bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tobacco retail availability and cigarette and e-cigarette use among youth and adults: a scoping review
Authors: Travis Nargiz , Levy David T , McDaniel Patricia A , Henriksen Lisa 
Published: July 2021

ObjectiveStates and localities are formulating strategies to reduce the widespread retail availability of tobacco products. Evidence of associations between retailer density/proximity and tobacco use outcomes can help inform those strategies. We conducted a scoping review on tobacco retail availability and cigarette/e-cigarette use in adults and youth, and considered variations in spatial units, measures of retailer exposure and outcomes across studies.MethodsA systematic search for studies examining the association between retailer density/proximity and youth and adult cigarette/e-cigarette use was conducted across MEDLINE (PubMed), Web of Science and Google Scholar through 27 August 2020 with no restrictions.ResultsThirty-five studies were included in our qualitative synthesis. While there were differences in neighbourhood definitions (eg, egocentric vs administrative), there is evidence for a positive association between higher retailer density in egocentric neighbourhoods around homes and current smoking in adults and adolescents. Administrative unit measures in some studies showed associations with adult current smoking, and adolescent lifetime and current smoking. Studies on tobacco outlet proximity to homes obtained mixed results. Density/proximity of tobacco outlets around schools showed no or inverse association with adolescent smoking, but suggests higher susceptibility to smoking. Evidence of an association between e-cigarette retail availability and e-cigarette use is limited due to a small number of studies.ConclusionThe current literature provides limited empirical evidence of the association between tobacco retailer availability and smoking or e-cigarette use. More research with uniform measures of environmental exposure to tobacco retailers is needed to allow for greater comparability between studies.
Impact of flavours, device, nicotine levels and price on adult e-cigarette users’ tobacco and nicotine product choices
Authors: Yang Yong , Lindblom Eric N. , Salloum Ramzi G. , Ward Kenneth D. 
Published: July 2021

IntroductionTo understand the impact of e-cigarette devices, flavours, nicotine levels and prices on adult e-cigarette users’ choices among closed-system and open-system e-cigarettes, cigarettes and heated tobacco products (HTPs).MethodsOnline discrete choice experiments were conducted among adult (≥18 years) e-cigarette users (n=2642) in August 2020. Conditional logit regressions were used to assess the relative impact of product attributes and the interactions between product attributes and user characteristics, with stratified analyses to examine differences by smoking status and primarily used e-cigarette device and flavour.ResultsOn average, participants preferred non-tobacco and non-menthol flavours most, preferred open-system over closed-system e-cigarettes and preferred regular nicotine level over low nicotine level. However, the preference varied by demographics, smoking status and the primarily used e-cigarette device and flavour. The differences in preference among products/devices were larger than the difference among flavours or nicotine levels. Participants who primarily used closed-system e-cigarettes exhibited similar preferences for closed-system and open-system e-cigarettes, but those who primarily used open-system e-cigarettes preferred much more open-system over closed-system e-cigarettes. HTP was the least preferred product, much lower than cigarettes in general, but participants living in states where IQOS is being sold had similar preferences to cigarettes and HTPs.ConclusionsPeople are unlikely to switch to another product/device because of the restriction of flavour or nicotine level. If non-tobacco and non-menthol flavours were banned from open-system e-cigarettes, users may switch to menthol flavour e-cigarettes. Intervention strategies should be tailored to specific groups.
Concurrent training remodels the subcutaneous adipose tissue extracellular matrix of people living with HIV: a non-randomized clinical trial
Authors: Silva B.F. , Barletta F. , Pedro R.E. , Batista M.L. , Hernandes L. , de Moraes S.M.F. , Peres S.B. 
Published: July 2021

