bluuebunny/crossref_metadata_2025_split huggingface dataset:
Designing and pilot testing a novel high-definition transcranial burst electrostimulation device for neurorehabilitation
Authors: Wang Shun-Min Samuel , Huang Yi-Jing , Chen Jia-Jin Jason , Wu Chun-Wei , Chen Chien-An , Lin Che-Wei , Nguyen Van-Truong , Peng Chih-Wei 
Published: September 2021

AbstractObjective.Non-invasive brain stimulation has been promoted to facilitate neuromodulation in treating neurological diseases. Recently, high-definition (HD) transcranial electrical stimulation and a novel electrical waveform combining a direct current (DC) and theta burst stimulation (TBS)-like protocol were proposed and demonstrated high potential to enhance neuroplastic effects in a more-efficient manner. In this study, we designed a novel HD transcranial burst electrostimulation device and to preliminarily examined its therapeutic potential in neurorehabilitation.Approach.A prototype of the transcranial burst electrostimulation device was developed, which can flexibly output a waveform that combined a DC and TBS-like protocol and can equally distribute the current into 4 × 1 HD electrical stimulation by automatic impedance adjustments. The safety and accuracy of the device were then validated in a series ofin vitroexperiments. Finally, a pilot clinical trial was conducted to assess its clinical safety and therapeutic potential on upper-extremity rehabilitation in six patients with chronic stroke, where patients received either active or sham HD transcranial burst electrostimulation combined with occupational therapy three times per week for four weeks.Main results.The prototype was tested, and it was found to comply with all safety requirements. The output parameters were accurate and met the clinical study needs. The pilot clinical study demonstrated that the active HD transcranial burst electrostimulation group had greater improvement in voluntary motor function and coordination of the upper extremity than the sham control group. Additionally, no severe adverse events were noted, but slight skin redness under the stimulus electrode immediately after stimulation was seen.Conclusions.The results demonstrated the feasibility of incorporating the HD electrical DC and TBS-like protocol in our device; and the novel neuromodulatory device produced positive neurorehabilitation outcomes in a safe fashion, which could be the basis for the future clinical implementation for treating neurological diseases.Trial registration:ClinicalTrials.gov Identifier: NCT04278105. Registered on 20 February 2020.
Spatial distribution of bottom sediments of the near-dam ples of Kuibyshev Reservoir
Authors: Turutina T V , Rakhuba A V , Shmakova M V 
Published: September 2021

Abstract
The composition of bottom sediments and the patterns of their spatial distribution are determined by external (type of underlying surface of the catchment area, anthropogenic development, intensity of soil erosion) and internal (water regime, intensity of water exchange, morphometry of the basin) factors. The analysis of the granulometric composition of the bottom sediments of the near-dam ples of the Kuibyshev Reservoir showed the relative uniformity of the ples soil in terms of size. At the same time, depending on the location of the sampling points, certain patterns of distribution of the size of bottom sediments in space are traced.
Kuibyshev reservoir shore transformation as a factor of archaeological heritage objects destruction
Authors: Gainullin I I , Usmanov B M , Sharipova D R , Bagautdinova L N 
Published: September 2021

Abstract
The article presents the results of long-term research carried out in the shoreline zone of the Kuibyshev reservoir, at the location of the Izmer’s complex of multitemporal archeological sites, territory the Republic of Tatarstan. “Beganchik” Paleolithic site and fortified settlement of Bolgar period “Devichiy Gorodok” were selected for detailed study. The assessment of the shoreline transformation has been carried out with the use of remote sensing data, advanced methods of field survey and geoinformation analysis. As a result the most dynamic areas have been identified. In the work, were used archival aerial images, high-resolution satellite images and results of field surveys.
The structure of currents and water exchange in the overgrowing shallows
Authors: Poddubnyi S A , Kutuzov A V , Tsvetkov A I 
Published: September 2021

