bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE CONNECTION BETWEEN ORAL HEALTH AND COVID-19 SEVERITY
Authors: Gedam Unnati , Jain Deshraj , Varma Amit 
Published: May 2021

“Oral health is a reflection of the physiological, social, and psychological factors that are essential to our quality of life”. COVID -19 is becoming a threat all over the world. Obesity, diabetes, and hypertension are common underlying conditions in patients that develop serious COVID-19 complications. In the meantime, evidence of a correlation between oral health and severity of COVID-19 disease is growing, According to various studies, the particular ingredient in some affordable and readily available mouthwash products is highly effective at inactivating the SARS-CoV-2 virus, which causes COVID-19. Simple oral hygiene measures may help reduce the risk of the novel coronavirus spreading from the mouth to the lungs, as well as prevent serious COVID-19 infections. This article briefly reports the importance of oral hygiene and its link with COVID-19 severity.
Keywords: COVID-19, Oral health, severity, global pandemic
Faculty in Contemporary Kyrgyzstan: Reactions to Reforms
Authors: Merrill Martha , Baitugolova Janara , Ryskulova Chynarkul 
Published: May 2021

After Kyrgyzstan’s independence, reforms were implemented in higher education: new degrees, credit hours, private institutions, tuition in public institutions, and independent accreditation. However, faculty reactions to these reforms have not previously been studied. The authors conducted 57 interviews in four locations over three years. Our findings show that, first, interviewees discussed all kinds of changes in higher education and society. Second, participants were undergoing “concurrent stresses” (Anderson, Goodman, and Schlossberg, 2012) – their personal as well as professional lives were changing. Third, opinions differed. We analyzed these according to three of Schlossberg’s “4 S’s”: differences in faculty selves, situations, and support systems. However, few participants described strategies for dealing with the changes. Fourth, nearly all spoke of the reforms as something not under their control. Fifth, very few faculty members described the changes as unilaterally negative or positive. Most said, “I like this, but not that.”
IMAJINER RUANG KEPALA DALAM REKAMAN GAMELAN AGÊNG DENGAN TEKNIK STEREOFONIK
Authors: Santosa Iwan Budi 
Published: May 2021

ABSTRACT The presentation of Javanese gamelan cannot always be present in the midst of our busy lives. In order to present musical karawitan whenever needed by the audience, it requires the recording of Javanese gamelan that can represent the original sound. Javanese people generally realize that the presentation of Javanese gamelan will be better if it is presented in pendapa. To find musical recordings as a performance in pendapa, it needs to consider the recording equipment used as well as recording techniques so that the sound will be obtained in accordance to the original sound and can bring the soul or spirit of Javanese gamelan. In order to get the gamelan recording in accordance to the original sound and to present the soul or spirit of the gamelan, the recording equipment used must adjust to the sound characteristics of the gamelan instruments and the recording uses stereophonic techniques. Stereophonics is a recording technique that is done in order to produce sounds in according to the original sound where the listeners feel to see a live performance. Keywords: Javanese Gamelan, recording, stereophonic. AbastrakPenyajian gamelan Jawa tidak selalu bisa hadir di tengah kesibukan kita. Untuk menyajikan musik karawitan setiap kali dibutuhkan oleh penikmatnya, diperlukan rekaman gamelan Jawa yang dapat merepresentasikan suara aslinya. Masyarakat Jawa umumnya menyadari bahwa penyajian gamelan jawa akan lebih baik jika disajikan dalam pendapa. Untuk mengetahui rekaman musik sebagai sebuah pertunjukan dalam pendapa perlu memperhatikan alat perekam yang digunakan serta teknik perekamannya agar didapat suara yang sesuai dengan suara aslinya dan dapat memunculkan jiwa atau ruh gamelan Jawa. Untuk mendapatkan rekaman gamelan yang sesuai dengan suara aslinya dan menghadirkan jiwa atau ruh dari gamelan tersebut, alat perekam yang digunakan harus menyesuaikan dengan karakteristik bunyi dari alat musik gamelan tersebut dan perekamannya menggunakan teknik stereofonik. Stereophonics adalah teknik perekaman yang dilakukan untuk menghasilkan suara yang sesuai dengan suara aslinya dimana pendengar merasakan secara langsung pertunjukannya. Kata kunci: Gamelan Jawa, rekaman, stereofonik.
ESTETIKA KERAMIK KLASIK DAN KONTEMPORER
Authors: Yustana Prima 
Published: May 2021

