bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microphysics and Optical Attenuation in Fog: Observations from Two Coastal Sites
Authors: Wang Qing , Yamaguchi Ryan T. , Kalogiros John A. , Daniels Zachary , Alappattu Denny P. , Jonsson Haflidi , Alvarenga Oswaldo , Olson Alex , Wauer Benjamin J. , Ortiz-Suslow David G. , Fernando Harindra Joseph 
Published: October 2021

AbstractA total of 15 fog events from two field campaigns are investigated: the High Energy Laser in Fog (HELFOG) project (central California) and the Toward Improving Coastal Fog Prediction (C-FOG) project (Ferryland Newfoundland). Nearly identical sensors were used in both projects to sample fog droplet-size spectra, wind, turbulence, and thermodynamic properties near the surface. Concurrent measurements of visibility were made by the present weather detector in both experiments, with the addition of a two-ended transmissometer in the HELFOG campaign. The analyses focused first on contrasting the observed fog microphysics and the associated thermodynamics from fog events in the two locations. The optical attenuation by fog was investigated using three methods: (1) derived from Mie theory using the measured droplet-size distribution, (2) parametrized as a function of fog liquid water content, and (3) parametrized in terms of total fog droplet number concentration. The consistency of these methods was investigated. The HELFOG data result in an empirical relationship between the meteorological range and liquid water content. Validation of such relationship is problematic using the C-FOG data due to the presence of rain and other factors. The parametrization with droplet number concentration only does not provide a robust visibility calculation since it cannot represent the effects of droplet size on visibility. Finally, a preliminary analysis of the mixed fog/rain case is presented to illustrate the nature of the problem to promote future research.
Bring Your Non-self to Work? The Interaction Between Self-decentralization and Moral Reasoning
Authors: Vu Mai Chi , Burton Nicholas 
Published: October 2021

AbstractSpirituality continues to exert a strong influence in people’s lives both in work and beyond. However, given that spirituality is often non-formalized and personal, we continue to know little about how moral reasoning is strategized. In this paper, we examine how Buddhist leader-practitioners interpret and operationalize a process of self-decentralization based upon Buddhist emptiness theory as a form of moral reasoning. We find that Buddhist leader-practitioners share a common understanding of a self-decentralized identity and operationalize self-decentralization through two practices in Buddhist philosophy—skillful means and the middle way—to foreground social outcomes. However, we also find that practitioners face tensions and challenges in moral reasoning relates to agency—the ‘re-centering’ of the self as an enlightened self and the use of karmic reasoning to justify (un)ethical behavior—and contextual constraints that lead to feelings of vulnerability and exclusion. We present a model that elaborates these processes and invite further research that examines novel approaches and dynamic interpretations of the self in moral reasoning.
Systematic review of the receptor tyrosine kinase superfamily in neuroblastoma pathophysiology
Authors: Rozen Esteban Javier , Shohet Jason Matthew 
Published: October 2021

AbstractBackgroundNeuroblastoma is a devastating disease accounting for 15% of all childhood cancer deaths. Yet, our understanding of key molecular drivers such as receptor tyrosine kinases (RTKs) in this pathology remains poorly clarified. Here, we provide a systematic analysis of the RTK superfamily in the context of neuroblastoma pathogenesis.MethodsStatistical correlations for all RTK family members’ expression to neuroblastoma patient survival across 10 independent patient cohorts were annotated, synthesized, and ranked using the R2: Genomics Analysis and Visualization Platform. Gene expression of selected members across different cancer cell lines was further analyzed in the Cancer Cell Line Encyclopedia, part of the Cancer Dependency Map portal (depmap portal (http://depmap.org)). Finally, we provide a detailed literature review for highly ranked candidates.ResultsOur analysis defined two subsets of RTKs showing robust associations with either better or worse survival, constituting potential novel players in neuroblastoma pathophysiology, diagnosis, and therapy. We review the available literature regarding the oncogenic functions of these RTKs, their roles in neuroblastoma pathophysiology, and potential utility as therapeutic targets.ConclusionsOur systematic analysis and review of the RTK superfamily in neuroblastoma pathogenesis provides a new resource to guide the research community towards focused efforts investigating signaling pathways that contribute to neuroblastoma tumor establishment, growth, and/or aggressiveness and targeting these druggable molecules in novel therapeutic strategies.
Firm Liability When Third Parties and Consumers Incur Cumulative Harm
Authors: Friehe Tim , Langlais Eric , Schulte Elisabeth 
Published: October 2021

