bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncertainty quantification and reduction using Jacobian and Hessian information
Authors: Sánchez Josefina , Otto Kevin 
Published: October 2021

Abstract
Robust design methods have expanded from experimental techniques to include sampling methods, sensitivity analysis and probabilistic optimisation. Such methods typically require many evaluations. We study design and noise variable cross-term second derivatives of a response to quickly identify design variables that reduce response variability. We first compute the response uncertainty and variance decomposition to determine contributing noise variables of an initial design. Then we compute the Hessian second-derivative matrix cross-terms between the variance-contributing noise variables and proposed design change variables. Design variable with large Hessian terms are those that can reduce response variability. We relate the Hessian coefficients to reduction in Sobol indices and response variance change. Next, the first derivative Jacobian terms indicate which design variable can shift the mean to maintain a desired nominal target value. Thereby, design changes can be proposed to reduce variability while maintaining a targeted nominal value. This workflow finds changes that improve robustness with a minimal four runs per design change. We also explore further computation reductions achieved through compounding variables. An example is shown on a Stirling engine where the top four variance-contributing tolerances and design changes identified through 16 Hessian terms generated a design with 20% less variance.
Psychiatric court reports and diversion outcomes in a remand prison over three years
Authors: Tong Kezanne , Smith Damian , Mohan Christopher , Hickey Philip , Taylor Enda , McLoughlin Lisa , Kennedy Harry G. , O’Neill Conor 
Published: October 2021

Objectives:There has been a notable increase in requests for psychiatric reports from District Courts for persons remanded to Ireland’s main remand prison, Cloverhill. We aimed to identify if reports were prepared for persons with severe mental illness and if they led to therapeutic benefits such as diversion to healthcare. Measures of equitability between Cloverhill and other District Courts were explored.Methods:For District Court-requested reports completed by the Prison Inreach and Court Liaison Service (PICLS) at Cloverhill Prison from 2015 to 2017, we recorded clinical variables and therapeutic outcomes such as diversion to inpatient psychiatric settings.Results:Of 236 cases, over half were diverted to inpatient or outpatient psychiatric care. One-third of remand episodes were admitted to a psychiatric hospital, mainly in non-forensic settings. Nearly two-thirds had major mental illness, mainly schizophrenia and related conditions. Almost half had active psychosis. Cases in Cloverhill District Court and other District Courts were similarly likely to have active psychosis (47% overall) and hospital admission (33% overall). Voluntary reports were more likely to identify active psychosis, with over 90% diverted to inpatient or outpatient community treatment settings.Conclusions:This is the first large scale study of diversion outcomes following requests for psychiatric advice from District Courts in Ireland. Requests were mainly appropriate. Over half led to diversion from the criminal justice system to healthcare settings. There is a need for a complementary network of diversion initiatives at every stage of the criminal justice system to effectively divert mentally ill individuals to appropriate settings at the earliest possible stage.
Unmitigated negative nasopharyngeal pressure is associated with attic retraction pocket formation: LaPlace's law in action
Authors: Mahajan Nilesh H , Vijayendra H , Vijayendra Vinay Kumar , Redleaf Miriam 
Published: October 2021

AbstractBackgroundDecades of clinical observation have led our subspecialty team to suspect that negative nasopharyngeal pressure is associated with attic retraction pocket formation. Furthermore, LaPlace's law, which states that the pressure within a sphere varies with the inverse of the radius, provides the dynamic explanation for why the attic area of the tympanic membrane tends to retract more frequently than the pars tensa.MethodsThe attic retraction pockets of 154 patients were classified into grades of severity (grades I–V). Impedance audiometry of middle-ear pressure was measured in the resting state, and after sniffing, swallowing and the Valsalva manoeuvre.ResultsNegative nasopharyngeal pressure (sniffing) caused a diminution of middle-ear pressure of −5 daPa on average in normal ears, and of −24 daPa to −45 daPa for tympanic membranes with attic retraction pockets of grade I to grade V.ConclusionAttic retraction pockets are associated with greater collapse of middle-ear volume when negative pressure is created in the nasopharynx. LaPlace's law, and the composition of the pars flaccida, suggests an explanation for why the attic region retracts more than the pars tensa.
Thermal Tides in the Upper Cloud Layer of Venus as Deduced From the Emission Angle Dependence of the Brightness Temperature by Akatsuki/LIR
Authors: Akiba Masahiro , Taguchi Makoto , Fukuhara Tetsuya , Imamura Takeshi , Kouyama Toru , Sato Takao M. 
Published: October 2021