ABSTRACT The terms classic and contemporary in this study are interpreted as products that still survive to this day in the form of both classic and contemporary ceramic works or ceramic works today. This researh is a qualitative research using the Aesthetic approach, so that several problems will emerge that must be solved by the method, first, what is meant by Classic and Contemporary ceramics, the second How to Aesthetic Classic and Contemporary Ceramics. The third problem is how the visual form of classical and contemporary ceramics that exist today. The beauty of ceramics can be seen from various perspectives, in this research will also be examined through a variety of written data to increase the validity of the data so that it can provide a good conclusion. Ceramic works are works of art that are very rich in technique, so this research also examines how the relationship between formation techniques and the aesthetics of ceramic works. Keywords: Ceramics, Aesthetics, Classic, Contemporary ABTRAK Istilah klasik dan kontemporer dalam penelitian ini dimaknai sebagai produk yang masih bertahan hingga saat ini baik berupa karya keramik klasik maupun kontemporer atau karya keramik saat ini. Penelitian ini merupakan penelitian kualitatif dengan menggunakan pendekatan Estetika, sehingga akan muncul beberapa permasalahan yang harus diselesaikan dengan metode tersebut, pertama yang dimaksud dengan Keramik Klasik dan Kontemporer, yang kedua Cara Estetika Keramik Klasik dan Kontemporer. Masalah ketiga adalah bagaimana bentuk visual keramik klasik dan kontemporer yang ada saat ini. Keindahan keramik dapat dilihat dari berbagai sudut pandang, dalam penelitian ini juga akan dikaji melalui berbagai macam data tertulis untuk meningkatkan keabsahan datanya sehingga dapat memberikan kesimpulan yang baik. Karya keramik merupakan karya seni yang sangat kaya akan teknik, maka penelitian ini juga mengkaji bagaimana hubungan teknik bentukan dengan estetika karya keramik.Kata Kunci: keramik, estetika, klasik, kontemporer
LANA GENDHING KETHUK 4 KEREP MINGGAH 8 KAJIAN GARAP GENDÈR
Authors: Emhar Atmaja Dita , Boediono Hadi 
Published: May 2021

Skripsi karya seni berjudul Lana Gendhing kethuk 4 kerep minggah 8: Kajian Garap Gender ini disusun untuk menjelaskan kajian gendèran Gendhing Lana. Pada umumnya Gendhing Lana disajikan dalam laras sléndro pathet nem dengan garap inggah kendhang irama dadi. Dalam skripsi karya seni ini Gendhing Lana disajikan dengan berbagai inovasi garap dalam tradisi karawitan gaya Surakarta yang sudah ada, diantaranya adalah: alih laras, mandheg, garap ciblon irama wiled, dan rangkep. Kajian dalam skripsi karya seni ini adalah analisis gendèran yang meliputi tafsir céngkok dan wiledan. Penelitian karya seni ini merupakan penelitian kualitatif. Metode penelitian yang digunakan adalah studi pustaka, observasi, dan wawancara. Sementara menyajiannya penulis menggunakan beberapa konsep garap, alih laras, pathet, dan mandheg. Hasil dari alih laras dalam sajian Gendhing Lana, gendhing kethuk 4 kerep minggah 8 merubah karakter dan rasa gending tersebut. Dalam proses alih laras muncul beberapa penawaran garap baru diantaranya adalah garap ciblon wiled, rangkep, dan mandheg. Dari eksperimen yang dilakukan, jika disajikan dalam laras sléndro pathet nem karakter dan rasa Gendhing Lana adalah regu, anteb, dan wibawa, sementara jika dialih laras ke laras pélog pathet nem karakter dan rasa berubah menjadi bérag, prenes, dan gagah.
Upaya Mendorong Pembelajaran Efektif Masa Pandemi Melalui Pelatihan Inovasi Belajar Berbasis Digital
Authors: Marpaung Zailani Surya , Widodo Slamet , Semil Nurmah , Mardianto Mardianto 
Published: May 2021

