bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancement of light aircraft 6 DOF simulation using flight test data in longitudinal motion
Authors: Nguyen L.V.T. , Tyan M. , Lee J.-W. , Kim S. 
Published: April 2021

Abstract
This paper proposes a procedure to improve the accuracy of the light aircraft 6 DOF simulation model by implementing model tuning and aerodynamic database correction using flight test data. In this study, the full-scale flight testing of a 2-seater aircraft has been performed in specific longitudinal manoeuver for model enhancement and simulation validation purposes. The baseline simulation model database is constructed using multi-fidelity analysis methods such as wind tunnel (W/T) test, computational fluid dynamic (CFD) and empirical calculation. The enhancement process starts with identifying longitudinal equations of motion for sensitivity analysis, where the effect of crucial parameters is analysed and then adjusted using the model tuning technique. Next, the classical Maximum Likelihood (ML) estimation method is applied to calculate aerodynamic derivatives from flight test data, these parameters are utilised to correct the initial aerodynamic table. A simulation validation process is introduced to evaluate the accuracy of the enhanced 6 DOF simulation model. The presented results demonstrate that the applied enhancement procedure has improved the simulation accuracy in longitudinal motion. The discrepancy between the simulation and flight test response showed significant improvement, which satisfies the regulation tolerance.
Law and Development Minus Legal Transplants: The Example of China in Vietnam
Authors: Erie Matthew S. , Hai Ha Do 
Published: April 2021

AbstractLegal transplants are broadly recognized as one of the main mechanisms by which donor states influence the legal development of recipient states. The experience of China, however, challenges convention. While, in recent years, China has been one of the largest capital-exporting countries in the world and has mobilized law to protect its investment in high-risk recipient states, legal transplants have, to date, not played a major role in China’s approach to law and development. This article examines this puzzle through the case of China’s participation in formulating Vietnam’s 2018 SEZ Bill. In doing so, this article sets forth a number of hypotheses as to why Chinese law has thus far not assumed the form of legal transplant. The example of the SEZ Bill demonstrates how Chinese legal transplants depend as much on the “pull” of recipient states as they do on the “push” of the donor. The case-study of the SEZ Bill raises important questions not only for Chinese law and development, but also, more generally, for the viability of “second-order” legal transplants: those from an Asian donor to an Asian recipient.
Impact of the COVID-19 pandemic on patients with pre-existing mood disorders
Authors: McLoughlin James , O’Grady Margaret M. , Hallahan Brian 
Published: April 2021

AbstractObjectives:To examine the psychological and social impact of the COVID-19 pandemic on patients with established mood disorders during a period of stringent mandated social restrictions.Methods:Semi-structured interviews were conducted with 36 individuals attending the Galway–Roscommon Mental Health Services with an International Statistical Classification of Diseases and Related Health Problems, tenth revision (ICD-10) diagnosis of either Bipolar Affective Disorder (BPAD) (n = 20) or Emotionally Unstable Personality Disorder (EUPD) (n = 16) in this cross-sectional study. We determined the impact of the COVID-19 restrictions on anxiety and depressive symptoms, impulsivity, thoughts of self-harm, social and occupational functioning and quality of life.Results:The COVID-19 pandemic deleteriously impacted mental health (56.3% v. 15.0%, χ2 = 7.42, p = 0.02), and mood (75.0% v. 20.0%, χ2 = 11.17, p = 0.002) to a greater extent in the EUPD compared to the bipolar disorder cohort, with 43.8% of individuals with EUPD reporting an increase in suicidal ideation. Psychometric rating scales [Beck Anxiety Inventory (BAI), Beck Depression Scale (BDS), Beck Hopelessness Scale (BHS), Barratt Impulsivity Scale (BIS)] and Likert scales for anxiety, mood and quality of life noted significantly higher levels of psychopathology in the EUPD cohort (p < 0.01). Qualitative analysis reflected quantitative data with themes of the employment of maladaptive coping mechanisms and reduced mental health supports notable.Conclusions:Individuals with EUPD are experiencing significant mental health difficulties related to the COVID-19 pandemic. The provision and recommencement of therapeutic interventions to this cohort, in particular, are warranted given the significant distress and symptoms being experienced.
Concealing Conflict Markets: How Rebels and Firms Use State Institutions to Launder Wartime Trade
Authors: Sweet Rachel 
Published: April 2021

