bluuebunny/crossref_metadata_2025_split huggingface dataset:
A real world cost-minimization analysis comparing the use of different endoscopic staplers in video-assisted thoracic surgery lobectomy procedures
Authors: Gu Wei , Wang Tao , Wang Wenting , Tong Guixian , Wu Shuqing , Han Yi 
Published: September 2021

Aim:
China’s cost-containment measures increasingly focus solely on the prices of consumable medical supplies without taking a broader perspective on differences in features and overall costs. This study compared two types of endoscopic staplers in video-assisted thoracoscopic surgery (VATS) lobectomy.
Materials & methods:
Electronic medical records for video-assisted thoracoscopic surgery from 2016 to 2017 were collected from a hospital in Anhui province. Two cohorts were retroactively defined based on stapler type. Total costs were compared using a cost-minimization analysis model. Probabilistic sensitivity analysis was performed.
Results:
In the base case, the group using more expensive staplers achieved overall cost savings of about $300 per procedure. Sensitivity analysis confirmed this result in 86.5% of cases.
Conclusion:
A price-only supply selection strategy may have unintended cost consequences.
EVALUATION OF THE SLIMMING EFFECTS OF DIET TEA IN BIOCHEMICAL AND MOLECULAR MEANING
Authors: EYUPOGLU Ozan Emre , ARMAN Buket Su 
Published: September 2021

The replacement of consumed with foods containing high carbohydrates, fats and proteins exceed that the daily needs of body, causes many health problems, especially obesity. Complicated health problems have been trying to be solved with drugs, but it is not possible to control diseases if obesity is not resolved. Obesity causes inflammation, insulin resistance, vascular endothelial dysfunction, and Low-Density Lipoprotein (LDL) increase. There are very few weight loss drugs with acceptable side effects, and these drugs are not given to people who are not considered obese according to their body mass index. For this reason, people seek the remedy in over the counter (OTC) (mostly products with active ingredients derived from plants) products or herbal teas. These products, which do not have direct effects, have mechanisms that can help and can be supportive with diet and sports. However, these products and teas that cannot be dosed by a knowledgeable healthcare professional can disrupt the balance of the body and cause various diseases. In this study, the effect levels with the mechanisms supporting weight loss on the biochemical parameters of the active substances in the herbal forms sold and consumed as diet tea, were evaluated.

Peer Review History:
Received: 4 July 2021; Revised: 11 August; Accepted: 6 September, Available online: 15 September 2021
Academic Editor: Dr. Jennifer Audu-Peter, University of Jos, Nigeria, drambia44@gmail.com
UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.5/10
Reviewers:
Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622, Giza, Egypt, gehankandeel9@yahoo.com
Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, maafayed@gmail.com
Optimización de un protocolo de extracción de ADN a partir de sangre bovina hemolizada y coagulada para la detección molecular de Anaplasma spp.
Authors: Landázuri Rafael Tomas Humberto , Carrazco Andrés , León Renato , Vinueza Lenin , Barragan Veronica 
Published: September 2021

La anaplasmosis es una enfermedad que puede afectar de manera significativa a la producción en el sector pecuario. Para la detección molecular por PCR de Anaplasma spp., se requiere de una extracción eficiente de ADN a partir de sangre completa, lo que a su vez depende de la calidad de la muestra de sangre. Fallas en los procedimientos de muestreo o conservación de las muestras pueden ocasionar hemolisis y coagulación de la sangre, lo que a su vez puede obstaculizar el diagnóstico. El objetivo de esta investigación fue optimizar un protocolo casero de bajo costo que utiliza resina de Chelex® 100 y permite detectar de manera eficiente a Anaplasma spp. en 30 muestras de sangre bovina hemolizada y coagulada. La eficiencia del protocolo optimizado se comparó con dos kits comerciales de extracción de ADN mostrando una alta concordancia (Kappa de Cohen = 0.72) en la detección molecular de Anaplasma spp. por PCR. Se recomienda esta metodología para superar las limitaciones de investigación que pueden surgir al extraer ADN a partir de muestras de sangre complejas.
Análisis de la rentabilidad apícola por estratos en Aguascalientes, México
Authors: Zavala Beltrán José Inés , López Santiago Marco Andrés , Valdivia Alcalá Ramón , Montiel Batalla Blanca Margarita 
Published: September 2021

