bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fault Traces: Generation of Fault Segments and Estimation of Their Fractal Dimension
Authors: Zhu Weiwei , Yalcin Bora , Khirevich Siarhei , Patzek Tad W. 
Published: August 2021

AbstractFault damage zones have a higher upscaled permeability than the host rock because of a higher fracture intensity therein. Fracture distribution in the damage zone depends highly on the geometry of fault segments. However, precise images of architectural elements of large-scale faults at depth are difficult to obtain by seismic acquisition and imaging techniques. We present a numerical method that generates fault segments at multiple scales from an imprecise fault trace based on the fractal properties of these segments. The generated fault segments demonstrate hierarchical self-similar architecture, and their lengths follow approximately a lognormal distribution. These characteristics are similar to real fault segments observed in outcrops and seismic surveys. An algorithm that covers fault segments accurately with the minimum number of circles is proposed to calculate the fractal dimensions for both natural and computer-generated faults. The fractal dimensions of natural and generated fault segments are similar and range between 1.2 and 1.4.
Numerical and Experimental Study on the Effects of Rheological Behavior of Drilling Fluid on the Performance of the Fluidic Down-the-Hole Hammer
Authors: Ge Dong , Peng Jianming , Zhang Guang , Cheng Jingqing , Zhang Pengyu , Bo Kun 
Published: August 2021

Summary
In the field of oil and gas exploration, the fluidic down-the-hole (DTH) hammer has frequently been used to solve the challenges associated with hard rock drilling and excessive friction along the drillstring. Appropriate performance prediction for drilling tools is particularly important for the drilling operation. Previous experiments showed that the performance prediction scheme determined by the water was not accurate for fluidic DTH hammer driven by mud, which is a typical pseudoplastic power-law fluid. Based on the results, compared with water, the rheological behavior of the pseudoplastic power-law fluid can be significant for the flow behavior in the fluidic oscillator with a lower supply flow rate. However, for a normal or higher level of supply flow rate, because of the shear diluting effect of the pseudoplastic power-law fluid, the influence of rheology behavior of drilling mud on the performance of fluidic DTH hammer was not apparent. The temperature of the drilling fluid and barite weighting agent can also affect the performance of the fluidic DTH hammer by affecting the rheological properties of the drilling mud. In this paper, numerical simulation and experiments are used for qualitative discussion and conclusion verification, respectively.
Daily Precipitation Concentration in Central Coast Vietnam
Authors: Benhamrouche Aziz , Martin-Vide Javier , Pham Quoc Bao , Kouachi Mostefa E. , Moreno-Garcia M. Carmen 
Published: August 2021

Abstract
Empirical frequency distribution of daily precipitation amounts can be fitted by a negative exponential distribution, because anywhere there are many small daily totals and few large ones. Therefore, the cumulative percentages of days with precipitation, sorted in increasing order according to their amounts, against the cumulative percentage of the rainfall amounts that they contribute are fitted by positive exponential curves Y = aX, a and b constants. Based on these curves, the Concentration Index (CI) evaluates the contribution of the rainiest days to the total amount. In this study the CI has been calculated for 15 meteorological stations in Da Nang city and Quang Nam province in Central Coast Vietnam, for the 1979–2016 period. The results show high values of CI, ranging from 0.62 to 0.72. Conversely, the linear correlation between altitude and CI is negative (R=-0.60, p < 0.01). There are no correlations between the latitude nor the annual mean number of precipitation days and the CI. CI change for the sub-periods of 1979–1997 and 1998–2016 is also analyzed.
The Difference of Antibiotic Resistance Genes in Gut Microbiota Among Yak, Beef and Dairy Cattle by Metagenomic Approach
Authors: Wang Weiwei , Wei Xiaojuan , Wu Lingyu , Shang Xiaofei , Cheng Fusheng , Li Bing , Zhou Xuzheng , Zhang Jiyu 
Published: August 2021

