bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in microbiological parameters, pH and titratable acidity during the refrigerated and room temperature storage of dahi prepared from the milk of Vechur cows: an indigenous cattle breed of Kerala
Authors: Krishna Ammiti Murali , James Ligimol , Beena Athrayil Kalathil , Rajakumar Sujjalur Nagesha Rao , Mercey Kollannur Aippunny 
Published: December 2021

AbstractVechur cow is an indigenous cattle breed of Kerala listed as a critical breed by FAO. This research communication is related to the hypothesis that the changes occurring in microbiological quality parameters of Vechur cow milk dahi (VCMD) during storage will be superior to other milk and reflective of the traditional concepts of therapeutic properties attributed to Vechur milk. Microbiological quality of the VCMD stored at room (30 ± 1°C) and refrigerated (4 ± 1°C) temperatures in terms of total viable, coliform, yeast and mold and lactococcal counts is reported in this study, together with titratable acidity and pH. Results are compared with cross-bred cow milk dahi (CCMD) as control. On refrigerated storage, despite the comparable initial microbiological quality, VCMD exhibited significantly lower total viable, lactic acid bacteria, yeast and mold counts than CCMD, from the fifth day onwards for the first two parameters and the tenth day onwards for the last parameter. VCMD exhibited significantly higher pH values than CCMD from the fifth day onwards whereas the titratable acidity was significantly lower from the tenth day onwards. Though this study does not delineate the factors contributing towards the lower microbial population observed in VCMD, it provides an impetus to further researches for scientifically validating its traditionally-reported medicinal properties.
Rising early warning signals in affect associated with future changes in depression: a dynamical systems approach
Authors: Curtiss Joshua E. , Mischoulon David , Fisher Lauren B. , Cusin Cristina , Fedor Szymon , Picard Rosalind W. , Pedrelli Paola 
Published: December 2021

AbstractBackgroundPredicting future states of psychopathology such as depressive episodes has been a hallmark initiative in mental health research. Dynamical systems theory has proposed that rises in certain ‘early warning signals’ (EWSs) in time-series data (e.g. auto-correlation, temporal variance, network connectivity) may precede impending changes in disorder severity. The current study investigates whether rises in these EWSs over time are associated with future changes in disorder severity among a group of patients with major depressive disorder (MDD).MethodsThirty-one patients with MDD completed the study, which consisted of daily smartphone-delivered surveys over 8 weeks. Daily positive and negative affect were collected for the time-series analyses. A rolling window approach was used to determine whether rises in auto-correlation of total affect, temporal standard deviation of total affect, and overall network connectivity in individual affect items were predictive of increases in depression symptoms.ResultsResults suggested that rises in auto-correlation were significantly associated with worsening in depression symptoms (r = 0.41, p = 0.02). Results indicated that neither rises in temporal standard deviation (r = −0.23, p = 0.23) nor in network connectivity (r = −0.12, p = 0.59) were associated with changes in depression symptoms.ConclusionsThis study more rigorously examines whether rises in EWSs were associated with future depression symptoms in a larger group of patients with MDD. Results indicated that rises in auto-correlation were the only EWS that was associated with worsening future changes in depression.
Understanding the association between spirituality and mental health outcomes in adolescents in two non-Western countries: Exploring self-control as a potential mediator
Authors: Shroff Delshad M. , Breaux Rosanna , von Suchodoletz Antje 
Published: December 2021

AbstractEmpirical knowledge on what specific aspects of mental health are associated with spirituality is limited, and explanations for the mechanisms underlying this association is scarce. Furthermore, there is limited research on this association among individuals from non-Christian religious backgrounds and non-Western countries. The current study examined relations between spirituality and aspects of mental health in 1,544 adolescents from diverse religious backgrounds in two Eastern countries, India and the United Arab Emirates (UAE). Additionally, we examined mediating and moderating factors. Adolescents (58% female) ages 11–15 years completed a questionnaire on aspects of their mental health, spirituality, and self-control abilities. Results showed that spirituality had a significant positive association with life satisfaction and a significant negative association with internalizing problems, but a non-significant relation with externalizing problems, controlling for age, gender, and socioeconomic status. Self-control completely mediated the association between spirituality and life satisfaction, and this mediational relation was only present for adolescents from the UAE. Results support prior research suggesting positive associations between spirituality and adaptive mental health outcomes and extend these findings to adolescents from diverse religious backgrounds in non-Western countries. These findings have important clinical and policy implications for supporting the role of spirituality in an adolescent’s life.
Functional connectivity based brain signatures of behavioral regulation in children with ADHD, DCD, and ADHD-DCD
Authors: Rohr Christiane S. , Bray Signe L. , Dewey Deborah M. 
Published: December 2021

