bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptions of Ghanaian traditional health practitioners, primary health care workers, service users and caregivers regarding collaboration for mental health care
Authors: Nyame Solomon , Adiibokah Edward , Mohammed Yasmin , Doku Victor C. , Othieno Caleb , Harris Benjamin , Gureje Oye , Soraya Seedat , Appiah-Poku John 
Published: April 2021

AbstractBackgroundIn low- and middle-income countries, the paucity of conventional health services means that many people with mental health problems rely on traditional health practitioners (THPs). This paper examines the possibility of forging partnerships at the Primary Health Care (PHC) level in two geopolitical regions of Ghana, to maximize the benefits to both health systems.MethodsThe study was a qualitative cross-sectional survey. Eight (8) focus group discussions (FGDs) were conducted between February and April 2014. The views of THPs, PHC providers, service users (i.e. patients) and their caregivers, on the perceived benefits, barriers and facilitators of forging partnerships were examined. A thematic framework approach was employed for analysis.ResultsThe study revealed that underlying the widespread approval of forging partnerships, there were mutual undertones of suspicion. While PHC providers were mainly concerned that THPs may incur harms to service users (e.g., through delays in care pathways and human rights abuses), service users and their caregivers highlighted the failure of conventional medical care to meet their healthcare needs. There are practical challenges to these collaborations, including the lack of options to adequately deal with human rights issues such as some patients being chained and exposed to the vagaries of the weather at THPs. There is also the issue of the frequent shortage of psychotropic medication at PHCs.ConclusionAddressing these barriers could enhance partnerships. There is also a need to educate all providers, which should include sessions clarifying the potential value of such partnerships.
Electronic patient record and its effects on social aspects of interprofessional collaboration and clinical workflows in hospitals (eCoCo): a mixed methods study protocol
Authors: Beckmann Marina , Dittmer Kerstin , Jaschke Julia , Karbach Ute , Köberlein-Neu Juliane , Nocon Maya , Rusniok Carsten , Wurster Florian , Pfaff Holger 
Published: April 2021

AbstractBackgroundThe need for and usage of electronic patient records within hospitals has steadily increased over the last decade for economic reasons as well as the proceeding digitalization. While there are numerous benefits from this system, the potential risks of using electronic patient records for hospitals, patients and healthcare professionals must also be discussed. There is a lack in research, particularly regarding effects on healthcare professionals and their daily work in health services. The studyeCoCoaims to gain insight into changes in interprofessional collaboration and clinical workflows resulting from introducing electronic patient records.MethodseCoCois a multi-center case study integrating mixed methods from qualitative and quantitative social research. The case studies include three hospitals that undergo the process of introducing electronic patient records. Data are collected before and after the introduction of electronic patient records using participant observation, interviews, focus groups, time measurement, patient and employee questionnaires and a questionnaire to measure the level of digitalization. Furthermore, documents (patient records) as well as structural and administrative data are gathered. To analyze the interprofessional collaboration qualitative network analyses, reconstructive-hermeneutic analyses and document analyses are conducted. The workflow analyses, patient and employee assessment analyses and classification within the clinical adoption meta-model are conducted to provide insights into clinical workflows.DiscussionThis study will be the first to investigate the effects of introducing electronic patient records on interprofessional collaboration and clinical workflows from the perspective of healthcare professionals. Thereby, it will consider patients’ safety, legal and ethical concerns and quality of care. The results will help to understand the organization and thereby improve the performance of health services working with electronic patient records.Trial registrationThe study was registered at the German clinical trials register (DRKS00023343, Pre-Results) on November 17, 2020.
The effects of competition and bundled payment on patient reported outcome measures after hip replacement surgery
Authors: Goude Fanny , Kittelsen Sverre A. C. , Malchau Henrik , Mohaddes Maziar , Rehnberg Clas 
Published: April 2021

