bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Pulsed Electromagnetic Field Therapy at Different Frequencies on Bone Mass and Microarchitecture in Osteoporotic Mice
Authors: Wang Liqiong , Li Yi , Xie Suhang , Huang Jinming , Song Kangping , He Chengqi 
Published: June 2021

A pulsed electromagnetic field (PEMF) can promote osteogenesis. However, studies have shown variation in the signal characteristics in terms of waveform type, intensity, frequency, and treatment duration. Among the factors that affect electromagnetic fields, frequency plays a major role. However, few studies have investigated the effects of PEMF at different frequencies in osteoporotic mice. Therefore, our objective was to determine the effect of PEMF frequency in osteoporotic mice. Forty 3‐month‐old female mice were randomly divided into the following five groups: sham, OVX, and OVX followed by 1.6‐mT PEMF exposure groups (8 Hz, 50 Hz, and 75 Hz, 1.6 mT). The PEMF was applied for 1 h/day, 7 days/week, for 4 weeks. After 4 weeks, the micro‐computed tomography showed that PEMF with (50 and 75 Hz) ameliorated the deterioration of bone microarchitecture. Improvements in the bone histological analysis were identified for PEMF with 50 and 75 Hz groups compared with the ovariectomy (OVX) controls. Osteoclast numbers were decreased in PEMF with (50 and 75 Hz). Moreover, the real‐time PCR demonstrated PEMF with (50 and 75 Hz) significantly promoted the expression of the osteoblast‐related genes (ALP, OCN, Runx2), and increased the serum PINP. PEMF with (50 and 75 Hz) exerted significant inhibitory effects on the osteoclast‐related mRNA expression (CTSK, NFATc1, TRAP) and bone resorption markers CTX‐I and IL‐1β. Taken together, our results showed that PEMF at 50 and 75 Hz with 1.6 mT significantly ameliorate the deterioration of bone microarchitecture in OVX mice. The inhibitory effect of PEMF may be associated with IL‐1β inhibition. © 2021 Bioelectromagnetics Society.
Synthesis, comparativein vitroantibacterial, antioxidant and UV fluorescence studies of bis indole Schiff bases and molecular docking with ct‐DNA and SARS‐CoV‐2 Mpro
Authors: Singhal Sugandha , Khanna Pankaj , Khanna Leena 
Published: June 2021

AbstractIn this study, synthesis of 15 novel bis indole‐based Schiff bases (SBs)4a–4owas conducted by condensation of 2‐(1‐aminobenzyl)benzimidazole with symmetrical bis‐isatins linked via five alkyl chains (n = 2–6). These were subjected to ADME (absorption, distribution, metabolism and excretion), physiochemical properties, molecular docking,in vitroantibacterial and antioxidant studies. The in silico studies indicated lower toxicity with metabolic stability for nearly all the derivatives proving reliability as drug candidates. The comparative antibacterial study againstStaphylococcus aureusandEscherichia coli, also showed a superior inhibition than reference drug and their mono counterparts. The increase in linker alkyl chain length and variation of substituents in indole, further predicted increased inhibition, with maximum value for compound4oat 50 μg/ml. Thein vitrocalf thymus DNA (ct‐DNA) binding ability of compounds4c, 4f, 4i, 4l, 4 m, 4n,and4owas evaluated via ultraviolet‐visible and fluorescence spectroscopy techniques. A hyperchromic effect was observed with no apparent wavelength shift which predicted for the groove binding mode. A moderate binding constant for4o, in fluorescence results, confirms groove binding. The molecular docking of4owith ct‐DNA (PDBID:1BNA) and SARS‐CoV‐2 Mpro(3CL protease, PDBID:6LU7) prove its efficacy as potential DNA binder and antiviral agent.
A resource orchestration view of supply chain traceability and transparency bundles for competitive advantage
Authors: Malik Mohsin , Ghaderi Hadi , Andargoli Amir 
Published: June 2021

