bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive Bibliometric Analysis of the Kynurenine Pathway in Mood Disorders: Focus on Gut Microbiota Research
Authors: Zhu Xiuqing , Hu Jinqing , Deng Shuhua , Tan Yaqian , Qiu Chang , Zhang Ming , Ni Xiaojia , Lu Haoyang , Wang Zhanzhang , Li Lu , Luo Yayan , Huang Shanqing , Xiao Tao , Liu Shujing , Li Xiaolin , Shang Dewei , Wen Yuguan 
Published: June 2021

Background: Emerging evidence implicates the dysregulated kynurenine pathway (KP), an immune-inflammatory pathway, in the pathophysiology of mood disorders (MD), including depression and bipolar disorder characterized by a low-grade chronic pro-inflammatory state. The metabolites of the KP, an important part of the microbiota-gut-brain axis, serve as immune system modulators linking the gut microbiota (GM) with the host central nervous system.Aim: This bibliometric analysis aimed to provide a first glimpse into the KP in MD, with a focus on GM research in this field, to guide future research and promote the development of this field.Methods: Publications relating to the KP in MD between the years 2000 and 2020 were retrieved from the Scopus and Web of Science Core Collection (WoSCC), and analyzed in CiteSpace (5.7 R5W), biblioshiny (using R-Studio), and VOSviewer (1.6.16).Results: In total, 1,064 and 948 documents were extracted from the Scopus and WoSCC databases, respectively. The publications have shown rapid growth since 2006, partly owing to the largest research hotspot appearing since then, “quinolinic acid.” All the top five most relevant journals were in the neuropsychiatry field, such as Brain Behavior and Immunity. The United States and Innsbruck Medical University were the most influential country and institute, respectively. Journal co-citation analysis showed a strong tendency toward co-citation of research in the psychiatry field. Reference co-citation analysis revealed that the top four most important research focuses were “kynurenine pathway,” “psychoneuroimmunology,” “indoleamine 2,3-dioxygenase,” and “proinflammatory cytokines,” and the most recent focus was “gut-brain axis,” thus indicating the role of the KP in bridging the GM and the host immune system, and together reflecting the field’s research foundations. Overlap analysis between the thematic map of keywords and the keyword burst analysis revealed that the topics “Alzheimer’s disease,” “prefrontal cortex,” and “acid,” were research frontiers.Conclusion: This comprehensive bibliometric study provides an updated perspective on research associated with the KP in MD, with a focus on the current status of GM research in this field. This perspective may benefit researchers in choosing suitable journals and collaborators, and aid in the further understanding of the field’s hotspots and frontiers, thus facilitating future research.
Decreased Peripheral BDNF Levels and Cognitive Impairment in Late-Life Schizophrenia
Authors: Huo Lijuan , Zheng Zhiwei , Lu Xiaobing , Wu Fengchun , Ning Yuping , Zhang Xiang Yang 
Published: June 2021

Objectives: There are relatively few studies on mechanisms of cognitive deficits in late-life schizophrenia (LLS). Brain-derived neurotrophic factor (BDNF), as an important neuroplastic molecule, has been reported to be involved in neurocognitive impairment in schizophrenia. This study aimed to examine whether peripheral BDNF levels were associated with cognitive deficits in LLS, which has not been explored yet.Methods: Forty-eight LLS patients and 45 age-matched elderly controls were recruited. We measured all participants on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for cognition and serum BDNF levels. Psychopathological symptoms in patients were assessed by the Positive and Negative Syndrome Scale (PANSS).Results: The levels of BDNF in LLS patients were significantly lower than those in healthy controls (8.80 ± 2.30 vs. 12.63 ± 5.08 ng/ml, p &lt; 0.001). The cognitive performance of LLS patients was worse than that of the controls on RBANS total score and scores of immediate memory, attention, language, and delayed memory (all p ≤ 0.005). BDNF was positively associated with attention in LLS patients (r = 0.338, p = 0.019).Conclusion: Our findings suggest that older patients with schizophrenia exhibit lower BDNF levels and more cognitive deficits than older controls, supporting the accelerated aging hypothesis of schizophrenia. Moreover, decreased BDNF is related to attention deficits, indicating that BDNF might be a candidate biomarker of cognitive impairments in LLS patients.
A Systematic Review and Bibliometric Analysis of the Scientific Literature on the Early Phase of COVID-19 in Italy
Authors: Turatto Federica , Mazzalai Elena , Pagano Federica , Migliara Giuseppe , Villari Paolo , De Vito Corrado 
Published: June 2021