Abstract
The morphometric characteristics and bottom topography of typical shallows behind the island are characterized. The long – term and seasonal dynamics of the water level in the Rybinsk reservoir during the period from 1947 to 2020 is considered. The periods of fluctuations of the main hydrometeorological parameters in relation to the investigated section of the reservoir are shown. Based on archival and modern observation data on the structure of currents, the patterns of water transport and water exchange in the shallows are investigated, taking its seasonal overgrowth with macrophytes into account.
Influence of post-pyrogenic successions of the forests of the Urals on the formation of maximum rainfall flood discharges
Authors: Ye Klimenko D , Cherepanova E S , Khomyleva A A 
Published: September 2021

Abstract
The issues of losses on the crowns of forest stands in the conditions of forest successions after fires and associated changes in the maximum discharge of rainfall floods are considered. The results of complex field, experimental work, deterministic modelling are presented. It has been established that with the complete burnout of forests in the catchment, the maximum flow rates can increase by 40% compared to the initial state of the forests, and with the restoration of forests, the maximum flow rates of floods again decrease by 15-20% over a 20-year period.
Assessment of the Kuybyshev Reservoir bed state: a case study
Authors: Khomyakov P V , Usmanov B M 
Published: September 2021

Abstract
The generalized results of the Kuybyshev Reservoir bed relief survey using modern methods are presented on the example of two sites. Sakony site area is located on the low left bank of the Kuybyshev Reservoir in the place of sand and gravel mix extraction, Sviyazhsk site – around the cultural heritage object Sviyazhsk island-town. The change in the bottom topography was monitored using the Interferometric Side-Scan Sonar and the HyScan software. Bathymetric maps and transverse profiles for study sites were built. A description of the bottom relief in the studied areas is given. As a result, reservoir bottom survey technique was developed to update its morphometry, possibility of obtained data application is discussed.
Flow rate regime of the Western Urals’s rivers
Authors: Mikova K D , Managadze A K 
Published: September 2021

Abstract
The flow rate is one of the most important elements of the river’s water regime. Establishing patterns in river flow rates’ changes within a year and by season is of great importance for the hydrological forecasts for spring floods, rain floods and hydrological calculations. By now, there are few publications on this area, both in Russia and abroad. The initial data were divided into 5 hydrological seasons – winter and summer low water, rise and fall of spring floods and autumn rain floods. For each season, an analysis of river flow rate over a period (1936-2013) was done. The average flow rate in rivers varied greatly depending on the water regime’ phase and the type of terrain in which the river flows. For all seasons, the amplitude of fluctuations in the flow rate on the plain rivers is less than on the mountain ones. So, in mountain rivers, flow rates vary from 0.04 to 2.42 m/s, and on flat rivers from 0.02 to 1.43 m/s. As well the pairwise and multiple correlation coefficients of flow rates for each morphometric and catchment characteristics were calculated. The highest correlation coefficients were obtained for the dependency between the average flow rate and the watershed elevation (0.30-0.75) and the watershed slope (0.42-0.76). The multiple correlation coefficients between the average flow rate and all catchment’s morphometric characteristics varied from 0.97 to 0.99. Results verification on an independent data demonstrated that the relative error was on average 2%.
Assessment of the landslide process intensity on the bank of the Kuybyshev Reservoir using instrumental methods
Authors: Gafurov A M , Usmanov B M , Yermolayev O P 
Published: September 2021

Abstract
The aim of the work was to survey and monitor dangerous exogeodynamic processes on the shoreline of the Kuibyshev reservoir. Field instrumental studies were used as the main method, including topo-geodetic survey of key morphological elements of the slope with ground control points, video and photo recording of the processes. Since 2019, unmanned aerial vehicle surveys have been chosen as the main method of research. The paper presents the results of long-term studies of the local landslide near Tetyushi, Republic of Tatarstan. As a result of 2003-2006 situational plans processing and results of UAV survey in 2019 quantitative data on the intensity of slope processes in the mass landslide were obtained.
Urban impact on water quality in the rivers of Central Russia
Authors: Georgiadi A G , Sharapova E O , Danilenko A O 
Published: September 2021

