bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Suberoylanilide Hydroxamic Acid Analogs Inhibit Angiogenesis and Induce
Apoptosis in Breast Cancer Cells
Authors: Moku Gopikrishna , Vangala Swathi , Yakati Venu , Gali Chaitanya C. , Saha Soumen , Madamsetty Vijay S. , Vyas Amber 
Published: September 2021

Background:
Histone deacetylases (HDACs) are the enzymes that catalyze the removal of the acetyl group
from lysine residues and regulate several biological processes. Suberoylanilide hydroxamic acid (SAHA) is a notable
HDAC inhibitor that exhibited remarkable anti-proliferative efficiency by alleviating gene regulation against solid and
hematologic cancers.

Aim:
The aim of this study was to develop new chemotherapeutic agents for breast cancer treatment, therefore, a
novel series of Suberoylanilide hydroxamic acid (SAHA) analogs were investigated as anticancer agents.

Methods:
We designed and synthesized a novel series of analogs derived from SAHA by substituting alkyl, alkoxy,
halo, and benzyl groups at different positions of the phenyl ring. The newly synthesized analogs were assessed for their
cytotoxic potential against four human cancer cell lines in comparison with healthy cell lines, using several biological
assays

Results:
SAHA analogs displayed significant cytotoxic potential with IC50 values ranging from 1.6 to 19.2 μM
in various tumor cell lines. Among these analogs, 2d (containing 3-chloro, 4-floro substitutions on phenyl moiety),
2h (containing 3,4-di chloro substitutions on phenyl moiety), and 2j (containing 4-chloro, 3-methyl substitutions
on phenyl moiety) showed significant cytotoxic potential with IC50 values ranging from 1.6 to 1.8 μM in MCF-7
(breast carcinoma) cell line. More importantly, these analogs were found to be non-toxic towards healthy primary
human hepatocytes (PHH) and mouse fibroblast cells (NIH3T3), which represent their tumor selectivity. These analogs
were further analyzed for their effect on cell migration, BrdU incorporation, Annexin V-FITC and cell cycle arrest
(Sub-G1 phase). Remarkably, analogs 2d, 2h, and 2j displayed significant HDAC inhibition than the parent SAHA
molecule. Further studies also confirmed that these SAHA analogs are efficient in inducing apoptosis, as they regulated
the expression of several proteins involved in mitochondrial or intrinsic apoptosis pathways. Findings in the Chick
Chorioallantoic Membrane (CAM) assay studies revealed anti-angiogenic properties of the currently described SAHA
analogs

Conclusion:
From anti-proliferative study results, it is clearly evident that 3,4-substitution at the SAHA phenyl ring
improves the anti-proliferative activity of SAHA. Based on these findings, we presume that the synthesized novel
SAHA analogs could be potential therapeutic agents in treating breast cancer.
Oncotherapeutic Application of Resveratrol-based Inorganic
Nanoparticles
Authors: Perris Angela , Bhattacharya Sanchari , Jawed Junaid Jibran , Hoda Muddasarul 
Published: September 2021

Background:
Potential therapeutic benefits of natural phytoconstituents and the emergence
of nano-structured drug delivery systems have expanded the scope of enhanced chemotherapy
with minimal adverse effects. Various in vivo and in vitro studies have revealed Resveratrol to
be a potent anti-carcinogenic agent. Researchers are currently applying the concept of nano-science
for enhancing the delivery of phyto-drugs like resveratrol, in order to carry the drug to the affected
tissues and organs of cancer patients with much ease and efficiency.

Methods:
The current review emphasizes the use of inorganic nanoparticles for enhancing the delivery
and efficacy of resveratrol into otherwise inaccessible tumorigenic tissues.

