bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual Disorder in Men and Its Therapy with the Use of Phosphodiesterase Inhibitor Type 5 Eroton (Sildenafil Citrate)
Authors: Gurzhenko Yurii 
Published: July 2021

The study investigated the clinical efficacy of the drug Eroton in the treatment of sexual disorders, shows the effect of the study drug on the state of the sexual functions of patients; the degree of patient satisfaction with treatment was assessed; studied the tolerability and possible side effects of the study drug in men in a group of 110 patients. After a course of one month of treatment, all the integrative indicators of ICEF significantly increased in patients. The indicator «erectile function» increased from 12.54±0.87 to 25.12±1.32 (p<0,01), «satisfaction with intercourse» from 7.97±0.40 to 14.63±0.84 (p<0,01), «orgasm» – from 4.52±0.18 to 9.02±0.32 (p<0.01), «general satisfaction» – from 4.03±0.22 up to 8.27±0.46 (p<0,01).
The clinical efficacy of the treatment of erectile dysfunction showed «excellent» and «good» results in 92.7 % of patients. When studying the effect of the drug Eroton on the hormonal background in patients, there is a certain tendency to an increase in the content of testosterone in the serum of peripheral blood. This, from our point of view, is due to an improvement in the quality of sex life and an increase in its frequency. The indicator of «sex drive» of the ICEF questionnaire increased by 63.2 %. Improvement of the data on the ejaculatory component of sexual intercourse, which was assessed by the indicator of premature ejaculation in 61 men with this pathology, the clinical effectiveness of the course of treatment was 88.5 %. The time of the refractory period of sexual intercourse in patients decreased, which made it possible to carry out repeated sexual intercourse during the day in 34.5 % at the age of 22 to 34 years, and in 11.8 % of patients aged 22–29 years, 3 sexual intercourses were performed during the day. The frequency of sexual activity in patients with ED increased 2.1–2.4 times, and the quality of life index improved 3.8 times.
Patients well tolerated treatment with Eroton. The drug Eroton can be considered as a first-line drug in the treatment of erectile dysfunction.
Modern Methods of Treating Erectile Dysfunction in Young Men
Authors: Knigavko Oleksandr , Dorina Viktoriia 
Published: July 2021

Traditionally, the incidence of erectile dysfunction (ED) increases with the age of a man, evolutionarily protecting him from passing on old, defective genes to his offspring by limiting his participation in sexual activity. Nevertheless, in the modern world, only 1 % of sexual contacts are carried out for the purpose of reproduction, the rest – with a recreational and social purpose. In addition, there has been an increasing number of cases of ED in young men lately. The problem of treating ED in young patients (up to 45 years old) requires an etiological approach.
The objective: to determine the effectiveness of etiological non-surgical (treatment of prostatitis, psychotherapy) or minimally invasive (Marmara operation, veno-occlusive surgery, PRP-therapy) treatment of young men with ED.
Materials and methods. On the basis of the Kharkiv Regional Medical Clinical Center for Urology and Nephrology named after V.I. Shapoval and on the basis of the P. Mogila Black Sea National University (Nikolaev) during 2014–2020. a comprehensive examination and treatment of 563 patients was carried out, which were divided into three supergroups (A, B and C) according to the prevailing factor: 156 patients with venoocclusive erectile dysfunction – supergroup A, 353 patients with chronic prostatitis – supergroup B and 54 patients with predominant psychoneurological disorders and the absence of organic pathology - supergroup C.
Results. The effectiveness of surgical treatment in supergroup A according to subjective data after 2 months was almost equal in groups and subgroups, but after 18 months it was significantly higher in subgroups 1b and 2b (65.4 % and 83.7 %) according to ICEF results, and according to objective data after 18 months – 73.4 % and 91.4 %, respectively. After 1 and 7 months, the effectiveness of treatment in supergroup B was determined by the indices of satisfaction with sexual intercourse on the IIEF scale, the number of patients satisfied with the results of treatment, the absence of prostatic complaints and the eradication of infectious agents. Convincing results were obtained when assessing the quality of life of patients in supergroup C.
Conclusion. Chronic prostatitis is the most common cause of erectile dysfunction ED in young men. Three-week antibacterial etiological treatment demonstrates the highest rates of infection eradication and ICEF recovery in patients with prostatitis. Operation Marmara reduces venous hyperemia of the prostate, lowers the IPSS score, and improves erectile function in patients with comorbid pathology. The use of an etiological approach allows to improve the sexual function of young patients, returning them to a normal sexual life, creating an alternative to falloprosthetics.
Radium-223 in the Modern Treatment of Metastatic Castration-resistant Prostate Cancer
Authors: Golovko Serhii 
Published: July 2021

