bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hutchinson-Gilford Progeria Syndrome (Hgps) and Application of Gene Therapy Based Crispr/Cas Technology as A Promising Innovative Treatment Approach
Authors: Rajeev Mekha , Ratan Chameli , Krishnan Karthik , Vijayan Meenu 
Published: October 2021

Background:
Hutchinson-Gilford progeria syndrome (HGPS), also known as
progeria of childhood or progeria is a rare, rapid, autosomal dominant genetic disorder
characterized by premature aging which occurs shortly after birth. HGPS occurs as a result
of de novo point mutation in the gene recognized as LMNA gene that encodes two
proteins, Lamin A protein and Lamin C protein which are the structural components of
the nuclear envelope. Mutations in the gene trigger abnormal splicing and induce internal
deletion of 50 amino acids leading to the development of a truncated form of Lamin A
protein known as Progerin. Progerin generation can be considered the crucial step in
HGPS since the protein is highly toxic to human cells, permanently farnesylated, and exhibits
variation in several biochemical and structural properties within the individual.
HGPS also produces complications such as skin alterations, growth failure, atherosclerosis,
hair and fat loss, and bone and joint diseases. We have also revised all relevant patents
relating to Hutchinson-Gilford progeria syndrome and its therapy in the current article.

Methods:
The goal of the present review article is to provide information about Hutchinson-
Gilford progeria syndrome (HGPS) and the use of CRISPR/Cas technology as a
promising treatment approach in the treatment of the disease. The review also discusses
about different pharmacological and non-pharmacological methods of treatment currently
used for HGPS.

Results :
The main limitation associated with progeria is the lack of a definitive cure. The
existing treatment modality provides only symptomatic relief. Therefore, it is high time
to develop a therapeutic method that hastens premature aging in such patients.

Conclusion:
CRISPR/Cas technology is a novel gene-editing tool that allows genome
editing at specific loci and is found to be a promising therapeutic approach for the treatment
of genetic disorders such as HGPS where dominant-negative mutations take place.
Knowledge Landscape of Starter Cultures: A Bibliometric and Patentometric Study
Authors: Cruz-O'Byrne Rosmery , Casallas-Useche Cristian , Piraneque-Gambasica Nelson , Aguirre-Forero Sonia 
Published: October 2021

Background:
Starter cultures are essential in food industry biotechnology, consisting
of microorganism preparations inoculated to produce safe fermented foods with
desirable sensory characteristics.

Objective:
This study aims to identify and analyze the growth and flow of knowledge regarding
starter cultures by creating scientific and technological profiles using patentometric
and bibliometric indicators.

Methods:
A search for patents and scientific articles was conducted in December 2020
following a proposed 10-step methodology using the Scopus® and Patentinspiration
databases. The search strategy was based on the keywords “starter culture” and “fermentation”
considering publications up to 2020.

Results:
A total of 3035 articles and 719 patents were published until 2020, presenting a
more significant number in the last ten (10) years due to the development of biological
sciences and molecular biology involving enzymes and microorganisms. Italy leads the
scientific production while China leads the technological. It was also possible to determine
the most productive author and inventors, the most influential articles and inventions,
and the main scientific journals and patent offices.

Conclusion:
Scientific and technological activities have an exponential behavior showing
that the knowledge about starter cultures continues to grow, becoming a field of interest
for optimizing industrial processes related to food fermentation, thus achieving diversification
of products that can satisfy the demand for food in an increasingly competitive
global market.
The Effect of Cardiovascular Comorbidities on Women Compared to Men: Longitudinal Retrospective Analysis
Authors: Dervic Elma , Deischinger Carola , Haug Nils , Leutner Michael , Kautzky-Willer Alexandra , Klimek Peter 
Published: October 2021

Background
Although men are more prone to developing cardiovascular disease (CVD) than women, risk factors for CVD, such as nicotine abuse and diabetes mellitus, have been shown to be more detrimental in women than in men.

Objective
We developed a method to systematically investigate population-wide electronic health records for all possible associations between risk factors for CVD and other diagnoses. The developed structured approach allows an exploratory and comprehensive screening of all possible comorbidities of CVD, which are more connected to CVD in either men or women.

