bluuebunny/crossref_metadata_2025_split huggingface dataset:
Joint Analysis of Multiple Omics to Describe the Biological Characteristics of Resistant Hypertension
Authors: Wang Shanshan , Hu Yuanlong , Wang Yuqi , Song Yueyue , Liang Dan , Yin Jiufeng , Li Yunlun , Yang Wenqing , Zhang Dan 
Published: December 2024

AbstractResistant hypertension (RH) may cause severe target organ damage and poses significant challenges in the field of hypertension prevention and treatment. Mining biological characteristics is crucial for exploring the pathogenesis of RH and for early diagnosis and treatment. Although several single‐omics studies have been conducted on RH, its complex pathogenesis has only been partially elucidated. In this study, metabolomics, proteomics, and transcriptomics were jointly analyzed in healthy subjects and patients with hypertension and RH. The multi‐omics analysis found that differential substances of RH were enriched in the HIF‐1 signaling pathway and that differential substances such as ascorbic acid, reduced glutathione (GSH), choline, citric acid, transferrin receptor (TfR), Egl‐9 family hypoxia‐inducible factor 2 (EGLN2), and glutathione peroxidase 1 (GPX1) were screened out. The results of intergroup comparisons were as follows: RH versus N: ascorbic acid (Fold Change (FC):0.42, p < 0.01), GSH (FC:0.65, p < 0.05), choline (FC:1.32, p < 0.05), citric acid (FC:0.48, p < 0.001), TfR (FC2.32, p < 0.001), GPX1 (FC:16.02, p < 0.001), EGLN2 (FC:0.76, p < 0.001); RH versus EH: ascorbic acid (FC:0.52, p < 0.05), GSH (FC:0.55, p < 0.05), choline (FC:1.28, p < 0.05), citric acid (FC:0.59, p < 0.001), TfR (FC:1.71, p < 0.001), GPX1 (FC:2.11, p < 0.05), EGLN2 (FC:0.76, p < 0.05). These differential substances may reflect the biology of RH. This study provides multi‐omics analysis for a deeper understanding of the complex molecular characteristics of RH, providing new insights into the pathogenesis, early diagnosis, and precise treatment of the disease.
Association of constipation with all‐cause mortality among individuals with type 2 diabetes: A retrospective cohort study
Authors: Li Xianhua , Wen Haibin , Ke Jing , Zhao Dong 
Published: December 2024

ABSTRACTBackgroundConstipation is a common complication in type 2 diabetes mellitus (T2DM), yet its impact on mortality remains unclear. This study aimed to investigate the association between constipation and all‐cause mortality in patients with T2DM.MethodsWe conducted a retrospective cohort study using data from the National Health and Nutrition Examination Survey (NHANES) 2005–2010. Mortality outcomes were ascertained through linkage to National Death Index records until December 31, 2019. The association between constipation and all‐cause mortality was assessed using weighted Cox proportional hazards regression models. Kaplan–Meier curves were then employed to visualize survival probabilities. Effect modification was explored through stratified analyses and interaction tests.ResultsOf 1,339 participants with T2DM, 146 (10.90%) reported constipation. During a median follow‐up of 10.75 years, 411 deaths occurred (57 in the constipation group, 354 in the non‐constipation group). Fully adjusted weighted Cox regression analysis revealed that constipation was associated with increased all‐cause mortality (HR 1.50, 95% CI 1.01–2.22, P = 0.04). Kaplan–Meier analysis demonstrated a significantly lower survival probability in patients with constipation (log‐rank P < 0.05). Stratified analyses and interaction tests corroborated these findings across various subgroups.ConclusionsConstipation is associated with elevated all‐cause mortality risk in T2DM patients. These findings suggest that constipation management may be an important consideration in improving long‐term outcomes for individuals with T2DM.
The Influence of Caffeine on Tolerance to Sport‐Specific High‐Intensity Exercise in Young Elite Soccer Players
Authors: Bezuglov Eduard , Vakhidov Timur , Malyakin Georgiy , Kapralova Elizaveta , Emanov Anton , Koroleva Egana , Manina Marina , Erdes Svetlana , Talibov Oleg 
Published: December 2024

