bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allogeneic Hematopoietic Stem Cell Transplantation, Especially Haploidentical, May Improve Long-Term Survival for Children with High-Risk T-Cell Acute Lymphoblastic Leukemia in First Complete Remission
Authors: Zhang Yong-zhan , Bai Lu , Huang Xiao-jun , Lu Ai-dong , Wang Yu , Wu Jun , Zhang Xiao-hui , Zuo Ying-xi , Xu Lan-ping , Jia Yue-ping , Cheng Yi-fei , Zhang Le-ping 
Published: May 2021

Abstract
Background: The role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for children with high-risk (HR) T- cell acute lymphoblastic leukemia (T-ALL) in first complete remission (CR1) is still under critical discussion. Moreover, relapse is still the main factor affecting survival. This study explored the effect of allo-HSCT (especially haploidentical HSCT (haplo-HSCT) ) on improving survival and reducing relapse for children with HR T-ALL in CR1 and the prognostic factors of childhood T-ALL in order to identify who could benefit from HSCT.Methods: Seventy-four newly diagnosed pediatric T-ALL patients were included in this study and stratified into low-risk chemotherapy cohort (n=16), high-risk chemotherapy cohort (n=31) and high-risk transplant cohort (n=27). The characteristics, survival outcomes and prognostic factors of all patients were analyzed.Results: Patient prognosis in the high-risk chemotherapy cohort was significantly inferior to the low-risk chemotherapy cohort (5-year overall survival (OS): 51.2%±10% vs. 100%, P = 0.003; 5-year event-free survival (EFS): 48.4%±9.8% vs. 93.8%±6.1%, P = 0.01; 5-year cumulative incidence of relapse (CIR): 45.5%±0.8% vs. 6.3%±0.4%, P = 0.043). For high-risk patients, allo-HSCT could improve the 5-year EFS and CIR compared to chemotherapy (5-year EFS: 77.0%±8.3% vs. 48.4%±9.8%, P = 0.041; 5-year CIR: 11.9%±0.4% vs. 45.5%±0.8%, P = 0.011). 5-year OS in high-risk transplant cohort had a trend for better than that in high-risk chemotherapy cohort ( 77.0%±8.3% vs. 51.2%±10%, P = 0.084). Haplo-HSCT could reduce relapse and had a trend for improving long-term survival for HR patients when compared to the high-risk chemotherapy cohort (5-year OS: 80.0%±8.9% vs. 51.2%±10%, P = 0.093; 5-year EFS: 80.0%±8.9% vs. 48.4%±9.8%, P = 0.047; 5-year CIR: 13.9%±0.6% vs. 45.5%±0.8%, P = 0.022). Minimal residual disease (MRD) re-emergence was the independent risk factor associated with 5-year OS, EFS and CIR.Conclusions: allo-HSCT, especially haplo-HSCT, might effectively improve the survival outcomes for HR childhood T-ALL in CR1.
New Hybrid Method Based Differential Evolution for Identifying a Single Diode Photovoltaic Cell Parameters with Temperature Variation
Authors: Mengue Martial Dieudonné , TEWA Alain KAMMOGNE SOUP , Yamapi René , Fotsin Hilaire Bertrand 
Published: May 2021

Abstract
At the time when renewable energy is making the headlines, photovoltaic technology has shown significant potential as one of the best energy sources. It is therefore necessary to predict the performance of a photovoltaic system by modeling it accurately and optimally. In this work, we propose a new hybrid algorithm for extracting parameters to improve the performance and the efficiency of a PV cell when subjected to temperature variations. The metaheuristic approach combined with an analytical approach to improve the accuracy and robustness that we call the Improved Differential Evolution (IDE). The performances of the proposed method are evaluated by clicking on cell data. For validation purposes, several analyses and comparisons are made with other methods, and the results illustrate the accuracy and precision of the IDE. The proposed technique is able to estimate the parameters in an optimal way whatever the temperature together with a high convergence speed and a short simulation time.
Effect of Home-based Prehabilitation in an Enhanced Recovery After Surgery Program for Patients Undergoing Colorectal Cancer Surgery during the COVID-19 Pandemic
Authors: -Arias Francisco López-Rodríguez , Sánchez-Guillén Luis , Aranaz-Ostáriz Verónica , Triguero-Cánovas Daniel , Lario-Pérez Sandra , Barber-Vallés Xavier , Lacueva Francisco Javier , Ramírez Jose M , Arroyo Antonio 
Published: May 2021

