bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Nomogram To Predict The Cumulative Live Birth Rate for Patients with Low Prognosis According To The POSEIDON Criteria: A Retrospective Observational Cohort Study of 4,395 Patients in Chinese Population
Authors: Chen Lijuan , Qu Pengfei , Wu Jinfang , Xie Jinlin , Wang Hui , Shi Wenhao , Shi Juanzi 
Published: August 2021

Abstract
Purpose

A small number of risk prediction model have been previously reported to predict the infertility treatment success. While the studies of the risk prediction model for the patients with low prognosis are limited. This study aimed to construct and validate a nomogram for the prediction of cumulative live birth rate (CLBR) in patients with low prognosis from a single center database in Chinese population.
Methods

Clinical data of 4,395 patients with low prognosis, who received in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) therapy between 2014 and 2018, were retrieved and randomly divided into training (70%) and the external validation (30%) sets. Multivariate analysis with logistic regression model was conducted.
Results

Multivariate analyses showed that maternal age, body mass index (BMI), basal serum follicle-stimulating hormone (FSH) level, type of infertility, male factors, uterine factors, and usable embryos number at day 3 were risk factors for CLBR in patients with low prognosis. The area under the receiver operating characteristic curve (AUC) of the prediction model was 0.769 (95% confident interval (CI): 0.751, 0.787) in training set. The validation set presented good performance with an AUC of 0.749 (95% CI: 0.720, 0.778). In addition, Hosmer-Lemeshow chi-square value was 10.194 (P = 0.252).
Conclusion

We constructed and validated a nomogram for the prediction of CLBR in low prognosis patients with a single center database in Chinese population. The validated nomogram for the prediction of CLBR could be potentially applied in clinic for IVF counselling in patients with low prognosis.
Proposal for Modifications to the Bangkok Urban Health System that would Improve the Quality of Health, Independent Living, and Maintenance of Older Adults with Fall-related Trauma (Bangkok Falls Study)
Authors: Sri Jiraporn , Kredarunsooksree Thiti , Paksophis Thitiwan , Rojtangkom Khemika , Rojsaengroeng Rapeeporn , Vanichkulbodee Alissara , Fusakul Yupadee , Ruangsiri Rasida 
Published: August 2021

Abstract
BackgroundThe Bangkok falls study aimed to identify fall-associated factors, including home healthcare hazards, nutritional status, hydration status, sarcopenia, frailty, locomotive syndrome, and health status of urban older adults in a middle-income country.Methods This was a population-based cohort study that enrolled adults who lived in Bangkok, Thailand. Our study recruited older adults aged ≥ 60 years old, able to walk, and expected to live in the community for at least 2 years. The study had three phases included; phase 1: subject identification and terminology clarification. Phase 2: we collected data at community sites on baseline characteristic and fall risk identification. Examinations and laboratory investigations were scheduled for one month later. Phase 3: telephone follow up for falls rate, functional status and death at 3, 6, 12 months.Results A total 1,001(51.84%) people were enrolled for our study. The average age of our study was 69.9 years old (SD, 6.8), and two-thirds were female. Using “Stopping Elderly Accidents, Death and Injuries” (STEADI) screening fall risk, our study found that 37.7% had scores ≥ 4, which means that there is a risk of fall. In addition, the risk of falls increased among older adults aged 75–84 years (49.5%) and older adults aged ≥ 85 years (67.7%) (P-value < 0.001).ConclusionThis study demonstrated the feasibility of conducting a population-based cohort study among urban older adults in a middle-income country using the local community healthcare system. Our study have a tendency to provide data source for fall risk factors and disability in older adults.
The Clinical And Prognostic Value of NLR, PDW, And PNI In Advanced Non-Small-Cell Lung Cancer Treated With Platinum-Based Chemotherapy
Authors: Wang Jian , Liu Yiqian , Wang Guoqing , Shao Mengting , Mi Xiaoguang , Yin Xingxing , Wang Teng , Liu Lingxiang 
Published: August 2021

