bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’effet d’un « déjà-là » sur la pratique d'un enseignant : le point de vue de la didactique clinique de l’EPS
Authors: Ben Jomaâ Ben Hsouna Hejer , Terrisse André 
Published: June 2021

Cette étude de cas s’attache à rendre compte de la logique singulière d’enseignement d'un sujet enseignant d’éducation physique et sportive (Terrisse, 2003) à travers la recherche des traces de son « déjà-là », qui renvoie à son histoire singulière de sujet (Carnus, 2009), dans son enseignement. L’objet est d’étudier en quoi l’enseignement de l’éducation physique et sportive (EPS) renvoie à une différenciation de référentiels conceptuels, didactiques et de pratiques enseignantes en fonction des ressources personnelles, traduites ici en termes d’expertise personnelle et de vécu antérieur, d'un enseignant dans une activité physique et sportive donnée (APS). L’analyse didactique comparée de deux enseignements contrastés pour un même sujet enseignant et l’étude de cas de son verbatim et de sa pratique (six séances, quatre entretiens) ont permis de rendre compte des fondements subjectifs de l’acte de transmission de savoir de cet enseignant au service d’un regard clinique sur l’acte professionnel.
A Monocyte-Orchestrated IFN-I–to–IL-4 Cytokine Axis Instigates Protumoral Macrophages and Thwarts Poly(I:C) Therapy
Authors: Guo Panpan , Yang Limin , Zhang Mengfan , Zhang Yuyan , Tong Yuanyuan , Cao Yanlan , Liu Jianghuai 
Published: June 2021

Abstract
Type I IFNs (IFN-I) are important for tumor immune surveillance and contribute to the therapeutic responses for numerous treatment regimens. Nevertheless, certain protumoral activities by IFN-I have been increasingly recognized. Indeed, our recent work showed that systemic poly(I:C)/IFN treatment can undesirably trigger high arginase (ARG1) expression within the tumor-associated monocyte/macrophage compartment. Using a line of CRISPR-generated Arg1-YFP reporter knock-in mice, we have determined that a subset of tumor-associated macrophages represent the major Arg1-expressing cell type following poly(I:C)/IFN stimulation. More detailed analyses from in vitro and in vivo models demonstrate a surprising IFN–to–IL-4 cytokine axis in transitional monocytes, which can subsequently stimulate IL-4 target genes, including Arg1, in macrophages. Intriguingly, IFN stimulation of transitional monocytes yielded concurrent M2 (YFP+)- and M1 (YFP–)-skewed macrophage subsets, correlated with an inhibitory crosstalk between IFN-I and IL-4. Genetic abrogation of IL-4 signaling in mice diminished poly(I:C)/IFN-induced ARG1 in tumors, leading to enhanced activation of CD8+ T cells and an improved therapeutic effect. The present work uncovered a monocyte-orchestrated macrophage phenotype conversion mechanism that may have broad implications.
CLec-TM1–ERK–GSK3β Pathway Regulates Vibrio splendidus–Induced IL-17 Production in Oyster
Authors: Sun Jiejie , Gao Lei , Huang Shu , Wang Lingling , Yang Wenwen , Zhang Tong , Jin Yingnan , Song Linsheng 
Published: June 2021

