bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Outsourced Decryption ABE Model using ECC in Internet of Things
Authors: Kumar Dilip , Kumar Manoj , Gupta Gaurav 
Published: November 2021

Internet of Things (IoT) is a modern technology that is applicable almost everywhere nowadays. Everything is connected to the Internet in the modern digital era. IoT is a collection of things that are interconnected to share information. Devices connected to IoT networks have some limitations in performing heavy computational tasks because of the availability of less computational and battery power. Attribute Based Encryption (ABE) is a modern public-key cryptographic technique that provides privacy with access control. The bilinear map is an expensive operation that is used in most of the ABE schemes. Elliptic Curve Cryptography (ECC) is an alternative for bilinear pairing to reduce the computation of encryption and decryption in ABE schemes. The process of encryption and decryption of ABE is a heavy computational task for resource-constrained devices. In this paper, an outsourcing-based decryption of ABE using ECC is proposed to reduce the decryption overhead of devices that have limited computational resources. Our scheme divides the computation of the decryption of ABE into two stages: first, the partial decryption of ciphertext in the cloud server, and second, the final decryption of partially decrypted ciphertext by the data user to retrieve the original message. This scheme is secure against the malicious cloud server by adding a blinding factor into the secret to be shared. The blinding factor is shared with intended users through attribute authority. The experimental results demonstrate that our scheme can reduce the decryption complexity and save the computational time of devices, compared to the existing schemes. Thus the proposed scheme is applicable for lightweight devices used in IoT.
VSD-MOEA: A Dominance-Based Multiobjective Evolutionary Algorithm with Explicit Variable Space Diversity Management
Authors: Castillo Joel Chacón , Segura Carlos , Coello Carlos A. Coello 
Published: November 2021

Abstract
Most state-of-the-art Multiobjective Evolutionary Algorithms (moeas) promote the preservation of diversity of objective function space but neglect the diversity of decision variable space. The aim of this article is to show that explicitly managing the amount of diversity maintained in the decision variable space is useful to increase the quality of moeas when taking into account metrics of the objective space. Our novel Variable Space Diversity-based MOEA (vsd-moea) explicitly considers the diversity of both decision variable and objective function space. This information is used with the aim of properly adapting the balance between exploration and intensification during the optimization process. Particularly, at the initial stages, decisions made by the approach are more biased by the information on the diversity of the variable space, whereas it gradually grants more importance to the diversity of objective function space as the evolution progresses. The latter is achieved through a novel density estimator. The new method is compared with state-of-art moeas using several benchmarks with two and three objectives. This novel proposal yields much better results than state-of-the-art schemes when considering metrics applied on objective function space, exhibiting a more stable and robust behavior.
A Statistical Analysis of Summarization Evaluation Metrics Using Resampling Methods
Authors: Deutsch Daniel , Dror Rotem , Roth Dan 
Published: November 2021

Abstract
The quality of a summarization evaluation metric is quantified by calculating the correlation between its scores and human annotations across a large number of summaries. Currently, it is unclear how precise these correlation estimates are, nor whether differences between two metrics’ correlations reflect a true difference or if it is due to mere chance. In this work, we address these two problems by proposing methods for calculating confidence intervals and running hypothesis tests for correlations using two resampling methods, bootstrapping and permutation. After evaluating which of the proposed methods is most appropriate for summarization through two simulation experiments, we analyze the results of applying these methods to several different automatic evaluation metrics across three sets of human annotations. We find that the confidence intervals are rather wide, demonstrating high uncertainty in the reliability of automatic metrics. Further, although many metrics fail to show statistical improvements over ROUGE, two recent works, QAEval and BERTScore, do so in some evaluation settings.1
Muslim Modernism in Turkish: Assessing the Thought of Late Ottoman Intellectual Mehmed Akif
Authors: Hammond Andrew 
Published: November 2021

