bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oxytocin signal contributes to the adaptative growth of islets during gestation
Authors: Gu Ping , Lin Yuege , Wan Qi , Su Dongming , Shu Qun 
Published: June 2021

Background
Increased insulin production and secretion by pancreatic β-cells are important for ensuring the high insulin demand during gestation. However, the underlying mechanism of β-cell adaptation during gestation or gestational diabetes mellitus (GDM) remains unclear. Oxytocin is an important physiological hormone in gestation and delivery, and it also contributes to the maintenance of β-cell function. The aim of this study was to investigate the role of oxytocin in β-cell adaptation during pregnancy.

Methods
The relationship between the blood oxytocin level and pancreatic β-cell function in patients with GDM and healthy pregnant women was investigated. Gestating and non-gestating mice were used to evaluate the in vivo effect of oxytocin signal on β-cells during pregnancy. In vitro experiments were performed on INS-1 insulinoma cells.

Results
The blood oxytocin levels were lower in patients with GDM than in healthy pregnant women and were associated with impaired pancreatic β-cell function. Acute administration of oxytocin increased insulin secretion in both gestating and non-gestating mice. A 3-week oxytocin treatment promoted the proliferation of pancreatic β-cells and increased the β-cell mass in gestating but not non-gestating mice. Antagonism of oxytocin receptors by atosiban impaired insulin secretion and induced GDM in gestating but not non-gestating mice. Oxytocin enhanced glucose-stimulated insulin secretion, activated the mitogen-activated protein kinase pathway, and promoted cell proliferation in INS-1 cells.

Conclusions
These findings provide strong evidence that oxytocin is needed for β-cell adaptation during pregnancy to maintain β-cell function, and the lack of oxytocin could be associated with the risk of GDM.
Texture analysis of orbital magnetic resonance imaging for monitoring and predicting treatment response to glucocorticoids in patients with thyroid-associated ophthalmopathy
Authors: Wang Yue-Yue , Wu Qian , Chen Lu , Chen Wen , Yang Tao , Xu Xiao-Quan , Wu Fei-Yun , Hu Hao , Chen Huan-Huan 
Published: June 2021

Purpose
To evaluate the value of MRI-based texture analysis of extraocular muscle (EOM) and orbital fat (OF) in monitoring and predicting the response to glucocorticoid (GC) therapy in patients with thyroid-associated ophthalmopathy (TAO).

Methods
Thirty-seven active and moderate-to-severe TAO patients (responders, n = 23; unresponders, n = 14) were retrospectively enrolled. MRI-based texture parameters (entropy, uniformity, skewness and kurtosis) of EOM and OF were measured before and after GC therapy, and compared between groups. Correlations between the changes of clinical activity score (CAS) and imaging parameters before and after treatment were assessed. Receiver operating characteristic curves were used to evaluate the predictive value of identified variables.

Results
Responsive TAOs showed significantly decreased entropy and increased uniformity at EOM and OF after GC therapy (P < 0.01), while unresponders showed no significance. Changes of entropy and uniformity at EOM and OF were significantly correlated with changes of CAS before and after treatment (P < 0.05). Responders showed significantly lower entropy and higher uniformity at EOM than unresponders before treatment (P < 0.01). Entropy and uniformity of EOM and disease duration were identified as independent predictors for responsive TAOs. Combination of all three variables demonstrated optimal efficiency (area under curve, 0.802) and sensitivity (82.6%), and disease duration alone demonstrated optimal specificity (100%) for predicting responsive TAOs.

Conclusion
MRI-based texture analysis can reflect histopathological heterogeneity of orbital tissues. It could be useful for monitoring and predicting the response to GC in TAO patients.
Walking Many Paths, Our Research Journey to (Re)present Multiple Knowings
Authors: Hogarth Melitta , Czuy Kori 
Published: June 2021

