bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of patient satisfaction after levonorgestral containing intrauterine system insertion in women with abnormal uterine bleeding
Authors: Dave Anupama , Sinha Kirti , Gupta Nidhi 
Published: December 2021

Background: Abnormal uterine bleeding is a common gynecological complaint affecting 10-30% of reproductive-aged women and it can result from different causes which adversely affects the woman’s quality of life, necessitating its appropriate and adequate management. Among all the pharmacological and surgical management options of AUB. LNG-IUS is emerging as a safer and effective treatment option of AUB. However apprehension about discomfort associated with the use of intrauterine device leads to its untimely removal. Aim of current study was to conduct a prospective qualitative study to observe the level of patient satisfaction with the use of LNG-IUS in patients with abnormal uterine bleeding.Methods: This study was conducted in the department of obstetrics and gynecology, MGM medical college and M.Y. Group of Hospitals, Indore from March 2017- March 2018. Follow up was done at 1, 3, 6 months.Results: In our study, majority of the women (90%) had improvement in their abnormal uterine bleeding along with significant increase in mean hemoglobin level from7.30+1.29 gm% to 8.71+1.27 gm% at the end of six months. 86.66% of these patients were very satisfied with the use of LNG IUS,Conclusions: LNG-IUS is an effective device for medical management of AUB and it should be used as the first line therapy for the same. It should always be considered before surgical interventions. It yields promising result in terms of patient satisfaction.
Quebrando as correntes: a produção do conhecimento em face a outras outras epistemologias
Authors: Martins Cynthia Carvalho 
Published: December 2021

O artigo apresenta uma discussão sobre a construção da ciência a partir de uma reflexão sobre as denominadas “novas epistemologias” com ênfase na impossibilidade em pensar de modo linear os “avanços científicos”. Reflete-se criticamente sobre as noções de “paradigmas”, “neutralidade” e “universalidade”. A epistemologia é pensada como fora dos rígidos preceitos metodológicos. A discussão inclui referências à produção dos jornalistas. Breaking the chains: the production of knowledge in the face of other espistemologies AbstractThe article presents a discussion about the construction of science starting from a reflection about new epstemology with emphasis in the impossibility of linear thinking the scientific advances. It introduces a critical reflection about the notion of paradigms, neutrality and universality. The epistemology is thought outside the rigid methodological precepts. The discussion includes references to the journalists productions. Keywords: Science; epstemology; paradigms.
Active methodologies supported by interaction and communication technologies in higher education
Authors: Monica Cristina Garbin  , Edison Trombeta de Oliveira  , Telles Simone 
Published: December 2021

In the last decades, technologies have been adopted by Higher Education Institutions, all over the world, as tools to approach new pedagogical practices for their programs. This paper aims to present an experience on the use of tools for communication, interaction and collaboration in a project-based learning on distance education. The project is developed virtually, with students organized in groups in order to develop a solution to a real problem. Therefore, with the use of technology, it is intended to provide those involved with forms of communication and interaction. Technologies in a context like this are considered strong allies of the teaching process developed under the perspective of collaborative work and the development of student autonomy. The collected data show results that indicate the used tools have promoted collaboration between the students, who have learned by developing solutions to problems.
Keywords: Higher education; distance education; collaborative learning.
Analysing students’ college english test-band 4(CET-4) scores based on educational data mining
Authors: Ji Ruixuan 
Published: December 2021

There is a large amount of data accumulated in management systems in universities and information hidden in these large amounts of data is not fully tapped and applied. Using data mining techniques in education research can help in the extraction of many valuable patterns from the data. The purpose of this article is to analyze the linear relation between the students’ total score of College English Test-Band 4 (CET-4) and scores in each part of the test, using Support vector machin.e (SVM) to classify students' CET-4 performance in each part. The research collected data with questionnaires and analysis was carried out with the help of SPSS. The result showed that the main factors that affect the CET-4 results are previous experience of learning English, attitudes toward the test and time spent on learning English per day.

