bluuebunny/crossref_metadata_2025_split huggingface dataset:
New positivity bounds from full crossing symmetry
Authors: Tolley Andrew J. , Wang Zi-Yue , Zhou Shuang-Yong 
Published: May 2021

Abstract
Positivity bounds are powerful tools to constrain effective field theories. Utilizing the partial wave expansion in the dispersion relation and the full crossing symmetry of the scattering amplitude, we derive several sets of generically nonlinear positivity bounds for a generic scalar effective field theory: we refer to these as the P Q, Dsu, Dstu and $$ {\overline{D}}^{\mathrm{stu}} $$

D
¯

stu

bounds. While the PQ bounds and Dsu bounds only make use of the s↔u dispersion relation, the Dstu and $$ {\overline{D}}^{\mathrm{stu}} $$

D
¯

stu

bounds are obtained by further imposing the s↔t crossing symmetry. In contradistinction to the linear positivity for scalars, these inequalities can be applied to put upper and lower bounds on Wilson coefficients, and are much more constraining as shown in the lowest orders. In particular we are able to exclude theories with soft amplitude behaviour such as weakly broken Galileon theories from admitting a standard UV completion. We also apply these bounds to chiral perturbation theory and we find these bounds are stronger than the previous bounds in constraining its Wilson coefficients.
A note on generalized invertibility and invariants of infinite matrices
Authors: Seidel Markus 
Published: May 2021

AbstractThe classes of band-dominated operators and the subclass of operators in the Wiener algebra $${\mathcal {W}}$$
W
are known to be inverse closed. This paper studies and extends partially known results of that type for one-sided and generalized invertibility. Furthermore, for the operators in the Wiener algebra $${\mathcal {W}}$$
W
invertibility, the Fredholm property and the Fredholm index are known to be independent of the underlying space $$l^p$$

l
p

, $$1\le p\le \infty $$

1
≤
p
≤
∞

. Here this is completed by the observation that even the kernel and a suitable direct complement of the range as well as generalized inverses of operators in $${\mathcal {W}}$$
W
are invariant w.r.t. p.
Extremal Values of the Sackin Tree Balance Index
Authors: Fischer Mareike 
Published: May 2021

AbstractTree balance plays an important role in different research areas like theoretical computer science and mathematical phylogenetics. For example, it has long been known that under the Yule model, a pure birth process, imbalanced trees are more likely than balanced ones. Also, concerning ordered search trees, more balanced ones allow for more efficient data structuring than imbalanced ones. Therefore, different methods to measure the balance of trees were introduced. The Sackin index is one of the most frequently used measures for this purpose. In many contexts, statements about the minimal and maximal values of this index have been discussed, but formal proofs have only been provided for some of them, and only in the context of ordered binary (search) trees, not for general rooted trees. Moreover, while the number of trees with maximal Sackin index as well as the number of trees with minimal Sackin index when the number of leaves is a power of 2 are relatively easy to understand, the number of trees with minimal Sackin index for all other numbers of leaves has been completely unknown. In this manuscript, we extend the findings on trees with minimal and maximal Sackin indices from the literature on ordered trees and subsequently use our results to provide formulas to explicitly calculate the numbers of such trees. We also extend previous studies by analyzing the case when the underlying trees need not be binary. Finally, we use our results to contribute both to the phylogenetic as well as the computer scientific literature using the new findings on Sackin minimal and maximal trees to derive formulas to calculate the number of both minimal and maximal phylogenetic trees as well as minimal and maximal ordered trees both in the binary and non-binary settings. All our results have been implemented in the Mathematica package SackinMinimizer, which has been made publicly available.
Does the insurance status influence in-hospital outcome? A retrospective assessment in 30,175 surgical trauma patients in Switzerland
Authors: Funke Lukas , Canal Claudio , Ziegenhain Franziska , Pape Hans-Christoph , Neuhaus Valentin 
Published: May 2021

Abstract
Introduction
There has been growing evidence in trauma literature that differences in insurance status lead to inequality in treatment and outcome. Most studies comparing uninsured to insured patients were done in the USA. We sought to gain further insights into differences in the outcomes of trauma patients in a healthcare system with mandatory public health coverage by comparing publicly versus privately insured patients.

