bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacto da pandemia da COVID-19 na qualidade de vida, saúde e renda nas famílias com e sem risco socioeconômico: estudo transversal
Authors: Greco Ana Luiza Righetto , Silva Carolina Fioroni Ribeiro da , Moraes Murilo Mageste de , Menegussi Juliana Moraes , Tudella Eloisa 
Published: April 2021

Objetivo: Comparar a qualidade de vida, a percepção da saúde e renda entre famílias com e sem risco socioeconômico durante a pandemia da COVID-19. Métodos: Participaram deste estudo transversal 41 mães de lactentes nascidos a termo saudáveis (≥ 37 semanas), as quais foram subdivididas em dois grupos: 1) de risco socioeconômico (G-R); e 2) sem risco socioeconômico (G-SR). A qualidade de vida foi mensurada por meio do instrumento World Health Organization Quality of Life-Bref (WHOQOL-Bref). A percepção da saúde e renda mensal foi mensurada por meio de um questionário elaborado pelos autores. Resultados: Foi encontrada diferença significativa entre os grupos G-R e G-SR para o domínio meio ambiente (p= 0,001) no WHOQOL-Bref. A percepção sobre a saúde durante a pandemia da COVID-19 de mães do G-R foi entre boa (52,6%) e regular (36,8%) enquanto a maioria das mães no G-SR avaliou a saúde como boa (81,8%). Das famílias sem risco socioeconômico, 59% precisaram recorrer ao auxílio do governo enquanto que a maioria das famílias de baixo NSE (89,5%) foi beneficiada com o auxílio emergencial do governo. Conclusões: Famílias de baixo nível socioeconômico apresentaram pior qualidade de vida no que diz respeito ao domínio meio ambiente, pior percepção sobre a saúde, e renda familiar diminuída quando comparadas com famílias sem risco socioeconômico.
Produção e caracterização físico-química de geleia de menta enriquecida com spirulina (Spirulina platensis)
Authors: Bú Steffany Albuquerque do , Felinto Ana Clara Bezerra , Marçal Eduarda Josefa Alves , Oliveira Igor Macêdo de , Lima Joyce Almeida , Sousa Juliana Barbosa de , Melo Wagner Gomes de , Cavalcanti Mayra da Silva 
Published: April 2021

Existe uma grande preocupação com um estilo de vida mais saudável por uma parte crescente dos indivíduos. Nesse contexto, suplementos vitamínicos e alimentos enriquecidos figuram como possibilidades práticas de potencializadores nutritivos. A Spirulina Platensis apresenta alta concentração de nutrientes e é um dos mais completos suplementos naturais disponíveis na natureza. Sendo assim, a produção de um alimento com boa aceitabilidade, como a geleia, figura como uma alternativa para suplementar a Spirulina, haja vista que o cheiro e cor forte de sua forma não processada muitas vezes atrapalham a sua utilização na alimentação. Com esse objetivo, foi elaborada no presente estudo uma geleia de menta enriquecida com Spirulina (Spirulina platensis) em diferentes formulações. Para averiguação das formulações foram feitos teste físico-químicos (teor de água e sua atividade, cinzas, Sólidos solúveis, proteína e acidez) e microbiológicos, estes últimos seguiram o preconizado pela legislação vigente. As características físico-químicas se mostraram enquadradas nos padrões estabelecidos pela legislação, fator que contribui para a formação de aspectos sensoriais agradáveis e desejáveis, tornando a geleia viável para consumo. Foram obtidos também resultados positivos nos estudos microbiológicos, onde os resultados estavam dentro dos parâmetros adequados, evidenciando a qualidade das geleias, da matéria-prima e do processo produtivo. Tendo em vista tais dados, pode-se concluir que a geleia deste estudo tem um alto teor nutricional, podendo tornar-se futuramente uma grande auxiliar na suplementação nutricional da população.
Políticas públicas de assistência estudantil: a percepção de discentes de uma Universidade Federal do Ceará, Brasil
Authors: Maluf Samia Nagib , Xavier Antonio Roberto , Victor Dijane Maria Rocha 
Published: April 2021

