bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local Explosion Detection and Infrasound Localization by Reverse Time Migration Using 3-D Finite-Difference Wave Propagation
Authors: Fee David , Toney Liam , Kim Keehoon , Sanderson Richard W. , Iezzi Alexandra M. , Matoza Robin S. , De Angelis Silvio , Jolly Arthur D. , Lyons John J. , Haney Matthew M. 
Published: February 2021

Infrasound data are routinely used to detect and locate volcanic and other explosions, using both arrays and single sensor networks. However, at local distances (&lt;15 km) topography often complicates acoustic propagation, resulting in inaccurate acoustic travel times leading to biased source locations when assuming straight-line propagation. Here we present a new method, termed Reverse Time Migration-Finite-Difference Time Domain (RTM-FDTD), that integrates numerical modeling into the standard RTM back-projection process. Travel time information is computed across the entire potential source grid via FDTD modeling to incorporate the effects of topography. The waveforms are then back-projected and stacked at each grid point, with the stack maximum corresponding to the likely source. We apply our method to three volcanoes with different network configurations, source-receiver distances, and topography. At Yasur Volcano, Vanuatu, RTM-FDTD locates explosions within ∼20 m of the source and differentiates between multiple vents. RTM-FDTD produces a more accurate location for the two Yasur subcraters than standard RTM and doubles the number of detected events. At Sakurajima Volcano, Japan, RTM-FDTD locates the source within 50 m of the active vent despite notable topographic blocking. The RTM-FDTD location is similar to that from the Time Reversal Mirror method, but is more computationally efficient. Lastly, at Shishaldin Volcano, Alaska, RTM and RTM-FDTD both produce realistic source locations (&lt;50 m) for ground-coupled airwaves recorded on a four-station seismic network. We show that RTM is an effective method to detect and locate infrasonic sources across a variety of scenarios, and by integrating numerical modeling, RTM-FDTD produces more accurate source locations and increases the detection capability.
Common and Rare Variants Genetic Association Analysis of Circulating Neutrophil Extracellular Traps
Authors: Donkel Samantha J. , Portilla Fernández Eliana , Ahmad Shahzad , Rivadeneira Fernando , van Rooij Frank J. A. , Ikram M. Arfan , Leebeek Frank W. G. , de Maat Moniek P. M. , Ghanbari Mohsen 
Published: February 2021

IntroductionNeutrophils contribute to host defense through different mechanisms, including the formation of neutrophil extracellular traps (NETs). The genetic background and underlying mechanisms contributing to NET formation remain unclear.Materials and MethodsWe performed a genome-wide association study (GWAS) and exome-sequencing analysis to identify common and rare genetic variants associated with plasma myeloperoxidase (MPO)-DNA complex levels, a biomarker for NETs, in the population-based Rotterdam Study cohort. GWAS was performed using haplotype reference consortium(HRC)-imputed genotypes of common variants in 3,514 individuals from the first and 2,076 individuals from the second cohort of the Rotterdam Study. We additionally performed exome-sequencing analysis in 960 individuals to investigate rare variants in candidate genes.ResultsThe GWAS yielded suggestive associations (p-value &lt; 5.0 × 10−6) of SNPs annotated to four genes. In the exome-sequencing analysis, a variant in TMPRSS13 gene was significantly associated with MPO-DNA complex levels (p-value &lt; 3.06×10−8). Moreover, gene-based analysis showed ten genes (OR10H1, RP11-461L13.5, RP11-24B19.4, RP11-461L13.3, KHDRBS1, ZNF200, RP11-395I6.1, RP11-696P8.2, RGPD1, AC007036.5) to be associated with MPO-DNA complex levels (p-value between 4.48 × 10−9 and 1.05 × 10−6). Pathway analysis of the identified genes showed their involvement in cellular development, molecular transport, RNA trafficking, cell-to-cell signaling and interaction, cellular growth and proliferation. Cancer was the top disease linked to the NET-associated genes.ConclusionIn this first GWAS and exome-sequencing analysis of NETs levels, we found several genes that were associated with NETs. The precise mechanism of how these genes may contribute to neutrophil function or the formation of NETs remains unclear and should be further investigated in experimental studies.
Combined Immunotherapy With Belatacept and BTLA Overexpression Attenuates Acute Rejection Following Kidney Transplantation
Authors: Zhang Hengcheng , Wang Zijie , Zhang Jiayi , Gui Zeping , Han Zhijian , Tao Jun , Chen Hao , Sun Li , Fei Shuang , Yang Haiwei , Tan Ruoyun , Chandraker Anil , Gu Min 
Published: February 2021

