bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of an Autophagy-Related Gene Prognostic Risk Model Based on TCGA Database in Cervical Cancer
Authors: Shi Huadi , Zhong Fulan , Yi Xiaoqiong , Shi Zhenyi , Ou Feiyan , Xu Zumin , Zuo Yufang 
Published: February 2021

Background: Autophagy plays an important role in the development of cancer. However, the prognostic value of autophagy-related genes (ARGs) in cervical cancer (CC) is unclear. The purpose of this study is to construct a survival model for predicting the prognosis of CC patients based on ARG signature.Methods: ARGs were obtained from the Human Autophagy Database and Molecular Signatures Database. The expression profiles of ARGs and clinical data were downloaded from the TCGA database. Differential expression analysis of CC tissues and normal tissues was performed using R software to screen out ARGs with an aberrant expression. Univariate Cox, Lasso, and multivariate Cox regression analyses were used to construct a prognostic model which was validated by using the test set and the entire set. We also performed an independent prognostic analysis of risk score and some clinicopathological factors of CC. Finally, a clinical practical nomogram was established to predict individual survival probability.Results: Compared with normal tissues, there were 63 ARGs with an aberrant expression in CC tissues. A risk model based on 3 ARGs was finally obtained by Lasso and Cox regression analysis. Patients with high risk had significantly shorter overall survival (OS) than low-risk patients in both train set and validation set. The ROC curve validated its good performance in survival prediction, suggesting that this model has a certain extent sensitivity and specificity. Multivariate Cox analysis showed that the risk score was an independent prognostic factor. Finally, we mapped a nomogram to predict 1-, 3-, and 5-year survival for CC patients. The calibration curves indicated that the model was reliable.Conclusion: A risk prediction model based on CHMP4C, FOXO1, and RRAGB was successfully constructed, which could effectively predict the prognosis of CC patients. This model can provide a reference for CC patients to make precise treatment strategy.
Pain Relief Dependent on IL-17–CD4+ T Cell–β-Endorphin Axis in Rat Model of Brachial Plexus Root Avulsion After Electroacupuncture Therapy
Authors: Xu Zihang , Zhu Yangzhuangzhuang , Shen Jun , Su Lin , Hou Yifei , Liu Mingxi , Jiao Xiaoning , Chen Xiao , Zhu Shiguo , Lu Yechen , Yao Chao , Wang Lixin , Gong Chenyuan , Ma Zhenzhen , Zou Chunpu , Xu Jianguang 
Published: February 2021

Background and purposeNeuropathic pain is the typical symptom of brachial plexus root avulsion (BPRA), and no effective therapy is currently available. Electroacupuncture (EA), as a complementary and alternative therapy, plays a critical role in the management of pain-associated diseases. In the present study, we aimed to reveal the peripheral immunological mechanism of EA in relieving the pain of BPRA through the IL-17–CD4+ T lymphocyte–β-endorphin axis.MethodsAfter receiving repeated EA treatment, the pain of BPRA in rats along with the expressions of a range of neurotransmitters, the contents of inflammatory cytokines, and the population of lymphocytes associated were investigated. CD4+ T lymphocytes were either isolated or depleted with anti-CD4 monoclonal antibody. The titers of IL-17A, interferon-γ (IFN-γ), and β-endorphin were examined. The markers of T lymphocytes, myeloid-derived suppressor cells (MDSCs), dendritic cells (DCs), macrophages, and natural killer (NK) cells were assessed. The activation of the nuclear transcription factor κB (NF-κB) signaling pathway was tested.ResultsThe pain of BPRA was significantly relieved, and the amount of CD4+ T lymphocytes was increased after EA treatment. The release of β-endorphin was up-regulated with the up-regulation of IL-17A in CD4+ T lymphocytes. The titer of IL-17A was enhanced, leading to an activated NF-κB signaling pathway. The release of β-endorphin and the analgesic effect were almost completely abolished when CD4+ T lymphocytes were depleted.ConclusionWe, for the first time, showed that the neuropathic pain caused by BPRA was effectively relieved by EA treatment via IL-17–CD4+ T lymphocyte–β-endorphin mediated peripheral analgesic effect, providing scientific support for EA clinical application.
China Multi-Center Preschool Autism Project (CMPAP): Design and Methodologies to Identify Clinical Symptom Features and Biomarkers of Autism Spectrum Disorders
Authors: Yang Ting , Zhu Jiang , Li Qiu , Chen Li , Wu Li-Jie , Jia Fei-Yong , Hao Yan , Ke Xiao-Yan , Yi Ming-Ji , Jin Chun-Hua , Chen Jie , Li Ting Yu 
Published: February 2021

