bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Stratigraphy and Loading History in Generating Complex Compaction Bands in Idealized Field‐Scale Settings
Authors: Shahin Ghassan , Torabi Anita , Rudnicki John , Buscarnera Giuseppe 
Published: January 2021

AbstractThe Buckskin Gulch locality in Utah is a landmark example of compaction localization. The outcrop of this locality involves distinct stratigraphic heterogeneity and was exposed to complex loading history. It features multiple sets of deformation bands with different kinematics and orientation. Similar formations were seen in the Valley of Fire, Nevada, and the Orange quarry, France, among other localities. The formation of such complex structures, their propagation mechanisms, and frequency is affected by numerous local and ambient factors whose impacts are not yet fully understood. The simulation of the above‐mentioned localities is not feasible because of the limited amount of available information. This work, instead, investigates from a geomechanics standpoint how the interplay among material nonlinearity, outcrop stratigraphy, and loading history interconnects with specific spatiotemporal patterns of compaction band propagation. Our study shows that the system stratigraphy can be responsible for the emergence of coexisting compaction bands with different inclination and kinematics. Specifically, we show that stiffness contrasts induce nonlocal stress changes which may favor the initiation of secondary structures with different compaction localization characteristics. Furthermore, systems of inclined compaction bands induced by burial increase display secondary, noncontemporaneous sets of vertical compaction bands under the effects of postburial shortening. Our results indicate that stages of intermediate burial decrease prior to tectonic shortening can promote the formation of such complex systems. Despite the simplifications involved in our analyses, these findings show how geomechanics computations complement field observations and could provide a mechanics‐based validation of site‐specific reconstruction hypothesis.
Establishing a clinical service to prevent psychosis: What, how and when? Systematic review
Authors: Salazar de Pablo Gonzalo , Estradé Andrés , Cutroni Marcello , Andlauer Olivier , Fusar-Poli Paolo 
Published: January 2021

AbstractThe first rate-limiting step to successfully translate prevention of psychosis in to clinical practice is to establish specialised Clinical High Risk for Psychosis (CHR-P) services. This study systematises the knowledge regarding CHR-P services and provides guidelines for translational implementation. We conducted a PRISMA/MOOSE-compliant (PROSPERO-CRD42020163640) systematic review of Web of Science to identify studies until 4/05/2020 reporting on CHR-P service configuration, outreach strategy and referrals, service user characteristics, interventions, and outcomes. Fifty-six studies (1998–2020) were included, encompassing 51 distinct CHR-P services across 15 countries and a catchment area of 17,252,666 people. Most services (80.4%) consisted of integrated multidisciplinary teams taking care of CHR-P and other patients. Outreach encompassed active (up to 97.6%) or passive (up to 63.4%) approaches: referrals came mostly (90%) from healthcare agencies. CHR-P individuals were more frequently males (57.2%). Most (70.6%) services accepted individuals aged 12–35 years, typically assessed with the CAARMS/SIPS (83.7%). Baseline comorbid mental conditions were reported in two-third (69.5%) of cases, and unemployment in one third (36.6%). Most services provided up to 2-years (72.4%), of clinical monitoring (100%), psychoeducation (81.1%), psychosocial support (73%), family interventions (73%), individual (67.6%) and group (18.9%) psychotherapy, physical health interventions (37.8%), antipsychotics (87.1%), antidepressants (74.2%), anxiolytics (51.6%), and mood stabilisers (38.7%). Outcomes were more frequently ascertained clinically (93.0%) and included: persistence of symptoms/comorbidities (67.4%), transition to psychosis (53.5%), and functional status (48.8%). We provide ten practical recommendations for implementation of CHR-P services. Health service knowledge summarised by the current study will facilitate translational efforts for implementation of CHR-P services worldwide.
Emerging behavioral and neuroimaging biomarkers for early and accurate characterization of autism spectrum disorders: a systematic review
Authors: Hiremath Chandrakanta S. , Sagar Kommu John Vijay , Yamini B. K. , Girimaji Akhila S. , Kumar Raghavendra , Sravanti Sanivarapu Lakshmi , Padmanabha Hansashree , Vykunta Raju K. N. , Kishore M. Thomas , Jacob Preeti , Saini Jitender , Bharath Rose D. , Seshadri Shekhar P. , Kumar Manoj 
Published: January 2021

