bluuebunny/crossref_metadata_2025_split huggingface dataset:
Umbelliferone attenuates glycerol‐induced myoglobinuric acute kidney injury through peroxisome proliferator‐activated receptor‐γ agonism in rats
Authors: Kaur Tajpreet , Singh Damanpreet , Pathak Devendra , Singh Amrit P. , Singh Balbir 
Published: August 2021

AbstractRhabdomyolysis is a clinical syndrome caused by damage to skeletal muscle, which consequently releases breakdown products into circulation and causes acute kidney injury (AKI) in humans. Intramuscular injection of glycerol mimics rhabdomyolysis and associated AKI. In this study, we explored the role of umbelliferone against glycerol‐induced AKI in rats. Kidney function was assessed by measuring serum creatinine, urea, electrolytes, and microproteinuria. Renal oxidative stress was quantified using thiobarbituric acid reactive substances, superoxide anion generation, and reduced glutathione assay. Renal histological changes were determined using periodic acid Schiff and hematoxylin‐eosin staining, and immunohistology of apoptotic markers (Bax, Bcl‐2) was done. Serum creatine kinase was quantified to assess glycerol‐induced muscle damage. Umbelliferone attenuated glycerol‐induced change in biochemical parameters, oxidative stress, histological alterations, and renal apoptosis. Pretreatment with bisphenol A diglycidyl ether, a peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) antagonist, attenuated umbelliferone‐mediated protection. It is concluded that umbelliferone attenuates glycerol‐induced AKI possibly through PPAR‐γ agonism in rats.
Predictors of mothers' participation in a mother‐only coparenting intervention conducted in fatherhood programs
Authors: Fagan Jay , Pearson Jessica 
Published: August 2021

AbstractWhile fatherhood programs are increasingly implementing coparenting classes for mothers, very little is known about the circumstances that could increase or inhibit a mother's participation in joining such a class. The current study uses ecological systems theory to explore the microsystems, mesosystems, and macrosystems that relate to mothers' participation in a coparenting class. Pretest data from 277 fathers attending fatherhood programs are used to predict mothers' participation in a mother‐only coparenting class. Fathers' perceived relationship quality, perceptions of the coparenting alliance, recent legal challenges, and residing in a rural/small‐town community were significantly associated with whether the mother participated in the coparenting program. Fatherhood programs should address the issues that appear to deter mothers from participating in coparenting interventions, including high levels of couple conflict, recent father incarceration, and recent father trouble with the law.
Adapting the Utrecht‐Management of Identity Commitments Scale to assess engineering identity formation
Authors: Li Nan , Fan Weihua , Wiesner Margit , Arbona Consuelo , Hein Sascha 
Published: August 2021

AbstractBackgroundEngineering identity is associated with students' academic success and retention in engineering programs. However, there is a lack of psychometrically evaluated measures for assessing engineering identity formation.PurposeThis cross‐sectional study aimed to adapt the Utrecht‐Management of Identity Commitments Scale (U‐MICS) to assess engineering identity formation and evaluate its factor structure, reliability, and associations with demographic characteristics of engineering students.Design/MethodSurvey data were collected from 237 engineering students. Confirmatory factor analysis (CFA) was performed to examine the factor structure of the U‐MICS. Multiple indicators multiple causes (MIMIC) analysis was performed to investigate how demographic characteristics of engineering students related to the latent variables underlying the U‐MICS.ResultsCFA supported the hypothesized three‐dimensional model of identity formation (i.e., commitment, in‐depth exploration, and reconsideration of commitment) after excluding one item originally designed for assessing in‐depth exploration. Good internal consistencies were found for each subscale (Cronbach's α = .72–.88). MIMIC analysis showed mean differences in the commitment factor and the in‐depth exploration factor by undergraduate classification and mean differences in the reconsideration of commitment factor by race/ethnicity, but no differences in the three latent factors by gender and transfer status.ConclusionsThe U‐MICS may be a viable measure to assess engineering identity formation. This measure can help researchers gauge how engineering students develop, validate, and revise their commitment to pursue an engineering degree.
Digestion of bamboo compared to grass and lucerne in a small hindgut fermenting herbivore, the guinea pig (Cavia porcellus)
Authors: De Cuyper Annelies , Winkler Daniela E. , Tütken Thomas , Bosch Guido , Hummel Jürgen , Kreuzer Michael , Muñoz Saravia Arturo , Janssens Geert P. J. , Clauss Marcus 
Published: August 2021

