bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mid-term functional and quality of life outcomes of robotic and laparoscopic ventral mesh rectopexy: multicenter comparative matched-pair analyses
Authors: Laitakari K. E. , Mäkelä-Kaikkonen J. K. , Kössi J. , Kairaluoma M. , Koivurova S. , Pollari L. , Ohtonen P. , Rautio T. T. 
Published: December 2021

Abstract
Background
The aim of this study was to compare patients’ mid-term functional and quality of life (QoL) outcomes following robotic ventral mesh rectopexy (RVMR) and laparoscopic ventral mesh rectopexy (LVMR).

Methods
The data of consecutive female patients who underwent minimally invasive ventral mesh rectopexy for external or symptomatic internal rectal prolapse at 3 hospitals in Finland between January 2011 and December 2016 were retrospectively collected. Patients were matched by age and diagnosis at a 1:1 ratio. A disease-related symptom questionnaire was sent to all living patients at follow-up in July 2018.

Results
After a total of 401 patients (RVMR, n = 187; LVMR, n = 214) were matched, 152 patients in each group were included in the final analyses. The median follow-up times were 3.3 (range 1.6–7.4) years and 3.0 (range 1.6–7.6) years for the RVMR and LVMR groups, respectively. The postoperative QoL measures did not differ between the groups. Compared with the LVMR group, the RVMR group had lower postoperative Wexner Incontinence Score (median 5 vs. median 8; p < 0.001), experienced significant ongoing incontinence symptoms less often (30.6% vs. 49.0%; p < 0.001) and reported less postoperative faecal incontinence discomfort evaluated with the visual analogue scale (median 11 vs. median 39; p = 0.005). RVMR patients had a shorter hospital stay (2.2 days vs. 3.8 days; p < 0.001) but experienced more frequent de novo pelvic pain (31.8% vs. 11.8%; p < 0.001).

Conclusion
RVMR and LVMR patients had equal functional and QoL outcomes. Those who underwent RVMR had lower mid-term anal incontinence symptom scores but suffered more frequent de novo pelvic pain.
Right out of the gate: the genomics of Lessepsian invaders in the vicinity of the Suez Canal
Authors: Azzurro Ernesto , Nourigat Mathilde , Cohn Francesca , Ben Souissi Jamila , Bernardi Giacomo 
Published: December 2021

AbstractMarine organisms that enter the Mediterranean from the Red Sea via the Suez Canal are known as Lessepsian bioinvaders. In general, genetic studies of Lessepsian fishes have shown little structure between Red Sea and Mediterranean populations. Yet notable exceptions suggest the importance of life-history factors that may influence patterns of spatial genetic variation. In this study, by sampling two invasive fishes with different life histories (the rabbitfish Siganus rivulatus and the filefish Stephanolepis diaspros), we looked at evidence of population structure and selection at the boundary between the Red Sea and the Mediterranean (the Suez Canal), using thousands of molecular markers. Results illustrate two divergent patterns of genetic patterns, with little genetic structure in S. rivulatus and strong population structure in S. diaspros, even at such small spatial scale. We discuss differences in ecological characteristics between the two species to account for such differences. In addition, we report that in the face of both high (S. rivulatus) and low (S. diaspros) gene flow, loci under selection were uncovered, and some protein coding genes were identified as being involved with osmoregulation, which seems to be an important feature of individuals crossing the salinity-variable Suez Canal. The presence of genes under selection in populations near the Suez Canal supports the idea that selection may be active and essential for successful invasions right out of the gate.
Fast quantification of extracellular vesicles levels in early breast cancer patients by Single Molecule Detection Array (SiMoA)
Authors: Morasso Carlo , Ricciardi Alessandra , Sproviero Daisy , Truffi Marta , Albasini Sara , Piccotti Francesca , Sottotetti Federico , Mollica Ludovica , Cereda Cristina , Sorrentino Luca , Corsi Fabio 
Published: December 2021

Abstract
Purpose
Preliminary reports suggest that extracellular vesicles (EVs) might be a promising biomarker for breast cancer (BC). However, the quantification of plasmatic levels of EVs is a complex task. To overcome these limitations, we developed a new, fast, and easy to use assay for the quantification of EVs directly in plasma based on the use of Single-Molecule Array (SiMoA).

