bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the Impacts of Work, Non-Work and Stress Issues on the Work Family Conflict in Ivorian Industrial Sector
Authors: Choki Aristide Gbame , Zhao Qiuhong 
Published: May 2021

Abstract
This paper analyzes the perceptions that workers in the Ivorian industrial sector have as the interface between their professional and personal life, and the factors that facilitate or make it difficult. Data collected from 4 Ivorian industrial companies which represent a sample of 187 respondents according to the selection criteria. These collected data make it possible to identify the factors which act on the labor conflict towards the family as well as the factors which act on the family conflict towards the work within the industrial sector in Cte d’Ivoire. The results of the correlation coefficients show that the relationships between the proposed variables are significant and in the direction suggested for the most part, thus providing support for nine of the ten hypotheses affecting these relationships. According to some results obtained, it was discovered that certain factors could be at the same time, factors of conflict and satisfaction, such as the commitment to work or the nature of the work. These variables can simultaneously increase stress, and increase the self-esteem of the worker. The results of the analysis of the proposed model recommend the possibility that the data fit the model well, explaining the impacts of work, non-work and stressors on work-family conflict. This indicates that the proposed model is adapted to the Ivorian context.
A Case of Personalized Management of Carcinoma of Fallopian Tube Harboring BRCA Mutation and Sister Mary Joseph's Nodule
Authors: Chen Xi , Fu Yaoyao , Zhang Na , Li Yang , Zhang Min , wang guili 
Published: May 2021

Abstract
Fallopian tube malignancies have been presumed to rare incidence with dismal prognosis. However, recent data suggest that the true incidence of PFTC has been substantially underestimated. Early diagnosis of fallopian tube cancer seems difficult. The routes of metastasis of fallopian tube carcinoma are similar to those of ovarian cancer. Genetic factors are relatively important risk factors for tubal cancer. Poly ADP -ribose polymerase inhibitor is used for BRCA-mutant PFTC. In this artical, we use a rare case of navel metastatic tumor which finally be confirmed that it is originated from fallopian tube to discovered the hereditary factors through genetic testing, and reported this case to provide preventive intervention for the next generation of eugenics and incidence.
Evaluation of Four-Hand Reduction for Obturator Hernia with the Guidance of Sonography (FROGS) as a new treatment strategy for obturator hernia: A retrospective study
Authors: Togawa Yuki , Kamihata Kyohei , Nagahisa Yoshio , Kawamoto Kazuyuki 
Published: May 2021

Abstract
Purpose: Obturator hernias are uncommon but are important causes of intestinal obstruction. Delayed treatment can be fatal. Emergency surgery is considered the most effective treatment; however, patients with obturator hernia usually have comorbidities, and this precludes them from emergency surgery. This study aimed to evaluate the effectiveness of Four-hand Reduction for Obturator hernia with the Guidance of Sonography (FROGS) as a new treatment strategy for obturator hernia.Methods: Since November 2019, we have tried FROGS in all patients with obturator hernia at the emergency room. We retrospectively compared the clinical data of 14 patients who underwent FROGS (after-FROGS group) with those of 23 patients who did not (before-FROGS group).Results: All patients were females. There were no significant differences in age, lesion side, duration of symptoms, the diameter of the prolapsed bowel, and predisposing factors. The body mass index was significantly lower in the after-FROGS group than in the before-FROGS group. Manual reduction was successfully performed in all 14 patients in the FROGS group, whereas in the before-FROGS group, 14 patients underwent manual reduction, of whom only one was successfully treated using the non-FROGS method. Bowel resection was avoided in all 14 patients in the after-FROGS group, whereas 8 patients underwent bowel resection in the before-FROGS group. There were no significant differences in postoperative complications and mortality within 30 days after hernia presentation between the two groups.Conclusion: Manual reduction using the FROGS technique was found to be safe and reproducible and can be the first treatment choice for patients with obturator hernia.
Effect of Environmental Stressors on the mRNA Expression of Ecdysone Cascade Genes in Chironomus Riparius.
Authors: Fuente Mercedes de la , Folgar Raquel Martín , Martínez-Paz Pedro , Cortés Estrella , Martínez-Guitarte José Luis , Morales Mónica 
Published: May 2021

