bluuebunny/crossref_metadata_2025_split huggingface dataset:
The (Calli)graphic Regimes of Contemporary Vietnamese Art
Authors: Corey Pamela N. 
Published: February 2025

Abstract
In 1990s Hanoi, Vietnam, many contemporary artists navigated the written form as crucial to the logic of the pictorial field. These included Vũ Dân Tân (1946-2009), Trương Tân (b. 1963), and Nguyễn Văn Cường (b. 1973), among others. I examine these artistic experiments as integral to what many have hailed as the emergence of contemporary art in Vietnam, linked to the early effects of globalization and the impetus to freely engage with questions of selfhood following over forty years of a socialist realist mandate. However, I also suggest the significance of site to these practices, in particular the postsocialist graphic regime of the urban environment, with its traces of historical inscriptions, influx of commercial signage, and ubiquitous public propaganda posters that continue to coat the surfaces of cities today. The artworks discussed in this essay drove new understandings of art, particularly in the use of line and text to situate artistic expression as part of but also apart from the urban surfaces and graphic materials on and in which such unorthodox actions were enacted. As such, the (calli)graphic regime marked a radical shift in perceptions of what could be art in 1990s Vietnam.
The Aesthetics of “Northern Remnants” in Video Art from China
Authors: Larson Ellen 
Published: February 2025

Abstract
Since around the turn of the 21st century, contemporary multimedia artists and filmmakers from China have employed the moving image as a tool to capture temporalities shaped by urban-industrial decline in northern China. A counterpoint to massive economic prosperity within the Pearl River Delta, fueled by investments in new technologies and globalizing industries since Deng Xiaoping-era reforms, northern manufacturing zones have witnessed the dismantling of labor-driven forms of socialized production. Throughout the north, once thriving factory complexes and surrounding locales have been reduced to a ghostly shell of their former selves. Artists Wang Bing (b. 1967), Wang Mowen (b. 1989), and Cao Fei (b. 1978) each reference ghosts of cultural memory through visual presentations of bygone monuments from China's mid-20th century socialist past. These artists' moving image practices also point to a broader regional phenomenon in which divestment in northern Chinese socialized industrial production has fostered the accumulation of “northern remnants,” aesthetically marked by rust, melancholy, and slowness.
My Beautiful Picture Book
Authors: Azeez Halik 
Published: February 2025

Abstract
The influx of tourism capital in its post-war years has seen the terraforming of Sri Lanka's natural, socio-political, and cultural landscapes. Among its many neo-Orientalist implications is the marginalization of traditional professions, transforming them into performative roles. Examples include stilt fishermen who now fish primarily to serve the tourist gaze. And the persistent invisibility of structural violence and the exoticization of indentured labor in the tea industry, a colonial remnant that continues to thrive. More recently foreign entrepreneurs, posing as tourists, have exploited Sri Lanka's economy by acquiring long-term property leases, thereby pricing out locals and fostering new forms of structural racism and exclusivity. Utilizing images sourced from popular Instagram hashtags related to Sri Lanka, this project examines how tourist photography commodifies and simplifies the rich complexities of the country's landscapes, people, and culture into exotic backdrops for the consumption of privileged global travelers.
Structural and linear/nonlinear optical properties of PVC/ZnFe2O4 nanocomposites for optoelectronic devices
Authors: Elbasiony A. M. , AbdElrahman Mohamed , Said Basmat Amal M. , Abdelhamied M. M. , Awed A. S. 
Published: February 2025

