bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two-Year Change in Blood Pressure Status and Left Ventricular Mass Index in Chinese Children
Authors: Li Zilin , Duan Yao , Zhao Min , Magnussen Costan G. , Xi Bo 
Published: August 2021

Background: Elevated blood pressure (BP) is associated with target organ damage, such as left ventricular hypertrophy (LVH), in childhood. However, it is unclear if children who resolve elevated BP have reduced levels of left ventricular mass index (LVMI). This study aimed to examine the association between change in BP status over 2 years and LVMI among Chinese children.Methods: Data were from 1,183 children aged 6–11 years at baseline in 2017 who were followed up in 2019 in the Huantai Childhood Cardiovascular Health Cohort Study. Change in BP status over 2 years from baseline to follow-up was categorized as: persistent normal BP, resolved elevated BP (elevated BP at baseline, normal BP at follow-up), incident elevated BP (normal BP at baseline, elevated BP at follow-up), and persistent elevated BP. Elevated BP status was defined according to national reference standards as systolic or diastolic BP levels ≥ sex-, age-, and height-specific 95th percentiles.Results: LVMI levels were lowest in children with persistent normal BP (30.13 g/m2.7), higher in those with incident elevated BP (31.27 g/m2.7), and highest in those with persistent elevated BP (33.26 g/m2.7). However, LVMI levels in those who had resolved elevated BP (30.67 g/m2.7) were similar to those with persistent normal BP. In the fully adjusted model, compared with children with persistent normal BP, those with persistent elevated BP and incident elevated BP had higher LVMI at follow-up (ß = 3.131, p &lt; 0.001; ß = 1.143, p = 0.041, respectively). In contrast, those who had resolved elevated BP did not have a significantly higher LVMI (ß = 0.545, p = 0.194) than those with persistent normal BP.Conclusion: Developing or maintaining elevated BP over a 2-year period in childhood associated with higher levels of LVMI, but those able to resolve their elevated BP status over the same period had LVMI levels that were similar with those who had normal BP at both time points. Thus, it is important to identify children with elevated BP at early time and to take effective measures to lower their BP levels, thereby reducing high LVMI levels and related cardiovascular diseases in the future.
SMPDL3B Predicts Poor Prognosis and Contributes to Development of Acute Myeloid Leukemia
Authors: Qu Huiqing , Zhu Ye 
Published: August 2021

Background: Acute myeloid leukemia (AML), characterized by the low cure rate and high relapse, urgently needs novel diagnostic or prognostic biomarkers and potential therapeutic targets. Sphingomyelin Phosphodiesterase Acid Like 3B (SMPDL3B) is a negative regulator of Toll-like receptor signaling that plays important roles in the interface of membrane biology and innate immunity. However, the potential role of SMPDL3B in human cancer, especially in AML, is still unknown.Methods: The expression of SMPDL3B in AML samples was investigated through data collected from Gene Expression Omnibus (GEO). Association between SMPDL3B expression and clinicopathologic characteristics was analyzed with the chi-square test. Survival curves were calculated by the Kaplan–Meier method. Cox univariate and multivariate analyses were used to detect risk factors for overall survival. The biological functions of SMPDL3B in human AML were investigated both in vitro and in vivo.Results: Expression of SMPDL3B mRNA was significantly upregulated in human AML samples and closely correlated to cytogenetics risk and karyotypes. Elevated expression of SMPDL3B was associated with poor overall survival and emerged as an independent predictor for poor overall survival in human AML. Blocked SMPDL3B expression inhibited AML cells growth both in vitro and in vivo via promoting cell apoptosis.Conclusion: Taken together, our results demonstrate that SMPDL3B could be used as an efficient prognostic biomarker and represent a potential therapeutic target for human AML.
Replacing Manual Planning of Whole Breast Irradiation With Knowledge-Based Automatic Optimization by Virtual Tangential-Fields Arc Therapy
Authors: Castriconi Roberta , Esposito Pier Giorgio , Tudda Alessia , Mangili Paola , Broggi Sara , Fodor Andrei , Deantoni Chiara L. , Longobardi Barbara , Pasetti Marcella , Perna Lucia , del Vecchio Antonella , Di Muzio Nadia Gisella , Fiorino Claudio 
Published: August 2021