AbstractBamboo is an enigmatic forage, representing a niche food for pandas and bamboo lemurs. Bamboo might not represent a suitable forage for herbivores relying on fermentative digestion, potentially due to its low fermentability. To test this hypothesis, guinea pigs (n = 36) were used as model species and fed ad libitum with one of three forages (bamboo, lucerne, or timothy grass) in a fresh or dried state, with six individuals per group, for 3 weeks. The nutrient composition and in vitro fermentation profile of bamboo displayed low fermentation potential, i.e. high lignin and silica levels together with a gas production (Hohenheim gas test) at 12 h of only 36% of that of lucerne and grass. Although silica levels were more abundant in the leftovers of (almost) all groups, guinea pigs did not select against lignin on bamboo. Dry matter (DM) intake was highest and DM digestibility lowest on the bamboo forage. Total short‐chain fatty acid levels in caecal content were highest for lucerne and lowest for grass and bamboo. Bamboo‐fed guinea pigs had a lower body weight gain than the grass and lucerne group. The forage hydration state did not substantially affect digestion, but dry forage led to a numerically higher total wet gut fill. Although guinea pigs increased DM intake on the bamboo diet, the negative effects on fermentation of lignin and silica in bamboo seemed overriding. For herbivores that did not evolutionary adapt, bamboo as an exclusive food resource can be considered as inadequate.
An (F1,F4)‐partition of graphs with low genus and girth at least 6
Authors: Chen Min , Raspaud André , Yu Weiqiang 
Published: August 2021

AbstractLet be a graph. If the vertex set can be partitioned into two nonempty subsets and such that and are graphs with maximum degree at most and , respectively, then we say that has a ‐partition. A similar definition can be given for the notation ‐partition if is a forest with maximum degree at most , where . The maximum average degree of is defined to be mad. In this paper, we prove that every graph with mad admits an ‐partition. As a corollary, every graph with low genus and girth at least 6 admits an ‐partition. This improves a result of Borodin and Kostochka saying that every graph with mad admits a ‐partition.
Multi-omics analysis of the expression and prognostic value of the butyrophilins in breast cancer
Authors: Ren He , Li Shuliang , Liu Xin , Li Wanjing , Hao Jianlei , Zhao Na 
Published: August 2021

AbstractButyrophilins (BTNs) belong to the immunoglobulin superfamily of transmembrane proteins and play a role in the regulation of lymphocyte activation, several autoimmune diseases, and the progression of human cancers. However, the associated clinicopathologic characteristics and prognostic value of BTNs in breast cancer remain unknown. This study aimed to discover potential key related BTN genes and signaling pathways in breast cancer, which could provide new insights for immune-based strategies. In the present study, the mRNA expression level and prognostic value of BTN2A1, BTN3A1, BTN3A2, BTN3A3, BTNL2, BTNL9, ERMAP, and MOG were measured. Up-regulation of these genes was significantly correlated with improved overall and relapse-free survival. We then analyzed the prognostic outcomes of breast cancer subtypes, genetic alterations, interaction networks, and the functional enrichment of eight BTN family genes. Our results showed that these eight genes played essential roles in tumor progression. Furthermore, an immune infiltration analysis indicated that most candidate BTN family members were associated with intratumoral immune cell infiltration, especially that of γδ T cells. Finally, gene set enrichment analysis for a single hub gene revealed that each BTN gene played a vital role in tumor progression through immune signaling pathways. These findings provided new insights into breast cancer pathogenesis and identified eight potential biomarkers for breast cancer.
Epidemiologic characteristics of cases with reinfection, recurrence, and hospital readmission due to COVID‐19: A systematic review and meta‐analysis
Authors: Sotoodeh Ghorbani Sahar , Taherpour Niloufar , Bayat Sahar , Ghajari Hadis , Mohseni Parisa , Hashemi Nazari Seyed Saeed 
Published: August 2021

