bluuebunny/crossref_metadata_2025_split huggingface dataset:
COSMIN Checklist for Systematic Reviews of the Hospital Preparedness Instruments in Biological Events
Authors: Aminizadeh Mohsen , Farrokhi Mehrdad , Ebadi Abbas , Masoumi Gholam Reza , Beyrami-jam Mehdi , Khankeh Hamid Reza 
Published: September 2021

Background and PurposeThe purpose of this research was to evaluate the psychometric properties of hospital preparedness instruments in biological events. The Consensus-based Standards for the selection of health Measurements Instruments (COSMIN) checklist has been used to design the appropriate hospital preparedness instruments in these events.MethodsA systematic search was performed in PubMed, Scopus, Web of Science and ProQuest, Google Scholar for relevant literature until December 31, 2018, and the data were extracted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality of the identified studies was assessed per measurement property according to the COSMIN checklist. Twenty studies that met the inclusion criteria were included.ResultsThe result showed that none of the evaluated checklists and instruments included all dimensions required for an appropriate hospital preparedness evaluation. The results revealed that none of the included studies reported adequate information on all the measurement properties of the instruments studied as per the COSMIN criteria.ConclusionsThe information on their measurement properties was lacking. Thus, there was a need for evaluating measurement. However, a vital necessity is felt for developing an instrument with acceptable psychometric properties for measuring hospital preparedness in biological events. The present study provided improved clarity about the quality of currently available hospital preparedness instruments in the biological event and the results of this systematic review could be used to prepare a standardized instrument to evaluate hospital preparedness in biological disaster.
Development and Testing of an Instrument for Summative Assessment of Practical Skill Performance: A Generalizability Theory Approach
Authors: Bjørk Ida Torunn , Larsen Karin , Ravik Monika , Reierson Inger Åse , Sommer Irene , Stenholt Britta , Brynildsen Grethe , Blomberg Karin , Bölenius Karin , Husebø Sissel Eikeland , Lämås Kristina , Hagtvet Knut Arne 
Published: September 2021

Background and PurposeMany newly graduated nurses lack proficiency in practical skill performance. Presently, nursing students’ practical skill is assessed by summative instruments with overarching items. The purpose of this study was to develop a more detailed instrument to use in summative assessment of nursing students’ practical skill performance and to assess its psychometric properties.MethodsA 50-item instrument was developed. Video-recorded performances were rated by experienced clinical supervisors. A multifacet measurement design was developed. Relevant parameters were estimated by generalizability analysis.ResultsFindings indicated that error of measurement were mainly caused by raters far more than by items. Conclusions: The present study suggested that summative assessment in realistic settings may not apply one rater only. Two to three/four raters appear necessary to dependably measure most skills.
Turkish Validity–Reliability of Breast Cancer Beliefs Scale and the Effect of Socio-Demographic Factors on Breast Cancer Beliefs
Authors: Aslan Hakime , Aktürk Ümmühan 
Published: September 2021

Background/aimThis study was conducted to determine the validity and reliability of the Breast Cancer Cultural Beliefs Scale for women with breast cancer in Turkish society.Materials and methodsThe population of this study was composed of patients diagnosed with breast cancer who were treated for cancer in the Adult Chemotherapy Unit. A total of 178 women with breast cancer participated in this study.ResultsIn order to determine the factor structure of the scale, principal component analysis was performed. Cronbach's alpha was used to determine the reliability of the scale scores. The results explained 62.93% of the total variance of the scale. The result of the Kaiser–Meyer–Olkin test was determined to be 0.813, and that of Bartlett's test was 723.56. Cronbach's alpha coefficient of the scale was .74.ConclusionIt was determined that the Breast Cancer Cultural Beliefs Scale was a valid and reliable tool for assessing the cultural beliefs of women in Turkey.
Psychometric Evaluation of the Oldenburg Burnout Inventory for Nursing Students
Authors: Bulfone Giampiera , Badolamenti Sondra , Biagioli Valentina , Maurici Massimo , Macale Loreana , Sili Alessandro , Vellone Ercole , Alvaro Rosaria 
Published: September 2021

