bluuebunny/crossref_metadata_2025_split huggingface dataset:
Final Report on Clinical Outcomes and Tumor Recurrence Patterns of a Pilot Study Assessing Efficacy of Belinostat (PXD-101) With Chemoradiation for Newly Diagnosed Glioblastoma
Authors: Xu Karen , Ramesh Karthik , Huang Vicki , Gurbani Saumya S , Cordova J Scott , Schreibmann Eduard , Weinberg Brent D , Sengupta Soma , Voloschin Alfredo D , Holdhoff Matthias , Barker Peter B , Kleinberg Lawrence R , Olson Jeffrey J , Shu Hui-Kuo G , Shim Hyunsuk 
Published: June 2021

Abstract
PurposeGlioblastoma (GBM) is highly aggressive with poor prognosis. Belinostat is a histone deacetylase inhibitor with blood–brain barrier permeability, anti-GBM activity, and potential to enhance chemoradiation. The purpose of this clinical trial was to assess the clinical efficacy of combining belinostat with standard-of-care therapy for GBMs. Methods13 patients were enrolled in each of the control and belinostat cohorts. The belinostat cohort was given a belinostat regimen (500-750 mg/m2 1x/day x 5 days) every 3 weeks (weeks 0, 3, and 6 of RT). All patients received temozolomide and radiation therapy (RT). RT margins of 5-10 mm were added to generate clinical tumor volumes and 3 mm added to create planning target volumes. Patient outcomes included progression-free survival, overall survival (OS), and recurrence pattern analysis of enhancing tumor (rGTV). ResultsMedian OS was 15.8 months for the control cohort and 18.5 months for the belinostat cohort (p=0.53). The rGTVs in the control cohort occurred in areas that received higher radiation doses than that in the belinostat cohort. For those belinostat patients who experienced out-of-the field recurrence, tumors were detectable by spectroscopic MRI before RT. ConclusionThe median OS was slightly longer for the belinostat cohort than the control cohort but not statistically significant. Recurrence analysis suggests better in-field control with belinostat, suggesting a radio-sensitizing effect. This study highlights the potential of belinostat as a synergistic therapeutic agent for GBM treatment. It may be particularly beneficial to combine this radio-sensitizing effect with spectroscopic MRI-guided radiation therapy.
Computational Method for Solving Weakly Singular Fredholm Integral Equations of the Second Kind using an Advanced Barycentric Lagrange Interpolation Formula
Authors: Shoukralla Emil , Saber Nermin , Sayed Ahmed Yehia 
Published: June 2021

Abstract
In this study, we applied an advanced barycentric Lagrange interpolation formula to find the interpolate solutions of weakly singular ‎Fredholm integral equations of the ‎second kind. The kernel is ‎interpolated twice concerning ‎both variables and then is transformed into the product of five ‎matrices; two of them are monomial basis ‎matrices. To isolate the singularity of the kernel, we ‎developed two techniques based on a good choice of ‎different two sets of nodes to be distributed ‎over the integration domain. Each set is specific to one of the ‎kernel arguments so that the kernel ‎values never become zero or imaginary. The significant advantage of the ‎two presented ‎techniques is the ability to gain ‎‎access to an algebraic linear system equivalent to the interpolant solution without applying the collocation method. Moreover, the convergence in the ‎mean of the interpolant solution ‎and the maximum error norm estimation are studied. The ‎interpolate solutions of the illustrated four ‎examples are found strongly converging uniformly to the ‎exact solutions.
Autoimmune Hemolysis Anemia After Dihydroartemisinin and Piperaquine for Uncomplicated Plasmodium Falciparum Malaria
Authors: louvois marion , Simon Loic , Pomares Christelle , Jeandel P-Y. , Demonchy Elisa , Carles Michel , Delaunay Pascal , Courjon Johan 
Published: June 2021

