bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRIM11 suppresses ferritinophagy and gemcitabine sensitivity through UBE2N/TAX1BP1 signaling in pancreatic ductal adenocarcinoma
Authors: Shang Mingyi , Weng Li , Xu Guifang , Wu Shaoqiu , Liu Bingyan , Yin Xiang , Mao Aiwu , Zou Xiaoping , Wang Zhongmin 
Published: February 2021

AbstractGemcitabine is first‐line chemotherapy for pancreatic cancer, however, the development of resistance limits its effectiveness. The tripartite motif‐containing 11 (TRIM11) protein plays crucial roles in tumor development and undergoes auto‐polyubiquitination to promote interactions in selective autophagy. Therefore, Understanding whether TRIM11 is involved in ferritinophagy and gemcitabine resistance in pancreatic cancer is critical in developing pancreatic cancer therapeutics. TRIM11 expression was validated by Western blot analysis, real‐time polymease chain reaction, and immunohistochemical staining. 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide and Colony formation assays were performed to investigate pancreatic ductal adenocarcinomas (PDAC) cell viability. Mouse xenograft model of PDAC cells was established to verify the role of TRIM11 in vivo. Coimmunoprecipitation was used to identify the reciprocal regulation between TRIM11 and UBE2N. In this study, we found that TRIM11 expression were higher in PDAC cells and tissues. TRIM11 overexpression promotes PDAC cell proliferation in vitro and tumor growth in vivo. Decreased expression of TRIM11 in PDAC patients is associated with decreased UBE2N and increased TAX1BP1 expression. Coimmunoprecipitation established that TRIM11 interacts and colocalizes with UBE2N. Mechanistically, TRIM11 promoted gemcitabine resistance and suppressed ferritinophagy through UBE2N‐TAX1BP1 signaling. Our findings identify TRIM11 as a key regulator of TAX1BP1 signaling with a crucial role in ferritinophagy and gemcitabine resistance in PDAC.
Abdominal aortic aneurysm and virus infection: A potential causative role for cytomegalovirus infection?
Authors: Jabłońska Agnieszka , Zagrapan Branislav , Paradowska Edyta , Neumayer Christoph , Eilenberg Wolf , Brostjan Christine , Klinger Markus , Nanobachvili Josif , Huk Ihor 
Published: February 2021

AbstractAn abdominal aortic aneurysm (AAA) is a multifactorial disease with a variety of genetic and environmental risk factors, but the exact mechanism of AAA formation and progression is still not well understood. The present study investigated the frequency of cytomegalovirus (CMV), Epstein‐Barr virus (EBV), and papillomavirus types 6 and 11 (HPV6 and HPV11), their impact on clinical manifestations of cardiovascular diseases, and their possible association with inflammation in patients with AAA and healthy volunteers. Genotyping of CMV UL75, EBV LMP‐1, and HPV6, and HPV11 E6 was performed by polymerase chain reaction (PCR), while the viral DNA loads were measured by quantitative real‐time PCR. Cytokine levels were determined by enzyme‐linked immunosorbent assays. The CMV UL75 was detected more frequently in the blood of patients with AAA than in the blood of healthy volunteers (32.7% vs. 6.3%, p < .0001). Neither EBV LMP‐1 nor HPV6 E6 was found in blood and aortic wall biopsies, while the HPV11 E6 was detected in 36.4% of AAA walls. The CMV infection in patients with AAA was associated with an increased risk of hypertension and coronary artery disease (OR, 9.057; 95% CI, 1.141–71.862; p = .037; and OR, 2.575; 95% CI, 1.002–6.615; p = .049, respectively). Additionally, CMV‐infected patients with AAA had higher tumor necrosis factor‐α levels compared with noninfected subjects (p = .017). Our findings suggest that CMV infection can stimulate local inflammation in the aorta but is not a direct cause of most abdominal aortic aneurysms.
Classical approach to off‐resonant Raman coherence with chirped femtosecond laser pulses
Authors: Marrocco Michele 
Published: February 2021

