bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optical Properties of C-rich (12C, SiC and FeC) Dust Layered Structure of Massive Stars*
Authors: Wu Rui-Qing , Long Meng-Qiu , Zhang Xiao-Jiao , Wang Yun-Peng , Yao Meng-Li , Li Ming-Ming , Zhu Chun-Hua , Lü Guo-Liang , Wang Zhao-Jun , Zhang Ju-Jia , Wang Zhao , Chen Wu-Jin 
Published: December 2021

Abstract
The composition and structure of interstellar dust are important and complex for the study of the evolution of stars and the interstellar medium (ISM). However, there is a lack of corresponding experimental data and model theories. By theoretical calculations based on ab-initio method, we have predicted and geometry optimized the structures of Carbon-rich (C-rich) dusts, carbon (12C), iron carbide (FeC), silicon carbide (SiC), even silicon (28Si), iron (56Fe), and investigated the optical absorption coefficients and emission coefficients of these materials in 0D (zero-dimensional), 1D, and 2D nanostructures. Comparing the nebular spectra of the supernovae (SN) with the coefficient of dust, we find that the optical absorption coefficient of the 2D 12C, 28Si, 56Fe, SiC and FeC structure corresponds to the absorption peak displayed in the infrared band (5–8) μm of the spectrum at 7554 days after the SN1987A explosion. It also corresponds to the spectrum of 535 days after the explosion of SN2018bsz, when the wavelength was in the range of (0.2–0.8) and (3–10) μm. Nevertheless, 2D SiC and FeC correspond to the spectrum of 844 days after the explosion of SN2010jl, when the wavelength is within (0.08–10) μm. Therefore, FeC and SiC may be the second type of dust in SN1987A corresponding to infrared band (5–8) μm of dust and may be in the ejecta of SN2010jl and SN2018bsz. The nano-scale C-rich dust size is ∼0.1 nm in SN2018bsz, which is 3 orders of magnitude lower than the value of 0.1 μm. In addition, due to the ionization reaction in the supernova remnant (SNR), we also calculated the Infrared Radiation (IR) spectrum of dust cations. We find that the cation of the 2D layered (SiC)2+ has a higher IR spectrum than those of the cation (SiC)1+ and neutral (SiC)0+.
tACS facilitates flickering driving by boosting steady-state visual evoked potentials
Authors: Liu Bingchuan , Yan Xinyi , Chen Xiaogang , Wang Yijun , Gao Xiaorong 
Published: December 2021

Abstract

Objective. There has become of increasing interest in transcranial alternating current stimulation (tACS) since its inception nearly a decade ago. tACS in modulating brain state is an active area of research and has been demonstrated effective in various neuropsychological and clinical domains. In the visual domain, much effort has been dedicated to brain rhythms and rhythmic stimulation, i.e. tACS. However, less is known about the interplay between the rhythmic stimulation and visual stimulation. Approach. Here, we used steady-state visual evoked potential (SSVEP), induced by flickering driving as a widely used technique for frequency-tagging, to investigate the aftereffect of tACS in healthy human subjects. Seven blocks of 64-channel electroencephalogram were recorded before and after the administration of 20min 10Hz tACS, while subjects performed several blocks of SSVEP tasks. We characterized the physiological properties of tACS aftereffect by comparing and validating the temporal, spatial, spatiotemporal and signal-to-noise ratio (SNR) patterns between and within blocks in real tACS and sham tACS. Main results. Our result revealed that tACS boosted the 10Hz SSVEP significantly. Besides, the aftereffect on SSVEP was mitigated with time and lasted up to 5 min. Significance. Our results demonstrate the feasibility of facilitating the flickering driving by external rhythmic stimulation and open a new possibility to alter the brain state in a direction by noninvasive transcranial brain stimulation.
Engineering sensitivity and spectral range of photodetection in van der Waals materials and hybrids
Authors: Sett Shaili , Parappurath Aparna , Gill Navkiranjot Kaur , Chauhan Neha , Ghosh Arindam 
Published: December 2021

