bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Silico Studies, Synthesis and Biological Evaluation of 4,5-Dehydrospisulosine Butyrate Ceramides as Potential Sphingosine Kinase I Inhibitors
Authors: Kaur Parleen , Sharma Sonia , Randhawa Vinay , Agnihotri Navneet , Kaur Ramandeep , singh vasundhara 
Published: May 2021

Abstract
In the present work, synthesis of 4,5-dehydrospiulosine and its chain analogues (1-3) as potential Sphingosine Kinase I inhibitors has been achieved via the diasteroselective Grignard reaction, stereoselective cross metathesis reaction followed by N-acylation with p-nitrophenyl butyrate to give the corresponding butyrate ceramides (4-6). All compounds were obtained in high yield and purity followed by molecular docking simulation studies using AutoDock which indicated their varying binding affinities with Sphingosine Kinase 1 protein was done. Further, the biological evaluation studies, as potential anti-prostate cancer agents by inhibiting the sphingosine kinase 1 protien of all synthesized compounds (1-6) on PC-3 cell lines by SRB method was done. Compound N-((2S,3S,E)-3 hydroxyheptadec-4-en-2-yl) butyramide (4) exhibited remarkable cytotoxicity with an IC50 value of 6.06 µM.
A site-and-branch-heterogeneous model on an expanded dataset favor mitochondria as sister to known Alphaproteobacteria
Authors: Munoz-Gomez Sergio , Susko Edward , Williamson Kelsey , Eme Laura , Slamovits Claudio , Moreira David , Lopez-Garcia Purificacion , Roger Andrew 
Published: May 2021

Abstract
Determining the phylogenetic origin of mitochondria is key to understanding the ancestral mitochondrial symbiosis and its role in eukaryogenesis. However, the precise evolutionary relationship between mitochondria and their closest bacterial relatives remains hotly debated. The reasons include pervasive phylogenetic artefacts, as well as limited protein and taxon sampling. Here, we developed a new model of protein evolution that accommodates both across-site and across-branch compositional heterogeneity. We applied this site-and-branch-heterogeneous model (MAM60 + GFmix) to a considerably expanded dataset that comprises 108 mitochondrial proteins of alphaproteobacterial origin, and novel metagenome-assembled genomes from microbial mats, microbialites, and sediments. The MAM60 + GFmix model fits the data much better and agrees with analyses of compositionally homogenized datasets with conventional site-heterogenous models. The consilience of evidence thus suggests that mitochondria is sister to the Alphaproteobacteria to the exclusion of MarineProteo1 and Magnetococcia. We also show that the ancestral presence of a crista-developing MICOS complex (a Mitofilin domain-containing Mic60) supports this relationship.
Which of MIS-TLIF and TLIF Can Leads to Better Pedicle Screws Placement Accuracy and Clinical Outcomes with Navigation Guidance?
Authors: Liu JiaBin , Wu JunLong , Zuo Rui , Li ChangQing , Zhang Chao , Zhou Yue 
Published: May 2021