AbstractRaman coherence of electronically off‐resonant transitions provides a simple class of Raman techniques that, when realized with chirped femtosecond laser pulses, are commonly studied with reference to the methods of quantum mechanics. In this work, we show instead that the classical approach, when extended to chirp‐dependent laser fields, is equally effective in reproducing experimental results that are particularly sensitive to the chirp carried by the laser pulses. The extension is nothing but a follow‐up of the traditional model based on the driven damped harmonic oscillator, which is however known to work for transform‐limited femtosecond pulses. The demonstration starts with the comparison of the time‐dependent third‐order polarizations for the Liouville‐space wavepacket representation with the classical analog. The formal similarity between these nonlinear polarizations is further analyzed in the frequency domain to show an important difference related to the handling of the phase factor containing the carrier frequencies of the laser pulses. Finally, we simulate a couple of significant and acknowledged chirp‐dependent experimental measurements in the impulsive regime of stimulated Raman scattering.
Effects of grazing control on ecosystem recovery, biological productivity gains, and soil carbon sequestration in long‐term degraded loess farmlands in the Northern Negev, Israel
Authors: Leu Stefan , Ben‐Eli Michael , Mor‐Mussery Amir 
Published: February 2021

AbstractHigh rainfall variability in drylands complicates comparison in time of productivity and soil fertility, and their changes due to altered management. In order to determine the extent, kinetics, and mechanisms of soil and ecosystem recovery achievable in degraded loess plots in southern Israel, aboveground net primary production (ANPP) and soil quality in three fenced plots were analyzed between 2011 and 2017 for experimental confirmation of previously formulated hypotheses on the ecosystem recovery potential in this area. A degraded control plot [<20% biological productivity, marginal plant biodiversity, 50% reduced soil organic matter (SOM)] was analyzed in the same way to normalize annual growth rates in the protected plots. An abandoned ruminants' enclosure was chosen as a reference plot for maximum achievable values to estimate the duration to full ecosystem recovery. The protected loess areas displayed rapid full recovery of soil moisture measured at the end of the rainy season after 3 years already. Annual normalized ANPP increased 5‐fold within 6 years of protection to 3 Mg dry matter per hectare and year, or 60% of the locally achievable maximum ANPP. Herbaceous species numbers increased about 10‐fold in the protected plots as compared to the degraded control plot. Normalized soil carbon sequestration rates of ~5 Mg CO2eq ha−1 yr−1 were deduced from yearly normalized SOM changes. This methodology can be applied universally to determine the true biological production potentials of areas of unknown land degradation/rehabilitation state, and for assessing gains in ecosystem services achievable by restoration of degraded dry agroecosystems such as biodiversity, fodder production, and carbon sequestration.
Does consumer ethnocentrism impact international shopping? A theory of social class divide
Authors: Aljukhadar Muhammad , Boeuf Benjamin , Senecal Sylvain 
Published: February 2021

AbstractResearch on international shopping has the potential of elucidating collective issues such as the eminence of protectionist discourse. Concomitantly, the authors propose a Theory of Social Class Divide (SCD) that explains how the judgments of a consumer segment diverge from classical predictions. The theory received support in an international shopping context, showing that the behavior of lower‐class shoppers diverges from the prediction of consumer ethnocentrism theory. In the two studies, which comprised different methods (cross‐sectional and experimental), measures of social class (objective and subjective), and samples (US and Canadian), lower‐class consumers were notably less affected by their ethnocentrism than upper‐class consumers. Lower‐class consumers generally showed, regardless of their ethnocentrism, low attitudes, and shopping intentions toward foreign retailers. The results underline the ramifications of a widening divide in social class on international marketing, and have potential implications in germane fields such as political science.
Unshielded bent folded‐end dipole 9.4 T human head transceiver array decoupled using modified passive dipoles
Authors: Avdievich Nikolai I. , Solomakha Georgiy , Ruhm Loreen , Henning Anke , Scheffler Klaus 
Published: February 2021

