bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERJUANGAN SYEKH SULAIMAN AR-RASULI DALAM MEMAJUKAN AGAMA ISLAM DI RANAH MINANG
Authors: Nisa Elvira , Wahyuni Anny , Purnomo Budi 
Published: July 2021

Canduang merupakan salah satu kota penting di daerah Sumatera Barat. Di daerah Canduang inilah hidup seorang Syekh besar bernama Syekh Sulaiman Ar-Rasuli. Penelitian ini bertujuan untuk menguraikan tentang bagaimana perjuangan Syekh Sulaiman ar-rasuli dalam menyebarkan pengaruh agama Islam di daerah Minangkabau. Metode yang digunakan dalam penelitian ini adalah metode penelitian sejarah. Data dikumpulkan melalui tinjauan pustaka dari buku novel historiografi Syekh Sulaiman Ar-Rasuli yang berjudul Inyiak Sang Pejuang. Antara banyaknya informasi yang terdapat pada buku Inyiak Sang Pejuang ini, Artikel kali ini terfokus pada perjuangan Syekh Sulaiman Ar-Rasuli dalam menyebarkan agama Islam di daerah Minangkabau yang pada saat itu menghadapi pengaruh dari penjajahan Belanda dan Jepang yang pada masa itu sedang menjajah tanah Minang. Dimulai dari perjalanan Syekh Sulaiman Ar-Rasuli mendapatkan pengetahuan agama dan hambatan yang dialami beliau, usaha Syekh Sulaiman Ar-Rasuli dalam menyebarluaskan kan agama Islam di tengah-tengah masalah yang dihadapi tanah Minang dengan para penjajah juga dengan penyelewengan aqidah Islam oleh pribumi daerah Padang itu sendiri. Hasil penelitian menunjukkan bahwa Syekh Sulaiman Ar-Rasuli memiliki sikap seperti berikut yang membuktikan bahwa Syekh Sulaiman Ar-Rasuli melakukan perjuangan dalam menyebar luaskan ajaran Islam di daerah Minang yaitu: 1) bersungguh-sungguh dalam menuntut ilmu 2) pekerja keras 3) nasionalisme.
Describing Ship-Design
Authors: van Bruinessen Ties , Hopman Hans , Smulders Frido 
Published: July 2021

The majority of European ship-design industry concentrates on the development of complex, one-off ‘specials’ for the offshore industry, like dredgers, drill ships, pipe-laying ships, et cetera. This industry is complex, not just in terms of the industrial structure but also in the terms of the object. To control the complexity the industry uses large and expansive knowledge basis that support the design, engineering and manufacturing activities. Within academic research the focus is close to practice and dominantly aims at developing knowledge and tools that supports engineering practices. As these strategies are aimed at controlling the complexity, they leave very little room for more innovative developments. On the other side of the spectrum there is a ship-design practice that does allow radical ship design: design and engineering from a blank sheet of paper. Not surprising that these projects are laborious and expensive. The space in between these two design strategies seems unaddressed in literature. The literature on the design of complex structures appears to be scarce, even though this is an area where European ship-design industry is heavily involved. The research this paper reports on aims to develop a design strategy for complex ships in between incremental and radical innovation.
We interviewed stakeholders from ship industry, looked into the design literature to describe the present situation and finally performed case-studies in other fields of application for inspiration. Based on these studies we illustrate an alternative design strategy that leaves more space for innovation without the requirement to start from scratch. The approach focuses on the complex interactions between the different levels of decomposition in a complex structure such as a ship.
Improved Estimation of Ship Construction Completion by RFID Tags
Authors: Latorre Robert , Comer Joe , Basaran Altug , Trippi Josh 
Published: July 2021

This paper presents the extension of the 3-D model to the production problem of estimating construction completion. This has several benefits:
1 Timely billing for work completed.
2 Daily updates on construction completion/progress.
3 Improved material and manpower utilization from an accurate tracking of production schedule.
Connecting the digital 3-D model to the as build structure requires introducing bar code labels and Radio Frequency Identification Device (RFID) tags and readers. The paper discusses many aspects of RFID tag selection and applications. The paper closes with a discussion of how the bar codes and RFID tags can be used to improve the shipbuilding progress payment. By this improvement, the modest cost of the tags and readers can be easily recovered.
La Valoración de las ideas creativas por parte del anunciante
Authors: Fajula Payet Anna 
Published: July 2021

