bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of upper endoscopies with random biopsies to identify patients with gastric premalignant lesions who can safely be exempt from surveillance
Authors: Mommersteeg Michiel C. , Nieuwenburg Stella A. V. , den Hollander Wouter J. , Holster Lisanne , den Hoed Caroline M. , Capelle Lisette G. , Tang Tjon J. , Anten Marie- Paule , Prytz-Berset Ingrid , Witteman Ellen M. , ter Borg Frank , Burger Jordy P. W. , Doukas Michail , Bruno Marco J. , Peppelenbosch Maikel P. , Fuhler Gwenny M. , Kuipers Ernst J. , Spaander Manon C. W. 
Published: February 2021

Abstract
Introduction
Guidelines recommend endoscopy with biopsies to stratify patients with gastric premalignant lesions (GPL) to high and low progression risk. High-risk patients are recommended to undergo surveillance. We aimed to assess the accuracy of guideline recommendations to identify low-risk patients, who can safely be discharged from surveillance.

Methods
This study includes patients with GPL. Patients underwent at least two endoscopies with an interval of 1–6 years. Patients were defined ‘low risk’ if they fulfilled requirements for discharge, and ‘high risk’ if they fulfilled requirements for surveillance, according to European guidelines (MAPS-2012, updated MAPS-2019, BSG). Patients defined ‘low risk’ with progression of disease during follow-up (FU) were considered ‘misclassified’ as low risk.

Results
334 patients (median age 60 years IQR11; 48.7% male) were included and followed for a median of 48 months. At baseline, 181/334 (54%) patients were defined low risk. Of these, 32.6% were ‘misclassified’, showing progression of disease during FU. If MAPS-2019 were followed, 169/334 (51%) patients were defined low risk, of which 32.5% were ‘misclassified’. If BSG were followed, 174/334 (51%) patients were defined low risk, of which 32.2% were ‘misclassified’. Seven patients developed gastric cancer (GC) or dysplasia, four patients were ‘misclassified’ based on MAPS-2012 and three on MAPS-2019 and BSG. By performing one additional endoscopy 72.9% (95% CI 62.4–83.3) of high-risk patients and all patients who developed GC or dysplasia were identified.

Conclusion
One-third of patients that would have been discharged from GC surveillance, appeared to be ‘misclassified’ as low risk. One additional endoscopy will reduce this risk by 70%.
Discounting in economic evaluation of healthcare interventions: what about the risk term?
Authors: Hultkrantz Lars 
Published: February 2021

AbstractResults from economic evaluations of long-term outcomes are strongly dependent on the chosen discount rate. A recent review of national guidelines for evaluation of healthcare interventions finds that “the level of currently used discount rates seems relatively high in many countries”. However, this conclusion comes from a comparison to rates derived or observed for investments in safe assets, while rate of return requirements are typically considerably higher when investment involves risk. This paper reviews recent literature on how to account for project-specific risk in determination of the social rate of discount and discusses implications for economic evaluation of healthcare interventions. It concludes that the available empirical evidence strongly suggests that the demand for and consumer value of health and healthcare is co-variant with income, which therefore implies that there is a non-diversifiable risk component of health-related investment.
The biotechnological importance of the plant-specific NAC transcription factor family in crop improvement
Authors: Singh Sadhana , Koyama Hiroyuki , Bhati Kaushal K. , Alok Anshu 
Published: February 2021

AbstractClimate change, malnutrition, and food insecurity are the inevitable challenges being faced by the agriculture sector today. Plants are susceptible to extreme temperatures during the crucial phases of flowering and seed development, and elevated carbon levels also lead to yield losses. Productivity is also affected by floods and droughts. Therefore, increasing plant yield and stress tolerance are the priorities to be met through novel biotechnological interventions. The contributions of NAC genes towards enhancing plant survivability under stress is well known. Here we focus on the potential of NAC genes in the regulation of abiotic stress tolerance, secondary cell wall synthesis, lateral root development, yield potential, seed size and biomass, ROS signaling, leaf senescence, and programmed cell death. Once naturally tolerant candidate NAC genes have been identified, and the nature of their association with growth and fitness against multi-environmental stresses has been determined, they can be exploited for building inherent tolerance in future crops via transgenic technologies. An update on the latest developments is provided in this review, which summarizes the current understanding of the roles of NAC in the establishment of various stress-adaptive mechanisms in model and food crop plants.
Cost of groundwater protection: major groundwater basin protection zones in Poland
Authors: Krogulec Ewa , Gurwin Jacek , Wąsik Mirosław 
Published: February 2021

