bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dyadic analysis of adolescent friendships behaviours during pain: Comparison of those with chronic pain versus those without chronic pain
Authors: Forgeron Paula A. , Chambers Christine , Dick Bruce D. , Cohen Janice , Finley G. Allen , Lamontagne Christine 
Published: October 2021

AbstractBackgroundSocial context has been found to influence pain intensity and tolerance. The aims of this study were to determine the impact of one type of social context on the painful experiences of adolescents with and without chronic pain by examining interactions within and across friendship dyads during experimental pain.MethodsEach adolescent in 61 same‐sex friendship dyads (30 dyads with a chronic pain member) across three sites participated in the cold pressor task and acted as the observer during their friend's participation. They also completed a battery of measures to capture friendship features and pain outcomes. Pain intensity was measured using an 11‐point numeric scale. Pain tolerance was measured by the length of time in the cold pressor device. Videotapes of their interactions were coded for verbal and non‐verbal behaviours. A series of Actor Partner Independence Modelling, Hierarchical Multiple Regression and Multivariate Analysis of Covariance was used to analyse the data.ResultsFriendship features were not associated with pain intensity or tolerance. Both members of dyads with a chronic pain member used fewer non‐attending behaviours when they were observing their friend resulting in participants in those dyads having lower pain tolerance. Moreover, within dyads, one's friend's behaviours when experiencing pain influenced pain tolerance but only for those dyads with a chronic pain member.ConclusionsStrategies aimed at improving social interactions for adolescents with chronic pain while they are experiencing pain are discussed. Research is needed to understand how different peer relationships influence pain tolerance in adolescents with chronic pain.Significance of the researchDuring pain, patterns of interactions differ within and between adolescent friendship dyads when one has chronic pain (CP) versus controls. Dyads with a CP member use fewer non‐attending behaviours despite non‐attending behaviours rated as more helpful. Pain intensity was solely related to the participant's behaviour. Amongst dyads with a CP member, pain tolerance was also influenced by their friend's behaviours. Friends of adolescents with pain engage in more unhelpful behaviours perhaps decreasing the ability of CP adolescents to engage in social activities.
Experimentelle und numerische Untersuchungen zum Kompressionsverhalten von Sand‐Schluff‐Gemischen
Authors: Tafili Merita , Knittel Lukas , Gauger Vera 
Published: October 2021

AbstractDie Wahl eines geeigneten Stoffmodells für gemischtkörnige Böden ist für die Nachweisführung einer anspruchsvollen geotechnischen Konstruktion von entscheidender Bedeutung. Für die Entwicklung eines akkuraten Stoffmodells, ist wiederum die experimentelle Untersuchung des Bodens unabdingbar. Anhand von Ödometerversuchen an Mischungen mit unterschiedlichem Feinkornanteil wird das Kompressionsverhalten von Sand‐Schluff‐Gemischen untersucht. Hierbei zeigt sich, dass mit steigendem Feinkornanteil die Kompressibilität des Materials deutlich zunimmt, die jedoch unabhängig vom Feinkornanteil durch eine exponentielle Beziehung zwischen der äquivalenten Porenzahl e* und der vertikalen Dehnung beschrieben werden kann. Dabei wird das Verformungsgesetz von Ohde (1939) unter Berücksichtigung von e* auf Gemische verallgemeinert. Nachrechnungen mit dem hypoplastischen Stoffmodell für grobkörnige und dem AVISA‐Modell für feinkörnige Böden ergeben einen Bedarf für die Kopplung der Vorkonsolidierungsspannung und der Normalkonsolidierungslinie bei einem Verhältnis von 1 : 1 von Sand zu Schluff, abhängig vom Feinkornanteil.
The association between single and multiple chronic conditions and depression among older population in India: A comparative study between men and women
Authors: Meher Trupti , Muhammad Thalil , Gharge Shivani 
Published: October 2021

