bluuebunny/crossref_metadata_2025_split huggingface dataset:
Standardization of the Pharmaceutical Substance of the Drug LCS-1208
Authors: Ignateva E. V. , Yartseva I. V. , Shprakh Z. S. , Bud'ko A. P. , Ektova L. V. , Kozin D. A. , Reshetnyak V. Yu. , Nesterova O. V. , Pankratova E. A. 
Published: August 2021

Introduction. Indolocarbazole derivatives are of increasing scientific interest for practical oncology. A number of N-glycosides, indolo[2,3-a] carbazole under the laboratory code LCS, were synthesized in the laboratory of chemical synthesis of the National Medical Center of Oncology named after N.N. Blokhin. Currently, one of the most promising compounds in this class is LCS-1208, a representative of the arabinoside class of indolo [2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione. According to the mechanism of biological action, LCS-1208 is a protein kinase C inhibitor and is of great interest for the treatment of malignant neoplasms.Aim. chemical and pharmaceutical standardization of the pharmaceutical substance LCS-1208.Materials and methods. Laboratory samples of pharmaceutical substance LCS-1208. Methods of investigation: gravimetry, spectrophotometry, polarimetry, high-performance liquid chromatography (HPLC), high-resolution nuclear magnetic resonance (NMR) spectroscopy and infrared (IR) spectroscopy.Results and discussion. The quality assessment of LCS-1208 was carried out according to the indicators adopted in the XIV edition of the State Pharmacopoeia of the Russian Federation for quality control of pharmaceutical substances. LCS-1208 - orange amorphous powder, odorless; soluble in dimethylsulfoxide (DMSO) and dimethylformamide (DMF); very slightly soluble in 95 % ethyl alcohol and practically insoluble in water. The authenticity of the substance is confirmed by NMR and IR spectra, as well as electronic absorption spectra. The values of the specific optical rotation of LCS-1208 (1 % solution in DMF) are placed in the range from +58° to +61°. All the studied samples of the substance were free of inorganic impurities, sulphate ash, heavy metals and contained no more than 1.0 % water, determined by the K. Fischer titration method. The content of possible related impurities in the substance LCS-1208 and the content of the main active substance were determined by HPLC. The studied laboratory series of the pharmaceutical substance LCS-1208 contained no more than 1.0 % of any single and no more than 3 % of the total unidentified impurities. The content of the main active substance was more than 97 %.Conclusion. As a result of the work carried out, quality criteria and parameters were selected and methods for their determination were developed, which allow to adequately assess the quality and standardness of the pharmaceutical substance LCS-1208.
Phytochemical Analysis of <i>Elaeagnus argentea</i> Leaves
Authors: Salnikova N. A. , Shur Yu. V. , Tsibizova A. A. 
Published: August 2021

Introduction. Currently, close attention in the field of pharmacy and medicine is directed to the search for new sources of biologically active substances of various origins, including vegetable. The woody plant Elaeagnus argentea is considered as a promising source. Despite its widespread use in the food industry, folk medicine as an anti-inflammatory, restorative, antimicrobial agent, the chemical composition of this plant has not been sufficiently studied.Aim. Qualitative and quantitative determination of the main groups of biologically active substances (BAS) in the raw material (leaves) of Elaeagnus argentea growing on the territory of the Astrakhan region for further development of a methodology for standardizing the raw material of this plant.Materials and methods. The leaves of Elaeagnus argentea were harvested in the spring in the eastern part of the delta of the Astrakhan region (Volga region). Drying of raw materials was carried out in natural conditions. In the study, unified methods were used: to determine the amount of flavonoids and saponins, the spectrophotometric method was used, ascorbic acid - the titrimetric method. For the analysis of flavonoids in the leaves of Elaeagnus argentea, an aqueous-alcoholic solution of 70 % concentration was used as an extractant. The quantitative content of flavonoids was determined in the obtained raw material extract in terms of luteolin-7-glucoside. The amount of saponins in the leaves of Elaeagnus argentea was determined in terms of oleanolic acid. 96 % ethanol was used as an extractant. The quantitative determination of ascorbic acid in the aqueous extract of crushed raw materials was carried out by titrimetry based on the ability to reduce 2,6-dichlorophenolindophenol.Results and discussion. In the pharmacognostic study of biologically active substances in the leaves of Elaeagnus argentea, the content of ascorbic acid was found to be at least 0.32 %, the amount of flavonoids in terms of luteolin-7-glucoside was at least 1.92 %; saponins - 2.38 %; which indicates the need for a more detailed study of the phytochemical composition of other morphological groups of the plant Elaeagnus argentea growing in the Astrakhan region.Conclusion. The data obtained during the study can be used to confirm the quality of raw materials (leaves) of Elaeagnus argentea. A more detailed study of leaves for the presence of other groups of biologically active substances will make it possible to use the obtained data for the development of regulatory documents for medicinal plant raw materials «Elaeagnus argentea leaves».
Pendidikan Kesehatan Meningkatkan Pengetahuan Perilaku Kekerasan Pada Remaja
Authors: Yolanda Mona , Ahmalia Renty 
Published: August 2021

