bluuebunny/crossref_metadata_2025_split huggingface dataset:
A numerical study of long-term multiwavelength blazar variability
Authors: Polkas M , Petropoulou M , Vasilopoulos G , Mastichiadis A , Urry C M , Coppi P , Bailyn C 
Published: June 2021

ABSTRACT
Decade-long monitoring of blazars at optical and infrared (OIR) wavelengths with the Small and Moderate Aperture Research Telescope System (SMARTS) in Chile and in γ-rays with the Fermi -Large Area Telescope (LAT) has enabled the systematic study of their multiwavelength long-term variability. In this work, we investigate, from a theoretical perspective, the long-term variability properties of blazar emission by introducing an observationally motivated time-dependence to four main parameters of the one-zone leptonic model: injection luminosity of relativistic electrons, strength of magnetic field, Doppler factor, and external photon field luminosity. For the first time, we use both the probability density function and the power spectral density of the 10-yr-long Fermi-LAT light curves to create variation patterns for the model parameters. Using as test beds two bright blazars from the SMARTS sample (PKS 2155−304 and 3C 273), we compute 10-yr-long OIR, X-ray, and γ-ray model light curves for different varying parameters. We compare the findings of our theoretical investigation with multiwavelength observations using various measures of variability. While no single-varying parameter simulation can explain all multiwavelength variability properties, changes in the electron luminosity and external radiation field in PKS 2155−304 and 3C 273, respectively, can account for most of them. Our results motivate future time-dependent studies with coupling between two or more physical parameters to describe the multiwavelength long-term blazar variability.
The GALAH survey and symbiotic stars – I. Discovery and follow-up of 33 candidate accreting-only systems
Authors: Munari U , Traven G , Masetti N , Valisa P , Righetti G-L , Hambsch F-J , Frigo A , Čotar K , De Silva G M , Freeman K C , Lewis G F , Martell S L , Sharma S , Simpson J D , Ting Y-S , Wittenmyer R A , Zucker D B 
Published: June 2021

ABSTRACT
We have identified a first group of 33 new candidates for symbiotic stars (SySt) of the accreting-only variety among the 600 255 stars so far observed by the GALactic Archaeology with HERMES (GALAH) high-resolution spectroscopic survey of the Southern hemisphere, more than doubling the number of those previously known. GALAH aims to high latitudes and this offers the possibility to sound the Galaxy for new SySt away from the usual plane and bulge hunting regions. In this paper, we focus on SySt of the M spectral type, showing an Hα emission with a peak in excess of 0.5 above the adjacent continuum level, and not affected by coherent radial pulsations. These constraints will be relaxed in future studies. The 33 new candidate SySt were subjected to an array of follow-up confirmatory observations [X-ray/ultraviolet (UV) observations with the Swift satellite, search for optical flickering, presence of a near-UV upturn in ground-based photometric and spectroscopic data, radial velocity changes suggestive of orbital motion, and variability of the emission-line profiles]. According to Gaia Early Data Release 3 (EDR3) parallaxes, the candidate new SySt are located at the tip of the giant branch, sharing the same distribution in M(Ks) of the well-established SySt. The accretion luminosities of the candidate new SySt are in the range 1–10 L⊙, corresponding to mass accretion rates of 0.1–1 × 10−9 M⊙ yr−1 for white dwarfs of 1 M⊙. The M giant of one of them presents a large lithium overabundance.
WD mass and orbital period relation of sdB + He WD binaries
Authors: Zhang Yangyang , Chen Hai-Liang , Xiong Heran , Chen Xuefei , Han Zhanwen 
Published: June 2021

