bluuebunny/crossref_metadata_2025_split huggingface dataset:
C–H Bond Functionalization Using Pd- and Au-Supported Catalysts with Mechanistic Insights of the Active Species
Authors: Ishida Tamao , Tokunaga Makoto , Zhang Zhenzhong , Murayama Haruno , Yamamoto Eiji 
Published: March 2021

AbstractThe process of C–H functionalization has been extensively studied as a direct C–C bond-forming reaction with high atomic efficiency. Efforts have also been made on such reactions by using supported catalysts, which are superior in terms of catalyst separation from the reaction mixture and reusability. In this review, an overview of C–H functionalization reactions, especially those involving Pd- and Au-supported catalysts, is presented. In particular, we discuss reaction mechanisms, active species, leaching, reusability, etc.1	Introduction2	Types of Supported Metal Catalysts and Their Active Species3	Modes of C–H Bond Activation4	Oxidative C–H C–H Coupling of Aryl Compounds5	C–H C–H Coupling Where One Side Is Aromatic6	C–H Acylation of Aromatic Compounds and Related Reactions7	Conclusion
Brønsted Acid Catalyzed Cyclization of Inert N-Substituted Pyrroles to Benzo[f]pyrrolo[1,2-a][1,4]diazepines
Authors: Zhang Jinlong , Jiang Gaoxi , Gao Zeng , Qian Jinlong , Yang Huameng 
Published: March 2021

AbstractTwo approaches involving intramolecular and intermolecular cyclization, respectively, have been developed for the direct and practical construction of a series of important benzo[f]pyrrolo[1,2-a][1,4]azepines by using Brønsted acid catalysts. Upon catalysis by TsOH, the intramolecular dehydroxylation/ring closure of 3-hydroxy-2-[2-(1H-pyrrol-1-yl)benzyl]isoindolin-1-ones provided various racemic benzo[f]pyrrolo[1,2-a][1,4]azepines in high yields. Furthermore, enantioenriched benzo[f]pyrrolo[1,2-a][1,4]azepines were also obtained by chiral phosphoric acid catalyzed intermolecular addition of [2-(1H-pyrrol-1-yl)phenyl]methanamines to 2-formylbenzoates under mild conditions.
Visible-Light-Mediated Synthesis of Rutaecarpine Alkaloids through C–N Cross-Coupling Reaction
Authors: Wang Guixia , Kong Xiangfei , Chen Dong , Li Shiqing , Wang Jinhua , Gou Tiantian , Zhang Linfeng 
Published: March 2021

AbstractA visible-light-initiated cross-dehydrogenative-coupling amination is described, featuring metal- and photocatalyst-free, at room temperature, and using air as an oxidant. The reaction provides a facile approach for the synthesis of rutaecarpine and its derivatives. The substrates with electron-withdrawing groups give higher yields than those with electron-donating groups, but the substituent position has a negligible influence on the yield. Using binaphthyl-diyl hydrogen phosphate and dibenzyl phosphate as catalysts both deliver satisfying yields. This straightforward light-driven strategy might be applicable to the synthesis of quinazolinone derivatives.
Total Intravenous Anesthesia for Myocardial Protection and Preconditioning
Authors: Choudhury Minati 
Published: March 2021

AbstractPerioperative myocardial injury is common after any major surgical procedure even with best possible anesthesia and surgical management. Organ preservation during surgical procedure prevents morbidity and mortality. The effect of ischemic preconditioning on myocardial as well as other organ protection is well known. A variety of other agents also shown to have preconditioning thus protective effect on myocardium during anesthesia and surgery. The beneficial effect of volatile anesthetic preconditioning is well studied. However, the effect of intravenous anesthetic agents on this context is still way to go. This review is an attempt to look into the latest available research regarding the preconditioning and myocardial protective effect of intravenous anesthetic agents.
Community crime prevention in Portugal: an introduction to Local Safety Contracts
Authors: Amante Ana , Saraiva Miguel , Marques Teresa Sá 
Published: March 2021

