bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genesungsbegleitung: Inanspruchnahme und Nutzenbewertung aus Betroffenenperspektive – Ergebnisse einer Beobachtungsstudie
Authors: Gühne Uta , Richter Daniel , Breilmann Johanna , Täumer Esther , Falkai Peter , Kilian Reinhold , Allgöwer Andreas , Ajayi Klemens , Baumgärtner Jessica , Brieger Peter , Frasch Karel , Heres Stephan , Jäger Markus , Küthmann Andreas , Putzhammer Albert , Schneeweiß Bertram , Schwarz Michael , Becker Thomas , Kösters Markus , Riedel-Heller Steffi G. 
Published: December 2021

ZusammenfassungZiel der Studie Genesungsbegleitung spielt in der Behandlung schwer psychisch erkrankter Menschen eine zunehmende Rolle. Zur Wirksamkeit liegen internationale Befunde vor. Über Wissen, Nutzung und Nutzenbewertung ist in Deutschland bisher wenig bekannt. Die vorliegende Arbeit geht dieser Frage nach und stellt Ergebnisse aus einer Beobachtungsstudie mit 10 teilnehmenden Zentren in Süddeutschland vor.Methodik Im Rahmen der beobachtenden Querschnittsstudie mit schwer psychisch erkrankten Menschen (IMPPETUS, N=359) wurden zwischen März und September 2019 soziodemografische sowie krankheits- und behandlungsassoziierte Daten erhoben. Mittels binär logistischer Regression wurde ein möglicher Zusammenhang mit der Nutzung von Genesungsbegleitung analysiert.Ergebnisse 38% (N=138) der Befragten gaben an, von der Möglichkeit der Genesungsbegleitung zu wissen; 15% (N=55) bejahten deren Nutzung. Eine Nutzung schwankte zwischen 6,5 und 37,5% über die Standorte und war mit dem Haushaltseinkommen verbunden. Deutlich seltener wurde Genesungsbegleitung von Personen mit einem hohen gegenüber Personen mit einem geringen Haushaltseinkommen genutzt (OR=0,20 [95% CI: 0,06–0,68], p=0,01). Von den Nutzenden (N=55) gaben 78% an, diese als hilfreich bzw. äußerst hilfreich wahrgenommen zu haben.Diskussion Genesungsbegleitung erweist sich nicht nur unter Studienbedingungen hinsichtlich verschiedener Outcomes als wirksam, sondern wird auch unter Routinebedingungen in einer umschriebenen Versorgungsregion von der Mehrheit der Nutzenden als wirksam eingeschätzt. Allerdings müssen Wissen und Nutzung hinsichtlich einer Genesungsbegleitung unter (teil)stationär behandelten Personen als gering verteilt bewertet werden.Schlussfolgerung Um Genesungsbegleitung stärker in die Praxis zu implementieren, muss wirksamer als bisher über dieses Unterstützungsangebot informiert und ein (über-)regionaler Austausch über erfolgreiche Implementierungserfahrungen angestrengt werden.
The participatory turn in health and medicine: The rise of the civic and the need to ‘give back’ in data-intensive medical research
Authors: Siffels Lotje E. , Sharon Tamar , Hoffman Andrew S. 
Published: December 2021

