bluuebunny/crossref_metadata_2025_split huggingface dataset:
Host‐Guest Complexation Between Cyclodextrins and Hybrid Hexavanadates: What are the Driving Forces?
Authors: Fa Bamba Ibrahima , Falaise Clément , Marrot Jérôme , Atheba Patrick , Gbassi Gildas , Landy David , Shepard William , Haouas Mohamed , Cadot Emmanuel 
Published: September 2021

AbstractHost‐guest complexes between native cyclodextrins (α‐, β‐ and γ‐CD) and hybrid Lindqvist‐type polyoxovanadates (POVs) [V6O13((OCH2)3C−R)2]2– with R = CH2CH3, NO2, CH2OH and NH(BOC) (BOC = N‐tert‐butoxycarbonyl) were studied in aqueous solution. Six crystal structures determined by single‐crystal X‐ray diffraction analysis revealed the nature of the functional R group strongly influences the host–guest conformation and also the crystal packing. In all systems isolated in the solid‐state, the organic groups R are embedded within the cyclodextrin cavities, involving only a few weak supramolecular contacts. The interaction between hybrid POVs and the macrocyclic organic hosts have been deeply studied in solution using ITC, cyclic voltammetry and NMR methods (1D 1H NMR, and 2D DOSY, and ROESY). This set of complementary techniques provides clear insights about the strength of interactions and the binding host‐guest modes occurring in aqueous solution, highlighting a dramatic influence of the functional group R on the supramolecular properties of the hexavanadate polyoxoanions (association constant K1:1 vary from 0 to 2 000 M−1) while isolated functional organic groups exhibit only very weak intrinsic affinity with CDs. Electrochemical and calorimetric investigations suggest that the driving force of the host‐guest association involving larger CDs (β‐ and γ‐CD) is mainly related to the chaotropic effect. In contrast, the hydrophobic effect supported by weak attractive forces appears as the main contributor for the formation of α‐CD‐containing host‐guest complexes. In any cases, the origin of driving forces is clearly related to the ability of the macrocyclic host to desolvate the exposed moieties of the hybrid POVs.
Formation and Stabilization of Vaterite Aggregate Grooves with Aspartic Acid (Asp) by Bubbling CO2 into a Ca(OH)2 Suspension
Authors: Zheng Tianwen , Yi Haihe 
Published: September 2021

AbstractVaterite aggregate grooves are successfully obtained by the Ca(OH)2‐CO2 reaction system in the presence of aspartic acid (Asp). Then, the dynamic changes of pH, conductivity, the concentration of Ca2+ and OH– in the suspension during the reaction process are tested. Moreover, the morphologies and polymorphs of the precipitates at different reaction time are studied by the field emission scanning electron microscope (FE‐SEM) and X‐ray Diffraction (XRD). The results show that when Asp is not added in the Ca(OH)2 suspension, the precipitates are calcite, while the carbonization precipitates with Asp are vaterite. Furthermore, in the presence of Asp, the carbonization process in the Ca(OH)2 suspension has a coating‐fragmentation behavior, and vaterite aggregate grooves can be formed after 110 min. In particular, Asp plays an important role in the nucleation, crystallization, and growth of CaCO3, and then a novel formation mechanism of vaterite aggregate grooves is proposed in this paper.
Selenium sulfide disrupts the PLAGL2/C‐MET/STAT3‐induced resistance against mitochondrial apoptosis in hepatocellular carcinoma
Authors: Yang Tianfeng , Huo Jian , Xu Rui , Su Qi , Tang Wenjuan , Zhang Dongdong , Zhu Man , Zhan Yingzhuan , Dai Bingling , Zhang Yanmin 
Published: September 2021

