bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypodopaminergic state of the nigrostriatal pathway drives compulsive alcohol use
Authors: Goutaudier Raphaël , Mallet David , Bartolomucci Magali , Guicherd Denis , Carcenac Carole , Vossier Frédérique , Dufourd Thibault , Boulet Sabrina , Deransart Colin , Chovelon Benoit , Carnicella Sebastien 
Published: December 2021

AbstractThe neurobiological mechanisms underlying compulsive alcohol use, a cardinal feature of alcohol use disorder, remain elusive. The key modulator of motivational processes dopamine (DA) is suspected to play an important role in this pathology, but its exact implication remains to be determined. Here, we found that rats expressing compulsive alcohol-related behavior, operationalized as punishment-resistant self-administration, showed a decrease in DA levels restricted to the dorsolateral territories of the striatum, the main output structure of the nigrostriatal DA pathway. We then causally demonstrated that a chemogenetic-induced selective hypodopaminergia of this pathway results in compulsive alcohol self-administration in rats otherwise resilient, accompanied by the emergence of alcohol withdrawal-like motivational impairments. These results demonstrate a major implication of tonic nigrostriatal hypodopaminergic state in alcohol addiction and provide new insights into our understanding of the neurobiological mechanisms underlying compulsive alcohol use.
New Insights into Molecular Basis Identification of Three Novel Strains of the Bacillus Subtilis Group Produce Cry Proteins Isolated from Soil Samples in Adana, Turkey
Authors: Yılmaz Semih , Idris Abeer Babiker , Ayvaz Abdurrahman , Çetin Aysun , Ülgen Funda , Çetin Mustafa , Saraymen Berkay , Hassan Mohamed A. 
Published: December 2021

AbstractAimsThis study aimed to analyze the evolutionary relationship betweenBacillusspecies isolated from agricultural soil using in-silico tools.Methods and ResultsAcross-sectional study was conducted in Adana province, in Turkey. A total of 120Bacillusspecies were isolated from 80 soil samples. However, the phylogenetic tree diverged into two lineages; one belongs toB. subtilisgroup while the other belongs toB. cereusgroup. Interestingly, three native strains (SY27.1A, SY35.3A, andSY58.5A), which produce Cry proteins, shared high similarity withB. subtilisgroup (over 99%) and less than 95% similarity with knownB. thuringiensisand other species ofB. cereusgroup. Furthermore, 11 canonical SNPs (canSNPs) were identified in strains that belong toB. pumilusgroup when compared withB. subtilisreference sequences.ConclusionsPhylogenetic analysis of16S rRNAsequences was found valuable for differentiation betweenBacillusspecies isolated from soil samples. In addition, SNPs analysis provided more intra-specific information in the cases ofB. subtilisgroup.Significance and Impact of StudyA detailed analysis was provided for the SNPs present in a conserved region of16S rRNAgene ofBacillusspecies. Also, we proposed three novelBacillusstrains that produce Cry proteins and belong toB. subtilisgroup.
Openness and technological innovation: the moderating effect of information technology adoption and political ties
Authors: Jiao Hao , Yang Jifeng , Jiang Cheng , Yu Jiawei 
Published: December 2021

PurposeThis research helps firms pursue an open innovation strategy but want to minimize competitive pressure from other external entities. A theoretical framework is constructed to analyze the impact of openness on innovation performance, exploring different effect of firms' external search channels.Design/methodology/approachThis paper employs a stepwise hierarchical regression approach to assess the effect of openness on technological innovation considering the role of information technology adoption and political ties. The effect is conducted using a large-scale sample of 1,073 Chinese manufacturing firms over the period 2011–2013 as empirical research objects.FindingsThere are two stages of the open technological innovation process while the information technology (IT) adoption and political ties are the key consideration in emerging markets. Openness is curvilinearly (taking an inverted U-shape) related to innovation performance. Both information technology adoption and political ties generally help firms to turn broadly sourced external knowledge into technological innovation performance. This will stimulate “one plus one is greater than two” effect not only in the process of achieving performance goals, but also in the process of technological innovation.Originality/valueThis quantitative research illustrates the importance relationship between firms' open behaviors and technological innovation performance in emerging markets. It helps us understand firms' current constrains of open strategy of technological innovation and helps domestic or foreign investors to make strategic collaboration choices in emerging economies according to the degree of openness, informatization level, political connections, which is equally important for research and practice.
Why companies succeed or fail: corporate cycles and firm function in tandem
Authors: Mourdoukoutas Panos , Stefanidis Abraham 
Published: December 2021

