bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preterm Birth, Maternal Postpartum Depressive Symptoms and Mental and Behavioral Disorders in Children
Authors: Girchenko Polina , Robinson Rachel , Rantalainen Ville Juhani , Lahti-pulkkinen Marius , Heinonen-Tuomaala Kati , Lemola Sakari , Wolke Dieter , Schnitzlein Daniel , Hamalainen Esa , Laivuori Hannele , Villa Pia , Kajantie Eero , Raikkonen Katri 
Published: July 2021

Abstract
Introduction Preterm birth has been linked with postpartum depressive (PPD) disorders and high symptoms levels, but evidence remains conflicting and limited in quality. It remains unclear whether PPD symptoms of mothers with preterm babies were already elevated before childbirth, and whether PPD symptoms mediate/aggravate the effect of preterm birth on child mental disorders. We examined whether preterm birth associated with maternal PPD symptoms, depressive symptoms trajectories from antenatal to postpartum stage, and whether PPD symptoms mediated/aggravated associations between preterm birth and child mental disorders. Methods Mothers of preterm(n=125) and term-born(n=3033) children of the Prediction and Prevention of Preeclampsia and Intrauterine Growth Restriction study reported depressive symptoms four times within 8 weeks before and twice within 12 months after childbirth. Child mental and behavioral disorder diagnoses until age 8.4-12.8 years came from medical register. ResultsPreterm birth associated with higher PPD symptoms(MD=0.19 SD,95%CI 0.01,0.37,p=0.04), and higher odds(OR=2.23,95%CI 1.22,4.09,p=0.009) of the mother to belong to a group that had consistently high depressive symptoms levels trajectory from antenatal to postpartum stage. PPD symptoms partially mediated and aggravated the association between preterm birth and child mental disorders. ConclusionsPreterm birth, maternal PPD symptoms and child mental disorders are associated, calling for timely prevention interventions.
Anti-Gr-1 Antibody Provides Short-term Depletion of MDSC in Lymphodepleted Mice With Active-specific Melanoma Therapy
Authors: Rose Peter , Engel Natasja K. van den , Kovacs Julia R. , Hatz Rudolf A. , Boon Louis , Winter Hauke 
Published: July 2021

Abstract

BackgroundLymphodepletion, reconstitution and active-speciﬁc tumor cell vaccination (LRAST) enhances the induction of tumor-speciﬁc T cells in a murine melanoma model. Myeloid-derived suppressor cells (MDSC, Gr-1+ CD11b+) may counteract the induction of tumor-reactive T cells and their therapeutic eﬃcacy. Thus, the aim of the study was to evaluate a possible beneﬁt of MDSC depletion using anti-Gr-1 antibodies (Ab) in combination with LRAST.MethodsFemale C57BL/6 mice with 3 days established subcutaneous (s.c.) D5 melanoma were lymphodepleted with cyclophosphamide and reconstituted with naive splenocytes. Vaccination was performed with irradiated syngeneic mGM-CSF-secreting D5G6 melanoma cells. For MDSC depletion, anti-Gr-1 Ab (clone RB6-8C5, 230 µg) was injected every other day starting on the day of lymphodepletion. Induction of tumor-speciﬁc T cells derived from tumor vaccine draining lymph nodes (TVDLN) was evaluated by the amount of tumor-specific interferon (IFN)- γ release. Tumor growth was monitored following active-specific vaccination with or without anti-Gr-1 Ab administration.ResultsLRAST combined with anti-Gr-1 mAb administration enhanced the induction of tumor-specific T cells in TVDLN capable of releasing IFN-γ in a tumor-specific manner. In mice treated with LRAST and anti-Gr-1 mAb growth of D5 melanoma cells was significantly delayed for two weeks following tumor injection as compared to mice with LRAST treatment alone. Furthermore, we elucidate the impact of anti-Gr-1 depleting antibodies on the memory T cell compartment.ConclusionOur data indicate that standard of care treatment regimens against cancer can be improved by implementing agents, e.g. depleting antibodies, which target and eliminate MDSC.
Contingency Response Decision of Network Public Opinion Emergencies based on Intuitionistic Fuzzy Entropy and Preference Information of Decision Makers
Authors: Fu Sha , Xiao Ye-zhi , Zhou Hang-jun 
Published: July 2021

