bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physico-chemical properties and toxicological effects on plant and algal models of carbon nanosheets from a nettle fibre clone
Authors: Shah Syed Shaheen , Qasem Mohammed Ameen Ahmed , Berni Roberto , Del Casino Cecilia , Cai Giampiero , Contal Servane , Ahmad Irshad , Siddiqui Khawar Sohail , Gatti Edoardo , Predieri Stefano , Hausman Jean-Francois , Cambier Sébastien , Guerriero Gea , Aziz Md.Abdul 
Published: March 2021

AbstractCarbon nanosheets are two-dimensional nanostructured materials that have applications as energy storage devices, electrochemical sensors, sample supports, filtration membranes, thanks to their high porosity and surface area. Here, for the first time, carbon nanosheets have been prepared from the stems and leaves of a nettle fibre clone, by using a cheap and straight-forward procedure that can be easily scaled up. The nanomaterial shows interesting physical parameters, namely interconnectivity of pores, graphitization, surface area and pore width. These characteristics are similar to those described for the nanomaterials obtained from other fibre crops. However, the advantage of nettle over other plants is its fast growth and easy propagation of homogeneous material using stem cuttings. This last aspect guarantees homogeneity of the starting raw material, a feature that is sought-after to get a nanomaterial with homogeneous and reproducible properties. To evaluate the potential toxic effects if released in the environment, an assessment of the impact on plant reproduction performance and microalgal growth has been carried out by using tobacco pollen cells and the green microalgaPseudokirchneriella subcapitata. No inhibitory effects on pollen germination are recorded, while algal growth inhibition is observed at higher concentrations of leaf carbon nanosheets with lower graphitization degree.
Preliminary functional analysis of the subgingival microbiota of cats with periodontitis and feline chronic gingivostomatitis
Authors: Rodrigues Marjory Xavier , Fiani Nadine , Bicalho Rodrigo Carvalho , Peralta Santiago 
Published: March 2021

AbstractThe subgingival microbial communities of domestic cats remain incompletely characterized and it is unknown whether their functional profiles are associated with disease. In this study, we used a shotgun metagenomic approach to explore the functional potential of subgingival microbial communities in client-owned cats, comparing findings between periodontally healthy cats and cats with naturally occurring chronic periodontitis, aggressive periodontitis, and feline chronic gingivostomatitis. Subgingival samples were subjected to shotgun sequencing and the metagenomic datasets were analyzed using the MG-RAST metagenomic analysis server and STAMP v2.1.3 (Statistical Analysis of Metagenomic Profiles) software. The microbial composition was also described to better understand the predicted features of the communities. The Respiration category in the level 1 Subsystems database varied significantly among groups. In this category, the abundance of V-Type ATP-synthase and Biogenesis of cytochrome c oxidases were significantly enriched in the diseased and in the healthy groups, respectively. Both features have been previously described in periodontal studies in people and are in consonance with the microbial composition of feline subgingival sites. In addition, the narH (nitrate reductase) gene frequency, identified using the KEGG Orthology database, was significantly increased in the healthy group. The results of this study provide preliminary functional insights of the microbial communities associated with periodontitis in domestic cats and suggest that the ATP-synthase and nitrate-nitrite-NO pathways may represent appropriate targets for the treatment of this common disease.
Estimation of hygroscopic growth properties of source-related sub-micrometre particle types in a mixed urban aerosol
Authors: Vu Tuan V. , Shi Zongbo , Harrison Roy M. 
Published: March 2021

AbstractKnowledge of hygroscopic properties is essential to prediction of the role of aerosol in cloud formation and lung deposition. Our objective was to introduce a new approach to classify and predict the hygroscopic growth factors (Gfs) of specific atmospheric sub-micrometre particle types in a mixed aerosol based on measurements of the ensemble hygroscopic growth factors and particle number size distribution (PNSD). Based on a non-linear regression model between aerosol source contributions from PMF applied to the PNSD data set and the measured Gf values (at 90% relative humidity) of ambient aerosols, the estimated mean Gf values for secondary inorganic, mixed secondary, nucleation, urban background, fresh, and aged traffic-generated particle classes at a diameter of 110 nm were found to be 1.51, 1.34, 1.12, 1.33, 1.09 and 1.10, respectively. It is found possible to impute (fill) missing HTDMA data sets using a Random Forest regression on PNSD and meteorological conditions.
Carrier photodynamics in 2D perovskites with solution-processed silver and graphene contacts for bendable optoelectronics
Authors: Hossain Ridwan F. , Min Misook , Ma Liang-Chieh , Sakri Shambhavi R. , Kaul Anupama B. 
Published: March 2021