ABSTRACT
Most subdwarf B (sdB) + Helium white dwarf (He WD) binaries are believed to be formed from a particular channel. In this channel, the He WDs are produced first from red giants (RGs) with degenerate cores via stable mass transfer and sdB stars are produced from RGs with degenerate cores via common-envelope (CE) ejection. They are important for the studies of CE evolution, binary evolution, and binary population synthesis. However, the relation between WD mass and orbital period of sdB + He WD binaries has not been specifically studied. In this paper, we first use a semi-analytic method to follow their formation and find a WD mass and orbital period relation. Then we use a detailed stellar evolution code to model their formation from main-sequence binaries. We find a similar relation between the WD mass and orbital period, which is in broad agreement with observations. For most sdB + He WD systems, if the WD mass (orbital period) can be determined, the orbital period (WD mass) can be inferred with this relation and then the inclination angle can be constrained with the binary mass function. In addition, we can also use this relation to constrain the CE ejection efficiency and find that a relative large CE ejection efficiency is favoured. If both the WD and sdB star masses can be determined, the critical mass ratios of dynamically unstable mass transfer for RG binaries can also be constrained.
The unique bryophyte-specific repeat-containing protein SHORT-LEAF regulates gametophore development in moss
Authors: Mohanasundaram Boominathan , Bhide Amey J. , Palit Shirsa , Chaturvedi Gargi , Lingwan Maneesh , Masakapalli Shyam Kumar , Banerjee Anjan K. 
Published: June 2021

AbstractConvergent evolution of shoot development across plant lineages has prompted numerous comparative genetic studies. Though functional conservation of gene networks governing flowering plant shoot development has been explored in bryophyte gametophore development, the role of bryophyte-specific genes remains unknown. Previously, we have reported Tnt1 insertional mutants of moss defective in gametophore development. Here, we report a mutant (short-leaf; shlf) having two-fold shorter leaves, reduced apical dominance, and low plasmodesmata frequency. UHPLC-MS/MS-based auxin quantification and analysis of soybean (Glycine max) auxin-responsive promoter (GH3:GUS) lines exhibited a striking differential auxin distribution pattern in the mutant gametophore. Whole-genome sequencing and functional characterization of candidate genes revealed that a novel bryophyte-specific gene (SHORT-LEAF; SHLF) is responsible for the shlf phenotype. SHLF represents a unique family of near-perfect tandem direct repeat (TDR)-containing proteins conserved only among mosses and liverworts, as evident from our phylogenetic analysis. Cross-complementation with a Marchantia homolog partially recovered the shlf phenotype, indicating possible functional specialization. The distinctive structure (longest known TDRs), absence of any known conserved domain, localization in the endoplasmic reticulum, and proteolytic cleavage pattern of SHLF imply its function in bryophyte-specific cellular mechanisms. This makes SHLF a potential candidate to study gametophore development and evolutionary adaptations of early land plants.
Opioid Crisis Effects on Municipal Finance
Authors: Cornaggia Kimberly , Hund John , Nguyen Giang , Ye Zihan 
Published: June 2021

Abstract
We investigate the effects of opioid abuse on municipal finance. We employ instrumental variables, border discontinuity difference-in-differences regressions, and coarsened exact matching to identify consistent causal effects, while controlling for variation in economic conditions and demographics. Opioid abuse lowers credit ratings, increases new offer yields, and reduces bond issuance. Reversal of these effects following effective antiopioid legislation further supports causality. Differential effects due to investor heterogeneity suggest that opioid abuse affects municipal finance through a capital supply channel. Overall, we conclude that local opioid abuse impedes municipalities’ access to capital and thus hurts their ability to provide public services and infrastructure.
ESTIMATION OF DIAGNOSTIC REFERENCE LEVELS AND ACHIEVABLE DOSES FOR PEDIATRIC PATIENTS IN COMMON COMPUTED TOMOGRAPHY EXAMINATIONS: A MULTI-CENTER STUDY
Authors: Zamani Hamed , Kavousi Nasim , Masjedi Hamidreza , Omidi Reza , Rahbar Shiva , Perota Ghazale , Razavi Elham , Zare Mohammad Hosein , Abedi-Firouzjah Razzagh 
Published: June 2021

