bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relaxation Effect of Extract Ethanol Curcuma Longa on Isolated Guine Pig Trachea
Authors: Yanita Hidayati , Ginting Chrismis Novalinda , Chiuman Linda , Ferdinand Sahna 
Published: December 2021

Aims: Asthma is a chronic obstructive pulmonary disease which is a world health problem that is not only infected in developed countries but also in developing countries. According to the National Asthma Education and Prevention Program (NAEPP), asthma can be defined as a chronic inflammatory disorder that occurs in the airways, which involves inflammatory cells. curcumin reduces allergic airway inflammation in mice through inhibition of a specific pathway aimed at investigating the anti-inflammatory effect of curcumin in acute allergic asthma and its underlying mechanisms in mice.
Study Design: This study is experimental study.
Methodology: The experimental animals were divided into 2 groups, each group consisting of 4 animals. Group 1 gave theophline as a positive control group and group 2 was given extracts with concentrations (1 mg / ml, 2 mg / ml, 3 mg / ml, 4 mg / ml, 5 mg / ml, 6 mg / ml, 7 mg / ml and 8 mg / ml). These animals are acclimatized for 1 (one) week with the aim of homogenizing their food and life with the same conditions so that they are considered eligible for research.
Results: The ethanol extract of curcuma longa has no different ability from atropine sulfate 1 x 10-6 M in reducing the smooth muscle contraction of isolated guinea pig tracheal induced by acetylcholine, the strength of acetylcholine without incubation contraction compared to acetylcholine with EETH incubation showed statistically different results (p<0.05).
Conclusion: The mechanism of the relaxing effect of curcuma longa on isolated mouse smooth muscle is mediated through inhibition of the PDE enzyme.
Multicolor Transparent‐Conductive‐Electrode Free Electronic Paper based on Steel Foil and Water Electrolyte with pH Indicator Dyes
Authors: Rozman Martin 
Published: December 2021

AbstractElectronic paper devices, also known as electrochromic devices, are known for their ability to change color and remain in a particular color state even after the electric power is turned off. Traditional devices such as electrochromic windows use mechanisms such as electrophoresis or intercalation and use special materials such as anhydrous electrolytes and transparent conductive materials (TCMs). As a result, these devices can sometimes be relatively difficult to assemble, especially in developing countries where such materials are difficult to obtain. Recently, some improvements are made by using alternative electrode positioning that do not require TCM. Here, a novel multicolor display module that is recyclable, can be fabricated from readily available materials, and can be scaled according to the desired screen size is presented. The presented device is a semi‐open electrochemical device that uses pH indicator dyes and an aqueous electrolyte solution in combination with readily available stainless steel sheet.
Weather permitting: Increased seasonal efficiency of nonshivering thermogenesis through brown adipose tissue activation in the winter
Authors: Niclou Alexandra , Ocobock Cara 
Published: December 2021

AbstractObjectivesWe investigated seasonal changes in brown adipose tissue (BAT) activation and metabolism in a temperate‐climate Albany, NY population.MethodsData were collected among 58 participants (21 males, 37 females, ages: 18–51) in the summer and 59 participants (23 males, 36 females, ages: 18–63) in the winter in Albany, New York. BAT activity was inferred by comparing metabolic rate, heat dissipation in the supraclavicular area, and respiratory quotient at room temperature and cold exposure. Seasonal variation in BAT was determined by comparing these measurements from summer and winter.ResultsAt mild cold exposure, heat dissipation of the supraclavicular area was significantly greater in the winter compared to summer (p < .001); however, no significant differences were found between seasons in metabolic rate measurements. This suggests BAT activation may be metabolically more efficient in the winter, due to prolonged lower seasonal temperatures relative to summer. Respiratory quotient significantly increased upon mild cold exposure in the winter compared to summer (p < .001). While carbohydrate utilization increased in the winter, fat remained the primary metabolic substrate for BAT activity across both seasons.ConclusionThe seasonal variations in the effects of nonshivering thermogenesis on metabolic rate and substrate metabolism suggest a buffering of energy expenditure and an increased use of glucose as fuel by BAT as a result of acclimatization to cold in the winter. These findings point towards a potential role of BAT in human whole‐body mediated glucose disposal and cold adaptation.
A lipidomic approach for profiling and distinguishing seed oils of Hibiscus manihot L., flaxseed, and oil sunflower
Authors: Yang Feiyun , Zhang Bao , Chen Baiting , Yang Nafei , Wang Ruigang , Zhang Xiujuan , Li Guojing 
Published: December 2021

