bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Osteoarthritis With Increased Risk of Parkinson's Disease: A Population‐Based, Longitudinal Follow‐Up Study
Authors: Feng Shih‐Hao , Chuang Hung‐Jui , Yeh Kuo‐Cheng , Pan Shin‐Liang 
Published: June 2021

ObjectiveTo investigate whether patients with osteoarthritis (OA) are at a higher risk of developing Parkinson's disease (PD).MethodsThis retrospective cohort study was conducted using Taiwan's Longitudinal Health Insurance Database 2005. We enrolled 33,360 patients who were 50–64 years old and had OA in 2002–2005 to form the OA group. The comparison group consisted of 33,360 age‐ and sex‐matched, randomly sampled subjects without OA. Then, their PD‐free survival curves were generated using the Kaplan‐Meier method. Multivariable Cox proportional hazards regression analysis was employed to estimate the effect of having OA on patients’ subsequent risk of PD.ResultsOf the 2 groups, the OA group had a significantly higher risk of developing PD (adjusted hazard ratio [HRadj] 1.41 [95% confidence interval (95% CI) 1.16–1.70], P = 0.0003). The PD‐free survival rate of the OA group was also significantly lower than that of the comparison group (P = 0.0004). The subgroup analysis showed that patients with knee or hip OA appeared to have a higher magnitude of PD risk (HRadj 1.55 [95% CI 1.14–2.11]) than patients with non–knee and non–hip OA (HRadj 1.42 [95% CI 1.06–1.89]) or with uncategorized OA (HRadj 1.32 [95% CI 1.05–1.64]).ConclusionOur findings suggest that OA is linked to an increased risk of developing PD.
Flexible Induction Heater Based on the Polymeric Thin Film for Local Thermotherapy
Authors: Saito Masato , Kanai Eiichi , Fujita Hajime , Aso Tatsuya , Matsutani Noriyuki , Fujie Toshinori 
Published: June 2021

AbstractLocal delivery of physical energy, such as heat, is promising for the treatment of target lesions without the unintended distribution of heat to other normal tissue. However, the heating device must be equipped with an external power source or strong magnetic field to operate the device, and many of them are too large to be placed inside the body. In this regard, wireless, lightweight, flexible electronics can be used for the miniaturization of implantable devices. In this study, a flexible induction heating (IH) device is reported that integrates inkjet‐printed wirings and flexible polymeric thin films, specifically Au nanoink‐based wirings (thickness: 1.5 µm) and a biodegradable poly(D, L‐lactic acid) (PDLLA) thin film (thickness: 5 µm). A unique method of transferring the inkjet‐printed Au nanoink wiring onto the PDLLA thin film realizes the integration of the following technical features in one device: biocompatible packaging, a printed IH system, and body conformability. The resulting thin‐film IH device is successfully placed on a hepatic lobe of a beagle dog, which allows for a local increase in temperature of 7 °C after 1‐min power feeding without tissue inflammation. The thin‐film IH device is expected to provide minimally invasive thermotherapy when combined with endoscopic surgery.
Toward High Performance All‐Solid‐State Lithium Batteries with High‐Voltage Cathode Materials: Design Strategies for Solid Electrolytes, Cathode Interfaces, and Composite Electrodes
Authors: Li Liansheng , Duan Huanhuan , Li Jia , Zhang Lei , Deng Yuanfu , Chen Guohua 
Published: June 2021

AbstractAll‐solid‐state lithium batteries (ASSLBs) with nonflammable solid electrolytes (SEs) deliver greatly enhanced safety characteristics. Furthermore, ASSLBs composed of cathodes with high working voltages, such as LiCoO2, LiNixCoyMnzO2 (x + y + z = 1, NCM), LiNixCoyAlzO2 (x + y + z = 1, NCA), LiMnxFeyPO4 (x + y = 1, LMFP), and LiNi0.5Mn1.5O4 (LNMO), and a lithium metal anode can achieve comparable or better performance compared with that of LLBs in terms of energy density. Therefore, high‐voltage ASSLBs have been regarded as the most promising next‐generation batteries. Although significant progress has been achieved in high‐voltage ASSLBs research, their development still faces multiple challenges. To facilitate further effective and target‐oriented research on high‐voltage ASSLBs, a summary of recent research progress is urgently needed. In this review, recent research progress in high‐voltage ASSLBs is summarized from the perspectives of SEs modification, interfacial challenges and their corresponding solutions for cathodes, and high‐voltage composite cathode design for practical applications. Finally, the authors’ perspectives on the state of current ASSLBs research, aiming to propose possible research directions for the future development of high‐voltage ASSLBs.
IR Spectroscopy as a Method for Online Electrolyte State Assessment in RFBs
Authors: Nolte Oliver , Geitner Robert , Hager Martin D. , Schubert Ulrich S. 
Published: June 2021

