bluuebunny/crossref_metadata_2025_split huggingface dataset:
FSR and IMU sensors-based human gait phase detection and its correlation with EMG signal for different terrain walk
Authors: Negi Sachin , Sharma Shiru , Sharma Neeraj 
Published: May 2021

Purpose
The purpose of this paper is to present gait analysis for five different terrains: level ground, ramp ascent, ramp descent, stair ascent and stair descent.

Design/methodology/approach
Gait analysis has been carried out using a combination of the following sensors: force-sensitive resistor (FSR) sensors fabricated in foot insole to sense foot pressure, a gyroscopic sensor to detect the angular velocity of the shank and MyoWare electromyographic muscle sensors to detect muscle’s activities. All these sensors were integrated around the Arduino nano controller board for signal acquisition and conditioning purposes. In the present scheme, the muscle activities were obtained from the tibialis anterior and medial gastrocnemius muscles using electromyography (EMG) electrodes, and the acquired EMG signals were correlated with the simultaneously attained signals from the FSR and gyroscope sensors. The nRF24L01+ transceivers were used to transfer the acquired data wirelessly to the computer for further analysis. For the acquisition of sensor data, a Python-based graphical user interface has been designed to analyze and display the processed data. In the present paper, the authors got motivated to design and develop a reliable real-time gait phase detection technique that can be used later in designing a control scheme for the powered ankle-foot prosthesis.

Findings
The effectiveness of the gait phase detection was obtained in an open environment. Both off-line and real-time gait events and gait phase detections were accomplished for the FSR and gyroscopic sensors. Both sensors showed their usefulness for detecting the gait events in real-time, i.e. within 10 ms. The heuristic rules and a zero-crossing based-algorithm for the shank angular rate correctly identified all the gait events for the locomotion in all five terrains.

Practical implications
This study leads to an understanding of human gait analysis for different types of terrains. A real-time standalone system has been designed and realized, which may find application in the design and development of ankle-foot prosthesis having real-time control feature for the above five terrains.

Originality/value
The noise-free data from three sensors were collected in the same time frame from both legs using a wireless sensor network between two transmitters and a single receiver. Unlike the data collection using a treadmill in a laboratory environment, this setup is useful for gait analysis in an open environment for different terrains.
The effects of COVID-19 on Andalusian tourism and aviation sector
Authors: Florido-Benítez Lázaro 
Published: May 2021

Purpose
This study aims to analyze the effects of COVID-19 on airlines, airports and the destination Andalusia. On that basis, the study has assessed the bankruptcy of some airlines, closure and reduction of the frequency of air routes, COVID-19 measures at airports by governments, etc., to adapt to new circumstances, be efficient and plan their resources according to the tourist demand.

Design/methodology/approach
A review of the relevant literature on the impact of COVID-19 on the aviation industry, airports and tourism sector are undertaken to understand the link between them. The paper begins by explaining the effects of the pandemic on the aviation industry and discusses its impact in the Andalusian region. Furthermore, this study uses secondary data from IATA, AENA, EUROCONTROL, INE, OAG, UNTWO, etc., to support research results.

Findings
The results of the effects of the pandemic in Andalusia are being devastating and this destination is heavily dependent on tourism. The drastic drop in flight frequencies at airports during the pandemic has caused an average decrease of −65% in passenger arrivals at airports until October 2020 that is 23 million passengers, too many passengers for the Andalusian economy, which depends mainly on the tourism sector.

Originality/value
The study contributes toward assessing the COVID-19 effects on the aviation industry and tourist destinations. Both sectors will re-emerge in the medium term and at different speeds in different regions. The contribution of this study is essential for managers and operators of airlines, airports and tourist destinations to make better future decisions.
Can passive pedaling improve sexual function in patients under hemodialysis? A randomized clinical trial
Authors: Salehi Farzaneh , Mangolian Shahrbabaki Parvin , Dehghan Mahlagha , Amirihosseini Mojdeh 
Published: May 2021