Abstract
Background Although previous studies have suggested that navigation can improve the accuracy of pedicle screw placement, there are still few studies comparing navigation-assisted transforaminal lumbar interbody fusion (TLIF) and navigation-assisted minimally-invasive TLIF (MIS-TLIF). The pedicle screw insertion entry point of navigation-assisted MIS-TLIF may be deflected from the planned entry point due to uneven bone-surface, which may result in misplacement. The purpose of this study was to explore the pedicle screws accuracy and clinical consequences of MIS-TLIF and TLIF both under O-arm navigation to determine which surgical method is better.MethodsA retrospective study of 54 patients who underwent single-segment navigation-assisted MIS-TLIF (NM-TLIF) or navigation-assisted TLIF (N-TLIF) was conducted. In addition to the patient's demographic characteristics, intraoperative indicators and complications, the ODI and VAS scores were recorded and analyzed preoperatively, at 1, 6, 12 months and at the final follow-up postoperatively. The clinical accuracy and absolute accuracy of pedicle screw placement was assessed by postoperative CT. Multifidus muscle injury were evaluated by T2-weighted MRI.ResultsCompared with N-TLIF, NM-TLIF was more advantageous in the incision length, intraoperative blood loss, drainage volume, time before ambulation, length of hospital stays, blood transfusion rate and analgesia rate (p<0.05). The ODI and VAS for low back pain scores were better than those of N-TLIF at 1 month and 6 months after surgery (p<0.05). There was no significant difference in the screw clinical qualitative accuracy (97.3% vs. 96.2%, p>0.05). The absolute quantitative accuracy results show that the axial translational error, sagittal translational error and sagittal angle error of NM-TLIF group are significantly greater than that in N-TLIF group (P<0.05). The mean T2-weighted signal intensity of multifidus muscle in the NM-TLIF group was significantly lower than that in the N-TLIF group (P<0.05)ConclusionsCompared with N-TLIF, NM-TLIF has more minimally invasive advantages, it does not yield a lower accuracy of screw placement and can achieve better symptom relief in the middle stage of postoperative recovery. However，more attention on real-time adjustment should be paid to pedicle insertion in NM-TLIF, rather than just following the entry point and trajectory of the intraoperative plan.
Real-world Concordance in Microsatellite Instability Status Between PCR-based Testing and Next-Generation Sequencing Assay for Solid Tumors
Authors: Shimozaki Keitaro , Hayashi Hideyuki , Horie Sara , Chida Akihiko , Tsugaru Kai , Togasaki Kazuhiro , Kawasaki Kenta , Aimono Eriko , Hirata Kenro , Hamamoto Yasuo , Nishihara Hiroshi , Kanai Takanori 
Published: May 2021

Abstract
Background: Various malignancies exhibit high microsatellite instability (MSI-H) or mismatch repair deficiency (dMMR). The MSI-IVD kit, which can detect MSI status using a polymerase chain reaction (PCR)-based method, was approved as the first tumor-agnostic companion diagnostic for pembrolizumab in patients with MSI-H solid tumors in Japan. Recently, next-generation sequencing (NGS), which can also detect MSI-H/dMMR, has been made clinically available. However, the real-world concordance in MSI-H/dMMR between the PCR-based testing and NGS is yet to be thoroughly investigated.Methods: A retrospective study was conducted to evaluate the utility of MSI testing using PCR-based testing and NGS assay in patients eligible for both MSI testing and any NGS platform. Co-primary endpoints included positive and negative predictive values of MSI-H/dMMR.Results: Between December 2018 and June 2020, 40 patients underwent both PCR-based MSI testing and NGS assay for MSI. Two patients with gastric neuroendocrine carcinoma and ovarian cancer were confirmed to have MSI-H/dMMR in both examinations. Among the 38 patients diagnosed as microsatellite stable by PCR-based testing, 2 (5.2%) with pancreatic cancer were diagnosed as MSI-H after NGS analyses. NGS had positive and negative predictive values of 100% (2/2) and 94.7% (36/38), respectively, for MSI-H, while the concordance between NGS and PCR-based testing was 94.9% (38/40).Conclusion: Similar to PCR-based MSI testing, NGS can be useful for evaluating MSI/MMR status in clinical practice and could be an important alternative method for detecting MSI-H/dMMR in the future.
Study On Polyethylene-Based Carbon Fibers Obtained by Sulfonation Under Hydrostatic Pressure
Authors: Eun Jong Hyun , Lee Joon Seok 
Published: May 2021

