bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting the Amplitude of Thermoacoustic Instability Using Universal Scaling Behavior
Authors: Pavithran Induja , Unni Vishnu R. , Saha Abhishek , Varghese Alan J. , Sujith R. I. , Marwan Norbert , Kurths Jürgen 
Published: August 2021

Abstract
The complex interaction between the turbulent flow, combustion and the acoustic field in gas turbine engines often results in thermoacoustic instability that produces ruinously high-amplitude pressure oscillations. These self-sustained periodic oscillations may result in a sudden failure of engine components and associated electronics, and increased thermal and vibrational loads. Estimating the amplitude of the limit cycle oscillations that are expected during thermoacoustic instability helps in devising strategies to mitigate and to limit the possible damages due to thermoacoustic instability. We propose two methodologies to estimate the amplitude using only the pressure measurements acquired during stable operation. First, we use the universal scaling relation of the amplitude of the dominant mode of oscillations with the Hurst exponent to predict the amplitude of the limit cycle oscillations. We also present a methodology to estimate the amplitudes of different modes of oscillations separately using “spectral measures,” which quantify the sharpening of peaks in the amplitude spectrum. The scaling relation enables us to predict the peak amplitude at thermoacoustic instability, given the data during the safe operating condition. The accuracy of prediction is tested for both methods, using the data acquired from a laboratory-scale turbulent combustor. The estimates are in good agreement with the actual amplitudes.
Delay Identification in Thermoacoustics
Authors: Gant F. , Ghirardo G. , Cuquel A. , Bothien M. R. 
Published: August 2021

Abstract
The stability of thermoacoustic systems is often regulated by the time delay between acoustic perturbations and corresponding heat release fluctuations. An accurate estimate of this value is of great importance in applications since even small modifications can introduce significant changes in the system behavior. Different studies show that the nonlinear delayed dynamics typical of these systems can be well captured with low-order models. In this work, a method is introduced to estimate the most likely value of the time delay of a single thermoacoustic mode from a measured acoustic pressure signal. The mode of interest is modeled by an oscillator equation, with a nonlinear delayed forcing term modeling the deterministic flame contribution and an additive white Gaussian noise to embed the stochastic combustion noise. Additionally, other thermoacoustic relevant parameters are estimated. The model accounts for a flame gain, for a flame saturation coefficient, for linear acoustic damping, and for the background combustion noise intensity. The pressure data time series is statistically analyzed and the set of unknown parameters is identified. Validation is performed with respect to synthetically generated time series and low order model simulations, for which the underlying delay is known a priori. A discussion follows about the accuracy of the method, in particular, a comparison with existing methods is drawn.
Liquid-Cooled Heat Sink Optimization for Thermal Imbalance Mitigation in Wide-Bandgap Power Modules
Authors: Sahu Raj , Gurpinar Emre , Ozpineci Burak 
Published: August 2021

Abstract
Power semiconductor die placement on substrates used in high-power modules is generally optimized to minimize electrical parasitic (e.g., stray inductance, common-mode capacitance), taking into account the minimum spacing between semiconductor dies for thermal decoupling. The layout assumes sufficient heat spreading and transfer from dies to the cooling structure. Insulated metal substrate-based power module designs may lead to asymmetrical thermal resistance across the dies, which may cause significant temperature differences among the devices. Such unintentional thermal asymmetries can lead to oversizing the cooling system design or underusing the semiconductor power processing capability. This article proposes a thermal imbalance mitigation method that uses evolutionary optimized liquid-cooled heat sinks to improve the thermal loading among devices.
Advancement of Chip Stacking Architectures and Interconnect Technologies for Image Sensors
Authors: Lu Mei-Chien 
Published: August 2021

