bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breathing variability during propofol/remifentanil procedural sedation with a single additional dose of midazolam or s-ketamine: a prospective observational study
Authors: van den Bosch O. F. C. , Alvarez-Jimenez R. , Schet S. G. , Delfsma K. , Loer S. A. 
Published: November 2021

Abstract
Purpose
Regulation of spontaneous breathing is highly complex and may be influenced by drugs administered during the perioperative period. Because of their different pharmacological properties we hypothesized that midazolam and s-ketamine exert different effects on the variability of minute ventilation (MV), tidal volume (TV) and respiratory rate (RR).

Methods
Patients undergoing procedural sedation (PSA) with propofol and remifentanil received a single dose of midazolam (1–3 mg, n = 10) or s-ketamine (10–25 mg, n = 10). We used non-invasive impedance-based respiratory volume monitoring to record RR as well as changes in TV and MV. Variability of these three parameters was calculated as coefficients of variation.

Results
TV and MV decreased during PSA to a comparable extent in both groups, whereas there was no significant change in RR. In line with our hypothesis we observed marked differences in breathing variability. The variability of MV (– 47.5% ± 24.8%, p = 0.011), TV (– 42.1% ± 30.2%, p = 0.003), and RR (– 28.5% ± 29.3%, p = 0.011) was significantly reduced in patients receiving midazolam. In contrast, variability remained unchanged in patients receiving s-ketamine (MV + 16% ± 45.2%, p = 0.182; TV +12% ± 47.7%, p = 0.390; RR +39% ± 65.2%, p = 0.129). After termination of PSA breathing variables returned to baseline values.

Conclusions
While midazolam reduces respiratory variability in spontaneously breathing patients undergoing procedural sedation, s-ketamine preserves variability suggesting different effects on the regulation of spontaneous breathing.
Clumped or regular? the role of thinning pattern on pine growth and soil water content in dense Aleppo pine post-fire stands
Authors: Turrión Diana , Fornieles Francisco , Bautista Susana 
Published: November 2021

AbstractThe development of silvicultural practices that seek to promote structural heterogeneity is increasingly demanded. This work investigates the effect of thinning spatial pattern on the response to pre-commercial thinning of dense Aleppo pine post-fire stands. On three replicated experimental sites in SE Spain, we applied the following treatments: 600 trees/ha, regular thinning pattern (600R), with residual trees evenly spaced; 600 trees/ha, aggregated thinning pattern (600A), with residual pines arranged in clumps of ∽25 trees with a local within-clump density of 2500 trees/ha; and control treatment, with no thinning applied (> 20,000 trees/ha). We assessed treatment effects on pine growth, size-growth relationships, soil water content, and understory vegetation over the first three years after thinning application. Both regular and aggregated thinning pattern similarly increased pine radial growth. In general, dbh growth rates in response to thinning were faster for smaller trees than for larger trees. The growth rate of pine height was higher for 600R and control than for 600A, indicating a positive effect on height of both low and very high pine densities. We found a near-term positive effect of aggregated pattern on water availability at the stand level, mostly resulting from enhanced soil water content in the canopy gaps. For both thinning patterns, the recovery of understory vegetation was dominated by resprouter species. This study highlights the potential of aggregated thinning patterns to enhance the complexity and heterogeneity of the pine stands without compromising pine growth, which could be of great use to managing pine forests in Mediterranean areas.
Reverse-correlation reveals internal error-corrections during information-seeking
Authors: Weise Lorenz , Forster Saskia D. , Gauggel Siegfried 
Published: November 2021

