bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fixed point theorems in modular G-metric spaces
Authors: Okeke Godwin Amechi , Francis Daniel , de la Sen Manuel , Abbas Mujahid 
Published: October 2021

AbstractWe prove the existence and uniqueness of fixed points of some generalized contractible operators defined on modularG-metric spaces and also prove the modularG-continuity of such operators. Furthermore, we prove that some generalized weakly compatible contractive operators in modularG-metric spaces have a unique fixed point. Our results extend, generalize, complement and include several known results as special cases.
Operational matrices based on the shifted fifth-kind Chebyshev polynomials for solving nonlinear variable order integro-differential equations
Authors: Jafari H. , Nemati S. , Ganji R. M. 
Published: October 2021

AbstractIn this research, we study a general class of variable order integro-differential equations (VO-IDEs). We propose a numerical scheme based on the shifted fifth-kind Chebyshev polynomials (SFKCPs). First, in this scheme, we expand the unknown function and its derivatives in terms of the SFKCPs. To carry out the proposed scheme, we calculate the operational matrices depending on the SFKCPs to find an approximate solution of the original problem. These matrices, together with the collocation points, are used to transform the original problem to form a system of linear or nonlinear algebraic equations. We discuss the convergence of the method and then give an estimation of the error. We end by solving numerical tests, which show the high accuracy of our results.
An Ethnographic study of unhealthy alcohol use in a Danish Emergency Department
Authors: Sivertsen Ditte Maria , Becker Ulrik , Andersen Ove , Kirk Jeanette Wassar 
Published: October 2021

Abstract
Background
Emergency Departments (EDs) are important arenas for the detection of unhealthy substance use. Screening, Brief Intervention, and Referral to Treatment (SBIRT) for unhealthy alcohol use has been used in some ED settings with funding support from external sources. However, widespread sustained implementation is uncommon, and research aimed at understanding culture as a determinant for implementation is lacking. This study aims to explore cultural practices concerning the handling of patients with unhealthy alcohol use admitted to an ED.

Methods
An ethnographic study was conducted in an ED in the Capital Region of Denmark. The data consists of participant observations of Health Care Professionals (HCPs) and semi-structured interviews with nurses. Data was collected from July 2018 to February 2020. A cultural analysis was performed by using Qualitative Content Analysis as an analytic tool.

Results
150 h of observation and 11 interviews were conducted. Three themes emerged from the analysis: (1) Setting the scene describes how subthemes “flow,” “risky environment,” and “physical spaces and artefacts” are a part of the contextual environment of an ED, and their implications for patients with unhealthy alcohol use, such as placement in certain rooms; (2) The encounter presents how patients’ and HCPs’ encounters unfold in everyday practice. Subtheme “Professional differences” showcases how nurses and doctors address patients’ alcohol habits differently, and how they do not necessarily act on the information provided, due to several factors. These factors are shown in remaining sub-themes “gut-feeling vs. clinical parameters,” “ethical reasoning,” and “from compliance to zero-tolerance”; and (3) Collective repertoires shows how language shapes the perception of patients with unhealthy alcohol use, which may cause stigma and stereotyping. Subthemes are “occupiers” and “alcoholic or party animal?”.

Conclusions
Unhealthy alcohol use in the ED is entangled in complex cultural networks. Patients with severe and easily recognizable unhealthy alcohol use—characterized by an alcohol diagnosis in the electronic medical record, intoxication, or unwanted behavior—shape the general approach and attitude to unhealthy alcohol use. Consequently, from a prevention perspective, this means that patients with less apparent unhealthy alcohol use tend to be overlooked or neglected, which calls for a systematic screening approach.
Intermediate field directions recorded in Pliocene basalts in Styria (Austria): evidence for cryptochron C2r.2r-1
Authors: Schnepp Elisabeth , Arneitz Patrick , Ganerød Morgan , Scholger Robert , Fritz Ingomar , Egli Ramon , Leonhardt Roman 
Published: October 2021