La presente investigación se enfocó en analizar la estructura de costos y la rentabilidad en el proceso de producción de la apicultura. A través de técnicas de muestreo, se seleccionaron aleatoriamente 56 apicultores de un padrón de 230, mismos que se agruparon en tres estratos: productores de 20 a 50 colmenas (pequeños), 51 a 200 colmenas (medianos) y más de 200 colmenas (grandes). Se encontró que el costo económico de producción total se compone principalmente por el costo variable, con una participación promedio relativa de 55.4 % en los tres estratos. El gasto en alimentación es el concepto primordial, considerando que, para sostener la colmena, el 90.0 % de los apicultores alimentan con azúcar o fructosa cuando no hay floración. El costo fijo representa el 14.0 % respecto al total, la mayor erogación fue en el rubro de la depreciación en maquinaria y material de campo. Los costos de oportunidad representan el 30.6 % en promedio para los tres estratos. El rendimiento promedio por colmena fue de 25.4 kg/año. En conclusión, considerando el análisis económico, para el estrato I la actividad no es viable, ya que no considera el valor de todos los recursos en el proceso productivo (costos de oportunidad), así mismo en este estrato el ingreso principal proviene de otras actividades. En términos financieros, la actividad es viable en los tres estratos, lo que indica que se tiene la capacidad de cubrir costos fijos y costos variables. Al incluir los costos de oportunidad, los costos fijos y variables disminuyen.
Prevalence of dental caries in the Late Neolithic and Early Bronze Age populations from Żerniki Górne (Poland)
Authors: Tomczyk Jacek , Rusin Paweł , Zalewska Marta 
Published: September 2021

The aim of the studies is to describe the prevalence and distribution of dental caries in two pop­ulations from Żerniki Górne (Poland). The first population represented the Corded Ware Culture (CWC) (2550–2350 BC), and the second population belonged to the Trzciniec Culture (TC) (1300–1000 BC). While the TC is identified with a typically agricultural strategy, the CWC culture strategy is still debatable. Two types of strategies are indicated in the CWC, either a mixed or typical agricultural economy.
A total of 110 adults were examined, of which 29 represented the CWC and 81 belonged to the TC. A total of 1132 permanent teeth were examined (CWC 379, TC 753).
Of the 110 individuals, 54 individuals had dental caries (CWC 19/29, 66%; TC 35/81, 43%). In the CWC, 68% (13/19) of males and 60% (6/10) of females had dental caries. In the younger period (TC), the per­centage of dental caries among males was little higher (45%) than among females (41%). Dental caries was identified in 13% (50/379) of the teeth from the CWC. In the TC, the percentage of affected teeth were similar (11%, 82/753). The most common location of caries in all the chronological periods were the approximal and cemento-enamel junction [CEJ] surfaces. Caries on the occlusal surface was much less frequent. If we assume that an important cause of the development of dental caries is a high-carbohydrate diet, we can conclude that a similar prevalence of teeth affected by caries and it locations indicate a similar management strategy in both populations.
Performance and Consequences for Fecal Transplant in the Treatment of Pseudomembranous Colitis
Authors: Aurelia Hangan , Sorin Rugina , Elena Mocanu , Eugen Dumitru , Magdalena Dumitru Irina 
Published: September 2021

