bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is motor inhibition involved in the processing of sentential negation? An assessment via the Stop-Signal Task
Authors: Montalti Martina , Calbi Marta , Cuccio Valentina , Umiltà Maria Alessandra , Gallese Vittorio 
Published: April 2021

AbstractIn the last decades, the embodied approach to cognition and language gained momentum in the scientific debate, leading to evidence in different aspects of language processing. However, while the bodily grounding of concrete concepts seems to be relatively not controversial, abstract aspects, like the negation logical operator, are still today one of the main challenges for this research paradigm. In this framework, the present study has a twofold aim: (1) to assess whether mechanisms for motor inhibition underpin the processing of sentential negation, thus, providing evidence for a bodily grounding of this logic operator, (2) to determine whether the Stop-Signal Task, which has been used to investigate motor inhibition, could represent a good tool to explore this issue. Twenty-three participants were recruited in this experiment. Ten hand-action-related sentences, both in affirmative and negative polarity, were presented on a screen. Participants were instructed to respond as quickly and accurately as possible to the direction of the Go Stimulus (an arrow) and to withhold their response when they heard a sound following the arrow. This paradigm allows estimating the Stop Signal Reaction Time (SSRT), a covert reaction time underlying the inhibitory process. Our results show that the SSRT measured after reading negative sentences are longer than after reading affirmative ones, highlighting the recruitment of inhibitory mechanisms while processing negative sentences. Furthermore, our methodological considerations suggest that the Stop-Signal Task is a good paradigm to assess motor inhibition’s role in the processing of sentence negation.
Pediatric Flexible Endoscopic Evaluation of Swallowing: Critical Analysis of Implementation and Future Perspectives
Authors: Zang Jana , Nienstedt Julie Cläre , Koseki Jana-Christiane , Nießen Almut , Flügel Till , Kim Susan Hyoungeun , Pflug Christina 
Published: April 2021

Abstract
This study aimed to critically review pediatric swallowing assessment data to determine the future need for standardized procedures. A retrospective analysis of 152 swallowing examinations in 128 children aged 21 days to 18 years was performed. The children were presented at a university dysphagia center between January 2015 and June 2020 for flexible-endoscopic evaluation of swallowing (FEES). Descriptive analysis was conducted for the sample, swallowing pathologies, diagnosis, and missing values. Using binary logistic regression, the relationship between dysphagia and underlying diseases was investigated. The largest group with a common diagnosis in the cohort were children with genetic syndromes (n = 43). Sixty-nine children were diagnosed with dysphagia and 59 without dysphagia. The non-dysphagic group included 15 patients with a behavioral feeding disorder. The presence of an underlying disease significantly increased the chance of a swallowing problem (OR 13.08, 95% CI 3.66 to 46.65, p = .00). In particular, the categories genetic syndrome (OR 2.60, 95% CI 1.15 to 5.88) and neurologic disorder (OR 4.23, 95% CI 1.31 to 13.69) were associated with higher odds for dysphagia. All pediatric FEES were performed without complications, with a completion rate of 96.7%, and with a broad variability of implementation. Several charts lacked information concerning swallowing pathologies, though. Generally, a more standardized protocol and documentation for pediatric FEES is needed to enable better comparability of studies on epidemiology, assessment, and treatment outcomes in future.
Nationwide evaluation of mutation-tailored treatment of gastrointestinal stromal tumors in daily clinical practice
Authors: Steeghs Elisabeth M. P. , Gelderblom Hans , Ho Vincent K. Y. , Voorham Quirinus J. M. , Willems Stefan M. ,   PATH consortium, Grünberg Katrien , Ligtenberg Marjolijn J. L. 
Published: April 2021

Abstract
Background
Molecular analysis of KIT and PDGFRA is critical for tyrosine kinase inhibitor treatment selection of gastrointestinal stromal tumors (GISTs) and hence recommended by international guidelines. We performed a nationwide study into the application of predictive mutation testing in GIST patients and its impact on targeted treatment decisions in clinical practice.

Methods
Real-world clinical and pathology information was obtained from GIST patients with initial diagnosis in 2017–2018 through database linkage between the Netherlands Cancer Registry and the nationwide Dutch Pathology Registry.