BackgroundHigher education students, especially nursing students, have drawn more attention as a group that is vulnerable to the risk of developing burnout syndrome.PurposeTo test the psychometric properties of the Oldenburg Burnout Inventory in Nursing (OLBI-N).MethodsThe OLBI-N validity and reliability was tested in a sample of 476 nursing students. The validity was assessed with explorative and confirmative factor analyses. For hypothesis testing, we evaluated the correlation between burnout and academic self-efficacy.ResultsTwo factors (exhaustion and disengagement) were identified, and the confirmative factor analysis of the OLBI-N yielded a good fit. The OLBI-N was significantly correlated with academic self-efficacy (r = −0.37, 0.29, p < 0.01).ConclusionsThe OLBI-N is a valid, reliable questionnaire for measuring burnout among nursing students.
Adverse Childhood Experiences (ACEs): Development of an ACEs Knowledge Scale
Authors: Zhan Lin , Mou Xichen , Gill Marie 
Published: September 2021

Background and PurposeAdverse childhood experiences (ACEs) negatively impacting children’s health and later in their lives warrant necessity to educate nursing students about ACEs. The purposes of this study were to evaluate (a) nursing students' understanding of key concepts of ACEs using the ACEs Knowledge Scale (AKS) and (b) psychometric properties of the AKS.MethodsA survey using AKS was conducted with randomly selected student participants (n = 344) to evaluate students' understanding of ACEs knowledge. Empirical validation of the AKS included content validity using Content Validity Index (CVI), reliability, and construct validity analyses.ResultsThe results showed students in the Bachelor of Science in Nursing (BSN) program had increased knowledge of ACEs over pre-nursing students, and the BSN graduating students had increased knowledge related to trauma-informed care and building resilience. There were no significant differences in ACEs knowledge between Family Nurse Practitioner (FNP) and BSN students. Evaluation of psychometric properties of AKS revealed S-CVI/Ave=0.912, indicated excellent content validity based on the expert panel’s ratings. Cronbach’s alpha coefficient = .84 for the overall instrument indicated good reliability. Factor analyses were employed, showing that the 5-factor model gives good fit indexes, supporting the hypothesized factor structure of five key concepts.ConclusionsThe AKS has showed promising implications to future research, nursing education, and nursing practice.
Psychometric Properties of the Turkish Version of the Modified Engulfment Scale: Relation of Self-Concept
Authors: Kaşlı Seher , Bademli Kerime 
Published: September 2021

Background and PurposeModified Engulfment Scale (MES) measure the impact of a schizophrenic illness on an individual’s self-concept. The objective of this study was to determine psychometric properties of the Turkish form of MES (MES-T).MethodsThis cross-sectional study were included 162 schizophrenia patients with a convenience sampling method.ResultsBased on the results of factor analysis, five items were removed from the original version of the scale. It was determined that the MES-T consists of 25 items, and it has three factors: change in self-concept, belief in treatment, and future expectation. As a result of Pearson product-moment, low and moderate correlation coefficients were obtained between subscales, and moderate and high correlation coefficients were achieved between the subscales and total score of the scale.ConclusionsThe scale was found to be applicable for schizophrenia patients in Turkish population.
Management of the Patella During Total Knee Arthroplasty
Authors: Held Michael B. , Gazgalis Anastasia , Sarpong Nana O. , Geller Jeffrey A. , Shah Roshan P. , Cooper H. John 
Published: September 2021

» The optimal management of the patella during total knee arthroplasty (TKA) remains a controversial topic with no consensus.» Patellar management techniques during TKA include patellar retention or resurfacing with or without patellaplasty, as well as circumferential denervation and partial lateral facetectomy (PLF).» Special considerations such as patient age, etiology of disease, implant design, and surgeon preference should be accounted for when determining optimal management.» We recommend that most patellae be circumferentially denervated, regardless of whether they are resurfaced, as the potential benefits outweigh the small associated risks.» Evidence demonstrates improved functional outcomes with the addition of PLF to nonresurfaced patellae. There is currently a paucity of evidence of this technique with respect to resurfaced patellae.» Patellar resurfacing adds additional costs and health-care resources that should be considered in the decision-making process.
VERTEBRATE TAPHONOMY OF TWO UPPER MIOCENE BONEBEDS IN WESTERN PROTO-AMAZONIA (SOLIMÕES FORMATION, BRAZIL): INSIGHTS FROM MACROVERTEBRATE AND MICROVERTEBRATE FOSSILS
Authors: MUNIZ FELLIPE P. , BISSARO-JÚNIOR MARCOS CÉSAR , GUILHERME EDSON , DE SOUZA FILHO JONAS PEREIRA , NEGRI FRANCISCO RICARDO , HSIOU ANNIE S. 
Published: September 2021

