bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Rotigotine Transdermal Patch on Neuropsychiatric Symptoms of Parkinson's Disease: An Updated Meta-Analysis and Systematic Review
Authors: Yan Junqiang , Ma Hongxia , Liu Anran , Huang Jiarui , Wu Jiannan , Yang Jianxue 
Published: October 2021

Objective: The effects of rotigotine transdermal patch (RTG) on the neuropsychiatric symptoms of Parkinson's disease (PD) outcomes remain controversial. The aim of this review was to determine the efficacy and safety of RTG on the neuropsychiatric symptoms of PD.Methods: In this systematic review and meta-analysis, PubMed, Cochrane Library, EMBASE, and Web of Science were searched for randomized controlled trials comparing RTG and placebo in PD up to May 10, 2021. We analyzed the data using Review Manager 5.2 software. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation Approach. In order to avoid false-positive results caused by random error, we use TSA software for trial sequential analysis (TSA).Results: We included 10 studies (1,844 patients). The meta-analysis showed that, compared with placebo, RTG can significantly improve the scores for Apathy Scale (MD = −1.68, 95% confidence interval, CI: −2.74 to −0.62, P = 0.002; moderate certainty), Beck Depression Inventory-II (MD = −1.19, 95% CI: −2.26 to −0.11, P = 0.03; moderate certainty), the Non-Motor Symptoms Scale (MD = −3. 66, 95% CI: −4. 30 to −3.01, P &lt; 0.00001; moderate certainty), the sleep/fatigue domains of the Parkinson's Disease Non-motor Symptom Assessment Scale (MD = −2.03, 95% CI: −3.08 to −0.98, P = 0.0001; moderate certainty), the mood/apathy domains of the Non-motor Symptom Scale (MD = −2.48, 95% CI: −4.07 to −0.89, P = 0.002; high certainty), the eight-item Parkinson's Disease Questionnaire (MD = −4. 93, 95% CI: −6.79 to −3.07, P &lt; 0.00001; moderate certainty), and the 39-item Parkinson's Disease Questionnaire (MD = −3.52, 95% CI: −5.25 to −1.79, P &lt; 0.0001; high certainty). However, there was no statistically significant difference on the Snaith–Hamilton Pleasure Scale (MD = −0.12, 95% CI: −0.58 to 0.34, P = 0.61). Our results showed that RTG exerts a positive effect on sleep. According to the TSA, the results implied that, except for the Beck Depression Inventory-II, conclusive evidence have been obtained in the RTG group. It has been proven in our meta-analysis that rotigotine has good safety and tolerability.Conclusions: RTG can effectively improve the neuropsychiatric symptoms, sleep quality, and quality of life in patients with PD.
Involvement of ADGRV1 Gene in Familial Forms of Genetic Generalized Epilepsy
Authors: Dahawi Maha , Elmagzoub Mohamed S. , A. Ahmed Elhami , Baldassari Sara , Achaz Guillaume , Elmugadam Fatima A. , Abdelgadir Wasma A. , Baulac Stéphanie , Buratti Julien , Abdalla Omer , Gamil Sahar , Alzubeir Maha , Abubaker Rayan , Noé Eric , Elsayed Liena , Ahmed Ammar E. , Leguern Eric 
Published: October 2021