Abstract
A multi-attribute group decision-making (MAGDM) method based on intuitionistic fuzzy preference information is proposed for the multi-attribute intuitionistic fuzzy group decision-making problem where the decision-makers weight and attribute weight are completely unknown and the decision-maker has preference information for the scheme. Firstly, an intuitionistic fuzzy interval judgment matrix is established to describe the original data of the key decision indicators for multiple network public opinion emergencies that erupt simultaneously. Secondly, the attribute weights are determined based on the improved intuitionistic fuzzy entropy construction method, and the expert weights are determined by using objective decision information, taking into account the intuitionistic fuzzy entropy of decision matrix. Thirdly, a scheme preference model and an attribute weight optimization model are established to determine the ranking method of intuitionistic fuzzy interval values. Then, an improved intuitionistic fuzzy number distance measure is introduced to make the evaluation result more accurate and reasonable when it comes to solving the deviation between the evaluation value and ideal solution of each scheme. Finally, the effectiveness and practicability of the proposed decision-making method are verified by an example of emergency crisis severity, which improves the efficiency of emergency treatment, helps emergency departments to better deal with the network public opinion crisis, improves the ability of public opinion guidance and control, and provides a new method and idea for multi-attribute intuitionistic fuzzy group decision-making problem.
Dynamic Update Method of Working Face Geological Model Driven by Multi-Source Data
Authors: Liu Zaibin , Li Mingxing , An Lin , Shen Kai , Yue Hui , Chen Baohui , Zhu Mengbo , Gong Yingying 
Published: July 2021

Abstract
In order to build a high-precision dynamic geological model to serve the intelligent mining, working face is explored step by step through the comprehensive prospecting technology. A multi-source data fusion method was applied to realize mutual verification, supplement, fusion and interpretation of non-uniform heterogeneous geological data to obtain a high-precision geological data volume. Also, the dynamic update model method was proposed to update 3D geological model of working face quickly so that the accuracy of the geological model can be improved effectively. Furthermore, cutting path planning technology was developed based on the dynamic geological model. The field test showed that the cutting path planning based on the high-precision dynamic geological model can improve the coal mining efficiency and improve the fusion efficiency between geology and coal mining systems. Dynamic update of multi-attribute geological information should be studied and developed to improve the automatic level of mining driven by geological data.
Narciclasine Targets STAT3 via Distinct Mechanisms in Tamoxifen-Resistant Breast Cancer Cells
Authors: Lv Chao , Huang Yun , Huang Rui , Wang Qun , Zhang Hongwei , Jin Jinmei , Lu Dong , Zhou Yudong , Shen Yunheng , Zhang Weidong , Luan Xin , Liu Sanhong 
Published: July 2021

Abstract
Background: Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in multiple malignant tumors. Compared with regular estrogen receptor (ER)-positive breast cancers, the patients with tamoxifen-resistant breast cancers often exhibit higher level of STAT3 phosphorylation. Narciclasine (Nar) possesses strong inhibiting effects against a variety of cancer cells, however, the underlying antitumor target(s)/mechanism(s) remains barely understood. Methods: Targets prediction of narciclasine was performed by combining connectivity map (CMAP) and drug affinity responsive target stability (DARTS) strategy. Molecular and biochemical methods were used to elucidate the distinct mechanisms of narciclasine targeting STAT3. The narciclasine nano-delivery system was synthesized by thin film hydration method. Xenograft models were established to determine antitumor activity of narciclasine and its liposome in vivo.Results: In this study, we successfully identified the STAT3 was the direct target of Nar through the combination strategies of CMAP and DARTS. In ER-positive breast cancer cells, Nar could suppress phosphorylation, activation, dimerization, and nuclear translocation of STAT3 by directly binding with the STAT3 SH2 domain. Additionally, Nar could also specifically promote total STAT3 degradation via proteasome pathway and reduce the STAT3 protein stability in tamoxifen-resistant breast cancer cells (MCF-7/TR). This distinct mechanism of Nar targeting STAT3 was mainly attributed to the various levels of reactive oxygen species (ROS) in regular and tamoxifen-resistant ER-positive breast cancer cells. Meanwhile, Nar loaded nanoparticles could markedly decrease the protein levels of STAT3 in tumor sites, resulting in significant MCF-7/TR xenograft tumor regression without obvious toxicity. Conclusions: Our findings successfully highlight the STAT3 as the direct therapeutic target of Nar in ER-positive breast cancer cells, especially Nar leaded STAT3 degradation as a promising strategy for the tamoxifen-resistant breast cancer treatment.
Have Progestin Related and Sporadic High Grade Meningiomas the Same Natural History?
Authors: Devalckeneer Antoine , Aboukais Rabih , Faisant Maxime , Bourgeois Philippe , Quentin Vannod-Michel , Escande Fabienne , Maurage Claude-Alain , Lejeune Jean-Paul 
Published: July 2021

