bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shrinking the Upper Confidence Bound: A Dynamic Product Selection Problem for Urban Warehouses
Authors: Jin Rong , Simchi-Levi David , Wang Li , Wang Xinshang , Yang Sen 
Published: January 2021

The recent rising popularity of ultrafast delivery services on retail platforms fuels the increasing use of urban warehouses, whose proximity to customers makes fast deliveries viable. The space limit in urban warehouses poses a problem for such online retailers: the number of stock keeping units (SKUs) they carry is no longer “the more, the better,” yet it can still be significantly large, reaching hundreds or thousands in a product category. In this paper, we study algorithms for dynamically selecting a large number of products (i.e., SKUs) with top customer purchase probabilities on the fly, from an ocean of potential products to offer on retailers’ ultrafast delivery platforms. We distill the product selection problem into a semibandit model with linear generalization. There are in total N arms corresponding to N products, each with a feature vector of dimension d. The player pulls K arms in each period and observes the bandit feedback from each of the pulled arms. We focus on the setting where K is much greater than the number of total time periods T or the dimension of product features d. We first analyze a standard Upper Confidence Bound (UCB) algorithm and show its regret bound can be expressed as the sum of a T-independent part and a T-dependent part, which we refer to as “fixed cost” and “variable cost,” respectively. To reduce the fixed cost for large K values, we propose a novel online learning algorithm, which iteratively shrinks the upper confidence bounds within each period, and show its fixed cost is reduced by a factor of d. Moreover, we test the algorithms on an industrial data set from Alibaba Group. Experimental results show that our new algorithm reduces the total regret of the standard UCB algorithm by at least 10%. This paper was accepted by J. George Shanthikumar, big data analytics.
Ordenar la casa. Securitización, jerarquización y regulación del espacio urbano en la política de Cambiemos en La Plata (2015-2019)
Authors: Segura Ramiro , Vélez Joaquín 
Published: January 2021

O artigo discute a política urbana de Cambiemos na cidade de La Plata, capital da província de Buenos Aires, durante o período 2015-2019. La Plata. Você está em casa foi o slogan de governança desta coalizão política de direita que implementou um conjunto de políticas urbanas destinadas a “ordenar a (cidade como) casa”. A partir de um diagnóstico decadente do estado da cidade difundido entre as classes média e alta, bem como um imaginário urbano em relação à deve ser a cidade, a política de securitização de Cambiemos operava como um poderoso dispositivo de hierarquia e regulação do espaço urbano. Combinando repressão, policiamento e prevenção, essas políticas buscavam regular quem pode fazer o que, onde e quando, e envolveu o deslocamento, marginalização e/ou expulsão de práticas e pessoas informais (feirantes, vendedores nas ruas, prostituição, centros culturais, entre outros) para gerar condições de investimento urbano. Em suma, foi a implantação do urbanismo “revanchista” e “autoritário” que, em nome da segurança e prevenção, implementou o modelo de “a cidade como casa”, regulando, deslocando e até expulsando o que é considerado “fora do lugar”. Quem (não) entra em casa? A imagem da cidade como casa tem afiliações políticas conservadoras e abre questões fundamentais sobre à vida urbana democrática, como liberdade de acesso, condições iguais, direito a (in)diferença, e possibilidades de diálogo e dissidência em espaços que, por definição, constituem áreas de encontro entre diferentes e desiguais.
Evento de movimento transitivo: uso e cognição
Authors: Cunha Maria Angélica Furtado da , César Alan Marinho 
Published: January 2021

Este artigo focaliza a codificação semântico-sintática da construção de movimento transitivo, com o objetivo de tratar da relação entre o tipo de evento expresso pela construção e os esquemas cognitivos por ela acionados. A base teórica que fundamenta este trabalho conjuga a Linguística Funcional Centrada no Uso, a Linguística Cognitiva e a Gramática de Construções, investigando aspectos estruturais, semânticos, funcionais e cognitivos presentes nas instanciações dessa construção. Os dados empíricos foram coletados de fontes diversas: o Corpus Discurso & Gramática, o Banco de Sentenças da Justiça Federal do Rio Grande do Norte, o Banco de Dados do Programa de Estudos Sobre o Uso da Língua da UFRJ e textos disponíveis online em sites de revistas de ampla circulação. Os resultados da pesquisa revelam a existência de um esquema construcional que sanciona três subesquemas e sete microconstruções que, por sua vez, revelam noções de movimento causado, movimento percorrido e movimento associado. Da perspectiva sintático-semântica, a codificação linguística do evento de movimento transitivo projeta frames que manifestam diferentes tipos de movimento, como manipulação, transporte e deslocamento; em termos de estrutura cognitiva, os esquemas imagéticos apontam o traço focalizado do trajeto.
Real Estate trifft auf Blockchain: Chancen und Herausforderungen der Tokenisierung von illiquiden Vermögenswerten
Authors: Markheim Marina , Berentsen Aleksander 
Published: January 2021