The objective: is to determine the current role of radium-223 in the emergence of new options in the treatment of patients with metastatic castration-resistant prostate cancer.
Materials and methods. Studies of ERA-223 and ALSYMPCA have identified the role of radium-223 in the treatment of prostate cancer and its impact on human health.
Results. In one such study, ERA-223, it was shown that the combination of abiraterone with radium-223 did not increase survival without symptomatic skeletal events compared with abiraterone plus placebo. In addition, a higher incidence of bone fractures was observed with the combination of abiraterone and radium-223, especially in patients not receiving osteomodulators (denosumab or zoledronic acid). These results have led to some changes in the indications for the use of radium-223 in Europe and more careful attention to the state of bone structure in patients with prostate cancer.
An overview of expert recommendations for the prevention and treatment of bone events, as well as the consequences of prolonged targeted therapy in patients with metastatic prostate cancer, which may improve the results of general and cancer-specific survival. Radium-223 has been shown to be an important option for patients with castration-resistant prostate cancer with bone metastases, and monitoring and maintaining bone health is an important factor in prostate cancer patients. It is established that the treatment of this category of patients should begin with androge n deprivation therapy.
Conclusions. A review of the recommendations of urologists, oncologists and radiation oncologists in Europe, who specialize in the treatment of patients with advanced prostate cancer, to maintain bone health, treatment consequences and the role of radium-223 in the treatment of prostate cancer. Based on the analysis of the use of radium-223 in the current treatment of CRPD, preventive measures to maintain bone health are recommended, as well as side effects based on clinical experience.
Features of hemostasis before and long-term periods in patients after ovarian apoplexy
Authors: Ishak O.M. 
Published: July 2021

The objective: to reveal the features of the parameters of the blood coagulation system in women in dynamics – from the acute period of ovarian apoplexy to the long-term postoperative period.Materials and methods. The study involved 82 women (main group, n=82), operated on for ovarian apoplexy, and 30 patients in the control group (n=30), who had no history of this pathology. All patients underwent a comprehensive examination using clinical, instrumental and laboratory research methods. The groups were homogeneous in age (average age was 26,1±2,3 years) and statistically comparable.Results. During the study, it was found that in the acute period of ovarian apoplexy, pathological changes were found in the plasma, vascular-platelet components and the fibrinolytic system of hemostasis, as evidenced by the lengthening of the thrombin time to 22,3±1,32 seconds, an increase in the concentration of fibrinogen to 6,73±0,64 g/l, SFMC up to 0,7±0,03 g/l and platelet hyperaggregation, stimulated by ADF, ristocetin and collagen, and reaching 80%. The extremely high content of D-dimer in the abdominal cavity in patients with ovarian apoplexy indicated increased thrombus formation in the damaged ovary, followed by activation of the fibrinolytic system and lysis of fibrin clots. Genetic thrombogenicity was found in general in 80,4% of patients, including those with a predominant lesion of the folate cycle enzymes - in every second patient.Positive dynamics with a tendency to normocoagulation was observed in the distant postoperative period. In the reference range were SFMC indices in 86,6% of cases, fibrinogen and thrombin time in 89,1% of cases, ristocetin-stimulated aggregatogram in 95,1% of cases (p<0,05).Conclusions. In women who underwent ovarian apoplexy, in the acute period of the disease, pathological changes in the vascular-platelet link of the hemostasis system were observed. The diagnosed thrombophilic disorders could lead to a deterioration in the rheological properties of blood, a violation of the processes of oxygenation and tissue trophism. The dynamic study of the hemostasis system in the acute and late postoperative periods of patients with ovarian apoplexy, as well as the data obtained on the prevalence of genetic thrombogenicity in the examined patients, should be taken into account when managing women from this risk group.
Importância da Equipe Multiprofissional para a recuperação da criança com fenda labiopalatina
Authors: Andrade Carla Alves , Rodrigues Mylena Costa , Santos Walquiria Lene 
Published: July 2021

