bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decolonizing Health in Canada: A Manitoba First Nation Perspective
Authors: Eni Rachel , Beck Wanda Phillips , Achan Grace Kyoon , Lavoie Josée G. , Kinew Kathi Avery , Katz Alan 
Published: February 2021

Abstract
Background

This paper focuses on a longitudinal research program in Manitoba, Canada, by the Innovation Supporting Transformation in Community-Based Research Project (iPHIT) to learn from First Nations across the province that have developed effective community-based primary healthcare models. The research is relevant and timely as First Nations across the country, and Indigenous populations globally, work towards improvements in population health and health equity via critical analysis and restructuring of health services. The purpose of the paper is to deepen an understanding of decolonization as it is defined within the communities, as a central aspect of health restructuring.
Methods

The study is a qualitative, grounded theory analysis, which is a constructivist approach to social research that allows for generation of theory in praxis, through interactions and conversations between researchers and research participants. Findings are based on 183 in-depth interviews and eight focus group discussions with participants from 8 Manitoba First Nation communities. The study was designed to understand strengths, limitations and priorities of primary healthcare strategies and frameworks of the communities. The iPHIT team was an active collaborative partnership between the First Nation communities, First Nation Health and Social Secretariat of Manitoba, and the University of Manitoba. The First Nation partners led in all aspects of the research, from development to implementation, data collection, analyses, and dissemination. Respected Elders from the communities also guided in appropriate research and engagement protocols.
Results

Data was coded and then grouped into 4 interconnecting themes. These are: (1) First Nation control of healthcare, (2) traditional medicine and healing activities, (3) full community participation, and (4) moving out of colonization involves cleaning up and moving beyond the mess that colonization has inflicted.
Conclusion

Decolonizing health involves a taking back of Indigenous wisdom and traditional activities; connections to the land, resources; intra- and inter-community relationships. Participants emphasized the value of full community engagement with respect to inclusion of different interpretations of and experiences in the world, highlighting creation of a shared vision. The study focused on First Nation community experiences and interests in Manitoba specifically, though the data may be applicable to national and global decolonization efforts.
Parainfectious Guillain Barre Syndrome in a Patient Diagnosed with COVID-19
Authors: Bastug Aliye , Bektas Hesna , Buyuktarakci Cansu , Bodur Hurrem 
Published: February 2021

Abstract
An accumulating evidence suggesting the neurotropic characteristics of the SARS-CoV-2. Although the pathogenesis is unclear, the relationship between COVID-19 and Guillain Barre Syndrome(GBS) has been previously reported. We present a 66-year-old male with para- infectious COVID-19-related GBS admitted with a 2-day bilateral weakness in distal lower limbs. His neurological findings occurred on the third day of the diagnosis of COVID-19. A cerebrospinal fluid examination revealed albumin-cytological dissociation.To the best of our knowledge, this is the first para-infectious GBS case related to the SARS-CoV-2 reported from Turkey. Clinicians should be aware of this kind of complication to manage patients.
Hierarchical flower-like ZnO-Ag@Cellulose composite with antifouling and antibacterial properties for efficient recovery of tellurium (IV) from wastewater
Authors: Yao Guanglei , Shao Xue , Qiu Zhiwei , Qiu Fengixan , Zhang Tao 
Published: February 2021