Methods
We used a prospective national quality assessment database from the Arbeitsgemeinschaft für Qualitätssicherung in der Chirurgie (AQC). More than 80 surgical departments in Switzerland are part of this quality program. We included all patients in the AQC database with any S- or T-code diagnosis according to the International Classification of Diseases ICD-10 (any injuries) who were treated during the 11-year period of 2004–2014. Missing insurance status information was an exclusion criterion. In total, 30,175 patients were included for analysis. The primary outcome was in-hospital mortality. Secondary outcomes included overall and intra- and postoperative complications. Bi- and multivariate analyses were performed, adjusted for insurance status, age, sex, American Society of Anesthesiologists (ASA) physical status category, type of injury, and surgeon’s level of experience.

Results
In total, 76.8% (n = 23,196) of the patients were publicly insured. Patients with public insurance were significantly younger (p < 0.001), more often male (p < 0.001), and in better general health according to the ASA physical status category (p < 0.001). Length of pre- and postoperative stay and the number of operations per case were similar in the two groups. Patients with public insurance had a lower mortality rate (1.3% vs. 1.9%, p < 0.001), but after adjusting for confounders, insurance status was not a predictor of mortality. Overall complication rates were significantly higher for publicly insured patients (8.4% vs. 6.2%, p < 0.001), and after adjusting for confounders, insurance status was identified as an independent risk factor for overall complications (p < 0.001).

Conclusion
Differences exist with respect to patient and procedural characteristics: publicly insured patients were younger, more often male, and scored better on ASA physical status. Insurance status seems not to be a predictor for fatal outcome after trauma, although it is associated with complications.
Thermodynamic Implementations of Quantum Processes
Authors: Faist Philippe , Berta Mario , Brandao Fernando G. S. L. 
Published: May 2021

AbstractRecent understanding of the thermodynamics of small-scale systems have enabled the characterization of the thermodynamic requirements of implementing quantum processes for fixed input states. Here, we extend these results to construct optimal universal implementations of a given process, that is, implementations that are accurate for any possible input state even after many independent and identically distributed (i.i.d.) repetitions of the process. We find that the optimal work cost rate of such an implementation is given by the thermodynamic capacity of the process, which is a single-letter and additive quantity defined as the maximal difference in relative entropy to the thermal state between the input and the output of the channel. Beyond being a thermodynamic analogue of the reverse Shannon theorem for quantum channels, our results introduce a new notion of quantum typicality and present a thermodynamic application of convex-split methods.
Infrahepatic Inferior Vena Cava Clamping does not Increase the Risk of Pulmonary Embolism Following Hepatic Resection
Authors: Birgin Emrullah , Mehrabi Arianeb , Sturm Dorothée , Reißfelder Christoph , Weitz Jürgen , Rahbari Nuh N. 
Published: May 2021

AbstractBackgroundInfrahepatic inferior vena cava (IVC) clamping reduces central venous pressure. However, controversies remain regarding its impact on postoperative complications, particularly, the incidence of postoperative pulmonary embolism (PE). The aim of the study was to determine the impact of IVC clamping on the incidence of PE in patients undergoing hepatectomy.MethodsA pooled analysis of five prospective trials on patients who underwent hepatic resection over a period of 10 years was performed. Patients with infrahepatic IVC clamping were compared to patients without infrahepatic IVC clamping. Outcomes were studied by univariate and multivariate analyses.ResultsOf 505 included patients, 141 patients had IVC clamping and 364 patients served as control group. The rate of postoperative PE was comparable between groups (3% vs. 3%;P = 0.762), as were postoperative morbidity (P = 0.932), bile leakage (P = 0.272), posthepatectomy hemorrhage (P = 0.095), and posthepatectomy liver failure (P = 0.605), respectively. No clinicopathological and intraoperative risk factors were found to predict the onset of PE. Subgroup analyses of patients with major hepatectomy and vascular resections confirmed no adverse perioperative outcomes to be associated with IVC clamping.ConclusionsInfrahepatic IVC clamping does not increase the incidence of postoperative PE.
Variation in arterial input function in a large multicenter computed tomography perfusion study
Authors: Peerlings Daan , Bennink Edwin , Dankbaar Jan W. , Velthuis Birgitta K. , de Jong Hugo W. A. M. ,   On behalf of the DUtch acute STroke (DUST) study investigators, Majoie C. B. , Roos Y. B. , Duijm L. E. , Keizer K. , van der Lugt A. , Dippel D. W. , Droogh - de Greeve K. E. , Bienfait H. P. , van Walderveen M. A. , Wermer M. J. , Lycklama à Nijeholt G. J. , Boiten J. , Duyndam D. , Kwa V. I. , Meijer F. J. , van Dijk E. J. , Kesselring F. O. , Hofmeijer J. , Vos J. A. , Schonewille W. J. , van Rooij W. J. , de Kort P. L. , Pleiter C. C. , Bakker S. L. , Bot J. , Visser M. C. , Velthuis B. K. , van der Schaaf I. C. , Dankbaar J. W. , Mali W. P. , van Seeters T. , Horsch A. D. , Niesten J. M. , Biessels G. J. , Kappelle L. J. , Luitse M. J. , van der Graaf Y. 
Published: May 2021

