bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spotted hyena optimizer algorithm for capacitor allocation in radial distribution system with distributed generation and microgrid operation considering different load types
Authors: Naderipour Amirreza , Abdul-Malek Zulkurnain , Hajivand Mohammad , Seifabad Zahra Mirzaei , Farsi Mohammad Ali , Nowdeh Saber Arabi , Davoudkhani Iraj Faraji 
Published: February 2021

AbstractIn this paper, the optimal allocation of constant and switchable capacitors is presented simultaneously in two operation modes, grid-connected and islanded, for a microgrid. Different load levels are considered by employing non-dispatchable distributed generations. The objective function includes minimising the energy losses cost, the cost of peak power losses, and the cost of the capacitor. The optimization problem is solved using the spotted hyena optimizer (SHO) algorithm to determine the optimal size and location of capacitors, considering different loading levels and the two operation modes. In this study, a three-level load and various types of loads, including constant power, constant current, and constant impedance are considered. The proposed method is implemented on a 24-bus radial distribution network. To evaluate the performance of the SHO, the results are compared with GWO and the genetic algorithm (GA). The simulation results demonstrate the superior performance of the SHO in reducing the cost of losses and improving the voltage profile during injection and non-injection of reactive power by distributed generations in two operation modes. The total cost and net saving values for DGs only with the capability of active power injection is achieved 105,780 $ and 100,560.54 $, respectively and for DGs with the capability of active and reactive power injection is obtained 89,568 $ and 76,850.46 $, respectively using the SHO. The proposed method has achieved more annual net savings due to the lower cost of losses than other optimization methods.
An open source machine learning framework for efficient and transparent systematic reviews
Authors: van de Schoot Rens , de Bruin Jonathan , Schram Raoul , Zahedi Parisa , de Boer Jan , Weijdema Felix , Kramer Bianca , Huijts Martijn , Hoogerwerf Maarten , Ferdinands Gerbrich , Harkema Albert , Willemsen Joukje , Ma Yongchao , Fang Qixiang , Hindriks Sybren , Tummers Lars , Oberski Daniel L. 
Published: February 2021

AbstractTo help researchers conduct a systematic review or meta-analysis as efficiently and transparently as possible, we designed a tool to accelerate the step of screening titles and abstracts. For many tasks—including but not limited to systematic reviews and meta-analyses—the scientific literature needs to be checked systematically. Scholars and practitioners currently screen thousands of studies by hand to determine which studies to include in their review or meta-analysis. This is error prone and inefficient because of extremely imbalanced data: only a fraction of the screened studies is relevant. The future of systematic reviewing will be an interaction with machine learning algorithms to deal with the enormous increase of available text. We therefore developed an open source machine learning-aided pipeline applying active learning: ASReview. We demonstrate by means of simulation studies that active learning can yield far more efficient reviewing than manual reviewing while providing high quality. Furthermore, we describe the options of the free and open source research software and present the results from user experience tests. We invite the community to contribute to open source projects such as our own that provide measurable and reproducible improvements over current practice.
Hören Sie mal!
Authors: Sommer Armanso 
Published: February 2021

ZusammenfassungSchluss mit verwirrenden Nachrichten oder irreführender Werbung zwischen unpassender Musik und viel zu schneller Moderation für Senioren. Der Verein „Wir sind Altenpflege e. V.“ gestaltet Musik für ältere Menschen.
Outcome of Major Hemorrhage at a Major Cardiothoracic Center in Patients with Activated Major Hemorrhage Protocol versus Nonactivated Protocol
Authors: Chang Kathryn W. , Owen Steve , Gaspar Michaela , Laffan Mike , Arachchillage Deepa R. J. 
Published: February 2021