La creatividad ocupa un rol nuclear dentro de la comunicación publicitaria, pero ¿el anunciante lo tiene en cuenta como un factor esencial a la hora de juzgar y dar el visto bueno a las ideas comunicativas que una agencia le presenta? El objetivo principal de este artículo es el de identificar los elementos que, desde el punto de vista de los anunciantes, son claves en su proceso de valoración y aprobación de las ideas comunicativas; detectar los elementos que pueden facilitar o dificultar que un anunciante valore favorablemente una propuesta y comprobar si la creatividad es uno de ellos. Para ello, se planteó una investigación con un enfoque cualitativo y carácter exploratorio en la que se llevaron a cabo entrevistas en profundidad a seis anunciantes que operan en el mercado español. Los resultados obtenidos, utilizando el análisis de contenido y la Teoría Fundamentada, ponen de manifiesto que la propuesta de la agencia no se valora de manera aislada sino que, más allá de la idea, hay un abanico de elementos intangibles que ejercen una enorme influencia sobre la decisión final del anunciante. La creatividad es una característica que se da por supuesta, se asimila a originalidad y se equipara a un medio para conseguir unos determinados objetivos empresariales. A su vez, el enfoque del artículo proporciona una visión del anunciante tradicionalmente ignorada en la literatura publicitaria: su condición no solo como emisor, sino también como público objetivo de la comunicación comercial.
‘Virtually’ the same learning outcomes. A case study of a virtual client briefed communication project across borders
Authors: Duarte Alexandre , Riedl Kirstie 
Published: July 2021

As the world becomes increasingly more turbulent, complex and competitive, there has been an increased interest in creativity as the major force to prepare students for these demands. At the same time, digital native students today are used to working in an environment rich with instantly accessible information and knowledge, yet paradoxically students are less satisfied with their courses in the online environment. Educators are thus challenged to use innovative methods to nurture creativity online as they would do in the face-to-face classroom.
In 2010, six European universities created an international project, named Cross Border Brand Communication (CBBC) that has taken place every year since but in 2020 took place online due to the Covid-19 pandemic. This article describes and analyzes the best practices resulting from this case and addresses the research questions as to whether the creative learning outcomes and teaching practices online are the same as face-to-face and to what extent are students satisfied with this learning environment. Reflection on the project and case indicates that although learning outcomes online are “virtually” the same, the student experience is inferior to such face-to-face projects.
Analysis of ceRNA network of differentially expressed genes in FaDu cell line and a cisplatin-resistant line derived from it
Authors: Zhang Gehou , Tan Guolin , Li Tieqi , Ai Jingang , Song Yexun , Zhou Zheng , Xiao Jian , Li Wei 
Published: July 2021

Background
Hypopharyngeal cancer accounts for 2% in head and neck cancers and has a poor prognosis. Cisplatin is a widely used chemotherapeutic drug in kinds of carcinomas, concluding hypopharyngeal cancer. However, the resistance of cisplatin appeared in recent years. Cisplatin-resistance has been partly explored before, but rarely in hypopharyngeal cancer.

Methods
We cultured the hypopharyngeal cancer cell (FaDu) and induced its cisplatin-resistant cell (FaDu/DDP4). Then we tested the differentially expressed genes (DEGs) between FaDu and FaDu/DDP4. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were conducted on the DEGs, and we drew the ceRNA networks of DEGs. Finally, we chose eight miRNAs and six mRNAs for qRT-PCR to verify our microarray.

Results
We induced cisplatin-resistant FaDu/DDP4 and proved its chemoresistance. The resistance index (RI) of FaDu/DDP4 was 2.828. DEGs contain 2,388 lncRNAs, 1,932 circRNAs, 745 mRNAs and 202 miRNAs. These 745 mRNAs were classified into three domains and 47 secondary GO terms. In KEGG pathway enrichment, the “TNF signaling pathway”, “IL-17 signaling pathway” and “JAK-STAT signaling pathway” were potentially significant signaling pathways. Then, 52 lncRNAs, 148 circRNAs, 155 mRNAs and 18 miRNAs were selected to draw the network. We noticed several potential targets (as miR-197-5p, miR-6808-5p, APOE, MMP1, S100A9 and CYP24A1). At last, the eight miRNAs and six mRNAs that are critical RNAs in ceRNA network were verified by qRT-PCR.