Evaluate the effect of 12 wks of concurrent training (CT) in the extracellular matrix (ECM) of subcutaneous adipose tissue (SAT) in people living with HIV/AIDS (PLWHA). In the non-randomized clinical trial, 19 participants, 11 healthy (HIV–) and 18 PLWHA under the use of highly active antiretroviral therapy (HAART) for at least 1 year (HIV+). All participants engaged in a moderate-intensity CT program for 12 weeks, 3 times a week. Before and after CT, aerobic and strength performance were assessed, as well as anthropometric and biochemical blood profiles. In addition, SAT biopsies were performed for histologic and morphometric analyses. Statistical analysis was carried out with R Studio, using descriptive and inferential analysis, ANOVA test, and mixed-effect model (P < 0.05). HIV+ showed higher levels of very-low-density lipoproteins and triglycerides and lower levels of high-density lipoproteins at baseline than HIV– (P < 0.05). All groups showed improved aerobic and strength performances (P < 0.05). Both groups showed reduced adipocyte sizes after CT (P < 0.05). Lastly, HIV+ presented smaller adipocytes and higher elastic fiber deposition at baseline and decreased after training only in HIV+, similar to the HIV group. Thus, CT in PLWHA promoted a decrease in the size heterogeneity of adipocytes and elastic fiber deposition, remodeling the ECM, and improving the SAT fibrosis profile. Brazilian Clinical Trials Registry (ensaiosclinicos.gov.br – UTN: U1111-1214-3022).Novelty: Adipose tissue fibrosis is improved by training in people living with HIV. Concurrent training remodels adipose tissue extracellular matrix.
Compact objects by gravitational decoupling in f(R) gravity
Authors: Sharif M. , Aslam Mariyah 
Published: July 2021

AbstractThe objective of this paper is to discuss anisotropic solutions representing static spherical self-gravitating systems in f(R) theory. We employ the extended gravitational decoupling approach and transform temporal as well as radial metric potentials which decomposes the system of non-linear field equations into two arrays: one set corresponding to seed source and the other one involves additional source terms. The domain of the isotropic solution is extended in the background of f(R) Starobinsky model by employing the metric potentials of Krori–Barua spacetime. We determine two anisotropic solutions by employing some physical constraints on the extra source. The values of unknown constants are computed by matching the interior and exterior spacetimes. We inspect the physical viability, equilibrium and stability of the obtained solutions corresponding to the star Her X-I. It is observed that one of the two extensions satisfies all the necessary physical requirements for particular values of the decoupling parameter.
Three-dimensional exotic Newtonian supergravity theory with cosmological constant
Authors: Concha Patrick , Ravera Lucrezia , Rodríguez Evelyn 
Published: July 2021

AbstractWe present a supersymmetric extension of the exotic Newtonian Chern–Simons gravity theory in three spacetime dimensions. The underlying new non-relativistic superalgebra is obtained by expanding the $${\mathcal {N}}=2$$

N
=
2

AdS superalgebra and can be written as two copies of the enhanced Nappi–Witten algebra, one of which is augmented by supersymmetry. We show that the exotic Newtonian superalgebra allows to introduce a cosmological constant to the extended Newtonian supergravity. Interestingly, the obtained supergravity action contains the extended Newton–Hooke supergravity as a sub-case.
Global-Local Enhancement Network for NMF-Aware Sign Language Recognition
Authors: Hu Hezhen , Zhou Wengang , Pu Junfu , Li Houqiang 
Published: July 2021

Sign language recognition (SLR) is a challenging problem, involving complex manual features (i.e., hand gestures) and fine-grained non-manual features (NMFs) (i.e., facial expression, mouth shapes,
etc
.). Although manual features are dominant, non-manual features also play an important role in the expression of a sign word. Specifically, many sign words convey different meanings due to non-manual features, even though they share the same hand gestures. This ambiguity introduces great challenges in the recognition of sign words. To tackle the above issue, we propose a simple yet effective architecture called Global-Local Enhancement Network (GLE-Net), including two mutually promoted streams toward different crucial aspects of SLR. Of the two streams, one captures the global contextual relationship, while the other stream captures the discriminative fine-grained cues. Moreover, due to the lack of datasets explicitly focusing on this kind of feature, we introduce the first non-manual-feature-aware isolated Chinese sign language dataset (NMFs-CSL) with a total vocabulary size of 1,067 sign words in daily life. Extensive experiments on NMFs-CSL and SLR500 datasets demonstrate the effectiveness of our method.
RELAY Subgroup Analyses by EGFR Ex19del and Ex21L858R Mutations for Ramucirumab Plus Erlotinib in Metastatic Non–Small Cell Lung Cancer
Authors: Nakagawa Kazuhiko , Nadal Ernest , Garon Edward B. , Nishio Makoto , Seto Takashi , Yamamoto Nobuyuki , Park Keunchil , Shih Jin-Yuan , Paz-Ares Luis , Frimodt-Moller Bente , Zimmermann Annamaria H. , Wijayawardana Sameera , Visseren-Grul Carla , Reck Martin ,   for the RELAY study investigators
Published: July 2021

Abstract

Purpose:
In EGFR-mutated metastatic non–small cell lung cancer (NSCLC), outcomes from EGFR tyrosine kinase inhibitors have differed historically by mutation type present, with lower benefit reported in patients with ex21L858R versus ex19del mutations. We investigated if EGFR-activating mutation subtypes impact treatment outcomes in the phase III RELAY study. Associations between EGFR mutation type and preexisting co-occurring and treatment-emergent genetic alterations were also explored.

