bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH KUALITAS PRODUK DAN PROMOSI TERHADAP KEPUTUSAN PEMBELIAN
Authors: Aditya Galuh , Ristanto Hesti , . Catur 
Published: September 2021

Penelitian ini bertujuan untuk menganalisis pengaruh kualitas produk dan promosi terhadap keputusan pembelian produk di CV. Mitra Sejati Foamindo Semarang.
Populasi dalam penelitian ini yaitu konsumen yang melakukan pembelian produk di CV. Mitra Sejati Foamindo Semarang. Pada penelitian ini menggunakan sampel sebanyak 96 responden dipilih dengan metode purposive sampling dimana semua individu yang ada didalam populasi dimasukkan sebagai responden dengan pertimbangan tertentu. Teknik analisis yang digunakan adalah regresi linear berganda.
Berdasarkan pada hasil analisis dan pembahasan, maka dapat ditarik kesimpulan sebagai berikut : (1). Kualitas produk berpengaruh positif dan signifikan terhadap keputusan pembelian. (2). Promosi berpengaruh positif dan signifikan terhadap keputusan pembelian.
Kata Kunci : Kualitas Produk, Promosi dan Keputusan Pembelian
Keputusan Pembelian Natural Cosmetics dengan Predicator Green Awareness dan Green Brand Trust
Authors: Suroso Iwan , Hesty Ratih , Kuncoro Amin 
Published: September 2021

Abstract
Penelitian ini bertujuan untuk mengetahui pengaruh variabel green brand awareness dan green brand trust terhadap keputusan pembelian natural cosmetics product Sariayu di Kabupaten Kudus. Desain penelitian menggunakan penelitian deskriptif kuantitatif dengan menggunakan data primer. Populasi dalam penelitian ini konsumen produk Sariayu Martha Tilaar. Hasil dari pengujian yang telah dilakukan dinyatakan bahwa ada pengaruh positif dan signifikan antara variabel green brand awareness dan green brand image terhadap keputusan pembelian secara parsial. Namun secara parsial varaibel green brand trust tidak berpengaruh terhadap keputusan pembelian natural cosmetics product.
Kata kunci: Keputusan pembelian, green awareness dan green brand trust
Evaluation of Landslide Susceptibility of Şavşat District of Artvin Province (Turkey) Using Machine Learning Techniques
Authors: Akinci Halil , Zeybek Mustafa , Dogan Sedat 
Published: September 2021

The aim of this study is to produce landslide susceptibility maps of Şavşat district of Artvin Province using machine learning (ML) models and to compare the predictive performances of the models used. Tree-based ensemble learning models, including random forest (RF), gradient boosting machines (GBM), and extreme gradient boosting (XGBoost), were used in the study. A landslide inventory map consisting of 85 landslide polygons was used in the study. The inventory map comprises 32,777 landslide pixels at 30 m resolution. Randomly selected 70% of the landslide pixels were used for training the models and the remaining 30% were used for the validation of the models. In susceptibility analysis, altitude, aspect, curvature, distance to drainage network, distance to faults, distance to roads, land cover, lithology, slope, slope length, and topographic wetness index parameters were used. The validation of the models was conducted using success and prediction rate curves. The validation results showed that the success rates for the GBM, RF, and XGBoost models were 91.6%, 98.4%, and 98.6%, respectively, whereas the prediction rate were 91.4%, 97.9%, and 98.1%, respectively. Therefore, it was concluded that landslide susceptibility map produced with XGBoost model can help decision makers in reducing landslide-associated damages in the study area.
Multiple introductions of multidrug-resistant typhoid associated with acute infection and asymptomatic carriage, Kenya
Authors: Kariuki Samuel , Dyson Zoe A , Mbae Cecilia , Ngetich Ronald , Kavai Susan M , Wairimu Celestine , Anyona Stephen , Gitau Naomi , Onsare Robert Sanaya , Ongandi Beatrice , Duchene Sebastian , Ali Mohamed , Clemens John David , Holt Kathryn E , Dougan Gordon 
Published: September 2021