Abstract
Comparative analysis of the urban impact on water quality in the main rivers of Central Russia has been performed based on hydrochemical observations dataset for the period 2005-2019. It was obtained from monitoring results at the gauging stations located upstream and downstream of 11 cities in the studied region. The pollution level was estimated by comparison of the annually-averaged concentration values for 43 water quality indicators with their defined maximum permissible concentrations. The most substantial growth in concentrations downstream of the cities compared to their upstream values was revealed for heavy metals, nitrogen compounds, phosphates and oil products. A much less significant negative impact was imposed by cities on transparency, oxygen and major ions content. The cities were ranked by the total number of hydrochemical indicators which concentrations 1) increase downstream of cities, 2) exceed the maximum permissible concentrations before and after entering cities, 3) exceed the maximum permissible concentration before and after entering cities while sufficiently increasing (> 10%) at the downstream station. Additionally, the indicators were identified that experienced the most considerable impact from the urban areas. Among the studied cities, three groups were identified differing from each other in the degree of impact on the river water quality.
Mathematical modelling of spatial-temporal variability of phosphorus content and phytoplankton development in the Kuibyshev reservoir
Authors: Rakhuba A V 
Published: September 2021

Abstract
The article is dedicated to simulation of phytoplankton biomass growth dynamics amidst flow control in one of the biggest flowing water reservoirs in the world – the Kuybyshev Reservoir. Uniqueness of this natural-technical water body with such large area is pre-defined by significant spatiotemporal changes in physical, chemical and biological parameters, specifying quality and ecological condition of aquatic environment. Studies are conducted using materials of full-scale hydro-ecological observations in the reservoir within vegetation period, in 2016. Some simulation exercises were performed on the model. The model is developed based on hydro-thermodynamics equations and empirical dependences of phosphorous limitation of phytoplanktonic community biomass growth, which is implemented in VOLNA authorial software envelope. The calculation was performed on rectangular spatial grid with spacing of 200 m and timed discretization of 1 day. Within full-scale observations, initial information is acquired, model parameters are calibrated and quality of performed calculations is assessed. Simulation modelling of seasonal phytoplankton field dynamics in Kuybyshev reservoir were analysed using 2D-model of phyto-phosphorous system and results were represented. According to calculations data, phytoplankton biomass growth along reservoir length from headstream to Zhigulevsk HPP dam is observed, as well as intense water blooming locations were detected in estuarial areas and shallow-water parts of the reservoir.
Principal characteristics of transformations in hydrological and ecological conditions of minor rivers within the affected area of mining facilities (on the example of the rivers Karagayly and Khudolaz in the Ural river basin)
Authors: Gareev A M , Belan L N , Goryachev V S , Farkhutdinov A M , Baryshev V I , Shevchenko A M , Ostrovskaya Yu V , Gainanshin M F 
Published: September 2021

Abstract
The article reveals the specific features of the influence posed by mining facilities towards morphometric and hydrological characteristics as well as the environmental condition of small rivers. Given the characteristic features of the impact experienced by the environment (incl. water bodies), the article seeks to identify the peculiarities of the influence caused by a large set of industries involved in the extraction of minerals and their primary treatment leading to production of semi-finished products of non-ferrous metallurgy. The objects of investigation cover the rivers Karagayly and Khudolaz, which are located within the upper reaches of the river Ural and are undergoing an excessively high impact caused by the facilities of the latter industry and the housing and public utilities.
Hydrochemistry of the rivers of the Kama basin in the Northern and Middle Urals
Authors: Kazantseva A S , Kadebskaya O I 
Published: September 2021

Abstract
The hydrochemical indicators of four rivers of the Kama basin (Kolva, Sylva, Shakva and Kishertka), flowing in the territory of the Northern and Middle Urals within the Perm region, have been analysed. It is shown that the river waters of both regions are characterized by common feeding conditions. The data of macro- and microelement analysis made it possible to carry out a modern assessment of the quality of river runoff, as well as to carry out a comparative analysis of the hydrochemical parameters of the waters of the surface runoff of two geographical regions.
The role of the Kama river system in regional development
Authors: Balina T A , Nikolaev R S , Stolbov V A , Yu Chekmeneva L 
Published: September 2021

Abstract
The role and functions of the Kama river system as a natural basis for the socio-economic development of Perm Region are considered. The competitive advantages of the Kama region in the context of the development of the transport and logistics system, energy production, fisheries and aquaculture, tourism and recreation are identified. Special attention is paid to the problems of interaction of the leading industries of Perm Region with the Kama river system. The main directions of involvement of the river system in the national economic complex of the region in the new market conditions are shown. The necessity of positioning Kama as a brand of the Perm Region is justified.
Construction of a model of nutrient export from the catchment using GIS-technologies for a transboundary river in Russia and Finland
Authors: Korobchenkova K D , Ershova A A 
Published: September 2021