PurposeTo implement Knowledge Based (KB) automatic planning for right and left-sided whole breast treatment through a new volumetric technique (ViTAT, Virtual Tangential-fields Arc Therapy) mimicking conventional tangential fields (TF) irradiation.Materials and MethodA total of 193 clinical plans delivering TF with wedged or field-in-field beams were selected to train two KB-models for right(R) and left(L) sided breast cancer patients using the RapidPlan (RP) tool implemented in the Varian Eclipse system. Then, a template for ViTAT optimization, incorporating individual KB-optimized constraints, was interactively fine-tuned. ViTAT plans consisted of four arcs (6 MV) with start/stop angles consistent with the TF geometry variability within our population; the delivery was completely blocked along the arcs, apart from the first and last 20° of rotation for each arc. Optimized fine-tuned KB templates for automatic plan optimization were generated. Validation tests were performed on 60 new patients equally divided in R and L breast treatment: KB automatic ViTAT-plans (KB-ViTAT) were compared against the original TF plans in terms of OARs/PTVs dose-volume parameters. Wilcoxon-tests were used to assess the statistically significant differences.ResultsKB models were successfully generated for both L and R sides. Overall, 1(3%) and 7(23%) out of 30 automatic KB-ViTAT plans were unacceptable compared to TF for R and L side, respectively. After the manual refinement of the start/stop angles, KB-ViTAT plans well fitted TF-performances for these patients as well. PTV coverage was comparable, while PTV D1% was improved with KB-ViTAT by R:0.4/L:0.2 Gy (p &lt; 0.05); ipsilateral OARs Dmean were similar with a slight (i.e., few % volume) improvement/worsening in the 15–35 Gy/2–15 Gy range, respectively. KB-ViTAT better spared contralateral OARs: Dmean of contralateral OARs was 0.1 Gy lower (p &lt; 0.05); integral dose was R:5%/L:8% lower (p &lt; 0.05) than TF. The overall time for the automatic plan optimization and final dose calculation was 12 ± 2 minutes.ConclusionsFully automatic KB-optimization of ViTAT can efficiently replace manually optimized TF planning for whole breast irradiation. This approach was clinically implemented in our institute and may be suggested as a large-scale strategy for efficiently replacing manual planning with large sparing of time, elimination of inter-planner variability and of, seldomly occurring, sub-optimal manual plans.
Meta-Analysis for the Prediction of Mortality Rates in a Pediatric Intensive Care Unit Using Different Scores: PRISM-III/IV, PIM-3, and PELOD-2
Authors: Shen Yaping , Jiang Juan 
Published: August 2021

Introduction:The risk of mortality is higher in pediatric intensive care units (PICU). To prevent mortality in critically ill infants, optimal clinical management and risk stratification are required.Aims and Objectives:To assess the accuracy of PELOD-2, PIM-3, and PRISM-III/IV scores to predict outcomes in pediatric patients.Results:A total of 29 studies were included for quantitative synthesis in meta-analysis. PRISM-III/IV scoring showed pooled sensitivity of 0.78; 95% CI: 0.72–0.83 and pooled specificity of 0.75; 95% CI: 0.68–0.81 with 84% discrimination performance (SROC 0.84, 95% CI: 0.80–0.87). In the case of PIM-3, pooled sensivity 0.75; 95% CI 0.71–0.79 and pooled specificity 0.76; 95% CI 0.73–0.79 were observed with good discrimination power (SROC, 0.82, 95% CI 0.78–0.85). PELOD-2 scoring system had pooled sensitivity of 0.78 (95% CI: 0.71–0.83) and combined specificity of 0.75 (95% CI: 0.68–0.81), as well as good discriminating ability (SROC 0.83, 95% CI: 0.80–0.86) for mortality prediction in PICU patients.Conclusion:PRISM-III/IV, PIM-3, and PELOD-2 had good performance for mortality prediction in PICU but with low to moderate certainty of evidence. More well-designed studies are needed for the validation of the study results.
The Influence of Perioperative Antibiotic Prophylaxis on Wound Infection and on the Colonization of Wound Drains in Patients After Correction of Craniosynostosis
Authors: Holle Johannes , Finger Tobias , Lugonja Julia , Schmidt Florian , Schaumann Andreas , Gratopp Alexander , Thomale Ulrich-Wilhelm , von Bernuth Horst , Schulz Matthias 
Published: August 2021

