bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-World Effectiveness of A Digital-Based Coaching Intervention for Cancer Survivors with Job Loss
Authors: Lo Jonathon , Ballurkar Kieran , Fox Simonie , Tynan kate , Luu Nghiep , Boyer Michael , Murali-Ganesh Raghav 
Published: July 2021

Abstract
Purpose:Return-to-work (RTW) is a key unmet need for working age cancer survivors. This study sought to evaluate RTW outcomes of a multidisciplinary intervention provided as routine employee support.Method:In a retrospective cohort analysis, patients with cancer and more than 3 months absent from work were provided an intervention consisting of digital resources and calls with a health coach. A logit regression model was used to calculate a propensity score using covariates of age, gender, insurance benefit type, date of cancer diagnosis and time from diagnosis derived from insurance-claims data and captured as standard business practice. Participants were matched on a 1:1 basis using the nearest-neighbor method without replacement to create a matched control group from a further 1,856 participants who did not receive the intervention.Results:220 participants enrolled in the intervention, of which 125 met the criteria for analysis. The median follow-up from cancer diagnosis was 79 weeks (IQR 60-106). In the matched control group, 22 returned to work (17.6%) compared with 38 (30.4%) in the intervention group (P=.02). Nineteen matched controls died prior to claim closure (15.2%) compared with 13 in the intervention group (10.4%; P=.26). Cox model estimated median time for the first 15% of the cohorts to RTW was 87.1 weeks for the matched control (CI 60.0-109.1 weeks) compared with 70.6 weeks for the intervention (CI 52.6-79.6 weeks; P=.08).Conclusion:A digitally delivered coaching program in a real-world setting for patients diagnosed with cancer improves the likelihood of RTW.Implications for cancer survivors: a remotely delivered coaching program in a real-world setting for cancer survivors can improve the likelihood of RTW.
Traditional Chinese Exercises for Chronic Diseases: Protocol for An Overview of Systematic Reviews and Meta-analyses
Authors: Zhang Fan , Bai Yan , Zhao Xing , Wang Hui , Zhou Wenqin , Zhang Huachun 
Published: July 2021

Abstract
Background: In recent years, increasing systematic reviews and meta-analyses about traditional Chinese exercises on chronic disease have been conducted. The main aim of this overview will be to appraise and synthesize these results. Methods A comprehensive review of the literature will be performed in the PubMed, Cochrane Database of Systematic Reviews, Embase, and Web of Science Core Collection, with the MeSH terms and keywords. Systematic reviews and meta-analyses of clinical trials evaluating the effectiveness of traditional Chinese exercises for patients with chronic disease will be included. Two independent authors will screen the titles and abstracts, and full-text articles will be identified. Relevant data will be extracted and tabulated. A Measurement Tool to Assess Systematic Reviews and the Grading of Recommendations Assessment, Development and Evaluation system will be used to assess the methodological quality and level of evidence of included reviews, respectively.Discussion: The overview will identify both the scientific and clinical importance of traditional Chinese exercises, and these findings will provide practical implications for patients, clinicians, professionals, and policymakers.Systematic review registration: PROSPERO CRD42021248444
Identification of Potential Signal Pathways and Immune Disorders in Crohn's Disease
Authors: zou qiyuan , Long Weiyan , Lv Xiaodan , Liu Gengfeng , Chen Ruyan , Zhan Lingling , Lv Xiaoping 
Published: July 2021

