bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrical Conductivity in Texturally Equilibrated Fluid‐Bearing Forsterite Aggregates at 800°C and 1 GPa: Implications for the High Electrical Conductivity Anomalies in Mantle Wedges
Authors: Huang Yongsheng , Guo Haihao , Nakatani Takayuki , Uesugi Kentaro , Nakamura Michihiko , Keppler Hans 
Published: March 2021

AbstractAqueous fluids are one of the principal agents of chemical transport in Earth´s interior. The precise determination of fluid fractions is essential to understand bulk physical properties, such as rheology and permeability, and the geophysical state of the mantle. Laboratory‐based electrical conductivity measurements are an effective method for estimating the fluid distribution and fraction in a fluid‐bearing rock. In this study, the electrical conductivity of texturally equilibrated fluid‐bearing forsterite aggregates was measured for the first time with various fluid fractions at a constant salinity of 5.0 wt.% NaCl at 1 GPa and 800°C. We found that the electrical conductivity nonlinearly increases with increasing fluid fraction, and the data can be well reproduced by the modified Archie's law. The three‐dimensional (3‐D) microstructure of the interstitial pores visualized by the high‐resolution synchrotron X‐ray computed micro‐tomography (CT) shows a change in fluid distribution from isolated pockets at a fluid fraction of 0.51 vol.% to interconnected networks at fluid fractions of 2.14 vol.% and above due to grain anisotropy and grain size differences, accounting for the nonlinear increase in electrical conductivity. The rapid increase in conductivity indicates that there is a threshold fluid fraction between 0.51 and 2.14 vol.% for forming interconnected fluid networks, which is consistent with the 3‐D images. Our results provide direct evidence that the presence of >1.0 vol.% aqueous fluid with 5.0 wt.% NaCl is required to explain the high conductivity anomalies above 0.01 S/m detected in deep fore‐arc mantle wedges.
Model and Satellite Analysis of Transport of Asian Anthropogenic Pollution to the Arctic: Siberian and Pacific Pathways and Their Meteorological Controls
Authors: Ikeda Kohei , Tanimoto Hiroshi , Sugita Takafumi , Akiyoshi Hideharu , Clerbaux Cathy , Coheur Pierre‐François 
Published: March 2021

AbstractWe made comprehensive analyses of long‐range transport episodes of air pollutants from East Asia to the Arctic and associated meteorological conditions. While our main focus was black carbon (BC) as its transport to the Arctic has attracted great attention, carbon monoxide (CO) was also diagnosed as a species co‐emitted with BC and as a tracer of long‐range transport. We used satellite observations by the Infrared Atmospheric Sounding Interferometer (IASI) and a newly implemented BC tagged‐tracer simulation using a global chemical transport model, GEOS‐Chem. Temporal variations of IASI‐CO column over the Pacific Arctic (160–200°E, 60–80°N) showed that episodic increases occurred several times in each season. For the period of 2007–2011, 11 strong events (6 in spring, 3 in autumn, and 2 in winter) caused by the long‐range transport from East Asia were identified. Two transport pathways from East Asia to the Arctic were found: over Siberia and the Sea of Okhotsk, and over the North Pacific. In the pathway over Siberia and the Sea of Okhotsk, the pollutants were transported northeastward from China mainly through the Sea of Okhotsk and East Siberia. The low pressures passing from East Siberia to the Sea of Okhotsk played important roles in the transport in the lower troposphere and uplifting to the middle troposphere. In the pathway over the North Pacific, the pollutants were transported eastward from the Asian continent and subsequent northward transport took place over the North Pacific. The poleward transport occurred west of the high pressure that stayed around the Bering Sea.
Burial, Accretion, and Exhumation of the Metamorphic Sole of the Oman‐UAE Ophiolite
Authors: Ambrose T. K. , Waters D. J. , Searle M. P. , Gopon P. , Forshaw J. B. 
Published: March 2021

