bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microfacies analysis and petrographic study of the Mishrif Formation, in selected wells from southeastern of Iraq
Authors: Saleh Dr. Afrah H. 
Published: May 2021

Mishrif carbonates formation, is a major reservoir in southeast of Iraq and is one of the principle carbonate reservoir in central and southern Iraq, which is of Late Cenomanian to Early Turronian. A petrographic and depositional Environment study has been carried out by examining available thin sections in the Ministry of Oil for wells (No-1, No-2 (Noor field), Am-1(Amara field) and Hf-1 (Halfaya field)).
The main skeletal grains of the Mishrif formation include coral, Rudist, large and small benthonic Foraminifera & planktonic Foraminifera (Planktonic Foraminifera are common in the lower part of the Mishrif Formation), ostracods, echinoderms, and molluscs. The Rudist were found in small to large fragments; and as a complete fossil covering the whole thin section. The Non-skeletal grains included peloids, and micrite.
The most important diagenetic processes affecting on the Mishrif Formation are dolomitization, dissolution, cementation, micritization, recrystallization and Stylolite.
Mishrif succession comprises six paleoenvironments which are deep marine, shallow open marine, rudist biostrome, shoal, back shoal, and lagoon.
The Use of Bitumen in the Stabilization of Lead Contaminated Iraqi Soil
Authors: Mutter Dr. Ghazi Maleh 
Published: May 2021

Iraq is one of the biggest countries in oil production and its processes. Bitumen is a by-product material that remains after the process of crude oil. This study is designed to investigate the role of bitumen in the stabilization of lead contaminated Iraqi soil; as measured by a newly developed “mini” Jet Device and the dispersion ratio method (DR,%).
The results revealed that both bitumen amount and its method of mixing with soil, as a direct or as emulsion mixing, can significantly improve the stability of lead contaminated soil. Hence, only 3% bitumen as emulsion mixing was required to get the optimum soil stabilization, compared with 9% in direct mixing. A 3% bitumen emulsion has reduced both the scouring depth (SD, from 24.5 to1.6 mm; R= -0.90) and the erodibility coefficient (Kd, from 1.09 to 0.14; R= -0.86) as a result of improving soil engineering properties related to soil stabilization. However, the 3% of bitumen emulsion has also improved the soil chemical properties that have an important role in soil aggregation and lead mobility; such as pH, EC and SAR. Therefore, 3% of bitumen emulsion has successfully decreased both the dispersion ratio (DR, % from 7.03 to 4.48; R= -0.90) and the lead solubility (Pb from 48.8 to 4.9ppm; R= -0.96) in the solutions of lead contaminated soil.
Avaliação e remodelagem de um jogo sério para prevenção do abuso sexual infantil
Authors: Fava Alexandre Mendonça , Berkenbrock Carla Diacui Medeiros , Vahldick Adilson 
Published: May 2021

Para o ano de 2018, o Disque 100, canal de denúncia oficial do Ministério da Mulher, da Família e dos Direitos Humanos, totalizou 17.093 denúncias de violência sexual contra crianças e adolescentes. Em resposta a violência infantil, surgiram algumas estratégias baseadas em jogos para a prevenção do abuso sexual contra os menores. Entre os jogos, destaca-se um jogo pela sua abordagem colaborativa no combate à violência sexual infantil no Brasil. O jogo foi avaliado pela presente pesquisa com o intuito de assegurar sua qualidade, tanto em níveis educacionais, quanto em níveis ergonômicos. A análise revelou divergências entre o jogo e recomendações presentes na literatura acerca da criação e modelagem de jogos. Tais divergências serviram como base para a criação de uma nova versão do jogo. Ao final, ambas as versões foram comparadas por meio da metodologia avaliativa MEEGA. O processo avaliativo realizado constatou uma melhor motivação e experiência dos usuários para nova versão do jogo. Como resultado, essa pesquisa traz um jogo potencialmente promissor para a prevenção da violência sexual infantil.
Deformation, Magmatism, and Sulfide Mineralization in the Archean Golden Mile Fault Zone, Kalgoorlie Gold Camp, Western Australia
Authors: McDivitt Jordan A. , Hagemann Steffen G. , Thébaud Nicolas , Martin Laure A.J. , Rankenburg Kai 
Published: May 2021

