bluuebunny/crossref_metadata_2025_split huggingface dataset:
The insect somatostatin pathway gates vitellogenesis progression during reproductive maturation and the post-mating response
Authors: Zhang Chen , Pérez Crisalejandra Rivera , Noriega Fernando , Kim Young Joon 
Published: April 2021

Abstract
Oogenesis is closely linked with reproductive maturation and mating status in females. In the fruit fly Drosophila melanogaster, vitellogenesis (yolk accumulation) is an important control point for oogenesis. Vitellogenesis begins upon eclosion and continues through the process of sexual maturation. Upon reaching sexual maturity, vitellogenesis is placed on hold until it is induced again by a mating signal. In flies, this mating signal is sex peptide (SP), a seminal substance that triggers robust egg-laying activity. However, the neural mechanisms that gate vitellogenesis in response to developmental and reproductive signals remain unclear. Here, we have identified a pair of thoracic ganglion neurons that produce the neuropeptide allatostatin C (AstC-mTh). AstC inhibits the biogenesis of juvenile hormone (JH), a key endocrine stimulator of vitellogenesis. Our genetic evidence indicates that AstC-mTh neurons gate both the initiation of vitellogenesis that occurs post-eclosion and its re-initiation post-mating. During sexual maturation, which takes place shortly after eclosion, AstC-mTh neurons are activated by excitatory inputs from SP abdominal ganglion (SAG) neurons. In mature virgin females, high sustained activity of SAG neurons seems to shut off vitellogenesis via continuous activation of the AstC-mTh neurons. Upon mating, however, SP inhibits SAG neurons, leading to AstC-mTh neuronal activation. As a result, the inhibition of the CA maintained by the AstC neurons is lifted. This permit both JH biosynthesis and the progression of vitellogenesis in mated females. Our work has uncovered a central neural circuit that gates the progression of oogenesis during sexual maturation and the post-mating response.
Implementing advance care planning in dementia care: results and insights from a pilot interventional trial
Authors: Bosisio Francesca , Sterie Anca , Truchard Eve Rubli , Jox Ralf J. 
Published: April 2021

Abstract
Background: Advance care planning (ACP) is particularly appropriate for persons with dementia (PWD) since it fosters conversation about dementia-specific illness scenarios, addresses inconsistencies between advance directives and patients’ observed behaviour, emphasises prospective and relational autonomy, and may be generally consistent to elderly’s decision-making needs. However, despite the evidence of its benefits, ACP is yet to become widely used among PWD. In this paper, we present results regarding the feasibility and acceptability of a pilot intervention designed to foster ACP among PWD and their relative and explore future outcome measures in prevision of a randomized controlled trial. Methods: In order to assess pre-post variations, we used qualitative interviews and four psychometric scales: Hospital Anxiety and Depression Scale, Questionnaire of Psychological Autonomy, Decisional conflict scale, and Zarit burden scale. We added two visual analog scales for perceived control over and perceived involvement in healthcare decisions, as well as two hypothetic scenarios to test concordance between PWD’s and surrogate’s decisions.Results: Five main challenges in terms of feasibility were 1) to locate eligible patients, 2) to tailor recruitment procedures to recruitment locations, 3) to adapt inclusion criteria to meet clinical routines, 4) to engage PWD and their relatives in ACP, and 5) to choose outcome criteria that do not burden PWD. Alongside with those expected challenges, we discuss substantial unanticipated gatekeeping by the research ethics committee and healthcare professionals. Despite the setbacks, the intervention was well received by PWD and their relatives that expressed satisfaction with the procedure, especially in regard to the opportunity to discuss a sensitive topic with the help of a facilitator. Relatives’ perceived control over healthcare decisions increased, as well as concordance between PWD’s preferences and relatives’ decision. Conclusion: Misconceptions about dementia and ACP, both in the patient, relatives, and healthcare providers, combined with structural institutional challenges, have the power to impede research and implementation of ACP in dementia care. For this reason, we advocate for a systemic approach of ACP and for the use of ACP tools and research adapted to PWD cognitive capacities.Trial registration: This trial was registered in the database clinicaltrial.gov with the number NCT03615027
Sugeno Fuzzy Model Free Reinforced Transformation Based Data Processing for Healthcare Sources in IoT Environment
Authors: Veerappan Sellam , Natarajan Kannan , Gopu Arunkumar , Sekaran Ramesh , Ramachandran Manikandan , Bhaskar Vidhyacharan 
Published: April 2021