AbstractThe transition from fossil to renewable energy sources requires adequate storage technologies due to the intermittency of the supplied energy. With respect to this, organic redox‐flow batteries (ORFBs) represent a promising concept for the storage of electricity on a large scale at economically justifiable costs. However, these storage technologies can only be operated reliably if parameters representing the actual condition of the storage medium (i.e., the electrolyte) can be accurately assessed. These so‐called electrolyte state variables are represented by two key figures of merit: state of charge (SOC), a measure of the amount of charge that the electrolyte currently holds; and state of health (SOH), representing the amount of charge that the electrolyte is able to store given its current condition. The herein presented IR‐based approach is able to simultaneously provide reliable, fast, accurate, and precise estimates for both SOC and SOH parameters at any point in time and independent of the current battery status. The method is able to provide a time resolution in the range of minutes, is independent of the electrolyte temperature and can be applied to nearly all organic‐based redox‐active materials and solvents, while potentially being applicable to inorganic RFBs, such as vanadium‐based systems, as well.
Utilization of heat‐mapping tools to match a resident staffing template to emergency department arrival patterns
Authors: Schuh Abigail M. , Nimmer Mark , Drendel Amy L. 
Published: June 2021

AbstractObjectivesAcademic emergency departments (ED) rely on a steady flow of patients to provide residents with good clinical training. Understanding institutional volume patterns allows training directors to create a schedule that maximizes learning opportunities while also adequately staffing the ED. Our primary objective of this study was to utilize heat‐mapping software to optimize resident staffing in an academic ED.MethodsHeat‐mapping tools within Microsoft Excel were utilized to overlay ED patient arrival patterns on top of the potential patients per hour based on published productivity data for trainees and historical averages for advanced practice providers at our institution. Time frames for under‐ and overstaffing were identified and color‐coded. This analysis informed a revised schedule template and the same heat‐mapping process was used to determine the appropriateness of the revised staffing template.ResultsThe heat map for the original schedule template revealed understaffing in the morning and overstaffing the rest of the day. Informed by these findings, schedule adjustments were made. There was no net increase in the number of resident or advanced practice provider coverage hours. Prior to implementation, the ED was understaffed by 5% or more during 18.4% of operating hours. Following changes to the staffing template, only 5.9% of operating hours were understaffed (p < 0.001). Furthermore, significant understaffing (20% or more) decreased from 16.6% to 3.1% (p < 0.001).ConclusionsNovel use of heat‐mapping software has the potential to successfully match ED patient arrival patterns to an optimal resident staffing template. Future directions include incorporation of variable resident productivity to account for fatigue as the shift progresses.
Water in Organic Solvents: Rapid Detection by a Terbium‐based turn‐off Luminescent Sensor
Authors: Kumar Ajay , Sahu Manaranjan , Maitra Uday 
Published: June 2021

AbstractReactions carried out both in protic and aprotic water‐miscible solvents can be affected by the presence of water. We have recently discovered that the luminescence intensity of a methanolic solution of Tb(III) containing salicylic acid [Tb−SA] is highly sensitive to the water content. The water‐induced quenching of Tb(III) luminescence was utilized for the accurate measurement of water content in methanol, ethanol, acetonitrile, and tetrahydrofuran in the 0.1%–4% (v/v) range by a simple and rapid method.
Funktionales Kostensplitting bei energetischen Modernisierungen als Beitrag zur nachhaltigen Entwicklung von Mietwohnbeständen
Authors: David Kirsten 
Published: June 2021

