bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype
Authors: Watanabe Hiraku , Kojima Sho , Nagasaka Kazuaki , Ohno Ken , Sakurai Noriko , Kodama Naoki , Otsuru Naofumi , Onishi Hideaki 
Published: September 2021

Abstract
Although brain gray matter (GM) plastically changes during short-term training, it is still unclear whether brain structures are stable for short periods (several months). Therefore, this study aimed to re-test the short-term variability of GM volumes and to clarify the effect of factors (gender and BDNF-genotype) expected to contribute to such variability. The subjects comprised 41 young healthy adults. T1-weighted images were acquired twice with an interval of approximately 4 months using a 3 T-MRI scanner. Voxel-based morphometry (VBM) was used to calculate GM volumes in 47 regions. The intraclass correlation coefficient (ICC) and Test–retest variability (%TRV) were used as indices of variability. As a result, the ICCs in 43 regions were excellent (ICC &gt; 0.90) and those in 3 regions were good (ICC &gt; 0.80), whereas the ICC in the thalamus was moderate (ICC = 0.694). Women had a higher %TRV than men in 5 regions, and %TRV of the Val66Val group was higher than that of the Met carrier group in 2 regions. Moreover, the Female-Val66Val group had a higher %TRV than the Male-Met carrier group in 3 regions. These results indicate that although the short-term variability of GM volumes is small, it is affected by within-subject factors.
Determination of the Chemical Stability of Dapagliflozin by LC/DAD and MS/MS Methods
Authors: Chan-Jiang Emily , Godoy Ricardo , Mennickent Sigrid , Vergara Carola , de Diego Marta 
Published: September 2021

Abstract
A simple and fast stability-indicating liquid chromatographic method with diode array detection (DAD) was developed and validated for the determination of dapagliflozin (DAPA) in bulk and tablets, in the presence of its major degradation products (DP). The drug was subjected to hydrolytic, oxidative, photolytic, thermal and humidity/thermal stress conditions, showing significant degradation under humidity/thermal with the formation of two DP, which were preliminarily identified by liquid chromatography with diode array detector coupled with electrospray ionization–tandem mass spectrometry (HPLC-DAD-ESI-MS/MS). Chromatographic separation of dapagliflozin and its DP was achieved with a core-shell RP-18 column, using acetonitrile and water as mobile phase in isocratic elution mode. The described method was linear over a range of 50–150 μg/mL. For precision, the relative standard deviation (RSD) was &lt;1.3%, the recovery was 99.64–100.11%, and the assay demonstrated adequate selectivity. The degradation kinetics of dapagliflozin was evaluated corresponding to first-order under thermal and humidity/thermal stress conditions. Dapagliflozin was well resolved from its drug products showing the power of stability-indicating of the method. The results showed that the proposed method was found to be suitable for routine analysis, quantitative determination and the stability study of dapagliflozin in pharmaceutical samples.
Vaccine Impact and Effectiveness of Meningococcal Serogroup ACWY Conjugate Vaccine Implementation in the Netherlands: A Nationwide Surveillance Study
Authors: Ohm Milou , Hahné Susan J M , van der Ende Arie , Sanders Elisabeth A M , Berbers Guy A M , Ruijs Wilhelmina L M , van Sorge Nina M , de Melker Hester E , Knol Mirjam J 
Published: September 2021

Abstract

Background
In response to the recent serogroup W invasive meningococcal disease (IMD-W) epidemic in the Netherlands, meningococcal serogroup C (MenC) conjugate vaccination for children aged 14 months was replaced with a MenACWY conjugate vaccination, and a mass campaign targeting individuals aged 14–18 years was executed. We investigated the impact of MenACWY vaccination implementation in 2018–2020 on incidence rates and estimated vaccine effectiveness (VE).

Methods
We extracted IMD cases diagnosed between July 2014 and December 2020 from the national surveillance system. We calculated age group–specific incidence rate ratios by comparing incidence rates before (July 2017–March 2018) and after (July 2019–March 2020) MenACWY vaccination implementation. We estimated VE in vaccine-eligible cases using the screening method.

