bluuebunny/crossref_metadata_2025_split huggingface dataset:
ДОСВІД ОРГАНІЗАЦІЇ ДИСТАНЦІЙНОГО НАВЧАННЯ В КИТАЇ
Authors: Доценко С. О.  
Published: May 2021

У статті представлено досвід Китаю, визнаного одним із лідерів у сфері впровадження дистанційної освіти. Завданнями дослідження є висвітлення історії розвитку дистанційної освіти в Китаї, визначення особливостей та шляхів її ефективного впровадження. Методологічну основу становлять концептуальні положення порівняльної педагогіки, питання економічного розвитку в КНР, історичні аспекти розвитку китайської системи освіти, проблеми професійної підготовки вчителів у КНР, історія дистанційної освіти в Китаї. Наведено підходи, які окреслюють аспекти дистанційної освіти: 1) наявність географічної дистанції між учнем та вчителем (студентом або викладачем) у процесі навчання; 2) присутність нового типу освітньої комунікації, який обумовлений поділом процесів викладання та навчання в часі та просторі; 3) вивчення дистанційної освіти як нової технологічної форми навчання, що виникла в інформаційному суспільстві. Визначено три підходи до феномена «дистанційне навчання»: теорія індустріалізації, концепт відстані та характер освітньої комунікації. Застосовано такі методи дослідження як узагальнення та порівняння, які дозволяють вивчати зв’язки між різними підходами; метод класифікації понять; метод критичного мислення та метод прогностичного дослідження.
Акцентовано увагу на використанні масових відкритих онлайн-курсів (MOOC), які користуються попитом у КНР. Наведено переваги MOOC: відкритість, масовість та адаптивність. Окреслено труднощі щодо використання MOOC: відсутність особистісної взаємодії між викладачами та студентами; обмеженість обсягу та різноманітності навчальних ресурсів та справедливість системи оцінювання. Проаналізовано освітні платформи, які надають можливість організації MOOC: «XuetangX» та» iCourse». Новизна дослідження полягає у визначенні ефективних та перевірених засобів організації дистанційного навчання КНР, які можуть бути оперативно апробовані в українській системі освіти.
A Rare Cause of Severe Hypoglycaemia
Authors: Etchie Laju , Fernando Devaka , Muraleedharan Vakkat , Poduval Ashok 
Published: May 2021

A 67-year old woman presented with an unwitnessed fall and decreased oral intake. She had a learning disability, hypertension, epilepsy, asthma, chronic iron deficiency anaemia, mild lymphopenia, osteoporosis and treated uterine cancer. After clinical review, she was treated for Hospital-acquired pneumonia (following a recent hospital admission) with possible aspiration. She was noted to have hyponatraemia secondary to dehydration. She was commenced on intravenous Levofloxacin and Metronidazole along with supportive care, based on antibiotic guidance due to her known allergy to penicillin.On day 3 of admission, she was found unresponsive with a capillary blood glucose of 0.6 mmol/L, which improved with 10% glucose infusion. The low blood glucose was attributed to poor oral intake. However, her serial blood sugar results demonstrated persistent hypoglycaemia for 72h needing further intravenous glucose infusions. A medication review was undertaken and Levofloxacin was discontinued. After 24hrs of discontinuation, the hypoglycaemic episode resolved. A short synacthen test showed a normal cortisol response. There were no further episodes of hypoglycaemia.
Conclusion
As her persistent hypoglycaemia resolved on discontinuation of Levofloxacin, a diagnosis of fluoroquinolone induced hypoglycaemia was reported to MHRA. Fluoroquinolones are thought to induce hypoglycaemia by increasing the insulin release via blockade of adenosine triphosphate-sensitive K+channels in the β cells of the pancreas. This effect may not be clinically evident in all patients because of physiologic mechanisms that regulate blood glucose levels. Health professionals should be aware of the potential risk of severe hypoglycaemia with the use of Fluoroquinolones which are a first or second-line treatment for common infective processes. Fluoroquinolones should be stopped immediately and switch to a non-Fluoroquinolones antibiotic if possible. In elderly patients with compromised oral intake or in those with other comorbidities, regular blood glucose monitoring should be carried out to avoid life-threatening hypoglycaemic episodes.
Two probable human leukocyte antigen haplotypes in association with human leukocyte antigen HLA-DRB1*13
Authors: Mazibuko Nondumiso Ayanda , Yang Kuo-Liang 
Published: May 2021

Objectives:
Here, we show two probable haplotypes associated with the human leukocyte antigen (HLA) DRB1*13:50:01 allele. The haplotypes were observed from 41 randomized unrelated Taiwanese individuals among a population of 23,064 individuals tested.

