bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silhouetting the Cost-Time Front: Multi-objective Resource Optimization in Business Processes
Authors: López-Pintado Orlenys , Dumas Marlon , Yerokhin Maksym , Maggi Fabrizio Maria 
Published: August 2021

AbstractThe allocation of resources in a business process determines the trade-off between cycle time and resource cost. A higher resource utilization leads to lower cost and higher cycle time, while a lower resource utilization leads to higher cost and lower waiting time. In this setting, this paper presents a multi-objective optimization approach to compute a set of Pareto-optimal resource allocations for a given process concerning cost and cycle time. The approach heuristically searches through the space of possible resource allocations using a simulation model to evaluate each allocation. Given the high number of possible allocations, it is imperative to prune the search space. Accordingly, the approach incorporates a method that selectively perturbs a resource utilization to derive new candidates that are likely to Pareto-dominate the already explored ones. The perturbation method relies on two indicators: resource utilization and resource impact, the latter being the contribution of a resource to the cost or cycle time of the process. Additionally, the approach incorporates a ranking method to accelerate convergence by guiding the search towards the resource allocations closer to the current Pareto front. The perturbation and ranking methods are embedded into two search meta-heuristics, namely hill-climbing and tabu-search. Experiments show that the proposed approach explores fewer resource allocations to compute Pareto fronts comparable to those produced by a well-known genetic algorithm for multi-objective optimization, namely NSGA-II.
The timing and duration of depressive symptoms from adolescence to young adulthood and young adults’ NEET status: the role of educational attainment
Authors: Veldman Karin , Reijneveld Sijmen A. , Hviid Andersen Johan , Nøhr Winding Trine , Labriola Merete , Lund Thomas , Bültmann Ute 
Published: August 2021

Abstract
Purpose
Depressive symptoms are negatively associated with labour market outcomes but whether the timing and duration of depressive symptoms or educational attainment (EA) affect NEET (Neither in Employment, Education, nor Training) is unknown. Therefore, this study aims to examine the effects of timing and duration of depressive symptoms in adolescence and the moderating and mediating role of EA on NEET in young adulthood.

Methods
Data were used from 1512 participants in the Vestliv Study, a Danish prospective cohort study. Depressive symptoms were measured at age 14, 18 and 21. EA at age 21 and NEET at age 23 were derived from national registers. Logistic regression analyses and a 4-way decomposition approach were applied.

Results
Among boys, depressive symptoms at ages 14 and 21 increased the risk of NEET (OR 1.65, 95% CI 1.00–2.74 and OR 2.20, 95% CI 1.37–3.53). Among girls, this regarded depressive symptoms at ages 18 and 21 (OR 1.76, 95% CI 1.26–2.46 and OR 1.59, 95% CI 1.13–2.22). For the duration of depressive symptoms, among boys any depressive symptoms increased the risk of NEET. Among girls, only persistent depressive symptoms increased the risk of NEET. EA did not mediate or moderate the association between depressive symptoms and NEET.

Conclusion
The timing and duration of depressive symptoms in adolescence matter for the association with NEET in young adulthood, with a double burden for those with both depressive symptoms and low EA. The results emphasize the importance of support for those who experience depressive symptoms in the school-to-work transition.
Parametric analysis of turning HSLA steel under minimum quantity lubrication (MQL) and nanofluids-based minimum quantity lubrication (NF-MQL): a concept of one-step sustainable machining
Authors: Javid Hassan , Jahanzaib Mirza , Jawad Muhammad , Ali Muhammad Asad , Farooq Muhammad Umar , Pruncu Catalin I. , Hussain Salman 
Published: August 2021

