bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mundgesundheitstrends im Kindesalter
Authors: Schmoeckel Julian , Santamaría Ruth M. , Basner Roger , Schankath Elisabeth , Splieth Christian H. 
Published: June 2021

ZusammenfassungFür die Beschreibung der aktuellen epidemiologischen Trends der Karieserfahrung bei Kindern in Deutschland wurden die Mundgesundheitsdaten primär anhand der Epidemiologischen Begleituntersuchungen zur Gruppenprophylaxe (DAJ-Studie) für das Schuljahr 2015/2016 dargestellt. Hier standen Kariesdaten von 301.684 Kindern verteilt auf 3 verschiedene Altersgruppen zur Verfügung. Für die Trends in der Kariesentwicklung wurden zudem weitere in Deutschland durchgeführte nationale und regionale Studien herangezogen.Karies an Milchzähnen tritt schon sehr früh auf (bereits 10–17 % der 3‑Jährigen sind betroffen) und ist auch unter 6‑ bis 7‑Jährigen noch weitverbreitet (ca. 40–60 %). Sehr hoch ist dabei der Anteil nicht sanierter kariöser Milchzähne (3-Jährige: 73,9 %, 6‑ bis 7‑Jährige: 42,5 %). Bei den 6‑ bis 7‑Jährigen sind in den letzten 10 Jahren außerdem kaum noch Verbesserungen zu verzeichnen. Die Karieswerte der erstmals im Rahmen der DAJ-Studie national untersuchten 3‑Jährigen liegen in dem Bereich der Werte aus bisherigen lokalen Studien der letzten Jahrzehnte, bei den 6‑ bis 7‑Jährigen konvergieren die Werte regional. Bei den 12-Jährigen ist die mittlere Karieserfahrung im bleibenden Gebiss in den letzten knapp 20 Jahren um etwa 80 % gesunken. Damit liegt Deutschland hinsichtlich der Mundgesundheit dieser Altersgruppe weltweit im Spitzenbereich.Bezüglich der Mundgesundheit im Milchgebiss besteht in Deutschland dennoch ein deutliches Optimierungspotenzial. Kürzlich implementierte präventive Maßnahmen adressieren dieses Problem bereits, sodass weitere Verbesserungen ähnlich den Erfolgen im bleibenden Gebiss realistisch erscheinen und zu erwarten sind.
Screening and Analysis of Multiclass Veterinary Drug Residues in Animal Source Foods using UPLC-Q-Exactive Orbitrap/MS
Authors: Zhao Wentao , Jiang Rui , Guo Wenping , Guo Chao , Li Shilei , Wang Juanqiang , Wang Shouwei , Li Yingying 
Published: June 2021

AbstractA rapid, simple, and sensitive method of detecting veterinary drug residues in animal food sources, including poultry and pork, was developed and validated. The method was optimized for over 155 veterinary drugs of 21 different classes. Sample pretreatment included a simple solid-liquid extraction step with 0.2% formic acid-acetonitrile-water and a purification step with a PRiME HLB (hydrophile-lipophile balance) solid-phase extraction cartridge. Data were collected using ultra-high-performance liquid chromatography coupled to Quadrupole-Exactive Orbitrap mass spectrometry. The limits of detection of 155 veterinary drugs ranged from 0.1 µg/kg to 10 µg/kg. The recovery rates were between 79.2 and 118.5 % in all matrices studied, with relative standard deviation values less than 15% (n = 6). The evaluated method allows the reliable screening, quantification, and identification of 155 veterinary drug residues in animal source food and has been successfully applied in authentic samples.
Trading with richer and poorer countries: trade integration and regional inequality in Greece
Authors: Rodríguez-Pose Andrés , Sotiriou Alexandra 
Published: June 2021

AbstractThis paper examines the link between increased trade and regional GDP growth across the regional income distribution in Greece during the post-EMU period (2000–2013). By means of quantile regression techniques, panel fixed effects and system generalized method of moments (GMM), we disentangle the effects of EU trade—trading with generally richer countries—versus global trade—in the case of Greece, mostly trading with poorer countries—at several points of the regional income distribution to identify differences in trade elasticities. The analysis finds that the impact of EU trade is highly heterogeneous and mainly affects negatively the economy of the richer regions in Greece. In contrast, the effects of EU trade display insignificant results for the lower-income regions, attributed to the absence of direct substitution effects.
Lesions of abdominal connectives reveal a conserved organization of the calling song central pattern generator (CPG) network in different cricket species
Authors: Lin Chu-Cheng , Hedwig Berthold 
Published: June 2021

