bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative zoledronic acid for osteoporosis in primary hyperparathyroidism: a randomized placebo-controlled study
Authors: Ryhänen E M , Koski A M , Löyttyniemi E , Välimäki M J , Kiviniemi U , Schalin-Jäntti C 
Published: July 2021

Objective
In primary hyperparathyroidism (PHPT) with osteoporosis, bone mineral density (BMD) improves after parathyroidectomy. It is unclear whether combining surgery with postoperative bisphosphonate treatment can further improve bone health.

Design
This randomized, placebo-controlled study compared the effects of surgery alone and surgery combined with zoledronic acid on bone metabolism in PHPT with osteoporosis.

Methods
Fifty-six patients (f/m 47/9, mean age 68.4 years) with PHPT and osteoporosis were randomized 1–3 months after parathyroidectomy to receive a 2-year treatment of zoledronic acid or placebo. Dual-energy X-ray absorptiometry (DXA) and bone turnover markers (N-terminal propeptide of type 1 procollagen, C-terminal telopeptide of type 1 collagen, and alkaline phosphatase) were measured annually during the 2-year follow-up.

Results
Two years after parathyroidectomy, BMD was significantly higher in the zoledronic acid (ZOL) group compared with the placebo (PBO) group at the femoral neck (P = 0.045 for Z-score) and lumbar spine (P = 0.039 and 0.017 for T- and Z-scores, respectively). Bone turnover markers were significantly lower in the ZOL group (P < 0.001 for all markers). Of the 18 patients who had received bisphosphonates for >1 year before surgery, BMD improved significantly in the ZOL group both in the femoral neck and lumbar spine (n = 10; all P < 0.001–0.01), but in the PBO group, only in the lumbar spine (n = 8, P = 0.03), (P = 0.08–0.95 for between-group changes).

Conclusion
BMD increases after parathyroidectomy both with and without zoledronic acid but the increase is significantly higher with postoperative zoledronic acid.
Twelve-Month Outcomes of the First 1000 Days Program on Infant Weight Status
Authors: Taveras Elsie M. , Perkins Meghan E. , Boudreau Alexy Arauz , Blake-Lamb Tiffany , Matathia Sarah , Kotelchuck Milton , Luo Mandy , Price Sarah N. , Roche Brianna , Cheng Erika R. 
Published: July 2021

OBJECTIVES
To examine the effects of the First 1000 Days intervention on the prevalence of infant overweight and maternal postpartum weight retention and care.

METHODS
Using a quasi-experimental design, we evaluated the effects of the First 1000 Days program among 995 term, low-income infants and their mothers receiving care in 2 intervention community health centers and 650 dyads in 2 comparison health centers. The program includes staff training, growth tracking, health and behavioral screening, patient navigation, text messaging, educational materials, and health coaching. Comparison centers implemented usual care. Infant outcomes were assessed at 6 and 12 months, including weight-for-length z score and overweight (weight for length ≥97.7th percentile). We also examined maternal weight retention and receipt of care 6 weeks’ post partum.

RESULTS
The mean birth weight was 3.34 kg (SD 0.45); 57% of infants were Hispanic; 66% were publicly insured. At 6 months, infants had lower weight-for-length z scores (β: −.27; 95% confidence interval [CI]: −.39 to −.15) and lower odds of overweight (adjusted odds ratio [OR]: 0.46; 95% CI: 0.28 to 0.76) than infants in comparison sites; differences persisted at 12 months (z score β: −.18; 95% CI: −.30 to −.07; adjusted OR for overweight: 0.60; 95% CI: 0.39 to 0.92). Mothers in the intervention sites had modestly lower, but nonsignificant, weight retention at 6 weeks’ post partum (β: −.51 kg; 95% CI: −1.15 to .13) and had higher odds (adjusted OR: 1.50; 95% CI: 1.16 to 1.94) of completing their postpartum visit compared with mothers in the comparison sites.

