bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of native endophytic bacteria on the growth and bacterial crown rot tolerance of papaya (Carica papaya)
Authors: Rivarez Mark Paul Selda , Parac Elizabeth P. , Dimasingkil Shajara Fatima M. , Mirnia Eka , Magdalita Pablito M. 
Published: May 2021

Abstract
The native plant microbiome is composed of diverse communities that influence its overall health, with some species known to promote plant growth and pathogen resistance. Here, we show the antibacterial and growth promoting activities of autoclaved culture metabolites (ACMs) from native endophytic bacteria (NEB) in a papaya cultivar that is tolerant to bacterial crown rot (BCR) caused by Erwinia mallotivora . Initially, bacterial colonization in recovering tissues of this cultivar was observed before onset of tissue regeneration or 'regrowth'. We further isolated and characterized these bacteria and were able to identify two culturable stem NEB under genera Kosakonia (EBW), related to Enterobacter , and Sphingomonas (EBY). We also identified root NEB (BN, BS and BT) under genus Bacillus . Inhibition assays indicated that ACMs from these NEB promptly (18-30h) and efficiently inhibited (60-65%) E. mallotivora proliferation in vitro. Interestingly, when ACMs from BN and EBW were inoculated in surface-sterilized papaya seeds, germination was variably retarded (20-60% reduction) depending on plant genotype, but plant biomass accumulation was significantly stimulated, at around two-fold increase. Moreover, greenhouse experiments show that ACMs from all isolates, especially EBW, significantly reduced BCR incidence and severity in susceptible genotype, at around two-fold. In general, our observations of pathogen antagonism, plant growth promotion leading to disease reduction by ACMs of native endophytic bacteria suggested its contribution to increased fitness of papaya and tolerance against the (re)emerging BCR disease.
ACP5, TNF, and MMP8 were identified as potential biomarkers of steroid-induced osteonecrosis of the femoral head
Authors: Zhang Jian , Liu Zehan , Ren Shuai , Shen Zilong , Han Kecheng , Xin Weiguang , He Guanyi , Huang Chi , Liu Jianyu 
Published: May 2021

Abstract
Steroid-induced osteonecrosis of the femoral head (SONFH) is a progressive bone disorder that is characterized by femoral head collapse and hip joint dysfunction. To elucidate the biomarkers of SONFH, the GSE123568 dataset was downloaded from the Gene Expression Omnibus (GEO) database. A total of 436 differentially expressed SONFH genes were screened in comparison with non-SONFH genes. Six biological processes and four KEGG pathways were enriched in SONFH by GSEA, and 68 candidate genes that were involved in these pathways were selected for subsequent analysis. Moreover, through an ingenuity pathway analysis, we obtained 10 canonical pathways and 20 molecule function modules related to SONFH, and acquired 121 candidate genes. Furthermore, we identified ACP5, TNF, and MMP8 as the genes most related to SONFH according to the VarElect and MalaCards database. Based on these hub genes, the targeted miRNAs and the lncRNAs were predicted. Finally, the ceRNA network was constructed by using ACP5, TNF, MMP8, seven miRNAs, and 956 candidate lncRNAs. In conclusion, the ACP5, TNF, and MMP8 might be potential biomarkers of SONFH.
VARIASI PENAMBAHAN SIKACIM PADA BETON POROUS
Authors: Gusneli Yanti  , Zainuri  , Shanti Wahyuni Megasari  
Published: May 2021

