bluuebunny/crossref_metadata_2025_split huggingface dataset:
Information Seeding and Knowledge Production in Online Communities: Evidence from OpenStreetMap
Authors: Nagaraj Abhishek 
Published: January 2021

The wild success of a few online communities (such as Wikipedia) has obscured the fact that most attempts at forming such communities fail. This study evaluates information seeding, an early-stage intervention to bootstrap online communities that enables contributors to build on externally sourced information rather than have them start from scratch. I analyze the effects of information seeding on follow-on contributions using data on more than 350 million contributions made by more than 577,000 contributors to OpenStreetMap, a crowd-sourced map-making community seeded with data from the U.S. Census. I estimate the effect of seeding using a natural experiment in which an oversight caused about 60% of U.S. counties to be seeded with a complete census map, while the rest were seeded with less complete versions. Although access to basic knowledge generally encourages downstream knowledge production, I find that a higher level of information seeding significantly lowered follow-on contributions and contributor activity on OpenStreetMap, and was associated with lower levels of long-term quality. However, seeding did benefit densely populated urban areas and did not discourage more committed users. To explain these patterns, I argue that information seeding can crowd out contributors’ ability to develop ownership over baseline knowledge and thereby disincentivize follow-on contributions. This paper was accepted by Chris Forman, information systems.
The temporospatial epidemiology of rheumatic heart disease in Far North Queensland, tropical Australia 1997–2017; impact of socioeconomic status on disease burden, severity and access to care
Authors: Kang Katherine , Chau Ken W. T. , Howell Erin , Anderson Mellise , Smith Simon , Davis Tania J. , Starmer Greg , Hanson Josh 
Published: January 2021

Background
The incidence of rheumatic heart disease (RHD) among Indigenous Australians remains one of the highest in the world. Many studies have highlighted the relationship between the social determinants of health and RHD, but few have used registry data to link socioeconomic disadvantage to the delivery of patient care and long-term outcomes.

Methods
A retrospective study of individuals living with RHD in Far North Queensland (FNQ), Australia between 1997 and 2017. Patients were identified using the Queensland state RHD register. The Socio-Economic Indexes for Areas (SEIFA) Score–a measure of socioeconomic disadvantage–was correlated with RHD prevalence, disease severity and measures of RHD care.

Results
Of the 686 individuals, 622 (90.7%) were Indigenous Australians. RHD incidence increased in the region from 4.7/100,000/year in 1997 to 49.4/100,000/year in 2017 (p<0.001). In 2017, the prevalence of RHD was 12/1000 in the Indigenous population and 2/1000 in the non-Indigenous population (p<0.001). There was an inverse correlation between an area’s SEIFA score and its RHD prevalence (rho = -0.77, p = 0.005).
249 (36.2%) individuals in the cohort had 593 RHD-related hospitalisations; the number of RHD-related hospitalisations increased during the study period (p<0.001). In 2017, 293 (42.7%) patients met criteria for secondary prophylaxis, but only 73 (24.9%) had good adherence. Overall, 119/686 (17.3%) required valve surgery; the number of individuals having surgery increased over the study period (p = 0.02).
During the study 39/686 (5.7%) died. Non-Indigenous patients were more likely to die than Indigenous patients (9/64 (14%) versus 30/622 (5%), p = 0.002), but Indigenous patients died at a younger age (median (IQR): 52 (35–67) versus 73 (62–77) p = 0.013). RHD-related deaths occurred at a younger age in Indigenous individuals than non-Indigenous individuals (median (IQR) age: 29 (12–58) versus 77 (64–78), p = 0.007).

Conclusions
The incidence of RHD, RHD-related hospitalisations and RHD-related surgery continues to rise in FNQ. Whilst this is partly explained by increased disease recognition and improved delivery of care, the burden of RHD remains unacceptably high and is disproportionately borne by the socioeconomically disadvantaged Indigenous population.
Effect of physical activity on reducing the risk of diabetic retinopathy progression: 10-year prospective findings from the 45 and Up Study
Authors: Yan Xixi , Han Xiaotong , Wu Changfan , Shang Xianwen , Zhang Lei , He Mingguang 
Published: January 2021

