bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Gut Microbiota Metabolite Urolithin B Improves Cognitive Deficits by Inhibiting Cyt C-Mediated Apoptosis and Promoting the Survival of Neurons Through the PI3K Pathway in Aging Mice
Authors: Chen Peng , Chen Fuchao , Lei Jiexin , Wang Gaohua , Zhou Benhong 
Published: November 2021

Background: Despite considerable advances in pharmacotherapy, more effective therapeutic interventions for aging-related neurodegenerative disorders (NDs), such as Alzheimer’s disease (AD), remain limited. Urolithin B (UB), one of the major subcategories of urolithins (microbiota metabolites) found in various tissues after ellagitannin consumption, has been shown to possess antioxidant, anti-inflammatory, and antiapoptotic effects. However, the neuroprotective effect of UB on brain aging in mice and its potential mechanisms were still unknown.Methods: In the current research, we first assessed the ameliorative effects of UB on oxidative injury and apoptosis induced by H2O2 in neuro-2a cells. Then a subcutaneous injection of D-galactose in mice for 8 weeks was used to establish the aging model to evaluate the protective effects of UB. The capacity of memory and learning, alterations of hippocampus histology and corresponding molecular mechanisms were all evaluated.Results: The D-gal-induced accelerated aging model in vivo demonstrated that UB could significantly ameliorate deficits in learning and memory by inhibiting the accumulation of advanced glycation end products (AGEs) and elevating the expression and activity of Cu, Zn-SOD and CAT. Furthermore, UB downregulated the c-Jun N-terminal kinase (JNK) signaling pathway and prevented cytochrome c release from isolated mitochondria, thereby inhibiting neuronal apoptosis during the aging process. More importantly, UB stimulation of aging mice activated ERK and phosphoinositide 3-kinase (PI3K), leading to neuronal survival along with Akt and p44/42 mitogen-activated protein kinase (MAPK) phosphorylation and activation.Conclusion: In summary, UB effectively alleviated cognitive deficits and ameliorated brain aging-related conditions and could be considered a healthcare product to prevent aging-associated NDs such as AD.
Comparing the Self- and External Assessment Versions of the HCL-33 as Screening Instruments for Bipolar Disorder in Older Depressed Patients
Authors: Zhang Xinqiao , Li Wen , Zhao Na , Jin Yu , Cheung Teris , Ungvari Gabor S. , Cui Xi-Ling , Wang Gang , Xiang Yu-Tao , Angst Jules 
Published: November 2021

Objectives: The misdiagnosis of bipolar disorder (BD) as major depressive disorder (MDD) is common in depressed older adults. The self-rated HCL-33 and its external assessment version (HCL-33-EA) have been developed to screen for hypomanic symptoms. This study compared the screening ability of these two instruments to discriminate BD from MDD.Methods: A total of 215 patients (107 with BD and 108 with MDD) and their carers were recruited. Patients and their carers completed the HCL-33 and HCL-33-EA, respectively. The consistency of the total score and the positive response to each item between the two scales was calculated with the intraclass correlation coefficient (ICC) and Cohen's kappa coefficient separately. Receiver operating characteristics (ROC) curves were drawn for both instruments. The optimal cut-off points were determined according to the maximum Youden's Index. The areas under the ROC curve (AUC) of the HCL-33 and HCL-33-EA were calculated separately and compared. The sensitivity and specificity at the optimal cut-off values were also calculated separately for the HCL-33 and HCL-33-EA.Results: The intraclass correlation coefficient (ICC) between the total scores of the HCL-33 and HCL-33-EA was 0.823 (95% CI = 0.774–0.862). The positive response rate on all items showed high agreement between the two instruments. ROC curve analysis demonstrated that the total scores of both HCL-33 and HCL-33-EA differentiated well between MDD and BD, while there was no significant difference in the AUCs between the two scales (Z = 0.422, P = 0.673). The optimal cutoff values for the HCL-33 and HCL-33-EA were 14 and 12, respectively. With the optimal cutoff value, the sensitivities of the HCL-33 and HCL-33-EA were 88.8% and 93.5%, and their specificities were 82.4% and 79.6%.Conclusion: Both the HCL-33 and HCL-33-EA had good screening ability for discriminating BD from MDD in depressed older adults.
Outcomes of Ventriculoperitoneal Shunt in Patients With Idiopathic Normal-Pressure Hydrocephalus 2 Years After Surgery
Authors: Popal Abdul Malik , Zhu Zhoule , Guo Xinxia , Zheng Zhe , Cai Chengwei , Jiang Hongjie , Zhang Jianmin , Shao Anwen , Zhu Junming 
Published: November 2021

