bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Global Landscape of Treatment Standards for Breast Cancer
Authors: Trapani Dario , Douillard Jean Yves , Winer Eric P , Burstein Harold , Carey Lisa Anne , Cortes Javier , Lopes Gilberto , Gralow Julie R , Gradishar William J , Magrini Nicola , Curigliano Giuseppe , Ilbawi Andrè M 
Published: January 2021

Abstract

Background
Breast cancer (BC) is a leading cause of morbidity, mortality, and disability for women worldwide. There is substantial variation in treatment outcomes, which is function of multiple variables, including access to treatment. Treatment standards can promote quality and improve survival; thus, their development should be a priority for the cancer-control planning.

Methods
We extracted the guidelines for the treatment of BC from a systematic review of the literature. We evaluated the development process, the methodology, and the recommendations formulated and surveyed the country resource stratification. Metrics of health-system capacity were selected to study the guidelines context appropriateness.

Results
We analyzed 49 distinct guidelines for BC, mostly in English language (n = 23), developed in upper-middle and high-income countries of the European and American regions (n = 39). A resource-stratified approach was identified in a quarter of the guidelines (n = 11), mostly from resource-constrained settings. Only one-half of the guidelines reached a gender balance of the authorship, and 10.2% were based on a multidisciplinary steering committee. A number of efforts and solutions of resource adaptations were recognized, mostly in low- and middle-income countries. Overall, the national guidelines appeared not sensitive enough of the local health-system capacity in formulating recommendations, with possible exception for the radiation therapy availability.

Conclusion
This global landscape of treatment standards for BC demonstrates that the majority is not context appropriate. Research on the formulation of cancer treatment standards is highly warranted, along with novel platforms for developing and disseminating resource-appropriate guidance.
Distinct metabonomic signatures of Polygoni Multiflori Radix Praeparata against glucolipid metabolic disorders
Authors: Yang Ya-Qin , Meng Fan-Ying , Liu Xin , Zhang Mei , Gu Wen , Yan Hong-Li , Yu Jie , Yang Xing-Xin 
Published: January 2021

Abstract

Objectives
Glucolipid metabolic disorders (GLMD) promote a series of major chronic diseases. Polygoni Multilori Radix Preparata (PMRP) has been widely acknowledged in the prevention and treatment of GLMD. We previously reported that water extract (WE) of PMRP and its major bioactive constituents such as polysaccharides (POL) and 2,3,5,4´-tetrahydroxy-stilbene-2-O-β-D-glucoside (TSG) could alleviate GLMD. The mitochondrial dysfunction is an important mechanism of GLMD, but the underlying mechanisms behind the regulation of mitochondria to alleviate GLMD by WE, POL from PMRP and TSG are still unknown.

Methods
In this study, we elucidated the effects of WE, POL, and TSG towards regulating the mitochondrial dysfunction and alleviating GLMD using mitochondrial metabonomics. A rat model of GLMD was established by high-sugar and high-fat (HS-HF) diet. Rats were intragastrically given WE, POL, and TSG for 12 weeks. The liver mitochondrial metabolites were analyzed by ultra-high-performance liquid chromatography/mass spectrometry followed by multivariate statistical analysis to identify the differential metabolites and metabolic pathways.

Key findings
The WE, POL, and TSG could significantly restore the level of endogenous metabolites in liver mitochondria toward normal status. In total, sixteen, seven, and fourteen differential metabolites were identified in the liver mitochondrial samples obtained from the WE, GOL, and TSG groups, respectively. These metabolites were found to be mainly involved in glycerol phospholipid, histidine, alanine, aspartic acid, glutamate metabolism, and arginine biosynthesis.

Conclusions
PMRP could improve the liver mitochondrial function by regulating the mitochondrial metabolic pathways to alleviate GLMD. Therefore, the application of PMRP might be a promising mitochondrial regulator/nutrient for alleviating GLMD-associated diseases and the mitochondrial metabonomics might provide insights into the evaluation of the efficacies and mechanisms of action of drugs.
Two plastidic glycolate/glycerate translocator 1 isoforms function together to transport photorespiratory glycolate and glycerate in rice chloroplasts
Authors: Cui Lili , Zhang Chuanling , Li Zhichao , Xian Tuxiu , Wang Limin , Zhang Zhisheng , Zhu Guohui , Peng Xinxiang 
Published: January 2021

