bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable Fashion as a Research Object in Foreign Scientific Literature
Authors: Pokhodenko Kateryna 
Published: December 2021

The concept of sustainability in fashion, having been developed on the basis of ecodesign concepts, takes an important place in scientific research all over the world. The aim of study is to analize and summarise foreign scientific researches about sustainability in fashion. The results were achieved by using methods of sources analysis, which refer to different research fields, in the context of sustainable fashion and their further synthesis according to areas. The main directions of research in each area were identified and summarized in the conclusions.
There were considered basic concept definitions – sustainable fashion and the principles of sustainable design, which are used in modern scientific works of foreign researchers. The analysis of foreign scientific sources in the context of sustainable fashion was provided in areas of: economics, marketing, management; sociology and psychology of consumer behavior; ecology; technologies based on the principles of sustainable design; design; aesthetics and art history; education; legislation; information technology. The scientific value of study. For the first time the systematization of foreign research in the context of sustainable fashion was carried out. The conclusions are given after the analysis of each area, underlining the main directions of foreign scientists` research.
Conclusions. Researchers from all over the world pay attention to the issues of sustainable fashion and explore problems of the integration of sustainable fashion into everyday life. Sustainable fashion sets up new values that actualize the issues of aesthetics of sustainable fashion in the theory of art history and design practice. However, it should be noted that the analized scientific works concerning fashion design in the context of sustainable fashion, do not reveal aspects of design related to the creative process and aesthetic perception. Sustainable fashion needs changes of existing design tools in the context of sustainable design principles. Therefore, there is a need for their further study.
SLOPE STABILITY ASSESSMENT OF THE UPSTREAM SLOPE OF THE DRY MOUNTAIN FLOOD CONTROL RESERVOIR DURING THE FLOOD
Authors: Velychko Svitlana , Dupliak Olena , Kurbanova Tetiana 
Published: December 2021

The flood control is one of the priority goal for successful economic activity on the areas that are periodically suffer from floods. Such areas are the mountainous regions of the Ukrainian Carpathian Mountains. Floods on the mountain rivers are repeated several times each year, and are characterized by the sudden water level rise with almost the same rapid decrease of the water level. Active flood protection measures include dry mountain flood control reservoirs, the principle of which is to transform part of the flood runoff and to accumulate water for the short time in the the artificial reservoir, with followed rapid emptying to the minimum level. The complex hydraulic regime is formed in the body of the dam which forms the flood control reservoir during the flood, that is different from the operation of the water permanent reservoir. The design of the flood control structures is car-ried out in accordance with Ukrainian building codes for the construction of the water reservoirs with constant water level, and require testing the stability of the downstream slope for the maximum water levels under steady state seepage conditions and assessment the upstream slope stability during the water level decreasing from the maximum level calculated in the steady state condition, these calculations do not correspond to the real seepage processes in the body of the dam of the dry flood control reservoir. Therefore, the purpose of this work is to determine the necessary boundary conditions of the flood control reservoir operation and upstream slope stability assessment by the limit equilibrium method. In the article the operation of the dry mountain flood control reservoir was analysed and found that the dam was characterized by two states: dry reservoir with water minimum water level and variable position of the seepage curve in the core and the upstream prism during the flood. The main factors influencing the upstream slope stability are the physical and mechanical properties of the soil, the laying of the slope, the period of time when the high-water level is maintained and the intensity of water level dropping. The upstream slope stability was evaluated by the Morgenstern & Price and Ordinary methods on the Slope/w software package. After the first 25 hours of the flood (period of high-water levels and the next water level dropping) the Safety Factor evaluated by limit equilibrium methods began to decrease, and reached the minimum value during the greatest seepage curve gradients at the time between 45 and 50 hours. Slope stability calculations by the limit equilibrium method were compared with the results of calculations performed by the SRM method, the values ​​of the Safety Factor and the way of their change during the flood evaluated by Ordinary and SRM methods almost coincide, which indicates the reliability of the results obtained by different methods of slope stability analysis
Умови застосування методу власного випромінювання при вирішенні задач технічної діагностики напівпровідникових структур
Authors: Кузавков Василь , Романенко Марія , Болотюк Юлія 
Published: December 2021