AbstractBehavioral regulation problems have been associated with daily-life and mental health challenges in children with neurodevelopmental conditions such as attention-deficit/hyperactivity disorder (ADHD) and developmental coordination disorder (DCD). Here, we investigated transdiagnostic brain signatures associated with behavioral regulation. Resting-state fMRI data were collected from 115 children (31 typically developing (TD), 35 ADHD, 21 DCD, 28 ADHD-DCD) aged 7–17 years. Behavioral regulation was measured using the Behavior Rating Inventory of Executive Function and was found to differ between children with ADHD (i.e., children with ADHD and ADHD-DCD) and without ADHD (i.e., TD children and children with DCD). Functional connectivity (FC) maps were computed for 10 regions of interest and FC maps were tested for correlations with behavioral regulation scores. Across the entire sample, greater behavioral regulation problems were associated with stronger negative FC within prefrontal pathways and visual reward pathways, as well as with weaker positive FC in frontostriatal reward pathways. These findings significantly increase our knowledge on FC in children with and without ADHD and highlight the potential of FC as brain-based signatures of behavioral regulation across children with differing neurodevelopmental conditions.
The influence of harshness and unpredictability on female sexual development: Addressing gene–environment interplay using a polygenic score
Authors: Schlomer Gabriel L. , Sun Qi 
Published: December 2021

AbstractRecent developments in the application life history theory to human development indicate two fundamental dimension of the early environment – harshness and unpredictability – are key regulators life history strategies. Few studies have examined the manner with which these dimensions influence development, though age at menarche (AAM) and age at first sexual intercourse have been proposed as possible mechanisms among women. Data from the Avon Longitudinal Study of Parents and Children (N = 3,645) were used to examine direct and indirect effects of harshness (financial difficulties) and unpredictability (paternal transitions) on lifetime and past year sexual partners during adolescence and young adulthood. Genetic confounding was addressed using an AAM polygenic score (PGS) and potential gene-by-environment interactions were also evaluated using the PGS. Path model results showed only harshness was directly related to AAM. Harshness, unpredictability, and AAM were indirectly related to lifetime and past year sexual partner number via age at first sexual intercourse. The PGS did not account for any of the associations and no significant interactions were detected. Implications of these results for developmental models derived from life history theory are discussed as well as the role of PGSs in gene–environment interplay research.
Processing methods and approaches for the analysis of images of the eclipsed solar corona taken during campaigns with the participation of amateur astronomers
Authors: Stoev A. , Stoeva P. , Kuzin S. , Kostov M. , Pertsov A. 
Published: December 2021

AbstractThe increase in the amount of scientific information in heliophysics is related to both quantitative – increasing the number of high-power telescopes and the size of light receivers coupled to them, and qualitative reasons – new modes of observation, large-scale and multiple studies of the solar corona in different ranges, large-scale numerical experiments to simulate the evolution of various processes and formations, etc. The paper discusses the role and importance of methods for processing images of the solar corona, the store of obtained “raw” data and the need to access high-performance computing systems in order to obtain scientific results from the observational experiments, the need of international collaboration and access to the data in the era of increase in the amount of scientific information in heliophysics.
Astronomy Data, Virtual Observatory and Education
Authors: Hasan Priya , Hasan S N 
Published: December 2021

AbstractWe shall present with examples how analysis of astronomy data can be used for an educational purpose to train users in methods of data analysis, statistics, programming skills and research problems. Special reference will be made to our IAU-OAD project ‘Astronomy from Archival Data’ where we are in the process of building a repository of instructional videos and reading material for undergraduate and postgraduate students as well as interested participants. Virtual Observatory tools will also be discussed and applied. As this is an ongoing project, by the time of the conference we will have the projects and work done by students included in our presentation. The material produced can be freely used by the community.
Armenian Astronomical Heritage and Big Data
Authors: Mikayelyan Gor A. , Farmanyan Sona. V. , Mickaelian Areg M. 
Published: December 2021

