bluuebunny/crossref_metadata_2025_split huggingface dataset:
“It sounds like elves talking” – Polish migrants in Aberystwyth (Wales) and their impressions of the Welsh language
Authors: Rosiak Karolina , Zydorowicz Paulina 
Published: July 2021

Abstract
The purpose of this paper was to gain a better understanding of the perceptions of the Welsh language held by the Polish adult migrants in Aberystwyth, Wales. Using qualitative research methods, we collected data from participants concerning their perceptions of the sound and spelling system of Welsh. Data obtained showed that adult Poles in Aberystwyth perceive the phonetics and phonotactics of Welsh to be markedly different from that of their native Polish. The participants believed Welsh to have small number of vowels and large number of consonantal clusters. By comparing consonantal and vowel inventories we were able to demonstrate that Welsh has a more complex vowel inventory than Polish. The consonantal inventories of both languages show great similarities and should not pose major problems to Polish learners of Welsh, who are also speakers of English. As for the phonotactics, Polish possesses a far more complex inventory of consonantal clusters than Welsh. We show that claims of the study’s participants that Welsh pronunciation is markedly different from Polish is not based on the linguistic grounds. Instead, such claims must be rooted in the social and ideological perceptions of the Welsh language on the part of the participants in the study.
Rational approaches towards inorganic and organometallic antibacterials
Authors: Hess Jeannine 
Published: July 2021

Abstract
The occurrence of drug-resistant bacteria is drastically rising and new and effective antibiotic classes are urgently needed. However, most of the compounds in development are minor modifications of previously used drugs to which bacteria can easily develop resistance. The investigation of inorganic and organometallic compounds as antibiotics is an alternative approach that holds great promises due to the ability of such molecules to trigger metal-specific mechanisms of action, which results in lethal consequences for pathogens. In this review, a selection of concepts to rationally design inorganic and organometallic antibiotics is discussed, highlighting their advantages by comparing them to classical drug discovery programmes. The review concludes with a short perspective for the future of antibiotic drug development and the role metal-based compounds will play in the field.
Solitons based optical packet switch analysis
Authors: Shukla Utkarsh , Singhal Niraj , Srivastava Rajiv 
Published: July 2021

Abstract
Due to the evolution of data centric applications demand for high speed data transfer and more bandwidth is increasing continuously. The unavailability of components like tunable wavelength converters (TWCs) restrict the transfer of parallel information using wavelength division multiplexing (WDM), therefore in the present scenario optical orthogonal frequency division multiplexing can be used. Moreover in optical communication narrow Gaussian pulses are transmitted, which spread with distance and leads to the broadening of the pulse and pulse peak power goes down and thus limits the system. In this paper a Soliton based optical communication system is proposed and its comparison with Gaussian pulse is presented and it has been found that soliton pulse has lesser bit error rate in comparison to Gaussian pulses.
Dosage escalation of antenatal steroids in preterm twin pregnancies does not improve long-term outcome
Authors: Braun Thorsten , Filleböck Vivien , Metze Boris , Bührer Christoph , Plagemann Andreas , Henrich Wolfgang 
Published: July 2021

Abstract

Objectives
To analyze long-term effects of antenatal betamethasone (≤16 mg, =24 mg and >24 mg) in preterm twins on infant and childhood morbidity.

Methods
Retrospective cohort study among 198 preterm twins. Three follow up time points, including a total of 84 outcomes, were evaluated: first neonatal examination after birth and in the neonatal period up to 10 days after birth using data from the clinic charts; examination from the 21st to the 24th month of life and examination from the 60th to the 64th months, using data from copies of the children’s examination booklets sent back by the parents. Dosage-dependent and sex-specific long-term effects of antenatal betamethasone treatment on neonatal, infant and early childhood development and morbidity up to 5.3 years of age were analyzed.

Results
Dosage escalation of >24 mg was not associated with improved neonatal, infant or early child hood outcome, independent of twin pair structure. In contrast, higher doses >24 mg were significantly linked to increased rates of congenital infections (OR 5.867, 95% CI 1.895–18.167). Male sex as a factor was obvious for lower rates of apnea-bradycardia-syndrome in neonates, higher rates of no free steps after 15 months in infancy and highest rates of motor clumsiness in early childhood.

