bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differentiation between fresh and frozen‐thawed scallop adductor muscle as raw materials for sashimi during cold storage
Authors: Niu Yabin , Dong Shiliang , Shimakage Naoto , Wei Huamao , Yu Kefeng , Yuan Chunhong , Takaki Koichi 
Published: November 2021

AbstractThe changes of sensory and biochemical characteristics on the fresh and frozen‐thawed scallop adductor muscle during storage at 4°C were discussed in this study. The Quality Index Method (QIM) scheme for evaluating scallop adductor muscle as raw materials for sashimi was proposed for the first time. The results of sensory evaluation showed that frozen‐thawed scallop adductor muscle within zero to one day of refrigeration can be happily accepted by consumers, indicating the superiority of freezing for long‐distance transportation, although the triangle test confirmed that there are still sensorial differences between fresh and frozen‐thawed scallop adductor muscle. The microscopic observation of myofibrils extracted from scallop adductor muscle suggested that the myofibrillar protein which constitutes myofibrils has suffered some extent change due to freezing and thawing, even though the head region of myosin remained stable judging by the fact that there was no significant difference in Ca2+‐ATPase activity (p > 0.05). The changes of adenosine triphosphate (ATP) and its related compounds, and pH value during storage can be regarded as indicators to differentiate fresh and frozen‐thawed scallop adductor muscle. The changes of Mg2+‐ATPase activity indicated that the interaction between myosin and actin was weakened by the freezing and thawing process.Practical Application: The QIM scheme can be used to evaluate the scallop adductor muscle as raw materials for sashimi. The mechanism of quality changes in the frozen‐thawed scallop adductor muscle was discussed in combination with the destruction of myofibrils, ATP degradation and the decrease of pH value. This study has positive significance for improving the quality of frozen‐thawed scallop adductor muscle by combining the changes of sensory and biochemical characteristics.
Cariprazine‐induced mania: A case series report
Authors: Pons‐Cabrera María T. , Palacios‐Garrán Roberto , Tardón‐Senabre Laia , Fernández‐Plaza Tabatha , Marco‐Estrada Oriol , Madero Santiago , Anmella Gerard , Colomer Lluc , Druetta Mauro , Giménez‐Palomo Anna , Navarro‐Cortés Lourdes , Sagué‐Vilavella María , Sánchez‐Sierra Carlos , Verdolini Norma , Catalan Rosa , Bioque Miquel , Goikolea Jose M. , Vieta Eduard , Pacchiarotti Isabella 
Published: November 2021

AbstractBipolar depression is the most prevalent phase of bipolar disorder (BD). There is a risk of inducing treatment‐emergent affective switches (TEAS) with antidepressants (ADs). Hence, clinical guidelines do not recommend their use in monotherapy. Cariprazine is a dopamine‐serotonin partial agonist, with a recent FDA approval as a monotherapy for BD type 1 (BD‐I) depression. To our knowledge, there is no significant evidence of cariprazine‐induced TEAS in bipolar depression. We describe three clinical cases of patients admitted to our acute psychiatric ward who developed manic episodes after the introduction of low doses of cariprazine. Two of the patients met the DSM‐5 criteria for BD‐I, and one for schizoaffective disorder, bipolar type. All patients were initially treated with low doses of cariprazine (1.5 mg) during a depressive phase. All three cases were simultaneously treated with mood stabilizers, regardless of which they switched to a manic episode when cariprazine was initiated. In our review of previous studies assessing the efficacy and side effects profile of cariprazine in BD‐I, TEAS have not been found to be significant. However, according to our experience, cariprazine may induce affective switches in BD‐I patients. Patients and psychiatrists should receive information regarding early warning symptoms and monitor possible cariprazine‐induced mood switching.
Association of tacrolimus time‐to‐therapeutic range on renal dysfunction and acute cellular rejection after orthotopic heart transplantation in a high use basiliximab population
Authors: Nanni Alexis N. , Harris Matthew , Watson Mara , Yang Zidanyue , Lee Hui‐Jie , DeVore Adam D. , Henderson James B. 
Published: November 2021