ZusammenfassungDer vorliegende Artikel analysiert die Chancen und Herausforderungen der Tokenisierung von Immobilien. Zunächst werden die theoretischen Grundlagen (Blockchain und Smart Contracts) sowie die Vor- und Nachteile der Tokenisierung diskutiert. Die Umsetzung der Tokenisierung einer Immobilie wird anschließend anhand eines Praxisbeispiels veranschaulicht. Die Vorteile einer Tokenisierung liegen in dem sofortigen weltweiten Handel der Token rund um die Uhr, dem Eigentumsübertrag der Token in „real time“, der Standardisierung bei gleichzeitiger Flexibilität, der Transparenz und Sicherheit im Handel der Token. Zudem ist die technische Umsetzung der Tokenisierung einer Immobilie sehr einfach. Regulatorische Unsicherheiten beschränken jedoch zurzeit noch eine breite Anwendung der Technologie.
How do city-specific factors affect migrant integration in China? A study based on a hierarchical linear model of migrants and cities
Authors: Zheng Rumin , Mei Lin , Guo Yanhua , Zhen Shuo , Fu Zhanhui 
Published: January 2021

Background
Previous studies indicate that migrant integration is associated with migrants’ characteristics as well as restrictions and opportunities in receiving cities. However, the effect of receiving cities and the relationship between migrants and receiving cities have not been fully explored due to the lack of large samples from cities. The objective of this study is to examine the effects of receiving cities alone and their regulating role in the interaction with individual characteristics.

Methods
Cross-city data on 154,044 Chinese domestic migrants above 15 years old in 289 cities from the 2017 China Migrants Dynamic Survey are used. Migrant integration is assessed by a four-dimensional model proposed by Esser, which is slightly adjusted according to the characteristics of Chinese migrants. A hierarchical linear model is used to measure the proportion of effects of city factors in migrant integration as well as the effects when city factors are considered alone and in interaction with individual factors.

Results
The individual-level and city-level factors are responsible for 69.81% and 30.19% of the effect on migrant integration, respectively. City political factors do not affect migrant integration directly, and cities with larger sizes and higher wages can directly and significantly improve integration, while higher housing prices will directly inhibit integration. From the cross-level interaction of city and individual, different social, economic and political factors at the city level have an indirect impact on migrant integration by inhibiting or strengthening the effect of individual-level factors on migrant integration.

Conclusion
This study is one of the first to show the effect of cities and the relationship between receiving cities and migrants on migrant integration by keeping the national context constant. It is necessary to weaken the social and economic privileges associated with a city’s administrative level and reduce the negative impact of cities’ social and economic conditions by implementing city agglomeration, developing advantageous industries and optimizing the industrial structure. It is also essential to improve migrants’ socioeconomic capital through social support, occupation training and contiguous education.
The contributions of focused attention and open monitoring in mindfulness-based cognitive therapy for affective disturbances: A 3-armed randomized dismantling trial
Authors: Cullen Brendan , Eichel Kristina , Lindahl Jared R. , Rahrig Hadley , Kini Nisha , Flahive Julie , Britton Willoughby B. 
Published: January 2021