AbstractThe literature has mostly examined supply chain (SC) traceability and SC transparency separately, ignoring the mutually constitutive relationship of these two related constructs. We draw on the resource orchestration theory and the causal complexity perspective to conceptualize and validate SC traceability and SC transparency as interrelated organizational capabilities that may mutually enhance or compensate each other for competitive advantage. We constructed an original sample from two sources to empirically test this conceptualization using fuzzy set qualitative comparative analysis (fsQCA). Our empirical results reveal that the ability of firms to leverage SC traceability for a high financial performance is contingent upon creating a transparency perception of SC with a wide range of stakeholders. Our results also identified the firm size and its international presence, as having a significant bearing on the ability of firms to leverage SC traceability and SC transparency capabilities for a competitive advantage.
The genomic landscape of teenage and young adult T‐cell acute lymphoblastic leukemia
Authors: Mansur Marcela B. , Furness Caroline L. , Nakjang Sirintra , Enshaei Amir , Alpar Donat , Colman Sue M. , Minto Lynne , Irving Julie , Poole Beth V. , Noronha Elda P. , Savola Suvi , Iqbal Sameena , Gribben John , Pombo‐de‐Oliveira Maria S. , Ford Tony M. , Greaves Mel F. , van Delft Frederik W. 
Published: June 2021

AbstractBackgroundTreatment on risk adapted intensive pediatric protocols has improved outcome for teenagers and young adults (TYA) with T‐cell acute lymphoblastic leukemia (T‐ALL). Understanding the biology of disease in this age group and the genetic basis of relapse is a key goal as patients with relapsed/refractory disease have poor outcomes with conventional chemotherapy and novel molecular targets are required. This study examines the question of whether TYA T‐ALL has a specific biological‐molecular profile distinct from pediatric or adult T‐ALL.MethodsGenomic characterization was undertaken of a retrospective discovery cohort of 80 patients aged 15–26 years with primary or relapsed T‐ALL, using a combination of Genome‐Wide Human SNP Array 6.0, targeted gene mutation and promoter methylation analyses. Findings were confirmed by MLPA, real‐time quantitative PCR, and FISH. Whole Exome Sequencing was performed in 4 patients with matched presentation and relapse to model clonal evolution. A prevalence analysis was performed on a final data set of 1,792 individual cases to identify genetic lesions with age specific frequency patterns, including 972 pediatric (1–14 years), 439 TYA (15–24 years) and 381 adult (≥25 years) cases. These cases were extracted from 19 publications with comparable genomic data identified through a PubMed search.ResultsGenomic characterization of this large cohort of TYA T‐ALL patients identified recurrent isochromosome 7q i(7q) in our discovery cohort (n = 3). Prevalence analysis did not identify any age specific genetic abnormalities. Genomic analysis of 6 pairs of matched presentation – relapsed T‐ALL established that all relapses were clonally related to the initial leukemia. Whole exome sequencing analysis revealed recurrent, targetable, mutations disrupting NOTCH, PI3K/AKT/mTOR, FLT3, NRAS as well as drug metabolism pathways.ConclusionsAll genetic aberrations in TYA T‐ALL occurred with an incidence similar or intermediate to that reported in the pediatric and adult literature, demonstrating that overall TYA T‐ALL exhibits a transitional genomic profile. Analysis of matched presentation – relapse supported the hypothesis that relapse is driven by the Darwinian evolution of sub‐clones associated with drug resistance (NT5C2 and TP53 mutations) and re‐iterative mutation of known key T‐ALL drivers, including NOTCH1.
Yinzhihuang Oral Liquid Ameliorates Hyperbilirubinemia Induced by δ‐Aminolevulinic Acid and Novobiocin in Neonatal Rats
Authors: Han Jing , Li Caiyu , Dai Zhi , Duan Juanhui , Cai Wen , Wang Yong , Zhang Youcai 
Published: June 2021

