bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Efficacy of Cerebrolysin and Cerebrolysin plus Nootropics in the Treatment of Patients with Acute Ischemic Stroke in Vietnam
Authors: Tran Luc , Alvarez X. Anton , Le Hoang-Anh , Nguyen Dat-Anh , Le Thinh , Nguyen Ngoc , Nguyen Thang , Nguyen Tai , Vo Tan , Tran Tuan , Duong Chinh , Nguyen Huyen , Nguyen Sam , Nguyen Hien , Le Thanh , Nguyen Minh , Nguyen Thang 
Published: August 2021

Aims:To investigate the efficacy and safety of Cerebrolysin and Cerebrolysin plus nootropics in the routine treatment of patients with acute ischemic stroke (AIS).Background:Acute ischemic stroke (AIS) is a leading cause of disability with unmet treatment needs lacking effective drug therapy. Multimodal drugs modulating stroke pathophysiology as Cerebrolysin constitute a good therapeutic option.Objective:In this study, we assessed the effects of Cerebrolysin and Cerebrolysin plus nootropics, in comparison with other nootropic drugs alone, on functional, neurological and cognitive recovery of patients with AIS in Vietnam.Methods.:This non-interventional, controlled, open-label, prospective and multicenter study included 398 AIS patients (234 males) treated with Cerebrolysin (n=190; 20 i.v. infusions of 10 ml), other nootropics (comparator group; n=86), or a combination of both (n=122). The study primary endpoint was the modified Ranking Scale (mRS) score on day 90. Secondary endpoints included study-period change in NIHSS score; percentage of well-recovered (mRS 0-2) patients, the proportion of good NIHSS response (≥6 points) cases, and MoCA scores at day 90; and safety indicators.Results:Compared with other nootropics, both Cerebrolysin and combined therapy induced significant improvements (p<0.001) in: Functional recovery (mRS scores); percentage of well-recovered patients (Cerebrolysin: 81.6%; combination: 93.4%; comparator: 43.0%); neurological recovery (study- period NIHSS change); proportion of good NIHSS responders (Cerebrolysin: 77.5%; combination: 92.5%; comparator: 47.6%); and MoCA scores (Cerebrolysin: 23.3±4.8; combination: 23.7±4.1; comparator: 15.9±7.7). Compared to Cerebrolysin, combined therapy improved (p<0.01) mRS outcomes and NIHSS change, but not MoCA scores, in moderate-severe stroke (NIHSS>11) cases only. No drug-related adverse events were reported.Conclusion:Cerebrolysin alone or combined with other nootropics was effective and safe in routine AIS treatment, during both acute and recovery phases, which supports its use in daily clinical practice.Other:According to the results of this multicenter study, the importance of reducing differences in the treatment regimens of AIS in Vietnam should be further emphasized.
The Outcomes of Small-Molecule Kinase Inhibitors and the Role of
ROCK2 as a Molecular Target for the Treatment of Alzheimer's Disease
Authors: Tolomeu Heber Victor , Fraga Carlos Alberto Manssour 
Published: August 2021

Background:
Alzheimer's disease is rapidly becoming a major threat to public health,
with an increasing number of individuals affected as the world's population ages. In this sense, studies
have been carried out aiming at the identification of new small-molecule kinase inhibitors useful
for the treatment of Alzheimer's disease.

Objective:
In the present study, we investigated the compounds developed as inhibitors of different
protein kinases associated with the pathogenesis of Alzheimer's disease.

Methods:
The applied methodology was the use of the Clarivate Analytics Integrity and ClinicalTrials.
com databases. Moreover, we highlight ROCK2 as a promising target despite being little studied
for this purpose. A careful structure-activity relationship analysis of the ROCK2 inhibitors was performed
to identify important structural features and fragments for the interaction with the kinase active
site, aiming to rationally design novel potent and selective inhibitors.

Results:
We were able to notice some structural characteristics that could serve as the basis to better
guide the rational design of new ROCK2 inhibitors as well as some more in-depth characteristics
regarding the topology of the active site of both isoforms of these enzymes, thereby identifying differences
that could lead to planning more selective compounds.

