bluuebunny/crossref_metadata_2025_split huggingface dataset:
Major environmental factors and traits of invasive alien plants determine their spatial distribution: a case study in Korea
Authors: Oh Minwoo , Heo Yoonjeong , Lee Eun Ju , Lee Hyohyemi 
Published: October 2021

Abstract
Background
As trade increases, the influx of various alien species and their spread to new regions are prevalent, making them a general problem globally. Anthropogenic activities and climate change have led to alien species becoming distributed beyond their native range. As a result, alien species can be easily found anywhere, with the density of individuals varying across locations. The prevalent distribution of alien species adversely affects invaded ecosystems; thus, strategic management plans must be established to control them effectively. To this end, this study evaluated hotspots and cold-spots in the degree of distribution of invasive alien plant species, and major environmental factors related to hot spots were identified. We analyzed 10,287 distribution points of 126 species of alien plant species collected through a national survey of alien species using the hierarchical model of species communities (HMSC) framework.

Results
The explanatory and fourfold cross-validation predictive power of the model were 0.91 and 0.75 as area under the curve (AUC) values, respectively. Hotspots of invasive plants were found in the Seoul metropolitan area, Daegu metropolitan city, Chungcheongbuk-do Province, southwest shore, and Jeju Island. Hotspots were generally found where the highest maximum summer temperature, winter precipitation, and road density were observed. In contrast, seasonality in temperature, annual temperature range, precipitation during summer, and distance to rivers and the sea were negatively correlated to hotspots. The model showed that functional traits accounted for 55% of the variance explained by environmental factors. Species with a higher specific leaf area were found where temperature seasonality was low. Taller species were associated with a larger annual temperature range. Heavier seed mass was associated with a maximum summer temperature > 29 °C.

Conclusions
This study showed that hotspots contained 2.1 times more alien plants on average than cold-spots. Hotspots of invasive plants tended to appear under less stressful climate conditions, such as low fluctuations in temperature and precipitation. In addition, disturbance by anthropogenic factors and water flow positively affected hotspots. These results were consistent with previous reports on the ruderal and competitive strategies of invasive plants, not the stress-tolerant strategy. Our results supported that the functional traits of alien plants are closely related to the ecological strategies of plants by shaping the response of species to various environmental filters. Therefore, to control alien plants effectively, the occurrence of disturbed sites where alien plants can grow in large quantities should be minimized, and the waterfront of rivers must be managed.
The impact of COVID-19 on self-management behaviours and healthcare access for people with inflammatory arthritis
Authors: Caton Emma , Chaplin Hema , Carpenter Lewis , Sweeney Melissa , Tung Hsiu Yen , de Souza Savia , Galloway James , Nikiphorou Elena , Norton Sam 
Published: October 2021

AbstractBackgroundInflammatory arthritis (IA) patients have been identified as at greater risk of severe illness from COVID-19. It is likely that lockdown restrictions (enforced by the UK government in response to the COVID-19 pandemic) and subsequent changes made to healthcare provision could impact patients’ abilities to effectively manage their condition. The aim of this study was to qualitatively explore the impact of COVID-19 on self-management behaviours and healthcare access for people with IA.MethodsSemi-structured interviews were conducted with 21 IA patients in June-July 2020, with nine follow-up interviews in November 2020. Interview schedules were developed with a Patient Research Partner and explored participants’ experiences of the COVID-19 pandemic. Interviews were conducted via telephone and analysed using inductive thematic analysis.ResultsParticipants were aged between 24 and 79 years (mean = 50.1, SD = 15.8), largely female (71%) and White British (86%). Four initial themes were identified: (1) Impact of COVID-19 on medication adherence, (2) Impact of COVID-19 on physical activity, (3) Impact of COVID-19 on diet, and (4) Impact of COVID-19 on healthcare access and delivery. Subthemes focused on positive and negative changes made to these areas, as well as behaviours which remained consistent. Follow-up interviews highlighted differences in participants’ experiences during the two lockdown periods.ConclusionCOVID-19 has affected patients’ abilities to manage their IA. Healthcare professionals need to recognise the ongoing impact of COVID-19 on patient self-management and healthcare access to ensure that adequate understanding and support is available to patients who may have inadequate disease control as a result.
Cervical osteomyelitis and an epidural abscess: an unusual form of cat-scratch disease in one case
Authors: Khay Hamid , Chibbaro Salvatore , Dehneh Younes , Cebula Helene , Proust François 
Published: October 2021