Results
Overall, the IMD-W incidence rate declined by 61% (95% confidence interval [CI], 40 to 74). It declined by 82% (95% CI, 18 to 96) in the vaccine-eligible age group (individuals aged 15–36 months and 14–18 years) and by 57% (95% CI, 34 to 72) in vaccine-noneligible age groups. VE was 92% (95% CI, –20 to 99.5) in vaccine-eligible toddlers (aged 15–36 months). No IMD-W cases were reported in vaccine-eligible teenagers after the campaign.

Conclusions
The MenACWY vaccination program was effective in preventing IMD-W in the target population. The IMD-W incidence reduction in vaccine-noneligible age groups may be caused by indirect effects of the vaccination program. However, disentangling natural fluctuation from vaccine effect was not possible. Our findings encourage the use of toddler and teenager MenACWY vaccination in national immunization programs.
Imaging of the left atrium: pathophysiology insights and clinical utility
Authors: Smiseth Otto A , Baron Tomasz , Marino Paolo N , Marwick Thomas H , Flachskampf Frank A 
Published: September 2021

Abstract
Left atrial imaging and detailed knowledge of its pathophysiology, especially in the context of heart failure, have become an increasingly important clinical and research focus. This development has been accelerated by the growth of non-invasive imaging modalities, advanced image processing techniques, such as strain imaging, and the parallel emergence of catheter-based left atrial interventions like pulmonary vein ablation, left atrial appendage occlusion, and others. In this review, we focus on novel imaging methods for the left atrium, their pathophysiological background, and their clinical relevance for various cardiac conditions and diseases.
Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection
Authors: Cui Hongtu , Chen Yanghui , Li Ke , Zhan Rui , Zhao Mingming , Xu Yangkai , Lin Zhiyong , Fu Yi , He Qihua , Tang Paul C , Lei Ienglam , Zhang Jifeng , Li Chenze , Sun Yang , Zhang Xinhua , Horng Tiffany , Lu Hong S , Chen Y Eugene , Daugherty Alan , Wang Daowen , Zheng Lemin 
Published: September 2021

Abstract

Aims
Aortic aneurysm and dissection (AAD) are high-risk cardiovascular diseases with no effective cure. Macrophages play an important role in the development of AAD. As succinate triggers inflammatory changes in macrophages, we investigated the significance of succinate in the pathogenesis of AAD and its clinical relevance.

Methods and results
We used untargeted metabolomics and mass spectrometry to determine plasma succinate concentrations in 40 and 1665 individuals of the discovery and validation cohorts, respectively. Three different murine AAD models were used to determine the role of succinate in AAD development. We further examined the role of oxoglutarate dehydrogenase (OGDH) and its transcription factor cyclic adenosine monophosphate-responsive element-binding protein 1 (CREB) in the context of macrophage-mediated inflammation and established p38αMKO Apoe –/– mice. Succinate was the most upregulated metabolite in the discovery cohort; this was confirmed in the validation cohort. Plasma succinate concentrations were higher in patients with AAD compared with those in healthy controls, patients with acute myocardial infarction (AMI), and patients with pulmonary embolism (PE). Moreover, succinate administration aggravated angiotensin II-induced AAD and vascular inflammation in mice. In contrast, knockdown of OGDH reduced the expression of inflammatory factors in macrophages. The conditional deletion of p38α decreased CREB phosphorylation, OGDH expression, and succinate concentrations. Conditional deletion of p38α in macrophages reduced angiotensin II-induced AAD.

Conclusion
Plasma succinate concentrations allow to distinguish patients with AAD from both healthy controls and patients with AMI or PE. Succinate concentrations are regulated by the p38α–CREB–OGDH axis in macrophages.
Care and management of adults with autism spectrum disorder in family practice: difficulties experienced by general practitioners
Authors: Voillemont Cyrielle , Imbault Eric , Schoenberger Marie , Di Patrizio Paolo 
Published: September 2021

Abstract

Background and objectives
Few studies exist regarding the management and support of adults with autism spectrum disorder (ASD) in family practice. Most of them concern the management of children. As a primary care professional however, the general practitioner (GP) has a role to play at every step of the autistic adult’s care pathway. With this study, we sought to identify GPs’ experienced difficulties in caring for and managing their adult patients with ASD.

