bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness and Safety of Micro‐Plasma Radiofrequency Treatment Combined With Autologous Chyle Fat Grafting Treatment for Hypertrophic Scars: A Retrospective Study
Authors: Zhang Peixuan , Pei Haina , Zhou Guiwen , Fu Qiang , Bai Ruiqi , Lin Pianpian , Wu Qian , Xu Xiao , Chen Minliang 
Published: December 2024

ABSTRACTBackgroundHypertrophic scar (HS) is a fibroproliferative disorder resulting from abnormal healing of skin tissue after injury. Although various therapies are currently employed in clinical to treat HSs, there is no widely accepted standard therapy. Micro‐plasma radiofrequency (MPR) and autologous chyle fat grafting are emerging treatments for this condition, and they have demonstrated promising therapeutic outcomes in clinical applications. The aim of this study is to investigate the effectiveness and safety of combining MPR with autologous chyle fat grafting for the treatment of HSs.MethodsWe performed a retrospective study on patients diagnosed with HS in a single center between January 2020 and December 2023. According to the treatments, patients were divided into three groups, with 6 months follow‐up. The single therapy group received MPR alone for two times. The combined therapy Group 1 first received the MPR treatment followed by the combined treatment. The combined therapy Group 2 first received the combined treatment and then received the MPR treatment. The effectiveness of treatment was evaluated using the Vancouver Scar Scale (VSS) and the Patient Scar Assessment Scale (PSAS). The Visual Analog Scale (VAS) was used to assess the patients' pain on the day of treatment and 1 day after treatment. Adverse events and complications were recorded to assess the safety of treatment.ResultsA total of 73 patients diagnosed with HS were enrolled in this study, including 35 patients in the single therapy group, 18 patients in the combined therapy Group 1, and 20 patients in the combined therapy Group 2. After the treatments were completed, all three groups exhibited significant effectiveness. The two combined therapy groups scored lower after treatments in the VSS, which includes height, vascularity, pliability, and total scores, as well as in the PSAS, which includes color, stiffness, thickness, and total scores, compared to the single therapy group, with a statistically significant difference. Regarding pain response to treatment, there was no statistical difference in VAS among the three groups. No statistical difference in the overall incidence of adverse events was observed among the three groups, and no severe complications were recorded.ConclusionsThis study revealed the combination of MPR and autologous chyle fat grafting showed superior effectiveness compared to MPR alone in treating HSs, without any observed increase in overall adverse event frequency. For patients diagnosed with HS, this combination therapy stands as a promising and effective clinical intervention.
Preparation and Evaluation of the Effectiveness of an Anti‐Wrinkle Cream Containing Equisetum arvense and Soybean Extracts
Authors: Nojomi Sara , Soltanmohammadi Fatemeh , Azimi Alamdari Hamideh , Hamedyazdan Sanaz , Mahmoudi Gharehbaba Adel , Javadzadeh Yousef 
Published: December 2024

ABSTRACTBackgroundSkin aging is a multifaceted condition marked by the development of wrinkles, reduced suppleness, and uneven pigmentation. Both endogenous and exogenous factors contribute to skin aging. Studies have examined the possible anti‐aging advantages of horsetail and soybean extracts, which are abundant in antioxidants.MethodsA study was conducted to develop and assess the stability of an anti‐wrinkle cream combining horsetail and soybean extracts over a period of 6 months. This study was a pilot study that was prospective and noncomparative in nature. An investigation was performed to explore the efficiency of a treatment on wrinkles on the forehead. The study involved 15 volunteers between the ages of 35 and 55, and the modified Fitzpatrick wrinkle grading scale (FWS) method was used to assess the results. The participants were directed to administer cream to the forehead region for a duration of eight sequential weeks. Images were acquired at the initial stage and after 8 weeks of treatment. An independent investigator evaluated the improvement in the overall appearance of the forehead skin by comparing clinical images taken before and after the therapy.ResultsThe cream exhibited exceptional stability, showing no noteworthy alterations in pH, viscosity, or microbiological count. The clinical findings demonstrated a notable decrease in the average FWS score from 8.7 ± 1.3 to 6.1 ± 1.8 (p < 0.005) after the treatment. 93.4% of the individuals experienced a positive alteration in the appearance of their forehead wrinkles.ConclusionThe formulated cream presents a hopeful method to tackle skin aging issues, backed by its durability and effectiveness in diminishing wrinkles. Additional investigation is necessary to clarify the underlying mechanisms.Trial Registration: IRCT20190917044799N1
Heteroglossic management in Instagram: Emerging ideological dynamics among Basque youth
Authors: Elordui Agurtzane 
Published: December 2024