AbstractIn einer Ende 2019 veröffentlichten Dissertation wurde mit dem Funktionalen Kostensplitting (kurz: ƒKs) eine Handlungsempfehlung zur sachgerechten und nachvollziehbaren Ermittlung Mieterhöhungen nach energetischen Maßnahmen entwickelt.Ausgangspunkt war das Dilemma zwischen der enormen Bedeutung energetischer Maßnahmen an Mietwohnbeständen für die klimapolitischen Ziele einerseits und andererseits den widersprüchlichen Beschreibungen ihrer Wirtschaftlichkeit für die beiden Mietervertragsparteien – zwischen Gentrifizierungsinstrument und Warmmietenneutralität.Die Ergebnisse der Forschungsarbeit schließen nicht nur eine Lücke in der interdisziplinären Wissenslandschaft der Akteure des Mietwohnungsmarktes. Mit der daraus abgeleiteten Handlungsempfehlung des ƒKs wurde zudem erstmals der bautechnische Erfolg energetischer Maßnahmen – die tatsächlichen Verbesserungen der Bauteilfunktionen – an den nach geltendem Recht resultierenden Mieterhöhungsbetrag gekoppelt. Auf diese Weise wird das Zieldreieck der Nachhaltigkeit aus Ökonomie, Ökologie und Sozialem energetischer Maßnahmen austariert.Die Arbeit wurde vom Wissenschaftlichen Beirat des BUND mit dem BUND‐Forschungsreis für nachhaltige Entwicklung 2020 ausgezeichnet.Im vorliegenden Aufsatz werden Grundlagen und Arbeitsweise des ƒKs sowie erste Ergebnisse einer noch andauernden qualitativen Evaluation vorgestellt.
Automatic Migration Path Exploration for Multivalent Battery Cathodes using Geometrical Descriptors
Authors: Bölle Felix T. , Bhowmik Arghya , Vegge Tejs , Maria García Lastra Juan , Castelli Ivano E. 
Published: June 2021

AbstractStable and fast ionic conductors for magnesium cathode materials have the prospect of enabling high energy density batteries beyond current Lithium‐ion technologies. So far, only a few candidate materials have been identified leading to data only being scarcely available to the community. Here, we present a systematic study, in the framework of Density Functional Theory, including the estimation of the migration barrier for 16 materials through employing Nudged Elastic Band (NEB) calculations. By introducing a path finder algorithm based on the idea of Voronoi tessellations, we show that an estimate of the transition state configuration can be extracted automatically prior to running NEB‐calculations. Using geometrical descriptors in combination with a principal component analysis it is possible to further sub‐group the migration paths. This approach also extends to materials which are not part of the study, making it a viable approach to more efficiently explore crystal structures with distinguishable migration characteristics.
Exploring the toxic effects and mechanism of methoxylated polybrominated diphenyl ethers (MeO‐PBDEs) on thyroxine‐binding globulin (TBG): Synergy between spectroscopic and computations
Authors: Huang Muwei , Huang Xiaomei , Zuo Yanqiu , Yi Zhongsheng , Liu Hongyan 
Published: June 2021

AbstractThe interaction mechanism between thyroxine‐binding globulin (TBG) and three methoxylated polybrominated diphenyl ethers (MeO‐PBDEs) was analyzed by steady‐state fluorescence, ultraviolet‐visible (UV‐visible) spectroscopy, circular dichroism (CD), molecular docking and molecular dynamics simulation methods. The results of the molecular docking technique revealed that 2′‐MeO‐BDE‐3, 5‐MeO‐BDE‐47, and 3‐MeO‐BDE‐100 combined with TBG at the active site. The steady‐state fluorescence spectra displayed that MeO‐PBDEs quenched the endogenous fluorescence of TBG through static quenching mechanism, and complex formation between MeO‐PBDEs and TBG was further indicated by UV‐vis spectroscopy. The thermodynamic quantities showed that the binding process is spontaneous, and the major forces responsible for the binding are hydrogen bonding and hydrophobic interactions, which are consistent with the results of molecular docking to a certain extent. The results of CD confirmed that the secondary structure of TBG was changed after combining with MeO‐PBDEs. The dynamic simulation results illustrated that the protein structure is more compact and changes in the secondary structure of TBG after binding to MeO‐PBDEs. Additionally, we also utilized the molecular mechanics/Poisson–Boltzmann surface area (MM‐PBSA) method to analyze the binding free energy of TBG and MeO‐PBDEs. The results suggest that van der Waals force plays an essential role in the combination.
Entrepreneurial versus cooperative social capital: The impact on operational performance
Authors: Bonner Aisling , Onofrei George , Humphreys Paul , Margey Michael , Cadden Trevor 
Published: June 2021