ABSTRACTBackgroundModern elite football places extremely high demands on the athlete's body, so it is of practical interest to study the effect of various dietary supplements on load tolerance and postexercise recovery. Furthermore, there is a lack of research on the effects of caffeine on key measures of load tolerance in football such as delayed‐onset muscle soreness (DOMS), rate of perceived exertion (RPE) and heart rate (HR) at different time points after the exercise.Methods54 young players aged 15–17 years from a leading Russian football academy took part in a randomised trial using the balanced placebo design. They were divided into 4 groups: 1 – told caffeine/given caffeine, 2 – told caffeine/given placebo, 3 – told placebo/given placebo and 4 – told placebo/given caffeine. All participants consumed two capsules 60 min before testing, each containing 200 mg of caffeine or placebo. Sprinting, counter‐movement jump, change of direction run, dribbling, T‐test and the repeated sprint ability test were used to create conditions for high‐intensity sports‐specific load. A visual analogue scale was used to assess the severity of muscle soreness. RPE was assessed using the Borg Rating of Perceived Exertion scale. HR immediately postexercise (HRpe), HR after 2 min of passive rest (HRrest) and recovery HR (HRrec = HRpe − HRrest) were obtained.ResultsThe data demonstrated that a single caffeine intake of 400 mg had no statistically significant effect on RPE (p = 0.948), HRpe (p = 0.698) or HRrec (p = 0.920) across the groups. Additionally, the severity of DOMS 24 h postexercise did not differ significantly between the groups (p = 0.077).ConclusionAcute caffeine ingestion does not affect the subjective and objective indicators of training load in young football players aged 15–17 years with low levels of anxiety and low levels of daily caffeine intake.
Incidence and influencing factors for surgical site infections after cesarean section in China: A systematic review and meta‐analysis
Authors: Guo Li , Huang Shujuan , Sui Hongmei , Li Weichao 
Published: December 2024

AbstractObjectiveThis study aims to estimate the overall incidence of surgical site infections (SSIs) after cesarean section (CS) and the influencing factors in the Chinese population.Materials and MethodsThe study searched all relevant literature in English and Chinese search databases (English search bases: PubMed, Embase, Cochrane Library, Web of Science; Chinese search bases: China National Knowledge Infrastructure, Wanfang, and China Science and Technology Journal Database) up to March 19, 2024, according to the search strategy. A random/fixed effects model was decided on the basis of the I2 statistic assessing the magnitude of study heterogeneity, and publication bias was assessed using the Begg's test.ResultsAfter the selection, a final selection of 25 articles was involved. The estimate of post‐CS SSIs in China was 2.4% (95%CI: 0.019, 0.029). Age ≥30 years (WMD: 3.8), pre‐pregnancy body mass index (BMI) ≥25 kg/m2 (WMD: 1.8), obesity (odds ratio [OR]: 3.0), vaginal cleanliness 3–4 (OR: 4.2), anemia (OR: 1.4), premature rupture of membranes (OR: 2.6), diabetes mellitus (OR: 2.7), National Nosocomial Infections Surveillance System 1–3 (OR: 5.6), emergency surgery (OR: 2.3), trial of labor (OR: 2.9), duration of surgery ≥60 min (OR: 2.0), and intraoperative blood loss >500 mL (OR: 3.5) were the risk factors for post‐CS SSIs.ConclusionsThe rate of post‐CS SSIs estimated was 2.4% in China. Both maternal conditions and surgical factors can potentially increase the risk of post‐CS SSIs.
Relationship between relaxin‐2 levels in serum and mode of conception in twin gestations: A prospective cohort study
Authors: Silvano Angela , Ammar Oumaima , Parenti Astrid , Strambi Noemi , Seravalli Viola , Bani Daniele , Di Tommaso Mariarosaria 
Published: December 2024

