bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penerapan Terapi Aktivitas Kelompok (TAK) Dan Senam Lansia Sebagai Upaya Pengendalian Demensia Pada Lansia
Authors: Sigalingging Ganda , Nasution Zulkarnain , Pakpahan Hetti Marlina , Tafonao Nasilia 
Published: August 2021

ABSTRAK Ancaman triple burden merupakan tantangan yang harus dihadapi di Indonesia, diantaranya jumlah lansia yang terus meningkat. Seiring pertambahan usia, berpotensi menimbulkan masalah kesehatan fisik dan psikososial antara lain depresi, harga diri rendah, bahkan bunuh diri, jika tidak ditangani dengan serius. Oleh karena itu, diperlukan upaya mempertahankan kesehatan lansia pada taraf kesehatan optimal. Tujuan untuk meningkatkan kemampuan lansia berinteraksi dalam rangka pencapaian penyesuaian psikologi, perilaku dan pencapaian adaptasi optimal. Metode kegiatan melakukan senam sehat dan terapi aktivitas kelompok (TAK). Hasil kegiatan menunjukkan, secara keseluruhan lansia terlihat ceriah dan bahagia. Disimpulkan kegiatan ini mampu meningkatkan semangat dan menciptakan kebersamaan sesama lansia selama berada di rumah Jompo. Kepada Yayasan panti jompo untuk memfasilitasi kegiatan sesuai kebutuhan lansia yaitu melakukan terapi aktivitas kelompok (TAK) dengan senam sehat secara berkesinambungan untuk tercipta perasaan yang riang gembira sehingga kualitas hidup lansia tetap sehat, mandiri, berguna, dan produktif. Kata kunci : Terapi aktivitas kelompok, senam sehat, demensia, lansia. ABSTRACT The triple threat is a challenge that must be faced in Indonesia. More and more the number of elderly continues to increase. As you age, changes occur due to the aging process that causes physical and psychosocial problems. one of the psychosocial problems in the elderly is low self-esteem. If that doesn't work, the elderly will repair, attract, challenge, and even escape. Therefore, it is necessary to maintain the health of the elderly at an optimal level of health. The goal is to increase the ability of the elderly in the contexts of psychological loss, behavior, and optimal adaptation. Activity methods of doing healthy gymnastics and group activity therapy. The results of the activity showed that overall the elderly looked bright and happy. This activity can increase enthusiasm and create togetherness among the elderly in a nursing home. Keywords: Group activity therapy, healthy gymnastics, dementia, elderly.
Pengabdian Masyarakat di Wilayah Kerja puskesmas Pancu Batu Kabupaten Deliserdang
Authors: Sigalingging Vina Yolanda Sari , Simanullang Murni Sari Dewi , Simorangkir Lindawati , Barus Mardiati , Pakpahan Rotua Elvina , Tampubolon Lindawati F , Derang Imelda 
Published: August 2021

ABSTRAK Untuk mencapai kesehatan yang panjang harus dimulai sejak dini. Pada usia dini, balita sangatlah berperan penting sebagai permulaan kehidupan yang akan datang. Tindakan kesehatan yang dapat dilakukan diawal kehidupan manusia adalah dengan adanya imunisasi. Imunisasi yang di berikan haruslah lengkap hingga batas usia dengan berbagai macam imunisasi yang akan diterima. Tujuan dari pengabdian masyarakat ini adalah untuk meningkatkan kesehatan balita sejak dini. Sasaran kegiatan ini adalah bayi dibawah umur 5 tahun yang akan menerima imunisasi. Hasil dari kegiatan ini adalah balita yang dating mendapatkan imunisasi sesuai dengan umurnya. Diharapkan dengan dilaksanakannya pengabdian masyarakat ini, para ibu dapat rajin untuk membawa balita mereka untuk di bawa keposyandu secara rutin dan balita mendapatkan imunisasi lengkap guna memberikan kesehatan yang baik di masa yang akan dating dan mengurangi resiko sakit, cacat dan kematian pada balita. Kata Kunci :Posyandu, Balita ABSTRACT To achieve long health must start early. At an early age, toddlers are very important as the beginning of life to come. Health action that can be done early in human life is immunization. The immunization given must be complete up to the age limit with a variety of immunizations to be received. The purpose of this community service is to improve the health of toddlers from an early age. The target of this activity is infants under 5 years of age who will receive immunizations. The result of this activity is toddlers who come to receive immunizations according to their age. It is hoped that with the implementation of this community service, mothers can be diligent in bringing their toddlers to the Integrated Healthcare Center, regularly and toddlers get complete immunizations to provide good health in the future and reduce the risk of illness, disability and death in toddlers. Keywords: Integrated Healthcare Center, Toddler
Pemberdayaan Keluarga Melalui Pendampingan Budidaya “Empon-Empon” Serta Produksi Dan Branding Karak Non “Bleng”
Authors: Pangestu Lila , Nur Annisa Syarah Ayu 
Published: August 2021