AbstractResearch has extensively focused on how firms can become more competitive, by discovering new knowledge domains while exploiting current ones. Prior research has shown the positive impact of social capital on performance; however, there have been no empirical studies that distinguished between the architectures of social capital and how they impact the operational performance dimensions. Building upon the knowledge‐based theory, we propose a model to examine the effects of the two architectures of social capital (entrepreneurial and cooperative) on individual dimensions of operational performance (quality, delivery, flexibility and cost). The hypotheses are tested using structural equation modelling and data collected from 182 companies in Ireland. The results show that the cooperative social capital archetype supports the operational performance dimensions, while the entrepreneurial social capital archetype only impacts the cost dimension. The findings extend the current understanding about the complex relationships among the architectures of social capital and provide guidance for managers on how to leverage their investments in social capital to enhance specific operational performance dimensions.
Prefiltration enhances performance of sterile filtration for glycoconjugate vaccines
Authors: Du Zhuoshi , Motevalian Seyed Pouria , Carillo‐Conde Brenda , Reilly Kelvin , Zydney Andrew L. 
Published: June 2021

AbstractRecent studies have reported very low capacity during sterile filtration of glycoconjugate vaccines due to rapid fouling of the sterile filter. The objective of this study was to explore the potential for significantly increasing the capacity of the sterile filter through the use of an appropriate prefilter. Data were obtained using prefilters with different pore size and chemistry, with the sterile filtration performed at constant filtrate flux using 0.22 μm nominal pore size Durapore® polyvinylidene difluoride membranes. Prefiltration through 5 μm pore size Durapore® or Nylon prefilters nearly eliminated the fouling of the sterile filter, leading to more than a 100‐fold reduction in the rate of pressure increase for the sterile filter. This dramatic improvement in sterile filter performance was due to the removal of large components (greater than 1 μm in size) as confirmed by dynamic light scattering. These results demonstrate the potential of using large pore size prefilters to significantly enhance the performance of the sterile filtration process for the production of important glycoconjugate vaccines.
Effect of iron addition on mAb productivity and oxidative stress in Chinese hamster ovary culture
Authors: Graham Ryan J. , Mohammad Adil , Liang George , Fu Qiang , Kuang Bingyu , Polanco Ashli , Lee Yong Suk , Marcus R. Kenneth , Yoon Seongkyu 
Published: June 2021

AbstractTrace metals play a critical role in the development of culture media used for the production of therapeutic proteins. Iron has been shown to enhance the productivity of monoclonal antibodies during Chinese hamster ovary (CHO) cell culture. However, the redox activity and pro‐oxidant behavior of iron may also contribute toward the production of reactive oxygen species (ROS). In this work, we aim to clarify the influence of trace iron by examining the relationship between iron supplementation to culture media, mAb productivity and glycosylation, and oxidative stress interplay within the cell. Specifically, we assessed the impacts of iron supplementation on (a) mAb production and glycosylation; (b) mitochondria‐generated free hydroxyl radicals (ROS); (c) the cells ability to store energy during oxidative phosphorylation; and (d) mitochondrial iron concentration. Upon the increase of iron at inoculation, CHO cells maintained a capacity to rebound from iron‐induced viability lapses during exponential growth phase and improved mAb productivity and increased mAb galactosylation. Fluorescent labeling of the mitochondrial hydroxyl radical showed enhanced environments of oxidative stress upon iron supplementation. Additional labeling of active mitochondria indicated that, despite the enhanced production of ROS in the mitochondria, mitochondrial membrane potential was minimally impacted. By replicating iron treatments during seed train passaging, the CHO cells were observed to adapt to the shock of iron supplementation prior to inoculation. Results from these experiments demonstrate that CHO cells have the capacity to adapt to enhanced environments of oxidative stress and improve mAb productivity and mAb galactosylation with minimal perturbations to cell culture.
Randomized study of remote telehealth genetic services versus usual care in oncology practices without genetic counselors
Authors: Cacioppo Cara N. , Egleston Brian L. , Fetzer Dominique , Burke Sands Colleen , Raza Syeda A. , Reddy Malleda Neeraja , McCarty Wood Elisabeth , Rittenburg India , Childs Julianne , Cho David , Hosford Martha , Khair Tina , Khatri Jamil , Komarnicky Lydia , Poretta Trina , Rahman Fahd , Shah Satish , Patrick‐Miller Linda J. , Domchek Susan M. , Bradbury Angela R. 
Published: June 2021

