bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angle of inclination and radiation intensity variation effects on the flat plate solar collector’s performance using graphene oxide (GO)-water nanofluid
Authors: Permanasari A A , Putra S A , Puspitasari P , Sukarni S , Zaine S N A , Wahyunengsih W 
Published: September 2021

Abstract
Flat Plate Solar Collector is a special heat exchanger instrument that transforms solar radiation energy into heat energy. Various attempts have been completed to improve the flat plate solar collector’s performance. One of them is by developing advanced heat transfer fluid with better thermophysical properties than base fluid. Further, the flat plate solar collector’s inclination angle and radiation intensity were investigated to identify the most optimal solar radiation angle of incidence. This study discusses the use of a 0.006% graphene oxide-water nanoparticle toward the nanofluid’s thermophysical properties, sufficient radiation intensity of flat plate solar collector performance, as well as the inclination angle of flat plate solar collector toward the collector’s performance. The used radiation intensity variations were 415 W/m2, 515 W/m2 and 615 W/m2. Meanwhile, the radiation used in this study was from a sun simulator 750 W/m2. In each radiation intensity variation, the inclination angle test of 30°, 45°, and 60° for the flat plate solar collector were carried out. This study was expected to discover the best performance of graphene oxide-water nanofluid usage, collector’s inclination angle variation, and radiation intensity variation.
Performance analysis of a H-Darrieus wind turbine for a Naca 0015 Airfoil: CFD and RSM-based design optimization
Authors: Permanasari A A , Budiearso A B , Sukarni S , Puspitasari P , Zaine S N A , Wahyunengsih W 
Published: September 2021

Abstract
With the increasing demand for electrical energy and the depletion of fossil fuel reserves, this situation forces humans to look for alternative renewable energy. The Indonesian region has a very large wind energy potential because it is located in the tropics. The wind turbine is alternative energy based on kinetic energy into electricity. The purpose of this study was to analyze the effect of the number of blades, wind speed, and angle of attack on turbine performance in the form of the efficiency of the H-Darrieus wind turbine using Airfoil NACA 0015. Variations used in this study were the number of blades (3; 4; 5 pieces) and angle of attack (5°; 15°; 25°). The method used in this research is the Computational Fluid Dynamics (CFD) method and the response surface methodology (RSM). The CFD method is used to find the moment pressure and tangential velocity values, while the RSM method is used to find the most optimum variation. The results of this study indicate that a wind turbine with a number of blades 3 pieces, and a turbine angle of attack 11º is the most optimum H-Darrieus wind turbine design with an efficiency of 5.38%.
The forecasting model of discharge at Brantas sub-basin using autoregressive integrated moving average (ARIMA) and decomposition methods
Authors: Idfi G , Yulistyorini A , Rahayuningsih T , Dewi V A K , Setyawan E 
Published: September 2021

Abstract
A watershed is a combination of several rivers and tributaries with certain boundaries that function to drain rainwater into a lake or a sea. One of the hydrological data contained in the watershed is discharge data. If there is incomplete discharge data, it must be extended based on historical data. ARIMA and decomposition are methods that can predict time series data. The purposes of this research are to determine the historical discharge patterns of Brantas Sub-basin, to know the discharge forecasting model of Brantas Sub-basin, to know the results of forecasting Brantas Sub-basin discharge, and to compare the accuracy between ARIMA and decomposition methods. The accuracy is obtained by calculating MSE and RMSE values. The best method is a method that has the smallest MSE and RMSE values. The results of the research showed that Brantas Sub-basin discharge data in 2007-2017 has a seasonal pattern. The best ARIMA model is ARIMA (0,0,3)(1,0,1)12 model, while the best decomposition model is the additive decomposition model. The Decomposition method has better accuracy than the ARIMA method in predicting discharge of Brantas Sub-basin.
Opioid-related emergency department visits and hospitalizations among patients with chronic gastrointestinal symptoms and disorders dually enrolled in the Department of Veterans Affairs and Medicare Part D
Authors: Balbale Salva N , Cao Lishan , Trivedi Itishree , Stulberg Jonah J , Suda Katie J , Gellad Walid F , Evans Charlesnika T , Jordan Neil , Keefer Laurie A , Lambert Bruce L 
Published: September 2021

Abstract

Purpose
We examined the prevalence of, and factors associated with, serious opioid-related adverse drug events (ORADEs) that led to an emergency department (ED) visit or hospitalization among patients with chronic gastrointestinal (GI) symptoms and disorders dually enrolled in the Department of Veterans Affairs (VA) and Medicare Part D.

