bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: An Efficient Technique-Based Distributed Energy Management for Hybrid MG System: A Hybrid SBLA-CGO Technique
Authors: Logeswaran T , Shajin Francis H , Rajesh Paulthurai 
Published: April 2021

Abstract
This manuscript presents an optimal energy management on microgrid (MG) connected to the grid that chooses the energy scheduling based on the proposed method. The present method is the joint implementation of the Side-Blotched Lizard Algorithm (SBLA) and the Chaos Game Optimization Algorithm (CGO) and hence it is named as SBLA-CGO method. Here, the MG system contains a photovoltaic system (PV), wind turbine (WT), battery storage (BS) and fuel cell (FC). Constantly, the necessary load demand of MG system connected to the grid is measured with SBLA method. The CGO increases the perfect match of MG with the expected load requirement. Moreover, renewable energy forecasting errors are evaluated twice by MG energy management for minimizing the control. Through the operation of MG schedule of several RES to decrease the electricity cost using the first method. Balancing the energy flow and minimize the effects of prediction errors according to the rule presented as planned power reference is second method. The main aim of the present method is evaluated with connection of fuel cost, the variation of energy per hour of the electrical grid, the cost of operation and maintenance of MG system connected to the network. According to RES, the energy demand and SOC of the storage elements are the conditions. Renewable energy system units use batteries as energy sources to allow them to operate continuously on stable and sustainable power generation. The analysis of the present method is analyzed by comparing with the other systems. The results of the comparison assess the strength of the present system and confirm their potential for solving the issues.
Centennial Records of PAHs and Black Carbon in Altay Mountain Peatlands, Xinjiang, China
Authors: Luo Nana , Bao Kunshan , Wen Bolong , Yu Rui , Tuoliuhan Yelebolat , Liu Xingtu 
Published: April 2021

Abstract
Black carbon (BC) and polycyclic aromatic hydrocarbons (PAHs) are often used to indicate anthropogenic impacts on natural environmental changes during the past century. In this study, a 30 cm peat core was collected from the Jiadengyu (JDY) peatland in Altay Mountain and dated by the 137Cs and 210Pb methods. The total organic carbon, BC and PAHs contents in JDY peat core were 17.09-47.16%, 1.14-67.14 mg g-1 and 260.58-950.98 ng·g-1, respectively. The δ13CBC ranged from -31.5‰ to -27.43‰, with an average of -30.52‰. Scanning electron microscope (SEM) showed that the BC particles in the peat were lumpy or irregular in shape and retained the structure of plant fiber. The PAHs ratios, δ13CBC and the SEM result indicated the dominant biomass combustion source of BC in the peatland. The BC content increased from 1950 to 1980 and decreased after 1980. The change of BC and δ13CBC is different from the national BC emission pattern, probably reflecting the impact of local agricultural exploration and thus crop burning increase.
How does benefit finding evolve over time among Chinese women breast cancer survivals: a longitudinal study
Authors: Bi Weiyun , Wang Huaning , Yang Guitao , Zhu Cailin 
Published: April 2021

Abstract
Objective: Even though the prevalence of benefit finding (BF) has been empirically shown to exist among breast cancer (BC) survivals, how does benefit finding evolve over time remains inadequately investigated. This objective of this study is to examine how BF evolves over time among Chinese breast cancer survivals and determine the demographic, medical and psychosocial factors that can sustain BF increase over time, thus bring about higher level of long-term post-traumatic growth among breast cancer survivals. Methods: Participants were 486 women with different stages of breast cancer (stages I, II and III) followed from completion of primary treatment. Analysis were performed on the data collected at the 3-year assessment during 2014-2019. Participants completed self-report questionnaires of characteristics and benefit finding at six time points with the interval of six months since BC diagnosis. The relationships between demographic, medical and psychosocial characteristics and benefit finding evolution over time were examined using mixed models. Results: Participants reported mixed results on the evolving patterns of benefit finding: 28% reported an upward trend in BF scoring over time, 49% instead reported an downward trend, and the remaining 23% reported no obvious change. Our study has shown that some well-known covariates of benefit finding, e.g. education, income, and social support, are not associated with BF trends. In comparison, levels of spirituality and disease coping at diagnosis can more reliably predict BF evolution over time. Our results strongly indicate that benefit finding can be sustained and increased by encouraging attempts at meaning-making and active disease coping during breast cancer treatment. To our knowledge, this study is among the first to examine trends of benefit finding evolution over time on breast cancer survivals and determine their psychosocial predictors in developing countries. Conclusion: Identifying the sustaining factors of benefit finding in the experience of breast cancer is the key to design psycho clinical solutions for patients’ long-term post-traumatic growth. As time goes by, cancer patients may experience less benefit finding. However, active disease coping and meaning-making by patients can effectively counter this undesired trend and boost their higher long-term post-traumatic growth.
Power Generation at Room Temperature
Authors: Kohata Haruki , Obinata Mitsugu , Ikeda Takumi , Sekiya Hayato , Mei Biao , Wang Ye , Mizukoshi Kazushi , Isobe Toshihiro , Nakajima Akira , Matsushita Sachiko 
Published: April 2021

