bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sınırda kişilik bozukluğunda serum ürik asit seviyeleri ve dürtüsellikle ilişkisi
Authors: KAZĞAN Aslı , YILDIZ Sevler , KURT Osman , KORKMAZ Sevda 
Published: November 2021

Amaç: Çalışmanın amacı ilaç kullanımı olmayan sınırda kişilik bozukluğu (SKB) tanılı hastalardaki serum ürik asit seviyelerini incelemek ve bunun dürtüsellikle olabilecek olası ilişkisini araştırmaktır.
Gereç ve Yöntem: Bu çalışmaya SKB tanılı 69 hasta ve 54 sağlıklı kontrol grubu dahil edildi. Tüm katılımcılara sosyodemografik veri formu, Barratt Dürtüsellik Ölçeği Kısa Formu (BDÖ-11) uygulanmıştır. Ardından tüm katılımcılardan açlık venöz kan örnekleri alınarak serum ürik asit düzeyleri çalışılmıştır.
Bulgular: SKB tanılı hastalarda serum ürik asit seviyeleri, BDÖ-11 alt boyut ve toplam puanları ve BDÖ toplam puanı kontrol grubundan anlamlı şekilde yüksek bulunmuştur. Serum ürik asit seviyeleri ile BDÖ-11 ölçek puanı arasında pozitif yönde anlamlı bir korelasyon olduğu görülmüştür.
Sonuç: Bu çalışmada, ilaç kullanımı olmayan sınırda kişilik bozukluğu tanılı hastalarda kontrol grubuna göre daha yüksek serum ürik asit seviyelerini bildirilmiştir. Çalışmanın bulguları SKB tanılı hastalardaki dürtüselliğin biyolojik temellere dayandırılması açısından örnek oluşturabilir. SKB hastalarında ürik asit seviyeleri ile ilgili ileride yapılacak olan uzunlamasına ve deneysel çalışmalar bizlere bu hastalardaki dürtüselliğin tanı ve tedavisi açısından alternatif bir yol gösterecektir.
Production of barueiro seedlings in different substrates
Authors: Alves Naiara Ferreira , Costa Ana Claudia , Alvarenga Júlio Miguel 
Published: November 2021

Barueiro (Dipteryx alata Vog.) is one of the species native to the Brazilian cerrado that has economic potential. Thus, for the implantation of commercial orchards of this fruit tree, it is important to produce quality seedlings. This study aimed to evaluate the growth of barueiro seedlings under different substrates containing organic residues in the municipality of Nova Xavantina-MT. The experimental design used was randomized blocks (RBD), with 7 treatments (soil (control); soil + bovine manure (2: 1); soil + coffee husk (3: 1); soil + humus (2: 1); soil + coffee husk + humus (3: 1: 1); soil + coffee husk + bovine manure (3: 1: 1); and soil + humus + bovine manure (3: 1: 1)) and 4 replicates, with ten plants per plot, totaling 280 seedlings. Treatments consisted of substrates formulated with different proportions of soil, bovine manure, coffee husk and earthworm humus. Substrate containing only soil (control) provided greater plant height, stem diameter, number of leaves, number of leaflets, shoot and root fresh and dry mass and Dickson Quality Index. In general, residues tested did not favor the growth parameters evaluated, possibly because barueiro is a species native to the Cerrado, not very demanding in soil fertility. Under the conditions of this work, it is recommended the use of soil in the formulation of substrates to produce barueiro seedlings. The addition of organic matter to the soil had negative effect on seedling development.
Análise fitoquímica e avaliação da atividade antioxidante do extrato foliar de Cariniana estrellensis
Authors: Ribeiro Antonio Vycttor de Pádua , Leite Filho César Auladino Leite Filho , Garcia Jordana Lucio , Silva João Victor Morais , Aguiar Aline Aires 
Published: November 2021