AbstractIn the area of metacognition research, different methods have been used to study participants’ subjective sense of confidence in their choices. Among the most often used methods are explicit reports of subjective confidence, post-decision wagering and measuring additional info-seeking behavior. While all three methods are thought to measure confidence, they differ greatly in terms of practical execution and theoretical foundation. The method of reverse correlation has previously been used to determine which aspects of the stimulus influence decisions and confidence judgments. Here we compare the three methods of confidence assessment using reverse correlation analysis. Explicit reports and post-decision wagering revealed a positive association of stimulus information with choices and reduced decision weights for low-confidence trials. When confidence was assessed using the info-seeking method, low-confidence trials showed an inverted association with primary stimulus information. Using modelling of the behavioral data, we show how the reverse correlation results of all three methods can be explained by a simple model of confidence when internal error-corrections are allowed during seeking of additional information.
Treatment status of extremely premature infants with gestational age < 28 weeks in a Chinese perinatal center from 2010 to 2019
Authors: Zhang Wen-Wen , Yu Yong-Hui , Dong Xiao-Yu , Reddy Simmy 
Published: November 2021

Abstract
Background
There is a paucity of studies conducted in China on the outcomes of all live-birth extremely premature infants (EPIs) and there is no unified recommendation on the active treatment of the minimum gestational age in the field of perinatal medicine in China. We aimed to investigate the current treatment situation of EPIs and to provide evidence for formulating reasonable treatment recommendations.

Methods
We established a real-world ambispective cohort study of all live births in delivery rooms with gestational age (GA) between 24+0 and 27+6 weeks from 2010 to 2019.

Results
Of the 1163 EPIs included in our study, 241 (20.7%) survived, while 849 (73.0%) died in the delivery room and 73 (6.3%) died in the neonatal intensive care unit. Among all included EPIs, 862 (74.1%) died from withholding or withdrawal of care. Regardless of stratification according to GA or birth weight, the proportion of total mortality attributable to withdrawal of care is high. For infants with the GA of 24 weeks, active treatment did not extend their survival time (P = 0.224). The survival time without severe morbidity of the active treatment was significantly longer than that of withdrawing care for infants older than 25 weeks (P < 0.001). Over time, the survival rate improved, and the withdrawal of care caused by socioeconomic factors and primary nonintervention were reduced significantly (P < 0.001).

Conclusions
The mortality rate of EPIs is still high. Withdrawal of care is common for EPIs with smaller GA, especially in the delivery room. It is necessary to use a multi-center, large sample of real-world data to find the survival limit of active treatment based on our treatment capabilities.
Molecular control to salt tolerance mechanisms of woody plants: recent achievements and perspectives
Authors: Llanes Analia , Palchetti María Virginia , Vilo Claudia , Ibañez Cristian 
Published: November 2021

AbstractKey messageWoody plants have salt-tolerant mechanisms similar to those developed by non-woody plants. Among others, compartmentalization of ions, production of compatible solutes, synthesis of specific proteins and metabolites, and induction of transcriptional factors are the most relevant. Woody plant-associated microbial interactions as well as naturally stress-adapted trees are resources that deserve to be deepened to fully understand the tolerance mechanisms.ContextThe high variability of salinity responses found in woody plants implies a high potentiality for germplasm selection and breeding. Salt tolerance mechanisms of plants are regulated by numerous genes, which control ion homeostasis, production of compatible solutes and specific proteins, and activation or repression of specific transcription factors. Despite the fact that numerous studies have been done on herbaceous model plants, knowledge about salt tolerance mechanisms in woody plants is still scarce.AimsThe present review critically evaluates molecular control of salt tolerance mechanisms of woody plants, focusing on the regulation and compartmentalization of ions, production of compatible solutes, activation of transcription factors, and differential expression of stress response-related proteins, including omics-based approaches and the role of plant-microbial interactions. The potential identification of genes from naturally stress-adapted woody plants and the integration of the massive omics data are also discussed.ConclusionIn woody plants, salt tolerance mechanisms seem not to diverge to those identified in non-woody plants. More comparative studies between woody and non-woody salt tolerance plants will be relevant to identify potential molecular mechanisms specifically developed for wood plants. In this sense, the activation of metabolic pathways and molecular networks by novel genetic engineering techniques is key to establish strategies to improve the salt tolerance in woody plant species and to contribute to more sustainable agricultural and forestry systems.
Microstructure and mechanical properties of melt-grown alumina-mullite/glass composites fabricated by directed laser deposition
Authors: Zhao Dake , Wu Dongjiang , Shi Jing , Niu Fangyong , Ma Guangyi 
Published: November 2021