Indigenous peoples globally are seeking new ways in which to communicate and share our worldviews. Sometimes defined as resistance research, emancipatory research, decolonising research - our research (re)presents the multiple journeys in which we live and come to know. Emerging Indigenous research methodological approaches are centring Indigenous ways of knowing, being and doing, to privilege Indigenous voices that have been suppressed through colonization. The intricate weaving of Western methodologies with Indigenous knowledges evokes agency in two emerging Indigenous researchers (from Australia and Canada) and weaves a path of reconciliation between their diverse disciplines as well as the seemingly dichotomous knowledge systems they are challenged to work within. Using metalogue, a way of authentically bringing together multiple voices through dialogue, we discuss the creative and radical Indigenous methodological approaches developed and enacted within our PhDs. The paper will provide insights to the epistemological, ontological and axiological principles that inform emerging Indigenous approaches to research.
How does didactic knowledge develop?: Experiences from a design project
Authors: Sloane Peter F. E. 
Published: June 2021

We, the authors of the paper, have jointly conducted several design-based research (DBR) projects. The subject of this paper is a project lasting approximately 18 months, which dealt with the introduction of a new curriculum in a vocational college. We were involved in different roles: one as a representative of the research community and the other as a representative of the vocational college and thus of practice. In the project, different interests were considered: the research division wanted to generate knowledge while the practitioners were interested in implementing a curriculum and developing new forms of learning and teaching. It is not that we could always assign each of these two perspectives to exactly one of us, even though we were officially researchers and practitioners. We have always approached each other in our DBR projects.
Both perspectives have been incorporated into the paper: One author is concerned with the genesis of knowledge—how knowledge is created in DBR projects, a partly methodological approach. The other author attempts to find theoretical points of reference and reassurances about the project work. This leads to very practical considerations.
The project did not commence with an exactly defined problem; we began with broad concerns that had to be distilled into specific goals over the course of the project..
We had to conduct dialogical planning in our different roles and responsibilities. After each work phase and workshop, we reviewed and made a record of what had happened and how, the condition of the group and what it should work on in the next practical phase. This was supplemented with classroom visits and one-on-one discussions with various project participants. The information derived from these evaluations was subsequently used in the planning of the next cycle. Therefore, in the next cycle, the same project was not conducted, but a revised project was developed, which continued from where the previous cycle had ended. Thus, the problem definition continued evolving. In this paper, we have tried to concisely present how the work progressed in phases and cycles and roughly described the thought process and evaluations that shaped this project. Perceived this way, this paper serves two different interests. First, it shows how a problem definition was developed and further sharpened and what concrete result was obtained in the process. This is indicated by the subtitle. Second, it explains how knowledge is created and defines the scope and specificity of this knowledge.
Assessment of reinforced concrete slab of historical structures by the yield-line method
Authors: Mahrouseh Rayan , Orbán Zoltán 
Published: June 2021

AbstractThe study demonstrates and evaluates an approach in the structural analysis phase when assessing reinforced concrete slabs.Due to different values of a parameter in the tests’ results, 10 models was crated for the first case study and 4 models for the second one.In order to compare the results in terms of the flexural bearing capacity, the slabs were analyzed by using elastic finite element analysis and yield-line analysis.Comparing the results shows that minor modification in the parameters associated with bearing capacity and the boundary conditions can affect the adequacy factor considerably, while the parameters those relate to boundary conditions affect the distribution of the yield lines.
Vehicle occupant safety development with finite element method
Authors: Porkolab Laszlo , Lakatos Istvan 
Published: June 2021

AbstractCrash tests of vehicles are specified by government programs. This laws are includes only minimum requirements for individual components. Therefore additional consumer protection load cases have been developed by independent private institutes. Finite element method simulations can reduce development periods and the number of cost-intensive real crash tests. The goals of the calculations are that the early detection of component failure, the protection of occupants or pedestrians. The biggest challenge of the future, in the field of vehicle occupant safety is the interaction of the airbags and belt system with dummy by the electric vehicles, which have the concept of autonomous driving function. The aim of the research is to investigate this area using a simulation model.
In Silico Activity Identification of Cyclo Peptide Alkaloids from Zizyphus Spina-Christi Species Against Sars-Cov-2 Main Protease
Authors: Fakih Taufik Muhammad , Ramadhan Dwi Syah Fitra , Darusman Fitrianti 
Published: June 2021

