bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Development of Online Training Curriculum base on Micro Learning and Online Social Network for Teacher in 21st Century in Test Construction Topic
Authors: Panwasn Mahalawalert, Areeya Sriprasert Ruangdech Sirikit, 
Published: February 2021

The objectives of this research were 1) to develop the online training curriculum based on Micro Learning and Online Social Network for 21st century teachers on test creation, and 2) to evaluate the effectiveness of the online training curriculum based on Micro Learning and Online Social Network for 21st century teachers on test creation. The methodology was divided into 2 steps:Step 1was the development of the online training curriculum based on Micro Learning and Online Social Network for 21st century teachers on test creation by studying the problems and demands in examination creating including the demand on online training for Bangkok schools’ teachers and executives using questionnaires. After that the information data gained from step 1 was used to design and develop the training curriculum then quality checked by the expert. The result found that the developed online training curriculum was in the highest suitability level. Step 2 was the effectiveness evaluation of the online training curriculum based on Micro Learning and Online Social Network for 21st century teachers on test creation by using the developed training curriculum with 30 Bangkok teachers from simple random sampling from the respondents in step 1 and willing to participate in online training on test creation.
The result found that 1) the evaluation on the teachers’ test creation ability compared to the ability before and after joining the training from development scores of each trained teacher – 2 teachers (6.67%) performed very high development, 21 teachers (70.00%) performed high development and 7 teachers (23.33%) performed moderate development and 2) the quality evaluation in accordance with the assessment standards of The Joint Committee on Standards for Educational Evaluation which was evaluated by 30 participating teachers and executives of the 30 teachers were in good level for 4 standards. The standard with the highest mean was propriety standards ( ̅̅ = 4.78). The next one was feasibility standards ( ̅= 4.74), Utility standards ( ̅= 4.71) and accuracy standards ( ̅= 4.64), respectively.
Correlation of Supervision Process and the Performance of the Graduate Program in Faculty of Education Mahachulalongkornrajavidyalaya University
Authors: Et al. Boonchurd  Chumnisart 
Published: February 2021

The objectives of this research were 1) to study the supervision process and the performance of the graduate program, 2) to study the correlation of the supervisory components and the performance of the graduate program, 3) to assess the supervision process related to the performance of the graduate program in Faculty of Education Mahachulalongkornrajavidyalaya University with empirical data. Mixed methods research was designed. Research sample consisted of 500 samples, and research tools were interview form and questionnaires. Data were analyzed by using descriptive statistics, Pearson correlation analysis, and analyzed factors of the supervision and the performance by computer software packages. Research results indicated that 1) appropriate supervision process and the performance of graduate programs were classified into five main processes, 64 sub-processes. 2) All supervisory and performance components were significantly correlated at the .001 level, with a correlation coefficient range from .054 to .620, which able to be analyzed for the process. 3) The validation of the supervision process related to the performance of the graduate program in Faculty of Education Mahachulalongkornrajavidyalaya University found that it was fit with empirical data, and analysis results were x2 = 103.82, df = 84, p = 0.07, Goodness of Fit Index (GFI) was .98, Adjusted Goodness of Fit Index (AGFI) was 0.94, Root Mean Square Residual (RMR) was .14 and Root Mean Square Error of Approximation (RMSEA) was .02, indicating that the model was consistent with the empirical data. Therefore, the supervision process correlated to the performance of the graduate program
The Extradition Measures under International Agreements in the Ineffectiveness of the Relevant Internal Law for the Enforcement of Detention of Suspects
Authors: Nantawaroprai Dolnapa 
Published: February 2021

Extradition is an international process which states expect to achieve the goal an accused brought to justice in territory of a requesting state where such person has committed a crime. However, there are a number of factors affecting extradition and causing it to be ineffective, such as diplomacy, politics, and so on. Therefore, states should seriously cooperate in the extradition with sincerity.
Socio- Political Education and Women Empowerment in Buddhist Perspective
Authors: Et al. Sitthiporn Khetjoi 
Published: February 2021

