bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hesperetin inhibits foam cell formation and promotes cholesterol efflux in THP-1-derived macrophages by activating LXRα signal in an AMPK-dependent manner
Authors: Chen Xuanjing , Zou Dezhi , Chen Xiaoling , Wu Huanlin , Xu Danping 
Published: July 2021

AbstractCholesterol efflux from macrophages is the first step of reverse cholesterol transport (RCT), whose increase inhibits cholesterol accumulation and foam cell formation to suppress atherogenesis. Hesperetin has been reported to exert several protective effects on cardiovascular diseases, while little is known about the role of hesperetin and its underlying mechanism in macrophage foam cell formation. In this study, we sought to investigate the potential effects of hesperetin on foam cell formation and cholesterol efflux by using human macrophages, focusing on liver X receptor alpha (LXRα) and AMPK. We found that hesperetin treatment reduced foam cell formation, intracellular cholesterol levels and the cholesterol esterification rate, and increased cholesterol efflux in THP-1 macrophages. Hesperetin increased the levels of LXRα protein and its targets, including ABCA1, ABCG1, SR-BI, and phosphorylated-AMPK. Meanwhile, the hesperetin-induced increase in LXRα expression was further increased by the AMPK agonist and inhibited by an AMPK inhibitor. Meanwhile, hesperetin increased the levels of LXRα mRNA and its target genes, all of which were decreased in cells transfected with the AMPKα1/α2 small interfering RNA (siRNA). Furthermore, the hesperetin-induced inhibition of foam cell formation and promotion of cholesterol efflux were decreased by transfection of AMPKα1/α2 siRNA. In conclusions, We are the first to report that hesperetin activate AMPK in THP-1-derived macrophages. This activation upregulats LXRα and its targets, including ABCA1, ABCG1 and SR-BI, which significantly inhibits foam cell formation and promotes cholesterol efflux. Our results highlight the therapeutic potential of hesperetin to possibly reduce foam cell formation. This new mechanism might contribute the anti-atherogenic effects of hesperetin.
Optimizing anaerobic co-digestion of goat manure and cotton gin trash using biochemical methane potential (BMP) test and mathematical modeling
Authors: Kaur Harjinder , Kommalapati Raghava R. 
Published: July 2021

AbstractAnaerobic co-digestion is widely adopted to enhance process efficacy by balancing the C/N ratio of the feedstock while converting organic wastes to biomethane. Goat manure (GM) and cotton gin trash (CGT) were anaerobically co-digested in triplicate batch bioreactors. The process was optimized and evaluated utilizing mathematical equations. The liquid fraction of the digestate was analyzed for nitrate and phosphate. The co-digestions with 10 and 20% CGT having the C/N ratios of 17.7 and 19.8 yielded the highest and statistically similar 261.4 ± 4.8 and 262.6 ± 4.2 mL/gvs biomethane, respectively. The biodegradability (BD) of GM and CGT was 94.5 ± 2.7 and 37.6 ± 0.8%, respectively. The BD decreased proportionally with an increase in CGT percentage. The co-digestion having 10% CGT yielded 80–90% of biomethane in 26–39 d. The modified Gompertz model-predicted and experimental biomethane values were similar. The highest synergistic effect index of 15.6 ± 4.7% was observed in GM/CGT; 30:70 co-digestion. The concentration of nitrate and phosphate was lower in the liquid fraction of digestate than the feedstocks, indicating that these nutrients stay in the solid fraction. The results provide important insights in agro-waste management, further studies determining the effects of effluent application on plants need to be conducted.
Research and experiments on electromagnetic-driven multi-joint bionic fish
Authors: Wang Zhuo , Wang Luoyao , Wang Tao , Zhang Bo 
Published: July 2021

AbstractBased on the characteristics of high-frequency swing during fast swimming of fish, this paper designs a bionic fish-driven joint based on electromagnetic drive to achieve high-frequency swing. Aiming at the characteristic parameters of high-frequency swing control, the Fourier transform is used to separate the characteristic parameters and then compared the driving accuracy of the joints in open-loop and closed-loop. The comparison results show that the closed-loop control is performed after Fourier transform. Under the same driving conditions, the closed-loop control method can improve the joint driving accuracy. Then a bionic fish robot composed of three joints is designed according to this method and Kane method is used to model it dynamically and combined with the central pattern generator control method to complete model simulation and related experiments. The experimental results show that the bionic fish prototype can swim faster under high-frequency swing under electromagnetically driven joints.
The Significance of Tiny Contributions: Barnett and Beyond
Authors: Carlson Erik , Jedenheim Edling Magnus , Johansson Jens 
Published: July 2021