AbstractObjectiveThe study aimed to estimate the prevalence of depression and to explore the association of specific chronic conditions as well as multi‐morbidity with depression among the older population.MethodThe study utilized data from the Longitudinal Ageing Study in India Wave 1 (2017–2018). The total sample size for the present study was 31,464 older adults aged 60 and above, including 14,931 males and 16,533 females. Descriptive statistics along with bivariate and multivariate analyses were performed to fulfil the objectives.ResultsThe overall prevalence of depression among the elderly population in India was 8.7%. Older women had shown a greater prevalence rate of depression than older men. Among chronic conditions, hypertension, stroke, and bone‐related diseases were found to be significantly associated with depression in the case of both men and women. The prevalence of depression among older adults with three or more chronic conditions was higher in males (14.5%) than in females (11.2%). The association between the number of chronic conditions and depression exhibited a linear trend with an increased odds ratio indicating a higher risk of depression among older adults with multiple chronic conditions.ConclusionOlder individuals with a greater number of chronic illnesses have a higher risk of depression and the risk is proportional to the number of chronic conditions. This signifies the need for the identification of depressive symptoms at an early stage by focussing on the elderly suffering from chronic conditions and educating family members and the community about effective treatments and counselling.
Incorporating the Role(s) of Human Actors in Complex System Design for Safety and Security
Authors: Fleming Elizabeth S. , Williams Adam D. 
Published: October 2021

ABSTRACTTraditional systems engineering demonstrates the importance of customer needs in scoping and defining design requirements; yet, in practice, other human stakeholders are often absent from early lifecycle phases. Human factors are often omitted in practice when evaluating and down‐selecting design options due to constraints such as time, money, access to user populations, or difficulty in proving system robustness through the inclusion of human behaviors. Advances in systems engineering increasingly include non‐technical influences into the design, deployment, operations, and maintenance of interacting components to achieve common performance objectives. Such advances highlight the need to better account for the various roles of human actors to achieve desired performance outcomes in complex systems. Many of these efforts seek to infuse lessons and concepts from human factors (enhanced decision‐making through Crew Resource Management), systems safety (Rasmussen's “drift toward danger”) and organization science (Giddens' recurrent human acts leading to emergent behaviors) into systems engineering to better understand how socio‐technical interactions impact emergent system performance. Safety and security are examples of complex system performance outcomes that are directly impacted by varying roles of human actors. Using security performance of high consequence facilities as a representative use case, this article will outline the System Context Lenses to understand how to include various roles of human actors into systems engineering design. Several exemplar applications of this organizing lenses will be summarized and used to highlight more generalized insights for the broader systems engineering community.
Application of MBSAP to a Complex Problem with Social Dimensions: Utilization in Outpatient Imaging Centers
Authors: Speece Jill , Shahroudi Kamran Eftekhari 
Published: October 2021

ABSTRACTOutpatient imaging centers struggle daily to manage the negative impact of same day missed appointments. The technical component of outpatient imaging centers includes a complex IT infrastructure and advanced medical imaging equipment. The social component of outpatient imaging centers includes stakeholders that regularly interact with these technologies and one another all to help physicians diagnose their patients. The effectiveness of the technology used in outpatient imaging is dependent on operator ability and stakeholder collaboration. Problems in this type of system require intentional systems thinking to understand stakeholder needs. The Model‐Based System Architecture Process (MBSAP) provides a visually understandable framework for system development in an industry unfamiliar with Systems Engineering methods. The primary social dimensions in outpatient imaging are the Customer Dimension, Planning Dimension, Operations Dimension, and Technical Dimension. Each dimension has stakeholders with a diverse set of needs that must be well‐understood and incorporated into the requirements. This paper presents an architecture for a system that utilizes all available exam time slots without a dependency on modifying patient behavior to prevent same day missed appointments. The MBSAP artefacts are the starting point for making the system a reality with stakeholders and finding the right balance between separate social dimensional measures.
Serum exosomal long noncoding RNA CRNDE as a prognostic biomarker for hepatocellular carcinoma
Authors: Wang Ting , Zhu Hengkai , Xiao Min , Zhou Shao 
Published: October 2021