Keywords: CET-4 score; Educational data mining; SVM classification; Influence factors
Tekst prasowy jako bodziec do interakcji na lekcji języka obcego
Authors: Płowens Jakub 
Published: December 2021

The paper shows how press text enables the development of interaction as a kind of interesting stimulus which motivates speaking. There were given characteristics of different genres of press text which have their aims in communication. Glottodidactic potential reveal title and lead as well as the body of text. The idea to imply press text for interaction was described. Attention was paid to what learners gain from both reading press text and speaking about its content. Moreover, instructions to a teacher were determined. The role of a teacher who can maintain the speaking action in the classroom was emphasized.
Sądowoadministracyjna kontrola przyjęć na studia w PRL
Authors: Kiczka Karol 
Published: December 2021

The scope of judicial review regarding the application of administrative law in the authoritarian Polish People’s Republic (Polska Rzeczpospolita Ludowa — PRL) was limited. The reason for this is obvious: resolving disputes between executive power (public administration) and individuals in PRL by courts functioning in honest and effective way would be an “obstruction” of the tasks executed by the communist state. The Supreme Administrative Court was reactivated in the last stage of PRL’s functioning in 1980, following the model of interwar tradition. The paper offers an analysis of judicial-administrative review in PRL in the field of university admissions.
Organization and functioning of the authoritarian PRL exerted an influence on the way judicial review of public administration operated. Administrative justice reactivated in 1980 was submitted to organizational and jurisdictional limitations, as the created Supreme Administrative Court was a one-instance institution with limited jurisdiction, filled with only nine judges. Still, reactivating administrative justice began the process of restoring the proper place for freedoms and individual rights against the state, including the right to attend higher education schools.
The analysis of the chosen case has allowed to identify some significant interconnected processes and phenomena in the judicial-administrative review in the declining stage of PRL within the whole domain of administrative law. One example is public administration striving for avoiding judicial review by taking a position that settlement of an administrative matter by the university is not an administrative decision. Another example is regulation of individual freedoms and rights by a multi-layered unstable system of legal sources, including: law on higher education, order of the Minister for Science, Higher Education and Technology, and non-published guidelines from the Minister of Health and Social Welfare of 21 May 1981 on admission principles and procedure of full-time studies at medical universities.
"DE REPENTE OUVI OS GRITOS"
Authors: Rodrigues Soares Santos Bruno 
Published: December 2021

Durante a década que vai de 1960 a 1980 o Brasil sofreu abusos com o autoritarismo e as duras regras do regime militar brasileiro, responsável por deixar grandes cicatrizes que permeiam as vítimas até os dias de hoje, e que surge na literatura, como uma crítica a censura e a repressão instaurada naquele período. O presente trabalho teve como objetivo geral uma análise do conto “Recordações do Casarão”, de Bernardo Kucinski, que traz em sua estrutura narrativa a memória e os traumas de alguns personagens acerca da ditadura militar. A utilização de uma linguagem subjetiva, a escolha de um tema descrito e exposto subliminarmente, ainda que não choque o leitor em uma primeira leitura considerada na época menos “engajada politicamente” do que narrativas que optem por uma visão mais realistas da violência do Estado, esta obra, possui um efeito surpreendente. Trata-se de uma abordagem que tenta explicitar eventos ocorridos na época. É fato que este momento dentro da história nacional, trouxe consigo diversos sentimentos e críticas sociais e é por isso que este tema se justifica.
PROBLEM-SOLVING EXPERIENCE WHEN OPENING NOBLE GYMNASIUMS’ BOARDING HOUSES IN THE KYIV EDUCATIONAL DISCTRICT CURATOR’S COUNCIL ACTIVITIES
Authors: Balatsynova Alla 
Published: December 2021

based on regulatory and archival documents analysis, the article considers the problem-solving experience when opening noble gymnasiums’ boarding schools in the Kiev educational district curator’s council activities. The Council’s position on this issue, the procedure for making and executing its decisions are clarified on the example of opening the second boarding school at the first Kiev gymnasium in 1836. Thoroughly analysing the state of affairs of the already-performing noble boarding school at the first Kiev gymnasium, Kiev educational district curator’s council members came to the conclusion that one more boarding school opening was necessary. They either approved of the staff developed by the educational district curator, and made proposals on sources of its initial arrangement funding.
It is established that the opinion of Kiev educational district curator’s council regarding the second noble boarding school opening at the first Kyiv gymnasium was taken into account by the Ministry of public education when making the final decision.
Method of analysis of the current state of inertial characteristics of an autonomous mobile robot of variable configuration
Authors: Koshevoy Nicolay , Ashepkova Natalja , Luchko Andrii 
Published: December 2021

