bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mengasuh Anak Usia Prasekolah vs Anak Usia Sekolah Dasar : Manakah yang Lebih Menimbulkan Stres Pengasuhan pada Ibu?
Authors: Kumalasari Dewi , Gani Izmiyah Afaf Abdul 
Published: August 2021

ABSTRACTPreschool-age and school-age are phases that have different parenting challenges, which can trigger parenting stress on mothers. This study aimed to examine the parenting stress differences between mothers of preschoolers and mothers of school-aged children. This research used a quantitative approach with a cross-sectional design. Parenting stress is measured through the Parental Stress Scale (PSS) instrument. This study involved 249 respondents who were selected through convenience sampling methods. Analysis of the different tests with the Mann Withney technique showed that there were significant differences in parenting stress from the two groups. Mothers of school-aged children are found to experience higher parenting stress than mothers of preschool-aged children. Further studies involving culture-related variables and longitudinal design are suggested. ABSTRAKUsia prasekolah dan usia sekolah dasar merupakan fase yang memiliki tantangan pengasuhan yang berbeda, yang dapat memicu stres pengasuhan pada Ibu. Penelitian ini bertujuan untuk melihat perbedaan stres pengasuhan pada Ibu yang mengasuh anak usia prasekolah dan usia sekolah dasar. Penelitian ini menggunakan pendekatan kuantitatif dengan desain cross sectional. Stres pengasuhan diukur melalui instrument Parental Stres Scale (PSS). Penelitian ini melibatkan 249 responden yang dipilih melalui metode convenience sampling. Analisis uji beda dengan teknik Mann Withney menunjukkan bahwa ada perbedaan stres pengasuhan yang signifikan dari dua kelompok tersebut. Ibu yang mengasuh anak usia sekolah ditemukan mengalami stres pengasuhan yang lebih tinggi daripada ibu yang mengasuh anak usia prasekolah. Untuk pengembangan studi, pelibatan variabel yang terkait dengan budaya dan penggunaan desain longitudinal disarankan.
Pengaruh Konten Radikal Terhadap Sikap Radikalisme (Analisis Berdasarkan Theory of Planned Behavior dari Ajzen dan Fishbein)
Authors: Mubin Nuril , Setyaningsih Setyaningsih 
Published: August 2021

ABSTRACTThis study aims to determine the effect of radical content on the attitude of radicalism (analysis based on the theory of planned behavior of Ajzen and Fishbein). This study uses a quantitative approach. The number of samples in this study were users of active social media and following radical content with a total of 393 people. Sampling using purposive sampling technique (non-probability sampling). The instruments in this study are the scale of radical content and the scale of radicalism. The analysis of the data used is simple linear regression using the 23.0 for windows SPSS (statistical product and service solution) program. The results of this study indicate that the influence of radical content on radicalism is determined. Based on F count of 806.47 and probability of probability 0,000 (0,000 0.05) which means that the hypothesis is accepted, therefore there is a positive influence of radical content on the attitude of radicalism. The amount of the contribution or effective contribution of the influence of radical content on radicalism attitudes is 67,3% while the remaining 32,7% is influenced by other factors not measured in this study. ABSTRAKPenelitian ini bertujuan untuk melihat pengaruh konten radikal terhadap sikap radikalisme (analisis berdasarkan Teori Planned Behavior dari Ajzen Fishbein). Penelitian ini menggunakan pendekatan kuantitatif. Sample dalam penelitian ini berjumlah 393 orang yang aktif mengikuti konten radikal di media sosial. Teknik sampling yaitu Purpusive sampling (non-probability sampling). Alat ukur dalam penelitian ini menggunakan skala konten radikal dan skala sikap radikalisme. Analisis data yang digunakan regresi linier, SPSS seri 23. Hasil dari penelitian ini adalah ada pengaruh positif konten radikal terhadap sikap radikalisme. Didasarkan pada hasil hitung F= 806,47 dan probabilitas 0.000 (0.000 0.05). Sumbangan efektif konten radikal terhadap sikap radikalisme sebesar 67,3 % sementara sisanya 32,7% dipengaruhi faktor lain.
Pengaruh Body Shaming terhadap Kecenderungan Anorexia Nervosa pada Remaja Perempuan di Surabaya
Authors: Sari Tri Indah , Rosyidah Rezkiyah 
Published: August 2021

