bluuebunny/crossref_metadata_2025_split huggingface dataset:
MiR-539-5p inhibits the inflammatory injury in septic H9c2 cells by regulating IRAK3
Authors: Hu Xiaochen , Miao Hongjun 
Published: November 2021

AbstractBackgroundMicroRNAs (miRNAs) have been confirmed to play a potential role in sepsis, but little is known about their role in sepsis-induced cardiomyopathy (SIC).MethodsThe model of septic cardiomyopathy was constructed with H9c2 cells induced by lipopolysaccharide (LPS), and the expression of miR-539-5p was detected by qRT-PCR assay. ELISA, CCK-8, EdU TUNEL analysis were performed to evaluate the role of miR-539-5p in inflammation response, viability, proliferation and apoptosis of LPS-treated H9c2 cells. Moreover, miRWalk and TargetScan prediction, and dual-luciferase reporter gene assays were carried out to predict and confirm the target of miR-539-5p. Furthermore, the effects of target on inflammation response, proliferation and apoptosis of LPS-induced H9c2 cells mediated by miR-539-5p was further explored.ResultsThe expression of miR-539-5p was obviously down-regulated in LPS-induced H9c2 cells. In addition, over-expression of miR-539-5p significantly inhibited the inflammation response, promoted viability and proliferation, and suppressed apoptosis of LPS-treated H9c2 cells. Moreover, interleukin-1 receptor-associated kinase 3 (IRAK3) was verified as a target of miR-539-5p by dual-luciferase reporter gene assay. Besides, IRAK3 was highly expressed in H9c2 cells transfected with miR-539-5p inhibitor detected with qRT-PCR and western blot assays. Furthermore, over-expression of IRAK3 partially weakened the effects of miR-539-5p mimic on the inflammation response, proliferation and apoptosis of LPS-induced H9c2 cells.ConclusionsMiR-539-5p potentially plays an important role in the pathogenesis of LPS-induced sepsis by targeting IRAK3, suggesting that miR-539-5p may be a potential new target for the treatment of LPS-induced sepsis.
Independently validated sex-specific nomograms for predicting survival in patients with newly diagnosed glioblastoma: NRG Oncology RTOG 0525 and 0825
Authors: Patil Nirav , Somasundaram Eashwar , Waite Kristin A. , Lathia Justin D. , Machtay Mitchell , Gilbert Mark R. , Connor James R. , Rubin Joshua B. , Berens Michael E. , Buerki Robin A. , Choi Serah , Sloan Andrew E. , Penas-Prado Marta , Ashby Lynn S. , Blumenthal Deborah T. , Werner-Wasik Maria , Hunter Grant K. , Flickinger John C. , Wendland Merideth M. , Panet-Raymond Valerie , Robins H. Ian , Pugh Stephanie L. , Mehta Minesh P. , Barnholtz-Sloan Jill S. 
Published: November 2021

Abstract
Background/purpose
Glioblastoma (GBM) is the most common primary malignant brain tumor. Sex has been shown to be an important prognostic factor for GBM. The purpose of this study was to develop and independently validate sex-specific nomograms for estimation of individualized GBM survival probabilities using data from 2 independent NRG Oncology clinical trials.

Methods
This analysis included information on 752 (NRG/RTOG 0525) and 599 (NRG/RTOG 0825) patients with newly diagnosed GBM. The Cox proportional hazard models by sex were developed using NRG/RTOG 0525 and significant variables were identified using a backward selection procedure. The final selected models by sex were then independently validated using NRG/RTOG 0825.

Results
Final nomograms were built by sex. Age at diagnosis, KPS, MGMT promoter methylation and location of tumor were common significant predictors of survival for both sexes. For both sexes, tumors in the frontal lobes had significantly better survival than tumors of multiple sites. Extent of resection, and use of corticosteroids were significant predictors of survival for males.

