bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corrective Actions Taxonomy for Healthcare Incidents (CATHI): Insights From Real-world Data on Hospital-reported Incidents
Authors: Brazete Cátia , Marques António Miguel , S. Elsa Isaura , De Freitas Cláudia , Azevedo Ana 
Published: December 2024

Objectives:
This study aimed to develop a taxonomy for classifying corrective actions following health care incidents in a Portuguese tertiary hospital.

Methods:
The study utilized a multimethods design, combining qualitative and quantitative analyses of real-world data. Thematic analysis was performed, drawing on inductive and deductive approaches. The latter was informed by the PRISMA Medical Classification/Action Matrix and the COM-B theory.

Results:
A total of 4644 incidents were reported between January 1, 2021 and December 31, 2022. Each incident report is accompanied by an unstructured free-text conclusion section, whose content was manually coded using NVivo QRS. A total of 910 corrective actions were found. The process of classifying these actions, in addition to the deductive approach, served as the foundation for the development of the proposed taxonomy—the Corrective Actions Taxonomy for Healthcare Incidents (CATHI). CATHI included themes such as technology, medical devices, equipment and infrastructure, procedures, information and communication, and training, among others. The taxonomy was structured into 3 levels to allow for a more detailed classification of corrective actions. A glossary was developed to improve usability, including definitions and examples derived from real-world data.

Conclusions:
CATHI provides a standardized approach to action implementation, allowing for prioritization of improvement efforts. This study has practical implications for enhancing patient safety and quality of care. Future research should validate this taxonomy in diverse health care settings.
Elevated cell-free hemoglobin: A novel early biomarker following traumatic injury
Authors: Ross James T. , Robles Anamaria J. , Barnes Ashli , Bellini Alyssa R. , Mansour Alexandre , Nesseler Nicolas , Reynolds James D. , Remy Kenneth E. , Callcut Rachael A. 
Published: December 2024

BACKGROUND
Cell-free hemoglobin (CFH) and free heme are potent mediators of endotheliopathy and organ injury in sepsis, but their roles in other hemolytic pathologies are not well-defined. A prime example is trauma where early hemolysis may initiate damage and predict outcome. Here, we investigated the presence of plasma CFH, heme, and their major scavengers after traumatic injury.

METHODS
Adult patients who presented as highest-level activations were prospectively enrolled at a level 1 trauma center between 2021 and 2023. Venous blood was collected upon arrival (pretransfusion) and 6, 12, and 24 hours after admittance for quantification of CFH, haptoglobin, heme, and hemopexin.

RESULTS
We studied 119 mostly male subjects (101:18) with a median age of 48 years (interquartile range [IQR], 31–64 years) and an Injury Severity Score of 22 (IQR, 11–29); the majority had suffered blunt force trauma. The 28-day mortality rate was 11%. Cell-free hemoglobin was high upon emergency department arrival (10.9 μM; IQR, 6.8–17.6) and then declined but remained elevated compared with normative levels during the monitoring period (>5 vs. ~0.2 μM). The initial drop in CFH was attributed to haptoglobin binding and clearance. Notably, there was a subgroup of patients with two- to threefold higher levels of CFH on emergency department arrival (median, 25 μM). Patients with these highest CFH levels had longer hospital stays and more frequent complications.

CONCLUSION
Cell-free hemoglobin is elevated in trauma patients very early after injury and may impact outcome. While further work is needed, early correction of hemolysis could provide benefit.

LEVEL OF EVIDENCE
Prognostic/Epidemiological Study; Level III.
Use of Ex Situ Machine Perfusion for Liver Transplantation: The National Experience
Authors: Zhou Alice L. , Akbar Armaan F. , Ruck Jessica M. , Weeks Sharon R. , Wesson Russell , Ottmann Shane E. , Philosophe Benjamin , Cameron Andrew M. , Meier Raphael P.H. , King Elizabeth A. 
Published: December 2024

Background.
Machine perfusion (MP) for liver transplantation has become more widespread in the United States, but national studies on this growing practice are lacking. We investigated national use and outcomes of MP for liver transplantation.

