bluuebunny/crossref_metadata_2025_split huggingface dataset:
End of life in hospitalised prisoners: a group comparison of palliative medicine and hospital use
Authors: Panozzo Stacey , Bryan Tamsin , Marco David , Collins Anna , Lethborg Carrie , Philip Jennifer 
Published: February 2021

BackgroundProviding optimal palliative and end-of-life care for people in prison with advanced progressive disease is a growing challenge. This study aimed to examine hospital and palliative care utilisation for people in prison who are hospitalised during the final 3 months of life and to compare with a disease-matched non-incarcerated patient cohort.MethodsA retrospective cohort study of people in prison who died between 2009 and 2019 in an Australian public hospital that provides tertiary-level healthcare for 18% of Australia’s prison population. Demographic, clinical and service use data were extracted from medical records of eligible patients experiencing incarceration (prison group) and a disease-matched, non-incarcerated patient comparator group (comparator group).ResultsAt the time of death, patients in the prison group were aged a median of 20 years younger than the comparator group (median age 58 vs 78 years, p<0.01). The prison group experienced more than double the mean length of acute care hospital stay at the end of life. A higher proportion of patients in the prison group experienced an intensive care unit episode (22% vs 12%). More than two-thirds (71%) of the prison group patients were seen by palliative care prior to death, similar to the comparator group (p=0.44). Those transferred to the palliative care unit had a shorter length of stay and were admitted later, just prior to death (median 5 vs 8 days).ConclusionsPeople in prison have prolonged acute care public hospital stays and are more likely to experience escalation of care at the end of life. Future opportunity may exist for increased access to formal subacute care settings for people in prison with life-limiting illness to receive optimal palliative and end-of-life care.
Palliative medicine in the intensive care unit: needs, delivery, quality
Authors: A Hill Stephanie , Dawood Abdul , Boland Elaine , Leahy Hannah E , EM Murtagh Fliss 
Published: February 2021

Background15%–20% of critical care patients die during their hospital admission. This service evaluation assesses quality of palliative care in intensive care units (ICUs) compared with national standards.MethodsRetrospective review of records for all patients who died in four ICUs (irrespective of treatment limitation) between 1 June and 31 July 2019. Descriptive statistics reported for patient characteristics, length of stay, admission route, identification triggers and palliative care delivery.ResultsForty-five patients died, two records were untraced, thus N=43. The dying process was recognised in 88% (n=38). Among those where dying was recognised (N=35), 97% (34) had documented family discussion before death, 9% (3) were offered religious/spiritual support, 11% (4) had review of hydration/nutrition and 6% (2) had documented preferred place of death. Prescription of symptom control medications was complete in 71% (25) opioids, 34% (12) haloperidol, 54% (19) midazolam and 43% (15) hyoscine. Combining five triggers—length of stay >10 days prior to ICU admission 7% (3), multiorgan failure ≥3 systems 33% (14), stage IV malignancy 5% (2), post-cardiac arrest 23% (10) and intracerebral haemorrhage requiring mechanical ventilation 12% (5)—identified 60% (26) of patients. Referral to the palliative care team was seen in 14% (5), and 8% (3) had specialist palliative care team review.ConclusionsRecognition of dying was high but occurred close to death. Family discussions were frequent, but religious/spiritual needs, hydration/nutrition and anticipatory medications were less often considered. The ICUs delivered their own palliative care in conjunction with specialist palliative care input. Combining five triggers could increase identification of palliative care needs, but a larger study is needed.
Quantization of Einstein-aether scalar field cosmology
Authors: Dimakis N. , Pailas T. , Paliathanasis A. , Leon G. , Terzis Petros A. , Christodoulakis T. 
Published: February 2021

AbstractWe present, for the first time, the quantization process for the Einstein-aether scalar field cosmology. We consider a cosmological theory proposed as a Lorentz violating inflationary model, where the aether and scalar fields interact through the assumption that the aether action constants are ultra-local functions of the scalar field. For this specific theory there is a valid minisuperspace description which we use to quantize. For a particular relation between the two free functions entering the reduced Lagrangian the solution to the Wheeler–DeWitt equation as also the generic classical solution are presented for any given arbitrary potential function.
The mobility laws of location-based games
Authors: Tonetto Leonardo , Lagerspetz Eemil , Yi Ding Aaron , Ott Jörg , Tarkoma Sasu , Nurmi Petteri 
Published: February 2021

