bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inotuzumab Ozogamicin Monotherapy as an Outpatient Salvage Treatment in Relapsed Refractory B-Cell Acute Lymphoblastic Leukemia: Compassionate Access
Authors: Radhakrishnan Vivek S. , Modak Ketan , Bhave Saurabh J. , Kumar Jeevan , Roychowdhury Mita , Ghosh Manik , Parihar Mayur , Arora Neeraj , Mishra Deepak K. , Nair Reena , Chandy Mammen 
Published: August 2021

AbstractRelapsed and refractory (RR) acute lymphoblastic leukemia (ALL) poses unique and difficult challenges to a practicing clinician in India where access to novel immunotherapies is limited. Between 2017 and 2020, eight patients with B-cell ALL at our center received inotuzumab ozogamicin (IO) monotherapy on compassionate access, as salvage therapy after at least two lines of conventional therapy failure, and most often as outpatient infusion. Eight patients (21–60 years, three females) received IO. Three patients had morphologic relapse and five patients reported persistent measurable residual disease (MRD). The best response on IO therapy achieved was negative MRD in six of seven patients and complete response (CR) with persistent MRD in one. One patient died (intracranial hemorrhage) before completion of first cycle. All responding patients were transplant eligible and four patients (57%) underwent allogeneic hematopoietic cell transplantation (Allo-HCT). Median follow-up of this cohort is 9 months (4–29.6 months), four patients (57%) are alive as stable with negative MRD. No significant infusion reactions occurred during therapy. Three patients developed grades III and IV neutropenia, two patients showed grade III transaminitis, and two patients developed post-HCT severe sinusoidal obstruction syndrome (SOS). IO is a feasible outpatient based salvage therapy to improve the remission status in RR B-cell ALL.
Comparative analysis of variations in the critical frequency of the ionospheric F2 layer under different heliogeophysical conditions at the Moscow station
Authors: Ivannikova A G , Kotonayeva N G 
Published: August 2021

Abstract
Results of the statistical analysis of variations of critical frequency of a layer of F2 of an ionosphere at various levels of solar and geomagnetic activity are presented by data from the station Moscow from 1957 to 2019. Optimum intervals of division into levels of geomagnetic activity are experimentally found. The need to divide solar activity into low and high in ionospheric research has been proved. The effect of solar and geomagnetic activity on the occurrence of periodic positive and negative deviations of the critical frequency of the ionosphere F2 layer from the median, calculated for 27 previous days in various seasons, is shown. It has been shown that the daily course of deviations at a high level of geomagnetic activity for negative deviations ceases to be pronounced, unlike positive deviations.
GPS L1 signals absorption in high-latitude lower ionosphere during severe geomagnetic storm in June 2015
Authors: Andreev V E , Gubenko V N , Kirillovich I A 
Published: August 2021

Abstract
Based on the results of an analysis of FORMOSAT-3/COSMIC radio occultation measurements, the absorption of DM-radio waves (wavelength ∼19 cm) in the lower high-latitude ionosphere of the Earth was detected. The maximum absorption value is ∼3 dB in the range from ∼60 to ∼90 km and, in some cases, it reaches ∼10 dB at altitudes from ∼90 to ∼95 km. A method for determining the vertical profiles of the absorption coefficient by solving the inverse problem of radiosonding in the Earth’s lower ionosphere is proposed. The absorption layers, caused by powerful bursts of X-ray radiation and strong changes in geomagnetic conditions during the storm, were reliably identified in individual sessions. It was found that, at altitudes from ∼90 to ∼100 km, the value of the absorption coefficient of DM-radio waves reached values (5.69 ± 1.35)·10−3 dB/km.
Monitoring of Norilsk TPP-3 fuel tanks dynamics using Sentinel-1 SAR data
Authors: Zakharov A , Zakharova L 
Published: August 2021