Patients and Methods:
Patients with metastatic NSCLC, an EGFR ex19del or ex21L858R mutation, and no central nervous system metastases were randomized (1:1) to erlotinib (150 mg/day) with either ramucirumab (10 mg/kg; RAM+ERL) or placebo (PBO+ERL), every 2 weeks, until RECIST v1.1–defined progression or unacceptable toxicity. The primary endpoint was progression-free survival (PFS). Secondary and exploratory endpoints included overall response rate (ORR), duration of response (DOR), PFS2, time-to-chemotherapy (TTCT), safety, and next-generation sequencing analyses.

Results:
Patients with ex19del and ex21L858R mutations had similar clinical characteristics and comutational profiles. One-year PFS rates for ex19del patients were 74% for RAM+ERL versus 54% for PBO+ERL; for ex21L858R rates were 70% (RAM+ERL) versus 47% (PBO+ERL). Similar treatment benefits (ORR, DOR, PFS2, and TTCT) were observed in RAM+ERL–treated patients with ex19del and ex21L858R. Baseline TP53 comutation was associated with superior outcomes for RAM+ERL in both ex19del and ex21L858R subgroups. EGFR T790M mutation rate at progression was similar between treatment arms and by mutation type.

Conclusions:
RAM+ERL provided significant clinical benefit for both EGFR ex19del and ex21L858R NSCLC, supporting this regimen as suitable for patients with either of these EGFR mutation types.
Ceralasertib (AZD6738), an Oral ATR Kinase Inhibitor, in Combination with Carboplatin in Patients with Advanced Solid Tumors: A Phase I Study
Authors: Yap Timothy A. , Krebs Matthew G. , Postel-Vinay Sophie , El-Khouiery Anthony , Soria Jean-Charles , Lopez Juanita , Berges Alienor , Cheung S.Y. Amy , Irurzun-Arana Itziar , Goldwin Andrew , Felicetti Brunella , Jones Gemma N. , Lau Alan , Frewer Paul , Pierce Andrew J. , Clack Glen , Stephens Christine , Smith Simon A. , Dean Emma , Hollingsworth Simon J. 
Published: July 2021

Abstract

Purpose:
This study reports the safety, tolerability, MTD, recommended phase II dose (RP2D), pharmacokinetic/pharmacodynamic profile, and preliminary antitumor activity of ceralasertib combined with carboplatin in patients with advanced solid tumors. It also examined exploratory predictive and pharmacodynamic biomarkers.

Patients and Methods:
Eligible patients (n = 36) received a fixed dose of carboplatin (AUC5) with escalating doses of ceralasertib (20 mg twice daily to 60 mg once daily) in 21-day cycles. Sequential and concurrent combination dosing schedules were assessed.

Results:
Two ceralasertib MTD dose schedules, 20 mg twice daily on days 4–13 and 40 mg once daily on days 1–2, were tolerated with carboplatin AUC5; the latter was declared the RP2D. The most common treatment-emergent adverse events (Common Terminology Criteria for Adverse Events grade ≥3) were anemia (39%), thrombocytopenia (36%), and neutropenia (25%). Dose-limiting toxicities of grade 4 thrombocytopenia (n = 2; including one grade 4 platelet count decreased) and a combination of grade 4 thrombocytopenia and grade 3 neutropenia occurred in 3 patients. Ceralasertib was quickly absorbed (tmax ∼1 hour), with a terminal plasma half-life of 8–11 hours. Upregulation of pRAD50, indicative of ataxia telangiectasia mutated (ATM) activation, was observed in tumor biopsies during ceralasertib treatment. Two patients with absent or low ATM or SLFN11 protein expression achieved confirmed RECIST v1.1 partial responses. Eighteen of 34 (53%) response-evaluable patients had RECIST v1.1 stable disease.