AbstractBackgroundCompetition-promoting reforms and economic incentives are increasingly being introduced worldwide to improve the performance of healthcare delivery. This study considers such a reform which was initiated in 2009 for elective hip replacement surgery in Stockholm, Sweden. The reform involved patient choice of provider, free establishment of new providers and a bundled payment model. The study aimed to examine its effects on hip replacement surgery quality as captured by patient reported outcome measures (PROMs) of health gain (as indicated by the EQ-5D index and a visual analogue scale (VAS)), pain reduction (VAS) and patient satisfaction (VAS) one and six years after the surgery.MethodsUsing patient-level data collected from multiple national registers, we applied a quasi-experimental research design. Data were collected for elective primary total hip replacements that were carried out between 2008 and 2012, and contain information on patient demography, the surgery and PROMs at baseline and at one- and six-years follow-up. In total, 36,627 observations were included in the analysis. First, entropy balancing was applied in order to reduce differences in observable characteristics between treatment groups. Second, difference-in-difference analyses were conducted to eliminate unobserved time-invariant differences between treatment groups and to estimate the causal treatment effects.ResultsThe entropy balancing was successful in creating balance in all covariates between treatment groups. No significant effects of the reform were found on any of the included PROMs at one- and six-years follow-up. The sensitivity analyses showed that the results were robust.ConclusionsCompetition and bundled payment had no effects on the quality of hip replacement surgery as captured by post-surgery PROMs of health gain, pain reduction and patient satisfaction. The study provides important insights to the limited knowledge on the effects of competition and economic incentives on PROMs.
Antimicrobial resistance and genotyping of Staphylococcus aureus obtained from food animals in Sichuan Province, China
Authors: Gan Ting , Shu Gang , Fu Hualin , Yan Qigui , Zhang Wei , Tang Huaqiao , Yin Lizi , Zhao Ling , Lin Juchun 
Published: April 2021

Abstract
Background
Staphylococcus aureus (S. aureus), especially methicillin-resistant Staphylococcus aureus (MRSA), is considered a common zoonotic pathogen, causing severe infections. The objective of this study was to investigate the antimicrobial susceptibility, resistance genes and molecular epidemiology among MRSA and methicillin-susceptible Staphylococcus aureus (MSSA) isolated from food animals in Sichuan Province, China.

Methods
This study was conducted on 236 S. aureus isolates. All isolates were subjected to antimicrobial susceptibility testing by using a standard microbroth dilution method. The Polymerase Chain Reaction (PCR) was performed to identify genes encoding the β-lactams resistance (blaZ, mecA), macrolides (ermA, ermB, ermC) and aminoglycosides (aacA-aphD). The molecular structures and genomic relatedness of MRSA isolates were determined by staphylococcal chromosome cassette mec (SCCmec) typing and pulsed-field gel electrophoresis (PFGE), respectively.

Results
Among 236 isolates, 24 (10.17 %) were recognized as MRSA. MRSA isolates showed different resistance rates to 11 antimicrobials ranging from 33.33 to 100 %, while for MSSA isolates the rates varied from 8.02 to 91.51 %. Multi-drug resistance phenotype was found in all MRSA isolates. The ermC gene encoding macrolides-lincosamides-streptogramin B was the most prevalent gene detected in 87.29 % of the S. aureus isolates, followed by ermB (83.05 %), blaZ (63.98 %), aacA-aphD (44.07 %), ermA (11.44 %) and mecA (11.02 %) genes. The prevalence of resistance genes in MRSA isolates was significantly higher than that of MSSA. Regarding the molecular morphology, SCCmec III (12/24, 50 %) was the most common SCCmec type. Furthermore, the PFGE typing showed that 24 MRSA were divided into 15 cluster groups (A to O), the major pulsotype J encompassed 25 % of MRSA isolates.

Conclusions
The S. aureus isolates from food animals in Sichuan province of China have severe antimicrobials resistance with various resistance genes, especially MRSA isolates. Additionally, the genetic pool of MRSA isolates is diverse and complex, and further investigation is necessary.
Evaluation of E. coli Nissle1917 derived metabolites in modulating key mediator genes of the TLR signaling pathway
Authors: Damoogh Sheyda , Vosough Mehrad , Hadifar Shima , Rasoli Masoumeh , Gorjipour Ali , Falsafi Sarvenaz , Behrouzi Ava 
Published: April 2021

AbstractObjectiveGut-microbiota plays key roles in many aspects like the health and illness of humans. It's well proved that modification of gut microbiota by probiotics is useful for improving inflammatory bowel disease (IBD) conditions. According to recent studies, different types of bacterial metabolites can affect immune cells and inflammation conditions. The present study aimed to evaluate the anti-inflammatory effects of metabolites ofE. coliNissle1917.ResultsThe cell-free supernatant could modulate TNF-α production and affected many crucial mediators in the Toll-like receptor (TLR) signaling pathway. Also, supernatant showed significant dose-dependent properties in this regard. In this study, the TLR signaling pathway was found among probable mechanisms by which probiotics can affect inflammatory situations. These findings provide additional evidence on the use of probiotic metabolites for inhibiting and down-regulating numerous key mediator factors in the TLR signaling pathway. Aberrant or dysfunctional TLR signaling contributes to the development of acute and chronic intestinal inflammatory pathways in IBD. Therefore, finding a component that can affect this process might be considered for therapeutic targets in IBD patients.
The role of DNA methylation in syndromic and non-syndromic congenital heart disease
Authors: Cao Jiali , Wu Qichang , Huang Yanru , Wang Lingye , Su Zhiying , Ye Huiming 
Published: April 2021