O presente artigo tem por objetivo avaliar a trajetória de desenvolvimento de políticas públicas de assistência estudantil no âmbito da Universidade da Integração Internacional da Lusofonia Afro-brasileira (Unilab), através da implantação do Programa de Assistência Estudantil (PAES). Para tanto, realizou-se, metodologicamente, um estudo de caso tipologicamente exploratório de abordagem quali-quanti com emprego do instrumento do questionário para coleta/geração de dados, estatística descritiva no tocante a técnica de análise quantitativa e análise do discurso crítico concernente à parte qualitativa. No tocante aos resultados, alcançou-se que a contribuição do PAES para 93.4%, consideram que estar no programa contribui para o desenvolvimento das atividades acadêmicas; 96.7% responderam que se os benefícios fossem retirados, não conseguiriam manter-se na Universidade; 96.2%, entendem que o programa tem favorecido para a permanência na universidade; e, 76% consideram que a concessão dos auxílios afeta positivamente no desempenho acadêmico, o que corrobora com o fato de que 84% deles apresentam um Índice de Desempenho Estudantil (IDE) superior a 7,0 (sete). Por fim, considera-se que o estudo apresenta elementos que podem subsidiar os gestores nas tomadas de decisões e reflexões, contribuir para criação de mecanismos de monitoramento, controle e de revisão.
Smart Home With Smart Control, Berbasis Bluetooth Mikrokontroller
Authors: Adi Barep , Herlina Amalia 
Published: April 2021

Sistem rumah cerdas (Smart Home) adalah sistem aplikasi gabungan antara teknologi dan pelayanan yang dikhususkan pada lingkungan rumah dengan fungsi tertentu yang bertujuan meningkatkan efesiensi, kenyamanan dan keamanan penghuninya. Sistem rumah cerdas terdiri dari perangkat control dan otomatisasi beberapa perangkat atau peralatan rumah yang dapat diakses melalui sebuah komputer.Sistem dibangun dengan menggunakan mikrokontroller arduino dan dengan perangkat pendukung seperti relay, bluetooth, kabel jumper, lampu rumah, smartphone, komputer dan laptop. arduino dijadikan sebagai pengontrol (otak) yang menjalankan perintah yang digunakan untuk mengontrol lampu rumah. Pengontrolan dilakukan melalui aplikasi smartphone, yang terhubung dengan arduino melalui jaringan bluetooth. Relay berfungsi sebagai saklar untuk menyalakan dan memadamkan lampu rumah yang terhubung dengan arduino melalui pin-pin. Melalui pin-pin perintah menyalakan dan memadamkan lampu yang diterima dari arduinol diteruskan ke relay dengan memberikan logika 1 (HIGH) yang berarti menyala dan logika 0 (LOW) yang berarti padam.Dari hasil pengujian dapat disimpulkan bahwa lampu dapat dinyalakan dan di padamkan melalui aplikasiyang berjalan di android pada arduino yang diakses melalui aplikasi pada smartphone, melalui jaringan bluetooth.
Rancang Bangun Indikator Berat, Temperatur Dan Kadar Alkohol Pada Proses Fermentasi Singkong (Tape) Dengan Metode Fuzzy Berbasis Microcontroller Atmega 16
Authors: Isnainin Nurul , Ulum Miftachul , Joni Koko 
Published: April 2021

