bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Therapeutic Efficacy of Debulking Plus Drug-coated Balloon Angioplasty Versus Drug-coated Balloon Angioplasty Alone for Femoropopliteal Tosaka Class Iii in-stent Restenosis Lesions
Authors: Li Liqiang , Tong Zhu , Cui Shijun , Guo Lianrui , Gu Yongquan 
Published: December 2021

Abstract
Background: Femoropopliteal (FP) Tosaka Class III in-stent restenosis (ISR) Lesions remain a significant clinical problem and optimal revascularization management including the use of drug-coated balloon (DCB) and debulking devices have the potential to improve the outcomes for these patients. However, few studies have been published comparing the debulking plus DCB with DCB alone in Tosaka III FP-ISR treatment. This study was to compare debulking plus DCB versus DCB alone for the treatment of Tosaka III FP-ISR lesions in patients.Methods: This was a single-center retrospective study of patients Tosaka III FP-ISR who underwent endovascular interventions of debulking plus DCB or DCB alone for Tosaka III FP-ISR lesions. One-year primary patency was the main outcome. Other outcome measures are 12-month freedom from clinical-driven target lesion revascularization (f-CD-TLR), technical success rate, and periprocedural complications.Results: A total of 70 patients with Tosaka III FP-ISR were included; 29 were treated with debulking plus DCB, in which 13 were treated with laser atherectomy (LA) plus DCB and 16 were treated with rotational atherectomy (RA) plus DCB. 41 were treated with DCB alone. Lesions in the debulking plus DCB group were significantly longer (16.45±4.40mm vs. 14.04±3.67mm, p=0.015). the 12-month primary patency was not significant different in the comparison of debulking+DCB with DCB group (75.9% vs. 73.2%, p=0.798). in the subgroup comparison, no significant difference was found in the LA+DCB and RA+DCB group (69.2% vs. 81.3%, p=0.544). There were also no significant differences in the group and subgroup comparison of 12-month f-CD-TLR, technical success rate, and periprocedural complications.Conclusions: Debulking plus DCB or DCB alone are both safe and effective for Tosaka III FP-ISR lesions. Although no significant difference was seen, lesions in the debulking+DCB group were significantly longer, suggesting that debulking plus DCB treatment has possible superiority for longer lesions than DCB alone management.
Assessing the Co-Movements between Electricity Use and Carbon Emissions in the GCC area: Evidence from a Wavelet Coherence Method
Authors: Matar Ali , Fareed Zeeshan , Magazzino Cosimo , Al-Rdaydeh Mahmoud , Schneider Nicolas 
Published: December 2021

Abstract
This paper investigates the association between CO2 emissions and a range of factors, including electricity consumption, economic growth, urbanization, and trade openness for six Gulf Cooperation Council (GCC) countries using data covering the 1965-2019 period. Namely, Oman, Saudi Arabia, the UAE, Kuwait, Bahrain, and Qatar. Contrasting with the standard literature, our empirical strategy uses the wavelet coherence approach on the frequency domain, thought to complement the time-series econometric procedures reported on this topic. Supplied at the country-level, associated evidence presents far-reaching policy recommendations whose applications may directly benefit environmental planning and bring high information value for the sake of sustainable energies in the Gulf region.JEL: Q43, C22, C23, E20, O44.
Endogenous Retrovirus-Derived lnc-ALVE1-AS1 Exerts Antiviral Defense Against ALV-J Infection in Chicken Macrophages
Authors: Luo Huan , Hu Xuming , Wu Huixian , Zaib Gul , Chai Wenxian , Cui Hengmi 
Published: December 2021

