bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reply to “Comment on ‘Two Foreshock Sequences Post Gulia and Wiemer (2019)’ by Kelian Dascher-Cousineau, Thorne Lay, and Emily E. Brodsky” by Laura Gulia and Stefan Wiemer
Authors: Dascher-Cousineau Kelian , Lay Thorne , Brodsky Emily E. 
Published: July 2021

AbstractGulia and Wiemer (2019; hereafter, GW2019) proposed a near-real-time monitoring system to discriminate between foreshocks and aftershocks. Our analysis (Dascher-Cousineau et al., 2020; hereinater, DC2020) tested the sensitivity of the proposed Foreshock Traffic-Light System output to parameter choices left to expert judgment for the 2019 Ridgecrest Mw 7.1 and 2020 Puerto Rico Mw 6.4 earthquake sequences. In the accompanying comment, Gulia and Wiemer (2021) suggest that at least six different methodological deviations lead to different pseudoprospective warning levels, particularly for the Ridgecrest aftershock sequence which they had separately evaluated. Here, we show that for four of the six claimed deviations, we conformed to the criteria outlined in GW2019. Two true deviations from the defined procedure are clarified and justified here. We conclude as we did originally, by emphasizing the influence of expert judgment on the outcome in the analysis.
A Composite Catalog of Damaging Earthquakes for Mainland China
Authors: Li Yilong , Zhang Zhenguo , Xin Danhua 
Published: July 2021

Abstract
We have developed a Mainland China Composite Damaging Earthquake Catalog (MCCDE-CAT), which contains seismic source and socioeconomic damage information, population exposure, and seismic intensity maps of earthquakes that occurred from 1950 to 2018. The completeness and consistency of the data in past damaging earthquake catalogs are crucial to better understanding the damage to our social and economic system from future earthquakes. Although many disaster databases are currently available worldwide, they show a serious lack of data and no consistency. To develop the MCCDE-CAT, we cross-checked and integrated earthquake damage information based on six kinds of earthquake catalogs for Mainland China. Missing information in these catalogs was supplied from records in journal publications and reports published by the government and relevant institutions. We also performed a statistical analysis of the data in the MCCDE-CAT and preliminarily discuss the temporal and spatial characteristics of earthquake disasters and socioeconomic losses in Mainland China. The MCCDE-CAT will contribute to loss estimation for damaging earthquakes, earthquake-related product pricing in the reinsurance industry, and other related fields. More importantly, the MCCDE-CAT will be publicly accessible and provide a basis for researchers to pursue other earthquake disaster-related studies.
Pengelolaan dan Analisis Nilai Tambah By-Products Industri Gula (Studi Kasus di Pabrik Gula Gempolkrep, Mojokerto, Jawa Timur)
Authors: Novianti Relita , Syaukat Yusman , Ekayani Meti 
Published: July 2021

The sugar industry is one of the agriculture-based industries which use sugar cane as a raw material to produce sugar. The processing of sugar cane into sugar generates by-products such as bagasse, molasses, and filter cake which will cause environmental pollution if they are untreated. This research identified the utilization pattern of sugar industry by-products in Gempolkrep Sugar Factory and analyzed the added value from by-products utilization using Hayami Method. Based on the utilization pattern at Gempolkrep Sugar Factory, bagasse is used as an alternative raw material for electricity generation. Filter cake is used as raw material for compost fertilizer. Molasses is used as a raw material for bioethanol manufacture. The added value obtained from processing filter cake into compost is IDR141.335 per ton, while bioethanol products from molasses provide an added value of IDR752.645 per ton. Keywords: bagasse, bioethanol, filter cake, Hayami method, molasses, value added
​​Indian Agricultural Sector Present and Post Pandemic Condition
Authors: Upendra R.S. , Ahmed Mohammed Riyaz , Kumar T. Nitesh , Prithviraj S.R. , Khan A. Shahid 
Published: July 2021

