bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mantle cell lymphoma treatment options for elderly/unfit patients: A systematic review
Authors: Alnassfan Tahera , Cox‐Pridmore Megan J. , Taktak Azzam , Till Kathleen J 
Published: November 2021

AbstractMantle cell lymphoma (MCL) is a rare B‐cell non‐Hodgkin lymphoma (NHL) that is aggressive and incurable with existing therapies, presenting a significant unmet clinical need. MCL occurs mainly in elderly patients with comorbidities; thus, intense treatment options including allogeneic stem cell transplantation (Allo‐SCT) are not feasible. New treatment options are emerging for this elderly/unfit treatment group, we therefore conducted a systematic review to determine whether they offered an advance on the existing recommended treatment, R‐CHOP. The search strategies to identify MCL therapies were designed to capture the most relevant studies from 2013 to 2020. Following preferred reporting items for systematic reviews and meta‐analyses and population,interventions, observations and study design analysis, R‐CHOP, ibrutinib and bendamustine plus rituximab (BR) were taken forward for critical and statistical analysis. All three therapies were effective in increasing the overall survival (OS) and progression‐free survival of elderly/unfit patients with MCL. However, none resulted in a significant increase in OS compared to R‐CHOP. In addition, R‐CHOP had a better toxicity profile when compared to both ibrutinib and BR. We therefore conclude that treatment of elderly/unfit patients with MCL is still a significant unmet clinical need; and suggest that outside of the clinical trial setting, R‐CHOP should remain the recommended front‐line treatment for this patient group.
Effects of Texture Density on the Tribological Properties of Plasma Electrolytic Oxidation/Polytetrafluoroethylene Coatings Formed on Aluminum Alloys
Authors: Lu Cheng , Ding Jinhua , Shi Peiying , Jia Junhong , Xie Erqing , Sun Yuan 
Published: November 2021

AbstractPlasma electrolytic oxidation (PEO) coatings are commonly used as protective materials in the automotive industry. In this study, textured PEO coatings with different densities of dimples are fabricated by laser surface texturing, which is followed by coating with self‐lubricating polytetrafluoroethylene (PTFE) material by vacuum penetration. The topographies, microstructures, and tribological properties of the textured PEO/PTFE coatings are investigated. The results show that the texture densities have a significant effect on the tribological properties of composite PEO/PTFE coatings. The composite coating with a texture density of 39.7% shows a stable and low friction coefficient of ≈0.11 under test loads ranging from 5 to 20 N. In addition, this coating exhibits better carrying capacity than other textured coatings during the friction process. With the increase in dimple area density, the storage capacity of the composite coating increases, and is accompanied by a decreased load‐bearing capacity. This leads to further contact with the friction interface, which is beneficial to lubrication. An ideal balance between the physical support of the PEO coating and the lubricating effect of the PTFE film is achieved.
Complex B1+ mapping with Carr‐Purcell spin echoes and its application to electrical properties tomography
Authors: Iyyakkunnel Santhosh , Weigel Matthias , Ganter Carl , Bieri Oliver 
Published: November 2021

PurposeTo present a new complex‐valued B1+ mapping method for electrical properties tomography using Carr‐Purcell spin echoes.MethodsA Carr‐Purcell (CP) echo train generates pronounced flip‐angle dependent oscillations that can be used to estimate the magnitude of B1+. To this end, a dictionary is used that takes into account the slice profile as well as T2 relaxation along the echo train. For validation, the retrieved B1+ map is compared with the actual flip angle imaging (AFI) method in a phantom (79 ε0, 0.34 S/m). Moreover, the phase of the first echo reflects the transceive phase. Overall, the CP echo train yields an estimate of the complex‐valued B1+, allowing electrical properties tomography with both permittivity and conductivity. The presented method is evaluated in phantom scans as well as for in vivo brain at 3 T.ResultsIn the phantom, the obtained magnitude B1+ maps retrieved from the CP echo train and the AFI method show excellent agreement, and both the reconstructed estimated permittivity (79 ± 3) ε0 and conductivity (0.35 ± 0.04) S/m values are in accordance with expectations. In the brain, the obtained electrical properties are also close to expectations. In addition to the retrieved complex B1+ information, the decay of the CP echo trains also yields an estimate for T2.ConclusionThe CP sequence can be used to simultaneously provide both B1+ magnitude and phase estimations, and therefore allows for full reconstruction of the electrical properties.
Sensitivity schemes for dynamic glucose‐enhanced magnetic resonance imaging to detect glucose uptake and clearance in mouse brain at 3 T
Authors: Huang Jianpan , Lai Joseph H. C. , Han Xiongqi , Chen Zilin , Xiao Peng , Liu Yang , Chen Lin , Xu Jiadi , Chan Kannie W. Y. 
Published: November 2021