Objective: To evaluate the outcomes and prognostic factors of ventriculoperitoneal shunts (VP-shunts) in patients with idiopathic normal-pressure hydrocephalus (iNPH) at 6 months and 2 years after surgery.Method: We retrospectively analyzed 68 patients admitted to our institute and diagnosed with probable iNPH from January 2017 to March 2021. All patients underwent VP-shunt surgery with a programmable valve, and their outcomes were assessed via the Krauss index and modified Rankin scale (mRS) at 6 months and 2 years post-surgery. Univariate and multivariate regression analysis was performed to identify the prognostic factors.Results: The mean age of the patients was 71.1 ± 8.4 (mean ± standard deviation) years. On the Krauss improvement index, 6-month follow-up results were available for 68 patients. Of these patients, 91.2% experienced attenuation of their preoperative symptoms, with a mean Krauss index of 0.58 ± 0.27, and 48 patients (70.6%) had a Krauss index ≥0.5. Two-year follow-up results were available for 33 patients; 90.9% of them had sustained improvement, with a Krauss index of 0.54 ± 0.31, and 21 patients (66.3%) had a Krauss index ≥0.5. Thirty-three patients (58%) were living independently after 2 years (mRS 0–2). The outcomes were worse for patients with multiple comorbidities. Neither an increased patient age nor a prolonged history of illness was statistically significant prognostic factors for adverse outcomes of VP-shunt surgery.Conclusion: Surgical treatment was well-tolerated by patients with iNPH who received VP-shunts. Most patients experienced attenuation of their preoperative symptoms. Multiple concurrent comorbidities should be considered as adverse prognostic factors before shunt insertion in patients with iNPH.
Dynamic development of the winery sector in Greece
Authors: Пасхалидис Х.Д. , Папаконстантину Л.Д. , Сотиропулос С.С. , Петропулос Д.П. , Таскос Д.Г. , Пасхалидис Д.Х. , Чамурлиев Г.О. 
Published: November 2021

Виноградарство в Греции - старейшая отрасль, но в последние годы наблюдается сокращение площадей, предназначенных для производства винодельческой продукции. Производство и маркетинг вина - сильная промышленность в мировой экономике. Международный и внутренний рынки стандартизированных вин считаются высоко конкурентными и комплексными. История греческого вина охватывает чрезвычайно долгий период, самый продолжительный в мире с точки зрения непрерывного выращивания винограда и производства вин с незапамятных времен. Виноделие - один из важнейших секторов греческой экономики не только для внутреннего рынка напитков, но и для развития и продвижения традиционных греческих продуктов за рубежом в целом. В винодельческой отрасли в последние годы произошли структурные изменения, направленные на повышение конкурентоспособности греческих вин для занятия ими достойного места на международном рынке. В последние пять лет среди греческих винных компаний стали появляться тенденции к международной экстраверсии. Греция по производству вина занимает 12-е место в мире и 4-е в Европейском Союзе. В этой работе делается попытка составить карту «маршрута» вина с его разновидностями и объемами производства по всей Греции.
Viticulture in Greece is the oldest, but in recent years there has been a reduction of areas intended for wine production. Wine production and marketing is a strong industry worldwide. The global and domestic market for standardized wine is considered to be complex and highly competitive. The history of Greek wine covers an extremely long period of time, the longest in the world, in terms of continuous cultivation of the vine and the timeless production of wines. The wine industry is one of the most important sectors of Greek economy not only for the domestic beverage market, but also for the development and promotion of Greek traditional products in general in foreign markets. In wine industry, structural changes have taken place in recent years aimed to increase the competitiveness of Greek wines, in order to gain a worthy position in the international market. Last five years, there has been a trend for international extroversion by Greek wine companies. Greece with wine production occupies 12 place in the world and 4 in the European Union. This work attempts to map the "route" of wine with its varieties and production quantities throughout Greece.
Original research Factors of effective adaptation of grape plants to conditions
Authors: Павлова И.А. , Гавриленко И.В. , Матяш Ю.С. , Гавриленко А.В. , Шанин Д.А. , Лиховской В.В. , Гончаренко В.А. 
Published: November 2021