AbstractPurposeTo examine the benefit of telehealth over current delivery options in oncology practices without genetic counselors.MethodsParticipants meeting cancer genetic testing guidelines were recruited to this multi‐center, randomized trial comparing uptake of genetic services with remote services (telephone or videoconference) to usual care in six predominantly community practices without genetic counselors. The primary outcome was the composite uptake of genetic counseling or testing. Secondary outcomes compare telephone versus videoconference services.Results147 participants enrolled and 119 were randomized. Eighty percent of participants in the telehealth arm had genetic services as compared to 16% in the usual care arm (OR 30.52, p < 0.001). Five genetic mutation carriers (6.7%) were identified in the telehealth arm, compared to none in the usual care arm. In secondary analyses, factors associated with uptake were lower anxiety (6.77 vs. 8.07, p = 0.04) and lower depression (3.38 vs. 5.06, p = 0.04) among those who had genetic services. There were no significant differences in change in cognitive or affective outcomes immediately post‐counseling and at 6 and 12 months between telephone and videoconference arms.ConclusionTelehealth increases uptake of genetic counseling and testing at oncology practices without genetic counselors and could significantly improve identification of genetic carriers and cancer prevention outcomes.
Regional and racial disparity in proximal gastric cancer survival outcomes 1996–2016: Results from SEER and China National Cancer Center database
Authors: Zhao Lulu , Niu Penghui , Zhao Dongbing , Chen Yingtai 
Published: June 2021

AbstractBackgroundGiven the growing incidence and aggressive biological behavior of proximal gastric cancer (PGC) as reported, it is important to understand which regional or racial populations are at poor prognosis so that interventions can be treated appropriately. We sought to explore regional treatment differences as well as racial genes influence survival outcomes in China and the US patients with PGC.MethodsPGC patients defined as tumors with the epicenter located in cardia (C16.0) or fundus (C16.1) from 1996 to 2016 were identified from the Surveillance Epidemiology and End Results (SEER) in the United States as well as data from a high‐volume National Cancer Center Database in China. Overall survival (OS) curves were plotted for different regional or racial groups, respectively, using the Kaplan‐Meier method and compared statistically using the log‐rank test. Differentially expressed genes (DEGs) analysis was performed using TCGA database.ResultsFinally, the cohort consistent of 40973 PGC patients who enrolled in SEER database (n = 36305) or China National Cancer Center (n = 4668), and divided into 4 racial groups: Chinese (n = 5179), Black (n = 2429), White (n = 31185), and Others (n = 2096). After controlling for confounding variables, racial factors were independently associated with poor survival included Black ethnicity (HR = 1.376, 95% CI: 1.066–1.7760, p = 0.014) and White ethnicity (HR = 1.262, 95% CI: 1.005–1.583, p = 0.045) when compared to Chinese ethnicity in total PGC patients. Even in the same region for only US group, Chinese PGC patients also showed better prognosis.ConclusionsIn conclusion, we demonstrated the different survival outcomes of PGC patients in different regions or races from two high‐volume database SEER and China National Cancer Center database. These survival differences are likely influenced by a number of factors (e.g., access to screening, quality of gastrectomy, neo/adjuvant therapy, and biological genes itself). More importantly, a better understanding of these disparities could lead to interventions that may help to abolish these disparities.