Methods
In this retrospective cohort study, we used linked national patient-level data (April 1, 2011, to October 31, 2014) from the VA and Centers for Medicare and Medicaid Services to identify serious ORADEs among dually enrolled veterans with a chronic GI symptom or disorder. Outcome measures included serious ORADEs, defined as an ED visit attributed to an ORADE or a hospitalization where the principal or secondary reason for admission involved an opioid. We used multiple logistic regression models to determine factors independently associated with a serious ORADE.

Results
We identified 3,430 veterans who had a chronic GI symptom or disorder; were dually enrolled in the VA and Medicare Part D; and had a serious ORADE that led to an ED visit, hospitalization, or both. The period prevalence of having a serious ORADE was 2.4% overall and 4.4% among veterans with chronic opioid use (≥90 consecutive days). Veterans with serious ORADEs were more likely to be less than 40 years old, male, white, and to have chronic abdominal pain, functional GI disorders, chronic pancreatitis, or Crohn’s disease. They were also more likely to have used opioids chronically and at higher daily doses.

Conclusion
There may be a considerable burden of serious ORADEs among patients with chronic GI symptoms and disorders. Future quality improvement efforts should target this vulnerable population.
Prognostic value of Mortalin correlates with roles in epithelial–mesenchymal transition and angiogenesis in lung adenocarcinoma
Authors: Meng Ziqi , Zhang Rui , Wu Xuwei , Zhang Meihua , Zhang Songnan , Jin Tiefeng 
Published: September 2021

Abstract
Mortalin is involved in the malignant phenotype of many cancers. However, the specific molecular mechanisms involving Mortalin in lung adenocarcinoma remain unclear. In this study, we showed that both Mortalin mRNA and protein are overexpressed in lung adenocarcinoma. In addition, Mortalin overexpression was positively correlated with poor overall survival. In vitro experiments showed that Mortalin silencing inhibited the proliferation, colony formation and migration abilities of A549 and H1299 cells. Mortalin promotes EMT progression, angiogenesis and tumor progression by activating the Wnt/β-catenin signaling pathway. In vivo experiments further confirmed that Mortalin promoted malignant progression of lung adenocarcinoma. Taken together, our data suggest that Mortalin represents an attractive prognostic marker and therapeutic target in lung adenocarcinoma patients.
Automated quantification of vomeronasal glomeruli number, size, and color composition after immunofluorescent staining
Authors: Bahreini Jangjoo Shahab , Lin Jennifer M , Etaati Farhood , Fearnley Sydney , Cloutier Jean-François , Khmaladze Alexander , Forni Paolo E 
Published: September 2021

Abstract
Glomeruli are neuropil-rich regions of the main or accessory olfactory bulbs (AOB) where the axons of olfactory or vomeronasal neurons and dendrites of mitral/tufted cells form synaptic connections. In the main olfactory system, olfactory sensory neurons (OSNs) expressing the same receptor innervate 1 or 2 glomeruli. However, in the accessory olfactory system, vomeronasal sensory neurons (VSNs) expressing the same receptor can innervate up to 30 different glomeruli in the AOB. Genetic mutation disrupting genes with a role in defining the identity/diversity of olfactory and vomeronasal neurons can alter the number and size of glomeruli. Interestingly, 2 cell surface molecules, Kirrel2 and Kirrel3, have been indicated as playing a critical role in the organization of axons into glomeruli in the AOB. Being able to quantify differences in glomeruli features, such as number, size, or immunoreactivity for specific markers, is an important experimental approach to validate the role of specific genes in controlling neuronal connectivity and circuit formation in either control or mutant animals. Since the manual recognition and quantification of glomeruli on digital images is a challenging and time-consuming task, we generated a program in Python able to identify glomeruli in digital images and quantify their properties, such as size, number, and pixel intensity. Validation of our program indicates that our script is a fast and suitable tool for high-throughput quantification of glomerular features of mouse lines with different genetic makeup.
Short- and long-term outcomes in patients operated with total minimally invasive esophagectomy for esophageal cancer
Authors: Hauge Tobias , Førland Dag T , Johannessen Hans-Olaf , Johnson Egil 
Published: September 2021