Abstract
C-type lectins are a family of pattern recognition receptors that recognize microbial components and subsequently activate the signaling cascade to induce the production of proinflammatory cytokines. In the current study, the homologs of ERK (named as CgERK) and GSK3β (named as CgGSK3β) and a novel C-type lectin with a transmembrane domain (named as CgCLec-TM1) were identified from oyster Crassostrea gigas. CgCLec-TM1 was able to bind Escherichia coli and Vibrio splendidus through its carbohydrate recognition domain and then activated CgERK by inducing its phosphorylation. The activated CgERK interacted with CgGSK3β to phosphorylate it at Ser9, which eventually induced the expressions of CgIL-17-1 and CgIL-17-5. The interaction between CgERK and CgGSK3β, as well as the phosphorylation of CgGSK3β, could be inhibited by ERK inhibitor (PD98059) to reduce the expressions of CgIL-17-1 and CgIL-17-5. CgGSK3β in oyster was proposed as a new substrate of CgERK. The results defined a CLec-TM1–ERK–GSK3β signaling pathway in oyster, which was activated by V. splendidus and then induced CgIL-17 productions.
Zebrafish Uba1 Degrades IRF3 through K48-Linked Ubiquitination to Inhibit IFN Production
Authors: Chen Dan-Dan , Jiang Jing-Yu , Lu Long-Feng , Zhang Can , Zhou Xiao-Yu , Li Zhuo-Cong , Zhou Yu , Li Shun 
Published: June 2021

Abstract
Fish IFN regulatory factor 3 (IRF3) is a crucial transcription factor in the IFN activation signaling pathway, which leads to IFN production and a positive cycle. Unrestricted IFN expression results in hyperimmune responses and therefore, IFN must be tightly regulated. In the current study, we found that zebrafish Ub-activating enzyme (Uba1) negatively regulated IRF3 via the K-48 ubiquitin proteasome degradation of IRF3. First, ifn expression stimulated by spring viraemia of carp virus infection was blunted by the overexpression of Uba1 and enhanced by Uba1 knockdown. Afterward, we found that Uba1 was localized in the cytoplasm, where it interacted with and degraded IRF3. Functional domains analysis revealed that the C-terminal ubiquitin-fold domain was necessary for IRF3 degradation by Uba1 and the N-terminal DNA-binding domain of IRF3 was indispensable for the degradation by Uba1.The degradation of IRF3 was subsequently impaired by treatment with MG132, a ubiquitin proteasome inhibitor. Further mechanism analysis revealed that Uba1 induced the K48-linked Ub-proteasomal degradation of IRF3. Finally, the antiviral capacity of IRF3 was significantly attenuated by Uba1. Taken together, our study reveals that zebrafish Uba1 interacts with and activates the ubiquitinated degradation of IRF3, providing evidence of the IFN immune balance mechanism in fish.
Assessment of oral health status and treatment needs in hemodialysis patients at Raichur district, Karnataka, India
Authors: Acharya Arun Kumar , Chinna Sudarshan Kumar , Bankur Rashmi , Margabandhu Shanthi , Babu B. Anil , Ismail Nasi 
Published: June 2021

Introduction:
According to the World Health Organization (WHO) global burden of disease project, chronic kidney disease is the 12th leading cause of death and 17th leading cause of disability in the world. Statistics show that 90% of the patients suffering from chronic renal failure face oral health-related problems. The objective of the study was to assess the oral health status and treatment needs in hemodialysis patients at Raichur district, Karnataka.

Materials and Methods:
A cross-sectional study was carried out on 110 patients undergoing hemodialysis at Raichur district, Karnataka. Oral health status was assessed using the WHO assessment form 1997. Oral Hygiene Index – Simplified (1964) was used to assess the Oral Hygiene Status.

Results:
The mean age of the patients was 43.99 ± 12.80 years and the mean Decayed Teeth, Missing Teeth, Filled Teeth (FT), and Decayed Missing FT was 2.53 ± 2.39, 4.39 ± 7.57, 0.08 ± 0.30, and 7.00 ± 7.01, respectively. The prevalence of dental caries was 94.5%. Calculus was seen in 60.9% of the patients. Oral hygiene status was poor in 49.5% of the patients. The mean number of teeth required treatment was 4.4.

Conclusion:
This special population has high prevalence of dental caries and poor oral hygiene which needed periodic health education and intervention.
Morphologic patterns of lip prints in a sample of Sudanese population
Authors: Haroun Andy Mohamed , Awooda Elhadi Mohieldin 
Published: June 2021

Background:
The outer surrounding surface of the lips has elevations, depressions, normal lines, and fissures in the form of wrinkles and grooves present in the zone of the transition of the lip which can be used in the identification of a person.