AbstractSilver (Ag) and graphene (Gr) inks have been engineered to serve as efficient electrical contacts for solution-processed two-dimensional (2D) organo-halide (CH3(CH2)3NH3)2(CH3NH3)n−1PbnI3n+1 (n = 4) layered perovskites, where all inkjet-printed heterostructure photodetectors (PDs) were fabricated on polyimide (PI) substrates. To date, limited studies exist that compare multiple contacts to enable high-performance engineered contacts to 2D perovskites. Moreover, of these few reports, such studies have examined contacts deposited using vapor-based techniques that are time-consuming and require expensive, specialized deposition equipment. In this work, we report on the inkjet printed, direct contact study of solution-processed, 2D perovskite-based PDs formed on flexible PI substrates. Solution processing offers a cost-effective, expedient route for inkjet printing Gr and Ag using a dispersion chemistry developed in this work that is compatible with the underlying 2D perovskite layer to construct the PDs. The wavelength λ-dependent photocurrent Ip peaked at λ ~ 630 nm for both PDs, consistent with the bandgap Eg ~ 1.96 eV for our semiconducting 2D perovskite absorber layer. The external quantum efficiency was determined to be 103% for Ag-perovskite PDs, where strain-dependent bending tests were also conducted to reveal the opto-mechanical modulation of the photocurrent in our devices.
Distribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion disease
Authors: Cheng Lesley , Quek Camelia , Li Xia , Bellingham Shayne A. , Ellett Laura J. , Shambrook Mitch , Zafar Saima , Zerr Inga , Lawson Victoria A. , Hill Andrew F. 
Published: March 2021

AbstractPrion diseases are distinguished by long pre-clinical incubation periods during which prions actively propagate in the brain and cause neurodegeneration. In the pre-clinical stage, we hypothesize that upon prion infection, transcriptional changes occur that can lead to early neurodegeneration. A longitudinal analysis of miRNAs in pre-clinical and clinical forms of murine prion disease demonstrated dynamic expression changes during disease progression in the affected thalamus region and serum. Serum samples at each timepoint were collected whereby extracellular vesicles (EVs) were isolated and used to identify blood-based biomarkers reflective of pathology in the brain. Differentially expressed EV miRNAs were validated in human clinical samples from patients with human sporadic Creutzfeldt-Jakob disease (sCJD), with the molecular subtype at codon 129 either methionine-methionine (MM, n = 14) or valine-valine (VV, n = 12) compared to controls (n = 20). EV miRNA biomarkers associated with prion infection predicted sCJD with an AUC of 0.800 (85% sensitivity and 66.7% specificity) in a second independent validation cohort (n = 26) of sCJD and control patients with MM or VV subtype. This study discovered clinically relevant miRNAs that benefit diagnostic development to detect prion-related diseases and therapeutic development to inhibit prion infectivity.
Efficacy and long-term safety of CRISPR/Cas9 genome editing in the SOD1-linked mouse models of ALS
Authors: Deng Han-Xiang , Zhai Hong , Shi Yong , Liu Guoxiang , Lowry Jessica , Liu Bin , Ryan Éanna B. , Yan Jianhua , Yang Yi , Zhang Nigel , Yang Zhihua , Liu Erdong , Ma Yongchao C. , Siddique Teepu 
Published: March 2021