Abstract
The results of interferometric processing and analysis of European spaceborne synthetic aperture radar (SAR) Sentinel-1 acquired over the territory of Norilsk thermal power plant TPP-3 are presented. Radar interferograms created cover both cold season of 2019-2020 and warm season of 2020 including catastrophic event- the rupture of the tank with diesel fuel. Owing to high temporal stability of radar signals backscatter from the surface of TPP-3 territory on the time interval between repeated observations the monitoring of the stability of fuel tanks and adjacent territory using classical radar interferometry technique was conducted. It was discovered that the relative location of all four TPP-3 reservoirs and adjacent territory is stable within the 2-3 mm band on all the observation intervals. We may suppose that the fuel tank rupture was not caused by the dynamics of the study area as a consequence of permafrost thaw.
Improving the effectiveness of monitoring of dangerous meteorological phenomena
Authors: Ivannikov D A 
Published: August 2021

Abstract
Three approaches to improving the effectiveness of monitoring of dangerous meteorological phenomena are considered. The first one is based on the modernization of incoherent weather radar on the example of MRL-5 for the possibility of estimating the width of the doppler spectrum by implementing algorithms for pseudo-coherent frequency signal processing with subsampling. Mathematical modeling is carried out, confirming the technical feasibility of the algorithms. On the basis of mathematical analysis, expressions are obtained and graphs of the suppression coefficient of the moving target selection system are presented. The second approach offers a way to improve the efficiency of monitoring for turbulence. An algorithm for detecting zones of increased turbulence and estimating their parameters is proposed. Equations are obtained, on the basis of which algorithms for detecting and estimating the normalized width of the doppler spectrum of zones of increased turbulence, as well as determining the power level of the reflected signals, are synthesized. The third approach describes a way to improve the efficiency of thunderstorm detection and the accuracy of their localization by supplementing the MRL-5 with magnetometric equipment. An example of the implementation and brief technical specifications are given.
Preliminary analysis of experimental cross-polarization images from polarimetric aircraft synthetic aperture radar of P-band
Authors: Kalinkevich A A , Kutuza B G , Yu Manakov V , Egorov D P , Plyushchev V A 
Published: August 2021

Abstract
An analysis of polarimetric synthetic aperture radar (SAR) space observations usage for measuring Faraday rotation angle of plane-polarized electromagnetic radiation on the satellite-Earth-satellite route and calibrating the radar is performed. It is shown that technical characteristics of SAR, the radar movement during the survey and features of electromagnetic waves reflection from the rough Earth’s surface, as well as small-scale ionospheric inhomogeneities affect the results of comparison the radar images at HV and VH cross-polarizations. As a result, there is a problem of SAR signal polarization plane Faraday rotation angle measuring accuracy, which is needed for proper calibration of linearly polarized polarimetric long-wave band SAR using methods proposed by soviet and foreign specialists. Currently, there are no studies of Earth’s surfaces reflection properties carried out by means of space-based long-wave band polarimetric synthesized aperture radars at HV and VH polarizations. At the same time, the authors are not aware of any works, in which the reciprocity principle of cross-polarized HV and VH radar images is analyzed. An attempt to use aircraft P-band radar images at HV and VH polarizations for studying the reciprocity principle is performed in this work.
Forming a short acoustic signal to study the underwater environment
Authors: Konovalov R S , Konovalov S I , Kuz’menko A G , Pavlov I V , Tsaplev V M 
Published: August 2021

Abstract
Piezoelectric transducers (PET) are widely used as emitters and receivers of acoustic signals to solve a great number of problems related to the study of the World Ocean. Providing the ability to operate the PET in the mode of short-sounding pulse radiation allows increasing the resolution of the remote sensing equipment of the aquatic environment. At the same time, a number of tasks require the use of non-directional emitters, for example, in the form of a thin-walled sphere. It is of interest to study the possibility of obtaining a short probing signal at the output of this type of PET. The paper considers the pulse mode of operation of a non-directional thin-walled spherical emitter excited by a short electrical signal. The research is based on the application of the method of equivalent circuits of the PET and the Fourier spectral method. The durations and amplitudes of the probing pulses emitted by the PEP are estimated. The results obtained may be applied to the design of equipment for underwater research.
Using Android smartphones with dual-frequency multi-GNSS receiver to measure the total electron content of the ionosphere
Authors: Kogogin D A , Nasyrov I A , Maksimov D S , Zagretdinov R V 
Published: August 2021

