bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Characteristics and Genetic Analysis of Interstitial Lung Disease in Chinese Children (Genes and Interstitial Lung Disease)
Authors: Huang Mei-Xia , Qin Lu , Zhang Fei-Zhou , Wu Lei , Yu Jia-Hui , Tang Lanfang 
Published: October 2021

Abstract
BackgroundMutation in the surfactant protein C gene (SFTPC) is a cause of interstitial lung disease (ILD). Our objective was to investigate the clinical characteristics, outcome and influencing factors of ILD in Chinese children with SFTPC mutations.MethodA total of 8 Chinese children with ILD heterozygous for SFTPC mutations that were treated in our hospital from January 2014 to December 2020 were included in our study. Candidate genes responsible for surfactant dysfunction were sequenced by next-generation sequencing. The clinical and genetic data were reviewed retrospectively.ResultsThe children’s onset age was before the age of 2 years, and one case was just after birth. The most significant clinical manifestations were cough, tachypnea, hypoxemia and failure to thrive. The most common mutation was p. lle73Thr, which accounted for 87.5% (7/8) of our patients. Four patients whose onset was within 3 months, including 3 children with CMV infection, died. Conclusionp. lle73Thr mutation of SFTPC was an important and common cause of ILD in the Chinese children. The clinical manifestations of ILD associated with this mutation are not specific. The severity and outcome of the disease may be affected by factors such as onset age and viral infection.
Describing long-term opioid use utilizing Nordic Prescription Registers – A Norwegian example
Authors: Hamina Aleksi , Hjellvik Vidar , Handal Marte , Odsbu Ingvild , Clausen Thomas , Skurtveit Svetlana 
Published: October 2021

Abstract
Previous studies have defined long-term opioid use in varying ways, decreasing comparability, reproducibility and clinical applicability of the research. Based on recent systematic reviews, we aimed to estimate long-term opioid use defined as use persisting more than three months using one of the Nordic prescription registers. We used the Norwegian Prescription Register (NorPD) to extract data on all opioid dispensations between January 1st 2004 and October 31st 2019. New users of opioids (washout 365 days) were defined as long-term users if they filled two criteria: 1) they had ≥2 dispensations of opioids, 91-180 days apart; 2) days 0-90 included ≥90 dispensed administration units (e.g., tablets) of opioids. Overall, there were 2,543,224 new users of opioids during the study period. Of these, 354,666 (13.9%) filled the criteria for long-term opioid use at least once. Compared to those who did not fill the criteria (short-term users), long-term users were older, more likely women, and used tramadol, oxycodone, and buprenorphine more frequently as their first opioid. In conclusion, we found that 1/7 of opioid users continued use longer than 3 months. Future outcome research should identify the clinically most important dose requirements for long-term opioid use criteria.
The Occupational Stress from Workplace Violence and the 2019-nCoV Pandemic in Chinese Healthcare Professionals: A Mobile App-Based Survey
Authors: Sun Chao , Zhao Lanbo , He Lisong , Ma Zhihua , Zou Junkai , Jing Wei , Li Qing , Guo Lin , Du Jiang , Li Qiling 
Published: October 2021