Abstract
Objectives
To report the variation in computed tomography perfusion (CTP) arterial input function (AIF) in a multicenter stroke study and to assess the impact this has on CTP results.

Methods
CTP datasets from 14 different centers were included from the DUtch acute STroke (DUST) study. The AIF was taken as a direct measure to characterize contrast bolus injection. Statistical analysis was applied to evaluate differences in amplitude, area under the curve (AUC), bolus arrival time (BAT), and time to peak (TTP). To assess the clinical relevance of differences in AIF, CTP acquisitions were simulated with a realistic anthropomorphic digital phantom. Perfusion parameters were extracted by CTP analysis using commercial software (IntelliSpace Portal (ISP), version 10.1) as well as an in-house method based on block-circulant singular value decomposition (bSVD).

Results
A total of 1422 CTP datasets were included, ranging from 6 to 322 included patients per center. The measured values of the parameters used to characterize the AIF differed significantly with approximate interquartile ranges of 200–750 HU for the amplitude, 2500–10,000 HU·s for the AUC, 0–17 s for the BAT, and 10–26 s for the TTP. Mean infarct volumes of the phantom were significantly different between centers for both methods of perfusion analysis.

Conclusions
Although guidelines for the acquisition protocol are often provided for centers participating in a multicenter study, contrast medium injection protocols still vary. The resulting volumetric differences in infarct core and penumbra may impact clinical decision making in stroke diagnosis.

Key Points
• The contrast medium injection protocol may be different between stroke centers participating in a harmonized multicenter study.
• The contrast medium injection protocol influences the results of X-ray computed tomography perfusion imaging.
• The contrast medium injection protocol can impact stroke diagnosis and patient selection for treatment.
Novel loci and Mapuche genetic ancestry are associated with pubertal growth traits in Chilean boys
Authors: Vicuña Lucas , Norambuena Tomás , Miranda José Patricio , Pereira Ana , Mericq Veronica , Ongaro Linda , Montinaro Francesco , Santos José L. , Eyheramendy Susana 
Published: May 2021

AbstractPuberty is a complex developmental process that varies considerably among individuals and populations. Genetic factors explain a large proportion of the variability of several pubertal traits. Recent genome-wide association studies (GWAS) have identified hundreds of variants involved in traits that result from body growth, like adult height. However, they do not capture many genetic loci involved in growth changes over distinct growth phases. Further, such GWAS have been mostly performed in Europeans, but it is unknown how these findings relate to other continental populations. In this study, we analyzed the genetic basis of three pubertal traits; namely, peak height velocity (PV), age at PV (APV) and height at APV (HAPV). We analyzed a cohort of 904 admixed Chilean children and adolescents with European and Mapuche Native American ancestries. Height was measured on roughly a $$6-$$

6
-

month basis from childhood to adolescence between 2006 and 2019. We predict that, in average, HAPV is 4.3 cm higher in European than in Mapuche adolescents (P = 0.042), and APV is 0.73 years later in European compared with Mapuche adolescents (P = 0.023). Further, by performing a GWAS on 774, 433 single-nucleotide polymorphisms, we identified a genetic signal harboring 3 linked variants significantly associated with PV in boys (P$$< 5 \times 10^{-8}$$