Beton porous merupakan beton ramah lingkungan karena mempunyai rongga saling terhubung yang menghasilkan bahan yang permeabel, sehingga memungkinkan dapat mengalirkan air secara cepat dan dapat mengurangi limpasan. Beton ini dapat diaplikasikan untuk area parkir, trotoar untuk pejalan kaki dan sebagainya. Tujuan dari penelitian ini untuk mengetahui karakterisitk beton dengan pengamatan terhadap kuat tekan dan porositasnya. Metode yang digunakan adalah experimen dengan sampel uji berbentuk silinder ukuran 150 x 300 mm. Pada penelitian ini menggunakan agregat kasar, semen, air serta variasi penambahan admixture SikaCim concrete additive sebesar 0% (kontrol); 0.3 % ; 0.5%; 0.7% terhadap berat semen. Fas yang dipergunakan sebesar 0.25 dan 0.30 serta perbandingan semen dan agregat kasar 1:3 dan 1:5. Hasil penelitian menunjukkan nilai kekuatan tekan beton porous mengalami kenaikan seiring dengan semakin kecil nilai rasio semen agregat. Nilai porositas beton porous dengan fas 0.25 lebih tinggi dari fas 0.30 Terdapat hubungan antara porositas dan kuat tekan, kekuatan tekan umumnya meningkat seiring dengan penurunan porositas. Nilai rata-rata kuat tekan tertinggi dengan variasi penambahan SikaCim sebesar 0.5% dan perbandingan semen agregat kasar 1:3 serta faktor air semen 0.3, dengan nilai kuat tekan sebesar 18.08 MPa, termasuk dalam kategori B yang digunakan untuk pelataran parkir.
Research in the Field of Enterprise Management
Authors: Shakhriyor Mukhamаdzhanov 
Published: May 2021

Abstract
The need for a competitive enterprise to comply with the requirements of a market economy obliges it to constantly improve both technologically and organisationally. The basis of organisational innovation is the study of organisation management systems – activities aimed at the development and improvement of management in accordance with constantly changing external and internal conditions. Improving the management of modern dynamically developing enterprises, as socio-technical systems, requires the study of their properties, which is associated with solving the problem of performing research at a high scientific and methodological level. The article is devoted to the principles, methods and problems of these studies.
New Distribution Data for Prussian Carp Carassius gibelio (Bloch 1782) in the Middle Black Sea Region of Turkey
Authors: Yedier Serdar , Bostanci Derya , Polat Nazmi 
Published: May 2021

Abstract
In this study, the new occurrence of Carassius gibelio belonging to the genus Carassius in Ulugöl Plateau Pond (Mesudiye-Ordu, Turkey) and Perşembe Plateau Pond (Aybastı-Ordu, Turkey) in the Middle Black Sea Region (Turkey) is reported. The distribution data of Prussian carp was updated in the Middle Black Sea Region of Turkey in comparison to the previously known data. Presenting morphological data of samples collected from two different areas in the Middle Black Sea Region may contribute to revealing the current distribution status of this invasive species and determining the potential distribution areas.
Optimization in Water Resources At Dry Weather Conditions Before and After the Dam Failure By Using Dummy Variable Regression Approach
Authors: Torabi H. A. , Najarchi M. , Mazaheri H. , Jafarinia R. , Izadikhah M. 
Published: May 2021

Abstract
One of the direct economic consequences of dam failure (DF) is that water supply for irrigation is affected and incomes of the agriculture sector (AS) are reduced. The main purpose of this study is to apply a linear programming model (LPM), which, the objective function of the model was set to maximize the income function of the region AS with accessible water sources and function of crops production before and after the DF by using dummy variable (DV) regression models to optimize water supply for irrigation. The results obtained indicate that the consumption of surface water(SW) and groundwaters (GW), before the DF has not been optimized, as there are 15.5 % source loss in SW and 14.5 % in GW. After the DF, the allocation of SW in the best possible situation of access to SW sources is independent of the model input. It has a fixed value equivalent to 86 million cubic meters (MCM), which indicates a 116% decrease in comparison with the optimized value. Total accessible water sources are decreased by 36 % and using GW is 15 % more than an average long period time. A based on the finding from this research and its comparison with previous studies, this model is appropriate for water supply programming after DF and for dry weather Conditions.
Caracterización molecular de genes de resistencia a β-lactámicos en aislados bacterianos clínicos de la familia Enterobacteriaceae
Authors: Yauri Bucheli María Fernanda 
Published: May 2021