Abstract
The effective utilisation of thermal energy is crucial to a world aiming at sustainable development goals. The sensitised thermal cell (STC) is a new thermal energy conversion technology, which was reported in 2017, for generating electricity via the redox reactions of electrolyte ions with thermally excited carriers in semiconductors. STC is attracting attention as a technology that could affect oil prices globally. Here, we report the successful construction of STC, which discharges and recovers well at room temperature, by studying the interelectrode and ion diffusion distances. The fabricated STC is thinner than 0.5 mm and can be rendered flexible. Further, STCs, which possess a power generation capacity of 0.1 microA, 100 mV per 1 mm2 area, and shall be installed “in” internet-of-things (IoT) devices, drainage pipes, and walls in the future.
Colchicine-Containing Nanoparticles Attenuates Acute Myocardial Infarction Injury by Inhibiting Inflammation
Authors: Wang Li , Peng Yun-fan , Song Li-jun , Xia Da-sheng , Li Chao , Li Zhu-qing , Li Qi , Yu Ao , Lu Cheng-zhi , Wang Yongjian 
Published: April 2021

Abstract
Purpose

Anti-inflammatory therapy is important for reducing myocardial injury after acute myocardial infarction (MI). New anti-inflammatory drugs and their mechanism are necessary to be explored to improve the clinical efficacy. We aimed to improve the efficacy of colchicine on attenuating MI injury by nano-drug delivery systems, and to investigate the mechanism of anti-inflammatory.
Methods

Colchicine-containing delivery system based on calcium carbonate nanoparticles (ColCaNPs) was synthesized. The protection against MI by ColCaNPs was evaluated using an in vivo rat model established by ligating the left anterior descending coronary artery. Macrophage polarization and the levels of inflammatory cytokines were determined using immunohistochemistry, western blot and ELISA analysis.
Results

ColCaNPs treatment showed about a 45% reduction in myocardial infarct size and attenuating myocardial fibrosis compared with groups without drug intervention after MI. Furthmore, ColCaNPs significantly decreased the levels of CRP, TNF-α and IL-1β in serum and the expression of proinflammatory cytokine in myocardial tissues after MI (p < 0.05). We also found that ColCaNPs notably restrained pyroptosis, and inhibited inflammatory response by modulating on M1/M2 macrophage polarization and suppressing TLR4/NFκB/NLRP3 signal pathway.
Conculsion

Colchicine-containing nanoparticles can protect against MI injury in a clinically relevant rat model by reducing inflammation. In addition, calcium carbonate nanoparticles can increase the cardioprotective effects of colchicine.
PD-1/PD-L1-negative tracheal mucoepidermoid carcinoma: A case report and systematic review of the literature
Authors: Liu Ying Ying , Guo Jian , Chen Ji , Li Hai Xia , Wang Zeng Tao , Liu Jie , Gong Yi 
Published: April 2021

