bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accounting for the Temporal Fluctuation of Wind Power Production When Assessing Their Environmental Impacts with LCA: Combining Wind Power with Power-to-Gas in Denmark
Authors: Besseau Romain , Dhorne Milien , Pérez-López Paula , Blanc Isabelle 
Published: October 2021

AbstractWorldwide wind power capacity is increasing, while the environmental footprint and economic cost of energy produced decrease. However, wind power generation is weather-dependent. At a high penetration rate, storage systems such as power-to-gas may become necessary to adjust electricity production to consumption. This research work presents the environmental life cycle performance of wind power accounting for the energy storage induced by the temporal variability of weather-dependent production and consumption. A case study in which wind power installations are combined with a power-to-gas system in Denmark to provide electricity according to the national load consumption profile was considered. Results highlight an increase, roughly by a factor 2, of the carbon footprint coming from both energy storage infrastructure and induced losses, but remain significantly, at least ten times, lower than fossil counterparts.
Empirisches Vorgehen
Authors: Albisser Matthias 
Published: October 2021

ZusammenfassungDie vorliegende Arbeit hat zum Ziel, herauszufinden, wie sich informativer und unterhaltender Brand Content auf Markenimagedimensionen auswirkt Im vorherigen Kapitel wurde der aktuelle Forschungsstand mit Bezug zu dieser Frage diskutiert. Bestehende Forschung hat gezeigt, dass die Wirkung von Brand Content auch vom Kommunikationskanal und von der Art Marke, die den Brand Content ausspielt, abhängt.
Bulk locality for scalars and fermions with global symmetry
Authors: Chowdhury Subham Dutta , Ghosh Kausik 
Published: October 2021

Abstract
We count the number of independent solutions to crossing constraints of four point functions involving charged scalars and charged fermions in a CFT with large gap in the spectrum. To find the CFT data we employ recently developed analytical functionals to charged fields. We compute the corresponding higher dimensional flat space S matrices in an independent group theoretic manner and obtain agreement with our CFT counting of ambiguities. We also write down the local lagrangians explicitly. Our work lends further evidence to [1] that any CFT with a large central charge expansion and a large gap in the spectrum has an AdS bulk dual.
General null asymptotics and superrotation-compatible configuration spaces in d ≥ 4
Authors: Capone F. 
Published: October 2021

Abstract
We address the problem of consistent Campiglia-Laddha superrotations in d > 4 by solving Bondi-Sachs gauge vacuum Einstein equations at the non-linear level with the most general boundary conditions preserving the null nature of infinity. We discuss how to generalise the boundary structure to make the configuration space compatible with supertanslation-like and superrotation-like transformations. One possibility requires the time-independent boundary metric on the cuts of "Image missing" to be non-Einstein, while the other sticks to Einstein but time-dependent metrics. Both are novel features with respect to the four dimensional case, where time-dependence of the two-dimensional cross-sectional metric is not required and the Einstein condition is trivially satisfied. Other cases are also discussed. These conditions imply that the configuration spaces are not asymptotically flat in the standard sense. We discuss the implications on the construction of the phase space and the relationship with soft scattering theorems. We show that in even spacetime dimensions, the initial data compatible with such asymptotic symmetries produce maximally polyhomogeneous expansions of the metric and we advance a potential interpretation of this structure in terms of AdS/CFT and realizations of Ricci-flat holography.
The Na+-activated K+ channel Slack contributes to synaptic development and plasticity
Authors: Matt Lucas , Pham Thomas , Skrabak David , Hoffmann Felix , Eckert Philipp , Yin Jiaqi , Gisevius Miriam , Ehinger Rebekka , Bausch Anne , Ueffing Marius , Boldt Karsten , Ruth Peter , Lukowski Robert 
Published: October 2021