The features of the dynamics of an autonomous mobile robot (AMR) of variable configuration with the relative movement of attachments are considered. Analysis of the current state of inertial characteristics during AMR operation will ensure stable movement along a given trajectory, successful implementation of technological operations by attachments, and preservation of the robot's functionality when operating under undetermined or extreme conditions. At the design stage, the analysis of the inertial characteristics of the AMR will make it possible to refine the parameters of the mathematical model, improve the algorithms for adaptive control and correct the commands for the actuators. Figs.: 2. Tabl.: 2. Bibliogr.: 10 titles.
Keywords: autonomous mobile robot, inertial characteristics.
In silico and in vitro analysis of recombinant arginine deiminase from Pseudomonas furukawaii as a potential anticancer enzyme
Authors: Dhankhar Rakhi , Gupta Vatika , Mohanty Aparajita , Gulati Pooja 
Published: December 2021

Abstract
Arginine deiminase (ADI) is a promising anticancer enzyme that can be employed in amino acid deprivation therapy for the treatment of various arginine auxotrophic tumors. In our previous work, Pseudomonas furukawaii was identified as a potent producer of ADI with optimum activity at physiological pH and temperature. The 3D structure of PfADI was modeled. Immunoinformatics analysis was also carried out to compare the immunogenicity of PfADI with MhADI (Mycoplasma hominis ADI, which is in phase III clinical trials). The PfADI was found to be less immunogenic in terms of number of linear and conformational B cell epitopes and T cell epitope density. The overall antigenicity and allergenicity of PfADI was also lower as compared to MhADI. Thus, the ADI coding arcA gene was cloned and expressed in E. coli BL21. Recombinant ADI of P. furukawaii (PfADI) was purified using affinity chromatography and its molecular mass was estimated to be ~46KDa. PfADI was found to effectively inhibit the HepG2 cells with an IC50 value of 0.1950 IU/ml. PfADI was characterized and the enzyme was found to be stable at human physiological conditions (pH 7 and 37 ⁰C temperature). The Km and Vmax values were found to be 1.90 mM and 1.83 µmol ml-1min-1 respectively. Thus the present in vitro and in silico studies establish PfADI as a potential anticancer drug candidate with improved efficacy and low immunogenicity.
Accurate Impressive Optical Solitons For Nonlinear Refractive Index Cubic-Quartic through Birefringent Fibers
Authors: Zahran Emad H.M. , Bekir Ahmet 
Published: December 2021

Abstract
The main target of this work implements new accurate impressive optical solitons for four forms of the nonlinear refractive index cubic-quartic through birefringent fibers which play a vital role in all modern telecommunications process. These four different forms listed under whose profile names which are the cubic-quartic in polarization-preserving fibers with its different forms which are the kerr-law, the quadratic-law, the parabolic-law and the non-local-law NLSE. These new accurate optical solitons for these different forms are extracted in the framework of the solitary wave ansatz method (SWAM) which is powerful technique that achieves accurate results for all problems that are solved in the framework of it. The achieved results will be compared by the previous results which are achieved via other authors.
Energy Consumption Delay Evaluation of NB-IoT Terminal Based on Markov Model
Authors: Xie Tairong , Zhang Xianyong , Liu Jun 
Published: December 2021

