bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stopping DNA Damage: A Newly Discovered Protein-Enhancing DNA Repair Mechanisms
Authors:   Anatomical Researches and Skills Centre, Tbilisi, Georgia, Svanishvili Giorgi 
Published: December 2024

Endogenous factors, such as reactive oxygen species, and exogenous factors, including ionizing radiation, ultraviolet light, and chemical agents frequently cause DNA damage. This damage compromises genomic stability, leading to mutations, cellular dysfunction, and diseases such as cancer and neurodegenerative disorders. To counteract these threats, cells utilize DNA repair pathways including direct reversal, base excision repair, nucleotide excision repair, mismatch repair, and double-strand break (DSB) repair. These mechanisms are essential for maintaining genomic integrity and ensuring the accurate transfer of genetic information.

Deinococcus radiodurans exhibits extraordinary resistance to DNA-damaging agents through a combination of strategies, including an efficient DNA repair system and specialized DNA damage response proteins. Among these, DdrC is a unique DNA-binding protein that recognizes and stabilizes damaged DNA, preventing single-strand breaks from escalating into DSBs. Structural studies show that DdrC functions as a dimer with two distinct DNA-binding sites, enabling it to scan DNA for lesions and compact damaged regions. This compaction not only stabilizes DNA but also aids in preserving nucleoid integrity under extreme ­conditions.

The ability of DdrC to bind and compact damaged DNA suggests potential applications in medicine and biotechnology. In cancer therapy, DdrC could disrupt repair mechanisms in tumor cells, enhancing the effects of existing treatments. Its role in stabilizing DNA makes it a candidate for mitigating age-related genomic instability and protecting neurons in neurodegenerative diseases. However, challenges remain, including its bacterial origin, the need for adaptation to human systems, and the development of precise delivery methods.

This review provides an overview of DNA damage and repair mechanisms, the properties of DdrC, and its potential for advancing DNA repair-based therapies. While further research is required, DdrC represents a promising step toward innovative approaches to addressing genomic instability.
Klasifikasi Kelayakan Penerima Bantuan Langsung Tunai Bagi UMKM di Kota Cimahi Menggunakan Algoritma Naïve Bayes
Authors: Sugianto Castaka Agus , Sari Putri Nurlaela 
Published: December 2024

Dinas Sosial Kota Cimahi merupakan bagian dari instansi pemerintahan di Kota Cimahi. Dinas Sosial melaksanakan program yang ditetapkan pemerintah, yaitu program Bantuan Langsung Tunai untuk UMKM. Dalam pelaksanaan program ini, banyak pelaku UMKM yang mengeluh karena tidak menerima bantuan, sementara beberapa pelaku UMKM lainnya dianggap memiliki usaha besar dan pendapatan yang cukup justru mendapatkan bantuan. Oleh karena itu, penelitian ini melakukan pengolahan informasi dengan menggunakan data mining untuk mengelompokkan Kelayakan Penerima Bantuan Langsung Tunai bagi UMKM di Kota Cimahi dengan menggunakan Algoritma Naïve Bayes. Diharapkan hasil dari proses ini dapat digunakan sebagai bahan evaluasi bagi pemerintah. Pada penelitian ini, peneliti mengkategorikan data penerima bantuan langsung tunai UMKM menjadi “Layak” dan “Tidak Layak” dengan menggunakan teknik klasifikasi dalam data mining melalui Algoritma Naïve Bayes. Model data mining dihasilkan menggunakan RapidMiner, dengan nilai Probabilitas untuk kelas “Layak” sebesar 0,485 yang dibulatkan menjadi 0,48, sedangkan nilai Probabilitas untuk kelas “Tidak Layak” adalah 0,515 yang dibulatkan menjadi 0,51. Dari total 202 data untuk class “Layak” sebanyak 98 data, dan class “Tidak Layak” sebanyak 104 data. Dengan melakukan 3 (tiga) opsi pengujian yaitu 1 (satu) kali uji coba, 5 fold cross validation, dan 10 fold cross validation, algoritma Naïve Bayes menunjukkan tingkat Akurasi 100%, Presisi 100%, Recall 100%, dan AUC 1.00. Oleh karena itu, dapat disimpulkan bahwa hasil pengujian dengan algoritma Naïve Bayes adalah signifikan.

