bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kualitas post-thawing semen domba Merino dalam bahan pengencer berbasis susu skim-kuning telur yang ditambah isolat crude protein Tirosine Kinase
Authors: Widiantoro Krisna , Madyawati Sri Pantja , Sardjito Trilas , Hernawati Tatik , Triana Indah Norma , Warsito Sunaryo Hadi 
Published: August 2021

This study was conducted to determine the effect of crude protein tyrosine kinase (PTK) isolates supplementation into skim milk-egg yolk based diluent to maintain the quality of Merino ram spermatozoa. Four ejaculates of two Merino rams were divided into two groups for the control group (P0): Merino ram semen was diluted in skimmed milk-egg yolk based diluent, and the treatment group (P1): Merino ram semen was diluted in skim milk-egg yolk based diluent contained crude PTK 1,597 mg/ml diluent. All diluted semen was equilibrated for 2 hours at 5 °C and filled into 0.25 mL French straws. The filled straws were placed on steel racks (Cooltop, Minitube) held in liquid nitrogen vapour for 10 minutes at –140 °C, immersed immediately in liquid nitrogen at –196 °C, and stored for 48 hours for later assessment. Post-thawed semen samples were evaluated for spermatozoa motility, viability, and morphological abnormality. The results showed that the spermatozoa motility of fresh semen of Merino ram was 82.5 ± 2.89, which was qualified for freezing. The post-thawing spermatozoa motility, viability, and morphological abnormalities of Merino ram in the P1 group were 34.11 ± 3.26%, 38.00 ± 3.00%, and 12.89 ± 4.54%, respectively. It were higher (p <0.05) than the control group of 24.44 ± 2.9%, 26.67 ± 3.32%, and 21.11 ± 3.02%. It was concluded that the addition of crude PTK isolates of 1.597 mg/ml skim milk-egg yolk diluent improved the quality of post-thawed spermatozoa of Merino ram.
Pendugaan sebaran intrusi air laut melalui sungai di desa Ujungmanik kecamatan Kawunganten kabupaten Cilacap menggunakan metode geolistrik resistivitas konfigurasi Wenner
Authors: Sehah Muhammad , Syahfitri Mitha , Sunardi Sunardi 
Published: August 2021

The estimation of the distribution of the sea water intrusion through the rivers in Ujungmanik Village, Kawunganten District, Cilacap Regency has been carried out using the Wenner configuration resistivity geoelectric. This research aims to estimate the distribution of sea water intrusion through rivers in Ujungmanik Village, Kawunganten District, Cilacap Regency based on geoelectric resistivity and conductivity data of groundwater. The geoelectric data acquisition was carried out on four lines. They were Wen1 Line, Wen2 Line, Wen3 Line, and Wen4 Line. Each line had a range of 200 meters. The results of geoelectric data processing showed that the subsurface rock structure consisted of sand, clay, sandy loam, and sandy clay. The Seawater intrusion shown by the sand layer occurred in all trajectories which had a range of resistivity value of 0.20 - 2.79 Ωm. Groundwater samples was carried out at fifteen points with the conductivity value varies between 1363 - 4145 µS / cm so that they can be classified that the water was fresh and brackish due to the sampling done in the rainy season. From this research it can be implied that the entire Ujungmanik area is evenly intruded by the sea water at the coordinates 7º38ꞌ15.62ꞌꞌLS 108°57ꞌ20.89ꞌꞌBT to 7º39ꞌ22.86ꞌꞌLS 108º56ꞌ35.33ꞌꞌBT.
Eksplorasi sumber air tanah bawah perbukitan kapur (karst) menggunakan metode geolistrik resistivitas konfigurasi Schlumberger di desa Darmakradenan kecamatan Ajibarang kabupaten Banyumas
Authors: Sehah Muhammad , Ratsanjani Hastani 
Published: August 2021