Background: The etiology of autism spectrum disorder (ASD) has not yet been fully identified, but it seems to be triggered by complex genetic and environmental risk factors. Moreover, the tremendous etiological and clinical differences among individuals with ASD has had a major negative impact on early diagnosis and individualized treatment. Earlier diagnosis of precise clinical subtypes of ASD could lead to individualized treatment and a better prognosis. However, few large-scale epidemiological studies have explored precise clinical subtypes and clinically meaningful biomarkers, especially in China.Methods and Design: The China Multi-center Preschool Autism Project (CMPAP) includes nearly 3,000 children−1,469 individuals with ASD and 1,499 typically-developing (TD) controls—from 13 cities in China. Using a case-control design, each participant was comprehensively characterized in terms of feeding and disease history, maternal history, family history, clinical core symptoms, comorbidities, biochemical markers, genomics, urine/fecal metabonomics, and intestinal flora. In addition, data on environmental risk factors were obtained using interviews and electronic medical records.Conclusion: The study was designed to: (1) investigate age at diagnosis and treatment and family and social support for preschool children with ASD in China, (2) develop a more accurate clinical subtype and intervention system for the ICD-11, and (3) find the specific genes and environmental markers of different subtypes, which will help in the development of early diagnosis and individual intervention programs for preschool children with ASD. This study will provide the basis for improving national health policies for ASD in China.
Satisfaction With Life, Mental Health Problems and Potential Alcohol-Related Problems Among Norwegian University Students
Authors: Jensen Pia , Haug Ellen , Sivertsen Børge , Skogen Jens Christoffer 
Published: February 2021

Objective: Recent studies have shown that today's college students more than ever are struggling with mental health and alcohol problems. While poor satisfaction with life and mental health problems have been linked to higher alcohol consumption, there is still a lack of studies examining in detail the shape and nature of the relationship between mental health and alcohol consumption.Aim: To investigate the associations between satisfaction with life, mental health problems and potential alcohol-related problems among Norwegian university students. The shape of the associations was also examined.Methods: Data were drawn from a 2018 national survey of students in higher education in Norway (the SHoT-study). Associations between satisfaction with life, mental health problems and potential alcohol-related problems (AUDIT; risky and harmful alcohol use) were investigated using logistic regression. Both crude models and models adjusted for age, gender and marital status were conducted. To investigate the shape of the associations, logistic regression with quadric and cubic terms was tested.Results: Decreased satisfaction with life and increased mental health problems were associated with potential alcohol-related problems. For satisfaction with life, a curvilinear association with risky alcohol use and a linear association with harmful alcohol use was identified. For mental health problems, curvilinear associations were found for both risky and harmful alcohol use.Conclusion: Many students report potential alcohol-related problems. Students with harmful alcohol use seem to be more at risk of reduced satisfaction with life and increased mental health problems than students with risky alcohol use. Educational institutions may be an ideal setting for raising awareness of mental health issues and responsible alcohol consumption among students. The present study contributes with important information about the shape of the associations between satisfaction with life, mental health problems and potential alcohol-related problems in the student population.
Tradisi Bhen-Ghiben Pada Perkawinan Adat Madura; Studi Kasus Di Kabupaten Sumenep-Madura
Authors: Susantin Jamiliya , Rijal Syamsul 
Published: February 2021