Pandemi Corona Virus 19 berdampak terhadap keseluruhan aspek kehidupan , khususnya ketahanan ekonomi keluarga dengan ditandai adanya menurunnya produksi, distribusi, pendapatan dari home industry Tujuan kegiatan ini adalah memberdayakan keluarga melalui budidaya empon- empon serta membranding karak non “bleng berbasis kearifan lokal di Dusun Nglaroh, Nangsri, Kebakkramat, Karanganyar. Metode pendekatan pada kegiatan ini adalah rural development and empowerment melalui penyampaian materi, diskusi, latihan praktik (drill practice) serta pendampingan. Sasaran kegiatan ini adalah kelompok produktif ekonomi yang terdiri dari 10 home industri dan kelompok masyarakat non produktif ekonomi yang berjumlah 30 keluarga. Indikator kegiatan ini adalkah peningkatan pengetahuan dan ketrampilan dalam budidaya empon – empon dan pengetahuan dan keteampilan dalam pengelolaan kerak non bleng sebagai produk unggulan serta partisipasi peserta dalam kegiatan. Instrument yang dipakai adalah ceklist pre dan post. Adapun hasil kegiatan ini adalah adanya peningkatan pengatahuan, ketrampilan serta partisipasi masyarakat terhadap aspek kegiatan ini sebesar 90%. Ketahanan ekonomi keluarga dapat diperbaiki melalui pemberdayaan kelompok degan budidaya empon- embpon dan branding kerak belng pada masyarakat ekonomi produktif dan non preoduktif di desa Ngangsi Kebak kramat Karanganyar Jawa Tengah
Cardiotoxicidad en una Cohorte de pacientes con Diagnóstico de Cáncer de Mama que Recibieron Quimioterapia con Antraciclinas. Seguimiento a 12 años
Authors: Santacruz Maridueña Mayra Patricia , García Matamoros EDITOR: Dra. Katherine 
Published: August 2021