Kata Kunci— Kelayakan, data mining, klasifikasi, algoritma naïve bayes
O INSTITUTO DE PESQUISAS E ESTUDOS AFRO-BRASILEIROS (IPEAFRO) NA CONSTRUÇÃO DE UMA EDUCAÇÃO ANTIRRACISTA
Authors: Luis Barros Reis - Natal, RN (Brasil) Heverton 
Published: December 2024

O Instituto de Pesquisas e Estudos Afro-brasileiros (IPEAFRO) é um acervo público e gratuito, que tem como missão, valorizar a história, a memória e as culturas negras africanas e afro-brasileira. Neste sentido, objetiva-se refletir sobre a educação antirracista promovida pelo IPEAFRO, dando visibilidade ao acervo do instituto. O objetivo associa-se à pergunta: como o IPEAFRO promove uma educação antirracista? Para tal feito, adota-se uma metodologia histórico-crítica e técnica bibliográfica. Pelas análises do Ipeafro, estima-se uma nova história do negro no ensino brasileiro, em especial, pelo realce da trajetória e do legado do Abdias Nascimento nas lutas contra o racismo ao longo do século XX expresso nos variados documentos do acervo. Por fim, espera-se contribuir para a divulgação do acervo e servir como aliado para o ensino das histórias e culturas africanas e afro-brasileiras.
تكنولوجيا إجراءات التقاضي وثقة المتقاضين في تطبيقها
Authors: عبدالعالي سعيد 
Published: December 2024

تهدف الدراسة الى القاء الضوء على تأثير التكنولوجيا على التقاضي ، وحيث نحاول عرض ماهية التقاضي الالكتروني ، والتجارب العربية في مجال التقاضي التكنولوجي او الالكتروني أو التقاضي عن بعد، وكذلك نشير الى التجارب العربية في مجال التقاضي الالكتروني ، وخصائص القضاء الرقمي والمحاكم الافتراضية الى جانب عرض اهم التحديات او المعوقات التي قد تواجه التقاضي الالكتروني في الدول العربية.
اعتمدت الدراسة على المنهج التحليلي المقارن لبيان النصوص المتعلقة بالضمانات المتعلقة بحماية المتقاضين في القضاء الالكتروني ، والتعرف على تجارب الدول العربية في مسار القضاء الالكتروني أو القضاء عن بعد.
توصلت الدراسة الى أن التقاضي الالكتروني يساهم في تحسين سرعة العمل في نظام العدالة، حيث يمكن استخدام التكنولوجيا لتسريع اجراءات التقاضي وتنفيذ الأحكام.، ويقلل التكاليف، حيث يمكن استخدام التكنولوجيا لتحسين كفاءة العمل وتقليل الاجراءات الورقية والمتعلقة بالإجراءات الإدارية
كما توصلت الى عدم تفاعل التشريعات النافذة مع التشريعات الحديثة العالمية والقوانين النموذجية التي صدرت عن الامم المتحدة وخاصة التشريعات الارشادية المتعلقة باستخدام الوسائل الالكترونية في المعاملات المدنية والتجارية .
كشف الأسرار عمّا تعرض له جمع الجوامع من الاختصار
Authors: الشلماني أحمد 
Published: December 2024

يتناول هذا البحث قضية ادعاء ابن السبكي تعذّر اختصار كتابه "جمع الجوامع" وتعسّر نقصانه، وأنّه لا يقوم بذلك إلا من كان مبذراً مبتراً، وما هو سبب هذا الادعاء؟ وكيف أقدم زكريا الأنصاري على اختصاره في كتابه "لب الأصول" متجاهلا ًهذا الادعاء؟ ومن أجل الكشف عن هذه القضية فقد تناول البحث تحليل مقدمة وخاتمة هذين الكتابين، للوقوف على حقيقة ادعاء ابن السبكي، ولمعرفة منهج زكريا الأنصاري ومسلكه في عملية الاختصار، ثم تناول البحث دراسة نماذج مختارة من المسائل التي قام زكريا بتبديلها من حيث ذكر المعتمد وتوضيح المبهم وحذف الخلاف والأسماء مع الزيادات التي زادها. ثم تعرّض البحث لذكر بعض ملاحظات العلماء على كتاب "جمع الجوامع"، وتناول خلال ذلك معنى المختصرات والمتون، وختم بذكر ما يمنحه الله تعالى من نعمة العلم والفهم لمن تقدّم من العلماء ولمن تأخّر.
Development of Intelligest Yield Estimation System for Dragon Fruit Orchard Based on Image Processing
Authors: Chaudhari Dnyaneshwar R. , Patil S. B. , Ghatge J. S. , Gore A. M. 
Published: December 2024