Abstract
The drug resistance has been partly driven by the overuse of antimicrobials in agricultural feeding. Better understanding of the antibiotic resistance in gut of bovine is needed to assess its potential effects based on metagenomic approach and analysis. In this study, we collected 40 fecal samples to explore the drug resistance deriving from antibiotics in bacterial community by an analysis of the diversity and difference of antibiotic resistant genes (ARGs) in gut microbiota from yak, beef and dairy cattle. 1688 genes were annotated, including 734 ARG subtypes in summary. The ARGs were related with tetracycline, quinolone, β-lactam, aminoglycoside, in accordance with the antibiotics widely used in clinic for humans or animals. The emergence, prevalence and differences in resistance genes in the intestines of yaks, beef and dairy cattle may be caused by the selective pressure of different feeding patterns. Additionally, the abundance of ARGs in yak was lower than in beef and dairy cattle, while the abundance of integron, a kind of mobile genetic elements (MGEs), was higher than those in beef and dairy cattle. Furthermore, the results of this study demonstrated that a comprehensive profile of various ARGs among yak, beef and dairy cattle for providing a basic research.
Suicidality In Individuals With Prader-Willi Syndrome: A Review of Registry Survey Data
Authors: Peleggi Analise , Bohonowych Jessica , Strong Theresa , Schwartz Lauren , Kim Soo-Jeong 
Published: August 2021

Abstract
BACKGROUND: Prader–Willi syndrome (PWS) is a rare, genetic, neurodevelopmental syndrome associated with hyperphagia and early onset obesity, growth and sex hormone insufficiencies, mild-to-moderate intellectual disability, and behavioral challenges such as compulsivity, anxiety, skin picking, social skills deficits and temper outbursts. Given high rates of psychiatric comorbidity and potential risk factors for suicide in PWS, this study sought a first estimate of the prevalence of suicidal ideation (SI) and attempts (SA) in the PWS population and any characteristics associated with suicidality in this population. METHODS: Using the Global Prader-Willi Syndrome Registry, we included all participants who had answered a question about SI. We examined the most recent data from the surveys about social, economic, and demographic factors, genetic subtype, and psychiatric symptoms and treatments. A chi-square analysis was used to compare registry participants who reported SI to those without reported SI. RESULTS: From 750 included survey respondents, 94 (12.5%) endorsed some history of SI. Of these, 25 (26.6%) also reported a history of SA, with an average age of 16.25 years at their first attempt. Those with a history of SI were predominantly male and adult age, and had higher rates of aggression and psychiatric comorbidities, therapies, and medications. CONCLUSIONS: This study indicates that the rate of SI and SA in PWS is comparable to the general population, and that suicide attempts in PWS typically begin in middle-teenage years. Despite unique challenges, individuals with PWS and their caregivers should be included in screens and psychoeducation for suicide and mental health concerns.
Evaluating Sewage Sludge Contribution During Co-Composting Using Cause-Evidence-Impact Analysis Based on Morphological Characterization
Authors: Balaganesh Pandiyan , MANGOTTIRI VASUDEVAN , Natarajan Narayanan 
Published: August 2021

Abstract
The methods of compost preparation from sewage sludge and their modes of application to the agricultural fields have profound impacts on the soil ecology and environment. Besides their chemical conditioning effect on soil organic matter, they also impart physical attributes to the soil texture and structure. Though it is expected that compost addition improves water holding capacity and nutrient sequestration, there is lack of clarity in correlating the outcomes with conditions of excess nutrient storage/leaching despite the benefits on crop yield. In this study, we present a systematic cause-evidence-impact relationship on the feedstock, processing and applications of co-composted organic matter. Various analytical tools were compared to elucidate the unique characteristics of co-composted sewage sludge to get a realistic understanding of the complex soil-compost interactions. Results from the spectroscopic characterization reveal the implications of selection of bulking agents and sludge pre-treatment in determination of the final quality of the compost. The results attribute significant parent material influence to the formation of well-defined porous structures. The impacts of compost quality on the soil and crop can be proactively determined in terms of elemental composition, functional groups and stability indices. Thus the present approach provides good scope for customizing compost preparations and applications to get the preferred field outputs.
Association between Conventional Oxygen Therapy and Characteristics and Outcomes of Adult Patients in a Surgical Intensive Care Unit
Authors: Stroh Lubov , Nurjadi Dennis , Uhle Florian , Bruckner Thomas , Weigand Markus A. , Fiedler Mascha O. 
Published: August 2021

