bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of technological innovation capabilities on companies' innovation and marketing performance: A field study on Technopark companies in Turkey
Authors: BİL Erkan , ÖZDEMİR Erkan 
Published: August 2021

Purpose - The purpose of this study is to evaluate the effects of the technological innovation capabilities of companies carrying out R&D and innovation activities on product performance and marketing performance.
Methodology - The main population of this study comprises a total of 4916 companies that carry out their activities within the body of 56 Technoparks in Turkey on April 2018. IBM SPSS 23 and IBM AMOS 23 package programs were used in the analysis. In the study, explanatory factor analysis, confirmatory factor analysis, and Structural Equation Modeling (SEM) analysis were performed to test the relationships in the proposed research model, respectively.
Findings - As a result of the Structural Equation Modeling analysis, it was found that R&D capability has significant and positive effects on product performance and marketing performance over product performance; and the learning capability, marketing capability, and finally product performance directly on marketing performance.
Originality/value - The main contribution of this study to the literature is that it not only explains the effects of some types of innovation on business performance but also deals with the relationship between innovation capabilities and business performance of companies in a more specific approach and reveals the effects of technological innovation capabilities on both product and marketing performance.
Effect Of α- Tocopherol and Ascorbic Acid on the Genotoxicity by Gamma-Irradiation in Drosophila melanogaster
Authors: EMECEN Güzin , ÜNLÜ Hacer 
Published: August 2021

Toksik olmayan ve etkili doğal antioksidanların radyoprotektif etkilerinin belirlenmesi önemli bir konudur. E Vitamini, radyasyon ile oluşan serbest radikalleri etkili bir şekilde temizlemesiyle bilinmektedir. Bununla birlikte, C vitamini konsantrasyona bağlı olarak prooksidan veya antioksidan görevi görebilir.
Bu çalışmada, Drosophila melanogaster’de gama ışınlamasına karşı E ve C vitamini uygulamasının (ayrı ayrı ve birlikte) antimutajenik etkilerini araştırdık. Bu amaçla, SLRL ve Translokasyon genetik toksikoloji testlerini kullandık. Her iki test sisteminde, sadece erkek bireylere radyasyon ve vitamin uygulamaları yapıldı. Bu erkekler, daha önce vitamin ve radyasyon almamış dişilerle çaprazlandı ve radyasyon yoluyla üretilen letal kromozomları taşıyan bireyleri belirlemek için bu erkeklerin yavruları tarandı. Ardından, vitamin uygulamasının, radyasyonla oluşmuş letal kromozom taşıyan birey sayısını azaltıp azaltmadığını araştırdık. Sonuçlar, E vitamininin letal frekansını yalnızca tek başına ve ışınlamadan önce uygulandığında önemli ölçüde azalttığını göstermiştir. C vitamini hiçbir şekilde önleyici etki göstermemiştir. C ve E vitaminlerinin birlikte verilmesinin, kontrole kıyasla letaliteyi azaltmadığı tespit edilmiştir.
АВТОМАТИЗАЦІЯ ПРОЦЕСУ ДИСТИЛЯЦІЇ МІСЦЕЛИ
Authors: Дишлєвой О. О. , Світий І. М. , Воінова С. О. 
Published: August 2021

