bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acceptance and perceived value of non-invasive malaria diagnostic tests in malaria-endemic countries
Authors: Owusu Ewurama Dedea Ampadu , Campillo Ana , Daily Jennifer , Ding Xavier C. 
Published: September 2021

Abstract
Background
The diagnosis of malaria, using microscopy or rapid diagnostic tests (RDTs), requires the collection of capillary blood. This procedure is relatively simple to perform but invasive and poses potential risks to patients and health workers, arising from the manipulation of potentially infectious bodily fluids. Less or non-invasive diagnostic tests, based on urine, saliva or requiring no sampling, have the potential to generate less discomfort for the patient and to offer simpler and less risky testing procedures that could be safely performed by untrained staff or even self-performed. To explore the potential acceptance and perceived value of such non-invasive tests, an online, international survey was conducted to gather feedback from National Malaria Control Programme (NMCP) representatives.

Methods
An online survey comprising nineteen questions, available in English, French or Spanish, was emailed to 300 individuals who work with NMCPs in malaria-endemic countries. Answers were collected between November and December 2017; responses were qualitatively analysed to identify key themes and trends and quantitatively analysed to determine average values stratified by region.

Results
Responses were received from 70 individuals, from 33 countries. Approximately half of the respondents (52 %) considered current blood-based tests for malaria to be minimally invasive and non-problematic in their setting. For these participants, non-invasive tests would only be of interest if they brought additional performance improvements, as compared with the performance of microscopy and RDTs. Most respondents were of the view that saliva-based (80 %) and urine-based (66 %) tests would be more readily acceptable among children than blood-based tests. Potential use-case scenarios of interest for both saliva- and urine-based tests were ease-of-testing by community health workers, additional surveillance, self-testing, and outbreak investigation. Many respondents (41 %) thought that if saliva-based tests retailed at <$0.50 per unit they could largely replace conventional RDTs, whereas only 25 % of respondents thought a similarly priced urine-based test would do so.

Conclusions
Although limited to NMCP stakeholders, this survey indicated that current tests for malaria, based on capillary blood, are generally perceived to be minimally invasive and non-problematic. Non-invasive tests, especially if saliva-based, would be welcome if they could match or out-perform the price and performance of current blood-based tests.
Crosstalk between N6-methyladenosine modification and circular RNAs: current understanding and future directions
Authors: Wang Xin , Ma Rui , Zhang Xilin , Cui Lian , Ding Yangfeng , Shi Weimin , Guo Chunyuan , Shi Yuling 
Published: September 2021

AbstractN6-methyladenosine (m6A) is a prevalent internal modification in eukaryotic RNAs regulated by the so-called “writers”, “erasers”, and “readers”. m6A has been demonstrated to exert critical molecular functions in modulating RNA maturation, localization, translation and metabolism, thus playing an essential role in cellular, developmental, and disease processes. Circular RNAs (circRNAs) are a class of non-coding RNAs with covalently closed single-stranded structures generated by back-splicing. CircRNAs also participate in physiological and pathological processes through unique mechanisms. Despite their discovery several years ago, m6A and circRNAs has drawn increased research interest due to advances in molecular biology techniques these years. Recently, several scholars have investigated the crosstalk between m6A and circRNAs. In this review, we provide an overview of the current knowledge of m6A and circRNAs, as well as summarize the crosstalk between these molecules based on existing research. In addition, we present some suggestions for future research perspectives.
Assessment of life factors affecting the experience of depressive symptoms in adolescents: a secondary analysis using the Korea Youth Risk Behavior Survey
Authors: Lee Jongha , Han Changsu , Ko Young-Hoon , Lee Moon-Soo , Yoon Ho-Kyoung 
Published: September 2021

Abstract
Background
Adolescents may experience several changes in their lifestyle, such as social activity and school life, which makes them vulnerable to developing a depressive disorder. Therefore, the present study aimed to identify the factors affecting the experience of depressive symptoms during adolescence.