AbstractTo investigate the effect of passive pedaling with mini bike on sexual function in patients under hemodialysis. This study was a randomized clinical trial. Thirty‐seven patients undergoing hemodialysis were assigned to the intervention (n = 20) and control (n = 17) groups by the stratified block randomization method. The intervention group exercised with a mini bike that was automatic and tuned for patients during the first 2 h of dialysis, twice a week for 20 min each time, for 3 months. The International Index of Erectile Function and Female Sexual Function Index were used to assess the sexual function in the first, second, and third months during the intervention and one month after the intervention. A higher score indicates a better sexual function. Repeated measure ANOVA, Chi–square and Fisher exact tests, independent t, and Mann–Whitney U tests were used for data analysis. The SPSS software version 22 was used for data analysis. Sexual function scores of the intervention group were 35.9 at the beginning of the study, 34.1 in the first month, 37.4 in the second month, 34.8 in the third month, and 31.7 one month after the study. There was no significant difference in the scores of sexual function in the intervention group during the study. The mean scores of sexual function in the control group were 34.5, 34.4, 34.9, 33.8, and 33.9 at the beginning of the study, in the first month, in the second month, in the third month, and one month after the study, respectively (p > 0.05). There was no significant difference between the two groups in terms of sexual function scores during and after the intervention (p > 0.05). Passive pedaling with mini‐bike had no effect on sexual function of hemodialysis patients.
Hospital competition and quality for non‐emergency patients in the English NHS
Authors: Moscelli Giuseppe , Gravelle Hugh , Siciliani Luigi 
Published: May 2021

AbstractWe investigate the effect on the quality of three high‐volume non‐emergency treatments of a reform that relaxed restrictions on patient choice of hospital. We employ a quasi difference‐in‐difference strategy and use control functions allowing for patient selection into providers correlated with unobserved morbidity. Public hospitals facing more rivals reduced quality, increased waiting times, and reduced length of stay for hip and knee replacements. This is likely due to regulated prices implying larger losses on these treatments compared to coronary artery bypass grafts, where no effects were found. Our findings are robust to estimation methods and competition measures, allowing for private providers’ entry.
Can novel ‘swift‐certain‐fair’ programs work outside of pioneering jurisdictions? An analysis of 24/7 Sobriety in Montana, USA
Authors: Midgette Greg , Kilmer Beau 
Published: May 2021

AbstractBackground and AimsThe US state of South Dakota's 24/7 Sobriety Program (24/7) requires individuals charged or convicted of alcohol‐involved offenses to avoid alcohol and submit to twice‐daily or continuous alcohol testing. We evaluated the impact of the 24/7 program in the US state of Montana.MethodsUsing data from everyone in Montana who was convicted of their second driving under the influence (DUI) offense from 2009 to August 2013, we described program violations among 24/7 participants and then estimated the effect of 24/7 participation on the probability of DUI re‐arrest. To address potential selection issues related to individual‐level 24/7 participation, we used an instrumental variables approach that exploits county‐level variation in program adoption.ResultsAmong 2768 people convicted of a second DUI in our analytical sample, 356 participated in 24/7 and were monitored for an average of 173 days (median = 112 days). Among the 332 participants monitored by breath test, 95.5% of scheduled alcohol breath tests were completed and did not lead to a program violation. After controlling for individual‐ and community‐level covariates as well as year and county fixed effects, our instrumental variable models suggested that participation in 24/7 reduced the 1‐year DUI re‐arrest probability by at least 80% (preferred model: 86% decrease; 8.9 percentage points) compared with a counterfactual group of people convicted of a second DUI over the same period but not assigned to the program.ConclusionsSouth Dakota USA's 24/7 Sobriety Program appears to work in Montana as well. Certain delivery of immediate but modest sanctions for repeat driving under the influence (DUI) arrestees who violate alcohol abstinence orders appears to be able to reduce future DUI arrests.
Association between mucosal barrier disruption by Pseudomonas aeruginosa exoproteins and asthma in patients with chronic rhinosinusitis
Authors: Tuli Jannatul Ferdoush , Ramezanpour Mahnaz , Cooksley Clare , Psaltis Alkis James , Wormald Peter‐John , Vreugde Sarah 
Published: May 2021

