bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacokinetics and tissue distribution of cantharidin after oral administration of aqueous extracts from Mylabris in rats
Authors: Duan Cancan , Cheng Weina , Chen Qihong , Li Xiaofei , Zhang Jianyong 
Published: May 2021

AbstractA sensitive gas chromatography–mass spectroscopy method was established for the determination of cantharidin (CTD) in rat plasma and liver homogenates. During the experiment, rats were randomly divided into two groups (low, high) and were administered aqueous extract of Mylabris compound for 7 days. Then, plasma and tissue samples were taken at different time points to study the pharmacokinetics and tissue distribution of CTD in rats. The selected reaction monitoring transitions for CTD and clofibrate (internal standard) were m/z 128 → 85 and m/z 169 → 141, respectively. The calibration curve ranged from 10.26 to 3,078 ng/ml for plasma and from 10.26 to 246.24 ng/ml for liver homogenates. The lower limits of quantification were 10.26 ng/ml for both plasma and liver. The intra‐ and inter‐day precision and accuracy were <20% for both plasma and liver homogenates. Extraction recovery ranged from 89.21 to 103.61% for CTD in rat plasma and liver and from 83.79 to 102.74% for IS in rat plasma and liver. Matrix effects ranged from 93.06 to 110.44% for CTD and from 91.65 to 110.80% for IS.
Emplacing linked lives: A qualitative approach to understanding the co‐evolution of residential mobility and place attachment formation over time
Authors: Bailey Etienne , Devine‐Wright Patrick , Batel Susana 
Published: May 2021

AbstractDespite growing interest in issues of residential mobility and place attachment in a globalised world, research within Environmental and Community psychology has tended to overlook the ways that interpersonal relations, and wider socio‐political and economic structural factors inform place attachment formation amongst residentially mobile individuals. We address this gap drawing on the Human Geography concept of ‘Linked Lives’ (Coulter et al., Progress in Human Geography, 2016, 40(3), 352–374), to conceive the relocation decisions of residentially mobile individuals, and their place (non)attachment to the current residence place, as deeply intertwined with formative place experiences, interpersonal relations, and the structural contexts within which people live (Coulter et al., Progress in Human Geography, 2016, 40(3), 352–374). With the aim of deepening understanding of the co‐evolution of residential mobility and place attachment, this paper presents narrative case studies of residents living in a town in Southwest England, with each resident indicating a different variety of people–place relations to their current residence place. Findings indicate that moving intentions and consequent residential place attachment result from complex interactions over time between (a) formative place experiences and settlement identities, leading to preferred types of residence place; (b) interpersonal relations with significant others including family and community members that vary according to life stage events; and (c) structural forces, comprising cultural, economic, and political factors shaping people's lives. Future research could examine how structural changes arising from the COVID‐19 pandemic are influencing residential mobilities and attachments to place.
Dual‐Knockout of Mutant Isocitrate Dehydrogenase 1 and 2 Subtypes Towards Glioma Therapy: Structural Mechanistic Insights on the Role of Vorasidenib
Authors: Poonan Preantha , Agoni Clement , Soliman Mahmoud E. S. 
Published: May 2021

AbstractRecently, Vorasidenib (AG‐881) has been reported as a therapeutic alternative that exerts potent dual inhibitory activity against mIDH1/2 towards the treatment of low‐grade glioma. However, structural and dynamic events associated with its dual inhibition mechanism remain unclear. As such, we employ integrative computer‐assisted atomistic techniques to provide thorough structural and dynamic insights. Our analysis proved that the dual‐targeting ability of AG‐881 is mediated by Val255/Val294 within the binding pockets of both mIDH1 and mIDH2 which are shown to elicit a strong intermolecular interaction, thus favoring binding affinity. The structural orientations of AG‐881 within the respective hydrophobic pockets allowed favorable interactions with binding site residues which accounted for its high binding free energy of −28.69 kcal/mol and −19.89 kcal/mol towards mIDH1 and mIDH2, respectively. Interestingly, upon binding, AG‐881 was found to trigger systemic alterations of mIDH1 and mIDH2 characterized by restricted residue flexibility and a reduction in exposure of residues to the solvent surface area. As a result of these structural alterations, crucial interactions of the mutant enzymes were inhibited, a phenomenon that results in a suppression of the production of oncogenic stimulator 2‐HG. Findings therefore provide thorough structural and dynamic insights associated with the dual inhibitory activity of AG‐881 towards glioma therapy.
Bewertung von Energieeffizienztechnologien mit der Methodik EDUAR&D an zwei Beispielen
Authors: Schäfer Bernhard , Toro Chacón Felipe Andrés , Brinkmann Thorsten , Drews Anja , Jochem Eberhard , Sauer Jörg 
Published: May 2021