Abstract
Background: Oxygen therapy is often used in emergency departments and intensive care units. The prevention of hypoxia with associated complications remains the main target, but a high-concentrated usual oxygen therapy seems not to be the best strategy. We hypothesize that physiological pressure of arterial oxygen (paO2) reduces mortality, onset of new infections and organ dysfunctions in critically ill patients compared with supraphysiological paO2.Methods: In this retrospective exploratory cohort study we included 112 critically ill adult patients treated in a surgical critical care unit. All patients were assigned to two groups defined a priori based on paO2 mean values measured in the first 24 hours of mechanical ventilation: first group paO2 75-100 mmHg (n=43), second group patients with paO2 > 100mmHg (n=69). Primary outcome was the cumulative survival, defined from the day of admission in the intensive care unit (ICU) until death or end of the hospital stay. Secondary outcome was the incidence of infections and new organ dysfunctions in both groups. Results: The baseline characteristics like age, body mass index (BMI), lactate and severity of disease scores were similar in both groups. A total of 27 of 69 patients (39,1%) in the group paO2 > 100mmHg and 12 of 43 patients (27,9%) in the group paO2 75-100mmHg died during their ICU stay or further hospital stay (p=0.54). There were no statistically significant differences in the incidence of new infections and new organ dysfunctions between the two groups. Positive end expiratory pressure (PEEP) and fraction of inspired oxygen (FiO2) were in the group of patients with paO2 > 100mmHg significantly lower 8,4 mbar vs. 9,5 mbar (p=0.03).Conclusions: There was no significant increase in overall mortality or new onset of infections and organ dysfunctions in critically ill adult ICU patients requiring oxygen therapy with supraphysiological paO2 (> 100 mmHg) compared to patients with physiological paO2 (75-100 mmHg). Further studies are needed to define the optimal paO2 parameter.
Preoperative Chemoradiation With Image-guided IMRT in Patients With Locally Advanced Gastric Cancer
Authors: SHEN Jing , LIAN Xin , GUAN Qiu , PANG Tingtian , HE Lei , DONG Tingting , SHEN Jie , ZHANG Fuquan 
Published: August 2021

Abstract
PurposeTo evaluate the efficacy and toxicity of preoperative chemoradiation with image-guided IMRT in locally advanced resectable gastric cancer patients.Patients and methodsPatients with locally advanced (T3/T4 or N+) gastric cancer treated with neoadjuvant chemoradiotherapy followed by surgery between Jan 2013 and June 2019 in PUMCH were retrospectively analyzed. Radiotherapy(IMRT 45Gy/25#/5weeks) were delivered with megavolt computed tomography performed before every delivery to ensure the accuracy repeatability of gastric filling during treatment, with concurrent chemoctherapy(Capecitabine alone or XELOX*2 cycles). ResultsA total of 95 patients were included in the study with 93 patients (97.9%) had stage cT3/T4, 85 patients (89.5%) had stage N+.The location of the tumors was in the upper 1/3 in 85 patients (89.5%). Alltogether 93/95(97.9%) patients finished the neoadjuvant chemoradiation, 80 patients (84.2%) underwent gastric resection(58 D2 and 22 D1 gastrectomy). Pathology downstaging was observed in 68 patients (85.0%), including 66 patients (82.5%) with T downstaging and 56 patients (70.0%) with N downstaging. 11 patients (13.75%) obtained pathological complete response (pCR). The median follow-up was 44.7 months (19-96 months). Compared with the clinical efficacy of neoadjuvant chemotherapy in the previous literature, the clinical efficacy of image-guided IMRT combined with concurrent chemotherapy in patients with locally advanced resectable gastric cancer was improved, the 5-year OS, LRFS, and DMFS rates of patients were 46.98% (95% CI: 38.60%-55.36%), 86.55% (95% CI: 79.11%-93.99%), and 60.71% (95% CI: 51.49%-69.93%), respectively.Grades 3-4 leukopenia, anemia,and thrombocytopenia were observed in 13 (13.68%) patients, 9 (9.47%) patients, and 5 (5.26%) patients, respectively. Multivariate analysis demonstrated that pCR was significant prognostic factor for OS (HR =11.211, 95% CI: 1.500–83.813, P = 0.024).ConclusionCompared with the previous literature results of preoperative neoadjuvant chemotherapy for patients with gastric cancer, the application of image-guided IMRT(45Gy/25#/5weeks) combined with chemotherapy in preoperative neoadjuvant therapy for patients with locally advanced gastric cancer can achieve improved clinical efficacy, with higher rates of OS, LRFS, and DMFS, good tolerance of concurrent chemoradiotherapy with acceptable side effects.
Impact of Delayed Initiation of Non-Invasive Ventilation for Respiratory Distress in Outborn Late-Preterm and Term Neonates
Authors: Choi Eui Kyung , Park Kyu Hee , Choi Byung Min 
Published: August 2021