BackgroundCostimulatory blockade provides new therapeutic opportunities for ensuring the long-term survival of kidney grafts. The adoption of the novel immunosuppressant Belatacept has been limited, partly due to concerns regarding higher rates and grades of acute rejection in clinical trials. In this study, we hypothesized that a combined therapy, Belatacept combined with BTLA overexpression, may effectively attenuate acute rejection after kidney transplantation.Materials and MethodsThe rat kidney transplantation model was used to investigate graft rejection in single and combined therapy. Graft function was analyzed by detecting serum creatinine. Pathological staining was used to observe histological changes in grafts. The expression of T cells was observed by immunohistochemistry and flow cytometry.In vitro, we constructed an antigen-stimulated immune response by mixed lymphocyte culture, treated with or without Belatacept and BTLA-overexpression adenovirus, to observe the proliferation of receptor cells and the expression of cytokines. In addition, western blot and qRT-PCR analyses were performed to evaluate the expression of CTLA-4 and BTLA at various time points during the immune response.ResultsIn rat models, combined therapy reduced the serum creatinine levels and prolonged graft survival compared to single therapy and control groups. Mixed acute rejection was shown in the allogeneic group and inhibited by combination treatment. Belatacept reduced the production of DSA and the deposition of C4d in grafts. Belatacept combined with BTLA overexpression downregulated the secretion of IL-2 and IFN-γ, as well as increasing IL-4 and IL-10 expression. We also found that Belatacept combined with BTLA overexpression inhibited the proliferation of spleen lymphocytes. The duration of the elevated expression levels of CTLA-4 and BTLA differentially affected the immune response.ConclusionBelatacept combined with BTLA overexpression attenuated acute rejection after kidney transplantation and prolonged kidney graft survival, which suggests a new approach for the optimization of early immunosuppression after kidney transplantation.
A Cost-Effectiveness Analysis of Systemic Therapy for Metastatic Hormone-Sensitive Prostate Cancer
Authors: Sung Winnie W. Y. , Choi Horace C. W. , Luk Peter H. Y. , So Tsz Him 
Published: February 2021

BackgroundCurrently, approved first-line treatment options of metastatic hormone-sensitive prostate cancer (mHSPC) include (1) androgen deprivation therapy (ADT) alone, ADT plus one of the following: (2) docetaxel, (3) abiraterone, (4) enzalutamide, and (5) apalutamide. The high cost of novel androgen receptor pathway inhibitors warrants an understanding of the combinations’ value by considering both efficacy and cost.ObjectiveThis study aimed to compare the cost-effectiveness of these five treatment options in mHSPC from the US payer perspective to guide treatment sequence.MethodsA Markov model was developed to compare the lifetime cost and effectiveness of these five first-line treatment options for mHSPC using outcomes data from published literature. Health outcomes were measured in life-years and quality-adjusted life-years (QALYs). Drug costs were obtained from the Veterans Affairs Pharmaceutical Catalog. We extrapolated survival beyond closure of the trials.Outcome Measurements and Statistical AnalysisLife-years, QALYs, lifetime costs, and incremental cost-effectiveness ratios (ICERs) were estimated. Univariable, 2-way, and probabilistic sensitivity analyses were performed to evaluate parameter uncertainty. A willingness-to-pay (WTP) threshold of US$100,000 per QALY was used.ResultsCompared to ADT alone, docetaxel plus ADT provided a 0.28 QALY gain at an ICER of US$12,870 per QALY. Abiraterone plus ADT provided an additional 1.70 QALYs against docetaxel plus ADT, with an ICER of US$38,897 per QALY. Compared to abiraterone plus ADT, enzalutamide plus ADT provided an additional 0.87 QALYs at an ICER of US$509,813 per QALY. Apalutamide plus ADT was strongly dominated by enzalutamide plus ADT. Given the WTP threshold of US$100,000 per QALY, abiraterone plus ADT represented high-value health care.ConclusionsAbiraterone plus ADT is the preferred treatment option for men with mHSPC at a WTP threshold of US$100,000 per QALY.
Sex-Based Heterogeneity in the Clinicopathological Characteristics and Prognosis of Breast Cancer: A Population-Based Analysis
Authors: Han Yiqun , Wang Jiayu , Wang Zijing , Xu Binghe 
Published: February 2021

