bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategi Peningkatan Kualitas Air Sungai: Studi Kasus Sungai Sani
Authors: Mailisa Evta Rina , Warsito Budi , Yulianto Bambang 
Published: December 2021

ENGLISHApart from supporting irrigation systems, The Sani River has become a source of raw water for a water treatment company called PDAM Tirta Bening to provide clean water to the community. The purpose of this study was to investigate the water quality of the Sani River and formulate priority strategies for improving water quality according to the conditions of the Sani River. This research uses the descriptive-analytic method. Data were obtained from the document of Pati Regency Environmental Service, interviews, field observations, and questionnaires. To determine water quality, this study compared the test result with the water quality standards. Meanwhile, Analytic Hierarchy Process (AHP) became a tool to formulate strategic priorities. The result was TSS in the downstream, BOD, COD, and total phosphate from upstream to downstream, fecal coliform in the middle and downstream, and total coliform in the downstream conditions have exceeded water quality standard. The concentration of Dissolved Oxygen from upstream to downstream was <4 mg/L so it did not comply with the standard. The alternative strategies to improve included increasing community participation, increasing collaboration among stakeholders, supervision and law enforcement, environmental quality monitoring, and river normalization. INDONESIASungai Sani berfungsi dalam irigasi dan sumber air baku untuk PDAM Tirta Bening. Sungai ini termasuk sungai prioritas yang digunakan dalam perhitungan Indeks Kualitas Air Kabupaten Pati. Tujuan dari penelitian ini adalah untuk mengetahui kualitas air Sungai Sani dan merumuskan prioritas strategi peningkatan kualitas air yang sesuai dengan kondisi Sungai Sani. Penelitian ini menggunakan metode deskriptif analitik. Data dalam penelitian ini diperoleh dari dokumen hasil uji Dinas Lingkungan Hidup Kabupaten Pati, hasil wawancara, observasi lapangan, dan pengisian kuesioner. Metode analisis data untuk mengetahui kualitas air adalah dengan membandingkan data hasil uji dengan baku mutu air. Dalam merumuskan prioritas strategi, menggunakan Analytic Hierarchy Process (AHP). Hasilnya adalah TSS di bagian hilir, BOD, COD, dan total fosfat dari hulu sampai ke hilir, fecal coliform di bagian tengah dan hilir, serta total coliform di bagian hilir kondisinya telah melebihi baku mutu air kelas II. Untuk DO, dari hulu sampai hilir konsentrasinya <4 mg/L sehingga tidak mencapai baku mutu air kelas II. Hasil analisis alternatif strategi peningkatan kualitas air Sungai Sani sesuai urutan adalah peningkatan peran serta masyarakat, peningkatan kerja sama antar stakeholder, pengawasan dan penegakan hukum, pemantauan kualitas lingkungan, dan normalisasi sungai.
Penggunaan Salam Smart dalam Meningkatkan Kesehatan Mental dan Penerapan Protokol Kesehatan pada Kelompok Pengajian
Authors: Andayani Tri Rejeki , Wiboworini Budiyanti , Wiyono Nanang , Hidayati Farida 
Published: December 2021

