bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic association analysis of the cardiovascular biomarker: N-terminal fragment of pro-B-type natriuretic peptide (NT-proBNP)
Authors: Yang Yuan , Zmuda Joseph M. , Wojczynski Mary K. , Thyagarajan Bharat , Christensen Kaare , Cvejkus Ryan K. , Kuipers Allison L. 
Published: March 2021

Background
NT-proBNP is a biomarker of cardiovascular disease (CVD). Little is known about the heritability and genetic variants associated with NT-proBNP. Therefore, we estimated the heritability of and examined genetic associations of SNPs in the BNP gene region with circulating NT-proBNP and prevalent CVD in 4,331 participants from the Long Life Family Study (LLFS).

Methods and results
Genotypes of 10 SNPs from the NPPB and NPPA regions that encode BNP and A-type natriuretic peptide, respectively, were tested for association with NT-proBNP and prevalent cardiovascular disease and risk factors. We performed analyses using the Sequential Oligogenic Linkage Analysis (SOLAR) program to account for family relatedness, and adjusted all models for age, sex, and field center. The mean age of the LLFS was 69.8 years (range 24–110) with 55.4% females. NT-proBNP was significantly heritable (h2 = 0.21; P = 4x10-14), and the minor alleles of rs632793 (p<0.001) and rs41300100 (p = 0.05) were independently associated with higher serum NT-proBNP levels. Additionally, the minor allele of rs632793 was significantly and consistently associated with lower prevalent CVD, including blood pressures, independent of NT-proBNP level (all P<0.05). Results for prevalent CVD, but not NT-proBNP levels, showed significant interaction by familial generation.

Conclusion
In this family-based study of subjects with exceptional longevity, we identified several allelic variants in the BNP gene region associated with NT-pro-BNP levels and prevalent CVD.
The Use and Meaning of the Past in Plato
Authors: Migliori Maurizio 
Published: March 2021

This essay is based on two premises. The first concerns the vision of writing proposed by Plato in Phaedrus and especially the conception of philosophical writing as a maieutic game. The structurally polyvalent way in which Plato approaches philosophical issues also emerges in the dialogues. The second concerns the birth and the development of historical analysis in parallel with the birth of philosophy.
On this basis the text investigates a series of data about the relationship between Plato and "the facts".
1) If we compare the Apology of Socrates with other sources, we discover a series of important “games” that Plato performs to achieve the results he proposes.
2) The famous passage of Phaedo 96A-102A, which concludes with the Ideas and with a reference to the Principles, expresses definite judgments on the Presocratics.
3) In his works Plato attributes to the sophists some merits, even if the outcome of their contri-bution is overall negative.
4) However, in the fourth complicated diairesis of the Sophist, there is a "sophist of noble stock", an educator who can only be Socrates.
5) Plato in the Sophist shows the weakness of the Gigantomachy, and proposes an adequate definition of the beings: the power of undergoing or acting. This reveals, before the Philebus and the Timaeus, the dynamic and dialectical nature of his philosophy
In summary, a multifocal vision emerges, adapted to an intrinsically complex reality.
A New Interpretation of the Noble Lie
Authors: Gonda Joseph 
Published: March 2021

“Could we contrive one noble lie?” implies there is one noble lie (Republic 414b). The Autochthony Claim (asserting the Best City’s citizens are equally brothers) and the Hierarchical Claim (asserting brother justifiably rules over brother) follow. The article argues the former is the “one” noble lie. It argues the claims are both normative and descriptive propositions; both descriptively true about worldly polities in Plato’s day and historically. While the Hierarchical Claim is normatively true of the Best City, the Autochthony Claim is normatively false. The article offers a tentative explanation why jointly they comprise a foundational myth of political life.
Platone e il vegetarianismo nel Timeo
Authors: Casella Federico 
Published: March 2021