AbstractBackgroundHepatocellular carcinoma (HCC) is the third leading cause of cancer‐related deaths worldwide. Overexpression of pleomorphic adenoma gene like‐2 (PLAGL2) is associated with tumorigenesis. However, its function in HCC is unclear, and there are currently no anti‐HCC drugs that target PLAGL2. Drug repositioning may facilitate the development of PLAGL2‐targeted drug candidates.MethodsThe expression of PLAGL2 in HCC clinical tissue samples and HCC cell lines was analyzed by western blotting. The constructed HCC cell models were used to confirm the underlying function of PLAGL2 as a therapeutic target. Multiple in vitro and in vivo assays were conducted to determine the anti‐proliferative and apoptosis‐inducing effects of selenium sulfide (SeS2), which is clinically used for the treatment of seborrheic dermatitis and tinea versicolor.ResultsPLAGL2 expression was higher in HCC tumor tissues than in normal adjacent tissues. Its overexpression promoted the resistance of HCC cells of mitochondrial apoptosis through the regulation of the downstream C‐MET/STAT3 signaling axis. SeS2 exerted significant anti‐proliferative and apoptosis‐inducing effects on HCC cells in a PLAGL2‐dependent manner. Mechanistically, SeS2 suppressed C‐MET/STAT3, AKT/mTOR, and MAPK signaling and triggered Bcl‐2/Cyto C/Caspase‐mediated intrinsic mitochondrial apoptosis both in vitro and in vivo.ConclusionsOur data reveal an important role of PLAGL2 in apoptosis resistance in HCC and highlight the potential of using SeS2 as a PLAGL2 inhibitor in patients with HCC.
Residential yard management and landscape cover affect urban bird community diversity across the continental USA
Authors: Lerman Susannah B. , Narango Desirée L. , Avolio Meghan L. , Bratt Anika R. , Engebretson Jesse M. , Groffman Peter M. , Hall Sharon J. , Heffernan James B. , Hobbie Sarah E. , Larson Kelli L. , Locke Dexter H. , Neill Christopher , Nelson Kristen C. , Padullés Cubino Josep , Trammell Tara L. E. 
Published: September 2021

AbstractUrbanization has a homogenizing effect on biodiversity and leads to communities with fewer native species and lower conservation value. However, few studies have explored whether or how land management by urban residents can ameliorate the deleterious effects of this homogenization on species composition. We tested the effects of local (land management) and neighborhood‐scale (impervious surface and tree canopy cover) features on breeding bird diversity in six US metropolitan areas that differ in regional species pools and climate. We used a Bayesian multiregion community model to assess differences in species richness, functional guild richness, community turnover, population vulnerability, and public interest in each bird community in six land management types: two natural area park types (separate and adjacent to residential areas), two yard types with conservation features (wildlife‐certified and water conservation) and two lawn‐dominated yard types (high‐ and low‐fertilizer application), and surrounding neighborhood‐scale features. Species richness was higher in yards compared with parks; however, parks supported communities with high conservation scores while yards supported species of high public interest. Bird communities in all land management types were composed of primarily native species. Within yard types, species richness was strongly and positively associated with neighborhood‐scale tree canopy cover and negatively associated with impervious surface. At a continental scale, community turnover between cities was lowest in yards and highest in parks. Within cities, however, turnover was lowest in high‐fertilizer yards and highest in wildlife‐certified yards and parks. Our results demonstrate that, across regions, preserving natural areas, minimizing impervious surfaces and increasing tree canopy are essential strategies to conserve regionally important species. However, yards, especially those managed for wildlife support diverse, heterogeneous bird communities with high public interest and potential to support species of conservation concern. Management approaches that include the preservation of protected parks, encourage wildlife‐friendly yards and acknowledge how public interest in local birds can advance successful conservation in American residential landscapes.
Favoring recruitment as a conservation strategy to improve the resilience of long‐lived reptile populations: Insights from a population viability analysis
Authors: Warret Rodrigues Chloé , Angin Baptiste , Besnard Aurélien 
Published: September 2021

AbstractIn long‐lived species, although adult survival typically has the highest elasticity, temporal variations in less canalized demographic parameters are the main drivers of population dynamics. Targeting recruitment rates may thus be the most effective strategy to manage these species. We analyzed 1,136 capture–recapture histories collected over 9 years in an isolated population of the critically endangered Lesser Antillean iguana, using a robust design Pradel model to estimate adult survival and recruitment rates. From an adult population size estimated at 928 in 2013, we found a yearly decline of 4% over the 8‐year period. As expected under the canalization hypothesis for a long‐lived species, adult survival was high and constant, with little possibility for improvement, whereas the recruitment rate varied over time and likely drove the observed population decline. We then used a prospective perturbation analysis to explore whether managing the species’ immature cohorts would at least slow the population decline. The prospective perturbation analysis suggested that a significant and sustained conservation effort would be needed to achieve a recruitment rate high enough to slow the population decline. We posit that the high recruitment rate achieved in 2014—likely due to the maintenance in 2012 of the main nesting sites used by this population—would be sufficient to slow this population's decline if it was sustained each year. Based on the results of diverse pilot studies we conducted, we identified the most likely threats targeting the eggs and immature cohorts, stressing the need to improve reproductive success and survival of immature iguanas. The threats we identified are also involved in the decline of several reptile species, and species from other taxa such as ground‐nesting birds. These findings on a little‐studied taxon provide further evidence that focusing on the immature life stages of long‐lived species can be key to their conservation.
High genetic and epigenetic variation of transposable elements: Potential drivers to rapid adaptive evolution for the noxious invasive weed Mikania micrantha
Authors: Su Yingjuan , Huang Qiqi , Wang Zhen , Wang Ting 
Published: September 2021