ENGLISHThe covid-19 pandemic that has occurred for a long time brings changes in the entire order of human life, including religion. Religious and social activities, like "pengajian" must immediately adapt to the new norms. An educational program is needed to ensure that every activity in "pengajian" group complies with the health protocols and reduces the potential for the emergence of new Covid-19 clusters. "Salam Smart" Program is a Healthy and Happy Life Strategy in the pandemic period. It is hoped to increase the implementation of health protocols and mental health of the members of this community. This study aimed to describe the contribution of “Salam Smart” Program on mental health improvement and the implementation of health protocols in the "pengajian" group. There were 29 participants to determine the effectiveness of the program. Data were collected using the Prokesmen Scale consisting of subscales i.e. the Health Protocol Scale (Reliability 0.875), and the Mental Health Scale (Rel = 0.796). The descriptive quantitative data analysis was applied and resulted that there was an increase of 2.62 in the application of health care and 3.92 in mental health. It can be concluded that the “Salam Smart” Education Program can be carried on as a strategy to live a healthy and happy life during the pandemic. INDONESIAPandemi Covid-19 yang cukup panjang tentunya membawa perubahan pada seluruh tatanan kehidupan manusia, termasuk agama. Kegiatan keagamaan dan sosial harus segera beradaptasi dengan norma-norma baru. Untuk memastikan setiap kegiatan sesuai dengan protokol kesehatan dan mengurangi potensi munculnya klaster Covid-19 baru dari kelompok pengajian, perlu diadakan program edukasi. Melalui Program “Salam Cerdas” sebagai Strategi Hidup Sehat dan Bahagia di Masa Pandemi. Program ini diharapkan dapat meningkatkan penerapan protokol kesehatan dan kesehatan jiwa para anggota komunitas pengajian. Ada 29 peserta untuk menentukan efektivitas program. Pengumpulan data menggunakan Skala Prokesmen yang terdiri dari subskala yaitu Skala Protokol Kesehatan (Reliabilitas 0,875), dan Skala Kesehatan Jiwa (Rel = 0,796). Analisis data deskriptif kuantitatif digunakan dan hasilnya menunjukkan bahwa ada peningkatan 2,62 dalam penerapan perawatan kesehatan dan 3,92 dalam kesehatan mental. Dapat disimpulkan bahwa Program Pendidikan “Salam Cerdas” dapat dijadikan sebagai strategi untuk hidup sehat dan bahagia di masa pandemi.
Genetic Clues on Implantable Cardioverter-Defibrillator Placement in Young-Age Hypertrophic Cardiomyopathy: A Case Report of Novel MYH7 Mutation and Literature Review
Authors: Li Xing , Tang Jie , Li Jinhui , Lin Sha , Wang Tao , Zhou Kaiyu , Li Yifei , Hua Yimin 
Published: December 2021

Background: Hypertrophic cardiomyopathy (HCM) is the second most common cardiomyopathy in childhood with a life-threatening risk. Implantable cardioverter-defibrillator (ICD) placement is recommended for early prevention if there are two or more clinical risk factors. Pediatric patients with HCM are at a higher risk of sudden cardiac death (SCD), but there are limited reports on indications for ICD implantation in children. Herein we describe the case of Myh7 mutation-induced HCM and cardiac arrest in a patient and evaluated information originating from genetic background to guide ICD administration.Case Presentation: The patient was a girl aged 7 years and 8 months who had been diagnosed with cardiomyopathy in utero 8 years prior. She had had recurrent cardiac arrests within the last 4 years. Electrocardiography indicated abnormalities in conduction, and ST segment changes. Echocardiography indicated significant left ventricular hypertrophy and hypertrophic systolic interventricular septum. Cardiac magnetic resonance imaging depicted general heart enlargement with hypertrophy, and delayed enhancement in myocardium with perfusion defect was also evident. Whole exon sequencing identified a de novo c.2723T&gt;C (p.L908P) heterozygous mutation in the MYH7 gene. MYH7 p.L908P predicted unstable protein structure and impaired function. The patient was scheduled for ICD implantation. There were no complications after ICD implantation, and she was discharged from hospital on the 10th day. Regular oral beta-blockers, amiodarone, spironolactone, and enalapril were administered, and she was required to attend hospital regularly for follow-up. During follow-up there were no cardiac arrests. Literature review of clinical prognoses associated with genetic mutations of MYH7, MYBPC3, TNNI3, TNNT2, and TPM1 in pediatric HCM patients with and without ICD implantation indicated that they were totally differently. Previous reports also indicated that gene mutations predicted earlier onset of cardiac hypertrophy, and increase likelihood of SCD.Conclusion: Variant burden and variant type contribute to the risk of adverse events in pediatric HCM. Early recognition and intervention are vital in children. Gene mutation could be considered an indication for early ICD placement during standard risk stratification of HCM patients. Whether this extends to the majority of pediatric patients requires further investigation.
Evaluation of Various DEMs for Quantifying Soil Erosion Under Changing Land Use and Land Cover in the Himalaya
Authors: Romshoo Shakil Ahmad , Yousuf Aazim , Altaf Sadaff , Amin Muzamil 
Published: December 2021