Introducción: Los esquemas de quimioterapia en el tratamiento de cáncer de mama incluyen Antraciclinas con una efectividad de respuesta alta, sin embargo en algunos casos el potencial efecto terapéutico se ve limitado por la Cardiomiopatía Inducida por Antraciclinas (CIPA). El objetivo del estudio fue establecer la prevalencia longitudinal de esta entidad.
Métodos: Este estudio observacional, longitudinal fue realizado en el Instituto Oncológico Nacional “Dr. Juan Tanca Marengo” -SOLCA-Guayaquil. El período de exposición fue abril a diciembre del 2008. El período de observación terminó el 30 de junio del 2020. Incluyó mujeres >18 años con cáncer de mama, en tratamiento con antraciclinas, clasificadas por riesgo Cardiovascular de Framingham en Riesgo Bajo (A), riesgo moderado (B) y riesgo alto (C). Se midió las Alteraciones electrocardiográficas (AEKG) basales, a las 6 horas y a las 24 horas y desarrollo de CIPA en seguimiento a 12 años. La muestra fue no probabilística tipo censo. Se utiliza estadística descriptiva con Intervalo de confianza para proporciones.
Resultados: Ingresaron al estudio 50 casos son AEKG. El desarrollo de AEKG a 6 horas en 18/50 casos (36% IC95% 34.1-37.9%), estas AEKG persistieron hasta las 24 horas. Las AEKG se presentaron en un 18.52% en mujeres con Riesgo A, 52.38% en Riesgo B y 100% en Riesgo C. El desarrollo de CIPA a 12 años fue de 3.57% (2.27-4.87%) en CIPA-Subaguda y de 7.14% (5.34-8.95% en CIPA crónica. CIPA Subaguda+ crónica 10.71% (8.55-12.88%).
Conclusiones: En este estudio se concluye que los eventos de cardiotoxicidad aguda fueron detectados por cambios electrocardiográficos y que en el seguimiento a largo plazo fueron evidentes en un porcentaje un poco mayor a la reportada en la literatura internacional.
GAMBARAN PENGETAHUAN DAN SIKAP PERAWAT RUANG OK DALAM PEMBERIAN INISIASI MENYUSU DINI (IMD) DI RSUD Dr. HADRIANUS SINAGA PANGURURAN KABUPATEN SAMOSIR TAHUN 2019
Authors: Marpaung Ricard Fredrik , Derlina Rostio 
Published: August 2021

Tujuan penelitian ini adalah mengetahui gambaran pengetahuan dan sikap perawat ruang OK dalam pemberian inisias menyusui dini (IMD) di RSUD Dr. Hadrianus Sinaga Pangururan Kabupaten Samosir Tahun 2017. Jenis penelitian ini adalah cross-sectional. Populasi dalam penelitian ini adalah seluruh perawat ruang OK RSUD Dr. Hadrianus Sinaga Pangururan Kabupaten Samosir yaitu sebanyak 10 orang. Data dikumpulkan melalui pengisian kuesioner dan dianalisis secara deskriptif berupa frekuensi dan persentase. Didapatkan bahwa: 1) mayoritas mempunyai pengetahuan cukup yaitu sebanyak 4 orang (40%) sedangkan minoritas mempunyai pengetahuan baik yaitu sebanyak 3 orang (30%) dan pengetahuan kurang yaitu sebanyak 3 orang (30%), 2) mayoritas mempunyai sikap setuju yaitu sebanyak 7 orang (70%) sedangkan minoritas sikap tidak setuju yaitu sebanyak 3 orang (30%).
Kata kunci: inisiasi menyusu dini (IMD); pengetahuan; sikap
Chryseobacterium aquifrigidense FANN1 Produced Detergent-Stable Metallokeratinase and Amino Acids Through the Abasement of Chicken Feathers
Authors: Bokveld Amahle , Nnolim Nonso E. , Nwodo Uchechukwu U. 
Published: August 2021

Microbial keratinases’ versatility in the beneficiation of keratinous waste biomass into high-value products prompts their application in diverse spheres hence, advancing green technology and the bioeconomy. Consequently, a feather-degrading Chryseobacterium aquifrigidense FANN1 (NCBI: MW169027) was used to produce keratinase, and its biochemical properties were determined. The optimization of physicochemical parameters and analysis of the free amino acid constituents of the feather hydrolysate were also carried out. FANN1 showed a maximum keratinase yield of 1,664.55 ± 42.43 U/mL after 72 h, at optimal process conditions that included initial medium pH, incubation temperature, inoculum size, and chicken feather concentration of 8, 30°C, 4% (v/v), and 15 (g/L), respectively. Analysis of degradation product showed 50.32% and 23.25% as the protein value and total free amino acids, respectively, with a relatively high abundance of arginine (2.25%) and serine (2.03%). FANN1 keratinase was optimally active at pH 8.0 and relatively moderate to high temperature (40–50°C). EDTA and 1,10-phenanthroline inhibited the keratinase activity, and that suggests a metallo-keratinase. The enzyme showed remarkable stability in the presence of chemical agents, with residual activity 141 ± 10.38%, 98 ± 0.43%, 111 ± 1.73%, 124 ± 0.87%, 104 ± 3.89%, 107 ± 7.79%, and 112 ± 0.86% against DTT, H2O2, DMSO, acetonitrile, triton X-100, tween-80, and SDS, respectively. The residual activity of FANN1 keratinase was enhanced by Sunlight (129%), Ariel (116%), MAQ (151%), and Surf (143%) compared to the control after 60 min preincubation. Likewise, the enzyme was remarkably stable in the presence Fe3+ (120 ± 5.06%), Ca2+ (100 ± 10.33%), Na+ (122 ± 2.95%), Al3+ (106 ± 10.33%); while Co2+ (68 ± 8.22%) and Fe2+ (51 ± 8.43%) elicited the most repressive effect on keratinase activity. The findings suggest that C. aquifrigidense FANN1 is a potential candidate for keratinous wastes bio-recycling, and the associated keratinase has a good prospect for application in detergent formulation.
Nomogram Model to Predict the Probability of Ovarian Hyperstimulation Syndrome in the Treatment of Patients With Polycystic Ovary Syndrome
Authors: Li Fei , Chen Ying , Niu Aiqin , He Yajing , Yan Ying 
Published: August 2021