Abstract
Background
The association of cervical osteomyelitis with epidural abscess is extremely rare; atypical symptomatology is what makes diagnosing and management challenging. This case is the sixth case reported in the literature. The objective of our study is to describe the clinical manifestation and treatment approach.

Case presentation
A 71-year-old male with no medical history, who was admitted to the emergency room for C7-T1 spinal cord compression caused by Bartonella henselae, marked improvement after decompression by evacuating the empyema and antibiotic course.

Conclusion
Cat-scratch disease or subacute regional lymphadenitis is a bacterial infection caused by Bartonella henselae; children and adolescents are mostly infected. Systemic complications are rare; the prevalence of bone damage is estimated at 0.1 to 0.3%. Our case allows a literature review of and put in focus on our diagnostic and therapeutic attitude.
Metabolic and functional imaging employment in the differentiation of brown tumors from bone metastases in a case of primary papillary thyroid cancer and parathyroid adenoma: case report
Authors: Al-Rasheed Ula , Barakat Fareed , Al-Ibraheem Akram 
Published: October 2021

AbstractBackgroundBrown tumors are benign osteoclastic bone lesions encountered in patients with hyperparathyroidism. These tumors may demonstrate aggressive, destructive features in the skeleton and imitate metastatic bone lesions, particularly in patients with known primary neoplasm. In this case report of recurrent papillary thyroid cancer and ectopic parathyroid adenoma, we shed light on the importance of combining different nuclear medicine imaging modalities to differentiate brown tumors from metastatic bone lesions.Case presentationWe present a 39-year-old woman with a known history of papillary thyroid carcinoma classic type stage pT1N1b post-total thyroidectomy and radioactive iodine (I-131) therapy (RAI) presented with upper limb weakness and pain. An expansile lytic lesion involving the 6th cervical vertebra was seen in cervical spine MRI, which was suspicious for metastatic deposit. Therapeutic and diagnostic I-131 whole-body scans were negative for any I-13-avid lesions. Laboratory results revealed high calcium, parathyroid hormone, and alkaline phosphatase. A Technetium-99m-sestamibi (Tc-99m MIBI) scan was done with the standard protocol of spot views to the neck and upper chest area to localize any suspicious parathyroid adenoma. The scan demonstrated right supraclavicular and mediastinal Tc-99m MIBI-avid lesions suspicious for being ectopic parathyroid adenomas. Whole-body fluorine-18-2-fluoro-2-deoxy-d-glucose (18F-FDG), positron emission tomography/computed tomography (PET/CT) (18F-FDG PET/CT) was performed for further evaluation. It demonstrated multiple focal lytic skeletal lesions of abnormal increased FDG uptake as well as right supraclavicular FDG-avid lymph nodes. However, the superior mediastinal lesion was non-FDG-avid, suggesting the existence of two different entities: ectopic parathyroid adenoma with multiple brown tumors and metastatic right supraclavicular lymph nodes. The patient underwent right neck dissection and superior mediastinal mass excision. An intra-operative fresh serum parathyroid sample was sent, which dropped down to 100ng/ml from 863.7ng/ml. Later, histopathological results revealed that the right supraclavicular lymph nodes were metastatic papillary thyroid carcinoma. At the same time, the superior mediastinal mass proved to be parathyroid adenoma by histopathology, confirming the18F-FDG PET/CT findings.ConclusionsIn the case of papillary thyroid carcinoma, metastatic lymph nodes with hyperparathyroidism, and evidence of lytic bone lesions, careful interpretation of the different metabolic and functional imaging modalities are needed to exclude the concurrent parathyroid adenoma and facilitate the differentiation of brown tumors from bone metastases, leading to appropriate surgical and medical treatment plans.
Hypoalbuminemia linked to myocardial dysfunction in recent-onset nephrotic syndrome: a cross-sectional case control 3DSTE study
Authors: AbdelMassih Antoine , Haroun Mervat , Samir Mohamed , Younis Samar , Tamer Martina , Salem Amr 
Published: October 2021

