bluuebunny/crossref_metadata_2025_split huggingface dataset:
Homocysteine as a prognostic indicator for women with pregnancy-induced hypertension-a proportional study of homocysteine levels in normal versus pre-eclamptic women.
Authors: Zia Mudasir , Mahmood Maira , Namoos Kiran , Fayyaz Irum , Ashraf Huma , Javed Arham 
Published: September 2021

Objective: To find the probable role of Homocysteine as a prognostic indicator for women with Pregnancy-Induced Hypertension and comparison of Homocysteine Levels in Normal Versus pre-eclamptic women. Study Design: Cross Sectional Comparative study. Setting: Gynecology Unit of Lahore General Hospital, Lahore. Period: May 2017 to Oct 2017. Material & Methods: Thirty four consented pre-eclamptic pregnant women with age range 29 to 35 years were included in the study. 20 age matched pregnant women with no history of any clinical problem were taken as controls. A questionnaire based on age, obstetric details including detail of gravida, family history etc was filled by both subjects and controls. Anthropometric parameters were noted based on height and weight. Blood sample of both patients and controls was drawn for estimation of blood urea, serum creatinine, and homocysteine. Results: Mean age of women was 31 year with BMI 27.0 Kg/m2. Levels of serum homocysteine were significantly more women with pre-eclampsia in comparison with cases of controls. However the values of blood urea and serum creatinine were insignificantly high in pre-eclamptic women in comparison with their controls. Conclusion: Serum homocysteine as a biomarker may help to find out its additive importance in the prediction of pre-eclampsia and the severity of its related complications.
Tricupsid valve involvement in chronic rheumatic mitral stenosis: An observational study.
Authors: Baqai Lubna , - Shazia , Nasim Naveen , Baloch Erum , Gurmani Sumyia , Khaliq Kubra 
Published: September 2021

Objective: The aim of this study was to assess the incidence of tricuspid valve involvement in rheumatic mitral stenosis among Pakistani patients that helps in the medical decisions and special consideration for the management of disease. Study Design: Prospective Study. Setting: National Institute of Cardiovascular Disease (NICVD), Karachi. Period: February 2018 to November 2019. Material & Methods: As per the study inclusion criteria, Three fifty eight (358) Pakistani patients' diagnosed with Rheumatic Mitral stenosis. The study was compiled as per international standards (ICH-GCP-E6), prior to initiation, the ethics review committee approved the study and informed consent was taken from all recruited subjects. Results: The study prospectively assessed the echocardiographic profile of rheumatic heart disease patients and recruited 358 patients with chronic Rheumatic Mitral Stenosis. Out of these patients, 93.9% (336) had tricuspid regurgitation and 7% (25) had triscuspid stenosis. Their ages ranged from 14 to 85 years (mean 40.3 years). Of these, 73.6% (263) were females and 26.5% (95) were males. On the basis of severity, in case of tricuspid stenosis, 3.9% (14) were mild, 1.1% (4) were moderate and 2% (7) were progress from mild to moderate. In case of Tricuspid regurgitation, 39.9% (143) were mild, 29% (105) moderate and 88% (24.6) were severe. Conclusion: The study concluded that in the local population, the patients with chronic Rheumatic Mitral Stenosis had common involvement of Triscuspid valvular disease, more come in female and affected all age groups. Hence, before management of Rheumatic Mitral Stenosis with other lesions, especially the Triscuspid valve involvement, detailed assessment is required in order to achieve the best outcome in patients with the Mitral valve disease.
Comparison of gray scale versus Doppler ultrasound to detect deep venous thrombosis in lower extremities.
Authors: Tauqir Javed , Tazeen Anjum , Khadija Syeda , Fatima Mehreen , Zakir Muhammad , Gilani Syed Yousaf 
Published: September 2021