AbstractBackgroundCurrently, clinicians often delay initiation of tacrolimus after orthotopic heart transplantation (OHT) to help mitigate nephrotoxicity. This study aimed to determine if there is an association between the time‐to‐therapeutic range (TTT) of tacrolimus, early renal dysfunction, and acute cellular rejection (ACR) after OHT.MethodsThis was a retrospective, single center study with adult patients who underwent OHT from July 2013 to April 2020. Logistic regression analysis was utilized to examine the association of TTT with new renal dysfunction after tacrolimus initiation post‐OHT.ResultsIn a study of 317 patients, the unadjusted analysis showed patients who developed new renal dysfunction after tacrolimus initiation had a numerically shorter TTT (9.5 vs. 11.0 days, P = .065), and were more likely to have supratherapeutic tacrolimus levels (56% vs. 39.2%, P = .010). When adjusted for established risk factors for renal dysfunction, TTT was significantly associated with new renal dysfunction (OR .95; 95% CI [.90, .99], P = .03). There was no association between TTT and the incidence of ACR (11.1 vs. 10.8 days, P = .64).ConclusionWhen adjusting for known risk factors, a shorter TTT was associated with new renal dysfunction. Supratherapeutic tacrolimus levels were also associated with new renal dysfunction. There was no association between TTT and ACR in the setting of high use basiliximab induction.
Face–hand sensorimotor interactions revealed by afferent inhibition
Authors: Ramalho Bia Lima , Moly Julien , Raffin Estelle , Bouet Romain , Harquel Sylvain , Farnè Alessandro , Reilly Karen T. 
Published: November 2021

AbstractReorganization of the sensorimotor cortex following permanent (e.g., amputation) or temporary (e.g., local anaesthesia) deafferentation of the hand has revealed large‐scale plastic changes between the hand and face representations that are accompanied by perceptual correlates. The physiological mechanisms underlying this reorganization remain poorly understood. The aim of this study was to investigate sensorimotor interactions between the face and hand using an afferent inhibition transcranial magnetic stimulation protocol in which the motor evoked potential elicited by the magnetic pulse is inhibited when it is preceded by an afferent stimulus. We hypothesized that if face and hand representations in the sensorimotor cortex are functionally coupled, then electrocutaneous stimulation of the face would inhibit hand muscle motor responses. In two separate experiments, we delivered an electrocutaneous stimulus to either the skin over the right upper lip (Experiment 1) or right cheek (Experiment 2) and recorded muscular activity from the right first dorsal interosseous. Both lip and cheek stimulation inhibited right first dorsal interosseous motor evoked potentials. To investigate the specificity of this effect, we conducted two additional experiments in which electrocutaneous stimulation was applied to either the right forearm (Experiment 3) or right upper arm (Experiment 4). Forearm and upper arm stimulation also significantly inhibited the right first dorsal interosseous motor evoked potentials, but this inhibition was less robust than the inhibition associated with face stimulation. These findings provide the first evidence for face‐to‐hand afferent inhibition.
Structural and functional brain networks of individual differences in trait anger and anger control: An unsupervised machine learning study
Authors: Sorella Sara , Vellani Valentina , Siugzdaite Roma , Feraco Paola , Grecucci Alessandro 
Published: November 2021

AbstractThe ability to experience, use and eventually control anger is crucial to maintain well‐being and build healthy relationships. Despite its relevance, the neural mechanisms behind individual differences in experiencing and controlling anger are poorly understood. To elucidate these points, we employed an unsupervised machine learning approach based on independent component analysis to test the hypothesis that specific functional and structural networks are associated with individual differences in trait anger and anger control. Structural and functional resting state images of 71 subjects as well as their scores from the State–Trait Anger Expression Inventory entered the analyses. At a structural level, the concentration of grey matter in a network including ventromedial temporal areas, posterior cingulate, fusiform gyrus and cerebellum was associated with trait anger. The higher the concentration, the higher the proneness to experience anger in daily life due to the greater tendency to orient attention towards aversive events and interpret them with higher hostility. At a functional level, the activity of the default mode network (DMN) was associated with anger control. The higher the DMN temporal frequency, the stronger the exerted control over anger, thus extending previous evidence on the role of the DMN in regulating cognitive and emotional functions in the domain of anger. Taken together, these results show, for the first time, two specialized brain networks for encoding individual differences in trait anger and anger control.
Spherical fuzzy extension of AHP‐ARAS methods integrated with modified k‐means clustering for logistics hub location problem
Authors: Gocer Fethullah , Sener Nazmi 
Published: November 2021

