bluuebunny/crossref_metadata_2025_split huggingface dataset:
Memaknai Unsur Naratif Dalam Film Parasite Melalui Perspektif Filsafat Kebebasan Manusia
Authors: Dhia Rifqi Nadhmy , Kurniawan Firman 
Published: June 2021

Human beings essentially have social freedom inherent in themselves. Parasite (2019), a film which raises social issues in South Korea, has a close relationship with the reality of social stratification in society. Using the film Parasite as a case study, this article attempts to trace the tendency of meaning production regarding the philosophy of human freedom. In the process, this article draws the conclusion that the depiction of a person within the social structure in the narrative element of the Parasite film can represent the meaning of social freedom which is also limited by other human freedoms.
Keywords: Communication; Philosophy; Social Freedom; Social Structure; Parasite
Eksplorasi Material Alternatif dalam Pembuatan Puppet dan Set untuk Produksi Animasi Stop-Motion Berjudul “Junk Food”
Authors: Purwaningsih Dominika Anggraeni 
Published: June 2021

Traditional stop-motion animated films have unique visual characteristics so that they have many fans, but the number of stop-motion filmmakers is actually very minimal. This is understandable because compared to other animation techniques that are done digitally, stop-motion seems impractical because it requires longer time, higher production costs, and more tools and materials. This paper discusses the exploration and utilization of alternative materials from well-known conventional materials in making puppets and sets for stop-motion animation. The alternative materials in question will use used goods, household inorganic waste, and other reusable materials while still paying attention to function and aesthetics so as to contribute to waste recycling. This is in line with the theme of the film “Junk Food” which raises the issue of environmental pollution, where the results of this research will be applied. This qualitative research is project-based and uses literature study, observation, and experiment methods to collect data. The results of this research are up to the stage of making 2 puppets and 2 sets to answer the problem of exploring alternative materials from used goods.
Keywords: stop-motion animation, puppet, set, alternative materials
Clustering Alzheimer’s Disease Gene Expression Dataset Reveals Underlying Sexually Dimorphic and Disease Status Profiles
Authors: Levy Sigal , Guttmann-Beck Nili , Shweiki Dorit 
Published: June 2021

Background: The multiple appearance phenotypes in Alzheimer’s disease (AD) are manifested in epidemiologic sexual dimorphism, variation in age of onset, progress, and severity of the disease. Objective: In this study, we focused on sexual dimorphism, aiming to untie some of the complex interconnections in AD between sex, disease status, and gene expression profiles. Two strategic decisions guided our study: 1) to value transcriptomic multi-layered profiles over alterations in single genes expression; and 2) to embrace a sexual dimorphism centered approach, as we suspect that transcriptomic profiles may dramatically differ not only between healthy and sick individuals but between men and women as well. Methods: Microarray dataset GSE15222, fulfilling our strict criteria, was retrieved from the GEO repository. We performed cluster analysis for each sex separately, comparing the proportion of healthy and AD individuals in each cluster. Results: We were able to identify a biased, female, AD-typified cluster. Furthermore, we showed that this female AD-typified cluster is highly similar to one of the male clusters. While the female cluster constitutes mostly sick individuals, the male cluster constitutes healthy and sick individuals in almost identical proportion. Conclusion: Our results clearly indicate that similar transcriptomic profiles in the two sexes are “physiologically translated” in to a very different, dramatic outcome. Thus, our results suggest the need for a sex-based and transcriptomic profile-based study, for a better understanding of the onset and progression of AD.
Temporomandibular joint reconstruction with vascularized free fibula flap following disarticulation resections: A protocol for a systematic review
Authors: Abdelrehem Ahmed 
Published: June 2021

ABSTRACT

BACKGROUND: Mandible reconstruction using vascularized free fibula flaps (FFF) is now considered the state of the art, however, those including disarticulation resections and hence reconstruction of the temporomandibular joint (TMJ) are still challenging for most maxillofacial surgeons as the available literature reports are scarce. Most reports focused on the clinical outcomes, and few focused on the spatial deviations of the neocondyle. Several modifications and methods have been reported to support the fibula and improve the functional outcomes of the TMJ.