AbstractThe possibility of early treatment and a better outcome is the direct product of early identification and characterization of any pathological condition. Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in social communication, restricted, and repetitive patterns of behavior. In recent times, various tools and methods have been developed for the early identification and characterization of ASD features as early as 6 months of age. Thorough and exhaustive research has been done to identify biomarkers in ASD using noninvasive neuroimaging and various molecular methods. By employing advanced assessment tools such as MRI and behavioral assessment methods for accurate characterization of the ASD features and may facilitate pre-emptive interventional and targeted therapy programs. However, the application of advanced quantitative MRI methods is still confined to investigational/laboratory settings, and the clinical implication of these imaging methods in personalized medicine is still in infancy. Longitudinal research studies in neurodevelopmental disorders are the need of the hour for accurate characterization of brain–behavioral changes that could be monitored over a period of time. These findings would be more reliable and consistent with translating into the clinics. This review article aims to focus on the recent advancement of early biomarkers for the characterization of ASD features at a younger age using behavioral and quantitative MRI methods.
Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis
Authors: Küper Alina , Baumann Jennifer , Göpelt Kirsten , Baumann Melanie , Sänger Christopher , Metzen Eric , Kranz Philip , Brockmeier Ulf 
Published: January 2021

AbstractHypoxia-induced resistance of tumor cells to therapeutic treatment is an unresolved limitation due to poor vascular accessibility and protective cell adaptations provided by a network, including PERK, NRF2, and HIF signaling. All three pathways have been shown to influence each other, but a detailed picture remains elusive. To explore this crosstalk in the context of tumor therapy, we generated human cancer cell lines of pancreatic and lung origin carrying an inducible shRNA against NRF2 and PERK. We report that PERK-related phosphorylation of NRF2 is only critical in Keap1 wildtype cells to escape its degradation, but shows no direct effect on nuclear import or transcriptional activity of NRF2. We could further show that NRF2 is paramount for proliferation, ROS elimination, and radioprotection under constant hypoxia (1% O2), but is dispensable under normoxic conditions or after reoxygenation. Depletion of NRF2 does not affect apoptosis, cell cycle progression and proliferation factors AKT and c-Myc, but eliminates cellular HIF-1α signaling. Co-IP experiments revealed a protein interaction between NRF2 and HIF-1α and strongly suggest NRF2 as one of the cellular key factor for the HIF pathway. Together these data provide new insights on the complex role of the PERK-NRF2-HIF-axis for cancer growth.
Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy
Authors: Gromeier Matthias , Brown Michael C. , Zhang Gao , Lin Xiang , Chen Yeqing , Wei Zhi , Beaubier Nike , Yan Hai , He Yiping , Desjardins Annick , Herndon James E. , Varn Frederick S. , Verhaak Roel G. , Zhao Junfei , Bolognesi Dani P. , Friedman Allan H. , Friedman Henry S. , McSherry Frances , Muscat Andrea M. , Lipp Eric S. , Nair Smita K. , Khasraw Mustafa , Peters Katherine B. , Randazzo Dina , Sampson John H. , McLendon Roger E. , Bigner Darell D. , Ashley David M. 
Published: January 2021

AbstractSeveral immunotherapy clinical trials in recurrent glioblastoma have reported long-term survival benefits in 10–20% of patients. Here we perform genomic analysis of tumor tissue from recurrent WHO grade IV glioblastoma patients acquired prior to immunotherapy intervention. We report that very low tumor mutation burden is associated with longer survival after recombinant polio virotherapy or after immune checkpoint blockade in recurrent glioblastoma patients. A relationship between tumor mutation burden and survival is not observed in cohorts of immunotherapy naïve newly diagnosed or recurrent glioblastoma patients. Transcriptomic analyses reveal an inverse relationship between tumor mutation burden and enrichment of inflammatory gene signatures in cohorts of recurrent, but not newly diagnosed glioblastoma tumors, implying that a relationship between tumor mutation burden and tumor-intrinsic inflammation evolves upon recurrence.
Genome-wide macroevolutionary signatures of key innovations in butterflies colonizing new host plants
Authors: Allio Rémi , Nabholz Benoit , Wanke Stefan , Chomicki Guillaume , Pérez-Escobar Oscar A. , Cotton Adam M. , Clamens Anne-Laure , Kergoat Gaël J. , Sperling Felix A. H. , Condamine Fabien L. 
Published: January 2021

