. The efficacy of this treatment was determined by assessing overall morbidity and esthetic outcomes with the Vancouver Scar Scale (VSS). Results: The combined protocol made it possible to create an environment that promoted wound healing, improved graft intake, and gage the reconstructed site a more natural look. No significant problems were observed. Satisfactory cosmetic and functional results were obtained in all patients as shown by VSS scores obtained. Conclusions: We believe that this combined protocol is a reliable alternative to flaps and should be considered an excellent option in scrotal reconstruction, especially in critical patients.
Recreational Motorized Vehicle Use Under the Influence of Alcohol or Drugs Significantly Increases Odds of Craniofacial Injury
Authors: Sorenson Thomas J. , Rich Matthew D. , Lamba Abhinav , Deitermann Annika , Barta Ruth J. , Schubert Warren 
Published: September 2021

Study Design: Cross-sectional study. Objective: Concurrent substance-use, including alcohol and drugs, increases the risks of many recreational activities. Our purpose was to determine the relationship between substance use and craniofacial injuries in a large population of patients experiencing trauma due to recreational motorized vehicle use. Methods: We report a cross-sectional study of patients reported to the National Electronic Injury Surveillance System (NEISS) from January 1, 2019 to December 31, 2019, in the United States. Patients were included in our study if they were evaluated in the emergency department (ED) for a recreational motorized vehicle-related injury. Primary outcome was craniofacial injury. Results: There were a total of 6,485 adult patients who experience an injury after recreational motorized vehicle trauma reported by NEISS-participating EDs during the study period. Of this, 1,416 (21.8%) patients had a craniofacial injury, and 201 patients with craniofacial injuries were under the influence of alcohol/drugs (201/1,416; 14.2%). Injured patients under the influence of alcohol/drugs experienced greater odds of sustaining a general craniofacial injury (OR 2.50, 95% CI: 2.07-3.01, P < .0001), including craniofacial fracture (OR: 2.98, 95% CI: 2.01-4.40, P < .0001), laceration (OR: 2.19, 95% CI: 1.51-3.16, P < .00001) and internal injury (OR: 2.33, 95% CI: 1.84-2.95, P < .00001) than injured patients not under the influence. Conclusions: Using recreational motorized vehicles under the influence of alcohol or drugs is not safe and increases the likelihood of craniofacial injuries, including fractures, lacerations, and internal injuries. As operating these recreational motorized vehicles under the influence is illegal, the law should be strictly enforced to prevent the occurrence of these injuries. Additional undertakings to increase helmet usage would be valuable.
Platelet FcγRIIA-induced serotonin release exacerbates the severity of transfusion-related acute lung injury in mice
Authors: El Mdawar Marie-Belle , Maître Blandine , Magnenat Stéphanie , Tupin Florian , Jönsson Friederike , Gachet Christian , de la Salle Henri , Hechler Beatrice 
Published: September 2021