AbstractLike most other industries, logistics services are currently encountering enormous transformation. Many companies worldwide are applying big data analytics to implement operational strategies and facilitate location selection. Logistics companies need to focus on now and explore some futures of logistics hub location problems. Creating a profitable logistic network is a crucial task for airline and postal services. To establish a cost‐effective network, transportation expenses should be decreased, and networks should be simplified. Hub location problem is born out of these needs. The concept of hub cumulates the flows and makes networks more reliable. In this article, a novel hub location selection approach is introduced in a group decision making (GDM) environment with uncertainty by integrating a modified weighted k‐means clustering algorithm with multi‐criteria decision‐making (MCDM) tools. The combined MCDM method integrates analytic hierarchy process (AHP) to measure criteria weights and Additive Ratio Assessment technique to measure the performance of hub location alternatives in a spherical fuzzy set (SFS) environment. The SFS has shown definite advantages in handling vagueness and uncertainty over crisp, fuzzy, or intuitionistic fuzzy sets to depict experts' evaluations with a richer structure, allowing for more representative decision making. Using Turkish logistics data, big data algorithm facilitates 15 possible locations, and these sites are ranked in order by the integrated GDM methodology. The validation of the proposed evaluation model is illustrated in an application of the network structure in Turkey. Finally, sensitivity and comparison evaluations are introduced to demonstrate the feasibility and effectiveness of the proposed approach.
Plague risk in the western United States over seven decades of environmental change
Authors: Carlson Colin J. , Bevins Sarah N. , Schmid Boris V. 
Published: November 2021

AbstractAfter several pandemics over the last two millennia, the wildlife reservoirs of plague (Yersinia pestis) now persist around the world, including in the western United States. Routine surveillance in this region has generated comprehensive records of human cases and animal seroprevalence, creating a unique opportunity to test how plague reservoirs are responding to environmental change. Here, we test whether animal and human data suggest that plague reservoirs and spillover risk have shifted since 1950. To do so, we develop a new method for detecting the impact of climate change on infectious disease distributions, capable of disentangling long‐term trends (signal) and interannual variation in both weather and sampling (noise). We find that plague foci are associated with high‐elevation rodent communities, and soil biochemistry may play a key role in the geography of long‐term persistence. In addition, we find that human cases are concentrated only in a small subset of endemic areas, and that spillover events are driven by higher rodent species richness (the amplification hypothesis) and climatic anomalies (the trophic cascade hypothesis). Using our detection model, we find that due to the changing climate, rodent communities at high elevations have become more conducive to the establishment of plague reservoirs—with suitability increasing up to 40% in some places—and that spillover risk to humans at mid‐elevations has increased as well, although more gradually. These results highlight opportunities for deeper investigation of plague ecology, the value of integrative surveillance for infectious disease geography, and the need for further research into ongoing climate change impacts.
Invasive versus conservative strategy in the very elderly with non‐ST‐elevation acute coronary syndrome: A meta‐analysis of randomized controlled trials
Authors: Wang Haiyan , Shi Liye , Tian Wen , Zhao Shijie 
Published: November 2021