OBJECTIVE: The aim of this systematic review is to investigate different functional and morphological outcomes following TMJ reconstruction with FFF after disarticulation resections and correlates with the different modification and factors.

MATERIALS AND METHODS: An online search will be done to check all articles reporting TMJ reconstruction using FFF and advocating different outcomes. prospective clinical study was to introduce three modified techniques simultaneously with mandible reconstruction of the TMJ with vascularized free fibula flap (FFF) for dynamic mandible reconstruction and evaluate the different outcomes of such modifications in comparison to the conventional technique.
Penyuluhan Kebiasaan Hidup Sehat Selama Masa Pandemi COVID-19 dan Pelatihan Pembuatan Sediaan untuk Mencuci
Authors: Purwaniati Purwaniati , Fransiska Denni , Marpaung Helena , Emawati Emma , Fajarwati Kania 
Published: June 2021

Pandemi COVID-19 masih berlangsung hingga kini. Hal ini “memaksa” seluruh masyarakat untuk menerapkan new normal dalam kehidupan sehari-hari. Kebiasaan mencuci tangan dengan sabun dibawah air mengalir atau menggunakan hand sanitizer, menggunakan masker di area publik dan social distancing, menjadi keharusan dalam kehidupan masyarakat saat ini. Kegiatan pengabdian masyarakat ini dilakukan sebagai upaya mengedukasi masyarakat berkenaan dengan new normal tersebut. Kegiatan ini juga ditujukan sebagai upaya peningkatan kemandirian masyarakat dalam pemenuhan produk untuk mencuci yang sangat diperlukan oleh setiap rumah tangga. Rangkaian kegiatan yang dilakukan pada bulan September-Oktober 2020 ini terdiri dari: sosialiasi, pretest, penyuluhan (edukasi) protokol kesehatan pandemi COVID-19, pelatihan pembuatan sediaan untuk mencuci, post-test dan penutupan. Pelatihan pembuatan sediaan untuk mencuci meliputi: pembuatan deterjen cair, pelembut pakaian dan sabun cuci tangan. Dengan pelatihan tersebut masyarakat secara individu atau berkelompok selanjutnya dapat memproduksi sendiri sediaan untuk mencuci untuk memenuhi kebutuhan sehari-hari mereka. Berdasarkan hasil pretest-post-test kegiatan ini terbukti meningkatkan pengetahuan masyarakat mitra. Masyarakat mitra juga sangat terbantu dan berterima kasih atas terselenggaranya kegiatan ini.
Pengembangan Potensi Lokal Desa Krosok Kecamatan Sendang Tulungagung melalui Kuliah Kerja Nyata
Authors: Idris Ahmad , Adi Bagus Prasetyo , Yuliantikasari Wressita 
Published: June 2021

Potensi lokal desa Krosok adalah sektor pertanian dan peternakan dan memiliki alam yang luas dan masih terjaga.Tujuan kegiatan pengabdian masyarakat di desa Krosok adalah memberikan edukasi kepada masyarakat bagaimana mengelola sektor pertanian dan peternakan menggunakan cara-cara yang modern. Kegiatan ini berupa Kuliah Kerja Nyata (KKN) yang dilakukan oleh mahasiswa Universitas Islam Kadiri selama satu bulan mulai tanggal 1 Agustus 2017 sampai 5 September 2017. Kegiatan KKN terdiri dari 2 kegiatan utama yaitu pertama kegiatan edukasi dan kedua kegiatan partisipasi pembangunan sarana prasarana desa. Beberapa kegiatan yang telah dilakukan seperti pembuatan silase dari hijauan ternak, pengembangan pestisida nabati dan mikroorganisme lokal untuk pertanian yang ramah lingkungan, pengembangan UMKM dan etika dalam berbisnis, serta penataan arsip atau dokumen keluarga. Kegiatan berjalan baik dengan dukungan pemerintah desa. Kemudian melihat sumber daya alam yang melimpah memunculkan ide untuk menciptakan desa agrowisata di desa Krosok meskipun hal tersebut belum bisa terealisasi. Akan tetapi dengan adanya kegiatan ini memberi dorongan kepada masyarakat untuk mulai memikirkannya.
LOW BACK PAIN AND ITS ASSOCIATED FACTORS AMONG SECONDARY SCHOOL TEACHERS IN CUTTACK, ODISHA: A CROSS-SECTIONAL STUDY
Authors: Behera Swatisuman , Koley Shyamal 
Published: June 2021

