bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Research of Blast Resistant of Reinforcement Concrete Beams in Concrete Structures at Off-site Oil and Gas Plant
Authors: Aljasmi Salah , Ariffin Nur Farhayu , Abu Seman Mazlan 
Published: November 2021

In the recent decades, blasts and gas explosions at the off-site of oil and gas plants have increased leading to destruction of important concrete structures, essential equipment and loss of human life. In response, structural engineers have come up with different ways of reinforcing beams of concrete structures using fiber reinforced polymers composite materials to produce blast resistant structures to minimize the impact of the blast loads, due to their unique and individual characteristics like high flexural and shear strength. This paper seeks to research the dynamic behavior, response and performance of reinforce concrete beams strengthened with Carbon Fiber Reinforced Polymer composites when subjected to blast loading. The study aims at proposing a design model of strengthening reinforce concrete beams with Carbon Fiber Reinforced Polymer in supporting concrete structures at off-site oil and gas plants against hydrocarbon explosions. Carbon Fiber Reinforced Polymer composites exhibit higher modulus of elasticity, higher energy absorption capacity, resistant to all forms of alkali and higher tensile strength compared to all other fiber reinforced polymers reinforcements and therefore the need to assess its capacity in protecting concrete structures at oil and gas plants against dynamic loads. The research will be carried out through numerical analysis using the finite element analysis computer program, ANSYS.
“Uma trilha para libertação de outros”
Authors: Rocha Vanessa Massoni da , Silva Luciely da 
Published: November 2021

Este artigo se propõe a cartografar a ideia de (não-) pertencimento de personagens negros retratados no livro de contos Olhos d’água (2014), da escritora mineira Conceição Evaristo. Em nossas análises, privilegiaremos três contos da obra, “Duzu-Querença”, “O cooper de Cida” e “Ei, Ardoca”, nos quais se descortinam os matizes da obra, tais como o racismo, o silenciamento, o sofrimento, as dores, o anonimato, a violência e o suicídio. Intenciona-se fomentar o debate a respeito de como os caminhos são negados (ou, ao menos, dificultados) para sujeitos negros no seio da sociedade e, por outro lado, busca-se ressaltar o viés literário como espaço de visibilidade para seres anônimos reiteradamente cantonados. De maneira mais detalhada, pretende-se observar aspectos da tessitura textual de Conceição Evaristo, notadamente no que diz respeito à constituição das vozes narrativas. Para isso, adotamos a perspectiva decolonial (Almeida, Césaire, Kilomba, Salgueiro), ressaltamos as reflexões em torno do feminismo negro (Akotirene, Kilomba, Ribeiro), da necropolítica (Mbembe), da presença dos negros na literatura feminina contemporânea (Dalcastagnè), além de percorrer obras literárias e entrevistas de Evaristo, além de críticas teóricas sobre sua obra.
Safety of diathermy for pedicle de-epithelialization in breast reduction surgery in comparison to surgical blade use
Authors: Netshiongolwe Thendo T , Ndobe Elias , Fru Pascaline N. 
Published: November 2021

ABSTRACT

Background: Pedicle de-epithelialization during breast reduction is traditionally performed using a surgical blade. The reliability of this method is hampered by the time-consuming nature, bleeding and safety concerns. In this study, a comparison of the use of the surgical blade to the diathermy was assessed for blood loss, surgical time and safety during breast reduction procedures at two breast units in Johannesburg, South Africa.
>Methods: Fifteen patients undergoing breast reduction procedures with a total of 30 breasts (n=15 each for diathermy and surgical blade) were reviewed. Surgical swabs were weighed for blood loss differences and procedures were timed. Postoperatively, nipple sensation and nipple viability were determined in all patients. The data was analysed using STATA Version 16.0 suite of analytics software and a p value of <0.05 was considered significant.

Results: The participant ages ranged from 18-59 years with a mean (standard deviation) of 34.0 (±12.8) years. The median and interquartile ranges (IQR) of blood loss from using the surgical blade was significantly higher compared to that of the diathermy at 25.4 mL (11.4-49.4) mL versus 10.0 mL (4.0-20.0) mL, respectively (p=0.003). There were no significant differences in the overall time taken in performing the procedures: surgical blade 13.0 (11.0-21.0) minutes vs diathermy 12.5 (9.0-14.0) minutes (p = 0.27). Apart from a hematoma in one breast in the surgical blade arm, nipple viability was 100% and nipple sensation was 93.3 % (14/15) for both groups.