The COVID-19 influenced global pandemic severely affected the market of small industries and had a deep impact on the agri economic of the farmer community across the globe. The main objective of this article is to emphasize on the influence of global pandemic with agriculture and food sector. The lockdown made ambivalent in agriculture, the point of concern is that, at the first phase of lockdown in India, Rabi crops are at harvest stage, due to the lockdown the breakdown of supply chain has been interrupted and left a noticeable impact on the marketability of agriculture crops even though it has registered moderate growth in terms of yield. At present globally mankind is experiencing the waves of pandemic and it caused significant loss to the yield of crops. If the situation continuous, the world is going to experience the hunger deaths. To overcome the issue discussed, agriculture sector needs to adapt new technologies, right from the cultivation, harvest and supply chain with marketing to bring the new normal life back to mankind. This is the right time to have transition from conventional agri practices to the technology invented smart agriculture. Indian agriculture sector should adapt and the former community need to be educated in applying ICT based smart agriculture practices such as utilization of automated machinery, AI (artificial intelligence) enabled cultivation methods, Internet of Things (IoT) and Wireless Sensor Networks based monitoring and maintenance of the agriculture practice. The application ICTs methods in agriculture practices facilitate to choose good quality seeds, optimum quantity of manures required for the enhanced crop yield, and direct monetary of the agriculture firm in order to show resilience to the global pandemic impact on agriculture sector. In the present review authors emphasised on various smart agriculture methods and their importance in promoting the agriculture practice as profitable venture and also how this ICT methods helps the sector to overcome the impact of global pandemic and to bring back the new normal life.
FEASIBILITY AND ISSUES OF RURAL TOURISM BASED ON INTER-INDUSTRY COOPERATION
Authors: Sakurai Seiichi , Teraoka Shingo 
Published: July 2021

The study described herein was conducted to identify general aspects of rural tourism based on the Inter-Industrial Cooperation Project in Japan and to investigate factors and background obstacles to sustainable development of rural tourism management through collaborative organization of various actors. Most approved projects are engaged in producing and marketing local specialty goods. The numerous projects aiming at initiating tourism activities are extremely small. Some approved projects targeting tourism management have already been abandoned. The authors conducted interview surveys to elucidate some typical cases, which elicited the following points about hindrances to sustainable development of rural tourism management based on the Inter-Industrial Cooperation Project: difficulty of maintaining collaborative networks among actors of various types; unexpected tourism-related risks; vulnerability to demands of tourism industry; and the mismatch between the system of national projects and needs for the practice of tourism activities. Results of two case studies underscored these obstacles. The authors finally described the role played by actors outside the rural village and local government officers for improving future collaboration projects.
PEMBERDAYAAN WIRAUSAHA MELALUI DIGITAL MARKETING MASYARAKAT DESA MENANG RAYA KECAMATAN PEDAMARAN KABUPATEN OGAN KOMERING ILIR SUMATERA SELATAN
Authors: Handoko Adi Inggit , Andarini Rindang Senja , Bafadhal Oemar Madri 
Published: July 2021

<p>Desa adalah sebuah perwujudan geografis (wilayah) yang ditimbulkan oleh unsur-unsur geografis sosial, ekonomi, politik, dan kultural dalam hubungan dan pengaruh timbal baliknya dengan daerah-daerah lain disekitarnya. Sebagai wujud pengakuan Negara terhadap Desa, khususnya dalam rangka memperjelas fungsi dan kewenangan desa, serta memperkuat kedudukan desa dan masyarakat desa sebagai subyek pembangunan, diperlukan kebijakan penataan dan pengaturan mengenai desa yang diwujudkan dengan lahirnya UU Nomor 6 Tahun 2014 Tentang Desa. Pedamaran memiliki beberapa sumber daya alam yang dapat dimanfaatkan warga. Disana terdapat lebak lebung atau danau yang dapat dimanfaatkan warga untuk mencari ikan, mengambil tanaman <em>purun</em> untuk dimanfaatkan sebagai berbagai macam kerajinan tangan dan menggembalakan kerbau rawa. Hasil dari kegiatan ini adalah melalui program kerja utama, masyarakat Desa Menang Raya sadar akan besarnya andil pemasaran <em>online </em>(<em>digital marketing</em>) dalam memasarkan produk unggulan desa berupa kerajinan purun dan kemplang. Kesadaran ini didukung dengan pelatihan pembuatan akun <em>e-commerce</em> dan juga pengambilan foto produk agar menarik perhatian pembeli, sehingga masyarakat khususnya pengrajin purun dan pembuat kemplang siap untuk merintis bisnis <em>online</em>-nya.</p><p> </p><p>Kata Kunci: <strong>KKN, Pedamaran, <em>Purun, e-Commerce</em></strong></p>
Symptomatic Nonunion After a Tibial-Sided Posterior Cruciate Ligament Avulsion Fracture Treated with Open Repair
Authors: Johnson Jordan , Gupton Marco , Schneider Jonathan , Deivaraju Chenthuran 
Published: July 2021

