bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimal Mineral – Deckensysteme neu gedacht: Die Zukunft des Bauens nachhaltig gestalten
Authors: Aziz Saqib , Alexander Bradley , Gengnagel Christoph , Loutfi Jamila 
Published: December 2024

AbstractDeckensysteme sind aufgrund ihres Volumens und ihrer Materialität – neben der Gründung – zentrale Schlüsselkomponenten für nachhaltiges Bauen. Innovationen in diesem Bereich können den Ressourcenverbrauch und die Treibhausgasemissionen erheblich reduzieren, während gleichzeitig die regionale Vielfalt im Bauwesen gestärkt wird. Der vorgestellte Forschungsansatz zielt nicht nur auf Materialeinsparungen ab, sondern strebt mithilfe digitaler Technologien eine umfassende Optimierung an. Dabei dienen historische Bausysteme mit bewährten zirkulären Eigenschaften als Grundlage für die Entwicklung. Im Rahmen des Projekts Minimal Mineral werden digitale Fertigungsmethoden erforscht, um einen Katalog innovativer, multimodaler Deckensysteme zu entwickeln. Die konsequente Anwendung computergestützter Entwurfs‐ und Analysewerkzeuge sowie digitaler Fertigungsverfahren wie 3D‐Druck und Robotik ermöglichen neue ressourcenschonende Bauweisen und den Einsatz nachhaltigerer Materialien. Der resultierende Bauteilkatalog basiert auf erprobten historischen Bauweisen und sichert so eine schnelle mögliche praktische Anwendung. Der Fokus des Berichts liegt auf Voruntersuchungen für eine prototypische Anwendung für ein aktuelles Bauvorhaben in Nordfrankreich, das sich derzeit in der Planungsphase befindet. Das geplante neuartige Deckensystem besteht aus vorgefertigten mineralischen Schalungskörpern mit integrierten Schallabsorptionsfunktionen.
Optical, Opto‐Mechanical, and Antimicrobial Characterization of TiO2 and ZnO‐Enhanced Polypropylene Fibers Using Interferometric Techniques and Fourier Transform Analysis
Authors: Aldosari F. M. , Sefrji Fatmah O. , Alsharari Abdulrhman M. , Al‐Ghamdi S. A. , Alqarni Sara A. , Hadi Muhammad , Alamoudi Wael M. , El‐Metwaly Nashwa M. 
Published: December 2024

ABSTRACTThis study investigates the optical, mechanical, and antimicrobial properties of polypropylene (PP) fibers enhanced with titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles. Using a Mach–Zehnder interferometric system, we examined the refractive indices, birefringence, and opto‐mechanical behavior of blank PP, PP/TiO2, and PP/ZnO nanocomposite fibers under various conditions, including different polarization orientations and during cold drawing processes. The 2D Fourier transform algorithm is employed to analyze interferometric data, enabling precise measurements of refractive index profiles and birefringence. Results show that both TiO2 and ZnO nanoparticles significantly enhance the optical and mechanical properties of PP fibers. PP/TiO2 fibers exhibited the highest refractive index (1.530) and birefringence (0.0459), followed by PP/ZnO (1.522 and 0.040) and blank PP (1.520 and 0.031). The maximum draw ratios achieved were 4.2, 3.9, and 3.5 for PP/TiO2, PP/ZnO, and blank PP fibers, respectively, indicating improved mechanical properties in the nanocomposites. Antimicrobial efficacy was evaluated using the shaking flask method and optical density measurements against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. PP/ZnO fibers demonstrated the highest antimicrobial activity, with growth reductions ranging from 64.8% to 80.4%, followed by PP/TiO2 fibers (56.0% to 70.3%).
Impact of Hormone on Growth and GA3 Regulation of Anthocyanin Biosynthesis in Suspension‐Culture Cells of Cyclocarya paliurus
Authors: Pan Chuanqing , Liu Yuan , Tang Daobang , Chen Jiguang , Yin Zhongping 
Published: December 2024

