bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is simulation-based team training performed by personnel in accordance with the INACSL Standards of Best Practice: SimulationSM?—a qualitative interview study
Authors: Finstad Anne Strand , Ballangrud Randi , Aase Ingunn , Wisborg Torben , Romundstad Luis Georg , Bjørshol Conrad Arnfinn 
Published: September 2021

Abstract
Background
Anesthesia personnel was among the first to implement simulation and team training including non-technical skills (NTS) in the field of healthcare. Within anesthesia practice, NTS are critically important in preventing harmful undesirable events. To our best knowledge, there has been little documentation of the extent to which anesthesia personnel uses recommended frameworks like the Standards of Best Practice: SimulationSM to guide simulation and thereby optimize learning. The aim of our study was to explore how anesthesia personnel in Norway conduct simulation-based team training (SBTT) with respect to outcomes and objectives, facilitation, debriefing, and participant evaluation.

Methods
Individual qualitative interviews with healthcare professionals, with experience and responsible for SBTT in anesthesia, from 51 Norwegian public hospitals were conducted from August 2016 to October 2017. A qualitative deductive content analysis was performed.

Results
The use of objectives and educated facilitators was common. All participants participated in debriefings, and almost all conducted evaluations, mainly formative. Preparedness, structure, and time available were pointed out as issues affecting SBTT.

Conclusions
Anesthesia personnel’s SBTT in this study met the International Nursing Association for Clinical Simulation and Learning (INACSL) Standard of Best Practice: SimulationSM framework to a certain extent with regard to objectives, facilitators’ education and skills, debriefing, and participant evaluation.
Salazosulfapyridine-induced agranulocytosis in a patient on chronic hemodialysis with seronegative spondyloarthropathy: a case report
Authors: Iida Takeshi , Nakata Kimihiko , Fukui Masayoshi , Umeda Masaru 
Published: September 2021

AbstractBackgroundSalazosulfapyridine is a generally safe drug often used to treat rheumatoid arthritis and ulcerative colitis. However, agranulocytosis is a rare but serious adverse effect of this drug. To date, there have been no reports describing the clinical course of salazosulfapyridine-induced agranulocytosis in a chronic hemodialysis patient.Case presentationThe patient was a 64-year-old man with IgA nephropathy who had been on chronic hemodialysis for about 3 years. For 1 month, he had general fatigue, mild fever, and pain in multiple joints of the upper extremities. He was hospitalized and underwent detailed examinations in our department. Laboratory investigations revealed an erythrocyte sedimentation rate of 67 mm/h and a C-reactive protein level of 7.73 mg/dL. Rheumatoid factor and anti-cyclic citrullinated peptide antibody were negative. Musculoskeletal ultrasonography showed inflammation of the tendon sheath in both wrists and the right shoulder joint. Computed tomography scans revealed osteosclerosis and narrowing of the sacroiliac joint. The diagnosis was seronegative spondyloarthropathy. He was started on salazosulfapyridine. Four weeks later, he had a high fever and low granulocyte count. Treatment with granulocyte colony-stimulating factor was started. The agranulocytosis could not be ascribed to any other cause and was considered an adverse effect of salazosulfapyridine, which was then stopped. Nine days later, the granulocyte count had recovered and the fever had resolved.ConclusionsCurrently, there are no guidelines on the use of salazosulfapyridine in chronic hemodialysis patients. The starting dosage should be smaller for these patients than for patients without renal impairment. Also, the laboratory monitoring interval for complete blood count should be shorter than usual.
Prevalence of carbapenemase-producing Klebsiella pneumoniae at a tertiary care hospital in Kathmandu, Nepal
Authors: Pyakurel Susil , Ansari Mehraj , Kattel Smriti , Rai Ganesh , Shrestha Prasha , Rai Kul Raj , Sah Anil Kumar , Rai Shiba Kumar 
Published: September 2021

Abstract
Aim
Although carbapenem is the last-resort drug for treating drug-resistant Gram-negative bacterial infections, prevalence of carbapenem-resistant bacteria has substantially increased worldwide owing to irrational use of antibiotics particularly in developing countries like Nepal. Therefore, this study was aimed to determine the prevalence of carbapenemase-producing K. pneumoniae and to detect the carbapenemase genes (blaNDM-2 and blaOXA-48) in at a tertiary care hospital in Nepal.