Background: Genetic generalized epilepsies (GGE) including childhood absence epilepsy (CAE), juvenile absence epilepsy (JAE), juvenile myoclonic epilepsy (JME), and GGE with tonic–clonic seizures alone (GGE-TCS), are common types of epilepsy mostly determined by a polygenic mode of inheritance. Recent studies showed that susceptibility genes for GGE are numerous, and their variants rare, challenging their identification. In this study, we aimed to assess GGE genetic etiology in a Sudanese population.Methods: We performed whole-exome sequencing (WES) on DNA of 40 patients from 20 Sudanese families with GGE searching for candidate susceptibility variants, which were prioritized by CADD software and functional features of the corresponding gene. We assessed their segregation in 138 individuals and performed genotype–phenotype correlations.Results: In a family including three sibs with GGE-TCS, we identified a rare missense variant in ADGRV1 encoding an adhesion G protein-coupled receptor V1, which was already involved in the autosomal recessive Usher type C syndrome. In addition, five other ADGRV1 rare missense variants were identified in four additional families and absent from 119 Sudanese controls. In one of these families, an ADGRV1 variant was found at a homozygous state, in a female more severely affected than her heterozygous brother, suggesting a gene dosage effect. In the five families, GGE phenotype was statistically associated with ADGRV1 variants (0R = 0.9 103).Conclusion: This study highly supports, for the first time, the involvement of ADGRV1 missense variants in familial GGE and that ADGRV1 is a susceptibility gene for CAE/JAE and GGE-TCS phenotypes.
The Association Between Dairy Product Consumption and Asthenozoospermia Risk: A Hospital-Based Case-Control Study
Authors: Wang Xiao-Bin , Wu Qi-Jun , Liu Fang-Hua , Zhang Shuang , Wang Han-Yuan , Guo Ren-Hao , Leng Xu , Du Qiang , Zhao Yu-Hong , Pan Bo-Chen 
Published: October 2021

Background: Evidence of an association between dairy product and main related dairy nutrient intake, and the asthenozoospermia risk have been limited and controversial.Methods: A hospital-based case-control study including 549 men with asthenozoospermia and 581 normozoospermic controls was carried out in the infertility clinics of Shengjing Hospital of China Medical University between June, 2020 and December, 2020. Dietary intake was assessed with a validated food frequency questionnaire. According to the World Health Organization guidelines, semen parameters were collected through masturbation and were measured with WLJY9000 instrument and flow cytometry. The daily intake of dairy products and related nutrients was categorized into three groups according to control distribution, and the lowest tertile was used as the reference category. An unconditional multiple logistic regression was used to estimate the odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for asthenozoospermia risk.Results: After adjustment for potential confounders, we found no statistically significant associations between the intake of total dairy products and asthenozoospermia risk (ORT3vs.T1 = 1.19, 95%CI = 0.85–1.67). Additionally, we generated null findings regarding the main related nutrients from dairy, including protein (ORT3vs.T1 = 1.19, 95%CI = 0.85–1.68), fat (ORT3vs.T1 = 1.28, 95%CI = 0.91–1.80), calcium (ORT3vs.T1 = 1.20, 95%CI = 0.85–1.68), saturated fatty acids (ORT3vs.T1 = 1.30, 95%CI = 0.92–1.83), and phosphorous (ORT3vs.T1 = 1.18, 95%CI = 0.84–1.67), and the asthenozoospermia risk. Of note, after stratification by body mass index (BMI), and the saturated fatty acids consumption from dairy was significantly associated with a higher asthenozoospermia risk (ORT3vs.T1 = 1.76, 95%CI = 1.01–3.09) among participants with a BMI below 25 kg/m2.Conclusion: This study provided limited evidence of an association between the intake of total dairy products and the main related dairy nutrients including protein, fat, calcium, saturated fatty acids, and phosphorus, and the asthenozoospermia risk. Further studies are warranted to confirm our findings in the future.
Predicting the Initial Treatment Response to Transarterial Chemoembolization in Intermediate-Stage Hepatocellular Carcinoma by the Integration of Radiomics and Deep Learning
Authors: Peng Jie , Huang Jinhua , Huang Guijia , Zhang Jing 
Published: October 2021