Abstract
Numerous technology breakthroughs have been made in image sensor development in the past two decades. Image sensors have evolved into a technology platform to support many applications. Their successful implementation in mobile devices has accelerated market demand and established a business platform to propel continuous innovation and performance improvement extending to surveillance, medical, and automotive industries. This overview briefs the general camera module and the crucial technology elements of chip stacking architectures and advanced interconnect technologies. This study will also examine the role of pixel electronics in determining the chip stacking architecture and interconnect technology of choice. It is conducted by examining a few examples of CMOS image sensors (CIS) for different functions such as visible light detection, single photon avalanche photodiode (SPAD) for low light detection, rolling shutter, and global shutter, and depth sensing and light detection and ranging (LiDAR). Performance attributes of different architectures of chip stacking are overviewed. Direct bonding followed by Via-last through silicon via (Via-last TSV) and hybrid bonding (HB) technologies are identified as newer and favorable chip-to-chip interconnect technologies for image sensor chip stacking. The state-of-the-art ultrahigh-density interconnect manufacturability is also highlighted.
Assembly Reliability and Molding Material Comparison of Miniature Integrated High Power Module With Insulated Metal Substrate
Authors: Lee Chang-Chun , Kao Kuo-Shu , Wang Chi-Wei , Yu Tai-Jyun , Lee Tai-Kuang , Chiu Po-Kai 
Published: August 2021

Abstract
Given the increasing demand for power density and lightweight specifications, the discrete transistor outline-type package is no longer sufficient for personal vehicle. The new generation of high-power drive needs excellent heat dissipation and miniaturized system simultaneously. However, a traditional architecture of power module, direct bonding copper substrate, has serious warpage deformation and limitation of the heat dissipation. Therefore, a power module with an insulated metal substrate (IMS) is proposed. The proposed power module has a smaller volume, better electrical and thermal performance, and high reliability to be utilized in personal vehicles. A fine-quality assembly process is also presented and verified. Furthermore, two different kinds of molding materials that are widely used in power modules, silicone gel, and epoxy, are utilized. The IMS-type module with silicone gel molding fails the temperature cycling test (TCT) with the delamination of the solder layer. The module with epoxy successfully passes the automotive-grade reliability tests, including TCT, highly accelerated stress test, high-temperature reverse bias, and intermittent operational life test according to the standard of AEC-Q101. The finite element analysis for the IMS power module is presented and analyzed under the condition of TCT to estimate the mechanical behavior of the solder layer. The equivalent plastic strain of solder layer with silicone gel and epoxy is 0.76 and 0.08, respectively, after TCT, separately. The main reason can be attributed to the coefficient of thermal expansion between the IMS and molding material. According to the analyzed results, the effect of molding material should not be ignored in the power modulus.
Immunoreactive Protein Repertoires of Ehrlichia chaffeensis and E. canis Reveal the Dominance of Hypothetical Proteins and Conformation-Dependent Antibody Epitopes
Authors: Luo Tian , Patel Jignesh G. , Zhang Xiaofeng , Walker David H. , McBride Jere W. 
Published: August 2021

The immunomes of
Ehrlichia chaffeensis
and
Ehrlichia canis
have recently been revised to include immunodominant hypothetical proteins with conformational antibody epitopes. In this study, we examined 216
E. chaffeensis
and 190
E. canis
highly antigenic proteins according to ANTIGENpro and also performed a genome-wide hypothetical protein analysis (
E. chaffeensis
n
= 104;
E. canis
n
= 124) for immunoreactivity.
Metformin for the treatment of breast cancer: protocol for a scoping review of randomised clinical trials
Authors: Araujo Carolina Fumico Massuda , Nunes Lélia Cápua , Murta-Nascimento Cristiane , Souza Cristiano de Pádua , Bragagnoli Arinilda Campos , Fukushima Fernanda Bono , Vidal Edison Iglesias de Oliveira 
Published: August 2021

