bluuebunny/crossref_metadata_2025_split huggingface dataset:
Choosing the Right Treatment Option for the Right R/M HNSCC Patient: Should We Adhere to PFE for First-Line Therapy?
Authors: Lübbers Katharina , Pavlychenko Mykola , Wald Theresa , Wiegand Susanne , Dietz Andreas , Zebralla Veit , Wichmann Gunnar 
Published: July 2021

BackgroundThe landmark EXTREME trial established cisplatin, 5-fluorouracil and cetuximab (PFE) as first-line chemotherapy (1L-ChT) for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). We were interested in outcome differences of R/M HNSCC in 1L-ChT and factors influencing outcome in certain subgroups, especially patients receiving PFE, and the value of PFE compared to other 1L-ChT regimens to provide real world evidence (RWE).MethodsFor this retrospective monocentric study, 124 R/M HNSCC patients without curative surgical or radiotherapy options receiving at least one cycle of 1L-ChT were eligible. We analyzed their outcome using Kaplan-Meier plot and Cox regression to identify predictors for prolonged survival.ResultsSubgroups benefiting significantly from PFE were patients suffering from an index HNSCC outside the oropharynx. The PFE regimen proved to be superior to all other 1L-ChT regimens in clinical routine. Significant outcome differences between PFE treatment within or outside controlled trials were not seen.ConclusionThis retrospective analysis provides RWE for factors linked to improved outcome. Subgroup analyses highlight the lasting value of PFE among the growing spectrum of 1L-ChT. Importantly, fit smokers with high level alcohol consumption benefit from PFE; considering the patient’s lifestyle factors, PFE should not be ignored in decision-making.
Melphalan as a Promising Treatment for BRCA-Related Ovarian Carcinoma
Authors: Conteduca Vincenza , Scarpi Emanuela , Farolfi Alberto , Brighi Nicole , Rossi Lorena , Gurioli Giorgia , Lolli Cristian , Schepisi Giuseppe , Bleve Sara , Gianni Caterina , Virga Alessandra , Altavilla Amelia , Burgio Salvatore Luca , Menna Cecilia , De Giorgi Ugo 
Published: July 2021

IntroductionMelphalan, as a bifunctional alkylating agent has been shown to be selectively efficient in BRCA-deficient case reports of epithelial ovarian cancer (EOC). The clinical benefit of melphalan on unselected platinum-resistant EOC population and stratified by BRCA status has not been clearly elucidated. We aimed to determine the response to melphalan in patients with recurrent EOC after platinum-based therapy.Material and MethodsThis retrospective observational study included patients with recurrent EOC treated with melphalan between February 2007 to July 2020. Eligibility criteria included having a histological confirmation of EOC, previous treatment with carboplatin plus paclitaxel regimens, and disease recurrence during treatment with or within 6 months of the end of the platinum-based chemotherapy.ResultsA total of 75 platinum-resistant EOC patients were enrolled. Median age was 69 years (range 41-82). Median of previous therapies before melphalan was 4 (range 1-7). We observed a median follow-up of 32 months (range 1-62), progression-free survival (PFS) and overall survival (OS) of 3.6 months (range 2.9-4.7) and 9.5 months (range 8.0-14.1), respectively. In the whole population, 1 complete response, 6 partial responses and 37 stable diseases were registered with an overall clinical benefit rate of 58.7%. In BRCA1/2 mutant patients, we showed a significant longer PFS compared to BRCA1/2 wild type patients (6.2 versus 2.6 months; hazard ratio (HR) 0.25, 95% confidence interval (CI) 0.10-0.61; p=0.002). Moreover, a trend was seen for BRCA1/2 mutants to have a better OS (25.9 versus 8.0 months; HR 0.38; 95% CI 0.12-1.19; p=0.097).ConclusionsOur study represents the largest cohort of heavily-pretreated EOC patients receiving melphalan treatment. Here, we report a considerable clinical activity of melphalan chemotherapy, more evident in a subset of BRCA1/2 mutated patients. Prospective studies to validate these findings are warranted.
Fathers Matter: Enhancing Healthcare Experiences Among Fathers of Children With Developmental Disabilities
Authors: Ogourtsova Tatiana , O'Donnell Maureen E. , Chung Derrick , Gavin Frank , Bogossian Aline , Majnemer Annette 
Published: July 2021

