bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and development of a two-dish interferometer
Authors: Mulumba Dorcus 
Published: January 2021

AbstractThe angular resolution and the sensitivity of a parabolic dish telescope increase with the diameter of its aperture at a given frequency. This implies that as the telescope gets larger, its resolution becomes better. However, constructing telescopes of ever increasing size is prohibitive for both technical and financial reasons. This problem is solved by using an interferometer which consists of two or more separate telescopes that combine their signals offering a resolution equivalent to the largest separation distance between the telescopes. In this work, the electric field variations from two telescopes will be obtained. The voltage signals from the two telescopes will be coherently combined in order to derive the structure of the target source of radio emission. This combination will be done by a cross-correlator, which multiplies and averages the voltage outputs V1 and V2 of the two dishes. A major challenge to be addressed in this work is to design an instrument capable of making professional-type radio astronomy measurement in a local interference environment. In this regard, the investigative part of this work will verify whether it is possible to achieve a high sensitivity enough to detect some cosmic sources where the presence of man-made interference and cost adversely influences the system. The design of an interferometer will be presented and implemented. It may also serve as a demonstrator for engineering students to gain a working knowledge of radio interferometry.
16Up: Outline of a Study Investigating Wellbeing and Information and Communication Technology Use in Adolescent Twins
Authors: Mitchell Brittany L. , Kirk Katherine M. , McAloney Kerrie , Wright Margaret J. , Davenport Tracey A. , Hermens Daniel F. , Scott James G. , McGrath John J. , Gillespie Nathan A. , Carpenter Joanne S. , O’Callaghan Victoria S. , Medland Sarah , Christensen Helen , Martin Nicholas G. , Burns Jane M. , Hickie Ian B. 
Published: January 2021

AbstractThe ‘16Up’ study conducted at the QIMR Berghofer Medical Research Institute from January 2014 to December 2018 aimed to examine the physical and mental health of young Australian twins aged 16−18 years (N= 876; 371 twin pairs and 18 triplet sets). Measurements included online questionnaires covering physical and mental health as well as information and communication technology (ICT) use, actigraphy, sleep diaries and hair samples to determine cortisol concentrations. Study participants generally rated themselves as being in good physical (79%) and mental (73%) health and reported lower rates of psychological distress and exposure to alcohol, tobacco products or other substances than previously reported for this age group in the Australian population. Daily or near-daily online activity was almost universal among study participants, with no differences noted between males and females in terms of frequency or duration of internet access. Patterns of ICT use in this sample indicated that the respondents were more likely to use online information sources for researching physical health issues than for mental health or substance use issues, and that they generally reported partial levels of satisfaction with the mental health information they found online. This suggests that internet-based mental health resources can be readily accessed by adolescent Australians, and their computer literacy augurs well for future access to online health resources. In combination with other data collected as part of the ongoing Brisbane Longitudinal Twin Study, the 16Up project provides a valuable resource for the longitudinal investigation of genetic and environmental contributions to phenotypic variation in a variety of human traits.
Seed longevity and seedling emergence behavior of wild oat (Avena fatua) and sterile oat (Avena sterilis ssp. ludoviciana) in response to burial depth in eastern Australia
Authors: Mahajan Gulshan , Chauhan Bhagirath S. 
Published: January 2021

