bluuebunny/crossref_metadata_2025_split huggingface dataset:
ADP/ATP translocase 1 protects against an α-synuclein-associated neuronal cell damage in Parkinson’s disease model
Authors: Ding Wenyong , Qi Minghua , Ma Li , Xu Xuefei , Chen Yingfei , Zhang Wenli 
Published: July 2021

Abstract
Background
ADP/ATP translocase 1 (ANT1) is involved in the exchange of cytosolic ADP and mitochondrial ATP, and its defection plays an important role in mitochondrial pathogenesis. To reveal an etiological implication of ANT1 for Parkinson’s disease (PD), a neurodegenerative disorder, a mouse model treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine and neuroblastoma cell model induced by 1-methyl-4-pehny1-pyridine were utilized in this study.

Results
The tissue-specific abundance in ANT1 in mouse brains was accessed using the analysis of Western blot and immunohistochemistry. Down-regulated soluble ANT1 was found to be correlated with PD, and ANT1 was associated with PD pathogenesis via forming protein aggregates with α-synuclein. This finding was confirmed at cellular level using neuroblastoma cell models. ANT1 supplement in neuronal cells revealed the protective roles of ANT1 against cytotoxicity caused by MPP+. Protein interaction assay, coupled with the analysis of LC-MS/MS, silver-stained SDS-PAGE and Western blot against anti-ANT1 antibody respectively, illustrated the interaction of ANT1 with α-synuclein using the expressed α-synuclein as a bite. Additionally, a significant increasing ROSs was detected in the MPP+-treated cells.

Conclusions
This study indicated that ANT1 was a potentially causative factor of PD, and led to neuropathogenic injury via promoting the formation of protein aggregates with α-synuclein. This investigation potentially promotes an innovative understanding of ANT1 on the etiology of PD and provides valuable information on developing potential drug targets in PD treatment or reliable biomarkers in PD prognostication.
A novel two-phase cycle algorithm for effective cyber intrusion detection in edge computing
Authors: Gong Yiguang , Liu Yunping , Yin Chuanyang 
Published: July 2021

AbstractEdge computing extends traditional cloud services to the edge of the network, closer to users, and is suitable for network services with low latency requirements. With the rise of edge computing, its security issues have also received increasing attention. In this paper, a novel two-phase cycle algorithm is proposed for effective cyber intrusion detection in edge computing based on a multi-objective genetic algorithm (MOGA) and modified back-propagation neural network (MBPNN), namely TPC-MOGA-MBPNN. In the first phase, the MOGA is employed to build a multi-objective optimization model that tries to find the Pareto optimal parameter set for MBPNN. The Pareto optimal parameter set is applied for simultaneous minimization of the average false positive rate (Avg FPR), mean squared error (MSE) and negative average true positive rate (Avg TPR) in the dataset. In the second phase, some MBPNNs are created based on the parameter set obtained by MOGA and are trained to search for a more optimal parameter set locally. The parameter set obtained in the second phase is used as the input of the first phase, and the training process is repeated until the termination criteria are reached. A benchmark dataset, KDD cup 1999, is used to demonstrate and validate the performance of the proposed approach for intrusion detection. The proposed approach can discover a pool of MBPNN-based solutions. Combining these MBPNN solutions can significantly improve detection performance, and a GA is used to find the optimal MBPNN combination. The results show that the proposed approach achieves an accuracy of 98.81% and a detection rate of 98.23% and outperform most systems of previous works found in the literature. In addition, the proposed approach is a generalized classification approach that is applicable to the problem of any field having multiple conflicting objectives.
School-based interventions targeting double burden of malnutrition and educational outcomes of adolescents in low- and middle-income countries: protocol for a systematic review
Authors: Shinde Sachin , Wang Dongqing , Fawzi Wafaie W 
Published: July 2021

Abstract
Background
Adolescence is a period of rapid physical growth and transition between childhood to adulthood. However, in many developing countries, nutritional and epidemiological transitions are contributing to surging overnutrition, which, together with prevalent undernutrition, is resulting in the double burden of malnutrition (DBM) among adolescents. Schools as social systems have tremendous but mostly underutilized capacity to facilitate change and address a range of nutritional and associated educational concerns of adolescents and young people. The main objective of this systematic review will be to describe school-based interventions that address the multiple forms of malnutrition, and synthesize their effects on nutrition and educational outcomes among adolescents (10 − 19 − years − old) from low- and middle-income countries (LMICs).

