bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective influence of cyflumetofen in degradation and ecological risk assessment
Authors: Shi Linlin , Zhang Ping , Chen Qi , Yang Cancan , Zhang Daqi , Xu Jun , He Lin 
Published: August 2021

AbstractPesticide pollution has gradually caused land degradation. In order to avoid this problem, it is recommended to use enantiomeric pesticides that have less impact on the soil. Cyflumetofen's (CYF) microecological environmental assessment at the enantiomer level is unclear. In our study, the degradation of CYF enantiomers and the effect on soil functions are closely related to microorganisms. (+)‐CYF enantiomer is degradable preferred and further discovered that related microorganism that degrades enantiomers. CYF enantiomers alter the bacteria structure and decreased the bacteria abundance. The combination of high‐throughput and quantitative PCR results showed that the diversity of the (+)‐CYF treatment was significantly lower than that of the (−)‐CYF (−30.41 to 44.60) treatment, and the (+)‐CYF treatment (−27.80% to 56.70%) was more capable of causing the decrease in the number of soil microorganisms. In addition, (+)‐CYF severely interferes with nitrogen cycling–related functions. Furthermore, the soil microbial structure was changed to its original level by enantiomers posed. In the study of nitrogen cycle functions, we found that both enantiomers can restrain the abundance of nitrogen cycle–related genes, especially the (+)‐CYF treatment decreased more. Canonical correspondence analysis (CCA) showed that g‐Massilia and g‐Arthrobacter are closely related to nitrogen fixation genes and nitrification genes, and degradation of the two enantiomers of CYF by g‐Arthrobacter is closely related. The biological effects of CYF enantiomers remain unclear. Bioassay results show that enantiomers have similar virulence to Tetranychus cinnabarinus. Therefore, while achieving the prevention and control effect, the use of a single isomer (+)‐CYF has a higher potential risk to the soil ecosystem.
Spatial microheterogeneity and selective microbial consumption of dissolved free amino acids in an oligomesotrophic lake
Authors: Krempaska Natalia , Hornˇák Karel , Silva Marisa O.D. , Pernthaler Jakob 
Published: August 2021

AbstractWe studied the cm to m scale spatial distribution of dissolved free amino acids (DFAA) in the upper epilimnion of oligomesotrophic Lake Zurich in 14 sampling campaigns over > 3 years and at various periods of the growing season. During each campaign, 10 sets of 10 simultaneously drawn samples (10 mL, 2 cm distance) were collected from 5 m depth. DFAA concentrations varied by one to > 3 orders of magnitude within sets, providing field evidence for DFAA release from macroscopic point sources and for substantial variability of the in‐situ growth conditions of bacterioplankton metacommunities. There was a tight relationship between the median DFAA concentration per sampling campaign and the compositional heterogeneity of the 15 most common AA: their composition was similar in samples from campaigns with high median DFAA concentrations, indicating that spatial distribution patterns were mainly a result of physical mixing. By contrast, AA composition was spatially variable in campaigns with low median DFAA concentrations, and serine, aspartate, and glycine were disproportionally high in the 10% samples with highest DFAA concentrations. We hypothesized that pelagic bacteria would preferably target pulses of such locally overrepresented AA. Short‐term incubations with radiolabeled tracers revealed substantially higher microbial uptake of serine and, to a lesser extent, aspartate, than of two amino acids with consistently low in situ concentrations (leucine, isoleucine). This illustrates a “preparedness” of the bacterioplankton to preferably incorporate those AAs that are more available in DFAA hotspots.
The nuclear trace of periodic vector‐valued pseudo‐differential operators with applications to index theory
Authors: Cardona Duván , Kumar Vishvesh 
Published: August 2021

AbstractIn this paper we investigate the nuclear trace of vector‐valued Fourier multipliers on the torus and its applications to the index theory of periodic pseudo‐differential operators. First we characterise the nuclearity of pseudo‐differential operators acting on Bochner integrable functions. In this regards, we consider the periodic and the discrete cases. We go on to address the problem of finding sharp sufficient conditions for the nuclearity of vector‐valued Fourier multipliers on the torus. We end our investigation with two index formulae. First, we express the index of a vector‐valued Fourier multiplier in terms of its operator‐valued symbol and then we use this formula for expressing the index of certain elliptic operators belonging to periodic Hörmander classes.
Mapping afferent and pelvic postganglionic neurons of the urethra from female rats: The L6 DRG is the major primary afferent supplier
Authors: Mirto‐Aguilar Nancy , Morán Carolina , Díaz Alfonso , Cruz Yolanda 
Published: August 2021

