bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efek Penambahan Vitamin C terhadap Aktivitas Klindamisin dalam Menghambat Pertumbuhan Streptococcus pneumoniae secara In Vitro
Authors: Kurniawan Bagus Dwi , Agustina Dini , Efendi Erfan 
Published: June 2021

Pneumonia is one of the lower respiratory tract infection involving respiratory bronchioles and alveoli that mostly caused by Streptococcus pneumoniae.Clindamycin is one of the drug of choice for pneumoniae. This drugs inhibits the growth of S. pneumoniae by producing ROS (Reactive Oxygen Species). Recent study has shown that vitamin C could generate ROS leading to DNA-damage on bacteria. The aims of this study was to know the possible benefit effect of adding vitamin C towards clindamycin inhibition activity against the growth of S. pneumoniae in vitro. This research was conducted by using 7 groups which consist of negative control (aquades), positive control (clindamycin), and test group 1 until 5 that given the combination of clindamycin and vitamin C as follows 2,5 mg/ml; 5 mg/ml; 10 mg/ml; 20 mg/ml; and 40 mg/ml. The inhibition effect of growing S. pneumoniae shown by the inhibition zone diameter. The average of inhibition zone on negative control, positive control, and test group were 5; 24,12; 24,62; 26,08; 27,58; 28,74; and 29,76 mm. These result show a significant correlation based on Pearson test (the coefficient correlation’s result is +0,910). The logarithmic regression revealed the minimal concentration of vitamin C was 1,767 mg/ml. It can be concluded that vitamin C increased the activity of clindamycin by inhibiting the growth of S.pneumoniae in vitro.
Keywords: Streptococcus pneumoniae, ROS, Clindamycin, Vitamin C
Pengaruh Terapi Emotional Freedom Technique (EFT) terhadap Depresi pada Klien Hipertensi
Authors: Sahlia Mila Yuni , Wantiyah Wantiyah , Hakam Mulia 
Published: June 2021

Hypertension is a disease that characterized by increased of systolic and diastolic bloodpressure that can cause problems in both physical and psychological problems. One ofpsychological problems is depression. EFT therapy is a relaxation technique that could beused to decrease depression in hypertension client. The purpose of this study was to analyzethe effect of EFT therapy on depression in hypertension client. This research usedquasi experimental method with control group pretest-posttest design. The sampling techniquewas consecutive sampling involving 20 respondents that divided into 10 respondentas intervention group who got EFT therapy and 10 respondents as control group who doneactivity daily. Data were analyzed by using Wilcoxon and Mann Whitney U Test with 95%CI (ɑ=0,05). The result showed that there was a difference of depression before given EFTin intervention group (p=0,003), while in control group there was no difference (p=1,000).There was significant difference of depression on client hypertension in both interventionand control group (p=0,001).The relaxation effect of EFT therapy stimulates the pituitarygland to release endorphin hormone to produce serotonin hormone and dopamine hormone.The conclusion is EFT therapy can reduce depression in hypertension clients, thereforeit can be applied as one of the non-pharmacological therapy in hypertension client.
Keywords: EFT Therapy, Depression, Hypertension
The Socio-economic Role of Medieval Parisian Colleges Through the ‘Studium Parisiense’ Database
Authors: Genet Jean-Philippe , Kouamé Thierry , Lamassé Stéphane 
Published: June 2021

Studium Parisiense es una base de datos cuyo objetivo es el de identificar a todos los estudiantes y maestros de la Universidad de París. Aún por concluir, cuenta hoy con 20000 fichas. En base a estos datos, se ha intentado medir el impacto del sistema de colegios mayores en el París medieval. El resultado logrado apunta a una tendencia cronológica: el desarrollo del sistema de colegios mayores en el siglo XIV resulta ser una solución más eficaz para acoger a la creciente población académica que la creación de casas de canónigos agustinos (siglo XII) y la de conventos mendicantes (siglo XIII). Por otro lado, tanto en términos de reclutamiento internacional como de producción literaria, salvo la excepción de la Sorbona, los colegios mayores parisinos no dejaban de ser instituciones de segundo nivel. Sin embargo, estas instituciones, situadas en la ribera izquierda del Sena, proporcionaron mejores condiciones de estudio a la población estudiantil y ayudaron a disciplinarla. A finales del siglo XV, los colegios mayores parisinos lograron mejorar su reputación y atraer de nuevo estudiantes europeos.
Elisabetta Canobbio. Lauree pavesi nella prima metà del ‘500, II (1513- 1535)
Authors: Ramis Barceló Rafael 
Published: June 2021