Materials and Methods:
The samples in this study were blood samples, preserved in dipotassium ethylenediaminetetraacetic acid and/or ACD anticoagulants. The population is of donors from Tzu Chi Bone Marrow Donor Registry. Allele typing was performed using the sequence-based typing method, Sanger's sequencing. To discern the HLA-A and HLA-B alleles, exons 2 and 3 were sequenced. For DRB1 alleles, exon 2 was sequenced. Target exon sequence amplifications were done by a polymerase chain reaction and the resulting amplicons were sequenced by Bigdye Terminator Cycle Sequencing Ready Reaction kit, according to the manufacturer's protocols.

Results:
Two probable haplotypes that are associated with the DRB1*13:50:01 were observed among the 23,064 Taiwanese randomized unrelated individuals. One of the haplotypes is observed in 39 individuals while the other in two individuals.

Conclusion:
The findings in this study may be useful in studies reinforcing the understanding and clinical application of the polymorphism of HLA genes and haplotypes.
Uso de herramientas digitales en la prevención de la violencia contra las mujeres rurales
Authors: QUISPE PUMA FLORENTINO 
Published: May 2021

El uso de herramientas digitales, como los celulares, vienen siendo adaptadas como parte de la cultura comunicativa por las mujeres rurales. El objetivo del presente artículo es describir las características del uso de las herramientas digitales por las mujeres rurales como medio para prevenir y reducir la violencia familiar, a partir de los canales comunicativos como la línea 100 y el chat 100 del Programa Nacional para la prevención y erradicación de la violencia contra las mujeres e integrantes del grupo Familiar – AURORA. Se desarrolló bajo el enfoque cualitativo caracterizado por una revisión bibliográfica de artículos, investigaciones e informes relacionados al tema. Llegamos a la conclusión, de que existe más probabilidad de prevenir y reducir la violencia familiar contra las mujeres rurales si se orienta el uso oportuno de los celulares bajo la metodología de la difusión de mensajes de texto SMS con contenido persuasivo y motivador.
Upaya Mencegah Peningkatan Kejadian Kanker Servik Melalui Sosialisasi Cara Mencegah Kanker Serviks Pada Remaja
Authors: Purbosari Ira , Rahayu Asti , Sari Dewi Perwito , Nuraini Indria 
Published: May 2021

Cervical cancer is a type of cancer with the highest prevalence and mortality rate in women. However, early detection can reduce mortality from cervical cancer significantly and effective screening and treatment of pre-cancerous lesions can reduce the incidence of cervical cancer. Therefore, empowering groups of adolescents in schools and communities in increasing awareness of the importance of knowledge about early detection of symptoms and signs, as well as steps to prevent cervical cancer, as well as management of cervical cancer therapy is needed. The purpose of this activity provided knowledge to adolescents about the dangers of cervical cancer, early detection, prevention, and treatment. This PPM activity was carried out in collaboration with Muhammadiyah 1 high school students Taman Sidoarjo, totaling 58 of 12-grade students using a zoom meeting. The result of this PPM activity was the increase of knowledge between the pre-test and post-test from (39.9%) to (81%). The conclusion was an increase in knowledge of Muhammadiyah 1 Taman Sidoarjo high school students regarding early detection of symptoms and signs, as well as steps to prevent cervical cancer, as well as management of cervical cancer therapy.
Abstrak
Kanker servik merupakan jenis kanker dengan prevalensi dan angka kematian tertinggi pada wanita. Namun, deteksi dini ternyata dapat menurunkan angka kematian akibat kanker servik secara signifikan dan skrining yang efektif serta pengobatan lesi pra-kanker dapat menurunkan angka kejadian kanker serviks. Oleh karena itu, pemberdayaan kelompok anak remaja di lingkungan sekolah dan masyarakat dalam meningkatkan kesadaran akan pentingnya pengetahuan mengenai deteksi dini gejala dan tanda, serta langkah pencegahan kanker serviks, serta management terapi kanker servik sangat dibutuhkan. Tujuan kegiatan ini untuk memberikan pengetahuan kepada remaja tentang bahayanya kanker serviks, cara deteksi dini, pencegahan dan penanganannya. Kegiatan PPM ini dilakukan dengan kerjasama dengan siswi SMU Muhammadiyah 1 Taman Sidoarjo, berjumlah 58 siswi kelas 12 dengan menggunakan zoom meeting. Hasil kegiatan PPM ini terjadinya peningkatan pengetahuan antara pre test dan post test dari (39,9%) menjadi (81%). Kesimpulan Pengabdian Pada Masyarakat ini adanya peningkatan pengetahuan pada siswi SMU Muhammadiyah 1 Taman Sidoarjo mengenai deteksi dini gejala dan tanda, serta langkah pencegahan kanker serviks, serta management terapi kanker servik.
Sosialisasi Stimulasi Produksi Asi Melalui Pijat Oksitosin dan Minyak Esensial Lavender untuk Mencegah Stunting di Desa Gondang Kabupaten Mojokerto
Authors: Rahayu Asti , Purbosari Ira , Tsabitah Aulia Mei 
Published: May 2021