В статті розглянуто особливості застосування методу власного випромінювання для складних напівпровідникових структур (мікропроцесорів, мікроконтролерів, програмовано-логіних інтегральних схемах та ін.)
Метод власного випромінювання пов’язаний з реєстрацією параметрів електромагнітного поля в інфрачервоному діапазоні хвиль. Параметри цього випромінювання безпосередньо залежать від температури об’єкту контролю – температури напівпровідникової структури. Використання температури в якості діагностичного параметру вимагає аналітичного опису процесів в напівпровідникових структурах, а саме фізико-хімічних процесів пов’язаних з термодинамічними властивостями кристалічної структури та поверхні, яка ізолює кристал від зовнішнього середовища.
З метою активації функціональних вузлів, які входять до складу великих інтегральних схем в запропонованому методі використовується спеціально підготовлена тестова послідовність. Довжина зазначеної послідовності повинна забезпечити вихід температурного процесу на сталий режим. Однак, при цьому можливе спотворення діагностичної інформації внаслідок взаємного впливу температури від сусідніх функціональних вузлів. В роботі визначено час реєстрації (довжину активуючого впливу) діагностичного параметру окремих функціональних вузлів. Проаналізовано умови розповсюдження тепла в ізолюючому шарі напівпровідникової структури, яка містить в собі декілька окремих функціональних вузлів з відомим геометричним місцем розташування на підложці.
Дослідження спрямовані на вирішення задач технічного діагностування, а саме: визначення фактичного технічного стану цифрового радіоелектронного обладнання та прогнозування технічного стану.
Using Unnatural Protein Fusions to Engineer a Coenzyme Self-Sufficiency System for D-Phenyllactic Acid Biosynthesis in Escherichia coli
Authors: Qin Zhao , Wang Dan , Luo Ruoshi , Li Tinglan , Xiong Xiaochao , Chen Peng 
Published: December 2021

The biosynthetic production of D-penyllactic acid (D-PLA) is often affected by insufficient supply and regeneration of cofactors, leading to high production cost, and difficulty in industrialization. In this study, a D-lactate dehydrogenase (D-LDH) and glycerol dehydrogenase (GlyDH) co-expression system was constructed to achieve coenzyme NADH self-sufficiency and sustainable production of D-PLA. Using glycerol and sodium phenylpyruvate (PPA) as co-substrate, the E. coli BL21 (DE3) harboring a plasmid to co-express LfD-LDH and BmGlyDH produced 3.95 g/L D-PLA with a yield of 0.78 g/g PPA, similar to previous studies. Then, flexible linkers were used to construct fusion proteins composing of D-LDH and GlyDH. Under the optimal conditions, 5.87 g/L D-PLA was produced by expressing LfD-LDH-l3-BmGlyDH with a yield of 0.97 g/g PPA, which was 59.3% increased compared to expression of LfD-LDH. In a scaled-up reaction, a productivity of 5.83 g/L/h was reached. In this study, improving the bio-catalytic efficiency by artificial redox self-equilibrium system with a bifunctional fusion protein could reduce the bio-production cost of D-PLA, making this bio-production of D-PLA a more promising industrial technology.
Characterization of the Microflow Through 3D Synthetic Niche Microenvironments Hosted in a Millifluidic Bioreactor
Authors: Ene-Iordache Bogdan , Campiglio Chiara Emma , Raimondi Manuela Teresa , Remuzzi Andrea 
Published: December 2021