Este artículo reseña: Elisabetta Canobbio. Lauree pavesi nella prima metà del ‘500, II (1513- 1535). Milano: Cisalpino, 2020. 613 pp.
Effects of an equol-containing supplement on advanced glycation end products, visceral fat and climacteric symptoms in postmenopausal women: A randomized controlled trial
Authors: Yoshikata Remi , Myint Khin Zay Yar , Ohta Hiroaki , Ishigaki Yoko 
Published: June 2021

Abstract
Introduction: Equol, an isoflavone derivative whose chemical structure is similar to estrogen, is considered a potentially effective agent for relieving climacteric symptoms, for the prevention of lifestyle-related diseases, and for aging care in postmenopausal women. We investigated the effect of an equol-containing supplement on metabolism and aging and climacteric symptoms with respect to internally produced equol in postmenopausal women.Methods: A single-center, randomized controlled trial (registration number: UMIN000030975) on 57 postmenopausal Japanese women (mean age: 56±5.37 years) was conducted. Twenty-seven women received the equol supplement, while the remaining received control. Metabolic and aging-related biomarkers were compared before and after the 3-month intervention. Climacteric symptoms were assessed every month using a validated self-administered questionnaire in Japanese postmenopausal women.Results: Three months postintervention, the treatment group showed significant improvement in climacteric symptoms compared to the control group (81% vs. 53%, respectively, p=0.045). We did not observe any beneficial effect on metabolic and aging-related biomarkers in the intervention group. However, in certain populations, significant improvement in skin autofluorescence, which is a measurement of AGE skin products, and visceral fat area was observed, especially among equol producers.Conclusion: Women receiving equol supplementation showed improved climacteric symptoms. This study offered a new hypothesis that there may be a synergy between supplemented equol and endogenously produced equol to improve skin aging and visceral fat in certain populations.
Hydrogen Production from Biogas: Methods and Economic Analysis
Authors: Kumar Ravindra , Kumar Anil , Pal Amit 
Published: June 2021

Abstract
In present days, H2 is mainly produced via natural gas from thermochemical methods. The importance of renewable H2 production has increased due to energy issues, global environmental, fossil fuel depletion, and pure hydrogen demand. Biogas is produced from anaerobic digestion or carbon-based waste fermentation methods. It might be a substitute resource to the creation of hydrogen. Methane (CH4) and carbon dioxide (CO2) are two significant constituents of biogas, and these are multipurpose feedstock materials for the generation of valuable chemicals and fuels. This paper presents major hydrogen generation techniques from biogas reforming in detail and a short discussion of biogas reforming's economic analysis. The effective operating parameters such as reaction temperature, gas hourly space velocity and O2/CH4 ratio are also discussed. Biogas has more potential; however, it needs more research on some issues such as deactivation of the catalyst, purification of biogas and removable of H2S. Various reforming methods can be nominated for H2 production depend on biogas composition, the need for hydrogen purity, investment availability and quantity of the desired hydrogen.
Comparison and toxicity assessment of co-composting process by pistachio wastes and date-palm straw combined with municipal sewage sludge
Authors: Parizi Habibe Jafariniya , Mokhtari Mehdi , Eslami Hadi , Madadizadeh Farzan , Jalili Mahrokh , Mobini Mohammad , Hosseini Abdolreza Nassab , Ebrahimi Ali Asghar 
Published: June 2021

Abstract
This study aimed to toxicity evaluate and compare the new co-composting process of pistachio dehulling waste combined with municipal sewage sludge (PW + SS) and date-palm straw combined with municipal sewage sludge (PS + SS). The process was evaluated over a 60-day period. During the process, physicochemical parameters (temperature, humidity, pH, electrical conductivity (EC), carbon to nitrogen ratio (C/N), ash and organic carbon (OC)), microbial indicators (parasite eggs, salmonella, E. coli), heavy metals (copper, zinc, Iron, manganese, lead, cadmium, nickel), and germination index were measured. The results showed that in the PW + SS reactor the maximum temperature reached 59°C on the 32th day and in the PS + SS reactor reached 39°C on 18th day. The pH level in PW + SS reached a minimum of 3.2 on the 14th day and then increased and finally reached a maximum of 9.5. The pH level in PS + SS had an increasing trend and finally reached 7.1. Ash percentage had an increasing trend in PW + SS and finally reached 27.5 and reached 19.1 in PS + SS (p = 0.038). EC, C/N and OC in both reactors had a significant decreasing trend. E. coli microbial indicator in both reactors decreased from ≥ 105 to zero at the end of the process. The amounts of heavy metals in both reactors had an increasing trend and were within the standard range. Toxicity assessment showed that the PS + SS compost was 100% in all concentrations and the PW + SS compost reached 100% by dilution; therefore, the product of PS + SS was less toxic than the product of PW + SS.
Technological Innovation and Green Growth: Evidence from South Asia
Authors: nosheen misbah , Shah Kashif Raza , Hasan Anam 
Published: June 2021