AbstractWeed emergence time and the longevity of weed seeds within the soil play an important role in implementing a timely and effective weed control program. In this study, the seed longevity and emergence pattern of wild oat (Avena fatua L.) and sterile oat [Avena sterilis ssp. ludoviciana (Durieu) Gillet & Magne] were monitored in field conditions. Fresh seeds of A. fatua and A. ludoviciana were placed into nylon bags (50 seeds per bag in three replications for three locations in eastern Australia: Gatton, Narrabri, and St George) and buried at depths of 0, 2, and 10 cm in November 2017. Bags were exhumed at 6-mo intervals over 30 mo to evaluate seed germination, viability, and decay components. The seed decay component of A. fatua and A. ludoviciana followed an exponential pattern. On both the surface and at the 10-cm burial depth, 50% of the seeds of A. fatua and A. ludoviciana had decayed by 6 mo. The seeds of A. fatua persisted longer at 2-cm depth than at other depths, particularly at St George, where 90% of the seeds decayed after the 30-mo study. However, at Gatton and Narrabri, 90% of the seeds of A. fatua at this depth had decayed after 18 mo of burial in the soil. In the emergence pattern experiment (2017 to 2019), the emergence of A. fatua and A. ludoviciana from different burial depths was also studied. The emergence of A. fatua and A. ludoviciana was greater from 2-cm (29% to 36%) and 5-cm (18% to 43%) soil depths compared with the surface (5% to 10%) and 10-cm (3-9%) soil depth. Avena ludoviciana emerged earlier (2,253 growing degree days [GDD]; March 14, 2018) than A. fatua (3,364 GDD; May 23, 2018). Both species exhibited high emergence between May to June 2018, and the last cohort of each species was observed in October 2018. The highest seedling emergence occurred at the start of the winter season (May), which emphasizes the need for early PRE weed control such as tillage, herbicide application, and cover crops to ensure crops are planted in a clean seedbed. The continued emergence of these weeds into the spring season (October) emphasizes the need for extended periods of A. fatua and A. ludoviciana management. The results also suggest that management strategies that can control all emerged seedlings over 2 yr and restrict seed rain in the field could lead to complete control of Avena spp. in the field.
Simulating Snow Redistribution and its Effect on Ground Surface Temperature at a High‐Arctic Site on Svalbard
Authors: Zweigel R. B. , Westermann S. , Nitzbon J. , Langer M. , Boike J. , Etzelmüller B. , Vikhamar Schuler T. 
Published: January 2021

AbstractIn high‐latitude and mountain regions, local processes such as redistribution by wind, snow metamorphism, and percolation of water produce a complex spatial distribution of snow depths and snow densities. With its strong control on the ground thermal regime, this snow distribution has pronounced effects on ground temperatures at small spatial scales which are typically not resolved by land surface models (LSMs). This limits our ability to simulate the local impacts of climate change on, for example, vegetation and permafrost. Here, we present a tiling approach combining the CryoGrid permafrost model with snow microphysics parametrizations from the CROCUS snow scheme to account for subgrid lateral exchange of snow and water in a process‐based way. We demonstrate that a simple setup with three coupled tiles, each representing a different snow accumulation class with a specific topographic setting, can reproduce the observed spread of winter‐time ground surface temperatures (GST) and end‐of‐season snow distribution for a high‐Arctic site on Svalbard. For the 3‐year study period, the three‐tile simulations showed substantial improvement compared to traditional single‐tile simulations which naturally cannot account for subgrid variability. Among others, the representation of the warmest and coldest 5% of the observed GST distribution was improved by 1–2°C, while still capturing the average of the distribution. The simulations also reveal positive mean annual GSTs at the locations receiving the greatest snow cover. This could be an indication for the onset of localized permafrost degradation which would be obscured in single‐tile simulations.
Topical lipoic acid choline ester eye drop for improvement of near visual acuity in subjects with presbyopia: a safety and preliminary efficacy trial
Authors: Korenfeld Michael S. , Robertson Stella M. , Stein Jerry M. , Evans David G. , Rauchman Steven H. , Sall Kenneth N. , Venkataraman Subha , Chen Bee-Lian , Wuttke Mark , Burns William 
Published: January 2021

Abstract
Objectives
This study evaluated the safety of topical lipoic acid choline ester (UNR844, 1.5%) ophthalmic solution and its efficacy in improving distance-corrected near visual acuity (DCNVA) in subjects with presbyopia.

Subjects and methods
This was a prospective, randomized, double-masked, and multicentre clinical trial. Subjects with a diagnosis of presbyopia (n = 75) were randomized 2:1 to UNR844 or placebo. On days 1–7, all subjects were dosed unilaterally (twice a day, b.i.d.) in their non-dominant eye to ensure safety and tolerability prior to days 8–91 when dosing was changed to bilateral (b.i.d.). Clinical assessments, including DCNVA and adverse events (AEs), were recorded at each study visit. Patients who completed the study were recruited into a non-interventional follow-up study that monitored them until 7 months after their final UNR844 exposure. The primary endpoints were safety and the mean change in DCNVA from baseline in the study eye.

