bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardioprotective mechanisms of sodium-glucose cotransporter 2 inhibitors
Authors: Mkrtumyan A. M. , Markova T. N. , Mishchenko N. K. 
Published: September 2021

The findings of large-scale cardiovascular outcome trials have been demonstrated that sodium-glucose cotransporter 2 ­inhibitors (iSGLT-2) have shown beneficial cardiovascular effects. In this review proposed mechanisms underlying iSGLT-2-associated cardiovascular benefits have been discussed: haemodynamic and intracellular effects, including metabolic effects and electrolyte changes; and also, the effect on markers of cardiovascular disease (CVD). The hemodynamic effects of SGLT-2 are characterized by reduction of cardiac preload and afterload as a result of osmotic diuresis, a decrease in blood pressure and arterial stiffness. The metabolic effects of this medicine are accompanied by an increase the production of ketone bodies, followed by improving ATP production and myocardial energetics. Also, iSGLT-2 modulate ion transporters (NHE1 and NHE3). A reduction of cytoplasmic sodium and calcium levels and increasing mitochondrial calcium levels in the cardiomyocytes enhances the synthesis of ATP and increases cell viability. Effect of iSGLT-2 on CVD markers showed a decrease in the levels of the N-terminal pro-B-type natriuretic peptide and highly sensitive troponin I in elderly patients with type 2 diabetes mellitus (T2DM). Thus, this class of agents has a multifactorial effect on the functioning of cardiovascular system. Further studies will help to explain the all possible cardioprotective effects of iSGLT-2 in individuals with and without T2DM.
The influence of external environment on workers on scaffolding illustrated by UTCI
Authors: Szer Iwona , Szer Jacek 
Published: September 2021

Abstract
The aim of the article was to present the influence of the external environment on people working on scaffolding. For this purpose, the heat load of a man was determined using the universal thermal climate index. The research was carried out on 40 facade scaffolds located in four voivodeships in Poland: Lower Silesia, Lublin, Lodzkie, and Masovian. The conducted analysis showed that employees may experience strong or very strong heat stress, and also extreme heat stress in isolated cases. The highest probability at 0.30 level occurs on scaffolds located in the Lodzkie voivodeship. Environmental conditions are therefore unfavourable for people working outside. This can lead to reduced concentration, longer reaction time, and greater fatigue, contributing to an increase in situations that could lead to accidents. Hazard identification allows to take safety measures that improve the comfort of work on scaffolding.
Does acupuncture improve sexual dysfunction? A systematic review
Authors: Abdi Fatemeh , Alimoradi Zainab , Roozbeh Nasibeh , Amjadi Marjan Akhavan , Robatjazi Mehri 
Published: September 2021

Abstract

Objectives
Sexual dysfunction can adversely affect the quality of life and interpersonal relationships. nowadays, a lot of attention is paid to traditional Chinese medicine with better curative effects and less adverse events. Recent studies have implied the promising effect of acupuncture on sexual function. This systematic review evaluate the effectiveness and safety of acupuncture in treating female and male sexual dysfunction.

Content
PubMed, Cochrane Central of Controlled Trials (CENTRAL), EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Scopus, and Google Scholar were searched up to 2021. No limitation to language and date. The methodological quality of the studies was assessed using the Mixed Methods Appraisal Tool (MMAT).

Summary
Among 160 initially assessed papers, 13 articles were included. The findings showed that acupuncture improve sexual dysfunction in domains of desire, libido, erectile dysfunction and impotency. Most studies did not report any serious side effects from acupuncture, and only three studies reported minor adverse events.

Outlook
The available evidence indicate that acupuncture has positive on improvement of sexual dysfunction with no serious side effects. Although acupuncture has gained increasing popularity for the management of sexual dysfunction, high methodological quality evidence regarding its efficacy is lacking.
Developing strategies for conceptual accessibility through multimodal literacy in the English for tourism classroom
Authors: Bonsignori Veronica , Cappelli Gloria 
Published: September 2021