Background: Being a parent of a child with a developmental disability (DD; e. g., cerebral palsy, autism) comes with great challenges and apprehensions. Mothers and fathers of children with DD are experiencing heightened levels of psychological distress, physical health problems, financial difficulties, social isolation, and struggles with respect to traditional parenting roles. In relation to the latter, the involvement of fathers in caregiving in today's society is increasing and is highlighted by its importance and positive contribution to the development of their children. However, fathers of children with DD report feeling excluded and marginalized by healthcare providers (HCPs) when arranging for and getting involved in healthcare services for their children. Currently, there is limited evidence as to what factors influence those experiences. We aimed to explore barriers to and facilitators of positive and empowering healthcare experiences, from the perspectives of fathers of children with DD and HCPs.Methods: A mixed-method approach, such as quantitative (survey) and qualitative (semi-structured interview) strategies, was used. Participants were fathers of children with DD and HCPs working in childhood disability. Data analysis consisted of using descriptive statistics and an inductive-thematic analysis of emergent themes.Results: Fathers (n = 7) and HCPs (n = 13, 6 disciplines) participated. The fathers indicated that while they were moderate to very much satisfied with their interactions with HCPs, they reported that HCPs were only sometimes attentive to them during interactions. Fathers also revealed that positive interactions with HCPs in relation to their children had multiple benefits. Several themes related to barriers and facilitators of optimal interactions and parent–professional relationships emerged. These included session factors (time, attention), personal factors (knowledge of the condition, child and healthcare system, acceptance vs. denial, previous experiences, culture, stereotypes, pre-existing beliefs, stress levels, working schedule), and family dynamics. The participants offered several insights into the different strategies that can be implemented to promote optimal interactions between fathers and HCPs.Conclusion: We identified several barriers, facilitators, and improvement strategies for optimal interactions and enhanced parent–professional relationships from the perspectives of fathers and HCPs. These can be integrated by existing clinical settings in efforts to enhance current clinical practices and improve child- and parent-related outcomes.
Synthesis and Antiparasitic Activity of New Conjugates—Organic Drugs Tethered to Trithiolato-Bridged Dinuclear Ruthenium(II)–Arene Complexes
Authors: Desiatkina Oksana , Johns Serena K. , Anghel Nicoleta , Boubaker Ghalia , Hemphill Andrew , Furrer Julien , Păunescu Emilia 
Published: July 2021

Tethering known drugs to a metalorganic moiety is an efficient approach for modulating the anticancer, antibacterial, and antiparasitic activity of organometallic complexes. This study focused on the synthesis and evaluation of new dinuclear ruthenium(II)–arene compounds linked to several antimicrobial compounds such as dapsone, sulfamethoxazole, sulfadiazine, sulfadoxine, triclosan, metronidazole, ciprofloxacin, as well as menadione (a 1,4-naphtoquinone derivative). In a primary screen, 30 compounds (17 hybrid molecules, diruthenium intermediates, and antimicrobials) were assessed for in vitro activity against transgenic T. gondii tachyzoites constitutively expressing β-galactosidase (T. gondii β-gal) at 0.1 and 1 µM. In parallel, the cytotoxicity in noninfected host cells (human foreskin fibroblasts, HFF) was determined by an alamarBlue assay. When assessed at 1 µM, five compounds strongly impaired parasite proliferation by >90%, and HFF viability was retained at 50% or more, and they were further subjected to T. gondii β-gal dose-response studies. Two compounds, notably 11 and 13, amide and ester conjugates with sulfadoxine and metronidazole, exhibited low IC50 (half-maximal inhibitory concentration) values 0.063 and 0.152 µM, and low or intermediate impairment of HFF viability at 2.5 µM (83 and 64%). The nature of the anchored drug as well as that of the linking unit impacted the biological activity.
O mundo como alvo
Authors: Arantes Paulo Eduardo 
Published: July 2021