Abstract
Background
Although myocardial dysfunction in the context of longstanding steroid-resistant nephrotic syndrome (NS) has been the focus of many series, the detection of myocardial involvement in recent-onset NS has not taken sufficient attention. The primary outcome parameter of our study is the detection of myocardial dysfunction in the initial episode of NS (first 4 weeks after the onset), while the secondary outcome parameter is the determination of the best predictor of such dysfunction among systolic blood pressure, diastolic blood pressure, the duration of the initial episode of NS, and biochemical parameters such as serum albumin and cholesterol.

Methods
Forty NS patients during the initial episode of NS (first 4 weeks from the onset) were examined for anthropometric data as well as for serum albumin and cholesterol. Motion-mode echocardiography was used to determine Fractional shortening, while 3D echocardiography was applied to determine left ventricular (LV) ejection fraction (EF) and GLS (global longitudinal strain). Finally, we employed combined conventional and tissue doppler to determine LV E/e′ ratio (ratio of early transmitral inflow and average early diastolic basal septal and mitral annular velocities). Forty healthy, age- and sex-matched controls were enrolled to control advanced echocardiographic parameters.

Results
LV GLS was markedly reduced in cases compared to controls, denoting subtle systolic dysfunction, while, LV E/e′ ratio was significantly higher in cases denoting diastolic dysfunction in early NS. Hypoalbuminemia was found to be the best predictor of both LV GLS and LV E/e′ ratio.

Conclusion
Myocardial dysfunction should be considered in any NS patient even in recent-onset NS, the severity of hypoalbuminemia seems to be the best determinant of this dysfunction either by increasing endothelial dysfunction or through triggering inflammation. Further studies are needed on the mechanism by which hypoalbuminemia induces myocardial dysfunction in NS patients
Musculoskeletal Features in Adults With X-linked Hypophosphatemia: An Analysis of Clinical Trial and Survey Data
Authors: Javaid Muhammad Kassim , Ward Leanne , Pinedo-Villanueva Rafael , Rylands Angela J , Williams Angela , Insogna Karl , Imel Erik A 
Published: October 2021

Abstract

Context
Patients with X-linked hypophosphatemia (XLH) experience multiple musculoskeletal manifestations throughout adulthood.

Objective
To describe the burden of musculoskeletal features and associated surgeries across the lifespan of adults with XLH.

Methods
Three groups of adults were analyzed: subjects of a clinical trial, participants in an online survey, and a subgroup of the online survey participants considered comparable to the clinical trial subjects (according to Brief Pain Inventory worst pain scores of ≥ 4). In each group, the adults were categorized by age: 18-29, 30-39, 40-49, 50-59, and ≥ 60 years. Rates of 5 prespecified musculoskeletal features and associated surgeries were investigated across these age bands for the 3 groups.

Results
Data from 336 adults were analyzed. In all 3 groups, 43% to 47% had a history of fracture, with the proportions increasing with age. The overall prevalence of osteoarthritis was &gt; 50% in all 3 groups, with a rate of 23% to 37% in the 18- to 29-year-old group, and increasing with age. Similar patterns were observed for osteophytes and enthesopathy. Hip and knee arthroplasty was reported even in adults in their 30s. Spinal stenosis was present at a low prevalence, increasing with age. The proportion of adults with ≥ 2 musculoskeletal features was 59.1%, 55.0%, and 61.3% in the clinical trial group, survey group, and survey pain subgroup, respectively.

