bluuebunny/crossref_metadata_2025_split huggingface dataset:
Science-fiction et traduction en Chine continentale : d’outils pour le progrès à outils de soft power
Authors: Aloisio Loïc 
Published: December 2024

Cet article se propose de mettre en lumière, en s’appuyant tout d’abord sur la théorie du polysystème puis sur la notion de patronage de Lefevere, le rôle qu’a joué la traduction, premièrement dans la popularisation du genre en Chine continentale, son évolution et sa définition, afin d’explorer comment un genre « importé » a été continuellement remanié et mis en avant à chaque époque ; et dans un second temps, en tant qu’outil permettant de « réexporter » le genre, désormais plutôt bien assimilé, de la Chine populaire vers l’étranger, avec la mise en avant par le gouvernement chinois de la science-fiction comme outil de soft power voué à conter les « lendemains radieux » du pays.
South African parents’ views on oral, signing, and bilingual communication for Deaf or hard-of-hearing children
Authors: Khoza-Shangase Katijah , Bent Jasmine 
Published: December 2024

Background: Parents of Deaf or hard-of-hearing (DHH) children are faced with a plethora of overwhelming decisions concerning their children, particularly during the early stages of development. Among these decisions are those concerning assistive devices and the modes of communication for their child.Objectives: The aim of this study was to explore the perceptions of parents of DHH children towards the various modes of communication for their children within the South African context.Method: The study adopted a Q-methodology research design. Participants rated statements according to what they least and most agree with and then answered follow-up questions concerning the statements. Participants were also invited to participate in a live, one-on-one, semi-structured interview with the researcher. Data were analysed through both qualitative and quantitative statistics. Thematic analysis was adopted to analyse the qualitative data, while factor analysis through Ken-Q analysis was used for quantitative data.Results: Although 66% of participants thought that sign language allows DHH children to communicate more freely, 88% agreed that a DHH child should always learn to speak if they can. In terms of decision-making, 88% reported the issue of stigma or marginalisation and 88% cited the lack of Deaf schools as barriers in their decision-making.Conclusion: The study’s findings provide valuable insights into the complex interplay of factors influencing communication mode decisions for DHH children in South Africa.Contribution: These insights are crucial for developing inclusive and effective communication strategies that consider individual needs, societal norms and access to support services.
Contemporary theological approaches in Zimbabwe: Navigating the challenges of the 21st century
Authors: Baloyi Ezekiel 
Published: December 2024

The challenges of the 21st century are examined as Zimbabwe’s modern theological views are discussed, and responses are given and analysed in this study. In Zimbabwe, theology is changing quickly to meet the demands of the country’s people in the face of persistent socioeconomic difficulties, political unrest and cultural changes. Contemporary theological debate is structured by the historical background of Zimbabwean theology, which is characterised by colonial influences and the freedom movement. These days, the discussion tackles several urgent issues: gender justice, seen through the prism of feminist theology that seeks to demolish patriarchal structures; political unrest, highlighted by a prophetic theology that challenges corruption and fosters governance; the ongoing economic crisis, arguing for economic justice and ethical leadership; and the significance of interfaith dialogue and cultural integration in a pluralistic society. This study also emphasises how important it is to address the specific issues that young people face, include contemporary digital platforms in religious activities, and involve them in theological conversation. To make theology relevant and transformational, theological views in modern Zimbabwe are distinguished by their receptivity to regional and global shifts. This study makes an overview and analysis of theological responses in Zimbabwe – the case for a theology that is both prophetic and practical one that offers long-term remedies for social change in addition to criticism.Contribution: This study examines contemporary theological approaches in Zimbabwe, highlighting the adaptation of theology to address issues such as gender justice, political integrity and economic crises. It advocates for a responsive and transformative role for the church in promoting societal change.
Graduate perceptions of their interprofessional practice: Lessons for undergraduate training
Authors: Müller Jana , Archer Elize , Couper Ian 
Published: December 2024

