bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uniformization of branched surfaces and Higgs bundles
Authors: Biswas Indranil , Bradlow Steven , Dumitrescu Sorin , Heller Sebastian 
Published: September 2021

Given a compact connected Riemann surface [Formula: see text] of genus [Formula: see text], and an effective divisor [Formula: see text] on [Formula: see text] with [Formula: see text], there is a unique cone metric on [Formula: see text] of constant negative curvature [Formula: see text] such that the cone angle at each point [Formula: see text] is [Formula: see text] [R. C. McOwen, Point singularities and conformal metrics on Riemann surfaces, Proc. Amer. Math. Soc. 103 (1988) 222–224; M. Troyanov, Prescribing curvature on compact surfaces with conical singularities, Trans. Amer. Math. Soc. 324 (1991) 793–821]. We describe the Higgs bundle on [Formula: see text] corresponding to the uniformization associated to this conical metric. We also give a family of Higgs bundles on [Formula: see text] parametrized by a nonempty open subset of [Formula: see text] that correspond to conical metrics of the above type on moving Riemann surfaces. These are inspired by Hitchin’s results in [N. J. Hitchin, The self-duality equations on a Riemann surface, Proc. London Math. Soc. 55 (1987) 59–126] for the case [Formula: see text].
CICERO: A Domain-Specific Architecture for Efficient Regular Expression Matching
Authors: Parravicini Daniele , Conficconi Davide , Sozzo Emanuele Del , Pilato Christian , Santambrogio Marco D. 
Published: September 2021

Regular Expression (RE) matching is a computational kernel used in several applications. Since RE complexity and data volumes are steadily increasing, hardware acceleration is gaining attention also for this problem. Existing approaches have limited flexibility as they require a different implementation for each RE. On the other hand, it is complex to map efficient RE representations like non-deterministic finite-state automata onto software-programmable engines or parallel architectures. In this work, we present CICERO , an end-to-end framework composed of a domain-specific architecture and a companion compilation framework for RE matching. Our solution is suitable for many applications, such as genomics/proteomics and natural language processing. CICERO aims at exploiting the intrinsic parallelism of non-deterministic representations of the REs. CICERO can trade-off accelerators’ efficiency and processors’ flexibility thanks to its programmable architecture and the compilation framework. We implemented CICERO prototypes on embedded FPGA achieving up to 28.6× and 20.8× more energy efficiency than embedded and mainstream processors, respectively. Since it is a programmable architecture, it can be implemented as a custom ASIC that is orders of magnitude more energy-efficient than mainstream processors.
Diverse Oncogenic Fusions and Distinct Gene Expression Patterns Define the Genomic Landscape of Pediatric Papillary Thyroid Carcinoma
Authors: Stosic Ana , Fuligni Fabio , Anderson Nathaniel D. , Davidson Scott , de Borja Richard , Acker Meryl , Forte Vito , Campisi Paolo , Propst Evan J. , Wolter Nikolaus E. , Chami Rose , Mete Ozgur , Malkin David , Shlien Adam , Wasserman Jonathan D. 
Published: September 2021

AbstractPediatric papillary thyroid carcinoma (PPTC) is clinically distinct from adult-onset disease. Although there are higher rates of metastasis and recurrence in PPTC, prognosis remains highly favorable. Molecular characterization of PPTC has been lacking. Historically, only 40% to 50% of childhood papillary thyroid carcinoma (PTC) were known to be driven by genomic variants common to adult PTC; oncogenic drivers in the remainder were unknown. This contrasts with approximately 90% of adult PTC driven by a discrete number of variants. In this study, 52 PPTCs underwent candidate gene testing, followed in a subset by whole-exome and transcriptome sequencing. Within these samples, candidate gene testing identified variants in 31 (60%) tumors, while exome and transcriptome sequencing identified oncogenic variants in 19 of 21 (90%) remaining tumors. The latter were enriched for oncogenic fusions, with 11 nonrecurrent fusion transcripts, including two previously undescribed fusions, STRN-RET and TG-PBF. Most fusions were associated with 3′ receptor tyrosine kinase (RTK) moieties: RET, MET, ALK, and NTRK3. For advanced (distally metastatic) tumors, a driver variant was described in 91%. Gene expression analysis defined three clusters that demonstrated distinct expression of genes involved in thyroid differentiation and MAPK signaling. Among RET-CCDC6–driven tumors, gene expression in pediatric tumors was distinguishable from that in adults. Collectively, these results show that the genomic landscape of pediatric PTC is different from adult PTC. Moreover, they identify genomic drivers in 98% of PPTCs, predominantly oncogenic fusion transcripts involving RTKs, with a pronounced impact on gene expression. Notably, most advanced tumors were driven by a variant for which targeted systemic therapy exists.Significance:This study highlights important distinctions between the genomes and transcriptomes of pediatric and adult papillary thyroid carcinoma, with implications for understanding the biology, diagnosis, and treatment of advanced disease in children.
Megakaryocytes Mediate Hyperglycemia-Induced Tumor Metastasis
Authors: Wu Biying , Ye Ying , Xie Sisi , Li Yintao , Sun Xiaoting , Lv Mengyuan , Yang Ling , Cui Nan , Chen Qiying , Jensen Lasse D. , Cui Dongmei , Huang Guichun , Zuo Ji , Zhang Shaochong , Liu Wen , Yang Yunlong 
Published: September 2021