Methods.
Adult (≥18 y) liver recipients transplanted between January 1, 2016 and September 30, 2023 in the United Network for Organ Sharing database were included. We used Cox regression to compare 1-y posttransplant recipient survival and all-cause graft failure by use of MP and performed subgroup analyses among circulatory death (DCD) and brain death (DBD) donors.

Results.
Of 52 626 deceased donors with liver recovery, 1799 (3.5%) utilized MP. The proportion of all liver transplants using MP increased from 0.3% in 2016 to 15.5% in 2023. MP for DCD transplants increased from 0.8% in 2016 to 50.0% in 2023. Donors of MP grafts were older (47 [34–57] versus 42 [29–55] y, P < 0.001), had higher body mass indexes (28.3 [24.4–33.3] versus 27.3 [23.7–31.8] kg/m2, P < 0.001), and were more likely to be DCD (47.1% versus 9.3%, P < 0.001). Among DBD transplants, MP and non-MP DBD transplants had similar all-cause graft failure out to 1 y (adjusted hazards ratios, 1.12 [95% confidence interval, 0.87–1.43], P = 0.38). Among DCD transplants, MP recipients had improved survival out to 1 y (adjusted hazards ratios, 0.50 [95% confidence interval, 0.35–0.70], P < 0.001).

Conclusions.
MP use in liver transplantation is rapidly expanding and is associated with favorable outcomes compared with cold storage. MP is associated with increased posttransplant survival for DCD transplants, highlighting the potential for MP to expand utilization of DCD grafts.
Mammalian ZAP and KHNYN independently restrict CpG-enriched avian viruses
Authors: Becker Jordan T. , Mickelson Clayton K. , Pross Lauren M. , Sanders Autumn E. , Vogt Esther R. , Shepherd Frances K. , Wick Chloe , Barkhymer Alison J. , Aron Stephanie L. , Fay Elizabeth J. , Harris Reuben S. , Langlois Ryan A. 
Published: December 2024

ABSTRACTZoonotic viruses are an omnipresent threat to global health. Influenza A virus (IAV) transmits between birds, livestock, and humans. Proviral host factors involved in the cross-species interface are well known. Less is known about antiviral mechanisms that suppress IAV zoonoses. We observed CpG dinucleotide depletion in human IAV relative to avian IAV. Notably, human ZAP selectively depletes CpG-enriched viral RNAs with its cofactor KHNYN. ZAP is conserved in tetrapods but we uncovered that avian species lack KHNYN. We found that chicken ZAP does not affect IAV (PR8) or CpG enriched IAV. Human ZAP or KHNYN independently restricted CpG enriched IAV by overexpression in chicken cells or knockout in human cells. Additionally, mammalian ZAP-L and KHNYN also independently restricted an avian retrovirus (ROSV). Curiously, platypus KHNYN, the most divergent from eutherian mammals, was also capable of direct restriction of multiple diverse viruses. We suggest that mammalian KHNYN may be abona fiderestriction factor with cell-autonomous activity. Furthermore, we speculate that through repeated contact between avian viruses and mammalian hosts, protein changes may accompany CpG-biased mutations or reassortment to evade mammalian ZAP and KHNYN.SIGNIFICANCEViruses adapt to hosts to replicate successfully. We show that two mammalian proteins, ZAP and KHNYN, restrict CpG-enriched avian viruses. Mammalian KHNYN may be abona fiderestriction factor with cell-autonomous activity. We also identified a platypus KHNYN with potent and broad antiviral activity highlighting a significant need to investigate antiviral mechanisms in novel and understudied species. Ongoing efforts to understand viruses with zoonotic potential will benefit from further identification of species-/class-specific restriction factors and their antiviral preferences. Furthermore, we speculate that evolving viral nucleotide composition indicates zoonotic potential and adaptation to mammals requires dinucleotide and amino acid changes.HIGHLIGHTSCpG content is depleted in human and swine IAV relative to avian IAVHuman ZAP-S and KHNYN but not chicken ZAP independently restrict CpG-rich IAV.Mammalian ZAP-L and KHNYN but not chicken ZAP independently restrict ROSV.Platypus KHNYN potently restricts retroviruses, including IAV, HIV-1, MLV, and ROSV.
‘Proteomic characterization and Molecular Mechanism of Goat Whey Protein-Derived Bioactive Peptides as Pancreatic Lipase and α-Amylase Inhibitors’
Authors: Sansi Manish Singh , Iram Daraksha , Kumar Sudarshan , kapila Suman , Meena Sunita 
Published: December 2024

