bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID-19-like symptoms on occurrence of anxiety/depression during lockdown among the French general population
Authors: Mary-Krause Murielle , Herranz Bustamante Joel José , Héron Mégane , Andersen Astrid Juhl , El Aarbaoui Tarik , Melchior Maria 
Published: July 2021

BackgroundThe outbreak of the COVID-19 epidemic lead to high levels of morbidity and mortality around the globe. Consequences of this outbreak and possible associated infection are an increase in mental health disorders and an increased likelihood of internalizing problems, particularly depression. However, to date few studies have tested this hypothesis while taking into account individuals’ preexisting mental health difficulties.MethodsWe used longitudinal data collected among 729 persons in the context of the French TEMPO cohort between March and June 2020 (7 waves of data collection). COVID-19-like symptoms as well as anxiety/depression (assessed by the Adult Self Report), were reported at each wave of data collection. To study the relationship between COVID-19-like symptoms and anxiety/depression, we used generalized estimation equation (GEE) models controlled for socio-demographic and health-related characteristics, including anxiety/depression prior to 2020.ResultsOverall, 27.2% of study participants reported anxiety/depression during lockdown. 17.1% of participants reported COVID-19-like symptoms during the course of follow-up, 7.3% after the beginning of lockdown, with an average number of 2.7 symptoms, and 3.6% reported respiratory distress. In multivariate analyses, nearly all the considered indicators of COVID-19-like symptoms were associated with higher odds of symptoms of anxiety/depression (symptoms Yes/No: OR = 1.66, 95% CI = 1.08–2.55; symptoms after the beginning of lockdown: OR = 1.91, 95% CI = 1.03–3.52; number of symptoms: OR for each additional symptom = 1.19, 95% CI = 1.02–1.39. This relationship exists after taking into account prior symptoms of anxiety/depression, which are associated with a 5-fold increased likelihood of psychological distress. And this impact is stronger among men than women.ConclusionsOur study shows higher risk of anxiety/depression among persons who experienced COVID-19-like symptoms, even after accounting for prior mental health difficulties. COVID-19 infection could have both a direct and indirect impact on the occurrence of psychological difficulties, and this association should be studied in greater detail.
A human ex vivo coculture model to investigate peritoneal metastasis and innovative treatment options
Authors: Mönch Dina , Koch Jana , Maaß Annika , Janssen Nicole , Mürdter Thomas , Renner Philipp , Fallier-Becker Petra , Solaß Wiebke , Schwab Matthias , Dahlke Marc-H. , Schlitt Hans J. , Leibold Tobias 
Published: July 2021

Abstract

Objectives
Peritoneal metastasis (PM) is commonly observed in patients with colorectal cancer (CRC). The outcome of these patients is poor, with an average survival of only six months without therapy, which requires a better understanding of PM biology and new treatment strategies.

Methods
We established and characterized a human ex vivo peritoneal model to investigate the mechanisms of peritoneal seeding and possible treatment options. For this, CRC cell lines and patient-derived tumor organoids were cultured together with human peritoneum to investigate the invasion of malignant cells and the effects of local chemotherapy.

Results
Fresh human peritoneum was cultured for up to three weeks in a stainless steel ring system, allowing for survival of all peritoneal structures. Peritoneal cell survival was documented by light microscopy and immunohistochemical staining. Further, immunohistological characterization of the tissue revealed CD3-positive T-lymphocytes and vimentin-positive fibroblasts within the peritoneum. In addition, extracellular matrix components (collagens, matrix metalloproteinases) were localized within the tissue. Coculture with CRC cell lines and patient-derived CRC organoids revealed that cancer cells grew on the peritoneum and migrated into the tissue. Coculture with CRC cells confirmed that hyperthermal treatment at 41 °C for 90 min significantly enhanced the intracellular entry of doxorubicin. Moreover, treatment with mitomycin C under hyperthermic conditions significantly reduced the amount of cancer cells within the peritoneum.