AbstractThis paper analyzes liability rules when consumers and third parties/the environment incur harm. Expected harm is convex in the level of output and modeled as a power function. We show that the social ranking of liability rules previously established for the case in which only consumers suffer harm (Strict Liability dominates No Liability and Negligence) may be reversed if harm to third parties or the environment is sufficiently important.
The in-situ exploration of Jupiter’s radiation belts
Authors: Roussos Elias , Allanson Oliver , André Nicolas , Bertucci Bruna , Branduardi-Raymont Graziella , Clark George , Dialynas Konstantinos , Dandouras Iannis , Desai Ravindra T. , Futaana Yoshifumi , Gkioulidou Matina , Jones Geraint H. , Kollmann Peter , Kotova Anna , Kronberg Elena A. , Krupp Norbert , Murakami Go , Nénon Quentin , Nordheim Tom , Palmaerts Benjamin , Plainaki Christina , Rae Jonathan , Santos-Costa Daniel , Sarris Theodore , Shprits Yuri , Sulaiman Ali , Woodfield Emma , Wu Xin , Yao Zonghua 
Published: October 2021

AbstractJupiter has the most complex and energetic radiation belts in our Solar System and one of the most challenging space environments to measure and characterize in-depth. Their hazardous environment is also a reason why so many spacecraft avoid flying directly through their most intense regions, thus explaining how Jupiter’s radiation belts have kept many of their secrets so well hidden, despite having been studied for decades. In this paper we argue why these secrets are worth unveiling. Jupiter’s radiation belts and the vast magnetosphere that encloses them constitute an unprecedented physical laboratory, suitable for interdisciplinary and novel scientific investigations: from studying fundamental high energy plasma physics processes which operate throughout the Universe, such as adiabatic charged particle acceleration and nonlinear wave-particle interactions, to exploiting the astrobiological consequences of energetic particle radiation. The in-situ exploration of the uninviting environment of Jupiter’s radiation belts presents us with many challenges in mission design, science planning, instrumentation, and technology. We address these challenges by reviewing the different options that exist for direct and indirect observations of this unique system. We stress the need for new instruments, the value of synergistic Earth and Jupiter-based remote sensing and in-situ investigations, and the vital importance of multi-spacecraft in-situ measurements. While simultaneous, multi-point in-situ observations have long become the standard for exploring electromagnetic interactions in the inner Solar System, they have never taken place at Jupiter or any strongly magnetized planet besides Earth. We conclude that a dedicated multi-spacecraft mission to Jupiter is an essential and obvious way forward for exploring the planet’s radiation belts. Besides guaranteeing numerous discoveries and huge leaps in our understanding of radiation belt systems, such a mission would also enable us to view Jupiter, its extended magnetosphere, moons, and rings under new light, with great benefits for space, planetary, and astrophysical sciences. For all these reasons, in-situ investigations of Jupiter’s radiation belts deserve to be given a high priority in the future exploration of our Solar System. This article is based on a White Paper submitted in response to the European Space Agency’s call for science themes for its Voyage 2050 programme.
Extremal lifetimes of persistent cycles
Authors: Chenavier Nicolas , Hirsch Christian 
Published: October 2021

AbstractPersistent homology captures the appearances and disappearances of topological features such as loops and cavities when growing disks centered at a Poisson point process. We study extreme values for the lifetimes of features dying in bounded components and with birth resp. death time bounded away from the threshold for continuum percolation and the coexistence region. First, we describe the scaling of the minimal lifetimes for general feature dimensions, and of the maximal lifetimes for cavities in the Čech filtration. Then, we proceed to a more refined analysis and establish Poisson approximation for large lifetimes of cavities and for small lifetimes of loops. Finally, we also study the scaling of minimal lifetimes in the Vietoris-Rips setting and point to a surprising difference to the Čech filtration.
Upstream migration of anadromous and potamodromous brown trout: patterns and triggers in a 25-year overview
Authors: García-Vega Ana , Fuentes-Pérez Juan Francisco , Leunda Urretabizkaia Pedro M. , Ardaiz Ganuza José , Sanz-Ronda Francisco Javier 
Published: October 2021

