bluuebunny/crossref_metadata_2025_split huggingface dataset:
“At least someone thinks I’m doing well”: a real-world evaluation of the quit-smoking app StopCoach for lower socio-economic status smokers
Authors: Meijer Eline , Korst Janneke S. , Oosting Kristiene G. , Heemskerk Eline , Hermsen Sander , Willemsen Marc C. , van den Putte Bas , Chavannes Niels H. , Brown Jamie 
Published: July 2021

Abstract
Background
Smoking is more prevalent and persistent among lower socio-economic status (SES) compared with higher-SES groups, and contributes greatly to SES-based health inequities. Few interventions exist that effectively help lower-SES smokers quit. This study evaluated “De StopCoach”, a mobile phone delivered eHealth intervention targeted at lower-SES smokers based on the evidence-based StopAdvisor, in a real-world setting (five municipalities) in The Netherlands in 2019–2020.

Method
We conducted individual semi-structured interviews with project leaders, healthcare professionals, and participating smokers (N = 22), and examined log data from the app (N = 235). For practical reasons, SES of app users was not measured. Qualitative data were analysed using the Framework Approach, with the Consolidated Framework for Implementation Research (CFIR) and Unified Theory of Acceptance and Use of Technology (UTAUT) as theoretical models.

Results
Qualitative data showed that factors from the Intervention and Setting domains were most important for the implementation. StopCoach seemed suitable for lower-SES smokers in terms of performance and effort expectancy, especially when integrated with regular smoking cessation counseling (SCC). Key barriers to implementation of the app were limited integration of the app in SCC programs in practice, difficulty experienced by project leaders and healthcare professionals to engage the local community, and barriers to SCC more generally (e.g., perceived resistance to quitting in patients) that prevented healthcare professionals from offering the app to smokers. Quantitative data showed that 48% of app users continued using the app after the preparation phase and pre-quit day, and that 33% of app users had attempted to quit. Both app adherence and quit attempts were more likely if smokers also received SCC from a professional coach. Posthoc analyses suggest that adherence is related to higher likelihood of a quit attempt among participants with and without a professional coach.

Conclusions
Smokers, healthcare professionals and project leaders indicated in the interviews that the StopCoach app would work best when combined with SCC. It also appears from app log that app adherence and quit attempts by app users can be facilitated by combining the app with face-to-face SCC. As such, blended care appears promising for helping individual smokers quit, as it combines the best of regular SCC and eHealth. Further research on blended care for lower-SES smokers is needed.
Resveratrol protects human nucleus pulposus cells from degeneration by blocking IL-6/JAK/STAT3 pathway
Authors: Wu Cenhao , Ge Jun , Yang Ming , Yan Qi , Wang Yingjie , Yu Hao , Yang Huilin , Zou Jun 
Published: July 2021

Abstract
Background
Nucleus pulposus cells’ (NPCs’) degeneration is mainly responsible for the intervertebral disc degeneration (IDD), which is closely related to inflammatory response. Among the major proinflammatory factors that are related to NPCs’ degeneration, interleukin-6 (IL-6) and its downstream JAK/STAT3 pathway have received recent attention. The goal of our study is to figure out whether or how resveratrol (RSV) can protect NPCs from degeneration by affecting IL6/JAK/STAT3 pathway.

Methods
Different concentrations of RSV were added to NPCs’ mediums. Cell viability was measured by MTT assay and crystal violet staining. Cell cycle and apoptosis were analyzed by flow cytometry. Protein expression level was determined by western blot. mRNA expression level was measured by qPCR.

Results
Our study showed that RSV improved NPCs’ cell viability. It also inhibited cell apoptosis and cell cycle arrest, which were accompanied by the increased expression level of heat shock protein 90 (HSP90) and N-Cadherin. What’ more, RSV also improved the NPCs’ degeneration which was reflected in the increase of extracellular matrix (collagen II, Aggrecan). Moreover, RSV significantly attenuated the level of IL-6 secretion, which was accompanied by less phosphorylation of the transcription factors Janus kinase 1 (JAK1) and signal transducer and activator of transcription 3 (STAT3).