Abstract
Introduction: High grade progestin related meningiomas have been reported in recent series but we found no previous study describing their long-term outcome. Our study aimed to evaluate patients operated on for high grade intracranial meningioma and who underwent long term exposure to high dose of cyproterone acetate, nomegestrol acetate and chlormadinone acetate.Methods: Our study retrospectively included 9 patients with high grade progestin related intracranial meningioma between December 2006 and December 2020. In each patient, clinico-radiological follow-up was performed every 6 months after diagnosis and treatment withdrawal recommendation. Results: The mean progestative exposure was 11.4 years. Edema existence or absence of cleft sign on MRI were the key factors for surgical indication. All patients underwent surgery. Ajduvant radiotherapy was indicated in 1 patient, and Gamma Knife Radiosurgery was proposed in 2 other patients for a second location of mengioma. 6 patients harbored a grade II chordoïd meningioma subtype with 100% PR expression and 3 patients a grade II atypical meningioma subtype with lower PR expression. The mean follow-up was 7.1 years and none of the 9 patients presented with a recurrence.Conclusion: Patients with Grade II progestin related meningiomas have less tumor recurrence after surgery than patients with sporadic high grade meningomas, especially after progestin withdrawal. The presence/ appearance of peri-meningioma edema and the absence of cleft sign before volumetric change should suggest the existence of an underlying high grade meningioma. In these cases, surgical resection may immediately be considered and adjuvant radiotherapy should be reserved for proven recurrence cases.
Metagenomic analysis reveals rumen microbiota alteration of the yak at different stages of growth
Authors: Wang Li , Juan Li , Aboragah Ahmad , Jiang Mingfeng , Loor Juan J. 
Published: July 2021

Abstract
The Yak (Bos grunniens) is a unique ruminant species that is crucially important to agriculture in the Tibetan plateau. Variation of microorganism communities in the yak rumen is of great interest because of possible links to environmentally and economically important traits. In this study, we performed histological and microbial analyses of the yak rumen at 5 stages of growth: 1 day, 20 days, 60 days, 15 months, and 5 years of age. Tissue slices and metagenomics sequencing were used. The rumen index increased gradually from 1 day to 5 years of age. These were significant differences in rumen index between the 60d, 15m, and 5y group (p < 0.05). Compared with other time points, the thickness of muscularis along with length and width of rumen papillae at 60 d,15 m, and 5 years of age increased and differed (p < 0.05), respectively. At the phylum level, Bacteroidetes and Firmicutes were the phyla with the highest abundance in all the age groups. A total of 115,401 genes were annotated on the CAZy database. Glycoside Hydrolase (GH) had the highest relative abundance, followed by Glycosyl Transferase (GT), and Carbohydrate-binding Modules (CBM). There were significant variations for the microbial species and CAZys within the five groups. Taken together, the morphology and microbiota in the yak rumen changed at various stages of growth and likely played a significant role in the absorption of nutrients. This study provides new insights into the function of yak rumen microbiota and physiologic adaptations in plateau animals.
Introduction of Dalbergia Odorifera Enhances Nitrogen Absorption on Eucalyputs Through Stimulating Microbially Mediated Soil Nitrogen-cycling
Authors: Yao Xianyu , Zhang Qianchun , Zhou Haiju , Nong Zhi , Ye Shaoming , Deng Qi 
Published: July 2021

