bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skeletally immature patient showed lower graft maturity than skeletally mature patient after ACL reconstruction with a rounded rectangular femoral tunnel
Authors: Asai Kazuki , Nakase Junsuke , Shimozaki Kengo , Yoshimizu Rikuto , Kimura Mitsuhiro , Tsuchiya Hiroyuki 
Published: October 2021

AbstractTo compare the clinical results and ligamentization of anterior cruciate ligament reconstruction (ACLR) between skeletally immature and mature patients. Two-hundred-and-two patients who underwent primary ACLR were evaluated retrospectively. The clinical outcomes were compared between skeletally immature (immature group 1, n = 27) and mature (control group 1, n = 175) groups. Graft ligamentization of the reconstructed anterior cruciate ligament (ACL) using magnetic resonance imaging (MRI) signal intensity at 6 months postoperatively was compared between immature group 2 (n = 16), which included participants from immature group 1, and control group 2 (n = 32), created by recruiting data-matched controls from control group 1. Immature group 1 had significantly higher revision (14.8%) and pivot shift test positive (22.2%) rates than control group 1 (2.9% and 4.0%, respectively) (P = 0.020 and 0.003, respectively). The signal intensity in immature group 2 were significantly higher at the mid-substance and distal site of the reconstructed ACL than those in control group 2 (P = 0.003 and 0.034, respectively). Skeletally immature patients had higher graft revision and residual rotational laxity rates. Reconstructed ACL in skeletally immature patients showed higher signal intensity on MRI at 6 months postoperatively.
Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration
Authors: Hirai Hiromasa , Yamashita Mariko , Matsumoto Masanori , Hayakawa Masaki , Sakai Kazuya , Ueda Tetsuo , Ogata Nahoko 
Published: October 2021

AbstractPachychoroid neovasculopathy (PNV) is a new concept of macular disorder. Some cases diagnosed as age-related macular degeneration (AMD) have been re-diagnosed as PNV. However, the biological features of PNV are still uncertain. The purpose of this study was to compare PNV and AMD by analyses focusing on von Willebrand factor (VWF) and complement factor H (CFH). Ninety-seven patients who were previously diagnosed with treatment naïve AMD were enrolled in this study. They were re-classified as either PNV or AMD based on the clinical criteria and 33 patients were classified as PNV and 64 patients as AMD. We examined the clinical data, analyzed VWF multimer and two genetic polymorphisms (I62V and Y402H) in the CFH. PNV group was significantly younger than AMD group (P = 0.001). In both I62V and Y402H, there were no significant differences between PNV and AMD while the recessive homozygous (AA) was found only in PNV group in I62V. The presence of unusually large VWF multimers (UL-VWFMs) and subretinal hemorrhages were significantly higher in PNV than in AMD (P = 0.045, P = 0.020, respectively). Thus, the residual UL-VWFMs may result in platelet thrombosis and hemorrhages in the choriocapillaris of PNV. In conclusion, our results suggest the biological differences between PNV and AMD.
Nutritional behaviors of women and men in Poland during confinement related to the SARS-CoV-2 epidemic
Authors: Bolesławska Izabela , Błaszczyk-Bębenek Ewa , Jagielski Paweł , Jagielska Anna , Przysławski Juliusz 
Published: October 2021

AbstractThe influence of the confinement on the changes of eating behaviors in men and women in Poland and between groups were assessed. Results were obtained for 112 men and 200 women. An anonymous questionnaire available on-line from 29 April to 19 May 2020 was the research tool. It contained questions about the frequency of consumption "before" and "during" confinement. Additionally, anthropometric measurements were declared by the respondents. An increase in the number of meals and an improvement in their regularity were observed in both groups. However, the frequency of snacking also increased. During lockdown women consumed potatoes, sweets, canned meat and eggs and men consumed canned meat more frequently. Products consumed less frequently were: fast food, instant soups and energy drinks (women), and white bread and fast food (men). The frequency of alcohol consumption also increased during lockdown. Average body weight and BMI increased significantly during social isolation. Body weight increase was declared by almost half of women and 40% of men. During the blockade period caused by the COVID-19 pandemic, changes in the dietary behavior of the study group of women and men were found. The nature of these changes varied according to gender and the dietary parameters analyzed.
Spatially explicit paleogenomic simulations support cohabitation with limited admixture between Bronze Age Central European populations
Authors: Rio Jérémy , Quilodrán Claudio S. , Currat Mathias 
Published: October 2021