Abstract
Carbon fibers were prepared using polyethylene fibers. The draw ratio of the polyethylene fibers and the sulfonation mechanism were investigated under hydrostatic pressures of 1 and 5 bar. The influence of the melt flow index of polyethylene on the sulfonation reaction was studied. Carbon fibers were prepared through the sulfonation of linear low-density polyethylene (LLDPE) fibers possessing side chains with a high melt flow index. The polyethylene fibers, which exhibited thermoplastic properties and plastic behavior, were cross-linked through the sulfonation process. Their thermal properties and mechanical properties changed to thermoset properties and elastic behavior. Although sulfonation was performed under a hydrostatic pressure of 5 bar, it was difficult to convert the highly oriented polyethylene fibers because of their high crystallinity, but partially oriented polyethylene fibers could be converted to carbon fibers. Therefore, sulfonation was performed using partially oriented LLDPE fibers with a melt flow index of 20 at 130°C for 2.5 hours under a hydrostatic pressure of 5 bar. The resulting fibers were carbonized under the following conditions: 1000°C, 5°C/min, and five minutes. Carbon fibers with a tensile strength of 2.03 GPa, a tensile modulus of 143.63 GPa, and an elongation at break of 1.42% were prepared.
A Protolith Reconstruction Model (PRM) for Metabasalt: Quantitative Protolith and Mass Transfer Estimation Based on Machine-learning Approach
Authors: Matsuno Satoshi , Uno Masaoki , Okamoto Atsushi , Tsuchiya Noriyoshi 
Published: May 2021

Abstract
Mass transfer in rocks provides a direct record of fluid–rock interaction within the Earth, including metamorphism, metasomatism, and hydrothermal alteration. However, mass transfer analyses are usually limited to local reaction zones where the protoliths are evident in outcrops (1–100 m in scale), from which regional mass transfer can be only loosely constrained due to uncertainty in protolith compositions. In this study, we developed protolith reconstruction models (PRMs) for metabasalt based on a machine learning approach. We constructed PRMs through learning multi-element correlations among basalt compositional datasets, including mid-ocean ridge, ocean island, and island arc basalts. The PRMs were designed to estimate trace-element compositions from inputs of 2–9 selected trace elements, and basalt trace-element compositions (e.g., Rb, Ba, U, K, Pb, Sr, and rare earth elements) were estimated from only four inputs with a reproducibility of ~0.1 log10 units (i.e., ±25%). Using Th, Nb, Zr, and Ti, which are typically immobile during metamorphism, as input elements, the PRM was verified by applying it to seafloor altered basalt with known protoliths. When suitable immobile elements are incorporated, a PRM can yield unbiased and accurate mass transfer analysis of any metabasalt with unknown protolith.
Copper Immobilization on Fe3o4@Agar: An Efficient Superparamagnetic Nanocatalyst for Green Buchwald-Hartwig Cross-coupling Reaction of Primary and Secondary Amines With Aryl Iodide Derivatives
Authors: Hoseinzade Kimia , Mousavi-Mashhadi Seyed Ali , Shiri Ali 
Published: May 2021

Abstract
Immobility of copper on magnetic nanoparticles was performed using surface rectification of Fe3O4 with Agar. The magnetic Fe3O4@Agar-Cu nanocatalyst was prepared and entirely characterized by different analyses such as Fourier transform infrared (FT‐IR), X‐ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), vibrating sample magnetometry (VSM), energy dispersive X-ray (EDX), thermogravimetric (TGA), and inductively coupled plasma (ICP). The nanocatalyst was applied in C-N bond formation through the cross-coupling reaction of aryl halides with primary or secondary amines in water as a green medium known as the Buchwald-Hartwig reaction. The results of the Buchwald-Hartwig reaction by Fe3O4@Agar-Cu magnetic nanoparticles as catalyst demonstrate excellent activity and stability in water. Moreover, this catalyst can be recycled several times without considerable loss in its activity.
Current-Induced Crystallisation in Heusler Alloy Films for Memory Potentiation in Neuromorphic Computation
Authors: Frost William , Elphick Kelvin , Samiepour Marjan , Hirohata Atsufumi 
Published: May 2021

