bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nutzerzufriedenheit in den sozialen Medien. Wie beurteilen Patienten ihren Krankenhausaufenthalt online?
Authors: Hopf Felix , Patzelt Christiane , Schindler Anja , Emmert Martin , Sander Uwe 
Published: April 2021

Zusammenfassung
Hintergrund Patienten nutzen zunehmend soziale Medien und Bewertungsportale, um sich über Krankenhäuser zu informieren, diese zu bewerten oder einen Erfahrungsbericht über den Krankenhausaufenthalt zu schreiben. Krankenhäuser haben die Möglichkeit, online abgegebene Patientenkritik für die interne Qualitätssicherung sowie das Online-Reputationsmarketing zu nutzen. Ziel der Studie: Ziel ist es, Zufriedenheitsbewertungen zu vorangegangen Krankenhausaufenthalten von Social Media Nutzern der Plattformen „Google“ sowie Nutzern des Bewertungsportals „Klinikbewertungen.de“ zu analysieren und plattformspezifisch zu vergleichen.
Methodik Es wurde eine Extraktion von Nutzerbewertungen (N=16 691) zu allen Krankenhäusern (N=180) im Bundesland Niedersachsen (Vollerhebung) auf den Plattformen Google und Klinikbewertungen.de für die Jahre 2013–2018 vorgenommen. Anschließend wurden deskriptive und induktive Analysen (Chi²-Test) der Nutzerbewertungen durchgeführt und ein plattformspezifischer Vergleich vorgenommen.
Ergebnisse Die meisten Nutzer sind mit ihrem Krankenhausaufenthalt zufrieden, wobei Nutzer der Plattform Google ihren Krankenhausaufenthalt schlechter bewerten (n=6 181; 57,6% zufrieden) als Nutzer der Plattform Klinikbewertungen (n=10 509; 65,4% zufrieden). Krankenhauseigenschaften (Bettenzahl, Fachabteilung), Eigenschaften des Nutzers (Verfasser, Versicherungsart) sind mit der Bewertung des Krankenhausaufenthaltes (Sternebewertung) signifikant assoziiert (Google: Bettenzahl p<0,001; Klinikbewertungen.de: Bettenzahl p<0,001, Verfasser p<0,001, Fachabteilung p<0,001, Versicherungsart p<0,001).
Schlussfolgerung Die Onlinebewertung eines Krankenhausaufenthaltes ist assoziiert mit der Bettenzahl und der Fachabteilung eines Krankenhauses sowie damit, ob der Verfasser Patient oder Angehöriger ist und ob eine private oder gesetzliche Krankenversicherung besteht. Diese Erkenntnisse können für die Interpretation von Onlinebewertung eines Krankenhausaufenthaltes verwendet werden und können die Nutzung von Online-Bewertungen für Krankenhäuser für die interne Qualitätssicherung oder zur Verbesserung der Online-Reputation unterstützen.
Consensus Recommendations for Intramuscular COVID-19 Vaccination in Patients with Hemophilia
Authors: Pfrepper Christian , Holstein Katharina , Königs Christoph , Heller Christine , Krause Manuela , Olivieri Martin , Bidlingmaier Christoph , Sigl-Kraetzig Michael , Wendisch Jörg , Halimeh Susan , Horneff Silvia , Richter Heinrich , Wieland Ivonne , Klamroth Robert , Oldenburg Johannes , Tiede Andreas ,   On Behalf of the Hemophilia Board of the German, Austrian, Swiss Society on Thrombosis Hemostasis Research (GTH)
Published: April 2021

AbstractBackground Currently available coronavirus disease 2019 (COVID-19) vaccines are approved for intramuscular injection and efficacy may not be ensured when given subcutaneously. For years, subcutaneous vaccination was recommended in patients with hemophilia to avoid intramuscular bleeds. Therefore, recommendations for the application of COVID-19 vaccines are needed.Methods The Delphi methodology was used to develop consensus recommendations. An initial list of recommendations was prepared by a steering committee and evaluated by 39 hemophilia experts. Consensus was defined as ≥75% agreement and strong consensus as ≥95% agreement, and agreement as a score ≥7 on a scale of 1 to 9. After four rounds, a final list of statements was compiled.Recommendations Consensus was achieved that COVID-19 vaccines licensed only for intramuscular injection should be administered intramuscularly in hemophilia patients. Prophylactic factor replacement, given on the day of vaccination with a maximum interval between prophylaxis and vaccination of 24 hours (factor VIII and conventional factor IX concentrates) or 48 hours (half-life extended factor IX), should be provided in patients with moderate or severe hemophilia. Strong consensus was achieved that patients with mild hemophilia and residual factor activity greater than 10% with mild bleeding phenotype or patients on emicizumab usually do not need factor replacement before vaccination. Swelling, erythema, and hyperthermia after vaccination are not always signs of bleeding but should prompt consultation of a hemophilia care center. In case of injection-site hematoma, patients should receive replacement therapy until symptoms disappear.Conclusions Consensus was achieved on recommendations for intramuscular COVID-19 vaccination after replacement therapy for hemophilia patients depending on disease severity.
Hygiene neu verstehen: Teil 1
Authors: Handke Denis 
Published: April 2021

