bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluasi Desain Bangunan Berdasarkan Sistem Sertifikasi DGNB (Studi Kasus : The Khabele School, Austin)
Authors: Wicaksono Dady , Sugini Sugini 
Published: October 2021

<p class="Abstract"><em><span lang="EN-GB">The air pollution problem had become a big problem for many cities in the world. In line with the rapid development of these cities, the concept of sustainability also continues to develop with various solutions to overcome existing problems. To solve the air pollution problem, the authors evaluated the selected building object, The Khabele School, to see the extent of the building's contribution to overcoming the air pollution problem. The evaluation was carried out based on the DGNB (German Sustainable Building Council) certification system, the variables measured were biotope area factor (BAF), indoor air quality, daylight factor, and zero-carbon mobility. The results reveal that indoor air quality and daylight factors could meet the desired standards, while BAF and zero-carbon mobility had not met the standard. Based on theoretical and empirical studies, this paper discussed alternative design strategies, to improve the quality of the building, so that they can contribute more to overcoming air pollution problem.</span></em></p>
Preferensi Kenyamanan Pengunjung di Kebun Raya Bogor selama Adaptasi Kebiasaan Baru Berbasis Big Data
Authors: Paramitadevi Yudith Vega , Jannah Nurul , Mindara Gema Parasti 
Published: October 2021

<p><em>Urban communities need urban forests </em><em>in improving</em><em> the quality of </em><em>mental </em><em> and physical health during the New Normal. If </em><em>eco</em><em>tourism or urban forest is a top priority in implementing the New Normal, managers </em><em>must </em><em>determine designs, </em><em>and make </em><em>procedures related to the applicable COVID-19 protocol. The research objective was to measure the comfort level of visitors before and during the pandemic using big data, then compile comfort design recommendations according to visitor preferences during the pandemic based on survey methods. </em><em>Social media Twitter and Google Map Review mentioning the Bogor Botanical Garden were collected a year before and six months during the pandemic. Analysis of text mining is carried out in order to obtain sentiment and initial perceptions about the Bogor Botanical Garden. Initial perceptions of visitors were used to construct the survey questionnaire. Furthermore, quantitative survey methods were used to analyze visitor activity and comfort. </em><em>Visitor comfort is limited to abiotic factors, namely accessibility, and facilities. Sentiment analysis shows pre-pandemic conditions had 48.26% more positive word frequency than during the pandemic for Twitter, but 23.29% less than during the pandemic for Google Map Review. Twitter are more sensitive to the current situation than Google Map Review. Positive perceptions of comfort include compliance management of KRB under the COVID-19 protocol (11.7%), better management (10.8%), well-maintained facilities and infrastructure (7.2%), and maintained hygiene (7.2%). Comfort design recommendations based on respondents' preferences for comfort (14.4%) include increasing the number of toilets, the number of rest areas, ramps for the elderly, areas and attractions to attract children, parks with new themes, and sustainability elements.</em></p>
Nilai Kearifan Rumah Hijau (Greenship Homes) Permukiman Pedesaan Lereng Gunung, kasus Desa Kledung, Temanggung
Authors: Rejeki V.G. Sri , Ndruru Romantio Veronika , Bella K. Gita Cynthia , Wafi Zia Amalia 
Published: October 2021

<p><em>The implementation of greenship homes rating tools on houses in residential areas has been carried out in recent times. On the other hand, in mountain settlements have the value of local wisdom considers the environment as the basis of settlement management. The purpose of this study found the value of green buildings mountain settlements, the case of Kledung Village, Wonosobo, using the analysis of greenship homes rating tools. Qualitative research is conducted by physical mapping methods and interviews to homeowner informants. The study used 12 purposive samples, which were defined based on four character locations. The results of the study, based on 4 character location of the case, greenship homes value is relatively similar / its same. There is no difference in value between one case than another, so that analysis is done at once. Overall, the results of the study explained that the greenship homes rating tool can be applied in kledung village. The result is 1) all buildings are larger than the ratio of greenship rating tools, 2) all houses have electricity meters and monitoring; 3) sorting of organic and inorganic waste; 4) pest management; 5) some houses use recicled, reuse, and local materials, 6) sunny utilization and solar entry into homes and cross-circulation wind management in houses. Uniquenesse's finding are 1) there is a minimum large tree in Kledung village, because the village has cold temperatures, high humidity and little daily sunlight time. In addition, the people in Kledung Village do not regulate clean water, because it is abundant in this village</em><em></em></p>
Tektonika Perpaduan Unsur Jawa Dengan Eropa Pada Pendopo Dalem Kabupaten Rembang
Authors: Afriyanto Deny Setya , Putri Pusparini Dharma , Pradipto Eugenius 
Published: October 2021