Penelitian menggunakan metode geolistrik resisitivitas telah dilakukan untuk mengetahui struktur batuan bawah permukaan serta potensi air tanah di Desa Darmakradenan Kecamatan Ajibarang Kabupaten Banyumas. Konfigurasi yang digunakan pada metode ini adalah konfigurasi Schlumberger sebanyak lima lintasan dengan panjang masing-masing 200 m. Hasil pemodelan secara inversi telah menghasilkan log resistivitas yang terdiri atas enam lapisan batuan bawah permukaan. Lapisan-lapisan batuan tersebut diinterpretasi sebagai tanah penutup dengan nilai resistivitas sebesar 206.8 – 1204.92 Ωm, batukapur dengan nilai resistivitas sebesar 767.51 – 1563.65 Ωm, kerikil dan pasir dengan nilai resistivitas sebesar 270.84 Ωm, lempung dengan nilai resistivitas sebesar 319.39 – 473.97 Ωm, batupasir gampingan dengan nilai resistivitas sebesar 17.22 Ωm, dan napal dengan nilai resistivitas sebesar 814.17 – 982.94 Ωm. Potensi sumber air tanah diperkirakan hanya terdapat di titik S-L1 dan S-L2 yang merupakan lapisan batupasir gampingan dengan nilai resitivitas 17.22 – 47.02 Ωm pada kedalaman 11.80 – 70.00 m dan diinterpretasi sebagai akuifer dangkal
Rancang bangun sistem peringatan kemiringan menara dan overload jembatan gantung berbasis sensor kemiringan dan sensor massa
Authors: Saefurrahman Haris , Hartono Hartono , Abdullatif Farzand 
Published: August 2021

Sistem peringatan kemiringan menara dan overload jembatan gantung berbasis sensor kemiringan dan sensor massa telah dibuat. Sistem peringatan memanfaatkan sensor Load Cell sebagai alat pengukur massa di atas jembatan gantung dan sensor kemiringan MPU6050 sebagai alat pengukur kemiringan menara jembatan gantung. Mikrokontrol arduino digunakan sebagai pusat kendali sistem elektronika, sekaligus sebagai pengatur fungsi logika peringatan untuk mengaktifkan LED, buzzer dan LCD. Hasil penelitian sistem diperoleh ADC dari sensor kemiringan MPU6050 dan tegangan keluaran dari sensor Load Cell guna mengetahui fungsi kalibrasi sensor. Hasil uji karakteristik statik sensor kemiringan dan sensor massa memiliki rata-rata nilai akurasi sebesar 96,39% dan 99,55%, presisi sebesar 96,33% dan 99,55%, error sebesar 3,61%dan 0,45% serta waktu respon sebesar 1 detik dan 2 detik.
The challenges of teaching and learning during a pandemic become an opportunity: reflections on a student and academic partnership.
Authors: Getti Giulia Tullia Marianna , Harris Sarah , Alexandru Ioana-Cristina , Boulas Raphaelle , Huckstepp Rebekah , Gandhi Vishwa Hiteshbhai , Pires Piedade Ana , Brempong Louise , Tresserras Segura Clara , Ugwuanyi Adanonso 
Published: August 2021

The current pandemic has forced us to implement major changes in the way we communicate, interact and work, all of which have had a massive impact upon all aspects of our lives. Academics and students alike have had to adapt very quickly to the new situation and the challenges encountered, although viewed from different perspectives, are largely similar. Changes are often unsettling and taxing, especially when they are not the result of a personal choice, but they can also offer great opportunities, the most significant of which is for lecturers and learners to develop best practice together, in partnership (Kurczek and Johnson, 2014). This article reflects upon how sharing our experience of a students-and-staff partnership at the University of Greenwich 2021 SHIFT conference has affected our experience of teaching and learning during a pandemic.
A Study on the Electrical Characteristics of Fractured Gas Hydrate Reservoirs Based on Digital Rock Technology
Authors: Yang Hu , Xue Xiaojun , Chen Xianghui , Xie Junyu , Zheng Qinglong 
Published: August 2021

