bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative study between the efficacy of topical sildenafil and topical minoxidil in the treatment of male androgenic alopecia
Authors: Al-Shabkhon Ali Abdulkareem , Halim Emam Adel Ahmed , Abd Elfattah Afify Ahmed 
Published: October 2021

Abstract

Background
Androgenic alopecia is the most common form of alopecia in men and women. Its incidence increase with age, many treatment modalities are available but results are variable. Androgenetic alopecia is a hereditary thinning of the hair induced by androgens in genetically susceptible men and women. Also known as male-pattern hair loss or common baldness in men and female-pattern hair loss in women. Thinning of hair usually begins between 12 and 40 years old in males and females. Inheritance is polygenic.

Aim of the study
To evaluate and compare the efficacy, safety and side effects of topical sildenafil and topical minoxidil in the treatment of androgenic alopecia

Patients and methods
This exploratory pilot study included 30 male patients suffering from androgenic alopecia. Included patients were divided into 2 equal groups based on treatment received; one group received 1% topical sildenafil and the other group received 55 topical minoxidil. Assessment of treatment response was done using trichoscopy.

Results
Sildenafil treated group showed statistically significant increase in VH and TH count at 18 cm point, 24 cm point after treatment compared to before treatment. While, temporal side showed statistically significant increase in VH only. minoxidil treated group showed statistically significant increase in TH count, T/V hair ratio and hair thickness at 18 cm point and temporal side after treatment compared to before treatment. VH count was significantly decreased after treatment compared to before treatment at 18 cm point. At 24 cm point, only TH was significantly increased after treatment compared to before treatment.
Comparison between the Efficacy of Intense Pulsed Light (IPL) versus Photodynamic Therapy with Methylene Blue in the Treatment of Nail Psoriasis
Authors: Shaheen Maha Adel , Hassen Samah Ibrahim , Omar Dakhli Azzahra 
Published: October 2021

Abstract

Background
Nail psoriasis is often refractory to traditional treatments, and patients with nail psoriasis usually demand a therapeutic option. Both photodynamic therapy (PDT) and intense pulsed light have been evaluated in nail psoriasis.

Objective
The objective of this study was to evaluate and compare the efficacy of IPL and methylene blue assisted photodynamic therapy in the treatment of nail psoriasis.

Patients and Methods
Twenty patients (15 males and 5 females) with mild to moderate psoriasis with nail affection were included in this study. Their age ranged from 24 to 71 years. The PDT used IPL as the light source and methylene blue as photosensitizer. Sessions were applied every 2 weeks for a maximum of 3 months, treating one hand with IPL and the other with PDT. The nails treated were evaluated at baseline, after 2 sessions, after 6 sessions and 3 months after the last treatment session according to the Nail Psoriasis Severity Index (NAPSI) score. Follow-up was performed after 2 sessions, after 6 sessions, and 3 months after the last treatment session.

Results
A decrease in NAPSI score was observed with both treatments and in both nail bed and nail matrix involvement. No statistically significant difference was found between PDT and IPL as regarding total NPASI score. However, total NAPSI score improved by 61% in MB-PDT group versus 47% in IPL group. Patient follow-up revealed the appearance of new lesions in 3 patients in the group of IPL, and in 1 patient in the MB-PDT after 6 months.

Conclusion
Intense pulsed light and methylene blue assisted PDT are a promising effective modalities of treatment of nail psoriasis, which are easy to use, safe, and nearly pain-free. This was confirmed by the improvement NAPSI score.
Intralesional Zinc Sulfate 2% Vs Intralesional Vitamin D In The Treatment Of Planter Warts
Authors: Saber Fatma 
Published: October 2021

Abstract

Background
verrucae are benign proliferations seen in skin and mucosae due to infection with papillomaviruses.