AbstractRiver fragmentation and alterations in flow and thermal regimes are the main stressors affecting migrating fish, which could be aggravated by climate change and increasing water demand. To assess these impacts and define mitigation measures, it is vital to understand fish movement patterns and the environmental variables affecting them. This study presents a long-term (1995–2019) analysis of upstream migration patterns of anadromous and potamodromous brown trout in the lower River Bidasoa (Spain). For this, captures in a monitoring station were analyzed using Survival Analysis and Random Forest techniques. Results showed that most upstream movements of potamodromous trout occurred in October–December, whereas in June–July for anadromous trout, although with differences regarding sex and size. Both, fish numbers and dates varied over time and were related to the environmental conditions, with different influence on each ecotype. The information provided from comparative studies can be used as a basis to develop adaptive management strategies to ensure freshwater species conservation. Moreover, studies in the southern distribution range can be crucial under climate warming scenarios, where species are expected to shift coldwards.
Heart Rate Variability in Children and Adolescents with Autism, ADHD and Co-occurring Autism and ADHD, During Passive and Active Experimental Conditions
Authors: Bellato Alessio , Arora Iti , Kochhar Puja , Ropar Danielle , Hollis Chris , Groom Madeleine J. 
Published: October 2021

AbstractDespite overlaps in clinical symptomatology, autism and ADHD may be associated with opposite autonomic arousal profiles which might partly explain altered cognitive and global functioning. We investigated autonomic arousal in 106 children/adolescents with autism, ADHD, co-occurring autism/ADHD, and neurotypical controls. Heart rate variability was recorded during resting-state, a ‘passive’ auditory oddball task and an ‘active’ response conflict task. Autistic children showed hyper-arousal during the active task, while those with ADHD showed hypo-arousal during resting-state and the passive task. Irrespective of diagnosis, children characterised by hyper-arousal showed more severe autistic symptomatology, increased anxiety and reduced global functioning than those displaying hypo-arousal, suggesting the importance of considering individual autonomic arousal profiles for differential diagnosis of autism/ADHD and when developing personalised interventions.
Robust Virus-Specific Adaptive Immunity in COVID-19 Patients with SARS-CoV-2 Δ382 Variant Infection
Authors: Fong Siew-Wai , Yeo Nicholas Kim-Wah , Chan Yi-Hao , Goh Yun Shan , Amrun Siti Naqiah , Ang Nicholas , Rajapakse Menaka Priyadharsani , Lum Josephine , Foo Shihui , Lee Cheryl Yi-Pin , Carissimo Guillaume , Chee Rhonda Sin-Ling , Torres-Ruesta Anthony , Tay Matthew Zirui , Chang Zi Wei , Poh Chek Meng , Young Barnaby Edward , Tambyah Paul A. , Kalimuddin Shirin , Leo Yee-Sin , Lye David C. , Lee Bernett , Biswas Subhra , Howland Shanshan Wu , Renia Laurent , Ng Lisa F. P. 
Published: October 2021

AbstractThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) that have become dominant as the pandemic progresses bear the ORF8 mutation together with multiple spike mutations. A 382-nucleotide deletion (Δ382) in the ORF7b and ORF8 regions has been associated with milder disease phenotype and less systemic inflammation in COVID-19 patients. However, its impact on host immunity against SARS-CoV-2 remains undefined. Here, RNA-sequencing was performed to elucidate whole blood transcriptomic profiles and identify contrasting immune signatures between patients infected with either wildtype or Δ382 SARS-CoV-2 variant. Interestingly, the immune landscape of Δ382 SARS-CoV-2 infected patients featured an increased adaptive immune response, evidenced by enrichment of genes related to T cell functionality, a more robust SARS-CoV-2-specific T cell immunity, as well as a more rapid antibody response. At the molecular level, eukaryotic initiation factor 2 signaling was found to be upregulated in patients bearing Δ382, and its associated genes were correlated with systemic levels of T cell-associated and pro-inflammatory cytokines. This study provides more in-depth insight into the host–pathogen interactions of ORF8 with great promise as a therapeutic target to combat SARS-CoV-2 infection.
Biomarkers of DNA Damage Response Enable Flow Cytometry-Based Diagnostic to Identify Inborn DNA Repair Defects in Primary Immunodeficiencies
Authors: Felgentreff Kerstin , Baumann Ulrich , Klemann Christian , Schuetz Catharina , Viemann Dorothee , Wetzke Martin , Pannicke Ulrich , von Hardenberg Sandra , Auber Bernd , Debatin Klaus-Michael , Jacobsen Eva-Maria , Hoenig Manfred , Schulz Ansgar , Schwarz Klaus 
Published: October 2021

AbstractDNA damage is a constant event in every cell caused by exogenous factors such as ultraviolet and ionizing radiation (UVR/IR) and intercalating drugs, or endogenous metabolic and replicative stress. Proteins of the DNA damage response (DDR) network sense DNA lesions and induce cell cycle arrest, DNA repair, and apoptosis. Genetic defects of DDR or DNA repair proteins can be associated with immunodeficiency, bone marrow failure syndromes, and cancer susceptibility. Although various diagnostic tools are available to evaluate DNA damage, their quality to identify DNA repair deficiencies differs enormously and depends on affected pathways. In this study, we investigated the DDR biomarkers γH2AX (Ser139), p-ATM (Ser1981), and p-CHK2 (Thr68) using flow cytometry on peripheral blood cells obtained from patients with combined immunodeficiencies due to non-homologous end-joining (NHEJ) defects and ataxia telangiectasia (AT) in response to low-dose IR. Significantly reduced induction of all three markers was observed in AT patients compared to controls. However, delayed downregulation of γH2AX was found in patients with NHEJ defects. In contrast to previous reports of DDR in cellular models, these biomarkers were not sensitive enough to identify ARTEMIS deficiency with sufficient reliability. In summary, DDR biomarkers are suitable for diagnosing NHEJ defects and AT, which can be useful in neonates with abnormal TREC levels (T cell receptor excision circles) identified by newborn screening. We conclude that DDR biomarkers have benefits and some limitations depending on the underlying DNA repair deficiency.
The role of GTPase-activating protein ARHGAP26 in human cancers
Authors: Zhang Lingye , Zhou Anni , Zhu Shengtao , Min Li , Liu Si , Li Peng , Zhang Shutian 
Published: October 2021

AbstractRho GTPases are molecular switches that play an important role in regulating the behavior of a variety of tumor cells. RhoA GTPase-activating protein 26 (ARHGAP26) is a GTPase-activating protein and inhibits the activity of Rho GTPases by promoting the hydrolytic ability of Rho GTPases. It also affects tumorigenesis and progression of various tumors through several methods, including formation of abnormal fusion genes and circular RNA. This review summarizes the biological functions and molecular mechanisms of ARHGAP26 in different tumors, proposes the potential clinical value of ARHGAP26 in cancer treatment, and discusses current issues that need to be addressed.
Listening to vaccine refusers
Authors: Kärki Kaisa 
Published: October 2021

AbstractIn bioethics vaccine refusal is often discussed as an instance of free riding on the herd immunity of an infectious disease. However, the social science of vaccine refusal suggests that the reasoning behind refusal to vaccinate more often stems from previous negative experiences in healthcare practice as well as deeply felt distrust of healthcare institutions. Moreover, vaccine refusal often acts like an exit mechanism. Whilst free riding is often met with sanctions, exit, according to Albert Hirschman’s theory of exit and voice is most efficiently met by addressing concerns and increasing the quality and number of feedback channels. If the legitimate grievances responsible for vaccine refusal are not heard or addressed by healthcare policy, further polarization of attitudes to vaccines is likely to ensue. Thus, there is a need in the bioethics of vaccine refusal to understand the diverse ethical questions of this inflammable issue in addition to those of individual responsibility to vaccinate.
The effects of hyperuricemia on endothelial cells are mediated via GLUT9 and the JAK2/STAT3 pathway
Authors: Nie Qian , Liu Miaomiao , Zhang Zhimei , Zhang Xuemei , Wang Chao , Song Guangyao 
Published: October 2021