ABSTRACTHormones are effective in regulating plant metabolism and, therefore, are often used in plant cell culture to increase the yield of target products. This study investigated the effects of hormones on the growth and anthocyanin biosynthesis of suspension‐cultured red Cyclocarya paliurus cells. Additionally, the mechanism by which gibberellin induces anthocyanin biosynthesis was explored through multi‐omics integrated analysis and the assay of the dynamic changes in signaling molecule concentration. The results showed that the total anthocyanin content and yield of suspension‐cultured cells, when induced by 1.0 mg L⁻¹ Gibberellin A3 (GA3), experienced increases of 1.92‐ and 1.83‐fold, respectively. The application of exogenous GA3 activated the synthesis and transduction of four signaling molecules, that is, nitric oxide (NO), hydrogen peroxide (H2O2), salicylic acid (SA), and jasmonic acid (JA), in the cells and altered the expression patterns of transcription factors. The altered expression of transcription factors upregulated the expression of anthocyanin biosynthetic genes such as anthocyanin‐3‐O‐glucosyl transferase and leucoanthocyanidin dioxygenase, while downregulated the expression of anthocyanin reductase and flavonoid 3′,5′,‐hydroxylase, which activated the anthocyanin biosynthesis pathway, ultimately leading to a significant increase in anthocyanin biosynthesis. This research work establishes a foundation for further research on the role of hormones in regulating anthocyanin biosynthesis in suspension‐cultured plant cells.
Inhibitory Effect of PRMT5/MTA Inhibitor on MTAP‐Deficient Glioma May Be Influenced by Surrounding Normal Cells
Authors: Wang Yunjie , Sun Xiaohui , Ma Runchen , Zhang Xiaofan , Ji Shengmin , Liu Zhaofeng , Yang Gangqiang , Wang Hongbo , Zhang Peng , Zhang Jianzhao , Tian Jingwei 
Published: December 2024

ABSTRACTBackgroundMethylthioadenosine phosphorylase (MTAP) and protein arginine methyltransferase 5 (PRMT5) are considered to be a synthetic lethal pair of targets, due to the fact that deletion of MTAP leads to massive production of methylthioadenosine (MTA) decreasing the activity of PRMT5. In vitro and in vivo experiments have demonstrated that MRTX1719, a small molecule that selectively binds PRMT5/MTA complex, significantly inhibits the proliferation of MTAP‐deficient tumors and has a weak toxic effect on normal cells. However, it has been reported that MTAP‐deleted tumors did not significantly accumulate MTA in vivo due to metabolism of MTA by MTAP‐expressing stroma, which might lead to a diminished anti‐cancer effect of MRTX1719.MethodsWe first analyzed whether there were MTAP‐expressing normal intracerebral cells around MTAP‐deficient glioma tissues by paraffin‐embedded tissue microarray of human glioma specimens. Then, in vivo and in vitro models of MTAP‐deficient gliomas coexisting with neurons or glial cells were constructed for evaluating the effectiveness of the anti‐tumor effects of MRTX1719 in this setting.ResultsMTAP‐deficient gliomas were surrounded by a large number of MTAP‐expressing normal cells, and the presence of these cells significantly reduced the inhibitory effect of MRTX1719 on MTAP‐deficient glioma cells in vitro and in vivo.ConclusionsDue to the complexity of the tumor environment in vivo, the anti‐tumor effects of PRMT5/MTA‐specific inhibitors may be somewhat attenuated, and their ability to achieve suitable therapeutic effects in the clinic might require more in‐depth studies.
Beyond BRAFV600E: Investigating the Clinical and Genetic Spectrum of Langerhans Cell Histiocytosis in Children
Authors: Tang Xue , Gao Ju , Guo Xia , Wan Zhi , Sun Jing‐jing 
Published: December 2024

ABSTRACTBackgroundLangerhans cell histiocytosis (LCH) is the most prevalent histiocytic disorder in pediatric populations, with a highly heterogeneous clinical presentation. Currently, the correlation between clinical phenotypes and molecular alterations in childhood LCH, besides the BRAFV600E mutation, has not been sufficiently studied.MethodsThis study presented data on 33 pediatric LCH patients treated at our center who exhibited various molecular alterations other than the BRAFV600E mutation. Additionally, we comprehensively reviewed pediatric LCH cases with non‐BRAFV600E molecular alterations reported from January 2010 to August 2024.ResultsA total of 309 pediatric LCH patients with molecular alterations beyond BRAFV600E were enrolled in the study, among whom 33 were from our center. In these LCH cases, 49 kinds of MAP2K1 mutations, 31 kinds of BRAF mutations, and 4 kinds of ARAF mutations were found. At our center, two patients with multisystem LCH with risk organ involvement, both with BRAFN486_P490del mutation, showed poor response to induction chemotherapy for 6 weeks. Among the 303 LCH patients with MAP2K1 or other BRAF alterations, patients with the MAP2K1 mutation had a higher prevalence of single‐system bone involvement (SS‐bone) than patients carrying the BRAF mutation (p = 0.0072). Within the MAP2K1 group, exon 3 mutations exhibited a stronger association with SS‐bone than exon 2 mutations (p = 0.042). Additionally, patients with the BRAF exon 15 mutation and MAP2K1 exon 2 mutation had higher rates of LCH onset before age 3 compared with patients carrying the BRAF exon 12 mutation and MAP2K1 exon 3 mutation (p = 0.037; p = 0.0015). Patients carrying the BRAF mutation in exon 15 had higher rates of liver involvement compared with patients carrying the exon 12 (p = 0.042).ConclusionsPediatric LCH patients often carry recurrent somatic MAP2K1 and BRAF mutations, which are associated with clinical manifestations.
Peer Victimization Among a Clinical Sample of Turkish Youth With Autism Spectrum Disorder
Authors: Gündüz Yagmur , Alnak Alper , Coskun Murat 
Published: December 2024

