bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the impacts of feline epilepsy on cats and their owners
Authors: Henning Julia , Nielson Torben , Nettifee Julie , Muñana Karen , Hazel Susan 
Published: August 2021

AbstractBackgroundEpilepsy is the most common neurological condition reported in cats. Characterised by recurrent seizures, treatment involves the administration of anti‐epileptic drugs up to multiple times a day. Epilepsy and its associated treatments may impact both cats and their owners. The present study aimed to assess factors associated with quality of life (QOL) in cats with epilepsy and the burden of care in their owners.MethodsAn online survey was developed using demographic information and the following validated measures: cat QOL, Zarit burden interview (ZBI) and the cat owner relationship scale (CORS). Regression analysis was conducted using SPSS 26.ResultsResponses were completed by 141 owners from 22 countries. QOL was significantly higher in cats with controlled seizures, no adverse effects from medication and epilepsy onset before 5 years of age. ZBI was significantly lower in owners who felt supported by their veterinarian, who were over 55 and had cats with controlled seizures. Higher CORS was significantly correlated with both higher cat QOL and lower owner ZBI.ConclusionsAdequate seizure control and close cat‐owner relationships may play an important role in mitigating the impact of epilepsy on cats and their owners. Further research into understanding cat‐owner relationships and successfully controlling epilepsy in cats is needed.
Gluon fragmentation into 3$$ {P}_J^{\left[1,8\right]} $$ quark pair and test of NRQCD factorization at two-loop level
Authors: Zhang Peng , Meng Ce , Ma Yan-Qing , Chao Kuang-Ta 
Published: August 2021

AbstractThe next-to-leading order (NLO) ($$ \mathcal{O} $$O($$ {\alpha}_s^3 $$αs3)) corrections for gluon fragmentation functions to a heavy quark-antiquark pair in3$$ {P}_J^{\left[1,8\right]} $$PJ18states are calculated within the NRQCD factorization. We use the integration-by-parts reduction and differential equations to semi-analytically calculate the fragmentation functions in full-QCD, and find that infrared divergences can be absorbed by the NRQCD long distance matrix elements. Thus, the NRQCD factorization conjecture is verified at two-loop level via a physical process, which is free of artificial ultraviolet divergences. Through the matching procedure, infrared-safe short distance coefficients and$$ \mathcal{O} $$O($$ {\alpha}_s^2 $$αs2) perturbative NRQCD matrix elements ⟨$$ {\mathcal{O}}^3{P}_J^{\left[1,8\right]} $$O3PJ18(3$$ {S}_1^{\left[8\right]} $$S18)⟩ are obtained simultaneously. The NLO short distance coefficients are found to have significant corrections comparing with the LO ones.
Understanding the excess psychosis risk in ethnic minorities: the impact of structure and identity
Authors: Jongsma Hannah E. , Karlsen Saffron , Kirkbride James B. , Jones Peter B. 
Published: August 2021

AbstractPurposePsychotic disorders, which are associated with substantially increased morbidity and mortality, are up to five times more common in some ethnic minority groups compared with the white majority in Western countries. This long-standing and well-replicated public mental health disparity has hitherto largely eluded adequate explanation. We argue that this might have arisen in part due to the lack of attention given to theoretical work characterising the complex and multidimensional social nature of ethnicity by those epidemiological investigations that have dominated the literature.MethodsTo bridge this gap, we draw on theoretical and empirical literature from across the social sciences considering the ontological significance of ethnicity (as biology, migration, racialised structures and identity) and its relationships with psychotic disorders to illuminate probable drivers of excess psychosis risk.ResultsThe largest gains in our theoretical understanding of excess psychosis risk among ethnic minority groups are to be made by considering ethnicity in relation to disempowerment resulting from structural and identity-based exclusion. The former is readily studied through the social gradient in health: socioeconomic disadvantage clusters in some ethnic minorities and increases the risk of poor health outcomes, including psychosis. Furthermore, limitations on identity acquisition and expression imposed by the ethnic majority can further contribute to alienate ethnic minorities and increase psychosocial disempowerment (a lack of control over one’s life).ConclusionWe theorise that structural and identity-based exclusion act as the primary drivers shaping variation in rates of psychotic disorder by ethnic minority status.
Relationship Between Changes in Serum Levels of Intact Parathyroid Hormone and Sclerostin After a Single Dose of Zoledronic Acid: Results of a Phase 1 Pharmacokinetic Study
Authors: Kuroda Tatsuhiko , Shiraki Masataka , Nakamura Toshitaka , Suzuki Hiroaki , Hiraishi Kazuki , Sugimoto Toshitsugu , Tanaka Satoshi 
Published: August 2021