Conclusions
This human ex vivo peritoneal model provides a stringent and clinically relevant platform for the investigation of PM and for further elucidation of possible treatment options.
Radioiodinated esomeprazole as a model for peptic ulcer localization
Authors: Sanad M. H. , Eyssa H. M. , Gomaa N. M. , Marzook F. A. , Bassem S. A. 
Published: July 2021

Abstract
This work focuses on tracking stomach ulcer localized in mice. High labeling yield and radiochemical purity were achieved for the formation of a [125I]esomeprazole radiotracer at optimum conditions of oxidizing agent content (chloramines-T (Ch-T), 100 μg), substrate amount (Esom, 100 μg), pH of reaction mixture (6), reaction time (30 min) and temperature (37 °C), using radioactive iodine-125 (200–450 MBq). The radiolabeled compound, [125I]esom, was stable in serum and saline solution during 24 h. Esom is acting as a histamine-2-receptor antagonist (H2RA). Biodistribution studies were carried in normal and ulcerated mice. High uptake of 78.12 ± 0.80% injected dose/g organ (ID/g) observed in ulcerated mice confirmed the suitability of [125I]esomeprazole as a novel radiotracer for stomach imaging.
The role of A268V exon-7 polymorphism of PPARA in development of axial spondyloarthritis
Authors: Akbulut Ekrem , Yolbas Servet , Ozgen Metin 
Published: July 2021

Abstract

Objectives
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that mainly affects the axial skeleton. Peroxisome proliferator activated receptor alpha (PPARA) is an intracellular transcription factor, which play a role in inflammation and osteoblasting activity. This study is designed to investigate the relationship of NG_012204.2:p.Ala268Val polymorphism of PPARA with axSpA risk and its role in disease development.

Methods
This study was conducted with 168 patients and 181 controls. Genotyping was done with MALDITOF. Gene expression level was analyzed by quantitative real time PCR (RT-qPCR). The protein homology models of PPARA were created with ProMod3. Ligand binding dynamics were tested using the AutoDock4 docking program. Statistical evaluations were made with SPSS (ver24) and GeneGlobe.

Results
Our results showed that C>T polymorphism causing NG_012204.2:p.Ala268Val change was associated with disease risk (p=0.024) and T allele increased disease risk 1.7 times (95% CI=1.070–2.594). PPARA expression decreased (p<0.05) in individuals carrying the T allele. We determined that the ligand entry pocket was opened 1.1 Å in the polymorphic PPARA. Polymorphic change caused a decrease in the ligand binding affinity.

Conclusions
Our results provide an important contribution to elucidating the development of axSpA and demonstrate the potential of PPARA as a marker for the diagnosis of axSpA.
Intelligence in Strategic Games
Authors: Naumov Pavel , Yuan Yuan 
Published: July 2021

If an agent, or a coalition of agents, has a strategy, knows that she has a strategy, and knows what the strategy is, then she has a know-how strategy. Several modal logics of coalition power for know-how strategies have been studied before.
The contribution of the article is three-fold. First, it proposes a new class of know-how strategies that depend on the intelligence information about the opponents’ actions. Second, it shows that the coalition power modality for the proposed new class of strategies cannot be expressed through the standard know-how modality. Third, it gives a sound and complete logical system that describes the interplay between the coalition power modality with intelligence and the distributed knowledge modality in games with imperfect information.
Rancang bangun turbin uap pada Pembangkit Listrik Tenaga Sampah (PLTSa) Kapasitas 1,45 KW di Lingkungan Kampus Unsika
Authors: Darmawan Rais 
Published: July 2021

