bluuebunny/crossref_metadata_2025_split huggingface dataset:
The application of WHO ICD-PM: Feasibility for the classification of timing and causes of perinatal deaths in a busy birth centre in a low-income country
Authors: Housseine Natasha , Snieder Anne , Binsillim Mithle , Meguid Tarek , Browne Joyce L. , Rijken Marcus J. 
Published: January 2021

Objective
To assess the feasibility of the application of International Classification of Diseases-10—to perinatal mortality (ICD-PM) in a busy low-income referral hospital and determine the timing and causes of perinatal deaths, and associated maternal conditions.

Design
Prospective application of ICD-PM.

Setting
Referral hospital of Mnazi Mmoja Hospital, Zanzibar, United Republic of Tanzania.

Population
Stillbirths and neonatal deaths with a birth weight above 1000 grams born between October 16th 2017 to May 31st 2018.

Methods
Clinical information and an adapted WHO ICD-PM interactive excel-based system were used to capture and classify the deaths according to timing, causes and associated maternal complications. Descriptive analysis was performed.

Main outcome measures
Timing and causes of perinatal mortality and their associated maternal conditions.

Results
There were 661 perinatal deaths of which 248 (37.5%) were neonatal deaths and 413 (62.5%) stillbirths. Of the stillbirths, 128 (31%) occurred antepartum, 129 (31%) intrapartum and for 156 (38%) the timing was unknown. Half (n = 64/128) of the antepartum stillbirths were unexplained. Two-thirds (67%, n = 87/129) of intrapartum stillbirths followed acute intrapartum events, and 30% (39/129) were unexplained. Of the neonatal deaths, 40% died after complications of intrapartum events.

Conclusion
Problems of documentation, lack of perinatal death audits, capacity for investigations, and guidelines for the unambiguous objective assignment of timing and primary causes of death are major threats for accurate determination of timing and specific primary causes of perinatal deaths.
Dynamics of water conveying zinc oxide through divergent-convergent channels with the effect of nanoparticles shape when Joule dissipation are significant
Authors: Rashid Umair , Iqbal Azhar , Liang Haiyi , Khan Waris , Ashraf Muhammad Waqar 
Published: January 2021

Aim of study
The shape effects of nanoparticles are very significant in fluid flow and heat transfer. In this paper, we discuss the effects of nanoparticles shape in nanofluid flow between divergent-convergent channels theoretically. In this present study, various shapes of nanoparticles, namely sphere, column and lamina in zinc oxide-water nanofluid are used. The effect of the magnetic field and joule dissipation are also considered.

Research methodology
The system of nonlinear partial differential equations (PDEs) is converted into ordinary differential equations (ODES). The analytical solutions are successfully obtained and compared with numerical solutions. The Homotopy perturbation method and NDsolve method are used to compare analytical and numerical results respectively.

Conclusion
The results show that the lamina shape nanoparticles have higher performance in temperature disturbance and rate of heat transfer as compared to other shapes of nanoparticles.
Source identification of infectious diseases in networks via label ranking
Authors: Zhou Jianye , Jiang Yuewen , Huang Biqing 
Published: January 2021

BackgroundOutbreaks of infectious diseases would cause great losses to the human society. Source identification in networks has drawn considerable interest in order to understand and control the infectious disease propagation processes. Unsatisfactory accuracy and high time complexity are major obstacles to practical applications under various real-world situations for existing source identification algorithms.MethodsThis study attempts to measure the possibility for nodes to become the infection source through label ranking. A unified Label Ranking framework for source identification with complete observation and snapshot is proposed. Firstly, a basic label ranking algorithm with complete observation of the network considering both infected and uninfected nodes is designed. Our inferred infection source node with the highest label ranking tends to have more infected nodes surrounding it, which makes it likely to be in the center of infection subgraph and far from the uninfected frontier. A two-stage algorithm for source identification via semi-supervised learning and label ranking is further proposed to address the source identification issue with snapshot.ResultsExtensive experiments are conducted on both synthetic and real-world network datasets. It turns out that the proposed label ranking algorithms are capable of identifying the propagation source under different situations fairly accurately with acceptable computational complexity without knowing the underlying model of infection propagation.ConclusionsThe effectiveness and efficiency of the label ranking algorithms proposed in this study make them be of practical value for infection source identification.
Assessing the applicability of the new Global Lung Function Initiative reference values for the diffusing capacity of the lung for carbon monoxide in a large population set
Authors: Wardyn Pierre-Marie , de Broucker Virginie , Chenivesse Cécile , Sobaszek Annie , Van Bulck Richard , Perez Thierry , Edmé Jean-Louis , Hulo Sébastien 
Published: January 2021

