bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Investigation Into the Mechanism of Li Chong Pill for Treating Endometriosis Based on Network Pharmacology and Molecular Docking Verification
Authors: Liu Shao-Xuan , Han Feng-Juan , Zhang Chun-Lan , Shen Ying , Li Jia , Fu Yang , Guo Ying 
Published: March 2021

Abstract
Background and objective: Li Chong Wan (Li Chong pill, LCP) origin from Yi Xue Zhong Zhong Can Xi Lu, (Records of Chinese Medicine with Reference to Western Medicine), widely used in the treatment of endometriosis (EM) in China. The purpose of this study is to investigate the intrinsic mechanisms of LCP against EM and to provide new evidence for its clinical application.Methods: Chemical compounds of LCP were screened and evaluated via retrieving public databases and literature. We also acquired their putative targets and obtained EM-related targets. The above-mentioned data were visualized as a component-target network. In addition, we use Cytoscape3.8.0 to build a protein-protein interaction network and identified hub genes and key active ingredients. Furthermore, through GO and KEGG pathway analyses, which were actualized by R3.6.1 (based on clusterProfiler, org.Hs.eg.Db, and pathview package), we obtained effective signaling pathways and biological functions. Molecular docking was used to verify binding activity between compounds and the key targets at last.Results: Finally, a total of 122 possible active targets and 47 components were screened. Identify the core network and screen out 10 main targets; GO and KEGG enrichment analysis revealed that LCP may have functions of anti-inflammatory, anti-angiogenesis, inhibition of cell proliferation, regulation of hormone secretion, etc. The effect of LCP on EM might be achieved by PI3K/Akt signaling pathway, HIF-1 signaling pathway, estrogen signaling pathway, and VEGF signaling pathway, etc. Finally, molecular docking results demonstrated that 14 components were exhibited good binding property to the key targets of EM.Conclusion: This research ocularly demonstrated the multi-component, multi-target, and multi-channel pharmacological effects for LCP in the treatments of EM and provides evidence for further clinical research and verification of the mechanism.
Bifurcation Analysis of a Railway Wheelset With Nonlinear Wheel-rail Contact
Authors: Guo Jinying , Shi Huailong , Luo Ren , Zeng Jing 
Published: March 2021

Abstract
Stability is a key factor for the operation safety of railway vehicles, while current work employs linearized and simplified wheel/rail contact to study the bifurcation mechanism and assess the stability. To study the stability and bifurcation characters under real nonlinear wheel/rail contact, a fully parameterized nonlinear railway vehicle wheelset model is built. In modeling, the geometry nonlinearities of wheel and rail profiles come from field measurements, including the rolling radius, contact angle, and curvatures, etc. Firstly, four flange force models and their effects on the stability bifurcations are compared. It shows that an exponent fitting is more proper than a quintic polynomial one to simulate the flange, and works well without changing the Hopf bifurcation type. Then the effects of each term of the nonlinear geometry of wheel/rail contact on the Hopf bifurcation and Limit Circle bifurcation are discussed. Both the linear term and nonlinear term of rolling radius have a significant influence on Hopf bifurcation and Limit Point of Circle (LPC) bifurcation. The linear critical speed (Hopf bifurcation point) and the nonlinear critical speed (LPC bifurcation point) changes times while within the calculated range of the linear term of the rolling radius. Its nonlinear term changes the bifurcation type and the nonlinear critical speed almost by half. The linear term of contact angle, the radius of curvature of wheel, and rail profile should be taken into consideration since they can change both the bifurcation point and type, while the cubic term can be ignored. Furtherly, the field measured wheel profiles for several running mileages are employed to examine the real geometry nonlinearities and the according Hopf bifurcation behavior. The result shows that a larger suspension stiffness would increase the running stability under wheel wear.
Thiacloprid + Deltamethrin Against the Cotton Aphid and the Parasitoid Wasp Aphidius Colemani: From Lethal to Sublethal Population Effects
Authors: Majidpour Marzieh , Maroofpour Nariman , Ghane-Jahromi Mojtaba , Guedes Raul Narciso C. 
Published: March 2021