Abstract
Exploration of van der Waals heterostructures in the field of optoelectronics has produced photodetectors with very high bandwidth as well as ultra-high sensitivity. Appropriate engineering of these heterostructures allows us to exploit multiple light-to-electricity conversion mechanisms, ranging from photovoltaic, photoconductive to photogating processes. These mechanisms manifest in different sensitivity and speed of photoresponse. In addition, integrating graphene-based hybrid structures with photonic platforms provides a high gain-bandwidth product, with bandwidths ≫1 GHz. In this review, we discuss the progression in the field of photodetection in 2D hybrids. We emphasize the physical mechanisms at play in diverse architectures and discuss the origin of enhanced photoresponse in hybrids. Recent developments in 2D photodetectors based on room temperature detection, photon-counting ability, integration with Si and other pressing issues, that need to be addressed for these materials to be integrated with industrial standards have been discussed.
JEBIN: analyzing gene co-expressions across multiple datasets by joint network embedding
Authors: Wu Guiying , Li Xiangyu , Guo Wenbo , Wei Zheng , Hu Tao , Shan Yiran , Gu Jin 
Published: December 2021

AbstractThe inference of gene co-expression associations is one of the fundamental tasks for large-scale transcriptomic data analysis. Due to the high dimensionality and high noises in transcriptomic data, it is difficult to infer stable gene co-expression associations from single dataset. Meta-analysis of multisource data can effectively tackle this problem. We proposed Joint Embedding of multiple BIpartite Networks (JEBIN) to learn the low-dimensional consensus representation for genes by integrating multiple expression datasets. JEBIN infers gene co-expression associations in a nonlinear and global similarity manner and can integrate datasets with different distributions in linear time complexity with the gene and total sample size. The effectiveness and scalability of JEBIN were verified by simulation experiments, and its superiority over the commonly used integration methods was proved by three indexes on real biological datasets. Then, JEBIN was applied to study the gene co-expression patterns of hepatocellular carcinoma (HCC) based on multiple expression datasets of HCC and adjacent normal tissues, and further on latest HCC single-cell RNA-seq data. Results show that gene co-expressions are highly different between bulk and single-cell datasets. Finally, many differentially co-expressed ligand–receptor pairs were discovered by comparing HCC with adjacent normal data, providing candidate HCC targets for abnormal cell–cell communications.
TransportTools: a library for high-throughput analyses of internal voids in biomolecules and ligand transport through them
Authors: Brezovsky Jan , Thirunavukarasu Aravind Selvaram , Surpeta Bartlomiej , Sequeiros-Borja Carlos Eduardo , Mandal Nishita , Sarkar Dheeraj Kumar , Dongmo Foumthuim Cedrix J , Agrawal Nikhil 
Published: December 2021

Abstract

Summary
Information regarding pathways through voids in biomolecules and their roles in ligand transport is critical to our understanding of the function of many biomolecules. Recently, the advent of high-throughput molecular dynamics simulations has enabled the study of these pathways, and of rare transport events. However, the scale and intricacy of the data produced requires dedicated tools in order to conduct analyses efficiently and without excessive demand on users. To fill this gap, we developed the TransportTools, which allows the investigation of pathways and their utilization across large, simulated datasets. TransportTools also facilitates the development of custom-made analyses.

Availability and implementation
TransportTools is implemented in Python3 and distributed as pip and conda packages. The source code is available at https://github.com/labbit-eu/transport_tools. Data are available in a repository and can be accessed via a link: https://doi.org/10.5281/zenodo.5642954.