Dragon fruit, a tropical fruit renowned for its unique appearance and nutritional value, has gained significant popularity in recent years. The development of an intelligent yield estimation system for dragon fruit orchards can have broader implications for the agricultural industry. It can enable data-driven decision-making, improve supply chain management, and enhance market analysis. The system can also be integrated with existing farm management systems, precision agriculture technologies, and decision support systems to provide a comprehensive solution for farmers. The developed system has utilized advanced sensors and controllers to accurately count the number of fruits, measure their size, and calculate the yield. The detection performance was studied on the basis of accuracy, precision, recall, F1 score, detection accuracy and yield estimation accuracy. The results obtained at different speeds of operation viz. 2 km/h, 3km/h and 4 km/h with different deep learning models viz. SSD, YOLOv2 and YOLOv3. The maximum size detection accuracy using SSD, YOLOv2, and YOLOv3 was 94.16 %, 92.69% and 94.74% respectively, observed at 2 km/h operating speed. The developed yield estimation system can estimate the yield of dragon fruit with an average 93.92 % yield estimation accuracy at 2 km/h operating speed and 70 cm distance of camera from the tree using SSD model.
Preliminary Study on the Rodenticidal Effect of Pong-Pong (Cerbera odollam) Seed Powder against Sprague-Dawley Rats
Authors: Jamin Norzainih Jasmin , Maarof Syahida , Che’ Omar Che’ Ammar Abqari 
Published: December 2024

Aims: Pong-pong (Cerbera odollam) is a poisonous plant species that has potent cardiotoxic effects. In Malaysia, its fruit, referred to as ‘buah tikus’ (rat’s fruit), has been traditionally used as a rodent repellent. This study evaluated the rodenticidal effects of pong-pong seed powder based on acute oral toxicity and palatability under laboratory conditions against Sprague-Dawley albino rat, Rattus norvegicus.
Study Design: The acute oral toxicity test was done according to the Organization for Economic Cooperation and Development (OECD) Guideline 420 and the free choice feeding test was conducted according to Palmateer (1974).
Place and Duration of Study: Animal Laboratory at AMTREC Building, Malaysian Agricultural Research and Development Institute (MARDI) Headquarters, Serdang, Selangor, Malaysia, between May 2023 to May 2024.
Methodology: Pong-pong fully ripe fruits (red colour) were collected from Sekinchan, Sabak Bernam, Selangor. The fruits were sliced into halves for the seeds, cleaned, dried and ground into powder. The seed powder was administered orally by mixing the prescribed dose into the rat food bait. The acute oral toxicity test was done according to the OECD Guideline 420, administering a single high dose of 5 g/kg of body weight. The palatability was determined by using a free choice feeding test between treated bait (mixed with Pong-pong seed powder) with that of the untreated bait.
Results: Results indicated a higher susceptibility in female rats, with 83% mortality compared to 33% in males. Based on the palatability results, the acceptance rate of female rats was 25.6% which is lower compared to 44.2% in males. This implies that the females are more sensitive to the seed powder in the baits and significantly reduce their intake of the treated bait when an alternative food is available.
Conclusion: Although the preliminary findings demonstrated acute oral toxicity of pong-pong seed powder in rats, further research is needed to confirm its efficacy as a rodenticide.
Effect of Weather Parameters on Incidence of Leaf Miner (Lirimomyza trifolii Burgess) Infesting Tomato (Solanum lycopersicum L.)
Authors: D.B. Ingole , B.D. Shinde , P.B. Sanap , M.S. Karmarkar , J.J. Kadam 
Published: December 2024