AbstractYinzhihuang oral liquid (YZH) is a traditional Chinese medicine that has been widely used in Asia to prevent and treat neonatal hyperbilirubinemia, but the published preclinical studies on its anti‐hyperbilirubinemia effect are conducted in adult animals, partly due to the lack of preclinical neonatal hyperbilirubinemia animal models. In the present study, we tested six reagents to induce hyperbilirubinemia in neonatal rats, and established two appropriate neonatal hyperbilirubinemia rat models by subcutaneous injection of δ‐Aminolevulinic acid (ALA, 200 mg/kg) or novobiocin (NOVO, 200 mg/kg). Oral treatment of YZH (80, 160 and 320 mg/kg) significantly decreased serum conjugated bilirubin levels in ALA‐treated neonatal rats and serum unconjugated bilirubin levels in NOVO‐treated neonatal rats, respectively. Additionally, pre‐treatment of YZH also prevented the increase of serum bilirubin levels in both ALA‐ and NOVO‐treated rats. Mechanistically, YZH significantly up‐regulated the mRNA expression of genes involved in hepatic bilirubin disposition (organic anion‐transporting polypeptide 1b2, Oatp1b2; multidrug resistance‐associated protein 2, Mrp2) and bilirubin conjugation (UDP‐glucuronosyltransferase 1a1, Ugt1a1). Additionally, YZH up‐regulated the mRNA expression of cytochrome P450 1A1 (Cyp1a1), the target gene of aryl hydrocarbon receptor (AhR), and increased the nuclear protein levels of AhR in livers of neonatal rats. YZH and its two active ingredients, namely baicalin (BCL) and 4’‐hydroxyacetophenone (4‐HT), up‐regulated the mRNA expression of AhR target genes (CYP1A1 and UGT1A1) and increased nuclear protein levels of AhR in HepG2 cells. In conclusion, the present study provides two neonatal hyperbilirubinemia animal models and evaluates the anti‐hyperbilirubinemia effect and mechanisms of YZH in neonatal animals.
Analysis of photoaging characteristics of Chinese traditional pigments and dyes in different environments based on color difference principle
Authors: Zhao Zining , Zhang Peng , Liu Xianming , Lei Xiaohua , Luo Yun 
Published: June 2021

AbstractPhotocatalytic oxidation is one of the main factors leading to the aging damage of Chinese traditional dyes and pigments. In this study, in order to analyze the photoaging characteristics of traditional dyes and pigments commonly used in Chinese cultural relics in different environments, we used traditional Chinese painting pigments to make colored paper samples, and used traditional dye extraction and dyeing technology to make colored silk samples. By setting up nitrogen and atmospheric chamber and using LED, tungsten halogen lamp, metal halide lamp and fluorescent lamp as light sources, an accelerated photoaging contrast test on 16 kinds of dyes and pigments was carried out, and then the color difference of different samples in different light environment and atmosphere environment was obtained. Through systematic analysis, the results show that the type of light source and the gas environment will affect the photoaging rate of the samples. The nitrogen environment can significantly reduce the degree and speed of photoaging, especially for organic dyes and pigments.
Nature‐inspired resource management and dynamic rescheduling of microservices in Cloud datacenters
Authors: Joseph Christina Terese , Chandrasekaran Kandasamy 
Published: June 2021

AbstractDistributed Cloud environments are now resorting to Cloud applications composed of heterogeneous microservices. Cloud service providers strive to provide high quality of service (QoS) and response time is one of the key QoS attributes for microservices. The dynamism of microservice ecosystems necessitates runtime adaptations and microservices rescheduling to avoid performance degradation. Existing works target rescheduling in hypervisor‐based systems, while ignoring the influence of configuration parameters of container‐based microservices. In an effort to address these challenges, this article describes a novel microservice rescheduling framework, throttling and interaction‐aware anticorrelated rescheduling for microservices, to proactively perform rescheduling activities whilst ensuring timely service responses. Based on periodic monitoring of the performance attributes, the framework schedules container migrations. Considering the exponentially large solution space, a metaheuristic approach based on multiverse optimization is developed to generate the near‐optimal mapping of microservices to the datacenter resources. Experimental results indicate that our framework provides superior performance with a reduction of up to 13.97% in the average response time, when compared with systems with no support for rescheduling.
Parallel compression for large collections of genomes
Authors: Yao Haichang , Chen Shuai , Liu Shangdong , Li Kui , Ji Yimu , Hu Guangyong , Wang Ruchuan 
Published: June 2021