AbstractAimsTo map sensory and pelvic postganglionic neurons from three different regions of the female rat urethra.MethodsThe neuronal tracer True Blue (TB) was injected into the pre‐pelvic, pelvic, and clitoral regions of the urethra from female Wistar rats. Seven days after TB injection, TB+ cells from the dorsal root ganglia (DRGs) and the major pelvic ganglion (MPG) were examined. The number and morphometry of TB+ cells were determined.ResultsTB+ cells were mainly distributed in lumbar 1 (L1), lumbar 2 (L2), lumbar 6 (L6), and sacral 1 (S1) DRGs, and in the MPG. The mean number of sensory neurons was 1200 ± 143. TB injection in pre‐pelvic and pelvic urethra labeled neurons in L1, L2, L6, and S1 DRGs. TB injection in clitoral urethra labeled neurons in L6 and S1 DRGs. L6 DRG contained >50% of the total urethral TB+ neurons, and ~80% of the clitoral region. The mean value of the total number of MPG TB+ neurons was 1217 ± 72. DRG and MPG neurons projecting to the urethra presented a somatotopic distribution.ConclusionsThe results demonstrated that L6 DRG is the major supplier of afferent innervation to the urethra, and that the distal urethral region is exclusively innervated by lower lumbosacral DRGs. Considering that electrical stimulation of sensory pudendal nerve improves overactive bladder, and that most of the sensory neurons in the distal urethra are from L6 DRG, electrical stimulation of this ganglion may be an innovative and effective neuromodulation therapy for neurogenic urinary dysfunctions.
Pilot randomized controlled trial of a hypnosis intervention for women with bladder pain syndrome
Authors: Soriano Alex J. , Schnur Julie B. , Harvie Heidi S. , Newman Diane K. , Montgomery Guy H. , Arya Lily A. 
Published: August 2021

AbstractAimsTo evaluate the feasibility and acceptability of a randomized controlled trial of a hypnosis intervention for the treatment of bladder pain syndrome/interstitial cystitis (BPS/IC) in women.MethodsWe conducted a parallel arm, non‐blinded, pilot randomized controlled trial of standardized hypnosis sessions including a hypnosis web tool versus usual care in adult women with BPS/IC. Pilot study outcomes included feasibility domains: process, resources and management, safety, and acceptability. Clinical outcomes of lower urinary tract symptoms and quality of life were measured using validated questionnaires at baseline and at the end of the 4‐week intervention.ResultsWe randomized 29 out of 30 (96.7%) eligible women. In the hypnosis group, 12 of 15 (80.0%) subjects completed the 4‐week intervention and follow up, and 13 of 14 (92.9%) in the usual care group. In the hypnosis group, adherence to the standardized sessions was 80% and participants used the web‐based tool for an average of 5.6 ± 2.7 times per week. Scores for emotional distress, relaxation, pain severity and expected bladder symptoms significantly improved during the first two of three planned hypnosis sessions (all p < 0.05). Improvement in quality of life scores was greater in the hypnosis group than the usual care group (−2.6 ± 2.3 vs. −0.9 ± 1.1, p = 0.04). There were no significant between‐group differences in urinary symptoms or bladder pain. No adverse events were reported.ConclusionsA hypnosis intervention for the treatment of bladder pain syndrome/interstitial cystitis is feasible, acceptable, safe, and may improve quality of life.
Urodynamics criteria of detrusor underactivity in women underwent middle urethral sling for stress urinary incontinence: What is the clinical role?
Authors: Rubilotta Emanuele , Balzarro Matteo , Gubbiotti Marilena , Cerrato Clara , Giannantoni Antonella , Antonelli Alessandro 
Published: August 2021

