bluuebunny/crossref_metadata_2025_split huggingface dataset:
Homologous recombination repair rathway and RAD54L in early-stage lung adenocarcinoma
Authors: Zheng Shaopeng , Yao Lintong , Li Fasheng , Huang Luyu , Yu Yunfang , Lin Zenan , Li Hao , Xia Jin , Lanuti Michael , Zhou Haiyu 
Published: February 2021

Objective
The current study aims to identify the dysregulated pathway involved in carcinogenesis and the essential survival-related dysregulated genes among this pathway in the early stage of lung adenocarcinoma (LUAD).

Patients and Methods
Data from The Cancer Genome Atlas (TCGA) including 526 tumor tissues of LUAD and 59 healthy lung tissues were analyzed to gain differentially expressed genes (DEGs). Gene ontology (GO) analysis was conducted with DAVID, while the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of DEGs was performed, followed by gene set enrichment analysis (GSEA) methods. Survival analysis was implemented in TCGA dataset and validated in Gene Expression Omnibus (GEO) cohort GSE50081, which includes 127 patients with stage I LUAD.

Results
GSEA enrichment analysis suggested that homologous recombination repair (HRR) pathway was significantly enriched. Subsequent KEGG pathway enrichment analysis indicated the significant up-regulation of HRR pathway in patients with T1 stage LUAD. Retrieved in Gene database, RAD54L is involved in HRR pathway and were recognized to be significantly differentially expressed in T1 stage LUAD in our study. The survival analysis indicated that high expression of RAD54L was significantly related to worse overall survival in patients with T1 stage LUAD (TCGA cohort: HR=2.10, 95% CI [1.47–2.98], P = 0.001; GSE50081 validation cohort: HR = 2.61, 95% CI [1.51–4.52], P = 0.002). Multivariate cox regression analysis indicated that RAD54L is an independent prognostic factor in the early-stage LUAD.

Conclusion
HRR pathway is up-regulated in LUAD, among which the expression of RAD54L was found to be significantly differentially expressed in T1 stage tumor tissue. Patients with high expression of RAD54L were associated with worse overall survival in the TCGA cohort and validation cohort. This study suggests a potential mechanism of lung cancer progression and provide a budding prognostic factor and treatment target in early-stage LUAD.
Lower Locus Coeruleus MRI intensity in patients with late-life major depression
Authors: Guinea-Izquierdo Andrés , Giménez Mónica , Martínez-Zalacaín Ignacio , del Cerro Inés , Canal-Noguer Pol , Blasco Gerard , Gascón Jordi , Reñé Ramon , Rico Inmaculada , Camins Angels , Aguilera Carlos , Urretavizcaya Mikel , Ferrer Isidre , Menchón José Manuel , Soria Virginia , Soriano-Mas Carles 
Published: February 2021

Background
The locus coeruleus (LC) is the major noradrenergic source in the central nervous system. Structural alterations in the LC contribute to the pathophysiology of different neuropsychiatric disorders, which may increase to a variable extent the likelihood of developing neurodegenerative conditions. The characterization of such alterations may therefore help to predict progression to neurodegenerative disorders. Despite the LC cannot be visualized with conventional magnetic resonance imaging (MRI), specific MRI sequences have been developed to infer its structural integrity.

Methods
We quantified LC signal Contrast Ratios (LCCRs) in late-life major depressive disorder (MDD) (n = 37, 9 with comorbid aMCI), amnestic Mild Cognitive Impairment (aMCI) (n = 21, without comorbid MDD), and healthy controls (HCs) (n = 31), and also assessed the putative modulatory effects of comorbidities and other clinical variables.

Results
LCCRs were lower in MDD compared to aMCI and HCs. While no effects of aMCI comorbidity were observed, lower LCCRs were specifically observed in patients taking serotonin/norepinephrine reuptake inhibitors (SNRIs).

