bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efektivitas E-Modul Kimia Lingkungan Berbasis Etnosains Terintegrasi Stem Untuk Meningkatkan Keterampilan Berpikir Kritis Dan Literasi Lingkungan
Authors: Al Idrus Syarifah Wahidah , Rahmawati Rahmawati 
Published: December 2024

Penelitian ini bertujuan untuk melihat pengaruh penerapan e-modul Kimia Lingkungan berbasis etnosains terintegrasi STEM. Sampel penelitian adalah mahasiswa UIN Mataram dengan jumlah 32. Metode yang digunakan dalam penelitian ini adalah pre- eksperimen dengan desain One Group Pretest-Postest Design. Kelompok sampel diberi pretest sebelum perlakuan menggunakan sumber belajar e-modul Kimia Lingkungan berbasis etnosains terintegrasi STEM. Setelah perlakuan, diberikan posttest pada mahasiswa dengan instrumen keterampilan berpikir kritis dan literasi lingkungan. Analisis yang digunakan dalam penelitian ini adalah n-gain. Hasil persentase n-gain keterampilan berpikir kritis adalah 60,01 dengan kriteria sedang dan hasil persentase n-gain literasi lingkungan adalah 71,54 dengan kriteria tinggi. Analisis n-gain untuk masing-masing indikator keterampilan berpikir kritis menunjukkan interpretasi memiliki hasil tertinggi dibandingkan indikator yang lain dengan persentase 70,03. Analisis n-gain untuk masing-masing indikator literasi lingkungan menunjukkanindikator pengetahuan memiliki hasil tertinggi dibandingkan indikator yang lain dengan persentase 73,08. Hasil-hasil analisis yang diperoleh menunjukkan telah terjadi peningkatan keterampilan berpikir kritis dan literasi lingkungan mahasiswa setelah dilakukan proses belajar menggunakan e-modul Kimia Lingkungan berbasis etnosains terintegrasi STEM.
TELAAH HADITS KEUTAMAAN DAN URGENSI MENUNTUT ILMU DI ERA DIGITAL: RELEVANSI DENGAN TANTANGAN PENDIDIKAN MODERN DAN KRITERIA PENDIDIK IDEAL
Authors: Agustina Tarik Atika , Kurjum Muhammad 
Published: December 2024

This study aims to determine how the existence of the study of hadith science on the virtues and urgency of seeking knowledge in the digital era can be used in the application of principles in modern education today. Knowledge is an obligation that will always be attached to a Muslim. Because it can be seen that seeking knowledge is part of worship. The research method used is library research with a historical approach and hadith science, including criticism of sanad and matan to analyze the validity of related hadiths. This study utilizes sources from Maktabah Syamilah and other literature such as books, journals, and articles. Through research with this method, it can be found that the hadith of the Prophet has emphasized the importance of seeking knowledge for every Muslim. However, in the current digital era, where information is easily accessible to anyone, it certainly becomes an awareness for ourselves to need a more critical approach in filtering and utilizing knowledge. In addition, this study discusses the ideal criteria for an educator in the digital era, which include the ability to use technology wisely, assess information critically, and guide students in dealing with social and technological changes. Another thing that is a point of discovery in this study is that the principles of the Hadith of the Prophet can provide solutions to the challenges of education in the modern era today.
Penelitian ini bertujuan untuk mengetahui bagaimana eksistensi kajian ilmu hadits tentang keutamaan dan urgensi menuntut ilmu di era digital dapat digunakan dalam penerapan prinsip – prinsip pada pendidikan modern saat ini. Ilmu merupakan suatu kewajiban yang hingga kapanpun melekat pada diri seorang Muslim. Karena dapat diketahui bahwa menuntut ilmu ialah bagian dari suatu ibadah. Metode penelitian yang digunakan adalah studi pustaka (library research) dengan pendekatan historis dan ilmu hadits , termasuk kritik sanad dan matan untuk menganalisis validitas hadits -hadits terkait. Studi ini memanfaatkan sumber-sumber dari Maktabah Syamilah serta literatur lain seperti buku, jurnal, dan artikel. Melalui penelitian dengan metode demikian dapat ditemukan bahwa hadits Rasulullah telah menekankan tentang pentingnya dalam menuntut ilmu bagi setiap Muslim. Namun di era digital saat ini, dimana informasi dengan mudah diakses oleh siapapun, tentu menjadi kesadaran bagi diri kita sendiri untuk lebih membutuhkan pendekatan kritis dalam menyaring dan memanfaatkan pengetahuan. Selain itu, penelitian ini membahas kriteria ideal bagi seorang pendidik di era digital, yang meliputi kemampuan untuk memanfaatkan teknologi secara bijaksana, menilai informasi dengan kritis, serta membimbing siswa dalam menghadapi perubahan sosial dan teknologi. Hal lain yang menjadi point penemuan pada penelitian ini yaitu prinsip – prinsip Hadits Rasulullah dapat memberikan solusi terhadap tantangan pendidikan di era modern saat ini.
Vedet ja vesistöt koulumatkamuistojen maisemassa
Authors: Granö Päivi 
Published: December 2024

