bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovated Banana Fiber Nonwoven Reinforced Polymer Composites: Effects of Pre- and Post-treatments on Physical and Mechanical Properties
Authors: Motaleb K.Z.M. Abdul , Ahad Abdul , Laureckiene Ginta , Milasius Rimvydas 
Published: August 2021

Abstract
Four types of nonwovens were prepared from different sections of the banana tree e.g., outer bark (OB), middle bark (MB), inner bark (IB) and midrib of leaf (MR) by wet laid web formation. They were reinforced on two different types of matrices e.g., epoxy (E) and polyester (P) to make eight variants of composites. Different concentration (5–15%) of NaOH and water repellent (WR); and different doses (100-500krd) of gamma radiation were applied in different stages of process. The properties like water absorbency, tensile strength (TS), flexural strength (FS) and elongation at break (Eb%) were investigated. OB composites were exhibited higher water absorbency, TS and FS but lower Eb% than other types of composites. Epoxy composites were found to have 16% lower water absorbency, 41.2% higher TS and 39.1% higher FS than polyester composites on an average. Alkali treatment reduced the water absorbency by 32%; improved the TS by 71%; improved the FS by 87% on an average at 15% NaOH. Water repellent treatment (on alkali treated composites) decreased the absorbency by 63% at 10% WR but increased 6.3% at 15% WR. Gamma radiation improved the TS of 30% and FS of 35% on an average at a dose of 100krd for IB and 200krd for other composites. Further increment of dose reduced both the FS and TS.
Genetic Stability in Melon Transformation System: Assessment by Flow Cytometry and ISSR Markers
Authors: Raji Mohammad Reza , Farajpour Mostafa 
Published: August 2021

Abstract
Genetic instability in melon species sometimes occurs as a result of in vitro tissue culture and transformation systems. This study describes a new regeneration technique for agrobacterium-mediated co-culture of muskmelon explants (Cucumis melo L. c.v. ‘Khatooni’). Here, no genetic instability was observed in positive PCR regenerants. 4-day-old cotyledonary explants had been infected with LBA4404 Agrobacterium suspensions. The co-cultivation occurred in the presence of 100mg/l rifampicin and 50mg/l kanamycin. The bacteria contained a binary vector pBI121 carrying nopaline synthase by the promoter-neomycin phosphotransferase gene. The regeneration succeeded 65% in selective MS medium containing N6-benzylaminopurine (600 µg/l), β-naphthoxyacetic acid (25 µg/l) and 50mg/l kanamycin in inoculated 4-day-old cotyledonary explants. According to the polymerase chain reaction analysis of neomycin phosphotransferase II gene, transformation was merely successful (8.4%), indicating a substantial miss on a large number of regenerated plants in the selective medium, as a consequence of PGR and antibiotic imbalances. Inter Single Sequence Repeat markers and flow cytometry analyses were used for evaluating the genetic stability and ploidy level of transplants, respectively. The integrated approach underlined that Agrobacterium inoculation and plant growth regulators were successfully combined in vitro to enable muskmelon transformation.
Sarcomatoid Hepatocellular Carcinoma With Skull Base Metastasis: A Case Report
Authors: Lin Chen , Chen Bo-An , Jung Shih-Ming , Lee Cheng-Chi 
Published: August 2021

Abstract
Background

Sarcomatoid hepatocellular carcinoma (SHC) is a relatively malignant tumor due to its recurrence and metastasis. Although metastatic SHC has been reported, skull base metastasis has not yet been documented.
Case presentation:

We herein report on a 51-year-old male with left throbbing headache and cranial nerve neuropathies. Magnetic resonance imaging revealed an extradural lesion of over 4 cm involving the jugular foramen, hypoglossal canal, clivus and the atlas. An endoscopic endonasal approach (EEA) was adopted for tissue biopsy and decompression, and the symptoms of the patient improved significantly after the surgery.
Conclusions

SHC invading the skull base is an extremely rare circumstance. For such extradural lesions, EEA is the most applicable and promising treatment approach.
Evaluation of Thyroglobulin Antibody Normalization in Papillary Thyroid Cancer Patients Receiving High-Dose I-131 Therapy
Authors: Hwang Sang Hyun , Jo KwanHyeong , Kang Chun Goo , Wang Jiyoung , Cho Hojin , Kang Won Jun , Cho Arthur 
Published: August 2021