Abstract: Pandemic Covid-19 has had a direct impact on the world of education. The limitation of the crowd in community activities in public places causes the world of education to maximize the use of information and communication technology as a medium for distance learning or online. This encourages educators/ teachers to formulate alternatives for distance learning media by adapting them according to the conditions of available facilities and infrastructure, and mastering the use of a number of digital platforms that can be used as alternative learning media. This digital-based learning innovation training activity aims to introduce and assist the use of several digital learning media in one of the schools, namely SMK Lingua Prima Indralaya. Assessment of the success of the training held was carried out through a pretest and post-test. Assistance is carried out so that teachers understand and gain insight in formulating innovative learning methods in the implementation of the distance or online teaching and learning process. In this training, introduction and assistance were carried out related to the use of audio podcasts, maximizing the function of social media and also designing materials with attractive and innovative PowerPoint templates.Keywords: digital based learning; effective learning; pandemic period Abstrak: Pandemi Covid-19 telah berdampak secara langsung terhadap dunia pendidikan. Dibatasinya kerumunan dalam aktivitas masyarakat ditempat umum menyebabkan dunia pendidikan harus memaksimalkan penggunaan teknologi informasi dan komunikasi sebagai media pembelajaran jarak jauh atau daring. Hal ini mendorong tenaga pendidik / guru harus merumuskan alternatif-alternatif media pembelajaran jarak jauh dengan cara mengadaptasinya sesuai dengan kondisi sarana dan prasarana yang tersedia, serta menguasai penggunaan sejumlah platform digital yang dapat digunakan sebagai media pembelajaran alternatif. Kegiatan pelatihan inovasi belajar berbasis digital ini bertujuan untuk melakukan pengenalan dan pendampingan penggunaan beberapa media pembelajaran digital di salah satu sekolah, yakni SMK Lingua Prima Indralaya. Penilaian terhadap keberhasilan pelatihan yang diselenggarakan ini dilakukan melalui pretest dan post-test. Pendampingan dilakukan agar para guru memahami dan menambah wawasan dalam merumuskan metode pembelajaran yang inovatif dalam pelaksanaan proses belajar mengajar jarak jauh atau daring. Pada pelatihan ini dilakukan pengenalan dan pendampingan terkait penggunaan podcast audio, memaksimalkan fungsi media sosial dan juga merancang materi dengan template powerpoint yang menarik dan inovatif.Kata Kunci: masa pandemi; pembelajaran berbasis digital; pembelajaran efektif
Potencial antibacteriano (in vitro) do extrato metanólico da Annona muricata L.
Authors: Batista Anny Karoline Rodrigues , Cesar Kellyane Karen Ferreira Aguiar , Paula Luciana Rocha , Silva Francisco Laurindo da , Raposo Haysha Laianne Oliveira 
Published: May 2021

