bluuebunny/crossref_metadata_2025_split huggingface dataset:
Making meaning of the new identity‐as‐resident: A grounded theory study
Authors: Gautam Sital , Montayre Jed , Neville Stephen 
Published: November 2021

AbstractResidential living has the potential to threaten older adults' established identity. This study utilized grounded theory methodology to explore how older adults make meaning of the new identity‐as‐resident in a residential aged care facility. Using theoretical sampling, in‐depth semi‐structured interviews and observation within interviews were conducted with 17 residents from two Nepalese residential aged care facilities. Data analysis involved the process of open, axial, selective coding, and constant comparative analysis as specified by grounded theory methodology. The process that older adults experience in making meaning of their new identity‐as‐resident involved phases of isolating, exploring, evaluating, and compromising, which led in consequence to internalization of the new identity. Furthermore, it was found that this process depends on the facility structure, rules and regulations, and the attitudes and practices of nurses/caregivers. A focus on these facilitators is crucial for managers and nurses/caregivers working in residential aged care to assist residents in constructing a positive identity‐as‐resident. The findings can potentially be beneficial for raising awareness, educating nurses/caregivers, developing policies for promoting a positive identity‐as‐resident in residential aged care facilities worldwide.
Engaging consumers and health professionals in collaborative decision‐making to optimize care
Authors: Wu Chiung‐Jung ( Jo) , Giles Megan , Terblanche Morne , Drabble Anne 
Published: November 2021

AbstractShared communication and collaborative decision‐making between consumers and health professionals is essential in optimizing the quality of consumer care. However, the consumers' ability to ask questions and seek answers, as well as health professionals' communication skills to engage with the consumer, are necessary considerations for the collaborative decision‐making process. This quality improvement initiative sought to understand the context of collaborative decision making from the perspective of consumers and health professionals adapted from the international Choosing Wisely program. Findings indicated health professionals acknowledged a problem with unnecessary and overuse of tests, treatments, and procedures. Consumers suggested they were confident asking questions about their health and care. The findings of this study highlight collaborative decision‐making as a worthwhile and beneficial undertaking.
Group‐based instant messaging in Finnish residential elder care work: Taming the technology or vice versa?
Authors: Hirvonen Helena , Tammelin Mia , Hämäläinen Antti , Taipale Sakari 
Published: November 2021

AbstractAs new communication technologies become embedded in care work, there is a need to understand how they affect its temporal order. This article analyses group‐based mobile instant messaging (IM) in residential elder care work in Finland. The article asks (i) how care workers use group‐based messaging for work; and (ii) how they negotiate the rules for its use. Theoretically, the article draws on science and technology studies focusing on ‘taming’ and ‘unleashing’ (Pols, 2017), and temporality (Wajcman, 2008). Analysis is based on a qualitative interview study of care workers and nurses (n = 25) conducted in 2018. The results showed how the time‐shifting functionality of IM allows employees to ‘tame the technology’ and unleash effective communication practices. However, IM also increases a risk of boundless accessibility and tames its users, pointing to a growing need for time work to manage their work‐life balance in the complex temporal order of care work.
Phenotype transition of fibroblasts incorporated into patient‐derived oral carcinoma organoids
Authors: Chen Xu , Li Rui , Zhao Hui , Wang Xinmiao , Shao Zhe , Shang Zhengjun 
Published: November 2021

AbstractObjectiveCancer‐associated fibroblasts (CAFs) are abundantly infiltrated in oral squamous cell carcinoma (OSCC), but the contact‐dependent mechanisms that regulate CAFs phenotype in precursor cells, such as paracancerous fibroblasts (PFs), remain unclear. Here, a fibroblast‐attached organoid (FAO) model was initiated to determine phenotype transition of fibroblasts triggered by contact with OSCC.Material and methodsOrganoids and fibroblasts were generated using OSCC and adjacent tissues. Cell‐clusters containing fibroblasts and tumour cells were aggregated to allow for FAOs expansion. Immunoblotting assay was performed to compare expression of Notch intracellular domain (NICD) in CAFs and PFs. Colony formation assay was employed to evaluate morphological activation of fibroblasts.ResultsCompared to traditional 3D co‐culture, FAOs better modulated the spatial distribution of fibroblasts with tumour nests. The presence of CAFs with multiple branches was stably observed in FAOs during serial passage. Incorporation with organoids promoted the ability of PFs to form multiple branches. Immunoblotting assay confirmed higher NICD level in CAFs than PFs. Treatment with Notch inhibitor, N‐[N‐(3, 5‐difluorophenacetyl)‐l‐alanyl]‐S‐phenylglycine t‐butyl ester (i.e. DAPT) blocked morphological activation of fibroblasts incorporated into FAO.ConclusionWe developed a robust strategy to study contact‐dependent mechanisms underlying tumour‐stromal interaction, and suggested that Notch activity contributes to biogenesis of OSCC‐associated fibroblasts.
Going around in circles. Is there a continuing need to use the T‐piece circuit in the practice of pediatric anesthesia?
Authors: Arnold Philip , Kaufmann Jost 
Published: November 2021