Abstract
Purpose: Thyroglobulin antibody (TgAb) elevation after I-131 ablation may be difficult to evaluate in cases of recurrence, especially in high-risk patients. This study aimed to evaluate factors contributing to TgAb normalization in papillary thyroid cancer patients receiving high-dose I-131 therapy. Methods: From September 2009 to June 2012, 98 papillary thyroid cancer patients treated with 150 mCi radioactive iodine (RAI) were retrospectively enrolled. Early (3 day) and Delayed (7 day) post-RAI neck counts and reduction ratios were measured and correlated with clinical and pathologic findings. Patients with normal neck ultrasound and undetectable level of serum thyroglobulin (<0.1 ng/mL) and TgAb (<10 IU/mL) were defined as having successful ablation.Results: Thirty-five patients (35.7%) had thyroiditis and 28 (28.6%) achieved ablation success. The thyroiditis group had lower neck counts in both Early and Delayed whole-body scans (WBS), and higher reduction rates than the thyroiditis-absent group. In the ablation success group, Early and Delayed neck counts were significantly higher and the reduction rate of RAI was lower than those in the ablation failure group (p < 0.05). In multivariable analysis, Delayed neck count was the only significant factor for predicting ablation failure (odds ratio = 54.37, 95% confidence interval = 1.33-14.32; p = 0.015).Conclusion: I-131 uptake in the remnant thyroid gland and thyroiditis are factors that indicate TgAb normalization and ablation success in thyroid cancer patients receiving high-dose I-131 therapy.
The influence of primary care quality on nursing home admissions in a multimorbid population with and without dementia in Germany: A retrospective cohort study using health insurance claims data
Authors: Seibert Kathrin , Stiefler Susanne , Domhoff Dominik , Wolf-Ostermann Karin , Peschke Dirk 
Published: August 2021

Abstract
Background
Multimorbidity poses a challenge for high quality primary care provision for nursing care-dependent people with (PWD) and without (PWOD) dementia. Evidence on the association of primary care quality of multimorbid PWD and PWOD with the event of a nursing home admission (NHA) is missing. This study aimed to investigate the contribution of individual quality of primary care for chronic diseases in multimorbid care-dependent PWD and PWOD on the duration of ongoing residence at home before the occurrence of NHA.
Methods
We conducted a retrospective cohort study among elderly care-dependent PWD and PWOD in Germany for six combinations of chronic diseases using statutory health insurance claims data (2007–2016). Primary care quality was measured by 21 process and outcome indicators for hypertension, diabetes, depression, chronic obstructive pulmonary disease and heart failure. The primary outcome was time to NHA after initial onset of care-dependency. Multivariate Cox proportional hazard models were used to compare the time-to-event between PWD and PWOD.
Results
Among 5876 PWD and 12,837 PWOD 5130 NHA occurred. With the highest proportion of NHA for PWD with hypertension and depression and for PWOD with hypertension, diabetes and depression. Average duration until NHA ranged from 6.5 to 8.9 quarters for PWD and from 8.1 to 13.5 quarters for PWOD. Adjusted analyses show consistent associations of the quality of diabetes care with the duration of remaining in one's own home regardless of the presence of dementia. Process indicators assessing guideline-fidelity are associated with remaining in one's home longer, while indicators assessing complications, such as emergency inpatient treatment (HR = 2.67, 95% CI 1.99–3.60 PWD; HR = 2.81, 95% CI 2.28–3.47 PWOD) or lower-limb amputation (HR = 3.10, 95% CI 1.78–5.55 PWD; HR = 2.81, 95% CI 1.94–4.08 PWOD) in PWD and PWOD with hypertension and diabetes, increase the risk of NHA.
Conclusions
The quality of primary care provided to care-dependent multimorbid PWD and POWD, influences the time individuals spend living in their own homes after onset of care-dependency before a NHA. Health care professionals should consider possibilities and barriers of guideline-based, coordinated care for multimorbid care-dependent people. Further research on quality indicator sets that acknowledge the complexity of care for multimorbid elderly populations is needed.
Development of Caryopsis and Starch Physicochemical Properties in Different Grain Positions of Wheat Spikelets
Authors: Wang Leilei , Yu Xurun , Zhang Yong , Wu Yunfei , Xiong Fei 
Published: August 2021

