bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associated Factors with the Severity of Hip Involvement in Spondyloarthritis and Efficacy of TNF α Inhibitors in these Patients
Authors: Slouma Maroua , Rahmouni Safa , Dhahri Rim , Cheour Elhem , Gharsallah Imen , Metoui Leila , Louzir Bassem 
Published: October 2021

Introduction:
Hip involvement in patients with spondyloarthritis is responsible for disability
and functional impairment. Its treatment is not codified.
Our study aimed to determine the associated factors with moderate and severe hip involvement in
spondyloarthritis patients. It also aimed to assess the efficacy of tumour necrosis factor inhibitors
(TNFi) on hip disease.

Methods:
We conducted a cross-sectional study, including 44 spondyloarthritis patients with hip involvement.
Hip involvement was diagnosed based on radiographic findings. We assessed the following
parameters: Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing
Spondylitis Radiology Index (BASRI), patient global assessment (PGA), and Lequesne index. We
compared these parameters and the mean radiographic joint space width between the time of the
study to those right before the use of TNFi.

Results:
Hip involvement was bilateral in 31 patients. The mean age was 44.56±12.21 years. There
were 29 men. Severe and moderate involvement (BASRI-hip>3) was reported in 21 hips from 75
affected. These patients were older and had longer diagnosis delays than patients with BASRI-
hip<3. They had a higher body mass index and more limited spine mobility (BASMI). Functional
hip impairment assessed by the Lequesne index was higher in these patients.
TNFi prescribed in 23 patients with hip involvement, led to an improvement in the Lequesne index
(12.75 vs 7.5, p: 0.001) and PGA (7 vs 2, p: 0.001). However, the mean joint space width remained
unchanged (3.8 vs 3.7mm, p: 0.532).

Conclusion :
Our study showed that higher body mass and Lequesne indexes are associated with
moderate and severe hip involvement. TNFi may improve both the Lequesne index and PGA and
stabilize the radiological findings.
Sensitivity and Specificity of Mandibular Third Molar Calcification at Chronological Age and Hand Wrist Maturation Stage to Discriminate Between Female and Male at Pubertal Growth Period
Authors: Mardiati Endah , Komara Ira , Halim Himawan , Kurnia Dikdik , Maskoen Ani Melani 
Published: October 2021

Background:
The mandibular third molar is the last tooth that is not completely developed by the time pubertal growth has been finished. Maturation of the mandibular third molar is one of the physiological maturation indicators that can be used to determine the stage of pubertal growth.

Objective:
The aim of the study was to determine the sensitivity and specificity of mandibular third molar calcification at chronological age and hand wrist maturation stage to discriminate between female and male at pubertal growth period.

Methods:
It is a retrospective study with a cross-sectional approach using panoramic and hand-wrist digital radiographs of 279 females and 144 males, age 8-17 years, with a total of 423 panoramic radiographs and 423 hand-wrist radiographs. Statistical analysis was performed using Excel Mega Stat. ANOVA to analyze the differences between mandibular third molar calcification at chronological age and hand-wrist maturation stage, and t-test was used to analyze the differences between females and males. Spearman rank correlation was used for the analysis of the correlation between mandibular third molar calcification with chronological age and hand-wrist maturation stage; sensitivity and specificity were used to discriminate the pubertal growth period between mandibular third molar calcification and hand-wrist maturation stage.

Results:
There were significant differences found in mandibular third molar crown maturation stage B and C, but no significant difference was observed between mandibular third molar stage A, D, E, F, G and H, between females and males. The highest percentage of mandibular third molar crown formation in females was observed at stage D (6.68%) at MP3u, and in males, it was observed at stage D (8.83%) at SMI-4. The highest percentage of root formation in females was stage E (8.24%) at the SMI-10 stage, and males stage F (4.86%) at MP3u. The correlation was observed between mandibular third molar calcification with hand-wrist, females 0.22 and males 0.43, and chronological age 0.60 for females and 0.69 for males. The highest sensitivity of mandibular third molar calcification of 97.0% was observed in female at SMI-4 of hand-wrist maturation with specificity of 100%, while in male, a sensitivity of 94.5% was observed at SMI-2 stage with a specificity of 99.99%.