AbstractThe mega-diversity of herbivorous insects is attributed to their co-evolutionary associations with plants. Despite abundant studies on insect-plant interactions, we do not know whether host-plant shifts have impacted both genomic adaptation and species diversification over geological times. We show that the antagonistic insect-plant interaction between swallowtail butterflies and the highly toxic birthworts began 55 million years ago in Beringia, followed by several major ancient host-plant shifts. This evolutionary framework provides a valuable opportunity for repeated tests of genomic signatures of macroevolutionary changes and estimation of diversification rates across their phylogeny. We find that host-plant shifts in butterflies are associated with both genome-wide adaptive molecular evolution (more genes under positive selection) and repeated bursts of speciation rates, contributing to an increase in global diversification through time. Our study links ecological changes, genome-wide adaptations and macroevolutionary consequences, lending support to the importance of ecological interactions as evolutionary drivers over long time periods.
Ontological modeling and analysis of experimentally or clinically verified drugs against coronavirus infection
Authors: Liu Yingtong , Hur Junguk , Chan Wallace K. B. , Wang Zhigang , Xie Jiangan , Sun Duxin , Handelman Samuel , Sexton Jonathan , Yu Hong , He Yongqun 
Published: January 2021

AbstractOur systematic literature collection and annotation identified 106 chemical drugs and 31 antibodies effective against the infection of at least one human coronavirus (including SARS-CoV, SAR-CoV-2, and MERS-CoV) in vitro or in vivo in an experimental or clinical setting. A total of 163 drug protein targets were identified, and 125 biological processes involving the drug targets were significantly enriched based on a Gene Ontology (GO) enrichment analysis. The Coronavirus Infectious Disease Ontology (CIDO) was used as an ontological platform to represent the anti-coronaviral drugs, chemical compounds, drug targets, biological processes, viruses, and the relations among these entities. In addition to new term generation, CIDO also adopted various terms from existing ontologies and developed new relations and axioms to semantically represent our annotated knowledge. The CIDO knowledgebase was systematically analyzed for scientific insights. To support rational drug design, a “Host-coronavirus interaction (HCI) checkpoint cocktail” strategy was proposed to interrupt the important checkpoints in the dynamic HCI network, and ontologies would greatly support the design process with interoperable knowledge representation and reasoning.
Quality of Pinus sp. pellets with kraft lignin and starch addition
Authors: Surdi de Castro Paula Gabriella , de Siqueira Humberto Fauller , de Castro Vinícius Resende , Zanuncio Antônio José Vinha , Zanuncio José Cola , Berger Matheus da Silva , Martins Francisco Damião Rodrigues , Carneiro Angélica de Cássia Oliveira , Gominho Jorge , de Oliveira Araújo Solange 
Published: January 2021

AbstractPellets are widely used for power generation because they use renewable raw material with easy storage, transport and high energy density. However, the structural fragility, disintegrating during handling, transport and storage, is one of the main problems of pellets, but the addition of binders/additives can minimize this fragility. The objective of this study was to evaluate the properties of wood pellets with the addition of starch (corn and wheat) and kraft lignin in different proportions. Pellets were produced with the addition of starch (wheat and corn) and kraft lignin in the proportions of 1, 2, 3, 4 and 5% in relation to the mass of wood particles of Pinus sp., with 12% moisture (dry basis), classified in 3 and 1 mm sieves and compacted in a pelleting press in the laboratory, according to European standard EN 14961-2. Physical and mechanical properties of the pellets were evaluated and their densitometric profiles obtained from the Faxitron LX-60 X-ray equipment. Corn starch and kraft lignin additives at 4% improved pellet properties (density, fines and hardness), reducing their losses during handling, storage and transport.
Fixational eye movements abnormalities and rate of visual acuity and stereoacuity improvement with part time patching
Authors: Scaramuzzi Matteo , Murray Jordan , Nucci Paolo , Shaikh Aasef G. , Ghasia Fatema F. 
Published: January 2021