Objective: Evidence for the duration of perioperative antibiotic prophylaxis (PAP) after the correction of craniosynostosis in children is scarce. We evaluated the necessary duration of PAP to ensure a minimal rate of postoperative wound infections.Methods: In this monocentric, retrospective, and prospective pilot study, two PAP protocols were compared. From August 2017 to May 2018, treatment group 1 (TG 1) was treated using the standard PAP protocol with at least three doses of antibiotics. Between May 2018 and March 2019, a shortened PAP with a single-shot administration was given to treatment group 2 (TG 2a and b). Endpoints of this study were wound infection rate, colonization rate of wound drains, and the course of treatment reflected by clinical and laboratory data.Results: A cohort of 187 children underwent craniosynostosis correction: 167 were treated according to protocols-−95 patients with at least three doses (TG 1) and 72 patients with a single-shot of cefuroxime (TG 2a). Baseline characteristics were similar for both groups. We could not detect significant differences, neither for wound infection rates (TG 1: 1.1%, TG 2a: 0.0%, p = 0.38) nor for colonization rates of wound drains (TG 1: 4.8%, TG 2a: 10.5%, p = 0.27).Conclusions: Single-shot PAP had no adverse effects on the wound infection rate or the colonization rate of the wound drains compared with prolonged perioperative antibiotic prophylaxis. As a result, single-shot preoperative PAP is now applied to the majority craniosynostosis patients undergoing surgical correction in our unit.
Can Exercise Reduce the Autonomic Dysfunction of Patients With Cancer and Its Survivors? A Systematic Review and Meta-Analysis
Authors: Lavín-Pérez Ana Myriam , Collado-Mateo Daniel , Mayo Xián , Liguori Gary , Humphreys Liam , Jiménez Alfonso 
Published: August 2021

Background: Cancer therapies have increased patient survival rates, but side effects such as cardiotoxicity and neurotoxicity can lead to autonomic nervous and cardiovascular system dysfunction. This would result in a decrease in parasympathetic activity and the enhancement of sympathetic activity. Heart rate variability (HRV), which reflects autonomic modulation, is a valuable physiological tool since it correlates with cancer-related fatigue, stress, depression, and mortality in patients with cancer.Objective: This study aimed to analyze the effects of exercise programs on the autonomic modulation, measured by the HRV of patients with cancer and its survivors.Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed, and the quality of the articles was assessed with the Physiotherapy Evidence Database (PEDro) scale. The meta-analysis statistic procedure was performed by using RevMan software version 5.3.Results: From the 252 articles found, six studies were included in the review involving 272 participants aged 30–75 years. Exercise programs had a mean length of 10.4 ± 4.6 weeks, a frequency of 3 ± 1.4 days/week, and a mean duration of 78 ± 23.9 min. In time-domain HRV measures, exercise may increase in the SD of normal-to-normal intervals [p &lt; 0.00001, with a mean difference (MD) of 12.79 ms from 9.03 to 16.55] and a decreased root mean square of successive R–R interval differences (p = 0.002, with an MD of 13.08 ms from 4.90 to 21.27) in comparison with control groups (CG). The frequency-domain data reveal that the exercise group (EG) improve significantly more than the CGs in low frequency [absolute power: p &lt; 0.0001, with a standardized mean difference (SMD) of 0.97 from 0.61 to 1.34; relative power: p = 0.04, with an MD = −7.70 from −15.4 to −0.36], high-frequency [absolute power: p = 0.001, with a SMD of 1.49 from 0.32 to 2.66; relative power: p = 0.04, with an MD of 8.00 normalized units (n.u.) from 0.20 to 15.80], and low-to-high frequency ratio (p = 0.007 with an MD of −0.32 from −0.55 to −0.09).Conclusion: Exercise programs could lead to positive effects on the autonomic modulation of patients with cancer and its survivors. More beneficial changes may occur with resistance and endurance workouts. However, due to the low number of interventions performed, further research is needed to substantiate the findings and to provide additional insights regarding the exercise intensity required to increase the autonomic modulation of the patient.
Older Adults in the United States and COVID-19: A Qualitative Study of Perceptions, Finances, Coping, and Emotions
Authors: Goins R. Turner , Anderson Elizabeth , Minick Hannah , Daniels Heather 
Published: August 2021

