bluuebunny/crossref_metadata_2025_split huggingface dataset:
Access to MRI for patients with cardiac pacemakers and implantable cardioverter defibrillators
Authors: Pieri Christopher , Bhuva Anish , Moralee Russell , Abiodun Aderonke , Gopalan Deepa , Roditi Giles H , Moon James C , Manisty Charlotte 
Published: May 2021

ObjectiveTo determine provision of MRI for patients with cardiac implantable electronic devices (CIEDs; pacemakers and defibrillators) in England, to understand regional variation and assess the impact of guideline changes.MethodsRetrospective data related to MRI scans performed in patients with CIED over the preceding 12 months was collected using a structured survey tool distributed to every National Health Service Trust MRI unit in England. Data were compared with similar data from 2014/2015 and with demand (estimated from local CIED implantation rates and regional population data by sustainability and transformation partnerships (STPs)).ResultsResponses were received from 212 of 223 (95%) hospitals in England. 112 (53%) MRI units’ scan patients with MR-conditional CIEDs (10% also scan non-MR conditional devices), compared with 46% of sites in 2014/2015. Total annual scan volume increased over fourfold between 2014 and 2019 (1090 to 4896 scans). There was widespread geographical variation, with five STPs (total population >3·5 million representing approximately 25 000 patients with CIED) with no local provision. There was no correlation between local demand (CIED implantation rates) and MRI provision (scan volume). Complication rates were extremely low with three events nationally in 12 months (0·06% CIED–MRI scans).ConclusionsProvision of MRI for patients with CIEDs in England increased over fourfold in 4 years, but an estimated 10-fold care gap remains. Almost half of hospitals and 1 in 10 STPs have no service, with no relationship between local supply and demand. Availability of MRI for patients with non-MR conditional devices, although demonstrably safe, remains limited.
Cardiovascular risk factors in gout, psoriatic arthritis, rheumatoid arthritis and ankylosing spondylitis: a cross-sectional survey of patients in Western Sweden
Authors: Landgren Anton Jonatan , Dehlin Mats , Jacobsson Lennart , Bergsten Ulrika , Klingberg Eva 
Published: May 2021

ObjectivesWe aimed to compare traditional (trad) cardiovascular risk factors (CVRFs) among patients with gout, psoriatic arthritis (PsA), rheumatoid arthritis (RA) and ankylosing spondylitis (AS) stratified by sex.MethodsA survey was sent to patients with gout (n=1589), PsA (n=1200), RA (n=1246) and AS (n=1095). Patients were retrieved from Sahlgrenska University Hospital, the hospitals of Uddevalla and Skövde, and 12 primary care centres in Western Sweden. The prevalence of self-reported trad-CVRFs was compared between diagnoses by age standardisation with the 2018 population of Sweden as the standard population.ResultsIn total, 2896 (56.5%) of 5130 patients responded. Hypertension was the most frequently found comorbidity, reported by 65% of patients with gout, 41% with PsA, 43% with RA and 29% with AS. After age standardisation, women and men with gout had significantly more obesity (body mass index ≥30 kg/m2), hypertension, diabetes, hyperlipidaemia and multiple trad-CVRFs, compared with those with PsA, RA and AS. Obesity was significantly more common in PsA than in RA. In women, obesity, hypertension and multiple trad-CVRFs were more frequently reported in PsA than in RA and AS, whereas similar prevalence of CVRFs and coexistence of multiple trad-CVRFs were found in men with PsA, RA and AS.ConclusionsWomen and men with gout had the highest prevalence of trad-CVRFs. Differences in occurrence of CVRFs by sex were found in patients with PsA, RA and AS. In women, patients with PsA had higher occurrence of trad-CVRFs than those with RA and AS, whereas in men the distribution of CVRFs was similar in PsA, RA and AS.
Short-term glucocorticoids reduce risk of chronic NSAID and analgesic use in early methotrexate-treated rheumatoid arthritis patients with favourable prognosis: subanalysis of the CareRA randomised controlled trial
Authors: Pazmino Sofia , Boonen Annelies , De Cock Diederik , Stouten Veerle , Joly Johan , Bertrand Delphine , Westhovens René , Verschueren Patrick 
Published: May 2021