AbstractAlthough changes in serum sclerostin levels at 12 months after infusion of zoledronic acid have been reported, the changes in sclerostin levels at earlier time points are poorly understood. We reanalyzed the study data of a previous phase 1 pharmacokinetic study and investigated the correlation between changes in sclerostin levels and relevant factors in calcium metabolism. A total of 24 Japanese female subjects with primary postmenopausal osteoporosis were administered a single 4- or 5-mg dose of zoledronic acid. Serum and urine samples were collected on days 15, 29, 90, 180, and 365 after administration. Serum levels of calcium, phosphate, intact parathyroid hormone (iPTH), and sclerostin were measured. Levels of serum sclerostin were unchanged from baseline on days 15 and 29, but increased significantly on day 90, subsequently decreased significantly on day 180, and returned to baseline levels on day 365. A significant negative correlation was observed between changes in iPTH levels at early time points and sclerostin levels at later time points. This suggests that sclerostin was negatively regulated by iPTH, and the decrease in sclerostin may indicate the start of bone formation during later time points after zoledronic acid injection.
Dural venous sinus anatomy in children with external hydrocephalus: analysis of a series of 97 patients
Authors: Cinalli Giuseppe , di Martino Giuliana , Russo Carmela , Mazio Federica , Nastro Anna , Mirone Giuseppe , Ruggiero Claudio , Aliberti Ferdinando , Cascone Daniele , Covelli Eugenio , Spennato Pietro 
Published: August 2021

AbstractPurposeTo evaluate the anatomical variations of dural venous sinuses in children with external hydrocephalus, proposing a radiological grading of progressive anatomic restriction to venous outflow based on brain phase-contrast magnetic resonance venography (PC-MRV); to evaluate the correlation between positional plagiocephaly and dural sinuses patency; and to compare these findings with a control group to ascertain the role of anatomical restriction to venous outflow in the pathophysiology of external hydrocephalus.MethodsBrain MRI and PC MRV were performed in 97 children (76 males, 21 females) diagnosed with external hydrocephalus at an average age of 8.22 months. Reduction of patency of the dural sinuses was graded as 1 (stenosis), 2 (complete stop) and 3 (complete agenesis) for each transverse/sigmoid sinus and sagittal sinus. Anatomical restriction was graded for each patient from 0 (symmetric anatomy of patent dural sinuses) through 6 (bilateral agenesis of both transverse sinuses). Ventricular and subarachnoid spaces were measured above the intercommissural plane using segmentation software. Positional plagiocephaly (PP) and/or asymmetric tentorial insertion (ATI) was correlated with the presence and grading of venous sinus obstruction. These results were compared with a retrospective control group of 75 patients (35 males, 40 females).ResultsBoth the rate (84.53% vs 25.33%) and the grading (mean 2.59 vs mean 0.45) of anomalies of dural sinuses were significantly higher in case group than in control group. In the case group, sinus anomalies were asymmetric in 59 cases (right-left ratio 1/1) and symmetric in 22. A significant association was detected between the grading of venous drainage alterations and diagnosis of disease and between the severity of vascular anomalies and the widening of subarachnoid space (SAS). Postural plagiocephaly (39.1% vs 21.3%) and asymmetric tentorial insertion (35.4% vs 17.3%) were significantly more frequent in the case group than in the control group. When sinus anomalies occurred in plagiocephalic children, the obstruction grading was significantly higher on the flattened side (p ≤ 0.001).ConclusionDecreased patency of the dural sinuses and consequent increased venous outflow resistance may play a role in the pathophysiology of external hydrocephalus in the first 3 years of life. In plagiocephalic children, calvarial flattening may impact on the homolateral dural sinus patency, with a possible effect on the anatomy of dural sinuses and venous drainage in the first months of life.
Science-based policy: targeted nutrition for all ages and the role of bioactives
Authors: Kalache Alexandre , Bazinet Richard P. , Carlson Susan , Evans William J. , Kim Chi Hee , Lanham-New Susan , Visioli Francesco , Griffiths James C. 
Published: August 2021