Abstract
Background: Spikelets at different spike positions and the caryopsis at different grain positions grow and develop differently. The caryopsis development and physicochemical properties of starch at different grain positions (the first, second, and third grain positions: G1, G2, and G3) of wheat spikelets were investigated in this study. Results: During the development process, the thickness of both dorsal and abdomen pericarp 8 days after anthesis (DAA) followed the sequence G2 < G1 < G3. However, at 14 DAA the thickness followed the dorsal sequence of G1 < G2 < G3 and the abdomen sequence of G2 < G1 < G3. At 20 and 30 DAA, no difference existed in the pericarp thickness of each grain. The accumulation quantities before 20 DAA varied with starch and protein of endosperm cell in the order G1 > G2 > G3. In mature caryopsis, the caryopsis size and weight indicate that G1 = G2 > G3. The starch content followed the order G1 > G2 > G3, while the essential amino acid, the total amino acid, and the protein content followed the order G2 > G1 > G3. The apparent amylose content followed the sequence G3 > G2 > G1, and A-type starch content followed G3 > G1 > G2. The amorphous ratio followed the order G2 > G1 > G3, whereas the double-helix ratio and the relative crystallinity exhibited the opposite trend. The order of the final degree of hydrolysis through AAG, PPA, and HCL was G2 > G1 > G3. Conclusions: The different material contents were possibly due to the short development time of caryopsis, and the difference in starch physicochemical properties between G2 and the other grain positions might be related to the components and structural characteristics of starch.
Giant Left Anterior Descending Artery Aneurysm in a Patient With Active Systemic Lupus Erythematosus ：A Case Report Short Title: Rare Complications of Systemic Lupus Erythematosus
Authors: Yao Zipeng , Long Yanhong , Zong Zheng , Wang Lin 
Published: August 2021

Abstract
BackgroundAlthough not common, coronary artery aneurysms (CAAs) can develop to over 8 mm in diameter to become giant CAAs. In the context of systemic lupus erythematosus (SLE), autoantibody- and immune complex-mediated atherosclerosis is believed to be the most prevalent cause of aneurysm.Case presentationwe report the case of a 53-year-old female SLE patient who presented to our hospital with radiating chest pain. Coronary angiography revealed a giant aneurysm in the middle segment of the left anterior descending artery (LAD) and distal subtotal occlusion in the left circumflex artery (LCX). Laboratory testing also identified risk factors such as an abnormal pulmonary enzyme profile, dyslipidemia, and nephritis parameters.To prevent thromboembolism, anticoagulation and antiplatelet therapy were administered. In addition, one stent was implanted at the distal end of the LCX and repeated coronary angiography verified restoration of TIMI grade III flow.The patient was discharged with resolved chest pain. During 6 months of follow-up, the patient is in good health.Conclusions﻿Our case study, together with 16 recent comparable reports, emphasizes the need for coronary aneurysm screening in SLE patients. It is necessary that thromboembolism, anticoagulation and antiplatelet therapy were administered for CAA.
Genetic analyses of SERPINA5 in Alzheimer’s disease
Authors: Matchett Billie J. , Lincoln Sarah J. , Baker Matt , Tamvaka Nikoleta , Cabrera-Rodriguez Janisse , Labuzan Sydney A. , Helminger Jacqueline , Hinkle Kelly M. , Duara Ranjan , Graff-Radford Neill R. , Ertekin-Taner Nilüfer , Ross Owen A. , Rademakers Rosa , Dickson Dennis W. , Murray Melissa 
Published: August 2021

Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is the most common cause of dementia. Our previous studies have shown that increased expression of the SERPINA5 gene is associated with hippocampal vulnerability in AD, and that the SERPINA5 protein binds to tau and co-localizes within neurofibrillary tangles. To determine if genetic variants in the SERPINA5 gene may be contributing to this phenotype, we sequenced 103 autopsy-confirmed young-onset AD cases with a positive family history of cognitive decline. We observed one individual with a rare missense variant (rs140138746) in the SERPINA5 gene, resulting in an amino acid change (p.E228Q). We screened a further 1170 neuropathologically diagnosed AD cases and identified an additional 5 carriers of this variant, resulting in an allelic frequency of 0.002141 within our AD validation cohort, which was comparable to online genomic databases. Although not significant, SERPINA5 p.E228Q variant carriers were found to be younger at age of onset and age of death than non-carriers. SERPINA5 p.E228Q variant carriers had a longer disease duration than non-carriers, which approached significance. To further elucidate possible neuropathologic contributions of the SERPINA5 p.E228Q variant, we carried out descriptive neuropathologic burden analysis on a variant carrier that was matched to a non-carrier for age, sex, disease duration, Braak tangle stage, TDP-43 positive status, and who possessed an APOE ε4 risk allele. Interestingly, SERPINA5 burden was lower in the SERPINA5 p.E228Q carrier than the non-carrier in 9 corticolimbic brain regions studied, which exaggerated the tau:SERPINA5 immunohistochemical ratio. The SERPINA5 p.E228Q carrier was observed to have more severe neuronal loss in several brain regions compared to the non-carrier. Together, we cautiously interpret these findings to suggest that the SERPINA5 p.E228Q variant may stall tangle maturity and slow AD disease progression, thus prolonging disease duration in these individuals.
Using Online Spaces to Recruit Kenyan Queer Womxn and Trans Men in Restrictive Offline Settings
Authors: Haase Stephanie , Zweigenthal Virginia , Müller Alex 
Published: August 2021

Abstract
BackgroundUnderstanding and addressing healthcare and service delivery inequalities is essential to increase equity and overcome health disparities and service access discrimination. While tremendous progress has been made towards the inclusion of sexual and gender minorities in health and other research, gaps still exist. Innovative methods are needed to close these. This case study describes and reflects on using online-based data collection to ascertain sexual health decision-making and health service utilisation among Kenyan queer womxn and trans men. Methods: Case study The study used a mixed-methods approach in two phases with triangulated quantitative and qualitative elements. Both elements used web-based technology to gather data. ResultsUsing online spaces to recruit and collect data from queer womxn and trans men exceeded expectations. A total of 360 queer womxn and trans men responded to the digitally distributed survey, and 33 people, queer womxn and trans men, as well as key informants, participated in the interviews, which were primarily conducted on Zoom and Skype. The case study analyses the risks and benefits of this approach and concludes that online sampling approaches can mitigate risks and enable effective and safe sampling of a marginalised group in a restrictive legal setting: Kenyan queer womxn and trans men. ConclusionUsing online spaces when researching marginalised populations may could effectively overcome risks around stigma, discrimination and violence. It can be an effective way to better understand these populations’ healthcare needs. Factors contributing to success included building trusting relationships with key members of the community, strategic and opportune timing, a nuanced understanding of the mobile landscape, and careful safety and security measures. However, it should be noted that conducting research online could increase the risk of further marginalising and excluding those without access to web-based technology.
Turkish cases of Mabry Syndrome with a novel homozygous mutation in PGAP2 gene
Authors: Jaiswar Sandeep , Kartal Ayşe 
Published: August 2021

Abstract
Hyperphosphatasia with mental retardation syndrome is a genetic disorder. We report two siblings aged three years and fourteen years who were investigated for global development delays, seizures and dysmorphic features. A novel missense variant, c.1003G>A (p. Ala335 Thr chr11.3,846,572 NM_001256236.1), in PGAP2 gene was identified using whole-exome sequencing. We highlight the significance of elevated alkaline phosphatase in patients with certain dysmorphic features, can lead to the diagnosis of hyperphosphatasia with mental retardation syndrome using exome sequencing.
Thermal management of photovoltaic panel with nano-enhanced phase change material at different inclinations
Authors: SASIDHARAN UNNIKRISHNAN KARTHAMADATHIL , BANDARU ROHINIKUMAR 
Published: August 2021

