bluuebunny/crossref_metadata_2025_split huggingface dataset:
SIAAA‐C: A student interactive assistant android application with chatbot during COVID‐19 pandemic
Authors: Sweidan Saadeh Z. , Abu Laban Sarah S. , Alnaimat Njood A. , Darabkh Khalid A. 
Published: April 2021

AbstractNowadays, smartphone applications (apps) are literally used in all life aspects, improving the quality of different services in addition to saving time and effort. However, the majority of currently used apps in different universities around the world are limited in their features and not very popular among students who may suffer to get useful information using traditional guiding methods. However, the importance of these apps is constantly increasing, especially in times of crises like the COVID‐19 pandemic during which people were forced to work from home and the human interaction was reduced to its minimal degree. In this paper, we present a Student Interactive Assistant Android Application with Chatbot (SIAAA‐C), which is basically a personal electronic guide that is used by students to get various and effective academic services. The app has a number of useful features including a campus map, multiple types of notifications, and most important, an efficient built in chatbot that responds to both Arabic and English written queries and covers a wide range of academic topics ranging from basic to complex. Even more, SIAAA‐C was designed to have Arabic and English interfaces to be used in the University of Jordan (UoJ), which has one of the biggest campuses in the Arabic area with more than 40,000 local and foreign students. Moreover, SIAAA‐C was practically tested in a real‐life environment by a group of UoJ students who were selected from different faculties during the pandemic peak period and the feedbacks were very promising, based on the outcomes of an evaluation survey that was answered by 102 students after a 1‐month test period.
Chemical Composition of Magonia pubescens Essential Oils and Gamma‐Radiation Effects on Its Constituents and Cytotoxic Activity in Leukemia and Breast Cancer Model
Authors: Moraes Acácio R. A. , Camargo Karen C. , Simões Maria O. M. , Ferraz Vany P. , Pereira Márcio T. , Evangelista Fernanda C. G. , Sabino Adriano P. , Duarte Lucienir Pains , Alcântara Antônio F. C. , de Sousa Grasiely F. 
Published: April 2021

AbstractMagonia pubescens A. St.‐Hil. is a Brazilian species often used in ethnopharmacology for wound and pain healing and seborrhea treatment. For the first time, essential oils (EOs) obtained from M. pubescens inflorescences were studied. The plant materials (Montes Claros, Brazil, 2018) were submitted to different gamma‐radiation doses and their chemical compositions were analyzed by GC/MS and GC‐FID. The cytotoxic activity of the EOs was evaluated against K562 and MDA‐MB‐231 cancer cell lines. A total of 30 components were identified, being 24 compounds detected for the first time in M. pubescens. The main obtained components were hotrienol (35.9 %), cis‐linalool oxide (17.0 %) and trans‐linalool oxide (10.2 %). The chemical composition of the EO was slightly affected by the applied radiation doses. Irradiated and non‐irradiated EOs showed cytotoxic activity against both cell lines and the non‐irradiated EO sample was the most active against the K562 cell lines (IC50=22.10±1.98).
Association of acute kidney injury with outcomes in patients undergoing percutaneous left atrial appendage closure
Authors: Nazir Salik , Ahuja Keerat Rai , Ariss Robert W. , Hassanein Mohamed , Schurmann Paul , Koneru Srikanth , Afshar Hamid , Giorgberidze Irakli , Moukarbel George V. , Jneid Hani 
Published: April 2021