Conclusion:
There were significant differences found in mandibular third molar calcification between females and males except for stage B and stage C; weak correlation was observed between mandibular third molar calcification and hand-wrist, and moderate correlation was observed with chronological age. The sensitivity and specificity in females and males indicate that mandibular third molar calcification is only useful for diagnosing the pre-pubertal growth phase.
Surface Morphological Changes and Predisposition to Staining in Dental Enamel Bleached with Different Hydrogen Peroxide Concentrations
Authors: Guimarães Douglas Magno , de Paula Brennda Lucy Freitas , Rodrigues Luciane Margalho , Costi Hilton Túlio , Ghislain Rogez Hervé Louis , Silva Cecy Martins 
Published: October 2021

Background:
The tooth bleaching treatment can cause structural changes in the surfaces of the teeth; these changes can increase the absorption of staining agents.

Purpose:
This study assessed surface morphological changes and predisposition to staining in dental enamel bleached with different hydrogen peroxide (HP) concentrations, with or without the use of a light source (LS).

Methods:
25 bovine incisor specimens were divided into five groups (n = 5): Control- no treatment; HP35 - hydrogen peroxide 35%; HP35+LED - hydrogen peroxide 35% + light emission; HP20 - hydrogen peroxide 20%; and HP7 - hydrogen peroxide 7,5%. Twenty days after bleaching, the specimens were immersed in staining solutions four hours a day for 28 days. The morphological alterations of the bovine enamel surface were evaluated by means of scanning electron microscopy, X-ray dispersive energy spectroscopy and predisposition to the staining of the brightened enamel by means of colorimetry.

Results:
ANOVA with Tukey's test (p<0.05) showed that HP7 had the highest ΔL values (p=0.176) (brightest), with a better lightening effect. The bleached groups exhibited morphological changes in the enamel. The groups did not exhibit significant changes in oxygen, calcium, and phosphorus values (p=0.020). The presence or absence of light was not significant (p=0.007) for the predisposition to staining in bleached teeth.

Conclusion:
The time of exposure to the staining solution was significant for staining bovine dental enamel. High concentrations of HP were not necessary for achieving effective bleaching. HP caused an increase in enamel porosity and depressions. The light source did not influence bleaching.
Rehabilitation of Atrophic Posterior Mandible with Vertical Ridge Augmentation with Resorbable Membrane: Case Report with 3-Year Follow-up
Authors: Landázuri Del Barrio Ricardo Andrés , Braga Miziara Luciano Nascimento , Al Houch Alia Oka , Sendyk Wilson Roberto , Roman-Torres Caio Vinicius Gonçalves , Castro Pimentel Angélica , Fonseca Marão Heloisa 
Published: October 2021

Background:
The placement of implants in the posterior mandible with the vertical bone defect can be associated with inadequate crown height space. Therefore, the vertical bone reconstruction of these defects is often necessary, although this procedure is technically challenging.

Methods:
A 49-year-old patient attended a private dental office for rehabilitation of an atrophic posterior mandible. The clinical and tomographic findings show absence of teeth #36, #37, #46, #47, and #48 with severe atrophy. Vertical bone augmentation was performed by using the guided bone regeneration technique with pericardium resorbable membrane followed by placement of short implants. The free gingival graft was performed, and after three months, screw-retained lithium disilicate single ceramic crowns were manufactured.

Results:
After a 3-years follow-up, bone loss around the implants or presence of gingival inflammation was not observed, and the prosthesis adaptation was found to have no alteration either. Therefore, aesthetics, as well as masticatory and speech functions, were preserved.

Conclusion:
There was no bone loss around the implants. The association between vertically guided bone regeneration using pericardium resorbable membrane is an alternative technique, and it avoids complications related to non-resorbable membrane exposure. It was shown to be viable after a 3-year follow-up.
Immunopharmacological Properties of VitD3: 1, 25VitD3 Modulates Regulatory
T Cells and Th17 Cells and the Cytokine Balance in PBMCs from
Women with Unexplained Recurrent Spontaneous Abortion (URSA)
Authors: Gao Jiefan , Wang Li , Bu Lei , Song Yangyang , Huang Xiao , Zhao Jing 
Published: October 2021

Background:
VitD3 may contribute to a successful pregnancy through modulation of
immune responses. Therefore, VitD3 deficiency may have a role in the immunopathogenesis of unexplained
recurrent spontaneous abortion (URSA). However, the mechanisms of immunomodulatory
actions of VitD3 in decreasing the risk of recurrent spontaneous abortion have not been understood
well.