Abstrak:
Tradisi ben-ghiben adalah tradisi membawa barang oleh pengantin pria kerumah penganten wanita berupa alat-alat rumah tangga, yakni lemari, kursi, tempat tidur, dan semua jenis perlengkapan dapur. Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis tentang tradisi ben-ghiben perkwinan adat Madura. Adapun metodeloginya adalah kualitatif dengan tahapan penelitian observasi, wawancara dan dokumentasi. Untuk analisis data dengan menggunakan analisis deskriptif-fenomelogis. Hasil dari penelitian adalah tradisi perkawinan di Madura berbeda dengan Tradisi perkawinan di jawa, kalau di Madura menganut mayoritas menganut tradisi matrilineal, dimana suami-istri setelah melangsungkan perkawinan dituntut untuk tinggal dirumah istri. Dan calon suami membawa bhen-gibhen (barang bawaan berupa lemari, kursi, tempat tidur dan perabotan rumah tangga lainnya). Dan istri menyediakan rumah untuk ditempati.

Kata Kunci: Tradisi, Ben-Ghiben, Perkawinan, Madura

Abstract:
The ben-ghiben tradition is the tradition of bringing items by the groom to the bride's house in the form of household items, namely cabinets, chairs, beds, and all kinds of kitchen utensils. The purpose of this research is to know and analyze the tradition of ben-ghiben Madurese traditional marriage. The methodology is qualitative with the research stages observation, interviews and documentation. For data analysis using descriptive-phenomelogical analysis. The result of the research is that the tradition of marriage in Madura is different from the tradition of marriage in Java, if in Madura the majority adheres to the matrilineal tradition, where the husband and wife after marriage are required to stay at the wife's house. And future husbands bring bhen-gibhen (luggage in the form of cabinets, chairs, beds and other household furniture). And the wife provides a house to live in.

Keywords: Tradition, Bhen-gibhen, Marriage, Madura
Kondisi Ketenagakerjaan; Kesempatan Kerja Dan Penyerapan Tenaga Kerja Industri Masyarakat Lokal Pada Wilayah Desa Berbasis Industri
Authors: Khumaidi Khumaidi , Sunarno Heri 
Published: February 2021

Abstrak:
Penelitian ini dilatarbelakangi adanya amanat regulasi yaitu Peraturan Daerah Kabupaten Pasuruan Nomor 22 Tahun 2012 tentang Sistem Penyelenggaraan Ketenagakerjaan di Kabupaten Pasuruan, khususnya kesempatan kerja dan penyerapan tenaga kerja industri dari masyarakat lokal atau masyarakat sekitar dimana industri itu berada. Penelitian ini merupakan penelitian deskriptif kualitatif, dimana data dikumpulkan melalui observasi, wawancara dan pengumpulan dokumen. Kemudian dianalisa dengan model interaktif. Untuk lebih menguatkan hasil penelitian ini digunakan model triangulasi. Hasil penelitian menjelaskan bahwa kondisi ketenagakerjaan terkait kesempatan kerja yaitu masyarakat lokal atau masyarakat sekitar industri berdomisili memiliki kesempatan kerja sebesar 65,53% memiliki kesempatan/ peluang kerja. Sedangkan kondisi ketenagakerjaan, khususnya penyerapan tenaga kerja yaitu masyarakat lokal atau masyarakat sekitar industri berdomisili memiliki kesempatan kerja sebesar 20,80% terserap atau memenuhi permintaan tenaga kerja industri.