AbstractBackgroundChronic rhinosinusitis (CRS) is a common chronic respiratory condition, frequently associated with asthma and affecting the majority of cystic fibrosis (CF) patients. Pseudomonas aeruginosa infections and biofilms have been implicated in recalcitrant CRS. One of the mechanisms of action for bacteria in CRS and CF is mucosal barrier disruption by secreted products that contribute to the inflammation. However, the role of biofilm and planktonic forms of P. aeruginosa in this process is not known. The aim is to determine the effect of P. aeruginosa exoproteins isolated from CF and non‐CF CRS patients on the mucosal barrier.MethodsExoproteins from 40 P. aeruginosa isolates were collected in planktonic and biofilm forms and applied to air‐liquid interface (ALI) cultures of primary human nasal epithelial cells (HNECs). Mucosal barrier integrity was evaluated by transepithelial electrical resistance (TEER), passage of FITC‐dextrans and immunofluorescence of tight junction proteins. Cytotoxicity assays were performed to measure cell viability, and IL‐6 ELISA was carried out to evaluate pro‐inflammatory effects.ResultsPlanktonic exoproteins from 20/40 (50%) clinical isolates had a significant detrimental effect on the barrier and significantly increased IL‐6 production. Barrier disruption was characterized by a reduced TEER, increased permeability of FITC‐dextrans and discontinuous immunolocalization of tight junction proteins and was significantly more prevalent in isolates harvested from patients with comorbid asthma (P < .05).ConclusionExoproteins from planktonic P. aeruginosa clinical isolates from asthmatic CRS patients have detrimental effects on the mucosal barrier and induce IL‐6 production potentially contributing to the mucosal inflammation in CRS patients.
Efficacy of patient selection criteria for obesity surgery in a non‐high‐dependency unit/intensive care unit facility
Authors: Newbold Ryan , Craven Alexander , Aly Ahmad 
Published: May 2021

AbstractBackgroundsPublicly funded obesity surgery remains underfunded in Australia. One barrier to expansion is the perception that perioperative care requires critical care facilities. This study evaluates the effectiveness of patient selection criteria in avoiding unplanned patient transfer and adverse outcomes in obesity surgery performed at a facility without a high‐dependency unit/intensive care unit (HDU/ICU).MethodsRetrospective analysis was performed on patients undergoing obesity surgery between January 2017 and March 2020 in a centre with specific screening criteria. Criteria included: body mass index <48 for males and <52 for females with up to three stable comorbidities from a selected list. Revision sleeve or bypass procedures were contraindicated. Primary outcome was patient transfer to our main campus. Secondary outcomes included return to theatre (RTT), readmission and death. Outcomes were compared to laparoscopic cholecystectomies (LC) performed at the same centre.ResultsA total of 387 obesity surgery procedures were performed; 372 patients (96%) were discharged without complication. Fifteen (3.9%) were transferred to the main campus, eight were admitted to ICU and two required re‐operation. Twelve (3.1%) were readmitted within 30 days of discharge, five required re‐operation. Transfer, 30‐day readmission and 30‐day emergency department presentation rates were similar in comparison to LC. RTT during index admission (0.5% vs. 3.0%; p = 0.006) and during 30‐day post‐operative period (1.8% vs. 4.4%; p = 0.025) was lower in the obesity surgery group.ConclusionCarefully selected screening criteria allow obesity surgery to be performed at a well‐supported non‐HDU/ICU facility with few complications and acceptable rates of unplanned patient transfer.
Recurrence, postponing pregnancy, and termination rates after hyperemesis gravidarum: Follow up of the MOTHER study
Authors: Nijsten Kelly , Dean Caitlin , van der Minnen Loïs M. , Bais Joke M. J. , Ris‐Stalpers Carrie , van Eekelen Rik , Bremer Henk A. , van der Ham David P. , Heidema Wieteke M. , Huisjes Anjoke , Kleiverda Gunilla , Kuppens Simone M. , van Laar Judith O. E. H. , Langenveld Josje , van der Made Flip , Papatsonis Dimitri , Pelinck Marie‐José , Pernet Paula J. , van Rheenen‐Flach Leonie , Rijnders Robbert J. , Scheepers Hubertina C. J. , Vogelvang Tatjana , Mol Ben W. , Roseboom Tessa J. , Koot Marjette H. , Grooten Iris J. , Painter Rebecca C. 
Published: May 2021