AbstractGoat whey protein (GWP) is a valuable source of bioactive peptides with diverse health-promoting properties. In this study, GWP was enzymatically hydrolysed by gastrointestinal enzymes (pepsin (P), trypsin (T) and chymotrypsin (C)) combination to release whey protein peptides (WPP), which were identified and characterized using high-resolution liquid chromatography-mass spectrometry (HR-LC/MS). A total of 2,883 peptides were identified, with peptide lengths ranging from 6 to 44 amino acids, of which 40 were predicted to exhibit bioactivity score between 0.90-1 using PeptideRanker. 28 were predicted as nontoxic out of 40 bioactive peptides. Molecular docking simulations were conducted to explore the binding interactions of these peptides with pancreatic lipase and α-amylase—key enzymes involved in lipid and carbohydrate metabolism. The analysis revealed that specific peptides demonstrated strong binding affinities to both enzymes, suggesting their potential as enzyme inhibitors. Notably, peptides WPGIMR and WQDGSWQF exhibited the highest binding affinity to pancreatic lipase, while AAPFIWL and WQDGSWQF showed strong interactions with α-amylase. These findings highlight the molecular mechanisms underlying the inhibitory activities of whey protein-derived peptides, supporting their potential application as functional food ingredients or therapeutic agents for managing metabolic disorders such as obesity and diabetes. This study advances our understanding of whey protein hydrolysates as a source of bioactive peptides and their role in modulating key metabolic enzymes.
Spectroscopic properties of double-strangeness molecular tetraquarks
Authors: Wang Fu-Lai , Luo Si-Qiang , Qian Ri-Qing , Liu Xiang 
Published: December 2024

Inspired by recent advances in the study of the K(*)K¯(*) molecular tetraquarks and the H-dibaryon, we focus on the spectroscopic properties of the K¯(*)K¯(*) systems, which exhibit an exotic flavor quantum number of ssq¯q¯. A dynamical analysis is performed using the one-boson-exchange model to describe the effective interactions for these systems, accounting for both S−D wave mixing and coupled-channel effects. By solving the coupled-channel Schrödinger equation, we identify the I(JP)=0(1+) K¯K¯* and I(JP)=0(1+)K¯*K¯* states as the most likely candidates for double-strangeness molecular tetraquarks. Furthermore, we estimate their strong decay behaviors based on the effective Lagrangian approach, with several channels exhibiting considerable decay widths. Meanwhile, we investigate their magnetic moments and M1 radiative decay widths, shedding light on their inner structures, within the constituent quark model. Finally, we encourage experimentalists to focus on these predicted double-strangeness molecular tetraquark candidates, particularly in B meson decays. Such efforts could pave the way for establishing the molecular tetraquark states in the light-quark sector.

Published by the American Physical Society
2024
Crafting the future workforce: a Fleiss Kappa exploration of Industry 4.0 talent perspectives
Authors: Mazlan Muhammad Haziq , Puteh Saifullizam , Mohamad Zunuwanas , Sulaiman Nor Lisa , Mohd Salleh Kahirol , Wan Omar Wan Rosemehah , Buhari Rosnawati , Mp Hartoyo 
Published: December 2024

