bluuebunny/crossref_metadata_2025_split huggingface dataset:
The objects and effects of non-party intervention before the International Court of Justice
Authors: Crespi Reghizzi Zeno 
Published: December 2021

AbstractThe International Court of Justice recognized the legitimacy of ‘non-party intervention’ under Article 62 of the Statute in its 1990 landmark decision on Nicaragua’s intervention in the Land, Island and Maritime Frontier Dispute (El Salvador v. Honduras). Such form of intervention ‘is not intended to enable a third State to tack on a new case, to become a new party, and so have its own claims adjudicated by the Court’. Its purpose is ‘protecting a State’s “interest of a legal nature” that might be affected by a decision in an existing case’. Whereas non-party intervention under Article 62 now forms part of the law in action within the Court’s system, its precise features and regime remain uncertain. Doubts concern the identification of its precise objects and the potential binding effects for a non-party intervener of the judgment issued between the original parties. The present article explores these issues in the light of the Court’s case law and state practice. It demonstrates that non-party intervention can have various potential objects, depending on how the intervener intends to influence the future judgment between the original parties. Building on the identification of these objects, it then questions the traditional construction denying any binding effect of the decision for a non-party intervener and argues that a judgment issued following intervention is binding as between the original parties and the intervener in so far as this judgment, whether expressly or by implication, decides issues related to the object of intervention.
Factors associated with breast-feeding initiation and continuation in Canadian-born and non-Canadian-born women: a multi-centre study
Authors: Chooniedass Rishma , Tarrant Marie , Turner Sarah , Lok Fan Heidi Sze , Del Buono Katie , Masina Stephanie , Becker Allan B , Mandhane Piushkumar , Turvey Stuart E , Moraes Theo , Sears Malcolm R , Subbarao Padmaja , Azad Meghan B 
Published: December 2021

AbstractObjective:To identify factors associated with breast-feeding initiation and continuation in Canadian-born and non-Canadian-born women.Design:Prospective cohort of mothers and infants born from 2008 to 2012: the Canadian Healthy Infant Longitudinal Development (CHILD) Cohort Study.Setting:General community setting in four Canadian provinces.Participants:In total, 3455 pregnant women from Vancouver, Edmonton, Winnipeg and Toronto between 2008 and 2012.Results:Of 3010 participants included in the current study, the majority were Canadian-born (75·5 %). Breast-feeding initiation rates were high in both non-Canadian-born (95·5 %) and Canadian-born participants (92·7 %). The median breast-feeding duration was 10 months in Canadian-born participants and 11 months in non-Canadian-born participants. Among Canadian-born participants, factors associated with breast-feeding initiation and continuation were older maternal age, higher maternal education, living with their partner and recruitment site. Rooming-in during the hospital stay was also associated with higher rates of breast-feeding initiation, but not continuation at 6-month postpartum. Factors associated with non-initiation of breast-feeding and cessation at 6-month postpartum were maternal smoking, living with a current smoker, caesarean birth and early-term birth. Among non-Canadian-born participants, maternal smoking during pregnancy was associated with lower odds of breast-feeding initiation and lower odds of breast-feeding continuation at 6 months, and older maternal age and recruitment site were associated with breast-feeding continuation at 6 months.Conclusions:Although Canadian-born and non-Canadian-born women in the CHILD cohort have similar breast-feeding initiation rates, breast-feeding initiation and continuation are more strongly associated with socio-demographic characteristics in Canadian-born participants. Recruitment site was strongly associated with breast-feeding continuation in both groups and may indicate geographic disparities in breast-feeding rates nationally.
Resisting autocratization: the protest–repression nexus in Hong Kong's Anti-ELAB Movement
Authors: Tung Hans H. , Kasuya Yuko 
Published: December 2021