Introdução: Relato de caso de uma criança que nasceu com fenda labiopalatal. Uma alteração que atinge cerca de 1 a cada 800 crianças, podendo ocorrer por diversos fatores incluindo fatores genéticos e o uso de álcool e drogas feito pela mãe durante o período gestacional. Objetivo: Descrever a trajetória de uma criança que nasceu no Distrito Federal com a má formação no lábio e palato, tendo grande parte do seu tratamento realizado no Hospital Regional da Asa Norte. Este estudo mostra as dificuldades encontradas pela criança portadora da malformação, os cuidados necessários no pré e pós-operatório, na realização das cirurgias e os problemas futuros relatados pelos pais da criança. Método: O estudo trata-se de um relato de caso qualitativo e para obter as informações foram utilizados exames, fotos, entrevistas feitas com o pai e a mãe da criança e uma revisão de literatura como forma de complemento. Resultado: O caso relatado mostra que quanto antes a criança for submetida aos cuidados necessários, melhor será o resultado final dos tratamentos, evitando assim, que essa condição possa causar transtornos maiores para a vida da paciente conforme for crescendo. Conclusão: O trabalho realizado pela equipe multiprofissional em conjunto com a família da criança, são fundamentais para a superação de dificuldades.
Percepção de homens sobre a influência da alimentação no câncer de próstata
Authors: Oliveira Pâmela Scarlatt Durães , Fernandes Queiroz Patricia Sousa , Lima Clara Cynthia Melo , Rocha Rodrigo Marques Batista , Barbosa Henrique Andrade , Vieira Isabella Batista 
Published: July 2021

Objetivo: conhecer a percepção do homem sobre a influência da alimentação no câncer de próstata a fim de favorecer a elaboração de ações de prevenção e controle desta doença.
Metodologia: ensaio comunitário realizado com 60 homens cadastrados em uma Estratégia Saúde da Família da cidade de Montes Claros (MG) com faixa etária superior a 40 anos. A coleta de dados ocorreu em três reuniões na forma de grupo focal. A análise de conteúdo temática e os dados foram organizados no software – Atlas Ti.
Resultados: conforme os objetivos desse estudo emergiram uma categoria e três subcategorias temáticas em que são apresentados o significado da interferência da alimentação para o câncer de próstata, em que os homens demonstram pouco conhecimento acerca de alimentos que protegem ou favorecem o surgimento do câncer de próstata; a influência das interações sociais na alimentação, subcategoria que demonstra a relevância do contexto social para adoção de hábitos alimentares saudáveis por parte dos homens e a importância do profissional de saúde na promoção de hábitos alimentares saudáveis.
Conclusão: os homens entrevistados apresentam conhecimento ainda incipiente sobre a influência da alimentação na prevenção ou favorecimento do surgimento do câncer de próstata. Sugere-se, portanto, que os profissionais nos diferentes espaços de cuidado, orientem a população masculina sobre hábitos alimentares saudáveis, focando nos alimentos que previnem o aparecimento do câncer.
Influence of External Parameters on Arc Fluctuations in a F4 DC Plasma Torch Used for Thermal Spraying
Authors: Dorier J.-L , Hollenstein C. , Salito A. , Loch M. , Barbezat G. 
Published: July 2021

