bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Eribulin on Angiogenesis and Endothelial Adhesion Molecule Expression.
Authors: Abbona Andrea , Paccagnella Matteo , Astigiano Simonetta , Martini Stefania , Denaro Nerina , Ruatta Fiorella , Barbieri Ottavia , Merlano Marco Carlo , Garrone Ornella 
Published: November 2021

Abstract
Tumor vasculature is an important component of the tumor microenvironment and deeply affects anticancer immune response. Eribulin is a non-taxane inhibitor of the mitotic spindle. However, off-target effects interfering with the tumor vasculature have been reported. The mechanisms responsible of this effect are still unclear.We designed an in vitro study to investigate the effect of eribulin, with or without TGF-β, on neo-angiogenesis, and on the expression of the adhesion molecules ICAM-1 and VCAM-1. We also investigated the effects of paclitaxel and vinorelbine in the same experimental conditions.Eribulin up-regulated the epithelial markers VE-cadherin and CD-31 in HUVEC and inhibited tube formation in HUVEC cultured in Matrigel. The drug effectively arrested tube formation even in presence of TGF-β and counteracted the TGF-β-induced change in cell shape from the endothelial cobblestone-like morphology to an elongated spindleshaped morphology.We also observed that eribulin was able to upregulate ICAM-1 and to counteract its downregulation induced by TGF-β.Eribulin therefore exerts different off-label effects: increases vascular remodeling, counteracts the endothelial tomesenchymal transition (EndMT) mediated by TGF-β and promotes tumor infiltration by immune cells by increasing expression of ICAM-1 and transcription of CD31 and VE-cadherin.Moreover, eribulin was able to inhibit vasculature remodeling and the induction of EndMT mediated by TGF-β better than vinorelbine and paclitaxel.The effects observed in this study might have important therapeutic consequence if the drug will be administered with immunotherapy.
Pay-it-forward to improve influenza vaccine uptake and public engagement among children and older adults in China: A three-arm quasi-experimental study
Authors: Wu Dan , Jin Chenqi , Bessame Khaoula , Tang Fanny , Ong Jason , Wang Zaisheng , Xie Yewei , Jit Mark , Larson Heidi , Chantler Tracey , Lin Leesa , Gong Wenfeng , Yang Fan , Jing Fengshi , Wei Shufang , Cheng Weibin , Zhou Yi , Ren Nina , Qiu Shuhao , Bao Jianmin , Wen Liufen , Yang Qinlu , Tian Junzhang , Tang Weiming , Tucker Joseph 
Published: November 2021

Abstract
China has low seasonal influenza vaccination rates among children and older adults. This quasi-experimental pragmatic trial examined the effectiveness of a pay-it-forward intervention on influenza vaccination compared to standard of care (user-paid vaccination) and free vaccination strategies among children and older people in China (ChiCTR2000040048). In pay-it-forward, people receive a free influenza vaccine from a local group and are offered an opportunity to donate financially to support vaccination among future individuals. The primary outcome was pre-specified as influenza vaccine uptake. Secondary outcomes included vaccine confidence and associated costs. Among 450 participants enrolled, 55/150 (36.7%) in the standard of care arm, 111/150 (74.0%) in the pay-it-forward arm, and 114/150 (76.0%) in the free vaccination arm received an influenza vaccine. The pay-it-forward arm had significantly higher vaccine confidence when compared to the standard of care arm. In the pay-it-forward arm, 107/111 (96.4%) of participants donated money for subsequent vaccinations and 19 of 60 invited (31.7%) created postcard messages.
Relational Capital And Strategic Orientations As Antecedents of Innovation: Evidence From Mexican SMEs
Authors: RAMIREZ-SOLIS EDGAR ROGELIO , Llonch Joan , Malpica-Romero Alberto 
Published: November 2021

Abstract
Despite the importance of strategic orientations and relational capital in businesses, little research has been carried out on the relationship of these factors with the innovation process. Nor has the behavior of strategic orientations been sufficiently studied if we measure them together. This paper examines the relationship between those factors with firm performance. We propose relational capital as a source of innovation for small- and medium-sized enterprises (SMEs) through strategic orientations. Therefore, this study contributes to advanced knowledge in the SMEs competitive research stream. A total of 360 respondents completed a survey conducted at four main cities in México. Using the structural equation modeling (SEM) technique, our results reveal a strong positive effect of relational capital over strategic orientations. Mixed findings of strategic orientations and innovation are presented. The findings offer managerial insights for managers to improve performance through innovation and strategic orientations using relational capital.
WITHDRAWN: Rare Metachronous Multiple Carcinoma of Ear, Nose and Throat: A Case Report: Metachronous Multiple Carcinoma of Bilateral Maxillary Sinus and Lung
Authors: Liu Yue , Liu Yan , Li Qiu Jin , Guo Xian Hai , Zhao Xue , Yu Dan 
Published: November 2021

