bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using RE-AIM to examine the potential public health impact of an integrated collaborative care intervention for weight and depression management in primary care: Results from the RAINBOW trial
Authors: Lewis Megan A. , Wagner Laura K. , Rosas Lisa G. , Lv Nan , Venditti Elizabeth M. , Steinman Lesley E. , Weiner Bryan J. , Goldhaber-Fiebert Jeremy D. , Snowden Mark B. , Ma Jun 
Published: March 2021

BackgroundAn integrated collaborative care intervention was used to treat primary care patients with comorbid obesity and depression in a randomized clinical trial. To increase wider uptake and dissemination, information is needed on translational potential.MethodsThe trial collected longitudinal, qualitative data at baseline, 6 months (end of intensive treatment), 12 months (end of maintenance treatment), and 24 months (end of follow-up). Semi-structured interviews (n = 142) were conducted with 54 out of 409 randomly selected trial participants and 37 other stakeholders, such as recruitment staff, intervention staff, and clinicians. Using a Framework Analysis approach, we examined themes across time and stakeholder groups according to the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework.ResultsAt baseline, participants and other stakeholders reported being skeptical of the collaborative care approach related to some RE-AIM dimensions. However, over time they indicated greater confidence regarding the potential for future public health impact. They also provided information on barriers and actionable information to enhance program reach, effectiveness, adoption, implementation, and maintenance.ConclusionsRE-AIM provided a useful framework for understanding how to increase the impact of a collaborative and integrative approach for treating comorbid obesity and depression. It also demonstrates the utility of using the framework as a planning tool early in the evidence-generation pipeline.
Minimally invasive versus open radical resection surgery for hilar cholangiocarcinoma: Comparable outcomes associated with advantages of minimal invasiveness
Authors: Tang Wei , Qiu Jian-Guo , Deng Xin , Liu Shan-Shan , Cheng Luo , Liu Jia-Rui , Du Cheng-You 
Published: March 2021

Background
Minimally invasive surgery (MIS) provides a new approach for patients with hilar cholangiocarcinoma (HCCA). However, whether it can achieve similar outcomes to traditional open surgery (OS) remains controversial.

Methods
To assess the safety and feasibility of MIS for HCCA, a systematic review and meta-analysis was performed to compare the outcomes of MIS with OS. Seventeen outcomes were assessed.

Results
Nine studies involving 382 patients were included. MIS was comparable in blood transfusion rate, R0 resection rate, lymph nodes received, overall morbidity, severe morbidity (Clavien–Dindo classification > = 3), bile leakage rate, wound infection rate, intra-abdominal infection rate, days until oral feeding, 1-year overall survival, 2-year overall survival and postoperative mortality with OS. Although operation time was longer (mean difference (MD) = 93.51, 95% confidence interval (CI) = 64.10 to 122.91, P < 0.00001) and hospital cost (MD = 0.68, 95% CI = 0.03 to 1.33, P = 0.04) was higher in MIS, MIS was associated with advantages of minimal invasiveness, that was less blood loss (MD = -81.85, 95% CI = -92.09 to -71.62, P < 0.00001), less postoperative pain (MD = -1.21, 95% CI = -1.63 to -0.79, P < 0.00001), and shorter hospital stay (MD = -4.22, 95% CI = -5.65 to -2.80, P < 0.00001).

Conclusions
The safety and feasibility of MIS for HCCA is acceptable in selected patients. MIS is a remarkable alternative to OS for providing comparable outcomes associated with a benefit of minimal invasiveness and its application should be considered more.
Zavattini: Il Neo-Realismo e il Nuovo Cinema Latino-americano Volumi I–II, David Brancaleone (2019)
Authors: Valecce Anastasia 
Published: March 2021

Review of: Zavattini: Il Neo-Realismo e il Nuovo Cinema Latino-americano Volumi I–II, David Brancaleone (2019)
Vol. I, Parma: Diabasis, 486 pp.,
ISBN 978-8-88103-935-7, p/bk, €24.00
Vol. II, Parma: Diabasis 794 pp.,
ISBN 978-8-88103-937-1, e-book, free
Indro Montanelli e il cinema: Un contadino toscano candidato all’Oscar, Rinaldo Vignati (2019)
Authors: Leavitt Charles L. 
Published: March 2021

