bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interpretable machine learning approach for predicting COVID-19 risk status of an individual
Authors: Onoja Anthony , Ejiwale Mary Oyinlade , Rewane Ayesan 
Published: April 2021

This study aimed to ascertained using Statistical feature selection methods and interpretable Machine learning models, the best features that predict risk status (“Low”, “Medium”, “High”) to COVID-19 infection. This study utilizes a publicly available dataset obtained via; online web-based risk assessment calculator to ascertain the risk status of COVID-19 infection. 57 out of 59 features were first filtered for multicollinearity using the Pearson correlation coefficient and further shrunk to 55 features by the LASSO GLM approach. SMOTE resampling technique was used to incur the problem of imbalanced class distribution. The interpretable ML algorithms were implored during the classification phase. The best classifier predictions were saved as a new instance and perturbed using a single Decision tree classifier. To further build trust and explainability of the best model, the XGBoost classifier was used as a global surrogate model to train predictions of the best model. The XGBoost individual’s explanation was done using the SHAP explainable AI-framework. Random Forest classifier with a validation accuracy score of 96.35 % from 55 features reduced by feature selection emerged as the best classifier model. The decision tree classifier approximated the best classifier correctly with a prediction accuracy score of 92.23 % and Matthew’s correlation coefficient of 0.8960. The XGBoost classifier approximated the best classifier model with a prediction score of 99.7 %. This study identified COVID-19 positive, COVID-19 contacts, COVID-19 symptoms, Health workers, and Public transport count as the five most consistent features that predict an individual’s risk exposure to COVID-19.
Akord à rebours. O muzyce i „duchowej inteligencji” w filmie Interstellar Christophera Nolana
Authors: Lisiecka Katarzyna 
Published: April 2021

The essay aims to reveal the role of music in the movie Interstellar by Christopher Nolan and its significance in creating an artistic message that relates to the love myths characteristic of European culture and art. The orientation point is the Tristanic myth and the project of musical dramaturgy by Richard Wagner, the founder of the concept of music being the significant layer in a Gesamtkunstwerk, a synthesis of the arts, which strongly inspires i.a. cinema. The article ponders possible messages to be decoded from the music in Nolan’s movie: as a “form of a lover’s discourse” (R. Barthes), “significant form” (Suzanne K. Langer), “symbolic form” (E. Cassirer), responsible for shaping the ambience that constitutes an inherent structural part of the movie in the metaphysical cinema genre. The musical solutions applied by Hans Zimmer in the soundtrack to Nolan’s movie do more than merely imply inspiration from Wagner. They also allow for recognition of the polyphonic way of constructing formal and thematic relations between musical themes and the verbal-visual layer of the movie. This refined artistic project aims at a subtly directed confrontation with the nihilistic picture of love that is representative of melancholic-pessimistic images of the condition of human relationships in the modern culture. The analysed main musical theme, called the “à rebours chord” (i.e. anti-Tristan chord), turns out to be an overt musical manifestation of such a counterpunch and becomes a starting point to telling a story that refers to the concept of love which assumes taking action and fighting for the good of your loved ones, as well as the concept of Caritas and unconditional love. The way that the music and sound of the movie are orchestrated is therefore tightly coupled with its semantic and symbolic message, which allows for perceiving the music as a specific “libration point” of the movie structure. Its function might also be interpreted as a semantic attribute of “a spiritual intelligence”, referring to that which is binding and crucial for the axiological and metaphysical message of the movie.
Essential Role of Somatic Kv2 Channels in High-Frequency Firing in Cartwheel Cells of the Dorsal Cochlear Nucleus
Authors: Irie Tomohiko 
Published: April 2021