AbstractDie Methodik EDUAR&D, kurz für Energiedaten und ‐analyse R&D, wird zur Bewertung von Energieeffizienztechniken genutzt. Es handelt sich um einen strukturierten Such‐ und Analyseprozess, der verschiedene methodische Ansätze zur Darstellung, Analyse und Bewertung der Techniken miteinander verbindet. Ziel ist es, Handlungsempfehlungen, z. B. bzgl. thematischer Schwerpunktsetzung, für die zukünftige Energieforschung im Rahmen der Forschungsförderung und für die Energiepolitik abzuleiten. Die Methodik wird hier am Beispiel der organophilen Nanofiltration und der Latentwärmespeicher vorgestellt.
A Small Molecule with Bridged Carbonyl and Tri‐fluoro‐aceto‐phenone Groups Impedes Microtubule Dynamics and Subsequently Triggers Cancer Cell Apoptosis
Authors: Mohapatra Saswat , Gupta Varsha , Mondal Prasenjit , Chatterjee Shreyam , Bhunia Debmalya , Ghosh Surajit 
Published: May 2021

AbstractWe identified a new microtubule targeted small molecule, which showed significant anticancer activity and induced apoptotic death of cancer cells. Precisely the central bridged carbonyl group and trifluoro‐acetophenone group of a bis‐benzothiazole molecule (BBT) interacts with tubulin close to the curcumin site and perturbs microtubule dynamics as well as causes microtubule depolymerization. We observed a significant enhancement of fluorescence while BBT interacts with the tubulin through bridged carbonyl moiety, a similar phenomenon to colchicine. Further, BBT activates tumor‐suppressing bim and p53‐puma axes to inhibit cancer survival. It also shows promising results against a tumor spheroid model. BBT is also capable of tumor regression, which shows that this molecule can serve as a potential template for the design of next‐generation microtubule targeted anticancer drugs.
On the undetectability of payloads generated through automatic tools: A human‐oriented approach
Authors: Carpentieri Bruno , Castiglione Arcangelo , Palmieri Francesco , Pizzolante Raffaele 
Published: May 2021

AbstractNowadays, several tools have been proposed to support the operations performed during a security assessment process. In particular, it is a common practice to rely on automated tools to carry out some phases of this process in an automatic or semiautomatic way. In this article, we focus on tools for the automatic generation of custom executable payloads. Then, we will show how these tools can be transformed, through some human‐oriented modifications on the generated payloads, into threats for a given asset's security. The danger of such threats lies in the fact that they may not be detected by common antivirus (AVs). More precisely, in this article, we show a general approach to make a payload generated through automated tools run undetected by most AVs. In detail, we first analyze and explain most of the methods used by AVs to recognize malicious payloads and, for each one of them, we outline the relative strengths and flaws, showing how these flaws could be exploited using a general approach to evade AVs controls, by performing simple human‐oriented operations on the payloads. The testing activity we performed shows that our proposal is helpful in evading virtually all the most popular AVs on the market. Therefore, low‐skilled malicious users could easily use our approach.
Stakeholder engagement and firms' innovation: Evidence from LGBT‐supportive policies
Authors: Kyaw Khine , Treepongkaruna Sirimon , Jiraporn Pornsit 
Published: May 2021