Purpose
This paper aims to underscore the need for developing a model of corporate cycles, which can explain how corporations rise, decline and fall in the marketplace.

Design/methodology/approach
This is a conceptual study that draws on prior theoretical and empirical insights of the entrepreneurial, managerial and social functions of the firm to develop a model of corporate cycles.

Findings
Firms that pass the test of the market and live for a long time, undergo cycles, expansions and contractions, driven by successes and failures in the way they configure and execute their entrepreneurial, managerial and social, functions.

Practical implications
A model of corporate cycles can explain how momentum rises and falls on Wall Street. It can also help predict revenue growth, a key variable in equity valuation models.

Originality/value
The originality of this study stems from a constructive synthesis of different concepts and theories of the firm to explain firms’ growth, decline and fall in the marketplace.
Smart, hybrid and context-aware POI mobile recommender system in tourism in Oman
Authors: Afsahhosseini Fatemehalsadat , Al-Mulla Yaseen 
Published: December 2021

PurposeThe purpose of this study is to identify the knowledge gap and future opportunities for developing mobile recommender system in tourism sector that lead to comfortable, targeted and attractive tourism. A recommender system improves the traditional classification algorithms and has incorporated many advanced machine learning algorithms.Design/methodology/approachDesign of this application followed a smart, hybrid and context-aware recommender system, which includes various recommender systems. With the recommender system's help, useful management for time and budget is obtained for tourists, since they usually have financial and time constraints for selecting the point of interests (POIs) and so more purposeful trip planned with decreased traffic and air pollution.FindingsThe finding of this research showed that the inclusion of additional information about the item, user, circumstances, objects or conditions and the environment could significantly impact recommendation quality and information and communications technology has become one part of the tourism value chain.Practical implicationsThe application consists of (1) registration: with/without social media accounts, (2) user information: country, gender, age and his/her specific interests, (3) context data: available time, alert, price, spend time, weather, location, transportation.Social implicationsThe study’s social implications include connecting the app and registration through social media to a more social relationship, with its textual reviews, or user review as user-generated content for increasing accuracy.Originality/valueThe originality of this research work lies on introducing a new content- and knowledge-based algorithm for POI recommendations. An “Alert” context emphasizing on safety, supplies and essential infrastructure is considered as a novel context for this application.
Fashion designers' attitude-behaviour inconsistencies towards a sustainable business model: a neutralisation theory perspective
Authors: Muposhi Asphat , Nyagadza Brighton , Mafini Chengedzai 
Published: December 2021

PurposeFashion designers in South Africa remain ambivalent in embracing sustainable fashion. This study examines the role of neutralisation techniques on attitude towards sustainable fashion. The study was conducted in South Africa, an emerging market known for water scarcity and pollution emanating from the textile industry.Design/methodology/approachA structured questionnaire was used to collect cross-sectional data from a sample of 590 fashion designers using a web-based online survey. Study constructs were drawn from the neutralisation theory and theory of planned behaviour.FindingsStandard multiple regression analysis results identified denial of injury, appeal to higher loyalties and external locus of control as the major rationalisation techniques influencing South African designers' negative attitudes towards sustainable fashion.Research limitations/implicationsResearch was conducted in South Africa where the concept of sustainable fashion is still at developmental stages. The generalisation of the study findings may be enhanced by extending the study to other markets with a fully developed market for sustainable fashion.Practical implicationsThe study results underscore the necessity of reducing social, structural and institutional barriers associated with the adoption of sustainable fashion. This study provides input towards efforts to develop attitude change strategies to stimulate designers to embrace sustainable fashion.Originality/valueThe research study contributes to theory, practice and future research.
A lack of mess? Advice on undertaking video-mediated participant observations
Authors: Høg Utoft Ea , Kusk Søndergaard Mie , Bendtsen Anna-Kathrine 
Published: December 2021

