bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of synthesis parameters on crystallization behavior and ionic conductivity of the Li4PS4I solid electrolyte
Authors: Strauss Florian , Lin Jing , Janek Jürgen , Brezesinski Torsten 
Published: July 2021

AbstractSuperionic solid electrolytes are key to the development of advanced solid-state Li batteries. In recent years, various materials have been discovered, with ionic conductivities approaching or even exceeding those of carbonate-based liquid electrolytes used in high-performance Li-ion batteries. Among the different classes of inorganic solid electrolytes under study, lithium thiophosphates are one of the most promising due to their high Li-ion conductivity at room temperature and mechanical softness. Here, we report about the effect of synthesis parameters on the crystallization behavior and charge-transport properties of Li4PS4I. We show that thermally induced crystallization of Li4PS4I (P4/nmm), starting from the glassy phase 1.5Li2S–0.5P2S5–LiI, adversely affects the material’s conductivity. However, both conductivity and crystallization temperature can be significantly increased by applying pressure during the preparation.
Comparison of retrograde intrarenal surgery and standard percutaneous nephrolithotomy for management of stones at ureteropelvic junction with high-grade hydronephrosis
Authors: Wang Fang , Hong Yun , Yang Zesong , Ye Liefu 
Published: July 2021

AbstractPercutaneous nephrostomy (PCNL) and retrograde intrarenal surgery (RIRS) are the two main treatments for upper urinary tract stones. The aim of our study was to compare the effectiveness and safety of standard PCNL (S-PCNL) and RIRS for the treatment of stones at ureteropelvic junction with high-grade hydronephrosis. The study included 118 patients who underwent surgery for stones at ureteropelvic junction. S-PCNL and RIRS were performed on 66 and 52 patients, respectively. Patient age, sex, body mass index (BMI), stone side, history of urinary tract infection (UTI), history of diabetes, history of ESWL, stone size, Hounsfield unit (HU) values of stones, grade of hydronephrosis, operating time, postoperative hemoglobin loss, narcotic analgesic use, postoperative transfusion rates, stone-free rates (SFRs), length of hospital stay, complication rates and number of secondary interventions were recorded. The comparison of the operative data between the two groups revealed no statistically significant differences in the operative time, SFRs, narcotic analgesic use, postoperative transfusion rate or other postoperative complications defined according to the Clavien system (P > 0.05). The postoperative urinary sepsis rate in the RIRS group was as high as 15.4%, which was much higher than the 1.5% rate observed in the S-PCNL group, and the difference was statistically significant (P < 0.05). A total of 13.5% of the patients in the RIRS group required a second operation due to failure of the placement of the ureteral access sheath. Additionally, S-PCNL had an advantage in operation time, while RIRS in duration of hospital stay and postoperative hemoglobin loss. RIRS and S-PCNL were safe and effective methods for the treatment of stones at ureteropelvic junction with high-grade hydronephrosis. Importantly, S-PCNL had more advantages in terms of the postoperative urinary sepsis rate and secondary surgery rate.
Calmodulin-dependent KCNE4 dimerization controls membrane targeting
Authors: Roig Sara R. , Solé Laura , Cassinelli Silvia , Colomer-Molera Magalí , Sastre Daniel , Serrano-Novillo Clara , Serrano-Albarrás Antonio , Lillo M. Pilar , Tamkun Michael M. , Felipe Antonio 
Published: July 2021

AbstractThe voltage-dependent potassium channel Kv1.3 participates in the immune response. Kv1.3 is essential in different cellular functions, such as proliferation, activation and apoptosis. Because aberrant expression of Kv1.3 is linked to autoimmune diseases, fine-tuning its function is crucial for leukocyte physiology. Regulatory KCNE subunits are expressed in the immune system, and KCNE4 specifically tightly regulates Kv1.3. KCNE4 modulates Kv1.3 currents slowing activation, accelerating inactivation and retaining the channel at the endoplasmic reticulum (ER), thereby altering its membrane localization. In addition, KCNE4 genomic variants are associated with immune pathologies. Therefore, an in-depth knowledge of KCNE4 function is extremely relevant for understanding immune system physiology. We demonstrate that KCNE4 dimerizes, which is unique among KCNE regulatory peptide family members. Furthermore, the juxtamembrane tetraleucine carboxyl-terminal domain of KCNE4 is a structural platform in which Kv1.3, Ca2+/calmodulin (CaM) and dimerizing KCNE4 compete for multiple interaction partners. CaM-dependent KCNE4 dimerization controls KCNE4 membrane targeting and modulates its interaction with Kv1.3. KCNE4, which is highly retained at the ER, contains an important ER retention motif near the tetraleucine motif. Upon escaping the ER in a CaM-dependent pattern, KCNE4 follows a COP-II-dependent forward trafficking mechanism. Therefore, CaM, an essential signaling molecule that controls the dimerization and membrane targeting of KCNE4, modulates the KCNE4-dependent regulation of Kv1.3, which in turn fine-tunes leukocyte physiology.
Drying and temperature induced conformational changes of nucleic acids and stallion sperm chromatin in trehalose preservation formulations
Authors: Brogna Raffaele , Fan Juezhu , Sieme Harald , Wolkers Willem F. , Oldenhof Harriëtte 
Published: July 2021