Aim and Objectives
the aim of this work is to compare the clinical efficacy of intra-lesional 2% zinc sulfate solution vs intralesional vitamin D in the treatment of planter warts,

Subjects and Methods
this is Three armed single blinded randomized clinical trial included 105 patients presented with planter warts, Patients were all recruited from the Dermatology outpatient clinic at Ain-Shams University Hospital and Almateria hospital during the period From July 2018 to July 2019, Patients included in the present study were divided into 3 groups, 35 patients per group by simple randomization process which could allocate patients to either of three arms randomly and each patient would have an equal chance to be allocated to either of the three arms,

Results
There was no statistically significant difference between the 3 studied groups as regard the response to treatment after 1st, 2nd and 4th session. While after the 3rd session, there was statistically significant increase in the numbers of partial responders in the 3 studied groups (P = 0.023),

Conclusion
the current study showed that intralesional injection of 2% zinc sulfate is a better therapeutic option in the treatment of planter warts in comparison with intralesional vit D,
Clinical, Trichoscopic And Immunohistochemical Evaluation of Autologous Adipose Derived Adult Stem Cell Injection in the Treatment of Female Pattern Hair Loss
Authors: Moneib Hoda Ahmed , Mohamed Ghada Fathy , Ahmed Naglaa Samir , El-Sayed Abou-Noor Mahy El-Bassiouny 
Published: October 2021

Abstract

Background
Cellular and cell-derived components of adipose-derived tissue for the purposes of dermatologic and aesthetic rejuvenation applications have become increasingly studied and integrated into clinical practice. The hair follicle goes through phases of growth, regression, and quiescence, and it is suspected that adipocytes secrete factors to promote activation of hair follicles dermal papilla cells, increasing migration, and proliferation in vitro; as well as increasing conversion of hair follicles from the telogen to anagen phase in vivo.

Objectives
Evaluation of efficacy and safety of adipose-derived adult stem cells (ADSCs) injection in hair follicle regeneration in female pattern hair loss (FPHL).

Methods
33 patients were included and divided into 3 groups according to Sinclair’s classification according to severity. ADSCs were extracted from lipoaspirate and injected into the frontoparietal scalp. Patients were assessed clinically, trichoscopically and immunohistochemically.

Results
At week 24, there was improvement of hair thickness and count, both in frontal and occipital areas. Histopathological and immunohistochemical assessment at week 12 showed decrease of perifollicular inflammation and decrease of DKK-1 immunostaining.

Conclusion
The use of ADSCs in treatment of FPHL in subjects included in this study showed improvement of perifollicular inflammation, in addition to density and thickness of hair.
Evaluation of the efficacy and safety of different dilutions of Mesobotox in Mid and / or lower face rejuvenation: Interventional study
Authors: El Rahman Nesma Saber Abd , Abdallah Salem Samar , Elfattah Afify Ahmed Abd , Mohamed Seoudy Wael 
Published: October 2021

Abstract
As life expectancy has prolonged nowadays, interest has increased to change patterns of life, which include improving the consequences of skin ageing through slowing the ageing process. There are two main processes of skin ageing either intrinsic or extrinsic. Intrinsic ageing reflects genetic background in which skin appears thin with exaggerated expression lines. However, extrinsic ageing is caused by external factors such as smoking, excessive use of alcohol, poor nutrition and sun exposure. Extrinsically aged skin appears predominantly not only by wrinkles, but also by pigmented lesions such as freckles, lentigines and patchy hyperpigmentation, and depigmented lesions such as guttate hypomelanosis. Epidermal and dermal atrophy, rough skin texture, flushing, erythema, telangiectasias, dilated pores and loss of tone and elasticity are also other signs of skin aging.
Over the past few years, the use of Mesobotox has broadened and it is now commonly used as rejuvenation procedure with different dilutions. Our work aimed to compare between three commonly used dilutions of Mesobotox regarding its efficacy and safety, as this comparison was not done previously.

Aim of the study
The aim of this work is to evaluate and compare between different dilutions of Mesobotox in mid and / or lower facial rejuvenation.

Patients and methods
We included 30 patients complaining of facial wrinkles. Patients were divided into three equal groups to study three different dilutions of Mesobotox 1:5, 1:7 and 1:10. Assessment of treatment response was done using 3D Antera camera.

