bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review of: «The Woman clothed in the Sun»: an origin of the image. Moscow: Russian State University for the Humanities, 2015. 334 p. ISBN 978-5-7281-1765-0
Authors: Вевюрко Илья Сергеевич 
Published: February 2021

В работе Катерины Кудрявцевой перспектива рассмотрения загадочного образа из Апокалипсиса иная — не богословская, а, скорее, религиоведческая. Но религиоведческая точка зрения не может не включать в себя богословскую, иначе она рискует исказить свой предмет — религию, обойдя вниманием её вероучительную сторону. К. Г. Кудрявцевой удалось прийти к богословскому рассмотрению образа религиоведческим путём, а именно путём расшифровки его семантики. В этом смысле её исследование подобно работе с красками, восстанавливающими цвета фрески до первоначальной яркости (пусть виртуально, чтобы не вмешаться с новой кистью в исторически сохранившиеся слои), в то время как схема рисунка и его сюжет остаются теми же самыми. К. Г. Кудрявцева берёт за основу нарратив видения св. апостола Иоанна, который она разделяет на четыре аспекта и даёт им довольно поэтические названия: «Застигнутая жизнью и смертью»; «Свечение»; «Противостояние как погоня»; «Город». По этим четырём ключевым темам распределена на параграфы каждая из пяти глав работы, которые охватывают мировой фольклор, корпус канонических книг Ветхого Завета, письменность эпохи Второго Храма, литературный контекст Откровения св. Иоанна Богослова (то есть тоже произведения периода Второго Храма, но наиболее близкие по развитию своей образности к Апокалипсису) и, наконец, сам текст Откровения.
In Katerina Kudryavtseva's work, the perspective of the enigmatic image from the Apocalypse is different - not theological but, rather, religious studies. But a theological perspective could not avoid incorporating a theological perspective, otherwise it would risk distorting its subject, religion, by neglecting its doctrinal side. K.G. Kudryavtseva was able to reach a theological consideration of the image in a theological way, namely by deciphering its semantics. In this sense, her research is like working with paints, restoring the colours of a fresco to their original brightness (albeit virtually, so as not to intervene with a new brush in the historically preserved layers), while the scheme of the drawing and its subject remain the same. K.G. Kudryavtseva takes as a basis the narrative of St. John's vision, which she divides into four aspects and gives them rather poetic titles: "Caught in Life and Death"; "Illumination"; "Confrontation as Chase"; "City". Each of the five chapters is divided into paragraphs according to these four key themes, covering world folklore, the corpus of canonical books of the Old Testament, the writing of the Second Temple period, the literary context of the Revelation of Saint John the Evangelist (that is, also works from the Second Temple period, but closest in their development of imagery to the Apocalypse) and, finally, the text of Revelation itself.
Review of the Scientific and Practical Conference «Semantics of Grammatical Markers in Semitic Languages and Approaches to Its Description» (February 13-14, 2020)
Authors: Калинин Максим Глебович 
Published: February 2021

В 2020 г. (13–14 февраля) в Свободном университете Берлина (Freie Universität Berlin, далее — FUB) состоялась международная научно-практическая конференция «Семантика грамматических маркеров в семитских языках и подходы к их описанию» (Semantics of Grammatical Markers in Semitic Languages and Approaches to Its Description). Конференция прошла на базе кафедры семитистики и арабистики Свободного университета Берлина и собрала учёных из Германии, Великобритании, Франции, России, Израиля и Нидерландов.
In the year 2020 (13-14 February) the Freie Universität Berlin (FUB) held an international conference on "Semantics of Grammatical Markers in Semitic Languages. On February 13-14 the Freie Universität Berlin (FUB) hosted an international conference on Semantics of Grammatical Markers in Semitic Languages and Approaches to Its Description (Semantics of Grammatical Markers in Semitic Languages and Approaches to Its Description). The conference was hosted by the Department of Semitics and Arabic Studies of the Free University of Berlin and brought together scholars from Germany, the UK, France, Russia, Israel and the Netherlands.
Ryanodine Receptor 1-Related Myopathies: Quantification of Intramuscular Fatty Infiltration from T1-Weighted MRI
Authors: Lawal Tokunbor A. , Patankar Aneesh , Todd Joshua J. , Razaqyar Muslima S. , Chrismer Irene C. , Zhang Xuemin , Waite Melissa R. , Jain Minal S. , Emile-Backer Magalie , Witherspoon Jessica W. , Liu Chia-Ying , Grunseich Christopher , Meilleur Katherine G. 
Published: February 2021