ABSTRACTThe Niterói and Talismã sites comprise two of the most important fossiliferous deposits of the Neogene in Brazil. After 30 years of research, these sites have revealed rich assemblages of vertebrates and provided a glimpse of the Amazonian fauna and environment during the Miocene. Despite this, detailed studies that attempt to explain the genesis of these bonebeds are still scarce and hamper more robust paleoenvironmental and paleoecological reconstructions. Here we provide the first in-depth taphonomic analysis for both locations. Sedimentological and taphonomic evidence suggest that the depositional environments of Niterói and Talismã were similarly represented by shallow and calm waters in lacustrine/swampy contexts. We propose that the accumulation of bones and teeth is the result of attritional (day-to-day) mortality of organisms of the local community in a low sedimentation environment. The thanatocoenosis was exposed to biostratinomic processes for longer periods of time, which explains the high disarticulation, disassociation, fragmentation and loss of skeletal elements. The almost absence of weathering indicates that the aquatic environment slowed down the organic degradation of bioclasts, while the rarity of abrasion shows a limited influence of hydraulic flows in transporting and remobilizing bioclasts. Thus, both sites preserve mostly autochthonous to parautochthonous bioclasts, with a moderate level of time-averaging. Our results corroborate the hypothesis that lentic environments can present remarkable preservational conditions for the formation of attritional accumulations of vertebrate remains. Moreover, we show how the different collecting methods affect the description of preservational features and taphonomic interpretations of both fossil assemblages.
Characterization and Analysis of Anisotropic Relative Permeability
Authors: Pei Xuehao , Liu Yuetian , Gu Wenhuan , Jian Changsong 
Published: September 2021

Summary
The relative permeability functions of two-phase reservoirs are extensively used in modern reservoir-engineering theories for calculations and numerical simulations. In recent years, the theory of anisotropic reservoir development has advanced rapidly, and the anisotropic absolute permeability of reservoirs has been characterized and applied accurately. However, if only the anisotropy of absolute permeability is considered while neglecting the anisotropy of relative permeability, the effective permeability used in the calculations will differ significantly from that of an actual reservoir. In this study, an anisotropy experiment on two-phase relative permeability, with oil and water, was conducted using natural sandstone without fractures, which demonstrated the existence of anisotropy in relative permeability and analyzed its mechanism. The properties and calculation methods for anisotropic relative permeability were studied under the symmetry groups of a rhombic system. Numerical simulations of the reservoir considering anisotropic relative permeability were performed. The results demonstrated that the anisotropic relative permeability significantly affected the development of the oil reservoir, which is primarily indicated by the significant difference in the seepage direction of oil and water, and the complicated oil/water distribution. The results of this study differed significantly from the conventional understanding of remaining oil distribution. The deformed well pattern established for the anisotropy of the absolute permeability indicated a decrease in the oil-recovery ratio.
Effects of Free Range-of-Motion Upper Limb Exercise Based on Mirror Therapy on Shoulder Function in Patients After Breast Cancer Surgery: Study Protocol for a Randomized Controlled Trial
Authors: Yuan Ru Zhen , Li Kun Peng , Wei Xiao Lin , Zheng Wei , Ye Yi , Wang Ming Yue , Jiang Jie Ting , Wu Caiqin 
Published: September 2021