Одним из самых важные этапов технологии, от которого напрямую зависит эффективность процесса размножения, является адаптация растений in vitro к условиям ex vitro . Основная задача адаптации состоит в смягчении стрессовой нагрузки и обеспечении плавного перехода к культивированию в новых условиях. Цель исследования - определение факторов, обеспечивающих эффективную адаптацию растений винограда in vitro к условиям ex vitro на примере сорта-подвоя Кобер 5 ББ (Берландиери x Рипариа Кобер 5ББ). Использование для подсвета лампы белого дневного света и фитолампы являлось положительным фактором для ускорения процессов адаптации к условиям ex vitro , способствовало нормализации фотосинтеза, стимулированию морфогенеза и высокому уровню приживаемости. Применение субстрата на основе 100 % торфа верхового с показателями кислотности рН 5,6-6,5 позволило достичь 100 % приживаемости на этапе адаптации без дополнительной подкормки. На стадии доращивания адаптированных растений также целесообразно использование торфа в качестве субстрата, благодаря его антисептическим и бактерицидным свойствам, но уже с обязательными подкормками. В целом проведение адаптации в конце лета с последующей высадкой на доращивание в начале осени имеет положительную тенденцию.
One of the most important technology stages, on which the efficiency of propagation process directly depends, is the adaptation of plants in vitro to ex vitro conditions. The main task of adaptation is to mitigate stress loading and ensure smooth transition to cultivation in new conditions. The aim of the study is to determine the factors, ensuring effective adaptation of grape plants in vitro to ex vitro conditions using the example of the rootstock variety ‘Kober 5 BB’ (‘Berlandieri x Riparia Kober 5BB’). Using of white daylight lamp and phytolamp for additional illumination is a positive factor for accelerating adaptation processes to ex vitro conditions, contributed to normalization of photosynthesis, stimulation of morphogenesis and high survival ability. Using of a substrate based on 100% high-moor peat with acidity of pH 5.6-6.5 made it possible to achieve 100% survival rate at the stage of adaptation without additional nutrition. At the stage of completing growing of adapted plants, it is also advisable to use peat as a substrate due to its antiseptic and bactericidal properties, but with obligatory extra-nutrition. In general, adaptation in late summer followed by planting to complete growing in early autumn has a positive development.
Inovasi Pembuatan Teh Herbal dari Jantung Pisang dengan Tambahan Daun Stevia Sebagai Pemanis Alami
Authors: Sinulingga Siska Esperanza , Sebayang Loraetta Brety , Sihotang Samuel 
Published: November 2021