A field experiment was conducted during the Rabi seasons of 2021-22 and 2022-23 to study the influence of various meteorological parameters on the population dynamics of leaf miner infesting tomato (Solanum lycopersicum L.). The study was carried out at the Central Experiment Station, Wakawali, Dr. Balasaheb Sawant Konkan Krishi Vidyapeeth, Dapoli. During Rabi 2022-23 the leaves were infested by leaf miner, L. trifolli ranged between 12.02 to 41.03 per cent. While in Rabi 2023-24 it ranged from 4.30 to 43.13 per cent. The peak pest infestation was observed during the 8th and 10th SMW in Rabi 2022-23 and Rabi 2023-24, respectively. However, pooled data on both the years revealed that the leaves infestation was in the range of 8.16 to 39.98 per cent and peak was observed during the 9th SMW. During rabi 2022-23 the leaf miner showed a significant negative correlation with evening relative humidity (r=-0.684**), while significant positive correlation with evaporation (r=0.617**). During rabi 2023-24 the pest showed a significant positive correlation with maximum temperature (r=0.0.589*), bright sunshine hours (r=0.600*), wind speed (r=0.935**) and evaporation(r=0.847**), while significant negative correlation with morning relative humidity (r=-0.702**) and evening relative humidity(r=-0.564). The coefficient of determination (R2) indicated that, the weather parameters contributed to 90 per cent in Rabi 2022-23 and 95 per cent in Rabi 2023-24 of total variation in the population of leaf miner on tomato.
Pregnancy Outcomes in Patients With Interstitial Lung Disease
Authors: Clowse Megan E. B. , Rajendran Aardra , Eudy Amanda , Giattino Stephanie , Swaminathan Aparna , James Andra H. 
Published: November 2021

ObjectiveWomen with interstitial lung disease (ILD) are recommended to avoid pregnancy based on limited data. This study seeks to determine maternal and pregnancy outcomes in the largest‐to‐date cohort of patients with ILD.MethodsMedical records in the Duke University Health System were reviewed for pregnancies in patients with a diagnosis of ILD with underlying autoimmune disease. Pregnancies were classified as having very severe, severe, mild‐moderate, or normal lung function based on pulmonary function tests (PFTs). Adverse pregnancy outcomes (APOs) were defined using the Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus and Antiphospholipid Syndrome APO (PROMISSE‐APO) and Severe PROMISSE‐APO criteria.ResultsAmong 86 pregnancies in 60 women, 85% women were Black, 71% had sarcoidosis, and 29% had connective tissue disease (CTD)–associated ILD (CTD‐ILD). Of the pregnancies with available PFTs (n = 59), 12% had very severe ILD, 25% had severe ILD, 51% had mild‐moderate ILD, and 12% had normal lung function.PROMISSE‐APOs occurred in 32% of pregnancies, including all pregnancies with very severe ILD (P = 0.02 across severity groups), 56% of pregnancies with CTD‐ILD, and 23% with sarcoidosis (P = 0.02). Severe PROMISSE‐APOs occurred in 15% of pregnancies, including 60% with very severe ILD and 28% with CTD‐ILD. There were no maternal deaths. One woman required an intensive care hospital stay during pregnancy. Three women had volume overload after delivery that resolved with medical management. Seven women received oxygen during delivery, although none were intubated.ConclusionAlthough APOs were common in women with very severe ILD and underlying CTD, overall maternal morbidity and mortality were low. These data suggest women with ILD may be able to safely attempt pregnancy.
High‐Throughput, Label‐Free and Slide‐Free Histological Imaging by Computational Microscopy and Unsupervised Learning
Authors: Zhang Yan , Kang Lei , Wong Ivy H. M. , Dai Weixing , Li Xiufeng , Chan Ronald C. K. , Hsin Michael K. Y. , Wong Terence T. W. 
Published: November 2021