Results
Predictive mutation analysis was performed in 89% of the patients with high risk or metastatic disease. Molecular testing rates were higher for patients treated in expertise centers (96%) compared to non-expertise centers (75%, P < 0.01). Imatinib therapy was applied in 81% of the patients with high risk or metastatic disease without patient’s refusal or adverse characteristics, e.g., comorbidities or resistance mutations. Mutation analysis that was performed in 97% of these imatinib-treated cases, did not guarantee mutation-tailored treatment: 2% of these patients had the PDGFRA p.D842V resistance mutation and 7% initiated imatinib therapy at the normal instead of high dose despite of having a KIT exon 9 mutation.

Conclusion
In conclusion, nationwide real-world data show that over 81% of the eligible high risk or metastatic disease patients receive targeted therapy, which was tailored to the mutation status as recommended in guidelines in 88% of cases. Therefore, still 27% of these GIST patients misses out on mutation-tailored treatment. The reasons for suboptimal uptake of testing and treatment require further study.
Tick species from cattle in the Adama Region of Ethiopia and pathogens detected
Authors: Tufa Tafese Beyene , Wölfel Silke , Zubriková Dana , Víchová Bronislava , Andersson Martin , Rieß Ramona , Rutaihwa Liliana , Fuchs André , Orth Hans Martin , Häussinger Dieter , Feldt Torsten , Poppert Sven , Dobler Gerhard , Bakkes Deon K. , Chitimia-Dobler Lidia 
Published: April 2021

AbstractTicks will diminish productivity among farm animals and transmit zoonotic diseases. We conducted a study to identify tick species infesting slaughter bulls from Adama City and to screen them for tick-borne pathogens. In 2016, 291 ticks were collected from 37 bulls in Adama, which were ready for slaughter. Ticks were identified morphologically. Total genomic DNA was extracted from ticks and used to test for Rickettsia spp. with real-time PCR. Species identification was done by phylogenetic analysis using sequencing that targeted the 23S-5S intergenic spacer region and ompA genes. Four tick species from two genera, Amblyomma and Rhipicephalus, were identified. Amblyomma cohaerens was the dominant species (n = 241, 82.8%), followed by Amblyomma variegatum (n = 22, 7.5%), Rhipicephalus pulchellus (n = 19, 6.5%), and Rhipicephalus decoloratus (n = 9, 3.0%). Among all ticks, 32 (11%) were positive for Rickettsia spp. and 15 (5.2%) of these were identified as R. africae comprising at least two genetic clades, occurring in A. variegatum (n = 10) and A. cohaerens (n = 5). The remainder of Rickettsia-positive samples could not be amplified due to low DNA yield. Furthermore, another 15 (5.2%) samples carried other pathogenic bacteria: Ehrlichia ruminantium (n = 9; 3.1%) in A. cohaerens, Ehrlichia sp. (n = 3; 1%) in Rh. pulchellus and A. cohaerens, Anaplasma sp. (n = 1; 0.5%) in A. cohaerens, and Neoehrlichia mikurensis (n = 2; 0.7%) in A. cohaerens. All ticks were negative for Bartonella spp., Babesia spp., Theileria spp., and Hepatozoon spp. We reported for the first time E. ruminatium, N. mikurensis, Ehrlichia sp., and Anaplasma sp. in A. cohaerens. Medically and veterinarily important pathogens were mostly detected from A. variegatum and A. cohaerens. These data are relevant for a One-health approach for monitoring and prevention of tick-borne disease transmission.
Chemical weathering and carbon dioxide consumption in a small tropical river catchment, southwestern India
Authors: Nisha Baby Krishnan , Balakrishna Keshava , Udayashankar Harikripa Narayana , Manjunatha Busnur Rachotappa 
Published: April 2021