ObjectiveThe objective of this study was to explore the risk factors of ovarian hyperstimulation syndrome (OHSS) in patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and to establish a nomogram model evaluate the probability of OHSS in PCOS patients.MethodsWe retrospectively analyzed clinical data from 4,351 patients with PCOS receiving IVF/ICSI in our reproductive medical center. The clinical cases were randomly divided into a modeling group (3,231 cases) and a verification group (1,120 cases) according to a ratio of about 3:1. The independent risk factors correlation with the occurrence of OHSS was identified by logistic regression analysis. Based on the selected independent risk factors and correlated regression coefficients, we established a nomogram model to predict the probability of OHSS in PCOS patients, and the predictive accuracy of the model was measured using the area under the receiver operating curve (AUC).ResultsUnivariate and multivariate logistic regression analyses showed that FSH (OR, 0.901; 95% CI, 0.847–0.958; P&lt;0.001), AMH (OR, 1.259; 95% CI, 1.206–1.315; P&lt;0.001), E2 value on the day of hCG injection (OR, 1.122; 95% CI, 1.021–1.253; P&lt;0.001), total dosage of Gn used (OR, 1.010; 95% CI, 1.002–1.016; P=0.041), and follicle number on the day of hCG injection (OR, 0.134; 95% CI, 1.020–1.261; P=0.020) are the independent risk factors for OHSS in PCOS patients. The AUC of the modeling group is 0.827 (95% CI, 0.795–0.859), and the AUC of the verification group is 0.757 (95% CI, 0.733–0.782).ConclusionThe newly established nomogram model has proven to be a novel tool that can effectively, easily, and intuitively predict the probability of OHSS in the patients with PCOS, by which the clinician can set up a better clinical management strategies for conducting a precise personal therapy.
Optimal Combinations of AT(N) Biomarkers to Determine Longitudinal Cognition in the Alzheimer's Disease
Authors: Lin Rong-Rong , Xue Yan-Yan , Li Xiao-Yan , Chen Yi-He , Tao Qing-Qing , Wu Zhi-Ying 
Published: August 2021

