bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics, risk factors and outcomes of gastrointestinal hemorrhage in COVID-19 patients: A meta-analysis
Authors: Chen Jie , Hang Ying 
Published: July 2021

Meta Analysis/Original Research
Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a cause of coronavirus disease 2019 (COVID-19), mainly targets the respiratory system. However, recent studies also show its role in causing gastrointestinal hemorrhage, potentially affecting morbidity and mortality-related outcomes of the patients. There is still no consensus on the risk factors, characteristics, and the overall outcome of the gastrointestinal hemorrhage in COVID-19 patients. The main aim of this study was to summarize current evidence, assessing risk factors that promote the onset of gastrointestinal hemorrhage in COVID-19 patients, and to compare the incidences of the different sites of gastrointestinal lesions, the events of abdominal pain, diarrhea, intensive care unit admissions, and mortality between COVID-19 patients with or without gastrointestinal bleeding.
Methods: A search of the academic literature was performed according to the PRISMA guidelines across five databases i.e., Web of Science, EMBASE, CENTRAL, Scopus, and MEDLINE. A random-effect meta-analysis was conducted to analyze the influence of the history of drugs consumption, gastrointestinal bleeding, the different incidence of gastrointestinal lesions, events of abdominal pain, intensive care unit (ICU) admission, and mortality between COVID-19 patients with/without gastrointestinal bleeding.
Results: Out of 458 studies, three eligible studies with 663 participants (mean age: 69.7 ± 4.3 years) were included. A meta-analysis showed a medium-to-large influence of the history of gastrointestinal bleeding (Hedge’s g: 1.01) and anticoagulant drug consumption (g: 0.33) on the gastrointestinal bleeding in COVID-19 patients. Moreover, the incidence of gastroduodenal ulcers was higher as compared to esophagitis (37.5% versus 9.9%).
Conclusions: The study provides preliminary evidence regarding the risk factors associated with the onset of gastrointestinal hemorrhage among COVID-19 patients. The study also outlines the characteristics and the outcomes of gastrointestinal hemorrhage in COVID-19 patients.
doi: https://doi.org/10.12669/pjms.37.5.4351
How to cite this:Chen J, Hang Y. Characteristics, risk factors and outcomes of gastrointestinal hemorrhage in COVID-19 patients: A meta-analysis. Pak J Med Sci. 2021;37(5):1524-1531. doi: https://doi.org/10.12669/pjms.37.5.4351
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The history of surgery and surgical training in the UK
Authors: Payne Thomas , Toms Joseph D. , Zaidi Ahsan , Thrumurthy Sri G. 
Published: July 2021

Surgery has a rich history, and in order to understand the various training pathways for aspiring surgeons one must have an appreciation of the evolution of surgery. This manuscript aims to deliver a brief review of the history of surgery, and explore the historical moments that have shaped the training pathway of surgeons in the United Kingdom (UK), and in doing so disseminate the latest information about surgical training in the UK.
doi: https://doi.org/10.12669/pjms.37.5.4628
How to cite this:Payne T, Toms JD, Zaidi A, Thrumurthy SG. The history of surgery and surgical training in the UK. Pak J Med Sci. 2021;37(5):1532-1535. doi: https://doi.org/10.12669/pjms.37.5.4628
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Burden of VSD associated aortic valve cusp prolapse with aortic regurgitation and the impact of early surgery on clinical outcomes in South Asia
Authors: Saeed Sahrai , Emmanuel Yaso 
Published: July 2021

doi: https://doi.org/10.12669/pjms.37.5.4845
How to cite this:Saeed S, Emmanuel Y. Burden of VSD associated aortic valve cusp prolapse with aortic regurgitation and the impact of early surgery on clinical outcomes in South Asia. Pak J Med Sci. 2021;37(5):1259-1261. doi: https://doi.org/10.12669/pjms.37.5.4845
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Mengurangi keterbukaan hutan melalui teknik pemananenan kayu yang tepat di hutan alam
Authors: Yuniawati Yuniawati , Margareth Tampubolon Rossi 
Published: July 2021