AbstractAnesthetic equipment, including breathing circuits, has evolved over time. The T‐piece circuit, in its various forms, was designed to meet the needs of its time. As equipment and techniques have moved on, it is timely to consider the place of the T‐piece in modern pediatric anesthetic practice. Today the circle system is a ubiquitous part of anesthesia. When integrated with a modern anesthetic machine it offers precise control of ventilation together with continuous monitoring of airway pressure and flow: but at the cost of complexity. In comparison the T‐piece offers a simple cheap lightweight design, so ergonomic in use that it almost becomes part of the anesthetist: but lacks the control and the barriers to unsafe use of more sophisticated systems. In addition, it requires high fresh gas flow adding to cost and environmental pollution. This pro‐con debate discusses whether there remains a case for continuing to use the T‐piece circuit in preference over other options. Possible indications for the T‐Piece are discussed together with alternative strategies. The limitations of the circle system, the T‐piece, and other alternative (such as self‐inflating resuscitator bag) are discussed with respect to pediatric anesthetic practice.
Extracorporeal membrane oxygenation as rescue therapy in a pediatric liver transplant recipient with very severe hepatopulmonary syndrome
Authors: Huang Joy , Yoeli Dor , Sundaram Shikha S , Carpenter Todd , Annam Aparna , Pahlavan Sheila , Wachs Michael , Adams Megan A. 
Published: November 2021

AbstractBackgroundIn children with cirrhosis, the prevalence of HPS ranges from 3% to 20%, resulting in impaired gas exchange due to alterations in pulmonary microvasculature. LT is the gold‐standard cure for cirrhosis complicated by HPS and should ideally be performed prior to the development of severe HPS due to increased risk for post‐transplant hypoxia, right heart failure, and outflow obstruction.MethodsWe present a case of a 13‐year‐old man, who underwent pediatric LT for severe HPS complicated by postoperative respiratory collapse, requiring a 92‐day course of veno‐venous ECMO.ResultsPost‐transplant, despite BiPAP, inhaled nitric oxide and isoproterenol infusion, he remained hypoxic postoperatively and acutely decompensated on postoperative day 25, requiring veno‐venous ECMO. After 84 days on ECMO, a persistent large splenorenal shunt was identified that was embolized by interventional radiology, and 8 days after shunt embolization and ASD closure, he was successfully weaned off ECMO.ConclusionsThis case describes the longest known duration of ECMO in a pediatric LT recipient and a unique improvement in hypoxemia following a portosystemic shunt closure. ECMO presents a heroic rescue measure for pediatric LT recipients with HPS that develops acute respiratory failure postoperatively refractory to alternative measures.
Flower morphology and plant–bee pollinator interactions are related to stamen dimorphism in Melastomataceae
Authors: Valadão‐Mendes L. B. , Rocha I. , Meireles D. A. L. , Leite F. B. , Sazima M. , Maruyama P. K. , Brito V. L. G. 
Published: November 2021

Abstract

Approximately 20,000 species of flowering plant offer mainly pollen to their pollinators, generally bees. Stamen dimorphism, a floral trait commonly present in some pollen flowers, is thought to be associated with exclusive pollen provision for highly effective bee pollinators. Notwithstanding, little is known about how stamen dimorphism is related to other floral morphological traits and, consequently, plant–pollinator interactions at the community scale. Here we investigated the relationship between stamen dimorphism and other floral morphological traits, as well as the interactions with pollinators in plants of Melastomataceae.