Supplementary information
Supplementary data are available at Bioinformatics online.
The effects of vitrification on oocyte quality
Authors: Chang Ching-Chien , Shapiro Daniel B , Nagy Zsolt Peter 
Published: December 2021

Abstract
Vitrification, is an ultra-rapid, manual cooling process that produces glass-like (ice crystal-free) solidification. Water is prevented from forming intercellular and intracellular ice crystals during cooling as a result of oocyte dehydration and the use of highly concentrated cryoprotectant. Though oocytes can be cryopreserved without ice crystal formation through vitrification, it is still not clear whether the process of vitrification causes any negative impact (temperature change/chilling effect, osmotic stress, cryoprotectant toxicity, and/or phase transitions) on oocyte quality, which translates to diminished embryo developmental potential or subsequent clinical outcomes. In this review, we attempt to assess the technique’s potential effects and the consequence of these effects on outcomes.
Tourists’ Digital Footprint: Prediction Method of Tourism Consumption Decision Preference
Authors: Sun Qiong , Huang Xiankai , Liu Zheng 
Published: December 2021

AbstractDigital footprints converge into a complex individual and group behavior picture, which truly reflects the user’s choice preference and deep-seated behavior law. However, its application in tourism needs to be further explored. Based on the core characteristics of consumption footprint, this paper applies it to tourism field to analyze tourists’ consumption behavior based on the theory of digital footprint and consumer behavior. This study aims at mining text data, analyzing its characteristics, creating a digital footprint integrated learning model and developing the mining and analysis technology of tourism digital footprints. This method can improve the accuracy of consumer decision-making tendency prediction, and the prediction results can be used to formulate targeted consumption strategies, so as to effectively stimulate consumption vitality and improve consumer satisfaction.
Hypoplastic coronary artery disease and hypertension in a child: a case report
Authors: Doi Yuji , Waki Kenji , Ogino Kayo , Hayashi Tomohiro 
Published: December 2021

Abstract

Background
Hypoplastic coronary artery disease (HCAD) is an extremely rare disease associated with a risk of sudden cardiac death. It is rarely recognized in a live paediatric patient.

Case summary
We report a case of HCAD in a patient who first presented with vomiting and poor feeding, suggestive of acute heart failure due to cardiomyopathy or acute myocarditis in infancy. Hypertension and signs of ischaemia became evident on electrocardiography and scintigraphy after his cardiac function fully recovered, and he was diagnosed with HCAD by angiography performed at the age of 8 years. He has remained under close observation with anti-hypertensives, aspirin, and exercise restriction.

Discussion
Although HCAD is a rare disease, it may not only cause ischaemia but may also result in heart failure and sudden cardiac death. It should be considered in any paediatric patient with heart failure. Mid-term follow-up visits might be necessary to detect signs of ischaemia in paediatric patients presenting with features of heart failure.
An autopsy case of pulmonary arterial hypertension in an elderly patient with multimorbidity: a case report
Authors: Yokose Masashi , Tomoe Takashi , Yamaguchi Takehiko , Yasu Takanori 
Published: December 2021

Abstract

Background
There is an increasing number of elderly patients with pulmonary arterial hypertension (PAH), and their characteristics differ from those of young or middle-aged patients with this condition.

Case summary
A 73-year-old woman with a history of myocardial infarction and cardiovascular risk factors was admitted to the hospital with 2-week exertional dyspnoea. Her initial diagnosis was heart failure with preserved ejection fraction, but the symptoms persisted despite receiving treatment with diuretics. Additional tests showed a significant decrease in diffusing capacity of carbon monoxide and findings suggestive of severe pulmonary hypertension (PH). Contrast-enhanced computed tomography of the chest, and pulmonary angiography, showed no narrowing or obstruction of the pulmonary arteries. Right heart catheterization revealed haemodynamic data implying pre-capillary PH. Her condition gradually deteriorated to World Health Organization functional class IV, and sequential combination therapy with tadalafil, macitentan, and selexipag was initiated with a PAH diagnosis; however, she died 1 month later. Pathological findings in autopsy were consistent with PAH, and some parts of the lungs revealed the presence of obstructive and interstitial lung disease.