Faz algum tempo que vivemos em um mundo povoado de alvos. Somos inclusive alvos de um sem-número de empreendimentos, dos mais inocentemente comerciais às mais turvas operações encobertas. Uma simples consulta ao Google, não por acaso uma máquina colossal de “obter alvos”, deverá exibir com certeza alguns milhões de ocorrências, na grande maioria das línguas que operam nesse mesmo mundo coberto de alvos. Alguma coisa esta inflação deve dizer sobre a sociedade em que vivemos e a direção em que está indo. Mais de um autor está respondendo que nos anos que correm estamos entrando numa sociedade de direcionamento de alvos, como recentemente se traduziu targeted societies. Nesse meio tempo, um outro teórico mostrou que vivíamos há um bom tempo numa era em que o próprio mundo havia se tornado ele mesmo um alvo. Como não dá para enfrentar sem mais, por assim dizer em campo aberto e meramente conceitual, a hipótese de que passamos a viver, para além da disciplina e do controle, tal como os tratam Foucault e Deleuze, respectivamente, numa sociedade de alvos direcionados, podemos começar por um rodeio, para testar por nossa vez uma outra variante dessa mesma hipótese, a de que a sociedade de alvos direcionados em que nos debatemos é ela mesma o ponto de acumulação de um longo processo de definição militar da realidade. Se conseguirmos igualmente sugerir que o assim chamado capitalismo de vigilância se explicaria em alguma medida pela expansão daquele mesmo processo de definição da realidade, teremos quem sabe atinado com a nota específica da espantosa guerra dos mundos que se trava à nossa volta. Para resumir de outro modo essa visão do mundo como alvo, diremos que também se trata de uma hipótese alternativa sobre a militarização contemporânea.

Palavras-chave: era atômica, era da emergência, antropoceno, público-alvo, bombardeio estratégico, militarização, dispositivos de segurança, capitalismo de vigilância, metafísica militar, Wright Mills, Veblen, Adorno, Virilio, targeted society.
Esquerda e direita no espelho das ONGs
Authors: Arantes Paulo Eduardo 
Published: July 2021

Paulo Arantes problematiza neste conhecido artigo o léxico "dos direitos da cidadania" que tem sido utilizado por autoridades governamentais vinculadas à área social e por empresas – um sistema de simulacros, uma vez que enseja a mistura dos papéis e camufla os reais interesses dos segmentos sociais envolvidos, num jogo de "coisas trocadas". Exemplos do linguajar, oriundo de ONGs, são as expressões "sociedade civil", "espaços sociais", "compromisso" e "envolvimento" entre os "atores", conduzindo a uma "participação cidadã". Da órbita empresarial, provêm "vivência empresarial", "cumplicidade", "envolvimento com o seu entorno", "parceiros" e "interlocutores no mercado", "empresa cidadã". Esse léxico integra o corpo das políticas compensatórias recomendadas pelos patrocinadores da reestruturação econômica e social em curso, tendo o Banco Mundial à frente. Nesse arcabouço de mudanças, está incluída uma nova concepção do papel do Estado, com enxugamento de parcela específica de suas funções, principalmente aquela de executor das políticas sociais, engendradas sob a égide do keynesianismo. A concretização dessas políticas passa a ser delegada a "parceiros da sociedade civil", entidades sem fins lucrativos, contando com repasses de verbas públicas. (...) Advoga-se o lugar de um Terceiro Setor gerencialmente enxuto, um Estado parceiro-facilitador que deve "estrategicamente" se retirar assim que as organizações não governamentais "demonstrarem" a superioridade de suas vantagens comparativas, uma vitória sem muito esforço, já que não havia mais em campo com quem competir, salvo a sucata preparada para tal efeito demonstrativo. Quanto às empresas, Paulo identifica presentemente a existência de "um surto esquizofrênico, pois agem, mas sobretudo falam, dando a entender que no fundo são organizações sociais sem fins lucrativos", sem, de fato, perderem a veia comercial que lhes é intrínseca. As empresas capitalizam o trabalho "voluntário" que induzem seus empregados a fazer junto às "comunidades", transformando-o em vantagem competitiva, mediante a agregação da imagem de "empresa cidadã" aos produtos e/ou serviços que colocam no mercado. O fenômeno pode ser resumido pela utilização distorcida das palavras que denomina, utilizando expressão de Vera da Silva Telles, "espantoso deslizamento semântico", contextualizando-o e denunciando sua intenção de colocar o mundo "de ponta-cabeça", de enevoar a consciência, de confundir. Esse léxico cumpre, portanto, as funções da ideologia, procurando encobrir a desigualdade na distribuição da riqueza e do poder no interior da sociedade capitalista.
(Da resenha de Maria Rosa Lombardi)

