bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic pain severity, impact, and opioid use among patients with cancer: An analysis of biopsychosocial factors using the CHOIR learning health care system
Authors: Azizoddin Desiree R. , Schreiber Kristin , Beck Meghan R. , Enzinger Andrea C. , Hruschak Valerie , Darnall Beth D. , Edwards Robert R. , Allsop Matthew J. , Tulsky James A. , Boyer Edward , Mackey Sean 
Published: June 2021

BackgroundDespite the biopsychosocial underpinnings of chronic noncancer pain, relatively little is known about the contribution of psychosocial factors to chronic cancer pain. The authors aimed to characterize associations between biopsychosocial factors and pain and opioid use among individuals with chronic pain and cancer.MethodsThe authors conducted a retrospective, cross‐sectional study of 700 patients with chronic pain and cancer seeking treatment at an academic tertiary pain clinic. Patients completed demographic questionnaires and validated psychosocial and pain measures. Multivariable, hierarchical linear and logistic regressions assessed the relative contributions of biopsychosocial factors to the primary dependent variables of pain severity, pain interference, and opioid use.ResultsParticipants were 62% female and 66% White with a mean age of 59 ± 15 years, and 55% held a college degree or higher. Older age, African American or “other” race, sleep disturbance, and pain catastrophizing were significantly associated with higher pain severity (F(5,657) = 22.45; P ≤ .001; R2 = 0.22). Depression, sleep disturbance, pain catastrophizing, lower emotional support, and higher pain severity were significantly associated with pain interference (F(5,653) = 9.47; P ≤ .001; R2 = 0.44). Lastly, a poor cancer prognosis (Exp(B) = 1.62) and sleep disturbance (Exp(B) = 1.02) were associated with taking opioids, whereas identifying as Asian (Exp(B) = 0.48) or Hispanic (Exp(B) = 0.47) was associated with lower odds of using opioids.ConclusionsModifiable psychological factors—specifically sleep disturbance, depression, and pain catastrophizing—were uniquely associated with pain and opioid use in patients with chronic pain and diverse cancer diagnoses. Future behavioral pain interventions that concurrently target sleep may improve pain among patients with cancer.Lay Summary

Feeling depressed, worrying about pain, and bad sleep are related to higher pain symptoms in individuals with chronic pain and cancer.

Specifically, those who struggle to sleep have worse pain and use more opioids.

Also, individuals who have a bad prognosis for their cancer are more likely to be using opioid pain medications.

Although race and cancer are related to chronic pain in patients, psychological well‐being is also strongly related to this same pain.
How limited molecular testing can also offer diagnostic and prognostic evaluation of thyroid nodules processed with liquid‐based cytology: Role of TERT promoter and BRAF V600E mutation analysis
Authors: Dell’Aquila Marco , Fiorentino Vincenzo , Martini Maurizio , Capodimonti Sara , Cenci Tonia , Lombardi Celestino Pio , Raffaelli Marco , Pontecorvi Alfredo , Fadda Guido , Pantanowitz Liron , Larocca Luigi Maria , Rossi Esther Diana 
Published: June 2021

BackgroundMutational analysis contributes to the diagnosis and prognosis of thyroid nodules analyzed with fine‐needle aspiration cytology (FNAC). Although several advanced molecular tests based on multiple molecular markers are available for clinical use and have increased their impact on clinical management of patients, they are not widely available. Among them is BRAF V600E, one of the most studied mutations. Other genetic alterations, such as TERT promoter mutations, may coexist in thyroid carcinomas. Previous studies have demonstrated that this duet might be involved in the aggressiveness of thyroid cancer, although its prognostic value related to mortality remains undefined. The detection of such genetic alterations in thyroid liquid‐based cytology (LBC) thus may assist with patient management.MethodsFrom January 2013 to June 2014, 356 thyroid FNAC samples were processed by LBC, including 174 surgical follow‐up samples. BRAF V600E and TERT mutation analyses were performed on both LBC and histopathology.ResultsThe study included 119 samples categorized as atypia of undetermined significance, 42 categorized as follicular neoplasms, 61 categorized as suspicious for malignancy, and 34 categorized as positive for malignancy. BRAF V600E mutation was detected in 10.4% of all cases, whereas TERT promoter mutations were identified in 1.1%. TERT‐mutated cases belonged to the positive for malignancy category, with a histologic diagnosis of tall cell variant of papillary thyroid carcinoma. These genetic alterations correlated with lymph node metastases (P = .0349) and higher disease stage.ConclusionsBRAF V600E and TERT analysis can be performed on LBC. TERT mutations are rarely identified in well differentiated thyroid carcinoma but are associated with higher stage. Although a larger molecular panel may offer more information, analyzing these few point mutations is still likely to be useful for managing potentially more aggressive thyroid carcinomas.
Cytoarchitectural characteristics associated with cognitive flexibility in raccoons
Authors: Jacob Joanna , Kent Molly , Benson‐Amram Sarah , Herculano‐Houzel Suzana , Raghanti Mary Ann , Ploppert Emily , Drake Jack , Hindi Bilal , Natale Nick R. , Daniels Sarah , Fanelli Rachel , Miller Anderson , Landis Tim , Gilbert Amy , Johnson Shylo , Lai Annie , Hyer Molly , Rzucidlo Amanda , Anchor Chris , Gehrt Stan , Lambert Kelly 
Published: June 2021