Abstract
BackgroundSurgery remains the first curative treatment for colorectal cancer. Prehabilitation seems to attenuate the loss of lean mass in the early postoperative period. However, its long-term role has not been studied. Lockdown due to COVID-19 pandemic has forced to carry out the prehabilitation program at home.This study aimed to assess the effect of home prehabilitation on body composition, complications and hospital stay in patients undergoing oncological colorectal surgery.MéthodsA prospective and randomized clinical study was conducted in 20 patients operated of colorectal cancer during COVID-19 lockdown (13th March -21st June 2020) in a single university clinical hospital. Patients was randomly into two study groups (10 per group): Prehabilitation vs Standard Care. Changes in lean mass and fat mass at 45 and 90 days after surgery was measured using multifrequency bioelectrical impedance analysis.ResultsPrehabilitation managed to reduce hospital stay (4.8 vs 7.2 days, p = 0.052) and postoperative complications (20% vs 50%, p = 0.16).45 days after surgery, the loss of lean mass decreased (1.7% vs 7.1%, p = 0.17). These differences in lean mass were attenuated at 90 days, however, the standard care group increased considerably their fat mass compared to the prehabilitation group (+ 8.72% vs -8.16%).ConclusionsHome prehabilitation has proven its effectiveness achieving an attenuation of lean mass loss in the early postoperative period and a lower gain in fat mass in the late postoperative period. In addition, it has managed to reduce hospital stay and postoperative complications.Registration numberThis article is part of an ongoing, randomized and controlled clinical trial approved by the Ethics Committee of our Hospital and registred in ClinicalTrials.gov in August 2018 with registration number NCT03618329.
Determinants of Influenza Vaccine Hesitancy among Pregnant Women in Europe: A Systematic Review
Authors: Adeyanju Gbadebo Collins , Engel Elena , Koch Laura , Ranzinger Tabea , Shahid Imtiaz Bin Mohammed , Head Micheal G. , Eitze Sarah , Betsch Cornelia 
Published: May 2021

Abstract
Background

Pregnant women are at high risk for severe influenza, but maternal influenza vaccination uptake in most World Health Organization (WHO) European Region countries remains low, despite the presence of widespread national recommendations. An influenza vaccination reduces influenza-associated morbidity and mortality in pregnancy, as well as provides newborns with protection in their first months. Potential determinants of vaccine hesitancy need to be identified to develop strategies that can increase vaccine acceptance and uptake among pregnant women. The primary objective of the systematic review is to identify the individual determinants of influenza vaccine hesitancy among pregnant women in Europe and how to overcome the hesitancy.
Methods

Databases were searched for peer-reviewed qualitative and quantitative studies published between 2009 and 2019. These included PubMed via MEDLINE, Cochrane Central Register for Controlled Trials, PsycINFO, SAGE Journals, Taylor & Francis and Springer nature, covering the areas of psychology, medicine, and public health. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) approach, 11 studies were eligible and analyzed for significant determinants of influenza vaccine hesitancy among pregnant women in Europe.
Results

The most reported factors were psychological aspects, for example concerns about safety and risks to mother and child, or general low risk perception of becoming ill from influenza. Doubts about the effectiveness of the vaccine and a lack of knowledge about this topic were further factors. There was also influence of contextual factors such as healthcare workers not providing adequate knowledge about the influenza vaccine or stating their anti-vaccine sentiment.
Conclusion

To overcome influenza vaccine hesitancy among pregnant women, it seems essential to increase the knowledge about influenza and the respective vaccination and to provide information for a valid risk judgment. The development of new information strategies for dialogue between healthcare providers and pregnant women should form part of this strategy.
Characterization of a major QTL and Genome-Wide Epistatic Interactions for the Transformation of Single Spikelet in Teosinte Ears into Paired Spikelets in Maize Ears During Maize Domestication
Authors: Chen Zhengjie , Hu Kun , Yin Yong , Tang Dengguo , Ni Jixing , Li Peng , Wang Le , Rong Tingzhao , liu jian 
Published: May 2021