AbstractAimsTo assess the role of detrusor underactivity (DUA), diagnosed by different urodynamic criteria, on outcomes of women underwent middle urethral sling (MUS) for stress urinary incontinence (SUI).MethodsIn this prospective study, DUA criteria of women with SUI, naïve for SUI surgery, candidates to MUS were:I Pdet@Qmax ≤10 cm H2O and Qmax ≤12 mL/s (Jeong et al.)ii Pdet@Qmax<30 cm H2O and Qmax<10 mL/s (Abarbanel and Marcus)iii Pdet@Qmax<20 cm H2O and Qmax<15 mL/s and BVE < 90% (BVE criteria) iv Pdet@Qmax<20 cm H2O + Qmax (PIP1 Griffiths)Control group (CG) comprised non‐DUA patients. Preoperative and at 2‐years follow‐up evaluation included physical examination, uroflowmetry, post void residual urine (PVR), ICIQ‐FLUTS.Results102 patients fulfilled 2‐years controls. DUA rate range was 16.7% (BVE) − 53.9% (PIP1‐Griffith). The POUR rate varied: 20% (PIP1‐Griffith) − 35.3% (BVE), 10% in CG. Tape incision rate for POUR was 3.4% in DUA, 4.5% in CG. No patients had urinary retention at 2‐years follow‐up. In DUA groups, Qmax did not change significantly after surgery and PVR was low. SUI recurrence rate was 2.8% in DUA, 4.5% in CG. Preoperatively, urgency and post‐micturition dribble were the most (82.4%) and the less (26.7%) reported symptoms, respectively. At follow‐up, frequency was the most prevalent (56.1%), reduced sensation/bladder pain the less usual (23.1%). ICIQ‐FLUTS scores were higher in DUA groups.ConclusionsDUA did not have a negative impact on MUS outcomes in a mid‐term follow‐up. Early postoperative voiding complication rates changed according to the type of DUA urodynamic criteria.
Polyamide nanocomposites containing hydrazide–hydrazone group reinforced with functionalized polyethyleneimine modified Mg(OH)2 nanoparticles: Study on thermal properties, combustion resistance, and lead ion adsorption
Authors: Hajibeygi Mohsen , Faramarzinia Shayan 
Published: August 2021

AbstractPolyamide nanocomposites (PANC) were prepared from an aliphatic–aromatic polyamide (PA) containing hydrazide–hydrazone groups in the side chain, reinforced with functionalized polyethyleneimine (FPEI)/modified Mg(OH)2 nanoparticles (FPMN). For this purpose, a new structure, aromatic diamine (DAHH), containing the hydrazide–hydrazone group, was synthesized, and used to synthesize PA by direct polycondensation. Also, polyethyleneimine (PEI) was structurally modified with salicylaldehyde for the modification of the surface of Mg(OH)2 nanoparticles (MDH). The Field‐Emission Scanning Electron Microscopy and X‐ray diffraction results revealed that MDH were uniformly dispersed in nano‐size in the PA matrix. The thermogravimetric analysis results in both N2 and air environments showed that PANC possesses higher thermal resistance than that of the neat PA. The 5% degradation temperature (T5) of PANC containing 8 wt% of FPMN was obtained 40°C more than that of the pure PA in the N2 environment. The microscale combustion calorimetry (MCC) results exhibited that the loading of FPMN into the PA matrix can efficiently increase the combustion resistance by decreasing the MCC parameters such as the heat release rate values. In addition, the lead ions adsorption efficiency of the prepared nanostructure materials was investigated, and the results exhibited that the adsorption data were obtained following the Langmuir isotherm model. The maximum adsorption efficiency was calculated to be 99.96% for PANC 8.
Insulin NPH for steroid‐induced hyperglycemia: Predictors for success
Authors: Stone Andrew C. , Dungan Kathleen , Gaborcik Joshua W. 
Published: August 2021

AbstractStudy ObjectiveThis study aimed to evaluate the efficacy of insulin neutral protamine Hagedorn (NPH) for steroid‐induced hyperglycemia and identify factors associated with achievement of euglycemia.DesignRetrospective, single center, cohort analysis.SettingQuaternary care academic medical center.PatientsAdult patients with steroid‐induced hyperglycemia on combination therapy of an intermediate‐acting steroid and once daily NPH.InterventionThe primary outcome was the percentage of patients who achieved euglycemia on day 3 of combination therapy. Patients were divided into euglycemic and dysglycemic cohorts based on the primary outcome. Univariate analysis on baseline characteristics, NPH dose, and steroid dose based on prednisone equivalent dose (PED) was conducted to identify differences between the cohorts. Safety analysis was conducted to detect differences between the two cohorts.Measurements and Main ResultsOf 142 patients included in the primary analysis, 50 (35.2%) achieved euglycemia on day 3 of combination therapy. In univariate analysis, patients who achieved euglycemia had significantly higher median NPH dose standardized to steroid dose on day 1 (0.5 units/mg PED [25%–75% interquartile range (IQR) 0.4–0.8] vs 0.4 units/mg PED [0.2–0.8]; p = 0.046), lower median blood glucose prior to combination therapy on day 3 (111 mg/dl [96–160] vs 136 mg/dl [113–198]; p = 0.008), and lower median blood glucose 4 hours after administration of combination therapy on day 3 (147 mg/dl [116–197] vs 190 mg/dl [153–245]; p = 0.003) compared to patients who did not achieve euglycemia, respectively. Hypoglycemia and life‐threatening hypoglycemia occurred at similar rates between the two cohorts.ConclusionsNeutral protamine Hagedorn is a safe and efficacious option for acute care hospitalized patients experiencing steroid‐induced hyperglycemia. More aggressive dosing initiation of NPH based on steroid dose may allow for earlier achievement of euglycemia without a difference in hypoglycemia.
Synthesis and photoluminescence properties of fluorine‐containing poly(phenylene vinylene) bearing hexafluorocyclopentene‐fused phenanthrene unit
Authors: Fukumoto Hiroki , Shiitsuka Kazuki , Yamada Keisuke , Yamada Shigeyuki , Konno Tsutomu , Kubota Toshio , Agou Tomohiro 
Published: August 2021