Abstract
The electrical characteristics of fractured gas hydrate reservoirs were investigated through the diffusion-limited aggregation model, digital rock technology, and the finite element method. The results show that the fracture and gas hydrate have a significant effect on the electrical characteristics of rock partially saturated with gas hydrate, where the matrix pore and fracture mixed gas hydrate form a dual-porosity system. Due to the fracture and gas hydrate effect, the electrical characteristics of fractured gas hydrate reservoirs cannot be described well by traditional Archie equations. The resistivity index vs. water saturation curve of fractured gas hydrate reservoirs shows a nonlinear relationship for different gas hydrate pore habits (pore-filling, cementing, and grain-coating types), and this curve consists of two parts with different gas hydrate saturation exponents for pore-filling and cementing gas hydrate and presents a curve without a fixed water saturation exponent for grain-coating gas hydrate. Fractured gas hydrate reservoirs with different fracture apertures, different gas hydrate pore habits, and saturation features will lead to macroscopic electrical anisotropy. The results of theoretical analysis and numerical simulation show that the electrical anisotropy coefficient of fractured gas hydrate reservoirs is a function of gas hydrate saturation. The function curve consists of three segments with the turning point for pore-filling and cementing gas hydrate, and this curve can be divided into two parts through the turning point. The findings of this study can help for a better understanding of the electrical characteristics of fractured gas hydrate reservoirs, which have great significance for the exploration and development of gas hydrate resources.
Mesoporous silica from Parangtritis beach sand templated by CTAB as a support of Mo Metal as a catalyst for hydrocracking of waste palm cooking oil into biofuel
Authors: Alisha Gesha Desy , Trisunaryanti Wega , Syoufian Akhmad 
Published: August 2021

Abstract
In this study, natural source Parangtritis beach sand was extracted into mesoporous silica (MS). Synthesis of mesoporous silica (MS) was carried out at sodium silicate: CTAB ratio of 1:0.5 (w/w). Monometallic catalyst was used to improve the performance of the catalyst. The monometallic used was Mo metal, which was synthesized using the wet impregnation method. Catalysts were characterized using FTIR, XRD, Surface Area Analyzer (SAA), SEM-EDX, and TEM. MS has pore diameters and surface area of 2.62 nm and 897.3 m2/g. Mo/MS has pore diameters, surface area, and Mo metal concentration of 2.46 nm, 593 m2/g, and 4.75 %. Catalytic activity and selectivity were evaluated in hydrocracking of waste palm cooking oil at 500, 550, and 600 oC, and catalyst: waste palm cooking oil ratio of 1:100, 1:200, and 1:300. The best catalyst will be tested for reusability 3 times through the hydrocracking process. Mo/MS produces better liquid products and hydrocarbon compounds than MS. The results of the conversion of liquid products analyzed using GCMS. The yield of liquid products obtained in the hydrocracking of waste palm cooking oil using Mo/MS with the optimum temperature and the weight ratio of catalyst: feed at 550oC and 1: 300 was 66.99 wt.% with consists of hydrocarbon compound as 62.79 wt.%. The yield of liquid products obtained in the hydrocracking waste palm cooking oil using the used Mo/MS catalyst in the last run was 80.26 wt.% with consist of hydrocarbon compound as 74.13 wt.%.
The Deceleration of Radio/Light Transmission; A Collision Mechanism Dependent Radio Signal Emission, Transmission, and Reception
Authors: Zhang Jing 
Published: August 2021