CONCLUSIONS
An early-life systems-change intervention combined with coaching was associated with improved infant weight status and maternal postpartum care.
Importance of access to epilepsy monitoring units during the COVID‐19 pandemic: consensus statement of the International League Against Epilepsy and the International Federation of Clinical Neurophysiology∗
Authors: Beniczky Sándor , Husain Aatif , Ikeda Akio , Alabri Haifa , Cross J. Helen , Wilmshurst Jo , Seeck Margitta , Focke Niels , Braga Patricia , Wiebe Samuel , Schuele Stephan , Trinka Eugen 
Published: July 2021

AbstractRestructuring of healthcare services during the COVID‐19 pandemic has led to lockdown of epilepsy monitoring units (EMUs) in many hospitals. The ad‐hoc taskforce of the International League Against Epilepsy (ILAE) and the International Federation of Clinical Neurophysiology (IFCN) highlights the detrimental effect of postponing video‐EEG monitoring of patients with epilepsy and other paroxysmal events. The taskforce calls for action for continued functioning of EMUs during emergency situations, such as the COVID‐19 pandemic. Long‐term video‐EEG monitoring is an essential diagnostic service. Access to video‐EEG monitoring of the patients in the EMUs must be given high priority. Patients should be screened for COVID‐19, before admission, according to the local regulations. Local policies for COVID‐19 infection control should be adhered to during the video‐EEG monitoring. In cases of differential diagnosis in which reduction of antiseizure medication is not required, home video‐EEG monitoring should be considered as an alternative in selected patients.
Management of a first unprovoked epileptic seizure in adolescence and adulthood
Authors: Catarina Franco Ana , Parreira Sara , Bentes Carla , Pimentel José 
Published: July 2021

AbstractAn epileptic seizure is one of the causes of so‐called “transient neurological events” (TNEs). The differential diagnosis of a TNE relies mainly on history and physical examination. Laboratory markers are less frequently useful. After diagnosing an epileptic seizure, a distinction must be made between an acute symptomatic and an unprovoked seizure, since they have different treatments and prognosis. History, physical examination and other examinations (laboratory and imaging) are paramount in this distinction. After the diagnosis of a first unprovoked seizure, an EEG should be requested which may aid in establishing the diagnosis, evaluating the recurrence risk or ascertaining the self‐limited nature of the seizure. 3T‐MRI with an epilepsy protocol can be considered when CT has not clarified the aetiology. The decision to treat should be discussed with the patient/relatives, taking into account the risk of recurrence, the clinical characteristics (aetiology, seizure type, age, job, epileptic seizure schedule, comorbidities and polymedication), probability of AED side effects, and stigmatization. Nowadays, the chosen regimen is usually monotherapy with a second‐generation AED that better suits the patient's characteristics, comorbidities and concurrent medication. Counselling should include first aid, precipitating factors, sport and physical exercise in order to avoid possible driving restrictions, the need for therapy compliance, and risk of recurrence and SUDEP.
In the pursuit of the epileptogenic zone – listen carefully and look deeply
Authors: Nascimento Fábio A. , Srinivasan Visish M. , Sheth Sameer A. , Gavvala Jay R. 
Published: July 2021

AbstractWe report a 30‐year‐old right‐handed man with a history of drug‐resistant, non‐lesional, childhood‐onset focal epilepsy featuring (i) focal unaware seizures with left upper extremity automatisms and tonic posturing preceded by an aura of a ringing/beeping noise, and (ii) nocturnal hyperkinetic seizures. Non‐invasive video‐EEG, MEG, and PET were unable to delineate the epileptogenic zone (EZ) warranting an invasive investigation with bilateral depth electrodes (SEEG). SEEG data localized the EZ to the right superior temporal sulcus (STS) and right superior temporal gyrus (STG), wherein the auditory cortex lies, with subsequent ictal spread to anterior topography including the operculo‐insular region. This hypothesis explained the patient's semiology consisting of focal aware seizures featuring auditory phenomena and nocturnal hyperkinetic seizures. Our multi‐disciplinary team elected to proceed with a resection of the posterior right STG guided by electrocorticography (ECoG). Prior to resection, ECoG identified seizures arising from the peri‐sylvian region, seemingly discordant to previous SEEG data. Following resection of the posterior right STG, ECoG continued to show seizures from contacts overlying the parietal operculum. It was not until the cortex was resected, at the depth of the right STS, that ECoG no longer showed epileptiform abnormalities. Pathology revealed focal cortical dysplasia type 1A.
Early vagus nerve stimulator implantation as a main predictor of positive outcome in pediatric patients with epileptic encephalopathy
Authors: Russo Angelo , Hyslop Ann , Gentile Valentina , Boni Antonella , Miller Ian , Chiarello Daniela , Pellino Giuditta , Zenesini Corrado , Martinoni Matteo , Lima Mario , Ragheb John , Cordelli Duccio Maria , Pini Antonella , Jayakar Prasanna , Duchowny Michael 
Published: July 2021