Background: Studying the scientific literature about COVID-19 and Italy, one of the first countries to be hit by the pandemic, allows an investigation into how knowledge develops during a public health emergency.Methods: A systematic review of the literature was conducted to identify articles published on the topic between January and April 2020. Articles were classified according to type of study. Co-occurrence of terms, and geographic and temporal trends were analyzed.Results: Of the 238 articles included in the systematic review, the majority (37%) focused on hospital and clinical management of COVID-19, while 23.9% were commentaries. Epidemiological studies constituted 45.5% of the articles published by authors with non-Italian affiliations.Conclusion: The scientific articles on COVID-19 in Italy were varied in type of study, though with limited international impact. The lockdown and the pressure placed on hospitals during the first wave of the pandemic mainly resulted in publications on disease management and commentaries.
Primer caso de infección por Neisseria meningitidis con susceptibilidad reducida a cefalosporinas de tercera generación reportado en Costa Rica.
Authors: García Quirós Christian , Borbón Juan Diego Salazar , Barillas Lamuño Hilver , Riday Morúa Jessica 
Published: June 2021

La meningitis corresponde a la inflamación de la leptomeninges, tejido que rodea el cerebro y la médula espinal definido por conteo anormal de glóbulos blancos en el líquido cefalorraquídeo. Entre los microorganismos principales asociados a dicha patología se encuentran el Streptococcus pneumoniae, estreptococos del grupo B, Haemophilus influenzae, Neisseria meningitidis, y en adultos mayores o caso de inmunodeficiencia Listeria monocytogenes. La presentación clínica se caracteriza principalmente por fiebre, rigidez nucal y alteración de la conciencia. En la mayoría de los casos asocian leucocitosis y elevación de reactantes de fase aguda; sin embargo, el diagnóstico definitivo se basa en el aislamiento del patógeno en cultivo de líquido cefalorraquídeo. El tratamiento se enfoca en la erradicación del foco infeccioso mediante terapia antibiótica y prevención de secuelas y complicaciones graves. Describimos el caso de un paciente con episodio convulsivo en contexto febril en quien se documenta meningitis causada por meningococo resistente a penicilina y con sensibilidad disminuida para cefalosporinas de tercera generación.
Psoriasis:
Authors: Barboza Hernández Wady Mauricio , Sobrado Esquivel Fabian Leonardo 
Published: June 2021

En el contexto de atención primaria en salud, la valoración, diagnóstico y manejo de patologías dermatológicas es de suma frecuencia, siendo la psoriasis una de ellas. La psoriasis es una enfermedad inflamatoria, sistémica, crónica, de base genética, mediada inmunológicamente. Puede ser desencadenada y/o agravada por múltiples factores.
Dada su relativa frecuencia en la consulta médica general, el objetivo de este artículo es, actualizar y revisar algunos conceptos básicos de la patología, para su adecuado abordaje.
PEDAGOGICAL ASPECTS OF THE FORMATION OF THE LEGAL CULTURE OF STUDENTS OF HIGHER EDUCATIONAL INSTITUTIONS IN THE VOCATIONAL EDUCATION SYSTEM
Authors: Туркаева Л. В. 
Published: June 2021