AbstractHuman mutations of the Na+-activated K+ channel Slack (KCNT1) are associated with epilepsy and intellectual disability. Accordingly, Slack knockout mice (Slack−/−) exhibit cognitive flexibility deficits in distinct behavioral tasks. So far, however, the underlying causes as well as the role of Slack in hippocampus-dependent memory functions remain enigmatic. We now report that infant (P6–P14) Slack−/− lack both hippocampal LTD and LTP, likely due to impaired NMDA receptor (NMDAR) signaling. Postsynaptic GluN2B levels are reduced in infant Slack−/−, evidenced by lower amplitudes of NMDAR-meditated excitatory postsynaptic potentials. Low GluN2B affected NMDAR-mediated Ca2+-influx, rendering cultured hippocampal Slack−/−neurons highly insensitive to the GluN2B-specific inhibitor Ro 25-6981. Furthermore, dephosphorylation of the AMPA receptor (AMPAR) subunit GluA1 at S845, which is involved in AMPAR endocytosis during homeostatic and neuromodulator-regulated plasticity, is reduced after chemical LTD (cLTD) in infant Slack−/−. We additionally detect a lack of mGluR-induced LTD in infant Slack−/−, possibly caused by upregulation of the recycling endosome-associated small GTPase Rab4 which might accelerate AMPAR recycling from early endosomes. Interestingly, LTP and mGluR LTD, but not LTD and S845 dephosphorylation after cLTD are restored in adult Slack−/−. This together with normalized expression levels of GluN2B and Rab4 hints to developmental “restoration” of LTP expression despite Slack ablation, whereas in infant and adult brain, NMDAR-dependent LTD induction depends on this channel. Based on the present findings, NMDAR and vesicular transport might represent novel targets for the therapy of intellectual disability associated with Slack mutations. Consequently, careful modulation of hippocampal Slack activity should also improve learning abilities.
Spectral Asymptotics for Kinetic Brownian Motion on Surfaces of Constant Curvature
Authors: Kolb Martin , Weich Tobias , Wolf Lasse L. 
Published: October 2021

AbstractThe kinetic Brownian motion on the sphere bundle of a Riemannian manifold $$\mathbb {M}$$
M
is a stochastic process that models a random perturbation of the geodesic flow. If $$\mathbb {M}$$
M
is an orientable compact constantly curved surface, we show that in the limit of infinitely large perturbation the $$L^2$$

L
2

-spectrum of the infinitesimal generator of a time-rescaled version of the process converges to the Laplace spectrum of the base manifold.
The Strongly Coupled Polaron on the Torus: Quantum Corrections to the Pekar Asymptotics
Authors: Feliciangeli Dario , Seiringer Robert 
Published: October 2021

AbstractWe investigate the Fröhlich polaron model on a three-dimensional torus, and give a proof of the second-order quantum corrections to its ground-state energy in the strong-coupling limit. Compared to previous work in the confined case, the translational symmetry (and its breaking in the Pekar approximation) makes the analysis substantially more challenging.
Digital breast tomosynthesis (DBT) plus synthesised two-dimensional mammography (s2D) in breast cancer screening is associated with higher cancer detection and lower recalls compared to digital mammography (DM) alone: results of a systematic review and meta-analysis
Authors: Heywang-Köbrunner Sylvia H. , Jänsch Alexander , Hacker Astrid , Weinand Sina , Vogelmann Tobias 
Published: October 2021

Abstract
Objectives
Digital breast tomosynthesis (DBT) plus digital mammography (DM) in screening is problematic due to increased radiation by the double exposure. Synthesised two-dimensional mammography (s2D) calculated from DBT datasets at no additional dose appears a sensible alternative compared to adding DM. This systematic review and meta-analysis focuses on screening performance outcomes in women screened with DBT plus s2D compared to DM alone.

Methods
PubMed was searched from January 1, 2010, to September 2, 2020. Studies comparing DBT plus s2D to DM alone in breast cancer screening were included. Pooled risk ratios (RR) were estimated for cancer detection rates (CDR), recall rates, interval cancer rates (ICR), biopsy rates, and positive predictive values for recalls (PPV-1), for biopsies recommended (PPV-2), and for biopsies performed (PPV-3). Sensitivity analyses were performed using the leave-one-out approach. Risk of bias (RoB) was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS)-2 tool.

Results
Twelve papers covering 414,281 women were included from 766 records identified. CDR is increased ([RR, 95% CI] 1.35, 1.20–1.52), recall rates are decreased (0.79, 0.64–0.98), and PPV-1 is increased (1.69, 1.45–1.96) when using DBT plus s2D compared to DM alone. ICR and biopsy rates did not differ, but PPV-2 respectively PPV-3 increased with DBT plus s2D (1.57, 1.08–2.28 respectively 1.36, 1.17–1.58). Overall RoB of studies was assessed to be low.

Conclusion
Results show improved diagnostic outcomes with DBT plus s2D compared to DM alone and underline the value of DBT in combination with s2D in breast cancer screening.