PurposeTo develop an unshielded dipole transceiver array for human head imaging at 9.4 Tesla and to improve decoupling of adjacent dipole elements, a novel array design with modified passive dipole antennas was developed, evaluated, and tested.MethodsThe new array consisted of 8 bent folded‐end dipole elements placed in a single row and surrounding the head. Adjacent elements of RF transceiver arrays are usually decoupled by introducing circuits electrically connected to elements. These methods are difficult to use for dipole arrays because of the distant location of the adjacent antennas. A recently developed decoupling technique using passive dipoles is simple and does not require any electrical connection. However, common parallel passive dipoles can produce destructive interference with the RF field of the array itself. To minimize this interference, we placed the passive dipoles perpendicularly to the active dipoles and positioned them at the ends of the array. We also evaluated the effect of different passive dipoles on the array transmit performance. Finally, we optimized the array transmit performance by varying the length of the dipole folded portion.ResultsBy rotating the passive dipoles 90º and moving them toward the ends of the array, we minimized the destructive interference to an acceptable level without compromising decoupling and the transmit efficiency.ConclusionWhile keeping the benefits of the passive dipole decoupling method, the new modified dipoles produce substantially less destructive interference with the RF field of the array than the common design. The constructed transceiver array demonstrated good decoupling and whole‐brain coverage.
3D graphene/hexagonal boron nitride composite nanomaterials synergistically reduce the friction and wear of Steel‐DLC contacts
Authors: Qi Shunshun , Wei Xubing , Chen Lin , Geng Zhongrong , Luo Jinqiong , Lu Zhibin , Zhang Guangan 
Published: February 2021

AbstractGreen tribology is an engineering field, which is dedicated to reducing friction, wear and pollution to the environment. Diamond‐like carbon (DLC) films as coating is a very effective green friction material, but its friction of coefficient in the atmospheric environment still needs to be further reduced. Here, a common method for improving the tribological performance of DLC films in ambient atmosphere by adding 3D graphene/hexagonal boron nitride(h‐BN) composite nanomaterials as lubricant additive is proposed. By comparing with DLC film and other single additives, we can see that the 3D graphene/h‐BN composite nanomaterial as a lubricating additive reduce the friction coefficient and wear rate remarkably. By studying the tribological properties of the surface of the steel ball and DLC film, it is found that the friction protective film containing carbon, nitrogen and boron elements are formed on the surface. The presence of the friction layer can reduce friction efficiently, not only prevent the surface of the steel ball from being excessively worn, but also protect the DLC film from being damaged. The important thing is that it does not contain harmful elements and provides a new reference for the development of the next generation of oil‐free lubrication tribology. Accordingly, it is considered an environmentally friendly additive.
Extrapolation and Ce‐based implicit integration of anisotropic constitutive behavior
Authors: Areias Pedro , Rabczuk Timon , Ambrósio Jorge 
Published: February 2021

AbstractFor finite strain plasticity with both anisotropic yield functions and anisotropic hyperelasticity, we use the Kröner‐Lee decomposition of the deformation gradient to obtain a differential‐algebraic system (DAE) in the semi‐implicit form and solve it by an implicit Richardson‐extrapolated method based on intermediate substeps. The source is here the right Cauchy‐Green tensor and the consistent Jacobian of the second Piola‐Kirchhoff stress is determined with respect to this source. The system is composed by a smooth nonlinear first‐order differential equation and a non‐smooth algebraic equation. The development of a Richardson‐extrapolated implicit integrator for any hyperelastic case and any yield function is the goal of this work. The integration makes use of a backward‐Euler method for the flow law complemented by the solution of a yield constraint. The resulting system is solved by the Newton‐Raphson method to obtain the plastic multiplier and the elastic right Cauchy‐Green tensor . To ensure power consistency, we make use of the elastic Mandel stress construction. Iso‐error maps for three yield functions and three numerical examples are presented.
Pharmacokinetics and safety of ticagrelor in infants and toddlers with sickle cell disease aged <24 months
Authors: Duniva Inusa Baba Psalm , Inati Adlette , Maes Philip , Githanga Jessie , Ogutu Bernhards , Abboud Miguel R. , Miano Maurizio , Cela Elena , Nduba Videlis , Niazi Mohammad , Åstrand Magnus , Persson Kevin , Berggren Anders , Carlson Glenn 
Published: February 2021