AbstractObjective: We describe a multicenter experience with VNS implantation in pediatric patients with epileptic encephalopathy. Our goal was to assess VNS efficacy and identify potential predictors of favorable outcome.Methods: This was a retrospective study. Inclusion criteria were: ≤18 years at the time of VNS implantation and at least one year of follow‐up. All patients were non‐candidates for excisional procedures. Favorable clinical outcome and effective VNS therapy were defined as seizure reduction >50%. Outcome data were reviewed at one, two, three and five years after VNS implantation. Fisher's exact test, Kaplan‐Meier and multiple logistic regression analysis were employed.Results: Twenty‐seven patients met inclusion criteria. Responder rate (seizure frequency reduction ≥ 50%) at one‐year follow‐up was 25.9%, and 15.3% at last follow‐up visit. The only variable significantly predicting favorable outcome was time to VNS implantation, with the best outcome achieved when VNS implantation was performed within five years of seizure onset (overall response rate of 83.3% at one year of follow‐up and 100% at five years). In total, 63% of patients evidenced improved QOL at last follow‐up visit. Only one patient exited the study due to an adverse event at two years from implantation.Significance: Early VNS implantation within five years of seizure onset was the only predictor of favorable clinical outcome in pediatric patients with epileptic encephalopathy. Improved QOL and a very low incidence of adverse events were observed.
Evaluation of candidate genes in a Chinese cohort of atypical Rolandic epilepsy
Authors: Hu Xiaoyue , Tang Jihong , Hua Ying , Wang Yanping , Huang Jing 
Published: July 2021

AbstractObjective. We aimed to identify new candidate pathogenic genes for atypical Rolandic epilepsy.Methods. We retrospectively evaluated the data from 24 Chinese patients with atypical Rolandic epilepsy who underwent whole‐exome sequencing. Data were analysed regarding the frequency of affected genes, previously reported disease‐related genes, and evaluation based on Kyoto Encyclopaedia of Genes and Genomes (KEGG).Results. We identified a frameshift mutation in the reported gene PRRT2, which is classified as pathogenic according to American College of Medical Genetics and Genomics guidelines (ACMG). We also identified a novel missense mutation in the PRRT2 gene in a family with three affected patients. Several other candidate genes were found in at least two patients, some of which were associated with other epilepsies (ADGRV1, CACNA1A, CHD2, CLCN2, HECW2, KIF1A, NPRL3, RELN and TSC2), while others were mainly associated with neuropsychiatric disease (SHANK3 and AUTS2). The KEGG analysis of 81 candidate genes associated with atypical Rolandic epilepsy identified a significant association with the GABAergic synapse. Candidate genes involved in the GABAergic synapse pathway included NSF, CACNA1A, as well as others.Significance. Our study indicates that PRRT2 mutations may be associated with atypical Rolandic epilepsy. Moreover, we identified a number of unreported candidate genes, including ADGRV1, CHD2, CACNA1A, NSF, NPRL3, KIF1A, GJB2 and HECW2, also associated with atypical Rolandic epilepsy.
Multimodal approach in the pre‐surgical evaluation of focal epilepsy surgery candidates: how far are we from a non‐invasive ESI‐based “sourcectomy”?
Authors: Nobile Giulia , Consales Alessandro , Tortora Domenico , Pacetti Mattia , Gianno Francesca , Arnaldi Dario , Morbelli Silvia , Mancardi Margherita , Sartori Ivana , Cossu Massimo , Nobili Lino , Cataldi Matteo 
Published: July 2021