Conclusions
A sex specific nomogram that assesses individualized survival probabilities (6-, 12- and 24-months) for patients with GBM could be more useful than estimation of overall survival as there are factors that differ between males and females. A user friendly online application can be found here—https://npatilshinyappcalculator.shinyapps.io/SexDifferencesInGBM/.
Variation in floristic and trait composition along environmental gradients in the herb layer of temperate forests in the transition zone between Central and SE Europe
Authors: Kermavnar Janez , Kutnar Lado , Marinšek Aleksander 
Published: November 2021

AbstractSpecies- and trait-environment linkages in forest plant communities continue to be a frequent topic in ecological research. We studied the dependence of floristic and functional trait composition on environmental factors, namely local soil properties, overstory characteristics, climatic parameters and other abiotic and biotic variables. The study area comprised 50 monitoring plots across Slovenia, belonging to the EU ICP Forests monitoring network. Vegetation was surveyed in accordance with harmonized protocols, and environmental variables were either measured or estimated during vegetation sampling. Significant predictors of species composition were identified by canonical correspondence analysis. Correlations between plant traits, i.e. plant growth habit, life form, flowering features and CSR signature, were examined with fourth-corner analysis and linear regressions. Our results show that variation in floristic composition was mainly explained by climatic parameters (mean annual temperature, mean annual precipitation), soil properties (pH) and tree layer-dependent light conditions. Trait composition was most closely related with tree layer characteristics, such as shade-casting ability (SCA, a proxy for light availability in the understory layer), tree species richness and tree species composition. Amongst soil properties, total nitrogen content and soil texture (proportion of clay) were most frequently correlated with different species traits or trait states. The CSR signature of herb communities was associated with tree layer SCA, soil pH and mean annual temperature. The floristic composition of the studied herb-layer vegetation depended on temperature and precipitation, which are likely to be influenced by ongoing climate change (warming and drying). Trait composition exhibited significant links to tree layer characteristics and soil conditions, which are in turn directly modified by forest management interventions.
Measuring Residual Strain and Stress in Thermal Spray Coatings Using Neutron Diffractometers
Authors: Faisal N. H. , Ahmed R. , Prathuru A. K. , Paradowska A. , Lee T. L. 
Published: November 2021

Abstract
Background
During thermal spray coating, residual strain is formed within the coating and substrates due to thermo-mechanical processes and microstructural phase changes.

Objective
This paper provides a comprehensive guide to researchers planning to use neutron diffraction technique for thermal spray coatings, and reviews some of these studies.

Methods
ENGIN-X at the ISIS spallation source is a neutron diffractometer (time-of-flight) dedicated to materials science and engineering with high resolution testing. The focus is on the procedure of using ENGIN-X diffractometer for thermal spray coatings with a view that it can potentially be translated to other diffractometers.

Results
Number of studies involving neutron diffraction analysis in thermal spray coatings remain limited, partly due to limited number of such strain measurement facilities globally, and partly due to difficulty is applying neutron diffraction analysis to measure residual strain in the thermal spray coating microstructure.

Conclusions
This technique can provide a non-destructive through-thickness residual strain analysis in thermally sprayed components with a level of detail not normally achievable by other techniques. Neutron sources have been used to measure strains in thermal spray coatings, and here, we present examples where such coatings have been characterised at various neutron sources worldwide, to study residual strains and microstructures.

Graphic Abstract
Is limited external rotation after reverse shoulder arthroplasty associated with glenoidal notching?
Authors: Grob Alexandra , Bouaicha Samy , Germann Marco , Germann Sabra , Gerber Christian , Wieser Karl 
Published: November 2021

