bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seaweed farming pressure affects seagrass and benthic macroalgae dynamics in Chwaka Bay (Zanzibar, Tanzania)
Authors: Moreira-Saporiti Agustín , Hoeijmakers Dieuwke , Msuya Flower E. , Reuter Hauke , Teichberg Mirta 
Published: January 2021

AbstractFarming of Eucheuma denticulatum is a major activity in Zanzibar affecting seagrass ecosystems primarily through shading and trampling. The aim of this study was to test the impacts of shading and trampling during seaweed farming on seagrass meadows composed by Halophila stipulacea and Thalassia hemprichii and their associated benthic macroalgae. Areas covered by these species were selected for the building of seaweed farms in three treatments: seaweed farm plots (with shading and trampling effects), trampling plots (with trampling effects only), and control plots (with no shading or trampling effects). Reduction of light within the plots was recorded over 9 weeks. Percentage cover of seagrasses and macroalgae and shoot density of seagrasses were measured over 12 weeks to assess the impact of shading and trampling by seaweed farming activities. Light was significantly reduced in the seaweed farm plots by 75 to 90% by the end of a seaweed growth cycle. H. stipulacea, despite its capacity for rapid growth, was significantly affected by the combination of shading and trampling under the seaweed farm treatment, while the climax seagrass species T. hemprichii was unaffected. Due to the decline in H. stipulacea, benthic macroalgae cover increased in the seaweed farm treatment, suggesting a change in seagrass community dynamics. In contrast, trampling had a negative effect on the benthic macroalgae as an isolated disturbance, which suggests that seagrasses are more resistant to trampling than macroalgae and would likely dominate the benthic macrophyte community under these conditions.
Involvement of medical students in a surgery congress: impact on learning motivation, decision-making for a career in surgery, and educational curriculum
Authors: Alkatout Ibrahim , Günther Veronika , Brügge Sandra , Ackermann Johannes , Krüger Magret , Bauerschlag Dirk , Maass Nicolai , Lippross Sebastian , Cascorbi Ingolf , Egberts Jan-Hendrik , Becker Thomas , Osmonov Daniar , Jünemann Klaus-Peter , Wedel Thilo 
Published: January 2021

SummaryDuring the preclinical period of medical school, the clinical relevance of theoretical knowledge is given little attention. Medical students of the second year were invited to participate in an interdisciplinary congress for robot-assisted and digital surgery. The students had to evaluate the impact of the congress on their learning motivation, decision-making for a career in surgery, and relevance for their educational curriculum. Participation in the congress increased their learning motivation for preclinical subjects, and significantly increased their interest in a surgical career. Most students considered active involvement in medical congresses a valuable supplement to the medical curriculum. Congress participation during the preclinical period was ranked positively by medical students. Greater learning motivation and enthusiasm for the pilot teaching project as well as for surgical disciplines were registered. Thus, early involvement of medical students in scientific congresses should be an integral part of their educational curriculum.
Multi-GPU approach to global induction of classification trees for large-scale data mining
Authors: Jurczuk Krzysztof , Czajkowski Marcin , Kretowski Marek 
Published: January 2021

AbstractThis paper concerns the evolutionary induction of decision trees (DT) for large-scale data. Such a global approach is one of the alternatives to the top-down inducers. It searches for the tree structure and tests simultaneously and thus gives improvements in the prediction and size of resulting classifiers in many situations. However, it is the population-based and iterative approach that can be too computationally demanding to apply for big data mining directly. The paper demonstrates that this barrier can be overcome by smart distributed/parallel processing. Moreover, we ask the question whether the global approach can truly compete with the greedy systems for large-scale data. For this purpose, we propose a novel multi-GPU approach. It incorporates the knowledge of global DT induction and evolutionary algorithm parallelization together with efficient utilization of memory and computing GPU’s resources. The searches for the tree structure and tests are performed simultaneously on a CPU, while the fitness calculations are delegated to GPUs. Data-parallel decomposition strategy and CUDA framework are applied. Experimental validation is performed on both artificial and real-life datasets. In both cases, the obtained acceleration is very satisfactory. The solution is able to process even billions of instances in a few hours on a single workstation equipped with 4 GPUs. The impact of data characteristics (size and dimension) on convergence and speedup of the evolutionary search is also shown. When the number of GPUs grows, nearly linear scalability is observed what suggests that data size boundaries for evolutionary DT mining are fading.
Concordance of the 21-gene assay between core needle biopsy and resection specimens in early breast cancer patients
Authors: Qi Peng , Yang Yu , Bai Qian-ming , Xue Tian , Ren Min , Yao Qian-lan , Yang Wen-tao , Zhou Xiao-yan 
Published: January 2021