AbstractWe conducted petrological analyses of samples collected across a 250‐m thick section of the metamorphic sole of Oman‐United Arab Emirates ophiolite. Thermobarometric calculations on garnet‐clinopyroxene amphibolites (retrogressed granulites) from the top 85 m of sole indicate peak pressure‐temperature conditions of 700°–900°C and 10–12 kbar, corresponding to depths of 30–40 km. Structurally lower (85–250 m below peridotite) epidote amphibolites record similar pressures, but temperatures that are ∼100°C lower. We document progressive retrogression of the peak granulite facies assemblage down through amphibolite and greenschist facies pressure‐temperature conditions. We propose that pervasive granulite formation in metabasic rocks along the top of the downgoing slab resulted in rheological strengthening that caused the subduction interface to migrate downwards and accrete a slice (the high‐temperature sole) to the hanging‐wall mantle. Structurally lower thrust slices of epidote and bimineralic amphibolites, as well as interlayered metasedimentary rocks, were subsequently underplated at similar pressures of 10–12 kbar, but lower temperatures, as the subduction zone cooled. Prograde metamorphism of these lower‐grade thrust slices released fluids that (re)hydrated the overlying granulites and hanging‐wall peridotites. Along with several other recent studies, our results indicate that the base of the ophiolite and the granulite‐amphibolite facies part of the metamorphic sole were juxtaposed at depths of 30–40 km. Our results are consistent with other observations from the metamorphic sole and base of the ophiolite that indicate the sole was exhumed along a flattening slab.
3‐D Deep Electrical Resistivity Tomography of the Major Basin Related to the 2016 Mw6.5 Central Italy Earthquake Fault
Authors: Sapia V. , Villani F. , Fischanger F. , Lupi M. , Baccheschi P. , Pantosti D. , Pucci S. , Civico R. , Sciarra A. , Smedile A. , Romano V. , De Martini P. M. , Murgia F. , Materni V. , Giannattasio F. , Pizzimenti L. , Ricci T. , Brunori C. A. , Coco I. , Improta L. 
Published: March 2021

AbstractWe provide the first 3‐D resistivity image of the Pian Grande di Castelluccio basin, the main Quaternary depocenter in the hangingwall of the Mt.Vettore–Mt. Bove normal fault system (VBFS), responsible for the October 30, 2016 Mw6.5 Norcia earthquake (central Italy). The subsurface structure of the basin is poorly known, and its relation with the VBFS remains debated. Using the recent Fullwaver technology, we carried out a high‐resolution 2‐D transect crossing the 2016 coseismic ruptures coupled with an extensive 3‐D survey with the aim of: (a) mapping the subsurface of the basin‐bounding splays of the VBFS and the downdip extent of intrabasin faults; (b) imaging the infill and pre‐Quaternary substratum down to ∼1 km depth. The 2‐D resistivity section highlights under the coseismic ruptures a main dip‐slip fault zone with conjugated splays. The 3‐D resistivity model suggests that the basin consists of two depocenters (∼300 and ∼600 m deep, respectively) filled with silty sands and gravels (resistivity <300 Ωm), bounded and cross‐cut by NNE‐, WNW‐, and NNW‐trending faults with throws of ∼200–400 m. We hypothesize that the NNE‐trending system acted during the early basin development, followed by NNW‐trending and currently active splays of the VBFS that overprint pre‐existing structures and locally control the infill architecture. Moreover, beneath the basin we detect a shallow NW‐dipping blind fault. The latter is likely a hangingwall splay of the adjacent regional Mts. Sibillini Thrust, which may have been partly involved in the rupture process of the Norcia mainshock.
The incorporation loci of H3.3K36M determine its preferential prevalence in chondroblastomas
Authors: Zhang Yanjun , Fang Dong 
Published: March 2021

AbstractThe histone H3.3K36M mutation, identified in over 90% of chondroblastoma cases, reprograms the H3K36 methylation landscape and gene expression to promote tumorigenesis. However, it’s still unclear how the H3K36M mutation preferentially occurs in the histone H3 variant H3.3 in chondroblastomas. Here, we report that H3.3K36M-, but not H3.1K36M-, mutant cells showed increased colony formation ability and differentiation defects. H3K36 methylations and enhancers were reprogrammed to different status in H3.3K36M- and H3.1K36M-mutant cells. The reprogramming of H3K36 methylation and enhancers was depended on the specific loci at which H3.3K36M and H3.1K36M were incorporated. Moreover, targeting H3K36M-mutant proteins to the chromatin inhibited the H3K36 methylation locally. Taken together, these results highlight the roles of the chromatic localization of H3.3K36M-mutant protein in the reprogramming of the epigenome and the subsequent induction of tumorigenesis, and shed light on the molecular mechanisms by which the H3K36M mutation mainly occurs in histone H3.3 in chondroblastomas.
Circ-HMGA2 (hsa_circ_0027446) promotes the metastasis and epithelial-mesenchymal transition of lung adenocarcinoma cells through the miR-1236-3p/ZEB1 axis
Authors: Yu Zhongjian , Zhu Xiongjie , Li Ying , Liang Min , Liu Meijun , Liu Zhile , Qin Lingyu , Wu Xiaoran , Du Kunpeng , Liu Lu , Wang Yong , Zheng Yanfang 
Published: March 2021