AbstractAlthough crickets move their front wings for sound production, the abdominal ganglia house the network of the singing central pattern generator. We compared the effects of specific lesions to the connectives of the abdominal ganglion chain on calling song activity in four different species of crickets, generating very different pulse patterns in their calling songs. In all species, singing activity was abolished after the connectives between the metathoracic ganglion complex and the first abdominal ganglion A3 were severed. The song structure was lost and males generated only single sound pulses when connectives between A3 and A4 were cut. Severing connectives between A4 and A5 had no effect in the trilling species, it led to an extension of chirps in a chirping species and to a loss of the phrase structure in two Teleogryllus species. Cutting the connectives between A5 and A6 caused no or minor changes in singing activity. In spite of the species-specific pulse patterns of calling songs, our data indicate a conserved organisation of the calling song motor pattern generating network. The generation of pulses is controlled by ganglia A3 and A4 while A4 and A5 provide the timing information for the chirp and/or phrase structure of the song.
Body composition and mortality in patients undergoing endovascular treatment for peripheral artery disease
Authors: Itagaki Tadashi , Ebisawa Soichiro , Otagiri Kyuhachi , Kato Tamon , Miura Takashi , Kanzaki Yusuke , Abe Naoyuki , Yokota Daisuke , Yanagisawa Takashi , Senda Keisuke , Okina Yoshiteru , Wakabayashi Tadamasa , Oyama Yushi , Karube Kenichi , Machida Keisuke , Takeuchi Takahiro , Saigusa Tatsuya , Motoki Hirohiko , Kitabayashi Hiroshi , Kuwahara Koichiro 
Published: June 2021

AbstractAn inverse correlation between body mass index and mortality in patients with peripheral artery disease (PAD) has been reported. However, little information is available regarding the impact of body composition on the clinical outcomes in patients with PAD. This study evaluated the relationships between the lean body mass index (LBMI), body fat % (BF%), and mortality and major amputation rate in patients with PAD. We evaluated 320 patients with PAD after endovascular treatment (EVT) enrolled from August 2015 to July 2016 and divided them into low and high LBMI and BF% groups based on their median values (17.47 kg/m2and 22.07%, respectively). We assessed 3-year mortality and major amputation for the following patient groups: Low LBMI/Low BF%, Low LBMI/High BF%, High LBMI/Low BF%, and High LBMI/High BF%. During the median 3.1-year follow-up period, 70 (21.9%) patients died and 9 (2.9%) patients experienced major amputation. The survival rate was lower in the Low LBMI than in the High LBMI group, and was not significantly different between the Low and High BF% groups. Survival rates were lowest in the Low LBMI/Low BF% group (57.5%) and highest in the High LBMI/High BF% group (94.4%). There were no significant differences in major amputation rate between the Low LBMI and High LBMI groups, and between the Low BF% and High BF% groups. The Low LBMI and Low BF% groups were associated with an increased risk of mortality after adjustment for age, sex, frailty and conventional risk factors [hazard ratio (HR): 4.02; 95% confidence interval (CI) 2.10–7.70;p < 0.001 and HR: 4.48; 95% CI 1.58–12.68,p = 0.005, respectively], for age, sex, hemodialysis, and prior cerebral cardiovascular disease (HR: 3.63; 95% CI 1.93–6.82;p < 0.001 and HR: 4.03; 95% CI 1.43–11.42,p = 0.009, respectively) and for age, sex, and laboratory date (HR: 3.97; 95% CI 1.88–8.37;p < 0.001 and HR: 3.31; 95% CI 1.15–9.53,p = 0.026, respectively). In conclusion, Low LBMI and Low BF% were associated with poor prognosis in patients undergoing EVT for PAD, and mortality was the lowest in the High LBMI/High BF% group compared with other body composition groups.
Hepatitis-E-Virus-Infektion bei einem Patienten mit rheumatoider Arthritis unter Baricitinib-Therapie
Authors: Valor-Méndez Larissa , Manger Bernhard , Schett Georg , Kleyer Arnd 
Published: June 2021