Background
The single-breath diffusing capacity of the lung for carbon monoxide (DLCO) interpretation needs the comparison of measured values to reference values. In 2017, the Global Lung Function Initiative published new reference values (GLI-2017) for DLCO, alveolar volume (VA) and transfer coefficient of the lung for carbon monoxide (KCO). We aimed to assess the applicability of GLI-2017 reference values for DLCO on a large population by comparing them to the European Community of Steel and Coal equations of 1993 (ECSC-93) widely used.

Methods
In this retrospective study, spirometric indices, total lung capacity, DLCO, VA and KCO were measured in adults classified in 5 groups (controls, asthma, chronic bronchitis, cystic fibrosis, and interstitial lung diseases (ILD)). Statistical analysis comparing the 2 equations sets were stratified by sex.

Results
4180 tests were included. GLI-2017 z-scores of the 3 DLCO indices of the controls (n = 150) are nearer to 0 (expected value in a normal population) than ECSC-93 z-scores. All groups combined, in both genders, DLCO GLI-2017 z-scores and %predicted are significantly higher than ECSC z-scores and %predicted. In the ILD group, differences between the 2 equation sets depend on the DLCO impairment severity: GLI-2017 z-scores are higher than ECSC z-scores in patients with no or “mild” decrease in DLCO, but are lower in “moderate” or “severe” decrease.

Conclusion
GLI-2017 reference values for DLCO are more suitable to our population and influence the diagnostic criteria and severity definition of several lung diseases.
Comparison of obesity and metabolic syndrome prevalence using fat mass index, body mass index and percentage body fat
Authors: Wong Joseph C. , O’Neill Sheila , Beck Belinda R. , Forwood Mark R. , Khoo Soo Keat 
Published: January 2021

Background
Accurate obesity classification is important so that appropriate intervention can be instituted to modify metabolic risk factors. Commonly utilized body mass index (BMI) and percentage body fat (PBF) are influenced by lean mass whereas fat mass index (FMI) measures only body fat. This study compares the prevalence of obesity and metabolic risk factors with FMI, BMI and PBF using DXA (dual-energy x-ray absorptiometry).

Methods
489 women randomly recruited from the electoral roll were stratified into 4 age groups; 40–49, 50–59, 60–69 and 70–79 years from 2000 to 2001. Clinical data and DXA body composition were obtained. Statistical analyses were performed using Medcalc v15 (Ostend, Belgium) with significance level at p = 0.05 (two-tailed).

Results
There was higher prevalence of obesity using PBF compared to BMI and FMI (p<0.001). This difference was greater from age 50–59 (p<0.05) which may be explained by age-related lean mass loss. PBF over-classified obesity in over 35% of normal and 95% of overweight categories compared to FMI and BMI. BMI has a sensitivity of 78.9% and specificity of 98.3% for obesity using FMI as the standard. BMI under-classified obesity in the overweight category by 14.9% compared to FMI. There was no difference in diabetes, dyslipidemia, hypertension and metabolic syndrome prevalence within the BMI-obesity and FMI-obesity categories (p>0.05).

Conclusion
PBF classified more obesity than BMI and FMI because of its low pre-determined threshold. The greater difference with PBF compared to BMI and FMI from the 50–59 decade onwards can be attributed to age-related lean mass loss. BMI had the lowest sensitivity for obesity diagnosis. BMI under-classified obesity in the overweight category compared to FMI due to its inability to differentiate lean mass. However, there was no significant difference in the prevalence of metabolic risk factors between BMI and FMI-obesity categories indicating that fat location may influence metabolic dysregulation.
Impact of integrating objective structured clinical examination into academic student assessment: Large-scale experience in a French medical school
Authors: Matet Alexandre , Fournel Ludovic , Gaillard François , Amar Laurence , Arlet Jean-Benoit , Baron Stéphanie , Bats Anne-Sophie , Buffel du Vaure Celine , Charlier Caroline , De Lastours Victoire , Faye Albert , Jablon Eve , Kadlub Natacha , Leguen Julien , Lebeaux David , Malmartel Alexandre , Mirault Tristan , Planquette Benjamin , Régent Alexis , Thebault Jean-Laurent , Dinh Alexy Tran , Nuzzo Alexandre , Turc Guillaume , Friedlander Gérard , Ruszniewski Philippe , Badoual Cécile , Ranque Brigitte , Oualha Mehdi , Courbebaisse Marie 
Published: January 2021