Abstract
The fast and slow fading of radio signal transmissions or laser beam itself and its spare light confirm the presence of two kinds of collisions --- electron-photon and photon-photon collision. Photon transmissions of radio signals are either in consecutive dense photon groups in slow fading process or widespread group pattern in fast fading form. The photon transmission shapes are irregular and dynamical changes. The radio frequency shift and the wavelength reduction by the calculation demonstrate decelerations of radio/light transmission speeds due to the gradual reduced distance between two consecutive photon groups along the transmission pathway. Photons from radio signals are able to affect electron movements in radio signal receiving process and electrons able to kick photons into space during radio signal emission. The pattern of free electron movement under the influence of local electromagnetic force in antenna is consistent with the randomly dynamic changes of radio signal in space. The fast fading is due to the collision of consecutive photon groups of signals in slow fading with free photons in space. The shape changes of radio signal peaks suggest photons able to remain in transmission photon groups after photon-photon collision, leading to deceleration transmissions in slow fading. The mathematical equation for the relationship between light/radio transmission speeds before and after photons collisions is established. The equation is confirmed by the calculations of well-known difference of light transmission speeds in different media. The gravities from Earth and Sun play little role during light/radio transmission.
The Effects of Aerobic Training and Omega-3 Intake on Aβ42, Neprilysin, and γ- Secretase in the Hippocampus of Male Rats Alzheimer's model
Authors: yaghoubi ali 
Published: August 2021

Abstract
Alzheimer's disease (AD) is characterized by excessive deposition of the amyloid-β peptide (Aβ) in the central nervous system and reducing its level is the goal of many medications. Thus this study aimed to investigate the effect of aerobic training and omega-3 intake on Aβ42, Neprilysin, and γ-secretase in the hippocampus of male rats Alzheimer's model. 50 male wistar rats (12weeks-old and weight 222.31±11.91 g), divided into 5 groups including, control Alzheimer's (AC), Alzheimer's with the omega-3 intake (AO), Alzheimer training (AT), Alzheimer's with omega-3 intake, and Alzheimer training (AOT) and Healthy Control (HC). Alzheimer's disease induced by injection of homocysteine (60mM) into the rat brain ventricle. Training with a speed of 20 m/min (60 minutes and 5 days/week on the treadmill) was applied. The supplement group was received an Omega-3 supplement 800mg/kg of body weight, daily for eight weeks. Level of Aβ42, γ-secretase, and Neprilysin protein measured using ELISA method. In data analysis, a one-way ANOVA and Tukey test as a post hoc were used (P<0.05). The obtained results showed that the level of Aβ42 in the hippocampus of AC was significantly higher than the HC group (P=0.001). Also, the level of the Aβ42 in the hippocampus of AC was significantly higher than AO, AT, and AOT groups (P values 0.001, 0.007, and 0.003 respectively). Also the γ-Secretase level in the hippocampus of AC was significantly higher than the HC group (P=0.001). Also, the γ-secretase levels in the hippocampus of the AC group were significantly higher than AO, AT, and AOT groups (P values, 0.002, 0.001, and 0.001 respectively). There was no significant difference between Neprilysin levels of the hippocampus of research groups (P = 0.534). It appears that exercise training and omega-3 consumption, can prevent amyloidogenic pathways by reducing the level of γ-secretase, and lead to reducing the level of Aβ hippocampus of Alzheimer's disease subjects. In total, aerobic exercise training and omega-3 intake can be studied as complementary therapy in Alzheimer's patients.
Identification of Most Lethal Non-synonymous SNPs in Tollip gene- An In-Silico Analysis
Authors: Ghani Usman , Ullah Rahmat , Anjum Tayyaba , Ali Yasir , Sabar Muhammad Farooq , Khan Shehryar , Zulfiqar Iqra 
Published: August 2021