Соняшникова олія для України – продукт стратегічний. Вона є важливим джерелом валютних надходжень до країни та цінним харчовим продуктом для її громадян. Зростаюча конкуренція на світових ринках, зокрема на ринку соняшникової олії, вимагає впровадження технологій, що забезпечують підвищення якості та зниження собівартості готової продукції. А це вимагає підвищення вимог до точності керування процесами.
У даній роботі для досягнення мети підвищення ефективності виробництва рафінованої соняшникової олії було означено задачу підвищення ефективності системи автоматичного регулювання (САР) параметрів процесу дистиляції місцели.
Аналіз літературних джерел з розробки САР для процесу дистиляції місцели виявив значний резерв підвищення ефективності керування процесом.
Для вирішення задачі побудови ефективної САР процес дистиляції місцели в трубчастому дистиляторі було проаналізовано як об’єкт керування (ОК), було отримано його концептуальну модель, проідентифіковано математичну модель, яку відтворено в середовищі імітаційного моделювання у вигляді імітаційної моделі.
На першому етапі синтезу САР реалізовано, як двоканальну САР температури та рівню місцели. Надалі здійснювалося підвищувалася динамічна точність САР шляхом забезпечення автономності контуру регулювання рівню. Наступним етапом було досліджено вплив варіації параметрів ОК на якість керування. Запропоновано алгоритми керування на основі нечіткого та нейронного регулятора. Подальші дослідження пов’язані з розширенням моделі ОК за рахунок введення моделі концентрації гексану, що є безпосереднім показником якості олії. Запропоновано каскадний контур регулювання концентрації гексану з проміжною точкою: температурою дистиляції місцели. Подальші дослідження пов’язані з доповненням каскадної САР контуром гарантування, що забезпечує підвищення ефективності САР в умовах дії інтенсивних координатних та параметричних збурень.
На всіх етапах синтезу варіанти САР було проаналізовано на відповідність гранично припустимим вимогам та на «грубість» або чутливість до варіації параметрів об’єкту керування.
В роботі також опрацьовано питання програмної реалізації розроблених алгоритмів регулювання в середовищі TIA Portal та програмної взаємодії з оператором установки шляхом розробки графічного інтерфейсу взаємодії на основі SCADA.
У майбутньому запропоновані рішення складуть основу модернізованої ефективної системи керування процесом дистиляції місцели, яка є інтелектуальним ядром автоматизованого робочого місця оператора.
Dialysis and Total Health Care Costs in the United States and Worldwide: The Financial Impact of a Single-Payer Dominant System in the US
Authors: Pockros Benjamin M. , Finch Daniel J. , Weiner Daniel E. 
Published: August 2021

Significance Statement
In the United States, dialysis provision is an example of a robust, single-payer dominant system with cost containment. When compared with the cost of dialysis in other countries, Medicare dialysis costs in the United States as a function of overall health care expenditures are approximately $60,000 per patient less than expected, likely due to substantial cost containment imposed by Medicare as the dominant payer.
The Emancipation and Liberation of One Karen Smith
Authors: Wilson Destinee , Lang Alexandra , Campos Chloe 
Published: August 2021

Set in the late 1910s, a white woman named Karen Smith lives an ordinary life married to her husband in Brooklyn, New York in a lovely home. Brad, the husband of Karen, has a job on Wall Street, where he commutes to work. He is very controlling, misogynist, and racist. They have been married for five years and have a normal and happy life, the complete American Dream. During this time, the women of the United States are embroiled in the fight for suffrage, with many in opposition. Karen and Brad are a part of the anti-suffrage movement that believes in a limited role for women, such as “working in the home.” Realizing that the suffrage movement was gaining momentum, Karen decides to infiltrate the National Women’s Party. Karen is determined to find out insider information to harm the suffrage movement. While engaging in espionage, Karen discovers herself, makes friends, and decides how she wants to be remembered by history.
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HOW INTERNATIONAL STUDENTS IN CHINESE MEDICAL SCHOOLS PERCEIVE DISTANT LEARNING DURING THE COVID-19 PANDEMIC
Authors: AlGerafi Mohammed , Zhang Wenlan 
Published: August 2021

Purpose: The aim of this study is to assess the perception of international medical students of e-learning in China, since medical teaching during the COVID-19 pandemic had to adapt to challenges, and students had to cope with the new teaching modality, more so international students. Therefore, the opinion of students with their first contact to a fully virtual education will be helpful to modify e-teaching to better suit the students’ needs. Method: Four hundred seven medical students, in China, were recruited via social media and were asked to complete structured questionnaires, regarding technical and content aspects of their e-courses. Findings: Most issues reported were of technical nature, especially for students attending the school distantly and network instability/unavailability was frequently (52.48%). Moreover, the audio was less helpful than texts/images and the senior students were less satisfied with the technical (0.005) and content (p=0.001) aspects. They also were more critical of their teachers’ performance (p=0.042). Clinical cases and scenarios also received the lowest score. Implications for research and practice: Overall students did not feel confident with the e-learning, comfortable implementing it to patients and were reluctant to embrace it. Both technical difficulties and understanding issues impeded international students from embracing e-learning medical teaching, in China and efforts need to be made to acclimatise them to this new reality.
Pemberdayaan Perempuan Melalui Implementasi Program Kerajinan Bordir di Desa Karang Malang, Gebog Kabupaten Kudus
Authors: Isti Sutoyo Ria 
Published: August 2021

