bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radial symmetry for a generalized nonlinear fractional p-Laplacian problem
Authors: Hou Wenwen , Zhang Lihong , Agarwal Ravi P. , Wang Guotao 
Published: March 2021

This paper first introduces a generalized fractional p-Laplacian operator (–Δ)sF;p. By using the direct method of moving planes, with the help of two lemmas, namely decay at infinity and narrow region principle involving the generalized fractional p-Laplacian, we study the monotonicity and radial symmetry of positive solutions of a generalized fractional p-Laplacian equation with negative power. In addition, a similar conclusion is also given for a generalized Hénon-type nonlinear fractional p-Laplacian equation.
High-risk Behavior Screening and Interventions in Hospitalized Adolescents
Authors: Pfaff Nora , Pantell Matthew S. , Kaiser Sunitha V. 
Published: March 2021

BACKGROUND AND OBJECTIVES:Risky behaviors are the main threats to adolescents’ health. Consequently, guidelines recommend adolescents be screened annually for high-risk behaviors. Our objectives were to (1) determine rates of physician-documented risk behavior screening of hospitalized adolescents, (2) determine rates of positive screening results, and (3) evaluate associations between risk behavior screening and provision of risk behavior–related health care interventions.METHODS:We conducted a cross-sectional study of patients aged 12 to 24 years admitted to the pediatric hospital medicine service at an urban tertiary children’s hospital from January to December 2018. Exclusion criteria were transfer to a different service, nonverbal status, or altered mental status. We reviewed 20 charts per month. Outcomes included (1) documentation of risk behavior screening (mood, sexual activity, substance use, abuse and/or violence, and suicidal ideation), and (2) risk behavior–related health care interventions (eg, testing for sexually transmitted infections). We determined associations between screening and risk behavior–related interventions using χ2 tests.RESULTS:We found that 38% (90 of 240) of adolescents had any documented risk behavior screening, 15% (37 of 240) had screening in 4 of 5 risk behavior domains, and 2% (5 of 240) had screening in all 5 domains. The majority of screened adolescents had a positive screening result (66%), and most with positive results received a risk behavior–related health care intervention (64%–100% across domains). Adolescents with documented screening were significantly more likely to receive a risk behavior–related health care intervention.CONCLUSIONS:We found low rates of risk behavior screening documentation among hospitalized adolescents. There was a high rate of positive screen results, and those who were documented as screened were more likely to receive risk behavior–related interventions.
Seismic analysis of bridges with non-linear soil-structure interaction
Authors: Boubel Hasnae , Elmrabet Oumnia , Echebba Elmehdi , Rougui Mohamed 
Published: March 2021

AbstractThis study is concerned to the investigation of the stability of bridges by taking into account the soil structure interaction and their impact on the dynamic behavior of the structures. The bridge studied is localized at PK 318 + 750 at the national level, between the city of Al Hoceima and Kasseta (Morocco). The analyses are carried out with the ANSYS code demonstrated that for conditions of support, the distribution of displacements and the fundamental frequency for each type of soil change according to its mechanical properties. This work also indicates that the proximity of the fundamental frequencies of the soil structure and strongly influences the soil-structure interaction.
Penerapan Model Supervisi SUKSES-ME untuk Membangun Penguatan Pendidikan Karakter di Sekolah
Authors: Saparudin Yudhi 
Published: March 2021