AbstractThe requirement of cost-effective and ecological production systems is crucial in the competitive market. In this regard, the focus is shifted towards sustainable and cleaner machining processes. Besides the clean technologies, effective parametric control is required for machining materials (such as High Strength Low Alloy Steels) specifically designed for high strength applications having superior physio-chemical properties. Therefore, the machinability complexities require optimized solutions to reduce temperature elevation and tooling costs and improve machining of these materials. Complying to the market needs, this research examines the effectiveness of nanofluid on tool life, wear mechanisms, surface roughness (Ra), surface morphology, and material removal rate (MRR) in turning of 30CrMnSiA (HSLA) using minimum quantity lubrication (MQL) and SiO2-H2O nanofluids (NF-MQL). A systematic investigation based on physical phenomena involved is carried out considering four process parameters (cutting speed (VC), feed rate (Fr), depth of cut (DOC), and mode of lubrication for machining. Fr is found as the vital parameter for surface roughness while MRR is highly influenced by DOC regardless of lubrication approach. One-step sustainability technique is applied, in which process variables used for roughing conditions are analogous to attain surface comparable to finished machining without compromising process efficiency and demonstrate its feasibility through optimal settings under NF-MQL. Multi-response optimization proved the NF-MQL machining condition as the best alternative which result in 28.34% and 5.09% improvements for surface roughness and MRR, respectively. Moreover, the use of SiO2 is recommended over MQL due to lower energy consumption, low tool wear, and better surface integrity, sustainable liquid, and related costs.
Potentiation of cognitive enhancer effects of Alzheimer’s disease medication memantine by alpha7 nicotinic acetylcholine receptor agonist PHA-543613 in the Morris water maze task
Authors: Bruszt Nóra , Bali Zsolt Kristóf , Tadepalli Sai Ambika , Nagy Lili Veronika , Hernádi István 
Published: August 2021

Abstract
Rationale
There are controversial pieces of evidence whether combination therapies using memantine and cholinesterase inhibitors are beneficial over their monotreatments. However, results of preclinical studies are promising when memantine is combined with agonists and allosteric modulators of the alpha7 nicotinic acetylcholine receptor (nAChR).

Objectives
Here, we tested the hypothesis that cognitive enhancer effects of memantine can be potentiated through modulating alpha7 nAChRs in a scopolamine-induced amnesia model.

Methods
Monotreatments, as well as co-administrations of selective alpha7 nicotinic acetylcholine receptor agonist PHA-543613 and memantine were tested in the Morris water maze task in rats. The efficacy of the co-administration treatment was observed on different domains of spatial episodic memory.

Results
Low dose of memantine (0.1 mg/kg) and PHA-543613 (0.3 mg/kg) successfully reversed scopolamine-induced short-term memory deficits both in monotreatments and in co-administration. When recall of information from long-term memory was tested, pharmacological effects caused by co-administration of subeffective doses of memantine and PHA-543613 exceeded that of their monotreatments.

Conclusion
Our results further support the evidence of beneficial interactions between memantine and alpha7 nAChR ligands and suggest a prominent role of alpha7 nAChRs in the procognitive effects of memantine.
Phylosymbiotic Structures of the Microbiota in Mollitrichosiphum tenuicorpus (Hemiptera: Aphididae: Greenideinae)
Authors: Qin Man , Jiang Liyun , Kholmatov Bakhtiyor R. , Qiao Gexia , Chen Jing 
Published: August 2021

AbstractAphids harbor an array of symbionts that provide hosts with ecological benefits. Microbial community assembly generally varies with respect to aphid species, geography, and host plants. However, the influence of host genetics and ecological factors on shaping intraspecific microbial community structures has not been fully understood. In the present study, using Illumina sequencing of the V3 − V4 hypervariable region of the 16S rRNA gene, we characterized the microbial compositions associated with Mollitrichosiphum tenuicorpus from different regions and plants in China. The primary symbiont Buchnera aphidicola and the secondary symbiont Arsenophonus dominated the microbial flora in M. tenuicorpus. Ordination analyses and statistical tests suggested that geography and aphid genetics primarily contributed to the variation in the microbiota of M. tenuicorpus. We further confirmed the combined effect of aphid genetics and geography on shaping the structures of symbiont and secondary symbiont communities. Moreover, the significant correlation between aphid genetic divergence and symbiont community dissimilarity provides evidence for intraspecific phylosymbiosis in natural systems. Our study helped to elucidate the eco-evolutionary relationship between symbiont communities and aphids within one given species.
KATP channels and NO dilate redundantly intramuscular arterioles during electrical stimulation of the skeletal muscle in mice
Authors: Schemke Simon , de Wit Cor 
Published: August 2021