L’articolo analizza la descrizione della natura delle piante e la tacita giustificazione del vegetarianismo fornite da Platone nel Timeo. Tale pratica alimentare sembra assumere un’utilità esclusivamente fisiologica: potrebbe darsi che Platone si fosse opposto a quanti professavano il vegetarianismo in qualità di mezzo necessario per purificare l’anima e per raggiungere la felicità, come gli orfici, i pitagorici, Empedocle ma anche il suo discepolo Senocrate. Attraverso il particolare valore attribuito a una dieta vegetariana, Platone priva di validità la pretesa degli altri filosofi: solo lo studio delle idee permette di ottenere la felicità.
Abstract. The aim of this paper is to analyse Plato’s description of plants and his tacit justification of vegetarianism in the Timaeus. This practice seems to possess exclusively a physiological relevance: I argue that Plato is opposing the idea of vegetarianism as a superior way to purify one’s soul and achieve happiness, how it was being professed by the Orphics, the Pythagoreans, Empedocles, and even by his disciple Xenocrates. In the Timaeus, with the justification of vegetarianism only for physiological purposes, Plato is discrediting other philosophers’ conception of vegetarianism and perfect life: only the study of the noetic world grants ultimate happiness.
Robustness of an airport double layer space truss roof
Authors: Piana Gianfranco , De Biagi Valerio , Chiaia Bernardino 
Published: March 2021

Abstract
Robustness analyses are very well referenced for concrete or steel frame structures but less for spatial structures; in particular for truss roofs. Here, we present a robustness analysis of an existing airport space structure. A finite element model was implemented based on the original design documents, where the structure is modeled as a spatial truss composed of elastic, perfectly hinged bars. With respect to five main design loading conditions, the most stressed bars among the top layer, the bottom layer and the diagonals, were alternately removed, and the stress variations in the remaining bars monitored. A total of fifteen analyses with removal of either the most stretched or the most compressed bar were run. Also, reductions of the most stressed bars’ axial stiffness were considered to investigate the effects of such local reductions on the global structural flexibility. Linearized global buckling analyses were also conducted to point out again the effect of a global loss of stiffness, due to local losses. The study gives basic information about the general behavior of the structure in case of failure, or damage, of a key element. Results show that this kind of lightweight and efficient structures are very sensitive to local losses, since their redistribution capabilities are not large.
An overview of the natural force density method and its implementation on an efficient parametric computational framework
Authors: de Souza Márcio S. V. , Pauletti Ruy M. O. 
Published: March 2021

Abstract
The new paradigms of parametric modelling have been proving promising on the advance of systems for analysis and design of taut (or tensile) structures. With this premise, the presented work consist on the development with a form-finding tool for Computer Aided Design(CAE) and Computer Aided Engineering (CAE) integration using VPL (Visual Programming Language), in the context of parametric modelling. The methods used in the implementation are the Force Density Method (FDM) and the Natural Force Density Method (NFDM), taking advantage of the linear solution approach provided, suitable for fast form-finding computational procedures.
The program is implemented as a Grasshopper plug-in and it is named BATS (Basic Analysis of Taut Structures), which enables parametric definition of boundary conditions for the form-finding. The program structure and benchmarks with other available Grasshopper plug-ins for taut structures form-finding are presented, showing considerably superior performance using BATS.
Variation in translations of biblical quotations in Žemčiūga Teologiška by Simonas Vaišnoras (1600)
Authors: Kietytė Samanta 
Published: March 2021

The aim of this article is to investigate the translation variations of Biblical quotations in Simonas Vaišnoras’ Žemčiūga Teologiška. This text is a translation of Adam Francisci’s theological tractate Margarita Theologica, and it was published in 1600. From the first sight, it seems that Vaišnoras tried to make his translation as similar to the original as possible. That is why, in many cases, his translation looks literal and a lot of syntactic constructions and the word order in it seem to be closer to Latin than the Lithuanian language. However, a closer look at the translations of Biblical quotations shows a different situation. In some cases, Biblical quotations are translated differently in different places of the text. Those variations include lexemes, word order, morphological features. Some of those variations are determined by the variations of the translation’s source Margarita Theologica. Another group of the variations appear because the author chose to translate not from Margarita Theologica, but from the Luther Bible. Nevertheless, more than a half of the cases (16 from 28) cannot be explained by the influence of translation sources. It shows that Simonas Vaišnoras was quite free translating this text and sometimes let himself deviate from the original. This article also focuses on the nature of variations – they are classified by the levels of language. The majority of variations are made at the lexical level (43 %), a little bit less are at the syntactic level (37 %), and the least are at the morphological level (20 %).
Recovery from desflurane and sevoflurane anaesthesia after prolonged surgery - A comparative study using Index of Consciousness (IoC) monitoring
Authors: Yadav Rahul , Honwad Manish , Choubey Raj Kumar , Bhushan Kirti , Singh Geetanjali , Kulkarni Sachin Narayan 
Published: March 2021