Background: National Institute on Aging—Alzheimer's Association (NIA-AA) proposed the AT(N) system based on β-amyloid deposition, pathologic tau, and neurodegeneration, which considered the definition of Alzheimer's disease (AD) as a biological construct. However, the associations between different AT(N) combinations and cognitive progression have been poorly explored systematically. The aim of this study is to compare different AT(N) combinations using recognized biomarkers within the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.Methods: A total of 341 participants were classified into cognitively unimpaired (CU; n = 200) and cognitively impaired (CI; n = 141) groups according to the clinical manifestations and neuropsychological tests. Cerebrospinal fluid (CSF) Aβ42 and amyloid-PET ([18F]flutemetamol) were used as biomarkers for A; CSF phosphorylated tau (p-tau) and tau-PET ([18F]flortaucipir) were used as biomarkers for T; CSF total tau (t-tau), hippocampal volume, temporal cortical thickness, [18F]fluorodeoxyglucose (FDG) PET, and plasma neurofilament light (NfL) were used as biomarkers for (N). Binary biomarkers were obtained from the Youden index and publicly available cutoffs. Prevalence of AT(N) categories was compared between different biomarkers within the group using related independent sample non-parametric test. The relationship between AT(N) combinations and 12-year longitudinal cognition was assessed using linear mixed-effects modeling.Results: Among the CU participants, A–T–(N)– was most common. More T+ were detected using p-tau than tau PET (p &lt; 0.05), and more (N)+ were observed using fluid biomarkers (p &lt; 0.001). A+T+(N)+ was more common in the CI group. Tau PET combined with cortical thickness best predicted cognitive changes in the CI group and MRI predicted changes in the CU group.Conclusions: These findings suggest that optimal AT(N) combinations to determine longitudinal cognition differ by cognitive status. Different biomarkers within a specific component for defining AT(N) cannot be used identically. Furthermore, different strategies for discontinuous biomarkers will be an important area for future studies.
Tumor Blood Flow Is a Predictor of Radiotherapy Response in Patients With Nasopharyngeal Carcinoma
Authors: Cao Xiujuan , Song Jian , Xu Juan , Gong Guanzhong , Yang Xinhua , Su Ya , Wang Lizhen , Bai Xiaodong , Hu Man , Yin Yong 
Published: August 2021

PurposeThe aim of this study was to evaluate tumor blood flow (TBF) as a predictor of radiotherapy response for nasopharyngeal carcinoma (NPC).Materials and MethodA total of 134 patients were divided into two groups, the complete response (CR) group and the partial response (PR) group based on RECIST 1.1 recommendations. The statistical difference was evaluated for pre- and mid- or post-treatment TBF and changes of TBF for tumors and metastatic lymph nodes between CR and PR, respectively. The receiver operation characteristic (ROC) curve was utilized to evaluate the accuracy of TBF in predicting the response of radiation therapy. The association between TBF and SUVmax was also investigated.ResultsThe reduction of TBF in CR was significantly lower than that in PR for primary tumors (P &lt;0.001) and metastatic lymph nodes (P &lt;0.001). The multivariate logistic regression analysis indicated that the reduction of TBF is an independent predictor of the response of radiation therapy for primary tumors (P &lt;0.001) and metastatic lymph nodes (P &lt;0.001). The accuracy of TBF reduction in predicting the response of radiation therapy was 0.817 in primary tumors and 0.924 in metastatic lymph nodes, respectively. No significant correlation was observed between the TBF values and SUVmax of primary tumors (r = -0.008, P = 0.954) and metastasis lymph nodes (r = -0.061, P = 0.652).ConclusionThis study suggests that the reduction of TBF is a promising parameter for evaluating the response of radiation therapy.
Sex-Specific Effects of Respiratory Muscle Endurance Training on Cycling Time Trial Performance in Normoxia and Hypoxia
Authors: Chambault Julie , Grand Grégorine , Kayser Bengt 
Published: August 2021

Objectives: We tested the hypotheses that respiratory muscle endurance training (RMET) improves endurance cycling performance differently in women and men and more so in hypoxia than in normoxia.Design: A prospective pre–post cross-over study with two testing conditions.Methods: Healthy and active women (seven, 24 ± 4 years, mean ± standard deviation [SD]) and men (seven, 27 ± 5 years) performed incremental cycling to determine maximum oxygen consumption (VO2peak) and power output (Wpeak) and on different days two 10-km cycling time trials (TTs) in normoxia and normobaric hypoxia (FiO2, 0.135, ~3,500 m equivalent), in a balanced randomized order. Next they performed supervised RMET in normoxia (4 weeks, 5 days/week, 30 min/day eucapnic hyperpnea at ~60% predicted maximum voluntary ventilation) followed by identical post-tests. During TTs, heart rate, ear oximetry reading, and Wpeak were recorded.Results: The VO2peak and Wpeak values were unchanged after RMET. The TT was improved by 7 ± 6% (p &lt; 0.001) in normoxia and 16 ± 6% (p &lt; 0.001) in hypoxia. The difference between normoxic and hypoxic TT was smaller after RMET as compared with that before RMET (14% vs. 21%, respectively, p &lt; 0.001). All effects were greater in women (p &lt; 0.001). The RMET did not change the heart rate or ear oximetry reading during TTs.Conclusion: We found a greater effect of RMET on cycling TT performance in women than in men, an effect more pronounced in hypoxia. These findings are congruent with the contention of a more pronounced performance-limiting role of the respiratory system during endurance exercise in hypoxia compared with normoxia and more so in women whose respiratory system is undersized compared with that of men.
Association of Different Forms of Child Maltreatment With Peer Victimization in Mexican Children and Adolescents
Authors: Martín-Babarro Javier , Toldos M. Paz , Paredes-Becerra Lorena , Abregu-Crespo Renzo , Fernández-Sánchez Juan , Díaz-Caneja Covadonga M. 
Published: August 2021