AbstractAlthough rebel groups are players on the international stage, little is known about their financial strategies at this scale. Existing research suggests that rebels succeed in cross-border trade by using informal networks that evade state authority. Yet rebels face a critical challenge: they operate in a normative environment that values state recognition and penalizes their illegitimate status. New evidence reveals that rebels can overcome this barrier and better connect to global economies not by evading the state but by infiltrating its institutions. Drawing on unprecedented data—the internal records of armed groups and their trading partners—I examine how rebels use state agencies in conflict zones to manufacture a legal cover for wartime trade. By using state agencies to provide false certification, rebels can place the stamp of state on their trade deals. This strategy of legal appropriation is a fundamentally different model of how conflict markets skirt sanctions and connect to global buyers. I develop a framework for how this strategy works that traces how international sovereignty norms and sanctions regimes create incentives for rebels, firms, and bureaucrats to coordinate around this legal veneer across the supply chain. The framework and evidence contribute theoretical and policy understandings for rebel governance, state building and fragmentation, and illicit global markets.
Variations in funding for treatment of obstructive sleep apnoea in England
Authors: Chaidas K , Ashman A 
Published: April 2021

AbstractObjectivesThis study aimed to review the funding policies of clinical commissioning groups for treatment of obstructive sleep apnoea in England.MethodsPublished policies from a randomly selected sample of 60 out of 190 clinical commissioning groups were reviewed.ResultsContinuous positive airway pressure was funded based on a clinical assessment or according to criteria that were in line with national guidelines in most clinical commissioning groups (49 of 60), with 11 clinical commissioning groups offering no policy. Mandibular advancement devices, tonsillectomy and nasal surgery were funded based on a clinical assessment or certain criteria in 16, 25 and 16 clinical commissioning groups, respectively. In contrast, only one clinical commissioning group provided funding for soft palate, tongue base or mandibular surgery. Hypoglossal nerve stimulation was not mentioned in any clinical commissioning group's policy.ConclusionAlthough most clinical commissioning groups provide funding for the use of continuous positive airway pressure, the availability of funding for other obstructive sleep apnoea treatment modalities is heterogeneous, leaving continuous positive airway pressure intolerant patients with limited therapeutic options in some regions.
The Ties That Bind: Life Care Contracts and Nursing Homes
Authors: Leonard Lawrence R. 
Published: April 2021

AbstractApproximately 1.3 million of our nation's elderly live in nursing homes. Despite the increasingly important role of Medicare and Medicaid, many must bear the costs of their care. This Note examines one means of financing nursing home care—the life care contract. These require residents to pay an entrance fee and transfer to the nursing home all or part of their property in return for the home's promise to provide care for the remainder of the resident's life. The Note discusses the potential problems a life care resident may face, such as substandard living conditions or a home's financial instability. It concludes by delineating steps that potential residents can take in constructing life care contracts to ensure protection of their rights and needs.
Controlling Post-transfusion Hepatitis: A Proposal to Publicize Hepatitis Rates of Transfusion Facilities
Authors: Finkelstein Stan N. , Sapolsky Harvey M. 
Published: April 2021

AbstractA federal requirement that donor blood be labelled as either “paid” or “volunteer” took effect on May 15, 1978. A major rationale for requiring such labelling is that physicians, now that they can distinguish between categories of blood, will fear liability for post-transfusion hepatitis resulting from the use of paid blood. Thus, supporters of the labelling requirement hope that it will deter the use of high-risk commercial blood. Some paid blood, however, is not commercial blood and in fact may be safer than volunteer blood. The labelling strategy for hepatitis control, therefore, has negative as well as positive attributes. This Article considers the efficacy of blood labelling as a hepatitis control measure and proposes an alternative strategy—the periodic publicizing of hepatitis rates of facilities that perform transfusions—that, if practiced responsibly, could significantly decrease hepatitis transmission rates.
Imaging radar for automated driving functions
Authors: Iqbal Hasan , Löffler Andreas , Mejdoub Mohamed Nour , Zimmermann Daniel , Gruson Frank 
Published: April 2021

