bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of clinical pharmacist led comprehensive medication management on diabetes care at Federally Qualified Health Centers within the BD Helping Build Healthy Communities program
Authors: Pastakia Sonak D. , Clark Alycia , Lewis Katie , Taugher Damon , Patel Rajal , Ali Liz , Wu Cecilia , Butler Racheal , Bateman M. Thomas , McCarthy Caitlin , Vargas Joanne , Poulsom Carrie 
Published: December 2021

AbstractIntroductionThe BD Helping Build Healthy Communities (HBHC) program is a philanthropically funded initiative designed to provide support for comprehensive medication management (CMM) services at Federally Qualified Health Centers (FQHCs) to support care for low‐income populations.ObjectivesThe primary outcome of interest was the change in glycosylated hemoglobin (HbA1c) between baseline and 6 months with changes in systolic (SBP) and diastolic blood pressure (DBP) between baseline and 6 months being evaluated as secondary outcomes.MethodsAwardees of the HBHC program who provided clinical pharmacist led CMM services in 2017, 2018, or 2019 to address the needs of people living with diabetes, were asked to complete a standardized monitoring template to evaluate their progress in serving patients receiving care at their clinic. The data from these reports was then analyzed using the paired t test to identify statistically significant changes in HbA1c, SBP, and DBP.ResultsA total of eight FQHCs, providing care to a total of 2502 patients, received funding within the HBHC program for their CMM activities related to diabetes. Within the primary outcome analysis of the change in HbA1c at 6 months, a statistically significant reduction in average clinic HbA1c between baseline and 6 months (9.4 vs 8.2, mean difference 1.2, 95% CI [0.45‐1.97, P <.01]) was observed. Similarly, a statistically significant reduction was observed between baseline and 6 months for SBP (140.8 vs 130.2 mm Hg, mean difference 10.5, 95% CI [2.2‐18.9 mm Hg, P <.05] and DBP (83.1 vs 78.9 mm Hg, mean difference 4.15, 95% CI [0.48‐7.82 mm Hg, P <.05]).ConclusionThe CMM activities within the HBHC program were able to demonstrate statistically significant reductions in HbA1c and blood pressure. Despite the inherent limitations associated with a retrospective analysis with diminishing patient follow‐up over 24 months, this analysis shows that investment in clinical pharmacist led CMM could potentially have positive impacts on clinical outcomes for patients receiving care at FQHCs. Additional rigorous studies are needed to confirm the findings seen in this analysis.
Clarification of cyanotoxins in El Guajaro Reservoir, Colombia using a microalgae‐based consortium MPMC
Authors: Gutiérrez Jaime E , Gutiérrez‐Hoyos Nohora , Gutiérrez Benedetti Juan S , Vives Martha J , Sivasubramanian V 
Published: December 2021

AbstractBACKGROUNDCyanobacteria blooms occur in freshwater and saline ecosystems under certain environmental conditions, such as eutrophication, that are often accompanied by the production of cyanotoxins; Those biological toxins are a risk to the health of animals and humans. The eutrophication of water bodies is becoming more frequent due to organic pollution pressure from swage discharge, so outcrops are frequent and difficult to manage by the communities affected by these phenomena. Most of the control mechanisms for these events are carried out through nutrient input constraints, sonication, and (more recently) biological control.RESULTSIn this work, a cyanobacterial bloom in a reservoir in a tropical zone of northern Colombia was characterized. The microbiological dominance ofMicrocystissp. and the presence of microcystin in the water were documented. A bioaugmentation process was then tested with a microbial consortium containing a predominance of microalgae (MCPM); after this, the dominance of cyanobacteria was broken and the richness and density of the phytoplankton were recovered. The decrease in cyanobacterial density was documented 15 days after the MCPM bioaugmentation began. A significant removal (34% to 53%) ofMicrocystissp, was observed between days 1 and 16; from day 16 to day 58, removal ofMicrocysissp reached 92% to 100%. The bioaugmentation took a total of 58 days.CONCLUSIONThis work raises the possibility of using the competitive inhibition capacity of nonharmful microalgae on cyanobacteria as an ecological tool to counteract blooms and mitigate the risk of cyanotoxins for animals and humans. © 2021 Society of Chemical Industry (SCI).
Combined ultrasound and fluoroscopy guided tunneled external lumbar drain placement in children
Authors: Bertino Frederic , Shin David S. , Weaver John J. , Jeyakumar Arthie , Chick Jeffrey Forris Beecham , Woods Michael A. , Monroe Eric J. 
Published: December 2021