Abstract
The photorespiratory pathway is highly compartmentalized. As such, metabolite shuttles between organelles are critical to ensure efficient photorespiratory carbon flux. Arabidopsis plastidic glycolate/glycerate translocator 1 (PLGG1) has been reported as a key chloroplastic glycolate/glycerate transporter. Two homologous genes, OsPLGG1a and OsPLGG1b, have been identified in the rice genome, although their distinct functions and relationships remain unknown. Herein, our analysis of exogenous expression in oocytes and yeast shows that both OsPLGG1a and OsPLGG1b have the ability to transport glycolate and glycerate. Furthermore, we demonstrate in planta that the perturbation of OsPLGG1a or OsPLGG1b expression leads to extensive accumulation of photorespiratory metabolites, especially glycolate and glycerate. Under ambient CO2 conditions, loss-of-function osplgg1a or osplgg1b mutant plants exhibited significant decreases in photosynthesis efficiency, starch accumulation, plant height, and crop productivity. These morphological defects were almost entirely recovered when the mutant plants were grown under elevated CO2 conditions. In contrast to osplgg1a, osplgg1b mutant alleles produced a mild photorespiratory phenotype and had reduced accumulation of photorespiratory metabolites. Subcellular localization analysis showed that OsPLGG1a and OsPLGG1b are located in the inner and outer membranes of the chloroplast envelope, respectively. In vitro and in vivo experiments revealed that OsPLGG1a and OsPLGG1b have a direct interaction. Our results indicate that both OsPLGG1a and OsPLGG1b are chloroplastic glycolate/glycerate transporters required for photorespiratory metabolism and plant growth, and that they may function as a singular complex.
Resurrection plants optimize photosynthesis despite very thick cell walls by means of chloroplast distribution
Authors: Nadal Miquel , Perera-Castro Alicia V , Gulías Javier , Farrant Jill M , Flexas Jaume 
Published: January 2021

Abstract
Resurrection plants are vascular species able to sustain extreme desiccation in their vegetative tissues. Despite its potential interest, the role of leaf anatomy in CO2 diffusion and photosynthesis under non-stressed conditions has not been explored in these species. Net CO2 assimilation (An) and its underlying diffusive, biochemical, and anatomical determinants were assessed in 10 resurrection species from diverse locations, including ferns, and homoiochlorophyllous and poikilochlorophyllous angiosperms. Data obtained were compared with previously published results in desiccation-sensitive ferns and angiosperms. An in resurrection plants was mostly driven by mesophyll conductance to CO2 (gm) and limited by CO2 diffusion. Resurrection species had a greater cell wall thickness (Tcw) than desiccation-sensitive plants, a feature associated with limited CO2 diffusion in the mesophyll, but also greater chloroplast exposure to intercellular spaces (Sc), which usually leads to higher gm. This combination enabled a higher An per Tcw compared with desiccation-sensitive species. Resurrection species possess unusual anatomical features that could confer stress tolerance (thick cell walls) without compromising the photosynthetic capacity (high chloroplast exposure). This mechanism is particularly successful in resurrection ferns, which display higher photosynthesis than their desiccation-sensitive counterparts.
Incorporation of Whipstitch Suture in Tibial Interference Fixation Improves Pullout in Anterior Cruciate Ligament Soft Tissue Grafts
Authors: Bernstein Ethan , Taniguchi Kevin , Tompane Trevor , Kirby Hannah , Ponton Ryan , McDonald Lucas S 
Published: January 2021

ABSTRACT

Introduction
Interference screw fixation of soft tissue grafts is commonly used in anterior cruciate ligament (ACL) reconstruction. The purpose of this study was to determine whether including suture material at the graft–screw interface affects ultimate fixation strength of soft tissue grafts using a tibialis anterior tendon allograft model.

Materials and Methods
Forty fresh-frozen human tibialis anterior tendon allografts were fixed to rigid polyurethane foam simulating the tibial tunnel. Twenty grafts underwent fixation with interference screws and 20 with interference bolts. Within each group, 10 grafts had suture in contact with either the screw or bolt. A load-to-failure test was then performed at a rate of 200 mm/min.