AbstractCRISPR/Cas9-mediated genome editing provides potential for therapeutic development. Efficacy and long-term safety represent major concerns that remain to be adequately addressed in preclinical studies. Here we show that CRISPR/Cas9-mediated genome editing in two distinct SOD1-amyotrophic lateral sclerosis (ALS) transgenic mouse models prevented the development of ALS-like disease and pathology. The disease-linked transgene was effectively edited, with rare off-target editing events. We observed frequent large DNA deletions, ranging from a few hundred to several thousand base pairs. We determined that these large deletions were mediated by proximate identical sequences in Alu elements. No evidence of other diseases was observed beyond 2 years of age in these genome edited mice. Our data provide preclinical evidence of the efficacy and long-term safety of the CRISPR/Cas9 therapeutic approach. Moreover, the molecular mechanism of proximate identical sequences-mediated recombination provides mechanistic information to optimize therapeutic targeting design, and to avoid or minimize unintended and potentially deleterious recombination events.
A cascade double 1,4-addition/intramolecular annulation strategy for expeditious assembly of unsymmetrical dibenzofurans
Authors: He Xinwei , Li Ruxue , Choy Pui Ying , Xie Mengqing , Duan Jiahui , Tang Qiang , Shang Yongjia , Kwong Fuk Yee 
Published: March 2021

AbstractExisting synthetic routes for accessing dibenzofuran core have intrinsic regioselectivity, limiting the substitution patterns available in heteropolycyclic arene products. Here we report a double 1,4-conjugate addition/intramolecular annulation cascade reaction between propargylamines and two equivalents of imidazolium methylides that allows efficient access of structurally versatile dibenzofurans. This transition metal-free protocol proceeds smoothly under bench-top air atmosphere and offers easy manipulation of substituents on the dibenzofuran core, and also provides good-to-excellent product yields with good functional group tolerance, particularly the –Br and –Cl groups which are often incompatible with existing metal-catalyzed C–C and/or C–O bond ring-forming processes. It is worth noting that ladder-type π-systems with all-arene quarternary carbon structure can be straightforwardly generated upon simple late-stage functionalization.
A gateway for ion transport on gas bubbles pinned onto solids
Authors: Haziri Veton , Nha Tu Pham Tran , Berisha Avni , Boily Jean-François 
Published: March 2021

AbstractGas bubbles grown on solids are more than simple vehicles for gas transport. They are charged particles with surfaces populated with exchangeable ions. We here unveil a gateway for alkali metal ion transport between oxygen bubbles and semi-conducting (iron oxide) and conducting (gold) surfaces. This gateway was identified by electrochemical impedance spectroscopy using an ultramicroelectrode in direct contact with bubbles pinned onto these solid surfaces. We show that this gateway is naturally present at open circuit potentials, and that negative electric potentials applied through the solid enhance ion transport. In contrast, positive potentials or contact with an insulator (polytetrafluoroethylene) attenuates transport. We propose that this gateway is generated by overlapping electric double layers of bubbles and surfaces of contrasting (electro)chemical potentials. Knowledge of this ion transfer phenomenon is essential for understanding electric shielding and reaction overpotential caused by bubbles on catalysts. This has especially important ramifications for predicting processes including mineral flotation, microfluidics, pore water geochemistry, and fuel cell technology.
Light-wave control of correlated materials using quantum magnetism during time-periodic modulation of coherent transport
Authors: Lingos Panagiotis C. , Kapetanakis Myron D. , Wang Jigang , Perakis Ilias E. 
Published: March 2021

AbstractLight–wave quantum electronics utilizes the oscillating carrier wave to control electronic properties with intense laser pulses. Without direct light–spin interactions, however, magnetic properties can only be indirectly affected by the light electric field, mostly at later times. A grand challenge is how to establish a universal principle for quantum control of charge and spin fluctuations, which can allow for faster-than-THz clock rates. Using quantum kinetic equations for the density matrix describing non–equilibrium states of Hubbard quasiparticles, here we show that time–periodic modulation of electronic hopping during few cycles of carrier–wave oscillations can dynamically steer an antiferromagnetic insulating state into a metalic state with transient magnetization. While nonlinearities associated with quasi-stationary Floquet states have been achieved before, magneto–electronics based on quasiparticle acceleration by time–periodic multi–cycle fields and quantum femtosecond/attosecond magnetism via strongly–coupled charge–spin quantum excitations represents an alternative way of controlling magnetic moments in sync with quantum transport.
Oxidative cross-dehydrogenative coupling between iodoarenes and acylanilides for C–N bond formation under metal-free conditions
Authors: Yang Peng , Wang Xia , Wang Liang , He Jiahua , Zhang Qian , Li Dong 
Published: March 2021

