bluuebunny/crossref_metadata_2025_split huggingface dataset:
Análise dos marcos do desenvolvimento em prematuros utilizando a Escala Bayley
Authors: Souza dos Santos Ligiane , Soria Lilian Cristina Munhoz , Santos Janaina Senhorini dos , Antoniucci Juliana Marinho , Rodrigues Olga Maria Piazentin Rolim 
Published: November 2021

Prematuros apresentam risco aumentado para atrasos na aquisição de habilidades neuromotoras. Os marcos do desenvolvimento preconizam que um bebê a termo de seis meses seja capaz de manter-se sentado com apoio, aos nove meses se locomova utilizando o movimento de engatinhar e, aos 12 meses, troque passos com apoio. Esse estudo pretendeu analisar o desenvolvimento motor grosseiro de bebês nascidos pré termo quanto a aquisição das habilidades do sentar, engatinhar e andar, utilizando os escores da Escala Bayley-III, aplicada aos seis, nove e 12 meses em participantes de um programa de intervenção precoce, relacionando-as ao sexo e idade gestacional. Observou-se que dos 129 participantes, 37,21% dos bebês sentaram com apoio por 30 segundos aos seis meses. Quanto a série engatinhar, avaliada aos nove meses, 27,91% dos bebês apresentaram o movimento nesta idade. Aos 12 meses, a maioria dos participantes (82,17%) apresentou o andar com apoio, o esperado para a idade. Considerando sexo e idade gestacional,
observou-se que quanto menos semanas gestacionais menos bebês alcançaram as metas para a idade/mês e essa ocorrência é mais frequente em meninos.
FEASIBILITY STUDY OF ORNAMENTAL PLANT BUSINESS IN COVID PANDEMIC AT BATURAJA OKU SOUTH SUMATERA
Authors: Sari Fifian Permata , Munajat Munajat 
Published: November 2021

The ornamental plant business is a very profitable and promising venture, made even more so by the fact that there is an ornamental plant trend at the start of 2019. Certain types of ornamental plants can be quite expensive, and some customers are willing to pay a premium for them to add to their ornamental plant collection. As a result, the number of florists has increased, particularly in Baturaja City. During the Covid-19 pandemic, numerous businesses, including ornamental plant businesses, suffered financial losses. Some businesses have been unable to survive due to losses as a result of people's limited purchasing power for ornamental plants. The goal of this research is to determine the viability of the ornamental plant business in Baturaja, especially in the event of a pandemic. In this study, the census method was used, and the saturated sampling method was used for sampling. The analysis was carried out using a feasibility analysis with R/C ratio analysis. In Baturaja, data was gathered from 15 ornamental plant business actors. With an R/C of 1.65, the study's findings indicated that the ornamental plant business in the city of Baturaja would be viable in the event of a pandemic.
Keywords: Feasibility study, ornamental plant business, pandemic Covid

Abstrak
Bisnis tanaman hias merupakan bisnis yang sangat menjanjikan dan menguntungkan, apalagi setelah terjadi trend tanaman hias di awal tahun 2019. Beberapa jenis tanaman hias dapat dijual dengan harga yang tinggi dan konsumen mau membeli dengan harga tinggi tersebut, untuk menambah koleksi. Fenomena ini juga terjadi di kota Baturaja. Selama pandemi Covid-19, banyak bisnis yang merugi, termasuk bisnis tanaman hias. Turun nya daya beli masyarakat juga berpengaruh terhadap bisnis tanaman hias. Membuat para pelaku usaha bisnis ini tidak mampu bertahan karena merugi. Penelitian ini bertujuan untuk menganalisis kelayakan usaha tanaman hias di kota Baturaja khususnya pada masa pandemi Covid-19. Metode yang digunakan dalam penelitian ini adalah metode sensus dan metode penarikan contoh yang digunakan adalah metode acak jenuh. Metode analisis yang digunakan dalam pengolahan data penelitian adalah analisis kelayakan menggunakan R/C ratio. Sedangkan data yang dikumpulkan berasal dari 15 pelaku usaha tanaman hias di kota Baturaja. Hasil penelitian menunjukkan bahwa usaha tanaman hias di kota Baturaja di masa pandemic Covid masih layak untuk terus diusahakan dengan nilai R/C sebesar 1.65.
Kata kunci: Analisis kelayakan, bisnis tanaman hias, pandemic Covid
THE ROLE OF BUSINESS TRUST, CONSUMER CONFIDENCE AND THE DEVELOPMENT OF INFORMATION AND COMMUNICATION TECHNOLOGY ON ECONOMIC GROWTH IN G20 COUNTRIES
Authors: Syahputra Hardiansa Nur , Marselina Marselina , Aida Neli 
Published: November 2021