Abstract
Late Ottoman intellectual Mehmed Akif (1873–1936) was for decades depicted in Turkish public discourse in generic terms as an Islamist radical opposed to the secular nation state. Through Akif’s poetry, articles, translations, correspondence from his exile in Egypt, and biographical detail revealed in the scattered memoirs of students and colleagues, this article offers a reappraisal of his thought as a leading Muslim modernist who adapted the thinking of Egyptian religious scholar Muḥammad ʿAbduh (1849–1905) to an Ottoman and then Turkish audience in the formulation of an early, prescient compromise between religion and nationalism. The article also notes remarkable similarities between Akif and Indian thinker Muḥammad Iqbāl (1877–1938), whom Akif was instrumental in introducing to Arab audiences, and suggests that, once political Islam had later gained currency across all fields of public life, Akif became an alternative to nationalist icon Ziya Gökalp (1876–1924) as an intellectual symbol of the republic.
Can Aquatic Invertebrates within Public Aquaria Fit the Five Domain Welfare Model?
Authors: Perkins Kerry 
Published: November 2021

Abstract
Welfare within zoos and aquariums has come under increasing scrutiny due to the change in public opinion of animals in captivity. It is vital that as an industry mechanisms and frameworks are in place to determine welfare of animals within our care. Due to potential bias in current welfare models toward terrestrial vertebrates, it is important to determine whether they can be utilised in differing environments such as aquariums. Using the most recent five domain model (Mellor, 2017) the possible application within public aquaria is discussed, considering each domain in respect to aquatic invertebrates, an often-neglected group of organisms when considering welfare in aquaria. This review highlights the additional considerations needed when applying the five domain model to this diverse group of organisms. Furthermore, the identification of gaps within the current literature is discussed in respect to whether the full five domain model can be currently be applied at this time.
The Effects of Heavy Precipitation on Polarimetric Radio Occultation (PRO) Bending Angle Observations
Authors: Wang Kuo-Nung , Ao Chi O. , Padullés Ramon , Turk Francis J. , Juárez Manuel de la Torre , Cardellach Estel 
Published: November 2021

Abstract
Following the successful launch of the Spanish PAZ mission the proof of concept experiment “Radio Occultation and Heavy Precipitation with PAZ” (ROHP-PAZ) started operating in May 2018. The ROHP-PAZ observations demonstrated that precise measurements of the phase shift between horizontal and vertical polarizations from Global Navigation Satellite System (GNSS) L-band signals are sensitive to oriented hydrometeors along the ray paths. While this differential phase shift measurement as a function of time has proven very useful, the regular radio occultation (RO) intermediate products from different polarized channels, such as bending angle and phase retrievals on the domain of impact parameter, have never been exploited. In this research, we studied the characteristics of polarimetric phase and bending angle difference retrieved by the radio-holographic (RH) method to mitigate atmospheric multipath effect and to explore their use in data assimilation. To validate RH approach in polarimetric retrievals, we performed end-to-end simulations where the hydrometeors are modeled by the effective refractivity with different horizontal extents. The simulation results demonstrate that the strong precipitation (>15 mm h−1) with 40-km horizontal extent can be detected with the retrieved bending angle shift. The calibration process on the impact parameter domain has also been developed to extract the differential phase and bending angle shift from the actual polarimetric RO data. Statistics from the PAZ data shows that the mean retrieved RH polarimetric phase shift with various horizontal extent is approximately proportional to the tangent point location rain rate at a ratio of 0.02 rad (mm h−1)−1.
Shared Determinants for Human Papillomavirus and COVID-19 Vaccination Intention: An Opportunity for Resource Consolidation
Authors: Olagoke Ayokunle A. , Carnahan Leslie R. , Olagoke Olakanmi , Molina Yamilé 
Published: November 2021