(Article History: Received August 27, 2021; Revised Sept 17, 2021; Accepted Sept 26, 2021) ABSTRAKInovasi bahan dasar yang dapat dijadikan teh herbal adalah jantung pisang, karena memiliki metabolit sekunder berupa flavonoid, kumarin dan golongan fenolik. Penelitian ini bertujuan untuk membuat teh herbal jantung pisang dan mengetahui standar mutunya. Pembuatan teh herbal dilakukan dengan variasi suhu pengeringan 50°C; 90°C; 110°C dan waktu pengeringan 110; 130; 150 menit kemudian dilakukan uji standar mutu dan skrining serbuk teh herbal. Hasil uji persyaratan mutu teh herbal: kadar air (7,1%; 6,8%; 2,3%), kadar ekstrak dalam air (5,96%; 8,6%; 5 0,76%), kadar abu total (7,4%; 6,2%; 3,9%), kadar abu larut air (4,62%; 7,88%; 10,09%), kadar abu tidak larut asam (0,93%; 0,7%; 0,47%), kandungan flavonoid total 0,0002543 mg QE/g ekstrak dan cemaran mikroba 3,3×104 koloni/ml. Pembuatan teh jantung pisang dengan tambahan pemanis alami stevia memenuhi standar mutu produk teh herbal.Kata kunci: Teh herbal; jantung pisang; daun stevia; variasi suhu ABSTRACTBasic ingredient innovation that can be used as herbal tea is banana blossom, because of its secondary metabolites such flavonoids, coumarins and phenolic groups. This study aims to make banana blossom herbal tea and determine the quality standard. Formulation of herbal tea by varying drying temperature of 50°C; 90°C; 110°C and drying time 110; 130; 150 minutes, the quality standard test and herbal tea powder screening were carried out. Results of herbal tea quality: water content (7.1%; 6.8%; 2.3%), extract content in water (5.96%; 8.6%; 5 0.76%), ash content total (7.4%; 6.2%; 3.9%) water soluble ash content (4.62%; 7.88%; 10.09%) acid insoluble ash content (0.93%; 0, 7%, 0.47%, total flavonoid content 0.0002543mg QE/g extract, microbial contamination 3.3×104 colonies/ml. Formulation of banana blossom tea with the addition of natural sweetener stevia meets the quality standards of herbal tea products,Keywords: Herbal tea; banana blossom; stevia leaf; temperature variation
Effect of annealing time and pressure on electrical activation and surface morphology of Mg-implanted GaN annealed at 1300 °C in ultra-high-pressure nitrogen ambient
Authors: Sumida Kensuke , Hirukawa Kazufumi , Sakurai Hideki , Sierakowski Kacper , Horita Masahiro , Bockowski Michal , Kachi Tetsu , Suda Jun 
Published: November 2021

Abstract
We performed an isothermal annealing study on Mg-implanted GaN at 1300 °C in an ultra-high-pressure (1 GPa) nitrogen ambient. Annealing for more than 30 min resulted in a high acceptor activation ratio and a low compensation ratio that were comparable to those obtained with annealing at 1400 °C for 5 min. We also performed annealing at 1300 °C in a reduced nitrogen pressure of 300 MPa which makes us possible to expand the inner diameter of annealing equipment in the future. High electrical activation, similar to one obtained by annealing at 1 GPa, was successfully obtained.
Low-frequency multiplex CARS microscopy with a high-repetition near-infrared supercontinuum laser
Authors: Arashida Yusuke , Taninaka Atsushi , Ochiai Takahiro , Mogi Hiroyuki , Yoshida Shoji , Yoshimura Masamichi , Takeuchi Osamu , Shigekawa Hidemi 
Published: November 2021

Abstract
We have developed a multiplex coherent anti-Stokes Raman scattering microscope effective for low-wavenumber measurement by combining a high-repetition supercontinuum light source of 1064 nm and a near-infrared high-sensitivity InGaAs diode array. This system could observe the low-wavenumber region down to 55 cm−1 with high sensitivity. In addition, using spectrum shaping and spectrum modulation techniques, we simultaneously realized a wide bandwidth (<1800 cm−1), high wavenumber resolution (9 cm−1), high efficiency, and increasing signal-to-noise ratio by reducing the effect of the background shape in the low-wavenumber region. Spatial variation of a sulfur crystal phase transition with metastable states was visualized.
MODEL ELECTRONIC WORD OF MOUTH DAN RATING DALAM MEMPENGARUHI MINAT BELI PADA MARKETPLACE SHOPEE PADA MASA PANDEMI COVID-19
Authors: Citra Savitri  , Robby Fauji  
Published: November 2021