AbstractAstronomy in Armenia was popular since ancient times and Armenia is rich in its astronomical heritage, such as ancient and medieval Armenian calendars, records of astronomical events by ancient Armenians, the astronomical heritage of the Armenian medieval great thinker Anania Shirakatsi, etc. Armenian astronomical archives have accumulated vast number of photographic plates, films and other careers of observational data. The Digitized Markarian Survey or the First Byurakan Survey, is the most important low-dispersion spectroscopic database. It is one of the rare science items included in UNESCO “Memory of the World” Documentary Heritage list. The Byurakan Astrophysical Observatory (BAO) Plate Archive Project (2015–2021) will result in digitization and storage of some 37,000 astronomical plates and films and in creation of an Electronic Database for further research projects. Based on these data and archives and development of their interoperability, the Armenian Virtual Observatory was created and joined the International Virtual Observatory Alliance.
Volcanic Origin of a Long‐Lived Swarm in the Central Bransfield Basin, Antarctica
Authors: Poli P. , Cabrera L. , Flores M. C. , Báez J. C. , Ammirati J. B. , Vásquez J. , Ruiz S. 
Published: December 2021

AbstractUnderstanding the extensional processes in tectonic context at the transition from continental to oceanic spreading is fundamental to obtain new insights about formations of new oceans. To that scope, we study a large and long‐lived earthquake swarm occurring in 2020–2021 in a back‐arc rift (the Bransfield Basin) south of the South Shetland Islands, Antarctica. We make use of one local seismological station to detect more than 36,000 small earthquakes, occurring from August 2020 to June 2021. Together with the occurrence of earthquakes, we observe a significant, geodetic deformation at a nearby GPS station. By joint interpretation of b‐value, spatiotemporal evolution of seismicity and geodetic deformation, we infer a volcanic origin for this swarm that takes place close to the ridge axis. Our study suggests that beyond the 7 mm/yr deformation reported at the Bransfield Basin ridge, transient deformation episodes localized at the ridge axial volcanic structure also modulate the extension.
Making Waves: Mirror Mode Structures Around Mars Observed by the MAVEN Spacecraft
Authors: Simon Wedlund Cyril , Volwerk Martin , Mazelle Christian , Halekas Jasper , Rojas‐Castillo Diana , Espley Jared , Möstl Christian 
Published: December 2021

AbstractWe present an in‐depth analysis of a time interval when quasi‐linear mirror mode structures were detected by magnetic field and plasma measurements as observed by the NASA/Mars Atmosphere and Volatile EvolutioN spacecraft. We employ ion and electron spectrometers in tandem to support the magnetic field measurements and confirm that the signatures are indeed mirror modes. Wedged against the magnetic pile‐up boundary, the low‐frequency signatures last on average  s with corresponding sizes of the order of 15–30 upstream solar wind proton thermal gyroradii, or 10–20 proton gyroradii in the immediate wake of the quasi‐perpendicular bow shock. Their peak‐to‐peak amplitudes are of the order of 30–35 nT with respect to the background field, and appear as a mixture of dips and peaks, suggesting that they may have been at different stages in their evolution. Situated in a marginally stable plasma with β‖ ∼ 1, we hypothesize that these so‐called magnetic bottles, containing a relatively higher energy and denser ion population with respect to the background plasma, are formed upstream of the spacecraft behind the quasi‐perpendicular shock. These signatures are very reminiscent of magnetic bottles found at other unmagnetized objects such as Venus and comets, also interpreted as mirror modes. Our case study constitutes the first unmistakable identification and characterization of mirror modes at Mars from the joint points of view of magnetic field, electron and ion measurements. Up until now, the lack of high‐temporal resolution plasma measurements has prevented such an in‐depth study.
Depth and Thickness of Tectonic Tremor in the Northeastern Olympic Peninsula
Authors: Ducellier A. , Creager K. C. 
Published: December 2021