Abstract
Objective: The purpose of this study was to investigate the relationship between the neutrophil-lymphocyte ratio (NLR), platelet distribution width (PDW) and prognostic nutrient index (PNI), and the prognosis of patients with advanced non-small-cell lung cancer (NSCLC) treated with platinum-based chemotherapy.Methods: A total of 428 patients with advanced NSCLC treated with platinum-based chemotherapy between January 2015 and June 2019 were retrospectively analyzed. The patients were randomly divided into training set (n=300) and test set (n=128) in a ratio of 7:3, respectively. Clinical data and peripheral blood test results were collected within one week prior to the initiation of treatment to calculate PDW, NLR, and PNI. Receiver operating characteristic (ROC) curves were used to determine the optimal cut-off values of PLR, PDW, and PNI. Kaplan-Meier method and Cox regression analysis were used to evaluate the prognostic factors of advanced NSCLC treated with platinum-based chemotherapy. A Nomogram model was established for predicting the prognosis in advanced NSCLC treated with platinum-based chemotherapy. The test set was used for external validation of the prognostic model.Results: There was no significant difference in the proportion of clinical features between the training set and the test set (P＞0.05). The ROC curve analysis determined the optimal cut-off values of PLR, PDW, and PNI to be 3.07, 16.81, and 52.025, respectively. Univariate and multivariate analyses indicated that tumor type (P=0.038), tumor differentiation (P=0.014), NLR (P=0.001), PDW (P<0.001), and PNI (P=0.009) were independent prognostic factors for PFS in patients with advanced NSCLC patients treated with platinum-based chemotherapy. Tumor type (P=0.002), tumor differentiation (P=0.038), EGFR status (P=0.002), NLR (P=0.010), PDW (P=0.001), and PNI (P=0.002) were independent prognostic factors for overall survival (OS) in advanced NSCLC patients treated with platinum-based chemotherapy. The established nomogram was validated internally and externally. The results showed a good agreement between the predicted value and the actual value of the calibration curve.Conclusion: NLR, PDW, PNI, tumor type, and tumor differentiation are independent prognostic factors for PFS in advanced NSCLC patients treated with platinum-based chemotherapy. NLR, PDW, PNI, tumor type, tumor differentiation, and EGFR status are independent prognostic factors for OS in advanced NSCLC patients treated with platinum-based chemotherapy. The established model has an application value in predicting the prognosis of advanced NSCLC patients treated with platinum-based chemotherapy.
Low Mg Content on Ti-Nb-Sn Alloy When in Contact with BMMSCs Promotes Improvement of its Biological Functions
Authors: Dias Carolina da Silva , Rossi Mariana Correa , Apolonio Emanuel V. P. , Rosa Gustavo dos Santos , Pfeifer João Pedro Hübbe , Hussni Carlos Alberto , Watanabe Marcos Jun , Alves Ana Liz Garcia 
Published: August 2021

Abstract
Introduction: Magnesium is a metal used in the composition of titanium alloys and imparts porosity. Due to its osteoconductive, biocompatible and biodegradable characteristics, its application in the development of biomedical materials has become attractive.Objective: This study aimed to evaluate the influence of magnesium present in porous Ti-Nb-Sn alloys, which have a low elastic modulus in adhesive, osteogenic properties and the amount of reactive intracellular oxygen species released in mesenchymal stem cells derived from bone marrow equine bone (eBMMSCs).Methods: Mechanical properties of the alloy, such as hardness, compressive strength and elastic modulus, were analyzed, as well as surface morphological characteristics through scanning electron microscopy. The evaluation of magnesium ion release was performed by atomic force spectroscopy. The biological characteristics of the alloy, when in contact with the alloy surface and with the culture medium conditioned with the alloy, were studied by SEM and optical microscopy. Confirmation of osteogenic differentiation by alizarin red and detection of ROS using a Muse® Oxidative Stress Kit based on dihydroetide (DHE).Results and discussion: The alloy showed an elastic modulus close to cortical bone values. The hardness was close to commercial Ti grade 2, and the compressive strength was greater than the value of cortical bone. The eBMMSCs adhered to the surface of the alloy during the experimental time. Osteogenic differentiation was observed with the treatment of eBMMMSCs with conditioned medium. The eBMMSCs treated with conditioned medium decreased ROS production, indicating a possible antioxidant defense potential of magnesium release.
A Pilot Study Using Nanoparticles and Laser Induced Photothermal Ablation to Treat Low Grade Canine Mast Cell Tumors: Evaluation of Efficacy and Safety
Authors: Parshley Lisa , Miller Lisa A. , Taboada Luis , Tripp Chelsea , Gustafson Scott , Bradley Abbey , Melton Tammy , Sitzman Shane , Pape Evan , Mouat Emily , Rosenfeld Andrew 
Published: August 2021