ZusammenfassungEs wurde ein Patient mit rheumatoider Arthritis (RA) vorgestellt, der unter der Therapie mit dem Januskinase-1/2-Inhibitor Baricitinib eine Infektion mit dem Hepatitis-E-Virus (HEV) entwickelte. Unser Patient hatte bei seiner vierteljährlichen Routineuntersuchung deutlich erhöhte Transaminasen bei einer unauffälligen körperlichen Untersuchung. Es fanden sich Antikörper der IgM- und IgG-Klasse gegen HEV und ein erhöhtes C‑reaktives Protein (CRP) sowie HEV-RNA mittels Real-Time-PCR, was auf eine frische HEV-Infektion hinwies. Baricitinib wurde sofort abgesetzt. Die ausführliche Anamnese ergab, dass der Patient Tage vor der Konsultation Rindertartar verzehrt hatte, ohne dass gastrointestinale Symptome oder Fieber aufgetreten waren. Im weiteren Verlauf erholte sich der Patient vollständig, und die Leberfunktionstests und das CRP normalisierten sich innerhalb von 3 Monaten. Baricitinib wurde daraufhin wieder eingenommen. Bisher wurden nur wenige Daten zu HEV-Infektionen bei RA-Patienten, die mit JAK-Inhibitoren behandelt wurden, publiziert.
Total hip arthroplasty for destructive septic arthritis of the hip using a two-stage protocol without spacer placement
Authors: Hipfl Christian , Karczewski Daniel , Oronowicz Jakub , Pumberger Matthias , Perka Carsten , Hardt Sebastian 
Published: June 2021

Abstract
Introduction
The optimal treatment of patients with a degenerative joint disease secondary to an active or chronic septic arthritis of the hip is unclear. The aim of the present study was to report on our experience with two-stage total hip arthroplasty (THA) using a contemporary treatment protocol without spacer insertion.

Materials and methods
Our prospective institutional database was used to identify all patients with degenerative septic arthritis treated with a non-spacer two-stage protocol between 2011 and 2017. Clinical outcomes included interim revision, periprosthetic infection (PJI) and aseptic revision rates. Restoration of leg-length and offset were assessed radiographically. Modified Harris hip score (mHHS) were obtained. Treatment success was defined using the modified Delphi consensus criteria. Mean follow-up was 62 months (13–110).

Results
A total of 33 patients with a mean age of 60 years (13–85) were included. 55% of the cohort was male and average Charlson Comorbidity Index (CCI) was 3.7 (0–12). 21 patients (64%) had an active/acute infection and 12 patients (36%) were treated for chronic/quiescent septic arthritis. Overall, 11 patients (33%) had treatment failure, including 5 patients who failed to undergo THA, 2 interim re-debridement for persistent infection, and 4 patients who developed PJI after an average of 7 months (0.3–13) following THA. The most common identified pathogen was Staphylococcus aureus (42.4%). No aseptic revision was recorded following THA. Leg-length and offset were successfully restored. Mean mHHS improved from 35.2 points to 73.4 points.

Conclusion
Two-stage THA without spacer placement is a viable treatment option for destructive septic arthritis of the hip, demonstrating comparable rates of infection control and functional outcome. However, definitive resection arthroplasty is not uncommon in these often critically ill patients.
Comorbidities and treatment patterns in adult patients with atopic dermatitis: results from a nationwide multicenter study
Authors: Campanati A. , Bianchelli T. , Gesuita R. , Foti C. , Malara G. , Micali G. , Amerio P. , Rongioletti F. , Corazza M. , Patrizi A. , Peris K. , Pimpinelli N. , Parodi A. , Fargnoli M. C. , Cannavo S. P. , Pigatto P. , Pellacani G. , Ferrucci S. M. , Argenziano G. , Cusano F. , Fabbrocini G. , Stingeni L. , Potenza M. C. , Romanelli M. , Bianchi L. , Offidani A. ,   and collaborators, Romita P. , Musumeci M. L. , Piras V. , Borghi A. , Loi C. , Gori N. , Prigano F. , Gallo R. , Esposito M. , Campitello A. , Bolzano L. , Tavecchio S. , Calabrese G. , Di Costanzo L. , Hansel K. , Skroza N. , Tolino E. , Tonini G. , Talamonti M. 
Published: June 2021