IntroductionInnovation through the repurposing of generic drugs encloses several advantages when compared with the process of developing new drugs from scratch. Metformin is an established and inexpensive antidiabetic drug for which anticancer properties have been hypothesised. A systematic review of observational studies found promising results for metformin related to breast cancer in women with diabetes. Although the number of randomised clinical trials of metformin for the treatment of breast cancer increased over the last decades, the overall landscape of those studies in this heterogeneous field remains unclear. Hence, we designed the present scoping review protocol to map the literature on randomised clinical trials of metformin in the treatment of breast cancer to determine the value and scope of future systematic reviews on this subject and identify research gaps.MethodsWe will search MEDLINE (via PubMed), EMBASE, CENTRAL, LILACS, Web of Science and sources of grey literature. We will include any randomised clinical trial of metformin for the treatment of breast cancer in adult women, and will not impose restrictions regarding context, language or publication date. Two independent reviewers will screen and select studies, and chart the data. We will structure the presentation of our results based on the molecular types of breast cancer, their stages and treatment modalities.Ethics and disseminationAs a literature review, this study is exempt from ethics approval. Findings will be disseminated through presentations in conferences and a peer-reviewed publication.Open Science Framework registrationosf.io/yquba.
Yoga, cognitive–behavioural therapy versus education to improve quality of life and reduce healthcare costs in people with endometriosis: a randomised controlled trial
Authors: Mikocka-Walus Antonina , Druitt Marilla , O"Shea Melissa , Skvarc David , Watts Jennifer J , Esterman Adrian , Tsaltas Jim , Knowles Simon , Harris Jill , Dowding Charlotte , Parigi Elesha , Evans Subhadra 
Published: August 2021

IntroductionEndometriosis is a debilitating chronic inflammatory condition highly burdensome to the healthcare system. The present trial will establish the efficacy of (1) yoga and (2) cognitive–behavioural therapy (CBT), above (3) education, on quality of life, biopsychosocial outcomes and cost-effectiveness.Methods and analysisThis study is a parallel randomised controlled trial. Participants will be randomly allocated to yoga, CBT or education. Participants will be English-speaking adults, have a diagnosis of endometriosis by a qualified physician, with pain for at least 6 months, and access to internet. Participants will attend 8 weekly group CBT sessions of 120 min; or 8 weekly group yoga sessions of 60 min; or receive weekly educational handouts on endometriosis. The primary outcome measure is quality of life. The analysis will include mixed-effects analysis of variance and linear models, cost–utility analysis from a societal and health system perspective and qualitative thematic analysis.Ethics and disseminationEnrolment in the study is voluntary and participants can withdraw at any time. Participants will be given the option to discuss the study with their next of kin/treating physician. Findings will be disseminated via publications, conferences and briefs to professional organisations. The University’s media team will also be used to further disseminate via lay person articles and media releases.Trial registration numberACTRN12620000756921p; Pre-results.
Effect of a smartphone application (Perx) on medication adherence and clinical outcomes: a 12-month randomised controlled trial
Authors: Li Ang , Del Olmo M Gail , Fong Mackenzie , Sim Kyra , Lymer Sharyn J , Cunich Michelle , Caterson Ian 
Published: August 2021

ObjectiveTo determine whether the Perx app improves medication adherence and clinical outcomes over 12 months compared with standard care in patients requiring polypharmacy.DesignRandomised controlled trial with 12-month follow-up.SettingOutpatient clinics in three tertiary hospitals in Sydney, Australia.ParticipantsEligible participants were aged 18–75 years, with at least one chronic condition, taking ≥3 different medications (oral medications or injections), with smartphone accessibility. Participants were randomised in a 1:1 ratio.InterventionsThe intervention group used the Perx app that contained customised reminders and gamified interactions to reward verified medication adherence.Main outcome measuresThe primary outcome was medication adherence over 12 months measured using pill counts. Secondary outcomes included clinical outcomes (haemoglobin A1c (HbA1c), cholesterol, blood glucose, triglycerides, creatinine, thyroid function, blood pressure and weight).ResultsOf 1412 participants screened for eligibility, 124 participants were randomised; 45 in the Perx arm and 40 in the control arm completed the study. The average age was 59.5, 58.9% were women, chronic conditions were cardiovascular disease (78%), type 2 diabetes (75%), obesity (65%) or other endocrine disorders (18%). On average, participants were taking six medications daily. The Perx group had greater improvements in adherence at month 2 (Coef. 8%; 95% CI 0.01 to 0.15), month 3 (Coef. 7%; 95% CI 0.00 to 0.14) and month 12 (Coef. 7%; 95% CI 0.00 to 0.13). The probability of HbA1c ≤6.5% was greater in the Perx group at months 9 and 12 and cholesterol (total and low-density lipoprotein cholesterol) was lower in the Perx group at month 3. The intervention was particularly effective for those with obesity, taking medications for diabetes and taking ≤4 medications.ConclusionsThis study provides evidence that app-based behavioural change interventions can increase medication adherence and produce longer-term improvements in some clinical outcomes in adults managing multimorbidity. More trials are needed to build the evidence base.Trial registration numberACTRN12617001285347.
Rationale and design of the IRON-AF study: a double-blind, randomised, placebo-controlled study to assess the effect of intravenous ferric carboxymaltose in patients with atrial fibrillation and iron deficiency
Authors: Tu Samuel J , Elliott Adrian D , Hanna-Rivero Nicole , Gallagher Celine , Mishima Ricardo S , Lyrtzis Ellen , Wlochowicz Danielle , Clarke Nicholas AR , Roberts-Thomson Kurt C , Stokes Michael B , Emami Mehrdad , Lau Dennis H , Sanders Prashanthan , Wong Christopher X 
Published: August 2021