Abstract
Teaching English for Tourism at university involves both developing specialized language skills and forming knowledgeable professionals capable of appropriate intercultural communication. The distinctive feature of most instances of tourism discourse is the fact that it draws from a range of specialized domains. It mediates the tourist experience and contributes to closing the gap between the home- and the destination’s culture by making culture-specific knowledge and specialized concepts accessible to non-specialists. The article discusses the instructional effects of authentic multimodal materials within task-based project-work carried out with learners at the University of Pisa. The focus is specifically on the communicative strategies used to make specialized terminology or concepts easily understandable for the hearer. This study reports on a multimodal analysis of two sets of videoclips created by the students before and after dedicated instruction based on authentic English L1 clips from documentaries, “docu-tours” and guided tours. It discusses the positive changes observed in the learners’ use of popularization strategies to create conceptual accessibility.
Crystal structure of 1,1′-(1,3-phenylenebis(methylene))bis(pyridin-1-ium) bis(1,2-dicyanoethene-1,2-dithiolato-κ2
S:S) palladium(II), C26H18N6PdS4
Authors: Liu Xue-Guo , Pan Hui-Yan 
Published: September 2021

Abstract
C26H18N6PdS4, monoclinic, C2/c (no. 15), a = 16.658(2) Å, b = 10.398(3) Å, c = 17.284(2) Å, β = 116.928(3)°, V = 2669.2(9) Å3, Z = 4, R

gt
(F) = 0.0330, wR

ref
(F
2) = 0.0912, T = 293(2) K.
Between spatial domain and grammatical meaning: The semantic content of English telic particles
Authors: Konieczna Ewa 
Published: September 2021

AbstractThe purpose of this article is to demonstrate that English spatial particles which have grammaticalised into telic aspectualisers are not devoid of the image schematic content, which motivates their use in specific contexts. Because aspectual meaning, including telicity, is compositional in nature, which means that it frequently results from the interaction of several linguistic features, it is vital to single out those predicates in which the telicity effect can be attributed solely to the particle, not any other elements of the construction. This can be implemented by adopting the scalar approach, which shows that telicity is entailed by the particle exclusively in a predicate containing an incremental theme verb. Accordingly, the incremental theme verbburnand its five telic particles (up,down,out,offandaway) constitute the subject of investigation. The analysis demonstrates that each particle encodes telicity in terms of reaching the GOAL in the SOURCE-PATH-GOAL schema. Conceptual differences in encoding the termination of the burning process result from topological properties of the path construed by each particle under study.
Criminal Liability for the Misappropriation of Authorship from 1830s to Early 20th Century
Authors: Žiedė Ramunė 
Published: September 2021

This article analyzes the development of criminal liability for the misappropriation of authorship in Lithuania in the period of application of the legal acts of Tsarist Russia from the 1830s until the restoration of Lithuania’s independence in early 20th century. Norms of different periods are being compared with each other, the oldest criminal norm for the misappropriation of authorship is sought and identified. The appendices of the article also present the citation of the norms of misappropriation of authorship in the original (19th century Russian) language and its translation into Lithuanian, as well as a graph depicting norms of misappropriation of authorship, established in different legal acts, their correlation at different times, and the content of the norms in force with each other.
Biomass production and nutritional properties of promising genotypes of <i>Tithonia diversifolia</i> (Hemsl.) A. Gray under different environments
Authors: Rivera Julián Esteban , Ruíz Tomás E. , Chará Julián , Gómez-Leyva Juan Florencio , Barahona Rolando 
Published: September 2021

Tithonia diversifolia is a shrub with excellent forage characteristics that has shown a wide genetic and phenotypic diversity. The objective of this study was to determine the biomass production and nutritional quality of seven genotypes of T. diversifolia with outstanding characteristics for ruminant nutrition, to analyze the Genotype x Environment (GxE) interaction of biomass production and to compare the performance of these genotypes with grasses offered normally in tropical conditions. For the GxE interaction the AMMI and SREG models were used, and evaluations were made in three environments. In the GxE analysis, the interaction was significant and effects of the environment on biomass productivity were observed with differences between genotypes (p <0.05). In the three environments, the chemical composition was adequate to be offered to ruminants. It is worth noting the high content of crude protein (28.89 g/100 g of dry matter - DM), the low fiber content (30.95 g of neutral detergent fiber - NDF/100 g of DM) and the high percentages of in vitrodegradation of DM for all the genotypes. It is possible to conclude that there are superior genotypes of T. diversifolia with the ability to have good productive and adaptive performance for high-altitude and low-altitude zones with low fertility soils.
IOP change after phacoemulsification with PCIOL implantation and its association with ocular biometric parameters
Authors: Rahman Sharah , Ahmed Jalal , Rahman Anisur , Anwar Ishtiaque , Zafrullah Tarzia Asma , Mitu Sharifa Zahan , Chowdhury Mahziba Rahman , Ul Kadir Syeed Mehbub 
Published: September 2021