A resistência bacteriana a antibióticos tornou-se mundialmente um sério problema de Saúde Pública atingindo milhares de pessoas. Assim, vê-se a necessidade de buscar formas alternativas no combate das mesmas. Portanto, essa pesquisa objetivou verificar o efeito antimicrobiano do extrato da Annona muricata L. frente a cepas ATCC de Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa e Staphylococcus aureus. Realizou-se a coleta do material e a obtenção dos extratos, posteriormente houve a preparação das cepas bacterianas para os testes de suscetibilidade. Os testes prosseguiram em três etapas: extratos brutos, extratos fracionados quimicamente e testes com diluições seriadas. Verificou-se atividade antibacteriana da graviola frente a todas as cepas testas sendo o resultado mais significante referente ao extrato bruto do fruto frente a cepa da E. coli com halo igual a 22mm. Em relação aos testes com os extratos já purificados, as frações provenientes do fruto tiverem ação mais relevantes. A fração de Hexano correspondeu em resultados mais expressivos obtendo halos igual a 28mm, 26mm e 37mm frente as cepas de E. coli, K. pneumoniae, e S. aureus respectivamente. Quanto aos testes relacionados as diluições seriadas observamos que a partir da diluição de 1/10 os extratos já não possuíram nenhuma atividade inibitória sobre as bactérias em estudo. Contudo, esses resultados demonstram o potencial do extrato da graviola, em especial do fruto, como fonte de compostos antibacterianos. No entanto, é válido continuar pesquisas mais avançadas com a Annona muricata.
Altered Spontaneous Brain Activity in Women During Menopause Transition and Its Association With Cognitive Function and Serum Estradiol Level
Authors: He Lemin , Guo Wei , Qiu Jianfeng , An Xingwei , Lu Weizhao 
Published: May 2021

ObjectiveSerum hormone deficiencies during menopause transition may affect spontaneous brain activity and global cognition. The purpose of this study was to explore the differences in spontaneous brain activity between premenopausal and perimenopausal women, and to investigate the associations between spontaneous brain activity, serum hormone levels and global cognition.MethodsThirty-two premenopausal women (47.75 ± 1.55 years) and twenty-five perimenopausal women (51.60 ± 1.63 years) underwent resting-state functional MRI (fMRI) scan. Clinical information including Mini-Mental State Examination (MMSE), levels of estradiol (E2), free testosterone, progesterone, prolactin, follicle-stimulating hormone and luteinizing hormone were measured. Regional homogeneity (ReHo) was used to evaluate spontaneous brain activity alterations between perimenopausal and premenopausal women. Correlation analysis was used to investigate the associations between brain functional alterations and clinical measures in perimenopausal group.ResultsThe results demonstrated increased ReHo value in the right lingual gyrus (LG) and decreased ReHo value in the right superior frontal gyrus (SFG) in perimenopausal women compared with premenopausal women. In perimenopausal group, ReHo of the right LG showed a negative correlation with level of E2 (r = -0.586, p = 0.002), ReHo of the right SFG showed a positive correlation with level of E2 (r = 0.470, p = 0.018) and MMSE (r = 0.614, p = 0.001).ConclusionsThe results demonstrated that women approaching menopause suffered from altered functions in brain regions related to cognitive function, working memory, the results also revealed a direct association between levels of E2 and brain functions in perimenopausal women.
Synacthen Stimulation Test Following Unilateral Adrenalectomy Needs to Be Interpreted With Caution
Authors: Zaman Shamaila , Almazrouei Raya , Sam Amir H. , DiMarco Aimee N. , Todd Jeannie F. , Palazzo Fausto F. , Tan Tricia , Dhillo Waljit S. , Meeran Karim , Wernig Florian 
Published: May 2021