Background: Interprofessional education (IPE) during undergraduate training (UGT) is considered important for new graduates to collaborate inter-professionally. There are, however, well-documented workplace challenges that hinder their involvement in interprofessional collaborative practice (IPCP) such as professional hierarchy, poor role clarification and communication challenges.Aim: This article explores graduates’ perceptions of the value rural undergraduate IPE had on their IPCP during their first year of work.Setting: Graduates were based in seven different provinces of South Africa ranging from tertiary-level institutions to community day clinics.Methods: A qualitative case study was conducted with 16 first-year graduate participants from 5 different health professions who participated in undergraduate IPE while placed on a rural platform. Individual semi-structured interviews were conducted in 2023.Results: Key factors related to UGT that facilitated IPCP during graduates’ first year of work were interprofessional relationship development, practice-based IPE and the focus on holistic patient-centred care. Graduates were, however, challenged by self-doubt, communication barriers and hierarchy in the workplace. Their recommendations for undergraduate IPE included role modelled and contextually relevant interprofessional skills development, practical advocacy and communication training, longer placements or shared learning spaces.Conclusion: Findings indicate that IPE during undergraduate rural clinical placements promotes interprofessional relationship development that extends into the workplace after graduation. However, IPE must be role modelled in the clinical environment and aligned to the reality of the healthcare system for students to develop the skills required to navigate IPCP as graduates.Contribution: This article offers recommendations for responsive undergraduate IPE to promote IPCP after graduation.
Evaluation of antifungal effect of amphotericin B in comparison with nystatin on Candida species derived from patients undergoing head-and-neck radiotherapy
Authors: Golestannejad Zahra , Saberi Zahra , Jamshidi Mina , Dehghan Parvin , Khozeimeh Faezeh , Faghihian Elham , Najafizadeh Nadia , Maheronnaghsh Mehrnoush , Chermahini Ahmad Amiri 
Published: December 2024

ABSTRACT

Background:
There is ample evidence showing the development of nystatin-resistant strains in patients undergoing malignancy treatment. Amphotericin B is a polyene antifungal drug that combines with ergosterol to cause cell death and is more effective on fungal species than routine antifungals such as nystatin. This study aimed to compare the effect of nystatin and amphotericin B on fungal species isolated from patients before and during head-and-neck radiotherapy.

Materials and Methods:
This in vitro experimental study was performed on samples isolated from patients undergoing head-and-neck radiotherapy before and during radiotherapy at Sayed al-Shohada Hospital in Isfahan, Iran. The isolates were identified by polymerase chain reaction-restriction fragment length polymorphism. Antifungal effects were determined by the microdilution method based on clinical and laboratory standards institute standards and minimum inhibitory concentration (MIC), minimum lethal concentration (MFC), drug sensitivity, and resistance were measured. The data were analyzed by SPSS version 22 (level of significance: 0.05).

Results:
Before radiotherapy, all albicans strains were sensitive to nystatin, whereas 71.4% were sensitive to amphotericin B. After radiotherapy, Candida albicans strains were 100% sensitive to nystatin and 75% sensitive to amphotericin B.

Conclusion:
The present study showed that before radiotherapy, all species isolated from patients, including C. albicans, C. tropicalis, and C. glabrata, were sensitive to nystatin, whereas a percentage of albicans species showed resistance to amphotericin B. In the 2nd week of radiotherapy, the same as before radiotherapy, all species isolated from patients were sensitive to nystatin, whereas a percentage of albicans species showed resistance to amphotericin B. In general, the current study showed that before and after radiotherapy, the antifungal effect of nystatin is greater than amphotericin B.
Antifungal effect of atorvastatin in comparison with fluconazole on Candida species isolated from patients undergoing head-and-neck radiotherapy
Authors: Golestannejad Zahra , Dehghan Parvin , Najafizade Nadia , Kheirkhah Mahnaz , Bafrani Maryam Emami , Tabesh Adel , Nadian Farshad , Khozeimeh Faezeh 
Published: December 2024

ABSTRACT

Background:
Head-and-neck radiotherapy can change oral Candida species and lead to the development of refractory oral candidiasis resistant to the commonly prescribed antifungal medications such as fluconazole. Atorvastatin exerts an antifungal effect by inhibiting the synthesis of fungal wall ergosterol and impairing mitochondrial function. This study aimed to compare the antifungal effects of fluconazole and atorvastatin on Candida species isolated from patients undergoing head-and-neck radiotherapy.