Abstract
Green growth means promote economic development and growth, while certify that natural assets continue to provide the resources and ecological. This research analyzes that how green growth is affected by technological innovation for South Asia (Bangladesh, Pakistan, India, Sri Lanka, and Nepal) economies during 1990 to 2019. Basic econometric tests such as Cross-section dependence test, Panel unit root tests and Wester Lund co-integration test is applied. Furthermore, we use the FMOLS and DOLS models for estimating the impact of CO2 emissions on patent by resident, renewable energy consumption, foreign direct investment, and GDP per capita. The results of all panel unit root tests reveal that all the variables are stationary at a 1st difference. Westerlund panel co-integration test confirmed the long-run relationship. In both the FMOLS and DOLS models, the findings show that patent application by residents and renewable energy consumption have negative and statistically significant impacts on CO2 emissions. While GDP has positive and statistically significant effect on CO2 emissions and FDI has no effect on CO2 emissions in both the long run and short run. The results recommend that government needs to take sustainable energy related source, for instance, renewable energy consumption which are beneficial to ecosystem as it increases green economy.
Tear Osmolarity Changes Following External and Trans-Canalicular Dacryocystorhinostomy in Primary Acquired Nasolacrimal Duct Obstruction
Authors: Gurez Ceren , Nacaroğlu Şenay Aşık , Yılmaz Ahu 
Published: June 2021

Abstract
Purpose: The aim of this study is to evaluate the tear osmolarity(TO) in patients with epiphora caused by primary acquired nasolacrimal-duct obstructions(PANDOs), before and one month after an external dacryocystorhinostomy(E-DCR) and trans-canalicular laser-assisted endoscopic dacryocystorhinostomy(TLA-DCR).Material-Methods: Twenty eyes of 21 patients(16 women, 5 men) who suffered from epiphora and, 20 healthy eyes of the same subjects were included in this study. External(Group 1) or laser-assisted(Group 2) DCR were applied to all patients with PANDO.Results: The mean age of the subjects was 60.09±8.46 in Group 1, 57.50±9.41 in Group 2 and, 55.13±9.38 in healthy control subjects. The mean period for complaints of epiphora was 1.9±0.7 years. Nasolacrimal duct irrigation was successful in all patients at the first-month visit after surgery. Group 1 had a mean TO of 284.16±12.43 mOsm/l and, Group 2 had 286.70±10.46 mOsm/l before DCR, and this increased to 295.75±5.86 mOsm/l and, 298.70±8.76 mOsm/l one month after DCR, respectively. Preoperative TO values in both groups were significant hypoosmolar compared with the control group (292.27±9.65 mOsm/l). No significant differences were detected between postoperative and control group TO values.Conclusion: We found no significant osmolarity changes between surgery and control groups.
Comparison the Effect of Organized education by Group discussion and film screening on Anxiety and Contrast-induced nephropathy in Coronary catheterization Patients; A Randomized Clinical Trial
Authors: Nastaran Majid , Aghebati Nahid , FalSoleiman Homa , Esmaily Habibollah , Jeddi Hossein 
Published: June 2021

Abstract
Background: Anxiety is one of the most prevalent psychological complications in patients undergoing cardiac catheterization that can be effective on the patients' understanding to do self-care to prevent some complications such as contrast induced nephropathy. The aim of this study was to compare the effect of education by group discussion with videotape on anxiety and contrast induced nephropathy of Coronary catheterization patients. Method: A randomized clinical trial was implemented with 213 patients in three groups at Javad-Al-Aemeh Hospital, Mashhad, Iran, during February to September 2018. An organized educational program was first developed based on an integrative review. The patients were randomly allocated to three groups: group discussion (n=71), film (n=73) and control (n=69) using randomized time blocks. Anxiety was assessed using Spiel Berger Inventory before and 1 hour after the education, before transferring to Cat Lab. The serum creatinine was assessed on arrival, 24 and 72 hours after the procedure. The data were analyzed using ANOVA, Tukey, repeated ANOVA, paired t test and chi square tests by SPSS16. Results: There was no significant difference in mean anxiety between groups before the intervention (P= 0.64), but the anxiety in the videotape group and group discussion decreased significantly after the intervention (p<0.001). There wasn't any significant clinical increase in serum creatinine in all three groups after 72 hours.Conclusion: Using Group discussion and film screening can be recommended to the community nurses to reduce the cardiac catheterization candidate patient's anxiety and prevent contrast-induced nephropathy.The present study was registered in the Iranian Registry of Clinical Trials with a code of IRCT2016022626776N1.Registration date in IRCT : 2017-07-23, 1396/05/01https://www.irct.ir/trial/22094
Age- and gender-dependent differences in attitudes towards COVID-19 vaccination and underlying psychological processes
Authors: Tanaka Toshiko , Nihonsugi Tsuyoshi , Ohtake Fumio , Haruno Masahiko 
Published: June 2021