Conclusion
This analysis confirmed high rates of multiple musculoskeletal features beginning as early as age 20 years among adults with XLH and gradually accumulating with age.
Spinal Neuronal GRK2 Contributes to Preventive Effect by Electroacupuncture on Cisplatin-Induced Peripheral Neuropathy in Mice
Authors: Ma Xue , Chen Yu , Li Xiao-Chen , Mi Wen-Li , Chu Yu-Xia , Wang Yan-Qing , Mao-Ying Qi-Liang 
Published: October 2021

BACKGROUND:
The main symptoms of chemotherapy-induced peripheral neuropathy (CIPN) include pain and numbness. Neuronal G protein–coupled receptor kinase 2 (GRK2) plays an important role in various pain models. Cisplatin treatment can induce the activation of proinflammatory microglia in spinal cord. The purpose of this study was to investigate the role of spinal neuronal GRK2 in cisplatin-induced CIPN and in the prevention of CIPN by electroacupuncture (EA).

METHODS:
The pain and sensory deficit behaviors of mice were examined by von Frey test and adhesive removal test. The expression of neuronal GRK2 in the spinal cord is regulated by intraspinal injection of adeno-associated virus (AAV) containing neuron-specific promoters. The protein levels of GRK2, triggering receptor expressed on myeloid cells 2 (TREM2), and DNAX-activating protein of 12 kDa (DAP12) in spinal dorsal horn were detected by Western blot, the density of intraepidermal nerve fibers (IENFs) was detected by immunofluorescence, and microglia activation were evaluated by real-time polymerase chain reaction (PCR).

RESULTS:
In this study, cisplatin treatment led to the decrease of GRK2 expression in the dorsal horn of spinal cord. Overexpression of neuronal GRK2 in spinal cord by intraspinal injection of an AAV vector expressing GRK2 with human synapsin (hSyn) promotor significantly inhibited the loss of IENFs and alleviated the mechanical pain and sensory deficits induced by cisplatin. Real-time PCR analysis showed that the overexpression of neuronal GRK2 significantly inhibited the messenger RNA (mRNA) upregulation of proinflammatory cytokine interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), and M1 microglia marker cluster of differentiation (CD)16 induced by cisplatin. Furthermore, the TREM2 and DAP12, which has been demonstrated to play a role in microglia activation and in the development of CIPN, were also downregulated by overexpression of neuronal GRK2 in this study. Interestingly, preventive treatment with EA completely mimics the effect of overexpression of neuronal GRK2 in the spinal cord in this mouse model of cisplatin-induced CIPN. EA increased GRK2 level in spinal dorsal horn after cisplatin treatment. Intraspinal injection of AAV vector specifically downregulated neuronal GRK2, completely reversed the regulatory effect of EA on CIPN and microglia activation. All these indicated that the neuronal GRK2 mediated microglial activation contributed to the process of CIPN.

CONCLUSIONS:
Neuronal GRK2 in the spinal cord contributed to the preventive effect of EA on CIPN. The neuronal GRK2 may be a potential target for CIPN intervention.
On Crystallization
Authors: Marriott David 
Published: October 2021

AbstractThis essay considers the various meanings of the word “crystallization” in Frantz Fanon's main theses on national culture and his political philosophy more generally. It also further considers the implications of crystallization alongside Fanon's notion of the “nation to come” for an understanding of his approach to art, history, philosophy, and religion. This philosophy of crystallization, of which there has been little or no mention in Fanonian studies, is also contrasted with and compared to works by the Guinean poet Keita Fodéba and the Iranian critic Ali Shariʿati.
The Value of the Surface
Authors: Hyvönen Ari-Elmeri 
Published: October 2021

AbstractThrough an unorthodox reading of Hannah Arendt, this article argues that her political thought contains unacknowledged resources for conceptualizing embodiment in politics, and in relation to the economy, physical needs, and appearance. In contrast to the way she is typically read, this essay develops an affirmative account of embodiment in Arendt's work. Arendt not only recognizes the role of the appearing body in action but also underscores the importance of labor and necessity for a human sense of reality. Throughout her oeuvre, she presents a historical analysis of the rise of a functionalist, processual understanding of life under capitalist modernity. She also develops an alternative, nonfunctionalist framing of living bodies, highlighting a gratitude for “given” aspects of existence and the value of the bodily surface as a sentient interface between embodied needs and the common world. The article tracks the development of these reflections in Arendt's engagements with Karl Marx, Simone Weil, and Adolf Portmann.
Effects of Weather Parameters on Endurance Running Performance: Discipline-specific Analysis of 1258 Races
Authors: MANTZIOS KONSTANTINOS , IOANNOU LEONIDAS G. , PANAGIOTAKI ZOE , ZIAKA STYLIANI , PÉRIARD JULIEN D. , RACINAIS SÉBASTIEN , NYBO LARS , FLOURIS ANDREAS D. 
Published: October 2021