Purpose This study aimed at targeting shared factors that influence the prevention of multiple diseases, which can help address various health problems simultaneously. We identified correlates of human papillomavirus (HPV) vaccination that overlap with COVID-19 vaccination. Design Cross-sectional survey data. Setting Online Qualtrics recruitment panel. Subject Religious parents of 342 adolescents who were unvaccinated for HPV (response rate was 68.1%). Measures Outcome variables were COVID-19 vaccination intention for (1) self, (2) child, and (3) HPV vaccination intention for child. Independent variables were psychological factors. Covariates were sociodemographic and socioeconomic factors. Analysis We conducted multivariate linear regressions on each outcome variable after controlling for covariates. Result Some psychological correlates of HPV overlapped as protective factors for all three outcomes. Higher perceived vulnerability of child to HPV was associated with higher vaccination intention against COVID-19 for self (β = .37, 95% confidence interval [CI] = .25–.48), child (β = .32, .21–.44), and HPV for child (β = .38, .27–.49). Higher perceived response efficacy of HPV vaccine was associated with greater vaccination intention against COVID-19 for self (β = .46, .33–.59), child (β = .41, .28–.53), and HPV for child (β = .75, .64–.85). Conclusion Given the overlap in HPV and COVID-19 vaccination correlates, interventions should target shared factors that address both diseases to maximize public health efforts. A major limitation of this study is the inability to measure the actual vaccination behavior.
Factors detrimental to work productivity and daily activities in systemic lupus erythematosus patients – Analysis of the German LuLa study
Authors: Kernder Anna , Düsing Christina , Richter Jutta , Brinks Ralph , Fischer-Betz Rebecca , Winkler-Rohlfing Borgi , Aringer Martin , Schneider Matthias , Chehab Gamal 
Published: November 2021

Objective The aim of this study was to identify factors associated with impaired work productivity and impaired daily activities in patients with systemic lupus erythematosus (SLE). Methods The LuLa study is a longitudinal patient-reported study. Beyond sociodemographic data, work productivity, daily activities and fatigue, several other clinical outcome parameters (e.g. mental health–related quality of life and physical functioning, disease activity, damage and pain) were surveyed with validated questionnaires. The effects of confounders on work productivity (WPAI 2) and daily activity domains (WPAI 4) were studied by multivariate regression analysis. Results A total of 585 patients completed the questionnaire of whom 259 were employed and analysed. The median impairment in work productivity (WPAI 2) was 20% (Q1–3 0–40), and the median impairment in daily activities (WPAI 4) was 30% (Q1–3 10–50%). Multivariate regression analysis revealed that fatigue, pain, disease activity and health-related quality of life affected WPAI 2 and 4. Furthermore, we observed distinct synergistic effects of fatigue, disease activity and pain on both work productivity and daily activities: a higher impact of fatigue was associated with the reported extent of pain or disease activity. Conclusion In employed patients with SLE, impaired work productivity and impaired daily activities were frequently reported. Fatigue, pain, disease activity and health-related quality of life demonstrated a detrimental impact, with a synergistic effect of fatigue, disease activity and pain. Hence, both optimized pain management and targeted immunomodulatory therapy are important for preserving active participation in life among patients with fatigue.
A Modified Extra-articular Lateral Column Lengthening Procedure for Adult Acquired Flatfoot Deformity
Authors: Shih Yin-Chuan , Farn Chui Jia , Wang Chen-Chie , Wang Chung-Li , Chen Pei-Yu 
Published: November 2021

Background: Lateral column lengthening (LCL), originally described by Evans, is an established procedure to correct stage II adult acquired flatfoot deformity (AAFD). However, the relative position between the facets is violated, and other problems may include nonunion, malunion, and calcaneocuboid (CC) joint subluxation. Herein, we report a modified extra-articular technique of LCL with hockey-stick osteotomy, which preserves the subtalar joint as a whole, increases bony apposition to enhance healing ability, and preserves the insertion of the calcaneofibular ligament to stabilize the posterior fragment to promote adduction of the forefoot. Methods: We retrospectively recruited 24 patients (26 feet) with stage II AAFD who underwent extra-articular LCL. The mean age was 55.7 ± 15.7 years, and the mean follow-up period was 33.4 ± 12.1 months. Associated procedures of spring ligament repair/reconstruction and posterior tibial tendon plication or flexor digitorum longus transfer were routinely performed and may also include a Cotton osteotomy, heel cord lengthening, or hallux valgus correction. Clinical and radiographic outcomes at the final follow-up were compared with the preoperative assessments. Results: All patients achieved calcaneus union within 3 months of operation. The VAS pain score improved from 5.3 ± 0.75 preoperatively to 1.2 ± 0.79 at the final follow-up ( P < .001), and the AOFAS Ankle-Hindfoot Scale from 63.5 ± 8.5 to 85.8 ± 4.8 points ( P < .001). The radiographic measurements significantly improved in terms of the preoperative vs final angles of 8.9 ± 5.3 vs 15.2 ± 3.6 degrees for calcaneal pitch ( P < .001), 20.5 ± 9.2 vs 4.9 ± 4.8 degrees for Meary angle ( P < .001), 46.5 ± 5.2 vs 41.9 ± 3.2 degrees for lateral talocalcaneal angle ( P < .001), 23.9 ± 8.5 vs 3.9 ± 3.1 degrees for talonavicular coverage angle ( P < .001), and 18.2 ± 9.2 vs 7.3 ± 5.0 degrees for talus-first metatarsal angle ( P = .002). The CC joint subluxation percentage was 7.0% ± 5.4% preoperatively compared with 8.5% ± 2.4% at the final follow-up ( P = .101). No case showed progression of CC joint arthritis or CC joint subluxation (>15% CC joint subluxation percentage). One case showed transient sural nerve territory paresthesia, and 1 had pin tract infection. Three cases had lateral foot pain, which could be relieved by custom insoles. Conclusion: Modified extra-articular LCL as part of AAFD correction is a feasible alternative technique without subtalar joint invasion and may be associated with less CC joint subluxation compared with the Evans osteotomy. Level of Evidence: Level IV, retrospective case series.
Evaluation of denosumab in adult oncology patients for the prevention of skeletal related events across a large academic health system
Authors: Sproat Michelle R. , Burton Bradley , Burdalski Catherine , Porter Timothy , Proctor Celia , Goldenhorn Michael , Andoh Kofi , Gilmore Steven 
Published: November 2021