<p><em>Dalem Kabupaten Rembang (regent residence), including the Pendopo as part of the Dalem component, was built around 1750. This building has a traditional Javanese concept that combined colonial architectural elements. This study aims to see the philosophical aspects of the saka guru that may influence the tectonic fusion of Javanese and European elements. </em><em>In order to know the tectonic aspect of the Pendopo Dalem Kabupaten, this research using qualitative methods, while data collecting is conducted through literature study and observation. </em><em>The findings of this study can be seen from the philosophical aspect in the concept of the “papat kiblat lima pancer“, where is reflected in the main structure of the saka guru (wooden material). Where functions as the main structure of the pendopo. Wooden material have given the aspect of its function which resists lateral forces (wind) to the overall construction. Meanwhile, the cement brick material on saka rawa and saka emper continuing the roof load to its foundation, used as bearing wall system. </em></p>
THE EFFECT OF RECRUITMENT AND MOTIVATION TOWARD JOB PERFORMANCE OF MILITARY PERSONNEL SUBMARINE UNIT IN EASTERN FLEET COMMAND OF INDONESIAN NAVY
Authors: Kartiwa Iwa 
Published: October 2021

The objective of this research is to obtain information on the effect of recruitment and motivation toward job performance of Military Personnel Submarine Unit in Eastern Fleet Command of Indonesian Navy. This research using survey method with quantitative approach and path analysis technique. The population of research is 80 military personnel and sample involving 67 personnel as respondents were selected through simple random sampling. This research findings are (1) there is a positively direct effect recruitment on job performance. (2) there is a positively direct effect motivation on job performance (3) there is a positively direct effect recruitment on motivation. Therefore, the job performance of Submarine Unit military personnel can be improved through improvement of recruitment, and motivation.
PENGARUH KEPEMIMPINAN DAN IKLIM ORGANISASI TERHADAP REWARD DI SEKOLAH DASAR NEGERI KECAMATAN KEBON JERUK DAN CENGKARENG
Authors: Masnawati Neneng 
Published: October 2021

The purpose of this research is to determine the effect of leadership and organizational climate on reward school community elemtary school in village of kebon jeruk and cengkareng..The research methodology was survey which were selected by simple random sampling technique. Analysis and interpretation of the data indicate that (1) leadership has a positive direct effect in reward, (2) organizational climate has a positive direct effect in reward, (3) leadership has a positive direct effect in organizational climate.
Prehabilitative Resistance Exercise Reduces Neuroinflammation and Improves Mitochondrial Health in Aged Mice with Perioperative Neurocognitive Disorders
Authors: Liu Yan , Chu John Man Tak , Ran You , Zhang Yan , Chang Raymond Chuen Chung , Wong Gordon Tin Chun 
Published: November 2021

Abstract
Background

Perioperative neurocognitive dysfunction remains a significant problem in vulnerable groups such as the elderly. While experimental data regarding its possible pathogenic mechanisms accumulates, therapeutic options for this disorder are limited. In this study, we evaluated the neuroprotective effect of a period of preconditioning resistant training on aged mice following abdominal surgery. Further, we examined the underlying mechanism from the perspective of neuroinflammatory state and synaptic plasticity in the hippocampus.
Methods

18-month-old C57BL/6N mice were trained for 5 weeks using a ladder-climbing protocol with progressively increasing weight loading. Preoperative baseline body parameters, cognitive performance and neuroinflammatory states were assessed and compared between sedentary and trained groups of 9-month-old and 18-month-old mice. To access the neuroprotective effect of resistance training on postoperative aged mice, both sedentary and trained mice were subjected to a laparotomy under 3% sevoflurane anesthesia. Cognitive performance on postoperative day 14, hippocampal neuroinflammation, mitochondrial dysfunction and synaptic plasticity were examined and compared during groups.
Results

18-month-old mice demonstrated increased body weight, higher peripheral and central inflammatory status, reduction in muscle strength and cognitive performance compared with middle-aged 9-month-old mice, which were improved by resistance exercise. In the laparotomy group, prehabilitative resistant exercise improved cognitive performance and synaptic plasticity, reduced inflammatory factors and glial cells activation after surgery. Furthermore, resistance exercise activated hippocampal PGC-1α/BDNF/Akt/GSK-3β signaling and improved mitochondrial biogenesis, as well as ameliorated mitochondrial dynamics in postoperative aged mice.
Conclusions