Conclusions
Betamethasone dosage escalation >24 mg in twins born between 23+5 and 33+6 weeks of gestation did not improve neonatal, infant or early childhood morbidity. In contrast, higher doses >24 mg total dose resulted in significantly higher rates of congenital infections and are not recommended. For males, 24 mg betamethasone appears to be the preferable dose.
The Influence of Mother Wisdom on Augustine
Authors: Bouwman Kitty 
Published: July 2021

Abstract
The Book of Ben Sira was popular in the early Christian church and influenced the Church Father Augustine (354–430). He adopts the person of Wisdom as a divine mother and adapts her within the context of the early Christian church. He links to Mother Wisdom a wisdom theology, in which Jesus is her envoy. Augustine describes Mother Wisdom as an eternal nourishing divine mother. She has a permanent revelatory status by continuously giving life-giving power, which she mediates through Jesus of Nazareth. He presents her grace which she has prepared for the competentes (the candidates for Baptism), who are working towards initiation into Christian Faith. Mother Wisdom serves as hostess in biblical Wisdom literature. For Augustine, Jesus Christ has taken this place. Mother Wisdom serves instead the angels and the spiritual persons as a representative of divine nourishment.
Arsenic exposure promotes the emergence of cardiovascular diseases
Authors: Karachaliou Christiana , Sgourou Argyro , Kakkos Stavros , Kalavrouziotis Ioannis 
Published: July 2021

Abstract
A large number of studies conducted in the past decade 2010–2020 refer to the impact of arsenic (As) exposure on cardiovascular risk factors. The arsenic effect on humans is complex and mainly depends on the varying individual susceptibilities, its numerous toxic expressions and the variation in arsenic metabolism between individuals. In this review we present relevant data from studies which document the association of arsenic exposure with various biomarkers, the effect of several genome polymorphisms on arsenic methylation and the underling molecular mechanisms influencing the cardiovascular pathology. The corresponding results provide strong evidence that high and moderate-high As intake induce oxidative stress, inflammation and vessel endothelial dysfunction that are associated with increased risk for cardiovascular diseases (CVDs) and in particular hypertension, myocardial infarction, carotid intima-media thickness and stroke, ventricular arrhythmias and peripheral arterial disease. In addition, As exposure during pregnancy implies risks for blood pressure abnormalities among infants and increased mortality rates from acute myocardial infarction during early adulthood. Low water As concentrations are associated with increased systolic, diastolic and pulse pressure, coronary heart disease and incident stroke. For very low As concentrations the relevant studies are few. They predict a risk for myocardial infarction, stroke and ischemic stroke and incident CVD, but they are not in agreement regarding the risk magnitude.
Novel methodology for turbine gas meters error curve modelling across a wide range of operating parameters
Authors: Blagojevič Bogdan , Širok Brane , Bizjan Benjamin 
Published: July 2021

Abstract
In this paper, performance of turbine flowmeters was investigated for different flowmeter ranges and working gas operating pressures. Variation of these parameters was represented in dimensionless form as a function of Reynolds Number and gas density ratio, while the relative flow measurement error was selected as the most important operating characteristic. A novel error curve model based on turbine machine theory and dimensionless analysis was introduced for the purpose of error data fitting across a wide range of gas flow rates and operating pressures. The main advantage of the presented model is the capability of accurate error data fitting with a single continuous equation, as demonstrated by high

R

2

{R^{2}}

values for the vast majority of flowmeters analyzed in this study. The acceptability criterion was designed based on the fact that the expanded measurement uncertainty of the relative error must not exceed 0.5 %. Besides an accurate interpolation, our model can also be utilized for prediction of turbine flowmeter performance at modified flow conditions (pressure and flow rate, working gas properties), and for assessment of the drift of flowmeter performance over time. The novel error curve model is demonstrated to outperform the standard polynomial-based model regardless of the independent variable used.
Comparison of nitric oxide and adrenomedullin levels of children with attention deficit hyperactivity disorder and anxiety disorder
Authors: Karagöz Yüksel Sümeyra , Doğan Özlem , Elgün Serenay , Kılıç Birim Günay 
Published: July 2021