AbstractBackgroundAccumulating evidence has shown that long noncoding RNA (lncRNA) CRNDE functions as an oncogene in many cancer types. However, its clinical value has not yet been explored in hepatocellular carcinoma (HCC).MethodsA total of 166 patients with HCC and 100 healthy volunteers were enrolled in this study. The expression levels of serum exosomal lncRNA CRNDE were detected in patients with HCC and controls by quantitative real‐time PCR (qRT‐PCR).ResultsThe serum exosomal lncRNA CRNDE expression levels were significantly increased in patients with HCC compared with normal controls. High serum exosomal lncRNA CRNDE expression was significantly associated with tumor size, tumor differentiation, and TNM stage. Receiver operating characteristic (ROC) analysis revealed that an area under the ROC curve (AUC) of 0.839, with a sensitivity and specificity of 69.3% and 85.0%. In addition, the overall survival (OS) and disease‐free survival (DFS) were significantly longer in patients with lower serum exosomal lncRNA CRNDE expression compared to those with higher CRNDE expression. Moreover, HCC patients with cirrhosis had worse OS and DFS than those without cirrhosis. Univariate and multivariate analyses indicated that high serum exosomal lncRNA CRNDE expression was an independent indicator of poor prognosis.ConclusionTaken together, serum exosomal lncRNA CRNDE might serve as a potential biomarker for HCC diagnosis and prognosis.
Assessment of Transporter‐Mediated Drug Interactions for Enasidenib Based on a Cocktail Study in Patients With Relapse or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
Authors: Cheng Yiming , Wang Xiaomin , Tong Zeen , Reyes Josephine , Carayannopoulos Leon , Zhou Simon , Li Yan 
Published: October 2021

AbstractAs a first‐in‐class, selective, potent inhibitor of the isocitrate dehydrogenase‐2 (IDH2) mutant protein, enasidenib was approved by the US Food and Drug Administration in 2017 for the treatment of adult patients with relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase‐2 mutation. An in vitro study showed that enasidenib at clinically relevant concentrations has effects on multiple drug metabolic enzymes and transporters, including inhibition of P‐glycoprotein, breast cancer resistance protein, organic anion transporter (OAT) P1B1, and OATP1B3 transporters. Therefore, a drug‐drug interaction study was conducted to assess the impact of enasidenib at steady state on the pharmacokinetics of several probe compounds in patients with relapsed or refractory acute myeloid leukemia or myelodysplastic syndrome, including the probes herein described in this article, digoxin and rosuvastatin. Results from 8 patients (all Asian) with a mean age of 67.1 years showed that following coadministration of enasidenib (100 mg, 28‐day once‐daily schedule) for 28 days (at steady state), digoxin's (0.25 mg) area under the plasma concentration–time curve from time 0 to 30 days was 1.2‐fold (90% confidence interval, 0.9‐1.6), compared with digoxin alone. Following coadministration of enasidenib (100 mg, 28‐day once‐daily schedule) for 28 days (at steady state), rosuvastatin's (10 mg) area under the plasma concentration–time curve from time 0 to infinity was 3.4‐fold (90% confidence interval, 2.6‐4.5) compared with rosuvastatin alone. These results should serve as the basis for dose recommendations for drugs that are substrates of P‐glycoprotein, breast cancer resistance protein, OATP1B1, and OATP1B3 transporters, when used concomitantly with enasidenib.
Design and optimization of extractive distillation of benzene–n‐propanol with ionic liquid as entrainer
Authors: Li Wenxiu , Wang Lida , Zhang Yu , Feng Huisheng , Guo Hongfan , Zhang Tao 
Published: October 2021

AbstractBACKGROUNDThe binary benzene–n‐propanol azeotrope can be formed in chemical production. Extractive distillation is an important azeotrope separation technology and an ionic liquid is a type of excellent entrainer. Aspen Plus software was used to simulate the extractive distillation process. The separation performance of ionic liquids was evaluated in terms of total annual cost of the extractive distillation process. The separation mechanism of the azeotrope was quantitatively explained using intermolecular interaction energy.RESULTSThe thermodynamic properties databases of 1‐octyl‐3‐methylimidazolium acetate, trioctylmethylammonium acetate and 1‐decyl‐3‐methylimidazolium acetate were established in Aspen Plus software. The extractive distillation process was established through combining the thermodynamic properties of the three ionic liquids and the vapor–liquid equilibrium data of benzene–n‐propanol–ionic liquid. The optimal operating conditions were obtained by minimizing the total annual cost of the separation process through a sequential iterative method. The interaction energy was calculated using density functional theory through Gaussian 09 software and used to explain the principle of the benzene–n‐propanol azeotropic system separation.CONCLUSIONS1‐Octyl‐3‐methylimidazolium acetate has the best separation performance among the three ionic liquids. The interaction energy can be used to screen and design ionic liquids in the process of benzene–n‐propanol extractive distillation separation. © 2021 Society of Chemical Industry (SCI).
Signposts to decolonial futures in understanding and addressing our present crises
Authors: Pickren Graham W. , Pickren Wade E. 
Published: October 2021

