bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Powered Cardiac Pacemaker Using RC4 Algorithm
Authors: Elavarasi K , Deepa J 
Published: January 2021

Abstract
In this paper is to style frustration safe rate-responsive SA center contraption that would be checked and created by an authority using an ensured about far off correspondence. The contraption code is predicated upon a real troublesome stretch working system (RTOS) part and subsequently, the device sensibility is ensured about and is planned to avoid dissatisfactions because of PC code breakdowns. Exquisite pacemaker’s zone unit programmable and awards the master to pick the ideal pacing modes for solitary patients. All together that crucial circumstance is normally avoided and preventive measure an area unit with progress approved.
Enhancing Network Coverage Using Sensing Models in Wireless Sensor Network
Authors: Vidhya J , Prasanna P , Margarat M , Jayalakshmy S 
Published: January 2021

Abstract
WSN is a wireless network made of wireless sensors that is used to monitor the system, environmental or physical conditions. Network coverage is a critical Quality of Service parameter in the design of WSN. The sensing model used to design the network decides the coverage. In this paper, the effects on sensing coverage by multi-path fading and shadowing effects have been studied. A model for calculating coverage probability has been derived for an environment in presence of shadowing effect combined with multi-path fading. Deployment scheme directly influences the performance of the WSN. A multiple deployment scheme is proposed for shadowed and non-shadowed environments using Rayleigh and shadow fading. For the same value of sensing coverage, a significant depreciation in the required number of nodes is shown.
Design and Development of Future Estimate in Confronting Ransomware
Authors: Balachandar A. , Abdul Alsowdh S. , Arumugam K. 
Published: January 2021

Abstract
Ransomware might be a one assortment of malignant PC code which is that the quickest spreading malware risk as they focusing on each kind of clients records result in brief or perpetual loss of touchy information issue to ordinary activities, cash misfortunes caused to resuscitate framework documents that partners potential hurt to an association. As a consequences of an essential information’s unit encoded on the pc arrange by the programmers which they request the payment to pay a computerized cash style of a bitcoin inside a particular date, if installment isn’t done no information are back to unique sort of mystery composing. The proposed framework demonstrates that gathering of bitcoin datasets are accustomed to anticipating the eventual fate of bitcoin rates then examination the ransomware, that investigation are utilized to discover the ransomware extends then the client can shutting the framework doors for keeping away from the trail technique for malware go into the framework. It shows the security measures for the framework from the ransomware prediction.
A Simple Feature Extraction Method for Analysis of Hand Written Characters
Authors: Vijayprasath S. 
Published: January 2021

Abstract
The printed and handwritten alphabets as character recognition by feature extraction are described during this proposed work. A predefined set of 108 samples each containing twenty-six alphabets taken by paper handwritten are taken as set for training. The system portrayed is a good alternative solution for HCR & plays well with detection of handwritten characters. Here, the method experiences binarization and pre-processing for the segmentation stage. Individual characters after segmentation undergo feature extraction part. The artificial neural network is trained using the extracted features. A simple ANN is used as a classifier utilizing the average epochs and MSE for detecting the HCR recognition without a false alarm.
Motion detection using Passive Infrared Sensor using IoT
Authors: Sasi G. 
Published: January 2021

Abstract
An IoT is the recent trend today which is applicable to all the real time applications. It is applied in all the sectors like smart city, home, appliance, Security as most important one which reduces the human operation and do all the works are done in automation. This will useful in all the areas and easy implementation. In that sense, in this paper I suggested the concept of Infrared radiation for motion detection by using PIR sensor. That sensor is implemented with the microcontroller which identifies the intruders movement which represented by high and low. This represents the motion detection, if the value is high there is a motion of intrusion, otherwise if the value is low it shows does not intruded by anyone. This technique is very compatible because only it requires three components it is detected by mixed signal processor and line transceiver.
Investigations on the Physical Parameters and Real Time Protection of Distributed Transformers using Internet of Things
Authors: Balraj B , Sridevi A , Amuthameena S , Elizabeth Caroline B 
Published: January 2021

