bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of tumour-associated tissue eosinophilia as a prognostic indicator in head and neck squamous cell carcinoma
Authors: Sharma Naveen , Salaria Neha , Kumar Surender , Thomas Nimmy , Beniwal Nidhi , Singh Ranvir 
Published: August 2021

Abstract
Background
Eosinophils are bone marrow-derived granulocytes known to have an imperative role in tissue inflammation. The mechanism of tumour-associated tissue eosinophilia (TATE) in head and neck cancers is however not well understood, and its role as a prognosticator is under evaluation. The aim of this study was to evaluate the association of TATE with factors associated with head and neck cancer and to assess its role as a prognostic marker in such patients.

Results
102 males and 24 females comprised the study population, and 34.9% of which were in the age group of 41 to 50 years. Amongst these 126 patients, most (37.3%) presented in stage III followed by stage IV (28.6%). 29.4% had well-differentiated SCC, 55.6% had moderately differentiated SCC, and 15% were diagnosed with poorly differentiated SCC. 42.8% had TATE grade II, followed by grade III (29.4%) and grade I (27.8%). Correlation studies showed that factors significantly associated with TATE were age, site and tumour differentiation. While 45.7% poorly differentiated tumours showed grade I eosinophilia, 51.4% of well-differentiated tumours had grade III TATE.

Conclusions
TATE showed a highly significant association with tumour differentiation, suggestive of eosinophils partaking a tumouricidal role. This association may be utilised as a convenient early prognosticator for head and neck cancers and should be made a regular feature of biopsy reports. Furthermore, it may be utilised in planning and adopting appropriate treatment modalities in malignancies predicted to have an aggressive course.
Association between house dust mites sensitization and level of asthma control and severity in children attending Mansoura University Children’s Hospital
Authors: Okasha Nahla Mohamed , Sarhan Amr Ali , Ahmed Engy Osman 
Published: August 2021

Abstract
Background
House dust mites (HDM) are considered as a major source of indoor aeroallergen all over the world that precipitate allergic reactions including rhinoconjunctivitis, food allergy, atopic dermatitis, and allergic asthma. In this study, we aimed to assess the clinical and laboratory profile of some Egyptian asthmatic children who are sensitized to house dust mites and determine the association of HDM sensitization and severity of asthma according to recent GINA guidelines.

Results
The most frequent clinical phenotype among the HDM-positive group was a cough (96.7%), while the clinical phenotypic wheeze was frequent in HDM negative group (96.7%). There is a statistically significant difference between studied cases classified according to sensitivity to HDM regarding level of asthma control (50.0% were uncontrolled among cases sensitive to HDM and 56.7% of cases non-sensitive to HDM were controlled (p = 0.001*). Severity according to treatment results was significantly higher among cases sensitive to HDM (26.7% of cases sensitive to HDM versus 3.3% of cases non-sensitive to HDM), p = 0.017.

Conclusions
HDM sensitization is associated mainly with cough asthma phenotype and allergic rhinitis in our studied cases. HDM sensitization increases asthma severity and decreases the ability to control asthma symptoms.

Trial registration
ClinicalTrial.gov, NCT04958616.
A Prospective Study of Early-pregnancy Thyroid Markers, Lipid Species, and Risk of Gestational Diabetes Mellitus
Authors: Wang Yi , Sun Fengjiang , Wu Ping , Huang Yichao , Ye Yi , Yang Xue , Yuan Jiaying , Liu Yan , Zeng Huayan , Wen Ying , Qi Xiaorong , Yang Chun-Xia , Wang Yixin , Liu Gang , Chen Da , Li Liangzhong , Pan Xiong-Fei , Pan An 
Published: August 2021

