bluuebunny/crossref_metadata_2025_split huggingface dataset:
The albumin to globulin ratio is associated with mucosal healing in Japanese patients with ulcerative colitis: A cross-sectional study
Authors: Yagi Sen , Furukawa Shinya , Shiraishi Kana , Hanayama Masakazu , Tange Kazuhiro , Hashimoto Yu , Kitahata Shogo , Mori Kenichirou , Ninomiya Tomoyuki , Suzuki Seiyuu , Shibata Naozumi , Murakami Hidehiro , Ohashi Katsuhisa , Yano Makoto , Hasebe Aki , Tomida Hideomi , Yamamoto Yasunori , Takeshita Eiji , Ikeda Yoshio , Hiasa Yoichi 
Published: January 2021

Abstract
Background

Ulcerative colitis (UC) is a chronic inflammatory disease. Mucosal healing (MH) is inversely associated with clinical outcome. The albumin to globulin ratio (AGR) is known as chronic inflammation marker. While some evidence regarding an association between AGR and some chronic diseases has been reported, no evidence regarding association between AGR and UC exists. The aim of this study to evaluated the association between AGR and MH among Japanese patients with UC.
Methods

The study subjects consisted of 273 Japanese patients with UC. AGR was divided into quartiles on the basis of the distribution of all study subjects. One endoscopic specialist was responsible for evaluating MH, which was defined as a Mayo endoscopic subscore of 0 or 0–1. Age, sex, steroid use, body mass index, age at onset of UC, and anti-TNFα preparation were selected a priori as potential confounding factors.
Results

The mean age was 51.2 years, and the percentage of male patients was 59.0%. The percentage of MH was 26.4%. High AGR (1.483 < AGR ≤ 1.643) and very high AGR (> 1.643) was significantly positively associated with MH (OR 2.21 [95% CI: 1.12–4.47], p for trend = 0.001) after adjustment for confounding factors. No association between AGR and partial MH was found. The independent positive association between AGR and MH was found in only low C-reactive protein group.
Conclusion

Among Japanese patients with UC, AGR was significantly positively associated with MH, was significantly positively associated with MH especially in the low C-reactive protein group.
Association Between Interleukin-12 and Sarcopenia
Authors: Chen Yuan-Yuei , Kao Tung-Wei , Chiu Yi-Lin , Peng Tao-Chun , Yang Hui-Fang , Chen Wei-Liang 
Published: January 2021

Abstract
Background: Emerging studies have proposed that cytokines secreted following macrophage polarization may contribute to skeletal muscle aging. The current study primarily aimed to determine whether these cytokines have impact on the progression of sarcopenia in an elderly population.Methods: Overall, 120 elderly adults aged 65 years and older who underwent health examinations from 2015 to 2019 were included in this retrospective study. Sarcopenia was based on the criteria proposed by the European Working Group on Sarcopenia in Older People in 2019. Macrophages and cytokines datasets were obtained from Gene Expression Omnibus (GEO) database. Comprehensive assessments were performed for muscle strength, muscle mass, gait speed, tumor growth factor-β (TGF-β), and interleukin-12 (IL-12). Thereafter, the association between sarcopenia and cytokines were analyzed using regression models.Results: Low muscle strength and low speed gait were negatively associated with IL-12 [β: -8.96 (95%CI: -14.12, -3.79) and -7.16 (95%CI: -12.54, -1.78), respectively]. Participants with more sarcopenia components and more severe sarcopenia had lower IL-12 (P for trend < 0.001). Conversely, more sarcopenia components were associated with increased TGF-β (P for trend < 0.05). A definite diagnosis of sarcopenia was associated with decreased IL-12 and increased TGF-β with β of -8.96 (95%CI: -14.12, -3.79) and 147.75 (95%CI: 36.27, 259.23). Furthermore, increased IL-12 levels were significantly associated with reduced occurrence of sarcopenia with and odd ratio (OR) of 0.36 (95%CI: 0.15-0.834).Conclusion: Our findings on the relationship between cytokines and age-related muscle loss showed that IL-12 may be an early diagnosis indicator for sarcopenia in the elderly population.
Return to Work in the Gastric Cancer Survivors
Authors: Chen Yuan-Yuei , Chen Wei-Liang , Wu Wei-Te , Ho Ching-Liang , Wang Chung-Ching 
Published: January 2021