Abstract
BackgroundMalaria is still an endemic disease in Africa with many imported cases in Europe. The standard treatment is intravenous artesunate for severe malaria and oral artemisinin-based combination therapy (ACT) for uncomplicated malaria. Delayed hemolytic anemia (DHA) after intravenous artesunate has been extensively described and guidelines recommend a biological monitoring until one month after the end of the treatment. The link with an autoimmune process is unsure. Nevertheless, cases with positive direct antiglobulin test (DAT) have been reported. Conversely, DHA is not recognized as an adverse effect of oral ACT. Previously, only two cases of DHA occurring after oral ACT without intravenous artesunate administration have been reported. Case presentationWe report the case of a 42 year old man returning from Togo. He was treated with dihydroartemisinin / piperaquine combination for an uncomplicated Plasmodium falciparum malaria. Nine days after the end of the treatment he developed hemolytic anemia with positive DAT. Eventually, the patient recovered after corticotherapy. ConclusionThis is the first case report of autoimmune hemolytic anemia after treatment with dihydroartemisinin and piperaquine.
Mid-term Impacts of Silvicultural Treatments on Soils and Understory Plant Diversity in Temperate Hardwood Forests of Quebec, Canada.
Authors: Jaeger Romain , Delagrange Sylvain , Aubin Isabelle , Joanisse Gilles , Raymond Patricia , Rivest David 
Published: June 2021

Abstract
Background: Short-term effects of silvicultural treatments on soil properties and understory vegetation in temperate hardwood forests are well documented, but few studies have examined longer term effects of treatment intensity. We hypothesized that short-term effects of silvicultural treatments on understory plant diversity do persist over the medium-term (20 years after treatment); the magnitude of these effects would be proportional to the intensity of canopy and soil disturbance.Methods: Soil properties (pH, total C and N, extractable P, exchangeable bases) and understory community diversity indices were measured in six experimental sites along a longitudinal gradient that covered different climatic and edaphic conditions in the yellow birch-sugar maple bioclimate domain. Reference condition, i.e. control forest with no anthropogenic disturbance for at least 80 years (CON) were compared to twenty years old regeneration treaments representing a gradient of canopy and soil disturbance intensity: single-tree selection cuts (SIN); group-selection cuts (GRP); and group-selection cuts with scarification (GRPS). Results: Geographic location of sites explained more variation in soil properties and community composition than did treatments. Species richness in both group-selection treatments was higher than that in CON forests. However, understory plant equitability and beta diversity among sites in GRP and GRPS were lower than in SIN and CON forests. More intense treatments (GRP and GRPS) increased the relative occurrence of vegetatively reproducing heliophilic plants, a trait syndrome associated with adaptations to disturbed environments. These treatments also contributed to the medium-term persistence of recalcitrant competitor species (e.g., Rubus idaeus, Prunus pensylvanica) whereas soil scarification appears to have negative sustained effects on species known to be sensitive to regeneration treatments (e.g. Monotropa uniflora, Dryopteris spinulosa).Conclusion: Of the treatments studied, single-tree selection cutting appears to be the most appropriate silvicultural treatment for maintaining soil functions and heterogeneous understory plant communities with compositions and structures similar to natural forests, while more intense treatments rather maintain and expand species that are better adapted to a wider range of environmental conditions, including open environments.
Molecular Insights into Tumor Targeted Therapy by Carrier-Free Lycorine Nanoparticles in Vitro and in Vivo
Authors: Zhou Shiyue , Qiu Yuling , Liu Rui , Yin Shuangshuang , Shao Yingying , Wu Song , Chen Qian , Wang Tao , Du Bo , Yu Haiyang 
Published: June 2021

Abstract
Lycorine (Ly) is a promising natural compound with extensive antitumor activities. However, due to poor aqueous solubility and low bioavailability, the research and development of Ly anticancer drugs has been greatly restricted. Recently, the carrier-free nanoparticles have emerged as an outstanding drug delivery system. In this study, we prepared a DSPE-PEG modifying Ly nanoparticle (DS-Ly NPs) to overcome these drawbacks. We find that compared with Ly, DS-Ly NPs can significantly inhibit cell viability. Meanwhile, DS-Ly NPs treatment results in higher promotion of apoptotic and autophagic capacities, as well as inhibition of migration and invasion. Furthermore, DS-Ly NPs exhibits a better antitumor effect in AOM/DSS induced colorectal tumors and orthotopic hepatocellular tumors than Ly in repression of multiple oncogenic processes, which may benefit from the advantages of carrier-free nanoparticle. Beside, we showed that DS-Ly NPs can prolong the blood circulation time better than Ly. Taken together, these results have demonstrated that carrier-free nanoparticle provides a new therapeutic strategy for treating cancer.
The Trend of Combined Modality Treatment and its Outcomes in Elderly Patients With Primary CNS Lymphoma; A 12-Year Population-Based Analysis Using Propensity Score
Authors: Samhouri Yazan , Ali Moaath K Mustafa , Jayakrishnan Thejus , Bakalov Veli , Fazal Salman , Khan Cyrus , Wegner Rodney E , Lee Seung Tae , Lister John 
Published: June 2021