A variedade dos metabólitos secundários que constituem as plantas, principalmente os com ação antioxidante, são de suma importância para o uso de seus extratos e moléculas isoladas na prevenção de doenças. Devido à ação antioxidante de compostos secundários, como os fenólicos e os cumarínicos, presentes nos extratos de muitas plantas, há uma relação com a redução dos danos oxidativos celulares originados por espécies reativas de oxigênio e nitrogênio, sendo a Cariniana estrellensis, que é também popularmente conhecida como jequitibá-branco, rica em fitocompostos do metabolismo secundário. Trata-se de uma espécie arbórea climática neotropical, predominante no cerrado brasileiro, na qual tem uso medicinal recomendada para inflamações de mucosas e faringite. Este trabalho teve como objetivos determinar e caracterizar os compostos químicos presentes nas folhas de C. estrellensis e avaliar a atividade antioxidante delas. Na avaliação da atividade antioxidante, foi utilizado o método de sequestro do radical livre DPPH (1,1-Difenil-2-picril-hidrazil). O conteúdo fenólico total foi quantificado pelo método de Folin-Ciocalteu em conjunto com o método de precipitação da caseína. Com os percentuais dos compostos secundários, principalmente os de ação antioxidante, e a capacidade de sequestro de hidrogênio , demonstrou-se que o extrato foliar de Cariniana estrellensis tem efeito análogo ao do ácido ascórbico, um potente antioxidante encontrados em frutas cítricas.
Tensile Failure and Fracture Width of Partially Permeable Wellbores with Applications in Lost Circulation Material Design
Authors: Nguyen Kien , Mehrabian Amin , Santra Ashok , Phan Dung 
Published: November 2021

SummaryEstimation of near-wellbore fracture widths remains central to designing the particle size distribution (PSD) and composition of lost circulation material (LCM) blends. Although elastic rock models are often used for this purpose, they fall short in capturing the substantial effect of pore fluid pressure on the fracture width. The problem is addressed in this paper by incorporating the poroelastic back stress in width estimation of axial fractures nearby an inclined wellbore. The poroelastic back stress is caused by a nonideal drilling fluid filter cake allowing for fluid pressure communication between the wellbore and pore space of the rock surrounding the wellbore. In this aspect, a proper definition of the filter-cake efficiency is made in terms of the wellbore pressure, far-field pore fluid pressure, and pore fluid pressure of the rock surrounding the wellbore. The value of this parameter is estimated from the standard drilling fluid filtration test results, as well as the formation rock permeability. The filter-cake efficiency is next used to develop the long-time, asymptotic analytical solution for the poroelastic stress of an inclined wellbore. By accounting for the obtained poroelastic back stress, an improved estimation of the wellbore tensile limit that depends on the filter-cake efficiency parameter is developed. For wellbore pressures beyond the wellbore tensile limit, the width of the near-wellbore fractures is estimated. The fracture width estimation is made through an analytical, dislocation-based fracture mechanics solution to the integral equation describing the nonlocal stress equilibrium along the fracture faces. The commonly practiced scheme for geometric design of LCM blends is enhanced by using the presented improvement in estimation of the near-wellbore fracture width. A case study is used to demonstrate the substantial effect of drilling fluid filtration properties and the resulting poroelastic back stress on the wellbore tensile limit, estimated fracture width, and consequently, composition of the recommended LCM blend.
A New Analytical Approach To Calculate a Slippage inside a Progressing Cavity Pump with a Metallic Stator Using a Middle Streamline and a Structural Periodicity
Authors: Om Il Lyong , Han Un Chol , Ryo Song Il , Kim Chun Yong , Sol Yong Nam 
Published: November 2021

Summary
Simplified and 3D models have been studied to predict the performance of progressing cavity pumps (PCPs). Simplified models were mainly made for metallic stator PCP performance. Their purpose was to represent the relationship between pump flow rate and differential pressure. Previous studies proposed to solve the system of mass conservation equations. In these studies, the geometry of the gap area was not clearly represented by neglecting the curvatures of stator and rotor. In addition, only frictional loss was considered, but local loss by gradual contraction or expansion of the gap area was not considered.
In this study, we present a new analytical approach considering curvature and local loss. The depth of the gap area and local loss could be calculated analytically by a middle streamline and a curvature. On the basis of periodicity of distribution of cavities, simplified calculation for a slippage was possible without a system of mass conservation equations. Therefore, this model represents clearer geometry and a more simplified approach. The results show that this model shortens the calculating time and facilitates programing; in addition, the model validation is good in matching with experimental data.
Mass spectrometry-based proteomic analysis of NSCLC tumor and biopsy samples
Authors: Lehtiö Janne , Arslan Taner , Siavelis Ioannis , Pan Yanbo , Socciarelli Fabio , Berkovska Olena , Umer Husen M. , Mermelekas Georgios , Pirmoradian Mohammad , Jönsson Mats , Brunnström Hans , Brustugun Odd Terje , Purohit Krishna Pinganksha , Cunningham Richard , Asl Hassan Foroughi , Isaksson Sofi , Arbajian Elsa , Aine Mattias , Karlsson Anna , Kotevska Marija , Hanson Carsten Gram , Haakensen Vilde Drageset , Helland Åslaug , Tamborero David , Johansson Henrik J. , Branca Rui M. , Planck Maria , Staaf Johan , Orre Lukas M. 
Published: November 2021