AbstractThe Bronze Age is a complex period of social, cultural and economic changes. Recent paleogenomic studies have documented a large and rapid genetic change in early Bronze Age populations from Central Europe. However, the detailed demographic and genetic processes involved in this change are still debated. Here we have used spatially explicit simulations of genomic components to better characterize the demographic and migratory conditions that may have led to this change. We investigated various scenarios representing the expansion of pastoralists from the Pontic steppe, potentially linked to the Yamnaya cultural complex, and their interactions with local populations in Central Europe, considering various eco-evolutionary factors, such as population admixture, competition and long-distance dispersal. Our results do not support direct competition but rather the cohabitation of pastoralists and farmers in Central Europe, with limited gene flow between populations. They also suggest occasional long-distance migrations accompanying the expansion of pastoralists and a demographic decline in both populations following their initial contact. These results link recent archaeological and paleogenomic observations and move further the debate of genomic changes during the early Bronze Age.
A rice QTL GS3.1 regulates grain size through metabolic-flux distribution between flavonoid and lignin metabolons without affecting stress tolerance
Authors: Zhang Yi-Min , Yu Hong-Xiao , Ye Wang-Wei , Shan Jun-Xiang , Dong Nai-Qian , Guo Tao , Kan Yi , Xiang You-Huang , Zhang Hai , Yang Yi-Bing , Li Ya-Chao , Zhao Huai-Yu , Lu Zi-Qi , Guo Shuang-Qin , Lei Jie-Jie , Liao Ben , Mu Xiao-Rui , Cao Ying-Jie , Yu Jia-Jun , Lin Hong-Xuan 
Published: October 2021

AbstractGrain size is a key component trait of grain weight and yield. Numbers of quantitative trait loci (QTLs) have been identified in various bioprocesses, but there is still little known about how metabolism-related QTLs influence grain size and yield. The current study report GS3.1, a QTL that regulates rice grain size via metabolic flux allocation between two branches of phenylpropanoid metabolism. GS3.1 encodes a MATE (multidrug and toxic compounds extrusion) transporter that regulates grain size by directing the transport of p-coumaric acid from the p-coumaric acid biosynthetic metabolon to the flavonoid biosynthetic metabolon. A natural allele of GS3.1 was identified from an African rice with enlarged grains, reduced flavonoid content and increased lignin content in the panicles. Notably, the natural allele of GS3.1 caused no alterations in other tissues and did not affect stress tolerance, revealing an ideal candidate for breeding efforts. This study uncovers insights into the regulation of grain size though metabolic-flux distribution. In this way, it supports a strategy of enhancing crop yield without introducing deleterious side effects on stress tolerance mechanisms.
Tetragonal CoMn2O4 nanocrystals on electrospun carbon fibers as high-performance battery-type supercapacitor electrode materials
Authors: Mijailović Daniel M. , Radmilović Vuk V. , Lačnjevac Uroš Č. , Stojanović Dušica B. , Bustillo Karen C. , Jović Vladimir D. , Radmilović Velimir R. , Uskoković Petar S. 
Published: October 2021

A novel C@CoMn2O4 composite material was fabricated, having improved performance as a battery-type electrode for supercapacitor applications.
Language Intervention Isn't Just Spoken: Assessment and Treatment of a Deaf Signing Child With Specific Language Impairment
Authors: Kelley Lauren E. , McCann James P. 
Published: October 2021

Purpose
This case study describes the language evaluation and treatment of a 5-year-old boy, Lucas, who is Deaf, uses American Sign Language (ASL), and presented with a language disorder despite native access to ASL and no additional diagnosis that would explain the language difficulties.

Method
Lucas participated in an evaluation where his nonverbal IQ, fine motor, and receptive/expressive language skills were assessed. Language assessment included both formal and informal evaluation procedures. Language intervention was delivered across 7 weeks through focused stimulation.

Results
Evaluation findings supported diagnosis of a language disorder unexplained by other factors. Visual analysis revealed an improvement in some behaviors targeted during intervention (i.e., number of different verbs and pronouns), but not others. In addition, descriptive analysis indicated qualitative improvement in Lucas' language production. Parent satisfaction survey results showed a high level of satisfaction with therapy progress, in addition to a belief that Lucas improved in language areas targeted.