AbstractWhy invasive species can rapidly adapt to novel environments is a puzzling question known as the genetic paradox of invasive species. This paradox is explainable in terms of transposable elements (TEs) activity, which are theorized to be powerful mutational forces to create genetic variation. Mikania micrantha, a noxious invasive weed, in this sense provides an excellent opportunity to test the explanation. The genetic and epigenetic variation of 21 invasive populations of M. micrantha in southern China have been examined by using transposon display (TD) and transposon methylation display (TMD) techniques to survey 12 TE superfamilies. Our results showed that M. micrantha populations maintained an almost equally high level of TE‐based genetic and epigenetic variation and they have been differentiated into subpopulations genetically and epigenetically. A similar positive spatial genetic and epigenetic structure pattern was observed within 300 m. Six and seven TE superfamilies presented significant genetic and epigenetic isolation by distance (IBD) pattern. In total, 59 genetic and 86 epigenetic adaptive TE loci were identified. Of them, 51 genetic and 44 epigenetic loci were found to correlate with 25 environmental variables (including precipitation, temperature, vegetation coverage, and soil metals). Twenty‐five transposon‐inserted genes were sequenced and homology‐based annotated, which are found to be involved in a variety of molecular and cellular functions. Our research consolidates the importance of TE‐associated genetic and epigenetic variation in the rapid adaptation and invasion of M. micrantha.
Heart Failure Association of the European Society of Cardiology position paper on the management of left ventricular assist device‐supported patients for the non‐left ventricular assist device specialist healthcare provider: Part 2: at the emergency department
Authors: Milicic Davor , Ben Avraham Binyamin , Chioncel Ovidiu , Barac Yaron D. , Goncalvesova Eva , Grupper Avishai , Altenberger Johann , Frigeiro Maria , Ristic Arsen , De Jonge Nicolaas , Tsui Steven , Lavee Jacob , Rosano Giuseppe , Crespo‐Leiro Marisa Generosa , Coats Andrew J.S. , Seferovic Petar , Ruschitzka Frank , Metra Marco , Anker Stefan , Filippatos Gerasimos , Adamopoulos Stamatis , Abuhazira Miriam , Elliston Jeremy , Gotsman Israel , Hamdan Righab , Hammer Yoav , Hasin Tal , Hill Lorrena , Itzhaki Ben Zadok Osnat , Mullens Wilfried , Nalbantgil Sanemn , Piepoli Massimo Francesco , Ponikowski Piotr , Potena Luciano , Ruhparwar Arjang , Shaul Aviv , Tops Laurens F. , Winnik Stephan , Jaarsma Tiny , Gustafsson Finn , Ben Gal Tuvia 
Published: September 2021

AbstractThe improvement in left ventricular assist device (LVAD) technology and scarcity of donor hearts have increased dramatically the population of the LVAD‐supported patients and the probability of those patients to present to the emergency department with expected and non‐expected device‐related and patient–device interaction complications. The ageing of the LVAD‐supported patients, mainly those supported with the ‘destination therapy’ indication, increases the risk for those patients to suffer from other co‐morbidities common in the older population. In this second part of the trilogy on the management of LVAD‐supported patients for the non‐LVAD specialist healthcare provider, definitions and structured approach to the LVAD‐supported patient presenting to the emergency department with bleeding, neurological event, pump thrombosis, chest pain, syncope, and other events are presented. The very challenging issue of declaring death in an LVAD‐supported patient, as the circulation is artificially preserved by the device despite no other signs of life, is also discussed in detail.
Depression mediates physical activity readiness and physical activity in patients with heart failure
Authors: Deka Pallav , Almenar Luis , Pathak Dola , Klompstra Leonie , López‐Vilella Raquel , Marques‐Sule Elena 
Published: September 2021