AbstractPliocene volcanic rocks from south-east Austria were paleomagnetically investigated. Samples were taken from 28 sites located on eight different volcanoes. Rock magnetic investigations revealed that magnetic carriers are Ti-rich or Ti-poor titanomagnetites with mainly pseudo-single-domain characteristics. Characteristic remanent magnetization directions were obtained from alternating field as well as from thermal demagnetization. Four localities give reversed directions agreeing with the expected direction from secular variation. Another four localities of the Klöch–Königsberg volcanic complex (3) and the Neuhaus volcano (1) have reversed directions with shallow inclinations and declinations of about 240° while the locality Steinberg yields a positive inclination of about 30° and 200° declination. These aberrant directions cannot be explained by local or regional tectonic movements. All virtual geomagnetic pole positions are located on the southern hemisphere. Four virtual geomagnetic poles lie close to the geographic pole, while all others are concentrated in a narrow longitude sector offshore South America (310°–355°) with low virtual geomagnetic pole latitudes ranging from − 15° to − 70°. The hypothesis that a transitional geomagnetic field configuration was recorded during the short volcanic activity of these five localities is supported by 9 paleointensity results and39Ar/40Ar dating. Virtual geomagnetic dipole moments range from 1.1 to 2.9·1022Am2for sites with low VGP latitudes below about 60° and from 3.0 to 9.3·1022Am2for sites with higher virtual geomagnetic pole latitudes. The new39Ar/40Ar ages of 2.51 ± 0.27 Ma for Klöch and 2.39 ± 0.03 Ma for Steinberg allow for the correlation of the Styrian transitional directions with cryptochron C2r.2r-1 of the geomagnetic polarity time scale.Graphic abstract
Solar radiation effects on leaf nitrogen and phosphorus stoichiometry of Chinese fir across subtropical China
Authors: Tong Ran , Cao Yini , Zhu Zhihong , Lou Chenyang , Zhou Benzhi , Wu Tonggui 
Published: October 2021

Abstract
Background
Solar radiation (SR) plays critical roles in plant physiological processes and ecosystems functions. However, the exploration of SR influences on the biogeochemical cycles of forest ecosystems is still in a slow progress, and has important implications for the understanding of plant adaption strategy under future environmental changes. Herein, this research was aimed to explore the influences of SR on plant nutrient characteristics, and provided theoretical basis for introducing SR into the establishment of biochemical models of forest ecosystems in the future researches.

Methods
We measured leaf nitrogen (N) and phosphorus (P) stoichiometry in 19 Chinese fir plantations across subtropical China by a field investigation. The direct and indirect effects of SR, including global radiation (Global R), direct radiation (Direct R) and diffuse radiation (Diffuse R) on the leaf N and P stoichiometry were investigated.

Results
The linear regression analysis showed that leaf N concentration had no association with SR, while leaf P concentration and N:P ratio were negatively and positively related to SR, respectively. Partial least squares path model (PLS-PM) demonstrated that SR (e.g. Direct R and Diffuse R), as a latent variable, exhibited direct correlations with leaf N and P stoichiometry as well as the indirect correlation mediated by soil P content. The direct associations (path coefficient = − 0.518) were markedly greater than indirect associations (path coefficient = − 0.087). The covariance-based structural equation modeling (CB-SEM) indicated that SR had direct effects on leaf P concentration (path coefficient = − 0.481), and weak effects on leaf N concentration. The high SR level elevated two temperature indexes (mean annual temperature, MAT; ≥ 10 °C annual accumulated temperature, ≥ 10 °C AAT) and one hydrological index (mean annual evapotranspiration, MAE), but lowered the soil P content. MAT, MAE and soil P content could affect the leaf P concentration, which cause the indirect effect of SR on leaf P concentration (path coefficient = 0.004). Soil N content had positive effect on the leaf N concentration, which was positively and negatively regulated by MAP and ≥ 10 °C AAT, respectively.

