bluuebunny/crossref_metadata_2025_split huggingface dataset:
CUIDADOS FARMACÊUTICOS A PACIENTES PEDIÁTRICOS COM A SÍNDROME CONGÊNITA DO ZIKA VÍRUS
Authors: Rocha Beatriz Patrício , Morais de Oliveira Júnior José Agnaldo , Medeiros Kallyne , Cunha Lima Rosemary Souza , Costa Paulo Patrícia Trindade 
Published: March 2021

A Síndrome Congênita do Zika Vírus é uma importante enfermidade que emergiu no Brasil no ano de 2015 e não existe cura para esta síndrome. O tratamento medicamentoso visa melhorar a qualidade de vida dos portadores desta doença; entretanto, a terapia medicamentosa com o uso de múltiplos fármacos pode acarretar efeitos adversos e interações medicamentosas. O objetivo do trabalho foi realizar o cuidado farmacêutico com os pacientes pediátricos portadores da Síndrome Congênita do Zika Vírus. Trata-se de um garanestudo longitudinal realizado na Clínica de Fisioterapia da Universidade Estadual da Paraíba e no Centro Especializado em Reabilitação, ambos localizados na cidade de Campina Grande, PB, durante 8 meses. Foram 5 atendimentos por pacientes pediátricos, um a cada mês, utilizando a metodologia Phamacoterapy WorKup e a base de dados Micromedex®. No total, foram avaliados 23 pacientes, 29 prescrições e 71 medicamentos pertencentes a 9 classes farmacológicas. Os anticonvulsivantes foram os mais prescritos. Quanto à comorbidade existente, 8 pacientes apresentaram duas ou mais doenças etiologicamente relacionadas. Houve 35 (49,2%) interações medicamento-medicamento, destas, 8 (22,9%) com efeito grave, 23 (65,7%) moderado, 4 (11,4%) menor e nenhuma contraindicada, além de 32 interações medicamentoalimento e 43 medicamento-laboratório. Os problemas relacionados aos medicamentos identificados foram 42; a ineficácia [23 (55%)] sendo o mais frequente. Portanto, é fundamental o acompanhamento farmacoterapêutico aos pacientes pediátricos portadores da Síndrome Congênita do Zika Vírus para avaliar o uso racional destes medicamentos, no qual o Cuidado Farmacêutico pode fazer a diferença na utilização segura e adequada dos fármacos.
LEVANTAMENTO DE INFORMAÇÕES PARA ELABORAÇÃO DE GUIA DE ESTABILIDADE DE MEDICAMENTOS INJETÁVEIS PÓS RECONSTITUIÇÃO E DILUIÇÃO EM HOSPITAL MATERNO-INFANTIL
Authors: Barros Correia Gislayne , Mariz Batista Almária 
Published: March 2021

Fragilidades no processo de administração significam que a última barreira de segurança do paciente, em que os erros podem ser interceptados, foi rompida. Portanto, é necessário que estratégias seguras e eficazes sejam inseridas nas instituições para garantir a qualidade na assistência à saúde por meio da redução de erros de medicação. O objetivo do estudo consistiu em investigar informações adequadas e padronizadas sobre estabilidade de medicamentos para administração parenteral pós-diluição, para a elaboração de um guia com orientações pertinentes a respeito. Para tanto, foi utilizada como base a lista pactuada de medicamentos utilizados no Hospital do Seridó e consulta de informações técnico-científicas em fontes de elevada confiabilidade (Micromedex®, UpToDate®). Um total de 89 medicamentos foram analisados e fornecidas informações técnicas sobre seu uso parenteral. Dentre os medicamentos analisados, 64 (71,91%) podem estar envolvidos em incompatibilidade medicamentosa se administrados em dispositivo Y-site concomitantemente. Há poucos estudos que abordem este tema, o que também confere relevância ao estudo. Assegurar o fornecimento de informações de caráter técnico-científico e independentes sobre o medicamento é de responsabilidade do farmacêutico, contribuindo para evitar erros, consequentemente, melhorar a segurança do paciente.
Temperature adjusted cross section libraries used for criticality calculations
Authors: Refeat R. M. 
Published: March 2021