Materials and Methods:
In this clinical in vitro study, swab samples were collected from 33 patients admitted to Isfahan Seyed-O-Shohada Hospital before the onset and 2 weeks after the initiation of radiotherapy. The antifungal effects of fluconazole and atorvastatin were evaluated by the microdilution test according to the Clinical and Laboratory Standards Institute standards, and measuring their minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC). Data were analyzed by the Mann–Whitney U-test and the statistical significance level was considered P < 0.05.

Results:
The results showed that the MIC24, MIC48, and MFC of fluconazole were significantly lower than those of atorvastatin for Candida albicans, Candida tropicalis, and Candida glabrata both before (P < 0.001 for all) and during (P < 0.001 to P = 0.003) radiotherapy.

Conclusion:
According to the results, fluconazole has antifungal effects comparable to those of atorvastatin, but in much lower doses. Atorvastatin showed optimal antifungal effects but in doses beyond the clinically applicable threshold.
Pediatric Psoriasis: A Comprehensive Review with a Focus on the Latest Therapeutic Updates
Authors: Relhan Vineet , Kaur Aneet , Priyadharshini B. V. 
Published: December 2024

Abstract
Psoriasis is a common inflammatory disease with varied presentation ranging from papulosquamous plaques to generalized pustules. Children are also affected by this condition and it has a considerable psychological impact on both patients and their parents. There are some differences in clinical presentation and management in children when compared to adults which should be taken into account. Also, children suffering from psoriasis are at a higher risk of having metabolic syndrome as compared to the normal population, which demands screening for the same. The incidence of pediatric psoriasis is on the rise and it is crucial to make a correct diagnosis to ensure proper management. There are few studies on the management of pediatric psoriasis and the treatment guidelines are largely extrapolated from studies conducted in adults or the use of drugs for different clinical conditions in pediatric patients. In recent past, many new topical and systemic therapies have been approved for the treatment of pediatric psoriasis. In this review article, we discuss the prevalence, etiopathogenesis, clinical features, and management of pediatric psoriasis.
Youngest Encounter with Gorlin–Goltz Syndrome: Navigating Early Diagnosis and Management
Authors: Vijayakumar Adarsh , Philip Rashmi Mary , Criton Sebastian 
Published: December 2024

Abstract
Gorlin–Goltz syndrome is a rare autosomal dominant disorder caused by an inactivating mutation of the patched 1 gene. Patients could present as early as infancy with varied presentation and multiple basal cell carcinoma. This case report highlights the youngest reported case to date, a 5-month-old patient, who presented with multiple asymptomatic black papules and dysmorphic features. Dermatoscopy and subsequent investigations including targeted gene sequencing confirmed the diagnosis. This case underscores the importance of early recognition and multidisciplinary approach to the management of Gorlin–Goltz syndrome.
Comparison of the Efficacy and Safety of Levocetirizine versus Bilastine for the Treatment of Chronic Spontaneous Urticaria in the Pediatric Population: An Observer-blinded Randomized Control Trial
Authors: Sahoo Debashree , Panda Maitreyee , Jena Ajaya Kumar , Panda Anil Kumar 
Published: December 2024

Abstract

Background:
Chronic spontaneous urticaria (CSU) refers to urticaria that has no specific cause or trigger, present on most days of the week for 6 weeks or more. The incidence of chronic urticaria in the pediatric age group is between 0.1% and 3%. Levocetirizine and bilastine are nonsedative second-generation antihistamines used to treat urticaria in both adults and children.

Objective:
The primary objective was to compare the effectiveness of levocetirizine and bilastine in cases of pediatric CSU using Urticaria Activity Score (UAS) and Urticaria Severity Score (USS). The secondary objective was to evaluate and compare the safety and quality of life (QoL) using the Dermatology Life Quality Index (DLQI) score.