AbstractAs important oil crops in Inner Mongolia, sunflower, and flaxseed had distinct lipid profiles in seeds. As an emerging cash crop, Hibiscus manihot L. has strong potential market competitiveness. In this study, the lipidome, fatty acid composition and quality characteristics of flaxseed, H. manihot L., and sunflower seed oils were analyzed and compared. A total of 270 distinct lipids were identified and analyzed with an emerging detection approach—lipidomics, which illustrated the tremendous difference among the samples. triacylglycerol, diacylglycerol and polar lipids were the most abundant lipids in all samples. H. manihot L. seeds contained higher saturated and monounsaturated fatty acids and lower polyunsaturated fatty acids. H. manihot L. seed oil had the longest oxidative stability index time, high content of vitamin E and total phenolics, while flaxseed oil embodied the lowest oxidative stability. The peroxide value and acid value of the three oils were within the allowable range of Chinese national standards.
Governance networks in the delivery of public healthcare services in the Pacific: Implementation of the Bougainville Healthy Communities Programme
Authors: Ugyel Lhawang 
Published: December 2021

AbstractNetworks play a vital role in the delivery of public services, especially in countries where governments are constrained by capacity and funds. This study develops a framework of governance networks based on two dimensions: at the national and community levels, and within the governmental and non‐governmental sectors. Based on the framework, this article analyses the governance networks of the Bougainville Healthy Communities Programme (BHCP) and their nature of integration and collaboration. BHCP mainly operates as a public healthcare advocacy program in Bougainville, an underdeveloped autonomous region of Papua New Guinea. BHCP’s success reveals that the nature of interaction among the various actors is key to making governance networks work. Its experience demonstrates that governance networks are important in the effective delivery of services, particularly in countries where the governments face financial and human resources shortages.
Impact of Cytokine Inhibitor Therapy on the Prevalence, Seroconversion Rate, and Longevity of the Humoral Immune Response Against SARS–CoV‐2 in an Unvaccinated Cohort
Authors: Simon David , Tascilar Koray , Kleyer Arnd , Fagni Filippo , Krönke Gerhard , Meder Christine , Dietrich Peter , Orlemann Till , Kliem Thorsten , Mößner Johanna , Liphardt Anna‐Maria , Schönau Verena , Bohr Daniela , Schuster Louis , Hartmann Fabian , Leppkes Moritz , Ramming Andreas , Pachowsky Milena , Schuch Florian , Ronneberger Monika , Kleinert Stefan , Hueber Axel J. , Manger Karin , Manger Bernhard , Atreya Raja , Berking Carola , Sticherling Michael , Neurath Markus F. , Schett Georg 
Published: December 2021