Methods
By using SiMoA to identify CD9+/CD63+ EVs, we analyzed plasma samples of 181 subjects (95 BC and 86 healthy controls, HC). A calibration curve, made of a serial dilution of lyophilized standards from human plasma, was used in each run to ensure the obtainment of quantitative results from the assay. In a subgroup of patients, EVs concentrations were estimated in plasma before and after 30 days from cancer surgery. Additional information on the size of EVs were also acquired using a Nanosight system to obtain a clearer understanding of the mechanism underlying the releases of EVs associated with the presence of cancer.

Results
The measured levels of EVs resulted significantly higher in BC patients (median values 1179.1 ng/µl vs 613.0 ng/µl, p < 0.0001). ROC curve was used to define the optimal cut-off level of the test at 1034.5 ng/µl with an AUC of 0.75 [95% CI 0.68–0.82]. EVs plasmatic concentrations significantly decreased after cancer surgery compared to baseline values (p = 0.014). No correlation was found between EVs concentration and clinical features of BC.

Conclusion
SiMoA assay allows plasmatic EVs levels detection directly without any prior processing. EVs levels are significantly higher in BC patients and significantly decreases after cancer surgery.
Exploring Interactions in the Sickness Insurance System in Terms of Power and Trust
Authors: Karlsson Elin A. , Sandqvist Jan L. , Seing Ida , Ståhl Christian 
Published: December 2021

AbstractPurpose Activation policies and efforts to reduce sick leave rates has influenced sickness insurance systems in Western countries, which has led to social security being more connected with work and attempts to expose malingering among the sickness absent. The aim of this study was to explore how power and trust are expressed by clients and stakeholders within the Swedish sickness insurance system. Methods This was a longitudinal qualitative study based on semi structured interviews and case files from 31 clients on sick leave in Sweden. Data was analyzed using a thematic analysis. Results The main theme ‘Acts of power and distrust’ illustrates how stakeholders’ express suspicions towards each other, and how clients need to demonstrate desire and efforts to return to work which other stakeholders verified. Conclusions The clients desire to prove themselves able to contribute to society was prominent in this study and power relations need to be acknowledged, in particular between client and the SIA. Further, to preserve citizens trust in the system, the system needs to demonstrate trust also in the clients.
ROmodel: modeling robust optimization problems in Pyomo
Authors: Wiebe Johannes , Misener Ruth 
Published: December 2021

AbstractThis paper introduces ROmodel, an open source Python package extending the modeling capabilities of the algebraic modeling language Pyomo to robust optimization problems. ROmodel helps practitioners transition from deterministic to robust optimization through modeling objects which allow formulating robust models in close analogy to their mathematical formulation. ROmodel contains a library of commonly used uncertainty sets which can be generated using their matrix representations, but it also allows users to define custom uncertainty sets using Pyomo constraints. ROmodel supports adjustable variables via linear decision rules. The resulting models can be solved using ROmodels solvers which implement both the robust reformulation and cutting plane approach. ROmodel is a platform to implement and compare custom uncertainty sets and reformulations. We demonstrate ROmodel’s capabilities by applying it to six case studies. We implement custom uncertainty sets based on (warped) Gaussian processes to show how ROmodel can integrate data-driven models with optimization.
Genetic diversity of oral streptococci in the guinea pig as assessed by sequence analysis of the 16S rRNA and groEL genes
Authors: Król Jarosław , Nowakiewicz Aneta , Błaszków Alicja , Brodala Maria , Domagała Adrianna , Prassol Anna-Nicole , Sławska Dominika , Wojtynia Julita 
Published: December 2021