ObjectiveTo explore non-steroidal anti-inflammatory drug (NSAID) and analgesic use in early rheumatoid arthritis (eRA) patients with a favourable risk profile initiating methotrexate (MTX) with or without glucocorticoid (GC) bridging.MethodsPatients with eRA (≤1 year) and favourable risk profile (no erosions, negative rheumatoid factor and anticitrullinated protein antibodiesor low disease activity) in the 2-year CareRA trial were randomised to MTX 15 mg with a step-down GC scheme (COBRA Slim), or MTX without oral GCs, Tight-Step-Up (TSU). Used analgesics were recorded, including frequency, start/end date and indication. Chronic intake (≥90 consecutive days in trial) of NSAIDs, acetaminophen, opioids including tramadol and antidepressants for the indication of musculoskeletal (MSK) pain was considered. Treatments were compared using χ2and analysis of variance with Holm’s correction for multiple testing.ResultsIn total, 43 patients were randomised to COBRA Slim and 47 to TSU. At study inclusion, 33/43 (77%) of patients in the COBRA Slim and 32/47 (68%) in the TSU arm had been using analgesics (p=0.5). During the trial, 67 NSAID and analgesics were used for MSK pain in 26/43 (60%) COBRA Slim patients of which 9/43 (21%) daily chronically (DC), while 107 NSAID and analgesics were used in 43/47 (92%) TSU patients, of which 25/47 (53%) DC. The total number of patients on NSAID and analgesics at any time during the study (p<0.01) and chronically (p=0.01) was significantly different between treatment arms. Number of patients on DC NSAIDs was also significantly different (p<0.01) between COBRA Slim 6/43 (14%) and TSU 19/47 (40%).ConclusionIn eRA patients considered to have a favourable prognosis, initial oral GC bridging resulted in lower chronic NSAID and analgesic use.Trial registration numberNCT01172639.
Tool to monitor tobacco control policy implementation: the Tobacco Control Scale in Latin America. Adaptation process and pilot study
Authors: Feliu Ariadna , Martinez Cristina , Peruga Armando , Joossens Luk , Bianco Eduardo , Cornejo Marco , Nogueira Sarah O , Fernández Esteve 
Published: May 2021

BackgroundMonitoring tobacco control policy implementation is one of the keys for tobacco consumption reduction in Latin America (LA). This study reports on the adaptation of the Tobacco Control Scale (TCS) for use in LA countries and the level of tobacco control policy implementation in this region according to the scale.MethodsEcological cross-sectional survey. The questionnaire to measure tobacco control policies was a translated (into Spanish and Portuguese) and adapted version of the last TCS as used in Europe. The resulting TCS-LA maintains the same structure as the original TCS, with eight policy domains and 100 points (pts) as maximum score; however, four policy domains were adapted because the exact same rationale could not be applied. At least two non-governmental tobacco control experts were contacted per country to answer the TCS-LA.ResultsInformants from 17 out of 18 countries completed the questionnaire. Using the TCS-LA, Panama (70 pts), Uruguay (68 pts) and Ecuador (61 pts) exhibited the strongest tobacco control policies, while Guatemala (32 pts), Bolivia (30 pts) and Dominican Republic (29 pts) have implemented a lower number of tobacco control policies. Eight countries reached 50% of the TCS-LA total possible score, indicating a relatively good implementation level of tobacco control policies.ConclusionsPanama, Uruguay and Ecuador are the tobacco control policy leaders in LA; however, tobacco control in the region has room for improvement since nine countries have a total score under 50 pts. The TCS is a feasible and adaptable tool to monitor tobacco control in other WHO regions beyond Europe.
Dorsal Plating for Specific Fracture Pattern of the Distal Radius
Authors: Boretto Jorge G. , Altube Gonzalo , Petrucelli Eliana , Zaidenberg Ezequiel E. , Gallucci Gerardo L. , De Carli Pablo 
Published: May 2021