Las infecciones desarrolladas por enterobacterias productoras de β-lactamasas de espectro extendido (BLEE) se relacionan a altas tasas de mortalidad y morbilidad en ambientes hospitalarios debido a su capacidad de hidrolizar antibióticos β-lactámicos. El objetivo de este estudio fue caracterizar los genes que confieren resistencia a β-lactámicos en enterobacterias obtenidas de un hospital de tercer nivel de la ciudad de Quito. Se colectaron 153 enterobacterias y se identificó la especie con pruebas bioquímicas. El estudio seleccionó los aislados que presentaron producción de enzimas BLEE analizado por el método de sinergia de doble disco y el sistema automatizado VITEK 2 proporcionado por el centro hospitalario. De los 22 aislados seleccionados, 19 fueron identificados como Escherichia coli y 3 como Klebsiella oxytoca. La capacidad de los aislados de producir enzimas carbapanemasas se determinó con Triton Hodge Test (THT), demostrando que ningún aislado tenía esta capacidad. La identificación de genes de resistencia empleó reacción en cadena de la polimerasa y usó cebadores específicos de cada gen codificante de BLEE (blaCTX-M, blaTEM, blaSHV) y de enzimas carbapenemasas (blaKPC, blaIMP, blaVIM, blaNDM). La identificación de la variante alélica reportó que 11/22 aislados presentaron el gen blaCTX-M-15 y 4/22 el gen blaTEM-1. Ninguno aislado presentó genes de resistencia a carbapenems.

PALABRAS CLAVES: β-lactamasas de espectro extendido (BLEE), enterobacterias, genes de resistencia, resistencia bacteriana, variante alélica.
Service Learning to Increase Utilization of X Video Editing Software Features within Limited Facilities for the Youth of Gereja Kristen Pasundan Cideres
Authors: Yapinus Pin Panji , Karsten Leon , Bayu P. Emmanuel F. Sigit , Kesumah Gilberth Giandy Taruna , Parera Rudianov Z.A. , Anderson Richard 
Published: May 2021

The service learning in multimedia skills for teenagers and young people as training program for the community was conducted through the expertise of Bachelor Program in Computer Engineering, Faculty of Engineering, Universitas Kristen Maranatha, for Gereja Kristen Pasundan (GKP) Cideres. The purpose of this training was to equip people with skills or knowledge that can be useful in daily activities. As this training was given during the Covid-19 pandemic, by requirement of health and safety protocols, the service learning was implemented online via the internet in a form of webinar. Online digital activities are increasingly important as conventional physical interactions and communication in work or study environment become unsafe and to be avoided or to be done less often than usual. Unfortunately for most people, technical skills for working or studying online are not yet adequate, especially in multimedia using some recent tools and softwares. So in this program, basic multimedia producing skills using Microsoft Photos (video editing feature) and Microsoft Power Point were introduced. The end result of the training was satisfactory, as those who participate are being able to produce simple digital multimedia presentation using the aforementioned tools and softwares. The training program was held online on November 28th, 2020 via Zoom Meeting Application, and was made possible thanks to the collaboration of Bachelor Program in Computer Engineering with the Directorate of Student and Alumni Affairs, Universitas Kristen Maranatha.
Keywords: Covid-19 pandemic; multimedia; service learning
El concepto de culpa desde los principales referentes de la filosofía contemporánea
Authors: Aguilar-Gordón Floralba , Batallas-Almeida Karol 
Published: May 2021