Key Points
• DBT plus s2D is associated with higher CDR, lower recall rates, and a higher PPV-1 compared to DM alone in breast cancer screening.
• No differences in biopsy rates were found between screening modalities, but PPV-2 and PPV-3 were higher in women screened with DBT plus s2D compared to DM alone.
• We identified inconsistent results of ICR in two studies comparing DBT plus s2D to DM alone—resulting in no differences when pooling ICR in meta-analysis.
Early response of right-ventricular function to percutaneous mitral valve repair
Authors: Sugiura Atsushi , Shamekhi Jasmin , Goto Tadahiro , Spieker Maximilian , Iliadis Christos , Kavsur Refik , Mauri Victor , Kelm Malte , Baldus Stephan , Tanaka Tetsu , Tabata Noriaki , Sinning Jan-Malte , Weber Marcel , Zimmer Sebastian , Nickenig Georg , Westenfeld Ralf , Pfister Roman , Becher Marc Ulrich ,   of the Heart Failure Network Rhineland
Published: October 2021

Abstract
Background
The change in right-ventricular function (RVF) after transcatheter mitral valve repair is still poorly understood. We assessed the early response of RVF to the MitraClip procedure and its clinical relevance.

Methods
We analyzed consecutive patients who underwent a MitraClip procedure to treat MR between August 2010 and March 2019 in the Heart Failure Network Rhineland registry. RVF was assessed before and after the procedure. Impaired RVF was defined as an RV fractional area change (RVFAC) < 35% or tricuspid annular plane systolic excursion (TAPSE) < 16 mm.

Results
816 eligible patients (77 ± 9 years, 58.5% male) were included in the analysis. Baseline values of RVF were: RVFAC 38.6 (IQR 29.7–46.7) % and TAPSE 17.0 (IQR 14.0–21.0) mm. At a median time of 3 (IQR 2–5) days after the procedure, the RVF remained normal in 34% (n = 274), normalized in 17% (n = 140), deteriorated in 15% (n = 125), and was persistently impaired in 34% (n = 277) of patients. The RVF response was significantly associated with a composite outcome of all-cause mortality and hospitalization due to heart failure within a 2-year follow-up. Compared to stable/normal RVF, the adjusted hazard ratios for the outcome were 1.78 (95% CI 1.10–2.86) for normalized RVF, 1.89 (95% CI 1.34–3.15) for deteriorated RVF, and 2.25 (95% CI 1.47–3.44) for persistently impaired RVF. Changes in TAPSE and RVFAC as continuous variables were significantly correlated with the outcome.

Conclusion
An early change in RVF following transcatheter mitral valve repair is predictive of mortality and hospitalization due to heart failure during follow-up.

Graphic abstract
Early response of RVF after MitraClip and its clinical significance. An acute, early change in RVF can be observed following the MitraClip procedure, which is associated with the risk of mortality and hospitalization for HF.
Return-sweep saccades in oral reading
Authors: Adedeji Victoria I. , Vasilev Martin R. , Kirkby Julie A. , Slattery Timothy J. 
Published: October 2021

AbstractRecent research on return-sweep saccades has improved our understanding of eye movements when reading paragraphs. However, these saccades, which take our gaze from the end of one line to the start of the next line, have been studied only within the context of silent reading. Articulatory demands and the coordination of the eye–voice span (EVS) at line boundaries suggest that the execution of this saccade may be different in oral reading. We compared launch and landing positions of return-sweeps, corrective saccade probability and fixations adjacent to return-sweeps in skilled adult readers while reading paragraphs aloud and silently. Compared to silent reading, return-sweeps were launched from closer to the end of the line and landed closer to the start of the next line when reading aloud. The probability of making a corrective saccade was higher for oral reading than silent reading. These indicate that oral reading may compel readers to rely more on foveal processing at the expense of parafoveal processing. We found an interaction between reading modality and fixation type on fixation durations. The reading modality effect (i.e., increased fixation durations in oral compared to silent reading) was greater for accurate line-initial fixations and marginally greater for line-final fixations compared to intra-line fixations. This suggests that readers may use the fixations adjacent to return-sweeps as natural pause locations to modulate the EVS.
Aneurismal subarachnoid hemorrhage during the COVID-19 outbreak in a Hub and Spoke system: observational multicenter cohort study in Lombardy, Italy
Authors: Fiorindi Alessandro , Vezzoli Marika , Doglietto Francesco , Zanin Luca , Saraceno Giorgio , Agosti Edoardo , Barbieri Antonio , Bellocchi Silvio , Bernucci Claudio , Bongetta Daniele , Cardia Andrea , Costi Emanuele , Egidi Marcello , Fioravanti Antonio , Gasparotti Roberto , Giussani Carlo , Grimod Gianluca , Latronico Nicola , Locatelli Davide , Mardighian Dikran , Nodari Giovanni , Poli Jacopo Carlo , Rasulo Frank , Roca Elena , Sicuri Giovanni Marco , Spena Giannantonio , Stefini Roberto , Vivaldi Oscar , Zoia Cesare , Calza Stefano , Fontanella Marco Maria , Cenzato Marco 
Published: October 2021

