bluuebunny/crossref_metadata_2025_split huggingface dataset:
Educational textbooks in digital surroundings
Authors: Fredskild Trine Ungermann , Frederiksen Kirsten 
Published: December 2021

The Danish educations, as well as the Danish society, are influenced by technology in many ways. This amongst other influences the student’s choices regarding educational learning material. These issues, however, are not solely issues in relation to Danish educations but can be generalized across contexts.
This article, however, presents a discussion of the findings in a Danish study regarding the use of educational textbooks among students in Denmark. The study examines the use of the traditional educational textbooks in terms of how it is used, to what extent it is used, the students' wishes regarding textbooks vs online books and if there are educational and gender differences in their preferences. The study also investigates the student way of handling the textbooks such as sharing, copying, selling and buying etc. in the discussion section the study will compare themes identified in this study across educational contexts, and will thus not solely focus on Danish education contexts.
Empirically, the study builds on a survey conducted among students in the Bachelor Programmes, the Vocational Educational Programmes regarding the Health Care Educations and in the General Upper Secondary Schools. The study includes a response from 1146 students.
The article discusses the findings with perspectives such as work methods, communication, and interaction, and concludes among others that even though the students still prefer the textbooks, the ebooks in some ways supplement this use in a beneficial manner.
The article argues that the textbook and the ebook should not be seen as each other’s competitors but rather as each other’s supplement in terms of learnings styles.
Seroprevalence and lethality by SARS-CoV-2 in indigenous populations of Latin America and the Caribbean: a systematic review
Authors: Hernández-Vásquez Akram , Chavez-Ecos Fabian , Barrenechea-Pulache Antonio , Comandé Daniel , Bendezu-Quispe Guido 
Published: December 2021

Background
Latin America and the Caribbean (LAC) has presented some of the highest numbers of cases and deaths due to COVID-19 in the world. Even though indigenous communities represent 8% of the total population in this region, the impact of COVID-19 on this historically vulnerable population has only been briefly explored. Thus, this study aimed to estimate the seroprevalence and lethality attributable to SARS-CoV-2 in the indigenous population of LAC.

Methods
A systematic review was conducted utilizing multiple databases (registry PROSPERO: CRD42020207862). Studies published in English, Spanish or Portuguese were selected between December 1st, 2019, and April 14th, 2021. The evaluation of the quality of the study was carried out utilizing the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. A qualitative synthesis of the data analyzed was conducted following the MOOSE and PRISMA declarations.

Results
Fifteen studies met the inclusion criteria. Eleven studies were carried out in a Brazilian population, three in a Mexican population, and one in a Colombian population. Four studies reported data about the seroprevalence of SARS-CoV-2 in indigenous populations of Brazil (range: 4.2–81.65%). Twelve studies reported lethality in indigenous people (eight in Brazil, three in Mexico, and one in Colombia). In Brazil, a lethality of 53.30% was described in a hospital setting and between 1.83% and 4.03% in community studies. In Mexico, the lethality of COVID-19 ranged between 16.5% and 19.9%. Meanwhile, in Colombia, a lethality of 3.41% was reported. Most studies were deemed to be of good quality.

Conclusions
Despite COVID-19 affecting indigenous populations of LAC, there is limited evidence of the seroprevalence and lethality of the infection by SARS-CoV-2 in this population. Future investigations should ensure standardized methods that allow comparability among studies and ensure the precision of the results obtained.
Natural Resource Management to Support Tourism Using Circular Economics Business Model: Case in Jatirejoyoso Village, Malang Regency, Indonesia
Authors: Mukhlis Imam , Hidayah Isnawati , Pratama Andik , Amir Mas’ud Anudiyan , Agustin Grisvia , Seprillina Linda 
Published: December 2021