AbstractObjectivesUsing a large nationally representative database, we aimed to examine risk factors for acute kidney injury (AKI) and its association with outcomes in patients undergoing percutaneous left atrial appendage closure (LAAC).BackgroundPrevious small‐scale studies have reported poor outcomes with AKI following percutaneous LAAC.MethodsWe queried the Nationwide Readmission Database to identify LAAC procedures performed from 2016 to 2017. Multivariable logistic and linear regression models were used to identify risk factors for AKI and determine the association between AKI and clinical outcomes. The primary outcome of interest was in‐hospital mortality.ResultsOf 20,703 patients who underwent LAAC during the study period, 1,097 (5.3%) had a diagnosis of AKI. Chronic kidney disease, non‐elective admission, coagulopathy, weight loss, prior coronary artery disease, heart failure, diabetes mellitus, and anemia were independently associated with an increased risk of AKI after LACC. In patients undergoing LAAC, AKI was associated with an increased risk of in‐hospital mortality (adjusted odds ratio [aOR], 16.01; 95% CI, 8.48–30.21), stroke/transient ischemic attack (aOR, 2.50; 95% CI, 1.69–3.70), systemic embolization (aOR, 3.78; 95% CI, 1.64–8.70), bleeding/transfusion (aOR, 1.96; 95% CI, 1.50–2.56), vascular complications (aOR, 3.53; 95% CI, 1.94–6.42), pericardial tamponade requiring intervention (aOR, 6.83; 95% CI, 4.37–10.66), index length of stay (adjusted parameter estimate, 7.46; 95% CI, 7.02–7.92), and 180‐day all‐cause readmissions (aOR, 1.43; 95% CI, 1.09–1.88).ConclusionAKI in the setting of LAAC is uncommon but is associated with poor clinical outcomes. Further studies are needed to determine if a similar association exists for long‐term outcomes.
A Stable Fluorine‐Containing Solid Electrolyte Interface toward Dendrite‐Free Lithium‐Metal Anode for Lithium‐Sulfur Batteries
Authors: Chen Yuchao , Mao Yangyang , Hao Xiaoqian , Cao Yongan , Wang Wenju 
Published: April 2021

AbstractLithium‐sulfur (Li−S) batteries are considered to be a representative of the next generation of lithium‐ion batteries due to their high theoretical specific capacity (2600 Wh ⋅ Kg−1), and they have been extensively researched. However, the formation of lithium dendrites during the discharge process continuously consumes the electrolyte and the lithium anode, resulting in an increase in the cell‘s internal resistance and a capacity loss. Herein, we added an organic‐inorganic polymer hexafluoro‐cyclo‐triphosphazene (HFPP) to the electrolyte, which showed lower interfacial resistance and more effective lithium‐ion deposition. The lone‐pair electrons of the nitrogen atoms in HFPP promote the uniform diffusion of lithium ions and its 2D structure also enhances the mechanical stability of the solid electrolyte interphase (SEI) and inhibits the formation of lithium dendrites. Based on the regulating effect, the cells using HFPP as electrolyte additives showed an excellent discharge capacity of 1095 mAh ⋅ g−1 at 0.5 C and a reversible capacity of 763 mAh ⋅ g−1 after 200 cycles, indicating that HFPP is an effective additive for the protection of the lithium anode and cycling stability of Li−S batteries.
Electrocatalytic Oxidation of Water by OH−‐ and H2O‐Capped IrOx Nanoparticles Electrophoretically Deposited on Graphite and Basal Plane HOPG: Effect of the Substrate Electrode**
Authors: Mirbagheri Naghmehalsadat , Campos Rui , Ferapontova Elena E. 
Published: April 2021