Abstract
Background: There is the substantial evidence that Eucalyptus for nitrogen (N) absorption and increasing the growth benefit from the introduction of N-fixing species, but the underlying mechanisms for microbially mediated soil N cycling remains unclear. Methods: We investigated the changes of soil pH, soil water content (SWC), soil organic carbon (SOC), total N (TN), inorganic N (NH4+-N and NO3--N), microbial biomass and three N-degrading enzyme activities as well as the biomass and N accumulation of Eucalyptus between a pure Eucalyptus urophylla × grandis plantation (PP) and a mixed Dalbergia odorifera and Eucalyptus plantation (MP) in Guangxi Zhuang Autonomous Region, China. Results: Compared with the PP site, soil pH, SWC, SOC and TN in both seasons were significantly higher at the MP site, which in turn enhanced microbial biomass and the activities of soil N-degrading enzymes. The stimulated microbial activity at the MP site likely accelerated soil N mineralization, providing more available N (NH4+-N in both seasons and NO3--N in the wet-hot season) for Eucalyptus absorption. Overall, the N accumulation of Eucalyptus at the MP site was increased by 19.7% and 21.9%, promoting the biomass increases of 15.1% and 19.2% in the dry-cold season and wet-hot season, respectively.Conclusion: Our results reveal the importance of microbially mediated soil N cycling in the N absorption on Eucalyputs. Introduction of D. odorifera can enhance N absorption and growth on Eucalyputs, improve soil N availability and increased soil C sequestration, which hence can be considered to be an effective sustainable management option of Eucalyptus plantations.
Evaluation of the Anterior Chamber Angle in Angle-Closure Suspect Patients by Anterior Segment Optical Coherence Tomography (AS-OCT) and Pentacam
Authors: Mahmoud Mohamed Salah El-Din , Essam Nosiba , Hammouda Layla Mohamed , Mohamed Ahmed Shawkat 
Published: July 2021

Abstract
Purpose: The study aims is to detect primary angle-closure glaucoma (PACG) suspects using both anterior segment optical coherence tomography (AS-OCT) and Scheimpflug imaging. Methods: A prospective cross-sectional observational study on forty PACG suspect patients with a range of ages from 20 to 70 years. Angle imaging by AS-OCT (Optovue Inc., Fairmont, CA) with study parameters in the superior, inferior, nasal, and temporal quadrants were anterior chamber angle (ACA), angle opening distance at 750 µm (AOD750), and trabecular-iris space area at 750 μm (TISA). Also, angle imaging using Pentacam (Oculus Optikgeräte GmbH, Wetzlar, Germany) with study parameters were the anterior chamber angle (ACA), anterior chamber depth (ACD) and, anterior chamber volume (ACV). The angle evaluation was done before and after the mydriatic test.Results: As regarding AS-OCT, after the mydriatic test, we noticed a decrease in all parameters measured, some decreased significantly while others did not. A significant decrease was noticed in ACA (TIA750) in all quadrants (P value<0.001in nasal, 0.001in superior &temporal, 0.003 in inferior) and in TISA750 in the nasal quadrant only (P-value 0.004). AOD750 and TISA750 in the remaining quadrants also decreased but not significantly as ACA. As regarding Pentacam, all parameters decreased after the mydriatic test. ACA (P-value <0.001) and ACD (P-value 0.004) showed significant statistical decrease but ACV showed statistically non-significant decrease (P-value 0.558).Conclusions: AS-OCT and Pentacam are reliable investigations for the detection of PACG suspects which needs more close follow-up for a possible increase in IOP.
Intersectionality and Diabetes in a Population of an Ambulatory Clinic, Quito-Ecuador.
Authors: Sacoto Karla Flores , Hierro Galo Sanchez Del , Hernández Felipe Moreno-Piedrahita 
Published: July 2021

Abstract
Diabetes Mellitus is a noncommunicable chronic disease, caused by the hormonal imbalance of insulin and glucose; it produces premature mortality, morbidity, and disability. A good metabolic control requires changes of personal habits and attitudes that are affected by social environment.Objective: to identify sociodemographic factors (gender, age, scholarity, civil status and insurance type) that affects metabolic control of type 2 diabetes in a specific population of an ambulatory clinic of Quito-Ecuador.Material and method: This investigation is a cross sectional study from the data taken of the first semester of the year 2018 of patients with Diabetes (ICD-10 E10-E14) from an ambulatory clinic in Quito.Results Among the data analyzed there was found association between age, gender, scholarity and insurance type with metabolic control, despite women have worse metabolic control with higher means of triglycerides, total cholesterol, LDL cholesterol, Systolic blood pressure, diastolic blood pressure and body mass index. There was a statistically significant relationship between the control of glycosylated hemoglobin (HbA1c) with age group under 65 and scholarity.Conclusion DM is a disease that affects the most vulnerable populations: lower socioeconomic status, lower level of education and greater poverty. The prognosis depends on the metabolic control that is influenced by structural and intermediate determinants of health. Traditionally, the vulnerable groups have been exposed to a greater physical and psychosocial risk that increases susceptibility to inadequate metabolic control that are related to intersectionality. Inequalities in disadvantaged population increase the risk factors for complications and premature mortality. The management of this pathology requires an integrative approach.
Verification of Maternal Transmission of Wolbachia in Field-collected Aedes Albopictus and Aedes Aegypti Using a Combination of Wolbachia and Mitochondrial DNA Sequencing
Authors: Regilme Maria Angenica F. , Inukai Tatsuya , Watanabe Kozo 
Published: July 2021