Abstract
This study was conducted to determine first local diagnostic reference levels (DRLs) and achievable doses (ADs) for pediatric patients during the most common computed tomography (CT) procedures in Yazd province. The DRL was obtained based on volume CT dose index (CTDIvol) and dose length product (DLP) for four various age groups of children. Data were collected from the most commonly performed pediatric CT scans, including abdomen–pelvis, chest, brain and sinus examinations, at six high-loaded institutes. The patients’ data (766 no.) in terms of CTDIvol and DLP were obtained from four age groups: ≤1-, 1–5-, 5–10- and 10–15-y-old. The 75th percentiles of CTDIvol and DLP were considered as DRL values and the 50th percentiles were described as ADs for those parameters. Consequently, the acquired DRLs were compared with other national and international published values. The DRLs in terms of CTDIvol for abdomen–pelvis, chest, brain and sinus examinations were 3, 8, 9 and 10 mGy; 4, 5, 5 and 5 mGy; 25, 28, 29 and 38 mGy; and 23, 24, 26 and 27 mGy for four different age groups of ≤1-, 1–5-, 5–10- and 10–15-y-old, respectively. The DRL values in terms of DLP were 75, 302, 321 and 342 mGy.cm; 109, 112, 135 and 170 mGy.cm, 352, 355, 360 and 481 mGy.cm; and 206, 211, 228 and 245 mGy.cm, respectively, for the mentioned age groups. In this study, the DRL and AD values in the brain examination were greater among the other studied regions. The DRL plays a critical role in the optimization of radiation doses delivered to patients and in improving their protection. This study provides the local DRLs and ADs for the most common pediatric CT scanning in Yazd province to create optimum situation for the clinical practice.
Patient-Reported Outcomes After Lateral Process Talus Fracture
Authors: Ross Hunter , Marchand Lucas , Cardon Jeffery , Beals Timothy , Barg Alex , Nickisch Florian , Haller Justin M. 
Published: June 2021

Objectives:
To evaluate functional outcome after lateral process talus fracture using patient-reported instruments and identify injury characteristics that portend a worse prognosis.

Design:
Retrospective case series.

Setting:
Level 1 academic trauma center.

Patients/Participants:
Fifty-three patients with isolated lateral process talus fracture and 12 months of minimum follow-up.

Main Outcome Measurements:
Patient-Reported Outcomes Measurement Information System (PROMIS) physical function (PF) and Foot and Ankle Ability Measure (FAAM).

Results:
Mean patient age was 33 years (range, 17–62 years), and mean follow-up was 6.5 years (range, 1–12 years). Twenty-one patients were initially treated nonoperatively and 14 of these patients (67%) failed nonoperative management. Patients who failed nonoperative treatment more commonly had a displaced fracture (12 patients) (P = 0.009). Thirty-two patients had displaced fracture and were treated with early operative fixation. For the entire cohort, final PROMIS PF was 55 (SD −8.3), FAAM Activities of Daily Living (ADL) was 89 (SD −14), and FAAM sport was 77 (SD −20). The patients treated with operative fixation had significantly larger fracture fragments (2050 vs. 1066 mm3, P = 0.017). There was no difference in final outcome between operative and nonoperative patients for PROMIS PF (P = 0.84), FAAM ADL (P = 0.95), or FAAM sport (P = 0.94). There were significantly more subtalar fusions in the nonoperative group (4 patients) as compared to the operative group (one patient) (P = 0.05).

Conclusions:
Most patients with lateral process talus fracture achieve excellent outcome as measured by the PROMIS PF and FAAM at medium-term follow-up. Displaced fractures are likely best managed with early surgical treatment. Patients treated with early surgery have significantly fewer subtalar fusions as compared to patients with nonoperative treatment.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Assessment of Lateral Rotation Percentage and Rotational Deformity of the Elbow in Type 3 Supracondylar Humerus Fractures: A Biomechanical Study
Authors: Berdis Galen , Hooper Matthew , Talwalkar Vishwas , Walker Janet , Muchow Ryan , Riley Scott , Iwinski Henry J. , Prusick Vincent 
Published: June 2021

Background:
Supracondylar humerus (SCH) fractures are the most common elbow fractures in children. Historically, displaced (Gartland type 3) SCH fractures have been treated with closed reduction and percutaneous pinning. Fluoroscopic imaging is used intraoperatively in order to assess adequate reduction of the fracture fragments before pinning. On lateral fluoroscopic and radiographic images, a lateral rotation percentage (LRP) can be estimated in order to assess rotational deformity. The purpose of this study was to determine the true rotational deformity of distal humerus fracture fragments in SCH fractures based upon the LRP using a clinically relevant laterally based pinning technique.