Abstract
BackegroundTo report a rare case of metachronous multiple carcinoma of bilateral maxillary sinus and lung.MethodsThe clinical manifestations, pathological results, endoscopic findings and imaging features of the patient were collected and summarized.ResultsThe patient, male, 58 years old, came to our department in 2010 for "left exophthalmos and blood in snot". Combined with relevant examinations, it was diagnosed as malignant tumor of the left maxillary sinus. Postoperative radiotherapy and chemotherapy were performed. Ten years later, the patient developed right maxillary sinus cancer and left lung cancer. The postoperative pathological return of lung was lung adenocarcinoma,excluding the possibility of metastasis.Conclusions﻿For otorhinolaryngology,this case of isochronous multiple lung cancer in bilateral maxillary sinuses is very rare, which also suggests that we should closely follow up tumor patients in clinical treatment.In addition to the primary site, we should also strengthen the monitoring of radiotherapy operation area and easily metastatic organs (such as lung, bone, liver, etc.), strengthening the popularization of relevant knowledge and improve patients' awareness of disease prevention, changing the bad lifestyle, further reducing the incidence of multiple primary cancer or early detection of cancer and improving the quality of life of patients.
WITHDRAWN: Parametric Optimization of Friction Stir Welding Factors (FSWF) for Yellow Brass 405-20
Authors: Raza Syed Farhan , Khan Sarmad Ali , Habib Muhammad Salman , Ahmed Naveed , Ishfaq Kashif , Mehdi Ahmed 
Published: November 2021

Abstract

Friction stir welding (FSW) is a green, environmentally amicable, and solid-state joining technology. Industries are really interested in adopting FSW in its various applications e.g., automobile, aerospace, marine, construction, etc. FSW can successfully weld a wide range of materials (similar/dissimilar parent materials) including aluminum, copper, steel, different alloys from these materials, plastics, composites, and this material range is subjected to extension if FSW research efforts develop further in future. FSW of brass has already been accomplished by fewer researchers. In this research, yellow brass 405-20 is, therefore, welded with FSW that was never welded before. In this study, tool material utilized was M2 HSS that was also novel. Effect of two friction stir weld factors (FSWF), rotational speed (RS) and traverse speed (TS), was found on three output parameters i.e., weld temperature, weld strength and weld hardness. Weld temperature was found to be 63.72% of melting point of base metal. A significant improvement in friction stir weld strength (FSWS) was also measured that was found to be 82.78% of the base brass strength. Finally, weld hardness was measured which was found to be 87.80% of original brass hardness. Based on main effects of Anova Analysis, optimal FSW factors were found to be 1450 rpm and 60 mm/min resulting interestingly in maximum (max.)/optimal temperature, max./optimal weld strength, and minimum/optimal hardness. Rotational speed (RS) was found to be significant to affect the weld temperature only at the friction stir weld zone (FSWZ) with the highest percent contribution (PCR) of 65.69%. Transverse speed (TS) was found to be overall insignificant for affecting weld temperature, weld strength and hardness. However, PCR of transverse speed was found to be maximum for affecting weld strength as compared to its PCR towards both weld temperature and weld hardness. Error PCR was found to be the lowest for weld zone temperature, then for weld strength, and finally the highest for weld hardness. Interaction Plots (IPs) were also made for those FSWF which were found to be insignificant and to investigate any combined effect of FSWF on output parameters causing increased error PCR towards weld temperature, weld strength, and weld hardness.
Changes in thromboelastography to predict ecchymosis after knee arthroplasty: a promising guide for the use of anticoagulants: a case control study
Authors: Chen Yuelong , Qin Leilei , Wang Jiawei , Gong Xuan , Hu Ning 
Published: November 2021