ObjectiveTo investigate the impact of biologic disease‐modifying antirheumatic drug (bDMARD) treatment on the prevalence, seroconversion rate, and longevity of the humoral immune response against SARS–CoV‐2 in patients with immune‐mediated inflammatory diseases (IMIDs).MethodsAnti–SARS–CoV‐2 IgG antibodies were measured in a prospective cohort of health care professional controls and non–health care controls and IMID patients receiving no treatment or receiving treatment with conventional or biologic DMARDs during the first and second COVID‐19 waves. Regression models adjusting for age, sex, sampling time, and exposure risk behavior were used to calculate relative risks (RRs) of seropositivity. Seroconversion rates were assessed in participants with polymerase chain reaction (PCR)–positive SARS–CoV‐2 infection. Antibody response longevity was evaluated by reassessing participants who tested positive during the first wave.ResultsIn this study, 4,508 participants (2,869 IMID patients and 1,639 controls) were analyzed. The unadjusted RR (0.44 [95% confidence interval (95% CI) 0.31–0.62]) and adjusted RR (0.50 [95% CI 0.34–0.73]) for SARS–CoV‐2 IgG antibodies were significantly lower in IMID patients treated with bDMARDs compared to non–health care controls (P < 0.001), primarily driven by treatment with tumor necrosis factor inhibitors, interleukin‐17 (IL‐17) inhibitors, and IL‐23 inhibitors. Adjusted RRs for untreated IMID patients (1.12 [95% CI 0.75–1.67]) and IMID patients receiving conventional synthetic DMARDs (0.70 [95% CI 0.45–1.08]) were not significantly different from non–health care controls. Lack of seroconversion in PCR‐positive participants was more common among bDMARD‐treated patients (38.7%) than in non–health care controls (16%). Overall, 44% of positive participants lost SARS–CoV‐2 antibodies by follow‐up, with higher rates in IMID patients treated with bDMARDs (RR 2.86 [95% CI 1.43–5.74]).ConclusionIMID patients treated with bDMARDs have a lower prevalence of SARS–CoV‐2 antibodies, seroconvert less frequently after SARS–CoV‐2 infection, and may exhibit a reduced longevity of their humoral immune response.
Association of placental pathology and gross morphology with autism spectrum disorders
Authors: Soullane Safiya , Spence Andrea R. , Abenhaim Haim A. 
Published: December 2021

AbstractThis study evaluated the association between placental pathology and gross morphology and the risk of autism spectrum disorders (ASD). We conducted a matched case–control study of children with confirmed ASD who were born between 2000 and 2017 at one of three university‐affiliated hospitals in Montreal, Quebec. Cases, who were identified through the Montreal Children's Hospital Autism Spectrum Disorders Program, were matched to babies (1:5) born at the same hospital and on the same day. Multi‐fetal births were excluded. Maternal demographics, pregnancy characteristics and placental pathologies were collected from hospital charts by abstractors blind to autism diagnoses. This current study consisted of data from a single‐site that had pathology reports available. Pearson chi‐square and Wilcoxon rank‐sum tests were used to estimate p‐values. Our study consisted of 107 ASD cases and 526 matched controls. Mothers of cases and controls were similar in terms of parity, gravidity, smoking status, BMI, rates of clinical chorioamnionitis, chronic hypertension, and gestational diabetes. Age at delivery of <25 years was more common among mothers of controls. Compared with controls, cases were more likely born male, <32 weeks of gestation, and weighing <1500 g. Cases and controls had similar rates of placental inflammation, vasculitis, and other placental pathologies. There were no differences in placental weight, placental thickness, umbilical cord length, and umbilical cord insertion between the two groups. In conclusion, placental pathology and gross morphology do not appear to be associated with ASD, suggesting that any perinatal determinants of autism are not likely to be mediated through placental pathology.Lay SummaryData from a matched case–control study consisting of neonates born between 2000 and 2017 at one of three McGill‐affiliated hospitals were used to examine the relationship between placental pathology and morphology and the development of autism. No differences in placental pathology and gross morphology were found between those with and without autism, which suggests that placental abnormalities are unlikely to either cause or mediate the development of autism.
A preliminary examination of social preference across assessors
Authors: Huntington Rachelle , Schwartz Ilene 
Published: December 2021

AbstractThree assessors conducted paired stimulus preference assessments with an adult with autism spectrum disorder, his mother, a staff member, and an unknown researcher. Results indicated that the participant preferred different social interactions with his mother, as compared to the other assessors. In a follow‐up reinforcer assessment, the social interactions identified as most preferred for each assessor produced higher frequency responding when compared to no consequence or nonmatching preference conditions. Results suggest that preference for social interactions may vary based on the assessor. Implications regarding the impact of the assessor in social preference assessments are discussed.
Knowledge and use of prognostic scales by oncologists and palliative care physicians in adult patients with advanced cancer: A national survey (ONCOPRONO study)
Authors: Dantigny Raphaëlle , Ecarnot Fiona , Economos Guillaume , Perceau‐Chambard Elise , Sanchez Stéphane , Barbaret Cécile 
Published: December 2021