Abstrak: Sampah merupakan salah satu permasalahan perkotaan terutama untuk di kota – kota besar di Indonesia tak terkecuali di Karawang, dan ini merupakan tantangan bagi setiap kota untuk mengelolah sampah ini. Dinas Lingkungan Hidup dan Kebersihan (DLHK) Karawang mencatat populasi sampah mencapai 900 ton per harinya. Untuk itu pada penelitian ini akan dilakukan perancangan PLTSa. Sebagai salah satu solusi pemanfaatan sampah. pada penelitian ini akan merancang turbin uap jenis impuls sebagai salah satu komponen PLTSa dengan diameter turbin 40 cm. Dari hasil pengujian alat PLTSa putaran operasional turbin uap yang digunakan 1500 Rpm dengan tekanan 5 Bar, yang menghasilkan daya output 1,45 KW dan daya internalnya 1,337 KW yang tersambung pada alternator dan menghasilkan listrik 26 volt tanpa beban, serta 12,6 volt ketika dihubungkan ke accu. Efisiensi yang terdapat pada turbin uap 49,6 % dan efisiensi internal relatif turbin uap sebesar 70 %. Kata kunci: Sampah, Turbin Uap, Kecepatan, Tegangan, dan Efisiensi.
Pengembangan Buku Panduan Pelatihan Kesadaran Belajar dengan Menggunakan Teknik Self-Talk dalam Bimbingan Kelompok Siswa SMP
Authors: Aslami Dini Indah , Simon Irene , Triyono Triyono 
Published: July 2021

Abstract: Learning awareness is best for each student. Learning awareness makes learners have a distinct willingness to learn so that learning is no longer necessary. The purpose of the research and development is to produce a guidebook for learning awareness training by using self-talk technique in group guidance. This research is a type of research and development that adapts the development model from Borg and Gall. The steps taken in this research and development do not follow the overall development steps by Borg and Gall. This research and development is only up to the fifth step, namely product revision. The guidebook developed have been validated by two instrument experts, two guidance and counseling material experts and two media experts and have been tested on two prospective product users (school counselors). Based on the results of expert trials and user trials of manual products, they get an assessment that is very feasible to use.
Abstrak: Kesadaran diri dalam belajar sebaiknya dimiliki setiap pelajar. Kesadaran dalam belajar membuat peserta didik memiliki kemauan sendiri dalam belajar sehingga anak tersebut tidak perlu lagi untuk dipaksa untuk belajar.Tujuan dari penelitian dan pengembangan untuk menghasilkan panduan pelatihan kesadaran belajar siswa SMP dengan penggunaan teknik self-talk dalam bimbingan kelompok. Penelitian ini adalah jenis penelitian dan pengembangan yang mengadaptasi model pengembangan dari Borg dan Gall. Langkah-langkah yang dilakukan dalam penelitian dan pengembangan ini tidak mengikuti keseluruhan langkah pengembangan oleh Borg dan Gall. Penelitian dan pengembangan ini hanya hingga langkah kelima yaitu revisi produk. Panduan yang dikembangkan sudah divalidasi oleh dua orang ahli instrumen, dua orang ahli materi bimbingan dan konseling dan dua orang ahli media serta sudah diuji cobakan kepada calon pengguna produk yaitu dua orang konselor sekolah. Berdasarkan hasil uji coba ahli dan uji coba pengguna produk panduan mendapatkan penilaian sangat layak digunakan.
Pengembangan Panduan Konseling Kelompok Teknik Psikodrama untuk Mengatasi Masalah Psychological Well-Being Siswa SMP
Authors: Kaedati Sityalawia H. , Zen Ella Faridati , Fauzan Lutfi 
Published: July 2021

