bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zacharias Frankel’s Conception of the Septuagint in Context
Authors: van der Louw Theo A.W. 
Published: July 2021

Abstract
Zacharias Frankel had a very low opinion of the abilities of the LXX translators, the quality of their work and the ensuing textual transmission. He considered the Septuagint only useful as a testimony to help prove the antiquity of the halakah, a notion with apologetic value. Methodologically, he conceptualized the genesis of the Greek Pentateuch through the theories of contemporary historical criticism. His monographs on the Septuagint display great continuity with early modern scholarship. This also holds true for the assumption that the Septuagint reflects Jewish interpretation, and the notion of five translators/editors for the Greek Pentateuch. Frankel’s works were considered important, but his innovations, viz. the insistence that all Jewish exegesis was Palestinian in origin and his rejection of textual criticism, were accepted by few and rejected by most scholars, Jews and Christians alike. Frankel’s boldness and his use of German helped to keep his ideas on the scholarly agenda.
Measuring Shallow Convective Mass Flux Profiles in the Trade Wind Region
Authors: Klingebiel Marcus , Konow Heike , Stevens Bjorn 
Published: July 2021

AbstractMass flux is a key quantity in parameterizations of shallow convection. To estimate the shallow convective mass flux as accurately as possible, and to test these parameterizations, observations of this parameter are necessary. In this study, we show how much the mass flux varies and how this can be used to test factors that may be responsible for its variation. Therefore, we analyze long-term Doppler radar and Doppler lidar measurements at the Barbados Cloud Observatory over a time period of 30 months, which results in a mean mass flux profile with a peak value of 0.03 kg m−2 s−1 at an altitude of ~730 m, similar to observations from Ghate et al. at the Azores Islands. By combining Doppler radar and Doppler lidar measurements, we find that the cloud-base mass flux depends mainly on the cloud fraction and refutes an idea based on large-eddy simulations that the velocity scale is in major control of the shallow cumulus mass flux. This indicates that the large-scale conditions might play a more important role than what one would deduce from simulations using prescribed large-scale forcings.
The joint impacts of Atlantic and Pacific multidecadal variability on South American precipitation and temperature
Authors: He Zhaoxiangrui , Dai Aiguo , Vuille Mathias 
Published: July 2021

AbstractSouth American climate is influenced by both Atlantic multidecadal variability (AMV) and Pacific multidecadal variability (PMV). But how they jointly affect South American precipitation and surface air temperature is not well understood. Here we analyze composite anomalies to quantify their combined impacts using observations and reanalysis data. During an AMV warm (cold) phase, PMV-induced JJA precipitation anomalies are more positive (negative) over 0°-10°S and southeastern South America, but more negative (positive) over the northern Amazon and central Brazil. PMV-induced precipitation anomalies in DJF are more positive (negative) over Northeast Brazil and southeastern South America during the warm (cold) AMV phase, but more negative (positive) over the central Amazon Basin and central-eastern Brazil. PMV’s impact on AMV-induced precipitation anomalies shows similar dipole patterns. The precipitation changes result from perturbations of the local Hadley and Walker Circulations. In JJA, PMV- and AMV-induced temperature anomalies are more positive (negative) over entire South America when the other basin is in a warm (cold) phase, but in DJF temperature anomalies are more positive (negative) only over the central Andes and central-eastern Brazil and more negative (positive) over southeastern South America and Patagonia. Over central Brazil in JJA and southern Bolivia and northern Argentina in DJF, the temperature and precipitation anomalies are negatively correlated. Our results show that the influence of Pacific and Atlantic multidecadal variability need to be considered jointly, as significant departures from the mean AMV or PMV fingerprint can occur during a cold or warm phase of the other basin’s mode.
CD4+ T cells sustain aggressive chronic lymphocytic leukemia in Eμ-TCL1 mice through a CD40L-independent mechanism
Authors: Grioni Matteo , Brevi Arianna , Cattaneo Elena , Rovida Alessandra , Bordini Jessica , Bertilaccio Maria Teresa Sabrina , Ponzoni Maurilio , Casorati Giulia , Dellabona Paolo , Ghia Paolo , Bellone Matteo , Calcinotto Arianna 
Published: July 2021