Abstract
Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections dating back many millions of years, and their derived transcripts with viral signatures are important sources of long noncoding RNAs (lncRNAs). We have previously shown that the chicken ERV-derived lncRNA lnc-ALVE1-AS1 exerts antiviral innate immunity in chicken embryo fibroblasts. However, it is not clear whether this endogenous retroviral RNA has a similar function in immune cells. Here, we found that lnc-ALVE1-AS1 was persistently inhibited in chicken macrophages after avian leukosis virus subgroup J (ALV-J) infection. Furthermore, overexpression of lnc-ALVE1-AS1 significantly inhibited the proliferation of exogenous ALV-J, whereas knockdown of lnc-ALVE1-AS1 promoted the proliferation of ALV-J in chicken macrophages. This phenomenon is attributed to the induction of antiviral innate immunity by lnc-ALVE1-AS1 in macrophages, whereas knockdown of lnc-ALVE1-AS1 had the opposite effect. Mechanistically, lnc-ALVE1-AS1 can be sensed by the cytosolic pattern recognition receptor TLR3 and trigger the type I interferons response. The present study provides novel insights into the antiviral defense of ERV-derived lncRNAs in macrophages and offers new strategies for future antiviral solutions.
Efficacy and Safety of Keluoxin Capsule in the Treatment of Diabetic Kidney Disease
Authors: Zhou Jingxin , Zhang Wenhua , Yang Jie , Liu Qiaoqiao , Lu Yizhen , Jin Jian , Miao Guizhen , Gong Yanbing 
Published: December 2021

Abstract
Background: Diabetic kidney disease (DKD), which is a serious complication of diabetes and the leading cause of end-stage renal disease, becomes a major health concern worldwide. Keluoxin capsule, a Chinese patent medicine used for DKD, has been widely used in diabetic kidney disease, but its efficacy and safety have not yet been clarified. Therefore, the aim of this systematic review and meta-analysis is to summarize the efficacy and safety of Keluoxin capsule in the treatment of DKD. Methods: A systematic literature search will be conducted in PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure, WANFANG database, VIP, SinoMED, and Chinese Biomedical Literature Database (CBM) to ensure all possible randomized controlled trials (RCT) studies on K eluoxin capsule to November 1, 2021. The primary outcome to be assessed will include the change in albuminuria and estimated glomerular filtration rate (eGFR), while secondary outcomes will be serum creatinine, blood urea nitrogen, glycated hemoglobin, total cholesterol, low-density lipoprotein cholesterol, and triglycerides, etc and adverse events. The quality of the included studies and the risk of bias will be independently assessed by two reviewers using the risk of bias assessment tool from Cochrane Handbook. We will conduct random-effects model meta-analysis using Review Manager software (Revman5.3). Discussion: This systematic review and meta-analysis will objectively evaluate the effect of Keluoxin capsule for DKD, and provide evidence for Keluoxin capsule in the treatment of DKD. Ethics and dissemination : Ethics approval is not required for this study. We aim to publish the results of this systematic review in a peer-reviewed journal. INPLASY registration number: INPLASY 2021110067.
A Protocol for Developing a Clinical Practice Guideline for Prevention and Management of Perineal Tears at Vaginal Delivery
Authors: Shi Lei , Xiao Lin , Ge Long , Liu suting , Luo yuanyuan , Tian Jinhui , Zhang Lili 
Published: December 2021

Abstract
Introduction: Perineal tear is a distressing obstetric complication affecting females globally. More than 85% of women sustain some degree of perineal tears during childbirth, resulting in potential effects on women’s well-being and quality of life. Although different institutions around the world have developed some related clinical practice guidelines (CPGs), a few recommendations are inconsistent, unspecific, and some CPGs are silent on certain matters, which might confuse guideline users. Nowadays, there is still no domestic CPG for prevention and management of perineal tears in China to guide clinical practice.Methods: This CPG will be developed in line with the latest guideline definition from Institute of Medicine (IOM) and comply with the World Health Organization handbook for guideline. We will adhere closely to the six domains of the Appraisal of Guidelines for Research & Evaluation II (AGREE II) and apply the Grade of Recommendations Assessment, Development and Evaluation (GRADE) system to appraise the quality of evidence and develop recommendations. We have established a guideline working group (including a guideline steering group, a guideline development group, a guideline secretary group, and a system evaluation group), formulated 21 questions in the form of Population, Intervention, Comparison, Outcome (PICO) and completed a literature search. The recommendations will be formed via evidence search, syntheses, and 2 to 3 rounds of Delphi process to reach consensus. We will also consider patients’ values or preferences, peer review results in this CPG. Ethics and dissemination: The CPG has been registered on the International Practice Guidelines Registry Platform. The need for ethics approval has been exempted by the Institutional Review Boards of the Southern Medical University. The CPG is to be published in peer-reviewed journals and will form the care standard for perineal care for Chinese women with vaginal delivery.
Hemostatic Efficacy and Safety of the Hemostatic Powder UI-EWD in Patients with Lower Gastrointestinal Bleeding
Authors: Cha Boram , Lee Dong Hyun , Shin Jongbeom , Park Jin-Seok , Kwon Kye Sook , Kim Hyungkil 
Published: December 2021