Objective:
The purpose of this research was to investigate the influence of 1,25VitD3 on regulatory
T cells /Th17 axis, the gene expressions and concentrations of related cytokines including, TGF-β,
IL-10, IL-6, IL-23, and IL-17A in peripheral blood mononuclear cells (PBMCs) of healthy women
as a control group and women with URSA.

Method:
Isolation of PBMCs was performed from peripheral blood of the subjects of the studied
groups (20 women with URSA as a case group, and 20 control women). The effects of 1,25VitD3
(50 nM, for 24 hours) on the studied parameters were evaluated and were compared to the positive
and negative controls in vitro. Flow cytometry analysis was used to determine the percentages of
regulatory T cells and Th17 cells. For gene expression measurement and cytokines assay, Realtime
PCR and ELISA were carried out.

Results:
The proportion of regulatory T cells was markedly lower, while the proportion of Th17
cells in women with URSA was considerably higher than in the control group (P=0.01, P=0.01).
The ratio of the frequency of Tregs to the baseline (1,25VitD3/Untreated) increased, while the ratio
of the frequency of Th17 cells to the baseline decreased in women with URSA relative to the controls
(P= 0.01, P=0.04). 1,25VitD3 increased IL-10 expressions at both the protein and mRNA levels
in PBMCs in women with URSA relative to the control group (P=0.0001, P=0.04). TGF-β levels
in the cultured supernatants decreased significantly in the case group in the presence of 1,25Vit-
D3 relative to the controls (P=0.03). 1,25VitD3 treatment also significantly decreased gene expressions
of IL-6, IL-17A, and IL-23 in PBMCs of women with URSA (P=0.01, P=0.001, P=0.0005),
as well as the levels of those cytokines in cell culture supernatants (P=0.03, P=0.02, P=0.01, respectively)
in women with URSA relative to the controls.

Conclusion:
According to the findings of this research, modulation of immune responses by
1,25VitD3 is accomplished by strengthening Tregs function and inhibiting inflammatory responses
of Th17 cells, which may have a positive impact on pregnancy outcome. Thus, as an immunomodulating
agent, VitD3 may be effective in reducing the risk of URSA.
Isocarpine as A New Peperidine Alkaloid from Adenocarpus Complicatus
with Anticandidal Activity
Authors: Alhilal Mohammad , Alhilal Suzan , Gomha Sobhi , Ouf Salama 
Published: October 2021

Background:
Adenocarpus complicatus L. is one of Adenocarpus genus, which has
about 50 species, from Fabaceae (Papilionaceae) family. This plant is found in the Mediterranean
basin as a southern west part of Europe and North Afric forestes

Objective:
Isolation of Isocarpine From Adenocarpus Complicatus as Anticandidal Agent method
A new piperidine alkaloid Isocarpine was isolated from the aerial parts of Adenocarpus complicatus
L., which is gross in Syria. The structure of the new compound was determined by UV, IR, EIMs,
1H-NMR, 13C-NMR, DEPT-135, DQF-COSY and HMQC.

Results:
The anticandidal activity of isocarpine was screened against 38 Candida strains and
showed remarkable inhibitory effect compared with fluconazole as an antifungal reference drug.

Conclusion:
Isocarpine is antifungal agent.
Mnemonic Discrimination in Obsessive Compulsive Disorder Patients: A Case-Control Study
Authors: Aldi Giulia Anna , Mansueto Giovanni , Albert Umberto , Melter Claudia Cumerlato , Maina Giuseppe , Cosci Fiammetta 
Published: October 2021

Background:
Fear generalization is an adaptive mechanism which enables
an individual to appropriately respond to novel stimuli based on overlapping
features with a learned threat stimulus. When it is maladaptive, it is named
overgeneralization. Overgeneralization was observed in psychiatric disorders, including
Obsessive-Compulsive Disorder (OCD). Overgeneralization seems to be
related to mnemonic discrimination, a fundamental component of memory which
encodes a given event as distinct from highly similar events. Mnemonic discrimination
is thought to rely on Pattern Separation (PS), which plays a critical role in
discriminating safe stimuli similar to threatening ones. PS performance showed
to be impaired in patients with some psychiatric disorders but has never been
studied in OCD.