Results
UNR844 administration (n = 50) produced no safety concerns and was well-tolerated, with no clinically-relevant changes in best-corrected distance visual acuity, pupil size, intraocular pressure, or discontinuations due to adverse events. DCNVA improved in the study eye in the UNR844 group compared to placebo during the 91 days of treatment [UNR844 vs. placebo, mean change in LogMAR (SD); −0.159 (0.120) vs. −0.079 (0.116)]. Bilateral DCNVA improved, with 53.1% UNR844 vs. 21.7% placebo subjects gaining ≥10 letters. Improvements in DCNVA were sustained at 5 and 7 months after UNR844 dosing ceased.

Conclusions
These results support further development of UNR844 ophthalmic solution for the treatment of presbyopia.
Unitary-coupled restricted Boltzmann machine ansatz for quantum simulations
Authors: Hsieh Chang Yu , Sun Qiming , Zhang Shengyu , Lee Chee Kong 
Published: January 2021

AbstractNeural-network quantum state (NQS) has attracted significant interests as a powerful wave-function ansatz to model quantum phenomena. In particular, a variant of NQS based on the restricted Boltzmann machine (RBM) has been adapted to model the ground state of spin lattices and the electronic structures of small molecules in quantum devices. Despite these progresses, significant challenges remain with the RBM-NQS-based quantum simulations. In this work, we present a state-preparation protocol to generate a specific set of complex-valued RBM-NQS, which we name the unitary-coupled RBM-NQS, in quantum circuits. Our proposal expands the applicability of NQS as prior works deal exclusively with real-valued RBM-NQS for quantum algorithms. With this scheme, we achieve (1) modeling complex-valued wave functions, (2) using as few as one ancilla qubit to simulate M hidden spins in an RBM architecture, and (3) avoiding post-selections to improve scalability.
Improvement of gastrointestinal discomfort and inflammatory status by a synbiotic in middle-aged adults: a double-blind randomized placebo-controlled trial
Authors: Neyrinck Audrey M. , Rodriguez Julie , Taminiau Bernard , Amadieu Camille , Herpin Florent , Allaert François-André , Cani Patrice D. , Daube Georges , Bindels Laure B. , Delzenne Nathalie M. 
Published: January 2021

AbstractSeveral studies suggest that microbial alterations (dysbiosis) are intimately linked to chronic inflammation occurring upon aging. The aim of this study was to investigate the potential interest of a synbiotic approach (co-administration of a probiotic bacteria and a prebiotic dietary fibre) to improve gastrointestinal wellness and inflammatory markers in middle-aged people. Middle-aged subjects were randomized to take synbiotic (Bifidobacterium animalis lactis and fructo-oligosaccharides (FOS)) or placebo for 30 days. Stool frequency and consistency were improved in both placebo and synbiotic-treated volunteers while the synbiotic treatment significantly decreased the number of days with abdominal discomfort. Synbiotic treatment had no impact on mood dimensions, quality of life scores or the overall composition of the gut microbiota (16S rRNA gene sequencing of DNA extracted from stool). Importantly, plasma proinflammatory cytokines (interleukin (IL)-6, IL-8, IL-17a and interferon-gamma (IFNγ)) were significantly lower after 30 days of synbiotic supplementation. This effect appears to be independent of the gut barrier function. This study demonstrates that a combination of B. animalis lactis and the well-known prebiotic FOS could be a promising synbiotic strategy to decrease inflammatory status with improvement of gut disorders in middle-aged people.
Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage
Authors: Ait-Ammar Amina , Bellefroid Maxime , Daouad Fadoua , Martinelli Valérie , Van Assche Jeanne , Wallet Clémentine , Rodari Anthony , De Rovere Marco , Fahrenkrog Birthe , Schwartz Christian , Van Lint Carine , Gautier Virginie , Rohr Olivier 
Published: January 2021