Kegiatan pemanenan kayu memberikan kontribusi yang sangat besar terhadap produksi kayu. Pohon produksi yang berada di dalam hutan tidak dapat dimanfaatkan jika tidak ditebang dan tidak dikeluarkan dari dalam hutan. Metode penelitian ini adalah membuat 6 plot contoh pengamatan (PCP) masing-masing 3 PCP untuk teknik perbaikan (TP) dan 3 PCP untuk teknik konvensional (TK) pada satu petak tebang, melakukan penebangan pohon dan penyaradan dengan TP dan TK, melakukan pengamatan dan pengukuran produktivitas pemanenan kayu dan luas areal hutan yang terbuka akibat penebangan dan penyaradan serta menganalisis pengaruh kedua teknik terhadap produktivitas areal hutan terbuka dengan uji t. Tujuan penelitian adalah untuk mengetahui pengaruh dua teknik pemanenan kayu terhadap produktivitas dan areal hutan terbuka. Hasil penelitian menunjukkan bahwa : 1) Rata-rata produktivitas penebangan dengan TK dan TP masing-masing adalah 10,60 m3/jam dan 13,95 m3/jam 2) Rata-rata produktivitas penyaradan dengan TK dan TP masing-masing adalah 7,25 m3/jam dan 9,60 m3/jam; 3) Rata-rata areal hutan terbuka akibat penebangan dengan TK dan TP masing-masing adalah 15,67% dan 7,43% ; 4) Rata-rata areal hutan terbuka akibat penyaradan dengan TK dan TP masing-masing adalah 10,50% dan 6,68%. Menerapkan teknik perbaikan dapat mengurangi terjadinya keterbukaan hutan pada penebangan dan penyaradan masing-masing sebesar 8,24% dan 3,82%.ABSTRACTTimber harvesting provides a very large contribution to timber production. Tree production that is in the forest can't be used if they are not felling and removed from the forest. This research method is to make 6 sample observation plot (SOP) each 3 SOP for improving technique (IT) and 3 SOP for conventional technique (CT) on one logging compartment, do felling and skidding by IT and CT, make observations, and measuring the productivity of timber harvesting and the area of open forest due to felling and skidding and analyzing the effect of the two techniques on the productivity of the open forest area with t-test. The research objective was to determine the effect of two timber harvesting techniques on productivity and open forest areas. The results showed that the average productivity of felling by CT and IT was 10.60 m3/hour and 13.95 m3/hour respectively. The average productivity of skidding by CT and IT was 7.25 m3/hour and 9.60 m3/hour respectively. The average open forest area due to felling by CT and IT was 15.6% and 7.43% respectively. The average open forest area due to skidding by CT and IT was 10.50% and 6.68% respectively. Applying improve technique reduced the open forest area through felling and skidding by 8.24% and 3.82% respectively.
Study on the frequency of acoustic emission signal during crystal growth of salicylic acid
Authors: Wang Xingjun , Xie Quanmin , Huang Ying 
Published: July 2021

AbstractBased on the results of the previous experiment, this article studied the acoustic emission (AE) signals released during the crystallization of salicylic acid to establish the relationship between the AE signal and the particle size. A tremendous amount of acoustic data was analyzed using time–frequency domain analysis methods in order to extract the valuable contents. Based on the diffusion theory, the vibratory model between the AE signal and the crystal particle size was established. This article mainly studies the process of small particles diffusing to the growth point by impact, adding to the lattice, and the crystal releases energy. The impact of the growth unit on particle aggregate is equivalent to a linear elastic vibration system with one end fixed and the other end free. The vibration frequency is 200–355 kHz when the particle size is between 600 and 1,100 µm. The calculated vibration frequency is in good agreement with the measured frequency.
The Leu72Met (rs696217 G>T) Polymorphism of the Ghrelin Gene Might Be a Protective Factor for Nonalcoholic Fatty Liver Disease
Authors: Tabaeian Seidamir Pasha , Mahmoudi Touraj , Sabzikarian Mohammad , Rezamand Gholamreza , Dabiri Reza , Nobakht Hossein , Asadi Asadollah , Farahani Hamid , Mansour-Ghanaei Fariborz , Zali Mohammad Reza 
Published: July 2021