AbstractThis study aimed to determine the impact of major hemorrhage (MH) protocol (MHP) activation on blood administration and patient outcome at a UK major cardiothoracic center. MH was defined in patients (> 16 years) as those who received > 5 units of red blood cells (RBCs) in < 4 hours, or > 10 units in 24 hours. Data were collected retrospectively from patient electronic records and hospital transfusion databases recording issue of blood products from January 2016 to December 2018. Of 134 patients with MH, 24 had activated MHP and 110 did not have activated MHP. Groups were similar for age, sex, baseline hemoglobin, platelet count, coagulation screen, and renal function with no difference in the baseline clinical characteristics. The total number of red cell units (median and [IQR]) transfused was no different in the patients with activated (7.5 [5–11.75]) versus nonactivated (9 [6–12]) MHP (p = 0.35). Patients in the nonactivated MHP group received significantly higher number of platelet units (median: 3 vs. 2, p = 0.014), plasma (median: 4.5 vs. 1.5, p = 0.0007), and cryoprecipitate (median: 2 vs. 1, p = 0.008). However, activation of MHP was associated with higher mortality at 24 hours compared with patients with nonactivation of MHP (33.3 vs. 10.9%, p = 0.005) and 30 days (58.3 vs. 30.9%, p = 0.01). The total RBC and platelet (but not fresh frozen plasma [FFP]) units received were higher in deceased patients than in survivors. Increased mortality was associated with a higher RBC:FFP ratio. Only 26% of patients received tranexamic acid and these patients had higher mortality at 30 days but not at 24 hours. Deceased patients at 30 days had higher levels of fibrinogen than those who survived (median: 2.4 vs. 1.8, p = 0.01). Patients with activated MHP had significantly higher mortality at both 24 hours and 30 days despite lack of difference in the baseline characteristics of the patients with activated MHP versus nonactivated MHP groups. The increased mortality associated with a higher RBC:FFP ratio suggests dilutional coagulopathy may contribute to mortality, but higher fibrinogen at baseline was not protective.
Composite pressure cell for pulsed magnets
Authors: Sun Dan , Naud Martin F. , Nguyen Doan N. , Betts Jonathan B. , Singleton John , Balakirev Fedor F. 
Published: February 2021

Extreme pressures and high magnetic fields can affect materials in profound and fascinating ways. However, large pressures and fields are often mutually incompatible; the rapidly changing fields provided by pulsed magnets induce eddy currents in the metallic components used in conventional pressure cells, causing serious heating, forces, and vibration. Here, we report a diamond-anvil-cell made mainly out of insulating composites that minimizes inductive heating while retaining sufficient strength to apply pressures of up to 8 GPa. Any residual metallic component is made of low-conductivity metals and patterned to reduce eddy currents. The simple design enables rapid sample or pressure changes, desired by pulsed-magnetic-field-facility users. The pressure cell has been used in pulsed magnetic fields of up to 65 T with no noticeable heating at cryogenic temperatures. Several measurement techniques are possible inside the cell at temperatures as low as 500 mK.
A simple Field Programmable Gate Array (FPGA) based high precision low-jitter delay generator
Authors: Chen Zeyang , Wang Xiaohan , Zhou Ziwen , Moro Ramiro , Ma Lei 
Published: February 2021

Pulse delay generators are ubiquitous in laboratories to coordinate and control the timing between different devices in applications that include lasers, mass spectrometers, and other scientific instruments. The most important required characteristics are precision, to control time exactly, and low-jitter, to minimize uncertainty in experiments. Here, we introduce a new design of a high precision and low-jitter digital delay generator based on a Field Programmable Gate Array (FPGA). The final delay is composed of steps of 4.2 ns (coarse delay) with fine steps of 16 ps (fine delay). The coarse delay is generated by a 240 MHz pulse sequence from the FPGA with a 50 MHz clock. An embedded time-to-digital conversion unit is used to measure the interval between the external trigger and the clock signal, which, together with an integrated delay generator, is used to realize the fine delay. Jitter compensation is achieved through a measurement-and-feedback module. A computer interface is designed to control the system through a Nios II processor. Measurements confirm a time resolution of 16 ± 2 ps with jitter below 450 ± 20 ps (at 24 °C) with a maximum delay of 1 s. The whole system is simple in structure and low in cost.
Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10
Authors: Muñoz Melba , Hegazy Ahmed N. , Brunner Tobias M. , Holecska Vivien , Marek Roman M. , Fröhlich Anja , Löhning Max 
Published: February 2021

SignificanceStrategies to suppress memory T cell responses are needed. Th2-polarized cells lacking the transcription factor T-bet strongly suppress not only naive but also memory T cell responses via IL-10 and protect mice against the development of virus-induced type 1 diabetes. We shed light on a population of immune cells with substantial immunomodulatory capacity.
Conjugative plasmids interact with insertion sequences to shape the horizontal transfer of antimicrobial resistance genes
Authors: Che You , Yang Yu , Xu Xiaoqing , Břinda Karel , Polz Martin F. , Hanage William P. , Zhang Tong 
Published: February 2021