PurposeThis article offers practical advice to ethnographers venturing into doing participant observations through, but not about, videoconferencing applications such as Zoom, for which the methods literature offers little guidance.Design/methodology/approachThe article stems from a research project about a BioMedical Design Fellowship. As the COVID-19 pandemic hit, the Fellowship converted all teaching activities to online learning via Zoom, and the participant observations followed along. Taking an autoethnographic approach, the authors present and discuss concrete examples of encountered obstacles produced by the video-mediated format, such as limited access and interactions, technical glitches and changing experiences of embodiment.FindingsChanging embodiment in particular initially led the authors to believe that the “messiness” of ethnography (i.e. misunderstandings, emotions, politics, self-doubts etc.) was lost online. However, over time the authors realized that the mess was still there, albeit in new manifestations, because Zoom shaped the interactions of the people the authors observed, the observations the authors could make and how the authors related to research participants and vice versa.Practical implicationsThe article succinctly summarizes the key advice offered by the researchers (see Section 5) based on their experiences of converting on-site ethnographic observations into video-mediated observations enabling easy use by other researchers in relation to other projects and contexts.Originality/valueThe article positions video-mediated observations, via e.g. Zoom, which are distinctly characterised by happening in real time and having an object of study other than the online sphere itself, vis-à-vis other “online ethnography” methods. The article further aims to enable researchers to more rapidly rediscover and re-incite the new manifestations of the messiness of ethnography online, which is key to ensuring high-quality research.
The role of green process innovation translating green entrepreneurial orientation and proactive sustainability strategy into environmental performance
Authors: Frare Anderson Betti , Beuren Ilse Maria 
Published: December 2021

PurposeThis paper analyzes the mediating role of green process innovation in the relationships of green entrepreneurial orientation and proactive sustainability strategy with environmental performance.Design/methodology/approachThe authors analyze data from 81 Brazilian agriculture technology startups (AgTechs) using partial least squares–structural equation modeling (PLS-SEM) and fuzzy-set qualitative comparative analysis (fsQCA).FindingsThe results show that the green process innovation assumes an important role in AgTechs, promoting full mediations between green entrepreneurial orientation and proactive sustainability strategy with environmental performance. There are two ways for AgTechs to achieve high environmental performance. In both, green process innovation is a central condition, while green entrepreneurial orientation or proactive sustainability strategy is a complementary condition.Research limitations/implicationsThis study demonstrates how internal elements (green entrepreneurial orientation, proactive sustainability strategy and green process innovation) improve environmental performance. This answers calls to explore which elements translate green entrepreneurial orientation and proactive sustainability strategies into environmental performance, by highlighting the mediating role of green process innovation.Practical implicationsThe findings are useful for founders and managers of AgTechs to find ways to manage sustainable technological advancement and cleaner production in agribusiness.Originality/valueThis study analyses the interface between sustainable entrepreneurship, strategy and innovation in promoting environmental performance of AgTechs from an emerging economy country.
Vehicle routing problem for humanitarian relief distribution under hybrid uncertainty
Authors: Nodoust Sara , Pishvaee Mir Saman , Seyedhosseini Seyed Mohammad 
Published: December 2021