Abstract
Plasma spray coating has achieved outstanding technological and commercial progress. However the underlying fundamentals still require a better understanding to overcome some limitations coming from, in particular, the instabilities of the arc and the strong erosion of the electrodes. In this paper we present experimental investigations of the fluctuating behavior of a Sulzer Metco F4 gun operated at atmosphere. The temporal evolution of the torch voltage and current, and of the plasma jet emission have been measured, hi addition, an optical fiber inserted inside the gun allows to measure fluctuations of the arc emission directly. Depending on the external parameters, different modes of operation have been identified. In the "restrike" mode which prevails for spraying-relevant operation conditions, detailed analysis of the voltage signals and corresponding arc and jet light emission reveals different categories of voltage drops corresponding to arc interruptions or reconnections. Spectral analysis of the different fluctuation signals shows clearly-defined peaks in the frequency range 3-30 kHz which are attributed to the arc motion and restrike inside the torch. The dependence of these peaks on operation conditions in terms of gas flows and composition, and gas injection geometry is presented. In addition a study of the effect of electrode aging on the torch fluctuations is reported.
A New Sensor for On-Line Monitoring the Temperature and Velocity of Thermal Spray Particles
Authors: Bourque G. , Lamontagne M. , Moreau C. 
Published: July 2021

Abstract
In this paper, we describe a new sensor for monitoring inflight particles in thermal spray processes. The sensor can measure simultaneously and in real-time, the mean velocity and mean temperature of the particle jet for a very broad range of powder feed rates. The thermal radiation emitted by the hot particles is collected by a lens and focused on two optical fibers. Knowing the distance between the optical fibers and the magnification of the optics, the mean particle velocity is computed by measuring the time delay between the signals collected in the two fibers by cross-correlation. The signals are band-pass filtered to prevent spurious reflection, equipment movement and noise from disturbing the measurement. Using the same signals filtered at two specific wavelengths, the mean temperature of the particle jet is obtained by the two-color pyrometry technique. In this technique, the temperature is computed from the ratio of the light intensity detected at two different wavelengths.
Effect of Powder Properties such as Particle Size, Density and Melt Flow Rate on the Properties of Flame Sprayed PE Coating
Authors: Rajamäki E. , Leino M. , Vuoristo P. , Järvelä P. , Mäntylä T. 
Published: July 2021

Abstract
Three different types of polyethylene powders were flame sprayed onto pre-heated steel substrate previously coated by electrostatic spray system with a thin epoxy primer layer. Properties of the polyethylene (PE) powders, including powder density, particle size and melt flow rate (MFR) were measured in order to study their influence on the mechanical properties of the coating. The spray experiments started with optimization of spraying parameters. The main variables were pre-heating temperature of the substrate, temperature increase during spraying (influenced by the spraying distance), and thickness of the PE coatings. The laboratory tests performed for the coatings were coating characterization by microscopy and mechanical testing. Porosity and thickness of the coatings were determined by optical and stereo microscopy studies from polished cross-sectional samples. Hardness, impact strength, peel strength, and adhesive strength of the coatings were also investigated. Also some hot water sinking and heat cycling tests were performed. As a result from the present studies it can be concluded that powder properties have great influence on the mechanical properties of the final coating.
Residual Stress Analysis of Solid Lubricant Containing Coatings on Light Metal Alloys for Aluminum Engine Components
Authors: Buchmann M. , Gadow R. 
Published: July 2021

Abstract
Mechanical coating properties like hardness, bond strength and tribological features as well as the layer composite lifetime under thermal and mechanical operation stress conditions are mainly influenced by the residual stress situation in the composite. The final residual stress state in thermally spray coated composites is superimposed by different stress mechanisms occurring during the manufacturing process. By means of the micro milling method, residual stresses are measured in a quasi-nondestructive way over the drilling depth. This paper describes the measurement features as well as experimental and numerical results. Measurements are performed on coated plane composite specimens as well as on inside coated bushing guides of aluminum crankcases for different coating materials. The correlation between residual stresses and coating properties is investigated.
Solid Lubricant Containing Coatings for Cylinder Liners in Pressure Casted Aluminum Crankcases
Authors: Buchmann M. , Gadow R. , Killinger A. 
Published: July 2021