AbstractMelt-grown alumina-based composites are receiving increasing attention due to their potential for aerospace applications; however, the rapid preparation of high-performance components remains a challenge. Herein, a novel route for 3D printing dense (< 99.4%) high-performance melt-grown alumina-mullite/glass composites using directed laser deposition (DLD) is proposed. Key issues on the composites, including phase composition, microstructure formation/evolution, densification, and mechanical properties, are systematically investigated. The toughening and strengthening mechanisms are analyzed using classical fracture mechanics, Griffith strength theory, and solid/glass interface infiltration theory. It is demonstrated that the composites are composed of corundum, mullite, and glass, or corundum and glass. With the increase of alumina content in the initial powder, corundum grains gradually evolve from near-equiaxed dendrite to columnar dendrite and cellular structures due to the weakening of constitutional undercooling and small nucleation undercooling. The microhardness and fracture toughness are the highest at 92.5 mol% alumina, with 18.39±0.38 GPa and 3.07±0.13 MPa·m1/2, respectively. The maximum strength is 310.1±36.5 MPa at 95 mol% alumina. Strength enhancement is attributed to the improved densification due to the trace silica doping and the relief of residual stresses. The method unravels the potential of preparing dense high-performance melt-grown alumina-based composites by the DLD technology.
Characterization of ultrafine-grained copper joints acquired by rotary friction welding
Authors: Ciemiorek M. , Morawiński Ł. , Jasiński C. , Orłowska M. , Chmielewski T. , Olejnik L. , Lewandowska M. 
Published: November 2021

Abstract
Copper rods with ultrafine-grained microstructure, obtained by multi-turn ECAP processing, were subjected to Direct Drive Rotary Friction Welding using various processing parameters, such as rotational speed and pressure, which resulted in different energy and heat input. Even though friction welding is a high energy process, by a proper selection of processing parameters it was possible to maintain grain size at around 0.7 µm in the weld zone and preserve the UFG microstructure. These microstructural features translated into mechanical properties: the YS for those specimens was around 330 MPa. Processing parameters that resulted in a larger heat input caused an increase in grain size to around 2 µm; this, however, increased ductility and led to a uniform elongation exceeding 5%. Corrosion resistance in the stir zone increased, as was evident in the higher open circuit potential and higher corrosion potential in comparison with base material; the observed differences were about 50 mV. These changes can be explained by the higher fraction of HAGBs in the SZ.
A regenerative 3D scaffold for inguinal hernia repair. MR imaging and histological cross evidence. Qualitative study
Authors: Amato Giuseppe , Agrusa Antonino , Puleio Roberto , Micci Giuseppe , Cassata Giovanni , Cicero Luca , Di Buono Giuseppe , Calò Pietro Giorgio , Galia Massimo , Romano Giorgio 
Published: November 2021

Abstract

Background
Inguinal hernia is a degenerative disease occurring in a high motile surround. Stopping degeneration and promoting tissue regeneration should be the treatment goal. Groin hernias are conventionally managed with static flat meshes, mostly fixated to the delicate inguinal environment. Far from a regenerative effect, the biologic response of conventional hernia meshes is characterized by a foreign body reaction leading to a stiff/shrunken scar plate, which is often the source of unpleasant complications. Recently, a newly engineered 3D device for inguinal hernia repair – ProFlor-has been developed to produce a regenerative biological response. Unlike conventional hernia meshes, this regenerative 3D hernia scaffold seems to demonstrate suitable features for a pathogenetical and physiological coherent treatment of the disease. The aim of this manuscript is to cross evidence these features through magnetic resonance imaging (MRI) and histology.

Study design
The biological response of ProFlor at three defined post-implantation stages has been evaluated through MRI signal intensity and compared to neighbouring muscles and fat. As additional proof, histology of tissue specimens excised at the same post-implantation periods from porcine models during an experimental attempt were also evaluated.