PurposeTo better understand the differences in clinicopathological features and prognosis between male breast cancer (MBC) and female breast cancer (FBC).Material and MethodsData on patients diagnosed with breast cancer from January 1, 2010, to December 31, 2016, were obtained from the Surveillance, Epidemiology, and End Results database. Selected patients were classified into MBC and FBC, of which population demographics and clinicopathological features at baseline were successively extracted for analysis. Comparative analysis was performed to explore the differences in baseline characteristics, followed by propensity-score matching to calibrate the objective distinctions for adjusted analysis. Survival analysis was carried out to investigate divergences presented in prognosis from the two cohorts, and risk factors for prognosis were successively identified using univariate and multivariate COX regression analyses.ResultsA total of 407341 individuals were eligible, including 3111 MBC (0.7%) and 404230 FBC (99.3%) patients. Comparatively, patients with MBC tended to be older at diagnosis, with a higher confirmation of ductal carcinoma, a higher histological grade, a higher TNM stage, a higher proportion of luminal-like subtype, a higher rate of lung metastasis, a lower incidence of liver involvement, and a lower rate of surgical, radiation, and chemotherapeutic delivery. The overall prognosis of MBC was significantly worse than that of FBC, with a decreasing divergence both in median overall survival (65.5 months vs. 72.7 months, P&lt;0.0001) and median breast cancer-specific survival (75.4 months vs. 77.8 months, P&lt;0.0001). However, these discrepancies were not consistent among patients from different subgroups stratified by molecular subtype, age at diagnosis, or disease stage.ConclusionIn this study, sex-based heterogeneity in clinicopathological characteristics and prognostic profiles was observed in the overall population of patients with breast cancer and was significantly variable among different subgroups. A male-specific design with reasonable endpoints for a clinical trial protocol will be warranted in the future.
Dealing With COVID-19 Patients: A Moderated Mediation Model of Exposure to Patients' Death and Mental Health of Italian Health Care Workers
Authors: Portoghese Igor , Galletta Maura , Meloni Federico , Piras Ilenia , Finco Gabriele , D'Aloja Ernesto , Campagna Marcello 
Published: February 2021

Introduction: The COVID-19 pandemic is asking health care workers (HCWs) to meet extraordinary challenges. In turn, HCWs were experiencing tremendous psycho-social crisis as they have had to deal with unexpected emotional requirements (ERs) arising from caring for suffering and dying patients on a daily basis. In that context, recent studies have highlighted how HCWs working during the COVID-19 outbreak manifested extreme emotional and behavioral reactions that may have impacted their mental health, increasing the risk for developing post-traumatic stress symptoms.Purpose: The aim of the study was to investigate post-traumatic stress symptoms, such as intrusion symptoms, as a potential mediator of the link between ERs and crying at work, and whether rumination moderates the relationship between ERs and intrusion-based PTS symptoms among HCWs who have had to deal with patients dying from COVID-19.Methods: An online cross-sectional study design was performed. A total of 543 Italian HCWs (physicians and nurses) participated in the study. Participation was voluntary and anonymous. We used the SPSS version of bootstrap-based PROCESS macro for testing the moderated mediation model.Results: ERs had an indirect effect on crying at work through the mediating role of intrusion symptoms. Results from the moderated mediation model showed that rumination moderated the indirect effect of ERs on crying at work via intrusion symptoms, and this effect was significant only for high rumination. Furthermore, when we tested for an alternative model where rumination moderates the direct effect of ERs on crying at work, this moderation was not significant.Conclusions: As the second wave of the COVID-19 pandemic is ongoing, there is an urgent need for decision-makers to rapidly implement interventions aimed at offering timely psychological support to HCWs, especially in those contexts where the risk of emotional labor associated to patients dying from COVID-19 is higher.
AKSELERASI TINGKAT PENGETAHUAN MAHASISWA TENTANG SISTEM DAN PRODUK PERBANKAN SYARIAH MELALUI MEDIA ONLINE PADA PROGRAM STUDI PERBANKAN SYARIAH UIN ALAUDDIN MAKASAR
Authors: Trimulato Trimulato 
Published: February 2021