Breastfeeding has a significant role in preventing stunting. The fluency of breastfeeding by postpartum mothers, apart from being influenced by nutritional intake, was also influenced by psychological and environmental factors. Oxytocin massage was part of the way out to increase milk production, minimize swelling and provide comfort to the mother, so that breast milk was stimulated smoothly. The use of lavender oil acts as a relaxant and as an aromatherapy when oxytocin massages provided synergistic benefits on oxytocin massage to stimulate breast milk. Counseling related to the socialization of stimulation of breast milk production through massage of oxytocin and lavender essential oil to prevent stunting in the first 1000 days of birth was carried out in Gondang Village, Gondang District, Mojokerto Regency. The level of knowledge of the participants was measured using a questionnaire and analyzed using a paired sample T test. The analysis results show the sig. 0.000 (p <0.005), which indicates that there was a significant relationship between the provision of counseling materials to the participants insights and knowledge regarding the stimulation of breastfeeding and oxytocin massage using lavender oil, where participants knowledge has increased from before to after exposure to the information
Abstrak
Pemberian ASI (Air Susu Ibu) berperan signifikan dalam pencegahan stunting. Kelancaran ASI oleh ibu pasca melahirkan, selain dipengaruhi oleh asupan nutrisi juga dipengaruhi oleh faktor psikologi dan lingkungan ibu. Pemijatan oksitosin merupakan bagian dari jalan keluar untuk meningkatkan produksi ASI, meminimalisasi pembengkakan dan memberikan rasa nyaman pada ibu, sehingga ASI terstimulasi lancar. Penggunaan minyak lavender berfungsi sebagai relaksan dan sebagai aromaterapi saat melakukan pijat oksitosin memberikan manfaat secara sinergis pada pijat oksitosin untuk menstimulasi ASI. Penyuluhan terkait sosialisasi stimulasi produksi asi (Stipasi) melalui pijat oksitosin dan minyak esensial lavender untuk mencegah stunting pada 1000 hari pertama kelahiran dilakukan di Desa Gondang, Kecamatan Gondang, Kabupaten Mojokerto. Tingkat pengetahuan peserta diukur menggunakan kuisioner dan dianalisa dengan uji T sampel berpasangan. Hasil analisa menunjukkan nilai sig. 0.000 (p < 0,005) yang menunjukkan terdapat hubungan bermakna antara pemberian materi penyuluhan terhadap wawasan dan pengetahuan peserta terkait stimulasi pemberian ASI dengan pijat oksitosin menggunakan minyak lavender, dimana pengetahuan peserta mengalami peningkatan dari sebelum hingga setelah di paparkan materi penyuluhan.
Strategi Pemerintah Desa dalam Meningkatkan Perekonomian Masyarakat Desa Putat Kecamatan Sedong Kabupaten Cirebon
Authors: Sya'roni Mohamad Mizan , Husna Resya Zauharotul , Nugraha Iman 
Published: May 2021