Conclusions
These results confirmed that SR had negatively direct and indirect impacts on plant nutrient status of Chinese fir based on a regional investigation, and the direct associations were greater than the indirect associations. Such findings shed light on the guideline of taking SR into account for the establishment of global biogeochemical models of forest ecosystems in the future studies.
Can consumers’ gamified, personalized, and engaging experiences with VR fashion apps increase in-app purchase intention by fulfilling needs?
Authors: Lau Oiyan , Ki Chung-Wha 
Published: October 2021

AbstractWhile the development of virtual reality (VR) apps is trending among fashion retailers to cope with the COVID-19 pandemic and promote consumers’ online shopping, less is understood about whether and the way these new VR apps increase consumers’ in-app purchase. This study was designed to address this issue by applying self-determination theory within the context of Taobao Life, a 3D avatar-based and game-featured virtual world on the Taobao app. Specifically, we investigated (1) whether the extent to which a VR fashion app provides consumers with a sense of gamified experience (H1: challenge, and H2: achievement), personalized experience (H3: avatar customization, and H4: avatar identification), and engaging experience (H5: social presence, and H6: social support) fulfills their competence, autonomy, and relatedness needs; (2) whether these intrinsic needs fulfill determine positive consumer behavioral intentions (H7: intention to continue to use VR apps, and H8: intention to make in-app purchase), and (3) whether the intention to continue to use VR apps leads to a positive in-app purchase intention (H9). We tested the above empirically by conducting an online survey via Dynata, and the dataset of 251 responses was analyzed using structural equation modeling. The findings of our research provide theoretical and practical implications that can be applied in the fashion retail business.
Housing arrangement and vegetation factors associated with single-family home survival in the 2018 Camp Fire, California
Authors: Knapp Eric E. , Valachovic Yana S. , Quarles Stephen L. , Johnson Nels G. 
Published: October 2021

AbstractBackgroundThe 2018 Camp Fire, which destroyed 18,804 structures in northern California, including most of the town of Paradise, provided an opportunity to investigate housing arrangement and vegetation-related factors associated with home loss and determine whether California’s 2008 adoption of exterior building codes for homes located in the wildland-urban-interface (WUI) improved survival. We randomly sampled single-family homes constructed: before 1997, 1997 to 2007, and 2008 to 2018, the latter two time periods being before and after changes to the building code. We then quantified the nearby pre-fire overstory canopy cover and the distance to the nearest destroyed home and structure from aerial imagery. Using post-fire photographs, we also assessed fire damage and assigned a cause for damaged but not destroyed homes.ResultsHomes built prior to 1997 fared poorly, with only 11.5% surviving, compared with 38.5% survival for homes built in 1997 and after. The difference in survival percentage for homes built immediately before and after the adoption of Chapter 7A in the California Building Code (37% and 44%, respectively) was not statistically significant. Distance to nearest destroyed structure, number of structures destroyed within 100 m, and pre-fire overstory canopy cover within 100 m of the home were the strongest predictors of survival, but significant interactions with the construction time period suggested that factors contributing to survival differed for homes of different ages. Homes >18 m from a destroyed structure and in areas with pre-fire overstory canopy cover within 30–100 m of the home of <53% survived at a substantially higher rate than homes in closer proximity to a destroyed structure or in areas with higher pre-fire overstory canopy cover. Most fire damage to surviving homes appeared to result from radiant heat from nearby burning structures or flame impingement from the ignition of near-home combustible materials.ConclusionsStrong associations between both distance to nearest destroyed structure and vegetation within 100 m and home survival in the Camp Fire indicate building and vegetation modifications are possible that would substantially improve outcomes. Among those include improvements to windows and siding in closest proximity to neighboring structures, treatment of wildland fuels, and eliminating near-home combustibles, especially in areas closest to the home (0–1.5 m).
Preparation and evaluation of polymeric beads composed of Chitosan–Gellan Gum–Gum Ghatti/-Gum Karaya polyelectrolyte complexes as polymeric carrier for enteric sustained delivery of Diclofenac sodium
Authors: Verma Anurag , Kumar Pradeep , Rastogi Vaibhav , Mittal Piyush 
Published: October 2021