AbstractRecent studies reported that some recovered COVID‐19 patients have tested positive for virus nucleic acid again. A systematic search was performed in Web of Science, PubMed, Scopus, and Google Scholar up to March 6, 2021. The pooled estimation of reinfection, recurrence, and hospital readmission among recovered COVID‐19 patients was 3, 133, and 75 per 1000 patients, respectively. The overall estimation of reinfection among males compared to females was greater. The prevalence of recurrence in females compared to males was more common. Also, hospital readmission between sex groups was the same. There is uncertainty about long‐term immunity after SARS‐Cov‐2 infection. Thus, the possibility of reinfection and recurrence after recovery is not unexpected. In addition, there is a probability of hospital readmission due to adverse events of COVID‐19 after discharge. However, with mass vaccination of people and using the principles of prevention and appropriate management of the disease, frequent occurrence of the disease can be controlled.
Spatially offset Raman spectroscopy: A convenient and rapid tool to distinguish cheese made with milks from different animal species
Authors: Ostovar pour Saeideh , Afshari Roya , Landry Jeremy , Pillidge Christopher , Gill Harsharn , Blanch Ewan 
Published: August 2021

AbstractAuthenticity is of great importance in the food industry. There is a need for rapid, reliable methods that can ‘fingerprint’ foods and show their composition. In this study, we trialled spatially offset Raman spectroscopy (SORS) as a convenient method to distinguish between cheeses of different animal origins. SORS is a rapid non‐destructive method that can be applied to food products in various packaging materials such as plastic. The technique also has the capability to monitor larger volume of sample in contrast with conventional Raman spectroscopy. Eight cheese products were examined in relation to, and discrimination between them was based upon, protein and fat content, phospholipids and carotenoids. Chemometrics analysis further enabled differentiation of even closely related cheese types. SORS has great potential as a rapid, real‐time tool for screening of foods for authenticity, and in the future, this could be extended to monitoring for food quality targeting specific molecules.
Surgical treatment of gastrointestinal tumors in a COVID‐19 pandemic hospital: Can open versus minimally invasive surgery be safely performed?
Authors: Özdemir Yılmaz , Temiz Ayetullah 
Published: August 2021

AbstractPurposeIn order for patients with gastrointestinal cancer not to suffer the consequences of delayed treatment, they should be operated on in pandemic hospitals under adequate conditions. We aimed to discuss the outcomes of our gastrointestinal cancer surgery patients and to present our patient management recommendations to resume operative treatment during the ongoing COVID‐19 pandemic while taking into account hospital facilities.Materials and MethodsThis study included 129 gastrointestinal cancer patients who underwent surgery between March 2020 and May 2021 in the gastrointestinal surgery clinic of our hospital, which was assigned as a pandemic hospital in March 2020. Patients' demographic characteristics and preoperative and postoperative findings were recorded.ResultsAmong the patients, 42.6% (n = 55) were female and 57.3% (n = 74) were male. The mean age was 61.89 ± 3.4 years. The primary tumor organs were the stomach 37.2% (n = 48), pancreas 36.4% (n = 47), rectum 11.6% (n = 15), colon 8.5% (n = 11), and esophagus 6.2% (n = 8). The patients were treated with open (75.2%, n = 97) or minimally invasive surgery (24.8%, n = 32; laparoscopic 11.6%, n = 15; robotic 13.2%, n = 17). Eight patients tested positive for COVID‐19 before surgery. No patients developed COVID‐19 during postoperative intensive care or after being moved to the floor unit. There was no COVID‐19‐related morbidity or mortality.ConclusionFailure to treat gastrointestinal cancer patients during the pandemic may result in undesirable consequences, such as stage shift and mortality. Cancer patients can be treated safely with conventional and minimally invasive surgery guided by current recommendations and experience.
Hydraulic dissection technique during endoscopic sinus surgery using a novel balloon sinus dilation device
Authors: Schmale Isaac L. , Yao William C. , Citardi Martin J. 
Published: August 2021

