bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variations in clinical presentation and biomarkers among biopsy‐proven lupus nephritis patients: a Top End retrospective cohort study
Authors: Xu Chi , Goh Kim Ling , Abeyaratne Asanga , Mogulla Manohar , Majoni William , Priyadarshana Kelum 
Published: October 2021

AbstractBackgroundLupus nephritis (LN) is a common feature of systemic lupus erythematosus (SLE) and affects 50% of patients with SLE. Racial differences in incidence and prevalence have been well documented worldwide. In Australia, higher incidence and prevalence of SLE had been previously reported in Aboriginal and Torres Strait Australians compared with non‐Indigenous Australians.AimTo describe the differences in clinical features and lupus biomarkers between Aboriginal and Torres Strait Islander Australian and non‐Indigenous Australian patients with LN.MethodsWe retrospectively identified all consecutive biopsy‐proven LN patients in our institution and compared the clinical features and lupus biomarkers between Aboriginal and Torres Strait Islander Australians and non‐Indigenous Australians.ResultsOf the 33 consecutive biopsy‐proven LN patients, 26 self‐identified as of Aboriginal and Torres Strait Islander descent. The estimated incidence of LN in Aboriginal and Torres Strait Islander Australian and non‐Indigenous Australians were 5.08 and 0.47 per 100 000 patient‐years respectively. Neurological manifestations (23.08% vs 0%), haematological manifestations (46.50% vs 16.67) and right‐heart catheter proven pulmonary arterial hypertension (23.08% vs 0%) were more frequently observed among Indigenous Australian patients compared with non‐Indigenous Australian patients. The incidence of positive extractable nuclear antigen was also higher among Indigenous Australian patients (84.62% vs 57.14%).ConclusionThe present study further supports the observation that lupus in Aboriginal and Torres Strait Islander Australians were of a ‘distinct phenotype’ compared with non‐Indigenous Australians. Future research should be aimed at delineating the reason for this observed difference.
HIF‐1α promotes the proliferation and migration of pulmonary arterial smooth muscle cells via activation of Cx43
Authors: Han Xiao‐Jian , Zhang Wei‐Fang , Wang Qin , Li Min , Zhang Chun‐Bo , Yang Zhang‐Jian , Tan Ren‐Jie , Gan Li‐Jun , Zhang Le‐Ling , Lan Xue‐Mei , Zhang Fang‐Lin , Hong Tao , Jiang Li‐Ping 
Published: October 2021

AbstractThe proliferation of pulmonary artery smooth muscle cells (PASMCs) is an important cause of pulmonary vascular remodelling in hypoxia‐induced pulmonary hypertension (HPH). However, its underlying mechanism has not been well elucidated. Connexin 43 (Cx43) plays crucial roles in vascular smooth muscle cell proliferation in various cardiovascular diseases. Here, the male Sprague‐Dawley (SD) rats were exposed to hypoxia (10% O2) for 21 days to induce rat HPH model. PASMCs were treated with CoCl2 (200 µM) for 24 h to establish the HPH cell model. It was found that hypoxia up‐regulated the expression of Cx43 and phosphorylation of Cx43 at Ser 368 in rat pulmonary arteries and PASMCs, and stimulated the proliferation and migration of PASMCs. HIF‐1α inhibitor echinomycin attenuated the CoCl2‐induced Cx43 expression and phosphorylation of Cx43 at Ser 368 in PASMCs. The interaction between HIF‐1α and Cx43 promotor was also identified using chromatin immunoprecipitation assay. Moreover, Cx43 specific blocker (37,43Gap27) or knockdown of Cx43 efficiently alleviated the proliferation and migration of PASMCs under chemically induced hypoxia. Therefore, the results above suggest that HIF‐1α, as an upstream regulator, promotes the expression of Cx43, and the HIF‐1α/Cx43 axis regulates the proliferation and migration of PASMCs in HPH.
Assessment of sleep disturbance in oral lichen planus and validation of PSQI: A case‐control multicenter study from the SIPMO (Italian Society of Oral Pathology and Medicine)
Authors: Adamo Daniela , Calabria Elena , Coppola Noemi , Lo Muzio Lorenzo , Giuliani Michele , Azzi Lorenzo , Maurino Vittorio , Colella Giuseppe , Rauso Raffaele , Montebugnoli Lucio , Gissi Davide Bartolomeo , Gabriele Mario , Nisi Marco , Sardella Andrea , Lodi Giovanni , Varoni Elena Maria , Giudice Amerigo , Antonelli Alessandro , Cabras Marco , Gambino Alessio , Vescovi Paolo , Majorana Alessandra , Bardellini Elena , Campisi Giuseppina , Panzarella Vera , Spadari Francesco , Marino Sonia , Pentenero Monica , Sutera Samuele , Biasotto Matteo , Gobbo Margherita , Guarda Nardini Luca , Romeo Umberto , Tenore Gianluca , Serpico Rosario , Lucchese Alberta , Lajolo Carlo , Rupe Cosimo , Aria Massimo , Gnasso Agostino , Mignogna Michele Davide ,   SIPMO (Italian Society of Oral Pathology, Medicine)
Published: October 2021

