bluuebunny/crossref_metadata_2025_split huggingface dataset:
A computational study on the complexation of Bisbenzimidazolyl derivatives with cucurbituril and cyclohexylcucurbituril
Authors: Sathiyamoorthy Venkataramanan Natarajan , A Suvitha , R. Sahara , Y Kawazoe 
Published: March 2021

Abstract
The binding properties of 1,w- bisbenzimidazolyl derivatives with cucurbit[6]uril (CB6) and cyclohexanocucurbit[6]uril (CCB6) host, for 1:1 stoichiometry, have been studied using density functional theory. The distance between the two benimidazole acidic hydrogen’s along with the flexible butyl spacer group play a vital role in the complexation with host. The energetic analysis exhibits strong complexation ability of guests with CB6 than CCB6 host. The computed enthalpy and free energy change were negative indicating the encapsulation process to be spontaneous and thermodynamically favorable and enthalpy driven. The global reactivity descriptors based charge transfer calculations show that charge transfer occurs from the guest to host molecule which was supported by the electron density difference map. The main factors for the higher stability of stable complex was the presence of C-H····O = C hydrogen bonding interactions in addition to the weak C···O, C···N, N···O, C···H, H···N type of interactions. AIM topological parameters and NCI analysis reveals the existence of weak interaction, mainly of electrostatic in nature and more number of hydrogen bonds are present in stable complexes. EDA analysis demonstrates the presence of noncovalent and electrostatic interaction with partial covalent character in the encapsulated complexes. The lower stability of CCB6 complexes compare to CB6 are due to the presence of positive Vs,max values of cyclohexanone methylene hydrogen’s on CCB6 host.
Psychosocial Quality of Life After Traumatic Brain Injury Among Children in Uganda&nbsp;
Authors: Merabu Kadondi , Lekuya Herve Monka , Henry Kiyemba , Magala John Paul , Kiryabwire Joel 
Published: March 2021

Abstract
Background: Traumatic Brain Injury (TBI) is a leading cause of sudden death and disability amongst young people. About 28% of children managed for TBI in Uganda report some degree of physical disability one-year post-injury, but little is known about their psychosocial outcomes. We aimed to elucidate the psychosocial outcomes of children with TBI, and associated factors.Methods: A cross-sectional study carried out in the Neurosurgical Unit of Mulago National Referral Hospital (MNRH), Uganda. The Pediatric Quality of Life Inventory version 4.0 parent-proxy was administered to parents/guardians of children aged 6 to 17 years who were previously managed for TBI in MNRH more than a year post-injury; their medical records were also retrieved. Linear regression was used to determine factors associated with psychosocial outcomes.Results: A total of 116 children were recruited. The overall mean psychosocial functioning was 82 ± 22.74. Using a standard deviation below the mean score as a cut-off standard,85.7% of those children had good psychosocial functioning versus 14.3% with poor functioning. A long time of more than 2 years post-TBI (adjusted β = 1.36, p=0.012) and absence of associated injuries (adjusted β= 0.30, p=0.025) were associated with good psychosocial functioning, while TBI severity was negatively associated with poor psychosocial functioning (adjusted β= -0.36, p=0.041).Conclusion: Children managed for TBI continue to have psychosocial dysfunctioning after one year following injury, although continued improvement is observed even after 2 years. The severity of TBI and the presence of associated injuries are important determinants of the psychosocial quality of life of children. Multi-disciplinary supportive care should be very effective during the first 2 years following the injury to improve the quality of life of children with TBI.
WRELM based CO-OFDM system with improved performance, spectral efficiency and computational complexity
Authors: Kaur Gurpreet , Kaur Gurmeet 
Published: March 2021