Objective: To examine the relationship between exposure to multiple forms of child abuse and neglect within the family context and peer victimization at school, accounting for the moderator effect of sex and educational level.Methods: Two thousand four hundred fifteen children and adolescents, aged 9 to 15 years, attending public schools in Mexico completed the Childhood Trauma Questionnaire-Short Form and a modified version of the Olweus' Bully/Victim Questionnaire. We used linear regression models to assess the association of five different forms of child abuse (emotional, physical, and sexual abuse, and emotional and physical negligence) with three forms of peer victimization (direct, indirect, and cyberbullying).Results: Direct forms of child abuse within the family (i.e., emotional, physical, and sexual abuse), but not neglect, were significantly and positively associated with a risk for peer victimization. In the fully adjusted models, emotional abuse was significantly associated with the three types of peer victimization: [indirect b = 0.48, t = 6.75, p &lt; 0.001, direct (b = 0.47, t = 4.89, p &lt; 0.001), and cyberbullying (b = 0.85, t = 5.45, p &lt; 0. 001)]; while physical abuse was positive and significantly associated with direct victimization (b = 0.29, t = 3.28, p &lt; 0.001). Boys suffering from sexual abuse within the family context showed higher levels of all subtypes of peer victimization. Students attending secondary school who suffered from sexual abuse showed higher levels of indirect victimization than did students attending primary schools.Conclusion: Child abuse within the family context seems to be associated with the risk of peer victimization. Preventive strategies to address bullying and promote resilience should take family factors into account. Interventions for high-risk families might be useful to prevent child multi-victimization.
Neural Networks Trained via Reinforcement Learning Stabilize Walking of a Three-Dimensional Biped Model With Exoskeleton Applications
Authors: Liu Chujun , Audu Musa L. , Triolo Ronald J. , Quinn Roger D. 
Published: August 2021

Our group is developing a cyber-physical walking system (CPWS) for people paralyzed by spinal cord injuries (SCI). The current CPWS consists of a functional neuromuscular stimulation (FNS) system and a powered lower-limb exoskeleton for walking with leg movements in the sagittal plane. We are developing neural control systems that learn to assist the user of this CPWS to walk with stability. In a previous publication (Liu et al., Biomimetics, 2019, 4, 28), we showed a neural controller that stabilized a simulated biped in the sagittal plane. We are considering adding degrees of freedom to the CPWS to allow more natural walking movements and improved stability. Thus, in this paper, we present a new neural network enhanced control system that stabilizes a three-dimensional simulated biped model of a human wearing an exoskeleton. Results show that it stabilizes human/exoskeleton models and is robust to impact disturbances. The simulated biped walks at a steady pace in a range of typical human ambulatory speeds from 0.7 to 1.3 m/s, follows waypoints at a precision of 0.3 m, remains stable, and continues walking forward despite impact disturbances and adapts its speed to compensate for persistent external disturbances. Furthermore, the neural network controller stabilizes human models of different statures from 1.4 to 2.2 m tall without any changes to the control parameters. Please see videos at the following link: 3D biped walking control.