Conclusion:
We hope that this work can be useful to update researchers working in this area, enabling
the emergence of new ideas and a greater direction of efforts for designing new ROCK2 inhibitors
to identify new therapeutic alternatives for Alzheimer's disease.
Implication of Covid-19 on Neurological Complications with Specific Emphasis
on Alzheimer’s and Parkinson’s Disease
Authors: Sood Ankita , Goyal Ravi , Singh Harshdeep , Behl Tapan , Arora Sandeep , Saini Balraj , Kaur Rajwinder 
Published: August 2021

:
It is noticeable how the novel coronavirus has spread from the Wuhan region of China
to the whole world, devastating the lives of people worldwide. All the data related to the precautionary
measures, diagnosis, treatment, and even the epidemiological data are being made freely accessible
and reachable in a very little time as well as being rapidly published to save humankind from
this pandemic. There might be neurological complications of COVID-19 and patients suffering
from neurodegenerative conditions like Alzheimer’s disease and Parkinson’s disease might have
repercussions as a result of the pandemic. In this review article, we have discussed the effect of
SARS-CoV-2 viral infection on the people affected with neurodegenerative disorders such as
Parkinson’s and Alzheimer’s. It primarily emphasizes two issues, i.e., vulnerability to infection and
modifications of course of the disease concerning the clinical neurological manifestations, the advancement
of the disease and novel approaches to support health care professionals in disease management,
the susceptibility to these diseases, and impact on the severity of disease and management.
IMPLEMENTATION OF INTERPROFESSIONAL COLLABORATIVE PRACTICE IN TYPE B TEACHING GENERAL HOSPITALS: A MIXED METHODS STUDY
Authors: Fathya Nurul Aida , Effendy Christantie , Prabandari Yayi Suryo 
Published: August 2021

Background: The concept of patient centered health services encourages interprofessional collaboration practice (IPCP), including teaching hospitals. IPCP in teaching hospitals expected to be implemented properly as a role model for students. Students in academic stage are expected to understand the concept of interprofessional education (IPE) and apply IPCP concept during clinical practice. This study aimed to determine the implementation of IPCP and various factors related to IPCP in teaching hospitals.Methods: This study used a mixed methods-sequential explanatory design with the subjects of healthcare professionals at RSUD R Syamsudin SH recruited using systematic random sampling. The research began with collecting quantitative data to measure the implementation of IPCP using the Indonesian version of the Assessment of Interprofessional Team Collaboration Scale-II (AITCS-II), continued with collecting qualitative data with in-depth interviews to explored IPCP and various factors associated with its implementation.Results: A total of 320 respondents filled out the AITCS-II questionnaire and 11 participants were interviewed deeply. More than 66% of respondents had a good collaboration in each domain; 73,8% of respondents had a good collaboration in IPCP; profession background significantly contributed IPCP (p <0.05). Qualitative analysis was carried out with a semantic theme and obtained 3 themes: not ideal IPCP implementation, perception of IPCP domains by healthcare professionals and barriers in implementing IPCP. Conclusion: The perception of IPCP that well implemented may resulted from improper understanding of IPCP. We still found barrier in implementing IPCP related to stereotypes, hierarchical culture, interprofessional communication and regulation.
IMPLEMENTATION OF MULTI-PROFESSIONAL EDUCATION: A SHORT REVIEW OF THE RESEARCH METHODOLOGY AND BIOSTATISTICS COURSE
Authors: Novrinda Herry 
Published: August 2021