Abstract
Coherent Optical Orthogonal Frequency Division Multiplexing (CO-OFDM) system with Pilot-free phase noise compensator was introduced in order to accomplish the need of high spectral efficiency in the optical communication. In CO-OFDM system Discrete wavelet packet transforms (DWPTs) in place of Fast Fourier Transforms (FFTs) had attracted more attention since it has removed the need of cyclic prefix used to compensate fiber dispersion. In this paper, a DWPT based CO-OFDM system with Wilcoxon Robust Extreme Learning Machine based pilot-free phase noise compensator using multi-level QPSK partitioning of 16-QAM has been proposed. From the results of this work it has been seen that the percentage improvement in performance (in terms of Q-Factor) and spectral efficiency over traditional pilot-aided techniques is approximately 6 and 21 respectively. Moreover, this proposed work will comparatively reduce the overall system complexity.
Targeting Cbx3/HP1γ Induces LEF-1 and IL-21R to Promote Tumor-Infiltrating CD8 T-Cell Persistence
Authors: Thai To-Ha , Le Phuong , Ha Ngoc , Tran Ngan , Newman Andrew , Esselen Katharine , Dalrymple John , Schmelz Eva , Bhandoola Avinash , Xue Hai-Hui , Singh Prim 
Published: March 2021

Abstract
Checkpoint blockade can reverse CD8+ T-cell functional exhaustion, and TCF-1 is essential for this process. However, identifying mechanisms that can prevent functional senescence and potentiate CD8+ T-cell persistence in checkpoint blockade non-responsive tumors remains a challenge. We demonstrate that targeting Cbx3/HP1γ causes augmented transcription initiation, chromatin remodeling at Lef1 and Il21r leading to increased transcriptional activity at these loci. Mechanistic studies show LEF-1 and IL-21R are required for Cbx3/HP1γ-deficient CD8+ effector T cells to persist resulting in improved control of ovarian cancer, melanoma and neuroblastoma in pre-clinical models. Cbx3/HP1γ-deficient CD8+ T cells enhanced persistence in the TME facilitates remodeling of the chemokine/receptor landscape that ensures their optimal tumor invasion at the expense of CD4+ Tregs. Thus, CD8+ T cells heightened effector function consequent to Cbx3/HP1γ deficiency may be distinct from functional reactivation by checkpoint blockade, implicating Cbx3/HP1γ as a viable cancer T-cell-based therapy target for resistant, non-responsive solid tumors.
Monitoring and Stability Evaluation of the Damaged Landslide Based on Multiple Monitoring Technologies
Authors: Huang Wei , Zhou Chang , Xu Hong , Chen Lichuan , Liao Yunping , Liu Pengfei , Gao Yaohui 
Published: March 2021

Abstract
The stability evaluation of the damaged landslide is important for rescue work and emergency operation. This paper investigated a predisposing geological emergence, inducing the factors and deformation processes of the Zhongbao landslide, which happened on 25 July 2020. The stability of the damaged landslide was evaluated by an integrated monitoring system consisting of ground-based radar, unmanned aerial vehicles, airborne Lidar, thermal infrared temperature monitoring, GNSS displacement monitoring, deep displacement monitoring and rainfall monitoring. The strata and weak layer controlled the landslide failure, and topography defined the boundary of the failed rock mass. A continually intensive rainfall caused the deformation and accelerated failure of the landslide. The shallow and steep deposit (Part I) firstly slid at a high velocity, and then pushed the rear part of the landslide (Part II) to deform, forming numerous cracks, and the rainfall infiltrated into the rock mass. Finally, the rock and soil mass sliding along the weak layer, a barrier dam and a barrier lake were formed. The monitoring results showed that after the landslide failure, there were still local collapse and deformation occurrence which threatened rescue work and barrier lake excavation. Therefore, the barrier dam wasn’t excavated until the accumulation rate gradually stabilized on July 28. Moreover, most of the reactivated deposits still accumulated in the transportation and source areas. Thus, in August, the displacement of the damaged landslide gradually accelerated in a stepwise manner, and responded strongly to rainfall, especially in the accumulation area, so that it was inferred that the damaged landslide could slide again and caused a more threatening and severe failure. The analysis results of the study area can provide references for the failure mechanism of a rainfall-induced landslide and the stability evaluation of a damaged landslide.
AHP and GIS-based Delineation of Groundwater Potential of Papumpare District of Arunachal Pradesh (India)
Authors: Mahato Ranji , Bushi Dhoni , Nimasow Gibji , Nimasow Oyi Dai , Joshi Ramesh Chandra 
Published: March 2021