Abstract
Background: Tracheal mucoepidermoid carcinoma is a rare form of non-small cell lung carcinoma and is defined as a tumor characterized by a combination of squamous, mucus-secreting, and intermediate cell types. This carcinoma is usually located in the lobar or segmental bronchus. Currently, surgery is the preferred treatment for this disease, which includes pneumonectomy, lobectomy, and sleeve lobectomy. Case presentation: A 50-year-old Chinese male presented with cough, shortness of breath and hemoptysis, and the effect of antibiotic therapy was not good. Subsequently, the airway occupied lesion was found by chest CT, and he was transferred to our hospital for surgical resection. Histologically, the tumor contained squamous epidermal cells, mucoepidermoid cells and intermediate cells. Immunohistochemistrically, the tumor cells were positive for p63, CK5/6, CK7 and Ki67. However, the tumor is generally negative for TTF-1 and neuroendocrine markers. The patient had no recurrence 15 months after the surgery.Conclusions: We report a rare case of mucoepidermoid carcinoma in the distal trachea in which the surgery was difficult and could not be performed like a traditional pulmonary resection. We first provide a comprehensive description of airway management and anesthesia intubation. After surgery, we reviewed the literature and found that PD-1/PD-L1 detection had never been reported in tracheal mucoepidermoid carcinoma. Therefore, we studied the PD-1/PD-L1 pathway in this patient, and the results were negative, which may indicate that potential adjuvant therapy with immune checkpoint inhibitors (ICIs) is not useful in this case.
All-oxide-based high-mobility planar PN junctions and tunnelling field effect transistor
Authors: Anh Le Duc , Wijaya Theodorus , Kaneta Shingo , Seki Munetoshi , Tabata Hitoshi , Tanaka Masaaki , Ohya Shinobu 
Published: April 2021

Abstract
Electronics based on perovskite oxides, a class of materials with unparalleled wealth of physical functionalities, possesses high potential to go beyond the present semiconductor-based technologies. Towards universal and scalable oxide-based electronics, an important milestone is to realise both N- and P-type conduction regions – the two fundamental blocks of most of electronic devices – on the same oxide substrate surface. However, in contrast to the case of conventional semiconductors, the formation of planar PN junctions is highly challenging in oxide materials owing to difficulties in carrier doping. Here, we show that high-mobility PN junctions can be formed on a surface of SrTiO3 (STO), one of the most versatile oxide materials, in a robust and low-cost manner by simply depositing Angstrom-thin metal layers on top of an STO substrate near room temperature. Furthermore, by forming planar N-P-N junctions, we successfully demonstrate a new type of oxide-based tunnelling field effect transistor (TFET), which enables an extremely sharp switching with a subthreshold swing value S ~ 38 mV/dec and a large current ON/OFF ratio of 108. This high-performance FET operation is obtained by a new mechanism where a gate voltage strongly modulates the tunnelling probability through the depletion layers at the PN interfaces, utilising the unique strong nonlinear electric-field dependence of the permittivity of STO. Our simple method for selectively forming P and N-type regions monolithically on STO is potentially applicable to a wide range of oxide-based electronic systems, from single devices to integrated circuits, and even to flexible electronics.
Performance Enhancement of Solar Photovoltaic (PV) Module Using a Novel Flat Plate (NFP) Glass Cover by Reducing the Effect of Bird Dropping (BD) Settlement
Authors: Sisodia Anil kumar , Mathur Ram kumar 
Published: April 2021

Abstract
A massive BDs deposition on the common rectangular flat plate (RFP) of photovoltaic (PV) module is a matter of great concern in Western Rajasthan (WR) that diminish the overall energy production capacity of the system remarkably. In this research article, a prototype NFP design of a front glass cover of PV module is proposed to prevent the impact of BD settlement by the restriction of bird’s sitting/movement on the front glass cover. In this regard, the performance analysis of PV module with common RFP and newly designed NFP glass covers has been assessed at the different inclination β° (0- 90). The BD accumulation onto the both glass cover explored by the optical transmittance profiles at the different tilt angles, i.e., explained by bird movement on each flat glass surfaces. Consequently, a significant amount of output electric energy has been gained in NFP design rather than RFP corresponding to particular tilt regions TR I (0° ≤ β ≤ 25°), TR II (25° ≤ β ≤ 60°), and TR III (60° ≤ β ≤ 90°). According to the results achieved, an excellent level of improvement in average power loss, ~ 97.85%, corresponding to optimal TR(III) has been detected by employing NFP glass collector.
Identification of mRNA and Long Non-Coding RNA Expression Profiles in Developing Yorkshire Pig Spleens
Authors: Li Xinjian , Han Xuelei , Sun Caixia , Li Gaiying , Wang Kejun , Li Xiuling , Qiao Ruimin 
Published: April 2021