AbstractWhat has been called the “participatory turn” in health and medicine refers to a general shift from paternalistic and hierarchical, to more collaborative and egalitarian relationships between medical experts and patients/research participants; a shift from what the pragmatic sociologists Boltanski and Thévenot (2006) call a “domestic” to a “civic” order of worth. Critical scholarship on the participatory turn tends to emphasize discrepancies between ideals of equality and empowerment, and practices of increased individual responsibility and disempowerment. In this paper, we depart from this critical literature by suspending evaluation about authentic and inauthentic ideals and practices. Instead, we explore the issues and challenges that arise in the process of ensuring that ideal and practice align in what we call a civic-participatory style of doing medical research. Drawing on interviews and observations carried out with medical researchers, coordinators and assessors in a longitudinal cohort study called the Personalized Parkinson’s Project (PPP), we show that for study staff it is often unclear how they can meet the demands of reciprocity towards research participants that are presupposed by civic-participatory ideals. In particular, in the context of a study whose aim is the creation of a comprehensive dataset comprised of clinical, environmental and lifestyle data that study participants generously “give” over a period of 2 years, we observed a persistent concern on the part of study staff regarding what and how to “give back”. As we show, study staff negotiate and resolve this tension through recourse to creative workarounds and innovative ways of giving back, including frequent project and scientific updates, newsletters, the designation of personal assessors and pampering Event Days. The paper makes a contribution to the critical literature on the participatory turn by showing the utility of the orders of worth framework in probing the challenges and workarounds that emerge in settings where an incumbent style of organizing medical research (here, the 'civic') comes to challenge practices hitherto organized according to a wholly different logic (in this case, the 'domestic')—without making assumptions about the (in)authenticity of such ideals and practices. Moreover, we contend that this framework offers new tools for evaluating participatory research projects in the form of “good” or “successful” civic–domestic compromises.
Design of a tunable electromagnetic vibration absorber for transient vibration suppression under impulse
Authors: Wang Xi , Xu Zhenyuan , Wang Dida 
Published: December 2021

Vibration absorbers usually aim to control the steady-state vibration of harmonic excitation based on the traditional fixed point theory, but few efforts focus on suppressing the transient vibration caused by impulse excitation. In this paper, the excitation is regarded as impulse in modeling, and it can be used for impulse excitation. Thus, the transient vibration absorber is designed to control the transient vibration, and the stiffness of the absorber is a key factor to control the response of the primary system. This paper presents a tunable electromagnetic transient vibration absorber to avoid direct mechanical contact for the absorber. The analytical results of the transient response indicate that the vibration can be attenuated by adjusting the stiffness of the absorber. In order to establish the model of the electromagnetic stiffness, the absorber is divided into three equivalent virtual springs. The circular current loop is equivalent to the rectangular current loop to show the spatial distribution of the magnetic flux density in the air gap. The experimental tests demonstrate that the transient vibration of the primary system can be attenuated by 13% when the current of the coil is 6 A.
Tunable homogeneous kG magnetic field production using permanent magnets
Authors: Pizzey Danielle 
Published: December 2021

We present a permanent ring magnet arrangement that can achieve a tunable axial magnetic field from 1.80(5) to 2.67(9) kG. The apparatus has been designed to accommodate a cylindrical atomic vapor cell of length 25 mm and diameter 25 mm to lie within the bore of the ring magnets, providing an alternative route for imaging through atomic vapors in large magnetic fields. The measured axial magnetic field has an rms variation of less than 4% over the length of vapor cell, while the calculated field inhomogeneity is less than 5% radially and 12% longitudinally across a cylindrical volume with diameter 20 mm and length 25 mm. The instrument consists of layered concentric off-the-shelf N42 neodymium–iron–boron axially magnetized ring magnets. The magnets are organized into four cylindrical brass holders, whose relative separation can be manipulated to achieve the desired magnetic field strength. We present magnetic field computations and Marquardt–Levenberg fits to experimental data and demonstrate excellent agreement between theory and experiment.
Dynamics of exciton–polariton emission in CuI
Authors: Krüger Evgeny , Bar Michael S. , Blaurock Steffen , Trefflich Lukas , Hildebrandt Ron , Müller Andreas , Herrfurth Oliver , Benndorf Gabriele , von Wenckstern Holger , Krautscheid Harald , Grundmann Marius , Sturm Chris 
Published: December 2021

We report on temperature-dependent (10 K – 250 K) spectral and dynamical properties of free exciton–polariton and bound exciton emission in copper iodide (CuI) bulk single crystals analyzed by means of time-resolved photoluminescence spectroscopy. The characteristic line shape of the polariton emission at low temperatures is interpreted in terms of the “k-linear term effect” on the degenerate Z1,2 excitons in CuI. For free exciton–polaritons, an increase in the decay time with increasing temperature up to 360 ps at 160 K is observed. For bound exciton emission, decay times between 180 ps and 380 ps are observed at low temperatures, revealing the expected EB3/2 dependence of radiative lifetime on the localization energy. Based on the observed rise times of bound excitons at low temperatures, a defect density of shallow acceptors of 1 × 1017 cm−3 was estimated, in agreement with measured room temperature free hole density.
An advanced optical–electrochemical nanopore measurement system for single-molecule analysis
Authors: Liu Shao-Chuang , Xie Bao-Kang , Zhong Cheng-Bing , Wang Jia , Ying Yi-Lun , Long Yi-Tao 
Published: December 2021