We characterized each plant species as stamen dimorphic or stamen isomorphic according to differences in size and shape between stamen sets. Data on interactions between the plants and their bee pollinators were analysed as quantitative bipartite networks.

We found that petal and style size and shape were correlated to stamen dimorphism. Stamen dimorphic species present larger flowers and less variable style shapes than stamen isomorphic species. Furthermore, stamen dimorphism is associated with higher richness of visiting bees, i.e. higher ecological generalization.

During the evolutionary history of Melastomataceae, the dependence on pollinators for fruit set has possibly favoured the evolution of larger flowers with dimorphic stamens, which in turn are able to make use of a larger spectrum of pollen‐collecting bees, leading to ecological generalization.
Follicle‐stimulating hormone regulates glycolysis of water buffalo follicular granulosa cells through AMPK/SIRT1 signalling pathway
Authors: Pan Yu , Zhu Jianzong , Lv Qiao , Shi Deshun , Yang Sufang , Xing Qinghua , Zhang Ruimen , Cheng Juanru , Deng Yanfei 
Published: November 2021

AbstractGlycolysis in follicular granulosa cells (GCs) is the primary source of energy metabolism substrate of oocytes and is closely related to follicular development in mammals. Many physiological functions of GCs are regulated by follicle‐stimulating hormone (FSH). In contrast, whether FSH regulates the glycolysis of GCs and its mechanism remains unclear. This study explored the correlation between FSH concentration and glycolysis level of GCs from different diameters of water buffalo follicles, and further explored the mechanism of FSH regulation in glycolysis in vitro cultured GCs. Results showed the variation trend of lactic acid concentration in follicular fluid and the expression level of glycolysis‐related genes in GCs were consistent with the variation trend of FSH concentration in follicular fluid from follicles with different diameters. When GCs were treated with FSH in vitro, the expression level of glycolysis‐related genes, lactate production and glucose uptake increased correspondingly (p < .05). Furthermore, we found that expression trend of AMPK/Sirtuin1 (SIRT1) pathway‐related genes in GCs was consistent with the expression trend of glycolysis‐related genes and was positively correlated with FSH concentrations in vivo or cultured in vitro. Activation of SIRT1 increased the expression level of glycolytic key proteins and lactic acid production in GCs, while inhibition of SIRT1 showed the opposite effect. In general, glycolysis in water buffalo GCs in vivo or cultured in vitro was positively correlated with FSH concentration. AMPK/SIRT1 pathway plays an important role in the regulation of FSH on glycolysis in GCs. Our findings will enrich the understanding of FSH regulating the development of water buffalo follicles.
Distress tolerance as a moderator of the dynamic associations between interpersonal needs and suicidal thoughts
Authors: Kyron Michael J. , Hooke Geoff R. , Bryan Craig J. , Page Andrew C. 
Published: November 2021

AbstractBackgroundIdentifying the interaction between dispositional and dynamic risk factors is necessary in understanding, predicting, and managing suicide risk. Interpersonal factors have consistently been linked to suicidal ideation over short‐term periods. Additionally, distress tolerance may be a relevant dispositional protective factor against stressful events.MethodsSeven hundred and seventeen psychiatric inpatients (Male = 30.31%, Average Age = 40.71 years, Min = 14, Max = 82) self‐reported their distress tolerance at hospital admission, and interpersonal needs and suicidal ideation on a daily basis. Dynamic structural equation modelling was used to examine whether within‐level dynamics were moderated by distress tolerance.ResultsBoth perceived burdensomeness and thwarted belongingness were significantly associated with same‐day suicidal ideation. Higher distress tolerance was associated with weaker daily associations between suicidal ideation and both perceived burdensomeness and thwarted belongingness. Distress tolerance was also associated with lower variability in suicidal ideation. Moderating effects were also evident when lifetime suicide attempts were added as a covariate, which was associated with stronger associations between interpersonal dysfunction and suicidal ideation, and higher variability in ideation.ConclusionsDistress tolerance may be important to consider when examining the dynamic relationships between suicidal ideation and proximal factors. Psychotherapy that specifically targets distress tolerance may be effective in reducing reactivity to interpersonal stressors.
The Added Value of Configurational Meta‐analyses
Authors: Veri Francesco , Barrowman Hannah 
Published: November 2021