<
5
×

10

-
8

). This signal has never been associated with growth-related traits.
Cephalometric analyses for cleft patients: a statistical approach to compare the variables of Delaire’s craniofacial analysis to Bergen analysis
Authors: Doberschütz Philine Henriette , Schwahn Christian , Krey Karl-Friedrich 
Published: May 2021

AbstractObjectivesCephalometric analyses using lateral craniofacial radiographs are common diagnostic procedures for evaluating skeletal patterns. However, in patients with pronounced abnormalities like cleft lip and palate, standard cephalometric analyses and landmarks may not be suitable. This study aims to clarify whether the inclusion of landmarks less compromised by the cleft defect or located outside the cleft area results in a different cephalometric assessment of the viscerocranium. Delaire’s whole-skull analysis and Bergen analysis were examined for similarities and underlying common observations.Materials/methodsBased on the cephalometric evaluation of 217 patients with different types of non-syndromal cleft formation, Delaire and Bergen analysis were compared using three statistical methods: correlation analysis, factor analysis, and cluster analysis. Reproducibility was assessed by Bland–Altman plots, intraclass correlation coefficients, mean absolute differences, and coefficients of variability.ResultsAlthough Delaire analysis and Bergen analysis are based on different concepts and landmarks, a majority of corresponding variables was found. Certain aspects of craniofacial base relation and craniospinal articulation are only assessed by Delaire analysis. All but one variable showed very good reproducibility.ConclusionsThe inclusion of landmarks less compromised by or located outside the cleft area does not result in variables that provide a different assessment of the viscerocranial area.Clinical RelevanceThe findings contradict the concept of invalidity of landmarks compromised by the cleft defect or located within the affected cleft area. Within the scope of its viscerocranial field of view, Bergen analysis appears to be on a par with Delaire analysis in the diagnosis of cleft patients.
Associating Ethos with Objects: Reasoning from Character of Public Figures to Actions in the World
Authors: Budzynska Katarzyna , Koszowy Marcin , Pereira-Fariña Martín 
Published: May 2021

AbstractEthotic arguments, such as arguments from expert opinion and ad hominem arguments, play an important role in communication practice. In this paper, we argue that there is another type of reasoning from ethos, in which people argue about actions in the world. These subspecies of ethotic arguments are very common in public debates: societies are involved in heated disputes about what should be done with monuments of historical figures such as Stalin or Colston: Should we demolish the building they funded? Should we revere their statues? Should the street named after them be renamed?; and the general public vividly argue about what should be done with the legacy of producers, directors and actors in debates of the #MeToo movement: Should their new movies be distributed? Should their scenes be deleted from motion pictures? Should their stars from the Hollywood Walk of Fame be removed? Many arguments in these debates boil down to the character of the public figures: He was a slave trader!—But he is a part of our history; He harassed a young girl!—But he is an important actor. The reasoning step here is legitimised by the association between a person and an extra-linguistic object: the association between a historical figure and their statue or between an actor and their movie. The nature of this association is explained in the paper using Peirce’s theory of signs. We propose to extend an existing approach to patterns of reasoning from ethos that will help us to shed new light on ethotic argumentation and open an avenue for a systematic account of these unexplored argument forms.
Pulmonary inflammation following intratracheal instillation of cellulose nanofibrils in rats: comparison with multi-walled carbon nanotubes
Authors: Fujita Katsuhide , Obara Sawae , Maru Junko , Endoh Shigehisa 
Published: May 2021