Abstract
Background: Nanoparticles for over forty years have been the subject of a large number of physical and bioscience research. In the last decade use of these particles in medicine has gone from theoretical to clinical trials. Passive targeting of metal-based nanoparticles takes advantage of inherent abnormalities in tumor vasculature allowing accumulation in solid tumors through a process known as the ‘‘enhanced permeability and retention’’ (EPR) effect. In animal tumor implant models, combination of gold and silicone nanoparticle (GSN) and exposure of tumors to laser light (at 808nm) generated enough heat to cause tumor cell death. Mast cell tumors (MCT) are the most common skin tumor in dogs, with an estimate of MCT being roughly 20% of canine skin tumors. The goal of this pilot study is to evaluate nanoparticle and laser tumor thermal ablation on low grade canine MCT model.Results: 38 dogs with 44 mast cell tumors were enrolled in this prospective pilot study. All control tumors and those biopsied prior to laser therapy were found to be low grade MCT by histopathology (two grade method). After random number generation 8 dogs were assigned to control group and 30 dogs were assigned to treatment group. Treatment group had 36 total tumors and control group had 8 tumors present at time of enrollment. Treatment dogs had a 100% response rate, with 94% achieving clinical remission (34 tumors). Recurrence rate was 17% in those tumors achieving clinical remission. Mean progression free time (PFT) for the treatment group was 552 days and mean PFT for the control group was 1095 days.Conclusion: In conclusion results of this study suggest that photothermal ablation using gold-silicone nanoparticles and exposure to near infrared light (808 nm) provides an effective local therapy of low-grade mast cell tumors. Median progression free time and survival was not reached in our treatment group. Suggesting that long term tumor control is possible with PTA that potentially equals surgery when margins are narrow (<0.3cm) or incomplete. PTA appears to have better and more durable MCT responses than either radiation therapy and electrochemotherapy when used as sole therapies.
Clinical Analysis of Eleven Cases of Spontaneous Umbilical Cord Vascular Rupture During Pregnancy
Authors: Luo Jinying , Zhou Jinfu , Huang KeHua , Li LiYing , Yan JianYing 
Published: August 2021

Abstract
Background: Spontaneous umbilical cord vascular rupture is a rare but catastrophic event during pregnancy, and the perinatal mortality rate is extremely high. Live neonates may have severe asphyxia and require admission to the neonatal intensive care unit for many days. Methods: A retrospective review of the clinical data of eleven patients with spontaneous umbilical cord vascular rupture from 2012 to 2020, was undertaken at our hospital. Results: All patients were diagnosed by postpartum placental examination and pathological examination. The Obstetric Rapid Response Team performed emergency cesarean sections in fetal distress patients, and the time between detection of fetal heart abnormality and delivery was 5 to 13 minutes. Eight patients had bloodstained amniotic fluid and one had III° foul amniotic fluid. Six patients had the umbilical cord around their necks. Furthermore, pathological examination of postpartum placentas found four cases of intrauterine infection.Among the eight live neonates, one neonate died two days after birth due to severe complications and one had neonatal hyperbilirubinemia. No neurological sequelae, or other severe complications were found in the remaining seven neonates after three months of follow-up, and all of them had a positive prognosis.Conclusion: Spontaneous umbilical cord vascular rupture is a serious risk for perinatal birth life and obstetric complications. For this reason, obstetricians should be familiar with and pay attention to its risk factors.
The Long-Term And Short-Term Effects of Green Strategy On Corporate Performance: Evidence From Chinese Listed Companies
Authors: Yu Weihua , Jin Xin 
Published: August 2021