На сегодняшний день в условиях низкого показателя правовой культуры российского общества проблема правовой социализации молодежи становится настолько актуальной, что затрагивает интересы многих специалистов в различных областях деятельности. Прежде всего такое повышенное внимание объясняется такими факторами, как социальная трансформация личности и модификация образовательной системы, которые в первую очередь способствуют определенным трудностям в процессе правовой адаптации подрастающего поколения к новым реалиям окружающего мира. В данной работе анализируются новейшие тенденции в развитии методики преподавания правовых дисциплин в высших учреждениях профессиональной системы образования. Кроме того, представлено влияние правовой культуры на поведение человека при реализации творческого потенциала в процессе правовой деятельности и социального взаимодействия.
Today, in the conditions of a low indicator of the legal culture of Russian society, the problem of legal socialization of young people is becoming so urgent that it affects the interests of many specialists in various fields of activity. First, such increased attention is explained by certain factors such as the social transformation of the individual and the modification of the educational system, which, first of all, contribute to certain difficulties in the process of legal adaptation of the younger generation to the new realities of the surrounding world. This paper analyzes the latest trends in the development of methods of teaching legal disciplines in higher institutions of the professional education system. In addition, the influence of legal culture on human behavior in the implementation of creative potential in the process of legal activity and social interaction is presented.
ON THE METHODOLOGY OF FORECASTING THE FUTURE OF THE NATIONAL REPUBLICS OF THE NORTH CAUCASUS
Authors: Билалов М. И. 
Published: June 2021

На примере публикаций в СМИ критически осмысливаются фактологизм, отсутствие цельной методологии и идеологии прогнозирования будущего республик Северного Кавказа. Автор отвергает скептицизм и пессимизм в оценке перспектив северокавказских народов. Обосновывается неприемлемость либерализма как методологии современного социального развития. Предлагаются основополагающие подходы в виде исторических закономерностей, идеалов и норм евразийства, соответствующие антилиберализму, антиглобализму и альтерглобализму, необходимые как методологические установки для определения перспектив народов постсоветского пространства. Сохранение российской и северокавказской идентичности, единство народов региона в составе России, евразийская цивилизация, гражданское общество с региональными базовыми ценностями и т. п. должны стать альфой и омегой не только общественно-политических и гуманитарных исследований, но и публикаций СМИ, прогнозирующих будущее национальных республик Северного Кавказа.
On the example of publications in the media, factology is critically interpreted, the lack of a coherent methodology and ideology for predicting the future of the North Caucasus republics. The author rejects skepticism and pessimism in assessing the prospects of the North Caucasian peoples. The article substantiates the unacceptability of liberalism as a methodology of modern social development. The fundamental approaches in the form of historical laws, ideals and norms of eurasianism, corresponding to anti-liberalism, anti-globalism and alter-globalism, necessary as methodological guidelines for determining the prospects of the peoples of the post-Soviet space, are proposed. The conservation of the Russian and North Caucasian identity, the unity of the peoples of the region within Russia, the Eurasian civilization, civil society with regional basic values, etc. should become the alpha and omega not only of socio-political and humanitarian studies, but also of media publications that predict the future of the national republics of the North Caucasus.
FROM THE EDITOR
Authors: Melber Henning 
Published: June 2021

With issue No 1/2013, this journal changed in several respects. Under a new editor-in-chief, the Strategic Review for Southern Africa, then published for 35 years, turned into an open access journal with a redesigned look. But the makeoveraimed at more than merely cosmetic changes. As outlined in the introduction of that issue, the changing context both in South Africa as well as globally, motivated a conceptual re-positioning, that also modified the subject-related thematic framework1). Since then, thanks to many contributors offering a wide range of topicalanalyses, we hopefully managed to live up to at least some of the expectations created.
After five years, it is now time to hand editorial responsibility to a new generation of scholars groomed in the spirit of democratic South Africa. This, therefore, is the last issue for me as the editor-in-chief. While I welcomed the privilege to lead the journal towards implementing a modified agenda, I now welcome the opportunity to move out of the way and pursue other tasks. I thank all those in the editorial group and the advisory board who accompanied and supported me during the last years. I am especially grateful to Maxi Schoeman, who felt I would be the right choice for this task. Special thanks go also to Wilma Martin, without her assistance none of the last eleven issues would have become a reality.
El modelo de justicia transicional y su relación con la justicia retributiva en Colombia
Authors: Torres Vásquez Henry , Echeverry Beltrán Claudia Rocío , Ortiz Vargas Danilo Alfredo 
Published: June 2021