Abstract
Maize ear carries paired spikelets, whereas the ear of its wild ancestor, teosinte, bears single spikelets. However, little is known about the genetic basis of the processes of transformation of single spikelets in teosinte ear to paired spikelets in maize ear. In this study, a two-ranked, paired-spikelets primitive maize and a two-ranked, single-spikelet teosinte were utilized to develop an F2 population, and QTL mapping for single vs. paired spikelets (PEDS) was performed. Two QTL (qPEDS1.1 and qPEDS3.1) for PEDS located on chromosomes 1L and 3S were identified in the 162 F2 plants using the inclusive composite interval mapping of additive (ICIM-ADD) module, explaining 1.93% and 23.79% of the phenotypic variance, respectively. Out of the 409 F2 plants, 43 plants with PEDS = 0% and 43 plants with PEDS > 20% were selected for selective genotyping; the QTL (qPEDS3.1) accounting for 64.01% of the phenotypic variance for PEDS was also detected. Moreover, the QTL (qPEDS3.1) was validated in three environments, which explained 31.05%, 38.94% and 23.16% of the phenotypic variance, respectively. In addition, 50 epistatic QTLs were detected in 162 F2 plants using the two-locus epistatic QTL (ICIM-EPI) module; they were distributed on all 10 chromosomes and explained 94.40% of the total phenotypic variance. The results contribute to a better understanding of the genetic basis of domestication of paired spikelets and provide a genetic resource for future map-based cloning; in addition, the systematic dissection of epistatic interactions underlies a theoretical framework for overcoming epistatic effects on QTL fine mapping.
Assessing The Economic Viability And Fueling Capacity of Renewable Hydrogen: A Way Forward For Green Economic Performance And Policy Measures
Authors: Wu Baijun , Zhai Bingfeng , Mu Huaizi , Peng Xin , Wang Chao , Patwary Ataul Karim 
Published: May 2021

Abstract
Energy security and environmental measurements are incomplete without renewable energy therefore there is a dire need to explore new energy sources. Therefore, the aim of this study is to measure the wind power potential to generate the renewable hydrogen including its production and supply cost. We used first order eneginnering model and net present value to measure the levelized cost of wind generated renewable hydrogen by using the data source of Pakistan metorological department and State bank of Paksitan. Results shows that the use of surplus wind and renewable hydoregn energy for green economic production is suggested as an innovative project option for large-scale hydrogen use. The key annual running expenses for hydrogen are electricity and storage cost, which have a major impact on the costs of renwable hydrogen. Also, the results indicates that project has the potential to cut CO2 pollution by 139 million metric tons and raise revenue for wind power plants by 2998.52 million dollars. The renewable electrolyzer plants avoided CO2 at a rate of 24.9–36.9 $/ton under baseload service, relative to 44.3 $/ton for the benchmark. However, in the more practical mid-load situation, these plants have a significant benefit. Further, the wind generated renewable hydrogen deliver a 6–11% larger than annual rate of return than the standard CO2 catch plant due to their capacity to remain running and supply hydrogen to the consumer through periods of plentiful wind and heat. Also, the measured levelized output cost of hydrogen (LCOH) was 6.22$/kgH2 and for the PEC system, it was 8.43 $/kgH2. Finally, its mutually agreed consensus of the environmental scientist that integration of renewable energy is the way forward to increase energy security and environmental performance by ensuring uninterrupted clean and green energy. Further, this application has the potential to address Pakistan’s urgent issues of large-scale surplus wind and solar-generated energy, as well as rising enegry demand.
Clinical Aspects and Prognostic Factors for Survival in Patients with Recurrent Cervical Cancer after Radical Hysterectomy and Adjuvant Radiochemotherapy
Authors: Zhu Huiting , Yan Wenjuan , Gao Yuhua 
Published: May 2021