AbstractAmong all voltage-gated potassium (Kv) channels, Kv2 channels are the most widely expressed in the mammalian brain. However, studying Kv2 in neurons has been challenging because of a lack of high-selective blockers. Recently, a peptide toxin, guangxitoxin-1E (GxTX), has been identified as a specific inhibitor of Kv2, thus facilitating the study of Kv2 in neurons. The mammalian dorsal cochlear nucleus (DCN) integrates auditory and somatosensory information. In the DCN, cartwheel inhibitory interneurons receive excitatory synaptic inputs from parallel fibers conveying somatosensory information. The activation of parallel fibers drives action potentials in the cartwheel cells up to 130 Hzin vivo, and the excitation of cartwheel cells leads to the strong inhibition of principal cells. Therefore, cartwheel cells play crucial roles in monaural sound localization and cancelling detection of self-generated sounds. However, how Kv2 controls the high-frequency firing in cartwheel cells is unknown. In this study, we performed immunofluorescence labeling with anti-Kv2.1 and anti-Kv2.2 antibodies using fixed mouse brainstem slice preparations. The results revealed that Kv2.1 and Kv2.2 were largely present on the cartwheel cell body membrane but not on the axon initial segment (AIS) nor the proximal dendrite. Whole-cell patch-clamp recordings using mouse brainstem slice preparation and GxTX demonstrated that blockade of Kv2 induced failure of parallel fiber-induced action potentials when parallel fibers were stimulated at high frequencies (30–100 Hz). Thus, somatic Kv2 in cartwheel cells regulates the action potentials in a frequency-dependent manner and may play important roles in the DCN function.
EXERGAMING IMPROVES SELF-EFFICACY IN SUSTAINING PHYSICAL ACTIVITY AMONG SEDENTARY UNIVERSITY STUDENTS
Authors: Yusoff Hafzan , Wan Daud Wan Nudri , Rasyad Ahmad Syahmi 
Published: April 2021

This research contrasts the physical activity-related self-efficacy before and after exergame play and the gender-wise expectancy related to beliefs and task values. Sedentary undergraduates (n=102; 51 males, 51 females) were recruited from a local university in Kota Bharu, Kelantan using Global Physical Activity Questionnaire (GPAQ). Participants completed questionnaires assessing their self-efficacy, expectancy related beliefs, subjective task values and intention to participate in exergame play in the future. After exergame play, participants had a significantly higher degree of self-efficacy than before exergame play (mean score: before 27.1 ± 4.33 vs. after 32.2 ± 4.51; p < 0.001). Their belief in their ability to exercise on a regular basis varied considerably across gender, with higher values reported in male than in female participants (mean difference= 0.84, p=0.02). Other components, such as expectancy-related beliefs, task values, and intentions, were comparable between gender. Besides, participants also considered exergaming to be more attractive and stimulating than traditional physical exercise, thereby presenting greater beliefs in capability and greater desire to engage in exergaming in the future. The result suggests that exergame play can be used as an innovative approach to increase the level of physical activity among sedentary university students.
Implications of doping on microstructure, processing, and thermoelectric performance: The case of PbSe
Authors: Grovogui Jann A. , Slade Tyler J. , Hao Shiqiang , Wolverton Christopher , Kanatzidis Mercouri G. , Dravid Vinayak P. 
Published: April 2021

Abstract
In this work, we highlight the often-overlooked effects of doping on the microstructure and performance of bulk thermoelectric materials to offer a broader perspective on how dopants interact with their parent material. Using PbSe doped with Na, Ag, and K as a model material system, we combine original computational, experimental, and microscopy data with established trends in material behavior, to provide an in-depth discussion of the relationship between dopants, processing, and microstructure, and their effects on thermoelectric efficiency and thermal stability. Notable observations include differences in the microstructure and mass loss of thermally treated samples of Na- and Ag-doped PbSe, as well as findings that Na and K cations exist predominantly as substitutional point defects while Ag also occupies interstitial sites and exhibits lower solubility. We discuss how these differences in point defect populations are known to affect a dopants’ ability to alter carrier concentration and how they may affect the mechanical properties of PbSe during processing.