AbstractRapid and high‐resolution histological imaging with minimal tissue preparation has long been a challenging and yet captivating medical pursuit. Here, the authors propose a promising and transformative histological imaging method, termed computational high‐throughput autofluorescence microscopy by pattern illumination (CHAMP). With the assistance of computational microscopy, CHAMP enables high‐throughput and label‐free imaging of thick and unprocessed tissues with large surface irregularity at an acquisition speed of 10 mm2/10 s with 1.1‐µm lateral resolution. Moreover, the CHAMP image can be transformed into a virtually stained histological image (Deep‐CHAMP) through unsupervised learning within 15 s, where significant cellular features are quantitatively extracted with high accuracy. The versatility of CHAMP is experimentally demonstrated using mouse brain/kidney and human lung tissues prepared with various clinical protocols, which enables a rapid and accurate intraoperative/postoperative pathological examination without tissue processing or staining, demonstrating its great potential as an assistive imaging platform for surgeons and pathologists to provide optimal adjuvant treatment.
π‐Extended Conjugated Polymer Acceptor Containing Thienylene–Vinylene–Thienylene Unit for High‐Performance Thick‐Film All‐Polymer Solar Cells with Superior Long‐Term Stability
Authors: Zhang Jiabin , Tan Ching‐Hong , Zhang Kai , Jia Tao , Cui Yongjie , Deng Wanyuan , Liao Xunfan , Wu Hongbin , Xu Qinghua , Huang Fei , Cao Yong 
Published: November 2021

AbstractDespite the rapid developments in all‐polymer solar cells (all‐PSCs) due to the progress of polymerized small molecular acceptors (PSMA), the effect of linkage unit conjugation on the polymer acceptor (PA) is not well understood and PAs with high efficiency, good stability, and thickness‐insensitivity are rarely seen. Herein, two novel PSMAs, named PJTVT and PJTET are designed, by incorporating conjugated thienylene‐vinylene‐thienylene (TVT) and unconjugated thienylene–ethyl–thienylene (TET) units, respectively. Results show that the energy levels, energy losses, and energy offset of the two PSMAs have little difference (<≈0.03 eV). However, due to the π‐extended coplanar backbone of PJTVT, when blended with polymer donor JD40, a more ordered π–π stacking and enhanced face‐on orientation morphology is observed, which contributes to enhanced exciton dissociation, superior charge transport, and faster charge extraction, leading to a record power conversion efficiency of 16.13% (10.93% for JD40:PJTET). Impressively, the JD40:PJTVT device shows superior thickness‐insensitivity and long‐term stability, both of which make it an ideal choice for industrialization. These results demonstrate that molecular modulation in the linking unit is a promising strategy to construct PSMAs for high‐performance thick‐film all‐PSCs with superior long‐term stability, and shows the superiority of conjugated backbones for PSMAs.
Response of weeds and rice yield to Italian ryegrass as a cover crop and planting density in organic farming
Authors: Matsuoka Takushi , Asagi Naomi , Komatsuzaki Masakazu 
Published: November 2021

AbstractOrganic farming has been receiving increased attention in the agriculture sector; however, Japanese organic farming often requires intensive labor, and the yield is lower compared with the conventional rice (Oryza sativa L.) system. In this study, we examined the effects of planting density (12.7 vs. 24.2 plant m−1) and cover crop (Italian ryegrass [Lolium multiflorum Lam.] vs. winter fallow) on organic rice production in central Japan. A 2‐yr experiment was conducted under organic management in a paddy field at the Center for International Field Agriculture Research & Education, Ibaraki University in 2019 and 2020 using a split‐plot design with four replications. Rice yields were 25 and 6.8% higher when Italian ryegrass was used as the cover crop under sparse planting conditions than under dense planting conditions in 2019 and 2020, respectively. The interaction between cover crop and planting density was significant across the 2 yr. Although there was no significant difference in weed biomass during the rice cultivation period, sparse planting and winter fallow resulted in greater weed biomass than dense planting and Italian ryegrass, respectively. The contribution of nitrogen (N) derived from Italian ryegrass showed a significant difference between 2019 and 2020 but not between sparse and dense planting. Although cover‐crop‐derived N contribution to organic rice production was different between the 2 yr, the use of Italian ryegrass as a cover crop at sparse planting density can improve rice yield and suppress weed growth in central Japan.
Freeze‐dried platelets are a promising alternative in bleeding thrombocytopenic patients with hematological malignancies
Authors: Ohanian Maro , Cancelas Jose A. , Davenport Robertson , Pullarkat Vinod , Hervig Tor , Broome Catherine , Marek Kelly , Kelly Mary , Gul Zartash , Rugg Neeta , Nestheide Shawnagay , Kinne Bridget , Szczepiorkowski Zbigniew , Kantarjian Hagop , Pehta Joan , Biehl Ruth , Yu Anna , Aung Fleur , Antebi Ben , Fitzpatrick Glen Michael 
Published: November 2021

