bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant-derived molecules in monkeypox management: insight and alternative therapeutic strategies
Authors: Ndayambaje Martin , Munyeshyaka Emmanuel , Dieumerci Olive , Habyarimana Thierry , Ndishimye Pacifique , Naya Abdallah , Oudghiri Mounia 
Published: February 2025

Abstract
The WHO and CDC recently declared monkeypox virus (MPXV) a zoonotic disease known as monkeypox (Mpox) a Public Health Emergency of International Concern. According to the CDC, no treatment is specifically approved for Mpox infections. Medicinal plants are crucial in healthcare and economic development, particularly for low- and middle-income countries. This review offers valuable insights into the pathogenesis and the management of Mpox through therapeutic approaches and vaccination strategies using plant-based molecules. Core structural proteins necessary for both viral entry and the immune response, including A29, H3L, and L1R, are involved in the pathogenesis of MPXV. Potential targets for vaccines include proteins like A35R and B6R, which are essential to the propagation of viruses. The MPXV evades the immune system by concealing its DNA, suppressing the interferon response, limiting T and NK cell activation, and preventing apoptosis, complicating vaccine and treatment development. Antivirals (tecovirimat, brincidofovir) and vaccinations (JYNNEOS, ACAM2000) manage Mpox. A recent study revealed early clinical trial results, indicating that the antiviral drug tecovirimat, a well-known conventional treatment, is no more effective than a placebo against the clade I virus type Research gaps, low vaccination effectiveness, and availability are challenges. This review offers a novel perspective on combating the global threat of Mpox by investigating alternative management strategies centered on plant-derived compounds.

Graphical Abstract
Interprofessional collaboration in acute care settings: qualitative research among nurses and radiographers
Authors: Bonacaro Antonio , Risoli Camilla , Bof Federica , Carcaterra Yasmine , Cuzzi Claudia , Danieli Chiara , Guasconi Massimo , Artioli Giovanna 
Published: February 2025

Background: Interprofessional collaboration (IPC) not only benefits the multiprofessional team, but also has the potential to improve patient outcomes. Understanding the roles of health professional colleagues can lay a strong foundation for IPC, particularly in settings where timely procedures are crucial. Aims. This study aimed to analyse perceptions of IPC among nurses and radiographers working in acute care settings. Methods: A descriptive qualitative study involving online focus groups of nurses and radiographers working in acute care. The data collected were analysed through thematic analysis. Findings: Four dimensions emerged from the analysis – organisational dimension, cognitive dimension, individual dimension and relational. Each represented a well-defined area and could be divided further into subthemes. Conclusion: The four dimensions influence IPC among nurses and radiographers in acute care. Improving the factors identified and implementing changes can have a positive impact on patients' quality of care.
A modified systematic review of the impact of cultural beliefs on the acceptability and accessibility of adult palliative care in Tanzania
Authors: Breese Amelia , Clark Maria , Halliday Lesley 
Published: February 2025

Background: Palliative care (PC) is recognised by the United Nations as a crucial element of universal health coverage. This article explores the cultural beliefs around the acceptability and accessibility of PC in Tanzania, East Africa. Aim: To provide insight into barriers for the provision of culturally safe PC in this region. Method: Qualitative studies researching adult perspectives on PC in Tanzania between 2010 and 2022 were critically appraised. Findings: Of 153 studies identified in the initial search, seven met the inclusion criteria. Four key themes were identified: acceptability of PC for recipients; acceptability of PC for providers; accessibility of PC for recipients and accessibility of PC for providers. Conclusion: Cultural beliefs around the acceptability of PC included shared values for individuals at the end of life and challenges around breaking bad news. Barriers to the accessibility of PC included training opportunities and opioid availability. Further research prioritising ‘cultural safety’ is necessary to improve PC provision in Tanzania.
Assessment of nurses' approaches to palliative and end-of-life care in the intensive care and high-dependency unit
Authors: Tzenalis Anastasios , Maria Vasdeki , Kipourgos George , Gkotsi Angelikh , Eleni Albani 
Published: February 2025