Soil erosion is one of the serious environmental threats in the Himalayas, primarily exacerbated by the steep slopes, active tectonics, deforestation, and land system changes. The Revised Universal Soil Loss Equation was employed to quantify soil erosion from the Vishav watershed in the Kashmir Himalaya, India. Topography and land use/land cover (LULC) are important driving factors for soil erosion. Most often, a Digital Elevation Model (DEM) is used in erosion models without any evaluation and testing which sometimes leads to erroneous estimates of soil erosion. For the best topographic characterization of the watershed, four publicly available DEMs with almost identical resolution (∼30 m), were evaluated. The DEMs were compared with GPS measurements to determine the most reliable among the tested DEMs for soil erosion estimation. Statistical evaluation of the DEMs with GPS data indicated that the CARTO DEM is better with root mean square error (RMSE) of 18.2 m than the other three tested DEMs viz., Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER), Shuttle Radar Topography Mission (SRTM), and Advanced Land Observing Satellite (ALOS). Slope length and slope steepness factors were computed from the DEMs. Crop cover and management factors were generated from the satellite-derived LULC. Moreover, rainfall data of the nearest stations were used to compute rainfall erosivity and soil erodibility factor was derived from the soil texture data generated from 375 soil samples. The simulated erosion estimates from SRTM, ALOS, and CARTO DEMs showed similar spatial patterns contrary to the ASTER estimates which showed somewhat different patterns and magnitude. The mean erosion in the study area has almost doubled from 2.3 × 106 tons in 1981 to 4.6 × 106 tons in 2019 mainly driven by the anthropogenic LULC changes. The increased soil erosion is due to the degradation of forest cover, urbanization, steep slopes, and land system changes observed during the period. In absence of the observations, the simulated soil erosion was validated with the land degradation map of the watershed which showed a good correspondence. It is hoped that the results from this work would inform policymaking on soil and water conservation measures in the data-scarce mountainous Kashmir Himalaya.
Safety and Efficacy of an Atraumatic Uterine Cervical Traction Device: A Pilot Study
Authors: Legardeur Hélène , Masiello-Fonjallaz Gessica , Jacot-Guillarmod Martine , Mathevet Patrice 
Published: December 2021

Introduction: Alignment of the uterine cervix with the vaginal canal is often required during insertion of an intrauterine contraceptive device (IUD). Currently available instruments are traumatic tenacula, which can cause pain and bleeding and represent an obstacle for certain patients to pursue their medical follow-up. A novel investigational cervical vacuum tenaculum, enables atraumatic traction of the cervix using a semi-circular suction pad, designed to conform to the anatomical shape of the external cervical os. Suction is generated by manually pulling out a sliding tube in a vacuum chamber.Methods: We performed a single arm non-comparative pilot study to assess the safety and efficacy of the cervical vacuum tenaculum in 13 women receiving an IUD. Data on procedural efficacy, safety, patient-reported pain scores at specific time points during IUD insertion procedure and patient satisfaction were collected prospectively.Results: Insertion of IUD was successful with use of the study device in 7 of the 13 enrolled patients (54%). No bleeding or only limited ecchymosis were caused by the device. No adverse events were reported. Participants reported very little pain (mean Visual Analog Scale &lt;10) when applying the device. Participants who achieved IUD insertion with the device reported strong overall satisfaction with the procedure.Conclusions: The suction-based atraumatic tenaculum can be used to manipulate the cervix during IUD insertion with satisfactory efficacy and safety. The results of this pilot study support further studies of this device in larger populations comparing with standard single-tooth tenaculum.Clinical Trial Registration:ClinicalTrials.gov, identifier: NCT 04441333.
Ameliorating Metabolic Profiles After Kidney Transplantation: A Protocol for an Open-Label, Prospective, Randomized, 3-Arm, Controlled Trial
Authors: Yin Saifu , Ma Ming , Huang Zhongli , Fan Yu , Wang Xianding , Song Turun , Lin Tao 
Published: December 2021

Aim: High prevalence of metabolic disorders causes higher risk of cardiovascular diseases after kidney transplantation (KT), which remains the main burden impairing short-term and long-term survival. This open-label, prospective, randomized, 3-arm, controlled trial will evaluate the safety, tolerability and efficacy of metformin and empagliflozin in ameliorating metabolic profiles after KT.Methods: After a screening assessment, eligible patients with an estimated glomerular filtration rate (eGFR) &gt;45 mL/min/1.73m2 are randomly assigned to standard triple immunosuppression alone, standard immunosuppression plus metformin (500 mg twice daily), standard immunosuppression plus empagliflozin (25 mg once daily) from discharge. The primary endpoint is the differences in the visceral-to-subcutaneous fat area ratio over 12 months, evaluated by magnetic resonance imaging (MRI). Secondary outcomes include kidney graft function, glycometabolism, lipid metabolism, and inflammatory parameters. The trial will enroll 105 kidney transplant recipients, providing 90% power to detect the difference at 5% significance.
Relationship Between Patient Sex and Serum Tumor Necrosis Factor Antagonist Drug and Anti-drug Antibody Concentrations in Inflammatory Bowel Disease; A Nationwide Cohort Study
Authors: Shehab Mohammad , Alasfour Hajer , Abdullah Israa , Alhendi Ghadeer , Alhadab Anwar , Alfadhli Ahmad , Ziyab Ali H. , Battat Robert 
Published: December 2021

