bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between body mass index and disease activity in patients with systemic lupus erythematosus from China
Authors: Li Hanchao , Du Xinru , Lv Xiaohong , Hao Zhiming , He Lan 
Published: December 2024

Abstract

Objective
To assess the association between clinical indicators (primarily Body Mass Index, BMI) and disease activity in systemic lupus erythematosus (SLE) populations in a large population-based cohort.
Methods
Four hundred consecutive patients with SLE were studied to determine the relation among clinical features, inflammatory and biochemical indicators, and parameters of disease activity. Significance values have been adjusted by Bonferroni correction for multiple tests, then differences between continuous variables were analysed by Kruskal Wallis tests. Multivariate analyses were carried out by multiple linear regression models.
Results
Four hundred SLE patients were included in the study, including 375 women and 25 men. 61 patients (15.25%) were underweight (BMI<18.5 kg/m²), 267 patients (66.75%) had a normal BMI (18.5 kg/m²≤BMI<25 kg/m²), and 72 (18.00%) were overweight (BMI ≥ 25kg/m²). BMI was negatively correlated with SLE disease activity index (SLEDAI) score (ρ=-0.11, P = 0.02) and positively correlated with inflammatory index complement component 3 (C3, ρ = 0.19, P = 1.16x10^-4). Patients in underweight group had the highest proportion (14.8%) of moderate to severe disease activity (SLEDAI ≥ 10) compared to normal weight (3.4%) and overweight (1.4%) patients. SLEDAI score, Anti-dsDNA, C3, WBC count, ALT, NEUT and HGB were significantly different between the underweight group and the other two groups.
Conclusions
These findings suggest that SLE patients with low BMI have higher disease activity, which means low BMI exerted a negative impact on disease activity in SLE patients. Causal relation between disease activity and BMI requires further investigation.
Comparison of Passive Ultrasonic and Sonically Activated Irrigation Methods: An Investigation Based on PGE2, NO and IL-6 Levels
Authors: Ersahan Seyda , Fatih Ozcelik , Findikci Sertan , Hepsenoglu Yelda Erdem , Degirmencioglu Duygu , Usta Aslı 
Published: December 2024

Abstract

The effectiveness of Passive Ultrasonic Irrigation(PUI) and Sonically Activated Irrigation(SAI) techniques was investigated in apical periodontitis(AP) patients based on changes in prostaglandin E2(PGE2), nitric oxide(NO), and interleukin-6(IL-6) levels. Sixty-six AP patients and thirty healthy controls were enrolled. Preoperative gingival crevicular fluid(preGCF) PGE2, NO and IL-6 levels were measured before treatment. After chemo-mechanical preparation, teeth were assigned to two groups according to final irrigation protocol[PUI(n:33) and SAI(n:33)]. The same markers were again measured 1 week after treatment(postGCF) and also 1st order most commonly seen bacteria(FMCB) typing was performed on microbial samples of the patients. PostGCF-PGE2 levels of the PUI group were lower than postGCF-PGE2 levels of the SAI group(p = 0.0335). Both postGCF-PE2 and IL-6 levels of the PUI group were significantly decreased after treatment(p < 0.0001), while only postGCF-PE2 levels decreased in the SAI group(p = 0.0316). The PUI system significantly reduced PGE2 and IL-6 levels by better controlling inflammation in the treatment of AP.
The possibility of using the APACHE II score in prognosis of the development of post-operative complications in the elderly with hip fractures
Authors: Bujakovic Tarik , Delibegovic Samir 
Published: December 2024