AbstractThe management of drug‐resistant patients with focal epilepsy is often challenging. Surgery is recognised as a useful and effective treatment option. The identification of the epileptogenic zone relies on the integration of clinical, neurophysiological, and neuroimaging findings. The role of non‐invasive functional neuroimaging techniques has been reported to add diagnostic accuracy to first‐line evaluations, avoiding invasive presurgical examinations in selected cases. In this view, we report the case of a 16‐year‐old male suffering from drug‐resistant focal epilepsy with episodes rarely evolving to a bilateral tonic‐clonic seizure. Conventional 1.5T and 3T MRI were considered uninformative. Based on electro‐clinical data, focal cortical dysplasia was suspected. The epileptogenic zone was identified with the integration of further non‐invasive functional neuroimaging techniques ([18F]‐fluorodeoxyglucose positron emission tomography and arterial spin labelling), where electrical source imaging played the main role. All techniques pointed towards a cortical region, where a 7T brain MRI identified a signal alteration consistent with focal cortical dysplasia. A tailored resection of the lesion located in the inferior frontal sulcus was performed, guided by intraoperative electrocorticography (strip and depth electrodes). Postoperative seizure freedom was achieved. The histopathology confirmed the suspicion of focal cortical dysplasia type IIa. With this case report, we highlight the importance of a multimodal approach in the presurgical evaluation of candidates for epilepsy surgery, which, in selected cases, may allow invasive procedures, such as stereo‐EEG, to be avoided in the investigation of the epileptogenic zone. Moreover, we underline the pivotal role of EEG source imaging, especially when focal cortical dysplasia is suspected.
BRAND RECOGNITION OF FISH SAUCE ORIGIN OF HAI PHONG THROUGH THE CASE STUDY OF THE RETAIL MARKET IN HANOI CITY
Authors: Huu Tung Phuong 
Published: July 2021

Dear Editors!The author is very happy to know the information of the Journal and wishes to submit the article with the topic: "
BRAND RECOGNITION OF FISH SAUCE ORIGIN OF HAI PHONG THROUGH THE CASE STUDY OF THE RETAIL MARKET IN HANOI CITY".We hope to receive the attention of the Journal to improve the author's article. The author looks forward to receiving the earliest reply from the editor.Sincerely thank!
HUBUNGAN LAMA PAPARAN TELEVISI TERHADAP PERKEMBANGAN MOTORIK HALUS BALITA
Authors: Lontoh Pingkan Fredelia , Suryawan Ahmad , Utami Sri 
Published: July 2021

AbstrakLatar belakang: Televisi merupakan salah satu inovasi teknologi yang sering digunakan oleh setiap orang tidak terkecuali anak balita. Menghabiskan banyak waktu pada tayangan televisi membuat anak-anak kehilangan kesempatan untuk mengeksplor lingkungan dan bermain dengan teman-teman sebayanya sehingga berdampak pada kemampuan motorik anak. Tujuan: Mengetahui hubungan antara lama paparan televisi dengan perkembangan motorik halus anak usia 3-5 tahun. Metode: Penelitian analitik observasional dengan pendekatan cross sectional pada balita usia 3-5 tahun di wilayah kerja Puskesmas Kenjeran Surabaya dengan menggunakan purposive sampling. Lama paparan televisi diukur menggunakan lembar pengumpul data sedangkan perkembangan motorik halus diukur menggunakan KPSP aspek motorik halus. Analisis data menggunakan chi square (p < 0,05). Hasil: sebanyak 108 balita yang ikut serta dalam penelitian. Anak yang menonton > 2 jam/ hari sebagian besar lulus perkembangan motorik halus. Hasil uji chi-square menunjukkan adanya hubungan antara lama durasi paparan televisi dengan kemampuan motorik halus (p=0,042). Kesimpulan: menonton televisi yang tidak terkendali dapat membawa dampak buruk bagi perkembangan motorik halus, diperlukan peran orangtua dalam mengawasi dan membatasi paparan televisi pada anak. AbstractBackground: Television is one of the technological innovations that is often used by everyone is no exception for toddlers. Spending a lot of time on television shows makes children lose the opportunity to explore the environment and play with peers so as to impact the child's motor skills. Objectives: Know the relationship between prolonged television exposure with fine motor development of children aged 3-5 years. Method: Observational analytic research with cross sectional approach in toddlers aged 3-5 years in the working area of Kenjeran Surabaya by using purposive sampling. Prolonged television exposure was measured using a data collector sheet while smooth motorik developments were measured using KPSP fine motor aspects. Data analysis using Chi Square (P < 0.05). Results: As many as 108 toddlers participating in the study. Children watching > 2 hours/day mostly pass fine motor development. The chi-square test results indicate the relationship between the length of the duration of television exposure with fine motor capability (P = 0,042). Conclusion: An uncontrolled television watch can bring a bad impact to the smooth motorik developments, required parental role in supervising and restricting television exposure in children.
HUBUNGAN DISMENOREA PRIMER DENGAN AKTIVITAS BELAJAR PADA SISWI SMAN 8 SURABAYA
Authors: Prastika Anggreini Wahyu , Sari Gadis Meinar , Hardianto Gatut 
Published: July 2021