Conclusions
This study adds to the growing body of literature that unexplained language disorders in signed languages exist and provides preliminary evidence for positive outcomes from language intervention for a Deaf signing child. The case described can inform professionals who work with Deaf signing children (e.g., speech-language pathologists, teachers of the Deaf, and parents of Deaf children) and serve as a potential starting point in evaluation and treatment of signed language disorders.

Supplemental Material

https://doi.org/10.23641/asha.16725601
Bi‐objective control design for vehicle‐mounted mobile antenna servo systems
Authors: Wen Cheng , Lu Jieying , Su Weizhou 
Published: October 2021

AbstractThis paper studies a high‐performance control design for the servo system of a vehicle‐mounted mobile satellite communication antenna. Considering the different requirements for tracking and disturbance attenuation in the servo system, a novel controller structure consisting of a central controller and a disturbance filter is proposed. Based on this controller structure, a bi‐objective control design scheme is proposed: One is an optimal tracking design for the central controller, and the other is a disturbance attenuation design for the disturbance filter. It turns out that the resulting control system achieves an optimal tracking performance when the external disturbance is at a low level; meanwhile, the system achieves a robust disturbance attenuation performance when the disturbance is significant. Moreover, considering the trade‐offs between performance and the robust stability of the closed‐loop system, the weighting parameter selection in control design criteria is studied for a practical application. Furthermore, validation experiments and field tests are carried out to evaluate the effectiveness of this design, and their results show that the well‐designed bi‐objective controller significantly improves the dynamic pointing accuracy of the antenna in tracking a geostationary satellite when its carrier is driving off‐road.
A practical de‐embedding technique based on the network theory for the filters in a 2‐channel multiplexer
Authors: Mirnaziry Sayyed Reza , Kheirdoost Ali , Haghparast Maysam , Ahmadi Ali Akbar 
Published: October 2021

AbstractA novel approach to de‐embed the frequency response of filters connected to a 2‐channel multiplexer without the need for unplugging is proposed. The technique to manifold coupled multiplexers with arbitrary number of filters is also theoretically generalised. In multiplexer tuning, there are practically important circumstances in which it is advantageous to de‐embed the frequency response of filters in multiplexers without detaching them. The authors show that using a novel technique and reasonable approximations, all filters of a multiplexer can be modelled by simple microwave networks, and then, the equivalent rational function of the channel filters can be estimated appropriately by the rational approximation; extraction of this model facilitates tuning of the filters using the coupling matrix method. The impact of mechanical tolerances on the accuracy of the proposed technique is also studied. Next, this method is examined on a 2‐channel multiplexer and its application in de‐embedding and tuning of its connected filters is verified. Provided that the mechanical tolerances of the structure are sufficiently small, this technique is a powerful engineering solution towards tuning of manifold‐coupled multiplexers.
The traditional approximation of rotation for rapidly rotating stars and planets
Authors: Dhouib H. , Prat V. , Van Reeth T. , Mathis S. 
Published: October 2021

Context. We examine the dynamics of low-frequency gravito-inertial waves (GIWs) in differentially rotating deformed radiation zones in stars and planets by generalising the traditional approximation of rotation (TAR). The TAR treatment was built on the assumptions that the star is spherical (i.e. its centrifugal deformation is neglected) and uniformly rotating. However, it has been generalised in our previous work by including the effects of the centrifugal deformation using a non-perturbative approach. In the meantime, TAR has been generalised in spherical geometry to take the differential rotation into account.
Aims. We aim to carry out a new generalisation of the TAR treatment to account for the differential rotation and the strong centrifugal deformation simultaneously.
Methods. We generalise our previous work by taking into account the differential rotation in the derivation of our complete analytical formalism that allows the study of the dynamics of GIWs in differentially and rapidly rotating stars.
Results. We derived the complete set of equations that generalises the TAR, simultaneously taking the full centrifugal acceleration and the differential rotation into account. Within the validity domain of the TAR, we derived a generalised Laplace tidal equation for the horizontal eigenfunctions and asymptotic wave periods of the GIWs, which can be used to probe the structure and dynamics of differentially rotating deformed stars with asteroseismology.
Conclusions. A new generalisation of the TAR, which simultaneously takes into account the differential rotation and the centrifugal acceleration in a non-perturbative way, was derived. This generalisation allowed us to study the detectability and the signature of the differential rotation on GIWs in rapidly rotating deformed stars and planets. We found that the effects of the differential rotation in early-type deformed stars on GIWs is theoretically largely detectable in modern space photometry using observations from Kepler and TESS.
Radioembolization of Secondary Hepatic Malignancies
Authors: Manchec Barbara , Kokabi Nima , Narayanan Govindarajan , Niekamp Andrew , Peña Constantino , Powell Alex , Schiro Brian , Gandhi Ripal 
Published: October 2021