Conclusion
RSV exerted its protective effect on HNPCs’ degeneration by improving cell survival and function. The possible mechanism may be associated with the suppression of JAK/STAT3 phosphorylation and the decreased IL-6 production, which could be explained by a blockage of the positive feedback control loop between IL-6 and JAK/STAT3 pathway.
A novel physics-based and data-supported microstructure model for part-scale simulation of laser powder bed fusion of Ti-6Al-4V
Authors: Nitzler Jonas , Meier Christoph , Müller Kei W. , Wall Wolfgang A. , Hodge N. E. 
Published: July 2021

AbstractThe elasto-plastic material behavior, material strength and failure modes of metals fabricated by additive manufacturing technologies are significantly determined by the underlying process-specific microstructure evolution. In this work a novel physics-based and data-supported phenomenological microstructure model for Ti-6Al-4V is proposed that is suitable for the part-scale simulation of laser powder bed fusion processes. The model predicts spatially homogenized phase fractions of the most relevant microstructural species, namely the stable $$\beta $$
β
-phase, the stable $$\alpha _{\text {s}}$$

α
s

-phase as well as the metastable Martensite $$\alpha _{\text {m}}$$

α
m

-phase, in a physically consistent manner. In particular, the modeled microstructure evolution, in form of diffusion-based and non-diffusional transformations, is a pure consequence of energy and mobility competitions among the different species, without the need for heuristic transformation criteria as often applied in existing models. The mathematically consistent formulation of the evolution equations in rate form renders the model suitable for the practically relevant scenario of temperature- or time-dependent diffusion coefficients, arbitrary temperature profiles, and multiple coexisting phases. Due to its physically motivated foundation, the proposed model requires only a minimal number of free parameters, which are determined in an inverse identification process considering a broad experimental data basis in form of time-temperature transformation diagrams. Subsequently, the predictive ability of the model is demonstrated by means of continuous cooling transformation diagrams, showing that experimentally observed characteristics such as critical cooling rates emerge naturally from the proposed microstructure model, instead of being enforced as heuristic transformation criteria. Eventually, the proposed model is exploited to predict the microstructure evolution for a realistic selective laser melting application scenario and for the cooling/quenching process of a Ti-6Al-4V cube of practically relevant size. Numerical results confirm experimental observations that Martensite is the dominating microstructure species in regimes of high cooling rates, e.g., due to highly localized heat sources or in near-surface domains, while a proper manipulation of the temperature field, e.g., by preheating the base-plate in selective laser melting, can suppress the formation of this metastable phase.
Cisplatin-induced hydroxyl radicals mediate pro-survival autophagy in human lung cancer H460 cells
Authors: Sumkhemthong Somruethai , Prompetchara Eakachai , Chanvorachote Pithi , Chaotham Chatchai 
Published: July 2021

Abstract
Background
Accumulated evidence demonstrates cisplatin, a recommended chemotherapy, modulating pro-survival autophagic response that contributes to treatment failure in lung cancer patients. However, distinct mechanisms involved in cisplatin-induced autophagy in human lung cancer cells are still unclear.

Results
Herein, role of autophagy in cisplatin resistance was indicated by a decreased cell viability and increased apoptosis in lung cancer H460 cells pre-incubated with wortmannin, an autophagy inhibitor, prior to treatment with 50 µM cisplatin for 24 h. The elevated level of hydroxyl radicals detected via flow-cytometry corresponded to autophagic response, as evidenced by the formation of autophagosomes and autolysosomes in cisplatin-treated cells. Interestingly, apoptosis resistance, autophagosome formation, and the alteration of the autophagic markers, LC3-II/LC3-I and p62, as well as autophagy-regulating proteins Atg7 and Atg3, induced by cisplatin was abrogated by pretreatment of H460 cells with deferoxamine, a specific hydroxyl radical scavenger. The modulations in autophagic response were also indicated in the cells treated with hydroxyl radicals generated via Fenton reaction, and likewise inhibited by pretreatment with deferoxamine.