AbstractBackgroundReverse shoulder arthroplasty (RSA) is a valuable solution for patients with shoulder pain or injury primarily due to a rotator cuff tear or secondary to traumatic events. Nevertheless, several complications are known to appear, with the most frequent being scapular notching (SN) on the inferior and posterior scapular neck. Controversial data exist about the clinical relevance of SN. Since further consequences are still not clearly understood, we aimed to provide more clarity on which factors, especially external rotation (ER), contribute to the appearance and progress of notching.MethodsConstant Score (CS), Subjective Shoulder Value (SSV), flexion, abduction, and ER were evaluated retrospectively in 153 shoulders of 147 patients (mean age 79±7.7 years; 62% women) who underwent RSA between 2005 and 2010. Anteroposterior radiographs were evaluated before and 1, 2, 3, and 5 years after RSA for SN according to the Sirveaux classification. The evaluation was performed by two independent surgeons. Spearman’s coefficient andt-test were used.ResultsCS, SSV, flexion, and abduction increased significantly 1 year after RSA compared to before (allp < 0.0001). No improvement was shown for ER between the same timepoints. Between 2 and 5 years of follow-up, only flexion decreased by 5°(p = 0.02) while CS, SSV, abduction, and ER remained constant. After RSA, notching increases over time. There was no association between SN and CS, SSV, flexion, abduction or ER at any of the measured timepoints. Higher flexion correlated with higher abduction after RSA at every follow-up (1 yearr = 0.88, 2 yearsr = 0.89, 3 yearsr = 0.86, 5 yearsr = 0.86). The interrater correlation test showed a strong correlation (r = 0.7).ConclusionWe verified the functional benefits of RSA for patients. Additionally, our findings show that despite radiographic progression of notching and unchanged limited ER, the postoperative improvements in CS, SSV, flexion, and abduction are preserved over 5 years.
Rethinking implementation science for health professions education: A&nbsp;manifesto for change
Authors: Thomas Aliki , Ellaway Rachel H. 
Published: November 2021

Implementation science approaches the challenges of translating evidence into practice as a matter of scientific inquiry. This conceptual paper uses an implementation science lens to examine the ways in which evidence from health professions education research is brought to bear on decision-making. The authors describe different decision-making contexts and the kinds of evidence they consider, and from this, they outline ways in which research findings might be better presented to support their translation into policy and practice. Reflecting on the nature of decision-making in health professions education and how decisions are made and then implemented in different health professions education contexts, the authors argue that researchers should align their work with the decision-making contexts that are most likely to make use of them. These recommendations reflect implementation science principles of packaging and disseminating evidence in ways that are meaningful for key stakeholders, that stem from co-creation of knowledge, that require or result in meaningful partnerships, and that are context specific and relevant.
The concreteness of social knowledge and the quality of democratic choice
Authors: Ou Kai , Tyson Scott A. 
Published: November 2021

AbstractDemocracy relies on citizens who are politically knowledgeable and engaged. However, when a voter gains political knowledge regarding important issues, through television, town halls, or social media, she also learns that there are many other politically knowledgeable voters, highlighting the importance of social knowledge in political participation. Will a voter with concrete—as opposed to hypothetical—knowledge about other voters’ political knowledge have an increased incentive to participate? Or instead, will concrete social knowledge about other voters actually inhibit participation? In this article, we develop a novel experimental design that focuses on whether concrete knowledge about other voters’ political knowledge influences political participation. Our main result shows that concrete social knowledge decreases individual voters’ willingness to vote, and thereby reduces the probability democracy chooses the majority preferred alternative, i.e. the quality of democratic choice.
The Autonomy-Representation Dilemma: Indigenous Groups and Distributive Benefits in the Americas
Authors: Carter Christopher L. 
Published: November 2021

AbstractAutonomy carries the promise of resolving longstanding distributive inequalities between indigenous and non-indigenous groups. Yet, contemporary autonomy arrangements have often been associated instead with a reduction in native communities' access to needed public goods and services. I situate these negative effects within a broader autonomy-representation dilemma: autonomy provides indigenous groups with more responsive coethnic leaders, but these leaders frequently face difficulties in collecting and deploying revenue. These capacity constraints often arise from the way national governments have recognized autonomy. As such, pursuing coethnic representation within the state might—under certain conditions—be more likely to provide indigenous groups with needed goods and services. Drawing on natural experimental evidence and an original survey of indigenous community presidents from Peru, I first demonstrate that achieving coethnic political representation within the state can expand indigenous groups' access to the public good they most need: water. I then illustrate how capacity constraints that arise from autonomy have prevented native groups in Bolivia's autonomous municipalities from achieving similar distributive gains. Ultimately, the findings provide insights for understanding the sources of—and potential institutional remedies for—indigenous groups' unequal access to local public goods in the Americas and beyond.
POLITICS AND PLAY IN THE LAVS PISONIS
Authors: Leventhal Max 
Published: November 2021