Pada umumnya, dalam pembuatan tape para produsen tape masih menggunakan cara manual sehingga kualitas tape sering mengalami prubahan hal ini disebabkan karena ada beberapa faktor yaitu kondisi suhu, ragi yang dibutuhkan serta kadar alkohol yang terkandung dalam tape untuk menentukan tingkat kematangan tape. Permasalahan yang dialami produsen tape dapat dilakukan suatu pengendalian rancang bangun sistem dalam proses fermentasi dengan menggunakan 3 buah sensor. Metode yang di gunakan dalam penelitian ini adalah metode fuzzy tsukamoto. Penelitian skripsi ini bertujuan proses fermentasi dapat di lakukan secara otomatis dengan merancang bangun suatu sistem kendali pengontrol suhu, kadar alkohol dan persbandingan ragi yang di gunakan. Pengontrolan sistem alat ini dilakukan oleh mikrokontroler ATMega 16 mempunyai 3 input berbentuk sensor DHT11, sensor MQ-3 dan input berbentuk sensor load cell, sensor DHT11 ini akan mendeteksi suhu, sedangkan sensor load cell mendeteksi berat singkong yang berada dalam inkubator dan ditampilkan pada LCD dan untuk sensor MQ-3 dapat menentukan kematangan tape. Hasil penelitian ini menunjukan bahwa ragi yang baik untuk digunakan fermentasi adalah 4 gram persatu kilogram singkong. Hasil rancang bangun alat ini lebih efisien 58.29% dari pada fermentasi secara manual.
Redesain Speed Control Submerged Scraper Conveyor (Ssc) Bottom Ash Menggunakan Ac Drive
Authors: Reza Fahrizal , Imaduddin Ilmi Rizki 
Published: April 2021

Sistem kontrol penggerak Submerged Scrapper Conveyor (SSC) mempunyai peran yang sangat vital dalam proses kerja transportasi material limbah abu berat (bottom-ash) yang merupakan sisa hasil pembakaran batubara di boiler. Sistem kontrol penggerak SSC bekerja secara kontinyu 24 jam untuk menjaga agar material bottom ash tidak menumpuk di boiler hopper . Sistem ini harus selalu dijaga kehandalannya, karena apabila bermasalah maka akan berdampak langsung pada keberlangsungan operasi boiler di pembangkit yaitu menyebabkan derating.Sistem kontrol penggerak eksisting pada SSC menggunakan speed variator. Speed variator bekerja secara mekanis untuk mengatur kecepatan dari SSC yaitu dengan sistem hidrolik transmisi. Kecepatan perlu diatur untuk mengendalikan laju material bottom ash akibat variasi beban pembangkit. Apabila beban tinggi, maka material bottom ash akan lebih banyak dibanding pada beban rendah. Sistem penggerak SSC di PLTU Paiton Unit 1 dan 2 dengan speed variator dewasa ini banyak mengalami permasalahan. Mulai dari overheating, kerusakan inner part, hingga spare part yang sudah tidak tersedia (obsolete), selain itu penurunan nilai kalori batubara yang dipakai pada boiler juga menambah beban pada SSC dikarenakan limbah bottom ash yang semakin banyak.Untuk memaksimalkan kehandalan SSC di PLTU Paiton, maka dilakukan redesain speed control SSC. Redesain ini dilakukan dengan mengganti sistem kontrol penggerak SSC yang lama, yaitu speed variator dengan VFD (variable frequency drive) atau motor drive AC (Alternating Current). Redesain tersebut terdiri dari beberapa tahap, antara lain: (i) melakukan penggantian peralatan pada sistem kontrol penggerak SSC antara lain motor SSC serta mengganti speed variator dengan VFD, (ii) memodifikasi wiring dan logic pada PLC sistem untuk mengontrol kecepatan SSC, (iii) melakukan modifikasi panel kontrol sehingga operasi SSC dapat dimonitor di CCR Fly Ash HMI Human Machine Interface dan local control station baik secara auto atau lokal.
Rancang Bangun Pendeteksi Formalin Dan Rhodamin B Berbasis Arduino
Authors: Susanto Rizky . , Baskoro Farid . 
Published: April 2021

