bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proses Pembuatan Komposit Matriks Logam Al5Cu4Mg/Al2O3(p) dengan Metode Pengadukan dan Tempa
Authors: Romijarso Toni Bambang , Subagja Rudi , Priadi Dedi 
Published: September 2021

AbstrakKomposit Matriks Logam (KML) merupakan salah satu material yang banyak digunakan di industri manufaktur terutama yang berbasis alumunium, karena logam ini mempunyai berat jenis yang rendah. Pada saat ini pembuatan KML bermatriks alumunium dengan penguat Al2O3 sudah banyak dibuat dan digunakan di industri. Proses pembuatan KML di Indonesia merupakan hal yang baru-baru ini ramai diminati, meskipun penelitian awal sudah dilakukan jauh sebelumnya. Faktor penting pada pembuatan KML adalah menghidari adanya keropos atau adanya porositas pada hasil produk. Oleh karena itu, pada percobaan ini setelah dilakukan proses pengadukan dilanjutkan dengan proses tempa untuk mengurangi adanya porositas tersebut. Bahan yang digunakan sebagai matriks adalah Al-5%Cu-4%Mg dimana Mg sebagai wetting agent, sedangkan penguat yang digunakan adalah 5 dan 10% Vf Al2O3. Pengujian mekanik yang dilakukan antara lain uji tarik, kekerasan dan keausan, sedangkan pengujian fisik, yaitu: metalografi, berat jenis, porositas, SEM/EDS dan XRD, untuk melihat fasa dan senyawa baru. Hasil pengujian menunjukkan dengan adanya penguat Al2O3 terjadi kenaikkan sifat mekanik antara lain dengan naiknya angka kekerasan dan naiknya nilai ketahanan aus. AbstractThe Metal Matrix Composite (MMCs) is one of the widely used materials in the manufacturing industry, especially those based on aluminum, because this metal has low specific gravity. At this time, aluminum matrix KML with Al2O3 reinforcement has been widely made and used in industry. The process of making MMCs in Indonesia have just developed recently, even tough the previous research have been conducted for a long time. The important factor in making MMCs in to prevent the porosity at it’s product. This is the reason why we conduct a forging process after the agitation process. The materials used as matrix is Al-5%Cu-4%Mg where Mg is the wetting agent, while the reinforcement used is 5 and 10% Vf Al2O3. Mechanical tests include: tensile, hardness and wear tests, while physical tests: metallography, specific gravity, porosity, SEM/EDS and XRD, to see new phases and compounds. With the addition of Al2O3 reinforcement there is an increase in mechanical properties, among others, by increasing the number of hardness and increasing wear resistance.
Evaluation of Anti-Retroviral Drugs Effects on Liver Function Tests of HIV Infected Individuals
Authors: Olayonwa Damilare , Oyedeji Samuel 
Published: September 2021

The Human Immunodeficiency Virus (HIV) continues to be a major global public health issue, having claimed more than 35 million lives so far. Antiretroviral therapy, the drug used to treat HIV patients, had been reported to have an adverse effect on patients’ livers. Therefore, this research aims to assess the parameters for measuring liver injury of HIV patients undergoing antiretroviral therapy in Owo and to determine the patients' vulnerability to liver injury. The study sample was divided into five groups comprising Control groups and groups with 6 months, 1 year, 3 years and 5 years’ periods of administration of an antiretroviral drug. Serum was separated from their blood and values of ALT, ALP and BILT were determined. The results of profiling the patients based on values ALT, ALP and BILT indicated that 73%, 71% and 59% of the patients are within the reference range of the parameters, respectively. Further analysis of the percentage of patients likely to have liver diseases indicated that only 3.2% are prone to liver injury. The results of the One-way Analysis of Variance of the mean values of the groups on ALT, ALP and BILT indicated differences in mean values of the groups. It is suggested that a longitudinal study should be carried out to determine the effect of seasonal variation in the value of the studied parameters. It is also suggested that a wider interval of the period for the groups should be used in the future to determine whether there will be a relationship between the period of administration of the drug and the parameters.
“Not Writing New Rules, Merely Rat-ifying”: Musical Theatre Goes Digital in Ratatouille: The Musical
Authors: Lusie Cuskey  
Published: September 2021