Summary
At our hospital, the main treatment for resectable esophageal cancer (EC) has since 2013 been total minimally invasive esophagectomy (TMIE). The aim of this study was to present the short- and long-term results in patients operated with TMIE. This cross-sectional study includes all patients scheduled for TMIE from June 2013 to January 2016 at Oslo University Hospital. Data on morbidity, mortality, and survival were retrospectively collected from the patient administration system and the Norwegian Cause of Death Registry. Long-term postoperative health-related quality of life (HRQL) and level of dysphagia were assessed by patients completing the following questionaries: EORTC QLQ-OG25, QLQ-C30, and the Ogilvie grading scale. A total of 123 patients were included in this study with a median follow-up time of 58 months (1–88 months). 85% had adenocarcinoma, 15% squamous cell carcinoma. Seventeen patients (14%) had T1N0M0, 68 (55%) T2-T3N0M0, or T1-T2N1M0 and 38 (31%) had either T3N1M0 or T4anyNM0. Ninety-eight patients (80%) received neoadjuvant (radio)chemotherapy and 104 (85%) had R0 resection. Anastomotic leak rate and 90-days mortality were 14% and 2%, respectively. The 5-year overall survival was 53%. Patients with tumor free resection margins of &gt;1 mm (R0) had a 5-year survival of 57%. Median 60 months (range 49–80) postoperatively the main symptoms reducing HRQL were anxiety, chough, insomnia, and reflux. Median Ogilvie score was 0 (0–1). In this study, we report relatively low mortality and good overall survival after TMIE for EC. Moreover, key symptoms reducing long-term HRQL were identified.
Cervical cancer testing among women aged 30–49 years in the WHO European Region
Authors: Williams Julianne , Rakovac Ivo , Victoria Jocelyn , Tatarinova Tatiana , Corbex Marilys , Barr Ben , Rose Tanith , Sturua Lela , Obreja Galina , Andreasyan Diana , Shukurov Shukhrat , Gahraman Hagverdiyev , Mikkelsen Bente , Berdzuli Nino , Breda João 
Published: September 2021

AbstractBackgroundScreening programs play an important role in a comprehensive strategy to prevent cervical cancer, a leading cause of death among women of reproductive age. Unfortunately, there is a dearth of information about rates of cervical cancer testing, particularly in Eastern Europe and Central Asia where levels of cervical cancer are among the highest in the WHO European Region. The purpose of this article is to report on the lifetime prevalence of cervical cancer testing among females aged 30–49 years from across the WHO European region, and to describe high-level geographic and socioeconomic differences.MethodsWe used data from the European Health Information Survey and the WHO STEPwise approach to Surveillance survey to calculate the proportions of women who were tested for cervical cancer.ResultsThe percentage of tested women ranged from 11.7% in Azerbaijan to 98.4% in Finland, with the lowest percentages observed in Azerbaijan, Tajikistan and Uzbekistan. Testing was lower in Eastern Europe (compared to Western Europe), among low-income countries and among women with lower levels of education.ConclusionEffective cervical cancer screening programs are one part of a larger strategy, which must also include national scale-up of human papilloma virus vaccination, screening and treatment.
Humoral and cellular immunity and the safety of COVID-19 vaccines: a summary of data published by 21 May 2021
Authors: Xu Kun , Dai Lianpan , Gao George F 
Published: September 2021