Results
MRI of newly ingrown tissue in ProFlor demonstrated similar signal intensity of muscles while fat tissue showed remarkably higher values. These data matched with the histology of ProFlor biopsies excised from pigs.

Conclusions
The motile compliance to groin movements of ProFlor appears to induce a probiotic biologic response comparable to a regenerative scaffold, allowing to physiologically resolve the degenerative source of inguinal hernia disease.

Highlights
Monetizing Legal Assets: Social and Economic Benefits of Third-Party Dispute Finance in Asia
Authors: Khong Cheng-Yee 
Published: November 2021

AbstractThis article explains third-party dispute finance, including practical issues relating to the funding process and how to choose a funder. It examines some of the social benefits of funding and its importance in an economic downturn, and looks at some of the risks of dispute finance. It also considers the regulation of dispute finance in various Asian jurisdictions, as well as recent industry trends, including the use of dispute funding by well-resourced corporates and dispute-finance products for companies. It explains funding for insolvency-related claims and funding for the enforcement of awards and judgments. Finally, it provides two case-studies in which funding provided access to justice and enabled the funded party to recover a non-performing loan in multiple jurisdictions.
The K-property for some unique equilibrium states in flows and homeomorphisms
Authors: CALL BENJAMIN 
Published: November 2021

AbstractWe set out some general criteria to prove the K-property, refining the assumptions used in an earlier paper for the flow case, and introducing the analogous discrete-time result. We also introduce one-sided
$\lambda $
-decompositions, as well as multiple techniques for checking the pressure gap required to show the K-property. We apply our results to the family of Mañé diffeomorphisms and the Katok map. Our argument builds on the orbit decomposition theory of Climenhaga and Thompson.
CHINESE CAPITAL GOES GLOBAL: THE BELT AND ROAD INITIATIVE AND BEYOND
Authors: Shi Weiyi , Ye Min 
Published: November 2021

AbstractThe Belt and Road Initiative (BRI), and China's state-led model for economic globalization more generally, have attracted controversy: Are state-led overseas investment and lending driven by strategic motives or market rationale? How have the recipient economies reacted to the influx of Chinese capital? This special issue sheds light on these questions by first outlining the fragmented state system driving the BRI, a system featuring both Beijing's strategic logic at the top and market considerations in policy implementation. The role of the state is unpacked further in China's globalizing coal industry and in the growth of Chinese industry export to BRI countries. Finally, the issue explores the mechanisms behind public backlash and political pushback facing China in Zambia and Australia. As the COVID-19 pandemic continues to shift China's relationship with the world, this special issue contributes to a more nuanced understanding of themodus operandiof Chinese capital going global.
PEDDLING OR PERSUADING: CHINA'S ECONOMIC STATECRAFT IN AUSTRALIA
Authors: Wong Audrye 
Published: November 2021

AbstractWith the globalization of Chinese capital, economic statecraft has become an increasingly prominent component of China's foreign policy. In this article, I examine China's use of economic inducements in developed democracies, a topic of growing concern for policymakers, focusing on the case of Australia. I show how Beijing's attempts to coopt public voices and influence Australia's foreign policy using non-transparent political donations and academic funding generated a strong backlash. At the same time, economic interdependence has provided a buffering effect, with key domestic actors in Australia advocating for cooperative relations, although this effect can in turn be limited by Beijing's coercive economic tactics. My findings underline the reputational costs of certain approaches to economic statecraft, the value of building supportive coalitions, and the challenges faced by China's authoritarian state capitalist model. They also highlight the impacts of globalized Chinese capital in developed democracies, including the resilience and vulnerabilities inherent in democratic political processes.
Dimensions of temperament and character as predictors of antidepressant discontinuation, response and adverse reactions during treatment with nortriptyline and escitalopram
Authors: Köhler-Forsberg Ole , Keers Robert , Uher Rudolf , Hauser Joanna , Maier Wolfgang , Rietschel Marcella , McGuffin Peter , Farmer Anne E. , Aitchison Katherine J. , Mors Ole 
Published: November 2021