Methods
We conducted a secondary analysis using the 2019 Korean Youth Risk Behavior Web-based survey data, including a total of 57,303 middle and high school students selected from among 400 schools. Factors such as dietary habits, physical activity levels, time spent studying, duration of internet use, and other health risk behaviors were included in the analysis. Logistic regression analysis was performed to identify factors that predict the risk of experiencing depressive symptoms.

Results
The perceived stress of Korean adolescents showed a tendency to increase with age, and high school seniors and girls were more likely to report depressive symptoms. Perceived health status, academic performance, time spent studying, physical activity, duration of internet use, and effort to control weight were associated with individual experiences of depressive symptoms.

Conclusion
We identified factors that influence the experience of depressive symptoms in adolescents. Our results suggest the possibility that the purpose of students’ physical activities and their leisure activity preferences may be related to their emotional status. We suggest that activities that are appropriate to the culture and lifestyle of adolescents should be recommended to reduce the occurrence of depressive symptoms.
Concomitant familial hypocalciuric hypercalcemia and single parathyroid adenoma: a case report
Authors: Marstrand Simone Diedrichsen , Tofteng Charlotte Landbo , Jarløv Anne , Borgwardt Line , Schwarz Peter 
Published: September 2021

Abstract
Background
Primary hyperparathyroidism (PHPT) is a common endocrine disorder and the most frequent benign cause of hypercalcemia. PHPT is characterized by autonomous hypersecretion of parathyroid hormone (PTH), regardless of serum calcium levels. Familial hypocalciuric hypercalcemia (FHH) is a rare, benign syndrome only affecting the regulation of calcium metabolism. FHH is an autosomal-dominant genetic disease with high penetrance, caused by an inactivating variant in the CASR gene encoding the calcium-sensing receptor (CaSR). We present a unique case of concomitant PHPT and FHH without clinically actionable variants in MEN1.

Case presentation
A 47-year-old Caucasian man with severe hypercalcemia, genetic FHH, and initially normal parathyroid scintigraphy was referred for endocrine evaluation due to nonspecific symptoms. Biochemical evaluation showed elevated serum ionized calcium and PTH. The calcium–creatinine clearance ratio was low. All other biochemical measures were normal, including kidney function. Genetic evaluation was redone and confirmed FHH. A new parathyroid scintigraphy showed a significant single adenoma corresponding to the lower left gland. The patient underwent parathyroidectomy, and a parathyroid adenoma was removed. A reduced level of hypercalcemia persisted due to FHH.

Conclusions
The correct diagnosis of the underlying cause of hypercalcemia is important to ensure the right treatment. Patients with FHH should avoid operative treatment, and PHPT should be differentiated from MEN1 to determine whether surgery should include parathyroidectomy with removal of one adenoma or 3.5 hyperplastic parathyroid glands.
Consolidated drained (CID) behavior of fibre reinforced cemented Toyoura sand in triaxial loading conditions
Authors: Safdar Muhammad , Newson Tim , Shah Faheem 
Published: September 2021

AbstractThe effects of fibre (0–3 %) and cement (0–3 %) additives, on Toyoura sand were examined under consolidated drained compression and extension loading conditions. All samples were prepared to a target dry density value (e.g., $${\rho }_{d}$$

ρ
d

= 1.489 g/cm3) of Toyoura sand using under-compaction moist tamping technique. In compression, the unreinforced specimens exhibited a behavior of medium dense sand and reached a peak deviator stress (qp) at approximately 4 % axial strain ($${\epsilon }_{a}$$