AbstractChronic lymphocytic leukemia (CLL) is caused by the progressive accumulation of mature CD5+ B cells in secondary lymphoid organs. In vitro data suggest that CD4+ T lymphocytes also sustain survival and proliferation of CLL clones through CD40L/CD40 interactions. In vivo data in animal models are conflicting. To clarify this clinically relevant biological issue, we generated genetically modified Eμ-TCL1 mice lacking CD4+ T cells (TCL1+/+AB0), CD40 (TCL1+/+CD40−/−), or CD8+ T cells (TCL1+/+TAP−/−), and we monitored the appearance and progression of a disease that mimics aggressive human CLL by flow cytometry and immunohistochemical analyses. Findings were confirmed by adoptive transfer of leukemic cells into mice lacking CD4+ T cells or CD40L or mice treated with antibodies depleting CD4 T cells or blocking CD40L/CD40 interactions. CLL clones did not proliferate in mice lacking or depleted of CD4+ T cells, thus confirming that CD4+ T cells are essential for CLL development. By contrast, CD8+ T cells exerted an antitumor activity, as indicated by the accelerated disease progression in TCL1+/+TAP−/− mice. Antigen specificity of CD4+ T cells was marginal for CLL development, because CLL clones efficiently proliferated in transgenic mice whose CD4 T cells had a T-cell receptor with CLL-unrelated specificities. Leukemic clones also proliferated when transferred into wild-type mice treated with monoclonal antibodies blocking CD40 or into CD40L−/− mice, and TCL1+/+CD40−/− mice developed frank CLL. Our data demonstrate that CD8+ T cells restrain CLL progression, whereas CD4+ T cells support the growth of leukemic clones in TCL1 mice through CD40-independent and apparently noncognate mechanisms.
Transcriptome analysis of resistant and susceptible mulberry responses to Meloidogyne enterolobii infection
Authors: Shao Hudie , Fu Yu , Zhang Pan , You Chunping , Li Chuanren , Peng Huan 
Published: July 2021

Abstract
Background
Mulberry (Morus alba L.) is an important sericulture crop; however, root-knot nematode infection seriously limits its production. Understanding the mechanism of interaction between mulberry and nematode is important for control of infection.

Results
Using sequencing and de novo transcriptome assembly, we identified 55,894 unigenes from root samples of resistant and susceptible mulberry cultivars at different stages after infection with the nematode Meloidogyne enterolobii; 33,987 of these were annotated in the Nr, SWISS-PROT, KEGG, and KOG databases. Gene ontology and pathway enrichment analyses of differentially expressed genes (DEGs) revealed key genes involved in hormone metabolic processes, plant hormone signal transduction, flavonoid biosynthesis, phenylpropanoid biosynthesis, and peroxisomal and photosynthetic pathways. Analysis of key trends in co-expression networks indicated that expression of unigenes 0,015,083, 0,073,272, 0,004,006, and 0,000,628 was positively correlated with resistance to M. enterolobii. Unigene 0015083 encodes tabersonine 16-O-methyltransferase (16OMT), which is involved in alkaloid biosynthesis. Unigene 0073272 encodes a transcription factor contributing to nitric oxide accumulation during plant immune responses. Unigenes 0,004,006 and 0,000,628 encode ERF and MYB transcription factors, respectively, involved in plant hormone signaling. We verified the accuracy of transcriptome sequencing results by RT-qPCR of 21 DEGs.