Perilaku kekerasan merupakan salah satu gangguan jiwa. Satu dari empat orang di dunia mengalami masalah mental. Diperkirakanada sekitar 450 juta orang di dunia mengalami gangguan kesehatan jiwa. Setiap 7 menit di suatu daerah di dunia, seorang remaja terbunuh akibat tindak kekerasan. Remaja kisaran umur 15-19 tahun memiliki peluang tiga kali lebih tinggi untuk meninggal daripada remaja usia 10-14 tahun. Tujuan penelitian ini adalah untuk melihat pengaruh pendidikan kesehatan tentang perilaku kekerasan terhadap pengetahuan remaja di SMKN 1 Pariaman. Penelitian ini menggunakan desain Pre-Eksperimental Desian dengan metode pendekatan One Group Pretest Postest dengan jumlah populasi sebanyak 94 orang remaja sehingga didapatkan sebanyak 48 orang sebagai sampel. Teknik pengambilan sampel yang digunakan dalam penelitian ini adalahpurposive random sampling dengan menggunakan uji chi square. Pengetahuan sebelum diberikan pendidikan kesehatan tentang perilaku kekerasan 48,54 dengan standar deviasi 15,08. Setalah diberikan pendidikan kesehatan tentang perilaku kekerasan 71,15 dengan standar deviasi 15,98. pengetahun remaja sebelum dan sesudah diberikan pendidikan kesehatan tentang perilaku kekerasan yaitu terjadi peningkatan 22,61. Dari hasil uji statistik dengan uji pairet t-tes diperoleh nilai signifikan 0,000. Disimpulkan bahwa setelah dilakukan pendidikan kesehatan tentang perilaku kekerasan pada remaja terdapat pengaruh yang signifikan terjadi dengan pengetahuan remaja tentang perilaku kekerasan pada remaja. Diharapakan bisa di aplikasikan pada siswa dalam kehidupan sehari-hari agar tidak terlibat dalam perilaku kekerasan.
Komunikasi Keluarga Dan Pola Asuh Dengan Kecerdasan Emosional Anak Usia 5 – 18 Tahun
Authors: Sulung Neila , Sakti Genta 
Published: August 2021

Kecerdasan emosional anak-anak sangat penting untuk perkembangan pribadi anak-anak secara menyeluruh. Perkembangan kecerdasan emosional. Adapun tujuan penelitian ini adalah: melihat dampak komunikasi dalam keluarga dan pola asuh orangtua terhadap kecerdasan emosional anak usia 5-18 Tahun. Metodologi penelitian dengan melakukan literature review dari beberapa artikel baik internasional maupun nasional yang dicari dengan mempergunakan google scholar dan sciencedirect, mengisihkan 72 artikel dengan kata kunci Pola asuh, komunikasi dalam keluarga dan kecedasan emosional. yang terdiri dari 36 internasional dan 36 jurnal nasional setelah dilakukan seleksi sesuai kata kunci yang dianalisis 18 artikel, yang terdiri dari 8 artikel internasional dan 10 artikel Nasional penelusuran dengan mempergunakan google scholar dan sciencedirect dengan desain penelitian kuantitatif dan kualitatif. Hasil penelitian: Bahwa pola asuh dan komunikasi keluarga sangat berpengaruh terhadap kecerdasan emosional anak. Kesimpulan: pola asuh demoktratis akan membentuk kecedasan yang positif dan pola komunikasi dengan keluarga yang sangat membantu kecerdasan emosional lebih menekan pada pada durasi waktu interaksi anak dan orang tua. Disarankan pada orang tua untuk memperhatikan pola asuh dan komunikasi keluraga untuk mendapat anak yang cerdas secara emosional
‘All at Sea’: Virginia Woolf, Walter Benjamin, and the Unknown German
Authors: Schad John 
Published: August 2021