Poverty alleviation and rural development has become one of priority for Indonesian government. It requires the contribution from local government to work hand in hand with various stakeholders in order to develop their local area and people based on their potential resources. The research aims to establish sustainable business model for rural development. One of the example is Jatirejoyoso village, Malang Regency that prepare their self to establish a tourism site which focus on agroecological farming system and circular economy concept. Thus, this research is conducted in Jatirejoyoso Village, Malang Regency. The research uses qualitative approach using DBR (Design Based Research). Moreover, this research uses SWOT analysis and BMC (Business Model Canvas) analysis. The data collected by doing FGD (Focus Group Discussion), in-depth interview, documentation and observation. The research’s informants are farmers, official rural government, leader of local community development program, and youth people. The research’s findings concludes that (1) Jatirejoyoso Village has potential to be developed into tourism area by managing their natural resource in agricultural sector and optimizing the farmer’s involvement, (2) The local communities independently initiate and develop the tourism spot, (3) The local people and authorities start to manage their natural resource, for instance by establishing refugia park nearby paddy field, (4) The local people has collective action’s awareness in order to sustainably optimize their potential to improve the livelihoods using circular economy approach.
Anti-Inflammatory and Analgesic Evaluation of Parinari curatellifolia Methanol Leaf Extract on Albino Rats
Authors: Fakai I. M. , Abdulhamid A. , Dada Alhassan Yunusa 
Published: December 2021

Aim: This research was designed to evaluate the anti-inflammatory and analgesic activities of Parinari curatellifolia methanol leaf extract in albino rats.
Methodology: Phytochemical screening was carried out using standard methods. Anti-inflammatory activity of the extract was done using egg albumin and formalin induced hind paw edema model. Analgesic effect was evaluated using hot plate induced pain and acetic acid induced writhing test. For each model twenty (20) rats were used, divided into five (5) groups of four (4) rats each.
Results: Parinari curatellifolia revealed the presence of alkaloids, flavonoids, tannins and phenols while steroids, anthraquinone, terpenoids and glycoside were not detected. For the egg albumin induced inflammation, the group treated with the standard drug (indomethacin) and the group that received the highest dose of the extract were significantly lower (P<0.05) than all the other groups with percentage inhibitions at 25.56% and 24.44% respectively there was no significant difference (P>0.05). For the formalin induced anti-inflammatory activity, at the 1st hour, the normal control group had its paw volume significantly different (P<0.05) from the treated groups. This trend was observed at the 2nd, 3rd and 4th hour. The hot plate method results revealed significant increased (P<0.05) in the analgesic activity of PCMLE at 400mg/kg body weight and the drug treated group when the control was compared with the treated groups with percentage inhibition of 34.32% and 52.94% respectively. The acetic acid induced writhing test revealed that the extract at the three doses of 100, 200 and 400 mg/kg body weight, showed a significant (P<0.05) percentage inhibition of 32.31%, 36.92% and 47.69%, respectively compared to negative control.
Conclusion: This justifies the use of Parinari curatellifolia locally in the management of pain and inflammation.
Parents' Stress and Children's Psychological Problems during the COVID-19 Outbreak in Saudi Arabia: A Cross-Sectional Study
Authors: Aljaber Maitham Jaber , Alqadeeb Maria Mahdi , Hijji Alsaleem Jassim , Al Ameen Sadiq Fadhel , Alhashem Ahmad Ibrahim , Alzahrani Safa Ibrahim 
Published: December 2021