Abstract
The results of raw GNSS data recorded using a Xiaomi Mi 8 android smartphone equipped with a dual-frequency GNSS module BCM47755 capable of receiving and processing signals from the GPS, Galileo, QZSS systems in the L1 and L5 frequency sub-bands are presented in the paper. The indices of ionospheric activity that as variations in the relative slant total electron content, the rate of total electron content, the rate of total electron content index, root-mean-square deviation of relative slant total electron content on the base of raw GNSS data are calculated. A comparison study of the data obtained with the data from the KZN2 station of the International GNSS Service network, equipped with a professional GNSS receiver of a geodetic class is carried out. It is shown that the median value of signal strength at frequencies L1 and L5 for the data obtained from the satellites G08, G10, G27, G32, E09 on the Xiaomi Mi 8 smartphone is ≈ 5-25% lower than data from the KZN2 station. The indices of ionospheric activity registered by the Xiaomi Mi 8 smartphone have a higher signal-to-noise ratio in comparison with the data of the KZN2 station. Median levels of variations of the relative slant TEC, ROT, ROTI, and RMSTEC obtained by the Trimble Alloy receiver at KZN2 station were 45÷70% lower than that for the Xiaomi Mi 8 smartphone. Nonetheless, the possibility of registering the indices of ionospheric activity such as relative slant total electron content and others based on dual-frequency raw GNSS measurements (primarily carrier-phase and pseudorange) of GNSS signals received by smartphones opens up prospects for attracting as wide a community as possible for collecting GNSS data and monitoring the ionosphere.
User Perception of the Existence of Arena Youth Park as a Green Open Space in Jambi City
Authors: Utami S , Hidayah R 
Published: August 2021

Abstract
Green Open Space (GOS) is one of the conditions for the formation of a good and healthy city that is beneficial for humans and the environment around the city. In Jambi City Arena Youth Park is one of the GOS and a place for people to do activities such as sports, picnics with family, playgrounds and other activities in Jambi City. This paper aims to determine the user’s perception of Arena Youth Park as a green open space. The method used in this research is quantitative qualitative. The results showed that the typology of green open space in Arena Youth Park was optimal, most of them had met the standards in the Minister of Public Works Regulation No.05/PRT/M/2008. Users of Arena Youth Park tend to engage in recreational activities with a proportion of 49.1%. The variable that has a significant effect on the existence of Arena Youth Park as GOS is Arena Youth Park which affects air quality in cities. As many as 73% of Arena Youth Park users agree that Arena Youth Park is a green open space in Jambi City. With three aspects, namely ecological (72%), socio-cultural (73%) and economic (75%).
Philanthropy in Settlement Infrastructure Development
Authors: Rochani A , Yuliastuti N , Sudarwanto B 
Published: August 2021

Abstract
Current settlements development face problems of funding sources for limited infrastructure construction. Especially during the Covid 19 pandemic, where state revenue as the main basis for infrastructure funding could not reach the expected target. It requires blended financing sources that do not only rely on the ability of state funding but also alternative sources of funding, one of which is in the form of philanthropy, an effort to help others which are manifested by a social charity in the form of funds or something else. This research applied a descriptive-analytic method to explore various philanthropic phenomena developed in Indonesia. The results show that philanthropy has been developing for a long time and has become one of the roots of the social life of the Indonesian people. Philanthropy grows from the spirit of togetherness in the community and encourages outcomes in the form of an increased sense of belonging, the community in socializing, and community initiatives in caring for and managing the built network system. The sustainability of infrastructure development on a community scale will be more guaranteed with the existence of philanthropy in the community.
A Proposal for Implementing Building Information Modeling (BIM) to Manage the Prerequisite Activities in Construction Projects
Authors: Handayani T N , Putri K N R 
Published: August 2021