Significance
There is great interest in understanding how antibiotic resistance is disseminated by MGEs (i.e., plasmids, insertion sequences, and integrons). We have systematically investigated their interactions in mediating the horizontal transfer of resistance by combining in silico genomic analysis of a large collection of complete bacterial plasmids (14,029) and genomes (12,059), and then confirmed the interactions we observe in nature using direct experimental approaches. We showed a whole picture of all the IS-associated transfer patterns of AMR genes across different genetic backgrounds and our results highlight the significant relationships between conjugative plasmids and ISs in shaping the dissemination of AMR genes.
High-resolution imaging reveals compartmentalization of mitochondrial protein synthesis in cultured human cells
Authors: Zorkau Matthew , Albus Christin A. , Berlinguer-Palmini Rolando , Chrzanowska-Lightowlers Zofia M. A. , Lightowlers Robert N. 
Published: February 2021

SignificanceIn mitochondria from various species, the OXPHOS complexes reside mainly in the invaginated cristae membranes, as opposed to the inner boundary membrane (IBM) that parallels the mitochondrial outer membrane. However, the IBM contains dynamic contact sites enriched for translocases that import proteins from the cytosol. As the majority of OXPHOS components are imported and need to be integrated in assembly with the mtDNA-encoded components, where does intramitochondrial translation occur? Here we report: 1) a method for visualizing protein synthesis in human mitochondria at super resolution; 2) that synthesis is enriched at cristae membranes, in preference to the IBM; and 3) that sites of translation are spatially separated from RNA granules where RNA processing, maturation, and mitoribosomal assembly occur.
Area-specific thalamocortical synchronization underlies the transition from motor planning to execution
Authors: Nashef Abdulraheem , Mitelman Rea , Harel Ran , Joshua Mati , Prut Yifat 
Published: February 2021

Significance
Thalamocortical interactions are a key component of normal brain functions both in sensory and motor areas. The fact that TC connectivity is excitatory has led to the suggestion that its main role is positively driving motor cortical activity. Here we show that the motor thalamus has contrasting, area-dependent interactions with cortical sites, such that it can either enhance or suppress motor cortical variability. The TC interactions with the primary motor vs. the premotor cortex put the motor thalamus in an ideal position to promote the transition from a motor plan to motor action and serve as an important driver of movement initiation.
The KRAS and other prenylated polybasic domain membrane anchors recognize phosphatidylserine acyl chain structure
Authors: Zhou Yong , Prakash Priyanka S. , Liang Hong , Gorfe Alemayehu A. , Hancock John F. 
Published: February 2021

Significance
Electrostatics have been thought to dominate interactions between a polybasic membrane anchoring motif and anionic lipids in the plasma membrane. Combining data from computational and imaging techniques, here we show that distinct conformational dynamics and interaction patterns of prenylated polybasic domains encode specificity for lipid acyl chain saturation. This previously unrecognized capacity to distinguish between acyl chain structures renders the anchor sensitive to the biophysical properties of the membrane, which are in turn determined by the acyl chain structure of the composite lipids. We propose that lipid acyl chain structure and dynamics participate in the regulation of the spatial distribution of prenylated polybasic membrane anchors found in many membrane-bound small GTPases, and possibly polybasic domains in other membrane associated proteins.
Consequences of aneuploidy in human fibroblasts with trisomy 21
Authors: Hwang Sunyoung , Cavaliere Paola , Li Rui , Zhu Lihua Julie , Dephoure Noah , Torres Eduardo M. 
Published: February 2021

Significance
An abnormal number of chromosomes or aneuploidy accounts for most spontaneous abortions, as missegregation of a single chromosome during development is often lethal. Only individuals with trisomy 21, which causes Down syndrome, can live to adulthood but show cognitive disabilities, increased risk for leukemias, autoimmune disorders, and clinical symptoms associated with premature aging. The mechanisms by which aneuploidy affects cellular function to cause Down syndrome are not understood. Our studies revealed that aneuploidy causes several defects in cells from individuals with Down syndrome. These include increased gene and protein expression, lower viability, and increased dependency on serine to proliferate. Our studies establish a critical role of aneuploidy, independent of triplicated gene identity, in driving cellular defects associated with trisomy 21.
Histone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout
Authors: Zhao Shuai , Chuh Kelly N. , Zhang Baichao , Dul Barbara E. , Thompson Robert E. , Farrelly Lorna A. , Liu Xiaohui , Xu Ning , Xue Yi , Roeder Robert G. , Maze Ian , Muir Tom W. , Li Haitao 
Published: February 2021

