bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of chronic axial back pain with 60‐day percutaneous medial branch PNS: Primary end point results from a prospective, multicenter study
Authors: Gilmore Christopher A. , Desai Mehul J. , Hopkins Thomas J. , Li Sean , DePalma Michael J. , Deer Timothy R. , Grace Warren , Burgher Abram H. , Sayal Puneet K. , Amirdelfan Kasra , Cohen Steven P. , McGee Meredith J. , Boggs Joseph W. 
Published: July 2021

AbstractBackgroundThe objective of this prospective, multicenter study is to characterize responses to percutaneous medial branch peripheral nerve stimulation (PNS) to determine if results from earlier, smaller single‐center studies and reports were generalizable when performed at a larger number and wider variety of centers in patients recalcitrant to nonsurgical treatments.Materials & MethodsParticipants with chronic axial low back pain (LBP) were implanted with percutaneous PNS leads targeting the lumbar medial branch nerves for up to 60 days, after which the leads were removed. Participants were followed long‐term for 12 months after the 2‐month PNS treatment. Data collection is complete for visits through end of treatment with PNS (primary end point) and 6 months after lead removal (8 months after start of treatment), with some participant follow‐up visits thereafter in progress.ResultsClinically and statistically significant reductions in pain intensity, disability, and pain interference were reported by a majority of participants. Seventy‐three percent of participants were successes for the primary end point, reporting clinically significant (≥30%) reductions in back pain intensity after the 2‐month percutaneous PNS treatment (n = 54/74). Whereas prospective follow‐up is ongoing, among those who had already completed the long‐term follow‐up visits (n = 51), reductions in pain intensity, disability, and pain interference were sustained in a majority of participants through 14 months after the start of treatment.ConclusionGiven the minimally invasive, nondestructive nature of percutaneous PNS and the significant benefits experienced by participants who were recalcitrant to nonsurgical treatments, percutaneous PNS may provide a promising first‐line neurostimulation treatment option for patients with chronic axial back pain.
Introduction to the Special Issue: Citizenship as a Tool of Government in Europe
Authors: Barrault‐Stella Lorenzo , Douniès Thomas 
Published: July 2021

The state participates in shaping and transmitting citizenship. From a European outlook, this special Issue of Politics & Policy focuses on the role of public policy, according to a comparative and multisectorial perspective. The special Issue originated in a Panel held on September 4, 2019 at the European Consortium of Political Research's General Conference, at the University of Wroclaw, Poland. The articles in this special Issue draw from a plurality of methods, from sociohistory to policy ethnography, and analyze how the state, in the concrete conception and implementation of its action, is a producer of social categorizations determining the legitimate contours of citizenship. Altogether, the case studies in this issue allow us to scrutinize the government of and by citizenship, meanwhile identifying discrepancies and invariants in Europe.Related Articles in this Special Issue:Barrault‐Stella, Lorenzo, and Thomas Douniès. 2021. “From Good ‘User’ to Good Citizen? The Political Effects on Families of Education Policies in France.” Politics & Policy 49 (4).Ewert, Benjamin. 2021. “Citizenship as a Form of Anticipatory Obedience? Implications of Preventive Health Policy in Germany.” Politics & Policy 49 (4).Skowronska, Kaja. 2021. “The Recent Politicization of Immigration in Poland in Light of Preexisting State Practices: Continuity or Change in the Understanding of Citizenship and Nationhood?” Politics & Policy 49 (4).
A new comparison between holographic dark energy and standard $$\varLambda $$-cosmology in the context of cosmography method
Authors: Pourojaghi Saeed , Malekjani Mohammad 
Published: July 2021

AbstractThe cosmography method is a model-independent technique used to reconstruct the Hubble expansion of the Universe at low redshifts. In this method, using the Hubble diagrams from Type Ia Supernovae (SNIa) in Pantheon catalog, quasars and Gamma-Ray Bursts (GRB), we put observational constraints on the cosmographic parameters in holographic dark energy (HDE) and concordance $$\varLambda $$
Λ
CDM models by minimizing the error function $$\chi ^2$$