AbstractBackgroundThe wellbeing of oral lichen planus patients (OLPs) may be strongly influenced by a poor quality of sleep (QoS) and psychological impairment. The aims were to analyze the prevalence of sleep disturbance, anxiety, and depression in OLPs and to validate the Pittsburgh Sleep Quality Index (PSQI) in OLPs.MethodsThree hundred keratotic OLPs (K‐OLPs), 300 with predominant non‐keratotic OLP (nK‐OLPs), and 300 controls were recruited in 15 Italian universities. The PSQI, Epworth Sleepiness Scale (ESS), Hamilton Rating Scales for Depression and Anxiety (HAM‐D and HAM‐A), Numeric Rating Scale (NRS), and Total Pain Rating Index (T‐PRI) were administered.ResultsOral lichen planus patients had statistically higher scores than the controls in the majority of the PSQI sub‐items (p‐values < 0.001**). Moreover, OLPs had higher scores in the HAM‐D, HAM‐A, NRS, and T‐PRI (p‐values < 0.001**). No differences in the PSQI sub‐items’ scores were found between the K‐OLPs and nK‐OLPs, although nK‐OLPs suffered from higher levels of anxiety, depression, and pain (p‐values: HAM‐A, 0.007**, HAM‐D, 0.009**, NRS, <0.001**, T‐PRI, <0.001**). The female gender, anxiety, depression (p‐value: 0.007**, 0.001**, 0.020*) and the intensity of pain, anxiety, and depression (p‐value: 0.006**, <0.001**, 0.014*) were independent predictors of poor sleep (PSQI > 5) in K‐OLPs and nK‐OLPs, respectively. The PSQI’s validation demonstrated good internal consistency and reliability of both the total and subscale of the PSQI.ConclusionsThe OLPs reported an overall impaired QoS, which seemed to be an independent parameter according to the regression analysis. Hence, clinicians should assess QoS in OLPs and treat sleep disturbances in order to improve OLPs management.
First detection and molecular characterization of grapevine phytoplasmas in Kosovo
Authors: Bunjaku Agron , Alsaheli Zeinab , Mehle Nataša , Xhemali Bekri , Gjinovci Gazmend , Mehmeti Arben , Elbeaino Toufic 
Published: October 2021

AbstractA search for phytoplasma‐associated diseases was conducted for the first time in the main grapevine‐growing localities of the Dukagjini plain in Kosovo. A total of 144 samples were collected from grapevine cultivars displaying leaf yellowing, reddening, discolouration and irregular wood ripening, and analysed using nested and quantitative PCR assays. These assays showed that 35.4% of samples belonging to eight cultivars were positive to the presence of phytoplasmas in the 16SrXII group. The 16S rDNA phytoplasma sequences obtained from 15 samples shared identity greater than 99.5% with ‘Candidatus Phytoplasma solani’. Sequence analysis of the tuf gene showed that the strains found in Kosovar grapevines are in the tuf‐type b1 group, sharing 99.6% to 99.8% identity with ‘Ca. P. solani'‐related strains associated with the “bois noir” grapevine disease in many European countries; the secY gene sequences, on the other hand, shared 100% identity with ‘Ca. P. solani' strains from Bosnia and Herzegovina, Serbia, Croatia and Turkey. This study constitutes the first report on the presence and molecular characterization of phytoplasmas in Kosovar vineyards. Based on these results, it is recommended that testing for phytoplasma be included in the certification program for grapevine in Kosovo.
Relationships Between Phonological Awareness and Reading in Spanish: A Meta‐Analysis
Authors: Míguez‐Álvarez Carla , Cuevas‐Alonso Miguel , Saavedra Ángeles 
Published: October 2021