Abstract
Modern computer sciences and information technologies are anticipated to bring transformative influence in part that mobile communication technologies play in society. To completely take advantage of the services bestowed by modern computer sciences and information technologies, the evidence of the economic and business case is an essential prerequisite. Existing research engulfs several transformative computing methods based on sensors area obtainable as service contain optimize resource management, data processing/storage and security provisioning. With transformative computing being on edge, real-time data must be necessitated for healthcare data analytics. The conventional cloud server cannot address the latency requirements of healthcare IoT sensors. To survive with how to handle these services, we introduce a hybrid method integrating Sugeno Fuzzy Inference (SFI) and Model-free Reinforcement Learning to enhance healthcare IoT and cloud latency. The objective is to lessen high latency between healthcare IoT devices. The proposed Sugeno Fuzzy Model-free Reinforcement Learning Data Computing (SF-MRLDC) method uses a Sugeno Fuzzy Inference model integrated with a Model-free Reinforcement Learning model data computing in a healthcare IoT data analytics environment. The simulation results of the SF-MRLDC method show that it is computationally efficient in terms of latency by ensuring better response time.
The shape of you: do people match a specific geometric figure with identity?
Authors: Manippa Valerio , Tommasi Luca 
Published: April 2021

Abstract
Since more than a century, psychologists have been interested in how visual information can arouse emotion. Several studies have shown that rounded figures evoke positive feelings due to their link with happy/baby-like expressions, compared with sharp angular figures, usually associated with anger and threatening objects having negative valence. However, to date, no-one has investigated the preference to associate a simple geometrical shape to one’s own identity, to a close and positive person like the best friend, or to a potentially dangerous one as a stranger. Through 2 online surveys we asked participants to associate a geometric shape, chosen among a circle, a square and a triangle, to each of three identities, namely “you” (the self), “a friend” or “a stranger”. We hypothesized that the circle would be more associated with the self, the square with the friend and the triangle with the stranger. Moreover, we investigated whether these associations are modulated by 3 personality traits: aggressivity, empathy and social fear. How predicted, we found that participants associate more often the circle with the self, the circle and the square with the best friend, whereas matched the angular shapes (both the triangle and the square) to the stranger. On the other hand, the possibility that personality traits can modulate such associations was not confirmed. The study of how people associate geometrical figures with the self or with other identities giving them an implicit socio-affective connotation, is interesting for all the disciplines interested in the automatic affective processes activated by visual stimuli.
Ancient Great Wall Building Materials Reveal Paleoenvironmental Changes in Northwestern China
Authors: Patalano Robert , Hu Jing , Leng Qing , Liu Weiguo , Wang Huanye , Roberts Patrick , Storozum Michael , Yang Lin , Yang Hong 
Published: April 2021

Abstract
Plant material used in the construction of segments and beacon towers of the ancient Great Wall in northwestern China contain untapped potential for revealing paleoenvironmental conditions. Here, we characterize the molecular preservation and stable carbon and nitrogen isotope compositions of common reeds (Phragmites) collected from Great Wall fascines dated to the Han Dynasty in today’s Gansu and Xinjiang provinces using a combination of chromatographic techniques and isotope analyses. Our data demonstrates that ancient reeds were harvested from local habitats that were more diverse than exist today. The isotope data also capture differential rates of environmental deterioration along the eastern margin of the Tarim Basin, leading to the intense evaporative stress on modern plants. This study demonstrates the wealth of environmental and climate information obtainable from site-specific organic building material of ancient walls, which have received considerably less attention than the iconic brick and stone masonry walls of the later Ming Dynasty.
Intrathoracic Fracture-dislocation of the Humeral Head:A Case Report and Review of the Literature
Authors: Yang Ruifeng , wang chong 
Published: April 2021