AbstractThe brightness temperature of the Venus disk obtained by Longwave Infrared Camera (LIR) on board Akatsuki shows clear limb darkening at low and middle latitudes. The profile of limb brightness reflects the vertical distributions of atmospheric temperature and the optical thickness of the cloud particles. Horizontal distributions of brightness temperature obtained by LIR during ∼5.8 Venusian years were analyzed to investigate the vertical structure of the brightness temperature distribution above the cloud tops based on the emission angle dependence of the sensing altitude. Emission angles were converted to sensing altitudes by a radiative transfer calculation with nominal temperature and cloud particle distributions based on past observations. We show a local time‐altitude cross section of the brightness temperature deviation above the cloud tops for three latitudinal zones. The derived vertical amplitude distribution of the diurnal and semidiurnal tides above ∼68 km is mostly explained by the classical theory of thermal tides. A semidiurnal tide in which the phase shifts upstream with altitude is clearly seen in the equatorial region. By applying the dispersion relation of the internal gravity wave to the observed wave structure, it was found that the zonally averaged zonal wind velocity at altitudes of 66–71 km was approximately the same as the known superrotation velocity. By comparing the observed and simulated vertical phase structures, it is suggested that the tidal wave structure seen in the equatorial cloud tops is an aspect of upward propagation of a gravity wave generated in the upper cloud layer by solar heating.
Climate as the Great Equalizer of Continental‐Scale Erosion
Authors: Jepson Gilby , Carrapa Barbara , Gillespie Jack , Feng Ran , DeCelles Peter G. , Kapp Paul , Tabor Clay R. , Zhu Jiang 
Published: October 2021

AbstractCentral Asia hosts the most extensive and highest topography on Earth, which is the result of the feedbacks among rock uplift, atmospheric circulation and moisture transport, and erosion. Here, we analyze 2,511 published low‐temperature thermochronometric ages as a proxy of the regional‐scale erosion of Central Asia. We compare these ages to tectonic and climate proxies, and state‐of‐the‐art paleoclimate simulations to constrain the inﬂuences of climate and tectonics on the topographic architecture of Central Asia. We observe a ﬁrst‐order relationship between younger cooling ages in areas of high precipitation and older ages (Mesozoic) in areas that have been sheltered from precipitation, despite high strain rates. Thus, we suggest that climate enhances erosion in areas where rock uplift produces signiﬁcant orographic gradients, whereas in the continental interior, areas which are tectonically active but have been sheltered from signiﬁcant precipitation record older ages and a longer erosional history.
Ionospheric Response to Sudden Stratospheric Warming Events Across Longitudes During Solar Cycle 24
Authors: Gupta Sumedha , Upadhayaya A. K. , Siingh Devendraa 
Published: October 2021

AbstractSolar cycle 24 from December 2008 to December 2019 had an unusual progression and was the weakest cycle in a century, providing an ideal scenario to study perceivable effect of wave forcing from lower atmosphere. This study examines the ionospheric response to meteorological phenomenon of sudden stratospheric warming (SSW) during solar cycle 24 (Arctic winter 2008/2009 to 2018/2019) using Global Positioning System‐derived total electron content (VTEC) and its deviation from monthly median (ΔVTEC) for four longitudinal chains. Each chain comprises eight stations, covering varied latitudes in both hemispheres. A longitude‐ and latitude‐dependent response of VTEC is observed within ∼3 weeks of peak polar stratospheric temperature anomaly (ΔTmax), with maximum variations seen for low‐latitude stations at American and Australian‐East Asian sectors. It is seen that variations during minor warming events are comparable or at times even larger than during major warming events. These responses increase with an increase in solar activity, with major SSW events primarily seen during moderate and low solar activity periods and minor SSW during high solar activity period. Under similar ionizing conditions, a quite similar ionospheric response is observed irrespective of ΔTmax and of SSW type (major or minor); however, under similar SSW strength, no prominent pattern in ionospheric response is observed. Latitude‐dependent semidiurnal ionospheric behavior is observed for only a few events. This vertical coupling between lower and upper atmosphere during SSW is predominantly influenced by 13–16 days periodicities in VTEC, along with other periodicities of 9, 7, 5, and 3 days.
Ripples, Transverse Aeolian Ridges, and Dark‐Toned Sand Dunes on Mars: A Case Study in Terra Sabaea
Authors: Lu Y. , Edgett K. S. , Wu Y. Z. 
Published: October 2021