AbstractThis introductory essay outlines the core themes of the special issue on the rise and fall of Hong Kong's Anti-Extradition Law Amendment Bill Movement. In the essay, we highlight several theoretical and empirical contributions the featured papers make to our understanding of the protest–repression nexus from the onset of the movement to the imposition of the National Security Law. First, we describe the political and social contexts of the movement. Second, we present our empirical findings on Hong Kongers' political preferences. Finally, we highlight new research avenues arising from this special issue.
Voicing their choices: Advance care planning with adolescents and young adults with cancer and other serious conditions
Authors: Wiener Lori , Bedoya Sima , Battles Haven , Sender Leonard , Zabokrtsky Keri , Donovan Kristine A. , Thompson Lora M. A. , Lubrano di Ciccone Barbara B. , Babilonia Margarita Bobonis , Fasciano Karen , Malinowski Paige , Lyon Maureen , Thompkins Jessica , Heath Corey , Velazquez Denise , Long-Traynor Karen , Fry Abigail , Pao Maryland 
Published: December 2021

AbstractObjectivesTo determine whether engaging in advance care planning (ACP) using a formal tool, Voicing My CHOiCES (VMC), would alleviate adolescent and young adults (AYAs) anxiety surrounding ACP and increase social support and communication about end-of-life care preferences with family members and health care providers (HCPs).MethodsA total of 149 AYAs aged 18–39 years receiving cancer-directed therapy or treatment for another chronic medical illness were enrolled at seven US sites. Baseline data included prior ACP communication with family members and HCPs and measures of generalized anxiety, ACP anxiety, and social support. Participants critically reviewed each page of VMC and then completed three pages of the document. ACP anxiety was measured again immediately after the completion of VMC pages. One month later, participants repeated anxiety and social support measures and were asked if they shared what they had completed in VMC with a family member or HCP.ResultsAt baseline, 50.3% of participants reported that they previously had a conversation about EoL preferences with a family member; 19.5% with an HCP. One month later, 65.1% had subsequently shared what they wrote in VMC with a family member; 8.9% shared with an HCP. Most (88.6%) reported they would not have had this conversation if not participating in the study. No significant changes occurred in social support. There was an immediate drop in anxiety about EoL planning after reviewing VMC which persisted at 1 month. Generalized anxiety was also significantly lower 1 month after reviewing VMC.Significance of resultsHaving a document specifically created for AYAs to guide ACP planning can decrease anxiety and increase communication with family members but not necessarily with HCPs. Future research should examine ways ACP can be introduced more consistently to this young population to allow their preferences for care to be heard, respected, and honored, particularly by their healthcare providers.
Estimation of intrapulse modulation parameters of LPI radar under noisy conditions
Authors: Raja Kumari Chilukuri , Kakarla Hari Kishore , Subbarao K. 
Published: December 2021

AbstractLow probability of intercept (LPI) radars utilize specially designed waveforms for intra-pulse modulation and hence LPI radars cannot be easily intercepted by passive receivers. The waveforms include linear frequency modulation, nonlinear frequency modulation, polyphase, and polytime codes. The advantages of LPI radar are wide bandwidth, frequency variability, low power, and the ability to hide their emissions. On the other hand, the main purpose of intercept receiver is to classify and estimate the parameters of the waveforms even when the signals are contaminated with noise. Precise measurement of the parameters will provide necessary information about a threat to the radar so that the electronic attack or electronic warfare support system could take instantaneous counter action against the enemy. In this work, noisy polyphase and polytime coded waveforms are analyzed using cyclostationary (CS) algorithm. To improve the signal quality, the noisy signal is pre-processed using two types of denoising filters. The denoised signal is analyzed using CS techniques and the coefficients of spectral correlation density are computed. With this method, modulation parameters of nine types of waveforms up to −12 dB signal-to-noise ratio with an accuracy of better than 95% are extracted. When compared with literature values, it is found that the results are superior.
Sex specific associations between in utero exposure to persistent organic pollutants and allergy-related outcomes in childhood: The Rhea Mother–Child Cohort (Crete, Greece)
Authors: Margetaki Katerina , Alexaki Maria , Vittorakis Evangelos , Roumeliotaki Theano , Leventakou Vasiliki , Bempi Vicky , Chalkiadaki Georgia , Kyrtopoulos Soterios A. , Rantakokko Panu , Kiviranta Hannu , Stephanou Euripides G. , Kogevinas Manolis , Chatzi Leda , Vafeiadi Marina 
Published: December 2021