Kata Kunci: Ketenagakerjaan, Penyerapan Tenaga Kerja Industri

Abstract:
This research is motivated by a regulatory mandate, namely the Pasuruan Regency Regional Regulation Number 22 of 2012 concerning the Manpower Implementation System in Pasuruan Regency, in particular employment opportunities and absorption of industrial labor form local communities or local communinities where the industry is local. This research is a qualitative descriptive study, where data is collected through observation, interviews and document collection. then analyzed with an interactive model. To further strengthen the results of this study a triangulation model is used. The results of the study explained that the labor conditions related to job opportunities, namely local communities or communities around the industrial area where they are domiciled have a job opportunity of 65.53% have a job opportunity. Meanwhile, the employment conditions, in particular the absorption of labor, namely local communities or communities around the domiciled industry have a job opportunity of 20.80% absorbed or fulfilling the demand for industrial labor.

Keywords: Employment, Industrial Labor Absorption
Urgensi Pembentukan Peraturan Desa Tentang Pengelolaan Wisata Syariah Dalam Meningkatkan Kemandirian Ekonomi Kabupaten Sumenep
Authors: Syamsi Achmad Badarus , Adiyono Adiyono 
Published: February 2021

Abstrak:
Konsep pariwisata halal diharapkan bisa meningkatkan jumlah wisman di objek-objek wisata tersebut. Konsep pariwisata halal diambil karena dilihat dari sisi sosial budaya agama masyarakatnya, banyaknya pondok pesantren, obyek wisata religi, dan kesenian Islam. Disisi lain Kepastian hukum merupakan hal yang sangat urgen untuk menarik minat investor dan wisatawan. Disinilah urgensi dari keberadaan legalitas pariwisata halal. Tujuan dari Penelitian ini pertama adalah untuk mengemukakan bentuk pengaturan pariwisata halal yang sudah diterapkan di beberapa daerah di Indonesia. Kedua akan berupaya untuk menemukan model pengaturan yang efektif, efisien dan mempunyai kepastian hukum yang tinggi untuk diterapkan di Sumenep. Penelitian ini merupakan penelitian pustaka dengan pendekatan kualitatif deskriptif, yang berusaha untuk memaparkan tujuan penelitian di atas. Sumber data yang digunakan adalah ketentuan mengenai pembuatan peraturan perundang-undangan dan peraturan pariwisata halal di Indonesia. Adapun hasil dari penelitian ini adalah penemuan sebuah model atau bentuk peraturan tentang pariwisata halal di Sumenep yang efektif, efisien dan mempunyai kepastian hukum yang tinggi.

Kata Kunci: legalitas, pariwisata halal, prinsip syariah

Abstract:
The concept of halal tourism is expected to increase the number of foreign tourists in these tourist objects. The concept of halal tourism is taken because it is seen from the socio-cultural side of the community, the number of Islamic boarding schools, religious tourism objects, and Islamic arts. This is where the urgency of the legality of halal tourism. The purpose of this research The first is to give shape halal tourism arrangement that has been applied in several regions in Indonesia. Both will attempt to find a model setting of effectif eficient and have a high supremacy of law to be applied in Sumenep. This research is a literature research with a qualitative deskriptif approach, that seeks to explain the purpose of its research. The sources data that used is provisions about rule making and regulations halal tourism in Indonesia. The resault of this research is discovery of a model or form regulations on tourism kosher in Sumenep effective, efficient and have a high supremacy of law.

Keywords: legality, halal tourism, sharia principles.
Inovasi Kepemimpinan Kepala Madrasah Tsanawiyah Negeri 3 Pamekasan
Authors: Ulum Nurul 
Published: February 2021