Abstract
Background: Epidemic diseases cause great economic loss in pig farms each year, some of which are characterized mainly in spleen. Yorkshire pig is the most popular used first dam in the commercial pork production system. But the mRNA and lncRNA expression networks in developing Yorkshire pig spleens remain obscure. Results: Here, we profiled the systematic characters of mRNA and lncRNA repertoires in three groups of spleens from nine Yorkshire pigs, each three aged at 7 days, 90 days and 180 days. By using a precise mRNA and lncRNA identification pipeline, we identified 19,647 genes and 219 known and 3,219 putative lncRNA transcripts, 1,729 genes and 64 lncRNAs therein were found to express differentially in three groups. Gene expression characteristics of genes and lncRNAs were found to be basically fixed before 90 days after birth. Enrichment analysis of differentially expressed genes and potential target genes of differentially expressed lncRNAs both displayed crucial roles of up-regulation in immune activation and hematopoiesis and down-regulation in cell replication and division in 90 and 180 days compared to 7 days. The unregulated terms and their significance levels in 90 and 180 days both showed an extremely high degree of consistency. ENSSSCT00000001325 was the only lncRNA transcript that existed in three groups. CDK1, PCNA and PLK were detected to be hub genes that varied with age. BNIP3L, IL5, CD38 and TGFβ1 were found to be common top regulators from 7 to 90 and 180 days while ERAP1, NLRC5 and IL2RG were top regulators from 90 to 180 days.Conclusions: This study provided the first mRNA and lncRNA expression profiles in Yorkshire spleens at three developmental stages. We established gene expression modules and networks in the spleen of pigs from immune system initiation to adulthood. Our results are helpful for the study of transcriptome and functional genomics of spleen tissue in farm animals.
3-D Generated Anatomic Custom Talar Cement Spacers: Case Reports, Technical Tips and Literature Review
Authors: Broughton Kimberly K , Chien Bonnie , Stenquist Derek , Williams Caroline , Miller Christopher , Kwon John Y. 
Published: April 2021

Abstract
Background: With today’s expanding use of total ankle arthroplasty, the ever-present trauma patient, and patients with uncontrolled comorbid conditions, surgeons face significant challenges for lower extremity reconstruction. These patients highlight some of those who may present with unique anatomy, bone loss, infection, and various other local and systemic factors that affect treatment options for successful outcomes. Three dimensional (3-D) printing for medical devices is allowing for new and customized ways to meet patient and surgeon goals of limb salvage and reconstruction. Case Presentations: While the majority of 3-D printing is done for the purpose of implantation, we present a technical tip for designing a 3-D printed mold from which to create an antibiotic cement spacer for implantation. With two case illustrations including a talus fracture nonunion and infected subtalar arthrodesis nonunion, we describe the process of patient selection, implant design, fabrication, and implantation of a custom molded antibiotic cement talus. Discussion: Case illustrations present two successful limb salvage patients while giving a thorough explanation of our technique, learned tips and tricks. This applied technology builds on prior use of antibiotic cement in limb salvage of the lower extremity, most of which are joint sacrificing. 3-D printing the mold for an anatomic talus cement spacer results in a joint sparing limb salvage solution.Innovative 3-D printing technology is merged with current, pertinent literature regarding antibiotic cement to offer surgeons expanded options for temporary or definitive reconstructive techniques in some of the most challenging patients.
Could the Storage Time Post-collection Affect the Post-thaw Motility and Fertilizing Ability of Mediterranean Brown Trout Semen?
Authors: Rusco Giusy , Iorio Michele Di , Iampietro Roberta , Roncarati Alessandra , Esposito Stefano , Iaffaldano Nicolaia 
Published: April 2021