Introduction Denosumab (Xgeva®) and zoledronic acid (Zometa®) are widely utilized for prevention of skeletal related events (SREs) in oncology patients. Drug costs, renal function, ease and logistics of administration, and adverse effect profile are factors frequently considered by patients and/or providers when selecting an optimal agent. Given the significantly higher drug cost of denosumab compared to zoledronic acid, an evaluation of our institution's denosumab use and investigation into opportunities to shift denosumab administrations to zoledronic acid and/or to lower cost sites-of-care was warranted. Methods A single-center, multi-site, retrospective, observational analysis of the electronic medical record (EMR) was conducted for adult oncology patients who received denosumab 120 mg for prevention of SREs from October 1st, 2018 to September 30th, 2019 at three institutions within our health system. Additional information was collected to characterize the patient population based on cancer diagnosis, renal function, and concomitant calcium and vitamin D supplementation. Our primary objective was to evaluate if the use of denosumab met current formulary restrictions of the health system. Results In total, 304 adult oncology patients received 1411 doses of denosumab for the prevention of SREs. The majority of reviewed patients had a primary oncology diagnosis of breast (35%) or lung (24%) cancer. Of the patients who received denosumab, 278 (93%) met the health system's current formulary restrictions. The majority of patients who did not meet formulary restrictions were those with multiple myeloma (MM) (20/22; 91%). Of the 304 patients reviewed, 70 had the appropriate parameters in the EMR to calculate creatinine clearance (CrCl) using Cockcroft-Gault Equation. Of those 70 patients, 59 (84%) would have been eligible to receive zoledronic acid instead of denosumab given that their CrCl >30 mL/min with no documented intolerance to bisphosphonates. Concurrent use of calcium and vitamin D is recommended when using denosumab. Based on the most recent prior to admission (PTA) medication list obtained from the 304 patients evaluated, 222 (73%) had both calcium and vitamin D listed as “taking”. Conclusions Within our health system, denosumab is restricted to those who meet formulary restrictions. Additional education is recommended to help limit the use of denosumab, specifically in MM, to reduce drug costs when zoledronic acid is also an appropriate first-line agent.
Timing and burden of persistent critical illnessin UK intensive care units: An observational cohort study
Authors: Harrison David A , Creagh-Brown Ben C , Rowan Kathryn M 
Published: November 2021