AbstractIn a discussion of Parfit's Drops of Water case, Zach Barnett has recently proposed a novel argument against “No Small Improvement”; that is, the claim that a single drop of water cannot affect the magnitude of a thirsty person's suffering. We first show that Barnett's argument can be significantly strengthened, and also that the fundamental idea behind it yields a straightforward argument for the transitivity of equal suffering (a much stronger and more important conclusion than Barnett's). We then suggest that defenders of No Small Improvement could reject a Pareto principle that is presupposed in Barnett's argument and our developments of it. However, this does not save No Small Improvement, since there is a convincing argument against this claim that does not presuppose the Pareto principle.
Second-by-second infant and mother emotion regulation and coregulation processes
Authors: Somers Jennifer A. , Luecken Linda J. , McNeish Daniel , Lemery-Chalfant Kathryn , Spinrad Tracy L. 
Published: July 2021

AbstractContext-appropriate infant physiological functioning may support emotion regulation and mother–infant emotion coregulation. Among a sample of 210 low-income Mexican-origin mothers and their 24-week-old infants, dynamic structural equation modeling (DSEM) was used to examine whether within-infant vagal functioning accounted for between-dyad differences in within-dyad second-by-second emotion regulation and coregulation during free play. Vagal functioning was captured by within-infant mean and variability (standard deviation) of respiratory sinus arrhythmia (RSA) during free play. Infant emotion regulation was quantified as emotional equilibria (within-person mean), volatility (within-person deviation from equilibrium), carryover (how quickly equilibrium is restored following a disturbance), and feedback loops (the extent to which prior affect dampens or amplifies subsequent affect) in positive and negative affect during free play; coregulation was quantified as the influence of one partner's affect on the other's subsequent affect. Among infants with lower RSA variability, positive affect fluctuated around a higher equilibrium, and negative affect fluctuated around a lower equilibrium; these infants exhibited feedback loops where their positive affect dampened their subsequent negative affect. As expected, infants with higher mean RSA exhibited more volatility in positive affect, feedback loops between their positive and negative affect, and stronger mother-driven emotion coregulation. The results highlight differences in simultaneously occurring biological and emotion regulation.
Investigation of flavonoid expression and metabolite content patterns during seed formation of Artemisia sphaerocephala Krasch.
Authors: Li Chengshuai , Zhang Lijing , Niu Decao , Nan Shuzhen , Miao Xiumei , Hu Xiaowei , Fu Hua 
Published: July 2021

AbstractFlavonoids are a group of phenolic secondary metabolites in plants that have important physiological, ecological and economic value. In this study, using the desert plant Artemisia sphaerocephala Krasch. as the sample material, the content and components of the total flavonoids in its seeds at seven different developmental stages were determined. In addition, the genes involved in flavonoid metabolism were identified by full-length transcriptome sequencing (third-generation sequencing technology based on PacBio RS II). Their expression levels were analysed by RNA-seq short reading sequencing, to reveal the patterns and regulation mechanisms of flavonoid accumulation during seed development. The key results were as follows: the content of total flavonoids in mature seeds was 15.05 mg g−1, including five subclasses: flavonols, chalcones, flavones, flavanones and proanthocyanidins, among which flavonols accounted for 45.78%. The period of rapid accumulation of flavonoids was 40–70 d following anthesis. The high expression of phenylalanine ammonia-lyase (PAL), 4-coumarate-CoA ligase (4CL) and UDP-glucose:flavonoids 3-o-glucosyltransferase (UF3GT) promoted the accumulation of total flavonoids, while the high expression of flavonoids 3′-hydroxylase (F3′H) and flavonols synthase (FLS) made flavanols the main component. Transcription factors such as the MYB-bHLH-WDR (MBW) complex and Selenium-binding protein (SBP) directly regulated the structural genes of flavonoid metabolism, while C2H2-type zinc finger (C2H2), Zinc-finger transcription factor (GATA), Dehydration-responsive element binding (DREB), Global Transcription factor Group E protein (GTE), Trihelix DNA-binding factors (Trihelix) and Phytochrome-interacting factor (PIF) indirectly promoted the synthesis of flavonoids through hormones such as brassinoidsteroids (BRs) and abscisic acid (ABA). These results provided valuable resources for the application of related genes in genetics and breeding.
RUSSELLIAN DEFINITE DESCRIPTION THEORY—A PROOF THEORETIC APPROACH
Authors: INDRZEJCZAK ANDRZEJ 
Published: July 2021