Abstract
Background and Aims: Acute lower gastrointestinal bleeding (LGIB) is a common cause of emergency hospitalization and may require readmission for re-bleeding. Recently, a novel endoscopic hemostatic powder (UI-EWD/NexpowderTM, Nextbiomedical, Incheon, South Korea) was developed and applied for the control of LGIB. The aim of this study was to evaluate the hemostatic efficacy and long-term safety of UI-EWD in LGIB. Patients and Methods: We conducted a retrospective cohort study of LGIB at a single tertiary center in south korea. One hundred and sixty-seven consecutive patients with LGIB who were initially successful in endoscopic hemostasis were included and divided into the conventional treatment group (n = 112) and the UI-EWD therapy group (n = 55; 38 patients with conventional treatment and 17 patients with UI-EWD alone). The success rate of hemostasis, adverse events related to UI-EWD, and re-bleeding rate were evaluated. Results: The incidence of endoscopic hemostasis applied to the hepatic flexure (7.3% vs. 0%, p = 0.011) and larger than 4 cm (25.5% vs. 8.0%, p = 0.002) were significantly higher in the UI-EWD group than in the conventional therapy group. The cumulative rebleeding rate within 28 days in the UI-EWD group was 5.5% (3/55), which was significantly lower than that in the conventional treatment group (17.0% [19/112]; p = 0.039). No UI-EWD-related adverse events were recorded.Conclusion: Based on our results, application of UI-EWD in LGIB showed promising results for the prevention of re-bleeding, especially in locations where it is difficult to approach or cases with more bleeding. There were no significant complications, such as perforation or embolism. In particular, UI-EWD should be considered first for anatomical or technical impediments to endoscopic access in LGIB.
Bagged Tree And ResNet Based Joint End-to-End Fast CTU Partition Decision Algorithm For Video Intra Coding
Authors: Li Yixiao , Li Lixiang , Fang Yuan , Peng Haipeng , Ling Nam 
Published: December 2021

Abstract

In the development of video coding standards, advanced ones have greatly improved the bit rate compared with those of previous generation, but also brought a huge increase in coding complexity. Coding standards, such as high efficiency video coding (HEVC), versatile video coding (VVC) and AOMedia video 2 (AV2), get the optimal encoding performance by traversing all possible combinations of coding unit (CU) partition and selecting the combination with minimum coding cost. This process of searching for the best makes up a large part of encoding complexity. To reduce the complexity of coding block partition for many video coding standards, this paper proposes an end-to-end fast algorithm for partition structure decision of coding tree unit (CTU) in intra coding. It can be extended to various coding standards with fine tuning, and is applied to the intra coding of HEVC reference software HM16.7 as an example. In the proposed method, the splitting decision of a CTU is made by a well designed bagged tree model firstly. Then, the partition problem of a 32×32 sized CU is modeled as a 17-output classification task and solved by a well trained residual network (ResNet). Jointly using bagged tree and ResNet, the proposed fast CTU partition algorithm is able to generate the partition quad-tree structure of a CTU through an end-to-end prediction process, instead of multiple decision making procedures at depth level. Besides, several effective and representative datasets are also conducted in this paper to lay the foundation of high prediction accuracy. Compared with the original HM16.7 encoder, experimental results show that the proposed algorithm can reduce the encoding time by 59.79% on average, while the BD-rate loss is as less as 2.02%, which outperforms the results of most of state-of-the-art approaches in the fast intra CU partition area.
Real-Time Ultrasound-Guided Stellate Ganglion Block for Migraine: An Observational Study
Authors: Hou Jiawei , Pu Shaofeng , Wu Junzhen , Lu Zhiqiang , Xu Xingguo 
Published: December 2021