Conclusion: Despite similar safety profiles between de-epithelialization using diathermy versus surgical blade, the added advantage of significantly lower blood loss using diathermy suggests that the latter be considered over the standard surgical blade method during breast reduction and other procedures involving flaps.
The efficiency of using digital resources for the development of primary school students' linguodidactic potential
Authors: Makharova Gaukhar , Nurzhanova Sazhila , Adilbayeva Ulzhalgas , Dossanova Albina , Aimagambetova Malika 
Published: November 2021

The aim of this research is to evaluate the effects of education given through digital resources on the language didactic potential of students with the views of teachers. 40 primary school teachers who teach 1st-4th grade students in various provinces of Kazakhstan participated in the research. In the research, case study, which is one of the qualitative research methods, was used. The research data were collected through a semi-structured interview form prepared by the researcher in order to get the opinions of the teachers who voluntarily agreed to participate in the research. Research data were analyzed by content analysis technique. As a result of the research, it has been determined that teachers are prone to use technology and partially use digital resources in their lessons. However, teachers stated that they are more open to the use of digital resources if the opportunity is given. In addition, although most of the teachers state that the use of digital resources has no effect on increasing the workload of the teacher, some define it as a workload. Teachers, who believed that it partially increased teacher success, stated that it had a positive effect on student success and student motivation. Research findings reveal that teachers need to receive supportive training on the use of digital resources in education.
Keywords; Digital resources, use of technology in education, linguodidactic potential of students, primary school teachers
Formation of school student’s vocabulary skills through innovative technologies
Authors: Omarovaa Gulnara , Saduakas Gulbanu , Zhumabayeva Aziya , Akzholova Aktoty , Uaisova Gulnar 
Published: November 2021

The aim of this research is to determine the attitudes of elementary school 4th graders regarding electronic books developed through innovative technologies in the development of vocabulary. Qualitative research methods were used in accordance with the purpose of the research. The data of the research were collected by the semi-structured interview form developed by the researcher. The study involved 20 elementary school 4th graders studying in Almaty, Kazakhstan in the 2019-2020 academic year. As a result of the research, it was concluded that students have a moderate tendency to read electronic books and have a tendency to prefer electronic books as much as printed books. In addition, students found electronic books to be easily accessible, easy to learn and advantageous with their ability to be easy to learn, while they found themselves disadvantaged in terms of easy concentration, eye strain and technology addiction. Based on the results of the research, it is recommended to improve electronic books through innovative technologies and to carry out studies on increasing the use of electronic books by students.
Keywords: Electronic book, innovative technologies, student feedback, technology-based learning
Teachers' views on the level of cultural heritage knowledge that can be improved through innovative technologies
Authors: Zhabykbayeva Dinara , Sanay Gaukhar , Bekish Azamat , Zhylkybekova Gulbira , Kasymbekov Zhakypbek 
Published: November 2021

The purpose of this research is to determine primary school students' perceptions of cultural heritage and to evaluate student and teacher views on the level of cultural heritage knowledge that can be improved through innovative technologies. The research was carried out with 20 primary school students and 10 primary school teachers who were educated in the city of Almaty, Kazakhstan in the 2020-2021 academic year. The research was designed in the case study pattern, which is one of the qualitative research methods. The data collection tools of the research were developed by the researcher. Semi-structured student interview form and semi-structured teacher interview form were used to collect data in the research. The analysis of the data was carried out using the content analysis method. The results of the research reveal that the students have a good grasp of some concepts related to the definition of cultural heritage and they partially know the tangible cultural heritage and intangible cultural heritage items. While the teachers did not find the cultural heritage education sufficient, they stated that an education through innovative technologies would increase the level of student knowledge and made suggestions regarding this. Research findings reveal the necessity of using innovative technologies in cultural heritage education and accordingly the need for new regulations in education programs.
Keywords; Cultural heritage, Innovative technologies, Cultural heritage education, Student knowledge level.
Characteristics and Prognosis of Antibody Non-Responders with COVID-19
Authors: Ding JunYu , Liu Changxin , Wang Zhao , Guo Hua , Zhang Kan , Ma Lin , Wang Bo , Zhao Huijun , Song ManYa , Guan Xizhou 
Published: November 2021