Abstract
Safety assessment of cellulose nanofibrils (CNFs) is required to accelerate the utilization of these materials in industrial applications. The present study aimed to characterize the effects on rat pulmonary inflammation over a period of 90 days following intratracheal instillation of three types of CNFs or multi-walled carbon nanotubes (MWCNTs) at doses of 0.5, 1.0, or 2.0 mg/kg. The pulmonary inflammatory responses induced by phosphorylated CNFs (CNF1), 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized CNFs (CNF2), CNFs produced via mechanical defibrillation (CNF3), and MWCNTs were investigated using bronchoalveolar lavage fluid analysis, histopathological findings, and comprehensive gene expression profiling of rat lungs. CNF1 and CNF2 with approximately equal diameter (7.0–8.0 nm) and length (0.8–1.0 µm) distributions induced inflammation after dosing, which was attenuated 90 days post-instillation. CNF3 of relatively greater thickness (21.2 nm) and longer length (1.7 μm) deposited around the terminal bronchioles were observed after instillation. Acute inflammatory responses in the alveoli induced by CNF3 were mild compared with those induced by other materials and attenuated 90 days post-instillation. MWCNTs induced severe pulmonary inflammatory responses that continued during the test period. The inflammation failed to resolve within 90 days post-instillation. A hierarchical cluster analysis revealed comparable gene expression profiles for CNF1, CNF2, and CNF3, whereas profiles of MWCNTs were different from those of other test substances. This study suggests that pulmonary inflammation is associated with the diameter and length distributions of CNFs and that the pulmonary inflammation caused by CNFs is mild compared with that caused by MWCNTs.

Graphic abstract
The conundrums of formal and informal meritocracy: dealing with gender segregation in the academy
Authors: Powell Stina , Arora-Jonsson Seema 
Published: May 2021

AbstractDespite the academy’s commitment to the idea of meritocratic and fair principles in recruitments, promotions, student admissions and progress, gender segregation and gender inequalities continue to trouble universities worldwide. Through case-studies of two education programs at a Swedish university, we investigate how processes of formal merit, both formal (required for admission such as high grades) and what we identify as informal merit (needing to act in particular ways once admitted) work to obviate or reproduce gender-segregation. We analyze how everyday gendering processes in the classroom play a central role in what gets constructed as merit. Changing notions of merit during the period of study can hamper possibilities for ending gender segregation in HE or open up for ways to circumvent it. We show that a complex and ongoing construction of informal merit can restrain students from minority groups (in relation to gender, but also ethnic background, socioeconomic position, or sexuality) to enter, and importantly, remain in the program. At the same time, new ways of addressing the subject itself provides potential openings. We argue that in order to achieve gender balance at universities, it is urgent to understand how informal and formal merit interplay once students have joined the university and importantly also when they have made the leap and broken with gender segregated education choices.
Human actions were responsible for both initiation and termination of varve preservation in Lake Vesijärvi, southern Finland
Authors: Salminen Sarianna , Tammelin Mira , Jilbert Tom , Fukumoto Yu , Saarni Saija 
Published: May 2021

AbstractThe influence of lake restoration efforts on lake bottom-water conditions and varve preservation is not well known. We studied varved sediments deposited during the last 80 years along a water-depth transect in the Enonsaari Deep, a deep-water area of the southernmost Enonselkä Basin, Lake Vesijärvi, southern Finland. For the last few decades, the Enonselkä Basin has been subject to ongoing restoration efforts. Varve, elemental, and diatom analyses were undertaken to explore how these actions and other human activities affected varve preservation in the Enonsaari Deep. In contrast to most varved Finnish lakes, whose water columns have a natural tendency to stratify, and possess varve records that span thousands of years, varve formation and preservation in Lake Vesijärvi was triggered by relatively recent anthropogenic stressors. The multi-core varve analysis revealed that sediment in the Enonsaari Deep was initially non-varved, but became fully varved in the late 1930s, a time of increasing anthropogenic influence on the lake. The largest spatial extent of varves occurred in the 1970s, which was followed by a period of less distinguishable varves, which coincided with diversion of sewage from the lake. Varve preservation weakened during subsequent decades and was terminated completely by lake aeration in the 2010s. Despite improvements in water quality, hypolimnetic oxygen depletion and varve preservation persisted beyond the reduction in sewage loading, initial aeration, and biomanipulation. These restoration efforts, however, along with other human actions such as harbor construction and dredging, did influence varve characteristics. Varves were also influenced by diatom responses to anthropogenic forcing, because diatoms form a substantial part of the varve structure. Of all the restoration efforts, a second episode of aeration seems to have had the single most dramatic impact on profundal conditions in the basin, resulting in replacement of a sediment accumulation zone by a transport or erosional zone in the Enonsaari Deep. We conclude that human activities in a lake and its catchment can alter lake hypolimnetic conditions, leading to shifts in lake bottom dynamics and changes in varve preservation.