Conclusion:
The present review work summarizes a comprehensive update on the mechanism of
actions of the resveratrol-based inorganic nanocomposite particles that are currently being studied
against various cancer models. This work may be significant in laying the foundation for the future
of metallic nanoparticles-based delivery and efficacy of phytochemicals in general and resveratrol
in specific against non-invasive metastatic cancer.
Withdrawal Notice: Investigating the Anti-Angiogenic Effects of Elaeagnus angustifolia L. Extract In Vivo
Authors: Sako Mohammad , Zihlif Malek , Afifi Fatma 
Published: September 2021

The article has been withdrawn at the request of the authors of the journal Clinical Cancer Drugs.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

BENTHAM SCIENCE DISCLAIMER:
It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submit-ting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
Plant Extract Mediated Synthesis of Metal Nanoparticles, their Characterization
and Applications: A Green Approach
Authors: Jha Sudha Kumari , Jha Annapurna 
Published: September 2021

:
Nowadays, nanoparticles are gaining enormous importance in a wide variety of disciplines
due to their unambiguous physical and chemical properties. There are lots of physical and
chemical approaches available for the synthesis of metal nanoparticles. But there are certain disadvantages
associated with these methods, such as adsorption of hazardous toxins on the surface of the
material, high capital investment, high manufacturing energy demand, etc., which make their effective
implementation almost impossible. An alternative method of synthesizing nanoparticles to
avoid the aforementioned disadvantages is to use different parts of the plant under aqueous conditions.
Plant-mediated approach for the synthesis of nanoparticles is becoming increasingly popular
due to its faster reaction rate, easily affordable, eco-friendly nature and rich diversity of plants.
Chemical compositions of plant extracts are examined using the liquid chromatography-mass spectrometry
technique. Noble metals such as Silver, Gold, Iron, Copper, Platinum, Zinc, Palladium,
and their oxides are used for the fabrication of metal nanoparticles, due to their enormous potential
applications. In a single-step green synthesis process, the phytochemical constituents which are
present in plant extract reduce metal salts into metal nanoparticles. This article gives an overview of
plant-mediated synthesized metal and metal oxide nanoparticles and their characterization by using
different techniques, together with their properties and applications in numerous fields.
Elastic Guided Waves in Bistable Composite Structures - Experimental
and Numerical Investigation
Authors: Mustapha S. , Saad D.M. , Firouzian-Nejad A. , Aziz A. Abdul 
Published: September 2021

Background:
Bistable composite laminates are emerging as smart structures in automotive
and aerospace applications. However, the behavior of the wave propagation within such laminates
has not been investigated, which hinders their implementation in Structural Health Monitoring
(SHM) and Non-Destructive Evaluation (NDE).

Objective:
As a result, this manuscript examines the propagation behavior of guided waves in bistable
composite structures. By understanding the effect of pre-stressing in bistable composite laminates
on the characteristics of propagating waves, such as velocity and amplitude, a more knowledgeable
decision about their applications in flaw detection and assessment can be made.

Methods:
The fundamental symmetric (S0) and anti-symmetric (A0) Lamb wave modes were investigated
during propagation in two bistable composite laminates, [0/90]T and [02/902]T, and were assessed
experimentally and numerically using ABAQUS. For the tested frequencies, which ranged
from 60 kHz to 250 kHz, the behavior of the propagating wave was evaluated for both stable configurations
and across two different actuators that were lined up with the fiber directions. Signal
processing techniques were thus extensively used to enhance the measured signals and identify
both the group velocities and the amplitudes’ trend of the S0 and A0 wave modes.

Results:
Our results showed that there is a minimal variation (typically below 1%) in the amplitude
and velocity of the A0 and S0 modes when the composite plates switch between the first stable configuration
and the second stable configuration in both composite plates. These results were numerically
validated by replicating the bi-stability of the composites. The numerical data were in relatively
close agreement (10% average error) with the experimental values and trends. Furthermore,
the bistable effect was examined in detail relative to a reference numerical flat (monostable) plate.
Although the bistable effect induced a notable amount of internal residual stress, this did not significantly
impact the propagating wave modes, with a maximum difference of about 2% when comparing
wave velocities.

Conclusions:
The effect on the wave propagation behavior along different directions of both stable
configurations was shown to be minimal. These results, which were validated numerically, clear
the ambiguity on the usage of these laminates in experimental health monitoring.
La vulnerabilidad social en México
Authors: Cadena-Vargas Edel 
Published: September 2021

Esta investigación tuvo los siguientes objetivos: 1) construir un índice de vulnerabilidad social a escala detallada, 2) descubrir los patrones espaciales existentes, 3) determinar su distribución y asociación espacial y 4) identificar los clústeres de este indicador de desigualdad social. Se utilizó el censo de población de 2010. Se aplicaron las técnicas usuales de estadística convencional y estadística espacial. Los resultados obtenidos sugirieron que hay un proceso de segregación socioespacial y se relaciona con los flujos migratorios, informalidad económica, concentración de población indígena, y lejanía de los grandes centros urbanos de mayor actividad económica.
In Vitro Evaluation of Trichoderma asperellum Isolate UGM-LHAF against Rhizoctonia solani Causing Sheath Blight Disease of Rice
Authors: Nurhayati Yeyet , Suryanti Suryanti , Wibowo Arif 
Published: September 2021