AbstractResidual amblyopia is seen in 40% of amblyopic patients treated with part-time patching. Amblyopic patients with infantile onset strabismus or anisometropia can develop fusion maldevelopment nystagmus syndrome (FMNS). The purpose of this study was to understand the effects of presence of FMNS and clinical subtype of amblyopia on visual acuity and stereo-acuity improvement in children treated with part-time patching. Forty amblyopic children who had fixation eye movement recordings and at least 12 months of follow-up after initiating part-time patching were included. We classified amblyopic subjects per the fixational eye movements characteristics into those without any nystagmus, those with FMNS and patients with nystagmus without any structural anomalies that do not meet the criteria of FMNS or idiopathic infantile nystagmus. We also classified the patients per the clinical type of amblyopia. Patching was continued until amblyopia was resolved or no visual acuity improvement was noted at two consecutive visits. Children with anisometropic amblyopia and without FMNS have a faster improvement and plateaued sooner. Regression was only seen in patients with strabismic/mixed amblyopia particularly those with FMNS. Patients with FMNS had improvement in visual acuity but poor stereopsis with part-time patching and required longer duration of treatment.
Uncovering dynamic evolution in the plastid genome of seven Ligusticum species provides insights into species discrimination and phylogenetic implications
Authors: Yuan Can , Sha Xiufen , Xiong Miao , Zhong Wenjuan , Wei Yu , Li Mingqian , Tao Shan , Mou Fangsheng , Peng Fang , Zhang Chao 
Published: January 2021

AbstractLigusticum L., one of the largest members in Apiaceae, encompasses medicinally important plants, the taxonomic statuses of which have been proved to be difficult to resolve. In the current study, the complete chloroplast genomes of seven crucial plants of the best-known herbs in Ligusticum were presented. The seven genomes ranged from 148,275 to 148,564 bp in length with a highly conserved gene content, gene order and genomic arrangement. A shared dramatic decrease in genome size resulted from a lineage-specific inverted repeat (IR) contraction, which could potentially be a promising diagnostic character for taxonomic investigation of Ligusticum, was discovered, without affecting the synonymous rate. Although a higher variability was uncovered in hotspot divergence regions that were unevenly distributed across the chloroplast genome, a concatenated strategy for rapid species identification was proposed because separate fragments inadequately provided variation for fine resolution. Phylogenetic inference using plastid genome-scale data produced a concordant topology receiving a robust support value, which revealed that L. chuanxiong had a closer relationship with L. jeholense than L. sinense, and L. sinense cv. Fuxiong had a closer relationship to L. sinense than L. chuanxiong, for the first time. Our results not only furnish concrete evidence for clarifying Ligusticum taxonomy but also provide a solid foundation for further pharmaphylogenetic investigation.
Hydrogen peroxide modification affects the structure and physicochemical properties of dietary fibers from white turnip (Brassica Rapa L.)
Authors: Gao Qi , Zhou Xue-jie , Ma Rui , Lin Han , Wu Jia-le , Peng Xue , Tanokura Masaru , Xue You-lin 
Published: January 2021

AbstractTurnip (Brassica rapa L.) is widely consumed as a vegetable and traditional Chinese medicine with high dietary fiber content. Soluble dietary fiber (SDF) and insoluble dietary fiber (IDF) were obtained from white turnips, and the IDF was modified with alkaline hydrogen peroxide to obtain modified IDF (MIDF) and modified SDF (MSDF). The compositional, structural, and functional properties of the four samples were investigated. After modification, the modified dietary fibers (MDFs) showed smaller particle sizes and lower contents of pectin and polyphenol than those of unmodified dietary fibers (DFs) The results of scanning electron microscopy (SEM), Fourier transformed infrared (FT-IR) spectroscopy, X-ray diffraction (XRD) and differential scanning calorimetry (DSC) showed that compared to the DFs, the MDFs were smaller and had more exposed hydroxyl groups. Analysis of the microrheological behaviors showed that the MDFs had higher viscosity than that of the DFs, with a looser structure for the MSDF and a stable structure for the MIDF. Therefore, due to structural changes, the physical and functional properties of the MDFs were improved compared to those of the unmodified DFs. Pearson correlation analysis showed that the particle size was positively correlated with the pectin content. The water holding capacity (WHC), oil adsorption capacity (OAC) and water swelling capacity (WSC) showed positive correlations with each other. This work indicated that white turnip could be a potential new source of DFs, which presented desirable functional properties after modification.
Time to fiddle with your unpublished data
Authors: Ryan Michael J. , Touyz Rhian M. 
Published: January 2021