AbstractAdult atopic dermatitis (adult AD) is a systemic inflammatory disorder, whose relationship with immune-allergic and metabolic comorbidities is not well established yet. Moreover, treatment of mild-to-moderate and severe atopic dermatitis needs standardization among clinicians. The aim of this study was to evaluate the distribution of comorbidities, including metabolic abnormalities, rhinitis, conjunctivitis, asthma, alopecia and sleep disturbance, according to severity of adult AD, and describe treatments most commonly used by Italian dermatologists. Retrospective, observational, nationwide study of adult patients over a 2-year period was performed. Clinical and laboratory data were obtained through review of medical records of patients aged ≥ 18 years, followed in 23 Italian National reference centres for atopic dermatitis between September 2016 and September 2018. The main measurements evaluated were disease severity, atopic and metabolic comorbidities, treatment type and duration. Six-hundred and eighty-four adult patients with AD were included into the study. Atopic, but not metabolic conditions, except for hypertension, were significantly associated with having moderate-to-severe AD in young adult patients. Disease duration was significantly associated with disease severity. Oral corticosteroids and cyclosporine were the most widely used immunosuppressant. Our study seems confirm the close relationship between adult AD and other atopic conditions, further long-term cohort studies on patients affected by adult AD need to be performed to evaluate the complex relationship between adult AD disease severity and metabolic comorbidities.
Associations between combinations of job demands and job control among 6,16,818 people aged 55–64 in paid work with their labour market status 11 years later: a prospective cohort study
Authors: Farrants Kristin , Head J. , Framke E. , Rugulies R. , Alexanderson K. 
Published: June 2021

Abstract
Background
Given current discussions about extending working lives, more knowledge is needed on working conditions associated with labour market status in older age.

Objective
To explore associations between combinations of job demands and job control among workers aged 55–64 years and their labour market status 11 years later.

Methods
A population-based prospective cohort study using nationwide register data. The 616,818 individuals in Sweden aged 55–64 who in 2001 were in paid work were categorised using a job exposure matrix based on tertiles (reference = medium control/medium demands). Participants were followed up in 2012 regarding their main labour market status (paid work, old-age pension, no income/social assistance, sickness absence/disability pension, emigrated, dead; reference = old-age pension) using multinomial logistic regression for odds ratios (OR) and 95% confidence intervals (CI). The fully adjusted analyses included adjustment for sociodemographic factors and unemployment or sickness absence/disability pension for more than half the year in 2001.

Results
Those in occupations with low job control at baseline were less likely to be in paid work at follow-up (OR low demands/low control 0.74, CI 0.71–0.78; high demands/low control 0.81, CI 0.75–0.87). Those in occupations with baseline high demands were less likely to have no income/social assistance at follow-up (OR high demands/low control 0.71, CI 0.52–0.96; high demands/high control 0.59, CI 0.47–0.75).

Conclusion
Job demands and control when aged 55–64 were associated with labour market status 11 years later: high control was associated with greater chance of being in paid work, and high demands were associated with lower risk of no income/social assistance.
Order Conditions for Sampling the Invariant Measure of Ergodic Stochastic Differential Equations on Manifolds
Authors: Laurent Adrien , Vilmart Gilles 
Published: June 2021

AbstractWe derive a new methodology for the construction of high-order integrators for sampling the invariant measure of ergodic stochastic differential equations with dynamics constrained on a manifold. We obtain the order conditions for sampling the invariant measure for a class of Runge–Kutta methods applied to the constrained overdamped Langevin equation. The analysis is valid for arbitrarily high order and relies on an extension of the exotic aromatic Butcher-series formalism. To illustrate the methodology, a method of order two is introduced, and numerical experiments on the sphere, the torus and the special linear group confirm the theoretical findings.
The emotional heart: prospective associations of anger, depression, and anxiety as risk factors for myocardial infarction in a 22-year follow-up of a working cohort of middle-aged men
Authors: Vella Rebecca , Sloan Richard P. , Eriksson Bo , Dimberg Lennart 
Published: June 2021

Abstract
Aim
The study aim was to further clarify the relationship between psychological factors and myocardial infarction (MI) by simultaneously examining anger, depression, and anxiety as risk factors for incident MI in a healthy working sample.

