bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Occurrence Timeline of Steroid-induced Ocular Hypertension and Cataract in Children With Systemic Autoimmune Diseases
Authors: Yan Honggai , Tan Xiaohua , Yu Jifeng , Liang Tianwei , Shi Wei , Li Li , Peng Chunxia 
Published: August 2021

Abstract
Purpose Steroid-induced ocular hypertension (SIOH) and cataract can result in visual loss. This study evaluated the timetable of SIOH and steroid-induced posterior subcapsular cataract (SI-PSC) occurrences in children with systemic autoimmune diseases (SAD) undergoing long-term systemic corticosteroid treatment.Methods Thirty-seven children with SAD treated with long-term oral corticosteroids were enrolled in this study. Intraocular pressure (IOP), SI-PSC occurrences, visual field and peripapillary retinal nerve fibre layer (pRNFL) thicknesses were recorded every 3 months for at least 6 months.Results Of the 37 children, with average age 11.0±2.9 years, 22 patients (59.5%) had SIOH, 2 progressed as glaucoma at the 18-month and 3-year follow-up respectively and 12 (32.4%) patients had SI-PSC. Among patients with SIOH, 45.5% (10/22) of them had SI-PSC occurrences and among patients with normal IOP, 13.3% (2/15) of them had SI-PSC. Seventeen patients participated in a longitudinal study with a follow-up period of at least 18 months. The incidence of SIOH started at 1 month (52%, 9/17) and gradually increased to its peak value (70.6%,12/17) at 6 months, then decreased to 35.3% (6/17). SI-PSC onset started at 6 months (17.6%, 3/17), and its occurrence increased to 35.3% (6/17) at 12 months and reached to 41.2% (7/17) at 18 months. The pRNFL was thicker in the children with SIOH than the healthy controls (p = 0.01).Conclusion SIOH and SI-PSC are common coexistent complications in children with long-term corticosteroids treatment and the occurrence time is during the first month and 6 months, respectively. Patients with SIOH have a higher probability of cataract.
Long-segment Fixation VS Short-segment Fixation Combined With Kyphoplasty for Osteoporotic Thoracolumbar Burst Fracture
Authors: Lai Oujie , Zhang Xinliang , Hu Yong , Sun Xiaoyang , Zhu Binke , Dong Weixin , Yuan Zhenshan 
Published: August 2021

Abstract
BackgroundTo compare clinical and radiological results of long-segment fixation (LF) and six-screw short-segment fixation combined with kyphoplasty (SSFK) for osteoporotic thoracolumbar burst fracture (OTBF). Methods Forty patients affected by OTBF with mean age of 61.85 were included in this study. The mean follow-up period was 13.63 months. Twenty-four patients were treated by SSFK, and 16 patients were treated by LF. Clinical outcomes, radiological parameters and complications were assessed and compared. ResultsThe mean operative time and blood loss were 89.71±7.62min and 143.75±42.51ml for SFK group, respectively; 111.69±12.25min (P<0.01) and 259.38±49.05 ml (P<0.01) for LF group, respectively. The two groups were similar in terms of preoperative radiological and clinical results. Compared with preoperative values, both groups achieved significant improvement in terms of VAS, ODI, Cobb angle and anterior vertebral body height (AVH) ratio at final follow-up. However, during the follow-up period, the loss of Cobb angle and AVH ratio were significant different between immediately postoperative and final follow-up evaluations for both groups. Five cases (20.83%) of asymptomatic cement leakage were observed in SSFK group. One case of implant failure and two cases of adjacent or non-adjacent vertebral fractures were observed in LF group. ConclusionsFor the treatment of OTBF, SSFK shows similar clinical and radiological results as LF. Comparatively, SSFK is less invasive and can preserve more motion segments, which is a more valuable surgical option in selected elderly patients.
Characterization of Agricultural Soils of Two Shared Lands of the Irrigation District 028, in Tulancingo, Hidalgo. Mexico
Authors: Romero-Oliva Oscar , Prieto-Méndez Judith , GARCIA FRANCISCO PRIETO , Aquino-Torres Eliazar , Otazo-Sánchez Elena 
Published: August 2021

Abstract
The authors have requested that this preprint be removed from Research Square.
Reappraisal of the sub species hypothesis for Gangetic dolphins based on mitochondrial genomics
Authors: Jadhav Chandrakant , Khedkar Gulab , Khedkar CD , Prakash Bharathi , Pillai Sanil 
Published: August 2021