AbstractThe aim of the present study was to characterize bacteria of the genus Streptococcus isolated from the oral cavity of the guinea pig as well as to assess the significance of these microorganisms as potential veterinary and human pathogens. Sixty-two streptococcal isolates recovered from 27 clinically healthy guinea pigs were examined genotypically by sequencing the 16S rRNA and groEL genes. Among these isolates, only 13 could be assigned to a species described previously (mainly Streptococcus parasanguinis, S. mitis and S. suis), and the majority of the remaining ones differed considerably from the streptococcal species known to date (16S rRNA and groEL sequence similarities were < 97% and < 87%, respectively). Based on 16S rRNA sequences, these unidentified isolates were divided into seven groups (clades), of which clades I through III comprised most of the isolates examined and had also the widest distribution among guinea pig colonies. Upon groEL gene sequence analysis, however, members of the three clades grouped together without forming such distinct clusters. The remaining clades distinguished by 16S rRNA sequencing could also be discerned by the second gene, and they contained only a few isolates often restricted to one or a few animal colonies. The present work reveals that the guinea pig mouth is inhabited by a vast number of phylogenetically diverse, so far unrecognized populations of streptococci, most of them being apparently host-specific genomospecies. On the contrary, S. parasanguinis and S. mitis are also common human commensals and S. suis is a well-recognized zoonotic pathogen.
Epigenetic Copper Mineralization in Raipur-Mokhampura Area, Mangalwar Complex, Bhilwara District, Rajasthan
Authors: Puspalak Binamra , Panda Lopamudra , Mukhopadhyay Shubhabrata 
Published: December 2021

Abstract
Rocks of the Mangalwar and Sandmata Complex of the Bhilwara Supergroup of Archaean age host copper mineralization in the form of chalcopyrite-bornite in Raipur-Mokhampura and Rajaji ka Karera areas of Bhilwara district, Rajasthan. The area forms a part of the dismembered granite-greenstone sequence of the Bhilwara Supergroup. Chalcopyrite and bornite form the dominant copper sulphides along with pyrite, digenite, chalcocite and some accessory Bi-telluride and Bi-Cu sulphide phases. These sulphides occur along the S2 foliation planes, veins and fractures within the amphibolites and calc-gneiss. Presence of Bi indicates hydrothermal epigenetic nature of the mineralization developed under highly acidic reducing condition and high sulphur fugacity.
Coralline Algae from the Late Pleistocene Miliolite Formation of Kachchh, Western India
Authors: Mude Shyam N. , Kundal Pradeep , Raut Shashikant D. 
Published: December 2021

Abstract
Coralline algae of the Late Pleistocene Miliolite Formation of Kachchh region, Gujarat, western India are studied in terms of taxonomy and their paleoenvironmental implications. The Quaternary bio-clastic sediments belonging to the Late Pleistocene Miliolite Formation are well exposed in Kachchh, western India and these sediments consist of sandy limestones and calcareous sandstones. The present paper deals with the study of coralline algae from the sediments of the Late Pleistocene Miliolite Formation. Twenty two species of coralline algae are being recorded for the first time from these sediments. Out of twenty two species, eight belong to non-geniculate coralline algae and fourteen belong to geniculate coralline algae. The geniculate coralline algal species are: Lithophyllum incrustans Philippi, Lithophyllum sp.1, Lithopyllum sp.2, Lithoporella melobesioides Foslie, Lithothamnion sp.1, Lithothamnion sp.2, Lithothamnion sp.3 and Lithothamnion sp.4 and geniculate coralline algal species are: Amphiroa anchiverricosa Johnson and Ferris, A. fortis Johnson , A. rigida Lamouroux; Arthrocardia cretacica Raineri, A. indica Kundal and Humane, A. konitaensis Ishijima; Calliarthron antiquum Johnson; Corallina grandis Rao, C. prisca Johnson, C. typica Ishijima; Jania guamensis Johnson, J. mengaudi Lemoine, J. sripadaraoi Kundal and Humane; J. vetus Johnson. The present coralline algal assemblage suggests that the sediments containing algae from the Miliolite Formation were deposited in the shallow water marine/ beach environment.
Application of Microseismic Monitoring in Analysing the Stability of Underground Cavern
Authors: Kumar Vikalp , Jha Prakash Chandra , Singh Nagendra Pratap , Cherukuri Sivakumar 
Published: December 2021