On July 10, 1940, amidst fear of Nazi invasion, a prison ship, of sorts, left Liverpool, England, crammed full of over two thousand male ‘Enemy Aliens’ – Germans, Austrians, and some Italians. They were herded together, below deck, with all hatches sealed. Some were prisoners of war, some were passionate Nazis, but most were Jewish refugees. Among them was Walter Benjamin's estranged son, a young man of 22 years, Stefan Rafael Schoenflies Benjamin. Soon after boarding, however, the authorities mistakenly recorded his surname as Benjamini. ‘All at Sea’, John Schad's critical-creative piece, recounts events around ‘the unknown German’ on the vessel, playing richly on, and with, recognition effects around what is (un)familiarly known about Virginia Woolf, Walter Benjamin, and various kinds of connection between them and other figures from the period.
Construction and Validation of a Brief Pandemic Fatigue Scale in the Context of the Coronavirus-19 Public Health Crisis
Authors: Cuadrado Esther , Maldonado Miguel A. , Tabernero Carmen , Arenas Alicia , Castillo-Mayén Rosario , Luque Bárbara 
Published: August 2021

Objectives:The chronic restrictions to mitigate the new SARS-CoV-2 virus may result in pandemic fatigue. This study set out to develop a short, reliable, valid, and gender-invariant instrument—the Pandemic Fatigue Scale (PFS).Methods:In the first phase, 300 students responded to a pilot questionnaire that allowed the reduction and refinement of the items. In the second phase, the validity, reliability, and invariance of the scale were explored among a sample of 596 participants.Results:Factor exploratory and confirmatory analyses confirmed a robust adjustment for the bifactorial structure that explained 79,36% of the variance. The two factors identified were 1) people’s demotivation in continuing to follow the recommended protective behaviors (neglect) and 2) people’s boredom regarding the pandemic-related information (boredom). The pattern of relations between the Pandemic Fatigue Scale and other variables—find through correlation, mediation, and path analyses—and the gender differences—find in the ANOVA analyses—provided strong evidence of the construct validity. Moreover, the PFS was shown to be invariant regarding gender in a multigroup factor confirmatory analysis.Conclusion:The instrument can be of utility for professionals and researchers to assess pandemic fatigue, a variable that can affect the adoption of protective measure to avoid catching and spreading the virus.
Is There a Quadruple Fe-C Bond in FeC(CO)3?
Authors: Nottoli Tommaso , Lipparini Filippo 
Published: August 2021

A recent computational paper (Kalita et al., Phys. Chem. Chem. Phys. 2020, 22, 24178–24180) reports the existence of a quadruple bond between a carbon and an iron atom in the FeC(CO)3 molecule. In this communication, we perform several computations on the same system, using both density functional theory and post-Hartree–Fock methods and find that the results, and in particular the Fe-C bond length and stretching frequency depend strongly on the method used. We ascribe this behavior to a strong multireference character of the FeC(CO)3 ground state, which explains the non-conclusive results obtained with single-reference methods. We therefore conclude that, while the existence of a Fe-C quadruple bond is not disproved, further investigation is required before a conclusion can be drawn.
Streptomyces Application Triggers Reassembly and Optimization of the Rhizosphere Microbiome of Cucumber
Authors: Zhang Yanjiang , Zhang Tian , Xue Zhijing , Liu Yifan , Li Yongzhe , Li Yulong , Chen Qin 
Published: August 2021