AbstractThis paper describes the complex hydrogeological, legal framework and socioeconomic costs of the groundwater protection in major groundwater basins (MGBs) in Poland in accordance with European directives. The hydrogeological criteria developed in Poland for establishing MGBs and the principles of their protection provide more details to the directives that are in force in Europe, which define the general principles for groundwater protection. The procedure of establishing MGB protection zones is connected with a change in local plans and land development and requires an analysis of the cost–benefit relationship in the sphere of social economy in the sector of public economics. The cost assessment was performed on the basis of data from hydrogeological documentations, and the aggregation of subareas to which the same existing and planned development can be attributed. A legal analysis of bans, orders and restrictions together with the identification of the risk of claims in specific hydrogeological and development conditions was a fundamental issue of research. These costs depend on the acreage and land use of the protected area. The unit costs of MGB protection, calculated per 1 km2 of the protection area, for six sample basins were estimated at €120 to €208,000/2 years/1 km2. The highest costs are generated by establishing protection in urban areas, while the lowest costs are generated in forest areas.
Phase-contrast and dark-field imaging for the inspection of resin-rich areas and fiber orientation in non-crimp vacuum infusion carbon-fiber-reinforced polymers
Authors: Glinz Jonathan , Šleichrt Jan , Kytýř Daniel , Ayalur-Karunakaran Santhosh , Zabler Simon , Kastner Johann , Senck Sascha 
Published: February 2021

AbstractIn this work, we present a multimodal approach to three-dimensionally quantify and visualize fiber orientation and resin-rich areas in carbon-fiber-reinforced polymers manufactured by vacuum infusion. Three complementary image modalities were acquired by Talbot–Lau grating interferometer (TLGI) X-ray microcomputed tomography (XCT). Compared to absorption contrast (AC), TLGI-XCT provides enhanced contrast between polymer matrix and carbon fibers at lower spatial resolutions in the form of differential phase contrast (DPC) and dark-field contrast (DFC). Consequently, relatively thin layers of resin, effectively indiscernible from image noise in AC data, are distinguishable. In addition to the assessment of fiber orientation, the combination of DPC and DFC facilitates the quantification of resin-rich areas, e.g., in gaps between fiber layers or at binder yarn collimation sites. We found that resin-rich areas between fiber layers are predominantly developed in regions characterized by a pronounced curvature. In contrast, in-layer resin-rich areas are mainly caused by the collimation of fibers by binder yarn. Furthermore, void volume around two adjacent 90°-oriented fiber layers is increased by roughly 20% compared to a random distribution over the whole specimen.
Solving mixed-integer nonlinear optimization problems using simultaneous convexification: a case study for gas networks
Authors: Liers Frauke , Martin Alexander , Merkert Maximilian , Mertens Nick , Michaels Dennis 
Published: February 2021

AbstractSolving mixed-integer nonlinear optimization problems (MINLPs) to global optimality is extremely challenging. An important step for enabling their solution consists in the design of convex relaxations of the feasible set. Known solution approaches based on spatial branch-and-bound become more effective the tighter the used relaxations are. Relaxations are commonly established by convex underestimators, where each constraint function is considered separately. Instead, a considerably tighter relaxation can be found via so-called simultaneous convexification, where convex underestimators are derived for more than one constraint function at a time. In this work, we present a global solution approach for solving mixed-integer nonlinear problems that uses simultaneous convexification. We introduce a separation method that relies on determining the convex envelope of linear combinations of the constraint functions and on solving a nonsmooth convex problem. In particular, we apply the method to quadratic absolute value functions and derive their convex envelopes. The practicality of the proposed solution approach is demonstrated on several test instances from gas network optimization, where the method outperforms standard approaches that use separate convex relaxations.
My Data, My Choice? – German Patient Organizations’ Attitudes towards Big Data-Driven Approaches in Personalized Medicine. An Empirical-Ethical Study
Authors: Rauter Carolin Martina , Wöhlke Sabine , Schicktanz Silke 
Published: February 2021