ObjectivesWe aimed to develop radiology-based models for the preoperative prediction of the initial treatment response to transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) since the integration of radiomics and deep learning (DL) has not been reported for TACE.MethodsThree hundred and ten intermediate-stage HCC patients who underwent TACE were recruited from three independent medical centers. Based on computed tomography (CT) images, recursive feature elimination (RFE) was used to select the most useful radiomics features. Five radiomics conventional machine learning (cML) models and a DL model were used for training and validation. Mutual correlations between each model were analyzed. The accuracies of integrating clinical variables, cML, and DL models were then evaluated.ResultsGood predictive accuracies were showed across the two cohorts in the five cML models, especially the random forest algorithm (AUC = 0.967 and 0.964, respectively). DL showed high accuracies in the training and validation cohorts (AUC = 0.981 and 0.972, respectively). Significant mutual correlations were revealed between tumor size and the five cML models and DL model (each P &lt; 0.001). The highest accuracies were achieved by integrating DL and the random forest algorithm in the training and validation cohorts (AUC = 0.995 and 0.994, respectively).ConclusionThe radiomics cML models and DL model showed notable accuracy for predicting the initial response to TACE treatment. Moreover, the integrated model could serve as a novel and accurate method for prediction in intermediate-stage HCC.
Biological Predictors of De Novo Tumors in Solid Organ Transplanted Patients During Oncological Surveillance: Potential Role of Circulating TERT mRNA
Authors: Cangemi Michela , Zanussi Stefania , Rampazzo Enrica , Bidoli Ettore , Giunco Silvia , Tedeschi Rosamaria , Pratesi Chiara , Martorelli Debora , Casarotto Mariateresa , Martellotta Ferdinando , Schioppa Ornella , Serraino Diego , Steffan Agostino , De Rossi Anita , Dolcetti Riccardo , Vaccher Emanuela 
Published: October 2021

BackgroundDe novo tumors are a major cause of morbidity and mortality after long-term solid organ transplantation. Chronic immunosuppression strongly affects solid organ transplanted (SOT) patients’ immune system by promoting immune evasion strategies and reactivations of viruses with oncogenic potential, ultimately leading to cancer onset. In this scenario, an oncological Surveillance Protocol integrated with biobanking of peripheral blood samples and evaluation of immunovirological and molecular parameters was activated for SOT patients at CRO-IRCCS Aviano, with the aim of identifying suitable biomarkers of cancer development.MethodsAn exploratory longitudinal study was designed based on two serial peripheral blood samples collected at least three months apart. Forty nine SOT patients were selected and stratified by tumor onset during follow-up. Spontaneous T-cell responses to EBV, CMV and tumor associated antigens, EBV-DNA and CMV-DNA loads, and circulating TERT mRNA levels were investigated.ResultsSignificantly higher levels of circulating TERT mRNA were observed 3.5-23.5 months before and close to the diagnosis of cancer as compared to tumor-free patients. Plasmatic TERT mRNA levels &gt;97.73 copies/mL at baseline were significantly associated with the risk of developing de novo tumors (HR=4.0, 95%C.I. = 1.4-11.5, p=0.01). In particular, the risk significantly increased by 4% with every ten-unit increment in TERT mRNA (HR=1.04, 95%C.I. = 1.01-1.07, p=0.01).ConclusionsAlthough obtained in an exploratory study, our data support the importance of identifying early biomarkers of tumor onset in SOT patients useful to modulate the pace of surveillance visits.
The Problem of Improving the Strategic Planning of Development and Implementation of Cloud Software Products
Authors: Andreevskiy I. L. 
Published: October 2021