Background Persistent critical illness is a recognisable clinical syndrome defined conceptually as when the patient’s reason for being in the intensive care unit (ICU) is more related to their ongoing critical illness than their original reason for admission. Our objectives were: (1) to assess the day in ICU on which chronic factors (e.g., age, gender and comorbidities) were more predictive of survival than acute factors (e.g. admission diagnosis, physiological derangements) measured on the day of admission; (2) to assess the consistency of this finding across major patient subgroups and over time and (3) to compare case mix characteristics and outcomes for patients determined to develop persistent critical illness (based on ICU length of stay) with other patients. Methods Observational cohort study using a high-quality clinical database from the national clinical audit of adult critical care. 217 adult ICUs in England, Wales and Northern Ireland. 835,946 adult patients admitted to participating ICUs between 1 April 2009 and 31 March 2016. The main outcome measure was mortality at discharge from acute hospital. Results We fitted two statistical models (‘chronic’ and ‘acute’) and updated these based upon patients with an ICU length of stay of at least 1, 2, etc., up to 28 days. The discrimination of the chronic model first exceeded that of the acute model on day 11. Patients with longer stays (>10 days) comprised 9% of admissions but used 45% of ICU bed-days. After a mean ICU length of stay of 22 days and a subsequent 28 days in hospital, 30% died. Conclusions Persistent critical illness is commonly encountered in clinical practice and is associated with increased healthcare utilisation and adverse outcomes. Improvements in our understanding of the longer term outcomes and in the development of tools to aid prognostication are urgently required – for humane as well as health economic reasons.
Nuclear receptors: a bridge linking the gut microbiome and the host
Authors: Wang Zixuan , Chen Wei-Dong , Wang Yan-Dong 
Published: November 2021

Abstract
Background
The gut microbiome is the totality of microorganisms, bacteria, viruses, protozoa, and fungi within the gastrointestinal tract. The gut microbiome plays key roles in various physiological and pathological processes through regulating varieties of metabolic factors such as short-chain fatty acids, bile acids and amino acids. Nuclear receptors, as metabolic mediators, act as a series of intermediates between the microbiome and the host and help the microbiome regulate diverse processes in the host. Recently, nuclear receptors such as farnesoid X receptor, peroxisome proliferator-activated receptors, aryl hydrocarbon receptor and vitamin D receptor have been identified as key regulators of the microbiome-host crosstalk. These nuclear receptors regulate metabolic processes, immune activity, autophagy, non-alcoholic and alcoholic fatty liver disease, inflammatory bowel disease, cancer, obesity, and type-2 diabetes.

Conclusion
In this review, we have summarized the functions of the nuclear receptors in the gut microbiome-host axis in different physiological and pathological conditions, indicating that the nuclear receptors may be the good targets for treatment of different diseases through the crosstalk with the gut microbiome.
Organization and expression analysis of 5S and 45S ribosomal DNA clusters in autotetraploid Carassius auratus
Authors: Zhao Chun , Zhang Yuxin , Qin Huan , Wang Chongqing , Huang Xu , Yang Li , Yu Tingting , Xu Xidan , Luo Xiang , Qin Qinbo , Liu Shaojun 
Published: November 2021

Abstract
Background
Autotetraploid Carassius auratus (4n = 200, RRRR) (abbreviated as 4nRR) is derived from whole genome duplication of Carassius auratus red var. (2n = 100, RR) (abbreviated as RCC). Ribosome DNA (rDNA) is often used to study molecular evolution of repeated sequences because it has high copy number and special conserved coding regions in genomes. In this study, we analysed the sequences (5S, ITS1-5.8S-ITS2 region), structure, methylation level (NTS and IGS), and expression level (5S and 18S) of 5S and 45S ribosomal RNA (rRNA) genes in 4nRR and RCC in order to elucidate the effects of autotetraploidization on rDNA in fish.

Results
Results showed that there was high sequence similarity of 5S, 5.8S and ITS1 region between 4nRR and RCC. This study also identified two different types of ITS2 region in 4nRR and predicted the secondary structure of ITS2. It turns out that both secondary structures are functional. Compared with RCC, there was no significant difference in NTS (5S rRNA) methylation level, but the expression level of 5S rRNA was lower in 4nRR, indicating that methylation had little effect on the expression level in 4nRR. IGS (45S rRNA) was hypermethylated in 4nRR compared to RCC, but the expression of 18S rRNA gene was no significantly different from that in RCC, indicating that methylation regulation affected gene expression in 4nRR.

Conclusion
The above studies initially revealed the effects of autotetraploidization on the structure and function of 5S and 45S rRNA in Carassius auratus, and provided a theoretical support for the systematic study of the evolution pattern and characteristics of rDNA in vertebrates.