Conclusion
The microarray helped to find DEGs in cisplatin-resistant hypopharyngeal cancer. TNF, IL-17 and JAK-STAT signaling pathways might be more significant for cisplatin-resistance. MiR-197-5p, miR-6808-5p, APOE, MMP1, S100A9 and CYP24A1 might be potential genes inducing resistance.
Soil-Transmitted Helminths Infection and Associated Risk Factors among Primary School Pupils in Omogho and Awa Communities, Anambra State, Nigeria
Authors: Nwankwo Amarachukwu , Onyebueke Anthony Chibuike , Irikannu Kindness Chidi , Nzeukwu Chibumma Immaculata , Onwuzulike Ifediba Vivian , Okafor Nnazimuzo Maria 
Published: July 2021

Background: Soil-Transmitted Helminths (STHs) remain a public health problem. Infections are widely distributed in tropical and subtropical areas of the world.
Aim: This study was to investigate the prevalence and intensity of STH infections, the prevalence of STH mixed infections in relation to age and sex, and to identify the risk factors associated with STH infections among pupils in Omogho and Awa rural communities in Orumba North Local Government Area, Anambra State, Nigeria.
Study design: The study was a cross-sectional survey of faecal samples collected from 453 randomly selected pupils from four primary schools.
Duration of study: The study was conducted between June and September 2017.
Materials and methods: The faecal samples were examined by direct smear and formol ether concentration techniques. Questionnaires based survey was done to determine the risk factors of STH among the pupils.
Results: The overall prevalence of STH infections was 44.2%. Among the schools, Primary School, Awa had the highest prevalence (17.0%) while Daughters of Mary Mother of Mercy Primary School, Omogho, had the least prevalence (5.3%). Others were Community Primary School, Omogho (12.8%) and Community Primary School, Awa (9.1%). There was no significant difference in the prevalence of STH infections among the primary school pupils (p = 0.36, p > .05). Ascaris lumbricoides (17.2%) was highest while Strongyloides stercoralis (2.0%) was the least prevalent. Other STHs observed were hookworms (15.9%) and Trichuris trichiura (9.1%). Pupils who do not practice proper hygiene had highest infections. A total of 149(32.9%) who do not wash hands after the use of toilet had more infections than 51(11.3%) who wash their hands. There was significant difference on prevalence of STH with responses on hygiene practices (p = 0.00, p < .05).
Conclusion: Absence of good toilet facility and adequate water supply in the schools made it difficult for the pupils to practice good hygiene. An integrated control of STH which should include provision of adequate toilet facilities for pupils, piped drinking water, chemotherapy and health education is recommended.
Mesotoga
Authors: Nesbø Camilla , L'Haridon Stéphane , Farrell Anne , Zhaxybayeva Olga 
Published: July 2021

Abstract

Me.so.to'ga. Gr. masc. adj.
mesos
middle; L. fem. n.
toga
Roman outer garment; N.L. fem. n.
Mesotoga
, a “garment in the middle,” referring to its moderate optimal growth temperature and the presence of a toga‐like outer sheath.

Thermotogota / Thermotogae / Kosmotogales / Kosmotogaceae / Mesotoga

Mesotoga
spp. are
mesophilic obligate heterotrophs
, with optimum growth temperature between 37 and 45°C, optimal pH of 6.9–7.5, and optimal salinity of 0.2–4.0 (NaCl w/v%). These bacteria utilize
sugar in the presence of sulfur
,
thiosulfate
, or in association with a
syntrophic hydrogenotrophic partner
. The cells are Gram‐stain negative short rods to ovoid cocci with a sheath‐like structure.
Mesotoga
spp. are members of the phylum
Thermotogota
, class
Thermotogae
, order
Kosmotogales
, and family
Kosmotogaceae
. The genus is currently composed of two described species,
M. prima
and
M. infera
. The known habitats are deep aquifers, marine anoxic sediments, hydrocarbon‐impacted environments, and anaerobic man‐made environments.

DNA G + C content (mol%)
: 45.2–48.3 (genome analysis).