Abstract
Coronavirus disease 2019 (COVID-19) has caused millions of deaths, and serious consequences to public health, economies and societies. Rapid responses in vaccine development have taken place since the isolation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the release of the viral genome sequence. By 21 May 2021, 101 vaccines were under clinical trials, and published data were available for 18 of them. Clinical study results from some vaccines indicated good immunogenicity and acceptable reactogenicity. Here, we focus on these 18 vaccines that had published clinical data to dissect the induced humoral and cellular immune responses as well as their safety profiles and protection efficacy.
Therapeutic immunoglobulin A antibody for dysbiosis-related diseases
Authors: Shinkura Reiko 
Published: September 2021

Abstract
Dysbiosis is alterations in the microbial composition compared with a healthy microbiota and often features a reduction in gut microbial diversity and a change in microbial taxa. Dysbiosis, especially in the gut, has also been proposed to play a crucial role in the pathogenesis of a wide variety of diseases, including inflammatory bowel disease, colorectal cancer, cardiovascular disease, obesity, diabetes and multiple sclerosis. A body of evidence has shown that intestinal polymeric immunoglobulin A (IgA) antibodies are important to regulate the gut microbiota as well as to exclude pathogenic bacteria or viral infection such as influenza and SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) at mucosal sites. Since the 1970s, trials for oral administration of therapeutic IgA or IgG have been performed mainly to treat infectious enteritis caused by pathogenic Escherichia coli or Clostridium difficile. However, few of them have been successfully developed for clinical application up to now. In addition to the protective function against intestinal pathogens, IgA is well known to modulate the gut commensal microbiota leading to symbiosis. Nevertheless, the development of therapeutic IgA drugs to treat dysbiosis is not progressing. In this review, the advantages of therapeutic IgA antibodies and the problems for their development will be discussed.
Pharmacological effects on anaplerotic pathways alter the metabolic landscape in the tumor microenvironment, causing unpredictable, sustained anti-tumor immunity
Authors: Udono Heiichiro , Nishida Mikako 
Published: September 2021

Abstract
To achieve sustained anti-tumor immunity, tumor-infiltrating effector CD8 T lymphocytes (CD8 TILs) must be able to produce cytokines, including IFNγ, and proliferate robustly within the local tumor tissue upon antigen recognition. IFNγ production by CD8 TILs depends on glycolysis, whereas their proliferation additionally requires oxidative phosphorylation (OxPhos). The level of OxPhos, and hence the oxygen consumption rate, depends on mitochondrial biogenesis and requires the loading of metabolic precursors into the tricarboxylic acid cycle to keep it functioning. This is referred to as anaplerosis. Recent advances in the field of immuno-metabolism have shown the impact of pharmacological agents on anaplerotic pathways, resulting in metabolic down-regulation in tumor cells; in contrast, the agents trigger sustained anti-tumor immunity by up-regulating both glycolysis and OxPhos in CD8 TILs. The opposing effects of pharmacological inhibition (and/or activation) on anaplerosis in tumor cells and CD8 TILs are unpredictable. Careful dissection of the underlying mechanism might confer important knowledge, helping us to step into a new era for cancer immunotherapy.
Using telemedicine to improve the quality of life of parents of infants with CHD surgery after discharge
Authors: Zhang Qi-Liang , Lei Yu-Qing , Liu Jian-Feng , Cao Hua , Chen Qiang 
Published: September 2021

Abstract

Objective
The purpose of this study was to investigate the effect of using telemedicine to improve the quality of life of parents of infants with congenital heart disease (CHD) surgery after discharge.

Methods
A prospective randomized controlled study was conducted in a provincial hospital in China from November 2020 to April 2021 to compare the quality of life of parents of infants with CHD surgery after discharge between the WeChat follow-up group and the outpatient follow-up group. A total of 84 patients (42 in each group) and 168 parents (84 in each group) participated in this study.