We investigated three dynamic glucose‐enhanced (DGE) MRI methods for sensitively monitoring glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF) at clinical field strength (3 T). By comparing three sequences, namely, Carr–Purcell–Meiboom–Gill (CPMG), on‐resonance variable delay multipulse (onVDMP), and on‐resonance spin‐lock (onSL), a high‐sensitivity DGE MRI scheme with truncated multilinear singular value decomposition (MLSVD) denoising was proposed. The CPMG method showed the highest sensitivity in detecting the parenchymal DGE signal among the three methods, while both onVDMP and onSL were more robust for CSF DGE imaging. Here, onVDMP was applied for CSF imaging, as it displayed the best stability of the DGE results in this study. The truncated MLSVD denoising method was incorporated to further improve the sensitivity. The proposed DGE MRI scheme was examined in mouse brain with 50%/25%/12.5% w/w D‐glucose injections. The results showed that this combination could detect DGE signal changes from the brain parenchyma and CSF with as low as a 12.5% w/w D‐glucose injection. The proposed DGE MRI schemes could sensitively detect the glucose signal change from brain parenchyma and CSF after D‐glucose injection at a clinically relevant concentration, demonstrating high potential for clinical translation.
Altering sorption and diffusion coefficients of gases in 6FDA‐based membrane via addition of functionalized Ti‐based fillers
Authors: Suhaimi Nadia Hartini , Yeong Yin Fong , Jusoh Norwahyu , Chew Thiam Leng , Bustam Mohamad Azmi , Mubashir Muhammad 
Published: November 2021

AbstractIn this work, we systematically investigate and analyze the transport properties including carbon dioxide and methane gases, as well as carbon dioxide induced‐plasticization behavior over 6FDA‐based mixed matrix filled with nonfunctionalized and amine‐functionalized MIL‐125 (Ti) particles. First, the sorption behavior and permeability of CO2 and CH4 gases across the membranes were evaluated experimentally. Then, the dual‐mode sorption model was used to determine the gas solubility coefficients of gases, whereas the partial immobilization model was used to quantify the diffusivity coefficients of gases. From the results obtained, the permeability of CO2 and the ideal selectivity of CO2/CH4 increased 86%–118% upon the addition of nonfunctionalized and amine‐functionalized MIL‐125 (Ti) fillers into 6FDA/durene polymer. Such increment was mainly attributed to the altered sorption and diffusion properties of the membrane after incorporating the fillers that promoted the transport of CO2 through the membrane. The coefficients of Langmuir sorption capacity (C′H), Henry's law (KD), and affinity constant (b) obtained for NH2‐MIL‐125 (Ti)/6FDA‐durene increased 35.5%, 179.8%, and 104.4%, respectively, compared to pure 6FDA‐durene membrane. Besides, NH2‐MIL‐125 (Ti)/6FDA‐durene mixed matrix membrane showed the highest diffusivity coefficient of 35.1 × 10−8 cm2/s, resulting in higher CO2/CH4 selectivity of 37.1. In addition, the CO2 plasticization resistance obtained for nonfunctionalized and amine‐functionalized mixed matrix membrane was also improved about 150%–200% compared to pure 6FDA‐durene membrane. Overall, this study revealed that the inclusion of fillers into the polymer matrix has resulted in higher membrane performance than the neat membrane, which associated with the increased of both diffusivity and solubility of CO2. Thus, the incorporation of fillers into polymer matrix has altered the gas transport behavior, and this study could provide basic information on gas transport properties in analyzing the gas separation performance of 6FDA‐based mixed matrix membranes.
Bayesian inference for modified Weibull distribution under simple step‐stress model based on type‐I censoring
Authors: Ramzan Qasim , Amin Muhammad , Faisal Muhammad 
Published: November 2021