The purpose of the present study was to search the prevalence of low back pain and its associated factors in secondary school teachers of Cuttack, Odisha. For this purpose, 457 secondary school’s teachers aged 26-60 years were contacted from various schools of Cuttack city, of those 191 teachers (76 male and 115 female) were confirmed for low back pain by self- informative questionnaire. Modified Oswestry Low Back Pain Disability Pain Questionnaire and a self-constructed questionnaire were applied to measure the socio-demographic and economic characteristics of the participants. The results revealed that the overall prevalence of LBP in the last 12 months among secondary school teachers was 41.79%, of those female teachers (60.20%) were affected more than their male counterparts. Some factors, such as excessive work load, sleeping disturbance (especially in female teachers), prolonged standing in classroom, physical inactivity affected adversely towards their health and wellbeing causing LBP in them. It was also found that the maximum male (75.00%) and female (58.26%) teachers had the minimum disability in Oswestry Disability Index category. It might be concluded that the addressing work-related and individual factors would be essential to decrease the magnitude of the problem.
Keywords: Low back pain, Prevalence, Associated factors, Secondary school teachers of Cuttack, Odisha.
Analysis of the relationship between temporomandibular dysfunction and sleep quality: A cross-sectional study
Authors: Santos Edilaine Soares , Prates Antônio Marcos de Souza , Barros Fabiele Perpétua Chagas Sabatim , Lima Rachel Silva , Moraes Karolina Nunes Freitas , Hadad Henrique , Lima Valthierre Nunes de , Nogueira Lamis Meorin 
Published: June 2021

Considered as a set of disorders, temporomandibular disorder (TMD) involves several anatomical structures such as the temporomandibular joint, masticatory muscles and attached structures. Its etiology is multifactorial, and the psychobehavioral factor, especially sleep disorders, is relevant in this context. This study aimed to assess the prevalence of temporomandibular dysfunction (TMD), sleep quality, and possible associations between these variables, in first to fifth year students of the Dental School. A sample of 182 students participated in this study and a questionnaire proposed by the American Academy of Orofacial Pain and the Pittsburgh Sleep Quality Index questionnaire were used to obtain the data. 75.27% of the students were females and 24.72% males. TMD was observed in 45.60% of students, and 68.13% of the students reported poor sleep quality. However, there was no significant association between the variables (TMD and sleep quality, p=0.114). Regarding the severity of TMD, the mild form was more prevalent (34.61%), being more prevalent in females (79.16%). However, there was no significant association between TMD and sleep quality (p=0.317). There was no association between TMD and sleep quality in the studied population.
O papel da vitamina D na imunidade e na infecção por coronavírus: Uma revisão da literatura
Authors: Quemel Gleicy Kelly China , Sozinho Marinalva Tavares , Costa José Alberto Paiva da , Marinho Cibelly Lima , Quemel Glenda Keyla China , Moreira Danilo Reymão , Santos Gabriel Cardoso de Queiroz 
Published: June 2021