SummaryWith the development of genome sequencing technology, the cost of genome sequencing is continuously reducing, while the efficiency is increasing. Therefore, the amount of genomic data has been increasing exponentially, making the transmission and storage of genomic data an enormous challenge. Although many excellent genome compression algorithms have been proposed, an efficient compression algorithm for large collections of FASTA genomes, especially can be used in the distributed system of cloud computing, is still lacking. This article proposes two optimization schemes based on HRCM compression method. One is MtHRCM adopting multi‐thread parallel technology. The other is HadoopHRCM adopting distributed computing parallel technology. Experiments show that the schemes recognizably improve the compression speed of HRCM. Moreover, BSC algorithm instead of PPMD algorithm is used in the new schemes, the compression ratio is improved by 20% compared with HRCM. In addition, our proposed methods also perform well in robustness and scalability. The Java source codes of MtHRCM and HadoopHRCM can be freely downloaded from
https://github.com/haicy/MtHRCM and
https://github.com/haicy/HadoopHRCM.
How corporate social responsibility initiatives affect the choice of a bank: Empirical evidence of Italian context
Authors: Lagasio Valentina , Cucari Nicola , Åberg Carl 
Published: June 2021

AbstractFor all firms, it is imperative to identify and understand the factors that influence consumers purchasing behaviors and, specifically, identify how customer demographics relate to corporate social responsibility (CSR) activities. However, limited research exists on banking consumer's preferences and responses towards different CSR initiatives. Therefore, using an exploratory survey consisting of 250 received responses of attitudes and perceptions from customers of Italian savings banks, we investigate the interactions between three types of CSR initiatives (ethical behavior towards the environment, social inclusion initiatives, and financing eco‐sustainable projects) and respondents' demographic characteristics. We predict that different types of CSR initiatives influence the choice of banking institution among customers with diverse demographic characteristics (age, geographic origin, and type of employment). This research helps in making several important contributions to CSR research which can assist banks in developing effective CSR strategies.
Low‐complexity linear precoding for low‐PAPR massive MU‐MIMO‐OFDM downlink systems
Authors: Zayani Rafik , Roviras Daniel 
Published: June 2021

SummaryTo design new revolutionary wireless communication systems, orthogonal frequency‐division multiplexing (OFDM)‐based massive multiuser (MU) multiple‐input multiple‐output (MIMO) has been shown to be the most promising technology to significantly enhance the spectral, energy, and hardware efficiencies. However, massive MU‐MIMO‐OFDM transmitters exhibit signal with high peak‐to‐average power ratio (PAPR). Accordingly, the nonlinearity of the radio frequency (RF) power amplifier (PA), which causes the most severe hardware impairment, is expected to be a low‐cost and energy‐efficient component to enable cost‐ and energy‐efficient massive MU‐MIMO‐OFDM BS deployments, generating harmful in‐band distortion and out‐of‐band (OOB) emissions. In this paper, we develop a PAPR‐aware downlink transmission scheme in an OFDM‐based large‐scale MU‐MIMO. Linear precoding of data and peak‐canceling signals (PCSs) are employed to reduce the PAPRs of the transmitted signals by exploiting the excess degrees of freedom (DoFs) provided by equipping the base station (BS) by a large number of transmit antennas. Specifically, we design PCSs to be added to the frequency‐domain precoded data signals, with the goal of reducing the PAPRs of their time‐domain counterpart signals. Most importantly, the added PCSs have to lie in the null spaces of their associated MIMO channel matrices such that they do not cause any MU interference (MUI) and OOB radiation. In this regard, an efficient algorithm is developed, which is based on different data and PCSs precoders, and the corresponding achievable PAPR reduction and bit error rate (BER) performance are analyzed. Moreover, to optimize a tradeoff between performance and complexity, linear precoders based on matrix polynomials (M‐POLYs) and gradient‐iterative approaches are studied for both data and PCSs precoding. Simulation results reveal that these latter provide similar performance as the regularized zero‐forcing (RZF) and orthogonal projection null space (OPNS)‐based data and PCSs precoders, while they need much lower computational complexity. The substantial PAPR reduction provided by the proposed algorithm offers interesting insights for the design of energy‐efficient massive MU‐MIMO‐OFDM systems.
Verification of a new metric for data flow continuity and sustainability optimization
Authors: Vondrous Ondrej , Kocur Zbynek , Hrad Jaromir 
Published: June 2021