Background:Understanding the dynamics of infection and carriage of typhoid in endemic settings is critical to finding solutions to prevention and control.Methods:In a 3-year case-control study, we investigated typhoid among children aged <16 years (4670 febrile cases and 8549 age matched controls) living in an informal settlement, Nairobi, Kenya.Results:148 S. Typhi isolates from cases and 95 from controls (stool culture) were identified; a carriage frequency of 1 %. Whole-genome sequencing showed 97% of cases and 88% of controls were genotype 4.3.1 (Haplotype 58), with the majority of each (76% and 88%) being multidrug-resistant strains in three sublineages of the H58 genotype (East Africa 1 (EA1), EA2, and EA3), with sequences from cases and carriers intermingled.Conclusions:The high rate of multidrug-resistant H58 S. Typhi, and the close phylogenetic relationships between cases and controls, provides evidence for the role of carriers as a reservoir for the community spread of typhoid in this setting.Funding:National Institutes of Health (R01AI099525); Wellcome Trust (106158/Z/14/Z); European Commission (TyphiNET No 845681); National Institute for Health Research (NIHR); Bill and Melinda Gates Foundation (OPP1175797).
Human factor associations with safety events in radiation therapy
Authors: Weintraub Sheri M. , Salter Bill J. , Chevalier C. Lynn , Ransdell Sarah 
Published: September 2021

AbstractBackground and purposeIncident learning can reveal important opportunities for safety improvement, yet learning from error is challenged by a number of human factors. In this study, incident learning reports have been analyzed with the human factors analysis classification system (HFACS) to uncover predictive patterns of human contributing factors.Materials and methodsSixteen hundred reports from the Safety in Radiation Oncology incident learning system were filtered for inclusion ultimately yielding 141 reports. A radiotherapy‐specific error type was assigned to each event as were all reported human contributing factors. An analysis of associations between human contributing factors and error types was performed.ResultsMultiple associations between human factors were found. Relationships between leadership and risk were demonstrated with supervision failures. Skill‐based errors (those done without much thought while performing familiar tasks) were found to pose a significant safety risk to the treatment planning process. Errors made during quality assurance (QA) activities were associated with decision‐based errors which indicate lacking knowledge or skills.ConclusionAn application of the HFACS to incident learning reports revealed relationships between human contributing factors and radiotherapy errors. Safety improvement efforts should include supervisory influences as they affect risk and error. An association between skill‐based and treatment planning errors showed a need for more mindfulness in this increasingly automated process. An association between decision and QA errors revealed a need for improved education in this area. These and other findings can be used to strategically advance safety.
Controlling the Multiple Chiroptical Inversion in Biphasic Liquid‐Crystalline Polymers
Authors: Cheng Xiaoxiao , Miao Tengfei , Ma Yafei , Zhu Xiaoyan , Zhang Wei , Zhu Xiulin 
Published: September 2021

AbstractWhile controlling the chirality and modulating the helicity is a challenging task, it attracts great research interest for gaining a better understanding of the origin of chirality in nature. Herein, structurally similar azobenzene (Azo) vinyl monomers were designed in which the alkyl chains comprised the chiral stereocenter with different achiral tail lengths. Combining the synchronous polymerization, supramolecular stacking and self‐assembly, the multiple chiroptical inversion of the Azo‐polymer supramolecular assemblies can be modulated by the tail length and DP of Azo blocks during in situ polymerization. The DP‐, UV light‐, temperature‐, aging time‐dependent chiroptical properties and liquid‐crystalline (LC) characterization indicated that the amorphous‐to‐LC phase transition and biphasic LC interconversion allow the transcription of intra‐chain π–π stacking, inter‐chainH‐ andJ‐aggregation, thereby controlling the dynamic multiple reversal of supramolecular chirality.
High‐Throughput Single‐Cell Mass Spectrometry Reveals Abnormal Lipid Metabolism in Pancreatic Ductal Adenocarcinoma
Authors: Liu Qinlei , Ge Wenjie , Wang Tongtong , Lan Jiayi , Martínez‐Jarquín Sandra , Wolfrum Christian , Stoffel Markus , Zenobi Renato 
Published: September 2021