Discussion
The majority of elderly patients with PAH might have multimorbidity. However, there is no specific treatment strategy. It is associated with diagnostic delay and worse prognosis; therefore, early suspicion and comprehensive tests, including right heart catheterization, are essential for better management.
Multi-organ assessment in mainly non-hospitalized individuals after SARS-CoV-2 infection: The Hamburg City Health Study COVID programme
Authors: Petersen Elina Larissa , Goßling Alina , Adam Gerhard , Aepfelbacher Martin , Behrendt Christian-Alexander , Cavus Ersin , Cheng Bastian , Fischer Nicole , Gallinat Jürgen , Kühn Simone , Gerloff Christian , Koch-Gromus Uwe , Härter Martin , Hanning Uta , Huber Tobias B. , Kluge Stefan , Knobloch Johannes K. , Kuta Piotr , Schmidt-Lauber Christian , Lütgehetmann Marc , Magnussen Christina , Mayer Carola , Muellerleile Kai , Münch Julia , Nägele Felix Leonard , Petersen Marvin , Renné Thomas , Riedl Katharina Alina , Rimmele David Leander , Schäfer Ines , Schulz Holger , Tahir Enver , Waschki Benjamin , Wenzel Jan-Per , Zeller Tanja , Ziegler Andreas , Thomalla Götz , Twerenbold Raphael , Blankenberg Stefan 
Published: December 2021

Abstract

Aims
Long-term sequelae may occur after SARS-CoV-2 infection. We comprehensively assessed organ-specific functions in individuals after mild to moderate SARS-CoV-2 infection compared with controls from the general population.

Methods and results
Four hundred and forty-three mainly non-hospitalized individuals were examined in median 9.6 months after the first positive SARS-CoV-2 test and matched for age, sex, and education with 1328 controls from a population-based German cohort. We assessed pulmonary, cardiac, vascular, renal, and neurological status, as well as patient-related outcomes. Bodyplethysmography documented mildly lower total lung volume (regression coefficient −3.24, adjusted P = 0.014) and higher specific airway resistance (regression coefficient 8.11, adjusted P = 0.001) after SARS-CoV-2 infection. Cardiac assessment revealed slightly lower measures of left (regression coefficient for left ventricular ejection fraction on transthoracic echocardiography −0.93, adjusted P = 0.015) and right ventricular function and higher concentrations of cardiac biomarkers (factor 1.14 for high-sensitivity troponin, 1.41 for N-terminal pro-B-type natriuretic peptide, adjusted P ≤ 0.01) in post-SARS-CoV-2 patients compared with matched controls, but no significant differences in cardiac magnetic resonance imaging findings. Sonographically non-compressible femoral veins, suggesting deep vein thrombosis, were substantially more frequent after SARS-CoV-2 infection (odds ratio 2.68, adjusted P &lt; 0.001). Glomerular filtration rate (regression coefficient −2.35, adjusted P = 0.019) was lower in post-SARS-CoV-2 cases. Relative brain volume, prevalence of cerebral microbleeds, and infarct residuals were similar, while the mean cortical thickness was higher in post-SARS-CoV-2 cases. Cognitive function was not impaired. Similarly, patient-related outcomes did not differ.

Conclusion
Subjects who apparently recovered from mild to moderate SARS-CoV-2 infection show signs of subclinical multi-organ affection related to pulmonary, cardiac, thrombotic, and renal function without signs of structural brain damage, neurocognitive, or quality-of-life impairment. Respective screening may guide further patient management.
Primary COVID-19 vaccine cycle and booster doses efficacy: analysis of Italian nationwide vaccination campaign
Authors: Mattiuzzi Camilla , Lippi Giuseppe 
Published: December 2021

Abstract
We provide here an updated analysis of primary COVID-19 vaccination and vaccine booster doses efficacy, emerging from the ongoing Italian nationwide COVID-19 vaccination campaign. Primary COVID-19 vaccination efficacy was 76–92% within 6 months, decreasing to 34–80% after 6 months. Administration of vaccine booster doses decreased SARS-CoV-2 infections by 65%, COVID-19-related hospitalizations and deaths by 69% and 97% compared with vaccine efficacy after 6 months, but also decreased SARS-CoV-2 infections by 39% compared with vaccine efficacy within 6 months. These results suggest that COVID-19 vaccine booster doses are important for restoring vaccine efficacy and further limiting virus circulation.
Clinimetric Evaluation of the Experienced Communication in Dementia Questionnaire
Authors: Olthof-Nefkens Maria W L J , Derksen Els W C , Lambregts Britt , de Swart Bert J M , Nijhuis-van der Sanden Maria W G , Kalf Johanna G 
Published: December 2021

Abstract

Background and Objectives
Tools to measure self-perceived communication between persons with early-stage dementia and their caregivers are lacking. Therefore, we developed a questionnaire for Experienced Communication in Dementia (ECD) with a patient version (ECD-P) and a caregiver version (ECD-C), which contains items on (a) caregiver competence, (b) social communication, (c) communication difficulties, and (d) experienced emotions. This article describes the feasibility and clinimetric evaluation of this instrument.