Abstract
Background
Adjuvant therapy decisions may be partly based on the results of a multigene quantitative reverse transcription-polymerase chain reaction (RT-PCR)-based assay: the 21-gene recurrence score (RS) test of resection specimens. When necessary, core needle biopsy (CNB) may be considered as a surrogate. Here, we evaluated the concordance in gene expression according to results from RT-PCR-based RS testing between paired CNBs and resection specimens.

Methods
CNBs and resection specimens from 50 breast cancer (BC) patients were tested to calculate RSs. First, we examined the concordance of the ER, PR and HER-2 status of tissue samples indicated by immunohistochemical (IHC) and RT-PCR analyses. Then, we compared the IHC findings of ER, PR, HER-2 and Ki-67 staining across paired samples. Ultimately, the RS and single-gene results for ER, PR, HER-2 and Ki-67 were explored between paired samples.

Results
The concordance between IHC and RT-PCR was 100%, 80.0% and 100% for ER, PR and HER-2, respectively, in both resection specimens and CNBs. The concordance for IHC ER, PR, HER-2 and Ki-67 status was 100%, 94.0%, 52.0% and 82.0%, respectively, between paired samples. RS results from paired samples showed a strong correlation. The overall concordance in RS group classification between samples was 74%, 72% and 78% based on traditional cutoffs, TAILORx cutoffs and ASCO guidelines, respectively. ER, PR, HER-2 and Ki-67 were modestly- to- strongly correlated between paired samples according to the RT-PCR results.

Conclusion
A modest- to- strong correlation of ER, PR, HER-2 and Ki-67 gene expression and RS between CNBs and resection specimens was observed in the present study. The 21-gene RS test could be reliably performed on CNBs. ER, PR and HER-2 status showed remarkable concordance between the IHC and RT-PCR analyses. The concordance between paired samples was high for the IHC ER, PR and Ki-67 results and low for HER-2.
TuLeD (Tupían lexical database): introducing a database of a South American language family
Authors: Gerardi Fabrício Ferraz , Reichert Stanislav , Aragon Carolina Coelho 
Published: January 2021

AbstractThe last two decades witnessed a rapid growth of publicly accessible online language resources. This has allowed for valuable data on lesser known languages to become available. Such resources provide linguists with opportunities for advancing their research. Yet despite the proliferation of lexical and morphological databases, the ca. 456 languages spoken in South America are poorly represented, particularly the Tupían family, which is the largest on the continent. This paper therefore introduces and discusses TuLeD, a lexical database exclusively devoted to a South American language family. It provides a comprehensive list of lexical items presented in a unified transcription for all languages with cognacy assignment and relevant (cultural or linguistic) notes. One of the main goals of TuLeD is to become a full-fledged database and a benchmark for linguistic studies on South American languages in general and the Tupían family in particular.
“We Became Rich and We Lost Everything”: Ethnobotany of Remote Mountain Villages of Abruzzo and Molise, Central Italy
Authors: Mattalia Giulia , Sõukand Renata , Corvo Paolo , Pieroni Andrea 
Published: January 2021