Materials and methods
A hospital-based cross-sectional study was carried out from June 2018 to January 2019 at the Microbiology Laboratory of Annapurna Neurological Institute and Allied Sciences, Kathmandu, Nepal. Different clinical samples were collected and cultured in appropriate growth media. Biochemical tests were performed for the identification of K. pneumoniae. Antibiotic susceptibility testing (AST) was performed by the Kirby–Bauer disc diffusion method. The modified Hodge test (MHT) was performed to detect carbapenemase producers. The plasmid was extracted by the modified alkaline hydrolysis method. Carbapenemase-producing K. pneumoniae were further confirmed by detecting blaNDM-2 and blaOXA-48 genes by PCR using specific forward and reverse primers followed by gel electrophoresis.

Results
Out of the total 720 samples, 38.9% (280/720) were culture positive. K. pneumoniae was the most predominant isolate 31.4% (88/280). Of 88 K. pneumoniae isolates, 56.8% (50/88) were multi-drug resistant (MDR), and 51.1% (45/88) were MHT positive. Colistin showed the highest sensitivity (100%; 88/88), followed by tigecycline (86.4%; 76/88). blaNDM-2 and blaOXA-48 genes were detected in 24.4% (11/45) and 15.5% (7/45) of carbapenemase-producing K. pneumoniae isolates, respectively.

Conclusion
The rate of MDR and carbapenemase production was high in the K. pneumoniae isolates. Colistin and tigecycline could be the drug of choice for the empirical treatments of MDR and carbapenemase-producing K. pneumoniae. Our study provides a better understanding of antibiotic resistance threat and enables physicians to select the most appropriate antibiotics.
Carica papaya and Mangifera indica modulate haematological, biochemical and histological alterations in atrazine-intoxicated fish, Clarias gariepinus (Burchell 1822)
Authors: Owolabi Olufemi D. , Abdulkareem Saratu I. 
Published: September 2021

Abstract
Background
Atrazine has impacted negatively on fish by inducing significant alterations in their haematological, biochemical and histological parameters. Mitigating such alterations to enhance fish survival becomes pertinent. Unfortunately, readily available and eco-friendly remedies are scarce. The study, therefore, investigated the potential ameliorative effects of dietary supplementation of aqueous Carica papaya and Mangifera indica leaf extracts on atrazine-induced toxicity and oxidative damage in the tissues of Clarias gariepinus. Fish (average weight: 10.57 ± 1.69 g, and average length: 10. 36 ± 1.26 cm) were randomly divided into six groups of ten samples each. Group I served as control and administered borehole water only, group II was exposed to 8.50 µg/l atrazine corresponding to ¼ of 96 h LC50, group III was treated with low (0.25 mg/g) concentration of each extract alone, group IV was exposed to 8.50 µg/l atrazine and treated with the low concentration of each extract, group V was administered with high (0.75 mg/g) concentration of each extract alone, and group VI was exposed to 8.50 µg/l atrazine and treated with the high concentration of each extract. The experiment spanned 28 days after which the haematological, biochemical and histopathological alterations were assayed.

Results
Atrazine intoxication significantly induced oxidative damage in the gill and liver, culminating into different histopathological disorders, decreased haematological parameters, increased serum, gill and liver levels of malondialdehyde and enzyme biomarkers (alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase and acetylcholinesterase). On the other hand, atrazine exposure caused decreased levels of glucose, protein and superoxide dismutase in the tissues. Treatment with diets fortified with both extracts significantly increased all the decreased haematological parameters, reduced the serum levels of the elevated malondialdehyde and tissues enzyme biomarkers in a concentration-dependent manner. Biochemical parameters in the tissues were also improved with dietary supplementation of the extracts. Histopathological examination of both tissues showed ameliorating effects of both extracts in restoring the structural and functional integrity of each tissue.