Nanopore measurement has advanced in single-molecule analysis by providing a transient time and confined space window that only allows one interested molecule to exist. By optimization and integration of the electrical and optical analysis strategies in this transient window, the acquisition of comprehensive information could be achieved to resolve the intrinsic properties and heterogeneity of a single molecule. In this work, we present a roadmap to build a unified optical and electrochemical synchronous measurement platform for the research of a single molecule. We design a low-cost ultralow-current amplifier with low noise and high-bandwidth to measure the ionic current events as a single molecule translocates through a nanopore and combine a multi-functional optical system to implement the acquisition of the fluorescence, scattering spectrum, and photocurrent intensity of single molecule events in a nanopore confined space. Our system is a unified and unique platform for the protein nanopore, the solid-state nanopore, and the glass capillary nanopore, which has advantages in the comprehensive research of nanopore single-molecule techniques.
Conduction channel configuration controlled digital and analog response in TiO2-based inorganic memristive artificial synapses
Authors: Simanjuntak Firman Mangasa , Hsu Chun-Ling , Abbey Thomas , Chang Lung-Yu , Rajasekaran Sailesh , Prodromakis Themis , Tseng Tseung-Yuen 
Published: December 2021

The operating current regime is found to play a key role in determining the synaptic characteristic of memristor devices. A conduction channel that is formed using high current compliance prior to the synaptic operation results in digital behavior; the high current stimulus forms a complete conductive filament connecting the cathode and anode, and the high electric field promotes abrupt redox reactions during potentiation and depression pulsing schemes. Conversely, the conduction can be reconfigured to produce a filamentary-homogeneous hybrid channel by utilizing the low current stimulus, and this configuration enables the occurrence of analog behavior. The capabilities of memristors showing programmable digital-to-analog or analog-to-digital transformation open a wide range of applications in electronics. We propose a conduction mechanism to explain this phenomenon.
Chemomechanical equilibrium at the interface between a simple elastic solid and its liquid phase
Authors: Sprik Michiel 
Published: December 2021

Applying diffusion coupled deformation theory, we investigate how the elastic properties of a solid body are modified when forced to keep its chemical potential aligned with that of its melt. The theory is implemented at the classical level of continuum mechanics, treating materials as simple continua defined by uniform constitutive relations. A phase boundary is a sharp dividing surface separating two continua in mechanical and chemical equilibrium. We closely follow the continuum theory of the swelling of elastomers (gels) but now applied to a simple two phase one-component system. The liquid is modeled by a local free energy density defining a chemical potential and hydrostatic pressure as usual. The model is extended to a solid by adding a non-linear shear elastic energy term with an effective modulus depending on density. Imposing chemomechanical equilibrium with the liquid reservoir reduces the bulk modulus of the solid to zero. The shear modulus remains finite. The stability of the hyper-compressible solid is investigated in a thought experiment. A mechanical load is applied to a rectangular bar under the constraint of fixed lateral dimensions. The linear elastic modulus for axial loading is evaluated and found to be larger than zero, implying that the bar, despite the zero bulk modulus, can support a weight placed on its upper surface. The weight is stabilized by the induced shear stress. The density dependence of the shear modulus is found to be a second order effect reducing the density of the stressed solid (chemostriction).
Data-driven modeling of S → S1 excitation energy in the BODIPY chemical space: High-throughput computation, quantum machine learning, and inverse design
Authors: Gupta Amit , Chakraborty Sabyasachi , Ghosh Debashree , Ramakrishnan Raghunathan 
Published: December 2021