AbstractFunctional hyperemia is fundamental to provide enhanced oxygen delivery during exercise in skeletal muscle. Different mechanisms are suggested to contribute, mediators from skeletal muscle, transmitter spillover from the neuromuscular synapse as well as endothelium-related dilators. We hypothesized that redundant mechanisms that invoke adenosine, endothelial autacoids, and KATP channels mediate the dilation of intramuscular arterioles in mice. Arterioles (maximal diameter: 20–42 µm, n = 65) were studied in the cremaster by intravital microscopy during electrical stimulation of the motor nerve to induce twitch or tetanic skeletal muscle contractions (10 or 100 Hz). Stimulation for 1–60 s dilated arterioles rapidly up to 65% of dilator capacity. Blockade of nicotinergic receptors blocked muscle contraction and arteriolar dilation. Exclusive blockade of adenosine receptors (1,3-dipropyl-8-(p-sulfophenyl)xanthine) or of NO and prostaglandins (nitro-L-arginine and indomethacin, LN + Indo) exerted only a minor attenuation. Combination of these blockers, however, reduced the dilation by roughly one-third during longer stimulation periods (> 1 s at 100 Hz). Blockade of KATP channels (glibenclamide) which strongly reduced adenosine-induced dilation reduced responses upon electrical stimulation only moderately. The attenuation was strongly enhanced if glibenclamide was combined with LN + Indo and even observed during brief stimulation. LN was more efficient than indomethacin to abrogate dilations if combined with glibenclamide. Arteriolar dilations induced by electrical stimulation of motor nerves require muscular contractions and are not elicited by acetylcholine spillover from neuromuscular synapses. The dilations are mediated by redundant mechanisms, mainly activation of KATP channels and release of NO. The contribution of K+ channels and hyperpolarization sets the stage for ascending dilations that are crucial for a coordinated response in the network.
The loci of Stroop effects: a critical review of methods and evidence for levels of processing contributing to color-word Stroop effects and the implications for the loci of attentional selection
Authors: Parris Benjamin A. , Hasshim Nabil , Wadsley Michael , Augustinova Maria , Ferrand Ludovic 
Published: August 2021

AbstractDespite instructions to ignore the irrelevant word in the Stroop task, it robustly influences the time it takes to identify the color, leading to performance decrements (interference) or enhancements (facilitation). The present review addresses two questions: (1) What levels of processing contribute to Stroop effects; and (2) Where does attentional selection occur? The methods that are used in the Stroop literature to measure the candidate varieties of interference and facilitation are critically evaluated and the processing levels that contribute to Stroop effects are discussed. It is concluded that the literature does not provide clear evidence for a distinction between conflicting and facilitating representations at phonological, semantic and response levels (together referred to as informational conflict), because the methods do not currently permit their isolated measurement. In contrast, it is argued that the evidence for task conflict as being distinct from informational conflict is strong and, thus, that there are at least two loci of attentional selection in the Stroop task. Evidence suggests that task conflict occurs earlier, has a different developmental trajectory and is independently controlled which supports the notion of a separate mechanism of attentional selection. The modifying effects of response modes and evidence for Stroop effects at the level of response execution are also discussed. It is argued that multiple studies claiming to have distinguished response and semantic conflict have not done so unambiguously and that models of Stroop task performance need to be modified to more effectively account for the loci of Stroop effects.
Experience-dependent reshaping of body gender perception
Authors: D’Argenio Giulia , Finisguerra Alessandra , Urgesi Cosimo 
Published: August 2021