Trichoderma spp. is a fungus widely used to control soil-borne pathogens, such as Rhizoctonia solani which is plant pathogenic fungi in widely host range, especially on rice. This research aimed to evaluate the ability of Trichoderma asperellum isolate UGM-LHAF against R. solani causing sheath blight disease of rice in vitro condition. Trichoderma sp. used in this research was obtained from The Biological Laboratory of Pakem, Yogyakarta, Indonesia, and Rhizoctonia sp. was obtained through isolation of diseased rice obtained from rice fields in Yogyakarta. The two isolates were characterized base on morphology and molecular identification based on ITS rDNA. The pathogenicity test of Rhizoctonia sp. was evaluated by adding four sclerotia of Rhizoctonia sp. near rice roots at 6 days after sowing. The in vitro test used dual culture and antifungal activity (0%, 10%, 25%, 50% culture filtrate of Trichoderma sp.) with three replicates of each treatment. Two isolates were identified as T. asperellum and R. solani. Sheath blight symptoms appeared after 12 days inoculation. In the in vitro test, T. asperellum isolate UGM-LHAF was able to inhibit the mycelial growth of R. solani (64.23% on dual culture and 68.5% on antifungal activity). This study suggests that T. asperellum isolate UGM-LHAF able to inhibit the growth of R. solani and can be a further potential candidate as a biocontrol agent against R. solani causing sheath blight disease of rice.
An observational cohort study of pelvic floor photobiomodulation for treatment of chronic pelvic pain
Authors: Kohli Neeraj , Jarnagin Barry , Stoehr Angela R , Lamvu Georgine 
Published: September 2021

Aim:
This research is the first to evaluate the effectiveness of
trans
-vaginal photobiomodulation therapy (TV-PBMT) for chronic pelvic pain.
Materials & methods:
Observational analysis of 128 women, undergoing TV-PBMT for chronic pelvic pain. Minimal clinically important difference, defined as ≥2-point drop on a 0–10 numeric pain rating scale (NPRS), and effect size Cohen d coefficient, was calculated over nine treatments for overall pain, and pain with activities.
Results:
Compared with baseline, 64.5% of women showed improvement in overall pain, pain with bowel movement, intercourse, exercise, urination, sitting and vulvar pain (minimal clinically important difference = -2.4, -2.0, -2.4, -2.1, -2.1, -2.0, -3.1; d = 0.9, 0.7, 0.9, 0.7, 0.7, 0.7, 0.9) by treatment 9.
Conclusion:
In this cohort, TV-PBMT resulted in improvement of pelvic pain without serious adverse events.
OBEDIENCE OF NON MUSLIM POLICEWOMEN IN ACEH IN WEARING THE VEIL UNIFORM
Authors: Mustaqilla Safira 
Published: September 2021

This study examines the compliance of 3 non-Muslim policewomen in three police institutions, in Ditlantas Aceh Regional Police, Jaya Baru and Baiturrahman Sector Police Banda Aceh, Nanggroe Aceh Darussalam, Indonesia. The main focus of this research is to explore the compliance of the 3 policewomen in wearing the veil uniforms. This research employed a qualitative method by examining case studies. The results of this study indicate that, there are several factors caused the obedience of 3 non Muslim policewomen officers in wearing the veil uniform, namely, first, adjusting to the office environment, second, respecting to the Islamic Sharia, the third, adhering to seniors and commanders. This article put the theory of Bourdieu. It related to compliance in accordance with the socio-cultural Aceh society and although the practice produces a variety of habits and conditions, but these three policewomen feel comfortable. This fact unconciously produce the Doxa, in which generated into an attitude of mutual respect, maintaining the tolerance and harmony for all parties, without distinguishing between ethnicities and the faith. The concept of obedience can be applied to shape the disciplined character, responsible and able to result the peaceful sphere.
Ṭawāf al-Mar’ah al-Ḥā’id fi al-Manẓar al-Islāmiy: Dirāsah Muqāranah bayn al-Madhāhib al-Fiqhiyyah al-Islāmiyyah
Authors: Qotadah Hudzaifah Achmad , Achmad Adang Darmawan 
Published: September 2021