AbstractIridium oxide (IrOx) is one of the most efficient electrocatalysts for water oxidation reaction (WOR). Here, WOR electrocatalysis by 1.6 nm IrOx nanoparticles (NPs) electrophoretically deposited onto spectroscopic graphite (Gr) and basal plane highly ordered pyrolytic graphite (HOPG) was studied as a function of NPs’ capping ligands and electrodeposition substrate. On Gr, OH−‐ and H2O‐capped NPs exhibited close sub‐monolayer surface coverages and specific electrocatalytic activity of 18.9‐23.5 mA nmol−1 of IrIV/V sites, at 1 V and pH 7. On HOPG, OH−‐capped NPs produced films with a diminished WOR activity of 5.17±2.40 mA nmol−1. Electro‐wettability‐induced changes impeded electrophoretic deposition of H2O‐capped NPs on HOPG, WOR currents being 25‐fold lower than observed for OH−‐capped ones. The electrocatalysis efficiency correlated with hydrophilic properties of the substrate electrodes, affecting morphological and as a result catalytic properties of the formed IrOx films. These results, important both for studied and related carbon nanomaterials systems, allow fine‐tuning of electrocatalysis by a proper choice of the substrate electrode.
Strategies for Fabricating High‐Performance Electrochemical Energy‐Storage Devices by MXenes
Authors: Yu LePing , Lu Lu , Zhou XiaoHong , Xu Lyu , Alhalili Zahrah , Wang FengJun 
Published: April 2021

AbstractSince 2011, MXenes, a family of two‐dimensional transition‐metal carbides, nitrides, and carbonitrides, have been investigated as electrodes, additives, separators, and hosts for energy‐storage devices (ESDs, including supercapacitors and metal‐ion batteries) due to their unique properties. This report focuses on the present technical issues in the field of energy storage and the corresponding solutions involving MXenes. It begins with a series of synthesis approaches (including top‐down and bottom‐up strategies) with a brief description of the structural properties, covering crystal lattice, structural defects, and surface chemistries. In addition, the impact of surface functional groups, composition of transition metals temperature and external pressure on the electrical properties of MXenes is discussed. Then, current issues of ESDs are listed with several MXene‐based solutions, including intercalation, modification of the terminating groups, chemical doping, vacancy engineering and the design of nanocomposites. Finally, the challenges in MXene‐based ESDs are summarised with some potential research directions in the future.
The Most Active Oxidase‐Mimicking Mn2O3 Nanozyme for Biosensor Signal Generation
Authors: Chen Zi‐Jian , Huang Zhicheng , Sun Yuan‐Ming , Xu Zhen‐Lin , Liu Juewen 
Published: April 2021

AbstractOxidase‐mimicking nanozymes are more desirable than peroxidase‐mimicking ones since H2O2 can be omitted. However, only a few nanomaterials are known for oxidase‐like activities. In this work, we compared the activity of Mn2O3, Mn3O4 and MnO2 and found that Mn2O3 had the highest oxidase activity. Interestingly, the activity of Mn2O3 was even inhibited by H2O2. The oxidase‐like activity of Mn2O3 was not much affected by the presence of proteins such as bovine serum albumin (BSA), but the physisorption of antibodies to Mn2O3 was not strong enough to withstand the displacement by BSA. We then treated Mn2O3 with 3‐aminopropyltriethoxysilane to graft an amine group, which was used to conjugate antibodies using glutaraldehyde as a crosslinker. A one‐step indirect competitive ELISA (icELISA) was developed for the detection of isocarbophos, and an IC50 of 261.7 ng/mL was obtained, comparable with the results of the standard two‐step assay using horseradish peroxidase (HRP)‐labeled antibodies. This assay has the advantage of significant timesaving for rapid detection of large amounts of samples. This work has discovered a highly efficient oxidase‐mimicking nanozyme useful for various nano‐ and analytical applications.
Using Small Molecules to Enhance P450 OleT Enzyme Activity in Situ
Authors: Zhang Libo , Ma Dumei , Yin Yingwu , Wang Qian 
Published: April 2021

AbstractCytochrome P450 OleT is a fatty acid decarboxylase that catalyzes the production of olefins with biofuel and synthetic applications. However, the relatively sluggish catalytic efficiency of the enzyme limits its applications. Here, we report the application of a novel class of benzene containing small molecules to improve the OleT activity. The UV‐Vis spectroscopy study and molecular docking results confirmed the high proximity of the small molecules to the heme group of OleT. Up to 6‐fold increase of product yield has been achieved in the small molecule‐modulated enzymatic reactions. Our work thus sheds the light to the application of small molecules to increase the OleT catalytic efficiency, which could be potentially used for future olefin productions.
Multifunctional Heterometallic IrIII−AuI Probes as Promising Anticancer and Antiangiogenic Agents
Authors: Redrado Marta , Benedi Andrea , Marzo Isabel , García‐Otín Angel L. , Fernández‐Moreira Vanesa , Concepción Gimeno M. 
Published: April 2021