This study aims to analyze the condition of business trust, consumer trust, rule of law, developments in technology,information, and communication, and their influence on ASEAN economic growth. The data used is panel dataconsisting of time series data for 2009 – 2020 and a cross-section of 10 countries with the highest level of businessconfidence in G20 Member countries. The variables used are economic growth, conditions of business trust,consumer confidence, rule of law, development of technology, information, and communication. The analyticaltool used is panel data regression, namely the Fixed Effect Model (FEM). An increase in business confidence andconsumer confidence will have an impact on increasing economic growth. In the research results, business trust has the most influence.
Keywords: Economic Growth, Conditions of Business Trust, and Consumer Confidence.

Abstrak
Penelitian ini bertujuan untuk menganalisis kondisi kepercayaan bisnis, kepercayaan konsumen, supremasi hukum, perkembangan teknologi, informasi, dan komunikasi, serta pengaruhnya terhadap pertumbuhan ekonomi ASEAN. Data yang digunakan adalah data panel yang terdiri dari data time series tahun 2009 – 2020 dan cross section dari 10 negara dengan tingkat kepercayaan bisnis tertinggi di negara-negara Anggota G20. Variabel yang digunakan adalah pertumbuhan ekonomi, kondisi kepercayaan bisnis, kepercayaan konsumen, supremasi hukum, perkembangan teknologi, informasi, dan komunikasi. Alat analisis yang digunakan adalah regresi data panel yaitu Fixed Effect Model (FEM). Meningkatnya kepercayaan bisnis dan kepercayaan konsumen akan berdampak pada peningkatan pertumbuhan ekonomi. Dalam hasil penelitian, kepercayaan bisnis memiliki pengaruh paling besar.
Kata Kunci: Pertumbuhan Ekonomi, Kepercayaan Bisnis, dan Kepercayaan Konsumen.
NON-TAX STATE REVENUE (PNBP) IN PUBLIC WATER FISHERIES RESEARCH CENTERS AND FISHERIES EXPLANATION (BRPPUPP)
Authors: Putri Tike Dwi 
Published: November 2021

This study aims to analyze Non-Tax State Revenue (PNBP) at the Public Water Fisheries Research Institute and Fisheries Extension (BRPPUPP) Tax in terms of recording accuracy, management compliance, and effectiveness. then analyzed using descriptive qualitative analysis method. The results of this study indicate that the percentage of PNBP for the Public Water Fisheries Research Center and Fisheries Extension in 2019 the realization of PNBP receipts does not reach the target which shows that the performance of achieving the target is 89.5%, while the amount of revenue in 2020 illustrates the effectiveness of the PNBP policy exceeding the target of 198.9 %.
Keywords: PNBP, BRPPUPP

Abstrak
Penelitian ini bertujuan untuk menganalisa Penerimaan Negara Bukan Pajak (PNBP) di Balai Riset Perikanan Perairan Umum dan Penyuluhan Perikanan (BRPPUPP) Pajak yang ditinjau dari sisi keakuratan pencatatan, kepatuhan pengelolaan, serta tingkat keefektifan. kemudian dianalisis dengan menggunakan Metode analisis deskriptif kualitatif. Hasil penelitian ini menjukan bahwa persentase PNBP untuk di Balai Riset Perikanan Perairan Umum dan Penyuluhan Perikanan di tahun 2019 realisasi penerimaan PNBP tidak mencapai target yang menunjukan bahwa kinerja pencapaian target sebesar 89.5%, Sedangkan jumlah penerimaan pada tahun 2020 menggambarkan keefektifan kebijakan PNBP melebihi target sebesar 198.9%.
Kata kunci: PNBP,BRPPUPP
Ab Initio Calculations for the Electronic, Interfacial and Optical Properties of Two-Dimensional AlN/Zr2CO2 Heterostructure
Authors: Ren Kai , Zheng Ruxin , Lou Junbin , Yu Jin , Sun Qingyun , Li Jianping 
Published: November 2021