Artikkelin aiheena ovat visuaaliset, ylisukupolviset, dialogissa tuotetut koulumatkakuvaukset. Kuvien ja niihin liittyvien tekstien pohjalta tarkastelen koulumatkamuistoja, joissa esiintyy vesielementti jossakin muodossaan. Keskeisiä näkökulmia ovat paikkaan sitoutuvat keholliset tunnemuistot ja niiden sanallinen ja visuaalinen kerronta. Aineiston tuottivat keväällä 2022 kahdeksan opettajaopiskelijaa opintotehtävänään yhdessä isovanhempansa tai vanhempansa kanssa dialogisena piirtämis- ja kerrontaprosessina. Metodi perustuu kulttuuriseen visuaaliseen analyysiin. Keskeisimmät muistutetut vesimaisemat olivat joet. Erityisesti sillat herättivät muistoja aistikokemuksista ja sosiaalisista suhteista. Nuoremmalle sukupolvelle muistelujen kuuleminen ja kuvien työstäminen oli tärkeä kokemus.
Muistaa-verbi kerronnallisen asemoinnin välineenä kansanedustajien muistitietohaastatteluissa
Authors: Jolma Nanny Ira Marita , Teräs Kari 
Published: December 2024

Muistaa-verbi on muistitietohaastatteluissa toistuvasti esiintyvä kielen keino, jonka funktioiden ja merkitysten systemaattinen tarkastelu on jäänyt tutkimuksessa huomiotta. Tämä artikkeli tutkii muistaa-verbin käyttöä osana muistelevan kerronnan keinoja entisten kansanedustajien muistitietohaastatteluissa. Eduskunnan kirjaston keräämää haastatteluaineistoa lähestytään kertomuksentutkimuksen ja muistitietohistorian näkökulmista. Laajuutensa ja jatkuvuutensa vuoksi kansainvälisestikin ainutlaatuinen aineisto on jäsennetty tekstimuotoiseksi tietokannaksi, josta on digitaalisin menetelmin poimittu kokoelma muistaa-verbin esiintymiä kerronnallisissa yhteyksissä. Esimerkkikatkelmien laadullinen analyysi keskittyy erityisesti muistaa-verbin käyttöön kerronnallisen asemoinnin teoriaa soveltaen. Haastatteluissa rakentuvia kertomuksia tarkastellaan sekä sosiaalisena toimintana ja vuorovaikutuksena että identiteetin muodostamisen välineenä.
Artikkelissa tarkastellaan, miten muistamisen tai muistamattomuuden sanallistaminen toimii kerronnallisena välineenä kansanedustajien muistitietohaastatteluissa sekä miten haastateltavat asemoivat itseään muistaa-verbin avulla myös suhteessa muistitietoa ja poliittista uraa koskeviin odotuksiin. Analyysin olennaisena lähtökohtana on kerronnan ja tarinan tasojen erottaminen. Kerronnallisen asemoinnin teorian mukaisesti huomio kiinnittyy myös näiden tasojen väliseen liikkeeseen ja sitä kautta syntyviin laajempiin identiteettiin ja normeihin liittyviin asemointeihin.
Analyysi havainnollistaa, että muistitietohaastatteluissa toistuvuudessaan arkiselta vaikuttavan muistaa-verbin funktiot eivät rajoitu menneisyyden uudelleen tulkinnan ja osallisuuden ilmaisemiseen. Sen sijaan muistaa-verbin avulla kerronnalliseen vuorovaikutukseen tuotetaan runsaasti erilaisia, toistensa kanssa limittäisiä ja ristiriitaisiakin merkityksiä.
Vesi vanhin voitehista
Authors: Kallio Kati 
Published: December 2024