ABSTRACTYoung subjects with developmental disabilities are vulnerable and may experience frequent peer victimization. Quantifying the risk and associated factors and consequences of peer victimization among this vulnerable population would have clinical and public health implications. In this descriptive cross‐sectional study, we aimed to investigate peer victimization and relationships with psychiatric comorbidity and sociodemographic/socioeconomic variables in a clinical sample of young subjects with ASD without ID in a nonwestern country. The Revised Olweus Bully/Victim Questionnaire and a semistructured diagnostic instrument were used to investigate victimization experiences and psychiatric disorders, respectively. The majority of the subjects (68.8%) experienced victimization (verbal, relational or physical) by their peers. Only 45% (18/40) of the victims' parents were aware of their child's victimization status. Frequency of generalized anxiety disorder and self‐reported anxiety scores were higher in those with more severe victimization. A binary logistic regression analysis for victimization yielded significant associations for having a single parent, a higher maternal educational level, a lower paternal educational level and higher depression scores. Psychiatric evaluation of young subjects with ASD should include questioning about bullying experiences. Because parents may not be aware of bullying experience, disclosing bullying experience only depending on the parental report may cause an underreport of bullying among young subjects with ASD.
Indole Derivatives as Promising Anti‐Dengue Agents: A Review of Recent Advances
Authors: Januário Marcelo Augusto Pereira , Junior Celso de Oliveira Rezende , Castro‐Gamboa Ian 
Published: December 2024

ABSTRACTDengue, a mosquito‐borne disease transmitted by Aedes mosquitoes, is a significant global health concern. Despite extensive research, effective treatments remain limited. The indole nucleus, known for its diverse pharmacological properties, has emerged as a promising scaffold for anti‐dengue drug discovery. This review comprehensively examines recent advancements in the fields of natural products, medicinal chemistry, and computer‐aided drug design focused on discovering indole‐based anti‐dengue agents. We discuss the rationale for targeting indole frameworks, highlight key structural features associated with anti‐dengue activity, and summarize recent research findings. The review aims to provide valuable insights for researchers working on developing novel anti‐dengue therapeutics.
Entrapment of Lipase from Candida antarctica in a Xerogel for the Production of Biodiesel from Waste Cooking Oil
Authors: Decarpigny Cédric , Bigan Muriel , Froidevaux Rénato 
Published: December 2024

AbstractThe process to synthesize biodiesel is well‐developed and optimized to overcome the disadvantages like the competition with agriculture using feedstock, and the problematics in the process. Oils from waste and enzymatic catalysis have proven to be good solutions to these problems. Lipases are currently the most commonly used enzymes in the transesterification of oils; nevertheless, enzymes have a high cost and must be immobilized to offer repetitive reuse. This work focuses on the synthesis and the optimization of the conditions of a xerogel where the lipase from Candida antarctica is immobilized by entrapment. The xerogel synthesized here, a glass‐like material, proved to be very effective in maintaining the enzyme on its structure, with an immobilization yield of 96 % and an activity of 5.3 U/mg (free lipase=12.1 U/mg). By grinding this xerogel, the immobilization yield remained constant (94 %). Nevertheless, grinding the xerogel allowed better diffusion of reagents, and the activity reached 9.7 U/mg. Using this xerogel in biodiesel production had a positive effect on CALB efficiency by increasing the biodiesel yield, 46.1 % against 15.1 % with free CALB. Finally, the catalyst could be reused for five runs without loss of activity.
Recent Advance in Sensitive Detection of Demethylase FTO
Authors: Shang Min , Qin Jingying , Zhao Bingyue , Luo Qian , Wang Huimin , Yang Changying , Liu Hanghang , Ran Jiabing , Yang Wei 
Published: December 2024