Objective:
Mnemonic discrimination for context, used as a proxy of pattern separation,
was measured in patients with OCD to verify whether it is related to overgeneralization.

Method:
Thirty patients with OCD and 30 non-psychiatric controls were enrolled
(matched for sex, age). The Mnemonic Similarity Task-Object and the
Mnemonic Similarity Task-Contest were administered to assess PS performance.

Results:
When patients with OCD and controls were compared, statistically significant
differences were not found for mnemonic performances and pattern separation.
Based on multivariate regression analysis, the group of patients with OCD
was more likely to report lower mnemonic discrimination for context (OR =
0.67, 95% CI = 0.48-0.93) than the control group.

Conclusion:
Mnemonic discrimination for context was specifically referred to as
new lures misidentified as similar. It is hypothesized that pattern separation performances
might discriminate patients with OCD from non-psychiatric subjects.
Ecological Momentary Assessment of Physical Activity and Wellness Behaviors in College Students Throughout a School Year: Longitudinal Naturalistic Study
Authors: Bai Yang , Copeland William E , Burns Ryan , Nardone Hilary , Devadanam Vinay , Rettew Jeffrey , Hudziak James 
Published: October 2021

Background
The Wellness Environment app study is a longitudinal study focused on promoting health in college students.

Objective
The two aims of this study were (1) to assess physical activity (PA) variation across the days of the week and throughout the academic year and (2) to explore the correlates that were associated with PA, concurrently and longitudinally.

Methods
The participants were asked to report their wellness and risk behaviors on a 14-item daily survey through a smartphone app. Each student was provided an Apple Watch to track their real time PA. Data were collected from 805 college students from Sept 2017 to early May 2018. PA patterns across the days of the week and throughout the academic year were summarized. Concurrent associations of daily steps with wellness or risk behavior were tested in the general linear mixed-effects model. The longitudinal, reciprocal association between daily steps and health or risk behaviors were tested with cross-lagged analysis.

Results
Female college students were significantly more active than male ones. The students were significantly more active during the weekday than weekend. Temporal patterns also revealed that the students were less active during Thanksgiving, winter, and spring breaks. Strong concurrent positive correlations were found between higher PA and self-reported happy mood, 8+ hours of sleep, ≥1 fruit and vegetable consumption, ≥4 bottles of water intake, and ≤2 hours of screen time (P<.001). Similar longitudinal associations found that the previous day’s wellness behaviors independently predicted the following day’s higher PA except for mood. Conversely, the higher previous-day PA levels were associated with better mood, more fruit and vegetable consumption, and playing less music, but with higher liquor consumption the next day.

Conclusions
This study provides a comprehensive surveillance of longitudinal PA patterns and their independent association with a variety of wellness and risk behaviors in college students.
Patient-Reported Outcome Measure for Real-time Symptom Assessment in Women With Endometriosis: Focus Group Study
Authors: van Barneveld Esther , Lim Arianne , van Hanegem Nehalennia , Vork Lisa , Herrewegh Alexandra , van Poll Mikal , Manders Jessica , van Osch Frits , Spaans Wilbert , van Koeveringe Gommert , Vrijens Desiree , Kruimel Joanna , Bongers Marlies , Leue Carsten 
Published: October 2021

Background
Symptoms related to endometriosis have a significant impact on the quality of life, and symptoms often recur. The experience sampling method (ESM), a digital questioning method characterized by randomly repeated momentary assessments, has several advantages over traditionally used measurements, including the ability to assess the temporal relationship between variables such as physical, mental, and social factors.

Objective
The aim of this study is to develop an ESM tool for patients with endometriosis to accurately measure symptoms and their course over time, allowing for personalized treatment and adequate monitoring of treatment efficacy in individual patients.

Methods
On the basis of international guidelines, items from validated questionnaires were selected through a literature review and during focus groups and multidisciplinary expert meetings. Data analysis was conducted using ATLAS.ti (ATLAS.ti Scientific Software Development GmbH). The feasibility and usability of the newly developed momentary assessment tool were tested for 28 consecutive days in 5 patients with endometriosis-related pain symptoms.