SummaryBeim Hygienemanagement ist der PDCA-Zyklus eine verbreitete Vorgehensweise mit den Schritten Plan-Do-Check-Act (Planen, Durchführen, Evaluieren und Handeln). Auch zunächst simpel erscheinende Maßnahmen des Hygienemanagements, zum Beispiel die Händedesinfektion, erfordert die Einbindung zahlreicher Vorgaben, Richtlinien und individueller Fragestellungen. Das Hygienemanagement umfasst alle wichtigen Aspekte der Hygiene in der Praxis und sollte immer wieder geprüft, angepasst und in einem gebündelten Dokument festgehalten werden.
Gesunde Kinder durch Hydrotherapie nach Kneipp
Authors: Gündling Peter W. 
Published: April 2021

SummaryHydrotherapeutische Anwendungen nach Kneipp eigen sich gut für Kinder – teils eher prophylaktisch und teils eher therapeutisch beispielsweise bei akuten Atemwegsinfekten. Wendet man hydrotherapeutische Maßnahmen bei Kindern an, sind einige grundsätzliche Punkte zu beachten, zum Beispiel, dass bei Kaltanwendungen stets vor- und nachgewärmt werden muss. Zu den hydrotherapeutischen Anwendungen bei Kindern zählen vor allem Wassertreten, Güsse, Bäder, Inhalationen und Auflagen sowie Wickel.
vHTS and 3D-QSAR for the Identification of Novel Phyto-inhibitors of Farnesyltransferase: Validation of Ascorbic Acid inhibition of Farnesyltransferase in an Animal Model of Breast Cancer
Authors: Samuel Metibemu Damilohun 
Published: April 2021

AbstractFarnesyltransferase (FTase) is a zinc enzyme that has been the subject of attention in anti-cancer research over the past. In this study, phytochemicals from Curcuma longa L., Taraxacum officinale, and Spondias mombin plants were screened for their inhibitory potentials on the human farnesyltransferase. A three-dimensional quantitative structure-activity relationship (3D-QSAR) model for the inhibition of farnesyltransferase was generated and the inhibition of farnesyltransferase by the hit, ascorbic acid was validated in an animal model of breast cancer. The lead compound, ascorbic acid makes extensive hydrogen bond interactions with key residues, lys-353, tyr-300, gly-290, leu-290 within the active site of farnesyltransferase. It downregulated the expression of FNTA mRNA in an animal model of breast cancer. The 3D-QSAR generated herein is robust, thoroughly validated, and should be employed in the pipelining of novel farnesyltransferase inhibitors. Ascorbic acid demonstrates its anticancer potentials through the inhibition of farnesyltransferase.
Measuring Psychological Load in Sport
Authors: Mellalieu Stephen , Jones Christopher , Wagstaff Christopher , Kemp Simon , Cross Matthew J. 
Published: April 2021

AbstractMonitoring the physical load undertaken by athletes and examining the subsequent
relationship with performance and injury and illness risk is common practice in
high performance sport. Less attention has been paid to the psychological
factors contributing to the overall load experienced and the impact upon health
status and performance. This paper discusses considerations for the
conceptualization and measurement of psychological load in sport. First, we
outline the importance of ensuring conceptual clarity is adopted in the
measurement of psychological load. Next, we discuss the challenges to measuring
psychological load in a comparable manner to which physical load is currently
evaluated, including use of subjective assessment, adoption of specific and
global approaches, and development of measurement instrumentation, techniques,
and expertise. We then offer recommendations for practitioners when undertaking
assessment of psychological load in sport. We conclude with future research
directions to advance the study and measurement of the construct, including the
interaction between psychological and physical load, the appraisal of the load
faced, and personal and social resources available to successfully cope. We also
highlight the need to consider groups of athletes (e. g., transitioning
athlete, long-term injured) at greater risk from threats to mental and physical
health from increased psychological load.
Interoperator Reliability of Lung Ultrasound during the COVID-19 Pandemic
Authors: De Molo Chiara , Consolini Silvia , Salvatore Veronica , Grignaschi Alice , Lanotte Antonella , Masi Livia , Giostra Fabrizio , Serra Carla 
Published: April 2021