The purpose of research was to study the socio-political education and women empowerment in Buddhist perspective. The researchers studied and collected the data from Buddhist scriptures, texts, and related document about socio-political education and women empowerment in Buddhist perspective and analyzed by using content analysis. The results indicated that For decades, women have been parts of the supply of cheap, unskilled or semi-skilled labors for the industrial and service sectors. Gender discrimination continues even in the present times. At the same time, the problems of rural and urban lower-class women cannot be ignored. The empowerment of women is one of the solutions to the problems of inequality, subordination and marginalization that women face in the society. However, this kind of empowerment is only partial for all though they have economic and political power, they are kept out of decision making or they are dependent on their husband, father or brother for crucial decisions. Buddhism accepts that every human being, independent of the consideration of sex, gender, class etc. is composed of five elements (Paṇcakkhandhā): namely rupa skandha, samjṇa skandha, vedanā skandha, saṁskāra skandha and vijṇanā skandha. On this basis, Buddhism has advocated the equality between man and women and thus has transcended the gender difference. It treats man and woman equally. Buddhism reflected in the Buddhist scriptures that there is a biological difference between women and men, but they have similar intellectual, mental as well as spiritual capabilities.
The development of a large Schools Management According the King’s Philosophy Model
Authors: Et al. Phrapalad Somchai Payogo 
Published: February 2021

This research aims to 1) study the elements of the development of a large school management model in accordance with the king's science, 2) develop a large school management model based on the monarchy, and 3) assess the suitability and appropriateness of the monarchy. The possibility of developing a large school management model according to the king's science By using a mixed method, a research was carried out in 4 steps: 1) study the elements of the development of a large school management model; 2) to develop a large school management model using the royal science Using the Delphi Technique and Focus Group Discussion, 3) analyzed the key elements through factor analysis and 4) assessing the feasibility and feasibility of the management model development. Manage a large school according to the king's science. From 30 school administrators, the statistics used for data analysis were percentage, range, quartile, mean, standard deviation, and component analysis. The research results were found as follows: 1) development of a large school management model according to the king's science is the management of the work with the middle line which consists of the philosophy of sufficiency economy and the principle of work of the king to achieve sustainable school development. 2) Develop a large school management model according to the king's science. There are 5 main components as follows: Sufficiency Economy Philosophy Understanding In terms of accessibility, development, and of the King's work principles.3) The degree of suitability and feasibility of the development of a large school management model according to the monarchy. Overall and each item are very good.
Ritual of ancestor Sacrifice and Social Function in the Veda and Thai People
Authors: Et al. Thanakorn Choosukhserm 
Published: February 2021

The objectives of this academic article aimed to 1) to study the ritual of ancestor sacrifice in the Veda and Thai society and 2) to study the theories of folklore influenced toward the way of life of Vedic people and Thai society. The results indicated that the ritual or ceremony is a kind of activity and function in all human beings’ society which related to and arranged by a doctrine, religion, or belief of tradition and culture for alchemy, supernaturalism or good fortune, etc. Ritual of ancestor sacrifice is a kind of belief in the Vedic period which is worshiped, performed, and continued from that time until the present. Vedic people believed in their ancestors’ spirits and so did Thai people. Both people in the two nations believed that the ancestors’ spirits could punish their relatives who had bad behaviors but help those who had good behaviors. Both nations have still believed that ancestors’ spirits can provide them goodness and badness so they usually have to perform the sacrifices to the ancestors. Then, the ritual of ancestor sacrifice has become the deep belief of two cultures, unify, and create people to be a unique and happy society under their belief.
An Approach to the Development and the Promotion of Secondary Tourism Destinations: A Case Study of BuengKan – A Potential Tourism Destination in Northeastern Thailand
Authors: Techakana Jusana 
Published: February 2021