ObjectiveTo examine the association of physical activities (PA) with diabetic retinopathy (DR) progression based on a 10-year follow-up of a large cohort of working-aged diabetic populations in Australia.MethodsNine thousand and eighteen working-aged diabetic patients were enrolled from the baseline of the 45 and Up Study from New South Wales, Australia. Self-reported PA collected by questionnaire at baseline in 2006 was graded into low (<5 sessions/week), medium (≥5–14), and high (≥14) levels. Retinal photocoagulation (RPC) treatment during the follow-up period was used as a surrogate for DR progression and was tracked through the Medicare Benefits Schedule, which was available from 2004 to 2016. Cox regression was used to estimate the association between PA and RPC incidence.ResultsIn the fully adjusted model, higher PA level was significantly associated with a lower risk of RPC incident (Cox-regression, p-value for trend = 0.002; medium vs. low, hazard ratio (HR) = 0.78, 95% Confidence Interval (CI): 0.61–0.98; high vs. low, HR = 0.61, 95%CI: 0.36–0.84. In addition, gender, body mass index, insulin treatment, family history of diabetes, history of cardiovascular disease were significant effect modifiers for the association between PA and RPC.ConclusionsHigher PA level was independently associated with a lower risk of DR progression among working-aged diabetic populations in this large cohort study.
Burden of disease and risk factors for mortality amongst hospitalized newborns in Nigeria and Kenya
Authors: Nabwera Helen M. , Wang Dingmei , Tongo Olukemi O. , Andang’o Pauline E. A. , Abdulkadir Isa , Ezeaka Chinyere V. , Ezenwa Beatrice N. , Fajolu Iretiola B. , Imam Zainab O. , Mwangome Martha K. , Umoru Dominic D. , Akindolire Abimbola E. , Otieno Walter , Nalwa Grace M. , Talbert Alison W. , Abubakar Ismaela , Embleton Nicholas D. , Allen Stephen J. ,   on behalf of the Neonatal Nutrition Network (NeoNuNet)
Published: January 2021

Objective
To describe the patient population, priority diseases and outcomes in newborns admitted <48 hours old to neonatal units in both Kenya and Nigeria.

Study design
In a network of seven secondary and tertiary level neonatal units in Nigeria and Kenya, we captured anonymised data on all admissions <48 hours of age over a 6-month period.

Results
2280 newborns were admitted. Mean birthweight was 2.3 kg (SD 0.9); 57.0% (1214/2128) infants were low birthweight (LBW; <2.5kg) and 22.6% (480/2128) were very LBW (VLBW; <1.5 kg). Median gestation was 36 weeks (interquartile range 32, 39) and 21.6% (483/2236) infants were very preterm (gestation <32 weeks). The most common morbidities were jaundice (987/2262, 43.6%), suspected sepsis (955/2280, 41.9%), respiratory conditions (817/2280, 35.8%) and birth asphyxia (547/2280, 24.0%). 18.7% (423/2262) newborns died; mortality was very high amongst VLBW (222/472, 47%) and very preterm infants (197/483, 40.8%). Factors independently associated with mortality were gestation <28 weeks (adjusted odds ratio 11.58; 95% confidence interval 4.73–28.39), VLBW (6.92; 4.06–11.79), congenital anomaly (4.93; 2.42–10.05), abdominal condition (2.86; 1.40–5.83), birth asphyxia (2.44; 1.52–3.92), respiratory condition (1.46; 1.08–2.28) and maternal antibiotics within 24 hours before or after birth (1.91; 1.28–2.85). Mortality was reduced if mothers received a partial (0.51; 0.28–0.93) or full treatment course (0.44; 0.21–0.92) of dexamethasone before preterm delivery.

Conclusion
Greater efforts are needed to address the very high burden of illnesses and mortality in hospitalized newborns in sub-Saharan Africa. Interventions need to address priority issues during pregnancy and delivery as well as in the newborn.
Assessment of clinical and microbiota responses to fecal microbial transplantation in adult horses with diarrhea
Authors: McKinney Caroline A. , Bedenice Daniela , Pacheco Ana P. , Oliveira Bruno C. M. , Paradis Mary-Rose , Mazan Melissa , Widmer Giovanni 
Published: January 2021