AbstractAccumulating evidence suggests that in utero exposures can influence the development of the immune system. Few studies have investigated whether prenatal exposure to persistent organic pollutants (POPs) is associated with allergy-related phenotypes in childhood, nor explored sex differences. We examined the association between prenatal exposure to POPs and offspring allergic outcomes in early and mid-childhood. We included 682 mother–child pairs from the prospective birth cohort Rhea. We measured dichlorodiphenyldichloroethylene (DDE), hexachlorobenzene (HCB) and 6 polychlorinated biphenyl (PCB) congeners in maternal first trimester serum. Parents completed the questionnaires adapted from the International Study on Asthma and Allergy in Childhood (ISAAC) for allergy-related phenotypes when their children were 4 and 6 years old. We used Poisson regression models to estimate Risk Ratios. Prenatal HCB was associated with increased risk for rhinoconjunctivitis at 6 years (RR (95% CI): 2.5; (1.3, 4.8) for a doubling in the exposure). Among girls, prenatal DDE was associated with increased risk for current wheeze, current asthma and current rhinoconjunctivitis at 4 years (RR (95%CI): 1.4 (0.8, 2.6), 1.6 (1.1, 2.4) and 1.8 (1.0, 3.3) and p-interaction = 0.035, 0.027 and 0.059, respectively), with increased risk for current rhinoconjunctivitis at 6 years (RR (95%CI): 1.7 (0.7, 3.8) and p-interaction = 0.028) and total PCBs were associated with increased risk for current eczema at 4 years (RR (95%CI): 2.1 (1.1, 4.2) and p-interaction = 0.028). In boys, prenatal DDE was associated with decreased risk for current wheeze and current asthma at 4 years. Our findings suggest that even low levels of exposure to POPs prenatally may affect the development of childhood allergy-related outcomes in a sex and age-specific manner.
Global Groundwater Modeling and Monitoring: Opportunities and Challenges
Authors: Condon Laura E. , Kollet Stefan , Bierkens Marc F. P. , Fogg Graham E. , Maxwell Reed M. , Hill Mary C. , Fransen Harrie‐Jan Hendricks , Verhoef Anne , Van Loon Anne F. , Sulis Mauro , Abesser Corinna 
Published: December 2021

AbstractGroundwater is by far the largest unfrozen freshwater resource on the planet. It plays a critical role as the bottom of the hydrologic cycle, redistributing water in the subsurface and supporting plants and surface water bodies. However, groundwater has historically been excluded or greatly simplified in global models. In recent years, there has been an international push to develop global scale groundwater modeling and analysis. This progress has provided some critical first steps. Still, much additional work will be needed to achieve a consistent global groundwater framework that interacts seamlessly with observational datasets and other earth system and global circulation models. Here we outline a vision for a global groundwater platform for groundwater monitoring and prediction and identify the key technological and data challenges that are currently limiting progress. Any global platform of this type must be interdisciplinary and cannot be achieved by the groundwater modeling community in isolation. Therefore, we also provide a high‐level overview of the groundwater system, approaches to groundwater modeling and the current state of global groundwater representations, such that readers of all backgrounds can engage in this challenge.
Comparison of Different Coupling Methods for Joint Inversion of Geophysical Data: A Case Study for the Namibian Continental Margin
Authors: Franz G. , Moorkamp M. , Jegen M. , Berndt C. , Rabbel W. 
Published: December 2021

AbstractIntegration of multiple geophysical data is a key practice to reduce model uncertainties and enhance geological interpretations. Electrical resistivity models resulting from inversion of marine magnetotelluric (MT) data, often lack depth resolution of lithological boundaries and distinct information for shallow model parts. This is due to the diffusive nature of electromagnetic fields, enhanced by deficient data sampling and model regularization during inversion. Thus, integrating data or models to constrain layer thicknesses or structural boundaries is an effective approach to derive better constrained and more detailed resistivity models. We investigate the different impacts of three cross‐gradient coupled constraints on 3D MT inversion of data from the Namibian passive continental margin. The three constraints are (a) coupling with a fixed structural density model; (b) coupling with satellite gravity data; (c) coupling with a fixed gradient velocity model. Here, we show that coupling with a fixed model (a and c) improves the resistivity model the most. Shallow conductors imaging sediment cover are confined to a thinner layer in the resulting resistivity models compared to the MT‐only model. Additionally, these constraints help to suppress vertical smearing of a conductive anomaly attributed to a fracture zone, and clearly show that the seismically imaged Moho is not accompanied by a change in electrical resistivity. All of these observations help to derive an Earth model, which will form the basis for future interpretation of the processes that lead to continental break‐up during the early Cretaceous.
Initial Results From the Oman Drilling Project Multi‐Borehole Observatory: Petrogenesis and Ongoing Alteration of Mantle Peridotite in the Weathering Horizon
Authors: Kelemen Peter B. , Leong James A. , Carlos de Obeso Juan , Matter Jürg M. , Ellison Eric T. , Templeton Alexis , Nothaft Daniel B. , Eslami Alireza , Evans Katy , Godard Marguerite , Malvoisin Benjamin , Coggon Jude A. , Warsi Nehal H. , Pézard Philippe , Choe Saebyul , Teagle Damon A. H. , Michibayashi Katsuyoshi , Takazawa Eiichi , Al Sulaimani Zaher ,   The Oman Drilling Project Science Team
Published: December 2021