Objectives: The objective was to determine the accuracy of Gray Scale versus Doppler Ultrasound to Detect Deep Venous Thrombosis in Lower Extremities. Study Design: Cross Sectional Analytical study. Setting: The University of Lahore and Shalimar Hospital Lahore. Period: May to October 2020. Material & Methods: After a permission from the ethical committee and a written consent of the patients, on the basis of the clinical suspicions of deep vein thrombosis, A total of 140 patients of both the genders, aging from 20 to 90 years, were referred for Gray Scale & Doppler ultrasound examination. The convenient sampling technique and Statistical software for social sciences (SPSS version 22.0) were used for the analysis of data. Results: In 140 patients’ present study on Gray Scale ultrasound, 120 (85%) cases were observed with significantly increased blood vessel size, intraluminal echogenicity and a loss of compressibility However, on Doppler ultrasound, 130 (92%) cases were detected possessing significantly increased blood vessel size, intraluminal echogenicity, absence of blood flow and negative augmentation effect. Conclusions: From the result of present study, it is concluded that Doppler may be used as gold standard to diagnose the DVT in the lower extremities. This study concludes also that DVT detection accuracy difference between Doppler and Gray Scale ultrasound is minor i.e. 1:1.08. This minor difference encourages the radiology practitioners of periphery to screen DVT in lower extremities through Gray Scale ultrasound, if Doppler ultrasound is unavailable there.
Hubungan Shift Kerja dengan Kualitas Tidur pada Pekerja Perusahaan Fast Moving Consumer Goods (FMCG) Tahun 2020
Authors: Afifah Adlina , Ismawati Ismawati , Irasanti Siska Nia 
Published: August 2021

Sif kerja merupakan hal yang umum di antara para pekerja. Sistem sif yang tidak teratur dan berkepanjangan dapat memengaruhi kesehatan pekerja dan produktivitasnya. Secara khusus, sif kerja dikenal sebagai hazard di tempat kerja karena dapat memengaruhi kualitas tidur pekerja. Kualitas tidur yang buruk akan berdampak buruk juga pada kesehatan dan keselamatan pekerja. Penelitian ini bertujuan menganalisis hubungan sif kerja dengan kualitas tidur pada pekerja di perusahaan Fast Moving Consumer Goods Karawang. Penelitian ini bersifat analitik dengan studi cross sectional pada 57 pekerja dengan menggunakan kuesioner Pittsburgh Sleep Quality Index (PSQI). Data diambil dengan menggunakan teknik purposive sampling pada pekerja di perusahaan FMCG Karawang tahun 2020. Data yang didapat dilakukan uji statistika dengan menggunakan uji Chi Square. Hasil penelitian menunjukkan kualitas tidur baik sebagian besar terdapat pada pekerja dengan sif pagi sebanyak 7 orang dan kualitas tidur buruk sebagian besar terdapat pada pekerja dengan sif malam sebanyak 18 orang. Hasil analisis didapatkan adanya hubungan antara sif kerja dan kualitas tidur pada pekerja di salah satu perusahaan FMCG Karawang (=0,023). Simpulan hasil penelitian menunjukkan terdapat hubungan antara sif kerja dan kualitas tidur. Correlation between Work Shift and Sleep Quality on Fast Moving Consumer Goods (FMCG) Company Workers in 2020Shift work is shared among workers. Irregular and prolonged shift systems can affect workers' health and productivity. In particular, shift work is known to be a workplace hazard. It may cause poor sleep quality, which can impact adversely on the health and safety of workers. This study aims to analyze the relationship between shift work and sleep quality in employees of the Fast Moving Consumer Goods Karawang companies. This study is an analytical study with a cross-sectional design on 57 workers through the Pittsburgh Sleep Quality Index (PSQI) questionnaire. The data were taken using a purposive sampling technique on FMCG Karawang companies in 2020. The data obtained were carried out by statistical tests using the Chi-Square test. The research results show that good sleep quality is mostly found in workers with morning shifts as many as seven people, and poor sleep quality is mostly found in workers with night shifts as many as 18 people. The analysis results showed a relationship between shift work and sleep quality in workers at FMCG Karawang companies (p = 0.023). The research results' conclusions indicate a significant relationship between shift work and sleep quality.
ECOLOGICAL VALUE OF KECAP PAMALI IN THE COMMUNITY OF KAMPUNG NAGA, TASIKMALAYA REGENCY
Authors: Gustiana Asep Deni , Supriatna Mamat 
Published: August 2021

People currently live in a modern and technological era, as a result, the local wisdom of an area is starting to erode. Even though there are many values contained in local wisdom that can be adopted and applied in an educational process. This article aims to describe comprehensively the results of the analysis of pamali soy sauce in the perspective of the people of Kampung Naga. In addition, this article discusses the ecological value contained in kecap pamali and the possibility of its culture in elementary school education. The method used is literature review and field study in the form of interviews and observations. The observations were made to see the behavior of the people of Kampung Naga related to kecap pamali.
La metáfora como mecanismo de inteligencia, creación y comunicación en ciencias duras e ingeniería y su recupero en la docencia universitaria
Authors: Magnasco Humberto Manuel 
Published: August 2021