AbstractHIV-1 latency generates reservoirs that prevent viral eradication by the current therapies. To find strategies toward an HIV cure, detailed understandings of the molecular mechanisms underlying establishment and persistence of the reservoirs are needed. The cellular transcription factor KAP1 is known as a potent repressor of gene transcription. Here we report that KAP1 represses HIV-1 gene expression in myeloid cells including microglial cells, the major reservoir of the central nervous system. Mechanistically, KAP1 interacts and colocalizes with the viral transactivator Tat to promote its degradation via the proteasome pathway and repress HIV-1 gene expression. In myeloid models of latent HIV-1 infection, the depletion of KAP1 increased viral gene elongation and reactivated HIV-1 expression. Bound to the latent HIV-1 promoter, KAP1 associates and cooperates with CTIP2, a key epigenetic silencer of HIV-1 expression in microglial cells. In addition, Tat and CTIP2 compete for KAP1 binding suggesting a dynamic modulation of the KAP1 cellular partners upon HIV-1 infection. Altogether, our results suggest that KAP1 contributes to the establishment and the persistence of HIV-1 latency in myeloid cells.
Risk of postpolypectomy bleeding in patients taking direct oral anticoagulants or clopidogrel
Authors: Kim Gwang-Un , Lee Sinwon , Choe Jaewon , Hwang Sung Wook , Park Sang Hyoung , Ye Byong Duk , Byeon Jeong-Sik , Myung Seung-Jae , Yang Suk-Kyun , Yang Dong-Hoon 
Published: January 2021

AbstractThe usage of direct oral anticoagulants (DOACs) to prevent and treat thromboembolic events is gradually increasing. We aimed to evaluate the outcomes of patients taking DOACs after polypectomy. We retrospectively reviewed 131 patients taking DOACs and 270 taking clopidogrel who underwent polypectomy between November 2010 and December 2017. The risk of delayed postpolypectomy bleeding (PPB) was evaluated and compared. A total of 989 polyps were removed (320 polyps in the DOAC and 669 polyps in the clopidogrel group). DOACs and clopidogrel were discontinued for 2.8 ± 1.7 days and 5.8 ± 2.5 days before polypectomy, respectively. DOACs and clopidogrel were restarted on 1.6 ± 2.9 days and 1.7 ± 1.1 days after polypectomy, respectively. According to per polyp analysis, delayed PPB rate was 1.6% in both groups (p = 0.924). Logistic regression analysis was performed after propensity score matching and revealed that DOACs did not increase the delayed PPB risk compared to clopidogrel (OR 0.929, 95% CI 0.436–1.975, p = 0.847). With the majority following the antithrombotic discontinuation guidelines, the incidence of delayed PPB was 3.1% in the patients taking DOACs. The delayed PPB risk was not greater in those taking DOACs than in those taking clopidogrel.
Evidence that spillover from Marine Protected Areas benefits the spiny lobster (Panulirus interruptus) fishery in southern California
Authors: Lenihan Hunter S. , Gallagher Jordan P. , Peters Joseph R. , Stier Adrian C. , Hofmeister Jennifer K. K. , Reed Daniel C. 
Published: January 2021

AbstractMarine Protected Areas (MPAs) are designed to enhance biodiversity and ecosystem services. Some MPAs are also established to benefit fisheries through increased egg and larval production, or the spillover of mobile juveniles and adults. Whether spillover influences fishery landings depend on the population status and movement patterns of target species both inside and outside of MPAs, as well as the status of the fishery and behavior of the fleet. We tested whether an increase in the lobster population inside two newly established MPAs influenced local catch, fishing effort, and catch-per-unit-effort (CPUE) within the sustainable California spiny lobster fishery. We found greater build-up of lobsters within MPAs relative to unprotected areas, and greater increases in fishing effort and total lobster catch, but not CPUE, in fishing zones containing MPAs vs. those without MPAs. Our results show that a 35% reduction in fishing area resulting from MPA designation was compensated for by a 225% increase in total catch after 6-years, thus indicating at a local scale that the trade-off of fishing ground for no-fishing zones benefitted the fishery.
Therapie der Weichgewebssarkome inklusive GIST – Update 2021
Authors: Reichardt Peter , Pink Daniel 
Published: January 2021