Aim. The presented study aims to substantiate the content of the problem of improving the strategic planning of production and implementation of cloud software products (CSPs).Tasks. The author analyzes the demand for cloud software products from the strategic perspective; analyzes the theoretical foundations of strategic planning; substantiates major enterprise goals in the development of SCPs in accordance with the goals and objectives of the national projects of the Russian Federation and the needs of user enterprises; classifies informatization enterprises engaged in the development of SCPs, making it possible to conduct a comparative audit of enterprises engaged in SCP development; develops the concept of strategic planning for informatization enterprises engaged in the development and implementation of SCPs.Methods. This study uses strategic planning tools, statistical analysis of the development of digitalization enterprises based on cloud software products, the systems approach, theory of the efficiency of strategic planning of SCP development and implementation, theory of emergence in the assessment of the activities of an interconnected chain of cloud digitalization enterprises, mechanisms for coordinating economic interests based on the theory of collective decision-making.Results. The pace of cloud digitalization of the Russian economy is insufficient and requires scientific, methodological, and government support. Well-known theoretical and methodological studies of strategic planning do not make allowance for the specific aspects of the activities of enterprises engaged in the production and implementation of SCPs and need to be further developed in this direction. The existing classification of SCPs does not fully meet the objectives of the national projects of the Russian Federation and the requirements of user enterprises. Enterprises engaged in the development and implementation of SCPs are classified to enable audit of the quality of their activities. The author proposes an original concept of improving the strategic planning of enterprises engaged in the development and implementation of SCPs.Conclusions. Resolving the issues identified by the author is an important national economic objective for improving the strategic planning of the activities of informatization enterprises engaged in the development and implementation of SCPs. Solving this problem is key to increasing the economic efficiency of both informatization enterprises and SCP user enterprises in the context of cloud information systems, improving the efficiency of digitalization of the country’s economy as a whole.
EFFECT OF CHICORY (CICHORIUM INTYBUS L.) LEAVES EXTRACT TO PROTECT CERTAIN LIVER ENZYMES IN MICE AGAINST CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY
Authors: Saddam A. C. 
Published: October 2021

Chicory contains dietary inulin and oligofructose compounds which have a beneficial effect on metabolism, as well as polyphenol type derivatives, which may be responsible for the antioxidant properties. The effect of different concentrations of the hydroalcoholic extract of dried powdered leaves of chicory on CCl4-induced hepatotoxicity in vivo in mice, has been studied. Thirty-five mice (20-30 g) of age four weeks were randomly divided into 5 groups (seven in each). The mice orally received three different concentrations of chicory leaves extract (CLE) before injection for 3 consecutive days by CCl4. The study showed that CCl4 caused elevation in serum GOT, GPT, and ALP activities in mice, but there was no pronounced elevation in total protein and albumin. Pretreatment of mice with 75, 150, and 300 mg/kg/bwt of CLE protected the liver against CCl4-induced cytotoxicity. CLE significantly (p<0.05) reduced the elevated level of cholesterol, triglycerides, and significantly increased the levels of HDL in the group of mice pretreated with CLE (150 mg/ kg); 145± 1.3, 243± 1.3, and 34± 1.2 mg/dl, respectively, compared with negative control (185± 1.4, 290± 1.4, and 21± 1.3 mg/dl, respectively). In contrast, serum fasting glucose and magnesium level in mice groups were not significantly different under the same conditions. CLE is potentially a good natural source for antioxidants and natural hepatoprotective as well as beneficial to who is suffering from hypercholesterolemia.
El profesor de inglés en los tiempos de uso de la tecnología
Authors: González Valencia Heriberto , Ramírez Valencia Astrid , Isaza Gómez German Darío 
Published: October 2021

Este artículo busca mostrar los resultados del análisis hecho frente a la relación existente entre la tecnología y el docente inglés, considerando su efecto en la educación de este en el contexto de la práctica docente, abordando la importancia de este educador en la era de la tecnología, utilizando como referencia sus reflexiones y comentarios. Respecto al tipo de investigación, se utilizó la cualitativa e interpretativa, tanto en la recolección de las muestras, así como en su el análisis interpretando las respuestas dadas por los participantes, que correspondieron a un grupo de estudiantes de práctica docente, se empleó un grupo discusión, dentro del cual se abordaron temáticas relacionadas con el uso de la tecnología, en el contexto educativo. Se concluyó que sí hay influencia de la tecnología en el ejercicio docente desarrollado por estos futuros profesores, por lo tanto, es indispensable que se generen espacios y condiciones para el uso pedagógico de estas herramientas, optimizadoras del ejercicio docente.
La didáctica y el paradigma del techo de cristal. una mirada desde el enfoque radical e inclusivo de la educación
Authors: De la Herrán Gascón Agustín 
Published: October 2021