ObjectiveMindfulness-based cognitive therapy (MBCT) includes a combination of focused attention (FA) and open monitoring (OM) meditation practices. The aim of this study was to assess both short- and long-term between- and within-group differences in affective disturbance among FA, OM and their combination (MBCT) in the context of a randomized controlled trial.MethodOne hundred and four participants with mild to severe depression and anxiety were randomized into one of three 8-week interventions: MBCT (n = 32), FA (n = 36) and OM (n = 36). Outcome measures included the Inventory of Depressive Symptomatology (IDS), and the Depression Anxiety Stress Scales (DASS). Mixed effects regression models were used to assess differential treatment effects during treatment, post-treatment (8 weeks) and long-term (20 weeks). The Reliable Change Index (RCI) was used to translate statistical findings into clinically meaningful improvements or deteriorations.ResultsAll treatments demonstrated medium to large improvements (ds= 0.42–1.65) for almost all outcomes. While all treatments were largely comparable in their effects at post-treatment (week 8), the treatments showed meaningful differences in rapidity of response and pattern of deteriorations. FA showed the fastest rate of improvement and the fewest deteriorations on stress, anxiety and depression during treatment, but a loss of treatment-related gains and lasting deteriorations in depression at week 20. OM showed the slowest rate of improvement and lost treatment-related gains for anxiety, resulting in higher anxiety in OM at week 20 than MBCT (d= 0.40) and FA (d= 0.36), though these differences did not reach statistical significance after correcting for multiple comparisons (p’s= .06). MBCT and OM showed deteriorations in stress, anxiety and depression at multiple timepoints during treatment, with lasting deteriorations in stress and depression. MBCT showed the most favorable pattern for long-term treatment of depression.ConclusionsFA, OM and MBCT show different patterns of response for different dimensions of affective disturbance.Trial registrationThis trial is registered at (vNCT01831362);www.clinicaltrials.gov.
Platelets express adaptor proteins of the extrinsic apoptosis pathway and can activate caspase-8
Authors: Goelz Nadine , Eekels Julia J. M. , Pantic Milica , Kamber Christoph T. , Speer Oliver , Franzoso Francesca D. , Schmugge Markus 
Published: January 2021

BackgroundApoptotic pathways in platelets are important for their survival and function. Platelet apoptosis may be involved in the pathogenesis of immune thrombocytopenia (ITP), an autoimmune-mediated disease. In contrast to the intrinsic apoptosis pathway, not much is known about the extrinsic pathway mechanisms in platelets.ObjectivesTo investigate the expression of proteins involved in the extrinsic apoptosis pathway, including the death receptors, adaptor and regulator proteins in human platelets. To determine a possible trigger of the extrinsic apoptosis pathway in platelets.MethodsTo investigate the expression of key markers of the extrinsic pathway we used targeted immunofluorescence and flow cytometry assays. To study their expression and interaction we performed Western blotting and co-immunoprecipitation. Treated platelets with different apoptosis triggers were subjected to flow cytometry.ResultsWe could identify the protein expression of the pro-apoptotic proteins TRADD (Tumor Necrosis Factor Receptor type 1- Associated DEATH Domain protein), TRAF2/5, (TNF Associated Factor) and DEDAF (Death Effector Domain- Associated Factor), FADD (Fas-Associated protein with death domain) as well as the anti-apoptotic proteins DJ-1 (Deglycase 1) and c-FLIP in human platelets. ABT-737 treatment induced a disruption in the co-localization of DJ-1 with FADD. Platelets treated with ABT-737 showed an activation in caspase-3 and -8. The exposure to TNF (Tumor Necrosis Factor), FasL (Fas ligand), and TWEAK or to plasma derived from ITP patients, did not lead to changes in caspase-3 and -8 activation in platelets.ConclusionsHuman platelets express some proteins of the extrinsic apoptosis pathway which can be modulated only by ABT-737 treatment. However so far, no other apoptosis trigger or interaction with an external receptor have been yet identified.
Profile of risk factors for Non-Communicable Diseases (NCDs) in a highly urbanized district of India: Findings from Puducherry district-wide STEPS Survey, 2019–20
Authors: Sivanantham Parthibane , Sahoo Jayaprakash , Lakshminarayanan Subitha , Bobby Zachariah , Kar Sitanshu Sekhar 
Published: January 2021

Introduction
Rapid urbanization and industrialization drives the rising burden of Non-Communicable Diseases (NCDs) worldwide that are characterized by uptake of unhealthy lifestyle such as tobacco and alcohol use, physical inactivity and unhealthy diet. In India, the prevalence of various NCDs and its risk factors shows wide variations across geographic regions necessitating region-specific evidence for population-based prevention and control of NCDs.

Objective
To estimate the prevalence of behavioral and biological risk factors of NCDs among adult population (18–69 years) in the Puducherry district located in Southern part of India.

Methodology
We surveyed adults using the World Health Organization (WHO) prescribed STEPwise approach to NCD surveillance (STEPS) during February 2019 to February 2020. A total of 2560 individuals were selected from urban and rural areas (50 clusters in each) through multi-stage cluster random sampling method. STEPS instrument was used to assess behavioral and physical measurements. Fasting blood sample was collected to estimate biochemical risk factors (Diabetes, Hypercholesterolemia) of NCDs.