AbstractIn this paper, I explore the monolingual and polylingual stylistic behaviors on Instagram among Basque native young people within the project Gaztesare. By means of an in‐depth qualitative study, I try to explain in which sense such monolingual and polylingual behaviors or styles are socially significant signs of difference (Gal & Irvine, 2019). The study reveals that those styles are organized in an axis of differentiation (Gal, 2016; Gal & Irvine, 2019) that takes the contrasting monolingual and polylingual styles as iconic representations linked to different personhoods or person‐types. The participants of the study consider them tools to shape and create contrasting voices that interilluminate each other in different contexts on Instagram. The study also informs about new ideological dynamics among these young people. In fact, the most innovative results in this study are about the enregisterment of the polylingual style I study. It is becoming an exclusive in‐group talk, and it is acquiring stereotypic indexical values related to informality. It is, moreover, being naturalized as a “social network speech” with which young people recreate multiple multicultural and playful voices.
The role of parents' and adolescents' critical reflection in the development of white youths' commitments to dismantling oppression
Authors: Suzuki Sara , Marchand Aixa D. , Johnson Sara K. 
Published: December 2024

AbstractGiven the access that white youth have to privilege and power, it is important to understand how they might develop life goals related to dismantling multiple forms of oppression, which we term critical purpose. Parents may support their children's critical purpose via their own critical reflection (understanding of the root causes of disparities in society), which may be associated with their child's critical reflection. Structural equation models of two waves of data from 351 white youth showed an indirect relationship between parent critical reflection and youth critical purpose through youth critical reflection. Bolstering white parents' critical reflection may be a strategy for supporting the development of white youths' commitments to future social justice action.
Racial discrimination and adverse childhood experiences predicting depressive symptoms and developmental assets: Testing cultural socialization and preparation for bias as moderators among Black adolescents and caregivers
Authors: Williams Chelsea Derlan , Bravo Diamond Y. , Santana Arlenis , Paige Roderick , Wise Cynara , Leslie Carine E. , Sullivan Terri N. 
Published: December 2024

AbstractThe current study examined whether adverse childhood experiences and racial discrimination predicted adolescents' internal developmental assets, external developmental assets, and depressive symptoms. We also tested whether these relations were buffered by aspects of caregivers' reports of ethnic‐racial socialization efforts (i.e., cultural socialization and preparation for bias). Participants were Black adolescents 12 to 17 years of age (Mage = 15.09, SD = 1.36) and their caregivers. Findings indicated that adolescents' racial discrimination experiences and adverse childhood experiences were associated with less internal assets, less external assets, and greater depressive symptoms. Preparation for bias was a protective moderator in two associations, such that at low levels of preparation for bias, racial discrimination predicted less external assets, but this relation became non‐significant at high levels of preparation for bias. Similarly, at low levels of preparation for bias, adverse childhood experiences predicted greater depressive symptoms, but this relation became non‐significant at high levels of preparation for bias. Caregivers' cultural socialization was also protective in that at low levels of cultural socialization, adverse childhood experiences predicted less internal developmental assets, but this relation became non‐significant at high levels of cultural socialization. Adverse childhood experiences and racial discrimination contribute to poorer outcomes, but caregivers' efforts to teach their children about their race, ethnicity, and culture are protective in some of these associations. Findings highlight that it is important to focus on both risk factors and protective family cultural processes to promote Black adolescents' positive developmental and mental health.
Medicare Advantage and rural hospital profitability
Authors: Kim Young H. , Reiter Kristin L. , Thompson Kristie W. , Pink George H. 
Published: December 2024