AbstractContextWhile the associations between thyroid markers and gestational diabetes mellitus (GDM) have been extensively studied, the results are inconclusive and the mechanisms remain unclear.ObjectiveWe aimed to investigate the prospective associations of thyroid markers in early gestation with GDM risk, and examine the mediating effects through lipid species.MethodsThis study included 6068 pregnant women from the Tongji-Shuangliu Birth Cohort. Maternal serum thyroid markers (free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone, thyroid peroxidase antibody, and thyroglobulin antibody) were measured before 15 weeks. Deiodinase activity was assessed by fT3/fT4 ratio. Plasma lipidome were quantified in a subset of 883 participants.ResultsMean age of the participants was 26.6 ± 3.7 years, and mean gestational age was 10.3 ± 2.0 weeks. Higher levels of fT4 were associated with a decreased risk of GDM (OR = 0.73 comparing the extreme quartiles; 95% CI 0.54, 0.98, Ptrend = .043), while higher fT3/fT4 ratio was associated with an increased risk of GDM (OR = 1.43 comparing the extreme quartiles; 95% CI 1.06, 1.93, Ptrend = .010) after adjusting for potential confounders. Multiple linear regression suggested that fT3/fT4 ratio was positively associated with alkylphosphatidylcholine 36:1, phosphatidylethanolamine plasmalogen 38:6, diacylglyceride 18:0/18:1, sphingomyelin 34:1, and phosphatidylcholine 40:7 (false discovery rate [FDR] adjusted P &lt; .05). Mediation analysis indicated 67.9% of the association between fT3/fT4 ratio and GDM might be mediated through the composite effect of these lipids.ConclusionLower concentration of serum fT4 or higher fT3/fT4 ratio in early pregnancy was associated with an increased risk of GDM. The association of fT3/fT4 ratio with GDM was largely mediated by specific lipid species.
Perceived caregiving preparedness and quality of life among Indonesian family caregivers of patients with life-limiting illness
Authors: Rochmawati Erna , Prawitasari Yuli 
Published: August 2021

Background: Family caregivers play an important role in palliative care. However, family caregivers often report that they felt insufficiently prepared to become a caregiver. This lack of preparedness may lead to a decline in the caregiver's quality of life (QoL), and they may not be able to provide sufficient palliative care to their family member. Aims: To investigate the preparedness of family members to become caregivers alongside their QoL. Method: A correlational cross-sectional study design was used. A sample of 104 family caregivers completed a World Health Organization Quality of Life Brief to assess the QoL of participants. The Caregiving Inventory (CGI) was used to assess how prepared family members felt to become care-givers, and the CGI also included questions related to the patient's socio-demographic status and illness. Correlation analysis was used to address the research questions. Caregivers were caring for a family member with a life-limiting illness in a suburban district of Indonesia. Findings: The 104 family caregivers had a relatively low score for both QoL and caregiving preparedness. A caregiver feeling more prepared was associated with a higher QoL. The study also found a positive correlation (r value, between 0.236–0.481) between perceived caregiving preparedness, including its factors, and domains of QoL. Conclusion: A person's preparedness to become a caregiver is significantly associated with all QoL domains: physical, psychological, social and environmental. Family members can be better prepared to become a caregiver with training and information about personal care and symptom management.
Anesthetic effectiveness of tekelan leaves on tinfoil barb fish in closed transportation
Authors: Ayuzar Eva , Rusydi Rachmawati , Muna Hayatun , Muliani Muliani 
Published: August 2021

The mortality of tinfoil barb during transportation is relatively high due to the oxygen consumption rate and excretion of these fishes. Therefore, the use of an appropriate anesthetic drug becomes one of the solutions for solving this transportation problem of tinfoil barb. One of the natural anesthetic drugs with potential to be studied is Chromolaena odorata leaves. The purpose of this study is to evaluate the effectiveness of anesthetic compounds from Chromolaena odorata leaves in the closed transportation of tinfoil barb. The experimental design used was a non-factorial completely randomized design that consisted of four treatments and three replications,then followed by a Tukey test to see if there was a significant difference. The experimental treatments were A (0 ml/L of leaves filtrate), B (80 ml/L of leaves filtrate), C (90 ml/L of leaves filtrate), and D (100 ml/L of leaves filtrate). The observed parameters were fish behavior towards unconscious condition, onset time, immotilization time, survival rate, and water quality. The results showed that the shortest onset time was obtained from treatment D (100 ml/L leaves filtrate), namely 58 minutes towards unconscious condition, then the longest immotilization time was also shown by treatment D, which was 371 minutes. The highest survival rates were also shown by treatment D which were 94,33% during transportation and 76,33% during culture. The water quality parameters during the experiment were in an optimum condition of tinfoil barb. Keywords:AnestheticChromolaenaodorataTransportationTinfoil barb
Characteristics of catfish oil, red palm oil and shark liver oil as functional foods
Authors: Amri Ulil , Diharmi Andarini , Sukmiwati Mery 
Published: August 2021