AbstractThe Oman Drilling Project “Multi‐Borehole Observatory” (MBO) samples an area of active weathering of tectonically exposed peridotite. This article reviews the geology of the MBO region, summarizes recent research, and provides new data constraining ongoing alteration. Host rocks are partially to completely serpentinized, residual mantle harzburgites, and replacive. Dunites show evidence for “reactive fractionation,” in which cooling, crystallizing magmas reacted with older residues of melting. Harzburgites and dunites are 65%–100% hydrated. Ferric to total iron ratios vary from 50% to 90%. In Hole BA1B, alteration extent decreases with depth. Gradients in water and core composition are correlated. Serpentine veins are intergrown with, and cut, carbonate veins with measurable14C. Ongoing hydration is accompanied by SiO2addition. Sulfur enrichment in Hole BA1B may result from oxidative leaching of sulfur from the upper 30 m, coupled with sulfate reduction and sulfide precipitation at 30–150 m. Oxygen fugacity deep in Holes BA3A, NSHQ14, and BA2A is fixed by the reaction 2H2O = 2H2 + O2combined with oxidation of ferrous iron in serpentine, brucite, and olivine. fO2deep in Holes BA1A, BA1D, and BA4A is 3–4 log units above the H2O‐H2limit, controlled by equilibria involving serpentine and brucite. Variations in alteration are correlated with texture, with reduced, low SiO2assemblages in mesh cores recording very low water/rock ratios, juxtaposed with adjacent veins recording much higher ratios. The proportion of reduced mesh cores versus oxidized veins increases with depth, and the difference in fO2recorded in cores and veins decreases with depth.
Single-cell analysis of salt-induced hypertensive mouse aortae reveals cellular heterogeneity and state changes
Authors: Zhang Ka , Kan Hao , Mao Aiqin , Geng Li , Ma Xin 
Published: December 2021

AbstractElevated blood pressure caused by excessive salt intake is common and associated with cardiovascular diseases in most countries. However, the composition and responses of vascular cells in the progression of hypertension have not been systematically described. We performed single-cell RNA sequencing on the aortic arch from C57BL/6J mice fed a chow/high-salt diet. We identified 19 distinct cell populations representing 12 lineages, including smooth muscle cells (SMCs), fibroblasts, endothelial cells (ECs), B cells, and T cells. During the progression of hypertension, the proportion of three SMC subpopulations, two EC subpopulations, and T cells increased. In two EC clusters, the expression of reactive oxygen species-related enzymes, collagen and contractility genes was upregulated. Gene set enrichment analysis showed that three SMC subsets underwent endothelial-to-mesenchymal transition. We also constructed intercellular networks and found more frequent cell communication among aortic cells in hypertension and that some signaling pathways were activated during hypertension. Finally, joint public genome-wide association study data and our single-cell RNA-sequencing data showed the expression of hypertension susceptibility genes in ECs, SMCs, and fibroblasts and revealed 21 genes involved in the initiation and development of high-salt-induced hypertension. In conclusion, our data illustrate the transcriptional landscape of vascular cells in the aorta associated with hypertension and reveal dramatic changes in cell composition and intercellular communication during the progression of hypertension.
Demonstration of thermal modulation using nanoscale and microscale structures for ultralarge pixel array photothermal transducers
Authors: Zhang Jinying , Li Defang , Li Zhuo , Wang Xin , Yang Suhui 
Published: December 2021