AbstractPrevious meta‐analyses of the relationship between phonological awareness (PA) and reading have been conducted mostly in children who speak English, a language with an opaque writing system. In this study, we present a meta‐analysis that examined mean correlations between three PA tasks testing phonemic, syllabic, and intrasyllabic awareness and three reading tasks testing word reading, nonword reading, and reading comprehension in Spanish, a language with a near‐transparent writing system. A random‐effects model of 47 articles (N = 7,956) was used for a multiple correlation study that showed a significantly moderate correlation between some of the PA subcategories and the reading tasks in Spanish‐speaking children. The largest correlation values were found between syllabic awareness and reading, which highlights the importance of syllable recognition during reading acquisition. In addition, we found that intrasyllabic awareness also plays an important role in reading in Spanish. The findings are discussed from a cross‐linguistic perspective.
Brain abscesses due to odontogenic infection: Case series
Authors: Da Silva Ana Cristina Corrêa , Viera Patrícia Verónica Aulestia , Bittencourt Augusto Arcemiro , Cavalcante Juliana Vieira , Blanco Tathiana Marinho , Matias Diogo Toledo , Rocha André Caroli , De Melo Peres Maria Paula Siqueira , Franco Juliana Bertoldi 
Published: October 2021

AbstractBrain abscesses due to odontogenic infection are infrequent, but they deserve attention due to the high incidence of serious complications and the high mortality rate. This article aimed to report five cases of cerebral abscess due to odontogenic infection, of patients attended in the Clinical Hospital of Medical School of the University of São Paulo (HCFMUSP). In all cases, treatment consisted of draining the brain abscess, antibiotic therapy and extraction of all teeth responsible for the infection. Streptococcus spp. was the causative agent of all the cases reported in this article. The purpose of the study was to highlight the importance of the dental approach for the resolution of cases.
Choosing a CRRT machine and modality
Authors: Macedo Etienne , Cerdá Jorge 
Published: October 2021

AbstractExpanded use and steady improvements in continuous renal replacement techniques (CRRT) have enhanced the safety of the application of kidney replacement therapy (KRT) to hemodynamically unstable intensive care unit (ICU) patients. The longer duration of therapy and the personalized prescription provided by continuous therapies are associated with greater hemodynamic stability and a modestly higher likelihood of kidney recovery than standard intermittent hemodialysis (IHD). Studies designed to evaluate the effect on mortality over intermittent therapies lack evidence of benefit. A lack of standardization and considerable variation in how CRRT is performed leads to wide variation in how the technique is prescribed, delivered, and optimized. Technology has progressed in critical care nephrology, and more progress is coming. New CRRT machines are equipped with a friendly user interface that allows easy performance and monitoring, permitting outcome measurements and improved patient quality control. This review discusses the key concepts necessary to guide nephrologists to prescribe and deliver KRT to critically ill ICU patients.
Performance‐determining factors in biathlon prone shooting without physical stress
Authors: Köykkä Miika , Laaksonen Marko S. , Ihalainen Simo , Ruotsalainen Keijo , Linnamo Vesa 
Published: October 2021

This study investigated the most important factors determining biathlon prone shooting performance. Ten female and 16 male biathletes (age 19.9 ± 2.9 years) from the national teams of Finland and Vuokatti‐Ruka Sports Academy performed 6 × 5 biathlon prone shooting shots without physical stress under laboratory conditions. Shooting performance and multiple aiming point trajectory variables were measured together with an analysis of triggering force. Based on the aiming point trajectory data principal component analysis, we identified four technical components in biathlon prone shooting: stability of hold, aiming accuracy, cleanness of triggering, and timing of triggering. Multiple regression analysis (MRA) further determined that cleanness of triggering, aiming accuracy, and timing of triggering accounted for 80% of mean shooting performance (p < 0.001). Better stability of hold, aiming accuracy and cleanness of triggering were directly associated with better shooting performance (0.62 ≤ |r| ≥0.79, all p < 0.001). Better stability of hold measures were also associated with better cleanness of triggering, and higher pre‐shot trigger force levels were associated with better stability of hold and cleanness of triggering. These results indicate that with both direct and indirect effects on performance, stability of hold seems to be a general prerequisite for successful biathlon shooting. The results also highlight the importance of aiming accuracy, cleanness and timing of triggering, along with a high pre‐shot trigger force level. The variables identified in this study could be used to assess biathletes’ performance in the most relevant shooting technical aspects to guide the emphasis of their shooting training.
Evaluation of urine electrolytes for the diagnosis of hypoadrenocorticism in dogs
Authors: Dropkin Casey A. , Kruger John M. , Langlois Daniel K. 
Published: October 2021