En este trabajo se analiza la justicia transicional como una forma diferente de hacer justicia, que se aplica de manera excepcional y durante un determinado tiempo. Históricamente se ha entendido como el conjunto de acciones de todo tipo a las que el Estado acude para superar situaciones largas de conflicto armado, y en las que la solución es el diálogo entre partes.
Es una justicia muy distinta al modelo clásico de derecho penal ordinario, el cual es se emplea en todo tiempo y lugar del territorio nacional; es claro que, a pesar de existir una jurisdicción especial para la paz, el derecho penal sigue vigente. Aun así, a raíz del Acuerdo de Paz entre las Farc Ep y el gobierno de Juan Manuel Santos en la actualidad la preferencia la tiene la Jurisdicción Especial para la Paz para conocer conductas criminales cometidas con anterioridad al 1 de diciembre de 2016 perpetradas con ocasión y en desarrollo del conflicto armado interno en Colombia.
Este artículo se enfoca en analizar las tensiones y estudia si se complementan la justicia restaurativa en la justicia penal convencional y la justicia de transición y su componente de justicia restaurativa, modelos actualmente vigentes en Colombia. Se concluye que no existe tensión y que ambas formas de justicia integran un hibrido que es un modelo de justicia específicamente destinada a solventar los problemas derivados de haber vivido décadas de conflicto armado no internacional en los que hubo millones de víctimas y en las que el derecho penal ha resultado insignificante.
JAK Be Nimble: Reviewing the Development of JAK Inhibitors and JAK Inhibitor Combinations for Special Populations of Patients with Myelofibrosis
Authors: Kuykendall Andrew T. , Komrokji Rami S. 
Published: June 2021

ABSTRACT
Myelofibrosis (MF) is a myeloproliferative neoplasm hallmarked by uncontrolled blood counts, constitutional symptoms, extramedullary hematopoiesis, and an increased risk of developing acute myeloid leukemia. Janus kinase (JAK) inhibitors are the most common treatment for MF due to their ability to reduce spleen size and improve disease-related symptoms; however, JAK inhibitors are not suitable for every patient and their impact on MF is limited in several respects. Novel JAK inhibitors and JAK inhibitor combinations are emerging that aim to enhance the treatment landscape, providing deeper responses to a broader population of patients with the continued hope of providing disease modification and improving long-term outcomes. In this review, we highlight several specific areas of unmet need within MF. Subsequently, we review agents that target those areas of unmet need, focusing specifically on the JAK inhibitors, momelotinib, pacritinib, itacitinib, and NS-018 as well as JAK inhibitor combination approaches using CPI-0610, navitoclax, parsaclisib, and luspatercept.
Concepções de Avaliação da Aprendizagem no Ensino de Ciências pela Pedagogia de Projetos: uma revisão sistemática de produções científicas do período de 2013 a 2017
Authors: Vargas Bozzato Carla , Almeida Barbosa Renan , Goulart Ligia Beatriz , Nunes Garcia Rosane 
Published: June 2021

O presente artigo investiga sobre as concepções a respeito da avaliação da aprendizagem que permeiam produções científicas relacionadas ao Ensino de Ciências da Natureza por meio da Pedagogia de Projetos (PP), na Educação Básica. Trata-se de um estudo bibliográfico que realiza uma Revisão Sistemática de Literatura de teses e dissertações nos bancos de dados da CAPES e LUME, no período de 2013 a 2017, que resultou em dez (10) pesquisas selecionadas. A avaliação das aprendizagens na PP é apontada como uma prática pedagógica processual que precisa ser repensada em uma perspectiva formativa, rompendo com a concepção classificatória, no sentido de promover a aprendizagem. Assim, requer a adoção de estratégias e instrumentos de avaliação diversificados, que possibilitem o acompanhamento constante, o diagnóstico e a participação ativa dos sujeitos envolvidos, bem como fornecer elementos para o redirecionamento do ensino para uma prática inclusiva, que esteja a serviço da efetivação das aprendizagens.
Algorithms for the automated correction of vertical drift in eye-tracking data
Authors: Carr Jon W. , Pescuma Valentina N. , Furlan Michele , Ktori Maria , Crepaldi Davide 
Published: June 2021