On TikTok, #RatatouilleTheMusical was the pandemic daydream and collaborative creation of dozens of amateur and out-of-work theatre artists. The January 1 benefit performance of Ratatouille: The Musical ratified the work of its creators by bringing it to a broader audience, but did not always honor its tone and intent. Regardless of the product itself, however, Ratatouille: The Musical offers hope for the resilience and adaptibility of the rising generation of musical theatremakers.
Fatigue and conformist traits in the performance of young swimmers
Authors: Núñez-Espinosa Cristian , Herrera-Valenzuela Tomas , Valdés-Badilla Pablo , Estrada-Goic Claudia 
Published: September 2021

Objective: This study determines the relationship between the fatigue of adolescent swimmers in high-level competitions during two continuous periods of maximum performance and the degree that swimmers conform to norms during these periods.
Methods: We evaluated the conformist trait and three areas of fatigue in two consecutive competitive periods, in 25 young elite swimmers. The measures were evaluated before (_B) and after (_A) of pre (t1; t3) and pos (t2; t4) competition in each period. Millon Adolescent Clinical Inventory was applied for identifies the more adherens (AD; n=12) or detached from the norm (DN; n=13) conformist traits. Wingate test, Heart rate variability (RMSSD; SDNN), WISC-V, and Stroop test were evaluated.
Results: DN group present lower fatigue in t1 but an increase in t2, t3, and t4. AN present higher RMSSD_B and SDNN_B in t1. In t3, the mental fatigue of DN was correlated negatively with RMSSD_B; SDNN_B. Both groups had more SDNN_B than SDNN_A in t4.
Conclusions: Physical fatigue was important conditioning in both groups, however, the DN group may be more sensitive to physiological and mental fatigue directly affecting the performance.
Brentuximab vedotin in adult patients with HL CD30+ at high risk of relapse or progression following ASCT: a cost-analysis in Italy
Authors: Breschi Gian Luca , Demma Federica , Morelli Paolo , De Francesco Maria 
Published: September 2021

Abstract
Introduction: In Hodgkin Lymphoma (HL), the early administration of brentuximab vedotin (BV) represents a highly effective treatment to consolidate patients after autologous stem cell transplantation (ASCT). For this indication, the Summary of Product Characteristics (SPC) reports a lower medical resource utilization in BV vs. placebo. This study aimed at assessing costs accrued by using BV in consolidation after ASCT and compare them with the resource consumption associated with the main options today used in Italy for HL.
Methods and results: A cost-analysis based on patients at high risk of relapse (HL CD30+-HR) after ASCT was developed by collecting data about health care consumption (drugs and monitoring). The model is described by two arms, "A," where BV is used as consolidation therapy after ASCT, and "B", where patients are treated only at the time of relapse. A 3-year time horizon and the Italian National Health System perspective were adopted. All data inputs for the analysis were sourced from the available literature and official list prices. The simulation was integrated by sensitivity analysis. The introduction of BV as consolidation therapy would allow savings in terms of drug acquisition and resource consumption. Over a 3-year time frame, the Consolidation arm’s overall expenditure was 137,059€ vs. 225,418€ in the Non-consolidation arm. Early after the ASCT, BV administration guarantees a long period free from relapses (5-year PFS is not reached), thus reducing the clinical and economic burden of the subsequent therapies needed to treat further relapses.
Conclusions: The present pharmacoeconomic analysis shows that the introduction of BV as consolidation therapy after ASCT represents a sustainable expenditure for the National Healthcare System (NHS) and a cost-saving paradigm when compared with the drug mainly used for treating the relapses.
Optimización de plataforma con movimiento rotacional horizontal controlable para un sistema de medición de funciones de transferencia de cabeza
Authors: Mendez Martín , Tommasini Fabián C. , Ferreyra Sebastián P. , Guido R. Martín , Bordón Juan Cruz , Scaliti Fermín 
Published: September 2021