PurposeGiven the importance of estimating the demand for relief items in earthquake disaster, this research studies the complex nature of demand uncertainty in a vehicle routing problem in order to distribute first aid relief items in the post disaster phase, where routes are subject to disruption.Design/methodology/approachTo cope with such kind of uncertainty, the demand rate of relief items is considered as a random fuzzy variable and a robust scenario-based possibilistic-stochastic programming model is elaborated. The results are presented and reported on a real case study of earthquake, along with sensitivity analysis through some important parameters.FindingsThe results show that the demand satisfaction level in the proposed model is significantly higher than the traditional scenario-based stochastic programming model.Originality/valueIn reality, in the occurrence of a disaster, demand rate has a mixture nature of objective and subjective and should be represented through possibility and probability theories simultaneously. But so far, in studies related to this domain, demand parameter is not considered in hybrid uncertainty. The worth of considering hybrid uncertainty in this study is clarified by supplementing the contribution with presenting a robust possibilistic programming approach and disruption assumption on roads.
New perspectives of experiential tourism: an exploratory analysis of live virtual tours during the COVID-19 outbreak
Authors: Mastroberardino Piero , Calabrese Giuseppe , Cortese Flora , Petracca Miriam 
Published: December 2021

PurposeThis paper aims to find out if it is possible to consider live virtual tours, in the connotation assumed during the COVID-19 outbreak, as experiential tourism products. The paper focuses on Holbrook's “four Es” (“experience”, “entertainment”, “exhibitionism” and “evangelising”) to study the experience of live virtual tours.Design/methodology/approachThis article develops an exploratory analysis and presents a content analysis of 1052 reviews of 108 live virtual tours posted on TripAdvisor and Viator.FindingsThe findings show that live virtual tours are perceived as experiences, all “four Es” are covered and two more sub-categories emerge.Research limitations/implicationsThe analysis is limited to the perception of tourists that are confident with the technology, to a small sample and a period of travel restrictions due to the COVID-19 outbreak.Practical implicationsLive virtual tours create a new segment, which “travels from home”. This does not preclude tourists from deciding to physically visit the places seen virtually.Originality/valueResearch on the analysis of the reviews of live virtual tours has not yet been carried out.
Thermal tolerance in Drosophila: Repercussions for distribution, community coexistence and responses to climate change
Authors: Alruiz José M. , Peralta‐Maraver Ignacio , Bozinovic Francisco , Santos Mauro , Rezende Enrico L. 
Published: December 2021

Abstract

Here we combined controlled experiments and field surveys to determine if estimates of heat tolerance predict distributional ranges and phenology of different Drosophila species in southern South America.

We contrasted thermal death time curves, which consider both magnitude and duration of the challenge to estimate heat tolerance, against the thermal range where populations are viable based on field surveys in an 8‐year longitudinal study.

We observed a strong correspondence of the physiological limits, the thermal niche for population growth, and the geographic ranges across studied species, which suggests that the thermal biology of different species provides a common currency to understand how species will respond to warming temperatures both at a local level and throughout their distribution range.

Our approach represents a novel analytical toolbox to anticipate how natural communities of ectothermic organisms will respond to global warming.
The Lys‐motif receptor LYK4 mediates Enterobacter sp. SA187 triggered salt tolerance in Arabidopsis thaliana
Authors: Rolli Eleonora , de Zélicourt Axel , Alzubaidy Hanin , Karampelias Michael , Parween Sabiha , Rayapuram Naganand , Han Baoda , Froehlich Katja , Abulfaraj Aala A. , Alhoraibi Hanna , Mariappan Kiruthiga , Andrés‐Barrao Cristina , Colcombet Jean , Hirt Heribert 
Published: December 2021

SummaryRoot endophytes establish beneficial interactions with plants, improving holobiont resilience and fitness, but how plant immunity accommodates beneficial microbes is poorly understood. The multi‐stress tolerance‐inducing endophyte Enterobacter sp. SA187 triggers a canonical immune response in Arabidopsis only at high bacterial dosage (>108 CFUs ml−1), suggesting that SA187 is able to evade or suppress the plant defence system at lower titres. Although SA187 flagellin epitopes are recognized by the FLS2 receptor, SA187‐triggered salt tolerance functions independently of the FLS2 system. In contrast, overexpression of the chitin receptor components LYK4 and LYK5 compromised the beneficial effect of SA187 on Arabidopsis, while it was enhanced in lyk4 mutant plants. Transcriptome analysis revealed that the role of LYK4 is intertwined with a function in remodelling defence responses with growth and root developmental processes. LYK4 interferes with modification of plant ethylene homeostasis by Enterobacter SA187 to boost salt stress resistance. Collectively, these results contribute to unlock the crosstalk between components of the plant immune system and beneficial microbes and point to a new role for the Lys‐motif receptor LYK4 in beneficial plant–microbe interaction.
Anaerobic methane oxidation linked to Fe(III) reduction in a Candidatus Methanoperedens‐enriched consortium from the cold Zoige wetland at Tibetan Plateau
Authors: Chen Lin , Li Lingyan , Zhang Shengjie , Zhang Wenting , Xue Kai , Wang Yanfen , Dong Xiuzhu 
Published: December 2021