AbstractThe Golden Mile fault zone is a key controlling structure to the estimated 75 Moz gold endowment of the Kalgoorlie gold camp in the Yilgarn craton of Western Australia. The earliest structures in the fault are F1 folds that developed during D1 recumbent-fold and thrust deformation (&lt;2685 ± 4 Ma). These F1 folds are overprinted by a pervasive NW- to NNW-striking S2 cleavage related to sinistral shearing beginning with 2680 ± 3 Ma D2a sinistral strike-slip and culminating with ca. 2660 Ma D2c sinistral-reverse movement. The majority of deformation in the fault zone correlates to ca. 2675 Ma D2b deformation, which is characterized by sinistral-normal kinematic indicators. Late, ca. 2650–2640 Ma D3 dextral-reverse kinematic indicators overprint the earlier D2 structures. Pyrrhotite-chalcopyrite-pyrite-sphalerite-galena assemblages were emplaced throughout the D2 event within NE-trending D2a tensile fractures, NW- to NNW-striking D2b normal faults and associated breccias, and NW- to NNW-striking D2c low-angle veins, with the latter D2b and D2c structures correlating to the Fimiston and Oroya mineralization types, respectively. All D2a-, D2b-, and D2c-related sulfides in the Golden Mile fault zone show similarly restricted δ34S (~1.0–4.5‰) and elevated Δ33S (~2.0–3.0‰) values that reflect strong local sulfur contribution from shales of the Lower Black Flag Group and host-rock buffering of hydrothermal fluids related to the Fimiston and Oroya mineralization events. This host-rock buffering decreased fluid fO2, favoring the development of pyrrhotite-pyrite stable sulfide assemblages and causing respective decreases and increases in fluid Au-Te and Pb-Bi-Sb concentrations. At the camp scale, the Golden Mile fault zone exerted a primary control on the distribution of porphyry dikes and gold deposits; however, magma and hydrothermal fluid circulation was favored in adjacent, higher-order structural sites due to the fault zone’s incompetent rheology and tendency for ductile deformation and diffuse fluid flow. Other Archean examples such as Au deposits of the Larder Lake-Cadillac deformation zone in the Superior craton illustrate that this type of diffuse fluid flow in large-scale crustal fault zones can result in disseminated economic mineralization. However, this study highlights that host-rock effects on fluid chemistry in large-scale crustal fault zones exercises a strong control on a fluid’s propensity to form ore. The results of this study emphasize that both the rheology and chemistry of rocks within and adjacent to large-scale deformation zones act as important controls on the formation of gold ore in Archean terranes.
Image quality assessments according to the angle of tilt of a flex tilt coil supporting device: An ACR phantom study
Authors: Lee Ho Beom , Jang Ji Sung , Lee Ki Baek , Kim Sung Min 
Published: May 2021

AbstractIn this study, we assessed how image quality depends on the angle of tilt of a flex tilt coil supporting device during an MRI examination. All measurements were performed with an American College of Radiology (ACR) MRI phantom using a flex tilt coil supporting device. All images were analyzed using an automatic assessment method following the ACR MRI accreditation guidance. Image quality was compared between acquisitions grouped according to the angle of tilt of the coil supporting device: group A (Flat mode), group B (10˚), and group C (18˚). All measured image qualities were within the ACR recommended criteria, regardless of the angle of tilt of the flex tilt coil supporting device. However, statistically significant differences between the three groups were found for slice thickness, position accuracy, image intensity uniformity, and SNR (P < 0.05, ANOVA). The flex tilt coil supporting device can provide sufficient image quality, passing the criteria of the ACR MRI guideline, despite differences in slice thickness, slice position accuracy, image intensity uniformity, and SNR according to the angle of tilt.
Intrinsic detector sensitivity analysis as a tool to characterize ArcCHECK and EPID sensitivity to variations in delivery for lung SBRT VMAT plans
Authors: Alharthi Thahabah , Vial Phil , Holloway Lois , Thwaites David 
Published: May 2021