Graphic Abstract
EFFECT OF INTERLEUKINS 2, 7, 15 ON THE PROLIFERATION OF NATURAL KILLERS IN VITRO
Authors: Sitkovskaya A. О. , Zlatnik E. Yu. , Filippova S. Yu. , Bondarenko E. S. , Vaschenko L. N. , Kechedzhieva Е. Е. , Dashkova I. R. , Andreiko E. A. , Novikova I. A. 
Published: April 2021

Introduction.The actual task of modern adoptive cancer immunotherapy is the selection of the optimal composition of cytokines for ex vivo stimulation of immunocompetent cells for subsequent administration to oncological patients.The purpose of the studywas to compare the effect of interleukin (IL) 2, 7, 15 and their combinations on the proliferation of natural killer cells in breast cancer (BC) patients in vitro.Materials and methods.The research was conducted on natural killer cells isolated by magnetic separation from mononuclear cells of peripheral blood of ten patients with locally advanced BC (stage II). After separation, the cells were cultured at a concentration of 2.5 × 105 cells / ml for 10 days in RPMI 1640 medium supplemented with cytokines at a concentration of 40 ng / ml each in five experimental variants: IL‑2; IL‑7; IL‑15; IL‑7 / IL‑15; IL‑2 / IL‑7 / IL‑15. On the 10th day of cultivation, the phenotype of cells and the cell cycle were studied by flow cytometry. For immunophenotyping of cells, we used monoclonal antibodies to antigens: CD3, CD16 / 56, CD45, CD4, CD19, and CD8. For cell cycle study cells were stained with propidium iodide.Results. On the final 10th day of cultivation the number of living cells expressed as percentage of the seeding numbers were significantly different from control (45.9 %) in samples IL‑2 (86.8 %) and IL‑7 / IL‑15 (85.6 %), IL‑15 (76.4 %), IL‑2 / IL‑7 / IL‑15 (75.8 %). The proportion of natural killers (CD16+CD56+) significantly differed from the control (18.2 %) in samples IL‑2 (45.6 %), IL‑15 (39.9 %), IL‑7 / IL‑15 (36.2 %), IL‑2 / IL‑7 / IL‑15 (35.9 %). The propor‑ tion of natural killer T cells (CD3+ / CD16+CD56+) significantly differed from the control (0.4 %) in samples incu‑ bated with IL‑2 (2.06 %), IL‑15 (2.2 %), IL‑7 (0.9 %), IL‑7 / IL‑15 (1.26 %), IL‑2 / IL‑7 / IL‑15 (2.46 %). All experimental tests also showed a significant increase in the proportion of cells in the S‑phase and increase in the proliferation index (G2 / M + S).Conclusion.The maximum stimulation of the proliferation of natural killer cells isolated from the blood of patients with BC in vitro was obtained by stimulation with IL‑15 alone and in combinations with γc‑cytokines.
Estrous Performance of Etawah Crossbred Goats Following Different Estrous Synchronization Methods
Authors: Solihati Nurcholidah , Rasad Siti Darodjah , Winangun Kikin , Toha Toha 
Published: April 2021

The objective of the research was to determine the estrous profile of Etawah Crossbred goats after estrous synchronization with different methods. Eighteen does aged 12-24 month old were divided in three groups to receive estrous synchronization treatments (T1 = 14 days intravaginal implant of 60 mg of progesterone (MPA), T2 = two times injection of 5 mg PGF2α (lutalyse) in 11 days interval, and T3 = 10 days of intravaginal implant of 60 mg of progesterone (MPA) + injection of 5 mg PGF2α 48 hours before removal) with six replications. The parameters consisted of estrous behaviour, changes in size and colour of vulva, and duration of estrus when the number of superficial and keratin cells were dominating in the vaginal mucus cell. Data from estrous behaviour and score of vulvar colour was analyzed using Kurkal Wallis test, while onset of estrus, size of vulva slit and estrous duration was analyzed using ANOVA and Duncan test. The result showed that estrous behaviour and changes in color and size of vulva were not significantly different, but estrous duration was significantly different. Estrous duration in T1 (31.30 hour) and T2 (31.10 hour) was significantly longer than that of T3 (11.36 hour). It is concluded that different methods of estrus synchronization affected estrous quality equally but it affected the estrous duration differently based on vaginal mucus cells. Treatment implant vaginal sponge content progesterone for 14 days and double injection of PGF2α with 11-day interval given longest estrous duration.
Forming Coatings from Self-Fluxing Powder Based on Steels of Austenite Class Adding Molybdenum
Authors: Panteleenko F. I. , Okovity V. A. , Devoino O. G. , Okovity V. V. , Volodko A. S. , Astashinsky V. M. 
Published: April 2021