Abstract
Objectives: To investigate the medical occupational risk and stress level of workplace violence (WPV) and novel coronavirus 2019 ( 2019-nCoV) pandemic in Chinese healthcare professionals (HPs).Methods: A national questionnaire survey was created to investigate HPs from 21 provinces of China. Seven questions in environment part and eight questions in stress part were used to assess medical occupation risk and stress respectively. Categorical data were statistically analyzed using chi-square tests. Structural equation model was performed to examine the correlations and differences among experiences of WPV, the 2019-nCoVpandemic, and occupational stress.Results:Totally, 1241 HPs completed the online survey from March 1st, 2020 to May 25th, 2020. The majority of the participants thought the current Chinese medical occupation was in inferior circumstance (n = 433, 34.89%), at high risk (n = 1082, 81.19%) and was in middle class (n = 717, 57.78%). Work-related stress ranked first of medical occupational risk (n = 786, 63.34%). When being asked the possility for their children to choose medicine, most HPs were uncertain (n = 542, 43.67%) or opposed (n = 547, 44.08%). More HPs thought there was no stress under 2019-nCoV pandemic (n = 303, 24.42%) than that under WPV (n = 48, 3.87%). WPV (Stress index = 3.23) put more pressure on HPs than the 2019-nCoV pandemic did (Stress index = 2.33) with significant difference (P = 0.006). WPV had a positive relationship with increasing doctor-patient conflicts (E=0.5, P0.000), and a negative correlation with ego-enhancement (E=-0.2, P=0.000) and public concern (E=-0.2, P=0.000). The 2019-nCoV pandemic had a positive correlation with ego-enhancement (E=0.09, P=0.006), the public's concern (E=0.1, P=0.002) and healthcare reform (E=0.1, P=0.000).Conclusions: Most HPs believe that the current environment for Chinese medical occupation is abominable and at high risk. Compared with WPV, the 2019-nCoV pandemic increases personal risks and reduces psychological stress to HPs. WPV weakens enthusiasm and significantly intensifies doctor-patient conflicts.
Novel Metabolic Biomarker for Early Detection and Prognosis to the Patients with Gastric Cardia Adnocarcinoma
Authors: Wei Mengxia , Zhao Xueke , Wang Panpan , Song Xin , Hu Jingfeng , Zhong Kan , Lei Lingling , Xu Ruihua , Han Wenli , Yang Miaomiao , Han Xuena , Fan Zongmin , Wang Ran , Li Bei , Ji Jiajia , Li Liuyu , Chen Yao , Yang Yuanze , Zhao Keke , Zhou Fuyou , Li Aili , Li Zhiqiang , Bao Qide , Wang Li Dong 
Published: October 2021

Abstract
Background: Gastric cardia adenocarcinoma (GCA), which has been normalized as type II of adenocarcinoma at esophagogastric junction in western countries. In clinical, most of the GCA patients are lack of early alarming symptoms, more than 90% of GCA patients were diagnosed at advanced stage, resulted in a very poor prognosis, with less than 20% of 5-year survival. Obviously, early detection for GCA plays crucial role in decreasing the high mortality. Metabolomics allows for appraisal of small molecular mass compounds in a biofluid, which may provide a way for finding biomarkers for GCA. Methods: The serum metabolic features of 276 curatively resected GCA patients and 588 healthy control participates were collected from the database of State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital of Zhengzhou University to discover the metabolic dysregulation by using the ultraperformance liquid chromatography-mass spectrometry (UPLC-MS). Joint pathway analysis with metabolites identified, survival analysis and auxiliary diagnosis metabolites were discussed in present work. Results: A sum of 200 known differential metabolites were obtained with p＜0.05 and fold change FC≥1.25 or FC≤0.8 by comparison GCA and healthy control participates. 12 metabolites significant correlated with survival (p＜0.05) and 17 metabolites for potential auxiliary diagnosis(FC＞1.5 or FC＜0.67) for GCA. Dysregulated arginine biosynthesis was an important pathway of GCA. 9 differential metabolites of 12-ketolithocholic acid, 2-Hydroxybutanoic acid, Aldosterone, All-trans-13,14-dihydroretinol, Hododeoxycholic acid, L-histidine, Malonic acid, Prostaglandin E2 and Sphingosine were identified as potential metabolic markers for distinguishing the GCA and healthy control (AUC=0.976, sensitivity =0.913, specificity =0.027, optimal cut off value=0.470). Conclusions: This work was first identified 12 metabolites significant correlated with survival and 17 metabolites for potential auxiliary diagnosis for GCA. In addition, arginine biosynthesis pathway metabolism showed important roles in GCA. Results provide the understanding of the molecular difference between GCA and healthy control. The novel plasma biomarkers panel could clearly distinguish GCA patients from the healthy control group. This finding may form the basis for the development of a minimally invasive method for GCA detection.
Metagenomic Community Composition and Resistome Analysis in a Full-scale Cold Climate Wastewater Treatment Plant
Authors: Uyaguari Miguel 
Published: October 2021

