bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic surgery for median arcuate ligament syndrome using real‐time stereotactic navigation
Authors: Aisu Yuki , Okada Tomoaki , Sumii Atsuhiko , Ganeko Riki , Okamura Ryosuke , Nishigori Tatsuto , Itatani Yoshiro , Hisamori Shigeo , Tsunoda Shigeru , Hida Koya , Kawada Kenji , Obama Kazutaka , Sakai Yoshiharu 
Published: September 2021

AbstractIntroductionIn median arcuate ligament syndrome (MALS), a hyperplastic MAL causes compression and stenosis of the celiac artery (CA). The treatment involves releasing the external pressure on this artery by dissecting the ligament. However, it is difficult to identify the artery because of its deep anatomical location. Stereotactic navigation provides real‐time information regarding the surgical instrument's location on computed tomography (CT) images. We utilized this system to overcome the difficulty of anatomical identification.Materials and Surgical TechniqueWe present a case of aneurysm rupture caused by MALS, which was treated with laparoscopic MAL dissection with real‐time stereotactic navigation. Surgery was performed in a hybrid operating room with three‐dimensional C‐arm CT (Artis Zeego, Siemens) and an installed Curve navigation system (BrainLab). Preoperative CT images were aligned with intraoperative C‐arm CT‐like images and the surgical instrument position was projected onto preoperative CT images. After the left gastric artery isolation, the fibrous tissue surrounding the left gastric artery was dissected toward the CA while confirming the location of the CA and aortic wall using the navigation system. The CA's diameter was dilated from 1.8 to 2.6 mm with intraoperative angiography.DiscussionThis is the first report of laparoscopic MAL dissection using real‐time stereotactic navigation. Although navigation setting was time‐intensive, this system helped us understand the anatomical structures and in safely and precisely dissecting the MAL.
Factors associated with small lungworm infections in heavily infected sheep in southeast South Australia
Authors: Hanks JE , Larsen JWA , Campbell AJD 
Published: September 2021

This field observational study describes the seasonal pattern of small lungworm infections under different grazing managements from August 2018 to March 2019. Live weight, lungworm and gastrointestinal nematode infection, as well as pasture type grazed and snail density, were measured at 5 farm visits. Across all visits and mobs, about one quarter to one half of sheep were positive for small lungworm, although prevalence was as low as 0% and as high as 78%. The density of the intermediate host molluscs was greater than 1600 snails/m2 in irrigated perennial lucerne pasture when it was grazed (‘Pasture A’), but was low (<300) in non‐irrigated perennial pasture (‘Pasture B’) and non‐irrigated forage crop (‘Pasture C’). Overall, non‐infected lambs had a similar live weight compared with the small lungworm infected lambs (mean difference −0.6 kg; 95% CI −1.6 to 0.2; P = 0.1). The odds ratio of small lungworm infection associated with a twofold increase in worm egg count was 1.7 (95% CI 1.1 to 2.7; P = 0.02). Rather than a distinct seasonal pattern of infection, we found that small lungworm can occur throughout the year, with prevalence most influenced by pasture type (irrigated vs dryland), grazing management and the population density of the intermediate hosts. Importantly, this study suggested that small lungworm infection did not reduce lamb live weights. It reinforced that to improve sheep productivity, well‐established determinants of production, such as correct grazing management to optimise pasture quality and strategies to reduce infections with gastrointestinal nematodes, should be the priority of farm managers.
Global prevalence of depression and elevated depressive symptoms among adolescents: A systematic review and meta‐analysis
Authors: Shorey Shefaly , Ng Esperanza Debby , Wong Celine H. J. 
Published: September 2021