Abstract

High blood glucose has long been established as a risk factor for tumor metastasis, yet the molecular mechanisms underlying this association have not been elucidated. Here we describe that hyperglycemia promotes tumor metastasis via increased platelet activity. Administration of glucose, but not fructose, reprogrammed the metabolism of megakaryocytes to indirectly prime platelets into a prometastatic phenotype with increased adherence to tumor cells. In megakaryocytes, a glucose metabolism-related gene array identified the mitochondrial molecular chaperone glucose-regulated protein 75 (GRP75) as a trigger for platelet activation and aggregation by stimulating the Ca2+-PKCα pathway. Genetic depletion of Glut1 in megakaryocytes blocked MYC-induced GRP75 expression. Pharmacologic blockade of platelet GRP75 compromised tumor-induced platelet activation and reduced metastasis. Moreover, in a pilot clinical study, drinking a 5% glucose solution elevated platelet GRP75 expression and activated platelets in healthy volunteers. Platelets from these volunteers promoted tumor metastasis in a platelet-adoptive transfer mouse model. Together, under hyperglycemic conditions, MYC-induced upregulation of GRP75 in megakaryocytes increases platelet activation via the Ca2+-PKCα pathway to promote cancer metastasis, providing a potential new therapeutic target for preventing metastasis.

Significance:
This study provides mechanistic insights into a glucose–megakaryocyte–platelet axis that promotes metastasis and proposes an antimetastatic therapeutic approach by targeting the mitochondrial protein GRP75.
Vulnerability of IDH1-Mutant Cancers to Histone Deacetylase Inhibition via Orthogonal Suppression of DNA Repair
Authors: Dow Jonathan , Krysztofiak Adam , Liu Yanfeng , Colon-Rios Daniel A. , Rogers Faye A. , Glazer Peter M. 
Published: September 2021

Abstract

Exploitation of DNA repair defects has enabled major advances in treating specific cancers. Recent work discovered that the oncometabolite 2-hydroxyglutarate (2-HG), produced by neomorphic isocitrate dehydrogenase 1/2 (IDH1/2) mutations, confers a homology-directed repair (HDR) defect through 2-HG–induced histone hypermethylation masking HDR signaling. Here, we report that IDH1-mutant cancer cells are profoundly sensitive to the histone deacetylase inhibitor (HDACi) vorinostat, by further suppressing the residual HDR in 2-HG–producing cells. Vorinostat downregulates repair factors BRCA1 and RAD51 via disrupted E2F-factor regulation, causing increased DNA double-strand breaks, reduced DNA repair factor foci, and functional HDR deficiency even beyond 2-HG's effects. This results in greater cell death of IDH1-mutant cells and confers synergy with radiation and PARPi, both against cells in culture and patient-derived tumor xenografts. Our work identifies HDACi's utility against IDH1-mutant cancers, and presents IDH1/2 mutations as potential biomarkers to guide trials testing HDACi in gliomas and other malignancies.