AbstractTransfusion-related acute lung injury (TRALI) remains a major cause of transfusion-related fatalities. The mechanism of human antibody-mediated TRALI, especially the involvement of the Fcγ receptors, is not clearly established. Contrary to mice, human platelets are unique in their expression of the FcγRIIA/CD32A receptor, suggesting that our understanding of the pathogenesis of antibody-mediated TRALI is partial, as the current murine models incompletely recapitulate the human immunology. We evaluated the role of FcγRIIA/CD32A in TRALI using a humanized mouse model expressing the FcγRIIA/CD32A receptor. When challenged with a recombinant chimeric human immunoglobulin G1/mouse anti–major histocompatibility complex class I monoclonal antibody, these mice exhibited exacerbated alveolar edema and higher mortality compared with wild-type (WT) mice. Unlike in WT mice, monocytes/macrophages in CD32A+ mice were accessory for TRALI initiation, indicating the decisive contribution of another cell type. Platelet activation was dramatically increased in CD32A+ animals, resulting in their increased consumption and massive release of their granule contents. Platelet depletion prevented the exacerbation of TRALI in CD32A+ mice but did not affect TRALI in WT animals. By blocking platelet serotonin uptake with fluoxetine, we showed that the severity of TRALI in CD32A+ mice resulted from the serotonin released by the activated platelets. Furthermore, inhibition of 5-hydroxytryptamine 2A serotonin receptor with sarpogrelate, before or after the induction of TRALI, abolished the aggravation of lung edema in CD32A+ mice. Our findings show that platelet FcγRIIA/CD32A activation exacerbates antibody-mediated TRALI and provide a rationale for designing prophylactic and therapeutic strategies targeting the serotonin pathway to attenuate TRALI in patients.
Management of acquired hemophilia A: results from the Spanish registry
Authors: Mingot-Castellano María-Eva , Pardos-Gea Josep , Haya Saturnino , Bastida-Bermejo José-María , Tàssies Dolors , Marco-Rico Ana , Núñez Ramiro , García-Candel Faustino , de Mora María-Carmen Fernández-Sanchez , Soto Inmaculada , Álvarez-Román María-Teresa , Asenjo Susana , Carrasco Marina , Lluch-García Rafael , Martín-Antorán José-Manuel , Rodríguez-Alén Agustín , Roselló Elena , Torres-Miñana Laura , Marcellini-Antonio Shally , Moretó-Quinana Ana , Rodríguez-García José-Antonio , Aguinaco-Culebras Reyes , Alonso-Escobar Nieves , Cervero-Santiago Carlos , Fernández-Mosteirín Núria , Martínez-Badás María-Paz , Pérez-Sánchez Montserrat , Pérez-Montes Rocío , Rodríguez-González Ramón , Uribe-Barrientos Marisol , Caparrós-Miranda Isabel Socorro , Iglesias-Fernández Miriam , Baena Ángela , Rodríguez-López Manuel , Sebrango-Sandia Ana , Vázquez-Fernández Irene , Marco Pascual ,   on behalf of the Acquired Haemophilia Spanish Registry of the Spanish Society of ThrombosisHaemostasis (SETH)
Published: September 2021

Abstract
The Spanish Acquired Hemophilia A (AHA) Registry is intended to update the status of AHA in Spain. One hundred and fifty-four patients were included and retrospectively followed for a median of 12 months. Patients were predominantly male (56.3%), with median age at diagnosis of 74 years. AHA was more frequently idiopathic (44.1%) and autoimmune disorder-associated (31.7%). Thirty-four percent of patients were on antithrombotic therapy at diagnosis. Hemostatic treatment was used in 70% of patients. Recombinant activated factor VII was more frequently infused (60.3% vs 20.6% activated prothrombin complex concentrate). Only 1 patient did not achieve control of hemorrhage. Complete remission (CR) was achieved by 84.2% of cases after immunosuppressive therapy. Steroids alone were less efficient than the other strategies (68.2% vs 87.2%, P = .049), whereas no differences existed among these (steroids/cyclophosphamide, 88.5%, vs steroids/calcineurin inhibitors, 81.2%, vs rituximab-based regimens, 87.5%). Female sex and high inhibitor levels influenced CR negatively. Thirty-six deaths (23.8%) were reported. Main causes of death were infection (15 patients, 9.9%) and hemorrhage (5 patients, 3.3%). All hemorrhage-related and half the infection-related deaths occurred within 2 months of diagnosis. Prior antithrombotic therapy was inversely associated with survival, irrespective of age. Median age of nonsurvivors was significantly higher (79 vs 73 years in survivors). Patients dying of infection were older than the other nonsurvivors (85 vs 78 years). In summary, fatal infection in the first months is common in our series. Antithrombotic therapy is associated with mortality. Particular care should be taken to avoid misdiagnosis.
Incidence and risk factors associated with bleeding and thrombosis following chimeric antigen receptor T-cell therapy
Authors: Johnsrud Andrew , Craig Juliana , Baird John , Spiegel Jay , Muffly Lori , Zehnder James , Tamaresis John , Negrin Robert , Johnston Laura , Arai Sally , Shizuru Judith , Lowsky Robert , Meyer Everett , Weng Wen-Kai , Shiraz Parveen , Rezvani Andrew , Latchford Theresa , Mackall Crystal , Miklos David , Frank Matthew , Sidana Surbhi 
Published: September 2021