Tulkintoja historiallisesta kansanperinteestä käytetään yhteiskunnassa laajasti. Laajoja kansanperinneaineistoja kattavat tutkimukset on kuitenkin tehty pääosin jo 1900-luvun alkupuolella oman aikansa tulkintakehysten puitteissa. Tämän tutkimuksen kriittiselle arvioinnille, lähteiden uudelleenluennoille ja tutkimustiedon popularisoinnille on suuri tarve. Tallentunut historiallisen kansanperinteen aineisto on kuitenkin valtava ja vaikeasti tulkittava. Digitaaliset menetelmät luovat mahdollisuuksia laajojen sähköisessä muodossa olevien aineistojen nopeampaan ja laajempaan tarkasteluun, mutta niihin sisältyy myös monenlaisia rajoitteita.
Tässä artikkelissa annan esimerkin siitä, miten moninainen ja monitulkintainen voi olla yhdenkin lyhyen, nykykulttuurissa käytetyn sananlaskun historiallinen käyttö- ja merkitystausta. Samalla käsittelen digitoidun karjalais-inkeriläis-suomalaisen kansanrunousaineiston laskennallisesti avustetun luennan menetelmällisiä mahdollisuuksia ja ongelmakohtia.
Kansanrunoudessa ajatus veden vanhuudesta kiteytyy vaihtelevien rinnakkais- eli paralleelisäkeiden ryppäiksi. Yleisin keskeissäkeen muoto on ”Vesi vanhin veljeksistä”. Aihelmien yleisin, joskaan ei ainoa käyttöyhteys on rautaan, tuleen, puuhun tai käärmeeseen liittyvä parannusloitsu. Vesi vanhin voitehista -muoto esiintyy erityisesti saunassa löylyn ja kylvettämisen avulla parantamisen, voiteen valmistamisen sekä Tulen sanojen yhteydessä. Aineistosta aukeaa laaja mielikuvien ja motiivien verkosto, jossa vesi asettuu vanhimmaksi ja linkittyy paikoin Väinämöiseen. Itämerensuomalaisen suullisen runouden maailmassa vanhuus tarkoittaa tietoa ja tieto puolestaan väkevyyttä, kykyä vaikuttaa asioihin ja hallita niitä.
Vesi vanhin voitehista -säkeen nykyinen sananlaskunomainen käyttö asettuu jatkumoon edeltävien suullisten käyttöjen kanssa, mutta linkittyy ennemminkin nykykulttuurin proosamuotoisten ilmaisujen kuin historiallisen runokulttuurin kanssa. Paljon aiempia merkityksiä tai merkitystasoja – kuten ajatus vanhuuden voimasta tai loitsuilla, löylyllä ja kylvettämisellä parantamisesta – on jäänyt taa, mutta etenkin kytkös saunaan puhdistumisen paikkana pysyy.
Current Mesalazine Products: Differences in Enteric-Coated Dosage Forms and Pharmaceutical Risks of Clinical Efficacy Reduction (Review)
Authors: Serebrova S. Yu. , Evteev V. V. , Demchenkova E. Yu. , Zhuravleva M. V. , Prokofiev A. B. 
Published: December 2024