ϵ
a

) for the varying mean effective stresses, pʹ (i.e. 50–400 kPa). The peak drained strength increases in fibre reinforced cemented specimens were found to be up to 132 % (lower effective stresses) and 243 % (higher effective stresses), while, the drained strength increases at critical state for the fibre reinforced cemented specimens were found to be up to 105 % (lower effective stresses) and 245 % (higher effective stresses). Overall, the fibre and cement additives increased the stiffness, peak and strength at critical state of pure Toyoura sand but were found to be least effective in extension loading. Moreover, the stress ratio, peak and critical state stress ratios increase with the addition of fibres and cement. The secant modulus shows limited increases for the fibre reinforced specimens. However, a significant improvement in the secant modulus is observed for the fibre reinforced cemented specimens. For both unreinforced and reinforced specimens there is a decrease in volumetric strain with greater effective stresses or in other words, the rate of dilation decreases with increases in effective stresses. The fibre and cement additives also increased the strength parameters (frictional angle, cohesion), dilatancy angle, slope of the critical state line, and decreased the state parameter of pure Toyoura sand.
Climatization and luminosity optimization of buildings using genetic algorithm, random forest, and regression models
Authors: Mota Bruno , Albergaria Miguel , Pereira Helder , Silva José , Gomes Luis , Vale Zita , Ramos Carlos 
Published: September 2021

AbstractWith the rise in popularity of artificial intelligence, coupled with the growing concern over the environment, there has been a surge in the use of intelligent energy management systems. Additionally, as more buildings transition into the smart grid and, consequently, more energy and environmental data is gathered, there has been a significant increase in the number of data-driven approaches for building management systems. This paper proposes a methodology that aims to optimize the climatization and luminosity inside a building, using a genetic algorithm, a random forest, and two polynomial models. The proposed methodology enables the real-time management of the building taking into account the user needs and preferences. Air conditioner units and light systems are optimized to minimize energy costs, while also improving the air quality and considering the users’ temperature and luminosity preferences. This paper shows the results achieved, by the proposed solution, in an office building case study. The promising results demonstrate the possibility of minimizing energy costs while maximizing the users’ comfort.
Electric vehicles as distribution grid batteries: a reality check
Authors: Malya Prasad Prakash , Fiorini Laura , Rouhani Mohammadhadi , Aiello Marco 
Published: September 2021

AbstractThe current transition towards electric mobility implies that a significant portion of electricity is drawn by and stored in the electric vehicle’s (EV) batteries. Vehicle-to-grid (V2G) technologies can potentially give distribution system operators access to such energy to provide ancillary services, while remunerating the vehicle owners for their availability to participate. Although the benefits of stabilization and grid efficiency improvements are clear, is it appealing and lucrative for the vehicle owners to participate in such services? In this work, we answer this question by modelling the V2G system and performing economic projections of the possible benefits for EV owners. In particular, we present a novel way of parametrizing the electric vehicle driving profile and the V2G energy transfer to compute battery degradation costs. A profit model is developed to evaluate the profit earned by the vehicle owners offering their batteries. The profit is estimated on the basis of the owner’s inclination to buy and sell energy from the grid based on the electricity price. Using data of the German electricity market, we estimate a profit of 662 €/EV/Year for a vehicle with 100 kWh capacity, 95% battery round trip efficiency and driving 52 km per day. The remuneration is meaningful and can have the potential to encourage EV owners to participate in V2G service.
Methodology for identifying technical details of smart energy solutions and research gaps in smart grid: an example of electric vehicles in the energy system
Authors: Christensen Kristoffer , Ma Zheng , Demazeau Yves , Jørgensen Bo Nørregaard 
Published: September 2021