Conclusions
The results of this study increase our understanding of the resistance mechanisms and candidate genes involved in mulberry–M. enterolobii interaction. Thus, our data will contribute to the development of effective control measures against this pathogen.
Effectiveness of analgesia with hydromorphone hydrochloride for postoperative pain following surgical repair of structural congenital malformations in children: a randomized controlled trial
Authors: Pan Yongying , Wang Yimin , Lie Dongxu , Liu Di , Chen Xi , Wu Zeyan , Chen Liumei , Wang Huaizhen , Peng Liangming , Liang Huiying , Song Xingrong , Zhao Baisong 
Published: July 2021

Abstract
Background
Effective postoperative analgesia is needed to prevent the negative effects of postoperative pain on patient outcomes. To compare the effectiveness of hydromorphone hydrochloride and sufentanil, combined with flurbiprofen axetil, for postoperative analgesia in pediatric patients.

Methods
This prospective randomized controlled trial included 222 pediatric patients scheduled for repair of a structural congenital malformation under general anesthesia. Patients were randomized into 3 groups: hydromorphone hydrochloride 0.1 mg/kg (H1), hydromorphone hydrochloride 0.2 mg/kg; (H2) or sufentanil 1.5 µg/kg (S). Analgesics were diluted in 0.9% saline to 100 ml and infused continuously at a basic flow rate of 2 mL per h. The primary outcome measure was the Face, Legs, Activity, Cry, and Consolability (FLACC) pain score. Secondary outcomes included heart rate (HR), respiration rate (RR), SpO2, Ramsay sedation scores, scores on the Paediatric Anaesthesia Emergence Delirium (PAED) scale, adverse reactions, parent satisfaction with analgesia.

Results
The FLACC score was significantly lower in H1 and H2 groups compared to S. The Ramsay sedation score was significantly higher in H1 and H2 groups compared to S. Recovery time was shorter in H1 group compared to patients H2 group or S group. There were no significant differences in the PAED scale, HR, RR, SpO2, adverse reactions, satisfaction of parents with analgesia, or length and cost of hospital stay.

Conclusions
Hydromorphone hydrochloride is a more effective analgesic than sufentanil for postoperative pain in pediatric patients following surgical repair of a structural congenital malformation, however, hydromorphone hydrochloride and sufentanil had similar safety profiles in this patient population.

Trial registration
Chinese Clinical Trial Register ChiCTR-INR-17013935). Clinical trial registry URL: Date of registration: December 14, 2017.
An evaluation of performance measures for arterial brain vessel segmentation
Authors: Aydin Orhun Utku , Taha Abdel Aziz , Hilbert Adam , Khalil Ahmed A. , Galinovic Ivana , Fiebach Jochen B. , Frey Dietmar , Madai Vince Istvan 
Published: July 2021

Abstract
Background
Arterial brain vessel segmentation allows utilising clinically relevant information contained within the cerebral vascular tree. Currently, however, no standardised performance measure is available to evaluate the quality of cerebral vessel segmentations. Thus, we developed a performance measure selection framework based on manual visual scoring of simulated segmentation variations to find the most suitable measure for cerebral vessel segmentation.

Methods
To simulate segmentation variations, we manually created non-overlapping segmentation errors common in magnetic resonance angiography cerebral vessel segmentation. In 10 patients, we generated a set of approximately 300 simulated segmentation variations for each ground truth image. Each segmentation was visually scored based on a predefined scoring system and segmentations were ranked based on 22 performance measures common in the literature. The correlation of visual scores with performance measure rankings was calculated using the Spearman correlation coefficient.

Results
The distance-based performance measures balanced average Hausdorff distance (rank = 1) and average Hausdorff distance (rank = 2) provided the segmentation rankings with the highest average correlation with manual rankings. They were followed by overlap-based measures such as Dice coefficient (rank = 7), a standard performance measure in medical image segmentation.

Conclusions
Average Hausdorff distance-based measures should be used as a standard performance measure in evaluating cerebral vessel segmentation quality. They can identify more relevant segmentation errors, especially in high-quality segmentations. Our findings have the potential to accelerate the validation and development of novel vessel segmentation approaches.
Feasibility and first results of a prospective cohort study to investigate cisplatin-associated ototoxicity amongst cancer patients in South Africa
Authors: Paken Jessica , Govender Cyril D. , Pillay Mershen , Ayele Birhanu T. , Sewram Vikash 
Published: July 2021

Abstract
Background
Cervical cancer, one of the most common cancers affecting females in South Africa, commonly requires a cisplatin-based-treatment regimen, which has been associated with ototoxic side effects. However, cisplatin-associated ototoxicity is largely under-reported in South Africa, despite its impact of hearing loss having serious overt ramifications on the quality of life of these patients. Hence, a prospective cohort study was undertaken to assess the audiological changes in female cervical cancer patients receiving cisplatin therapy.