INTRODUCTION. Oral mesalazine (5-aminosalicylic acid) products are commonly used to treat inflammatory bowel disease, in particular, ulcerative colitis. The clinical efficacy of these medicinal products depends directly on the composition and properties of the polymers used to deliver mesalazine to the affected areas of the colon. However, the information that has been accumulated to date suggests that the release of mesalazine from enteric-coated dosage forms in gastrointestinal tract simulations differs from that in the actual human gastrointestinal tract, which necessitates further research.AIM. This study aimed to systematise information on the polymers used in the enteric coating of mesalazine products and to assess the pharmaceutical risks associated with the potential reduction in the efficacy of ulcerative colitis therapy.DISCUSSION. The absorption and metabolism of mesalazine dictate the need for enteric-coated dosage forms to deliver the active substance directly to the affected areas of the colon. The most common polymer used in the manufacturing of oral mesalazine products is a methacrylic acid–methyl methacrylate copolymer with a monomer ratio of 1:1, which releases the active substance at pH 7.0. Some manufacturers use a methacrylic acid–ethyl acrylate copolymer with a monomer ratio of 1:1, which dissolves at pH 5.5. The gastrointestinal pH in patients with inflammatory bowel disease may vary in wide and often overlapping ranges depending on the organ (1.0–7.0 in the stomach, 5.0–6.2 in the duodenum, 6.1–7.1 in the jejunum, 7.4–7.5 in the ileum, and 5.7–7.5 in the colon with a possibility of acidification in ulcerative colitis patients). The rate of gastrointestinal transit varies widely as well. These factors may cause premature release of mesalazine in the stomach or the small intestine before the dosage form reaches the colon, which poses the risks of reduced clinical efficacy and systemic adverse effects.CONCLUSIONS. In the vast majority of ulcerative colitis patients, the methacrylic acid–methyl methacrylate copolymer provides targeted delivery of 5-aminosalicylic acid from tablets and granules, facilitating its local action in the colon. However, developers and manufacturers selecting the polymer for enteric coating of oral mesalazine dosage forms should consider the pharmaceutical risks associated with reduced clinical efficacy.
Adverse Reactions to Intravenous Immunoglobulin Therapy: An Analysis of the Russian National Pharmacovigilance Database
Authors: Nechaev A. V. , Leshina S. A. , Klepikova A. G. , Gaiderova L. A. , Velts N. Yu. , Gorelov K. V. , Polivanov V. A. 
Published: December 2024

INTRODUCTION. Human immunoglobulins have been successfully used in clinical practice to treat multiple autoimmune and inflammatory conditions, and most of the current immunoglobulins are well tolerated by patients. However, patients may develop complications associated with proteins and other components of human plasma present in immunoglobulin products. The improvement of measures to ensure the quality, efficacy, and safety of immunobiologicals, including intravenous immunoglobulins (IVIGs), requires regular monitoring of data on individual and class-related adverse drug reactions (ADRs) associated with these medicinal products.AIM. This study aimed to conduct a systematic and comprehensive assessment of information on the potential ADRs to the IVIGs of Russian marketing authorisation holders from summaries of medicinal product characteristics (SmPCs) and the Russian national pharmacovigilance database.MATERIALS AND METHODS. The study analysed the SmPCs of all the IVIGs authorised for use in Russia and the spontaneous reports of ADRs to the IVIGs of Russian marketing authorisation holders. The study was limited to the spontaneous reports submitted to the database PHARMACOVIGILANCE/MONITORING OF CLINICAL TRIALS OF MEDICINES in the Automated Information System of the Federal Service for Surveillance in Healthcare from 1 January 2020 to 30 August 2024.RESULTS. At the time of the study, there were 20 normal human IVIGs authorised in Russia, and Russian companies held marketing authorisations for 9 of these IVIGs. During the study period, there were 133 cases of ADRs associated with the IVIGs of Russian marketing authorisation holders. The most common ADRs included 41 (16.5%) cases of hyperthermia, 14 (5.6%) cases of headache, 14 (5.6%) cases of urticaria, and 14 (5.6%) cases of treatment ineffectiveness. The majority of these cases (70%) occurred when IVIGs were used for approved indications.CONCLUSIONS. All the ADRs identified in the analysis of the Russian national pharmacovigilance database were expected and consistent with the ADRs labelled in the SmPCs of the reported IVIGs. To reduce the risk of ADRs and improve the safety of IVIG therapy, it is required to develop a comprehensive approach to human IVIGs with quality assurance measures and standard use guidelines.
WoE Analysis and Key Risk Factors in Preclinical Development of Medicinal Products: A Review
Authors: Engalycheva G. N. , Syubaev R. D. 
Published: December 2024