AbstractA common problem in eye-tracking research is vertical drift—the progressive displacement of fixation registrations on the vertical axis that results from a gradual loss of eye-tracker calibration over time. This is particularly problematic in experiments that involve the reading of multiline passages, where it is critical that fixations on one line are not erroneously recorded on an adjacent line. Correction is often performed manually by the researcher, but this process is tedious, time-consuming, and prone to error and inconsistency. Various methods have previously been proposed for the automated, post hoc correction of vertical drift in reading data, but these methods vary greatly, not just in terms of the algorithmic principles on which they are based, but also in terms of their availability, documentation, implementation languages, and so forth. Furthermore, these methods have largely been developed in isolation with little attempt to systematically evaluate them, meaning that drift correction techniques are moving forward blindly. We document ten major algorithms, including two that are novel to this paper, and evaluate them using both simulated and natural eye-tracking data. Our results suggest that a method based on dynamic time warping offers great promise, but we also find that some algorithms are better suited than others to particular types of drift phenomena and reading behavior, allowing us to offer evidence-based advice on algorithm selection.
Critical analysis of the regulatory requirements for carbon dioxide fire extinguishing in the tanks with oil products
Authors: Копылов Сергей Николаевич , Смирнов Николай Васильевич , Казаков Алексей Васильевич 
Published: June 2021

Показана недостаточность обоснования расчетных параметров установок углекислотного пожаротушения, приведенных в нормативной документации для случая противопожарной защиты резервуаров с нефтью и нефтепродуктами. Применение углекислоты для пожаротушения в резервуарах с нефтью и нефтепродуктами приведет к формированию больших зон загазованности, опасных для присутствующих людей и выводящих из строя технику, участвующую в тушении.
Experimental background of the regulatory requirements for carbon dioxide automatic fire extinguishing systems to protect fuel tanks is analyzed. It is shown that justification of the design parameters of such systems is not sufficient. Experimental data on carbon dioxide fire extinguishing in the fuel tanks having a volume of more than 5000 m are unknown, so there is an unjustified normative expansion of the scope of application of CO fire extinguishing systems for the protection of big tanks with oil and petroleum products. There has not been investigated the issue of CO efficiency at high air temperature and in the presence of wind. It is also shown that there is a very short period of time since the moment of ignition till the moment of activation of extinguishing system during which automatic carbon dioxide fire suppression has conditionally confirmed effectiveness. Even a small delay in activation of the system or late detection of a fire will make CO ineffective. The use of carbon dioxide to extinguish fires in tanks with oil and petroleum products will lead to formation of large areas of gas contamination which are dangerous for people and also disable the equipment involved in fire fighting. Thus, it is possible to conclude that the design parameters of carbon dioxide fire extinguishing systems specified in the regulatory documentation for the case of fire protection of tanks with oil and petroleum products are insufficiently justified.
High Spatial Resolution Observations of Molecular Lines toward the Protoplanetary Disk around TW Hya with ALMA
Authors: Nomura Hideko , Tsukagoshi Takashi , Kawabe Ryohei , Muto Takayuki , Kanagawa Kazuhiro D. , Aikawa Yuri , Akiyama Eiji , Okuzumi Satoshi , Ida Shigeru , Lee Seokho , Walsh Catherine , Millar T. J. 
Published: June 2021

Abstract
We present molecular line observations of 13CO and C18O J = 3 − 2, CN N = 3 − 2, and CS J = 7 − 6 lines in the protoplanetary disk around TW Hya at a high spatial resolution of ∼9 au (angular resolution of 0.″15), using the Atacama Large Millimeter/Submillimeter Array. A possible gas gap is found in the deprojected radial intensity profile of the integrated C18O line around a disk radius of ∼58 au, slightly beyond the location of the au-scale dust clump at ∼52 au, which resembles predictions from hydrodynamic simulations of planet–disk interaction. In addition, we construct models for the physical and chemical structure of the TW Hya disk, taking account of the dust surface density profile obtained from high spatial resolution dust continuum observations. As a result, the observed flat radial profile of the CN line intensities is reproduced due to a high dust-to-gas surface density ratio inside ∼20 au. Meanwhile, the CO isotopologue line intensities trace high temperature gas and increase rapidly inside a disk radius of ∼30 au. A model with either CO gas depletion or depletion of gas-phase oxygen elemental abundance is required to reproduce the relatively weak CO isotopologue line intensities observed in the outer disk, consistent with previous atomic and molecular line observations toward the TW Hya disk. Further observations of line emission of carbon-bearing species, such as atomic carbon and HCN, with high spatial resolution would help to better constrain the distribution of elemental carbon abundance in the disk gas.