El manuscrito discute sobre el concepto de culpa desde Nietzsche, Heidegger, Jaspers y Ricouer como principales referentes de la filosofía contemporánea que han abordado este tema. En el artículo se reflexiona acerca de las distintas concepciones de culpa y su relación con el sujeto moderno, su existencia, la trascendencia y la responsabilidad. En una época tecnificada, dominada por la tendencia utilitarista y consumista, la producción en serie y la enajenación que vive el ser humano respecto a sí mismo, se hace indispensable repensar en torno a la autenticidad, a la individualidad y a la subjetividad en contextos singulares como el nuestro. La metodología utilizada para la estructuración de este documento se respalda en las principales directrices de la investigación cualitativa, se apoya en la revisión bibliográfica, el análisis de textos, y consecuentemente, el método hermenéutico para la interpretación de las teorías, categorías, principios, doctrinas y concepciones. El artículo se encuentra estructurado en cuatro apartados: El primer apartado presenta una discusión sobre el concepto de culpa y el nacimiento de la conciencia desde la perspectiva nietzscheana. El segundo apartado se refiere al concepto de culpa en la filosofía de Martín Heidegger, explica la función que cumple la culpa en el esclarecimiento del sentido del ser. El tercer apartado realiza una exposición sobre la relación entre el concepto de culpa y trascendencia según Karl Jaspers. Finalmente, el cuarto apartado, indaga sobre la relación planteada por Ricouer acerca del concepto de culpa y la responsabilidad.
Dampak Reward dan Punishment dalam Membentuk Disiplin Anak Usia 5-6 Tahun Pada Masa BDR (Belajar Dari Rumah) di Tk Putra 1 Mataram
Authors: Irwan Irwan , Hully Hully , Ulfa Mariana 
Published: May 2021

Salah satu bentuk pengembangan nilai pendidikan karakter pada anak yang dapat membentuk perilaku positif adalah dengan penanaman nilai karakter disiplin. Penelitian ini bertjuan untuk memperoleh data mengenai dampak reward dan punishment dalam membentuk disiplin anak usia 5-6 Tahun pada masa BDR (Belajar Dari Rumah) di TK Putra 1 Mataram. Dalam membentuk disiplin anak usia 5-6 tahun guru di TK Putra 1 Mataram menggunakan metode reward dan punishment. Reward merupakan hadiah, penghargaan yang dijadikan sebagai alat pendidikan dan diberikan ketika anak melakukan hal positif dan mengerjakan sesuatu dengan baik. Sedangkan, punishment yaitu hukuman yang diberikan kepada anak yang melakukan pelanggaran dengan tujuan agar anak merasa jera dan mau memperbaiki kesalahan yang diperbuatnya. Jenis penelitan ini menggunakan pendekatan kualitatif deskriftif dengan fokus penelitian dampak reward dan punishment dalam membentuk disiplin pada anak usia 5-6 tahun pada masa BDR di TK Putra 1 Mataram. Teknik pengumpulan data menggunakan observasi, wawancaa, dan dokumentasi. Adapun yang menjadi sumber data primer adalah Kepala Sekolah TK Putra 1 Mataram dan guru-guru. Sedangkan. sumber data sekundernya yaitu perwakilan orang tua, dokumen, arsip, dan data lainnya. Untuk uji keabsahan data menggunakan triangulasi data. Hasil dari penelitian ini adalah reward dan punishment berdampak positif dalam membentuk disiplin pada anak ketika anak diberikan reward anak menjadi senang dan berusaha menunjukkan sikap positif dan disiplin dan ketika anak diberikan punishment ketika melakukan pelanggaran anak merasa jera dan mau memperbaiki kesalahannya. Adapun bentuk reward dan punishment yang diberikan yaitu kalimat pujian, penghargaan, hadiah, motivasi, sedangkan punishment berupa peringatan dan teguran.
Use of frozen-thawed sperm for ICSI improves fertility outcome in men with azoospermia
Authors: YURCİ Arzu , DOKUZEYLÜL GÜNGÖR Nur 
Published: May 2021