AbstractPersonalized medicine (PM) operates with biological data to optimize therapy or prevention and to achieve cost reduction. Associated data may consist of large variations of informational subtypes e.g. genetic characteristics and their epigenetic modifications, biomarkers or even individual lifestyle factors. Present innovations in the field of information technology have already enabled the procession of increasingly large amounts of such data (‘volume’) from various sources (‘variety’) and varying quality in terms of data accuracy (‘veracity’) to facilitate the generation and analyzation of messy data sets within a short and highly efficient time period (‘velocity’) to provide insights into previously unknown connections and correlations between different items (‘value’). As such developments are characteristics of Big Data approaches, Big Data itself has become an important catchphrase that is closely linked to the emerging foundations and approaches of PM. However, as ethical concerns have been pointed out by experts in the debate already, moral concerns by stakeholders such as patient organizations (POs) need to be reflected in this context as well. We used an empirical-ethical approach including a website-analysis and 27 telephone-interviews for gaining in-depth insight into German POs’ perspectives on PM and Big Data. Our results show that not all POs are stakeholders in the same way. Comparing the perspectives and political engagement of the minority of POs that is currently actively involved in research around PM and Big Data-driven research led to four stakeholder sub-classifications: ‘mediators’ support research projects through facilitating researcher’s access to the patient community while simultaneously selecting projects they preferably support while ‘cooperators’ tend to contribute more directly to research projects by providing and implemeting patient perspectives. ‘Financers’ provide financial resources. ‘Independents’ keep control over their collected samples and associated patient-related information with a strong interest in making autonomous decisions about its scientific use. A more detailed terminology for the involvement of POs as stakeholders facilitates the adressing of their aims and goals. Based on our results, the ‘independents’ subgroup is a promising candidate for future collaborations in scientific research. Additionally, we identified gaps in PO’s knowledge about PM and Big Data. Based on these findings, approaches can be developed to increase data and statistical literacy. This way, the full potential of stakeholder involvement of POs can be made accessible in discourses around PM and Big Data.
Reappraising fear: is up-regulation more efficient than down-regulation?
Authors: Wiemer Julian , Rauner Milena M. , Stegmann Yannik , Pauli Paul 
Published: February 2021

AbstractCatastrophizing thoughts may contribute to the development of anxiety, but functional emotion regulation may help to improve treatment. No study so far directly compared up- and down-regulation of fear by cognitive reappraisal. Here, healthy individuals took part in a cued fear experiment, in which multiple pictures of faces were paired twice with an unpleasant scream or presented as safety stimuli. Participants (N = 47) were asked (within-subjects) to down-regulate, to up-regulate and to maintain their natural emotional response. Valence and arousal ratings indicated successful up- and down-regulation of the emotional experience, while heart rate and pupil dilation increased during up-regulation, but showed no reduction in down-regulation. State and trait anxiety correlated with evaluations of safety but not threat stimuli, which supports the role of deficient safety learning in anxiety. Reappraisal did not modulate this effect. In conclusion, this study reveals evidence for up-regulation effects in fear, which might be even more efficient than down-regulation on a physiological level and highlights the importance of catastrophizing thoughts for the maintenance of fear and anxiety.
The Impact of Differentiation on Cytotoxicity and Insulin Sensitivity in Streptozotocin Treated SH-SY5Y Cells
Authors: Bagaméry Fruzsina , Varga Kamilla , Kecsmár Kitti , Vincze István , Szökő Éva , Tábi Tamás 
Published: February 2021