Abstract
Background: In recent years, the number of visits to Crohn's disease (CD) has gradually increased, but its pathogenesis is still unclear1.This research aimed to explore the potential molecular pathways and immune disorders of CD.Methods:The two gene datasets of GSE83448 and GSE95095 were used to identify differentially expressed genes (DEGs) in our study. We also carried out the function enrichment analyses of DEGs between the CD group and the control group.xCell is used to identify the types of lymphocytes in the microenvironment. Subsequently, the correlation analysis between potential enrichment pathways and lymphocyte infiltration in the microenvironment was performed. We mined 944 DEGs (321 up-regulated and 623 down-regulated) and 1467 DEGs (781 up-regulated and 686 down-regulated) in the GSE83448 and GSE95095 datasets, respectively. Results: Comprehensive analysis shows that: the Focal adhesion and ECM−receptor interaction are the main significant enrichment pathways. xCell analysis identified significantly altered immune cells in CD, Th17cells, included pDC, Th1cells, Blood vessels, Macrophages, NK CD56dim cells, Tem, NK cells, NK CD56bright cells, Lymph vessels. The enrichment scores of Focal adhesion and ECM-receptor interaction signaling pathways in the CD intestinal mucosa were significantly correlated with the abundance of immune cells in the two sets of data. Conclusions:These data suggest the important role of Focal adhesion and ECM-receptor interaction signal transduction pathways in CD, and the intimate relationship between these two pathways and specific types of immune cell infiltration.This study confirmed the potential molecular pathways and immune disorders in CD.
Risk Evaluation of Denosumab And Zoledronic Acid For Medication-Related Osteonecrosis of The Jaw In Patients With Bone Metastases: A Propensity Score-Matched Analysis
Authors: Ikesue Hiroaki , Doi Kohei , Morimoto Mayu , Hirabatake Masaki , Muroi Nobuyuki , Yamamoto Shinsuke , Takenobu Toshihiko , Hashida Tohru 
Published: July 2021

Abstract
Purpose: This study evaluated the risk of medication-related osteonecrosis of the jaw (MRONJ) in patients with cancer who received denosumab or zoledronic acid (ZA) for treating bone metastasis.Methods: The medical records of patients were retrospectively reviewed. Patients who did not undergo a dental examination at baseline were excluded. The primary endpoint was a comparison of the risk of developing MRONJ between the denosumab and ZA groups. Propensity score matching was used to control for baseline differences between patient characteristics and compare outcomes for both groups.Results: Among the 799 patients enrolled, 58 (7.3%) developed MRONJ. The incidence of MRONJ was significantly higher in the denosumab group than in the ZA group (9.6% [39/406] vs. 4.8% [19/393], p = 0.009). Multivariate Cox proportional hazards regression analysis revealed that denosumab treatment (hazard ratio [HR], 2.89; 95% confidence interval [CI], 1.65–5.25; p < 0.001) and tooth extraction after starting ZA or denosumab (HR, 4.26; 95% CI, 2.38–7.44; p < 0.001) were significant risk factors for MRONJ. Propensity score-matched analysis confirmed that the risk of developing MRONJ was significantly higher in the denosumab group than in the ZA group (HR, 2.34; 95% CI, 1.17–5.01; p = 0.016). Conclusion: The results of this study suggest that denosumab poses a significant risk for developing MRONJ in patients treated for bone metastasis, and thus these patients require close monitoring.
Combining Ability And Nature of Gene Effects Controlling Seed Yield And Its Component Traits In Alien Cytoplasm Based Hybrids In Sunflower (Helianthus Annuus L.)
Authors: Sharma Manish , Y.G.SHADAKSHARI  
Published: July 2021

Abstract
The present research aimed to study gene effects for seed yield and its component traits in sunflower hybrids having diverse cytosterile sources from Helianthus annuus and H. argophyllus. Five lines and ten testers were crossed in a line x tester mating design to develop 50 F1 hybrids for genetic analysis. The analysis of variance revealed significant differences among the traits studied. Seasonal variation was found significant for all the traits except stem diameter, volume weight and seed filling percentage. The mean squares of lines and testers from crosses both determine the GCA were also significant for most of the traits which revealed the prevalence of additive variances and additive gene action. The mean squares of lines x tester interactions were also significant for all the traits considered. The significance of lines x tester interactions indicated that SCA is also important in the expression of traits and demonstrated the value of non-additive variances and dominant genes controlling the various traits. Among the diverse cytosterile lines, ARG-6-3-1-4 was identified as the best general combiner for stem diameter, volume weight, seed yield, hull content, oil content and oil yield. While, the line ARG-2-1-2 was best general combiner for days to 50 per cent flowering, head diameter, 100 seed weight and seed filling percentage. The tester M17-R was observed to be best general combiner for earliness and volume weight, while RHA 93 was the best general combiner for plant height, seed yield and oil content. The best cross combinations; MUT-2-8-3-2 x GKVK 3 was found to be good specific combiner for stem diameter, 100 seed weight, seed yield, seed filling percentage, oil content and oil yield, while ARG-6-3-1-4 x GKVK 3 was good specific combiner for days to 50% flowering, plant height and 100 seed weight.
Sensing the lightness: a narrative analysis of an integrative medicine program for healthcare providers in the COVID-19 department
Authors: Ben-Arye Eran , Zohar Shaked , Keshet Yael , Gressel Orit , Samuels Noah , Eden Arieh , Vagedes Jan , Kassem Sameer 
Published: July 2021