Methods
We conducted a qualitative study of 11 French GPs caring for adults with ASD via semistructured interviews and a thematic content analysis. GPs were recruited from 5 counties of the Grand Est Region (Marne, Haute-Marne, Meurthe-et-Moselle, Meuse and Vosges).

Results
All of the GPs described difficulties with the diagnostic process and the lack of initial training. Most of the respondents expressed difficulties with medical consultations of patients presenting an intellectual disability (ID) and with the lack of communication between GPs and mental health specialists during the patient care process. More than half of the GPs described difficulties with referral pathways for diagnosis due to lengthy delays and patient reluctance to seek psychiatric care. More than half of the respondents also experienced difficulties with providing proper social care, and with responding to patient distress due to their healthcare experiences.

Conclusion
Improving awareness and training about ASD in adults, as well as harmonizing the diagnostic process and referral pathways, might reduce GPs’ experienced difficulties in caring for this population.
Biomodification of acenocoumarol by bifidobacteria
Authors: Fragomeno Melisa , Assad Sabrina , Mobili Pablo , Peruzzo Pablo J , Minnaard Jessica , Pérez Pablo Fernando 
Published: September 2021

ABSTRACT
The increased interest of consumers in probiotic foods requires a deeper knowledge on the possible interactions with drugs, because their pharmacological properties could be modified. In this context, these studies are relevant for drugs such as acenocoumarol, whose dosage must be controlled due to, among other factors, food-drug interactions. Acenocoumarol is an oral anticoagulant with a narrow therapeutic range. The aim of the present research is to evaluate, in vitro, the effect of bifidobacteria on acenocoumarol. The drug was incubated with Bifidobacterium bifidum CIDCA 5310 or Bifidobacterium adolescentis CIDCA 5317 in MRS broth at 37°C for 24 h in anaerobic conditions. The effect of incubation with sterilized spent culture supernatants (SSCS) was also evaluated. Analysis by RP-HPLC showed that both bifidobacterial strains reduced the area of the acenocoumarol peak and two new peaks were evidenced. In addition, a decrease in the intensity of the bands at 1650, 1390 and 1110/cm was observed in the FTIR spectroscopic determinations. Moreover, a new band appeared at 1720/cm. No effect on the drug was observed when incubation was performed with SSCS. The present study showed a significant change in the concentration of the anticoagulant after incubation with bifidobacteria and results are compatible with biomodification of the drug due to enzymatic activity of bifidobacteria.
Theories of Community Collaboration to Advance Age-Friendly Community Change
Authors: Greenfield Emily A , Black Kathy , Oh Patricia , Pestine-Stevens Althea 
Published: September 2021

Abstract
The age-friendly communities movement has grown rapidly in global prominence over the past 2 decades. However, theories to guide multisectoral action toward age-friendly community change have been slower to develop. We demonstrate the value of drawing on theories of community collaboration to inform age-friendly community efforts across engagement, planning, implementation, and measurement. We introduce 3 theories—Asset-Based Community Development, Strategic Doing, and Collective Impact—each with principles and strategies for guiding multisectoral group processes toward long-term and systematic community change. While distinct from each other, these theories collectively suggest the importance of incorporating a more explicit community-building approach within the age-friendly communities movement. We describe the implications of this integrative theory development for bolstering sustainable and comprehensive practices and policies to improve environments for aging across diverse communities.
Comment on ‘Piezoelectricity as a mechanism on generation of electromagnetic precursors before earthquakes’ by J.H. Wang
Authors: Yamazaki Ken'ichi 
Published: September 2021

SUMMARY
Wang (2021, hereafter JHW) recently investigated elastic–electric coupling (EEC) in terms of the piezoelectric effect to assess both the plausibility of and necessary conditions for generating pre-earthquake electromagnetic phenomena, including variations in the total electron content (TEC). The study considered a 1-D model to simulate the piezoelectric effect, and derived a quantitative relationship between the dislocation and intensity of the electric field. One of JHW's conclusions was that the piezoelectric effect is a potential mechanism for generating previously reported pre-earthquake TEC anomalies. However, the quantitative discussion in JHW contains a serious error. JHW had chosen an incorrect mode between the two solutions during the derivation of a quantitative relationship between the displacement and the electric field, which subsequently led to an incorrect estimation of the ratio of the generated electric field to the displacement. The opposite conclusion to that drawn by JHW is attained when a correct mode is used.
Moving from community-based to health centre-based management: impact on urban community health worker performance in Ethiopia
Authors: Ludwick Teralynn , Endriyas Misganu , Morgan Alison , Kane Sumit , McPake Barbara 
Published: September 2021