Resistance exercise reduced risk factors for perioperative neurocognitive disorders such as increased body weight, elevated inflammatory markers, and pre-existing cognitive impairment. Accordantly, the preoperative resistance exercise was found to improve surgery-induced adverse effects including cognitive impairment, synaptic deficit and neuroinflammation, possibly by facilitate mitochondrial health through the PGC1-a/BDNF pathway.
NOL12 Acts as an Oncogenic Biomarker and Predicts the Efficacy of Immune Checkpoint Inhibitors in Hepatocellular Carcinoma
Authors: Huang Jianfeng , Kang Weibiao , Pan Shubo , Yu Changjun , Jie Zhigang , Chen Changyu 
Published: November 2021

Abstract
Background: Hepatocellular carcinoma (HCC) is a common malignancy with a poor prognosis worldwide. However, the pathogenesis of HCC remains poorly understood. Methods: Through data mining and analyses of The Cancer Genome Atlas (TCGA) datasets, the NOL12 expression in HCC was determined and the associations between its expression and patient survival and clinicopathological parameters were evaluated. The pro-tumorigenic roles of NOL12 on HCC in vitro were further verified by loss-of-function assay. The correlation between NOL12 expression and tumor-infiltrating immune cells (TICs) was analyzed by CIBERSORTx method. In addition, the risk signature based on 8 NOL12-related genes was established to accurately evaluate the prognosis of patients with HCC and to further predict the efficacy of immune checkpoint inhibitors (ICIs) in HCCResults: We found that NOL12 was significantly overexpressed in independent HCC datasets from TCGA database. High expression of NOL12 is associated with worse reduced overall survival (OS), high pathological grade, node metastasis and advanced clinical stage in patients with HCC. Moreover, NOL12 knockdown significantly inhibited cell proliferation, migration and invasion. CIBERSORTx analysis revealed that twelve types of TICs are correlated with NOL12 expression. The risk signature based on 8 NOL12-related genes is an independent prognostic factor for patients with HCC. The OS rate of patients in the low-risk score group was better than that in the high-risk score group. In addition, the total tumor mutation burden (TMB) in the high-risk score group increased significantly, and the risk scores could be used as an alternative indicator of ICI response. Conclusions: Our findings indicated that NOL12 might be involved in the progression of HCC and can be used as a potential therapeutic target. Moreover, the NOL12-related risk signature may have predictive relevance with regard to ICI therapy.
Extraction Optimization, Structural Characterization, and Anti-Hepatoma Activity of Polysaccharides from Scutellaria Barbata D. Don
Authors: Su Wenwen , Wu Leilei , Liang Qichao , Lin Xiaoyue , Xu Xiaoyi , Yu Shikai , Lin Yitong , Fu Yang , Zhou Jiadong , Zhang Bo , Li Li , Li Dan , Yin Yongkui , Song Gaochen 
Published: November 2021

Abstract
Background The above experimental results show that SBP-2A isolated and purified from Scutellaria barbata may be a candidate drug for further evaluation in cancer prevention, which provides a clue for further studies on the molecular mechanism of its anticancer activity against human liver cancer cells.Methods The crude polysaccharide of Scutellaria barbata (SBP) was extracted with water and precipitated with alcohol. Optimal extraction conditions were determined by response surface methodology: the solid-liquid ratio was 1:25, the extraction time was 2 h, and the extraction temperature was 90 °C. With these conditions, the average extraction efficiency was 3.85 ± 0.13%. SBP was purified with a DEAE-52 cellulose column and Sephadex G-100 dextran gel column to obtain SBP-1A and SBP-2A fractions. The polysaccharide content, molecular weight, monosaccharide composition and basic structure were preliminarily identified. Then, a MTT assay was used to identify the polysaccharide components with anti-hepatoma effects. The antitumor activity of SBP-2A was evaluated by colony formation tests, morphological observations, apoptosis and cell cycle analyses.Results Structural analysis showed that SBP-1A and SBP-2A were mainly composed of arabinose and galactose, but the molar ratios were different; these were homogeneous acidic polysaccharide components with high purity, and the average molecular weights were 1.15 × 105 Da and 1.4 × 105 Da, respectively. FT-IR spectra showed that SBP-1A and SBP-2A contained uronic acid β-glucan, and the sugar residue of the polysaccharide was mainly pyranose. MTT and colony formation assays showed that SBP-2A significantly inhibited the proliferation of HepG2 cells. The cell distribution at different apoptotic stages was determined by the Hoechst 33258 test and Annexin V-FITC/PI staining. Flow cytometric analysis showed that SBP-2A induced HepG2 cell apoptosis by blocking the G1 phase.Conclusions Two polysaccharides (SBP-1A and SBP-2A) had been isolated from Scutellaria barbata. Preliminary characterization of the SBP-1A and SBP-2A was investigated. The anticancer activities were studied in vitro. SBP-2A significantly inhibited the proliferation of HepG2 cells and induced cells apoptosis by blocking the G1 phase.
LncRNA PAXIP1-AS1 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Ovarian Cancer
Authors: Chen Buze , Lu Xiaoyuan , Zhou Qingmei , Chen Qing , Zhu Siyan , Liu Hui , Li Guilin 
Published: November 2021