Purpose
Objective structured clinical examinations (OSCE) evaluate clinical reasoning, communication skills, and interpersonal behavior during medical education. In France, clinical training has long relied on bedside clinical practice in academic hospitals. The need for a simulated teaching environment has recently emerged, due to the increasing number of students admitted to medical schools, and the necessity of objectively evaluating practical skills. This study aimed at investigating the relationships between OSCE grades and current evaluation modalities.

Methods
Three-hundred seventy-nine 4th-year students of University-of-Paris Medical School participated to the first large-scale OSCE at this institution, consisting in three OSCE stations (OSCE#1–3). OSCE#1 and #2 focused on cardiovascular clinical skills and competence, whereas OSCE#3 focused on relational skills while providing explanations before planned cholecystectomy. We investigated correlations of OSCE grades with multiple choice (MCQ)-based written examinations and evaluations of clinical skills and behavior (during hospital traineeships); OSCE grade distribution; and the impact of integrating OSCE grades into the current evaluation in terms of student ranking.

Results
The competence-oriented OSCE#1 and OSCE#2 grades correlated only with MCQ grades (r = 0.19, P<0.001) or traineeship skill grades (r = 0.17, P = 0.001), respectively, and not with traineeship behavior grades (P>0.75). Conversely, the behavior-oriented OSCE#3 grades correlated with traineeship skill and behavior grades (r = 0.19, P<0.001, and r = 0.12, P = 0.032), but not with MCQ grades (P = 0.09). The dispersion of OSCE grades was wider than for MCQ examinations (P<0.001). When OSCE grades were integrated to the final fourth-year grade with an incremental 10%, 20% or 40% coefficient, an increasing proportion of the 379 students had a ranking variation by ±50 ranks (P<0.001). This ranking change mainly affected students among the mid-50% of ranking.

Conclusion
This large-scale French experience showed that OSCE designed to assess a combination of clinical competence and behavioral skills, increases the discriminatory capacity of current evaluations modalities in French medical schools.
Three-dimensional geometric morphometric studies of modern human occipital variation
Authors: Zhang Yameng , Schepartz Lynne A. 
Published: January 2021

ObjectivesTo investigate three-dimensional morphological variation of the occipital bone between sexes and among populations, to determine how ancestry, sex and size account for occipital shape variation and to describe the exact forms by which the differences are expressed.MethodsCT data for 214 modern crania of Asian, African and European ancestry were compared using 3D geometric morphometrics and multivariate statistics, including principal component analysis, Hotelling’s T2test, multivariate regression, ANOVA, and MANCOVA.ResultsSex differences in average occipital morphology are only observed in Europeans, with males exhibiting a pronounced inion. Significant ancestral differences are observed among all samples and are shared by males and females. Asian and African crania have smaller biasterionic breadths and flatter clivus angles compared to Europeans. Asian and European crania are similar in their nuchal and occipital plane proportions, nuchal and occipital angles, and lower inion positions compared to Africans. Centroid size significantly differs between sexes and among populations. The overall allometry, while significant, explains little of the shape variation. Larger occipital bones were associated with a more curved occipital plane, a pronounced inion, a narrower biasterionic breadth, a more flexed clivus, and a lower and relatively smaller foramen magnum.ConclusionsAlthough significant shape differences were observed among populations, it is not recommended to use occipital morphology in sex or population estimation as both factors explained little of the observed variance. Other factors, relating to function and the environment, are suggested to be greater contributors to occipital variation. For the same reason, it is also not recommended to use the occiput in phylogenetic studies.
Analysis of type material of Opephora pacifica and emendation of the genus Opephora (Bacillariophyta)
Authors: Morales Eduardo A. , Wetzel Carlos E. , Ector Luc , Van de Vijver Bart 
Published: January 2021