AbstractThe paper provides a proof theoretic characterization of the Russellian theory of definite descriptions (RDD) as characterized by Kalish, Montague and Mar (KMM). To this effect three sequent calculi are introduced: LKID0, LKID1 and LKID2. LKID0 is an auxiliary system which is easily shown to be equivalent to KMM. The main research is devoted to LKID1 and LKID2. The former is simpler in the sense of having smaller number of rules and, after small change, satisfies cut elimination but fails to satisfy the subformula property. In LKID2 an additional analysis of different kinds of identities leads to proliferation of rules but yields the subformula property. This refined proof theoretic analysis leading to fully analytic calculus with constructive proof of cut elimination is the main contribution of the paper.
IMPROVING STRONG NEGATION
Authors: NIKI SATORU 
Published: July 2021

AbstractStrong negation is a well-known alternative to the standard negation in intuitionistic logic. It is defined virtually by giving falsity conditions to each of the connectives. Among these, the falsity condition for implication appears to unnecessarily deviate from the standard negation. In this paper, we introduce a slight modification to strong negation, and observe its comparative advantages over the original notion. In addition, we consider the paraconsistent variants of our modification, and study their relationship with non-constructive principles and connexivity.
Safe Linkage of Cohort and Population-Based Register Data in a Genomewide Association Study on Health Care Expenditure
Authors: de Zeeuw Eveline L. , Voort Lykle , Schoonhoven Ruurd , Nivard Michel G. , Emery Thomas , Hottenga Jouke-Jan , Willemsen Gonneke A. H. M. , Dykstra Pearl A. , Zarrabi Narges , Kartopawiro John D. , Boomsma Dorret I. 
Published: July 2021

AbstractThere are research questions whose answers require record linkage of multiple databases that may be characterized by limited options for full data sharing. For this purpose, the Open Data Infrastructure for Social Science and Economic Innovations (ODISSEI) consortium has supported the development of the ODISSEI Secure Supercomputer (OSSC) platform that allows researchers to link cohort data to data from Statistics Netherlands and run large-scale analyses in a high-performance computing (HPC) environment. Here, we report a successful record linkage genomewide association (GWA) study on expenditure for total health, mental health, primary and hospital care, and medication. Record linkage for genotype data from 16,726 participants from the Netherlands Twin Register (NTR) with data from Statistics Netherlands was accomplished in the secure OSSC platform, followed by gene-based tests and estimation of total and single nucleotide polymorphism (SNP)-based heritability. The total heritability of expenditure ranged between 29.4% (SE 0.8) and 37.5% (SE 0.8), but GWA analyses did not identify SNPs or genes that were genomewide significantly associated with health care expenditure. SNP-based heritability was between 0.0% (SE 3.5) and 5.4% (SE 4.0) and was different from zero for mental health care and primary care expenditure. We conclude that successfully linking genotype data to administrative health care expenditure data from Statistics Netherlands is feasible and demonstrates a series of analyses on health care expenditure. The OSSC platform offers secure possibilities for analyzing linked data in large scale and realizing sample sizes required for GWA studies, providing invaluable opportunities to answer many new research questions.
The Generalizability of Online Experiments Conducted During the COVID-19 Pandemic
Authors: Peyton Kyle , Huber Gregory A. , Coppock Alexander 
Published: July 2021