AbstractProtracted exposure to specific stimuli causes biased visual aftereffects at both low- and high-level dimensions of a stimulus. Recently, it has been proposed that alterations of these aftereffects could play a role in body misperceptions. However, since previous studies have mainly addressed manipulations of body size, the relative contribution of low-level retinotopic and/or high-level object-based mechanisms is yet to be understood. In three experiments, we investigated visual aftereffects for body-gender perception, testing for the tuning of visual aftereffects across different characters and orientation. We found that exposure to a distinctively female (or male) body makes androgynous bodies appear as more masculine (or feminine) and that these aftereffects were not specific for the individual characteristics of the adapting body (Exp.1). Furthermore, exposure to only upright bodies (Exp.2) biased the perception of upright, but not of inverted bodies, while exposure to both upright and inverted bodies (Exp.3) biased perception for both. Finally, participants’ sensitivity to body aftereffects was lower in individuals with greater communication deficits and deeper internalization of a male gender role. Overall, our data reveals the orientation-, but not identity-tuning of body-gender aftereffects and points to the association between alterations of the malleability of body gender perception and social deficits.
3D holotomographic monitoring of Ca++ dynamics during ionophore-induced Neospora caninum tachyzoite egress from primary bovine host endothelial cells
Authors: Larrazabal C. , Hermosilla C. , Taubert A. , Conejeros I. 
Published: August 2021

AbstractNeospora caninum represents an obligate intracellular parasite that belongs to the phylum Apicomplexa and is a major abortive agent in bovines. During merogony, N. caninum tachyzoites invade and proliferate in host cells in vivo, including endothelial cells of lymphatic and blood vessels. The egress at the end of the lytic cycle is tightly regulated in apicomplexans. Evidence in Toxoplasma gondii shows that Ca++ signalling governs tachyzoite egress. Much less is known on egress mechanisms of N. caninum. Here, we show, using 3D live cell holotomographic microscopy in fluo-4 AM-loaded N. caninum-infected BUVEC, that treatments with the calcium ionophore A23187 at 24- and 42-h post-infection (h p. i.) induced a fast and sustained increase in Ca++ signals in parallel to tachyzoite egress. A23187 treatments exclusively triggered tachyzoite release at 42-h p. i. but failed to do so at 24-h p. i. indicating a role for meront maturation in calcium-induced tachyzoite egress. Overall, we show that live cell 3D holotomographic analysis in combination with epifluorescence is a suitable tool to study calcium dynamics related to coccidian egress or other important cell functions.
Impurity Profiling of Baclofen Using Gradient HPLC–UV Method
Authors: Leistner Adrian , Holzgrabe Ulrike 
Published: August 2021

AbstractThe GABABreceptor agonist baclofen is a medication commonly used for the treatment of muscle spasticity. It is an amino acid and related to the neurotransmitter GABA. In this study, we developed a new, gradient high-performance liquid chromatography (HPLC) method for the impurity assessment of baclofen, which is appropriate for pharmacopoeial purposes. Since the impurities related to the synthesis pathway are acids, zwitterionic, or neutral, the method development is challenging. However, the separation of all components was achieved on a C18 stationary phase using a water–acetonitrile–trifluoroacetic acid gradient. A limit of detection (LOD) of at least 0.02% was registered for all specified impurities. Additionally, CAD detection was performed to detect potential impurities lacking off a chromophore. The baclofen batches analyzed are far more pure than expected. All impurities were found below the specification limit, and thus, they can be regarded as unspecified. Moreover, the required runtime could be significantly reduced compared to the current USP or Ph. Eur. method.
Genetic diversity and relatedness in aquaculture and marina populations of the invasive tunicate Didemnum vexillum in the British Isles
Authors: Prentice M. B. , Vye S. R. , Jenkins S. R. , Shaw P. W. , Ironside J. E. 
Published: August 2021

AbstractIntroductions of invasive, non-native species in the marine environment are increasing as human activity within coastal areas rises. Genetic datasets are useful tools to identify source populations, track routes of invasions, and illuminate the role of genetic variation in the establishment and subsequent spread of novel introductions. Here, a microsatellite dataset is used to estimate the genetic diversity and population structure of 7 introduced Didemnum vexillum populations in Britain and Ireland, 4 of which are associated with aquaculture and 3 with marinas. Genetic differentiation observed between these populations indicates human-mediated transport as the main mechanism underlying the population structure of D. vexillum in Britain and Ireland. In addition to elucidating patterns of population structure we found that aquaculture sites showed significantly higher genetic diversity (measured as allelic richness) in comparison to the marina sites. We discuss these findings in relation to the history of each invasion, the complex life history of D. vexillum, and available evidence of the relative invasiveness of these populations. Our results show numerous interesting patterns which highlight further research avenues to elucidate the complex factors underlying the global spread of this successful invader.
Divergent, plausible, and relevant climate futures for near- and long-term resource planning
Authors: Lawrence David J. , Runyon Amber N. , Gross John E. , Schuurman Gregor W. , Miller Brian W. 
Published: August 2021