The present study compared the recovery from desflurane and sevoflurane anaesthesia in patients after prolonged surgery using Index of Consciousness (IoC) monitoring scale.A total of 50 patients between 18 to 60 years of age, scheduled to undergo prolonged surgeries (lasting for more than 120 minutes) were included in this study and randomly divided in two groups (Group A: Desflurane; Group B: Sevoflurane) of 25 patients each.The patients who received Desflurane had better recovery characteristics than Sevoflurane. Results showed that for attaining value of IoC- 95, mean time required by patients of group A was 1.82 (± 0.50) minutes as compared to 5.36 (± 0.95) minutes by group B. Similarly for attaining value of IoC-99 (i.e. state of complete consciousness), mean time required by patients of group A was 11.04 (± 1.62) minutes as compared to 22.84 (± 4.85) minutes by group B. The results were significantly different (p&#60; 0.05) for both the values of IoC. The present study concludes that inhalation based desflurane anaesthesia has a faster recovery than sevoflurane anaesthesia in prolonged surgeries, when both are guided by IoC monitoring.
Achondroplasia and emergency caesarean section: A case report
Authors: Palaria Urmila , Joshi Kamal Nayan , Upreti Yeeti 
Published: March 2021

Achondroplasia is the commonest variety of rhizomelic dwarfism, which results from abnormal cartilage formation at epiphyseal growth plates. The peculiar facial features, bony deformities and systemic abnormalities often pose a difficulty in administration of anesthesia, particularly in the parturients. There are very few reported cases of spinal anesthesia in achondroplastic parturients, because of its feared high risks. We reported, two cases of achondroplastic parturients with short stature, planned for emergency lower segment caesarean section (LSCS), in view of cephalo-pelvic disproportion under spinal anesthesia. We discussed the anesthetic issues to achondroplastic parturients and finally did under spinal anesthesia. Besides, a myriad of problems encountered in these patients warrant a careful pre-anesthetic evaluation to warrant patients' safety and affirmative procedure outcomes.
Analysis of diffusion tensor imaging metrics for glioma grading at 3T: Comparison with histopathology as gold standard
Authors: Shukla Shreya , Kashikar Ritu , Desai Shrinivas 
Published: March 2021

Advanced neuro-imaging like Diffusion Tensor Imaging (DTI) is a non-invasive technique with enormous potential in glioma grading. To assess the diagnostic accuracy of DTI metrics for differentiating low grade from high grade gliomas.This is a diagnostic accuracy study of 38 patients with glioma. DTI was performed on Siemens 3T MRI machine. Post- processing of data was done by placing circular ROI of 30 mm on tumor (T), peritumoral edema (PT) and normal appearing white matter (WM) in the corresponding contra lateral hemisphere, avoiding cystic/necrotic/hemorrhagic regions. ROIs were then automatically transferred to corresponding λ1, λ2, λ3 and FA maps. FA, ADC, AD, RD, Cp, Cs and Cl were obtained. DTI parameters and histopathological tumor grades were analyzed statistically.An independent-samples t-test showed a significant difference between low grade and high grade tumours in eight out of 21 DTI parameters of which ADC (T), AD (T) and RD (T) showed a sensitivity of 100%. 72% and 12%; specificity of 76.9%, 100%, and 100%; PPV of 89.3%, 100% and 100%; NPV of 100%, 65% and 34.32% respectively. Diagnostic Accuracy was highest for ADC (T), ADC (PT), AD (T), RD (T), Cl (T), Cp (T).DTI is recommended as part of glioma imaging for optimizing patient outcome as this study reveals high diagnostic accuracy and sensitivity for ADC, AD, RD, Cl and Cp of solid tumoral part and ADC, Cl of peritumoral region to differentiate High from Low Grade tumours.
Paget’s Disease of Bone in Patients under 40 Years
Authors: Maatallah Kaouther , Ben Nessib Dorra , Labbène Emna , Ferjani Hanane , Bouaziz Mouna , Kaffel Dhia , Hamdi Wafa 
Published: March 2021

Paget’s disease of bone (PDB) is a focal disorder of accelerated skeletal remodelling that is uncommon in patients under the age of 40 years; it is more prevalent in older individuals. We report two cases of PDB diagnosed in early adulthood at the Mohamed Kassab Institute of Orthopedics, La Manouba, Tunisia. The first case was a 35-year-old male patient who presented in 2011 with a seven-month history of hip pain. The second case was a 39-year-old female patient who presented 2014 with chronic lower back pain. The PDB diagnosis was confirmed with clinical, biological and radiological investigations. Both patients were doing well on follow-up. Some previous cases have been reported in the literature, differing from the presented cases in some aspects; data of PDB features at differing ages is still insufficient. Early recognition of this clinical entity in young patients is important as early treatment can affect the progression of the disease.