AbstractInhibition of platelet activation may reduce vaso‐occlusion rates in patients with sickle cell disease (SCD). In the HESTIA4 (NCT03492931) study, 21 children with SCD received a single oral dose of the antiplatelet agent ticagrelor (0.1 mg/kg <6 months; 0.2 mg/kg ≥6 to <24 months). All patients had measurable ticagrelor plasma concentrations. Ticagrelor and active metabolite (AR‐C124910XX) exposure were comparable across all groups (<6 months, ≥6 to <12 months and ≥12 to <24 months). Ticagrelor was well tolerated. Palatability was generally acceptable. These data will be used to enable dose selection for further investigations of ticagrelor efficacy and safety in children with SCD.
COVID‐19 under 19: A meta‐analysis
Authors: Toba Nagham , Gupta Shreya , Ali Abdulrahman Y. , ElSaban Mariam , Khamis Amar H. , Ho Samuel B. , Popatia Rizwana 
Published: February 2021

AbstractBackgroundThe coronavirus disease 2019 (COVID‐19) pandemic continues to cause global havoc posing uncertainty to educational institutions worldwide. Understanding the clinical characteristics of COVID‐19 in children is important because of the potential impact on clinical management and public health decisions.MethodsA meta‐analysis was conducted for pediatric COVID‐19 studies using PubMed and Scopus. It reviewed demographics, co‐morbidities, clinical manifestations, laboratory investigations, radiological investigations, treatment, and outcomes. The 95% confidence interval (CI) was utilized.ResultsOut of 3927 articles, 31 articles comprising of 1816 patients were selected from December 2019 to early October 2020 and were defined by 77 variables. Of these studies 58% originated from China and the remainder from North America, Europe and the Middle East. This meta‐analysis revealed that 19.2% (CI 13.6%–26.4%) of patients were asymptomatic. Fever (57%, CI 49.7%–64%) and cough (44.1%, CI 38.3%–50.2%) were the most common symptoms. The most frequently encountered white blood count abnormalities were lymphopenia 13.5% (CI 8.2%–21.4%) and leukopenia 12.6% (CI 8.5%–18.3%). Ground glass opacities were the most common radiological finding of children with COVID‐19 (35.5%, CI 28.9%–42.7%). Hospitalization rate was 96.3% (CI 92.4%–98.2%) of which 10.8% (CI 4.2%–25.3%) were ICU admissions, and 2.4% (CI 1.7%–3.4%) died.ConclusionThe majority of pediatric patients with COVID‐19 were asymptomatic or had mild manifestations. Among hospitalized patients there remains a significant number that require intensive care unit care. Overall across the literature, a considerable level of understanding of COVID‐19 in children was reached, yet emerging data related to multisystemic inflammatory syndrome in children should be explored.
Hereditary pulmonary alveolar proteinosis as collateral damage from a large chromosomal deletion
Authors: Schmidt Anne , Kenia Priti , Morgan Cliff , Bush Andrew 
Published: February 2021

AbstractA girl with a known chromosomal deletion at Xp22.33, learning difficulties and short stature presented with dyspnea and dry cough and an abnormal chest X‐ray. Computed tomography was typical for pulmonary alveolar proteinosis (PAP), and the diagnosis was confirmed invasively. More detailed genetic analysis detected a homozygous deletion of the colony‐stimulating factor‐2‐receptor alpha subunit (CSF2RA) gene. In this patient, the Xp22.33 deletion affected 8 genes, including CSF2RA, leading to GM‐CSF receptor dysfunction and hereditary PAP. This is the first report of childhood interstitial lung disease (chILD) as collateral damage from a large chromosomal deletion.
Chest wall fistula in a patient with pyothorax‐associated lymphoma
Authors: Takahashi Saeko , Omura Kenshiro , Nakamura Morio 
Published: February 2021

Key messageFistula formation is an uncommon but serious therapeutic complication of pyothorax‐associated lymphoma (PAL) because it decreases the quality of life in patients. Furthermore, a collapsed lung may predispose to pneumonia. In PAL, the lesions might invade the skin and optimal irradiation dose, region, and timing should be carefully determined.
Early detection of marine non-indigenous species on Svalbard by DNA metabarcoding of sediment
Authors: van den Heuvel-Greve Martine J. , van den Brink Anneke M. , Glorius Sander T. , de Groot G. Arjen , Laros Ivo , Renaud Paul E. , Pettersen Ragnhild , Węsławski Jan Marcin , Kuklinski Piotr , Murk Albertinka J. 
Published: February 2021