AbstractCongenital heart disease (CHD) is a common structural birth defect worldwide, and defects typically occur in the walls and valves of the heart or enlarged blood vessels. Chromosomal abnormalities and genetic mutations only account for a small portion of the pathogenic mechanisms of CHD, and the etiology of most cases remains unknown. The role of epigenetics in various diseases, including CHD, has attracted increased attention. The contributions of DNA methylation, one of the most important epigenetic modifications, to CHD have not been illuminated. Increasing evidence suggests that aberrant DNA methylation is related to CHD. Here, we briefly introduce DNA methylation and CHD and then review the DNA methylation profiles during cardiac development and in CHD, abnormalities in maternal genome-wide DNA methylation patterns are also described. Whole genome methylation profile and important differentially methylated genes identified in recent years are summarized and clustered according to the sample type and methodologies. Finally, we discuss the novel technology for and prospects of CHD-related DNA methylation.
Tissue-specific role and associated downstream signaling pathways of adiponectin
Authors: Roy Bipradas , Palaniyandi Suresh Selvaraj 
Published: April 2021

AbstractAccording to the World Health Organization, metabolic syndrome (MetS) can be defined as a pathological condition characterized by abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. The incidence of MetS keeps rising, as at least 35% of the USA population suffers from MetS. One of the worst comorbidities of metabolic syndrome are cardiovascular diseases that significantly amplifies the mortality associated with this syndrome. There is an urgent need to understand the pathophysiology of MetS to find novel diagnosis, treatment and management to mitigate the MetS and associated complications. Altered circulatory adiponectin levels have been implicated in MetS. Adiponectin has numerous biologic functions including antioxidative, anti-nitrative, anti-inflammatory, and cardioprotective effects. Being a pleiotropic hormone of multiple tissues, tissue-specific key signaling pathways of adiponectin will help finding specific target/s to blunt the pathophysiology of metabolic syndrome and associated disorders. The purpose of this review is to elucidate tissue-specific signaling pathways of adiponectin and possibly identify potential therapeutic targets for MetS as well as to evaluate the potential of adiponectin as a biomarker/therapeutic option in MetS.
Critical illness-related corticosteroid insufficiency during difficult weaning from mechanical ventilation
Authors: Bagate François , Bedet Alexandre , Tomberli Françoise , Boissier Florence , Razazi Keyvan , de Prost Nicolas , Carteaux Guillaume , Mekontso Dessap Armand 
Published: April 2021

Abstract
Background
Critical illness-related corticosteroid insufficiency (CIRCI) is common during critical illness and is usually associated with poor outcomes, as prolonged duration of mechanical ventilation (MV) and higher mortality. CIRCI may alter cardiac and vascular functions. Weaning-induced pulmonary oedema (WiPO) is a major mechanism of weaning failure. The aim of this study was to evaluate the role of CIRCI in patients with difficult ventilator weaning and its possible relation with WiPO.

Methods
This is a prospective study conducted in the intensive care of a university hospital in France. Patients under MV for more than 24 h, meeting weaning criteria and having failed the first spontaneous breathing trial (SBT) underwent a corticotropin stimulation test, with assessment of total blood cortisol levels immediately before (T0) 0.25 mg iv of tetracosactrin and 30 and 60 min afterward. Δmax was defined as the difference between the maximal value after the test and T0. CIRCI was defined as T0 < 10 μg/dL (276 nmol/L) and/or Δmax < 9 μg/dL (248 nmol/L) and inadequate adrenal reserve as Δmax < 9 μg/dL. Biomarkers (natriuretic peptide and protidemia) sampling and echocardiograms were performed during the second SBT and were used to diagnose WiPO, which was defined according to two definitions (one liberal and one conservative) derived from recent publications on the topic. Successful extubation was defined as patient alive without reintubation 7 days after extubation. A competing risk analysis was used to assess extubation failure and mortality.

Results
Seventy-six consecutive patients (63 ± 14 years; 49 men) with difficult weaning were enrolled. CIRCI and inadequate adrenal reserve occurred in 25 (33%) and 17 (22%) patients, respectively. The probability of successful extubation was significantly decreased in patients with CIRCI or inadequate adrenal reserve, as compared to their counterparts, and this association persisted after adjustment on severity (SOFA score at first SBT). WiPO occurred in 44 (58%) and 8 (11%) patients, according to the liberal and conservative definition, respectively. WiPO was not associated with CIRCI nor with inadequate adrenal reserve.