Abstract

Objectives
Many studies show that adrenomedullin (ADM) is associated with nitric oxide (NO) and various mechanisms and is involved in the etiopathogenesis of schizophrenia, bipolar disorder and autism by oxidative stress and HPA axis dsyregulation. The aim of this study comparison of nitric oxide and adrenomedullin levels in children with ADHD, AD and healthy control included in our study, especially due to their effect mechanisms as they may predict anxiety symptom, was to investigate the relationship between nitric oxide and adrenomedullin levels and anxiety symptoms in children with ADHD, AD and healthy control.

Methods
The study included 27 ADHD, 27 AD and 23 healthy children without any previous drug use, without comorbid disease. The semi-structured interview was conducted by the researcher in all the children attending the study. Sociodemographic information form, Conner’s Parent and Teacher Rating scale and State-Trait Anxiety Inventory (STAI) were evaluated. NO level measured by spectrophotometer, ADM levels were measured by ELISA.

Results
There was no statistically significant difference in the serum NO and ADM levels of the children included in the sampling group according to age and sex. There was no statistically significant difference between NO and ADM levels between ADHD, AD and control groups. There was no statistically significant relationship between serum NO and ADM levels and ADHD, AD and control group children of state-trait anxiety scores.

Conclusions
These findings may suggest that NO and ADM levels in children with ADHD, AD do not show these diseases and that these parameters are not associated with anxiety symptoms.
Adaptive total variation constraint hypergraph regularized NMF for single‐cell RNA‐seq data analysis
Authors: Zhu Ya‐Li , Zhang Xiao‐Ning , Wang Chuan‐Yuan , Liu Jin‐Xing , Kong Xiang‐Zhen 
Published: July 2021

BackgroundSingle‐cell RNA sequencing (scRNA‐seq) data provides a whole new view to study disease and cell differentiation development. With the explosive increment of scRNA‐seq data, effective models are demanded for mining the intrinsic biological information.MethodsThis paper proposes a novel non‐negative matrix factorization (NMF) method for clustering and gene co‐expression network analysis, termed Adaptive Total Variation Constraint Hypergraph Regularized NMF (ATV‐HNMF). ATV‐HNMF can adaptively select the different schemes to denoise the cluster or preserve the cluster boundary information between clusters based on the gradient information. Besides, ATV‐HNMF incorporates hypergraph regularization, which can consider high‐order relationships between cells to reserve the intrinsic structure of the space.ResultsExperiments show that the performances on clustering outperform other compared methods, and the network construction results are consistent with previous studies, which illustrate that our model is effective and useful.ConclusionFrom the clustering results, we can see that ATV‐HNMF outperforms other methods, which can help us to understand the heterogeneity. We can discover many disease‐related genes from the constructed network, and some are worthy of further clinical exploration.
Messianism and Modernity. Commentary to the Liturgy of History
Authors: Suskiewicz Marcin 
Published: July 2021

In his recent book Liturgia dziejów [Liturgy of History], Paweł Rojek argues that Karol Wojtyła was to a large extent influenced by Polish Messianism. Although Rojek’s argument centres around this rather historical thesis, his book is essential reading not only for students of John Paul II’s legacy but anyone interested in the relationship between Christianity and modernity. It is so, because Polish Messianism, according to Rojek, was an early project of Christian modernity. By taking inspiration from the Messianists, Wojtyła was able to combine religious perspective with modern anthropocentrism.
Jean-Paul II : messianisme ou universalisme éthique ?
Authors: Masłowski Michał 
Published: July 2021