Abstract
Photovoltaic (PV) panel, coupled with phase change material (PCM), has attracted broad attention for the panel's thermal management. Despite the higher energy storage capability of PCMs, the main disadvantage is their low thermal conductivity which is compensated to an extent with the nano-enhanced PCMs (NEPCMs). In this study, numerical simulations are carried out to compare the natural convection phenomena and thermal response of PV-NEPCM with simple PV-PCM for various tilt angles. CuO nanoparticles with a 4% volume concentration are selected for NEPCM. The thermal performance of PV-NEPCM at inclinations of 0°, 15°, 30°, and 45\(^\circ\) are compared with a simple PV-PCM system. The average temperature of PV, liquid fraction and thermal energy stored in PCM, the PV efficiency are compared for PV-PCM and PV-NEPCM systems. Results show that the loading of nanoparticles increases the conduction heat transfer inside PCM. It has also been shown that at lower inclinations, the use of NEPCM is more effective due to the dominance of conduction heat transfer. At higher tilt angles, natural convection plays a significant role in the heat transfer mechanism inside PCM. By using NEPCM, the maximum decrease in PV temperature of 1.11\(℃\) and maximum improvement in the liquid fraction (7.6%) are achieved when \({\theta }=0^\circ\) compared to simple PCM. Enhancement of thermal energy stored in PCM increases slightly upon adding nanoparticles, and the highest improvement is obtained for \({\theta }=0^\circ .\) Maximum enhancement of PV efficiency is found to be 1.6% for \({\theta }=0^\circ\) inclination on adding nanoparticles at a fraction of 4 vol.%. Keywords: PV, nano-enhanced PCM, nanoparticles, natural convection, liquid fraction.
NF-κB/ABCA1 Pathway Aggravates ox-LDL-Induced Cell Pyroptosis by Activation of NLRP3 Inflammasomes in THP-1-Derived Macrophages
Authors: Li Jiashan , Liu Jiaru , Yu Ying , Liu Yuee , Guan Xiuru 
Published: August 2021

Abstract
There is now overwhelming experimental and clinical evidence that atherosclerosis is a chronic inflammatory disease and characterized by lipid deposition in blood vessels. Pyroptosis, an inflammatory form of cell death by certain inflammasomes, has been shown to be associated with the development of AS in recent years. However, the relationship between lipid deposition in foam cells and cell pyroptosis has not been clarified. Here, we demonstrate that with increasing ox-LDL concentration, the expression of pyroptosis associated protein GSDMD, NLRP3 inflammasome gradually increased, intracellular LDH and mature IL-1β release increased, and the proportion of double positive cells with Hoechst/PI staining increased. Interestingly, the expression of NF-κB signal activation marker protein p-NF-κB and p-IκB increased with the increase of ox-LDL concentration. Ox-LDL-induced pyroptosis can be abolished by NF-κB phosphorylation inhibitor, BAY11-7082. Additionally, BAY11-7082 could also significantly up-regulate the protein expression of ABCA1 and eliminate the inhibitory effect of ox-LDL on the expression of ABCA1.Moreover, siABCA1 was transfected into THP-1-derived macrophages under ox-LDL treatment. Compared with the control group, the expression of GSDMD and NLRP3 inflammasome, the release of mature IL-1β and LDH increased, and the proportion of Hoechst/PI staining double-positive cells increased with blocked cholesterol efflux. Finally, cells treated with VX-765, a pyroptosis inhibitor, showed increased cholesterol efflux and cell foaming in THP-1-derived macrophages,which suggest that cell pyroptosis may be a "double-edged sword" in the development of AS. In conclusion,our findings demonstrate for the first time that the NF-κB/ABCA1 pathway is involved in ox-LDL induced pyroptosis by cholesterol efflux blocked activation of NLRP3 inflammasomes in THP-1-derived macrophages, providing a new therapeutic avenue for the prevention and treatment of AS.
Implementation of Project Management Concept for Conversion into a Smart City: A Case Study on Agartala
Authors: Paul Swarup 
Published: August 2021

Abstract
Recently the smart city concept has become a burning topic in India. The government of India has already selected more than hundred cities to be converted into smart cities. Agartala, the capital of Tripura, is one of such selected cities. There are numerous applications of engineering aspects in the course of conversion of a city into a smart city. Project Management is one such area which has tremendous application in smart city development. But extensive literature reviews show only the concept, various constituents, and effects of a smart city on its citizens. No systematic procedure of implementation of different activities with a view to converting a city into a smart city using the concept of Project Management from nascent stage has been found in literature. Application of Project Management can help a lot the competent authority to get a clear idea on different components of smart city project. The present work highlights the application of Project Management on smart city development. Agartala city has been considered as a case study for this present work due to its typical geographical location as well as different activities it requires to start with. The degree of importance of different activities in the network diagram of the project has been decided by applying multi criteria decision making tools. Thus, this present work finally determines the total project completion time together with critical activities of the project. This work can give rise to a general idea in the competent authorities dealing with other cities also.