Recently, expanding the applications of two-dimensional (2D) materials by constructing van der Waals (vdW) heterostructures has become very popular. In this work, the structural, electronic and optical absorption performances of the heterostructure based on AlN and Zr2CO2 monolayers are studied by first-principles simulation. It is found that AlN/Zr2CO2 heterostructure is a semiconductor with a band gap of 1.790 eV. In the meanwhile, a type-I band structure is constructed in AlN/Zr2CO2 heterostructure, which can provide a potential application of light emitting devices. The electron transfer between AlN and Zr2CO2 monolayer is calculated as 0.1603 |e| in the heterostructure, and the potential of AlN/Zr2CO2 heterostructure decreased by 0.663 eV from AlN layer to Zr2CO2 layer. Beisdes, the AlN/Zr2CO2 vdW heterostructure possesses excellent light absorption ability of in visible light region. Our research provides a theoretical guidance for the designing of advanced functional heterostructures.
The Ratio of NT-proBNP to CysC1.53 Predicts Heart Failure in Patients With Chronic Kidney Disease
Authors: Wang Sheng , Li Ming , Wang Xiangyu , Luo Jing , Zou Yulin , Hu Yang , Liu Xingtai , Ao Hua , Yao Xueer , Li Chufeng , Yang Tingting 
Published: November 2021

Background: The N-terminal pro B type natriuretic peptide (NT-proBNP) is important for prognosis of heart failure in patients with chronic kidney disease (CKD). However, the NT-proBNP level is easily affected by renal insufficiency, which limits its clinical use.Methods: This study included 396 patients with CKD. Plasma levels of NT-proBNP and cystatin C (CysC) were measured during hospitalization. The echocardiographic parameters were also detected. Patients were divided into the heart failure group and control group according to the European Society of Cardiology Guideline on Chronic Heart Failure 2021. Multiple modeling analysis of the values of NT-proBNP and CysC, including NT-proBNP/Cyscn and NT-proBNP/nCysC was performed. The receiver operating characteristic (ROC) curve, combined with the cardiac function, was used to determine the formula with the best diagnostic efficiency. Then, the sensitivity and specificity of new predictors for cardiac insufficiency in CKD patients were calculated. Pearson correlation analysis was used to analyze the relationship between new predictors and the NT-proBNP level. The clinical data of CKD patients from another local hospital were used to validate the new predictors and the cut-off values.Results: An elevated NT-proBNP/CysC1.53 ratio was an independent risk factor for cardiac dysfunction in CKD and the best predictor derived from multiple modeling analysis. There was no correlation between the NT-proBNP/CysC1.53 ratio and the NT-proBNP level (r = 0.376, p = 6.909). The area under the ROC curve for the NT-proBNP/CysC1.53 ratio was 0.815 (95% confidence interval: 0.772–0.858), and for a cut-off point of 847.964, this ratio had a sensitivity of 78.24%, and a specificity of 69.44%. When applied to the data of CKD patients from another local hospital, the NT-proBNP to CysC1.53 ratio had a sensitivity of 70.27% and a specificity of 67.74%.Conclusion: The NT-proBNP to CysC1.53 ratio was superior to NT-proBNP alone for predicting cardiac dysfunction in patients with CKD.
ECG Predictors for New-Onset Atrial Fibrillation Within a Year After Radiofrequency Ablation of Counterclockwise-Rotating Atrial Flutter
Authors: Liu Hailei , Gu Zhoushan , Zhu Chao , Li Mingfang , Jiao Jincheng , Chen Hongwu , Yang Gang , Ju Weizhu , Gu Kai , Zhang Fengxiang , Chen Lin Yee , Yang Di , Chen Minglong 
Published: November 2021

Background: New-onset atrial fibrillation (AF) after ablation of typical atrial flutter (AFL) is not rare. This study aimed to investigate the predictive value of electrocardiographic parameters on new-onset AF post-typical AFL ablation.Methods: A total of 158 consecutive patients (79.1% males, mean age 57.8 ± 14.3 years) with typical AFL were enrolled between January 2012 and August 2017 in this single-center study. Patients with a history of AF before ablation were excluded. ECGs during sinus rhythm (SR) and AFL were collected. The duration of the negative component of flutter wave in lead II (DFNII), proportion of the DFNII of the total circle length of AFL (DFNII%), amplitude of the negative component of flutter wave in lead II (AFNII), duration (DPNV1), and amplitude (APNV1) of negative component of the P wave in lead V1, and P wave duration in lead II (DPII) during sinus rhythm were measured.Results: During a median follow-up of 26.9 ± 11.8 months, 22 cases (13.9%) developed new-onset AF. DFNII was significantly longer in patients with new-onset AF compared to patients without AF (114.7 ± 29.6 ms vs. 82.7 ± 12.8 ms, p &lt; 0.0001). AFNII was significantly lower (0.118 ± 0.034 mV vs. 0.168 ± 0.051 mV, p &lt; 0.0001), DPII (144.21 ± 23.77 ms vs. 111.46 ± 14.19 ms, p &lt; 0.0001), and DPNV1 was significantly longer (81.07 ± 16.87 ms vs. 59.86 ± 14.42 ms, p &lt; 0.0001) in patients with new-onset AF. In the multivariate analysis, DFNII [odds ratio (OR), 1.428; 95% CI, 1.039–1.962; p = 0.028] and DPII (OR, 1.429; 95% CI, 1.046–1.953; p = 0.025) were found to be independently associated with new-onset AF after typical AFL ablation.Conclusion: Parameters representing left atrial activation time under both the SR and AFL were independently associated with new-onset AF post-typical AFL ablation and may be useful in risk prediction, which needs to be confirmed by further prospective studies.
Underground Hydro-Pumped Energy Storage Using Coal Mine Goafs: System Performance Analysis and a Case Study for China
Authors: Jiang Deyi , Chen Shao , Liu Wenhao , Ren Yiwei , Guo Pengyv , Li Zongze 
Published: November 2021