Herein, ZnFe2O4 nanoparticles (ZFO-NPs) were synthesized via the sol-gel method and doped into the PVC matrix by solution casting technique. This study aimed to examine the effects of PVC/ZnFe2O4 nanocomposites’ structural properties, dielectric constants, and linear/nonlinear optical characteristics at different concentrations of ZFO-NPs (0, 1, 2, and 3 wt.%). XRD pattern proved that the ZFO-NPs have a cubic crystal structure with a lattice constant of 8.5 Å and crystallite size of 39.97 nm. SEM image and EDX spectra were used to illustrate the surface morphology and elemental compositions of ZFO-NPs. The optical bandgap declined from 4.14 eV for the undoped-PVC to 4.05, 3.94, and 3.88 eV for PVC+1% ZFO, PVC+ 2% ZFO, and PVC+3% ZFO films, respectively. While Urbach’s energy (EU) rose from 0.82 eV to 1.77, 1.88, and 2.04 eV, respectively. It is found that the values of the free carrier increase after the introduction of the nano-ZFO from 2.61 × 1014 cm−3 for the undoped-PVC polymer to 4.15 × 1019, 5.78 × 1019, and 6.21 × 1019 for PVC+1% ZFO, PVC+ 2% ZFO, and PVC+3% ZFO, respectively. Furthermore, the optical mobility increases from 8.73 × 10−4 c.s.kg−1 to 2.26 c.s.kg−1. In contrast, the optical resistivity of the pristine PVC is 0.275, which decreases to 3.1 × 10−9, 4.78 × 10−10, and 2.72 × 10−9 c−2.s−1kg−1 for the PVC+1% ZFO, PVC+ 2% ZFO, and PVC+3% ZFO, respectively. Moreover, the effect of ZFO-NPs on the nonlinear properties of PVC/ZnFe2O4 nanocomposites was addressed. Finally, the linear and nonlinear optical characteristics of doped-PVC with ZnFe2O4 NPs make them suitable for electronic devices.
Comparison of first and third generation EGFR-TKIs for the treatment of advanced non-small cell lung cancer: A real-world study
Authors: Shah Maitri , Shah Kashvi , Dave Hetvi , Khadela Avinash , Desai Chirag , Shah Sanket , Shah Gaurang 
Published: February 2025

Background Worldwide, lung cancer stands as a leading cause of mortality, with EGFR-mutated metastatic non-small cell lung cancer (NSCLC) accounting for a large percentage of cases in the Indian population. Different generations of EGFR-tyrosine kinase inhibitors (TKIs) are available to treat EGFR-mutated NSCLC. The purpose of our research was to evaluate and compare the superiority of osimertinib over gefitinib/erlotinib in terms of clinical effectiveness and safety. Methods A retrospective observational cohort study was conducted at the Clinical Oncology Center in the Western region of India. Patients suffering from EGFR-mutated metastatic NSCLC were recruited for the study. The response of EGFR-TKIs was assessed using objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), and incidence of adverse events (AE). Results A total of 75 patients treated with EGFR TKIs were enrolled in the study. The ORR of osimertinib and gefitinib/erlotinib was 11.11% and 25.64% (p = 0.142) and DCR was found to be 69.44% and 82.05% (p = 0.28) respectively. Osimertinib and gefitinib/erlotinib had respective median PFS of 8.43 and 10.68 months. The incidence of AE of osimertinib and gefitinib/erlotinib was 1.94 and 2.49 respectively. Conclusion Osimertinib was not found to be superior over gefitinib/erlotinib based on clinical effectiveness. Though it showed a better safety profile, the cost of the treatment of osimertinib over gefitinib/erlotinib was not justifiable.
Atypical audio-visual neural synchrony and speech processing in early autism
Authors: Wang Xiaoyue , Bouton Sophie , Kojovic Nada , Giraud Anne-Lise , Schaer Marie 
Published: February 2025

Abstract

Background
Children with Autism Spectrum disorder (ASD) often exhibit communication difficulties that may stem from basic auditory temporal integration impairment but also be aggravated by an audio-visual integration deficit, resulting in a lack of interest in face-to-face communication. This study addresses whether speech processing anomalies in young autistic children (mean age 3.09-year-old) are associated with alterations of audio-visual temporal integration.

Methods
We used high-density electroencephalography (HD-EEG) and eye tracking to record brain activity and gaze patterns in 31 children with ASD (6 females) and 33 typically developing (TD) children (11 females), while they watched cartoon videos. Neural responses to temporal audio-visual stimuli were analyzed using Temporal Response Functions model and phase analyses for audiovisual temporal coordination.

Results
The reconstructability of speech signals from auditory responses was reduced in children with ASD compared to TD, but despite more restricted gaze patterns in ASD it was similar for visual responses in both groups. Speech reception was most strongly affected when visual speech information was also present, an interference that was not seen in TD children. These differences were associated with a broader phase angle distribution (exceeding pi/2) in the EEG theta range in children with ASD, signaling reduced reliability of audio-visual temporal alignment.