<p class="06IsiAbstrak">Bordir menjadi bagian yang di minati masyarakat sebagai bagian dari pemberdayaan masyarakat dewasa ini, khususnya dalam lingkup pemberdayaan perempuan. Sehingga, berbagai sektor ekonomi UMKM masyarakat sebagian besar menggunakan kerajinan ini sebagai media pendongkrak ekonomi masyarakat. meskipun menjanjikan prospek yang cukup mumpuni guna meningkatkan sector ekonomi masyarakat, akan tetapi implementasi kerajinan ini sebagai bagian dari penggerak ekonomi masyarakat cenderung masih belum sepenuhnya mampu memberdayakan masyarakat. maka, tujuan dari penelitian ini yakni mengetahui deskripsi yang lebih eksploratif tentang implementasi dari kerajinan border untuk pemberdayaan perempuan, khususnya di desa Karang Malang Kudus. Untuk mengetahui gambaran tersebut, maka penelitian ini menggunakan metode penelitian kualitatif deskriptif dengan menggunakan wawancara semi terstruktur, observasi non partisipasi aktif sebagai alat pengumpulan data. Sehingga, didapatkan hasil bahwa melalui implementasi program kerajinan bdordir yang dilakukan di desa karangmalang ini, mampu memberikan peningkatan dalam sector pengembangan ekonomi keuarga, meskipun belum maksimal dalam pengembangannya, khususnya terkait dengan pemberdayaan perempuan. Akan tetapi dalam kegiatannya, program yang dilakukan bisa memberikan dampak yang nyata sebagai bagian dari pemberdayaan perempuan, khususnya ibu rumah tangga.</p>
Prognostic Efficacy of the RTN1 Gene in Patients with Diffuse Large B-Cell Lymphoma
Authors: Zamani-Ahmadmahmudi Mohamad , Nassiri Seyed Mahdi , Asadabadi Amir 
Published: August 2021

Abstract
Gene expression profiling has been vastly used to extract the genes that can predict the clinical outcome in patients with diverse cancers, including diffuse large B-cell lymphoma (DLBCL). With the aid of bioinformatics and computational analysis on gene expression data, various prognostic gene signatures for DLBCL have been recently developed. The major drawback of the previous signatures is their inability to correctly predict survival in external data sets. In other words, they are not reproducible in other datasets. Hence, in this study, we sought to determine the gene(s) that can reproducibly and robustly predict survival in patients with DLBCL. Gene expression data were extracted from 7 datasets containing 1636 patients (GSE10846 [n=420], GSE31312 [n=470], GSE11318 [n=203], GSE32918 [n=172], GSE4475 [n=123], GSE69051 [n=157], and GSE34171 [n=91]). Genes significantly associated with overall survival were detected using the univariate Cox proportional hazards analysis with a P value <0.001 and a false discovery rate (FDR) <5%. Thereafter, significant genes common between all the datasets were extracted. Additionally, chromosomal aberrations in the corresponding region of the final common gene(s) were evaluated as copy number alterations using the single nucleotide polymorphism (SNP) data of 570 patients with DLBCL (GSE58718 [n=242], GSE57277 [n=148], and GSE34171 [n=180]). Our results indicated that reticulon family gene 1 (RTN1) was the only gene that met our rigorous pipeline criteria and associated with a favorable clinical outcome in all the datasets (P<0.001, FDR<5%). In the multivariate Cox proportional hazards analysis, this gene remained independent of the routine international prognostic index components (i.e., age, stage, lactate dehydrogenase level, Eastern Cooperative Oncology Group [ECOG] performance status, and number of extranodal sites) (P<0.0001). Furthermore, no significant chromosomal aberration was found in the RTN1 genomic region (14q23.1: Start 59,595,976/ End 59,870,966).
Depression is associated with discoordination between heart rate variability and physical acceleration in older women
Authors: Taniguchi Kentaro , Shimouchi Akito , Jinno Naoya , Seiyama Akitoshi 
Published: August 2021