Sharia banking in Indonesia continues to experience growth, this can be seen from the total assets of sharia banking which has reached 451,202,000,000,000 in 2018. It's just that the market share of sharia banking has not reached 10 percent, but still around 6 percent. The level of public knowledge and literacy about sharia products is also still minimal. Efforts are needed to increase public knowledge and interest in increasing the use of product of sharia banking. Technological advances can be used as a means to increase knowledge about sharia banking system and product. Students are one element that utilizes technology a lot as a medium of learning, especially in increasing knowledge. This research is a field research, which is obtained data through pre-test and post-test activities to 34 students to provide answers to the questions given. This research is qualitative in nature, with direct data collection techniques to student of departement sharia banking UIN Alauddin Makassar. The analysis technique used is descriptive qualitative related to the level of student knowledge and the use of Google classroom in learning. The results of this study show an increase in student knowledge about sharia banking system and product after pre-test and post-test. The average value increase from 78.4 increased to 86.1. The increase in value reached 9.8 percent. Google classroom can be used as a learning medium in the form of providing materials, learning videos, discussions and quizzes. This media can increase the knowledge of sharia banking for students departement of sharia banking UIN Alauddin Makassar about system and product of sharia banking.
Keywords: Knowledge, System and Product of Sharia Banking, Online Media, and Students Departement of Sharia Banking UIN Alauddin Makassar.
THE EFFECT OF ENVIRONMENT DIMENSIONS OF CONTINGENCY ON BUDGETARY SLACK
Authors: Frihatni Andi Ayu , Abbas Ahmad 
Published: February 2021

This research aims at testing the effect of contingency determinants dimensioned into organizational commitment, budgeting participatory, information asymmetry and environmental uncertainty on the budgetary slack. The sample of this research is sixty governmental internal auditors of BPKP in South Sulawesi. All data were analyzed using path analysis. The results have shown that contingency determinants consisting of organizational commitment, budgeting participatory, information asymmetry, and environmental uncertainty provide positive direct effect on the budgetary slack, otherwise organizational commitment has no indirect effect on the relationship between contingency determinants and the budgetary slack
Narrative Approach To Living Heritage
Authors: Walter Nigel 
Published: February 2021

This paper attempts to sketch out a theoretical framework that addresses the particular needs of living heritage. ICCROM has been at the forefront of developing a conservation practice which addresses the concerns of living heritage such as religious and pilgrimage sites (e.g. Wijesuriya 2015; Wijesuriya, Thompson, and Court 2017), and others have considered the implications for the conservation process (e.g. Poulios 2014). However, to date there has been no attempt to develop a theoretical foundation for these practices. In place of the still-dominant understanding (at least as encountered in much Western practice) of historic buildings as primarily art-historical, this paper proposes a narrative approach that allows the site or building to remain within its cultural/religious context, including an acceptance of ongoing change. While the argument proceeds from Western sources, it invites dialogue with complementary understandings of the working of tradition from other regions of the world.

Any theoretical model for living heritage must address the central question of how living buildings endure between generations, that is, their continuity between past, present and future. Since modernity entails a commitment to a radical discontinuity with the past, such an approach must engage with the resources of premodernity to develop (or perhaps return to) a non-modern understanding of tradition as developmental and creative (Author, 2017). The principal sources used in the investigation of this proposed narrative approach include Alasdair MacIntyre’s rehabilitation of tradition, Hans-Georg Gadamer’s development of philosophical hermeneutics and Paul Ricoeur’s work on narrative and time.
Highly tunable dual bound states in the continuum in bulk Dirac semimetal metasurface
Authors: Ma Changchun , Lin Qi , Wang Lingling , Huang Kai 
Published: February 2021