Results
Assessment of treatment response using Antera camera in 1:5 dilution revealed statistically significant improvement in all the parameters (periorbital and midface) with more evident improvement after 1 month of treatment compared to after 6 months of treatment. With 1:7 dilution and 1:10 dilution, response revealed statistically significant improvement in most of the parameters (periorbital and midface) with more evident improvement after 1 month of treatment compared to after 6 months of treatment.
Treatment of Striae Alba using Fractional Radiofrequency with and without Lyophilized Growth Factors
Authors: Abdallah Marwa M. A , Abd Elfattah Afify Ahmed , Hussain Ali Al-Rubaiay Nuha 
Published: October 2021

Abstract

Background
Various treatment modalities have been applied to treat striae alba with low satisfaction rate. Fractional Microneedling radiofrequency provides deep dermal coagulation, thereby inducing collagen synthesis and tissue tightening. The addition of platelet lyophilized growth factors may add to the effect of fractional Microneedling radiofrequency.

Objectives
To evaluate and compare the efficacy and safety of fractional Microneedling radiofrequency alone or combined with lyophilized growth factors in the treatment of striae alba.

Methods
In this left-right comparative study, 25 patients suffering from striae alba on the abdomen received sessions of fractional microneedling radiofrequency with lyophilized growth factors on one side and with saline (as placebo) on the other side at 4 weeks interval. Patients‘ satisfaction was evaluated at the end of study using a questionnaire (Patients were asked the following questions: Are you satisfied with this treatment (completely satisfied, satisfied, partially satisfied, or not satisfied)?.

Results
There was a significant improvement in striae alba after treatment in both the lyophilized growth factors (p = &lt;0.0001) and placebo sides (p = &lt;0.0001), the lyophilized growth factors being superior (p = 0.002). Patient satisfaction was more on the LGF side (p = 0.034),where 6 versus 3 patients were completely satisfied. Erythema and hyperpigmentation were less on the lyophilized growth factors side.

Conclusion
The combination of fractional microneedling radiofrequency and lyophilized growth factors improves striae alba outcome.
Comparative Study between the Efficacy of Platelet Rich Plasma with Methotrexate and Methotrexate Alone in Treatment of Chronic Plaque Psoriasis
Authors: El Sayed Mahira Hamdy , El Husseiny Rania Mahmoud , Abdellatif Ola Atef Ibrahim 
Published: October 2021

Abstract

Background
Psoriasis affects up to 3% of the world's population or more than 125 million people. There is an urgent need for new treatment strategy, as up to 50% of patients are not satisfied with current therapies. We evaluated the efficiency of combined platelet rich plasma (PRP) and methotrexate (MTX) injection in management of psoriasis vulgaris and combared it with methotrexate injection only.

Objectives
The aim of this work is to compare between the clinical efficacy of platelet rich plasma with methotrexate and methotrexate alone in treatment of chronic plaque psoriasis.

Patients and Methods
Forty patients with chronic plaque psoriasis were divided into two groups. Twenty patients were assigned into combinational treatment group (PRP + MTX) and monotherapy group (MTX alone) consisted of another tweenty patients. All patients in combinational therapy group received autologous intralesional PRP at 0,4 and 8 weeks combined with methotrethate im injection once every week for 12 weeks, while patients in monotherapy group received only methotrexate im injection once every week for 12 weeks.

Results
There were statistically significant decreased DLQI score after 6 and 12 weeks of treatment in females compared to males only in group B, while no significant differences were found between males and females in group A patients, This could be attributed to the greater concern in females as psoriasis is considered as a cosmotic problem.

Conclusion
Combination treatment of PRP with MTX is more effective than MTX alone in treatment of psoriasis vulgaris.
Nasal Steroids Use in the Prevention of Symptomatizing Adenoid Regrowth after Adenoidectomy
Authors: Ezzat Waleed F , Elczz Tamer A. Abo , Marouf Ahmed M , Ahmed Eman M 
Published: October 2021

Abstract

Background
Regrowth of the adenoids is a well-recognized entity. Intranasal steroids for children with adenoid vegetation can provide an alternative to revision surgery.