Abstract
The current information technology has been developed based on von Neumann type computation. In order to sustain the rate of development, it is essential to investigate alternative technologies. Among them, neuromorphic computation has been attracting intensive studies using the current complementary metal oxide semiconductor (CMOS) architecture and beyond in recent years to mimic the functionality and operation of a synapse in a brain. One of the promising synapses is stochastic operation of a magnetic tunnel junction (MTJ). However another important feature of a synapse, memory potentiation, has been overlooked to date. In this study, a giant magnetoresistive (GMR) junction consisting of a half-metallic Heusler alloy is used as an artificial synapse while still achieving a low resistance-area product for low power consumption. Here the Heusler alloy films are grown on a (110) surface to promote layer-by-layer growth to reduce their crystallisation energy, which is comparable with Joule heating induced by a controlled current introduction. The current-induced crystallisation leads to the reduction in the corresponding resistivity, which acts as memory potentiation for an artificial GMR synapse. This offers more realistic neuromorphic computation with higher efficiency.
2D Polymeric Network of Cu/Na, A Route for the Preparation Truncated Octahedral Catalyst Applicable in the WGS Reaction
Authors: Razmara Zohreh 
Published: May 2021

Abstract
A 2D heterometallic copper(II)–sodium(I) complex based on pyridine 2,6-dicarboxylato (dipic2-) formulated as [Cu(μ-dipic)2{Na2(µ-H2O)4}]n. 2nH2O (1) has been synthesized. Thermal stability of complex 1 was studied by thermo gravimetric analysis (TGA) and differential thermal analysis (DTA). Single-crystal X-ray diffraction (SC-XRD) analysis showed that the parallelepiped colorless crystal of complex 1 crystallizes in a monoclinic system with the space group P2/c . A highly dispersed truncated octahedral catalyst formulated as Cu-Na/Al2O3 (CNM) was prepared by thermal decomposition of complex 1. Besides, the reference catalyst of Cu-Na/Al2O3 (CNR) was prepared by impregnation conventional method. The catalysts were examined by FT-IR, powder X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET) surface area, and subjected to water-gas shift (WGS) reaction in the temperature range of 150-400 °C. The catalysts showed strong surface structure-activity dependence in WGS reaction. Improved catalytic performance during the water-gas shift reaction was observed for CNM compared to CNR due to its high dispersion, smaller particle size, and higher BET specific surface area.
Analysis of small molecules against the NMDA receptor: an insight from virtual screening and molecular dynamics simulation based findings
Authors: Sharma Garima , Shukla Rohit , Singh Tiratha Raj 
Published: May 2021

Abstract
Alzheimer’s disease (AD) is a chronic intensifying neurodegenerative disorder and accounts for three-fourths of dementia cases. To date, there is no effective treatment available which can completely cure AD. The available medications can slower AD progression and can provide symptomatic relaxation. The N-methyl-d-aspartate receptor (NMDAR) plays a paramount role in the survival of neurons and synaptic plasticity. Although, excessive function of NMDAR cause excitotoxicity. Due to this the cell death process activated resulting into neurodegeneration and promotes AD. Hence in this study, we have screened 98,072 natural compounds by using Smina and idock. After that 154 compounds were selected and ADMET is predicted by using the pkCSM web-based server. From the ADMET analysis, 18 compounds were chosen and employed for the re-docking studies by using Autodock Vina. Then from the docking result, we have selected top three complexes (NMDAR-ZINC4258884, NMDAR-ZINC8635472, and NMDAR-ZINC15675934) and employed them for the 100 ns MDS studies. Based on MDS result analysis we have concluded that NMDAR-ZINC4258884 and NMDAR-ZINC15675934 are the best stable complex and can function as a lead compound against the NMDAR. Although this is a theoretical study while we have shortlisted only two compounds out of 98072 compounds and proposed them to the scientific community worldwide for further experimental validations.
The effects of information content of cash flow statement, dividend payout ratio, economic value added and corporate social responsibility on stock trading volume
Authors: Oktavianingsih Dwi Luvira , Safkaur Otniel , Sesa Pascalina V. S. 
Published: May 2021