Methods
Comprehensive literature searches will be conducted in multiple electronic databases, including Medline (through PubMed), Embase, CENTRAL (through Cochrane Library), CINAHL, and Google Scholar. We will include randomized controlled trials (RCTs), non-RCTs including controlled before-after studies, examining the effects of nutrition interventions on nutrition and educational outcomes among adolescents in LMICs. Two reviewers will independently screen all citations and full-text articles and abstract data. The quality of the included studies will be assessed with the Cochrane Collaboration’s revised tool for assessing the risk of bias for RCTs and the Risk Of Bias In Non-randomized Studies of Interventions tool for controlled before-after studies and non-randomized controlled trials.

Discussion
To maximize the power of schools as a platform to reinforce the mutually beneficial relationship between adolescent nutrition and education, it is imperative to develop and implement integrated interventions connecting schools, adolescents, parents, communities, and the health care system. The results of this systematic review may provide a comprehensive state of current knowledge on the effectiveness of school-based interventions to enable future research that maximizes the impact and efficiency of integrated approaches to tackle multiple forms of malnutrition among school-going and out-of-school adolescents.

Systematic review registration
PROSPERO ID: CRD42020211109
Some new formulas of complete and incomplete degenerate Bell polynomials
Authors: Kim Dae San , Kim Taekyun , Lee Si-Hyeon , Park Jin-Woo 
Published: July 2021

AbstractThe aim of this paper is to study the complete and incomplete degenerate Bell polynomials, which are degenerate versions of the complete and incomplete Bell polynomials, and to derive some properties and identities for those polynomials. In particular, we introduce some new polynomials associated with the incomplete degenerate Bell polynomials. In fact, they are the coefficients of the reciprocal of the power series given by 1 plus the one appearing as the exponent of the generating function of the complete degenerate Bell polynomials.
Common fixed point theorem on Proinov type mappings via simulation function
Authors: Alqahtani Badr , Alzaid Sara Salem , Fulga Andreea , Yeşilkaya Seher Sultan 
Published: July 2021

AbstractIn this paper, we aim to discuss the common fixed point of Proinov type mapping via simulation function. The presented results not only generalize, but also unify the corresponding results in this direction. We also consider an example to indicate the validity of the obtained results.
Exploring internal business factors and their impact on firm performance: small business perspective in Ethiopia
Authors: Engidaw Abriham Ebabu 
Published: July 2021

AbstractMainly, the study is aimed at exploring the internal business factors and their impact on firm performance in micro- and small-scale enterprises. The study employed a descriptive and explanatory research design and used a quantitative research approach. The study is conducted on Amhara region, North Wollo zone, Lalibela city administration micro- and small-scale enterprise operators, and in this study, the dependent variable is the performance of SMEs while independent variables are managerial factors, workplace factors, and entrepreneurial factors. To achieve the objectives of the study, 199 sample micro and small enterprises are selected from the 395 target populations. It used an explanatory design with stratified and simple random sampling techniques. The study employed descriptive and inferential statistical data analysis methods. The finding shows that the independent variables managerial factors and workplace-related factors have a positive and significant effect on small business performance in the study area. Also, there is an insignificant relationship between entrepreneurial factors and the dependent variable.
Function and clinical significance of N6-methyladenosine in digestive system tumours
Authors: Huang Junchao , Shao Yingjie , Gu Wendong 
Published: July 2021