AbstractThe intramolecular oxidative photocyclization of 1,2‐diarylhexafluorocyclopentene (1) under light irradiation (λ = 365 nm) provided hexafluorocyclopentene‐fused phenanthrene with formyl groups (2) in moderate yield. The copolymerization of 2 with tetraethyl(2,5‐bis(dodecyloxy)‐1,4‐phenylene)bis(methylene)diphosphonate by the Horner–Wadsworth–Emmons reaction gave a fluorine‐containing poly(phenylene vinylene), Polymer‐2, in 41% yield. For comparison, a diphenylethene‐type copolymer, Polymer‐1, was also prepared analogously. The number‐average molecular weights of Polymer‐1 and Polymer‐2 were 8900 and 3300 g mol−1, respectively. The copolymers showed high thermal stability, as revealed by their thermogravimetric analysis. UV–visible spectra of the copolymers in CHCl3 showed π–π* transition peaks at around 420 nm, and the peaks shifted to longer wavelengths by ca 10 nm for samples in film form. The photoluminescence spectra of Polymer‐1 and Polymer‐2 exhibited peaks at 542 and 560 nm in CHCl3, respectively, whereas the photoluminescence intensity of Polymer‐2 was very low in the solid state, presumably owing to the partial aggregation of the polymer molecules. © 2021 Society of Industrial Chemistry.
Negative pressure pulmonary oedema due to rigors and chills associated with liver abscess
Authors: Chaudhry Haroon , Nimmala Swathi , Papudesi Bhavani Nagendra , Sajjad Fizza , Paul Sanu , Gohar Zimran , Azad Reuben , Naveen Hannah , Demidovich Joseph 
Published: August 2021

AbstractA 61‐year‐old male presented with progressive generalized weakness, myalgia, diaphoresis, fever, episodic chills and rigors that had started 4 days previously. Chest x‐ray (CXR) showed overlying curvilinear radio‐opacities. Abdominal computed tomography revealed liver and bilateral adrenal lesions. Empiric 7‐day intravenous Piperacillin / Tazobactam (Zosyn) was initiated, and he was admitted for sepsis. After an episode of rigors on Day 2, he developed acute hypoxic respiratory failure with inspiratory stridor. CXR revealed new, bilateral airspace disease. Racemic Epinephrine, Solumedrol, Ketorolac (Toradol) and Diphenhydramine were given, and he was transferred to the intensive care unit with presumptive diagnosis of foreign body aspiration or allergic reaction. With each subsequent episode of rigor and chills, he continued developing hypoxic respiratory failure with stridor and an incremental increase in pulmonary oedema on imaging. Pulmonologist concluded it likely secondary to negative pressure pulmonary oedema caused by transient laryngeal dyskinesia induced by the increased work of breathing associated with rigors. Symptoms resolved after the complete course of antibiotics along with supportive therapy.
Clinicopathological characteristics and imaging findings to identify adenomyosis‐related symptoms
Authors: Imanaka Shogo , Shigetomi Hiroshi , Kawahara Naoki , Kobayashi Hiroshi 
Published: August 2021