AbstractRipples, transverse aeolian ridges (TARs), and dark‐toned sand sheets and dunes are common aeolian bedforms on the Martian surface. They are important for understanding the nature of present‐day Martian sediments and regional aeolian processes. Here we present a case study investigation of ripples, TARs, a dark‐toned sand sheet, and dunes in an unnamed—but well‐covered by remote sensing datasets—crater in Terra Sabaea, Mars, to consider their nature and possible origin scenarios. Repeat high‐spatial resolution images show only minor albedo changes among the dark‐toned sand dunes but no obvious changes in the ripples and TARs. Visible and infrared spectra show that the megaripples and TARs are pyroxene‐bearing, while the dark‐toned sheet and dunes are olivine‐bearing. Thousands of TARs are superimposed on the crater walls, and they have a similar composition as the bedrock exposed around the central pit, suggesting that some percentage of the sediment composing the TARs may be locally derived. Megaripples have a similar composition as TARs, suggesting they may share a similar origin. Dark‐toned sand sheets and sand dunes show a different composition from the substrate of the crater, plus bedform orientations indicative of a dominant, north‐northwest wind, indicating that some of these dark sands might have been blown in from outside of the crater. Alternatively, the sand in the megaripples, TARs, sand sheets, and dunes could share a common source, and some or even all of them could be recycled from the weathering and erosion of the sand‐bearing clastic rocks exposed in the crater walls.
MYH9 is crucial for stem cell-like properties in non-small cell lung cancer by activating mTOR signaling
Authors: Chen Meng , Sun Li-Xin , Yu Long , Liu Jun , Sun Li-Chao , Yang Zhi-Hua , Shu Xiong , Ran Yu-Liang 
Published: October 2021

AbstractThe fatality rate of non-small cell lung cancer (NSCLC) has been high due to the existence of cancer stem cells (CSCs). Non-muscle myosin heavy chain 9 (MYH9) can promote the progression of various tumors, but its effect on the stem cell-like characteristics of lung cancer cells (LCCs) has not been clarified. Our research found that the stemness characteristics of LCCs were significantly enhanced by the overexpression of MYH9, and the knockout of MYH9 had the opposite effects. The in vivo with inhibitor blebbistatin further confirmed the effect of MYH9 on the stem cell-like behavior of LCCs. Furthermore, western blotting showed that the expression level of CSCs markers (CD44, SOX2, Nanog, CD133, and OCT4) was also regulated by MYH9. Mechanistic studies have shown that MYH9 regulates stem cell-like features of LCCs by regulating the mTOR signaling pathway, which was supported by sphere formation experiments after LCCs were treated with inhibitors Rapamycin and CHIR-99021. Importantly, high expression of MYH9 in lung cancer is positively correlated with poor clinical prognosis and is an independent risk factor for patients with NSCLC.
MdWRKY75e enhances resistance to Alternaria alternata in Malus domestica
Authors: Hou Yingjun , Yu Xinyi , Chen Weiping , Zhuang Weibing , Wang Sanhong , Sun Chao , Cao Lifang , Zhou Tingting , Qu Shenchun 
Published: October 2021

AbstractTheAlternaria alternataapple pathotype adversely affects apple (Malus domesticaBorkh.) cultivation. However, the molecular mechanisms underlying enhanced resistance to this pathogen in apple remain poorly understood. We have previously reported thatMdWRKY75expression is upregulated byA. alternatainfection in ‘Sushuai’ apples. In this study, we discovered that overexpression ofMdWRKY75eincreased the resistance of transgenic apple lines toA. alternatainfection, whereas silencing this gene enhanced susceptibility toA. alternatainfection. Furthermore, we found that MdWRKY75e directly binds to theMdLAC7promoter to regulate the biosynthesis of laccase and increase the biosynthesis of lignin duringA. alternatainfection. Moreover, the thickening of the cell wall enhanced the mechanical defense capabilities of apple. In addition, we found that jasmonic acid remarkably inducedMdWRKY75eexpression, and its levels in transgenic apple lines were elevated. These results indicate thatMdWRKY75econfers resistance to theA. alternataapple pathotype mainly via the jasmonic acid pathway and that pathogenesis-related genes and antioxidant-related enzyme activity are involved in the disease resistance ofMdWRKY75etransgenic plants. In conclusion, our findings provide insights into the importance ofMdWRKY75efor resistance toA. alternatainfection in apples.
Immune cell infiltration signatures identified molecular subtypes and underlying mechanisms in gastric cancer
Authors: Lin Yilin , Pan Xiaoxian , Zhao Long , Yang Changjiang , Zhang Zhen , Wang Bo , Gao Zhidong , Jiang Kewei , Ye Yingjiang , Wang Shan , Shen Zhanlong 
Published: October 2021