AbstractMobility is a fundamental characteristic of human society that shapes various aspects of our everyday interactions. This pervasiveness of mobility makes it paramount to understand factors that govern human movement and how it varies across individuals. Currently, factors governing variations in personal mobility are understudied with existing research focusing on explaining the aggregate behaviour of individuals. Indeed, empirical studies have shown that the aggregate behaviour of individuals follows a truncated Lévy-flight model, but little understanding exists of the laws that govern intra-individual variations in mobility resulting from transportation choices, social interactions, and exogenous factors such as location-based mobile applications. Understanding these variations is essential for improving our collective understanding of human mobility, and the factors governing it. In this article, we study the mobility laws of location-based gaming—an emerging and increasingly popular exogenous factor influencing personal mobility. We analyse the mobility changes considering the popular PokémonGO application as a representative example of location-based games and study two datasets with different reporting granularity, one captured through location-based social media, and the other through smartphone application logging. Our analysis shows that location-based games, such as PokémonGO, increase mobility—in line with previous findings—but the characteristics governing mobility remain consistent with a truncated Lévy-flight model and that the increase can be explained by a larger number of short-hops, i.e., individuals explore their local neighborhoods more thoroughly instead of actively visiting new areas. Our results thus suggest that intra-individual variations resulting from location-based gaming can be captured by re-parameterization of existing mobility models.
Intramedullary Cannulated Compression Screws for Extra-Articular Phalangeal Fractures
Authors: Reid Alex W. N. , Sood Manu K. 
Published: February 2021

Background: There is no consensus as to which is the best way to fix unstable extra-articular phalangeal fractures. We performed a literature review to determine outcomes using intramedullary cannulated compression screws. Methods: PubMed, Medline and Embase databases were searched for English language articles reporting the use of one or more intramedullary screw(s) for fixation of an acute extra-articular phalangeal fracture in adults that reported outcome data. Results: A total of 62 abstracts were identified, of which 14 full-text articles were eligible for full-text screening for the inclusion criteria. Of these 14 articles, seven articles were included in the final study. Data on 146 phalangeal fractures were aggregated with an average patient age of 36 (18–84). 89% (130/146) fractures were of the proximal phalanx, the remainder of the middle phalanx. Surgical technique was mostly a minimally invasive technique under fluoroscopy guidance using an anterograde technique. One paper described a retrograde method. Screw diameter varied from 2.2 mm to 3.2 mm. Where the radiographic union was reported, all fractures united. Range of motion averaged 231° (range 95°–295°) in four studies. Return to work was reported as 6.4 weeks (range 0.9–16.7 weeks) in one study. Different quality-of-life scores were reported by the studies (DASH 3.52 (range 1–45), QuickDASH score of 3.9 and DASH score of 3.9). Complications rate was 5% (8/146) including 5 major complications and 3 minor in the pooled results. Conclusions: This literature review demonstrates that fixation of extra-articular fractures of the proximal and middle phalanges with cannulated compression screws is a safe and successful surgical treatment with faster mobilization and return to work with fewer complications, including stiffness, than have been reported with plates and screws and percutaneous K-wires. This application is limited to transverse and short oblique extra-articular fractures.
Increased Mortality in Patients With Preoperative and Persistent Postoperative Pulmonary Hypertension Undergoing Mitral Valve Surgery for Mitral Regurgitation: A Cohort Study
Authors: Genuardi Michael V. , Shpilsky Daniel , Handen Adam , VanSpeybroeck Gabrielle , Canterbury Ann , Lu Michael , Shapero Kayle , Nieves Ricardo A. , Thoma Floyd , Mulukutla Suresh R. , Cavalcante João L. , Chan Stephen Y. 
Published: February 2021

Background
Preoperative pulmonary hypertension (PH) is associated with excess mortality among patients with severe mitral regurgitation undergoing mitral valve surgery (MVS). However, the links between PH phenotype, pulmonary vascular remodeling, and persistent postoperative PH are not well understood. We aimed to describe the associations between components of pulmonary hemodynamics as well as postoperative residual PH with longitudinal mortality in patients with severe mitral regurgitation who received MVS.