Introduction: Older adults have the poorest coronavirus (COVID-19) prognosis with the highest risk of death due to complications, making their COVID-19 experiences particularly important. Guided by the stress-appraisal-coping theoretical model, we sought to understand COVID-related perceptions and behaviors of older adults residing in the United States.Materials and Methods: We used convenience sampling to recruit persons with the following inclusion criteria: Aged ≥ 65 years, English fluency, and U.S. residency. Semi structured in-depth interviews were conducted remotely and audio recorded between April 25, 2020 and May 7, 2020. Interviews were professionally transcribed with a final study sample of 43. A low-inference qualitative descriptive design was used to provide a situated understanding of participants' life experiences using their naturalistic expressions.Results: The mean age of participants was 72.4 ± 6.7. Slightly over half were female (55.8%), 90.6% were White, and 18.6% lived alone. The largest percentages of participants resided in a rural area (27.9%) or small city (25.6%). We identified four themes, including (1) risk perception, (2) financial impact, (3) coping, and (4) emotions. Most participants were aware of their greater risk for poor COVID-19 outcomes but many did not believe in their increased risk. Financial circumstances because of the pandemic varied with largely no financial impacts, while others reported negative impacts and a few reported positive impacts. Coping was problem- and emotion-focused. Problem-focused coping included precautionary efforts and emotion-focused coping included creating daily structure, pursuing new and/or creative activities, connecting with others in new ways, and minimizing news media exposure. Overall, emotional health was negatively affected by the pandemic although some participants reported positive emotional experiences.Conclusions: Perceiving themselves as high risk for COVID-19 complications, older adults used precautionary measures to protect themselves from contracting the virus. The precautionary measures included social isolation, which can negatively affect mental health. Older adults will need to be resourceful and draw on existing resources to cope, such as engaging in creative activities and new strategies to connect with others. Our findings underscore the importance of the preservation of mental health during extended periods of isolation by taking advantage of low-to-no-cost existing resources.
Declined Offers for Deceased Donor Kidneys Are Not an Independent Reflection of Organ Quality
Authors: King Kristen L. , Chaudhry Sulemon G. , Ratner Lloyd E. , Cohen David J. , Husain S. Ali , Mohan Sumit 
Published: August 2021

Key Points

13% of deceased donor kidneys are declined ≥100 times before transplantation, with 3% accumulating >1000 declined offersHard-to-place kidneys have more frequent delayed graft function, but similar long-term adjusted graft and patient survival outcomesFrequently declined kidneys may represent missed opportunities for earlier successful transplant for the patients who are passed over

Background
Deceased donor kidney offers are frequently declined multiple times before acceptance for transplantation, despite significant organ shortage and long waiting times. Whether the number of times a kidney has been declined, reflecting cumulative judgments of clinicians, is associated with long-term transplant outcomes remains unclear.

Methods
In this national, retrospective cohort study of deceased donor kidney transplants in the United States from 2008 to 2015 (n=78,940), we compared donor and recipient characteristics and short- and long-term graft and patient survival outcomes grouping by the sequence number at which the kidney was accepted for transplantation. We compared outcomes for kidneys accepted within the first seven offers in the match-run, after 8–100 offers, and for hard-to-place kidneys distinguishing those requiring >100 and >1000 offers before acceptance.

Results
Harder-to-place kidneys had lower donor quality and higher rates of delayed graft function (46% among kidneys requiring >1000 offers before acceptance versus 23% among kidneys with ≤7 offers). In unadjusted models, later sequence groups had higher hazard of all-cause graft failure, death-censored graft failure, and patient mortality; however, these associations were attenuated after adjusting for Kidney Donor Risk Index (KDRI). After adjusting for donor factors already taken into consideration during allocation, and recipient factors associated with long-term outcomes, graft, and patient survival outcomes were not significantly different for the hardest-to-place kidneys compared with the easiest-to-place kidneys, with the exception of death-censored graft failure (adjusted hazard ratio, 1.16, 95% CI, 1.05 to 1.28).