AbstractTectonic tremor has been explained as a swarm of low‐frequency earthquakes (LFEs), which are located on a narrow fault at the plate boundary. However, due to the lack of clear impulsive phases in the tremor signal, it is difficult to determine the depth of the tremor source with great precision. The thickness of the tremor region is also not well constrained. The tremor may be located on a narrow fault as the LFEs appear to be, or distributed over a few kilometers wide low shear‐wave velocity layer in the upper oceanic crust, which is thought to be a region with high pore‐fluid pressure. Lag times of peaks in the cross‐correlation of the horizontal and vertical components of tremor seismograms, recorded by small‐aperture arrays in the Olympic Peninsula, Washington, are interpreted to be S minus P times. Tremor depths are estimated from these S minus P times using epicenters from a previous study computed with a multibeam backprojection method. The tremor is located close to the plate boundary in a region no more than 2–3 km thick and is very close to the depths of LFEs. The tremor is distributed over a wider depth range than the LFEs. However, due to the uncertainty on the depth, it is difficult to conclude whether the source of the tremor is located at the top of the subducting oceanic crust, in the lower continental crust just above the plate boundary, or in a narrow zone at the plate boundary.
Updated Surge‐Type Glacier Inventory in the West Kunlun Mountains, Tibetan Plateau, and Implications for Glacier Change
Authors: Guan Weijin , Cao Bo , Pan Baotian , Chen Ran , Shi Menghan , Li Kaiji , Zhao Xuanru , Sun Xiaodong 
Published: December 2021

AbstractGlacier surging is a dynamic instability that affects the flow of some glaciers, modifying the glacier area, surface velocity, and surface elevation. It is also among the major causes of ice dams and glacier lake floods. Previous studies have shown that in the West Kunlun Mountains| (WKM) where a cluster of surge‐type glaciers had been found, the glaciers were relatively stable in recent years. Nevertheless, the surge cycle and its impact on glacier changes on a regional scale are poorly understood. In this study, we updated the surge‐type glacier inventory of the WKM using the detailed changes in glacier length, surface velocity, and surface elevation during the 1972–2020 period using 78 Landsat optical images, 86 Sentinel‐1 synthetic aperture radar (SAR) images, and three digital elevation models of the WKM. The updated results show that among the 423 glaciers in the WKM, 10 are confirmed as surge‐type glaciers, three are likely surge‐type glaciers, and five are possible surge‐type glaciers. Furthermore, these 18 glaciers account for 63% of the total glacier area. During the period analyzed, there were marked changes in the lengths, areas and surface elevations of all surge‐type glaciers, while those of the non‐surge‐type glaciers were relatively stable. These results appear to indicate that the observed regional trends of glaciers in the WKM recently may be related to the existence of surge‐type glaciers. Furthermore, the surge‐type glacier underwent advance after accelerating for 3–4 years, which could be used to forecast when glacier termini may advance and avoid the possible catastrophic damages.
Effects of Reversal of Water Flow in an Arctic Floodplain River on Fluvial Emissions of CO2 and CH4
Authors: Castro‐Morales K. , Canning A. , Körtzinger A. , Göckede M. , Küsel K. , Overholt W. A. , Wichard T. , Redlich S. , Arzberger S. , Kolle O. , Zimov N. 
Published: December 2021

AbstractWhen organic matter from thawed permafrost is released, the sources and sinks of greenhouse gases (GHGs), like carbon dioxide (CO2) and methane (CH4) in Arctic rivers will be influenced in the future. However, the temporal variation, environmental controls, and magnitude of the Arctic riverine GHGs are largely unknown. We measured in situ high temporal resolution concentrations of CO2, CH4, and oxygen (O2) in the Ambolikha River in northeast Siberia between late June and early August 2019. During this period, the largely supersaturated riverine CO2 and CH4 concentrations decreased steadily by 90% and 78%, respectively, while the O2 concentrations increased by 22% and were driven by the decreasing water temperature. Estimated gas fluxes indicate that during late June 2019, significant emissions of CO2 and CH4 were sustained, possibly by external terrestrial sources during flooding, or due to lateral exchange with gas‐rich downstream‐flowing water. In July and early August, the river reversed its flow constantly and limited the water exchange at the site. The composition of dissolved organic matter and microbial communities analyzed in discrete samples also revealed a temporal shift. Furthermore, the cumulative total riverine CO2 emissions (36.8 gC‐CO2 m−2) were nearly five times lower than the CO2 uptake at the adjacent floodplain. Emissions of riverine CH4 (0.21 gC‐CH4 m−2) were 16 times lower than the floodplain CH4 emissions. Our study revealed that the hydraulic connectivity with the land in the late freshet, and reversing flow directions in Arctic streams in summer, regulate riverine carbon replenishment and emissions.
CDH1 germline variants are enriched in patients with colorectal cancer, gastric cancer, and breast cancer
Authors: Adib Elio , El Zarif Talal , Nassar Amin H. , Akl Elie W. , Abou Alaiwi Sarah , Mouhieddine Tarek H. , Esplin Edward D. , Hatchell Kathryn , Nielsen Sarah M. , Rana Huma Q. , Choueiri Toni K. , Kwiatkowski David J. , Sonpavde Guru 
Published: December 2021

