bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monetary policy objectives and economic outcomes: What can we learn from a wavelet‐based optimal control approach?
Authors: Crowley Patrick M. , Hudgins David 
Published: November 2021

AbstractIt has recently been widely recognized that monetary policy objectives change through time as our understanding of monetary policy and its impact on the macroeconomy evolves. In recent years there has been an extensive review of the framework for monetary policy at major central banks around the world, given the practical problems that have been encountered with inflation targets. This paper is a contribution to this debate, in that the aim of this paper is to evaluate the consequences of adopting different monetary policy objectives in the U.S. macroeconomic policy setting. To accomplish this, we first decompose U.S. macroeconomic data using a time‐frequency domain technique, namely discrete wavelet analysis. We then model the behavior of the U.S. economy over each wavelet frequency range and use our estimated parameters to construct a tracking model. To illustrate the usefulness of this approach, we simulate jointly optimal fiscal and monetary policy with different short‐term monetary targets: an inflation target, a money growth target, an interest rate target, and a real economic growth target. The results show that the most effective monetary policy targets to achieve economic growth are either inflation targets or economic growth targets.
Maternal prenatal psychological distress associates with offspring early‐life wheezing – FinnBrain Birth Cohort
Authors: Puosi Emma , Korhonen Laura S. , Karlsson Linnea , Kataja Eeva‐Leena , Lukkarinen Heikki , Karlsson Hasse , Lukkarinen Minna 
Published: November 2021

AbstractBackgroundExposure to prenatal maternal psychological distress may contribute to the development of childhood atopic disorders. Little is known about the importance of distress severity and its duration for the risk. Our aim was to investigate how chronic maternal depressive and anxiety symptoms across gestation influence the risk of wheezing and eczema at child age 24 months.MethodsThe study population was drawn from the FinnBrain Birth Cohort Study, including 1305 mother‐infant dyads followed across gestation until the child age of 24 months when the outcomes were mother‐reported wheezing ever and doctor‐diagnosed eczema. To investigate the risk of wheezing phenotypes, wheezing with and without eczema was separated. Maternal distress was assessed with the Edinburgh Postnatal Depression Scale for depressive and the Symptom Checklist‐90 for anxiety symptoms three times during pregnancy, and the chronicity was demonstrated using symptom trajectories composed by latent growth mixture modeling.ResultsOf the children, 219/1305 (17%) had wheezing ever and 285/1276 (22%) had eczema. Risk of wheezing ever was elevated with maternal consistently high depressive symptoms (adjusted odds ratio 2.74; 95% confidence interval 1.37–5.50) or moderate and increasing anxiety symptoms (1.94; 1.06–3.54, respectively). Similarly, wheezing without eczema was associated with consistently high depressive (3.60; 1.63–7.94, respectively) and moderate and increasing anxiety symptoms (2.43; 1.21–4.91, respectively).ConclusionsMaternal chronic psychological distress across gestation was associated with toddler wheezing and especially wheezing without other atopic features (eczema). This finding supports the theory of intrauterine programming effect by maternal psychological distress on offspring immune system and respiratory morbidity.
Poetic Perlocutions: Poetry after Cavell after Austin
Authors: Mills Philip 
Published: November 2021

AbstractAlthough perlocution has received more interest lately, it remains the great unthought of Austin’s theory. The privilege he gives to illocution over perlocution, rather than being a necessity of his linguistic theory, is a contestable philosophical claim that leads him, I argue, to exclude from his consideration poetic and other ‘parasitical’ uses of language. Cavell’s reconceptualisation of perlocutions as ‘passionate utterances’, however, provides a more fruitful theoretical framework to approach poetic phenomena. Reading Austin through a Cavellian lens offers keys to make space for the parasitic uses Austin rejected and for poetry within a philosophy of language.
Does Direct Democracy Enhance Politicians’ Perceptions of Constituents’ Opinions? Evidence from Switzerland
Authors: Helfer Luzia , Wäspi Flurina , Varone Frédéric 
Published: November 2021