AbstractPurposeTo investigate intrinsic sensitivity of an electronic portal imaging device (EPID) and the ArcCHECK detector and to use this in assessing their performance in detecting delivery variations for lung SBRT VMAT. The effect of detector spatial resolution and dose matrix interpolation on the gamma pass rate was also considered.Materials and methodsFifteen patients’ lung SBRT VMAT plans were used. Delivery variations (errors) were introduced by modifying collimator angles, multi‐leaf collimator (MLC) field sizes and MLC field shifts by ±5, ±2, and ±1 degrees or mm (investigating 103 plans in total). EPID and ArcCHECK measured signals with introduced variations were compared to measured signals without variations (baseline), using OmniPro‐I'mRT software and gamma criteria of 3%/3 mm, 2%/2 mm, 2%/1 mm, and 1%/1 mm, to test each system's basic performance. The measurement sampling resolution for each was also changed to 1 mm and results compared to those with the default detector system resolution.ResultsIntrinsic detector sensitivity analysis, that is, comparing measurement to baseline measurement, rather than measurement to plan, demonstrated the intrinsic constraints of each detector and indicated the limiting performance that users might expect. Changes in the gamma pass rates for ArcCHECK, for a given introduced error, were affected only by dose difference (DD %) criteria. However, the EPID showed only slight changes when changing DD%, but greater effects when changing distance‐to‐agreement criteria. This is pertinent for lung SBRT where the minimum dose to the target will drop dramatically with geometric errors. Detector resolution and dose matrix interpolation have an impact on the gamma results for these SBRT plans and can lead to false positives or negatives in error detection if not understood.ConclusionThe intrinsic sensitivity approach may help in the selection of more meaningful gamma criteria and the choice of optimal QA device for site‐specific dose verification.
Selective vulnerability to atrophy in sporadic Creutzfeldt‐Jakob disease
Authors: Younes Kyan , Rojas Julio C. , Wolf Amy , Sheng‐Yang Goh M. , Paoletti Matteo , Toller Gianina , Caverzasi Eduardo , Luisa Mandelli Maria , Illán‐Gala Ignacio , Kramer Joel H. , Cobigo Yann , Miller Bruce L. , Rosen Howard J. , Geschwind Michael D. 
Published: May 2021

AbstractObjectiveIdentification of brain regions susceptible to quantifiable atrophy in sporadic Creutzfeldt‐Jakob disease (sCJD) should allow for improved understanding of disease pathophysiology and development of structural biomarkers that might be useful in future treatment trials. Although brain atrophy is not usually present by visual assessment of MRIs in sCJD, we assessed whether using voxel‐based morphometry (VBM) can detect group‐wise brain atrophy in sCJD.Methods3T brain MRI data were analyzed with VBM in 22 sCJD participants and 26 age‐matched controls. Analyses included relationships of regional brain volumes with major clinical variables and dichotomization of the cohort according to expected disease duration based on prion molecular classification (i.e., short‐duration/Fast‐progressors (MM1, MV1, and VV2) vs. long‐duration/Slow‐progressors (MV2, VV1, and MM2)). Structural equation modeling (SEM) was used to assess network‐level interactions of atrophy between specific brain regions.ResultssCJD showed selective atrophy in cortical and subcortical regions overlapping with all but one region of the default mode network (DMN) and the insulae, thalami, and right occipital lobe. SEM showed that the effective connectivity model fit in sCJD but not controls. The presence of visual hallucinations correlated with right fusiform, bilateral thalami, and medial orbitofrontal atrophy. Interestingly, brain atrophy was present in both Fast‐ and Slow‐progressors. Worse cognition was associated with bilateral mesial frontal, insular, temporal pole, thalamus, and cerebellum atrophy.InterpretationBrain atrophy in sCJD preferentially affects specific cortical and subcortical regions, with an effective connectivity model showing strength and directionality between regions. Brain atrophy is present in Fast‐ and Slow‐progressors, correlates with clinical findings, and is a potential biomarker in sCJD.
Swallowing‐related neural oscillation: an intracranial EEG study
Authors: Hashimoto Hiroaki , Takahashi Kazutaka , Kameda Seiji , Yoshida Fumiaki , Maezawa Hitoshi , Oshino Satoru , Tani Naoki , Khoo Hui Ming , Yanagisawa Takufumi , Yoshimine Toshiki , Kishima Haruhiko , Hirata Masayuki 
Published: May 2021