Abstract
The aim of this study was to evaluate the effect of different cool storage time intervals between collection and semen freezing on both fresh and cryopreserved semen motility parameters and the post-thaw fertilizing ability of Mediterranean brown trout semen. The ejaculates were split into six aliquots and stored on ice for 1 to 6 hours, until freezing. Fresh and post-thawing sperm motility were evaluated by Computer-Assisted Sperm Analysis system, whilst the fertilizing ability was assessed by in vivo trials. In fresh semen, at 3 h of storage, a significant decrease of total motility, linear movement (STR, LIN) and beat cross frequency was recorded, whilst the amplitude of lateral displacement of the spermatozoon head underwent a significant increase. Velocity parameters (VCL, VAP and VSL) were not affected by the cold storage time, whilst the duration of sperm movement was significantly higher at 1h compared to the other times tested. Freezing procedure overall decreased almost all post-thaw sperm motility parameters, however no significant differences was observed over time, both in term of fast and linear movement. Cool storage time did not significantly affect the percentage of post-thaw eyed embryos. Our results showed that Mediterranean brown trout semen can be stored on ice even up to 6 hours before freezing, without decreasing its post-thawing quality and fertilizing ability.
Publication of Clinical Trials on Medicinal Products: A Follow-Up Study
Authors: Sándor-Bajusz Kinga Amália , Kraut Andrea , Baasan Odgerel , Márovics Gergely , Berényi Károly , Lohner Szimonetta 
Published: April 2021

Abstract
Background: Clinical research should provide reliable evidence to clinicians, health policy makers and researchers, which is only possible once the results are made transparently available. The present research aims to investigate factors influencing publication rates, time and characteristics of clinical trials on medicinal products and to assess the degree of accessibility of trial results on a country level.Methods: Clinical trials authorized in Hungary in the year of 2012 were followed until publication and/or June 2020. Corresponding scientific publications were searched via clinical trial registries, Pubmed (MEDLINE) and Google.Results: Out of 330 clinical trials authorized in 2012, a total of 232 trials were completed for more than 1 year in June 2020. The proportion of industry-initiation was high (97%). Time to publication was 21 (22) months [median (IQR)]. Time to publication was significantly shorter when trials involved both European and non-European countries (p<0.001), and when registered in both EU CTR and clinicaltrials.gov (p<0.001) based on survival analyses. A significant amount (24.1%) of unpublished clinical trial results were accessible in a trial register. A total of 70.93% of available publications were published “open access”.Publications with domestic co-authors contribute to the research output of a country. In our study only 21.5% of the identified publications had a Hungarian author.Conclusions: We encourage academic researchers to plan, register and conduct trials on medicinal products. Registries should be considered as an important source of information of clinical trials results. Measurable domestic scientific impact of trials on medicinal products need further improvement.
Impact of Mild Aortic Valve Disease on Late Outcomes after Replacement of the Ascending Aorta Case-control Study
Authors: Nakamura Ken , Orii Kouan , Kondo Taichi , Nakao Mitsutaka , Wakatabe Makoto , Hashimoto Kazuhiro , Kunihara Takashi 
Published: April 2021

Abstract
Background: The time course of mild aortic valve disease after replacement of the ascending aorta is unclear. We sought to clarify it.Methods: Between January 2011 and December 2016, 26 patients (9 bicuspid and 17 tricuspid aortic valve disease) underwent replacement of the enlarged ascending aorta alone. We compared the postoperative disease course between bicuspid and tricuspid aortic valve by transthoracic echocardiography and computed tomography performed at 73 ± 23 and 60 ± 23 months post-surgery, respectively.Results: The bicuspid group was younger than the tricuspid group (62.1 ± 4.8 vs 73.3 ± 4.8 years). Pathophysiology predominantly involved aortic valve stenosis and regurgitation in the bicuspid and tricuspid group, respectively. The peak and mean pressure gradient increased (P = .16, and P = .46) and the aortic valve area decreased significantly in the bicuspid group (P = .005). Two patients in the bicuspid group who required re-operation had an aortic valve area of 1.2 cm2 at initial operation. Seventy percent of patients in the tricuspid group had less than mild aortic valve regurgitation preoperatively, which improved up to 82% at follow-up. Freedom from re-operation was 66.7% and 100% at 8 years for the bicuspid and tricuspid group, respectively. Conclusions: Aortic valve replacement may be considered for patients with bicuspid aortic valve stenosis if the aortic valve area is less than 1.2 cm2, even if the general diagnosis is mild aortic valve stenosis at initial surgery. Even mild aortic valve regurgitation may be improved by surgical intervention in the ascending aorta.