Abstract
Aim Lung ultrasound (LUS) is a reliable, radiation-free, and bedside imaging technique used to assess several pulmonary diseases. Although COVID-19 is diagnosed with a nasopharyngeal swab, detection of pulmonary involvement is crucial for safe patient discharge. Computed tomography (CT) is currently the gold standard. To treat paucisymptomatic patients, we have implemented a “fast track” pathway in our emergency department, using LUS as a valid alternative. Minimal data is available in the literature about interobserver reliability and the level of expertise needed to perform a reliable examination. Our aim was to assess these.
Materials and Methods This was a single-center prospective study. We enrolled 96 patients. 12 lung areas were explored in each patient with a semiquantitative assessment of pulmonary aeration loss in order to obtain the LUS score. Scans were performed by two different operators, an expert and a novice, who were blinded to their colleague’s results.
Results 96 patients were enrolled. The intraclass correlation coefficient (ICC) showed excellent agreement between the expert and the novice operator (ICC 0.975; 0.962–0.983); demographic features (age, sex, and chronic pulmonary disease) did not influence the reproducibility of the method. The ICC was 0.973 (0.950–0.986) in males, 0.976 (0.959–0.986) in females; 0.965 (0.940–0.980) in younger patients (≤ 46 yrs), and 0.973 (0.952–0.985) in older (> 46 yrs) patients. The ICC was 0.967 (0.882–0.991) in patients with pulmonary disease and 0.975 (0.962–0.984) in the other patients. The learning curve showed an increase in interobserver agreement.
Conclusion Our results confirm the feasibility and reproducibility of the method among operators with different levels of expertise, with a rapid learning curve.
Holmium-166 Radioembolization
Authors: Lam Marnix G. E. H. , Smits Maarten L. J. , Bruijnen Rutger C. G. , de Keizer Bart , Braat Arthur J. A. T. 
Published: April 2021

AbstractRadioembolization is usually performed with microspheres containing yttrium-90 (90Y). Holmium-166 (166Ho)-microspheres were developed as an alternative new product for radioembolization. The unique characteristics of 166Ho-microspheres allow for improved imaging possibilities. They can be visualized and quantified, already at low numbers and activities, to predict treatment distribution using 166Ho-microspheres at scout quantity during pre-treatment simulation. The option to reliably predict the distribution of microspheres provides physicians control over the treatment, allowing them to select and treat patients with a personalized treatment plan. Safety and efficacy were established in several clinical studies. 166Ho-microspheres radioembolization aims to optimize individualized treatment planning in order to improve treatment outcomes.
Age-Related Hearing Loss and the Development of Cognitive Impairment and Late-Life Depression: A Scoping Overview
Authors: Sharma Rahul K. , Chern Alexander , Golub Justin S. 
Published: April 2021

AbstractAge-related hearing loss (ARHL) has been connected to both cognitive decline and late-life depression. Several mechanisms have been offered to explain both individual links. Causal and common mechanisms have been theorized for the relationship between ARHL and impaired cognition, including dementia. The causal mechanisms include increased cognitive load, social isolation, and structural brain changes. Common mechanisms include neurovascular disease as well as other known or as-yet undiscovered neuropathologic processes. Behavioral mechanisms have been used to explain the potentially causal association of ARHL with depression. Behavioral mechanisms include social isolation, loneliness, as well as decreased mobility and impairments of activities of daily living, all of which can increase the risk of depression. The mechanisms underlying the associations between hearing loss and impaired cognition, as well as hearing loss and depression, are likely not mutually exclusive. ARHL may contribute to both impaired cognition and depression through overlapping mechanisms. Furthermore, ARHL may contribute to impaired cognition which may, in turn, contribute to depression. Because ARHL is highly prevalent and greatly undertreated, targeting this condition is an appealing and potentially influential strategy to reduce the risk of developing two potentially devastating diseases of later life. However, further studies are necessary to elucidate the mechanistic relationship between ARHL, depression, and impaired cognition.
Next Generation Sequencing of Y-STRs in Father-Son Pairs and Comparison with Traditional Capillary Electrophoresis
Authors: Bredemeyer Steffi , Roewer Lutz , Willuweit Sascha 
Published: April 2021