PurposeThis study aims to identify and explore the critical components of Industry 4.0 (IR4.0) talent domains needed by Technical and Vocational Education and Training (TVET) students through work-based learning (WBL) programs in Malaysia.Design/methodology/approachA qualitative research design was employed, involving semi-structured interviews with 11 experts from academia and industry. Document analysis was employed to complement expert interviews, offering an enriched understanding of the IR4.0 talent domains. Data were analysed using thematic analysis and reliability analysis through Fleiss’s Kappa.FindingsThe study reveals a consensus between academic and industry experts on the importance of cognitive abilities and professionalism for IR4.0 talent. However, significant discrepancies were noted in the domain of operational work skills, with academic experts agreeing on 12 out of 14 components, while industry experts agreed on only four. This highlights a potential misalignment between academic curricula and industry needs, particularly in operational skills.Research limitations/implicationsThis research only involves academics and industry experts in the field of IR4.0. The focus of this research is on the undergraduate WBL programmes at Malaysia’s Polytechnic.Practical implicationsThe findings can guide curriculum development in TVET programs, ensuring that students are equipped with the necessary skills to meet industry expectations.Originality/valueThis research contributes to the ongoing discourse on IR4.0 talent development, offering valuable insights into the essential talent domains for TVET students engaged in WBL programs. The findings underscore the need for closer collaboration between educational institutions and industry to ensure that TVET programs are better aligned with the demands of the IR4.0 workforce.
“Lesson Study is not a revolution, but an evolution”. Sustainability of Lesson Study, explored in a Norwegian context
Authors: Karlsen Anne Mette Færøyvik , Helgevold Nina 
Published: December 2024

PurposeEfforts in using Lesson Study (LS) as a tool for Professional Development (PD) has in a Norwegian context often tended to be short-lived. Some schools have managed to find solutions for sustainability, and a selection of these are the focus of this study. The objective is to explore supportive factors for sustainability.Design/methodology/approachThis is a case study that explores how LS has been organized and developed in a cluster of three schools in a municipality at the west coast of Norway. These schools have been selected through a purposeful selection based on their long-lasting persistence in using LS as a tool for PD. Data is retrieved from interviews with school leaders and teachers (process facilitators), in addition to teacher surveys.FindingsOne of the most important factors for sustainability in LS was found to be school leaders’ commitment, knowledge and engagement in LS. Further, the results highlight “anchoring” LS in the teacher group and securing the relevance of LS in relation to the curriculum. The school leader groups in this study have involved teachers by including them as process facilitators and considered teachers’ views on the content and organizing of LS. Additionally, university collaboration, networking among local schools and schools abroad, knowledge resources and structures (for the LS work) were important factors for sustainability. The step-by-step process of building a culture for LS allowed LS to be a dynamic approach to the schools’ PD.Originality/valueThis is the first study that has investigated possible explanations for sustainability of LS in a Norwegian context. The findings can serve as an inspiration or a guide to a sustainable LS approach.
Integrating AI into global fluid healthcare workforces: student perspectives and future trends
Authors: Bilderback Stephanie , Movahed Mohammad 
Published: December 2024

PurposeThis study investigates healthcare administration students’ perspectives on integrating artificial intelligence (AI) in fluid healthcare work environments, focusing on its potential impact on future healthcare practices.Design/methodology/approachThe research utilizes a mixed-methods strategy, combining quantitative surveys and qualitative interviews to collect data from healthcare administration students at a mid-sized urban university. This comprehensive approach allows for an in-depth analysis of students’ understanding of, attitudes toward and expectations of AI in healthcare settings.FindingsResults reveal that students have a nuanced understanding of AI’s capabilities to enhance healthcare operations and patient care, showcasing readiness to adopt these technologies. Nonetheless, there are significant concerns about job security and the depersonalization of care with the integration of AI. The study highlights the critical need for healthcare curricula to evolve to incorporate AI training that equips future professionals to use these technologies in increasingly flexible work settings.Originality/valueThis research offers new perspectives on how future healthcare professionals view AI integration within evolving work arrangements. It emphasized the need for educational institutions to update and adapt educational frameworks to prepare a workforce that can effectively navigate the challenges and opportunities presented by AI in the healthcare sector. This is particularly relevant in fluid work dynamics, where adaptability and responsiveness are key.
AI-powered leadership: a systematic literature review
Authors: Aziz Muhammad Faisal , Rajesh J. Irudhaya , Jahan Fazilat , McMurrray Adela , Ahmed Nisar , Narendran Roshni , Harrison Christian 
Published: December 2024