AbstractLung adenocarcinoma (LUAD) has high incidence and mortality rates worldwide; however, its detailed molecular pathology remains unclear. Although circRNAs have gradually been identified as molecules that are differentially expressed in tumors and play key roles in tumor progression, their role in LUAD is poorly understood. Through microarray analysis, we obtained the circRNA expression profile of LUAD and found that circ-HMGA2 (hsa_circ_0027446), a novel RNA, is highly expressed in LUAD. The high expression of circ-HMGA2 was further verified in 36 paired LUAD and adjacent normal tissues. Functionally, circ-HMGA2 promoted LUAD cell metastasis in vitro and in vivo. The luciferase reporter assay and FISH results showed that circ-HMGA2 interacts with miR-1236-3p and that miR-1236-3p interacts with ZEB1. In addition, miR-1236-3p was expressed at low levels in LUAD, inhibited LUAD cell metastasis, and suppressed the function of circ-HMGA2. ZEB1 is an EMT-promoting transcription factor. The PCR and WB analysis results showed that circ-HMGA2 promotes both ZEB1 expression and EMT. MiR-1236-3p had the opposite effect, reversing the promotive effect of circ-HMGA2 on EMT. In summary, circ-HMGA2 promotes LUAD cell metastasis through the miR-1236-3p/EMT axis, indicating that it could be a therapeutic target in LUAD.
Environment impact and probabilistic health risks of PAHs in dusts surrounding an iron and steel enterprise
Authors: Wei Xiaofeng , Ding Chun , Chen Chunzhu , Zhu Li , Zhang Guiqin , Sun Youmin 
Published: March 2021

AbstractDust can be regarded as environmental medium that indicates the level and spatial distribution of polycyclic aromatic hydrocarbons (PAHs) coming from different pollution sources. In this study, samples including road dust, roof dust, and bare soil near an iron and steel enterprise (ISE) in Laiwu city of North China were collected. To assess the environment impact, atmosphere particulates and one flue dust from a coking plant were simultaneously sampled. Sixteen USEPA PAHs were detected quantitatively by Gas Chromatography Mass Spectrometry (GC–MS). A laser particle size analyzer was used to obtain the grain size of the dust particle samples. The results showed that PAH concentrations displayed great variability in the dust samples. The ∑16PAHs concentration was found to be between 0.460 and 46.970 μg/g (avg ± sd 10.892 ± 1.185 μg/g) in road dust, between 0.670 and 17.140 μg/g (avg ± sd 6.751 ± 0.692 μg/g) in roof dust, and 13.990 ± 1.203 μg/g in bare soil. In the environment atmosphere sites, the ∑16 PAHs value in PM2.5 constituted a very large proportion of PM10, indicating that PAHs in finer particle sizes should be given greater emphasis. The ∑16PAHs concentration was relatively high in the area close to the ISE because of the great impact of the ISE industrial activities. PAH concentration curves were similar, and the most abundant individual PAHs in the atmosphere sites were BbF, BkF, and Flu, and BbF, BkF, and Chry in dusts. Toxicity analysis revealed that PAHs with four rings, including carcinogenic PAHs, were the dominant pollutants in the studied area. The toxic equivalency value (TEQBaP), the carcinogenic health risk assessment value recommended by the US EPA, was calculated for seven carcinogenic PAHs, revealing that they account for more than 93.0% of the total TEQBap of the 16 PAHs and indicating the major toxic equivalent concentration contributor. Incremental lifetime cancer risk (ILCR) estimation results showed that PAHs tended to bring about great health risks through skin contact, followed by ingestion and inhalation. By comparison, road dust exhibited greater carcinogenic risks than roof dust, and bare soil may undergo heavier pollution. Therefore, the results of this study would be helpful in the effort to understand the PAHs pollution from the steel industry, which will provide some guidance for the probabilistic assessment of local health risks.
Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement
Authors: Blum Leonore , Rosenbaum David , Röben Benjamin , Dehnen Katja , Maetzler Walter , Suenkel Ulrike , Fallgatter Andreas J. , Ehlis Ann-Christine , Metzger Florian G. 
Published: March 2021