The Government of Thailand has announced a policy to develop and promote 55 provinces of Thailand to become secondary tourism destinations, BuengKan is a new-born province in the Northern part of Thailand, which is not a popular tourism region compared to the Northern and the Southern regions of the country. Nonetheless, BuengKan has a high potential to become a popular secondary tourism destination because it has a lot of tourism resources to develop various types of tourism with many modes of accessibility. In order to formulate a strategy to develop and promote BuengKan to become a popular secondary tourism destination, guidelines and recommendations from all stakeholders, including the public sector, the private sector, the community sector, and the academic sector need to be gathered. A qualitative research was conducted by employing in-depth interviews with public officers, local politicians, chamber of commerce members, private entrepreneurs in tourism industry, prominent figures of community members, and scholars in the fields of tourism, marketing, and marketing communications. Their answers from the in-depth interviews have been analyzed and organized to formulate development and promotion strategies to make BuengKan a popular secondary tourism destination of Thailand
Randomised, double-blind comparison of a fixed co-formulation of intra-articular polynucleotides and hyaluronic acid versus hyaluronic acid alone in the treatment of knee osteoarthritis: two-year follow-up
Authors: Stagni Cesare , Rocchi Martina , Mazzotta Alessandro , Piccolo Nicolandrea Del , Rani Nicola , Govoni Marco , Vivarelli Leonardo , Veronesi Francesca , Fini Michela , Dallari Dante 
Published: February 2021

Abstract
Background: A first-year interim analysis of this two-year study suggested that intra-articular injections of highly purified, natural-origin polynucleotides and hyaluronic acid (HA) as a fixed combination (PNHA) might improve knee function and joint pain more effectively than HA alone in patients with knee osteoarthritis (OA). Purpose of the second-year analysis herein described was verifying whether the first-year interim outcomes persist over the whole two-year period.
Methods: Randomised, double-blind, HA-controlled clinical trial in 100 knee OA patients (98 randomised, 69 completing the study) in a high-specialisation tertiary care setting. The hypothesised difference of efficacy between PNHA and HA for the original sample size estimate is 20%. Treatment cycle: 3 weekly intra-articular knee injections of either PNHA or HA. Evaluations: Western Ontario and McMaster Universities (WOMAC) score and Knee Society Score (KSS) as, respectively, primary and secondary endpoints, evaluated at baseline and after 2, 6, 12, and 24 months; synovial fluid levels of proinflammatory mediators (biochemical and immunoenzymatic assays at baseline and the end of the treatment cycle). Adverse effects investigated at each control visit. Statistical analysis: Kruskal-Wallis test for independent samples (nonparametric one-way analysis of variance) after correction of means for age, Body Mass Index and Kellgren-Lawrence grade. If significant, pairwise post-hoc Sidak multiple comparisons.
Results: KSS total score and KSS pain item: significant improvement in both groups, with significantly more pain improvement in patients treated with PNHA (2-point reduction) than HA (1-point reduction). Both groups experienced significant long-term reductions in WOMAC total scores: significantly stronger in PNHA-treated patients after 24 months with a steady difference of 16% favouring PNHA in WOMAC pain subscore. No clinically significant adverse events in either group.
Conclusions: The outcomes of the 2-year study confirmed that a short cycle of intra-articular treatment (3 weekly double-blind injections) with polynucleotides (long-acting viscosupplementation properties, pro-trophic activity on chondrocytes, pain-relieving properties) in fixed combination with high molecular weight hyaluronic acid is more effective in improving knee function and pain in knee OA patients than HA alone. PNHA may be elective for viscosupplementation in knee OA patients with fastidious and resistant pain, signs of inflammation or worsening disease.
A CTLA-4 Blocking Strategy Based on Nanobaby in Dendritic Cell-stimulated Cytokine-induced Killer Cells Enhances Their Anti-tumor Effects
Authors: Wang Wu , Zhong Kai , Wang Xi , Yang Wenli , He Na , Li Xuexia , Pang Yanyang , Liu Aiqun , Lu Xiaoli 
Published: February 2021