Conclusions
These results suggest that the extracts have ameliorative potentials against atrazine-induced peroxidative injury in C. gariepinus. The utilisation of these extracts could enhance better health management practices, particularly in a rice-cum fish culture, where atrazine application is common.
Bacillus-based nano-bioformulations for phytopathogens and insect–pest management
Authors: Kumar Pradeep , Pandhi Shikha , Mahato Dipendra Kumar , Kamle Madhu , Mishra Archana 
Published: September 2021

Abstract
Background
Recent concerns linked with the application of chemical pesticides and the increasing necessity of low inputs sustainable agriculture have put the use of microbial biocontrol agents and bio-pesticides to the forefront for their application against plant pathogens and insect–pest management.

Results
This review tended to scrutinize the prospects of microbial biocontrol agents and microbes-based nano-formulations against plant diseases and for pest management with emphasis on bacteria-based nanoparticles, especially derived from Bacillus species. It also tended to discuss the probable mechanism of action and effect on plant growth along with its prospects in a brief manner.

Conclusion
The use of microbial biocontrol agents offers effective, eco-friendly, and long-lasting management of plant diseases. The employment of nanotechnology in the field of biopesticides has emerged as a promising solution. Nano-biopesticides in the form of biologically derived active pesticides or compounds integrated as nanoparticles and integrated into a suitable polymer have application in insect–pest management.
Sinus venous thrombosis as a complication of COVID-19-associated hypercoagulability
Authors: Zarrouk Sinda , Finsterer Josef 
Published: September 2021

AbstractSinus venous thrombosis (SVT) is an increasingly recognised complication of not only SARS-CoV-2 infections, but also of SARS-CoV-2 vaccinations. SVT is attributed to hypercoagulability, a common complication of COVID-19, disregarding the severity of the infection. Hypercoagulability in COVID-19 is explained by direct activation of platelets, enhancing coagulation, by direct infection and indirect activation of endothelial cells by SARS-CoV-2, shifting endothelial cells from an anti-thrombotic to a pro-thrombotic state, by direct activation of complement pathways, promoting thrombin generation, or by immune thrombocytopenia, which also generates a thrombogenic state. Since SVT may occur even in anticoagulated COVID-19 patients and may have an unfavourable outcome, all efforts must be made to prevent this complication or to treat it accurately.
Transcranial approaches for pituitary adenomas: current indications and clinical and radiological outcomes
Authors: Salama Mohamed M. , Rady Mohamed Reda 
Published: September 2021

Abstract
Background
The indications of transcranial approaches for pituitary adenomas have declined in the last decades with the widespread performance of endoscopic transsphenoidal approaches.
The aim of the study was to review the current indications of transcranial approaches for pituitary adenomas and to evaluate the clinical and radiological outcome following these approaches.

Patients and methods
This study included 16 patients with fresh, residual, or recurrent pituitary adenomas operated upon by transcranial approaches alone or in combination with transsphenoidal approaches. The indication to perform a transcranial approach was reviewed for each patient. Postoperative clinical outcome and the extent of tumor resection were assessed.

Results
The indications of transcranial approaches were significant parasellar and/or anterior fossa extensions in 6 patients, failed previous transsphenoidal surgery in 3 patients, giant adenoma extending into the third ventricle in 3 patients, dumbbell-shaped adenoma in 2 patients, and doubtful diagnosis in 2 patients. Two patients with invasive giant adenomas were operated upon by a combined approach. There was a single mortality. Permanent complications included visual loss in one patient, third nerve palsy in one patient, hypopituitarism in two patients, and permanent diabetes insipidus in two patients. Gross total resection was achieved in one patient, subtotal resection in seven patients, and partial resection in eight patients.