Derivatives of BODIPY are popular fluorophores due to their synthetic feasibility, structural rigidity, high quantum yield, and tunable spectroscopic properties. While the characteristic absorption maximum of BODIPY is at 2.5 eV, combinations of functional groups and substitution sites can shift the peak position by ±1 eV. Time-dependent long-range corrected hybrid density functional methods can model the lowest excitation energies offering a semi-quantitative precision of ±0.3 eV. Alas, the chemical space of BODIPYs stemming from combinatorial introduction of—even a few dozen—substituents is too large for brute-force high-throughput modeling. To navigate this vast space, we select 77 412 molecules and train a kernel-based quantum machine learning model providing &lt;2% hold-out error. Further reuse of the results presented here to navigate the entire BODIPY universe comprising over 253 giga (253 × 109) molecules is demonstrated by inverse-designing candidates with desired target excitation energies.
Free recall scaling laws and short-term memory effects in a latching attractor network
Authors: Boboeva Vezha , Pezzotta Alberto , Clopath Claudia 
Published: December 2021

Significance
The ability to store and retrieve information is a crucial function of memory in the brain. One well-established paradigm in which this is tested is free recall, in which a number of robust features and biases characterize the statistics of recall. Although these laws are consistently reproduced, the neuronal basis of how they emerge is not clear. In this manuscript, we propose a neural network model with a plausible learning rule that expresses these laws that may provide a mechanistic insight into memory function. In particular, our model reproduces power laws governing the recall capacity, as well as the biases that human subjects use to guide recall, such as the use of temporal and semantic cues.
Pedestrian dynamics at the running of the bulls evidence an inaccessible region in the fundamental diagram
Authors: Parisi Daniel R. , Sartorio Alan G. , Colonnello Joaquín R. , Garcimartín Angel , Pugnaloni Luis A. , Zuriguel Iker 
Published: December 2021

Significance
A topic of special interest in crowd dynamics that can lead to better infrastructure management is the study of people under high competitiveness. Persons fleeing from real danger is one instance of this scenario, but of course it is difficult to analyze it experimentally. This is why people running with bulls at the San Fermín Festival provides an exceptional annual event where real data of pedestrian dynamics under extreme conditions can be collected. This kind of data is scarce and therefore highly valuable.
Benchmarking the ideal sample thickness in cryo-EM
Authors: Martynowycz Michael W. , Clabbers Max T. B. , Unge Johan , Hattne Johan , Gonen Tamir 
Published: December 2021

Significance
A systematic investigation of the effects of sample thickness on electron scattering in electron cryo-microscopy (cryo-EM) was previously not feasible. Here, methods are employed to investigate the effects of increasing sample thickness. Near identical protein crystals are used as samples, and microcrystal electron diffraction data are used to assess the effects of thickness. These experiments were conducted using the three most-common accelerating voltages in cryo-EM, and data were compared using the calculated inelastic mean free path. Structures may be determined using crystals up to twice the inelastic mean free path. No coherent information remains at thicknesses over four times the mean free path. This study provides limits for biological specimen thickness with implications for all cryo-EM methods.
Distinct roles of hnRNPH1 low-complexity domains in splicing and transcription
Authors: Kim Ga Hye , Kwon Ilmin 
Published: December 2021

Significance
Phase separation of low-complexity (LC) domains appended to most RNA-binding proteins (RBPs) emerges as a principle underlying spatiotemporal protein recruitment. Yet, how LC domains regulate the function of RBPs in cells remains unclear. An alternative-splicing regulator, hnRNPH1, contains two LC domains (LC1 and LC2). Here, we show that phase separation of the LC1 can exert control over hnRNPH1 function in RNA-splicing possibly by facilitating interactions between hnRNPH1 and a variety of RBPs. In contrast, the LC2 lacking in vitro phase properties, is required for aberrant transcriptional activation in the context of fusion oncoproteins. These results have broad implications for understanding how phase separation contributes to distinct roles of LC domains in control of physiological as well as oncogenic functions.
The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions
Authors: Yu Guojun , Zhang Yongwei , Gupta Varun , Zhang Jinghang , MacCarthy Thomas , Duan Zhi , Scharff Matthew D. 
Published: December 2021