Abstract
Background：The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been spreading globally. The information regarding the characteristics and prognosis of antibody non-responders with COVID-19 is scarce.Method: In this retrospective, single-center study, we included all the patients with confirmed COVID-19 using real-time reverse transcriptase-polymerase chain reaction (RT-PCR) admitted to the Fire God Mountain hospital from February 3, 2020, to April 14, 2020. A total of 1921 patients were divided into the antibody-negative group (n=94) and antibody-positive group (n=1827), and the 1:1 propensity score matching (PSM) was used to match two groups.Results: In the antibody negative group, 40 patients (42.6%) were male, 54 patients (57.4%) were female, and 49 patients (52.1%) were older than 65 years old. Cough was the most common symptoms in the antibody negative group. White blood cell counts (WBC) 6.6×109/L [5.0, 9.1], Neutrophils 4.3×109/L [3.1, 6.6], C-reactive protein 7.3 mg/L [1.3, 49.0], Procalcitonin (PCT) 0.1 ng/mL [0.0, 0.2], Interleukin-6 (IL-6) 64.2 [1.5, 28.7], Lactate dehydrogenase (LDH) 193.8 U/L [154.9,260.6], Creatine kinase 60.5 U/L [40.5, 103.7], Creatine kinase isoenzyme 10.3 ng/mL [8.2, 14.5], Urea nitrogen 5.3 mmol/L [4.0, 8.7] and Creatinine 77.7 μmol/L [60.6, 98.7] were significantly higher in antibody negative patients than in antibody positive group (P<0.005). The days of nucleic acid negative conversion in the antibody negative group was shorter than that in the antibody positive group (P < 0.001). Meanwhile, the hospitalization time of antibody negative patients was shorter than that of antibody positive patients (8.0 [6.0, 10.0] VS 13.0 [8.2, 23.0], P < 0.001).Conclusion: Some COVID-19 patients without specific antibodies had mild symptoms, but the inflammatory reaction caused by innate clinical immunity was more intense than those with antibodies, and the virus was cleared faster. The production of specific antibodies was unnecessary for SARS-CoV-2 clearance, and non-specific immune responses played an essential role in virus clearance.
Heuristic Approaches With Reinforced Parameter Tuning for the Car Sequencing Problems With Block Batches
Authors: Yu Yingjie , Lu Xiaochun , Zhao Tao , Cheng Minjiao , Liu Lin , Wei Wenchao 
Published: November 2021

Abstract
Motivated by the practical supply chain management of the automobile industry, we study the car sequencing problem (CSP) that minimize the conflicts arising from scheduling cars into an assembly line. The CSP is a well established problem, subject to the paint batching constraints to reduce the the costs for color changes and capacity constraints in the assembly shop to level the usage of the options. However, the existing approaches to this problem do not take into account the block batches, which desires a consecutive production batch of cars requiring a certain option. This requirement often occurs when specialized labor time window is short in the customized car production scenario, and renders additional complexities to the traditional car sequencing problem. In this paper, we propose a novel model to deals with these constraints and simultaneously generate the sequencing and replenishment decisions. In addition to our model formulation, we develop two math-heuristic approaches to solve the propose large-scale car sequencing problem. The selected heuristics are based on relax-and-fix procedures, fix-and-optimize procedures and variable neighborhood search. To solve the large-sized instances (commercial solvers, i.e., Cplex, cannot provide a feasible solution within 1 hour), we design and implement a reinforced parameter tuning mechanism to dynamically select the parameter values, so as to speed up the search process. The proposed models and heuristics are tested on compatible instances from the benchmark in the literature (CSPLib), as well as large-sized instances generated from real-world cases. We report on extensive computational experiments, and provide basic managerial insights into the planning process.
Abandonment of Patients in Emergency Department of Tertiary Care Hospital of Eastern Nepal- an Observational Study
Authors: CHAUDHARY RITESH , Bhandari Rabin , Giri Saroj , Shrivastav Vijay , Bhandari Rupak 
Published: November 2021

