bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Review: Diabetes Family Conflict in Young People With Type 1 Diabetes
Authors: Hickling Anna , Dingle Genevieve A , Barrett Helen L , Cobham Vanessa E 
Published: May 2021

Abstract

Objective
To investigate the relationships between diabetes-specific family conflict and health outcomes of young people with type 1 diabetes (T1D).

Methods
A systematic review was performed according to the PRISMA statement (registration number: CRD42020164988). PubMed, Embase, PsycNET, reference lists of included studies, and other relevant reviews were searched (1990–2020). Two independent reviewers screened titles, abstracts, and full-texts. Studies were included if they sampled young people with T1D (mean age between 14 and 25 years) and examined the relationship between diabetes-specific family conflict and the following outcomes: glycated hemoglobin (HbA1c), treatment adherence, blood glucose monitoring, depression, anxiety, quality of life, and/or well-being.

Results
A total of 20 studies met the predetermined inclusion criteria. Greater diabetes-specific family conflict was significantly related to higher HbA1c values in 17 studies. Seven studies reported a significant association between greater diabetes family conflict and suboptimal treatment adherence and/or less frequent blood glucose monitoring. However, significant relationships between conflict and HbA1c and/or treatment adherence were not found in four studies. Seven studies in total reported that greater diabetes family conflict was significantly related to poorer quality of life or well-being and greater depressive and/or anxiety symptoms in young people.

Conclusions
Diabetes-specific family conflict is associated with some adverse health outcomes for young people with T1D. However, more longitudinal studies of young people aged older than 16 years are needed. Screening for and addressing diabetes-specific family conflict is recommended, given the growing number of studies linking family conflict to various adverse health outcomes in young people with T1D.
Do Inattention/Hyperactivity and Motor Timing Predict Children’s Virtual Road-Crossing Performance?
Authors: Parr Morgan N D , Tang Hanxi , Mallaro Sophia R , Kearney Joseph K , Plumert Jodie M 
Published: May 2021

Abstract

Objective
The goal of this investigation was to examine how individual variation in inattention and hyperactivity is related to motor timing difficulties and whether children’s performance on simple laboratory timing tasks is related to their performance on a virtual road-crossing task using a head-mounted virtual reality display system.

Methods
Participants were a community sample of 92 9- to 11-year-old children. Parents completed questionnaires assessing their child’s inattention and hyperactivity. Children completed two simple motor timing tasks (duration discrimination and synchronization-continuation) and crossed roads with continuous traffic in a head-mounted VR system.

Results
Higher parent-reported inattention and hyperactivity predicted poorer performance in the duration discrimination and synchronization-continuation tasks, but not the virtual pedestrian road-crossing task. Children with higher tap onset asynchrony in the synchronization-continuation task had poorer timing of entry into the gap in the virtual pedestrian road-crossing task.

Conclusions
The findings provide further evidence that timing deficits are associated with individual differences in inattention and hyperactivity and that timing difficulties may be a risk factor for functional difficulties in everyday life.
Magnetic chemically peculiar stars investigated by the Solar Mass Ejection Imager
Authors: Paunzen E , Supíková J , Bernhard K , Hümmerich S , Prišegen M 
Published: May 2021

ABSTRACT
Since the discovery of the spectral peculiarities of their prototype α2 Canum Venaticorum in 1897, the so-called ACV variables, which are comprised of several groups of chemically peculiar stars of the upper main sequence, have been the target of numerous photometric and spectroscopic studies. Especially for the brighter ACV variables, continuous observations over about a century are available, which are important to study long-term effects such as period changes or magnetic cycles in these objects. This work presents an analysis of 165 Ap/CP2 and He-weak/CP4 stars using light curves obtained by the Solar Mass Ejection Imager (SMEI) between the years 2003 and 2011. These data fill an important gap in observations for bright ACV variables between the Hipparcos and TESS satellite missions. Using specifically tailored data treatment and period search approaches, we find variability in the accuracy limit of the employed data in 84 objects. The derived periods are in excellent agreement with the literature; for one star, the here presented solution represents the first published period. We discuss the apparently constant stars and the corresponding level of non-variability. From an investigation of our target star sample in the Hertzsprung–Russell diagram, we deduce ages between 100 Myr and 1 Gyr for the majority of our sample stars. Our results support that the variable CP2/4 stars are in a more advanced evolutionary state and that He and Si peculiarities, preferentially found in the hotter, and thus more massive, CP stars, produce larger spots or spots of higher contrast.
Molecular line ratio diagnostics and gas kinematics in the AGN host Seyfert galaxy NGC 5033
Authors: Topal Selçuk 
Published: May 2021