Abstrak Latar Belakang : Aktivitas belajar merupakan proses belajar, baik kegiatan fisik maupun psikis. Aktivitas belajar siswa dipengaruhi oleh beberapa faktor. Keluhan yang sering dirasakan oleh remaja putri yaitu nyeri saat menstruasi (dismenorea). Dismenorea adalah rasa nyeri perut bagian bawah yang menjalar ke kaki ataupun punggung yang timbul saat atau menjelang haid. Pada anak remaja usia sekolah, dismenorea dapat mengganggu aktivitas belajar sehari-hari. Saat seorang remaja putri mengalami dismenorea, hal tersebut dapat membuat mereka tidak masuk sekolah. Penelitian ini bertujuan untuk mengetahui hubungan antara dismenorea primer dengan aktivitas belajar. Metode : Penelitian ini adalah analitik observasional dengan desain cross sectional di SMAN 8 Surabaya yang dilakukan bulan maret sampai juni 2019. Sampel yang digunakan sebanyak 58 siswi SMAN 8 Surabaya yang diambil dengan metode Purposive Sampling. Data dianalisa menggunakan analisis bivariat menggunakan uji Chi Square. Hasil : Hasil uji statistik menunjukkan tidak ada hubungan yang bermakna antara dismenorea primer dengan aktivitas belajar pada siswi SMAN 8 Surabaya dengan (P 0,834). Kesimpulan : Tidak terdapat hubungan antara dismenorea primer dengan aktivitas belajar.Abstract Background: Learning activities are a learning process both in physical and psychological activities. Student learning activities are influenced by several factors. Complaints that are often felt by female adolescents are menstrual pain (dysmenorrhea). Dysmenorrhea is a pain in the lower abdomen that spreads to the legs or back that arises during or before menstruation. In adolescents, dysmenorrhea can interfere with daily learning activities. When a female adolescents experiences dysmenorrhea, it can make them not attend school. This study aims to determine the relationship between primary dysmenorrhoea and learning activities. Method: This study was an observational analytic with cross sectional design at SMAN 8 Surabaya conducted in March to June 2019. The sample used were 58 female students of SMAN 8 Surabaya taken by purposive sampling method. Data were analyzed using bivariate analysis using the Chi Square test. Result : The results of the statistical test showed there is no significant relationship between primary dysmenorrhea and learning activities in female students of SMAN 8 Surabaya with (P 0.834).Conclusion : There is no relationship between primary dysmenorrhoea and learning activities.
A Coupled Hydrate and Compositional Wellbore Simulator: Understanding Hydrate Inhibition from Associated Brines in Oil and Gas Production
Authors: Coelho Fernando M. C. , Sepehrnoori Kamy , Ezekoye Ofodike A. 
Published: July 2021

Summary
Hydrates are ice-like solids composed of a water-based lattice “encaging” gas molecules. They form under conditions of high pressure and low temperature. In the oil and gas industry, where these conditions are easily met, hydrate formation may cause pipe blockages and severe financial implications, making its prevention (and remediation) one of the main flow-assurance concerns. Desired hydrate inhibition may come from electrolytes naturally dissolved in the water that is produced in conjunction with the hydrocarbon stream, or alcohols can be deliberately injected for such a purpose. When trying to predict hydrate conditions in real-world production systems, computer simulation should ideally integrate hydrate and multiphase-flow calculations. Failing to do so [by performing a decoupled analysis with a flow simulator and a separate pressure/volume/temperature (PVT) package for example] may generate misleading results under certain flow conditions. This paper presents an integrated wellbore simulator to deal with this issue. A hydrate model is added to verify hydrate formation for specific pressure, temperature, and composition of each gridblock. Integration with a geochemical package allows consideration of electrolyte inhibition coming from the associated brine. After successfully comparing results with the available simulators and the experimental data, it is demonstrated that when flowing gas/water ratios (GWRs) exceed 105 scf/STB, water condensation throughout the flow may dilute the beneficial effect arising from the brine composition, thus reducing electrolyte inhibition. Conversely, mineral precipitation along the flow path has shown a nearly negligible impact on this effect.