Tujuan penelitian ini adalah untuk menganalisis bagaimana pengaruh Electronic Word Of Mouth dan Rating terhadap Minat Beli pada Marketplace Shoppee pada Masa Pandemi Covid-19. Kemajuan teknologi informasi dan perubahan perilaku konsumen dalam memilih, menentukan dan menggunakan produk dan jasa menjadi salah satu alasan perusahaan untuk terus berkembang. Ketergantungan pada penggunaan internet dan perkembangan bisnis e-commerce di Indonesia terutama pada produk fesyen menjadi peluang untuk terus meningkatkan strategi bisnis yang dimiliki khususnya pada Marketplace Shoppee. Intensitas konsumen dalam penggunaan internet menjadi peluang bagi pebisnis digital untuk terus meningkatkan startegi dalam memasarkan produk dan jasa yang dimiliki.
Penelitian ini menggunakan metode analisis deskriptif verifikatif dengan analisis data menggunakan Path Analysis dengan teknik pengumpulan data menggunakan data melalui angket dan wawancara yang disebar kepada 189 responden. Hasil dari penelitian ini membuktikan bahwa e-wom, rating dan minat beli memiliki kriteria baik berdasarkan rentang skala. Sedangkan analisis verifikatif menyatakan bahwa e-wom memiliki pengaruh secara parsial terhadap minat beli tetapi tidak signifikan sedangkan rating memiliki pengaruh signifikan secara parsial terhadap minat beli. Sedangkan pengaruh simultan antara e-wom dan rating terhadap minat beli signifikan. Penelitian ini dapat memberikan kontribusi bagi marketplace yang ada di Indonesia untuk mengembangkan pola startegi pemasaran digital yang sesuai dengan kebutuhan dan keinginan konsumen.
KATA KUNCI: e-wom, rating,minat beli, Market Place.
BAGAIMANA RISIKO KREDIT PADA MASA AWAL PANDEMIC?
Authors: Rengga Madya Pranata  , Nugraha  , Ikaputera Waspada  
Published: November 2021

Tujuan penelitian ini bertujuan untuk melihat atau menganalisis risiko bank yang mengikuti POJK dalam hal profitabilitas dan pertumbuhan kredit yang terjadi pada saat masa awal Covid - 19. Metode penelitian yang digunakan adalah deskriptif dan verifikatif dengan desain explanatory . Populasi penelitian adalah seluruh bank peserta program POJK di Indonesia. Pengumpulan data diperoleh dari website ojk.go.id untuk dianalisis. Analisis data dilakukan dengan analisis regresi berganda. Hasilnya menunjukan bahwa risiko kredit pada masa pendemik secara Bersama sama dipengaruhi oleh pertumbuhan kredit dan profitabilitas, akan tetapi hanya profitabilitas yang mempengaruhi risiko kredit secara parsial, yang menunjukan meningkatnya profitabilitas akan menurunkan risiko kredit pada masa panedemic ini.
Kata kunci : Risiko kredit, Profitabilitas, Pertumbuhan kredit, Covid 19.
PERAN PENDIDIKAN KEWARGANEGARAN SEBAGAI UPAYA MEMBANGUN MORAL PESERTA DIDIK DALAM MENANGGAPI BERITA HOAX
Authors: Yudi Firmansyah  , Nufikha Ulfah  , Prihma Sinta Utami  
Published: November 2021