AbstractIncreasing evidence has clarified that the tumor microenvironment (TME) is closely related to the prognosis and therapeutic efficacy of cancer. However, there is no reliable TME evaluation system used to accurately predict the prognosis of and therapeutic efficacy in gastric cancer. We evaluated the immune microenvironment score (IMS) of 1422 gastric cancer samples based on 51 immune cell signatures. We explored the relationship between the IMS and prognosis, immune cell infiltration, cancer subtype, and potential immune escape mechanisms. The results show that activation of the stroma and decreased levels of immune infiltration were associated with a low IMS. A high IMS was characterized by Epstein–Barr virus infection, increased mutation load, microsatellite instability, and immune cell infiltration. A high IMS was also related to high expression of immune checkpoint molecules (PD-1/PD-L1). Finally, patients with a high IMS had a better response to PD-1/PD-L1 inhibitors and may be more suitable for immune checkpoint inhibitors (area under the curve = 0.81). In addition, a low IMS may be converted into the immune-infiltrating subtype after romidepsin treatment. Stratification based on the IMS may enable gastric cancer patients to benefit more from immunotherapy and help identify new cancer treatment strategies.
Neurofilament light chain and α-synuclein RT-QuIC as differential diagnostic biomarkers in parkinsonisms and related syndromes
Authors: Quadalti Corinne , Calandra-Buonaura Giovanna , Baiardi Simone , Mastrangelo Andrea , Rossi Marcello , Zenesini Corrado , Giannini Giulia , Candelise Niccolò , Sambati Luisa , Polischi Barbara , Plazzi Giuseppe , Capellari Sabina , Cortelli Pietro , Parchi Piero 
Published: October 2021

AbstractNeurofilament light chain (NfL) and α-synuclein oligomeric seeds (α-syn-s) are promising biomarkers for patients with parkinsonism. We assessed their performance in discriminating Parkinson disease (PD) from atypical parkinsonisms (APDs) and evaluated the association between NfL levels and clinical measures of disease severity. We measured NfL in cerebrospinal fluid (CSF) and/or plasma by immunoassays and α-syn-s in CSF by real-time quaking-induced conversion (RT-QuIC) in patients with PD (n = 153), multiple system atrophy (MSA) (n = 80), progressive supranuclear palsy/cortico-basal syndrome (PSP/CBS) (n = 58), dementia with Lewy bodies (n = 64), isolated REM-sleep behaviour disorder (n = 19), and isolated autonomic failure (n = 30). Measures of disease severity included disease duration, UPDRS-III score, Hoehn and Yahr stage, orthostatic hypotension, MMSE score, and CSF amyloid-beta profile. Both CSF NfL (cNfL) and plasma NfL (pNfL) levels were markedly elevated in APDs, and allowed differentiation with PD (vs. APDs, cNfL AUC 0.96; pNfL AUC 0.95; vs. MSA cNfL AUC 0.99; pNfL AUC 0.97; vs. PSP/CBS cNfL AUC 0.94; pNfL AUC 0.94). RT-QuIC detected α-syn-s in 91.4% of PD, but only 2.5% of APDs (all MSA). In PD/PDD, motor scales significantly correlated with cNfL levels. Although pNfL and both cNfL and α-syn-s accurately distinguished PD from APDs, the combined assessment of CSF markers provided a higher diagnostic value (PD vs. APDs AUC 0.97; vs. MSA AUC 0.97; vs. PSP/CBS AUC 0.99) than RT-QuIC alone (p = 0.047 vs. APDs;p = 0.002 vs MSA;p = 0.007 vs PSP/CBS), or cNfL alone (p = 0.011 vs. APDs;p = 0.751 vs MSA;p = 0.0001 vs. PSP/CBS). The results support the use of these assays in specialised clinics.
First delirium episode in Parkinson’s disease and parkinsonism: incidence, predictors, and outcomes
Authors: Green Samantha , Perrott Sarah L. , McCleary Andrew , Sleeman Isobel , Maple-Grødem Jodi , Counsell Carl E. , Macleod Angus D. 
Published: October 2021