Abstract
We present a bulk Dirac semimetal (BDS) metasurface to realize tunable dual bound states in the continuums (BICs). The dual polarization-dependent BICs can transform into quasi-BICs with EIT or Fano lineshapes by breaking the structural symmetry. The excitation of quasi-BICs can attribute to the coupling between magnetic quadrupole mode and electric dipole mode (quasi-BIC I), or the coupling of two magnetic quadrupole modes (quasi-BIC II). The BIC resonant wavelength can be dynamically tuned while maintaining the spectral lineshape by varying the Fermi energy of BDS without re-optimizing the geometrical structures, which provides a new route for ultra-compact active BIC device.
Reconfigurable liquid electromagnetic metamaterials driven by magnetic fields
Authors: Xing Xiaochang , Tian Xiaoyong , Jia Xinyu , Li Dichen 
Published: February 2021

Abstract
We propose a reconfigurable electromagnetic metamaterial device driven by magnetic fields. A field-driven reconfigurable metamaterial component (FD-RMC) consisting of periodic channels and compound liquid medium is fabricated. The transition of the electromagnetic metamaterial device from an absorbing state to a frequency-selective state is realized by placing the FD-RMC filled with a compound liquid medium in a gradient magnetic field. The effective bandwidth of the FD-RMC is 14.1 GHz (3.9–18 GHz) in the absorbing state, and it exhibits obvious filtering characteristics at 7.8 GHz in the frequency-selective state. Repeated testing showed that the FD-RMC has great repeatable reconfigurability.
Análisis a la producción científica en auditoría de recursos humanos
Authors: Sánchez Henríquez Jorge Alejandro , Yáñez Vidal Ignacio 
Published: February 2021

El propósito del presente artículo es realizar una revisión de la producción científica relacionada Auditoria de Recursos Humanos en la base de datos de Scielo, ocupando las técnicas que otorga la bibliometría.
Los registros fueron sometidos a un proceso de observación y análisis para posteriormente realizar un estudio bibliométrico de tipo descriptivo, mediante la herramienta MS Excel.
Los datos fueron clasificados por producción científica anual, países, áreas temáticas y por los principales idiomas de los resultados encontrados. También se realiza un análisis referente a las revistas donde se publican los resultados obtenidos y finalmente se realiza una clasificación en cuanto a artículos que poseen un enfoque empírico y teórico.
Se muestra que en este campo de estudio la producción científica en lo referente a la Auditoria de Recursos Humanos es baja, pero que tiene una tendencia al aumento en el futuro y que esta se concentra mayormente en Latinoamérica. También se destaca el predominio de artículos de enfoque empírico por sobre los artículos de enfoque teórico.
Simple , safe and fast Ponseti cast removal procedure in pes equina varus patients
Authors: Dırvar Ferdi , Cengiz Ömer 
Published: February 2021

Objective: In our study, it is aimed to remove the cast more easily and safely without using the cutting tools by leaving the cast ends marked by folding in the idiopathic clubfoot patients treated with Ponseti method.
Material and Methods: Forty feet of 29 patients treated for Pes Equinovarus were included in the study. Patients were followed up in two groups. The group treated with Ponseti method by cast marking were named as “modified group” and cast wrapped group without marking were named as “classical group”. Neurological, teratologic and syndromic clubfoot patients were not included in the study. During the six series of casting, cast removal times for each extremity are recorded in minutes and it is noted that whether any additional cutting tool is used during cast removal or not. A summary of the data was presented as mean, standard deviation and percentage. Comparisons of the categorical characteristics were analysed by using the Chi-square test and the Mann-Whitney test. IBM-SPSS 20 program was used for analysis. In all tests, the level of significance was adjusted to 0.05.
Results: Thirteen (44.8%) of the 29 patients were male and 16 (55.2%) were female. While the mean time to start treatment for the 15 patients in the modified group was 3.46 (2-7) days, mean time for the 14 patients in the classical group was 3.78 (2-10) days. While the mean cast removal time of the 20 extremities of 15 patients in the modifying group was 10.9 minutes (8-14.3 min);it was 22.2 minutes (17.1-29.5 min) for the 20 extremities of 14 patients in the classical group. While no additional cutting tool was used during cast removal in the modified group, additional cutting tools were used during removal of cast in 75% (15/20) of the patients in the classical group and statistically significant difference was found between two groups in terms of the use of cutting tools (p<0.001).
Conclusion: We found that the cast ends’ being marked by folding during plastering in idiopathic clubfoot patients treated with Ponseti technique is costless, easy to apply, significantly shortens cast removal time, does not require the use of cutting tools, and thus is a notably safe method for these patients.