Abstract
While a growing body of literature has examined the link between green strategy and firm performance, little attention has been paid to distinguishing short-term from long-term and effects, and the underlying mechanisms through which green strategy takes effect are also rarely discussed. This paper leverages the context of implementing a green strategy among Chinese listed companies to examine how the green strategy impacts the company’s short-term and long-term financial performance. Drawing from the resource-based view (RBV), we argue that the implementation of the green strategy facilitates the company's long-term performance but inhibits short-term performance due to the mediating effects of firms’ debt ratio. The current research makes substantial contributions to the literature and provides important implications for policymakers and firm managers.
Study of how clinical and sociodemographic variables influence chemotherapy-induced cognitive deterioration in women with breast cancer
Authors: Martín Blanca Rodríguez , Rodríguez Eduardo José Fernández , Gomez Celia Sanchez , Hernandez Juan Jesús Cruz , Galve María Isabel Rihuete 
Published: August 2021

Abstract
Background: Of the many side effects suffered by cancer patients, those related to cognitive performance have become increasingly prominent in clinical practice. We know that chemotherapy generates a series of side effects, such as nausea and vomiting, alopecia, and so on, which can be counteracted by complementary medication. However, in the case of post-chemotherapy cognitive impairment, or chemo brain, these cannot be controlled with drug therapies. However, before any intervention can be considered, it is necessary to know exactly what cognitive impairment is being triggered. For this reason, we decided to study the cognitive status of breast cancer patients. Methods: analytical, prospective, three-measure longitudinal, intrasubject unifactorial, non-probabilistic and accidental assignment study. The sample came from the Medical Oncology Department at Hospital de Salamanca, in Spain. Cognitive function (Trail Making Test and Stroop Test) was established as the primary variable; the presence of sleep disorders (Insomnia Severity Index, ISI) and anaemia (haemoglobin levels in blood) were analysed as secondary variables, in addition to intervening variables (age, stage, type of carcinoma, radiotherapy, menopause, social support network, marital status, years of schooling and employment status). Results: We recruited 151 individuals according to the selection criteria. We can confirm that factors including anaemia, menopause, patient support network and marital status, years of schooling, and employment status did affect the cognitive performance of the patients in the study. In contrast, sleep disorders, age, radiotherapy treatment, stage of disease, and type of carcinoma did not affect the cognitive performance of the cancer patients. Conclusions: Chemotherapy does impact the cognitive performance of breast cancer patients.
The Evolution of COVID-19: A Minimal Invasive Autopsy Cohort Studying in Depth the Different COVID- 19 Disease Stages
Authors: D’Onofrio Valentino , Keulen Lotte , Vandendriessche Annelore , Dubois Jasperina , Cartuyvels Reinoud , Abeele Marie-Elena Vanden , Fraussen Judith , Vandormael Patrick , Somers Veerle , Achten Ruth , Dendooven Amélie , Driessen Ann , Augsburg Lukasz , Hellings Niels , Lammens Martin , Vanrusselt Jan , Cox Janneke 
Published: August 2021

Abstract
Background The WHO defines different COVID-19 disease stages, where pathophysiological mechanisms differ. Clinical, radiological, histological, microbiological, and immunological characteristics of different COVID-19 disease stages were evaluated. Methods Forty-four PCR-confirmed COVID-19 patients were included in a prospective minimal invasive autopsy cohort. Patients were classified according to WHO disease classification in mild-moderate (n=4), severe-critical (n=32) and post-acute disease (n=8) and clinical, radiological, histological, microbiological, and immunological data were compared. Results Classified according to Thoracic Society of America, patients with mild-moderate disease had no typical COVID-19 images on CT-Thorax versus 71.9% with typical images in severe-critical disease and 87.5% typical images in post-acute disease (p<.001). Diffuse alveolar damage was absent in mild-moderate disease but present in 93.8% and 87.5% of patients with severe-critical and post-acute COVID-19, respectively (p=.002). Other organs with histopathological changes were liver and heart. Interferon-g levels were significantly higher in patients with severe-critical COVID-19. Overall, 72% of patients had positive anti-SARS CoV-2 IgM and 51% positive IgG. Conclusion Significant differences in pathological and immunological characteristics between patients with mild-moderate disease compared to patients with severe-critical disease were found, whereas differences between patients with severe-critical disease and post-acute disease were limited. This emphasizes the need for tailored treatment of COVID-19 patients.
Association Between Placental Location and Neonatal Outcomes in Manual Fundal Pressure-Assisted Vaginal Deliveries: A Retrospective Cohort Study
Authors: Kamijo Kyosuke , Shigemi Daisuke , Kaszynski Richard H , Nakajima Mikio 
Published: August 2021