AbstractWith rates of psychiatric illnesses such as depression continuing to rise, additional preclinical models are needed to facilitate translational neuroscience research. In the current study, the raccoon (Procyon lotor) was investigated due to its similarities with primate brains, including comparable proportional neuronal densities, cortical magnification of the forepaw area, and cortical gyrification. Specifically, we report on the cytoarchitectural characteristics of raccoons profiled as high, intermediate, or low solvers in a multiaccess problem‐solving task. Isotropic fractionation indicated that high‐solvers had significantly more cells in the hippocampus (HC) than the other solving groups; further, a nonsignificant trend suggested that this increase in cell profile density was due to increased nonneuronal (e.g., glial) cells. Group differences were not observed in the cellular density of the somatosensory cortex. Thionin‐based staining confirmed the presence of von Economo neurons (VENs) in the frontoinsular cortex, although no impact of solving ability on VEN cell profile density levels was observed. Elongated fusiform cells were quantified in the HC dentate gyrus where high‐solvers were observed to have higher levels of this cell type than the other solving groups. In sum, the current findings suggest that varying cytoarchitectural phenotypes contribute to cognitive flexibility. Additional research is necessary to determine the translational value of cytoarchitectural distribution patterns on adaptive behavioral outcomes associated with cognitive performance and mental health.
Not all applications have boring communication patterns: Profiling message matching with BMM
Authors: Groves Taylor , Ravichandrasekaran Naveen , Cook Brandon , Keen Noel , Trebotich David , Wright Nicholas J. , Alverson Bob , Roweth Duncan , Underwood Keith 
Published: June 2021

SummaryMessage matching within MPI is an important performance consideration for applications that utilize two‐sided semantics. In this work, we present an instrumentation of the CrayMPI library that allows the collection of detailed message‐matching statistics as well as an implementation of hashed matching in software. We use this functionality to profile key DOE applications with complex communication patterns to determine under what circumstances an application might benefit from hardware offload capabilities within the NIC to accelerate message matching. We find that there are several applications and libraries that exhibit sufficiently long match list lengths to motivate a Binned Message Matching approach.
Sharing non‐cache‐coherent memory with bounded incoherence
Authors: Ren Yuxin , Parmer Gabriel , Milojicic Dejan 
Published: June 2021

SummaryCache coherence in modern computer architectures enables easier programming by sharing data across multiple processors. Unfortunately, it can also limit scalability due to cache coherency traffic initiated by competing memory accesses. Rack‐scale systems introduce shared memory across a whole rack, but without inter‐node cache coherence. This poses memory management and concurrency control challenges for applications that must explicitly manage cache‐lines. To fully utilize rack‐scale systems for low‐latency and scalable computation, applications need to maintain cached memory accesses in spite of non‐coherency. This paper introduces Bounded Incoherence, a memory consistency model that enables cached access to shared data‐structures in non‐cache‐coherency memory. It ensures that updates to memory on one node are visible within at most a bounded amount of time on all other nodes. We evaluate this memory model on modified PowerGraph graph processing framework, and boost its performance by 30% with eight sockets by enabling cached‐access to data‐structures.
ZmMATE1 improves grain yield and yield stability in maize cultivated on acid soil
Authors: Vasconcellos Renato C. C. , Mendes Flávia F. , de Oliveira Antônio Carlos , Guimarães Lauro J. M. , Albuquerque Paulo E. P. , Pinto Marcos O. , Barros Beatriz A. , Pastina Maria Marta , Magalhaes Jurandir V. , Guimaraes Claudia T. 
Published: June 2021