Methods and Results
Patients undergoing MVS for severe mitral regurgitation from 2011 to 2016 were retrospectively identified within our health system (n=488). Mean pulmonary artery pressure and other hemodynamic variables were determined by presurgical right‐heart catheterization. Postoperative pulmonary artery systolic pressure was assessed on echocardiogram 42 to 365 days post‐MVS. Longitudinal survival over a mean 3.9 years of follow‐up was evaluated using Cox proportional hazards modeling to compare survival after adjustment for demographics, surgical characteristics, and comorbidities. Pre‐MVS prevalence of PH was high at 85%. After adjustment, each 10‐mm Hg increase in preoperative mean pulmonary artery pressure was associated with a 1.38‐fold increase in risk of death (95% CI, 1.13–1.68). Elevated preoperative pulmonary vascular resistance, transpulmonary gradient, and right atrial pressure were similarly associated with increased mortality. Among 231 patients with postoperative echocardiogram, evidence of PH on echocardiogram (pulmonary artery systolic pressure ≥35 mm Hg) was associated with increased risk of death (hazard ratio [HR], 2.02 [95% CI, 1.17–3.47]); however, this was no longer statistically significant after adjustment (HR, 1.55 [95% CI, 0.85–2.85]).

Conclusions
In patients undergoing MVS for mitral regurgitation, preoperative PH, and postoperative PH were associated with increased mortality.
Cardiac Arrest Induced by Asphyxia Versus Ventricular Fibrillation Elicits Comparable Early Changes in Cytokine Levels in the Rat Brain, Heart, and Serum
Authors: Uray Thomas , Dezfulian Cameron , Palmer Abigail A. , Miner Kristin M. , Leak Rehana K. , Stezoski Jason P. , Janesko‐Feldman Keri , Kochanek Patrick M. , Drabek Tomas 
Published: February 2021

Background
Current postresuscitative care after cardiac arrest (CA) does not address the cause of CA. We previously reported that asphyxial CA (ACA) and ventricular fibrillation CA (VFCA) elicit unique injury signatures. We hypothesized that the early cytokine profiles of the serum, heart, and brain differ in response to ACA versus VFCA.

Methods and Results

Adult male rats were subjected to 10 minutes of either ACA or VFCA. Naives and shams (anesthesia and surgery without CA) served as controls (n=12/group). Asphyxiation produced an ≈4‐minute period of progressive hypoxemia followed by a no‐flow duration of ≈6±1 minute. Ventricular fibrillation immediately induced no flow. Return of spontaneous circulation was achieved earlier after ACA compared with VFCA (42±18 versus 105±22 seconds;
P
<0.001). Brain cytokines in naives were, in general, low or undetectable. Shams exhibited a modest effect on select cytokines. Both ACA and VFCA resulted in robust cytokine responses in serum, heart, and brain at 3 hours. Significant regional differences pinpointed the striatum as a key location of neuroinflammation. No significant differences in cytokines, neuron‐specific enolase, S100b, and troponin T were observed across CA models.

Conclusions
Both models of CA resulted in marked systemic, heart, and brain cytokine responses, with similar degrees of change across the 2 CA insults. Changes in cytokine levels after CA were most pronounced in the striatum compared with other brain regions. These collective observations suggest that the amplitude of the changes in cytokine levels after ACA versus VFCA may not mediate the differences in secondary injuries between these 2 CA phenotypes.
Rural Life in Late Socialism
Authors: Wilcox Phill , Rigg Jonathan , Nguyen Minh T.N. 
Published: February 2021