AbstractIn this paper, we consider a simple step‐stress accelerated life test (SSALT) model under the tampered random variable (TRV) model for the modified Weibull distribution (MWD) with type‐I censoring. We consider the classical and Bayesian estimation methods for the estimation of unknown parameters of the MWD model. In the classical scenario, we derive the maximum likelihood estimates (MLEs) and approximate confidence intervals (ACIs) for model parameters. Also, a parametric bootstrap resampling technique is used to derive the bootstrap confidence intervals. Under the Bayesian paradigm, the point estimates of the unknown parameters for different symmetric, asymmetric, and balanced loss functions and highest posterior density (HPD) credible intervals (CIs) are derived via Gibbs within metropolis‐hasting sampling procedure. A simulation study is conducted to compare the performance of Bayesian estimates with MLEs. Moreover, we also compare the precision of considered CIs. Finally, a real application is considered for illustration purpose.
Convalescent plasma therapy in an immunocompromised patient with multiple COVID‐19 flares: a case report
Authors: Karaolidou Frini , Loutsidi Natasa‐Eleni , Mellios Zois , Jahaj Edison , Eleftheriou Konstantinos , Pagoni Maria , Mpaltadakis Ioannis , Dimopoulos Athanasios‐Meletios , Kalomenidis Ioannis , Pappas Apostolos G. 
Published: November 2021

AbstractConvalescent plasma (CP) transfusion has been utilized as a salvage therapy in immunocompromised patients with severe COVID‐19 pneumonia. We describe the case of a 45‐year‐old immunocompromised patient, who received CP, in order to control multiple COVID‐19 flares and prolonged SARS‐CoV‐2 viraemia lasting for 2 months after the initial diagnosis.
Lectotypification of Uraria prunellifolia and U. paniculata (Leguminosae): Names associated with medicinally important rare plants
Authors: Gogoi Jahnabi , Rana Tikam Singh 
Published: November 2021

AbstractUraria prunellifolia and U. paniculata are medicinally important, and rare in occurrence. The former is believed to be extinct in some parts of India, and the latter was recently rediscovered. The nomenclatural history of U. prunellifolia and U. paniculata is discussed here, and both the names are typified.
The biomechanistic aspects of renal cortical injury induced by diesel exhaust particles in rats and the renoprotective contribution of quercetin pretreatment: Histological and biochemical study
Authors: Morsi Ahmed A. , Fouad Hanan , Alasmari Wardah Abdullah , Faruk Eman Mohamed 
Published: November 2021

AbstractAlthough several studies have reported a toxic effect of diesel exhaust particles (DEP) exposure on the kidney tissues, the involvement of autophagy/NF‐kB signaling as encountered mechanisms and the protective effects of a natural flavonoid, quercetin on DEP remains unclear. Thirty‐two albino rats were divided as control, quercetin‐treated (60 mg/kg, oral), DEP‐exposed (0.5 mg/kg, intra‐tracheal), and quercetin/DEP‐exposed groups. Specimens of the renal cortex were subjected to histo‐biochemical study and immunohistochemical analysis using anti‐NF‐kB, and anti‐LC3β antibodies followed by morphometric and statistical analyses. The expression level of autophagy genes was quantitatively evaluated using RT‐PCR, as well. The DEP‐exposed rats showed an elevation in the renal tissue levels of MDA and a decrease in the catalase and superoxide dismutase (p < .05). Histologically, there were cytoplasmic vacuolar changes in the lining cells of the renal tubules, glomerular atrophy, and vascular congestion. In addition, renal inflammation was evident as confirmed by the increased NF‐kB immunoexpression. Moreover, the gene expression of Becn1, ATG5, and LC3β increased (p <. 0) due to DEP exposure. Conversely, quercetin pretreatment improved these renal histo‐biochemical alterations (p < .05) and regulated autophagy/NF‐kB pathways. Overall, the study proved the renal toxicity mediated by DEP exposure via precipitating renal inflammation, autophagy activation, and oxidative stress. Quercetin pretreatment could antagonize such machinery to protect the kidney against DEP.
Survey investigating the reasons why UK‐based gundogs ceased working between 2010 and 2019
Authors: Houlton John Edwin Freeman 
Published: November 2021