Abstract
The Toll-interacting protein (TOLLIP), first detected by hybrid screening using Interleukin-1 receptor accessory protein in 2000, is ubiquitous and its TLR signaling cascade gets negatively regulated by TOLLIP in particular by impeding the TLR4 and TLR2 pathways. Toll-interacting protein facilitates TLR and TGF-β type 1 receptor intracellular localization and lysosomal degradation and exerts its anti-apoptosis and pro-autophagy effects through interaction with a target of Myb1 membrane trafficking protein 1 (TOM1) in autoimmunity. It also protects intestinal epithelial cells from apoptosis induced by (TNF-α) (IFN-γ) signaling and acts as a cargo adaptor linking (ATG8) autophagy gene 8 and microtubule-associated protein 1 light chain 3. Ubiquitin-modified cell debris along with coated autophagosomes removes harmful protein aggregates and maintains cellular homeostasis. It is therefore structurally and functionally important to detect TOLLIP polymorphisms to indicate the possible malfunctions and therapeutics. We have identified the gap of available data on nsSNPs in the TOLLIP gene in previous studies. Hence, We have used a wide range of bioinformatic techniques in this study to identify the most destructive nsSNPs in the TOLLIP gene. The in-silico tools such as PROVEAN, SIFT, SNP&GO, PhD SNP, and PolyPhen2 have been used followed by I Mutant, MutPred, and ConSurf. The 3-D mapping was carried out with I-TASSER and Phyre2. Though, STRING and GeneMANIA proposed the gene to gene interaction of TOLLIP. Our study identified G19D (rs866744102), G32R (rs1308704061), D71N (rs777772934), and E72G (rs1202660177) as the four most lethal non-synonymous SNPs in TOLLIP genes, which may play an essential part in defects of TOLLIP Protein and probably cause a different type of diseases. This is the first study of its kind, and it could pave the way in the field of medical drugs in the future. The influence of these nsSNPs in the normal functioning of TOLLIP can also be evaluated in animal models to identify the underlying biochemical pathway involved in diseases.
Peak ependymal cell stretch overlaps with the onset location of periventricular white matter lesions
Authors: Visser Valery , Rusinek Henry , Weickenmeier Johannes 
Published: August 2021

Abstract
Deep and periventricular white matter hyperintensities (dWMH/pvWMH) are bright appearing white matter tissue lesions in T2-weighted fluid attenuated inversion recovery magnetic resonance images and are frequent observations in the aging human brain. While early stages of these white matter lesions are only weakly associated with cognitive impairment, their progressive growth is a strong indicator for long-term functional decline. DWMHs are typically associated with vascular degeneration in diffuse white matter locations; for pvWMHs, however, no unifying theory exists to explain their consistent onset around the horns of the lateral ventricles. We use patient imaging data to create anatomically accurate finite element models of the lateral ventricles, white and gray matter, and cerebrospinal fluid, as well as to reconstruct their WMH volumes. We simulated the mechanical loading of the ependymal cells forming the primary brain-fluid interface, the ventricular wall, and its surrounding tissues at peak ventricular pressure during the hemodynamic cycle. We observe that both the maximum principal tissue strain and the largest ependymal cell stretch consistently localize in the anterior and posterior horns. Our simulations show that ependymal cells experience a loading state that causes the ventricular wall to be stretched thin. Moreover, we show that maximum wall loading coincides with the pvWMH locations observed in our patient scans. These results warrant further analysis of white matter pathology in the periventricular zone that includes a mechanics-driven deterioration model for the ventricular wall.
Research on the Construction of the Capacity of General Practice Trainers of Community Training bases in China
Authors: Rao Xin , Su Qiaoli , Li Shuangqing , Wang Xingyue 
Published: August 2021

Abstract
Background: To explore the construction of the trainers' ability system of the community practice base of general practice under the background of hospital / community integrated teaching of general practice. Methods: literature analysis, Delphi discussion and questionnaire survey were used in the study, and exploratory factor analysis was used to extract competency. Results: there are 4 first level indicators and 20 second level indicators in the system, among which the first level indicators are: personal characteristics and professionalism, teaching and research ability, basic level clinical practice ability, and base organization management ability. Conclusion: the index system enriches the theory of teachers' ability in community practice base of general practice medicine, and provides empirical research basis for the selection, ability training and performance evaluation of teachers in community practice base of general practice medicine.
Moderating Effect of Vigorous Physical Activity on Health Care Costs among Adolescents: ABCD Growth Study
Authors: Chagas Lucas Gabriel Moraes , Fernandes Rômulo Araújo , Araujo Monique Yndawe Castanho , Torres Wésley , Urban Jacqueline Bexiga , Maillane-Vanegas Santiago , Turi-Lynch Bruna Camilo , Codogno Jamile Sanches , Anokye Nana Kwame 
Published: August 2021