AbstractBackgroundMost dogs with primary hypoadrenocorticism (HA) have a mineralocorticoid deficiency, which decreases renal tubular sodium reabsorption and potassium excretion. Limited information is available concerning the clinical value of measuring urine electrolytes to aid in an HA diagnosis.ObjectivesWe aimed to evaluate the diagnostic utility of urine electrolyte measurements in dogs with HA.MethodsUrine sodium and potassium concentrations were measured in 89 dogs, including 39 dogs with HA and 50 controls with nonadrenal illness. Fractional excretions of sodium (FENa) and potassium (FEK) were also calculated. Urine electrolytes and fractional excretion values were compared between the groups. Sensitivities and specificities were determined for various cut‐points.ResultsThe median urine sodium to potassium (Na:K) ratio was twofold greater (P < .001), and median FENawas fourfold greater (P < .001) in HA dogs as compared with controls. However, no cut‐point for any variable with >90% sensitivity or specificity provided a corresponding specificity or sensitivity of >50%. When only dogs with abnormal serum or plasma electrolytes were included in the analyses, absolute urine electrolyte concentrations and FENawere not different between study populations (P > .05 for all comparisons), but the FEKwas increased (P = .005) and the urine potassium:creatinine ratio was decreased (P < .001) in the control dogs compared with the dogs with HA.ConclusionsUrine electrolyte concentrations and fractional excretions are altered in dogs with HA. However, substantial overlap exists with control dogs with nonadrenal illness. Therefore, these values are unlikely to have diagnostic utility for dogs with HA.
Effectiveness of interventions that support penicillin allergy assessment and de-labeling of patients by non-allergy specialists: a systematic review protocol
Authors: Powell Neil , Kohl Declan , Ahmed Shadia , Kent Bridie , Sandoe Jonathan , Tonkin-Crine Sarah , Owens Rhys , Stephens Jennie , Upton Mathew 
Published: October 2021

ABSTRACT

Objective:
This review will systematically examine and synthesize the evidence evaluating the effectiveness and safety of interventions that enable non-allergy specialist health care workers to assess allergy risk in patients with reported penicillin allergies and subsequently remove erroneous allergy records.

Introduction:
The potential benefits of removing erroneous penicillin allergy labels (de-labeling) are wide-ranging. Penicillin allergy assessment and de-labeling is an antibiotic stewardship priority. Delivery of such assessment and de-labeling by non-allergy specialists has been reported in several studies, but the effectiveness and safety have not been formally synthesized. This is a necessary step in the upscaling of penicillin allergy assessment services.

Inclusion criteria:
This review will consider quantitative studies using appropriate designs. The studies will include adults and pediatric patients who have undergone penicillin allergy assessment and de-labeling by non-allergy specialists in any health care setting.

Methods:
A range of databases will be searched to identify studies published in English, with no date limit applied. Unpublished studies and gray literature will also be searched. Title and abstract screening, and assessment of selected full texts against the inclusion criteria will be conducted by at least two independent reviewers. Identified studies will be assessed for methodological quality using standardized critical appraisal instruments. Data will be extracted and categorized using the EPOC taxonomy, and the effectiveness and safety of the intervention will be determined. Where possible, data will be pooled to facilitate meta-analysis. Data from heterogeneous studies will be reported narratively. The GRADE approach for grading the certainty of evidence will be followed.