Abstract
Returning to work (RTW) is an often used outcome in work research to describe employee fully recovering from disease. Several factors are suggested as barriers for workers returning to work. The goal of this study was to investigate the role of RTW in workers with gastric cancer and identify its impact on their survival outcomes during 11 years of follow-up. A total of 4467 workers who with newly diagnosis of gastric cancer were included in this retrospective cohort study with a follow-up period ranging from 2004 to 2015. Relationships between work, treatment, and disease-related variables and RTW were analyzed by Cox regression. The impact of RTW on survival outcomes was analyzed by Kaplan-Meier survival curves. Old age, males, comorbidities, chemotherapy, radiotherapy, and manual jobs were inversely associated with RTW. Operation and early stage of gastric cancer were associated with increased likelihood of RTW. After adjusting for variables, workers with stage 1 gastric cancer were more likely return to work than other stages with HR of 4.67 (95%CI: 2.99~7.31) and 7.44 (95%CI: 4.12~13.43) in the 2nd and 5th year. In terms of effect of RTW on survival rate, reemployed workers had better survival than those without employment in all gastric cancer survivors. Furthermore, RTW had significant association with reduced risk of all-cause mortality (HR: 0.49, 95%CI: 0.38~0.65). Improving these identified barriers and strengthening facilitators of RTW can provide employers and government to conduct comprehensive employment plans for increasing the percentage of RTW in the gastric cancer survivors.
Gene Mutation Characteristics and Cluster Analysis of Multidrug-Resistant Mycobacterium Tuberculosis in Urumqi
Authors: Yang Jiandong , Yadikaer Rayibai , Chen Yanggui , Ma Li , Lu Yaoqin , Xue Na , Rui Baolin 
Published: January 2021

Abstract
Objective To understand the molecular biological characteristics of multidrug-resistant Mycobacterium tuberculosis in Urumqi by the analysis of gene mutation and clustering of multidrug-resistant Mycobacterium tuberculosis in Urumqi, to provid theoretical basis for the prevention and control of multidrug-resistant tuberculosis in the future. Methods The tuberculosis patients who were diagnosed, registered, cultured positive Mycobacterium tuberculosis and over 16 years old in Urumqi were studied. Geno Type MTBDR plus Assay and MIRU-VNTR were used to analysis the gene mutation and clustering of multidrug-resistant mycobacterium tuberculosis in Urumqi. Result Mutation gene included Isoniazid resistance gene katG 315; Rifampicin resistance gene rpoB 526, 531; Ethambutol resistance gene embB 206; Streptomycin resistance gene rpsL 43 and RRs 1401; Ofloxacin resistance gene gyrA 74, 90, 91 and 94. It was shown that the Beijing genotype was predominant (49.530%) among these319strains. There were 14 strains multi-drug resistant strains, it was predominant (73.684%) of multi-drug resistant strains. Multi-drug resistant prevalence of Beijing strains was 8.861%. The clustering rate of MDR-TB was 5.263% in Urumqi. Conclusion Molecular biological characteristics of multidrug-resistant Mycobacterium tuberculosis have some particularities in Urumqi. Therefore, modern molecular epidemiological techniques such as molecular biology and DNA fingerprinting can be used to improve the speed of diagnosis and to carry out case tracking and source investigation.
Smooth Transportation of Liquid Metal Droplets in a Microchannel as Detected by a Serially Arranged Capacitive Device
Authors: Konishi Satoshi , Kakehi Yuugo , Mori Fuminari , Bono Shinji 
Published: January 2021