Abstract
The most promising way to prevent the explosive spread of COVID-19 infection is to achieve herd immunity through vaccination. It is therefore important to motivate those who are less willing to be vaccinated. To address this issue, we conducted an online survey of 6232 Japanese people to investigate age- and gender- dependent differences in attitudes towards COVID-19 vaccination and the underlying psychological processes. We asked participants to read one of nine different messages about COVID-19 vaccination and rate their willingness to be vaccinated. We also collected their 17 social personality trait scores and demographic information. We found that males 10-20 years old showed the minimum willingness to be vaccinated. We also found that prosocial traits are the driving force for young people, but the motivation in older people also depends on risk aversion and self-interest. Furthermore, an analysis of 9 different messages demonstrated that for young people (particularly males), the message emphasizing the majority’s intention to vaccinate and scientific evidence for the safety of the vaccination had the strongest positive effect on the willingness to be vaccinated, suggesting that the herding effect arising from the “majority + scientific evidence” message nudges young people to show their prosocial nature in action.
Superhydrophobic Materials With Good Oil/Water Separation And Self-Cleaning Prepared Through A Environment-Friendly And Two-Component Method
Authors: Lin Wensheng , Cao Mengting , Olonisakin Kehinde , Li Ran , Zhang Xinxiang , Yang Wenbin 
Published: June 2021

Abstract
A novel, versatile, environment-friendly, and economical method was developed to fabricate functional superhydrophobic surfaces on various substrates, including wood, bamboo, cotton, filter paper, sponge, glass, textile, and copper. This method involves synthesizing a two-component modifier solution consisting of SiO2 nanoparticles combination with poly(methylhydrogen)siloxane (PMHS) modification. The superhydrophobicity of the coated surfaces was created by PMHS combined with SiO2 nanoparticles to construct a rough hierarchical structure on the substrate surface. As a result, all superhydrophobic surfaces were maintained under an indoor environment and relative humidity (RH) of 50% for 30 days. Furthermore, the superhydrophobic surfaces were also maintained at environmental conditions of minus 20℃ for 24 hours. It was also confirmed that these surfaces exhibited excellent self-cleaning, oil/water separation, and elimination of underwater oil properties. The method for fabricating superhydrophobic materials proposed in this study will have great application potential in preparing large-scale superhydrophobic surfaces for use in ancient building protection.
Myth And Facts About The Evolving Role of Laparoscopic Splenectomy In Isolated High Grades Splenic Injuries In Hemodynamically Stable Patients With Blunt Abdominal Trauma. Randomized Controlled Trial.
Authors: Habeeb Tamer.A. A.M. , Osman Gamal , Ibrahim Amr , Riad Mohamed , Metwalli Abd-Elrahman M. , Mansour Mohamed . I. , mohamed Ahmed S. , negm Said . M. , Wasefy Tamer , Baghdadi Muhammad . A. , Sieda Bassem , elsayed Ashraf . a. , Amin Mohamed . F. , Abdalla Wael M , Elaidy Mostafa. M. , Mawla Walid A. , Mohammad Hatem , Habib Fady Mehaney , Abdelhamid Mohamed. I. 
Published: June 2021