Paweł Rojek in his book Liturgia dziejów [Liturgy of History] reveals the importance of the Polish romantic messianism for the thought of John Paul II. He carefully defends this tradition against the popular charge of heresy, and argue that in fact it preceded the formulation of Catholic social teaching and some crucial doctrines of the Second Vatican Council. In the longest chapter of his book, Rojek developes “Messianism of Work, ” an idea very close to me. For John Paul II the Eucharist was an inspiring symbol of cooperation of God and man in the history. In this paper, however, I rise some fundamental doubts concerning Rojek’s interpretation. First, he seems to adopt a false theology of nation in which nations are thought as kind of persons. Second, he suggests that John Paul II supported an alleged “third way” between communism and capitalism. Finally, he neglects the universalistic dimension of papal vision. In result, messianism in this interpretation might function not as dynamic universalistic utopia, but rather static, nationalistic ideology.
The historical dispute over Polish Messianism and John Paul II’s thought
Authors: Wawrzynowicz Andrzej 
Published: July 2021

The paper addresses the problem of historical role and impact of John Paul II’s teachings on the dispute over Polish messianism which has been consistently present in the Polish literature and philosophy over the past two centuries. The article is an attempt to determine the pope’s actual contribution to the development of the idea of Polish messianism, and evaluate the ultimate significance of this contribution within a broad perspective of the evolution of Polish political thought during the latter part of the twentieth and early decades of the twenty first centuries. The starting point in the discussion is the contemporary historical-philosophical research in this field, and the final conclusions are oriented towards the philosophical qualification of the most recent attempts to revive the messianist ideology on the basis of papal thought.
Dolor en adultos mayores de 80 años: características, impactos y estrategias de afrontamiento
Authors: Atílio Fernando Gustavo Cordeiro , Suzuki Augusto Furukawa , Damaceno Daniela Garcia , Alarcon Miriam Fernanda Sanches , Marin Maria José Sanches , Girotto Marcos Antonio 
Published: July 2021

Introducción: Como consecuencia del proceso de envejecimiento a nivel mundial y, en especial, en la población de adultos mayores, el cual está relacionado con los cambios en el proceso de senescencia, la prevalencia del dolor crónico ha aumentado exponencialmente. La presente investigación tiene como objetivo describir la presencia del dolor, sus características y las estrategias de afrontamiento entre los adultos mayores de 80 años. Materiales y métodos: Se realizó un estudio exploratorio cuantitativo descriptivo mediante la recolección de datos a través del instrumento Cuestionario Breve Del Dolor, además de datos sociodemográficos de 60 adultos mayores de 80 años que residían en el área de influencia de un equipo de Estrategia de Salud de la Familia ubicado en un municipio del centro occidente de Sao Paulo. Resultados: La muestra final contó con 60 adultos mayores con una media de 85.2 años, en su mayoría mujeres (64%), viudas (67%), de piel blanca (82%), jubiladas (67%) y con educación primaria completa (32%). Entre los participantes, el 73% presentó dolor en la última semana con repercusiones importantes en su vida diaria. El dolor se localiza frecuentemente en las extremidades inferiores e interfiere de forma moderada o intensa en la realización de las actividades cotidianas. Se observó que el 48% de los adultos mayores recurren a la implementación de medidas farmacológicas y no farmacológicas para el alivio del dolor con resultados satisfactorios. Conclusiones: El afrontamiento del dolor en esta población requiere un enfoque multifactorial e integral que involucre la atención interdisciplinar y el apoyo familiar. Se supone que la presencia de dolor entre los adultos mayores de 80 años es alta, lo que interfiere con su vida diaria, pero que encuentran alivio mediante la implementación de medidas farmacológicas y no farmacológicas.
Como citar este artículo: Atílio, Fernando Gustavo Cordeiro; Suzuki, Augusto Furukawa; Damaceno, Daniela Garcia; Alarcon, Miriam Fernanda Sanches; Marin, Maria José Sanches; Girotto, Marcos Antonio. Dor no idoso acima de 80 anos: características, impactos e estratégias de enfrentamento. Revista Cuidarte. 2021;12(2):e1310. http://dx.doi.org/10.15649/cuidarte.1310
A clinical case of using therapeutic plasma exchange for the treatment of recurrent focal segmental glomerulosclerosis in a child after kidney transplantation
Authors: Miloserdov I. A. , Bogdanov V. S. , Gadzhieva P. M. , Saydulaev D. A. , Kartashev A. A. , Kulikova E. G. , Pashkova I. E. 
Published: July 2021