Abstract
Under conditions of increased consumption of antibiotics, pseudomembranous colitis has become a common condition in Romanian hospitals. Severe forms of the disease are becoming more common, recurrences are numerous, and metronidazole and vancomycin therapy has failed to prevent these recurrences. The study aims to identify the characteristics of patients who require a fecal transplant, the time for its performance and what are the short-term and possibly long-term consequences of this method.
We analyzed 26 patients who had a fecal transplant with a favorable evolution in 96%. We consider that FMT is an effective method for preventing recurrent CDI but also for those with resistance to the usual antibiotics.
Proteomic Implications of Tumoral Infiltrating Lymphocytes in Melanoma: PD-L1, CD4 and CD8 - Short Review
Authors: Antonela Nicolau Anca , Marian Caraban Bogdan , Emma Gheorghe , Laurentiu Hangan Tony , Oana Cojocaru , Ionut Orasanu Cristian , Ioana Voda Raluca 
Published: September 2021

Abstract
Melanoma is a tumor developed by malignancy of melanocytes, being one of the most lethal cancers. Usually, it is associated with exposure to ultraviolet radiations, being most common in the skin, but can also be located extracutaneously as in the digestive tract, leptomeninges or uvea. Histopathologically it presents a phase of radial growth and a vertical one, often accompanied by an intra and peritumoral inflammatory infiltrate. Immunohistochemically, the confirmation of the diagnosis of melanoma should be accompanied by the assessment of proteomic markers of lymphocytic infiltrate such as PD-L1, CD4 and CD8. Those have a role in evaluating the prognosis and a possible prediction of the immunotherapeutic response.
The Efficiency of the Fight Against HIV, in Constanta, from the Perspective of Neurological Complications
Authors: Corina Pascu , Magdalena Dumitru Irina , Carmen Cernat Roxana , Cristian Petcu Lucian , Sorin Rugina 
Published: September 2021

Abstract
In order to control and end the AIDS epidemic, we all need to hit the 0-0-0 target. That means 0 HIV infections, 0 mortality caused by AIDS and 0 discrimination. We performed a retrospective observational analytical study on 166 HIV positive patients with a neurological complication, diagnosed between June 2012 and June 2020, in Clinical Infectious Diseases Hospital of Constanta. We collected data from the observational charts that revealed if the patient was known with HIV infection at the time of the neurological complication diagnosis, information about the treatment (how many treatment regimens, classes of antiretroviral drugs, CNS Penetration-Effectiveness Rank), treatment compliance. The patients were divided into two groups: first group “opportunistic infections (OI)” and second group “other neurological conditions (ONC)”. 16 patients (9,6%) have the neurological condition as first manifestation of HIV infection. Opportunistic infections, correlated with a poor immunological status continue to have a high percentage (46,98%) of neurological complications, being associated with a poor treatment compliance (p<0,001). Integrase inhibitors were associated, in this study, more with opportunistic infections and less with other neurological conditions (OR=2,885; 95% IC), this finding needs further research. Long term survivors have problems with treatment compliance manifesting treatment fatigue, even if they have treatment regimens with good CNS penetrability. Poor compliance is associated with high risk of opportunistic infections and opportunistic infections have a higher mortality than other neurological complications. Our task for the future is to find ways to improve treatment adherence in order for HIV patients to have a better and longer life.
Square Slot Antenna for Wide Circularly Polarized Bandwidth and Axial Ratio Beamwidth
Authors: Sharma Vijay , Jhajharia Tejpal 
Published: September 2021

Abstract
The article proposes design investigation and experimental results of a coplanar waveguide (CPW) fed square slot antenna that gives wideband circular polarization. This circular polarization characteristic is achieved by embedding a square shape stub to left bottom corner and an L-shaped strip to the right upper corner of the slot. A high impedance bandwidth of 87.8 % (3.6–9.0 GHz), a wide axial ratio bandwidth of 73.05 % (4.2–9.0 GHz) and wide 3-dB axial ratio beamwidth of 90° in the entire frequency range of interest are achieved with this antenna structure. To improve the 3-dB axial ratio bandwidth, three slots (two horizontal and one vertical) are scratched at the exterior periphery of the ground plane. These perturbation assemblies are accountable to excite orthogonal modes and help increase an axial ratio bandwidth. The designed antenna displays the constant and steady radiation patterns in the complete frequency range of concern. The overall dimension of the presented compact antenna is 0.24λ × 0.24λ × 0.01λ.
Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?
Authors: Tomo Sojit , Banerjee Mithu , Sharma Praveen , Garg Mahendra 
Published: September 2021