Conclusion
CIRCI was common during difficult weaning and was associated with its prolongation. We did not find a significant association between CIRCI and WiPO.
Infinite number of solutions for some elliptic eigenvalue problems of Kirchhoff-type with non-homogeneous material
Authors: Yan Baoqiang , O’Regan Donal , Agarwal Ravi P. 
Published: April 2021

AbstractIn this paper, using variational method, we study the existence of an infinite number of solutions (some are positive, some are negative, and others are sign-changing) for a non-homogeneous elliptic Kirchhoff equation with a nonlinear reaction term.
Caregivers: the potential infection resources for the sustaining epidemic of hand, foot, and mouth disease/herpangina in Guangdong, China?
Authors: Liu Jundi , Chen Yan , Hu Peipei , Gan Lin , Tan Qimin , Huang Xinqiao , Ma Zhanzhong , Lin Cuiji , Wu Dawei , Zhu Xun , Zhang Dingmei 
Published: April 2021

Abstract
Background
Although several measures have been taken to control hand foot and mouth disease (HFMD) and herpangina (HA), these two diseases have been prevalent in China for 10 years with high incidence. We suspected that adults’ inapparent infection might be the cause of the continued prevalence of HFMD/HA infection in mainland China.

Methods
To explore the role of adults (especially caregivers) in the transmission process of HFMD/HA among children, 330 HFMD/HA cases and 330 healthy children (controls) were selected for a case–control study. Then, data were analyzed by logistic regression.

Results
Single-variable analyses revealed that caregivers who tested positive for enterovirus was a significant risk factor of HFMD/HA transmission to children (adjusted odds ratio (OR) = 9.22; 95% CI, 1.16 to 73.23). In the final multivariable model, caregiver behavior, such as cooling children’s food with mouth (OR = 1.85; 95% CI, 1.11 to 3.08) and feeding children with their own tableware (OR = 2.19; 95% CI, 1.07 to 4.45), significantly increased the risk of transmitting HFMD/HA to children. On the contrary, washing hands before feeding children reduced such risk.

Conclusions
These results implied that the caregivers might be the infectious source or carriers of enterovirus. Therefore, preventing or treating the caregivers’ enterovirus infection and improving their hygiene habits, especially when they are in contact with children, could provide a breakthrough for the effective control of HFMD/HA.
The influence of late retirement on health outcomes among older adults in the policy context of delayed retirement initiative: an empirical attempt of clarifying identification bias
Authors: Li Jiannan , Yuan Bocong , Lan Junbang 
Published: April 2021

Abstract
Background
The deepening population aging is urging policy makers to launch delayed retirement initiative, when the society is faced with unprecedented challenges of shrinking labor supply, heavier pension burdens and slowing economic growth. However, the health outcomes of late retirees receive scarce attention due to the intrinsic identification difficulties (i.e., (1) self-selection bias – older adults with predetermined ill-health are less likely to delay retirement. (2) there can be situations where the status of late retirement has terminated at the time of interview, although he/she has ever delayed retirement). To fill in this research gap, this study examines the effect of late retirement on the difficulty in physical functioning and problems of cognitive status among older adults.

Method
Using the data from China Health and Retirement Longitudinal Study (CHARLS-2015 harmonized, and CHARLS-2018), this study investigates the influence of late retirement (year 2015) on the difficulty in physical functioning and problems of cognitive status (year 2018) among older adults. A series of robustness checks are also conducted.

Results
Empirical results show that late retirement is associated with better physical functioning and cognitive status. The influence remains robust after considering potential self-selection bias and the sensitivity of including/excluding older adults who have past late retirement experience but have no longer been late retirees at the time of survey.

Conclusion
This study suggests that older adults might benefit from the engagement in late careers in their physical and cognitive functioning.
Multiresidue analysis of 184 pesticides in high-fat fish feed using a new generic extraction method coupled with gas and liquid chromatography-tandem mass spectrometry
Authors: Eyring Philipp Rudolf Michael Peter , Herrmann Susan Strange , Poulsen Mette Erecius 
Published: April 2021

AbstractAnimal feed is typically plant-based and can contain pesticide residues. Methods for testing food and feed samples, such as the Quick Easy Cheap Effective Rugged Safe (QuEChERS) method or the Swedish Ethyl Acetate (SweEt) method, successfully extract many pesticide residues. However, nonpolar pesticides, such as organochlorine pesticides, show poor recovery when extracted from lipid-rich samples. The previously developed water-acetonitrile-heptane-solid-phase-extraction (WAHSPE) method shows better recoveries for the nonpolar pesticides but requires two injections per sample and per instrument. Here, we present a modified version of the WAHSPE method for pesticides in fish feed using one injection per sample and per instrument. Of the 184 pesticides tested, 179 met the European Union Legislation’s validation criteria at a spike level of 50 μg/kg, showing recoveries between 70 and 120% and a relative standard deviation (RSD) below 20%. Organochlorine pesticides accounted for 14 of the tested compounds.