Background: Development of new medicines is a lengthy process with high risk of failure since drug efficacy measured in vitro is difficult to confirm in vivo. Intended to add a new tool aiding drug discovery, the MOAB-NICHOID device was developed: a miniaturized optically accessible bioreactor (MOAB) housing the 3D engineered scaffold NICHOID. The aim of our study was to characterize the microflow through the 3D nichoid microenvironment hosted in the MOAB-NICHOID device.Methods: We used computational fluid dynamics (CFD) simulations to compute the flow field inside a very fine grid resembling the scaffold microenvironment.Results: The microflow inside the multi-array of nichoid blocks is fed and locally influenced by the mainstream flow developed in the perfusion chamber of the device. Here we have revealed a low velocity, complex flow field with secondary, backward, or local recirculation micro-flows induced by the intricate architecture of the nichoid scaffold.Conclusion: Knowledge of the microenvironment inside the 3D nichoids allows planning of cell experiments, to regulate the transport of cells towards the scaffold substrate during seeding or the spatial delivery of nutrients and oxygen which affects cell growth and viability.
Spectral, Anti-Inflammatory, Anti-Pyretic, Leishmanicidal, and Molecular Docking Studies, Against Selected Protein Targets, of a New Bisbenzylisoquinoline Alkaloid
Authors: Alamzeb Muhammad , Setzer William N. , Ali Saqib , Khan Behramand , Rashid Mamoon-Ur- , Ihsanullah  , Salman Syed Muhammad , Adnan  , Omer Muhammad , Ali Javed , Ullah Asad 
Published: December 2021

A new bisbenzylisoquinoline named as chondrofolinol (1) and four reported compounds (2–5) were isolated and characterized from the roots of Berberis glaucocarpa Stapf. Anti-inflammatory, anti-pyretic, and leishmanicidal studies were performed against carrageenan-induced paw edema, yeast-induced pyrexia, and the promastigotes of Leishmania tropica, respectively. The new compound significantly reduced the paw volume in carrageenan-induced paw edema and rectal temperature in yeast-induced pyrexia at 10 and 20 mg/ kg of body weight. Chondrofolinol caused almost 100% inhibition of the promastigotes of Leishmania tropica. All the compounds displayed minimal cytotoxicity against THP-1 monocytic cells. In order to ascertain the potential macromolecular targets of chondrofolinol responsible for the observed anti-inflammatory and anti-leishmanial activities, a molecular docking study was carried out on relevant protein targets of inflammation and Leishmania. Protein targets of human endoplasmic reticulum aminopeptidase 2 (ERAP2) and human matrix metalloproteinase-1 (MMP-1) for inflammation and protein targets of N-myristoyltransferase (NMT), tyrosyl-tRNA synthetase (TyrRS), and uridine diphosphate-glucose pyrophosphorylase (UGPase) for Leishmania major were selected after thorough literature search about protein targets responsible for inflammation and Leishmania major. Chondrofolinol showed excellent docking to ERAP2 and to MMP-1. The Leishmania major protein targets with the most favorable docking scores to chondrofolinol were NMT, TyrRS, and UGPase. The study indicated that bisbenzylisoquinoline and isoquinoline alkaloids possess anti-pyretic, anti-inflammatory, and anti-leishmanial properties with minimal cytotoxicity and therefore, need to be further explored for their therapeutic potential.
Long-Term Outcomes of Bioprosthetic or Mechanical Valve Replacement in End-Stage Renal Disease: A Nationwide Population-Based Retrospective Study
Authors: Li Guan-Yi , Chen Yun-Yu , Chung Fa-Po , Chien Kuo-Liong , Hsu Chiao-Po , Lin Yenn-Jiang 
Published: December 2021

Background: Valve replacement is associated with worse outcomes in individuals who have end-stage renal disease (ESRD) and require a long-term renal replacement therapy. Prosthetic valve selection in patients with ESRD has remained controversial.Objective: We aimed to investigate long-term outcomes of mechanical and bioprosthetic valve replacement in individuals with ESRD.Methods: We conducted a population-based retrospective cohort study using data obtained from the Taiwan National Health Insurance Research Database. In total, 10,202 patients, including 912 ESRD and 9,290 non-ESRD patients, were selected after a 1:1 propensity-score matching based on the type of prosthetic valve used. The long-term mortality outcomes were then analyzed.Results: During a median follow-up period of 59.6 months, the Kaplan–Meier survival analysis revealed that ESRD patients who underwent mechanical valve replacement had higher rates of all-cause mortality and CV deaths than those who underwent bioprosthetic valve replacement (Log-rank test, p = 0.03 and 0.02, respectively). Multivariable regression analyses demonstrated that ESRD patients who underwent bioprosthetic valve replacement had lower rates of all-cause mortality (p &lt; 0.001, hazard ratio: 0.88, 95% confidence interval: 0.82–0.93) and cardiovascular (CV) death (p &lt; 0.001, hazard ratio: 0.83, 95% confidence interval: 0.76–0.90) than those who had mechanical valve replacement.Conclusion: Bioprosthetic valve replacement is significantly associated with lower rates of all-cause mortality and CV death in the ESRD population.
Mendelian Randomization Integrating GWAS, eQTL, and mQTL Data Identified Genes Pleiotropically Associated With Atrial Fibrillation
Authors: Liu Yaozhong , Li Biao , Ma Yingxu , Huang Yunying , Ouyang Feifan , Liu Qiming 
Published: December 2021