Abstract
Chemical compounds produced by humans are continuously reaching the environment. In this work, we characterised the expression patterns of important endocrine-related genes involved in the ecdysone pathway in the fourth larval instar of the model species Chironomus riparius after exposure to three chemicals: ethinyl oestradiol (EE), nonylphenol (NP) and bis(tributyltin) oxide (TBTO). We used real-time PCR to analyse the gene expression levels of: ecdysone receptor (EcR) and ultraspiracle (usp), two genes that encode the dimerising partners of the functional ecdysone receptor; the orphan receptor ERR (oestrogen-related receptor), with an unknown function in invertebrates; and E74, an early response gene induced by ecdysteroids. We estimated the bioaccumulation potential, bioavailability and physicochemical properties of these chemicals, together with a number of other exogenous agents known to interfere with the hormonal system. We also provide a review of previous transcriptional studies showing the effect of all these chemicals on ecdysone cascade genes. This analysis provides useful data for future ecotoxicological studies involving invertebrate species.
Very High Sputum Cyanide Concentrations during Acute Pulmonary Exacerbations in Cystic Fibrosis Patients
Authors: Guck Daniel , Kim David , Logue Brian , Bortey-Sam Nesta , Tubbs Nicole , Craft David , Haouzi Philippe 
Published: May 2021

Abstract
Background: Cyanide (CN) has been shown to be chronically present in the airways of cystic fibrosis (CF) patients, as a byproduct Pseudomonas’ metabolism. We sought to determine the concentrations of CN in the sputum of CF patients, who were admitted to the hospital with acute clinical exacerbations using 2 different approaches. Methods: Sputum was collected within 1 day (median) of admission and immediately analyzed for the presence of total and free CN. Results: We found 1) toxic levels of CN in the sputum of our patients, ranging from 27 to 401 µM, 2) the majority of the cyanide was in the form of free, thus diffusible, CN and 3) no cyanide in the blood. Conclusions: While the chronic presence of CN in patients colonized with pseudomonas is not a new concept, the present data support the view that very high levels of free cyanide are present in the airways of CF patients during an acute clinical exacerbation, i.e. levels compatible with concentrations of CN able to virtually stop the mitochondrial activity. It becomes therefore urgent to investigate whether, in CF patients, cyanide is a significant factor affecting the short and long-term outcome and whether a specific treatment of CN intoxication of the airways is warranted during an exacerbation.
Tolerance Mechanisms and Irrigation Management to Reduce Iron Stress in Irrigated Rice
Authors: Carmona Felipe de Campos , Adamski Janete Mariza , Wairich Andriele , de Carvalho Joseane Biso , Lima Gustavo Gomes , Anghinoni Ibanor , Jaeger Isadora Rodrigues , Silva Paulo Regis Ferreira da , Terra Tatiana de Freitas , Fett Janette Palma , Carlos Filipe 
Published: May 2021

Abstract
Iron toxicity is a major nutritional disorder in rice plants, especially in flooded areas. The use of alternative crop management practices, such as soil drainage, may mitigate negative impacts of iron toxicity, since soil aeration that follows drainage can oxidize and precipitate potentially toxic Fe+2 into Fe3+. This study aimed to evaluate the impact of alternative water management on agronomical and physiological parameters in rice plants grown in a field location with iron toxicity history. Rice cultivars BR-IRGA 409 (sensitive) and IRGA 425 (resistant to iron toxicity) were tested. Irrigation management comprised three treatments: Continuous Irrigation (CI), one cycle of water Suppression (1S) and two cycles of water Suppression (2S). Evaluations included the ionic composition of soil solution and leaf tissues, grain yield, antioxidant responses and gene expression. Permanent soil flooding resulted in higher grain yield in plants from the resistant than from the sensitive genotype, which had higher malondialdehyde (MDA) concentrations in leaves. In contrast, two cycles of alternate soil drying resulted in equivalent grain yield and MDA concentrations in both genotypes. Resistance to iron toxicity in IRGA 425 plants seems related to limited Fe translocation to shoots, increased tolerance to oxidative stress in leaves and higher expression of Ferritin, OsGAP1, OsWRKY80 and Oryzain-α genes. Plants from the BR-IRGA 409 cultivar (sensitive to Fe toxicity) improved growth and yield under the interrupted irrigation treatments, probably due to lower Fe availability in the soil solution. Management of water irrigation successfully alleviated Fe toxicity in rice plants cultivated in field conditions.
Coulomb Stress Change in Ahar-Varzaghan (20121108) Earth Quakes
Authors: Sorkhabi Omid Memarian 
Published: May 2021