Abstract
The change in the temperature of the nuclear reactor components (fuel, moderator, coolant, and structural materials) is considered to be a significant source of reactivity variation. This change must be taken in account during criticality calculations for safety analysis of the reactor. Hence, the exact representation of temperature in the calculations is very important. In this paper, two PWR assemblies are simulated, solid 16 ⨯ 16 and annular 12 ⨯ 12 fuel assemblies. The infinite multiplication factor and its temperature dependent parameters are calculated for both fuel assemblies. Adjusted temperature dependent libraries are created using makxsf code to exactly represent the different temperature values used in the calculations. It is shown that the results obtained using adjusted cross section libraries are more reliable. The two fuel assembly types follow the same behavior despite the differences in their geometrical configuration. The introduction of annular fuel has a very small effect on the investigated neutronic parameters because the moderator to fuel ratio is preserved.
Dynamic fault tree analysis of auxiliary feedwater system in a pressurized water reactor
Authors: Fahmy R. A. , Gomaa R. I. 
Published: March 2021

Abstract
The safe and secure designs of any nuclear power plant together with its cost-effective operation without accidents are leading the future of nuclear energy. As a result, the Reliability, Availability, Maintainability, and Safety analysis of NPP systems is the main concern for the nuclear industry. But the ability to assure that the safety-related system, structure, and components could meet the safety functions in different events to prevent the reactor core damage requires new reliability analysis methods and techniques. The Fault Tree Analysis (FTA) is one of the most widely used logic and probabilistic techniques in system reliability assessment nowadays. The Dynamic fault tree technique extends the conventional static fault tree (SFT) by considering the time requirements to model and evaluate the nuclear power plant safety systems. Thus this paper focuses on developing a new Dynamic Fault Tree for the Auxiliary Feed-water System (AFWS) in a pressurized water reactor. The proposed dynamic model achieves a more realistic and accurate representation of the AFWS safety analysis by illustrating the complex failure mechanisms including interrelated dependencies and Common Cause Failure (CCF). A Simulation tool is used to simulate the proposed dynamic fault tree model of the AFWS for the quantitative analysis. The more realistic results are useful to establish reliability cantered maintenance program in which the maintenance requirements are determined based on the achievement of system reliability goals in the most cost-effective manner.
Range-kernel weak orthogonality of some elementary operators
Authors: Bachir Ahmed , Segres Abdelkader , Sayyaf Nawal A. 
Published: March 2021

Abstract
We study the range-kernel weak orthogonality of certain elementary operators induced by non-normal operators, with respect to usual operator norm and the Von Newmann-Schatten

p

p

-norm

(

1
≤
p
<
∞

)

\left(1\le p\lt \infty )

.
Exosomal-mediated transfer of OIP5-AS1 enhanced cell chemoresistance to trastuzumab in breast cancer via up-regulating HMGB3 by sponging miR-381-3p
Authors: Yu Qiang , Li Yinmou , Peng Shijun , Li Jing , Qin Xianxiong 
Published: March 2021

Abstract

Background
Long noncoding RNA OPA-interacting protein 5 antisense transcript 1 (OIP5-AS1) was confirmed to involve in the malignancy of breast cancer. However, whether exosomal OIP5-AS1 is implicated in trastuzumab resistance remains unclear.

Methods
The IC50 value of cells to trastuzumab, cell proliferation, migration, and apoptosis was analyzed by cell counting kit-8 assay, colony formation assay, transwell assay, or flow cytometry, respectively. The expression of OIP5-AS1 and microRNA (miR)-381-3p was detected using quantitative real-time polymerase chain reaction. Exosomes were isolated by ultracentrifugation and qualified by nanoparticle tracking analysis software. Western blot was used to detect the protein levels of tumor susceptibility gene 101 (TSG101), CD81, CD63, or high-mobility group protein B3 (HMGB3). The interaction between miR-381-3p and OIP5-AS1 or HMGB3 was confirmed by dual-luciferase reporter assay and pull-down assay. In vivo experiments were conducted using murine xenograft models.