Aims:
The aim was to determine the predominant type of lip print among a sample of the Sudanese population and to assess the relation between lip print with age and gender.

Materials and Methods:
A descriptive cross-sectional study among 394 (150 males and 244 females) adult Sudanese participants living within the Khartoum city. Those with a history of lip injury, congenitally deformed lip, children, very old or coming from the eastern region were excluded. Red lipstick impression with a white chart paper in the normal rest position of the lips by dabbing it in the center first and then press it uniformly toward the corners. Lip print type was assessed according to Suzuki and Tsuchihashi's from type 1 to type V. Comparison between variables by Chi-Squire with the level of significance set at P value of <0.05.

Results:
Result showed a unique different type of lip print among peoples coming from different regions and different tribes in Sudan. Type I was predominantly among the studied population and the least was type V. The predominant type of lip print among those their origin is from the Northern was type I (32.6%), type II was among those from Southern (28.6%), and type I' among those from Western (33.3%). There was no statistical significance difference between the type of lip print among male and female or between different age groups.

Conclusion:
Type I' lip print pattern was most common type of lip print pattern among the studied population with no association between age or sex and lip print type. Increasing sample size and conducting the examination on participants from different regions in Sudan, can eliminate any confounding factors and gives valid and reliable findings.
Helicobacter pylori-associated gastritis phenotypes in a South-Western Nigerian population
Authors: Jemilohun Abiodun Christopher , Ajani Mustapha Akanji , Solaja Taiwo Olufemi , Uka Aaron ThankGod 
Published: June 2021

Background:
The long-term outcomes of Helicobacter pylori infection ultimately depend on the distribution and extent of gastritis. Three main types of gastritis phenotypes which include pangastritis, antral-predominant gastritis, and corpus-predominant gastritis have been observed. Corpus predominant gastritis is more common in the parts of Asia with a high prevalence of gastric adenocarcinoma. This study was conducted to determine the prevalence of H. pylori-associated gastritis phenotypes in a South-western Nigerian population, a sub-Saharan African population.

Materials and Methods:
The study was a cross-sectional prospective study which included 267 dyspeptic patients who had esophagogastroduodenoscopy at a tertiary health institution in South-west Nigeria. Five gastric biopsies were taken from each subject, and standard histologic examination was performed on the specimens. Both biopsy sampling and histologic examination followed the Updated Sydney System recommendations. The data generated were statistically analyzed. Continuous variables were presented as means ± standard deviation, whereas associations between the categorical variables were determined by the Pearson Chi-square test or Fisher's exact test. P ≤ 0.05 was considered statistically significant.

Results:
The mean age was 46.1 (±15.4) years while the age range was 16–84 years. There were 160 (59.9%) female and 107 (40.1%) male participants. All participants had histological gastritis, whereas 79 (29.6%) were positive for H. pylori by histology. H. pylori infection was significantly associated with peptic ulcer disease. Among those who had H. pylori infection, 51 (64.6%) had pangastritis, 26 (32.9%) had antral-predominant gastritis, while 2 (2.5%) had corpus-predominant gastritis. The relationship between H. pylori infection and the gastritis phenotypes showed no statistical significance.

Conclusion:
The prevalence of corpus predominant gastritis was low in our study population.
Comparison of Fibroscan with Liver biopsy in non-alcoholic fatty liver disease (NAFLD) patients for assessing fibrosis
Authors: Bhat Ganraj , Likitha S. R. , Krishnappa Rashmi , Agarwal Gaurav , Kiran Ravi , Nagesh Kumar T. C. 
Published: June 2021

Background:
The prevalence of nonalcoholic fatty liver disease (NAFLD) in India varies from 9 to 35%. NAFLD is one of the most common causes of chronic liver disease worldwide. Liver biopsy, which is the gold standard for diagnosing NAFLD is an invasive procedure with potential adverse effects and large inter- and intra-observer variability. Hence, various noninvasive markers are being explored to assist in the diagnosis of NAFLD. Fibroscan measures liver stiffness through estimation of the velocity of propagation of a shear wave through liver tissue. Very few studies have addressed the accuracy of fibroscan versus liver biopsy.