AbstractThe COVID-19 pandemic imposed new constraints on empirical research, and online data collection by social scientists increased. Generalizing from experiments conducted during this period of persistent crisis may be challenging due to changes in how participants respond to treatments or the composition of online samples. We investigate the generalizability of COVID era survey experiments with 33 replications of 12 pre-pandemic designs, fielded across 13 quota samples of Americans between March and July 2020. We find strong evidence that pre-pandemic experiments replicate in terms of sign and significance, but at somewhat reduced magnitudes. Indirect evidence suggests an increased share of inattentive subjects on online platforms during this period, which may have contributed to smaller estimated treatment effects. Overall, we conclude that the pandemic does not pose a fundamental threat to the generalizability of online experiments to other time periods.
Constraining Plateau Uplift in Southern Africa by Combining Thermochronology, Sediment Flux, Topography, and Landscape Evolution Modeling
Authors: Stanley Jessica R. , Braun Jean , Baby Guillaume , Guillocheau François , Robin Cécile , Flowers Rebecca M. , Brown Roderick , Wildman Mark , Beucher Romain 
Published: July 2021

AbstractThe uplift of the southern African Plateau with its average elevations of ∼1,000 m is often attributed to mantle processes, but there are conflicting theories for the timing and drivers of topographic development. Evidence for most proposed plateau development histories is derived from continental erosion histories, marine stratigraphic architecture, or landscape morphology. Here we use a landscape evolution model to integrate a large data set of low‐temperature thermochronometry, sediment flux rates to surrounding marine basins, and current topography for southern Africa. We explore three main hypotheses for surface uplift: (a) southern Africa was already elevated by the Early Cretaceous before Gondwana breakup, (b) uplift and continental tilting occurred during the mid‐Cretaceous, or (c) uplift occurred during the mid to late Cenozoic. We test which of these three intervals of plateau development are plausible by using an inversion method to constrain the range in erosional and uplift model parameters that can best reproduce the observed data. Results indicate four regions of parameter space that fall into two families of uplift histories are most compatible with the data. Both uplift families have limited initial topography with some topographic uplift and continental tilting starting at ∼90–100 Ma. In one acceptable scenario, nearly all of the topography, >1,300 m, is created at this time with little Cenozoic uplift. In the other acceptable scenario, ∼400–800 m of uplift occurs in the mid‐Cretaceous with another ∼500–1,000 m of uplift in the mid‐Cenozoic. The two model scenarios have different geodynamic implications, which we compare to geodynamic models.
The January 11, 2018, Mw 6.0 Bago‐Yoma, Myanmar Earthquake: A Shallow Thrust Event Within the Deforming Bago‐Yoma Range
Authors: Fadil Wardah , Lindsey Eric O. , Wang Yu , Maung Phyo Maung , Luo Heng , Swe Tint Lwin , Tun Pa Pa , Wei Shengji 
Published: July 2021

AbstractOn January 11, 2018 (18:26 UTC), a Mw 6.0 earthquake occurred approximately 30 km west of the Sagaing Fault in the Bago‐Yoma Range (BYR). Using a local broadband seismic network and regional seismic stations, we refine the locations and moment tensors of the earthquake sequence. We relocate 98 earthquake epicenters and determine the focal mechanism and centroid depth of the mainshock and 20 aftershocks with Mw > 4. The relocated epicenters cluster in a NW‐SE direction that is consistent with the strike of the mainshock fault plane solution and the slip distribution derived from ALOS‐2 interferometric synthetic aperture radar observations. Most of the aftershocks have a pure thrust focal mechanism similar to the mainshock, except for four strike‐slip aftershocks. The refined locations and moment tensors of the thrust events clearly delineate a fault dipping ∼40° to the southwest at a depth range of 3–7 km, indicating that the earthquake sequence ruptured a previously unmapped, active fault. We interpret the earthquake sequence to be associated with pre‐existing faults within the BYR anticlinorium. This earthquake sequence and historical seismicity indicate that the upper crust of the BYR is highly stressed, resulting in ongoing distributed deformation between the oblique Rakhine megathrust and the dextral Sagaing Fault. The seismic hazard posed by these active faults has been increasing with the development of infrastructure such as dams within the BYR. Our study highlights the need for high‐resolution earthquake source parameter and strong ground motion attenuation studies for further understanding of the neotectonics of Myanmar and its related seismic hazard.
Distributed Acoustic Sensing (DAS) for Natural Microseismicity Studies: A Case Study From Antarctica
Authors: Hudson T. S. , Baird A. F. , Kendall J. M. , Kufner S. K. , Brisbourne A. M. , Smith A. M. , Butcher A. , Chalari A. , Clarke A. 
Published: July 2021