AbstractBackgroundPersonality traits may predict antidepressant discontinuation and response. However, previous studies were rather small, only explored a few personality traits and did not include adverse drug effects nor the interdependency between antidepressant discontinuation patterns and response.MethodsGENDEP included 589 patients with unipolar moderate-severe depression treated with escitalopram or nortriptyline for 12 weeks. Seven personality dimensions were measured using the self-reported 240-item Temperament and Character Inventory-Revised (TCI-R). We applied Cox proportional models to study discontinuation patterns, logistic and linear regression to investigate response and remission after 8 and 12 weeks, and mixed-effects linear models regarding time-varying treatment response and adverse drug reactions.ResultsLow harm avoidance, low cooperativeness, high self-transcendence and high novelty seeking were associated with higher risks for antidepressant discontinuation, independent of depressed mood, adverse drug reactions, drug, sex and age. Regression analyses showed that higher novelty seeking and cooperativeness scores were associated with a greater likelihood of response and remission after 8 and 12 weeks, respectively, but we found no correlations with response in the mixed-effects models. Only high harm avoidance was associated with more self-reported adverse effects.ConclusionsThis study, representing the largest investigation between several personality traits and response to two different antidepressants, suggests that correlations between personality traits and antidepressant treatment response may be confounded by differential rates of discontinuation. Future trials on personality in the treatment of depression need to consider this interdependency and study whether interventions aiming at improving compliance for some personality types may improve response to antidepressants.
The long-term course of cognition in bipolar disorder: a systematic review and meta-analysis of patient-control differences in test-score changes
Authors: Samamé Cecilia , Cattaneo Brenda Lucía , Richaud María Cristina , Strejilevich Sergio , Aprahamian Ivan 
Published: November 2021

AbstractNeuropsychological impairment represents a key aspect of bipolar disorder (BD) that is evident even in early-course patients and is a strong predictor of functional outcomes among those affected. Previous meta-analyses of longitudinal studies suggest that BD-related cognitive deficits may not progress along the course of the disorder. However, short test-retest periods were used in most primary studies and comparisons with healthy controls were limited. The aim of this review was to synthesize the findings of research reports comparing long-term neurocognitive trajectories between BD patients and healthy individuals. PubMed, PsycINFO, and Scopus databases were searched from inception through July 2021. Publications were considered for inclusion if they reported cognitive test scores of BD patients and healthy controls at two different time points, with a minimum test-retest interval of 5 years. Fifteen studies compared the long-term course of cognition in BD patients with that of healthy controls. Ten of these were included in the quantitative analysis and involved 540 BD patients and 644 healthy individuals (mean follow-up period: 8.9 years). Patient-control effect sizes (standardized mean differences) were calculated for test-score changes in 24 neuropsychological variables and combined by means of meta-analytic procedures. No significant differences were found between patients and controls regarding long-term cognitive outcomes. These findings are consistent with previous shorter-term longitudinal meta-analyses and do not provide evidence for progressive cognitive deterioration in most bipolar individuals. Future studies should address the longitudinal course of cognition in different subgroups of BD patients and its prognostic and therapeutic value.
The language of suppression: Muslims, migrant workers, and India's response to COVID-19
Authors: Nagar Ila 
Published: November 2021

AbstractWhen a society faces a moment of crisis, its language can mirror, expose, and reinforce societal chaos and fault lines. As India came to terms with COVID-19, the coronavirus’ impacts on different populations exposed and widened India's deep social, economic, and religious divides. This article studies the language of India's response to COVID-19 surrounding three major events that occurred in the early months of the pandemic: the janta curfew, the Tablighi Jamaat incident, and the migrant worker crisis. Through an analysis of media reports, speeches made by Prime Minister Narendra Modi, and representations on social media, we see how forms of linguistic trickery—silence, presuppositions, accommodations, othering, dog whistling, and povertyism—were used to suppress, harm, and marginalize two minority groups: Muslims and migrant workers. This article demonstrates how those in power use language to reflect, shape, and reinforce meaning, social hierarchies, and marginalization in a time of crisis. (Linguistic trickery, othering, silence, presupposition, accommodation, dog whistling, povertyism)