Abstrak:
Kepala madrasah memiliki peran yang strategis untuk mengembangkan madrasah yang dipimpinnya. Kepala madrasah harus memiliki kompetensi tertentu yang dapat mendukung terhadap pelaksanaan tugas dan fungsinya sebagai pemimpin di madrasah. Dengan sejumlah kompetensi tersebut seorang kepala madrasah dapat menerapkan berbagai inovasi untuk mengembangkan madrasah yang ia pimpin. Riset ini menggunakan pendekatan kualitatif yang objeknya MTsN 3 Pamekasan yang terletak di Desa Pakong. Teknik analisis data yang digunakan adalah flow model analysis ala Miles dan Huberman yang meliputi pengumpulan data, reduksi data, display data dan verifikasi. Hasil dari riset ini yaitu pertama, bentuk inovasi kepemimpinan kepala madrasah berupa membangun brand image madrasah edukotourism, inovasi kurikulum, inovasi proses, inovasi layanan SKS dan inovasi pola hubungan. Kedua, strategi yang ditempuh kepala madrasah dalam melaksanakan inovasi yaitu strategi fasilitatif, strategi persuasif, strategi pendidikan, strategi paksaan dan strategi uswatun hasanah (keteladanan). Ketiga, kendala yang dihadapi MTs Negeri 3 Pamekasan dalam menerapkan inovasi yaitu kendala di bidang pendanaan, kendala sumber daya manusia dan kendala sarana prasarana.

Kata kunci: Inovasi, Kepemimpinan, Edukotourism, Kepala Madrasah

Abstract:
The madrasa head has a strategic role to develop the madrasa he leads. Madrasa head must have certain competencies that can support the implementation of his duties and functions as leader in the madrasa. Wiith these competencies, a madrasa head can apply various innovations to develop the madrasa he leads. This research used a qualitative approach whose object is MTs Negeri 3 Pamekasan located in Pakong Village. The data analysis technique used is Miles and Huberman’s flow model analysis which includes data collection, data reduction, data display and verification. The results of this research are firstly build brand image of madrasa educotourism, curriculum innovation, process innovation, SKS service innovation, and relationship pattern innovation, secondly, the strategy adapted by the madrasa head in implementing innovations, namely facilitative strategies, persuasive strategies, educational strategies, coercive strategies and uswatun hasanah ( exemplary) strategies, third, the constraints faced by MTs Negeri 3 Pamekasan in implementing innovation, namely constraints in the field of funding, human resource constraints and infrastructure constraints.

Keywords: Innovation, Leadership, Educotourism, Headmaster
Crimen desorganizado y mercados ilegales de droga en la ciudad de Rosario
Authors: Iazzetta Marco 
Published: February 2021

El presente trabajo tiene por objeto polemizar con las representaciones que circulan en muchos artículos periodísticos y académicos que abordan la problemática criminal. Al respecto, se procura dar cuenta del caos, la incertidumbre, las maniobras incesantes, improvisadas y abruptas que caracterizan muchas veces al accionar del llamado crimen organizado, en especial, cuando su actividad se establece en torno al mercado ilegal de drogas.
A los efectos, nos centramos en la situación de la ciudad de Rosario para destacar algunos aspectos generales del proceso de estructuración de los grupos criminales en función de dicho negocio, las lógicas comerciales que lo atraviesan, la gran variedad de actores y la forma en la que hacen uso de la violencia.
Clima laboral y satisfacción laboral en los docentes de una universidad pública y una privada
Authors: Alegre Morales Ana , Barrientos Montellanos Rocío , Milla Rotta Marilú 
Published: February 2021

La presente investigación tuvo el objetivo de analizar la relación entre el clima y la satisfacción laboral en docentes de una universidad pública y una privada. La muestra fue de 62 docentes de la Universidad Federico Villarreal y 38 docentes de la Universidad Champagnat, a quienes se les aplicó el Cuestionario de Clima Laboral (CLA) y el Cuestionario de Satisfacción Laboral versión S20/23. Se halló que los docentes de institución privada tienen mejor clima laboral que los de institución pública (p = .000) y también presentan mayor satisfacción laboral (p = .000). Además, los resultados indicaron que existen una relación significativa entre las variables de estudio solamente en la institución privada (p = .003).
La marginal desigualdad: la desigualdad social como fantasía de y para el consumo
Authors: Coriñaupa Vargas Francisco Augusto 
Published: February 2021