AbstractThere is a paucity of research on the effects corporate policies have on fostering innovative activities in firms, while research and development (R&D) investments offer a source of innovations in firms. Using governance data from Kinder, Lyndenberg, and Domini, Research and Analytics, Inc., R&D and financial data from Compustat, and market data from CRSP during the period from 1996 through 2011 this paper investigates whether Lesbian, Gay, Bisexual and Transgender (LGBT) ‐supportive corporate policies promote innovative activities in US firms. To the extent that LGBT–friendly policies allow inclusive working environments and therefore attract and retain talents, corporate can engage more in innovative activities. The findings show that firms with LGBT–supportive policies nurture employees' commitment to the firms and engage more in innovative activities. Heckman selection model, propensity score matching and difference‐in‐difference results all confirm the main findings from instrumental variable (IV) analyses.
NiIII‐rich NiFeBa as an Efficient Catalyst for Water Oxidation
Authors: Zhang Peili , Song Tao , Zheng Dehua , Li Fusheng , Wu Xiujuan , Fan Ke , Sun Licheng 
Published: May 2021

AbstractElectrocatalytic water oxidation requires efficient catalysts to reduce the overpotential and accelerate the sluggish kinetics of oxygen formation. Here, a promising NiFeBa material was prepared by the co‐electrodeposition of Ba2+, Ni2+, and Fe3+ as an efficient catalyst for electrocatalytic water oxidation. NiFeBa showed enhanced water oxidation performance compared with NiFe layered double hydroxide and NiFe oxide, delivering a current density of 10 mA cm−2 at an overpotential of 180 mV. Doped Ba ions played a key role in stabilizing the electrogenerated Ni3+ species, producing more octahedral Ni−O structures for lattice oxygen‐based water oxidation, adjusting the catalytic mechanism, and finally leading to an enhancement of catalytic efficiency.
Log reduction of leukemic cells and minimal residual disease by flow cytometry represent effective predictors of clinical outcome in elderly patients with acute myeloid leukemia
Authors: Rossi Giovanni , Giambra Vincenzo , de Waure Chiara , Giacchetta Irene , Minervini Maria Marta , Abbenante Maria Chiara , Spadano Raffaele , La Torre Antonella , Scalzulli Potito Rosario , Cascavilla Nicola 
Published: May 2021

AbstractBackgroundNowadays minimal residual disease (MRD) and log‐reduction of leukemic cells are poorly investigated in elderly patients with acute myeloid leukemia (AML) treated with hypometilating agents (HMAs). Studies focusing on MRD in elderly AML patients who received HMAs are scant and devoid of rigorous criteria for both enrollment and monitoring. Log‐reduction has never been investigated in these patients. Thus, the purpose of our study was to compare the prognostic impact of MRD and log‐reduction of leukemic cells at the optimal time of assessment in older AML patients.MethodsElderly patients who completed at least six cycles of HMAs and showed suitable leukemia‐associated immunophenotypes (LAIPs) for the MRD and log‐reduction assessment by flow cytometry were enrolled in the study.ResultsAfter comparing the times of assessment C4 (4‐cycles) and C6 (6‐cycles), C6 has been chosen as optimal. Patients who achieved MRD negativity or 2‐log‐reduction of leukemic cells at C6 had a significantly longer DFS. Particularly, results of 2‐log‐reduction were confirmed a multivariate analysis. Patients with MRD negativity or 2‐log reduction of leukemic cells showed an improvement of their OS, although not significantly.ConclusionsOur data confirmed the predictive role of MRD and 2‐log reduction also in older AML patients treated with HMAs.
Understanding rosacea‐prone skin: Understanding the correlations between clinical manifestations and underlying pathophysiology
Authors: Del Rosso James Q. 
Published: May 2021

AbstractOver the past two decades, our understanding of the pathophysiology of rosacea has increased dramatically. As a result, a rational overall management approach can be planned by the clinician based on the individual clinical manifestations affecting the patient. The improved understanding of the pathophysiologic mechanisms of the disease and the modes of action of many of the available therapies that can be used to treat rosacea provides the clinician with the ability to provide targeted treatments and incorporate scientifically sound therapeutic combinations. This article reviews the current understanding of rosacea pathophysiology, its correlation with specific clinical manifestations of rosacea, and appropriate selection of therapies to address these individual clinical manifestations.
Outcomes in patients with anthracycline‐induced cardiomyopathy undergoing left ventricular assist devices implantation
Authors: Guha Avirup , Caraballo Cesar , Jain Prantesh , Miller P. Elliott , Owusu‐Guha Jocelyn , Clark Katherine A.A. , Velazquez Eric J. , Ahmad Tariq , Baldassarre Lauren A. , Addison Daniel , Weintraub Neal L. , Desai Nihar R. 
Published: May 2021