One of the most important tasks in performing an obligation of worship is that a servant is required to learn the law as it was formed by sharia and religion, so that he could worship properly. Hajj is one of Islam's pillars where Islamic law requires all followers to run it for those who have the ability, even if only once in their lifetime, as He has said in the al-Qur’an: “Pilgrimage thereto is a duty men owe to Allah,- those who can afford the journey; but if any deny faith, Allah stands not in need of any of His creatures.” (QS: Al-Imran: 97). There are requirements in carrying out the Hajj and Umrah which should be fulfilled in their completion as a servant must manage, understand, etc. There are obligations to be performed in the conduct of Hajj and Umrah, and one is Ihram, Ramy al-Jamarat, stay a night in muzdalifah and so on. Furthermore, in the act of performing hajj and umrah there have been several pillars that must be performed such as tawaf. While as far as tawaf is concerned, there is an interesting discussion among many of the scholars on the issue of tawaf during Hajj and Umrah where it would be required to remain to purify during the hajj and umrah especially for a women within her menstruation cycle.
Glass Ionomer Versus Self-adhesive Cement and the Clinical Performance of Zirconia Coping/Press-on Porcelain Crowns
Authors: Torres CRG , Ávila DMS , Gonçalves LL , Meirelles LCF , Mailart MC , Di Nicoló R , Borges AB 
Published: September 2021

SUMMARY

Objective
This split-mouth clinical study investigated the effect of luting cement on the performance of veneered yttrium-stabilized tetragonal zirconia polycrystal (Y-TZP) zirconia crowns.

Methods and Materials
A total of 60 crowns prepared with Y-TZP coping and press-on porcelain were made with a split-mouth design in 30 participants. The crowns were cemented either with glass ionomer cement (GIC) (Meron, Voco) or with self-adhesive resin cement (Bifix-SE, Voco). The restorations were assessed immediately after treatment and after 6, 12, 24, 36, and 48 months using the modified United States Public Health Service criteria. The parameters analyzed were retention, color stability, marginal discoloration, marginal adaptation, surface roughness, anatomic form, and secondary caries. The differences between the groups were analyzed by the Fisher exact test in each period of evaluation. The survival rate was analyzed with the Kaplan–Meier and log-rank test (α=0.05).

Results
After 48 months, 20 participants attended the recall. During the period of evaluation, 1 crown cemented with glass ionomer cement and 1 crown cemented with resin cement lost retention. Color match, marginal discoloration and adaptation, surface roughness, and anatomic form did not change in any of the periods evaluated, and no secondary caries was observed. No significant differences were found between the 2 luting cements for any of the clinical parameters analyzed, nor for the survival rates during the study.

Conclusions
The type of cement did not influence the performance of the crowns after 48 months of clinical use. Both cements resulted in adequate retention rates, aesthetic and functional outcomes, and biological response.
The Correlation between Online Peer Review and Academic Writing Students’ Learning Styles
Authors: Aydawati Emilia Ninik , Rukmini Dwi , Bharati Dwi Anggani Linggar , Fitriati Sri Wuli 
Published: September 2021

Peer review studies have been done for years. It has been found that by having these activities, learners will get benefits from the communication with the peer who can give them input to improve their writing performance. Peer review can be done face to face or online. Face to face peer review is done synchronously where two students are having discussion on their essay, whereas online peer review can be done synchronously or asynchronously. This preliminary study investigates how the application of synchronous online peer review in Academic Writing class can be implemented to help them to do revision and improve their writing skills. The participants of this study is 50 students of academic writing class from two different class. This is an experimental study where the students were treated to get peer review activities from the software which is uploaded in web. They did the practice twice with the shuffled questions. This was aimed that they would be ready to give review. Pre-test and post-test were conducted and Gracian questionnaire to know their learning styles was uploaded in the web for them to fill in order to know their learning styles. it was found out that there are some improvement and there is correlation between their academic skills and the learning styles.
American Dark Romanticism Characteristics in Lenore
Authors: Harsono Khoe, Yohana , Dukut Ekawati Marhaenny 
Published: September 2021