Abstract
GIS model SWAT to assess the nutrient load on the catchment area of the Gulf of Finland from the transboundary Seleznevka River (Rakkolanjoki) was applied. All stages of the model setup are considered: preparation of initial data, building the SWAT-model, its calibration and scenario calculations. We consider the possibility of using the SWAT-model for managing the quality of water bodies in Russia and the difficulties that arise while building a model for this catchment area.
Assessment of the anaerobic microbial potential for the bioremediation of gas condensate-contaminated groundwater
Authors: Maksimovich N G , Khmurchik V T , Demenev A D , Yu Meshcheryakova O 
Published: September 2021

AbstractThe gas condensate leakage incident took place in Bashkortostan (Russian Federation), which caused soil and groundwater pollution with hydrocarbons. After the incident, the emergency plan was started and kinds of measures were carried out immediately. But the residual subsurface source of pollution within ground is still present and contaminates groundwater. We investigated the capability of ground’s indigenous microbial community to degrade gas condensate hydrocarbons under anaerobic conditions. The enrichment microbial cultures of nitrate reducers, ferric reducers, sulphate reducers and methanogens, capable to degrade gas condensate hydrocarbons, were isolated at incident site from polluted ground. All cultures demonstrated the ability to degrade hydrocarbons under laboratory conditions. The enrichment culture of nitrate reducers was chosen as the most appropriated one to biotechnological applicationin situ(i.e. at incident site) — it held the capability to degrade gas condensate hydrocarbons after three consecutive aerobic incubations in the rich medium (meat-peptone broth) amended with glucose. To our mind, biomass of this culture being readily and quickly grown in aerobic conditions on cheap organic media could be directly used to remediate gas condensate-polluted groundwater and groundin situ.
Anthropogenic eutrophication of lakes Turgoyak and Bolshoi Kisegach
Authors: Zakharov S G 
Published: September 2021

Abstract
The article examines the long-term dynamics of three main indicators of the trophic state of water bodies (transparency, phosphorus concentration and oxygen regime) for the natural oligotrophic lakes of the Southern Urals: Turgoyak and Bolshoi Kisegach. These lakes have a similar history of anthropogenic development (water intake and recreation). At the same time, the lakes have a different degree of anthropogenic transformation in connection with different volumes of incoming nutrients, which affect the quality of lake waters and natural recreational potential.
Assessing the sustainable development of an enterprise from the water use standpoint
Authors: Dvinskikh S A , Larchenko O V , Oskina M A 
Published: September 2021

Abstract
The role of industrial enterprises in ensuring a sustainable development project are analysed. It shows that when planning their work, the companies should take into account not only their economic performance, but also the state of the environment. It is the negative consequences of production that have a destructive effect on the environment, including water resources. To assess the state of water resources, which is shaped by the work of enterprises, it is proposed to use indicators and indices. The study gives an overview of the existing assessment methods, as well as proposes custom ones.
Phytoplankton of unique karst lakes (by the example of the Lake Klyuchik, the basin of the Cheboksary Reservoir)
Authors: Startseva N A , Vodeneeva E L , Kulizin P V , Sharagina E M , Zolotova M V , Okhapkin A G 
Published: September 2021

Abstract
The features of the composition, development and spatial distribution of phytoplankton of a small highly mineralized karst low-temperature lake (Lake Klyuchik or Svyatoe Doskinskoe, Nizhny Novgorod Region) with atypically high for the forest zone (subzone of mixed coniferous and broad-leaved forests) values of water salinity are considered. The lake is characterized by an expressed ecotone in terms of hydrological and hydrochemical indicators.
Mycrocystin-LR degradation by indigenous bacterial community of Rybinsk Reservoir
Authors: Medvedeva N G , Kuzikova I L 
Published: September 2021