Abstract
Understanding how the movement of faults and deformation affects such as motion-induced surface stress and strain, which is very important in seismic regions. The best way to learn about the effects of fault movement is modeled. For example, the modeling of surface displacement or deformation and the amount of damage earthquake can be estimated by the model. Coulomb stress changes can be modeled or predicted earthquake aftershocks or future Earthquakes. we employ assumptions on the orientations, rupture lengths and average slip associated with each earthquake to calculate stress changes. Using this model, we displacement, stress and strain at any depth in the Earth's surface acquired. In this study the modeling of earthquakes Mw= 6.5, Mw=6.3 Ahar-Varzaghan. The earthquakes induced displacements, strains and stresses were calculated at the surface at an average depth and its aftershocks for 10-km Ahar and 4 km Varzaghan.
Phenylpropanoid conjugated iridoids with anti-malarial activity from the leaves of Morinda morindoides
Authors: Hashim Yasinjan , Toume Kazufumi , Mizukami Shusaku , Ge Yue-Wei , Taniguchi Mayumi , Teklemichael Awet Alem , Huy Nguyen Tien , Bodi Joseph M. , Hirayama Kenji , Komatsu Katsuko 
Published: May 2021

Abstract
Two phenylpropanoid conjugated iridoids, deglucosyl gaertneroside (1) and morindoidin (2), were isolated from the leaves of Morinda morindoides (Rubiaceae) by activity-guided fractionation using an anti-malarial activity assay. The known related iridoids molucidin (3) and prismatomerin (4), two lignans, abscisic acid, two megastigmanes, and two flavonol glycosides were also identified. The structures of isolated compounds were elucidated using spectroscopic analysis. The isolated compounds were evaluated for anti-malarial activity against the chloroquine/mefloquine-sensitive strains of Plasmodium falciparum together with cytotoxicity against adult mouse brain cells. Potent anti-malarial activity of 3 and 4 (IC50 of 0.96 and 0.80 µM, respectively) was shown, while new iridoids 1 and 2 and pinoresinol (5) displayed moderate activity (IC50 of 40.9, 20.6, and 24.2 µM, respectively). These results indicate that 1–5 may be promising lead compounds for anti-malarial drugs and that extracts of M. morindoides leaves could be effective remedies for malaria infection.
Role of 2′-Hydroxycinnamaldehyde In The Induction of Apoptosis Via A Reactive Oxygen Species-Dependent JNK Pathway in Human Promyelocytic HL-60 Leukemia Cells
Authors: Chung Kyung-Sook , Yoo Chae-Bin , Lee Jeong-Hun , Lee Hwi-Ho , Park Sang-Eun , Han Hee-Soo , Lee Su-Yeon , Jeong Seung Yeon , Kwon Byoung-Mok , Choi Jung-Hye , Lee Kyung-Tae 
Published: May 2021

Abstract
Background: Because the role and molecular mechanism of 2′-hydroxycinnamaldehyde (2′-HCA) in human leukemia need to be clarified, we provide detailed insights into the mechanism underlying the anti-proliferative properties of 2′-HCA in acute myeloid leukemia (AML).Methods: We performed MTT assay to examine the cytotoxic effect of 2′-HCA. 2′-HCA-induced apoptotic pathway was demonstrated by annexin V-FITC/ propidium iodide double staining, DAPI staining for DNA fragmentation detection, and western blot analysis. ROS generation, intracellular glutathione (GSH) level, and intracellular protein thiols (PSH) were detected to investigated the mechanism of 2′-HCA-related apoptosis. Xenograft animal model was used to evaluate anti-tumor activities of 2′-HCA.Results: The present study demonstrated that 2′-HCA induced apoptosis in human promyelocytic leukemia HL-60 cells through the activation of mitochondrial pathways. 2′-HCA also induced the activation of JNK and the pharmacological inhibition of JNK effectively prevented 2′-HCA-induced apoptosis and AP-1-DNA binding. In addition, 2′-HCA resulted in the accumulation of ROS and depletion of intracellular GSH and PSH in HL-60 cells. Xenograft mice inoculated with HL-60 leukemia cells demonstrated that the intraperitoneal administration of 2′-HCA inhibited tumor growth by increasing of TUNEL staining, the expression levels of nitrotyrosine, pro-apoptotic proteins, and PCNA protein expression. Conclusion: Our findings suggest that 2′-HCA induces apoptosis via the ROS-dependent JNK pathway and could be considered as a potential therapeutic agent for leukemia.
Dose Escalation Biodistribution, Positron Emission Tomography/Computed Tomography Imaging and Dosimetry of a Highly Specific Radionuclide-labeled Non-blocking Nanobody
Authors: yanling Yang , Zhao Feng , Chen Daquan , Wang Chao , Sun Yan , Xu Tao , Xu Hui , Fan Huaying 
Published: May 2021