Conclusion
These findings show that speech processing anomalies in ASD do not stand alone and that they are associated already at a very early development stage with audio-visual imbalance with poor auditory response encoding and disrupted audio-visual temporal coordination.
Integrating ultrasound radiomics and clinicopathological features for machine learning-based survival prediction in patients with nonmetastatic triple-negative breast cancer
Authors: Wenwen  , Jiang Zekun , Liu Jingyan , Liu Dingbang , Li Yiyue , He Yushuang , Zhao Haina , Ma Lin , Zhu Yixin , Long Qiongxian , Gao Jun , Luo Honghao , Jiang Heng , Li Kang , Zhong Xiaorong , Peng Yulan 
Published: February 2025

Abstract

Objective
This study aimed to evaluate the predictive value of implementing machine learning models based on ultrasound radiomics and clinicopathological features in the survival analysis of triple-negative breast cancer (TNBC) patients.

Methods and materials
All patients, including retrospective cohort (training cohort, n = 306; internal validation cohort, n = 77) and prospective external validation cohort (n = 82), were diagnosed as locoregional TNBC and underwent pre-intervention sonographic evaluation in this multi-center study. A thorough chart review was conducted for each patient to collect clinicopathological and sonographic features, and ultrasound radiomics features were obtained by PyRadiomics. Deep learning algorithms were utilized to delineate ROIs on ultrasound images. Radiomics analysis pipeline modules were developed for analyzing features. Radiomic scores, clinical scores, and combined nomograms were analyzed to predict 2-year, 3-year, and 5-year overall survival (OS) and disease-free survival (DFS). Receiver operating characteristic (ROC) curves, calibration curves, and decision curves were used to evaluate the prediction performance.

Findings
Both clinical and radiomic scores showed good performance for overall survival and disease-free survival prediction in internal (median AUC of 0.82 and 0.72 respectively) and external validation (median AUC of 0.70 and 0.74 respectively). The combined nomograms had AUCs of 0.80–0.93 and 0.73–0.89 in the internal and external validation, which had best predictive performance in all tasks (p < 0.05), especially for 5-year OS (p < 0.01). For the overall evaluation of six tasks, combined models obtained better performance than clinical and radiomic scores [AUCs of 0.83 (0.73,0.93), 0.81 (0.72,0.93), and 0.70 (0.61,0.85) respectively].

Interpretation
The combined nomograms based on pre-intervention ultrasound radiomics and clinicopathological features demonstrated exemplary performance in survival analysis. The new models may allow us to non-invasively classify TNBC patients with various disease outcome.
Analytical method for simultaneous quantification of levodopa and carbidopa in the injectable oleogel formulation by HPLC
Authors: Nakmode Deepa D. , Youssef Souha H. , Das Soumyajit , Song Yunmei , Garg Sanjay 
Published: February 2025

Abstract
The developed method for simultaneous detection of levodopa and carbidopa was able to separate the peaks of the drug and sodium bisulfite in the in-vitro release samples and stability samples. Levodopa (LD), a pro-drug of dopamine, is used as the gold standard treatment for Parkinson’s disease. It is usually prescribed with carbidopa (CD) to prevent the conversion of levodopa to dopamine peripherally, thus reducing undesirable side effects. Both drugs are unstable at pH 7.4 beyond 24 h due to their oxidation, therefore 0.2% sodium bisulfite is added to the formulation as an antioxidant. The separation was performed by gradient elution using the Luna-C18 column (250 × 4.6 mm, 5 µm) at a flow rate of 1 ml/min. The mobile phase was composed of mobile phase A 30 mM potassium phosphate and acetonitrile (95:5, v/v) with 35 mM tetrabutylammonium hydrogen sulphate and mobile phase B containing 30 mM potassium phosphate and acetonitrile (50:50 v/v). Drug peaks were detected at 280 nm with retention times of 3.05 ± 0.001 min for LD and 3.64 ± 0.001 min for CD. The validation of the method according to US FDA guidelines and results were found to be within acceptable limits. The method was linear from 10–100 µg/ml (r2 = 0.999) and 10–100 µg/ml (r2 = 0.999) for LD and CD, respectively. The developed method was applied to studying the drug release from in-situ gel. The environmental impact of the developed method was evaluated using various greenness assessment tools.