Background: Palliative care provision is a serious challenge for nursing staff as it involves end-of-life care decisions, as well as a very close relationship with the grief and pain of the patient and their relatives. Their beliefs and attitudes regarding palliative care affect the quality of care, and can potentially influence whether a nurse experiences burnout in their career. Aims: To investigate the attitudes and beliefs of nursing staff about palliative care and correlation with various demographic factors. Methods: The study used a cross-sectional design and included nurses and nursing assistants who worked at Intensive Care Units and High Dependency Units. The authors assessed the attitudes on palliative care using the Frommelt Attitudes Toward Care of the Dying Scale (FATCOD) scale. Findings: A total of 150 nurses/nursing assistants. Their satisfaction with care and the months since the patient's initial diagnosis were positively associated with a more positive quality of life. Participants' beliefs about end-of-life care are positively and sometimes negatively influenced by demographic factors, such as their gender and previous work experience. Conclusion: The findings of the study may prove valuable in understanding the challenges faced by nurses caring for patients in the final stretch of the patient's life and may be the starting basis for initiating educational programmes on palliative care.
Potential blood biomarkers that can be used as prognosticators of spontaneous intracerebral hemorrhage: A systematic review and meta-analysis
Authors: Sasongko Aloysius Bagus , Perdana Wahjoepramono Petra Octavian , Halim Danny , Aviani Jenifer Kiem , Adam Achmad , Tsai Yeo Tseng , Wahjoepramono Eka Julianta , July Julius , Achmad Tri Hanggono 
Published: February 2025

Background
Predicting nontraumatic spontaneous intracerebral hemorrhage (SICH) patient prognosis has been commonly practiced, particularly when providing informed consent and considering surgical treatment. Biomarkers might provide more real-time evaluation of SICH patients’ condition than clinical prognostic scoring systems. This study aimed to evaluate the reliability of blood biomarkers in predicting prognosis in SICH patients by systematic review and meta-analysis.

Methods
Studies that evaluated the association of blood biomarker(s) with mortality and/or functional outcome in SICH patients up to October 11, 2024, were identified through PubMed, Google Scholars, Scopus databases, and reference lists. Studies that satisfied the inclusion criteria were included in the meta-analyses. Good functional outcome was defined by patient’s Glasgow Outcome Scale (GOS) ≥ 4 or modified Rankin scale mRS ≤ 2. Blood biomarkers were classified into the following categories: angiogenic factors, growth factors, inflammatory biomarkers, coagulation parameters, blood counts, and others. Individual meta-analysis was performed for every evaluation endpoint:7 days, 30 days, 3 months, 6 months, and 1 year. Meta-analyses were performed using Random Effect Mean-Difference with a 95% Confidence Interval for continuous data and visualized as forest plots in RevMan version 5.3 software. Cochrane Tool to Assess Risk of Bias in Cohort Studies was used to assess potential risk of bias of the included studies. GRADE Profiler was used to assess quality of evidence.

Results
Seventy-seven studies fulfilled the inclusion criteria. Surviving SICH patients have significantly lower C-reactive protein (CRP), D-dimer, copeptin, S100β, white blood cell (WBC), monocyte, and glucose than non-surviving patients. SICH patients with good functional outcome have lower D-dimer, Interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), WBC count, neutrophil count, monocyte count, copeptin and significantly higher lymphocyte counts and calcium levels. Out of all blood biomarkers that were evaluated, only S100β and copeptin had very high effect size and high certainty of evidence.

Conclusion
It is interesting to notice that many blood biomarkers significantly associated with SICH patients’ outcomes are related to inflammatory responses. This suggests that modulation of inflammation might be essential to improve SICH patients’ prognosis. We confidently concluded that S100β and copeptin are the most reliable blood biomarkers that can be used as prognosticators in SICH patients. On other biomarkers, in addition to heterogeneities and inconsistencies, several factors might affect the conclusions of current meta-analysis; thus, future studies to increase the certainties of evidence and effect size on other biomarkers are crucial.
SARS-CoV-2 infection is associated with higher chance of diabetes remission among Veterans with incident diabetes
Authors: Wander Pandora L. , Lowy Elliott , Korpak Anna , Beste Lauren A. , Kahn Steven E. , Boyko Edward J. 
Published: February 2025

Objective
To examine the impact of SARS-CoV-2 on long-term glycemia.