Kerusuhan merupakan suatu tindak kejahatan, dimana sekelompok orang berkumpul bersama dengan tujuan melakukan tindak kekerasan. Kerusuhan ini terjadi karena maraknya berita bohong/hoax yang beredar dikalangan masyarakat, sehingga hal ini membuat suatu keresahan. Melihat fenomena ini menggambarkan terjadinya penurunan moral pada generasi bangsa. Hal ini dikarenakan sebagian besar pengguna media sosial adalah mereka yang masih duduk dibangku sekolah, kurangnya ilmu dalam menyaring setiap informasi yang ada membuat mereka menjadi mudah terprovokasi. Maka disinilah pentingnya peran pendidikan kewarganegaraan sebagai pendidikan moral dan karakter dalam membangun kecerdasan moral bangsa. Dengan membangun kecerdasan moral diharapkan dapat memperbaiki karakter penerus bangsa karena pendidikan kewarganegaraan merupakan salah satu upaya dalam membekali peserta didik sebagai generasi muda dalam memutuskan rantai penyebaran hoax, karena masa depan negara ini tergantung dari kualitas para penerus bangsanya. Pendidikan Kewarganegaraan sebagai wahana Pendidikan Moral diharapkan dapat memberikan kontribusi kepada peserta didik dalam memahami pentingnya nilai-nilai moral dan dijadikan sebagai pedoman dalam bertingkah laku khususnya dalam menanggapi berita hoax.

Riot is a crime, where a group of people gather together with the aim of committing acts of violence. This riot occurred due to the rampant hoaxes / hoaxes circulating among the public, so that this created anxiousness. Seeing this phenomenon illustrates the occurrence of moral decline in the nation's generation. This is because most social media users are those who are still in school, the lack of knowledge in filtering every available information makes them easily provoked. So this is where the important role of education in instilling character education, to build the nation's moral intelligence. By building moral intelligence, it is hoped that it can improve the character of the nation's successor because education is the right place to break the chain of hoaxes, the future of this country depends on the quality of the nation's successors. So it is hoped that it can make students understand the importance of moral values, so that they can be used as guidelines in behavior, and behave as humans, and have the ability to understand the differences between right and wrong so that they are more careful in taking actions, such as thinking before taking action. And moral education is expected not only in theory, but the need for direct practice, so that students can get used to how to behave properly and correctly.
Kata kunci: Berita Hoax, peran PKn, moral
Risk of Cancer Among Sarcoidosis Patients With Biopsy-verified Nonnecrotizing Granulomatous Inflammation: Population-based Cohort Study
Authors: Faurschou Mikkel , Omland Lars H. , Obel Niels , Lindhardsen Jesper , Baslund Bo 
Published: November 2021

ObjectiveTo assess the long-term risk of hematologic cancers, invasive solid tumors, and nonmelanoma skin cancer (NMSC) among sarcoidosis patients with biopsy-verified nonnecrotizing granulomatous inflammation.MethodsWe used Danish administrative registers with nationwide coverage to construct a cohort of 3892 patients with sarcoidosis and an age- and sex-matched comparison cohort of 38,920 population controls. For all patients, a biopsy demonstrating nonnecrotizing granulomatous inflammation had been obtained from the lower respiratory tract at the time of diagnosis. Study outcome was time to diagnosis of cancer. Follow-up began at time of sarcoidosis diagnosis and continued for up to 10 years. We calculated hazard ratios (HRs) as estimates of the cancer risk among the patients with sarcoidosis relative to that among the population controls and used cumulative incidence functions to calculate absolute 10-year risk estimates.ResultsWe observed an increased long-term risk of hematologic cancers (HR during the first 2 years of follow-up: 2.71 [95% CI 1.18–6.25]; HR after > 2 years of follow-up: 2.12 [95% CI 1.29–3.47]) and NMSC (HR after > 2 years of follow-up: 1.82 [95% CI 1.43–2.32]) among the patients with sarcoidosis. An increased risk of invasive solid tumors was only observed during the first 2 years (HR 1.55, 95% CI 1.18–2.04). Compared with the population controls, the patients with sarcoidosis had an increased absolute 10-year risk of hematologic cancers (risk difference 0.56%, 95% CI 0.11–1.01%) and NMSC (risk difference 1.58%, 95% CI 0.70–2.47%).ConclusionSarcoidosis patients with biopsy-verified nonnecrotizing granulomatous inflammation have an increased long-term risk of hematologic cancers and NMSC compared with the general population.