Conclusion
Transcranial approaches are still needed for some complex pituitary adenomas particularly giant tumors with significant lateral, anterior, or superior extensions, tumors with fibrous consistency particularly after failure of transsphenoidal approach, and dumbbell-shaped tumors with severe constriction at the diaphragm.
Ionic liquid-plasticised composites of chitosan and hybrid 1D and 2D nanofillers
Authors: Chen Pei , Xie Fengwei , Tang Fengzai , McNally Tony 
Published: September 2021

AbstractThe focus of this research was to study the effect of combining nanofillers with different geometry and surface chemistry on the structure and properties of biopolymers as an alternative to traditional plastics. How the inclusion of 2D graphene oxide (GO) or reduced GO (rGO) combined with 1D sepiolite (SPT) or cellulose nanocrystals (CNCs) affect the structure and properties of chitosan and chitosan/carboxymethyl cellulose (CMC) materials was investigated. A 3D interconnected microstructure formed, composed of GO and SPT due to the strong interactions between these hydrophilic nanofillers. The chitosan/CMC/GO/SPT composite had the highest tensile strength (77.5 ± 1.2 MPa) and Young’s modulus (1925.9 ± 120.7 MPa). For the un-plasticised matrices, hydrophobic rGO nanosheets generally hindered the interaction of SPT or CNCs with the polysaccharides (chitosan and CMC) and consequently, composite properties were mainly determined by the rGO. However, for the chitosan matrix plasticised by 1-ethyl-3-methylimidazolium acetate ([C2mim][OAc]), rGO + CNCs or rGO + SPT disrupted polymer chain interactions more effectively than the nanofillers when added alone and resulted in the chitosan being more plasticised, as shown by increased chain mobility, ductility, and surface hydrophilicity. For the [C2mim][OAc]-plasticised chitosan/CMC matrix, the advantages of including hybrid fillers, rGO + CNCs or rGO + SPT, were also obtained, resulting in higher thermal stability and surface hydrophobicity.
Graphical Abstract
Are you a team player or a personal pinner? situating pinterest as part of teachers’ online and offline professional learning networks
Authors: Lundgren Lisa , Curcio Rachelle , Schroeder Stephanie E. 
Published: September 2021

AbstractPinterest, a popular social networking site, is used as a resource by educators across all grade levels. We take the perspective that Pinterest acts as a professional learning network (PLN) and interrogate the ways that teachers share resources within online/offline PLNs. Eighty-eight teachers responded to a survey that asked about their social media use as well as their sharing of Pinterest resources with their professional colleagues. Building from the media use typology, we developed the Peer-to-Peer Pinterest Sharing Typology to describe types of sharing, finding that most respondents indicated that they did not share resources, others shared if forced to, and some shared as a way to enhance collegial collaboration. This research expands limited empirical work on both Pinterest as a PLN and on how learning and resources from online PLNs cross into school-based ones. This work will be of interest to those who seek to understand how social media sites play a role in teacher professional learning.
A retrospective comparison of two different immobilization systems for radiotherapy of extremity soft tissue sarcomas and its influence on CTV-PTV margin
Authors: Mohamed Reham , Shuja Muhammad , Al-Hazienh Asaad , Aly Moamen 
Published: September 2021

Abstract
Background
On account of extremity wide range of movements and difficulty of reproducibility during irradiation of extremity sarcomas, assorted immobilization strategies are employed to eliminate setup errors. The study purpose was to compare the setup errors of the commonly used immobilization tools and to define planning target volume (PTV) margins for each device.

Methods
A retrospective review comparing Vac-Loc™ and thermoplastic cast (Tcast) was conducted. On radiotherapy treatment, portal imaging was matched with the pre-treatment simulation imaging for both fixation tools. The isocenter shifts and total vector error (TVE) were compared. Random (σ) and systemic errors (Σ) were computed and PTV margins were defined.