Significance
Histone H3Q5ser and H3K4me3 can coexist as a dual modification pattern to regulate active gene transcription. However, the molecular impact of H3Q5ser on H3K4me3 recognition and catalysis remains largely unexplored. Here, we profile the influence of H3Q5ser on H3K4 methylation readers, writers, and erasers. Interestingly, all tested H3K4me3 readers bind H3K4me3Q5ser. Furthermore, while the activity of the H3K4 methyltransferase, MLL1, is unaffected by H3Q5ser, corresponding H3K4 methylation erasers are profoundly inhibited by the presence of the mark. Collectively, this work suggests that H3Q5ser plays an augmenting role when coupled with the installation of H3K4 methylation so as to potentiate downstream outputs via chromatin readers and erasers. The present work exemplifies the importance of modification crosstalk in gene regulation.
Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice
Authors: Ding Lili , Zhang Eryun , Yang Qiaoling , Jin Lihua , Sousa Kyle M. , Dong Bingning , Wang Yangmeng , Tu Jui , Ma Xiaoxiao , Tian Jingyan , Zhang Hongli , Fang Zhipeng , Guan Ana , Zhang Yixin , Wang Zhengtao , Moore David D. , Yang Li , Huang Wendong 
Published: February 2021

SignificanceVertical sleeve gastrectomy (VSG) is a highly effective bariatric surgery that sustainably treats obesity and type 2 diabetes (T2D). However, the underlying mechanisms governing its metabolic benefits remain unclear. In this study, we have used four different genetically modified mouse lines to understand the link between bile acid circulation and metabolic effects of VSG. Instead of directly activating the nuclear bile acid receptor farnesoid X receptor (Fxr) in the liver or intestine, VSG reduces intestinal levels of bile acids, thereby decreasing fat absorption in the intestine. Given the rising popularity of bariatric surgeries to treat obesity and associated T2D, the results described herein provide mechanistic insights that may lead to safer noninvasive approaches to mimic the metabolic effects of bariatric surgery.
Nonsurgical treatment of skin cancer with local delivery of bioadhesive nanoparticles
Authors: Hu Jamie K. , Suh Hee-Won , Qureshi Munibah , Lewis Julia M. , Yaqoob Sharon , Moscato Zoe M. , Griff Sofia , Lee Alison K. , Yin Emily S. , Saltzman W. Mark , Girardi Michael 
Published: February 2021

Significance
One in five individuals in the United States will develop skin cancer over the course of a lifetime, and nonsurgical options are limited. To address this, we developed a bioadhesive nanoparticle (BNP) treatment for long-lasting local drug delivery. Incorporation of the topoisomerase inhibitor camptothecin (CPT) into BNPs enhanced tumor cell uptake, bioadhesion within the tumor microenvironment, and prolonged intratumoral drug retention. Therefore, we investigated BNPs encapsulating CPT as a local, nonsurgical treatment for nodular squamous cell carcinoma (SCC) skin cancers in a mouse model. BNP-CPT treatment facilitated tumor destruction and resolution, and was compatible with local immunotherapy. These findings suggest that BNP delivery of antitumor agents may provide opportunities for nonsurgical treatment of nodular skin cancers like SCC.
Genome-wide role of codon usage on transcription and identification of potential regulators
Authors: Zhao Fangzhou , Zhou Zhipeng , Dang Yunkun , Na Hyunsoo , Adam Catherine , Lipzen Anna , Ng Vivian , Grigoriev Igor V. , Liu Yi 
Published: February 2021