AbstractBackgroundPrognostic scales exist to estimate patient survival in advanced cancer. However, there are no studies evaluating their use and practice. The objective of this study was to evaluate in a nationwide study the proportion of oncologists and palliative care physicians who had knowledge of these scales.MethodsA descriptive, national, cross‐sectional study was conducted via an online questionnaire to oncologists and palliative care physicians across France.ResultsPalliative care physicians had better knowledge of the scales than oncologists (42.3% (n = 74) vs. 27.8% (n = 33), p = 0.015). The Palliative Performance Status (PPS) and Pronopall Scale were the best‐known (51.4% (n = 55) and 65.4% (n = 70), respectively) and the most widely used (35% (n = 28) and 60% (n = 48), respectively). Improved training in the use of these scales was requested by 85.4% (n = 251) of participants, while 72.8% (n = 214) reported that they did not use them at all. Limited training and lack of consensus on which scale to use were cited as the main obstacles to use.ConclusionThis is the first national study on the use of prognostic scales in advanced cancer. Our findings highlight a need to improve training in these scales and to reach a consensus on scale selection.
Proteome analysis of NRF2 inhibition in melanoma reveals CD44 up‐regulation and increased apoptosis resistance upon vemurafenib treatment
Authors: Weitzenböck Hans Peter , Gschwendtner Anna , Wiesner Christoph , Depke Maren , Schmidt Frank , Trautinger Franz , Hengstschläger Markus , Hundsberger Harald , Mikula Mario 
Published: December 2021

AbstractMalignant melanoma is the deadliest form of skin cancer and NRF2 has been proposed as a main regulator of tumor cell malignancy. Still the mechanisms how NRF2 is contributing to melanoma progression are incompletely understood. Here we analyzed the effects of either NRF2 induction or depletion, and we also quantified changes on the whole cell proteome level. Our results showed that inhibition of NRF2 leads to a loss of reactive oxygen species protection, but at the same time to an induction of an epithelial mesenchymal transition (EMT) phenotype and an up‐regulation of the stem cell marker CD44. Additionally, cells devoid of NRF2 showed increased cell viability after treatment with a MYC and a BRAF inhibitor. Importantly, survival upon vemurafenib treatment was dependent on CD44 expression. Finally, analysis of archival melanoma patient samples confirmed a vice versa relationship of NRF2 and CD44 expression. In summary, we recorded changes in the proteome after NRF2 modulation in melanoma cells. Surprisingly, we identified that NRF2 inhibition lead to induction of an EMT phenotype and an increase in survival of cells after apoptosis induction. Therefore, we propose that it is important for future therapies targeting NRF2 to consider blocking EMT promoting pathways in order to achieve efficient tumor therapy.
High‐Energy Aqueous Asymmetric Supercapacitors via Synergistic Design of Electrodes Derived from Hierarchical Vanadium Dioxide Nanocomposites
Authors: He Qichang , Peng Zhongyou , Li Shulong , Tan Licheng , Chen Yiwang 
Published: December 2021

AbstractThe energy density of aqueous asymmetric supercapacitors (ASCs) is confined by the narrow voltage and the mismatching between cathode and anode. Vanadium dioxide (VO2) can contemporaneously operate in both negative and positive potential windows for efficient aqueous ASCs. Nonetheless, their intrinsically inferior cycling stability and capacity seriously restrain the overall capacitive properties. Herein, a novel manganese dioxide (MnO2) coated VO2 (VO2@MnO2) with hierarchical structure is firstly fabricated as cathode with enlarged potential (0 to 1.2 V) and superb specific capacitance (608.9 F g−1 at 1.0 A g−1). Subsequently, VO2 coated by a thin layer of carbon (VO2@C) owning high electric conductivity and superb structure stability is designed to match with VO2@MnO2 cathode. Eventually, the VO2@C//VO2@MnO2 aqueous ASCs exhibit stable voltage (2.2 V), maximal energy density (77.1 Wh kg−1) and favourable cycling stability. This research inspires the design and preparation of matchable electrode materials, providing a feasible method for the development of aqueous ASCs with broad voltage.
Morphology of human ear canal and its effect on sound transmission
Authors: Zhou Lei , Shen Na , Feng Miaolin , Liu Houguang , Duan Maoli , Huang Xinsheng 
Published: December 2021