INTRODUCTION. In recent years, the Russian Federation and the Eurasian Economic Union have included the concept of ‘weight of evidence’ (WoE) in regulatory documents. International regulators place great emphasis on data transparency in documenting and assessing the WoE, and their position is reflected in the relevant regulatory documents. However, the Russian Federation has faced the absence of consistent Russian-language terminology in this area, the lack of a clear vision of WoE assessment principles, and the need for a sound understanding of applied WoE methods for pharmaceutical development and regulatory review of preclinical study results. These gaps require collated information on WoE assessment and practical guidance for its use.AIM. This study aimed to analyse regulatory documents as well as scientific and methodological publications on the WoE concept and assessment methods in order to investigate the opportunities and practical applications of WoE analysis in the development of medicines and the regulatory review of study results.DISCUSSION. This article covers documents by the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH), the Organisation for Economic Co-operation and Development (OECD), the European Chemicals Agency (ECHA), and other organisations. Using these documents and taking into account Russian terminology, the authors clarify the WoE as a concept and explain its assessment. Furthermore, the article classifies the key risk factors that must be considered in WoE analysis, with examples drawn from immunotoxicity, reproductive toxicity, and carcinogenicity studies. Analysing such data is critical to the design of preclinical studies, interpretation of their results, and safety evaluation of medicines. This article provides examples of WoE assessments conducted to consider the need for additional preclinical studies in juvenile animals in the development of small molecules and monoclonal antibodies for paediatric use.CONCLUSION. The WoE assessment algorithms and criteria described in this article may be implemented by preclinical study initiators, their research teams, and regulatory experts evaluating medicines.
Strategi Peningkatan Penjualan dan Pemasaran Melalui E-Commerce Produk UMKM Keripik ‘OdjoLali’ Way Jepara
Authors: Jatiningrum Citrawati , Abadi Satria , Siregar Syahrizal , Febriansyah Febriansyah , Angelia Febby 
Published: December 2024

UMKM di Indonesia menghadapi berbagai permasalahan operasional dan strategis dalam pengembangan bisnisnya. Masih banyaknya UMKM yang memiliki pemahaman yang kurang dan belum memanfaatkan teknologi digital dalam pemasaran produknya. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan strategi dalam upaya peningkatan penjualan bagi UMKM Keripik Ojo Lali Way Jepara kabupaten Lampung Timur melalui pemasaran E-Commerce. Peningkatan jangkauan pasar dan penguatan daya beli produk UMKM melalui penerapan e-commerce atau toko online bagi mitra dapat meningkatkan kemandirian ekonomi. Selain itu kegiatan ini meningkatkan penggunaan teknologi informasi dan internet dalam kegiatan pemasaran produk. Metode yang dilakukan dilakukan dalam beberapa tahapan, yaitu dilakukan dimulai dari observasi awal, persiapan, pelaksanaan, pelatihan pendampingan hingga evaluasi kegiatan. Hasil kegiatan pengabdian ini yaitu kegiatan pelatihan dan pendampingan penerapan E-Commerce bagi UMKM produk keripik Ojo Lali memberikan manfaat yang signifikan bagi peningkatan penjualan dan pemasaran produk bagi masyarakat lokal maupun antar kota. Kegiatan ini juga memberikan keterampilan bagi mitra untuk dapat melakukan pemasaran digital sebagai upaya meningkatkan daya saing produk dan keberlangsungan usaha di masa yang akan datang.
An overview of The Influence of Natural Disasters on Writings of Mohammed Khaïr-Eddine (1967), Ito Sei (2008) and Makenzy Orcel (2020) (Earthquakes as a Case Study)
Authors: Abouabdelmajid Mariyem , Khadija Anasse  
Published: December 2024