Abstract
Background: Wastewater treatment plants are an essential part of maintaining the health and safety of the general public. However, they are also an anthropogenic source of antibiotic resistance genes. In this study, we characterized the resistome, the distribution of classes 1-3 integron-integrase genes (intI1, intI2, and intI3) as mobile genetic element biomarkers, and the bacterial and phage community compositions in the North End Sewage Treatment Plant in Winnipeg, Manitoba. Samples were collected from raw sewage, returned activated sludge, final effluent, and dewatered sludge. A total of 28 bacterial and viral metagenomes were sequenced over two seasons, fall and winter. Integron-integrase genes, the 16S rRNA gene, and the coliform beta-glucuronidase gene were also quantified during this time period. Results: Bacterial classes observed above 1% relative abundance in all treatments were Actinobacteria (39.24% ± 0.25%), Beta-proteobacteria (23.99% ± 0.16%), Gamma-proteobacteria (11.06% ± 0.09%), and Alpha-proteobacteria (9.18 ± 0.04%). Families within the Caudovirales order: Siphoviridae (48.69% ± 0.10%), Podoviridae (23.99% ± 0.07%), and Myoviridae (19.94% ± 0.09%) were the dominant phage observed throughout the NESTP. The most abundant bacterial genera (in terms of average percent relative abundance) in influent, returned activated sludge, final effluent, and sludge, respectively, includes Mycobacterium (37.4%, 18.3%, 46.1%, and 7.7%), Acidovorax (8.9%, 10.8%, 5.4%, and 1.3%), and Polaromonas (2.5%, 3.3%, 1.4%, and 0.4%).The most abundant class of antibiotic resistance in bacterial samples was tetracycline resistance (17.86% ± 0.03%) followed by peptide antibiotics (14.24% ± 0.03%), and macrolides (10.63% ± 0.02%). Similarly, the phage samples contained a higher prevalence of macrolide (30.12% ± 0.30%), peptide antibiotic (10.78% ± 0.13%), and tetracycline (8.69% ± 0.11%) resistance. In addition, intI1 was the most abundant integron-integrase gene throughout treatment (1.14x104 gene copies/mL) followed by intI3 (4.97x103 gene copies/mL) while intI2 abundance remained low (6.4x101 gene copies/mL).Conclusions: The wastewater treatment plant successfully reduced the abundance of bacteria, DNA bacteriophages, and antibiotic resistance genes although many of them still remained in effluent and biosolids. The presence of integron-integrase genes throughout treatment and in effluent suggests that antibiotic resistance genes could be actively disseminating resistance between both environmental and pathogenic bacteria.
Comparative aspects of treatment of endometrial hyperplasia in women of reproductive age with overweight
Authors: Semeniuk Andrii 
Published: October 2021

The aim. Minimization of the frequency of recurrence of endometrial hyperplasia (EH) in women of reproductive age with overweight (OW) depending on the tactics of treatment.
Materials and methods. 90 women of reproductive age with endometrial hyperplasia and OW were selected. They, in turn, were divided into three groups: group 1 – 30 women who took a gonadotropin-releasing hormone agonist (GnRH agonist), namely at a dose of 3.75 mg intramuscularly once every 28 days; group 2 – 30 women who used progestin (norethisterone) at a dose of 10 mg per day from day 16 to 25 of the cycle, group 3 – 30 women who took combined oral contraception (COC) (30 mcg ethinyl estradiol and 150 mcg desogestrel) in a cyclic mode 21/7.
Evaluation of the effectiveness of therapy included a clinical picture of the disease 6 months after the start of treatment, assessment of the variability of the average values of endometrial thickness and uterine size on ultrasound (US) of the pelvis 6 months after treatment. Also analyzed the effectiveness of therapy based on the results of morphological examination of the endometrium in a biopsy of the uterine mucosa, performed 6 months after the start of treatment. In addition, a general analysis of the frequency of EH recurrence was performed 6–24 months after treatment.
Results. The results showed that in the group in which women were prescribed GnRH agonist, there was a significantly higher effectiveness of treatment, in particular the absence of uterine bleeding and menstrual disorders (MD). At the same time, in the other norethisterone group, 53.3 % (16) of women had intermenstrual uterine bleeding. In patients in the group in which women received COC, uterine bleeding was observed in 30.0 % (i.e. 9) of patients (p <0.05).
Immediately after treatment, the average values of endometrial thickness in patients of group 1, according to ultrasound, was 3.59±0.47 mm, which was significantly less than in women of groups 2 and 3 – 6.81±0.59 mm (p<0.001) and 7.58±0.69 mm (p<0.001).
In addition, patients in group 1 at 3, 6, 12, 24 months after the end of hormone therapy were registered significantly lower average values of endometrial thickness, compared with patients receiving norethisterone and estrogen-progestogen drugs.
Conclusions. In a comparative evaluation of the effectiveness of treatment of endometrial hyperplastic processes in overweight women, it was found that the recurrence rate after 6–24 months occurs in 6.7 % (i.e. 2) of patients after GnRH agonist therapy, in 33.3 % (i.e. in 10) patients receiving norethisterone (p<0.001), and in 50 % (i.e. 15) of women treated with COC (p<0.001).
Effect of hydrodynamic breakage on floc evolution and turbidity reduction in flocculation and sedimentation processes
Authors: Zhang Xinran , Zhu Jiaqi , Li Zhenxing , Li Junyi , Ren Pengfei 
Published: October 2021