Hasil deskripsi pengembangan Penguatan Pendidikan Karakter (PPK) di sekolah binaan sebelum implementasi model Supervisi Klinis-Kolaborasi, Penilaian Sendiri-Sejawat, Monitoring, dan Evaluasi (SUKSES-ME) menunjukkan bahwa, pengembangan PPK berbasis kelas pada Silabus dan RPP, PPK berbasis budaya pada kegiatan non kurikuler; membersihkan lingkungan sekolah, upacara bendera, menyanyikan lagu nasional/daerah, membaca buku bersama baru, dan bakti sosial serta pengembangan PPK pada proses pembelajaran masih belum optimum. Penelitian ini bertujuan untuk menerapkan model supervisi kreatif yaitu model SUKSES-ME untuk meningkatkan PPK di Sekolah Menengah Atas (SMA). Metode penelitian yang digunakan adalah penelitian deskriptif menggunakan uji t, untuk melihat PPK sebelum dan sesudah implementasi model SUKSES-ME di SMAS Nugraha Bandung. Hasil penelitian menunjukkan bahwa penerapan model SUKSES-ME dapat meningkatkan PPK di SMAS Nugraha Bandung, baik pada struktur kurikulum (silabus dan RPP), pengembangan PPK berbasis budaya sekolah, dan pengembangan PPK pada proses pembelajaran. Peningkatan tersebut signifikan dengan nilai p &lt; 0.05. Kesimpulan dari penelitian, supaya penerapan model SUKSES-ME ini optimal, maka harus dilakukan secara berkelanjutan dan berkesinambungan mulai siswa masuk sampai lulus sekolah
Peningkatan Keterampilan Menulis Deskripsi Melalui Metode Problem Based Learning di Kelas IV SDN 3 Selajambe
Authors: Nugraha Junaedi , M.S Zulela , Fuad Nurhattati 
Published: March 2021

<span lang="IN">Penelitian ini bertujuan untuk meningkatkan keterampilan menulis deskripsi melalui metode <em>problem based learning</em> pada siswa kelas IV SDN 3 Selajambe Kabupaten Kuningan. Penelitian ini merupakan penelitian tindakan kelas dengan menggunakan model Kemmis dan Mc Taggart yang dilakukan dalam dua siklus. Setiap siklus terdiri dari empat tahapan yaitu: Perencanaan,</span><span lang="IN">Tindakan, Observasi</span><span lang="IN">dan Refleksi. Pengumpulan data dilakukankan menggunakan instrumen tes menulis deskripsi, lembar pemantau tindakan dan dokumentasi. Hasil penelitian menunjukan adanya peningkatan keterampilan menulis deskripsi pada siswa kelas IV SDN 3 Selajambe Kabupaten Kuningan melalui metode <em>problem based learning</em>. Peningkatan ini dilihat dari nilai rata-rata produk dan ketuntasan belajar yang sebelumnya sebesar 61,4 dengan persentase ketuntasan hanya 36%. Peningkatan pada siklus I sebesar 69,6 dengan persentase ketuntasan belajar 60% meningkat 24%, dan pada siklus II meningkat menjadi 75,6 dengan persentase ketuntasan mencapai 88% meningkat sebesar 28%. Dengan demikian pembelajaran melalui metode <em>problem based learning</em> dapat meningkatkan keterempilan menulis deskripsi pada pelajaran Bahasa Indonesia kelas IV SDN 3 Selajambe Kabupaten Kuningan.</span>
The Natural History of Benign Bone Tumors of the Extremities in Asymptomatic Children
Authors: Collier Christopher D. , Nelson Grant B. , Conry Keegan T. , Kosmas Christos , Getty Patrick J. , Liu Raymond W. 
Published: March 2021

Background:
Benign bone tumors are common incidental findings in the pediatric population during radiographic evaluation. Counseling these patients requires reassurance and raises questions about the natural history of these tumors over time. The purpose of this study was to estimate the prevalence and observe the behavior of benign childhood bone tumors in an asymptomatic population.

Methods:
A historical, longitudinal radiographic collection of healthy children was reviewed, which included comprehensive left-sided radiographs of the extremities at yearly intervals. In this study, 262 subjects with 25,555 radiographs were screened for benign bone tumors at a median age of 8 years (range, 0 to 18 years). All potential tumors were reviewed by a multidisciplinary panel, which confirmed the radiographic diagnosis of each lesion, the age at which the lesion first appeared, and the age at which it had resolved. Prevalence rates were calculated using the number of distinct subjects available for each radiographic location and age.

Results:
Thirty-five tumors were identified in 33 subjects, including 19 nonossifying fibromas, 8 enostoses, 6 osteochondromas, and 2 enchondromas. The prevalence rate for all tumors combined increased with age and was 18.9% overall. The overall prevalence rates for specific tumor types were 7.5% for nonossifying fibromas, 5.2% for enostoses, 4.5% for osteochondromas, and 1.8% for enchondromas. Nonossifying fibromas demonstrated a bimodal distribution of prevalence, with a peak at 5 years (10.8%) and another after skeletal maturity (13.3%). The median age at the first appearance for all tumors combined was 9 years (range, 2 to 15 years), but varied by tumor type. Nonossifying fibromas often resolved (7 [37%] of 19), with further resolution possible beyond the last available radiograph. Enostoses, osteochondromas, and enchondromas persisted until the last available radiographs in all subjects.