ABSTRACTThere are many dramatic changes in adolescence, one of them is the physical changes in which adolescent girls are less satisfied with their bodies due to increased amount of fat. There is an assumption that having a thin body will be easier to adapt to the social environment, influencing adolescents in making a decision to go on a diet even though it causes a tendency to anorexia nervosa. This research was conducted to knowing the effect of body shaming on the tendency of anorexia nervosa in adolescent girls in Surabaya. This study uses a quantitative approach where the respondents in this study were adolescent girls who experienced the tendency of anorexia nervosa in the city of Surabaya with a total of 349 respondents. The instruments in this study were the body shaming scale and the tendency scale for anorexia nervosa. This study used to simple linear regression test to analyze data (with SPSS 24 for windows program). The results of the study show the value of F = 54.172; P = 0.00, and R = 0.135. This means that there is an effect of body shaming on the tendency of anorexia nervosa in teenage girls in Surabaya. ABSTRAK Banyak perubahan dramatis di usia remaja, salah satunya adalah perubahan fisik dimana remaja perempuan kurang puas dengan tubuhnya terkait dengan meningkatnya jumlah lemak. Adanya anggapan bahwa memiliki tubuh kurus akan lebih mudah beradaptasi dengan lingkungan sosial, mempengaruhi remaja dalam mengambil suatu keputusan untuk melakukan diet meskipun menimbulkan kecenderungan anorexia nervosa. Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh body shaming terhadap kecenderungan anorexia nervosa pada remaja perempuan di Surabaya. Penelitian ini menggunakan pendekatan kuantitatif dimana responden dalam penelitian ini adalah remaja perempuan yang mengalami kecenderungan anorexia nervosa di kota Surabaya dengan jumlah 349 responden. Instrumen dalam penelitian ini adalah skala body shaming dan skala kecenderungan anorexia nervosa. Analisis yang digunakan dalam penelitian ini adalah uji regresi linier sederhana dengan bantuan program SPSS 24 for windows dimana hasil penelitian menunjukkan nilai F = 54,172; P = 0,00, dan R = 0,135. Artinya terdapat pengaruh body shaming terhadap kecenderungan anorexia nervosa pada remaja perempuan di Surabaya.
Tracing tumor evolution and subtype specification in pancreatic cancer
Authors: Rajbhandari Nirakar , Hamilton Michael , Quintero Cynthia , Ferguson L. Paige , Fox Ray , Schurch Christian M. , Wang Jun , Nakamura Mari , McDermott Matthew , Pettit Hannah , Kritzik Marcie , Han Haiyong , Cridebring Derek , Tsai Susan , Lowy Andrew M. , Wechsler-Reya Robert J. , Von Hoff Daniel D. , Newman Aaron M. , Reya Tannishtha 
Published: August 2021

Abstract
Identifying the cells from which cancers arise, and the paths they take towards malignancy, is critical for understanding the molecular basis of tumor initiation and progression. To understand if stem and progenitor cells can serve as cells of origin for cancer, we created a model in which the CreERT2 recombinase was knocked into the endogenous locus of the stem cell determinant Msi2. When crossed to a conditional CAG-LSL-MycT58A model, Msi2-CreERT2 mice developed a diversity of tumors across tissues, including multiple pancreatic cancer subtypes: pancreatic ductal adenocarcinoma (PDAC), adenosquamous carcinoma of the pancreas (ASCP), acinar cell carcinoma (ACC), and rare anaplastic tumors. Using single cell analysis, we traced the temporal changes that occurred as normal Msi2+ cells evolved through a pre-cancerous stage to PDAC, ASCP or ACC. These results revealed that Msi2+ cells were present predominantly in pancreatic ducts and exhibited heterogeneous differentiation states in the normal pancreas. At initiation, Myc triggered oncogenic transformation in the most undifferentiated subset leading to the rise of pre-cancer cells with multi-lineage properties. Subsequently, these pre-cancer cells were driven along different fates by epigenetically activated transcriptional programs with genomic changes amplifying the progression into distinct pancreatic cancer subtypes. Finally, integrating transcriptomic and functional genomic approaches in this new model allowed us to define Ifne, Ifitm3, Atf3, Hmmr, and Raet1e as novel functional dependencies of ASCP, giving us unique insight into the most lethal of pancreatic malignancies. These data show that multiple pancreatic cancer subtypes can arise from a common pool of pre-malignant cells and provide a powerful molecular framework to understand the programs that shape divergent fates in pancreas cancer and develop approaches for early detection and interception.
Affine connection representation of gauge fields
Authors: Man Zhao-Hui 
Published: August 2021