AbstractFollowing the philosophy of other international programs as proximity policing or situational crime prevention, the Local Safety Contracts (CLS) have been an innovative strategy in Portugal, as they allow the sharing of accountabilities between the central and the local administration, in association with the police and the community. Nonetheless, little has been written in Portugal about such strategies, and nothing at all for the international scientific community. The aim of this paper is therefore to present the CLS, discussing their crime prevention stance and their impacts on local communities. First, the new preventive and multidisciplinary organizational model that is at the basis of CLS is discussed. Then a qualitative assessment of implementation is made through a set of interviews to relevant actors. Conclusions are drawn based on the experiences of municipalities, police and administration, contributing to the debate on community crime prevention, and enhancing the need for multidisciplinary, multilevel and place-specific approaches.
Amylostereum areolatum.
Authors:   USA, USDA-ARS
Published: March 2021

Abstract

A. areolatum is a basidiomycete that causes a white rot of a broad range of conifers. Its invasiveness arises from a symbiotic association with woodwasps of the genus Sirex. The species Sirexnoctilio is listed as "highly invasive" on the ISSG/IUCN website (ISSG, 2008) and is a Regulated Pest for the USA (APHIS, 2009a). The wasp and the fungus are native to Europe, North Africa and western Asia where their damage is considered secondary (Spradbery and Kirk, 1978). Introduced to areas of the Southern Hemisphere where exotic pine species are grown in plantations, these organisms have caused major losses. The insect invaded New Zealand by at least 1900, but did not cause serious concern until the 1940s (Talbot, 1977). It later spread to Tasmania and the southern parts of Australia and the wasp/fungus association was introduced into southern South America, beginning in Uruguay in 1980 (Ciesla, 2003). Invasion of South Africa occurred in 1994 (Tribe, 1995). Woodwasps are repeatedly detected in material imported to the USA, but were successfully excluded until 2004 (Wilson et al., 2009). The wasp and fungus were later found in nearby Canada (Ontario), although apparently due to a separate introduction (Bergeron et al., 2008; Wilson et al., 2009). Recent surveys found the wasp in four states of the USA (Evans-Goldner and Bunce, 2009) and 25 counties of Ontario in Canada (Shields, 2009). Schiff (2008) summarizes differences in complexity of the ecological situations in the Southern Hemisphere countries and North America that could affect spread and impact of the fungus and wasp.
Diarthrothrips coffeae (coffee thrips).
Authors: Bigger Mike 
Published: March 2021

Abstract

The eggs are reniform and inserted into a slit cut in the leaf. They are small but visible to the naked eye. There are two nymphal stages on the tree, the full grown nymph being about 1.1 mm long and pale yellow. The prepupal and pupal stages are passed in the leaf litter beneath the tree. The prepupa is also pale yellow and about 1 mm long. Although small numbers can be found at any time of year, large build up of population tends to be found at the end of the dry season in February and March. Notley (1936) found a close correlation between temperature and population increase, slight infestations occuring when the mean monthly temperature exceeded 18.3°C for 4 months and a severe infestation after 6 months. He could find no correlation with temperature or with relative humidity. The infestation ended after a marked drop in temperature. Shading of coffee and mulching have beneficial effects. The insect more typically infests coffee at lower altitudes. Since the general use of grass mulch around the coffee, serious attacks have become rare (Crowe, 2004).
Gibberella xylarioides (coffee wilt).
Authors: Flood Julie 
Published: March 2021

Abstract

Conidia and ascospores are spread by wind, rain and through human activities (harvesting, pruning etc.) (Jacques-Felix, 1954). The pathogen can penetrate through wounds so any agency causing wounds will aid the spread of the fungus. Krantz and Mogk (1973) noted that most dying and dead trees had been wounded during weeding. Insects may also spread the disease from tree to tree (Wrigley, 1988). Seed from infected berries may contain the pathogen and seedborne infection was considered to be the way in which the disease has spread in Zimbabwe (Wrigley, 1988) but there is some uncertainty as to the identification of the pathogen in Zimbabwe and Girma et al. (2001) reported that seeds did not transmit the pathogen in Ethiopia.
Agave sisalana (sisal hemp).
Authors: Rojas-Sandoval Julissa , Acevedo-Rodríguez Pedro 
Published: March 2021