Formalin dan rhodamin b merupakan bahan kimia berbahaya yang paling sering disalah gunakan sebagai bahan tambahan pangan sesuai dengan laporan BPOM 2017 yang menunjukkan penyalahgunaan rhodamin mencapai 36% sedangkan formalin mencapai 32% padahal hal ini sudah dilarang oleh pemerintah yang telah tertuang dalam SK maupun peraturan kemenkes. Alat ini bermanfaat untuk membantu masyarakat dalam mendeteksi formalin dan rhodamin b, dengan desain yang kecil dan memiliki sumber daya internal alat ini bisa dibawa ke berbagai tempat dengan mudah dan dioperasikan secara langsung tanpa mencari sumber daya PLN. Alat ini memanfaatkan sensor MQ-138 yang berupa sensor gas untuk mendeteksi formalin dan photodiode untuk mendeteksi rhodamin b dengan arduino nano sebagai pusat pengendali dan hasilnya ditampilkan melalui OLED( Organic Light-Emitting Diod). Pada pengujian formalin memiliki nilai error 7% - 17% pada bahan tahu, ikan, dan mie basah dengan konsentrasi formalin yang berbeda – beda pada tiap bahan dimana pada bahan tahu memiliki akurasi 86%- 92% sementara pada bahan ikan memilki nilai akurasi antara 88% - 93% dan pada bahan mie basah memiliki akurasi antara 83% - 90%. Pengujian rhodamin b menggunakan 3 larutan dengan konsentrasi yang berbeda – beda dengan hasil pengujian menunjukkan error antara 24% - 27% dari ketiga bahan tersebut. Pada alat ini menggunakan 1 buah rechargeable battery dengan kapasitas 3000mAh yang mampu bertahan selama 8 jam
Paroxysmal Sympathetic Hyperactivity in Severe Anti-N-Methyl-d-Aspartate Receptor Encephalitis: A Single Center Retrospective Observational Study
Authors: Wang Dongmei , Su Shuang , Tan Miaoqin , Wu Yongming , Wang Shengnan 
Published: April 2021

BackgroundParoxysmal sympathetic hyperactivity (PSH) is a disorder with excessive sympathetic activity commonly recognized in patients with acquired brain injury. Autonomic instability is frequent in anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDARE). However, PSH in anti-NMDARE has gained little attention.MethodsWe retrospectively reviewed 24 patients diagnosed with severe anti-NMDARE in the neuro-intensive care unit (NICU) between 2014 and 2019. Patients were assessed with the PSH assessment measure (PSH-AM) scale, and categorized into “PSH+” group and “PSH-” group. The clinical characteristics, hospital mortality, and functional outcome by modified Rankin Scale (mRS) score at six months after discharge were compared between the two groups. Among patients with PSH+, the clinical features and pharmacotherapy of PSH were summarized and compared.ResultsTwenty-four patients were included in the study. Twelve of them (50%) were categorized as PSH+ based on PSH-AM scores. There were no significant differences in the demographic characteristic, GCS scores upon admission, incidence of status epilepticus, teratoma occurrence, hospital mortality, and 6-month mRS between PSH+ and PSH- groups. Patients with PSH+ had increased length of NICU stay, hospital stay and duration of mechanical ventilation. The most prominent clinical features of PSH in severe anti-NMDARE were tachycardia and hyperthermia, while posturing was the relatively mildest clinical feature. Propranolol and clonazepam were more commonly used than gabapentin in pharmacotherapy of PSH in severe anti-NMDARE.ConclusionsThe incidence of PSH in severe anti-NMDARE patients was as high as 50%. Patients with PSH demonstrated prolonged NICU stay, hospital stay and increased duration of mechanical ventilation, while no effect on hospital mortality and functional outcome. Clinicians should be aware of the distinctive characteristics and treatment options of PSH in severe anti-NMDARE.
Methodological Issue of Mitochondrial Isolation in Acute-Injury Rat Model: Asphyxia Cardiac Arrest and Resuscitation
Authors: Aoki Tomoaki , Okuma Yu , Becker Lance B. , Hayashida Kei , Shinozaki Koichiro 
Published: April 2021