AbstractSimulations, especially agent-based simulation, are able to facilitate the investigation of smart energy solutions and business models, and their impacts on the energy system and involved stakeholders. Technical details, alternatives, and multiple options for what-if scenarios influence simulation quality, but no methodology available to support the investigation. This paper proposes a method for identifying technical details of smart energy solutions in the energy system and identifying research gaps in the smart grid context with EV solutions as an example. The method includes the investigation of the state-of-the-art EV solutions by scoping review and the allocation of the scoping review results into the Smart Grid Architecture Model framework with three dimensions (Domains, Zones, and interoperability layers). The quantitative scoping review results in a total number of 240 references and 10 references match the criteria based on the qualitative scoping review. The results show that the most popular EV use case within the targeted scope is the V2G concept, and 6 out of the 10 references discuss the EVs’ potentials to work as energy storage. Seventeen features are identified by mapping the EV use cases (solutions and business models) into the three dimensions (domain, zone, and interoperability layers) of the SGAM framework. The process at the Zone layer is the most popularly covered (mentioned 64 times), and enterprise at the Zone layer and communication in the interoperability layer are the least covered (mentioned 4 times each).
Industrial consumers’ electricity market participation options: a case study of an industrial cooling process in Denmark
Authors: Fatras Nicolas , Ma Zheng , Jørgensen Bo Nørregaard 
Published: September 2021

AbstractIn a deregulated market context, industrial consumers often have multiple market participation options available to bid their flexible consumption in electricity markets and thereby reduce their electricity bill. Yet most participation strategies for demand response are developed in a fixed and predefined set of submarkets. Meanwhile, little literature has compared multiple market options for market participants. Therefore, this paper proposes a comparative approach between available market options to evaluate savings from different market participation options. More specifically, this study implements an optimisation program in Python to investigate the impacts of changes in an industrial process’ flexibility on savings with different market participation options. The optimisation program is tested with a case study of an industrial cooling process in three Danish submarkets (day-ahead, intraday, and regulating power markets). The market participation options are formed by different combinations of these three submarkets, and the type and amount of process flexibility are varied by changing time and load constraints in the optimisation program. The results show that bidding in market options with multiple submarkets yields higher savings than single-market bidding, but that increases in available flexibility impact savings in each market option differently. Increased flexibility will only bring additional savings if it allows to take further advantage of price variations in a market option. Additionally, increases in savings with flexibility depend on the considered type of flexibility. These changes in relative savings between market options at each flexibility level imply that the optimal market option is not a static choice for a process with variable operating conditions. The optimal market option for an industrial consumer depends not only on market price signals, but also on the type and amount of available flexibility.
Introduction: Carolee Schneemann (1939–2019)
Authors: White Kenneth 
Published: September 2021

Abstract
This is an introduction to a dossier on the work and life of Carolee Schneemann (1939–2019). Schneemann was celebrated in a memorial service at Judson Memorial Church in New York. The service included Malcolm Goldstein's improvisational performance on violin titled Soundings for Carolee. The seven essays in this dossier, derived in part from remarks delivered at the service, comprise a range of critical “soundings” of Schneemann's work and life.
RNA profiling of laser microdissected human trophoblast subtypes at mid-gestation reveals a role for cannabinoid signaling in invasion
Authors: Gormley Matthew , Oliverio Oliver , Kapidzic Mirhan , Ona Katherine , Hall Steven , Fisher Susan J. 
Published: September 2021

ABSTRACTHuman placental architecture is complex. Its surface epithelium, specialized for transport, forms by fusion of cytotrophoblast progenitors into multinucleated syncytiotrophoblasts. Near the uterine surface, these progenitors assume a different fate, becoming cancer-like cells that invade its lining and blood vessels. The latter process physically connects the placenta to the mother and shunts uterine blood to the syncytiotrophoblasts. Isolation of trophoblast subtypes is technically challenging. Upon removal, syncytiotrophoblasts disintegrate and invasive cytotrophoblasts are admixed with uterine cells. We used laser capture to circumvent these obstacles. This enabled isolation of syncytiotrophoblasts and two subpopulations of invasive cytotrophoblasts from cell columns and the endovascular compartment of spiral arteries. Transcriptional profiling revealed numerous genes, the placental or trophoblast expression of which was not known, including neurotensin and C4ORF36. Using mass spectrometry, discovery of differentially expressed mRNAs was extended to the protein level. We also found that invasive cytotrophoblasts expressed cannabinoid receptor 1. Unexpectedly, screening agonists and antagonists showed that signals from this receptor promote invasion. Together, these results revealed previously unseen gene expression patterns that translate to the protein level. Our data also suggested that endogenous and exogenous cannabinoids can affect human placental development.
ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling
Authors: Asaro Antonino , Sinha Rishabhdev , Bakun Magda , Kalnytska Oleksandra , Carlo-Spiewok Anne-Sophie , Rubel Tymon , Rozeboom Annemieke , Dadlez Michal , Kaminska Bozena , Aronica Eleonora , Malik Anna R. , Willnow Thomas E. 
Published: September 2021