Background and Aims: Nonalcoholic fatty liver disease (NAFLD) is a growing problem and the commonest cause of chronic liver disease throughout the world. Given the strong association between NAFLD and insulin resistance and obesity, as well as the central role of ghrelin in these metabolic disorders, we explored whether ghrelin (GHRL) and ghrelin receptor (GHSR) gene polymorphisms were associated with susceptibility to NAFLD.
Methods: In this case-control retrospective study which was conducted between April 2010 and July 2013, GHRL (rs696217 or Leu72Met) and GHSR (rs2922126) gene polymorphisms were genotyped in 153 cases with biopsy-proven NAFLD and 157 controls using the polymerase chain reaction - restriction fragment length polymorphism method.
Results: The GHRL rs696217 “GT+TT” genotype or “GT” genotype compared with the “GG” genotype occurred less frequently in the patients with NAFLD than the controls and the differences remained significant after adjustment for confounding factors such as age and body mass index (p=0.018; OR=0.35, 95%CI: 0.14–0.84 and p=0.046; OR=0.40, 95%CI: 0.16–0.98, respectively). Furthermore, the GHRL rs696217 ‘T’ allele compared with ‘G’ allele was significantly underrepresented in the cases (p=0.007; OR=0.33, 95%CI: 0.15-0.76). Nevertheless, no significant difference was found for GHSR rs2922126 gene polymorphism.
Conclusions: Our findings suggested, for the first time, that the GHRL rs696217 or Leu72Met “GT+TT” genotype and “GT” genotype compared with “GG” genotype, as well as the “T” or Met72 allele compared with “G” or Leu72 allele had a protective effect for NAFLD susceptibility. However, other studies are required to confirm these findings.
Validation of the Reflux Disease Questionnaire for a Turkish Population
Authors: Hançerlioğlu Sadık , Bor Serhat 
Published: July 2021

Background and Aims: Achieving the correct diagnosis and therapeutic success in gastroesophageal reflux disease (GERD) depends on the patient‘s self-assessment. Therefore, valid and reliable patient-reported questionnaires are very important. When designing such measurement tools, researchers should focus on their validity, reliability, sensitivity, and, applicability. The reflux disease questionnaire (RDQ) largely meets these important requirements. This study aims to examine The RDQ’s psychometric characteristics for the Turkish society (RDQ TR ) and its validity in symptoms’ evaluation.
Methods: The sample of this study comprised 81 patients who were admitted to our institution, GERD study group outpatient clinic. The data collection forms used in the study were the case report forms and RDQ. Three weeks after the first interview, 30 patients were re-interviewed by the phone and the RDQ was re-administered. For the validity studies of the scale, language validity, content validity, and construct validity studies were used, and for the reliability studies, internal consistency and test-retest reliability methods were used.
Results: The content validity index of form was 0.95 (0.93-0.98). The performed factor analysis indicated 3 factors with an eigenvalue over 1.0. Those factors were responsible for 77.66% of the variance. The Cronbach‘s alpha values were 0.88 for regurgitation sub-dimension, 0.91 for dyspepsia sub-dimension, 0.86 for heartburn sub-dimension, and 0.92 overall. Intraclass correlation coefficient value of the scale was 0.94.
Conclusions: Our study highlights that the RDQ TR is reliable, valid, and responsive to change in Turkey patients with GERD symptomatology.
Validation and Performance of Chronic Liver Disease Questionnaire (CLDQ-RO) in the Romanian Population
Authors: Taru Vlad , Indre Madalin Gabriela , Ignat Mina Dana , Forgione Antonnela , Racs Tamas , Olar Bianca Alina , Farcau Oana , Chereches Razvan , Stefanescu Horia , Procopet Bogdan 
Published: July 2021