AbstractScenario planning has emerged as a widely used planning process for resource management in situations of consequential, irreducible uncertainty. Because it explicitly incorporates uncertainty, scenario planning is regularly employed in climate change adaptation. An early and essential step in developing scenarios is identifying “climate futures”—descriptions of the physical attributes of plausible future climates that could occur at a specific place and time. Divergent climate futures that describe the broadest possible range of plausible conditions support information needs of decision makers, including understanding the spectrum of potential resource responses to climate change, developing strategies robust to that range, avoiding highly consequential surprises, and averting maladaptation. Here, we discuss three approaches for generating climate futures: a Representative Concentration Pathway (RCP)-ensemble, a quadrant-average, and an individual-projection approach. All are designed to capture relevant uncertainty, but they differ in utility for different applications, complexity, and effort required to implement. Using an application from Big Bend National Park as an example of numerous similar efforts to develop climate futures for National Park Service applications over the past decade, we compare these approaches, focusing on their ability to capture among-projection divergence during early-, mid-, and late-twenty-first century periods to align with near-, mid-, and long-term planning efforts. The quadrant-average approach and especially the individual-projection approach captured a broader range of plausible future conditions than the RCP-ensemble approach, particularly in the near term. Therefore, the individual-projection approach supports decision makers seeking to understand the broadest potential characterization of future conditions. We discuss tradeoffs associated with different climate future approaches and highlight suitable applications.
Hydrodynamical Model for Charge Transport in Graphene Nanoribbons
Authors: Camiola Vito Dario , Nastasi Giovanni 
Published: August 2021

AbstractWe present a hydrodynamical model for graphene nanoribbons that takes into account the electron collisions with the lattice and with the edge of the ribbon. Moreover the bandgap due to the low dimension of the ribbon is considered. The simulation shows that the model describes qualitatively the macroscopic behavior of the charges and the results are comparable with that ones obtained by solving numerically the Boltzmann equation but with a remarkable reduction of the computational time.
Engagement in Prescription Opioid Tapering Research: the EMPOWER Study and a Coproduction Model of Success
Authors: Mardian Aram , Perez Luzmercy , Pun Ting , Cheung Matthias , Porter Joel , De Bruyne Korina , Kao Ming-Chih , Flood Pamela , Moore Nathaniel , Colloca Luana , Cramer Eric , Ashton-James Claire E. , Lorig Kate , Mackey Sean C. , Darnall Beth D. 
Published: August 2021

AbstractPatients with chronic pain experience stigma within the healthcare system. This stigma is compounded for those taking long-term prescription opioids. Often, public messaging and organizational policies have telegraphed that opioid treatment is a problem to be solved by focusing only on medication reduction efforts. Lack of data has contributed to misperceptions and poor opioid policies. In part, data collection remains poor because patients feel fractured from systems of care and are often not interested in engaging with opioid reduction mandates and research. Similarly, clinicians may fail to engage with opioid stewardship and research due to complexities that exceed their training or capacities. The EMPOWER study applies a coproduction model that engages researchers, patients, clinicians, managers, and other health system users. Key stakeholders shaped the design of the study to best ensure acceptability and engagement of the “end users”—patients who enroll in the study and the clinicians who implement the opioid tapers. Targeting the needs of any stakeholder group in isolation is suboptimal. Accordingly, we detail the EMPOWER patient-centered opioid tapering clinical research framework and specific strategies to address stakeholder concerns. We also discuss how this framework may be applied to enhance engagement in healthcare research broadly.