Background and aimsFecal microbial transplantation (FMT) is empirically implemented in horses with colitis to facilitate resolution of diarrhea. The purpose of this study was to assess FMT as a clinical treatment and modulator of fecal microbiota in hospitalized horses with colitis.MethodsA total of 22 horses with moderate to severe diarrhea, consistent with a diagnosis of colitis, were enrolled at two referral hospitals (L1: n = 12; L2: n = 10). FMT was performed in all 12 patients on 3 consecutive days at L1, while treatment at L2 consisted of standard care without FMT. Manure was collected once daily for 4 days from the rectum in all colitis horses, prior to FMT for horses at L1, and from each manure sample used for FMT. Fecal samples from 10 clinically healthy control horses housed at L2, and 30 healthy horses located at 5 barns in regional proximity to L1 were also obtained to characterize the regional healthy equine microbiome. All fecal microbiota were analyzed using 16S amplicon sequencing.Results and conclusionsAs expected, healthy horses at both locations showed a greater α-diversity and lower β-diversity compared to horses with colitis. The fecal microbiome of healthy horses clustered by location, with L1 horses showing a higher prevalence of Kiritimatiellaeota. Improved manure consistency (lower diarrhea score) was associated with a greater α-diversity in horses with colitis at both locations (L1: r = -0.385, P = 0.006; L2: r = -0.479, P = 0.002). Fecal transplant recipients demonstrated a greater overall reduction in diarrhea score (median: 4±3 grades), compared to untreated horses (median: 1.5±3 grades, P = 0.021), with a higher incidence in day-over-day improvement in diarrhea (22/36 (61%) vs. 10/28 (36%) instances, P = 0.011). When comparing microbiota of diseased horses at study conclusion to that of healthy controls, FMT-treated horses showed a lower mean UniFrac distance (0.53±0.27) than untreated horses (0.62±0.26, P<0.001), indicating greater normalization of the microbiome in FMT-treated patients.
Has loneliness and poor resilient coping influenced the magnitude of psychological distress among apparently healthy Indian adults during the lockdown? Evidence from a rapid online nation-wide cross-sectional survey
Authors: Lahiri Arista , Jha Sweety Suman , Acharya Rudraprasad , Dey Abhijit , Chakraborty Arup 
Published: January 2021

Background
The burden of psychological distress is increasing with the spread of the pandemic and also with the enforcement of its containment measures. The aim of this research was to determine the proportion of self-reported psychological distress, loneliness and degrees of resilient coping, and to also investigate the relationship of loneliness, coping and other variables with psychological distress among apparently healthy Indians during nation-wide lockdown period.

Methods
A cross-sectional, region-stratified survey using pre-designed pre-tested Google form disseminated via different social media platforms was conducted. A total of 1249 responses were analysed all over India. The form enquired about Socio-demographic profile, awareness on COVID pandemic and cases in the surroundings. UCLA Loneliness scale, Brief resilience and coping scale (BRCS) and Psychological distress scale (K6) assessed self-reported loneliness, coping and psychological distress, respectively. Special regressor technique adjusting for endogeneity and heteroskedasticity was used to extract the average marginal effects.

Results
Majority of the respondents were 18–35 years old, male, single and urban residents. News media, social media mostly acted as sources of information regarding COVID related news. Overall, 54.47% (95% CI: 51.39–57.53%) and 38.39% (95% CI: 35.57–41.29%) were reported to be lonely and had low resilient coping ability respectively. Around 44.68% had high risk of developing psychological distress. Being a student (average marginal effect coefficient (AMECoef).: -0.07, 95% CI: [-0.12, -0.01]) and perceiving lockdown as an effective measure (AMECoef: -0.11, 95% CI: [-0.19, -0.03]) were protective against psychological distress. Psychological distress was associated with male respondents (AMECoef 0.07, 95% CI: [0.02, 0.11]), low or medium resilient copers (AMECoef 0.89, 95% CI: [0.17, 1.61]), and perceiving a serious impact of social distancing measures (AMECoef 0.17, 95% CI: [0.09, 0.26]).

Conclusions
Psychological distress among Indian population during lockdown was prevalent. Poor coping ability and perceiving social distancing to have a serious impact was found to be significantly contributing to psychological distress. Appropriate measures to address these issues would be beneficial for the community mental health.
Hand(y) hygiene insights: Applying three theoretical models to investigate hospital patients’ and visitors’ hand hygiene behavior
Authors: Gaube Susanne , Fischer Peter , Lermer Eva 
Published: January 2021

Background
Improving hand hygiene in hospitals is the most efficient method to prevent healthcare-associated infections. The hand hygiene behavior of hospital patients and visitors is not well-researched, although they pose a risk for the transmission of pathogens. Therefore, the present study had three aims: (1) Finding a suitable theoretical model to explain patients’ and visitors’ hand hygiene practice; (2) Identifying important predictors for their hand hygiene behavior; and (3) Comparing the essential determinants of hand hygiene behavior between healthcare professionals from the literature to our non-professional sample.