SummaryAnaerobic oxidation of methane (AOM) is a microbial process degrading ample methane in anoxic environments, and Ca. Methanoperedens mediated nitrate‐ or metal‐reduction linked AOM is believed important in freshwater systems. This work, via 16S rRNA gene diversity survey and 16S rRNA quantification, found abundant Ca. Methanoperedens along with iron in the cold Zoige wetland at Tibetan Plateau. The wetland soil microcosm performed Fe(III) reduction, rather than nitrate‐ nor sulphate‐reduction, coupled methane oxidation (3.87 μmol d−1) with 32.33 μmol Fe(II) accumulation per day at 18°C, but not at 30°C. A metagenome‐assembled genome (MAG) recovered from the microcosm exhibits ~74% average nucleotide identity with the reported Ca. Methanoperedens spp. that perform Fe(III) reduction linked AOM, thus a novel species Ca. Methanoperedens psychrophilus was proposed. Ca. M. psychrophilus contains the whole suite of CO2 reductive methanogenic genes presumably involving in AOM via a reverse direction, and comparative genome analysis revealed its unique gene categories: the multi‐heme clusters (MHCs) cytochromes, the S‐layer proteins highly homologous to those recovered from lower temperature environments and type IV pili, those could confer Ca. M. psychrophilus of cold adaptability. Therefore, this work reports the first methanotroph implementing AOM in an alpine wetland.
Equity Crowdfunding: The Influence of Perceived Innovativeness on Campaign Success
Authors: Le Pendeven Benjamin , Schwienbacher Armin 
Published: December 2021

AbstractThis paper examines the impact of perceived innovativeness on the success of equity crowdfunding campaigns. Building on the investor perspective, we hypothesize a positive impact of perceived innovativeness on the campaign outcome. Our database covers 191 campaigns launched in France on different platforms, drawing on over 2,000 individual assessments of the perceived innovativeness of the start‐ups involved, carried out by 176 participants with diverse backgrounds. We find support for our hypothesis from the investor perspective in that highly innovative projects attract more crowd investors and, in turn, raise more capital. We contribute to the understanding of how the crowd makes investment choices.
Up, down, and away: placing privilege in Bucharest, Romania
Authors: O'Neill Bruce 
Published: December 2021

AbstractAnthropologists have become increasingly sophisticated in the analysis of class by detailing the urban margins, by ‘studying up’ to examine elite wealth, and by charting the rise of the global middle classes. The anthropological commitment to depth, however, tends to keep these three strata separate in ways that mirror analytically the kind of segregation observed on the ground. Tight analytical framings risk obscuring the co‐ordinates of privilege, especially in cities such as Bucharest, Romania, which are being rapidly transformed by foreign direct investment (FDI). This article, by contrast, moves across Bucharest's diverging strata to explore the complex interconnections between the pursuit of FDI, urban planning, and increased class separation. Ethnographically, the article examines the production of three kinds of emergent spaces – homeless shelters for the very poor; high‐rise towers for the truly elite; and metro stations designed for the middle classes – to trace the interrelated politics of belonging and exclusion in a rapidly transforming city. The article suggests that these efforts, successful as they may be at ordering competing claims to the city, produce a landscape that cements unequal class relations into the built environment. Taken from Bucharest, this analysis offers wider insight into the future of contemporary urbanism in the European Union but also in cities the world over that are being similarly remade to attract global capital.