Abstract
BackgroundIntrathoracic displacement of a humeral head fracture is extremely rare.Only slightly more than 30 cases have been reported. Because few cases have been reported, there is no consensus on how to treat this injury. The etiology, injury mechanism, related lesions and treatment of the injury are diverse.Case presentationA 73-year-old woman presented with multiple fractures of the left ribs, bilateral lung contusions, extensive emphysema of the anterior and posterior chest wall, massive left hemopneumothorax, fracture-dislocation of the proximal humerus and intrathoracic displacement of the humeral head.The patient was sent to the operating room for emergency thoracotomy surgery. The head of the humerus was confirmed to be completely removed from the thoracic cavity during the operation. After discussion with the orthopedic surgeon, the humeral head was discarded considering avascular necrosis, and open reduction and internal fixation were not performed.Three weeks later, the orthopedic surgery team performed reverse shoulder arthroplasty.During follow-up, the patient’s shoulder was free from pain, and its range of movement (ROM) included 110° flexion, 70° abduction, 35° external rotation and 50° internal rotation.Conclusions﻿Intrathoracic displacement of the humeral head due to proximal humeral fracture is a very rare and serious trauma that requires multidisciplinary treatment. Considering the extremely high risk of humeral head necrosis, actively removing broken bone fragments of the humeral head in the early stage is recommended, and we advocate for shoulder arthroplasty for elderly patients. Detailed preoperative evaluations and individualized operation plans should be made to achieve the best effect.
Reversal of SARS-CoV2 Induced Hypoxia by Nebulized Sodium-Ibuprofen in a Compassionate Use Program
Authors: Salva Oscar , Doreski Pablo Alexis , Giler Celia Sara , Quinodoz Dario Conrado , Guzman Lucia Guadalupe , Munoz Sonia Edith , Carrillo Mariana N , Porta Daniela Josefina , Ambasch German , Coscia Esteban , Diaz Jorge Luis Tambini , Bueno German David , Fandi Jorge Oscar , Maldonado Miriam Angelica , Chiappero Leandro Eugenio Peña , Fournier Fernando , Pérez Hernan Alejandro , Quiroga Mauro Andres , Mercado Javier Agustin Sala , Picco Carlos Alberto Martínez , Argañaras Luis Alberto , Rios Nicolas Martinez , Kalayan Galia I. , Beltramo Dante Miguel , Garcia Nestor H 
Published: April 2021

Abstract
BackgroundSodium-ibuprofenate in hypertonic saline (NaIHS) administered directly to the lungs by nebulization and inhalation has antibacterial and anti-inflammatory effects with the potential to deliver these benefits to hypoxic patients. We describe a compassionate use program that offered this therapy to hospitalized COVID-19 patients.MethodsNaIHS (50 mg ibuprofen, tid) was provided in addition to standard of care to hospitalized Covid-19 patients until oxygen saturation levels of >94% were achieved on ambient air. Patients wore a containment hood to diminish aerosolization. Outcome data from participating patients treated at multiple hospitals in Argentina between April 04, 2020, through October 31, 2020 are summarized.Results383 patients were treated, including 327 not on mechanical ventilation at baseline (MV) and 56 ICU patients receiving MV. For those not on baseline MV (59±0.8 years), 64% were male, most with at least one recognized risk factor for disease severity, and mean NEWS2 score prior to treatment initiation of 7.0±0.1. The average length of stay (ALOS) was 11.5±0.3 days and length of treatment (LOT) 9.0±0.2 days. In patients on baseline MV (60.6±2.2 years), 69.9% were male, baseline mean NEWS2 Score was 8.8±0.4, ALOS 15.5±1.4 days and LOT 10.5±0.7 days. Reversal of deterioration in oxygenation and NEWS2 scores was observed acutely following initiation of therapy. Overall in-hospital mortality was 10.7% among patients not on MV at baseline, and 19.6% among patients receiving MV at baseline. No serious adverse events were considered related to ibuprofen therapy.ConclusionsTreatment of COVID-19 pneumonitis with inhalational nebulized NaIHS was associated with rapid improvement in hypoxia and vital signs, with no serious adverse events attributed to therapy. Nebulized NaIHS is worthy of further study in randomized, placebo-controlled trials.(ClinicalTrials.gov:NCT04382768).
Perspectives on Interpersonal Care Among People Who Obtain Abortions Through Clinical and Accompaniment Models in Argentina
Authors: Bercu Chiara , Fillipa Sofia , Ramirez Ana Maria , Katz Anna , Zurbriggen) Colectiva Feminista La Revuelta (Belén Grosso Ruth , Vázquez Sandra , Baum Sarah E. 
Published: April 2021