Abstract
Background
An enteric coating is a multistep technique that involves deposition of a polymeric barrier over uncoated orally administered tablets to prevent them from dissolving or disintegrating in the stomach. However, as soon as the coating dissolves in the alkaline environment of intestine, the whole of the drug come in direct contact with gastric mucosa leading to irritation to distal parts of the gastrointestinal tract (GIT). Considering the above facts, there is clear need to develop a simple and effective enteric release formulation for gastric irritant drugs like Diclofenac sodium (DS). The goal of this study was to create enteric release polymeric polyelectrolyte complex (PEC) beads made up of cationic Chitosan (CH) and anionic Gellan Gum (GG) for sustained DS delivery to the intestine. The beads were prepared by extruding a solution of GG and Gum Ghatti (GT) or GG and Gum Karaya (GK) bearing DS into CH solution in 1% w/v acetic acid, with the help of a syringe fitted with a 18 gauge hypodermic needle.

Results
Instantly created spherical beads were dried in a hot air oven 60 °C overnight. In 0.1 M HCl and 6.8 pH phosphate buffer, the dried beads were tested for drug entrapment in the beads, in vitro swelling of beads and in vitro drug release studies from the beads. The % drug entrapment efficiencies (% DEE) of these PEC beads ranged from 59.54 ± 2.09 to 81.03 ± 4.22%. In 0.1 M HCl, the PEC beads swelled the least in vitro, but expanded significantly in phosphate buffer (pH 6.8). The in vitro release of Diclofenac sodium from different PEC beads in 0.1 M HCl was found to be less than 7.5 percent, whereas the release was sustained for 6 h in phosphate buffer (pH 6.8).

Conclusions
From the experimental data, it may be concluded that these PEC beads can be useful as potential multiple-unit enteric release polymeric carrier systems for sustained delivery of gastric irritant drugs like Diclofenac sodium.
Peptide-based enteral formula vs a whole protein enteral formula after major intestinal surgeries in children
Authors: Mostafa Mohamed Saber , Gamal Yasmin , Soliman Mohamed H. 
Published: October 2021

Abstract
Background
Malnutrition is a common finding after major abdominal surgeries especially after prolonged period of fasting in children. Enteral feeding is the commonest support way postoperatively for stimulating gut hormones, modulating immunity, and maintaining the barrier function of the intestinal mucosa.
Our aim was to compare the results and outcome regarding tolerance, nutritional status, and hospital stay following a postoperative diet of peptide-based enteral formula against a whole protein enteral formula after major intestinal surgeries in pediatric patients who had resection and re-anastomosis after intussusception.

Results
This is a prospective cohort study on two groups of patients with a total of 30 patients during the period between January 2019 and June 2020.
All patients in both groups underwent major intestinal surgeries (resection and re-anastomosis after intussusception). The first group received postoperative whole protein formula exclusively on the 3rd postoperative day while the other group received peptide-based formula exclusively on the same day.
Postoperative mean serum albumin and pre-albumin levels were significantly higher in peptide-based formula group compared to those who had protein-based formula as their initial feeds (P value < 0.05). The average hospital stay was also significantly shorter in the peptide group (P value < 0.05). Peptide formula was easily tolerated than protein formula in postoperative children who had major intestinal surgeries.

Conclusion
Peptide-based enteral formulas are better tolerated and more useful as regards nutritional status than whole-protein formulas in post-operative course of pediatric patients regarding clinical outcome and better economically with shorter hospital stay.
Ibrutinib Plus Rituximab Versus Placebo Plus Rituximab for Waldenström's Macroglobulinemia: Final Analysis From the Randomized Phase III iNNOVATE Study
Authors: Buske Christian , Tedeschi Alessandra , Trotman Judith , García-Sanz Ramón , MacDonald David , Leblond Veronique , Mahe Beatrice , Herbaux Charles , Matous Jeffrey V. , Tam Constantine S. , Heffner Leonard T. , Varettoni Marzia , Palomba M. Lia , Shustik Chaim , Kastritis Efstathios , Treon Steven P. , Ping Jerry , Hauns Bernhard , Arango-Hisijara Israel , Dimopoulos Meletios A. 
Published: October 2021