Abstract
Objectives
There is limited research addressing physical and emotional exhaustion among healthcare providers (HCPs) in COVID-19 departments. We examined the impact of an integrative medicine (IM) intervention for HCPs working in isolated COVID-19 in-patient departments, addressing concerns and wellbeing.
Methods
HCPs working in 3 isolated COVID-19 in-patient departments underwent 40-minute IM treatment sessions (including acupuncture, manual-movement and/or mind-body modalities) provided by integrative oncology practitioners. The MYCAW (Measure Yourself Concerns and Well-being) questionnaire was used to address the two leading concerns and post-treatment reflections and narrative. Data were qualitatively analyzed using ATLAS.Ti software for systematic coding.
Results
A total of 181 HCPs underwent 305 IM treatments. Narrative themes focused on physical symptoms (primarily pain and fatigue) and emotional concerns, including perceived communication barriers with patients; and reflections on wellbeing and insights following IM treatments. HCPs reported feeling a sense of "relief" which was likely related to the 3 main effects of the IM intervention: a sense of "being cared for" and treated; experiencing emotional, sometimes spiritual effects of the treatment; and the feeling of relaxation, combined with the relief of pain. Qualitative analysis identified clusters of emotional and spiritual-related keywords such as "calming", "release", "relaxation” and “disengagement” following the first IM session (119 of 181 narratives, 65.7%).
Conclusions
HCPs working in isolated COVID-19 departments reported improved wellbeing and the addressing of their concerns following IM treatment sessions provided during their work shift. Further research is needed to explore the impact of IM on HCPs burnout and resilience in palliative care settings.
Seismic Behavior Investigations of the Haunched Joint with Ribbed Anchor Webs in CFDST Structures
Authors: zhang yufen , Bu Hongfan , Cao Shengxi 
Published: July 2021

Abstract
The haunched joint with ribbed anchor webs in the concrete-filled double steel tubular (CFDST) structure was proposed in this study. The CFDST column and the steel beam were connected by vertical ribbed webs, which were anchored inside the column and connected to the beam web by the bolted connection, and haunches were welded to shift plastic hinges from the joint core to beam ends. The cyclic loading test was conducted on three beam-to-column joint specimens. Seismic behaviors including failure modes, strain and stress responses, hysteretic curves, ductility, and energy dissipation capacity were respectively analyzed. Besides, a finite element (FE) modeling was completed by ABAQUS in consideration of geometric and material nonlinearity. The validity of FE modeling was checked by comparisons between FE results and test results, and research results confirmed that the beam-to-column rotation and the shear deformation in the joint core were small owing to the restriction from the configuration of haunches. Then parametric investigations on connection constructional details, geometric dimensions, material strength, and axial compression ratios, were made to study seismic behaviors of the haunched joint with ribbed anchor webs. It showed that the selected parameters except concrete strength had certain influences on bearing capacity, ductility, and energy dissipation, and corresponding practicable design suggestions were proposed for the application of haunched joints with ribbed anchor webs in CFDST structures.
Study of the Contribution of Active Defense Mechanisms to Ciprofloxacin Tolerance in Escherichia Coli Growing at Different Rates
Authors: Smirnova Galina , Tyulenev Aleksey V. , Muzyka Nadezda G. , Oktyabrsky Oleg N. 
Published: July 2021