Abstract: This research goal is to develop a group counseling guide for psychodrama techniques to overcome problems psychological well-being in junior high school students. Guidelines are used by counselors in providing guidance and counseling services that have accuracy, usefulness, convenience, and attractiveness, and can be both beneficial and acceptable. theory and practicality. The research method used is the Borg and Gall research model in 7 stages, namely (1) data collection, (2) planning, (3) designing the initial media format, (4) validation testing, (5) product revision, 6) product user testing. , 7) final revision. The results of the validation test from material experts showed a validity index of 0.73 and was included in the high category, media experts showed a percentage of 3.89 which was included in the very high category and potential product users with a percentage of 3.77 were still in the very high category. These results indicate that the guide developed by the researcher has met the acceptance criteria and is suitable for use by counselors as a guide in providing guidance and counseling services in schools.
Abstrak: Penelitian ini bertujuan mengembangkan panduan konseling kelompok teknik psikodrama untuk mengatasi masalah psychological well-being pada siswa SMP. Panduan digunakan oleh konselor dalam memberikan layanan bimbingan dan konseling yang memiliki ketepatan, kegunaan, kemudahan, dan kemenarikan, serta dapat bermanfaat sekaligus diterima secara teori maupun kepraktisannya. Metode penelitian yang digunakan adalah model penelitian Borg and Gall dalam 7 tahap yaitu (1) pengumpulan data, (2) perencanaan, (3) merancang format awal media, (4) uji validasi, (5) revisi produk, 6) uji pengguna produk, 7) revisi akhir. Hasil uji validasi dari ahli materi menunjukan indeks validitas sebesar 0,73 dan masuk dalam kategori tinggi, ahli media menunjukan persentase sebesar 3,89 masuk dalam kategori sangat tinggi dan calon pengguna produk dengan persentase 3,77 masih dalam kategori sangat tinggi. Hasil tersebut menunjukan bahwa panduan yang dikembangkan oleh peneliti telah memenuhi kriteria keberterimaan dan layak digunakan oleh konselor sebagai panduan dalam memberikan layanan bimbingan dan konseling di sekolah.
Role of gender & age in chronic periodontal disease
Authors: Jain Ashish , Bhavsar Neeta V 
Published: July 2021

There is lot of literature suggesting a gender based heterogeneity in many human chronic diseases including periodontal disease. To analyze and compare the clinical periodontal disease parameters & serum biochemical markers of periodontal inflammation in systemically healthy age stratified adult male and female patients suffering from chronic destructive periodontal disease. Cross sectional observational study in a hospital setting A total of 300 subjects, both genders were enrolled based on predefined criteria and were categorized in 6 groups of 50 subjects each. Complete medical and dental history was taken to screen before enrollment. All subjects underwent complete periodontal examination, including evaluation of Plaque index (PI), Probing pocket depth (PPD) and Clinical attachment level (CAL), Bleeding on Probing (BOP). Blood samples were taken for analysis of inflammatory biomarkers viz interleukin (IL)-1β, osteoprotegrin (OPG), matrix metalloproteinase (MMP)- 8 & interleukin (IL)- 6. IBM SPSS STATISTICS (version 22.0) Clinical parameters of periodontal status were higher in females as compared to males except BOP. However, only PPD and CAL showed significant difference. Higher serum levels of IL-1β, OPG and Il-6 were observed in females (2.10 + 26.82, 168.18 + 49.84 , 29.17 + 99.20 pg/ml) than males (1.90 + 7.27 , 145.00 + 39.60 , (25.83 + 189.09pg/ml) respectively, but significant difference was observed only for OPG. A statistically significant higher level of MMP-8 was observed in males (3003.33 + 772.33 pg/ml) as compared to females (1398.33 + 1218.10 pg/ml). The findings of current investigation has identified significant differences in the clinical and specific biochemical mediators(IL-1β, IL-6, OPG, MMP-8) across groups and subgroups of the population To ascertain the impact of gender and age in the causation and pathogenesis of inflammatory periodontal disease, further well designed prospective investigations are needed . The study findings point towards the identification of specific biomarkers in individual subgroup/group based on age and gender. These shall pave path to develop predictive models, screening tools and early diagnostic strategies for chronic periodontal disease for Indian population.
THE EXTENT OF PREVAILING STIGMA AMONG HEPATITIS C PATIENTS IN PESHAWAR KHYBER PUKHTUNKHWA PAKISTAN
Authors: Ullah Qudrat , Ullah Asad , Khan Younas , Khan Farooq Ahmad , Ali Sajid 
Published: July 2021