PURPOSE The double-blind, randomized, placebo-controlled phase III iNNOVATE study showed sustained efficacy of ibrutinib-rituximab in Waldenström's macroglobulinemia (WM). Here, we present the final analysis from iNNOVATE. METHODS Patients had confirmed symptomatic WM, either previously untreated or previously treated; patients with prior rituximab had at least a minor response to their last rituximab-based regimen. Patients were randomly assigned to once-daily ibrutinib 420 mg plus rituximab or placebo plus rituximab (n = 75 per arm). The primary end point was progression-free survival (PFS). Secondary end points included response rate, time to next treatment, hemoglobin improvement, overall survival, and safety. RESULTS With a median follow-up of 50 (range, 0.5-63) months, median (95% CI) PFS was not reached (57.7 months to not evaluable) with ibrutinib-rituximab versus 20.3 months (13.0 to 27.6) with placebo-rituximab (hazard ratio, 0.250; P < .0001). PFS benefit was regardless of prior treatment status, MYD88 and CXCR4 mutation status, or key patient characteristics. Higher response rates (partial response or better) were observed with ibrutinib-rituximab (76% v 31% with placebo-rituximab; P < .0001) and were sustained over time. Median time to next treatment was not reached with ibrutinib-rituximab versus 18 months with placebo-rituximab. More patients receiving ibrutinib-rituximab versus placebo-rituximab had sustained hemoglobin improvement (77% v 43%; P < .0001). Median overall survival was not reached in either arm. Ibrutinib-rituximab maintained a manageable safety profile; the prevalence of grade ≥ 3 adverse events of clinical interest generally decreased over time. CONCLUSION In the final analysis of iNNOVATE with a median follow-up of 50 months, ibrutinib-rituximab showed ongoing superiority across clinical outcomes in patients with WM regardless of MYD88 or CXCR4 mutation status, prior treatment, and key patient characteristics.
Modelling sentiments based on objectivity and subjectivity with self-attention mechanisms
Authors: Ng Hu , Chia Glenn Jun Weng , Yap Timothy Tzen Vun , Goh Vik Tor 
Published: October 2021

Background: The proliferation of digital commerce has allowed merchants to reach out to a wider customer base, prompting a study of customer reviews to gauge service and product quality through sentiment analysis. Sentiment analysis can be enhanced through subjectivity and objectivity classification with attention mechanisms. Methods: This research includes input corpora of contrasting levels of subjectivity and objectivity from different databases to perform sentiment analysis on user reviews, incorporating attention mechanisms at the aspect level. Three large corpora are chosen as the subjectivity and objectivity datasets, the Shopee user review dataset (ShopeeRD) for subjectivity, together with the Wikipedia English dataset (Wiki-en) and Internet Movie Database (IMDb) for objectivity. Word embeddings are created using Word2Vec with Skip-Gram. Then, a bidirectional LSTM with an attention layer (LSTM-ATT) imposed on word vectors. The performance of the model is evaluated and benchmarked against classification models of Logistics Regression (LR) and Linear SVC (L-SVC). Three models are trained with subjectivity (70% of ShopeeRD) and the objectivity (Wiki-en) embeddings, with ten-fold cross-validation. Next, the three models are evaluated against two datasets (IMDb and 20% of ShopeeRD). The experiments are based on benchmark comparisons, embedding comparison and model comparison with 70-10-20 train-validation-test splits. Data augmentation using AUG-BERT is performed and selected models incorporating AUG-BERT, are compared. Results: L-SVC scored the highest accuracy with 56.9% for objective embeddings (Wiki-en) while the LSTM-ATT scored 69.0% on subjective embeddings (ShopeeRD). Improved performances were observed with data augmentation using AUG-BERT, where the LSTM-ATT+AUG-BERT model scored the highest accuracy at 60.0% for objective embeddings and 70.0% for subjective embeddings, compared to 57% (objective) and 69% (subjective) for L-SVC+AUG-BERT, and 56% (objective) and 68% (subjective) for L-SVC. Conclusions: Utilizing attention layers with subjectivity and objectivity notions has shown improvement to the accuracy of sentiment analysis models.