AbstractIn our aging society, research into neurodegenerative processes is of great interest. Thereby, cortical activation under different neurocognitive conditions is considered to be a promising predictor. Against this background, the executive functions of a total of 250 healthy older adults (53–84 years) have been investigated using the Trail Making Test (TMT) and functional near-infrared spectroscopy in a block design. We investigated effects of age on the performance and cortical blood oxygenation during the TMT. Since it is assumed that older people may compensate for cognitive deficits by slowing their processing speed, we additionally analyzed the cortical blood oxygenation per solved item. Our results showed a significant decrease in processing speed in older participants compared to middle-aged individuals, however, also lower error rates during TMT part A. On a neurophysiological level, we observed increased cortical blood oxygenation in the older participants when completing the TMT. Finally, with respect to the combined measurement (O2Hb/item), no significantly higher hemodynamic cortical response per item was found within the older participants. The results confirm a deterioration of cognitive performance and an increase of cortical activity with increasing age. The findings are discussed in the light of current research.
Clinical study of diabetic peripheral neuropathy screening by retinal vascular geometric parameters
Authors: Hu Guotao , Wu Hongmei , Kuang Lei , Zee Benny Chung-Ying , Huang Ying , Huang Zhen , He Li , Zeng Yuanhong , Gao Yongbo , Wang Hailan 
Published: March 2021

AbstractTo investigate the relationship between geometrical changes of retinal vessels and diabetic peripheral neuropathy(DPN), and to determine the effectiveness of retinal vascular geometry analysis and vibration perception threshold (VPT) for DPN assessment. Type 2 diabetes patients (n = 242) were categorized by stage of DPN. VPT and fundus photography was performed to obtain retinal vascular geometry parameters. The risk factors for DPN and the correlation between DPN stages were analyzed. The efficiency of the retinal vascular geometric parameters obtained with VPT as a diagnostic tool for DPN was examined. Stages of DPN showed a linear correlation with VPT (r = 0.818), central retinal vein equivalent (CRVE) (r = 0.716), and fractal dimension arterioles (DFa) (r = − 0.769). VPT, CRVE, DFa, and fractal dimension veins (DFv) showed high sensitivity (80%, 55%, 82%, and 67%, respectively) and specificity (92%, 93%, 82%, and 80%, respectively) for DPN diagnosis. Good agreement was observed between combined use of geometric parameters (CRVE, DFa and DFv) and VPT (Kappa value 0.430). The detection rate of DPN with combined use of geometric parameters of retinal vessels (64.88%) was significantly higher than that with use of VPT (47.52%). Retinal vascular geometry changes demonstrated significant correlation with DPN severity. VPT, CRVE, DFa, and DFv may provide insights for understanding DPN.
Identification and in vitro antifungal susceptibility of causative agents of onychomycosis due to Aspergillus species in Mashhad, Iran
Authors: Xu Xue , Naseri Ali , Houbraken Jos , Akbari Farzaneh , Wang Xiaodong , Zhao Rongfen , Zhang Hong , Najafzadeh Mohammad Javad , Deng Shuwen 
Published: March 2021

AbstractAspergillus species are emerging causative agents of non-dermatophyte mold onychomycosis. In this study, 48 Aspergillus isolates were obtained from patients with onychomycosis in Mashhad, Iran, during 2015–2018. The aim is to identify the Aspergillus isolates to the species level by using partial calmodulin and beta-tubulin gene sequencing and MALDI-TOF MS, and to evaluate their in vitro susceptibility to ten antifungal drugs: terbinafine, itraconazole, voriconazole, posaconazole, ravuconazole, isavuconazole, caspofungin, micafungin, anidulafungin and amphotericin B according to CLSI M38-A3. Our results indicate that A.flavus (n = 38, 79%) is the most common Aspergillus species causing onychomycosis in Mashhad, Iran. Other detected species were A. terreus (n = 3), A. tubingensis (n = 2), A. niger (n = 1), A. welwitschiae (n = 1), A. minisclerotigenes (n = 1), A. citrinoterreus (n = 1) and A. ochraceus (n = 1). Aspergillus flavus, A. terreus and A. niger isolates were correctly identified at the species level by MALDI-TOF MS, while all cryptic species were misidentified. In conclusion, A. flavus is the predominant Aspergillus species causing onychomycosis due to Aspergillus spp. in Mashhad, Iran. MALDI-TOF MS holds promise as a fast and accurate identification tool, particularly for common Aspergillus species. It is important that the current database of reference spectra, representing different Aspergillus species is expanded to increase the precision of the species-level identification. Terbinafine, posaconazole and echinocandins were in vitro most active against the studies Aspergillus isolates and terbinafine could be the first choice for treatment of onychomycosis due to Aspergillus.
Effects of three pulmonary ventilation regimes in patients undergoing coronary artery bypass graft surgery: a randomized clinical trial
Authors: Amin Revati , Alaparthi Gopala Krishna , Samuel Stephen R. , Bairapareddy Kalyana Chakravarthy , Raghavan Harish , Vaishali K. 
Published: March 2021