Research design and methods
We conducted a retrospective inception cohort study using Veterans Health Administration data (March 1, 2020–May 31, 2022) among individuals with ≥ 1 positive nasal swab for SARS-CoV-2 and individuals with ≥ 1 laboratory test of any type but no positive swab. Two incident diabetes cohorts were defined based on: 1) a computable phenotype using a combination of diagnosis codes, laboratory tests, and receipt of glucose-lowering medications (n = 17,754); and 2) the presence of ≥ 2 HbA1c results ≥ 6.5% (n = 4,768). We fit log-binomial models examining associations of SARS-CoV-2 with diabetes remission, defined as ≥ 2 HbA1c measurements < 6.5% ≥ 90 days apart after cessation of any glucose-lowering medications. To help equalize laboratory surveillance of glycemia, we conducted a subgroup analysis among non-hospitalized participants.

Results
In cohorts 1 and 2 respectively, 25% and 29% had ≥ 1 positive test for SARS-CoV-2 prior to enrollment, and 21% and 11% had remission. SARS-CoV-2 was associated with a higher chance of remission by both definitions (1: RR 1.22 [95%CI 1.14–1.29]; 2: RR 1.27 [95%CI 1.07–1.50]) over an average 503 (±202) and 494 (±184) days. The association was attenuated among non-hospitalized participants (1: RR 1.11 [1.04–1.20]; 2: R: 1.17 [95%CI 0.97–1.42]).

Conclusions
Diabetes remission was more common in Veterans with new-onset diabetes after SARS-CoV-2. In non-hospitalized participants, who were likely to have more similar laboratory surveillance, the association was diminished. Differences in surveillance or transient hyperglycemia may explain the observed association.
Muškēnum in Third-Millennium BC Mesopotamia
Authors: Bartash Vitali , Pottorf Andrew 
Published: February 2025

Abstract
This article reexamines the origins and social status of the muškēnū (
maš.gag.en
, etc., “those who prostrate themselves”) in ancient Mesopotamia. Previously thought of as commoners, analysis of third-millennium sources reveals them to be settled outsiders, distinct from citizens of the communities they inhabited. This precarious position necessitated protection from rulers or other powerful figures. Evidence suggests the Semitic Middle Euphrates-Tigris region as the homeland of this phenomenon. Early Dynastic data (ca. 2600–2300 BC) portray the muškēnū as low-status outsiders by placing them in the context of male regular and house-born slaves, menial workers, robbers/seminomads, and female sex workers. Akkadian conquerors brought the phenomenon to Sumer during the twenty-third century BC. The muškēnū lived in imperial centers and traveled between Sumerian cities. The data on the muškēnū become more common during the Ur III period (2110–2003 BC). They lived primarily in royal settlements and on the kingdom’s periphery, suggesting a deliberate policy to establish a loyal social base, and they were “people” rather than “natives” of these towns. Male muškēnū were typically conscripted full time in low-income occupations involved in animal husbandry and cultivation, and they seldom held administrative positions. Male citizens, on the other hand, enjoyed a better economic position with part-time work and additional income opportunities. Few muškēnū women (feminine forms of the term are not attested) might have been forced into penal labor like some citizen women. Sex work was another profession for some muškēnū women, also mirroring the situation for some citizen women. During the Old Babylonian period (2002–1595 BC), muškēnum remained a term for a group of state-protected free individuals distinct from regular citizens of southern Babylonia. What was new is that Babylonian states used this category as a blueprint to conceptualize the entire free population as royal/state subjects, a concept originally alien in the south.
Variation in mammal ecological patterns in response to seasonality in a Brazilian tropical dry forest
Authors: Falcão Maria Luísa , Marinho Paulo Henrique , Venticinque Eduardo Martins 
Published: February 2025

Abstract
The scientific question addressed in this study is how mammals in the Caatinga dry forest of northeast Brazil adapt to seasonal variations, specifically regarding their activity and occupancy patterns and species richness and composition. To investigate, we deployed camera traps across Furna Feia National Park during both wet and dry seasons in 2018. We utilized methods such as rarefaction curves, circular statistics, and occupancy models to analyze data collected from 44 and 40 sampling points during the wet and dry seasons, respectively. We obtained 485 records of 11 mammal species from six orders and nine families, including endangered species like Leopardus tigrinus and Herpailurus yagouaroundi. Notably, we captured the first photographic evidence of a free-living Dicotyles tajacu in Rio Grande do Norte state. Results indicate that some mammals adjust their activity to avoid peak heat, particularly during the dry season, with no significant change in species richness but with important changes in occupancy and relative abundance between seasons. Our research expects to shed light on mammalian ecology in seasonally dry environments, contributing to species management and conservation efforts.
Flux-growth synthesis and structural characterization of R
6Nb4Al43 (R = Sm, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu)
Authors: Patha Shrenik , Bhatt Soham , Tortorella Daniel S. , Donnelly Connor , Bobev Svilen 
Published: February 2025