Conclusions
In summary, the possible role of hydroxyl radicals as a key mediator in the autophagic response to cisplatin treatment, which was firstly revealed in this study would benefit for the further development of novel therapies for lung cancer.
Background and descriptive features of rabies-suspected animals in Central Luzon, Philippines
Authors: Mananggit Milagros R. , Kimitsuki Kazunori , Saito Nobuo , Garcia Alyssa Marie G. , Lacanilao Patricia Mae T. , Ongtangco Joely T. , Velasco Cornelio R. , Rosario Maria Victoria D. , Lagayan Maria Glofezita O. , Yamada Kentaro , Park Chun-Ho , Inoue Satoshi , Suzuki Motoi , Saito-Obata Mariko , Kamiya Yasuhiko , Manalo Daria L. , Demetria Catalino S. , Quiambao Beatriz P. , Nishizono Akira 
Published: July 2021

Abstract
Background
The Philippines is one of the major endemic countries for canine rabies in Southeast Asia. However, detailed description and analysis of laboratory-confirmed animal rabies are limited. Highly accurate surveillance requires a thorough understanding of the target area-specific problems and obstacles. Therefore, we aim to describe and analyze the rabies suspect animals in Central Luzon, Philippines, to clarify the characteristics of management and clinical signs by conducting interviews with the owners.

Methods
We prospectively collected information on the rabies suspect animals submitted to the Regional animal laboratory in Central Luzon through passive laboratory-based rabies surveillance between 1st April 2019 and 30th September 2020. We performed active interviews directly or telephonically with the owner. The direct fluorescent antibody test was performed on the hippocampus, brain stem, and cerebellum for laboratory confirmation. Descriptive statistics were used to characterize the number of rabies cases according to management methods and characteristics of suspected animals during the observation period. Clinical symptoms of suspected rabid animals were analyzed by univariate logistic regression analysis.

Results
There were 292 sample submissions during the study period. Of these, 160 were positive for dFAT. Samples of pet animals (85.3%) provided by owners or their acquaintances (59.2%) accounted for the majority of laboratory confirmed cases. Case mapping showed that more rabies-suspected cases were sent from areas near the regional laboratory than from those far from the laboratory, despite the incidence of rabies being high in these areas. The management and clinical symptoms of 227 animal cases showed that most owners were managing their animals at home and were allowing them to roam outside (69.6%) and be unvaccinated (78.9%). Rabid animals were more likely to manifest aimless running, restlessness, and agitation.

Conclusions
Our study provided some features of animals with laboratory-confirmed rabies in Central Luzon. However, most of the samples were submitted from areas near the rabies diagnosis laboratory, and the number of samples submitted from remote areas was low. To improve the surveillance capacity, it is necessary to increase sample submissions from remote areas.
Provenance of sediments from Barra del Tordo and Tesoro beaches, Tamaulipas State, northwestern Gulf of Mexico
Authors: Ramos-Vázquez Mayla A. , Armstrong-Altrin John S. 
Published: July 2021

AbstractThe mineralogy, bulk sediment geochemical composition, and U–Pb ages of detrital zircons retrieved from the Barra del Tordo (Tordo) and Tesoro beach sediments in the northwestern Gulf of Mexico were analyzed to determine their provenance. The beach sediments are mainly composed of quartz, ilmenite, magnetite, titanite, zircon, and anorthite. The weathering proxies such as the Chemical Index of Alteration (CIA), Chemical Index of Weathering (CIW), and Plagioclase Index of Alteration (PIA), reveal a moderate-to-high intensity of weathering in the source area. The chondrite-normalized rare earth element (REE) patterns are similar to felsic igneous rocks, with large negative europium anomaly (Eu/Eu* = ~ 0.47–0.80 and ~ 0.57–0.67 in the Tordo and Tesoro beach sediments, respectively).Three major zircon U–Pb age groups are identified in the Tordo and Tesoro beach sediments, i.e., Proterozoic (~ 2039–595 Ma), Mesozoic (~ 244–70.3 Ma), and Cenozoic (~ 65.9–1.2 Ma). The differences of the zircon age spectrum between the Tordo and Tesoro beach sediments are not significant. The comparison of zircon U–Pb ages in this study with ages of potential source terranes suggests that the Mesozoic and Cenozoic zircons of the studied Tordo and Tesoro beach sediments were derived from the Eastern Alkaline Province (EAP) and Mesa Central Province (MCP). Similarly, the likely sources for the Proterozoic zircons were the Sierra Madre Oriental (SMOr) and Oaxaquia in the northwestern Gulf of Mexico. The results of this study further indicate that the sediments delivered to the beaches by rivers and redistributed by longshore currents were crucial in determining the sediment provenance.
Survey of ethnobotanical cocktails commonly used in the treatment of malaria in southwestern Nigeria
Authors: Omagha Rachel , Idowu Emmanuel Taiwo , Alimba Chibuisi Gideon , Otubanjo Adetoro Olubunmi , Adeneye Adeniyi Kazeem 
Published: July 2021