Type species
:
Mesotoga prima
Nesbø et al. 2012, VL149.
Nanoparticle and Biomolecule Surface Modification Synergistically Increases Neural Electrode Recording Yield and Minimizes Inflammatory Host Response
Authors: Woeppel Kevin M. , Cui Xinyan Tracy 
Published: July 2021

AbstractDue to their ability to interface with neural tissues, neural electrodes are the key tool used for neurophysiological studies, electrochemical detection, brain computer interfacing, and countless neuromodulation therapies and diagnostic procedures. However, the long‐term applications of neural electrodes are limited by the inflammatory host tissue response, decreasing detectable electrical signals, and insulating the device from the native environment. Surface modification methods are proposed to limit these detrimental responses but each has their own limitations. Here, a combinatorial approach is presented toward creating a stable interface between the electrode and host tissues. First, a thiolated nanoparticle (TNP) coating is utilized to increase the surface area and roughness. Next, the neural adhesion molecule L1 is immobilized to the nanoparticle modified substrate. In vitro, the combined nanotopographical and bioactive modifications (TNP+L1) elevate the bioactivity of L1, which is maintained for 28 d. In vivo, TNP+L1 modification improves the recording performance of the neural electrode arrays compared to TNP or L1 modification alone. Postmortem histology reveals greater neural cell density around the TNP+L1 coating while eliminating any inflammatory microglial encapsulation after 4 weeks. These results demonstrate that nanotopographical and bioactive modifications synergistically produce a seamless neural tissue interface for chronic neural implants.
Aggregation‐Induced Emission‐Based Platforms for the Treatment of Bacteria, Fungi, and Viruses
Authors: Chen Xiaohui , Han Haijie , Tang Zhe , Jin Qiao , Ji Jian 
Published: July 2021

AbstractThe prevention and control of pathogenic bacteria, fungi, and viruses is a herculean task for all the countries since they greatly threaten global public health. Rapid detection and effective elimination of these pathogens is crucial for the treatment of related diseases. It is urgently demanded to develop new diagnostic and therapeutic strategies to combat bacteria, fungi, and viruses‐induced infections. The emergence of aggregation‐induced emission (AIE) luminogens (AIEgens) is a revolutionary breakthrough for the treatment of many diseases, including pathogenic infections. In this review, the main focus is on the applications of AIEgens for theranostic treatment of pathogenic bacteria, fungi, and viruses. Due to the AIE characteristic, AIEgens are promising fluorescent probes for the detection of bacteria, fungi, and viruses with excellent sensitivity and photostability. Moreover, AIEgen‐based theranostic platforms can be fabricated by introducing bactericidal moieties or designing AIE photosensitizers and AIE photothermal agents. The current strategies and ongoing developments of AIEgens for the treatment of pathogenic bacteria, fungi, and viruses will be discussed in detail.
Size‐Confined Effects of Nanostructures on Fibronectin‐Induced Macrophage Inflammation on Titanium Implants
Authors: Qi Haoning , Shi Miusi , Ni Yueqi , Mo Wenting , Zhang Peng , Jiang Shuting , Zhang Yufeng , Deng Xuliang 
Published: July 2021

AbstractMacrophage activation determines the fate of biomaterials implantation. Though researches have shown that fibronectin (FN) is highly involved in integrin‐induced macrophage activation on biomaterials, the mechanism of how nanosized structure affects macrophage behavior is still unknown. Here, titanium dioxide nanotube structures with different sizes are fabricated to investigate the effects of nanostructure on macrophage activation. Compared with larger sized nanotubes and smooth surface, 30 nm nanotubes exhibit considerable lesser pro‐inflammatory properties on macrophage differentiation. Confocal protein observation and molecular dynamics simulation show that FN displays conformation changes on different nanotubes in a feature of “size‐confined,” which causes the hiding of Arg‐Gly‐Asp (RGD) domain on other surfaces. The matching size of nanotube with FN allows the maximum exposure of RGD on 30 nm nanotubes, activating integrin‐mediated focal adhesion kinase (FAK)‐phosphatidylinositol‐3 kinase γ (PI3Kγ) pathway to inhibit nuclear factor kappa B (NF‐κB) signaling. In conclusion, this study explains the mechanism of nanostructural‐biological signaling transduction in protein and molecular levels, as well as proposes a promising strategy for surface modification to regulate immune responses on bioimplants.
Controlled Access to C1‐Symmetrical Cyclotriveratrylenes (CTVs) by Using a Sequential Barluenga Boronic Coupling (BBC) Approach
Authors: Vigier Clément , Fossé Pierre , Fabis Frédéric , Cailly Thomas , Dubost Emmanuelle 
Published: July 2021