Abstract

Purpose A large number of patients with hip fractures develop postoperative complications. The APACHE II score has been shown its usefulness in surgical patients. We undertook a study to establish the ability of the APACHE score to assess the prediction of postoperative complications in patients over 65 years old with hip fractures, and to compare them with specific scoring systems developed for orthopaedic patients, and the general ASA Score and the Charlson Comorbidity Index (CCI) index.
Methods In order to test the score we used a prospective, cohort study in a tertiary care hospital with 410 consecutive patients aged ≥65 years old with hip fractures. The ASA score, CCI, the Nottingham Hip Fracture Score (NHFS), the POSSUM-P and the Acute Physiology and Chronic Health Evaluation (APACHE) II scores were tested. All complications up to 6 months post-operatively were registered. We categorized the complications according to the Clavien-Dindo Score as minor (1-2) or major (3-5) and we analysed the major post-operative complications.
Results The sensitivity and specificity of APACHE score and the P-POSSUM scores were 53.2 and 90.0, and 73.8 and 72.9, respectively. The area beneath the ROC curve was better for P-POSSUM than APACHE II, but the difference was not statistically significant. Both the P-POSSUM and APACHE II scores were statistically significantly better than ASA, the Nottingham score and CCI.
Conclusion This study showed that APACHE II and POSSUM-P can be used to predict postoperative complications in elderly people with hip fractures.
Epidemiological Profile of Benign and Malignant Central Nervous System Neoplasms in Brazil: A Decadal Analysis
Authors: Bark Bruno Ale , Costa Antônio Nogara Ferreira da , Segnori Bruno Henrique Mota , Martineli Enzo Figueiredo , Bark Guilherme Dorabiallo , de Araujo João Pedro Gorski Ribas , Bark Samir Ale , Scalzo Sofia Daczuk 
Published: December 2024

Abstract

Purpose
To analyze the epidemiological profile of benign and malignant CNS neoplasm patients in Brazil from 2014 to 2024 to inform public health.
Methods
A retrospective, cross-sectional study analyzed data from DATASUS on CNS neoplasm hospitalizations in Brazil from January 2014 to January 2024, using variables such as gender, race, age group, and geographic distribution. Patients lacking race data (33,583) were excluded from the analysis of racial disparities in CNS neoplasm morbidity.
Results
Malignant brain neoplasms (72%) had a higher prevalence compared to benign cases. Male patients had a greater incidence of malignant tumors, while benign tumors were more common in women. The Southeast region recorded the highest number of hospitalizations, highlighting regional disparities in healthcare access. Racial disparities were also noted, with white patients most affected by malignant neoplasms. The study underscores the need for public health policies focusing on early detection, equitable healthcare access, and addressing regional and racial inequalities in treatment outcomes.
Conclusion
This study highlights the predominance of malignant CNS neoplasms in Brazil, regional healthcare disparities, and demographic influences, emphasizing the need for public health strategies focused on early diagnosis, treatment, and equitable resource distribution for vulnerable populations.
Epigenetic-modification associated hnRNPA3 acts as a prognostic biomarker and promotes malignant progression of HCC
Authors: Cai Xufan , Guo Weihui , Wu Fang , Xu Weilang , Ding Tao , Diao Yizhe , Wang Lei , Qian Zhenyuan , Song Guangyuan 
Published: December 2024

Abstract

Objective
hnRNPA3 is highly expressed in numerous malignancies, including hepatocellular carcinoma (HCC), but its function and mechanism has not been elucidated. In this study, we performed a comprehensive bioinformatics analysis of hnRNPA3 in the TCGA-LIHC dataset and several experiments in vitro to investigate the function and potential mechanisms of hnRNPA3 in HCC.
Methods
Pan-cancer expression including hnRNPA3 levels as well as DNA methylation, associated ceRNA, immune infiltration, and immune checkpoint genes of hnRNPA3 in TCGA-LIHC dataset were assessed. Logistic regression, receiver operating characteristic curve (ROC), Kaplan-Meier analysis, and nomogram modeling were used to evaluate prognostic values of hnRNPA3 in HCC. hnRNPA3 level in cell subtypes in HCC tumor microenvironment was analysed through spatial transcriptomic. “pRRophetic” package was used to predict potential chemotherapeutic drugs sensitivity. hnRNPA3 level in HCC patients and cell lines were detected by qRT-PCR or WB. hnRNPA3’s impact on proliferation, migration were studied in SNU449 and HuH7 cell lines. RNA-seq showed hnRNPA3 controled different important singaling passways in HCC.
Results
hnRNPA3 was significantly elevated in HCC tumors compared to controls. hnRNPA3 levels correlated with Age, HCC stage, histologic grade, and tumor status, and may independently predict the overall and disease-specific survival. Significant associations were found between hnRNPA3 levels and DNA methylation. hsa-miR-22-3p may act as a regulatory factor for hnRNPA3 and form a ceRNA network with multiple lncRNAs.Analysis of immune infiltration and immune checkpoint genes revealed a correlation between hnRNPA3 expression and macrophages. The similar conclusion also occurred in the spatial transcriptomic detection. 5-Fluorouracil, Doxorubicin, Etoposide, et al, may be potential sensitive drugs in therapy of high-hnRNPA3 HCC patients. Silencing hnRNPA3 expression in SNU449 and HuH7 cells resulted in reducing proliferation and migration. RNA-seq showed hnRNPA3 played an important regulatory role in the malignant progression of HCC.
Conclusion
hnRNPA3 was found to represent a promising biomarker within HCC diagnosis and prognosis and maybe a potential drug-target in HCC therapy.
Percutaneous posterior full-endoscopic cervical foraminotomy and discectomy (PECFD) for ASD after anterior cervical decompression and fusion
Authors: Li Shun , Liu Yang , Huang Shuai , Chen Jianchong , Ding Ding , Ru Bin , Ji Zhongwei , Liu Wenlong , Guo Ran , Hu Jiaqi , Zhang Nannan , Xu langhai , Xu Yun , Wan Quan 
Published: December 2024