AbstractAimRelaxin is a peptide hormone commonly associated with pregnancy when it is thought to play a role in modulating various physiological processes to optimize maternal–fetal adaptation. In twin pregnancies these adaptive requirements are higher than in singleton pregnancies, therefore it is important to understand how circulating relaxin behaves in such conditions. This prospective cohort study aims to determine the serum relaxin‐2 levels throughout gestation in twin pregnancies and to investigate its association with the mode of conception.MethodsBlood samples were collected during each trimester of gestation from 26 women with twin pregnancies obtained through spontaneous conception (SC, n = 18) or assisted reproductive technologies, specifically through intracytoplasmic sperm injection (ART, n = 8). Serum relaxin‐2 levels were measured by a highly sensitive ELISA method.ResultsThe results indicated that serum relaxin‐2 level peaks in the first trimester (491.05 ± 207.41 pg/mL), then decreases in the second trimester (446.27 ± 180.4 pg/mL; p < 0.057) and in the third trimester (422.19 ± 194.30 pg/mL; p < 0.025). Interestingly, the serum relaxin‐2 level was higher in the spontaneous conception group with respect to the assisted reproductive technologies group (p < 0.001), when measured at each trimester of gestation. In addition, the multivariate regression analysis showed that only the assisted reproductive technologies had a significant impact on serum levels of relaxin‐2 (p < 0.001), and no significant association was found with other women's clinical and demographic characteristics.ConclusionsThese findings extend the current knowledge about the pattern of circulating relaxin‐2 throughout gestation in twin pregnancies, providing a sensitive measurement of serum relaxin‐2 levels and a description of its putative physiological roles in humans.
Anaphylactic Reactions During Bee Venom Immunotherapy in the Paediatric Population
Authors: Wong Jessica W. S. , Courtney Ashling , O'Gorman Tess , McKinnon Elizabeth , Noble Valerie , Itotoh Benedicta 
Published: December 2024

ABSTRACTAimA retrospective study will review episodes of anaphylaxis during bee venom immunotherapy (BVIT) in children, any modifications made to the dosing schedule, and the subsequent outcomes over a nine‐year period in Western Australia.MethodsPatient demographics, dose eliciting anaphylaxis during BVIT, modifications made to BVIT regimen following anaphylaxis (i.e., continuation, modification, or cessation), and the subsequent outcomes were collected for children commenced on BVIT from 1st September 2012 to 31st August 2021.ResultsA total of 624 children were commenced on BVIT from 2012 to 2021. 12/624 (1.9%) did not complete the recommended duration of BVIT, the majority of which were due to poor compliance. 33 children (5.2%) developed anaphylaxis. 2/33 children (6.0%) experienced anaphylaxis on multiple occasions, resulting in 36 separate episodes of anaphylaxis. Most of the anaphylactic episodes occurred on Day 1 of BVIT (56%). 23/35 children (65.7%) developed anaphylaxis during the build‐up phase and 12/35 children (34.3%) developed anaphylaxis during the maintenance phase. For those who experienced anaphylaxis in the build phase, 6/23 children (26.0%) continued with immunotherapy on the same day, and 5/6 of these children (83.3%) tolerated the same‐day continuation of immunotherapy; 17/23 children (73.9%) ceased immunotherapy and restarted on another day, with 11/17 children (64.7%) tolerating cessation and recommencement of the regimen on another day. For those who developed anaphylaxis during the maintenance phase, 6/12 children (50.0%) tolerated ongoing immunotherapy.ConclusionsChildren who experience anaphylaxis during the build‐up phase of BVIT showed a low risk of further anaphylaxis with proceeding immunotherapy on the same day. Children who experience anaphylaxis during the maintenance phase of BVIT appear less likely to tolerate ongoing immunotherapy due to the recurrence of anaphylaxis.
Trans‐Specific Polymorphisms Between Cryptic Daphnia Species Affect Fitness and Behavior
Authors: Murray Connor S. , Karram Madison , Bass David J. , Doceti Madison , Becker Dörthe , Nunez Joaquin C. B. , Ratan Aakrosh , Bergland Alan O. 
Published: December 2024

ABSTRACTShared polymorphisms, loci with identical alleles across species, are of unique interest in evolutionary biology as they may represent cases of selection maintaining ancient genetic variation post‐speciation, or contemporary selection promoting convergent evolution. In this study, we investigate the abundance of shared polymorphism between two members of the Daphnia pulex species complex. We test whether the presence of shared mutations is consistent with the action of balancing selection or alternative hypotheses such as hybridization, incomplete lineage sorting or convergent evolution. We analyzed over 2,000 genomes from six taxa in the D. pulex species group and examined the prevalence and distribution of shared alleles between the focal species pair, North American and European D. pulex. We show that North American and European D. pulex diverged over 10 million years ago, yet retained tens of thousands of shared polymorphisms. We suggest that the number of shared polymorphisms between North American and European D. pulex cannot be fully explained by hybridization or incomplete lineage sorting alone. We show that most shared polymorphisms could be the product of convergent evolution, that a limited number appear to be old trans‐specific polymorphisms, and that balancing selection is affecting convergent and ancient mutations alike. Finally, we provide evidence that a blue wavelength opsin gene with trans‐specific polymorphisms has functional effects on behavior and fitness in the wild.
Prevalence, Incidence and Risk Factors of White Spot Lesions Associated With Orthodontic Treatment – A Systematic Review and Meta‐Analysis
Authors: Hussain Umar , Wahab Abdul , Kamran Muhammad Abdullah , Alnazeh Abdullah Ali , Almoammar Salem , Alshahrani Shaya Saud Mohammed , Niazi Fayez Hussain , Alam Shamsul , Arif Nauman , Campobasso Alessandra , Pandis Nikoloas 
Published: December 2024