Background. Focal segmental glomerulosclerosis (FSGS) of the graft in kidney recipients is a rare and difficultto-diagnose post-kidney transplant complication, which can lead to graft loss and death of the recipient. A unified protocol is required for the treatment of this disease.Materials and methods. A 15-year-old female patient C. diagnosed with stage 5 chronic kidney disease as a result of steroid-resistant nephrotic syndrome with hematuria underwent a living related-donor kidney transplantation. On the third day after the operation, laboratory and imaging data showed kidney graft dysfunction. Patient examinations established the cause of the graft dysfunction – idiopathic nephrotic syndrome in FSGS.Results. For the treatment of recurrent FSGS, the patient had her immunosuppressive therapy converted from tacrolimus to cyclosporin A, and received two 500 mg rituximab injections. Ten sessions of therapeutic plasma exchange (Plasauto Sigma) were performed to remove antibodies to podocytes. During the therapy, diuresis was restored, creatinine and urea levels decreased. Six months after the kidney transplant, graft function was fully restored. Conclusion. The absence of recurrent FSGS within six months during a single course of therapeutic plasma exchange with its subsequent cancellation after restoration of graft function allows to recommend the developed method for the treatment of FSGS in pediatric patients after kidney transplantation.
Clinical Features of Myasthenia Gravis Patients’: The assessment of 138 Patients
Authors: PANPALLI ATEŞ Mehlika 
Published: July 2021

Aim: The aim of this study was to evaluate the demographic characteristics, clinical presentation, antibody, and electrophysiological characteristics of patients with the diagnosis of Myasthenia Gravis (MG).
Materials and Methods: The demographic characteristics, clinical presentation, antibody, electrophysiological and radiological (thoracic tomography) characteristics of the patients who were followed in the Neuromuscular and Muscular Diseases Polyclinic of the hospital between 2014-2019 were analyzed.
Results: The mean age of the patients was 53.8±16.67 years. The mean disease duration was 4.8±5.05 years. Ptosis was the most common complaint in 79% (n=109) of our patients. The number of patients followed as pure ocular MG was 61.6% (n=85). There were 26 patients who presented with ptosis or diplopia at the first presentation and follow-up generalized MG with bulbar findings and weakness. Acetylcholine receptor antibody (AntiAChRAb) positivity was found in 78.3% (n=108) of the patients and thymus pathology was detected in thorax tomography in 37.7% (n=52).
Conclusions: The initial complaint provides little insight into the course of the disease. The important factor is clinical follow-up. Although MG treatment is known, the pathophysiology of MG remains to be elucidated, and other autoimmune conditions cause changes in treatment choice. Clarifying the pathophysiology of MG will enable the development of more effective diagnostic and treatment methods.
BLENDED LEARNING NA PROMOÇÃO DE APRENDIZAGEM ATIVA NA FORMAÇÃO EM SERVIÇO
Authors: Dos Santos de Assis Mario , Paulino Abranches Sérgio 
Published: July 2021

As Tecnologias Digitais de Informação e Comunicação (TDICs) abrem novas possibilidades de articular teoria-prática na formação em serviço para adultos, por meio da combinação de ensinos presencial e on-line, com o modelo pedagógico do blended learning (BL). O presente artigo relata a experiência da Escola Judicial do Tribunal Regional do Trabalho da Sexta Região (EJ-TRT6) com uso do BL em suas ações formativas em serviço. Desafios encontrados, contexto e estratégia de implantação e cenário atual do modelo implantado são relatados no estudo. Com abordagem qualitativa, de natureza descritiva por meio de relato de experiência, a pesquisa ampara-se no referencial teórico da andragogia (KNOWLES; HOLTON III; SWANSON, 2005), das metodologias ativas de ensino (BACICH; MORAN, 2017; CORTELAZZO et al., 2019) e do BL (GRAHAM, 2006; HORN, STAKER, 2015; MUBAYRIK, 2018).O estudo conclui que o BL foi incorporado à cultura organizacional da instituição por possibilitar participação ativa do aluno na construção do conhecimento, com uso de TDICs e de tarefas de aprendizagens vinculadas ao contexto de trabalho.