Methods:
In this study, a sawbones model was used to examine the correlation between calculated LRP and the true degree of rotational deformity with 3 of the most common extension-type SCH fracture types (low transverse, high transverse, and lateral oblique). Because fracture stability was not the focus of this study, a single pin was used to hold the construct and allow for fragment rotation along a fixed axis. In this study, 2 of the authors independently measured rotational deformity and compared this with LRP on fluoroscopic lateral imaging of a sawbones model at 0 to 45 degrees of rotational deformity.

Results:
The LRP of all 3 patterns demonstrated a near linear increase from 0 to 45 degrees with maximum LRP measured at 45 degrees for each of the 3 patterns. Univariate linear regression demonstrated an increase in LRP for the low transverse pattern of 2.02% for every degree of rotation deformity (R
2=0.97), 2.29% for the lateral oblique pattern (R
2=0.986), and 1.17% for the high transverse pattern (R
2=0.971). Maximum LRP was measured at 45 degrees for all 3 patterns with a mean of 53.5% for the high transverse pattern, 93.5% for the low transverse pattern, and 111.2% for the lateral oblique pattern. A higher LRP was measured with increasing degrees of rotational displacement in the low transverse and lateral oblique patterns for all degrees of rotational deformity compared to the high transverse pattern.

Conclusion:
There is a near linear correlation between the degree of malrotation and the LRP with more superior metaphyseal fracture patterns demonstrating a lower LRP than inferior fracture patterns.

Clinical Relevance:
Using our data one can estimate the degree of malrotation based on the LRP on radiographs in the clinical setting.

Level of Evidence:
Not applicable (basic-science article).
Oncological and Functional Outcomes in Joint-sparing Resections of the Proximal Femur for Malignant Primary Bone Tumors
Authors: Ramkumar Dipak B. , Kelly Sean P. , Ramkumar Niveditta , Ercolano Lisa B. , Lozano-Calderon Santiago , Gebhardt Mark C. , Anderson Megan E. 
Published: June 2021

Background
Joint-sparing resections (JSR) of the proximal femur allow for preservation of the proximal femoral growth plate and native hip joint, but whether this offers fewer complications or better function and longevity of the reconstruction remains unknown. In this study, we compared the functional outcomes of pediatric patients with bone sarcomas undergoing JSR of the proximal femur with intercalary allograft (ICA) reconstruction to those undergoing proximal femoral resections (PFR) with allograft-prosthetic composite (APC) reconstructions.

Methods:
We retrospectively reviewed all patients undergoing JSR with ICA reconstruction and PFR with APC reconstructions between 1995 and 2013 at a tertiary pediatric referral center. Primary outcomes included major and minor complications and secondary outcomes included the need for a secondary procedure, presence of local or distant relapse, survival status, and the presence of pain and ambulatory status (limp, assistive device, highest level of function). We assessed differences in outcomes using the Fisher exact and Wilcoxon rank-sum tests.

Results:
Eight patients underwent a JSR and ICA reconstruction, while 7 patients underwent a PFR with APC reconstruction. Median patient follow-up was 60.4 months (interquartile range: 36.8 to 112.9) Patients undergoing JSR and ICA reconstruction were younger than patients undergoing PFR with APC reconstruction (7.7 vs. 11.7 y, P=0.043); however, we found no other statistically significant differences in patient demographics. There were no statistically significant differences in primary or secondary outcomes between the study groups; however, patients who underwent JSR with ICA had more major complications (62.5% vs. 42.9%, P=0.29) and a lower rate of minor complications (25% vs. 28.6%, P=0.22).

Conclusion:
Treatment of proximal femoral bone sarcomas in pediatric and adolescent patients remains a challenging enterprise. JSR with ICA reconstruction in the proximal femur, when feasible, may provide a similar function and risk of intermediate-term major and minor complications when compared with PFR with APC reconstruction. Further long-term studies are required to determine the impact of the native femoral head retention with respect to revision rates.

Level of Evidence:
Level III, retrospective comparative study.
Spinal Cord Medial Safe Zone for C2 Pedicle Instrumentation
Authors: Chiapparelli Erika , Bowen Edward , Okano Ichiro , Salzmann Stephan N. , Reisener Marie-Jacqueline , Shue Jennifer , Sama Andrew A. , Cammisa Frank P. , Girardi Federico P. , Hughes Alexander P. 
Published: June 2021

Study Design.
Retrospective observational study.