Abstract
Recovery of the tellurium from wastewater is significance for both industrial applications and sustainable development due to the adverse impacts emanating from environmental pollution and strategic values in the photovoltaic industry. Herein, this study presents the recovery of tellurium from wastewater by flower-like structure ZnO-Ag@cellulose (ZAC) composites. For adsorbent preparation, lignocellulose was first extracted from waste wood debris by an alkaline extraction process. Then, the flower-like structure of ZAC composites were synthesized by a facile one-step hydrothermal method. The obtained materials are conducted under different parameters to investigate tellurium adsorption properties. The results indicate that the tellurium adsorption process is an exothermic reaction and fits well to the Freundlich model. Kinetic data are well described by pseudo-second-order model, indicating ZAC adsorption of tellurium is a chemical process. Besides, as-prepared ZAC exhibited excellent performance for tellurium elimination from wastewater with a maximum removal efficiency of 98.86%. The ZAC also shows outstanding antifouling performance in polluted environment and can still achieve the rate of 94.23% for tellurium. Moreover, the ZAC composite reveals high reusability and stability after six desorption-regeneration cycles. Importantly, the ZAC composite exhibits disinfection performance against E. coli and S. aureus with high killing efficiency. Therefore, this work not only demonstrates ZAC composite is efficient adsorbent with antifouling and antibacterial capability for tellurium recovery, but also provides an effective channel for promising candidates to decontaminate similar pollutants and practical applications of wastewater.
A Novel Bilayer Propionyl-L-carnitine Loaded Polyvinyl Alcohol/Calcium Alginate/Carboxymethyl Cellulose wound dressing for the treatment of diabetic wounds: an in vitro and in vivo study
Authors: Jiang Wenjun , Huang Zuoyao , Min Weixiang , Zhang Hao 
Published: February 2021

Abstract
In the current study a drug delivering bilayer porous/nanofibrous wound dressing was developed using a combination of electrospinning and freeze-drying methods. The wound dressings were prepared by lyophilization of 1:1 weight ratios of calcium alginate and carboxymethyl cellulose (CMC) solutions. Drug delivering nanofibrous sheets were fabricated by electrospinning of polyvinyl alcohol (PVA) solution incorporated with 1%,3%,5%, and 10% of Propionyl-L-carnitine. The dressings were studied regarding their microstructure, swelling capacity, mechanical strength, surface wettability, water vapor permeability, drug release profile, in vitro degradation, cell viability assay, hemocompatibility, porosity measurement, microbial penetration assay, and protein adsorption assay. Based on in vitro studies, PVA sheets loaded with 5% Propionyl-L-carnitine was chosen for the preparation of wound dressings. The healing potential of the produced constructs was studied in rat model of diabetic wound. Our results showed that the drug delivering dressings demonstrated significantly higher wound closure and better histological regeneration compared to drug free constructs and sterile gauze. Our results suggest potential applicability of Propionyl-L-carnitine delivering Calcium Alginate/CMC/PVA dressing for the treatment of diabetic wounds in clinic.
HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML
Authors: Li Zheng , Wang Fangce , Long Jun , Zhang Wenjun , Xu Jun , Liang Aibin 
Published: February 2021

Abstract
Background: Leukaemia stem cells (LSCs) are responsible for the initiation, maintenance, and recurrence of acute myeloid leukaemia (AML), an aggressive haematological malignancy associated with drug resistance and relapse. Identifying therapeutic LSC targets is critical to curing AML.Methods: Bioinformatics databases were used to identify therapeutic LSC targets. The conditional knockout mice were used to analyse the role of HCK in leukaemogenesis or normal haematopoiesis. Colony-forming assays, cell counting, and flow cytometry were used to detect the viability and function of leukaemia cells. RT-PCR, western blotting, and RNA sequencing were used to detect mRNA and protein expression.Result: ﻿HCK is expressed at higher levels in LSCs than in haematopoietic stem cells (HSCs), and high HCK levels are correlated with reduced survival time in AML patients. Knockdown of HCK leads to cell cycle arrest, which results in a dramatic decrease in the proliferation and colony formation in human AML cell lines. Moreover, HCK is ﻿required for leukemogenesis﻿ and leukaemia maintenance in vivo and in vitro. HCK is necessary for the self-renewal of LSCs during serial transplantation and limiting dilution assay. The phenotypes resulting from HCK deficiency can be rescued by CDK6 overexpression in the human cell line. RNA sequencing and gene expression have demonstrated that HCK may sustain cell cycle entry and maintain the self-renewal ability of LSCs through activating the ERK1/2-c-Myc-CDK6 signalling axis. In contrast, ﻿HCK deletion does not affect normal haematopoiesis or haematopoietic reconstruction in mice.Conclusion: HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML and may be an ideal therapeutic target for eradicating LSCs without influencing normal haematopoiesis.
Identification of Canine Brucellosis in Three Province, Ethiopia
Authors: Girmay Aregawi , Sisay Atitegeb , Belete Shiret 
Published: February 2021