AimTo investigate the optimal treatment strategy in patients older than 80 years with non‐ST‐segment elevation acute coronary syndrome (NSTE‐ACS).MethodsAll published randomized, placebo‐controlled trials (RCTs) reporting on comparisons between invasive and conservative strategies for patients aged 80 years or older with NSTE‐ACS were identified. The literature search was performed using PubMed, EMBASE, Cochrane Library, and the ISI Web of Science, from their establishment to July 2021 with no language restriction. The pooled risk ratios (RRs) with 95% confidence intervals (CI) for dichotomous outcomes were calculated.ResultsThree RCTs involving a total of 893 cases met the inclusion criteria. Compared with the conservative group, the invasive strategy could significantly improve the incidence rate of composite endpoint (I2 = 21.9%; RR 0.727, 95% CI 0.619 to 0.855, P < 0.001), recurrent myocardial infarction (MI) (I2 = 0.0%; RR 0.585, 95% CI 0.441 to 0.776, P < 0.001) and revascularization (I2 = 0.0%; RR 0.239, 95% CI 0.126 to 0.455, P < 0.001). However, no benefits were observed on outcomes of all‐cause death (I2 = 0.0%; RR 0.888, 95% CI 0.681 to 1.160, P = 0.384), cardiac death (I2 = 0.0%; RR 0.769, 95% CI 0.412 to 1.433, P = 0.408) and stroke (I2 = 0.0%; RR 0.778, 95% CI 0.392 to 1.543, P = 0.473). The major bleeding events were comparable between the two groups (I2 = 0.0%; RR 1.582, 95% CI 0.622 to 4.025, P = 0.336).ConclusionsCompared with a conservative strategy, the invasive treatment could reduce the incidence of composite endpoint, recurrent MI, and revascularization in the very elderly with NSTE‐ACS. However, no benefits were observed on mortality. Geriatr Gerontol Int 2022; 22: 36–41.
Some characteristics of clinical sequelae of COVID‐19 survivors from Wuhan, China: A multi‐center longitudinal study
Authors: Chen Xian , Li Ying , Shao Tong‐Ren , Yang Ling‐Li , Li Si‐Jing , Wang Xiu‐Juan , Li Ao , Wu Yin‐Yu , Liu Xue‐Fei , Liu Chun‐Mei , Liu Yu‐Hui , Zeng Fan , Cen Yuan 
Published: November 2021

AbstractBackgroundThe pandemic of COVID‐19 has a persistent impact on global health, yet its sequelae need to be addressed at a wide scale around the globe. This study aims to investigate the characteristics, prevalence, and risk factors for mid‐term (>6 months) clinical sequelae in a cohort of COVID‐19 survivors.MethodsTotally 715 COVID‐19 survivors discharged before April 1, 2020, from three medical centers in Wuhan, China, were included. The longitudinal study was conducted by telephone interviews based on a questionnaire including the clinical sequelae of general, respiratory, and cardiovascular systems. Demographics and some characteristics of clinical sequelae of the survivors were recorded and analyzed. Multivariate logistic regression analysis was applied to explore the risk factors for the sequelae.ResultsThe median time interval from discharge to telephone interview was 225.0 days. The COVID‐19 survivors' median ages were 69 years, and 51.3% were male. Among them, 29.9% had at least one clinical sequela. There were 19.2%, 22.7%, and 5.0% of the survivors reporting fatigue, respiratory symptoms, and cardiovascular symptoms, respectively. Comorbidities, disease severity, the application of mechanical ventilation and high‐flow oxygen therapy, and the history of re‐admission were associated with the presence of clinical sequelae.ConclusionsOur study provides further evidence for the prevalence and characteristics of clinical sequelae of COVID‐19 survivors, suggesting long‐term monitoring and management is needed for their full recovery.
Improvement of anti‐erosion performance of TiN coatings through using a filtration cathode vacuum arc deposition method
Authors: He Guangyu , Wang Li , Chen Jiao , Sun Danyang , Chai Yan , Fang Zhihao 
Published: November 2021

AbstractSand erosion is a major factor that shortens the service life of aircraft in desert regions. The anti‐erosion performance of titanium alloys may be improved using TiN coatings. However, few studies have employed Ti sputtering on Ti transition layers to improve the erosion resistance of the coatings. Herein, TiN coatings with a sputtering layer between the Ti transition layer and the TiN layer were deposited on a Ti–6Al–4V alloy by filtered cathodic vacuum arc deposition. For comparison, another group of TiN coatings without a Ti sputtering layer but processed using the same deposition parameters were prepared. The effects of the nanoscale sputtering layer on the microstructure, mechanical properties, and anti‐erosion performance of the coatings were investigated using scanning electron microscopy, transmission electron microscopy, X‐ray diffraction, and nanoindentation. The results show that the introduction of a Ti sputtering layer promoted the growth of TiN grains, leading to the formation of finer and denser TiN columnar grains. The preferred orientation of the coatings with the sputtering layer is (111) plane, whereas that of the coatings without the sputtering layer is (200) plane. The TiN coatings containing a sputtering layer exhibit higher hardness, elastic modulus, and H3/E2 ratio, which enhances the anti‐erosion performance of the coatings. The coatings with a sputtering layer exhibited better erosion resistance (erosion rate reduced by 75%) than the coatings without a sputtering layer. The underlying mechanism to understand the effect of the sputtering layer on the erosion resistance was discussed based on variations in the microstructure and mechanical properties of the coatings with and without the Ti sputtering layer. Ti sputtering layer was finally proved to be an effective method to improve the erosion resistance of TiN coatings.
Plant endophytic bacteria: A potential resource pool of electroactive micro-organisms
Authors: Ling Lijun , Yang Caiyun , Li Zibin , Luo Hong , Feng Shenglai , Zhao Yunhua , Lu Lu 
Published: November 2021