Abstract
Purpose To investigate the recurrence patterns and prognostic factors of patients with recurrent cervical cancer after radical hysterectomy with node dissection (RHND) followed by adjuvant radiotherapy (RT)/concurrent radiochemotherapy (CCRT). Methods Between January 1, 2012 and May 31, 2018, the medical records of 153 patients with pre-operative FIGO stage IB-IIA disease treated with RHND followed by adjuvant RT/CCRT in Liaoning Cancer Hospital were retrospectively analyzed. Results The median disease progression-free survival (PFS) time was 16 months. 75.2% (115/153) patients had disease relapse within 2 years. The survival of patients with recurrences in multiple organs was signifificantly lower in comparison to those with recurrences in single organ ( P <0.001). The survival rate of patients with distant metastasis (DM) and distant metastasis with local recurrence (LR) was significantly lower than that of patients with simple LR ( P =0.006, P <0.001). Furthermore, the survival rate of patients with LR+DM was significantly lower than that of patients with simple DM ( P =0.046).The multivariate analysis showed that resection margin involvement, para-aortic and common iliac lymph node metastasis, DM, no treatment after disease relapse and early disease relapse were independent prognostic fators asscociated with poor survivals. Conclusion Most cervical cancer patients who received initial RHND followed by adjuvant RT/CCRT occurred disease relapse within 2 years. Resection margin involvement, para-aortic and common iliac lymph node metastasis, DM, no treatment after recurrence and early disease relapse were found to be prognostic factors in patients with recurrent cervical cancer after RHND followed by adjuvant RT/CCRT.
The Nomograms for Predicting Cancer-specific Survival in Patients With Ovarian Cancer After Surgery
Authors: Chen Xiaobin 
Published: May 2021

Abstract
Objectives: Clear cell adenocarcinoma of the ovary (CCAO) and mixed cell adenocarcinoma of the ovary (MACO) were one of the gynecological malignancies.Methods: Univariate and multivariate cox regression analysis were used to determine prognostic factors. Drawing nomograms, the receiver operating characteristic (ROC) curve and the calibration curve was applied to evaluate the agreement of the nomogram. The survival analysis was constructed to the high-risk factors.Results: The nomogram was constructed and had a better discrimination. The calibration curves indicated that the nomograms had good calibration capabilities.4 or more regional lymph nodes removed by surgery was beneficial to the patient's prognosis. Conclusions: Our study analyzed the prognosis of CCAO or MACO patients, and constructed a predictive nomogram with good accuracy.
Statistical Analysis of Mesovortices During The First Rainy Season In South China
Authors: Tang Ying , Xu Xin , Chen Yuanzhao , Chen Xunlai , Liang Jiahao , Liu Jia , Wang Yuan 
Published: May 2021

Abstract
Based on the Doppler radar observation and reanalysis data, the statistical characteristics of mesovortices (MVs) during the first rainy season (April–June) in South China from 2017 to 2019 are studied, including their spatio-temporal distributions, structural features and favorable environmental conditions. The results show that the MVs usually exhibit short lifetime, among which about 70% last for less than 30 minutes. The intensity and horizontal scale of the MVs are proportional to their lifetime. Long-lived MVs have larger horizontal scales and stronger intensities than short-lived ones. The MVs are mainly observed over the Pearl River Delta region, followed by the western Guangdong province, but relatively fewer in both eastern and northern Guangdong province. The uneven spatial distribution of the MVs is closely related to the differences of environment conditions over South China. The monsoonal south-westerlies, water vapor flux, atmospheric instability and vertical wind shear over southwest Guangdong are significantly larger than those in other regions, which are favorable for the formation of MVs. The occurrence frequencies of MVs in central and southern parts of Guangdong display similar diurnal variations, reaching the peak during the late afternoon and early evening, while dropping to the minimum overnight. However, the situation is opposite in northern Guangdong, with the peak overnight and the minimum during the late afternoon and early evening.
Portal and Mesenteric Venous Calcification in Patients with Advanced Cirrhosis: Two Case Reports and Literature
Authors: Pan Bing , Lyu Shao-Cheng , He Qiang 
Published: May 2021