Review of: Indro Montanelli e il cinema: Un contadino toscano candidato all’Oscar, Rinaldo Vignati (2019)
Milan and Udine: Mimesis Edizioni, 264 pp.,
ISBN 978-8-85755-616-1, p/bk, €22.00
Accessory Splenic Artery Causing Massive Gastrointestinal Bleed
Authors: Patel Priyesh , Chadalavada Pravallika , Singh Amandeep , Gurajala Ram Kishore , Achkar Jean-Paul 
Published: March 2021

ABSTRACT
The presentation of an upper gastrointestinal bleed secondary to an accessory splenic artery is a rare circumstance described only in 2 previous case reports. This report is the first to describe an upper gastrointestinal bleed consequent of a submucosal accessory splenic artery arising from the left phrenic artery, requiring multiple endoscopies and endovascular embolization. Vascular anatomic variants can pose a challenge to treatment, especially when they are unknown. This case adds to the limited number of case reports involving accessory splenic arteries.
The Realization of West Germanic+[sk] in Low German
Authors: Hall Tracy Alan 
Published: March 2021

AbstractThe present study investigates the multiple reflexes of historical +[sk] clusters in Low German (Westphalian/Northern Low German) dialects. Original descriptions of over thirty varieties of those dialects spoken between the end of the 19thcentury to the present day reveal that there are a number of realizations of [sk] (e. g. [sk], [sx], [sç], [ʃx], [ʃç], [s]), whose occurrence depends on both the position within a word (initial, medial, final) and geography (the location of the dialect within a broad region in northwest Germany). The synchronic patterns are argued to reflect a series of diachronic stages: The change from any one of those stages to the next is shown to involve either the emergence of a new sound change (rule addition) or the extension of a preexisting change to a new context (rule generalization). A secondary goal of the present contribution is to show how the treatment of Low German sheds light on the change from historical +[sk] to [ʃ] in High German. In particular, it is argued – contrary to the position taken by the overwhelming majority of Germanicists – that the High German change involved the coalescence of two sounds into one without any intermediate stages.
Der deutsche Dativ genealogisch und diachron
Authors: Kotin Michail L. 
Published: March 2021

AbstractThe German dative case from genealogic and diachronic perspective. A language-change study about the third case. The dative case belongs to the so-called syncretistic cases, i. e., it encodes multiple functions inherited from the Indo-European cases locative, instrumental, ablative and dative. The paper aims to show the emergence of diverse case functions formally encoded by the dative case from a common base which is assumed to have the locative semantics. The decisive point was, according to the hypothesis, the development of the directional function towards the object or away from it. The addressee dative arose as a result of a specific reanalysis of movement semantics. The so-called dative of subject emerged from reanalysis of the subject-related experiencer function.
Design, synthesis, and biological activities of novel thiophene, pyrimidine, pyrazole, pyridine, coumarin and isoxazole: Dydrogesterone derivatives as antitumor agents
Authors: El-Sharkawy Karam A. , Al Bratty Mohammed , Alhazmi Hassan A. , Najmi Asim 
Published: March 2021