Subject and method
Baseline measurements of psychological variables were assessed through a self-reported questionnaire in a healthy cohort of 968 middle-aged men working at the Volvo Corporation. Single-item questions assessed depression and anxiety. Anger was assessed by the Trait Anger subscale of the Spielberger State-Trait Anger Expression Inventory. The endpoint was incident MI verified by national registers or medical records with follow up after 22 years. The main outcome was computed through logistic regression, reported as odds ratios. Additional correlation analyses were performed between psychological variables and coronary risk factors.

Results
None of the psychological variables was significantly associated with the outcome; thus, the results failed to show an association between anger, depression, or anxiety and incident MI in this sample. There were some significant, but weak, correlations between psychological factors and negative health behaviors. Other components of traditional risk scoring instruments did not correlate with the psychological factors.

Conclusion
A cohort restricted to middle-age healthy men limits applicability. However, our failure to replicate earlier results of population samples suggests a need for further research on associations between psychological factors and MI in healthy samples.
Let the people decide: citizen deliberation on the role of GMOs in Mali’s agriculture
Authors: Pimbert Michel P. , Barry Boukary 
Published: June 2021

AbstractThis paper describes and critically reflects on a participatory policy process which resulted in a government decision not to introduce genetically modified (GM) cotton in farmers’ fields in Mali (West Africa). In January 2006, 45 Malian farmers gathered in Sikasso to deliberate on GM cotton and the future of farming in Mali. As an invited policy space convened by the government of Sikasso region, this first-time farmers' jury was unique in West Africa. It was known as l’ECID—Espace Citoyen d’Interpellation Démocratique (Citizen’s Space for Democratic Deliberation)—and it had an unprecedented impact on the region. In this Deliberative and Inclusive Process (DIP), the ECID combined the citizens’ jury method with indigenous methods for debate and dialogue, including the traditional African palaver. The ECID brought together male and female producers representing every district in the Sikasso region of southern Mali, specialist witnesses from various continents and a panel of independent observers, as well as resource persons and members of the national and international press and media. As an experiment in deliberative democracy, the ECID of Sikasso aimed to give men and women farmers the opportunity to share knowledge on the benefits and risks of GM cotton, and make policy recommendations on the future of GM technology in Malian agriculture. Designed as a bottom-up and participatory process, the ECID’s outcomes significantly changed national policy on the release of GM technology and have had an enduring influence in Mali. In this paper, we describe our positionality as action researchers and co-organisers of the ECID. We explain the methodology used for the ECID of Sikasso and critically reflect on the safeguards that were put in place to ensure a balanced and trustworthy deliberative process. The ECID and its key outcomes are discussed in the context of the political economy of GM cotton in West Africa. Last, we briefly highlight the relevance of the ECID for current international debates on racism in the theory and practice deliberative democracy; the production of post-normal transdisciplinary knowledge for technology risk-assessments; and the politics of knowledge in participatory policy-making for food and agriculture.
Measuring and eliminating the bullwhip in closed loop supply chains using control theory and Internet of Things
Authors: Papanagnou Christos I. 
Published: June 2021

AbstractClosed-loop supply chains are complex systems as they involve the seamless backward and forward flow of products and information. With the advent of e-commerce and online shopping, there has been a growing interest in product returns and the associated impact on inventory variance and the bullwhip effect. In this paper, a novel four-echelon closed-loop supply chain model is presented, where base-stock replenishment policies are modelled by means of a proportional controller. A stochastic state-space model is implemented, initially to capture the supply chain dynamics while the model is analysed under stationarity conditions with the aid of a covariance matrix. This allows the bullwhip effect to be expressed as a function of replenishment policies and product return rates. Next, an optimisation method is introduced to study the impact of the Internet of Things on inventory variance and the bullwhip effect. The results show that the Internet of Things can reduce costs associated with inventory fluctuations and eliminate the bullwhip effect in closed-loop supply chains.