Abstract
BackgroundEcchymosis is one of the worrisome complications after total knee arthroplasty (TKA) and interferes with functional rehabilitation. Current clinical guidelines do not provide individualized approaches for patients with ecchymoses. In this study, we used thromboelastography (TEG) to determine the coagulation state after TKA and to then explore markers that predict the occurrence of ecchymosis events after TKA.MethodsIn our cohort, patients were divided into ecchymosis (n=55) and nonecchymosis (n=137) groups according to whether ecchymosis events occurred after TKA. Rivaroxaban 10 mg/d was taken orally for thromboprophylaxis after surgery. All patients completed TEG testing. Correlation analysis was used to determine the risk factors for ecchymosis after TKA, and receiver operating characteristic (ROC) curves for variables with significant correlation were plotted.ResultsIn all, 55 of the 192 patients (28.65%) developed ecchymosis surrounding the surgical site. Multivariate analysis showed that hidden blood loss (OR = 1.003 and p =.005) and changes in the coagulation index (ΔCI) values (OR = 0.351 and p =.001) were risk factors for ecchymosis after TKA. Using the Youden index, 0.1805 was determined as the optimal threshold value of ΔCI for predicting the occurrence of ecchymosis, with a sensitivity of 74.55% and specificity of 72.99%.ConclusionsΔCI is a promising marker as an alarm for the occurrence of ecchymosis after TKA.Trial registrationChinese Clinical TrialRegistry, ChiCTR, NO. ChiCTR1800017245. Registered 19 July 2018 - Prospective registered, http://www.chictr.org.cn
Using Machine Learning To Improve the Accuracy of Genomic Prediction on Reproduction Traits in Pigs
Authors: Wang Xue , Shi Shaolei , Wang Guijiang , Luo Wenxue , Wei Xia , Qiu Ao , Luo Fei , Ding Xiangdong 
Published: November 2021

Abstract
Background

Recently, machine learning (ML) is becoming attractive in genomic prediction, while its superiority in genomic prediction and the choosing of optimal ML methods are needed investigation.
Results

In this study, 2566 Chinese Yorkshire pigs with reproduction traits records were used, they were genotyped with GenoBaits Porcine SNP 50K and PorcineSNP50 panel. Four ML methods, including support vector regression (SVR), kernel ridge regression (KRR), random forest (RF) and Adaboost.R2 were implemented. Through 20 replicates of five-fold cross-validation, the genomic prediction abilities of ML methods were explored. Compared with genomic BLUP(GBLUP), single-step GBLUP (ssGBLUP) and Bayesian method BayesHE, our results indicated that ML methods significantly outperformed. The prediction accuracy of ML methods was improved by 19.3%, 15.0% and 20.8% on average over GBLUP, ssGBLUP and BayesHE, ranging from 8.9–24.0%, 7.6–17.5% and 11.1–24.6%, respectively. In addition, ML methods yielded smaller mean squared error (MSE) and mean absolute error (MAE) in all scenarios. ssGBLUP yielded improvement of 3.7% on average compared to GBLUP, and the performance of BayesHE was close to GBLUP. Among four ML methods, SVR and KRR had the most robust prediction abilities, which yielded higher accuracies, lower bias, lower MSE and MAE, and comparable computing efficiency as GBLUP. RF demonstrated the lowest prediction ability and computational efficiency among ML methods.
Conclusion

Our findings demonstrated that ML methods are more efficient than traditional genomic selection methods, and it could be new options for genomic prediction.
Risk Assessment For Readmission For Phototherapy in Neonates With ABO Hemolytic Disease
Authors: Xu Chuncai , Bao Yingying , He Yuanyuan , Zhao Jingxin , Ji Fengjuan , Wu Mingyuan , Zhu Jiajun 
Published: November 2021