AbstractGlobally, there has been a marked increase in longevity, but it is also apparent that significant inequalities remain, especially the inequality related to insufficient ‘health’ to enjoy or at least survive those later years. The major causes include lack of access to proper nutrition and healthcare services, and often the basic information to make the personal decisions related to diet and healthcare options and opportunities. Proper nutrition can be the best predictor of a long healthy life expectancy and, conversely, when inadequate and/or improper a prognosticator of a sharply curtailed expectancy. There is a dichotomy in both developed and developing countries as their populations are experiencing the phenomenon of being ‘over fed and under nourished’, i.e., caloric/energy excess and lack of essential nutrients, leading to health deficiencies, skyrocketing global obesity rates, excess chronic diseases, and premature mortality. There is need for new and/or innovative approaches to promoting health as individuals’ age, and for public health programs to be a proactive blessing and not an archaic status quo ‘eat your vegetables’ mandate. A framework for progress has been proposed and published by the World Health Organization in their Global Strategy and Action Plan on Ageing and Health (WHO (2017) Advancing the right to health: the vital role of law. https://apps.who.int/iris/bitstream/handle/10665/252815/9789241511384-eng.pdf?sequence=1&isAllowed=y. Accessed 07 Jun 2021; WHO (2020a) What is Health Promotion. www.who.int/healthpromotion/fact-sheet/en/. Accessed 07 Jun 2021; WHO (2020b) NCD mortality and morbidity. www.who.int/gho/ncd/mortality_morbidity/en/. Accessed 07 Jun 2021). Couple this WHO mandate with current academic research into the processes of ageing, and the ingredients or regimens that have shown benefit and/or promise of such benefits. Now is the time for public health policy to ‘not let the perfect be the enemy of the good,’ but to progressively make health-promoting nutrition recommendations.
PERMIT study: a global pooled analysis study of the effectiveness and tolerability of perampanel in routine clinical practice
Authors: Villanueva Vicente , D’Souza Wendyl , Goji Hiroko , Kim Dong Wook , Liguori Claudio , McMurray Rob , Najm Imad , Santamarina Estevo , Steinhoff Bernhard J. , Vlasov Pavel , Wu Tony , Trinka Eugen ,   the PERMIT pooled analysis participants
Published: August 2021

AbstractThe PERaMpanel pooled analysIs of effecTiveness and tolerability (PERMIT) study was a pooled analysis of data from 44 real-world studies from 17 countries, in which people with epilepsy (PWE; focal and generalized) were treated with perampanel (PER). Retention and effectiveness were assessed after 3, 6, and 12 months, and at the last visit (last observation carried forward). Effectiveness assessments included 50% responder rate (≥ 50% reduction in seizure frequency from baseline) and seizure freedom rate (no seizures since at least the prior visit); in PWE with status epilepticus, response was defined as seizures under control. Safety and tolerability were assessed by evaluating adverse events (AEs) and discontinuation due to AEs. The Full Analysis Set included 5193 PWE. Retention, effectiveness and safety/tolerability were assessed in 4721, 4392 and 4617, respectively. Retention on PER treatment at 3, 6, and 12 months was 90.5%, 79.8%, and 64.2%, respectively. Mean retention time on PER treatment was 10.8 months. The 50% responder rate was 58.3% at 12 months and 50.0% at the last visit, and the corresponding seizure freedom rates were 23.2% and 20.5%, respectively; 52.7% of PWE with status epilepticus responded to PER treatment. Overall, 49.9% of PWE reported AEs and the most frequently reported AEs (≥ 5% of PWE) were dizziness/vertigo (15.2%), somnolence (10.6%), irritability (8.4%), and behavioral disorders (5.4%). At 12 months, 17.6% of PWEs had discontinued due to AEs. PERMIT demonstrated that PER is effective and generally well tolerated when used to treat people with focal and/or generalized epilepsy in everyday clinical practice.
Amyotrophic lateral sclerosis (ALS) among immigrant groups and Swedish-born individuals: a cohort study of all adults 18 years of age and older in Sweden
Authors: Wändell Per , Fredrikson Sten , Carlsson Axel C. , Li Xinjun , Sundquist Jan , Sundquist Kristina 
Published: August 2021

Abstract
Background
There is a lack of studies of amyotrophic lateral sclerosis (ALS) in immigrants.