Abstract
Depression associates closely with autonomic nervous system and physical activity, however, there have been no studies on the relationship between depression and the coordination of heart rate variability (HRV) and physical acceleration (PA). Ninety-five adult women were divided into non-older and older groups. The non-older group comprised 50 adulte women (below 60 years), and the older group comprised 45 women (above 60 years). HRV and PA data were simultaneously obtained every minute for 24 h during the free-moving day by using the ActiveTracer accelerometer. The ratios of low frequency/high frequency and high frequency were used as HRV indices, indicating sympathetic and parasympathetic nervous activities, respectively. Lag time was determined as the time difference indicated by the maximum absolute cross-correlation coefficients obtained from the analysis between the HRV components and the PA. We defined %Lag0 as the % frequency of the lag = 0 min between HRV and PA in 1 h. The General Health Questionnaire 28 (GHQ28) was used to evaluate the effects of psychological distress, including depression. In the hour before the night’s sleep, %Lag0 was significantly lower in older women with depression (GHQ28 subscale D) than in older women without depression (p <0.05). However, no significant difference between %Lag0 and depression status was observed in the hour after waking in older women. The results suggest that impairments in coordination between HRV and PA are associated with depression in older women, particularly in the hour before a night’s sleep on free-moving days.
Investigation of Disease Spectrum and Analysis of Risk Factor for Digestive System Diseases of Chinese Army During a Field Training on The Midland of China
Authors: Zhang Guanjun , Li Mingyang , Lin Fan , Zhang Yizhe , Li Haohui , Song Hongwen , Li Bin 
Published: August 2021

Abstract
Objective To investigate the digestive disease spectrum of Chinese army servicemen during a field training on the midland and to analyze risk factors of diseases in order to discuss the relative prevention and treatment strategies.Methods Seven troops during a field training on the midland of China were randomly selected by using stratified cluster random sampling methods, all soldiers in that received a questionnaire survey, and then we collected all questionnaires and summarized the soldiers’ digestive system disease spectrum, and discussed risk factors for diseases.Results 3055 valid questionnaires were finally collected,896 soldiers had digestive symptoms, and of all symptoms diarrhea was the most common,whose ratio was 29.3%; 507 soldiers suffered from digestive system diseases, including gastritis, enteritis,digestive ulcer, functional bowel disease, which were more common. By the logistic regression analysis, length of military service time, identity of army officer,length of a field training time,training pressure, chilled abdomen, and defiled food were possible risk factors for digestive diseases.Conclusions During a field training, a healthy and regular diet, the thermal outfit, appropriate decompression of negative emotions and reasonable training time may effectively decrease the risk of digestive diseases, so that to reduce attrition.
The Effect of Upfront Intensive Therapy on Primary Resistance in Metastatic Castration-sensitive Prostate Cancer: A Multicenter Retrospective Study
Authors: Tanaka Toshikazu , Hatakeyama Shingo , Noro Daisuke , Kodama Hirotake , Konishi Sakae , Okita Kazutaka , Hosogoe Shogo , Ozaki Kai , Narita Takuma , Tokui Noriko , Okamoto Teppei , Yamamoto Hayato , Imai Atsushi , Yoneyama Takahiro , Hashimoto Yasuhiro , Ohyama Chikara 
Published: August 2021

Abstract
We investigated the effect of upfront intensive therapy on primary resistance in patients with metastatic castration-sensitive prostate cancer (mCSPC) in real-world practice. We retrospectively evaluated the medical records of 348 patients with newly diagnosed mCSPC who had a high tumor-burden between January 2008 and May 2021. We compared the oncological outcomes between patients who received conventional androgen deprivation therapy ± bicalutamide (ADT group) and those treated with upfront intensive therapies (upfront group). The primary purpose was comparing the rate of primary resistance between the ADT and upfront groups. The primary resistance was defined as a castration-resistant prostate cancer (CRPC) progression < 6 or < 12 months. The secondary purposes were comparing the CRPC-free survival and overall survival (OS) between the ADT and upfront groups, and assessing safety in the upfront group. We identified 206 and 142 patients for the ADT and upfront groups, respectively. We found the rate of CRPC progression < 6 and < 12 months was significantly lower in the upfront group (9.2% and 18%, respectively) than that in the ADT group (21% and 51%, respectively). The upfront therapy was significantly associated with favorable CRPC-free survival and OS than that in the ADT group in propensity-score adjusted models. A higher rate of any grade adverse events was observed in the upfront docetaxel (94%) than that of the upfront abiraterone (34%) or apalutamide/enzalutamide (39%). In conclusion, the upfront intensive therapy significantly improved the rate of primary resistance and oncological outcomes in patients with mCSPC in real-world practice.
Thermodynamic Analysis of Methanol Synthesis via CO2 Hydrogenation Reaction
Authors: Kanuri Suresh , Singh Satyapaul A. , Datta Santanu P. , Chakraborty Chanchal , Roy Sounak , Dinda Srikanta 
Published: August 2021