Abstract
Community health worker (CHW) performance is influenced by the way in which management arrangements are configured vis-a-vis the community and health services. While low-/middle-income contexts are changing, the literature provides few examples of country efforts to strategically modify management arrangements to support evolving CHW roles (e.g. chronic disease care) and operating environments (e.g. urbanization). This paper aims to understand the performance implications of changing from community-based to health centre-based management, on Ethiopia’s Urban Health Extension Professionals (UHEPs), and the tensions/trade-offs associated with the respective arrangements. We conducted semi-structured interviews/focus groups to gather perspectives and preferences from those involved with the transition (13 managers/administrators, 5 facility-based health workers and 20 UHEPs). Using qualitative content analysis, we deductively coded data to four programme elements impacted by changed management arrangements and known to affect CHW performance (work scope; community legitimacy; supervision/oversight/ownership and facility linkages) and inductively identified tensions/trade-offs. Community-based management was associated with wider work scope, stronger ownership/regular monitoring, weak technical support and weak health centre linkages, with opposite patterns observed for health centre-led management. Practical trade-offs included: heavy UHEP involvement in political/administrative activities under Kebele-based management; resistance to working with UHEPs by facility-based workers and health centre capacity constraints in managing UHEPs. Whereas the Ministry of Health/UHEPs favoured the health centre-led management to capitalize on UHEPs’ technical skills, Kebele officials were vested in managing UHEPs and argued for community interests over UHEPs’ professional interests; health facility managers/administrators held divided opinions. Management arrangements influence the nature of CHW contributions towards the achievement of health, development and political goals. Decisions about appropriate management arrangements should align with the nature of CHW roles and consider implementation setting, including urbanization, political decentralization and relative capacity of managing institutions.
Influence of Preseason Antibodies Against Influenza Virus on Risk of Influenza Infection Among Healthcare Personnel
Authors: Gorse Geoffrey J , Rattigan Susan M , Kirpich Alexander , Simberkoff Michael S , Bessesen Mary T , Gibert Cynthia , Nyquist Ann-Christine , Price Connie Savor , Gaydos Charlotte A , Radonovich Lewis J , Perl Trish M , Rodriguez-Barradas Maria C , Cummings Derek A T 
Published: September 2021

Abstract

Background
The association of hemagglutination inhibition (HAI) antibodies with protection from influenza among healthcare personnel (HCP) with occupational exposure to influenza viruses has not been well-described.

Methods
The Respiratory Protection Effectiveness Clinical Trial was a cluster-randomized, multisite study that compared medical masks to N95 respirators in preventing viral respiratory infections among HCP in outpatient healthcare settings for 5180 participant-seasons. Serum HAI antibody titers before each influenza season and influenza virus infection confirmed by polymerase chain reaction were studied over 4 study years.

Results
In univariate models, the risk of influenza A(H3N2) and B virus infections was associated with HAI titers to each virus, study year, and site. HAI titers were strongly associated with vaccination. Within multivariate models, each log base 2 increase in titer was associated with 15%, 26% and 33%–35% reductions in the hazard of influenza A(H3N2), A(H1N1), and B infections, respectively. Best models included preseason antibody titers and study year, but not other variables.