AbstractThis article examines the first-century c.e.Laus Pisonis, an anonymous panegyric for a certain Piso that lays particular emphasis on his skill at lyre-playing, ball games and the board game, the ludus latrunculorum (155–210). Whereas this focus has often been a cause of consternation among critics, this article argues that play is a crucial element of the poem's poetic and political operations. The first section shows that the poem employs images of poetic maturity and of temporality in order to justify a light or ludic topic for an allegedly young poet. The second section identifies a hitherto unobserved telestich (M-O-R-A) in the passage describing the ludus latrunculorum and argues that this letter game defines a positive period of play within the poem. The third section further demonstrates that this letter game is aimed specifically at the patron Piso as he is represented within the poem. That is, the poet parallels Piso's potential to uncover the telestich in the text and his ability to uncover the poet's hidden talent. The concluding fourth section explores the wider impact of this reinterpretation of the Laus Pisonis for the literary history of the Early Principate. It proposes that the poem's playfulness should not be seen as reflecting the progressive disempowerment of the political elite. Rather, the poem is an early case of Roman political discourse encroaching on the value of the trivial and the boundaries of otium. The Laus Pisonis makes play political.
Surface culture of Steinernema sp. on two solid media and their pathogenicity against Galleria mellonella
Authors: Cortés-Martínez C.I. , Rodríguez-Hernández A.I. , López-Cuellar M.R. , Chavarría-Hernández N. 
Published: November 2021

Abstract
The use of native entomopathogenic nematodes as biocontrol agents is a strategy to decrease the environmental impact of insecticides and achieve sustainable agriculture crops. In this study, the effect of the surface culture of Steinernema sp. JAP1 over two solid media at 23–27°C on infective juvenile (IJ) production and pathogenicity against Galleria mellonella larvae were investigated. First, the bacterial lawn on the surface of the media with egg yolk (P2) or chicken liver (Cl) were incubated in darkness at 30°C for 48 and 72 h, and 100 surface-sterilized IJs were added. Four harvests were conducted within the next 35 days and the mean accumulated production was superior on Cl (210 × 103 IJs) than on P2 (135 × 103 IJs), but the productivity decreased up to 10% when the incubation time of the bacterial lawn was of 72 h. The mean pathogenicity of in vitro- and in vivo-produced IJs were of 47–64% and 31%, respectively. It is worth noting that none of the two solid media had a statistically significant difference in IJ pathogenicity. Considering that the maximum multiplication factor of IJs on solid media was 2108 and that the pathogenicity against G. mellonella was outstanding, Steinernema sp. has a good potential for in vitro mass production.
The interplay of spatial scale and landscape transformation modulates the abundance and intraspecific variation in the ecomorphological traits of a phyllostomid bat
Authors: Ramírez-Mejía Andrés F. , Urbina-Cardona J. Nicolás , Sánchez Francisco 
Published: November 2021

AbstractLand use intensification imposes selective pressures that systematically change the frequency of wild population phenotypes. Growing evidence is biased towards the comparison of populations from discrete categories of land uses, ignoring the role of landscape emerging properties on the phenotype selection of wild fauna. Across the largest urban–rural gradient of the Colombian Orinoquia, we measured ecomorphological traits of 216 individuals of the flat-faced fruit-eating batArtibeus planirostris.We did this to evaluate the scale of effect at which landscape transformation better predicts changes in phenotype and abundance of an urban-tolerant species. Forest percentage at 1.25 km was the main predictor affecting negatively bat abundance and positively its wing aspect ratio and body mass. Landscape variables affected forearm length at all spatial scales, this effect appeared to be sex-dependent, and the most important predictor, forest percentage at 0.5 km, had a negative effect on this trait. Our results indicate that landscape elements and spatial scale interact to shape ecomorphological traits and the abundance ofA. planirostris. Interestingly, the scale of effect coincided at 1.25 km among all biological responses, suggesting that species’ abundance can be linked to the variation on phenotype under different environmental filters across landscape scenarios.
Constructing Fascist Hagiographies: The Genealogy of the Prison Saints Movement in Contemporary Romania
Authors: Biliuță Ionuț 
Published: November 2021