A metal-free oxidative cross-dehydrogenative coupling between iodoarenes and acylanilides was developed. It gave highly para-selectivie C–N coupling products with the retention of iodine atom which enables further transformations.
Prediction of prognosis of patients with lung cancer in combination with the immune score
Authors: Han Ke , Qian Kun , Zhao Teng , Liu Xing Sheng , Zhang Yi 
Published: March 2021

Abstract
Purpose: The host’s immune response to malignant tumor is fundamental to tumorigenesis and tumor development. The immune score is currently used to assess prognosis and to guide immunotherapy; however, its association with lung cancer prognosis is not clear.
Methods: Clinical features and immune score data of lung cancer patients from The Cancer Genome Atlas were obtained to build a clinical prognosis nomogram. The model’s accuracy was verified by calibration curves.
Results: In total, 1005 patients with lung cancer were included. Patients were divided into three groups according to low, medium, and high immune scores. Compared with patients in the low immune score group, the disease-free survival (DFS) of patients in medium and high immune score groups was significantly longer; the hazard ratio (HR) and 95% confidence interval (95% CI) were 0.77 [0.60–0.99] and 0.74 [0.60–0.91], respectively. The overall survival (OS) of patients in the medium and high immune score groups was significantly longer than in the low immune score group; the HR and 95% CI were 0.74 [0.57–0.96] and 0.69 [0.55–0.88], respectively. A clinical prediction model was established to predict the survival prognosis. As verified by calibration curves, the model showed good predictive ability, especially for predicting 3-/5-year DFS and OS.
Conclusion: Patients with lung cancer with medium and high immune scores had longer DFS and OS than those in low immune score group. Patient prognosis can be effectively predicted by the clinical prediction model combining clinical features and immune score and was consistent with actual clinical outcomes.
Photoredox-Mediated Asymmetric Cross-Dehydrogenative Coupling of Enones and Tertiary Amines by Chiral Primary Amine Catalysis
Authors: Luo Sanzhong , Jia Zongbin , Yang Qi 
Published: March 2021

AbstractA catalytic asymmetric dehydrogenative cross-coupling reaction between enones and tertiary amines enabled by synergistic photoredox and chiral primary amine catalysis is reported. The reaction was proposed to proceed via the interception of iminium ion intermediate, in situ generated from photoredox oxidation, by dienamine at α-position, followed by isomerization, leading to aza-Morita–Baylis–Hillman-type products with good diastereo- and enantioselectivity.
In the Pursuit of (Ald)Imine Surrogates for the Direct Asymmetric Synthesis of Non-Proteinogenic α-Amino Acids
Authors: Roche Stéphane P. 
Published: March 2021

AbstractNature remarkably employs posttranslational modifications of the 20 canonical α-amino acids to devise a far larger structural, conformational, and functional diversity found in non-proteinogenic amino acids (NPAAs), which ultimately translates into a plethora of complex biological functions. Synthetic chemists are continuously trying to reproduce and even extrapolate the repertoire of NPAA building blocks to build structural diversity into bioactive molecules and materials. The direct asymmetric functionalization of α-imino esters represents one of the most robust and attractive routes to NPAAs. This review summarizes the most prominent examples of bench-stable (ald)imine surrogates exploited for the synthesis of NPAAs, including our most recent results in the nucleophilic substitution of α-haloglycines and other α-halo­aminals. A synopsis of kinetic studies, reaction optimizations, and enantio­selective catalytic methods is also presented.1	Introduction2	Asymmetric Synthesis of Tertiary α-Substituted NPAAs2.1	From N,O-Acetals (α-Hydroxy/Alkyloxy/Acetoxyglycines)2.2	From α-Amido Sulfones2.3	From α-Haloglycine Esters2.4	From N,O-Bis(Boc) Hydroxyglycine3	Asymmetric Synthesis of Acyclic Quaternary α,α-Disubstituted	NPAAs4	Concluding Remarks
A Convenient Protecting Group for Uridine Ureido Nitrogen: (4,4′-Bisfluorophenyl)methoxymethyl Group
Authors: Kurosu Michio , Mitachi Katsuhiko , Mingle David 
Published: March 2021