Graphical abstract
A content analysis of the Orbeez® Gel Blaster injury challenge on TikTok
Authors: Schneider Hannah P. , Reedy Jamie M. , McAdams Rebecca J. , Swedler David I. , Manganello Jennifer A. , Roberts Kristin J. , Middelberg Leah K. , McKenzie Lara B. 
Published: February 2025

Abstract

Background
TikTok is one of the fastest-growing social media platforms. With 50 million active daily users in the United States, videos on TikTok have the opportunity to reach an exceptionally large audience. It is of concern that some of these videos may be harmful, especially if they encourage dangerous or risky behavior that can increase injury risk. This is common for social media challenges, where people are encouraged to participate in and record a task and then post it on social media. The “Orbeez Challenge” was a challenge that went viral in 2022 and encouraged viewers to shoot water beads with Gel Blaster guns at others. The purpose of this study was to describe content for the “Orbeez Challenge” on TikTok, informed by pathways of the Elaboration Likelihood Model (ELM).

Methods
This study conducted a content analysis of TikTok videos related to the Orbeez challenge identified between October 5–11, 2022. A codebook was created by using abductive code generation, driven by an inductive iterative review of a sample of videos not included in the final study sample, and deductive code development to collect elements of the ELM.

Results
There were 125 videos in the final sample. Collectively, these videos had over 255 million views. Most (70.0%) of the creators were laypersons. Text (n = 97; 77.6%) and music (n = 83; 66.4%) were frequently present in the videos. Individuals were primarily shooting (47.2%) or loading (25.6%) the Gel Blaster. Nearly half (46.3%) of the content creators had between 10,000 and 500,000 followers. Most videos (n = 109; 87.2%) did not depict any injury prevention precautions, but of the 15 videos (12.0%) that did show injury prevention precautions, 14 (93.3%) were for eye protection.

Conclusions
This study characterized the content of the TikTok videos associated with the viral “Orbeez Challenge” and showed that TikTok videos could be characterized with guidance from a health communication theory. Despite their increased injury risk, the videos had high engagement and were most frequently posted by laypersons. This research presents an opportunity for countering injury challenges on social media and can guide injury professionals in designing and improving virtual health education campaigns.
Interaction between clock genes, melatonin and cardiovascular outcomes from ICU patients
Authors: Jiménez-Pastor Jose M. , Morales-Cané Ignacio , Rodríguez-Cortés Francisco J. , López-Coleto Luna , Valverde-León Rocío , Arévalo-Buitrago Pedro , Medina-Valverde María J. , De la Fuente-Martos Carmen , Acuña-Castroviejo Darío , Meira e Cruz Miguel , Luque Raúl M. , Sarmento-Cabral André , López-Soto Pablo J. 
Published: February 2025

Abstract

Background
Circadian rhythms, driven by biological clocks, help organisms align their physiological functions with environmental changes, promoting homeostasis. The central clock in the suprachiasmatic nucleus coordinates peripheral clocks via neurohumoral feedback involving proteins like CLOCK, BMAL1, CRY 1/2, and PER 1–3. In the ICU, these circadian processes often face disruptions from constant lighting, noise, and irregular sleep–wake cycles, impairing sleep quality and worsening stress responses. These disruptions can lead to adverse clinical effects, including higher cardiovascular complication rates. This study examines how ICU stays affect circadian rhythm regulators and their association with cardiovascular outcomes.

Results
Significant differences were identified in melatonin levels and the expression of BMAL1, PER1, RORA, and NR1D1 between ICU stays of ≤7 days and >7 days. The APACHE-II severity scale influenced melatonin and the expression of CLOCK, PER2, CRY2, and RORA. Nonlinear relationships were observed between melatonin, clock genes, heart rate, and blood pressure (systolic and diastolic). In certain groups, molecular and physiological data showed correlations exceeding 90%.

Conclusions
These findings highlight a robust association between circadian disruption, as measured by melatonin and clock genes, and cardiovascular physiological rhythms in ICU patients.
Navigating advanced renal cell carcinoma in the era of artificial intelligence
Authors: Najem Elie J. , Shaikh Mohd Javed S. , Shinagare Atul B. , Krajewski Katherine M. 
Published: February 2025

Abstract

Background
Research has helped to better understand renal cell carcinoma and enhance management of patients with locally advanced and metastatic disease. More recently, artificial intelligence has emerged as a powerful tool in cancer research, particularly in oncologic imaging.