ObjectiveAdolescence is a formative and turbulent phase where physiological, psychosocial, and cognitive changes leave adolescents vulnerable to psychological disorders. Given the lack of reviews that consolidate and compare worldwide prevalence of depression among adolescents, this review aims to examine the global prevalence of major depressive disorders, dysthymia, and elevated depressive symptoms among adolescents.MethodsA systematic review and meta‐analysis was conducted. Six databases were searched for studies published from 2001 to December 2020. Seventy‐two studies were included. Subgroup analysis were performed for year of publication, geographical region, gender, and assessment tools used.ResultsThe global point prevalence rate of elevated self‐reported depressive symptoms from 2001 to 2020 was 34% (95% CI: 0.30–0.38). Point prevalence for major depressive disorder (MDD) and dysthymia was 8% (95% CI: 0.02–0.13) and 4% (95% CI: 0.01–0.07), respectively. The pooled one‐year prevalence and lifetime prevalence for MDD were 8% (95% CI: 0.05–0.12) and 19% (95% CI: 0.12–0.26). Point prevalence of elevated depressive symptoms among adolescents increased from 24% (95% CI: 0.19–0.28) between 2001 and 2010 to 37% (95% CI: 0.32–0.42) between 2011 and 2020. The Middle East, Africa, and Asia have the highest prevalence of elevated depressive symptoms, and female adolescents were reported to have a higher prevalence of elevated depressive symptoms than male adolescents.ConclusionBesides targeting those with existing clinical depression, research and policies should also focus on educational and supportive mitigation efforts to curb depressive symptoms among adolescents before escalation. The findings encourage future research to develop more gender‐specific and culturally relevant intervention programmes.Practitioner points34% of adolescents globally, aged 10‐19 years, are at risk of developing clinical depression, which exceeds the reported estimates of individuals aged 18 to 25 years. Practitioners are highly encouraged to prioritize depression screening and intervention implementation for individuals in this age group.Female adolescents and adolescents from Middle East, Africa, and Asia have the highest risk of developing depression. This urges practitioners and researchers to develop more gender‐specific and culturally relevant intervention programmes.
TEA domain transcription factor 4 modulates repression of fetal haemoglobin by direct binding to the γ‐globin gene promoters
Authors: Lin Jiaqiong , Ye Yuhua , Shang Xuan , Zhang Yanxia , Wei Xiaofeng , Xu Xiangmin 
Published: September 2021

SummaryRe‐activation of fetal haemoglobin (HbF) has been proved to be an effective strategy for the treatment of β‐haemoglobinopathies. In this study, we identified TEA domain transcription factor 4 (TEAD4) as a new potential regulator of HbF by integrating public data sets with quantitative polymerase chain reaction analysis in β‐thalassaemia patients. Significant negative correlation was observed between the expression of TEAD4 and HbF levels in β‐thalassaemia patients. Functional validations of TEAD4 inhibition in both β‐thalassaemia CD34+ cells and HUDEP‐2 cells indicated that depletion of TEAD4 led to a significant increase of HbF. Finally, we identified a binding motif of TEAD4 on γ‐globin gene promoters; its disruption consistently led to de‐repression of HbF. Taken together, these results demonstrate that TEAD4 could act as a transcriptional inhibitor of the γ‐globin gene through direct binding on its promoter. Our findings demonstrate a novel role of TEAD4 on the regulation of HbF, which may benefit patients with β‐haemoglobinopathies.
Bi‐allelic mutations in MCIDAS and CCNO cause human infertility associated with abnormal gamete transport
Authors: Ma Cong , Wu Huan , Zhu Damin , Wang Ying , Shen Qunshan , Cheng Huiru , Zhang Junqiang , Geng Hao , Liu Yiyuan , He Xiaojin , Tao Fangbiao , Cao Yunxia , Xu Xiaofeng 
Published: September 2021

AbstractReduced generation of multiple motile cilia (RGMC) and the consequent primary ciliary dyskinesia (PCD) cause infertility due to a substantial reduction in the number of multiciliated cells (MCCs) in the efferent ducts (EDs)/oviducts. MCIDAS acts upstream of CCNO to regulate the biogenesis of basal bodies (BBs); therefore, both genes play a vital role in the multiciliogenesis of the reproductive tract epithelium. In this study, whole‐exome sequencing was performed to identify the causative genes in 10 unrelated infertile patients with PCD: seven males and three females. Notably, homozygous frameshift mutations in MCIDAS (c.186dupT, p.Pro63Serfs*22) and CCNO (c.262_263insGGCCC, p.Gln88Argfs*8) were identified in one male and one female participant from two unrelated consanguineous families. Haematoxylin–eosin staining/scanning electron microscopy revealed abnormal MCCs in the mutated EDs/oviducts. Furthermore, transmission electron microscopy revealed significantly reduced BBs. Immunofluorescence staining showed the absence of MCIDAS and CCNO signals in the affected tissues and confirmed that MCIDAS acts upstream of CCNO in the context of multiciliogenesis in the reproductive tract epithelium. In vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) was successful, with a positive pregnancy outcome in both MCIDAS‐ and CCNO‐mutated patients. Our results support the use of IVF/ICSI interventions to treat infertility due to RGMC in couples.
Suspension laryngoscopy experiences in a tertiary airway service: A prospective study of 150 procedures
Authors: Maughan Elizabeth F. , Rotman Anthony , Rouhani Maral J. , Thong Gerard , Poncia James , Myatt John , Al Yaghchi Chadwan , Sandhu Gurpreet 
Published: September 2021