AbstractIntroductionHyperemesis gravidarum (HG) complicates 1% of pregnancies and has a major impact on maternal quality of life and well‐being. We know very little about HG’s long‐term impact after an affected pregnancy, including recurrence rates in future pregnancies, which is essential information for women considering subsequent pregnancies. In this study, we aimed to prospectively measure the recurrence rate of HG and the number of postponed and terminated subsequent pregnancies due to HG. We also aimed to evaluate if there were predictive factors that could identify women at increased risk for HG recurrence, and postponing and terminating subsequent pregnancies.Material and methodsWe conducted a prospective cohort study. A total of 215 women admitted for HG to public hospitals in the Netherlands were enrolled in the original MOTHER randomized controlled trial and associated observational cohort. Seventy‐three women were included in this follow‐up study. Data were collected through an online questionnaire. Recurrent HG was defined as vomiting symptoms accompanied by any of the following: multiple medication use, weight loss, admission, tube feeding or if nausea and vomiting symptoms were severe enough to affect life and/or work. Outcome measures were recurrence, postponing, and termination rates due to HG. Univariable logistic regression analysis was used to identify predictive factors associated with HG recurrence, and postponing and terminating subsequent pregnancies.ResultsThirty‐five women (48%) became pregnant again of whom 40% had postponed their pregnancy due to HG. HG recurred in 89% of pregnancies. One woman terminated and eight women (23%) considered terminating their pregnancy because of recurrent HG. Twenty‐four out of 38 women did not get pregnant again because of HG in the past. Univariable logistic regression analysis identifying possible predictive factors found that having a western background was associated with having weight loss due to recurrent HG in subsequent pregnancies (odds ratio 12.9, 95% CI 1.3–130.5, p = 0.03).ConclusionsHigh rates of HG recurrence and a high number of postponed pregnancies due to HG were observed. Women can be informed of a high chance of recurrence to enable informed family planning.
TRPV3 and TRPV4 as candidate proteins for intestinal ammonium absorption
Authors: Manneck David , Braun Hannah‐Sophie , Schrapers Katharina T. , Stumpff Friederike 
Published: May 2021

AbstractAimAbsorption of ammonia from the gut has consequences that range from encephalitis in hepatic disease to global climate change induced by nitrogenous excretions from livestock. Since patch clamp data show that certain members of the transient receptor potential (TRP) family are permeable to NH4+, participation in ammonium efflux was investigated.MethodsDigesta, mucosa and muscular samples from stomach, duodenum, jejunum, ileum, caecum and colon of pigs were analysed via colourimetry, qPCR, Western blot, immunohistochemistry and Ussing chambers.ResultsqPCR data show high duodenal expression of TRPV6. TRPM6 was highest in jejunum and colon, with expression of TRPM7 ubiquitous. TRPM8 and TRPV1 were below detection. TRPV2 was highest in the jejunum but almost non‐detectable in the colon. TRPV4 was ubiquitously expressed by mucosal and muscular layers. TRPV3 mRNA was only found in the mucosa of the caecum and colon, organs in which NH4+ was highest (>7 mmol·L−1). Immunohistochemically, an apical expression of TRPV3 and TRPV4 could be detected in all tissues, with effects of 2‐APB and GSK106790A supporting functional expression. In symmetrical NaCl Ringer, removal of mucosal Ca2+ and Mg2+ increased colonic short circuit current (Isc) and conductance (Gt) by 0.18 ± 0.06 µeq·cm−2·h−1 and 4.70 ± 0.85 mS·cm−2 (P < .05, N/n = 4/17). Application of mucosal NH4Cl led to dose‐dependent and divalent‐sensitive increases in Gt and Isc, with effects highest in the caecum and colon.ConclusionWe propose that TRP channels contribute to the intestinal transport of ammonium, with TRPV3 and TRPV4 promising candidate proteins. Pharmacological regulation may be possible.
Adhering to COVID‐19 health guidelines: Examining demographic and psychological predictors of adherence
Authors: Bailey Brooklynn , Whelen Megan L. , Strunk Daniel R. 
Published: May 2021

AbstractThe effort to limit the spread of the coronavirus (COVID‐19) has relied heavily on the general public's compliance with health guidelines limiting social contact and mitigating risk when contact occurs. The aim of this study was to identify latent variables underlying adherence to COVID‐19 guidelines and to examine demographic and psychological predictors of adherence. A sample of US adults (N = 1,200) were surveyed in late April to mid‐May 2020. The factor structure of adherence was examined using exploratory factor analysis. Machine learning regression models using elastic net regularization were used to examine predictors of adherence. Two factors characterized adherence: avoidance and cleaning. Elastic net models identified differential demographic and psychological predictors of these two forms of adherence. Religious affiliation, denial coping, full‐time employment, substance use coping, and being 60 or older predicted lower avoidance adherence. Behavioral and mindfulness emotion regulation skills, agreeableness, and Democrat political affiliation predicted greater avoidance adherence. For cleaning adherence, interpersonal and behavioral emotion regulation skills and conscientiousness emerged as strong predictors of greater cleaning. Efforts to promote compliance with COVID‐19 health guidelines may benefit from distinguishing avoidance and cleaning adherence and considering predictors of each of these aspects of adherence.
Autonomous but not isolated: A petrographic study of Iron Age ceramics from a ‘deep‐rural’ community in Asturias (NW Iberia)
Authors: de Groot Beatrijs G. , González‐Álvarez David 
Published: May 2021