AbstractPurposeThe study aims to identify the clinicopathological risk factors and magnetic resonance (MR) imaging findings for adenomyosis‐related symptoms, including menorrhagia, dysmenorrhea, and infertility.MethodsThis was an observation‐based cross‐sectional study using data from the adenomyosis cohort study. The authors evaluated the clinicopathological variables and various MR imaging findings.ResultsTwo hundred twenty patients with histologically confirmed adenomyosis were included in this study. Multivariate analysis showed that a middle/retroflexed uterus and adenomyosis lesions of 21 mm or more were significant independent predictors of dysmenorrhea. The history of dysmenorrhea and the maximum length from the cervix to the uterine fundus ≥103 mm were independent risk factors of menorrhagia. One of the key factors associated with non‐infertility included the absence of deep infiltrating endometriosis (DIE) and/or superficial peritoneal disease (SUP).ConclusionsThis study identified clinicopathological risk factors and imaging findings associated with adenomyosis‐related symptoms. The maximum length from the cervix to the uterine fundus and adenomyosis lesion thickness are independent predictors for the presence of menorrhagia and dysmenorrhea, respectively. Infertility may be associated with the coexistence of endometriosis rather than adenomyosis itself. This result is from an analysis of a small number of infertility patients and requires further study.
Variable‐geometry exit nozzle for improving static thrust of drones ducted fans
Authors: Corva Dean M. , Adams Scott D. , Kouzani Abbas Z. 
Published: August 2021

AbstractUnmanned aerial vehicles, or drones, are a technology that has seen rapid growth. Their ability to offload tasks that are once considered labor intensive is one of their many appealing aspects. This aspect increases time for tasks of higher importance, meaning reliance on this technology is ever increasing. These tasks include land geo‐mapping, firefighting, surveillance, delivery services, search and rescue among others. As with every growing technology, however, comes the negative exposure, shadowing further expansion and growth. For drones, this includes noise pollution, and hazardous, low efficiency propulsion systems. Regulations and laws are beginning to surface, regulating the use of drones and their noise levels within airspace, as future growth can overcrowd airspace. Current drones use propulsion systems that expose the public to hazardous propellers and high levels of noise, thus unsuitable for their expected growth. This paper presents a novel variable‐geometry exit nozzle to improve the efficiency of current propulsion systems in drones, in turn reducing noise levels and hazards, that are currently foreshadowing drones. The presented propulsion method achieves results that show better performance than a ducted fan and propeller under static conditions. Three experiments are conducted, and the results are reported and discussed.
Dataset Sensitive Autotuning of Multi-versioned Code Based on Monotonic Properties
Authors: Munksgaard Philip , Breddam Svend Lund , Henriksen Troels , Gieseke Fabian Cristian , Oancea Cosmin 
Published: August 2021

AbstractFunctional languages allow rewrite-rule systems that aggressively generate a multitude of semantically-equivalent but differently-optimized code versions. In the context of GPGPU execution, this paper addresses the important question of how to compose these code versions into a single program that (near-)optimally discriminates them across different datasets. Rather than aiming at a general autotuning framework reliant on stochastic search, we argue that in some cases, a more effective solution can be obtained by customizing the tuning strategy for the compiler transformation producing the code versions.We present a simple and highly-composable strategy which requires that the (dynamic) program property used to discriminate between code versions conforms with a certain monotonicity assumption. Assuming the monotonicity assumption holds, our strategy guarantees that if an optimal solution exists it will be found. If an optimal solution doesn’t exist, our strategy produces human tractable and deterministic results that provide insights into what went wrong and how it can be fixed.We apply our tuning strategy to the incremental-flattening transformation supported by the publicly-available Futhark compiler and compare with a previous black-box tuning solution that uses the popular OpenTuner library. We demonstrate the feasibility of our solution on a set of standard datasets of real-world applications and public benchmark suites, such as Rodinia and FinPar. We show that our approach shortens the tuning time by a factor of $$6\times $$

6
×

on average, and more importantly, in five out of eleven cases, it produces programs that are (as high as $$10\times $$

10
×

) faster than the ones produced by the OpenTuner-based technique.
A look into retinal organoids: methods, analytical techniques, and applications
Authors: Afanasyeva Tess A. V. , Corral-Serrano Julio C. , Garanto Alejandro , Roepman Ronald , Cheetham Michael E. , Collin Rob W. J. 
Published: August 2021

AbstractInherited retinal diseases (IRDs) cause progressive loss of light-sensitive photoreceptors in the eye and can lead to blindness. Gene-based therapies for IRDs have shown remarkable progress in the past decade, but the vast majority of forms remain untreatable. In the era of personalised medicine, induced pluripotent stem cells (iPSCs) emerge as a valuable system for cell replacement and to model IRD because they retain the specific patient genome and can differentiate into any adult cell type. Three-dimensional (3D) iPSCs-derived retina-like tissue called retinal organoid contains all major retina-specific cell types: amacrine, bipolar, horizontal, retinal ganglion cells, Müller glia, as well as rod and cone photoreceptors. Here, we describe the main applications of retinal organoids and provide a comprehensive overview of the state-of-art analysis methods that apply to this model system. Finally, we will discuss the outlook for improvements that would bring the cellular model a step closer to become an established system in research and treatment development of IRDs.