Background: Atrial fibrillation (AF) is the most common arrhythmia. Genome-wide association studies (GWAS) have identified more than 100 loci associated with AF, but the underlying biological interpretation remains largely unknown. The goal of this study is to identify gene expression and DNA methylation (DNAm) that are pleiotropically or potentially causally associated with AF, and to integrate results from transcriptome and methylome.Methods: We used the summary data-based Mendelian randomization (SMR) to integrate GWAS with expression quantitative trait loci (eQTL) studies and methylation quantitative trait loci (mQTL) studies. The HEIDI (heterogeneity in dependent instruments) test was introduced to test against the null hypothesis that there is a single causal variant underlying the association.Results: We prioritized 22 genes by eQTL analysis and 50 genes by mQTL analysis that passed the SMR &amp; HEIDI test. Among them, 6 genes were overlapped. By incorporating consistent SMR associations between DNAm and AF, between gene expression and AF, and between DNAm and gene expression, we identified several mediation models at which a genetic variant exerted an effect on AF by altering the DNAm level, which regulated the expression level of a functional gene. One example was the genetic variant-cg18693985-CPEB4-AF axis.Conclusion: In conclusion, our integrative analysis identified multiple genes and DNAm sites that had potentially causal effects on AF. We also pinpointed plausible mechanisms in which the effect of a genetic variant on AF was mediated by genetic regulation of transcription through DNAm. Further experimental validation is necessary to translate the identified genes and possible mechanisms into clinical practice.
Hydrochemical and Hydroacoustic Investigation of the Yugama Acid Crater Lake, Kusatsu-Shirane, Japan
Authors: Hernández Pedro A. , Nogami Kenji , Padrón Eleazar , Somoza Luis , Amonte Cecilia , Mori Toshiya , Melián Gladys V. , Sumino Hirochicka , Kikawada Yoshikazu , Pérez Nemesio M. 
Published: December 2021

The gases dissolved in the waters of volcanic lakes can present a serious hazard if the physical-chemical conditions change due to variations in the supply of magmatic gases. The monitoring of gases such as CO2 and He help us understand the degassing process and their connection with magmatic/hydrothermal system. One of the most acidic volcanic lakes on the planet is the Yugama, on Kusatsu Shirane volcano (Japan). We report the results of an interdisciplinary study carried out in August 2013 at Yugama consisting of the first estimation of rate of diffuse CO2 emission, the chemical and isotopic analysis of water and dissolved gases in samples from vertical lake profiles, and an echo-sounding survey. The lake water has an average temperature of 24-25°C, pH 1.01, concentrations of SO42- between 1,227 and 1,654 mgL−1 and Cl− between 1,506 and 2,562 mgL−1, with gas bubbling at several locations and floating sulfur globules with sulfide inclusions. A total of 66 CO2 efflux measurements were taken at the lake surface by means of the floating accumulation chamber method to estimate the diffuse CO2 output from the studied area. CO2 efflux values ranged from 82 up to 25,800 g m−2 d−1. Estimation of the diffuse CO2 emission at Yaguma Crater Lake was 30 ± 12 t d−1. Normalized CO2 emission rate (assuming an area of 0.066 km2) was 454 t km−2 d−1, a value within the range of acid volcanic lakes. Vertical profiles of major ions and dissolved gases showed variations with increases in ion content and dissolved CO2 and He with depth. Acoustic imaging shows the presence of intense bubbling and provides important information on the bathymetry of the lake. The 50–200 kHz echograms exhibit frequent vertical plumes of rising gas bubbles. Within the crater-lake, three circular submarine vents have been identified showing flares due to a significant activity of sublacustrine emissions. This work shows the first data of diffuse CO2 degassing, dissolved gases in water and echosounding (ES) from Yugama Crater Lake. Periodic hydrogeochemical and hydroacoustic surveys at Yugama Crater Lakemay thus help to document changes in the state of activity of this high-risk volcanic area.
Coseismic Stability Assessment of a Damaged Underground Ammunition Storage Chamber Through Ambient Vibration Recordings and Numerical Modelling
Authors: Glueer Franziska , Häusler Mauro , Gischig Valentin , Fäh Donat 
Published: December 2021