Objective.
The aim of this study was to investigate the spinal cord safety margins for C2 instrumentation.

Summary of Background Data.
Intraoperative spinal cord injury during C2 spine surgery is a rare, but potentially life-threatening complication. Preoperative planning for C2 instrumentation mainly focuses on C2 pedicle bony dimensions on CT and the vertebral artery location and few studies have evaluated C2 spinal cord safety margins.

Methods.
We measured two distances in C2 bilaterally: C2 pedicle to dura distance (P-D), defined as a transverse line that measured the shortest distance between the medial wall of the C2 pedicle and the dural sac, and C2 pedicle to spinal cord (P-SC), defined as a transverse line that measured the shortest distance between the medial wall of the C2 pedicle and spinal cord. We defined the distances >4 mm as safe for instrumentation.

Result.
A total of 146 patients (mean age 71.2, 50.7% female) were included. The average distances were 5.5 mm for C2 left PD, 5.9 mm for C2 right P-D, 10.1 mm for C2 left P-SC, and 10.6 mm for C2 right P-SC. Twenty-eight (21.4%) patients had C2 P-D distances <4 mm and of those two (7%) patients had distances <2 mm. There were more female patients with C2 P-D distances under 4 mm compared to males. No patient had C2 P-SC distances <4 mm.

Conclusion.
We demonstrated that around 20% of patients had C2 P-D distance <4 mm, but no patient had C2 P-SC distance <4 mm. Since a lateral misplacement can lead to a potentially fatal vertebral artery injury, medial screw trajectory is recommended for C2 pedicle instrumentation with consideration of these safety margins.

Level of Evidence: 3
Cardiovascular and renal burdens of metabolic associated fatty liver disease from serial US national surveys, 1999–2016
Authors: Zhang Hao-Jie , Wang Yu-Ying , Chen Chi , Lu Ying-Li , Wang Ning-Jian 
Published: June 2021

Abstract

Background:
Non-communicable chronic diseases have become the leading causes of disease burden worldwide. The trends and burden of “metabolic associated fatty liver disease” (MAFLD) are unknown. We aimed to investigate the cardiovascular and renal burdens in adults with MAFLD and non-alcoholic fatty liver disease (NAFLD).

Methods:
Nationally representative data were analyzed including data from 19,617 non-pregnant adults aged ≥20 years from the cross-sectional US National Health and Nutrition Examination Survey periods, 1999 to 2002, 2003 to 2006, 2007 to 2010, and 2011 to 2016. MAFLD was defined by the presence of hepatic steatosis plus general overweight/obesity, type 2 diabetes mellitus, or evidence of metabolic dysregulation.

Results:
The prevalence of MAFLD increased from 28.4% (95% confidence interval 26.3–30.6) in 1999 to 2002 to 35.8% (33.8–37.9) in 2011 to 2016. In 2011 to 2016, among adults with MAFLD, 49.0% (45.8–52.2) had hypertension, 57.8% (55.2–60.4) had dyslipidemia, 26.4% (23.9–28.9) had diabetes mellitus, 88.7% (87.0–80.1) had central obesity, and 18.5% (16.3–20.8) were current smokers. The 10-year cardiovascular risk ranged from 10.5% to 13.1%; 19.7% (17.6–21.9) had chronic kidney diseases (CKDs). Through the four periods, adults with MAFLD showed an increase in obesity; increase in treatment to lower blood pressure (BP), lipids, and hemoglobin A1c; and increase in goal achievements for BP and lipids but not in goal achievement for glycemic control in diabetes mellitus. Patients showed a decreasing 10-year cardiovascular risk over time but no change in the prevalence of CKDs, myocardial infarction, or stroke. Generally, although participants with NAFLD and those with MAFLD had a comparable prevalence of cardiovascular disease and CKD, the prevalence of MAFLD was significantly higher than that of NAFLD.

Conclusions:
From 1999 to 2016, cardiovascular and renal risks and diseases have become highly prevalent in adults with MAFLD. The absolute cardiorenal burden may be greater for MAFLD than for NAFLD. These data call for early identification and risk stratification of MAFLD and close collaboration between endocrinologists and hepatologists.