Abstract
Background
Lombardy was the most affected Italian region by the first phase of the COVID-19 pandemic and underwent urgent reorganization for the management of emergencies, including subarachnoid hemorrhage from a ruptured cerebral aneurysm (aSAH). The aim of the study was to define demographics, clinical, and therapeutic features of aSAH during the COVID-19 outbreak and compare these with a historical cohort.

Methods
In this observational multicenter cohort study, patients aged 18 years or older, who were diagnosed with aSAH at the participating centers in Lombardy from March 9 to May 10, 2020, were included (COVID-19 group). In order to minimize bias related to possible SAH seasonality, the control group was composed of patients diagnosed with aSAH from March 9 to May 10 of the three previous years, 2017–2018-2019 (pre-pandemic group). Twenty-three demographic, clinical, and therapeutic features were collected. Statistical analysis was performed.

Results
Seventy-two patients during the COVID-19 period and 179 in the control group were enrolled at 14 centers. Only 4 patients were positive for SARS-CoV-2. The “diagnostic delay” was significantly increased (+ 68%) in the COVID-19 group vs. pre-pandemic (1.06 vs. 0.63 days, respectively, p-value = 0.030), while “therapeutic delay” did not differ significantly between the two periods (0.89 vs. 0.74 days, p-value = 0.183). Patients with poor outcome (GOS at discharge from 1 to 3) were higher during the COVID-19 period (54.2%) compared to pre-pandemic (40.2%, p = 0.044). In logistic regression analysis, in which outcome was the dichotomized Glasgow Outcome Scale (GOS), five variables showed p-values < 0.05: age at admission, WFNS grade, treatment (none), days in ICU, and ischemia.

Conclusions
We documented a significantly increased “diagnostic delay” for subarachnoid hemorrhages during the first COVID-19 outbreak in Lombardy. However, despite the dramatic situation that the healthcare system was experiencing, the Lombardy regional reorganization model, which allowed centralization of neurosurgical emergencies such as SAHs, avoided a “therapeutic delay” and led to results overall comparable to the control period.
Psychological well-being in people with multiple sclerosis: a descriptive review of the effects obtained with mindfulness interventions
Authors: Di Cara Marcella , Grezzo Denise , Palmeri Rosanna , Lo Buono Viviana , Cartella Emanuele , Micchia Katia , Formica Caterina , Rifici Carmela , Sessa Edoardo , D’Aleo Giangaetano , Maresca Giuseppa , Bramanti Placido , Corallo Francesco 
Published: October 2021

AbstractMultiple sclerosis is a neuroinflammatory and neurodegenerative disease causing several psychosocial problems that significantly impairs quality of life. The most common physical and mental symptoms are anxiety, depression, stress, fatigue, and pain. Several studies investigated the effectiveness of non-pharmacological approaches in improving psychological well-being. This review focused on the impact of mindfulness interventions in patients with multiple sclerosis to reduce psychopathological symptoms and improve well-being. We searched on PubMed database and screening references of included studies and review articles for additional citations. From initial 107 studies, only 8 met search criteria. Our studies showed the efficacy of mindfulness treatment with a reduction in depressive symptoms, a better quality of life (both mental and physical), and a decreased level of fatigue. Findings demonstrated that mindfulness is useful for the improvement of psychological symptoms and pain management and this improvement has also been shown to have a positive impact on the quality of life and coping and adaptation strategies. However, according to the poor available clinics evidence, on cannot conclude that mindfulness interventions are superior to other active interventions in the treatment of psychological symptoms of SM.
HIV Serostatus Disclosure Among Men Who Have Sex with Men in China in the Era of U=U and PrEP
Authors: Cao Wangnan , Li Jinghua , Sun Shengzhi , Sturm Carla , Peng Liping , Gu Jing , Hao Chun , Hou Fengsu , Wei Dannuo , You Xinyi , Deng Yang , Ekström Anna Mia 
Published: October 2021