SummaryThis article presents a verification process of a new metric designed for transmission continuity optimization. Unlike the commonly used metrics, it focuses solely on flow continuity and sustainability, disregarding the maximization of throughput or minimization of latency. We base our metric on inter‐packet gaps analysis and ordering of packets from multiple communication flows into a final flow. We also compare our metric with the commonly used one based on Jain's fairness index in cases when optimization of communication flow sustainability is the priority. We present the evaluation of results and analyze the data processing complexity. Moreover, we discuss the weaknesses and strengths of different approaches to communication flow optimization.
Termite mound cover and abundance respond to herbivore‐mediated biotic changes in a Kenyan savanna
Authors: Charles Grace K. , Riginos Corinna , Veblen Kari E. , Kimuyu Duncan M. , Young Truman P. 
Published: June 2021

AbstractBoth termites and large mammalian herbivores (LMH) are savanna ecosystem engineers that have profound impacts on ecosystem structure and function. Both of these savanna engineers modulate many common and shared dietary resources such as woody and herbaceous plant biomass, yet few studies have addressed how they impact one another. In particular, it is unclear how herbivores may influence the abundance of long‐lived termite mounds via changes in termite dietary resources such as woody and herbaceous biomass. While it has long been assumed that abundance and areal cover of termite mounds in the landscape remain relatively stable, most data are observational, and few experiments have tested how termite mound patterns may respond to biotic factors such as changes in large herbivore communities. Here, we use a broad tree density gradient and two landscape‐scale experimental manipulations—the first a multi‐guild large herbivore exclosure experiment (20 years after establishment) and the second a tree removal experiment (8 years after establishment)—to demonstrate that patterns in Odontotermes termite mound abundance and cover are unexpectedly dynamic. Termite mound abundance, but areal cover not significantly, is positively associated with experimentally controlled presence of cattle, but not wild mesoherbivores (15–1,000 kg) or megaherbivores (elephants and giraffes). Herbaceous productivity and tree density, termite dietary resources that are significantly affected by different LMH treatments, are both positive predictors of termite mound abundance. Experimental reductions of tree densities are associated with lower abundances of termite mounds. These results reveal a richly interacting web of relationships among multiple savanna ecosystem engineers and suggest that termite mound abundance and areal cover are intimately tied to herbivore‐driven resource availability.
A barcoding‐based scat‐analysis assessment of Eurasian otter Lutra lutra diet on Kinmen Island
Authors: Jang‐Liaw Nian‐Hong 
Published: June 2021

Abstract

While it is well known that Eurasian otters principally feed on fishes and crustaceans, their detailed diet taxonomies are not fully understood. This is partly due to their nocturnal behavior and the limited resolving power of traditional morphological identification from scat. A suitable, reliable molecular method for diet studies is therefore needed.

I performed a series of Sanger‐sequencing reactions, utilizing nine primer sets for Eurasian otter diet research. These are mainly based on the barcoding concept to determine the taxonomic composition of spraints. The primer sets target different types of animals, amplifying each separately. This procedure was used to detect the prey contents of 64 spraint samples collected from Kinmen Island. Through high‐resolution gel electrophoresis and sequencing, it was evident that PCR products could be successfully amplified by the different primer sets and from spraint samples comprising multiple prey species.

Extracted DNA from all spraint samples was PCR‐amplified with 9 primer sets. In total, 16 prey types were identified across all 64 samples. Fourteen were identified at the species level.

The aim of this study was to develop and apply a novel diet research method to Eurasian otters. Eight of the primers are universal primers designed for COI segments of different animal groups, and one primer set was designed specifically for tilapia groups. This method can be applied to study the diets of not only Kinmen Eurasian otter populations, but also other Eurasian otter populations and other small carnivorous animals.