Results
The group of allografts with sutures in the tibial tunnel had significantly higher load to failure than the group without sutures. Using interference screw fixation, failure load of the grafts without sutures in the tunnel (535.2 ± 73.40 N) was significantly lower (P = .001) than with sutures in the tunnel (696.3 ± 110.0 N). Using interference bolt fixation, failure load of the grafts without sutures in the tunnel (613.0 ± 83.46 N) was significantly lower (P &lt;.0001) than with sutures in the tunnel (845.8 ± 87.23 N).

Conclusions
In a biomechanical model, suture within the tibial tunnel enhances fixation strength with both interference screw and bolt fixation for soft tissue tibialis anterior allografts. Additionally, there was no difference in load to failure when comparing failure of a screw with suture in the tunnel with an interference bolt without suture. Due to improved biomechanical properties, incorporation of suture in the bone–graft interface should be considered when performing soft tissue ACL allograft reconstructions. Failure at the tibial bone–graft interface is a known complication of ACL reconstruction, and incorporation of suture within the interface should be considered for improved biomechanical properties.
Rank Offence: The Ecological Theory of Resentment
Authors: Reis-Dennis Samuel 
Published: January 2021

Abstract
I argue that fitting resentment tracks unacceptable ‘ecological’ imbalances in relative social strength between victims and perpetrators that arise from violations of legitimate moral expectations. It does not respond purely, or even primarily, to offenders’ attitudes, and its proper targets need not be fully developed moral agents. It characteristically involves a wish for the restoration of social equilibrium rather than a demand for moral recognition or good will. To illuminate these contentions, I focus on cases that I believe demonstrate a corollary thesis, namely, that strength, broadly construed, is a necessary condition of resentment-worthiness. I argue that weakness can make resentment unfitting in two ways. First, weakness may prevent a wrongdoer from shifting the balance of social power. Second, a weak wrongdoer may do social damage but be so lowly that resentment, which would represent him as excessively strong, would be inapt. Finally, I consider how accepting the ecological view might affect our theorizing about moral responsibility and the ethics of blame.
maxsmooth: rapid maximally smooth function fitting with applications in Global 21-cm cosmology
Authors: Bevins H T J , Handley W J , Fialkov A , de Lera Acedo E , Greenhill L J , Price D C 
Published: January 2021

ABSTRACTMaximally Smooth Functions (MSFs) are a form of constrained functions in which there are no inflection points or zero crossings in high-order derivatives. Consequently, they have applications to signal recovery in experiments where signals of interest are expected to be non-smooth features masked by larger smooth signals or foregrounds. They can also act as a powerful tool for diagnosing the presence of systematics. The constrained nature of MSFs makes fitting these functions a non-trivial task. We introduce maxsmooth, an open-source package that uses quadratic programming to rapidly fit MSFs. We demonstrate the efficiency and reliability of maxsmooth by comparison to commonly used fitting routines and show that we can reduce the fitting time by approximately two orders of magnitude. We introduce and implement with maxsmooth Partially Smooth Functions, which are useful for describing elements of non-smooth structure in foregrounds. This work has been motivated by the problem of foreground modelling in 21-cm cosmology. We discuss applications of maxsmooth to 21-cm cosmology and highlight this with examples using data from the Experiment to Detect the Global Epoch of Reionization Signature (EDGES) and the Large-aperture Experiment to Detect the Dark Ages (LEDA) experiments. We demonstrate the presence of a sinusoidal systematic in the EDGES data with a log-evidence difference of 86.19 ± 0.12 when compared to a pure foreground fit. MSFs are applied to data from LEDA for the first time in this paper and we identify the presence of sinusoidal systematics. maxsmooth is pip installable and available for download at https://github.com/htjb/maxsmooth.
A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage
Authors: Dong Chao , An Liwei , Yu Cheng-han , Huen Michael S Y 
Published: January 2021