Abstract
BackgroundThe addition of radiation to chemotherapy in elderly patients with PCNSL remains controversial. Our objective was to assess the trend of combined modality treatment (CMT) and compare its survival with chemotherapy alone and radiation alone in non-HIV patients. MethodsWe identified 6,537 patients who received single treatment modality, combined modality treatment, or no treatment at all between 2004 and 2015 from the National Cancer Database. Factors affecting treatment selection were investigated using a logistic regression model. Annual percentage change (APC) was calculated to assess the trend of CMT use. A propensity score weighting methodology was used to compare survival outcomes. FindingsOnly 12.8% of patients received CMT, and this proportion steadily declined between 2004 (17.7%) and 2015 (8.7%), with APC of -6.0% (95% CI -8.0 to -4.0, p-value <0.001) during the 12 years. Apart from classical prognostic factors (age and comorbidities), treatment selection was significantly influenced by sex, facility type, degree of urbanization, and type of insurance. CMT had improved survival (median overall survival 19.5 months (95% CI 15.7-22.8)) compared with single-modality treatment. This effect was more prominent in the first year. Conclusion Socioeconomic factors affect the selection of treatment in elderly patients with PCNSL that can alter outcomes. CMT is falling out of favor in this patient population due to the risks of neurotoxicity. Further work should focus on developing strategies that minimize toxicity and access disparities without compromising survival
Development of Process and Data Centric Inference System for Enhanced Production of L-Asparaginase From Halotolerant Bacillus Licheniformis PPD37
Authors: Patel Payal , Gosai Haren B , Panseriya Haresh , Dave Bharti 
Published: June 2021

Abstract
The present study aims at bioengineering of medium components using – data and process centric approaches for enhanced production of L-asparaginase, an important biological molecule, by halotolerant Bacillus licheniformis PPD37 strain. To achieve this, first significant medium components were screened followed by optimization of a combination of media components and culture conditions such as L-asparagine, MgSO4, NaCl, pH and temperature. Optimization study was carried out using statistical models such as response surface methodology (RSM) – process centric and artificial neural network (ANN) – data centric approaches. The production improved from 2.86 U/mL to 17.089 U/mL, an increase of approximately 6-times of the unoptimized L-asparaginase production. On comparing RSM and ANN models for optimised L-asparaginase production based on R2 value, mean absolute percentage error (MAPE), root mean square error (RMSE), and mean absolute deviation (MAD) values, the ANN model emerged as the superior one. As this is the first report to the authors best knowledge on development of inference system using RSM and ANN models for enhanced L-asparaginase production using a halotolerant bacteria, this study could lead to more in-depth and large-scale L-asparaginase production.
Kinematics Model Approach to Energy Efficiency in Sustainable Manufacturing
Authors: He Bin , Xu Fuze , Zhang Pengchang 
Published: June 2021

Abstract
As the energy efficiency is a worldwide topic for sustainability in sustainable manufacturing, the industry ought to undertake the responsibility in a low-energy manner. For energy efficiency, this paper proposed a novel lightweight Non-holonomic Spherical Underactuated Robot (NSUR) with lower energy consumption and fewer actuators than traditional robotics. The kinematics of a robot refers the motion analysis, such as coordinates, velocity, and acceleration. However, current researches always focus on the holonomic full-actuated robot. This paper is devoted to a kind of novel NSUR and its theoretical kinematics analysis model. After NSUR was introduced, the kinematic representation of NSUR was discussed. A pair inverse and forward kinematics analysis of NSUR was put forward in detail. The kinematic analysis of joint of underactuated robot, as the application of NSUR, is applied to explain and verify this methodology. The measurements and comparisons of energy efficiency between NSUR and traditional robotics are also derived in detail.
A Procedure for Dex-induced Gene Transactivation in Arabidopsis Ovules
Authors: Schubert Jasmin , Li Yanru , Mendes Marta A. , Dickinson Hugh , Baroux Célia 
Published: June 2021