PurposeIn this era of rapid technological advancement, Artificial Intelligence (AI) has emerged as a crucial factor in reshaping organisational dynamics, notably in the realm of leadership. This systematic literature review (SLR) aims to investigate the emerging relationship between AI and leadership, focussing on defining AI-powered leadership, identifying prevalent themes, exploring challenges, and uncovering research gaps within the relevant literature.Design/methodology/approachA sample of 73 papers was chosen after carefully applying the inclusion and exclusion criteria to 1,387 research articles that were initially sought. Using the methodological framework presented by Denyer and Tranfield (2009), our study adopted a four-step procedure to obtain insights from the corpus of literature. The papers were analysed by employing content and thematic analysis to address four key questions.FindingsThe review explores various definitions of AI-powered leadership proposed in the literature based on real-world situations. The study further synthesises significant themes in the existing literature, such as the past, present and future of AI and AI in various facets of organisational leadership, transitional management, and urban management. The review revealed a range of key challenges in AI-powered leadership, including ethical dilemmas, complications in human-AI interactions, hurdles in AI implementation within leadership contexts, and long-term risks associated with AI integration. In addition, this study identified areas within AI-powered leadership research that require further investigation by revealing significant research gaps in the papers.Originality/valueBy adopting a comprehensive approach, this research advances understanding of the complex relationship between AI and leadership dynamics, thus facilitating comprehension of the current body of knowledge and enabling future scholarly investigations in the AI-powered leadership domain.
Assessing the alignment of a University of Technology Library infrastructure with the Fourth Industrial Revolution: implications for librarian roles
Authors: Moonasar Anushie 
Published: December 2024

PurposeThis study aims to evaluate how well a University of Technology Library’s infrastructure aligns with the requirements of the Fourth Industrial Revolution (4IR). By examining the current state of technological integration and identifying potential gaps, this research seeks to provide insights into the necessary developments and adaptations needed. Additionally, the study explores the implications of these changes for librarian roles, highlighting the evolving skill sets and competencies required in this new paradigm.Design/methodology/approachThe study used a mixed methods research approach, integrating an online questionnaire to gather quantitative data and conducting interviews to obtain qualitative insights. The subsequent interviews offered a thorough understanding of the library’s alignment with the 4IR and its implications for the librarians at the library.FindingsThe findings of this research will offer valuable perspectives for university faculties, librarians and policymakers in shaping future-ready library environments that support innovative teaching, learning and research practices.Practical implicationsThe findings highlight the need for academic libraries to continuously evolve with enhancements to existing infrastructure to incorporate advancing technologies and encompass modern digital platforms, tools and resources to support innovative teaching, learning, and research works.Originality/valueThis study provides insight into the results of the importance of evolving with the advances of technologies in academic institutions within a developing country in Africa.
Networking capabilities on organizational networking in entrepreneurial SMEs
Authors: Marcano Nieves Leila M. , Sosa-Varela Juan C. , Ortiz Maribel , Montalvo Francisco 
Published: December 2024

Purpose
This study investigates the impact of top management’s networking capabilities on the organizational networking and absorptive capacities of small and medium-sized enterprises (SMEs) in Puerto Rico. This study aims to enhance understanding of how top management influences the networking behaviors that drive SME performance.

Design/methodology/approach
Data were collected from Puerto Rican SMEs and analyzed using multi-item reflective indicators on a five-point Likert scale. Partial least squares structural equation modeling was used to test the hypotheses and explore relationships between networking capabilities and absorptive capacities.

Findings
The study finds that top management’s networking capabilities are predominantly reactive, significantly impacting information acquisition, opportunity enabling and weak-tie resource mobilization. Both potential and realized absorptive capacities are critical for SMEs to leverage resources for competitive advantage.

Research limitations/implications
Further research is needed to explore how these findings apply to other regions or industries and expand on the role of proactive networking in enhancing SME competitiveness.

Practical implications
The study underscores the importance of refining proactive and reactive networking capabilities to sustain competitive advantage in dynamic environments.

Social implications
Puerto Rico’s unique economic context, including natural disasters and economic downturns, makes the findings relevant for SMEs in similar regions that rely on strong networks for resilience.

Originality/value
This research contributes to the dynamic capabilities literature by confirming SMEs’ proactive and reactive networking dimensions. It also offers a unique perspective by focusing on Puerto Rican SMEs facing distinct economic and social challenges.