ABSTRACT

Introduction
This study evaluated how single or combinations of weather parameters (temperature, humidity, wind speed, and solar load) affect peak performance during endurance running events and identified which events are most vulnerable to varying weather conditions.

Methods
Results for the marathon, 50-km racewalking, 20-km racewalking, and 10,000-, 5000-, and 3000-m steeplechase were obtained from the official Web sites of large competitions. We identified meteorological data from nearby (8.9 ± 9.3 km) weather stations for 1258 races held between 1936 and 2019 across 42 countries, enabling analysis of 7867 athletes.

Results
The wet bulb globe temperature (WBGT) across races ranged from −7°C to 33°C, with 27% of races taking place in cold/cool, 47% in neutral, 18% in moderate heat, 7% in high heat, and 1% in extreme heat conditions, according to the World Athletics classification. Machine learning decision trees (R
2 = 0.21–0.58) showed that air temperature (importance score = 40%) was the most important weather parameter. However, when used alone, air temperature had lower predictive power (R
2 = 0.04–0.34) than WBGT (R
2 = 0.11–0.47). Conditions of 7.5°C–15°C WBGT (or 10°C–17.5°C air temperature) increased the likelihood for peak performance. For every degree WBGT outside these optimum conditions, performance declined by 0.3%–0.4%.

Conclusion
More than one-quarter of endurance running events were held in moderate, high, or extreme heat, and this number reached one-half when marathons were excluded. All four weather parameters should be evaluated when aiming to mitigate the health and performance implications of exercising at high intensities in a hot environment with athletes adopting heat mitigation strategies when possible.
Fitness Level‐ and Sex-Related Differences in Macrovascular and Microvascular Responses during Reactive Hyperemia
Authors: RASICA LETIZIA , INGLIS ERIN CALAINE , IANNETTA DANILO , SOARES ROGERIO N. , MURIAS JUAN M. 
Published: October 2021

ABSTRACT

Purpose
Reactive hyperemia (RH) is widely used for the investigation of macrovascular (flow-mediated dilation, or FMD) and microvascular (near-infrared spectroscopy–vascular occlusion test, or NIRS-VOT) function. Mixed results have been reported on fitness level‐ and sex-related differences in FMD outcomes, and little is known about microvascular differences in untrained and chronically trained males and females.

Methods
Fifteen chronically trained (CT: 8 males, 7 females) and 16 untrained (UT: 8 males, 8 females) individuals participated in this study. Aerobic fitness (V˙O2max) was assessed during a cycling incremental exercise test to volitional exhaustion. FMD and NIRS-VOT were performed simultaneously on the lower limb investigating superficial femoral artery and vastus lateralis muscle, respectively.

Results
%FMD was not different between groups (CT males, 4.62 ± 1.42; CT females, 4.15 ± 2.23; UT males, 5.10 ± 2.53; CT females, 3.20 ± 1.67). Peak blood flow showed greater values in CT versus UT (P ≤ 0.0001) and males versus females (P = 0.032). RH blood flow area under the curve was greater in CT versus UT (P = 0.001). At the microvascular level, desaturation and reperfusion rates were faster in CT versus UT (P = 0.018 and P = 0.013) and males versus females (P = 0.011 and P = 0.005). V˙O2max was significantly correlated with reperfusion rate (P = 0.0005) but not with %FMD.

Conclusions
Whereas NIRS-VOT outcomes identified fitness- and sex-related differences in vascular responses, %FMD did not. However, when RH-related outcomes from the FMD analysis were considered, fitness- and/or sex-related differences were detected. These data highlight the importance of integrating FMD and NIRS-VOT outcomes for a more comprehensive evaluation of vascular function.