ABSTRACTThe primary objective was to systematically assess the prevalence, incidence and risk factors of WSLs with orthodontic treatment. The secondary objective was to compare the prevalence of WSLs between conventional fixed appliances (CFA) and other appliances, as well as with no treatment. PubMed, Scopus, Web of Science, LILACs, Virtual Health Library and Cochrane CENTRAL were searched. Risk of bias was assessed using RoB‐2, ROBINS‐I tool and the Joanna Briggs Institute Critical Appraisal Checklist. Random‐effects meta‐analyses of pooled proportions and odds ratios (OR) with 95% confidence intervals (CIs) were conducted, followed by meta‐regressions, sensitivity analyses, and an assessment of the quality of evidence using GRADE. Trial Sequential Analysis (TSA) was performed to determine the conclusiveness of the evidence. Fifty‐seven studies involving 9101 patients (mean age of 16.4 years, 33.5% male) were included. Among orthodontic patients, the pooled prevalence of WSLs was 55.06% (95% CI: 47.7%, 63.6%: 42 studies), incidence was 34.2% (95% CI: 27.6%, 40.6%: 44 studies) and surface prevalence was 26.9% (6 studies; 95% CI: 13.8%, 39.8%). Among non‐treated patients, the pooled prevalence of WSLs was 29.1% (95% CI: 17.2%, 41.1%; 21 studies). The odds of WSLs were significantly higher, with CFA being 4.73 times greater compared to other appliances (OR = 4.7, 95% CI: 1, 19.2, p = 0.05) and seven times higher compared to no treatment (OR = 7, 95% CI: 2.6, 18.5, p = 0.001). Prevalence of WSLs increased with longer treatment duration (p < 0.001), varied with ethnicity, being highest in Africans and lowest in Americans (p < 0.05), and method of detection (p < 00.1). TSA confirmed that CFA leads to more WSLs than other appliances or no treatment, with future studies unlikely to alter the direction of the outcomes. Orthodontic treatment increases WSL prevalence, influenced by various factors. Clinicians should carefully consider the development of WSLs during orthodontic treatment and adjust treatment plans accordingly, choose appliances wisely and monitor with effective detection tools. Since one‐third of untreated cases already have WSLs, proper documentation at treatment start is essential.Trail Registration: CRD42023478065
Parental and Child‐Reported Health‐Related Quality of Life in Pediatric Patients With Vascular Malformations
Authors: González‐Moreno Andrea Fernanda , González‐González Mónica Krysteel , Durán‐McKinster Carola , García‐Romero Maria Teresa 
Published: December 2024

ABSTRACTHealth‐related quality of life (HRQoL) in pediatric patients with vascular malformations (VaM) remains challenging to measure due to an absence of disease‐specific tools and limited correlation with clinical measures. In this cross‐sectional study of 50 children with VaM we evaluated self and parental‐reported physical and psychosocial HRQoL using the PedsQL tool and analyzed scores according to type of VaM and age categories. We found HRQoL is considerably decreased in children with VaM and perceived similarly by patients and their parents, except for those with simple VaM and ages 13–18 years, who scored physical domains better than their parents. These findings contribute to the adequate clinical care of children with VaM, underscoring the need to identify and understand factors affecting their HRQoL and to improve multidisciplinary care strategies.
‘You fine an industry, then return the funding to them’: State‐facilitated corporate crime and Colorado's Suncor Oil Refinery
Authors: Malin Stephanie A. , Luxton India , Beltrán Ramona , Ravetta Emilia , Hulama Kristina 
Published: December 2024