Abstract: Analyzing the words and phrases used in Edgar Allan Poe’s Lenore can portray the characteristics of the Dark Romanticism era of the United States of America, which consist of 1) imagination, 2) nature, 3) symbolism and myth, 4) intuition and subjectivity, and 5) individualism. Through a biographical and sociological approach, it was found that there were words in Lenore that support the Dark Romanticism characteristics. The dark, creepy, gloomy, and dreary, words that hint the feeling of Poe’s uneasiness while living a dark and difficult life in the 1800s in America were “no tear… weep now”, “grief and groan”, “Stygian River”, “golden brown”, “Hope”, “Peccavimus”, “Lenore” and “death”.Key words: Edgar Allan Poe, poem, romanticism era, dark romanticism, LenoreAbstrak: Menganalisis kata-kata yang digunakan oleh Edgar Allan Poe dalam puisinya Lenore dapat memperlihatkan karakteristik dari masa Dark Romanticism yang dialami oleh negara Amerika Serikat, yaitu adanya karakteristik: 1) imagination, 2) nature, 3) symbolism and myth, 4) intuition and subjectivity, dan 5) individualism. Melalui pendekatan biografi dan sosiologi maka ditemukan beberapa kosa kata dari puisi Lenore yang mendukung masa Dark Romanticism yang dipenuhi dengan lingkungan yang gelap, menyeramkan, dan menyedihkan itu. Beberapa kosa kata yang menandakan ketidaknyamanan Poe dalam melalui kehidupannya pada tahun 1800an di Amerika Serikat adalah kata “no tear… weep now”, “grief and groan”, “Stygian River”, “golden brown”, “Hope”, “Peccavimus”, “Lenore” and “death”.Kata kunci: Edgar Allan Poe, puisi, era romantisisme, dark romanticism, Lenore
Augmented Reality dalam Proses Desain Arsitek Masa Depan
Authors: Wastunimpuna Benediktus Yosef Arya , Purwanto L.M.F. 
Published: September 2021

Dunia arsitektur sedang mengalami sebuah tekanan terkait hasil karya dari para arsitek yang secara kuantitas sudah banyak namun dinilai kurang secara kualitas. Hal ini disebabkan karena dalam proses desain yang dilakukan oleh arsitek ditemukan gap yang cukup lebar antara konsep dengan praktek perancangannya. Oleh karena itu banyak arsitek yang mulai melirik dunia digital terutama augmented reality sebagai media yang dapat membantu proses mendesain. Augmented Reality memang memiliki kelebihan dalam menyajikan visual 3D yang sangat berguna bagi dunia arsitektur yang juga bermain dengan visual. Namun hingga sekarang augmented reality masih hanya diaplikasikan sebagai media informasi digital pada bangunan yang telah terbangun. Padahal jika melihat perkembangannya teknologi ini mampu untuk bermanfaat lebih dari itu. Sehingga tujuan dari penelitian ini adalah menganalisa dan mengindikasikan potensi penggunaan augmented reality pada proses desain seutuhnya. Metode yang digunakan adalah literature review dengan mencari literatur yang relevan kemudian melakukan sintesi analisanya. Dan pada akhir penelitian ditemukan bahwa augmented reality tidak hanya berfungsi sebagai media informasi dari hasil desain akan tetapi dapat ditempatkan dalam semua tahapan desain yaitu analisa, sintesis dan evaluasi.
A study on audit report timeliness: The Macedonian Stock Exchange
Authors: Srbinoska Dusica Stevcevska , Srbinoski Igor 
Published: September 2021

Abstract
Financial statements reflect important information about the entity's financial position, operating performance, and cash flows and must be made available in a timely fashion to all interested factions to stimulate opportune business judgments.
Ergo, this paper examines the association of the audited annual report delay with eight entity and audit firm attributes.
The sample includes 396 observations of 99 nonfinancial firms listed on the Macedonian Stock Exchange (MSE) for the period 2014–2017. The regression results designate a statistically significant relationship between the audit opinion, company liquidity, size, and industry with the audit opinion lag. Moreover, the publication period ranges from 43 days to 374 days suggesting that timeliness may be a significant concern for Macedonian entities regarding financial reporting policy.
This is the first study to thoroughly assess the relationship between entity, auditor characteristics, and audit report timeliness on the developing Macedonian market.