Conclusions:
The RP2D for ceralasertib plus carboplatin was established as ceralasertib 40 mg once daily on days 1–2 administered with carboplatin AUC5 every 3 weeks, with pharmacokinetic and pharmacodynamic studies confirming pharmacodynamic modulation and preliminary evidence of antitumor activity observed.
FDA Approval Summary: Osimertinib for Adjuvant Treatment of Surgically Resected Non–Small Cell Lung Cancer, a Collaborative Project Orbis Review
Authors: Koch Abigail L. , Vellanki Paz J. , Drezner Nicole , Li Xiaoxue , Mishra-Kalyani Pallavi S. , Shen Yuan Li , Xia Huiming , Li Yangbing , Liu Jiang , Zirkelbach Jeanne Fourie , Palazov Elitza , Gamarian Aleksandr , Choo Qiuyi , Girčys Arūnas , Rohr Ulrich-Peter , Fesenko Nataliya , Spillman Dianne , Pazdur Richard , Beaver Julia A. , Singh Harpreet 
Published: July 2021

Abstract
On December 18, 2020, the FDA approved osimertinib as adjuvant therapy in patients with non–small cell lung cancer (NSCLC) whose tumors have EGFR exon 19 deletions or exon 21 (L858R) mutations, as detected by an FDA-approved test. The approval was based on the ADAURA study, in which 682 patients with NSCLC were randomized to receive osimertinib (n = 339) or placebo (n = 343). Disease-free survival (DFS) in the overall population (stage IB–IIIA) was improved for patients who received osimertinib, with an HR of 0.20; 95% confidence interval (CI), 0.15–0.27; P &lt; 0.0001. Median DFS was not reached for the osimertinib arm compared with 27.5 months (95% CI, 22.0–35.0) for patients receiving placebo. Overall survival data were not mature at the time of the approval. This application was reviewed under FDA's Project Orbis, in collaboration with Australia Therapeutic Goods Administration, Brazil ANVISA, Health Canada, Singapore Health Sciences Authority, Switzerland Swissmedic, and the United Kingdom Medicines and Healthcare products Regulatory Agency. This is the first targeted therapy adjuvant approval for NSCLC and has practice-changing implications.
Writings of the Subsoil in the Contemporary Congolese Novel
Authors: Garnier Xavier 
Published: July 2021

Abstract
The expression “geological scandal,” used at the end of the nineteenth century by the Belgian geologist Jules Cornet to describe the mineral wealth of the eastern Congo, has become even more relevant today if we think of the misfortunes that affect the region. Global predation in this part of central Africa is naturally at the heart of the literary preoccupations of many Congolese writers, who invent narrative forms that are able to account for what is being played out beneath the earth’s surface, in the bowels of the earth. In this paper, I wish to highlight the literature of the mine that begins in the colonial era of the Congolese novel and develops considerably in contemporary times. Through the reading of a few major Congolese novels, this article analyzes how the Congo’s subsoil is the vector of globalization.
Bringing Microphysics to the Masses: The Blowing Snow Observations at the University of North Dakota: Education through Research (BLOWN-UNDER) Campaign
Authors: Kennedy Aaron , Scott Aaron , Loeb Nicole , Sczepanski Alec , Lucke Kaela , Marquis Jared , Waugh Sean 
Published: July 2021

Abstract
Harsh winters and hazards such as blizzards are synonymous with the northern Great Plains of the United States. Studying these events is difficult; the juxtaposition of cold temperatures and high winds makes microphysical observations of both blowing and falling snow challenging. Historically, these observations have been provided by costly hydrometeor imagers that have been deployed for field campaigns or at select observation sites. This has slowed the development and validation of microphysics parameterizations and remote sensing retrievals of various properties. If cheaper, more mobile instrumentation can be developed, this progress can be accelerated. Further, lowering price barriers can make deployment of instrumentation feasible for education and outreach purposes. The Blowing Snow Observations at the University of North Dakota: Education through Research (BLOWN-UNDER) Campaign took place during the winter of 2019/20 to investigate strategies for obtaining microphysical measurements in the harsh North Dakota winter. Student led, the project blended education, outreach, and scientific objectives. While a variety of in situ and remote sensing instruments were deployed for the campaign, the most novel aspect of the project was the development and deployment of OSCRE, the Open Snowflake Camera for Research and Education. Images from this instrument were combined with winter weather educational modules to describe properties of snow to the public, K–12 students, and members of indigenous communities through a tribal outreach program. Along with an educational deployment of a Doppler on Wheels mobile radar, nearly 1,000 individuals were reached during the project.
Is There Interdecadal Variation in the South Asian High?
Authors: Zhang Dapeng , Huang Yanyan , Zhou BoTao , Wang Huijun 
Published: July 2021