AbstractCancer has become the leading cause of mortality in America, and the majority of patients eventually develop hepatic metastasis. As liver metastases are frequently unresectable, the value of liver-directed therapies, such as transarterial radioembolization (TARE), has become increasingly recognized as an integral component of patient management. Outcomes after radioembolization of hepatic malignancies vary not only by location of primary malignancy but also by tumor histopathology. This article reviews the outcomes of TARE for the treatment of metastatic colorectal cancer, metastatic breast cancer, and metastatic neuroendocrine tumors, as well as special considerations when treating metastatic disease with TARE.
Standard Radiation Dosimetry Models: What Interventional Radiologists Need to Know
Authors: Webster Linzi Arndt , Villalobos Alexander , Majdalany Bill S. , Bercu Zachary L. , Gandhi Ripal T. , Kokabi Nima 
Published: October 2021

AbstractThoughtful and accurate dosimetry is critical to obtain the safest and most efficacious yttrium-90 (Y90) radioembolization of primary and secondary liver cancers. Three dosimetry models are currently used in clinical practice, namely, body surface area model, medical internal radiation dose model, and the partition model. The objective of this review is to briefly outline the history behind Y90 dosimetry and the difference between the aforementioned models. When applying these three models to a single case, the differences between them are further demonstrated. Each dosimetry model in clinical practice has its own benefits and limitations. Therefore, it is incumbent upon practicing interventional radiologists to be aware of these differences to optimize treatment outcomes for their patients.
Neurologic Complications in Patients with Cancer
Authors: Holroyd Kathryn B. , Rubin Daniel B. , Vaitkevicius Henrikas 
Published: October 2021

AbstractNeurologic symptoms are commonly seen in patients with cancer and can be among the most challenging to diagnose and manage. It is often difficult to determine if new neurologic symptoms are secondary to direct effects of a malignant lesion, systemic complications of disease, paraneoplastic disorders, or side effects of cancer treatment itself. However, early diagnosis and treatment of each of these conditions can improve patients' quality of life and long-term functional outcomes. In this review, we describe a systematic approach to the diagnosis of new neurologic symptoms in patients with known malignancy. We have categorized the neurologic complications of cancer through a mechanistic approach, with an emphasis on ascertaining underlying pathophysiology to guide treatment choice. This review focuses on the acute neurologic complications of cancer that require hospital admission.
Radioembolization of Intrahepatic Cholangiocarcinoma: Patient Selection, Outcomes, and Competing Therapies
Authors: Ness Joseph Ray , Molvar Christopher 
Published: October 2021

AbstractIntrahepatic cholangiocarcinoma is the second most common primary hepatic malignancy and poses a therapeutic challenge owing to its late-stage presentation and treatment-resistant outcomes. Most patients are diagnosed with locally advanced, unresectable disease and are treated with a combination of systemic and local regional therapies. Transarterial radioembolization offers a survival benefit and a favorable side effect profile, with a growing body of evidence to support its use. Herein, we review patient selection and detail outcomes of radioembolization for intrahepatic cholangiocarcinoma, together with mention of competing treatments.
Contemporary Algorithm for the Management of Hepatocellular Carcinoma in 2021: The Northwestern Approach
Authors: Swersky Adam , Kulik Laura , Kalyan Aparna , Grace Karen , Caicedo Juan Carlos , Lewandowski Robert J. , Salem Riad 
Published: October 2021