Objective
The objective is to study the association between country of birth and incident ALS in first-generation immigrants versus Swedish-born individuals, and in second-generation immigrants versus native Swedes.

Methods
Study populations included all adults aged 18 years and older in Sweden, in the first-generation study 6,128,698 individuals (2,975,141 men, 3,153,557 women) with 5,344 ALS cases (3017 men, 2327 women), and in the second-generation study 4,588,845 individuals (2,346,855 men and 2,241,990 women) with 3,420 cases (2027 men and 1393 women). ALS was defined as having at least one registered diagnosis of ALS in the National Patient Register 1998–2017. The incidence of ALS in different first-generation immigrant groups versus Swedish-born individuals was assessed by Cox regression, expressed as hazard ratios (HRs) with 95% confidence intervals (CI). The models were stratified by sex and adjusted for age, geographical residence in Sweden, educational level, marital status, and neighbourhood socioeconomic status.

Results
After adjusting for potential confounders, the HRs were lower in foreign-born men, 0.71 (95% CI 0.63–0.81), and women, 0.80 (95% CI 0.70–0.92). The ALS risk was lower among men and women from most Western countries (Europe outside Nordic countries, and North America), and from other regions of the world (Africa, Asia, and Latin America). Among men and women with foreign-born parents, the risk of ALS did not differ significantly from native Swedes.

Significance
In general, the risk of ALS was lower in first-generation men and women but did not differ in second-generation individuals.
Bactericidal activity of three different antiseptic ophthalmic preparations as surgical prophylaxis
Authors: Tognetto Daniele , Pastore Marco R. , Guerin Gian Marco , Decorti Giuliana , Franzin Martina , Lagatolla Cristina , Cirigliano Gabriella 
Published: August 2021

Abstract
Purpose
In the era of antibiotic resistance, there is an increased interest in antiseptic solutions that might represent a reliable option for ocular surface disinfection. The objective of this study is to compare for the first time three different antiseptic ophthalmic preparations to assess their in vitro antimicrobial activity.

Methods
The antiseptic activity of three commercial ophthalmic solutions, IODIM (povidone-iodine 0.6% in hyaluronic acid vehicle—Medivis, Catania, Italy), OZODROP (nanoemulsion with ozonated oil—concentration not specified—FBVision, Ophthalmic Pharmaceuticals, Rome, Italy), and DROPSEPT (chlorhexidine 0.02% and vitamin E 0.5% Tocopherol Polyethylene Glycol 1000 Succinate—TPGS, Sooft Italia, Montegiorgio, Italy), was tested in vitro on six reference strains by time-killing assays. Viable cells were evaluated after 1, 15, 30 min; 2, 6, and 24 h exposure by seeding 100 µl of the suspension (or appropriate dilutions) on LB agar or Sabouraud-dextrose agar. All plates were incubated at 37 °C for 24 h and evaluated by manually counting the colonies.

Results
IODIM solution showed a very rapid microbicidal activity: the number of viable cells for all the tested strains was under the detection limit (less than 10 CFU/ml) already after 1 min exposure, and this result was maintained at every incubation time. The rapid antimicrobial activity of povidone-iodine was not replicated when testing the other two antiseptics.

Conclusions
The study reports the great efficacy in reducing bacterial load in a very short time of povidone-iodine 0.6% compared with other antiseptic preparations.
Estimating surface runoff and groundwater recharge in an urban catchment using a water balance approach
Authors: Weatherl Robin K. , Henao Salgado Maria J. , Ramgraber Maximilian , Moeck Christian , Schirmer Mario 
Published: August 2021