Abstract
This paper presents the design and implementation of a mobile embedded system to monitor load currents, over voltage and transformer temperature. The on-line supervising system integrates global system for mobile communication (GSM) modem, with node microcontroller unit (MCU), sensors and transformers. It was installed at the distribution transformer site. The output values of sensors and transformers were processed and recorded in the cloud using internet on things. System programmed with some predefined instructions to check abnormal conditions. If there is any abnormal value found in the system, the GSM module will send messages to selected mobile at the same time it cut off the supply form the load. Every half an hour it send actual value of current, voltage and temperature of transformer. This mobile system will help the utilities to protect transformer and identify problems before any extremely failure happens. For future analysis it retrieve data from cloud using think speak platform. This system will be an advanced step to the automation by reducing human dependency and increases the reliability of distribution network.
Epigenetic regulation of virulence and the transcription of ribosomal protein genes involves a YEATS family protein in Cryptococcus deneoformans
Authors: Li Chenxi , Hou Shaonan , Ma Xiaoyu , Li Jiajia , Huo Liang , Zhang Ping , Hao Xiaoran , Zhu Xudong 
Published: January 2021

ABSTRACT
Epigenetic marks or post-translational modifications on histones have important regulatory roles in gene expression in eukaryotic organisms. The epigenetic regulation of gene expression in the pathogenic yeast Cryptococcus deneoformans remains largely undetermined. The YEATS domain proteins are readers of crotonylated lysine residues in histones. Here, we reported the identification of a single-copy gene putatively coding for a YEATS domain protein (Yst1) in C. deneoformans. To define its function, we created a mutant strain, yst1Δ, using CRISPR-Cas9 editing. yst1Δ exhibited defects in phenotype, for instance, it was hypersensitive to osmotic stress in the presence of 1.3 M NaCl or KCl. Furthermore, it was hypersensitive to 1% Congo red, suggesting defects in the cell wall. Interestingly, RNA-seq data revealed that Yst1p was critical for the expression of genes encoding the ribosomal proteins, that is, most were expressed with significantly lower levels of mRNA in yst1Δ than in the wild-type strain. The mutant strain was hypersensitive to low temperature and anti-ribosomal drugs, which we putatively attribute to the impairment in ribosomal function. In addition, the yst1Δ strain was less virulent to Galleria mellonella. These results generally suggest that Yst1, as a histone modification reader, might be a key coordinator of the transcriptome of this human pathogen. Yst1 could be a potential target for novel antifungal drugs, which might lead to significant developments in the clinical treatment of cryptococcosis.
Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.
Authors: Lander E S , Botstein D 
Published: January 2021

Abstract
The advent of complete genetic linkage maps consisting of codominant DNA markers [typically restriction fragment length polymorphisms (RFLPs)] has stimulated interest in the systematic genetic dissection of discrete Mendelian factors underlying quantitative traits in experimental organisms. We describe here a set of analytical methods that modify and extend the classical theory for mapping such quantitative trait loci (QTLs). These include: (i) a method of identifying promising crosses for QTL mapping by exploiting a classical formula of SEWALL WRIGHT; (ii) a method (interval mapping) for exploiting the full power of RFLP linkage maps by adapting the approach of LOD score analysis used in human genetics, to obtain accurate estimates of the genetic location and phenotypic effect of QTLs; and (iii) a method (selective genotyping) that allows a substantial reduction in the number of progeny that need to be scored with the DNA markers. In addition to the exposition of the methods, explicit graphs are provided that allow experimental geneticists to estimate, in any particular case, the number of progeny required to map QTLs underlying a quantitative trait.
Risk of overanticoagulation during acute kidney injury in patients treated with vitamin K antagonists
Authors: Süfling Luisa , Greinert Daniel , Girndt Matthias 
Published: January 2021

Abstract

Background
Vitamin K antagonists (VKAs) are still in use for oral anticoagulation, but not all indications allow their replacement by direct oral anticoagulants. Although formal dose reduction is not required in patients with impaired kidney function, case reports indicate that acute kidney injury (AKI) might be associated with derailment of VKA therapy.