AbstractThis article discusses the challenges facing meta‐analyses considering multiple sources of heterogeneity in peer‐reviewed studies. While quantitative meta‐analysis can control or correct sources of heterogeneity, it focuses on the search for statistical consistency which limits the extent of causal inference and generalisation. In contrast, qualitative approaches for meta‐analysis tend to integrate various sources of heterogeneity through interpretive approaches. However, this integrative strategy leads to a constitutive or functional relationship between analysed constructs with limited capacity for theory testing. Comparative configurational meta‐analysis (CFG‐MA), a diversity‐oriented approach, has an overall advantage in managing heterogeneity as it recognises the uniqueness of the cases and their within‐case diversity by keeping the assumption of cross‐case causal complexity. CFG‐MA allows the integration of various sources of heterogeneity and the production of cross‐cases and within‐cases inference and generalisation.
Enhancing the sweat resistance of sunscreens
Authors: Keshavarzi Fatemeh , Knudsen Nina Østergaard , Komjani Niloufarsadat Mirmahdi , Ebbesen Morten F. , Brewer Jonathan R. , Jafarzadeh Shadi , Thormann Esben 
Published: November 2021

AbstractBackgroundWhile sunbathing of performing outdoor sport activities, sunscreens are important for protection of uncovered skin against ultraviolet (UV) radiation. However, perspiration negatively affects the performance of a sunscreen film by weakening its substantivity and uniformity through the activation of two mechanisms, namely sunscreen wash‐off and sunscreen redistribution.Material and methodsWe used a perspiring skin simulator to investigate the effect of sunscreen formulation on its efficiency upon sweating. Specifically, we modified the sunscreen formulation by incorporating a hydrophobic film former and adding water‐absorbing particles. Sunscreen performance before and after perspiration is assessed by in vitro sun protection factor measurements, direct detection of changes in the sunscreen distribution using UV reflectance imaging, and by coherent anti‐Stokes Raman scattering (CARS) microscopy for microscopic characterization of the UV filter relocation.ResultsThe results show that incorporating a hydrophobic film former can decrease sunscreen wash‐off due to sweating, while an excessive amount of film former might negatively affect the sunscreen distribution. The addition of water‐absorbing particles, on the other hand, had either a negative or positive impact on the sunscreen substantivity, depending on the particle properties. While the addition of large water‐absorbing particles appeared to increase sunscreen redistribution, smaller particles that could form a gel‐like structure upon contact with water, appeared to change sunscreen wetting and sweat droplet spreading, thereby decreasing sunscreen wash‐off and sunscreen redistribution.ConclusionsWe find that using a combination of hydrophobic film formers, which increase water resistance, and small water‐absorbing particles, which change the wetting behavior, can make sunscreen formulations more sweat‐resistant and less runny.
The Arabidopsis electron‐transfer flavoprotein:ubiquinone oxidoreductase is required during normal seed development and germination
Authors: da Fonseca‐Pereira Paula , Pham Phuong Anh , Cavalcanti João Henrique F. , Omena‐Garcia Rebeca P. , Barros Jessica A. S. , Rosado‐Souza Laise , Vallarino José G. , Mutwil Marek , Avin‐Wittenberg Tamar , Nunes‐Nesi Adriano , Fernie Alisdair R. , Araújo Wagner L. 
Published: November 2021