Abstract
The pathophysiology of COVID comprises an exaggerated pro-inflammatory response. Hypothalamic-pituitary-adrenal (HPA) axis has a crucial role in various inflammatory conditions and modulated immunological response. Limited evidence is available regarding the incidence and the effect of HPA dysfunction in COVID-19. Although the cortisol levels have only been estimated in a few studies, the dehydroepiandrosterone sulfate (DHEAS) release from the adrenal gland has not been explored yet. In this mini review, the authors discuss the role of dehydroepiandrosterone (DHEA) and DHEAS in the acute stress response and immunological modulation. Various effects of DHEAS have been demonstrated in different diseases. The specific inhibitory effect of DHEA on interleukin 6 (IL-6) could be of paramount importance in COVID-19. Further, DHEA supplementation has already been proposed in inflammatory conditions, like rheumatoid arthritis. DHEAS levels in COVID-19 may help to understand the HPA axis dysfunction as well as the possibility of repurposing DHEA as a drug for mitigating the pro-inflammatory COVID-19.
Selected 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors. A look into their use and potential in pre-diabetes and type 2 diabetes
Authors: Barre Douglas Edward , Mizier-Barre Kazimiera Amelia 
Published: September 2021

Abstract

Objectives. This review assesses the comparative safety and efficacy of selected 3-hydroxy-3-methylglutaric acid coenzyme A inhibitors (statins, cinnamic acids. 3-hydroxy-3-methyl glutaric acid) on the pre-onset type 2 diabetes (PT2D) and post-onset type 2 diabetes (T2D)-related cluster of seven features (central obesity, hyperglycemia, hypertension, dyslipidemia, pro-thrombosis, oxidation and inflammation).

Methods. Google scholar and PubMed were searched for statin*, flaxseed lignan complex (FLC), cinnamic acid (CA)*, and 3-hydroxy-3-methylglutaric acid (HMGA) in conjunction with each of PT2D, T2D and the cluster of seven. An introduction was followed by findings or absence thereof on the impacts of each of statins, FLC, CAs and HMGA on each member of the cluster of seven.

Results. Pravastatin manages three features in PT2D, while a number of the statins improve five in T2D. FLC is negative in PT2D but controls four in T2D; it is not clear if the CAs and HMGA in FLC play a role in this success. CAs have potential in six and HMGA has potential in three of the cluster of seven though yet CAs and HMGA are untested in PT2D and T2D in humans. There are safety concerns with some statins and HMGA but FLC and CAs appear safe in the doses and durations tested.

Conclusions. Selected statins, FLC, CAs and HMGA can manage or have a potential to manage at least three features of the cluster of seven. Most of the literature-stated concerns are with select statins but there are concerns (one actual and two potential) with HMGA.
In Search of Outcomes of a Psychological Contract in Public Organisation
Authors: Bera Agata 
Published: September 2021

Abstract

Background
Sustainable development of employees is based primarily on practices oriented towards caring for the relationship between the employer and employee. In this approach, the employee's and the employer's perception of mutual obligations, the employee's belief in the conditions for the exchange of mutual experiences with the employer, and mutual obligations resulting from establishing an employer-employee relationship become important factors and elements of the sustainable development strategy of employees. A growing number of soundscape studies involve a psychological contract literature. However, outcomes have not yet been thoroughly reviewed. The need for a study with this purpose is proven by the fact that academic literature lacks a systematic review of this topic, despite the ascending trend in the number of published articles in the field. Therefore, this study aims at identifying the main outcomes of a psychological contract in public organisations.