Results
OIP5-AS1 was elevated in trastuzumab-resistant breast cancer cells, and OIP5-AS1 knockdown rescued trastuzumab sensitivity. Extracellular OIP5-AS1 was packaged into exosomes, which were secreted by trastuzumab-resistant cells, and could be absorbed by trastuzumab-sensitive cells in breast cancer. Importantly, intercellular transfer of OIP5-AS1 via exosomes enhanced trastuzumab resistance in vitro. OIP5-AS1 was a sponge of miR-381-3p; besides, miR-381-3p targeted HMGB3. Murine xenograft analysis showed exosomal OIP5-AS1 induced trastuzumab resistance in vivo. Exosomal OIP5-AS1 was dysregulated in the serum of breast cancer patients and might be a promising diagnostic biomarker in trastuzumab resistance.

Conclusion
Intercellular transfer of OIP5-AS1 by exosomes enhanced trastuzumab resistance in breast cancer via miR-381-3p/HMGB3 axis, indicating a potential therapeutic strategy to boost the effectiveness of trastuzumab in resistant breast cancer patients.
Disparity in clinical characteristics between 2019 novel coronavirus pneumonia and leptospirosis
Authors: Li BinBin , Bao ChunMiao 
Published: March 2021

Abstract

Objective
A cluster outbreak of patients with similar symptoms and computed tomographic (CT) images of COVID-19 were diagnosed with leptospirosis. This study was aimed to identify the clinical difference between leptospirosis and COVID-19, providing evidence for strategy optimization.

Methods
A cohort of leptospirosis patients were collected and compared with age- and gender-matched COVID-19 cases in the epidemiological investigation, chest CT scan, laboratory tests, and length of hospital stay.

Results
Compared with COVID-19, contacting floodwater and lack of family clustering were features of leptospirosis in epidemiological assessment. In the laboratory test, higher level of white blood cells (WBCs: (10.38 ± 4.56) × 109/L vs (6.45 ± 1.95) × 109/L, p < 0.001), C-reactive protein (CRP: (138.93 ± 73.03) mg/L vs (40.28 ± 30.38) mg/L, p < 0.001), Creatine ((88.27 ± 35.16) mmol/L vs (63.31 ± 14.50) mmol/L, p < 0.001), and a lower level of platelet ((152.93 ± 51.93) × 109/L vs (229.65 ± 66.59) × 109/L, p < 0.001) were detected on patients with leptospirosis.

Conclusion
Given the epidemiological differences and seasonal prevalence, it is important to suspect leptospirosis in cases with a similar presentation of COVID-19. The clinical disparities may facilitate the therapeutic management of these two diseases.
Stakeholder and Data-Driven Fall Screen in a Program of All-Inclusive Care for the Elderly: Quality Improvement Initiative
Authors: Gustavson Allison M. , Falvey Jason R. , LeDoux Cherie V. , Stevens-Lapsley Jennifer E. 
Published: March 2021

Background and Purpose:
The Program of All-Inclusive Care for the Elderly (PACE) delivers community-based long-term care services to low-income, nursing home eligible adults. In the PACE population, one of the most common reasons for hospitalizations is falls. The purpose of this quality improvement study was to create a stakeholder-driven process for developing a fall risk screen and evaluate how well this process discriminated injurious and noninjurious fallers.

Methods:
The quality improvement design was a prospective, longitudinal data collection for 5 PACE programs in Colorado. Physical therapists collected the Short Physical Performance Battery (SPPB) on participants at least annually. The Kotter practice change framework guided the processes for practice and organizational change in developing and implementing a fall screen.