The purpose of this study was (1)to determine the condition of the Putat village area (2) to determine the economic condition of the Putat village community (3) to determine what strategies the Putat village government had taken to improve the community economy. This study uses a descriptive method with a qualitative approach, the researcher as the key instrument, the data analysis is inductive, and the research results emphasize the meaning rather than the generalization of the object. The data collection techniques used were observation, in-depth interviews, and documentation. The findings of this study are: First, the territory of Putat village is a brief history of Putat village, its geographical location, population, and community culture. Second, the economic condition of the people of Putat Village. Third, the strategies carried out by the village government which aim to improve the economy of the people of Putat village, including: Revitalizing BUMDES and creating social media.
Abstrak
Tujuan dalam penelitian ini adalah (1) untuk mengetahui kondisi wilayah desa Putat (2) untuk mengetahui keadaan perekonomian masyarakat desa Putat (3) untuk mengetahui strategi apa yang dilakukan pemerinatah desa Putat untuk meningkatkan perekonomian masyarakat. Penelitian ini menggunakan metode deskriptifdengan pendekatan kualitatif, peneliti sebagai instrumen kunci, analisis data bersifat induktif, dan hasil penelitian lebih menekankan makna daripada generalisasi objek. Teknik pengumpulan data yang digunakan adalah observasi, wawancara mendalam, dan dokumentasi. Temuan dari penelitian ini adalah: Pertama,Konsisi wilayah desa Putat berupa sejarah singkat desa Putat, letak geografis, kependudukan, dan budaya masyarakat.Kedua,Keadaan perekonomian masyarakat Desa Putat. Ketiga, strategi-strategi yang dilakukan pemerintah desa yang bertujuan untuk meningkatkan perekonomian masyarakat desa Putat, diantaranya: Revitalisasi BUMDES dan pembuatan media sosial.
Pemberdayaan Ekonomi Masyarakat Melalui Dunia Digital di Era Covid-19
Authors: Taufiqurrahman Taufiqurrahman , Azis Abdul , Sugita Ades 
Published: May 2021

Community empowerment in the midst of the Covid-19 pandemic, one of which is by introducing the use of digital marketing for MSME players. Digital marketing is a promotional activity and market search through online digital media by utilizing various means such as social networks and online product or service sales platforms. This research is a qualitative research with the aim of identifying the impact of digital marketing and the obstacles that occur in marketing products through digital marketing. The method of data collection is done by observation and interview techniques. The method of determining informants is carried out by snowball sampling to umkm entrepreneurs based on local food, handicraft, bumdes and maggot cultivation. The results show that MSME players are interested in using digital marketing and utilizing social media, but there are still some obstacles they experience such as low technology skills, they think that promoting products to digital marketing through social media and market places is something that is important. troublesome / complicated, the availability of internet access is limited, there are still many consumers who are worried about the security of transacting online..
Abstrak
Pemberdayaan masyarakat di tengah pandemi covid-19 salah satunya dengan memperkenalkan pemanfaatan digital marketing bagi pelaku UMKM. Digital marketing adalah kegiatan promosi dan pencarian pasar melalui media digital secara online dengan memanfaatkan berbagai sarana misalnya jejaring sosial dan platform penjualan produk atau jasa online. Penelitian ini merupakan penelitian kualitatif dengan tujuan mengidentifikasi dampak digital marketing dan kendala yang terjadi dalam memasarkan produk melalui digital marketing. Metode pengambilan data dilakukan dengan teknik observasi dan wawancara. Adapun metode penentuan informan dilakukan secara snowball sampling kepada pengusaha umkm berbasis pangan lokal , handycraft, bumdes dan budidaya maggot. Hasil penelitian menunjukkan bahwa para pelaku UMKM tertarik untuk menggunakan digital marketing dan memanfaatkan media social, akan tetapi masih ada beberapa kendala yang mereka alami seperti kemampuan teknologi masih rendah, mereka menganggap bahwa untuk mempromosikan produk ke digital marketing melalui sosial media dan market place adalah hal yang menyusahkan/ribet, ketersediaan akses internet yang terbatas, masih banyak konsumen yang mengkhawatirkan keamanan bertransaksi secara online.
Pemberdayaan Bibit Mangrove Sebagai Alternatif Edukasi Pengembangan Wisata Di Desa Muara Kecamatan Suranenggala Kabupaten Cirebon
Authors: Putri Vany Dwi , Tapsila Tapsila , Septimia Linda 
Published: May 2021