Background: Identification of the mechanisms underlying mitochondrial dysfunction is key to understanding the pathophysiology of acute injuries such as cardiac arrest (CA); however, effective methods for measurement of mitochondrial function associated with mitochondrial isolation have been debated for a long time. This study aimed to evaluate the dysregulation of mitochondrial respiratory function after CA while testing the sampling bias that might be induced by the mitochondrial isolation method.Materials and Methods: Adult rats were subjected to 10-min asphyxia-induced CA. 30 min after resuscitation, the brain and kidney mitochondria from animals in sham and CA groups were isolated (n = 8, each). The mitochondrial quantity, expressed as protein concentration (isolation yields), was determined, and the oxygen consumption rates were measured. ADP-dependent (state-3) and ADP-limited (state-4) respiration activities were compared between the groups. Mitochondrial quantity was evaluated based on citrate synthase (CS) activity and cytochrome c concentration, measured independent of the isolation yields.Results: The state-3 respiration activity and isolation yield in the CA group were significantly lower than those in the sham group (brain, p &lt; 0.01; kidney, p &lt; 0.001). The CS activity was significantly lower in the CA group as compared to that in the sham group (brain, p &lt; 0.01; kidney, p &lt; 0.01). Cytochrome c levels in the CA group showed a similar trend (brain, p = 0.08; kidney, p = 0.25).Conclusions: CA decreased mitochondrial respiration activity and the quantity of mitochondria isolated from the tissues. Owing to the nature of fragmented or damaged mitochondrial membranes caused by acute injury, there is a potential loss of disrupted mitochondria. Thus, it is plausible that the mitochondrial function in the acute-injury model may be underestimated as this loss is not considered.
Social Disconnectedness, Loneliness, and Mental Health Among Adolescents in Danish High Schools: A Nationwide Cross-Sectional Study
Authors: Santini Ziggi Ivan , Pisinger Veronica S. C. , Nielsen Line , Madsen Katrine Rich , Nelausen Malene Kubstrup , Koyanagi Ai , Koushede Vibeke , Roffey Sue , Thygesen Lau C. , Meilstrup Charlotte 
Published: April 2021

Background:Previous research has suggested that social disconnectedness experienced at school is linked to mental health problems, however, more research is needed to investigate (1) whether the accumulation of various types of social disconnectedness is associated with risk for mental health problems, and (2) whether loneliness is a mechanism that explains these associations.Methods:Using data from the Danish National Youth Study 2019 (UNG19), nation-wide cross-sectional data from 29,086 high school students in Denmark were analyzed to assess associations between social disconnectedness experienced at school (lack of classmate support, lack of teacher support, lack of class social cohesion, and not being part of the school community) and various mental health outcomes, as well as the mediating role of loneliness for each type of disconnectedness. Multilevel regression analyses were conducted to assess the associations.Results:Descriptive analyses suggest that 27.5% of Danish high school students experience at least one type of social disconnectedness at school. Each type of social disconnectedness was positively associated with mental health problems (depression symptoms, anxiety symptoms, stress, sleep problems, suicidal ideation, non-suicidal self-injury, eating disorder, body dissatisfaction, and low self-esteem) and negatively associated with mental well-being. In all cases, loneliness significantly mediated the associations. We found a clear dose-response pattern, where each addition in types of social disconnectedness was associated with (1) stronger negative coefficients with mental well-being and (2) stronger positive coefficients with mental health problems.Conclusion:Our results add to a large evidence-base suggesting that mental health problems among adolescents may be prevented by promoting social connectedness at school. More specifically, fostering social connectedness at school may prevent loneliness, which in turn may promote mental well-being and prevent mental health problems during the developmental stages of adolescence. It is important to note that focusing on single indicators of school social connectedness/disconnectedness would appear to be insufficient. Implications for practices within school settings to enhance social connectedness are discussed.
Baseline Cerebral Ischemic Core Quantified by Different Automatic Software and Its Predictive Value for Clinical Outcome
Authors: Shi Zhang , Li Jing , Zhao Ming , Zhang Minmin , Wang Tiegong , Chen Luguang , Liu Qi , Wang He , Lu Jianping , Zhao Xihai 
Published: April 2021