The first outbreak of (COVID-19) was in the Chinese city of Wuhan at the end of December 2019 in the form of acute pneumonia. COVID-19 is a serious and highly infectious disease that affected 245,621,992 cases worldwide, leading to a dramatic loss of everyday lifestyle and negatively impacting people's psychological status. This paper shows Parents' Stress and Children's Psychological Problems during this pandemic.
Objectives: This work determined the psychological impacts of the Coronavirus Disease 2019 (COVID-19) pandemic on parents and children.
Methods: Parents who have children aged between 4 and 16 years old (n=424) completed an online questionnaire using QuestionPro and gave written informed consent. The questionnaire was distributed through social media (WhatsApp, Telegram ) from December 6th to January 5th, 2020-2021. We excluded all responses that came from outside Saudi Arabia. Also, we excluded participants who did not have children; if the parent had more than one child, they were asked to report on one child only. Parents described the difficulties they faced, the parent-child dyadic stress, and their children's behavioral and emotional complications during the pandemic. The participants filled the depression Anxiety Stress Scale (Dass21) and the Strengths and Difficulties Questionnaire (SDQ) scale.
Results: There were significant impacts on the mental health of the public. Our findings demonstrated that the COVID-19 outbreak had remarkable psycho-social effects on children and their parents.The results showed that younger parents were more affected than older parents,Q6 (r = 0.150, p<0.01), DASS stress (r = -0.266, p<0.01), DASS anxiety (r = -0.201, p<0.01), and DASS depression (r = -0.265, p<0.01),but there was no significant psychological impact of having COVID-19. Those who had relatives who died from COVID were at a higher risk of depression (r=0.006, p<0.05). Having a child diagnosed with mental illness seems to have increased the risk of depression, anxiety, and stress of parents. There was a significant association between parents' mental health and their children's psychological adjustment.
Conclusions: Quarantining is stressful, especially for parents who also have work and school obligations. This circumstance puts parents at a greater risk of distress and might prevent them from being supportive parents. This, in turn, can lead to psychological symptoms in children. Governmental actions should consider the implications of lockdown on families and their mental health.
Recommendation for Future Research: since this study had only focused on one child if parents have more than one with a limited number of participants, we recommended that further research be carried on a larger sample size to see whether there are any similarities in the findings.
Pain Reduction in Rheumatoid Arthritis Patients Who Use Opioids: A Post Hoc Analysis of Phase 3 Trials of Baricitinib
Authors: Pope Janet E. , Lee Yvonne C. , Curtis Jeffrey R. , Mo Daojun , Xie Li , Dickson Christina L. , Schlichting Douglas E. , Cardoso Anabela , Simon Lee S. , Taylor Peter C. 
Published: December 2021

ObjectivePain reduction with baricitinib was assessed in patients with rheumatoid arthritis (RA) who either used opioids or did not use opioids during three randomized, double‐blind phase 3 trials.MethodsAnalysis populations were as follows: i) baricitinib 4 mg once daily versus placebo groups integrated from RA‐BEAM (NCT01710358) for patients with inadequate response (IR) to methotrexate, RA‐BUILD (NCT01721057) with IR to conventional disease‐modifying antirheumatic drugs, and RA‐BEACON (NCT01721044) with IR to at least one tumor necrosis factor inhibitors; ii) baricitinib 2 mg versus placebo from RA‐BUILD and RA‐BEACON; and iii) adalimumab 40 mg every other week versus placebo from RA‐BEAM. Pain was measured by the Patient Assessment of Pain Visual Analog Scale. Analysis of covariance modeling assessed differences in pain reduction between treatments at each time point through Week 24, with an interaction term to test heterogeneous treatment effects across opioid users and nonusers.ResultsBaricitinib 4 mg had greater pain reduction versus placebo in opioid users and nonusers (P < 0.05) at all time points starting from Week 1; the pain reduction was similar between opioid users and nonusers. Baricitinib 2 mg had greater pain reduction versus placebo in opioid users and nonusers starting at Week 4. A significant difference in pain reduction was not observed for adalimumab versus placebo in the opioid users but was observed in nonusers at all time points.ConclusionPain reduction was observed and was similar between opioid users and nonusers with baricitinib 2 mg and 4 mg but not adalimumab in this post hoc analysis.
3D Printed Ti3C2Tx MXene/Cellulose Nanofiber Architectures for Solid‐State Supercapacitors: Ink Rheology, 3D Printability, and Electrochemical Performance
Authors: Zhou Guoqiang , Li Mei‐Chun , Liu Chaozheng , Wu Qinglin , Mei Changtong 
Published: December 2021