Conclusion
Our results do not support the hypothesis that lower LCCRs characterize the different clinical groups that may eventually develop a neurodegenerative disorder. Conversely, our results were specifically observed in patients with late-life MDD taking SNRIs. Further research with larger samples is warranted to ascertain whether medication or particular clinical features of patients taking SNRIs are associated with changes in LC neurons.
Tissue inhibitor of metalloproteinase-1 (TIMP-1) as a prognostic biomarker in gastrointestinal cancer: a meta-analysis
Authors: Qin Lili , Wang Yueqi , Yang Na , Zhang Yangyu , Zhao Tianye , Wu Yanhua , Jiang Jing 
Published: February 2021

BackgroundTissue inhibitor of metalloproteinase 1 (TIMP-1) has recently been shown to be dependent on or independent of Matrix metalloproteinases (MMPs) in its roles in tumorigenesis and progression. This appreciation has prompted various studies assessing the prognostic value of TIMP-1 in patients with gastrointestinal cancer, however, the conclusions were still inconsistent. The aim of this study was to assess the prognostic value of TIMP-1-immunohistochemistry (IHC) staining and pretreatment serum/plasma TIMP-1 level in gastrointestinal cancer survival as well as the association between TIMP-1 and clinicopathologic features.MethodsThe meta-analysis was registered in the International Prospective Register of Systematic Reviews (PROSPERO; Registration NO. CRD42020185407) and followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. A highly sensitive literature search was performed in electronic databases including PubMed, EMBASE and the Cochrane Library. Heterogeneity analysis was conducted using both chi-square-based Q statistics and the I2test. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to assess the prognostic value of TIMP-1 using the fixed-effects model. Odds ratios (ORs) with 95% CIs were calculated to evaluate the associations between TIMP-1 and clinicopathological characteristics. The meta-analysis was conducted using STATA 12.0 software.ResultsA total of 3,958 patients from twenty-two studies were included in the meta-analysis. Elevated TIMP-1 levels were significantly associated with poor survival in gastrointestinal cancer (TIMP-1-IHC staining: HR = 2.04, 95% CI [1.59–2.61],I2 = 35.7%,PQ= 0.156; pretreatment serum/plasma TIMP-1 levels: HR = 2.02, 95% CI [1.80–2.28],I2 = 0%,PQ= 0.630). Moreover, clinicopathological parameter data analysis showed that elevated TIMP-1 levels were significantly associated with lymph node metastasis (N1/N2/N3 vs N0: OR = 2.92, 95% CI [1.95–4.38]) and higher TNM stages (III/IV vs I/II: OR = 2.73, 95% CI [1.23–6.04]).ConclusionBoth TIMP-1-positive IHC staining and high serum/plasma TIMP-1 levels are poor prognostic factors for the survival of gastrointestinal cancer. In addition, TIMP-1 overexpression was correlated with more advanced clinicopathological features.
Quantile-dependent expressivity of serum C-reactive protein concentrations in family sets
Authors: Williams Paul T. 
Published: February 2021

Background
“Quantile-dependent expressivity” occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g., C-reactive protein, CRP) is high or low relative to its distribution. We have previously shown that the heritabilities (h2) of coffee and alcohol consumption, postprandial lipemia, lipoproteins, leptin, adiponectin, adiposity, and pulmonary function are quantile-specific. Whether CRP heritability is quantile-specific is currently unknown.

Methods
Serum CRP concentrations from 2,036 sibships and 6,144 offspring-parent pairs were analyzed from the Framingham Heart Study. Quantile-specific heritability from full-sib (βFS, h2 ={(1 + 8rspouseβFS)0.5 − 1}/(2rspouse)) and offspring-parent regression slopes (βOP, h2 = 2βOP/(1 + rspouse)) were estimated robustly by quantile regression with nonparametric significance determined from 1,000 bootstrap samples.

Results
Quantile-specific h2 (±SE) increased with increasing percentiles of the offspring’s age- and sex-adjusted CRP distribution when estimated from βOP (Ptrend = 0.0004): 0.02 ± 0.01 at the 10th, 0.04 ± 0.01 at the 25th, 0.10 ± 0.02 at the 50th, 0.20 ± 0.05 at the 75th, and 0.33 ± 0.10 at the 90th percentile, and when estimated from βFS (Ptrend = 0.0008): 0.03±0.01 at the 10th, 0.06 ± 0.02 at the 25th, 0.14 ± 0.03 at the 50th, 0.24 ± 0.05 at the 75th, and 0.53 ± 0.21 at the 90th percentile.