Methods
The study retrospectively collected patients from a tertiary nephrology care centre who experienced AKI while being treated with VKA. In these individuals, the international normalized ratio (INR) as a measure of anticoagulant effect during renal failure was compared with a reference time point with stable kidney function.

Results
A total of 100 patients with AKI and ongoing VKA therapy met the inclusion criteria. The majority (76%) of patients had AKI with CKD. Volume depletion (n = 43), septic renal failure (n = 22), decompensated heart failure (n = 18) and toxic renal damage (n = 11) were the most important causes of AKI. The average INR values at the time of AKI were higher than at the reference time point [median 3.17 (range 1.10–13.0) versus 2.24 (1.07–5.17); P &lt; 0.0001]. Fifty-four patients had INR values above the recommended therapeutic range for their indication at the time point of AKI. Bleeding complications occurred in 24 patients during AKI and the VKA dose had to be reduced in 55. Women, patients with low body mass index and patients with diabetes were predisposed to overanticoagulation during AKI.

Conclusions
The effect of AKI on anticoagulation by VKA has not been systematically described. This risk should be considered in patients at high risk for AKI.
Socioecological Mapping of Barriers and Enablers to Smoking Cessation in Indigenous Australian Women During Pregnancy and Postpartum: A Systematic Review
Authors: Rahman Tabassum , Eftekhari Parivash , Bovill Michelle , Baker Amanda L , Gould Gillian S 
Published: January 2021

Abstract

Background
With a high prevalence of smoking during pregnancy and limited Indigenous-specific evidence for treatment, we used socioecological mapping to identify multilevel barriers and enablers to smoking cessation related to Indigenous Australian pregnant and postpartum women.

Methods
Nine electronic databases were searched. Original studies except interventions and trials, published in English, up to February 29, 2020 were included. Studies were appraised using the QualSyst tool. Evidence was narratively synthesized. The review protocol was registered with PROSPERO (CRD42019135543).

Results
A total of 15 studies (10 quantitative, 5 qualitative) were included, covering 1306 women, 3 partners/family members, 234 health professionals (HP), and 2755 patient records. Complex and overlapping barriers were identified at individual, family, community, societal, and system levels. Socioeconomic disadvantages, inequality, and pervasive racism as legacies of colonization, combined with personal, family, and community circumstances intensified individual experiences of stress, which may be heightened during pregnancy. Inadequate smoking cessation care (SCC), inconsistent antitobacco messages, and ineffectual HP interventions underscore a need for service enhancement and further evidence to develop culturally relevant messages. High motivation of pregnant women to quit, resilience, and supports available in the family and community are strengths that warrant attention in future interventions.

Conclusions
SCC without ameliorating the social disadvantages and the disparities in health determinants between Indigenous and non-Indigenous Australian women may limit the effectiveness of SCC. A comprehensive approach is required that includes policy changes for addressing external stressors the women experience, engagement of family and community, and better training of HP and provision of free pharmacotherapy.

Implications
To systematically address barriers to smoking cessation at multiple levels, initiatives to ameliorate social disadvantages and discrepancies in social determinants of health between Indigenous and non-Indigenous Australians are required to be taken in tandem with SCC. Initiatives may include making relevant policy changes and allocating more resources for education, employment, housing, and community development. Enhancement of knowledge, skills, and confidence of HP regarding the provision of high-quality SCC for Indigenous women and their families is warranted. Future interventions may build on high motivation, resilience, and strengths of individual women, and incorporate support strategies engaging family and community.
Say my name, say my name: Academic authorship conventions between editorial policies and disciplinary practices
Authors: Hesselmann Felicitas , Schendzielorz Cornelia , Sorgatz Nikita 
Published: January 2021