AbstractThe development of aluminum (Al)‐tolerant cultivars is a complementary strategy to overcome the constraints caused by Al toxicity on acid soils and can contribute positively to the food supply for the growing global population. A major Al tolerance quantitative trait locus in maize is controlled by a citrate transporter encoded by ZmMATE1. Our goal was to evaluate the impact of the superior allele of ZmMATE1 on the yield performance of maize lines and hybrids cultivated on acid soils. Near‐isogenic lines carrying the superior allele of ZmMATE1, and the recurrent Al‐sensitive parent were crossed with elite lines, generating near‐isogenic hybrids contrasting for these alleles. All maize genotypes carrying this superior allele were more Al tolerant in nutrient solution than their isogenic counterparts having the ZmMATE1 allele derived from the Al‐sensitive parent. These genotypes were cultivated in control and Al stress soils for 2 yr. Aluminum toxicity caused a significant yield reduction of 18.7% for lines and 14.7% for hybrids over the 2 yr. The yield performance of maize genotypes declined in the second year compared with the first year, probably due to water deficiency after the grain‐filling stage. The superior allele of ZmMATE1 in maize hybrids conferred yield gains from 21 to 48% compared with the hybrids harboring the alternative allele in the Al stress soil in the first and second years, respectively. As this superior allele is rare in maize and is likely absent in several elite germplasms, molecular breeding based on ZmMATE1 can improve maize yield stability on acid soils.
Costly mating delays drive female ornamentation in a capital breeder
Authors: Hopkins Juhani , Lehtonen Topi K. , Baudry Gautier , Kaitala Arja 
Published: June 2021

Abstract

How fecundity might be traded off with mate attraction and other aspects of reproduction in females remains poorly understood.

We investigated these allocation trade‐offs using the common glowworm (Lampyris noctiluca), a lampyrid beetle, in which flightless, sedentary females only use resources gathered during the larval stage to attract flying males by glowing.

While sexual signaling was not found to have a significant fecundity cost, a delay in successfully attracting a mate greatly increased the risk of reproductive failure, with fecundity losses being more severe in small females.

These findings are among the first to show that failure to quickly attract a mate can decrease female fecundity. The results also show how the length of delay before mating can drive the evolution of female sexual ornamentation.
Fish community shifts along a strong fluvial environmental gradient revealed by eDNA metabarcoding
Authors: García‐Machado Erik , Laporte Martin , Normandeau Eric , Hernández Cecilia , Côté Guillaume , Paradis Yves , Mingelbier Marc , Bernatchez Louis 
Published: June 2021

AbstractLarge rivers and their estuaries are structurally complex and comprise a diversity of habitats supporting a rich biodiversity. As a result, identifying and monitoring fish communities using traditional methods in such systems may often be logistically challenging. Using the mitochondrial DNA 12S MiFish primers, we performed an eDNA metabarcoding analysis to assess the effect of spatial and environmental factors on the variation of the fish community structure along most of the St. Lawrence River/Estuary/Gulf (Québec Canada), a transect spanning 1300 km across a diversity of habitats from a fluviatile non‐tidal section to a marine environment. A total of 129 species were identified including freshwater and marine species. For the freshwater sectors, eDNA identified 80 species compared with the 85 species previously reported based on conventional sampling. eDNA also revealed similar species diversity and communities in the fluviatile section of the St. Lawrence River. Furthermore, our study improved current knowledge about the brackish and marine sections by describing community transition between freshwater and marine fish communities in association with a drastic shift in environmental conditions observed between the end of the fluvial estuary and the beginning of the middle (brackish) estuary. Altogether, this study exemplifies how eDNA metabarcoding is a powerful tool to document fish community shifts in large temperate lotic ecosystems.
Growth differentiation factor‐15, treatment with liraglutide, and clinical outcomes among patients with heart failure
Authors: Sharma Abhinav , Greene Stephen , Vaduganathan Muthiah , Fudim Marat , Ambrosy Andrew P. , Sun Jie‐Lena , McNulty Steven E. , Hernandez Adrian F. , Borlaug Barry A. , Velazquez Eric J. , Mentz Robert J. , DeVore Adam D. , Alhanti Brooke , Margulies Kenneth , Felker G. Michael 
Published: June 2021