AbstractObjectiveSwallowing is a unique movement due to the indispensable orchestration of voluntary and involuntary movements. The transition from voluntary to involuntary swallowing is executed within milliseconds. We hypothesized that the underlying neural mechanism of swallowing would be revealed by high‐frequency cortical activities.MethodsEight epileptic participants fitted with intracranial electrodes over the orofacial cortex were asked to swallow a water bolus and cortical oscillatory changes, including the high γ band (75–150 Hz) and β band (13–30 Hz), were investigated at the time of mouth opening, water injection, and swallowing.ResultsIncreases in high γ power associated with mouth opening were observed in the ventrolateral prefrontal cortex (VLPFC) with water injection in the lateral central sulcus and with swallowing in the region along the Sylvian fissure. Mouth opening induced a decrease in β power, which continued until the completion of swallowing. The high γ burst of activity was focal and specific to swallowing; however, the β activities were extensive and not specific to swallowing. In the interim between voluntary and involuntary swallowing, swallowing‐related high γ power achieved its peak, and subsequently, the power decreased.InterpretationWe demonstrated three distinct activities related to mouth opening, water injection, and swallowing induced at different timings using high γ activities. The peak of high γ power related to swallowing suggests that during voluntary swallowing phases, the cortex is the main driving force for swallowing as opposed to the brain stem.
Steroids Enable Mesenchymal Stromal Cells to Promote CD8+ T Cell Proliferation Via VEGF‐C
Authors: Gan Yurun , Zhang Tao , Chen Xiaodong , Cao Wei , Lin Liangyu , Du Liming , Wang Yu , Zhou Fei , He Xuefeng , He Yulong , Gan Jianhe , Sheng Huiming , Sorokin Lydia , Shi Yufang , Wang Ying 
Published: May 2021

AbstractMesenchymal stromal cells (MSCs) function as a formidable regulator of inflammation and tissue homeostasis and expanded MSCs are shown to be effective in treating various inflammatory diseases. Their therapeutic effects require the existence of certain inflammatory cytokines. However, in the absence of sufficient proinflammatory stimuli or in the presence of anti‐inflammatory medications, MSCs are animated to promote immune responses and unable to alleviate inflammatory disorders. In this study, it is demonstrated that steroid co‐administration interferes the efficacy of MSCs in treating acute graft‐versus‐host disease (aGvHD). Molecular analysis reveals that vascular endothelial growth factor C (VEGF‐C) is highly induced in MSCs by steroids and TNFα and VEGF‐C in turn promotes CD8+ T cell response. This immune promoting effect is abolished by blockade or specific genetic ablation of VEGFR3 in CD8+ T cells. Additionally, administration of VEGF‐C alone exacerbates aGvHD progression through eliciting more vigorous CD8+ T cell activation and proliferation. Further studies demonstrate that VEGF‐C augments the PI3K/AKT signaling process and the expression of downstream genes, such as Cyclin D1. Thus, the data demonstrate that steroids can reverse the immunosuppressive effect of MSCs via promoting VEGF‐C‐augmented CD8+ T cell response and provide novel information for designing efficacious MSC‐based therapies.
Functional Features and Current Applications of the RNA‐Targeting Type VI CRISPR‐Cas Systems
Authors: Perčulija Vanja , Lin Jinying , Zhang Bo , Ouyang Songying 
Published: May 2021

AbstractCRISPR‐Cas systems are a form of prokaryotic adaptive immunity that employs RNA‐guided endonucleases (Cas effectors) to cleave foreign genetic elements. Due to their simplicity, targeting programmability, and efficiency, single‐effector CRISPR‐Cas systems have great potential for application in research, biotechnology, and therapeutics. While DNA‐targeting Cas effectors such as Cas9 and Cas12a have become indispensable tools for genome editing in the past decade, the more recent discovery of RNA‐targeting CRISPR‐Cas systems has opened the door for implementation of CRISPR‐Cas technology in RNA manipulation. With an increasing number of studies reporting their application in transcriptome engineering, viral interference, nucleic acid detection, and RNA imaging, type VI CRISPR‐Cas systems and the associated Cas13 effectors particularly hold promise as RNA‐targeting or RNA‐binding tools. However, even though previous structural and biochemical characterization provided a firm basis for leveraging type VI CRISPR‐Cas systems into such tools, the lack of comprehension of certain mechanisms underlying their functions hinders more sophisticated and conventional use. This review will summarize current knowledge on structural and mechanistic properties of type VI CRISPR‐Cas systems, give an overview on the reported applications, and discuss functional features that need further investigation in order to improve performance of Cas13‐based tools.
The Role of Dimensionality on the Optoelectronic Properties of Oxide and Halide Perovskites, and their Halide Derivatives
Authors: Hoye Robert L. Z. , Hidalgo Juanita , Jagt Robert A. , Correa‐Baena Juan‐Pablo , Fix Thomas , MacManus‐Driscoll Judith L. 
Published: May 2021