Abstract
To evaluate the promising advantages of massively parallel sequencing (MPS) in our casework, we analysed a total of 33 Y-chromosomal short tandem repeats (Y-STRs) with traditional capillary electrophoresis (CE) and 25 Y-STRs using the newer MPS technology. We studied the outcome of both technologies in 64 father-son pairs using stock and custom-designed kits. Current MPS technology confirmed the 13 mutational events observed with CE and improved our understanding of the complex nature of STR mutations. By detecting isometric sequence variants between unrelated males, we show that sequencing Y-STRs using MPS can boost discrimination power.
Morphological characteristics, chemical and amino acids composition of flours from velvet beans tempe (Mucuna pruriens), an indigeneous legumes from Yogyakarta
Authors: Fitriyah H , Anwar F , Palupi E 
Published: April 2021

Abstract
Velvet beans (Mucuna pruriens) an under-utilized legume which grown predominantly in tropical area, including in Indonesia. The morphological characteristics, chemical and amino acid composition of seeds, fermented velvet beans (Benguk tempeh), and Benguk tempeh flours from the legumes Mucuna pruriens was evaluated to determine their potential practical applications. The seeds of velvet beans contains 12.73±0.10, 4.34±0.33, 25.49±0.06, 3.66±0.03, 3.90±0.06, and 53.79±0.26 (% wb) of moisture, fat, crude protein, ash, crude fiber and carbohydrate, respectively. The mineral content of velvet seeds was 76.38±8.77, 6.64±0.67, and 3.08±0.12 mg 100 g1 of calcium, iron, and zinc, respectively. Fermentation process on velvet beans into tempeh brings nutritional changes including the breakdown of certain nutrition content and reduction of anti-nutritional compounds. The velvet beans tempeh contains 54.76±0.24, 2.40±0.16, 12.84±0.56, 1.02±0.13, 3.66±0.49, and 28.99±0.60 (% wb) moisture, fat, crude protein, ash, crude fiber and carbohydrate, respectively. The mineral content of velvet beans tempeh was 55.49±13.91, 6.56±0.39 and 2.60±0.33 mg 100 g1 of calcium, iron, and zinc, respectively. The flours were prepared by steam blanching, oven-drying (60°C) for 7h and milling. The flours contains 13.13±0.52, 6.78±0.72, 25.29±0.41, 0.76±0.04, 4.34±0.32, and 54.06±0.47 (% wb) of moisture, fat, crude protein, ash, crude fiber and carbohydrate, respectively. The mineral content of flour was 29.43±0.00, 5.87±1.36 and 2.56±0.04 mg 100 g” 1 of calcium, iron, and zinc, respectively. The essential amino acids profile of total flour proteins compared favourably with the FAO/WHO reference pattern except for deficiency of sulfo amino acids (methionine and sistin) with concentration of 9.72 mg g1 crude protein. The flours have potential as flour alternatives for food product development.
A Method for Detecting Interaction between 3D Hands and Unknown Objects in RGB Video
Authors: Wu Yankun , Wang Peipei , Wang Xin , Liu Guanqun , Zhao Lin , Xiang Ji 
Published: April 2021

Abstract
We propose a model that can extract 3D position of hand and object in per-frame of RGB videos through a single feed-forward neural network and a zero-shot learning classifier, and understand unknown hand-object interactions in the entire video through an interactive temporal module. The process is trained end-to-end, without depth images or annotated coordinates as input, which has good application prospects in real life.
A secure multicast routing algorithm Based on distributed PCE in multi-domain optical networks
Authors: Zhou Yang , Wu Qiwu , Jiang Lingzhi 
Published: April 2021

Abstract
Aiming at the calculation of secure multicast routing in multi-domain optical network, a new secure multicast routing algorithm based on distributed path calculation element was proposed. Firstly, the distributed PCE multicast routing model was constructed, and the intra-domain cost, inter-domain cost, maximum available wavelength and related constraints were defined. Secondly, the pheromone update strategy of ant colony algorithm with ant queen was locally simplified and modified to make it suitable for the distributed PCE architecture of multi-domain optical network. At the same time, by optimizing the trust value calculation method in the lightweight cross domain trust model, the algorithm can be applied to the calculation of trust value of multicast routing in multi domain optical networks. Finally, the specific implementation steps of the algorithm were given. The analysis and experimental results show that the algorithm can not only ensure the security of cross domain multicast routing, but also prevent the malicious nodes from destroying. Compared with the typical multicast routing algorithm, it has better performance in multicast tree cost and blocking rate in malicious node environment.
Automation of Calculations of Physical Deterioration of Elements of Residential Buildings
Authors: Kuripta O V , Vorob’eva Yu A , Minakova O V 
Published: April 2021