Objectives:
To grade liver fibrosis in the patients and compare fibrosis score by fibroscan with that of liver biopsy in NAFLD.

Materials and Methods:
An observational study of 72 subjects who had presented with fatty liver on ultrasound and further subjected to fibroscan at the outpatient department of gastroenterology and have undergone liver biopsy (gold standard) for confirmation in the Department of Pathology, Ramaiah Medical College. The study was done from January 2017 to December 2018. After routine processing, liver biopsies were categorized into four subgroups depending on the fibrosis score such as F1 (perivenular fibrosis), F2 (periportal fibrosis), F3 (bridging fibrosis), and F4 (cirrhosis) and was compared with fibroscan scoring, which was based on the degree of fibrosis.

Results:
Our study revealed that in the subgroup of NAFLD patients with F1, F2, F3 fibrosis on biopsy, the mean fibroscan values were 11.84 ± 9.23, 16.98 ± 18.85, 21.93 ± 5.85, respectively, which overestimate the fibrosis score (2.5–7.5 Kpa), (7.6–10 Kpa), (10.1–13 Kpa), respectively, and in F4 fibrosis, the mean fibroscan value was 33.41 ± 17.39 and in concordance with the fibrosis score (>13 Kpa).

Conclusion:
Fibroscan overestimates the fibrosis score in the early stages of NAFLD, whereas, it has high accuracy in detecting advanced fibrosis and cirrhosis. Hence, it can be concluded that transient elastography is a good adjunctive tool in NAFLD patients with advanced fibrosis.
Korelasi Antara Motivasi, Strategi Belajar, dan Prestasi Akademik Taruna ATKP Makassar: Tinjauan Belajar Level 4 Standard ICAO
Authors: Rossydi Ahmad , Erna Wahyu P. Agnes , Atbar Mustahrim 
Published: June 2021

Penelitian ini bertujuan untuk mengetahui korelasi antara motivasi, strategi belajar, dan prestasi akademik taruna ATKP Makassar: tinjauan belajar level 4 standard ICAO. Penelitian ini merupakan penelitian kuantitatf dengan sampel Taruna ATKP Makassar Prodi Lalu Lintas Udara dan Komunikasi Penerbangan dengan teknik pengambilan sampel acak (sampling). Pengumpulan data dengan menggunakan angket (kuesioner). Analisis data dilakukan dengan menggunakan analisis korelasi product Moment dari Pearson.Pada taraf signifikansi 5%, hasil penelitian menemukan bahwa: (1) motivasi belajar mempunyai korelasi positif terhadap strategi belajar dengan nilai r sebesar 0,851. (2) Motivasi belajar taruna mempunyai korelasi positif dengan prestasi akademik yang dalam penelitian inin adalah kecakapan Bahasa inggris dengan nilai r sebesar 0,892. (3) Strategi belajar bahasa mempunyai korelasi positif dengan prestasi akademik (kecakapan berbahasa inggris) dengan nilai r sebesar 0,802. Motivasi sebagai pemberi stimulus sementara strategi belajar mengarahkan dan memaksimalkan dorongan kearah yang lebih positif. Motivasi memunculkan rasa percaya diri yang sangat penting dalam pengembangan kecakapan berbahasa inggris. Strategi belajar dapat mengontrol keterbatasan-keterbatasan produksi Bahasa.
Analisis Pertumbuhan Penumpang di Bandar Udara Gamar Malamo Galela Kabupaten Halmahera Utara Provinsi Maluku Utara
Authors: Rahim Jamaluddin , Sabur Fatmawati 
Published: June 2021