χ
2

based on the statistical Markov Chain Monte Carlo (MCMC) algorithm. Then, we compare the results of the models with the results of the model-independent cosmography method. Except for the Pantheon sample, we observe that there is a big tension between standard cosmology and Hubble diagram observations, while the HDE model remains consistent in all cases. Then we use different combinations of Hubble diagram data to reconstruct the Hubble parameter of the model and compare it with the observed Hubble data. We observe that the Hubble parameter reconstructed from the model-independent cosmography method has the smallest deviation from the Hubble data and the $$\varLambda $$
Λ
CDM (HDE) model has the largest (middle) deviation, especially when we keep the observational data point $$226^{+8.0}_{-0.8}$$

226

-
0.8

+
8.0

at redshift $$z=2.36$$

z
=
2.36

in the analysis. On the contrary, in the redshift $$z <1$$

z
<
1

, we see that the compatibility of $$\varLambda $$
Λ
CDM cosmology and observation is even better than the model independent cosmography method.
Culpa e sátira no divã: duas crônicas jornalisticas de Sayed Kashua
Authors: Schlesinger Juliana Portenoy 
Published: July 2021

Neste artigo, são analisadas duas crônicas jornalísticas do escritor árabe israelense Sayed Kashua publicadas no jornal Haaretz. Nelas, um embate entre uma sociedade radical e racista e a herança ética e moral dos idealizadores do Sionismo, segundo a qual os árabes receberiam direitos iguais aos da popula-ção judaica, encontram-se como pano de fundo de histórias tão satíricas quanto trágicas. O preconceito contra o árabe permeia as situações pelas quais passa o eu do cronista, mas cabe ao leitor decidir se ele é apenas uma possibilidade que poderia ser vivenciada, se ele de fato está presente nas relações do árabe na sociedade judaico israelense à sua volta ou se estas são alternativas que se complementam.
Besseter Raam de Mêndele Mocher Sfórim e o Renascimento da Língua Hebraica
Authors: Steinberg Gabriel 
Published: July 2021

O surgimento da Haskalá no final do século XVIII foi o fato que possibilitou o renascimento da literatura hebraica de caráter secular e que, posteriormente, permitiu o renascimento dohebraico falado na Terra de Israel. Os escritores da Haskalá enriqueceram a língua com novas palavras e expressões e a aproximaram da modernidade. Foi o escritor Mêndele MocherSfórim que, ao utilizar um estílo eclético, ajudou a transformar o hebraico em idioma literário, retirando-o do pedestal de sacralidade em que se encontrou durante 1800 anos.
Pertencimento estético: colunas de jornal de Clarice Lispector
Authors: Von Wedemeyer Catarina 
Published: July 2021

Este artigo compara as colunas semanais que Clarice Lispector escreveu para o Jornal do Brasil entre 1967 e 1973. Estas colunas têm diferentes dimensões e abordam diversos tópicos. A autora nelas mistura diferentes características genéricas e cria um gênero próprio. Pode-se encontrar estruturas narrativas ou características típicas de ensaios filosóficos, combinadas com imagens poéticas, formulações míticas e alusões intertextuais. Ao dominar todas estas diferentes vozes, Lispector desenvolve uma forma artística que lhe permite “pertencer a si mesma”, como ela escreve numa de suas colunas. Este artigo sugere que estamos aqui lidando com algo mais: ao criar sua própria existência por meio do texto, e ao fazer da forma textual um assunto pessoal, Lispector está, ao mesmo tempo, escrevendo contra a ideologia da ditadura militar no Brasil, e respondendo a seu discurso monológico com uma vasta pluralidade de pensamentos.
“A Balada do Falso Messias” de Moacyr Scliar: Um Passeio pelos Porões do Judaísmo
Authors: Kirschbaum Saul 
Published: July 2021

Algumas obras de Moacyr Scliar poderiam, propriamente, ser agrupadas sob a denominação “passeios pelos porões do judaísmo”. São textos em que o autor revisita episódios da história judaica que não são motivos de orgulho para o povo judeu, trazendo-os para a atualidade em forma de paródia.
É o caso do conto “A Balada do Falso Messias”. Sua inspiração remonta ao fato histórico ocorrido na Palestina do século XVII protagonizado por Shabtai Zvi, proclamado Messias por seu “profeta” Natan de Gaza. Após empolgar comunidades judaicas de todo o mundo (inclusive Polônia e Holanda), Shabtai, colocado pelo sultão do Império Otomano ante à alternativa de decapitação, converteu-se ao Islã, para grande decepção de seus seguidores. Na verdade, um pequeno grupo destes manteve-se fiel, acreditando que a conversão fazia parte do plano de implementação da era messiânica.
Na versão de Scliar, Zvi e Natan, ainda vivos depois de mais de dois séculos, acompanham, em 1906, judeus russos a caminho das colônias agrícolas criadas pelo Barão Hirsch (que no conto passa a ser Barão Franck). A trajetória do “falso Messias” é recontada em meio a várias alusões a outros tantos episódios da história judaica e da vida de Jesus.
Ḥayyūdj, Revolução Gramatical do Hebraico e o سَاكِت لَتّن סַאכִּן לַיִّן Sākin Layyin “Repouso Frágil”
Authors: Faldini Fabio 
Published: July 2021