Implications:
IDH1-mutant cells show profound vulnerability to HDACi treatment, alone and with PARPi and radiation, via HDR suppression, presenting IDH1/2 mutations as biomarkers for HDACi use in gliomas and other malignancies.
Real-time Colorized Video Images Optimization Method in Scotopic Vision
Authors: Yong Chen , Feng Shuai , Di Zhan 
Published: September 2021

<p><em>In low light environment, the surveillance video image has lower contrast</em><em>，</em><em>less information and uneven brightness. To solve this problem, this paper puts forward a contrast resolution compensation algorithm based on human visual perception model. It extracts Y component from the YUV video image acquired by camera originally to subtract contrast feature parameters, then makes a proportional integral type contrast resolution compensation for low light pixels in Y component and makes index contrast resolution compensation for high light pixels adaptively to enhance brightness of the video image while maintains the U and V components. Then it compresses the video images and transmits them via internet. Finally, it decodes and displays the video image on the device of intelligent surveillance system. The experimental results show that, the algorithm can effectively improve the contrast resolution of the video image and maintain the color of video image well. It also can meet the real-time requirement of video monitoring.</em><em></em></p>
A Novel Approach for Design and Analysis of Voltage-Controlled DSTATCOM for Power Quality Enhancement
Authors: Ruman Syed , Hameed Shaik 
Published: September 2021

The Power quality fluctuations of the distributed power system show a serious impact on the robust and sustainable operation of the distributed power system. These power quality fluctuations may be caused due to several reasons like leakage, faults and ageing of the lines. This project proposes a new algorithm to generate reference voltage for a controlled mode distribution static compensator (DSTATCOM) operating in voltage-control mode. The proposed scheme exhibits several advantages compared to traditional voltage-controlled DSTATCOM where the reference voltage is arbitrarily taken as 1.0 p.u. The proposed scheme ensures that unity power factor (UPF) is achieved, while regulating the voltage at the load terminal, during load change, which is not possible in the traditional method. Also, the compensator injects lower currents and, therefore, reduces losses in the feeder and voltage-source inverter. This scheme allows DSTATCOM to tackle power-quality issues by providing power factor correction, harmonic elimination, load balancing, and voltage regulation based on the load requirement. Simulation and experimental results are presented to demonstrate the efficacy of the proposed algorithm.
Providing Authentication by Using Biometric Multimodal Framework for Cloud Computing
Authors: Mala R. Parimala , Kumar C. Jayakumar 
Published: September 2021

Secret knowledge, like remembering password or token based authentication systems are deemed inconvenience and difficult to use for users such as password may be forgotten or token may be lost. So burdens like remembering password and stolen or forged token based authentication have raised a current trend of biometric authentication system. Now in this current tech world, everyone needs security everywhere to protect our personal gadgets. So to keep it secured, biometric based approach can be applied for better convenience and ease of use for the user. In this paper, a novel hybrid multimodal approach for ear recognition and finger print recognition has been presented for better robustness and efficiency which can be applied in various fields of applications like authentication in banking transactions. Biometric based human recognition is rapidly gaining popularity due to breached of traditional security systems and the lowering cost of sensors. This paper comprehensively reviews multimodal recognition using ear pattern and finger print data, it is concluded that further research should investigate fast and fully automatic ear-finger print multimodal systems robust to occlusions and deformations.
Transformerless high gain boost converter for low power applications with feedback control
Authors: Yaseen Md , Usha Dr. P 
Published: September 2021

A transformer-less boost converter which provides high voltage gain without utilizing transformer or coupled inductors and extreme duty cycle is proposed in this paper. Also it is able to cancel the ripples in the input current at a preselected duty cycle, without increasing the number of components. The converter combines the features of boost converter and a three switch high voltage converter. At the input side, two inductors are interleaved for cancelling the input current ripple and at the output side switched capacitor voltage multiplier is used to increase the voltage gain. Feedback control is used to make the output voltage constant in spite of variation in the input or load or both i.e. both line and load regulation is accompanied. This proposed converter configuration helps eliminate the input current ripple and provides voltage deregulation for low power applications.
Efficacy and Safety of Ticagrelor Monotherapy by Clinical Presentation: Pre‐Specified Analysis of the GLOBAL LEADERS Trial
Authors: Vranckx Pascal , Valgimigli Marco , Odutayo Ayodele , Serruys Patrick W. , Hamm Christian , Steg Philippe Gabriel , Heg Dik , Mc Fadden Eugene P. , Onuma Yoshinobu , Benit Edouard , Janssens Luc , Diletti Roberto , Ferrario Maurizio , Huber Kurt , Räber Lorenz , Windecker Stephan , Jüni Peter ,   the GLOBAL LEADERS Investigators
Published: September 2021

Background
The optimal duration of dual antiplatelet therapy after coronary drug‐eluting stent placement in adults with stable coronary artery disease (SCAD) versus acute coronary syndromes (ACS) remains uncertain.