The COVID-19 has spread worldwide and become an international pandemic. The promising target for drug discovery of COVID-19 was SARS-CoV-2 Main Protease (Mpro), that has been successfully crystallized along with its inhibitor. The discovery of peptide-based inhibitors may present better options than small molecules for inhibitor SARS-CoV-2 Mpro. Natural compounds have such a wide potential and still few explored, Zizyphus spina-christi is one of the medicinal plants that have many pharmacological activities and contains a peptide compound from alkaloids class, i.e. cyclopeptide alkaloids, that is interesting to explore as SARS-CoV-2 Mpro inhibitor. The compound structure was drawn and optimized using density functional theory 3-21G method. The protein chosen was the high resolution of SARS-CoV-2 MPro receptor (1.45 Å) with PDB ID: 6WNP, in complex with boceprevir. Molecular docking simulation was performed using Autodock4 with 100 numbers of GA run, the validation methods assessed by RMSD calculation. Furthermore, the prediction of pharmacological activity spectra was carried out using the PASS Prediction server. The results showed RMSD value was 1.98 Å, this docking method was valid. The binding energy of all compounds showed better results than the native ligand (Boceprevir). The in silico PASS prediction results indicated that all compounds showed antiviral activity. Some compounds showed protease inhibitory activity, i.e Ambiphibine-H, Franganine, and Mauritine-A, and the highest Pa (Predicted activity) value showed by Mauritine-A compounds. It can be concluded that the cyclopeptide compounds of Zizyphus spina-christi were indicated to have a potential as COVID-19 therapy targeting SARS-CoV-2 Mpro.
Implementasi Manajemen Program Gerakan Literasi Madrasah di MAN 1 Lamongan
Authors: Barokah Saida Rifda , Bentari Yensika Yosi 
Published: June 2021

Penelitian ini bertujuan untuk mendeskripsikan implementasi menejemen program Gerakan Literasi Madrasah, menjelaskan tahap-tahap pelaksanaan program Gerakan Literasi Madrasah, menjelaskan kelebihan dan kekurangan dari program Gerakan Literasi Madrasah di MAN 1 Lamongan. Teknik pengumpulan data yang digunakan adalah wawancara, observasi, dan dokumentasi. Keabsahan data menggunakan triangulasi sumber dan teknik. Teknik analisis data menggunakan teknik analisis Miles dan Huberman meliputi reduksi data, menyajikan data, dan menarik kesimpulan. Hasil pembahasan implementasi menejemn program Gerakan Literasi Madrasah di MAN 1 Lamongan yang dilaksanakan sesuai dengan fungsi menejemn meliputi perencanaan pengorganisasian , pelaksanaan dan evaluasi. Perencanaan yang terlaksana dengan menetapkan visi, misi, dan tujuan program Gerakan Literasi Madrasah. Pengorganisasian yang memberi tanggung dan pembagian tugas pada penanggung jawab, pelakasanaan yang dilakukan sesuai dengan apa yang telah direncanakan, dan evaluasi yang mana mengkontrol semua aktivitas yang terlaksana. Dan dalam penelitian ini juga menjelaskan tentang kelebihan dan kekurangan dalam Program Gerakan Literasi Madrasah di MAN 1 Lamongan.
Pengelolaan Pencairan BOP melalui Pendataan TPQ pada EMIS di Kantor Kementerian Agama Kota Mojokerto
Authors: Wulandary Innanda Oqta Putri , Rosyidah Dyana Maftuhatu , Muzakki Hamid , Mukhlishah Mukhlishah 
Published: June 2021