Abstract
Background: In Ethiopia, brucellosis has been reported targeted on bovine, occasionally on shoat, and rarely on camels. An investigation of the disease Brucellosis in the neglected companion animals is scared in Ethiopia. The objective of this study was to identify canine brucellosis in Batu town, Alage and Naka village through cross sectional approaches. A total of 389 serum samples (207 from Batu, 107 from Alage, and 75 from Naka) were collected by restraining dogs with a portable and safe modified dog crush, invented by this author. Blood samples were collected from ear vein and sera were screened for Brucella antibodies using different serological tests. RBPT prepared from the smooth strain B. abortus antigen and CFT was used as a screening test and confirmatory test, respectively. Furthermore, all sera samples had also screened by RBPTcanis antigen (rough strain); and those positive were considered the cause for B. canis infection. Results: Using RBPT smooth strains, 21(5.4%; CI: 3.35, 7.96) were positive and 19(4.88%; CI: 2.7, 7.0) were confirmed by CFT. Besides, 34 (8.74%; CI: 5.92, 11.56) were positive for RBPTcanis rough strains. Relatively, higher proportion of anti B. canis antibodies had seen in Batu (11.59%) followed by Alage (5.61%), and Naka (5.33%). Sex, living condition, and history of obstetrical problem were significantly associated with the occurrence of canine brucellosis (p< 0.05). Odd of canine brucellosis due to smooth and rough strains in outdoor dogs were 4.72 and 6.42 times higher compared with indoors, respectively. This is true the fact that outdoors had a chance of getting infected aborted wastes when roaming freely. Conclusion: This study suggests that canine brucellosis is prevalent in the province. The seropositivity could give an insight that, the awareness of the people toward the disease was also the gap in the study area. Hence, this warrants public education among the community is recommended.
A correlational study of reproductive concerns with self-disclosure and mental resilience in breast cancer patients of childbearing age in China
Authors: Yu Ya , Ye Yanxin , Liu Suting , Zhang Lili 
Published: February 2021

Abstract
ObjectiveThe current study aimed to investigate the prevalence of reproductive concerns in breast cancer patients of Chinese women of childbearing age, to explore the effects of self-disclosure and mental resilience on reproductive concerns, and to explore the relationships among the three variables. MethodsCorrelation research design was used.274 women suffering from breast cancer with age (M=38.10, SD=6.44) were taken from two tertiary hospitals in Guangzhou. The participants were asked to fill out a set of self-reported questionnaires including the Sociodemographic data, Reproductive Concerns after Cancer scale (RCACs), the Distress Disclosure Index (DDI), and the 14-Item Resilience scale (RS-14). The mediation analysis was tested using SPSS (Process-plugin) and the bootstrap method. ResultsA total of 252 valid questionnaires were collected in this study. 36.1% of the patients scored highly in at least one dimension of reproductive concerns, with Child's health and Personal health being the top two concerns. Correlation analysis revealed that there was a significant positive relationship between self-disclosure and mental resilience. Self-disclosure and mental resilience had a negative relationship with reproductive concerns, respectively. The results of the mediation analysis showed that there was a mediational role of mental resilience between self-disclosure and reproductive concerns. ConclusionIt was concluded that breast cancer patients with high levels of self-disclosure, are more resilient and have fewer reproductive concerns.
The Characteristics, Related Factors and Risk Factors of Insomnia among Postoperative Patients with Gastric Cancer: A Cross-sectional Survey
Authors: Zhu Guang-hui , Li Juan , Li Jie , Xu Bo-wen , Wang He-ping , Wang Xin-miao , Hu Jia-qi , Dai Ming-hao 
Published: February 2021

Abstract
Purpose

This study aims to explore the characteristics, related factors and risk factors of insomnia of patients after operation for gastric cancer.
Methods