Abstract
Wolbachia is the most common bacterial endosymbiont of arthropods, such as the medically important Aedes albopictus and Aedes aegypti. Both Wolbachia and mitochondrial DNA are maternally inherited. This study collected 12 adult Aedes albopictus and 359 Aedes aegypti from 183 households in a dengue-prone area, Manila, Philippines, between June and September 2017. Aedes larvae (n = 509) were also collected from 17 water containers from 11 households. The DNA of the Aedes larvae and adults were screened for the presence of Wolbachia using the wsp and 16S markers, following optimized polymerase chain reaction (PCR) conditions, and sequenced. We also performed PCR using the mitochondrial DNA cox1 marker and sequenced the Wolbachia-positive samples. Our results showed that three out of 359 (0.84%) adult Ae. aegypti and 12 out of 12 (100%) adult Ae. albopictus were Wolbachia positive, while all of the larvae tested negative for Wolbachia (0/509; 0%). The wsp marker revealed six Wolbachia-positive Ae. albopictus, while the 16S marker showed Wolbachia in three Ae. aegypti and 10 Ae. albopictus. Three Wolbachia-positive Ae. albopictus from one household were found to have a single haplotype for all Wolbachia (wsp and 16S) and mitochondrial cox1 markers. This result indicates maternal transmission of Wolbachia in the household because siblings of a Wolbachia-infected mother mosquito share the Wolbachia and mitochondrial genomes. Our results showed the feasibility of combined sequencing analyses of Wolbachia (wsp and 16S) and mitochondrial DNA to test maternal transmission in field-collected mosquitoes.
Temporal Trends in Tolvaptan Use After Revision of National Heart Failure Guidelines in Japan
Authors: Yamazaki Yusuke , Shiraishi Yasuyuki , Kohsaka Shun , Nagatomo Yuji , Fukuda Keiichi , Kohno Takashi , Yoshikawa Tsutomu 
Published: July 2021

Abstract
Within no definite diuretic protocol for acute heart failure (AHF) patients and its variation in regional clinical guidelines, the latest national guidelines in Japan commends use of tolvaptan in diuretic-resistant patients. This study aimed to examine trends in tolvaptan usage and associated outcomes of AHF patients requiring hospitalization. Between April, 2018 and October, 2019, 1343 consecutive AHF patients (median 78 [69–85] y/o) were enrolled in a prospective, multicenter registry in Japan. Trends over time in tolvaptan usage, along with the severity of heart failure status based on the Get With The Guideline-Heart Failure [GWTG-HF] risk score, and in-hospital outcomes were investigated. During the study period, tolvaptan usage has increased from 13.0% to 28.7% over time (p for trend=0.07), and 49.4% started tolvaptan within 3 days after admission. The GWTG-HF risk score in the tolvaptan group has significantly decreased over time, while that in the non-tolvaptan group has unchanged. There were no differences in the in-hospital mortality rate between the patients with and without tolvaptan (6.7% vs. 5.8%). After revision of the Japanese clinical practice guidelines for AHF in March 2018, tolvaptan usage for AHF patients has steadily increased. However, in-hospital outcomes including mortality do not seem to be affected.
The Dynamics of Cooperation in Society. The ECHO-EGN Model
Authors: Madeo Dario , Salvatore Sergio , Mannarini Terri , Mocenni Chiara 
Published: July 2021

Abstract
Understanding the dynamics of cooperative behavior of individuals in complex societies represents a fundamental research question which puzzles scientists working in heterogeneous fields. Many studies have been developed using the unitary agent assumption, which embeds the idea that when making decisions, individuals share the same socio-cultural parameters. In this paper, we propose the ECHO-EGN model, based on Evolutionary Game Theory, which relaxes this strong assumption by considering the heterogeneity of three fundamental socio-cultural aspects ruling the behavior of groups of people: the propensity to be more cooperative with members of the same group (Endogamy), the propensity to cooperate with the public domain (Civicness) and the propensity to prefer connections with members of the same group (Homophily). The ECHO-EGN model is shown to have high performance in describing real world behavior of interacting individuals living in complex environments. Extensive numerical experiments allowing the comparison of real data and model simulations confirmed that the introduction of the above mechanisms enhances the realism in the modelling of cooperation dynamics. Additionally, theoretical findings allow us to conclude that Endogamy may limit significantly the emergence of cooperation.