Abstract

The purpose of this study was to evaluate the clinical effect of percutaneous posterior full-endoscopic cervical foraminotomy and discectomy (PECFD) for treating degenerative diseases of adjacent cervical segments in patients who have undergone anterior cervical decompression and fusion(ACDF). Method: A retrospective observational study was performed between July 2021 and November 2023 on all patients treated with PECFD for adjacent segment disease (ASD) after ACDF. Clinical outcomes were assessed using a visual simulation scale, modified MacNab criteria, and radiological results. Results: Twelve patients (4 women, 8 men) were enrolled in the study. All patients had achieved good clinical results with PECFD. Post-surgical MRI results showed that all patients achieved complete clearance of the nucleus pulposus and significant improvement in both the angle of cervical lordosis and the height of the intervertebral space. The postoperative Japanese Orthopedic Association (JOA) scores had significantly improved (preoperative vs postoperative day 1, P = 0.01), neck disability index (NDI) score had significantly decreased (preoperative to postoperative day 1, P < 0.001), and the visual analogue scale (VAS) scores for neck pain and arm pain had significantly decreased (P < 0.05) (P = 0.01, P = 0.02, respectively) in all patients. One patient had recurrent ASD. Conclusion: PECFD may be considered as an effective and safe option for the treatment of degenerative diseases at adjacent cervical segments. The advantage of this approach is that it not only provides an effective and safe way to treat cervical ASD, but also minimizes risk of iatrogenic injury.
Parkinson’s disease patients treated with levodopa exhibit a different pattern in the expression of emerging cytokines, IL-35 subunit and IL-37, compared to control group: A statistical analysis using Bayesian regression model
Authors: Gavabari Fariba Akbari , Rastegari-Pouyani Mohsen , Afshar Saeid , Bahramian Armin , Shahidi Siamak , Talebi-ghane Elahe , Chalabi Mahsa , Eftekharian Mohammad Mahdi , Mazdeh Mehrdokht 
Published: December 2024

Abstract

Background
Parkinson's disease (PD), is known as one of the most common neurodegenerative diseases in the world, which is characterized by the destruction of dopaminergic neurons in the substantia nigra of the midbrain. In the pathogenesis of this disease, central and peripheral inflammation play important roles. This study was done to investigate the expression of IL-35 (including P35 and Ebi3 subunits) and IL-37 genes, as well as the serum levels of IL-35 in patients with Parkinson's disease.
Methods
Peripheral blood samples were collected from 34 PD patients and 34 healthy individuals as a control group. IL-35 and IL-37 gene expression was measured using qRT-PCR technique and IL-35 serum level was measured by ELISA method. Advanced statistical analyzes were also performed using Bayesian regression in R software.
Results
The results showed that of the two subunits that make up IL-35, the expression of P35 gene was not significantly different between the two groups, while Ebi3 as well as IL-37 transcript levels were significantly lower in patients compared to healthy individuals (p < 0.001). On the contrary, IL-35 serum level in patients showed a significant increase compared to the control group (p = 0.016). It was also found that the decrease in IL-37 gene expression was related to the age of the studied subjects (p = 0.004). In addition, the results of correlation analysis showed positive and significant correlations between the expression of P35 gene with Ebi3 and IL-37, as well as Ebi3 with IL-37. Finally, based on ROC curve results, Ebi3 and IL-37 were introduced as appropriate factors with the potentials to be used in the diagnostic panels of PD.
Conclusion
In general, the findings of this study showed the complexities of immune system regulation and its disruption in PD
Effect of Autologous Dendritic Cell Administration on Changes in Renal Hemodynamics and Inflammatory Biomarkers in Diabetic Kidney Disease Patients
Authors: Drajat Endang , Jonny Jonny , Lokeswara Aditya Pratama , Daulay Elvita Rahmi , Icksan Aziza Ghanie , Farhat Farhat , Putranto Terawan Agus 
Published: December 2024