Abstract
This paper evaluates a wide range of thermal spray coatings for potential use lining cylinder bores in aluminum engines. Coatings were applied by atmospheric plasma spraying (APS) and high-velocity oxyfuel (HVOF) techniques. More than a dozen coating materials were screened, including ceramics, cermets, and metals. The paper describes the equipment and procedures used in the investigation and assesses the resulting coatings based on their microstructure, hardness, friction coefficient, wear resistance, bonding strength, and residual stress.
Microstructure Engineering of Molybdenum Disilicide Based Materials Using Plasm a Spraying
Authors: Vaidya R.U. , Castro R.G. , Mendoza D. , Ayala A. , Petrovic J.J. , Hollis K.J. , Gallegos D.E. 
Published: July 2021

Abstract
Plasma spraying was used to produce continuously graded and layered structures of molybdenum disilicide and alumina. These microstructures were achieved by manipulating the powder hoppers and plasma torch translation via in-house created computer software. The resultant microstructures sprayed uniformly and were crack free. The mechanical and thermal performance of these sprayed materials will be evaluated through C-ring tests and thermal cycling experiments respectively. The purpose of this study is two fold; firstly to demonstrate the ability of produce such composite ceramic microstructures using a conventional plasma spraying process, and secondly to quantify the improvements in thermo-mechanical performance provided by these composite microstructures over conventional monolithic microstructures.
The Effect of Oxidation on Microstructure and Properties of TiC-Based Cermet Coatings
Authors: Gärtner F. , Kreye H. , Borck V. , Krömmer W. 
Published: July 2021

Abstract
In cutting tool technologies WC-Co based materials are increasingly replaced by composites containing TiC as hard phase and Ni or Co based metallic binders to improve life time and the performance at higher temperatures. These new light-weight materials are also promising for wear resistant coatings. However, while the production of WC-Co coatings by thermal spray techniques, especially high velocity oxy-fuel flame (HVOF) spraying, is well-established, thermal spraying of TiC-based powders did not lead to satisfactory results so far. This could be attributed to the oxidation during the spray process and the insufficient bond between hard phases and the metallic binder. Strategies to improve the properties of TiC-based coatings aim for microstructural modifications, especially by alloying additives into the thermal spray powder. By HVOF and vacuum plasma spraying (VPS), modified TiC-based coatings are produced, which globally show similar microstructures but significantly differ in their oxide contents. Investigations of mechano-technological properties and wear mechanisms demonstrate that alloying Mo into the hard phases or the metallic binder of thermal spray powders can improve the adhesion between hard phases and metallic binder of the coatings. In addition, properties of the metallic matrix can be tuned up for specific applications by solution hardening. In case of HVOF-coatings these effects are partially compensated by high oxygen contents. The overall better performance of coatings produced by VPS demonstrates that the high potential to improve properties of TiC-based composites by alloying additives can only be attained by minimizing the oxidation during the spray process.
Structure-Dielectric Behavior Relationships in HVOF Sprayed BaTiO3
Authors: Dent A.H. , Patel A.S. , Gutleber J. , Sampath S. , Herman H. , Tormey E. 
Published: July 2021

Abstract
BaTiO3 has been successfully sprayed by HVOF to produce dense 25-150 µm thick deposits for use as dielectric and capacitive layers within prototype multilayer conformal electronics. Parameter optimization has been shown to play a critical role in the effective spraying of these materials as thin structurally homogeneous deposits. The affect of standoff distance and combustion chamber size on the phase structure of the coatings have been studied and related to the dielectric properties of the layer. The proportion of crystalline to amorphous phase was found to be critically dependent upon the degree of melting of the particles in the flame and the rate of cooling of the deposits. The crystalline/amorphous ratio is directly related to the dielectric properties of the layer with greater crystallinity giving higher values of dielectric constant. Microcracks and splat/splat interfaces are also believed to adversely affect the dielectric properties. The maximum dielectric constant (K) values achieved using the HVOF method for deposition have been in the range 70-115.