Abstract
Long term stability of an underground cavern is significant for construction engineers. For structures constructed in the geologically active regions of the Himalayas, continuous monitoring is required to ward off the sustained threats due to seismic activities and associated local geological hazards. Underground powerhouse of Tapovan Vishnugad Hydropower Power Project (TVHPP), Chamoli, Uttarakhand is one such powerhouse that encountered various types of rockmass failures both during and post construction. The project area is located about 2.0 km north of the Main Central Thrust (MCT) and the rockmass cavern has numerous joints, shear and seam zones and fractures. This pose threat to the long term stability of this underground powerhouse cavern. To analyse the rockmass stability of the powerhouse, real time microseismic monitoring system was installed in this underground cavern. Spatio-temporal variation of the recorded seismic events has been analysed for microseismic events distribution in terms of seismic energy, displacement, cumulative apparent volume and various other contours led to the identification of potentially hazardous zones in the underground rockmass structure.
Suitability of Groundwater Quality with Precipitation in the Western Part of Indo-Gangetic Plain, Uttar Pradesh
Authors: Singh Daya Shankar , Mishra Ajai 
Published: December 2021

Abstract
In this study, the study area has been classified into two parts as the city area and the critical area on the basis of different uses and demands. About two decades groundwater samples were collected and analyzed for the drinking and irrigation water quality parameters such as water quality index (WQI) and sodium absorption ratio (SAR) respectively. A graph has been plotted amongst water quality index, SAR values, and precipitation. It shows that WQI of critical area and city area is directly proportional to SAR values while the precipitation has a reverse correlation with the SAR and WQI for both the areas at a certain range. The response of precipitation and parameters is not the same for both the areas because the availability of open area is high in critical areas while very low in the city area. Each groundwater sample was also analyzed for both the parameters and also compared with the standards of World Health Organization, 2017, and Bureau of Indian Standards, 2012. Therefore it can be suggested that a proper drainage network and water harvesting structures should be constructed for the heavy rain period and lean period respectively for the sustainable groundwater resources.
An Integrated Approach for Delineating and Characterizing Groundwater Depletion Hotspots in a Coastal State of India
Authors: Basak Amiya , Das Jayanta , Rahman A.T.M. Sakiur , Pham Quoc Bao 
Published: December 2021

Abstract
Visualization of present state of aquifers and identification of groundwater depletion hotspots are important tools in preparing an effective groundwater management plan. Therefore, this study developed an integrated framework by bridging a number of relevant factors to characterize and visualize groundwater depletion hotspots in Andhra Pradesh, India. Firstly, the groundwater status was assessed by detecting spatio-temporal trends in groundwater levels of 429 dug well sites from 2004 to 2018 using Mann-Kendall (MK)/modified Mann-Kendal (mMK), Spearman’s Rho test, and the magnitude of the slope was determined by Sen’s slope estimator. Subsequently, multiple decision factors were considered in the analytical hierarchy process (AHP) method for producing the groundwater stress zone map. A multicollinearity test was performed prior to the incorporation of these factors in order to improve the decision-making power of the AHP method. The results of the groundwater stress zoning map showed that 19.99%, 16.93%, 24.63%, 18.86% and 19.59 % of areas were classified as low, moderate, high and very high stress zones, respectively. Results also identified the south-western parts as groundwater depletion hotspots. Furthermore, validation results using Sen’s slope map, evaluation metrics of ROC (receiver operating characteristics) and AUC (area under curve) showed that AHP method had exhibited a reliable performance with an accuracy of 76.7%. Thus, the applied integrated approach can be used to explicitly characterize groundwater status by integrating different factors. The findings of our study also would be helpful for water resources managers and planners who need to design proper and sustainable management of groundwater resources.
Alarming Realities of Groundwater Dynamics in Basaltic Region through RS, GIS-Based Retrieval of Historical Data
Authors: Chaware Snehalata , Patil Nitin , Patil Adwait 
Published: December 2021