A vitamina D (VD) é um pré-hormônio e desempenha várias funções: regulador do desenvolvimento ósseo, apresenta atividades antivirais, antifibrótica, imunomoduladora, e de acordo com estudos pode ser capaz de reduzir o risco de morte na infecção por coronavírus, vírus que foi identificado primeiramente em Wuhan (China) em dezembro de 2019 e espalhou-se rapidamente pelo mundo. Dessa forma, o objetivo desta revisão integrativa é conhecer o que a literatura mundial tem publicado acerca da importância clínica da VD na prevenção da infecção por coronavírus. Para a busca dos artigos foram utilizados os descritores, contidos nos DeCs,: [vitamina D/Vitamin D ], [imunidade/ immunity] e [infecção por coronavírus/ coronavirus infections], consultados na base de dados Medline. Os critérios de inclusão foram: artigos completos, disponíveis nos idiomas português e inglês publicados entre 2011 a 04/2021. Foram selecionados trinta artigos no idioma inglês, em que cerca de 36,4% (11) discorrem sobre os fatores que influenciam os níveis séricos da VD organismo e suas implicações na infecção por coronavírus, e 63,3% (19) abordam os mecanismos de ação da VD no sistema imunológico em relação à infecção por coronavírus. Sabe-se que a VD modula a função de células imunes, em uma interação sistema imune inato-adaptativo, regula a expressão e secreção de citocinas, portanto, a intervenção terapêutica com VD pode prevenir e tratar essa doença, impedindo que casos leves se tornem graves. Portanto, a suplementação seria a ferramenta terapêutica efetiva para contrapor a deficiência de VD, mas são necessários mais estudos clínicos para efetivamente comprovar a sua eficácia.
A importância da avaliação da composição da qualidade do pirarucu durante o processamento pós colheita
Authors: Santos Sara Samara Ferreira , Moraes Vanessa Vieira , Azevedo Zoneide Gomes , Ferreira José Carlos de Sales 
Published: June 2021

Introdução: o pirarucu é uma espécie nativo da amazônica, pertencente à ordem Osteoglossiformes, Arapaimidae. É um peixe com elevada importância econômica e um interesse comercial bastante crescente, devido suas características propícias para cultivo, tais como: a alta taxa de crescimento (até 10 kg no primeiro ano), elevada rusticidade ao manuseio, adaptabilidade à alimentação artificial e elevado aproveitamento da carcaça (51-57%). Objetivo: O estudo parte de um levantamento bibliográfico acerca de artigos sobre alterações da qualidade microbiológica pós-colheita do pirarucu. Metodologia: Trata-se de uma pesquisa de revisão bibliográfica, descritiva. Resultado e Discussões: é indispensável o uso frequente de Boas Práticas de Manipulação, APPCC (Análise de Perigos e Pontos Críticos de Controle) para que haja sempre pescados com qualidade e seguros. É necessário manusear com cuidado a carne do pescado no processo de produção para não correr risco de contaminação. Estudos comprovam que a combinação da textura, aparência e sabor nos alimentos é fortemente essencial para a aceitação dos consumidores, para o controle de qualidade dos alimentos o conhecimento da composição dos alimentos no Brasil é fundamental. Conclusão: O pirarucu é um pescado de elevado valor cultural e comercial. O conhecimento dos fatores envolvidos (físico-químicos, microbiológicos e sensoriais) na progressão da deterioração é fundamental para a segurança alimentar aos consumidores finais e para protocolos de beneficiamento e armazenamento ideal nas indústrias.
SIRT6 Promotes Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells Through Antagonizing DNMT1
Authors: Jia Bo , Chen Jun , Wang Qin , Sun Xiang , Han Jiusong , Guastaldi Fernando , Xiang Shijian , Ye Qingsong , He Yan 
Published: June 2021