Coastal areas tend to experience soil erosion along the coast, as a result floods often occur due to this. As a result, land on the edge of a river near the sea experiences soil erosion, although the impact is not too big, if left unchecked, it will result in flooding in the future. Therefore, we are trying to plant mangroves with the aim of opening up insights on the importance of environmental conservation and how to maintain the balance of the ecosystem in it and to hone care for the river area in Muara Village. Apart from its usefulness as preventing soil abrasion or erosion, mangroves also have their own aesthetic beauty. . The method used in this activity was counseling on the use of mangrove trees and mangrove tree planting practices. The counseling stage in the form of material delivery and mangrove planting practices was carried out in the Bengawan Celancang river, Muara Village, Suranenggala District, Cirebon Regency. With the activities that we carry out, it is intended that every resident of Muara Village can pay more attention to the mangrove ecosystem. As well as being an inspiration for other villages that are located on the coast of Cirebon Regency.
Abstrak
Daerah pesisir cenderung mengalami pengikisan tanah di pinggir pantai, akibatnya tidak jarang terjadinya banjir karena hal tersebut. Tanah yang ada di pinggir sungai dekat laut akibatnya mengalami pengikisan tanah, meski dampaknya tidak terlalu besar, namun jika dibiarkan akan mengakibatkan kebanjiran di kemudian hari. Maka dari itu, kami mengupayakan penanaman mangrove bertujuan untuk membuka wawasan akan pentingnya kelestarian alam lingkungan dan bagaimana menjaga keseimbangan ekosistem di dalamnya serta mengasah kepedulian terhadap daerah sungai di Desa Muara.Selain karena kegunaannya sebagai mencegah abrasi atau pengikisan tanah, mangrove juga memiliki keindahan estetika tersendiri.Metode yang digunakan dalam kegiatan ini adalah penyuluhan mengenai pemanfaatan pohon mangrove dan praktik penanaman pohon mangrove. Tahap penyuluhan berupa penyampaian materi dan praktik penanaman mangrove dilaksanakan di sungai Bengawan Celancang Desa Muara Kecamatan Suranenggala Kabupaten Cirebon. Dengan adanya kegiatan yang kami lakukan ini bertujuan agar setiap warga Desa Muara dapat lebih memperhatikan ekosistem mangrove. Serta dapat menjadi inspirasi bagi Desa-desa lain yang letaknya berada di pinggir pantai
Shikonin treatment ameliorates Lipopolysaccharides (LPS) induced acute liver failure in mice via regulating the miR-106/MCL1 and miR-34a/SIRT1/TP53 signaling
Authors: Huang Fan , Hai Hua , Gao Buwei 
Published: May 2021

IntroductionThe treatment with shikonin (SKN) suppresses the expression of miR-106 and miR-34a. Furthermore, SIRT1 and MCL1 are targets of miR-34a and miR-106, respectively. In this study, we treated an animal model of ALF with high dose (1.0 mg/kg) and low dose (0.5 mg/kg) of SKN to investigate its effect on liver functions and signaling pathways of SKN/miR-106/MCL1 and SKN/miR-34a/SIRT1/TP53.Material and methodsALF animal model was established and the serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analyzed to evaluate the effects of different doses of SKN. TUNNEL was performed to assess hepatocyte apoptosis. Luciferase assay, RT-qPCR and Western blot analysis were performed to measure the relationship between miR-106, miR-34a, SIRT1 and MCL1.ResultsIn the ALF mice models, the administration of SKN decreased the levels of ALT and AST in a dose-dependent manner, along with a significantly decreased number of apoptotic hepatocytes. And SKN may protect liver during ALF via reducing the level of inflammation. Luciferase assay showed that the co-transfection of wild-type MCL1/SIRT1 and miR-106/miR-34a significantly decreased the luciferase activity of LO2 cells, thus indicating that MCL1 and SIRT1 are identified as targets of miR-106 and miR-34a, respectively, while SIRT1 could act as a regulator of TP53. Moreover, the expression of miR-106, miR-34a and TP53 was decreased over an increasing concentration of SKN, along with the increasing mRNA and protein levels of MCL1 and SIRT1.ConclusionsIn this study, we showed that SKN alleviated ALF in a dose-dependent manner via regulating the signaling pathways of SKN/miR-106/MCL1 and SKN/miR-34a/SIRT1/TP53.
SCHATTEN-TYPE CLASSES ON SEQUENCE SPACES
Authors: KHALIL R. , SALEH M. 
Published: May 2021

Let $H$ be a Hilbert space and $L(H)$ be the bounded linear operators on $H$. For $T\in L(H)$, let
$$||T||_P=\sup\left[\sum_{n=1}^\infty|<Te_n, e_n>|^p\right]^{1/p},$$
where the supremum is taken over all orthonormal sequences $(e_n)$. Set $C_p(H)=\{T\in L(H) : ||T||_p<\infty\}$. The object of this paper is to define and study $C_p(X , Y)$ where $X$ and $Y$ are sequences spaces