Abstract
DNA double-strand breaks (DSBs) at ribosomal gene loci trigger inhibition of ribosomal DNA (rDNA) transcription and extensive nucleolar reorganization, including the formation of nucleolar caps where rDNA DSBs engage with canonical DSB signaling and repair factors. While these nucleolar responses underlie maintenance of rDNA stability, the molecular components that drive each of these events remain to be defined. Here we report that full suppression of rRNA synthesis requires the DYRK1B kinase, a nucleolar DSB response that can be uncoupled from ATM-mediated DSB signaling events at the nucleolar periphery. Indeed, by targeting DSBs onto rDNA arrays, we uncovered that chemical inhibition or genetic inactivation of DYRK1B led to sustained nucleolar transcription. Not only does DYRK1B exhibit robust nucleolar accumulation following laser micro-irradiation across cell nuclei, we further showed that DYRK1B is required for rDNA DSB repair and rDNA copy number maintenance, and that DYRK1B-inactivated cells are hypersensitised to DSBs induced at the rDNA arrays. Together, our findings not only identify DYRK1B as a key signaling intermediate that coordinates DSB repair and rDNA transcriptional activities, but also support the idea of specialised DSB responses that operate within the nucleolus to preserve rDNA integrity.
Preprocedural SARS-CoV-2 Testing to Sustain Medically Needed Health Care Delivery During the COVID-19 Pandemic: A Prospective Observational Study
Authors: Haidar Ghady , Ayres Ashley , King Wendy C , McDonald Mackenzie , Wells Alan , Mitchell Stephanie L , Bilderback Andrew L , Minnier Tami , Mellors John W 
Published: January 2021

Abstract

Background
We implemented a preprocedural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) screening initiative designed to sustain health care during a time when the extent of SARS-CoV-2 infection was unknown.

Methods
This was a prospective study of patients undergoing procedures at 3 academic hospitals in Pittsburgh, Pennsylvania (April 21–June 11), and 19 community hospitals across Middle/Western Pennsylvania and Southwestern New York (May 1–June 11). Patients at academic hospitals underwent symptom screening ≤7 days preprocedure, then SARS-CoV-2 nasopharyngeal polymerase chain reaction (PCR) testing 1–4 days preprocedure. A subset also underwent day-of-procedure testing. Community hospital patients underwent testing per local protocols. We report SARS-CoV-2 PCR positivity rates, impact, and barriers to testing encountered through June 11. PCR positivity rates of optional preprocedural SARS-CoV-2 testing for 2 consecutive periods following the screening initiative are also reported.

Results
Of 5881 eligible academic hospital patients, 2415 (41.1%) were tested (April 21–June 11). Lack of interest, distance, self-isolation, and nursing home/incarceration status were barriers. There were 11 PCR-positive patients (10 asymptomatic) among 10 539 patients tested (0.10%; 95% CI, 0.05%–0.19%): 3/2415 (0.12%; 95% CI, 0.02%–0.36%) and 8/8124 (0.10%; 95% CI, 0.04%–0.19%) at academic and community hospitals, respectively. Procedures were performed as scheduled in 40% (4/10) of asymptomatic PCR-positive patients. Positivity increased during subsequent coronavirus disease 2019 (COVID-19) surges: 54/34 948 (0.15%; 95% CI, 0.12%–0.20%) and 101/24 741 (0.41%; 95% CI, 0.33%–0.50%) PCR-positive patients from June 12–September 10 and September 11–December 15, respectively (P &lt; .0001).

Conclusions
Implementing preprocedural PCR testing was complex and revealed low infection rates (0.24% overall), which increased during COVID-19 surges. Additional studies are needed to define the COVID-19 prevalence threshold at which universal preprocedural screening is warranted.
Metabolic control of histone demethylase activity involved in plant response to high temperature
Authors: Cui Xiaoyun , Zheng Yu , Lu Yue , Issakidis-Bourguet Emmanuelle , Zhou Dao-Xiu 
Published: January 2021

Abstract
Jumonji C (JmjC) domain proteins are histone lysine demethylases that require ferrous iron and alpha-ketoglutarate (or α-KG) as cofactors in the oxidative demethylation reaction. In plants, α-KG is produced by isocitrate dehydrogenases (ICDHs) in different metabolic pathways. It remains unclear whether fluctuation of α-KG levels affects JmjC demethylase activity and epigenetic regulation of plant gene expression. In this work, we studied the impact of loss of function of the cytosolic ICDH (cICDH) gene on the function of histone demethylases in Arabidopsis thaliana. Loss of cICDH resulted in increases of overall histone H3 lysine 4 trimethylation (H3K4me3) and enhanced mutation defects of the H3K4me3 demethylase gene JMJ14. Genetic analysis suggested that the cICDH mutation may affect the activity of other demethylases, including JMJ15 and JMJ18 that function redundantly with JMJ14 in the plant thermosensory response. Furthermore, we show that mutation of JMJ14 affected both the gene activation and repression programs of the plant thermosensory response and that JMJ14 and JMJ15 repressed a set of genes that are likely to play negative roles in the process. The results provide evidence that histone H3K4 demethylases are involved in the plant response to elevated ambient temperature.
The use of dried blood spots for the serological evaluation of SARS-CoV-2 antibodies
Authors: Toh Zheng Quan , Higgins Rachel A , Anderson Jeremy , Mazarakis Nadia , Do Lien Anh Ha , Rautenbacher Karin , Ramos Pedro , Dohle Kate , Tosif Shidan , Crawford Nigel , Mulholland Kim , Licciardi Paul V 
Published: January 2021