Abstract

Tropical succulent perennial of 1.5-2 m height, with thick leaves in a basal rosette of elongated sword-shaped leaves from the base. Stems: Two to three years after transplanting, a 20 cm tall stem is formed, which will reach a height of about 1.2 m when flowering. White, fleshy stems develop from underground buds at the base of the plant, first growing sideways and then upwards to form new plants. These new plants are known as suckers (DAFF, 2015). Trunk: The plant base is a short trunk (30-150 cm), from the top of which the spirally arranged leaves grow (DAFF, 2015). The components of the dry weight of sisal fibre are approximately 55-65% α-cellulose, 11-18% hemicelluloses, 7-15% lignin, 1% pectin and 1-8% ash (Elzebroek and Wind, 2008). Leaves: Stiff, heavy, persistent leaves that are 0.6-1.2 m long, 10.2-20.3 cm wide, and 2.5-10.2 cm thick when mature. Leaves are spirally arranged around the trunk, greyish-green in colour and covered by a layer of wax. Leaves contain coarse, cream-coloured or pale-yellow fibres (3%) (DAFF, 2015). Young leaves may have small spines along their margins; they disappear when the plant matures. Leaves have a terminal, dark brown, rigid, very sharp spine, 2-3 cm long. The cross-section at the base of the leaf resembles a flattened triangle (Elzebroek and Wind, 2008). Inflorescences: A large panicle with flowers arranged on the terminal portion in dense clusters, sessile, 4-5 cm long. Perianths with 6 segments, 6 stamens, filaments longer than the perianth segment, 3-4 cm long anthers. Style exserted, stigma 3-lobed (EOL, 2018). It only flowers once at around 2 years. Before flowering, a flower stalk of 4.5-6.0 m develops from the growth point. The flower stalk subdivides to form branches that bear the flowers. The flowers do not produce seed, but form bulbils, which are used for reproduction. Bulbils are borne in the axils of the bracteoles of the inflorescence after flowering. Flowers are yellowish green, with reddish filaments. Roots: A. sisalana has a shallow, fibrous root system up to 60 cm deep. The 2-4 mm thick root arises from leaf scars at the base of the bole beneath the soil surface, and extends up to 5 m horizontally way from the mother plant, forming suckers. These can be used for propagation (DAFF, 2015). Sisal produces subterraneous rhizomes from buds in the axils of the lower leaves. Along the rhizomes there are buds that may grow into new plants, forming colonies. Most of the roots are concentrated in the upper 40 cm of the soil, where they spread horizontally up to 5 m. A number of roots grow deeper than 40 cm, which results in good anchorage (Elzebroek and Wind, 2008). Fruit: This species is monocarpic (i.e., dies after fruiting). Fruits are capsules up to 6 cm long, 2-2.5 cm diameter, stipitate and beaked. Capsules rarely formed, and seeds (if any) are probably not viable. Vegetative bulbils are commonly produced below the flowers in the axils of bracts (Weber, 2003; Acevedo-Rodriguez and Strong, 2005).
Thekopsora areolata (cherry spruce rust).
Authors:   USA, USDA-ARS
Published: March 2021

Abstract

T. areolata is a heteroecious rust fungus; an obligate parasite with stages of its life cycle on cones of Picea species and leaves of Prunus spp. Reported from Europe and Asia, the fungus is a Regulated Pest for the USA. It is absent from North America, where susceptible species are native or introduced, and Australia and New Zealand, where such species are introduced. Although usually not a major problem in its native range, this rust could be more damaging as an invasive in other temperate areas. Due to the fact that small amounts of infection may be overlooked, accidental introduction could occur through importation of infected cones carrying aeciospores. The one known introduction to North America involved a tree of Prunus sp. in a garden, from which there was no documented spread.
Report on 2020 Safe to Touch Consensus Conference on Hazardous Drug Surface Contamination
Authors: Gabay Michael , Johnson Philip , Fanikos John , Amerine Lindsey , Kienle Patricia , Olsen MiKaela , Roussel Christine , Moody Mary Lynn 
Published: March 2021

Abstract

Purpose
The 2020 Safe to Touch Consensus Conference on Hazardous Drug Surface Contamination was convened in order to gather subject matter experts in the field of hazardous drug (HD) handling to develop consensus statements regarding surface contamination monitoring for adoption by stakeholders in the drug supply chain, policy, and healthcare arenas.

Summary
The Safe to Touch conference convened virtually on September 22, 24, and 26, 2020. An expert panel of healthcare providers with experience in HD handling, monitoring, and research; pharmacy and nursing operations; and medication safety led the conference. An experienced audience of approximately 25 reaction panel members provided feedback to the panel via a preconference survey, during the conference, and at a postconference virtual town hall. Additionally, expert speakers presented on a range of issues, including the impact of HD surface contamination on health, current regulations and standards, surface contamination monitoring technologies, and variables impacting surface contamination testing.