ABSTRACT
Multiple molecular lines are useful for studying the physical properties of multiphase star-forming gas in different types of galaxies. We probe the molecular gas throughout the disc of the spiral galaxy NGC 5033, hosting an active galactic nucleus (AGN), using multiple low-J CO lines [12CO(1–0, 2–1, 3–2 and 13CO(1–0, 2–1)] and dense gas tracers [HCN(1–0) and HCO+(1–0)]. First, we determine the ratios of the integrated intensity maps and the ratio of intensities in position velocity diagrams. Secondly, we obtain the ratios of CO lines and high-density tracers at the centre; and thirdly, we model these line ratios using a radiative transfer code. Line ratio diagnostics reveal that the south of the gaseous disc contains cooler gas than the northern part, and the centre hosts warmer and less tenuous gas with a similar dense gas fraction compared to most galaxies of similar type. Our model results mostly agree with the empirical ones in the sense that the central region of NGC 5033 harbours warmer gas than that in the centres of normal spirals and lenticulars without showing AGN activity. Finally, the beam-averaged total molecular gas mass and gas surface density along the galaxy’s major axis show a radial gradient, i.e. increasing from the outskirts up to the central region of size 1 kpc where there is a depression in both gas mass and surface density.
Optical spectral characterization of the gamma-ray blazars S4 0954+65, TXS 1515−273, and RX J0812.0+0237
Authors: González J Becerra , Acosta-Pulido J A , Boschin W , Clavero R , Otero-Santos J , Carballo-Bello J A , Domínguez-Palmero L 
Published: May 2021

ABSTRACT
The study of gamma-ray blazars is usually hindered due to the lack of information on their redshifts and on their low-energy photon fields. This information is key to understand the effect on the gamma-ray absorption due to either extragalactic background light and/or intrinsic absorption and emission processes. All this information has also an impact on the determination of the location of the emitting region within the relativistic jets. In this work, a new optical spectroscopic characterization is presented for three gamma-ray blazars: S4 0954+65, TXS 1515−273, and RX J0812.0+0237. For all the three targets, the redshift determination is successful, and for the first time in the case of TXS 1515−273 and RX J0812.0+0237. Their classification as BL Lac type is confirmed based on these new optical spectra. For S4 0954+65 (z = 0.3694 ± 0.0011), an estimation on the disc, broad-line region, and torus luminosities is performed based on the observed optical emission lines. The results from this study are compatible with the nature of S4 0954+65 as a transitional blazar. In the case of TXS 1515−273 (z = 0.1281 ± 0.0004), although its optical spectrum is dominated by the continuum emission from the jet, applying the pPXF technique, the stellar population can be unveiled and is compatible with an old and metallic population. It is also the case of RX J0812.0+0237 (z = 0.1721 ± 0.0002). Moreover, this work confirms that the optical spectrum from RX J0812.0+0237 is compatible with an extreme blazar classification.
Secular dynamics of binaries in stellar clusters – III. Doubly averaged dynamics in the presence of general-relativistic precession
Authors: Hamilton Chris , Rafikov Roman R 
Published: May 2021

ABSTRACT
Secular evolution of binaries driven by an external (tidal) potential is a classic astrophysical problem. Tidal perturbations can arise due to an external point mass, as in the Lidov–Kozai (LK) theory of hierarchical triples, or due to an extended stellar system (e.g. galaxy or globular cluster) in which the binary resides. For many applications, general-relativistic (GR) apsidal precession is important, and has been accounted for in some LK calculations. Here, we generalize and extend these studies by exploring in detail the effect of GR precession on (quadrupole-level) tidal evolution of binaries orbiting in arbitrary axisymmetric potentials (which includes LK theory as a special case). We study the (doubly averaged) orbital dynamics for arbitrary strengths of GR and binary initial conditions and uncover entirely new phase space morphologies with important implications for the binary orbital evolution. We also explore how GR precession affects secular evolution of binary orbital elements when the binary reaches high eccentricity (e → 1) and delineate several different dynamical regimes. Our results are applicable to a variety of astrophysical systems. In particular, they can be used to understand the high eccentricity behaviour of (cluster) tide-driven compact object mergers – i.e. LIGO/Virgo gravitational wave sources – for which GR effects are crucial.
Rosella: a mock catalogue from the P-Millennium simulation
Authors: Gaines Sasha , Norberg Peder , Cole Shaun 
Published: May 2021