A noção de que o verbo hebraico é triliteral e formado pela intercalação de dois morfemas ‒ um consonantal, que lhe outorga o sentido abstrato, e outro transfixo, formado por vogais e consoantes que lhe definem o sentido concreto e materializado ‒ remonta à segunda metade do século X, ao sábio andaluz Abū Zakariyaʾ Yaḥya Ibn Dāwūd, de Fez (Marrocos), mais conhecido como Ḥayyūdj. Neste artigo, apresenta-se quem foi este grande sábio, as suas obras e de forma sucinta o conceito gramatical que sustenta a teoria da triliteralidade do verbo hebraico por ele desenvolvida: o سَاكِت لَتّن סַאכִּן לַיִّן sākin layyin “quiescente frágil”.
Elena Medel: “Hablo el idioma de las mujeres que me fueron”
Authors: Scarano Laura Rosana 
Published: July 2021

Elena Medel (Córdoba, 1985), escritora y directora de la editorial de poesía La Bella Varsovia, nos presenta una obra poética consistente y altamente provocativa. Proponemos aquí una breve travesía por algunos tópicos de su imaginario estético, que buscan situar su palabra en un horizonte histórico y generacional, pero recuperan a la vez sentidos contra un lenguaje demasiado complaciente con la sociedad de bienestar y la hegemonía globalizadora. Su poesía canaliza el malestar social sin recurrir a la denuncia estridente; da voz a la experiencia de ser mujer y persona, sin esencializar ninguna condición per se; cobija en la palabra un lugar para la intimidad sin olvidar que la alteridad la constituye. Funda “una raza de mujeres” que hablan sin eufemismos, entre los personajes de historieta y los ídolos adolescentes, admitiendo las lacerantes demandas del deseo y sus inocultables miserias.
Abstract 401: Experimental Aneurysm in Rats Excluded by Stent Graft: A New Model to Assess the Impact of Endovascular Aneurysm Repair on the Pathophysiology of Abdominal Aortic Aneurysm.
Authors: Rouer Martin , Rouer Martin , Alsac Jean-Marc , Michel Jean-Baptiste 
Published: July 2021

Introduction Biological study of the impact of endovascular aortic repair (EVAR) on pathophysiology of aortic abdominal aneurysms (AAA) can only be performed indirectly in humans, by imaging or search for peripheral biomarkers in the circulating blood. Therefore biological mechanism’s modifications into the aneurismal wall related to its endovascular exclusion are still to be elucidated, and small animal models should bring a valuable help in this field. We describe a new experimental model of stentgraft implantation for the exclusion of AAA in rats.
Methods Aneurysms were induced as previously described by intra-aortic elastase injection in Wistar rats, or by aortic decellularized xenograft transplantation in Lewis rats. At least 15 days later, the midline laparotomy was reopened, and 3mm covered stentgraft were inserted and deployed in the AAA to obtain its exclusion. The patency of the graft and the AAA exclusion could be assessed by a global arteriogram through the carotid artery. After closure of the laparotomy, the rats were awakened and returned to a normal diet.
Results This experimental model of AAA exclusion by a stentgraft allows many in vivo and ex vivo studies of the pathophysiology of AAA after EVAR. Histological modifications of the aortic wall and the intra-luminal thrombus could be assessed. The impact of EVAR on the adventitial immuno-inflammatory activity could be studied by different imaging such as MRI, scintigraphy or PET-scan. In situ biological and enzymatic activities could be evaluated to better understand the local mechanisms leading to AAA shrinkage or expansion after EVAR.
Conclusion Exclusion by stentgraft of experimental AAA in rats is the first described model of EVAR in small animals. It is feasible and reproducible for both elastase and xenograft experimental AAA models. This model will definitely help to a better analysis and understanding of the impact of stentgrafting on biological mechanisms in the aneurismal wall, that lead to EVAR success with shrinkage of aneurismal sac or EVAR failure with its continuing expansion.
Abstract 415: Oxidized High-Density Lipoprotein Reduces Blood Clot Firmness
Authors: Talens Simone , Leebeek Frank W , Rijken Dick C 
Published: July 2021