Results
Momentary assessment items contained questions concerning endometriosis symptoms, general somatic symptoms, psychological symptoms, contextual information, and the use of food and medication. A morning questionnaire on sleep and sexuality was included. In a pilot study, the patients considered the tool easy to use but time consuming. The average compliance rate of momentary assessments was 37.8% (106/280), with the highest completion rate during the first week (39/70, 56%). Therefore, it is advisable to use the ESM for a maximum of 7 days.

Conclusions
A new digital tool for endometriosis symptom assessment was developed using the ESM, which may help overcome the limitations of current retrospective questionnaires. After validation and testing, future studies will be planned to evaluate the use of this tool in a clinical setting in order to propose a personalized treatment plan for women with endometriosis.
Role of Telemedicine in Inflammatory Bowel Disease: Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Pang Lanlan , Liu Hengyu , Liu Zhidong , Tan Jinyu , Zhou Long-yuan , Qiu Yun , Lin Xiaoqing , He Jinshen , Li Xuehua , Lin Sinan , Ghosh Subrata , Mao Ren , Chen Minhu 
Published: October 2021

Background
Telemedicine plays an important role in the management of inflammatory bowel disease (IBD), particularly during a pandemic such as COVID-19. However, the effectiveness and efficiency of telemedicine in managing IBD are unclear.

Objective
This systematic review and meta-analysis aimed to compare the impact of telemedicine with that of standard care on the management of IBD.

Methods
We systematically searched the PubMed, Cochrane Library, EMBASE, Web of Science, and Scopus databases on April 22, 2020. Randomized controlled trials comparing telemedicine with standard care in patients with IBD were included, while conference abstracts, letters, reviews, laboratory studies, and case reports were excluded. The IBD-specific quality of life (QoL), disease activity, and remission rate in patients with IBD were assessed as primary outcomes, and the number of in-person clinic visits per patient, patient satisfaction, psychological outcome, and medication adherence were assessed as secondary outcomes. Review Manage 5.3 and Stata 15.1 were used for data analysis.

Results
A total of 17 randomized controlled trials (2571 participants) were included in this meta-analysis. The telemedicine group had higher IBD-specific QoL than the standard care group (standard mean difference 0.18, 95% CI 0.01 to 0.34; P.03). The number of clinic visits per patient in the telemedicine group was significantly lower than that in the standard care group (standard mean difference −0.71, 95% CI −1.07 to −0.36; P<.001). Subgroup analysis showed that adolescents in the telemedicine group had significantly higher IBD-specific QoL than those in the standard care group (standard mean difference 0.42, 95% CI 0.15 to 0.69; I2=0; P.002), but there was no significant difference between adults in the 2 groups. There were no significant differences in disease activity, remission rate, patient satisfaction, depression, self-efficacy, generic QoL, and medication adherence outcomes between the telemedicine and standard care groups.

Conclusions
Telemedicine intervention showed a promising role in improving IBD-specific QoL among adolescents and decreased the number of clinic visits among patients with IBD. Further research is warranted to identify the group of patients with IBD who would most benefit from telemedicine.
Estimation of the efficiency of measures of correction of the functional state of the cardiovascular system of operators of deep water technical means during the course of the voyage
Authors: Khankevich Yu. R. , Sapozhnikov K. V. , Cherkashin D. V. , Kutelev G. G. , Parfenov S. A. , Paulov A. A. 
Published: October 2021

During the course of the voyage, divers experience the effect of the wide range of adverse factors of operator labor and ship's habitability.The objective of the study is to estimate the state of cardiovascular system of operators of deep water technical means after using the complex of measures aimed at correction of function al state of operators during the course of the voyage.Materials and methods. The study was conducted with the participation of 38 operators of deep water technical means from among the crew of nuclear submarine engaged in operator labor activity. The study was performed twice: before the voyage and after return to base and included: cardiorhythmogram and psychophysiological study methodologies of functional state. Patients were divided into two groups: main (n = 13) and control (n = 25).Results and discussion. The control group shows sympathicotonia (reducing heart rate variability, intensity of respiratory arrhythmia). The main group, on the contrary, shows relative balance of regulatory systems. Thus, the conducted assessment of the state of cardiovascular system showed positive effects of using the complex of measures aimed at correction of functional state of operators during the course of the voyage.