Functional food is a food ingredient in addition to basic needs as nutrients that can also play a functional role in health. This research aimed to determine the physicochemical characteristics and fatty acid composition of catfish oil, red palm oil, and shark liver oil as functional food ingredients. The research method was to extract fish oil from belly flap, purify catfish oil, and process red palm oil (RPO) from crude palm oil (CPO). The analysis parameters consisted of sensory analysis, oil chemical characteristics (free fatty acid analysis, peroxide, iodine, saponification, and acid numbers), total carotene, tocopherol, and analysis of fatty acid composition. The results showed that the catfish oil after being purified had sensory characteristics, smelled slightly fishy and semi-solid, and had a bright yellow color. The results of the analysis of chemical characteristics showed that the free fatty acid numbers of catfish oil and shark liver oil were following IFOS standards (1.33 and 0.62%), and the RPO numbers for peroxide and free fatty acids according to the SNI standards (9.56 meq kg and 1.44%). The highest ω-3 and ω- 6 fatty acids were in shark liver oil (3.56 and 35.35%), followed by catfish oil (1.72 and 19.9%). and RPO does not contain ω-3 and ω-6. Catfish oil, RPO, and shark liver oil act as functional foods. The fatty acid composition of catfish, shark liver and red palm oil contains saturated and the fatty acid composition of catfish, shark liver and red palm oil contains saturated and unsaturated fatty acids. Mono and poly unsaturated fatty acid (FUFA anf MUFA) in crude catfish oil, pure catfish oil, shark liver oil, and red palm oils were 56.71, 58.12, 63.81 and 47.39% respectively. The result of analysis showed composition of in catfish oil 1.72 and 19.9 %. The content of and of shark liver oil was 3.5 and 35.5%. Whereas in red palm oil does not Ω 3 and Ω 6. The content of EPA and DHA in shark liver oil was 0.08, 0.09 but not in catfish and red palm oil. The total content of carotene and tocopherol in red palm oil was 513.86 and 925.80 mg/kg, respectively. The nutritional composition of catfish oil, red palm oil, and shark liver oil has the potential to be used as functional food. Keywords:Characteristic physicochemicalCaroteneTocopherolω-3ω-6
Studying Shakespeare Adaptation: From Restoration Theatre to YouTube, Pamela Bickley and Jenny Stevens (2020)
Authors: Földváry Kinga 
Published: August 2021

Review of: Studying Shakespeare Adaptation: From Restoration Theatre to YouTube, Pamela Bickley and Jenny Stevens (2020)
The Arden Shakespeare, London and New York: Bloomsbury, 264 pp.,
ISBN 978-1-35006-864-3, h/bk, £65.00, p/bk, £19.99
The Administration of Hajj in Brunei under the British Residency (1906 – 1954): A Historical Perspective
Authors: Mobeen Bazilah 
Published: August 2021