Body
Despite promising results of artificial intelligence in renal cell carcinoma research, most investigations have focused on localized disease, while relatively fewer studies have targeted advanced and metastatic disease. This paper summarizes major artificial intelligence advances focusing mostly on their potential clinical value from initial staging and identification of high-risk features to predicting response to treatment in advanced renal cell carcinoma, while addressing major limitations in the development of some models and highlighting new avenues for future research.

Conclusion
Artificial intelligence-enabled models have a great potential in improving clinical practice in the diagnosis and management of advanced renal cell carcinoma, particularly when developed from both clinicopathologic and radiologic data.
The outpatient experience questionnaire for child and adolescent mental health services: reliability and validity following a nationwide survey
Authors: Iversen Hilde Hestad , Haugum Mona , Bjertnaes Oyvind 
Published: February 2025

Abstract

Background
The main objective was to evaluate the psychometric properties of the OutPatient Experience Questionnaire for Child and Adolescent Mental Health Services (OPEQ-CAMHS) among patients aged 16 and above, with a secondary objective of developing a parsimonious set of items and a short version of the instrument for this age group.

Methods
A national pilot study was conducted with adolescents from outpatient CAMHS in Norway, testing a new digital, continuous measurement approach using a measurement instrument developed through a comprehensive methodological framework. The study assessed missing data, ceiling effects, factor structure, internal consistency, discriminant validity, and construct validity. A shorter version was derived from psychometric results.

Results
The pilot study included responses from 555 (46.3%) patients. Low proportions of missing or “not applicable” responses were found for 18 of the 20 items, and all items were below the ceiling-effect criterion. Two scales emerged: “structure and process”, and “outcome”, both meeting alpha criteria. Each individual item demonstrated a stronger correlation with its expected scale than with any of the other scales. Construct validity was confirmed through associations with relevant variables expected to be associated with patient-reported experiences, including self-reported current state and well-being. The results supported a six-item short version.

Conclusions
Psychometric testing confirmed data quality, internal consistency, and construct validity of OPEQ-CAMHS. The short version addresses respondent burden concerns and is now ready for broad implementation in Norwegian CAMHS and potentially in similar healthcare settings worldwide.
The Role of Antibiotic Therapy in the Management of Facial Fractures: A Systematic Review
Authors: Michalczyk Katarzyna , Sobolewska Dominika , Wirkijowska Małgorzata , Gajek-Flanczewska Wiktoria , Flanczewski Sebastian , Woźniak Paulina , Wietrzykowska Ewa , Śliwińska Martyna , Podraza Anna , Wójtowicz Katarzyna , Walczak Agata 
Published: February 2025

Purpose:The administration of prophylactic doses of antibiotics is a standard procedure in the treatment of maxillofacial fractures. Maxillofacial fractures occur most frequently, and antibiotic therapy is often overused before and after surgery. Despite numerous studies, there are still no clear-cut treatment regimens. The present study aimed to empirically evaluate this aspect.Materials and methods:The authors conducted an extensive review of articles available in PubMed, Google Scholar, UpToDate, Science Direct, and Cochrane databases. The keywords mandibular fractures, maxillary fractures, antibiotic prophylaxis, antibacterial agents, postoperative antibiotic prophylaxis, mandible fracture; antibiotics, open reduction, internal fixation. Studies published between 1970 and 2021 were included in the review.Results:Adding postoperative antibiotic prophylaxis to the standard preoperative and/or perioperative antibiotic regimens showed no significant reduction in the risk of surgical site infections. Similarly, no difference was observed in infection risk when the analysis focused specifically on mandibular fractures or procedures involving open surgical techniques. We should also take into account the patient's general diseases that increase the risk of infection. The situation in which prophylaxis unequivocally needs to be applied is the connection of the fracture gap with the oral cavity (open fractures) or sinuses.Conclusion:The evidence for prophylactic antibiotic use in maxillofacial fractures is weak and inconsistent, with no clear recommendations on type, dose, or duration. Each treatment should be individualized and tailored to the particular clinical case. Particular attention should be paid to the patient's medical condition, comorbidities, and the type and extent of the injury. Routine antibiotic therapy in patients belonging to the low-risk group carries negative consequences, such as the development of antibiotic-positivity.