AbstractAimsAlthough physical activity (PA) and exercise are essential for patients with heart failure (HF), adherence to the recommended guidelines is low. Not much is known about the mediating effect of HF patients' mental state with their readiness for PA and reported activity levels. The purpose of this study is to investigate the mediatory effect of depression on PA readiness (physical limitation and psychological readiness) and self‐reported PA in patients with HF.Methods and resultsIn this cross‐sectional study, 163 New York Heart Association Class I and II HF patients, during their clinic visit, reported on their physical limitation (PAR‐Q) and psychological readiness [self‐efficacy (ESES) and motivation (RM 4‐FM)] for PA, depression (HADS‐D), and PA (s‐IPAQ). Mediation analysis was performed to test the mediating effect of depression on PA readiness (physical limitation and psychological readiness) and self‐reported PA following the steps described by Baron and Kenny (1986). Hierarchical regression models were tested for their effects. The Self‐Efficacy Theory and Self‐Determination theory provided the theoretical platform for the study. Depression completely mediated the effect of physical limitation (βdep = 268.57; P < 0.0001) and partially mediated the effect of self‐efficacy on PA (βdep = 344.16; P < 0.0001). Both intrinsic (P < .0001) and extrinsic motivation (P < .0001) for PA had an independent and significant effect on PA, not mediated by depression.ConclusionsPatients with HF should be screened for depression throughout the trajectory of the disease as it can impact their physical and psychological readiness to perform PA.
Lanthanide‐Based Metal‐Organic‐Frameworks for Proton Conduction and Magnetic Properties
Authors: Biswas Soumava , Neugebauer Petr 
Published: September 2021

AbstractThe coexistence of proton conductivity and magnetic properties in metal organic frameworks (MOFs) is simply an attractive prospect to design and create multifunctional molecular materials. However, the simultaneity of interesting magnetic properties (e.g. magnetocaloric effect, slow magnetic relaxation or magnetic ordering) and proton conduction in a MOF is very implausible to be observed, as chemical and structural necessities are absolutely poles apart for either of the properties. In this context, lanthanide‐based metal‐organic frameworks (LMOFs) have emerged as an intriguing class of materials to observe such coexistence in few cases. In this perspective, the advantages of combining lanthanide ions and organic acids as ligands to construct a proton‐conductive magnetic metal organic framework are briefly discussed. The current status of this specific research area regarding some fascinating LMOFs exhibiting proton conductivity and magnetic properties is reviewed in detail. Also, a future perspective of such materials is discussed.
A Continuous‐Flow Route to Enantioenriched 3‐Substituted‐3‐Hydroxyoxindoles: Organocatalytic Aldol Reactions of Isatin with Acetone
Authors: Tseke Kavnen , Lennon Claire , O'Mahony Joseph , Kinsella Michael 
Published: September 2021

AbstractAn efficient L‐leucinol catalysed asymmetric synthesis of 3‐substitued‐3‐hydroxyoxindoles was for the first time completed under continuous flow, providing a safer route for accelerating the reaction at higher temperatures without adversely affecting enantioselectivity. Initial batch solvent screening of the isatin‐acetone aldol reaction revealed neat acetone as the media best suited in flow as it dissolved isatin and afforded (S)‐enantiomer of the adduct in 84 % ee. Solvents with Kamlet‐Taft basicity (β)>0.6 and proticity (α)≈0 had a higher solubility of isatin but poor reaction performance while solvents with β<0.2 and α<0.6 performed excellently in the reaction albeit with poor isatin solubility. The addition of 10 equivalents of water improved the neat reaction to afford 94 % yield in 93 % ee at 20 °C after 48 h. When transferred to continuous flow, complete conversion was observed in 12 h residence time at 40 °C without loss in enantioselectivity. Further substrate studies in flow were undertaken with a 4‐fold dilution and a 60 °C reaction temperature required for some derivatives. Excellent yields and enantioselectivities were obtained in most cases.
Electricity Driven 1,3‐Oxohydroxylation of Donor‐Acceptor Cyclopropanes: a Mild and Straightforward Access to β‐Hydroxy Ketones
Authors: Saha Debarshi , Maajid Taily Irshad , Banerjee Prabal 
Published: September 2021