AbstractAcademic publishing is undergoing profound changes that shape the conditions of knowledge production and the way research is communicated, prompting a lively debate on how the various activities of those involved can be adequately acknowledged in publications. This contribution aims to empirically examine the relationship between authorship regulations in journal policies, the disciplinary variance in authorship practice and larger concepts of academic authorship. Analyzing (1) editorial policies and (2) data from an interdisciplinary survey of scientists, we examine to what extent disciplinary variances are reflected in the policies as well as in researchers' individual understandings. Here we find that the regulation of authorship qua policies is primarily effected at the level of the publishers. Although considerable disciplinary variations of journal policies are sometimes suggested in the literature, we find only minor differences in authorship criteria. The survey data however show that researchers' understandings of authorship exhibit significant, discipline-specific differences, as well as differences related to the characteristics of the research practice. It hence becomes clear that discipline-specific conditions of knowledge production with the resulting differences in authorship practices are hardly reflected in authorship policies. We conclude that the regulatory ambitions of authorship policies mostly focus on the prevention and elimination of deficits in the quality and integrity of scientific publications. Thus, it seems questionable whether authorship policies in their current form are suitable instruments for mediating between diverse authorship practices and normative ideals of legitimate authorship.
Crystal structure of human V-1 in the apo form
Authors: Takeda Shuichi , Koike Ryotaro , Nagae Takayuki , Fujiwara Ikuko , Narita Akihiro , Maéda Yuichiro , Ota Motonori 
Published: January 2021

V-1, also known as myotrophin, is a 13 kDa ankyrin-repeat protein that binds and inhibits the heterodimeric actin capping protein (CP), which is a key regulator of cytoskeletal actin dynamics. The crystal structure of V-1 in complex with CP revealed that V-1 recognizes CP via residues spanning several ankyrin repeats. Here, the crystal structure of human V-1 is reported in the absence of the specific ligand at 2.3 Å resolution. In the asymmetric unit, the crystal contains two V-1 monomers that exhibit nearly identical structures (Cα r.m.s.d. of 0.47 Å). The overall structures of the two apo V-1 chains are also highly similar to that of CP-bound V-1 (Cα r.m.s.d.s of <0.50 Å), indicating that CP does not induce a large conformational change in V-1. Detailed structural comparisons using the computational program All Atom Motion Tree revealed that CP binding can be accomplished by minor side-chain rearrangements of several residues. These findings are consistent with the known biological role of V-1, in which it globally inhibits CP in the cytoplasm.
Diagnostic potential of three serum microRNAs as biomarkers for equine sarcoid disease in horses and donkeys
Authors: Unger Lucia , Abril Carlos , Gerber Vinzenz , Jagannathan Vidhya , Koch Christoph , Hamza Eman 
Published: January 2021

AbstractBackgroundMicroRNAs (miRNAs) are potential biomarkers for equine sarcoids (ES).ObjectivesTo assess eca‐miR‐331, eca‐miR‐100, and eca‐miR‐1 as serum biomarkers for ES disease.AnimalsSixty‐eight ES cases (56 horses, 12 donkeys), 69 tumor‐free controls (60 horses, 9 donkeys), and 20 horses with other skin tumors.MethodsFor this case‐control study, expression of serum eca‐miR‐331, eca‐miR‐100, and eca‐miR‐1 in ES‐affected equids was compared to tumor‐free age‐, sex‐, and breed‐matched control horses and donkeys with other skin tumors using reverse transcription quantitative PCR (polymerase chain reaction) for relative miRNA quantification. Biological, preanalytical, and clinical variable influences on miRNA expression were examined. Receiver operator characteristic (ROC) curve analyses were used to determine differences in miRNA expression between groups.ResultsThe expression of eca‐miR‐100 was affected by age (P = .003) and expression of eca‐miR‐100 and eca‐miR‐1 were affected by hemolysis (both P < .001). Eca‐miR‐331 was unaffected by biological variation, hemolysis, ES type, and disease severity. Eca‐miR‐331 concentrations were higher in ES‐affected compared to tumor‐free controls (P = .002). The ROC curve analysis indicated an area under the curve of 0.65 (P = .002) with a sensitivity of 60%, specificity of 71%, and positive and negative likelihood ratios of 2.1 and 0.56, respectively, to diagnose ES. Eca‐miR‐331 expression did not discriminate between horses with ES and other skin tumors. Expression of eca‐miR‐100 and eca‐miR‐1 was not different between groups.Conclusions and Clinical ImportanceSerum eca‐miR‐331 expression is neither sensitive nor specific enough as a single ES biomarker. If combined with other miRNAs, it may be helpful for ES diagnosis.
Sleep interventions for adults admitted to psychiatric inpatient settings: a scoping review protocol
Authors: Aboaja Anne , Perry Amanda E. , Steele Rachel , Dewa Lindsay H. , Carey Jon F. , Clarbour Jane , Shah Shivali , Cairney Scott A. 
Published: January 2021