Para simular computacionalmente fuentes sonoras distribuidas espacialmente y lograr sonido tridimensional, se utilizan las funciones de transferencia de cabeza (HRTFs) como filtros. Para completar una esfera densa de puntos con estas funciones alrededor de un sujeto, es necesario posicionar una fuente sonora en diferentes ángulos y capturar las respuestas impulsivas mediante micrófonos ubicados en las orejas. Actualmente, estamos desarrollando un sistema de medición de HRTFs que cuenta con un arco soporte semicircular vertical para altavoces y una plataforma rotativa horizontal controlable donde se ubica el sujeto. Contamos con una plataforma diseñada originalmente para otro propósito y que soporta hasta 400 N de peso. En este trabajo se propone rediseñarla y optimizarla para permitir el movimiento de una persona sentada, tolerando hasta ~2200 N. En base a ensayos realizados sobre la plataforma actual, se detectaron situaciones físicas no deseadas y se propusieron soluciones validadas mediante modelos teóricos y simulaciones numéricas del comportamiento estático.
HCG18 Participates in Vascular Invasion of Hepatocellular Carcinoma by Regulating Macrophages and Tumor Stem Cells
Authors: Zhang Liwei , Wang Zhiwei , Li Mingxing , Sun Peng , Bai Tao , Wang Wang , Bai Hualong , Gou Jianjun , Wang Zhiju 
Published: September 2021

ObjectivesTo identify key genes involved in vascular invasion in hepatocellular carcinoma (HCC), to describe their regulatory mechanisms, and to explore the immune microenvironment of HCC.MethodologyIn this study, the genome, transcriptome, and immune microenvironment of HCC were assessed by using multi-platform data from The Cancer Genome Atlas (n= 373) and GEO data (GSE149614). The key regulatory networks, transcription factors and core genes related to vascular invasion and prognosis were explored based on the CE mechanism. Survival analysis and gene set enrichment were used to explore pathways related to vascular invasion. Combined with single-cell transcriptome data, the distribution of core gene expression in various cells was observed. Cellular communication analysis was used to identify key cells associated with vascular invasion. Pseudo-temporal locus analysis was used to explore the regulation of core genes in key cell phenotypes. The influence of core genes on current immune checkpoint therapy was evaluated and correlations with tumor stem cell scores were explored.ResultsWe obtained a network containing 1,249 pairs of CE regulatory relationships, including 579 differential proteins, 28 non-coding RNAs, and 37 miRNAs. Three key transcription factors, ILF2, YBX1, and HMGA1, were identified, all regulated by HCG18 lncRNA. ScRNAseq showed that HCG18 co-localized with macrophages and stem cells. CIBERSORTx assessed 22 types of immune cells in HCC and found that HCG18 was positively correlated with M0 macrophages, while being negatively correlated with M1 and M2 macrophages, monocytes, and dendritic cells. Cluster analysis based on patient prognosis suggested that regulating phenotypic transformation of macrophages could be an effective intervention for treating HCC. At the same time, higher expression of HCG18, HMGA1, ILF2, and YBX1 was associated with a higher stem cell score and less tumor differentiation. Pan cancer analysis indicated that high expression of HCG18 implies high sensitivity to immune checkpoint therapy.ConclusionHCG18 participates in vascular invasion of HCC by regulating macrophages and tumor stem cells through three key transcription factors, YBX1, ILF2, and HMGA1.
Alkali-Activation of Synthetic Aluminosilicate Glass With Basaltic Composition
Authors: Alzeer Mohammad I. M. , Nguyen Hoang , Cheeseman Christopher , Kinnunen Paivo 
Published: September 2021