Background and Aims: Health-related quality of life is an essential part of managing chronically ill patients, including patients with chronic liver disease. Various methods are used to try to assess the quality of life ranging from generic to disease-specific questionnaires. Some of the results may reveal a novel connection to the disease‘s evolution, which is observed directly by the patient. This study aimed to validate and assess the chronic liver disease questionnaire (CLDQ-RO) performance in the Romanian population.
Methods: A two-phase study was designed. The first phase consisted of linguistic validation of CLDQ-RO (translation and piloting), while in the second phase, the questionnaire was applied to patients with various chronic liver diseases. Statistical validation (reliability, structural, and construct validity) was performed using SPSS v20.0, and statistical significance was considered p<0.05.
Results: The CLDQ-RO was applied to 231 patients with chronic liver disease (14.3% with chronic hepatitis, 35.5% with compensated cirrhosis, and 50.2% with decompensated cirrhosis). The questionnaire showed excellent overall reliability (Cronbach‘s alpha=0.93) and good structural and construct validity, with most of the items in CLDQ-RO fitting in the domains of the original version of the questionnaire. There was a significant decrease in the overall score of the CLDQ-RO with the progression of disease (p<0.001), indicating a substantial impact of the decompensation event on health-related quality of life. Regarding the type of decompensation, ascites accurately predicted a lower quality of life (p=0.004).
Conclusions: The CLDQ-RO is a valid and disease-specific method for assessing patients‘ health-related quality of life with liver disease. Among the decompensation events, it seems that ascites seriously impacts the quality of life.
Shari‘a a Customary Law?: An Analytical Assessment from The Nigerian Constitution and Judicial Precedents
Authors: Busari Jamiu Muhammad 
Published: July 2021

Under the Nigerian legal classification, shari‘a, the Islamic legal system is classified as customary law. It is on these premises that the Muslims’ agitations for full-fledge shari‘a applications and declassification from being a customary law are always thwarted and termed “unconstitutional” by the shari’a antagonists while the Muslims and protagonists viewed the problems as judicial misinterpretations and legal incongruity. In this study, with the adoption of an analytical approach, shari‘a and customary law are assessed from the provisions of the Nigerian Constitutions and some judicial precedents to unravel the actual position of shari‘a. It was then discovered that, despite the classification under the Nigerian legal system, shari‘a could not have been a customary law due to some factors which include its sources, divinity, permanency and universality.AbstrakDalam hukum Nigeria, hukum Islam atau syariah diklasifikasikan sebagai hukum adat. Premis itulah yang menjadi agitasi upaya penerapan syariah secara penuh oleh umat Islam. Usaha untuk pendeklasifikasi hukum adat selalu digagalkan dan dianggap “inkonstitusional” oleh penentang syariah. sementara sebagian Muslim dan pendukung syariah memandang masalah tersebut sebagai salah tafsir yudisial dan ketidaksesuaian hukum. Dalam penelitian ini, dengan memakai pendekatan analitis, syariah dan hukum adat dinilai untuk mempertegas dalam ketentuan Konstitusi Nigeria berdasar beberapa preseden yudisial untuk mengungkap posisi syariah yang sebenarnya. Kemudian ditemukan bahwa, meskipun klasifikasi di bawah sistem hukum Nigeria, syariah tidak bisa menjadi hukum adat karena beberapa faktor yang meliputi sumbernya, keilahian, keabadian, dan universalitas.
The Dialectics of Customary Law and Islamic Law: An Experience from Dou Donggo Customs of Bima, Indonesia
Authors: Mutawali Muhammad 
Published: July 2021

