bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nano‐Coating Loaded With Leaf and Flowers of Pelargonium graveolens Plant Extract Stabilized With Fenugreek Seed Gum and Soy Protein Isolate in Increasing the Shelf Life of Mutton Fillet
Authors: Ebrahimi Farzad , Habibi Nader , Hosseini Mohammadyar 
Published: December 2024

ABSTRACTIn this study, the extract of leaf and flower of Pelargonium graveolens was obtained using an ultrasonic‐assisted extraction method. The extraction yield and the content of phenolic, flavonoid, and flavonol compounds in the flower extract were higher (13.93%, 74.97 mg GAE g DM−1, 31.93 mg QE g DM−1, and 9.08 mg QEE g DM−1) than leaf extract (10.69%, 67.46 mg GAE g DM−1, 23.04 mg QE g DM−1, and 11.34 mg QEE g DM−1). Both extracts demonstrated antioxidant properties in tests involving the scavenging of DPPH radicals and the ferric reduction assay. Extracts exhibited antimicrobial properties. MIC of flower extract against Staphylococcus aureus and Escherichia coli were 2500 and 5000, while MBC of leaf extract were 15,000, and 20,000 ppm, respectively. The concentration of 2000 ppm of extracts was encapsulated in fenugreek seed gum (FSG) and soy protein isolate (SPI) produced by the emulsification method. All nano‐coatings exhibited a nanometric size range between 172.75 to 255.21 nm, and encapsulation efficiency higher than 80.0% (80.82% to 89.59%). The application of nano‐coatings significantly reduced microbial counts and delayed lipid oxidation in mutton meat during 12 days of cold storage at 4°C, enhancing meat quality and extending shelf life. The inclusion of bioactive compounds like polyphenols in the coatings contributed to antimicrobial and antioxidant effects, decreasing pH levels and preventing spoilage. The findings indicated that the combination of edible FSG and SPI as wall materials with 2000 ppm of P. graveolens extract demonstrated efficacy in implementation bacterial growth and lipid oxidation in fresh mutton meat.
Association of Dietary Intake of Vitamin A With Adolescent Hypertension: A Cross‐Sectional Study Based on NHANES 1999–2018
Authors: Mao Yukang , Chen Lin , Wang Yuli , Wu Lida , Xu Guidong , Kong Xiangqing , Chen Chao , Weng Jiayi 
Published: December 2024

ABSTRACTWe aimed to investigate the association between dietary intake of vitamin A and risk of hypertension during adolescence. We interrogated the National Health and Nutrition Examination Survey (NHANES) database, from which individual‐level data on dietary intake of vitamin A were garnered from 13,909 adolescents (aged 10–19 years) participating in the 1999–2018 study cycle. After dividing vitamin A intake into four quartiles, we leveraged weighted multivariate logistic regression to investigate the association of vitamin A intake with hypertension by each quartile, with the restricted cubic spline (RCS) curve plotted to assess the nonlinearity of association. Additionally, we performed subgroup analysis to examine whether gender remarkably affects vitamin A's effect on hypertension. Of all the adolescent participants, 1477 (10.6%) were found to have hypertension. Following thorough adjustments for confounding factors, per 1‐SD increment in vitamin A intake was associated with a 23%, 26%, and 31% reduction in the risk of hypertension for the 2nd, 3rd, and 4th quartiles, respectively. Consistently, the RCS curve indicated that the risk of adolescent hypertension presented a decreasing trend as vitamin A intake creeped up. Intriguingly, gender‐stratified subgroup analysis demonstrated that the observed association between vitamin A and adolescent hypertension was more pronounced in boys. Together, our findings outlined vitamin A as a protective dietary factor against hypertension among US adolescents. When using vitamin A supplements for preventing hypertension, boys may gain more practical benefits.
The Improvement Effects of Sika Deer Antler Protein in an Alzheimer's Disease Mouse Model via the Microbe–Gut–Brain Axis
Authors: Li Lei , Wang Lulu , Ding Weixing , Wu Jianfa , Liu Fei , Liu Jiansong , Zhang Jing , Wang Jing 
Published: December 2024

ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder of the central nervous system. The interplay between the intestinal microbiota and metabolites is believed to influence brain function and the pathogenesis of neurodegenerative conditions through the microbe–gut–brain axis. Sika deer antler protein possesses neuroprotective properties; however, the precise mechanism by which it improves AD remains unclear. Sika deer antler protein ameliorated AD in vivo by activating the phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (AKT)/nuclear factor erythroid 2–related factor 2 (Nrf2) signaling pathway. The metabolome of brain and intestinal tissues and the microbiota of intestinal contents were tested and analyzed according to the microbe‐gut‐brain theory. Sika deer antler protein increased beneficial bacterial levels and decreased harmful bacterial levels. Correlation analyses using the gut flora–metabolomics pathway ultimately revealed that sika deer antler protein modulated the brain and intestinal tract bi‐directionally via the tyrosine metabolism pathway, thereby establishing a connection within the microbe–gut–brain axis. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of the differential metabolite targets of the DAP4 group showed that the enriched pathways mainly included PI3K/AKT, which was consistent with the findings of the pharmacodynamic mechanisms observed in in vivo experiments. This suggests that antler protein may be involved in microbe‐gut‐brain interactions through tyrosine metabolism and may improve AD by activating the PI3K/AKT/Nrf2 signaling pathway. These findings add to our understanding of the microbe–gut–brain axis facilitated by sika deer antler protein and offer novel insights for further research on sika deer antler protein in alleviating AD.
Optimizing Printability of Rice Protein‐Based Formulations Using Extrusion‐Based 3D Food Printing
Authors: Nguyen Thuy Trang , Ahmadzadeh Safoura , Schöberl Helmut , Ubeyitogullari Ali 
Published: December 2024

ABSTRACTThe purpose of this study was to investigate the application of an innovative extrusion‐based 3D food printing (3DFOODP) technique in developing rice protein‐starch (RP‐S) gel‐based products. The effects of 3DFOODP conditions were examined, which included variations in the concentrations of rice protein (RP) and corn starch (S) (15, 17.5, and 20 wt.%), nozzle size (0.8, 1.5, and 2.5 mm), printing temperature (40°C, 60°C, and 80°C), and ingredient flow speed (5.7, 6.3, and 6.9 mL/min). A hollow cylindrical model was chosen as a test object to determine the printability of RP‐S gels. The best 3D printability was achieved using an RP concentration of 17.5% and an S concentration of 15% at 60°C printing temperature with a nozzle size of 1.5 mm, and ingredient flow speed of 6.3 mL/min. With increasing the RP concentration, a rise in apparent viscosity, loss, and storage moduli was observed. The recovery test showed the gels' rapid and reversible response. The freeze‐dried 3D‐printed RP‐S gels showed a porous granular structure, depending on the printing temperature. No chemical interactions between the RP and S were observed as analyzed by FTIR. Overall, RP, in combination with S, provides a new opportunity for the 3DFOODP and their utilization by the alternative protein industry.
Exploring the Anticancer Effect of Artemisia herba‐alba on Colorectal Cancer: Insights From Eight Colorectal Cancer Cell Lines
Authors: Bou Malhab Lara J. , Harb Amani A. , Eldohaji Leen , Taneera Jalal , Al‐Hroub Hamza M. , Abuhelwa Ahmad , Alzoubi Karem H. , Abu‐Irmaileh Bashaer , Hudaib Mohammad , Almaliti Jehad , Abdel‐Rahman Wael M. , Shanableh Abdallah , Semreen Mohammad H. , El‐Huneidi Waseem , Abu‐Gharbieh Eman , Bustanji Yasser 
Published: December 2024

ABSTRACTColorectal cancer (CRC) is a prevalent and deadly disease, necessitating the exploration of novel therapeutic strategies. Traditional chemotherapy often encounters drug resistance and adverse side effects, highlighting the need for alternative approaches. Artemisia herba‐alba, a plant rich in phytochemical constituents, was investigated for its potential as an anticancer agent against colorectal cancer (CRC). The primary objective of this study was to investigate the cytotoxic effects of the methanolic extract of A. herba‐alba on eight CRC cell lines including: Caco‐2, DLD1, RKO+/+p53, RKO−/−p53, HCT+/+p53, HCT−/−p53, SW620, and SW480. Specifically, the study investigated the extract's impact on cell viability, apoptosis, cell cycle progression, and effects on the PI3K/AKT/mTOR signaling pathway. Chemical derivatization and Gas Chromatography–Mass Spectrometry (GC–MS) analysis revealed a diverse array of bioactive compounds, including ephedrine, hydroxyflavone, quinolinic acid, 4‐hydroxybenzoic acid, borneol, β‐eudesmol, and camphor, known for their cytotoxic properties. The methanolic extract of A. herba‐alba exhibited varying degrees of cytotoxicity across a panel of CRC cell lines, with IC50 values indicating differential sensitivity. The extract triggered apoptosis in many cell lines, irrespective of p53 status. Importantly, A. herba‐alba extract caused G2‐M phase cell cycle arrest in CRC cells, accompanied by a decrease in Cyclin B1 and CDK1 expression. Furthermore, the extract demonstrated an inhibitory effect on the PI3K/AKT/mTOR pathway, crucial in cancer progression. These findings highlight the promising anticancer potential of Artemisia herba‐alba as a valuable resource for innovative CRC treatments. Further research is warranted to elucidate its specific anticancer characteristics and explore its potential incorporation into future cancer therapy approaches.
Geriatric Nutritional Risk Index and Postoperative Outcomes Following Head and Neck Cancer Surgery
Authors: Kaki Praneet C. , Patel Aman M. , Brant Jason A. , Cannady Steven B. , Rajasekaran Karthik , Brody Robert M. , Carey Ryan M. 
Published: December 2024