AbstractElected members of parliament (MPs) are supposed to represent their constituents and, thus, to have an accurate perception of citizens’ policy preferences. It is often assumed that direct democracy instruments, such as the popular initiative and the referendum, have a positive impact on MPs’ perceptual accuracy. This study assesses whether direct democracy has the expected positive effect in Switzerland. It measures how accurately MPs perceive their constituents’ opinions on a variety of policy proposals through a parallel survey of 97 national MPs and 4677 citizens. Empirical evidence shows that MPs perceive policy proposals that have been subjected to a direct democracy vote more accurately. Furthermore, MPs have a higher perceptual accuracy if the policy proposal submitted to a popular vote was conflictual with a narrow ballot outcome. Direct democracy thus fosters political representation as popular votes constitute an important source of information and sustain MPs’ ability to accurately assess citizens’ preferences.
Clinical benefits of a combined physician associate and senior specialist-led emergency surgery ambulatory emergency care clinic introduced in response to the COVID-19 pandemic
Authors: Edison Marie Alexandra , Waskett Bethan , Adekitan Daniel , Behar Nebil 
Published: November 2021

IntroductionA well-designed ambulatory emergency care (AEC) can alleviate demand for inpatient beds by reducing admissions or supporting early discharges. Increasing service demands and workforce gaps present major challenges to surgical departments. Physician’s associates (PAs) have been suggested as one way to address this, but previous barriers include lack of job role clarity, and inability to prescribe or request ionising radiation. An AEC clinic using PAs supported by senior decision-makers could improve patient care and provide workforce stability alongside a new capacity for successful PA positions.MethodsAn emergency surgery AEC pathway was introduced to a single centre in anticipation of a second COVID-19 wave. All emergency surgical referrals were prospectively collected over 3 months (November 2020 to February 2021) with minimum 30-day follow-up. The primary aims were to evaluate clinical outcomes and success of a new AEC PA role.ResultsA total of 175 patients were entered into the study. The median time from request for senior review to treatment decision was 26 min (IQR 9–62 min). The primary discharge rate was 38.3% (n=67), while the overall discharge rate without needing admission was 84% (n=147). Of the total 28 (16.0%) patients requiring admission, 18 (10.3%) were clinically appropriate. Four patients represented with Clavien-Dindo Grade II complications and above: two grade II (1.1%) and two grade IIIb respectively (1.1%). The role of the PA was well defined with no team discord. No patient complaints were received.ConclusionDuring the COVID-19 pandemic, an emergency surgery AEC pathway was implemented by combining a PA with a senior decision-maker, enabling fewer emergency admissions and significantly reduced time-to-reach-treatment decisions. This in turn facilitates bed-flow and minimises delays in patient treatment. The use of a well-defined PA role in this setting shows initial success and should be considered as a long-term role.
Non-linear composition and infinite conformal symmetry of topologically non-trivial solutions in $$(3+1)$$-dimensional Yang–Mills theory
Authors: Canfora Fabrizio 
Published: November 2021

AbstractAn infinite-dimensional family of analytic solutions in pure SU(2) Yang–Mills theory at finite density in $$(3+1)$$

(
3
+
1
)

dimensions is constructed. It is labelled by two integeres (p and q) as well as by a two-dimensional free massless scalar field. The gauge field depends on all the 4 coordinates (to keep alive the topological charge) but in such a way to reduce the (3+1)-dimensional Yang–Mills field equations to the field equation of a 2D free massless scalar field. For each p and q, both the on-shell action and the energy-density reduce to the action and Hamiltonian of the corresponding 2D CFT. The topological charge density associated to the non-Abelian Chern–Simons current is non-zero. It is possible to define a non-linear composition within this family as if these configurations were “Lego blocks”. The non-linear effects of Yang–Mills theory manifest themselves since the topological charge density of the composition of two solutions is not the sum of the charge densities of the components. This leads to an upper bound on the amplitudes in order for the topological charge density to be well-defined. This suggests that if the temperature and/or the energy is/are high enough, the topological density of these configurations is not well-defined anymore. Semiclassically, one can show that (depending on whether the topological charge is even or odd) some of the operators appearing in the 2D CFT should be quantized as Fermions (despite the Bosonic nature of the classical field).
Numerical Computations for Flow Patterns and Force Statistics of Three Rectangular Cylinders
Authors: Rahman Hamid , Shams-ul-Islam  , Abbasi Waqas Sarwar , Manzoor Raheela , Amin Fazle , Alam Zeeshan 
Published: November 2021