AbstractExternal lumbar drain placement has been shown to be an efficacious and safe approach to managing various forms of intracranial hypertension in adult patients and children. The use of ultrasound guidance for lumbar punctures in young patients has been described however, but the modality is not routinely used for the placement of tunneled lumbar drains. In this report, two cases are presented that detail experience using ultrasound guidance for tunneled lumbar drains in children.
Leg‐type form of idiopathic multicentric Castleman disease associated with severe lower extremity chronic venous/lymphatic disease
Authors: Ballul Thomas , Belfeki Nabil , de Masson Adèle , Meignin Véronique , Woerther Paul‐Louis , Martin Antoine , Poullot Elsa , Wargnier Alain , Fadlallah Jehane , Garzaro Margaux , Malphettes Marion , Fieschi Claire , Maisonobe Lucas , Bensekhri Hayat , Guillot Hélène , Bertinchamp Rémi , Jachiet Marie , Poirot Justine , Galicier Lionel , Oksenhendler Eric , Boutboul David 
Published: December 2021

AbstractIdiopathic multicentric Castleman disease (iMCD) is a lymphoproliferative disease of unknown etiology. Deciphering mechanisms involved in CD pathogenesis may help improving patients’ care. Six cases of stereotyped sub‐diaphragmatic iMCD affecting lower limb‐draining areas and associated with severe and often ulcerative lower extremity chronic dermatological condition were identified in our cohort. Pathological examination revealed mixed or plasma‐cell type MCD. In three patients, shotgun metagenomics failed to identify any pathogen in involved lymph nodes. Antibiotics had a suspensive effect while rituximab and tocilizumab failed to improve the condition. This novel entity requires a specific approach and exclusion of potentially harmful immunomodulation.
Advances in the synthesis of α,α‐difluoro‐γ‐lactams
Authors: Zhang Cai , Liu Yunyun 
Published: December 2021

AbstractThe γ‐lactam rings have been found to be the core structures of a large number of natural compounds and drugs with a wide range of biological activities. This mini‐review focuses on the synthesis of α,α‐difluoro‐γ‐lactams using α‐bromodifluoroacetamides, α‐bromodifluoroacetates, 2‐alkyl‐2,2‐difluoroacetamides, etc. as fluorine sources.
Development of a highly efficient in‐tube solid‐phase microextraction system coupled with UHPLC‐MS/MS for analyzing trace hydroxyl polycyclic aromatic hydrocarbons in biological samples
Authors: Zhang Qianchun , Zhang Xiaolan , Yang Bingnian , Liu Shan , Wen Ming , Bao Linchun , Jiang Li 
Published: December 2021

AbstractHydroxyl polycyclic aromatic hydrocarbons are considered active mutagenic and carcinogenic substances and are found in extremely low levels (ng/g) in biological samples. As a result, their determination in urine and blood samples is challenging, and a sensitive and effective method for the analysis of trace hydroxyl polycyclic aromatic hydrocarbons in complex biological matrices is required. In this work, a novel macroporous in‐tube solid‐phase microextraction monolith was prepared via a thiol‐yne click reaction, and a highly efficient analytical method based on in‐tube solid‐phase microextraction coupled with UHPLC‐MS/MS was developed to determine hydroxyl polycyclic aromatic hydrocarbons with low detection limits of 0.137–11.0 ng/L in complex biological samples. Four hydroxyl polycyclic aromatic hydrocarbons, namely, 2‐hydroxyanthraquinone, 1‐hydroxypyrene, 1,8‐dihydroxyanthraquinone, and 6‐hydroxychrysene, were determined in the urine samples of smokers, non‐smokers, and whole blood samples of mice. Satisfactory recoveries were achieved in the range of 83.1–113% with relative standard deviations of 3.2–9.7%. It was found that implementation of the macroporous monolith gave a highly efficient approach for enriching trace hydroxyl polycyclic aromatic hydrocarbons in biological samples.
The multifaceted roles of mass spectrometric analysis in nucleic acids drug discovery and development
Authors: Kenderdine Thomas , Fabris Dan 
Published: December 2021