<p>Presentamos una síntesis de nuestra investigación sobre la validez epistémica del recurso a la metáfora en educación superior como mecanismo de inteligencia, creación y comunicación en “ciencias duras” e ingeniería. La misma fraguó en una tesis de maestría en docencia universitaria en la que rastreamos la presencia del mecanismo metafórico en las producciones inaugurales y basales de la ciencia moderna (Galileo, Newton, Faraday, Maxwell, Fourier, Ohm). El método empleado fue cualitativo y de alcance exploratorio, descriptivo y genético, infiriendo desde indicadores empíricos el potencial de inteligencia, creación y comunicación del mecanismo. El diseño fue dialéctico, proponiendo matrices de datos que dieron coherencia y entidad epistémica a los mismos. Detectamos en el avance del conocimiento científico en esta etapa fundamental el uso <em>sine qua non</em> de creativas metáforas, que haciendo pie en los ámbitos “extranjeros” de la vida diaria y de disciplinas ajenas, permitieron inteligir creativamente fenómenos intrigantes y desafiantes. Constatamos que estos últimos, produciendo en el espíritu una especie de “vacío hermenéutico”, desafiaron al investigador y motorizaron un “llenado” creativo inicialmente metafórico (intentando conocer lo desconocido desde lo conocido). Dicha metáfora inicial - cognoscitivamente vívida e implicante- quedó luego disecada bajo un insípido ropaje matemático que la trocó en modelo. Concluimos que, si en la producción del conocimiento científico la metáfora ayudó creativamente a inteligir y matematizar los fenómenos, es oportuna su recuperación por parte de la docencia en orden a promover la construcción de los conocimientos científicos de una manera interesante y significativa. </p>
Dynamics of signs of granulomatous inflammation of the liver after administration of the BCG vaccine in mice of different ages
Authors: Nadeev A. P. , Abyshev A. A. , Ovsyanko E. V. , Kostina L. Yu. , Loginova A. B. 
Published: September 2021

Purpose of the study. The aim of the study was to study the morphogenesis of granulomatous inflammation in the liver in newborn animals and in remote periods of life.Materials and methods. The experiment was carried out on 70 newborn C57BL / 6 mice, divided into two groups. On the first day after birth, mice of the 1st (experimental) group were injected intraperitoneally with a solution of the BCG vaccine at a dose of 0.02 mg / kg. On the fi rst day of the beginning of the experiment, the mice of the 2nd (control) group were injected intraperitoneally with 0.02 ml of physiological solution. Liver samples were subjected to morphological and morphometric study: the body weight of mice (g), the volumetric density (Vv) of dystrophy and necrosis of hepatocytes, foci of extramedullary hematopoiesis, the number density (Nai) of binuclear hepatocytes, mitotic figures, the diameter of granulomas (μm), and the number density were calculated (Nai) granulomas in test area.Results. The introduction of the BCG vaccine to newborn mice on the 1st day led to a delay in their development and a lack of body weight. With the introduction of the BCG vaccine to newborn mice of the C57B1 / 6 line, a delayed formation of granulomas is noted, starting from the 10th day after the administration of the BCG vaccine, and a subsequent increase by 56 days in both the number and size of granulomas. The foci of extramedullary hematopoiesis in the liver of mice after the administration of the BCG vaccine persist for a longer period (up to 28 days), which is probably due to the participation of cells of the foci of hematopoiesis in the inflammatory process in the liver parenchyma. With the introduction of the BCG vaccine, pronounced destructive changes in hepatocytes in mice at all age periods are noted with reduced rates of reparative liver regeneration. Conclusion. The introduction of BCG vaccine to newborn mice led to the formation of tuberculous granulomas in the liver during the adult period of life with the development of destructive changes in hepatocytes and a reduced reparative ability of the liver.
Safety of epidural analgesia in an orthotopic liver transplantation
Authors: Shmakov A. N. , Elizar’eva N. L. , Kolosov A. N. , Gryaznov K. A. , Beloborodov K. Yu. , Kohno V. N. , Loktin E. M. , Budarov K. V. , Chekanov M. N. , Vereshchagin E. I. , Peshkova I. V. , Polyakevich A. S. 
Published: September 2021