Abstract
Most scientific investigators conduct well-designed and controlled preclinical experiments generating data that are difficult to explain, contrast with existing scientific dogma, or represent a perceived negative result. It is common for these findings to remain hidden away in a drawer from the greater scientific community. However, these unseen results can lead to publication bias, have the potential to significantly advance scientific disciplines if they are published, and can help investigators avoid repeating experiments that have already been done, thus saving money and time. Moreover, these unexpected data may actually have significance if re-interpreted leading to new hypotheses. This editorial commentary highlights a novel user-friendly tool developed by Bernard and colleagues (Clin Sci (Lond) (2020) 134 (20): 2729–2739) to help investigators determine appropriate options for disseminating unpublished data in order to make them available to the broader scientific community. In addition, this commentary serves as an announcement for an upcoming special call for papers on meta-research to be published in Clinical Science. Meta-research is the evaluation and study of existing scientific literature and data. It is an evolving field dedicated to improving rigor and reproducibility in science, an endeavor to which Clinical Science and Portland Press are committed.
Novel system model‐based fault location approach using dynamic search technique
Authors: Ananthan Sundaravaradan Navalpakkam , Bastos Alvaro Furlani , Santoso Surya 
Published: January 2021

AbstractImpedance‐based fault location (IBFL) approaches are the most commonly used fault location methods in digital relays. However, each IBFL approach is designed specific to a line or network configuration and thus is not universal. For example, complex line configurations such as lines with mutual coupling between them and three‐terminal lines have to employ individual IBFL algorithms derived specifically for them. Furthermore, they suffer from several sources of errors such as non‐homogeneous system, and CT saturation. Hence, this paper presents a novel fault location approach that utilises a system model to overcome these limitations. The proposed model‐based fault location (MBFL) approach estimates the fault location by identifying the closest match among various anticipated fault scenarios obtained using the system model and the actual fault scenario. It uses a dynamic search technique to implement the MBFL efficiently. A key highlight of the proposed approach is identifying the location of a fault on a neighbouring line using limited measurements, as few as only the through fault current flowing in a neighbouring line. The advantages of the approach and its practical applicability have been demonstrated by implementing it in complex network configurations as well as field data.
The Impact of the Global 2020 Health and Economic Crisis on the Consumption of Students Studying Macroeconomics
Authors: Dimitrova Boryana 
Published: January 2021

Research background: 2020 is the first year in recent human history with unprecedented closure of educational institutions and businesses for an extended period of time during the school year. The closure was not the result of military action, but of regulations aimed at stopping the spread of a disease, which at first glance seemed unusually dangerous. This required the learning and work processes to take place in people’s homes and not in the buildings of educational institutions and companies. It also affected the usual individuals’ consumption of goods. For the optimal recovery of the national and world economic and educational systems, it is necessary to have a variety of information about the impact of the crisis on different groups of the population.
Purpose of the article: This article aims to present the results of a study of changes in consumption, financial and employment status of students studying macroeconomics at a small Faculty of Economics in Southeast Europe.
Methods: The method of the self-administered survey, conducted through Google Forms, disseminated through closed Facebook groups, used for educational purposes, as well as direct sharing of links via Messenger, Viber and e-mail was used.
Findings & Value added: The changes in the expenses related to the consumption of key goods by the respondents, their financial and employment status have been identified and discussed. The accumulation of knowledge about living in times of crisis is discussed and the readiness of the respondents to purposefully study crisis management is established in view to the optimal formation of the human capital of the nation and the world.