In response to the Paris climate agreement, the Chinese government has taken actions to improve the energy structure by reducing the share of coal-fired thermal power and increasing the use of clean energy. However, due to the extreme shortage of large-scale energy storage facilities, the utilization efficiency of wind and solar power remains low. This paper proposes to use abandoned coal mine goafs serving as large-scale pumped hydro storage (PHS) reservoir. In this paper, suitability of coal mine goafs as PHS underground reservoirs was analyzed with respects to the storage capacity, usable capacity, and ventilation between goaf and outside. The storage capacity is 1.97 × 106 m3 for a typical mining area with an extent of 3 × 5 km2 and a coal seam thickness of 6 m. A typical goaf-PHS system with the energy type αw=0.74 has a performance of 82.8% in the case of annual operation, able to regulate solar-wind energy with an average value of 275 kW. The performance of the proposed goaf-PHS system was analyzed based on the reservoir estimation and meteorological information from a typical region in China. It has been found that using abandoned coal mine goafs to develop PHS plants is technically feasible in wind and solar-rich northwestern and southwestern China.
A Novel Risk-Score Model With Eight MiRNA Signatures for Overall Survival of Patients With Lung Adenocarcinoma
Authors: Wu Jun , Lou Yuqing , Ma Yi-Min , Xu Jun , Shi Tieliu 
Published: November 2021

Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer with heterogeneous outcomes and diverse therapeutic responses. To classify patients into different groups and facilitate the suitable therapeutic strategy, we first selected eight microRNA (miRNA) signatures in The Cancer Genome Atlas (TCGA)-LUAD cohort based on multi-strategy combination, including differential expression analysis, regulatory relationship, univariate survival analysis, importance clustering, and multivariate combinations analysis. Using the eight miRNA signatures, we further built novel risk scores based on the predefined cutoff and beta coefficients and divided the patients into high-risk and low-risk groups with significantly different overall survival time (p-value &lt; 2 e−16). The risk-score model was confirmed with an independent dataset (p-value = 4.71 e−4). We also observed that the risk scores of early-stage patients were significantly lower than those of late-stage patients. Moreover, our model can also provide new insights into the current clinical staging system and can be regarded as an alternative system for patient stratification. This model unified the variable value as the beta coefficient facilitating the integration of biomarkers obtained from different omics data.
A Combined Nomogram Model to Predict Disease-free Survival in Triple-Negative Breast Cancer Patients With Neoadjuvant Chemotherapy
Authors: Xia Bingqing , Wang He , Wang Zhe , Qian Zhaoxia , Xiao Qin , Liu Yin , Shao Zhimin , Zhou Shuling , Chai Weimin , You Chao , Gu Yajia 
Published: November 2021