AbstractAimsAssociations between growth differentiation factor‐15 (GDF‐15), cardiovascular outcomes, and exercise capacity among patients with a recent hospitalization for heart failure (HHF) and heart failure with reduced ejection fraction (HFrEF) are unknown. We utilized data from the ‘Functional Impact of GLP‐1 for Heart Failure Treatment’ (FIGHT) study to address these knowledge gaps.Methods and resultsFIGHT was a randomized clinical trial testing the effect of liraglutide (vs. placebo) among 300 participants with HFrEF and a recent HHF. Multivariable regression models evaluated associations between baseline GDF‐15 and change in GDF‐15 (per 1000 pg/mL increase from baseline to 30 days) with clinical outcomes (at 180 days) and declines in exercise capacity (6 min walk distance ≥ 45 m). At baseline (n = 249), median GDF‐15 value was 3221 pg/mL (interquartile range 1938–5511 pg/mL). Participants in the highest tertile of baseline GDF‐15 were more likely to be male and have more co‐morbidities. After adjustment, an increase in GDF‐15 over 30 days was associated with higher risk of death or HHF [hazard ratio 1.35, 95% confidence interval (CI) 1.11–1.64]. In addition, higher baseline GDF‐15 (per 1000 pg/mL until 6000 pg/mL) and an increase in GDF‐15 over 30 days were associated with declining 6 min walk distance (odds ratio 1.26, 95% CI 1.02–1.55 and odds ratio 1.37, 95% CI 1.12–1.69, respectively). GDF‐15 levels remained stable among participants randomized to liraglutide.ConclusionsAn increase in GDF‐15 over 30 days among patients in HFrEF was independently associated with an increased risk of cardiovascular events and declining exercise capacity. These results support the value of longitudinal GDF‐15 trajectory in informing risk of heart failure disease progression.
Leaching of Metals from Steel Slag and Their Ecological Effects on a Marine Ecosystem: Validating Field Data with Mesocosm Observations
Authors: Foekema Edwin M. , Tamis Jacqueline E. , Blanco Ainhoa , van der Weide Babeth , Sonneveld Cor , Kleissen Frank , van den Heuvel-Greve Martine J. 
Published: June 2021

Abstract
Steel slag is being used worldwide for a variety of applications, among which is underwater dyke reinforcement. In the present study the leaching and bioaccumulation of 18 inorganic compounds from basic oxygen furnace (BOF) steel slag were monitored in marine experimental ecosystems (mesocosms) for 12 wk. Triplicate mesocosms were installed at 2 refreshment rates, one reflecting the situation in the Oosterschelde estuary where BOF steel slag was applied and the other at a 35 times lower rate. Vanadium in both water and biota turned out to be the best tracer for the presence of BOF steel slag in the mesocosms. The mesocosm data helped to interpret the results of a 4-yr field sampling program in the Oosterschelde estuary where no elevated levels of vanadium in water or biota were found near locations where steel slag was applied. Also, no ecological impact could be established in the field, which was in line with the observations in the mesocosms. The present study shows the added value of a tailor-made mesocosm study for realistic risk assessment and provides support for applying this tool as a basis for designing efficient field monitoring programs. Environ Toxicol Chem 2021;40:2499–2509. © 2021 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
The synergistic effects of zinc oxide nanoparticles and fennel essential oil on physicochemical, mechanical, and antibacterial properties of potato starch films
Authors: Babapour Hamid , Jalali Hossein , Mohammadi Nafchi Abdorreza 
Published: June 2021

AbstractThe purpose of this study was to evaluate the effects of a combination of zinc oxide (ZnO‐N) nanoparticles and fennel essential oil (FEO) on the functional and antimicrobial properties of potato starch films. Films based on potato starch containing a combination of ZnO‐N (1, 3, and 5%(w/w)) and FEO (1, 2, and 3% (w/w)) produced by casting method and water solubility, water absorption capacity (WAC), barrier properties, mechanical properties, color indexes, and antimicrobial activity of the films against Staphylococcus aureus, Escherichia coli, and Aspergillus flavus were studied. The combination of ZnO‐N and FEO had a significant decreasing effect on solubility, WAC, water vapor and oxygen permeability, elongation, and L* index. These additives had an increasing impact on tensile strength, Yang's modulus, and a* and b* indexes (p < .05). By increasing the concentration of ZnO‐N and FEO, the antimicrobial activities of bionanocomposite films significantly increased (p < .05). Both ZnO‐N and FEO had a significant effect in this respect, although the effects of ZnO‐N were more significant. In conclusion, an excellent synergistic effect of ZnO‐N and FEO was observed in potato starch films.
Who leads in intraday gold price discovery and volatility connectedness: Spot, futures, or exchange‐traded fund?
Authors: Sehgal Sanjay , Sobti Neharika , Diesting Florent 
Published: June 2021