Abstract
Water is crucial to human survival. Studies on surface water are well documented but precise knowledge of groundwater resources is difficult. Thus, accurate knowledge of groundwater resources could meet the necessities of water at present and in the long run. The application of the Analytic Hierarchy Process (AHP) and Geographical Information System (GIS) together with multi-criteria parameters has emerged as an efficient technique for delineation of groundwater potential in recent decades. However, no efforts to delineate the groundwater potential have been attempted in the study area to date. Hence, in this study, the groundwater potential of Papumpare district of Arunachal Pradesh was delineated by combining AHP, GIS, and ten thematic layers (geomorphology, geology, slope, lineament density, drainage density, rainfall, distance from the major river, topographic wetness index, soil texture, and land use/land cover). The results show about 64% of the area under poor groundwater potential. Moderate and good groundwater potential is found in 31% and 5% of the area, respectively. Map-removal and single-parameter sensitivity analyses revealed that the groundwater potential map is most sensitive to the annual average rainfall with a mean variation index of 1.05% and a weight of 19.07%. The flood/alluvial plains, Siwalik formations with sediments, and level to gentle slopes receiving high rainfall show good potential, and the dissected hills/valleys, metamorphic rock assemblages, steep slopes with low rainfall reveals poor groundwater potential. The overall accuracy of 81.25% with a Kappa coefficient of 0.72 explains good agreement between the reference data and the map. The estimated area under good groundwater potential appears too little concerning the increasing population and urbanization. Therefore, the state government in general and the water resources and planning department in particular need to formulate suitable strategies to combat the water scarcity scenario waiting ahead. The study suggests raising the use of surface water from nearby rivers to lessen the pressure on groundwater resources.
A scoping review of registry captured indicators for evaluating quality of critical care in ICU.
Authors: Jawad Issrah , Rashan Sumayyah , Sigera Chathurani , Salluh Jorge , Dondorp Arjen M , Haniffa Rashan , Beane Abi 
Published: March 2021

Abstract
Background Excess morbidity and mortality following critical illness is increasingly attributed to potentially avoidable complications occurring as a result of complex ICU management [1–3]. Routine measurement of quality indicators through an EHR or registries are increasingly used to benchmark care and evaluate improvement interventions. However, existing Indicators of quality for intensive care are derived almost exclusively from relatively narrow subsets of ICU patients from high-income healthcare systems. The aim of this scoping review is to systematically review the literature on quality indicators (QIs) for evaluating critical care, identify QIs, map their definitions, evidence base, and describe the variances in measurement, and the reported challenges of implementation.Method We searched MEDLINE, EMBASE, CINAHL and the Cochrane libraries from the earliest available date through to January 2019. To increase sensitivity of the search, grey literature and reference lists were reviewed. Minimum inclusion criteria were a description of one or more QIs designed to evaluate care for patients in ICU captured through a registry platform- or Electronic Health Record (EHR) adapted for quality of care surveillance.Results The search identified 4780 citations. Review of abstracts led to retrieval of 276 full-text articles, of which 123 articles were accepted. 51 unique QIs in ICU were classified using the three components of health care quality proposed by the High Quality Health Systems (HQSS) framework. Adverse events including hospital acquired infections (13.7%) hospital processes (54.9%) and outcomes (31.4%) were the most common QIs identified. Patient reported outcome QIs accounted for less than 6%. Barriers to the implementation of QIs were described in 35.7% of articles and divided into operational barriers (51%) and acceptability barriers (49%).Conclusions Despite the complexity and risk associated with ICU care, there are only a small number of operational indicators used. Future selection of QIs would benefit from a stakeholder driven approach, whereby the values of patients and communities and the priorities for actionable improvement as perceived by healthcare providers are prioritised and include greater focus on measuring discriminable processes of care.
Molecular profiling of Neprilysin expression and its interactions with SARS-CoV-2 spike proteins to develop evidence base pharmacological approaches for therapeutic intervention
Authors: Kumar Arun 
Published: March 2021