PurposeThis study aims to investigate the agreement of three software packages in measuring baseline ischemic core volume (ICV) and penumbra volume (PV), and determine their predictive values for unfavorable clinical outcome in patients with endovascular thrombectomy (EVT).MethodsPatients with acute ischemic stroke who underwent computed tomographic perfusion (CTP) were recruited. Baseline CTP measurements including ICV and PV were calculated by three software packages of IntelliSpace Portal (ISP), Rapid Processing of Perfusion and Diffusion (RAPID), and fast-processing of ischemic stroke (F-STROKE). All patients received EVT, and the modified Rankin scale (mRS) at 90 days after EVT was assessed to determine the clinical outcomes (favorable: mRS = 0–2; unfavorable: mRS = 3–6). The agreement of CTP measurements among three software packages was determined using intraclass correlation coefficient (ICC). The associations between CTP measurements and unfavorable clinical outcome were analyzed using logistic regression. Receiver operating characteristic curves were conducted to calculate the area under the curve (AUC) of CTP measurements in predicting unfavorable clinical outcome.ResultsOf 223 recruited patients (68.2 ± 11.3 years old; 145 males), 17.0% had unfavorable clinical outcome after EVT. Excellent agreement between F-STROKE and RAPID was found in measuring ICV (ICC 0.965; 95% CI 0.956–0.973) and PV (ICC 0.966; 95% CI 0.956–0.973). ICVs measured by three software packages were significantly associated with unfavorable clinical outcome before (odds ratios 1.012–1.018, all P &lt; 0.01) and after (odds ratios 1.003–1.014, all P &lt; 0.05) adjusted for confounding factors (age, gender, TOAST classification, and NIHSS on admission). In predicting unfavorable clinical outcome, ICV measured by F-STROKE showed similar performance to that measured by RAPID (AUC 0.701 vs. 0.717) but higher performance than that measured by ISP (AUC 0.629).ConclusionsThe software of F-STROKE has excellent agreement with the widely used analysis tool of RAPID in measuring ICV and PV. The ischemic core volume measured by both F-STROKE and RAPID is a stronger predictor for unfavorable clinical outcome after EVT compared to ISP.
Case Report: Next-Generation Sequencing Reveals Tumor Origin in a Female Patient With Brain Metastases
Authors: Li Qun , Zhang Xiaoyan , Feng Jiao , Cheng Dezhi , Cai Lin , Dai Zhang’an , Zhao Shuyu , Li Jianmin , Huang Jingjing , Fang Yu , Zhu Honglin , Wang Danhua , Wang Sizhen , Ma Tonghui , Lu Xianghe 
Published: April 2021

BackgroundBrain metastasis mainly originates from lung cancer. Napsin A and TTF-1 factors have frequently been detected in lung adenocarcinoma cases. Brain metastasis tumors with napsin A and TTF-1 positive are easily classified as lung adenocarcinoma origin. However, some thyroid cancers also exhibit these clinical features. Besides, lung is the most common metastasis of undifferential thyroid cancer. Therefore, it requires development of novel diagnostic tools to aid in distinguishing between pulmonary and thyroid origin.Patient FindingsWe reported a case that was initially diagnosed as brain metastatic lung cancer based on immunohistochemistry results. Analysis of next-generation sequencing (NGS) data from the brain lesion revealed that the cancer may have originated from the thyroid. We detected combo mutations in TERT promoter mutation, RET fusion and TP53, which are common in undifferential thyroid cancer (UTC), but rare for lung cancer. These results, coupled with identification of PAX8, indicated that this patient had UTC. Additionally, her three sons, despite being asymptomatic, were all diagnosed with papillary thyroid carcinoma.SummaryThe patient received anlotinib treatment and showed good clinical outcomes. One month after anlotinib treatment, the pulmonary nodules were found to be controlled, and the thyroid tumor drastically reduced, and tracheal compression relieved. She continued anlotinib treatment for the following two months, but died one month later because the treatment stopped owing to financial reasons. All her sons underwent total thyroidectomy with lymph node dissection.ConclusionsAlthough NGS has been reported to assist in diagnosis of the origin of some tumors, this is the first evidence of NGS for the determination of the origin of thyroid tumors. To our knowledge, this is the first time that a combination of multiple mutations has been used to help determine the origin of a tumor, compared with the previous single mutant gene. Moreover, this is the first evidence on the use of anlotinib for treatment of UTC with distant metastasis. Besides, all three sons of the patient had thyroid carcinoma in subsequent examinations, indicating high-risk for familial non-medullary thyroid cancer in UTC patients and necessity for performing thyroid ultrasound testing in other family members.