Research Design and Methods
A prospective observational cohort study was conducted with 57 dyads (community-dwelling person with dementia and primary caregiver). ECD-P, ECD-C, and measures on quality of life, caregiver burden, cognitive functioning, physical functioning, and functional independence were administered. After 2 weeks, the dyads filled out the ECD again. Feasibility (completion time and missing values per item), internal consistency (Cronbach’s α), test–retest reliability (intraclass correlation coefficients [ICCs]), and construct validity (hypotheses testing with Spearman’s r) were evaluated.

Results
Mean completion time was 10 min per questionnaire. ICCs for test–retest reliability ranged from 0.67 to 0.78, except for ECD-P2 (ICC = 0.31). Internal consistency ranged from α = 0.75 to 0.82 for ECD-P1 and all parts of ECD-C, except for ECD-P2 (α = 0.66). Correlation coefficients for convergent validity ranged from r = 0.31 to 0.69 and correlation coefficients for divergent validity were r &lt; 0.20 and statistically insignificant.

Discussion and Implications
Pending future research, the ECD, except part ECD-P2, seems to be a promising tool to measure experienced communication between persons with early-stage dementia and their caregivers.
FHIRedApp: a LEAP in health information technology for promoting patient access to their medical information
Authors: Khurshid Anjum , Oliveira Eliel , Nordquist Eric , Lakshminarayanan Vidya , Abrol Vishal 
Published: December 2021

Abstract

Objective
Our aim is to develop a patient engagement technology that makes it easy for patients to access their own medical information and share it with others.

Materials and Methods
This paper describes our design through an adapted Community Engagement Studio methodology to identify the needs and preferences of a diverse group of Latinx, African–American, and Asian–American individuals in the community. We use Human-Centered Design to interpret these needs and preferences to build a digital app platform, using national data standards, clinical data aggregators, and privacy-preserving solutions while maintaining the security and confidentiality of patients.

Results
We designed and developed FHIRedApp, an app platform, that allows patients to access their data and to share that access as HL7® FHIR® application programming interfaces with third-party app developers. We accomplished 2 major tasks: first, to demonstrate the use of interoperability and authentication standards, such as HL7® FHIR and OAuth2, to help develop patient engagement technologies, and second, to co-develop and co-design FHIRedApp with active involvement of African–American, Latinx, and Asian–American community members. Usability results show high satisfaction rates for FHIRedApp.

Conclusion
The development of FHIRedApp demonstrates how technology innovations using national interoperability standards can be informed through a methodology of community engagement and human-centered design that involves local racial and ethnic groups.
International COVID-19 mortality forecast visualization: covidcompare.io
Authors: Akre Samir , Liu Patrick Y , Friedman Joseph R , Bui Alex A T 
Published: December 2021

Abstract
COVID-19 mortality forecasting models provide critical information about the trajectory of the pandemic, which is used by policymakers and public health officials to guide decision-making. However, thousands of published COVID-19 mortality forecasts now exist, many with their own unique methods, assumptions, format, and visualization. As a result, it is difficult to compare models and understand under which circumstances a model performs best. Here, we describe the construction and usability of covidcompare.io, a web tool built to compare numerous forecasts and offer insight into how each has performed over the course of the pandemic. From its launch in December 2020 to June 2021, we have seen 4600 unique visitors from 85 countries. A study conducted with public health professionals showed high usability overall as formally assessed using a Post-Study System Usability Questionnaire. We find that covidcompare.io is an impactful tool for the comparison of international COVID-19 mortality forecasting models.