Background: Volar locking plates have provided the capability to repair both simple and complex fractures. However, complications related to the inability to fix or to maintain the fixation of some fracture patterns have been reported with volar locking plates. The purpose of this study was to evaluate the results of dorsal plating treatment for specific pattern of fractures. Methods: Patients with distal radius fractures were retrospectively evaluated. Inclusion criteria for this study were those related to the patient and treatment (adult patients, internal fixation with dorsal plating, a minimum follow-up of 12 months), and those related to the fracture pattern (displaced central articular fragment, volar distal fracture line not enough to allow volar fixation, displaced dorsal-ulnar fragment, dorsal partial fractures, combination of these patterns). Clinical outcome information including active range of motion, radiographs, PRWE and DASH questionnaires were collected. Complications were recorded. Results: During a 6-year period, 679 distal radius fractures were treated with open reduction and internal fixation. Of these, 27 patients fulfilled the inclusion criteria. Patients were examined at a median of 34 months’ follow-up. All but pronation, supination, and radial deviation had a statistically significant difference compared to the opposite side. The median score on the DASH was 4.5 and 3.2 on the PRWE. No patient suffered loss of reduction during the follow-up nor were tendon ruptures recorded. Conclusions: Although most of the distal radius fractures can be treated with volar locking plates, almost 5% of them present specific patterns that are amenable to treatment with dorsal fixation, without postoperative loss of reduction. These specific patterns are: (1) displaced central articular fragment, (2) volar distal fracture with less of 1cm distance from the distal volar edge of the radius, (3) displaced dorso-ulnar fragment, (4) Barton’s fracture, (5) combination of these patterns.
Effect of Diabetes and Hemoglobin A1c on Complications Following Elective Hand Surgery
Authors: Del Core Michael A. , Benage Timothy C. , Ahn Junho , Koehler Daniel , Sammer Douglas , Golden Ann S. 
Published: May 2021

Background: Limited research exists investigating the association between diabetes and glycemic control on complications following elective hand surgery. The goal of this research was to assess the incidence of complications within 30 days of elective hand surgery in a large population of diabetic patients compared to a population of non-diabetics. Furthermore, we sought to examine the relationship of glycemic control, as measured by HbA1c, and postoperative complications. Methods: We performed a retrospective review of electronic medical records at our institution of all patients who underwent elective hand, forearm, or elbow surgery from the dates of January 1st, 2008 to December 31st, 2017. Patients were categorized as diabetic or non-diabetic and most recent HbA1c was documented. Multivariable analysis was employed to compare the incidence of surgical complications within 30 days between the diabetics and non-diabetic populations, adjusting for baseline patient characteristics. Results: A total of 3,261 patients met the inclusion criteria. There were 646 (20%) diabetic patients and 2,615 (80%) non-diabetic patients. No difference was found in the overall rate of complications between the cohort of diabetic and non-diabetic patients. Additionally, statistical analysis found no difference in the complication rate between insulin and non-insulin controlled diabetics. Rates of complications were stratified based on HbA1c level and statistical analysis found no increased risk of complications with increased hemoglobin A1c value. Conclusions: In our present study we were not able to demonstrate any significant difference in the 30 day complication rates between and non-diabetics undergoing elective hand surgery. This study attempted to aid in risk stratification of diabetic patients by evaluating preoperative glycemic indices in the form of HbA1c.
The search for unlimited productivity
Authors: Meil Doug 
Published: May 2021

The
Communications
website, http://cacm.acm.org, features more than a dozen bloggers in the BLOG@CACM community. In each issue of
Communications
, we'll publish selected posts or excerpts.

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Follow us on Twitter at http://twitter.com/blogCACM
http://cacm.acm.org/blogs/blog-cacm
Doug Meil considers the continuing search for the next great software development methodology.
Neuroendocrine Neoplasms of the Gallbladder: A Clinicopathological Analysis of 13 Patients and a Review of the Literature
Authors: Wang Pengyan , Chen Jingci , Jiang Ying , Jia Congwei , Pang Junyi , Wang Shan , Chang Xiaoyan 
Published: May 2021

Objectives. Mixed neuroendocrine–non-neuroendocrine neoplasms (MiNENs) are rare gallbladder neuroendocrine neoplasms (GB-NENs). This study is aimed at investigating the clinicopathological features of GB-NENs and identifying prognostic factors related to overall survival (OS) of GB-MiNENs. Methods. The clinical data and pathological features of 13 patients with GB-NENs in our hospital were retrospectively reviewed. Additionally, 41 GB-MiNENs cases reported in English literature were reviewed and survival analysis was performed. Results. The mean age of thirteen patients (6 males and 7 females) with GB-NENs was 57.2 years (range: 35-75 years). Two patients were diagnosed with NET grade 1 (G1), two patients with NEC (

large

cell
/
small

cell
=
1
/
1

), and nine patients with MiNENs. Of these 9 patients with MiNENs, 8 had composite tumors and 1 had amphicrine carcinoma. Microscopically, the adenocarcinoma component was located in the surface mucosa, and the neuroendocrine component was in the area of deep invasion, liver infiltration, and lymph node metastasis. Total analysis of 41 GB-MiNENs showed that patients were mainly elderly women (female/male ratio, 2.4 : 1.0; median age, 60 years). Kaplan-Meier’s analysis demonstrated that liver metastasis and TNM stage III-IV were associated with decreased OS (