Abstract
Background: Elucidating the genetic and molecular control of plant reproduction requires the deployment of functional approaches based, for instance, on reverse or forward genetic screens. The loss-of-function of essential genes, however, may lead to plant lethality prior to reproductive developmentt or to the formation of sterile structures before the organ-of-interest can be analysed. In these cases, inducible approaches that enable a spatial and temporal control of the genetic perturbation are extremely valuable. Genetic induction in reproductive organs, such as the ovule, deeply embedded in the flower, is a delicate procedure that requires both optimization and validation. Results: Here we report on a streamlined procedure enabling reliable induction of gene expression in Arabidopsis ovule and anther tissues using the popular pOP/LhGR Dex-inducible system. We demonstrate its efficiency and reliability using fluorescent reporter proteins and histochemical detection of the GUS reporter gene. Conclusion: The pOP/LhGR system allows for a rapid, efficient and reliable induction of transgenes in developing ovules without compromising developmental progression. This approach opens new possibilities for the functional analysis of candidate regulators in sporogenesis and gametogenesis, which are otherwise affected by early lethality of conventional, stable mutants.
Missed Nursing Care in Intensive Care Patients Subjected to Interhospital Capacity Transfers: A Retrospective Matched Case–Control Chart Review
Authors: Karlsson Jonas , Fridh Isabell , Schildmeijer Kristina , Hagiwara Magnus Andersson 
Published: June 2021

Abstract
Background The number of patients undergoing an interhospital intensive care unit-to-unit capacity transfer has dramatically increased. These transfers are complex, pose a risk for the patients and have been linked to increased intensive care unit length of stay and mortality, but the reasons for this are not known. We hypothesised that there was a difference in the incidence of missed nursing care among patients subjected to capacity transfer compared with patients not subjected to any transfer during their intensive care stay. Methods A retrospective case–control chart review was conducted on adult patients who between January 1, 2009, and January 31, 2020, underwent an interhospital intensive care unit-to-unit capacity transfer. We applied a matched control group by 1:2 matching. Missed nursing care was based on four variables: mobilisation, tooth brushing, oral care and nutrition. Data were retrieved from the local database and the patient’s medical charts at two general level 3 ICUs. Results The case group (n = 63) received significantly less mobilisation ( p < 0.05), mean 5.94 (2.36), compared with the control group (n = 126), mean 7.74 (2.96). In a subanalysis of the patients treated with invasive positive pressure ventilation and noninvasive positive pressure ventilation, the case group (n = 56) was found to receive significantly less oral care ( p < 0.05), median 3.50 (1.00–6.00), compared with the control group (n = 80), median 5.00 (2.00–7.75). None of the other variables were significantly related to interhospital intensive care unit-to-unit capacity transfers. Conclusion In critically ill patients, interhospital intensive care unit-to-unit capacity transfers were associated with missed nursing care. Future studies, focusing on capacity transfers should consider missed nursing care when the causes of increased intensive care unit length of stay and mortality are to be investigated.
Evaluation of Antioxidant And Anti-Ulcerogenic Effects of Eremurus Persicus (Jaub &amp; Spach) Boiss Leaf Hydroalcoholic Extract On Ethanol-Induced Gastric Ulcer In Rats
Authors: Beiranvand Mohammad , Bahramikia Seifollah , Dezfoulian Omid 
Published: June 2021

Abstract
This study aimed to investigate the antioxidant and protective effect of Eremurus persicus (Jaub & Spach) leaf hydroalcoholic extract (EPE) in preventing gastric ulcers induced by ethanol in rats. Wistar rats weighing 180-220 g were randomly divided into five groups, included normal group, ethanol consumption group, ranitidine treatment experienced group, the recipient rats prepared by dose of 250 mg/kg plant extract, and the last group recipient the dose of 500 mg/kg plant extract. The gastric ulcer was induced by feeding 1 ml of 96% ethanol to each animal. The gastric ulcer index (UI), pH, oxidative stress parameters, and histopathological changes in all stomachs were measured. Pre-treatment of ethanol-induced rats with the EPE reduced (P<0.05) the ulcer index and gastric juice pH, compared to ethanol intake rats. Additionally, pre-treatment with EPE at a dose-dependent manner alleviated the gastric oxidative stress injury in rats by increasing CAT activity, tissue NO• and GSH levels. EPE also was able to decrease the levels of ROS, MDA, PCO and serum NO•. According to the results, it can be concluded that pre-treatment with EPE prevents the formation of gastric ulcers caused by ethanol, which can be attributed to the antioxidant activity of plant polyphenols compounds.
Stratification At The Health District Level And Targeting of Malaria Control Interventions In Mali
Authors: Cissoko Mady , Magassa Mahamadou , Sanogo Vincent , Ouologuem Abdoulaye , Sangaré Lansana , Diarra Modibo , Bationo Cedric Stephane , Dolo Amagoron dit Mathias , Bah Mamadou D. , Doumbia Sidy , Coulibaly Mamadou B. , Traoré Diahara , Sidibé Boubacar , Noor Abdisalan M. , Cissé Idrissa , Sacko Moussa , Gaudart Jean , Sagara Issaka 
Published: June 2021