The paper presents a study of the effect of adding Mo and MoS2 on the microstructure and properties of a powder coating based on austenitic steels. The coatings have been studied using X-ray diffraction (XRD), optical microscopy, scanning electron microscopy (SEM), a Vickers hardness tester, and abrasion wear resistance has been determined by the Pin on disk method. The results show that a coating that does not contain Mo and MoS2 consists of the phases g(Fe), M7(C, B)3 and (Fe, Cr)2B. The addition of Mo and MoS2 leads to the formation of phases M23(C, B)6, Mo2(B, C) and Fe3Mo3(C, B), where M = Fe, Cr, Mo. The main goal of these studies was to study characteristics of Mo and MoS2 distribution and the effect of their addition on the microstructure, hardness, and abrasion wear resistance of an alloy coating based on austenitic steels. Composite materials based on austenitic steels obtained by diffusion alloying (Aus0Mo), which has a nearly spherical shape with a diameter of 50–100 μm, have been used for deposition. 3–7 wt. % of Mo powder and 1.0–1.5 wt. % of MoS2 powder with a diameter less than 50 μm have been added in the powder of the composite material based on austenitic steels (Aus3Mo, Aus5Mo, Aus7Mo). Surfacing methods, including gas arc welding with a tungsten electrode, arc welding in shielding gas, plasma surfacing (PTA) and laser surfacing are widely used in industry to increase wear resistance of surfaces. The most important differences between these methods are deposition rate, applicability of materials, substrate dilution, microstructure and hardness stability after exposure to high temperatures, as well as manufacturing cost. Among the methods described above, plasma spraying followed by fusion is a good alternative to other surfacing processes. The coating should not be overheated until it is completely melted, since in this case the primary crystals of chromium carbides and borides pass into a liquid solution and upon subsequent crystallization, form a coarser structure, worsening the quality of the coating. This is precisely what does not occur during plasma spraying followed by reflow; in addition, the method is cheap, coatings are of high quality, competitive wear resistance and high stability of properties at high temperature.
A Mechanistic Model for Wellbore Cleanout in Horizontal and Inclined Wells
Authors: Elgaddafi Rida , Ahmed Ramadan , Karami Hamidreza , Nasser Mustafa , Hussein Ibnelwaleed 
Published: April 2021

Summary
The accumulation of rock cuttings, proppant, and other solid debris in the wellbore caused by inadequate cleanout remarkably impedes field operations. The cuttings removal process becomes a more challenging task as the coiled-tubing techniques are used during drilling and fracturing operations. This article presents a new hole cleaning model, which calculates the critical transport velocity (CTV) in conventional and fibrous water-based fluids. The study is aimed to establish an accurate mechanistic model for optimizing wellbore cleanout in horizontal and inclined wells.
The new CTV model is established to predict the initiation of bed particle movement during cleanout operations. The model is formulated considering the impact of fiber using a special drag coefficient (i.e., fiber drag coefficient), which represents the mechanical and hydrodynamic actions of suspended fiber particles and their network. The dominant forces acting on a single bed particle are considered to develop the model. Furthermore, to enhance the precision of the model, recently developed hydraulic correlations are used to compute the average bed shear stress, which is required to determine the CTV. In horizontal and highly deviated wells, the wellbore geometry is often eccentric, resulting in the formation of flow stagnant zones that are difficult to clean. The bed shear stress in these zones is sensitive to the bed thickness. The existing wellbore cleanout models do not account for the variation in bed shear stress. Thus, their accuracy is limited when stagnant zones are formed. The new model addresses this problem by incorporating hydraulic correlations to account for bed shear stress variation with bed height.
The accuracy of the new model is validated with published measurements and compared with the precision of an existing model. The use of fiber drag and bed shear stress correlations has improved model accuracy and aided in capturing the contribution of fiber in improving wellbore cleanout. As a result, for fibrous and conventional water-based fluids, the predictions of the new model have demonstrated good agreement with experimental measurements and provided better predictions than the existing model. Model predictions show a noticeable reduction in fluid circulation rate caused by the addition of a small quantity of fiber (0.04% w/w) in the fluid. In addition, results show that the existing model overpredicts the cleaning performance of both conventional and fibrous water-based muds.
Novel Near-Wellbore Fracture Diagnosis for Unconventional Wells Using High-Resolution Distributed Strain Sensing during Production
Authors: Jin G. , Ugueto G. , Wojtaszek M. , Guzik A. , Jurick D. , Kishida K. 
Published: April 2021