This article aimed to critically study the shift of Donggo Customs and traditions due to its dialectics with Islamic law. The Donggo customary law was based on the traditional practices and local wisdom of their ancestors, who were believed to have noble values and truth. Since the 17th Century, the dialectics signified by the Bima kingdom’s political system changes from the old customs into Islamic law. This has influenced all aspects of the Bima people’s live, including the Donggo community. The is qualitative research, with data from interviews and a document study. The present study reveals that the Donggo Community’s customary law, preserved and practiced today, results from dialectics between customary law and Islamic law. The practiced traditions include baja sentence, the flogging law, the Mbolo weki culture, Maja Labo dahu and Raju ritual. In Islamic law, such traditions are called `urf or al-`adah, which are living traditions in a society used as legal sources and recognized by Islamic legal scholars. Adat or customary law implemented by the Donggo indigenous people is considered substantially similar to Islamic teachings. So, Donggo customs, corresponding with the Islamic law (`urf shahih), are maintained, while the contradicting ones (`urf fasid) are abandoned. Abstrak:Artikel ini bertujuan untuk mengkaji secara kritis pergeseran adat dan tradisi Donggo sebagai proses dialektika dengan hukum Islam. Hukum adat Donggo didasarkan pada praktik tradisional dan kearifan lokal nenek moyang mereka, yang diyakini memiliki nilai-nilai luhur dan kebenaran. Sejak abad ke-17, dialektika yang ditandai dengan sistem politik kerajaan Bima berubah dari adat lama menjadi hukum Islam. Hal ini telah mempengaruhi seluruh aspek kehidupan masyarakat Bima, termasuk masyarakat Donggo. Jenis penelitian ini adalah kualitatif, dengan data dari wawancara dan studi dokumen. Kajian ini mengungkapkan bahwa hukum adat Masyarakat Donggo yang dilestarikan dan dipraktikkan hingga saat ini, merupakan hasil dari dialektika antara hukum adat dan hukum Islam. Tradisi yang dipraktikkan antara lain hukuman baja, hukum cambuk, budaya weki Mbolo, ritual Maja Labo dahu dan Raju. Dalam hukum Islam, tradisi semacam itu disebut `urf atau al-`adah, yaitu tradisi yang hidup dalam masyarakat yang dijadikan sumber hukum dan diakui oleh para sarjana hukum Islam. Adat atau hukum adat yang dilaksanakan oleh masyarakat adat Donggo secara substansi dianggap mirip dengan ajaran Islam. Jadi, adat Donggo yang sesuai dengan syariat Islam (`urf shahih) tetap dipertahankan, sedangkan yang bertentangan (`urf fasid) ditinggalkan.
Children Handling Procedure in Islamic Criminal Offense in Aceh
Authors: Analiansyah Analiansyah , Abubakar Ali 
Published: July 2021

The Law of the Republic of Indonesia authorizes Aceh to implement shari’a law in various sectors, including jināyāt (Islamic criminal law). The Aceh Government issued qanuns (Regional Bylaws) which cover several jarimah (criminal acts), and its implementation becomes the authority of Shari’a Courts (Mahkamah Syar’iyyah) in Aceh. This additional authority is different from the authority of the Religious Courts (Pengadilan Agama) in other provinces in Indonesia. Judges in those courts do not receive any special education in criminal law, especially cases involving children that have been regulated in a special law. The additional authority in examining and adjudicating criminal cases for Shari’a Court has led to a new Human Resources (HR) problem. This article analyzes the process of handling children in shari’a Courts in Aceh using the lex specialis derogate legi generalis and the systematic lex specialis principles. The results show that the handling of Islamic criminal offenses involving children has been carried out by referring to existing laws and regulations according to the principle of specificity. Some weaknesses in human resources and infrastructure can be appropriately resolved by the Shari’a Courts and the Aceh Government. Abstrak:Undang-Undang Republik Indonesia memberikan kewenangan kepada Aceh untuk menerapkan syariat Islam di berbagai bidang, termasuk jināyāt (hukum pidana Islam). Pemerintah Aceh mengeluarkan qanun (Peraturan Daerah) yang mencakup beberapa jarīmah (perbuatan pidana) dan pelaksanaannya menjadi kewenangan Pengadilan Syariah (Mahkamah Syar’iyyah) di Aceh. Kewenangan tambahan ini berbeda dengan kewenangan Peradilan Agama di provinsi lain di Indonesia. Hakim-hakim di pengadilan-pengadilan tersebut tidak mendapatkan pendidikan khusus dalam hukum pidana, terutama kasus-kasus yang melibatkan anak-anak yang telah diatur dalam undang-undang khusus. Kewenangan tambahan dalam memeriksa dan mengadili perkara pidana di Mahkamah Syariah menimbulkan persoalan Sumber Daya Manusia (SDM) baru. Artikel ini menganalisis proses penanganan anak di Pengadilan Syariah di Aceh dengan menggunakan prinsip lex specialis derogate legi generalis dan systematic lex specialis. Hasil penelitian menunjukkan bahwa penanganan tindak pidana Islam yang melibatkan anak telah dilakukan dengan mengacu pada peraturan perundang-undangan yang ada sesuai dengan asas kekhususan. Beberapa kelemahan sumber daya manusia dan infrastruktur dapat diselesaikan dengan baik oleh Pengadilan Syariah dan Pemerintah Aceh.