Systematic review registration number:
PROSPERO CRD42020219044
Associations Among Home Indoor Environmental Quality Factors and Worker Health While Working From Home During COVID-19 Pandemic
Authors: Awada Mohamad , Becerik-Gerber Burcin , Lucas Gale , Roll Shawn C. 
Published: October 2021

Abstract
The outbreak of SARS-CoV-2 virus forced office workers to conduct their daily work activities from home over an extended period. Given this unique situation, an opportunity emerged to study the satisfaction of office workers with indoor environmental quality (IEQ) factors of their houses where work activities took place and associate these factors with mental and physical health. We designed and administered a questionnaire that was open for 45 days during the COVID-19 pandemic and received valid data from 988 respondents. The results show that low satisfaction with natural lighting, glare, and humidity predicted eye-related symptoms, while low satisfaction with noise was a strong predictor of fatigue or tiredness, headaches or migraines, anxiety, and depression or sadness. Nose- and throat-related symptoms and skin-related symptoms were only uniquely predicted by low satisfaction with humidity. Low satisfaction with glare uniquely predicted an increase in musculoskeletal discomfort. Symptoms related to mental stress, rumination, or worry were predicted by low satisfaction with air quality and noise. Finally, low satisfaction with noise and indoor temperature predicted the prevalence of symptoms related to trouble concentrating, maintaining attention, or focus. Workers with higher income were more satisfied with humidity, air quality, and indoor temperature and had better overall mental health. Older individuals had increased satisfaction with natural lighting, humidity, air quality, noise, and indoor temperature. Findings from this study can inform future design practices that focus on hybrid home-work environments by highlighting the impact of IEQ factors on occupant well-being.
Fear, Anger, and Loneliness: Emotional Pain and Referee Attrition in English Grassroots Football
Authors: Potrac Paul A. , Hall Edward T. , Nichol Adam J. 
Published: October 2021

This interpretive study provides original insights into the socioemotional experiences that contributed to referee attrition in English grassroots football. Data were generated using an online survey (n = 251) and in-depth interviews (n = 20) with former referees. Using complementary symbolic interactionist and relational conceptualizations of identity, social interaction, and emotional pain, the analysis addressed the participants’ interpretations of their problematic encounters with the various significant others (e.g., coaches, managers, players, spectators, and administrators) that comprised their respective social networks in grassroots football. Importantly, the participants described several emotionally painful issues related to match day environments, disciplinary proceedings, and deployment and development processes that simultaneously coexisted alongside and exacerbated one another. The findings present important implications for those individuals and governing bodies who are responsible for referee retention.
Improving early diagnosis of cardiovascular disease in patients with type 2 diabetes and COPD: protocol of the RED-CVD cluster randomised diagnostic trial
Authors: Groenewegen Amy , Zwartkruis Victor W , Rienstra Michiel , Hollander Monika , Koffijberg Hendrik , Cramer Maarten Jan Maria , van der Schouw Yvonne T , Hoes Arno W , de Boer Rudolf A , Rutten Frans H 
Published: October 2021

IntroductionThe early stages of chronic progressive cardiovascular disease (CVD) generally cause non-specific symptoms that patients often do not spontaneously mention to their general practitioner, and are therefore easily missed. A proactive diagnostic strategy has the potential to uncover these frequently missed early stages, creating an opportunity for earlier intervention. This is of particular importance for chronic progressive CVDs with evidence-based therapies known to improve prognosis, such as ischaemic heart disease, atrial fibrillation and heart failure.Patients with type 2 diabetes or chronic obstructive pulmonary disease (COPD) are at particularly high risk of developing CVD. In the current study, we will demonstrate the feasibility and effectiveness of screening these high-risk patients with our early diagnosis strategy, using tools that are readily available in primary care, such as symptom questionnaires (to be filled out by the patients themselves), natriuretic peptide measurement and electrocardiography.Methods and analysisThe Reviving the Early Diagnosis-CVD trial is a multicentre, cluster randomised diagnostic trial performed in primary care practices across the Netherlands. We aim to include 1300 (2×650) patients who participate in a primary care disease management programme for COPD or type 2 diabetes. Practices will be randomised to the intervention arm (performing the early diagnosis strategy during the routine visits that are part of the disease management programmes) or the control arm (care as usual). The main outcome is the number of newly detected cases with CVDs in both arms, and the subsequent therapies they received. Secondary endpoints include quality of life, cost-effectiveness and the added diagnostic value of family and reproductive history questionnaires and three (novel) biomarkers (high-sensitive troponin-I, growth differentiation factor-15 and suppressor of tumourigenicity 2). Finally newly initiated treatments will be compared in both groups.Ethics and disseminationThe protocol was approved by the Medical Ethical Committee of the University Medical Center Utrecht, the Netherlands. Results are expected in 2022 and will be disseminated through international peer-reviewed publications.Trial registration numberNTR7360.