AbstractBleeding and thrombotic events are an emerging toxicity associated with chimeric antigen receptor (CAR) therapies. To determine their incidence, we retrospectively analyzed consecutive adult patients (N = 127) with large B-cell lymphoma (LBCL) or B-cell acute lymphoblastic leukemia (B-ALL) treated from 2017 through 2020 with axicabtagene ciloleucel (axi-cel; n = 89) or a bispecific CD19/CD22 CAR (n = 38). Twelve (9.4%) and 8 (6.3%) patients developed bleeding and thrombosis within the first 3 months, respectively. In the axi-cel subgroup, these occurred in 11.2% and 6.7%, respectively. Bleeding occurred between days 8 and 30 (median, 17.5) and thrombosis between days 2 and 91 (median, 29). Bleeding sites included genitourinary, soft tissue, intracranial, gastrointestinal, and pulmonary and were associated with features of consumptive coagulopathy. On univariate analysis, patients with bleeding were older, had lower baseline platelets (86 × 103/μL vs 178 × 103/μL; P &lt; .01), lower platelet and fibrinogen nadirs , and elevated lactate dehydrogenase. Immune effector cell (IEC)–associated neurotoxicity syndrome (ICANS) grade ≥3 was associated with increased bleeding (50% vs 15%; P = .01), thrombosis (50% vs 16%; P = .04), prothrombin time prolongation, hypofibrinogenemia, and elevated D-dimer. Low pretreatment platelet counts were associated with bleeding in a multivariate logistic regression model. Patients with thrombocytopenia or severe ICANS are at increased risk of bleeding and should be closely monitored, particularly within the first month after CAR therapy. Future studies in larger cohorts should assess risk factors for systemic coagulopathies in CAR T therapy, including their association with neurotoxicity.
Depleting SOX2 improves ischemic stroke via lncRNA PVT1/microRNA-24-3p/STAT3 axis
Authors: Chen Zhongjun , Fan Tieping , Zhao Xusheng , Zhang Zhichen 
Published: September 2021

AbstractObjectivesStudies have widely explored in the filed of ischemic stroke (IS) with their focus on transcription factors. However, few studies have pivoted on sex determining region Y-box 2 (SOX2) in IS. Thus, this study is launched to figure out the mechanisms of SOX2 in IS.MethodsRat middle cerebral artery occlusion (MCAO) was established as a stroke model. MCAO rats were injected with depleted SOX2 or long non-coding RNA plasmacytoma variant translocation 1 (PVT1) to explore their roles in neurological deficits, cerebral water content, neuron survival, apoptosis and oxidative stress. The relationship among SOX2, PVT1, microRNA (miR)-24-3p and signal transducer and activator of transcription 3 (STAT3) was verified by a series of experiments.ResultsSOX2, PVT1 and STAT3 were highly expressed while miR-24-3p was poorly expressed in cerebral cortex tissues of MCAO rats. Depleted SOX2 or PVT1 alleviated brain injury in MCAO rats as reflected by neuronal apoptosis and oxidative stress restriction, brain water content reduction, and neurological deficit and neuron survival improvements. Overexpression of PVT1 functioned oppositely. Restored miR-24-3p abolished PVT1 overexpression-induced brain injury in MCAO rats. SOX2 directly promoted PVT1 expression and further increased STAT3 by sponging miR-24-3p.ConclusionThis study presents that depleting SOX2 improves IS via PVT1/miR-24-3p/STAT3 axis which may broaden our knowledge about the mechanisms of SOX2/PVT1/miR-24-3p/STAT3 axis and provide a reference of therapy for IS.
Rollover Prevention and Motion Planning for an Intelligent Heavy Truck
Authors: Jin Zhilin , Li Jingxuan , Wang Hong , Li Jun , Huang Chaosheng 
Published: September 2021

AbstractIt is very necessary for an intelligent heavy truck to have the ability to prevent rollover independently. However, it was rarely considered in intelligent vehicle motion planning. To improve rollover stability, a motion planning strategy with autonomous anti rollover ability for an intelligent heavy truck is put forward in this paper. Considering the influence of unsprung mass in the front axle and the rear axle and the body roll stiffness on vehicle rollover stability, a rollover dynamics model is built for the intelligent heavy truck. From the model, a novel rollover index is derived to evaluate vehicle rollover risk accurately, and a model predictive control algorithm is applicated to design the motion planning strategy for the intelligent heavy truck, which integrates the vehicle rollover stability, the artificial potential field for the obstacle avoidance, the path tracking and vehicle dynamics constrains. Then, the optimal path is obtained to meet the requirements that the intelligent heavy truck can avoid obstacles and drive stably without rollover. In addition, three typical scenarios are designed to numerically simulate the dynamic performance of the intelligent heavy truck. The results show that the proposed motion planning strategy can avoid collisions and improve vehicle rollover stability effectively even under the worst driving scenarios.
Adhesion pathway proteins and risk of atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis
Authors: Mendez Israel J. , Manemann Sheila M. , Bell Elizabeth J. , Larson Nicholas B. , Decker Paul A. , Guerrero Marco A. , Hanson Naomi Q. , Heckbert Susan R. , Pankow James S. , Tsai Michael Y. , Bielinski Suzette J. 
Published: September 2021

Abstract
Background
The cellular adhesion pathway has been suggested as playing an important role in the pathogenesis of atrial fibrillation (AF). However, prior studies that have investigated the role of adhesion pathway proteins in risk of AF have been limited in the number of proteins that were studied and in the ethnic and racial diversity of the study population. Therefore we aimed to study the associations of fifteen adhesion pathway proteins with incident AF in a large, diverse population.