Abstract
Objective. To observe whether ultrasound-guided stellate ganglion block (SGB) can effectively relieve migraine pain and improve the quality of migraine patients’ life.Methods. 81 patients with migraines were enrolled in this trial. The patients received SGB with 6 ml of 0.15% ropivacaine once every week for four times. Migraine was assessed with the Migraine Disability Assessment Scale (MIDAS) at baseline and three-months follow-up (Tm). The numerical rating scale (NRS) score at baseline, one day after treatment (Td) and Tm, the frequency of analgesic use in 3 months and the side effects were also recorded at the same time.Results. The NRS score of migraine subjects decreased significantly from 7.0 (2.0) to 3.0 (1.0) at Td and 2.0 (2.0) at Tm (vs baseline, P<0.01). The MIDAS total scores were 14.0 (10.5) at baseline and 7.0 (4.5) at Tm (P<0.001). During the three months, the frequency of analgesic consumption was decreased from 6.2 ± 2.8 to 1.9±1.8. There were no serious side effects. Conclusions. This study confirmed that ultrasound-guided SGB is an effective method to treat migraines. This technique can reduce pain and disability and then improve the quality of life of patients with migraines.
Contraceptive Dynamics Among Women with Disabilities in Low-and Middle-Income Countries: A Scoping Review Protocol
Authors: Beyene Getalem Aychew , Abebe Solomon Mekonnen , Fekadu Gedefaw Abeje , Muche Achenef Asmamaw , Geremew Bisrat Misganaw 
Published: December 2021

Abstract
Introduction
Contraceptive dynamics is the use of contraception, unmet need, discontinuation and/or switching of contraception. Women with disabilities (WWDs) in low- and middle-income countries (LMICs) face a common problem: a low prevalence of contraceptive usage and a high unmet need. Despite the fact that certain studies have been conducted in high-income countries, there is a scarcity of research on the degree of contraceptive method mix, unmet need, contraception discontinuation, and switching among WWDs in LMICs. As a result, the scoping review's goal is to investigate, map available evidence, and identify knowledge gaps on contraceptive dynamics within LMICs WWDs.
Methods
The scoping review is guided by the six-stage Arksey and O'Malley methodology framework. Published articles will be retrieved from databases such as PubMed (Medline), the Cochrane Library, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Global Health. Grey literature databases will be searched using electronic search engines such as Google scholar, Google, OpenGrey, and Worldcat. In addition, a manual search of reference lists from recognized studies will be conducted, as well as a hand search of the literature. There will be no restrictions on study design or publication year. Two independent reviewers will screen relevant publications, and data will be charted accordingly. The Preferred Reporting Items for Systematic Review and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) checklist and reporting guideline will be used to convey the findings of this scoping review.
Discussion
When compared to non-disabled women, WWDs had a lower prevalence of contraceptive usage and a higher unmet need in LMICs. This indicates a pervasive issue that could compromise the United Nations (UN) General Assembly Convention article 25, which guarantees PWDs access to SRH services, and make the situation difficult to address. Despite these facts, they are the most marginalized people. on the planet. It is critical to map available evidence and identify knowledge gaps in order to do this. As a result, the findings of this scoping review will be significant in terms of the contraceptive dynamic among WWDs in LMICs.
Registration:
Open Science Framework (OSF), with registration number; DOI/10.17605/OSF.IO/XCKPT.
Bone Mineral Density Can Be Kept In Spinal Cord Injured Subjects Under Long Term NMES
Authors: Bittar Cintia Kelly , Silva Raissa Cardoso e , Kimoto Emily Ayumi , de Paula Marcelo Chaves , Suguimoto Leonardo , Cliquet Alberto 
Published: December 2021