Abstract
The genus Opephora currently contains 37 species and 27 infraspecific taxa. However, the existing literature reveals a wide morphological diversity and the need to establish defining characters to circumscribe the genus as a cohesive and, perhaps, monophyletic group. The type material of Opephora pacifica, the generitype, is analysed. We emend the description of both the species and the genus, the latter also based on published light and scanning electron microscopy observations of closely related species. After review of the available literature, we determined that currently only two species can be ascribed with certainty to the genus Opephora: O. pacifica and O. marina. Based on available literature, it is highly likely that O. fragilarioides also belongs to this genus. We present a table with all known species and infraspecific taxa and make comments regarding their recent transfer to other genera, their current accepted nomenclature, and the genus to which they should probably be ascribed pending the collection of further information.
Design of new activated carbon based adsorbents for improved desulfurization of heavy gas oil: experiments and kinetic modeling
Authors: Nawaf Amer T. , Jarullah Aysar T. , Hameed Shymaa A. , Mujtaba Iqbal M. 
Published: January 2021

Abstract
In this work, adsorption desulfurization is considered for making cleaner fuel. New efficient adsorbents have been designed by using two active metal oxides mainly potassium permanganate (KMnO4) and potassium phosphate (KPO4·3H2O) on Activated Carbon (AC). Ultrasonic assisted impregnation method (IWI) is used in designing the adsorbents offering high pore volume, pore size, surface chemistry, and high surface area. Use of ultrasonic method increases the dispersion of the active material (groups) on AC leading to increased number of collisions between O-atom on AC-support resulting in high sulfur removal from fuel. KMnO4 on AC shows higher adsorption capacity towards sulfur than KPO4·3H2O at the same operating conditions. New results with respect to sulfur removal has obtained compared with those obtained by previous studies. Finally, the adsorption kinetic parameters of such process are developed. Thomas and Yoon–Nelson models and the experimental data are used for this purpose using linear and non-linear regression analysis. Yoon–Nelson kinetic model fits well with the experiments data better than Thomas kinetic model in the entire adsorption column system.
Seawater degradation of PLA accelerated by water-soluble PVA
Authors: Huang Dan , Hu Zhi-De , Liu Tian-Yuan , Lu Bo , Zhen Zhi-Chao , Wang Ge-Xia , Ji Jun-Hui 
Published: January 2021

Abstract
In order to promote the degradation of PLA in seawater, a series of seawater-degradable polyester blends PVA/PLA were prepared by blending biodegradable polylactic acid (PLA) with water-soluble modified polyvinyl alcohol (PVA) in this paper. ADR 4370S was introduced to bring a certain degree of improvement in compatibility of PVA/PLA blends. The results of degradation test in natural seawater for 180 days show that the weight loss of PVA/PLA blends in seawater is much higher compared with that of pure PLA. PVA can be used as an effective hydrolysis accelerator for PLA matrix, helping to significantly reduce the molecular weight of PLA. The channels caused by dissolution/swelling of PVA facilitate the entry of water and microorganisms into the materials to contact with PLA, thereby promoting the degradation process of PLA matrix itself. Thus, both dissolution/swelling of PVA and degradation of PLA occur in PVA/PLA blends, and the degree of rapid dissolution of PVA in the early stage determines the degree of degradation of PLA.
Acid red G dye removal from aqueous solutions by porous ceramsite produced from solid wastes: Batch and fixed-bed studies
Authors: Li Tianpeng , Fan Jing , Sun Tingting 
Published: January 2021