AbstractThe ear canal (EC) is essential for sound transfer and crucial for hearing. Some pathological conditions may modify its morphology, leading to EC sound pressure redistribution, and stapes footplate displacement (FPD) gain alteration. However, no consensus regarding pathological EC and its impact on sound transfer has yet been achieved. To address the effect of morphology of EC on sound pressure redistribution and FPD gain. Varied pathological EC finite element (FE) models were constructed and analyzed based on FE analysis. The results indicated that canal wall down mastoidectomy decreases the second resonance frequency of the EC. The canal wall down mastoidectomy, with conchaplasty increased the first resonance frequency, but decreased the second along with the interval sound pressure gain increased, following which the FPD gain was altered. Stenosis of the EC at the internal portion decreased the second resonance frequency with minimal effect to the first part. When the stenosis moved to the outer portion of the EC, the first resonance frequency decreased, and the second one increased, along with the interval sound pressure gain decreased and FPD gain. Finally, the simplified EC model exerted a minimal effect on sound transfer. The minimal change in EC, such as simplification, straightening, canal wall down mastoidectomy, or enlargement, moderately affects the sound transfer; however, the EC stenosis deteriorates the sound transfer remarkably.
Dyad integrative behavior and negotiation outcomes
Authors: McGuire Stephen J. J. , Reilly Peter R. , Zhang Yang , Prabhu Veena P. 
Published: December 2021

AbstractThe study's goal was to examine the relationship between dyad integrative behavior and the frequency and quality of negotiated outcomes: achieving a negotiated agreement (“getting to yes”), the quality of the agreement and the parties' satisfaction with the deal reached. We hypothesized that integrative behavior mediated the relationship between dyad personal characteristics and negotiation outcomes after controlling for negotiation skill. Data were collected from 134 MBA dyads. We found that dyad integrative behavior predicted arriving at a negotiated agreement, satisfaction with outcomes and the creativity, practicality, and quality of agreements. Integrative behavior mediated the relationship between dyad personal characteristics (homogeneity in gender, country of origin, conscientiousness, agreeableness, and competing preference) and some negotiation outcomes. In conclusion, as a social exchange, negotiation is largely successful to the extent that negotiators demonstrate behavior that is fair, straightforward and rational. The study contributes to the evidence of the predictive power of dyad integrative behavior on negotiation outcomes.
Variability of the essential oil composition of cultivated populations of Salvia lavandulifolia Vahl
Authors: Sánchez‐Vioque Raúl , Herraiz‐Peñalver David , Melero Bravo Enrique , Ortiz de Elguea‐Culebras Gonzalo , Herrero Baudilio , Santiago Yolanda , Bueno Marta , Pérez‐Magarino Silvia , del Carmen Asensio S. Manzanera María 
Published: December 2021

AbstractSpanish sage or lavender sage (Salvia lavandulifolia Vahl) is an aromatic plant with a high economic potential in agriculture because of its rusticity and low chemical inputs. However, the presence of numerous chemotypes hinders the supply of homogeneous crops to the industry and makes the selection and the standardising of the plant material necessary. With this aim, our group achieved an extensive population survey of this species across the Iberian Peninsula to investigate the variability of this species and started a selection program based in multienvironment trials. Thus, 12 wild populations of S. lavandulifolia have been grown in two different localities and their dry biomass production, yield, and composition of essential oil have been monitored during 2 yr of cultivation to evaluate the effect of the genotype × environment interaction on these traits. Each population presented a clearly differentiated composition of the essential oil, although camphor (15.3% average), 1,8‐cineole (15.0%), α‐pinene (11.3%), β‐pinene (8.5%), and limonene (7.5%) were the main compounds. Other compounds like p‐cymene, γ‐terpinene, bornyl acetate, spathulenol, or viridiflorol were only present in some samples. The yield of essential oil ranged from 0.9 to 2.3 g per 100 g dry biomass, and the dry biomass from 76 to 322 g plant−1. Despite the high variability of these traits, we inferred that the essential oil composition in S. lavandulifolia is chiefly determined by genetics which suggests that individual plants (clones) with a favorable composition for a specific application could be selected and bred with a homogeneous quality over time.