Purpose - This study aims to empirically test and analyze the influence of information content of cash flow statements, Dividend Payout Ratio (DPR), Economic Value Added (EVA) Corporate Social Responsibility (CSR) on the trading volume of empirical study stocks in manufacturing companies listed on the Indonesia Stock Exchange from 2014 to 2018. Method - The number of samples used in this study was 169 taken from financial report on idx. The analytical techniques used were multiple regressions in order to obtain a comprehensive picture of the relationship between variable and each other. This research used a quantitative approach with its research population of companies included in the manufacturing sector listed on the Indonesia Stock Exchange in 2014- 2018..Result - Based on the results of this study, investment cash flow and Dividend Payout Ratio (DPR) significantly influenced the trading volume of stocks. Meanwhile, operating cash flow, funding cash flow, Economic Value Added (EVA) and Corporate Social Responsibility (CSR) had no significant effect on stock trading volume.Implication - This research is suggested to improve development of trading volume in investor decision making for investment and for companys’ performance assessment.Originality - This research is the study that used content of cash flow resporting information, dividend payout ratio, economic value added, corporate social responsibility on stock trading volume.
Pengembangan Benih Unggul Semangka Citra Jingga Melalui Teknik Kastrasi dan Polinasi di Desa Depokrejo, Purworejo, Jawa Tengah
Authors: Sujadmiko Heri , Daryono Budi Setiadi , Hanini Hanifa , Supriyadi Supriyadi 
Published: May 2021

Semangka (Citrullus lanatus (Thunberg.) Matsum & Nakai) merupakan tanaman hortikultura yang termasuk dalam familia Cucurbitaceae. Buah ini memiliki keunggulan dalam hal efisiensi selama penanaman dan produktivitas buah yang dihasilkan. Desa Depokrejo, Ngombol, Purworejo, Jawa Tengah merupakan salah satu wilayah sentra budidaya semangka yang sangat potensial untuk dikembangkan. Saat ini masyarakat Desa Depokrejo masih bergantung terhadap produk benih impor dengan harga yang cukup mahal. Salah satu upaya untuk menekan biaya produksi akibat pembelian benih yaitu melalui penerapan pemuliaan tanaman dengan teknik kastrasi dan polinasi. Program ini bertujuan untuk memberikan edukasi mengenai teknik kastrasi dan polinasi semangka kepada masyarakat untuk medorong lahirnya benih lokal yang berkualitas. Metode yang digunakan yaitu penyuluhan mengenai teknik budidaya semangka, pelatihan teknik kastrasi, dan polinasi pada semangka serta pendampingan berkala selama pemeliharaan buah dan pemanenan. Hasil dari porgram ini adalah kelompok tani Desa Depokrejo secara umum telah memahami teknik budidaya semangka mulai dari persiapan media tanam, penanaman, perawatan hingga penanganan terhadap kondisi tanaman yang kurang baik. Saat ini masyarakat Desa Depokrejo telah mampu menghasilkan benih semangka Citra Jingga hasil kastrasi dan polinasi sebagai produk benih semangka baru yang dapat dipasarkan di industri pertanian.
Cambios de usos del suelo en la periferia del área metropolitana de Buenos Aires. Aportes para una teoría de la rent gap periurbana
Authors: Apaolaza Ricardo , Venturini Juan Pablo 
Published: May 2021