AbstractStudies done on small tropical west-flowing river catchments located in the Western Ghats in southwestern India have suggested very intense chemical weathering rates and associated CO2 consumption. Very less studies are reported from these catchments notwithstanding their importance as potential sinks of atmospheric CO2 at the global scale. A total of 156 samples were collected from a small river catchment in the southwestern India, the Payaswini–Chandragiri river Basin, during pre-monsoon, monsoon and post-monsoon seasons in 2016 and 2017, respectively. This river system comprises two small rivers originating at an elevation of 1350 m in the Western Ghats in peninsular India. The catchment area is dominated by biotite sillimanite gneiss. Sodium is the dominant cation, contributing ~ 50% of the total cations, whereas HCO3− contributes ~ 75% of total anions. The average anion concentration in the samples varied in the range HCO3− > Cl− > SO42− > NO3− > F−, whereas major cation concentration varied in the range Na+  > Ca2+  > Mg2+  > K+. The average silicate weathering rate (SWR) was 42 t km−2 y−1 in the year 2016 and 36 t km−2 y−1 in 2017. The average annual carbon dioxide consumption rate (CCR) due to silicate rock weathering was 9.6 × 105 mol km−2y−1 and 8.3 × 105 mol km−2 y−1 for 2016 and 2017, respectively. The CCR in the study area is higher than other large tropical river catchments like Amazon, Congo-Zaire, Orinoco, Parana and Indus because of its unique topography, hot and humid climate and intense rainfall.
KDM4B Overexpression Promotes the Growth, Migration, and Invasion of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Activating STAT3 Pathway
Authors: Zhang Xin , Nan He , Guo Jialong , Liu Jinyu 
Published: April 2021

AbstractIn rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) present a unique aggressive phenotype and have a passive response to the inflammatory microenvironment, which are critical for the disease’s progression. KDM4B, as a histone demethylase, functions as an oncogenic factor in many cancers and is implicated in osteoclastogenesis as well as pro-inflammatory cytokine release in inflammatory diseases. However, the effects of KDM4B on RA FLS have not been reported. To investigate this issue, our study determined the expression of KDM4B in RA FLS using RT-qPCR and western blot. The effects of KDM4B on RA FLS viability, apoptosis, migration, and invasion were detected by MTT, flow cytometry, transwell migration, and invasion assays. Furthermore, the interaction of KDM4B with STAT3 signaling was studied by western blot, MTT, flow cytometry, transwell migration, and invasion assays. The experimental results showed that KDM4B expression was upregulated in RA synovial tissues and FLS as compared to healthy control tissues and normal FLS. Knockdown of KDM4B obviously suppressed RA FLS viability, migration and invasion, and induced apoptosis. In addition, knockdown of KDM4B in RA FLS decreased the expression of p-STAT3 and MMP-9 but increased cleaved caspase-3 expression compared with the control group. Moreover, KDM4B overexpression could promote cell growth, migration and invasion, and suppress apoptosis in RA FLS by activating STAT3 signaling. Therefore, these findings provide new insight for understanding the pathogenesis of RA and indicate that KDM4B may have a potential to be an effective therapeutic target for RA.
Living in discarded containers: spiders explore a new niche created by littering in urban woodlands
Authors: Kolenda Krzysztof , Wiśniewski Konrad , Kujawa Krzysztof , Kuśmierek Natalia , Smolis Adrian , Kadej Marcin 
Published: April 2021

AbstractIncreased urbanisation is leading to littering of the environment. However, some animals may adapt to live in such altered habitats. The aim of this study was to assess whether discarded containers can serve as a suitable microhabitat for spiders. The study was conducted in 10 woodland areas in the city of Wrocław, Poland. In September 2018, a total of 939 containers were collected, of which 33.5% contained evidence of spiders having resided therein: webs, dead or living spiders, exuviae or cocoons. A total of 22 species and several other taxa that could not be recognised so accurately were detected. The most common of these belonged to Linyphiidae and Theridiidae. Juveniles (N = 103) dominated over adults (N = 58), and females (N = 34) were more numerous than males (N = 24). In 15 containers, interspecies pairs were found. Among ecological guilds, sheet web spiders dominated (60%) followed by space web spiders (24%), ground hunters (9%), ambush hunters (3%), specialists (3%), and other hunters (2%). Spiders were significantly more often found in colourless (38.3%) and green (35.5%) than in brown bottles (25.2%). They were also more numerous in glass bottles for sweet drinks (50.0%) than in beer bottles (28.0%), and slightly more frequent than in glass vodka bottles (33.3%). Our study showed that discarded containers are fully exploitable microhabitats for spiders and are used by these animals for at least three different purposes: hunting, hiding and breeding, however the effect on their fitness remains unknown.
Land-Use Improvements in the Weather Research and Forecasting Model over Complex Mountainous Terrain and Comparison of Different Grid Sizes
Authors: Golzio Alessio , Ferrarese Silvia , Cassardo Claudio , Diolaiuti Gugliemina Adele , Pelfini Manuela 
Published: April 2021