Abstract
On the basis of our consideration to design and to develop antitumor activities of heterocyclic compound derivatives, especially in fused ring system, we refer to the possibility of the heterocyclic extension of one of the most important steroid compounds used as a medicinal drug. The reaction of dydrogesterone with each of the malononitrile or ethylcyanoacetate containing elemental sulfur afforded thiophene derivatives 1a,b. Also, dydrogesterone was reacted with a mixture of ethylcyanoacetate–hydrazine, ethylcyanoacetae–urea, or ethylcyanoacetate–thiourea to produce pyrazole derivative 4 and pyrimidine derivatives 5a,b. Thienopyrimidine derivatives 2a–d were introduced from the reaction of thiophene derivatives 1a,b with either phenylisothiocyanate or benzoylisothioyanate. Furthermore, compounds 1a,b were directed toward the reaction with ethylcyanoacetate to produce compounds 6a,b, and the last compounds 6a,b were directed toward cyclization to obtain thienopyridine derivatives 7a,b. In addition, compounds 6a,b were subjected to react with different carbonyl compounds, such as salicylaldehyde, cyclopentanone-elemental sulfur, malonaldehyde, and acetylacetone to produce coumarin derivatives 8a,b, fused thiophene derivatives 9a,b, and pyridine derivatives 10a–d. Isooxazole derivatives 12a,b were afforded through the reaction of compounds 6a,b with hydroxylamine hydrochloride. Finally, 2-pyridone derivatives 14a,b were obtained through the reaction of compounds 6a,b with benzoylacetonitrile. Conformation structure of the synthesized compounds was established by applying IR, 1H NMR, 13C NMR, and mass spectrometry, and their antitumor activity was examined. Some compounds showed promising growth inhibitory effects on the three different cell lines.
A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity
Authors: Sever Belgin , Altıntop Mehlika Dilek , Demir Yeliz , Türkeş Cüneyt , Özbaş Kaan , Çiftçi Gülşen Akalın , Beydemir Şükrü , Özdemir Ahmet 
Published: March 2021

Abstract
In an effort to identify potent aldose reductase (AR) inhibitors, 5-(arylidene)thiazolidine-2,4-diones (1–8), which were prepared by the solvent-free reaction of 2,4-thiazolidinedione with aromatic aldehydes in the presence of urea, were examined for their in vitro AR inhibitory activities and cytotoxicity. 5-(2-Hydroxy-3-methylbenzylidene)thiazolidine-2,4-dione (3) was the most potent AR inhibitor in this series, exerting uncompetitive inhibition with a K
i value of 0.445 ± 0.013 µM. The IC50 value of compound 3 for L929 mouse fibroblast cells was determined as 8.9 ± 0.66 µM, pointing out its safety as an AR inhibitor. Molecular docking studies suggested that compound 3 exhibited good affinity to the binding site of AR (PDB ID: 4JIR). Based upon in silico absorption, distribution, metabolism, and excretion data, the compound is predicted to have favorable pharmacokinetic features. Taking into account the in silico and in vitro data, compound 3 stands out as a potential orally bioavailable AR inhibitor for the management of diabetic complications as well as nondiabetic diseases.
Towards the Modelling of Veillance based Citizen Profiling using Knowledge Graphs
Authors: Munir Siraj , Jami Syed Imran , Wasi Shaukat 
Published: March 2021

Abstract
In this work we have proposed a model for Citizen Profiling. It uses veillance (Surveillance and Sousveillance) for data acquisition. For representation of Citizen Profile Temporal Knowledge Graph has been used through which we can answer semantic queries. Previously, most of the work lacks representation of Citizen Profile and have used surveillance for data acquisition. Our contribution is towards enriching the data acquisition process by adding sousveillance mechanism and facilitating semantic queries through representation of Citizen Profiles using Temporal Knowledge Graphs. Our proposed solution is storage efficient as we have only stored data logs for Citizen Profiling instead of storing images, audio, and video for profiling purposes. Our proposed system can be extended to Smart City, Smart Traffic Management, Workplace profiling etc. Agent based mechanism can be used for data acquisition where each Citizen has its own agent. Another improvement can be to incorporate a decentralized version of database for maintaining Citizen profile.
Route optimization for city cleaning vehicle
Authors: Wojciechowski Łukasz , Cisowski Tadeusz , Małek Arkadiusz 
Published: March 2021

AbstractThe basic problem concerning the waste management system is work organization, which should be effective with maximum profit and minimum financial outlays. This means that the key factor for the efficient functioning of this system are all types of costs. When collecting waste, the main operational cost factors are the driver's working time and the service time of the waste collection vehicle, as well as the route that the vehicle has to cover. The article presents route optimization solution for a vehicle collecting urban waste (both mixed and segregated) is a simple method of determining the order of driving through individual city streets. The prepared solution is universal and is not limited only to the surveyed housing estate. It presents a pattern that can be applied to other routes in a similar way. Shortening the distance and thus the working time is a result of minimizing empty runs and moving several times over the same section. Developing an optimal route for so many values requires very complicated calculations and would not reflect the real possibilities of waste collection by employees and MZGK Company. The presented solution can be used as an instruction to take the first steps to optimize the operation of the vehicle and as an initial point for further modifications of the operating system.
Southernizing and decolonizing the Sociology of Language: African scholarship matters
Authors: Rudwick Stephanie , Makoni Sinfree 
Published: March 2021