La Didáctica es un centro de la Pedagogía. Pero la Pedagogía está descentrada, porque está desenraizada. Por tanto, el centro de la Didáctica no es el centro de la formación plena, comprendida como fenómeno. Hay un abismo entre el fenómeno y el conocimiento del fenómeno. Cuando, con sed, se bebe de una vasija de oro, el agua en su hueco es el centro. Si la mirada se engarza al recipiente y no al seno y al agua, será que se es idiota. Dice Zhuang zi (1999), un maestro de la Didáctica basada en la conciencia, que: “La nasa sirve para coger peces; cogido el pez, olvídate de la nasa”. Pero una nasa abierta no es útil: demasiado hueco desapercibido. También observa que “Reconocerse idiota es ya no ser muy idiota; reconocer el propio error es no estar ya en gran error. El gran error es el que nunca se llega a entender. La gran idiotez es la que dura toda la vida sin esclarecerla” (Chuang tzu, 1977).

El tiempo se acumula, tiempo sin reacción esencial de la Didáctica. Continuar el camino, fortalecerse, desarrollarse, no caerse… no equivalen, necesariamente, a marchar bien o a favorecer a los demás. De hecho, “los errores pueden ser consecuencia de haber pensado bien” (Saramago, 2000). Esto ocurre cuando, pudiendo haber aciertos miopes, no hay conciencia suficiente. La clave para la Didáctica no es el pensamiento, sino la conciencia. Para Zhuang zi (1999): “¡El no conocer es conocer! ¡Y el conocer es no conocer! ¿Quién conoce el conocimiento que consiste en no conocer?”. El centro de la formación no está en el pensar, en el conocimiento, el saber, la competencia, sino en el no saber, en la conciencia, en el autoconocimiento (esencial) y en la meditación. De lo anterior se deduce un posible tránsito evolutivo: de una Didáctica vigente, fundamentada en la enseñanza y el aprendizaje, a una Didáctica emergente y ancestral, basada en la conciencia de todos y en una educación plena. Sostenemos que esta “otra nueva educación” (Herrán, 1993, 1996), podría contar con una Didáctica así. El objetivo de este ensayo es mostrarlo y compartirlo.
Mengurangi Risiko Jatuh pada Lanjut Usia dengan Latihan Keseimbangan
Authors: Widagdo The Maria Meiwati , Sambudi Rambat 
Published: October 2021

Background: Population of elderly in Indonesia continues to grow. Physical changes in the elderly cause balance disturbances, increasing the risks of falling.
Objective: To determine balance training effectiveness on reducing risks of falls in elderly.
Methods: This study used a quasi-experimental design with control and intervention groups. Functional Reach Test (FRT) and Falls Efficacy Scale-International (FES-I) were used to assess balance function. The elderly in this study had risks of falling according to FRT and FES-I. Timed Get-up and Go Test was used to assess physical function. Education and balance exercises were given for 3 weeks to the intervention group. Pre-test data were taken at the beginning of the study, while post-test data after the balance training was given to the intervention group. Paired t-test was used to compare the pre-test and post-test data.
Results: Research was conducted in Warungboto and Giwangan Kampongs, Umbulharjo District, Yogyakarta Municipality. Data from 60 elderly: 30 in the intervention and 30 in the control groups. Paired t-test showed a significant difference between pre-test and post-test results in the intervention group on FRT (t=-16,301, p<0.001, and FES-I (t=-24,457, p<0.001). The three-week-balance-training significantly reduced the risk of falling in the intervention group. Significant difference was not found in the control group on FRT (t=-0.126, p=0.901), and FES-I (t=-0.764, p=0.451). There was no significant reduction in the risks of falls in the control group.
Conclusion: Balance training is effective in reducing the risk of falls in elderly.
Studi Pengaruh Kecepatan Potong Dan Kedalaman Pemotongan Terhadap Kekasaran Permukaan Benda Hasil Pembubutan Menggunakan Pahat HSS Terhadap Material St41
Authors: Wawanto Rendi , - Erwansyah , - Ariyanto 
Published: October 2021