Purpose of the study: This study was conducted with the sole aim to assess the prevalence of stigma in patients with Hepatitis C and to assess the association between them through the quantitative measure, i.e. chi-square test.
Methodology: A cross-sectional-based study was designed from 361 sampled respondents (Hepatitis C patients) in 3 teaching hospitals in Peshawar-Pakistan. Data was collected on a three-level Likert Scale interview schedule covering both the study variables. A conceptual framework comprised of the dependent variable health-related quality of life among HCV patients was cross-tabulated and indexed with the independent variable social stigma disease carry through the application of chi-square test statistics.
Principal Findings: The association of Health-Related Quality of Life was found significant with perceiving shaking hands with HCV patients as a cause of the disease (P=0.018), people hesitate in embracing HCV patients (P=0.000), people were uncomfortable while sitting beside HCV patients (P=0.001), family members are reluctant in carrying out HCV test for other family members (P=0.028), patients were given due attention at family (0.007), patients shared their problem with others without any fear (P=0.014), patients telling people about their disease (P=0.000), patients blamed themselves for disease (p=0.009) and patients participated in social activities (P=0.000).
Applications of this study: Raising awareness, through reliable sources, among masses, especially with relation to symptoms and causes of HCV, to reduce the reluctance of people in contacting HCV patients and training families of HCV patients to adopt the allowable social interaction with HCV patients were some of the recommendations in light of the study.
Novelty/Originality of this study: This cross-sectional study is designed to assess the prevalence of stigma in patients with Hepatitis C and to assess the association between them through the quantitative measure, i.e. chi-square test. This research has come under the domain of medical sociology, social psychology, along with diagnosing the hidden dilemma, which exists since its existence.
Computing the temporal intervals by making a Throne-Morris wormhole from a Kerr black hole in the context of f(R,T) gravity
Authors: Harikant Aruna , Singha Roy Sanjeevan , Bhattacharjee Deep 
Published: July 2021

In the paper we will proceed towards taking the larger root of and make it equal to zero to remove the event horizon of a Kerr black hole (BH) in Boyer-Lindquist coordinates with a prevalent ring type singularity that can be smoothen by a tunneling approach of a spherinder thereby proceeding safely towards the Cauchy horizon with the deduced intervals computed in detail for the time travel in the Throne-Morris wormhole (WH) approach under gravity without the presence of any exotic matter at the WH mouth thereby preserving the asymptotically solutions of flaring out conditions and mouth opening during the course of the journey through the Einstein-Rosen bridge. An approach has been organized in the paper in which not only time travel is possible without exotic matter but also time travel is flexible to past and future in the Einstein’s universe by eliminating all sorts of paradoxes by spatial sheath through 2D approach of temporal dimensions.
MAKNA TRADISI NGOBENG PADA MASYARAKAT MELAYU PALEMBANG
Authors: Pratama Aldy Hidayat , Amilda Amilda , Fitriah Fitriah 
Published: July 2021

