bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ectopic gas in the fibular graft after anterior cervical corpectomy and fusion
Authors: Nozawa Satoshi , Kato Hiroki , Kawaguchi Masaya , Nozawa Asae , Yamada Kazunari , Iwai Chizuo , Fushimi Kazunari , Miyamoto Kei , Hosoe Hideo , Shimizu Katsuji , Matsuo Masayuki , Akiyama Haruhiko 
Published: November 2021

Abstract
Background
Ectopic gas in the graft is occasionally encountered upon follow-up computed tomography (CT) after anterior cervical corpectomy and fusion (ACCF). However, most cases lack inflammatory responses and manifestations of infection. Although the clinical significance of ectopic gas in the graft has not yet been established, to the best of our knowledge, no previous studies have described ectopic gas in the graft after ACCF. This study evaluated ectopic gas in the fibular graft upon follow-up CT after ACCF.

Methods
We reviewed 112 patients who underwent ACCF and follow-up CT, with a minimum follow-up period of 3 years. CT images were retrospectively reviewed to confirm the presence of ectopic gas in the graft and bone fusion. Bone fusion was defined as follows: mobility less than 2 mm between spinous processes on the flection-extension radiograph or a bone bridge on CT images.

Results
Of the 112 patients, 30 (27%) patients had ectopic gas in the fibular grafts. Among them, ectopic gas was initially observed 3 months after surgery (early onset) in 23 (77%) patients and 6 months after surgery (late-onset) in the remaining seven (23%) patients. Upon the latest follow-up CT, ectopic gas more frequently remained in late-onset (4/7, 57%) rather than in early-onset (3/23, 13%) cases (p = 0.033). Bone fusion was not observed when CT images exhibited ectopic gas in the graft, whereas ectopic gas was not observed when CT images exhibited bone fusion.

Conclusion
Ectopic gas in the fibular graft was observed at both early and late-onset after ACCF; late-onset gas remained significantly. The remaining gas was strongly associated with pseudoarthrosis; therefore, pseudoarthrosis should be considered when ectopic gas in the graft is observed on CT images.
Hurdles for adopting mobile learning devices at the outset of clinical courses
Authors: Folger Daniel , Merenmies Jussi , Sjöberg Lena , Pyörälä Eeva 
Published: November 2021

Abstract
Background
Mobile devices provide medical students with easy access to medical information and educational resources. Since 2013, we have followed the study use of iPads among medical students. In 2016, we observed a notable drop in the mobile device usage in the first cohort of medical students entering their clinical courses.

Methods
The aim of the study was to identify the hurdles for adopting mobile devices at the beginning of the clinical courses. We examined how students evaluated their own and the clinical teachers’ ability to use the iPad, how the study assignments fit into digital learning, and how students used the mobile device with patients. The data were collected with online surveys among three consecutive student cohorts and the distributions of closed-ended questions analyzed.

Results
Response rates ranged from 67.5 to 90.8%. Students evaluated their own ability to use the iPad as good or excellent and teachers’ skills as relatively poor and wanted more digitally tailored assignments. They reported negative attitudes towards mobile device use in the clinical setting and were hesitant to use them in patient contact. Teachers seldom communicated suitable quality medical applications to students.

Conclusions
Clinical teachers need support and training to implement a learning environment and assignments appropriate for mobile devices. Both students and teachers were concerned about using these devices with patients. To achieve the full potential of digitalisation in clinical courses, their use should be developed collectively with students.
Circular RNA circVAPA contributes to non-small-cell lung cancer progression via miR-342-3p-dependent regulation of ZEB2
Authors: Liu Xiaoyang , Cheng Yang , Wang Yan , Zhang Yinhong 
Published: November 2021

Abstract
Background
Accumulating evidence demonstrated that circular RNAs (circRNAs) play pivotal regulatory roles in the pathology of cancers. Disclosing the roles and molecular mechanisms of circRNAs in tumorigenesis and development is essential to identify novel diagnostic and therapeutic targets. In this study, we explored the role of circVAPA in non-small-cell lung cancer (NSCLC) progression and its associated mechanism.