AbstractRNA modification, like DNA methylation, histone modification, non-coding RNA modification and chromatin rearrangement, plays an important role in tumours. N6-methyladenosine (m6A) is the most abundant RNA modification in cells, and it regulates RNA transcription, processing, splicing, degradation, and translation. m6A-associated proteins have been used as new biomarkers and therapeutic targets for tumour prediction and monitoring. There are three main types of proteins involved in m6A methylation: methyltransferases (METTL3, METTL14, WTAP, RBM15, ZC3H13 and KIAA1429), demethylases (FTO, ALKBH5 and ALKBH3) and RNA-binding proteins (YTHDF1-3, YTHDC1-2, IGF2BPs and HNRNPs). This article reviews the origins, characteristics and functions of m6A and its relationship with digestive system tumours based on recent research. The expression of m6A regulators can be used as an evaluation indicator of tumour growth and progression and as a prognostic indicator. In-depth research on m6A methylation in digestive system tumours may provide new directions for clinical prediction and further treatment.
Understanding the experiences of hikikomori through the lens of the CHIME framework: connectedness, hope and optimism, identity, meaning in life, and empowerment; systematic review
Authors: Yung Jolene Y. K. , Wong Victor , Ho Grace W. K. , Molassiotis Alex 
Published: July 2021

Abstract
Background
Hikikomori is a phenomenon describing people who exhibit behaviors of self-secluding themselves at home for long durations of time and usually only having face-to-face social interactions with none other than family. Existing interventions for hikikomori are inconclusive and the majority are absent in using a theoretical framework to guide its components. Therefore, applicability of the psychosocial recovery framework of Connectedness, Hope and Optimism, Identity, Meaning in Life, and Empowerment (CHIME) towards hikikomori care was reviewed.

Method
Five databases were searched in April 2020 with the search formula from a published systematic review on hikikomori combined with search terms specific to domains of the CHIME framework. Articles included in the review were of the English language, of all publication years, peer-reviewed, quantitative or qualitative research studies and case studies, included study designs that were observational or interventional in nature, and involved populations of socially withdrawn youth.

Results
CHIME’s comprehensive structure and organized approach could guide researchers or service providers in determining areas needing assessments, measurement, and areas of focus. It is suggested that the CHIME framework is applicable after modifying a specific dimension—‘meaning of mental illness experiences’ into ‘meaning of the hikikomori experience’. Thematic overlap occurred between the domains of connectedness, identity, and meaning. Yet, additional dimensions or domains such as trust building, non-linearity, and spatiality can be included for addressing specific limitations in this application, which would help towards catering services to help hikikomori in recovery or in increasing quality-of-life of those individuals’ while entrapped in this withdrawn lifestyle.

Conclusion
CHIME framework could be applicable towards hikikomori care after applying the suggested modifications. Additionally, many knowledge gaps were found in literature during this review that warrants further investigation to improve hikikomori care.
Assessment of paradoxical anterior translation in a CR total knee prosthesis coupling dynamic RSA and FE techniques
Authors: Mirulla Agostino Igor , Bragonzoni Laura , Zaffagnini Stefano , Ingrassia Tommaso , Zinno Raffaele , Innocenti Bernardo 
Published: July 2021

Abstract
Purpose
The study aims were to assess the kinematic data, Internal-External (IE) rotation, and Antero-Posterior (AP) translation of the contact points between the femoral condyles and polyethylene insert and to develop a combined dynamic RSA-FE (Radiostereometric – Finite Element) model that gives results congruent with the literature.

Methods
A cohort of 15 patients who underwent cemented cruciate-retaining highly congruent mobile-bearing total knee arthroplasty were analyzed during a sit-to-stand motor task. The kinematical data from Dynamic RSA were used as input for a patient-specific FE model to calculate condylar contact points between the femoral component and polyethylene insert.

Results
The femoral component showed an overall range about 4 mm of AP translation during the whole motor task, and the majority of the movement was after 40° of flexion. Concerning the IE rotation, the femoral component started from an externally rotate position (− 6.7 ± 10°) at 80° of flexion and performed an internal rotation during the entire motor task. The overall range of the IE rotation was 8.2°.