AbstractWeather forecasts over mountainous terrain are challenging due to the complex topography that is necessarily smoothed by actual local-area models. As complex mountainous territories represent 20% of the Earth’s surface, accurate forecasts and the numerical resolution of the interaction between the surface and the atmospheric boundary layer are crucial. We present an assessment of the Weather Research and Forecasting model with two different grid spacings (1 km and 0.5 km), using two topography datasets (NASA Shuttle Radar Topography Mission and Global Multi-resolution Terrain Elevation Data 2010, digital elevation models) and four land-cover-description datasets (Corine Land Cover, U.S. Geological Survey land-use, MODIS30 and MODIS15, Moderate Resolution Imaging Spectroradiometer land-use). We investigate the Ortles Cevadale region in the Rhaetian Alps (central Italian Alps), focusing on the upper Forni Glacier proglacial area, where a micrometeorological station operated from 28 August to 11 September 2017. The simulation outputs are compared with observations at this micrometeorological station and four other weather stations distributed around the Forni Glacier with respect to the latent heat, sensible heat and ground heat fluxes, mixing-layer height, soil moisture, 2-m air temperature, and 10-m wind speed. The different model runs make it possible to isolate the contributions of land use, topography, grid spacing, and boundary-layer parametrizations. Among the considered factors, land use proves to have the most significant impact on results.
Thermal Submesoscale Motions in the Nocturnal Stable Boundary Layer. Part 1: Detection and Mean Statistics
Authors: Pfister Lena , Lapo Karl , Mahrt Larry , Thomas Christoph K. 
Published: April 2021

AbstractSubmesoscale motions within the stable boundary layer were detected during the Shallow Cold Pool Experiment conducted in the Colorado plains, Colorado, U.S.A. in 2012. The submesoscale motion consisted of two air layers creating a well-defined front with a sharp temperature gradient, and further-on referred to as a thermal submesofront (TSF). The semi-stationary TSFs and their advective velocities are detected and determined by the fibre-optic distributed-sensing (FODS) technique. An objective detection algorithm utilizing FODS measurements is able to detect the TSF boundary, which enables a detailed investigation of its spatio–temporal statistics. The novel approach in data processing is to conditionally average any parameter depending on the distance between a TSF boundary and the measurement location. By doing this, a spatially-distributed feature like TSFs can be characterized by point observations and processes at the TSF boundary can be investigated. At the TSF boundary, the air layers converge, creating an updraft, strong static stability, and vigorous mixing. Further, the TSF advective velocity of TSFs is an order of magnitude lower than the mean wind speed. Despite being gentle, the topography plays an important role in TSF formation. Details on generating mechanisms and implications of TSFs on the stable boundary layer are discussed in Part 2.
Ovarian carcinoma in children with constitutional mutation of SMARCA4: single-family report and literature review
Authors: Pastorczak Agata , Krajewska Karolina , Urbanska Zuzanna , Szmyd Bartosz , Salacinska-Los Elzbieta , Kobos Józef , Mlynarski Wojciech , Trelinska Joanna 
Published: April 2021

AbstractOvarian carcinoma is an extremely rare malignancy in children, often developing on the underlying inherited background. Female carriers of pathogenic germline mutations of SMARCA4 are at risk of an aggressive type of undifferentiated ovarian cancer called small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). Regardless of age of the patient, stage of the disease, and oncological treatment, the prognosis for SCCOHT is poor. Therefore, early intervention with risk-reducing surgeries is recommended for these patients. In this study, we report genetic testing of a family with two children carrying pathogenic germline mutations of SMARCA4 and summarize the course of SCCOHT in all pediatric patients reported in the literature with constitutional defects identified within the SMARCA4 locus.
Material Responses to the Great Depression in Northeast England
Authors: Petts David , O’Donnell Ronan , Armstrong Kayt 
Published: April 2021