AbstractEven populations of clonal cells are heterogeneous, which requires high‐throughput analysis methods with single‐cell sensitivity. Here, we propose a rapid, label‐free single‐cell analytical method based on active capillary dielectric barrier discharge ionization mass spectrometry, which can analyze multiple metabolites in single cells at a rate of 38 cells/minute. Multiple cell types (HEK‐293T, PANC‐1, CFPAC‐1, H6c7, HeLa and iBAs) were discriminated successfully. We found evidence for abnormal lipid metabolism in pancreatic cancer cells. We also analyzed gene expression in a cancer genome atlas dataset and found that the mRNA level of a critical enzyme of lipid synthesis (ATP citrate lyase, ACLY) was upregulated in human pancreatic ductal adenocarcinoma (PDAC). Moreover, both an ACLY chemical inhibitor and a siRNA approach targeting ACLY could suppress the viability of PDAC cells. A significant reduction in lipid content in treated cells indicates that ACLY could be a potential target for treating pancreatic cancer.
Surrogate model to screen for inactivation‐based clearance of enveloped viruses during biotherapeutics process development
Authors: Feroz Hasin , Cetnar Daniel , Hewlett Robert , Sharma Satish , Holstein Melissa , Ghose Sanchayita , Li Zheng Jian 
Published: September 2021

AbstractViral surrogates to screen for virus inactivation (VI) can be a faster, cheaper and safer alternative to third‐party testing of pathogenic BSL2 (Biosafety level 2) model viruses. Although the bacteriophage surrogate, Ø6, has been used to assess low pH BSL2 VI, it has not been used for evaluation of detergent‐mediated VI. Furthermore, Ø6 is typically assayed through host cell infectivity which introduces the risk of cross‐contaminating other cell lines in the facility. To circumvent contamination, we developed an in‐house RT‐qPCR (Reverse transcriptase quantitative polymerase chain reaction) assay for selective detection of active Ø6 from a population of live and dead phage. The RT‐qPCR assay was used to evaluate Ø6 inactivation in cell culture fluid of monoclonal antibody and fusion protein. Complementary Ø6 infectivity was also conducted at a third‐party testing facility. The Ø6 RT‐qPCR and infectivity data was modeled against VI of three BSL2 viruses, X‐ MuLV, A‐ MuLV and HSV‐1 in corresponding therapeutics. Both Ø6 methods demonstrate that any VI agent showing Ø6 clearance of a minimum of 2.5 logs would demonstrate complete BSL2 VI of ≥ 4.0 logs. Compared to BSL2 virus testing, this in‐house Ø6 RT‐qPCR tool can screen VI agents at 5% the cost and a turnaround time of 2 to 3 days vs. 4 to 7 months.
CRISPR‐Cas enzymes: The toolkit revolutionizing diagnostics
Authors: Verosloff Matthew S. , Shapiro Sarah J. , Hawkins Elizabeth M. , Alpay Emel , Verma Deepika , Stanfield Emma G. , Kreindler Lior , Jain Sonal , McKay Bridget , Hubbell Shae A. , Hendriks Carley G. , Blizard Benjamin A. , Broughton James P. , Chen Janice S. 
Published: September 2021

AbstractThe programmable nature of sequence‐specific targeting by CRISPR‐Cas nucleases has revolutionized a wide range of genomic applications and is now emerging as a method for nucleic acid detection. We explore how the diversity of CRISPR systems and their fundamental mechanisms have given rise to a wave of new methods for target recognition and readout. These cross‐disciplinary advances found at the intersection of CRISPR biology and engineering have led to the ability to rapidly generate solutions for emerging global challenges like the COVID‐19 pandemic. We further discuss the advances and potential for CRISPR‐based detection to have an impact across a continuum of diagnostic applications.
Pseudomonas putida KT2440 endures temporary oxygen limitations
Authors: Demling Philipp , Ankenbauer Andreas , Klein Bianca , Noack Stephan , Tiso Till , Takors Ralf , Blank Lars M. 
Published: September 2021

AbstractThe obligate aerobic nature of Pseudomonas putida, one of the most prominent whole‐cell biocatalysts emerging for industrial bioprocesses, questions its ability to be cultivated in large‐scale bioreactors, which exhibit zones of low dissolved oxygen tension. P. putida KT2440 was repeatedly subjected to temporary oxygen limitations in scale‐down approaches to assess the effect on growth and an exemplary production of rhamnolipids. At those conditions, the growth and production of P. putida KT2440 were decelerated compared to well‐aerated reference cultivations, but remarkably, final biomass and rhamnolipid titers were similar. The robust growth behavior was confirmed across different cultivation systems, media compositions, and laboratories, even when P. putida KT2440 was repeatedly exposed to dual carbon and oxygen starvation. Quantification of the nucleotides ATP, ADP, and AMP revealed a decrease of intracellular ATP concentrations with increasing duration of oxygen starvation, which can, however, be restored when re‐supplied with oxygen. Only small changes in the proteome were detected when cells encountered oscillations in dissolved oxygen tensions. Concluding, P. putida KT2440 appears to be able to cope with repeated oxygen limitations as they occur in large‐scale bioreactors, affirming its outstanding suitability as a whole‐cell biocatalyst for industrial‐scale bioprocesses.
Catalytic Hydrodeoxygenation of Model Bio‐oils Using HZSM‐5 and Ni2P/HZM‐5 Catalysts: Comprehension of Interaction
Authors: Wang Jundong , Abdelouahed Lokmane , Xu Jie , Brodu Nicolas , Taouk Bechara 
Published: September 2021