Conclusions
During the sit to stand, a slight anterior translation from 40° to 0° of flexion of the femoral component with respect to polyethylene insert, which could represent a paradoxical anterior translation. Despite a paradoxical anterior femoral translation was detected, the implants were found to be stable. Dynamic RSA and FE combined technique could provide information about prosthetic component’s stress and strain distribution and the influence of the different designs during the movement.
Production of spiculisporic acid by Talaromyces trachyspermus in fed-batch bioreactor culture
Authors: Moriwaki-Takano Maki , Asada Chikako , Nakamura Yoshitosi 
Published: July 2021

AbstractSpiculisporic acid (SA) is a fatty acid-type biosurfactant with one lactone ring and two carboxyl groups. It has been used in metal removers and cosmetics, because of its low propensity to cause irritation to the skin, its anti-bacterial properties, and high surface activity. In the present study, we report an effective method for producing SA by selecting a high-producing strain and investigating the effective medium components, conditions, and environments for its culture. Among the 11 kinds of Talaromyces species, T. trachyspermus NBRC 32238 showed the highest production of a crystalline substance, which was determined to be SA using NMR. The strain was able to produce SA under acidic conditions from hexoses, pentoses, and disaccharides, with glucose and sucrose serving as the most appropriate substrates. Investigation of nitrogen sources and trace metal ions revealed meat extract and FeCl3 as components that promoted SA production. Upon comparing the two types of cultures with glucose in a baffle flask or aeration bioreactor, SA production was found to be slightly higher in the flask than in the reactor. In the bioreactor culture, sucrose was found to be an appropriate substrate for SA production, as compared to glucose, because with sucrose, the lag time until the start of SA production was shortened. Finally, fed-batch culture with sucrose resulted in 60 g/L of SA, with a total yield of 0.22 g SA/g sucrose and a productivity of 6.6 g/L/day.
Anesthetic management of multiple acyl-coenzyme A dehydrogenase deficiency in a series of surgeries under general anesthesia: a case report
Authors: Owaki-Nakano Ryoko , Higashi Midoriko , Iwashita Kohei , Shigematsu Kenji , Toyama Emiko , Yamaura Ken 
Published: July 2021

Abstract
Background
Glutaric acidemia is a type of multiple acyl-coenzyme A dehydrogenase deficiency, an inborn error in fatty acid metabolism. In patients with glutaric acidemia, during the perioperative period, prolonged fasting, stress, and pain have been identified as risk factors for the induction of metabolic derangement. This report describes the surgical and anesthetic management of a patient with glutaric acidemia.

Case presentation
A 56-year-old male patient with glutaric acidemia type 2 underwent a series of surgeries. During the initial off-pump coronary artery bypass surgery, the patient developed renal failure due to rhabdomyolysis upon receiving glucose at 2 mg/kg/min. However, in the second laparoscopic cholecystectomy, rhabdomyolysis was avoided by administering glucose at 4 mg/kg/min.

Conclusions
To avoid catabolism in patients with glutaric acidemia, appropriate glucose administration is important, depending on the surgical risk.
Binary defocusing technique based on complementary decoding with unconstrained dual projectors
Authors: Li Xuexing , Zhang Wenhui 
Published: July 2021

AbstractBinary defocusing technique can effectively break the limitation of hardware speed, which has been widely used in the real-time three-dimensional (3D) reconstruction. In addition, fusion technique can reduce captured images count for a 3D scene, which helps to improve real-time performance. Unfortunately, it is difficult for binary defocusing technique and fusion technique working simultaneously. To this end, our research established a novel system framework consisting of dual projectors and a camera, where the position and posture of the dual projectors are not strictly required. And, the dual projectors can adjust defocusing level independently. Based on this, this paper proposed a complementary decoding method with unconstrained dual projectors. The core idea is that low-resolution information is employed for high-resolution phase unwrapping. For this purpose, we developed the low-resolution depth extraction strategy based on periodic space-time coding patterns and the method from the low-resolution order to high-resolution order of fringe. Finally, experimental results demonstrated the performance of our proposed method, and the proposed method only requires three images for a 3D scene, as well as has strong robustness, expansibility, and implementation.
Pengurangan Subsidi BBM dan Polusi Udara Melalui Kebijakan Program Konversi dari BBM ke BBG Untuk Kendaraan di Propinsi Jawa Barat
Authors: Susanti Vita , Hartanto Agus , Subekti Ridwan Arief , Saputra Hendri Maja , Rijanto Estiko , Hapid Abdul 
Published: July 2021