Abstract
Using rpoS, tolC, ompF, and recA knockouts, we investigated their effect on the physiological response and lethality of ciprofloxacin in E. coli growing at different rates on glucose, succinate or acetate. We have shown that, regardless of the strain, the degree of changes in respiration, membrane potential, NAD/NADH ratio, ATP and glutathione (GSH) strongly depends on the initial growth rate and the degree of its inhibition. The deletion of the regulator of the general stress response RpoS, although it influenced the expression of antioxidant genes, did not significantly affect the tolerance to ciprofloxacin at all growth rates. The mutant lacking TolC, which is a component of many E. coli efflux pumps, showed the same sensitivity to ciprofloxacin as the parent. The absence of porin OmpF slowed down the entry of ciprofloxacin into cells, prolonged growth and shifted the optimal bactericidal concentration towards higher values. Deficiency of RecA, a regulator of the SOS response, dramatically altered the late phase of the SOS response (SOS-dependent cell death), preventing respiratory inhibition and a drop in membrane potential. The recA mutation inverted GSH fluxes across the membrane and abolished ciprofloxacin-induced H2S production. At all growth rates, this mutation reduced logCFU ml-1 by about 3 orders of magnitude. All studied mutants showed an inverse linear relationship between logCFU ml-1 and the specific growth rate, that is, the activity of antibiotic targets. Mutations shifted the plot of this dependence relative to the parental strain according to their significance for ciprofloxacin tolerance.
Influence of Local Mineral Raw Materials On The Commercial Success of Aveiro Production of Ancient Ceramic Sugar Jars
Authors: Fernando Rocha , Morgado Paulo 
Published: July 2021

Abstract
Sugar forms were conic ceramic jars having a hole at the bottom, being used specifically for the stage of the purge of the sugar cake. These pieces played a paramount role in sugar production cycle, being used for the maturation of the sugar, and since the 15th until the beginning of the 19th centuries, the old pottery centres from Aveiro and Lisbon regions, produced heavily these “formas de açúcar” (“sugar jars”) which were exported to sugar production areas, at places as diverse as Madeira, Canaries, Cape Verde, Cuba and Brazil. Mineralogical analysis by x-ray powder diffraction was carried out on bulk samples. Chemical composition was assessed by X-Ray fluorescence. The obtained results gave important information about the composition of the studied materials, and also about their raw materials. Mineralogical and chemical data obtained in samples from Aveiro point to a local production, using the upper Cretaceous (Maastrichian) marly (dolomitic) clays and clayey sands as main raw materials. Ceramics from Barreiro (Lisbon) are in general more silicated and less carbonated, composition close to the Tagus Cenozoic Basin clays. The higher iron content of Aveiro clays favours the glazing of ceramic paste at lower temperatures, giving better mechanical resistance which can justify "their best quality", as referred to in ancient documents.
Terminal Differentiation of Keratinocytes Was Damaged In Type 2 Diabetic Mice
Authors: Takayanagi Takeshi , Hirai Hiroyuki , Asada Yohei , Yamada Takaaki , Hasegawa Seiji , Tomatsu Eisuke , Maeda Yoshiteru , Yoshino Yasumasa , Hiratsuka Izumi , Sekiguchi-Ueda Sahoko , Shibata Megumi , Seino Yusuke , Sugimura Yoshihisa , Akamatsu Hirohiko , Itoh Mitsuyasu , Suzuki Atsushi 
Published: July 2021

Abstract
Aims: Although skin manifestations are common in diabetic patients, its characteristics are poorly identified. This study explored the differentiation process of keratinocytes in type 2 diabetes mellitus (T2DM) in vivo.Methods: Back skin of T2DM model KKAy/TaJcl mice (KKAy) and C57BL/6JJcl mice (control) aged 8 and 12 weeks was used. The mRNA expression of differentiation markers of keratinocytes was measured by quantitative real-time polymerase chain reaction (qRT-PCR). The expression of each marker in situ was examined immunohistochemically.Results: KKAy mice showed hyperglycemia versus control mice. The histological findings showed increased thickness and structural impairment of epidermal tissue in KKAy mice. The qRT-PCR revealed that the expression of integrin beta 1 and keratin 14 in KKAy and control mice was identical. However, the expression of involucrin at 8 w, keratin 10 at 12 w, and filaggrin and loricrin at 8 and 12 w was decreased in KKAy mice. Immunohistochemical findings showed that filaggrin was markedly decreased in KKAy mice, though Ki-67 remained unchanged in control mice. Conclusion: The terminal differentiation process was impaired in the diabetic skin, while keratinocyte proliferation was preserved. Damaged terminal differentiation of keratinocytes may contribute to impairment of the skin barrier function in diabetic dermatoses.
The Impact of Surgeon Referral and a Radiation Oncologist Productivity-Based Metric on Radiotherapy Receipt Among Elderly Women with Early-Stage Breast Cancer: Analysis from a Tertiary Cancer Network
Authors: Patel Mira A , Cha Elaine E. , Lobaugh Stephanie , Zhang Zhigang , McCormick Beryl , Braunstein Lior Z. , Cahlon Oren , Powell Simon N. , Morrow Monica , Khan Atif , Gillespie Erin F. 
Published: July 2021