BackgroundCortisol levels in response to stress are highly variable. Baseline and stimulated cortisol levels are commonly used to determine adrenal function following unilateral adrenalectomy. We report the results of synacthen stimulation testing following unilateral adrenalectomy in a tertiary referral center.MethodsData were collected retrospectively for 36 patients who underwent synacthen stimulation testing one day post unilateral adrenalectomy. None of the patients had clinical signs of hypercortisolism preoperatively. No patient received pre- or intraoperative steroids. Patients with overt Cushing’s syndrome were excluded.ResultsThe median age was 58 (31-79) years. Preoperatively, 16 (44%) patients had a diagnosis of pheochromocytoma, 12 (33%) patients had primary aldosteronism and 8 (22%) patients had non-functioning adenomas with indeterminate/atypical imaging characteristics necessitating surgery. Preoperative overnight dexamethasone suppression test results revealed that 6 of 29 patients failed to suppress cortisol to &lt;50 nmol/L. Twenty (56%) patients achieved a stimulated cortisol ≥450 nmol/L at 30 minutes and 28 (78%) at 60 minutes. None of the patients developed clinical adrenal insufficiency necessitating steroid replacement.ConclusionsSynacthen stimulation testing following unilateral adrenalectomy using standard stimulated cortisol cut-off values would wrongly label many patients adrenally insufficient and may lead to inappropriate prescriptions of steroids to patients who do not need them.
Anlotinib Combined With Chemotherapy for Recurrence of Pulmonary Sarcomatoid Cancer Previously Surgically Treated: A Case Report and Literature Review
Authors: Li Jing , Liang Hejun , He Jian , Sui Xin , Qin Yanru 
Published: May 2021

BackgroundPulmonary sarcomatoid cancer (PSC) is a very rare subtype of poorly differentiated non-small-lung-cancer (NSCLC) with very poor prognosis. To date, the optimal treatment for PSC has not been elucidated, and the efficacy of anlotinib in PSC has not been previously reported.Case PresentationA 77-year-old male patient was admitted with cough, expectoration, and blood-stained sputum for one month. CT showed a soft mass in the inferior lobe of the right lung, which was diagnosed as spindle cell carcinoma (PSC) by histopathology. A videothoracoscopic right lower lobectomy and mediastinal lymph node dissection procedure was performed on the patient, but the disease recurred one month after surgery. The patient was then given first-line chemotherapy with gemcitabine and albumin paclitaxel for one cycle, but the disease continued to progress. The patient then received anlotinib combined with second-line chemotherapy (dacarbazine and cis-platinum) for six cycles, and the response reached complete remission (CR). Then the patient was given maintenance therapy with anlotinib alone, and the disease was still stable at the most recent reexamination. Progression-free survival (PFS) has lasted for more than two years, without any intolerable toxicity.ConclusionThis postoperative recurrent PSC patient achieved significant clinical benefits with anlotinib treatment. Our findings provide direct evidence of the efficacy of anlotinib in PSC. More studies are needed to confirm our observation.
Three vs. Four Cycles of Neoadjuvant Chemotherapy for Localized Muscle Invasive Bladder Cancer Undergoing Radical Cystectomy: A Retrospective Multi-Institutional Analysis
Authors: Ferro Matteo , de Cobelli Ottavio , Musi Gennaro , Lucarelli Giuseppe , Terracciano Daniela , Pacella Daniela , Muto Tommaso , Porreca Angelo , Busetto Gian Maria , Del Giudice Francesco , Soria Francesco , Gontero Paolo , Cantiello Francesco , Damiano Rocco , Crocerossa Fabio , Farhan Abdal Rahman Abu , Autorino Riccardo , Vartolomei Mihai Dorin , Muto Matteo , Marchioni Michele , Mari Andrea , Scafuri Luca , Minervini Andrea , Longo Nicola , Chiancone Francesco , Perdona Sisto , De Placido Pietro , Verde Antonio , Catellani Michele , Luzzago Stefano , Mistretta Francesco Alessandro , Ditonno Pasquale , Caputo Vincenzo Francesco , Battaglia Michele , Zamboni Stefania , Antonelli Alessandro , Greco Francesco , Russo Giorgio Ivan , Hurle Rodolfo , Crisan Nicolae , Manfredi Matteo , Porpiglia Francesco , Di Lorenzo Giuseppe , Crocetto Felice , Buonerba Carlo 
Published: May 2021