Alkali-activated materials (AAMs) are a potential alternative to Portland cement because they can have high strength, good durability and low environmental impact. This paper reports on the structural and mechanical characteristics of aluminosilicate glass with basalt-like compositions, as a feedstock for AAMs. The alkali-activation kinetics, microstructure, and mechanical performance of the alkali activated glass were investigated. The results show that AAMs prepared from basalt glass have high compressive strength (reaching up to 90 MPa after 7 days of hydration) compared to those made using granulated blast furnace slag (GBFS). In addition, calorimetry data show that the hydrolysis of the developed glass and subsequent polymerization of the reaction product occur at a faster rate compared to GBFS. Furthermore, the obtained results show that the alkali activation of the developed glass formed sodium aluminosilicate hydrate (N-A-S-H) intermixed with Ca aluminosilicate hydrate gel (C-A-S-H), while the alkali activation of GBFS resulted in predominantly C-A-S-H gel. The developed glass can be formed from carbonate-free and abundant natural resources such as basalt rocks or mixtures of silicate minerals. Therefore, the glass reported herein has high potential as a new feedstock of AAMs.
Improved Retinal Microcirculation After Cardiac Surgery in Patients With Congenital Heart Disease
Authors: Li Cong , Zhu Zhuoting , Yuan Haiyun , Zhong Pingting , Peng Qingsheng , Dong Xinran , Huang Manqing , Liu Baoyi , Ren Yun , Kuang Yu , Zeng Xiaomin , Yu Honghua , Yang Xiaohong 
Published: September 2021

Background:Microcirculatory changes in congenital heart disease (CHD) patients undergoing cardiac surgery are not fully understood. We aimed to investigate the changes of retinal microcirculation in CHD patients after cardiac surgery by optical coherence tomography angiography (OCTA) and explore the association between retinal microcirculation and surgical outcome.Methods:This prospective observational study consisted of 71 CHD patients aged ≥6 years undergoing cardiac surgery including 19 cyanotic CHD (CCHD) and 52 acyanotic CHD (ACHD). Optical coherence tomography angiography (OCTA) was used to measure vessel density (VD) and capillary density (CD) of radial peripapillary capillary (RPC) and peripapillary, VD of superficial capillary plexus (SCP) and deep capillary plexus (DCP), thickness of retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) preoperatively and 1 month postoperatively. Transthoracic echocardiography was conducted to measure macrocirculation.Results:In CCHD patients, VD and CD of RPC and peripapillary increased postoperatively (allP&lt; 0.05). In ACHD patients, VD of peripapillary, CD of RPC and peripapillary, and RNFL thickness increased postoperatively (allP&lt; 0.05). VD of SCP and DCP, and GCC thickness did not change significantly in CHD patients after surgery. Lower preoperative retinal microvascular density was associated with longer cardiopulmonary bypass (CPB) time and postoperative length of stay (PLOS). No correlation was found between microcirculatory and macrohemodynamic parameters (allP&gt; 0.05).Conclusions:Improved retinal microcirculation was observed after congenital cardiac surgery and impaired preoperative retinal microvasculature was associated with prolonged CPB time and PLOS, which might provide potential information about the outcome of congenital cardiac surgery.
What Can Thermal Imagery Tell Us About Glacier Melt Below Rock Debris?
Authors: Herreid Sam 
Published: September 2021