Abstract
The incidence of portal and mesenteric venous calcifications in patients with cirrhosis has rarely been reported. It is also very difficult to determine the vascular lesions in preoperative imaging examination. The liver cirrhosis patients associated with portal venous calcification have high postoperative complications and mortality, but poor prognosis. We present the case of two patients (45-year-old male, case 1; 50-year-old male, case 2). Both patients were admitted to the hospital with liver cirrhosis and portal hypertension associated symptoms. The cases and review of published reports suggest that, calcification in the portal vein system is extremely rare, and always occurs in patients with long-standing liver cirrhosis with portal hypertension gastroesophageal varices and splenomegaly. The presence of portal vein calcification on CT may be a sign of portal vein thrombosis, which may result in a difficult transplantation, and poor prognosis.
Short-Pulse and Directional Thalamic Deep Brain Stimulation - Differential Effects in Parkinsonian and Essential Tremor
Authors: Hidding Ute , Schaper Miriam , Gulberti Alessandro , Buhmann Carsten , Gerloff Christian , Moll Christian , Hamel Wolfgang , Choe Chi-un , Pötter-Nerger Monika 
Published: May 2021

Abstract
The aim of this study was to assess the effects of novel stimulation algorithms of deep brain stimulation (short pulse and directional stimulation) in the ventrointermediate thalamus and posterior subthalamic area (VIM/PSA-DBS) on tremor in Parkinson´s disease (PD) and to compare the effects with those in Essential tremor (ET). Methods: We recruited six PD patients (70.8±10.4 years) and seven ET patients (64.4±9.9 years) with implanted VIM/PSA-DBS in a stable treatment condition (>3months postoperatively). Tremor severity and ataxia were assessed in four different stimulation conditions in a randomized order: DBS switched off (STIM OFF), omnidirectional stimulation with 60µs (oDBS60), omnidirectional stimulation with 30µs (oDBS30), directional stimulation at the best segment with 60µs (dDBS60)). Results: In both patient groups, all three DBS stimulation modes reduced the total tremor score compared to STIM OFF, whereas stimulation-induced ataxia was reduced by oDBS30 and partially by dDBS60 compared to oDBS60. Tremor reduction was more pronounced in PD than in ET due to a limited DBS effect on intention and action-specific drawing tremor. Conclusion: In PD and ET tremor, the use of short pulse or directional VIM/PSA-DBS is an effective tool to enhance the therapeutic window.The study was registered in the DRKS (ID DRKS00025329, 18.05.2021).
Efficacy of Insecticide Aerial Spraying Programs to Reduce Tree Mortality During a Spruce Budworm Outbreak (1967‒1992) in the Quebec Province.
Authors: Fuentealba Alvaro , Dupont Alain , Quezada-Garcia Roberto , Bauce Éric 
Published: May 2021

Abstract
Spruce budworm (Choristoneura fumiferana) is the most important pest of conifer forests in Eastern North America. The main approach to protect Quebec forests against this defoliator is aerial spraying of insecticides. Despite the crucial role of aerial spraying of insecticides in the global forest protection strategy, little is known about its real impact on tree mortality reduction or the stand characteristics that may affect its long-term efficacy. We evaluate the efficacy of the protection program implemented between 1967 and 1992 in reducing tree mortality during the previous outbreak in Quebec and how its efficacy is affected by stand characteristics such as drainage quality and stand age. We established 422 plots in Eastern Quebec based on the following parameters: insecticide application (0-13 years), stand composition, drainage quality, and stand age at the beginning of the previous outbreak. Our results show that unprotected plots exhibited in average between 18 and 32.6% higher mortality than protected plots. Insecticide efficacy was affected by drainage quality. For example, protected plots established on sites with bad drainage quality exhibited 49% less balsam fir mortality than unprotected plots. Furthermore, immature and mature protected stands exhibited a similar reduction in balsam fir mortality (32.2 and 32.1% less mortality respectively) compare to unprotected stands. Our results may be useful for decision-makers not only to decide where and when apply insecticides during a spruce budworm outbreak but also, they may help to determine the pertinence of continuous protection during longer than usual outbreaks depending on protection goal.