bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collagen based electrospun materials for skin wounds treatment
Authors: Hernández‐Rangel A. , Martin‐Martinez E. San 
Published: February 2021

AbstractMaterials used for wound care have evolved from simple covers to functional wound dressings with bioactive properties. Electrospun nanofibers show great similarity to the natural fibrillar structure of skin extracellular matrix (ECM); therefore, by mimic, the morphology of ECM, nanofibers show high potential for facilitating the healing of skin injuries. Besides morphology, scaffold composition is another important parameter in the production of bioactive wound dressings. Collagen type I is the main structural protein of skin ECM is biocompatible, biodegradable, and its extraction from animal sources is relatively simple. The fabrication of electrospun wound dressings based on collagen and its blends have been studied for skin tissue engineering applications. This review focus on the new advances of collagen electrospun materials for skin wound treatment. It summarizes the recent research on pristine collagen, collagen blends, and collagen surface modifications on nanofibers mats. Finally, the strategies for three‐dimensional nanofibers production will also be discussed.
Predicting improvement of work ability in modalities of short‐ and long‐term psychotherapy: The differential impact of reflective ability and other aspects of patient suitability
Authors: Alanne Carita , Heinonen Erkki , Knekt Paul , Rissanen Julius , Virtala Esa , Lindfors Olavi 
Published: February 2021

AbstractObjectivesWe investigated how patients' psychological capacities to engage in psychotherapy predict changes in work ability in short‐ and long‐term psychotherapy.MethodsA cohort study of 326 patients, aged 20–46 years and suffering from mood and anxiety disorders, treated by short‐term solution‐focused, short‐term psychodynamic, or long‐term psychodynamic psychotherapy, followed‐up for 5 years. The Suitability for Psychotherapy Scale, assessed at baseline, was the predictor. Outcomes were assessed at baseline and at six follow‐up occasions using the Work Ability Index as the primary indicator.ResultsPatients with good pretreatment psychological suitability for psychotherapy, good reflective ability in particular, improved more than patients with poor suitability in short‐term psychodynamic psychotherapy. Comparisons between therapy groups showed poorer suitability to predict more improvement in solution‐focused and in long‐term psychodynamic psychotherapy than in short‐term psychodynamic psychotherapy.ConclusionPatients' psychological suitability for psychotherapy has a different impact on work ability in different therapy modalities and durations.
Feasibility and usability study of a pilot immersive virtual reality‐based empathy training for dental providers
Authors: Amini Homa , Gregory Megan E. , Abrams Mary Ann , Luna John , Roland Maxwell , Sova Lindsey N. , Bean Canise , Huang Yungui , Pfeil Sheryl A. , Townsend Janice , Lin En‐Ju D 
Published: February 2021

AbstractPurposeSocial determinants of health (SDOH) significantly impact individuals’ engagement with the healthcare system. To address SDOH‐related oral health disparities, providers must be equipped with knowledge, skills, and attitudes (KSAs) to understand how SDOH affect patients and how to mitigate these effects. Traditional dental school curricula provide limited training on recognizing SDOH or developing empathy for those with SDOH‐related access barriers. This study describes the design and evaluation of such a virtual reality (VR)‐based simulation in dental training. We hypothesize the simulation will increase post‐training KSAs.MethodsWe developed “MPATHI” (Making Professionals Able THrough Immersion), a scripted VR simulation where participants take the role of an English‐speaking caregiver with limited socioeconomic resources seeking dental care for a child in a Spanish‐speaking country. The simulation is a combination of 360° video recording and virtual scenes delivered via VR headsets. A pilot was conducted with 29 dental
residents/faculty, utilizing a pre‐post design to evaluate effectiveness in improving immediate and retention of KSAs toward care delivery for families facing barriers.ResultsMPATHI led to increased mean scores for cognitive (pre = 3.48 ± 0.80, post = 4.56 ± 0.51, p < 0.001), affective (pre = 4.20 ± 0.4, post = 4.47 ± 0.44, p < 0.001), and skill‐based learning (pre = 4.00 ± 0.47, post = 4.52 ± 0.37, p < 0.001) immediately post‐training. There was not a significant difference between skills measured immediately post‐training and in the 1‐month post‐training survey (p = 0.41). Participants reported high satisfaction with the content and methods used in this training.ConclusionsThis pilot study supports using VR SDOH training in dental education. VR technology provides new opportunities for innovative content design.
Evaluation of accuracy of laparoscopic liver mono‐segmentectomy using the Glissonian approach with indocyanine green fluorescence negative staining by comparing estimated and actual resection volumes: A single‐center retrospective cohort study
Authors: Funamizu Naotake , Ozaki Takahiro , Mishima Kohei , Igarashi Kazuharu , Omura Kenji , Takada Yasutsugu , Wakabayashi Go 
Published: February 2021