AbstractBackgroundMore than a decade after its introduction, some rhinologic surgeons have incorporated the technique of balloon sinus dilation (BSD) technology into “hybrid” endoscopic sinus surgery (ESS) procedures. A novel BSD device which can be placed over standard surgical instruments, including surgical navigation instruments, has recently been introduced. We present a case series in which this device was used as a hydraulic dissection tool to aid safe efficient surgery in difficult‐to‐access locations of the paranasal sinuses during hybrid ESS procedures.ObjectiveHighlight the potential role of hydraulic dissection techniques during ESS utilizing BSD.MethodsRetrospective case series of patients who underwent ESS performed in part with a novel BSD device.ResultsA total of 10 patients who underwent hybrid ESS with BSD were reviewed. In all 10 cases, the novel BSD device was used without complication. The device was used over straight and curved suctions while being tracked with surgical navigation in all cases. Thirteen posterior ethmoid dissections, 12 sphenoidotomies, and 8 frontal sinusotomies were assisted with the device. For the selected dissections in which the balloon was utilized, the operating surgeon found it to be helpful in creating more space in difficult to access areas which allowed for continued safe surgical dissection.ConclusionsSinus balloon devices can be used as a hydraulic dissection tool and may be a useful adjunct during ESS. The novel dilation system used in this study, which deploys a sinus balloon device over standard surgical instruments with surgical navigation, provides even more opportunity to accurately dissect difficult areas of the paranasal sinuses safely and efficiently. Further studies evaluating the exact role of sinus balloon devices used as a hydraulic dissection tool during ESS are warranted.Level of Evidence4.
Dietary lysophospholipids reduce lymphatic cholesterol transport compared with dietary phospholipids in thoracic lymph‐duct cannulated rats
Authors: Takeyama Ai , Teramoto Asami , Wang Tianyu , Hayashi Takuya , Tanaka Yasutake , Sato Masao , Shirouchi Bungo 
Published: August 2021

AbstractDietary phospholipids have been traditionally known to affect micelle formation. Egg yolk‐derived lysophospholipids (LysoPL) are commercially available. We investigated the effects of dietary LysoPL on lymphatic lipid transport. We also compared sn‐1 LysoPL and sn‐2 LysoPL, which have different fatty acyl esterification positions. Thoracic lymph duct‐cannulated rats were fed a diet supplemented with egg yolk‐derived sn‐1 LysoPL, sn‐2 LysoPL, or phospholipids (PL). The amount of lymphatic lipid transport was also evaluated. Time courses of transport were applied to the one‐compartment model as one of the pharmacokinetic analyses. The solubility of cholesterol in bile acid micelles was measured. Compared to the PL diet, the sn‐1 and sn‐2 LysoPL diets significantly reduced the lymphatic transport of cholesterol. There were no differences in the lymphatic PL and TAG transport. There was no difference in cholesterol transport between the sn‐1 LysoPL group and the sn‐2 LysoPL group; however, the transport rate constant at a decrease in lymphatic cholesterol was lower in the sn‐1 LysoPL group than in the sn‐2 LysoPL group. Cholesterol solubility in bile acid micelles was significantly decreased in the sn‐1 LysoPL and sn‐2 LysoPL groups compared to that in the PL group. Dietary LysoPL affects the behavior of intestinal cholesterol and suppresses lymphatic cholesterol transport.
Safety and efficacy of fractional radiofrequency for the treatment and reduction of acne scarring: A prospective study
Authors: Eubanks Stephen W. , Solomon James A. 
Published: August 2021