Background: The faculty of Dentistry Universitas Indonesia (FDUI) has implemented multiprofessional education (MPE) since the academic year of 2012/2013. Some concerns about facilitators and the achievement of students arose. This study aims (1) to describe the curriculum mapping, (2) to elaborate the perception of facilitators regarding the implementation of MPE, and (3) to assess the achievement among non-MPE and MPE groups in a particular subject.Methods: This research used a quantitative and qualitative approach. This research collected the data of achievement, perception of facilitators, and the curriculum in order to assess the implementation of MPE.Results: The curriculum consisted of common subjects or topics. There were some suggestions regarding the facilitators and the curriculum in the implementation of MPE. In line with one-way Annova, the mean score of students among Non-MPE (76.52±4.36), MPE_2012 (75.52±4.39), and MPE_2013 groups (75.46±4.66) were not statistically different with p-value = 0.154. Conclusion: The faculty has succeeded in compiling an integrated MPE curriculum. There are opportunities for an improvement in several areas. The academic achievement of MPE students is as good as Non-MPE students. The MPE group’s research proposals seemed to have a spirit of collaboration.
Evolution of Percutaneous Renal Access
Authors: Ahmed Mussammet D , Dhanasekaran Ananda Kumar 
Published: August 2021

Introduction: Nephrostomy insertion is a vital part of modern-day urology used to manage obstructed renal tract or gain percutaneous renal access. Method: We carried out a PubMed literature search on the history of the development of nephrostomies. Results: The first percutaneous nephrostomy was performed in 1864 on a child who died in 5 years. Nephroscopy was then described and performed in 1941 during an open surgery with subsequent advancement to percutaneous nephrolithotomy in 1976 and antegrade stent insertion in 1978. Conclusion: Clinical need and innovation have led to percutaneous renal access and subsequent stone treatment modality.
Does Visibility of an Engagement Partner's Association with Recent Client Restatements Increase Fee Pressures from Non-Restating Clients?
Authors: Chi Wuchun , Lisic Ling Lei , Myers Linda A. , Pevzner Mikhail , Seidel Timothy A. 
Published: August 2021

SYNOPSIS
We examine whether engagement partners who have recently been associated with client restatements experience increased audit fee pressures from their non-restating clients. Using data from the United States (U.S.) and Taiwan, we find evidence of lower audit fees among non-restating companies whose audit engagement partner was recently associated with another client's restatement. These findings are generally strongest when the partner-associated restatement is more prominent or severe, and in the U.S., when non-restating clients are in the same industry as the restating client. Although we find very limited evidence that fee pressures lead to lower-quality audits for these partners' other clients in Taiwan, we find that when the partner-associated restatement is more prominent or severe, fee pressures negatively impact audit quality in the U.S. These findings provide further insight on the impact of engagement partner disclosure for audit quality.
JEL Classifications: M41; M42.
Relevance of Accounting Research (ROAR) Scores: Ratings of Titles and Abstracts by Accounting Professionals
Authors: Burton F. Greg , Summers Scott L. , Wilks T. Jeffrey , Wood David A. 
Published: August 2021

SYNOPSIS
The relevance of academic accounting research to practice has been frequently discussed in the accounting academy, yet very little data has been put forth in these discussions. We create Relevance of Accounting Research (ROAR) scores by asking accounting professionals to read and evaluate the titles and abstracts of every article published in 12 leading accounting journals for the years 2016 to 2018, inclusive. These scores allow for an evidence-based evaluation and discussion of how academic accounting research is perceived by accounting professionals. The scores also allow us to identify the articles, authors, journals, and accounting topic areas that are perceived to be more relevant to accounting practice. By continuing to produce these scores in perpetuity, we expect this data to help academics and professionals better identify and utilize research relevant to the accounting profession.
Combining Data Analytics with XBRL: The ViewDrive Case
Authors: Tadesse Amanuel F. , Vincent Nishani Edirisinghe 
Published: August 2021

ABSTRACT
This advisory case is designed to develop data analytics skills using multiple large real-world datasets based on eXtensible Business Reporting Language (XBRL). This case can also be used to introduce students to XBRL concepts such as extension taxonomies. Students are asked to recommend an XBRL preparation software for a hypothetical company (ViewDrive) that is adopting XBRL to satisfy the financial report filing requirements imposed by the Securities and Exchange Commission (SEC). Students perform data-cleansing (extract, transform, load) procedures to prepare large datasets for data analytics. Students are encouraged to think critically, specify assumptions before performing data analytics (using analytic software such as Tableau), and generate visualizations that support their written recommendations. The case is easy to implement, promotes active learning, and has received favorable student and instructor feedback. This case can be used to introduce technology and data analytics topics into the accounting curriculum to help satisfy AACSB's objectives.
Speech performance in adult patients undergoing Invisalign treatment:
Authors: Fraundorf Erin Corsi , Araújo Eustáquio , Ueno Hiroshi , Schneider Patricia Pigato , Kim Ki Beom 
Published: August 2021