AbstractGold exchange‐traded funds (ETFs) have amassed massive inflows from institutional investors globally. We examine intraday price discovery and volatility connectedness among three gold instruments—spot, futures, and ETF—across mature and emerging gold markets in domestic and international settings from 2010 to 2018. Using the network approach, we find that gold futures are a global leader in price discovery and volatility spillover. However, during 2016–2018, physical‐gold‐backed ETF and spot challenge the futures' leadership in New York and Shanghai. Intraday variation in price discovery leadership is due to liquidity, hedging effectiveness, price jumps, investor attention, and macroeconomic states.
Mechanisms underlying sensitization of P2X7 receptors in astrocytes for induction of ischemic tolerance
Authors: Hirayama Yuri , Anzai Naohiko , Koizumi Schuichi 
Published: June 2021

AbstractWe previously showed that noninvasive mild ischemia (preconditioning; PC) induced ischemic tolerance by upregulation of P2X7 receptors in astrocytes via a hypoxia inducible factor‐1α (HIF‐1α)‐dependent mechanism. The P2X7 receptor is known as a low‐sensitivity P2 receptor that requires a high extracellular ATP (eATP) concentration for activation. PC increased the eATP level but was not sufficient to activate P2X7 receptors. Here, we show that astrocytes possess an elaborate mechanism for activation of P2X7 receptors, thus contributing to ischemic tolerance. Nicotinamide adenine dinucleotide (NAD+) was shown to increase the sensitivity of P2X7 receptors to eATP via ecto‐ADP‐ribosyltransferase 2 (ARTC2)‐catalyzed ADP‐ribosylation in peripheral immune cells. Although ARTC2‐positive signals were mostly absent in the naïve brain, they were selectively increased in astrocytes by PC. The spatiotemporal pattern of PC‐evoked ARTC2 was well associated with that of P2X7 receptors. In the in vitro experiments, NAD+ increased the sensitivity of P2X7 receptors to ATP, and at higher concentrations, NAD+ itself activated P2X7 receptors without eATP in cultured astrocytes. In the in vivo experiments using middle cerebral artery occlusion model mice, the PC‐evoked increase in HIF‐1α in astrocytes was abolished by the ARTC2 inhibitor S + 16a. S + 16a also abolished PC‐evoked ischemic tolerance. Taken together, the results suggested that P2X7 receptors can be sensitized to ATP by NAD+/ARTC2‐catalyzed ADP‐ribosylation, which allows astrocytes to drive P2X7 receptor‐mediated ischemic tolerance even though PC only slightly increases the amount of eATP.
Altered resting‐state functional network connectivity in profound sensorineural hearing loss infants within an early sensitive period: A group ICA study
Authors: Wang Shanshan , Chen Boyu , Yu Yalian , Yang Huaguang , Cui Wenzhuo , Fan Guoguang , Li Jian 
Published: June 2021

AbstractData from both animal models and deaf children provide evidence for that the maturation of auditory cortex has a sensitive period during the first 2–4 years of life. During this period, the auditory stimulation can affect the development of cortical function to the greatest extent. Thus far, little is known about the brain development trajectory after early auditory deprivation within this period. In this study, independent component analysis (ICA) technique was used to detect the characteristics of brain network development in children with bilateral profound sensorineural hearing loss (SNHL) before 3 years old. Seven resting‐state networks (RSN) were identified in 50 SNHL and 36 healthy controls using ICA method, and further their intra‐and inter‐network functional connectivity (FC) were compared between two groups. Compared with the control group, SNHL group showed decreased FC within default mode network, while enhanced FC within auditory network (AUN) and salience network. No significant changes in FC were found in the visual network (VN) and sensorimotor network (SMN). Furthermore, the inter‐network FC between SMN and AUN, frontal network and AUN, SMN and VN, frontal network and VN were significantly increased in SNHL group. The results implicate that the loss and the compensatory reorganization of brain network FC coexist in SNHL infants. It provides a network basis for understanding the brain development trajectory after hearing loss within early sensitive period.