Abstract
A concept of retrieving and monitoring groundwater dynamics was introduced via metrics derived using Remote Sensing (RS) and Geographic Information Systems (GIS) in the basaltic region, namely the Euclidian distance between neighbouring irrigation wells, area irrigated per well, well density and cluster analysis. In a representative Nagjhari watershed (14823 ha) located in Maharashtra state, India, temporal Google Earth images were interpreted visually to retrieve the periodic (2007, 2013, 2017), historical dugout well related data. During the decade, the number of wells increased by 429 (64%) with a 7% decrease in irrigated area, implying a greater number of competing users, tapping the same aquifer leading to the increased cost of irrigation. In 2007, functional wells (368) outnumbered defunct wells (303). By 2017, the reversal was far greater with 698 defunct wells compared to 399 functional wells. Clusters of 5-10, 10-15, and &gt;15 number of wells respectively with 500 m proximity showed a common trend of a rising number of defunct wells (303 to 698), a decline in the total irrigated area in the watershed (from 517 to 479 ha), and irrigated area per unit well (from 1.41 to 1.23 ha) accompanied by a decrease in inter-well distance from 250 to 110 m. The well density increased from 0.035 to 0.25 units per ha. Neural clustering proved effective in discovering and delineating an aquifer located between 310-330 m contour classes. Three ‘hot spots’ of high well density, lower inter-well distance, and irrigated area per well were mapped. Observation wells monitored by the Central Ground Water Board were located within 460 m from the functional wells raising concerns about their representative character. An alarming trend of the rising number of competing groundwater users, increasing demand but actual use limited by aquifer yield potential was noted with negative influence on well density, and investment of about INR 34.55 million wasted over a decade.
Finding a New Coal Seam in Chandra Area, Surguja District, Chattisgarh, India
Authors: Patel D R , Alexander P O , Dutta N K , Chauhan G R 
Published: December 2021

Abstract
A new coal seam is being reported in Chandra area (23°03′00″ to 23°10′00″ N, and 83°10′00″ to 83°20′00″ E), located southeast of Ambikapur, the district headquarter of Surguja district, Chhattisgarh, falling in Survey of India, Toposheet 64 M/8. This area is located to the southeast of well known Bisrampur and east of Lakhanpur coalfields in south Rewa Gondwana Masterbasin.
Lithostratigraphic sequence of the Chandra area comprises granite-gneisses, phyllite belonging to the Palaeo to Mesoproterozoic forming the western extension of Chhotanagpur Gneissic complex, and the Lower Gondwana Group comprising the Talchir Formation mainly represented by boulder beds (tilloid) and green shale overlain by the Barakar Formation comprising mainly sandstone (fluvial sequence). Barakar sandstone overlaps onto the granite gneiss (basement) at some places. Barakar Formation. Exposed in northeast of Chandra village contains coal seam of around 1.50 m thick is exposed in a nala section. Analysis results show that coal present in the area contains high volatile matters (21.65% to 31.10 %) and high ash yield which varies from 12.12 % to 51.90 % and grade of G2, G8 and G14, with useful heat value ranging between 6525 to1326 K Cal/kg. With the development of the Bisrampur coalfield and the railway line connecting Ambikapur with Annuppur (on South Eastern Railway) it is possible to develop mines in Chandra area.
Market-shaping phases—a qualitative meta-analysis and conceptual framework
Authors: Flaig Alexander , Kindström Daniel , Ottosson Mikael 
Published: December 2021

AbstractThis study explores the potential existence of reoccurring patterns in market-shaping processes by employing a qualitative meta-analysis to analyze 79 case studies on market-shaping. Through the evidence-based synthesis of qualitative data, we extract 20 generalized market-shaping activities that inform and form the foundation of a three-phased market-shaping process. This conceptual framework divides the market-shaping process into the phases of infusion, formation and retention. By applying our conceptual framework to the qualitative dataset, we explore the presence of market-shaping phases and provide further insights into the interdependences and dynamics between multiple, simultaneously occurring, market-shaping processes. By providing a structured market-shaping process, we attempt to reduce the overall complexity of the market-shaping phenomenon and facilitate the operationalization of the phenomenon for further market-shaping research. Additionally, our conceptualization provides practitioners with a framework to analyze the market-shaping efforts of other market actors and support the design of their own market-shaping strategies.