AbstractBackgroundTo determine the longevity of the working life of gundogs in the UK, whether owners’ considered retirement was premature and to identify risk factors associated with such work.MethodsA web‐based survey seeking owner information as to the longevity of their dogs’ working life and why they were retired, euthanised or died. The sample population is six hundred sixty‐five dogs.ResultsThe median age at which Springer spaniels stopped work was 11 years and for Cocker spaniels, it was 9 years. The median age for Labrador retrievers was 10 years; for Golden retrievers, 11 years and Flat‐coated retrievers, 9.5 years. Cocker spaniels stopped work at a significantly younger age than Springer spaniels (p = 0.0003) or Labrador retrievers (p = 0.0407). There was no significant difference between the other major breeds. The majority of owners (54.3%) were satisfied with the working lifespan of their dog.Seventy per cent of dogs were retired, the three most prevalent reasons being lameness (25.2%), old age (23.7%) and deafness (7.8%). Forty‐four dogs died (6.6%) and 158 (24%) were euthanised, with cancer (58%) being the most common reason.ConclusionsNo work‐related issues were identified and gundogs appear to have similar causes of mortality to the general canine population.
Prediction of record values by using quantile regression curves and distortion functions
Authors: Navarro Jorge 
Published: November 2021

AbstractThe purpose of the paper is to provide a general method based on conditional quantile curves to predict record values from preceding records. The predictions are based on conditional median (or median regression) curves. Moreover, conditional quantiles curves are used to provide confidence bands for these predictions. The method is based on the recently introduced concept of multivariate distorted distributions that are used instead of copulas to represent the dependence structure. This concept allows us to compute the conditional quantile curves in a simple way. The theoretical findings are illustrated with a non-parametric model (standard uniform), two parametric models (exponential and Pareto), and a non-parametric procedure for the general case. A real data set and a simulated case study in reliability are analysed.
Challenging problems of quality assurance and quality control (QA/QC) of meteorological time series data
Authors: Faybishenko B. , Versteeg R. , Pastorello G. , Dwivedi D. , Varadharajan C. , Agarwal D. 
Published: November 2021

AbstractRepresentativeness and quality of collected meteorological data impact accuracy and precision of climate, hydrological, and biogeochemical analyses and predictions. We developed a comprehensive Quality Assurance (QA) and Quality Control (QC) statistical framework, consisting of three major phases: Phase I—Preliminary data exploration, i.e., processing of raw datasets, with the challenging problems of time formatting and combining datasets of different lengths and different time intervals; Phase II—QA of the datasets, including detecting and flagging of duplicates, outliers, and extreme data; and Phase III—the development of time series of a desired frequency, imputation of missing values, visualization and a final statistical summary. The paper includes two use cases based on the time series data collected at the Billy Barr meteorological station (East River Watershed, Colorado), and the Barro Colorado Island (BCI, Panama) meteorological station. The developed statistical framework is suitable for both real-time and post-data-collection QA/QC analysis of meteorological datasets.
The relationship between the laboratory diagnosis of Lyme neuroborreliosis and climate factors in Kalmar County Sweden — an overview between 2008 and 2019
Authors: Keith Kimberly , Årestedt Kristofer , Tjernberg Ivar 
Published: November 2021

Abstract
The purpose of this study was to describe the epidemiology of Lyme neuroborreliosis (LNB) in Kalmar County, in southern Sweden, between 2008 and 2019, and to analyse the relationship between the LNB incidence and climate factors. Data containing cerebrospinal fluid (CSF) cell counts and borrelia CSF/serum antibody index results was received from the departments of clinical chemistry and microbiology at Kalmar County hospital. For this study, we defined LNB as a case with a positive borrelia antibody CSF/serum index and CSF leukocytes > 5 × 106/L. Climate data including mean temperature, humidity and precipitation covering Kalmar County was collected from the Swedish Meteorological and Hydrological Institute. A total of 5051 paired serum-CSF samples from 4835 patients were investigated of which 251 laboratory LNB cases were found. The average annual LNB incidence in Kalmar County 2008–2019 was 8.8 cases per 100,000 inhabitants. Positive relationships were observed between mean temperature and LNB incidence (p < 0.001) as well as precipitation and LNB incidence (p = 0.003), both with a one calendar month delay. The results suggest an association between climate factors such as mean temperature and precipitation and LNB incidence, presumably through increased/decreased human-tick interactions. This calls for increased awareness of LNB in both the short perspective after periods of warmth and heavy precipitation as well as in a longer perspective in relation to possible climate change. Further studies with larger study groups, covering other geographical areas and over longer periods of time are needed to confirm these findings.
When color coding backfires: A guidance reversal effect when learning with realistic visualizations
Authors: Skulmowski Alexander 
Published: November 2021