BackgroundThree or four cycles of cisplatin-based chemotherapy is the standard neoadjuvant treatment prior to cystectomy in patients with muscle-invasive bladder cancer. Although NCCN guidelines recommend 4 cycles of cisplatin-gemcitabine, three cycles are also commonly administered in clinical practice. In this multicenter retrospective study, we assessed a large and homogenous cohort of patients with urothelial bladder cancer (UBC) treated with three or four cycles of neoadjuvant cisplatin-gemcitabine followed by radical cystectomy, in order to explore whether three vs. four cycles were associated with different outcomes.MethodsPatients with histologically confirmed muscle-invasive UBC included in this retrospective study had to be treated with either 3 (cohort A) or 4 (cohort B) cycles of cisplatin-gemcitabine as neoadjuvant therapy before undergoing radical cystectomy with lymphadenectomy. Outcomes including pathologic downstaging to non-muscle invasive disease, pathologic complete response (defined as absence of disease -ypT0), overall- and cancer-specific- survival as well as time to recurrence were compared between cohorts A vs. B.ResultsA total of 219 patients treated at 14 different high-volume Institutions were included in this retrospective study. Patients who received 3 (cohort A) vs. 4 (cohort B) cycles of neoadjuvant cisplatin-gemcitabine were 160 (73,1%) vs. 59 (26,9%).At univariate analysis, the number of neoadjuvant cycles was not associated with either pathologic complete response, pathologic downstaging, time to recurrence, cancer specific, and overall survival. Of note, patients in cohort B vs. A showed a worse non-cancer specific overall survival at univariate analysis (HR= 2.53; 95 CI= 1.05 - 6.10; p=0.046), although this finding was not confirmed at multivariate analysis.ConclusionsOur findings suggest that 3 cycles of cisplatin-gemcitabine may be equally effective, with less long-term toxicity, compared to 4 cycles in the neoadjuvant setting.
Antisense Tissue Factor Oligodeoxynucleotides Protected Diethyl Nitrosamine/Carbon Tetrachloride-Induced Liver Fibrosis Through Toll Like Receptor4-Tissue Factor-Protease Activated Receptor1 Pathway
Authors: Shouman Maha M. , Abdelsalam Rania M. , Tawfick Mahmoud M. , Kenawy Sanaa A. , El-Naa Mona M. 
Published: May 2021

Tissue factor (TF) is a blood coagulation factor that has several roles in many non-coagulant pathways involved in different pathological conditions such as angiogenesis, inflammation and fibrogenesis. Coagulation and inflammation are crosslinked with liver fibrosis where protease-activated receptor1 (PAR1) and toll-like receptor4 (TLR4) play a key role. Antisense oligodeoxynucleotides are strong modulators of gene expression. In the present study, antisense TF oligodeoxynucleotides (TFAS) was evaluated in treating liver fibrosis via suppression of TF gene expression. Liver fibrosis was induced in rats by a single administration of N-diethyl nitrosamine (DEN, 200 mg/kg; i. p.) followed by carbon tetrachloride (CCl4, 3 ml/kg; s. c.) once weekly for 6 weeks. Following fibrosis induction, liver TF expression was significantly upregulated along with liver enzymes activities and liver histopathological deterioration. Alpha smooth muscle actin (α-SMA) and transforming growth factor-1beta (TGF-1β) expression, tumor necrosis factor-alpha (TNF-α) and hydroxyproline content and collagen deposition were significantly elevated in the liver. Blocking of TF expression by TFAS injection (2.8 mg/kg; s. c.) once weekly for 6 weeks significantly restored liver enzymes activities and improved histopathological features along with decreasing the elevated α-SMA, TGF-1β, TNF-α, hydroxyproline and collagen. Moreover, TFAS decreased the expression of both PAR1 and TLR4 that were induced by liver fibrosis. In conclusion, we reported that blockage of TF expression by TFAS improved inflammatory and fibrotic changes associated with CCl4+DEN intoxication. In addition, we explored the potential crosslink between the TF, PAR1 and TLR4 in liver fibrogenesis. These findings offer a platform on which recovery from liver fibrosis could be mediated through targeting TF expression.