AbstractNon-indigenous species (NIS) in the Arctic have an increased likelihood of arrival from ship traffic in the region, while the survival potential of the species becomes more likely in a warming environment. Monitoring is essential to detect the rate and magnitude of the establishment of NIS. In this study, a list of 123 potential marine NIS for Svalbard was drafted and the presence of marine NIS in soft sediment of Kongsfjorden in Svalbard was assessed using molecular metabarcoding techniques. For 37 species, including eight potential Arctic NIS, we generated new 18S and/or COI barcode sequences to improve the available online reference databases. In total, 299 species were identified in the sediment samples, including seven potential NIS. Three of these potential NIS have not been reported before in Svalbard: the harpacticoid copepod Euterpina acutifrons, and the ascidians Botrylloides violaceus and Molgula manhattensis. Another novel observation for Svalbard was the polychaete Chone mollis. Additional studies are needed to assess whether the NIS have been established on Svalbard and what their potential impact on the local system may be. Metabarcoding proved to be an effective monitoring tool to detect the presence of new species in Svalbard marine waters. We advise its use to set up a baseline record for the presence of NIS at points of entry, especially harbours. This approach is also valuable for biodiversity monitoring, in particular the detection of small organisms and life stages that are hard to identify using current visual techniques.
Reduction of CT artifacts from cardiac implantable electronic devices using a combination of virtual monoenergetic images and post-processing algorithms
Authors: Pennig Lenhard , Zopfs David , Gertz Roman , Bremm Johannes , Zaeske Charlotte , Große Hokamp Nils , Celik Erkan , Goertz Lukas , Langenbach Marcel , Persigehl Thorsten , Gupta Amit , Borggrefe Jan , Lennartz Simon , Laukamp Kai Roman 
Published: February 2021

Abstract
Objectives
To evaluate the reduction of artifacts from cardiac implantable electronic devices (CIEDs) by virtual monoenergetic images (VMI), metal artifact reduction (MAR) algorithms, and their combination (VMIMAR) derived from spectral detector CT (SDCT) of the chest compared to conventional CT images (CI).

Methods
In this retrospective study, we included 34 patients (mean age 74.6 ± 8.6 years), who underwent a SDCT of the chest and had a CIED in place. CI, MAR, VMI, and VMIMAR (10 keV increment, range: 100–200 keV) were reconstructed. Mean and standard deviation of attenuation (HU) among hypo- and hyperdense artifacts adjacent to CIED generator and leads were determined using ROIs. Two radiologists qualitatively evaluated artifact reduction and diagnostic assessment of adjacent tissue.

Results
Compared to CI, MAR and VMIMAR ≥ 100 keV significantly increased attenuation in hypodense and significantly decreased attenuation in hyperdense artifacts at CIED generator and leads (p < 0.05). VMI ≥ 100 keV alone only significantly decreased hyperdense artifacts at the generator (p < 0.05). Qualitatively, VMI ≥ 100 keV, MAR, and VMIMAR ≥ 100 keV provided significant reduction of hyper- and hypodense artifacts resulting from the generator and improved diagnostic assessment of surrounding structures (p < 0.05). Diagnostic assessment of structures adjoining to the leads was only improved by MAR and VMIMAR 100 keV (p < 0.05), whereas keV values ≥ 140 with and without MAR significantly worsened diagnostic assessment (p < 0.05).

Conclusions
The combination of VMI and MAR as well as MAR as a standalone approach provides effective reduction of artifacts from CIEDs. Still, higher keV values should be applied with caution due to a loss of soft tissue and vessel contrast along the leads.

Key Points
• The combination of VMI and MAR as well as MAR as a standalone approach enables effective reduction of artifacts from CIEDs.
• Higher keV values of both VMI and VMIMARat CIED leads should be applied with caution since diagnostic assessment can be hampered by a loss of soft tissue and vessel contrast.
• Recommended keV values for CIED generators are between 140 and 200 keV and for leads around 100 keV.