: To assess the impact on intraocular pressure (IOP) after Phacoemulsification (PE) with Posterior Chamber Intraocular Lens (PCIOL) implantation and its relation with ocular biometric parameters. The study was a prospective observational study included 524 eyes with normal IOP (11-21 mmHg) who underwent uneventful Phacoemulsification with PCIOL Implantation surgery for age-related cataract. IOP, Central Corneal Thickness (CCT), Anterior Chamber Depth (ACD), Axial Length (AL) were measured pre-operatively and one month post-operatively by Goldman Applanation Tonometer, Corneal Pachymeter and Optical Coherence Biometer, respectively. The post-operative IOP change and its relation with preoperative biometric parameters were determined.: The mean pre-operative and post-operative IOP was 13.44±1.98 & 11.54±1.66mmHg, respectively, with an average IOP reduction after one month of 1.90±0.61mmHg. The mean pre-operative and post-operative ACD was 3.27±0.24 and 3.66±0.27 mm, respectively, with an average increase of 0.39 ±0.3 mm. Paired t-test showed post-operative IOP reduction was significantly associated with preoperative IOP (p&#60;0.001) and ACD (p&#60;0.001). But CCT and AL were not significantly associated. The linear regression analysis confirmed the proportional reduction of post-operative IOP, r 0.921. So 92.1% of the preoperative IOP is proportional to post-operative IOP reduction. The graphical representation shows more the pre-operative IOP, more the post-operative IOP reduction.: IOP is significantly reduced, and ACD increased after PE with PCIOL implantation surgery and is associated with post-operative IOP reduction. The post-operative IOP reduction is proportional to pre-operative IOP, and more the preoperative IOP, more the post-operative IOP reduction.
A comparison of axial length measurement by using applanation A- Scan and IOL master for accuracy of predicting postoperative refraction
Authors: Trivedi Harish R , Zala Bhavik C , Pancholi Nitesh S 
Published: September 2021

The higher cost of IOL master is an issue in developing countries and hence it cannot be widely used for calculation of IOL power in such countries. Thus, the aim of the current study is to evaluate a cheaper alternative for the calculation of IOL power by comparing the axial length measurement obtained using applanation A-scan with that of IOL Master for accuracy of predicting postoperative refraction.A prospective, randomized, comparative study was done with 100 patients who were posted for cataract surgery. The patients were randomly divided into two groups of 50 patients each using computerized random number method. In Group A (n=50) axial length was measured with applanation A-scan and in Group B (n=50) axial length was measured with IOL Master. Before cataract surgery keratometry reading was taken with auto keratometer and intraocular lens (IOL) power calculation was done using SRK 2 formula in all patients. All patients were operated for cataract surgery by phacoemulsification and foldable intraocular lens were implanted in the bag. Postoperatively, best accepted refraction at 8th week was taken and mean spherical equivalent was calculated. 100 patients of cataract were subjected for cataract surgery by phacoemulsification.Corrected spherical equivalent on 8th postoperative week showed: 88% patients in Group A and 96% patients of Group B were within ± 1.00 D.56% patients of Group A and 76% patients of Group B were within ± 0.50 D.There was no statistically significant difference (p &#62; 0.05) in axial length and corrected spherical equivalent between the two groups. There is no extra advantage of IOL Master over applanation A-scan for measuring Axial Length between 21 and 24.50 and predicting post-operative refractive outcome.
Clinical profile and outcomes of descemetopexy in descemet membrane detachment (DMD) post-cataract surgery
Authors: Chawla Harshika , Vohra Vishal , Khan Asif , Bareja Monika 
Published: September 2021