Abstract
Background: The long non-coding RNA (LncRNA) PAXIP1 antisense RNA 1 (PAXIP1-AS1) was found to promote proliferation, migration, EMT, and apoptosis of ovarian cancer (OC) cells in OC cell lines, but the relationship between PAXIP1-AS1 expression and clinical characteristics, prognosis, and immune infiltration of OC patients and its regulatory network are unclear. Methods: QRT-PCR, Kruskal-Wallis test, Wilcoxon sign-rank test, logistic regression, Kaplan-Meier method, Cox regression analysis, Gene set enrichment analysis (GSEA), and immuno-infiltration analysis were used to evaluate the relationship between clinical characteristics and PAXIP1-AS1 expression, prognostic factors, and determine the significant involvement of PAXIP1-AS1 in function. Results: Low PAXIP1-AS1 expression in OC was associated with age (P=0.045), histological grade (P=0.011), and lymphatic invasion (P=0.004). Low PAXIP1-AS1 expression predicted a poorer overall survival (OS) (HR: 0.71; 95% CI: 0.55–0.92; P=0.009), progression free interval (PFS) (HR: 1.776; 95% CI: 1.067–2.955; P=0.001) and disease specific survival (DSS) (HR: 0.67; 95% CI: 0.51–0.89; P=0.006). And PAXIP1-AS1 expression (HR: 0.711; 95% CI: 0.542-0.934; P=0.014) was independently correlated with PFS in OC patients. GSEA demonstrated that neutrophil degranulation, signaling by Interleukins, GPCR-ligand binding, G alpha I signaling events, VEGFAVEGFR-2 signaling pathway, naba secreted factors, Class A 1 Rhodopsin-Like Receptors, PI3K-Akt signaling pathway, and Focal Adhesion-PI3K-Akt-mTOR-signaling pathway were differentially enriched in PAXIP1-AS1 high expression phenotype. PAXIP1-AS1 may inhibit the function of aDC, B cells, CD8 T cells, Cytotoxic cells, DC, iDC, Macrophages, Mast cells, Neutrophils, NK CD56dim cells, T cells, TFH, Tgd, Th1 cells, Th2 cells and Treg. Conclusions: Low expression of PAXIP1-AS1 was significantly associated with poor survival and immune infiltration in OC. PAXIP1-AS1 could be a promising prognosis biomarker for OC.
Engaging Millennial Students through Flipped Classroom: Perspectives from Faculty, Undergraduate Medical and Nursing Students
Authors: Sultan Amber Shamim , Ali Rahila , Zahid Nida , Akbar Rozmeen , Ali Mehdia Nadeem Rajab , Fatima Sadia , Ghias Kulsoom , Martins Russell , Tariq Muhammad , Ajani Khairulnissa 
Published: November 2021