AbstractThe Great Depression of the 1920s and 1930s was a global economic crisis, yet to understand its impacts in material terms, it is necessary to recognize that they were situated within specific local and regional contexts. This article, drawing on the work of the Leverhulme Trust-fundedLandscapes of the Great Depression in the North Eastproject, explores the impacts and responses to the Great Depression in Northeast England through an exploration of the materiality of a series of different responses to the crisis, as well as wider consideration of its impact on the landscape. By moving beyond an individual site, and instead looking at a range of interventions at site and landscape scale it shows the potential of taking a more holistic and comparative approach to exploring the impact of the Great Depression and offers an approach that might be used to better understand economic crises in other situations and contexts.
Anti-essentialism, modal relativity, and alternative material-origin counterfactuals
Authors: Janssen-Lauret Frederique 
Published: April 2021

AbstractIn ordinary language, in the medical sciences, and in the overlap between them, we frequently make claims which imply that we might have had different gametic origins from the ones we actually have. Such statements seem intuitively true and coherent. But they counterfactually ascribe different DNA to their referents and therefore contradict material-origin essentialism, which Kripke and his followers argue is intuitively obvious. In this paper I argue, using examples from ordinary language and from philosophy of medicine and bioethics, that statements which attribute alternative material origins to their referents are useful, common in political and medical reasoning, and in many cases best interpreted literally. So we must replace the doctrine of material-origin essentialism with one that can make sense of ordinary discourse and the language of the medical sciences. I propose an anti-essentialist account of such counterfactuals according to which individuals’ modal properties are relative to a given inquiry.
Nomogram to predict the progression of patients with primary membranous nephropathy and nephrotic syndrome
Authors: Liu Lili , Wang Haitao , Zhao Ban , Liu Xin , Sun Ying , Mao Yonghui 
Published: April 2021

Abstract
Background
The outcome of patients with primary membranous nephropathy (pMN) who present with nephrotic syndrome (NS) is variable and difficult to predict. The goal of this study was to develop a nomogram to predict the risk of progression for specific individuals.

Methods
This retrospective study involved biopsy-proven patients with pMN and NS treated between January 2012 and June 2018. The primary outcome of our investigation was progression, defined as a reduction of estimated glomerular filtration rate (eGFR) that was equal to or over 20% compared with baseline at the end of follow-up or the onset of end-stage renal disease (ESRD). We used backwards stepwise logistic regression analysis to create a nomogram to predict prognosis. The model was validated internally using bootstrap resampling.

Results
A total of 111 patients were enrolled. After a median follow-up of 40.0 months (range 12–92 months), 18.9% (21/111) patients showed progression. Backwards stepwise selection using the Akaike information criterion (AIC) identified the following four variables as independent risk factors for progression, which were all used in the nomogram: age ≥ 65 years [odds ratio (OR) 7.004; 95% confidence interval (CI) 1.783–27.505; p = 0.005], Ln (sPLA2R-Ab) (OR 2.150; 95% CI 1.293–3.577; p = 0.003), Ln (proteinuria) (OR 5.939; 95% CI 1.055–33.436; p = 0.043) and Ln (Uα1m/Cr) (OR 2.808; 95% CI 1.035–7.619; p = 0.043). The discriminative ability and calibration of the nomogram revealed good predictive ability, as indicated by a C-index of 0.888 (95% CI 0.814–0.940) and a bootstrap-corrected C-index of 0.869; calibration curves were also well fitted. A receiver operating characteristic (ROC) curve for the nomogram score revealed significantly better discrimination than each of the three risk factors alone, including Ln (sPLA2R-Ab) [area under the curve (AUC) 0.769], Ln (proteinuria) (AUC 0.653) and Ln (Uα1m) (AUC 0.781) in the prediction of progression (p < 0.05). The optimal cutoff value of the nomogram score was 117.8 with a positive predictive value of 44.4% and a negative predictive value of 98.5%.

Conclusion
The nomogram successfully achieved good predictive ability of progression for patients with pMN who present with NS. It can therefore help clinicians to individualize treatment plans and improve the outcome of pMN.