Streptomyces partum Act12 and Streptomyces roche D74 are biocontrol strains that can promote plant growth and enhance stress resistance in different crops. However, their effects on the rhizosphere microbiome and the role of the reassembled microbiome in plant growth promotion and stress resistance enhancement remain unclear. This study investigated the variation in the rhizosphere microbiome induced by Streptomyces application through a cucumber (Cucumis sativus L. cv. “Youliang”) pot experiment. The bacterial and fungal communities of rhizosphere soils inoculated with and without Streptomyces were, respectively, compared based on 16S rRNA and internal transcribed spacer rRNA gene sequences. Following Streptomyces application, the bacterial alpha diversity increased significantly, while the fungal alpha diversity exhibited the opposite trend. The bacterial and fungal communities’ compositions clearly shifted in the inoculated soil. Compared with the uninoculated control, the relative abundance of the genus Streptomyces increased by 68.3%, and the bacterial co-occurrence network in the rhizosphere soil was enriched significantly. The relative abundance of bacteria associated with nitrogen fixation was increased by 7.5% following Streptomyces application. Based on the results of this study, we conclude that the application of Streptomyces Act12 and D74 can be used to reassemble and optimize the rhizosphere microbiome of cucumber, which is conducive to plant survival.
THE EFFECT OF ORGANIZATIONAL CULTURE, LEADERSHIP STYLE, KNOWLEDGE MANAGEMENT, WORK DISCIPLINE, AND WORK ENVIRONMENT ON EMPLOYEE SATISFACTION PBEC EYE HOSPITAL
Authors: Taufiq Agus , Isyandi Isyandi , Maulida Yusni 
Published: August 2021

This study aims to analyze the influence of organizational culture, leadership style, knowledge management, work discipline, and work environment on job satisfaction of employees of Pekanbaru Eye Center Eye Center. The data of this study consisted of primary and secondary data, which were taken through a questionnaire to 81 employees of the Pekanbaru Eye Center Eye Center with a sample census. The variables used are organizational culture, leadership style, knowledge management, work discipline and work environment as independent variables and job satisfaction as the dependent variable. The data obtained were processed using SmartPLS.
The results of this study indicate that organizational culture, leadership style and work environment have a positive and significant effect on employee job satisfaction. Knowledge management has a negative effect on employee job satisfaction, and work discipline does not have a significant effect on employee job satisfaction.
EFFECT OF MARKETING MIX ON TOURIST SATISFACTION AND LOYALTY IN TOURIST AREA OF BONO TELUK MERANTI PELALAWAN REGENCY
Authors: Febrina Lismawati Kerta , Kartikowati Sri , Jahrizal Jahrizal 
Published: August 2021

The study was conducted in the Bono Bay Area of ​​Meranti Bay, Pelalawan Regency. The aim is to find out the direct effect of the Marketing Mix on Tourist Satisfaction and Loyalty. This study took a sample of 145 people. The variables used are the dimensions of Marketing Mix, Tourist Satisfaction and Loyalty. Data were analyzed using SEM (Structural Equation Modeling) analysis which is operated through the SmartPLS 3.2.8 program
The results showed that partially there was an effect of Product, Price, Place, Promotion, People, Process, Psychical evidence on Tourist Satisfaction. and there is the influence of tourist satisfaction on tourist loyalty. The higher the satisfaction that is owned by consumers, the loyalty of tourists is increasing.
Goffman e a interação social nonsense em trechos de através do Espelho e o que Alice encontrou lá, de Lewis Carroll
Authors: Assad Alvares Claudia 
Published: August 2021

Este artigo tem por objetivo verificar a produtividade dos conceitos de footing e fabricações (Goffman, 1974; 1981) na literatura nonsense. Para realizar esse objetivo, linguisticamente, foram escolhidos dois diálogos extraídos dos livros de Alice, de L. Carroll (1980). Delineado o objetivo, os seguintes procedimentos foram adotados: exposição de alguns tópicos da teoria de Goffman (1974; 1981), enriquecida com as contribuições de teóricos como Bateson (1972), Tannen e Wallat (1987) e Quental (1991; 1994), entre outros, bem como uma análise linguística dos diálogos. Nesse contexto, as molduras, associadas aos limites que nos ancoram no real, se rompem e dão lugar ao sonho de Alice: um mundo sem enquadres, marcado por paradoxos e incertezas.
Goffman e a ritualização do infinitamente pequeno: observando o sutil na sustentação do discurso hegemônico em interações de um curso de marcenaria para mulheres
Authors: Venosa Barbara , Cabral Bastos Liliana 
Published: August 2021