Results and Discussion:
An iterative, stakeholder, and data-driven process allowed our team of researchers and a PACE program to establish a fall risk screen to stratify PACE participants. We provided feedback to PACE staff regarding screening rates and results on discrimination of faller status to promote continued uptake of screening and discussion regarding next steps. Rehabilitation therapists screened 66% of the PACE population, and participants were stratified into high risk (1-7 points) or low risk (8-12 points) based on the SPPB. Participants with low SPPB scores had 79% greater risk of a fall (risk ratio [RR] = 1.8; 95% confidence interval [CI], 1.5-2.1) and 86% greater risk of an injurious fall (RR = 1.9; 95% CI, 1.4-2.4), compared with those with high SPPB scores.

Conclusions:
Our study describes a collaboration to address fall rates in a PACE population. Program of All-Inclusive Care for the Elderly clinicians can use the identified cut-offs to stratify PACE populations at risk for falls and allocate scarce rehabilitation resources efficiently to best serve participants at highest risk, while using less resource-intensive interventions for those at lower risk.
The Affirmation Special Allocation Fund and Regional Economic in Indonesia
Authors: Soraya Amanda Petty , Qibthiyyah Riatu Mariatul 
Published: March 2021

Starting 2015, Government of Indonesia introduced Affirmation Special Allocation Fund (DAK). Affirmation DAK is expected to fund infrastructure, accessibility and improvement of basic services, as well as aiming to accelerate development in disadvantaged areas, border areas, outer islands, and transmigration areas. These targeted regions on average have low GRDP per capita. The purpose of this study is to determine the effect of Affirmation DAK on the regional economy in Indonesia. The existence of Affirmation DAK is expected to support equal distribution of basic infrastructure and services and accelerate development in Affirmation DAK receiving area which is a region with characteristics of disadvantaged areas, border areas, outermost islands and transmigration areas. This study uses panel data of 491 regencies/municipalities in 2011-2018 and using the fixed effect estimation method. Empirical results show that Affirmation DAK has not had a positive effect on GRDP per capita. Limiting estimation only to Affirmation DAK recipient regions, there is also no positive association between Affirmation DAK and GRDP per capita. The results of this study also show that the impact of Affirmation DAK is very small on the recipient area, implying that Affirmation DAK in its current form and existing pool fund size, has not yet an effective policy for regions exiting from “the lagging regions trap”. It is instead, still, revenue sharing and general allocation fund (DAU), that have consistent positive effect on regional economic growth, both are block grants that to an extent related to more discretionary to local governments in terms of use of fund.
Pembangkitan Massa Medan Skalar dan Boson Tera pada Model Simetri Kiri Kanan Termodifikasi Berdasarkan Grup Tera SU(3)_CâŠ—SU(2)_LâŠ—SU(2)_RâŠ—U(1)_Y
Authors: Istikomah Istikomah Istikomah 
Published: March 2021

Modified Left-Right Symmetry Model has been constructed based on Â the gauge group . In this model there is a left sector consisting of Standard Model particles with the addition of right-handed neutrino Â and the doublet scalar , while the particle pairs are in the right sector. In addition, also added scalar fields Â and Â which can be intermediaries of interaction between the two sectors. Scalar fields masses can be generated via scalar potensial with the result that Â . Whereas the mass of charged gauge bosons , the masses of neutral gauge bosons masses and the mass of photon is zero.
Sistem Informasi Spasial Berbasis Web pada Sebaran Sarana Perumahan dan Permukiman (Studi kasus)
Authors: Saputra Muhammad Dedy , Arham Zainul 
Published: March 2021