Abstract

Purpose Chronic hyperglycemia in DKD increases proinflammatory cytokines that can cause fibrosis and affect renal hemodynamics. This study aims to evaluate the effect of autologous dendritic cell administration in DKD patients, assessed by Doppler ultrasound examination (PSV and EDV), and measurement of TGF-β and MMP-9 biomarkers. Methods This study was a one group pretest posttest with 29 DKD patients. Measurement of PSV and EDV blood flow using doppler ultrasound, as well as blood collection for TGF β and MMP 9 biomarkers were performed before and after administration of autologous dendritic cells. Results The results showed that before administration, the median PSV value was 47.1 ± 23.87 cm/s, which decreased to 27.85 ± 20.53 cm/s with a p-value of 0.044, and EDV increased from 13 ± 5.32 cm/s to 15.7 ± 12.55 cm/s with a p-value of 0.039. The female group showed a significant decrease in PSV with a p-value of 0.03 and a significant increase in EDV with a p-value of 0.044. The microalbuminuria group showed a significant decrease in PSV with a p-value of 0.011. Analysis of TGF β and MMP 9 showed before administration of autologous dendritic cells, each increase of one unit of MMP 9 increased TGF β by 13.112, and after administration, it became 7.622. Conclusion This study shows that the administration of dendritic cells can improve renal hemodynamics and, in the long term, is expected to reduce fibrosis in the kidney.
Discovery of a non-Hermitian phase transition in a bulk condensed-matter system
Authors: Fiebig Manfred , Li Jingwen , Turaev Michael , Matsubara Masakazu , Kliemt Kristin , Krellner Cornelius , Pal Shovon , Kroha Johann 
Published: December 2024

Abstract

Phase transitions are fundamental in nature. A small parameter change near a critical point leads to a qualitative change in system properties. Across a regular phase transition, the system remains in thermal equilibrium and, therefore, experiences a change of static properties, like the emergence of a magnetisation upon cooling a ferromagnet below the Curie temperature. When driving a system far from equilibrium, novel, otherwise inaccessible quantum states of matter may arise. Such states are typically non-Hermitian, that is, their dynamics break time-reversal symmetry, a basic law of equilibrium physics. Phase transitions in non-Hermitian systems are of fundamentally new nature in that the dynamical behaviour rather than static properties may undergo a qualitative change at a critical, here called exceptional point. Here we experimentally realize a non-Hermitian phase transition in a bulk condensed-matter system. Optical excitation creates charge carriers in the ferromagnetic semiconductor EuO. In a temperature-dependent interplay with the Hermitian transition to ferromagnetic order, a non-Hermitian change of the relaxation dynamics occurs, manifesting in our time-resolved reflection data as a transition from bi-exponential real to single-exponential complex decay. Our theory models this behavior and predicts non-Hermitian phase transitions for a large class of condensed-matter systems, where they may be exploited to sensitively control bulk-dynamic properties.
Bilateral complete duplex system with right intravesical &amp; left extravesical ureteroceles. A case report from tertiary care hospital
Authors: Gebreziher Yirgalem , Zeru Enderta , Negash Hadush , Teshome Zeamanuel 
Published: December 2024