The number of vehicle that use oil (BBM) is increasing every year in Indonesia while national oil reserve become smaller, so that the oil should be imported. The impact of using oil are increasing subsidy and air pollution. Thus, it is now becoming important to replace oil with another environmentally friendly energy, one of them is gas (BBG). Based on the number of vehicle and infrastructure in gas pipeline, part of northern West Java potentially can be chosen for the implementation of conversion program to gas (BBG). The number of vehicle in potential regions such as Depok, Cibinong, Bogor, Bekasi, Cikarang, Karawang, Purwakarta, Cirebon, and Bandung are around 875,505 units. From these data, we simulated the potential profit to be gained each year by converting 10% for the first year and increasing it to 5% for every year. By investing 3.16 trillion for conversion, 14.9 trillion can be achieved in the form of fuel subsidy savings. In addition, emission reduction converted to a CDM (clean development mechanism) can become local revenues. Total CDM generated during 5 years predicted is of U.S $ 772,385. From this study, it can be concluded that converting oil (BBM) to gas (BBG) is highly beneficial.
Digital literacy status of academic staff in the light of transformation in information and communication technologies
Authors: Işık Burçin , Özdemir Nurgül , Kuşlu Sebahat 
Published: July 2021

Objective: This study was planned to determine the digital literacy levels of faculty members and the factors affecting them in the light of the transformations in information and communication technologies and to create a resource for related studies.
Method: This cross-sectional and descriptive study was carried out in 2018 with 272 lecturers working at a state university. Personal Information Form and Digital Literacy Scale were used in data collection. Research data were analyzed in SPSS 22.0 package program. The data were analyzed using frequency, percentage, t test, Kolmogorov Smirnov, Mann-Whitney U and Kruskal Wallis test, and the results were evaluated at 95% confidence interval and p <0.05 significance level.
Findings: The research results show that the digital literacy levels of the lecturers are very high, age, gender, academic title, study year affect the digital literacy level, the lecturers use digital technologies such as computers and projectors in educational activities to a large extent.
Conclusion: In line with these results, it should be ensured that education activities related to digital literacy skills should be organized within the scope of continuous education activities in higher education institutions, and especially and primarily, it should be ensured that academic staff and female instructors in the advanced age group participate in digital literacy training.
​Extended English summary is in the end of Full Text PDF (TURKISH) file.

Özet
Amaç: Bu çalışma, bilgi ve iletişim teknolojilerindeki dönüşümler ışığında öğretim elemanlarının dijital okuryazarlık düzeylerini ve etkileyen faktörleri belirlemek ve ilgili çalışmalara kaynak oluşturmak amacıyla planlanmıştır.
Yöntem: Kesitsel ve tanımlayıcı olarak tasarlanmış bu çalışma, 2018’de bir devlet üniversitesinde çalışan 272 öğretim elemanı ile gerçekleştirilmiştir. Veri toplamada, Kişisel Bilgi Formu ve Dijital Okuryazarlık Ölçeği kullanılmıştır. Araştırma verileri SPSS 22.0 paket programında analiz edilmiştir. Veriler, frekans, yüzdelik, t testi, Kolmogorov Smirnov, Mann-Whitney U ve Kruskal Wallis testi kullanılarak analiz edilmiş olup, sonuçlar %95 güven aralığında, anlamlılık p<0.05 düzeyinde değerlendirilmiştir.
Bulgular: Araştırma sonuçları, öğretim elemanlarının dijital okuryazarlık düzeylerinin çok yüksek olduğunu, yaş, cinsiyet, akademik ünvan, çalışma yılının dijital okuryazarlık düzeyini etkilediğini, öğretim elemanlarının bilgisayar ve projeksiyon gibi dijital teknolojileri eğitim etkinliklerinde büyük oranda kullandıklarını göstermektedir.
Sonuç: Bu sonuçlar doğrultusunda, Yükseköğretim kurumlarında sürekli eğitim etkinlikleri kapsamında dijital okuryazarlık becerilerine ilişkin eğitim etkinlikleri düzenlenmesi, özellikle ve öncelikle, ileri yaş grubunda yer alan öğretim elemanlarının ve kadın öğretim elemanlarının dijital okuryazarlık eğitimlerine öncelikle katılmaları sağlanmalıdır.