AbstractObjectivesIn most cases, suspension laryngoscopy (SL) is efficient, bloodless and with minimal post‐procedure discomfort. We aimed to identify predictive patient factors for acceptable surgical views at SL as well as quantify our tertiary airway unit's complication rates.DesignProspective cohort study of 150 consecutive microlaryngoscopy procedures involving SL over an 8‐month period between November 2019 and July 2020. Patients were assessed preoperatively for pre‐existing oral, temporomandibular, dental, pharyngeal or laryngeal pathology, interincisor distance and qualitative gross limitations to neck extension and forward head posture. Intraoperatively, the laryngoscopic view was graded by anaesthetic and surgical teams, and complications were recorded on patient interview in recovery.SettingTertiary adult airway service for predominantly benign pathology.ResultsAdequate surgical views were obtained in 149/150 procedures. BMI had a weak positive correlation with a more difficult view (r = .22, p = .008) but did not correlate with a statistically significant increase in any complication. There was a weak negative correlation between age and interincisor gap (r = −.20, p = .014), and wider mouth opening correlated very weakly with a lower incidence of sore throat (r = −.19, p = .023). Gross macroglossia showed a significant moderate positive correlation with tongue symptoms (r = .45, p = 1.611 × 10−8).ConclusionIn the context of an experienced airway unit with a high caseload of predominantly benign pathology, SL is very effective and safe with low associated morbidity and no mortality. The most common complication of SL is temporary sore throat and there remain recognised risks of temporary tongue and dental symptoms.
Corneal nerve loss is related to the severity of painful diabetic neuropathy
Authors: Kalteniece Alise , Ferdousi Maryam , Azmi Shazli , Khan Saif Ullah , Worthington Anne , Marshall Andrew , Faber Catharina G. , Lauria Giuseppe , Boulton Andrew J. M. , Soran Handrean , Malik Rayaz A. 
Published: September 2021

AbstractBackground and purposePreviously it has been shown that patients with painful diabetic neuropathy (PDN) have greater corneal nerve loss compared to patients with painless diabetic neuropathy. This study investigated if the severity of corneal nerve loss was related to the severity of PDN.MethodsParticipants with diabetic neuropathy (n = 118) and healthy controls (n = 38) underwent clinical and neurological evaluation, quantitative sensory testing, nerve conduction testing and corneal confocal microscopy and were categorized into those with no (n = 43), mild (n = 34) and moderate‐to‐severe (n = 41) neuropathic pain.ResultsCorneal nerve fibre density (p = 0.003), corneal nerve fibre length (p < 0.0001) and cold perception threshold (p < 0.0001) were lower and warm perception threshold was higher (p = 0.002) in patients with more severe pain, but there was no significant difference in the neuropathy disability score (p = 0.5), vibration perception threshold (p = 0.5), sural nerve conduction velocity (p = 0.3) and amplitude (p = 0.7), corneal nerve branch density (p = 0.06) and deep breathing heart rate variability (p = 0.08) between patients with differing severity of PDN. The visual analogue scale correlated significantly with corneal nerve fibre density (r = −0.3, p = 0.0002), corneal nerve branch density (r = −0.3, p = 0.001) and corneal nerve fibre length (r = −0.4, p < 0.0001). Receiver operating curve analysis showed that corneal nerve fibre density had an area under the curve of 0.78 with a sensitivity of 0.73 and specificity of 0.72 for the diagnosis of PDN.ConclusionsCorneal confocal microscopy reveals increasing corneal nerve fibre loss with increasing severity of neuropathic pain and a good diagnostic outcome for identifying patients with PDN.
First report of Aulacaspis rosae (Bouché, 1833) (Diaspididae) in Tunisia
Authors: Ben Halima Kamel Monia , Zouari Sana , Ben Cheick Zohra , Adouani Rihem , Germain Jean François 
Published: September 2021