Conclusions:
The prevalence of benign childhood bone tumors of the extremities was 18.9% in a historical asymptomatic population. Longitudinal radiographs allowed observation of the timing of the first appearance and the potential for resolution for each tumor type. These findings provide unique evidence to answer many commonly encountered questions when counseling patients and their families on benign bone tumors.

Level of Evidence:
Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
STRUCTURE OF TRILOBITE COMMUNITIES ALONG A DELTA-MARINE GRADIENT (LOWER ORDOVICIAN; NORTHWESTERN ARGENTINA)
Authors: SERRA FERNANDA , BALSEIRO DIEGO , VAUCHER ROMAIN , WAISFELD BEATRIZ G. 
Published: March 2021

ABSTRACTThroughout their long history, trilobites occupied various ecological niches, colonizing a wide variety of marine environments. However, the paleoecology of this group is mostly based on shelf–slope environments and less is known about their distribution in marginal environments. To understand how trilobite communities respond to a deltaic influence, we studied changes in the taxonomic composition and structure of a diverse and well-known Lower Ordovician olenid-dominated fauna from the Argentine Cordillera Oriental along a delta–marine gradient. Cluster analysis revealed two distinct associations, and ordination analysis revealed a clear biotic gradient within each. The ecological structure and diversity trends of both associations follow a predictable response to a depth-related gradient. Impoverished communities with a highly nested structure characterize the lower offshore, whereas rich and even communities occur in the upper offshore. The trend towards higher diversity and greater taxonomic turnover in shallower environments corresponds to greater habitat heterogeneity. Towards the other extreme, only the ubiquitous genus Jujuyaspis was a successful colonizer in deltaic settings. This marked contrast with the more diverse and abundant assemblages of fully marine deposits indicates stressful physiological conditions in marginal-marine environments, where alternating and contrasting normal-marine to brackish-water conditions and high input of siliciclastic material were among the key factors controlling the distribution of these early trilobite communities.
Evaluation of Hemolysis Activity of Zerumbone on RBCs and Brine Shrimp Toxicity
Authors: Albaayit Shaymaa Fadhel Abbas , Maharjan Rukesh , Khan Mariam 
Published: March 2021

Zerumbone is a well-known compound having anti-cancer, anti-ulcer, anti-inflammatory and anti-hyperglycemic effects. During its use for the disease treatment, the membrane of erythrocyte can be affected by consumption of this bioactive compound. The current study was the first report of investigation of the hemolytic activities on human erythrocytes and cytotoxic profile of zerumbone. The toxicity of zerumbone on human erythrocytes was determined by in vitro hemolytic assay. Brine shrimp lethality assay was used to evaluate the cytotoxic effect of zerumbone at concentrations 10, 100 and 1000 μg/mL. The human erythrocyte test showed no significant toxicity at low concentrations, whereas hemolytic effect was amplified up to 17.5 % at the highest concentration. The half lethal concentration (LC50) value of zerumbone against brine shrimp was less than 1000 µg /mL (LC50=190 µg/ml) showing the significant toxic nature of this compound. These results provide a baseline in terms of the toxicity of therapeutic formulations from this compound to membrane erythrocytes with a great attention to the highest concentrations, which paves promise for drug development.
Assessment of fundus autofluorescence and adaptive optics high-resolution images in macular disorders
Authors: Ochinciuc Radu , Ochinciuc Uliana , Balta George , Teodoru Adrian , Barri Leila Al , Pac Cristina , Balta Florian , Burcea Marian 
Published: March 2021

Abstract
Purpose

This study analyzed and compared the results of adaptive optics (AO) and fundus autofluorescence (FAF) in various maculopathies.
Methods

The study included four different types of maculopathy: central serous chorioretinopathy (CSC), retinitis pigmentosa (RP), Stargardt disease (STGD) and phototoxic retinopathy. In all four cases cone mosaic and cone density were obtained using AO fundus camera. Further the high resolution images were compared with the FAF and optical coherence tomography (OCT) results.
Results