Conclusion
Heritability of serum CRP concentration is quantile-specific, which may explain or contribute to the inflated CRP differences between CRP (rs1130864, rs1205, rs1800947, rs2794521, rs3091244), FGB (rs1800787), IL-6 (rs1800795, rs1800796), IL6R (rs8192284), TNF-α (rs1800629) and APOE genotypes following CABG surgery, stroke, TIA, curative esophagectomy, intensive periodontal therapy, or acute exercise; during acute coronary syndrome or Staphylococcus aureus bacteremia; or in patients with chronic rheumatoid arthritis, diabetes, peripheral arterial disease, ankylosing spondylitis, obesity or inflammatory bowel disease or who smoke.
Sexual violence victimization and suicide: Testing a coping‐mental health framework
Authors: Kaniuka Andrea R. , Desmarais Sarah L. , Cramer Robert J. , Stoner Julie E. , Veri Shelby , Wright Susan , Gemberling Tess M. , Nobles Matt R. , Holley Sarah R. 
Published: February 2021

AbstractSexual violence victimization is a prevalent public health concern. However, little research has investigated the factors linking sexual violence victimization to suicidal thoughts and behaviors (STBs). The current study tested the applicability of the psychological mediation framework, a coping‐mental health model, for the prevention of STBs among victims of sexual youviolence. Furthermore, the current study explored whether sexual orientation moderated the progression from sexual violence victimization to STBs. Data were drawn from an online survey of victimization experiences and health (N = 2175). Bootstrap mediation tested whether the association of sexual violence victimization and STBs was mediated by emotion regulation strategies (cognitive reappraisal and expressive suppression) and psychopathology (anxiety, depression, and posttraumatic stress disorder). Multiple‐groups analysis tested whether links within the mediation effects varied by sexual orientation. Bivariate findings showed that: (1) sexual minority persons were more likely to report sexual violence victimization and (2) cognitive reappraisal was more meaningfully associated with mental health among sexual minority persons. Sexual violence victimization was associated with STBs via a serial mediation through emotion regulation and psychopathology. The association between psychopathology and STBs was stronger among sexual minority compared with heterosexual respondents. Physical violence victimization was associated with STBs for heterosexual but not sexual minority persons in a follow‐up model. Findings support an emotion regulation‐mental health framework for the prevention of suicide among victims of sexual violence. Research and training implications are discussed.
Engineering Advanced In Vitro Models of Systemic Sclerosis for Drug Discovery and Development
Authors: De Pieri Andrea , Korman Benjamin D. , Jüngel Astrid , Wuertz‐Kozak Karin 
Published: February 2021

AbstractSystemic sclerosis (SSc) is a complex multisystem disease with the highest case‐specific mortality among all autoimmune rheumatic diseases, yet without any available curative therapy. Therefore, the development of novel therapeutic antifibrotic strategies that effectively decrease skin and organ fibrosis is needed. Existing animal models are cost‐intensive, laborious and do not recapitulate the full spectrum of the disease and thus commonly fail to predict human efficacy. Advanced in vitro models, which closely mimic critical aspects of the pathology, have emerged as valuable platforms to investigate novel pharmaceutical therapies for the treatment of SSc. This review focuses on recent advancements in the development of SSc in vitro models, sheds light onto biological (e.g., growth factors, cytokines, coculture systems), biochemical (e.g., hypoxia, reactive oxygen species) and biophysical (e.g., stiffness, topography, dimensionality) cues that have been utilized for the in vitro recapitulation of the SSc microenvironment, and highlights future perspectives for effective drug discovery and validation.
Understanding Photocapacitive and Photofaradaic Processes in Organic Semiconductor Photoelectrodes for Optobioelectronics
Authors: Paltrinieri Tommaso , Bondi Luca , Đerek Vedran , Fraboni Beatrice , Głowacki Eric Daniel , Cramer Tobias 
Published: February 2021

AbstractPhotoactive organic semiconductor substrates are envisioned as a novel class of bioelectronic devices that transduce light into stimulating biological signals with relevance for retinal implants or guided cellular differentiation. The direct interface between the semiconductor and the electrolyte gives rise to different competing optoelectronic transduction mechanisms. A detailed understanding of such faradaic or capacitive processes and the underlying material science is necessary to develop and optimize future devices. Here, the problem in organic photoelectrodes is addressed based on a planar p‐n junction containing phthalocyanine (H2Pc) and N,N′‐dimethyl perylenetetracarboxylic diimide (PTCDI). The detailed characterization of photoelectrochemical current transients is combined with spectroscopic measurements, impedance spectroscopy, and local photovoltage measurements to establish a model that predicts quantitatively faradaic or capacitive current transients. The decisive elements of the model are the energy levels present at the interface and the voltage building up in the photoelectrode. The result of the efforts is a comprehensive model of photocapacitive and photofaradaic effects that can be applied to developing wireless bioelectronic photostimulation devices.
Functionalized 2D Germanene and Silicene Enzymatic System
Authors: Chia Hui Ling , Sturala Jiri , Webster Richard D. , Pumera Martin 
Published: February 2021