This article analyzes the link between the stream of consciousness techniques and the different earthquakes that rocked the globe from 1923 to 2010. The paper focuses on the Great Kanto earthquake of 1923 in Japan followed by the famous natural disaster which is the Moroccan earthquake of Agadir in 1960. This work also deals with a more recent disaster which is the Haiti earthquake of 2010. Actually, these natural disasters have in common the stream of consciousness techniques used by the three writers. Indeed, whether it be Japanese writer Ito Sei (2008), Moroccan author Mohammed Khaïr-Eddine (1967) or Haitian author Makenzy Orcel (2020), they are all making use of the river-like methods known as the stream of consciousness techniques in their writings. The style employed in their works is referred to as “seismic writing” since it mimics the quake-caused fissured lands and turn them into literature. This paper relies on a qualitative methodology. Indeed, this approach is the most suitable one as it compares the main works of three major writers who use new literary devices as a response to the natural catastrophes of the time. The value added of this paper consists of providing a comparative study of the works of three writers from different countries while considering the ways in which they use “seismic writing” to confront the earthquakes. The study proves that each writer has his unique characteristics while sharing commonalities and differences with the others. All of the writers use a fragmented narration and also a polyphonic dimension to offer a voice to the victims. While some may employ various genres, others limit themselves to prose. This study brings about the shared aspects used while highlighting the singularities of each author.
Synthesis and Characterization of 5-Fluoroacil Loaded Calcium Carbonate Nanoparticles for Targeted Cancer Therapy
Authors: Salem Kshidan Marim Abdullah , Ibrahim Mohamed Ahmed , Chan Kim Wei , Abu Bakar Md Zuki , Alitheen Noorjahan Banu , Alsubbi Mohammed , Abdull Razis Ahmad Faizal , Ismail Norsharina 
Published: December 2024

<img src=” https://s3.amazonaws.com/production.scholastica/article/127799/large/prnano_1622024ga.jpg?1736142025”> Chemotherapy is often limited by its systemic toxicity and lack of specificity, necessitating the development of targeted drug delivery systems that can enhance therapeutic efficacy while minimizing adverse effects. Addressing this, our study aimed to synthesize and characterize 5-Fluorouracil loaded calcium carbonate nanoparticles derived from cockle shells. The research aimed at increasing site-specific drug release and reducing cytotoxicity. The nanoparticles were prepared using a simple co-precipitation method, ensuring eco-friendliness and cost-effectiveness. The encapsulation of 5-FU was confirmed by transmission electron microscopy (TEM), which revealed an increase in nanoparticle size from 19.2 ± 2.284 nm for the unloaded ones to 34.8 ± 4.066 nm for the 5-FU-loaded CaCO3 NPs. In vitro release studies demonstrated a pH-sensitive release profile, with more rapid drug release at pH 4.8 compared to pH 7.3. Bio-compatibility assays on the HS-27 human skin fibroblast cell line indicated high cell viability, with over 90% maintained even at high nanoparticle concentrations (1000 µg/mL). In addition, cytotoxicity assays on the SW480 (primary colon cancer) and SW620 (metastatic colon cancer) cell lines showed a dose-dependent decrease in cell viability and demonstrated a more controlled and sustained release compared to free 5-FU, resulting in higher cell viability at all time points and concentra-tions. The 5-FU-loaded CaCO3 NPs significantly reduced the immediate cytotoxic effects observed with free 5-FU while effectively targeting cancer cells. These findings suggest that the 5-FU-CaCO3 NPs offer a promising alternative to conventional chemotherapy, providing targeted drug delivery with the potential for reduced systemic toxicity and enhanced therapeutic efficacy.