Abstract
Gallium alloy liquid metals (Ga-LMs) possessing fluidity, electric conductivity, and low toxicity are attractive for use in flexible devices and microfluidic devices. However, the oxide skin of Ga-LMs in the atmosphere adheres to the microchannel surface, preventing the transportation of Ga-LMs in the channel. We introduced liquid with Ga-LMs into a channel with a radius of 500 µm to prevent the oxide skin of the Ga-LM from adhering to the channel. Then, we found that the cylindrical shape of the channel enabled smooth transportation of Ga-LMs independently of both the liquid and the channel material. The liquid introduced with Ga-LMs not only prevents adhesion but also improves the spatial controllability of Ga-LMs in the channel. We can control the position of Ga-LMs with 100 µ m resolution using highly viscous (> 10 cSt) liquid. In addition, we combined the microchannel with patterned electrodes, fabricating a serially arranged capacitive device. The local capacitance detected by the patterned electrodes changed by more than 6 % via the smooth transportation of Ga-LMs. The analysis results based on an equivalent circuit quantitatively agree with our experimental results. We can modulate the serially arranged capacitors using the smooth transportation of Ga-LMs in the channel.
Chromosome 10 Abnormality Predicts Prognosis of Neuroblastoma Patients With Bone Marrow Metastasischromosome 10 Abnormality Predicts Prognosis of Neuroblastoma Patients With Bone Marrow Metastasis
Authors: Jiang Chiyi , Xu Xiao , Jian Binglin , Zhang Xue , Yue Zhixia , Guo Wei , Ma Xiaoli 
Published: January 2021

Abstract
Background Neuroblastoma (NB) is the most common extracranial solid tumor in children with high heterogeneity and concealed onset. The mechanism for its occurrence and development has not been revealed. The purpose of this study was to summarize the clinical characteristics of children with NB and abnormal chromosome 10. To investigate the relationship between the number and structure of chromosome 10 abnormality and NB prognosis.MethodsWe used chromosome G-banding in the first diagnosis to evaluate the genetics of chromosomes in patients with NB, and follow up their clinical characteristics and prognosis. All participants were diagnosed with NB in Hematology Oncology Center, Beijing Children’s Hospital from May 2015 to December 2018, and were followed up for at least one year. ResultsOf all 150 patients with bone marrow metastases, 42 were clearly diagnosed with chromosomal abnormalities. There were 13 patients with chromosome 10 abnormalities definitely, and the loss of chromosome 10 was the most common decrease in the number of chromosomes. These 13 patient had higher LDH, lower OS and EFS than that of children in abnormal group without chromosome 10 abnormality. Eight patients both had MYCN amplification and 1p36 deletion. Two of them had optic nerve damage and no vision, and 1 had left supraorbital metastases five months after treatment. Among the 16 children with suspected chromosome 10 abnormalities, 3 also had orbital metastases. ConclusionsThe above results showed that chromosome 10 might be a new prognostic marker. MYCN amplification and 1p36 deletion may be related with chromosome 10 abnormalities in NB. And NB patients with abnormal chromosome 10 were prone to have orbital metastases.
Research on Application of Bakri Balloon Tamponade in Treatment of 169 Cases of Postpartum Hemorrhage
Authors: Yang Hui , Cao Mei Dong , zhao yun , Sun Qiang Guo , Cheng Yao 
Published: January 2021