AbstractEven though dried sperm is not viable, it can be used for fertilization as long as its chromatin remains intact. In this study, we investigated drying- and temperature-induced conformational changes of nucleic acids and stallion sperm chromatin. Sperm was diluted in preservation formulations with and without sugar/albumin and subjected to convective drying at elevated temperatures on glass substrates. Accumulation of reactive oxygen species was studied during storage at different temperatures, and the sperm chromatin structure assay was used to assess DNA damage. Fourier transform infrared spectroscopy was used to identify dehydration and storage induced conformational changes in isolated DNA and sperm chromatin. Furthermore, hydrogen bonding in the preservation solutions associated with storage stability were investigated. Reactive oxygen species and DNA damage in dried sperm samples were found to accumulate with increasing storage temperature and storage duration. Non-reducing disaccharides (i.e., trehalose, sucrose) and albumin counteracted oxidative stress and preserved sperm chromatin during dried storage, whereas glucose increased DNA damage during storage. When sperm was dried in the presence of trehalose and albumin, no spectral changes were detected during storage at refrigeration temperatures, whereas under accelerated aging conditions, i.e., storage at 37 °C, spectral changes were detected indicating alterations in sperm chromatin structure.
Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization
Authors: Hu Liuying , Hayashi Yumiko , Kidoya Hiroyasu , Takakura Nobuyuki 
Published: July 2021

AbstractThe Apelin/APJ signalling pathway, involved in multiple physiological and pathological processes, has been attracting increasing interest recently. In our previous study, Apelin overexpression in colon26 tumor cells suppressed tumor growth by inducing vascular maturation. Here, we found that MC38 and LLC tumor growth were greater in the absence of Apelin than in wild-type (WT) mice, suggesting that Apelin acts as a tumor suppressor. Consistent with this, treating WT mice with [Pyr1]Apelin-13 inhibited tumor growth. In MC38 tumors, only endothelial cells (ECs) strongly express APJ, a cognate receptor for Apelin, indicating that EC-derived Apelin might regulate tumor formation in an autocrine manner. Comparing with WT mice, larger numbers of vessels with narrower diameters were observed in tumors of Apelin knockout mice and lack of Apelin enhanced tumor hypoxia. Investigating immune cells in the tumor revealed that [Pyr1]Apelin-13 infusion induced the accumulation of CD8+ and CD4+ T cells in central areas. Moreover, RNA-sequencing analysis showed that Apelin induces chemokine CCL8 expression in ECs. Thus, enhancing anti-tumor immunity might be one of the mechanisms by which Apelin is involved in tumor growth. Our result indicated that increased CCL8 expression might induce CD8 +  T cells infiltration into tumor and tumor inhibition.
Coating matching recommendation based on improved fuzzy comprehensive evaluation and collaborative filtering algorithm
Authors: Xin Yuan , Henan Bu , Jianmin Niu , Wenjuan Yu , Honggen Zhou , Xingyu Ji , Pengfei Ye 
Published: July 2021