Özet
Amaç: Azospermi tanısı ile mTESE uygulanan hastalarda IVF/ICSI sonuçlarının taze veya dondurulmuş-çözülmüş testis spermi ile karşılaştırılması.
Gereç ve yöntem: Bu retrospektif kohort çalışması, Memorial ve BAU Tüp Bebek Merkezlerine 2017-2020 yılları arasında azospermi tanısıyla başvuran ve taze veya dondurulmuş testis spermi kullanılarak cerrahi sperm ekstraksiyonu ve ICSI uygulanan 260 infertil erkek üzerinde gerçekleştirildi. Hastalar belirtildiği gibi iki eşit gruba ayrıldı. Grup 1 (n = 130), ICSI ve ardından taze testis spermi kullanılarak embriyo transferi yapılan hastalardan oluşuyordu. Grup 2 (n = 130); donmuş çözdürülmüş testis spermi kullanılarak ICSI uygulanan hastalardan oluşuyordu. Çalışmamızın temel amacı dondurulmuş veya taze testis spermi kullanılarak ICSI/ET uygulanan her iki gruptaki hastaları klinik gebelik ve canlı doğum oranları açısından karşılaştırmaktır. Ek olarak, her iki grup hem demografik hem de diğer üreme parametreleri açısından karşılaştırıldı.
Bulgular: Taze sperm grubundaki hastaların total oosit, M II oosit ve 2 PN embriyo sayıları, dondurulmuş sperm grubuna göre anlamlı olarak yüksek bulundu (p
Comparison of bypass versus primary angioplasty for lower extremity chronic limb-threatening peripheral arterial diseases
Authors: ULUKAN Mustafa Özer , KARAKAYA Atalay , UĞURLUCAN Murat , ERKANLI Korhan 
Published: May 2021

Aim: Peripheral arterial Diseases (PAD) is seen frequently with increasing age, and have a prevalence of about 20% over 70 years of age. We aimed the results of two different treatment approaches as open surgical procedures and radiological interventions.
Methods: We reviewed the data of PAD from the online data system of the hospital. The patients treated by endovascular femoropopliteal revascularization versus open surgical femoropopliteal graft bypass between January 2016 and December 2019 were enrolled in to study. Eighty limbs of 67 patients with the symptomatic severe occlusive disease and results were evaluated in the aspect of reducing ischemia and prevention of amputation in this retrospective study.
Results: 67 patients were divided into two groups. Group 1(n=29) was the interventional PTA/S group, group 2 (n=38) was the open surgical bypass group. 8 of the patients in Group 2 and 5 of patients in Group 1 had bilateral lesions. Patients were at a mean age of 63.44±8.98 years. The mean time of hospitalization time was significantly longer following a first-time bypass (10 vs. 8 days). The success of results was ending of claudication and ischemia and prevention of amputation of an extremity. In these aspects, there was no difference between procedure types.
Conclusion: In the aspect of the length of hospital stay and infection, interventional procedures seem more benefit however in long-term evaluation, freedom from reintervention or redo bypass was significantly higher in the bypass group (92% vs 79 % p
A vasúthálózatok értékelése a hadszíntéri logisztikai felderítés végrehajtásakor
Authors: Szajkó Gyula , Lévai Zsolt 
Published: May 2021

A cikk azokat a lehetséges feladatokat vizsgálja, amelyek fontosak lehetnek a hadszíntéri logisztikai felderítéshez kapcsolódóan, a vasúti infrastruktúra-elemek és gördülő állomány értékelésekor. Az erők hadszíntérre történő átcsoportosításakor több szállítási módszert (légi, vízi, vasúti, közúti szállítást) is alkalmazhatnak a logisztikai támogatást tervező, szervező személyek attól függően, hogy a kijelölt kötelékeknek hol, mikor és milyen jellegű műveletben kell részt venniük. A vasúthálózatok ( (infrastruktúrák) felderítéséből, értékeléséből származó információk (az út és úthálózatok mellett) kiemelt szerepet tölthetnek be az erők szárazföldi mobilitási képességének fenntartásakor, amikor nagy létszámú személyi állományt és haditechnikai eszközt szükséges mozgatni. A cikkben a szerzők bemutatnak egy szemrevételezésiszempont-listát, amely a logisztikai felderítés végrehajtásához és az erők vasúton történő szállításának megtervezéséhez nyújt segítséget.
A járványos megbetegedések elleni harc Magyarországon a Nagy Háború időszakában, 1914-1918
Authors: Molnár Zoltán 
Published: May 2021