Significance
Codon usage bias, the preference for certain synonymous codons, is a feature of all genomes and plays an important role in determining gene expression levels. Surprisingly, in addition to its role in mRNA translation, codon usage was recently shown to regulate gene expression at the transcriptional level. In this study, our results suggest that codon usage influences transcription genome-wide independently of its effect on translation. By carrying out a large-scale genetic screen, we identified 18 factors participating in multiple transcriptional regulatory mechanisms involved in the codon usage-mediated transcriptional effects. Together, our study establishes a foundation for future mechanistic understanding of this gene regulatory phenomenon.
The positioning of Japanese in a secondary CLIL science classroom in Australia
Authors: Turner Marianne 
Published: February 2021

Abstract
In Australia, content and language integrated learning (CLIL) is commonly implemented as a way to encourage
innovation in language teaching. This paper explores how Japanese can also be used to innovate the teaching of content.
Qualitative data are drawn from a Year 8 science Japanese CLIL classroom in a secondary school with an opt-in CLIL program. In the
class, a monolingual (in English) science teacher was co-teaching with a Japanese language teacher. Findings from observations,
after-class reflections, teacher and student interviews, a student survey and work samples revealed that students were highly
engaged with the Japanese component of their science lessons. Kanji was further positioned as a way for students to deepen their
understanding of scientific concepts. However, there also appeared to be a separation in the way both teachers and students spoke
about Japanese language use and learning science. Implications of these findings are discussed in the paper.
The interaction between timing of explicit grammar explanation and individual differences in second language
acquisition
Authors: Kachinske Ilina , DeKeyser Robert M. 
Published: February 2021

Abstract
Despite numerous positive findings of explicit instruction, this topic continues to engage scholars worldwide. One
issue that may be crucial for the effectiveness of explicit instruction is the interaction between cognitive individual
differences (language aptitude and working memory) and types of instruction. In this experiment, 128 learners of Spanish were
randomly assigned to four experimental treatments and completed comprehension-based practice for interpreting object-verb and
ser/estar sentences in Spanish. Results revealed that the various combinations of rules and practice posed differential task
demands on the learners and consequently drew on language aptitude and working memory to a different extent. We argue that not
only are rules and practice both necessary, but that their suitable integration ameliorates task demands, reducing the burden on
the learner, and accordingly mitigates the role of participants’ individual differences, thus making a substantial difference for
the learning of second language grammar.
Ethnolinguistic vitality and linguistic landscape
Authors: Pastor Alberto 
Published: February 2021

Abstract
Using a quantitative-method approach, a corpus of
photos of Linguistic Landscape texts taken in the most densely
populated Hispanic neighborhoods in Dallas (Texas) is analyzed in
search of indicators that allow us to gauge the ethnolinguistic
vitality of Spanish in the region. This research goal is
operationalized by studying the relative distribution of Spanish and
English in bilingual linguistic landscape texts; the symbolic and
informational meanings of each language; the representation of local
Spanish varieties, including phenomena related to language contact;
and the use or non-use of normative writing conventions. The
findings of this study augment our understanding of the impact of
existing language ideologies and attitudes towards local varieties
of Spanish on the prestige and utility of Spanish.
Urban discourse and civil resistance against gender-based
violence in Madrid
Authors: Molina Martos Isabel 
Published: February 2021

Abstract
Linguistic Landscape is analyzed to determine how
women’s voices come together in the urban space to ultimately become
a political movement. In recent years, women in Spain have been at
the front and center of an unprecedented mobilization against gender
inequality in all of its forms: salary gap, discrimination and
sexual violence, putting them at the leading edge of feminism
worldwide. I show how this political movement develops in Madrid. My
study is based on geosemiotics (Scollon & Scollon, 2003) and a qualitative
methodology is applied to understand how the social and political
action of protest is approached as mediated through texts and
signs.
Languages to buy and sell
Authors: Aijón Oliva Miguel A. 
Published: February 2021

Abstract
This chapter is concerned with linguistic
diversity in business names across the Spanish town of Salamanca.
Going from the urban center to the periphery, it examines three
areas that are relatively differentiated according to average
household income and immigrant population rate, among other
indicators. The analysis shows that the use of English and other
European languages is characteristic of the highly
commercially-oriented town center, while the most peripheral area
shows the emergence of Arabic and dialectal features of Latin
American Spanish, in line with recent migratory flows. Business
names in the intermediate area sometimes combine Spanish and English
features. The results are qualitatively interpreted as being
indexical of three different metaphorical directions of language
choice, namely outward, upward and
inward.