Abstract
There are two ways to unify gravitational field and gauge field. One is to represent gravitational field as principal bundle connection, and the other is to represent gauge field as affine connection. Poincaré gauge theory and metric-affine gauge theory adopt the first approach. This paper adopts the second. In this approach: (i) Gauge field and gravitational field can both be represented by affine connection; they can be described by a unified spatial frame. (ii) Time can be regarded as the total metric with respect to all dimensions of internal coordinate space and external coordinate space. On-shell can be regarded as gradient direction. Quantum theory can be regarded as a geometric theory of distribution of gradient directions. Hence, gauge theory, gravitational theory and quantum theory obtain the same geometric foundation and a unified description of evolution. (iii) Coupling constants, chiral asymmetry, PMNS mixing and CKM mixing can appear spontaneously as geometric properties in affine connection representation. It is remarkable that PMNS mixing and CKM mixing can be interpreted as a spontaneous geometric consequence of symmetry reduction, so they are not necessary to be regarded as direct postulates in the Lagrangian anymore. (iv) The unification theory of gauge fields that are represented by affine connection can avoid the problem that a proton decays into a lepton in theories such as SU(5). (v) There exists a possible geometric interpretation to the color confinement of quarks. In the affine connection representation, we can get better interpretations of the above physical properties, therefore, to represent gauge fields by affine connection is probably a necessary step towards the ultimate theory of physics.
Spatiotemporal Analysis of Drought by CHIRPS Precipitation Estimates
Authors: Aksu Hakan , Cavus Yonca , Eris Ebru , Aksoy Hafzullah , Akgul Mehmet Ali , Turker Seyhmus 
Published: August 2021

Abstract
Drought is one of the most devastating worldwide natural hazards that can occur in all climatic zones and cause considerable losses affecting many water-needing sectors. It is also one of the most complex and least understood hazards due to its high heterogeneity in space and variability in time. Therefore, for a proper spatial and temporal drought analysis, spatially dense and uniformly distributed ground-based precipitation data are needed. In practice, such data are generally lacking either due to missing data or to the nonuniform and scarce spatial distribution of ground stations. This gives a great potential to the Climate Hazards Group Infrared Precipitation with Station (CHIRPS) data with a long period and high resolution for using in drought studies. The CHIRPS data also allow to tackle with the problem of sparse, unevenly distributed and erratic ground stations. Based on the CHIRPS data, the study aims to assess the drought condition over Kucuk Menderes River Basin in the western part of Turkey. The analysis was performed considering the seasonality as well as the spatial and temporal change in the drought characterization based on the Standardized Precipitation Index (SPI) calculated at 3-month (seasonal) time scale. Results showed that the CHIRPS and ground stations were highly correlated except for summer despite the overall good performance in the basin. The CHIRPS can properly capture drought characteristics. Droughts have a within-year variability in time and an insignificant variability in space over the basin while the over-year variability shows a significant decreasing trend which could be a signal for more severe droughts after being accumulated over years in the future. The study demonstrates the usefulness of CHIRPS in drought analysis due to the fact that ground-based data are still not at a level dense and long enough to understand the process precisely both in time and space.
Early Changes in Gene Expression Profiles in AML Patients During Induction Chemotherapy
Authors: Jakobsen Ingrid , Sundkvist Max , Björn Niclas , Gréen Henrik , Lotfi Kourosh 
Published: August 2021