Case:
A 30-year-old man was in a motorcycle accident resulting in an avulsion fracture of the tibial insertion of the posterior cruciate ligament (PCL). After 19 months of nonoperative treatment, the patient presented with a nonunion and symptoms of pain and instability. He was treated with an open repair with screw fixation through a posterior approach. Six months postoperatively, the patient returned to his work as a heavy laborer with full range of motion and no instability.

Conclusion:
PCL avulsion fracture nonunion results in symptoms of swelling, pain, and instability. These symptoms can be treated with screw fixation through a posterior approach.
Dissection of an Ulnar Nerve Previously Transposed and Wrapped with Human Amniotic Membrane
Authors: Mirzayan Raffy , Syed Sajjad P. , Shean Christopher J. 
Published: July 2021

Cases:
We present 3 patients who underwent ulnar nerve transposition and wrapping of the nerve with human amniotic membrane (HAM). All 3 patients subsequently required a reoperation for the original pathologic condition (not for ulnar nerve symptoms), necessitating the exploration and dissection of the transposed ulnar nerve. We demonstrate the lack of scar formation and ease of separation between nerve and surrounding tissue, as well as histology in one case taken from the perineural tissues (previous amniotic membrane), demonstrating no inflammatory cells or absence of scar tissue formation.

Conclusion:
Exploration and dissection of a previously transposed ulnar nerve can be facilitated by wrapping the nerve with HAM to prevent scarring and perineural fibrosis.
Internal Rotation Stress Test Reduces Cross-Pinning and Improves Outcomes in Displaced Pediatric Supracondylar Humeral Fractures
Authors: Rees Andrew B. , Schultz Jacob D. , Wollenman Lucas C. , Moore-Lotridge Stephanie N. , Martus Jeffrey E. , Mencio Gregory A. , Schoenecker Jonathan G. 
Published: July 2021

Background:
Stabilization of the medial column is vital in preventing the loss of fixation and malunion in displaced pediatric supracondylar humeral fractures (SCHFs). The preferred percutaneous pin configuration for medial column fixation remains controversial between medial pinning (cross-pinning) and additional lateral-based pinning. The intraoperative internal rotation stress test (IRST) has been proposed to reliably determine the optimal fixation strategy for each unique fracture. This study evaluated the impact of implementing the IRST on both the choice of pin configuration and institution-wide complications in pediatric patients treated operatively for SCHFs.

Methods:
Pediatric patients undergoing percutaneous pinning for SCHFs between 2007 and 2017 at a single center were retrospectively reviewed. The IRST was made a universal institutional practice in 2013. Patients were divided into 2 groups for analysis: (1) patients who underwent treatment before the IRST was implemented in 2013 (the pre-IRST group), and (2) patients who were treated after the IRST was implemented in 2013 (the IRST group). Subgroup analysis was completed for patients in the IRST group who were treated with cross-pinning or 3 lateral-based pins.

Results:
In this study, 820 patients in the pre-IRST group and 636 patients in the IRST group were included. After the IRST implementation, the rate of loss of fixation fell from 1.2% to 0% (p = 0.003), and the reoperation rate fell from 3.3% to 0.2% (p < 0.001). No cases resulted in a loss of fixation after the adoption of the IRST. The number of patients treated with cross-pinning decreased significantly from 53.2% to 31.6% (p < 0.001) after the IRST implementation, yet cross-pinning continued to be used for more severe fractures. Complication rates within the IRST group were not significantly different (p > 0.05) between cross-pinning and 3 lateral-based pins.