Results
One month after discharge, the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores of parents in the intervention group were significantly lower than those in the control group (P &lt; 0.05). Compared with the SAS and SDS scores at discharge, the scores of parents in the intervention group were significantly lower at 1 month after discharge (P &lt; 0.05), while the scores of parents in the control group were similar at 1 month after discharge (P &gt; 0.05). At discharge, in both the intervention group and the control group, the SAS and SDS scores of the mothers were higher than those of the fathers (P &lt; 0.05). One month after discharge, in the control group, the SAS and SDS scores of the mothers were higher than those of the fathers (P &lt; 0.05). One month after discharge, in the intervention group, the SAS and SDS scores of the mothers were similar to those of the fathers (P &gt; 0.05). The comparison of the SAS and SDS scores of parents with different education levels showed that in both the intervention group and control group, the lower the parents’ educational levels, the higher their SAS and SDS scores (P &lt; 0.05). One month after discharge, in the control group, the lower the parents’ education levels, the higher their SAS and SDS scores (P &lt; 0.05). One month after discharge, in the intervention group, the SAS and SDS scores were similar among parents with different educational levels. The results of the World Health Organization Quality of Life Brief scale showed that the scores of the physiological, psychological, social and environmental fields at 1 month after discharge in the intervention group were significantly higher than those in the control group (P &lt; 0.05).

Conclusion
Providing health education and medical support to the parents of infants with CHD surgery after discharge via telemedicine can effectively relieve parents’ anxiety and depression and improve their quality of life.
Technical Note: The comparison of pH and redox potential in different locations in the reticulo-rumen of growing beef steers supplemented with different levels of quebracho extract
Authors: Dias Batista Luiz F , Norris Aaron B , Adams Jordan M , Hairgrove Thomas B , Tedeschi Luis O 
Published: September 2021

Abstract
Rumen acidosis is a common metabolic disorder occurring when organic acid production exceeds clearance capacity, reducing ruminal pH. The occurrence of acidosis has been directly correlated to the ratio of concentrate to forage in the diet. However, rates of substrate fermentation and acid absorption vary at different locations in the reticulo-rumen. The objective of this study was to determine the pH and redox potential (Eh) in different locations of the reticulo-rumen using 16 ruminally cannulated steers (309 ± 43 kg) receiving different supplementation levels of quebracho extract (QT; Schinopsis balansae) within a grower type diet (CP: 13.4%; total digestible nutrients [TDN]: 70.4%; and ME: 2.55 Mcal/kg, dry matter [DM] basis). Animals were randomly assigned to one of four dietary treatments: QT at 0%, 1%, 2%, and 3% of DM (QT0, QT1, QT2, and QT3, respectively), containing about 0%, 0.7%, 1.4%, and 2.1% of condensed tannins (CT), DM basis, respectively. Animals were adapted to the basal diet for 12 d before being introduced to predetermined treatments for 4 weeks (wk), with diets provided twice daily to allow ad libitum intake. Weekly measurements of ruminal fluid pH and Eh were taken 4 h post-feeding using a portable pH meter with two probes (pH and redox) in four locations of the reticulo-rumen (reticulum, cranial sac, dorsal sac, and ventral sac). Data were analyzed using a random coefficients model with the pen as a random effect and wk as repeated measures, with DM intake included as a covariate. There was no interaction among treatments, location, and wk (P ≥ 0.882) on reticulo-ruminal pH. Overall, ruminal pH was lower for QT0 and QT1 compared to QT3 (P &lt; 0.001). The pH in the reticulum was greater than those of the ventral and dorsal sacs (6.05 vs. 5.94, 5.89, respectively; P ≤ 0.001) but similar to cranial sac (6.00). Reticular pH was positively correlated with the ruminal locations (≥0.78; P &lt; 0.001). The linear equation to estimate ruminal mean pH using reticulum pH had an intercept and slope different from zero (P ≤ 0.04), but CT (% DM) was not different from zero (P = 0.15), root mean square error of 0.15, and R2 of 0.778: 0.723 (±0.36) + 0.857 (±0.059) × reticulum pH + 0.033 (±0.023) × CT. The Eh was lower for QT0 in week 1 than all other treatments (P &lt; 0.001). We concluded that reticulo-ruminal pH differs among locations in the rumen regardless of QT supplementation level and days on feed, with reticular pH being the highest.