In this work, numerical simulations are performed in order to study the effects of aspect ratio (AR) and Reynolds number (Re) on flow characteristics of three side-by-side rectangular cylinders for fixed spacing ratio (

g

), using the lattice Boltzmann method (LBM). The Reynolds number varies within the range 60 ≤ Re ≤ 180, aspect ratio is between 0.25 and 4, and spacing ratio is fixed at

g

= 1.5. The flow structure mechanism behind the cylinders is analyzed in terms of vorticity contour visualization, time-trace analysis of drag and lift coefficients, power spectrum analysis of lift coefficient and variations of mean drag coefficient, and Strouhal number. For different combinations of AR and Re, the flow is characterized into regular, irregular, and symmetric vortex shedding. In regular and symmetric vortex shedding the drag and lift coefficients vary smoothly while reverse trend occurs in irregular vortex shedding. At small AR, each cylinder experiences higher magnitude drag force as compared to intermediate and large aspect ratios. The vortex shedding frequency was found to be smaller at smaller AR and increased with increment in AR.
Unsupervised Learning for Automated Detection of Coronary Artery Disease Subgroups
Authors: Flores Alyssa M. , Schuler Alejandro , Eberhard Anne Verena , Olin Jeffrey W. , Cooke John P. , Leeper Nicholas J. , Shah Nigam H. , Ross Elsie G. 
Published: November 2021

Background
The promise of precision population health includes the ability to use robust patient data to tailor prevention and care to specific groups. Advanced analytics may allow for automated detection of clinically informative subgroups that account for clinical, genetic, and environmental variability. This study sought to evaluate whether unsupervised machine learning approaches could interpret heterogeneous and missing clinical data to discover clinically important coronary artery disease subgroups.

Methods and Results
The Genetic Determinants of Peripheral Arterial Disease study is a prospective cohort that includes individuals with newly diagnosed and/or symptomatic coronary artery disease. We applied generalized low rank modeling and K‐means cluster analysis using 155 phenotypic and genetic variables from 1329 participants. Cox proportional hazard models were used to examine associations between clusters and major adverse cardiovascular and cerebrovascular events and all‐cause mortality. We then compared performance of risk stratification based on clusters and the American College of Cardiology/American Heart Association pooled cohort equations. Unsupervised analysis identified 4 phenotypically and prognostically distinct clusters. All‐cause mortality was highest in cluster 1 (oldest/most comorbid; 26%), whereas major adverse cardiovascular and cerebrovascular event rates were highest in cluster 2 (youngest/multiethnic; 41%). Cluster 4 (middle‐aged/healthiest behaviors) experienced more incident major adverse cardiovascular and cerebrovascular events (30%) than cluster 3 (middle‐aged/lowest medication adherence; 23%), despite apparently similar risk factor and lifestyle profiles. In comparison with the pooled cohort equations, cluster membership was more informative for risk assessment of myocardial infarction, stroke, and mortality.

Conclusions
Unsupervised clustering identified 4 unique coronary artery disease subgroups with distinct clinical trajectories. Flexible unsupervised machine learning algorithms offer the ability to meaningfully process heterogeneous patient data and provide sharper insights into disease characterization and risk assessment.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT00380185.
PRRX1 Loss‐of‐Function Mutations Underlying Familial Atrial Fibrillation
Authors: Guo Xiao‐Juan , Qiu Xing‐Biao , Wang Jun , Guo Yu‐Han , Yang Chen‐Xi , Li Li , Gao Ri‐Feng , Ke Zun‐Ping , Di Ruo‐Min , Sun Yu‐Min , Xu Ying‐Jia , Yang Yi‐Qing 
Published: November 2021

Background
Atrial fibrillation (AF) is the most common form of clinical cardiac dysrhythmia responsible for thromboembolic cerebral stroke, congestive heart failure, and death. Aggregating evidence highlights the strong genetic basis of AF. Nevertheless, AF is of pronounced genetic heterogeneity, and in an overwhelming majority of patients, the genetic determinants underpinning AF remain elusive.