ABSTRACTBackgroundThe geriatric nutritional risk index (GNRI) is a tool to assess preoperative nutritional status that can be calculated simply based on height, weight, and serum albumin. This study assesses the utility of GNRI in predicting postoperative complications in patients undergoing major head and neck cancer (HNC) surgery.MethodsRetrospective review of the 2016–2020 National Surgical Quality Improvement Program database. Patients were categorized into GNRI > 98 (normal nutritional status), GNRI 92–98 (moderate malnutrition status), and GNRI < 92 (severe malnutrition status). Univariable and multivariable binary logistic regression analyses were performed.ResultsSixteen thousand seven hundred eight‐nine patients undergoing HNC resection were included. On multivariable analysis, moderate and severe malnourishment based on GNRI remained significantly associated with any surgical complication, any medical complication, any complication, Clavien‐Dindo grade IV complications, and 30‐day mortality.ConclusionsGNRI may have utility as a potentially modifiable preoperative prognostic factor that can be optimized to improve complications and mortality following HNC resection.Level of EvidenceLevel 4.
On TRacK With Larotrectinib in a Neonate With a Giant Congenital ETV6::NTRK3 Fusion‐Positive Infantile Fibrosarcoma of the Head and Neck
Authors: Cardesa‐Salzmann Teresa M. , Sparber‐Sauer Monika , Hingst Peter , Erbersdobler Andreas , Schneider Bjoern , Hühns Maja , Jakob Andre , Terpe Friederike , Spang Christian , Stalmann Dorothea , Bierwirth Claudia , Hauenstein Christina , Märzheuser Stefanie , Ballmann Manfred , Classen Carl Friedrich 
Published: December 2024

ABSTRACTBackgroundInfantile fibrosarcoma (IFS) is a rare pediatric tumor of intermediate malignancy with high local aggressiveness that typically presents in young infants. Its occurrence in the head and neck region is rare. Complete non‐mutilating surgical resection is often not possible, requiring multimodal treatment. IFS frequently harbors neurotrophic receptor tyrosine kinase (NTRK) fusions. Targeted therapy with NTRK inhibitors is modifying treatment paradigms of IFS.MethodsHerein, we report the case of a neonate with a giant unresectable congenital ETV6::NTRK3 (+) IFS of the head and neck region without rapid response to chemotherapy who was treated with larotrectinib oral suspension.ResultsLarotrectinib was well tolerated and induced an impressive clinical and radiologic response.ConclusionsThis case illustrates an example of pediatric precision oncology in a neonate with an ETV6::NTRK3 (+) congenital IFS of the head and neck region and provides further reference for the use of larotrectinib in the neonatal period.
Exploring the Active Lithium Loss in Anode‐Free Lithium Metal Batteries: Mechanisms, Challenges, and Strategies
Authors: Duan Xuzhi , Sun Jinran , Shi Liang , Dong Shanmu , Cui Guanglei 
Published: December 2024

AbstractAnode‐free lithium metal batteries (AFLMBs), also known as lithium metal batteries (LMBs) with zero excess lithium, have garnered significant attention due to their substantially higher energy density compared to conventional lithium metal anodes, improved safety characteristics, and lower production costs. However, the current cycling stability of AFLMBs faces formidable challenges primarily caused by significant lithium loss associated with the deposition of lithium metal. Therefore, this review focuses on the crucial aspects of lithium metal nucleation and growth on the anode side. Respectively, aiming to provide an in‐depth understanding of the deposition mechanisms, comprehensively summarize the corresponding scientific influencing factors, and analyze specific strategies for addressing these issues through the integration of relevant exemplary cases. Importantly, this review endeavors to offer a profound explication of the scientific essence and intricate mechanisms that underlie the diverse modification strategies. This review possesses the inherent capacity to greatly facilitate the progress and enlightenment of research in this field, offering a valuable resource for the researchers.
Reassessing the Predictive Power of the Yield Spread for Recessions in the United States
Authors: Coe Patrick J. , Vahey Shaun P. 
Published: December 2024