AbstractA new class of emissive cyclometallated IrIII−AuI complexes with a bis(diphenylphosphino) methanide bridging ligand was successfully synthesised from the diphosphino complex [Ir(N^C)2(dppm)]+ (1). The different gold ancillary ligand, a triphenylphosphine (2), a chloride (3) or a thiocytosine (4) did not reveal any significant effect on the photophysical properties, which are mainly due to metal‐to‐ligand charge‐transfer (3MLCT) transitions based on IrIII. However, the AuI fragment, along with the ancillary ligand, seemed crucial for the bioactivity in A549 lung carcinoma cells versus endothelial cells. Both cell types display variable sensitivities to the complexes (IC50=0.6–3.5 μM). The apoptotic pathway is activated in all cases, and paraptotic cell death seems to take place at initial stages in A549 cells. Species 2–4 showed at least dual lysosomal and mitochondrial biodistribution in A549 cells, with an initial lysosomal localisation and a possible trafficking process between both organelles with time. The bimetallic IrIII−AuI complexes disrupted the mitochondrial transmembrane potential in A549 cells and increased reactive oxygen species (ROS) generation and thioredoxin reductase (TrxR) inhibition in comparison with that displayed by the monometallic complex 1. Angiogenic activity assays performed in endothelial cells revealed the promising antimetastatic potential of 1, 2 and 4.
Fulvalene‐Based Polycyclic Aromatic Hydrocarbon Ladder‐Type Structures: Synthesis and Properties
Authors: Bliksted Roug Pedersen Viktor , Granhøj Jeppe , Erbs Hillers‐Bendtsen Andreas , Kadziola Anders , Mikkelsen Kurt V. , Brøndsted Nielsen Mogens 
Published: April 2021

AbstractPolycyclic aromatic hydrocarbons (PAHs) have found strong interest for their electronic properties and as model systems for graphene. While PAHs have been studied intensively as single units, here PAHs were constructed in ladder‐type arrangements using cross‐conjugated fulvalene and dithiafulvalene motifs as connecting units and moving forward a convenient synthetic approach for dimerizing (thio)ketones into olefins by the action of Lawesson's reagent. Some of the PAHs can also be regarded as “super‐extended” tetrathiafulvalenes (TTFs) with some of the largest cores ever explored, being multi‐redox systems that exhibit both reversible oxidations and reductions. Concomitant absorption redshifts were observed when expanding the ladder‐type structures from one to two to three indenofluorene units, and optical and electrochemical HOMO‐LUMO gaps were found to correlate linearly. Various conformations (and solid‐state packing arrangements) were studied by X‐ray crystallography and computations.
High‐pressure Nucleation of Low‐Density Polymorphs
Authors: Sobczak Szymon , Ratajczyk Paulina , Katrusiak Andrzej 
Published: April 2021

AbstractInvited for the cover of this issue is the group of Andrzej Katrusiak at Adam Mickiewicz University. The image depicts a wave and the sun, which represent the high energy required for the high‐entropy nucleation reported in this work. Read the full text of the article at 10.1002/chem.202005121.
Nonplanar Perylene Monoimide‐Based Fluorescent Film for Enhanced BTX Sensing
Authors: Zhang Meiling , Ding Nannan , Lai Fayan , Shang Congdi , Miao Rong , Liu Zhongshan , Fang Yu 
Published: April 2021