Conclusion
At the end of the conference, the expert panel developed 11 consensus statements and corresponding recommendations that should be widely disseminated in order to educate individuals regarding the impact of HD surface contamination and increase the scope of HD surface contamination monitoring. Institutions involved in the handling of HDs should set short- and long-term goals for implementation of applicable consensus statements.
Semiparametric regression analysis of bivariate censored events in a family study of Alzheimer’s disease
Authors: Gao Fei , Zeng Donglin , Wang Yuanjia 
Published: March 2021

SummaryAssessing disease comorbidity patterns in families represents the first step in gene mapping for diseases and is central to the practice of precision medicine. One way to evaluate the relative contributions of genetic risk factor and environmental determinants of a complex trait (e.g., Alzheimer’s disease [AD]) and its comorbidities (e.g., cardiovascular diseases [CVD]) is through familial studies, where an initial cohort of subjects are recruited, genotyped for specific loci, and interviewed to provide extensive disease history in family members. Because of the retrospective nature of obtaining disease phenotypes in family members, the exact time of disease onset may not be available such that current status data or interval-censored data are observed. All existing methods for analyzing these family study data assume single event subject to right-censoring so are not applicable. In this article, we propose a semiparametric regression model for the family history data that assumes a family-specific random effect and individual random effects to account for the dependence due to shared environmental exposures and unobserved genetic relatedness, respectively. To incorporate multiple events, we jointly model the onset of the primary disease of interest and a secondary disease outcome that is subject to interval-censoring. We propose nonparametric maximum likelihood estimation and develop a stable Expectation-Maximization (EM) algorithm for computation. We establish the asymptotic properties of the resulting estimators and examine the performance of the proposed methods through simulation studies. Our application to a real world study reveals that the main contribution of comorbidity between AD and CVD is due to genetic factors instead of environmental factors.
The rareC9P167S risk variant for age-related macular degeneration increases polymerization of the terminal component of the complement cascade
Authors: McMahon O , Hallam T M , Patel S , Harris C L , Menny A , Zelek W M , Widjajahakim R , Java A , Cox T E , Tzoumas N , Steel D H W , Shuttleworth V G , Smith-Jackson K , Brocklebank V , Griffiths H , Cree A J , Atkinson J P , Lotery A J , Bubeck D , Morgan B P , Marchbank K J , Seddon J M , Kavanagh D 
Published: March 2021

AbstractAge-related macular degeneration (AMD) is a complex neurodegenerative eye disease with behavioral and genetic etiology and is the leading cause of irreversible vision loss among elderly Caucasians. Functionally significant genetic variants in the alternative pathway of complement have been strongly linked to disease. More recently, a rare variant in the terminal pathway of complement has been associated with increased risk, Complement component 9 (C9) P167S. To assess the functional consequence of this variant, C9 levels were measured in two independent cohorts of AMD patients. In both cohorts, it was demonstrated that the P167S variant was associated with low C9 plasma levels. Further analysis showed that patients with advanced AMD had elevated sC5b-9 compared to those with non-advanced AMD, although this was not associated with the P167S polymorphism. Electron microscopy of membrane attack complexes (MACs) generated using recombinantly produced wild type or P167S C9 demonstrated identical MAC ring structures. In functional assays, the P167S variant displayed a higher propensity to polymerize and a small increase in its ability to induce hemolysis of sheep erythrocytes when added to C9-depleted serum. The demonstration that this C9 P167S AMD risk polymorphism displays increased polymerization and functional activity provides a rationale for the gene therapy trials of sCD59 to inhibit the terminal pathway of complement in AMD that are underway.
PPARγ: The Central Mucus Barrier Coordinator in Ulcerative Colitis
Authors: Fang Jian , Wang Hui , Xue Zhe , Cheng Yinyin , Zhang Xiaohong 
Published: March 2021