AbstractIcequakes, microseismic earthquakes at glaciers, offer insights into the dynamics of ice sheets. For the first time in the Antarctic, we explore the use of fiber optic cables as Distributed Acoustic Sensors (DAS) as a new approach for monitoring basal icequakes. We present the use of DAS for studying icequakes as a case study for the application of DAS to microseismic datasets in other geological settings. Fiber was deployed on the ice surface at Rutford Ice Stream in two different configurations. We compare the performance of DAS with a conventional geophone network for: microseismic detection and location; resolving source and noise spectra; source mechanism inversion; and measuring anisotropic shear‐wave splitting parameters. Both DAS array geometries detect fewer events than the geophone array. However, DAS is superior to geophones for recording the microseism signal, suggesting the applicability of DAS for ambient noise interferometry. We also present the first full‐waveform source mechanism inversions using DAS anywhere, successfully showing the horizontal stick‐slip nature of the icequakes. In addition, we develop an approach to use a 2D DAS array geometry as an effective multi‐component sensor capable of accurately characterizing shear‐wave splitting due to the anisotropic ice fabric. Although our observations originate from a glacial environment, the methodology and implications of this work are relevant for employing DAS in other microseismic environments.
Precambrian Crystalline Basement Properties From Pressure History Matching and Implications for Induced Seismicity in the US Midcontinent
Authors: Ansari Esmail , Bidgoli Tandis S. 
Published: July 2021

AbstractInjection‐induced seismicity across the US midcontinent has almost exclusively occurred in the crystalline basement that underlies the Arbuckle Group aquifer and its equivalents, the primary wastewater disposal zone in this region. However, the properties of the basement are not well known. Newly compiled data, from Class I wells in Kansas, provide a unique record of pressures in the Arbuckle and an opportunity to constrain the reservoir‐scale properties of the basement such as permeability, diffusivity, and specific storage. Constraints on these parameters are critical for modeling fluid flow and pressures across the entire Arbuckle‐basement system, and are necessary for accurate evaluation and prediction of injection‐induced earthquakes. Here, we present a detailed, three‐dimensional geological and pressure history‐matched numerical model for the Arbuckle and basement, based on data from >400 wells covering a large region in south‐central Kansas, where injection‐induced seismicity has been concentrated since 2014. Simulations of dynamic data from 319 wells indicate that Arbuckle pressures have increased by 1.1 MPa in high injection rate areas and an overpressure of <0.1 MPa may be the cause of seismicity in the basement. Pressure‐history matching also yields the likely range in porosity (0.3%–7%), permeability (0.1–0.7 mD), and diffusivity (0.004–0.07 m2/s) for the basement. The resulting estimates suggest reservoir‐scale properties of the basement are enhanced by faults and fractures. Importantly, the diffusivities determined in this study are lower than estimates derived from Kansas earthquake triggering fronts, and suggest that such seismicity‐based techniques may have limitations, particularly where space‐time patterns between injection and seismicity are complex.
Estimation of Absolute Stress in the Hypocentral Region of the 2019 Ridgecrest, California, Earthquakes
Authors: Fialko Y. 
Published: July 2021

AbstractStrength of the upper brittle part of the Earth's lithosphere controls deformation styles in tectonically active regions, surface topography, seismicity, and the occurrence of plate tectonics, yet it remains one of the most debated quantities in geophysics. Direct measurements of stresses acting at seismogenic depths are largely lacking. Seismic data (in particular, earthquake focal mechanisms) have been used to infer orientation of the principal stress axes. I show that the focal mechanism data can be combined with information from precise earthquake locations to place constraints not only on the orientation, but also on the magnitude of absolute stress at depth. The proposed method uses relative attitudes of conjugate faults to evaluate the amplitude and spatial heterogeneity of the deviatoric stress and frictional strength in the seismogenic zone. Relative fault orientations (dihedral angles) and sense of slip are determined using quasi‐planar clusters of seismicity and their composite focal mechanisms. The observed distribution of dihedral angles between active conjugate faults in the area of Ridgecrest (California, USA) that hosted a recent sequence of strong earthquakes suggests in situ coefficient of friction of 0.4–0.6, and depth‐averaged shear stress on the order of 25–40 MPa, intermediate between predictions of the “strong” and “weak” fault theories.