Abstract
Background: Cytokine-induced killer cells which were induced with tumor antigen-pulsed dendritic cells (DC-CIK) immunotherapy is a promising strategy for the treatment of malignant tumors. However, the efficacy was restricted by the immunosuppression of tumor microenvironment mediated by the cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) pathway. We, therefore, screened a nanobody which is targeted for CTLA-4 (Nb36), and blocked the CTLA-4 signaling with Nb36 to overcome the negative co-stimulation of effector T cells. Methods: Peripheral blood mononuclear cells (PBMCs) were collected from healthy donors and used to induce CIK cells in vitro, then co-cultured with DC cells that have received tumor antigens. We tested whether blocking CTLA-4 signaling with Nb36 could promote DC-CIK cells proliferation, pro-inflammatory cytokine production and cytotoxicity in vitro. In vivo experiments, The NOD/SCID mice were injected subcutaneously with HepG2 cells to induce solid tumor. We observe whether this therapy can more effectively inhibit tumor growth in mice. Results: After being stimulated with Nb36, DC-CIK cells presented enhanced proliferation and production of IFN-γ in vitro, thereby strengthening the killing effect on tumor cells. For in vivo experiments, Nb36-treated DC-CIK cells significantly inhibited the growth of subcutaneously transplanted tumors of liver cancer, reduced tumor weight and prolonged the survival of tumor-bearing NOD/SCID mice. Conclusions: These findings demonstrated that in response to CTLA-4 specific nanobody stimulation, DC-CIK cells exhibited superior anti-tumor efficacy. Our findings suggested that DC-CIK cells + Nb36 has potential to treat malignant tumors through in vivo adoptive therapy.
Exploring the mechanism of Bushenhuoxue formula acting on postmenopausal osteoporosis via network pharmacology and experimental validation
Authors: Ke Chunhai , Chen Yizhou , Wang Yi , He Guonong , Lou Hongkai , Mao Dandan , Jin Hongting , Wu Chengliang , Fang Liang , Xia Chenjie 
Published: February 2021

Abstract
Background: Bushenhuoxue (BSHX) formula, a ten-compound herbal decoction, has been used to treat postmenopausal osteoporosis (PMOP) in China for decades. Our previous study also revealed the anti-PMOP effects of BSHX formula in ovariectomized (OVX) mice. However, its pharmacological mechanisms remain unknown. Methods: Network pharmacology followed by animal experiments was used to explore the action mechanism of BSHX formula. Firstly, we obtained the chemical compounds and potential targets of BSHX formula using TCMSP and TCMID databases. Simultaneously, GeneCards and DisGeNET databases were used to determine the targets in PMOP. Based on their overlapping genes between BSHX formula and PMOP, a protein-protein interaction (PPI) network was constructed for screening hub-targets. GO and KEGG enrichment analyses were further performed to identify the critical biological processes and signaling pathways. In vivo experimental study, an OVX mouse model was established to determine the anti-PMOP effects of BSHX formula via Micro-CT assay and ABH staining. The expressions of β-catenin, alkaline phosphatase (ALP), vascular endothelial growth factor (VEGF) and CD31 were detected by immunohistochemistry.Results: A total of 218 active ingredients and 274 related targets were identified in BSHX formula. After matching with 292 therapeutic targets of PMOP, 64 overlapping genes were obtained and further used to build a PPI network in which CTNNB1 and VEGFA played a central role. GO and KEGG enrichment analyses indicated that the anti-PMOP effects of BSHX formula were mainly associated with cell proliferation, angiogenesis and their regulated pathways including β-catenin signaling and VEGF signaling. In mouse experiments, we revealed that bone mass and blood vessels in the OVX mice were significantly enhanced after treated with BSHX formula for 8 weeks. Moreover, down-regulations of β-catenin, ALP, VEGF and CD31 caused by OVX surgery were significantly restored by BSHX formula.Conclusions: Through network pharmacology and an experimental validation, we have revealed that BSHX formula exerts anti-PMOP effects mainly through promoting β-catenin-mediated osteogenesis and VEGF-mediated angiogenesis. BSHX formula can be considered as a new option for the treatment of PMOP.
DDIT4 is involved in PPAR-γ mediated Fatty Acid intake to promote the Proliferation of Pancreatic Cancer
Authors: Ding Fadian , Gao Feng , Lian Wei , Huang Shirong , Wang Hanjun , Zhang Shuyu , Lv Xiaoting , Liu Qicai , Chen Youting 
Published: February 2021