Abstract
Background
Combination of different antimalarials has become the popular method of care for malaria morbidity in conventional and traditional treatment approaches due to the need to increase the efficacy and reduce the selection of drug resistance. A worrisome concern is the critical gaps with regards to the information available on antimalarial herbal cocktails. This study presents cocktail herbal remedies in ethnomedicinal approaches to malaria treatment in Oyo and Ogun states, South West Nigeria. Ethnobotanical information on indigenous antimalarials used in combination remedies was collected from herbal practitioners using a semi-structured questionnaire.

Results
Findings showed majority of respondents treat malaria with combination herbal remedies. They sighted their beliefs and customs, the efficacy, affordability and availability of these herbs as reasons for their adoption of herbal medicines as their preferred mode of treating malaria. Enquiry revealed 26 sets of cocktail antimalarials from a variety of plant species. The plants and ingredients are extracted and used as decoction, infusion or steam baths. Oral route was the most popular mode of administration. Respondents reported they drink one to two medium-sized cups of the recipe on an average of two times daily within a duration of about 10 days.

Conclusions
Herbal antimalarial remedies continue to be the popular treatments option in our localities. This study provides knowledge of the diverse ways respondents combine medicinal herbs and other local ingredients for malaria treatment. Pharmacological screening is urgently needed to validate their safety and efficacy in order to protect the health of our locals heavily relying on them to combat high burdens of malaria.
Cervicofacial lymphatic malformations: diagnosis and management
Authors: Bouatay Rachida , Hmida Badii , Hajjej Malek , Farhati Amira , Harrathi Khaled , Kolsi Naourez , Koubaa Jamel 
Published: July 2021

Abstract
Background
Lymphatic malformations are rare benign tumors that result from congenital and acquired alterations of the lymphatic vessels. They occur most commonly on the head and neck region.
The aim of this study is to describe clinical profiles of lymphatic malformations of the head and neck (LMHN) as well as to study therapeutic modalities through our series and review of the literature.

Results
This is a retrospective record-based descriptive study conducted in the ENT and the Radiology departments over a 17-year period. Our study included twelve patients, aged between 8 months and 52 years. Two swellings were present at birth and had not been prenatally diagnosed in both cases. One patient was affected by TRISOMY 21.
All patients consulted for a painless mass of the head or neck. Seven masses were located in the suprahyoid region and five in the infrahyoid region. Ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI) were realized to establish the diagnosis and assess the extent of the lesions.
Surgical excision was performed in 7 patients. It was complete in 6 patients. Five patients were treated with sclerotherapy. The sclerosing agents used were Aetoxisclerol 2%, hypertonic saline, and absolute alcohol. One patient had a reversible paresis of the left mental nerve after surgery. An excellent response to sclerotherapy with complete resolution was obtained in 3 cases with no recurrence of the disease.

Conclusions
Surgical excision has been the management option of choice for LMHN. The recent advances in sclerotherapy make it safe and effective as a primary treatment modality for these lesions.
Post-stroke aphasia rehabilitation using computer-based Arabic software program: a randomized controlled trial
Authors: Elhakeem Engy Samy , Saeed Sabah Saeed Gommaa Mohamed , Elsalakawy Ramy Nabil Abd-Elkader , Elmaghraby Reham Mohamed , Ashmawy Ghada Abdel Hady Ossman 
Published: July 2021

Abstract
Background
Aphasia is considered an acquired communication disorder. Language intervention in aphasia enhances the patient outcomes. Recently, computer programs are developed for the treatment of aphasia. It is an effective and a low-cost therapy choice. The aim of the study was to assess the effectiveness of language therapy using a computer-based Arabic software program for rehabilitation of post-stroke Arabic-speaking aphasic patients in comparison to the conventional language therapy. We conducted a randomized controlled trial with blinded endpoint evaluation. The trial included 50 aphasic patients. They were randomized into either group I or group II to receive 48 therapy sessions using the Arabic software program (group I) or the conventional therapy (group II). The primary outcome was a measure of improvement in language abilities. It was measured using the Arabic version of the Boston Diagnostic Aphasia Examination to detect any significant improvement in the language of both groups in comparison to pre-therapy results. The post-therapy results of both groups were compared to each other to document the effectiveness of the software program.