SUMMARYThe importance of the alternative donation of electrons to the ubiquinol pool via the electron‐transfer flavoprotein/electron‐transfer flavoprotein:ubiquinone oxidoreductase (ETF/ETFQO) complex has been demonstrated. However, the functional significance of this pathway during seed development and germination remains to be elucidated. To assess the function of this pathway, we performed a detailed metabolic and transcriptomic analysis of Arabidopsis mutants to test the molecular consequences of a dysfunctional ETF/ETFQO pathway. We demonstrate that the disruption of this pathway compromises seed germination in the absence of an external carbon source and also impacts seed size and yield. Total protein and storage protein content is reduced in dry seeds, whilst sucrose levels remain invariant. Seeds of ETFQO and related mutants were also characterized by an altered fatty acid composition. During seed development, lower levels of fatty acids and proteins accumulated in the etfqo‐1 mutant as well as in mutants in the alternative electron donors isovaleryl‐CoA dehydrogenase (ivdh‐1) and d‐2‐hydroxyglutarate dehydrogenase (d2hgdh1‐2). Furthermore, the content of several amino acids was increased in etfqo‐1 mutants during seed development, indicating that these mutants are not using such amino acids as alternative energy source for respiration. Transcriptome analysis revealed alterations in the expression levels of several genes involved in energy and hormonal metabolism. Our findings demonstrated that the alternative pathway of respiration mediated by the ETF/ETFQO complex affects seed germination and development by directly adjusting carbon storage during seed filling. These results indicate a role for the pathway in the normal plant life cycle to complement its previously defined roles in the response to abiotic stress.
Cell cycle checkpoint control in response to DNA damage by environmental stresses
Authors: Pedroza‐Garcia José Antonio , Xiang Yanli , De Veylder Lieven 
Published: November 2021

SUMMARYBeing sessile organisms, plants are ubiquitously exposed to stresses that can affect the DNA replication process or cause DNA damage. To cope with these problems, plants utilize DNA damage response (DDR) pathways, consisting of both highly conserved and plant‐specific elements. As a part of this DDR, cell cycle checkpoint control mechanisms either pause the cell cycle, to allow DNA repair, or lead cells into differentiation or programmed cell death, to prevent the transmission of DNA errors in the organism through mitosis or to its offspring via meiosis. The two major DDR cell cycle checkpoints control either the replication process or the G2/M transition. The latter is largely overseen by the plant‐specific SOG1 transcription factor, which drives the activity of cyclin‐dependent kinase inhibitors and MYB3R proteins, which are rate limiting for the G2/M transition. By contrast, the replication checkpoint is controlled by different players, including the conserved kinase WEE1 and likely the transcriptional repressor RBR1. These checkpoint mechanisms are called upon during developmental processes, in retrograde signaling pathways, and in response to biotic and abiotic stresses, including metal toxicity, cold, salinity, and phosphate deficiency. Additionally, the recent expansion of research from Arabidopsis to other model plants has revealed species‐specific aspects of the DDR. Overall, it is becoming evidently clear that the DNA damage checkpoint mechanisms represent an important aspect of the adaptation of plants to a changing environment, hence gaining more knowledge about this topic might be helpful to increase the resilience of plants to climate change.
Economic evaluations of interventions for the prevention and treatment of pressure ulcers: an umbrella review protocol
Authors: Klugarová Jitka , Pokorná Andrea , Hussain Salman , Vrbová Tereza , Slezáková Simona , Búřilová Petra , Saibertová Simona , Dolanová Dana , Klugar Miloslav 
Published: November 2021

ABSTRACT

Objective:
The objective of this review is to synthesize the findings of economic evaluations of preventing or treating pressure ulcers.

Introduction:
Pressure ulcers are one of the most common preventable complications characterized by local tissue injury. Pressure ulcers increase mortality rates, impair quality of life, increase the length of hospital stay, and alter overall health outcomes. Published studies have found higher costs associated with treating pressure ulcers than preventing them, with treatment cost varying based on the pressure ulcer category (the greater the category, the higher the cost). We will systematically review the evidence on preventing or treating pressure ulcers from an economic perspective.

Inclusion criteria:
We will include systematic reviews that investigate both the cost and outcomes associated with the prevention or treatment of pressure ulcers. Systematic reviews dealing with economic evaluation of wound care or management will be excluded if they have not provided separate information for pressure ulcers.

Methods:
Epistemonikos, MEDLINE, NHS Economic Evaluation Database, and the Canadian Agency for Drugs and Technologies in Health (CADTH) website will be searched for relevant systematic reviews from inception and without any language restrictions. Titles and abstracts will be screened at the initial stage, followed by full-text screening. Quality assessment will be done using the standard JBI critical appraisal instrument for systematic reviews and research syntheses. Article screening, data extraction, and quality assessment will be performed by two reviewers independently. All economic health outcomes will be considered under the primary outcomes of the study.

Systematic review registration number:
Open Science Framework (https://osf.io/9y2a7/).