Abstract
The article raises the urgent problem of automating the process of calculating and assessing the physical deterioration of buildings, which is the most important indicator characterizing the physical condition of the building in quantitative terms and of interest to realtors and management companies. In this regard, the authors proposed and developed a software module that allows you to calculate and evaluate the physical depreciation of buildings in accordance with departmental standards, which reduces the complexity and reduces the process of assessing physical depreciation. When working with the software module, the user is provided with the following functionalities: selection of the studied elements of the system, background information on the signs of their wear, automatic calculation of physical wear and reporting on the received assessment.
Urban Square Covering as the Environmental Design Element
Authors: Shipilov A G , Zaichikov R S , Ponomarenko N V 
Published: April 2021

Abstract
The article presents complementary synthesis method. It is necessary for students to form design thinking when designing urban environment. The method is revealed through mutually complementary aspects: social aspect and the aspect of objective filling of architectural environment. Social aspect develops through research and context analysis. Architectural, aesthetic and culturological requirements were taken into consideration. Psychological features of an individual when perceiving small architectural objects were also taken into consideration. The aspect of objective filling of architectural environment is presented by 3D modeling approach. The objectives of compositional design, engineering and technology were taken into consideration. Synthesis is revealed in a creative act of developing objects of environmental design. It is the environmental design that puts the interiors of streets and public gardens into cultural shapes creating a kind of “design-space”. The method of including the requirements of Russian Federation regulations on the area into the design work has been shown. Modeling resulted in draft design of urban square covering meeting the involved requirements.
MINTyper: an outbreak-detection method for accurate and rapid SNP typing of clonal clusters with noisy long reads
Authors: Hallgren Malte B , Overballe-Petersen Søren , Lund Ole , Hasman Henrik , Clausen Philip T L C 
Published: April 2021

Abstract
For detection of clonal outbreaks in clinical settings, we present a complete pipeline that generates a single-nucleotide polymorphisms-distance matrix from a set of sequencing reads. Importantly, the program is able to handle a separate mix of both short reads from the Illumina sequencing platforms and long reads from Oxford Nanopore Technologies’ (ONT) platforms as input. MINTyper performs automated reference identification, alignment, alignment trimming, optional methylation masking, and pairwise distance calculations. With this approach, we could rapidly and accurately cluster a set of DNA sequenced isolates, with a known epidemiological relationship to confirm the clustering. Functions were built to allow for both high-accuracy methylation-aware base-called MinION reads (hac_m Q10) and fast generated lower-quality reads (fast Q8) to be used, also in combination with Illumina data. With fast Q8 reads a higher number of base pairs were excluded from the calculated distance matrix, compared with the high-accuracy methylation-aware Q10 base-calling of ONT data. Nonetheless, when using different qualities of ONT data with corresponding input parameters, the clustering of isolates were nearly identical.
Sequence-specific inhibition of reverse transcription by recombinant CRISPR/dCas13a ribonucleoprotein complexes in vitro
Authors: Fujita Toshitsugu , Nagata Shoko , Yuno Miyuki , Fujii Hodaka 
Published: April 2021

Abstract
The clustered regularly interspaced short palindromic repeats (CRISPR) system is widely used for genome editing because of its ability to cleave specific DNA sequences. Recently, RNA-specific CRISPR systems have been reported. CRISPR systems, consisting of a guide RNA (gRNA) and a nuclease-dead form of Cas13a (dCas13a), can be used for RNA editing and visualization of target RNA. In this study, we examined whether a recombinant CRISPR/dCas13a ribonucleoprotein (RNP) complex could be used to inhibit reverse transcription (RT) in a sequence-specific manner in vitro. Recombinant Leptotrichia wadei dCas13a was expressed using the silkworm-baculovirus expression system and affinity-purified. We found that the CRISPR/dCas13a RNP complex, combined with a chemically synthesized gRNA sequence, could specifically inhibit RT of EGFR and NEAT1, but not nonspecific RNA. Thus, the CRISPR/dCas13a RNP complex can inhibit RT reactions in a sequence-specific manner. RT inhibition by the CRISPR/dCas13a system may be useful to assess target binding activity, to discriminate RNA species retaining target sequences of gRNA, or to suppress RT from undesirable RNA species.