To identify the preoperative risk factors, type of cataract surgery, cataract grade, and final visual outcome in patients undergoing descemetopexy for DMD. This was a retrospective study in which records of patients who underwent descemetopexy with either air or 20% sulfur hexafluoride (SF6) between 1st July 2014 and 30th June 2017. Grade of cataract, type of surgery, visual outcomes, and site of DMD were recorded.The mean age of the patients was 63.21 ± 5.8 years. Of the total 23 cases undergoing descemetopexy, 20 cases (87%) were after manual small incision cataract surgery (MSICS) and three cases (13%) were post phacoemulsification. The mean duration of presentation with a detachment was 13.03± 10.9 days (1-40 days). The most common types of DMD were total (34.8%) followed by temporal (30.4%) and superior (26.1%). Two patients (8.6%) obtained LOGMAR visual acuity (VA) of 0.0 and 5 of 23 patients (21.7%) achieved LOGMAR VA 0.3 after descemetopexy. Reattachment rates were 87% and three cases had reintervention. : This study identifies mature cataract and pre-existing corneal pathology as major risk factors for DMD during cataract surgery. DMD can be treated effectively and good visual outcome after successful descemetopexy.
A prospective study to evaluate the predictive value of ocular trauma score in cases of mechanical eye injuries in a tertiary care hospital
Authors: Kumar Arvind , Verma Rupali , Shukla Abha 
Published: September 2021

Ocular trauma score (OTS) was proposed to predict the visual outcome of patients after ocular trauma, which estimates visual function (visual acuity) after 6 months of ocular trauma. This OTS scale is useful for guiding the treatment and rehabilitation of the patients with eye injury and to provide the valuable information and advice. Aim of this study was to evaluate the predictive value of OTS in cases of mechanical ocular trauma. A prospective interventional study was carried out in a tertiary care centre over a period of 2 years; August 2017 to July 2019. Patients with mechanical eye trauma were included in the study. OTS score was calculated and recorded for each eye at the time of injury. Proper treatment given to each case and followed for six months. Results obtained were compared with standard OTS with respect to final VA. Out of 50 patients mean age was 28.46 years, with majority between 21 to 50 years of age. There were 78% males and 22% were females. Metallic objects were the common source of injury in 27 cases (54%) like iron rod and nail. In cases (fifty eyes) the distribution of OTS variables was; globe rupture 86% (43 eyes), retinal detachment 6% (3 eyes), relative afferent pupillary defect (RAPD) 6% and endophthalmitis 2% (1 eye) respectively. The final visual acuities in OTS categories in our study groups were similar to those in the OTS study group, except for some categories. OTS helps treating ophthalmic team to assess evidence based prognosis of a traumatized eye in advance. With the guidance of OTS the patient and their family can be counselled for further management.
Comparitive study between normal tension glaucoma and primary open-angle glaucoma
Authors: Shree B V Sowmya , Bharathi N  , Kumari C Shwetha , Sadananda Ranjitha C , Khanapur Madhura M 
Published: September 2021

The study is conducted to determine the functional and structural differences between NTG and POAG, to assess the rate of conversion of NTG into POAG and its early intervention. It is a hospital based prospective, cross-sectional study of 56 NTG and 56 POAG patients. History was taken and comprehensive ophthalmic examination with glaucoma work up was done.Majority of the patients belonged to the age group between 51 and 60 years i.e. 48.2% in NTG and 62.5% in POAG. Majority of the NTG patients i.e. 33 (58.9%) were females while 41(73.2%) were males in POAG. 40% of NTG patients had systemic association like bronchial asthma, diabetes, hypertension, ischemic heart disease and migraine. There was no significant difference in CDR between two groups. Inferior & temporal neuroretinal rim thinning was more common in NTG. While bipolar thinning & superior rim thinning was more common in POAG. There is significantly more thinning of RNFL in POAG than NTG. The mean deviation (MD) & pattern standard deviation (PSD) in visual fields between NTG & POAG showed no significant difference. Whereas the field loss was near centre of fixation in NTG group compared to POAG which was diffuse. These differences between NTG and POAG suggest that the pathogenesis of NTG includes IOP and IOP independent risk factors, while IOP is the main risk factor in POAG. The parameters assessed determine the risk and progression of NTG to POAG.
Retinal vasculitis – Clinical manifestations and outcome at tertiary eye care centre in south India
Authors: Sultana Aliya , Sharath Kumar T 
Published: September 2021