Results
A total of 105 aphasic patients were screened and 50 subjects were randomized to the intervention groups [40 subjects were males, mean age of the patients: 57.04 years± SD 10.88 for group I and 58.80 years ± SD 11.58 for group II]. The therapy results showed a significant improvement from the baseline in both groups. There was no significant difference in the post-therapy results between group I and group II except for some items whereas group I showed more significant improvement.

Conclusions
Language therapy using a computer-based Arabic software program was as effective as the conventional therapy in the improvement of language abilities of Arabic-speaking aphasic patients.
Interferometric body-wave retrieval from ambient noise after polarization filtering: Application to shallow reflectivity imaging
Authors: Dangwal Deepankar , Behm Michael 
Published: July 2021

Interferometric retrieval of body waves from ambient noise recorded at surface stations is usually challenged by the dominance of surface-wave energy, in particular in settings dominated by anthropogenic activities (e.g., natural resource exploitation, traffic, and infrastructure construction). As a consequence, ambient noise imaging of shallow structures such as sedimentary layers remains a difficult task for sparse and irregularly distributed receiver networks. We have determined how polarization filtering can be used to automatically extract steeply inclined compressional waves (P-waves) from continuous 3C recordings, and, in turn, it improves passive body-wave imaging. Being a single-station approach, the technique does not rely on a dense receiver array and is therefore well suited for data collected during surveillance monitoring for tasks such as reservoir hydraulic stimulation, CO2 sequestration, and wastewater disposal injection. We apply the method on a continuous data set acquired in the Wellington oilfield (Kansas, US), where local and regional seismicity and other forms of ambient noise provide an abundant source of surface- and body-wave energy recorded at 15 short-period receivers. We use autocorrelation (AC) to derive the shallow (<1 km) reflectivity structure below the receiver array and validate our workflow and results with well logs and active seismic data. Ray-tracing analysis and waveform modeling indicate that converted shear waves need to be taken into account for realistic ambient noise body-wave source distributions because they can be projected on the vertical component and might lead to misinterpretation of the P-wave reflectivity structure. Overall, our study suggests that polarization filtering significantly improves passive body-wave imaging on AC and interstation crosscorrelation. It reduces the impact of time-varying noise source distributions and is therefore also potentially useful for time-lapse ambient noise interferometry.
Telehealth in Oncology: ASCO Standards and Practice Recommendations
Authors: Zon Robin T. , Kennedy Erin B. , Adelson Kerin , Blau Sibel , Dickson Natalie , Gill David , Laferriere Nicole , Lopez Ana Maria , Mulvey Therese M. , Patt Debra , Pickard Todd A. , Purdom Terry , Royce Trevor J. , Sumrall Ashley L. , Page Ray D. 
Published: July 2021

PURPOSE To provide standards and practice recommendations specific to telehealth in oncology. METHODS A systematic review of the literature on telehealth in oncology was performed, including the use of technologies and telecommunications systems, and other electronic methods of care delivery and sharing of information with patients. The evidence base was combined with the opinion of the ASCO Telehealth Expert Panel to develop telehealth standards and guidance. Public comments were solicited and considered in preparation of the final manuscript. RESULTS The Expert Panel determined that general guidance on implementing telehealth across general and specialty settings has been published previously and these resources are endorsed. A systematic search for studies on topics specific to oncology resulted in the inclusion of two clinical practice guidelines, 12 systematic reviews, and six primary studies. STANDARDS AND GUIDANCE Standards and guidance are provided for which patients in oncology can be seen via telehealth, establishment of the doctor-physician relationship, role of allied health professionals, role of advanced practice providers, multidisciplinary cancer conferences, and teletrials in oncology. Additional information is available at www.asco.org/standards .