AbstractAn unprecedented external oxidant‐free electrochemical protocol for 1, 3‐oxohydroxylation of donor‐acceptor cyclopropane is disclosed. The strategy encompasses the activation of the labile π‐electron cloud of the aryl ring to cleave the strained Csp3−Csp3 bond of cyclopropane to afford the β‐hydroxy ketones via insertion of molecular oxygen. More significantly, based on the detailed mechanistic investigations and cyclic voltammetry experiments, a plausible mechanism is proposed.
A critical review on the fabrication techniques that can enable higher throughput in dielectrophoresis devices
Authors: Martinez‐Duarte Rodrigo 
Published: September 2021

AbstractThe sorting of targeted cells in a sample is a cornerstone of healthcare diagnostics and therapeutics. This work focuses on the use of dielectrophoresis for the selective sorting of targeted bioparticles in a sample and how the lack of throughput has been one important practical challenge to its widespread practical implementation. Increasing the cross‐sectional area of a channel can lead to higher flow rates and thus the capability to process a larger sample volume per unit of time. However, the required electric field gradient that is generated by polarized electrodes drastically decreases as one moves away from the electrodes. Hence, the scaling up of the channel cross section must be done asymmetrically. One desires a channel aspect ratio AR = height/width that is much smaller or much larger than 1. Since reducing footprint of the DEP device is important to ensure affordability, the use of channels with AR ≫ 1 is desired. This creates the challenge to fabricate electrodes on the sidewalls of multiple channels with AR ≫ 1, or a channel embedding an array of electrodes with a gap in between them with AR ≫ 1. This critical review first details the motivation for using three‐dimensional (3D) DEP devices to improve throughput and then describes selected techniques that have been used to fabricate them. Techniques include electrodeposition, deep etching, thick‐film photolithography, and co‐fabrication. Electrode materials addressed include metals, silicon, carbon, PDMS‐based composites as well as conductive polymers and fluids.
Availability‐guaranteeing maintenance of series machine tools
Authors: Praedicow Michael , Apitzsch René , Richter Anja , Wunderlich Tim , Klimant Philipp 
Published: September 2021

AbstractCondition monitoring enables transparency, as for example irregularities are detected automatically and reported. A condition forecast, however, requires more. In contrast to AI black box methods, frequently used in this context, a combination of existing expert knowledge and classical statistics is used as a method for a reliable determination of the remaining component‐lifetime. This works, if meaningful historical data are available in a sufficient quantity and quality. And this in turn requires a corresponding number of machines that are as identical in construction as possible and which must also be subject to a defined test regime, temporally closely monitored outside the production process. However, the quantity can be significantly smaller than the number of cases required for a prescient analysis of the correlations between a condition parameter and the wear condition of a specific component. The main target audience of the strategy presented here is therefore in particular manufacturers of series machines who wish to offer maintenance packages with corresponding availability guarantees and on‐site support for maintenance personnel.
Performance analyses of TAS/Alamouti‐MRC NOMA system with channel estimation error, feedback delay, and imperfect SIC
Authors: Toka Mesut , Kucur Oğuz 
Published: September 2021

AbstractIn this article, the performance of a power domain downlink multiple‐input multiple‐output non‐orthogonal multiple access system, where the base station (BS) equipped with three antennas communicates simultaneously with three mobile users equipped with multiple antennas, is analyzed over Nakagami‐mfading channels in the presence of channel estimation error (CEE), feedback delay (FBD), and imperfect successive interference cancellation. In the considered system, the BS applies transmit antenna selection (TAS)/Alamouti‐space‐time block coding (STBC) scheme while mobile users are assumed to adopt maximum‐ratio combining technique in order to take advantage of the combination of transmit and receive diversities. In particular, in order to apply Alamouti‐STBC scheme at the BS, one of the transmit antennas is determined randomly while the other one is selected according to decision of the majority of mobile users. For performance metrics, closed‐form outage probability (OP) and ergodic capacity (EC) expressions derived with the help of moment generating function approach. Moreover, asymptotic analyses are maintained to demonstrate the effects of CEE and FBD in terms of diversity order and array gain. We show that the proposed system provides better OP and EC performance than the system without antenna selection for different users and conditions.