Abstract
Background: ABO hemolytic disease of the newborn (ABO HDN) is a main risk factor for neonatal hyperbilirubinemia, which is one of the most common causes for readmission in neonates after discharge. Our objective is to assess the risk factors for readmission in neonates with ABO hemolytic disease for phototherapy.Methords: 291 neonates at gestational age ≥ 35 weeks were enrolled with the diagnosis of ABO hemolytic disease by collecting their clinical and laboratory data retrospectively. All these infants were born in Women’s Hospital School of Medicine Zhejiang University between 2018 and 2019. . Among these neonates, 36 cases were readmitted due to hyperbilirubinemia, which is defined as the study group, while the other 255 cases as the control group.Results: The study and control groups were similar on maternal and infants basic parameters (P> 0.05), as well as the complications of both infants and mothers (P> 0.05). However, we found significant differences in the concentration of initial total serum bilirubin, the onset age for phototherapy, the positive direct antiglobulin test (DAT) between two groups (P <0.05). Logistic regression analysis suggested that the age for onset phototherapy and the initial level of total serum bilirubinwere both independent risk factors for readmission in neonates with ABO hemolytic disease.Conclusions: For neonates with hyperbilirubinemia due to ABO HDN, positive direct antiglobulin test (DAT), small age for phototherapy and high initial level of bilirubin can increase the risk of readmission for phototherapy.
Ivermectin for the prevention of COVID-19: addressing potential bias and medical fraud
Authors: Hill Andrew , Mirchandani Manya , Ellis Leah , Pilkington Victoria 
Published: November 2021

Abstract

Background
Ivermectin is an antiparasitic drug being investigated in clinical trials for the prevention of COVID-19. However, there are concerns about the quality of some of these trials.
Objectives
To conduct a meta-analysis with randomised controlled trials of ivermectin for the prevention of COVID-19, while controlling for the quality of data.
Methods
We conducted a sub-group analysis based on the quality of randomised controlled trials evaluating ivermectin for the prevention of COVID-19. Quality was assessed using the Cochrane Risk of Bias measures (RoB 2) and additional checks on raw data, where possible.
Results
Four studies were included in the meta-analysis. One was rated as being potentially fraudulent, two as having a high risk of bias and one as having some concerns for bias. Ivermectin did not have a significant effect on preventing RT-PCR confirmed COVID-19 infection. Ivermectin had a significant effect on preventing symptomatic COVID-19 infection in one trial with some concerns of bias, but this result was based on post-hoc analysis of a multi-arm study.
Conclusions
This meta-analysis demonstrates that the currently available randomised trials evaluating ivermectin for the prevention of COVID-19 are insufficient and of poor quality.
Development of The Use of Primary Health Care Emergency Departments After Interventions Aimed At Decreasing Overcrowding: A Longitudinal Follow-up Study
Authors: Liedes-Kauppila Marja , Heikkinen Anna M. , Rahkonen Ossi , Lehto Mika , Mustonen Katri , Raina Marko , Kauppila Timo 
Published: November 2021

Abstract
Background: This study, conducted in a Finnish city, examined whether decreasing emergency department (ED) services in an overcrowded primary care ED and corresponding direction to office-hours primary care would modify service usage for specific gender, age or diagnosis groups. Methods: This was an observational retrospective study carried out by gradually decreasing ED services in primary care. The interventions aimed at decreasing use of EDs were a) application of ABCDE-triage combined with public guidance on the proper use of EDs, b) closure of a minor supplementary ED, and finally, c) application of “reverse triage” with enhanced direction of the public to office-hours services and away from the remaining ED The annual number of visits to office-hours primary care GPs in different gender, age and diagnosis groups (International Classification of Diseases (ICD-10) were recorded during a 13-year follow-up period. Results: The total number of monthly visits to EDs decreased slowly over the whole study period. This decrease was similar in women and men. The decrease was stronger in the youngest age groups (0-19 years). GPs treated decreasing proportions of ICD-10 groups. Recorded infectious diseases (Groups A and J, and especially diagnoses related to infections of respiratory airways) tended to decrease. However, visits due to injuries and symptomatic diagnoses increased. Conclusion: Decreasing services in a primary health care ED with the described interventions seemed to reduce the use of services by young people. The three interventions mentioned above had the effect of making the primary care ED under study appear to function more like a standard ED driven by specialized health care.
Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA
Authors: Gao Peng , Liu Yanqing , Xiao Wei , Xia Fei , Chen Jiayun , Gu Liwei , Yang Fan , Zheng Liuhai , Zhang Junzhe , Zhang Qian , Li Zhijie , Meng Yuqing , Zhu Yongping , Xu Chengchao , Dai Lingyun , Wang Jigang 
Published: November 2021

Abstract
Background

Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in developing countries. In the history of anti-malaria campaign, chloroquine (CQ) has played an indispensable role, however, its mechanism of action (MoA) is not fully understood.
Methods

We used the approach of photo-affinity labeling (PAL) in the design of a chloroquine probe and developed a combined deconvolution strategy – activity-based protein profiling (ABPP) and mass spectrometry-coupled cellular thermal shift assay (MS-CESTA) – that identified the protein targets of chloroquine in an unbiased manner in this study.
Results