AbstractIn 2017 and 2018, from June to October, unusual damage was observed on Japanese sago palm (Cycas revoluta) (Cycadaceae), in several towns in Tunisia: Ariana (Ariana governorate), Tunis (Tunis governorate), and Akouda and Chott Mariem (Sousse Governorate). Leaf samples were collected and brought to the laboratory for observation. Morphological identification confirmed the presence of Aulacaspis rosae (Diaspididae). This is the first record of A. rosae in Tunisia.
Neurovascular variations in the proximal plantar metatarsal region of the horse
Authors: Milner Peter I. , Dimmock Oliver , Barnes Kate 
Published: September 2021

SummaryBackgroundNeurovascular variation may be relevant when performing surgical techniques to the proximal plantar metatarsal region.ObjectivesTo document variations in the neurovascular anatomy of the proximal plantar metatarsal region and study the relationship of the neurovascular components to each other and other structures located in this area.Study designDescriptive anatomical study.MethodsPaired cadaver hind limbs from 15 horses were dissected from the distal tibia to the metatarsophalangeal joint. Deep branch of the lateral plantar nerve (DBLPN) length, location of its origin from the lateral plantar nerve (LPN), individual DBLPN ramifications into the suspensory ligament (SL) and relationship of the DBLPN to the plantar arch and accessory ligament of the deep digital flexor tendon (ALDDFT) were recorded.ResultsMean DBLPN length was 5.8 ± 1.7 cm with the nerve arising 3.7 ± 1.5 cm proximal to the head of the fourth metatarsal bone (MTIV). There was a median of three individual DBLPN ramifications (range 2‐6) entering the SL. There were no significant left/right differences. In 57% (CI 39%‐74%; n = 17) limbs, the deep plantar arch was superficial to the DBLPN, whereas in 33% (CI 16%‐50%; n = 10) limbs, the DBLPN passed between the venous and arterial components of the arch. In 10% (CI 1%‐20%; n = 3) limbs, the deep plantar arch was deep to the DBLPN. In 67% (CI 50%‐84%; n = 20) limbs, the DBLPN was superficial to the ALDDFT, whereas in 33% (CI 16%‐50%; n = 10) limbs, the nerve ran deep to the ALDDFT. An additional branch from the LPN was noted in one limb.Main limitationsLimbs were used from horses with unknown clinical history.ConclusionsAnatomical variation, in particular the relationship of the DBLPN and deep metatarsal fascia to the deep plantar arch and the ALDDFT is an important consideration when undertaking surgical approaches to the proximal plantar metatarsal region.
Evolutionary state‐based novel multi‐objective periodic bacterial foraging optimization algorithm for data clustering
Authors: Guo Chen , Tang Heng , Niu Ben 
Published: September 2021

AbstractClustering divides objects into groups based on similarity. However, traditional clustering approaches are plagued by their difficulty in dealing with data with complex structure and high dimensionality, as well as their inability in solving multi‐objective data clustering problems. To address these issues, an evolutionary state‐based novel multi‐objective periodic bacterial foraging optimization algorithm (ES‐NMPBFO) is proposed in this article. The algorithm is designed to alleviate the high‐computing complexity of the standard bacterial foraging optimization (BFO) algorithm by introducing periodic BFO. Moreover, two learning strategies, global best individual (gbest) and personal historical best individual (pbest), are used in the chemotaxis operation to enhance the convergence speed and guide the bacteria to the optimum position. Two elimination‐dispersal operations are also proposed to prevent falling into local optima and improve the diversity of solutions. The proposed algorithm is compared with five other algorithms on six validity indexes in two data clustering cases comprising nine general benchmark datasets and four credit risk assessment datasets. The experimental results suggest that the proposed algorithm significantly outperforms the competing approaches. To further examine the effectiveness of the proposed strategies, two variants of ES‐NMPBFO were designed, and all three forms of ES‐NMPBFO were tested. The experimental results show that all of the proposed strategies are conducive to the improvement of solution quality, diversity and convergence.
Multi‐start iterated local search metaheuristic for the multi‐mode resource‐constrained project scheduling problem
Authors: Ramos Alfredo S. , Olivares‐Benitez Elias , Miranda‐Gonzalez Pablo A. 
Published: September 2021