This article explores the historical perspective of the administration of hajj in Brunei under the British Residency from 1906 until 1954. The pilgrimage reports were initially issued by the British and the British-Indian Officers. Malaysian pilgrims were previously misclassified as Javanese due to oversimplification of the officers in charge before the 1920s. Nevertheless, Bruneian pilgrims might interrelate with the same problem as they shared the same hajj routes. Eventually in the 1920s, the pilgrimage reports were mainly handled by the Malay Pilgrimage officer who was also known as the Malayan Pilgrimage Commissioner in 1948. The Malayan Pilgrimage Commissioner was responsible in handling the pilgrims from Brunei, Federation of Malaya, Sarawak, North Borneo, and Singapore during the pilgrimage season in Mecca at the time. Even though the Malayan Pilgrimage Commissioner eliminated the misclassification of Malaysian pilgrims, Bruneian pilgrims continued to be enumerated together with pilgrims from Malaysia under the rubric of ‘Malay Pilgrims’. Primary and secondary research method are conducted for this article where various primary and secondary sources related to the administration of hajj in Brunei from 1906 until 1954 are used. This article discusses the roles and duties of the British Residents, local officers, Malayan Pilgrimage Commissioner, Medical Officers, and Sheikh Haji (Hajj Sheikh) in the hajj administration of the pilgrims from Brunei. This article further analyses British interests behind their involvements in the hajj administration.
British Naval Power and its Influence on Indonesia, 1795–1942: An Historical Analysis
Authors: Carey Peter , Reinhart Christopher 
Published: August 2021

In Indonesian history, Britain has never been considered a prominent player in the politics of the archipelago. From an Indonesian perspective, the British presence only lasted a brief five years (1811–1816) during short-lived interregnum regime led by Thomas Stamford Raffles (1781-1826). This began with the British seizure of Java from the Franco-Dutch administration of Marshal Daendels (1808-11) and his successor, General Janssens (May-September 1811), and ended with the formal return of the colony to the Netherlands on 19 August 1816. However, as this article demonstrates, Britain has had a long-lasting and decisive influence on modern Indonesian history, dating from the time when the archipelago entered the vortex of global conflict between Britain and Republican France in the 1790s. The presence of the British navy in Indonesian waters throughout the century and a half which followed Britain’s involvement in the War of the First Coalition (1792-97) dictated inter alia the foundation of new cities like Bandung which grew up along Daendels’ celebrated postweg (military postroad), the development of modern Javanese cartography, and even the fate of the exiled Java War leader, Prince Diponegoro. in distant Sulawesi (1830-55). This British naval presence had pluses and minuses for the Dutch. On the one hand, it was a guarantor of Dutch security from foreign seaborne invasion. On the other, it opened the possibility for British interference in the domestic politics of Holland’s vast Asian colony. As witnessed in the 20th-century, the existence of the Dutch as colonial masters in the Indonesian Archipelago was critically dependent on the naval defence screen provided by the British. When the British lost their major battleships (Prince of Wales and Repulse) to Japanese attack off the east coast of Malaya on 10 December 1941 and Singapore fell on 15 February 1942, the fate of the Dutch East Indies was sealed. Today, the vital role played by the Royal Navy in guaranteeing the archipelago’s security up to February 1942 has been replaced by that of the Honolulu-based US Seventh Fleet but the paradoxes of such protection have continued.
Unreliable Accounts: How Regulators Fabricate Conceptual Narratives to Diffuse Criticism
Authors: Ramanna Karthik 
Published: August 2021

Abstract
In 2010, the U.S. accounting rulemaker (FASB) updated its longstanding constitution to eliminate “reliability” as a fundamental accounting property. FASB argued that “reliability” was misunderstood in practice and that this amendment clarified its original intent. Drawing on primary archival resources and field interviews with regulators, I provide evidence that the change also sought to legitimize the rise of fair-value accounting. By eliminating the need for accounting to be “reliable,” the change attempted to neutralize concerns about the subjectivity in fair-value estimates. Such subjectivity can facilitate accounting manipulation, and some fair-value rules can be attributed to lobbying by managers who stand to benefit. The change illustrates “conceptual veiling,” wherein regulators, seeking to diffuse criticism, including suspicions of capture, manufacture costly conceptual narratives for justifying their actions.
Cheap Talk with Multiple Experts and Uncertain Biases
Authors: Karakoç Gülen 
Published: August 2021