Methods and Results

By genome‐wide screening with polymorphic microsatellite markers and linkage analysis in a 4‐generation Chinese family affected with autosomal‐dominant AF, a novel locus for AF was mapped to chromosome 1q24.2–q25.1, a 3.20‐cM (≈4.19 Mbp) interval between markers D1S2851 and D1S218, with the greatest 2‐point logarithm of odds score of 4.8165 for the marker D1S452 at recombination fraction=0.00. Whole‐exome sequencing and bioinformatics analyses showed that within the mapping region, only the mutation in the paired related homeobox 1 (
PRRX1
) gene, NM_022716.4:c.319C>T;(p.Gln107*), cosegregated with AF in the family. In addition, sequencing analyses of
PRRX1
in another cohort of 225 unrelated patients with AF revealed a new mutation, NM_022716.4:c.437G>T; (p.Arg146Ile), in a patient. The 2 mutations were absent in 908 control subjects. Biological analyses in HeLa cells demonstrated that the 2 mutants had significantly diminished transactivation on the target genes
ISL1
and
SHOX2
and markedly decreased ability to bind the promoters of
ISL1
and
SHOX2
(2 genes causally linked to AF), although with normal intracellular distribution.

Conclusions
This study first indicates that PRRX1 loss‐of‐function mutations predispose to AF, which provides novel insight into the molecular pathogenesis underpinning AF, implying potential implications for precisive prophylaxis and management of AF.
Kawasaki Disease May Increase the Risk of Subsequent Cerebrovascular Disease
Authors: Lin Chien-Heng , Lai Jung-Nien , Lee Inn-Chi , Chou I-Ching , Lin Wei-De , Lin Mei-Chen , Hong Syuan-Yu 
Published: November 2021

Background:
Previous epidemiological investigations examining the association between Kawasaki disease (KD) and cerebrovascular disease have had conflicting results. We analyzed the association between KD and cerebrovascular disease by conducting a population-based retrospective cohort study designed to investigate the hypothesis that KD could be a risk factor for subsequent cerebrovascular disease.

Methods:
From the National Health Insurance Research Database of Taiwan, the data of children (aged 0–18 years old) with KD (n=8467) were collected. Starting with the first year of study observation (referred to as the baseline year), data was collected for each child with KD, and 4 non-KD patients matched for sex, urbanization level of residence, and parental occupation were randomly selected to form the non-KD cohort (n=33 868) for our analysis. For the period from January 1, 2000, to December 31, 2012, we calculated the follow-up person-years for each patient, which is the time from the index date to the diagnosis of cerebrovascular disease, death, or the end of 2012. Furthermore, we compared the incidence, the incidence rate ratio, and the 95% CI of cerebrovascular disease between the KD and non-KD cohorts.

Results:
The overall cerebrovascular disease incidence rate was found to be 3.19-fold higher, which is significantly higher, in the KD cohort than in the non-KD cohort (14.73 versus 4.62 per 100 000 person-years), and the overall risk of cerebrovascular disease remained higher in the KD cohort (adjusted hazard ratio, 3.16 [95% CI, 1.46–6.85]). Furthermore, children aged <5 years showed a significantly higher risk of subsequent cerebrovascular disease in the KD cohort (adjusted hazard ratio, 3.14 [95% CI, 1.43–6.92]).