ABSTRACT

Objective:
The scoping review aims to identify how sleep is measured and what sleep interventions are used effectively in psychiatric inpatient settings. Potential barriers to measuring sleep in inpatient settings will be classified.

Introduction:
Polysomnography has shown that poor sleep is associated with emotional, cognitive, and somatic changes, as well as increased risks in suicide ideation and aggression. People with mental illness often experience sleep disturbances and believe the psychiatric inpatient environment contributes to sleep problems. The use of sleep interventions has been studied widely in general inpatient wards; less is known of similar interventions in psychiatric inpatient settings.

Inclusion criteria:
The review will include studies that focus on the effectiveness of sleep interventions for adults in any psychiatric inpatient setting. Studies that focus solely on sleep apnea, parasomnias, or restless legs syndrome will be excluded.

Methods:
A literature search of PsycINFO, Web of Science, MEDLINE, and Google Scholar will be conducted. Studies identified will be screened and examined against the eligibility criteria. Only studies published in English will be considered, and there will be no date limitation applied to the search. Eligible studies will be assessed for risk of bias and relevant data will be extracted to answer the review questions. Extracted data will be presented in narrative and tabular formats.
Clinical management of acute low back pain in elite and subelite rowers: a Delphi study of experienced and expert clinicians
Authors: Wilkie Kellie , Thornton Jane S , Vinther Anders , Trease Larissa , McDonnell Sarah-Jane , Wilson Fiona 
Published: January 2021

ObjectivesRowing-related low back pain (LBP) is common but published management research is lacking. This study aims to establish assessment and management behaviours and beliefs of experienced and expert clinicians when elite and subelite rowers present with an acute episode of LBP; second, to investigate how management differs for developing and masters rowers. This original research is intended to be used to develop rowing-related LBP management guidelines.MethodsA three-round Delphi survey was used. Experienced clinicians participated in an internet-based survey (round 1), answering open-ended questions about assessment and management of rowing-related LBP. Statements were generated from the survey for expert clinicians to rate (round 2) and rerate (round 3). Consensus was gained when agreement reached a mean of 7 out of 10 and disagreement was 2 SD or less.ResultsThirty-one experienced clinicians participated in round 1. Thirteen of 20 invited expert clinicians responded to round 2 (response rate 65%) and 12 of the 13 participated in round 3 (response rate 92%).One hundred and fifty-three of 215 statements (71%) relating to the management of LBP in elite and subelite rowers acquired consensus status. Four of six statements (67%) concerning developing rowers and two of four (50%) concerning masters rowers gained consensus.ConclusionIn the absence of established evidence, these consensus-derived statements are imperative to inform the development of guidelines for the assessment and management of rowing-related LBP. Findings broadly reflect adult LBP guidelines with specific differences. Future research is needed to strengthen specific recommendations and develop best practice guidelines in this athletic population.