AbstractPurposeThis study compares 2018–2023 Medicare Advantage (MA) days as a percentage of total Medicare days in rural and urban hospitals, describes 2022–2023 operating profitability of rural and urban hospitals by quartiles of MA days as a percentage of total Medicare days, and explores hospital characteristics that may be important for understanding the relationship between MA and profitability of rural hospitals.MethodsFinancial and hospital data were obtained from the Centers for Medicare & Medicaid Services (CMS) Healthcare Cost Report Information System (HCRIS) for the years 2018 to 2023. Hospitals were assigned to quartiles based on MA days as a percentage of total Medicare days. Descriptive analyses were conducted to compare hospital characteristics and financial performance across quartiles.FindingsBetween 2018–2019 and 2022–2023, the median percentage of total Medicare days from MA grew from 11.3% to 28.0% for rural hospitals. The 2022–2023 median operating margin varied from 0.0% for rural hospitals in Q1 (lowest MA days as a percentage of total Medicare days) to 3.4% for hospitals in Q4 (highest MA days as a percentage of total Medicare days).ConclusionAmong rural hospitals, higher MA days as a percentage of total Medicare days was found to be associated with higher operating margin. However, results suggest that MA is not randomly distributed: rural hospitals with higher MA days as a percentage of total Medicare days exhibit distinct characteristics. This non‐random distribution suggests that descriptive analysis may not fully capture the actual financial impact of MA on rural hospitals. Future research should recognize these complexities.
Colocalization of Ellipsoid Zone Disruption With Capillary Nonperfusion in Different Retinal Vascular Layers and Choriocapillaris on En Face OCT of Diabetic Patients
Authors: Mirshahi Reza , Rahdar Amir , Ahmadi Mohamad Javad , Fadakar Kaveh , Torkashvand Ali , Nekoozadeh Shahbaz , Falavarjani Khalil Ghasemi 
Published: December 2024

ABSTRACTPurposeTo assess the colocalization of ellipsoid zone (EZ) disruption with nonperfusion in choriocapillaris (CC), retinal superficial capillary plexus (SCP), and deep capillary plexus (DCP) in diabetic patients using en face optical coherence tomography (OCT) and OCT angiography (OCTA).MethodsMacular OCT and OCTA scans (3 × 3 mm) of 41 patients with diabetic retinopathy were obtained using an RTVue XR Avanti instrument. After correcting the shadow artifacts, EZ integrity was assessed in the en face OCT slab using the Gaussian mixture model clustering method compared with the corresponding EZ en face OCT of 11 age‐matched normal patients. A similar technique was used for detecting capillary nonperfusion using CC en face OCTA. Geometric perfusion density (GPD) maps were also generated for the SCP and DCP. Maps of capillary nonperfusion in the CC, SCP, and DCP were compared pixel by pixel with the map generated from EZ disruption.ResultsTwenty‐one patients with diabetic macular edema (DME) and 20 patients with diabetic retinopathy without macular edema were included in this study. In both groups, the overlap of EZ disruption was significantly greater with choriocapillaris nonperfusion than with nonperfusion in the SCP and DCP (dry macular group: 33.15% with CC vs. 0.46% with SCP vs. 1.70% with DCP, p < 0.001; DME group: 29.81% with CC vs. 1.22% with SCP vs. 6.25% with DCP, p < 0.001). In multivariate analysis, after adjusting for stage of diabetic retinopathy and DME, EZ disruption was only associated with nonperfusion in CC (p value = 0.03). According to the linear regression model, there was a statistically significant correlation between logMAR visual acuity and EZ disruption in the dry macular group (p = 0.041).ConclusionIn patients with diabetic retinopathy, choriocapillaris nonperfusion may play a more significant role in photoreceptor loss than retinal nonperfusion.
Genomic investigation of plant secondary metabolism: insights from synteny network analysis of oxidosqualene cyclase flanking genes
Authors: Li Haochen , Li Jiale , Li Xinchu , Li Jialin , Chen Dan , Zhang Yangxin , Yu Qiaoming , Yang Fan , Liu Yunxiao , Dai Weidong , Sun Yaqiang , Li Pengmin , Schranz M. Eric , Ma Fengwang , Zhao Tao 
Published: December 2024

Summary
The clustered distribution of genes involved in metabolic pathways within the plant genome has garnered significant attention from researchers. By comparing and analyzing changes in the flanking regions of metabolic genes across a diverse array of species, we can enhance our understanding of the formation and distribution of biosynthetic gene clusters (BGCs).
In this study, we have designed a workflow that uncovers and assesses conserved positional relationships between genes in various species by using synteny neighborhood networks (SNN). This workflow is then applied to the analysis of flanking genes associated with oxidosqualene cyclases (OSCs). The method allows for the recognition and comparison of homologous blocks with unique flanking genes accompanying different subfamilies of OSCs.
The examination of the flanking genes of OSCs in 122 plant species revealed multiple genes with conserved positional relationships with OSCs in angiosperms. Specifically, the earliest adjacency of OSC genes and CYP716 genes first appeared in basal eudicots, and the nonrandom occurrence of CYP716 genes in the flanking region of OSC persists across different lineages of eudicots.
Our study showed the substitution of genes in the flanking region of the OSC varies across different plant lineages, and our approach facilitates the investigation of flanking gene rearrangements in the formation of OSC‐related BGCs.
A tripartite transcriptional module regulates protoderm specification during embryogenesis in Arabidopsis
Authors: Wang Chenchen , Gao Yang , Gong Wen , Laux Thomas , Li Sha , Xiong Feng 
Published: December 2024