P
<
0.05

), whereas age, sex, tumor size, grade of the neuroendocrine component, lymph node metastasis, and adjuvant chemotherapy were not significantly prognostic indicators of OS. Multivariate analysis identified liver metastasis (

hazard

ratio
=
4.262

,

95
%
confidence

interval
=
1.066
‐
17.044

,

P
=
0.040

) as an independent unfavorable prognostic factor. Conclusions. GB-MiNENs were the most common type of GB-NENs in our case series, and neuroendocrine components exhibited more aggressive lymph node metastasis and local invasion than adenocarcinoma. Liver metastasis was a poor prognostic indicator in GB-MiNENs patients.
A Novel Topical Fluorescent Probe for Detection of Glioblastoma
Authors: Kitagawa Yosuke , Tanaka Shota , Kamiya Mako , Kuriki Yugo , Yamamoto Kyoko , Shimizu Takenori , Nejo Takahide , Hana Taijun , Matsuura Reiko , Koike Tsukasa , Yamazawa Erika , Kushihara Yoshihiro , Takahashi Satoshi , Nomura Masashi , Takami Hirokazu , Takayanagi Shunsaku , Mukasa Akitake , Urano Yasuteru , Saito Nobuhito 
Published: May 2021

Abstract

Purpose:
Five-aminolevulinic acid (5-ALA) is widely used as an intraoperative fluorescent probe for radical resection of high-grade glioma, and thus aids in extending progression-free survival of patients. However, there exist some cases where 5-ALA fails to fluoresce. In some other cases, it may undergo fluorescence quenching but cannot be orally readministered during surgery. This study aimed to develop a novel hydroxymethyl rhodamine green (HMRG)-based fluorescence labeling system that can be repeatedly administered as a topical spray during surgery for the detection of glioblastoma.

Experimental Design:
We performed a three-stage probe screening using tumor lysates and fresh tumor tissues with our probe library consisting of a variety of HMRG probes with different dipeptides. We then performed proteome and transcript expression analyses to detect candidate enzymes responsible for cleaving the probe. Moreover, in vitro and ex vivo studies using U87 glioblastoma cell line were conducted to validate the findings.

Results:
The probe screening identified proline-arginine–HMRG (PR-HMRG) as the optimal probe that distinguished tumors from peritumoral tissues. Proteome analysis identified calpain-1 (CAPN1) to be responsible for cleaving the probe. CAPN1 was highly expressed in tumor tissues which reacted to the PR-HMRG probe. Knockdown of this enzyme suppressed fluorescence intensity in U87 glioblastoma cells. In situ assay using a mouse U87 xenograft model demonstrated marked contrast of fluorescence with the probe between the tumor and peritumoral tissues.

Conclusions:
The novel fluorescent probe PR-HMRG is effective in detecting glioblastoma when applied topically. Further investigations are warranted to assess the efficacy and safety of its clinical use.
The Failure to Protect in Myanmar: A Reflection on National Protection of Rohingya against Mass Atrocity Crimes and Prospects for the Responsibility to Protect
Authors: Diamond Nickey 
Published: May 2021

Abstract
Impunity has been a major cause of the atrocity crimes committed by the Myanmar military, and accountability is generally seen as a central component of R2P. This article traces the changes of attitudes towards R2P-related measures in Myanmar. After 2017, voices gradually emerged from within Myanmar civil society in support of R2P, influenced by international efforts to ensure accountability and documentation. However, this support mostly came from ethnic minority groups. In the broader population and political leadership, calls for R2P were met with general hostility. Since the February 2021 coup, there has been a dramatic change of attitudes towards R2P, at least within the protest movement. However, the growing calls for R2P often reflect a desire for international military intervention that is unlikely to happen. Moreover, domestic efforts to hold the military accountable are now even more unlikely. International action to push for accountability is therefore still needed.
Future changes in the frequency of extreme droughts over China based on two large ensemble simulations
Authors: Li Wei , Pan Rongyun , Jiang Zhihong , Chen Yang , Li Laurent , Luo Jing-Jia , Zhai Panmao , Shen Yuchen , Yu Jinhua 
Published: May 2021