Abstract(4,4′-Bisfluorophenyl)methoxymethyl (BFPM) group of uridine ureido nitrogen shows good relative stability in a variety of chemical transformation reactions for uridine. The BFPM group can be cleaved by 2% of TFA in CH2Cl2 without affecting the Boc group.
Cobalt-Catalyzed Isomerization of Alkenes
Authors: Findlater Michael , Zhang Sheng 
Published: March 2021

AbstractCatalytic isomerization of alkenes is a highly atom-economical approach to upgrade from lower- to higher-value alkenes. Consequently, tremendous attention has been devoted to the development of this transformation, approaches which exploit cobalt catalysis are particularly attractive. This short review focuses on the cobalt-catalyzed alkene isomerization, including positional isomerization, geometric isomerization, and cycloisomerization. Three main types of reaction mechanism have been discussed to help the reader to better understand and make meaningful comparison between the different transformations.1	Introduction2	Positional Isomerization3	Geometric Isomerization4	Cycloisomerization5	Conclusion and Outlook
Fratura exposta do colo do fêmur em adulto: Relato de caso e solução cirúrgica
Authors: Campos Roni Serra , Correia Marcos Alves , Menezes Ricardo , Duarte Maria Eugenia Leite , Guimarães João Antonio Matheus 
Published: March 2021

ResumoA fratura intracapsular do fêmur proximal é uma lesão frequente no paciente idoso, e em geral está associada a trauma de baixa energia e redução da massa óssea. No jovem, esta lesão é pouco frequente, decorre de trauma de alta energia, e resulta em dano das partes moles adjacentes. Contudo, o relato de fratura intracapsular do fêmur proximal com exposição óssea por trauma indireto é raro na literatura ortopédica. Neste relato, esta lesão foi diagnosticada em um homem de 35 anos, vítima de acidente automobilístico. Mediante um mecanismo semelhante ao da luxação posterior do quadril, o segmento proximal do fêmur determinou exposição óssea através da região glútea. Foram descritos o tratamento inicial e os tratamentos subsequentes até a solução definitiva por artroplastia total do quadril associada a transposição muscular para reconstrução do mecanismo abdutor do quadril. Após 10 meses de seguimento, o paciente apresentava boa recuperação funcional, com retorno gradual da força abdutora, Harris Hip Score de 91 pontos, com estudo radiográfico revelando prótese total cimentada bem posicionada. A estratégia terapêutica utilizada neste paciente (artroplastia total do quadril com transferência muscular para a reconstrução da musculatura abdutora) foi uma solução eficiente para tratar a fratura intracapsular do fêmur proximal com exposição óssea.
Spontaneous Perinephric Urinoma Secondary to Drug Induced Acute Interstitial Nephritis: A Case Report
Authors: Varatharajaperumal Rajesh Kumar , Renganathan Rupa , Mangalakumar V , Rajasekaran Sriman , Arunachalam Venkatesh Kasi 
Published: March 2021

AbstractUrinoma is defined as the extravasation of urine from any part of the urinary collecting system, which causes lipolysis of the surrounding fat, resulting in an encapsulated collection. The most common cause of urinoma is the direct obstruction of the urinary system. The other etiologies include trauma and postinstrumentation/surgery. Parenchymal cause for spontaneous urinoma is exceedingly rare. We present a case of a 30-year-old gentleman who presented with lower abdominal pain and was treated with a Diclofenac injection. The pain got better temporarily, but he presented again with right loin pain after 3 days. His computed tomography scan images revealed bilateral perinephric urinoma. As there was significant deterioration of renal function, he underwent a renal biopsy. The histopathology was reported as acute interstitial nephritis (AIN). Drug-induced AIN is very rarely presented with acute loin or abdominal pain due to spontaneous perinephric urinoma, as it was seen in our case.