A cross-sectional survey was carried out and finally 115 patients with insomnia after operation for gastric cancer were included. The general information, gastric cancer related information, sleep quality and other symptoms were investigated.
Results

①The Pittsburgh sleep quality index score of most insomnia patients after gastric cancer surgery was 11–15 points, the sleep quality rating was “Poor”. ②The sleep quality of patients with insomnia after surgery for gastric cancer is related to the number of chemotherapy cycles, fatigue and depression. ③The risk of reduced sleep quality with the number of chemotherapy cycles > 6 is 3.640 times that of ≤ 6. The risk of reduced sleep quality during moderate to severe fatigue was 4.390 times that of patients with no or mild fatigue.
Conclusion

Attention to related factors and risk factors may be associated with improvement of sleep quality in patients with gastric cancer after surgery.
Prevalence of Depression and Associated Relationship with Lifestyles in Chinese Adults with Multi-Level Generalized Estimation Equation Model
Authors: Yuan Li , Xu Tao , Han Shaomei 
Published: February 2021

Abstract
BackgroundMost epidemiological surveys paid more attention to the occurrence of depression in the elderly and adolescents, while ignored the young and middle-aged people. Besides, depression resulted from a complex interaction of heredity, biochemistry, social, psychological and biological factors. The aim of our study was to examine the prevalence of depression and the relationship between depression and lifestyle factors in Chinese adults based on a large-scale cross-sectional survey. MethodsThe Composite International Diagnostic Interview Short Form for Major Depression was used to assess the depression status of all subjects. We used multi-level generalized estimating equation model to determine the relationship between depression and lifestyles. ResultsOf the 7985 respondents, 4252 were considered as being depressive with a prevalence of 53.25%. After controlling for the cluster effect of living environment and confounding effect of demographic characteristics, the following factors increased the risk of depression: overweight(OR=1.269, 95% CI: 1.117-1.444), obesity(OR=1.415, 95%CI: 1.152-1.740), single status(OR=2.003, 95% CI: 1.635-2.457), alcohol drinking(OR=1.333, 95%CI: 1.137-1.563), sleeping less than 6h a day(OR=1.485, 95% CI: 1.267-1.743), poor sleep quality (OR=1.553, 95% CI: 1.392-1.732), feeling stressed(OR=2.133, 95% CI: 1.744-2.621), adverse life events(OR=1.513, 95% CI: 1.333-1.718),unhealthy dietary patterns(OR=1.472, 95% CI: 1.324-1.638), irregular meal times (OR=2.482, 95% CI: 2.138-2.887) and suboptimal health status(OR=7.919, 95% CI: 6.843-9.185). Those with medical insurance (OR=0.774, 95% CI: 0.649-0.921) was less likely to have depression.ConclusionsUnhealthy lifestyles were found closely associated with depression. By altering lifestyle behaviors for the better, the depressive symptoms could be effectively improved.
Diversity Loss and Restructuring of the Microbiota in a Globally Invasive Lady Beetle&nbsp;&nbsp;
Authors: Li Hongran , Shu Xiaohan , Zhou Jinchen , Meng Ling , Zhou Xuguo , Obrycki John , Li Baoping 
Published: February 2021

Abstract
The invasion success of Harmonia axyridis in North America and Europe has aroused a growing interest among students of invasion biology. This study was focused on the microbial community of H. axyridis with the aim of gaining insights into their potential roles in the invasion. We hypothesized that microbial communities of H. axyridis in the non-native range may decrease in diversity but restructured in composition as compared to those in the native regions. We collected lady beetle samples from eleven geographical areas across the native range mainland China and from seven areas in the non-native range USA. We applied next-generation amplicon sequencing to the samples to estimate microbial communities and examined differences in their composition and diversity between the host’s native and non-native ranges. We found that H. axyridis in the non-native range had lower microbial community richness and evenness than it had in the native range, but its microbiota composition of the amplicon sequence variants and genera differed markedly between the non-native and native ranges. The findings support our hypotheses concerning microbial community in H. axyridis across the native and non-native range. This study provides new information for our understanding of potential roles of the microbiota in the invasion success of H. axyridis.
Clinical analysis of mifepristone combined with transabdominal ultrasound-guided suction and curettage for different types of scar pregnancy
Authors: Lian Hongmei , chen dejun , Zheng Jingxia , Zhang Ling 
Published: February 2021