Abstract
The associated publication reports proteogenomic analysis of non-small cell lung cancer, where we identified molecular subtypes with distinct immune evasion mechanisms and therapeutic targets, and validated our classification method in separate clinical cohorts. This protocol describes the sample preparation and mass spectrometry (MS)-based in-depth and rapid proteomic analyses of tumor and biopsy samples. We deployed single-pot solid-phase-enhanced sample preparation (SP3). For the in-depth analysis, we used TMT labeling, followed by high-resolution isoelectric focusing (HiRIEF) prefractionation and LC-MS with data-dependent acquisition (DDA). The reported protocol achieved analytical depth of close to 14,000 quantified proteins and almost 10,000 across the entire cohort of 141 samples. The rapid analysis was label-free, based on LC-MS with data-independent acquisition (DIA). The median number of identified proteins was 3,967 and 3,552 in two independent cohorts of tumor samples (n = 141 and 208, respectively), and 2,494 in another cohort of biopsy material (n = 84).
The Gaming Problem: A Latent Class Analysis of DSM-5 Criteria For Internet Gaming Disorder In A Non-Clinical Sample
Authors: Raybould Jodie N. , Watling Dylan C. , Larkin Michael M. , Tunney Richard J. 
Published: November 2021

Abstract
Background: We aimed to test whether suggested DSM-5 criteria for Internet Gaming Disorder (IGD) share a similar latent structure to formally recognised addiction. Methods: To do this we used latent class analysis on a dichotomous measure of IGD. The data was collected from a convenient general population sample (500) and a targeted gaming forum sample (236). Results: We found a four or six-class model to be most appropriate, ranging from ‘casual/non-gamer’ to ‘potentially disordered’ with increasing symptom severity. The majority of ‘potentially disordered’ gamers (5+ criteria) were found to be 18-30 years old, and no ‘potentially disordered’ gamers were over 42. Conclusion: The results suggest that gaming may share a similar latent structure to established addictions, with adolescents and young adults being more at risk. Studies replicating these results would be beneficial, with further emphasis on a critical evaluation of the criteria and symptom cut-off point.
Accuracy of High-risk HPV DNA PCR, p16INK4a Immunohistochemistry or the Combination of Both to Diagnose HPV-driven Oropharyngeal Cancer
Authors: Simoens Cindy , Gheit Tarik , Ridder Ruediger , Gorbaslieva Ivana , Holzinger Dana , Lucas Eric , Rehm Susanne , Vermeulen Peter , Lammens Martin , Vanderveken Olivier M. , Kumar Rekha Vijay , Gangane Nitin , Caniglia Alessandro , Maffini Fausto , Rubio Maria Belén Lloveras , Anantharaman Devasena , Chiocca Susanna , Brennan Paul , Pillai Madhavan Radhakrishna , Sankaranarayanan Rengaswamy , Bogers Johannes , Pawlita Michael , Tommasino Massimo , Arbyn Marc 
Published: November 2021

Abstract
BACKGROUNDThe incidence of high-risk human papillomavirus (hrHPV)-driven head and neck squamous cell carcinoma, in particular oropharyngeal cancers (OPC), is increasing in high-resource countries. Patients with HPV-induced cancer respond better to treatment and consequently have lower case-fatality rates than patients with HPV-unrelated OPC. These considerations highlight the importance of reliable and accurate markers to diagnose truly HPV-induced OPC. METHODSThe accuracy of three possible test strategies, i.e. a) hrHPV DNA PCR (DNA), b) p16INK4a immunohistochemistry (IHC) (p16), and c) the combination of both tests (considering joint DNA and p16 positivity as positivity criterion), was analysed in tissue samples from 99 Belgian OPC patients enrolled in the HPV-AHEAD study. Presence of HPV E6*I mRNA (mRNA) was considered as the reference, indicating HPV etiology. RESULTSNinety-nine OPC patients were included, for which the positivity rates were 36.4%, 34.0% and 28.9% for DNA, p16 and mRNA, respectively. Ninety-five OPC patients had valid test results for all three tests (DNA, p16 and mRNA). Using mRNA status as the reference, DNA testing showed 100% (28/28) sensitivity, and 92.5% (62/67) specificity for the detection of HPV-driven cancer. p16 was 96.4% (27/28) sensitive and equally specific (92.5%; 62/67). The sensitivity and specificity of combined p16+DNA testing was 96.4% (27/28) and 97.0% (65/67), respectively. In this series, p16 alone and combined p16+DNA missed 1 in 28 HPV driven cancers, but p16 alone misclassified 5 in 67 non-HPV driven as positive, whereas combined testing would misclassify only 2 in 67. CONCLUSIONSSingle hrHPV DNA PCR and p16INK4a IHC are highly sensitive but less specific than using combined testing to diagnose HPV-driven OPC patients. Since HPV-driven OPC cancer can be treated less aggressively, combined testing can reduce treatment sequelae at the expense of a small number of patients that may receive less effective therapy.
Temporal Changes In Cyclin D-CDK4/CDK6 And Cyclin E-CDK2 Pathways: Implications For The Mechanism of Deficient Decidualization In An Immune-Based Mouse Model of Unexplained Recurrent Spontaneous Abortion
Authors: Chang Zhuo , Kuang Hai-xue , Zhou Xueming , Zhu Hui , Zhang Yang , Fu Yin , Fu Qiang , Jiang Bei , Wang Wei , Jiang Sha , Ren Li , Ma Lei , Pan Xue , Feng Xiao-ling 
Published: November 2021