Bandar Udara Gamar Malamo Galela perintis di Provinsi Maluku. Pelayanan penerbangan pada rute Ternate – Galela PP oleh PT. Merpati Nusantara Airlines menggunakan pesawat Twin Otter atau DHC-6, dengan frekuensi 3 kali seminggu. Penelitian ini merupakan penelitian non eksperimen dan studi kasus terhadap peningkatan permintaan jasa transportasi. Pengolahan data menggunakan pendekatan deskripsi kuanlitatif dan kuantitatif berdasarkan data sekunder melalui peramalan permintaan jumlah pergeakan pesawat. pengolahan data dengan program SPSS seri 22, peramalan proyeksi jumlah pergerakan penumpang. Hasil penelitian berdasarkan data time sires pada variabel pertumbuhan Penduduk menunjukkan Hasil Persamaan regresi liner nilai variable Y = 2232,5 + 2841,1 X, dengan koefIsien determinasi adalah R² = 0,653, sedangkan model Logaritmik dengan nilai Y = 3205,823+ Ln (7885,107X) dengan perolehan nilai determinasi R² = 0,813, Polynomial(cubic), dengan perolehan nilai persamaan Y = -20691,2 +29790,952 X – 8512,5 X2 +793,58 X3, dengan dinlai determinasi R² = 0,94, model eksponensial menghasilkan persamaan Y = 187,871 e0,213x dengan nilai detreminasi R2 = 0,603. Dimana Jumlah permintaan penumpang jasa transportasi udara di Bandar Udara Gamar Malamo pada tahun 2040 mencapai 238.179 orang
ANALISA POTENSI PASAR TERHADAP PRODUK OLAHAN TELUR DITINJAU DARI ASPEK PERMINTAAN PASAR
Authors: Utama Adiguna , Wardhani Shanti Ike , Normawati Rani Arifah 
Published: June 2021

Objektif. Wilayah Blitar Raya merupakan salah satu daerah penghasil telur di Indonesia dengan kontribusi sekitar 70% terhadap produksi telur Jawa Timur dan 30% produksi telur nasional. Penelitian ini bertujuan untuk melihat potensi pasar terhadap produk olahan telur ditinjau dari aspek permintaan pasar.
Material and Metode. Penelitian ini merupakan penelitian kualitatif dengan pendekatan market research. Subjek peneliian menggunakan produk olahan telur, sedangkan objeknya menggunakan konsumen produk telur di wilayah Jabodetabek dan Gerbang Kertasusila. Kuesioner dalam bentuk google form yang disebar menggunakan Whatsapp Group maupun media sosial lainnya.
Hasil. Hasil penelitian menunjukkan bahwa potensi pasar terkait dengan produk olahan telur memiliki pangsa pasar yang cukup baik dan menjanjikan. Hal ini dikarenakan permintaan pasar yang cukup tinggi terhadap produk olahan telur sehingga masih memiliki peluang dalam pengembangan usaha produk olahan telur di pasaran seiring berkembangnya dunia bisnis. Permintaan konsumen yang tinggi disebabkan oleh beberapa faktor seperti minat konsumen untuk mengkonsumsi produk, harga produk dan berbagai macama alasan ketertarikan dalam mengkonsumsi produk olahan telur.

Kesimpulan. Potensi pasar terhadap produk olahan telur masih memiliki peluang yang cukup besar dalam pnegembangannya dikarenakan permintaan konsumen masih tinggi. Oleh karena itu, perlu adanya usaha yang memunculkan inovasi dan kreativitas para produsen untuk menyajikan produk olahan telur dalam kemasan dan juga kualitas yang baik agar tetap bertahan di tengah persaingan dunia bisnis saat ini.
История художественного собрания Н.Е. Добычиной в послереволюционные годы: состав и проблемы бытования
Authors: Muromtseva O.V. 
Published: June 2021