Abstract
Background
Uric acid (UA) transporters mediate the uptake and outflow of UA, and are greatly involved in the control of UA concentrations. Glucose transporter 9 (GLUT9), one of the UA transporters, has been confirmed to be expressed in human umbilical vein endothelial cells (HUVECs). This study aimed to characterize GLUT9’s effect on intracellular UA accumulation in HUVECs in a high-UA environment and to explore the mechanism of cellular dysfunction.

Methods and results
HUVECs were treated with UA to establish a model of cellular dysfunction. Then, UA uptake, GLUT9 expression and endothelial nitric oxide synthase (eNOS) and reactive oxygen species (ROS) amounts were measured. UA uptake was concentration- and time-dependent, and UA treatment significantly reduced nitric oxide (NO) levels and eNOS activity. UA also upregulated pro-inflammatory molecules and GLUT9, and increased intracellular ROS amounts in HUVECs. GLUT9 knockdown reduced UA uptake and ROS content, but antioxidant treatment did not reduce GLUT9 expression. To assess the function of JAK2/STAT3 signaling, HUVECs were treated with UA, and the phosphorylation levels of JAK2, STAT3, IL-6 and SOCS3 were increased by a high concentration of UA. In addition, GLUT9 knockdown reduced the phosphorylation of JAK2/STAT3 intermediates and increased p-eNOS amounts.

Conclusions
GLUT9 mediated the effects of high UA levels on HUVECs by increasing the cellular uptake of UA, activating JAK2/STAT3 signaling, and reduced the production of active eNOS and NO in HUVECs.
Independent Retailer Restocking Choices in Urban Goods Movement and Interaction Effects with Traditional Markets
Authors: Nugroho Taufiq Suryo , Balijepalli Chandra , Whiteing Anthony 
Published: October 2021

AbstractTraditional markets play a key role in local supply chains in many countries, often influencing retailer decisions due to their inherent attractiveness. In contrast to restocking choices for retailers as part of large chains, choices of independent retailers driven by local traditional markets have not been widely researched and are not well understood. This paper analyses the factors influencing independent retailer restocking choices and investigates the interplay between the presence of traditional markets and retailer choices. Bandung city in Indonesia is chosen for the study where independent retailers are prevalent, and where a number of traditional markets are thriving. A retrospective questionnaire was used to capture independent retailer restocking behaviour and generation models were calibrated to arrive at the trip propensity. Discrete choice models were estimated to explain the retailer preferences for supplier location and transport service choice. Results indicate that trips generated by independent retailers are explained by the presence of traditional markets and retailers’ vehicle ownership, in addition to the standard variables such as number of persons employed, weekly goods demand and average shipment weight. As for restocking location choice, retailers are more likely to choose suppliers within a traditional market where the number of wholesaler units is larger. Furthermore, the choice of traditional markets has a positive influence on whether retailers choose to use their own vehicle to restock their shops.
Phenomenological psychology and qualitative research
Authors: Englander Magnus , Morley James 
Published: October 2021

AbstractThis article presents the tradition of phenomenologically founded psychological research that was originally initiated by Amedeo Giorgi. This data analysis method is inseparable from the broader project of establishing an autonomous phenomenologically based human scientific psychology. After recounting the history of the method from the 1960’s to the present, we explain the rationale for why we view data collection as a process that should be adaptable to the unique mode of appearance of each particular phenomenon being researched. The substance of the article is then devoted to a detailed outline of the method’s whole-part-whole procedure of data analysis. We then offer a sample analysis of a brief description of an ordinary daydream. This is an anxiety daydream in response to the recent Covid-19 pandemic. We present this daydream analysis in full to show the concrete hands-on 5 step process through which the researcher explicated the participants’ expressions from the particular to the general. From this brief sample analysis, the researcher offers a first-person reflection on the data analysis process to offer the reader an introduction to the diacritical nature of phenomenological psychological elucidation.