KEYWORDS
Paget’s Disease of Bone; Young Adults; Diagnosis; Case Report; Tunisia.
Upaya Meningkatkan Ketrampilan Motorik Halus melalui Kegiatan Finger Painting pada Anak Usia Dini di Kober Rofa Sukadana Lampung Timur
Authors: Oktaviana Anita , Basri Basri , Hasanah Uswatun - 
Published: March 2021

Tujuan dari penelitian ini adalah untuk meningkatkan keterampilan motorik halusn melalui kegiatan Finger painting di KOBER Rofa Sukadana Lampung Timur. Jenis penelitian ini adalah Penelitian Tindakan Kelas yang dilaksanakan melalui 2 siklus.Untuk mengetahui tingkat perkembangan anak peneliti menggunakan lembar observasi. Berdasarkan hasil penelitian yang telah dilakukan, ditemukan bahwa kegiatan Finger painting dapat meningkatkan keterampilan motorik halus anak di KOBER Rofa Sukadana Lampung Timur. Hasil tersebut dapat dilihat dari hasil penilaian siklus II yang menunjukan bahwa keterampilan motorik halus sudah mencapai kriteria perkembangan yang diharapkan yaitu BSH (Berkembang Sesuai Harapan). Hasil yang sama dapat diilihat saat proses kegiatan Finger painting berlangsung, anak sudah dapat mengkoordinasi mata dan tangannya. Sehingga dapat disimpulkan bahwa anak-anak sudah dapat menggunakan tangan dan jari-jarinya untuk melukis dengan baik serta jari–jari anak nampak lentur pada saat kegiatan melukis.
Peran Petugas Lingkungan Pondok Sosial (Liposos) dalam Pengelolaan Diapres pada Klien di UPTD Liposos Kabupaten Jember
Authors: Habsari Ghaniyu Putri , Rokhmah Dewi , Nafikadini Iken 
Published: March 2021

Diapers merupakan alat yang berupa popok sekali pakai berdaya serap tinggi yang terbuat dari plastik dan campuran bahan kimia untuk menampung sisa-sisa metabolisme seperti air seni dan feses. Diapres masuk dalam limbah bahan berbahaya dan beracun yang disebut limbah B3. Limbah B3 adalah sisa suatu usaha atau kegiatan yang mengandung B3. Penggunaan diapers dewasa pada orang tua dan orang dengan gangguan jiwa yang tidak memiliki kesadaran dan mengalami pelemahan fisik banyak digunakan sebagai alternatif kontrol kemih, sebanyak 42,3% orang yang dirawat dirumah sakit yang mengalami penurunan mobilitas, kemampuan fisik dan kesadaan menggunakan diapers dewasa sebagai alternatif kontrol kemih dalam proses perawatan. Penelitian ini merupakan penelitian kuantitatif yang bertujuan untuk menganalisis peran petugas lingkungan pondok sosial (LIPOSOS) dalam pengelolaan diapers pada klien ODGJ di UPTD. Hasil penelitian menunjukkan bahwa dari 5 responden penelitian dalam pengelolaan diapers di UPTD. LIPOSOS yang digunakan yaitu dengan cara penimbunan, penguburan dan pembakaran. Sehingga dari penelitian yang dilakukan dapat disimpulkan bahwa belum ada pengelolalan secara baik dan benar mengenai pengolahan diapers di UPTD. LIPOSOS. Pemilihan diapers kurang memadai terkait dengan ukuran dan merk yang digunakan.
On the Evaluation of Online Payment Systems in Turkey Based on Users’ Perspectives
Authors: SİNEK Seda , ŞAYKOL Ediz 
Published: March 2021