Methods
The expression level of RNA was analyzed by real-time quantitative polymerase chain reaction (RT-qPCR). Cell proliferation was assessed by MTT assay and colony-forming assay. Cell apoptosis was analyzed by flow cytometry. Cell migration and invasion were assessed by transwell assays. Dual-luciferase reporter, RNA pull-down, and RNA immunoprecipitation (RIP) assays were used to test the intermolecular interactions. The role of circVAPA was assessed in vivo. And xenograft tumor tissues were analyzed by immunohistochemistry (IHC) staining.

Results
CircVAPA expression was upregulated in NSCLC tissues and cell lines, and a high level of circVAPA was associated with a poor prognosis of NSCLC patients. CircVAPA silencing suppressed the proliferation, migration, and invasion and induced the apoptosis of NSCLC cells. CircVAPA served as a molecular sponge for microRNA-342-3p (miR-342-3p). miR-342-3p interference largely reversed circVAPA knockdown-mediated anti-tumor effects in NSCLC cells. Zinc finger E-box-binding homeobox 2 (ZEB2) was a target of miR-342-3p, and miR-342-3p overexpression suppressed the malignant behaviors of NSCLC cells largely by downregulating ZEB2. CircVAPA silence repressed xenograft tumor growth in vivo, and IHC assay confirmed that circVAPA silence restrained the proliferation and metastasis but induced the apoptosis of NSCLC cells in vivo.

Conclusion
CircVAPA contributes to the progression of NSCLC by binding to miR-342-3p to upregulate ZEB2. CircVAPA/miR-342-3p/ZEB2 axis might be a novel potential target for NSCLC treatment.
Tonicity-responsive enhancer-binding protein promotes diabetic neuroinflammation and cognitive impairment via upregulation of lipocalin-2
Authors: Jeong Eun Ae , Lee Jaewoong , Shin Hyun Joo , Lee Jong Youl , Kim Kyung Eun , An Hyeong Seok , Kim Deok Ryong , Choi Kyu Yeong , Lee Kun Ho , Roh Gu Seob 
Published: November 2021

Abstract
Background
Diabetic individuals have increased circulating inflammatory mediators which are implicated as underlying causes of neuroinflammation and memory deficits. Tonicity-responsive enhancer-binding protein (TonEBP) promotes diabetic neuroinflammation. However, the precise role of TonEBP in the diabetic brain is not fully understood.

Methods
We employed a high-fat diet (HFD)-only fed mice or HFD/streptozotocin (STZ)-treated mice in our diabetic mouse models. Circulating TonEBP and lipocalin-2 (LCN2) levels were measured in type 2 diabetic subjects. TonEBP haploinsufficient mice were used to investigate the role of TonEBP in HFD/STZ-induced diabetic mice. In addition, RAW 264.7 macrophages were given a lipopolysaccharide (LPS)/high glucose (HG) treatment. Using a siRNA, we examined the effects of TonEBP knockdown on RAW264 cell’ medium/HG-treated mouse hippocampal HT22 cells.

Results
Circulating TonEBP and LCN2 levels were higher in experimental diabetic mice or type 2 diabetic patients with cognitive impairment. TonEBP haploinsufficiency ameliorated the diabetic phenotypes including adipose tissue macrophage infiltrations, neuroinflammation, blood–brain barrier leakage, and memory deficits. Systemic and hippocampal LCN2 proteins were reduced in diabetic mice by TonEBP haploinsufficiency. TonEBP (+ / −) mice had a reduction of hippocampal heme oxygenase-1 (HO-1) expression compared to diabetic wild-type mice. In particular, we found that TonEBP bound to the LCN2 promoter in the diabetic hippocampus, and this binding was abolished by TonEBP haploinsufficiency. Furthermore, TonEBP knockdown attenuated LCN2 expression in lipopolysaccharide/high glucose-treated mouse hippocampal HT22 cells.