AbstractLand-use changes often have significant impact on the water cycle, including changing groundwater/surface-water interactions, modifying groundwater recharge zones, and increasing risk of contamination. Surface runoff in particular is significantly impacted by land cover. As surface runoff can act as a carrier for contaminants found at the surface, it is important to characterize runoff dynamics in anthropogenic environments. In this study, the relationship between surface runoff and groundwater recharge in urban areas is explored using a top-down water balance approach. Two empirical models were used to estimate runoff: (1) an updated, advanced method based on curve number, followed by (2) bivariate hydrograph separation. Modifications were added to each method in an attempt to better capture continuous soil-moisture processes and explicitly account for runoff from impervious surfaces. Differences between the resulting runoff estimates shed light on the complexity of the rainfall–runoff relationship, and highlight the importance of understanding soil-moisture dynamics and their control on hydro(geo)logical responses. These results were then used as input in a water balance to calculate groundwater recharge. Two approaches were used to assess the accuracy of these groundwater balance estimates: (1) comparison to calculations of groundwater recharge using the calibrated conceptual HBV Light model, and (2) comparison to groundwater recharge estimates from physically similar catchments in Switzerland that are found in the literature. In all cases, recharge is estimated at approximately 40–45% of annual precipitation. These conditions were found to closely echo those results from Swiss catchments of similar characteristics.
Patient-specific simulation of stent-graft deployment in type B aortic dissection: model development and validation
Authors: Kan Xiaoxin , Ma Tao , Lin Jing , Wang Lu , Dong Zhihui , Xu Xiao Yun 
Published: August 2021

AbstractThoracic endovascular aortic repair (TEVAR) has been accepted as the mainstream treatment for type B aortic dissection, but post-TEVAR biomechanical-related complications are still a major drawback. Unfortunately, the stent-graft (SG) configuration after implantation and biomechanical interactions between the SG and local aorta are usually unknown prior to a TEVAR procedure. The ability to obtain such information via personalised computational simulation would greatly assist clinicians in pre-surgical planning. In this study, a virtual SG deployment simulation framework was developed for the treatment for a complicated aortic dissection case. It incorporates patient-specific anatomical information based on pre-TEVAR CT angiographic images, details of the SG design and the mechanical properties of the stent wire, graft and dissected aorta. Hyperelastic material parameters for the aortic wall were determined based on uniaxial tensile testing performed on aortic tissue samples taken from type B aortic dissection patients. Pre-stress conditions of the aortic wall and the action of blood pressure were also accounted for. The simulated post-TEVAR configuration was compared with follow-up CT scans, demonstrating good agreement with mean deviations of 5.8% in local open area and 4.6 mm in stent strut position. Deployment of the SG increased the maximum principal stress by 24.30 kPa in the narrowed true lumen but reduced the stress by 31.38 kPa in the entry tear region where there was an aneurysmal expansion. Comparisons of simulation results with different levels of model complexity suggested that pre-stress of the aortic wall and blood pressure inside the SG should be included in order to accurately predict the deformation of the deployed SG.
Effect of overload on changes in mechanical and structural properties of the annulus fibrosus of the intervertebral disc
Authors: Żak Małgorzata , Pezowicz Celina 
Published: August 2021

AbstractThe research focussed on analysing structural and mechanical properties in the intervertebral disc (IVD), caused by long-term cyclic loading. Spinal motion segments were divided into two groups: the control (C), and the group in which it was analysed the impact of posterior column in the load-bearing system of the spine—specimens with intact posterior column (IPC) and without posterior column (WPC). To evaluate the structural and mechanical changes, the specimens were tested with simulation of 100,000 compression-flexion load cycles after which it was performed macroscopic analysis. Mechanical properties of the annulus fibrosis (AF) from the anterior and posterior regions of the IVD were tested at the uniaxial tension test. The stiffness coefficient values were statistically 32% higher in the WPC group (110 N/mm) than in the IPC (79 N/mm). The dynamics of increase in this parameter does not correspond with the course of decrease in height loss. WPC segments revealed clear structural changes that mainly involve the posterior regions of the IVD (bulging and delamination with the effect of separation of collagen fibre bundles). Pathological changes also caused decreases in the value of stress in the AF. The greatest changes in the stress value about group C (7.43 ± 4.49 MPa) were observed in the front part of the fibrous ring, where this value was for IPC 4.49 ± 4.78 MPa and WPC 2.56 ± 1.01 MPa. The research indicates that the applied load model allows simulating damage that occurs in pathological IVD. And the posterior column’s presence affects this change’s dynamics, structural and mechanical properties of AF.