Abstract
Coagulation and sedimentation process is one of the most popular processes in drinking water treatment. Hydrodynamic breakage has a significant impact on the evolution of floc characteristics and the efficiency of turbidity removal. In this work, the effects of hydrodynamic breakage on floc size, fractal dimension, and floc morphology were investigated with an in-situ recognition system. The experiments were conducted in a continuous flocculation and sedimentation reactor equipped with perforated plates to provide different hydrodynamic breakage conditions. The experimental results indicated that the hydrodynamic conditions significantly influenced the floc destabilization and restructuring processes. A low hydrodynamic shear force provided by P1 led to the increase of both bigger sized flocs but accompanied with small particles (0–10 μm). Excessive velocity gradient provided by P3 produced smaller and looser flocs. An appropriate velocity gradient (i.e., the flow velocity through the perforated plate P2 at 18.9 × 10−3m s−1) was conducive for the formation of larger and more compact structures, with higher average floc size and fractal dimension. This flocculation condition in turn resulted in effective improvements in the turbidity removal efficiency. Floc evolution models were described based on the mechanism of the breakage and restructuring process.
Assessment of sustainability index for rural water management using ANN
Authors: Raghavendra Kumar R. , Kumar Gaurav , Gupta Rajiv 
Published: October 2021

Abstract
The current study proposes a sustainability index (SI) measure based on artificial neural networks (ANN) and globally accepted parameters. Some of the available methods for SI measurement are multi-criteria analysis, external costs, energy analysis, and ecological footprint methods. However, validity remains a concern due to a system's needs, criteria, and requirements. Generally, sustainability is assessed in economic, environmental, and social issues, which varies across regions and countries. Most of the studies accept sub-indices but to a limited extent. Therefore, the proposed study develops an SI evaluation method based on the idea of multi-sustainability incorporating operations, institutions, risks, and climate factors besides economic, environmental, and social issues. All these issues might not be applicable to a single project but may help to develop a complete index when applied. The present study considered different scenarios in building a method to calculate SI using ANN. The results obtained by the ANN model for various input parameters helped to identify the best water conservation strategy. Sensitivity analysis was also performed to determine the uncertainty contribution/significance of the input variables for the water scarcity in the study region. The developed model in the study is tested on a rural water management system.
Szkolnictwo polonijne w Kanadzie w XIX-XX w. (cz. 1)
Authors: Gliński Waldemar 
Published: October 2021

Pierwsza polska szkoła w Kanadzie powstała w parafii powołanej w 1875 r. dla przybyłych w okolice Barry’s Bay osadników z polskich Kaszub. Wraz z napływem polskich emigrantów i powstawaniem na ich potrzeby parafii etnicznych tworzono przy nich szkoły: w 1894 r. w Kitchener, w 1901 r. w Winnipeg, w 1913 r. w Toronto (przy kościele św. Stanisława Kostki), w 1938 r. w Oshavie. Przed wybuchem II wojny światowej w prowincji Ontario powstały szkoły jeszcze szkoły polskie w Thunder Bay (1933 r.), trzy w Hamilton (w 1927 r., w 1936 r. i w 1937 r.). Kolejne szkoły powstały w Brandfort (w 1936 r.), w Preston (w 1934 r.), w Delhi (w 1939 r.), w London (1927), w Sudbury (1936 r.), w Brandford (1928 r.), w Albercie (1913 r.), w Montrealu (1915 r.), w Calgary (w 1934 r.), gdzie już w początkach XX stulecia mieszkało ponad 7 tys.
A New Mode of Thinfilm and Nanofiber for Burst Release of the Drug for
Alzheimer Disease; A Complete Scenario from Dispersible Polymer to
Formulation Methodology
Authors: AnjiReddy Keshireddy , Subramanian S. Karpagam 
Published: October 2021