AbstractBackground/PurposeLaparoscopic liver mono‐segmentectomy (LLMS) may improve patient outcomes, but it is difficult and its accuracy and safety are unknown. We evaluated the accuracy of LLMS using Glissonian approach with indocyanine green fluorescence (ICG) negative staining.MethodsSeventy‐four patients eligible for LLMS except for segment 1 were enrolled. Preoperative three‐dimensional CT‐based surgical simulation was used to determine estimated liver resection volume (ELRV), which was compared with modified actual liver resection volume (ALRV) obtained from actual liver resection mass. The LLMS accuracy was also evaluated based on operator's experience (attending surgeon [AS] or trainee surgeon [TS]).ResultsEstimated liver resection volumes significantly correlated with ALRVs (r = .82) in all cases. Moreover, TS‐conducted LLMS also showed acceptable difference between ELRV and ALRV compared with AS‐conducted LLMS. There were no intergroup differences in estimated blood loss, operation time, time of Pringle maneuver, postoperative complications, and length of postoperative hospitalization (P < .05). Moreover, R0 resection was comparable between the AS and TS groups.ConclusionsLaparoscopic liver mono‐segmentectomy with Glissonian approach using ICG negative imaging ensured safe and accurate procedure owing to facilitated visualization of the resection line. Our approach was effective in avoiding postoperative liver dysfunction and securing radical resection. In addition, it might be helpful in TS education of LLMS.
Synthesis and biological evaluation of benzimidazolone bridged triheterocyclic compounds
Authors: Menteşe Emre , Güven Okan , Çalışkan Nedime , Baltaş Nimet 
Published: February 2021

AbstractA new series of benzimidazolone bridged triheterocyclic compounds bearing thiosemicarbazide, thiadiazole, triazole, moieties was synthesized and then screened for their in vitro urease, α‐glucosidase, and acetylcholinesterase inhibition properties for the first time. All the synthesized compounds showed an outstanding urease inhibitory effect when compared with standards. Compounds 1, 4, 5b, 5d, 6b, 6d, 7b, and 7d showed significant acetylcholinesterase inhibitory activity with IC50 values between 7.32 ± 0.58 and 12.52 ± 0.13 μg/ml comparable to donepezil (15.12 ± 0.20 μg/ml). Compound 5c, having thiosemicarbazide moiety at the positions N‐1 and N‐3 of benzimidazolone nucleus, showed the highest α‐glucosidase inhibitory activity (IC50 = 11.42 ± 0.11 μg/ml).
LI‐RADS Major Features on MRI for Diagnosing Hepatocellular Carcinoma: A Systematic Review and Meta‐Analysis
Authors: Shin Jaeseung , Lee Sunyoung , Yoon Ja Kyung , Chung Yong Eun , Choi Jin‐Young , Park Mi‐Suk 
Published: February 2021