Abstract
The frequency of non-invasive ventilation (NIV) use increased in neonates of all gestational ages with respiratory distress (RD). However, the impact of delayed initiation of NIV support in outborn neonates remains poor understood. The aim of the present study was to identify the impact of delayed initiation of NIV in outborn late-preterm and term neonates. The medical records of 277 infants (gestational age of ≥ 35 weeks) who were received NIV as primary respiratory therapy <24 h of age between 2016 and 2020 were retrospectively reviewed. Among the 190 outborn neonates, the factors associated with respiratory adverse outcomes were investigated. Infants with RD divided into two groups, mild (FiO2 ≤0.3) and moderate-to-severe RD group (FiO2 >0.3), depending on initial oxygen requirement under NIV support. Median time to start of NIV support at tertiary center was 3.5 (2.2–5.0) h. Male sex (odds ratio [OR], 2.9; 95% CI, 1.1–7.7), high oxygen requirement (FiO2 >0.3) (OR, 4.8; 95% CI, 1.5–15.3), and respiratory distress syndrome (OR, 10.4; 95% CI, 3.9–27.8) were the significant factors associated with adverse outcomes. Subgroup analysis revealed that in the moderate-to-severe RD group, delayed initiation of NIV (≥3 h) was significantly associated with pulmonary air leakage (p=0.033).Conclusions: Our study shows that outborn neonates with moderate-to-severe RD who were treated with delayed NIV were associated with an increased likelihood of pulmonary air leakage. Additional prospective studies are needed to establish the optimal timing and methods of NIV support for outborn late-preterm and term infants.
A feasibility Randomised Controlled Trial of a Fibromyalgia Self-management Programme in a community setting with a nested qualitative study (FALCON)
Authors: Pearson Jennifer , Coggins Jessica , Derham Sandi , Russell Julie , Walsh Nicola , Lenguerrand Erik , Palmer Shea , Cramp Fiona 
Published: August 2021

Abstract
Background Fibromyalgia is a condition associated with widespread musculoskeletal pain, fatigue and sleep problems. Fibroymyaglia treatment guidelines recommend non-pharmacological interventions and the development of self-management skills. The Fibromyalgia Self-management Programme (FSMP) consists of one 2.5-hour weekly session over six successive weeks and includes education about fibromyalgia, goal setting, pacing, sleep hygiene and nutritional advice. The FSMP is currently provided in a secondary care hospital setting and co-delivered by a multidisciplinary team. Delivery in a primary care setting has the potential to improve the accessibility of the programme to people with fibromyalgia. Therefore, this feasibility study aimed to determine the practicality and acceptability of conducting a future definitive randomised controlled trial of the FMSP in a community setting.MethodAn exploratory, parallel-arm, one-to-one, randomised controlled trial. Participants were recruited from general practices across South West England, and the FSMP was co-delivered by physiotherapists and occupational therapists across two community sites. To determine the outcome measures for a future definitive trial several were tested. All clinical outcome measures were patient-reported and collected at baseline, six weeks and six months. Semi-structured interviews were conducted with patient participants, occupational therapists and physiotherapists to explore the acceptability and feasibility of delivering the FMSP in a community setting.Results A total of 74 participants were randomised to the FSMP intervention (n=38) or control arm (n=36). Attrition from the trial was 42% (31/74) at six months. A large proportion of those randomised to the intervention arm (34%, 13/38) failed to attend any sessions with six of the 13 withdrawing before the intervention commenced. The proportion of missing values was small for each of the outcome measures. Three overarching themes were derived from the interview data; (1) barriers and facilitators to attending the FSMP; (2) FSMP content, delivery and supporting documentation; and (3) trial processes.Conclusion Findings indicate that it is feasible to recruit people with fibromyalgia from primary care to participate in a randomised controlled trial testing the clinical and cost-effectiveness of the FSMP delivered in a community setting. However, improvement in trial attrition and engagement with the intervention is needed. Trial registration: The trial is registered with ISRCTN registry and was assigned on 29/04/2019. The registration number is ISRCTN10824225.
Detecting potential reference list manipulation within a citation network
Authors: Wren Jonathan , Georgescu Constantin 
Published: August 2021