Abstract
Background Shoulder function complications are common after surgery for breast cancer. Quite a few survivors still reported a limited shoulder range of motion, even though the free range-of-motion upper limb exercise is helpful to restore shoulder function post-operatively. Mirror therapy(MT) is a classical and effective rehabilitation technique to recover motor and sensory function for limbs, in addition, studies have reported that MT has the influence on patients with shoulder functional dysfunction including increasing shoulder range of motion, improving shoulder function scores, and decreasing pain scores. Here we describe a protocol of a randomized controlled trial to explore if the free range-of-motion upper limb exercise based on mirror therapy has efficacy on shoulder function in breast cancer survivors after surgery.Methods/design This is a prospective, single-blind, two-arm randomized controlled trial. An estimated 70 participants will be randomly allocated to 1) MT group or 2) control group. The participants in the control group receive free range-of-motion upper limb exercise, and participants in the MT group will engages in free range-of-motion upper limb exercise based on mirror therapy. The intervention will start from the first day after surgery and will be completde at 8 weeks after surgery. Primary outcomes in this protocol is shoulder range of motion(ROM), while the Constant-Murley Score(CMS), Disability of arm, shoulder, and hand Questionnaire (DASH), Tampa Scale of Kinesiophobia (13-item TSK), Visual Analogue Scale(VAS), grip strength, arm circumference, and lypmphedema are secondary outcomes. Assessment will be conducted before allocation(baseline) and at 2 weeks, 4 weeks, and 8 weeks after surgery.Discussion Based on results that mirror therapy has influence on shoulder function immediately after intervention in patients without nerve injury, this randomized controlled trial is the first study to observe the efficacy of mirror therapy on shoulder function after a long time intervention in breast cancer survivors. We look forward the innovation of this study for both breast cancer rehabilitation and mirror therapy. Trial registration Chinese Clinical Trial Registry (ChiCTR): ChiCTR 2000033080. Registered on 19 May 2020, http://www.chictr.org.cn/searchproj.aspx.
Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer
Authors: Launonen Inga-Maria , Lyytikäinen Nuppu , Casado Julia , Anttila Ella , Szabó Angéla , Haltia Ulla-Maija , Jacobson Connor , Lin Jia-Ren , Maliga Zoltan , Santagata Sandro , Elias Kevin , D'Andrea Alan , Konstantinopoulos Panagiotis , Sorger Peter , Färkkila Anniina 
Published: September 2021

Abstract
The majority of high-grade serous ovarian cancers (HGSCs) are deficient in homologous recombination (HR) DNA repair, most commonly due to mutations or hypermethylation of the BRCA1/2 genes. We aimed to discover how BRCA1/2 mutations shape the cellular phenotypes and spatial interactions of the tumor microenvironment. Using a highly multiplex immunofluorescence and image analysis we generated spatial proteomic data for 21 markers in 124,623 single cells from 112 tumor cores originating from 31 tumors with BRCA1/2 mutation (BRCA1/2mut), and from 13 tumors without alterations in HR genes (HRwt). We identified a phenotypically distinct tumor microenvironment in the BRCA1/2mut tumors with evidence of increased immunosurveillance. Importantly, we found an opposing prognostic role of a proliferative tumor-cell phenotypic subpopulation in the HR-genotypes, which associated with enhanced spatial tumor-immune interactions by the CD8+ and CD4+T-cells in BRCA1/2mut tumors. The single-cell spatial landscapes indicate distinct patterns of spatial immunosurveillance with the premise to improve immunotherapeutic strategies and patient stratification in HGSC.
Bcl-xL Acts as an Inhibitor of IP3R Channels, Thereby Antagonizing Ca2+-Driven Apoptosis
Authors: Rosa Nicolas , Ivanova Hristina , II Larry Wagner , Kale Justin , Rovere Rita La , Welkenhuyzen Kirsten , Louros Nikolaos , Karamanou Spyridoula , Shabardina Victoria , Lemmens Irma , Vandermarliere Elien , Hamada Kozo , Ando Hideaki , Rousseau Frederic , Schymkowitz Joost , Mikoshiba Katsuhiko , Economou Anastassios , Tavernier Jan , Andrews David , Parys Jan , Yule David , Bultynck Geert 
Published: September 2021