Low high-density lipoprotein (HDL) levels are a risk factor for cardiovascular disease. The best established anti-atherogenic property of HDL is its role in reverse cholesterol transport. Unlike HDL, low-density lipoprotein (LDL) has atherogenic properties and these are enhanced when LDL is oxidatively modified. Oxidized lipids can be transferred from oxidized LDL (oxLDL) to HDL and then be transported to the liver. However, other properties of circulating oxidized HDL (oxHDL) are not extensively investigated. Therefore we studied the role of native HDL (nHDL) and oxHDL in hemostasis. We collected citrated blood from healthy volunteers (n=5) and examined the effects of 4 mg/ml added nHDL and oxHDL on tissue factor-induced clot formation and clot firmness using thromboelastography (ROTEM). The effects of nLDL and oxLDL were measured as a control. Lipoproteins were isolated from plasma with density-gradient ultracentrifugation and oxidized with copper sulphate. The effect on fibrin degradation was examined by thromboelastography in the presence of cytochalasin D (2.5 μg/ml) and by measuring fibrin degradation products in the serum after thromboelastography using an ELISA. The ROTEM parameters clotting time, clot formation time and α-angle, were not affected by the addition of nHDL or oxHDL. The clot firmness, measured as amplitude, reduced during the thromboelastography by the addition of oxHDL. The amplitude (±SD) at 30 minutes, at 45 minutes, and at 60 minutes decreased from 100 (±0)%, 96 (±1.8)% and 91 (±2.9)% to 63 (±24.8)%, 51 (±24.3)% and 45 (±23.5)%, respectively (p<0.05) by the addition of oxHDL but did not change by the addition of nHDL. Fibrin breakdown, as measured by clot firmness in the presence of cytochalasin D was not affected by added oxHDL. In addition, the amount of fibrin degradation products after thromboelastography was comparable between control blood and blood with added oxHDL. No effects on clot firmness were observed with nLDL and oxLDL.
In conclusion, oxHDL, but not nHDL, reduces blood clot firmness in a time-dependent manner without interfering with the clot formation. This effect does not reflect fibrinolysis but most likely involves platelets. The precise mechanism by which oxHDL reduces clot firmness has yet to be elucidated.
Abstract 468: The Role of Ca2+/PKA Signaling Enhancer Protein Phosphatase Inhibitor 1 in the Control of Ca2+ Cycling and Signaling in VSMCs
Authors: Hadri Lahouaria , Bobe Regis , Lopez Jose J , Turnbull Irene C , Kovacic Jason C , Karakikes Ioannis , Kranias Evangelia , Hajjar Roger J , Larissa Lipskaia 
Published: July 2021

Vascular remodeling is associated with trans-differentiation of contractile vascular smooth muscle cells (VSMC) towards a proliferating/synthetic phenotype. We have recently demonstrated (Bobe et al., 2011) that the Ca2+ cycling in “contractile” VSMC requires the expression of the fast isoform of sarco/endo plasmic ATPase (SERCA2a), whereas the Ca2+ cycling in “proliferating” ones is associated with the expression of the ubiquitous isoform SERCA2b only. Phospholamban (PLB), a negative regulator of SERCA2 activity, is inhibited by PKA phosphorylation and activated by protein phosphatase 1 (PP1) dependent dephosphorylation. Inhibitor-1 (I-1), a highly specific inhibitor of PP1, enhances both PKA-dependent PLB phosphorylation and SERCA activity.
The goal of this study was to elucidate the role of PKA signaling enhancer I-1 in the control of VSMC Ca2+ cycling.
In humans and rodents, the expression of I-1 was found to be specific for contractile VSMC, whereas its target PP1 was highly expressed in synthetic VSMC. Consequently, PLB phosphorylation was decreased in synthetic VSMC whereas the expression of total PLB remained unchanged. Genetic deletion of I-1 in mice model (I-1 KO) resulted in lack of PLB phosphorylation in VSMC of adult animals. Despite the fact that SERCA2a was expressed, VSMCs from I-1 deficient mice were locked in the synthetic state. Consistent with this, the adult I-1 deficient mice developed a vascular proliferative disorder and excessive neointimal proliferation after vascular injury. Adenovirus-directed gene transfer of constitutively active I-1 (I-1c) significantly increased PLB phosphorylation and Ca2+ uptake in both synthetic and contractile VSMCs, however, there was no effect on the type of Ca2+ transient, which appears to be a SERCA2 isoform-dependent characteristic. Therefore, I-1c prevented proliferation and remodeling of contractile VSMC, but had no effect on synthetic VSMC, which predominantly express SERCA2b.
In conclusion, synergistic action of I-1 and SERCA2a is necessary for acquisition of the VSMC contractile phenotype. Gene transfer of I-1c may be considered as a promising therapeutic strategy for preventing vascular proliferative diseases.
Abstract 484: Acidic pH Triggers Secretion of Proinflammatory Cytokines in Human Macrophages
Authors: Rajamäki Kristiina , Nordström Tommy , öörni Katariina , Åkerman Karl E , Kovanen Petri T , Eklund Kari K 
Published: July 2021