AbstractLarge-pixel-array infrared emitters are attractive in the applications of infrared imaging and detection. However, the array scale has been restricted in traditional technologies. Here, we demonstrated a light-driven photothermal transduction approach for an ultralarge pixel array infrared emitter. A metal-black coating with nanoporous structures and a silicon (Si) layer with microgap structures were proposed to manage the thermal input and output issues. The effects of the nanoscale structures in the black coating and microscale structures in the Si layer were investigated. Remarkable thermal modulation could be obtained by adjusting the nanoscale and microscale structures. The measured stationary and transient results of the fabricated photothermal transducers agreed well with the simulated results. From the input view, due to its wide spectrum and high absorption, the black coating with nanoscale structures contributed to a 5.6-fold increase in the temperature difference compared to that without the black coating. From the output view, the microgap structures in the Si layer eliminated the in-plane thermal crosstalk. The temperature difference was increased by 340% by modulating the out-of-plane microstructures. The proposed photothermal transducer had a rising time of 0.95 ms and a falling time of 0.53 ms, ensuring a fast time response. This method is compatible with low-cost and mass manufacturing and has promising potential to achieve ultralarge-array pixels beyond ten million.
Dopamine and fear memory formation in the human amygdala
Authors: Frick Andreas , Björkstrand Johannes , Lubberink Mark , Eriksson Allison , Fredrikson Mats , Åhs Fredrik 
Published: December 2021

AbstractLearning which environmental cues that predict danger is crucial for survival and accomplished through Pavlovian fear conditioning. In humans and rodents alike, fear conditioning is amygdala-dependent and rests on similar neurocircuitry. Rodent studies have implicated a causative role for dopamine in the amygdala during fear memory formation, but the role of dopamine in aversive learning in humans is unclear. Here, we show dopamine release in the amygdala and striatum during fear learning in humans. Using simultaneous positron emission tomography and functional magnetic resonance imaging, we demonstrate that the amount of dopamine release is linked to strength of conditioned fear responses and linearly coupled to learning-induced activity in the amygdala. Thus, like in rodents, formation of amygdala-dependent fear memories in humans seems to be facilitated by endogenous dopamine release, supporting an evolutionary conserved neurochemical mechanism for aversive memory formation.
LAMTOR5-AS1 regulates chemotherapy-induced oxidative stress by controlling the expression level and transcriptional activity of NRF2 in osteosarcoma cells
Authors: Pu Youguang , Tan Yiao , Zang Chunbao , Zhao Fangfang , Cai Cifeng , Kong Lingsuo , Deng Hui , Chao Fengmei , Xia Ran , Xie Minghua , Ge Fangfang , Pan Yueyin , Cai Shanbao , Huang Dabing 
Published: December 2021

AbstractLong-noncoding RNAs (lncRNAs) play roles in regulating cellular functions. High-throughput sequencing analysis identified a new lncRNA, termed LAMTOR5-AS1, the expression of which was much higher in the chemosensitive osteosarcoma (OS) cell line G-292 than in the chemoresistant cell line SJSA-1. Further investigations revealed that LAMTOR5-AS1 significantly inhibits the proliferation and multidrug resistance of OS cells. In vitro assays demonstrated that LAMTOR5-AS1 mediates the interaction between nuclear factor erythroid 2-related factor 2 (NFE2L2, NRF2) and kelch-like ECH-associated protein 1 (KEAP1), which regulate the oxidative stress. Further mechanistic studies revealed that LAMTOR5-AS1 inhibited the ubiquitination degradation pathway of NRF2, resulting in a higher level of NRF2 but a loss of NRF2 transcriptional activity. High level of NRF2 in return upregulated the downstream gene heme oxygenase 1 (HO-1). Moreover, NRF2 controls its own activity by promoting LAMTOR5-AS1 expression, whereas the feedback regulation is weakened in drug-resistant cells due to high antioxidant activity. Overall, we propose that LAMTOR5-AS1 globally regulates chemotherapy-induced cellular oxidative stress by controlling the expression and activity of NRF2.