AbstractThe paper focuses on the ideological roots of the prison saints movement in contemporary Romania. The text uncovers the interwar and communist conceptual premises upon which the biographies of fascist martyrs for canonisation as saints by the Romanian Orthodox Church were shaped. As martyrs for the Christian faith, those deceased were depicted as respectable figures, showcasing their martyrdom on the same moral footing as the dissidents of former democratic parties opposing communism. Furthermore, the narrative strategies in shaping a fascist hagiography from the interwar up to the post-communist years stand as another critical issue for the present article.
Have the Diagnoses of Patients Transported by Ambulances Changed in the Early Stage of the COVID-19 Pandemic?
Authors: Gulen Muge , Satar Salim , Acehan Selen , Bozkurt Mehmet , Aslanturkiyeli Ebru Funda , Sevdimbas Sarper , Esen Cemre Ipek , Balcik Muhammet , Uzucek Mehmet Durdu , Sahin Gonca Koksaldi , Firat Basak Toptas 
Published: November 2021

AbstractIntroduction:Since December 2019, emergency services and Emergency Medical Service (EMS) systems have been at the forefront of the fight against the coronavirus disease 2019 (COVID-19) pandemic world-wide.Objective:The objective of this study was to examine the reasons and the necessity of transportation to the emergency department (ED) by ambulance and the outcomes of these cases with the admissions during the COVID-19 pandemic period and during the same period in 2019.Methods:A retrospective descriptive study was conducted in which patients transported to the ED by ambulance in April 2019 and April 2020 were compared. The primary outcomes were the changes in the number and diagnoses of patients who were transferred to the ED by ambulance during the COVID-19 period. The secondary outcome was the need for patients to be transferred to the hospital by ambulance.Results:A total of 4,466 patients were included in the study. During the COVID-19 period, there was a 41.6% decrease in ED visits and a 31.5% decrease in ambulance calls. The number of critically ill patients transported by ambulance (with diagnoses such as decompensated heart failure [P <.001], chronic obstructive pulmonary disease [COPD] attack (P = .001), renal failure [acute-chronic; P = .008], angina pectoris [P <.001], and syncope [P <.001]) decreased statistically significantly in 2020. Despite this decrease in critical patient calls, non-emergency patient calls continued and 52.2% of the patients transported by ambulance in 2020 were discharged from the ED.Conclusions:Understanding how the COVID-19 pandemic is affecting EMS use is important for evaluating the current state of emergency health care and planning to manage possible future outbreaks.
Analysis of Whistler‐Mode and Z‐Mode Emission in the Juno Primary Mission
Authors: Menietti J. D. , Averkamp T. F. , Kurth W. S. , Imai M. , Faden J. B. , Hospodarsky G. B. , Santolik O. , Clark G. , Allegrini F. , Elliott S. S. , Sulaiman A. H. , Bolton S. J. 
Published: November 2021

AbstractAt the end of the Juno primary mission, we report observations of whistler mode chorus and Z‐mode emission. The Juno orbits are evolving and much better coverage of the whistler mode chorus source region has resulted since the earlier surveys. Bursty chorus emission extending to ∼30° latitude and to frequencies less than the lower hybrid frequency near the source region imply high electron energies (>100 keV). Average chorus intensity levels peak at ∼10−3 nT2 near M‐shell of 8–9 and magnetic latitude of ∼5°. Z‐mode emission is identified at higher latitudes generally near and inward of the Io torus with intensity levels as much as two orders of magnitude higher than Z‐mode emissions observed at Saturn. Inferred source regions for the Z‐mode are consistent with the inner edge of the Io torus and with auroral field lines that may also support Jovian kilometric and decametric emission. Parametric fitting functions are evaluated for both whistler mode chorus and Z‐mode, describing wave intensity as a function of frequency, magnetic latitude, and M‐shell. Both whistler mode and Z‐mode waves may have significant impact on electron scattering and acceleration at Jupiter as recent models indicate.