AbstractFuture changes in the frequency of extreme drought events are of vital importance for risk assessment and relevant policy making. But a reliable estimation of their probability is intrinsically challenging due to limited available observations or simulations. Here, we use two large ensemble simulations, 50 members from CanESM2 and 40 members from CESM1 under the future RCP8.5 scenario, to elaborate a reliable projection of the 100-year drought events (once in a century) under different warming levels. It is however necessary to firstly remove systematic biases for the simulated temperature and precipitation through a bias-correction method based on quantile mapping. Droughts are diagnosed with the Standardized Precipitation Evapotranspiration Index (SPEI), which considers both precipitation and potential evapotranspiration (PET, involving temperature). The results show that the frequency of extreme droughts increases with the continued global warming. Some differences between the two ensembles are also observed, especially for high warming levels. The China-averaged probability of 100-year droughts that occur once in a century in the current climate increases by factors of 1.52 (1.90) and 1.44 (2.02) in the two ensembles under 1.5°C and 2°C warming levels, respectively. A simple statistical scheme shows that the increasing future risk of extreme droughts is mainly due to the increasing effect of PET on the occurrence of extreme drought events, while the effect of precipitation almost keeps constant with global warming.
Factors Controlling the Diversities of MJO Propagation and Intensity
Authors: Wang Tianyi , Li Tim 
Published: May 2021

AbstractThe diversity of the Madden-Julian Oscillation (MJO) in terms of its maximum intensity, zonal extent and phase speed was explored using a cluster analysis method. The zonal extent is found to be significantly correlated to the phase speed. A longer zonal extent is often associated with a faster phase speed.The diversities of zonal extent and speed are connected with distinctive interannual sea surface temperature anomaly (SSTA) distributions and associated moisture and circulation patterns over the equatorial Pacific. An El Niño–like background SSTA leads to enhanced precipitation over the central Pacific, allowing a stronger vertically overturning circulation to the east of the MJO. This promotes both a larger east-west asymmetry of column-integrated moist static energy (MSE) tendency and a greater boundary-layer moisture leading, serving as potential causes of the faster phase speed. The El Niño–like SSTA also favors the MJOs intruding further into the Pacific, causing a larger zonal extent.The intensity diversity is associated with the interannual SSTA over the Maritime Continent and background moisture condition over the tropical Indian Ocean. An observed warm SSTA over the Maritime Continent excites a local Walker cell with a subsidence over the Indian Ocean, which could decrease the background moisture, weakening the MJO intensity. The intensity difference between strong and weak events would be amplified due to distinct intensity growth speed. The faster intensity growth of a strong MJO is attributed to a greater longwave radiative heating and a greater surface latent heat flux, as both of which contribute to a greater total time change rate of the column-integrated MSE.
Improving Signal Statistics Using a Regression Ground Clutter Filter. Part 1: Theory and Simulations
Authors: Hubbert J.C. , Meymaris G. , Romatschke U. , Dixon M. 
Published: May 2021

AbstractGround clutter filtering is an important and necessary step for quality control of ground-based weather radars. In this two-part paper ground clutter mitigation is addressed using a time-domain regression filter. Clutter filtering is now widely accomplished with spectral processing where the times series of data corresponding to a radar resolution volume are transformed with a Discrete Fourier Transform after which the zero and near-zero velocity clutter components are eliminated by setting them to zero. Subsequently for reectivity, velocity and spectrum width estimates, interpolation techniques are used to recover some of the power loss due to the clutter filter, which has been shown to reduce bias. The spectral technique requires that the I (in-phase) and Q (quadrature) time series be windowed in order to reduce clutter power leakage away from zero and near-zero velocities. Unfortunately, window functions such as the Hamming, Hann and Blackman attenuate the time series signal by 4.01, 4.19 and 5.23 dB for 64-point times series, respectively, and thereby effectively reduce the number of independent samples available for estimating the radar parameters of any underlying weather echo. Here in Part 1 a regression filtering technique is investigated, via simulated data, which does not require the use of such window functions and thus provides for better weather signal statistics. In Part 2 (Hubbert et al. 2021) the technique is demonstrated using both S-Pol and NEXRAD data. It is shown that the regression filter rejects clutter as effectively as the spectral technique but has the distinct advantage that estimates of the radar variables are greatly improved. The technique is straightforward and can be executed in real time.