Methods
Based on a population-wide medical claims dataset comprising 44 million records of inpatient stays in Austria from 2003 to 2014, we determined comorbidities of acute myocardial infarction (AMI; International Classification of Diseases, Tenth Revision [ICD-10] code I21) and chronic ischemic heart disease (CHD; ICD-10 code I25) with a significantly different prevalence in men and women. We introduced a measure of sex difference as a measure of differences in logarithmic odds ratios (ORs) between male and female patients in units of pooled standard errors.

Results
Except for lipid metabolism disorders (OR for females [ORf]=6.68, 95% confidence interval [CI]=6.57-6.79, OR for males [ORm]=8.31, 95% CI=8.21-8.41), all identified comorbidities were more likely to be associated with AMI and CHD in females than in males: nicotine dependence (ORf=6.16, 95% CI=5.96-6.36, ORm=4.43, 95% CI=4.35-4.5), diabetes mellitus (ORf=3.52, 95% CI=3.45-3.59, ORm=3.13, 95% CI=3.07-3.19), obesity (ORf=3.64, 95% CI=3.56-3.72, ORm=3.33, 95% CI=3.27-3.39), renal disorders (ORf=4.27, 95% CI=4.11-4.44, ORm=3.74, 95% CI=3.67-3.81), asthma (ORf=2.09, 95% CI=1.96-2.23, ORm=1.59, 95% CI=1.5-1.68), and COPD (ORf=2.09, 95% CI 1.96-2.23, ORm=1.59, 95% CI 1.5-1.68). Similar results could be observed for AMI.

Conclusions
Although AMI and CHD are more prevalent in men, women appear to be more affected by certain comorbidities of AMI and CHD in their risk for developing CVD.
The Challenges in Implementation of Halal Vaccine Certification in Malaysia
Authors: Latiff Johari Ab , Zakaria Zalina , Man Sa'adan 
Published: October 2021

The global halal pharmaceutical sector is valued at USD 132 billion by 2021. (Pharmaceuticals, 2020). This sector is seen as a high priority development area. Apart from food products, Muslim consumers are also becoming more aware of halal pharmaceuticals. They are beginning to see the potential detrimental effects created by product development, testing, and production, all of which could be deviating from the halal values. Based on this uncertainty, the public at large is increasingly questioning the sources of their pharmaceutical products. Under such circumstances, the situation of children contracting contagious diseases has been noted to be on the rise in Malaysia, especially in the last few years. As a result, health authorities are concerned that there would be parents who may reject the immunization programs for their children out of the fear that the vaccines used may infringe on some strict religious rules. (Johari Ab Latiff, 2018) A conservative Muslim may sometimes reject the inoculation over concerns that some vaccines were derived from contents of pigs or porcine, of which Muslims are forbidden to consume. Vaccines are part of the pharmaceutical products, and like all other pharmaceutical products, they can be developed using halal ingredients, which can replace the use of non halal contents or animal products and their derivatives for medication. The implementation of halal certification for vaccines is strictly bounded by Shariah law and Fatwa. Malaysia. As a Muslim country, Malaysia is widely and globally regarded as one of the pioneers in halal pharmaceuticals. This can be traced to its world first halal pharmaceutical standard which was introduced as MS 2424: Halal Pharmaceuticals – General Guidelines since 2012, with first revision in 2019. Nonetheless, from then until presently, Malaysia has not been able to provide halal certification for the vaccine products. The implementation of the halal certification for vaccine products in Malaysia may have been triggered by the use of non-halal or forbidden ingredients in the manufacturing of those vaccine products. Thus far, the Malaysian Standard of the MS 2424 is the only standard, and it is also only a general guide. There is a need to develop a more thorough manual that can be adhered to by pharmaceuticals. This necessity to certify vaccine products as halal for the context of Malaysia has thus put the Halal Certification Body, like JAKIM, to be in limbo
Stability Test of Gel Hand Sanitizer Ethanol Extract of Nutmeg (Pala) Leaves (Myristica fragrans Houtt.) with Variation of the Concentration of HPMC (Hydroxy Propyl Methyl Cellulose) and Glycerine
Authors: Nur Endah Srie Rezeki , Shintia C , Nofriyaldi A 
Published: October 2021