AbstractRecently neuronal insulin resistance was suggested playing a role in Alzheimer’s disease. Streptozotocin (STZ) is commonly used to induce impairment in insulin metabolism. In our previous work on undifferentiated SH-SY5Y cells the compound exerted cytotoxicity without altering insulin sensitivity. Nevertheless, differentiation of the cells to a more mature neuron-like phenotype may considerably affect the significance of insulin signaling and its sensitivity to STZ. We aimed at studying the influence of STZ treatment on insulin signaling in SH-SY5Y cells differentiated by retinoic acid (RA). Cytotoxicity of STZ or low serum (LS) condition and protective effect of insulin were compared in RA differentiated SH-SY5Y cells. The effect of insulin and an incretin analogue, exendin-4 on insulin signaling was also examined by assessing glycogen synthase kinase-3 (GSK-3) phosphorylation. STZ was found less cytotoxic in the differentiated cells compared to our previous results in undifferentiated SH-SY5Y cells. The cytoprotective concentration of insulin was similar in the STZ and LS groups. However, the right-shifted concentration–response curve of insulin induced GSK-3 phosphorylation in STZ-treated differentiated cells is suggestive of the development of insulin resistance that was further confirmed by the insulin potentiating effect of exendin-4. Differentiation reduced the sensitivity of SH-SY5Y cells for the non-specific cytotoxicity of STZ and enhanced the relative significance of development of insulin resistance. The differentiated cells thus serve as a better model for studying the role of insulin signaling in neuronal survival. However, direct cytotoxicity of STZ also contributes to the cell death.
Effects of oral macimorelin on copeptin and anterior pituitary hormones in healthy volunteers
Authors: Urwyler Sandrine A. , Lustenberger Sven , Drummond Juliana R. , Soares Beatriz Santana , Vogt Deborah R. , Ammer Nicola , Yuen Kevin C. J. , Ribeiro-Oliveira Antonio , Christ-Crain Mirjam 
Published: February 2021

Abstract
Purpose
The test with the highest diagnostic accuracy for diabetes insipidus is copeptin measurement after hypertonic saline infusion. However, the procedure is cumbersome and unpleasant due to rapid sodium increase. An oral stimulation test would be highly desirable. Macimorelin, an oral ghrelin agonist, is a newly approved diagnostic test for growth hormone (GH) deficiency, but its effects on copeptin/vasopressin are unknown and the effects on other pituitary hormones only scarcely investigated.

Methods
In this prospective, interventional, proof-of-concept study Copeptin and anterior pituitary hormones were measured in 28 healthy volunteers on two test days at baseline, 30, 45, 60, 90 and 120 min after a single dose of macimorelin (first visit: 0.5 mg/kg, second visit: 0.75 mg/kg).

Results
Baseline copeptin levels were 5.26 pmol/L [1.57, 6.81] and did not change after macimorelin intake (0.5 mg/kg: maximal median change 0.40 [− 0.49, 0.65] pmol/L, p = 0.442; 0.75 mg/kg: − 0.13 [− 0.45, 0.17] pmol/L, p = 0.442. Median GH levels increased from 3.67 mU/L with a maximal median change of 94.66 [IQR 56.5; 110.96] mU/L, p < 0.001. No effect was seen on cortisol, ACTH, LH and FSH levels. Prolactin (max. median change 100 [2.5; 146.5] mU/L, p = 0.004) and free thyroxine (fT4) (0.5 [0.2; 0.8] pmol/L, p < 0.001) increased, whereas TSH decreased (− 0.18 [− 0.22, − 0.09] mU/L, p < 0.001).

Conclusion
We confirm an increase of GH upon macimorelin in healthy volunteers. However, macimorelin did not stimulate copeptin and therefore does not provide an oral test alternative for the diagnosis of diabetes insipidus. Additionally, a stimulatory effect was seen for prolactin and fT4, but not for ACTH and gonadotropic hormones.

Registration
The trial was registered on ClinicalTrials.gov (NCT03844217) on February 18, 2019.
Indeterminacy, Ideology and Legitimacy in International Investment Arbitration: Controlling International Private Networks of Legal Governance?
Authors: Garcia Blesa Juan J. 
Published: February 2021