Abstract
The side effects of insecticides on non-target species are important to secure the intended effectiveness of pest management programs. The cotton aphid Aphis gossypii is a frequent problem in industrial greenhouse cultivation, and insecticide and parasitoids are often used for crop protection. Among insecticides, mixtures are playing increasing roles in pest management in greenhouse production system, as well as parasitoid use. The insecticide mixture thiacloprid + deltamethrin and the parasitoid wasp Aphidius colemani are the main agents used against the cotton aphid and are the focus of this study. Here, we report the effects of the thiacloprid + deltamethrin on A. gossypii and Aphidius colemani. The sublethal concentrations 2.80 mg ai/l (LC10) and 7.28 mg ai/l (LC30) compromised the demographic parameters of the aphid progeny and increased the development time at all juvenile stages. In addition, fecundity, longevity and population parameters (r, R0, and T) were significantly impaired by thiacloprid + deltamethrin, at both concentrations. The median lethal time estimate (LT50) for Aphidius colemani was 18.73 h; the parasitoid mortality was significant up to 24 h after application, but decreased afterwards. Regardless, the parasitoid life table parameters were also compromised by insecticide exposure, similarly to the parasitoid population growth and parasitism efficacy. These results demonstrate the effect of the insecticide mixture against A. gossypii, as well as the increased risk of its adverse impacts on the parasitoid Aphidius colemani, which signals against their simultaneous application to control this pest species.
Effect of In Situ Grown BNNTs and Preparation Temperature on Mechanical Behavior of SiC/SiC Minicomposites
Authors: Xu Shenwei , Pi Huilong , Wu Pengfei , Shi Yuan , Yang Haitang , Li Longbiao , Huang Xiaozhong 
Published: March 2021

Abstract
In this paper, effect of in situ grown boron nitride nanotubes (BNNTs) and preparation temperature on mechanical behavior of PIP (Precursor Infiltration and Pyrolysis) SiC/SiC minicomposites under monotonic and compliance tensile is investigated. In situ BNNTs are grown on the surface of SiC fibers using ball milling – annealing process. Composite elastic modulus, tensile strength, fracture strain, tangent modulus, and loading/unloading inverse tangent modulus (ITM) are obtained and adopted to characterize the mechanical properties of the composites. Microstructures of in situ grown BNNTs and tensile fracture surfaces are observed under scanning electronic microscopic (SEM). For SiC/SiC minicomposites with BNNTs, the elastic modulus, tensile strength, and fracture strain are all lower than those of SiC/SiC minicomposites without BNNTs, mainly due to high preparation temperature and the oxidation of the PyC interphase during the annealing process. Tensile stress-strain curves of SiC/SiC minicomposites with and without BNNTs are predicted using the developed micromechanical constitutive model. The predicted results agreed with experimental data. This work will provide guidance for predicting the service life of SiCf/SiC composite materials and may enable these materials to become a backbone for thermal structure systems in aerospace applications.
Formation of BaF2 Microcrystals as Superhydrophobic Materials via a Hydrothermal Method
Authors: Ma Jinxiu , Ou Gaoyu , Li Taohai , Li Feng 
Published: March 2021

Abstract
Controllable BaF2 microcrystals with super-hydrophobic property have been successfully synthesized via a facile hydrothermal process. XRD, SEM and CA are used to study the structure, morphology and the hydrophobic properties of the BaF2 materials. The effects of reaction time, surfactants and pH are also detailed investigated in order to get a series of accurate reaction conditions for the preparation of BaF2 material. The results show that uniform BaF2 tetragonal phase structure was fabricated when the reaction temperature was controlled at 180 oC for 24 h. In addition, the BaF2 materials showed excellent super-hydrophobic properties. The results about the influence of time and substrates exhibit that the sample can maintain the stable super-hydrophobic property for over 10 days. As a promising super hydrophobic materials, the studies of BaF2 reported in this paper is quite practical and it has a certain guiding meaning for the future study about super hydrophobic materials.
Assessment of rotary drum and aerated in-vessel for composting of garden waste
Authors: Mishra Sandeep , Yadav Kunwar D 
Published: March 2021