Methods and Results

This was a prespecified subgroup analysis of the GLOBAL LEADERS trial. Participants were randomly assigned 1:1 to the experimental or reference strategy, stratified by ACS (experimental, n=3750; reference, n=3737) versus SCAD (experimental, n=4230; reference, n=4251). The experimental strategy was 75 to 100 mg aspirin daily plus 90 mg ticagrelor twice daily for 1 month, followed by 23 months of ticagrelor monotherapy. The reference strategy was 75 to 100 mg aspirin daily plus either 75 mg clopidogrel daily (for SCAD) or 90 mg ticagrelor twice daily (for ACS) for 12 months, followed by aspirin monotherapy for 12 months. The primary end point at 2 years was a composite of all‐cause mortality or non‐fatal centrally adjudicated new Q‐wave myocardial infarction. The key secondary safety end point was site‐reported Bleeding Academic Research Consortium grade 3 or 5 bleeding. The primary end point occurred in 147 (3.92%) versus 169 (4.52%) patients with ACS (rate ratio [RR], 0.86; 95% CI, 0.69–1.08;
P
=0.189), and in 157 (3.71%) versus 180 (4.23%) patients with SCAD (RR, 0.87; 95% CI, 0.71–1.08;
P
=0.221) with experimental and reference strategy, respectively (
P
‐interaction=0.926). Bleeding Academic Research Consortium grade 3 or 5 bleeding occurred in 73 (1.95%) versus 100 (2.68%) patients with ACS (RR, 0.73; 95% CI, 0.54–0.98;
P
=0.037), and in 90 (2.13%) versus 69 (1.62%) patients with SCAD (RR, 1.32; 95% CI, 0.97–1.81;
P
=0.081;
P
‐interaction=0.007).

Conclusions
While there was no evidence for differences in efficacy between treatment strategies by subgroup, the experimental strategy appeared to reduce bleeding risk in patients with ACS but not in patients with SCAD.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01813435.
Glutathione Infusion Before and 3 Days After Primary Angioplasty Blunts Ongoing NOX2‐Mediated Inflammatory Response
Authors: Tanzilli Gaetano , Arrivi Alessio , Placanica Attilio , Viceconte Nicola , Cammisotto Vittoria , Nocella Cristina , Barillà Francesco , Torromeo Concetta , Pucci Giacomo , Acconcia Maria Cristina , Granatelli Antonino , Basili Stefania , Dominici Marcello , Gaudio Carlo , Carnevale Roberto , Mangieri Enrico 
Published: September 2021

Background
Glutathione is a water‐soluble tripeptide with a potent oxidant scavenging activity. We hypothesized that glutathione administration immediately before and after primary angioplasty (primary percutaneous coronary intervention) could be effective in modulating immune cell activation, thereby preventing infarct expansion.

Methods and Results

One hundred consecutive patients with ST‐segment–elevation myocardial infarction, scheduled to undergo primary percutaneous coronary intervention were randomly assigned before the intervention to receive an infusion of glutathione (2500 mg/25 mL over 10 minutes), followed by drug administration at the same doses at 24, 48, and 72 hours elapsing time or placebo. Total leukocytes, NOX2 (nicotinamide adenine dinucleotide phosphate oxidase 2) activation, NO bioavailability, cTpT (serum cardiac troponin T), hsCRP (high‐sensitivity C‐reactive protein), and TNF‐α (tumor necrosis factor α) levels were measured. Left ventricular size and function were assessed within 120 minutes, 5 days, and 6 months from percutaneous coronary intervention. Following reperfusion, a significant reduction of neutrophil to lymphocyte ratio (
P
<0.0001), hsCRP generation (
P
<0.0001), NOX2 activation (
P
<0.0001), TNF‐α levels (
P
<0.001), and cTpT release (
P
<0.0001) were found in the glutathione group compared with placebo. In treated patients, blunted inflammatory response was linked to better left ventricular size and function at follow‐up (
r
=0.78,
P
<0.005).

Conclusions
Early and prolonged glutathione infusion seems able to protect vital myocardial components and endothelial cell function against harmful pro‐oxidant and inflammatory environments, thus preventing maladaptive cardiac repair and left ventricular adverse remodeling.