Abstract
Background: Elucidation of the genetic mechanisms underlying treatment response to standard induction chemotherapy in AML patients is warranted, in order to aid in risk-adapted treatment decisions as novel treatments are emerging. In this pilot study, we explored the treatment-induced expression patterns in a small cohort of AML patients by analyzing differential gene expression (DGE) over the first two days of induction chemotherapy.Methods: Blood samples were collected from ten AML patients at baseline (before treatment initiation) and during the first two days of treatment (Day 1; approximately 24 h, and Day 2; approximately 48 h after treatment initiation, respectively) and RNA was extracted for subsequent RNA sequencing. DGE between time points were assessed by pairwise analysis using the R package edgeR version 3.18.1 in all patients as well as in relation to treatment response (complete remission, CR, vs non-complete remission, nCR). Ingenuity Pathway Analysis (Qiagen) software was used for pathway analysis and visualization.Results: After initial data quality control, two patients was excluded from further analysis, resulting in a final cohort of eight patients with data from all three timepoints. DGE analysis demonstrated activation of pathways with genes directly or indirectly associated with NF-κB signaling. Significant activation of the NF-κB pathway was seen in 50% of the patients two days after treatment start, while iNOS pathway effects could be identified already after one day. nCR patients displayed activation of pathways associated with cell cycle progression, oncogenesis and anti-apoptotic behavior, including the STAT3 pathway and Salvage pathways of pyrimidine ribonucleotides. Notably, a significant induction of cytidine deaminase, an enzyme responsible for the deamination of Ara-C, could be observed between baseline and Day 2 in the nCR patients but not in patients achieving CR.Conclusions: In conclusion, we show that time-course analysis of gene expression represents a feasible approach to identify relevant pathways affected by standard induction chemotherapy in AML patients. This poses as a potential method for elucidating new drug targets and biomarkers for categorizing disease aggressiveness and evaluating treatment response. However, more studies on larger cohorts are warranted to elucidate the transcriptional basis for drug response.
Modification of Breast Cancer Milieu with Chemotherapy Plus Dendritic Cell Vaccines: An Approach to Select Best Therapeutic Strategies
Authors: Mejías Luis , López-Janeiro Álvaro , Córdoba Alicia , Sala Pablo , Solans Belén Pérez , Inogés Susana , de Cerio Ascensión López-Díaz , Hato Laura , Guillén-Grima Francisco , Fernández-Hidalgo Óscar , Cruz Susana De La , Lozano María Dolores , Idoate Miguel A. , Santisteban Marta 
Published: August 2021

Abstract
BackgroundThe addition of Dendritic cell vaccines (DCV) to neoadjuvant chemotherapy (NAC) could induce immune biomarker changes in those patients with residual disease (RD) by transforming tumor microenvironment.MethodsCore-diagnostic biopsies and surgical specimens from 80 patients (38 in the Vaccinated Group plus NAC (VG) and 42 in the Control Group (CG) treated only with NAC) were selected. We quantify TILs (CD8, CD4 and CD45RO) using Immunohistochemistry (IHC) and the Automated Cellular Imaging System (ACIS III) in the core-diagnostic biopsies and in the surgical specimen, to compare the amount of TILs in each group.ResultsA CD8 rise in TNBC samples was observed after NAC plus DCV, changing from 4.48% in the biopsy to 6.70% in the surgical specimen, not reaching statistically significant differences (p = 0.11). TNBC patients in the CG showed a TILs drop from 2.71% in the biopsy to 0.18% in the surgical specimen (p = 0.5). We also found that a 66.7% (4/6) of TNBC patients from VG registered an increase in TILs after treatment as compared with 20% (1/5) of TNBC patients in the CG (p=0.24). This phenomenon is not observed in the other biologic subtypes.An association between before NAC CD8 TILs (4% cut-off point ) and pathological complete response in VG was found in univariate and multivariate analysis (OR=1.41, IC95% 1.05-1.90; p=0.02, and OR=2.0, IC95% 1.05-3.9; p=0.03, respectively).ConclusionOur findings suggest that patients with TNBC especially benefit from the stimulation of the antitumor immune system by using DCV pulsed with tumor antigens.Trial registration: NCT01431196. Registred 19 May 2016. EudraCT 2009- 017402-36.
Attention Deficit Hyperactivity Disorder (ADHD) in Patients With Congenital Heart Disease (CHD)
Authors: Shahri Hassan Mottaghi Moghaddam , Eslamzadeh Mahboubeh , Yazdi Aazam Sadat Heydari 
Published: August 2021

Abstract
BackgroundIt is established that children with congenital heart disease (CHD) are more susceptible for suffering deficiencies in intellectual functioning, developmental problems, and academic performance difficulties. Neurodevelopmental disabilities, particularly executive function impairments, are currently the most prevalent long-term morbidity in the population with CHD. The aim of this study was to investigate the frequency of Attention deficit hyperactivity disorder (ADHD) in children with CHD. MethodsThis was a retrospective cohort study, which was performed between 2002-2018 in patients with CHD referred to Imam Reza hospital, Mashhad, Iran. Using the census method, all files for which ADHD diagnosis has been made according to DSM-IV or DSM-V criteria should be included in the study. Diagnosis of CHD was performed clinically and using an echocardiographic machine by an experienced pediatric cardiologist. Heart diseases were divided into two important (major) and non-important (minor) categories based on the need for follow-up and intervention. Demographic, clinical and para-clinical data of patients as well as the type of heart intervention were collected and analyzed.Results136 patients were enrolled in the study. The mean age of participants in the study was 59.12± 45.84 months at the time of diagnosis. Abnormal electroencephalogram (EEG) was reported in three cases (2.2%). There was significant correlation between prematurity and developmental delay (P=0.01). The mean of age was significantly different in patients with minor rather than patients with major cardiac disorders (P<0.05). The prevalence of ADHD in CHD population was high (31.6%).ConclusionThis study demonstrated that children born with CHD are at increased risk of suffering from ADHD.
Terahertz Waveguide-Based Pulse-Shaper System Analysis and Modeling
Authors: razavizadeh seyed mohammadreza , Sadeghzadeh Ramezanali , kashani Zahra Ghattan 
Published: August 2021