Significance
We have shown that the immunoglobulin heavy chain V region mutation in human B cells is regulated by HIRA, which is a chaperone for H3.3, and found that H3.3 plays a role in V region mutation in part through its H3.3K36me3 modification. The absence of HIRA is associated with a change in V region chromatin accessibility. HIRA depletion and expression of the H3.3G34V mutant also decreased the recruitment of several transcriptional elongation factors, including ZMYND11, which had not previously been shown to be involved in V region mutation. These and other findings extend our knowledge of the role of chromatin structure and of transcription in regulating V region hypermutation.
Single-molecule sequencing reveals a large population of long cell-free DNA molecules in maternal plasma
Authors: Yu Stephanie C. Y. , Jiang Peiyong , Peng Wenlei , Cheng Suk Hang , Cheung Y. T. Tommy , Tse O. Y. Olivia , Shang Huimin , Poon Liona C. , Leung Tak Y. , Chan K. C. Allen , Chiu Rossa W. K. , Lo Y. M. Dennis 
Published: December 2021

SignificanceWe revealed a large population of long cell-free DNA molecules (up to 23,635 bp in length) in maternal plasma and developed an approach which leveraged the abundance of CpG sites on long molecules to deduce the tissue of origin of individual plasma DNA molecules based on single-molecule methylation analysis. We illustrated how such an approach may be utilized to achieve noninvasive prenatal testing of monogenic diseases. We also revealed a reduction in amounts of such long cell-free DNA molecules and a different end motif profile in maternal plasma DNA from pregnancies with preeclampsia. Hence, long cell-free DNA molecules represent a valuable resource of biomarker development for pregnancy-associated disorders.
A short binding site in the KPC1 ubiquitin ligase mediates processing of NF-κB1 p105 to p50: A potential for a tumor-suppressive PROTAC
Authors: Goldhirsh Gilad , Kravtsova-Ivantsiv Yelena , Satish Gandhesiri , Ziv Tamar , Brik Ashraf , Ciechanover Aaron 
Published: December 2021

Significance
Accumulation of abnormal proteins underlies the mechanisms of numerous diseases such as malignancies and neurodegeneration. A recent development makes use of the UPS to remove such proteins. Small molecules (PROTACs) that are made of two heads—one that binds to a “universal” Ub ligase and the other that binds to the target substrate—bring the two together, which results in ubiquitination and subsequent proteasomal degradation of the target. We designed a PROTAC made of the pVHL ligase ligand and the short site of the KPC1 ligase that binds the p105 NF-ĸB precursor. The PROTAC mimics the enzymatic activity of the native KPC1 and can therefore serve as a prototype for the development of a tumor-suppressive drug.
A social theory of resilience: The governance of vulnerability in crisis-era neoliberalism
Authors: McKeown Anthony , Hai Bui Dang , Glenn John 
Published: December 2021

ABSTRACT
In this paper, we set out a critical realist-informed Marxist approach to resilience, the principal argument being that the discourse is best explicated through a theoretical lens which situates its rise in the context of a neoliberal order which is undergoing a global organic crisis. Our key contribution to the literature is to show not only that extant resilience discourses ontologise vulnerability and thereby strip political discourse of the language of social struggle, but also that they provide a crisis-recovery imaginary more congenial to the interests of capital and state than to the vulnerable populations they ostensibly aim to capacitate. We conclude by joining a chorus of other scholars committed to exposing resilience as an insidious technology of the self.
Magnification and evolution biases in large-scale structure surveys
Authors: Maartens Roy , Fonseca José , Camera Stefano , Jolicoeur Sheean , Viljoen Jan-Albert , Clarkson Chris 
Published: December 2021

Abstract
Measurements of galaxy clustering in upcoming surveys such as those planned for the Euclid and Roman satellites, and the SKA Observatory, will be sensitive to distortions from lensing magnification and Doppler effects, beyond the standard redshift-space distortions. The amplitude of these contributions depends sensitively on magnification bias and evolution bias in the galaxy number density. Magnification bias quantifies the change in the observed number of galaxies gained or lost by lensing magnification, while evolution bias quantifies the physical change in the galaxy number density relative to the conserved case. These biases are given by derivatives of the number density, and consequently are very sensitive to the form of the luminosity function. We give a careful derivation of the magnification and evolution biases, clarifying a number of results in the literature. We then examine the biases for a variety of surveys, encompassing
galaxy surveys and line intensity mapping at radio and optical/near-infrared wavelengths.