Summary
Protoderm formation is a crucial step in early embryo patterning in plants, separating the precursors of the epidermis and the inner tissues. Although key regulators such as ARABIDOPSIS THALIANA MERISTEM LAYER1 (ATML1) and PROTODERMAL FACTOR2 (PDF2) have been identified in the model plant Arabidopsis thaliana, the genetic pathways controlling protoderm specification remain largely unexplored.
Here, we combined genetic, cytological, and molecular approaches to investigate the regulatory mechanisms of protoderm specification in Arabidopsis thaliana.
We report a novel role of the β‐importin KETCH1 in protoderm specification. KETCH1 loss‐of‐function leads to aberrant protoderm cell morphology and absent ATML1 transcription in embryos. We further demonstrate that KETCH1 directly interacts with an RNA Polymerase II (Pol‐II) cofactor JANUS, mediating its nuclear accumulation. Furthermore, JANUS directly interacts with the WUS HOMEOBOX2 (WOX2) protein, which is critical for WOX2‐activated ATML1 expression. Consequently, JANUS, KETCH1, and WOX2 loss‐of‐function results in similar protoderm defects.
Our results identify the tripartite KETCH1/JANUS/WOX2 transcriptional module as a novel regulatory axis in Arabidopsis protoderm specification.
The rhythm of horse gaits
Authors: Laffi Lia , Raimondi Teresa , Ferrante Carola , Pagliara Eleonora , Bertuglia Andrea , Briefer Elodie Floriane , Gamba Marco , Ravignani Andrea 
Published: December 2024

AbstractWhat makes animal gaits so audibly rhythmic? To answer this question, we recorded the footfall sound of 19 horses and quantified the rhythmic differences in the temporal structure of three natural gaits: walk, trot, and canter. Our analyses show that each gait displays a strikingly specific rhythmic pattern and that all gaits are organized according to small‐integer ratios, those found when adjacent temporal intervals are related by a mathematically simple relationship of integer numbers. Walk and trot exhibit an isochronous structure (1:1)—similar to a ticking clock—while canter is characterized by three small‐integer ratios (1:1, 1:2, 2:1). While walk and trot both show isochrony, trot has a slower tempo and is more precise and accurate, like a metronome. Our results quantitatively discriminate horse gaits based on rhythm, revealing striking commonalities with human music and some animal communicative signals. Gait and vocal rhythmicity share key features, and the former likely predates the latter; we suggest this supports gait‐based hypotheses for the evolution of rhythm. Specifically, the perception of locomotor rhythmicity may have evolved in different species under pressure for predator recognition and mate selection; it may have been later exapted for rhythmic vocal communication.
Translation, Reliability and Validity of the Chinese Version of the Confidence in Dementia Scale for Clinical Nursing: A Cross‐Sectional Study
Authors: Jiang Qianqian , Li Na , Kong Dong , Zhai Yan , Chen Haiwen , Liu Jinfeng , Xiao Ping , Chen Yanan , Pei Wenjian , Song Jie 
Published: December 2024