AbstractThis article connects the insights of post-realist scholarship about radical indeterminacy and its consequences for the legitimacy of adjudication to the current legitimacy crisis of the international investment regime. In the past few years, numerous studies have exposed serious shortcomings in investment law and arbitration including procedural problems and the substantive asymmetry of the rights protected. These criticisms have prompted a broad consensus in favor of amending the international investment regime and multiple reform proposals have appeared that appeal to the rule of law ideal as an instrument for increasing the acceptability of the international investment system. This article argues that the reliance of such proposals on jurisprudential approaches that fail to adequately accommodate the post-realist indeterminacy critique and take seriously the role of ideology in adjudication renders reform efforts unable to solve the legitimacy problems of the investment regime. The conclusions suggest the need to abandon implausible claims to depoliticization and face the methodological challenges posed by the promise of ideologically balanced assessments advanced by some rule of law theorists. The article finally points at the urgency to reform traditional approaches to doctrinal work in order to increase awareness of critical challenges and open up doctrinal methods to alternative methodological avenues.
A New Film Parameter for Rough Surface EHL Contacts with Anisotropic and Isotropic Structures
Authors: Hansen Jonny , Björling Marcus , Larsson Roland 
Published: February 2021

AbstractNumerous tribological contacts worldwide rely on adequate lubrication quality for proper functionality. Despite this, there is no existing approach to accurately predict the state of lubrication. The default model since introduced in the 1960s—the $$\Lambda$$
Λ
-ratio, defined as the oil film thickness over the surface roughness height—is unpredictable and may yield erroneous results. Here, we put forward a framework for a new updated film parameter, $${\Lambda }^{*}$$

Λ

∗

, which accounts for the elasto-hydrodynamic lubrication (EHL) effects induced by surface irregularities on the microscopic scale (micro-EHL). This new film parameter was validated in ball-on-disc tribological tests with engineering surfaces comprising isotropic and anisotropic structures. As expected, the new model was found to accurately predict the experimentally measured true mixed and full-film EHL regimes. The ability to accurately predict the mode of lubrication represents a major advance in designing tribological interfaces for optimal efficiency and durability.
Does river channelization increase the abundance of invasive crayfish? Survey of Faxonius limosus in small Central European streams
Authors: Bonk Maciej , Bobrek Rafał 
Published: February 2021

AbstractThe aim of this study was to assess whether regulated river reaches show higher numbers of the spiny cheek crayfishFaxonius limosus, a common freshwater invader in Europe. Man-made alterations of riverine habitats may increase their susceptibility to biological invasions. This phenomenon is commonly studied in the context of dam reservoirs; however, the impact of river channelization and the resulting riverine habitat homogenization on the success of invasive species are mostly lacking. Surveys were conducted in natural and channelised river stretches in five rivers of south-central Poland. General linear mixed model analysis showed that crayfish abundance is usually higher at sites located within regulated reaches. The likely reason for the detected differences in abundance of crayfish may be related to decreased food-web complexity and lack of predators in a homogenised habitat. The results suggest that the channelization of small watercourses may increase the abundance of invasive speciesF. limosusand its pressure on native European crayfish. However, due to limited data obtained in field, our study should be considered as a pilot one.
Attitudes Toward Robots as Equipment and Coworkers and the Impact of Robot Autonomy Level
Authors: Latikka Rita , Savela Nina , Koivula Aki , Oksanen Atte 
Published: February 2021

AbstractIncreasingly, people must interact with robot technologies. In this research, we examined attitudes toward robots as equipment and as coworkers and whether these attitudes are affected by the autonomy of the robot among participants living in the United States (Study 1: N = 1003; Study 2: N = 969). Study 1 revealed that respondents had a more positive attitude toward robots as equipment than as coworkers. Technology use self-efficacy and prior robot use experience were associated with more positive attitudes toward both robot positions. Having a degree in engineering or technology was associated with a positive attitude toward robot coworkers, while neuroticism was associated with a negative attitude. Additionally, technology use self-efficacy was found to have a significant indirect effect on the associations between openness and attitudes toward robots as well as conscientiousness and attitudes toward robots. In Study 2, a three-group online survey experiment showed that teleoperated robots and semi-autonomous robots were preferred as equipment over fully autonomous robots. The robots’ autonomy level did not impact attitude toward robot coworkers. Overall, the results suggest that people prefer non-autonomous robots over autonomous robots in the work-life context. The studies provide a comprehensive overview of attitudes toward robots as both equipment and coworkers, and the key predictors of the noted attitudes. The results suggest a readiness for shared autonomy between a human operator and a robot. This should be considered in the design and successful implementation of new robot technologies in workplaces.