Background: Ryanodine receptor 1-related myopathy (RYR1-RM) can present with a selective pattern and gradient of intramuscular fatty infiltration (IMFI) on magnetic resonance imaging (MRI). Objective: To demonstrate an automated protocol for quantification of IMFI in the lower extremity muscles of individuals with RYR1-RM using T1-weighted MRI and to examine the relationships of IMFI with motor function and clinical severity. Methods: Axial images of the lower extremity muscles were acquired by T1-weighted fast spin-echo and short tau inversion recovery (STIR) sequences. A modified ImageJ-based program was used for quantification. IMFI data was analyzed by mode of inheritance, motor function, and clinical severity. Results: Upper and lower leg IMFI from 36 genetically confirmed and ambulatory RYR1-RM affected individuals (26 dominant and 10 recessive) were analyzed using Grey-scale quantification. There was no statistically significant difference in IMFI between dominant and recessive cases in upper or lower legs. IMFI in both upper and lower legs was inversely correlated with participant performance on the motor function measure (MFM-32) total score (upper leg: p < 0.001; lower leg: p = 0.003) and the six-minute walk test (6MWT) distance (upper leg: p < 0.001; lower leg: p = 0.010). There was no significant difference in mean IMFI between participants with mild versus severe clinical phenotypes ( p = 0.257). Conclusion: A modified ImageJ-based algorithm was able to select and quantify fatty infiltration in a cohort of heterogeneously affected individuals with RYR1-RM. IMFI was not predictive of mode of inheritance but showed strong correlation with motor function and capacity tests including MFM-32 and 6MWT, respectively.
The Role of Nutrition and Physical Activity as Trigger Factors of Paralytic Attacks in Primary Periodic Paralysis
Authors: Welland Natasha Lervaag , Hæstad Helge , Fossmo Hanne Ludt , Giltvedt Kaja , Ørstavik Kristin , Nordstrøm Marianne 
Published: February 2021

Background: Primary periodic paralysis (PPP) are rare inherited neuromuscular disorders including Hypokalemic periodic paralysis (HypoPP), Hyperkalemic periodic paralysis (HyperPP) and Andersen-Tawil syndrome (ATS) characterised by attacks of weakness or paralysis of skeletal muscles. Limited effective pharmacological treatments are available, and avoidance of lifestyle related triggers seems important. Objective: Our aim was to search and assess the scientific literature for information on trigger factors related to nutrition and physical activity in PPP. Methods: We searched Ovid Medline and Embase database for scientific papers published between January 1, 1990, to January 31, 2020. Results: We did not identify published observation or intervention studies evaluating effect of lifestyle changes on attacks. Current knowledge is based on case-reports, expert opinions, and retrospective case studies with inadequate methods for description of nutrition and physical activity. In HypoPP, high carbohydrate and salt intake, over-eating, alcohol, dehydration, hard physical activity, and rest after exercise are frequently reported triggers. Regarding HyperPP, fasting, intake of potassium, alcohol, cold foods or beverages, physical activity, and rest after exercise are frequently reported triggers. No nutrition related triggers are reported regarding ATS, exercise can however induce ventricular arrhythmias. Conclusions: Our results support that dietary intake and physical activity may play a role in causing paralytic attacks in PPP, although the current scientific evidence is weak. To provide good evidence-based patient care, several lifestyle aspects need to be further assessed and described.
A SURVEY ON ONCOPLASTIC BREAST SURGERY AWARENESS AND PRACTICE PATTERNS AMONG INDIAN SURGEONS: A CROSS-SECTIONAL STUDY
Authors: Mishra Vinayak , Kelkar Rajashri , Agrawal Aditi , Matcheswalla Sakina 
Published: February 2021