Abstract
Presented are the flux-growth synthesis and the structural characterization of the series of ternary aluminides R
6Nb4Al43, with R representing the rare-earth elements Sm, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu. Although not new compounds, the structures of R
6Nb4Al43 have not been unequivocally established to date. This study showcases comprehensive structural work that has been carried out using single-crystal X-ray diffraction methods. The nine title compounds are shown to be isotypic and to crystallize in a hexagonal crystal system with space group P63/mcm (no. 193). The crystal structure is rather complex and the structure type adopted is known as Ho6Mo4Al43 (Pearson symbol hP106). Structural refinements from single-crystal X-ray diffraction data in all cases help establish the long range crystallographic ordering and no homogeneity width in any of the R
6Nb4Al43 crystals. There is a monotonic decrease in lattice parameters and unit cell volume with increasing the R-element atomic number, corresponding to the lanthanide contraction and the atomic size reduction across the 4f-series. Anomalous behavior in Yb6Nb4Al43 is observed though, whereby a divergence from this trend in decreasing in the unit cell volume is detected. Although not corroborated by magnetic measurements, we posit that the larger than expected the unit cell volume in Yb6Nb4Al43 is likely due to Yb2+/Yb3+ mixed-valent state, where the closed-shell 4f14 electronic configuration for Yb2+ affects the structural parameters, causing the deviation from the rest of the structures with R
3+ ions.
A Needs Analysis and Recommendations for Physical Assessments and Training Adaptations for Judo Athletes With Visual Impairments: A Brief Review
Authors: Kons Rafael Lima , Weldon Anthony , Bishop Chris , Cloak Ross , Detanico Daniele 
Published: February 2025

ABSTRACT
This article reviews the unique needs, performance aspects, and assessment recommendations for judo athletes with visual impairments. A needs analysis reveals the importance of custom training strategies and environmental adaptations to facilitate training and competition. Performance aspects, including time-motion analysis and match-related performance, are discussed to elucidate the specific demands and movement patterns in judo athletes with visual impairment. In addition, recommendations are proposed to develop standardized protocols for physical assessment and skill evaluation, ensuring the optimization of training strategies. Collaborative research initiatives are recommended to further explore integrating multisensory stimuli and enhance athletic development in this population. By addressing the unique challenges judo athletes with visual impairment face and providing evidence-based recommendations for performance assessment and training optimization, this review contributes to advancing adapted sports science and promoting inclusivity and excellence in judo.
Зміна спектральних характеристик рідкокристаліцічного активного середовища допованого багатошаровими вуглецевими нанотрубками під дією нітроген діоксиду
Authors: Когут І. , Микитюк З. , Качурак Ю. , Вісьтак М. , Блавт О. , Кремер І. , Шимчишин О. , Тимкович Р. 
Published: February 2025

В роботі досліджено вплив діоксиду азоту (NO2) на спектральні характеристики рідкокристалінчної суміші, легованої багатошаровими нанотрубками. Рідкокристалічну суміш синтезовано на базі холестеричного рідкого кристалу BLO-61 та нематика 5CB (26%) із широким діапазоном температур існування мезофази, концентрація нанотрубок становила до 0,7%. Встановлено, що введення нанотрубок в суміш призводить до істотного збільшення чутливості суміші до неорганічних речовин за рахунок збільшення абсорбції. Проведено аналіз зміни спектральних властивостей суміші при різних концентраціях діоксиду азоту в об'ємі сенсора та визначено коефіцієнт спектральної чутливості. Отримані результати вказують на можливе використання цієї суміші як чутливого елемента сенсора для виявлення азотних сполук у майбутньому.
Efectos de la aplicación de un programa de mindfulness sobre la ansiedad y la atención en alumnado adolescente
Authors: Molina del Peral José Antonio 
Published: February 2025