Abstract
Background

Patient abandonment in the emergency department has been reported in various parts of the world although the implications and social circumstances may vary in context to its definition. The current study intends to review the characteristics of twenty- four (24) abandoned patients in the emergency department of tertiary care hospital of Eastern Nepal.
Methods

This was a prospective observational study conducted among all abandoned patients presenting to tertiary care hospital in eastern Nepal from July 2018 to July 2020.
Results

Twenty four (24) patients were enrolled in the study. 22 (91.7%) were male and 2 (8.3%) were female with a mean age of 43.2 ± 14.4SD. The median length of stay (LOS) was 72 (Q1, Q3, 23.5, 960) hours in the emergency department. Seven, 7 (43.75%) cases of mortality were due to medical illness, 4 (25%) cases of mortality were due to surgical illness and 5 (31.25%) cases of mortality were with undifferentiated presentations (p= 0.012). 15 of 24 (62.5%) patients over 40 years of age experienced a longer LOS (p = 0.34) and (75%) 12 of 16 have a higher mortality than younger patients (p= 0.30). More than (USD) $50 was invested in an abandoned case that was taken care of by NGOs. 6 (25%) of abandoned patients were taken care of by other centers like NGOs and welfare centers.
Conclusions

Abandoned patients in the middle-aged adults with medical comorbidity experienced longer hospital stays and as an indicator of mortality. Financial disparities were observed among abandoned patients taken care of by charitable organizations and tertiary care hospital.
Genetic Mapping of Powdery Mildew Resistance Genes in Wheat Landrace ‘Guizi 1’ Using Genotyping-By-Sequencing
Authors: Li Luhua , Yang Xicui , Wang Zhongni , Ren Mingjian , An Chang , Zhu Susong , Xu Ruhong 
Published: November 2021

Abstract
Wheat powdery mildew (Pm), caused by Blumeria graminis f. sp. tritici (Bgt), is a destructive disease of wheat (Triticum aestivum L.) worldwide that causes severe yield losses. Resistant wheat cultivars easily lose effective resistance against newly emerged Bgt strains; therefore, identifying new resistance genes is necessary for breeding resistant cultivars. ‘Guizi 1’ is a Chinese wheat cultivar with effective moderate and stable resistance against powdery mildew. A genetic analysis indicated that powdery mildew resistance in ‘Guizi 1’ was controlled by a single dominant gene, designated PmGZ1. In total, 110 F2 individual plants and the 2 parents were used for genotyping-by-sequencing, which produced 23,134 high-quality single-nucleotide polymorphisms (SNPs). The SNP distributions on the 21 chromosomes ranged from 134 on chromosome 6D to 6,288 on chromosome 3B. Chromosome 6A has 1,866 SNPs, among which 16 are located in a physical region between positions 307,802,221 and 309,885,836 in an approximate 2.3-cM region, which possessed the greatest SNP density. The average map distance between SNP markers was 0.1 cM. A quantitative trait locus with a significant epistatic effect on powdery mildew resistance was mapped to Chromosome 6A. The LOD value of PmGZ1 reached 34.8, and PmGZ1 was located within the confidence interval marked by chr6a-307802221 and chr6a-309885836. The phenotypic variance explained by PmGZ1 was 74.7%. Four candidate genes (two each encoding TaAP2-A and actin proteins) were annotated as resistance genes. The present results provide valuable information for wheat genetic improvement, quantitative trait loci fine mapping, and candidate gene validation.
Repopulating Kupffer Cells Originate Directly from Hematopoietic Stem Cells
Authors: Fan Xu , Lu Pei , Cui Xianghua , Wu Peng , Lin Weiran , Zhang Dong , Yuan Shunzong , Liu Bing , Chen Fangyan , You Hong , Wei Handong , He Fuchu , Jia Jidong , Jiang Ying 
Published: November 2021