Purpose: To assess the perspective and practice patterns of Indian surgeons concerning OBS and compare urban and rural areas.
Patients and methods: A thirteen-question survey was distributed through the social media platform WhatsApp (WhatsApp Inc, California, US) to various Indian surgical society groups across India from 5th May 2020 to 19th May 2020. The questions focused on the surgeons' experience, surgical management technique of choice in breast cancer patients, acceptance and practice of OBS, knowledge of type 1 and type 2 OBS, and axilla management.
Results: Two hundred ninety surgeons responded to the survey out of about 1000, with a response rate of 29%. 17.99% of the surgeons (n=52) practiced in a rural region, while 82.01% (n=237) practiced in an urban region. 94.12% (n=272) of the surgeons reported awareness about oncoplastic breast surgery (OBS), whereas only 5.88% (n= 17) were unaware of the existence of this procedure. 62.97% (n=182) surgeons offered OBS to their breast cancer patients, while 37.02% (n=107) did not offer OBS. 49.37% of surgeons in the urban areas do not perform OBS, whereas 78.85% do not perform it in the rural regions. It also highlights that the percentage of surgeons performing OBS with a plastic surgeon (29.41%) is higher than those who carry out the procedure by themselves (15.92%).
Conclusion: Most of the Indian surgeons are aware of OBS. In the rural areas, OBS's rate is minimal due to various reasons such as poverty, illiteracy, inaccessible radiotherapy centers, and the absence of training of surgeons in OBS. Few urban surgeons perform OBS themselves while most of them do it with the help of plastic surgeons. Mastectomy is the most commonly performed surgical intervention for breast cancer in rural regions. The practice of OBS should increase in India to improve the postoperative quality of life of breast cancer patients.
Keywords: Oncoplastic Breast Surgery, Mastectomy, Breast-conserving surgery, Indian surgeons, Oncoplasty
Modelado mediante redes de colas abiertas con realimentación de la sala de urgencias de un hospital público
Authors: Aceves-Gómez Gonzalo Everardo , González-Silva Ricardo Armando , Juárez-López Héctor Alfonso , Medina Ramírez Rodolfo Rafael , Vázquez-Ibarra José Antonio 
Published: February 2021

Este trabajo propone un modelo de red de colas abiertas con realimentación, de la sala de urgencias, para entender su comportamiento y tomar decisiones estratégicas. Se establece una matriz de ruta deprobabilidades en la red de colas para determinar de manera general las variantes de comportamiento de este modelo, generando así un rango de escenarios con diferentes patrones de comportamiento; con los resultados numéricos, se analizan los indicadores de eficiencia de la Teoría de Colas de las tres locaciones: consultorios, laboratorios y observación-yesos-suturas, las cuales se modelan con M/M/s, M/G/1 y M/M/1, respectivamente. Los resultados del análisis numérico muestran la sensibilidad del comportamiento de la sala de urgencias con base en los valores de la matriz de ruta de probabilidades y en cuáles valores funciona óptimamente.
Síndrome de gorlin-goltz – relato de caso
Authors: Jardim Virgílio Bernardino Ferraz , Barros Allan Vinícius Martins de , Araújo Rafaella Amorim Bittencourt Maranhão de , Ramos Lucas Viana Silva , Lima Luiz Fernando Alves de , Silva Emanuel Dias de Oliveira e 
Published: February 2021

Introdução: A síndrome de Gorlin-Goltz é também denominada de síndrome do nevo basocelular ou síndrome do carcinoma nevóide de células basais. Esta é uma rara desordem hereditária autossômica dominante, causada pela mutação no gene supressor de tumor PTCH1. Relato de caso: Paciente do gênero masculino, 15 anos de idade, procurou o serviço de Cirurgia e Traumatologia Buco-Maxilo-Facial, relatando dores discretas na região retromolar direita, sendo solicitada uma ortopantomografia, notando-se a presença de 1 lesão na maxila e 2 lesões na mandíbula (esquerda e direita), todas associadas a dentes impactados. Na investigação, encontrou-se calcificação da foice cerebral, pontificação da sela túrcica, e depressões na região plantar dos pés. Foi realizada a enucleação e curetagem das lesões maxilares e remoção dos dentes impactados. Ao exame histopatológico, foi diagnosticado Ceratocisto Odontogênico. Discussão: A SGG consiste em um transtorno neurocutâneo, que se manifesta principalmente em pacientes jovens, sem predileção por gênero. Kimonis et Al (1997) determinam uma forma de diagnóstico através da presença de critérios maiores e critérios menores. No caso relatado foi encontrado três critérios maiores e um critério menor. Conclui-se, portanto, que apesar dos diversos achados para diagnóstico, o de maior relevância para o cirurgião Buco-Maxilo-Facial são os ceratocistos, tendo um alto poder de recidiva e destruição, estando presente em 70% dos casos de SGG, sendo mais frequente na mandíbula e associado a dentes inclusos. Até o momento, o diagnóstico e tratamento do caso mencionado foi satisfatório, fazendo-se necessário também um acompanhamento multiprofissional.
Conformational Changes of Glutamine 5′-Phosphoribosylpyrophosphate Amidotransferase for Two Substrates Analogue Binding: Insight from Conventional Molecular Dynamics and Accelerated Molecular Dynamics Simulations
Authors: Li Congcong , Chen Siao , Huang Tianci , Zhang Fangning , Yuan Jiawei , Chang Hao , Li Wannan , Han Weiwei 
Published: February 2021