Kota Sekayu merupakan wilayah perkotaan yang menjadi pusat Pemerintahan Kabupaten Musi Banyuasin. Terjadinya peningkatan jumlah penduduk yang terus menerus, menunjukan bahwa pemerintah setempat hendaknya membangun berbagai sarana perumahan dan permukiman. Berdasarkan Permendagri Nomor 9 Tahun 2009 disebutkan bahwa penyerahan sarana perumahan dan permukiman harus berdasar kepada prinsip keterbukaan dimana masyarakat mengetahui dan diberi kemudahan untuk mengakses informasi sarana perumahan dan permukiman. Oleh karena itu, Badan Perencanaan Pembangunan Daerah (BAPPEDA) Kabupaten Musi Banyuasin pada bidang penelitian dan pengembangan bertugas memetakan sarana perumahan dan permukiman akan tetapi masih terdapat kendala pada sistem pengelolaan data yang masih statis, tidak terpusatnya data, belum adanya koordinat geografi, dan minimnya informasi yang didapat masyarakat tentang sarana perumahan dan permukiman. Penelitian ini bertujuan untuk menyediakan sistem informasi spasial yang dapat mengelola sebaran sarana perumahan dan permukiman di Kota Sekayu. Dalam penelitian ini digunakan bahasa pemrogramana PHP beserta database MySQL. Penelitian ini menghasilkan sistem informasi spasial berbasis web yang dapat digunakan oleh Badan Perencanaan Pembangunan Daerah (BAPPEDA) Kabupaten Musi Banyuasin untuk mengelola persebaran sarana perumahan dan permukiman.
Alternative Etiologies of Liver Disease in Children With Suspected NAFLD
Authors: Yodoshi Toshifumi , Orkin Sarah , Arce-Clachar Ana Catalina , Bramlage Kristin , Xanthakos Stavra A. , Valentino Pamela L. , Mouzaki Marialena 
Published: March 2021

OBJECTIVES:
To determine the prevalence of alternative causes of liver disease in a cohort of youth with overweight and obesity undergoing evaluation for suspected nonalcoholic fatty liver disease (NAFLD).

METHODS:
Multicenter, retrospective cohort study of patients aged ≤18 years with overweight and obesity and evidence of elevated serum aminotransferases and/or hepatic steatosis on imaging, referred for suspected NAFLD to Cincinnati Children’s Hospital Medical Center (2009–2017) or Yale New Haven Children's Hospital (2012–2017). Testing was performed to exclude the following: autoimmune hepatitis (AIH), Wilson disease, viral hepatitis (B and C), thyroid dysfunction, celiac disease, α-1 antitrypsin deficiency, and hemochromatosis.

RESULTS:
A total of 900 children with overweight and obesity (63% boys, 26% Hispanic ethnicity) were referred, with a median age of 13 years (range: 2–18). Most had severe obesity (n = 666; 76%) with a median BMI z score of 2.45 (interquartile range [IQR]: 2.2–2.7). Median alanine aminotransferase level at presentation was 64 U/L (IQR: 42–95). A clinically indicated liver biopsy was performed in 358 children (40%) at a median of 6 months (IQR: 1–14) post initial visit; of those, 46% had confirmed nonalcoholic steatohepatitis. Positive autoantibodies were observed in 13% of the cohort, but none met criteria for AIH. Only 19 (2%) were found to have other causes of liver disease, with no cases of viral hepatitis or Wilson disease detected.

CONCLUSIONS:
In a large, multicenter cohort, the vast majority of children with overweight and obesity with presumed or confirmed NAFLD tested negative for other causes of liver disease. In contrast to a previous pediatric report, no patient was diagnosed with AIH.
Adolescent Risk Behavior Screening and Interventions in Hospital Settings: A Scoping Review
Authors: Pfaff Nora , DaSilva Audrey , Ozer Elizabeth , Kaiser Sunitha 
Published: March 2021

CONTEXT:
Risky behaviors are the main threats to adolescents’ health; consequently, evidence-based guidelines recommend annual comprehensive risk behavior screening.

OBJECTIVE:
To review studies of adolescent risk behavior screening and interventions in urgent care, emergency department (ED), and hospital settings.

DATA SOURCES:
Our data sources included PubMed (1965–2019) and Embase (1947–2019).

STUDY SELECTION:
Studies were included on the basis of population (adolescents aged 10–25 years), topic (risk behavior screening or intervention), and setting (urgent care, ED, or hospital). Studies were excluded if they involved younger children or adults or only included previously identified high-risk adolescents.

DATA EXTRACTION:
Data extracted were risk behavior screening rates, screening and intervention tools, and attitudes toward screening and intervention.