ABSTRACT
The scientific exploitation of the Dark Energy Spectroscopic Instrument Bright Galaxy Survey (DESI BGS) data requires the construction of mocks with galaxy population properties closely mimicking those of the actual DESI BGS targets. We create a high-fidelity mock galaxy catalogue, including information about galaxies and their host dark matter subhaloes. The mock catalogue uses subhalo abundance matching with scatter to populate the P-Millennium N-body simulation with galaxies at the median BGS redshift of ∼0.2, using formation redshift information to assign 0.1(g − r) rest-frame colours. The mock provides information about r-band absolute magnitudes, 0.1(g − r) rest-frame colours, and 3D positions and velocities of a complete sample of DESI BGS galaxies in a volume of (542 Mpc h−1)3, as well as the masses of host dark matter haloes. This P-Millennium DESI BGS mock catalogue is ideally suited for the tuning of approximate mocks unable to resolve subhaloes that DESI BGS galaxies reside in, to test for systematics in analysis pipelines and to interpret (non-cosmological focused) DESI BGS analysis.
The first measurement of the quasar lifetime distribution
Authors: Khrykin Ilya S , Hennawi Joseph F , Worseck Gábor , Davies Frederick B 
Published: May 2021

ABSTRACT
Understanding the growth of the supermassive black holes (SMBH) powering luminous quasars, their co-evolution with host galaxies, and impact on the surrounding intergalactic medium (IGM) depends sensitively on the duration of quasar accretion episodes. Unfortunately, this time-scale, known as the quasar lifetime, tQ, is still uncertain by orders of magnitude ($t_{\rm Q} \simeq 0.01\, {\rm Myr} - 1\, {\rm Gyr}$). However, the extent of the He ii Ly α proximity zones in the absorption spectra of zqso ∼ 3–4 quasars constitutes a unique probe, providing sensitivity to lifetimes up to ∼30 Myr. Our recent analysis of 22 archival Hubble Space Telescope He ii proximity zone spectra reveals a surprisingly broad range of emission time-scales, indicating that some quasars turned on ≲1 Myr ago, whereas others have been shining for ≳30 Myr. Determining the underlying quasar lifetime distribution (QLD) from proximity zone measurements is a challenging task owing to: (1) the limited sensitivity of individual measurements; (2) random sampling of the quasar light curves; (3) density fluctuations in the quasar environment; and (4) the inhomogeneous ionization state of He ii in a reionizing IGM. We combine a seminumerical He ii reionization model, hydrodynamical simulations post-processed with ionizing radiative transfer, and a novel statistical framework to infer the QLD from an ensemble of proximity zone measurements. Assuming a lognormal QLD, we infer a mean $\langle {\rm log}_{10}(t_{\rm Q} / {\rm Myr})\rangle = 0.22^{+0.22}_{-0.25}$ and standard deviation $\sigma _{{\rm log}_{10}t_{\rm Q}} = 0.80^{+0.37}_{-0.27}$. Our results allow us to estimate the probability of detecting very young quasars with tQ ≤ 0.1 Myr from their proximity zone sizes yielding $p ({\le}0.1\, {\rm Myr}) = 0.19^{+0.11}_{-0.09}$, which is broadly consistent with recent determination at z ∼ 6.
eVITTA: a web-based visualization and inference toolbox for transcriptome analysis
Authors: Cheng Xuanjin , Yan Junran , Liu Yongxing , Wang Jiahe , Taubert Stefan 
Published: May 2021