Conclusions
These findings indicate that TonEBP may promote neuroinflammation and cognitive impairment via upregulation of LCN2 in diabetic mice.
Gaussian noise up-sampling is better suited than SMOTE and ADASYN for clinical decision making
Authors: Beinecke Jacqueline , Heider Dominik 
Published: November 2021

AbstractClinical data sets have very special properties and suffer from many caveats in machine learning. They typically show a high-class imbalance, have a small number of samples and a large number of parameters, and have missing values. While feature selection approaches and imputation techniques address the former problems, the class imbalance is typically addressed using augmentation techniques. However, these techniques have been developed for big data analytics, and their suitability for clinical data sets is unclear.This study analyzed different augmentation techniques for use in clinical data sets and subsequent employment of machine learning-based classification. It turns out that Gaussian Noise Up-Sampling (GNUS) is not always but generally, is as good as SMOTE and ADASYN and even outperform those on some datasets. However, it has also been shown that augmentation does not improve classification at all in some cases.
Evidence for foot orthoses for adults with flatfoot: a systematic review
Authors: Herchenröder Minettchen , Wilfling Denise , Steinhäuser Jost 
Published: November 2021

AbstractBackgroundFlatfoot is characterised by the falling of the medial longitudinal arch, eversion of the hindfoot and abduction of the loaded forefoot. Furthermore, flatfoot leads to a variety of musculoskeletal symptoms in the lower extremity, such as knee or hip pain. The standard conservative treatment for flatfoot deformity is exercise therapy or treatment with foot orthoses. Foot orthoses are prescribed for various foot complaints. However, the evidence for the provision of foot orthoses is inconsistent. The aim of this systematic review is to synthesize the evidence of foot orthoses for adults with flatfoot.MethodsA computerized search was conducted in August 2021, using the databases PubMed, Scopus, Pedro, Cochrane Library, and the Cochrane Central Register of Controlled Trials. Intervention studies of any design investigating the effects of foot orthoses were included, apart from case studies. Two independent reviewers assessed all search results to identify eligible studies and to assess their methodological quality.ResultsA total of 110 studies were identified through the database search. 12 studies met the inclusion criteria and were included in the review. These studies investigated prefabricated and custom‐made foot orthoses, evaluating stance and plantar pressure during gait. The sample sizes of the identified studies ranged from 8 to 80. In most of the studies, the methodological quality was low and a lack of information was frequently detected.ConclusionThere is a lack of evidence on the effect of foot orthoses for flatfoot in adults. This review illustrates the importance of conducting randomized controlled trials and the comprehensive development of guidelines for the prescription of foot orthoses. Given the weak evidence available, the common prescription of foot orthoses is somewhat surprising.
Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support
Authors: Rilinger Jonathan , Krötzsch Klara , Bemtgen Xavier , Jäckel Markus , Zotzmann Viviane , Lang Corinna N. , Kaier Klaus , Duerschmied Daniel , Supady Alexander , Bode Christoph , Staudacher Dawid L. , Wengenmayer Tobias 
Published: November 2021

Abstract
Background
There is limited information about the long-term outcome of patients suffering from acute respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (VV ECMO). Most studies focused on short- to mid-term follow-up. We aimed to investigate long-term survival and health-related quality of life (HRQL) in these patients.

Methods
We report retrospective data from a single-centre registry of patients with severe ARDS treated with VV ECMO at the Interdisciplinary Medical Intensive Care Unit at the Medical Centre, University of Freiburg, Germany, between 10/2010 and 06/2019. Follow-up data of all patients that survived the index hospitalisation were collected by telephone interviews from 02/2020 till 09/2020. Long-term survival, HRQL (Short-Form Health Survey-36 (SF-36), St. Georges Respiratory Questionnaire (SGRQ), Hospital Anxiety and Depression Scale (HADS)) and the return to work rate were documented.

Results
In total, 289 patients were treated with VV ECMO during the study period (median age 55 years, 67% males, hospital survival 45%). After a median duration of 3.9 years, follow-up assessment was complete in 94 of 129 hospital survivors (73%). Fifty-three patients completed the HRQL assessment. Hospital survivors showed a high 6- and 12-month survival rate (89% and 85%, respectively). Estimated survival rate of those discharged alive from ICU was 68.5% (95%-CI 56.9–80.1%) after 9.7 years. These patients reported high levels of HRQL (median SF-36 total score 73) and only few pulmonary (median SGRQ total score 19) and mental limitations (median HAD-D score 2 and HAD-A score 3). In total, 80% of the patients were able to resume employment.