AbstractAimsImproved cancer survivorship has led to a higher number of anthracycline‐induced cardiomyopathy patients with end‐stage heart failure. We hypothesize that outcomes following continuous‐flow LVAD (CF‐LVAD) implantation in those with anthracycline‐induced cardiomyopathy are comparable with other aetiologies of cardiomyopathy.Methods and resultsUsing the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) from 2008 to 2017, we identified patients with anthracycline‐induced cardiomyopathy who received a CF‐LVAD and compared them with those with idiopathic dilated (IDM) and ischaemic cardiomyopathies (ICM). Mortality was studied using the Cox proportional hazards model. Other adverse events were evaluated using competing risk models. Overall, 248 anthracycline‐induced cardiomyopathy patients underwent CF‐LVAD implantation, with a median survival of 48 months, an improvement compared with those before 2012 [adjusted hazards ratio (aHR): 0.53; confidence interval (CI): 0.33–0.86]. At 12 months, 85.1% of anthracycline‐induced cardiomyopathy, 86.0% of IDM, and 80.2% of ICM patients were alive (anthracycline‐induced cardiomyopathy vs. IDM: aHR: 1.12; CI: 0.88–1.43 and anthracycline‐induced cardiomyopathy vs. ICM: aHR: 0.98; CI: 0.76–1.28). Anthracycline‐induced cardiomyopathy patients had a higher major bleeding risk compared with IDM patients (aHR: 1.23; CI: 1.01–1.50), and a lower risk of stroke and prolonged respiratory support compared to ICM patients (aHR: 0.31 and 0.67 respectively; both P < 0.05). There was no difference in the risk of major infection, acute kidney injury, and venous thromboembolism.ConclusionsAfter receiving a CF‐LVAD, survival in patients with anthracycline‐induced cardiomyopathy is similar to those with ICM or IDM. Further research into differential secondary endpoints‐related disparities is warranted.
Techno‐economic optimization of a grid‐connected hybrid energy system considering electric and thermal load prediction
Authors: Qiu Ting , Faraji Jamal 
Published: May 2021

AbstractOptimal planning of hybrid energy systems has always been a considerable task. While several studies have conducted techno‐economic analysis on hybrid energy systems, most of them have neglected to consider appropriate electric and thermal load growth rates. This paper proposes an efficient strategy for optimizing a grid‐connected hybrid energy system considering electric and thermal load growth rates. HOMER software is used for optimizing hybrid energy systems. It uses a nonderivative optimization to recognize the system with the minimum net present cost (NPC) among hundreds of configurations. The exponential smoothing method is also used for predicting upcoming load peak values based on historical data. The proposed hybrid system includes solar photovoltaic (SPV) system, wind turbine (WT) system, converter, battery storage system (BSS), gas generator (GasGen), fuel cell (FC), fuel‐fired boiler, and resistive boiler. Unlike previous studies, electricity price growth and SPV degradation rates are considered in this study. The grid‐connected system has also been compared to the stand‐alone system to understand grid connection impacts on the optimization results. Environmental analysis has been performed to analyze the greenhouse gas emissions of each system. The effects of growth rates in thermal and electric loads and electricity price are comprehensively investigated. Neglecting load growth rates affected the financial results severely. In this condition, the NPC and COE are achieved −11 383.4 US$ and −0.02376 US$/kWh. Results indicate that the combination of WT system (15 kW), converter (10 kW), resistive, and fuel‐fired (10 kW) boilers is the most economical configuration in grid‐connected mode. The WT system plays an essential role in the electric power provision and revenues of the hybrid system. The net present cost (NPC) and the cost of energy (COE) for grid‐connected operating mode are achieved −0.0162272 US$/kWh and −5243.956 US$, respectively. For off‐grid operating mode, the NPC and COE are obtained 47 024.19 US$ and 0.1983879 US$/kWh, respectively. Thanks to the feed‐in‐tariff (FiT) policy, the proposed grid‐connected system is more economical and environmentally friendly than the stand‐alone system. In off‐grid operating mode, 63 575.45285 kg CO2 is produced, which is higher than CO2 production in the grid‐connected mode (more than 8262 kg).
Optical genome mapping, a promising alternative to gold standard cytogenetic approaches in a series of acute lymphoblastic leukemias
Authors: Lestringant Valentin , Duployez Nicolas , Penther Dominique , Luquet Isabelle , Derrieux Coralie , Lutun Anne , Preudhomme Claude , West Michaela , Ouled‐Haddou Hakim , Devoldere Catherine , Marolleau Jean‐Pierre , Garçon Loïc , Jedraszak Guillaume , Ferret Yann 
Published: May 2021