RESULTS:
Forty-six studies were included; most (38 of 46) took place in the ED, and a single risk behavior domain was examined (sexual health [19 of 46], mood and suicidal ideation [12 of 46], substance use [7 of 46], and violence [2 of 46]). In 6 studies, authors examined comprehensive risk behavior screening, demonstrating low rates at baseline (∼10%) but significant increases with clinician reminder implementation. Adolescents and clinicians were highly accepting of risk behavior screening in all settings and preferred electronic screening over a face-to-face interview. Reported barriers were time constraints and limited resources.

LIMITATIONS:
Only 1 included study was a randomized controlled trial, and there was large heterogeneity of included studies, potentially limiting generalizability.

CONCLUSIONS:
Rates of adolescent risk behavior screening are low in urgent care, ED, and hospital settings. Our findings outline promising tools for improving screening and intervention, highlighting the critical need for continued development and testing of interventions in these settings to improve adolescent care.
A krónikus lymphoid leukaemia mai kezelésének interdiszciplináris kérdései
Authors: Szász Róbert , Illés Árpád 
Published: March 2021

Összefoglaló. A Bruton-féle tirozin-kinázt gátló ibrutinib és a
B-sejtes lymphoma-2-t gátló venetoklax a krónikus lymphoid leukaemia (CLL)
kezelésének egyre korábbi vonalában alkalmazható, és ezek mellett a
progressziómentes túlélés növekedése figyelhető meg. A célzott kismolekulákkal
végzett kezelés nemcsak a CLL lefolyását, de a betegek gondozását is alapvetően
megváltoztatta. A tartósan adagolt orális szerek mellett a betegek nagyobb
valószínűséggel jelennek meg a panaszaiknak megfelelő szakrendeléseken. Az új
típusú szerek hatásai és mellékhatásai mellett az alapvető
gyógyszer-interakciókra is fel kell hívni a figyelmet. Kiemelt fontosságú az
ibrutinib hypertoniát provokáló hatása, illetve a 6–16%-ban megjelenő
pitvarfibrilláció. Ez utóbbi ellátását a gyógyszer-interakciókon túl az
ibrutinib vérzékenységet okozó hatása is nehezíti. A CLL-lel, illetve annak
kezelésével kapcsolatos ismeretek a másodlagos daganatok, néhány
gastrointestinalis és bőrgyógyászati betegség megközelítése szempontjából is
fontosak. A venetoklax mellett potenciálisan kialakuló tumorlízis-szindróma
alkalmanként a nefrológusok bevonását igényli. A betegek gondozása, megfelelő
szakszerű ellátása és a betegutak optimalizálása érdekében a háziorvosok, a
sürgősségi ellátók és az egyéb szakellátó helyek szoros együttműködése szükséges
szakorvosi konzultáció keretei között. Orv Hetil. 2021; 162(9): 336–343.
Summary. Chronic lymphocytic leukemia (CLL) is ubiquitously treated
with novel agents. The Bruton’s tyrosine kinase inhibitor ibrutinib and the
B-cell lymphoma 2 inhibitor venetoclax can be used increasingly in earlier lines
of treatment with improved progression-free survival. Treatment with targeted
small molecules fundamentally changed not only the course of CLL but also the
care of patients. With the administration of long-term oral medications,
patients are more likely to show up at specialist clinics that match their
complaints. In addition to the effects and side effects of the new drugs,
attention should also be drawn to basic drug interactions. The effect of
ibrutinib on blood pressure and the ability to provoke atrial fibrillation in
6–16% of cases are of paramount importance. In addition to drug interactions,
the treatment of the latter is also complicated by the hemorrhagic effect of
ibrutinib. Knowledge on CLL and its treatment is also important in the approach
to secondary tumors, some gastrointestinal and dermatological diseases. The
potential for tumor lysis syndrome of venetoclax requires close collaboration
with nephrologists. In order to provide appropriate professional care and
optimize patient pathways, close co-operation between GPs, emergency care
providers and other specialist care facilities is required within the framework
of professional consultation. Orv Hetil. 2021; 162(9): 336–343.