Abstract
The energy consumption of terminal of Internet of Things has attracted much attention in the study of smart Internet of Things. How to simulate the energy consumption process of the terminal from the theoretical level, so as to analyze the energy consumption and delay of the terminal are important issues. In this paper, taking the power monitoring terminal as an example, a Markov model is established for the Narrow-Band Internet of Things (NB-IoT) terminal with periodic automatic reporting. The working state of the terminal includes PSM (Power Saving Mode), random access (RACH), data transport and receive (Tx/Rx), short eDRX (Extended Discontinuous Reception), long eDRX and terminal disconnection (ERROR). According to the proposed model, the effects of network quality, maximum possible number of RACH request times (Rmax ) and data retransmission times (N1, N2) on terminal energy consumption and delay are analyzed. The numerical results show that network quality, maximum number of random access and maximum number of data retransmission directly affect the energy consumption and service quality of the terminal. Reasonable configuration of the above indicators can effectively improve the service life of the terminal and meet the customer’s requirements for the terminal service quality under the condition of maximum power saving. The model provides a reference for energy consumption and delay optimization of NB-IoT terminal.
Prevalence and Patterns of EGFR Mutations in Non-Small Cell Lung Cancer in the Middle East and North Africa: A Systematic Review
Authors: Boustany Youssra , Laraqui Abdelilah , Rhaffouli Hicham El , Bajjou Tahar , Mchichi Bouchra El , Anaz Hicham El , Amine Idriss Lahlou , Chahdi Hafsa , Oukabli Mohammed , Souhi Hicham , Ouazzani Hanane El , Rhorfi Ismail Abderrahmani , Abid Ahmed , Mahfoud Tarik , Tanz Rachid , Ichou Mohammed , Ennibi Khaled , Belkadi Bouchra , Sekhsokh Yassine 
Published: December 2021

Abstract
To summarize current evidence and estimate the prevalence of epidermal growth factor receptor (EGFR) mutation frequency and its association with ethnicity and clinic-pathological features in non-small cell lung cancer (NSCLC) patients in the Middle East (ME) and North Africa (NA), a systematic literature review was undertaken. We conducted a literature search of original articles published in six databases (PubMed, Science Direct, Web of Science, Embase, Scopus, and Google scholar) from the time of inception until April 2021. Search terms included “lung cancer”, “NSCLC”, “EGFR mutation”, “Middle East”, “North Africa”, and specific country names belonging to the considered region. The included studies had to meet the following criteria: the study must relate to the role of the EGFR gene in NSCLC, analyze mutations in exon 18, 19, 20, and 21 or select exons of the EGFR gene, and provide sufficient information on the clinic-pathological characteristics of the included NSCLC patients. A total of 24 eligible studies were included [(66.6%) in the ME and (34.4%) in NA]. Overall, 6544 patients with NSCLC were analyzed for EGFR mutations [(55.1%) in the ME and (44.8%) in NA]. The overall prevalence of EGFR mutations was 17.9%. In the ME, the reported frequency was 17.3%, whereas in NA, the prevalence of EGFR mutations was 18.5%. The most frequently encountered mutations were the exon 19 deletions (45.2%) and exon 21 substitutions (30.9%). Exon 20 alterations were detected in 11.2%, of which, the T790M resistance mutation was the most prevalent (45.5%). Exon 18 mutations were reported in 3.8%. In the ME, 50.5% of NSCLC patients were positive for exon 19 deletions versus 48.3% in NA. Exon 21 mutations were slightly more commonly detected in the ME (36.3%) than NA (31.3%). There was 1.2% of patients that had concurrent EGFR mutations. Overall, EGFR mutations prevalence was higher in females, non-smokers, and patients with adenocarcinoma. Our systematic literature review concurs that EGFR mutation prevalence among MENA populations is slightly higher than that seen in NSCLC patients of Caucasian ethnicity but is lower than that identified in Asian NSCLC patients. The distribution of these mutations varies significantly throughout the MENA region.
Single-Base Resolution Methylomes of Somatic Embryogenesis in Theobroma Cacao L. Reveal Epigenome Modifications Associated With Somatic Embryo Abnormalities
Authors: Garcia Claudia , de Almeida Alex-Alan Furtado , Costa Marcio , Britto Dahyana , Correa Fabio , Mangabeira Pedro , Silva Lidiane , Silva Jose , Royaert Stefan , Marelli Jean-Philippe 
Published: December 2021