BackgroundAdipose-derived stem cells (ADSCs) are increasingly used in regenerative medicine because of their potential to differentiate into multiple cell types, including osteogenic lineages. Sirtuin protein 6 (SIRT6) is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase that plays important roles in cell differentiation. NOTCH signaling has also been reported to involve in osteogenic differentiation. However, the function of SIRT6 in osteogenic differentiation of ADSCs and its relation to the NOTCH signaling pathways are yet to be explored.MethodsThe in vitro study with human ADSCs (hADSCs) and in vivo experiments with nude mice have been performed. Alkaline phosphatase (ALP) assays and ALP staining were used to detect osteogenic activity. Alizarin Red staining was performed to detect calcium deposition induced by osteogenic differentiation of ADSCs. Western blot, RT-qPCR, luciferase reporter assay, and co-immunoprecipitation assay were applied to explore the relationship between of SIRT6, DNA methyltransferases (DNMTs) and NOTCHs.ResultsSIRT6 promoted ALP activity, enhanced mineralization and upregulated expression of osteogenic-related genes of hADSCs in vitro and in vivo. Further mechanistic studies showed that SIRT6 deacetylated DNMT1, leading to its unstability at protein level. The decreased expression of DNMT1 prevented the abnormal DNA methylation of NOTCH1 and NOTCH2, resulting in the upregulation of their transcription. SIRT6 overexpression partially suppressed the abnormal DNA methylation of NOTCH1 and NOTCH2 by antagonizing DNMT1, leading to an increased capacity of ADSCs for their osteogenic differentiation.ConclusionThis study demonstrates that SIRT6 physical interacts with the DNMT1 protein, deacetylating and destabilizing DNMT1 protein, leading to the activation of NOTCH1 and NOTCH2, Which in turn promotes the osteogenic differentiation of ADSCs.
Empagliflozin in Patients With Heart Failure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Pan Deng , Xu Lin , Chen Pengfei , Jiang Huiping , Shi Dazhuo , Guo Ming 
Published: June 2021

Purpose: The purpose of the study is to evaluate the effect of empagliflozin in patients with heart failure (HF).Method: We performed a systematic search of PubMed, EMBASE, and the Cochrane Library database through January 20, 2021. Randomized controlled trials (RCTs) were included that compared empagliflozin and placebo in patients with HF. Dichotomous variables were expressed as risk ratios (RRs) with 95% confidence intervals (CIs). Continuous variables were calculated and expressed as mean differences (MD) and standard deviation (SD). Meta-analysis was conducted using a random-effects model on outcomes with high heterogeneity.Results: Seven studies were included in our meta-analysis (n = 5,150). Significant differences were observed in a composite of cardiovascular death or hospitalization for worsening heart failure [RR: 0.77 (95% CI 0.68–0.87); I2 = 18%; P &lt; 0.0001), hospitalization for worsening heart failure [RR: 0.71 (95% CI 0.61–0.82); I2 = 0%; P &lt; 0.00001], changes in Kansas City Cardiomyopathy Questionnaire (KCCQ) score [MD: 1.70 (95% CI 1.67–1.73); I2 = 0%; P &lt; 0.00001], and changes in body weight [MD: −1.43 (95% CI −2.15 to −0.72); I2 = 84%; P &lt; 0.0001) from baseline. However, empagliflozin did not show a better change in the 6-min walk test (6MWT) [MD: 34.06 (95% CI −29.75–97.88); I2 = 97%; P = 0.30] or NT-proBNP [MD: −98.36 (95% CI, −225.83–29.11); I2 = 68%; P = 0.13] from baseline.Conclusion: The findings suggest that empagliflozin was effective in reducing a composite of cardiovascular death or hospitalization for worsening heart failure. Further well-designed RCTs are needed to evaluate the long-term effect of empagliflozin in patients with HF.PROSPERO: CRD42021231712.
Case Report: Liraglutide for Weight Management in Beckwith-Wiedemann Syndromic Obesity
Authors: Caputo Marina , Daffara Tommaso , Bellone Simonetta , Mancioppi Valentina , Marzullo Paolo , Aimaretti Gianluca , Prodam Flavia 
Published: June 2021