AbstractThis work presents the implementation of a synthetic aperture radar (SAR) at 77 GHz, for automotive applications. This implementation is unique in the sense that it is a radar-only solution for most use-cases. The set-up consists of two radar sensors, one to calculate the ego trajectory and the second for SAR measurements. Thus the need for expensive GNSS-based dead reckoning systems, which are in any case not accurate enough to fulfill the requirements for SAR, is eliminated. The results presented here have been obtained from a SAR implementation which is able to deliver processed images in a matter of seconds from the point where the targets were measured. This has been accomplished using radar sensors which will be commercially available in the near future. Hence the results are easily reproducible since the deployed radars are not special research prototypes. The successful widespread use of SAR in the automotive industry will be a large step forward toward developing automated parking functions which will be far superior to today's systems based on ultrasound sensors and radar (short range) beam-forming algorithms. The same short-range radar can be used for SAR, and the ultrasound sensors can thus be completely omitted from the vehicle.
Assessing the Impacts of Recent Crop Expansion on Water Quality in the Missouri River Basin Using the Soil and Water Assessment Tool
Authors: Chen Pan , Yuan Yongping , Li Wenhong , LeDuc Stephen D. , Lark Tyler J. , Zhang Xuesong , Clark Christopher 
Published: April 2021

AbstractThe Missouri River Basin (MORB) has experienced a resurgence of grassland conversion to crop production, which raised concerns on water quality. We applied the Soil and Water Assessment Tool (SWAT) to address how this conversion would impact water quality. We designed three crop production scenarios representing conversion of grassland to: (a) continuous corn; (b) corn/soybean rotation; and (c) corn/wheat rotation to assess the impact. The SWAT model results showed: (a) the lower MORB produced high total nitrogen (TN) and total phosphorus (TP) load before conversion (baseline) due mainly to high precipitation and high agricultural activity; (b) the greatest percentage increases of TN and TP occurred in the North and South Dakotas, coinciding with the highest amount of grassland conversion to cropland; and (c) grassland conversion to continuous corn resulted in the greatest increase in TN and TP loads, followed by conversion to corn/soybean and then conversion to corn/wheat. Although the greatest percentage increases of TN and TP occurred in the North and South Dakotas, these areas still contributed relatively low TN and TP to total basin loads after conversion. However, watersheds, predominantly in the lower MORB continued to be “hotspots” that contributed the greatest amounts of TN and TP to the total basin loads—driven by a combination of grassland conversion, high precipitation, and loading from pre‐existing cropland. At the watershed outlet, the TN and TP loads were increased by 6.4% (13,800 t/yr) and 8.7% (3,400 t/yr), respectively, during the 2008–2016 period for the conversion to continuous corn scenario.
A Comparison of Six Transport Models of the MADE‐1 Experiment Implemented With Different Types of Hydraulic Data
Authors: Zech Alraune , Attinger Sabine , Bellin Alberto , Cvetkovic Vladimir , Dagan Gedeon , Dentz Marco , Dietrich Peter , Fiori Aldo , Teutsch Georg 
Published: April 2021

AbstractSix conceptually different transport models were applied to the macrodispersion experiment (MADE)‐1 field tracer experiment as a first major attempt for model comparison. The objective was to show that complex mass distributions in heterogeneous aquifers can be predicted without calibration of transport parameters, solely making use of structural and flow data. The models differ in their conceptualization of the heterogeneous aquifer structure, computational complexity, and use of conductivity data obtained from various observation methods (direct push injection logging, DPIL, grain size analysis, pumping tests and flowmeter). They share the same underlying physical transport process of advection by the velocity field solely. Predictive capability is assessed by comparing results to observed longitudinal mass distributions of the MADE‐1 experiment. The decreasing mass recovery of the observed plume is attributed to sampling and no physical process like mass transfer is invoked by the models. Measures like peak location and strength are used in comparing the modeled and measured plume mass distribution. Comparison of models reveals that the predictions of the solute plume agree reasonably well with observations, if the models are underlain by a few parameters of close values: mean velocity, a parameter reflecting log‐conductivity variability, and a horizontal length scale related to conductivity spatial correlation. The robustness of the results implies that conservative transport models with appropriate conductivity upscaling strategies of various observation data provide reasonable predictions of plumes longitudinal mass distribution, as long as key features are taken into account.
HMGA1B/2 transcriptionally activated-POU1F1 facilitates gastric carcinoma metastasis via CXCL12/CXCR4 axis-mediated macrophage polarization
Authors: Tang Cheng , Lei Xiong , Xiong Lingqiang , Hu Zhigao , Tang Bo 
Published: April 2021