Abstract
Propagation by somatic embryogenesis in Theobroma cacao has some issues to be solved, as many morphologically abnormal somatic embryos that do not germinate into plants are frequently observed, thus hampering plant production on a commercial scale. For the first time the methylome landscape of T. cacao somatic embryogenesis was examined, using whole-genome bisulfite sequencing technique, with the aim to understand the epigenetic basis of somatic embryo abnormalities. We identified 873 differentially methylated genes (DMGs) in the CpG context between zygotic embryos, normal and abnormal somatic embryos, with important roles in development, programmed cell death, oxidative stress, and hypoxia induction, which can help to explain the morphological abnormalities of somatic embryos. We also identified the role of ethylene and its precursor 1-aminocyclopropane-1-carboxylate in several biological processes, such as hypoxia induction, cell differentiation and cell polarity, that could be associated to the development of abnormal somatic embryos. The biological processes and the hypothesis of ethylene and its precursor involvement in the somatic embryo abnormalities in cacao are discussed.
Accuracy, Precision, And Agreement Statistical Tests For Bland-Altman Method
Authors: Silveira Paulo S.P. , Vieira Joaquim E. , Ferraro Alexandre A. , Siqueira Jose O. 
Published: December 2021

Abstract
Background: Bland and Altman plot method is a widely cited graphical approach to assess equivalence of quantitative measurement techniques. Perhaps due to its graphical output, it has been widely applied, however often misinterpreted by lacking of inferential statistical support. To compare data sets obtained from two measurement techniques, researchers may apply Pearson’s correlation, ordinal least-square linear regression, or the Bland-Altman plot methods, failing to locate the weakness of each measurement technique. We aim to develop and distribute a statistical method in R in order to add robust and suitable inferential statistics of equivalence. Methods: Three nested tests based on structural regressions are proposed to assess the equivalence of structural means (accuracy), equivalence of structural variances (precision), and concordance with the structural bisector line (agreement in measurements of data pairs obtained from the same subject) to reach statistical support for the equivalence of measurement techniques. Graphical outputs illustrating these three tests were added to follow Bland and Altman’s principles of easy communication. Results: Statistical p-values and robust approach by bootstrapping with corresponding graphs provide objective, robust measures of equivalence. Five pairs of data sets were analyzed in order to criticize previously published articles that applied the Bland and Altman’s principles, thus showing the suitability of the present statistical approach. In one case it was demonstrated strict equivalence, three cases showed partial equivalence, and one case showed poor equivalence. Package containing open codes and data is available with installation instructions on SourceForge for free distribution. Conclusions: Statistical p-values and robust approach assess the equivalence of accuracy, precision, and agreement for measurement techniques. Decomposition in three tests helps the location of any disagreement as a means to fix a new technique.
Clinical Outcomes in Locally Advanced Prostate Cancer Between Radical Prostatectomy and Radiotherapy With Androgen Deprivation Therapy: A Propensity Score-matched Analysis
Authors: Lu Yu-Cheng , Huang Chao-Yuan , Cheng Chia-Hsien , Huang Kuo-How , Lu Yu-Chuan , Chow Po-Ming , Chang Yi-Kai , Pu Yeong-Shiau , Chen Chung-Hsin , Lu Shao-Lun , Lan Keng-Hsueh , Chen Pei-Ling , Hong Jian-Hua 
Published: December 2021

Abstract
To compare clinical outcomes between the use of robotic-assisted laparoscopic radical prostatectomy (RP) and radiotherapy (RT) with long-term androgen deprivation therapy (ADT) in locally advanced prostate cancer (PC), we enrolled 315 patients with locally advanced PC (clinical T-stage 3/4). Propensity score-matching at a 1:1 ratio was performed. The median follow-up period was 59.2 months (IQR: 39.8-87.4). There were 117 (37.1%) patients in the RP group and 198 (62.9%) patients in the RT group. RT patients were older and had higher PSA at diagnosis, higher Gleason score grade group and more advanced T-stage (all p<0.001). After propensity score-matching, there were 68 patients in each group. Among locally advanced PC patients, treatment with RP had a higher risk of biochemical recurrence compared to the RT group. In multivariate Cox regression analysis, treatment with RT plus ADT significantly decreased the risk of biochemical failure (HR: 0.162, p<0.001), but there was no significant difference in local recurrence, distant metastasis and overall survival (p=0.470, p=0.268 and p=0.509, respectively). This information may provide insight for clinicians and patients for decision-making regarding their preference for either treatment strategy.