:
Alzheimer's Disease (AD) is usually caused by intellectual deterioration which occurs due
to the degeneration of cholinergic neurons. Donepezil is employed for cholinesterase enzyme Inhibition
(ChEI) to treat AD in a wider population. Over the years, researchers finding difficulties prompted
through traditional dosage forms particularly in geriatric patience. To avoid swallowing difficulties
brought about with the aid of the AD population, researchers majorly focused on Oral Thin-Film
technology (OTF). This technology strongly eliminates issues caused by solid oral dosage forms. It is
one of the quality strategies to alternate a drug that is used in the first-pass metabolism or pre systematic
metabolism. The solubility of the drug is a bigger problem and it can expand by way of lowering
particle size. Nanofibers are need of the day to minimize the drug particles at the submicron stage
which can increase the drug release rate drastically. It can be prepared by Electrospinning technology
by incorporating polymeric material into poorly soluble drugs. Mostly natural and biodegradable polymers
prefer in all pharmaceutical preparations. Polymers employed for oral delivery should be stable,
possess mucoadhesive properties, and should release the drug by diffusion, degradation, and swelling
mechanism. The objective of the present review explains various thin-film and nanofiber formulations
used for faster drug release in the treatment of Alzheimer's disease.
TREATMENT OF AORTA MESENTERIC COMPRESSION: CURRENT PROBLEMS AND PROSPECTS
Authors: Nesterenko I. R. 
Published: October 2021

Left renal vein compression between the aorta and the superior mesenteric artery at an acute angle of the origin of the latter (“the nutcracker syndrome”) often leads to phlebohypertension in the left renal vein causing a combination of structural and functional changes in the kidneys and pelvic organs, different clinical manifestations such as left-sided varicocele, hematuria, pelvic venous congestion syndrome, the development of renal failure.
The objective of the research: to determine indications for surgical and conservative treatment of aorta mesenteric compression.
Materials and methods. The study included 210 patients (142 men and 68 women) with suspected “nutcracker syndrome” who were referred to vascular surgeons for a consultation by urologists and gynecologists during the period from 1999 to 2020, mainly from the western regions of Ukraine (about 11 million population). The age of the patients ranged from 12 to 52. All patients were interviewed for specific complaints: pain in the left lumbar region and left half of abdomen, inability to eat large amounts of food, hematuria, proteinuria, hemospermia, erectile dysfunction, left sided varicocele in men, and left sided pudendal varicosity and dysmenorrhea in women. All referred patients with suspected “nutcracker syndrome” underwent color Doppler ultrasound to determine the presence of pathological reflux in the left renal and gonadal veins by measuring peak systolic velocities in order to confirm or exclude that pathology. The patients with confirmed left renal vein stenosis underwent CT angiography.
Results. According to color Doppler ultrasound, different degree of aorta mesenteric compression was confirmed in 138 (65.7%) patients (83 men and 55 women), critical left renal vein stenosis was observed in 35 of them. Two patients were diagnosed with the retroaortic left renal vein (“posterior nutcracker”).
According to observations, clinical manifestations of AMC syndrome severe forms occurred in case of an increase in the diameter of the distal part of the LRV compared to its proximal segment by 3-6 times as well as in case of an increase in peak systolic velocity in the stenosed proximal segment by 6-14 times (by 8.7 times on average) compared to the left renal vein distal segment.
Conclusions. Color Doppler ultrasound with determination of peak systolic velocities and diameters of the left renal and gonadal veins, pathological reflux in them must be the obligatory diagnostic stage in the patients with suspected AMC. The choice of treatment approach should be made taking into account clinical and laboratory indices, as well as the assessment of AMC severity according to instrumental data (ultrasound, CT angiography, MRA, etc.). The severity of pathomorphological changes in the pelvic organs and their consequences proves the need to eliminate phlebohypertension in the left renal and gonadal veins. LRV transposition proves its effectiveness in the remote postoperative period.