Abstract
Neprilysin due to its peptidase activity is involved in several physiological and pathological processes. Recently our group has reported the association of neprilysin with angiotensin-converting enzyme 2 (ACE2) network proteins which facilitate the entry of SARS-COV2 virus. The potential role of neprilysin beyond its peptidase activity is not known. Using the established sequence analysis and molecular docking tools, this study evaluated the molecular profile of neprilysin interaction with SARS-COV2 virus proteins. Human neprilysin protein showed a significant sequence similarity with SARS-COV2 spike protein, which was further confirmed by observation of considerable interaction in the molecular docking. Human neprilysin protein was also found to additionally interact with SARS-COV2 proteins facilitating virus replication. The potential of neprilysin inhibitors (Sacubitril and Sacubitrilat) to interfere with neprilysin and SARS-COV2 proteins interactions was assessed. The neprilysin inhibitors showed binding efficacy within therapeutically feasible concentration range (1 to 150 uM). This study while reporting a novel role of neprilysin as potential receptor for SARS-COV2 virus, highlights the merit in assessing clinical efficacy of neprilysin inhibitors for the management of SARS-COV2 infection.
Investigating opportunities for use of alternative coagulants for drinking water treatment at Morton Jaffray Water Treatment works, Harare, Zimbabwe
Authors: Hoko Zvikomborero , Manganye Lawrence , Chipfunde Lisben 
Published: March 2021

Abstract
Drinking water treatment at Harare's main water works, Morton Jaffray Water Treatment Works (MJWTW), has been a challenge due to source (Lake Chivero) pollution, and the efficacy of some of the processes and chemicals including aluminium sulphate (alum) has been questioned. This study investigated the use of an alternative coagulant to the traditional use of alum at MJWTW. The effectiveness of five coagulants, namely Anhydrous Poly Aluminium Chloride (APAC), Poly Aluminium Chloride (PAC), Primco 100, Zetafloc 4030 and alum (control) was investigated by flocculation tests in a laboratory using Lake Chivero water. Parameters analysed included pH, turbidity, Electrical Conductivity (EC) and chlorophyll-a for raw water and treated water. Raw water mean pH was 7 ± 0.4, turbidity (3.3 ± 0.2 NTU), EC (337 ± 5.0 μS/cm) and chlorophyll-a concentration (2.28 μg/L). Primco 100 had the best performance with the lowest optimum dosage of 25 mg/L while alum had the highest dosage of 55 mg/L. APAC, PAC, Primco 100 and Zetafloc 4030 did not change the pH of water significantly but alum did. The study concluded that Primco 100 was the most suitable coagulant and could be an alternative to alum.
Nanofiltration membranes for salt and dye filtration: effect of membrane properties on performances
Authors: Ağtaş Meltem , Ormancı-Acar Türkan , Keskin Başak , Türken Türker , Koyuncu İsmail 
Published: March 2021

Abstract
In this study, commercial nanofiltration membranes (Toray, NF 270, Desal 5 L) were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, optical profilometry, contact angle, mechanical strength and zeta potential measurements. Filtration performance tests were conducted with distilled water, MgSO4 solution and synthetic dye solutions, respectively. Among three commercial membranes, the Toray membrane was thought to be better choice. Additional experiments were carried out for a more detailed characterization of the selected membrane. Therefore, firstly, flux and removal efficiency was monitored by using dye solutions at different pH values, and then experiments were carried out to observe the effect of different temperatures. Also, another filtration test with NaCl solution was performed for the Toray membrane. As the main purpose of this study, we aimed to establish a significant correlation between the structural properties of membranes and their performances. In light of the results obtained, it was observed that the contact angle, mechanical strength and surface roughness values of the membrane significantly affected the membrane performance. It was concluded that the most important parameter in dye removal was the zeta potential. As a result of this work, a data set of commercial membranes was created and is available to all membrane users.
Pengembangan multimedia interaktif tema binatang untuk pembelajaran di taman kanak-kanak
Authors: Kartini Kartini , Degeng I Nyoman Sudana , Sitompul Nurmida Catherine 
Published: March 2021