Abstract
Deficient endometrial decidualization has been associated with unexplained recurrent spontaneous abortion (URSA). However, the underlying mechanism is poorly understood. Here, we aimed to investigate the temporal cytokine changes and the involvement of the cyclin D-cyclin-dependent kinase (CDK)4/CDK6 and cyclin E-CDK2 pathways in the regulation of the G1 phase of the cell cycle during decidualization in a murine model of URSA. Serum and decidual tissues of URSA group and normal pregnant (NP) group mice were collected from gestation day 4 (GD4) to GD8. The embryo resorption and abortion rates were observed on GD8 and the decidual tissue status was assessed using hematoxylin and eosin staining. Cytokine levels in decidual tissues were analyzed using western blotting and reverse transcription polymerase chain reaction. We found that the embryo resorption rate was significantly increased in the URSA group compared to that in the NP group on GD8. The expression of the decidualization marker prolactin in the serum and decidual lysate of the URSA group was significantly decreased on GD6-8 compared to that of the NP group. Cyclin D, CDK4, CDK6, cyclin E, CDK2 and pRb levels in the URSA group mice were significantly lower compared to those in the NP group mice on GD6-8. Our results suggest that the hyperactivated cyclin D-CDK4/CDK6 and cyclin E CDK2 pathways inhibit the decidualization process on GD4, leading to deficient decidualization on GD8. Moreover, they clarify the role of cytokines in the cyclin D-CDK4/6 and cyclin E-CDK2 pathways during decidualization and provide new insight into URSA pathogenesis.
Th1/Th2 Cytokine Profiles Differentiating Tuberculous from Malignant Pleural Effusions: A Systematic Review and Meta-Analysis
Authors: Zeng Yulin , Wang Liwei , Zhou Hai , Qi Yu 
Published: November 2021

Abstract
To clarify which one has a different predominance of Th1 and Th2 immune responses in malignant and tuberculous pleural effusions. We did a meta-analysis of the results published previously to assess the levels of Th1/Th2 cytokines in two types of pleural effusion, and evaluated its ability to distinguish TPE from MPE. We queried the PubMed and Embase databases for studies indexed from 2000 up to March 2021. We included studies that (a) diagnosis of TPE and MPE by on culture, or pleural biopsy tissue provided; (b) compared levels of Th1/Th2 cytokines in pleural effusion between TPE and MPE. Pooled data by using a random-effects model or fixed-effects model, standardized mean differences (SMD) across studies comparing TPE and MPE. We also performed Egger test to assess of publication bias. Of 917 identified studies, a total of 42 studies were selected in the meta-analysis. Compared with malignant subjects, tuberculous subjects had a significant higher level of TNF-α [2.22, (1.60–2.84)], an elevated level of IFN-γ [3.30, (2.57–4.40)] in pleural effusion, a situation where the Th1 immune response dominates. Conversely, Interleukin-4 (IL-4) and IL-10 (Th2 cytokines) levels were higher in MPE than TPE. Besides, they were shown to be statistically insignificant tiny effects were [-0.15, (-0.94–0.63)], [-0.04, (-0.21–0.12)] respectively. We confirmed that pleural effusions caused by tuberculosis, a situation in which the Th1 cytokines are predominant. The slight preponderance of Th2 cytokines in malignant pleural effusions, which are not convincing enough to prove.
Fabrication of Covalently Linked Ruthenium Complex Onto Carbon Nitride Nanotubes For The Photocatalytic Degradation of Tetracycline Antibiotic
Authors: Nejad Mohaddeseh Shahabi , Vakily Zahra , Mostafavi Ali , Sheibani Hassan 
Published: November 2021