Background: Anti-drug antibodies to infliximab (ATI) and adalimumab (ATA) are associated with loss of response to tumor necrosis factor antagonist (anti-TNF) therapy in inflammatory bowel disease (IBD). We evaluated the relationship between patient sex and serum TNF antagonist drug and antibody concentrations in inflammatory bowel disease.Methods: A nationwide multicenter retrospective cohort study was conducted by evaluating patients' charts from July 2018 until September 2021. The effect of patient sex on anti-drug antibodies and serum drug concentration in patients with IBD across seven hospitals was investigated. A subgroup analysis also investigated the effect of anti-TNF combination therapy. Geometric means were calculated, and multiple linear regression was used to estimate the adjusted ratio of geometric means (RoGM) and their 95% confidence intervals (CI).Results: In the total study sample (n = 1093), males receiving infliximab had higher anti-drug antibody concentrations (38.3 vs. 22.3 AU/ml; aRoGM = 1.72, 95% CI: 1.30–2.27, p &lt; 0.001) compared to females. Additionally, infliximab serum drug concentrations among males were lower compared to females (2.6 vs. 4.1 ug/ml; aRoGM = 0.62, 95% CI: 0.44–0.88, p = 0.007). In the subgroup analysis (n = 359), male compared to female patients on combination therapy with infliximab and immunomodulators had similar anti-drug antibody concentrations (30.2 vs. 21.9 AU/ml; aRoGM = 1.38, 95% CI: 0.79–2.40, p = 0.254). There was no difference in the anti-drug antibody and serum drug concentrations among males and females on adalimumab.Conclusion: In patients receiving infliximab, anti-drug antibodies were higher in males than females. Consistent with this, serum drug concentrations were lower in males than females on infliximab. There was no difference in anti-drug antibody and serum drug concentrations among males and females on adalimumab. In addition, no difference in anti-drug antibodies between males and females receiving anti-TNF combination therapy was observed.
HomeCoRe for Telerehabilitation in Mild or Major Neurocognitive Disorders: A Study Protocol for a Randomized Controlled Trial
Authors: Bernini Sara , Panzarasa Silvia , Sinforiani Elena , Quaglini Silvana , Cappa Stefano F. , Cerami Chiara , Tassorelli Cristina , Vecchi Tomaso , Bottiroli Sara 
Published: December 2021

Background: Given the limited effectiveness of pharmacological treatments for cognitive decline, non-pharmacological interventions have gained increasing attention. Evidence exists on the effectiveness of cognitive rehabilitation in preventing elderly subjects at risk of cognitive decline and in reducing the progression of functional disability in cognitively impaired individuals. In recent years, telerehabilitation has enabled a broader application of cognitive rehabilitation programs. The purpose of this study is to test a computer-based intervention administered according to two different modalities (at the hospital and at home) using the tools CoRe and HomeCoRe, respectively, in participants with Mild or Major Neurocognitive Disorders.Methods: Non-inferiority, single-blind randomized controlled trial where 40 participants with Mild or Major Neurocognitive Disorders will be assigned to the intervention group who will receive cognitive telerehabilitation through HomeCoRe or to the control group who will receive in-person cognitive intervention through CoRe, with the therapist administering the same computer-based exercises. The rehabilitative program will last 6 weeks, with 3 sessions/week, each lasting ~45 min. All the participants will be evaluated on an exhaustive neuropsychological battery before (T0) and after (T1) the intervention; follow-up visits will be scheduled after 6 (T2) and 12 months (T3).Discussion: The results of this study will inform about the comparability (non-inferiority trial) of HomeCoRe with CoRe. Their equivalence would support the use of HomeCoRe for at distance treatment, favoring the continuity of care.Ethics and Dissemination: This study has been approved by the Local Ethics Committee and registered in https://clinicaltrials.gov (NCT04889560). The dissemination plan includes the scientific community through publication in open-access peer-reviewed scientific journals and presentations at national and international conferences.Trial Registration:Clinicaltrials.govhttps://clinicaltrials.gov/ct2/show/NCT04889560 (registration date: May 17, 2021).
Trends in Development of Novel Machine Learning Methods for the Identification of Gliomas in Datasets That Include Non-Glioma Images: A Systematic Review
Authors: Subramanian Harry , Dey Rahul , Brim Waverly Rose , Tillmanns Niklas , Cassinelli Petersen Gabriel , Brackett Alexandria , Mahajan Amit , Johnson Michele , Malhotra Ajay , Aboian Mariam 
Published: December 2021