Abstract
Background

Cesarean scar pregnancy (CSP) is a life-threatening condition without consensus on treatment. The purpose of this study was to evaluate the safety, efficacy, and outcome of mifepristone combined with transabdominal ultrasound-guided suction and curettage (TUSC) in the treatment of CSP.
Methods

CSP patients who treated with mifepristone combined TUSC at Maternal and Child Hospital of Hubei Province from 2013 to 2015 was retrospectively analyzed. Patients were divides into three types based on the newest classification criteria in China. Clinical information and outcomes were analyzed.
Results

157 CSP patients were included, with 96 type I cases, 56 type II cases and 5 type III cases. No significant differences in age, gravity, parity, gestational age and initial β-human chorionic gonadotropin (β-hCG) levels among the three types. All patients were successfully treated with mifepristone combined with TUSC. No one needed emergency blood transfusion or another treatment. After mifepristone combined with TUSC treatment, the percentage changes of the β-hCG levels were similar in all CSP types. The average of intraoperative blood loss in type I patients during suction curettage was lower than in type II and type III, and more Foley catheters were inserted into the uterus in type II and type III than type I patients to achieve hemostasis.
Conclusion

Mifepristone combined with TUSC appears to be a safety and efficacy treatment option to all types of CSP.
Logarithmic Spiral Gear Design And Production Of With The 3D-Printer
Authors: Yazar Mehmet 
Published: February 2021

Abstract
In this study, a software has been developed for parametric design and modeling of logarithmic spiral gears and gear pairs, which are a member of non-circular gears, using complex numbers in the CAD (Computer Aided Design) environment. In software development, the widely used AutoLISP programming language, a software programming language specially designed for AutoCAD, was used. In the program, parameters such as modules and number of teeth are entered by the user interactively, and the design and modeling of logarithmic spiral gears in the AutoCAD environment is performed automatically. The production of this designed gear pair has been completed with a 3D printer. This work contributes to the designer for the functional and precise production of logarithmic spiral gears to the design and manufacture of these gears. This work contributes to the designer and manufacturer in the functional and precise design and production of logarithmic spiral gears.
Use of geographical information systems in multiple sclerosis research: A systematic scoping review
Authors: Hashtarkhani Soheil , Tabatabaei-Jafari Hossein , Kiani Behzad , Furst MaryAnne , Salvador-Carulla Luis , Bagheri Nasser 
Published: February 2021

Abstract
Introduction: Geographical Information System (GIS) and spatial analysis have an emerging role in the understanding and management of health-related outcomes. However, there is a knowledge gap about the extent to which GIS has supported Multiple Sclerosis (MS) research. Therefore, this review aimed to explore the types of GIS applications and the complexity of their visualisation in MS research. Methods: A systematic scoping review was conducted based on York’s five-stage framework. PubMed, Scopus and Web of Science were searched for relevant studies published between 2000 and 2020 using a comprehensive search strategy based on the main concepts related to GIS and MS. Grounded, inductive analysis was conducted to organize studies into meaningful application areas. Further, we developed a tool to assess the visualisation complexity of the selected papers.Results: Of 3,723 identified unique citations, 42 papers met our inclusion criteria for the final review. One or more of the following types of GIS applications were reported by these studies: (a) thematic mapping (37 papers); (b) spatial cluster detection (16 papers); (c) risk factors detection (16 papers); and (d) health access and planning (two papers). In the majority of studies (88%), the score of visualisation complexity was relatively low: three or less from the range of zero to six. Conclusions: Although the number of studies using GIS techniques has dramatically increased in the last decade, the use of GIS in the areas of MS access and planning is still under-researched. Additionally, the capacity of GIS in visualising complex nature of MS care system is not yet fully investigated.