Abstract

Aims
Electroactive micro-organisms play a significant role in microbial fuel cells. It is necessary to discover potential resources in plant endophytes. In this study, plant tissues were selected to isolate endophytic bacteria, and the electrochemical activity potential was evaluated.

Methods and results
The microbial fuel cell (MFC) is used to evaluate the electricity-producing activity of endophytic bacteria in plant tissues, and the species distribution of micro-organisms in the anode of the MFC after inoculation of plant tissues is determined by high-throughput sequencing. Twenty-six strains of bacteria were isolated from plant tissues belonging to Angelica and Sweet Potato, of which 17 strains from six genera had electrochemical activity, including Bacillus sp., Pleomorphomonas sp., Rahnella sp., Shinella sp., Paenibacillus sp. and Staphylococcus sp. Moreover, the electricity-producing micro-organisms in the plant tissue are enriched. Pseudomonas and Clostridioides are the dominant genera of MFC anode inoculated with angelica tissue. Staphylococcus and Lachnoclostridium are the dominant genera in MFC anode inoculated with sweet potato tissue. And the most representative Gram-positive strain Staphylococcus succinus subsp. succinus H6 and plant tissue were further analysed for electrochemical activity. And a strain numbered H6 and plant tissue had a good electrogenerating activity.

Conclusion
This study is of great significance for expanding the resource pool of electricity-producing micro-organisms and tapping the potential of plant endophytes for electricity-producing.

Significance and Impact of Study
This is the first study to apply plant endophytes to MFC to explore the characteristics of electricity production. It is of great significance for exploring the diversity of plant endophytes and the relationship between electricity producing bacteria and plants.
Molecular insights into psychedelic drug action
Authors: Slocum Samuel T. , DiBerto Jeffrey F. , Roth Bryan L. 
Published: November 2021

AbstractA confluence of factors has renewed interest in the scientific understanding and translational potential of psychedelic drugs such as lysergic acid diethylamide (LSD), mescaline, and psilocybin: the desire for additional approaches to mental health care, incremental progress in basic and clinical research, and the reconsideration and relaxation of existing drug policies. With the United States Food and Drug Administration's designation of psilocybin as a “Breakthrough Therapy” for treatment‐resistant depression, a new path has been forged for the conveyance of psychedelics to the clinic. Essential to the further development of such applications, however, is a clearer understanding of how these drugs exert their effects at the molecular level. Here we review the current knowledge regarding the molecular details of psychedelic drug actions and suggest that these discoveries can facilitate new insights into their hallucinogenic and therapeutic mechanisms.
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Roles of eukaryotic elongation factor 2 kinase (eEF2K) in neuronal plasticity, cognition, and Alzheimer disease
Authors: Ma Tao 
Published: November 2021

AbstractUnderstanding the molecular signaling mechanisms underlying cognition and neuronal plasticity would provide insights into the pathogenesis of neuronal disorders characterized by cognitive syndromes such as Alzheimer disease (AD). Phosphorylation of the mRNA translational factor eukaryotic elongation factor 2 (eEF2) by its specific kinase eEF2K is critically involved in protein synthesis regulation. In this review, we discussed recent studies on the roles of eEF2K/eEF2 signaling in the context of regulation/dysregulation of cognitive function and synaptic plasticity. We specifically focus on the discussion of recent evidence indicating suppression of eEF2K signaling as a potential novel therapeutic avenue for AD and related dementias (ADRDs).image