AbstractTo define the incidence, predictors and prognosis of the first hospital delirium episode in Parkinson’s disease (PD) and atypical parkinsonism (AP), we identified the first hospital episode of delirium after diagnosis in the Parkinsonism Incidence in North-East Scotland (PINE) study, a prospective community-based incidence cohort of parkinsonism, using chart-based criteria to define delirium. Of 296 patients (189=PD, 107=AP [dementia with Lewy bodies, progressive supranuclear palsy, multiple system atrophy, vascular parkinsonism]), 152 developed delirium (PD = 98, AP = 54). Incidence of first hospital delirium episode per 100 person years was 8.1 (95% confidence interval [CI] 6.6–9.9) in PD and 18.5 (95% CI 13.9–24.7) in AP. Independent predictors of delirium were atypical parkinsonism (Hazard ratio [HR] vs PD = 2.83 [95% CI 1.60–5.03], age in PD but not in AP (HR for 10-year increase 2.29 [95% CI 1.74–3.02]), baseline MMSE (HR = 0.94 [95% CI 0.89–0.99]), APOE ε4 in PD (HR 2.16 [95% CI 1.15–4.08]), and MAPT H1/H1 in PD (HR 2.08 [95% CI 1.08–4.00]). Hazards of dementia and death after delirium vs before delirium were increased (dementia: HR = 6.93 [95% CI 4.18–11.48] in parkinsonism; death: HR = 3.76 [95% CI 2.65–5.35] in PD, 1.59 [95% CI 1.04–2.42] in AP). Delirium is a common non-motor feature of PD and AP and is associated with increased hazards of dementia and mortality. Whether interventions for early identification and treatment improve outcomes requires investigation.
Full monitoring of ensemble trajectories with 10 dB-sub-Heisenberg imprecision
Authors: Zander Jascha , Schnabel Roman 
Published: October 2021

AbstractThe change of a quantum state can generally only be fully monitored through simultaneous measurements of two non-commuting observables $$\hat{X}$$

X

̂

and $$\hat{Y}$$

Y

̂

spanning a phase space. A measurement device that is coupled to the thermal environment provides at a time a pair of values that have a minimal uncertainty product set by the Heisenberg uncertainty relation, which limits the precision of the monitoring. Here, we report on an optical ensemble measurement setup that is able to monitor the time-dependent change of the quantum state’s displacement in phase space ($$\langle \hat{X}(t)\rangle ;\langle \hat{Y}(t)\rangle$$

⟨

X

̂

(

t

)

⟩
;
⟨

Y

̂

(

t

)

⟩

) with an imprecision 10 dB below the Heisenberg uncertainty limit. Our setup provides pairs of values (X(ti); Y(ti)) from simultaneous measurements at subsequent times ti. The measurement references are not coupled to the thermal environment but are established by an entangled quantum state. Our achievement of a tenfold reduced quantum imprecision in monitoring arbitrary time-dependent displacements supports the potential of the quantum technology required for entanglement-enhanced metrology and sensing as well as measurement-based quantum computing.
The neuroscience of advanced scientific concepts
Authors: Mason Robert A. , Schumacher Reinhard A. , Just Marcel Adam 
Published: October 2021

AbstractCognitive neuroscience methods can identify the fMRI-measured neural representation of familiar individual concepts, such as apple, and decompose them into meaningful neural and semantic components. This approach was applied here to determine the neural representations and underlying dimensions of representation of far more abstract physics concepts related to matter and energy, such as fermion and dark matter, in the brains of 10 Carnegie Mellon physics faculty members who thought about the main properties of each of the concepts. One novel dimension coded the measurability vs. immeasurability of a concept. Another novel dimension of representation evoked particularly by post-classical concepts was associated with four types of cognitive processes, each linked to particular brain regions: (1) Reasoning about intangibles, taking into account their separation from direct experience and observability; (2) Assessing consilience with other, firmer knowledge; (3) Causal reasoning about relations that are not apparent or observable; and (4) Knowledge management of a large knowledge organization consisting of a multi-level structure of other concepts. Two other underlying dimensions, previously found in physics students, periodicity, and mathematical formulation, were also present in this faculty sample. The data were analyzed using factor analysis of stably responding voxels, a Gaussian-naïve Bayes machine-learning classification of the activation patterns associated with each concept, and a regression model that predicted activation patterns associated with each concept based on independent ratings of the dimensions of the concepts. The findings indicate that the human brain systematically organizes novel scientific concepts in terms of new dimensions of neural representation.