Conclusions
HAI titers were associated with protection from influenza among HCP with routine exposure to patients with respiratory illness and influenza season contributed to risk. HCP can be reassured about receiving influenza vaccination to stimulate immunity.
Effect of the Mini-Nutritional Assessment-Short Form in Elderly Burn Patients
Authors: Wei Jia-Yu , Shi Shu-Ting , Sun Dan , Lyu Guo-Zhong 
Published: September 2021

Abstract
Nutritional assessment can early identify patients who are malnourished and at risk of malnutrition. To examine the effect of nutritional status on wound healing in elderly burn patients, we used the Mini-Nutritional Assessment-Short Form (MNA-SF) to measure the nutritional status of elderly patients. This study aimed to examine the role of MNA-SF in elderly burn patients through the correlation analysis of wound healing indicators and MNA-SF score. This was a prospective observational and cross-sectional study. This study used the MNA-SF to investigate the elderly burn patients at the department of burn. According to the score, the patients fell into three groups: good nutritional status (more than 12 points), malnutrition risk (8–11 points), and malnutrition (0–7 points). At the same time, we measured and compared the wound healing indicators among the three groups of patients, and detected the correlation. The results showed gender had a slight influence on the score of nutritional status, while age was negatively correlated with the MNA-SF score and nutrition-related indicators. There was a low positive linear correlation between the wound healing percent area change or wound healing rate of patients and the score of the MNA-SF. This study finds malnutrition is common among hospitalized elderly burn patients. The application of the MNA-SF in elderly burn patients is efficient and accurate to identify malnutrition early and prevent further obstruction of the normal wound healing, which can provide reference points for early nutrition intervention programs.
The Impact of Race/Ethnicity on the Outcomes of Burn Patients: A Systematic Review of the Literature
Authors: Peters Jasmine , Bello Mariel S , Spera Leigh , Gillenwater T Justin , Yenikomshian Haig A 
Published: September 2021

Abstract
Racial and ethnic disparities are endemic to the United States and are only beginning to attract the attention of researchers. With an increasingly diverse population, focused and tailored medicine to provide more equitable care is needed. For surgical trauma populations, this topic is a small but expanding field and still rarely mentioned in burn medicine. Disparities in prevention, treatment, and recovery outcomes between different racial and ethnic minorities who are burned are rarely discussed. The purpose of this study is to determine the current status of identified disparities of care in the burn population literature and areas of future research. A systematic review was conducted of literature utilizing PubMed for articles published between 2000 and 2020. Searches were used to identify articles that crossed the burn term (burn patient OR burn recovery OR burn survivor OR burn care) and a race/ethnicity and insurance status-related term (race/ethnicity OR African-American OR Black OR Asian OR Hispanic OR Latino OR Native American OR Indigenous OR Mixed race OR 2 or more races OR socioeconomic status OR insurance status). Inclusion criteria were English studies in the United States that discussed disparities in burn injury outcomes or risk factors associated with race/ethnicity. One thousand one hundred and sixty-nine papers were populated, 55 were reviewed, and 36 articles met inclusion criteria. Most studies showed minorities had poorer inpatient and outpatient outcomes. While this is a concerning trend, there is a paucity of literature in this field and more research is needed to create culturally tailored medical care and address the needs of disadvantaged burn survivors.
Cranial variation in the Altai weaselMustela altaica(Carnivora: Mustelidae) and its possible taxonomic implications
Authors: Abramov Alexei V , Puzachenko Andrey Y U 
Published: September 2021

AbstractThe Altai weasel, Mustela altaicaPallas 1811 (Carnivora: Mustelidae), is widely distributed across open landscapes of central and eastern Asia. The geographical variation in skull morphology and taxonomic composition of this small mustelid remain poorly known. Based on extensive sampling in museum collections, we analyzed morphometric variation in 23 cranial characters of 232 M. altaica specimens from across its entire range. The multivariate analysis (nonmetric multidimensional scaling) revealed a geographical pattern of variation in cranial size and shape. Based on this result, two morphological groups have been comprehensively characterized. Weasels of the first group differ from those of the second in having larger skulls, wider neurocrania, elongated toothrows, and larger carnassial teeth, as well as in sexual size dimorphism. The first group is confined to the southwestern part of the species range (Tien Shan Mountains, Pamir, the Himalayas, and southern Tibet). The second group is widespread from the foothills of Tien Shan in the west to Khingan and Manchuria in the east. The distribution of the two groups of M. altaica is consistent with the “Out-of-Tibet” hypothesis. The first group presumably can be attributed to M. a. temonHodgson, 1857, whereas the second group can be treated as nominotypical M. a. altaicaPallas, 1811.