Abstract
Due to the problem of direct disposal of effluents contains antibiotics to the environment and the emergence of resistant bacterial pathogens, the wastewater treatment of pharmaceutical industry has known as an importance research background. In this study, the refinement and photodegradation ability of one of the most widely used antibiotics, “tetracycline” was investigated by ruthenium complex immobilized on the modified graphitic carbon nitride nanotubes. For this purpose, graphitic carbon nitride nanotubes (g-C3N4 NTs) were successfully synthesized by the hydrothermal method and functionalized with 1,10-Phenantroline-5,6-dione ligand during another step. Then, the functionalized g-C3N4 NTs were reinforced with immobilization of dichloro(p-cymene)ruthenium(II) dimer. The structure and morphology of the prepared photocatalyst was studied by X-ray diffraction (XRD), fourier transform infrared (FT-IR), scanning, and transmission electron microscopy (SEM & TEM) analyses. In the following, the photocatalyst's ability to optically degrade the tetracycline antibiotics was performed in a suspension reactor equipped with a LED lamp (60 W) and effective parameters such as the amount of catalyst, irradiation time, temperature, and pH were optimized. The results showed that the immobilization of Ru complex onto functionalized g-C3N4 NTs improved the photocatalytic activity and increased the degradation efficiencies to amount 43%. Furthermore, COD analysis was used for the determination of the amount of mineralization and results showed that the mineralization of 10 mg/L tetracycline solution of about 90% can be performed using 20 mg of Ru (II) complex/ g-C3N4 NTs at pH=7 after 480 min without any additive oxidant.
Association of Perioperative Cell-free DNA (cfDNA) Concentrations with Risk of Recurrence in Patients with Breast Cancer
Authors: Hassan Fara , Wang Jiang Huai , Cullinane Carolyn , Ita Michael , Corrigan Mark , O'Leary Donal Peter , Redmond Henry Paul 
Published: November 2021

Abstract
Background: Circulating cell-free DNA (cfDNA) is a potential biomarker of disease status in cancer patients and provides valuable diagnostic and prognostic information in breast cancer. In this study, we sought to quantify the cfDNA concentrations in the perioperative period and to investigate its prognostic relevance in breast cancer patients.Methods: Sixty-three (n=63) breast cancer patients undergoing curative surgery were screened for inclusion. Blood samples were collected: pre-operatively (Pre-op), post-operatively (POD) within weeks 1-2, weeks 3-4 and weeks 5-12 following surgery. cfDNA was extracted and quantified using nanodrop spectrophotometer. All patients were followed up for 5 years.Results: The median age was 52(26-84) years. During the perioperative period, patients with high cfDNA concentrations(cutoff:480ng/ml) had inferior recurrence free survival (RFS) than those with lower cfDNA concentrations (pre-operative period: median RFS: 30(3-60) months versus 60(6-60) months (p<0.0001), post-operative period: median RFS: 24(3-60) months versus 60(6-60) months (p<0.0001). Multivariate Cox regression analysis showed that post op cfDNA concentration (p=0.017), subtypes (p=0.011) and tumour size (p=0.006) were negative prognostic factor for RFS in the pre-operative period and post-operative period.Conclusion: Our study demonstrated the prognostic ability of perioperative cfDNA concentrations in breast cancer patients. Further, prospective studies are warranted to validate its clinical utility in breast cancer.
Feature-Level Fusion of Infrared Image and Visible Light Image Based on Two-Dimensional Discrete Wavelet Transform and High-Pass Filtering
Authors: Ren Zhigang , Ren Guoquan 
Published: November 2021

Abstract
Visible light images and infrared images can effectively complement each other in visual information. Effective fusion of infrared images and visible light images can not only provide better visual effects, but also provide more visual information. In this paper, the discrete cosine wavelet transform is used to obtain the basic information of the image, and the high-pass filter is used to obtain the characteristic information of the image, and the basic information and the characteristic information are effectively fused. In this paper, two-level discrete cosine wavelet transform is performed on the image, which can effectively extract features without distorting the image; secondly, use image quantization to encode, compress and decode the image, reduce the amount of image data, increase the computing speed, and be effective Perform fusion operations on color images. A representative image evaluation method is used to evaluate the fusion image, and the effectiveness of the proposed method is discussed. Experiments have proved that this method is more effective than other methods, and the effect is more obvious in the fusion of color images and infrared images.