Conclusion
This analysis of VV ECMO patients showed favourable long-term survival and high levels of HRQL suggesting promising prospects for VV ECMO survivors.

Graphical Abstract
A new formulation of finite difference and finite volume methods for solving a space fractional convection–diffusion model with fewer error estimates
Authors: Edwan Reem , Al-Omari Shrideh , Al-Smadi Mohammed , Momani Shaher , Fulga Andreea 
Published: November 2021

AbstractConvection and diffusion are two harmonious physical processes that transfer particles and physical quantities. This paper deals with a new aspect of solving the convection–diffusion equation in fractional order using the finite volume method and the finite difference method. In this context, we present an alternative way for estimating the space fractional derivative by utilizing the fractional Grünwald formula. The proposed methods are conditionally stable with second-order accuracy in space and first-order accuracy in time. Many comparisons are performed to display reliability and capability of the proposed methods. Furthermore, several results and conclusions are provided to indicate appropriateness of the finite volume method in solving the space fractional convection–diffusion equation compared with the finite difference method.
IDS-attention: an efficient algorithm for intrusion detection systems using attention mechanism
Authors: Laghrissi FatimaEzzahra , Douzi Samira , Douzi Khadija , Hssina Badr 
Published: November 2021

AbstractNetwork attacks are illegal activities on digital resources within an organizational network with the express intention of compromising systems. A cyber attack can be directed by individuals, communities, states or even from an anonymous source. Hackers commonly conduct network attacks to alter, damage, or steal private data. Intrusion detection systems (IDS) are the best and most effective techniques when it comes to tackle these threats. An IDS is a software application or hardware device that monitors traffic to search for malevolent activity or policy breaches. Moreover, IDSs are designed to be deployed in different environments, and they can either be host-based or network-based. A host-based intrusion detection system is installed on the client computer, while a network-based intrusion detection system is located on the network. IDSs based on deep learning have been used in the past few years and proved their effectiveness. However, these approaches produce a big false negative rate, which impacts the performance and potency of network security. In this paper, a detection model based on long short-term memory (LSTM) and Attention mechanism is proposed. Furthermore, we used four reduction algorithms, namely: Chi-Square, UMAP, Principal Components Analysis (PCA), and Mutual information. In addition, we evaluated the proposed approaches on the NSL-KDD dataset. The experimental results demonstrate that using Attention with all features and using PCA with 03 components had the best performance, reaching an accuracy of 99.09% and 98.49% for binary and multiclass classification, respectively.
Population assessment and habitat associations of the Visayan Hornbill (Penelopides panini) in Northwest Panay, Philippines
Authors: Mynott Holly Isabelle , Lee David Charles , Santillan Rhea Aranas , Schwarz Christian Jürgen , Tacud Benjamin , Fernandez Arcel Dryden , Kerhoas Daphne 
Published: November 2021

AbstractBackgroundSeven out of ten hornbill species in the Philippines are threatened with extinction. Among these is the endangered Visayan Hornbill (Penelopides panini), found on the islands of Panay and Negros. Threatened by habitat loss and hunting, its population size is thought to have declined from 1800 individuals 20 years ago to less than 1000. However, a recent study on Negros estimated 3564 individuals across three core forest blocks. This study aims to quantify the Visayan Hornbill population size in and around the Northwest Panay Peninsula Natural Park (NWPPNP) on Panay, the largest contiguous low-elevation forest landscape remaining across its range, and its broad habitat associations across a gradient of environmental degradation.MethodsHornbills were surveyed using 10-min distance sampling point counts (n = 367) along transects (average length 1.1 km). Environmental variables were recorded along transects, while habitat was classified into primary forest, secondary forest, plantation, or open habitat. Distance software was used to estimate population densities stratified by habitat, with the overall population estimate taken as a mean of habitat density estimates weighted by habitat area. Using generalized linear mixed models, hornbill occurrence was modelled using combinations of nine environmental variables as main and two-way fixed effects.ResultsSurveys covered 204.4 km2of the 374.8 km2Northwest Panay Peninsula. Hornbills were not recorded in plantations or open habitats. Hornbill density was significantly higher in primary forest (17.8 individuals/km2 ± 26.9% CV) than in secondary forest (3.7 individuals/km2 ± 33.2% CV;z = 15.212,P < 0.001). The overall population estimate for the NWPPNP and environs is 2109 individuals, and 2673 individuals for the entire Northwest Panay Peninsula. Hornbill presence was best explained by a model including distance from the Park boundary alongside five interaction effects and transect as a random effect. Distance, and the interaction between distance and medium-sized trees were significant predictors of hornbill presence.ConclusionsOur study evidences the habitat preference of the Visayan Hornbill, highlights the importance of the NWPPNP for the species’ conservation, and provides strong evidence for re-assessing the global population size.
Bio-algae: a study of an interactive facade for commercial buildings in populated cities
Authors: Hanafi Walaa Hussein Hussein 
Published: November 2021