Methods
Multi-Ethnic Study of Atherosclerosis participants from four races/ethnicities (n = 2504) with protein levels measured were followed for incident AF (n = 253). HGF protein was measured on Exam 1 samples (N = 6669; AF n = 851). Cox proportional hazards regression was used to assess the association of AF with 15 adhesion pathway proteins. Bonferroni correction was applied to account for multiple comparisons.

Results
After adjusting for potential confounding variables (age, sex, race/ethnicity, height, body mass index, systolic blood pressure, antihypertension therapy, diabetes status, current smoker, current alcohol use, and total and HDL cholesterol), and accounting for multiple testing (P < 0.05/15 = 0.0033), circulating levels of the following proteins were positively associated with a higher risk of AF: MMP-2 (HR per standard deviation increment, 1.27; 95% CI 1.11‒1.45), TIMP-2 (HR 1.28; 95% CI 1.12‒1.46), VCAM-1 (HR 1.32; 95% CI 1.16‒1.50), and SLPI (HR 1.22; 95% CI 1.07‒1.38). The association between proteins and AF did not differ by race/ethnicity.

Conclusions
Circulating levels of MMP-2, TIMP-2, VCAM-1, and SLPI were positively associated with an increased risk of incident AF in a diverse population. Our findings suggest that adhesion pathway proteins may be important risk predictors of AF.
Sarcopenia predicts adverse outcomes in an elderly population with coronary artery disease: a systematic review and meta-analysis
Authors: Xue Qiqi , Wu Jie , Ren Yan , Hu Jiaan , Yang Ke , Cao Jiumei 
Published: September 2021

Abstract
Background
The development of sarcopenia is attributed to normal aging and factors like type 2 diabetes, obesity, inactivity, reduced testosterone levels, and malnutrition, which are factors of poor prognosis in patients with coronary artery disease (CAD). This study aimed to perform a meta-analysis to assess whether preoperative sarcopenia can be used to predict the outcomes after cardiac surgery in elderly patients with CAD.

Methods
PubMed, Embase, the Cochrane library, and Web of Science were searched for available papers published up to December 2020. The primary outcome was major adverse cardiovascular outcomes (MACE). The secondary outcomes were mortality and heart failure (HF)-related hospitalization. The random-effects model was used. Hazard ratios (HRs) with 95% confidence intervals (95%CIs) were estimated.

Results
Ten studies were included, with 3707 patients followed for 6 months to 4.5 ± 2.3 years. The sarcopenia population had a higher rate of MACE compared to the non-sarcopenia population (HR = 2.27, 95%CI: 1.58–3.27, P < 0.001; I2 = 60.0%, Pheterogeneity = 0.02). The association between sarcopenia and MACE was significant when using the psoas muscle area index (PMI) to define sarcopenia (HR = 2.86, 95%CI: 1.84–4.46, P < 0.001; I2 = 0%, Pheterogeneity = 0.604). Sarcopenia was not associated with higher late mortality (HR = 2.15, 95%CI: 0.89–5.22, P = 0.090; I2 = 91.0%, Pheterogeneity < 0.001), all-cause mortality (HR = 1.35, 95%CI: 0.14–12.84, P = 0.792; I2 = 90.5%, Pheterogeneity = 0.001), and death, HF-related hospitalization (HR = 1.37, 95%CI: 0.59–3.16, P = 0.459; I2 = 62.0%, Pheterogeneity = 0.105). The sensitivity analysis revealed no outlying study in the analysis of the association between sarcopenia and MACE after coronary intervention.

Conclusion
Sarcopenia is associated with poor MACE outcomes in patients with CAD. The results could help determine subpopulations of patients needing special monitoring after CAD surgery. The present study included several kinds of participants; although non-heterogeneity was found, interpretation should be cautious.