Rock debris on the surface of a glacier can dramatically reduce the local melt rate, where the primary factor governing melt reduction is debris layer thickness. Relating surface temperature to debris thickness is a recurring approach in the literature, yet demonstrations of reproducibility have been limited. Here, I present the results of a field experiment conducted on the Canwell Glacier, Alaska, United States to constrain how thermal data can be used in glaciology. These datasets include, 1) a measured sub-daily “Østrem curve” time-series; 2) a time-series of high resolution thermal images capturing several segments of different debris thicknesses including the measurements from 1); 3) a thermal profile through a 38 cm debris cover; and 4) two Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) satellite thermal images acquired within 2 and 3 min of a field-based thermal camera image. I show that, while clear sky conditions are when space-borne thermal sensors can image a glacier, this is an unfavorable time, limiting the likelihood that different thicknesses of debris will have a unique thermal signature. I then propose an empirical approach to estimate debris thickness and compare it to two recently published methods. I demonstrate that instantaneous calibration is essential in the previously published methods, where model parameters calibrated only 1 h prior to a repeat thermal image return diminished debris thickness estimates, while the method proposed here remains robust through time and does not appear to require re-calibration. I then propose a method that uses a time-series of surface temperature at one location and debris thickness to estimate bare-ice and sub-debris melt. Results show comparable cumulative melt estimates to a recently published method that requires an explicit/external estimate of bare ice melt. Finally, I show that sub-pixel corrections to ASTER thermal imagery can enable a close resemblance to high resolution, field-based thermal imagery. These results offer a deeper insight into what thermal data can and cannot tell us about surface debris properties and glacier melt.
Extracellular Vesicles Inhibit Proliferation and Invasion of Ovarian Endometrial Stromal Cells and Their Expression of SF-1, ERβ, and Aromatase
Authors: Wang XiaoQing , Wu PeiLi , Li Xin , Zeng Cheng , Zhu JingWen , Zhou YingFang , Lu Ye , Xue Qing 
Published: September 2021

ObjectiveEndometriosis is an estrogen-dependent chronic disease. The abnormal proliferation and invasion of ectopic stromal cells (ESCs) are important manifestations of endometriosis, and it is necessary to find safer and more effective treatments. Extracellular vesicles (EVs) derived from human umbilical cord mesenchymal stem cells (UC-MSCs) have been shown to be promising for the treatment of many diseases, except endometriosis. The main purpose of this study was to explore the effect of EVs derived from UC-MSCs on ESCs and evaluate the therapeutic value of EVs on endometriosis.Study DesignFollowing the successful culture and identification of UC-MSCs, we collected the medium of UC-MSCs and extracted EVs by ultracentrifugation. Then, 120 μg/mL EVs were used to stimulate ESCs, which were collected to evaluate cell proliferation and invasion and expression of the estrogen-related proteins steroidogenic factor-1 (SF-1), estrogen receptors β (ERβ), and aromatase.ResultsCompared with the control group treated with isodose phosphate buffered saline (PBS), 120 μg/mL EVs exposure significantly decreased the expression of cyclin D1 (mRNA: n = 6, P = 0.02; protein: n = 6, P = 0.000) and matrix metalloproteinase (MMP) 9 (mRNA: n = 6, P = 0.04; protein: n = 6, P = 0.000) of ESCs, which were consistent with Cell Counting Kit-8(CCK-8) results (day 0: NC: 0.29 ± 0.04, 120 μg/mL EVs: 0.28 ± 0.04; day 1: NC: 0.42 ± 0.08, 120 μg/mL EVs: 0.32 ± 0.01; day 2: NC: 0.64 ± 0.07, 120 μg/mL EVs: 0.50 ± 0.05, P = 0.000; day 3: NC: 0.82 ± 0.09, 120 μg/mL EVs: 0.65 ± 0.07, P = 0.000; day 4: NC: 0.95 ± 0.11, 120 μg/mL EVs: 0.76 ± 0.07, P = 0.012; n = 6) and Transwell experiments (n = 6, P = 0.000). In addition, the expression of SF-1 (encoded by NR5A1; mRNA: n = 6, P = 0.000; protein: n = 6, P = 0.000), ERβ (encoded by ESR2; mRNA: n = 6, P = 0.000; protein: n = 6, P = 0.000), and aromatase (encoded by CYP19A1; mRNA: n = 6, P = 0.04; protein: n = 6, P = 0.000) in ESCs decreased significantly.ConclusionTaken together, the results show that 120 μg/mL EVs derived from UC-MSCs can effectively inhibit the proliferation and invasion of ESCs, as well as their expression of SF-1, ERβ and aromatase, and thus may lead to the alleviation of endometriosis.
Berberine Acts on C/EBPβ/lncRNA Gas5/miR-18a-5p Loop to Decrease the Mitochondrial ROS Generation in HK-2 Cells
Authors: Xu Jiang , Liu Linqing , Gan Lin , Hu Yuanyuan , Xiang Ping , Xing Yan , Zhu Jie , Ye Shandong 
Published: September 2021