Abstract
Objective: Analyze the contribution of rehabilitation with neuromuscular electrical stimulation (NMES) assessing bone mineral density (BMD), quality of life aspects and demographic characteristics, after 10 years under treatment.Methods: Retrospective longitudinal study between 2008 and 2020, at Spinal Cord Injury Outpatient Clinic, University Hospital, with 24 individuals with spinal cord injury in rehabilitation with NMES. Identification questionnaire, Functional Independence Measure (FIM) and bone density exam were used for, respectively, demographic analysis, quality of life and BMD. Data from 2008 were catalogued as Pi and current data as Pa. Student’s T-test was used for statistical evaluation, being significantly relevant when p < 0.05.Results: Mean age was 45.3 years old, with 22 male individuals; 14 are paraplegic and 10 are tetraplegic; 13 individuals presented injury by traffic accident, 2 by fall from height, 4 by dive, 4 by firearm injury and 1 by tumor; 11 individuals with cervical-level injury and 13 thoracic-level injury, all with complete disability. FIM average Pi=80.2 and average Pa=84 (p=0.36); BMD of vertebrae L1-L4 average Pi=- 0.02 and average Pa=-0.17 (p=0.50); BMD of femoral neck average Pi=-2.1 and average Pa=-1.9 (p=0.12); outcomes: 2 osteopenia and 1 osteoporosis for L1-L4; 18 osteopenia and 4 osteoporosis for femoral neck.Conclusion: Demographic characteristics were compatible to literature, except for the age. FIM score and BMD remained similar to the beginning of treatment with NMES, concluding that there was stabilization of these parameters during treatment.
Characterization and Critical Appraisal of Physiotherapy Intervention Research in Nigeria: A Systematic Review
Authors: Nweke Martins , Ejiroghene Emeriewen , Fawole Henrietta. O. , Nombeko Mshunqane 
Published: December 2021

Abstract
Objectives
Clinical research is the bedrock of clinical innovation, education and practice. We characterized and critically appraised physiotherapy clinical research to avoid implementing misleading research findings into practice and to task the Nigerian physiotherapy societies on responsible conduct of clinical research.
Methods
This is a systematic review of articles published in English between 2009 and 2021. We searched Pubmed, Medline, Cumulative Index to Nursing and Allied Health Literature, Academic Search Complete, PsycINFO and African Journal Online, and reference lists of relevant articles. Data were selected and extracted according to predesigned eligibility criteria and using a standardized data extraction table. Where appropriate, the Pedro and Cochrane ROBINS1 were used to examine the risk of bias.
Results
Of the clinical experiments, the randomized controlled trial (RCT) was the most common design (87.5%). Musculoskeletal conditions (39.3%) were the most studied disorder. Most of the studies (76.8%) were of suboptimal quality. Interventions constituted exercise therapy (76.3%), manual therapy (8.5%) and electrotherapy (8.5%). More than half (67.8%) of the studies recorded medium to large effect sizes. A fair proportion (48.2%) of the studies had a confounding-by-indication bias. A few studies conducted normality tests (10.9%) and intention-to-treat analysis (37.5%).
Discussion
Of the clinical research, the volume of clinical experiments in the Nigeria Physiotherapy research community is small; notwithstanding, RCT is the most frequent clinical experiment. Physiotherapy interventions especially exercise appears effective, although incongruence between effect size and study quality limits inference. Sources of bias include absent/inadequate covariate analysis, blinding and intention-to-treat analysis approach.
Registration:
We registered the protocol with PROSPERO. The registration number: CRD42021228514.
Numerical Simulation and Experimental Analysis of Volume Alternate Cavitation (VAC) - A new Cavitation Generation Method
Authors: Chen Shangshuang , Wang Yun , Li Fuzhu , Xue Shenwei , Xu Zhenying , Yu Chao , Zhang Kun 
Published: December 2021

Abstract
Cavitation generation methods have been applied in multifarious directions due to their diversity. And scholars have carried out numerous researches and discussions on cavitation generation methods. The purpose of this study is to explore the generating mechanism and evolution law of volumetric alternate cavitation (VAC). In the VAC, the liquid water is placed in an airtight container with variable volume. With the volume alternately changes, the liquid water inside the container continues to cavitate. In this study, the mixture turbulence model and in-cylinder dynamic grid model were used to apply computational fluid dynamics (CFD) simulation of volume alternate cavitation. In the simulation, the cloud images at 7 heights on the central axis are monitored, and the phenomenon and mechanism of height and eccentricity are analyzed detailedly. By using the method of cavitation flow visualization (CFV), the generating mechanism and evolution law of cavitation are clarified. The synergistic effects of experiments and high-speed camera capture confirm the simulation. In the experiment, the volume change stroke of the airtight container is 20 mm, the volume change frequency is 18 Hz, and the shooting frequency of the high-speed camera is set to 10000 fps. The results show that the position of occurring cavitation phenomenon has a reasonable law during the whole evolution cycle of the cavitation cloud. It is evident that a cycle of volume alternation corresponds to the generation, development and collapse stages of cavitation bubbles.