AbstractDirect ink writing technology is capable of using 2D MXene to construct 3D architectures for electrochemical energy storage (EES) devices that are normally difficult to achieve using conventional techniques. However, to meet specific rheological requirements for 3D printing, a large amount of MXene is needed in the ink, resulting in a severe self‐restacking structure after drying. Herein, a series of cellulose nanofibers (CNFs) with different morphologies and surface chemistries are applied to enhance the rheology of the MXene‐based inks with exceptional 3D printability. Various 3D architectures with superior shape fidelity and geometric accuracy are successfully printed using the optimized hybrid ink at a low solid content, generating self‐standing, hierarchically porous structures after being freeze‐dried, which improves surface area accessibility, ion transport efficiency, and ultimately, capacitive performance. A solid‐state interdigitated symmetrical supercapacitor is further 3D printed, which delivers an areal capacitance of 2.02 F cm−2 and an energy density of 101 μWh cm−2 at a power density of 0.299 mW cm−2, and maintains a capacitance retention rate of 85% after 5000 cycles. This work demonstrates the integration of 1D CNFs and 2D MXene in 3D printing technology to prepare customized, multiscale, and multidimensional architectures for the next generation of EES devices.
COCu: A Robust Self‐Regenerative Hydrogel with Applicability as Both Hydrated Gel Dressing and Dry Suture for Seamless Tissue Fixation and Repair
Authors: Hu Tian , Chan Chuncheung , Lin Min‐Zhao , Bu Huaitian , Liu Bin , Jiang Gang‐Biao 
Published: December 2021

AbstractSelf‐regenerative hydrogels have recently been developed, and represent a special type of self‐healing hydrogels with the ability to restore a dehydrated hydrogel with physical damage. In this study, a self‐regenerative hydrogel (COCu) based on two chitosan polymers assembled by slow‐released Cu2+ is developed. The COCu hydrogel displays an excellent regeneration ability after being dehydrated and fractured. By simple hydration at room temperature, the fragments of the dehydrated gel fuse into one seamless whole, thereby preserving the mechanical properties and functionalities of the original hydrogel. The regeneration process can be conducted repeatedly after different methods of dehydration (natural volatilization, heat drying, lyophilization) and various modes of deconstruction (flakes, powder, lumpy sponge, etc.). Furthermore, the COCu hydrogel provides ultra‐stretchability, and it can be stretched into thin (0.01–0.1 mm) filaments, which, when dried (dtCOCu), can be used as suture lines. Moreover, when used as a dry suture, it regenerates into the hydrogel in the presence of the tissue fluid, forming an excellent sealant to immobilize tissues and seamlessly seal wounds. The fast self‐regeneration allows for its facile application as both a hydrated gel dressing and dry suture, and offers customized strategies for fixing and repair of different wounds in soft tissues.
T7 Phage as an Emerging Nanobiomaterial with Genetically Tunable Target Specificity
Authors: Yue Hui , Li Yan , Yang Mingying , Mao Chuanbin 
Published: December 2021

AbstractBacteriophages, also known as phages, are specific antagonists against bacteria. T7 phage has drawn massive attention in precision medicine owing to its distinctive advantages, such as short replication cycle, ease in displaying peptides and proteins, high stability and cloning efficiency, facile manipulation, and convenient storage. By introducing foreign gene into phage DNA, T7 phage can present foreign peptides or proteins site‐specifically on its capsid, enabling it to become a nanoparticle that can be genetically engineered to screen and display a peptide or protein capable of recognizing a specific target with high affinity. This review critically introduces the biomedical use of T7 phage, ranging from the detection of serological biomarkers and bacterial pathogens, recognition of cells or tissues with high affinity, design of gene vectors or vaccines, to targeted therapy of different challenging diseases (e.g., bacterial infection, cancer, neurodegenerative disease, inflammatory disease, and foot–mouth disease). It also discusses perspectives and challenges in exploring T7 phage, including the understanding of its interactions with human body, assembly into scaffolds for tissue regeneration, integration with genome editing, and theranostic use in clinics. As a genetically modifiable biological nanoparticle, T7 phage holds promise as biomedical imaging probes, therapeutic agents, drug and gene carriers, and detection tools.
Workflow Engineering in Materials Design within the BATTERY 2030+ Project
Authors: Schaarschmidt Joerg , Yuan Jie , Strunk Timo , Kondov Ivan , Huber Sebastiaan P. , Pizzi Giovanni , Kahle Leonid , Bölle Felix T. , Castelli Ivano E. , Vegge Tejs , Hanke Felix , Hickel Tilmann , Neugebauer Jörg , Rêgo Celso R. C. , Wenzel Wolfgang 
Published: December 2021