Abstract

Background
To determine if dried blood spot specimens (DBS) can reliably detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies, we compared the SARS-CoV-2 IgG antibody response in paired serum and eluates from DBS specimens.

Methods
A total of 95 paired DBS and serum samples were collected from 74 participants (aged 1–63 years) as part of a household cohort study in Melbourne, Australia. SARS-CoV-2 IgG antibodies specific for the receptor-binding domain (RBD) and S1 proteins between serum and eluates from DBS specimens were compared using an FDA-approved ELISA method.

Results
Among the 74 participants, 42% (31/74) were children and the rest were adults. A total of 16 children and 13 adults were SARS-CoV-2 positive by polymerase chain reaction. The IgG seropositivity rate was similar between serum and DBS specimens (18.9% (18/95) versus 16.8% (16/95)), respectively. Similar RBD and S1-specific IgG levels were detected between serum and DBS specimens. Serum IgG levels strongly correlated with DBS IgG levels (r = 0.99, P &lt; 0.0001) for both SARS-CoV-2 proteins. Furthermore, antibodies remained stable in DBS specimens for &gt;3 months.

Conclusions
DBS specimens can be reliably used as an alternative to serum samples for SARS-CoV-2 antibody measurement. The use of DBS specimens would facilitate serosurveillance efforts particularly in hard-to-reach populations and inform public health responses including COVID-19 vaccination strategies.
Construction of logic gates exploiting resonance phenomena in nonlinear systems
Authors: Murali K. , Rajasekar S. , Aravind Manaoj V. , Kohar Vivek , Ditto W. L. , Sinha Sudeshna 
Published: January 2021

A two-state system driven by two inputs has been found to consistently produce a response mirroring a logic function of the two inputs, in an optimal window of moderate noise. This phenomenon is called logical stochastic resonance (LSR). We extend the conventional LSR paradigm to implement higher-level logic architecture or typical digital electronic structures via carefully crafted coupling schemes. Further, we examine the intriguing possibility of obtaining reliable logic outputs from a noise-free bistable system, subject only to periodic forcing, and show that this system also yields a phenomenon analogous to LSR, termed Logical Vibrational Resonance (LVR), in an appropriate window of frequency and amplitude of the periodic forcing. Lastly, this approach is extended to realize morphable logic gates through the Logical Coherence Resonance (LCR) in excitable systems under the influence of noise. The results are verified with suitable circuit experiments, demonstrating the robustness of the LSR, LVR and LCR phenomena.
This article is part of the theme issue ‘Vibrational and stochastic resonance in driven nonlinear systems (part 1)’.
The effect of high-frequency stochastic actions on the low-frequency behaviour of dynamic systems
Authors: Kremer Eugen 
Published: January 2021

The dynamic system described by a finite number of first-order differential equations is considered. The right side of each equation is a sum of a slow, deterministic and, in the general case, nonlinear function of dynamic variables and a stochastic excitation. The stochastic action is a superposition of a finite number of independent random processes with coefficients depending on dynamic variables and slow time. The problem statement is oriented to applications in the field of driven systems. The analysis is based on the concept of vibration mechanics proposed by I. I. Blekhman. The modified method of direct separation of slow and fast motions uses the explicit introduction of a small parameter and some ideas of the two-scale technique. The general formulas for vibrational forces (or fluxes) are obtained. These additional terms appear in the resulting system for averaged motion instead of the stochastic terms to make the averaged system equivalent to the initial stochastic system with respect to slow motions and, in particular, to low-frequency resonances. As an example, the model of a vibration machine for bulk material processing is considered. The stochastic effect is caused by random oscillations of the bulk material mass. It is transformed into a modification of the machine's frequency characteristics leading to a specific stochastic resonance.
This article is part of the theme issue ‘Vibrational and stochastic resonance in driven nonlinear systems (part 1)’.