AbstractThe aim was to compare the effect of diaphragmatic breathing exercise (DBE), flow- (FIS) and volume-oriented incentive spirometry (VIS) on pulmonary function- (PFT), functional capacity-6-Minute Walk Test (6 MWT) and Functional Difficulties Questionnaire (FDQ) in subjects undergoing Coronary Artery Bypass Graft surgery (CABG). The purpose of incorporating pulmonary ventilator regimes is to improve ventilation and avoid post-operative pulmonary complications. CABG patients (n = 72) were allocated to FIS, VIS and DBE groups (n = 24 each) by block randomization. Preoperative and postoperative values for PFT were taken until day 7 for all three groups. On 7th postoperative day, 6 MWT and FDQ was analyzed using ANOVA and post-hoc analysis. PFT values were found to be decreased on postoperative day 1(Forced Vital Capacity (FVC) = FIS group—65%, VIS group—47%, DBE group—68%) compared to preoperative day (p < 0.001). PFT values for all 3 groups recovered until postoperative day 7 (FVC = FIS group—67%, VIS group—95%, DBE group—59%) but was found to reach the baseline in VIS group (p < 0.001). When compared between 3 groups, statistically significant improvement was observed in VIS group (p < 0.001) in 6 MWT and FDQ assessment. In conclusion, VIS was proven to be more beneficial in improving the pulmonary function (FVC), functional capacity and FDQ when compared to FIS and DBE.
Effects of practitioner’s experience on the clinical performance of ultrasound-guided central venous catheterization: a randomized trial
Authors: Yoon Hyun-Kyu , Hur Min , Cho Hyeyeon , Jeong Young Hyun , Lee Ho-Jin , Yang Seong-Mi , Kim Won Ho 
Published: March 2021

AbstractWe investigated whether two needle insertion techniques for ultrasound-guided internal jugular vein (IJV) catheterization differ in the number of needling attempts and complication rate between inexperienced and experienced practitioners. A total of 308 patients requiring IJV catheterization were randomly assigned into one of four groups: IJV catheterization performed by inexperienced practitioners using either Seldinger (IE-S; n = 78) or modified Seldinger technique (IE-MS; n = 76) or IJV catheterization performed by experienced practitioners using either Seldinger (E-S; n = 78) or modified Seldinger technique (E-MS; n = 76). All catheterizations were performed under the real-time ultrasound guidance. The number of needling attempts was not significantly different between the two techniques within each experience group (between IE-S vs. IE-MS P = 0.550, between E-S and E-MS P = 0.834). Time to successful catheterization was significantly shorter in the E-S group compared to E-MS group (P < 0.001) while no significant difference between IE-S and IE-MS groups (P = 0.226). Complication rate was not significantly different between the two techniques within each experience group. Practitioner’s experience did not significantly affect the clinical performance of needle insertion techniques during ultrasound-guided IJV catheterization except the time to successful catheterization. Regarding the number of needling attempts and complication rate, both techniques could be equally recommended regardless of practitioner’s experience.Trial registration: clinicaltrials.gov (https://clinicaltrials.gov/ct2/show/NCT03077802).
Lower local recurrence rate after robot-assisted thoracoscopic esophagectomy than conventional thoracoscopic surgery for esophageal cancer
Authors: Motoyama Satoru , Sato Yusuke , Wakita Akiyuki , Nagaki Yushi , Fujita Hiromu , Sasamori Ryohei , Kemuriyama Kohei , Takashima Shinogu , Imai Kazuhiro , Minamiya Yoshihiro 
Published: March 2021

AbstractThe oncological advantages of robot-assisted thoracoscopic esophagectomy (RATE) over conventional thoracoscopic esophagectomy (TE) for thoracic esophageal cancer have yet to be verified. In this study, we retrospectively analyzed clinical data to compare the incidences of recurrence within the surgical field after RATE and TE as an indicator of local oncological control. Among 121 consecutive patients with thoracic esophageal or esophagogastric junction cancers for which thoracoscopic surgery was indicated, 51 were treated with RATE while 70 received TE. The number of lymph nodes dissected from the mediastinum, duration of the thoracic portion of the surgery, and morbidity due to postoperative complications did not differ between the two groups. However, the rate of overall local recurrence within the surgical field was significantly (P = 0.039) higher in the TE (9%) than the RATE (0%) group. Lymph node recurrence within the surgical field occurred in left recurrent nerve, left tracheobronchial, left main bronchus and thoracic paraaortic lymph nodes, which were all difficult to approach to dissect. The other two local failures occurred around the anastomotic site. This study indicates that using RATE enabled the incidence of recurrence within the surgical field to be reduced, though there were some limitations.