Nadezhda Evseevna Dobychina, whose name is strongly associated with the Art Bureau, which operated in St. Petersburg (Petrograd) from 1911 to 1919, possessed a significant collection of works of art by her contemporaries. The central part of the collection consisted of the works of the artists of the “World of Art” (“Mir Iskusstva”) circle, as well as the associations “Blue Rose” and “Union of Russian Artists”. From the lists of the collection preserved in the Dobychina’s archive, made at the initiative of representatives of the Soviet state in 1919, 1924 and 1930, one can trace how the collection developed in the first post-revolutionary decade. Nadezhda Dobychina gave preference to figurative art, in her property there were practically no abstract works, and the leftist trends of the avant-garde were also not represented. Most of the works kept by Dobychina were graphics (watercolors, pencil drawings and charcoal sketches), however, it should be noted that a block of bright paintings, perfectly combined in style and color, stood out in her collection (“Dawn” by D.S. Stelletsky, “Heat” by M.S. Sariyan, “Portrait of Dobychina” by N.I. Altman and others). The collection changed over time, but its central part remained unchanged despite all the vicissitudes of the owner's eventful life.
Надежда Евсеевна Добычина, имя которой прочно ассоциируется с Художественным бюро, функционировавшим в Санкт-Петербурге (Петрограде) с 1911 по 1919 год, обладала значительной коллекцией художественных произведений своих современников. Центральное место в собрании занимали мастера круга «Мира искусства», а также объединений «Голубая роза» и «Союз русских художников». По сохранившимся в архиве Добычиной спискам коллекции, сделанным по инициативе представителей советской власти в 1919, 1924 и 1930 годах, можно проследить, как развивалось собрание в первое послереволюционное десятилетие. Надежда Добычина отдавала предпочтение фигуративному искусству, в ее собственности практически не было абстрактных работ, а также не представлены были левые течения авангарда. Большая часть произведений, хранимых Добычиной, — это графика (акварели, карандашные рисунки и наброски углем). Однако следует отметить, что в ее собрании выделялся блок ярких живописных работ, прекрасно сочетавшихся по стилю и колориту («Заря» Д.С. Стеллецкого, «Зной» М.С. Сарьяна, «Портрет Добычиной» Н.И. Альтмана и другие). Состав коллекции менялся с течением времени, но костяк ее оставался неизменным, несмотря на все перипетии богатого событиями жизненного пути владелицы.
Evaluación de cuatro extractos vegetales para el manejo de áfidos en el cultivo de loroco en los departamentos de Zacapa y Chiquimula, Guatemala
Authors: Morales Samayoa Abel Arturo , Suchini Sagastume David Enrique , Oliva Vargas José Carlos 
Published: June 2021

El loroco es un cultivo de gran importancia económica para el oriente del país, principalmente para los departamentos de Zacapa y Chiquimula. Una plaga común de este cultivo son los áfidos o pulgones, que al succionar la savia de las plantas generan un descenso en la producción de flores, lo cual afecta a los productores causando una menor producción. Usualmente esta plaga es tratada con agroquímicos e insecticidas sintéticos. En busca de una alternativa menos costosa y más amigable con la salud humana y el medio ambiente, se evaluó la capacidad insecticida y de control de áfidos de cuatro productos cuyo ingrediente principal son extractos vegetales: 1)Harzét® -05 81.85 (orégano), 2) Shardaneem® (Neem), 3) Striker® (tomillo) y 4) Pirex® EC (crisantemo con canela). Se manejaron cuatro tratamientos y un testigo absoluto en parcelas del cultivo, establecidas en tres diferentes localidades de los departamentos de Zacapa y Chiquimula. Para las pruebas se emplearon las dosis recomendadas por el fabricante, sin variantes. Adicionalmente se realizó un análisis económico parcial de los tratamientos. De los extractos evaluados, el Pirex® EC obtuvo el mejor resultado para control de incidencia de áfidos (±80%) con una residualidad ambiental menor de dos días.