AbstractUlcerative colitis (UC) is an idiopathic, long-term inflammatory disorder of the colon, characterized by a continuous remitting and relapsing course. The intestinal mucus barrier is the first line at the interface between the host and microbiota and acts to protect intestinal epithelial cells from invasion. Data from patients and animal studies have shown that an impaired mucus barrier is closely related to the severity of UC. Depletion of the mucus barrier is not just the strongest but is also the only independent risk factor predicting relapse in patients with UC. Peroxisome proliferator-activated receptor gamma (PPARγ), a nuclear transcription regulator, is involved in the regulation of inflammatory cytokine expression. It is also known to promote mucus secretion under pathological conditions to expel pathogenic bacteria or toxins. More important, PPARγ has been shown to affect host-microbiota interactions by modulating the energy metabolism of colonocytes and the oxygen availability of the intestinal microbiome. It is well known that gut microbiota homeostasis is essential for butyrate generation by the commensal bacteria to supply energy resources for colonocytes. Therefore, it can be speculated that PPARγ, as a central coordinator of the mucus barrier, may be a promising target for the development of effective agents to combat UC.
Posterior aortic plication for tracheal compression by aortic dilatation in infants with congenital heart disease
Authors: Ko Yoshihiro , Nomura Koji , Murayama Fumiaki , Isobe Sho 
Published: March 2021

Abstract
Two infants with congenital heart disease developed life-threatening airway obstruction due to progressive dilatation of the aorta. Both underwent posterior aortic plication with extracorporeal bypass (9 and 4 months of age). After surgery, the arterial diameter was adequately reduced with a smooth aortic route leading to a wide airway space. Both patients were weaned from the ventilator shortly after surgery and are currently asymptomatic.
Triennial reproduction symposium: L. E. Casida Award for Excellence in Graduate Education: mentoring graduate students in animal science
Authors: Wettemann Robert P 
Published: March 2021

Abstract
Graduate education in animal science prepares students to enhance the understanding of biology and to utilize this knowledge to increase animal productivity. The mentor is instrumental in the development of scientists and must be dedicated to success of students. The approach used to guide an inquisitive student into a productive researcher and educator is formulated from the experiences of the mentor. The training program that the mentor was exposed to, as well as experiences to identify activities that are successful, can result in a unique program to nurture and stimulate students. A dedication to a productive research program is essential for mentoring. Participation in research early in a graduate program is important and it helps students realize that their research can be innovative and exciting. Frequent meetings between students and mentors are essential and participation in data collection and analyses by the student and mentor are great teaching events. Students must have knowledge of the basic sciences and the discipline as well as their focused research area. A demanding and comprehensive graduate education is essential to expand the scientific development of the future generation of researchers and educators.
Factors Associated With Outcomes After Burn Care: A Retrospective Study in Eastern Democratic Republic of Congo
Authors: Murhula Gauthier Bahizire , Musole Patrick Bugeme , Kafupi Nama Bienfait , Tshibwid Florent A Zeng , Mayeri Garhalangwamuntu Daniel , Cikomola Fabrice Gulimwentuga , Pompermaier Laura 
Published: March 2021

AbstractIn low-income countries, the incidence of burns is high and severe burns are frequently managed at peripheral facilities. Outcome after burn care is poorly studied although it might help identify risk-group and improve treatment strategies. This study aimed to study factors associated with in-hospital outcomes in a burn cohort in the Democratic Republic of Congo. In this retrospective study, we included burn patients admitted to the surgical department at the Hôpital Provincial Général de Référence de Bukavu between January 2013 and December 2018. Differences between groups were tested using χ 2 test or Fisher's exact tests or Wilcoxon rank sum test, as appropriate. Multivariate logistic regression was used to analyze the effect of patients and of burn characteristics on in-hospital mortality, prolongated length of stay (=LOS ≥ 25 days), and occurrence of complications. The study population consisted of 100 patients, mainly young males with the rural origin, moderate-sized but deep burns. Of them, 46 developed complications, 12 died. Median LOS was 25 days (IQR: 15–42). In-hospital death was independently associated with Total Burn Surface Area percentage “TBSA%” (OR = 3.96; 95% CI = 1.67–9.40) and Full-thickness Burns (FTB) (10.68; 1.34–84.74); prolongated LOS with FTB (3.35; 1.07–10.49), and complication with rural origin (5.84; 1.51–22.53), TBSA% (3.96; 1.67–9.40), FTB (4.08; 1.19–14.00), and burns on multiple sites (4.38; 1.38–13.86). In-hospital death was associated with TBSA% and FTB, prolongated LOS with FTB, and complications with burns characteristics and rural origin of the patients. Additional studies are necessary to investigate the effect of provided burn care on outcomes.