Extracellular acidification can occur in atherosclerotic lesions, specifically in areas with high numbers of metabolically active macrophages secreting lactate and hydrogen ions. There is a growing body of evidence showing that acidification of the extracellular environment causes fundamental changes in the functions of immune cells.
Here we studied the effect of low pH on the secretion of proinflammatory cytokines by cultured human macrophages. Using custom manufactured cell culture media with neutral and acidic pH (pH 7.5-6.0) we discovered that acidic pH triggers secretion of interleukin(IL)-1beta and IL-18, but not of IL-1alpha. IL-1beta and IL-18 are both produced as proforms that are processed into the biologically active secreted form by the caspase-1 protease. The IL-1beta secretion induced by acidic pH was paralleled by caspase-1 activation, and inhibition of caspase-1 completely abolished IL-1beta secretion. Acidic pH-induced IL-1beta secretion was also abolished at high extracellular potassium concentrations, which implies that potassium efflux from cells is a crucial step upstream of caspase-1 activation. We are currently exploring the involvement of inflammasomes in the acidic pH -induced caspase-1 activation.
In conclusion, acidic microenvironments of atherosclerotic lesions may induce proinflammatory cytokine secretion in macrophages, so amplifying the progression of atherogenesis.
Abstract 493: Antiatherosclerotic Activity of a New P2y13 Receptor Agonist (ct1007900) in Animal Models
Authors: Barbaras Ronald , Baron Rudi , Goffinet Marine , Tardy Claudine , Boubekeur Nadia , Cholez Guy , Oniciu Daniela C , Lalwani Narendra D , Dasseux Jean-Louis H 
Published: July 2021

The F1-ATPase/P2Y13 receptor pathway has been involved in the regulation of the HDL uptake liver and disposition via the reverse cholesterol transport. CT1007900 is a novel selective P2Y13 receptor agonist that has been shown to enhance the HDL uptake that results in the increased secretion of the bile acid, bile cholesterol and bile phospholipid into the gallbladder in mice.

In the present study, CT1007900 has been evaluated in three different animal models of atherosclerosis. In ApoE
-/-
flow cessation model, the administration of the drug decreased the cholesterol concentration in atherosclerotic plaques. In a high fat diet fed ApoE
-/-
mouse model, the prevention of the progression of the plaque in aorta was further evaluated after 4-week treatment with CT1007900. The treated animals had significant decreases in plaque area, cholesterol content, VCAM1 expression and macrophage content.

In the high fat diet fed rabbits, 4-week treatment reduced the cholesterol content by about 30% and also decreased the thickness of the plaques. The ApoA1 mRNA levels in the liver and ApoA1 protein concentration in the plasma increased in the drug-treated animals. The HDL content of the treated animals showed a very consistent pattern with a specific decrease in large HDL and an increase of the “intermediate” size HDL particles as compared to control animals. These intermediate HDL particles seem to be more efficient particles for the removal of cholesterol from atherosclerotic plaques by increasing efflux of cholesterol from the macrophages present in the lesions. The plasma samples from drug treated rabbits showed a dose-dependent increase in the cholesterol efflux in an in vitro assay using J774 cells.
These results clearly demonstrate that improving functionality of HDL rather than the levels of HDL could have a positive impact on the atherosclerotic pathology. These data also support that P2Y13 receptor agonists could be useful pharmacological therapeutics for the treatment of complications due to atherosclerotic disease.