Results
Among men, alcohol use 40.4% (95% CI: 37.4–43.4) was almost twice higher compared to tobacco use 24.4% (95% CI: 21.7–26.9). Nearly half of the population was physically inactive 45.8% (95% CI: 43.8–47.8) and obese 46.1% (95% CI: 44–48.1). Hypertension and diabetes mellitus were present among one-third 33.6% (95% CI: 31.6–35.5) and one-fourth 26.7% (95% CI: 24.1–29.1) of the population which were significantly higher among men (37.1% vs 30.8% and 31.6% vs 23.2% respectively). Physical inactivity and overweight/obesity increased with increasing education levels. Tobacco and alcohol use was more common among men, whereas physical inactivity with obesity and hypercholesterolemia was higher among women.

Conclusion
We found high prevalence of various NCDs and its risk factors among the adult population of Puducherry district.
Efficacy of 0.05% cyclosporine A on the lipid layer and meibomian glands after cataract surgery: A randomized, double-masked study
Authors: Kang Min Seung , Shin Jonghoon , Kwon Jeong Min , Huh Jin , Lee Ji Eun 
Published: January 2021

Purpose
To quantitatively evaluate the effects of 0.05% cyclosporine A (CsA) on lipid layer thickness (LLT) and meibomian glands after cataract surgery using the LipiView® ocular surface interferometer.

Methods
This study was a prospective randomized double-masked clinical trial conducted by Pusan National University Yangsan Hospital between April 04, 2019, and November 31, 2019. Sixty-two participants were recruited, and 12 of them were not enrolled because they had undergone previous treatments for ocular surface diseases. The participants were adult patients with cataract, exhibiting normal lid position; they did not present any other ocular disease and did not meet the exclusion criteria of the clinical trial. Fifty subjects were enrolled in the study. The randomized subjects received treatment with 0.05% CsA (group A) or 0.5% carboxymethyl cellulose (CMC) (group B) over the 3 months following the cataract surgery. Subjective and objective assessments were performed at preoperative and postoperative visits. Ocular Surface Disease Index (OSDI), tear breakup time (TBUT), and Schirmer’s I test were performed by the same surgeon, and LLT and meiboscore were determined using the LipiView® interferometer.

Results
Fifty subjects subjects enrolled consisted of men (50%) and women (50%), with a mean (SD) age of 65.94 (10.35) years. Four subjects in group A and five in group B were excluded from the analysis as they were lost to follow-up within 1 month after cataract surgery. Thus, the study comprised 41 eyes of 41 subjects; 21 subjects were treated with CsA and 20 subjects with CMC. Comparing the clinical measurements between groups A and B taken at the last visit, while controlling the effects of the preoperative values, TBUT and LLT showed significant differences (p = 0.035 and p = 0.047, respectively, by ANCOVA). The TBUT between the subjects using CsA and those using CMC after cataract surgery showed a significant difference during follow up (p = 0.003 by repeated measures ANOVA). In the multivariate analysis, preoperative LLT and the use of CsA were found to be independent parameters for postoperative LLT (R2 = 0.303; p = 0.008 and p = 0.045, respectively), whereas the follow-up duration exhibited a positive correlation with the difference between the preoperative and postoperative values of LLT in the group treated with CsA (R2 = 0.738 and p < 0.001).

Conclusion
Treatment with 0.05% CsA following cataract surgery is effective in improving TBUT and LLT in comparison with 0.5% CMC. A higher preoperative value of LLT and the postoperative use of CsA could be significant determinants of a higher postoperative LLT value.

Trial registration
ISRCTN registry with ISRCTN 10173448.
The geographical maldistribution of obstetricians and gynecologists in Japan
Authors: Matsumoto Kunichika , Seto Kanako , Hayata Eijiro , Fujita Shigeru , Hatakeyama Yosuke , Onishi Ryo , Hasegawa Tomonori 
Published: January 2021

Background
In Japan, there is a large geographical maldistribution of obstetricians/gynecologists, with a high proportion of females. This study seeks to clarify how the increase in the proportion of female physicians affects the geographical maldistribution of obstetrics/gynecologists.