To study the various causes, clinical presentation, management and outcome of the retinal vasculitis cases at tertiary eye care centre. Tertiary eye care centre, Telangana State, South India. Retrospective Interventional Study. Jan 2016 to Dec 2020. Fifty one patients of retinal vasculitis presented with various clinical manifestations were examined in detail and managed. Data collected from medical records. All young patients of different age group presented with retinal vascular changes are included in the study. Patients underwent examination and laboratory workup. Few patients showed ocular and systemic investigations were with in the normal limits. These patients were considered as idiopathic cases. BCVA, slit lamp examination, fundus examination, FFA, OCT, B SCAN in hazy media and documentation done in all cases. Bilateral presentation was common, some presented with aggressive disease in both eyes (early and delayed presentation). Common presentation was blurred vision and sudden drop of vision. Few patients showed tuberculin skin test positive and managed as presumed ocular tuberculosis. Patients who were HIV positive managed with HART, prognosis was poor in these patients. Medical and surgical management done based on the stage of presentation, oral steroids, laser therapy, anti VEGF followed by pars plana vitrectomy with or with silicone oil tamponade done. Oral steroids were started after physician clearance and tapered based on the activity of the disease. Patients followed regularly every month till the activity ceases in medically managed cases and in operated cases we followed till the silicone oil is removed from the eye. Few patients presented with the reactivity of the disease were managed again based on the presentation. Results were good in idiopathic cases, patients presented with inflammatory and ischemic stages also showed good outcome. Patients presented with proliferative stage showed fair outcome, patients presented with severe proliferative stage showed poor prognosis. Retinal vasculitis is one of the ocular condition which can cause vision loss in young adults, if present in early stage, can be managed medically. Prognosis is good in early stages. Recurrent vitreous haemorrhage, tractional retinal detachment, combined retinal detachment were common presentations. Infective cases showed more proliferative changes. Risk of neovascular glaucoma is one of the cause of blindness.
Efficacy of rural camps in achieving vision 2020: Our contribution
Authors: Gajapati Charushila Gajapati , Patil Shankargauda H , Desai Anupama 
Published: September 2021

: To assess the effectiveness of rural camps held under DBCS (District Blindness Control Programme) & compare the results of cataract surgery at base hospital cases. It is a retrospective observational study, medical records of patients operated for cataract in camp & patients operated in base hospital are analyzed.In our hospital outpatient department, we saw 2,08,716 patients from 2010-2019 and 7796 underwent cataract surgery. Under DBCS we conducted 262 camps from 2010-2019 & 4611 underwent cataract surgery.A total of 27,524 patients got screened in 262 rural camps and 4671 underwent small incision cataract surgery at the base hospital after detailed clinical examination and IOL (intraocular lens) power calculation for each patient. Among 2,08,716 outpatients at the base hospital, 7796 underwent cataract surgery. The rate of intraoperative complications in the base hospital was 0.885% whereas in camp cases 1.94%.IOL implantation is done in 100%cases in base hospital surgeries and 0.064%patients left aphakic among rural camps.Screening at outreach camps and surgeries at the base hospital can have excellent results. Mass surgeries in camps following standard protocol can have the least number of complications.
FEJLESZTŐPROGRAMOK HATÁSVIZSGÁLATÁT SZOLGÁLÓ ADATBÁZISOK SZERKEZETE EGY INGYENES STATISZTIKAI SZOFTVERBEN: AZ R-BEN
Authors: Abari Kálmán , Mező Ferenc , Mező Katalin , Máth János 
Published: September 2021

A (gyógy)pedagógiai fejlesztőprogramok matematikai statisztikai alapokon nyugvó hatásvizsgálatához lényeges: 1) ismerni a minimálisan szükséges matematikai alapfogalmakkal (ezeket lásd: Máth és tsai, 2015), 2) egy megfizethető áru statisztikai szoftver, 3) e szoftverek alkalmazásához szükséges - legalább felhasználói szintű – jártasság is. E két utóbbi szükségletre nyújt praktikus megoldást jelen tanulmány, miközben bemutatja az R nyelvet, s annak lehetőségeit. Az R egy ingyenesen letölthető, matematikai statisztikai számítások végrehajtására is alkalmas szoftver, mely praktikus segédeszköze lehet a különleges bánásmódot igénylők kutatásának. Jelen tanulmány az R-ről szóló rövid tájékoztatót követően a kutatások során keletkezett adatok adatbázissá, adattáblává szervezését foglalja össze a fejlesztőprogramok hatásvizsgálatának három jellegzetes esetében.