AbstractHydrodeoxygenation (HDO) of Mixture 1 (acetic acid and phenol) and Mixture 2 (acetone, acetic acid, phenol, 4‐ethylguaiacolis, furfural, and water) as model bio‐oils was performed to investigate the interactions. Ni2P/HZSM‐5 catalysts exhibited higher activity than blank HZSM‐5. The conversion rate of acetic acid enhanced with the increase of temperature, contrary to the value of phenol due to the differential adsorption capacity on active phases. Acetone can be formed by self‐ketonization of acetic acid. Low temperatures favored esterification, while high temperatures promoted the synthesis of alkyl‐substituted phenols and aromatic hydrocarbons via mainly alkyl substitution of phenol and benzene, respectively. Two reaction networks of model bio‐oil HDO with the main reactions were proposed.
Electrochemical Studies of CO2‐Reducing Metalloenzymes
Authors: Meneghello Marta , Léger Christophe , Fourmond Vincent 
Published: September 2021

AbstractOnly two enzymes are capable of directly reducing CO2: CO dehydrogenase, which produces CO at a [NiFe4S4] active site, and formate dehydrogenase, which produces formate at a mononuclear W or Mo active site. Both metalloenzymes are very rapid, energy‐efficient and specific in terms of product. They have been connected to electrodes with two different objectives. A series of studies used protein film electrochemistry to learn about different aspects of the mechanism of these enzymes (reactivity with substrates, inhibitors…). Another series focused on taking advantage of the catalytic performance of these enzymes to build biotechnological devices, from CO2‐reducing electrodes to full photochemical devices performing artificial photosynthesis. Here, we review all these works.
Development and Application of a Complete Active Space Spin‐Orbit Configuration Interaction Program Designed for Single Molecule Magnets
Authors: Bodenstein Tilmann , Heimermann Andreas , Fink Karin , van Wüllen Christoph 
Published: September 2021

AbstractWe present a spin‐orbit configuration interaction program which has been tailored for the description of the magnetic properties of polynuclear metal complexes with partially filled d‐ and f‐shells. The spin‐orbit operators are directly included in the configuration interaction program based on Slater‐determinants. The lowest states are obtained by a Block‐Davidson‐type diagonalisation. The usage of localised active orbitals enables the construction of start vectors from tensor products of single‐center wave functions that already include spin‐orbit interaction. This allows for an analysis of the role and the interplay of the different metal centres. Furthermore, in case of weak coupling of the metal centres these tensor products are already close to the final wave functions ensuring fast convergence. In combination with a two‐layer hybrid parallelisation, this makes the program highly efficient. Based on the spin‐orbit coupled wave functions, magnetic D‐tensors, g‐tensors and temperature‐dependent susceptibilities can be calculated. The applicability and performance of the program is shown exemplarily on a trinuclear transition metal (CoIIVIICoII) complex.
Cytological features of ovarian or tubal high‐grade serous carcinoma: A retrospective study of 12 cases with abnormal cervical liquid‐based smear
Authors: Xu Yanning , Liu Bingbing , Zhang Xiaojing , Chen Ling 
Published: September 2021