Abstract
Introduction:

Little is known about how people who obtain abortion services perceive quality and what aspects of interpersonal care matter to them. This qualitative study aimed to understand preferences among people seeking abortions at a reproductive health clinic and an accompaniment model of self-managed abortion in Argentina.
Study Design:

We conducted 24 in-depth interviews with people who obtained abortion care in Neuquén and Buenos Aires, Argentina. We iteratively coded transcripts using a thematic analysis approach based on interpersonal domains present in current quality of care frameworks.
Results

Participants described high-quality abortion care as feeling acompañamiento and contención from their providers – terms that imply receiving kind, caring, compassionate and emotionally supportive care throughout their abortions. They described four key elements of interpersonal interactions: attentive communication from providers and accompaniers, clear and understandable information provision, non-judgmental support, and individualized options for pain management.
Conclusions

People obtaining abortions in two distinct models of care in Argentina consistently identified receiving compassionate and supportive care throughout an abortion as a key aspect of care. The findings have implications for incorporating client perspectives in the development of care guidelines, training of providers, and monitoring and improving of services. This is particularly important as the government of Argentina prepares to expand legal access to abortion.
Alginate Hydrogels as Injectable Drug Delivery Vehicles for Optic Neuropathy Treatment
Authors: Maxwell Courtney J. , Soltisz Andrew M. , Rich Wade W. , Choi Andrew , Reilly Matthew A. , Swindle-Reilly Katelyn 
Published: April 2021

Abstract
Optic neuropathy is the loss of visual acuity following damage to the optic nerve (ON). Traumatic optic neuropathy (TON) occurs when the optic nerve is injured following blunt or penetrating trauma to either the head or eye. Current management options for TON include the systemic delivery of corticosteroids and surgical decompression of the optic nerve; however, neither option alleviates the generation of reactive oxygen species (ROS) which are responsible for downstream damage to the ON. Addressing this limitation, an injectable alginate hydrogel system was developed to act as a drug delivery vehicle for methylene blue (MB), a confirmed ROS scavenger and neuroprotective agent. This MB-loaded polymeric scaffold has the ability to be injected as a liquid and rapidly form a gel around the optic nerve following the primary injury, allowing for the prolonged release of MB. The MB-loaded alginate hydrogels demonstrated minimal cytotoxicity to human retinal pigment epithelial (ARPE-19) cells and facilitated gradual MB release over 12 days. Additionally, the MB concentrations displayed a high degree of ROS scavenging after release from the alginate hydrogels, suggesting our approach may be successful in reducing ROS levels following ON injury.
Ecological succession of fungal and bacterial communities in Antarctic mosses affected by a fairy ring disease
Authors: Rosa Luiz Henrique , Pinto Otávio Henrique Bezerra , Coelho Lívia Costa , Convey Peter , Carvalho-Silva Micheline , Rosa Carlos Augusto , Câmara Paulo EAS 
Published: April 2021