AbstractProfound socioeconomic changes affected mountains of Central Italy during the last century and many traditional agro-pastoral activities were abandoned. A few ethnobotanical studies in this area have specifically documented local wild plants used decades ago, but without analyzing in-depth how and why Traditional Ecological Knowledge (TEK) has eroded or changed over time. In this study, we 1) document ethnobotanical uses of four high-altitude remote villages of Central Italy, 2) discuss how these uses have changed over time, comparing them with fieldwork that was conducted 40 years earlier; and 3) assess how plant uses have changed across space, particularly whether the remoteness of villages or the occurrence of Sacred Natural Sites (SNS) have affected TEK linked to wild plants. Sixty semi-structured interviews revealed the use of 83 taxa belonging to 35 families. We did not find any relationship between SNS and the richness of TEK, as these SNS were not inhabited by monastic communities that could have shared their scholarly knowledge. There was not a relationship between remoteness and richness of TEK. The common statement emerging from the field, “We became rich and lost everything”, revealed how socio-economic changes resulted in the rapid abandonment of traditional practices, while the ubiquity of pharmacies may have contributed to the erosion of ethnomedicinal knowledge.
Obtaining spores for the production of Saccharina latissima: seasonal limitations in nature, and induction of sporogenesis in darkness
Authors: Boderskov Teis , Rasmussen Michael Bo , Bruhn Annette 
Published: January 2021

AbstractWhen cultivating the kelp Saccharina latissima, knowledge on the availability of seeding material for the production is essential. Applying a spore seeding approach requires spores from the reproductive organs of the fertile sporophytes (sori). As sori are generally not present during the time of seeding in late summer, the production of spores (sporogenesis) can be artificially induced by removing the meristematic part of the sporophyte and keeping the sporophyte under short day, temperate, and nutrient-replete conditions. Only limited information is available on the effect of light intensities including darkness on the sporogenesis of S. latissima. This study examined the natural pattern of sporogenesis in S. latissima from Middelfart, Denmark, and the effect of four different light regimes (0, 20, 60, or 120 μmol photons m−2 s−1) on the artificial induction of sporogenesis in S. latissima. Natural reproductivity and availability of spores in Denmark peaked in early winter, with 86% of the population being reproductive in November. Reproductive material was available from October until late spring, but with a variable spore release from 11 × 103 to 1.2 × 106 spores cm−2 sori. The artificial induction of sporogenesis was optimal in darkness with > 90% of sporophytes developing sori after 49 days, with an average spore release density of 1.15 ± 0.38 × 106 spores cm−2 sori. The results confirmed that S. latissima in Denmark follows the general pattern of reproduction of S. latissima in North Atlantic regions and demonstrated for the first time that sporogenesis in S. latissima can be efficiently induced in darkness.
The one, the true, the good… or not: Badiou, Agamben, and atheistic transcendentality
Authors: Leung King-Ho 
Published: January 2021

AbstractThis article offers a reading of the “transcendental” character of Alain Badiou’s and Giorgio Agamben’s ontologies. While neither Badiou nor Agamben are “transcendental” philosophers in the Kantian sense, this article argues that their respective projects of ontology both recover aspects of the “classical” conception of the transcendentals. Not unlike how pre-modern philosophers conceived of oneness, truth and goodness as transcendental properties of all things, both Badiou’s and Agamben’s ontologies present various structures which can be universally predicated of all being. However, as opposed to the essentialist or even theological tendencies of traditional metaphysics, Badiou’s and Agamben’s ontologies are committedly “inessential” and atheistic at their very core. By replacing the divine names of the one, the true and the good in traditional metaphysics with a new yet quasi-classical transcendental notion of “the void” as a universal predicate of all beings, Badiou’s and Agamben’s works may be regarded as projects that go beyond both the pre-Kantian “theological” and the post-Kantian “subjective” conceptions of transcendental philosophy, thereby marking a new development in the history of western metaphysics.
Protein recovery as a resource from waste specifically via membrane technology—from waste to wonder
Authors: Shahid Kanwal , Srivastava Varsha , Sillanpää Mika 
Published: January 2021