AbstractIn Commerce City, Colorado, residents contend with multiple environmental hazards and live in the most polluted zip code in the US. Perhaps no source of environmental harm is more visible than the imposing, aging Suncor Oil Refinery. The refinery dominates entire city blocks and residents' daily lives. Since 2005, the refinery has been cited for over nearly 60 environmental and safety violations. Despite this, it continues operating with minor penalties, exemplifying how the state's neoliberalized regulatory approaches prioritize corporate profit over social–environmental protections. We examine how the Suncor Oil Refinery creates harmful environmental injustices, representing a significant instance of state‐facilitated corporate crime, as the state leaves the industry to self‐regulate and violate (or operate without) permits. Bridging green criminology and environmental justice literatures, our findings emphasize the importance of recognizing state‐facilitated corporate crime as a key driver of environmental injustice. Drawing on interviews with 53 community members, educators, and elected officials, this study provides firsthand accounts of the detrimental effects of the refinery's operations on nearby residents and documents their lived experiences of environmental injustice. Our findings illustrate harmful impacts of state‐facilitated corporate crime and contribute to scant research examining people's experiences of harm from living or working near oil refineries.
Effects of different ecological planting modes of economic forests on soil infiltration characteristics in the Dabie Mountain area of China
Authors: Sun Lei , Wenqi Fan , Jamshidi Abdul Hakim , Zhiyang Dou , Yun Zhu , Guangcan Zhang , Liu Xia 
Published: December 2024

AbstractThe effect of different ecological planting modes of economic forests on soil infiltration characteristics is an essential topic for designing sustainable forest management practices. This study examined the soil infiltration characteristics of mono‐planting Chinese chestnut forest (MCF), Chinese chestnut‐tea intercropping (TCF) and Chinese chestnut forest with close‐to‐nature restoration (NCF) and compared them with mixed wood forest (MWF, the control) in Jinzhai County, which is located at the northern foot of Dabie Mountain. The basic soil properties and water infiltration characteristics of topsoil (0–20 cm) and subsoil (20–40 cm) were measured, and the main factors affecting soil water infiltration characteristics were analysed. The results showed that: (1) Compared with MWF, soil water infiltration rates of MCF, TCF and NCF were significantly reduced, and NCF had higher soil water infiltration rates than TCF; (2) After MWF was converted to MCF or TCF, soil bulk density of 0–40 cm increased significantly, and the soil clay content, organic matter, porosity, water content and aggregate stability decreased; (3) The response of topsoil properties to planting mode was higher than that of subsoil; (4) Correlation analysis showed that the amount of macroaggregate fraction (>0.25 mm), soil porosity and SOM were the most important factors affecting soil water infiltration characteristics of Chinese chestnut forest under different ecological planting modes in Dabie Mountain. Close‐to‐nature restoration of Chinese chestnut forest might be a proper planting mode to enhance soil water infiltration characteristics in the studied area.
Influence of knowledge, attitude and self‐efficacy on Opisthorchis viverrini and cholangiocarcinoma prevention: A One Health approach in high‐risk areas of Thailand
Authors: Busabong Worathon , Songserm Nopparat , Woradet Somkiattiyos , Sripa Banchob 
Published: December 2024

AbstractObjectiveOpisthorchis viverrini and cholangiocarcinoma have been recognised by the World Health Organisation as critical public health concerns, particularly in northeastern Thailand, where Opisthorchis viverrini is a significant cause of cholangiocarcinoma. This study examines the factors influencing Opisthorchis viverrini and cholangiocarcinoma prevention within the One Health framework in Kanthararom District, Sisaket Province, Thailand.MethodsA cross‐sectional study was conducted among 327 residents aged 20 and above, utilising a structured questionnaire to assess knowledge, attitudes, perceived self‐efficacy and prevention behaviours. Data were analysed using descriptive statistics, Pearson's product–moment correlation coefficient and multiple regression analysis to identify relationships and predictors within the dataset.ResultsThe results showed that 53.52% of participants had moderate knowledge and attitudes towards prevention, while perceived self‐efficacy was generally high. Positive correlations were found between income, knowledge, attitudes, self‐efficacy and prevention behaviours. Key predictors of Opisthorchis viverrini and cholangiocarcinoma prevention behaviours included attitudes towards human health (β = 0.212), perceived self‐efficacy in human health (β = 0.211), attitudes towards animal health (β = 0.205) and knowledge about human health (β = 0.138), accounting for 24.40% of the variance in prevention behaviours. These predictors were statistically significant at 0.05 (F = 25.95; p <0.001).ConclusionThe findings suggest that enhancing knowledge, attitudes and self‐efficacy is crucial to improving Opisthorchis viverrini and cholangiocarcinoma prevention. This study underscores the need for integrated public health strategies incorporating human, animal and environmental health to reduce the prevalence of Opisthorchis viverrini and cholangiocarcinoma in high‐risk regions.