Main observation and conclusionFilm‐based fluorescent sensors have been adapted into portable devices for the vapor phase detection. The satisfactory sensing performance (e.g., sensitivity, selectivity, reusability) largely benefits from fluorophores. Here we report a new nonplanar perylene monoimide derivative (PMI‐CB) and demonstrate its application in a miniaturized film‐based fluorescent sensor for BTX (i.e., benzene, toluene, xylene) detection. The fluorophore of PMI‐CB is obtained through incorporating a three‐dimensional o‐carborane with the perylene monoimide (PMI). Compared to a planar PMI derivative (PMIA), the nonplanar PMI‐CB with reduced intermolecular aggregation exhibits enhanced fluorescence intensities in both solvents and film state. The PMI‐CB film exhibited fluorescence enhancements for BTX, while fluorescence quenching for commonly interfering compounds like ethanol, triethylamine, and acetone. Such opposite response behavior endows the PMI‐CB‐based sensor with the ability for selective detection of BTX. Importantly, our PMI‐CB film is not sensitive to water. The sensitivity test shows that the PMI‐CB film can detect benzene vapor at a concentration of as low as 3.3 mg/m3 without any preconcentration procedures, and exhibits a good linear relationship from 3.3 to 425.9 mg/m3. On the basis of this work, a portable detector with high selectivity, sensitivity, reusability, and low power consumption can be adapted for the on‐site BTX detection.
Harpagide Inhibits Microglial Activation and Protects Dopaminergic Neurons as Revealed by Nanoelectrode Amperometry†
Authors: Zhang Fu‐Li , Tang Yun , Jiang Hong , Yang Xiao‐Ke , Huang Wei‐Hua 
Published: April 2021

Main observation and conclusionParkinson's disease (PD) is one of the most common neurogenerative diseases (NDDs), characterized as less neurotransmitter release and loss of dopaminergic (DAergic) neurons with microglial inflammatory response as a key player. Natural product harpagide with anti‐inflammatory function is a potential therapeutic drug of PD, but its role towards microglial activation and inflammation‐mediated neuronal injury remained unsure. In this work, taking advantage of nanoelectrode amperometry with high temporal‐spatial resolution, we used nanowire electrodes (NWEs) to monitor intracellular reactive oxygen species (ROS) level and carbon fiber nanoelectrodes (CFNEs) to detect synaptic dopamine exocytosis, to explore the effect of harpagide in modulating microglial inflammatory reaction and protecting DAergic neurons in neuron‐microglia co‐culture system. The results indicate that harpagide inhibits microglia from activation induced by LPS/IFN‐γ and generation of ROS, therefore reduces inflammation‐mediated neural injury and maintains dopamine exocytosis function. These conclusions establish that harpagide possesses promising avenues for preventive or therapeutic interventions against PD and other NDDs.
A Hypervalent Cyclic Dibenzoiodolium Salt as a Halogen‐Bond‐Donor Catalyst for the [4+2] Cycloaddition of 2‐Alkenylindoles
Authors: Nishida Yuki , Suzuki Takumi , Takagi Yuri , Amma Emi , Tajima Ryoya , Kuwano Satoru , Arai Takayoshi 
Published: April 2021

AbstractA stable, hypervalent cyclic dibenzoiodolium salt acted as a strong halogen bonding (XB)‐donor catalyst for [4+2] cycloaddition of 2‐alkenylindoles, and not as an oxidizing agent. The cross‐[4+2] cycloaddition of 2‐vinylindoles with 2‐alkenylindoles was catalyzed smoothly by the hypervalent cyclic dibenzoiodolium triflate catalyst to give the tetrahydrocarbazoles in up to 99 % yield with 17 : 1 diastereoselectivity. The hypervalent cyclic dibenzoiodolium salt was also applicable to the Povarov reaction of 2‐vinylindole with N‐p‐methoxyphenyl (PMP) imine to give the indolyl‐tetrahydroquinoline in 83 % yield.
Data denoising and compression of intelligent transportation system based on two‐dimensional discrete wavelet transform
Authors: Dou Huili , Wang Guohua 
Published: April 2021