Abstract
Background: DDIT4 is a tumor metabolism-related protein which is involved in the proliferation and survival of various tumors. However, the function of DDIT4 in the pancreatic cancer is still unknown.Methods: We collected clinical samples of pancreatic cancer and established animal models of pancreatic cancer and DDIT4-HET animal models. We examined the expression of DDIT4 in pancreatic cancer tissues by IHC and WB and the degree of fat infiltration in the pancreas by HE staining and oil-red O staining. What’s more, the Western blot and immunohistochemical methods were applied to test the expression levels of PPAR-γ and CD36. Meanwhile, the apoptosis and proliferation levels were also examined in DDIT4-HET pancreatic cancer model.Results:The expression of DDIT4 is decreased in pancreatic cancer and DDIT4 regulates the development of pancreatic cancer by participating in fat infiltration. The degree of fat infiltration in DDIT4-HET pancreatic cancer tumors is higher than that in wild-type pancreatic cancer tumors. Through transgenic animal models, we found that DDIT4 regulates lipid metabolism in pancreatic cancer by regulating PPAR-γ and its downstream proteins CD36 and ATGL, and DDIT4-mediated lipid metabolism abnormality is involved in the proliferation and apoptosis of pancreatic cancer.Conclusion: The low expression of DDIT4 promotes the proliferation and survival by regulating lipid metabolism in pancreatic cancer cells.
The nodule-specific multifunctional channel NOD26 of Medicago truncatula is crucial for nitrogen-fixing symbiosis
Authors: Frare Romina , Gómez Cristina , López-Fernández María Paula , Alleva Karina , Nikel Pablo , Ayub Nicolás , Soto Gabriela 
Published: February 2021

Abstract
The multifunctional channel NOD26, identified and extensively studied (both biochemically and biophysically) in soybean, is a major protein component of the symbiosome membrane. The water and ammonia transport activities of NOD26 are thought to be important for nodule development, osmotic balance, and ammonia efflux from the symbiosome. However, the widely accepted relevance of NOD26 in nitrogen-fixing symbiosis has never been explored in planta. Recently, we have reported the emergence of NOD26 in the nitrogen-fixing clade of angiosperms via tandem duplication. Here, we characterized the two copies of NOD26 from Medicago truncatula (Medtr8g087710 and Medtr8g087720) in their transport abilities, and at gene expression and genetic levels. Similar to their homologous soybean gene, MtNOD26 genes encode water and ammonia transport activities in heterologous expression systems. By using multiple transcriptional studies (RT-qPCR, transcriptional fusion and RNA-Seq analyses), we found that the expression of MtNOD26 copies is restricted to the nodule and gradually increases from the bacteria-free meristematic region to the nitrogen-fixation zone. Under nitrogen-limiting soil conditions, the homozygous insertional mutant lines of these two MtNOD26 genes had the same aberrant nodulation phenotype and chlorosis. Similar to uninoculated wild-type plants, inoculated mutants were unable to grow in minimal medium without a nitrogen source. Collectively, our findings suggest functional equivalence between MtNOD26 copies and underline a crucial role of NOD26 in symbiotic nitrogen fixation.
Investigation on Seismic Behaviour of Masonry Infilled Self-Centring-Beam Moment-Frames using New Infill Material Model
Authors: Huang Xiaogang , Zhou Zhen , wang yuhang 
Published: February 2021

Abstract
This paper conducted experimental and numerical investigations on seismic behaviour of masonry infilled self-centring-beam moment-frames (SCB-MFs). First, an efficient hysteretic material model was proposed for use with the equivalent strut modelling approach of infill walls. This model was defined by backbone parameters and hysteretic parameters and implemented in the OpenSees platform to facilitate its application. Then, an approximately half-scale test of infilled SCB-MFs was carried out. The test observations and load-carrying capacities of masonry walls in the specimen were reported and analysed. The experimental hysteresis was reproduced by the numerical model using the proposed infill material. Finally, structural analyses were conducted for 3-, 6-, 9-, and 12-storey infilled SCB-MFs based on the calibrated computational model. Comparisons of the hysteretic behaviours obtained by the simulation with experimental results showed that the proposed infill material could capture the strength, stiffness, and energy dissipation during reloading, along with the residual drift during unloading. The nonlinear dynamic analyses also validated the feasibility of using the proposed model to simulate the dynamic responses of infilled SCB-MFs.