AbstractThe decadal intensification of the South Asian high (SAH) after the late 1970s, which is determined based on the geopotential height (H), is suspicious due to the lifting effect upon H caused by global warming. The updated reanalysis datasets ERA5 and JRA-55 indicate that the anticyclone in the upper troposphere over the Tibetan Plateau is relatively weak during 1980–2018 compared to that during 1950–79. This decadal weakening of the SAH after 1979 can also be observed in the radiosonde observation data. Correspondingly, the SAH defined by eddy geopotential height (H′) reflects a consistent decadal weakening variation. The decadal weakening of SAH detected from H′ after the late 1970s matches with a decadal southward shift of the East Asian westerly jet, causing ascending motions over the Yangtze River valley and descending motions over North China. Moreover, the decadal weakening and westward shift of the SAH is accompanied with positive relative vorticity anomalies over the northwest Pacific in the upper troposphere, which implies a declining and eastward shift of the western Pacific subtropical high (WPSH) and a weakened East Asian summer monsoon (EASM). Hence, the decadal weakening of the SAH after the late 1970s may contribute to the Yangtze River flooding/North China drought pattern through its connection with other circulation systems of EASM.
Spectrum of Near-Storm Environments for Significant Severe Right-Moving Supercells in the Contiguous United States
Authors: Warren Robert A. , Richter Harald , Thompson Richard L. 
Published: July 2021

AbstractProximity soundings have long been used to explore how the vertical structure of temperature, humidity, and winds influence convective storms and their associated hazards. In severe thunderstorm research and forecasting, convective parameters are often used to summarize certain characteristics of the sounding. While extremely useful, these parameters are unable to describe the rich complexity that is readily apparent in hodographs and skew T–logp diagrams. Motivated by a desire to retain more of these details, the present study uses self-organizing maps (SOMs) to group soundings based on their full vertical structure. The analysis makes use of a sample of more than 10 000 model proximity soundings for right-moving supercells associated with tornadoes and significant severe hail and straight-line winds in the contiguous United States (CONUS). Separate SOMs are developed for the wind and thermodynamic profiles, each with 3 × 3 nodes, resulting in a set of nine hodographs and nine skew T–logp diagrams that broadly represent the spectrum of near-storm environments for significant severe right-moving supercells in the CONUS. Both SOMs are shown to provide a good representation of the variability in key convective parameters, although, for the thermodynamic SOM, variations in LCL heights and midlevel lapse rates are somewhat limited. Based on the soundings assigned to them, the SOM nodes are characterized in terms of their associated hazards, their relationship with storm mode and mesocyclone strength, and their spatial and temporal variability. Potential applications of the SOMs in severe weather forecasting and idealized numerical simulations are also highlighted.
Location, Location, Location? School District, Length of Residence and Attitudes Toward Diversity and Neighborhood Schools in the Upper South
Authors: Alexander Alyssa J. , Parcel Toby L. 
Published: July 2021

Attitudes toward diversity and neighborhood schools matter because they underlie many families’ decisions for residential location, with consequences for both school systems and students. Case studies of desegregation highlight locational dynamics that influence these outcomes, but differences in theory and methods limit rigorous comparisons among residents across such areas. This study focuses on two under-researched correlates of these preferences toward school assignment models: school district location and length of residence in that district. We evaluate whether school district location and length of residence decrease support for diverse schools and increase support for neighborhood schools, net of numerous controls. We use an innovative new dataset that features opinion polling of respondents’ views of public school assignments in Raleigh, NC; Charlotte, NC; Louisville, KY; Rock Hill, SC; and Nashville, TN (5302 cases). We find that compared to having lived in a school district 7 years or less, living in that district over 15 years decreases support for diversity. Furthermore, living all one’s life in a district increases support for neighborhood schools. We also find that Charlotte-Mecklenburg, Rock Hill, and Nashville districts are less supportive of neighborhood schools than Raleigh, but that there are also interactive effects between length of residence and school district location. These results shed light on district differences in social forces leading to school resegregation.