Objective
To assess the ol' using nasal steroids to prevent recurrence of adenoid hypertrophy and related symptoms after adenoidectomy.

Methods
Controlled clinical trial. One hundred patients after adenoidectomy were divided randomly into 2 groups. Group I were patients performing surgery on odd days of the month received postoperative intranasal steroid [fluticasone propionate (50 mcg/metered dose per nostril per day)] and Group Il were patients performing surgery on even days of the month received intranasal saline spray starting at postoperative week 2 after wound healing. Both medications will be adninistrated for 8 weeks postoperatively. Patients will be followed up for minimum of 6 months by using modified SNOT Score to suit children in reporting the degree of the symptoms and i!' needed nasopharyngeal lateral X-rays.

Results
Highly significant difference between both groups after 6 months postoperatively.

Conclusion
The use of intranasal steroids may obtain successful results in children to prevent adenoid regrowth and recurrence of related nasal symptoms after adenoidectomy. The most appropriate drug, the most efficient dose, and optimal treatment duration need to be investigated and determined.
Systematic Review of The Outcome of Different Modalities of Voice Rehabilitation Following Total Laryngectomy
Authors: Mohamed Ahmed Adly , Hamdy Tarek Abdel hamid , Askoura Anas Mohamed , Ghaly Mohamed Samir Ahmed Kamal Mohamed 
Published: October 2021

Abstract

Background
Speech impairment occurs in 34-70% of head and neck oncologic patients. Management of this impairment is through surgical and nonsurgical methods. Progress in voice rehabilitation following total laryngectomy has over the last 30 years, made an enormous difference in the whole concept of the management of laryngeal cancers.

Objective
To explore the outcome of different options of voice rehabilitation after total laryngectomy and the advantages and disadvantages of each method in order to improve the quality of life of laryngectomized patients and the suggestion of future directions for research.

Patients and Methods
The Aim of this work is to provide cumulative data about the efficacy and safety of the outcome of different modalities of voice rehabilitation following total laryngectomy. This review was done using standard methodology outlined in the Cochrane Handbook and reported the findings in accordance with the Preferred Reporting Items for Systematic Reviews and Metaanalyses (PRISMA) statement guidelines.

Results
Voice rehabilitation is one of the most important determinants of the quality of life after total laryngectomy. Recent advances in prosthetic voice devices have made such devices the gold standard for voice rehabilitation. They are thus preferred and used more often than old methods (esophageal speech and artificial larynx).

Conclusion
Although, no single method is considered to be the best for every patient, the tracheoesophageal puncture has become the most preferred method in the past decade. But it is not always possible in all patients, the results of this study indicate that ES, when achievable, is a viable option that should be considered by surgeons when making intervention decisions on patients, and should be revived when indicated. But we need much more studies.
Effect of using smart phones on balance functions
Authors: Hazzaa N , Hassan DM , Mahmoud Sh 
Published: October 2021

Abstract

Objective
To investigate the effect of visual fatigue caused by smart phone on the balance function.

Subjects and Methods
Forty subjects divided into 2 groups were included in the present study . Group I, twenty normal healthy subjects with mean age of 28.8 years. Group II, twenty subjects with a clinical diagnosis of peripheral vestibular disorder with mean age of 38.85years. They were subjected to a computer vision syndrome questionnaire (CVS-Q) , occulomotor tests of videonystagmography (VNG) and sensory organization test (SOT) of computerized dynamic posturography (CDP) before and after visual fatigue induction.

Results
Significant differences existed between C5, 6 and composite scores in group I and in C4 and composite scores in group II after visual fatigue induction. However, there was no significant difference between occulomotor tests in both groups after visual fatigue induction.