Abstract
The fate of microcystin-LR (MC-LR) in water samples of Rybinsk Reservoir taken before and during water bloom was assessed. The decrease in the MC-LR concentration in the both samples was due to its biodegradation by indigenous bacterial community. The highest biodegradation rate and shortest half-life of MC-LR in the water sample taken during water bloom were observed. A microcystin degrading bacterium was isolated and shown be 98.92% similar to Sphingopyxis sp. based on a fragment of 16S rRNA gene sequence. The rate of MC-LR biodegradation by Sphingopyxis sp. S7 was strongly dependent on initial concentration of toxin and temperature.
PLX3397, a CSF1 receptor inhibitor, limits allotransplantation-induced vascular remodelling
Authors: Almonte Vanessa M , Uriyanghai Unimunkh , Egaña-Gorroño Lander , Parikh Dippal , Oliveira-Paula Gustavo H , Zhang Jinghang , Jayakumar Smitha , Riascos-Bernal Dario F , Sibinga Nicholas E S 
Published: September 2021

Abstract

Aims
Graft vascular disease (GVD), a clinically important and highly complex vascular occlusive disease, arises from the interplay of multiple cellular and molecular pathways. While occlusive intimal lesions are composed predominantly of smooth-muscle-like cells (SMLCs), the origin of these cells and the stimuli leading to their accumulation in GVD are uncertain. Macrophages have recently been identified as both potential drivers of intimal hyperplasia and precursors that undergo transdifferentiation to become SMLCs in non-transplant settings. Colony-stimulating factor-1 (CSF1) is a well-known regulator of macrophage development and differentiation, and prior preclinical studies have shown that lack of CSF1 limits GVD. We sought to identify the origins of SMLCs and of cells expressing the CSF1 receptor (CSF1R) in GVD, and to test the hypothesis that pharmacologic inhibition of CSF1 signalling would curtail both macrophage and SMLC activities and decrease vascular occlusion.

Methods and results
We used genetically modified mice and a vascular transplant model with minor antigen mismatch to assess cell origins. We found that neointimal SMLCs derive from both donor and recipient, and that transdifferentiation of macrophages to SMLC phenotype is minimal in this model. Cells expressing CSF1R in grafts were identified as recipient-derived myeloid cells of Cx3cr1 lineage, and these cells rarely expressed smooth muscle marker proteins. Blockade of CSF1R activity using the tyrosine kinase inhibitor PLX3397 limited the expression of genes associated with innate immunity and decreased levels of circulating monocytes and intimal macrophages. Importantly, PLX3397 attenuated the development of GVD in arterial allografts.

Conclusion
These studies provide proof of concept for pharmacologic inhibition of the CSF1/CSF1R signalling pathway as a therapeutic strategy in GVD. Further preclinical testing of this pathway in GVD is warranted.
Structural recognition of the mRNA 3′ UTR by PUF-8 restricts the lifespan of C. elegans
Authors: Xu Zheng , Zhao Jie , Hong Minjie , Zeng Chenming , Guang Shouhong , Shi Yunyu 
Published: September 2021

Abstract
The molecular mechanisms of aging are unsolved fundamental biological questions. Caenorhabditis elegans is an ideal model organism for investigating aging. PUF-8, a PUF (Pumilio and FBF) protein in C. elegans, is crucial for germline development through binding with the 3′ untranslated regions (3′ UTR) in the target mRNAs. Recently, PUF-8 was reported to alter mitochondrial dynamics and mitophagy by regulating MFF-1, a mitochondrial fission factor, and subsequently regulated longevity. Here, we determined the crystal structure of the PUF domain of PUF-8 with an RNA substrate. Mutagenesis experiments were performed to alter PUF-8 recognition of its target mRNAs. Those mutations reduced the fertility and extended the lifespan of C. elegans. Deep sequencing of total mRNAs from wild-type and puf-8 mutant worms as well as in vivo RNA Crosslinking and Immunoprecipitation (CLIP) experiments identified six PUF-8 regulated genes, which contain at least one PUF-binding element (PBE) at the 3′ UTR. One of the six genes, pqm-1, is crucial for lipid storage and aging process. Knockdown of pqm-1 could revert the lifespan extension of puf-8 mutant animals. We conclude that PUF-8 regulate the lifespan of C. elegans may not only via MFF but also via modulating pqm-1-related pathways.