BackgroundThe reported diagnostic performance for hepatocellular carcinoma (HCC) of each major imaging feature on MRI using standardized definitions of the Liver Imaging Reporting and Data System (LI‐RADS) is variable. It is important to know the actual performance of each LI‐RADS major imaging feature for imaging diagnosis of HCC and determine the sources of heterogeneity between the reported results.PurposeTo systematically determine the performance of each major imaging feature of LI‐RADS for diagnosing HCC using either extracellular contrast agent‐enhanced MRI (ECA‐MRI) or gadoxetate disodium‐enhanced MRI (EOB‐MRI).Study TypeSystematic review and meta‐analysis.SubjectsSixteen original articles with 3542 lesions.Field StrengthA 1.5 T and 3.0 T.AssessmentData extraction was independently performed by two reviewers who identified and reviewed original articles reporting the diagnostic performance of each LI‐RADS major imaging feature—arterial phase hyperenhancement (APHE), observation size, washout appearance, enhancing “capsule,” and threshold growth—using MRI. Study characteristics, study population characteristics, MRI characteristics, contrast agent, LI‐RADS version, reference standards, and study outcomes were extracted from included studies. Risk of bias and concerns regarding applicability were evaluated using the Quality Assessment of Diagnostic Accuracy Studies‐2 tool.Statistical TestsBivariate random‐effects models were used to obtain summary estimates of the diagnostic performance of each LI‐RADS major imaging feature. Hierarchical summary receiver operating characteristic curves were plotted. Meta‐regression analyses were performed to explore potential sources of heterogeneity.ResultsThe pooled per‐observation sensitivities and specificities for diagnosing HCC were 85% (95% confidence interval [CI] = 78%–89%) and 57% (95% CI = 44%–70%) for arterial phase hyperenhancement (APHE), 77% (95% CI = 72%–82%), and 74% (95% CI = 63%–83%) for washout appearance, and 52% (95% CI = 41%–64%) and 90% (95% CI = 85%–94%) for enhancing “capsule,” respectively.Data ConclusionsAmong the LI‐RADS major features, the sensitivity was the highest for APHE and the specificity was the highest for enhancing “capsule” in the diagnosis of HCC.Evidence Level3Technical EfficacyStage 2
Spiking dependence of SARS‐CoV‐2 pathogenicity on TMPRSS2
Authors: Abbasi Asim Z. , Kiyani Dania A. , Hamid Syeda M. , Saalim Muhammad , Fahim Ammad , Jalal Nasir 
Published: February 2021

AbstractEpidemiological data shows a discrepancy in COVID‐19 susceptibility and outcomes with some regions being more heavily affected than others. However, the factors that determine host susceptibility and pathogenicity remain elusive. An increasing number of publications highlight the role of Transmembrane Serine Protease 2 (TMPRSS2) in the susceptibility of the host cell to SARS‐CoV‐2. Cleavage of viral spike protein via the host cell's TMPRSS2 enzyme activity mediates viral entry into the host cell. The enzyme synthesis is regulated by the TMPRSS2 gene, which has also been implicated in the entry mechanisms of previously reported Coronavirus infections. In this review, we have investigated the pathogenicity of SARS‐CoV‐2 and disease susceptibility dependence on the TMPRSS2 gene as expressed in various population groups. We further discuss how the differential expression of this gene in various ethnic groups can affect the SARS‐CoV‐2 infection and Coronavirus disease (COVID)‐19 outcomes. Moreover, promising new TMPRSS2 protease blockers and inhibitors are discussed for COVID‐19 treatment.
Regional frequency analysis of annual daily rainfall maxima in Skåne, Sweden
Authors: Ul Hassan Mahmood , Noreen Zahra , Ahmed Rashid 
Published: February 2021

AbstractExtreme daily rainfall events are critical for the urban drainage system, human life, agriculture and small catchments. The information about extreme rainfall magnitudes and frequencies is immensely important for civil engineers, city planners, scientists related to water management, rescue operations and flood control works. This study illustrates the results of regional frequency analysis (RFA) of annual maximum daily rainfall (AMDR) of Skåne County, Sweden. L‐moments based heterogeneity measure (H) reveals that the Skåne County is a homogeneous region. Based on the L‐moment ratio diagram andZDiststatistic results, the generalized normal (GNO) distribution is selected as the most suitable regional distribution. The accuracy measures used in K‐fold cross validation indicate that support vector machine (SVM) model is an appropriate model to find the index rainfall at ungauged sites in the region. The sites characteristics, elevation and latitude are identified as the most important variables to explain the variation in mean annual maximum daily rainfall (MAMDR). Finally, spatial maps of predicted MAMDR for different return periods are constructed by using index rainfall combined with regional quantiles. Spatial maps offer an overall view of the expected MAMDR in the region that is helpful for multiple decision makers including infrastructure planners, city planners, emergency managers, engineers and many others.
The effects of board games on creative potential
Authors: Mercier Maxence , Lubart Todd 
Published: February 2021