AbstractThrombosomes are trehalose‐stabilized, freeze‐dried group O platelets with a 3‐year shelf life. They can be stockpiled, rapidly reconstituted, and infused regardless of the recipient's blood type. Thrombosomes thus represent a potential alternative platelet transfusion strategy. The present study assessed the safety and potential early signals of efficacy of Thrombosomes in bleeding thrombocytopenic patients. We performed an open‐label, phase 1 study of single doses of allogeneic Thrombosomes at three dose levels in three cohorts, each consisting of eight patients who had hematologic malignancies, thrombocytopenia, and bleeding. Adverse events, dose‐limiting toxicities (DLTs), World Health Organization (WHO) bleeding scores, and hematology values were assessed. No DLTs were reported. The median age was 59 years (24–71). Most patients had AML (58%) or ALL (29%), followed by MDS (8%) and myeloproliferative neoplasm (4%). The WHO scores of 22 patients who were actively bleeding at a total of 27 sites at baseline either improved (n = 17 [63%]) or stabilized (n = 10 [37%]) through day 6. Twenty‐four hours after infusion, 12 patients (50%) had a clinically significant platelet count increase. Of eight patients who received no platelet transfusions for 6 days after Thrombosomes infusion, 5 had a clinically significant increase in platelet count of ≥5000 platelets/μL and 2 had platelet count normalization. Thrombosomes doses up to 3.78 × 108 particles/kg demonstrated safety in 24 bleeding, thrombocytopenic patients with hematological malignancies. Thrombosomes may represent an alternative to conventional platelets to treat bleeding. A phase 2 clinical trial in a similar patient population is underway.
Ultra‐hyper‐fractionated radiotherapy for high‐grade gliomas
Authors: Frosina Guido , Fontana Vincenzo , Verzola Daniela , Rosa Alessandra , Gaggero Gabriele , Garibotto Giacomo , Vagge Stefano , Pigozzi Simona , Daga Antonio 
Published: November 2021

AbstractHigh‐grade gliomas (HGGs; WHO grades III and IV) are invariably lethal brain tumors. Low‐dose hyper‐radiosensitivity (HRS) of HGG is a well‐established phenomenon in vitro. However, possibly linked to the unavailability of accurate animal models of the diseases, this therapeutic effect could not be consistently translated to the animal setting, thus impairing its subsequent clinical development. The purpose of this study was to develop radiotherapeutic (RT) schedules permitting to significantly improve the overall survival of faithful animal models of HGG that have been recently made available. We used primary glioma initiating cell (GIC)‐driven orthotopic animal models that accurately recapitulate the heterogeneity and growth patterns of the patients' tumors, to investigate the therapeutic effects of low radiation doses toward HGG. With the same total dose, RT fractions ≤0.5 Gy twice per week [ultra‐hyper‐fractionation (ultra‐hyper‐FRT)] started at early stages of tumor progression (a condition that in the clinical setting often occurs at the end of the guidelines treatment) improved the effectiveness of RT and the animal survival in comparison to standard fractions. For the same cumulative dose, the use of fractions ≤0.5 Gy may permit to escape one or more tumor resistance mechanisms thus increasing the effectiveness of RT and the overall animal survival. These findings suggest investigating in the clinical setting the therapeutic effect of an ultra‐hyper‐FRT schedule promptly extending the conventional RT component of the current guideline (“Stupp”) therapeutic protocol.