Abstract

Introduction: Bilateral duplex system with ureteroceles is one of the rarest entities in urology. Duplex collecting system is a common urologic anomaly with a wide range of clinical symptoms and a variety of associated urologic abnormalities such as an ectopic ureter, ureterocele, vesicoureteral reflux and ureteropelvic junction
Presentation of case: We present a 12-year-old male adolescent presented with nocturnal enuresis since birth and right flank pain of 8 months duration.
Clinical findings and investigations: There were no pertinent physical findings. A complete blood count, renal function test, urine analysis, ultrasound of the abdomen and pelvis, computed tomography urography, and cystoscopy were performed.
Intervention and outcome: A single-setting right upper pole heminephroureterectomy and left ureteropyelostomy were performed. He is now asymptomatic and regularly followed up on an outpatient basis.
Relevance and impact: This case report shows the safety of simultaneous open bilateral procedures for complete bilateral duplex systems in resource-limited settings.
What are community perspectives and experiences around GLP-1 receptor agonist medications for weight loss? A cross-sectional study in the UK
Authors: Auerbach Nadja , Liu Vivian N , Huang David , Clift Ashley K , Al-Ammouri Mahmoud , El-Osta Austen 
Published: December 2024

Abstract

Introduction
Obesity is a critical public health challenge globally. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have demonstrated significant efficacy in weight loss, but their adoption is influenced by various individual and societal factors. This study sought to examine awareness, motivations and barriers to adoption of GLP-1RAs in the UK, with a focus on demographic differences.
Methods
A cross-sectional survey of 1,297 UK adults was conducted using an electronic questionnaire distributed via social media, online platforms and personal networks. The survey assessed demographic characteristics, awareness, perceptions and use of GLP-1RAs. Data were analysed using chi-squared tests, Kruskal-Wallis tests and relative risk ratios (RRRs) from multinomial logistic regression. A p-value <0.05 was considered significant.
Results
Significantly higher awareness of GLP-1RAs was observed among those attempting weight loss in the past year (85.7% vs. 14.3%, p < 0.001). [vv1] Women were more most likely to report both awareness (87.2% vs. 68.2%, p < 0.001) and excellent understanding (20.0% vs. 7.5%, p < 0.001). Main information sources included news (60.1%) and social media (50.2%). Only 9.0% first learned about GLP-1RAs from healthcare providers. Past and current users were less likely than non-users to express scepticism about safety and efficacy, and 6.91 times more likely to strongly disagree that "risks outweigh the benefits" (RRR 6.91; 95% CI 4.32–11.05; p < 0.001) and 7.33 times more likely to strongly disagree that "there is not enough evidence to suggest GLP-1RAs are safe" (RRR 7.33; 95% CI 4.05–13.27; p < 0.001). 91.0% of current/past-users indicated they would recommend GLP-1RAs to a friend struggling with weight.
Conclusion
Concerns about safety, cost and potential side effects remain significant barriers to GLP-1RA adoption. Current/past users strongly disagree with statements of scepticism, however scepticism among non-users highlights the need for improved public education around safety and efficacy.
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Nutrient-Wide Associations with the Cardiometabolic Index in Older Adults: Insights from NHANES 2007–2016
Authors: Li Wen , Liu Siqi , Meng Xiaoxia , Liu Huaman 
Published: December 2024

Abstract

Background: The cardiometabolic index (CMI) is an innovative composite marker integrating adiposity and lipid metabolism, serving as a surrogate endpoint for chronic disease and mortality risks. This study employed a nutrient-wide association study (NWAS) approach to explore the associations between dietary nutrients and CMI in older U.S. adults.
Methods: Data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007–2016 were analyzed, including 2,673 participants aged ≥ 65 years. Multivariable linear regression adjusted for energy intake and traditional confounders was used to evaluate 56 dietary nutrients. Restricted cubic spline analyses assessed nonlinear dose-response relationships.
Results: Carbohydrate and total sugars were positively associated with CMI (Carbohydrate: Coefficient = 0.001, Adjusted P= 0.016; Total sugars: Coefficient = 0.001, Adjusted P = 0.021). In contrast, vitamin E and MFA 20:1 (eicosenoic acid) exhibited inverse associations with CMI (Vitamin E: Coefficient = -0.007, Adjusted P = 0.021; MFA 20:1: Coefficient = -0.129, Adjusted P = 0.035). Restricted cubic spline analyses revealed significant nonlinear relationships for vitamin E (P-nonlinearity = 0.043) and MFA 20:1 (P-nonlinearity = 0.028), identifying intake thresholds for protective and detrimental effects.
Conclusion: These findings underscore the complex interplay between diet and cardiometabolic risk, highlighting the potential of targeted nutritional interventions to reduce disease burden and improve health outcomes in aging populations. Further research is warranted to validate these findings and inform dietary guidelines.