Abstract
Purpose: Manual fundal pressure (MFP) is globally used to assist vaginal deliveries during the second stage of labor; however, there is insufficient evidence on the risk factors in MFP-assisted vaginal deliveries for adverse neonatal outcomes. The aim of the present study was to investigate the association between placental location and neonatal outcomes in MFP-assisted vaginal deliveries.Methods: The present was a single-center observational study using a cohort of all MFP-assisted vaginal singleton deliveries from 2016 to 2020. Placental location was divided into two categories: posterior-lateral and anterior-fundal. The primary outcome was a neonatal adverse composite including umbilical artery blood pH <7.2, Apgar score <7 at 5 min, neonatal intensive care unit admission and neonatal resuscitation. We used logistic regression models to investigate the association between placental location and neonatal outcomes. Results: We extracted 522 MFP-assisted deliveries among 5053 vaginal deliveries. The proportion of posterior-lateral and anterior-fundal placentation was 239 (45.8%) and 283 (54.2%), respectively. The crude prevalence of neonatal composite outcome for posterior-lateral and anterior-fundal placentation was 69 (28.9%) and 112 (39.6%), respectively. The prevalence of neonatal composite outcome in the anterior-fundal group was significantly higher than that in the posterior-lateral group. Multivariable logistic regression analysis found that the prevalence of neonatal adverse outcome in the anterior-fundal group was significantly higher compared with the posterior-lateral group (adjusted odds ratio, 1.55; 95% confidence interval, 1.05–2.28).Conclusion: Anterior-fundal placentation was significantly associated with an increased risk of neonatal adverse outcomes compared to posterior-lateral placentation in MFP-assisted vaginal deliveries.
Impact of the first national COVID-19 lockdown on referral of women experiencing domestic violence and abuse in England and Wales
Authors: Panovska-Griffiths Jasmina , Szilassy Eszter , Johnson Medina , Dixon Sharon , Simoni Anna , Wileman Vari , Dowrick Anna , Emsley Elizabeth , Griffiths Chris , Barbosa Estela Capelas , Feder Gene 
Published: August 2021

Abstract
Background
The COVID-19 pandemic, with the related lockdown periods to curb transmission, has made it harder for survivors of domestic violence and abuse (DVA) to disclose abuse and access support services. Our study describes the impact of the first COVID-19 wave and the associated national lockdown in England and Wales on the referrals from general practice to the IRIS (Identification and Referral to Improve Safety) DVA programme. We compare this to the change in referrals in the same months in the previous year, during the school holidays in the three years preceding the pandemic and the period just after the first COVID-19 wave. School holiday periods were chosen as a comparator, since families, including the perpetrator, are together, affecting access to services.
Methods
We used anonymised data on daily referrals received by the IRIS DVA service in 33 areas from general practices over the period April 2017-September 2020. Interrupted-time series and non-linear regression were used to quantify the impact of the first national lockdown in March-June 2020 comparing analogous months the year before, and the impact of school holidays (01/04/2017-30/09/2020) on number of referrals, reporting Incidence Rate Ratio (IRR), 95% confidence intervals and p-values.
Results
The first national lockdown in 2020 lead to reduced number of referrals to DVA services (27%,95%CI=(21%,34%)) compared to the period before and after, and 19% fewer referrals compared to the same period in the year before. A reduction in the number of referrals was also evident during the school holidays with the highest reduction in referrals during the winter 2019 pre-pandemic school holiday (44%,95%CI=(32%,54%)) followed by the effect from the summer of 2020 school holidays (20%,95%CI=(10%,30%)). There was also a smaller reduction (13%-15%) in referrals during the longer summer holidays 2017–2019; and some reduction (5%-16%) during the shorter spring holidays 2017–2019.
Conclusions
We show that the COVID-19 lockdown in 2020 led to decline in referrals to DVA services. Our findings suggest an association between decline in referrals to DVA services for woman experiencing DVA and prolonged periods of systemic closure proxied here by both the first COVID-19 national lockdown or school holidays. This highlights the need for future planning to provide adequate access and support for people experiencing DVA during future national lockdowns and during the school holidays.