Abstract
For in-vessel composting of garden waste, the selection of reactor is an important factor for efficient degradation. The present study evaluates working performance of rotary drum reactor (RDR) and aerated in-vessel (AIV) for composting of garden waste. 100 kg garden waste was mixed with 10 kg cow-dung slurry and 5 kg compost and feed into both the reactors for 45 days composting period. The reactors vary in their system configuration, shape and orientation, blade design, rate of aeration, odour control, leachate production and energy requirements. Rotary drum was rotated daily six times in clockwise and anti-clockwise direction and AIV was rotated daily for 3–5 minutes using motor. Rise in temperature started within 24 hours of composting and reached 65°C and 59°C on second day itself and thermophilic phase continued for 7 and 5 days for RDR and AIV respectively. Moisture content reduction after composting period was 15.25 and 18.45 %, C/N ratio was 16.14 and 13.33, TVS reduction was 23.74 and 29.78 % and CO2 evolution rate was 6.18 and 4.14 mg/g VS/day in RDR and AIV respectively. Reduction of hemicellulose, cellulose, and lignin was more in AIV. The percentage reduction of acid insoluble lignin was 36.10 and 29.01 % and the percentage reduction of acid soluble lignin was 48.85 and 43.3% in in AIV and RDR respectively after 45 days. AIV gave better performance for composting of garden waste.
Extracellular Pyomelanin Pigment Production, Purification and Characterization with Streptomyces griseus MPPS2
Authors: BAYRAM Sinan 
Published: March 2021

Abstract
Melanins are natural pigments widely distributed in nature from bacteria to humans. These complex, negatively charged, amorphous, high molecular mass natural biopolymers have many different bioactive properties such as antimicrobial, antiviral, antioxidant, liver protective effects etc. In this study, some chemical and physical properties of the extracellular pyomelanin pigment purified from Streptomyces griseus MPPS2 was investigated via XRD (X-Ray diffraction), FT-IR (Fourier transform infra-red) and 1H NMR (Nuclear magnetic resonance). Additionally, the melanin pigment-producing Streptomyces griseus MPPS2 strain was identified at species level by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/TOF MS) and 16S rDNA sequence analysis. 16S rDNA sequence analysis result was deposited in NCBI under accession number MT825616.
Hydrolyzed FB1 (aminopentol) detection on urine of HPV positive Mexican women: A preliminary study
Authors: Ramírez-Cisneros M. Ángeles , Rivera Vladimir , Rios Maria Yolanda , Vargas-De-León Cruz , Dávila Sonia , Peralta Raúl 
Published: March 2021

Abstract
Human Papillomavirus (HPV) infection is the most common sexually transmitted disease in humans. About 200 HPV types have been described and classified into high and low oncogenic risk for its ability to transform the cell. Some main risk factors for HPV infection are multiple sexual partners, multiparity and immunosuppression. However, these factors can not completely explain the HPV prevalence in different world regions. Mexico has a high global burden, being important to determine other external biological factors implicated. The infection is mediated by surface receptors of basal stratum cells that bind to the viral capsid entering the cell by endocytosis. Some cell membrane components such as sphingolipids have a role in structure and membrane permeability. Besides, fumonisins are micotoxins structurally very similar to sphingolipids, fumonisin B1 (FB1) is the most abundant and most similar to some sphingolipids such ceramide. Fumonisins are produced by Fusarium fungus, widely distributed in maize, the main component of Mexican diet. Thus, it is possible that FB1 contamination be a factor to permeabilize the membrane expediting the HPV infection. In this preliminary study, we postulated that mechanism of HPV infection is mediated by contamination with FB1, hence, FB1 could be higher in women HPV positive. Urine samples from patients with HPV infection and healthy woman were analyzed by UPLC-MS, hydrolyzed FB1 was found only in the infected women, in contrast, in HPV negative women was not detected. Additional studies are needed to support the hypothesis of contamination with FB1 as biological risk factor for HPV infection.
Frozen Section Diagnosis: Accuracy and Errors; with Emphasis on Reasons for Discordance
Authors: Gidwani Roopam Kishore , Goswami Falguni Jay , Mehta Arpan , Shah Nirali V , Prajapati Shobhana Ashok , Shah Manisha M 
Published: March 2021