Abstract
The common practice of construction planning may not formulate the schedule at the appropriate level of detail. Some prerequisite activities such as material supply, plant installation, and document preparation are unorganized. Failure in managing prerequisite activities may increase the risk of delay. Thus, an improvement of the current scheduling practice is substantial which can be performed by adopting technologies. Building Information Modeling (BIM) is an innovative concept that allows us to integrate the schedule and the building element with the ability to control the information systematically. Considering the implementation of BIM is still limited, this paper aims to investigate the potential of BIM to improve the project schedule by detailing the prerequisite activities. The study is started by an extensive literature review to define the status of the current studies and the research gaps. The state of BIM implementation as a tool to improve the project schedule is examined. Lastly, the potential merge between BIM and the utilization of the prerequisites activities is elaborated. The proposal is an initial step to develop a BIM-based system which can automatically assign the prerequisite activities to every building element. It enhances the scheduling practices and minimizes the risk of delay.
Mechanical Behavior of Corroded Steel in Lightweight Concrete: A Review
Authors: Zaki A , Putri O , Yadi S , Rommel E 
Published: August 2021

Abstract
There is an immediate need for reinforced concrete (RC) construction to protect natural resources and environmental sustainability due to a gradual decline in natural resources and a problem in many waste disposal sites used. Reducing natural stones as aggregates in concrete using agriculture waste as aggregate to produce lightweight concrete is an effective way to reduce this problem. Lightweight concrete applications for structural design have long been applied because they significantly benefit design and construction costs. However, limited information about the structural performance, such as the bond strength, the compressive strength can be a barrier to applying lightweight concrete in the construction industry, as inadequate bond strength can result in structural deficiencies in RC structures. Therefore, to launch the use of lightweight concrete as a general material of construction, this research was conducted to review the current information on the mechanical behaviour of corroded lightweight concrete structures, while agricultural solid wastes were used as a lightweight aggregate in the concrete mixture.
Life Cycle Assessment (LCA) on Road Infrastructure Projects: a Systematic Mapping Study
Authors: Lendra  , Wibowo M A , Hatmoko J U D 
Published: August 2021

Abstract
LCA has been utilized over the past two decades to estimate the environmental impacts of pavement in infrastructures. The purpose of this study is to systematically map research on the use of LCA to calculate energy and emissions in road infrastructure projects. The research method is carried out by a literature review, in terms of systematic mapping study of a number of previous scientific publications, in the form of documents that have been published in international and national journals and proceedings, etc., in the last thirty years. The results show that: The topic of LCA is still an interesting area of research, and the trend from year to year shows an increase in the publication of articles in reputable journals. As much as 57.8% research, using the process based calculation method. Only 15.6% of research calculated energy and emissions in the four completed stages of the project life cycle. As much as 37.5% research compared the flexible and rigid pavement as research objects. There is a chance to research the development of the energy optimization model for road infrastructure projects using cradle to cradle system boundary, from initiation to the end of life as a whole project life cycle.
Performance Study of Gendengan Intersection with the Implementation of a One-way System with Contra Flow Bus Lane
Authors: Yulianto B , Setiono  , Marwoto S , Kuswanto  , Sugiyarto  
Published: August 2021