Palembang memiliki banyak kebudayaan, tradisi, serta adat istiadat yang masih banyak orang yang belum mengetahuinya terutama dari generasi muda pada saat ini. Budaya maupun tradisi dapat dipercaya secara turun-temurun dan merupakan suatu identitas bangsa harus harus dijaga dan dilestarikan oleh para penerus bangsa. Salah satunya adalah tradisi ngobeng yang ada di Palembang. Adapun masalah dalam penelitian ini yang dibahas yaitu bagaimana proses pelaksanaan dan makna yang terdapat dalam tradisi ngobeng pada masyarakat Melayu Palembang.
Penelitian ini menggunakan studi penelitian deskriptif dengan metode kualitatif dan dengan sumber data primer nya yaitu wawancara secara langsung dengan informannya yaitu ketua adat Palembang, Sejarahwan Palembang, Budayawan, serta masyarakat yang pernah terlibat langsung mengikuti atau menjalani tradisi ngobeng tersebut. Sumber data sekunder nya yaitu diperoleh dari hasil dokumentasi, buku-buku, jurnal, dan laporan lainnya dari hasil penelitian yang terkait. Teknik pengumpulan datanya dilakukan dengan cara observasi, wawancara, dan dokumentasi.
Hasil penelitian ini yang bisa di dapatkan oleh peneliti terkait apa itu tradisi ngobeng yaitu merupakan salah satu tradisi warisan budaya peninggalan leluhur dalam menghormati tamu dan memuliakan tamu dalam kegiatan seperti acara pernikahan, sedekahan, syukuran, dan kegiatan besar keagamaan lainnya. Budaya tradisi ngobeng Palembang ini merupakan hasil asimilasi dari tradisi Islam dengan kebudayaan lokal yaitu dengan makannya secara bersama-sama dengan makannya memakai tangan secara langsung dan sambal duduk bersila sesuai apa yang diajarkan atau disunnahkan oleh Nabi Muhammad SAW. Dalam tradisi ngobeng ini adanya makna yang terkandung dalam tradisi ngobeng tersebut serta bagaimana proses pelaksanaannya yang dijalankannya pada masyarakatnya dalam bekerjasama saling bergotong-royong.
Penguatan peran orang tua dalam mengatasi kejenuhan belajar anak selama pandemi Covid-19
Authors: Trisnani Novy , Astuti Anita Dewi 
Published: July 2021

[Bahasa]: Pembelajaran Jarak Jauh (PJJ) di masa pandemi Covid-19 menjadi salah satu penyebab munculnya kejenuhan belajar pada diri anak. Orang tua dengan tugas dan peran barunya dalam mendampingi anak selama belajar dari rumah diharapkan memiliki pengetahuan dan pemahaman bagaimana mengatasi kejenuhan belajar yang dialami oleh anak. Tujuan diselenggarakannya kegiatan pengabdian ini adalah memberikan pengetahuan dan pemahaman kepada orang tua tentang cara dan strategi dalam mengatasi kejenuhan belajar anak di masa pandemi Covid-19. Kegiatan pengabdian laksanakan dengan cara sosialisasi langsung kepada warga. Sasaran dari pengabdian ini adalah orang tua yang memiliki anak usia sekolah bertempat tinggal di Dusun Kembang Kapanewon Pengasih berjumlah 32 orang. Tahapan yang diterapkan dalam pelaksanaan kegiatan sosialisasi ini adalah persiapan, pelaksanaan, dan evaluasi kegiatan pengabdian. Berdasarkan hasil evaluasi kegiatan diperoleh disimpulkan bahwa orang tua merasakan manfaat dari kegiatan pengabdian ini dan mereka memiliki pengetahuan dan pemahaman tentang cara dan strategi dalam mengatasi kejenuhan belajar anak di masa pandemi Covid-19. Kegiatan pengabdian ini mampu membekali orang tua dalam mendampingi anak-anak mereka dalam belajar selama pendemi Covid-19.
Kata Kunci: penguatan peran orang tua, kejenuhan belajar, pandemi Covid-19
[English]: Long distance learning during Covid-19 pandemic became one of the causes of children’s boring in learning. Parents with their new duties and roles in accompanying their children during learning from home are expected to have knowledge to overcome the problem. The purpose of this community service program is to provide knowledge and understanding to parents about strategies for overcoming children's boring. The program was carried out by a direct socialization to 32 parentswho have school-age children in Dusun Kembang Kapanewon Pengasih. The program follows some stages; preparation, implementation, and evaluation. Based on the results of the evaluation, it was concluded that parents feel the benefits of this program; they have knowledge and understanding of strategies to overcome their children's problem. This community service is able to support the parents in accompanying their children during learning from home in this pandemic.
Keywords: the roles of parents, boring in learning, Covid-19 pandemic