AbstractWe describe here a controlled approach to C1‐symmetrical cyclotriveratrylenes (CTVs). In this approach dimers are synthesized through Barluenga boronic coupling (BBC) and after borylation, the last aromatic ring is introduced by a second BBC. After functional transformations of the trimers, the CTVs are formed using intramolecular SEAr.magnified image
3D Carbon−Metal Oxide Composite Electrodes on Graphite‐Coated Stainless Steel Substrate as a High‐Performance Anode for Lithium‐Ion Batteries
Authors: Mamidi Suresh , Potphode Darshna , Pathak Anil D. , Sharma Chandra S. 
Published: July 2021

3D microelectrodes are known to offer significant advantages compared with conventional thin‐film electrodes due to their large surface area and shorter diffusion lengths. However, the direct use of 3D microelectrodes on bare stainless steel (SS) causes low rate capabilities, poor cycling performance, and safety concerns. Herein, these issues are addressed by designing 3D microelectrodes on the graphite‐coated substrate with deposition of metal‐organic framework (MOF)‐derived nanostructured cobalt oxide petals at the base of the microelectrodes array. In this electrode configuration, graphite coating serves as an electrical interface between the microelectrodes and substrate, which lowers the resistance by providing efficient electron‐conducting pathways. The cobalt oxide facilitates Li‐ion diffusion and enhances the storage capability by conversion redox reactions. As an anode material, this 3D composite electrode delivers outstanding performance with a discharge capacity of 913 mAh g−1 at 100 mA g−1 current density even after 200 cycles.Furthermore, a diffusion‐limited model using the finite element method is developed to investigate the time‐dependent Li‐ion transport across 3D microelectrodes. The computational study demonstrates the advantages of 3D carbon microelectrode morphology over the conventional planar electrodes. The excellent cyclic stability with outstanding specific capacities confirms the potential applicability of this novel electrode for high‐performance lithium‐ion batteries.
Pharmacological treatment to reduce pulmonary morbidity after esophagectomy
Authors: Shinozaki Hiroharu , Matsuoka Tadashi , Ozawa Soji 
Published: July 2021

AbstractEsophagectomy for esophageal cancer is one of the most invasive procedures in gastrointestinal surgery. An invasive surgical procedure causes postoperative lung injury through the surgical procedure and one‐lung ventilation during anesthesia. Lung injury developed by inflammatory response to surgical insults and oxidative stress is associated with pulmonary morbidity after esophagectomy. Postoperative pulmonary complications negatively affect the long‐term outcomes; therefore, an effort to reduce lung injury improves overall survival after esophagectomy. Although significant evidence has not been established, various pharmacological treatments for reducing lung injury, such as administration of a corticosteroid, neutrophil elastase inhibitor, and vitamins are considered to have efficacy for pulmonary morbidity. In this review we survey the following topics: mediators during the perioperative periods of esophagectomy and the efficacy of pharmacological therapies for patients with esophagectomy on pulmonary complications.
Does obesity mediate the relationship between diabetes and osteoporosis in Chinese elderly population?
Authors: He Pei , Zhong Jiao , Zhu Dong‐Cheng , Ge Bing , Lei Shu‐Feng , Deng Fei‐Yan 
Published: July 2021

AbstractObjectivesDiabetes mellitus (DM), osteoporosis (OP), and obesity (OB) are three complex diseases. OB is associated with both DM and OP, but it is unclear whether OB mediates association between DM and OP. The study aimed to investigate the potential mediation effects of OB on association between DM and bone mineral density (BMD) by the causal inference tests (CIT).MethodsA total of 5682 Chinese aged over 65 years were enrolled in an ongoing cohort: Osteoporosis Preventive Project (OPP). Obesity‐related indexes, including body mass index (BMI), waist circumference, and waist circumference‐hip circumference‐ratio (WHR), and BMD at total hip (TH) and femur neck (FN) were measured.ResultsSubjects with DM had significant greater values of age, weight, BMI, waist circumference, WHR, and BMD than non‐DM subjects. BMD at TH and FN was significantly associated with DM (p < 0.05) with adjustment of age both in males and females. Further CIT showed that OB‐related indexes (BMI, waist circumference, and WHR) are significantly mediators in the associations between DM and BMD in females, but not in males. Furthermore, the mediation effects of waist circumference were detected on DM and TH BMD in the females of normal‐weight group.ConclusionsObesity‐related indexes, especially waist circumference, serve as significant mediator(s) between DM and OP in Chinese female elderly. Diabetes increases BMD by increasing obesity‐related indexes. The findings established the intermediate role of OB underlying the association between DM and OP in human population.