AbstractEconomic growth and the rapid increase in the world population has led to a greater need for natural resources, which in turn, has put pressure on said resources along with the environment. Water, food, and energy, among other resources, pose a huge challenge. Numerous essential resources, including organic substances and valuable nutrients, can be found in wastewater, and these could be recovered with efficient technologies. Protein recovery from waste streams can provide an alternative resource that could be utilized as animal feed. Membrane separation, adsorption, and microbe-assisted protein recovery have been proposed as technologies that could be used for the aforementioned protein recovery. This present study focuses on the applicability of different technologies for protein recovery from different wastewaters. Membrane technology has been proven to be efficient for the effective concentration of proteins from waste sources. The main emphasis of the present short communication is to explore the possible strategies that could be utilized to recover or restore proteins from different wastewater sources. The presented study emphasizes the applicability of the recovery of proteins from various waste sources using membranes and the combination of the membrane process. Future research should focus on novel technologies that can help in the efficient extraction of these high-value compounds from wastes. Lastly, this short communication will evaluate the possibility of integrating membrane technology. This study will discuss the important proteins present in different industrial waste streams, such as those of potatoes, poultry, dairy, seafood and alfalfa, and the possible state of the art technologies for the recovery of these valuable proteins from the wastewater.
Graphical abstract
Two pleosporalean root-colonizing fungi, Fuscosphaeria hungarica gen. et sp. nov. and Delitschia chaetomioides, from a semiarid grassland in Hungary
Authors: Pintye Alexandra , Knapp Dániel G. 
Published: January 2021

AbstractIn this study, we investigated two unidentified lineages of root-colonizing fungi belonging to the order Pleosporales (Dothideomycetes), which were isolated from Festuca vaginata (Poaceae), a dominant grass species in the semiarid sandy grasslands of Hungary. For molecular phylogenetic studies, seven loci (internal transcribed spacer, partial large subunit and small subunit region of nrRNA, partial transcription elongation factor 1-α, RNA polymerase II largest subunit, RNA polymerase II second largest subunit, and ß-tubulin genes) were amplified and sequenced. Based on morphology and multilocus phylogenetic analyses, we found that one lineage belonged to Delitschia chaetomioides P. Karst. (Delitschiaceae), and the isolates of the other lineage represented a novel monotypic genus in the family Trematosphaeriaceae (suborder Massarineae). For this lineage, we proposed a new genus, Fuscosphaeria, represented by a single species, F. hungarica. In both lineages, only immature and degenerated sporocarps could be induced. These were sterile, black, globose, or depressed globose structures with numerous mycelioid appendages submerged in culture media or on the surface of autoclaved plant materials. Both species are first reported here as root-colonizing fungi.
The Challenge of Mysticism: a Primer from a Christian Perspective
Authors: Spencer Daniel 
Published: January 2021

AbstractIn this article, I discuss the relevance of the study of mysticism for Christian analytic theologians and philosophers of religion. I begin with a brief consideration of some reasons Christian academics might be reluctant to enter this field, and indicate that, somewhat surprisingly, the study of mysticism is something but seldom addressed in Christian analytic circles. With this background in place, I proceed to the primary two sections of the article. Section I deals with demarcating mysticism: for the purposes of this article alone, an experience will count as mystical if and only if it is strongly unitive, transcends everyday consciousness, and (allegedly) conveys epistemic certainty as to the veracity of the insights acquired. These three criteria are discussed in some depth. Section II turns to the challenge mysticism in this sense might present to the Christian philosopher or theologian. I argue that the phenomenon of mysticism might be seen plausibly to imply one of two conclusions, both of which appear to be unpalatable for the Christian. First, it might suggest certain metaphysical views whichprima faciecall key tenets of orthodox Christianity into question. Secondly, mystical experience might be understood as the ‘inner meaning’ of Christianity which renders the better part of orthodox Christian belief equally problematic (as evidenced in three Christian mystics I discuss). I then conclude with a reflection on how the discussion might proceed, suggesting once more that Christian analytic theologians and philosophers of religion have scarcely begun to ask the relevant questions, let alone answer them in any persuasive manner.
Acute Myeloid Leukemia in Children: Emerging Paradigms in Genetics and New Approaches to Therapy
Authors: Conneely Shannon E. , Stevens Alexandra M. 
Published: January 2021