Abstract
IntroductionMalaria has been the leading cause of morbidity and mortality for several decades in Mali, with an increase from 2017 to 2020 (2,884,837 confirmed cases and 1,454 deaths). On the recommendation of the World Health Organization (WHO) and in the interests of efficient use of resources, Mali has begun a process of stratifying the health districts to target malaria control strategies.MethodMalaria, entomological and environmental data were collected through the local health information system (LHIS), the Demographic and Health Survey (DHS 2018), research institutions and MALI-METEO services. The WHO has recommended stratification at the district level consisted of assigning each district to one of 4 classes according to criteria based on incidence adjusted for attendance rate. Variables associated with monthly malaria incidence at the district level were identified using a general additive non-linear regression model.ResultsFrom 2017 to 2019, the median incidence across 75 health districts of Mali was 129.34 cases per 1,000 person-year (IQR=86.48). The results showed different periods of high malaria transmission in health districts level and durations varying from 2 to 6 months, showing a double peak for some health districts, which were located in the flooded areas. environmental variables such as rainfall, vegetation index (NDVI), maximum temperature and relative humidity were significantly associated at malaria incidence with a lag of around one month. A strata defines a geographical area with similar epidemiological, environmental and socio-economic factors. Stratification resulted in 12 health districts of very low transmission, 19 low transmission, 20 moderate transmission and 24 in high transmission areas. The number of rounds of season malaria chemoprevention will be based on the number of months in the high transmission period.ConclusionThis first stratification in Mali will allow targeting malaria control strategies. This approach will be dynamic and revised yearly in order to integrate information from the national epidemiological surveillance.
Anonymous Online Cognitive Behavioral Therapy for Sleep Disorders in Shift Workers – A Study Protocol for a Randomized Controlled Trial
Authors: Retzer Lukas , Feil Monika , Reindl Richard , Richter Kneginja , Lehmann Robert , Stemmler Mark , Gräßel Elmar 
Published: June 2021

Abstract
Background: Many shift workers suffer from sleep issues, which negatively affect quality of life and performance. Scientifically evaluated, structured programs for prevention and treatment are scarce. We developed an anonymous online cognitive behavioral therapy for insomnia (CBT-I) program. After successful completion of a feasibility study, we now start this prospective, randomized, controlled superiority trial to compare outcomes of two parallel groups, namely an intervention group and a waiting-list control-group. Additionally, we will compare these outcomes to those of a face-to-face CBT-I outpatient sample.Methods: Collaborating companies will offer our anonymous online intervention to their shift-working employees. Company physicians and counseling services will screen those interested for inclusion and exclusion criteria. Participants will receive access to our online service, where they will complete psychometric assessment and receive random assignment to either the intervention group or the waiting-list control group. Participants and providers will be aware of the group assignment. We aim to allocate at least N = 60 participants to the trial. The intervention consists of psychoeducation, sleep restriction, stimulus control, relaxation techniques, and individual feedback delivered via four e-mail contacts. During the intervention, as well as during the waiting period, participants will fill out weekly sleep diaries. Immediately after completion of the program, the post-intervention assessment takes place. Participants in the control group will be able to participate in the program after all study assessments. To recruit an additional sample, collaborating outpatient sleep clinics will provide six sessions of standard face-to-face CBT-I to an ad-hoc sample of shift working patients. We expect both the online and the face-to-face CBT-I interventions to have beneficial effects compared to the control group on the following primary outcomes: self-reported symptoms of depression and insomnia, sleep quality, and daytime sleepiness. Conclusions: The online intervention allows shift workers to follow a CBT-I program independently of their working schedule and location. Forthcoming results might contribute to further improvement of prevention and therapy of sleep issues in shift workers.