AbstractHalide perovskite semiconductors have risen to prominence in photovoltaics and light‐emitting diodes (LEDs), but traditional oxide perovskites, which overcome the stability limitations of their halide counterparts, have also recently witnessed a rise in potential as solar absorbers. One of the many important factors underpinning these developments is an understanding of the role of dimensionality on the optoelectronic properties and, consequently, on the performance of the materials in photovoltaics and LEDs. This review article examines the role of structural and electronic dimensionality, as well as form factor, in oxide and halide perovskites, and in lead‐free alternatives to halide perovskites. Insights into how dimensionality influences the band gap, stability, charge‐carrier transport, recombination processes and defect tolerance of the materials, and the impact these parameters have on device performance are brought forward. Particular emphasis is placed on carrier/exciton‐phonon coupling, which plays a significant role in the materials considered, owing to their soft lattices and composition of heavy elements, and becomes more prominent as dimensionality is reduced. It is finished with a discussion of the implications on the classes of materials future efforts should focus on, as well as the key questions that need to be addressed.
Triplet‐Charge Annihilation in a Small Molecule Donor: Acceptor Blend as a Major Loss Mechanism in Organic Photovoltaics
Authors: Marin‐Beloqui Jose M. , Toolan Daniel T. W. , Panjwani Naitik A. , Limbu Saurav , Kim Ji‐Seon , Clarke Tracey M. 
Published: May 2021

AbstractOrganic photovoltaics (OPV) are close to reaching a landmark 20% device efficiency. One of the proposed reasons that OPVs have yet to attain this milestone is their propensity toward triplet formation. Herein, a small molecule donor, DRCN5T, is studied using a variety of morphology and spectroscopy techniques, and blended with both fullerene and non‐fullerene acceptors. Specifically, grazing incidence wide‐angle X‐ray scattering and transient absorption, Raman, and electron paramagnetic resonance spectroscopies are focused on. It is shown that despite DRCN5T's ability to achieve OPV efficiencies of over 10%, it generates an unusually high population of triplets. These triplets are primarily formed in amorphous regions via back recombination from a charge transfer state, and also undergo triplet‐charge annihilation. As such, triplets have a dual role in DRCN5T device efficiency suppression: they both hinder free charge carrier formation and annihilate those free charges that do form. Using microsecond transient absorption spectroscopy under oxygen conditions, this triplet‐charge annihilation (TCA) is directly observed as a general phenomenon in a variety of DRCN5T: fullerene and non‐fullerene blends. Since TCA is usually inferred rather than directly observed, it is demonstrated that this technique is a reliable method to establish the presence of TCA.
Universal correlation for gas hydrates suppression temperature of inhibited systems: IV. Water activity
Authors: Sa Jeong‐Hoon , Sum Amadeu K. 
Published: May 2021

AbstractIn Parts I, II, and III, the Hu‐Lee‐Sum (HLS) correlation was demonstrated to be a robust method for determining the hydrate suppression temperatures for structure I and II hydrates containing inorganic salts and organic inhibitors. Here, Part IV introduces two different approaches to estimate the water activity for systems containing inhibitors: ice melting point and activity coefficient models. The ice melting point is translated into the water activity changes, which can then be directly used for the hydrate suppression temperatures. The great benefit of this method is its applicability to any inhibited systems with unknown compositions of inhibitors. The activity coefficient model is based on widely available models. These methods for determining the water activity allow for a simple yet reliable prediction of hydrate suppression temperatures for inhibited systems, which advocate for their use in place of the more traditional methods known to be less reliable and less accurate.
PtZn intermetallic nanoalloy encapsulated in silicalite‐1 for propane dehydrogenation
Authors: Zhang Bofeng , Li Guozhu , Zhai Ziwei , Chen Dali , Tian Yajie , Yang Ruoou , Wang Li , Zhang Xiangwen , Liu Guozhu 
Published: May 2021

AbstractPropane dehydrogenation (PDH) is one of the most effective methods to produce propylene. But the industrial Pt‐based catalysts often suffer from short‐term stability under the high temperature reaction environment (500–700°C) via sintering and coke deposition. Herein, stable PDH reaction in high propylene yield has been achieved by the confinement of Pt–Zn intermetallic alloys (IMAs) in the channels of silicalite‐1. Single‐site Zn in the MFI framework was found to play a key role on assisting and stabilizing the PtZn IMAs for efficient PDH. By the cooperative action of the spatial confined PtZn IMAs and the lattice confined framework Zn, high propylene selectivity (>99%) without obvious deactivation was realized on the as‐developed catalyst (PtZn@S‐1) under 600°C even after 90 h. The low deactivation constant (0.003 h−1) was 6 times lower than that of the industrial PtSn catalyst.