ABSTRACTRudebusch and Williams (2009) predict recessions in the United States utilising a probit model with the lagged yield spread as a real‐time predictor. Mindful of the importance of recent yield curve movements, we update their analysis and evaluate quarterly forecasts from their probit model up to the end of 2023. We also analyze lagged financial conditions as an alternative real‐time predictor. We find that both the yield spread and financial conditions perform relatively well at the longer horizons considered by the experts in the Survey of Professional Forecasters.
Femoral anteversion as a potential risk factor for anterior cruciate ligament injuries in athletes
Authors: Mirahmadi Alireza , Hosseini‐Monfared Pooya , Salimi Maryam , Kazemi Arya , Ghanbari Naser , Shameli Vahid , Kazemi Seyed Morteza 
Published: December 2024

AbstractPurposeNon‐contact anterior cruciate ligament (ACL) injuries are influenced by the anatomic and biomechanical characteristics of the lower limb. The combination of knee valgus, hip internal rotation and tibial external rotation are important contributors to non‐contact ACL injuries. In this study, we aimed to evaluate the effect of femoral anteversion on the incidence of ACL injuries among athletes.MethodsA retrospective comparative study was conducted on 137 adult male athletes with high suspicion of ACL injury following a sports‐related injury. The patients were classified into two groups based on the presence of ACL tears: the ‘ACL tear’ and the ‘ACL intact’ groups. The femoral anteversion angle was measured by both a computed tomography (CT) scan using the method described by Hernandez et al. and a physical examination using Craig's test. The association of ACL tears with femoral anteversion angle was evaluated. Femoral anteversion cut‐off values were calculated to find the best margin for a high probability of ACL tearing.ResultsThe mean anteversion in patients with ACL tears was found to be higher compared to ACL‐intact patients both in CT scan measures (18.4 ± 5.5 vs. 12.9 ± 6.9, p value < 0.001) and physical examination (20.2 ± 5.9 vs. 14.8 ± 7.7, p value < 0.001). The correlation analysis revealed an excellent correlation between femoral anteversion measured by CT scan and Craig's test results (r = 0.94). Cut‐off values for femoral anteversion measured by CT scan concerning ACL tearing with the highest sensitivity and specificity were 12.7 and 19.0, respectively. The Craig‐measured cut‐off values were 1.5–2° more than the CT scan measurements.ConclusionThis study reveals a significant correlation between increased femoral anteversion and a higher risk of ACL injury among male athletes. The results of this study aid in designing personalized prevention programmes for non‐contact ACL injuries among athletes.Level of EvidenceLevel III.
Antiviral and Immunomodulatory Effects of Zafirlukast Against Flaviviruses via Inhibition of the TNF Signaling Pathway
Authors: Komarasamy Thamil Vaani , Gilbert‐Jaramillo Javier , Adnan Nur Amelia Azreen , James William S. , Balasubramaniam Vinod RMT. 
Published: December 2024

ABSTRACTThe two most clinically important members of the flavivirus genus, Zika virus (ZIKV) and dengue virus (DENV) pose a significant public health challenge. They cause a range of diseases in humans, from hemorrhagic to neurological manifestations, leading to economic and social burden worldwide. Nevertheless, there are no approved antiviral drugs to treat these infections. Zafirlukast is an orally available Food and Drug Administration (FDA) approved drug for the prophylaxis and treatment of chronic asthma. It is a leukotriene receptor antagonist (LTRA) with high selectivity of the cysteinyl leukotriene‐1 receptor (CYSLTR1) that acts as an immune modulator. Thus, we evaluated the antiviral potential of Zafirlukast against ZIKV and DENV in SK‐N‐SH cells. We showed that Zafirlukast exhibited potent antiviral activity against ZIKV, which could be linked to Zafirlukast's immune blockade of TNF signaling pathways and its downstream signaling pathways such as MAPK and ERK1/2. In addition, our results showed that Zafirlukast also counteracts ZIKV‐induced changes in key genes involved in cellular lipid metabolism. Thus, these findings highlight the translational potential of optimizing Zafirlukast as a therapeutic agent for the treatment of ZIKV and DENV.
Forecasting Drought Phenomena Using a Statistical and Machine Learning‐Based Analysis for the Central Anatolia Region, Turkey
Authors: Türkeş Murat , Özdemir Ozancan , Yozgatlıgil Ceylan 
Published: December 2024