Desde mediados de la década del 1990 se observa una fuerte expansión de urbanizaciones cerradas en las periferias metropolitanas de Buenos Aires, que avanzan sobre áreas ambientalmente frágiles, como humedales y suelos deteriorados por actividades extractivas. El diferencial entre la renta real de estos suelos y la alta renta potencial vinculada al uso residencial para sectores de ingresos altos tiende a ser capturado como una ganancia extraordinaria, y representa por ende un fuerte estímulo para la (re)inversión de capital y el avance inmobiliario. A través de análisis satelital y geoestadístico, el presente trabajo problematiza algunas de estas dinámicas, valiéndose de la hipótesis de un ciclo de cambios secuenciados en el uso del suelo tendiente a conformar una brecha de renta periurbana (o peri rent gap), con lo que se traza un paralelismo con la conocida teoría de Neil Smith.
Space Maintainer Treatment In Premature Loss Deciduous Tooth
Authors: Pamungkas Rey Bintang , . Jeffrey 
Published: May 2021

Abstract.
Introduction: The deciduous tooth period is an important period in child development. Premature loss of deciduous teeth is defined as the loss of deciduous teeth before they approach the eruption of permanent teeth. The prevalance of premature loss offered in several studies obtained was between 4.3% and 42.6%. Method: An 10 years-old-boy accompanied by her mother came to RSGMP Unjani, complaints of lower right nack teeth missing because they have to extracted since 3 mouth ago. Tooth have been extracted because of caries. Result: Result of clinical examination was found premature loss teeth 75, 74, and 85. The space in Moyers analysis was +0.2 mm in region 3 and +0.1 mm in region 4. Patient was treated with a fungsional removable-space-maintainer on teeth 75, 74, and 85. Conclusion: The results of premature loss is excess space in the arch, so to prevent further occlusion abnormalities in child’s growth and development process, we need a special appliance that is used to protect the space due to premature loss of deciduous teeth.
Keywords: Premature loss, space maintainer, deciduous teeth
divergencia entre medios de comunicación y poesía: Ecuador y el escenario social de Octubre 2019
Authors: Yanez Sophia 
Published: May 2021

El presente ensayo tiene como objetivo el tratar el círculo vicioso de la violencia y el colonialismo generado por los medios tradicionales de comunicación, contraponiendo sus prácticas con los atajos del sentido y de la búsqueda por la que nos lleva la poesía. A través de la alusión a los acontecimientos producidos en el escenario del levantamiento que el pueblo ecuatoriano protagonizó en Octubre de 2019, se confronta las prácticas mediáticas tradicionales que ocurrieron durante ese escenario histórico, con la teoría literaria del poeta y académico Iván Carvajal y su concepción sobre la construcción de un “país secreto” en donde la poesía da la pauta para caminos atávicos ocultos que organizan la sociedad y el sentir desde la imagen y el poder de la metáfora. La autora menciona además, el legado y la herencia espiritual de algunos importantes poetas ecuatorianos.
Ikan teri Engraulis encrasicolus berpotensi sebagai pangan fungsional
Authors: Salma Wa Ode , Ruwiah Ruwiah , Muchtar Febriana , Mudjahidah Nabilah Hanum , Nurdin Karwika Dwi Saputri , Bastaman Muhammad Rahmat 
Published: May 2021

Anchovy Engraulis encrasicolus is a good prospect to be developed in the future, maybe it can be used for hyperlipidemia diet. This study, therefore, aims to measure and assess the content of EPA (eikosapentaenoat acid) and DHA (docosahexaenoic acid).from Anchovy Engraulis encrasicolus oil extract. The samples were obtained from the city of Kendari in Southeast Sulawesi, Indonesia. It was processed and manufactured at the Halu Oleo University in Pharmacy Laboratory. Furthermore, the extraction process utilized the Soxhlet method, while measuring and analyzing the content of EPA and DHA using UV/Vis Spectropometric. It was found that 25 mg of Anchovy Engraulis encrasicolus oil produced DHA levels of 145,5 mg/g (14,5%) and EPA levels of 97,15 mg/g (7,71%). Anchovy Engraulis encrasicolus is a potential for functional food used to provide protection against diseases associated with metabolic disorders and diet hyperlipidemia.