In the literature devoted to the problems of liver transplantation, there is no clearly indicated attitude of the authors to intraoperative epidural blocks, although theoretically the benefits of a sympathetic block are considered. Some sources recommend prophylactic sodium bicarbonate infusion to alleviate post-reperfusion syndrome, but its effectiveness is questionable.Purpose: to present the physiological, biochemical and hematological characteristics of recipients at the stages of orthotopic liver transplantation with an assessment of the feasibility of using sodium bicarbonate for the prevention of reperfusion complications.Materials and methods. An observational study, contains an analysis of data from 39 participants operated on in 2020 in the volume of: hepatectomy, an orthotopic liver transplantation, with an initial assessment on the Child- Turcott- Pugh scale of 11 points. All participants were operated on under general inhalation anesthesia with sevoflurane and thoracic epidural three- component anesthesia according to the Breivik- Niemi method. There are 3 stages of data registration: the beginning of the anhepatic stage; the beginning of the neohepatic stage; the end of the operation.Results and discussion. Significant fluctuations in hemodynamics, violations of the acid-base state and energy metabolism were not revealed; a decrease in hepatic protein synthesis, a shift of the P50 point to the left, and moderate metabolic acidosis did not exceed the levels described in the literature. The dynamics of acidosis, РСО2 and natremia did not depend on the infusion of soda. There was no close correlation between arterial blood pH and lactate concentration.Conclusion. The benefits and safety of epidural anesthesia in orthotopic liver transplants are obvious and make it possible to recommend this component as a routine element of anesthesia during these operations. The indications for sodium bicarbonate infusion should be narrowed and consensus is needed to determine the critical pH value for sodium bicarbonate infusion.
The Potential of Marine Ecotourism in Pasumpahan Island Sungai Pisang Regency West Sumatera Province
Authors: Aris Pajri , Yoswaty Dessy , Mubarak Mubarak 
Published: September 2021

The aim of the study was to discover the potential level of pasumpahan island as destination for marine ecotourism. The method used was survey methods, data was consisting of primary and secondary data. Interviewing sampling method was used purposively, particularly for tourist sample for local Beach has a big potential in marine tourism and prossess a big chance to develop in marine ecotourism sector. It was showed by the suitability value of marine ecotourism development. The value was resulted through tourism proponent criteria, total scores of IKW and SWOT analysis
Pengaruh Pemberian Probiotik terhadap Laju Pertumbuhan dan Kelulushidupan Belut (Monopterus albus) pada Sistem Bioflok
Authors: Firdani Ardian Putra , Pamukas Niken Ayu , Tang Usman M. 
Published: September 2021

Belut (Monopterus albus) adalah komoditas perikanan air tawar yang bernilai ekonomi cukup tinggi, permintaan pasar yang tinggi namun ketersediaannya di alam mulai sulit ditemukan maka perlu melakukan peningkatan produksinya. Salah satu upaya yang dapat dilakukan adalah intensifikasi budidaya belut dengan sistem bioflok. Tujuan dari penelitian ini adalah untuk menentukan dosis probiotik terbaik yang ditambahkan ke media pemeliharaan, dalam meningkatkan volume flok, pertumbuhan dan kelulushidupan belut. Penelitian ini dilaksanakan pada bulan Juni hingga Juli 2020, bertempat di UPT Kolam Percobaan Fakultas Perikanan dan Kelautan Universitas Riau. Hewan uji yang digunakan adalah belut yang berukuran 10-15 cm dengan lama pemeliharaan 40 hari. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) satu faktor yang terdiri dari lima taraf perlakuan dengan tiga kali ulangan sehingga diperlukan 15 unit percobaan Taraf perlakuan yang digunakan pada penelitian ini sebagai berikut: P0 (Tanpa diberi probiotik boster sel multi 0 ml/L air), P1 (Dosis probiotik boster sel multi 0,6 mL/L air), P2 (0,9 mL/L air), P3 (1,2 mL/L air) dan P4 (1,5 mL/L air). Hasil penelitian menunjukkan bahwa pemberian probiotik pada media pemeliharaan belut memberikan pengaruh terhadap pertumbuhan dan kelulushidupan belut. Dosis 0,9 mL/L memberikan hasil terbaik terhadap pertumbuhan bobot multak, laju pertumbuhan spesifik, panjang mutlak, tingkat kelulushidupan masing masing sebesar 18,91 g, 3,59%, 15,53 cm, dan 75,55%. Selanjutnya kualitas air selama penelitian masih dapat ditoleransi oleh belut, seperti suhu berkisar antara 26-30oC, pH 5-7, DO 6,0-7,4 mg/L, dan NH3 0,00001-0,0005 mg/L.
Sistem Pendukung Keputusan Pemilihan Transportasi Online Dengan Metode Simple Additive Weighting
Authors: Aryasa Devara Putra , Pakereng Magdalena Ariance Ineke 
Published: September 2021