AbstractCoating matching design is one of the important parts of ship coating process design. The selection of coating matching is influenced by various factors such as marine corrosive environment, anti-corrosion period and working conditions. There are also differences in the coating performance requirements for different ship types and different coating parts. At present, the design of coating matching in shipyards depends on the experience of technologist, which is not conducive to the scientific management of ship painting process and the macro control of ship construction cost. Therefore, this paper proposes a hybrid algorithm of fuzzy comprehensive evaluation and collaborative filtering based on user label improvement (IFCE-CF). Based on the analytic hierarchy process (AHP), the evaluation index system of coating matching is constructed, and the weight calculation process of fuzzy comprehensive evaluation is optimized by introducing the user label weight. The collaborative filtering algorithm based on matrix decomposition is used to realize the accurate recommendation of coating matching. Historical coating process data of a shipyard between 2010 and 2020 are selected to verify the recommendation ability of the method in the paper. The results show that using the coating matching intelligent recommendation algorithm proposed in this paper, the root mean square error is < 1.02 and the mean absolute error is < 0.75, the prediction accuracy is significantly better than other research methods, which proves the effectiveness of the method.
Testing the foundation of quantum physics in space via Interferometric and non-interferometric experiments with mesoscopic nanoparticles
Authors: Gasbarri Giulio , Belenchia Alessio , Carlesso Matteo , Donadi Sandro , Bassi Angelo , Kaltenbaek Rainer , Paternostro Mauro , Ulbricht Hendrik 
Published: July 2021

AbstractQuantum technologies are opening novel avenues for applied and fundamental science at an impressive pace. In this perspective article, we focus on the promises coming from the combination of quantum technologies and space science to test the very foundations of quantum physics and, possibly, new physics. In particular, we survey the field of mesoscopic superpositions of nanoparticles and the potential of interferometric and non-interferometric experiments in space for the investigation of the superposition principle of quantum mechanics and the quantum-to-classical transition. We delve into the possibilities offered by the state-of-the-art of nanoparticle physics projected in the space environment and discuss the numerous challenges, and the corresponding potential advancements, that the space environment presents. In doing this, we also offer an ab-initio estimate of the potential of space-based interferometry with some of the largest systems ever considered and show that there is room for tests of quantum mechanics at an unprecedented level of detail.
Affine projection Weibull M‐transform least mean square algorithm against impulsive interference
Authors: Liu Pingchuan , Fan Kuangang , Qiu Haiyun 
Published: July 2021

AbstractThe well‐known affine projection sign algorithm is one of the classic adaptive filtering methods for denoising and channel equalisation, which can achieve robust performance against coloured input and impulse noise. This work proposes the affine projection Weibull M‐transform least mean square algorithm to improve the steady‐state performance of affine projection algorithms. The proposed algorithm combines the Weibull M‐transform cost function with the L2‐norm constraint of weight vector to improve the performance of existing affine projection algorithms and achieve a better convergence rate and better misalignment. This novel algorithm also preserves good performance against impulsive interference and coloured input. Simulation results demonstrated that the proposed algorithm has a remarkable improvement in convergence performance compared with other algorithms.
A deep learning method for video‐based action recognition
Authors: Zhang Guanwen , Rao Yukun , Wang Changhao , Zhou Wei , Ji Xiangyang 
Published: July 2021

AbstractIn this paper, a deep learning method for video‐based action recognition is proposed. On the one hand, boundary compensation on the basis of a deep neural network is performed to achieve action proposal. Boundary compensation considering non‐maximum suppression according to sliding window priority is applied to remove redundant windows. To accurately detect boundaries, a boundary compensation network is established with multiple networks to process different numbers of segments. On the other hand, action recognition based on the resultant action proposals is performed. To further utilise boundary compensation, three methods are introduced for key frame selection. Optical flow and RGB features are combined via a channel fusion to realise feature representation. A two‐stream network with a spatiotemporal structure is adopted for action recognition. The proposed method is evaluated on three public datasets. The experimental results demonstrate that the proposed method achieves a superior performance to that of state‐of‐the‐art methods.
Grating lobe suppression in focussed energy delivery for precision electronic warfare
Authors: Yang Zhong‐ping , Zhou Qing‐song , Li Zhi‐hui , Zhang Jian‐yun , Yang Shu‐ning 
Published: July 2021