AbstractGiven the recent evidence on “Undetectable = Untransmittable” (U=U) and pre-exposure prophylaxis (PrEP), the present study aimed to investigate HIV disclosure behaviors and their associations with sexual risk behaviors and U=U and PrEP awareness among men who have sex with men (MSM) in China. A cross-sectional survey was conducted among 689 MSM recruited through a gay-friendly non-governmental organization located in Chengdu, China in 2018–2019. Information was collected by a structured self-administrated questionnaire. The enrolled sample included 554 (80.4%) participants who were HIV-negative and 135 (19.6%) participants with an unknown HIV status. In terms of disclosure, 41.4% of participants informed all partners about their HIV status all the time (informing behavior), while 30.4% asked all partners about their HIV status all the time (asking behavior). Only one-fifth knew about U=U, but this was not statistically associated with either informing or asking behavior. Half (50.5%) had heard of PrEP but this was not statistically associated with either informing or asking behavior. Common barriers to informing and asking behaviors were lower risk perception of HIV infection, a history of sexually transmitted infections, engagement in receptive sex, and a history of sex with casual partners. We found that both U=U and PrEP awareness and HIV serostatus disclosure were infrequent and not associated in this study of Chinese MSM. These data indicate huge information gaps among MSM in China.
The learning-consciousness connection
Authors: Birch Jonathan , Ginsburg Simona , Jablonka Eva 
Published: October 2021

AbstractThis is a response to the nine commentaries on our target article “Unlimited Associative Learning: A primer and some predictions”. Our responses are organized by theme rather than by author. We present a minimal functional architecture for Unlimited Associative Learning (UAL) that aims to tie to together the list of capacities presented in the target article. We explain why we discount higher-order thought (HOT) theories of consciousness. We respond to the criticism that we have overplayed the importance of learning and underplayed the importance of spatial modelling. We decline the invitation to add a negative marker to our proposed positive marker so as to rule out consciousness in plants, but we nonetheless maintain that there is no positive evidence of consciousness in plants. We close by discussing how UAL relates to development and to its material substrate.
Vasomotor symptoms in midlife women with incident breast cancer: pink SWAN
Authors: Gold Ellen B. , Crawford Sybil L. , Leung Katherine , Greendale Gail , Reeves Katherine W. , Joffe Hadine , Avis Nancy E. 
Published: October 2021

Abstract
Purpose
We compared trajectories of vasomotor symptoms (VMS) and their risk factors in women with breast cancer (BrCa) to those of cancer-free controls.

Methods
Data were from 15 nearly annual follow-up visits (1996–2017) of the multi-racial/ethnic cohort of midlife women enrolled in the Study of Women’s Health Across the Nation (SWAN). We compared women with incident BrCa to controls for patterns of VMS, controlling for risk factors identified in bivariate analyses using multivariable longitudinal analyses.

Results
Characteristics at study entry largely did not differ between cases (n = 151) and controls (n = 2161). Adjusted prevalence of any VMS increased significantly among cases from diagnosis to 2.75 years post diagnosis [per-year adjusted odds ratio (aOR) = 1.76, 95% confidence interval (CI) 1.39–2.24], peaking at 2.75 years post diagnosis, whereas prevalence was stable among controls in this interval [aOR = 1.04, 95% CI 0.99–1.11]. Beyond 2.75 years post diagnosis, prevalence declined significantly in cases [aOR = 0.72, 95% CI 0.61–0.84] and less in controls [aOR = 0.96, 95% CI 0.92–1.00]. Patterns were similar for frequent VMS. Adjustment for tamoxifen use slightly reduced the per-year OR for any prevalent VMS post diagnosis, partially explaining excess VMS in cases. Other treatments were unassociated with VMS.

Conclusions
Patterns of prevalent VMS reporting differed significantly between cases and controls, particularly post diagnosis, the latter only partially explained by tamoxifen use among cases. Risk factors for VMS largely did not differ between cases and controls.