Background: Frozen section is a multistep process involving surgical resection, intraoperative preparation of slides and their microscopic examination. It is important to assess concordant, discordant and deferred diagnosis rates from intra-operative frozen section diagnosis with final diagnosis on paraffin section and to determine the reasons for discordance. An integral part of quality assurance in surgical pathology entails the correlation of intra-operative frozen section diagnosis with final diagnosis on permanent section.
Methods: A retrospective analysis of 117 cases of frozen section biopsy was carried out which were reported in the Histopathology department between July 2007 to June 2012. The correlation between the frozen section diagnosis with final histological diagnosis was performed in order to check the accuracy of the technique. The number and type of discrepancies were compared, causes for the discrepancies were analyzed in order to decrease the avoidable errors and improve on the frozen section diagnoses.
Results: The overall accuracy of frozen section diagnoses over 5years was 90.60% with false positive rate of 0.85%, false negative rate of 6.84% and 1.71% of deferred diagnosis. Sensitivity was 87.69% and Specificity was 98%. The discrepancies were mainly due to the interpretation error, sampling error and technical artefacts.
Conclusions: Gross inspection, sampling by pathologist, frozen section complemented with cytological and histological review and cooperation between consultants can avoid certain limitations and provide rapid, reliable, cost effective information necessary for optimum patient care.
Metastatic Breast Carcinoma to The Uterine Cervix - An Unusual Presentation
Authors: Varghese Maymol P , Raju Sreeja , MC Savithri , Augustine Joy , Varghese Mathew 
Published: March 2021

Uterine cervix involvement as a site of metastasis from a distant primary tumor is rare. Metastasis from breast carcinoma in a patient undergoing treatment is even rarer. The present case report is of a 47-year-old lady with history of carcinoma breast on treatment and who was referred to our hospital with complaints of lower limb oedema, low backache and postmenopausal whitish discharge per vaginum. Per vaginal examination revealed a lesion arising in the cervix extending up to the anterior vaginal wall suggestive of a clinical diagnosis of carcinoma cervix. Subsequent biopsy from the lesion showed malignant cells arranged in Indian file pattern and focal alveolar pattern, hinting at a diagnosis of Invasive lobular carcinoma metastasis. The neoplasm was positive for ER, PR and GATA-3 and negative for Her2/neu and E-cadherin confirming our diagnosis. Although rare, the poor outcome in such patients makes it even more important for its identification and the need for them to undergo careful routine gynecologic examination.
Machine Learning for Mental Health in Social Media: Bibliometric Study
Authors: Kim Jina , Lee Daeun , Park Eunil 
Published: March 2021

Background
Social media platforms provide an easily accessible and time-saving communication approach for individuals with mental disorders compared to face-to-face meetings with medical providers. Recently, machine learning (ML)-based mental health exploration using large-scale social media data has attracted significant attention.

Objective
We aimed to provide a bibliometric analysis and discussion on research trends of ML for mental health in social media.

Methods
Publications addressing social media and ML in the field of mental health were retrieved from the Scopus and Web of Science databases. We analyzed the publication distribution to measure productivity on sources, countries, institutions, authors, and research subjects, and visualized the trends in this field using a keyword co-occurrence network. The research methodologies of previous studies with high citations are also thoroughly described.

Results
We obtained a total of 565 relevant papers published from 2015 to 2020. In the last 5 years, the number of publications has demonstrated continuous growth with Lecture Notes in Computer Science and Journal of Medical Internet Research as the two most productive sources based on Scopus and Web of Science records. In addition, notable methodological approaches with data resources presented in high-ranking publications were investigated.

Conclusions
The results of this study highlight continuous growth in this research area. Moreover, we retrieved three main discussion points from a comprehensive overview of highly cited publications that provide new in-depth directions for both researchers and practitioners.
Changer sa façon de changer – Grandes orientations du CSP Jura pour les décennies à venir
Authors: De Montmollin Gabriel 
Published: March 2021