Pelaksanaan penelitian ini bertujuan untuk mengetahui proses pengelolaan pencairan biaya operasional (BOP) melalui pendataan Taman Pendidikan Al-Qur’an (TPQ) Pada Education Manajemen Information System (EMIS) di Kantor Kementerian Agama Kota Mojokerto. Penelitian ini dilaksanakan dengan menggunakan metode deskriptif kualitatif. Subyek dari penelitian ini adalah bagian administrasi dibidang Pendidikan Agama dan Keagamaan Islam (PAKIS) yang mengurusi EMIS PONTREN, Setelah dilakukan penelitian melalui teknik pengumpulan data menggunakan wawancara, observasi dan dokumentasi, dapat disimpulkan bahwa pendataan berjalan dengan kurang maksimal. Terdapat beberapa kendala yang dialami oleh bagian administrasi PAKIS, kendala tersebut berasal dari Sumberdaya Manusia, Jaringan dan server yang kurang stabil, serta menu dari aplikasi EMIS yang kurang lengkap, semua kendala tersebut perlu diatasi dengan pembuatan link khusus atau group Whatsapp pengisian data TPQ oleh pihak administrasi PAKIS Kementerian Agama Kota Mojokerto, dengan adanya link khusus atau group Whatsapp tersebut, maka pengisian data dapat berjalan dengan lebih efektif dan efisien, untuk selanjutnya data tersebut diolah dalam aplikasi EMIS dan digunakan untuk syarat pencaitan dana BOP bagi TPQ di wilayah Kota Mojokerto.
Implementasi Beban Kerja dan Kuantitas Karyawan terhadap Kinerja Karyawan Pendma di Kantor Kementerian Agama Kabupaten Bangkalan
Authors: Syafitri Ananda Devia Ayu , Ubudiyah Kamilatul , Fatoni Moh. Azmi , Bachtiyar Machfud 
Published: June 2021

Penelitian ini bertujuan untuk mengetahui: (1) beban kerja, kuantitas karyawan dan kinerja karyawan (2) besarnya beban kerja, kuantitas karyawan terhadap kinerja pegawai. Penelitian ini dilakukan pada kantor Kementerian Agama Kabupaten Bangkalan khusunya pada bidang Pendidikan Madrasah (PENDMA), subjek penelitian yang digunakan adalah seluruh karyawan yang ada di bidang Pendidikan Madrasah (PENDMA) Kantor Kementerian Agama Kabupaten Bangkalan. Jenis penelitian yang digunakan adalah deskriptif dengan pendekatan kualitatif, sedangkan teknik pengumpulan data yang digunakan yaitu dengan observasi dan wawancara.Sedangkan untuk analisis data, peneliti berupaya untuk menggabungkan seluruh data yang didapat dengan teori yang ada. Hasil penelitian menunjukkan bahwa beban kerja yang berpengaruh negatif bagi kantor diantaranya kurangnya karyawan di kantor, perencanaan tenaga kerja yang kurang baik, memberikan pekerjaan secara berlebihan terhadap karyawan, dan buruknya pengelolaan SDM.
REST and Stress Resistance in the Aging Kidney
Authors: Magassa Sato , Aron Liviu , Hoguin Clément , Isnard Pierre , Terzi Fabiola , Legendre Christophe , Yankner Bruce A. , Canaud Guillaume 
Published: June 2021

Significance Statement
Aging slowly alters kidney function, with progressive nephron reduction leading to metabolic and mechanical constraints for the remaining nephrons. Podocytes, due to their anatomic location, are particularly exposed to aging-related stress. Knowledge of biological mechanisms behind podocyte adaptation is limited. We identified REST, a repressor of neuronal genes, as a key player in nephron adaptation to aging. Innovative tools demonstrate that REST acts on the podocyte cytoskeleton, promoting resistance to mechanical stressors, and that REST regulates podocyte survival. Finally, REST expression is upregulated in human podocytes during aging, consistent with a conserved mechanism of stress resistance. This study suggests REST protects the kidney from injury and degeneration during aging, with potentially important therapeutic implications.

Background
CKD is associated with the loss of functional nephr ons, leading to increased mechanical and metabolic stress in the remaining cells, particularly for cells constituting the filtration barrier, such as podocytes. The failure of podocytes to mount an adequate stress response can lead to further nephron loss and disease progression. However, the mechanisms that regulate this degenerative process in the kidney are unknown.

Methods
We combined in vitro, in vivo, and organ-on-chip approaches to identify the RE1-silencing transcription factor (REST), a repressor of neuronal genes during embryonic development, as a central regulator of podocyte adaptation to injury and aging.

Results
Mice with a specific deletion of REST in podocytes exhibit albuminuria, podocyte apoptosis, and glomerulosclerosis during aging, and exhibit increased vulnerability to renal injury. This phenotype is mediated, in part, by the effects of REST on the podocyte cytoskeleton that promote resistance to mechanical stressors and augment podocyte survival. Finally, REST expression is upregulated in human podocytes during aging, consistent with a conserved mechanism of stress resistance.