Daun pala (Myristica fragrans Houtt.) memiliki senyawa metabolit sekunder seperti flavonoid, saponin dan tanin. Oleh karena itu, daun pala dikembangkan ke dalam bentuk sediaan gel hand sanitizer yang berpotensi sebagai antibakteri. Dalam formulasi gel, penggunaan gelling agent dan humektan merupakan faktor penting yang dapat menghasilkan sediaan gel yang stabil. Tujuan dari penelitian ini yaitu untuk mengetahui stabilitas sediaan gel hand sanitizer ekstrak etanol daun pala dengan variasi konsentrasi HPMC dan gliserin. Gel hand sanitizer ini dibuat 3 formulasi dengan variasi HPMC dan gliserin, yaitu formula 1 (HPMC 1% : gliserin 5%), formula 2 (HPMC 1.5% : gliserin 7.5%), formula 3 (HPMC 2%, gliserin 10%). Uji stabilitas yang dilakukan terhadap sediaan menggunakan metode cycling test sebanyak 6 siklus. Berdasarkan hasil analisis cycling test 6 siklus dihasilkan bahwa formula yang memiliki stabilitas paling baik adalah formula 1 dengan variasi konsentrasi HPMC 1% dan gliserin 5%.
The Preparation and Characterization of A Co-Processed Excipient from Purple Sweet Potato (Ipomoea batatas L) Starch and Avicel PH101
Authors: Muhammad Hengki Purnama Halim  , Eka Purwanto Ungsari Rizki , Ikasari Endang Diyah 
Published: October 2021

The Indonesian pharmaceutical industries still rely on imports for more 90% of active raw materials and excipient raw materials. A research is needed to develop the production of pharmaceutical excipients, especially those derived from natural ingredients, to support the country's economy. One source of natural materials are widely available in Indonesia and can be developed is starch from Purple Sweet Potato (Ipomoea batatas L). Starch is often used as dilluent, disintegrat and binder in tablet formulation.
Starch, including starch from Purple Sweet Potato, was an excipient tablet that had bad flowability and compressibility, so that the physical properties need to be improved. One way to improve the characterization of amilum is co-processing. The purpose of this study was to develop a co-process from Purple Sweet Potato Starch and combined with Avicel PH 101 as excipient fillers for tablets.
The method used in the preparation of these co-process was wet granulation. The formula determination was caried out with Design Expert 10.0.1 software. Results obtained from experiments and recommendation formula from Design Expert 10.0.1 was verified with One Simple T-test with confidence level of 95%.
Based on the results it can be concluded that the increased concentration of purple sweet potato starch increased moisture content and lowering compressibility and density. While the increased concentration of Avicel PH 101 increased compressibility and density; it could lower moisture content and the flowability time. The formula that gave the best characteristic of co-processed was obtained at a concentration of purple sweet potato starch and Avicel PH 101 on 62.493%: 37.507%. Based on One Simple T-Test, there is no significant difference between the experimental results with recommendation formula from Design Expert 10.0.1. From the FT-IR test results may indicate that the formation of the co-process did not change the form of the chemical structure of substances, but only changed the physical properties of substance. Based on the results of SEM, the morphology of the shape bond formation co-process so that the granules become larger and purple sweet potato starch forms a round and partly change shape after do the heating at 60°C.
Keyword : Co-processing, Purple_Sweet_Potato, Starch, Avicel_PH101, FTIR
The Role of Service Promotional Mix on Customer Satisfaction; Case Study of Agriculture and Rural Development Bank in Djelfa
Authors: Gourida Siham 
Published: October 2021

Now days, the issues of promotional efforts of banking services are becoming more complicated, in today’s competitive environment, in terms of competing effectively with other financial institutions. In banking sector communication elements are especially important, they help to create powerful images, confidence and a sense of reliability to achieve customers’ satisfaction.The main purpose of this study is to reach a better understanding of the promotion’s strategies in financial institutions. In order to reach this target we’ve conducted a questionnaire for clients of our case study bank, to examine the role that the promotion mix components play in terms of reaching the bank customers’ satisfaction. The results show that the personal selling plays an important role on achieving customer satisfaction.
Never Again: A Legal Chimarea?
Authors: Hale Christopher John 
Published: October 2021

This article examines the scope of the duty that arises from Article 1 of the Genocide Convention[1] (hereinafter, the Convention) that imposes on States the dual obligation to prevent and punish genocide as an international crime. The analysis will focus on the legal problems arising from the punishable acts of Article 3 which asserts a prophylactic framework regarding the crime of genocide. This article argues that Article 3 is fundamental to the obligation to prevent as well as punish since the prohibited acts are inchoate (meaning incomplete). If an act of genocide is legally conceived as incomplete, it can, in theory, be repressed in the spirit of the Convention.