Abstract
Background: To acquire a better understanding of application effect, advantages and disadvantages of Bakri balloon tamponade in treatment of postpartum hemorrhage, and explore the appropriate pathological occasion and optimal timing for placing Bakri balloon.Methods: A retrospective study which used Bakri balloon for postpartum hemorrhage was conducted from January 1, 2016 to December 31, 2019 in our hospital .Results: There were 169 patients who treated with Bakri balloon tamponade, no detachment occurred after Bakri balloon cervical forceps clipped with toothless oval forceps. There were 148 cases of successful balloon tamponade hemostasis, accounting for 87.6%，and 21 failure cases, accounting for 12.4%. The failure rate of balloon tamponade hemostasis significantly increased in the case of over 1500ml bleeding. In the failure group, placental adhesion and accreta accounted for 57.1% (12/21), and placental implantation was found an important factor causing balloon tamponade hemostasis failure.Conclusion: Cervical forceps clipped with toothless oval forceps can effectively prevent the failure of hemostasis due to balloon prolapse. When postpartum hemorrhage reaches 1500ml and/or placenta accreta is carried out, failure rate of balloon tamponade hemostasis will increase significantly. Nevertheless, it could be used as a temporary measure for less hemorrhage volume and more time toward further treatment.
Information and Communication Technology in Organizational Operations. Ethical and Operational Implications
Authors: Karaoulanis Andreas , Karaoulanis Alexandros–Christos 
Published: January 2021

Authors:
Andreas Karaoulanis,
PhD, MBA, MScENG, MSc, BEng, Business consultant, Thessaloniki, Greece; Honorary Professor of Business Management for PhD candidates at IMSR center, India
Alexandros–Christos Karaoulanis,
High School student, Thessaloniki, Greece

Pages: 6-13

Language: English

DOI: https://doi.org/10.21272/bel.4(4).6-13.2020

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Abstract

In this paper, we discuss Information and Communication technology in terms of knowledge dissemination, not only inside the organization but also how it interacts with the surroundings via such systems. The open systems theory and the stakeholder theory as integral parts of the organization’s operations are briefly examined as their importance is a factor that needs to be taken under consideration in terms of applying Information and Communication Technology. Leadership and how it is exercised throughout the implementation and operation of such systems is another paragon that is discussed, while ethical considerations might arise from the misuse of them. Finally, another significant paragon for the organizational sustainability, the value creation for both the customers and the organization is discussed under the prism of the Information and Communication Systems used in the company in question. The implications of this paper are important as it can be seen as the springboard towards bigger research on the topic of Information and Communication Systems and their societal and organizational implication. Another part that needs to be examined is the leadership approach of the whole process as there are ethical considerations that increase day by day, especially in large corporations. These considerations need to be addressed clearly and in-depth and need to abide by the stakeholder theory to create better societies in the future.

Keywords: ICT, Leadership, Knowledge, Operations, Open Systems Theory, Stakeholder Theory, Ethics, Society.
The Flora Motif as Design Identity in Local Traditional Block Batik
Authors: Kari Rabiatuadawiyah , Samin Mohd Azhar , Legino Rafeah 
Published: January 2021

This study discusses that floral motifs as the dominant traditional motifs in Malaysian block batik. In the 20th century, the block makers created any motif with purpose—the traditional block batik motifs not revealed due to lack of secure identity upon the development of high-tech modernisation. Based on the sequence of this issue, this study aims to classify the various types of local block motifs and designs. The classification base on their features using a suitable procedure. The crucial outcomes where the motifs of block batik still show the elements and innovation of the local motif identity.
Keywords: Block Batik; Design; Motif; Identity
eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bsby e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v5iSI3.2542
Students’ Perspectives of Postgraduate Supervision: Desirable and undesirable practices
Authors: Sidhu Gurnam Kaur , Lim Peck Choo , Teoh Sian Hoon , Muthukrishnan Priyadarshini 
Published: January 2021

The current global completion rate for postgraduates stands at 60 per cent, and one of the main problems cited is poor supervisory practices among postgraduate supervisors. Therefore, this qualitative study presents the views of nine PhD scholars on postgraduate supervisory practices from four universities in Malaysia. The thematic qualitative analysis categorized the supervisory practices into three main aspects, namely desirable, undesirable, and appalling practices. The findings of this study though not conclusive do shed some light on current supervisory practices. The findings imply that training and perhaps the call for accreditation of postgraduate supervisors is in order.
Keywords: postgraduate study; supervisory practices; feedback; learning community; Supervisor-student interaction.
eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v5iSI3.2555
Using Machine Learning to Collect and Facilitate Remote Access to Biomedical Databases: Development of the Biomedical Database Inventory
Authors: Rosado Eduardo , Garcia-Remesal Miguel , Paraiso-Medina Sergio , Pazos Alejandro , Maojo Victor 
Published: January 2021

Background
Currently, existing biomedical literature repositories do not commonly provide users with specific means to locate and remotely access biomedical databases.