Glutamine 5′-phosphoribosylpyrophosphate amidotransferase (GPATase) catalyzes the synthesis of phosphoribosylamine, pyrophosphate, and glutamate from phosphoribosylpyrophosphate, as well as glutamine at two sites (i.e., glutaminase and phosphoribosylpyrophosphate sites), through a 20 Å NH3 channel. In this study, conventional molecular dynamics (cMD) simulations and enhanced sampling accelerated molecular dynamics (aMD) simulations were integrated to characterize the mechanism for coordination catalysis at two separate active sites in the enzyme. Results of cMD simulations illustrated the mechanism by which two substrate analogues, namely, DON and cPRPP, affect the structural stability of GPATase from the perspective of dynamic behavior. aMD simulations obtained several key findings. First, a comparison of protein conformational changes in the complexes of GPATase–DON and GPATase–DON–cPRPP showed that binding cPRPP to the PRTase flexible loop (K326 to L350) substantially effected the formation of the R73-DON salt bridge. Moreover, only the PRTase flexible loop in the GPATase–DON–cPRPP complex could remain closed and had sufficient space for cPRPP binding, indicating that binding of DON to the glutamine loop had an impact on the PRTase flexible loop. Finally, both DON and cPRPP tightly bonded to the two domains, thereby inducing the glutamine loop and the PRTase flexible loop to move close to each other. This movement facilitated the transfer of NH3 via the NH3 channel. These theoretical results are useful to the ongoing research on efficient inhibitors related to GPATase.
The U-Shape Relationship Between Glycated Hemoglobin Level and Long-Term All-Cause Mortality Among Patients With Coronary Artery Disease
Authors: Liu Liwei , Ye Jianfeng , Ying Ming , Li Qiang , Chen Shiqun , Wang Bo , Lin Yihang , Chen Guanzhong , Lun Zhubin , Huang Haozhang , Li Huangqiang , Xu Danyuan , Tan Ning , Chen Jiyan , Liu Jin , Liu Yong 
Published: February 2021

Background: Although glycated hemoglobin (HbA1c) was considered as a prognostic factor in some subgroup of coronary artery disease (CAD), the specific relationship between HbA1c and the long-term all-cause death remains controversial in patients with CAD.Methods: The study enrolled 37,596 CAD patients and measured HbAlc at admission in Guangdong Provincial People's Hospital. The patients were divided into 4 groups according to HbAlc level (Quartile 1: HbA1c ≤ 5.7%; Quartile 2: 5.7% &lt; HbA1c ≤ 6.1%; Quartile 3: 6.1% &lt; HbA1c ≤ 6.7%; Quartile 4: HbA1c &gt; 6.7%). The study endpoint was all-cause death. The restricted cubic splines and cox proportional hazards models were used to investigate the association between baseline HbAlc levels and long-term all-cause mortality.Results: The median follow-up was 4 years. The cox proportional hazards models revealed that HbAlc is an independent risk factor in the long-term all-cause mortality. We also found an approximate U-shape association between HbA1c and the risk of mortality, including increased risk of mortality when HbA1c ≤ 5.7% and HbA1c &gt; 6.7% [Compared with Quartile 2, Quartile 1 (HbA1c ≤ 5.7), aHR = 1.13, 95% CI:1.01–1.26, P &lt; 0.05; Quartile 3 (6.1% &lt; HbA1c ≤ 6.7%), aHR = 1.04, 95% CI:0.93–1.17, P =0.49; Quartile 4 (HbA1c &gt; 6.7%), aHR = 1.32, 95% CI:1.19–1.47, P &lt; 0.05].Conclusions: Our study indicated a U-shape relationship between HbA1c and long-term all-cause mortality in CAD patients.
Source Mechanism of Seismic Explosion Signals at Santiaguito Volcano, Guatemala: New Insights From Seismic Analysis and Numerical Modeling
Authors: Rohnacher Alicia , Rietbrock Andreas , Gottschämmer Ellen , Carter William , Lavallée Yan , De Angelis Silvio , Kendrick Jackie E. , Chigna Gustavo 
Published: February 2021