Abstract
Background: The ‘flipped classroom’ is a teaching pedagogy where students are actively involved in the learning process. It reduces passivity, enables students to become active learners through reasoning and concept application, and facilitates student interaction with their peers and instructors. This instructional approach enhances retention and decreases distraction by engaging students.The purpose of this study was to train the faculty of the medical college and school of nursing in adapting flipped classrooms (FCR) as a strategy and to facilitate them in conducting sessions for their learners. Methods: This study was conducted from July 2019 to September 2020. Three training workshops were conducted for faculty participants. The workshop was designed in a flipped style format in which pre-reading material was shared in advance with the workshop participants. A discussion board was created on Pad-let to engage workshop participants prior to the face-to-face (F2F) session. Kahoot was used to assess prior knowledge at the beginning of the F2F session. A video on flipped classroom was uploaded along with a few questions in between to check their basic understanding of the topic. Workshops’ participants conducted sessions for medical and nursing students and participated in focus group discussions (FGD) to share their experiences. Students’ perspectives were also obtained after their FCR session through a structured questionnaire.Results: Both medical and nursing students found FCR format stimulating. A significantly higher proportion of medical students (73%) found the FCR more engaging and interesting than a traditional lecture as compared to nursing students (59%) (p= 0.009). Similarly, 73 % of medical students believed the learning objectives of both the non-face-to-face (NF2F) and face-to-face (F2F) sessions were shared with them as compared to the 62% of nursing students who believed the same (p=0.002). A significantly higher proportion of medical (76%) versus nursing (61%) students found the FCR format more useful for application of their theoretical knowledge into clinical practice (p=0.030).Conclusion: Students found the flipped classroom (FCR) more engaging and interesting in terms of applying theoretical knowledge into practice. It is recommended to conduct more FCR sessions for an interactive and student-centered learning experience.
Association between Serum Uric Acid to HDL-cholesterol Ratio and Nonalcoholic Fatty Liver Disease among Chinese Adults
Authors: Zhao Hui , Qiu Xia , Cui Jiajia , Sun Yongye 
Published: November 2021

Abstract
We conducted this case-control study to explore the association of serum uric acid (SUA) to HDL-cholesterol (HDL-C) ratio (UHR) with the risk of nonalcoholic fatty liver disease (NAFLD) in general Chinese adults. A total of 636 patients with NAFLD and 754 controls from affiliated hospital of Qingdao University in China between January to December 2016 were involved. NAFLD was diagnosed by ultrasonography after excluding other etiologies. The multivariable adjusted odds ratio and 95% confidence interval (CI) of NAFLD for the highest versus lowest quartile of UHR was 3.888 (2.324-6.504). In stratified analyses by sex and age, the positive associations between UHR and the risk of NAFLD were statistically significant in each subgroup. In stratified by BMI, the significant positive association was only found in the individuals with BMI≥23.9 kg/m2. Dose-response analysis indicated a linear positive correlation between UHR and NAFLD risk.
Oblique Lateral Interbody Fusion Combined with Lateral Plate VS. Combined with Posterior Pedicle Screw Fixation in Lumbar Degenerative Diseases
Authors: Li Hai-dong , Zhong Li , Fang Xiang-Qian , Jiang Lei-Sheng 
Published: November 2021

Abstract
Background The oblique lateral interbody fusion (OLIF) is a minimally invasive indirect decompression technique for the treatment of degenerative spinal disease. OLIF with posterior pedicle screws fixation frequently is performed, whereas it requires much more surgery time and blood loss. The purpose of this study was to compare the oblique lateral interbody fusion (OLIF) combined with lateral plate (LP) vs. OLIF combined with posterior pedicle screw (PS) fixation for the treatment of lumbar degenerative diseases.Methods The clinical data of 53 patients with lumbar degenerative diseases who underwent OLIF from January 2020 to September 2020 were retrospectively analyzed，24 in OLIF combined with lateral plate (OLIF+LP) group and 29 in OLIF combined with pedicle screw (OLIF+PS) group. All patients completed a minimum 1-year follow-up. The duration of operation, blood loss, fusion rate and complications were recorded. The visual analog scale (VAS) score, Oswestry Disability Index (ODI), disc height (DH), foraminal height (FH) and cross-sectional area (CSA) were also evaluated.Results The operation time was 75.41±11.53 min in the OLIF+LP group, which shorter than that in OLIF+PS group(127.05±5.62min, P<0.01). Also, the blood loss was significantly less in the OLIF+LP group (39.55±5.32 ml ) than in the OLIF+PS group (89.81±9.62, P<0.01). The VAS and ODI scores both significantly reduced after operation in OLIF+LP group. There was no difference either in VAS or ODI scores by 1 year after surgery between two groups (P>0.01). The DH, FH, and CSA parameters were all improved significantly after operation in both groups, however, there was no significant difference at the any follow-up point between the two groups. The total complication rate was 13.21% (7/53) in this study, and there was no siginificant difference between the two groups. The fusion rate was 91.67% in the OLIF+LP group and 93.10% in the OLIF+PS group (P =0.69).Conclusions OLIF+LP fixation seems to be a valuable surgical option for single-segmental lumbar degenerative disease, it can achieve much better clinical outcomes than OLIF+PS group.