AbstractTranscriptome profiling is essential for gene regulation studies in development and disease. Current web-based tools enable functional characterization of transcriptome data, but most are restricted to applying gene-list-based methods to single datasets, inefficient in leveraging up-to-date and species-specific information, and limited in their visualization options. Additionally, there is no systematic way to explore data stored in the largest transcriptome repository, NCBI GEO. To fill these gaps, we have developed eVITTA (easy Visualization and Inference Toolbox for Transcriptome Analysis; https://tau.cmmt.ubc.ca/eVITTA/). eVITTA provides modules for analysis and exploration of studies published in NCBI GEO (easyGEO), detailed molecular- and systems-level functional profiling (easyGSEA), and customizable comparisons among experimental groups (easyVizR). We tested eVITTA on transcriptomes of SARS-CoV-2 infected human nasopharyngeal swab samples, and identified a downregulation of olfactory signal transducers, in line with the clinical presentation of anosmia in COVID-19 patients. We also analyzed transcriptomes of Caenorhabditis elegans worms with disrupted S-adenosylmethionine metabolism, confirming activation of innate immune responses and feedback induction of one-carbon cycle genes. Collectively, eVITTA streamlines complex computational workflows into an accessible interface, thus filling the gap of an end-to-end platform capable of capturing both broad and granular changes in human and model organism transcriptomes.
Functional characterization of RebL1 highlights the evolutionary conservation of oncogenic activities of the RBBP4/7 orthologue in Tetrahymena thermophila
Authors: Nabeel-Shah Syed , Garg Jyoti , Saettone Alejandro , Ashraf Kanwal , Lee Hyunmin , Wahab Suzanne , Ahmed Nujhat , Fine Jacob , Derynck Joanna , Pu Shuye , Ponce Marcelo , Marcon Edyta , Zhang Zhaolei , Greenblatt Jack F , Pearlman Ronald E , Lambert Jean-Philippe , Fillingham Jeffrey 
Published: May 2021

Abstract
Retinoblastoma-binding proteins 4 and 7 (RBBP4 and RBBP7) are two highly homologous human histone chaperones. They function in epigenetic regulation as subunits of multiple chromatin-related complexes and have been implicated in numerous cancers. Due to their overlapping functions, our understanding of RBBP4 and 7, particularly outside of Opisthokonts, has remained limited. Here, we report that in the ciliate protozoan Tetrahymena thermophila a single orthologue of human RBBP4 and 7 proteins, RebL1, physically interacts with histone H4 and functions in multiple epigenetic regulatory pathways. Functional proteomics identified conserved functional links for Tetrahymena RebL1 protein as well as human RBBP4 and 7. We found that putative subunits of multiple chromatin-related complexes including CAF1, Hat1, Rpd3, and MuvB, co-purified with RebL1 during Tetrahymena growth and conjugation. Iterative proteomics analyses revealed that the cell cycle regulatory MuvB-complex in Tetrahymena is composed of at least five subunits including evolutionarily conserved Lin54, Lin9 and RebL1 proteins. Genome-wide analyses indicated that RebL1 and Lin54 (Anqa1) bind within genic and intergenic regions. Moreover, Anqa1 targets primarily promoter regions suggesting a role for Tetrahymena MuvB in transcription regulation. RebL1 depletion inhibited cellular growth and reduced the expression levels of Anqa1 and Lin9. Consistent with observations in glioblastoma tumors, RebL1 depletion suppressed DNA repair protein Rad51 in Tetrahymena, thus underscoring the evolutionarily conserved functions of RBBP4/7 proteins. Our results suggest the essentiality of RebL1 functions in multiple epigenetic regulatory complexes in which it impacts transcription regulation and cellular viability.
Renal dysfunction and podocyturia in pre-eclampsia may be explained by increased urinary VEGF
Authors: Valsecchi Luca , Galdini Alessandro , Gabellini Daniela , Dell’Antonio Giacomo , Galbiati Silvia , Fanecco Andrea , Viganò Ilaria , Smid Maddalena , Bernardi Rosa , Maestroni Silvia , Baelde Hans J , Zerbini Gianpaolo 
Published: May 2021

Abstract

Background
Pre-eclampsia has a major impact on renal function as shown by the development of proteinuria and podocyturia. How the systemic, soluble Fms-like tyrosine kinase-1 (sFlt-1)-driven inhibition of vascular endothelial growth factor (VEGF) activity detected in pre-eclampsia directly affects renal function remains unknown. The aim of the study was to clarify whether a non-canonical, renal-centred escape from VEGF inhibition in the case of pre-eclamptic pregnancy might have a direct impact on renal function.

Methods
We evaluated plasma and urinary VEGF and placental growth factor (PlGF), plasma sFlt-1 and carbonic anhydrase IX (CAIX), albuminuria and podocyturia in 18 women with uncomplicated pregnancy, 21 with pre-eclampsia and 18 non-pregnant. The three groups were matched for age and the pregnant groups also for gestational age at enrolment.