AbstractWe introduce the special issue “Our Present Crises: Climate Change, Biodiversity Loss, and Social Inequality” by highlighting how histories of the social and behavioral sciences can contribute to a multifaceted understanding of the links among the climate crisis, massive biodiversity loss, and social and economic inequities of nearly every kind. We propose that although the epistemological and ontological bases of these disciplines are themselves entangled with modernity/coloniality, there are, nonetheless, critical insights to be gained by exposing these entanglements. These insights may help generate visions of decolonial futures which eschew destructive dualisms in favor of relational ontologies which honor the living ecosystem of the earth.
More remittances, fewer kids—Impact of remittances on fertility in Morocco
Authors: Ben Atta Oussama , Kasmaoui Kamal , Mughal Mazhar Yasin , Makhlouf Farid 
Published: October 2021

AbstractThis study examines the role played by remittances in Morocco's spectacular fertility decline over the 1975–2018 period. Using the autoregressive distributed lag (ARDL) bounds approach, we find a significant negative association between remittances to the country and total fertility rate. This relationship is stronger in the long term than in the short term, suggesting that the human capital‐accumulation channel is probably more important than the income effect. Findings of the study highlight the contribution of Morocco's large overseas migrant community to the country's demographic transition.
Iron deprivation restrains the differentiation and pathogenicity of T helper 17 cell
Authors: Li Lin , Xia Yuting , Yuan Shijie , Li Fei , Xie Xiaorong , Luo Yuan , Yang Xiang-Ping , He Ran 
Published: October 2021

AbstractIron plays a critical role in immune responses. However, its role in T helper cell differentiation and function remains poorly understood. In this study, it is shown that the restraint of iron availability through blocking CD71-mediated iron endocytosis impaired the differentiation and pathogenicity of TH17 cells. Administrations of anti-CD71 mAb could relieve the development of experimental autoimmune encephalomyelitis (EAE). Mechanistically, the iron deficiency due to the blocking of CD71 enhanced IL-2 expression, which further restrained the differentiation of TH17 cells. Meanwhile, CD71 blockade impaired histone modifications of Il17 gene and reduced the recruitment of RORγt to Il17a locus. In sum, the findings reveal that iron plays a pivotal role in regulating TH17 cell differentiation and function in autoimmune diseases.
Barriers of Chinese Gay Men to Counseling
Authors: Lin Chichun , Moore Darren D. , Espinoza Sandra A. , Nylund David 
Published: October 2021

This study explored Chinese gay men's barriers to counseling services through a basic interpretive qualitative methodology. Twelve participants attended interviews of 40 to 75 minutes in length. The found barriers were rooted in (a) practical obstacles, (b) limited information and worries, (c) cultural impacts, and (d) learned coping skills. The major limitations were from the participants' characteristics. The results can be used to optimize policies aimed at reducing barriers to counseling.Este estudio exploró las barreras que limitan el acceso de hombres gais chinos a servicios de consejería a través de una metodología cualitativa interpretativa básica. Doce participantes asistieron a entrevistas de entre 40 y 75 minutos de duración. Las barreras halladas tenían su origen en (a) obstáculos prácticos, (b) información limitada y preocupaciones, (c) impactos culturales y (d) habilidades de afrontamiento aprendidas. Las características de los participantes causaron las mayores limitaciones. Se pueden usar los resultados para optimizar las políticas orientadas a la reducción de barreras a la consejería.
Relationship between the development of a convective mixed layer and dust weather in arid and semi‐arid regions of East Asia
Authors: Nakamae Kumi , Takemi Tetsuya 
Published: October 2021