Abstract
Backgroud: Immunotherapy is a valuable option for the treatment of cancers, and the curative effect anti-PD-1/PD-L1 therapy correlates closely with PD-L1 expression levels. Positron emission tomography (PET) imaging of PD-L1 expression is feasible using 68Ga-NOTA-Nb109 nanobodies. 68Ga-NOTA-Nb109 was generated by radionuclide (68Ga) labeling of Nb109 using a NOTA chelator. To facilitate clinical trials, We explored the optimal dose range of 68Ga-NOTA-Nb109 in BALB/c A375-hPD-L1 tumor-burdened nude mice and C57-hPD-L1 transgenic MC38-hPD-L1 tumor-burdened mice by intravenous of a single intravenous dose of 68Ga-NOTA-Nb109 and confirmed the dose in cynomolgus monkeys. The biodistribution data of cynomolgus monkey PET images were extrapolated to estimate the radiation dose for the adult male using OLINDA2.1 software.Results: 68Ga-NOTA-Nb109 was stable in physiologic media and human serum. Ex vivo biodistribution studies showed rapid and specific uptake in A375-hPDL1 or MC38-hPDL1 tumors. The estimated ED50 was approximately 5.4 µg in humanized mice. The injected mass (0.3–100 µg in nude mice and approximately 1–100 µg in humanized mice) greatly influenced the general biodistribution, with a better tumor-to-background ratio acquired at lower doses of Nb109 (0.3–10 µg in nude mice and approximately 1 µg in humanized mice), indicating maximum uptake in tumors at administered mass doses below the estimated ED50. Therefore, a single 15 μg/kg dose was adopted for the PET/CT imaging in cynomolgus monkey. The highest specific and persistent uptake of the tracer was detected in the spleen, with the exception of the levels in the kidney and urine bladder, which was related to metabolism and excretion. The spleen-to-muscle ratio of the tracer exceeded 10 from immediately to 4 h after administration, indicating that the dose was appropriate. The estimated effective dose was calculated to yield a radiation dose of 4.1 mSv to a patient after injection of 185 MBq of 68Ga-NOTA-Nb109.Conclusion: 68Ga-NOTA-Nb109 showed specific accumulation in hPD-L1 xenografts in ex vivo biodistribution studies and monkey PET/CT imaging. The dose escalation distribution data provided a recommended dose range for further use, and the safety of the tracer was confirmed in dosimetry studies.
Ecological Risk Assessment of Heavy Metal in the Bottom Sediment of River Surma, Bangladesh using Monte Carlo Simulation and Multivariate Statistical Analysis.
Authors: Acharjee Arup , Ahmed Zia , Alam Rafiul , Rahman Md. Safiur , Xie Zhixiao 
Published: May 2021