SummaryTwo‐dimensional discrete wavelet transform is an important tool for digital image analysis. It is widely used in the field of image editing, such as image coding and compression and digital image processing. The realization of effective two‐dimensional discrete wavelet transform has important realities in data or image processing. This paper mainly introduces the research of intelligent transportation system data denoising and compression based on two‐dimensional discrete wavelet transform and intends to provide solutions to the problem of data overload in the process of intelligent transportation system data collection, transmission, and storage. This paper proposes the construction of two‐dimensional discrete wavelet transform, including separation calculation method and non‐separation calculation method, and proposes the construction of time–space data model of intelligent transportation system, including support vector machine (SVM), K nearest neighbor algorithm, and deep neural network algorithm. It is proposed to construct two‐dimensional wavelet transform to denoise and compress data of intelligent transportation systems. The experimental results in this paper show that the signal after denoising by two‐dimensional discrete wavelet transform is smoother, with a maximum difference of 0.57, and the denoising effect is better.
The causal association between body mass index and type 2 diabetes mellitus—evidence based on regression discontinuity design
Authors: Guo Zhaoyan , Liu Li , Yu Fangfang , Cai Yaning , Wang Junyi , Gao Yang , Ping Zhiguang 
Published: April 2021

AbstractObjectiveThis study aimed to investigate and determine the precise causal association between body mass index (BMI) and type 2 diabetes mellitus (T2DM) using a regression discontinuity design (RDD).MethodsThe cross‐sectional data of 8550 participants were from the China Health and Nutrition Survey (CHNS) in 2015. Influencing factors with statistically significant were selected with logistic regression analysis, and a risk prediction model was established to obtain the risk of individuals suffering from T2DM. RDD was performed with BMI as the grouping variable and the risk of individuals suffering from T2DM as the outcome variable.ResultsThe predictive factors in the T2DM risk prediction model were age, gender, BMI, habitation, education, physical activity level, preference for sugary beverages, walking, self‐evaluation health status and history of hypertension. The AUC (area under receiver operating characteristic curve) of the T2DM risk prediction model was 0.849 (95% CI: 0.833, 0.866). BMI was an independent risk factor for T2DM (OR = 1.109, p < 0.001); at BMI = 31 kg/m2, the risk of T2DM increased sharply by 5.03% (p = 0.006).ConclusionsThere was a positive causal association between BMI and T2DM; when BMI = 31 kg/m2, the risk of individuals suffering from T2DM was sharply increased.
Optimal DCFP bearing properties and seismic performance assessment in nondimensional form for isolated bridges
Authors: Castaldo Paolo , Amendola Guglielmo 
Published: April 2021

AbstractThe study analyzes the influence of double concave friction pendulum (DCFP) isolator properties on the seismic performance of isolated multispan continuous deck bridges. The behavior of these systems is analyzed by employing an eight‐degree‐of‐freedom model accounting for the pier flexibility in addition to the rigid presence of both abutment and deck, whereas the DCFP isolator behavior is described combining two single FP devices in series. The uncertainty in the seismic input is taken into account by considering a set of nonfrequent natural records with different characteristics. The variation of the statistics of the response parameters relevant to the seismic performance of the isolated bridges is investigated through the proposal of a nondimensionalization of the motion equations, with respect to the seismic intensity, within an extensive parametric study carried out for different isolator and bridge properties. Moreover, two cases related to different ratios between the sliding friction coefficients of the two surfaces of the DCFP devices are analyzed with the aim also to evaluate the corresponding optimal values able to minimize the seismic demand to the pier. In this way, all the presented nondimensional results are useful for the preliminary design or retrofit of multispan continuous deck bridges, isolated with DCFP devices, located in any site and in relation, especially, to the seismic ultimate limit states.