ABSTRACTObjectivesTo assess speech performance of adult patients undergoing orthodontic treatment with Invisalign.Materials and MethodsTwenty-four adult patients with Invisalign (Invisalign group: 6 men, 18 women; average age; 34.88 years) and 20 adult patients with fixed labial appliances (fixed group: 5 men, 15 women; average age; 38.85 years) were evaluated. Speech was recorded immediately before delivery of the first set of clear aligners or bonding of labial appliances (T0), immediately after delivery or bonding (T1), and 2 months after delivery or bonding (T2). Speech was evaluated via a combination of three auditory analyses: (1) objective acoustic analysis through digital sonography, (2) semiobjective assessment by six speech and language pathologists, and (3) subjective assessment patient questionnaire.ResultsThe objective acoustic analysis showed a statistically significant difference over time from T0 to T1, T1 to T2, and T0 to T2 for Invisalign patients. The semiobjective analysis revealed a significant speech alteration from T0 to T1 and T1 to T2 for both groups, and from T0 to T2 in the Invisalign group. The subjective analysis showed a significant difference between means of Invisalign and fixed group patient perception at both T1 and T2.ConclusionsInvisalign treatment significantly affected speech, and although patients experience some level of adaptation, speech does not return to normal after 2 months of treatment.
Administrative-legal means of legal regulation prevention of corruption in Ukraine
Authors: Priymak V.A. 
Published: August 2021

The purpose of the article is to define the concept and features of administrative and legal means of legal regu-lation of corruption prevention.
It is substantiated that the administrative and legal means of preventing corruption is an integral part of legal reg-ulation. The use of these funds is conditioned by the goals of preventing corruption, which are divided into strategic and tactical. The essence of administrative and legal means of preventing corruption is considered in accordance with the regulatory, institutional, instrumental, normative, managerial, activity and state-centered approaches. Ac-cording to the regulatory aspect, administrative and legal means of preventing corruption are understood as a means of streamlining public relations and a way for the subjects of anti-corruption activities to exercise their powers. In the institutional aspect, these means should be understood as a set of bodies and their officials determined by legis-lative and subordinate legal acts, whose powers include the prevention of corruption, as well as the competence of these entities. In the instrumental aspect, administrative and legal means of preventing corruption are technologi-cally legal techniques and methods of implementing administrative and legal regulation in the studied area, as well as algorithms for the application of these techniques and methods. In the normative aspect, the investigated means represent a hierarchically structured set of legislative and subordinate legal acts, including international legal acts that have been ratified, approved or adopted in accordance with the established procedure. In the managerial aspect, administrative and legal means of preventing corruption are a set of managerial actions and decisions of a nation-wide, sectoral and intradepartmental nature aimed at creating organizational, personnel, financial, material and other conditions for the effective prevention of corruption by the subjects of this activity. In the activity aspect, the investigated means represent a set of legal and extra-legal actions of the subjects of preventing corruption, aimed at achieving the goals and objectives set in the anti-corruption program documents in accordance with the established deadlines and stages. The state-centered aspect encompasses a set of ways to preserve the interests of the state, which include preventing corruption in comparison with the interests of a number of officials to preserve their right to privacy of information about their property, income and expenses, to combine some positions and professions, and the like.The set of administrative and legal means, united by specific goals of law enforcement and directed by the will of the subject of legal relations, is an organic part of administrative and legal regulation. However, the phenomenon of administrative-legal regulation is not limited to administrative-legal means, its integral parts are also the purpose, principles, methods, and also other elements that are distinguished by various researchers.
Religion and human rights in artificial insemination.
Authors: Hromovchuk M. , Byelov D. 
Published: August 2021