Abstract
In this paper, the transfer function of a passive waveguide-based terahertz pulse shaper is achieved using the time domain data provided by

the full-wave simulation of the structure. The fractional order of the transfer function is determined based on the time response resulting from an arbitrary excitation of the proposed pulse shaper. The full-wave electromagnetic numerical analyses are applied to attain the time-domain output data of the helical gold-ribbon dielectric-lined waveguide as the terahertz pulse shaper. In order to verify the simulation results, the proposed device has been examined using two different numerical methods which are the Finite Element Method (FEM) and the Finite Integral Technique (FIT). A good agreement was found between the results of FIT and FEM methods. The use of the system transfer function to analyze the structure is preferable to the full-wave simulation because of saving the execution time. Once the transfer function is determined, one could apply it for the subsequent time-domain analysis of the pulse shaper with various inputs.
Do Anomalous Stillbirths Have Risk To Be Delivered Preterm? A Cross-Sectional Study Conducted in Kandy, Sri Lanka
Authors: Alahakoon A. M. S. S. , Ratnayake C. J. , Karunakaran K. E. , Tennakoon S. U. B. 
Published: August 2021

Abstract
Stillbirths is one of major health issues in Sri Lankan context. This study aimed to explore the distribution of externally identifiable congenital anomalies according to their sex and the period of gestation and to estimate risk of stillbirth with or without congenital anomalies to be born pre-term or term. Sample size was 246. Due to extreme prematurity and maceration, 05 fetuses were excluded. Of 241 stillbirths, 36 (14.9%) had congenital anomalies and majority were females (n=23, 9.5%). The mean period of gestation was 31 weeks (SD=5.3). 12.5% with congenital anomalies were pre-term. 95% confidence interval (0.261-1.170) of risk estimate revealed that there is no statistically significant association between fetal sex and having congenital anomalies. Risk to be preterm stillbirth for the fetuses with congenital anomalies was 2.447 times (OR = 2.447) greater than the non-anomulous. Females were at high risk to acquire congenital anomalies. Congenital anomalies caused preterm stillbirths.
Global Dynamics and Optimal Design of a New Highly Efficient Nonlinear Energy Sink Based on Magnetic-Elastic Impacts with Negative Stiffness
Authors: Li Shuangbao , Wang Tingting , Chen Jianen 
Published: August 2021

Abstract
A new highly efficient elastic-impact bistable nonlinear energy sink (EI-BNES) based on magnetic-elastic impacts with negative stiffness and bistability is proposed and optimized through global dynamical analysis. The EI-BNES has better robustness and higher energy dissipation rates with nearly more than 96.5\% for broadband impulsive excitations than the traditional cubic NESs and single bistable NESs. The structure of negative stiffness impacts is realized by reasonable layout of permanent ring magnets and springs. A two-degree-of-freedom (two-DOF) elastic-impact system is established to describe the coupled nonlinear interaction between the main structure and the attached EI-BNES. A global Melnikov reduction analysis (GMRA) is proposed to study global dynamics and homoclinic bifurcations of the reduced two-dimensional subsystem, which is used to explain the mechanism of nonlinear targeted energy transfer (TET) and detect the threshold of impulsive amplitudes of EI-BNES for in-well and compound motions between in-well and cross-well resonance responses. A special type of saddle-center equilibrium points is also found in the non-smooth system of the EI-BNES and can be used to effectively increase the energy dissipation rates. The optimal design criterion of the tuned EI-BNES for better dissipation performance is also first discussed based on the GMRA and numerical techniques for calculating the Melnikov function of the non-smooth systems. The effectiveness of the analytical GMRA is also verified by numerical simulations.