Palavras-chave: ONG, reforma do Estado, empresa-cidadã, sociedade civil, terceiro setor, organizações sociais, Banco Mundial, parcerias, direitos da cidadania, marketing, público-alvo, lógica gerencial, empoderamento, privatização, linguagem, deslizamento semântico.
SOCIAL CONSEQUENCES OF FALSIFICATION OF SCIENTIFIC MATERIALS IN ELECTROMAGNETIC SAFETY
Authors: СПОДОБАЕВ Ю.М. 
Published: July 2021

Рассматривается проблема социально-психологических механизмов поведенческих реакций населения, которая становится все актуальнее в связи с ростом социальной напряженности из-за размещения излучающих объектов современных сетевых технологий и обострением радиофобии. В качестве провоцирующего подобные ситуации фактора выделяется информационный фактор, т.е. доведение до населения результатов научно-технического и медико-биологического обоснования электромагнитной безопасности объектов связи. Приводится пример искажений и фальсификации научных результатов медико -биологических исследований, являющихся основой нормативной и методической документации. Названы социальные последствия проблемы, суть которых в том, что не просто растет недоверие специалистов и населения к системе санитарногигиенического контроля, а более того, ставится под сомнение безопасность современных технологий в целом.
The problem of socio-psychological mechanisms of behavioral reactions of the population is considered, which is becoming more and more relevant due to the growing scale of social tension around radiating objects of modern network technologies and progressive radiophobia of the population. The information factor is highlighted as a factor provoking such situations, i.e. bringing to the public the results of scientific, technical, and medico-biological justification of the electromagnetic safety of communication facilities. The example of distortion and falsification of scientific results of biomedical research, which are the basis of normative and methodological documentation, is given. The social consequences of the problem are named, the essence of which is that not only the distrust of specialists and the population to the system of sanitary and hygienic control is growing, but the safety of modern technologies, in general, is being questioned.
PREDICTION METHOD OF SDN CONTROLLERS LOADING BASED ON THE ARTIFICIAL INTELLIGENCE TECHNOLOGIES
Authors: ВОЛКОВ А.Н. , КУЧЕРЯВЫЙ А.Е. 
Published: July 2021

Предложен подход к прогнозированию нагрузки на контроллеры SDN, основанный на алгоритмах искусственного интеллекта и полном мониторинге активности служебных каналов OpenFlow. Дано обоснование возможности прогнозирования нагрузки на аппаратную часть контроллера с помощью анализа метаданных служебных потоков OpenFlow.
A novel method for SDN controllers load prediction based on artificial intelligence algorithms and total monitoring of OpenFlow channel activity is proposed. The justification for predicting the load on the hardware part, with the help of OpenFlow flows metadata analytics is given.
REDUCING THE COMPUTATIONAL COMPLEXITY OF SIGNAL DETECTION IN MIMO SYSTEMS
Authors: БАКУЛИН М.Г. , БЕН РАЖЕБ Т.Б.К. , КРЕЙНДЕЛИН В.Б. , СМИРНОВ А.Э. 
Published: July 2021

С развитием технологии MIMO и появлением технологии massive MIMO возросла сложность обработки сигнала на приемной стороне. Применение известных алгоритмов детектирования сигнала на приемной стороне становится трудно реализуемым из-за высокой вычислительной сложности. Предлагается новая реализация известного алгоритма МСКО, которая позволяет снизить вычислительную сложность детектирования без потерь в помехоустойчивости в системах беспроводной связи, использующих технологию massive MIMO.
With the development of MIMO technology and the appearance of the massive MIMO technology, the computational complexity of signal processing on the receiving side has increased. The application of known signal detection algorithms used in MIMO systems becomes difficult or even impossible to implement in massive MIMO systems because of computational complexity. We offer a new realization technique of the well-known MMSE detection algorithm with less computational complexity and without any loss in noise immunity in wireless communication systems using massive MIMO technology.
MODELING THE NETWORK STRUCTURE OF THE IoT USING FRACTALS
Authors: ТОНКИХ Е.В. , ПАРАМОНОВ А.И. , КУЧЕРЯВЫЙ А.Е. 
Published: July 2021