AbstractThe current study aimed to investigate whether board games could be used to improve creative potential. Games have proven to be effective learning tools, and some studies have indicated positive links between creativity and other types of games, namely video games and role‐playing games. However, less is known regarding board games’ potential benefits on creativity. This exploratory study compared two types of board games: creative and non‐creative board games. We used a within‐subject repeated‐measurement design, in which participants played to both types of games, across two sessions separated by one week. We assessed creative potential with a divergent thinking task, using fluency and originality as indicators. We controlled for openness, mood states, and enjoyment. Results suggest an improvement of originality after playing both types of games, whereas no differences were observed for fluency. Considering the base level of participants, we found improvement for low‐performing participants specifically, in both fluency and originality, although analyses’ limited statistical power may have impacted the findings. These findings provide a first step in the study of creativity and board games and suggest they could help temporarily improve one’s divergent thinking capacity.
Assessing the use of mangrove pollen as a quantitative sea‐level indicator on Mahé, Seychelles
Authors: Sefton Juliet P. , Woodroffe Sarah A. 
Published: February 2021

AbstractWe investigated the potential of mangrove pollen from Mahé, Seychelles, to improve existing metre‐scale Late Holocene sediment‐based sea‐level reconstructions. Mangrove species at two mangrove sites are broadly zoned according to elevation within the tidal frame. Modern pollen rain from traps deployed for 1 year generally have a poor relationship with modern vegetation, and relatively low pollen production rates. Pollen from mangrove species that live in narrow elevation zones (e.g. Avicennia marina) are poorly represented in modern pollen rain, while pollen from mangrove species that live across a larger elevational range (e.g. Rhizophora mucronata) are relatively well represented. Pollen was found in extremely low concentrations in mangrove surface and core sediments, which inhibited further study into pollen transport and preservation. The results from this modern study demonstrate that utilizing mangrove pollen would not decrease existing metre‐scale vertical uncertainties in Late Holocene sea‐level reconstructions in the Seychelles. We suggest that this approach may still be successful in other locations if mangrove vegetation is (i) zoned at a more extensive lateral scale and (ii) is closely associated with modern pollen rain and surface sediments, and (iii) sedimentological conditions promote the preservation of pollen in fossil sequences.
Enhanced radiation gain and efficiency of a metamaterial‐inspired wideband microstrip antenna using substrate integrated waveguide technology for sub‐6 GHz wireless communication systems
Authors: Althuwayb Ayman A. 
Published: February 2021

AbstractThis paper shows a technique to enhance the radiation gain and efficiency of metamaterial (MTM) inspired planar antenna using substrate integrated waveguide (SIW) technology for sub‐6 GHz wireless communication systems. The antenna consists of MTM unit‐cells comprising series interdigital‐capacitor and short‐circuited spiral stub. The proposed antenna behaves like a leaky wave antenna. In the transmission mode the input signal propagating along the antenna structure and leaks energy. The performance of the antenna is shown to enhance by embedding a column of metallic vias between the MTM unit‐cells. This technique has no impact on the size of the antenna. The antenna was constructed on a standard FR4 dielectric substate. It had dimensions of 23.2×6.4×0.8 mm3 and had a wide operational frequency range 1.8 GHz from 3.0–4.8 GHz. After applying SIW the average gain and efficiency of the antenna were 5.8 dBi and 78%, respectively, which is an improvement of 2 dBi and 21% across 3–4.8 GHz.
A solution approach for multi‐trip vehicle routing problems with time windows, fleet sizing, and depot location
Authors: Fermín Cueto Paula , Gjeroska Ivona , Solà Vilalta Albert , Anjos Miguel F. 
Published: February 2021

AbstractWe present a solution approach for a multi‐trip vehicle routing problem with time windows in which the locations of a prescribed number of depots and the fleet sizes must also be optimized. Given the complexity of the task, we divide the problem into subproblems that are solved sequentially. First, we address strategic decisions, which are solved once and remain constant thereafter. Depots are allocated by solving a p‐median problem and fleet sizes are determined by identifying the vehicle requirements of several worst‐case demand instances. Then, we address the operational planning aspect: optimizing the vehicle routes on a daily basis to satisfy the fluctuating customer demand. We assign customers to depots based on distance and “routing effort,” and for the routing problem we combine a tailor‐made branch‐and‐cut algorithm with a heuristic consisting of a route construction phase and packing of routes into vehicle trips. Our strategic decision models are robust in the sense that when applied to unseen data, all customers could be visited with the allocated fleet sizes and depot locations. Our operational routing methods are both time and cost‐effective. The exact method yields acceptable optimality gaps in 20 min and the heuristic runs in less than 2 min, finding optimal or near‐optimal solutions for small instances. Finally, we explore the trade‐off between depot and fleet costs, and routing costs to make recommendations on the optimal number of depots. Our solution approach was entered into the 12th AIMMS‐MOPTA Optimization Modeling Competition and was awarded the first prize.
Health outcomes coding trends in the US Food and Drug Administration's Sentinel System during transition to International Classification of Diseases‐10 coding system: A brief review
Authors: Nam Young Hee , Mendelsohn Aaron B. , Panozzo Catherine A. , Maro Judith C. , Brown Jeffrey S. 
Published: February 2021