AbstractIn recent years, modeling and simulation of materials have become indispensable to complement experiments in materials design. High‐throughput simulations increasingly aid researchers in selecting the most promising materials for experimental studies or by providing insights inaccessible by experiment. However, this often requires multiple simulation tools to meet the modeling goal. As a result, methods and tools are needed to enable extensive‐scale simulations with streamlined execution of all tasks within a complex simulation protocol, including the transfer and adaptation of data between calculations. These methods should allow rapid prototyping of new protocols and proper documentation of the process. Here an overview of the benefits and challenges of workflow engineering in virtual material design is presented. Furthermore, a selection of prominent scientific workflow frameworks used for the research in the BATTERY 2030+ project is presented. Their strengths and weaknesses as well as a selection of use cases in which workflow frameworks significantly contributed to the respective studies are discussed.
The safety and feasibility of laparoscopic redo surgery for recurrent Crohn’s disease: A comparative clinical study of over 100 consecutive patients
Authors: Ogino Takayuki , Sekido Yuki , Hata Tsuyoshi , Miyoshi Norikatsu , Takahashi Hidekazu , Uemura Mamoru , Yamamoto Hirofumi , Doki Yuichiro , Eguchi Hidetoshi , Mizushima Tsunekazu 
Published: December 2021

AbstractBackgroundDespite advances in medical treatments, most patients with Crohn's disease (CD) will still require surgery, with 20%‐50% needing redo surgery within 10 years after the primary procedure. There is no consensus on the application of laparoscopic redo surgery for recurrent CD.MethodsThis study included 107 patients with CD who underwent surgery from 2012 to 2020 at Osaka University Hospital. All procedures were laparoscopic. Patients were grouped based on whether the surgery was redo or primary for evaluation of the safety and feasibility of laparoscopic redo surgery.ResultsThe study included 40 patients undergoing redo surgery and 67 having primary surgery. The median age at the time of the procedure was higher for those undergoing redo surgery (43 years vs 34 years, P < 0.0031), as were the duration of CD (16.5 years vs 8.3 years, P < 0.0012) and number of operating minutes (231.0 min vs 169.0 min, P < 0.0001). The remnant bowel length was shorter in the redo surgery group (270.0 cm vs 410.0 cm, P < 0.0001). Rates of open conversion were comparable between the two groups (10.0% vs 3.0%, P = 0.127), as were postoperative complications (32.5% vs 20.9%, P = 0.1812).ConclusionsThese results suggest that laparoscopic redo surgery is safe and feasible, with comparable conversion rates and postoperative complications in experienced institutions.
Use of the Vineland‐3, a measure of adaptive functioning, in CLN3
Authors: Dang Do An N. , Thurm Audrey E. , Farmer Cristan A. , Soldatos Ariane G. , Chlebowski Colby E. , O'Reilly Julie K. , Porter Forbes D. 
Published: December 2021

AbstractProgressive vision loss and neurocognitive impairment are early and frequent presentations in CLN3 disease. This highlights neurodevelopmental functioning as critical to the disease, but limits the neuropsychological test repertoire. We evaluated the convergent validity of the Vineland Adaptive Behavior Scales as a potential outcome measure. In a prospective observational study of 22 individuals (female:male 11:11; 6–20 years‐old) with a molecular diagnosis of CLN3, we used generalized linear models and Spearman correlations to quantify the relationship of the adaptive behavior composite (ABC) standard score with established outcomes of verbal IQ (VIQ) and disease severity (Unified Batten Disease Rating Scale, UBDRS) scores. We analyzed ABC changes in 1‐year follow‐up data in a subset of the same cohort (n = 17). The ABC and VIQ, both standard scores, exhibited a strong positive correlation in cross‐sectional data (r = 0.81). ABC and UBDRS scores were strongly and positively correlated in cross‐sectional data (rrange = 0.87–0.93). Participants' ABC scores decreased slightly over the 1‐year follow‐up period (mean change, 95% CI: −5.23, −2.16). The convergent validity of the Vineland‐3 for use in CLN3 is supported by its relationships with the established outcomes of VIQ and UBDRS. Future longitudinal research, including replication in other cohorts and evaluation of sensitivity to change, will be important to establish utility of the Vineland‐3 for monitoring change in CLN3.