SummaryThe characteristics of hydraulic fractures in the near-wellbore region contain critical information related to the production performance of unconventional wells. We demonstrate a novel application of a fiber-optic-based distributed strain sensing (DSS) technology to measure and characterize near-wellbore fractures and perforation cluster efficiency during production. Distributed fiber-optic-based strain measurements are made based on the frequency shift of the Rayleigh scatter spectrum, which is linearly dependent on strain and temperature changes of the sensing fiber. Strain changes along the wellbore are continuously measured during the shut-in and reopening operations of a well. After removing temperature effects, extensional strain changes can be observed at locations around the perforation cluster during a shut-in period. We interpret that the observed strain changes are caused by near-wellbore fracture aperture changes caused by pressure increases within the near-wellbore fracture network. The depth locations of the measured strain changes correlate well with distributed acoustic sensing (DAS) acoustic intensity measurements that were measured during the stimulation of the well. The shape and magnitude of the strain changes differ significantly between two completion designs in the same well. Different dependencies between strain and borehole pressure can be observed at most of the perforation clusters between the shut-in and reopening periods. We assess that this new type of distributed fiber-optic measurement method can significantly improve understanding of near-wellbore hydraulic fracture characteristics and the relationships between stimulation and production from unconventional oil and gas wells.
The Influence of Development Target Depletion on Stress Evolution and Infill Drilling of Upside Target in the Permian Basin
Authors: Pei Yanli , Yu Wei , Sepehrnoori Kamy , Gong Yiwen , Xie Hongbing , Wu Kan 
Published: April 2021

SummaryThe extensive depletion of the development target triggers the demand for infill drilling in the upside target of multilayer unconventional reservoirs. However, such an infill scheme in the field practice still heavily relies on empirical knowledge or pressure responses, and the geomechanics consequences have not been fully understood. Backed by the data set from the Permian Basin, in this work we present a novel integrated reservoir-geomechanics-fracture model to simulate the spatiotemporal stress evolution and locate the optimal development strategy in the upside target of the Bone Spring Formation. An embedded discrete fracture model (EDFM) is deployed in our fluid-flow simulation to characterize complex fractures, and the stress-dependent matrix permeability and fracture conductivity are included through the compaction/dilation option. After calibrating reservoir and fracture properties by history matching of an actual well in the development target (i.e., third Bone Spring), we run the finite element method (FEM)-based geomechanics simulation to model the 3D stress state evolution. Then a displacement discontinuity method (DDM) hydraulic fracture model is applied to simulate the multicluster fracture propagation under an updated heterogeneous stress field in the upside target (i.e., second Bone Spring). Numerical results indicate that stress field redistribution associated with parent-well production indeed vertically propagates to the upside target. The extent of stress reorientation at the infill location mainly depends on the parent-child horizontal offset, whereas the stress depletion is under the combined impact of horizontal offset, vertical offset, and infill time. A smaller parent-child horizontal offset aggravates the overlap of the stimulated reservoir volume (SRV), resulting in more substantial interwell interference and less desirable oil and gas production. The same trend is observed by varying the parent-child vertical offset. Moreover, the efficacy of an infill operation at an earlier time is less affected by parent-well depletion because of the less-disturbed stress state. The candidate infill-well locations at various infill timings are suggested based on the parent-well and child-well production cosimulation. Being able to incorporate both pressure and stress responses, the reservoir-geomechanics-fracture model delivers a more comprehensive understanding and a more integral solution of infill-well design in multilayer unconventional reservoirs. The conclusions provide practical guidelines for the subsequent development in the Permian Basin.