Objective
To present details of the feasibility study and initial results on hearing patterns in cervical cancer patients receiving cisplatin chemotherapy. .

Methods
Fifty cervical cancer patients commencing with cisplatin chemotherapy underwent audiological assessments at a hospital in South Africa at various time intervals. Assessments included case history, otoscopic examination, immittance audiometry, pure tone audiometry (including high-frequency audiometry), speech audiometry, and distortion product otoacoustic emission testing. Data analysis involved the use of descriptive statistics and the Cochran-Armitage trend test for a linear trend in proportions.

Results
Fifty participants, aged between 32 and 79 years (Mean: 53 years; SD = 11.00), were recruited. Clinical findings revealed an incidence of 100% ototoxic hearing loss at the one-month post-treatment, i.e., 98% after three cycles of cisplatin and 2% at one-month post-chemotherapy. Sensorineural hearing loss and high-frequency tinnitus were most common. Deterioration in hearing thresholds was more evident in the extended high-frequency range, with the number of “no-responses,” from 11,200 Hz to 20,000 Hz, increasing with each successive audiological evaluation. This study further indicated that recruitment and follow-up of study participants within a limited resource setting are possible. However, cognizance must be given to a multidisciplinary approach and constant engagement with participants through regular contact either telephonically or via a short-message-system.

Conclusion
Exposure to cisplatin treatment contributed to hearing loss in females with cervical cancer, highlighting the need for ototoxicity monitoring during chemotherapy treatments. Furthermore, the results indicate that it is possible to conduct prospective cohort studies, using a multidisciplinary approach in limited-resource environments with appropriate planning and training strategies, as this study was able to achieve its aim successfully.
Use of antithrombotics at the end of life: an in-depth chart review study
Authors: Huisman Bregje A.A. , Geijteman Eric C.T. , Arevalo Jimmy J. , Dees Marianne K. , van Zuylen Lia , Szadek Karolina M. , van der Heide Agnes , Steegers Monique A.H. 
Published: July 2021

Abstract
Background
Antithrombotics are frequently prescribed for patients with a limited life expectancy. In the last phase of life, when treatment is primarily focused on optimizing patients’ quality of life, the use of antithrombotics should be reconsidered.

Methods
We performed a secondary analysis of a retrospective review of 180 medical records of patients who had died of a malignant or non-malignant disease, at home, in a hospice or in a hospital, in the Netherlands. All medication prescriptions and clinical notes of patients using antithrombotics in the last three months of life were reviewed manually. We subsequently developed case vignettes based on a purposive sample, with variation in setting, age, gender, type of medication, and underlying disease.

Results
In total 60% (n=108) of patients had used antithrombotics in the last three months of life. Of all patients using antithrombotics 33.3 % died at home, 21.3 % in a hospice and 45.4 % in a hospital. In total, 157 antithrombotic prescriptions were registered; 30 prescriptions of vitamin K antagonists, 60 of heparins, and 66 of platelet aggregation inhibitors. Of 51 patients using heparins, 32 only received a prophylactic dose. In 75.9 % of patients antithrombotics were continued until the last week before death. Case vignettes suggest that inability to swallow, bleeding complications or the dying phase were important factors in making decisions about the use of antithrombotics.