AbstractMethylation modification is a critical regulatory mechanism in epigenetics and plays a significant role in various biological processes. N6‐methyladenosine (m6A) is the most common modification found in RNA. The fat mass and obesity‐associated protein (FTO) facilitate the demethylation of m6A in RNA, and its abnormal expression is closely linked to the development of several diseases. As a result, FTO has the potential to serve as an important biomarker for clinical disease diagnosis. Despite its significance, there has been a lack of comprehensive reviews addressing advancements in detection methods for the demethylase FTO. This review provides an overview of the progress in FTO detection methods, ranging from traditional approaches to innovative techniques, with a particular emphasis on recently reported advancements. These novel detection methods can be categorized into strategies based on enzymes, functional nucleic acids (FNA), and conformational changes. We summarize the principles and applications of these detection methods and discuss the current challenges and prospects in this field.
Mechanochemical Ball Milling Approach to C(sp3)‐H Functionalization of 8‐Methylquinolines
Authors: Narayanan Nanditha Kattukudiyil , Schnürch Michael 
Published: December 2024

AbstractA mechanochemical, highly regioselective rhodium(III)‐catalyzed C─H methylation of 8‐methylquinolines is reported. The methylation method reported in this study, is often solvent‐free or uses minimal solvent (liquid assisted grinding), operates without external heating under mild reaction conditions, demonstrating tolerance for various functional groups. Moreover, the reaction time is significantly reduced compared to the solvent‐based variant. Notably, the reaction can be carried out using a pestle and mortar instead of ball milling as well, highlighting the operational simplicity of this approach for achieving challenging C(sp3)‐H activation under more sustainable conditions.
Recent Advances in Electrochemical CO2 Reduction Catalyzed by Single‐Atom Alloys
Authors: Wu Wenjie , Long Jun , Xiao Jianping 
Published: December 2024

AbstractWith the extensive use of fossil fuels and CO2 emission, the development of effective electrocatalysts to convert CO2 into high‐value‐added chemical products has become an important issue in academia community. Single‐atom alloys (SAA) integrate the advantages of single‐atoms catalysts and alloys, which can improve the activity and selectivity of CO2 electroreduction (CO2RR) by adjusting the electronic and geometric structure of the host and guest metals simultaneously. This article provides a comprehensive review on the research advances of SAA catalysts used for CO2RR, including the synthesis and characterizations, computational design, experimental performances, and electronic structure effects of different SAA. Specifically, the correlations between experimental results and theoretical studies have been highlighted and discussed clearly in this review, which provide unique fundamental insights on the CO2RR performances of SAA catalysts. Based on these understanding, we finally propose a workflow combining both computational and experimental methods to rationally design the SAA, which can help the further development of CO2RR catalysts in the future.
A Dual‐Functional Sulfur‐Rich Copolymers for Stable Anchoring and Enhanced Conversion of Polysulfide in Lithium‐Sulfur Batteries
Authors: Fu Yao , Jin Yang , Guo Fang‐Fei , Cao Fei , He Bin 
Published: December 2024

AbstractSulfur‐rich copolymers have gained a great deal of attention as promising cathode materials in Li−S batteries due to their low cost and naturally uniform sulfur dispersion. However, the poor electrical conductivity and shuttle effect cause rapid capacity decay and low sulfur utilization especially under high sulfur loading and low electrolyte/sulfur ratio. Herein, the Fe1‐xS/C dispersed and Se‐containing sulfur‐rich copolymer (FSP) was synthesized by one‐pot reaction of ferrocene, trithiocyanuric acid with SexSy. In such process, the trithiocyanuric acid reacts with SexSy to form Se‐containing sulfur‐rich copolymers. Simultaneously, ferrocene reacts with sulfur to form highly dispersed Fe1‐xS/C within sulfur‐rich copolymers. The covalent chemical binding of sulfur in the FSP effectively suppress the shuttle effect of polysulfides by chemical binding. Meanwhile, the Se improves the conductivity of FSP, which enhances the reaction kinetics. Moreover, the highly dispersed Fe1‐xS/C in the FSP is able to effectively catalyze polysulfide conversion and inhibit the shuttle effect. As a result, the optimized FSP electrode exhibits a high capacity of 1330 mAh g−1 at 0.2 C. Even under high sulfur loading (4.08 mg cm−2) and low E/S ratio (6 μL mg−1), the FSP cathode demonstrates a remarkable capacity of 734.7 mAh g−1 at 0.2 C.
Reversible Metal‐Mediated Molecular Switching of a Phosphaethene Polyaromatic Hydrocarbon
Authors: Bhowmick Toma , Wells Jordann A. L. , Asif Ansari Mohd , Steen Jorn D. , Crespi Stefano , Orthaber Andreas 
Published: December 2024