AbstractDigital learning increasingly makes use of realistic visualizations, although realism can be demanding for learners. Color coding is a popular way of helping learners understand visualizations and has been found to aid in learning with detailed visualizations. However, previous research has shown that color coding must not always be an effective aid, and that it even may reduce retention when used with simple visualizations. This study assessed whether the presence of color coding in learning tests has an effect after having learned using a detailed visualization that either featured color cues or one that did not. The results indicate that color coding helps learners the most if the learning tests also feature color coding. Importantly, learning with color-coded visualizations and being tested without color cues leads to the worst results in retention and transfer tests. Regarding transfer, color coding in the testing visualization boosts performance regardless of the presence of color cues in the learning phase. The results of this study challenge popular perspectives aiming at optimizing learning by removing potential sources of difficulty. Depending on the learning test, it may be more effective to keep a certain level of difficulty in the learning task when learning with digital media.
Norms2: Norms About Norms
Authors: Lisciandra Chiara 
Published: November 2021

AbstractIn this paper, I outline and defend the view that variations in compliance levels with one and the same norm represent differentnorms about following norms. In support of this claim, I first argue that classic game-theoretic accounts, which define norms as Nash equilibria of noncooperative games, typically consider variations in compliance levels as separate norms. After that, I suggest a more fine-grained, game-theoretic distinction that accounts for degrees of compliance with the same norm and I show how to incorporate such an account into a psychological framework. Finally, the paper examines what given degrees of compliance can reveal about the dynamics underlying the process of norm change. I will argue that they are indicators of different reactions to the introduction of new norms.
The THESEUS space mission: science goals, requirements and mission concept
Authors: Amati L. , O’Brien P.T. , Götz D. , Bozzo E. , Santangelo A. , Tanvir N. , Frontera F. , Mereghetti S. , Osborne J. P. , Blain A. , Basa S. , Branchesi M. , Burderi L. , Caballero-García M. , Castro-Tirado A. J. , Christensen L. , Ciolfi R. , De Rosa A. , Doroshenko V. , Ferrara A. , Ghirlanda G. , Hanlon L. , Heddermann P. , Hutchinson I. , Labanti C. , Le Floch E. , Lerman H. , Paltani S. , Reglero V. , Rezzolla L. , Rosati P. , Salvaterra R. , Stratta G. , Tenzer C. ,   on behalf of THESEUS Consortium
Published: November 2021

AbstractTHESEUS, one of the two space mission concepts being studied by ESA as candidates for next M5 mission within its Comsic Vision programme, aims at fully exploiting Gamma-Ray Bursts (GRB) to solve key questions about the early Universe, as well as becoming a cornerstone of multi-messenger and time-domain astrophysics. By investigating the first billion years of the Universe through high-redshift GRBs, THESEUS will shed light on the main open issues in modern cosmology, such as the population of primordial low mass and luminosity galaxies, sources and evolution of cosmic re-ionization, SFR and metallicity evolution up to the “cosmic dawn” and across Pop-III stars. At the same time, the mission will provide a substantial advancement of multi-messenger and time-domain astrophysics by enabling the identification, accurate localisation and study of electromagnetic counterparts to sources of gravitational waves and neutrinos, which will be routinely detected in the late ‘20s and early ‘30s by the second and third generation Gravitational Wave (GW) interferometers and future neutrino detectors, as well as of all kinds of GRBs and most classes of other X/gamma-ray transient sources. Under all these respects, THESEUS will provide great synergies with future large observing facilities in the multi-messenger domain. A Guest Observer programme, comprising Target of Opportunity (ToO) observations, will expand the science return of the mission, to include, e.g., solar system minor bodies, exoplanets, and AGN.