We developed a novel photo-affinity chloroquine analog probe (CQP), which retains the antimalarial activity in the nanomole range, and identified a total of 40 proteins that specifically interacted and photo-crosslinked with CQP, which was inhibited in the presence of excess CQ. Using MS-CETSA, we identified 83 candidate interacting proteins out of a total of 3375 measured parasite proteins. Together, we identified 8 proteins as the most potential hits which were commonly identified by both methods.
Conclusions

We found that CQ could disrupt glycolysis and energy metabolism of malarial parasites through direct binding with some of the key enzymes, a new mechanism that is different from its known inhibitory effect of hemozoin formation. This is the first report of identifying chloroquine antimalarial targets by a parallel usage of labeled (ABPP) and label-free (MS-CETSA) methods.
Numerical analysis of NOX formation in CO2 diluted biogas premixed combustion
Authors: Susilo Sugeng Hadi , Wicaksono Hangga 
Published: November 2021

A further investigation of premixed biogas combustion towards the NOx formation is presented in this study. The purpose of the simulation is to determine the addition of CO2 in biogas fuel to the combustion behavior of premixed biogas on NOx formation, and to determine the occurrence of NOx in the pre-mixed biogas combustion. In this study, the Counterflow Premixed Flame class is used where this class is based on the One Dim class which is the basis for simulations with a 1-dimensional domain. The Counterflow Premixed Flame class uses an axisymmetric stagnation flow domain which has been written based on the equations. Cantera uses Newton's method to solve them. Completion is carried out in two stages. The first stage is to solve the solution using the equilibrium at each z coordinate point that has been determined. Many estimation starting points are determined from the start of the program. The second stage is the recalculation process at each point and then subdivided to get a smoother solution. The premixed excess CO2 biogas fuel and air combustion analyzed using a 1-dimensional numerical study. The diluted CO2 mass fraction ranged between 0–40 %. The CH4/CO2/air volume flow rate was maintained in ±L/min. The analysis implements the 1-D Counter Flow approach. Two counterflow nozzles were 20mm in diameter and the flame stagnation point at 10 mm. The results show that NOx mass fraction formed only on a fuel-lean mixture of CH4/CO2/air and its values decreased along with CO2 added. The addition of CO2 could reduce the NO species mass fraction down to 18 %, and NO2 reduction down to 7 %. This is mainly caused by a decreasing heat release rate of NO+N↔N2+O, N+O2↔NO+O, N+OH↔NO+H, and N+CO2↔NO+CO reactions. The N+CO2↔NO+CO reaction increased as CO2 was added but its values were not as much as the decline of three other reactions
Study of fluid layer gravity motion over vertical surface
Authors: Sarukhanyan Arestak , Sarkisyan Norik , Tokmajyan Vache , Vartanyan Arevshad 
Published: November 2021

This paper presents the results of studying the motion of a liquid layer along the walls of a vertically installed pipe under the action of gravity. Two-dimensional boundary layer is formed by the fluid motion relative to the hard wall on surfaces of structures (pipes, turbines, heat-and-mass transfer equipment, aircrafts, ships, etc.), which are of positive interest in engineering practice. Further upgrading of the above-mentioned structures is possible only by increasing accuracy of momentum in the boundary layer, heat and mass transfer rates calculation. It is confirmed that in the boundary layer transfer phenomena intensity (perpendicular to the wall) is due to the fluid particles velocity distribution regularities in the cross-section of the layer. Fluid velocity distribution regularities in turn are conditioned by Reynolds number according to current notions. The principal method of quantitative analysis of turbulent flow in a boundary layer suggested by Reynolds continues to be the velocity and pressure fluctuations averaging method for some timespan. The suggested model of fluid movement enables to prognosticate conditions under which in cross-sections of the boundary layer reshaping of velocity profile takes place, to carry out analytic calculation of such hydrodynamic characteristics as mean velocity of motion, layer thickness and shearing stresses acting on the wall. The difference between the suggested methods developed for calculation of flow parameters from the well-known ones is in that that calculations are made based on an integrated approach regardless of such conceptual definitions as laminar and turbulent regimes widely used in modern hydrodynamics. Obtained results and design formulas known in the literature have been compared. It has been found that the thickness of the sliding layer, determine by the proposed calculation formula, 1.17 times smaller than that determined by the currently used formula