AbstractIn recent years, 2D Group 14 graphane analogs, such as germanane, methyl germanane, and siloxene, have taken materials scientists by storm due to their facile synthesis procedures and the numerous attractive properties proffered. Due to their fascinating properties, these emerging Group 14 graphane analogs are studied for varied applications including supercapacitors, photocatalysts, and sensors. Although several groups have reported the viability of using Group 14 graphane analogs for the construction of biosensors, they are mainly based upon computational studies, and few experimental studies are conducted. This paper aims to experimentally investigate the feasibility of using germanane and siloxene‐based materials as 2D functional support for enzymatic systems. The heterogeneous electron transfer kinetics and the glucose sensing response of the as‐synthesized germanane, methyl germanane, and siloxene are examined, and the most outstanding material, germanane, is employed for further construction of electrochemical glucose biosensor. The fabricated biosensing platform delivers excellent analytical performances, displaying good linearity over various magnitudes of glucose concentrations, and possesses a low detection limit. The findings reported herein showcase the potential of applying these 2D Group 14 graphane analogs for future developments of highly selective and sensitive biosensors for biomedical, environmental monitoring, and food sampling applications.
Bioresorbable Metals for Biomedical Applications: From Mechanical Components to Electronic Devices
Authors: Ryu Hanjun , Seo Min‐Ho , Rogers John A. 
Published: February 2021

AbstractBioresorbable metals and metal alloys are of growing interest for myriad uses in temporary biomedical implants. Examples range from structural elements as stents, screws, and scaffolds to electronic components as sensors, electrical stimulators, and programmable fluidics. The associated physical forms span mechanically machined bulk parts to lithographically patterned conductive traces, across a diversity of metals and alloys based on magnesium, zinc, iron, tungsten, and others. The result is a rich set of opportunities in healthcare materials science and engineering. This review article summarizes recent advances in this area, starting with an historical perspective followed by a discussion of materials options, considerations in biocompatibility, and device applications. Highlights are in system level bioresorbable electronic platforms that support functions as diagnostics and therapeutics in the context of specific, temporary clinical needs. A concluding section highlights challenges and emerging research directions.
Polarization‐Sensitive Halide Perovskites for Polarized Luminescence and Detection: Recent Advances and Perspectives
Authors: Wang Xiaobo , Wang Yue , Gao Weiyin , Song Lin , Ran Chenxin , Chen Yonghua , Huang Wei 
Published: February 2021

AbstractWhile halide perovskites (HPs) have achieved enormous success in the field of optoelectronic applications, much attention has been recently drawn to the unique polarization sensitivity of HPs, either intrinsic or extrinsic, which makes HPs a potential candidate for innovative applications in directly polarized luminescence and detection. Herein, the research status in the field of polarization‐sensitive HPs, including linear polarization and circular polarization, is comprehensively summarized. To evaluate the effectiveness of HPs in generating and detecting linearly or circularly polarized light, the principles and characterization methods of polarized luminescence and detection are introduced. Sequentially, the state‐of‐the‐art development of the strategies that induce the linear or circular polarization characteristics of HPs is systematically reviewed, based on which the application of polarization‐sensitive HPs in the field of polarization luminescence and detection are summarized. Moreover, the current challenges and opportunities are discussed, and prospects of the future development in this promising field are outlined.
Manifesting Simultaneous Optical Spin Conservation and Spin Isolation in Diatomic Metasurfaces
Authors: Khaliq Hafiz Saad , Kim Inki , Kim Joohoon , Oh Dong Kyo , Zubair Muhammad , Riaz Kashif , Mehmood Muhammad Qasim , Rho Junsuk 
Published: February 2021

AbstractA novel design strategy that uses a di‐meta‐atomic platform to realize the unique chiroptical effect of simultaneous spin conservation and spin isolation at optical frequencies is demonstrated. The proposed strategy provides extra degrees of design freedom and encompasses the ability to encode a desired phase mask. The unit cell of the proposed single‐layered metaplatform includes a pair of achiral nanofins with distinct structural parameters. The mutual coupling of the nanofins yields constructive and destructive interferences in the absence of in‐plane and radial symmetries, and induces a giant linear chiroptical effect in the form of circular dichroism (CD) along with spin conservation. The optimized di‐meta‐atomic structure achieves 72% reflectance for the co‐polarized parameters of left‐handed circularly polarized (LCP) and 98% absorption of right‐handed circularly polarized (RCP) light with an extinction ratio of 70%. Hydrogenated amorphous silicon (a‐Si:H) is used to design and implement a di‐meta‐atomic‐based platform. The underlying mechanism and working principle for the proposed di‐meta‐atomic geometry are explained by multipole scattering. To validate this method, an encrypted metahologram is implemented; it verifies the concept of a spin‐conserved giant chiroptical effect and spin isolation.
Ultralow Threshold Optical Gain Enabled by Quantum Rings of Inverted Type‐I CdS/CdSe Core/Crown Nanoplatelets in the Blue
Authors: Delikanli Savas , Isik Furkan , Shabani Farzan , Baruj Hamed Dehghanpour , Taghipour Nima , Demir Hilmi Volkan 
Published: February 2021