AbstractObjectivesSkin rejuvenation with radiofrequency has been a widely used treatment modality for the safe and efficient remodeling of the dermis and revision of textural irregularities, achieved with minimal downtime. The efficacy of fractional radiofrequency (FRF) specifically for acne scarring has not been widely established. The objective of this clinical trial was to establish the efficacy and safety of FRF for moderate to severe acne scarring in a wide range of Fitzpatrick skin types using two different applicator tips to deliver energy to the skin (80‐pin of up to 124 mJ/pin and 160‐pin of up to 62 mJ/pin).MethodsEnrolled subjects received a series of three FRF treatments to the full face, each 4 weeks apart. A visual analog scale was utilized to assess pain of the treatment. Subject satisfaction questionnaires were completed at follow‐up visits at 6 and 12 weeks post final treatment. Photographs were graded for change by three blinded evaluators using the Global Aesthetic Improvement Scale (GAIS).ResultsImage sets of 23 enrolled subjects were assessed by blinded evaluation, showing a statistically significant improvement (p = 0.009) from the baseline visit to the 12‐week follow‐up on the GAIS for acne scarring. Subject satisfaction was high with subjects giving an average satisfaction score of 3.27 (“satisfied”) out of 4. Pain was “mild” as treatments were rated an average of 2.15 on a 10‐point visual analog scale. The GAIS score of the 80‐pin tip improved patients' acne scars treated with that applicator by 1.06 points and 0.85 for the 160‐pin tip. Ninety‐five percent (95.5%) of subjects reported either a mild, moderate, or significant improvement to their treatment area. Ninety‐one percent of subjects reported that they would recommend the treatment to a friend.ConclusionFRF produced a statistically significant improvement in acne scarring when assessed by independent blinded evaluators. No serious adverse events resulted from treatment by either applicator tip. Treatment pain was low and tolerable among subjects of all Fitzpatrick skin types. Subjects had high levels of satisfaction with the results.
Co‐Delivery of Doxorubicin and Chloroquine by Polyglycerol Functionalized MoS2 Nanosheets for Efficient Multidrug‐Resistant Cancer Therapy
Authors: Xu Shaohui , Zhong Yinan , Nie Chuanxiong , Pan Yuanwei , Adeli Mohsen , Haag Rainer 
Published: August 2021

Abstract2D MoS2 has shown a great potential in biomedical applications, due to its superior loading capacity, photothermal property, and biodegradation. In this work, polyglycerol functionalized MoS2 nanosheets with photothermal and pH dual‐stimuli responsive properties are used for the co‐delivery of doxorubicin and chloroquine and treatment of multidrug‐resistant HeLa (HeLa‐R) cells. The polyglycerol functionalized MoS2 nanosheets with 80 nm average size show a high biocompatibility and loading efficiency (≈90%) for both drugs. The release of drugs from the nanosheets at pH 5.5 is significantly promoted by laser irradiation leading to efficient destruction of incubated HeLa‐R cells. In vitro evaluation shows that the designed nanoplatform has a high ability to kill HeLa‐R cells. Confocal experiments demonstrate that the synthesized drug delivery system enhances the cellular uptake of DOX via folic acid targeting ligand. Taking advantage of the combined properties including biocompatibility and targeting ability as well as high loading capacity and photothermal release, this multifunctional nanosystem is a promising candidate for anticancer therapy.
Counteracting consumer subversion: Organizational privacy ethical care as driver of online information sharing
Authors: Mattison Thompson Frauke , Siamagka Nikoletta‐Theofania 
Published: August 2021

AbstractWith an ever‐increasing hunger for consumer data by firms, and despite many organizational efforts to reduce consumer privacy concerns, consumer subversion behavior towards information provision persists. Organizational privacy ethical care, an organizational behavior that goes beyond legislative action and moral codes, provides a new theory of how to overcome this issue. Across three studies, we develop and test theory which suggests an organizational ethic of care approach to privacy will have a positive impact on reducing consumer subversion behavior (i.e. increase consumers' willingness to share information and the accuracy of information they share). The correlational and causal results indicate that perceived organizational privacy ethical care is a positive driver of the amount and the accuracy of information consumers are willing to share with firms. The results also suggest partial support that this relationship is mediated through perceived information control and trust towards the organization. Thus, we provide some support for a better corporate approach to privacy, beyond previously suggested legislative and social responsibility standards, which allows for the reduction of consumer privacy concerns and subsequent subversion behaviors.