Conclusions
Antithrombotics in patients with a life limiting disease are often continued until shortly before death. Clinical guidance may support physicians to reconsider (dis)continuation of antithrombotics and discuss this with the patient.
Effectiveness of iguratimod as monotherapy or combined therapy in patients with rheumatoid arthritis: a systematic review and meta-analysis of RCTs
Authors: Hu Chao-Jun , Zhang Li , Zhou Shuang , Jiang Nan , Zhao Jiu-Liang , Wang Qian , Tian Xin-Ping , Zeng Xiao-Feng 
Published: July 2021

AbstractBackgroundThis study aims to evaluate the efficacy and safety of the iguratimod (IGU) as monotherapy or combined therapy in patients with rheumatoid arthritis (RA) by using meta-analysis.MethodsWe searched Medline, EMBASE, Cochrane library, CNKI, Wanfang medical network from initial to 30 June, 2020, for randomized clinical trials (RCTs). Two authors independently screened the studies via reading the title, abstract, and full text. The risk of bias in individual studies was assessed using the Cochrane Risk of Bias tool. STATA 12.0 was used for pooled analysis of all included studies.ResultsA total of 23 RCTs were included in this analysis. Meta-analysis showed that patients in the IGU monotherapy or combined therapy group had significantly higher ACR20 (OR = 1.97, 95% CI 1.29 to 3.00,P= 0.002), lower DAS28-CRP (SMD = −3.49, 95% CI −5.40 to −1.58,P< 0.001) and DAS28-ESR (SMD = −2.61, 95% CI −3.64 to −1.57,P< 0.001), as well as shorter duration of morning stiffness (SMD = −2.06, 95% CI −2.86 to −1.25,P< 0.001) and lower HAQ score (SMD = −0.91, 95% CI −1.61 to −0.21,P= 0.011), than those received other disease-modifying antirheumatic drugs (DMARDs) monotherapy (primarily comprising methotrexate). For the safety profile, IGU monotherapy had similar risks for gastrointestinal reactions (P= 0.070), leucopenia (P= 0.309), increment in transaminase (P= 0.321), increase of ALT (P= 0.051), and liver damage (P= 0.182) to methotrexate monotherapy, and IGU combined with other DMARDs therapy did not increase the risks of these AEs (P> 0.05).ConclusionsOur evidence suggests that IGU is effective and tolerant as monotherapy or combined therapy especially with methotrexate in patients with active RA. IGU may be regarded as a potential alternative to methotrexate, and a preferable choice when combined with other DMARDs for the treatment of RA.
Personalized mechanical ventilation in acute respiratory distress syndrome
Authors: Pelosi Paolo , Ball Lorenzo , Barbas Carmen S. V. , Bellomo Rinaldo , Burns Karen E. A. , Einav Sharon , Gattinoni Luciano , Laffey John G. , Marini John J. , Myatra Sheila N. , Schultz Marcus J. , Teboul Jean Louis , Rocco Patricia R. M. 
Published: July 2021

AbstractA personalized mechanical ventilation approach for patients with adult respiratory distress syndrome (ARDS) based on lung physiology and morphology, ARDS etiology, lung imaging, and biological phenotypes may improve ventilation practice and outcome. However, additional research is warranted before personalized mechanical ventilation strategies can be applied at the bedside. Ventilatory parameters should be titrated based on close monitoring of targeted physiologic variables and individualized goals. Although low tidal volume (VT) is a standard of care, further individualization of VT may necessitate the evaluation of lung volume reserve (e.g., inspiratory capacity). Low driving pressures provide a target for clinicians to adjust VT and possibly to optimize positive end-expiratory pressure (PEEP), while maintaining plateau pressures below safety thresholds. Esophageal pressure monitoring allows estimation of transpulmonary pressure, but its use requires technical skill and correct physiologic interpretation for clinical application at the bedside. Mechanical power considers ventilatory parameters as a whole in the optimization of ventilation setting, but further studies are necessary to assess its clinical relevance. The identification of recruitability in patients with ARDS is essential to titrate and individualize PEEP. To define gas-exchange targets for individual patients, clinicians should consider issues related to oxygen transport and dead space. In this review, we discuss the rationale for personalized approaches to mechanical ventilation for patients with ARDS, the role of lung imaging, phenotype identification, physiologically based individualized approaches to ventilation, and a future research agenda.