Cuando se trata de desigualdad social y marginalidad, habitualmente hacemos alusión al chiste irónico arriba colocado, no obstante y aunque suene a chiste, es lo que se persigue en el fondo, en un afán por lograr una igualdad inexistente entre individualidades. En ese sentido cabe cuestionar, en qué medida la llamada desigualdad social o la marginalidad pueden existir, ya que al estar inmersos bajo un imperativo de consumo, bajo el cual nada escapa a la esfera de lo económico y a la idea de “desarrollo” –aunque este también sea un término sospechoso, ya que su definición depende de los tiempos y del lugar en que se vive – que se maneja en esta parte del mundo, se puede afirmar que nada escapa a la impronta capitalista, por lo que se transforma en medida de todas las cosas socialmente aceptadas, incluso consideradas “normales”, si es que acaso se puede hablar de eso.
Educación inclusiva en México: de la teoría a la práctica
Authors: Mendoza Méndez Luz Areli 
Published: February 2021

Actualmente en México, se aborda el tema de trabajar con la diversidad bajo un enfoque de educación inclusiva. Sin embargo, ¿cómo se está llevando a cabo? En el siguiente texto se abordan algunos de los fundamentos legales y normativos de la educación inclusiva, desde la perspectiva de un docente de apoyo, así como una reflexión acerca de lo que nos propone la teoría y lo que sucede en las escuelas.
Overview of the Occurrence and Prevention of Bemisia tabaci Invasion in China
Authors: Liu Shunxiao , Yu Hao , V.A Vlasenko 
Published: February 2021

Biological invasion refers to the process of invading into another new environment through natural or man-made means from the original place of existence,which includes several stages of introduction, colonization, incubation, diffusion and outbreak.Bemisia tabaci is a worldwide important agricultural pest composed of multiple biotypes. Studies have confirmed that the B biotype Bemisia tabaci that invaded China has been genetically differentiated, and the Q biotype Bemisia tabaci has replaced the B biotype in most areas of China. Bemisia tabaci has become the dominant biotype in the field.
Pemilihan Penolong Persalinan pada Ibu yang Telah Mengikuti Kelas Ibu Hamil di Puskesmas Garuda dan Puskesmas Pasundan Kota Bandung
Authors: Nuurjannah Febri Annisaa 
Published: February 2021

Salah satu terobosan dalam menurunkan AKI adalah dengan diadakannya program Perencanaan Persalinan dan Pencegahan Komplikasi (P4K) yang mampu meningkatkan cakupan pertolongan persalinan oleh tenaga kesehatan. Di dalam P4K salah satu programnya yaitu Kelas Ibu Hamil. Program ini bertujuan untuk meningkatkan pengetahuan dan mengubah perilaku ibu hamil dan keluarga. Penelitian ini bertujuan untuk mengetahui pemilihan penolong persalinan dari ibu yang telah mengikuti kelas ibu hamil di Puskesmas Garuda dan Puskesmas Pasundan Kota Bandung. Deskriptif dengan pendekatan cross sectional, menggunakan data primer yang dikumpulkan dengan metode survei melalui kuesioner yang disebarkan pada tanggal 26-28 Juni 2012 terhadap 30 orang ibu. Didapatkan bahwa gambaran karakteristik ibu nifas yang telah mengikuti kelas ibu hamil yaitu berumur 20-35 tahun sebanyak 80%, berpendidikan SMA sebanyak 56, 67%, tidak bekerja sebanyak 96, 67%, dan paritas 2-3 sebanyak 70%. Ibu nifas yang memiliki pengetahuan baik, tentang persalinan yang aman sebanyak 66,67% dan ibu nifas yang memilih penolong persalinan oleh tenaga kesehatan sebanyak 90%. Simpulan penelitian ini adalah pemilihan penolong persalinan pada ibu nifas yang telah mengikuti kelas ibu hamil sebagian besar ditolong oleh tenaga kesehatan (dokter atau bidan).