In the past decade, ambient vibration measurements found numerous applications on unstable rock slopes and developed into a powerful tool for site characterization of slope instabilities. In this study, for the first time ambient vibration measurements were applied to a rock mass strongly disturbed and damaged by subsurface explosions. The site above the ammunition storage chamber at Mitholz (Switzerland) is especially interesting because the subsurface geology below the seismic array is well known, including the location of the caverns, and the degree of degradation caused by the subsurface explosions in 1947 of around 40 t TNT of ammunition. Measurement data were analyzed using current state-of-the-art seismic single-station and array methods, focusing on surface-wave dispersion analysis, wave field polarization, wave amplification using site-to-reference spectral ratios and analysis of normal mode behavior. The results allow for calibrating the elastic properties of a 2D numerical rock mechanical model which was used to simulate the stability of the disturbed rock mass during seismic loading. Therefore, ambient vibration measurements can contribute not only to a better understanding of the subsurface, but also for the assessment of earthquake risk.
Isolation and Characterization of Bacillus Sp. Capable of Degradating Alkali Lignin
Authors: Yang Jing , Zhao Jian , Jiang Jianchun , Xu Hao , Zhang Ning , Xie Jingcong , Wei Min 
Published: December 2021

Alkali lignin-degrading Bacillus were isolated from forest soils in China and were identified as Bacillus subtilis TR-03 and Bacillus cereus TR-25 by 16S rDNA sequence analysis. Wherein TR-03 displayed optimal 26.72% alkali lignin (2 g/L) degradation at 7 days and 71.23% of Azure-B (0.01%) decolorization at 36 h of cultivation at 37°C. Ligninolytic enzyme analysis revealed that TR-03 was capable of depolymerizing alkali lignin effectively by the producing of lignin peroxidase and laccase, wherein higher laccase activity was cell-associated. At last, the physical and chemical changes of lignin via SEM and FTIR analysis was further observed to prove the lignin degradation by Bacillus subtilis TR-03.
Microplastic in Water and Sediments at the Confluence of the Elbe and Mulde Rivers in Germany
Authors: Laermanns Hannes , Reifferscheid Georg , Kruse Jonas , Földi Corinna , Dierkes Georg , Schaefer Dirk , Scherer Christian , Bogner Christina , Stock Friederike 
Published: December 2021

Accumulation of microplastics in aquatic environments is an issue of emerging concern. Initially, research focused on marine systems. However, recent studies also investigate the abundance of microplastics in freshwater environments. Rivers connect terrestrial with marine ecosystems and contribute a considerable share of macro- and microplastics to the oceans. A previous study found a large amount of micro-spheres in Dessau downstream the river mouth of the Mulde. Therefore, the objective of this research was to examine whether the Mulde river with its highly industrialized catchment contributes to the microplastic pollution of the Elbe. Sediment (Van Veen grab sampler) and water samples (filter cascade with the smallest mesh size 50 μm and nets with the smallest mesh size 150 μm) were taken from the Elbe river up- and downstream the confluence with the Mulde. After extensive sample preparation, we examined the samples under a digital microscope and determined polymer types by pyrolysis Gas Chromatography/Mass Spectrometry (pyr-GC-MS). The amount of primary microplastics increased in sediment and water samples just downstream the confluence. Those microplastics originate probably from the Mulde. We measured larger amounts and different shapes of microplastics in filter cascades that have a smaller mesh size compared to the nets.