AbstractThe deceptively simple concepts of mass determination and fragment analysis are the basis for the application of mass spectrometry (MS) to a boundless range of analytes, including fundamental components and polymeric forms of nucleic acids (NAs). This platform affords the intrinsic ability to observe first‐hand the effects of NA‐active drugs on the chemical structure, composition, and conformation of their targets, which might affect their ability to interact with cognate NAs, proteins, and other biomolecules present in a natural environment. The possibility of interfacing with high‐performance separation techniques represents a multiplying factor that extends these capabilities to cover complex sample mixtures obtained from organisms that were exposed to NA‐active drugs. This report provides a brief overview of these capabilities in the context of the analysis of the products of NA‐drug activity and NA therapeutics. The selected examples offer proof‐of‐principle of the applicability of this platform to all phases of the journey undertaken by any successful NA drug from laboratory to bedside, and provide the rationale for its rapid expansion outside traditional laboratory settings in support to ever growing manufacturing operations.
Synthesis, Characterization and Hyperthermic Evaluation of PEGylated Superparamagnetic MnFe2O4 Ferrite Nanoparticles for Cancer Therapeutics Applications
Authors: Kharat Prashant B. , Somvanshi Sandeep B. , Somwanshi Saurabh B. , Mopari Anuja M. 
Published: December 2021

AbstractPoly(ethylene glycol) (PEG)‐coated superparamagnetic MnFe2O4 ferrite nanoparticles are of great interest for application in magnetic fluid hyperthermia (MFH) due to their heat generation capability in an external alternating magnetic field, besides biocompatibility, and surface properties. MFH has emerged as a promising therapeutic approach for cancer treatment and is based on controlled heating tumor tissue through the accumulation of MnFe2O4 ferrite nanoparticles within cancer cells. In the present work, MnFe2O4 superparamagnetic ferrite nanoparticles via the chemical combustion method are synthesized. The preparation of PEGylated MnFe2O4 ferrite nanoparticles, which involves the attachment of such molecules at the surface, without the need for coupling agents or prior modification on the species involved. The conjugation of folate onto MnFe2O4 ferrite nanoparticles is confirmed by FTIR spectroscopy. The MnFe2O4 ferrite nanoparticles are colloidal stable. The obtained targeted PEGylated MnFe2O4 ferrite nanoparticles show superparamagnetic behavior with a saturation magnetization of 78.68 emu·g−1 at 300 K. Their specific absorption rate (SAR) ranged from 43.2 to 19.5 W g−1 in an alternating magnetic field of 5—20 kA m−1. The heat generated is sufficient to raise the sample temperature to the therapeutic range used in MFH establishing this system as promising candidates for use in MFH treatment.
The FoxQ1 transcription factor is a novel regulator of electron transport chain complex I subunits in human breast cancer cells
Authors: Kim Su‐Hyeong , Singh Shivendra V. 
Published: December 2021

AbstractThe FoxQ1 is an oncogenic transcription factor that is overexpressed in basal‐like and luminal‐type human breast cancers when compared to the normal mammary tissue. The FoxQ1 is implicated in mammary tumor progression. However, the mechanism by which FoxQ1 promotes mammary tumorigenesis is not fully understood. In this study, we present experimental evidence for a novel function of FoxQ1 in the regulation of complex I activity of the electron transport chain. The RNA‐seq data from FoxQ1 overexpressing basal‐like SUM159 cells revealed a statistically significant increase in the expression of complex I subunits NDUFS1 and NDUFS2 when compared to the empty vector (EV) transfected control cells. Consistent with these results, the basal and ATP‐linked oxygen consumption rates were significantly increased by FoxQ1 overexpression in SUM159 and luminal‐type MCF‐7 cells. The FoxQ1 overexpression in both cell lines resulted in increased intracellular levels of pyruvate, lactate, and ATP that was associated with overexpression of pyruvate dehydrogenase and pyruvate carboxylase proteins. Activity and assembly of complex I were significantly enhanced by FoxQ1 overexpression in SUM159 and MCF‐7 cells that correlated with increased mRNA and/or protein levels of complex I subunits NDUFS1, NDUFS2, NDUFV1, and NDUFV2. The chromatin immunoprecipitation assay revealed the recruitment of FoxQ1 at the promoters of both NDUFS1 and NDUFV1. The cell proliferation of SUM159 and MCF‐7 cells was increased significantly by overexpression of NDUFS1 as well as NDUFV1 proteins. In conclusion, we propose that increased complex I‐linked oxidative phosphorylation is partly responsible for oncogenic role of FoxQ1 at least in human breast cancer cells.
Exploring the inclusion of beneficiary voices in international development fundraising campaign creation
Authors: Ninaber Victoria , Mittelman Robert 
Published: December 2021