El interés por los programas de mindfulness está en continuo aumento, debido a los resultados positivos que ha recogido la investigación empírica tras años de estudios diversos. Uno de los campos en los que se podrían lograr grandes beneficios es en el de la educación, ya que el mindfulness favorece muchos de los procesos mentales necesarios dentro del proceso de enseñanza-aprendizaje. Los objetivos del presente estudio fueron comparar los niveles ansiedad, en sus versiones rasgo y estado, y de atención focalizada tras la realización de un programa de mindfulness de 8 sesiones. La muestra estuvo compuesta por 138 participantes de 1º y 2º de Educación Secundaria Obligatoria, con edades comprendidas entre 12 y 14 años, a los que se les aplicó el Cuestionario de Ansiedad Estado-Rasgo, versión para adolescentes (Spielberger, Gorsuch y Lushene, 1982) y el Test de Percepción de Diferencias Revisado (Thurstone y Yela, 2012) como medida pretest y postest. Tras la aplicación del programa de mindfulness se encontraron diferencias significativas en ambas variables, en sentido positivo para la variable atención y en sentido negativo para la ansiedad estado y rasgo. Se analizan los posibles factores explicativos de la elevación de la ansiedad tras la realización del programa de mindfulness y los efectos positivos en la atención tras la realización de dicho programa, atendiendo a factores clave como la aplicación del programa por parte de una persona inexperta, o el momento temporal en que se realizó la aplicación del programa y la medida del postest, cercana a los exámenes.
Ambiente sano: aproximaciones a la garantía de derechos en Colombia
Authors: García-Otero Ruth cristina , Hossain Luisa , Vasquez Isabella 
Published: February 2025

Objetivo: revisar el impacto jurídico del derecho al entorno saludable armonizado con los demás derechos básicos, mediante el análisis de la evolución constitucional bajo la premisa de que la Constitución Política de Colombia de 1991 aporta cambios significativos y que la jurisprudencia reafirma su importancia, para el desarrollo social. Método: esta investigación se desarrolla a través de un enfoque sistemático y socio jurídico realizado a través del examen teórico – deductivo de jurisprudencia, doctrina y referentes internacionales. Resultados: se evidencia la relación entre este derecho y otros, al igual que su doble titularidad de derecho- deber por lo que su garantía reposa en cabeza de todos los ciudadanos del mundo, no solo de los Estados. Conclusiones: el derecho al medio ambiente sano tiene un impacto significativo en el desarrollo del ser humano y por tanto una afectación directa a otros derechos fundamentales y la importancia de la acción del individuo en su fomento y protección. Por otra parte, se puede interpretar que la legislación colombiana trabaja en función del control y no de la prevención, aspecto que se agudiza en el desarrollo de hostilidades.
Patient characteristics, therapy service delivery and patient outcomes following pyrocarbon proximal interphalangeal joint arthroplasty
Authors: Hendricks Nureesh , Nadasan Thayananthee , Olagbegi Oladapo Michael , Chemane Nomzamo 
Published: February 2025

Background/Aim: Studies on likely sociodemographic and pre-surgical determinants of hand function and satisfaction following pyrocarbon proximal interphalangeal joint arthroplasty (PPIJA) are scarce. The primary aim of this study was to explore the association between pre-surgical sociodemographic and clinical characteristics and post-surgical hand function and satisfaction of patients who underwent PPIJA. A secondary aim was to evaluate the effects of the procedure on pain and active range of movement (AROM) using retrospective data and on-site follow-up assessmentMethods: A panel survey of 48 patients (male = 13; female = 35) with median age of 64 years, who had PPIJA between 2001 and2012, with a total of 61 arthroplasties, was conducted. During follow-up, participants' pain and satisfaction, AROM, and hand disability were assessed using the Pain and Satisfaction Questionnaire (PSQ), goniometer, and the Disability of the Shoulder, Hand Shoulder (DASH) Questionnaire respectively.Results: The main reason for surgery amongst participants was joint stiffness (68%) while 33.3% of the participants had a repeat surgery. Participants' median satisfaction and DASH scores at final assessment were 3 and 22.55 respectively. Patients who underwent arthroplasty once had significantly higher median PSQ scores (p = 0.011) than those who had their surgery rrepeated. Pain significantly reduced (p < 0.001) while AROM significantly increased (p = 0.001) from pre-operative assessment to final follow-up assessment.Conclusions: Pyrocarbon arthroplasty improved treatment outcomes regarding pain and joint motion; post-operative satisfaction may be associated with patients having a repeat surgery.
Keywords: Pyrolytic carbon, proximal interphalangeal joint replacement, arthritis, treatment outcome