AbstractAchieving low‐threshold optical gain for solution‐processed materials is crucial for their real‐life applications and deployment as gain media. However, the realization of low gain threshold in the blue region has shown to be technically an extremely challenging task using colloidal nanocrystals as a result of fast nonradiative Auger rates in smaller nanocrystals. Here, ultralow‐threshold blue amplified spontaneous emission (ASE) (≈2.7 µJ cm−2) accompanied with a large net modal gain coefficient of 360 cm−1 in the blue enabled by blue‐emitting (≈455–465 nm) colloidal quantum rings (QRs) of inverted type‐I CdS/CdSe core/crown nanoplatelets (NPLs) is proposed and demonstrated. The synthesized QRs with controlled crown size outperform the best reported ASE thresholds and net modal gain coefficients from the solution‐processed materials by ≈2.5‐ and ≈4‐fold, respectively, in the similar blue spectral window. Utilizing this QR architecture, it is also shown that the ASE peak can be spectrally tuned by controlling the lateral size of the crown and hence quantum confinement in the lateral direction. These outstanding results support the prospects of these solution‐processed QRs made of 2D hetero‐NPLs in the challenging blue region as colloidal gain.
A Self‐Healing Flexible Quasi‐Solid Zinc‐Ion Battery Using All‐In‐One Electrodes
Authors: Liu Jinyun , Long Jiawei , Shen Zihan , Jin Xing , Han Tianli , Si Ting , Zhang Huigang 
Published: February 2021

AbstractSelf‐healing and flexibility are significant for many emerging applications of secondary batteries, which have attracted broad attention. Herein, a self‐healing flexible quasi‐solid Zn‐ion battery composing of flexible all‐in‐one cathode (VS2 nanosheets growing on carbon cloth) and anode (electrochemically deposited Zn nanowires), and a self‐healing hydrogel electrolyte, is presented. The free‐standing all‐in‐one electrodes enable a high capacity and robust structure during flexible transformation of the battery, and the hydrogel electrolyte possesses a good self‐healing performance. The presented battery remains as a high retention potential even after healing from being cut into six pieces. When bending at 60°, 90°, and 180°, the battery capacities remain 124, 125, and 114 mAh g−1, respectively, cycling at a current density of 50 mA g−1. Moreover, after cutting and healing twice, the battery still delivers a stable capacity, indicating a potential use of self‐healing and wearable electronics.
Study of Electronic and Steric Effects of Different Substituents in Donor–Acceptor Molecules on Multilevel Organic Memory Data Storage Performance
Authors: Han Jinba , Lian Hong , Cheng Xiaozhe , Dong Qingchen , Qu Yongquan , Wong Wai‐Yeung 
Published: February 2021

AbstractTo study the influence of different types of substituent moieties onto the molecular backbones of conjugated donor–acceptor (D–A) molecules on the thin‐film morphology and performance of their memory devices, three new molecules X‐TBT were synthesized, which consist of the same backbone of two triphenylamine (T) groups and benzothiadiazole (BT) group, but have different substituents (X) with different electronic effects, that is, cyano group (CN), tert‐butyl group (tBu), and methoxy group (OMe). Nonvolatile ternary write‐once‐read‐many‐times (WORM) data storage behavior is achieved for the CN‐TBT and tBu‐TBT based devices as compared to the binary memory characteristic of TBT (X = H). In contrast, OMe‐TBT based device still maintains binary WORM behavior due to its unfavorable molecular packing motif and weak intermolecular charge transfer effect, but exhibits the lowest operating voltage (1.4 V) as a result of the lowest energy barrier between electrode and active layer. Notably, the tBu‐TBT based device displays the highest ION2/ION1/IOFF ratio of 107:103:1. Altering the substituents in D–A molecules can adjust the molecular packing, thin film morphology, and electron trap depth of the active layer, which then significantly influence the memory performance.