Abstract
Background: Spleen is the most common intra-abdominal organ injury in blunt abdominal trauma. Splenectomy (open or laparoscopic) is the role in treatment of severe injuries of spleen or after failure of conservative treatment.Aim of the work: Compare the outcomes between open versus laparoscopic in high grade splenic injuries.Methods: This study includes 70 patients with various grades of splenic injuries in abdominal trauma. The patients were 15 years and older. They were categorized into two groups: open splenectomy group (35 patients) and laparoscopic splenectomy group (35 patients). The study was performed from January, 2012 to July 2017. Variables included demographics data, splenic injury graded by computerized tomography, duration of operation (in minutes), intra-operative blood loss (in ml), and intraoperative blood transfusion, length of hospital stay (in days), complications and mortality.Results: There was no significant difference or association between groups as regard age, sex and causes of splenic injury (p=0.374, 0.41, 0.38).Most cases were under 35 years old male patients exposed to motor car accidents. As regard intraoperative data, no statistically significant difference between both groups except for blood loss and transfusion that were statistically significant to the open group (p=0.039*).In the laparoscopic group, operational time was longer than open but no statistically significant (p=0.11).as regard conversion, we found that 14% of laparoscopic group (5 cases) had conversion. Most cases operated by laparoscopic approach were in grade III, IV with no cases tried in grade V (p=0.06). No statistically significant difference between both groups as regard postoperative variables except Pain (p=0.0003), and hospital stay(p=0.00) that were significantly longer among open group.The immediate postoperative complications showed that Wound infection, Missed injuries, pancreatic fistula and ileus were significantly higher among open group (p=0.00, 0.006, 0.02, 0.0004).The delayed postoperative complications where Incisional hernia (p=0.001) and Adhesive intestinal obstruction (p=0.00) were significantly associated with open group.Conclusion: In high-grade splenic injuries patients, this study found that laparoscopic splenectomy is safe.
Specific Serodiagnosis of Animal Brucellosis Based on A Recombinant Multiepitope Protein Antigen
Authors: Xu Linlin , Bai Qiongqiong , Zhang Jinpeng , Jiao Yang , Yin Dehui 
Published: June 2021

Abstract
Background: Brucellosis is a zoonotic infectious disease that causes substantial public health problems and endangers the development of animal husbandry in endemic areas, causing huge losses of personal property. Early diagnosis of sick animals is a crucial step in reducing the incidence of brucellosis.Objective: In this study, we designed a recombinant multiepitope protein (rMEP) as a serum diagnostic antigen for brucellosis and evaluated its diagnostic value in cattle and goats.Methods: An indirect enzyme-linked immunosorbent assay (iELISA) was used to assess the new rMEP, and 159 goat and 153 bovine serum samples were measured, including brucellosis and nonbrucellosis samples. To better observe the effectiveness of rMEP, we performed receiver operating characteristic (ROC) curve analysis.Results: Evaluation of the 159 goat serum samples showed that the area under the ROC curve (AUC) was 0.9976, and compared with serum tube agglutination test (SAT) and the Rose Bengal plate agglutination test (RBPT), the positive and negative diagnostic accuracies of ELISA were 98.92% (92/93) and 96.97% (64/66), respectively. Evaluation of the 153 bovine serum samples showed that the AUC was 0.9974, and compared with those of SAT and RBPT, the positive and negative diagnostic accuracies of ELISA were 98.65% (73/74) and 96.20% (76/79), respectively.Conclusion: The results indicated that rMEP, as a protein antigen, can be used to diagnose brucellosis with high accuracy in both goats and bovines.
The Study on Angiotensin II Induced-Ferroptosis in Vascular Endothelial Cells
Authors: fang hong , liu Chi , Cavdar Omer , Shen Yi 
Published: June 2021

Abstract
PurposeTo verify the effect of Angiotensin II on ferroptosis in vascular endothelial cells and clarify the related mechanism. MethodsHUVECs were evaluated for p53, P21,ALOX12, VEGF, MDA,GSH. Molecular marker impact upon AngII-induced ferroptosis was evaluated with students’ t-test，one-way analysis of variance (ANOVA).ResultsAs the concentration of Ang II increased，the level of ALOX12, P53,GSH and MDA increased in HUVECs. The expression of VEGFA in HUVECs is negatively correlated with dose of Ang II. Incubation of HUVECs in AngII and valsartan for 48hr reduces ALOX12, P21, GSH and MDA. Compared with the single AngII group, ALOX12, P21, GSH and MDA in valsartan group was decreased significantly（p=0.000）.In pifithrin-α hydrobromide-treated, ALOX12, P21, GSH and MDA was reduced significantly, as compared to valsartan group（p=0.000）. The most larger reduction in ALOX12, P21,GSH and MDA was pifithrin - α hydrobromide combined with valsartan group. In contrast, the expression of VEGFA increased significantly after HUVECs were treated with pifithrin - α hydrobromide and valsartan（p=0.000）.ConclusionsAngII can induce ferroptosis of vascular endothelial cells in a dose-dependent manner. The mechanism of AngII-induced ferroptosis may be regulated through the signal axis of ATR1,2-p53-ALOX12.