Abstract
The most inspiring opportunity to reduce greenhouse gas emissions is direct hydrogenation of CO2 into a commodity of products, which is also an appealing choice for generating renewable energy. CO2 hydrogenation can yield methanol which has a broad range of applications. In the present study, a thermodynamic feasibility analysis of the CO2 hydrogenation reaction is carried out using the Aspen Plus tool. CO2 hydrogenation to methanol, reverse-water-gas-shift (RWGS), and methanol decomposition reactions were considered in this analysis. The effect of different parameters such as temperature (ranging from 50 to 500°C), pressures (ranging from 1 bar to 50 bar), and CO2:H2 molar ratio (ranging from 1:3 to 1:20) on methanol yield has been investigated. The Aspen predicted data is compared with the fixed-bed reactor experimental data. High pressure and low-temperature conditions are found to be the favourable option for a higher value of methanol yield. The CO2 conversion and CH3OH selectivity are favourable when the H2/CO2 molar ratio is greater than 3. A substantial gap between the Aspen predicted equilibrium conversion of CO2 and the experimental value of CO2 conversion is observed in the study.
Federated Disentangled Representation Learning for Unsupervised Brain Anomaly Detection
Authors: Bercea Cosmin , Wiestler Benedikt , Rueckert Daniel , Albarqouni Shadi 
Published: August 2021

Abstract
Recent advances in Deep Learning (DL) and the increased use of brain MRI have provided a great opportunity and interest in automated anomaly segmentation to support human interpretation and improve clinical workflow. However, medical imaging must be curated by trained clinicians, which is time-consuming and expensive. Further, data is often scattered across multiple institutions, with privacy regulations limiting its access. Here, we present FedDis (Federated Disentangled representation learning for unsupervised brain pathology segmentation) to collaboratively train an unsupervised deep convolutional neural network on 1532 healthy MR scans from four different institutions, and evaluate its performance in identifying abnormal brain MRIs including multiple sclerosis (MS) lesions, low-grade tumors (LGG), and high-grade tumors/glioblastoma (HGG/GB) on a total of ~500 scans from 5 different institutions and datasets. FedDis mitigates the statistical heterogeneity given by different scanners by disentangling the parameter space into global, i.e., shape and local, i.e., appearance. We only share the former with the federated clients to leverage common anatomical structure while keeping client-specific contrast information private.
We have shown that our collaborative approach, FedDis, improves anomaly segmentation results by 99.74% for MS and 40.45% for tumors over locally trained models without the need for annotations or sharing private local data. We found out that FedDis is especially beneficial for clients that share both healthy and anomaly data coming from the same institute, improving their local anomaly detection performance by up to 227% for MS lesions and 77% for brain tumors.
Two-pronged anti-tumor therapy by a new polymer-paclitaxel conjugate micelle with an anti-multidrug resistance effect
Authors: Du Juan , Zong Lanlan , Li Mengmeng , Qiao Yonghui , Yu Keke , Pu Xiaohui 
Published: August 2021

Abstract
Cancerous tumors are still a major disease that threatens human life, with tumor multidrug resistance (MDR) being one of the main reasons for the failure of chemotherapy. Here, a reduction-sensitive polymer prodrug micelle, mPEG-DCA-SS-PTX (PDSP), was manufactured with a new polymer inhibitor of drug-resistance as a carrier to overcome MDR and improve the anti-tumor effect of paclitaxel (PTX). The PDSP micelles display good stability, double-responsive drug release, and excellent biocompatibility. The PDSP micelles reduced the cytotoxicity of PTX to normal HL-7702 cells, and enhanced that to SMMC-7721 and MCF-7 cells in vitro. Improved sensitivity of A549/ADR to PDSP was also observed in vitro. Furthermore, in vivo experiments show reduced systemic toxicity and enhanced therapeutic efficacy of DOX to H22 subcutaneous tumor-bearing mice. This work proves the reduction sensitive polymer prodrug micelles carried by the new polymer inhibitor can be used as an alternative delivery system to target tumors and reverse MDR for paclitaxel and other tumor-resistant drugs.