AbstractCharitable fundraising appeals for international development created for potential donors in the Global North are often, if not always, designed without the inclusion of voices and insights from the intended beneficiaries in the Global South. The implications of these appeals, void of beneficiary input, may serve to proliferate poverty porn and racial stereotypes, promote paternalistic and colonial thinking, and strengthen white savior syndrome. This exploratory paper, through a set of interviews and a focus group with fundraising professionals at international development organizations, examines the need for a beneficiary‐centered Code of Ethics. A framework, based on the four major findings, is proposed that begins with beneficiary input and considerations offer charities an inclusive method for the design of future fundraising appeals and a way to fulfill their responsibility in how the beneficiary is depicted and the societal understanding of their situation.
Preparation and properties of bifunctional associative polymer with twin tail and long chain structure for shale gas fracturing
Authors: Zhou Cheng yu , Lei Ming yao , Zhou Min , Zeng Ling hao , Sun Yuan , Huang Qiang , Xiao Ying , Zhang Peng 
Published: December 2021

AbstractCompared with conventional fracturing, shale reservoir fracturing has the characteristics of 1000 tons of sand and 10,000 cubic meters of liquid. The concentrated reflection of the fracturing fluid is low friction and strong carrier which are required. A novel bifunctional associative polymer was synthesized by free radical micellar polymerization with twin tails and long chain hydrophobic monomers. The structures and characteristics of the polymer were confirmed by Fourier transform infrared spectroscopy, 1H NMR spectroscopy, DSC, SEM and AFM. Sand‐carrying of the fracturing fluid experiments shows when the quartz sand has a particle size of 0.3 and 0.6 mm, the sedimentation velocities are about 0.12 and 0.40 cm min−1, respectively. The drag reduction experimental results show that when the flow rate rises to 55 L·min−1, drag reduction rate can reach 68.1%. The polymer polyacrylamide has good shear performance, but the permeability damage rate is up to 16.10%.
A novel and unique ATP hydrolysis to AMP by a human Hsp70 Binding immunoglobin protein (BiP)
Authors: Li Hongtao , Musayev Faik N. , Yang Jiao , Su Jiayue , Liu Qingdai , Wang Wei , Fang Xianjun , Zhou Lei , Liu Qinglian 
Published: December 2021

AbstractHsp70s are ubiquitous and highly conserved molecular chaperones. They play crucial roles in maintaining cellular protein homeostasis. It is well established that Hsp70s use the energy of ATP hydrolysis to ADP to power the chaperone activity regardless of the cellular locations and isoforms. Binding immunoglobin protein (BiP), the major member of Hsp70s in the endoplasmic reticulum, is essential for protein folding and quality control. Unexpectedly, our structural analysis of BiP demonstrated a novel ATP hydrolysis to AMP during crystallization under the acidic conditions. Our biochemical studies confirmed this newly discovered ATP to AMP hydrolysis in solutions. Unlike the canonical ATP to ADP hydrolysis observed for Hsp70s, this ATP hydrolysis to AMP depends on the substrate‐binding domain of BiP and is inhibited by the binding of a peptide substrate. Intriguingly, this ATP to AMP hydrolysis is unique to BiP, not shared by two representative Hsp70 proteins from the cytosol. Taken together, this novel and unique ATP to AMP hydrolysis may provide a potentially new direction for understanding the activity and cellular function of BiP.
The efficacy of Jujube syrup on the prevention of drug‐induced hepatotoxicity in pulmonary tuberculosis patients: A pilot randomized double‐blind placebo‐controlled clinical trial
Authors: Maddahi Seyedeh Zahra , Jokar Assie , Kamalinejad Mohammad , Behnampur Nasser 
Published: December 2021

AbstractLiver injury is the most common complication of anti‐tuberculosis drugs that can cause significant problems. The study aimed to determine the effectiveness of Jujube syrup on the prevention of antituberculosis drug‐induced hepatotoxicity (DIH). This pilot randomized double‐blind study was conducted based on a placebo‐controlled design in patients with tuberculosis (TB). The patients were divided into two groups based on the block random allocation method and received 10 cc of jujube or placebo syrup per day. The liver enzyme levels were assessed as primary outcomes, and the severity of cough, anorexia, and nausea along with the quality of life (QOL) was assessed as secondary outcomes. Finally, eight and nine patients in the jujube and placebo groups completed the study, respectively. In the second week of the study, 27.3% of the patients in the placebo group developed hepatotoxicity. Moreover, there was no liver toxicity in the jujube group. This difference between the two groups was statistically significant (p = .037). Furthermore, the severity of cough in patients in the jujube group decreased significantly during weeks 2 and 4. The QOL significantly improved in the jujube group, compared to the placebo group. This study suggested that Jujube syrup could prevent anti‐TB DIH. It can also improve the severity of cough and the QOL in pulmonary TB patients.
Multiplex SNP Genotyping Using SWITCH: Sequence‐Specific Nanoparticle with Interpretative Toehold‐Mediated Sequence Decoding in Hydrogel
Authors: Choi Woongsun , Park Eunhye , Bae Seojin , Choi Kyung‐Hak , Han Sangeun , Son Kuk‐Hui , Lee Do Young , Cho Il‐Joo , Seong Hyejeong , Hwang Kyo Seon , Nam Jwa‐Min , Choi Jungkyu , Lee Hyojin , Choi Nakwon 
Published: December 2021