Penelitian ini bertujuan untuk mengetahui apakah masyarakat citayam lebih sering menggunakan gojek atau grab. Dengan menggunakan metode SAW (Simple Additive Weighting) sebagai metode yang digunakan untuk menyelesaikan permasalahan yang di alami, dengan melakukan menyebarkan kuesioner ke masyarakat Citayam. Penelitian ini dilakukan untuk mengetahui dan membandingkan tingkat peminat customer daerah citayam dalam memilih gojek dan grab. Dalam hal ini masyarakat mayoritas memilih grab dari pada gojek, bahwa gojek harus ditingkatkan karena memiliki nilai preferensi 0.94 dan grab memiliki nilai preferensi yaitu 0.95
CLONING OF SHRNA SEQUENCE SPECIFIC TO ELASTASE OF MACROPHAGES INTO EXPRESSION VECTOR PGPV-17019250
Authors: Bondar V. , Mezencev A. 
Published: September 2021

BACKGROUND: Macrophage elastase/MMP12 is one of the most important matrix metalloproteinase that cells secrete into the extracellular space. Secreted and activated MMP12 is capable to digest the proteins of extracellular matrix, such as fibronectin, laminin and elastin, facilitating the migration of immune cells to the inflamed tissue.
AIM: The aim of our study was to create a vector that would express a specific small interfering RNA (shRNA) to suppress the expression of human macrophage elastase.
METHODS: The online tool "siRNA Wizard" was used to design cDNA encoding shRNA specific to human macrophage elastase. The restriction endonucleases BamH1 and EcoRI, as well as a commercial T4 DNA ligase we used to clone the named cDNA into the expression vector pGPV-17019250. The presence of the cDNA in the vector was confirmed by PCR and DNA-sequencing with vector-specific primers.
RESULTS: In this study, we obtained the sequence of cDNA, encoding shRNA specific to macrophage elastase. We also cloned the named cDNA into the expression vector pGPV-17019250 and confirmed its exact location in the vector.
CONCLUSION: The generated expression vector pGPV-17019250-EM designated to suppress human macrophage elastase in cultured cells.
MECHANISMS OF THE THERAPEUTIC EFFECT OF HYPERBARIC OXYGEN ON THE GAS EXCHANGE FUNCTION OF THE LUNGS IN SARS-CO-2-ASSOCIATED PNEUMONIA
Authors: Savilov P. 
Published: September 2021

The article discusses some mechanisms of the therapeutic effect of hyperbaric oxygenation in COVID-19:
the effect of hyperbaric oxygen on the contractility of endotheliocytes of pulmonary capillaries, thrombogenic and arthrombogenic potential of pulmonary vessels.
The role of atorvastatin in collateral circulation formation induced by encephaloduroarteriosynangiosis: a prospective trial
Authors: Wang Qian-Nan , Bao Xiang-Yang , Zou Zheng-Xing , Wang Xiao-Peng , Zhang Qian , Li De-Sheng , Zhao Ya-Qun , Duan Lian 
Published: September 2021

OBJECTIVE
This prospective study was designed to confirm the role of atorvastatin in collateral circulation formation induced by encephaloduroarteriosynangiosis (EDAS) in patients with moyamoya disease (MMD).

METHODS
Patients who were diagnosed with MMD at the Department of Neurosurgery in the Fifth Medical Center of Chinese PLA General Hospital, Beijing, China, between June 2017 and May 2018 were included. Blood samples were obtained from an antecubital vein and were analyzed using flow cytometry. Endothelial progenitor cells (EPCs) were defined as CD34brCD133+CD45dimKDR+. All patients included in the study underwent EDAS. Patients voluntarily chose whether to undergo atorvastatin treatment after EDAS. The correlation between atorvastatin and good postoperative collateral circulation was evaluated.

RESULTS
A total of 106 patients with MMD were included in this study. Fifty-three patients (50%) received atorvastatin treatment. The baseline characteristics did not display statistically significant differences between the atorvastatin-treated and non-atorvastatin groups. Seventy-eight (42.9%) of the 182 hemispheres investigated postoperatively were classified as grade A collateral circulation, 47 (25.8%) as grade B, and 57 (31.3%) as grade C. Multivariate analysis revealed that only atorvastatin was significantly correlated with good collateral circulation after EDAS (p = 0.041).

CONCLUSIONS
The results of this prospective clinical trial have indicated that atorvastatin administered at 20 mg daily is safe and effective for the formation of postoperative collateral induced by EDAS.