In CSC, FAF and AO were able to show changes in the macula even two years after the subretinal fluid resorption, as opposed to a normal OCT. The improvement of FAF and cone mosaic appearance was concomitant with the visual acuity growth. Several cone mosaic phenotypes were observed in RP and STGD. In RP the cone density was 24.240cones/mm2 in the center, and decreased to 8.163cones/mm2 in the parafoveolar area. In STGD the cone density was lower in the center, 9.219cones/mm2, and higher at the periphery, 12.594cones/mm2. In the case of phototoxic retinopathy, AO and OCT were more effective than FAF in highlighting the photoreceptor and retinal pigment epithelium lesions.
Conclusions

FAF and AO are very useful tools in macular pathologies examination. FAF can give us a true picture about metabolic changes in the macula while AO allows us to view changes up to the cellular level.
The Evolving Role of Marked Lymph Node Biopsy (MLNB) and Targeted Axillary Dissection (TAD) after Neoadjuvant Chemotherapy (NACT) for Node Positive Breast Cancer: Systematic Review and Pooled Analysis
Authors: Swarnkar Parinita Keshav , Tayeh Salim , Michell Michael , Mokbel Kefah 
Published: March 2021

Abstract

Background: Targeted axillary dissection (TAD) is a new axillary staging technique that consists of the surgical removal of biopsy-proven positive axillary nodes marked (marked lymph node biopsy: MLNB) prior to neoadjuvant chemotherapy (NACT) in addition to the sentinel lymph node biopsy (SLNB). In a meta-analysis of more than 3000 patients, we previously reported a false negative rate (FNR) of 13% using the SLNB alone in this setting. The aim of this systematic review and pooled analysis is to determine FNR of MLNB alone and TAD (MLNB plus SLNB) compared with the gold standard of complete axillary lymph node dissection (cALND).Methods: The PubMed, Cochrane and Google Scholar databases were searched using Mesh relevant terms and free words.Results: A total of 9 studies of 366 patients that met the inclusion criteria evaluating the FNR of MLNB alone were included in the pooled analysis yielding a pooled FNR of 6.28% (95% CI: 3.98-9.43). In 13 studies spanning 521 patients, the addition of SLNB to MLNB (TAD) was associated with a FNR of 5.18% (95% CI: 3.41-7.54) which was not significantly different from that of MLNB alone (p=0.48). Data regarding oncological safety of this approach were lacking. In a separate analysis of all published studies reporting successful identification and surgical retrieval of the MLN, we calculated a pooled success rate of 90.0% (95% CI = 85.1-95.1).Conclusion: The present pooled analysis demonstrates that the FNR associated with MLNB alone or combined with SLNB is acceptably low and both approaches are highly accurate in staging the axilla in patients with node-positive breast cancer after NACT. The SLNB adds minimal new information and therefore it can be safely omitted from TAD. Further research to confirm the oncological safety of this de-escalation approach of axillary surgery is required.Core Tip: MLNB alone and TAD are associated with acceptably low FNRs and represent valid alternatives to cALND in patients with node-positive breast cancer after excellent response to NACT.
Effect of an Information Leaflet on Breast Cancer Screening Participation. A Randomized Controlled Study
Authors: Montero-Moraga Jose Maria , Posso Margarita , Román Marta , Burón Andrea , Sala Maria , Castells Xavier , Macià Francesc 
Published: March 2021

Abstract
Objective: To evaluate the impact of an information leaflet about the risk-benefit balance of breast cancer screening on women’s participation.Methods: This randomized controlled study was conducted within a population-based breast cancer screening program and included women from the catchment areas of two hospitals in Barcelona, Spain. We evaluated women aged 50-69 years invited to screening between September 2019 and January 2020. One hospital attended a population with a lower socioeconomic status than the other. The intervention group received an information leaflet on the benefits and harms of mammography screening. The control group received the usual invitation letter. We compared the participation rate between groups, stratified by hospital and by per-protocol and intention-to-treat analyses. Results: We included 11,119 women in the study: 5,416 in the intervention group and 5,703 in the control group. A total of 36.4% (1,964/5,393) of the women in the intervention group and 37.5% (2,135/5,694) of those in the control group attended screening, respectively. Overall, we found no differences in participation among groups (difference in participation -1.1%; 95% CI; -2.9% to 0.7%, p-value=0.240). In the hospital attending a population with a low socioeconomic status, attendance was lower in the intervention group (-1.4%, 95% CI: -5.7% to -0.03%, p-value=0.029). In the per-protocol analysis, participation was lower in the intervention group (-2.6%, 95% CI: -4.6% to -0.5%, p-value=0.015). Conclusions: Overall participation in our program was unaffected by a new information leaflet on the risk-benefit balance of breast cancer screening. However, participation was lower in certain populations with lower socioeconomic status.
Performance of Quantitative Measures of Multimorbidity: A Population-Based Retrospective Analysis
Authors: Vela Emili , Clèries Montse , Monterde David , Carot-Sans Gerard , Coca Marc , Valero-Bover Damià , Piera-Jiménez Jordi , Eroles Luís García , Sust Pol Pérez 
Published: March 2021