В работе представлен метод планирования структуры сети интернета вещей на основе использования фракталов. Предлагается применять фрактальные фигуры для описания структуры целевого окружения, которое определяет размещение сетевых устройств. Для планирования используются значения оценки фрактальной размерности и доли площади, занимаемой целевым окружением и моделью сети. Полученные результаты могут быть использованы при планировании структуры сети интернета вещей в городской или иной среде на основе данных, полученных о целевом окружении в виде планов, карт или фотоснимков.
The paper proposes a method for planning the structure of the I nternet of Things network based on the use of fractals. It is proposed to use fractal figures to describe the target environment, which determines the placement of network devices. The values of the estimate of the fractal dimension and the fraction of the area occupied by the target environment and the network model are used for planning. The results obtained can be used to describe the structure of the IoT network in an urban or other environment based on data obtained about the target environment in the form of plans, maps, or photographs.
MONITORING AND CERTIFICATION OF FIBER-OPTIC INFRASTRUCTURE BASED ON INTERFEROMETRIC MEASUREMENTS
Authors: СТАРОДУБЦЕВ Ю.И. , ИВАНОВ С.А. , СМИРНОВ И.Ю. 
Published: July 2021

Показано усложнение процесса управления волоконно-оптической инфраструктурой, обусловленное ростом связности сети, увеличением количества элементов систем связи, ростом количественных и качественных показателей оптического кабеля. При усложнении объекта управления требуется увеличить объем достоверной информации для характеристики его текущего состояния. Предлагается на всех уровнях управления результатами измерения использовать средства, реализующие интерферометрические методы и их сведение в единую базу данных, структура которой обоснована в статье. Данное решение направлено на повышение оперативности принятия адекватного решения по управлению инфраструктурой на всех уровнях управления.
The article shows the complication of the process of fiber-optic infrastructure management due to the growth of network connectivity, the increase in the number of elements of the communication system, and the growth of quantitative and qualitative indicators of the optical cable. When the control object is complicated, it is required to increase the volume of reliable information to characterize its current state. At all levels of management of measurement results, it is proposed to use tools that implement interferometric methods and their consolidation into a single base, the structure of which is justified in the article. The proposed solution is aimed at increasing the efficiency of making an adequate decision on infrastructure management at all levels of management.
SYNCHRONIZATION IN TIME-DUPLEX RADIO SYSTEMS
Authors: БОКК Г.О. , АВЕРЬЯНОВ Р.С. 
Published: July 2021

Рассмотрена работа в режиме синхронизации системы связи стандарта МАКВИЛ, использующей организацию радиосвязи с временным дуплексом. Получен базовый вариант оптимального алгоритма обработки одиночных замеров син -хронизации, ориентированный на работу в канале с белым гауссовским шумом при неизвестных, но стабильных спектральных искажениях сигнала. На основе разработанного алгоритма предложено множество вариантов статистического накопления измерений для режима синхронизации в нестационарных условиях. На моделях многолучевого распространения, утвержденных международными рекомендациями, выявлены наилучшие варианты алгоритмов синхронизации с накоплением.
Operation in synchronization mode of the McWiLL standard communication system, using the organization of radio communication with time duplex, is considered. A basic version of the optimal algorithm for processing single synchronization measurements is obtained, which is focused on working in a channel with white Gaussian noise at unknown but stable spectral distortions of the signal. Based on the developed algorithm, many variants of statistical accumulation of measurements for the synchronization mode in non-stationary conditions are proposed. Using multipath propagation models approved by international recommendations, the best variants of synchronization algorithms with accumulation are identified.
THE USE OF NEAR-EARTH ORBITS BY SATELLITE SYSTEMS IN DIFFERENT FREQUENCY BANDS
Authors: ВАРЛАМОВ Н.В. , УВАРОВ С.С. 
Published: July 2021

Выполнен анализ интенсивности использования геостационарной орбиты (ГСО) и негеостационарных орбит (НГСО) современными системами спутниковой связи фиксированной спутниковой службы в Ки-, Ка- и Q/V-диапазонах частот. Исследование охватывает ГСО, а также два наиболее используемых сегмента НГСО с высотой апогея до 1500 км и выше 8000 км. Представлены также результаты исследований для высокоэллиптических орбит (ВЭО). Сделан вывод о дефиците орбитально-частотного ресурса на ГСО и НГСО для рассматриваемых диапазонов частот.
The paper analyzes the intensity of the use of geostationary orbit (GSO) and non-geostationary orbits (non-GSO) by modern satellite communication systems of the fixed-satellite service in the Ku-, Ka- and Q/V-bands. The analysis is made for geostationary orbit and two most used segments of non-GSO orbits with apogee altitudes up to 1500 km and above 8000 km. Results for highly inclined elliptical orbits (HEO) are also presented. The analysis results show a shortage of orbital and frequency resources in GSOs and non-GSOs for the considered frequency bands.