AbstractThis article discusses a petrographic study of Late Iron Age (400–19 BCE) ceramics from El Castru in Vigaña (Asturias, NW Spain), providing evidence, for the first time in this region and time period, for the circulation of ceramics across NW Iberia. This preliminary study comprises the petrographic analysis of 40 pottery sherds and nine geological samples in order to discuss the mineralogical composition of the ceramic fabrics. The results point to a non‐local origin of most samples, providing the basis of a re‐examination of traditional views on the self‐sufficiency and isolation of Iron Age communities in Asturias during the Late Iron Age.
Triploid pregnancy–Clinical implications
Authors: Massalska Diana , Bijok Julia , Kucińska‐Chahwan Anna , Zimowski Janusz Grzegorz , Ozdarska Katarzyna , Panek Grzegorz , Roszkowski Tomasz 
Published: May 2021

AbstractTriploidy is a life‐limiting genetic aberration resulting from an extra haploid set of chromosomes of paternal (diandric triploidy) or maternal origin (digynic triploidy). Triploidy affects around 1%–2% of all conceptions. The majority of cases is miscarried at early developmental stages. In consequence of genomic imprinting, parental origin affects the phenotype of triploid pregnancies as well as the prevalence and spectrum of related maternal complications. Distinctive ultrasound features of both triploid phenotypes as well as characteristic patterns of biochemical markers may be useful in diagnosis. Molecular confirmation of the parental origin allows to predict the risk of complications, such as gestational trophoblastic neoplasia, hyperthyroidism, hypertension, or preeclampsia associated with the paternal origin of triploidy. Diagnosis of partial hydatidiform mole associated with diandric triploidy is challenging especially in the first trimester pregnancy loss due to the limitations of both histopathology and ultrasound. We present important clinical aspects of triploid pregnancies and indicate unresolved issues demanding further studies.
EZH2‐mediated inhibition of KLF14 expression promotes HSCs activation and liver fibrosis by downregulating PPARγ
Authors: Du Zhipeng , Liu Mei , Wang Zhihui , Lin Zhuoying , Feng Yangyang , Tian Dean , Xia Limin 
Published: May 2021

AbstractObjectivesInduction of deactivation and apoptosis of hepatic stellate cells (HSCs) are principal therapeutic strategies for liver fibrosis. Krüppel‐like factor 14 (KLF14) regulates various biological processes, however, roles, mechanisms and implications of KLF14 in liver fibrosis are unknown.Materials and MethodsKLF14 expression was detected in human, rat and mouse fibrotic models, and its effects on HSCs were assessed. Chromatin immunoprecipitation assays were utilized to investigate the binding of KLF14 to peroxisome proliferator‐activated receptor γ (PPARγ) promoter, and the binding of enhancer of zeste homolog 2 (EZH2) to KLF14 promoter. In vivo, KLF14‐overexpressing adenovirus was injected via tail vein to thioacetamide (TAA)‐treated rats to investigate the role of KLF14 in liver fibrosis progression. EZH2 inhibitor EPZ‐6438 was utilized to treat TAA‐induced rat liver fibrosis.ResultsKLF14 expression was remarkably decreased in human, rat and mouse fibrotic liver tissues. Overexpression of KLF14 increased LD accumulation, inhibited HSCs activation, proliferation, migration and induced G2/M arrest and apoptosis. Mechanistically, KLF14 transactivated PPARγ promoter activity. Inhibition of PPARγ blocked the suppressive role of KLF14 overexpression in HSCs. Downregulation of KLF14 in activated HSCs was mediated by EZH2‐regulated histone H3 lysine 27 trimethylation. Adenovirus‐mediated KLF14 overexpression ameliorated TAA‐induced rat liver fibrosis in PPARγ‐dependent manner. Furthermore, EPZ‐6438 dramatically alleviated TAA‐induced rat liver fibrosis. Importantly, KLF14 expression was decreased in human with liver fibrosis, which was significantly correlated with EZH2 upregulation and PPARγ downregulation.ConclusionsKLF14 exerts a critical anti‐fibrotic role in liver fibrosis, and targeting the EZH2/KLF14/PPARγ axis might be a novel therapeutic strategy for liver fibrosis.