Abstract
The study aims to achieve an accurate assessment of 7 heavy metals, including Cu, Fe, Mn, Zn, Ni, Pb and Cd. Data were collected from 15 sampling stations and analyzed by atomic absorption spectrophotometry. The potential detrimental effects of these heavy metals were evaluated by Hakanson risk index. Hakanson risk index (RI) and Monte Carlo Simulation (MCS) and the ecological risk were articulated as probability distribution of Risk Index values instead of single point values to estimate the uncertainties in the risk evaluation process. The results showed that the levels of SEF (sediment enrichment factor) in the sediments were in the following order: Ni > Pb > Cd > Mn > Cu > Zn. Geo-accumulation index (Igeo) values showed no pollution for most of the metals except Ni, which portrayed the sediment was moderately contaminated and may have adverse effects on the ecology of the river. RI values from Hakanson Risk Index showed each individual station are at low ecological risks throughout the study area. According to the Monte Carlo simulation results and the traditional Hakanson risk index, the cumulative probability of Risk Index (RI) values is less than 150, which, according to the Hakanson risk index, represents low ecological risk. From the sensitivity analysis, the comparatively highest contribution to variance can be ranked as Cd > Pb > Ni > Zn > Cu. The outputs of this study could be used to assess ecological risk near urban area river sediment and help predict how the disposal of domestic sewage will affect the riverine ecosystem.
Precipitation in Iran from 2003 to 2021
Authors: Sorkhabi Omid Memarian 
Published: May 2021

Abstract
Satellite data between 2003 and 2021 have been used for Iran's precipitation. The average monthly precipitation is about 20 mm. The maximum amount of monthly precipitation is observed in 2019. The average is 233 mm. The lowest precipitation years in Iran are 2009, 2019 and 2018, respectively, and the highest precipitation is in 2020, 2007 and 2005, respectively.
A realist evaluation of the continuum of HIV services for men who have sex with men
Authors: Dunbar Willy , Labat Aline , Maulet Nathalie , Coppieters Yves 
Published: May 2021

Abstract
Men who have Sex with Men (MSM) represent the risk group that are disproportionately most affected by human immunodeficiency virus (HIV), yet are understudied in intervention research. This realist evaluation assessed the continuum of HIV services for MSM in Haiti. Guided by the Context-Mechanisms-Outcomes configuration, first, aninitial program theory (IPT) was developed based on reviews, observations and discussions. Second, the IPT was tested using a mixed-method explanatory study. Third, we refined the IPT by eliciting the underlying mechanisms. The results showed that the current service delivery model is suboptimal in engaging and retaining MSM, resulting in loss to follow-up and failure to fully realize the health benefits of antiretroviral. However, the mechanisms through which linkages across the continuum can be improved are: self-acceptance, sense of community support and sense of comprehensive and tailored HIV services. Our evaluation highlighted the importance of taking a comprehensive approach to improve the continuum.
A Novel Methodology Using Dexamethasone To Induce Neuronal Differentiation in The CNS-Derived Catecholaminergic CAD Cells
Authors: Khongkla Ekkaphot , Uppakara Kwanchanok , Boonmuen Nittaya , Bhukhai Kanit , Saengsawang Witchuda 
Published: May 2021

Abstract
The Cath.a-differentiated (CAD) cell line is a central nervous system-derived catecholaminergic cell line originating from tyrosine hydroxylase (TH)-producing neurons located around the locus coeruleus area of the mouse brain. CAD cells have been used as an in vitro model for cellular and molecular studies due to their ability to differentiate under serum-free media conditions. However, the lack of serum-derived survival factors, limits the longevity for differentiated CAD cells to be maintained in healthy conditions; thereby, limiting their use in long-term culture studies. Here, we present a novel differentiation method that utilizes dexamethasone (Dex), a synthetic glucocorticoid receptor agonist. Specifically, we discovered that the addition of 100 µM of Dex into the 1% fetal bovine serum (FBS)-supplemented media effectively induced neuronal differentiation of CAD cells, as characterized by neurite formation and elongation. Dex-differentiated CAD cells exited the cell cycle, stopped proliferating, extended the neurites, and expressed neuronal markers. These effects were dependent on the glucocorticoid receptors (GR) as they were abolished by GR knockdown. Importantly, Dex-differentiated CAD cells showed longer survival duration than serum-free differentiated CAD cells. In addition, RNA-sequencing and qPCR data demonstrate that several genes involved in proliferation, neuronal differentiation, and survival pathways were differentially expressed in the Dex-differentiated cells. This is the first study to reveal Dex as a novel differentiation methodology used to generate postmitotic neuronal CAD cells, which may be utilized as an in vitro neuronal model for cellular and molecular neurobiology research.