Results
Plasma VEGF was reduced in uncomplicated (P = 0.001) and pre-eclamptic (P = 0.0003) pregnancies when compared with controls. In uncomplicated pregnancy, the dysfunction was balanced by an increase (P = 0.009) of plasma PlGF. Increased (P = 0.0001) plasma CAIX in pre-eclampsia was in line with hypoxia. Pre-eclampsia resulted in a paradoxical increase (P = 0.0004) of urinary excretion of VEGF. Urinary concentrations of VEGF and podocytes were correlated to each other (r2 = 0.48, P &lt; 0.0005) but also to plasma sFlt-1 (r2 = 0.56, P &lt; 0.0001 and r2 = 0.23, P = 0.03, respectively).

Conclusions
In the case of pre-eclampsia, the systemic VEGF inhibition leads the kidney, possibly the podocyte, to increase the VEGF synthesis. The mechanisms leading to local VEGF overproduction or the overproduced VEGF itself are reasonably involved in the pathogenesis of podocyturia and, as a consequence, renal dysfunction in pre-eclampsia.
Professional and Ethical Issues in United States Acute Care Physical Therapists Treating Patients With COVID-19: Stress, Walls, and Uncertainty
Authors: Ditwiler Rebecca E , Swisher Laura L , Hardwick Dustin D 
Published: May 2021

Abstract

Objective
To the authors' knowledge, no peer-reviewed research has explored professional and ethical issues encountered by physical therapists in treating patients with COVID-19. The purpose of this study was to explore the experiences of physical therapists regarding the professional and ethical issues they encountered during the COVID-19 pandemic.

Methods
The current study used reflexive thematic analysis, a qualitative research design developed by Braun and Clarke, to analyze individual interviews.

Results
Analysis of the coded interviews produced 6 primary themes (uncertainty, physical therapist’s role, ethical dilemmas and moral distress, emotions, providing care and working conditions, and management and leadership influence) and associated subthemes.

Conclusion
Physical therapists reported numerous professional and ethical issues across the individual, organizational, and societal realms during the COVID-19 pandemic. This study highlights the need for education and resources to prepare physical therapists for professional and ethical issues encountered during pandemics. Specifically, there is a need to define the physical therapist’s role in pandemics and prepare physical therapy personnel for dealing with ethical issues, stress, uncertainty, and organizational changes associated with pandemics. Ethical guidelines would support organizations in delineating fair processes for triage and allocation of scarce resources for acute care physical therapy during health care emergencies.

Impact
The COVID-19 pandemic has produced significant changes in health care and physical therapist practice. This study reports results of the first, to our knowledge, research study focusing on professional and ethical issues experienced by physical therapists in acute care during the COVID-19 pandemic. As the United States faces an unprecedented spike in COVID-19 cases and deaths, results of this study may contribute to physical therapists’ preparation for and response to professional and ethical issues encountered in acute care during the pandemic.
Management of Vancouver B2 Periprosthetic Femoral Fractures, Revision Total Hip Arthroplasty Versus Open Reduction and Internal Fixation: A Systematic Review and Meta-Analysis
Authors: Lewis Daniel P. , Tarrant Seth M. , Cornford Lachlan , Balogh Zsolt J. 
Published: May 2021

Objective:
To identify and analyze the current evidence for the use of open reduction and internal fixation (ORIF) constructs compared with conventional revision total hip arthroplasty (rTHA) for the management of Vancouver B2 periprosthetic femoral fractures (PFFs).

Data Sources:
A systematic literature search of the MEDLINE, CINAHL, and EMBASE databases was conducted. Prospective and retrospective studies were eligible. No limitation was placed on publication date, with only articles printed in English eligible.

Study Selection:
Included studies were retrospective studies comparing ORIF and rTHA for the management of Vancouver B2 PFFs.

Data Extraction:
The primary outcome was the overall complication rate. Other outcomes included as rate of dislocation, revision operation, refracture, infection, nonunion, and subsidence/loosening. Twenty-four studies were included totaling 1621 patients, of which 331 were treated with ORIF and 1280 with rTHA.

Conclusion:
The 1621 patients included comprised a mixture of different fracture patterns, prostheses, and patient comorbidities. The overall complication rate for ORIF was 24% versus 18% for rTHA (P = 0.13). The results demonstrate that rTHA has a similar revision rate to ORIF in PFFs with a loose femoral component and adequate bone stock. ORIF was superior to rTHA in prevention of postoperative dislocation; however, there was no difference between other complications. This review suggests a potential role of both ORIF and rTHA in the management of Vancouver B2 PFFs.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.