AbstractHepatocellular carcinoma (HCC) is the most common primary liver cancer and a major cause of cancer-related morbidity and mortality around the world. Frequently, concurrent liver dysfunction and variations in tumor burden make it difficult to design effective and standardized treatment pathways. Contemporary treatment guidelines designed for an era of personalized medicine should consider these features in a more clinically meaningful way to improve outcomes for patients across the HCC spectrum. Given the heterogeneity of HCC, we propose a detailed clinical algorithm for selecting optimal treatment using an evidence-based and practical approach, incorporating liver function, tumor burden, the extent of disease, and ultimate treatment intent, with the goal of individualizing clinical decision making.
Radioembolization for the Treatment of Hepatocellular Carcinoma: The Road to Personalized Dosimetry and Ablative Practice
Authors: De la Garza-Ramos Cynthia , Toskich Beau B. 
Published: October 2021

AbstractRadioembolization dosimetry for the treatment of hepatocellular carcinoma has evolved alongside our understanding of best practice for this therapy. At the core of advances in dosimetry are personalized and ablative applications of radioembolization, which have generated paradigm shifts in both safety and efficacy. This review provides a summary of fundamental radioembolization dosimetry concepts and narrates how our approach to treating patients has shifted from conventional to tailored and definitive therapy.
Utility of 3D CT Rib Study in Presurgical Planning of Autologous Ear Graft for Pinna Reconstruction in Microtia
Authors: Zanje Sneha S. , Kamat Nikhil V. , Taware Kunal K. , Rokade M L. , Bhumkar Ashesh C. 
Published: October 2021

Abstract
Purpose The aim of this study was to demonstrate the utility of three-dimensional computed tomography (3D) CT rib study in presurgical planning to select the autologous rib cartilage graft for pinna reconstruction.
Materials and Methods Total of 35 patients of microtia for autologous rib graft from April 2017 to February 2020 were evaluated in this study. All patients had a plain low-dose multislice CT chest. The length of costal cartilages of sixth to ninth ribs bilaterally and width and height of sixth and seventh rib costal cartilage synchondrosis were measured in 3D reconstructed true size coronal images with best possible length displayed. All patients had high-resolution computed tomography (HRCT) temporal studies done to evaluate for associated anomalies in external canal, middle ear cavities, and inner ear structures. Eleven patients had simultaneous HRCT temporal bone done after plain CT chest and rest who had done recent prior study were reviewed without repetition of study.
Results There were 19 males and 16 females for 3D CT rib study. Average age of the participants was 16.5 years. The average width of synchondrosis of sixth and seventh rib was 15.4 mm on right side and 14.7 mm on left side, average height of synchondrosis was 28.5 mm on right side and 30.7 mm on left side. Average length of the eighth rib costal cartilage was 88.6 mm on the right side and 90.5 mm on the left side. Average length of the ninth rib was 63.2 mm on the right side and 58.2 mm on the left side. Costal cartilage calcifications were present in 9 patients.
Conclusion Preoperative 3D CT rib study provides accurate measurements of rib stock for sculpting autologous ear graft.
Hypertrophic Cardiomyopathy with a Twist
Authors: Francis W. , Alkuwari M. E. , Mohiaddin R. , Carr C. S. 
Published: October 2021

AbstractHypertrophic cardiomyopathy is a relatively common inherited cardiac disorder, with echocardiography still being the initial imaging method for its diagnosis. Cardiac fibroma is a primary neoplasm that most commonly presents in childhood. We present a patient who was investigated for typical cardiac symptoms who went on to have cardiac magnetic resonance imaging and was found to have both of these conditions.
Follicular Cholecystitis Mimicking Xanthogranulomatous Cholecystitis and Malignancy: A Case Report
Authors: Aineseder Martina , Grove Roy López , Mullenl Eduardo G. , Spina Juan C. 
Published: October 2021

AbstractChronic follicular cholecystitis (CFC) is a rare pathology characterized by prominent lymphoid follicles in the lamina propria distributed throughout the gallbladder wall. It has also been mentioned in the literature as lymphoid hyperplasia and pseudolymphoma. CFC represents less than 2% of cholecystectomies. Its etiopathology is mostly unknown. Most reports are based on histopathological findings, with little or no imaging analysis. We describe a case involving a 66-year-old man radiologically diagnosed as xanthogranulomatous cholecystitis (XGC) versus malignancy, revealing CFC with surrounding inflammatory changes in the cholecystectomy specimen.