Abstract
The central government plans to provide operational funding for urban public transport in the form of a Buy the Service (BTS) scheme in order to anticipate the degradation of the Batik Solo Trans (BST) public transport performance. One of the efforts to improve BST public transport services is by providing BST public transport a special lane facility on Brigjend Slamet Riyadi road from East to West direction called One-Way System with Contra Flow Bus Lane. This study discusses the design of traffic signal timing settings at Gendengan Intersection with implementation of One-Way System with Contra Flow Bus Lane on Brigjend Slamet Riyadi road. The signalized intersection performance is calculated by using the Indonesian Highway Capacity Manual 1997 method. Several scenarios of traffic signal timing for the signalized intersection are used to find out the best scenario. The results of signalized intersection performance analysis show that with implementation of One-Way System with Contra Flow Bus Lane, the level of service Gendengan intersection has decreased from D to F in the afternoon peak hours for Protected Scenario case, while in the morning and afternoon peak hours remain constant for all scenarios.
The Performance of Demand Responsive Pelican Crossing at Midblock Pedestrian Crossing Facility
Authors: Yulianto B , Putri Salsabila N 
Published: August 2021

Abstract
Pedestrians are travellers who are the most vulnerable to traffic accidents. In general, pedestrian safety in urban areas tends to be neglected. Lack of adequate pedestrian facilities, especially midblock pedestrian crossing facilities, has an impact on pedestrian safety. In order to improve pedestrian safety, therefore the Surakarta city government provides a pedestrian crossing facility, namely Pelican crossing. The existence of a Pelican crossing has an impact on road performance where the traffic and pedestrian flow is regulated by signal timing. The existing Pelican crossing is a type of pedestrian-actuated control logic with fixed-time operation. This study aims to design demand responsive Pelican crossing based on Vehicle Actuated Control Extension Principle (VAC EP) logic, where signal timing is based on real time traffic conditions. The performance of Pelican crossings at midblock pedestrian crossing facility is analysed by using a calibrated and validated VISSIM simulation model. The performance of the proposed Pelican crossing (VAC EP) is compared to the existing Pelican crossing. The simulation analysis results show that the proposed Pelican crossing (VAC EP) performance is better than the existing Pelican crossing, in terms of average pedestrian delay.
Potential Tsunami Hazard on the Coast of the Indonesia’s New Capital Candidate
Authors: Karima Shofia , Kongko Widjo , Khoirunnisa Hanah , Hendriyono Wahyu , Wibowo Mardi 
Published: August 2021

AbstractOn the 26th of August 2019, the Indonesian government announced the location of the new nation’s capital city. The plan to move the capital city raises various pros, cons, and several challenges, including those from natural disaster aspects. East Kalimantan’s coastal area faces the Makassar Strait waters which have the potential for tsunamis, either originating from landslides or from the megathrust. The megathrust earthquake that has the potential to cause a tsunami in the area is the megathrust of North Sulawesi. In 1997, an earthquake measuring 7.9 Mw originating from the megathrust caused a catastrophic tsunami. According to Peta Gempa (Pusgen, 2017), the North Sulawesi Megathrust has the worst potential for an earthquake of magnitude 8.5. In this research, the tsunami wave height and the estimated time of arrival will be simulated using the TUNAMI numerical model. In addition, analyses from the simulation results are also made for coastal areas with high activity and large population (Palu, Toli-toli, Donggala, Mamuju, Samarinda, Berau, Kutai, and Bontang). The simulation results of this model show that the maximum height of the tsunami waves on the coast of East Kalimantan is 0.83 meters and the arrival time is around 1.6 to 2 hours.
Analysis of Floodwater Level and Periodic Maintenance of Celeng River, Bantul
Authors: Ammara N D , Maryono A , Sulaiman M 
Published: August 2021

Abstract
Flooding in the Celeng River usually occurs after high-intensity rains. The Celeng River cannot accommodate any water from the hills around Imogiri and Dlingo. Channel modeling was carried out using HEC-RAS 5.0.7 simulations to determine the river capacity and floodwater level as a control design for periodic maintenance planning. The results of HEC-RAS 5.0.7 modeling in the existing conditions show that there were floods at several points. The usual effort is to make retaining walls. The river morphology, which is changed by the construction of the retaining wall, will accelerate the water rate so that the volume of water in the downstream part is high and will only move the flood to another place. This destructive to the environment, so flood mitigation using bio-engineering methods is proposed to answer the problem.