Conclusions:
In the largest cohort reported on to date, to our knowledge, institutional implementation of the IRST resulted in a significant reduction in the use of cross-pinning. Although the usage of cross-pinning decreased, cross-pinning was still used frequently in the most severe fractures. The IRST use also resulted in significantly fewer complications such as loss of fixation after institution-wide implementation of the IRST for treating pediatric SCHFs.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
The Factors Affecting the Physical Activity of the Health Care Workers of Iran University of Medical Sciences: A Qualitative Study
Authors: Hoveidamanesh Soodabeh , Tayefi Batool , Rampisheh Zahra , Khalili Narjes , Ramezani Mozhdeh 
Published: July 2021

Abstract
Background: The low physical activity is a challenge in adults. A majority of adults spend many hours each week at work, so the workplace is a suitable site for health promotion and implementation of physical activity programs. This qualitative study was implemented to identify worksite physical activity barriers and facilitators from the perspective of the employees of the Iran University of Medical Science. Methods: In the present qualitative content analysis, five focus group discussions were held with the participation of 68 personnel of Iran University of Medical Sciences. Purposive sampling with maximum diversity was carried out for the study. Results: The analysis of the data led to the identification of three general themes, including challenges and barriers, strategies, and incentives (facilitators). The four main categories of challenges and barriers included policy-making and legislation, organizational factors, structural factors, and personal factors. Most barriers identified by the participants were placed in the personal factors and organizational factors categories. The strategies for increasing physical activity were identified in the following three categories: Policy-making and legislation, organizational factors, and environmental factors. The majority of the strategies proposed were placed in the organizational factors and policy-making and legislation categories.Conclusions: Increasing physical activity in the workplace as a strategy for the general promotion of physical activity in people requires interventions in different areas, especially with regard to organizational factors and policy-making and legislation.
SOX2 knockdown with siRNA reverses cisplatin resistance in NSCLC by regulating APE1 signaling
Authors: Chen Taiyu , Zhou Ji , Li Peng-cheng , Tang Chun-han , Yang Fang , Xu Ke , Li Tao , Ren Tao 
Published: July 2021

Abstract
Objective
SOX2 is related to drug resistance in many types of cancer, including lung cancer. Herein, we investigated the role of SOX2 and its regulatory signaling in cisplatin-treated non-small-cell lung cancer (NSCLC).
Methods
The effects of SOX2 on cell viability, proliferation, and apoptosis were evaluated in vitro. Western blotting, real-time quantitative PCR (qPCR), immunohistochemistry (IHC), and luciferase reporter assays were used to investigate the underlying mechanism. Kaplan-Meier survival analysis and the log-rank test were used to assess the relationship between SOX2 expression and patient survival.
Results
A549/CDDP cells had marked resistance to cisplatin and stronger colony formation ability than A549 cells. The expression of SOX2 protein or mRNA in A549/CDDP was higher than that in A549. Knockdown of SOX2 in A549/CDDP induced apoptosis by inhibiting colony formation and decreasing viability, but overexpression of SOX2 reversed these effects. Interestingly, Genomatix software predicted that the APE1 promoter has some SOX2 binding sites, while the SOX2 promoter has no APE1 binding sites. Furthermore, luciferase reporter assays proved that SOX2 could bind the promoter of APE1 in 293T cells. We further verified that SOX2 expression was not affected by shAPE1 in A549/CDDP. As expected, colony formation was obviously inhibited and apoptosis was strongly enhanced in A549/CDDP treated with SOX2 siSOX2 alone or combined with CDDP compared with control cells. Meaningfully, patients with high expression of SOX2 survived longer than those with low expression of SOX2.
Conclusion
siSOX2 overcomes cisplatin resistance by regulating APE1 signaling, providing a new target for overcoming cisplatin resistance in NSCLC.
Effects of the Covid-19 Pandemic on Maternity Staff in 2020 – A Scoping Review
Authors: Schmitt Nadine , Mattern Elke , Cignacco Eva , Seliger Gregor , König-Bachmann Martina , Striebich Sabine , Ayerle Gertrud M. 
Published: July 2021