Abstract
Late socialist countries are transforming faster than ever. Across China, Laos and Vietnam, where market economies coexist with socialist political rhetoric and the Communist party state’s rule, sweeping processes of change open up new vistas of imaginaries of the future alongside uncertainty and anxiety. These countries are three of very few living examples that combine capitalist economics with party state politics. Consequently, societal transformations in these contexts are subject to pressures and agendas not found elsewhere, and yet they are no less subject to global forces than elsewhere. As all three countries maintain substantial rural populations, and because those rural areas are themselves places of change, how rural people across these changing contexts undertake future making is a timely and significant question. The contributions in the issue address this question by engaging with lived experiences and government agendas across Laos, China and Vietnam, showing a politics of development in which desire and hope are entangled with the contradictions and struggles of late socialism.
Privacy as a New Component of “The Best Interests of the Child” in the New Digital Environment
Authors: Kravchuk Natasha 
Published: February 2021

Abstract
Legal regulations codifying the privacy rights of children in digital contexts, both at national and international levels, are fragmentary. Existing norms primarily address issues related to child safety as well as data processing, but not the protection of his/her dignity and reputation. At the same time, the Internet Communications and Technology-related (ict) activities of parents, who are traditionally considered to be the primary defenders of their children’s rights but presently are the main contributors to the public image of their child, may endanger child privacy. To address the threat that “sharenting” creates, the privacy of the child should be considered not only as a right, but also in “the best interests of the child”. This conceptualisation of rights as argued, would allow for a greater degree of privacy protection as it requires authorities to take it into consideration, ‘in all actions concerning children’, and will guarantee that they allocate to it the proper weight, while balancing it with the rights of others.
A High-Resolution Flood Inundation Archive (2016–the Present) from Sentinel-1 SAR Imagery over CONUS
Authors: Yang Qing , Shen Xinyi , Anagnostou Emmanouil N. , Mo Chongxun , Eggleston Jack R. , Kettner Albert J. 
Published: February 2021

AbstractMost existing inundation inventories are based on surveys, news, or passive remote sensing imagery. Affected by spatiotemporal resolution or weather conditions, these inventories are limited in spatial details or coverage. Satellite synthetic aperture radar (SAR) data have recently enabled flood mapping at unprecedented spatiotemporal resolution. However, the bottleneck in producing SAR-based flood maps is the requirement of expert manual processing to maintain acceptable accuracy by most SAR-driven mapping techniques. To fill the vacancy, we generate a high-resolution (10 m) flood inundation dataset over the contiguous United States (CONUS) from nearly the entire Sentinel-1 SAR archive (from January 2016 to the present), using a recently developed automated Radar Produced Inundation Diary (RAPID) system. RAPID uses U.S. Geological Survey (USGS) water watch system and accumulated precipitation to identify SAR images that potentially overlap a flood event. The dataset include inundation events with the temporal scale from several days to months. Concluded from all 559 overlapping images in the period from 2016 to the first half of 2019, the comparison of the proposed dataset against the USGS Dynamic Surface Water Extent (DSWE) product yields an overall, user, producer agreements, and critical success index of 99.06%, 87.63%, 91.76%, and 81.23%, respectively, demonstrating the high accuracy of the proposed dataset and the robustness of the automated system. We anticipate this archive to facilitate many applications, including large-scale flood loss and risk assessment, and inundation model calibration and validation.
Influence of Nature at the Time of the Pandemic: An Experience-Based Survey at the Time of SARS-CoV-2 to Demonstrate How Even a Short Break in Nature Can Reduce Stress for Healthcare Staff
Authors: Gola Marco , Botta Monica , D’Aniello Anna Lisa , Capolongo Stefano 
Published: February 2021

Aim: The current COVID-19 pandemic has been causing significant upheavals in the daily lives of citizens and consequently also their mood (stress, distraction, anxiety, etc.), especially during the lockdown phase. The aim of the investigation is to evaluate the benefits of 20–30 minutes in contact with nature. Background: The Scientific Community, also through the evidence-based design approach, has already demonstrated the importance of greenery and nature on the psychophysical well-being of people and, in a moment of emergency, contact with the nature can be therapeutic and quite influential on the mental health of staff subject to stress. Method: During the lockdown, an Italian multidisciplinary working group promoted an experience-based survey, based on the Profile of Mood States methodology, for measuring the psychophysical well-being of hospital staff. Results: The author collected 77 questionnaires. The benefits that users have obtained from the experience in nature have been investigated by comparing the type of stresses they were subjected to and highlighting various peculiarities in the data analysis associated with the type of green in which they carried out the survey, the healthcare areas in which they worked during the pandemic emergency, and the moment in which the survey was conducted. Conclusions: The study has highlighted that a short break in green spaces strongly influenced the mental and psychophysical well-being of hospital staff, emphasizing the importance of nearby green spaces in architectures for health. Even a brief break in nature can regenerate users, especially in times of a stressful health emergency.
Complications and Revisions After Spine Surgery in Patients With Skeletal Dysplasia: Have We Improved?
Authors: Shafi Karim , Lovecchio Francis , Sava Maria , Steinhaus Michael , Samuel Andre , Carter Erin , Lebl Darren , Farmer James , Raggio Cathleen 
Published: February 2021