Research aims
The purpose of this literature review was to identify the main effects of psychological contracting in public organisations. We also aimed to collect fragmented academic knowledge produced by pertinent studies.

Methodology
This article adopts the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) approach to conduct the systematic literature review. The final sample of 41 empirical and conceptual studies were scientifically screened and synthesised.

Findings
This study establishes that a psychological contract is a complex phenomenon influencing individual, group, and organisational outcomes directly. The application of a systematic literature review demonstrates the importance of a psychological contract for public organisations. The review suggests an agenda for further research and identifies practical implications for public organisations.
Efficient fault identification scheme of compensated transmission grid based on correlated reactive power measurements and discrete wavelet transform
Authors: Zaki Mohamed I. , El-Sehiemy Ragab A. , Amer Ghada M. 
Published: September 2021

Abstract
The early fault identification in high-voltage power systems is a substantial aspect not only to minimize equipment failure but also to increase both the reliability and stability in power system. Subsequently, the aim of this paper is to propose the adaptive fault-identification scheme based on multi-resolution analysis technique. The proposed method is dependent on monitoring both voltages and currents from single-ended measuring system. The correlation among the reactive power computation and discrete wavelet transform is used to generate the significant criteria which are used to discriminate between short-circuit currents and energizing heavy loads behaviour. Different transmission network configurations are investigated to assess the dependability, security, and reliability of fault identification relay as well. The correlative protection scheme attains the accurate results under healthy disturbances, and therefore it is superior to other conventional approaches. In addition, a selective study is applied to different mother wavelets to find the best one. The response of the proposed scheme to the compensated transmission line is also verified at a wide range of compensation levels with faults before and after compensated bank. Simulation tests have been handled via ATP-EMTP to investigate the proper practicability and adaptability of the fault-identication relay.
Frequency domain despeckling technique for medical ultrasound images
Authors: Al-Asad Jawad F. , Mewada Hiren K. , Khan Adil H. , Abu-Libdeh Nidal , Nayfeh Jamal F. 
Published: September 2021

Abstract
This work proposes a novel frequency domain despeckling technique pertaining to the enhancement of the quality of medical ultrasound images. The results of the proposed method have been validated in comparison to both the time-domain and the frequency-domain projections of the schur decomposition as well as with several other benchmark schemes such as frost, lee, probabilistic non-local means (PNLM) and total variation filtering (TVF). The proposed algorithm has shown significant improvements in edge detection and signal to noise ratio (SNR) levels when compared with the performance of the other techniques. Both real and simulated medical ultrasound images have been used to evaluate the numerical and visual effects of each algorithm used in this work.
Design of dual-band implanted patch antenna system for bio-medical applications
Authors: Zaki Ahmed Z. A. , Abouelnaga Tamer Gaber , Hamad Ehab K. I. , Elsadek Hala A. 
Published: September 2021

Abstract
In this paper, a miniaturized implantable antenna system for biomedical applications is presented. The system consists of almost two similar patch antennas, named internal and external. The internal antenna is implanted inside the body at a depth of 2 mm, and the external antenna is to be attached to the body aligned with the internal one. The antenna system consists of implant-side antenna with dimensions are 10.25×10.25×1.27 mm3 , while the external antenna dimensions are 11.1×11.1×1.27 mm3. The proposed antennas designs showed dual resonant frequency on ISM bands (ie , 915 MHz and 2450 MHz
). The computed -10 dB bandwidth considering three-layer human phantom demonstrates that a bandwidth of 870 to 970 MHz and 2.38 to 2.47 GHz for internal and external antennas are achieved. The Specific Absorption Rate (SAR) has been considered for health care consideration. The measured and simulated scattering parameters are compared, and good agreements are achieved. The proposed antenna system is simulated and investigated for biomedical applications suitability.