ABSTRACTAimTo translate the 9‐item Confidence in Dementia (CODE) scale into Chinese (Confidence in Dementia‐Chinese, CODE‐C) and evaluate its psychometric properties among clinical nurses.BackgroundWith the rapidly ageing population, an increasing number of patients with dementia will be cared for in hospitals. Clinical nurses' confidence in dementia care is crucial to provide quality care. A reliable and valid assessment tool is urgently needed to measure confidence in dementia and identify educational needs in hospitals. The CODE applies to other societies, and this study aims to standardise this scale for China.DesignThis was a cross‐sectional study.MethodsFollowing the principles of Brislin bidirectional translation, literal translation, back‐translation, expert consultation, cognitive debriefing and preliminary testing were performed, and the CODE‐C was preliminarily revised. Internal consistency and test–retest reliabilities with a 2‐week interval were tested, and an item analysis was conducted using the Pearson correlation coefficient method. Validity was evaluated, including content, construct, convergent, discriminant and criterion validity.ResultsA total of 452 Chinese‐speaking nurses from three hospitals in Jinan, China, completed the survey. The scores of each item and the total score of the CODE‐C were positively correlated (r = 0.626–0.802, p < 0.05). The difference between the high‐score group and the low‐score group for each item of the CODE‐C was significant (p < 0.05). The Cronbach's α coefficient, Spearman–Brown coefficient and Guttman split‐half coefficient of the CODE‐C were 0.894, 0.842 and 0.838, respectively, and the test–retest reliability was 0.892. The scale‐ and item‐level content validity indices were both 1.00. The confirmatory factor analysis model only marginally supported the three‐factor structure. Positive correlations were noted between the CODE‐C and the General Self‐Efficacy Scale (r = 0.476, p < 0.01), suggesting acceptable concurrent validity.ConclusionThe CODE‐C showed acceptable reliability and validity and can be applied to measure the level of confidence in dementia and the outcome of educational interventions aimed at enhancing dementia care among Chinese clinical nurses.Implications for PracticeThe CODE‐C can be used as a valid scale to assess the level of confidence in dementia among clinical nurses and help them recognise and improve their level of dementia care.
Early Improvement in Cardiac Function and Dyssynchrony After Physiological Upgrading in Pacing‐Induced Cardiomyopathy
Authors: Moraleda‐Salas María Teresa , Amigo‐Otero Emilio , Esteve‐Ruiz Irene , Arce‐León Álvaro , Carreño‐Lineros José Miguel , Torralba Elena Izaga , Roldan Francisco Navarro , Moriña‐Vázquez Pablo 
Published: December 2024

ABSTRACTBackgroundInterventricular dyssynchrony derived from the classic non‐physiological stimulation (n‐PS) of the right ventricle (RV) is a known cause of left ventricular dysfunction (LVDys).MethodsThis was a prospective descriptive single‐center study. We analyzed patients who develop LVDys with n‐PS, and the results after upgrading to conduction system pacing (CSP). Ultra‐high frequency electrocardiogram (UHF‐ECG) was performed pre and post‐implantation of the last patients included. ECG recordings in 16 frequency bands (150–1000 Hz) were used to create maps of ventricular depolarization. The maximum time difference between the centers of mass of the complex UHF QRS of leads V1–V6 (electrical dyssynchrony [DYS‐e] 16) and V1–V8 (DYS‐e 18) defined ventricular dyssynchrony. Data were expressed as mean ± standard deviation.Results27 patients were upgraded to CSP from January 2022 to January 2024 after developing LVDys. Permanent His bundle pacing (p‐HBP) was achieved in 63% (n = 17); in the other 10 patients left bundle branch area pacing (LBBAp) was performed. The average baseline LVEF improved from 34.5% (27–42) to 47.6% (38.2–57), p < 0.001. Telediastolic left ventricle diameter as well as QRS width also decreased. Thresholds remained stable at 6‐month follow‐up. The last eight patients included were studied in terms of ventricular synchrony parameters by UHF‐ECG (VDI Technologies), both His bundle pacing (HBP) and the LBBAp achieved significant improvement with respect to baseline parameters.ConclusionsLVEF improved in patients with previous n‐PS‐induced cardiomyopathy after upgrading to CSP. LVDys due to dyssynchronopathy is frequent and probably underdiagnosed. UHF‐ECG provides useful new information about ventricular activation and will likely improve patient selection for cardiac resynchronization therapy (CRT).
Managing a Mental Disorder With New Technologies: TheLeadless Pacemaker in Reel's Syndrome, a Case Report
Authors: Magliano P. L. , Scotto Di Uccio F. , Persico R. , Provvisiero C. , Ricciardi P. , Ducceschi V. 
Published: December 2024

ABSTRACTReel's syndrome (RS) is an unusual cause of pacemaker lead dislodgement. We present the case of a 59‐year‐old female patient with Down syndrome (DS) implanted with a dual‐chamber endovascular pacemaker due to symptomatic sinus node disfunction, reporting several syncopal episodes in last days and showing abnormal electrical parameters at the 2‐months follow‐up due to RS. The malfunctioning device was removed and an endocardial leadless pacing system was implanted.