Was ist neu?
Neoadjuvante und adjuvante Chemotherapie Zur Risikoabschätzung einer perioperativen Chemotherapie kann der „Sarculator“ eingesetzt werden. Unter Einbeziehung von histologischem Subtyp, Tumorgröße, -grading und Patientenalter hilft er, das individuelle Rezidivrisiko zu bestimmen.
Palliative Systemtherapie Zunehmende Hinweise aus Subgruppenanalysen prospektiver Studien und retrospektiven Studien sprechen dafür, dass Patienten mit bestimmten Sarkom-Subtypen auch bezüglich des Gesamtüberlebens von subtypspezifischen Kombinationstherapien schon in der ersten Therapielinie profitieren können. Die Therapieplanung in der metastasierten Situation sollte nicht nur nach patientenindividuellen Gesichtspunkten, sondern auch Sarkom-Subtyp-spezifisch erfolgen.
Gastrointestinaler Stromatumor Mit Avapritinib steht ab sofort eine hochwirksame Therapie für GIST mit der bislang als therapierefraktär angesehenen PDGFRA-Exon-18-D842V-Mutation zur Verfügung. Ripretinib ist eine neue Therapieoption für Patienten, die alle derzeit zugelassenen Substanzen bereits erhalten haben. Durch eine 3-jährige adjuvante Therapie kann bei Patienten mit hohem Rezidivrisiko etwa die Hälfte aller Todesfälle in den ersten 10 Jahren Nachbeobachtung vermieden werden.
Insulin Resistance and Non-Alcoholic Fatty Liver Disease in Premenopausal Women with Metabolic Syndrome
Authors: El-Sehrawy Amr Ali , State Omnia , Elzehery Rasha Rizk , Mohamed Ahmed Salem 
Published: January 2021

AbstractIt is suggested that estrogen protects premenopausal women against non-alcoholic fatty liver disease. From another perspective, the relation between metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD) is bidirectional. Role of insulin resistance (IR) in NAFLD continues to be a matter of debate. The present study aimed to assess the relation between IR and NAFLD in premenopausal women with MetS. The study included 51 premenopausal women with MetS. In addition, there were 40 age-matched healthy controls. All participants were subjected to careful history taking and thorough clinical examination. Performed laboratory investigations included fasting blood glucose, fasting insulin, lipid profile, and liver functions. Calculation of IR was achieved by the Homeostasis Model Assessment (HOMA-IR). NAFLD was graded into three grades according to findings of abdominal ultrasound. Patients had significantly higher BMI, SBP, DBP, FBG, fasting insulin, HOMA-IR, total cholesterol, triglycerides, and LDL levels when compared with controls. They also had significantly lower HDL levels in comparison to controls. Moreover, they have more advanced grades of NAFLD in contrast to controls. Comparison between patients with various grades of NAFLD regarding the clinical data revealed significant increase of fasting insulin and HOMA-IR levels with advancing NAFLD grade. Using multivariate regression analysis, HOMA-IR was an independent predictor of advanced NAFLD grade. In conclusion, the present study documented a combined inter-relation between MetS, IR, and NAFLD in premenopausal women with MetS. IR is correlated with NAFLD grade.
Genetic and Epigenetic Characteristics of Autosomal Dominant Pseudohypoparathyroidism Type 1B: Case Reports and Literature Review
Authors: Luo Dandan , Qi Xiangyu , Liu Luna , Su Yu , Fang Li , Guan Qingbo 
Published: January 2021

AbstractAutosomal dominant pseudohypoparathyroidism 1B (AD-PHP1B) is a rare endocrine and imprinted disorder. The objective of this study is to clarify the imprinted regulation of the guanine nucleotide binding-protein α-stimulating activity polypeptide 1 (GNAS) cluster in the occurrence and development of AD-PHP1B based on animal and clinical patient studies. The methylation-specific multiples ligation-dependent probe amplification (MS-MLPA) was conducted to detect the copy number variation in syntaxin-16 (STX16) gene and methylation status of the GNAS differentially methylated regions (DMRs). Long-range PCR was used to confirm deletion at STX16 gene. In the first family, DNA analysis of the proband and proband’s mother revealed an isolated loss of methylation (LOM) at exon A/B and a 3.0 kb STX16 deletion. The patient’s healthy grandmother had the 3.0 kb STX16 deletion but no epigenetic abnormality. The patient’s healthy maternal aunt showed no genetic or epigenetic abnormality. In the second family, the analysis of long-range PCR revealed the 3.0 kb STX16 deletion for the proband but not her children. In this study, 3.0 kb STX16 deletion causes isolated LOM at exon A/B in two families, which is the most common genetic mutation of AD-PHP1B. The deletion involving NESP55 or AS or genomic rearrangements of GNAS can also result in AD-PHP1B, but it's rare. LOM at exon A/B DMR is prerequisite methylation defect of AD-PHP1B. STX16 and NESP55 directly control the imprinting at exon A/B, while AS controls the imprinting at exon A/B by regulating the transcriptional level of NESP55.