Abstract
Background: The relationship between physical activity and health care costs among adolescents is not yet clear in the literature.Objective: To analyze the relationship between physical activity and annual health care costs among adolescents.Methods: The present sample was composed of 85 adolescents of both sexes with ages ranging from 11 to 18 years (mean age 15.6±2.1). Health care costs were self-reported every month for 12 months, and information on health care values was verified at local pharmacies, private health care plans, and the National Health Service. The time spent in different physical activity intensities was objectively measured by accelerometers. Confounding variables were: sex, age, somatic maturation, body fatness, blood pressure, and components of dyslipidemia and insulin resistance. Multivariate models were generated using generalized linear models with gamma distribution and a log-link function.Results: The overall annual health care cost was US$ 733.60/ R$ 2,342.38 (medication: US$ 400.46 / R$ 1,278.66; primary and secondary care: US$ 333.14 / R$ 1,063.70). The time spent in vigorous physical activity (minutes/day) was negatively related to health care costs (r= -0.342 [95% CI: -0.537, - 0.139]; β= -0.06 cents (95% CI: -0.089, -0.031).Conclusion: Vigorous physical activity seems to be associated with lower health care costs among adolescents.
Extraoral Photobiomodulation for Prevention of Oral and Oropharyngeal Mucositis in Head and Neck Cancer Patients: Interim Analysis of A Randomized, Double-Blind, Clinical Trial
Authors: Kauark-Fontes Elisa , Migliorati Cesar Augusto , Epstein Joel B , Treister Nathaniel Simon , Alves Carolina Guimarães Bonfim , Faria Karina Morais , Palmier Natalia Rangel , Rodrigues-Oliveira Leticia , Paglioni Mariana de Pauli , Gueiros Luiz Alcino Monteiro , Vasconcelos Karina Gondim Moutinho da Conceição , Leme Adriana Franco Paes , de Castro Gilberto , Lopes Marcio Ajudarte , Prado-Ribeiro Ana Carolina , Brandão Thais Bianca , Silva-Santos Alan 
Published: August 2021

Abstract
PurposeTo assess the safety and efficacy of prophylactic extraoral photobiomodulation (PBM) for the prevention of oral and oropharyngeal mucositis (OM) on clinical outcomes and survival in patients with oral cavity and oropharyngeal squamous cell carcinoma (OOPSCC).MethodsOOPSCC patients who received radiotherapy (RT) were prospectively randomized to two groups: prophylactic extraoral PBM and placebo. OM grade (NCI), pain (VAS), analgesia, and anti-inflammatory prescriptions were assessed weekly. Quality of life questionnaires (QoL) were performed at the first and last day of RT. Following RT, participants were evaluated quarterly for oncological outcomes follow-up.Results55 patients met the inclusion criteria. The first occurrence of OM was observed at week 1, for the placebo group (p = 0.014). Later OM onset and severity was observed for the PBM group, with first occurrence at week 2 (p = 0.009). No difference in severe OM incidence was observed (p > 0.05). Lower mean pain score was noted at week 7 for the PBM group (2.1) compared to placebo group (4.5) (p = 0.009). Less analgesics (week 3; p = 0.009/week 7; p = 0.02) and anti-inflammatory prescription (week 5; p = 0.0346) were observed for the PBM group. Better QoL scores were observed for the PBM group at last day of RT (p = 0.0034). No difference in overall survival among groups, was observed in one year of follow-up (p = 0.889).ConclusionProphylactic extraoral PBM can delay OM onset, reduce pain, as well as reduced analgesic and anti-inflammatory prescription requirements. Extraoral PBM was associated with better QoL. There was no evidence of PBM impact on oncological outcomes. TRN:RBR-4w4swx (date of registration: 01/20/2020)