Materials and Methods:
This was a randomized, observer-blinded study where 65 patients (6–16 years) with a history of urticaria >6 weeks were divided into two groups with computer-generated randomization. Thirty-two patients were included in Group A, who received levocetirizine, and 33 patients were included in Group B, who received bilastine. UAS7, USS, and DLQI were recorded at every visit. The primary outcome was measured using UAS and USS and the secondary outcome in the form of patient’s QoL was assessed using the DLQI score. Laboratory parameters were assessed at the first visit and at the end of 3 months.

Results:
There was a significant difference (P = 0.002) in UAS7, USS, and DLQI between the baseline and last visit scores for each group. There was no significant difference (P = 0.28) in the scores between the two groups. Laboratory parameters like liver enzymes and complete blood count also did not show any significant differences between the two groups.

Conclusion:
Both levocetirizine and bilastine are equally effective and safe in the treatment of CSU at the end of 3 months. However, bilastine showed a better fall in the DLQI as compared to levocetirizine.
The potential use of medicinal plant extracts/products in the prevention of SARS-CoV2 infection and associated pathologies in the experimental models
Authors: Rizvi Zaigham Abbas , Awasthi Amit , Dikshit Madhu 
Published: December 2024

Abstract
Medicinal herbal extracts/products have been traditionally used in Asia, especially India and China, for many inflammatory and infectious disease conditions. Herbal extracts were also taken as adjunct therapy during coronavirus disease 2019 (COVID-19), with many in vitro and in silico studies suggesting their beneficial effects. In the current study, 11 selected herbal extracts/products were evaluated in an in vivo animal model to understand their protective efficacy and immunomodulatory potential. Data from the study suggest that Withania somnifera (L.) Dunal, Glycyrrhiza glabra L., Alstonia scholaris (L.) R. Br., and Picrorhiza kurroa Royle ex Benth showed promising antiviral activity as well as immunomodulatory properties. They were able to reduce the lung viral load and pulmonary pathology significantly, while Caesalpinia crista and Ayush-64 had significant anti-inflammatory potential but were unable to reduce the lung viral load significantly. The study provides scientific evidence for the protective efficacy of herbal extracts/products against COVID-19 based on animal protective efficacy data.
Morphometric analysis of internal auditory canal using CT imaging: An observational study in South Indian adult population
Authors: Sheryl Judica , Kannappan Senthil Ganesh P. 
Published: December 2024

Abstract

Background:
The posterior surface of the petrous part of the temporal bone, located near the anterolateral wall of the posterior cranial fossa, houses the internal auditory canal (IAC). The lateral fundus of this canal is divided into three distinct openings that accommodate the facial, cochlear, and vestibular nerves. The present study attempts to measure the dimensions of the IAC using digital image processing to understand how anatomical variations may aid in surgical planning.

Materials and Methods:
A morphometric analysis of the IAC was conducted at Saveetha Medical College and Hospital in Chennai, Tamil Nadu, India, from November 2021 to May 2022. The study included subjects aged between 25 and 86 years who underwent temporal computed tomography (CT) scans revealing characteristics of the IAC. Imaging was obtained from the supraorbitomeatal plane with the subjects in a designated head support position. The scans were performed using a Philips Secura™ 128-slice Ingenuity CT scanner. The study measured the IAC opening width (OW), longitudinal length (LL), and anteroposterior (AP) diameter in both male and female subjects.

Results:
Of the 70 cases included in the study, 27 were female, and 43 were male. Three distinct shapes of the IAC were identified across both genders: cylindrical, funnel-shaped, and bud-shaped. Among the 70 samples, 30 exhibited a cylindrical shape, 29 were funnel-shaped, and 11 were bud-shaped. The mean width of the IAC (OW) for both male and female subjects was 0.77 ± 0.19. The mean LL was 1.08 ± 0.20 in males and 1.02 ± 0.21 in females. The mean AP diameter was 0.44 ± 0.13 in males and 0.40 ± 0.13 in females.