Abstract
Although citations are used as a quantifiable, objective metric of academic influence, references could be added to a paper to inflate the perceived influence of a body of research. This reference list manipulation (RLM) could take place during the peer-review process, or prior to it. Surveys have estimated how many people may have been affected by coercive RLM at one time or another, but it is not known how many authors engage in RLM, nor to what degree. By examining a subset of active, highly published authors (n = 20,803) in PubMed, we find the frequency of non-self citations (NSC) to one author coming from one paper approximates Zipf’s law, permitting the task to be approached statistically. Framed as an anomaly detection problem, higher confidence is gained the more outlier status is correlated across dimensions relative to non-outliers. We find the NSC Gini Index correlates highly with anomalous patterns across multiple RLM-related distributions. Between 81 (FDR < 0.05) and 231 (FDR < 0.10) authors are outliers on the curve, suggestive of chronic, repeated RLM. Approximately 16% of all authors may have engaged in RLM to some degree. Authors who use 18% or more of their references for self-citation are significantly more likely to have NSC Gini distortions, suggesting a potential willingness to coerce others to cite them.
Case Report: Post SARS-CoV2 Infection Erythema Nodosum
Authors: Sarvestani Aida Askari , Ghotbabadi Shabnam Hajiani 
Published: August 2021

Abstract
Background: Although, preliminary reports of Post SARS-CoV2 Infection Erythema Nodosum suggest it may be due to dysregulated immune response caused by coronavirus.Case presentation: The patient was a 9-year-old boy who referred to the pediatric Rheumatology clinic of Shiraz University of Medical Sciences due to bilateral painful erythematous nodules on his bilateral calves. He reported a history of fever from 4 days before his referral which was followed by erythema, warmth, stiffness, and swelling of his calves. The patient’s father had afflicted COVID-19 two months prior to the incidence. In his course of admission, COVID-19 serology tests were performed for him which was positive for SARS-CoV-2 IgG and negative for SARS-CoV-2 IgM.Conclusion: Another etiologic factor for EN might be coronaviruses such as SARS-CoV-2 which is important to be taken into consideration during the COVID-19 pandemic.
Treating PTSD With Imagery Rescripting During An Underweight State In Eating Disorder Patients. A Multiple Baseline Case Series Study
Authors: Napel Marieke ten , Vroling Maartje , Mares Suzanne HW , Arntz Arnoud 
Published: August 2021

Abstract
Background; Eating disorder patients with a posttraumatic stress disorder have worse treatment results regarding their eating disorder than patients without a posttraumatic stress disorder. Many underweight eating disorder patients with co-morbid posttraumatic stress disorder symptoms are not treated for their posttraumatic stress disorder symptoms during underweight. We pose that posttraumatic stress disorder treatment in underweight eating disorder is possible, and tested whether posttraumatic stress disorder symptoms decrease with Imagery Rescripting, and secondary whether the treatment of trauma has an effect on the process of weight gain and on eating disorder pathology in general.Method; Ten patients in clinical treatment (BMI 14-16.5) participated. A multiple baseline design was used, with baseline varying from six to 10 weeks, a six-week treatment phase, a three-week follow-up period and a three month follow-up measurement. Data were analyzed with mixed regression. Results; Evidence was found for strong effects of treating posttraumatic stress disorder symptoms with imagery rescripting without interfering with the eating disorder treatment. Positive effects were also found on a range of emotional and cognitive secondary measures.Conclusion;Imagery rescripting of traumatic memories at times of underweight was possible, safe and had positive clinical effects. Trial registrationNetherlands trial register (NTR) Trial NL5906 (NTR6094). Date of registration 09/23/2016. https://www.trialregister.nl/trial/5906