AbstractTumor-associated macrophages (TAMs) in the tumor microenvironment contribute to poor prognosis in gastric cancer (GC). However, the underlying mechanism by which TAMs promote GC progression and metastasis remains elusive. Expression of POU1F1 was detected in 60 matched GC-normal tissue pairs using qRT-PCR and immunohistochemistry (IHC) analysis. The correlation between POU1F1 and the clinical-pathological factors of GC patients were further assessed. Cell proliferation was monitored by CCK-8, colony formation, and 5-Ethynyl-2’-deoxyuridine (EdU) incorporation assays. Cell migration and invasion were assessed by transwell assays. The impact on angiogenesis was evaluated by tube formation assay. Xenograft model was generated to investigate the role of POU1F1 on tumor growth and lung metastasis in vivo. GST pull-down and Co-immunoprecipitation (Co-IP) were used to study the interaction between HMGA1B/2 and POU1F1. Chromatin immunoprecipitation (ChIP) and dual luciferase reporter assays were performed to investigate the transcriptional regulation of POU1F1. Flow cytometry was performed to detect the surface expression of macrophage markers. Upregulated POU1F1 observed both in GC tissues and cell lines was positively correlated with poor prognosis. Knockdown of POU1F1 inhibited cell proliferation, migration, invasion, and angiogenesis in vitro, and suppressed tumor growth in vivo. HMGA1B/2 transcriptionally activated-POU1F1. POU1F1 promoted GC progression via regulating macrophage proliferation, migration, polarization, and angiogenesis in a CXCL12/CXCR4-dependent manner. POU1F1 also promoted GC metastasis in lung by modulating macrophage polarization through CXCL12/CXCR4 axis in vivo. HMGA1B/2-upregulated POU1F1 promoted GC metastasis via regulating macrophage polarization in a CXCL12/CXCR4-dependent manner.
Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma
Authors: Rexha Irvin , Laage-Gaupp Fabian , Chapiro Julius , Miszczuk Milena Anna , van Breugel Johanna Maria Mijntje , Lin MingDe , Konstantinidis Menelaos , Duran Rafael , Gebauer Bernhard , Georgiades Christos , Hong Kelvin , Nezami Nariman 
Published: April 2021

AbstractThis study was designed to assess 3D vs. 1D and 2D quantitative tumor analysis for prediction of overall survival (OS) in patients with Intrahepatic Cholangiocarcinoma (ICC) who underwent conventional transarterial chemoembolization (cTACE). 73 ICC patients who underwent cTACE were included in this retrospective analysis between Oct 2001 and Feb 2015. The overall and enhancing tumor diameters and the maximum cross-sectional and enhancing tumor areas were measured on baseline images. 3D quantitative tumor analysis was used to assess total tumor volume (TTV), enhancing tumor volume (ETV), and enhancing tumor burden (ETB) (ratio between ETV and liver volume). Patients were divided into low (LTB) and high tumor burden (HTB) groups. There was a significant separation between survival curves of the LTB and HTB groups using enhancing tumor diameter (p = 0.003), enhancing tumor area (p = 0.03), TTV (p = 0.03), and ETV (p = 0.01). Multivariate analysis showed a hazard ratio of 0.46 (95%CI: 0.27–0.78, p = 0.004) for enhancing tumor diameter, 0.56 (95% CI 0.33–0.96, p = 0.04) for enhancing tumor area, 0.58 (95%CI: 0.34–0.98, p = 0.04) for TTV, and 0.52 (95%CI: 0.30–0.91, p = 0.02) for ETV. TTV and ETV, as well as the largest enhancing tumor diameter and maximum enhancing tumor area, reliably predict the OS of patients with ICC after cTACE and could identify ICC patients who are most likely to benefit from cTACE.
U-survival for prognostic prediction of disease progression and mortality of patients with COVID-19
Authors: Näppi Janne J. , Uemura Tomoki , Watari Chinatsu , Hironaka Toru , Kamiya Tohru , Yoshida Hiroyuki 
Published: April 2021