AbstractBackground and purposeThe transition from International Classification of Diseases, 9th revision, clinical modification (ICD‐9‐CM) to ICD‐10‐CM poses a challenge to epidemiologic studies that use diagnostic codes to identify health outcomes and covariates. We evaluated coding trends in health outcomes in the US Food and Drug Administration's Sentinel System during the transition.MethodsWe reviewed all health outcomes coding trends reports on the Sentinel website through November 30, 2019 and analyzed trends in incidence and prevalence across the ICD‐9‐CM and ICD‐10‐CM eras by visual inspection.ResultsWe identified 78 unique health outcomes (22 acute, 32 chronic, and 24 acute or chronic) and 140 time‐series graphs of incidence and prevalence. The reports also included code lists and code mapping methods used. Of the 140 graphs reviewed, 81 (57.9%) showed consistent trends across the ICD‐9‐CM and ICD‐10‐CM eras, while 51 (36.4%) and 8 (5.7%) graphs showed inconsistent and uncertain trends, respectively. Chronic HOIs and acute/chronic HOIs had higher proportions of consistent trends in prevalence definitions (83.9% and 78.3%, respectively) than acute HOIs (28.6%). For incidence, 55.6% of acute HOIs showed consistent trends, while 41.2% of chronic HOIs and 39.3% of acute/chronic HOIs showed consistency.ConclusionsResearchers using ICD‐10‐CM algorithms obtained by standardized mappings from ICD‐9‐CM algorithms should assess the mapping performance before use. The Sentinel reports provide a valuable resource for researchers who need to develop and assess mapping strategies. The reports could benefit from additional information about the algorithm selection process and additional details on monthly incidence and prevalence rates.Key points
We reviewed health outcomes coding trends reports on the US FDA Sentinel website through November 30, 2019 and analyzed trends in incidence and prevalence across the International Classification of Diseases, 9th revision, Clinical Modification (ICD‐9‐CM) and ICD‐10‐CM eras by code mapping method and the type of health outcomes of interest (acute, chronic, acute or chronic).
More than a third of the 140 time‐series graphs of incidence and prevalence of health outcomes showed inconsistent or uncertain trends. Consistency in trends varied by code mapping method, type of health outcomes of interest, and whether the measurement was incidence or prevalence.
Studies using ICD‐9‐CM‐based algorithms mapped to ICD‐10‐CM codes need to assess the performance of the mappings and conduct manual refinement of the algorithms as needed before using them.
Development of a training and implementation model for school‐based behavioral health interventions
Authors: Goldenthal Hayley J. , Raviv Tali , Baker Sybil , Holley Carmen , Summersett Williams Faith , Gouze Karen R. 
Published: February 2021

AbstractDespite efforts to embed mental health supports within schools, few models exist to facilitate the implementation of targeted (Tier II) evidence‐based interventions in schools. To address this gap, a collaborative partnership was formed between a pediatric teaching hospital and a large urban public school district. The current exploratory study details the development and implementation of a training model (Comprehensive Implementation Training and Support—CITAS) that addresses both consultation and organizational factors known to promote the successful implementation of Tier II interventions. Additionally, the study utilizes a case example approach to highlight initial promise and areas for future development. Results demonstrated a need for CITAS to support effective implementation and provided encouraging data on the acceptability, feasibility, and initial promise of this model. Participating clinicians demonstrated engagement and satisfaction with the activities included in the CITAS model, high levels of fidelity to the intervention, and improvement in outcomes for students participating in Anger Coping groups facilitated by CITAS clinicians. Findings also indicated that the CITAS model facilitated the navigation of organizational barriers (e.g., leadership support, resources, time) that promoted implementation success.