Conclusions
These results suggest REST protects the kidney from injury and degeneration during aging, with potentially important therapeutic implications.
Mapeo de cobertura terrestre utilizando aprendizaje máquina
Authors: Muñoz-Ordóñez Cristian , Muñoz-Ordóñez Julián , Pencue-Fierro Leonairo , Figueroa Apolinar 
Published: June 2021

Objetivo: Determinar las dinámicas de evolución de la cobertura terrestre sobre la Cuenca Alta del Río Cauca. Metodología: Esta investigación, presenta un proceso de clasificación de coberturas sobre la CARC utilizando imágenes Landsat-8 y Sentinel-1. Este análisis se realizó mediante la clasificación de características de imágenes satelitales ópticas y de radar, utilizando algoritmos de aprendizaje máquina. Resultados y conclusiones: se identificaron regiones que presentan afectación en sus coberturas vegetales mostrando la importancia de la utilización conjugada de satélites ópticos y de radar. La clasificación tuvo una precisión del 88.9% y un coeficiente kappa de 0.86
Sistema de medición y control de temperatura para un prototipo de planta de tratamiento de aguas residuales
Authors: Ramírez Jiménez Diego Fermando 
Published: June 2021

Objetivo: Diseñar e implementar un sistema de medición y control de temperatura para un prototipo de planta de tratamiento de aguas residuales a escala de laboratorio. Metodología: El trabajo realizado consistió en la implementación a escala de laboratorio de una planta de tratamiento de aguas residuales, la cual efectuó la etapa de tratamiento secundario del afluente disponible a través de un proceso biológico de lodos activados. Resultados: El control de temperatura diseñado e implementado permitió garantizar condiciones adecuadas de homeostasis a los microorganismos encargados del tratamiento de agua residual. Lo anterior, se verificó a través de pruebas fisicoquímicas realizadas al efluente obtenido luego de ser tratado. Conclusiones: El prototipo implementado logró un efluente con mejoras del 67% aproximadamente en componentes como el DBO y del 84% en sólidos suspendidos, lo cual es significativo para el trabajo realizado, pero no es suficiente para que pueda ser destinado al consumo humano.
Prospects and Challenges of Afan Oromo: A Commentary
Authors: Walga Tamene Keneni 
Published: June 2021

Afan Oromo- the language of the Oromo- is also known as Oromo. The word ‘Oromo’ refers to both the People of Oromo and their language. It is one of the widely spoken indigenous African languages. It is also spoken in multiple countries in Africa including Ethiopia, Kenya, Somalia, Sudan and Tanzania among others. Moreover, it is spoken as a native language, second language and lingua-franca across Ethiopia and beyond. Regardless of its scope in terms of number of speakers and geographical area it covers, Afan Oromo as a literary language is only emerging due to perpetuating unfair treatment it received from successive Ethiopian regimes. This commentary sought to examine prospects and challenges of Afan Oromo. To this end, drawing on existing literature and author’s own personal observations, salient prospects and challenges of Afan Oromo have been presented and briefly discussed. Suggestions to confront the challenges foreseen have been proposed by the author where deemed necessary. The paper concludes with author’s concluding remarks concerning the way forward.
Site-Response Analysis Using the Shear-Wave Velocity Profile Correction Approach
Authors: Williams Tessa , Abrahamson Norman 
Published: June 2021

ABSTRACT
The traditional approach used to incorporate site response into the ground-motion hazard analysis is to compute a design spectrum for a rock-site condition and then propagate the rock motion from the base of the soil model to the surface. The main limitation with this approach is that it can be inconsistent with the ground-motion models (GMMs) used to develop the input rock motion. The VS profile implicit in the GMMs is unlikely to match the site-specific VS profile (value and gradient), because the GMMs were developed for ground motions from different VS profiles over large regions and are unlikely to match the profile of any one site well. This article presents the VS profile correction method for developing surface ground motions as an alternative to the soil-over-rock approach routinely used in earthquake engineering practice. This approach is similar to the standard soil-over-rock analysis, but uses different input motions and involves performing two site response analyses—one for the generic profile associated with the GMM(s) and one for the site-specific profile—then applying the ratio of the two site response analysis results to correct the design spectrum for the reference site condition developed using the GMMs. Two example applications are included to illustrate the VS profile correction methodology as well as some of the challenges that may arise when doing so.