In this study, the factors affecting the present and future of payment systems in Turkey together with the technical payment systems are analyzed, and the supported payment systems in Turkey are examined by a survey from the users’ perspectives. While the widespread use of smart devices, rapid developments in technology, globalization, improvements in financial areas, the development of commercial and financial activities have led to an increase in domestic and international payment transactions. Consequently, the shopping habits change among many subjects. People's efforts to access information with the fastest, the most practical and the safest are seen as the main reasons for the change of today's world. Merchandising habits also started to show parallel development and change to the internet. The fact that e-commerce can be used with all banks thanks to virtual POSs has further strengthened the link between international e-commerce companies and users. Thus, payment systems became more widespread. The use of payment systems, payment options offered to customers on online shopping sites, campaigns, installments and postponement opportunities has become widespread with the support of credit card security.
The need for payment systems has increased due to the fact that people go to a store in their daily routines and see shopping as a waste of time, and nowadays shopping and buy and sell are so easy in online environments. Thus, various payment systems have been initiated. The main purpose of this study is to evaluate the payment systems infrastructure in Turkey from two different users’ perspectives. The data gathered via questionnaires in terms of end users who have completed their orders in any e-commerce site using direct payment systems, and the developers who have programming practive on e-commerce sites having integrated payment systems. The statistical results are discussed with analytical evaluations.
Increasing ESP Lifetime by Employing Novel Non-Corrosive Acid System for Scales Removal
Authors: Gamal Hany , Al-Afnan Saad , Elkatatny Salaheldin , Bahgat Mohamed 
Published: March 2021

Abstract
The scales precipitated on the electric submersible pump (ESP) will lead to trapped heat, lower the motor's cooling capacity, decrease the pump lifetime, and finally pump failure. Removal of oil field scales commonly requires low pH acid that can cause corrosion, hydrogen sulfide evolution, ferric and ferrous hydroxide precipitation, iron sulfide as a by-product, and/or sulfur precipitation. Scales typically occur in the near wellbore, tubing, downhole pumps, and surface equipment. A mineral deposition is widespread with a change in pressure, temperature, pH, and incompatible mixing between injected seawater and formation water.
This paper presents a new scale dissolver that is non-corrosive and has a high scale dissolution performance for barium sulfate scales. The study explains a series of comprehensive experimental lab tests such as X-ray diffraction (XRD), X-ray fluorescence (XRF), brine compositional analysis, fluid compatibility and stability, solubility test, precipitation tendency for the dissolved solids, and corrosion test to evaluate and simulate the field application of the new dissolver using two field scale types that mainly contain barium sulfate (BaSo4) scales.
The obtained successful results indicated that the novel dissolver had a great dissolution efficiency for two real barium scale samples as the results showed that the dissolution rate recorded 91.3 and 78.4 % at 90 °C for samples 1 and 2 respectively. The novel dissolver showed a very low precipitation tendency for the scale dissolved solids (1.9 and 3.2 % for samples 1 and 2 respectively). Without any additives of corrosion inhibitors, the corrosion rate was 0.00376 lb/ft2 at 1000 psi and 50 °C for 6 hours.
The obtained successful results will help to dissolve the barium sulfate scales, maintain the ESP performance, increase the lifetime, and save extra cost for the pump operational problems due to scale precipitations.
Asociaciones entre contratransferencia y características del paciente en psicoterapia psicoanalíticaa
Authors: Sanchez Lívia Fração , Serralta Fernanda Barcellos 
Published: March 2021

Objetivo: explorar las reacciones de contratransferencia de los terapeutas en la fase inicial de la psicoterapia psicoanalítica (entre las sesiones 4 y 5) y verificar las posibles asociaciones entre estas y las características personales del paciente (sociodemográficas, psicológicas y psicopatológicas). Método: estudio naturalista, transversal, correlacional y observacional con enfoque descriptivo-analítico. La muestra consta de 180 pares de pacientes y terapeutas, de los cuales 180 eran pacientes adultos (32.82 ± 12.66 años) y 48 terapeutas (32.69 ± 10.01 años). Resultados: la contratransferencia se ve afectada por la edad del paciente, los aspectos psicológicos de su vida anterior (traumas y apego parental) y elementos de su personalidad (habilidades de empatía y mecanismos defensivos), pero no por los síntomas que presenta. Conclusiones: los hallazgos respaldan la literatura científica, que señala la relevancia de las experiencias infantiles y las características de personalidad del paciente para evocar patrones específicos de contratransferencia en el terapeuta. Conocer tales relaciones puede ayudar a los clínicos a identificar sus propias reacciones y usarlas terapéuticamente, según corresponda.