Az I. világháború borzalmai egyre súlyosabb formában érintették a hátország lakosságát. A mérhetetlenül nagy lelki megterhelésnek és az élet minden területén jelentkező hiánynak köszönhetően, a társadalom egésze fogékonyabbá vált a betegségekre. A háború során fokozatosan elterjedő éhezés, fázás, valamint a nincstelenség következtében fellépő járványok sorra szedték áldozataikat. Ezek közül a leginkább pusztítóak voltak a kolera, a hastífusz, a tuberkulózis, a vérhas, a himlő, a különböző nemi betegségek, illetve a háború végén nagy pusztítást végző spanyolnátha. A tanulmányban megvizsgálom mindezen betegségek kialakulásának legfőbb okait és a megfékezésükre tett intézkedések hatásait.
The Impact of the University in Increasing the Book Reading on Students: Case Study Soran University
Authors: İşleyen Şakir , Amir Khaleel Hassoo  
Published: May 2021

Reading is perusing through texts to understand concepts. In the event that you battle to centre, reading can improve your attention span. Books with better structures encourage us to think in sequence the more we read, the more our brains are able to link cause and effect. The main aim of this study is to investigate the effective factors that the role of the university in reading books. The sample of the study includes all the students at Soran University. The focused on populace size for the investigation is 400 understudies who chose haphazardly. The acquired information were broke down with the SPSS program by using methods containing descriptive statistics, Chi-square test. The results indicated some factors such as good communication between reading a book and students, offering university and professional development courses with a variety of skills for students, The research includes “Individual Reasons”, “age group”, “Perusing material during recreation time”, “Department”, play a significant role in reading book students in the university.
Enhanced Susceptibility to Breast Cancer in Korean Women With Elevated Serum Gamma-Glutamyltransferase Levels: A Nationwide Population-Based Cohort Study
Authors: Seol Aeran , Wang Wenyu , Kim Se Ik , Han Youngjin , Park In Sil , Yoo Juhwan , Jo HyunA , Han Kyung-Do , Song Yong Sang 
Published: May 2021

BackgroundThe incidence of breast cancer has been gradually increasing in Korea. Recently, the elevated level of serum gamma-glutamyltransferase (GGT) has emerged to be associated with the development and progression of some malignancies. This study aimed to determine the effect of serum GGT levels on the risk of developing breast cancer in Korean women.MethodsWe used National Health Insurance Service Health Checkup data to examine the association between serum GGT levels and breast cancer development in Korean women. Women aged 40 years or older who participated in the Korean National Health Screening Examination between January 2009 and December 2009 and who did not develop any cancer within 1-year post examination were included in this analysis (n = 3,109,506). Cox proportional hazard regression analysis was conducted to calculate hazard ratios (HRs) with 95% confidence intervals (CIs).ResultsOverall, an elevated serum GGT level was associated with the increased risk of developing breast cancer; compared to the Q1 group, the Q4 group showed a significantly increased breast cancer risk (HR: 1.120,95% CI: 1.08–1.162). Such a relationship was stronger in post-menopausal women than pre-menopausal women (HR: 1.173, 95% CI: 1.107–1.243; HR: 1.070, 95% CI:1.019–1.124). Women with a high GGT level (Q4) were also at an increased risk of developing carcinoma in situ (CIS) (HR: 1.114, 95% CI: 1.04–1.192). In post-menopausal women, the Q4 group also exhibited higher CIS risk (HR: 1.266, 95% CI: 1.132–1.416). However, no significant difference in the risk of developing CIS was observed between the Q1 and Q4 groups in pre-menopausal women. Further analysis revealed that obese, post-menopausal women with a high GGT level (Q4) were associated with an increased risk of developing breast cancer (HR: 1.214, 95% CI: 1.125–1.31) and CIS (HR: 1.348, 95% CI: 1.159–1.569).ConclusionsOur study results demonstrate that increased serum GGT level is a risk factor for developing breast cancer. The post-menopausal women group with obesity and elevated serum GGT level showed the highest incidence of breast cancer. Thus, serum GGT concentration could be a novel and potential risk factor for breast cancer. Further validation in different ethnic groups would be warranted.