Study Design: Retrospective case series. Objective: To report contemporary rates of complications and subsequent surgery after spinal surgery in patients with skeletal dysplasia. Methods: A case series of 25 consecutive patients who underwent spinal surgery between 2007 and 2017 were identified from a single institution’s skeletal dysplasia registry. Patient demographics, medical history, surgical indication, complications, and subsequent surgeries (revisions, extension to adjacent levels, or for pathology at a non-contiguous level) were collected. Charlson comorbidity indices were calculated as a composite measure of overall health. Results: Achondroplasia was the most common skeletal dysplasia (76%) followed by spondyloepiphyseal dysplasia (20%); 1 patient had diastrophic dysplasia (4%). Average patient age was 53.2 ± 14.7 years and most patients were in excellent cardiovascular health (88% Charlson Comorbidity Index 0-4). Mean follow up after the index procedure was 57.4 ± 39.2 months (range). Indications for surgery were mostly for neurologic symptoms. The most commonly performed surgery was a multilevel thoracolumbar decompression without fusion (57%). Complications included durotomy (36%), neurologic complication (12%), and infection requiring irrigation and debridement (8%). Nine patients (36%) underwent a subsequent surgery. Three patients (12%) underwent a procedure at a non-contiguous anatomic zone, 3 (12%) underwent a revision of the previous surgery, and another 3 (12%) required extension of their previous decompression or fusion. Conclusions: Surgical complication rates remain high after spine surgery in patients with skeletal dysplasia, likely attributable to inherent characteristics of the disease. Patients should be counseled on their risk for complication and subsequent surgery.
ATG5 promotes eosinopoiesis but inhibits eosinophil effector functions
Authors: Germic Nina , Hosseini Aref , Stojkov Darko , Oberson Kevin , Claus Meike , Benarafa Charaf , Calzavarini Sara , Angelillo-Scherrer Anne , Arnold Isabelle C. , Müller Anne , Riether Carsten , Yousefi Shida , Simon Hans-Uwe 
Published: February 2021

AbstractEosinophils are white blood cells that contribute to the regulation of immunity and are involved in the pathogenesis of numerous inflammatory diseases. In contrast to other cells of the immune system, no information is available regarding the role of autophagy in eosinophil differentiation and functions. To study the autophagic pathway in eosinophils, we generated conditional knockout mice in which Atg5 is deleted within the eosinophil lineage only (designated Atg5eoΔ mice). Eosinophilia was provoked by crossbreeding Atg5eoΔ mice with Il5 (IL-5) overexpressing transgenic mice (designated Atg5eoΔIl5tg mice). Deletion of Atg5 in eosinophils resulted in a dramatic reduction in the number of mature eosinophils in blood and an increase of immature eosinophils in the bone marrow. Atg5-knockout eosinophil precursors exhibited reduced proliferation under both in vitro and in vivo conditions but no increased cell death. Moreover, reduced differentiation of eosinophils in the absence of Atg5 was also observed in mouse and human models of chronic eosinophilic leukemia. Atg5-knockout blood eosinophils exhibited augmented levels of degranulation and bacterial killing in vitro. Moreover, in an experimental in vivo model, we observed that Atg5eoΔ mice achieve better clearance of the local and systemic bacterial infection with Citrobacter rodentium. Evidence for increased degranulation of ATG5low-expressing human eosinophils was also obtained in both tissues and blood. Taken together, mouse and human eosinophil hematopoiesis and effector functions are regulated by ATG5, which controls the amplitude of overall antibacterial eosinophil immune responses.