[1] “Convention on the Prevention and Punishment of the Crime of Genocide,” open for signature December 9, 1948, registration no. A/RES/3/260, http://un-documents.net/a3r260.htm.
The dynamics of recovery processes of physical activity of people who recovered from COVID-19
Authors: Kokhan Sergey , Romanova Elena , Dychko Vladislav , Dychko Elena , Dychko Danil , Shayda Oleksandr 
Published: October 2021

The article shows the results of physical therapy of those who have had coronavirus infection COVID-19 and who have completed a month's course of physical rehabilitation as a part of rehabilitation measures in the conditions of the innovative clinic "Academy of Health". The aim of the research is to study the impact of pulmonary rehabilitation programs for patients with moderate to severe COVID-19. The implementation of special breathing exercises made it possible to improve the oxygen saturation in the blood, to reduce shortness of breath and indicators of respiratory symptoms. The tolerance to exercise has increased; physical activity and the quality of life of patients with pneumonia associated with COVID-19 have improved. The best results of the EQ-5D quality of life assessment were recorded in the experimental group compared to the control group.
PERBANDINGAN SERVICE QUALITY MUSEUM KRETEK DENGAN MUSEUM JENANG KUDUS
Authors: Hanif Asyharudin , Lucky Alfa Saputra Ihfadz Lucky Alfa Saputra , Putri Mardiana Dewi Putri Mardiana , Primadasa Rangga 
Published: October 2021

In Kudus district, has two museums which Museum Kretek and Museum Jenang Kudus. In 2018 the number of visitors to the Museum Kretek reached 102,998 visitors, while the total visitors to the Musuem Jenang Kudus reached 397,625. The difference reaching 294,627 raises the question of how the service quality between the two museums. This study used the SERVQUAL Model method to determine the service quality of the two Musuem as well as a comparison of the service quality of the Museum Kretek and the Museum Jenang Kudus. The results of the study revealed that of the 100 reapondents who had visited the Museum Kretek and the Museum Jenang Kudus, the Museum Jenang Kudus had a better perception of service quality according to respondents. Based on the results of this study, we suggest that both museums improve service quality, especially in service quality items that get a low perception of respondents
UPAYA ASĀTĪDZ DALAM MENINGKATKAN KEMAMPUAN MEMBACA KITAB KUNING AL-YAQŪT AL-NAFĪS DI MADRASAH ALIYAH
Authors: Akhiryani Atna , Titin Fatimah  , ASLAN F LATINGARA  
Published: October 2021

This research aims at finding out the teachers’ effort in developing the students’ ability in reading Al-Yaqūt Al-Nafīs at class two senior high school. This research employed the Descriptive Qualitative method. Its findings indicate an increase in the teachers’ effort in developing students’ ability in reading and translating Al-Yaqūt Al-Nafīs. The teachers applied sorogan method in the teaching and learning process and applied repetition and practice techniques in learning Al-Yaqūt Al-Nafīs.
Manjemen Kepemimpinan Kepala Sekolah Dalam Peningkatan Kinerja Guru di Madrasah Ibtidaiyah Mujahidin Loloan Barat
Authors: Imam Turmudi Imam Turmudi 
Published: October 2021