Methods
Governmental data of the Survey of Physicians, Dentists and Pharmacists between 1996 and 2016 were used. The Gini coefficient was used to measure the geographical maldistribution. We divided obstetricians/gynecologists into four groups based on age and gender: males under 40 years, females under 40 years, males aged 40 years and above, and females aged 40 years and above, and the time trend of the maldistribution and contribution of each group was evaluated.

Results
The maldistribution of obstetricians/gynecologists was found to be worse during the study period, with the Gini coefficient exceeding 0.400 in 2016. The contribution ratios of female physicians to the deterioration of geographical maldistribution have been increasing for those under 40 years and those aged 40 years and above. However, there was a continuous decrease in the Gini coefficient of the two groups.

Conclusions
The increase in the contribution ratio of the female physician groups to the Gini coefficient in obstetrics/gynecology may be due to the increased weight of these groups. The Gini coefficients of the female groups were also found to be on a decline. Although this may be because the working environment for female physicians improved or more female physicians established their practice in previously underserved areas, such a notion needs to be investigated in a follow-up study.
Gynecological malignancy mimicking a thyroid lymph node metastasis
Authors: Pederzoli Simone , Spaggiari Giorgia , Bernardelli Giuditta , Mattioli Francesco , Baldessari Cinzia , Maiorana Antonino , Rochira Vincenzo , Santi Daniele 
Published: January 2021

Summary
We present the case of a 69-year-old woman who attended the Endocrinology Unit of Modena for a suspicious lymph node in the left cervical compartment discovered during the follow-up of a recurrent gynecological malignancy. At neck ultrasonography, a thyroid goiter was detected, and the further cytological examination was inconclusive for thyroid nodule and compatible with a localization of an adenocarcinoma with papillary architecture for the lymph node. The histological examination after a left neck dissection confirmed the presence of an intracapsular metastasis of a papillary carcinoma immunohistochemically focally positive for thyroid transcription factor 1 and paired box 8 and negative for thyroglobulin. Subsequently, in the suspicion of a thyroid primitiveness, a total thyroidectomy was performed, revealing an intraparenchymal follicular variant of papillary thyroid carcinoma of 2 mm in the right lobe. During the follow-up, the appearance of a suspected cervical metastatic lesion led to another neck dissection, histologically compatible with a papillary carcinoma localization, immunohistochemically focally positive for thyroid transcription factor 1 and paired box 8, and negative for thyroglobulin. The histological revision of surgical specimens suggests the cervical recurrence of the prior gynecological cancer, rather than a thyroid carcinoma metastasis. The case described shows how carefully the cytological, histological and immunoistochemical results must be evaluated in oncological management, considering the whole patient’s history.

Learning points:

Neck lymph node metastases occasionally originate from anatomically distant primary sites, such as breast, lung, gastro-intestinal tract, genito-urinary tract and CNS.

Histological and immunohistochemical evaluations play an important role to identify the primary malignant site, although in some cases they could mislead the clinicians.

A multidisciplinary approach and the evaluation of the whole medical history of the patient are mandatory to guide the diagnostic-therapeutic path and to avoid unnecessary treatments.
Hypopituitarism in Wilson’s disease resolved after copper-chelating therapy
Authors: Dauth Nina , Mücke Victoria T , Mücke Marcus M , Lange Christian M , Welker Martin , Zeuzem Stefan , Badenhoop Klaus 
Published: January 2021

Summary
Wilson’s disease (WD) is a rare disorder of copper metabolism usually presenting with variable liver damage and neuropsychiatric symptoms. Here we report a 39-year-old Taiwanese female with late manifestation of WD presenting with gonadotroph, thyreotroph and corticotroph hypopituitarism. Molecular genetic testing revealed compound heterozygosity for two mutations in exons 12 and 14 (c.2828G>A and c.3140A>T). Copper-chelating therapy with D-penicillamine and zinc was initiated along with supplementation of hydrocortisone and L-thyroxine. Hypopituitarism resolved when urinary copper excretion returned to normal levels under copper chelation. This case should raise awareness of pituitary function in WD patients.

Learning points

Hypopituitarism can complicate Wilson’s disease (WD) and endocrinologists should be aware of it when caring for hypopituitary patients.

Hepatologists should consider endocrinologic testing for hypopituitarism when WD patients present with symptoms of adrenal insufficiency, thyroid or gonadal dysfunction.

Copper-chelating treatment is mandatory and may lead to the recovery of pituitary function in such patients.