AbstractFocussed energy delivery (FED), which transmits energy to a specific area by ultrasparse arrays, is the core technique of precision electronic warfare (PREW). However, array sparsity results in severe grating lobes in practice, which greatly increase the risks of an interference system being attacked and unexpected jamming occurring in other devices. Here, two methods are presented which are aimed at suppressing grating lobes when implementing FED in the application of PREW to avoid the problems mentioned. Regarding the first method, a new metric based on the ‐norm is proposed to measure the maximum grating lobe and introduce the metric to the standard FED model. A multiobjective optimisation problem (MOP) is established and solved by the alternating direction penalty method (ADPM) framework. In the second method, the degrees of freedom of the transmitted signals are extended by equipping each platform with a group of linear uniform antennas. The corresponding MOP is established and block coordinate descent is employed to simplify the problem into two subproblems concerning the amplitude and phase components of the transmitted signals. Then, these two subproblems are solved using Taylor expansion and the ADPM framework. Simulation results are provided to demonstrate the advantages of the proposed methods over the state‐of‐the‐art methods.
Einordnung ankylosierter Zähne im digitalen Zeitalter
Authors: Wilmes Benedict , Willmann Jan , Bräutigam Martina , Bonitz Lars , Drescher Dieter 
Published: July 2021

ZusammenfassungAnkylosierte Zähne sind eine große Herausforderung im Rahmen einer kieferorthopädischen Behandlung. Neben der Extraktion, der Transplantation, dem konventionellen Einordnungsversuch nach Lockerung, sowie der ossären Distraktion stellt die parodontale Distraktion (PDL-Distraktion) eine sehr effektive Methode zur Einordnung ankylosierter Zähne dar. Auch bei unsicherer langfristiger Prognose von Zähnen mit Defekten kann mittels PDL-Distraktion Knochen sowie Weichgewebe in der oft defizitären Region generiert werden. Neue CAD-CAM-Techniken wie Insertionsguides und Metalldruck mittels Lasersintering optimieren das Verfahren der PDL-Distraktion.
Glukosemessung in der Diabetesdiagnostik und -therapie: Laboratoriumsmedizinische Untersuchung inkl. patientennaher Sofortdiagnostik, Blutglukoseselbstmessung und kontinuierliches Glukosemonitoring
Authors: Pleus Stefan , Heinemann Lutz , Freckmann Guido , Nauck Matthias , Tytko Andrea , Kaiser Patricia , Petersmann Astrid 
Published: July 2021

ZusammenfassungDie Glukose-„Messlandschaft“ in Deutschland deckt viele verschiedene Einsatzzwecke und -gebiete ab. Sie reicht von hochstandardisiert messenden Laboranalysesystemen mit einem großen Gesamtportfolio von Messgrößen bis hin zu einfachen Systemen für den Patientengebrauch. Aus klinischer Sicht muss die Qualität von Glukosemessungen ausreichend hoch sein, um die vorgesehenen Zwecke, also Diagnosestellung und Verlaufskontrolle, zu erfüllen.In der Heilkunde – also bei Messungen im Rahmen der Gesundheitsversorgung durch medizinisches Personal – definiert die Richtlinie der Bundesärztekammer zur Qualitätssicherung laboratoriumsmedizinischer Untersuchungen Vorgaben an die Qualitätssicherung. Es werden sowohl interne als auch externe (herstellerunabhängige) Qualitätskontrollen gefordert und mit spezifischen Vorgaben versehen. Diese Regelungen gelten demnach auch für alle Glukosemessungen in der Heilkunde, d. h. im Zentrallabor ebenso wie in der patientennahen Sofortdiagnostik.Bei dem Haupteinsatzgebiet von Glukosemessungen, der Verlaufskontrolle durch Patienten mit Diabetes im Rahmen der Blutglukoseselbstmessung, fehlen i. d. R. Kontrollen der Messqualität. Für das kontinuierliche Glukosemonitoring im interstitiellen Gewebe sind Qualitätskontrollen nach dem aktuellen technischen Stand sogar überhaupt nicht möglich. Hinzu kommt, dass eine regelmäßige herstellerunabhängige Kontrolle der Messqualität nicht vorgeschrieben ist. Ziel der Arbeit ist es, einen Überblick über die unterschiedlichen Glukosemesssysteme sowie praktische Aspekte und Probleme bei der Glukosemessung zu geben.
Patient Portals: Useful for Whom and for What? A Cross-Sectional Analysis of National Survey Data
Authors: Swoboda Christine M. , DePuccio Matthew J. , Fareed Naleef , McAlearney Ann Scheck , Walker Daniel M. 
Published: July 2021