AbstractMineral dust affects global and regional climates through radiative forcing. Herein the relationship between convective mixed layers and dust weather over arid and semi‐arid regions in East Asia is statistically analysed using operational surface‐station observation data and the lifting condensation level (LCL) height as a substitute for the mixed layer height. We divided the East Asia area into five regions (west/east Taklamakan Desert, west/east Gobi Desert and northeast China) and classified dust weather into three categories (floating dust, blowing dust and dust storm). Floating dust is the most frequent in the west Taklamakan Desert. All dust weather types are observed in the Taklamakan Desert even at low wind speeds but are seldom observed if the daily maximum LCL height is less than about 1,000 m. The floating dust events observed inside the Tarim basin seem to spread widely. In the Gobi Desert, when the maximum LCL height reaches about 3,000 m, all the dust weather types spread within the region. In all regions, the daily maximum LCL heights are higher in dust weather categories than in the no‐dust weather category. When a severe dust weather is observed in the Taklamakan and Gobi Deserts, the daily maximum LCL height reaches around 4,000–5,000 m above the mean sea level under higher wind conditions, suggesting that dust particles are easily raised from the boundary layer into the free troposphere during dust events in well‐developed mixed layer conditions. In the Gobi region, the frequency and areal extent of the blowing dust and the dust storm are higher than those of the floating dust. Therefore, the role of the deep mixed layers in the Gobi Desert is more important than that in the Taklamakan Desert.
Optimization of Process‐Control Parameters for the Diameter of Electrospun Hydrophilic Polymeric Composite Nanofibers
Authors: Alfares Fawzan S. , Guler Ece , Alenezi Hussain , Cam Muhammet Emin , Edirisinghe Mohan 
Published: October 2021

AbstractA composite nanofiber composed of three polymers, namely polyvinyl alcohol/polyvinyl pyrrolidone/polyethylene oxide, is produced. The experiments are constructed using three design of experiment techniques, Taguchi L9, Taguchi L27, and Screening method. The experiments are verified using the analysis of variance (ANOVA) method and later a mathematical model is developed using the regression method. The impact of electrospun processing parameters, namely applied voltage, flow rate, and working distance, on nanofibers' diameter is measured. The working distance is a significant factor in controlling the size of the fiber diameter, while the applied voltage has the lowest effect on it. As a result of the regression equation, a Genetic algorithm is used to find the optimum variables for the required fiber diameter, which is 156 nm for flow rate = 0.001 mL h−1, voltage = 30 kV, and distance = 200 mm with a 3% difference from the experimental fiber diameter.
Genetic Stratification of Age‐Dependent Parkinson's Disease Risk by Polygenic Hazard Score
Authors: Pihlstrøm Lasse , Fan Chun C. , Frei Oleksandr , Tan Manuela , Karunamuni Roshan A. , Blauwendraat Cornelis , Bandres‐Ciga Sara , Gan‐Or Ziv , Grosset Donald G. ,   International Parkinson's Disease Genomics Consortium (IPDGC), Dale Anders M. , Seibert Tyler M. , Andreassen Ole A. 
Published: October 2021

AbstractBackgroundParkinson's disease (PD) is a highly age‐related disorder, where common genetic risk variants affect both disease risk and age at onset. A statistical approach that integrates these effects across all common variants may be clinically useful for individual risk stratification. A polygenic hazard score methodology, leveraging a time‐to‐event framework, has recently been successfully applied in other age‐related disorders.ObjectivesWe aimed to develop and validate a polygenic hazard score model in sporadic PD.MethodsUsing a Cox regression framework, we modeled the polygenic hazard score in a training data set of 11,693 PD patients and 9841 controls. The score was then validated in an independent test data set of 5112 PD patients and 5372 controls and a small single‐study sample of 360 patients and 160 controls.ResultsA polygenic hazard score predicts the onset of PD with a hazard ratio of 3.78 (95% confidence interval 3.49–4.10) when comparing the highest to the lowest risk decile. Combined with epidemiological data on incidence rate, we apply the score to estimate genetically stratified instantaneous PD risk across age groups.ConclusionsWe demonstrate the feasibility of a polygenic hazard approach in PD, integrating the genetic effects on disease risk and age at onset in a single model. In combination with other predictive biomarkers, the approach may hold promise for risk stratification in future clinical trials of disease‐modifying therapies, which aim at postponing the onset of PD. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society