In the machining process is very need high precision to get a good result. One of the benchmarks of the quality of the surface of the product workmanship in the machining process is surface roughness.
The research was aimed at determining the contribution of the parameters of the machining process conducted on lathes. The research was conducted using lathes with machining process parameters that vary from cutting speed, and depth of nutrition, as well as using fixed parameters of feeding. The experiment was conducted using experimental method with the amount of cutting speed value (Vc) used by St 41 material of 20-25 m/min. The values used in this study were limited to 20, 21, and 22 m/min (Vc) values and cutting depths of 0.5, 0.8, and 1.0 mm.
Research shows the results of turning (Vc) 20 m / min. best depth using a cutting depth of 0.5 mm with a surface roughness value (Ra) of 2,743 μm, and (Vc) of 21 m/min, the best depth using a depth of 0.5 mm with a surface roughness value (Ra)1,495 μm, and using (Vc) 22 m/min, the best depth uses a depth of 0.8 mm with a surface roughness value (Ra)1,376 μm. the best value of the turning process uses 3 cutting speeds and 3 cutting depths at the turning process using (Vc) 22 m/min with a depth of 0.8 mm with a surface roughness value (Ra)1,376 μm
PENGARUH PENERAPAN METODE JARIMATIKA TERHADAP KEMAMPUAN BERHITUNG PERKALIAN SISWA KELAS III DI SEKOLAH DASAR NEGERI 15 KOTO BARU DHARMASRAYA
Authors: Sari Murni Purnama , Hader Antik Estika , Sukron Muhammad 
Published: October 2021

Penelitian ini dilatar belakangi oleh hasil belajar peserta didik mengalami kesulitan dalam berhitung perkalian, hal ini karena peserta didik mengalami kesulitan dalam menghafal perkalian. Penelitian ini bertujuan untuk mengetahui Pengaruh Penerapan Metode Jarimatika Terhadap Kemampuan Berhitung Perkalian Siwa Kelas III SDN 15 Koto Baru, Dharmasraya.Jenis penelitian ini adalah penelitian Eksperimen Design Pretest-postest one group, dengan pendekatan kuantititatif. Subjek penelitan ini adalah siswa III SDN 15 Koto Baru, Dharmasraya. Pengambilan sampel penelitian ini menggunakan teknik pretest-postest yang terdiri dari 20 pesrta didik. Teknik pengumpulan data dilakukan pre-test dan post-test. Alat pengumpul data berupa soal pilihan ganda yang berjumlah 20 butir soal pre-test maupun post-test Melalui uji validasi,uji reabilitas. Data dianalisa menggunakan uji Normalitas, dan Uji Hipotesis/t-test yang diolah menggunakan SPSS 20. Berdasarkan deskripsi data hasil penelitian data hasil analisis pretest dan postest, dengan menggunakan uji Paired Sample tes menunjukkan nilai signifikasi 0,000 ˂ 0,05 maka hasil uji Paired sample tes dapat disimpulkan bahwa H0 ditolak dan Ha diterima. Dengan diterimanya Ha pada pengujian hipotesis tersebut, maka dapat disimpulkan bahwa penelitian ini dapat menguji kebenaran hipotesis yaitu terhadap peningkatan kemampuan dalam perkalian anatara sebelum dan sesudah diterapkannya metode jarimatika pada kelas III SDN 15 Koto Baru.