AbstractBackgroundHigh‐grade serous carcinoma (HGSC) is the most common epithelial carcinoma of the tubo‐ovarian region, with a poor prognosis, which presents with an advanced stage at the time of diagnosis. This study summarizes the cytological features of cervical liquid‐based cytological examination in order to diagnose ovarian or tubal HGSC at an early stage by cervical cytology smear.MethodsA total of 12 patients who were diagnosed with atypical glandular cell (AGC) and above lesions by cervical cytological examination and ovarian or tubal HGSC by histopathology were enrolled in this study. The cytological characteristics, including the arrangement and shape of the neoplastic cells, nuclear and cytoplasmic features, and the presence of tumor diathesis were reviewed.ResultsNine cases were determined to be AGC, and three cases were determined to be AGC favor neoplastic (AGC‐FN) in the 12 cervical cytological diagnoses. The glandular cells showed significant atypia and proliferated actively with a three‐dimensional structure. Increased nuclear‐to‐cytoplasmic ratios, prominent nucleoli, and hyperchromasia were common. Vacuole‐like changes were observed in the cytoplasm. Tumor diathesis was observed in only one case (1/12, 8.30%).ConclusionOvarian or tubal HGSC can occasionally be detected using cervical liquid‐based cytology. It has distinct cytological characteristics. Primary ovarian or tubal HGSC with positive cervical cytology was accompanied by tumor cells in ascites, which suggested that the patient had progressed to an advanced stage.
The dominant left ventricular assist device: lessons from an era
Authors: Alam Amit , Milligan Gregory P. , Gong Timothy 
Published: September 2021

AbstractThe production and distribution of the HeartWare ventricular assist device has come to an abrupt end, but with this end comes the opportunity to reflect upon lessons learned from its lifespan. Running counter to the standard of evidence‐based practice, the era of the HeartWare ventricular assist device was marred with fragmented data in relation to its primary counterpart, the HeartMate III. This created an incomplete understanding of devices, limited individualized patient care, and effectively positioned providers to make inferences regarding device superiority. We briefly review pertinent literature on this topic among the most commonly implanted durable devices from the era, detail the inherent limitations of this data, and argue the necessity of randomized clinical trials among novel devices towards the optimization of patient care.
Temperature and Counterion Dependent Spin Crossover in a Hexaamineiron(II) Complex
Authors: Connolly Blake J. P. , Brosius Victor , Mertes Nicole , Demidova Caroline , Bilyj Jessica K. , Riley Mark J. , Bernhardt Paul V. 
Published: September 2021

AbstractBased on previous results with [Fe(tame)2]Cl2.MeOH (tame=1,1,1‐tris(aminomethyl)ethane), which exhibits temperature dependent spin crossover, we report a series of isostructural rhombohedral salts [Fe(tame)2]X2.MeOH (X=Br−, ClO4−, BF4−) and examine their temperature dependent structures. In the case of [Fe(tame)2]Br2.MeOH, temperature dependent single crystal Vis‐NIR spectroscopy is reported as a complement to single crystal X‐ray diffraction results. The [Fe(tame)2]Br2.MeOH compound does show spin crossover behaviour but at very low temperatures (<100 K) and the spin active complex cation could not be converted exclusively to its low spin form even at 12 K. This is significantly different to its relative [Fe(tame)2]Cl2.MeOH which is entirely low spin at 60 K. The isostructural [Fe(tame)2]X2.nMeOH (X=ClO4− (n=0.5) and BF4− (n=1)) compounds show no spin crossover at the temperatures examined and remain exclusively in their high spin form. Removal of the MeOH solvent leads to another isostructural compound [Fe(tame)2](ClO4)2, which shows a remarkable reversible loss of crystallinity below 200 K that could be restored by warming to temperatures above 200 K. The fluoride and trifluoromethanesulfonate salts of [Fe(tame)2]2+ crystallise in monoclinic lattices and show no spin crossover behaviour.
Stereoselective Mannich Reaction of α‐Acetoxy‐β‐keto Esters with Isatin Imine: An Efficient Access to Vicinal Tetra‐Substituted Stereocenters
Authors: Kaur Jasneet , Preet Kaur Banni , Islam Nasarul , Chauhan Pankaj , Singh Chimni Swapandeep 
Published: September 2021

AbstractA highly diastereo‐ and enantioselective Mannich reaction of α‐acetoxy‐β‐keto esters with isatin imine was developed. The quinine thiourea organocatalyst smoothly promoted the asymmetric Mannich reaction to furnish various 3‐substituted‐3‐aminooxindole derivatives bearing two adjacent tetra‐substituted stereocenters in up to 93 % yield, up to 98 % ee with >20 : 1 dr. The transition state structure and absolute configuration of the obtained product were predicted using DFT calculations, and results from single crystal X‐ray analysis are in agreement with the DFT studies.