ABSTRACTDrought is a major concern in Turkey, significantly affecting agriculture, water resources and the economy, especially in the Central Anatolia region with a semiarid steppe and dry‐sub‐humid climate. This study aims to develop an optimal forecasting model for Standardised Precipitation Evapotranspiration Index (SPEI) values over various periods (1–24 months) using data from 50 stations in the Central Anatolia region. It compares statistical forecasting and machine learning methods, finding that machine learning algorithms, particularly the Bayesian Recurrent Neural Network, outperform statistical approaches. The results show a consistent increase in drought severity and highlight the robust performance of top models across different SPEI periods. The study provides a benchmark for future research on forecasting models and underscores the need for effective drought mitigation and adaptation strategies. The incorporation of advanced machine learning algorithms, such as the Bayesian Recurrent Neural Network, and their comparison with traditional statistical methods highlight the potential for more accurate and adaptive drought forecasting models.
Diagnostic characteristics of pediatric cyclic vomiting syndrome
Authors: Bujarska Malgorzata , Bora Geetanjali , Li B U. K. , Banda Julie , Thomas Danny , Simpson Pippa , Karrento Katja 
Published: December 2024

AbstractObjectivesCyclic vomiting syndrome (CVS) remains a diagnostic challenge due to its nonspecific presentation despite consensus‐based diagnostic criteria. There is a need for improved, evidence‐based diagnostic criteria. We hypothesized that symptoms differ quantitatively between children with CVS versus other vomiting conditions and that current diagnostic criteria are not sufficiently sensitive for diagnosing CVS.MethodsObservational, prospective study of children ages 3–18 years with unexplained vomiting episodes evaluated in the outpatient gastroenterology clinic, emergency department, and inpatient units at Children's Wisconsin. Parents completed symptom surveys at 0, 3, and 6 months. Diagnostic workup and treatment response were monitored by chart review. A final diagnosis (CVS vs. non‐CVS) was assigned for group comparisons and receiver operating characteristics (ROC) analysis of diagnostic cutoffs.ResultsOf 108 subjects enrolled, 46 CVS and 54 non‐CVS patients were analyzed. The groups reported overall different episode frequencies with more CVS versus non‐CVS (81% vs. 55%) having ≥4 episodes/preceding 12 months (p = 0.013). CVS patients also had longer vomiting episodes (p = 0.03). To distinguish CVS from non‐CVS, ROC analyses demonstrated the highest sensitivity for a frequency of 4–10 episodes/12 months (p = 0.002) and a duration threshold of >2 h (p < 0.001). CVS patients reported specific episode characteristics: photophobia (p = 0.003), diaphoresis (p = 0.002), multiple emeses/hour (p = 0.001), stereotypical episodes (p = 0.008), and continued retching after gastric emptying (p = 0.008). Less than half of CVS patients met Rome IV and North American Society for Pediatric Gastroenterology, Hepatology & Nutrition diagnostic criteria.ConclusionsChildren with CVS display a distinctive vomiting pattern and clinical features compared to other vomiting conditions. Our findings will help improve current diagnostic criteria.
Exclusive enteral nutrition for induction of remission in pediatric Crohn's disease: Short‐ and long‐term tolerance and acceptance
Authors: Sandrine Catto , Emmanuelle Dugelay , Jérôme Viala , Christine Martinez‐Vinson 
Published: December 2024

AbstractObjectivesIn children with mild to moderate Crohn's disease (CD), exclusive enteral nutrition (EEN) is the first‐line treatment. However, adherence to this therapeutic strategy remains challenging because of numerous psychosocial factors. This study aimed to evaluate the short‐term acceptability and long‐term tolerance of EEN.MethodsA single‐center retrospective study involving a pediatric population with CD was conducted at Robert‐Debré Hospital in Paris between December 2023 and March 2024.ResultsThirty‐two patients responded to the questionnaire. developed specifically for this study. It included detailed sections on the EEN received, duration, observed consequences, difficulties encountered by patients and their families, and sociodemographic information. Twenty patients (62%) received oral treatment, while 12 (38%) required a nasogastric tube (NGT). Thirty‐eight percent of the patients prematurely discontinued treatment. Most children reported difficulties related to taste, vomiting, and discomfort caused by the NGT. Fifty‐nine percent of children would recommend treatment due to its rapid effectiveness, despite the challenges posed by the taste and exclusive nature of the diet. Thirty‐two percent of patients reported persistent eating disorders (EDs) long after treatment discontinuation, and 12.5% reported social disorders. Despite strict treatment constraints, children managed to adapt and maintain their daily activities.ConclusionEEN has significant benefits for children with CD; however, its acceptability is mixed owing to dietary and social constraints. Adequate dietary and psychological support is crucial for improving adherence to treatment and preventing EDs in one third of our patients after treatment.