AbstractIn this paper a multi‐start iterated local search (MS‐ILS) algorithm is presented as a new and effective approach to solve the multi‐mode resource‐constrained project scheduling problem (MRCPSP). The MRCPSP is a well‐known project scheduling NP‐Hard optimization problem, in which there is a trade‐off between the duration of each project activity and the amount of resources they require to be completed. The proposed algorithm generates an initial solution, performs a local search to obtain a local optimum, subsequently, for a certain number of iterations, makes a perturbation to that local optimum and performs a new local search on the perturbed solution. This whole process then restarts with a different initial solution for a certain number of restarts. The algorithm was tested on benchmark instances of projects with 30, 50 and 100 activities from well‐known libraries. The obtained results were compared to recent benchmark results from the literature. The proposed algorithm outperforms other solution methods found in related literature for the largest tested instances (100 activities), while for smaller instances it shows to be quite competitive, in terms of the average deviation against known lower bounds.
Can small‐scale fisheries survive market‐based management? Nordic evidence
Authors: Nielsen Max , Andersen Peder , Asche Frank , Ellefsen Hans , Hammarlund Cecilia , Hoff Ayoe , Kristofersson Dadi Mar , Nielsen Rasmus , Rógvi Heri á , Roll Kristin , Sævaldsson Hordur , Virtanen Jarno , Waldo Staffan 
Published: September 2021

AbstractMarket‐based fisheries management systems give incentives to reduce the fleet size and employment, which increases earnings and contributes to resolve the tragedy of the commons. However, the often‐stated expectation that economies of scale cause the disappearance of small‐scale fishery is not observed in many cases. In this study, we investigate the effects on fleet structure in the period after introducing individual fishing quotas or individual fishing days with various degrees of transferability in selected fisheries in the seven Nordic countries. Despite observing economies of scale in most cases, it is found that the market‐based fisheries management often does not reduce the small‐scale fleet more than the fleet of large vessels. This is explained partly by small vessels targeting demersal species and large vessels pelagic species, and partly by the larger need of larger than small vessels to continuously utilize their capital stocks through fast adaptation to ensure return. A more important explanation is the regulation design, with limitations in sale of fishing rights and lease between vessel groups and regions and in the share of the total quota holdings of fishing rights by individuals and vessels. This is important for countries considering the introduction of market‐based fisheries management, since the Nordic experiences show that with proper regulation design, economic gains can be achieved with small‐scale fishing surviving even under economies of scale.
Role of perceived social support in the relationship between parent temperament and distress tolerance
Authors: Morford Alexandra E. , Jordan Neil , Risser Heather J. 
Published: September 2021

AbstractObjectiveTo evaluate whether social support mediates the relationships between parent temperament and distress tolerance (DT) in mothers and fathers.BackgroundDistress tolerance is central to many of the factors identified as high‐risk for parents perpetrating child maltreatment. To create effective parenting programs aimed at reducing child maltreatment, it is essential to understand the risk and protective factors associated with parental DT. Additionally, examining these factors in both mothers and fathers is important for determining whether mechanisms of risk and protective factors function similarly.MethodUsing existing cross‐sectional data, self‐report assessments from 584 parents (67% female, Mage = 32.35 years) of children between the ages of 6 months and 10 years were analyzed using mediation analyses.ResultsPerceived social support partially mediated the relationship between negative affect and distress tolerance, in the overall sample and in mothers only, but not for fathers only. Perceived social support was not a mediator of the relationship between effortful control and distress tolerance in any of the samples.ConclusionResults suggest that negative affect and perception of social support play important roles in parents’ DT capabilities. Furthermore, the inconsistency across genders, suggests that risk and protective factors of DT may differ for mothers and fathers.ImplicationsInvestigating risk factors of low parental DT is important for advancing knowledge about parents who may ultimately engage in child maltreatment to inform the design of prevention and early intervention parenting programs.
Etiology and device therapy in complete atrioventricular block in pediatric and young adult population: Contemporary review and new perspectives
Authors: Cioffi Giacomo M. , Gasperetti Alessio , Tersalvi Gregorio , Schiavone Marco , Compagnucci Paolo , Sozzi Fabiola B. , Casella Michela , Guerra Federico , Dello Russo Antonio , Forleo Giovanni Battista 
Published: September 2021

AbstractComplete atrioventricular block (CAVB) is a total dissociation between the atrial and ventricular activity, in the absence of atrioventricular conduction. Several diseases may result in CAVB in the pediatric and young‐adult population. Permanent right ventricular (RV) pacing is required in permanent CAVB, when the cause is neither transient nor reversible. Continuous RV apical pacing has been associated with unfavorable outcomes in several studies due to the associated ventricular dyssynchrony. This study aims to summarize the current literature regarding CAVB in the pediatric and young adult population and to explore future treatment perspectives.