Abstract
Background

Multimorbidity measures are useful for resource planning, patient selection and prioritization, and factor adjustment in clinical practice, research, and benchmarking. We aimed to compare the explanatory performance of the adjusted morbidity group (GMA) index in predicting relevant healthcare outcomes with that of other quantitative measures of multimorbidity.
Methods

The performance of multimorbidity measures was retrospectively assessed on anonymized records of the entire adult population of Catalonia (North-East Spain). Five quantitative measures of multimorbidity were added to a baseline model based on age, gender, and socioeconomic status: the Charlson index score, the count of chronic diseases according to three different proposals (i.e., the QOF, HCUP, and Karolinska institute), and the multimorbidity index score of the GMA tool. Outcomes included all-cause death, total and non-scheduled hospitalization, primary care and ER visits, medication use, admission to a skilled nursing facility for intermediate care, and high expenditure (time frame 2017). The analysis was performed on 10 subpopulations: all adults (i.e., aged > 17 years), people aged > 64 years, people aged > 64 years and institutionalized in a nursing home for long-term care, and people with specific diagnoses (e.g., ischemic heart disease, cirrhosis, dementia, diabetes mellitus, heart failure, chronic kidney disease, and chronic obstructive pulmonary disease). The explanatory performance was assessed using the area under the receiving operating curves (AUC-ROC) (main analysis) and three additional statistics (secondary analysis).
Results

The adult population included 6 224 316 individuals. The addition of any of the multimorbidity measures to the baseline model increased the explanatory performance for all outcomes and subpopulations. All measurements performed better in the general adult population. The GMA index had higher performance and consistency across subpopulations than the rest of multimorbidity measures. The Charlson index stood out on explaining mortality, whereas measures based on exhaustive definitions of chronic diagnostic (e.g., HCUP and GMA) performed better than those using predefined lists of diagnostics (e.g., QOF or the Karolinska proposal).
Conclusions

The addition of multimorbidity measures to models for explaining healthcare outcomes increase the performance. The GMA index has high performance in explaining relevant healthcare outcomes and may be useful for clinical practice, resource planning, and public health research.
Physiological Measurements in Social Acceptance of Self Driving Technologies
Authors: Palatinus Zsolt , Volosin Márta , Csábi Eszter , Hallgató Emese , Hajnal Edina , Lukovics Miklós , Prónay Szabolcs , Ujházi Tamás , Osztobányi Lilla , Szabó Balázs , Králik Tamás , Majo-Petri Zoltan 
Published: March 2021

Abstract
The goal of the present study is to examine the cognitive/physiological correlates of passenger travel experience in autonomously driven transportation systems. We investigated the social acceptance and cognitive aspects of self-driving technology by measuring physiological responses in real-world experimental settings using eye-tracking and EEG measures simultaneously on 17 volunteers. A typical test run included human-driven and autonomous conditions in the same vehicle, in a safe environment. In the spectrum analysis of the eye-tracking data we found significant differences in the complex patterns of eye movements: the structure of movements of different magnitudes were less variable in the autonomous drive condition. EEG data revealed less positive affectivity and slightly higher arousal in the autonomous condition compared to the human-driven condition. Correlates with personality traits are also discussed. These preliminary findings reinforced our initial hypothesis that passenger experience in human and machine navigated conditions entail different physiological and psychological correlates, and those differences are accessible using state of the art in-world measurements. These useful dimensions of passenger experience may serve as a source of information both for the improvement and design of self-navigating technology and for market-related concerns.