BackgroundBerberine (BBR) has therapeutic effect on diabetic nephropathy (DN), but its molecular mechanism is not completely clear.MethodsThe DN model was established to observe the therapeutic effect of BBR. The expression levels of lncRNA Gas5 were detected by PCR. The transcriptional regulation of CCAAT enhancer binding protein beta (C/EBPβ) on Gas5 was analyzed by chromatin immunoprecipitation quantitative PCR (ChIP-qPCR) and luciferase reporter gene assay. The targeted regulation between Gas5 and miR-18a-5p and between miR-18a-5p and C/EBPβ 3′-untranslated region (3′-UTR) was also analyzed.ResultsIn HG environment, BBR decreased the mitochondrial reactive oxygen species (ROS) generation and activated the C/EBPβ expression in HK-2 cells; C/EBPβ could combine with the reaction element on the promoter of Gas5 to promote its expression. Gas5 also inhibited the miR-18a-5p expression as competing endogenous RNA (ceRNA) and reduce the negative regulatory effect of miR-18a-5p on C/EBPβ. BBR could activate C/EBPβ/peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) signal pathway, regulate mitochondrial energy metabolism, and inhibit ROS production and apoptosis by activating C/EBPβ/Gas5/miR-18a-5p positive feedback loop in HG environment. It also showed that BBR alleviated streptozotocin (STZ) induced renal injury in DN rats in vivo.ConclusionsThis study suggested that BBR could regulate the mitochondrial ROS generation by activating the positive feedback loop of C/EBPβ/Gas5/miR-18a-5p.
An Experimental Study on the Formation of Natural Gas Hydrate With Thermodynamic Inhibitors
Authors: Wei Na , Xie Cuiying , Sun Wantong , Li Haitao , Jiang Lin , Zhang Shenghui 
Published: September 2021

Gas hydrates formed in the conditions of high pressure and low temperature in deep sea and in the process of oil and gas transportation, natural gas hydrate (NGH), will seriously affect the safety of drilling and completion operations and marine equipment and threaten the safety of drilling platform. How to prevent the hydrate formation in the process of oil and gas production and transportation has become an urgent problem for the oil and gas industry. For this reason, in view of the formation of NGH in the process of drilling and producing marine NGH, the phase equilibrium calculation research of NGH formation was carried out, the mathematical model of gas hydrate formation phase equilibrium condition was established, and the experimental research on NGH formation was carried out through adding different thermodynamic inhibitors. The experimental phenomena show that, first, the stirring speed has little effect on the inhibition of hydrate formation. Second, when the pressure is 10 MPa and the volume concentration of inhibitor is 1, 3, 5, and 7%, the supercooling degree of hydrate formation is 1.81, 8.89, 11.09, and 9.39°C, respectively. Third, when the volume concentration of inhibitor is 1, 3, 5, and 7%, the induction time of hydrate formation is 10328, 14231, 19576, and 24900 s, respectively. As the polymer molecules in the inhibitor reduce the activity of water in the system and fill the cavity structure of the hydrate, they reduce the generation conditions of NGH and break the original phase equilibrium conditions when NGH is generated, thus forming NGH at a lower temperature or higher pressure.