Background: To investigate whether the radiomics signature (Rad-score) of DCE-MRI images obtained in triple-negative breast cancer (TNBC) patients before neoadjuvant chemotherapy (NAC) is associated with disease-free survival (DFS). Develop and validate an intuitive nomogram based on radiomics signatures, MRI findings, and clinicopathological variables to predict DFS.Methods: Patients (n = 150) from two hospitals who received NAC from August 2011 to May 2017 were diagnosed with TNBC by pathological biopsy, and follow-up through May 2020 was retrospectively analysed. Patients from one hospital (n = 109) were used as the training group, and patients from the other hospital (n = 41) were used as the validation group. ROIs were drawn on 1.5 T MRI T1W enhancement images of the whole volume of the tumour obtained with a 3D slicer. Radiomics signatures predicting DFS were identified, optimal cut-off value for Rad-score was determined, and the associations between DFS and radiomics signatures, MRI findings, and clinicopathological variables were analysed. A nomogram was developed and validated for individualized DFS estimation.Results: The median follow-up time was 53.5 months, and 45 of 150 (30.0%) patients experienced recurrence and metastasis. The optimum cut-off value of the Rad-score was 0.2528, which stratified patients into high- and low-risk groups for DFS in the training group (p&lt;0.001) and was validated in the external validation group. Multivariate analysis identified three independent indicators: multifocal/centric disease status, pCR status, and Rad-score. A nomogram based on these factors showed discriminatory ability, the C-index of the model was 0.834 (95% CI, 0.761–0.907) and 0.868 (95% CI, 0.787–949) in the training and the validation groups, respectively, which is better than clinicoradiological nomogram(training group: C-index = 0.726, 95% CI = 0.709–0.743; validation group: C-index = 0.774,95% CI = 0.743–0.805).Conclusion: The Rad-score derived from preoperative MRI features is an independent biomarker for DFS prediction in patients with TNBC to NAC, and the combined radiomics nomogram improved individualized DFS estimation.
Reproduction in Animal Models of Lysosomal Storage Diseases: A Scoping Review
Authors: Vuolo Daniela , Do Nascimento Cinthia Castro , D’Almeida Vânia 
Published: November 2021

Background:Lysosomal storage diseases (LSDs) are caused by a mutation in a specific gene. Enzymatic dysfunction results in a progressive storage of substrates that gradually affects lysosomal, cellular and tissue physiology. Their pathophysiological consequences vary according to the nature of the stored substrate, making LSDs complex and multisystemic diseases. Some LSDs result in near normal life expectancies, and advances in treatments mean that more people reach the age to have children, so considering the effects of LSDs on fertility and the risks associated with having children is of growing importance.Objectives:As there is a lack of clinical studies describing the effect of LSDs on the physiology of reproductivity, we undertook a scoping review of studies using animal models of LSDs focusing on reproductive parameters.Methods:We searched six databases: MEDLINE, LILACS, Scopus, Web of Science, Embase and SciELO, and identified 49 articles that met our inclusion criteria.Results:The majority of the studies used male animal models, and a number reported severe morphological and physiological damage in gametes and gonads in models of sphingolipidoses. Models of other LSDs, such as mucopolysaccharidoses, presented important morphological damage.Conclusion:Many of the models found alterations in reproductive systems. Any signs of subfertility or morphological damage in animal models are important, particularly in rodents which are extremely fertile, and may have implications for individuals with LSDs. We suggest the use of more female animal models to better understand the physiopathology of the diseases, and the use of clinical case studies to further explore the risks of individuals with LSDs having children.
Regional Brain Volume, Brain Reserve and MMSE Performance in Healthy Aging From the NEUROAGE Cohort: Contributions of Sex, Education, and Depression Symptoms
Authors: Pettemeridou Eva , Kallousia Eleni , Constantinidou Fofi 
Published: November 2021

Objective: The aim of this study was twofold. First, to investigate the relationship between age, gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) volumes, brain reserve (BR), and specific regions of interest (ROIs) with global cognitive function in healthy older adults participating in a longitudinal study on aging in the island country of Cyprus. Second, to assess the contribution of important demographic and psychosocial factors on brain volume. Specifically, the effects of sex and years of education and the association between depression symptoms on brain volume were also explored in this Mediterranean cohort.Methods: Eighty-seven healthy older adults (males = 37, females = 50) scoring ≥24 on the Mini-Mental State Examination (MMSE) were included, with a mean age of 72.75 years and a mean educational level of 10.48 years. The Geriatric Depression Scale was used to assess depression. T1-weighted magnetic resonance images were used to calculate global and regional volumes.Results: Age was negatively correlated with GM, WM, BR, MMSE scores, and ROIs, including the hippocampus, amygdala, entorhinal cortex, prefrontal cortex, anterior cingulate gyrus, and positively with CSF. Higher MMSE scores positively correlated with GM volume. Women exhibited greater levels of depression than men. Depression was also negatively correlated with GM volume and MMSE scores. Men had greater ventricular size than women and participants with higher education had greater ventricular expansion than those with fewer years in education.Conclusions: The reported structural changes provide evidence on the overlap between age-related brain changes and healthy cognitive aging and suggest that these age changes affect certain regions. Furthermore, sex, depressive symptomatology, and education are significant predictors of the aging brain. Brain reserve and higher education accommodate these changes and works against the development of clinical symptoms.