Abstract
In this short article we call for decolonization strategies in the Sociology of Language through a focus shift towards the global South, in particular Africa and a heightened attention to “race” as a significant category. We highlight three primary points that require critical attention in a decolonized Sociology of Language: (i) the identification of northern sociolinguistic theories which have been masked as universal and a critical shift towards theoretical frameworks emerging from the South; (ii) the acknowledgement of “white” privilege and “white fragility” in language studies and its related problem of ignoring “race” as a significant category, in scholarship as well as among authors/editors; and (iii) the under-representation of (especially female) scholars of colour in sociolinguistic research.
Powered by assemblage: language for multiplicity
Authors: Pietikäinen Sari 
Published: March 2021

Abstract
Assemblage is one way to examine complexities in today’s world. In Deleuzian thinking, assemblage refers to both the act of assembling diverse elements and the arrangements of these elements for a specific purpose. Importantly, it is the interaction between elements that allows the assemblage to become more than the sum of its parts. Applying this concept to long-term research on Cold Rush – the transformation of the Arctic commons into commodities – I argue that examining the boom, bust, and buzz around the commons can be fruitfully conceptualised and studied with assemblage. This approach brings with it an ontological shift from binaries into multiplicities and multiple temporalities. Assemblage also sheds light on the role of discourse in these transformations and shows how language gains its productive force only in collaboration with other elements.
Redrawing the boundary of “speech community”: how and why the historicity and materiality of language and the space/place distinction matter to its reconceptualization
Authors: Inoue Miyako 
Published: March 2021

Abstract
This essay contemplates how we adapt existing sociolinguistic theoretical concepts, methodologies, and analytical units to the world we live in today. Regardless of one’s location on the globe, our lives are profoundly affected by increasingly intense global interconnections and, at the same time, equally intense differentiation of space attending late global capitalism and the evolving nation-state system. While sociolinguistics has attended the heterogeneity within the speech community, in the world today as such, the idea of speech community as bounded is no longer tenable. In envisioning the future direction of IJSL and its leadership in the field, this essay suggests that speech community as an analytical concept would be significantly advanced through the theoretical integration of the space/place distinction and the historicity and materiality of language into its architectonics. By drawing on some of the recent works for guiding models, the essay argues that the reconceptualization of speech community would also demand radical openness to interdisciplinary approaches.
Characterization of cardiac autonomic function in COVID-19 using heart rate variability: a hospital based preliminary observational study
Authors: Kaliyaperumal Deepalakshmi , RK Karthikeyan , Alagesan Murali , Ramalingam Sudha 
Published: March 2021

Abstract

Objectives
The novel corona virus disease, which was initially reported in China in late 2019, has become a global pandemic affecting 330 million cases. COVID-19 affects predominantly the respiratory system, in addition to other organ systems, mainly the cardiovascular system. One of the hypotheses is that virus entering the target cells by binding to angiotensin converting enzyme 2 affecting hypothalamic pituitary axis could lead to dysautonomia which is measured by heart rate variability (HRV). HRV is a non-invasive measure of autonomic function that facilitates identification of COVID-19 patients at the risk of developing cardiovascular complications. So, we aimed to assess HRV in COVID patients and compare between COVID patients and normal controls.

Methods
In a case control design, we compared 63 COVID-19 infected patients with 43 healthy controls matched for age and gender. Along with clinical characterization, heart rate variability was evaluated using ambulatory 5 min ECG in lead II and expressed in frequency and time domain measures. Statistical analysis was performed using SPSS 17.0.