Abstract
Purpose of Review
Acute myeloid leukemia (AML) in children remains a challenging disease to cure with suboptimal outcomes particularly when compared to the more common lymphoid leukemias. Recent advances in the genetic characterization of AML have enhanced understanding of individualized patient risk, which has also led to the development of new therapeutic strategies. Here, we review key cytogenetic and molecular features of pediatric AML and how new therapies are being used to improve outcomes.

Recent Findings
Recent studies have revealed an increasing number of mutations, including WT1, CBFA2T3-GLIS2, and KAT6A fusions, DEK-NUP214 and NUP98 fusions, and specific KMT2A rearrangements, which are associated with poor outcomes. However, outcomes are starting to improve with the addition of therapies such as gemtuzumab ozogamicin and FLT3 inhibitors, initially developed in adult AML.

Summary
The combination of advanced risk stratification and ongoing improvements and innovations in treatment strategy will undoubtedly lead to better outcomes for children with AML.
Quantitative Sensory Testing to Predict Postoperative Pain
Authors: Braun Matthias , Bello Corina , Riva Thomas , Hönemann Christian , Doll Dietrich , Urman Richard D. , Luedi Markus M. 
Published: January 2021

Abstract
Purpose of Review
We review the relevance of quantitative sensory testing (QST) in light of acute and chronic postoperative pain and associated challenges.

Recent Findings
Predicting the occurrence of acute and chronic postoperative pain with QST can help identify patients at risk and allows proactive preventive management. Generally, central QST testing, such as temporal summation of pain (TSP) and conditioned pain modulation (CPM), appear to be the most promising modalities for reliable prediction of postoperative pain by QST. Overall, QST testing has the best predictive value in patients undergoing orthopedic procedures.

Summary
Current evidence underlines the potential of preoperative QST to predict postoperative pain in patients undergoing elective surgery. Implementing QST in routine preoperative screening can help advancing traditional pain therapy toward personalized perioperative pain medicine.
Localized Water Quality Improvement in the Choptank Estuary, a Tributary of Chesapeake Bay
Authors: Fisher Thomas R. , Fox Rebecca J. , Gustafson Anne B. , Koontz Erika , Lepori-Bui Michelle , Lewis James 
Published: January 2021

AbstractChesapeake Bay has a long history of nutrient pollution resulting in degraded water quality. However, we report improvements in chlorophyll a in surface waters and dissolved oxygen in bottom waters at one of three estuarine stations in the Choptank tributary of Chesapeake Bay. We updated a previous nutrient budget for the estuary constructed for reference year 1998 using rates of atmospheric deposition, inputs of watershed diffuse sources (primarily agriculture), and discharges of point sources (primarily human waste) for reference year 2017. Parallel trends suggest that improvements in water quality at the one station were likely due to 20% reductions in direct atmospheric deposition on the estuary’s surface and 78–95% reductions in wastewater N and P due to installation of tertiary treatment. The agricultural sector, the dominant source of N and P, appeared to provide little contribution to improved water quality during this period. Although efforts to reduce nutrient losses from agriculture are common throughout the Choptank basin, widespread reductions from agricultural diffuse sources could make large contributions to improved water quality at all stations in the estuary. The response in the Choptank is similar to those observed elsewhere in the USA, Europe, Australia, and New Zealand due to improved wastewater treatment. Similar to our findings, the upper Potomac River of Chesapeake Bay saw improvements driven by reductions in atmospheric deposition. Unfortunately, few studies elsewhere have shown improvements in water quality due to agricultural management. The data presented here indicate that public and industrial investments in reductions of atmospheric emissions and upgrades to wastewater treatment plants have improved estuarine water quality in the Choptank.