ABSTRACT
Sortilin is a neuronal receptor for apolipoprotein E (apoE). Sortilin-dependent uptake of lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into neuromodulators that induce anti-inflammatory gene expression in the brain. This neuroprotective pathway works with the apoE3 variant but is lost with the apoE4 variant, the main risk factor for Alzheimer's disease (AD). Here, we elucidated steps in cellular handling of lipids through sortilin, and why they are disrupted by apoE4. Combining unbiased proteome screens with analyses in mouse models, we uncover interaction of sortilin with fatty acid-binding protein 7 (FABP7), the intracellular carrier for PUFA in the brain. In the presence of apoE3, sortilin promotes functional expression of FABP7 and its ability to elicit lipid-dependent gene transcription. By contrast, apoE4 binding blocks sortilin-mediated sorting, causing catabolism of FABP7 and impairing lipid signaling. Reduced FABP7 levels in the brain of AD patients expressing apoE4 substantiate the relevance of these interactions for neuronal lipid homeostasis. Taken together, we document interaction of sortilin with mediators of extracellular and intracellular lipid transport that provides a mechanistic explanation for loss of a neuroprotective lipid metabolism in AD.
Screening Hamstring Injury Risk Factors Multiple Times in a Season Does Not Improve the Identification of Future Injury Risk
Authors: OPAR DAVID A. , RUDDY JOSHUA D. , WILLIAMS MORGAN D. , MANIAR NIRAV , HICKEY JACK T. , BOURNE MATTHEW N. , PIZZARI TANIA , TIMMINS RYAN G. 
Published: September 2021

ABSTRACT

Purpose
To determine if eccentric knee flexor strength and biceps femoris long head (BFlh) fascicle length were associated with prospective hamstring strain injury (HSI) in professional Australian Football players, and if more frequent assessments of these variables altered the association with injury risk.

Methods
Across two competitive seasons, 311 Australian Football players (455 player seasons) had their eccentric knee flexor strength during the Nordic hamstring exercise and BFlh architecture assessed at the start and end of preseason and in the middle of the competitive season. Player age and injury history were also collected in preseason. Prospective HSIs were recorded by team medical staff.

Results
Seventy-four player seasons (16%) sustained an index HSI. Shorter BFlh fascicles (<10.42 cm) increased HSI risk when assessed at multiple time points only (relative risk [RR], 1.9; 95% confidence interval [CI], 1.2–3.0). Neither absolute (N) nor relative (N·kg−1) eccentric knee flexor strength was associated with HSI risk, regardless of measurement frequency (RR range, 1.0–1.1); however, between-limb imbalance (>9%), when measured at multiple time points, was (RR, 1.8; 95% CI, 1.1–3.1). Prior HSI had the strongest univariable association with prospective HSI (RR, 2.9; 95% CI, 1.9–4.3). Multivariable logistic regression models identified a combination of prior HSI, BFlh architectural variables and between-limb imbalance in eccentric knee flexor strength as optimal input variables; however, their predictive performance did not improve with increased measurement frequency (area under the curve, 0.681–0.726).

Conclusions
More frequent measures of eccentric knee flexor strength and BFlh architecture across a season did not improve the ability to identify which players would sustain an HSI.