AbstractSingle nucleotide polymorphisms (SNPs) that can alter phenotypes of individuals play a pivotal role in disease development and, more importantly, responses to therapy. However, SNP genotyping has been challenging due to the similarity of SNP alleles and their low concentration in biological samples. Sequence‐specific nanoparticle with interpretative toehold‐mediated sequence decoding in hydrogel (SWITCH) for multiplex SNP genotyping is presented. The encoding with gold nanoparticle probes transduces each SNP target to ≈1000 invaders with prominently different sequences between wild and mutant types, featuring polymerase chain reaction (PCR)‐free amplification. Subsequently, the toehold‐mediated DNA replacement in hydrogel microparticles decodes the invaders via SNP‐specific fluorescence signals. The 4‐plex detection of the warfarin‐associated SNP targets spiked in commercially validated human serum (S1‐100ML, Merck) is successfully demonstrated with excellent specificity. This work is the first technology development presenting PCR‐free, multiplex SNP genotyping with a single reporting fluorophore, to the best of knowledge.
Recent progress and future perspectives of flexible metal‐air batteries
Authors: Li Tingzhen , Peng Xinwen , Cui Peng , Shi Ge , Yang Wu , Chen Zehong , Huang Yongfa , Chen Yongkang , Peng Jinyuan , Zou Ren , Zeng Xiaoyan , Yu Jian , Gan Jianyun , Mu Zhiyuan , Chen Yuling , Zeng Jiaming , Liu Juan , Yang Yunyi , Wei Yujia , Lu Jun 
Published: December 2021

AbstractWith the rapid development of wearable and intelligent flexible electronic devices (FEDs), the demand for flexible energy storage/conversion devices (ESCDs) has also increased. Rechargeable flexible metal‐air batteries (MABs) are expected to be one of the most ideal ESCDs due to their high theoretical energy density, cost advantage, and strong deformation adaptability. With the improvement of the device design, material assemblies, and manufacturing technology, the research on the electrochemical performance of flexible MABs has made significant progress. However, achieving the high mechanical flexibility, high safety, and wearable comfortability required by FEDs while maintaining the high performance of flexible MABs are still a daunting challenge. In this review, flexible Zn‐air and Li‐air batteries are mainly exemplified to describe the most recent progress and challenges of flexible MABs. We start with an overview of the structure and configuration of the flexible MABs and discuss their impact on battery performance and function. Then it focuses on the research progress of flexible metal anodes, gel polymer electrolytes, and air cathodes. Finally, the main challenges and future research perspectives involving flexible MABs for FEDs are proposed.
Interleukin 10 and transforming growth factor‐beta 1 plasma levels in atopic dogs before and during immunotherapy
Authors: Martini Franco , Rostaher Ana , Favrot Claude , Fischer Nina 
Published: December 2021

AbstractBackgroundHuman studies suggest that the cytokines, interleukin 10 (IL‐10) and transforming growth factor‐beta 1 (TGF‐ß1) may play an important role in allergen‐specific immunotherapy (ASIT). However, there is little known about the function of these cytokines in atopic dogs. This study compared the plasma levels of IL‐10 and TGF‐ß1 in atopic and control dogs and investigated their changes during different ASIT approaches.MethodsA total of 54 atopic and 32 control dogs were included. Immunotherapy was performed in 30 atopic dogs. The dogs undergoing immunotherapy were allocated to four groups of different ASIT approaches (namely subcutaneous, intralymphatic, sublingual ASIT and subcutaneous ASIT with recombinant allergens). Blood samples were collected at four timepoints throughout the one year of ASIT. Canine atopic dermatitis extent and severity index, pruritus visual analogue scale and medication score were recorded at each timepoint. Commercially available ELISA kits were used to quantify IL‐10 and TGF‐ß1 in plasma.ResultsThere was no significant difference in IL‐10 and TGF‐ß1 between atopic and control dogs. The IL‐10 levels were significantly increased in the intralymphatic group at the end of the study. No significant differences were found in the other groups for both IL‐10 and TGF‐ß1.ConclusionThe findings of this work suggest that IL‐10 and TGF‐ß1 cannot be used to monitor the course of the disease during ASIT.