AbstractThe rapid increase of patients with coronavirus disease 2019 (COVID-19) has introduced major challenges to healthcare services worldwide. Therefore, fast and accurate clinical assessment of COVID-19 progression and mortality is vital for the management of COVID-19 patients. We developed an automated image-based survival prediction model, called U-survival, which combines deep learning of chest CT images with the established survival analysis methodology of an elastic-net Cox survival model. In an evaluation of 383 COVID-19 positive patients from two hospitals, the prognostic bootstrap prediction performance of U-survival was significantly higher (P < 0.0001) than those of existing laboratory and image-based reference predictors both for COVID-19 progression (maximum concordance index: 91.6% [95% confidence interval 91.5, 91.7]) and for mortality (88.7% [88.6, 88.9]), and the separation between the Kaplan–Meier survival curves of patients stratified into low- and high-risk groups was largest for U-survival (P < 3 × 10–14). The results indicate that U-survival can be used to provide automated and objective prognostic predictions for the management of COVID-19 patients.
Anthropogenic nitrate in groundwater and its health risks in the view of background concentration in a semi arid area of Rajasthan, India
Authors: Rahman Abdur , Mondal N. C. , Tiwari K. K. 
Published: April 2021

AbstractAn increased nitrate (NO3−) concentration in groundwater has been a rising issue on a global scale in recent years. Different consumption mechanisms clearly illustrate the adverse effects on human health. The goal of this present study is to assess the natural and anthropogenic NO3− concentrations in groundwater in a semi arid area of Rajasthan and its related risks to human health in the different groups of ages such as children, males, and females. We have found that most of the samples (n = 90) were influenced by anthropogenic activities. The background level of NO3− had been estimated as 7.2 mg/L using a probabilistic approach. About 93% of nitrate samples exceeded the background limit, while 28% of the samples were beyond the permissible limit of 45 mg/L as per the BIS limits. The results show that the oral exposure of nitrate was very high as compare to dermal contact. With regard to the non-carcinogenic health risk, the total Hazard Index (HITotal) values of groundwater nitrate were an average of 0.895 for males, 1.058 for females, and 1.214 for children. The nitrate health risk assessment shows that about 38%, 46%, and 49% of the samples constitute the non-carcinogenic health risk to males, females, and children, respectively. Children were found to be more prone to health risks due to the potential exposure to groundwater nitrate.
Development of a permanent vacuum hollow prism air refractometer for use in dimensional metrology
Authors: Kruger O. , Chetty N. 
Published: April 2021

AbstractRefractive index measurements are required when light is used as the basis of a measurement system. In dimensional metrology, refractive index measurements are used to compensate for the change in the speed of light. This is crucial because the SI unit for the metre is defined as the speed of light in a vacuum. Air refractometers are the most accurate way to measure the speed of light in air. Many research works to date have been performed to measure the refractive index of air using refractometers. This research uses a commercial prism as the vacuum etalon instead of the tube that is used most often. This novelty and newness of our research were to focus on the design, fabrication and testing of a refractometer which uses a permanent vacuum for ease of use but that will still have the same accuracy of other refractometers currently in use. Modifications to existing designs improved the long-term stability compared to other prism refractometers and are also potentially more accurate than tube refractometers. The results achieved with this permanent vacuum refractometer are accurate to 8.4 × 10–8, which compares favourably with other refractometers on accuracy. It also has the added advantage that it does not require a vacuum pump, and with added laser path improved long term stability but still portable and robust enough to use in everyday applications.