Volcanic activity at the Santiaguito dome complex (Guatemala) is characterized by lava extrusion interspersed with small, regular, gas-and-ash explosions that are believed to result from shallow magma fragmentation; yet, their triggering mechanisms remain debated. Given that the understanding of source processes at volcanoes is essential to risk assessments of future eruptions, this study seeks to shed light on those processes. We use data from a permanent seismic and infrasound network at Santiaguito volcano, Guatemala, established in 2018 and additional temporary stations, including a seismic array deployed during a 13-day field investigation in January 2019 to analyze and resolve the source characteristics of fragmentation leading to gas-and-ash explosions. Seismic data gathered within a distance of 4.5 km from the vent show a weak seismic signal 2–6 s prior to the explosions and associated main seismic signal. To resolve the source location and origin of the seismic signals, we first used ambient noise analysis to assess seismic velocities in the subsurface and then used two-dimensional spectral element modeling (SPECFEM2D) to simulate seismic waveforms. The analyzed data revealed a two-layer structure beneath the array, with a shallow, low-velocity layer (vs= 650 m/s) above deeper, high-velocity rocks (vs= 2,650 m/s). Using this velocity structure, possible source mechanisms and depths were constrained using array and particle motion analyses. The comparison of simulated and observed seismic data indicated that the precursory signal is associated with particle motion in the RZ-plane, pointing toward the opening of tensile cracks at a depth of ∼600 m below the summit; in contrast, the main signal is accompanied by a vertical single force, originating at a shallow depth of about ∼200 m. This suggests that the volcanic explosions at Santiaguito are following a bottom-up process in which tensile fractures develop at depth and enable rapid gas rise which leads to the subsequent explosion. The result indicates that explosions at Santiaguito do not occur from a single source location, but from a series of processes possibly associated with magma rupture, gas channeling and accumulation, and fragmentation. Our study provides a good foundation for further investigations at Santiaguito and shows the value of comparing seismic observations with synthetic data calculated for complex media to investigate in detail the processes leading up to gas-ash-rich explosions found at various other volcanoes worldwide.
Selecting Mathematical Tasks for Assessing Student’s Understanding: Pre-Service Teachers’ Sensitivity to and Adaptive Use of Diagnostic Task Potential in Simulated Diagnostic One-To-One Interviews
Authors: Kron Stephanie , Sommerhoff Daniel , Achtner Maike , Ufer Stefan 
Published: February 2021

Teachers’ diagnostic competences are regarded as highly important for classroom assessment and teacher decision making. Prior conceptualizations of diagnostic competences as judgement accuracy have been extended to include a wider understanding of what constitutes a diagnosis; novel models of teachers’ diagnostic competences explicitly include the diagnostic process as the core of diagnosing. In this context, domain-general and mathematics-specific research emphasizes the importance of tasks used to elicit student cognition. However, the role of (mathematical) tasks in diagnostic processes has not yet attracted much systematic empirical research interest. In particular, it is currently unclear whether teachers consider diagnostic task potential when selecting tasks for diagnostic interviews and how this relationship is shaped by their professional knowledge. This study focuses on pre-service mathematics teachers’ selection of tasks during one-to-one diagnostic interviews in live simulations. Each participant worked on two 30 mins interviews in the role of a teacher, diagnosing a student’s mathematical understanding of decimal fractions. The participants’ professional knowledge was measured afterward. Trained assistants played simulated students, who portrayed one of four student case profiles, each having different mathematical (mis-)conceptions of decimal fractions. For the interview, participants could select tasks from a set of 45 tasks with different diagnostic task potentials. Two aspects of task selection during the diagnostic processes were analyzed: participants’ sensitivity to the diagnostic potential, which was reflected in higher odds for selecting tasks with high potential than tasks with low potential, and the adaptive use of diagnostic task potential, which was reflected in task selection influenced by a task’s diagnostic potential in combination with previously collected information about the student’s understanding. The results show that participants vary in their sensitivity to diagnostic task potential, but not in their adaptive use. Moreover, participants’ content knowledge had a significant effect on their sensitivity. However, the effects of pedagogical content and pedagogical knowledge did not reach significance. The results highlight that pre-service teachers require further support to effectively attend to diagnostic task potential. Simulations were used for assessment purposes in this study, and they appear promising for this purpose because they allow for the creation of authentic yet controlled situations.