In seinem Beitrag « Changer sa façon de changer – Grandes orientations du CSP Jura pour les décennies à venir » ergründet Gabriel de Montmollin die zukünftigen Arbeitsschwerpunkte für die CSP in der Romandie.De Montmollin geht davon aus, dass die Gesellschaft zukünftig mit folgenden sozialen Herausforderungen konfrontiert sein wird: Die ökologischen Entwicklungen, die Digitalisierung der Arbeitswelt, die Migrationsströme sowie die demografische Alterung. Diesen Herausforderungen will de Montmollin begegnen, indem er sie in unterschiedlicher Weise aufeinander bezieht und so neue Stärken und Synergien schafft:Zu den Herausforderungen «Migration» und «demografische Alterung» führt de Montmollin die Leserin / den Leser auf den Wohnungsmarkt der Stadt Genf, der bekanntlich kaum Leerbestände aufweist und in welchem hohe Mieten zu bezahlen sind – junge Menschen sowie Migrantinnen und Migranten finden kaum mehr (bezahlbare) Unterkunft. Zugleich wohnen ältere, alleinstehende Menschen – zuweilen in einsamen Lebenssituationen – alleine in grösseren Wohnungen oder Häusern. Er plädiert dafür, aus mit innovativen Wohnprojekten den beidseitigen Problemlagen (Wohnungsnot einerseits und Einsamkeit andererseits) zu begegnen.Den Herausforderungen «ökologische Entwicklung» und «Digitalisierung der Arbeitswelt» will de Montmollin mit neuen protestantischen Impulsen in der Arbeitswelt begegnen: Wenn mehr und mehr Roboter den Menschen Arbeitsplätze wegnähmen, so müssten diese freiwerdenden Ressourcen eingesetzt werden für Anstrengungen im Bereich des ökologischen Wirtschaftens: die CSP sollten sich zu «grünen» CSP weiterentwickeln.Schliesslich spricht sich de Montmollin – analog den Modellen von Rotem Kreuz und Caritas – dafür aus, dass sich auch die CSP in eine nationale und internationale Struktur integrieren und dem Hilfswerk der evangelischen Kirchen der Schweiz (HEKS) fusionieren.
CAS Diakonie-Entwicklung - ein Weiterbildungsangebot zur Stärkung einer diakonischen Kirche
Authors: Scherzinger Gregor 
Published: March 2021

Gregor Scherzinger schickt in seinem Beitrag «CAS Diakonie-Entwicklung – ein Weiterbildungsangebot zur Stärkung der diakonischen Kirche» eine diakoniewissenschaftliche Reflexion voraus, in welcher er vom «Relevanzverlust kirchlicher Verkündigung» ausgeht und postuliert, dass insbesondere das diakonische Wirken geeignet und in der Lage ist, «kirchliche Glaubwürdigkeit in einer säkularen Gesellschaft» zu bewahren und durch die Öffnung der Kirche zu dem Menschen «dem kirchlichen Leben Impulse zu ermöglichen». D.h. durch die «zentrifugale Bewegung» soll die Kirche als Institution neu «mit Menschen von draussen in der Welt in Berührung kommen» und darin das Credo «eines menschenwilligen und menschenfreundlichen Gottes in die radikale Erfahrung der Weltlichkeit der Welt» konkretisieren. Zugleich holt die Diakonie damit «ihrem Anspruch nach die Welt in die Kirche hinein, um Kirche als Kirche in der heutigen Welt neu zu verstehen, aber auch um gleichzeitig die Welt zu einem besseren Ort für die Menschen zu verwandeln».
Diese Orientierung bietet die «theologische und diakonische Selbstvergewisserung» des Weiterbildungszertifikats CAS Diakonie-Entwicklung, das Gregor Scherzinger mit weiteren Beteiligten entwickelt hat und dessen Ausbildungsgang im Frühling 2019 zum ersten Mal gestartet ist.
In der Überzeugung, dass «Kirche und Theologie kein eigenes human- oder sozialwissenschaftliches Sonderwissen über die Zusammenhänge und Gesetzlichkeiten von Gesellschaft und Mensch» verfügt, kommt im Weiterbildungszertifikat der Aneignung von entsprechenden Fachkompetenzen, insbesondere in der Gemeinwesenarbeit, grosse Bedeutung zu.
In der Absicht, dass die kirchliche Diakonie «von der Anbieterin zur Begleiterin» wird, setzt die Weiterbildung einen Schwerpunkt in der «Gestaltung von Partizipationsprozessen im Rahmen von Freiwilligenmanagement, Projektplanung und Öffentlichkeitsarbeit» und will damit Räume öffnen, in denen «Menschen sich selbst aktiv beteiligen». Durch solche Partizipationsprozesse soll der Anspruch eingelöst werden, Kirche nahe bei den Menschen zu halten.