IntroductionAtrial fibrillation (AF) is associated with significantly impaired quality-of-life. Iron deficiency (ID) is prevalent in patients with AF. Correction of ID in other patient populations with intravenous iron supplementation has been shown to be a safe, convenient and effective way of improving exercise tolerance, fatigue and quality-of-life. The IRON-AF (Effect of Iron Repletion in Atrial Fibrillation) study is designed to assess the effect of iron repletion with intravenous ferric carboxymaltose in patients with AF and ID.Methods and analysisThe IRON-AF study is a double-blind, randomised controlled trial that will recruit at least 84 patients with AF and ID. Patients will be randomised to receive infusions of either ferric carboxymaltose or placebo, given in repletion and then maintenance doses. The study will have follow-up visits at weeks 4, 8 and 12. The primary endpoint is change in peak oxygen uptake from baseline to week 12, as measured by cardiopulmonary exercise testing (CPET) on a cycle ergometer. Secondary endpoints include changes in quality-of-life and AF disease burden scores, blood parameters, other CPET parameters, transthoracic echocardiogram parameters, 6-minute walk test distance, 7-day Holter/Event monitor burden of AF, health resource utilisation and mortality.Ethics and disseminationThe study protocol has been approved by the Central Adelaide Local Health Network Human Research Ethics Committee, Australia. The results of this study will be disseminated through publications in peer-reviewed journals and conference presentations.Trial registration numberAustralian New Zealand Clinical Trials Registry (ACTRN12620000285954).
Utility of the FebriDx point-of-care assay in supporting a triage algorithm for medical admissions with possible COVID-19: an observational cohort study
Authors: Houston Hamish , Deas Gavin , Naik Shivam , Shah Kamal , Patel Shiras , Greca Dottori Maria , Tay Michael , Filson Sarah Ann , Biggin-Lamming James , Ross John , Vaughan Natalie , Vaid Nidhi , Gopal Rao Guduru , Amin Amit K , Gupta-Wright Ankur , John Laurence 
Published: August 2021

ObjectiveTo evaluate a triage algorithm used to identify and isolate patients with suspected COVID-19 among medical patients needing admission to hospital using simple clinical criteria and the FebriDx assay.DesignRetrospective observational cohort.SettingLarge acute National Health Service hospital in London, UK.ParticipantsAll medical admissions from the emergency department between 10 August 2020 and 4 November 2020 with a valid SARS-CoV-2 RT-PCR result.InterventionsMedical admissions were triaged as likely, possible or unlikely COVID-19 based on clinical criteria. Patients triaged as possible COVID-19 underwent FebriDx lateral flow assay on capillary blood, and those positive for myxovirus resistance protein A (a host response protein) were managed as likely COVID-19.Primary outcome measuresDiagnostic accuracy (sensitivity, specificity and predictive values) of the algorithm and the FebriDx assay using SARS-CoV-2 RT-PCR from nasopharyngeal swabs as the reference standard.Results4.0% (136) of 3443 medical admissions had RT-PCR confirmed COVID-19. Prevalence of COVID-19 was 46% (80/175) in those triaged as likely, 4.1% (50/1225) in possible and 0.3% (6/2033) in unlikely COVID-19. Using a SARS-CoV-2 RT-PCR reference standard, clinical triage had sensitivity of 96% (95% CI 91% to 98%) and specificity of 61.5% (95% CI 59.8% to 63.1%), while the triage algorithm including FebriDx had sensitivity of 93% (95% CI 87% to 96%) and specificity of 86.4% (95% CI 85.2% to 87.5%). While 2033 patients were deemed not to require isolation using clinical criteria alone, the addition of FebriDx to clinical triage allowed a further 826 patients to be released from isolation, reducing the need for isolation rooms by 9.5 per day, 95% CI 8.9 to 10.2. Ten patients missed by the algorithm had mild or asymptomatic COVID-19.ConclusionsA triage algorithm including the FebriDx assay had good sensitivity and was useful to ‘rule-out’ COVID-19 among medical admissions to hospital.
Advanced prostate cancer experimental radioactive treatment—clinical trial decision making: patient experiences
Authors: Viljoen Bianca , Hofman Michael S , Chambers Suzanne K , Dunn Jeff , Dhillon Haryana , Davis Ian D , Ralph Nicholas 
Published: August 2021