O presente trabalho almeja evidenciar as manifestações sutis do discurso dominante em um curso de marcenaria para mulheres, no qual um professor interage com dez alunas mulheres. Com base em reflexões de Goffman sobre situação social, relato de histórias e interação e gênero (Goffman, 2002, 1974/2012, 1976), examinaremos as relações entre participantes do curso quando do relato do professor sobre sua experiência de vida em um ano em uma aldeia indígena.
Tal análise parte de uma perspectiva da Linguística Aplicada Crítica (Moita Lopes, 2016), em articulação com a análise de narrativas (Bastos e Biar, 2015; Biar, 2017; Linde, 1993) e com considerações etnográficas (Garcez e Loder, 2014; Coelho, 2016,). Observaremos a construção do senso de alteridade e de autoridade etnográfica do professor, considerando a sua performance entrelaçada a relações de poder e gênero.
Amyotrophie spinale: une mise à jour
Authors: Perdikari Aliki , Klein Andrea , Jacquier David 
Published: August 2021

proximale liée au chromosome 5q ») est une maladie neuromusculaire progressive touchant les motoneurones inférieurs et causant une faiblesse musculaire croissante. Longtemps considérée comme une des principales causes génétiques de mortalité infantile, les avancées scientifiques des 2 dernières décennies ont permis le développement des premiers traitements spécifiques, marquant une révolution dans la prise en charge. Nous allons ainsi passer en revue la maladie, son mécanisme pathogénique, ses présentations cliniques, et les options thérapeutiques actuellement disponibles.
Tingkat Pengetahuan Ibu Balita Tentang Stunting
Authors: Muzayyaroh Muzayyaroh 
Published: August 2021

Stunting is a condition of a child's body that looks stunted or short if it is based on the body length index according to age. The incidence of stunting is very much found in toddlers aged 12-36 months. Indonesia is a country that has the third highest number of stunting cases in Southeast Asia. The number of stunting cases is nothing but the result of the level of knowledge of parents who do not understand stunting. Parents, especially mothers, have a very important role in the process of child growth and development, especially in meeting the nutritional needs of children so that children can grow well and avoid malnutrition and stunting. The purpose of this research was to find out about the level of knowledge of parents who have toddlers about editing. The method used in this research was descriptive method with data collection through filling out a questionnaire. The population in this study were all mothers of toddlers who attended PAUD Irsyadus Salam with a total of 35 mothers. Sampling by non-probability sampling with purposive sampling type. The result of this research is that most mothers of toddlers have a low level of knowledge about stunting. With the counseling about stunting, it is hoped that all mothers who have children under five can prevent stunting and achieve optimal health and development of toddlers.

Keywords: Stunting, Mother’s Knowledge
ABSTRAK

Stunting merupakan kondisi tubuh seorang anak yang terlihat kerdil atau pendek apabila didasarkan pada indek panjang badan menurut umur. Kejadian stunting sangat banyak di temukan pada balita usia 12-36 bulan. Indonesia merupakan negara yang mempunyai kasus stunting ketiga terbanyak seAsia Tenggara. Banyaknya kasus stunting tidak lain akibat dari tingkat pengetahuan orang tua yang kurang memahami tentang stunting. Orang tua khususnya ibu mempunyai peranan yang sangat penting dalam proses tumbuh kembang anak, terutama dalam pemenuhan kebutuhan gizi anak sehingga anak bisa tumbuh dengan baik dan terhindar dari gizi buruk serta stunting. Tujuan dari penenlitian ini adalah untuk mengetahui tentang tingkat pengetahuan dari orang tua yang mempunyai balita tentang sunting. Metode yang digunakan dalam penelitian ini adalah metode deskriptif dengan pengambilan data melalui pengisian kuesioner. Populasi pada penelitian ini adalah semua ibu balita yang sekolah di PAUD Irsyadus Salam sejumlah 35 ibu. Pengambilan sampel dengan jalan non propability sampling dengan tipe purposive sampling. Hasil dari penelitian ini bahwa paling banyak ibu balita yang mempunyai tingkat pengetahuan yang kurang tentang stunting. Dengan adanya penyuluhan tentang stunting diharapakan semua ibu yang mempunyai anak usia balita bisa mencegah terjadinya stunting dan tercapainya kesehatan tumbuh kembang balita secara optimal.

Kata kunci : Stunting, Pengetahuan Ibu