AbstractClimate change, global energy demand, and greenhouse emissions from energy (formerly CO2 emissions from fuel combustion) have emerged as the most serious threats to humans, particularly in densely populated cities. As a result, there are calls to reconnect with nature and draw inspiration from its mechanisms as well as to use clean renewable energy resources. Thus, this paper presents a biomimicry approach—a strategy for achieving ecological balance—to biofuel using algae in a building facade, and considers a case study building in Giza city as an example of a populated city in Egypt for retrofitting its skin with a nature-inspired solution. Using mathematical calculation, energy load analysis, and interviews with interested specialists, architects, and building occupants about this technology, then compared the performance of the case study commercial building facade with the proposed algae facade for energy generate. The results indicate that electrical energy consumption can be reduced by 45 to 50%, and carbon emissions could be reduced. In addition, other benefits for the building environment and societal acceptance were revealed. The study concluded that using algae as an element of the building skin in densely populated cities as a biomimicry architecture strategy contributes to an innovative environmental approach.
More than just anti-NMDAR: the many facets of autoimmune encephalitis
Authors: Abdel Aziz Karim , Stip Emmanuel , Arnone Danilo 
Published: November 2021

SummaryThis editorial expands on a Praxis article published by Beattie and colleagues in the trainees’ section of this journal. The authors describe an interesting case of anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis, outline the clinical presentation and make suggestions on ways to approach this rare disorder. Here we provide an overview of autoimmune conditions that result in the production of autoantibodies targeting central nervous system proteins mediating autoimmune encephalitis and offer a perspective on approaches to diagnosis and treatment.
Capturing adolescents in need of psychiatric care with psychopathological symptoms: A population-based cohort study
Authors: Rotstein Anat , Goldenberg Judy , Fund Suzan , Levine Stephen Z. , Reichenberg Abraham 
Published: November 2021

AbstractBackgroundThe current study aims to overcome past methodological limitations and capture adolescents in need of psychiatric care with psychopathological symptoms in a cohort with unrestricted access to mental health professionals.MethodsThe study source population consisted of a random sample of adolescents aged 16-17 years (N=1,369) assessed by the Israeli Draft Board. An adapted version of the Brief Symptom Inventory was used to identify clinically relevant psychopathological symptoms with scores categorized as severe if they were in the top 10th percentile of symptoms, otherwise not severe. An independent interview with a subsequent referral to a mental health professional was used to categorize adolescents in need of psychiatric care. To examine the association between severe psychopathological symptoms and the need for psychiatric care, logistic regression models were fitted unadjusted and adjusted for age, sex, and intellectual assessment scores. Adjusted classification measures were estimated to examine the utility of severe psychopathological symptoms for clinical prediction of need for psychiatric care.ResultsInformation on 1,283 adolescents was available in the final analytic sample. Logistic regression modeling showed a statistically significant (p<0.001) association between self-reported severe psychopathological symptoms and the need for psychiatric care (OR adjusted: 4.38; 95% CI: 3.55–5.40). Severe psychopathological symptoms had a classification accuracy of 83% (CI: 81%–85%).ConclusionsSevere psychopathological symptoms, although accounting for a fair proportion of treatment seeking, would perhaps be better useful for classification purposes alongside other variables rather than in isolation.