Abstract
We evaluated fungal and bacterial diversity in an established moss carpet on King George Island, Antarctica, affected by ‘fairy ring’ disease using metabarcoding. These microbial communities were assessed through the main stages of the disease. A total of 127 fungal and 706 bacterial taxa were assigned. The phylum Ascomycota dominated the fungal assemblages, followed by Basidiomycota, Rozellomycota, Chytridiomycota, Mortierellomycota and Monoblepharomycota. The fungal community displayed high indices of diversity, richness and dominance, which increased from healthy through infected to dead moss samples. Bacterial diversity and richness were greatest in healthy moss and least within the infected fairy ring. Chalara sp. 1, Alpinaria sp., Helotiaceae sp. 2, Chaetothyriales sp. 1, Ascomycota sp. 1, Rozellomycota sp. and Fungi sp. were most abundant within the fairy ring samples. A range of fungal taxa were more abundant in dead rather than healthy or fairy ring moss samples. The dominant prokaryotic phyla were Actinobacteriota, Proteobacteria, Bacteroidota and Cyanobacteria. The taxon Cyanobacteriia sp., whilst consistently dominant, were less abundant in fairy ring samples. Microbacteriaceae sp. and Chloroflexi sp. were the most abundant taxa within the fairy rings. Our data confirmed the presence and abundance of a range of plant pathogenic fungi, supporting the hypothesis that the disease is linked with multiple fungal taxas. Further studies are required to characterise the interactions between plant pathogenic fungi and their host Antarctic mosses. Monitoring the dynamics of mutualist, phytopathogenic and decomposer microorganisms associated with moss carpets may provide bioindicators of moss health.
Simulation of the Thermoforming Process of Glass Fiber Reinforced Polymeric Components: Investigation of the Combined Effect of the Crosshead Speed and Material Temperature
Authors: Stamopoulos Antonios , Ilio Antoniomaria Di , Genova Luca Glauco Di 
Published: April 2021

Abstract
Thermoplastic based composite materials are increasingly gaining the interest of many engineering sectors, among them the automotive. Their unique features, resulted by the thermoplastic matrix characteristics, such as their recyclability and their formability have given new perspectives in their use. Among the most promising fabrication methods of thermoplastic composite components is the thermoforming process, the press forming of a heated semi-finalized composite plate. This method, although requires a quite simple working station and can be implemented in mass production, demonstrates a series of disadvantages on the quality of the product. Among them, the variation of the thickness, formation of wrinkles and overall undesired deformations are considered as defects that decrease the quality not only from the esthetical but also from the structural point of view. In the present work, a numerical analysis of the thermoforming process is conducted when applied to a box-shaped geometry. As an input for the material behavior during the process, mechanical tests are conducted at elevated temperatures. The flat and curved critical zones of the component are identified and an analysis of the effect of the temperature and the crosshead speed of the molds on the thickness distribution are examined as well as the overall residual stress field. The results indicate a strong dependency of the quality of the product by these parameters of the process.
Adult Patients’ Experience of Coercion in Intensive Care: A Scoping Review
Authors: Jöbges Susanne , Mouton-Dorey Corine , Ricou Bara , Biller-Andorno Nikola 
Published: April 2021

Abstract
Background The use of coercion, which can be understood in a clinical context as imposing a measure against a patient’s opposition or declared will, can occur in various forms in intensive care units (ICU). One prime example of a coercive measure in the ICU is the use of restraints, which are applied for patients` own safety and for the protection of caregivers. A scoping review was conducted to explore the empirical data available on the experiences of ICU patients with coercive measures.Main text For this scoping review, clinical databases (PubMED, EMBASE, PsychINFO, Web of Science Core Collection, CINAHL, Scopus and Cochrane Library) were searched for qualitative studies. Using the CASP criteria for qualitative studies, the review focused on empirical research that captured how ICU patients themselves experienced restraints or other forms of coercion and excluded research related to staff experiences. A total of nine studies could be retrieved that fulfilled the inclusion criteria.The review describes common themes emerging from the scarce studies on patient experiences, including communication issues, delirium, memory, and emotional reactions. In spite of their serious clinical condition and fluctuating states of consciousness, a part of the patients did have memories of their ICU stay. Statements from patients revealed feelings of compromised autonomy and dignity that came with a loss of control. Physical restraints were only one concrete manifestation of coercion as perceived by patients in the ICU setting. Conclusion To date, there are few qualitative studies focusing on patient experiences of coercive measures in the ICU. In addition to the experience of restricted physical movement, the perception of loss of control, loss of dignity and loss of autonomy suggests that restraining measures are just one element in a setting that may be perceived as coercive. Health professionals may underestimate how deeply patients are affected by the perception of coercion. Good communication that clearly explains unavoidable measures to patients can reduce the negative impacts of coercive measures. More research on patient experiences is needed in order to reach a more comprehensive understanding of how patients perceive their ICU stay and to identify opportunities for further improvement of intensive care.