Abstract
Anti-apoptotic Bcl-2-family members not only act at mitochondria but also at the endoplasmic reticulum, where they impact Ca2+ dynamics by controlling IP3 receptor (IP3R) function. Current models propose distinct roles for Bcl-2 vs Bcl-xL, with Bcl-2 inhibiting IP3Rs and preventing pro-apoptotic Ca2+ release and Bcl-xL sensitizing IP3Rs to low [IP3] and promoting pro-survival Ca2+ oscillations. We here demonstrate that Bcl-xL too inhibits IP3R-mediated Ca2+ release by interacting with the same IP3R regions as Bcl-2. Via in silico superposition, we previously found that the residue K87 of Bcl-xL spatially resembled K17 of Bcl-2, a residue critical for Bcl-2’s IP3R-inhibitory properties. Mutagenesis of K87 in Bcl-xL impaired its binding to IP3R and abrogated Bcl-xL’s inhibitory effect on IP3Rs. Single-channel recordings demonstrate that purified Bcl-xL, but not Bcl-xLK87D, suppressed IP3R single-channel openings stimulated by sub-maximal and threshold [IP3]. Moreover, we demonstrate that Bcl-xL-mediated inhibition of IP3Rs contributes to its anti-apoptotic properties against Ca2+-driven apoptosis. Staurosporine (STS) elicits long-lasting Ca2+ elevations in wild-type but not in IP3R-knockout HeLa cells, sensitizing the former to STS treatment. Overexpression of Bcl-xL in wild-type HeLa cells suppressed STS-induced Ca2+ signals and cell death, while Bcl-xLK87D was much less effective in doing so. In the absence of IP3Rs, Bcl-xL and Bcl-xLK87D were equally effective in suppressing STS-induced cell death. Finally, we demonstrate that endogenous Bcl-xL also suppress IP3R activity in MDA-MB-231 breast cancer cells, whereby Bcl-xL knockdown augmented IP3R-mediated Ca2+ release and increased the sensitivity towards STS, without altering the ER Ca2+ content. Hence, this study challenges the current paradigm of divergent functions for Bcl-2 and Bcl-xL in Ca2+-signaling modulation and reveals that, similarly to Bcl-2, Bcl-xL inhibits IP3R-mediated Ca2+ release and IP3R-driven cell death. Our work further underpins that IP3R inhibition is an integral part of Bcl-xL’s anti-apoptotic function.
Fusion of the SRDX Motif to OsPIL11 or OsPIL16 Causes Rice Constitutively Photomorphogenic Phenotypes In Darkness
Authors: Li Yaping , Zhang Fang , Zheng Chongke , Zhou Jinjun , Meng Xiangxue , Niu Shulin , Chen Fan , Zhang Hui , Xie Xianzhi 
Published: September 2021

Abstract
Dark-grown seedlings develop skotomorphogenically. Because of the development of rice direct seeding cultivation systems, there is an increasing need for clarifying the molecular mechanism underlying rice skotomorphogenic development. It has been reported that SRDX motif, LDLDLELRLGFA, was able to convert a transcriptional activator into a strong repressor. In the present study, to explore the functions of PILs in rice skotomorphogenesis, we generated OsPIL11-SRDX and OsPIL16-SRDX transgenic lines by fusing the SRDX transcriptional repressor motif to the C-terminal of two members of the phytochrome interacting factor-like (OsPIL) family in rice (OsPIL11 and OsPIL16). The OsPIL11-SRDX and OsPIL16-SRDX seedlings grown in darkness had constitutively photomorphogenic phenotypes with short coleoptiles and open leaf blades. The results of an RNA sequencing analysis revealed that the dark-grown OsPIL11-SRDX and OsPIL16-SRDX lines had gene expression patterns similar to those of wild-type seedlings grown under red light. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses indicated that the expression levels of genes related to photosynthesis, photosynthesis–antenna proteins, and porphyrin and chlorophyll metabolism were up-regulated in the dark-grown OsPIL11-SRDX and OsPIL16-SRDX lines, whereas the expression of genes related to the auxin pathway was down-regulated. In contrast, the expression levels of these photosynthesis-related genes were down-regulated in dark-grown transgenic seedlings overexpressing OsPIL11 or OsPIL16, which had exaggerated skotomorphogenesis. Considered together, our data indicate that OsPIL11 and OsPIL16 primarily function as transcriptional activators, at least in regards to promoting skotomorphogenesis and repressing the expression of photosynthesis-related genes.