Abstract
Background Patients who use patient portals may be more engaged and empowered in their care; however, differences in who accesses patient portals remain. The characteristics of who uses patient portals more frequently and who perceives them as useful may also differ, as well as which functions people use.
Objective We assessed the characteristics of patient portal users to examine who uses them more frequently and who perceives them as useful. In addition, we wanted to see if those who use them more frequently or perceive them to be more useful use different functions or more functions of patient portals.
Methods Pooled cross-sectional data from 2017 to 2018 Health Information National Trends Survey (HINTS) were used. Ordinal regression models were developed to assess frequency of use and perceived usefulness by demographics, and multivariable logistic regression models were used to examine the association between the use of 10 patient portal functions and frequency of use and perceived usefulness of patient portals.
Results The odds of using patient portals more frequently were higher among those with Bachelor's degrees, incomes between $35,000 and $75,000, and those with two or more chronic conditions. Respondents with three or more chronic conditions had higher odds of rating patient portals as useful. Those who used their patient portal 10 or more times in the past year had higher odds of using all functions except for viewing test results compared with those who used their patient portal one to two times per year. Those who rated patient portals as “very useful” had higher odds of using seven of the functions compared with those who rated them “not very”/“not at all useful.”
Conclusion It is important to continue to assess usefulness, frequency of use, and overall patient portal function use to identify opportunities to increase patient engagement with patient portals.
Gamma irradiated nanostructured NiFe2O4: Effect of γ-photon on morphological, structural, optical, and magnetic properties
Authors: Sen Sapan Kumar , Babu Md Majibul Haque , Paul Tapash Chandra , Hossain Md. Sazzad , Hossain Mongur , Dutta Supria , Hasan M. R. , Hossain M. N. , Matin M. A. , Hakim M. A. , Bala Parimal 
Published: July 2021

This article highlights the preparation of NiFe2O4 nanoparticles by adopting a sol–gel auto-combustion route. The prime focus of this study is to investigate the impact of γ-irradiation on the microstructural, morphological, functional, optical, and magnetic characteristics. The resulting NiFe2O4 products have been characterized employing numerous instrumental techniques such as Field Emission Scanning Electron Microscopy (FESEM), X-ray Diffraction (XRD), UV–visible spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), and Physical Properties Measurement System for a variety of γ-ray doses (0, 25, and 100 kGy). FESEM micrographs illustrate the aggregation of ferrite nanoparticles in the pristine NiFe2O4 product having an average particle size of 168 nm, and the surface morphology is altered after exposure to γ-irradiation. XRD spectra have been analyzed employing the Rietveld method, and the results of the XRD investigation reveal the desired phases (cubic spinel phases) of NiFe2O4 with the observation of other transitional phases. The values of the crystallite size are in the range of 34.04–34.71 nm investigated by the Debye–Scherrer (D–S) method. Several microstructural parameters, such as bond length, bond angle, and hopping length, have been determined from the analysis of the Rietveld method. This study reports that γ-irradiations demonstrate a great influence on optical bandgap energy, and it varies from 1.80 to 1.89 eV evaluated via the Kubelka–Munk function. The FTIR measurement depicts a proof for the persistence of Ni–O and Fe–O stretching vibrations within the respective products at positions 365 and 547 cm−1, respectively, thus indicating the successful development of NiFe2O4. The saturation magnetization (MS) of the pristine Ni ferrite product is noticed to be 28.08 emu/g. A considerable increase in MS is observed in the case of low γ-dose (25 kGy), and a decrement nature is disclosed after the result of high dose of γ-irradiation (100 kGy).
Modeling links softening of myelin and spectrin scaffolds of axons after a concussion to increased vulnerability to repeated injuries
Authors: Kant Aayush , Johnson Victoria E. , Arena John D. , Dollé Jean-Pierre , Smith Douglas H. , Shenoy Vivek B. 
Published: July 2021

SignificanceGrowing evidence from in vitro studies suggests that the axonal cytoskeleton plays a mechanoprotective role in axon while under dynamic mechanical loads during a traumatic brain injury (TBI). Via computational modeling, we elucidate how perturbations in physical properties of the salient components of axonal cytoskeleton impact the intraaxonal load-bearing mechanism, potentially resulting in its failure. Immunohistochemical analyses of tissue from an in vivo model of TBI confirm the presence of cytoskeletal neurochemical degradation. In conjunction with the experiments, our model explains the clinical observation of exacerbated axonal pathology after repetitive TBIs. Insights from this work can help advance the understanding of the long-term impacts of single and repeated TBIs and identify potential therapeutic targets for improving axonal response to injury.