AbstractA novel porous ceramsite was made of municipal sludge, coal fly ash, and river sediment by sintering process, and the performance of batch and fixed-bed column systems containing this material in the removal of acid red G (ARG) dye from aqueous solutions was assessed in this study. The results of orthogonal test showed that sintering temperature was the most important determinant in the preparation of porous ceramsite, and it possesses developed pore structure and high specific surface area. Batch experiment results indicated that the adsorption process of ARG dye toward porous ceramsite was a spontaneous exothermic reaction, which could be better described with Freundlich–Langmuir isotherm model (R2 > 0.992) and basically followed the pseudo-first-order kinetic equation (R2 > 0.993). Column experiment results showed that when the porous ceramsite was used as packing material, its adsorption capacity was roughly improved by 3.5 times compared with that in batch system, and the breakthrough behavior was simulated well with Yoon–Nelson model, with R2 > 0.954. This study suggested that the novelty man-made porous ceramsite obtained from solid wastes might be processed as a certain cost-effective treatment material fit for the dye removal in aqueous solutions.
Vorinostat exhibits anticancer effects in triple-negative breast cancer cells by preventing nitric oxide-driven histone deacetylation
Authors: Palczewski Marianne B. , Kuschman Hannah Petraitis , Bovee Rhea , Hickok Jason R. , Thomas Douglas D. 
Published: January 2021

Abstract
Triple-negative breast cancers (TNBC) that produce nitric oxide (NO) are more aggressive, and the expression of the inducible form of nitric oxide synthase (NOS2) is a negative prognostic indicator. In these studies, we set out to investigate potential therapeutic strategies to counter the tumor-permissive properties of NO. We found that exposure to NO increased proliferation of TNBC cells and that treatment with the histone deacetylase inhibitor Vorinostat (SAHA) prevented this proliferation. When histone acetylation was measured in response to NO and/or SAHA, NO significantly decreased acetylation on histone 3 lysine 9 (H3K9ac) and SAHA increased H3K9ac. If NO and SAHA were sequentially administered to cells (in either order), an increase in acetylation was observed in all cases. Mechanistic studies suggest that the “deacetylase” activity of NO does not involve S-nitrosothiols or soluble guanylyl cyclase activation. The observed decrease in histone acetylation by NO required the interaction of NO with cellular iron pools and may be an overriding effect of NO-mediated increases in histone methylation at the same lysine residues. Our data revealed a novel pathway interaction of Vorinostat and provides new insight in therapeutic strategy for aggressive TNBCs.
Friction stir lap welding thin aluminum alloy sheets
Authors: Wang Tao , Gong Xue , Ji Shude , Xue Gang , Lv Zan 
Published: January 2021

AbstractIn this work, thin aluminum alloy sheets with thickness of 0.8 mm were friction stir lap welded using small shoulder plunge depths of 0 and 0.1 mm. The joint formation, microstructure and mechanical properties were investigated. Results show that voids appear inside the stir zone when the small plunge depth of 0 mm is used because the tool shoulder cannot exert a good material-collecting effect at such low plunge depth. A plunge depth of 0.1 mm causes tight contact between the shoulder and the material and thus results in good material-collecting effect, which is helpful to eliminate the void. Sound joints are attained at a wide range of welding parameters when using the shoulder plunge depth of 0.1 mm. No crack is observed inside the bonding ligament. The joints own higher failure loads when the retreating side (RS) of the joint bares the main load during the lap shear tests. The shear failure load first increases and then decreases with increasing the rotating and welding speeds, and the maximum failure load of 6419 N is obtained at 600 rpm and 150 mm/min. The hardness of the joint presents a “W” morphology and the minimum hardness is obtained at the heat affected zone. The joints present tensile fracture and shear fracture when the advancing side and RS bare the main loads, respectively.
Simplified estimation of anisotropic non-homogeneous extinction coefficients in porous solids considering spherical and cylindrical pore networks
Authors: Ramirez-Cabrera Manuel A. , Valades-Pelayo Patricio J. 
Published: January 2021

Abstract
This manuscript presents a simplified analysis for estimating anisotropic, non-homogeneous extinction coefficients in porous solids as a function of the pore morphology and size distribution. The model contains two main simplifications: (1) the pore network consists of hollow interspersed spheres and cylinders, and (2) each surface exchanges radiation (through diffuse emission) only with itself and adjacent surfaces. The model yields photon flight length (PFL) probability distribution functions (PDFs), describing Beerian and non-Beerian anisotropic extinction processes. The method is three orders of magnitude faster than the Monte Carlo Ray Tracing Method (MCRT), yielding Root Mean Square Errors between 0 and 35% for the PFL–PDFs and 0–25% for the anisotropic extinction coefficients. Finally, this work presents a local geometric criterium determining whether the model applies to some given area of the porous solid, so it remains useful even when not applicable to the whole domain.