Dalam menjalankan organisasi sekolah, seorang pemimpin harus mampu mengemudikan dan menjalankan organisasinya. Artinya seorang pemimpin harus mampu membawa perubahan, karena perubahan adalah tujuan pokok dari kepemimpinan.
tujuan penelitian di antaranya untuk mendeskripsikan gaya kepemimpinan kepala sekolah di Madrasah Ibtidaiyah Mujahidin Loloan Barat. Penelitian ini menggunakan pendekatan kualitatif dengan jenis deskriptif. Teknis pengumpulan data menggunakan tiga cara yaitu observasi, wawancara dan dokumentasi. Data yang terkumpul kemudian dianalisis dengan mengikuti prosedur Reduksi data, Display data, dan kesimpulan
Hasil dari penelitian ini disimpulkan bahwa: Pertama, Gaya kepemimpinan kepala sekolah di Madrasah Ibtidaiyah Mujahidin Loloan Barat lebih dominan menggunakan gaya kepemimpinan demokratis dan dalam pengambilan keputusan yang mendesak, gaya kepemimpinan yang digunakan adalah gaya kepemimpinan otokrasi atau otoriter. Kedua, Kinerja guru di Madrasah Ibtidaiyah Mujahidin Loloan Barat dapat dikatakan sangat baik dan tingkat tinggi karena dengan melihat kompetensi guru yang meliputi kompetensi paedagodik, kompetensi kepribadian, kompetensi sosial, dan kompetensi profesional. Ketiga, Manajemen kepemimpinan kepala sekolah dalam peningkatan kinerja guru di Madrasah Ibtidaiyah Mujahidin Loloan Barat dapat dikatakan sangat baik dengan menggunakan gaya kepemimpinan demokratis dan otoriter serta supervisi observasi kelas dalam kegiatan-kegiatan, yaitu kegiatan harian, mingguan, bulanan, dan semester.
Paleospecies as cognitive construct: The meme of “Homo floresiensis”
Authors: Eckhardt Robert B. , Henneberg Maciej 
Published: October 2021

Creation and subsequent abandonment of a number of earlier species considered human ancestors: Eoanthropus dawsoni, Hesperopithecus haroldcooki, Homo gardarensis and Ramapithecus punjabicus is presented using cases from the history of science. This review indicates that the fossil evidence for these species has been questionable from the beginning but that mental images – memes – they invoked were attractive to students of human evolution and as such persisted even if not confirmed by further finds, with new research still being disputed. Against this background the status of the recent construction of the hominin species “Homo floresiensis” is discussed showing that despite dubious interpretations of the objective data and a relatively long time of non-confirmation due to paucity of newly discovered skeletal remains, the “species” still exists in minds of scholars and in the scientific literature extending into textbooks.
Sex differences in younger school age children’s body weight categories
Authors: Zbořilová Vendula , Přidalová Miroslava , Sigmundová Dagmar 
Published: October 2021

The issue of inadequate or excessive children’s body weight, particularly in relation to their health, is also discussed by Czech experts in physical anthropology, auxology, paediatrics, endocrinology, etc. Overweight and obesity occur already at a younger school age, and some domestic and foreign sources report a higher prevalence in boys.
The objective of this study was to describe distribution range in body weight categories among Czech children of younger school age (6 to 11 years) taking into account age and sex.
Our research was carried out at 23 primary schools in 5 regions of the Czech Republic between 2014 and 2018. The research group consisted of 2,099 children aged 6 to 11 years (boys n = 1,015, 48.4%; girls n = 1,084, 51.6%). Probands were subjected to the standard anthropometric examination with body weight being assessed using the following assessment standards: the Czech national growth references, Nationwide Anthropological Survey of Czech Children and Adolescents (NAS), World Health Organisation (WHO) growth standards, and International Obesity Task Force (IOTF) references were used. Statistical tests were carried out at a significance level of p ≤ 0.05; residual analysis.
According to all three assessment standards, the highest prevalence of children with normal body weight was in both sexes; 45.8% of girls and 48.4% of boys, using the Czech assessment reference. Overweight and obesity were more predominant in boys (7.9% and 8.7%) than in girls (7.7% and 7.5%). One point seven percent of boys and girls were equally underweight, whereas the percentage of girls (22.3%) with reduced body weight was higher than in boys (20.3%). A significant difference between boys and girls was found in the category of reduced body weight in nine-year-old children. Using internationally recommended BMI references, more children fell into the category of normal body weight. Significant differences, in accordance with IOTF, between the number of severely underweight boys and girls were observed in 7-year-olds, slightly underweight in 9- and 11-year-olds, and overweight in 7-year-olds. In accordance with the WHO growth standards, significant differences appeared between eight-year-olds and eleven-year-olds obese boys and girls.
Our research study revealed the prevalence in younger school age children body weight categories. Different BMI references were used to classify body weight. Significant differences between the number of boys and girls were observed in certain weight categories in seven-year-old, eight-year-old, nine-year-old and eleven-year-old children. Thus, the study confirmed the presence of differences in the number of boys and girls in specific body weight categories.