Abstract
Purpose: Guidelines for early-stage breast cancer allow for radiotherapy (RT) omission following breast conserving surgery (BCS) among older women, though high utilization of RT persists. This study explores surgeon referral and the effect of a productivity-based bonus metric for radiation oncologists in an academic institution with centralized quality assurance (QA) review.Methods: We evaluated patients >70 years of age treated with BCS for ER+ pT1N0 breast cancer at a single tertiary cancer network between 2015-2018. The primary outcomes were radiation oncology referral and RT receipt. Covariables included patient and physician characteristics, and treatment decisions before versus after productivity metric implementation. Univariable generalized linear effects models explored associations between these outcomes and covariables. Results: Of 703 patients included, 483 (69%) were referred to radiation oncology and 273 (39%) received RT (among those referred, 57% received RT). No difference in RT receipt pre- versus post- productivity metric implementation was observed (p=0.57). RT receipt was associated with younger patient age (70-74 years, OR 2.66, 95% CI 1.54-4.57) and higher grade (grade 3, OR 7.75, 95% CI 3.33-18.07). Initial referral was associated with younger age (70-74, OR 5.64, 95% CI 3.37-0.45) and higher performance status (KPS ³90, OR 5.34, 95% CI 2.63-10.83). Conclusion: Non-referral to radiation oncology accounted for half of RT omission, but was based on age and KPS, in accordance with guidelines. Lack of radiation oncologist practice change in response to misaligned financial incentives is reassuring, potentially reflecting centralized QA review. Multi-institutional studies are needed to confirm these findings.
Universe: the dynamics of the minimum and maximum expansion states
Authors: Petrakis Sócrates 
Published: July 2021

Abstract
Two hypotheses stand out in describing the evolution of the Universe. The predominant one predicts that the current expansion began at a certain instant and will not preserve any variation of energy that performs work; apparent flat Universe (Ω = 1) is advocated by relativistic calculations and observational data, with an end or thermal death at its maximum expansion (3D space). The other hypothesis considers that the Universe is always cyclical (alternating phases of expansion and contraction). This proposal aims to demonstrate that both hypotheses can be correct by not being distinct, but complementary. Supported by the immutability of physical laws, analyses of concepts such as space, mass, energy, gravity, spin, and entropy define an exclusive presence of 1D space in the minimum and maximum expansion states of the Universe. With our 3D space Universe created and existing between these extreme states, a complete universal evolution is outlined. More objectively, all the exposed dynamics complements the usual relativity. The concept of complete rest energy (1D space) was able to be applied, demonstrating that the evolution of the entire Universe is spatially dynamic in a perpetual time dimension, always recreating our Universe.
Deep Neural Network for the Determination of Transformed foci in Bhas 42 Cell Transformation Assay
Authors: Masumoto Minami , Fukuda Ittetsu , Furihata Suguru , Arai Takahiro , Kageyama Tatsuto , Ohmori Kiyomi , Sirakawa Shinichi , Fukuda Junji 
Published: July 2021

Abstract
Bhas 42 cell transformation assay (CTA) has been used to estimate the carcinogenic potential of chemicals by exposing Bhas 42 cells to carcinogenic stimuli to form colonies, referred to as transformed foci, on the confluent monolayer. Transformed foci are classified and quantified by trained experts using morphological criteria. Although the assay has been certified by international validation studies and issued as a guidance document by OECD, this classification procedure is laborious, time consuming, and subjective. We propose using deep neural network to classify foci more rapidly and objectively. To obtain datasets, Bhas 42 CTA was conducted with a potent tumor promotor, 12-O-tetradecanoylphorbol-13-acetate, and focus images were classified by experts (1405 images in total). The labeled focus images were augmented with random image processing and used to train a convolutional neural network (CNN). The trained CNN exhibited an area under the curve score of 0.95 on a test dataset significantly outperforming human-based classifiers by beginners of focus judgment. The generalization performance of unknown chemicals was assessed by applying CNN to other tumor promotors exhibiting an area under the curve score of 0.87. The CNN-based approach could support the assay for carcinogenicity as a fundamental tool in focus scoring.