Results
Three hundred seven shifts in each direction measured in 14 patients. Mean displacements for the Vac-Loc™ and Tcast, respectively, were as follow: vertical; -0.01 cm vs. 0.02 cm, longitudinal; 0.03 cm vs. 0.04; lateral; 0.04 cm vs. 0.00 cm and TVE; 0.15 cm vs. 0.17 cm with no significant statistical difference. Random and systemic errors were comparable for both devices. The lateral displacement and rotational random errors were higher Vac-Loc™ compared to Tcast. Overall measured PTV margins were marginally lower for Tcast compared to Vac-Loc™.

Conclusion
Vac-Loc™ and Tcast are valid options for immobilization with no clear superiority of either device. The marginal advantage of Tcast warrants further prospective studies.
A mixed-methods study of multi-level factors influencing mammography overuse among an older ethnically diverse screening population: implications for de-implementation
Authors: Austin Jessica D. , Tehranifar Parisa , Rodriguez Carmen B. , Brotzman Laura , Agovino Mariangela , Ziazadeh Danya , Moise Nathalie , Shelton Rachel C. 
Published: September 2021

Abstract
Background
There is growing concern that routine mammography screening is overused among older women. Successful and equitable de-implementation of mammography will require a multi-level understanding of the factors contributing to mammography overuse.

Methods
This explanatory, sequential, mixed-methods study collected survey data (n= 52, 73.1% Hispanic, 73.1% Spanish-speaking) from women ≥70 years of age at the time of screening mammography, followed by semi-structured interviews with a subset of older women completing the survey (n=19, 63.2% Hispanic, 63.2% Spanish-speaking) and providers (n=5, 4 primary care, 1 obstetrics and gynecology) to better understand multi-level factors influencing mammography overuse and inform potential de-implementation strategies. We conducted a descriptive analysis of survey data and content analysis of qualitative interview data. Survey and interview data were examined separately, compared, integrated, and organized according to Norton and Chambers Continuum of Factors Influencing De-Implementation Process.

Results
Survey findings show that 87.2% of older women believe it is important to plan for an annual mammogram, 80.8% received a provider recommendation, and 78.9% received a reminder in the last 12 months to schedule a mammogram. Per interviews with older women, the majority were unaware of or did not perceive to have experienced overuse and intended to continue mammography screening. Findings from interviews with older women and providers suggest that there are multiple opportunities for older women to obtain a mammogram. Per provider interviews, almost all reported that reducing overuse was not viewed as a priority by the system or other providers. Providers also discussed that variation in mammography screening practices across providers, fear of malpractice, and monetary incentives may contribute to overscreening. Providers identified potential strategies to reduce overscreening including patient and provider education around harms of screening, leveraging the electronic health record to identify women who may receive less health benefit from screening, customizing system-generated reminder letters, and organizing workgroups to develop standard processes of care around mammography screening.

Conclusions
Multi-level factors contributing to mammography overuse are dynamic, interconnected, and reinforced. To ensure equitable de-implementation, there is a need for more refined and empirical testing of theories, models, and frameworks for de-implementation with a strong patient-level component that considers the interplay between multilevel factors and the larger care delivery process.
Synthesis and anti-oxidant activity of coumarinyl chalcones
Authors: Prasad Raj Keshwar , Loksh Kavita R. 
Published: September 2021

Abstract
Background
The ability to inhibit oxidative stress has been established as the prime mechanism in treatment of several disease conditions. In view of this, two new series of coumarin–chalcone hybrid molecules (5a–o and 6a–o) were synthesized using various aromatic aldehydes. The structures of the compounds were confirmed using IR, 1HNMR and mass spectral analyses. The compounds were evaluated for their antioxidant potential against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals in scavenging assays.

Results
Compounds 5o and 5k exhibited significant antioxidant potential as compared to the standard drug (ascorbic acid).

Conclusions
It can be concluded that the coumarin–chalcone treatment have the potential to be optimized further to generate scaffolds capable to treat many pathological conditions.