Conclusion
Late sequence offers may represent missed opportunities for earlier successful transplant for the higher-priority waitlisted candidates for whom the offers were declined.
Konsep Community Based Tourism Sebagai Strategi Pengembangan Kain Songket Sidemen Di Bali
Authors: Wangi Bhuanaputri Ni Kadek Ajeng , Dharma Putra I Putu Ryan , Wahyudi I Made Indra , Cantika Ratih Ni Made Ayu , Adam Marcellino Dominicius 
Published: August 2021

Kain Songket Sidemen yang autentik dalam mendukung pariwisata berkelanjutan di tengah pandemi COVID-19 di Desa Sidemen, Kecamatan Sidemen. Kain Songket Sidemen merupakan kain khas tradisional dengan proses pembuatan, motif kain yang kental dengan budaya Bali dan penuh makna. Kain Songket Sidemen ini menjadi produk wisata budaya khas Desa Sidemen. Metode penelitian yang digunakan adalah metode penelitian deskriptif dengan input data kualitatif. Teknik pengumpulan data dilakukan dengan observasi partisipatif, dan wawancara mendalam dengan yang terdiri dari Pengurus Desa Sidemen, pengerajin Kain Songket Sidemen, dan penjual Kain Songket Sidemen sebagai data primer, serta studi dokumentasi sebagai data sekunder. Strategi pengembangan Kain Songket Sidemen sebagai produk wisata budaya dengan konsep Community Based Tourism serta strategi Stabilitas, merupakan strategi untuk meningkatkan nilai-nilai kearifan budaya lokal Bali, meningkatkan pemasaran dan peran pemerintah dan masyarakat, serta meningkatkan kebutuhan pasar. Maka dari itu Kain Songket Sidemen perlu dikembangkan untuk mendukung kelestarian budaya dan menerapkan community based tourism dalam pengembangannya sehingga dapat meningkatkan kualitas pariwisata Bali upaya penerapan pariwisata berkelanjutan di era pandemi COVID-19. Tujuan penelitian ini, yaitu mengindentifikasi potensi dari pengembangan produk wisata budaya Kain Songket Sidemen dalam mendukung pariwisata berkelanjutan dengan menerapkan konsep community based tourism serta strategi pengembangan penjualan produk wisata budaya Kain Songket Sidemen yang autentik dalam mendukung pariwisata berkelanjutan di tengah pandemi COVID-19 di Desa Sidemen, Kecamatan Sidemen.
Les débuts mouvementés de l'observatoire météorologique du parc Montsouris à Paris (1869-1872)
Authors: Javelle Jean-Pierre , Rousseau Daniel 
Published: August 2021

L'observatoire météorologique du parc Montsouris à Paris a été créé en 1869 dans un contexte de controverses scientifiques et institutionnelles. Nous décrivons les premières années de son fonctionnement pendant une époque historiquement très troublée, marquée par la guerre franco-prussienne de 1870-1871 et la Commune de Paris. Les observations météorologiques effectuées à Montsouris permettent d'analyser la période 1869-1872 à Paris sur le plan climatologique. Depuis 1816, seuls cinq hivers ont connu des séquences de température moyenne inférieure à -6 °C sur 16 jours consécutifs. L'hiver très froid de 1870-1871 en fait partie ; s'y ajoutèrent la famine, due au siège de la capitale, et les bombardements de l'armée prussienne.
The meteorological observatory at the Parc Montsouris in Paris was created in 1869 in a context of scientific and institutional controversies. We describe the first years of its operation during a historically very troubled period, marked by the Franco-Prussian War of 1870-1871 and the Paris Commune. Meteorological observations made at Montsouris allow us to analyze the period 1869-1872 in Paris from a climatological point of view. Since 1816, only five winters have known sequences of average temperature, on 16 consecutive days, lower than -6 °C. The very cold winter of 1870-1871 was one of them, and also incurred the famine, due to the siege of the capital, and the bombings of the Prussian army.
The implied motion aftereffect changes decisions, but not confidence
Authors: Gallagher Regan M. , Suddendorf Thomas , Arnold Derek H. 
Published: August 2021

AbstractViewing static images depicting movement can result in a motion aftereffect: people tend to categorise direction signals as moving in the opposite direction relative to the implied motion in still photographs. This finding could indicate that inferred motion direction can penetrate sensory processing and change perception. Equally possible, however, is that inferred motion changes decision processes, but not perception. Here we test these two possibilities. Since both categorical decisions and subjective confidence are informed by sensory information, confidence can be informative about whether an aftereffect probably results from changes to perceptual or decision processes. We therefore used subjective confidence as an additional measure of the implied motion aftereffect. In Experiment 1 (implied motion), we find support for decision-level changes only, with no change in subjective confidence. In Experiment 2 (real motion), we find equal changes to decisions and confidence. Our results suggest the implied motion aftereffect produces a bias in decision-making, but leaves perceptual processing unchanged.