Tujuan dari penelitian ini yakni untuk menghasilkan produk media pembelajaran interaktif yang layak digunakan untuk mengenalkan berbagai macam binatang pada materi tema binatang pada anak taman kanak-kanak kelompok A. Untuk melihat kelayakan dari penelitian ini ditinjau dari tiga aspek antara lain: aspek edukatif, estetika, dan teknis. Model pengembangan yang digunakan dalam penelitian ini mengadaptasi dan memodifikasi langkah-langkah penelitian dan pengembangan Brog & Gall. Dalam penelitian ini pengumpulan data menggunakan observasi, wawancara, angket atau kuesioner, dan dokumentasi. Analisis data diolah menggunakan deskriptif kuantitatif. Hasil validasi dari ahli materi memperoleh penilaian rata-rata skor 4,25 dengan kriteria sangat baik, adapun penilaian dari ahli media memperoleh rata-rata skor 4,42 dengan kriteria sangat baik. Penilaian dari guru kelompok A memperoleh nilai 100%, sedangkan uji coba lapangan awal dengan kelompok kecil memperoleh penilaian sebesar 97,22% dengan kriteria layak, hasil uji coba lapangan dengan kelompok besar memperoleh penilaian sebesar 92,15% dengan kriteria layak. Dapat disimpulkan bahwa secara keseluruhan media pembelajaran interaktif “Dunia Binatang” layak digunakan sebagai media pembelajaran interaktif untuk mengenalkan berbagai macam binatang pada anak taman kanak-kanak.AbstractThis study aims to produce interactive learning media products that are feasible to use to introduce various animals in animal theme material in group A kindergarten children. To see this research's feasibility in three aspects, including educational, aesthetic, and technical aspects. The development model used in this study adapted and modified the steps of the research and development of Brog and Gall. In this study, data collection using observation, interviews, questionnaires or questionnaires, and documentation. Data analysis was processed using quantitative descriptive. The material experts' validation obtained an average rating of 4.25 with perfect criteria, while the assessment of the media experts obtained an average score of 4.42 with excellent standards. The evaluation of the group A teacher scored 100%. In comparison, the initial field trials with the small group received an estimate of 97.22% with the eligibility criteria. The field trials results with the large group received an assessment of 92.15% with the eligibility criteria. So it can be concluded that overall the interactive learning media "Animal World" is suitable to be used as an interactive learning media to introduce various animals to kindergartens.
Pengembangan multimedia pembelajaran matematika sebagai upaya mendukung proses pembelajaran blended learning
Authors: Swara Ganda Yoga , Ambiyar Ambiyar , Fadhilah Fadhilah , Syahril Syahril 
Published: March 2021

Penelitian ini bertujuan untuk menghasilkan produk multimedia pembelajaran matematika untuk siswa Sekolah Dasar (SD) dan melihat sejauh mana produk multimedia tersebut dapat dimanfaatkan siswa dalam upaya mendukung proses blended learning. Penelitian ini dilaksanakan di SD Negeri 07 Kota Padang dengan menggunakan metode Waterfall Model. Waterfall Model atau sering kali disebut sebagai classic life cycle adalah model pengembangan perangkat lunak yang menekankan fase-fase yang berurutan dan sistematis, dimulai dari analisis kebutuhan konsumen dan berkembang melalui proses perencanaan (planning), implementasi (implementation), pengujian (Testing), dan pemeliharaan (maintenance), yang berujung pada dukungan terus menerus untuk sebuah perangkat lunak yang utuh. Hasil penelitian menunjukkan bahwa produk multimedia yang dihasilkan adalah multimedia pembelajaran matematika untuk siswa SD. Dapat disimpulkan bahwa aplikasi ini dapat menciptakan proses pembelajaran online yang efektif dan terintegrasi antara guru dengan siswa. Mempermudah siswa-siswi sekolah dasar dalam belajar matematika dimanapun dan kapanpun. Produk multimedia yang dihasilkan layak sebagai media pembelajaran berdasarkan hasil validasi oleh guru dan siswa, dengan hasil penilaian sangat baik (4,4). AbstractThis study aims to produce multimedia learning mathematics products for elementary school (SD) students and see the extent to which these multimedia products can be used by students in an effort to support the blended learning process. This research was conducted at SD Negeri 07 Padang City using the Waterfall Model method. Waterfall Model or often referred to as the classic life cycle is a software development model that emphasizes sequential and systematic phases, starting from the specification of consumer needs and developing through the planning, modeling, construction, and development processes. deployment, which results in ongoing support for a complete piece of software. The results showed that the multimedia product produced was multimedia learning mathematics for elementary students. It can be concluded that this application can create an effective and integrated online learning process between teachers and students. Make it easier for elementary school students to learn mathematics anywhere and anytime. The resulting multimedia products are feasible as learning media based on the results of validation by teachers and students, with excellent assessment results (4,4).