Abstract
A decision maker solicits information from two partially informed experts and then makes a choice under uncertainty. The experts can be either moderately or extremely biased relative to the decision maker, which is their private information. I investigate the incentives of the experts to share their private information with the decision maker and analyze the resulting effects on information transmission. I show that it may be optimal to consult a single expert rather than two experts if the decision maker is sufficiently concerned about taking advice from extremely biased experts. In contrast to what may be expected, this result suggests that getting a second opinion may not always be helpful for decision making.
From bench to bar side: Evaluating thered wine storage lesion
Authors: Klaschik Sven , Ellerkmann Richard K. , Gehlen Jennifer , Frede Stilla , Hilbert Tobias 
Published: August 2021

AbstractVitally essential red fluids like packed cells and red wine are seriously influenced in quality when stored over prolonged periods. In the case of red cell concentrates, the resultingstorage lesionhas particular significance in perioperative medicine. We hypothesized that, in contrast, aging rather improves the properties ofred winein several ways. A translational approach, including (I)in vitroexperiments, (II) a randomized, blinded crossover trial of acute clinical effects, and (III) a standardized red wine blind tasting was used. Three monovarietal wines (Cabernet Sauvignon, Chianti, Shiraz) in three different vintages (range 2004–2016), each 5 years different, were assessed. Assessments were performed at a German university hospital (I, II) and on a garden terrace during a mild summer evening (III). Young wines induced cell stress and damage while significantly reducing cytoprotective proteins in HepG2 hepatoma cells. Sympathetic activity and multitasking skills were altered depending on wines’ ages. Hangovers tended to be aggravated by young red wine. Aged variants performed better in terms of aroma and overall quality but worse in optical appearance. We found no evidence for ared wine storage lesion. However, we plead for consensus-based guidelines for proper storage, as it is common in clinical medicine.
Clonal diversity of the B cell receptor repertoire in patients with coronary in-stent restenosis and type 2 diabetes
Authors: Weng Ruiqiang , Liu Sudong , Gu Xiaodong , Zhong Zhixiong 
Published: August 2021

Abstract
Type 2 diabetes mellitus (T2DM) is known as a risk factor for coronary in-stent restenosis (ISR) in patients with coronary artery disease (CAD). Evidence suggests that B cells play a functional role in the progression of atherosclerotic lesions. However, the B cell receptor (BCR) repertoire in patients with ISR remains unclear. This study aims to profile the BCR repertoire in patients with coronary ISR/T2DM. A total of 21 CAD patients with or without ISR/T2DM were enrolled. PBMCs were isolated and examined for BCR repertoire profiles using DNA-seq. Our results showed that the diversity of amino acid sequences in ISR DM patients was higher than that in ISR −DM patients. The frequencies of 21 V/J paired genes differed between ISR DM and −ISR DM patients, while frequencies of 5 V/J paired genes differed between ISR DM and ISR −DM. The −ISR −DM group presented the highest clonotype overlap rate, while ISR DM patients presented the lowest overlap rate. Our study presented the BCR repertoires in patients with ISR/T2DM. The data suggested different BCR signatures between patients with ISR and T2DM. Further analysis of BCR profiles would enhance understanding of ISR.
Invasive ductal carcinoma and small lymphocytic lymphoma/chronic lymphocytic leukemia manifesting as a collision breast tumor: A case report and literature review
Authors: Chen Xiaowen , Chen Jianli , Liao Sihai , Cao Yuwen 
Published: August 2021

Abstract
Collision breast tumors, consisting of breast cancer (BC) and non-Hodgkin’s lymphoma (NHL), are extremely rare. Here we report the case of a 64-year-old woman with a collision tumor in her left breast mass that was composed of invasive ductal carcinoma and small lymphocytic lymphoma/chronic lymphocytic leukemia. In addition, we reviewed the published comparable English-language literature. Collision breast tumor composed of BC and NHL is extremely rare. For that reason, there is a lack of consensus about the underlying mechanism, and diagnosing it without delay remains a complex clinical challenge. We found that post-menopausal, age-related estrogen levels changes and Epstein-Barr virus infection are possible pathogenic factors. However, the symptoms are almost identical, and it is difficult to distinguish a simple breast tumor from a breast collision tumor. In this study, we reviewed the clinical features of all patients with BC and NHL colliding breast tumors; this information might enable early identification and prevention of misdiagnosis.