Abstract
Background and aims
CDH1 germline variants have been linked to heritability in diffuse gastric (DGC) and lobular breast cancer (LBC). Studies have not yet assessed whether CDH1 is a cancer-susceptibility gene in other cancers. Herein, we mapped the landscape of pathogenic and likely pathogenic (P/LP) germline variants in CDH1 across various cancers and ethnicities.

Methods
We evaluated CDH1 germline P/LP variants in 212,944 patients at one CLIA-certified laboratory (Invitae) and described their frequency in 7 cancer types. We screened for CDH1 variant enrichment in each cancer relative to a cancer-free population from The Genome Aggregation Database version 3 (gnomADv3).

Results
CDH1 P/LP variants were identified in 141 patients, most commonly in patients with DGC (27/408, 6.6%) followed by colorectal signet-ring cell cancer (CSRCC; 3/79, 3.8%), gastric cancer (56/2756, 2%), and LBC (22/6809, 0.3%). CDH1 P/LP variants were enriched in specific ethnic populations with breast cancer, gastric cancer, CRC, LBC, DGC, and CSRCC compared to matched ethnicities from gnomADv3.

Conclusion
We report for the first time the prevalence of P/LP CDH1 variants across several cancers and show significant enrichment in CDH1 P/LP variants for patients with CSRCC, DGC, and LBC across various ethnicities. Future prospective studies are warranted to validate these findings.
A summary-statistics-based approach to examine the role of serotonin transporter promoter tandem repeat polymorphism in psychiatric phenotypes
Authors: Majumdar Arunabha , Patel Preksha , Pasaniuc Bogdan , Ophoff Roel A. 
Published: December 2021

AbstractIn genetic studies of psychiatric disorders in the pre-genome-wide association study (GWAS) era, one of the most commonly studied loci is the serotonin transporter (SLC6A4) promoter polymorphism, a 43-base-pair insertion/deletion polymorphism in the promoter region (5-HTTLPR). The genetic association signals between 5-HTTLPR and psychiatric phenotypes, however, have been inconsistent across many studies. Since the polymorphism cannot be tested via available SNP arrays, we had previously proposed an efficient machine learning algorithm to predict the genotypes of 5-HTTLPR based on the genotypes of eight nearby SNPs, which requires access to individual-level genotype and phenotype data. To utilize the advantage of publicly available GWAS summary statistics obtained from studies with very large sample sizes, we develop a GWAS summary-statistics-based approach for testing the variable number of tandem repeat (VNTR) associations with various phenotypes. We first cross-verify the accuracy of the summary-statistics-based approach for 61 phenotypes in the UK Biobank. Since we observed a strong similarity between the predicted individual-level 5-HTTLPR genotype-based approach and the summary-statistics-based approach, we applied our method to the available neurobehavioral GWAS summary statistics data obtained from large-scale GWAS. We found no genome-wide significant evidence for association between 5-HTTLPR and any of the neurobehavioral traits. We did observe, however, genome-wide significant evidence for association between this locus and human adult height, BMI, and total cholesterol. Our summary-statistics-based approach provides a systematic way to examine the role of VNTRs and related types of genetic polymorphisms in disease risk and trait susceptibility of phenotypes for which large-scale GWAS summary statistics data are available.