PurposeMachine learning has been applied to the diagnostic imaging of gliomas to augment classification, prognostication, segmentation, and treatment planning. A systematic literature review was performed to identify how machine learning has been applied to identify gliomas in datasets which include non-glioma images thereby simulating normal clinical practice.Materials and MethodsFour databases were searched by a medical librarian and confirmed by a second librarian for all articles published prior to February 1, 2021: Ovid Embase, Ovid MEDLINE, Cochrane trials (CENTRAL), and Web of Science-Core Collection. The search strategy included both keywords and controlled vocabulary combining the terms for: artificial intelligence, machine learning, deep learning, radiomics, magnetic resonance imaging, glioma, as well as related terms. The review was conducted in stepwise fashion with abstract screening, full text screening, and data extraction. Quality of reporting was assessed using TRIPOD criteria.ResultsA total of 11,727 candidate articles were identified, of which 12 articles were included in the final analysis. Studies investigated the differentiation of normal from abnormal images in datasets which include gliomas (7 articles) and the differentiation of glioma images from non-glioma or normal images (5 articles). Single institution datasets were most common (5 articles) followed by BRATS (3 articles). The median sample size was 280 patients. Algorithm testing strategies consisted of five-fold cross validation (5 articles), and the use of exclusive sets of images within the same dataset for training and for testing (7 articles). Neural networks were the most common type of algorithm (10 articles). The accuracy of algorithms ranged from 0.75 to 1.00 (median 0.96, 10 articles). Quality of reporting assessment utilizing TRIPOD criteria yielded a mean individual TRIPOD ratio of 0.50 (standard deviation 0.14, range 0.37 to 0.85).ConclusionSystematic review investigating the identification of gliomas in datasets which include non-glioma images demonstrated multiple limitations hindering the application of these algorithms to clinical practice. These included limited datasets, a lack of generalizable algorithm training and testing strategies, and poor quality of reporting. The development of more robust and heterogeneous datasets is needed for algorithm development. Future studies would benefit from using external datasets for algorithm testing as well as placing increased attention on quality of reporting standards.Systematic Review Registrationwww.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020209938, International Prospective Register of Systematic Reviews (PROSPERO 2020 CRD42020209938).
Surgical Management of Non-Metastatic Pancreatic Cancer in the United Kingdom: Results of a Nationwide Survey on Current Practice
Authors: Gemenetzis Georgios , McKay Siobhan , Pathak Samir , Moir John , Laing Richard , Jamieson Nigel B. , Young Alastair L. , Chatzizacharias Nikolaos A. , Giovinazzo Francesco , Roberts Keith J. 
Published: December 2021

BackgroundIt is presently unclear what clinical pathways are followed for patients with non-metastatic PDAC in specialised centres for pancreatic surgery across the United Kingdom (UK).MethodsBetween August 2019 and August 2020 an electronic survey was conducted aiming at a national cohort of pancreatic surgeons in the UK. Participants replied to a list of standardised questions and clinical vignettes, and data were collected and analysed focusing on management preferences, resectability criteria, and contraindications to surgery.ResultsWithin the study period, 65 pancreatic surgeons from 27 specialist centres in the UK (96%) completed the survey. Multidisciplinary team meetings are utilised universally for the management of patients with PDAC, however, different staging systems for resectability classification are being applied. In borderline resectable PDAC, most surgeons were keen to proceed with surgical exploration post NAT, but differences were noted in preferred chemotherapy regimens. Surgeons from standard volume institutions performed fewer vein resections annually and were more likely to deem patients with locally advanced PDAC as unresectable. Intra-institutional variability in patient management was also present and ranging between 20-80%.ConclusionsSignificant variability in the surgical management of non-metastatic PDAC was identified both on inter- and intra-institutional level.