Abstract
Kupffer cells (KCs) originate from yolk sac progenitors before birth, but the origin of repopulating KCs in adult remains unclear. In current study, we firstly traced the fate of preexisting KCs and that of monocytic cells with tissue-resident macrophage-specific and monocytic cell-specific fate mapping mouse models, respectively, and found no evidences that repopulating KCs originate from preexisting KCs or MOs. Secondly, we performed genetic lineage tracing to determine the type of progenitor cells involved in response to KC depletion in mice, and found that in response to KC depletion, hematopoietic stem cells (HSCs) proliferated in the bone marrow, mobilized into the blood, adoptively transferred into the liver and differentiated into KCs. Finally, we traced the fate of HSCs in a HSC-specific fate-mapping mouse model, in context of chronic liver inflammation induced by repeated carbon tetrachloride treatment, and confirmed that repopulating KCs originated directly from HSCs. Taken together, these findings provided in vivo fate-mapping evidences that repopulating KCs originate directly from hematopoietic stem cells, which present a completely novel understanding of the cellular origin of repopulating Kupffer Cells and shedding light on the divergent roles of KCs in liver homeostasis and diseases.
Availability of CT on island medical facilities: Association with mortality in patients evacuated via long-distance air medical transport
Authors: Ishihata Ayaka , Nakajima Mikio , Ono Sachiko , Kaszynski Richard H , Takane Ryo , Shirokawa Masamitsu , Otawara Masayuki , Nakano Tomotsugu , Goto Hideaki 
Published: November 2021

Abstract
Background

To examine the association between availability of computed tomography (CT) and severity-of-disease/mortality in patients evacuated via long-distance emergency air medical transport from island medical facilities.
Methods

We retrospectively and consecutively enrolled patients transferred via rotary- or fixed-wing aircraft from island medical facilities to a designated emergency medical center in Tokyo, Japan between 2010 and 2020. Airlifted patients were divided into two groups, depending on the availability of CTs on the island facilities in which they were transported from. The outcomes were severity-of-disease after air medical transport and in-hospital mortality. We examined the association between these outcomes and the availability of CTs on each island facility.
Results

Eligible patients (n=1,880) were categorized into the CT (n=1,744) or non-CT group (n=136). After adjusting for age, sex, diagnostic category and flight time, the CT group was significantly associated with greater severity of disease (coefficient, 1.30; 95% confidence interval, 0.13–2.47). In contrast, significant reductions in mortality were not documented in the CT group.
Conclusion

While the availability of CTs was significantly associated with greater severity of disease, CT availability did not significantly impact mortality in patients transferred from island medical facilities.
The Expression of Oct3/4A mRNA and Not Its Isoforms is Upregulated by the HPV16 E7 Oncoprotein
Authors: Gómez-Gómez Yazmín , Organista-Nava Jorge , Clemente-Periván Sayuri Itzel , Lagunas-Martinez Alfredo , Salmerón-Bárcenas Eric Genaro , Villanueva-Morales Daniel , Ayala-Reyna Dania Yahaira , Alarcón-Romero Luz del Carmen , Ortiz-Ortiz Julio , Jiménez-López Marco Antonio , Illades-Aguiar Berenice 
Published: November 2021

Abstract
Oct3/4 a transcription factor is involved in maintaining the characteristics of cancer stem cells. Oct3/4 can be expressed differentially with respect to the progression of CC. In addition, Oct3/4 can give rise to three isoforms by alternative splicing of the mRNA Oct3/4A, Oct3/4B and Oct3/4B1. The aim of this study was to evaluate the mRNA expression from Oct3/4A, Oct3/4B and Oct3/4B1 in low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL), cervical cancer (CC) samples, and measure the effect of the HPV16 E7 oncoprotein on the mRNA expression from Oct3/4 isoforms in the C-33 A cell line. The expression levels of Oct3/4A, Oct3/4B and Oct3/4B1 mRNA were analyzed by reverse transcription quantitative polymerase chain reaction (RT-qPCR) in patients with LSILs, HSILs and CC. Additionally, C-33 A cells that expressed the HPV16 E7 oncoprotein were established to evaluate the effect of E7 on the expression of Oct3/4 mRNA isoforms. Oct3/4A (p=0.02), Oct3/4B (p=0. 001) and Oct3/4B1 (p<0. 0001) expression is significantly higher in patients with LSIL, HSIL and CC than in woman with non-IL. In the C-33 A cell line, the expression of Oct3/4A mRNA in the presence of the E7 oncoprotein increased compared to that in nontransfected C-33 A cells. Oct3/4B and Oct3/4B1 mRNA were expressed at similar levels among the different groups. These data indicate that only the mRNA of Oct3/4A is upregulated by the HPV16 E7 oncoprotein.