ObjectivesNested qualitative studies within clinical trials provide the opportunity to better understand participant experiences of participation and identify areas where improved support is required. The purpose of this qualitative study is to describe the lived experiences of men with advanced prostate cancer participating in the TheraP trial; a randomised trial of177Lu-PSMA-617 compared with cabazitaxel chemotherapy.MethodsFifteen men with advanced prostate cancer were recruited from the TheraP clinical trial and interviewed at three time points during the trial. Interviews were inductively analysed using thematic analysis. This research paper reports the results from the baseline interview at commencement of the trial, focusing specifically on participants’ enrolment experiences.ResultsFour themes were identified representing the lived experiences of men with advanced prostate cancer deciding to participate in the TheraP trial: (1) hoping to survive; (2) needing to feel informed; (3) choosing to participate and (4) being randomised. The process of deciding to enrol in a clinical trial is filled with indecision, emotional difficulties and focused on a desire to live.ConclusionsFor men with advanced prostate cancer, the experience of deciding to enrol in a clinical trial is principally driven by a desire to survive but interlinked with the need to make an informed decision as participants in this study expressed a preference for allocation to the experimental arm. Men seeking to enrol in clinical trials of new prostate cancer treatments would benefit from improved informational and decision support.Trial registration numberNCT03392428, ANZUP1603.
Impact of puberty as threshold to differentiate outcome of out-of-hospital cardiac arrest care groups: a nationwide observational study in France
Authors: Privat Elodie , Baert Valentine , Escutnaire Joséphine , Dumont Cyrielle , Recher Morgan , Genin Michael , Leclerc Francis , Hubert Hervé , Leteurtre Stephane 
Published: August 2021

BackgroundSince 2005, the international guidelines for out-of-hospital cardiac arrest (OHCA) use puberty to differentiate paediatric and adult care. This threshold is mainly relied on the more frequent respiratory aetiologies in children. Hitherto, to the best of our knowledge, no study has compared the characteristics and outcomes of non-pubescent children, adolescents and adult patients with OHCA. In this study, we intended to describe the characteristics, outcome and factors associated with survival of patients who experienced OHCA in the three groups: children, adolescents (pubescent<18 years) and adults (<65 years), to assess the pertinence of the guidelines.MethodsData from the French national cardiac arrest registry (2012–2017) were used in this nationwide observational study. Victims of OHCA who were <65 years old were included. The characteristics and outcomes of children and adolescents, and adolescents and adults were compared. Logistic regression was performed in each group to identify factors associated with survival at day 30.ResultsWe included 934 children, 433 adolescents and 26 952 adults. Respiratory aetiology was more frequent and shockable rhythm less frequent in children compared with adolescents (25.5% vs 17.2%, p=0.025 and 2.4% vs 6.8%, p<0.001, respectively). However, these differences were not observed between adolescents and adults (17.2% vs 14.1%, p=0.266 and 6.8% vs 10%, p=0.055, respectively). Between children and adolescents, and adolescents and adults, there was no significant difference in survival at day 30 (8.6%vs 9.8% and 9.8% vs 8.5%, respectively). For all groups, shockable initial rhythm was a factor of survival.ConclusionFrequency of respiratory aetiologies and shockable rhythm were common in adolescents and adults and different between children and adolescents. These results indicate that puberty as a threshold in international guidelines seems to be relevant.