Conclusions
The smart phone use can affect the balance function in healthy subjects and augment the deficit in those with balance problem. Reducing visual fatigue should be considered through various procedures as taking proper rest, adjusting the brightness of screen, avoid any wrong posture and using filters if possible.
Impact of Urinary Incontinence on Physical Performance and Quality of Life (QOL) among a group of elderly in Cairo
Authors: El-gharib Alaa K , Manzour Ayat F , El-Mallah Reem , El Said Salma M.S 
Published: October 2021

Abstract

Background
Urinary incontinence (UI) is a common disorder that particularly affects the elderly population worldwide. UI can be associated with poor quality of life (QOL) of this vulnerable population, as it leads to the limitation of their physical and social activities of daily life. Additionally, it has a psychological and economic burden on individuals, health care services and society.

Objectives
This study was performed to measure the frequency of UI and to determine its impact on the overall QOL of elderly, physical performance and activities of daily living.

Participants and Methods
A cross-sectional study was performed on attending the four Primary Health Care centres (PHCs) of El-Obour City. Data collection was done in randomly chosen days every week. All elders aged 60 or above, who attended the PHCs those days, were included until a sample size of 150 elderly was obtained. The International Consultation of Incontinence (ICIQ) was used to detect urinary incontinence, assess its type and severity while, SF-12 was used to assess quality of life (QOL) with its mental and physical components. All study participants underwent short physical performance battery balance, gait and chair tests

Results
The overall frequency of UI was 38% among the studied elderly. UI ranged from mild (12.3%) to moderate (57.9%) and severe (29.8%). Among incontinent participants, the frequency in men was 47.4% and in women was 52.6%. The frequency of stress, urge, mixed and other UI were 7%, 33.3%, 40.4% and 19.3% respectively. Incontinent elderly had significantly lower QOL as regards mental and physical indices than their continent counterparts. UI severity was inversely related to physical performance.

Conclusion and recommendation
UI has a high-frequency rate among the elderly population, and it has a significant impact on all QOL domains as well as on their physical performance. It is recommended to set up management plans and strategies in geriatric health care facilities to prevent UI and its impact on the physical and mental health of this vulnerable population.
Efficacy of peritoneal dialysis on encephalopathic patient with Citrullinemia type I
Authors: Gamal Radwa , Khalifa Ola A 
Published: October 2021

Abstract

Citrullinemia type I (CTLN1) clinical spectrum includes an acute neonatal form ("classic" form) and a milder late-onset form (“non-classic" form). Infants with classic form appear normal at birth. Shortly thereafter, they experienced hyperammonemia and develops symptoms. Without prompt intervention, rapid neurological deterioration with seizures, spasticity, loss of consciousness and even death can occur. Continuous venovenous hemofiltration should be started in neonates and children with ammonia levels &gt; 500 µmol/L or even at lower levels if there has been an inadequate response to medical management after 4 hours. Alternatively, but only in centers that lack ability or expertise to perform extracorporeal therapy, peritoneal dialysis can be utilized. The hallmarks of dialysis is rapid lowering of plasma ammonia concentration to avoid neurotoxicity and irreversible brain damage.

Objectives
To evaluate the effect of peritoneal dialysis on plasma ammonia levels and the clinical outcome in an encephalopathic Egyptian patient with CTLN1.

Patient and Methods
A 2.5 year old male patient with a classical form of CTLN1was recruited. The first presenting symptom of the patient was poor suckling and disturbed conscious level at the age of 5 day. He was admitted to neonatal intensive-care unit (NICU) with hyperammonemic encephalopathy and abnormal pattern of breathing. He developed apneic attack and underwent mechanical ventilation. The diagnosis of CTLN1 was established with elevated plasma ammonia concentration (350 µmol/L) and plasma citrulline concentration (2570 µmol/L). The patient was managed with peritoneal dialysis for 4 days, together with protein restriction, sodium benzoate, arginine therapy and high caloric intake.

Results
Plasma ammonia level was decreased with improvement of general condition and conscious level after dialysis. Upon discharge from NICU, the patient was referred to our Genetic clinic and no history of further hospital admission since then. Mild developmental delay mainly cognitive was noted during his regular clinic follow up.

Conclusion
CTLN1 can present with hyperammonemic encephalopathy which could be lethal if not promptly managed. Peritoneal dialysis proved to be an effective therapy of reducing plasma ammonia rapidly and improving outcome of the patient.