AbstractThis experimental and theoretical study illustrates how phosphaalkenes, which are isolobal to alkenes, can utilize a variety of external triggers for molecular switching. The E/Z isomerization of a truxene‐based phosphaalkene, i. e. TruxC=P‐Mes* (Mes*=2,4,6‐tris‐t‐butyl‐benzene), is accomplished by irradiation, metal coordination, or deprotonation of the truxene core. The reversible and quantitative Z/E double bond isomerization by gold(I) coordination/decoordination of the phosphorous lone pair represents a novel fuelling strategy for molecular switches.
Exploring the Catalytic Potential of Bioinspired Taurine‐Functionalized Carbon Quantum Dots as Bifunctional Catalysts for Diverse Sustainable Organic Transformations in Water
Authors: Jyoti Nirmal , Raigar Ashok K. , Saini Kamlesh , Manju  , Guleria Anjali 
Published: December 2024

AbstractTaurine‐functionalized Carbon Quantum Dots (Tau‐CQDs) were synthesized and evaluated for their catalytic potential under metal‐, acid‐, and base‐free sustainable conditions, using water as a solvent for various organic transformations, including Knoevenagel condensation, the Biginelli reaction, and the Knoevenagel–Michael cascade. These bioinspired N, S‐doped CQDs exhibit bifunctionality, acting as hydrogen bond donors and acceptors for C−C, C−N, and C−O bond formation. Comprehensive characterization of the catalyst was performed using HRTEM, PXRD, XPS, FTIR, AFM, Zeta potential, UV–Vis, and photoluminescence spectrometry. The Tau‐CQDs demonstrated excellent reusability, maintaining catalytic performance over 10 cycles. Green chemistry metrics, including a low E‐factor, high atom economy, and favorable PMI, CE, and RME values, highlight this approach's environmental and economic advantages. Key properties, such as high reaction yields, short reaction times, water solubility, enhanced surface functionality, non‐toxicity, and mild operating conditions, underscore the broader significance of Tau‐CQDs as an efficient, sustainable catalytic platform. Additionally, the simple recovery of the catalyst via filtration, without the need for further purification, enhances its practical applicability.
Unusual Reaction of Isocyanides with Aromatic Aldehydes Catalyzed by a Supramolecular Capsule
Authors: Fiorini Luca , Köster Jesper , Piccini GiovanniMaria , Goldfuss Bernd , Prescimone Alessandro , Fabris Fabrizio , Tiefenbacher Konrad , Scarso Alessandro 
Published: December 2024

AbstractThe supramolecular resorcinarene hexameric capsule efficiently promotes the unprecedented reaction between isocyanides and electron‐deficient aromatic aldehydes leading to the formation of imines and carbon monoxide. The mechanism of the reaction was investigated via isotope labelling, kinetic analysis of the reaction, computational studies and the independent synthesis of a proposed intermediate. Control experiments indicate that the formation of the key aziridinone intermediate is limited to the cavity of the capsule.
Photoinduced Deprotection of 2‐Nitrophenylneopentyl Glycol Boronates Enables Light‐Triggered Polycondensation of Siloxanes
Authors: Boyet Marion , Colin Boris , Michaud Guillaume , Genin Emilie , Pinet Sandra , Chabaud Laurent , Pucheault Mathieu 
Published: December 2024

AbstractVarious protecting groups have been developed for boronic acids, mostly based on diols. Alternatives include trifluoroborates and amine complexes, which offer easier synthesis and release under milder conditions. We present here a new strategy involving photocleavable protecting groups for boronic and borinic acids, based on the 2‐nitrobenzyl motif. A screening of several 1,2‐ and 1,3‐diols bearing a 2‐nitrobenzyl group led us to identify 1‐(2‐nitrophenyl)neopentyl glycol (npnp) for the protection of boronic acid derivatives. This diol is easily prepared in a single step on gram scale, and the corresponding npnp boronates are stable in wet acetonitrile at 90 °C for several days, and under under acidic conditions. Irradiation at 365 nm in acetonitrile allows for the controlled liberation of boronic acids in good to excellent yields, a method also applied to a dimesitylborinic ester bearing a 2‐nitrobenzylalcohol moiety. 1‐(2‐Nitrophenyl)neopentyl glycol boronates ArB(npnp) demonstrated their utility in light‐triggered siloxane crosslinking. We showed that catalysts incorporated into a polymer matrix, irradiated, and then incubated at 50 °C for 7 days resulted in efficient polymerization, forming solid materials in some cases.