Methods
In total N = 1,605 patients and visitors were surveyed on their hand hygiene practice in hospitals. The employed questionnaires were based on three theoretical models: a) the Theory of Planned Behavior (TPB); b) the Health Action Process Approach (HAPA); and c) the Theoretical Domains Framework (TDF). Structural equation modeling was used to analyze the data. To compare our results to the determinants of healthcare workers’ hand hygiene behavior, we searched for studies that used one of the three theoretical models.

Results
Among patients, 52% of the variance in the hand hygiene behavior was accounted for by the TDF domains, 44% by a modified HAPA model, and 40% by the TPB factors. Among visitors, these figures were 59%, 37%, and 55%, respectively. Two clusters of variables surfaced as being essential determinants of behavior: self-regulatory processes and social influence processes. The critical determinants for healthcare professionals’ hand hygiene reported in the literature were similar to the findings from our non-professional sample.

Conclusions
The TDF was identified as the most suitable model to explain patients’ and visitors’ hand hygiene practices. Patients and visitors should be included in existing behavior change intervention strategies. Newly planned interventions should focus on targeting self-regulatory and social influence processes to improve effectiveness.
Usefulness of Sepsis-3 in diagnosing and predicting mortality of ventilator-associated lower respiratory tract infections
Authors: Gaudet Alexandre , Devos Matthieu , Keignart Sylvain , Pouly Olivier , Lecailtel Sylvain , Wallet Frédéric , Nseir Saad 
Published: January 2021

BackgroundEarly distinguishing ventilator-associated tracheobronchitis (VAT) and ventilator-associated pneumonia (VAP) remains difficult in the daily practice. However, this question appears clinically relevant, as treatments of VAT and VAP currently differ. In this study, we assessed the accuracy of sepsis criteria according to the Sepsis-3 definition in the early distinction between VAT and VAP.MethodsRetrospective single-center cohort, including all consecutive patients with a diagnosis of VAT (n = 70) or VAP (n = 136), during a 2-year period. Accuracy of sepsis criteria according to Sepsis-3, total SOFA and respiratory SOFA, calculated at time of microbiological sampling were assessed in differentiating VAT from VAP, and in predicting mortality on ICU discharge.ResultsSensitivity and specificity of sepsis criteria were found respectively at 0.4 and 0.91 to distinguish VAT from VAP, and at 0.38 and 0.75 for the prediction of mortality in VA-LRTI. A total SOFA ≥ 6 and a respiratory SOFA ≥ 3 were identified as the best cut-offs for these criteria in differentiating VAT from VAP, with sensitivity and specificity respectively found at 0.63 and 0.69 for total SOFA, and at 0.49 and 0.7 for respiratory SOFA. Additionally, for prediction of mortality, a total SOFA ≥ 7 and a respiratory SOFA = 4 were identified as the best-cut-offs, respectively yielding sensitivity and specificity at 0.56 and 0.61 for total SOFA, and at 0.22 and 0.95 for respiratory SOFA.ConclusionsSepsis criteria according to the Sepsis-3 definition show a high specificity but a low sensitivity for the diagnosis of VAP. Our results do not support the use of these criteria for the early diagnosis of VAP in patients with VA-LRTI.
Strong Reduction of Colorectal Cancer Incidence and Mortality After Screening Colonoscopy: Prospective Cohort Study From Germany
Authors: Guo Feng , Chen Chen , Holleczek Bernd , Schöttker Ben , Hoffmeister Michael , Brenner Hermann 
Published: January 2021

INTRODUCTION:
A claimed advantage of colonoscopy over sigmoidoscopy in colorectal cancer (CRC) screening is prevention of CRC not only in the distal colon and rectum but also in the proximal colon. We aimed to assess the association of screening colonoscopy use with overall and site-specific CRC incidence and associated mortality.

METHODS:
Information on use of screening colonoscopy as well as potential confounding factors was obtained at baseline in 2000–2002, updated at 2-, 5-, 8-, and 17-year follow-up from 9,207 participants aged 50–75 years without history of CRC in a statewide cohort study in Saarland, Germany. Covariate-adjusted associations of screening colonoscopy with CRC incidence and mortality, which were obtained through record linkage with the Saarland Cancer Registry and mortality statistics up to 2018, were assessed by Cox proportional hazards models with time-varying exposure information.