Genetic obesity, including syndromic and non-syndromic forms, represents a minority of cases compared to essential obesity but gene dysregulations lead to complex clinical conditions that make their management particularly difficult. Among them, Beckwith-Wiedemann syndrome (BWS) is a multisystem human genomic imprinting disorder characterized by overgrowth. We describe the first case of liraglutide treatment in an 18-year-old boy patient affected by BWS complicated by macroglossia, cryptorchidism, nephroblastoma, organomegaly, microscopic lymphocytic colitis, pharmacologically treated arterial hypertension, obesity, and obstructive sleep apnea syndrome. He presented a normal cognitive development. Body mass index at the time of first transition visit in the adult endocrinology department at the age of 18-years-old was 40.6 kg/m2 without glucose metabolism impairment. Lifestyle interventions failed because of poor compliance. During 20 months of 3.0 mg liraglutide treatment, a weight loss of 19 kg (−13.3%) and BMI reduction of 6.8 points were registered without side effects. To date, liraglutide treatment was effective on obesity in 7 subjects with Prader Willy Syndrome and 14 with melanocortin-4 receptor mutations. The efficacy of liraglutide in BWS could be related to a crosstalk among glucagon-like peptide (GLP)-1 system, mechanisms related to the cyclin-dependent kinase inhibitor 1C (CDKN1C), and dopamine mesolimbic circuit. Clinical trials aiming at a tailored medicine in genetic obesity are needed.
Low-Load Unilateral and Bilateral Resistance Training to Restore Lower Limb Function in the Early Rehabilitation After Total Knee Arthroplasty: A Randomized Active-Controlled Clinical Trial
Authors: Jacksteit Robert , Stöckel Tino , Behrens Martin , Feldhege Frank , Bergschmidt Philipp , Bader Rainer , Mittelmeier Wolfram , Skripitz Ralf , Mau-Moeller Anett 
Published: June 2021

Background: Continuous passive motion (CPM) is frequently used during rehabilitation following total knee arthroplasty (TKA). Low-load resistance training (LLRT) using continuous active motion (CAM) devices is a promising alternative. We investigated the effectiveness of CPM compared to LLRT using the affected leg (CAMuni) and both legs (CAMbi) in the early post-operative rehabilitation. Hypotheses: (I) LLRT (CAMuni and CAMbi) is superior to CPM, (II) additional training of the unaffected leg (CAMbi) is more effective than unilateral training (CAMuni).Materials and Methods: Eighty-five TKA patients were randomly assigned to three groups, respectively: (i) unilateral CPM of the operated leg; (ii) unilateral CAM of the operated leg (CAMuni); (iii) bilateral alternating CAM (CAMbi). Patients were assessed 1 day before TKA (pre-test), 1 day before discharge (post-test), and 3 months post-operatively (follow-up). Primary outcome: active knee flexion range of motion (ROMFlex). Secondary outcomes: active knee extension ROM (ROMExt), swelling, pain, C-reactive protein, quality of life (Qol), physical activity, timed-up-and-go performance, stair-climbing performance, quadriceps muscle strength. Analyses of covariances were performed (modified intention-to-treat and per-protocol).Results: Hypothesis I: Primary outcome: CAMbi resulted in a higher ROMFlex of 9.0° (95%CI −18.03–0.04°, d = 0.76) and 6.3° (95%CI −14.31–0.99°, d = 0.61) compared to CPM at post-test and follow-up, respectively. Secondary outcomes: At post-test, C-reactive protein was lower in both CAM groups compared with CPM. Knee pain was lower in CAMuni compared to CPM. Improved ROMExt, reduced swelling, better stair-climbing and timed-up-and-go performance were observed for CAMbi compared to CPM. At follow-up, both CAM groups reported higher Qol and CAMbi showed a better timed-up-and-go performance. Hypothesis II: Primary outcome: CAMbi resulted in a higher knee ROMFlex of 6.5° (95%CI −2.16–15.21°, d = 0.56) compared to CAMuni at post-test. Secondary outcomes: At post-test, improved ROMExt, reduced swelling, and better timed-up-and-go performance were observed in CAMbi compared to CAMuni.Conclusions: Additional LLRT of the unaffected leg (CAMbi) seems to be more effective for recovery of function than training of the affected leg only (CAMuni), which may be mediated by positive transfer effects from the unaffected to the affected limb (cross education) and/or preserved neuromuscular function of the trained, unaffected leg.Trial Registration:ClinicalTrials.gov Identifier: NCT02062138.