Abstract
In the spring of 2020, the SARS-CoV-2 virus caused the Covid-19 pandemic, bringing with it drastic changes and challenges for health systems and medical staff. Among the affected were obstetricians and midwives, whose close physical contact with pregnant women, women who recently gave birth, and their children was indispensable. In the obstetric setting, births cannot be postponed, and maternity staff had to adapt to assure obstetric safety while balancing evidence-based standards with the new challenges posed by the pandemic. This scoping review gives a comprehensive overview of the effecs the Covid-19 pandemic had on maternity staff. We followed the evidence-based approach described by Arksey & O’Malley: we searched several databases for English and German articles published between January 2020 and January 2021 that discussed or touched upon the effects the pandemic had on maternity staff in OECD countries and China.We found that structural challenges caused by the crisis and its subjective effects on maternity staff fell into two main topic areas. Structural challenges (the first main topic) were divided into five subtopics: staff shortages and restructuring; personal protective equipment and tests; switching to virtual communication; handling women with a positive SARS-CoV-2 infection; and excluding accompanying persons. The pandemic also strongly affected the staff’s mental health (the second main topic.) Attempting to meet challenges posed by the pandemic while afraid of contamination, suffering overwork and exhaustion, and struggling to resolve ethical-moral dilemmas had severe negative subjective effects. Several studies indicated increased depression, anxiety, stress levels, and risk of post-traumatic stress symptoms, although the crisis also generated strong occupational solidarity.Care for pregnant, birthing, and breast-feeding women cannot be interrupted, even during a pandemic crisis that requires social distancing. Maternity staff sometimes had to abandon normal standards of obstetric care and were confronted with enormous challenges and structural adjustments that did not leave them unscathed: their mental health suffered considerably. Researchers should study maternity staff’s experiences during the pandemic to prepare recommendations that will protect staff during future epidemics.
MMTV Prevalence in Breast Cancer Samples in Romania - Do Major Geographical Differences Exist in The World Population?
Authors: Fekete Zsolt , Terțan Bristena Octavia , Ráduly Lajos , Eniu Dan Tudor , Buiga Rares , Galatâr Mihaela , Berindan-Neagoe Ioana 
Published: July 2021

Abstract
Background Breast cancer, although the most frequently diagnosed malignant tumor in humans, has a less clear etiology compared to other frequent cancer types. Mouse-mammary tumor virus (MMTV) is involved in breast cancer in mice and dogs and might play a role in the etiology of some breast cancers in humans, since it has been identified in 20-40% of breast cancer samples in Western Europe, USA, Australia and some other parts of the world’s population. The purpose of our study was to identify MMTV DNA sequences in breast tissue samples from breast cancer patients who underwent curative surgery in our regional center in Romania, EU. MethodsWe selected 75 patients with non-metastatic breast cancer treated surgically with curative intent, which did not undergo any neoadjuvant treatment. Out of these patients, 50 underwent radical lumpectomy and 25 modified radical mastectomy. We searched using PCR the MMTV-like DNA env sequence in the breast cancer tissue and normal breast tissue obtained from the same patients. ResultsNone of the examined samples was positive for MMTV-like target sequences on PCR.ConclusionsWe could not prove that MMTV plays a role in the etiology of breast cancer in our patient group. This finding is similar to publications of other geographically related research groups and might be due to the fact that only the Mus musculus domesticus mouse species was proven to carry infectious MMTV, but not the Mus musculus musculus species, which is specific to South-Eastern Europe (including Romania) and some parts of Asia.
Neurological manifestations of COVID-19 associated multisystem inflammatory syndrome in adults (MIS-A)
Authors: Maramattom Boby Varkey 
Published: July 2021

Abstract
Introduction Multi-system inflammatory syndrome (MIS) is a para infectious or post infectious extra-pulmonary complication of COVID-19. Neurological complications are better described in children with Multi-system inflammatory syndrome (MIS) in children (MIS-C). There is a paucity of literature about the neurological manifestations of Multi-system inflammatory syndrome (MIS) in adults (MIS-A).Materials and methods Over a 12-month period, from June 2020 to June 2021, over 350 patients were admitted to our medical and COVID ICUs. Of these, eight patients (2.2%) admitted to our ICU were detected to have a neurologic MIS-A.Results Most patients had a stroke (72.5%). Other manifestations included transverse myelitis, COVID encephalitis, acute encephalopathy, rhabdomyolysis and critical illness myo-neuropathy.Conclusions Most patients with MIS-A and severe neurological involvement had a poor outcome.