Conclusion:
A detailed understanding of the anatomy and spatial relationships within the IAC is critical for diagnosing and treating conditions affecting this region. This space’s frequent vestibular schwannomas (auditory neuromas) underscores the canal’s clinical significance.
An investigation of birth preparedness and complication readiness and its implication in reducing childbirth mortality in Nigeria
Authors: Aniekan Peter Theresa , Aturaka Samson Olusegun , Eric Yila , Sanni Olaniyi Felix , Christiana Adeforiti Ebiyemi , Augusta Ozor Nneka , Modupe Abiola Agatha , Olubukola Popoola Temitope , Saidi Modupe Ireti 
Published: December 2024

Abstract

Background:
Maternal mortality poses a significant threat to mothers, their children, and families, prompting pregnant women to seek safe and effective deliveries. Nigeria ranks second globally in maternal mortality rates, highlighting the urgent nature of this issue. To address this, the United Nations supports birth preparedness and complication readiness (BPCR) to lower mortality rates and promote safer childbirth. This study evaluates BPCR practices among antenatal clinic attendees in Nigeria as part of ongoing efforts to reduce maternal and infant mortality.

Materials and Methods:
A descriptive cross-sectional survey was employed using a structured questionnaire. A total sample of 320 participants was calculated using a population-based random sampling formula, with 40 pregnant women selected from each of the eight clinics in the Iseyin Local Government Area. Data were analyzed using the IBM Statistical Package for the Social Sciences version 25.0 (Chicago, IL, USA), employing descriptive and inferential statistics at a 0.05 significance level. Results were presented through tables and charts.

Results:
The findings indicated that most respondents (86.8%) demonstrated a strong understanding of BPCR, while 87.8% reported good BPCR practices. A significant relationship (P < 0.05) was also observed between respondents’ knowledge, parity, and BPCR practices.

Conclusion:
The study highlights that sociodemographic factors, gravidity, parity, and BPCR knowledge significantly influence birth preparedness among pregnant women in Iseyin, Nigeria. Younger, first-time mothers and those with greater BPCR knowledge showed better preparedness. While most participants practiced essential BPCR measures, challenges such as unsafe abortions, limited antenatal care, and poverty still contribute to perinatal mortality. Addressing these gaps through targeted education and resource access could further reduce childbirth-related mortality.
A study of the histopathological spectrum of thyroid neoplasms in a tertiary health care center
Authors: Siddiqui Rabia Parveen , Bhaskar Vanita , Swami Kavita , Pandey Varsha , Chandrakar Anubhav , Mangrulkar Kasturi 
Published: December 2024

Abstract

Background:
Thyroid gland lesions are common and can result from systemic conditions such as Graves’ disease or localized abnormalities like nodular enlargement or tumors. Thyroid malignancies are the most prevalent endocrine cancers, accounting for approximately 92% of all endocrine malignancies. This study aims to explore the spectrum of thyroid neoplasms in a tertiary healthcare center.

Aims and Objectives:
The primary objective of this study was to examine the histopathological spectrum of thyroid neoplasms in a tertiary healthcare center. Additionally, the study aims to assess the frequency of various thyroid neoplasms across different age groups and genders and to identify any associated nonneoplastic thyroid lesions that occur alongside thyroid neoplasms.

Materials and Methods:
This observational descriptive cross-sectional study was conducted in the Department of Pathology, Pt. Jawahar Lal Nehru Memorial Medical College, Raipur, Chhattisgarh, India, over 50 months from January 2020 to March 2024. A total of 71 cases meeting the inclusion criteria were analyzed.

Results:
Of the 71 thyroid specimens examined, 12 cases (16.9%) were benign, whereas 59 cases (83.09%) were malignant. The study demonstrated a significant female predominance with a female-to-male ratio of 9.1:1 (64 females and 7 males). Most cases were observed in the 21–30 years age group, with a mean age of 32.3 years. Papillary carcinoma was identified as the most common malignant lesion, accounting for 35 cases (52.1%), whereas follicular adenoma was the most common benign lesion, accounting for 9 cases (12.7%).

Conclusion:
Accurate diagnosis of thyroid malignancies requires a combination of clinical history, radiological imaging, thyroid function tests, and thorough histopathological examination. Early and proper diagnosis facilitates more effective treatment decisions, standardized management protocols, and improved patient outcomes.