Registration

URL:
https://www.clinicaltrialsregister.eu
; Unique identifier: 2014‐004486‐25.
Risk Assessment of the Door‐In‐Door‐Out Process at Primary Stroke Centers for Patients With Acute Stroke Requiring Transfer to Comprehensive Stroke Centers
Authors: Holl Jane L. , Khorzad Rebeca , Zobel Rebecca , Barnard Amy , Hillman Maureen , Vargas Alejandro , Richards Christopher , Mendelson Scott , Prabhakaran Shyam 
Published: September 2021

Background
Patients with acute stroke at non‐ or primary stroke centers (PSCs) are transferred to comprehensive stroke centers for advanced treatments that reduce disability but experience significant delays in treatment and increased adjusted mortality. This study reports the results of a proactive, systematic, risk assessment of the door‐in‐door‐out process and its application to solution design.

Methods and Results
A learning collaborative (clinicians, patients, and caregivers) at 2 PSCs and 3 comprehensive stroke centers in Chicago, Illinois participated in a failure modes, effects, and criticality analysis to identify steps in the process; failures of each step, underlying causes; and to characterize each failure’s frequency, impact, and safeguards using standardized scores to calculate risk priority and criticality numbers for ranking. Targets for solution design were selected among the highest‐ranked failures. The failure modes, effects, and criticality analysis process map and risk table were completed during in‐person and virtual sessions. Failure to detect severe stroke/large‐vessel occlusion on arrival at the PSC is the highest‐ranked failure and can lead to a 45‐minute door‐in‐door‐out delay caused by failure to obtain a head computed tomography and computed tomography angiogram together. Lower risk failures include communication problems and delays within the PSC team and across the PSC comprehensive stroke center and paramedic teams. Seven solution prototypes were iteratively designed and address 4 of the 10 highest‐ranked failures.

Conclusions
The failure modes, effects, and criticality analysis identified and characterized previously unrecognized failures of the door‐in‐door‐out process. Use of a risk‐informed approach for solution design is novel for stroke and should mitigate or eliminate the failures.
Hizbullah’s ʿAshura Posters (2007–2020)
Authors: Hamdar Sarah 
Published: September 2021

Abstract
This article examines Hizbullah’s annual ʿAshura posters. It focuses on the campaigns created between 2007 and 2020 and places them against a backdrop of contemporary political events to demonstrate how the posters act as a significant site of political contestation and nationalist manifestation. By linking ʿAshura to contemporary politics in an ongoing reinterpretation of Imam Husayn’s martyrdom, Hizbullah places the Karbala battle at the center of its ideological identity, political actions and resistance activities, ultimately elevating its own fighters to Husayn’s position during Karbala. While Husayn is a figure mostly venerated within Shiʿa Islam, the article also demonstrates how Hizbullah utilizes the ʿAshura narrative to elevate Husayn—and ultimately the party’s fighters—to a transnational context by transforming the Karbala battle into a model for global resistance and victory. This is manifested in the posters’ meanings but also within the visual transformations whereby aesthetic changes reveal Hizbullah’s attempts at broadening its reach to a wider audience.
Abyssal Heat Budget in the Southwest Pacific Basin
Authors: Lele Ratnaksha , Purkey Sarah G. , Nash Jonathan D. , MacKinnon Jennifer A. , Thurnherr Andreas M. , Whalen Caitlin B. , Mecking Sabine , Voet Gunnar , Talley Lynne D. 
Published: September 2021

AbstractThe abyssal Southwest Pacific Basin has warmed significantly between 1992-2017, consistent with warming along the bottom limb of the meridional overturning circulation seen throughout the global oceans. Here we present a framework for assessing the abyssal heat budget that includes the time-dependent unsteady effects of decadal warming and direct and indirect estimates of diapycnal mixing from microscale temperature measurements and finescale parameterizations. The unsteady terms estimated from the decadalwarming rate are shown to be within a factor of 3 of the steady state terms in the abyssal heat budget for the coldest portion of the water column and therefore, cannot be ignored. We show that a reduction in the lateral heat flux for the coldest temperature classes compensated by an increase in warmer waters advected into the basin has important implications for the heat balance and diffusive heat fluxes in the basin. Finally, vertical diffusive heat fluxes are estimated in different ways: using the newly available CTD-mounted microscale temperature measurements, a finescale strain parameterization, and a vertical kinetic energy parameterization from data along the P06 transect along 32.5°S. The unsteady-state abyssal heat budget for the basin shows closure within error estimates, demonstrating that (i) unsteady terms have become consequential for the heat balance in the isotherms closest to the ocean bottom and (ii) direct and indirect estimates from full depth GO-SHIP hydrographic transects averaged over similarly large spatial and temporal scales can capture the basin-averaged abyssal mixing needed to close the deep overturning circulation.