RESULTS:
During a median follow-up of 17.2 years, 268 participants were diagnosed with CRC and 98 died from CRC. Screening colonoscopy was associated with strongly reduced CRC incidence (adjusted hazard ratio [aHR] 0.44, 95% confidence interval [CI] 0.33–0.57) and mortality (aHR 0.34, 95% CI 0.21–0.53), with stronger reduction for distal (aHRs 0.36, 95% CI 0.25–0.51, and 0.33, 95% CI 0.19–0.59, respectively) than for proximal cancer (aHRs 0.69, 95% CI 0.42–1.13, and 0.62, 95% CI 0.26–1.45, respectively). Nevertheless, strong reduction of mortality from proximal cancer was also observed within 10 years after screening colonoscopy (aHR 0.31, 95% CI 0.10–0.96).

DISCUSSION:
In this large prospective cohort study from Germany, screening colonoscopy was associated with strong reduction in CRC incidence and mortality.
Colonic Intussusception Secondary to Hereditary Angioedema
Authors: Roy Justin , Vunnam Rama , Gorrepati Venkata Subhash , Bethards Deborah , McGarrity Thomas 
Published: January 2021

ABSTRACT
Hereditary angioedema (HAE) is a rare genetic disease with numerous gastrointestinal manifestations. Intussusception, although rare, has been a reported complication with documentation of bowel wall edema on endoscopy during an acute flare. With the advent of synthetic C1 esterase inhibitors, this disease has become more effectively treatable. This case report shows a HAE flare complicated by colonic intussusception, treated with C1 esterase inhibitor, with complete endoscopic resolution seen on hospital day 5. This case provides evidence that with proper medical treatment, an HAE flare with intussusception has the potential to resolve without any further need for surgical or endoscopic intervention.
The Emerging Battle: Lysosomal Acid Lipase Deficiency vs Familial Hypercholesterolemia in Children
Authors: Saad Michelle , Syed Sabeen 
Published: January 2021

ABSTRACT
Lysosomal acid lipase is an under-recognized enzyme involved in the modulation and expression of genes that part-take in the synthesis and uptake of cholesterol. We describe the unusual course of a 2-year-old patient who presented with hypercholesterolemia and elevated liver enzymes, initially misdiagnosed with familial hypercholesterolemia. The absence of a suggestive family history triggered further testing that revealed complete lysosomal acid lipase deficiency that typically presents in infancy as Wolman disease with failure to thrive, malabsorption, and liver failure. Interestingly, the patient's clinical picture suggested cholesteryl ester storage disease instead, a milder phenotype in older patients.
Viscosity prediction of hydrocarbon binary mixture using an artificial neural network-group contribution method
Authors: Nanvakenari Sara , Ghasemi Mitra , Movagharnejad Kamyar 
Published: January 2021

Abstract
In this study, the viscosity of hydrocarbon binary mixtures has been predicted with an artificial neural network and a group contribution method (ANN-GCM) by utilizing various training algorithm including Scaled Conjugate Gradient (SCG), Levenberg-Marquardt (LM), Resilient back Propagation (RP), and Gradient Descent with variable learning rate back propagation (GDX). Moreover, different transfer functions such as Tan-sigmoid (tansig), Log-sigmoid (logsig), and purelin were investigated in hidden and output layer and their effects on network precision were estimated. Accordingly, 796 experimental data points of viscosity of hydrocarbon binary mixture were collected from the literature for a wide range of operating parameters. The temperature, pressure, mole fraction, molecular weight, and structural group of the system were selected as the independent input parameters. The statistical analysis results with R
2 = 0.99 revealed a small value for Average absolute relative deviation (AARD) of 1.288 and Mean square error (MSE) of 0.001018 by comparing the ANN predicted data with experimental data. Neural network configuration was also optimized. Based on the results, the network with one hidden layer and 27 neurons with the Levenberg-Marquardt training algorithm and tansig transfer function for hidden layer along with purelin transfer function for output layer constituted the best network structure. Further, the weights and bias were optimized to minimize the error. Then, the obtained results of the present study were compared with the data from some previous methods. The results suggested that this work can predict the viscosity of hydrocarbon binary mixture with better AARD. In general, the results indicated that combining ANN and GCM model is capable to predict the viscosity of hydrocarbon binary mixtures with a good accuracy.