Results
Mean age of the study population was 49.1 ± 14.2 years and 71 (66.9%) were males. Frequency domain measures high (HF) and low (LF) frequency powers were significantly decreased in COVID-19 patients compared to controls. HF/LF and LF/HF ratios were not different between groups. Time domain measures rMSSD (root mean square of successive RR interval differences) and SDNN (standard deviation of NN intervals) were significantly increased among COVID-19 subjects. COVID-19 infection was associated with increased parasympathetic activity as defined by rMSSD>40 {adjusted odds ratio 7.609 (95% CI 1.61–35.94); p=0.01} and SDNN>60 {adjusted odds ratio 2.620 (95% CI 1.070–6.44); p=0.035} after adjusting for age, gender and comorbidities.

Conclusions
Our study results showed increased parasympathetic tone in COVID patients. Early diagnosis of autonomic imbalance in COVID patients is needed to plan management and limit progression of disease.
Metal nanoparticles-based nanoplatforms for colorimetric sensing: A review
Authors: Xu Ning , Jin Shuang , Wang Li 
Published: March 2021

Abstract
With the progress of analysis technology and nanotechnology, colorimetric detection has become one of the research hotspots in the field of analytical chemistry. Compared with traditional detection methods, the colorimetric method has many advantages, such as high sensitivity, good selectivity, convenience and fast, as well as low cost. In recent years, metal nanoparticles have been introduced into colorimetry, making the research and application of colorimetry develop rapidly. In this work, we summarize the usual colorimetric detection methods based on metal nanoparticles-based nanozymes and their applications in the last five years. We hope that this work will help readers understand the mechanism and practical application value of nanozyme-based colorimetric biosensors. Meanwhile, this work may give some hints and references for future colorimetric detection research to promote the application and development of nanozyme-based colorimetry in biomedical and environmental analysis.
Changes in cell membranes of white blood cells treated with a common food additive E407a
Authors: Tkachenko Anton , Onishchenko Anatolii , Posokhov Yevgen , Roshal Alexander , Myasoedov Valeriy , Nakonechna Oksana 
Published: March 2021

Abstract

Objectives
To estimate the state of phospholipid bilayer of rats WBCs exposed to a common food additive E407a, which is used as a thickener and emulsifier, during 4 h using a fluorescent probe − ortho-hydroxy derivative of 2,5-diaryl-1,3-oxazole.

Materials and methods
Steady-state fluorescence spectroscopy: a study by the environment-sensitive fluores-cent probe − 2-(2′-hydroxy-phenyl)-5-phenyl-1,3-oxazole (probe O1O).

Results
Changes are detected in the spectra of the fluorescent probe bound to rat WBCs treated with the solutions of E407a of various concentrations in comparison with the corresponding spectra of the probe incubated with the untreated leukocytes. The decrease in polarity and proton-donor ability is observed in the lipid membranes of leukocytes in the region, where the probe locates.

Conclusions
Our findings suggest a higher dehydration of leukocyte membranes of rats treated with a common food additive E407a at high concentrations and, thus, indicate that exposure to high doses of E407a leads to the increase in the lipid order (i.e. to decrease in fluidity) of the membranes of rat WBCs.
Development and usability testing of an educational mobile learning app for climate change and health impacts
Authors: Aydoğan Elif , Atik Ali Derya , Dikmen Ergin Şafak , Erkoç Figen 
Published: March 2021

Abstract

Objectives
Mobile applications, social media platforms are changing Internet user behavior; creating a new era of education in a connected world. We have previously reported training needs of health providers in the Climate Change. Aim is to develop and test an Android® mobile app as an effective smart learning environment for climate change health impacts.

Methods
The quasi-experimental design method was used in five phases: easy-to-reach, rich content Mobile app design and development for Android® operating system, scale development, finalizing scales to be used, implementation, data collection, analysis. Dependent t-test of pre-test and post-test awareness scores was analyzed. Usability and satisfaction were assessed with two scales; quantitative data with descriptive statistics.

Results
The developed Mobile app was effective in enhancing students’ learning experience, and well-received in terms of adopting and using such technology for educational purposes. Pre-test and post-test scores different statistically (p<0.05); increasing participants’ awareness level and were satisfied.

Conclusions
We conclude that our Mobile app, m-learning project, is successfully incorporated into the learning context; when tested, raised awareness about climate change and health effects for the public. To our knowledge, no currently existing tool to provide new mobile application for climate change education and promote awareness exists.