Objective
To address this issue, we developed the Biomedical Database Inventory (BiDI), a repository linking to biomedical databases automatically extracted from the scientific literature. BiDI provides an index of data resources and a path to access them seamlessly.

Methods
We designed an ensemble of deep learning methods to extract database mentions. To train the system, we annotated a set of 1242 articles that included mentions of database publications. Such a data set was used along with transfer learning techniques to train an ensemble of deep learning natural language processing models targeted at database publication detection.

Results
The system obtained an F1 score of 0.929 on database detection, showing high precision and recall values. When applying this model to the PubMed and PubMed Central databases, we identified over 10,000 unique databases. The ensemble model also extracted the weblinks to the reported databases and discarded irrelevant links. For the extraction of weblinks, the model achieved a cross-validated F1 score of 0.908. We show two use cases: one related to “omics” and the other related to the COVID-19 pandemic.

Conclusions
BiDI enables access to biomedical resources over the internet and facilitates data-driven research and other scientific initiatives. The repository is openly available online and will be regularly updated with an automatic text processing pipeline. The approach can be reused to create repositories of different types (ie, biomedical and others).
Demystifying the Dark Web Opioid Trade: Content Analysis on Anonymous Market Listings and Forum Posts
Authors: Li Zhengyi , Du Xiangyu , Liao Xiaojing , Jiang Xiaoqian , Champagne-Langabeer Tiffany 
Published: January 2021

Background
Opioid use disorder presents a public health issue afflicting millions across the globe. There is a pressing need to understand the opioid supply chain to gain new insights into the mitigation of opioid use and effectively combat the opioid crisis. The role of anonymous online marketplaces and forums that resemble eBay or Amazon, where anyone can post, browse, and purchase opioid commodities, has become increasingly important in opioid trading. Therefore, a greater understanding of anonymous markets and forums may enable public health officials and other stakeholders to comprehend the scope of the crisis. However, to the best of our knowledge, no large-scale study, which may cross multiple anonymous marketplaces and is cross-sectional, has been conducted to profile the opioid supply chain and unveil characteristics of opioid suppliers, commodities, and transactions.

Objective
We aimed to profile the opioid supply chain in anonymous markets and forums via a large-scale, longitudinal measurement study on anonymous market listings and posts. Toward this, we propose a series of techniques to collect data; identify opioid jargon terms used in the anonymous marketplaces and forums; and profile the opioid commodities, suppliers, and transactions.

Methods
We first conducted a whole-site crawl of anonymous online marketplaces and forums to solicit data. We then developed a suite of opioid domain–specific text mining techniques (eg, opioid jargon detection and opioid trading information retrieval) to recognize information relevant to opioid trading activities (eg, commodities, price, shipping information, and suppliers). Subsequently, we conducted a comprehensive, large-scale, longitudinal study to demystify opioid trading activities in anonymous markets and forums.

Results
A total of 248,359 listings from 10 anonymous online marketplaces and 1,138,961 traces (ie, threads of posts) from 6 underground forums were collected. Among them, we identified 28,106 opioid product listings and 13,508 opioid-related promotional and review forum traces from 5147 unique opioid suppliers’ IDs and 2778 unique opioid buyers’ IDs. Our study characterized opioid suppliers (eg, activeness and cross-market activities), commodities (eg, popular items and their evolution), and transactions (eg, origins and shipping destination) in anonymous marketplaces and forums, which enabled a greater understanding of the underground trading activities involved in international opioid supply and demand.

Conclusions
The results provide insight into opioid trading in the anonymous markets and forums and may prove an effective mitigation data point for illuminating the opioid supply chain.