AbstractAcute lymphoblastic leukemias (ALL) are characterized by a large number of cytogenetic abnormalities of clinical interest that require the use of several complementary techniques. Optical genome mapping (OGM) is based on analysis of ultra‐high molecular weight DNA molecules that provides a high‐resolution genome‐wide analysis highlighting copy number and structural anomalies, including balanced translocations. We compared OGM to standard techniques (karyotyping, fluorescent in situ hybridization, single nucleotide polymorphism‐array and reverse transcription multiplex ligation‐dependent probe amplification) in 10 selected B or T‐ALL. Eighty abnormalities were found using standard techniques of which 72 (90%) were correctly detected using OGM. Eight discrepancies were identified, while 12 additional anomalies were found by OGM. Among the discrepancies, four were detected in raw data but not retained because of filtering issues. However, four were truly missed, either because of a low variant allele frequency or because of a low coverage of some regions. Of the additional anomalies revealed by OGM, seven were confirmed by another technique, some of which are recurrent in ALL such as LMO2‐TRA and MYC‐TRB fusions. Despite false positive anomalies due to background noise and a case of inter‐sample contamination secondarily identified, the OGM technology was relatively simple to use with little practice. Thus, OGM represents a promising alternative to cytogenetic techniques currently performed for ALL characterization. It enables a time and cost effective analysis allowing identification of complex cytogenetic events, including those currently inaccessible to standard techniques.
COVID‐19 and Pregnancy: A Case Study
Authors: Long Rui , Wu Di , Lin Xingguang , Lv Dan , Wang Renjie , Jin Lei , Liao Shujie , Liu Weiliang , Deng Dongrui 
Published: May 2021

AbstractThe 2019 novel coronavirus disease is spreading all over the world. Pregnant women and infants require particular concern, owing to the special immune conditions. A case of a pregnant woman who was exposed to SARS‐CoV‐2 at 34+1 weeks gestation and chose to continue pregnancy is reported. Without obvious symptoms or signs, the woman did not receive any treatment before delivery, and gave birth at 37+5 weeks to a neonate with positive immunoglobulin G for SARS‐CoV‐2 and negative nucleic acid tests. The mother was given anti‐infection, oxytocin, and fluid rehydration treatment after delivery. Both mother and infant recovered well after a three‐month follow‐up. Continued expectation to deliver at term instead of preterm can decrease the potential risk of severe perinatal and infant complications and is beneficial to the development of the neonate. More studies are required to confirm the presence of vertical transmission.
The interplay of resting and inhibitory control‐related theta‐band activity depends on age
Authors: Pscherer Charlotte , Bluschke Annet , Mückschel Moritz , Beste Christian 
Published: May 2021

AbstractResting‐state neural activity plays an important role for cognitive control processes. Regarding response inhibition processes, an important facet of cognitive control, especially theta‐band activity has been the focus of research. Theoretical considerations suggest that the interrelation of resting and task‐related theta activity is subject to maturational effects. To investigate whether the relationship between resting theta activity and task‐related theta activity during a response inhibition task changes even in young age, we tested N = 166 healthy participants between 8 and 30 years of age. We found significant correlations between resting and inhibitory control‐related theta activity as well as behavioral inhibition performance. Importantly, these correlations were moderated by age. The moderation analysis revealed that higher resting theta activity was associated with stronger inhibition‐related theta activity in individuals above the age of ~10.7 years. The EEG beamforming analysis showed that this activity is associated with superior frontal region function (BA6). The correlation between resting and superior frontal response inhibition‐related theta activity became stronger with increasing age. A similar pattern was found for response inhibition performance, albeit only evident from the age of ~19.5 years. The results suggest that with increasing age, resting theta activity becomes increasingly important for processing the alarm/surprise signals in superior frontal brain regions during inhibitory control. Possible causes for these developmental changes are discussed.