Conclusions:
This nationwide retrospective cohort study shows that KD may increase the risk of subsequent cerebrovascular disease, especially in those with KD aged <5 years old.
Radical Empiricism: William James and Gilles Deleuze
Authors: Stuhr John J. 
Published: November 2021

Abstract
Both William James and Gilles Deleuze labeled their philosophies "radical empiricism." In this context, this essay explores the similarities and differences between James's radical empiricism (particularly as it is present early inches Principles of Psychology) and Deleuze's "transcendental empiricism" (particularly as set forth in The Logic of Sense). These accounts then inform a view of philosophy understood as a creative art. This art demands flexible habits--what James termed "genius"--in a changing world. Accordingly, radically empirical accounts of creativity and genius are sketched.
Paradoxes of Pure Experience: From the Radical to the Transcendental with James and Deleuze
Authors: Duvernoy Russell J 
Published: November 2021

Abstract
This paper investigates the relationship between James’ radical empiricism and Deleuze’s study of the genesis of sense without a transcendental subject as necessary condition. It shows that James’ concept of pure experience changes the form of relation between mind and world. Considering how to conceptualize experience without a fixed metaphysical or transcendental subject destabilizes ontological identity, leads to a founding conceptual divergence from traditional phenomenology, and motivates Deleuze’s efforts towards transcendental empiricism. The paper reads Deleuze’s work on the genesis of sense in this context, arguing that one important result is an ontological pluralism. Such pluralism is crucial in considering how meaning can be made between and across differences and is in keeping with radical empiricism’s openness to life’s complexity.
The Need for a New Paradigm in International Law to Provide International Protection
Authors: Sarkin Jeremy Julian 
Published: November 2021

Abstract
Too little is provided, not only in international law, but also by the United Nations, for victims around the world. This article therefore argues that a new paradigm is needed. It uses the conflict in Syria since 2011, specifically focusing on how enforced disappearances and arbitrary detentions have been used, to examine these questions. It has been reported that at least 150,000 people have been affected by these practices, but the number may be as high as a million. Because the state has used these practices methodically, they amount to a widespread and systemic attack on the civilian population and, therefore, to crimes against humanity. While the Syrian regime is primarily responsible, non-state actors have also been committing these types of crimes. The article discusses the general processes that have been set up to deal with the conflict in international law and by the United Nations in places like Syria. It finds that very little has been done to end the conflict in Syria, other than mediation. The article then reviews the international processes dealing with disappearances and detentions in Syria that families can report to, and the role these institutions have played so far. It again finds that very little has been achieved. The article also examines other countries where processes have been set up to deal with missing and disappeared persons, such as Armenia, Azerbaijan, Bosnia-Herzegovina, Cyprus, and Georgia, to learn the lessons from these past processes for the Syrian situation. It is argued that, generally when mass atrocities occur, the UN on rare occasions will create an accountability process, but never creates a process that focuses on the needs of victims: finding their loved ones, getting them released from custody if they are alive, or finding the truth about what happened to them and where their remains are. The article therefore argues that a new mechanism is needed for Syria (but also for other places) to get people released, and to find information on others whose whereabouts are unknown due to the conflict and/or the mass human rights abuses. It contends that the mechanism could be set up by the UN, and if not, by a regional actor such as the European Union, or by several states. It is reasoned that the mechanism ought to have a Board made up of a representative each from the International Committee of the Red Cross (icrc), the International Commission on Missing Persons (icmp), the UN Working Group on Enforced or Involuntary Disappearances (wgeid), the UN Working Group on Arbitrary Detentions (wgad) and a Syrian organisation, elected each year.
A Central Voice in Caribbean Literature
Authors: van Dijk Yra , Kowsoleea Ghanima 
Published: November 2021

Abstract
This essay explores the complex ways in which narrative may signify in the contemporary Caribbean cultural context. Specifically, it is concerned with a trilogy written by award-winning Surinamese author Astrid Roemer, set in the years of independence of the Caribbean country after 300 years of Dutch occupation. The analysis focuses not on the usual postcolonial themes but on structures of signification: allegory, materiality and media of language, affect, and the function of objects. Roemer’s texts demonstrate the relation between discourse and physical violence, her language being tied to material media, bodies, and earth. Not just postmodern, but posthuman too, the Surinamese narrative is characterized by the attempt to connect objects to language, objects to emotions, or nature to memories. Language brings us in touch with Caribbean reality and memory, all the while questioning its capacity to do so through allegory and metaphor.