It is pointed out that modern man is particularly sensitive to the imposition of any worldview and way of life. The only language in today's world is the language of freedom, even if there is a substitution of this concept and its abuse. The value of freedom is not indifferent to religion. Therefore, the only way to spread the religious worldview in society is not the force of coercion, but the force of gravity.
It is noted that the problem of the relationship between bioethics and religion is determined by a number of reasons, both scientific and theoretical, and socio-cultural plan. The current stage of development of scientific thought is characterized by the emergence of a new phenomenon - bioethics. Bioethics is an integrative science that synthesizes knowledge about man, which is already substantiated in medicine, psychology, psychiatry, religious anthropology, philosophical anthropology and others. The moral aspect is the center of bioethics, it is associated with its attitude to all living things, to life as such. Because of this we can talk about the formation of a bioethical worldview as a holistic system of views on the human problem. The beginning of the process of forming a bioethical worldview is closely connected with scientific progress, biomedical practices, and the aggravation of religious problems. The uniqueness of bioethical discourse creates the preconditions for the development of philosophical and methodological ground for the study of bioethical worldview. The methodological significance of the problem is related to the need to rethink the fundamental philosophical problems that relate to demental philosophical problems that relate to the definition of attributive characteristics of man.
It is established that the religious problems that arise when using the IVF method are associated with several components: the production of germ cells, the lack of connection between conception and the natural idea of marital intimacy, obtaining an excessive number of embryos and manipulating them (elimination, reduction, freezing) embryos, preimplantation diagnosis), the use of germ cells of third parties. In this case, in vitro fertilization can be morally justified by religion and an acceptable method of infertility therapy for the Orthodox Christian, if it does not kill embryos and does not break the bond "in the flesh" even at the level of gametes.
A comprehensive evaluation of county economies in the Beijing-Tianjin-Hebei Region based on entropy TOPSIS analysis
Authors: Sen Lu , Yang Zhang , Caihong Zhang , Chengliang Wu 
Published: August 2021

Abstract
Although the economy of a county that is linked to surrounding towns and rural areas constitutes a multiple basic economic unit within China's national economy, it usually exhibits independent characteristics and functions. Consequently, a county's economy plays a critical role in the overall economic development of a country's national economy. We created an evaluation index system based on entropy Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) to carry out a comprehensive evaluation of county economy across the entire Beijing-Tianjin-Hebei region. We found serious imbalances in the development of these counties, with county economies within Beijing and Tianjin being more advanced than those in Hebei Province. Furthermore, there were marked differences between county economies within prefecture-level cities of Hebei Province. The developmental level of counties in cities like Langfang, Tangshan and Chengde was relatively high. Conversely, the level of development of counties in Hengshui, Baoding, Xingtai and Handan was lower. Moreover, there were imbalances among cities in relation to county economic development, especially in Langfang, with smaller differences being found in Hengshui and Qinhuangdao. We analysed and identified the factors influencing differences between counties before providing recommendations.
National Health Reforms in Georgia during 1994-2021 and their Success
Authors: Gigauri Iza , Djakeli Kakhaber 
Published: August 2021

Abstract
The Health Reform of the country is a very difficult burden for two reasons: firstly, we need an appropriate economy level in the country, that can bear the new health model, established through reform, and secondly, the country needs a health system that is appropriate either for its economic system or for its tradition and history. Health reformers need to match all the points of the health reform concept, its implementation, and the systems of the country. Due to its Soviet past, Georgia struggled in the last twenty years to find an effective and cost efficient health model for its citizens. Starting from the 90s, Georgia instituted three health reforms and finally found some sustainable measures. The present article explores the three waves of the Georgian Health Care reforms, and analyses the factors of their success and the reasons for their failures. The importance of studying the Health Care systems is derived from Sustainable Development Goals targeting Health issues including health-related topics to improve the population’s health and wellbeing as well as achieve universal coverage of health services. The research contributes to the knowledge regarding the Health Care Reforms, and their practical implications on a country.