Abstract
The Gangetic dolphin, P. gangetica, is one of the oldest known creatures, and its taxonomic status has been debated for over two centuries with no agreement. The clarification of the systematic relationships of Platanista taxa has been listed as among the highest priority for all cetaceans. Of the several taxonomic schemes proposed, all have been very limited and do not provide sufficient weight of evidence to defend any taxonomic classification. Consequently, to resolve this case, a new mitochondrial genome record for P. gangetica gangetica was created for quantitative evaluation of the Ganges and Indus River dolphin populations to estimate species boundaries. This has aided in the resolution of the taxonomic status of the Gangetic dolphin, P. gangetica by showing that the subspecies P. gangetica gangetica and P. gangetica minor are indistinguishable based on the molecular differences and do not follow the standards for molecular species boundaries. Also geographic historical reviews show that these two populations were one during the Miocene era, and that segregation occurred during the geosyncline effect of the Bay of Bengal. However, with the present set of evidences, we propose to abandon the subspecies hypothesis for these P. gangetica taxa.
Is there a link between lung parenchyma lesions , BMI , CRP , D-dimer and acute pulmonary embolism in patients infected with COVID-19 ?
Authors: Hamadé Amer , Jambert Lucas , Tousch Jonathan , Feuerstein Philippe , Hammas Karima , Degoul Samuel , Bensalah Naouel , Michel Pierre , Lehn-Hogg Michèle , Obringer Golnaz , Buschenrieder Nathalie , Nusbaum Philippe , Barakat Nayrouz , Talbot Marjolaine , Stephan Dominique , Woehl Bastien 
Published: August 2021

Introduction:
ince the outbreak of the COVID-19 pandemic , increasing suggests that
infected patients present a high incidence of venous thromboembolic events (VTE).
The main objective of this retrospective study was to evaluate the prevalence of acute
pulmonary embolism (PE) on pulmonary computer tomography angiograms (CTPA) in
patients classified as COVID-19 infection. The second objective was to determine if there is a
link between D-dimer levels, serum C-reactive protein (CRP ), body mass index
(BMI) , the lung parenchyma lesions (LPL) and acute pulmonary embolism (PE) in these
patients.

Material and Methods:
120 patients with mean age 65 ±14.5 years infected with COVID- 19
underwent in our institution a CTPA for suspected PE .Thirty four were in intensive care
units (ICU). A COVID-19 diagnosis was made by transcriptase polymerase chain reaction
by means of nasopharyngeal swab or by chest CT images. Demographics and co-morbidities
characteristics were collected . Laboratory parameters were automatically extracted from
our heath information system. When PE was suspected a CTPA were acquired after injection
of high concentration iodine contrast media .The criterion of suspected PE were based on
the clinical respiratory deterioration , with an increased need for oxygen. A venous duplex
ultrasound (DU) test of lower limbs was performed on admission.

Results:
CTPA showed 24 acute PE (20%) , of which 11 primary and 13 associated with
deep venous thrombosis diagnosed on DU .Eleven of the 24 (45.8 %)had PE
despite preventive and therapeutic anticoagulation with low molecular weight heparin with
Enoxaparin (7 with preventive anticoagulation and 4 had therapeutic dose), of them 8
(72.7%) with risk factors for VTE .Acute PE was not significantly associated with CRP and LPL.
However , we found a significant association between acute PE and BMI (mean 32.41±5.90
versus 27.1± 5.2 kg/m2, p 0.0007) or D-dimer Levels (mean 6040±5068 versus
3396.7±5361.5 ng/ml ,p <0.0001).

Conclusions:
Hospitalized patients infected with COVID-19 in conventional units or ICU
have a high frequency of PE justifying preventive anticoagulation. For those who have a risk
factors for VTE a therapeutic anticoagulation may be indicated.
Pharmacological Activities and Therapeutic Potential of Kaempferitrin in Medicine for the Treatment of Human Disorders: A Review of Medicinal Importance and Health Benefits
Authors: Patel Dinesh Kumar 
Published: August 2021

Background:
Herbal drugs and their derived phytochemicals are valuable for human beings
as a source of a vital component of food material and drugs. Flavonoids are naturally occurring
phytochemicals produced in plants through metabolisms, and they have anti-hyperlipidemia,
anti-inflammatory, anti-oxidant and anti-apoptotic activity. Flavonoids have been identified in
fruits, nuts, vegetables, seeds, stems, flowers, and tea. Kaempferol is a natural flavonoidal compound
present in edible plants such as apples, broccoli, strawberries, beans, grapefruit, propolis,
and medicinal plants such as Aloe vera, Ginkgo biloba, Rosmarinus officinalis, Crocus sativus L.,
Hypericum perforatum L. Kaempferol have anti-oxidant, anti-inflammatory, anti-apoptotic, proapoptotic,
cardio-protective and anti-cancer activities.

Methods:
Glycosides of kaempferol such as kaempferitrin, also called kaempferol 3,7-dirhamnoside
are known to be more abundant than their flavonoid monomers in plants. Various literature
databases have been searched to collect all the scientific information of kaempferitrin in the present
investigation and analyzed in order to know the therapeutic benefit and biological potential of
kaempferitrin. Moreover, all the information has been presented here in two broad sections, i.e.,
pharmacological and analytical.

Results:
From the analysis of all the collected and presented information, it was found that
kaempferitrin has potent insulin-mimetic potential and could be used for the treatment of diabetes
and related complications. However, it has also shown anti-oxidant, anti-inflammatory, anti-convulsant,
anti-osteoporotic, anti-depressant, anthelmintic, immunostimulatory, and natriuretic properties
and inhibits cell proliferation and apoptosis. Kaempferitrin also improves the meat quality of
broiler chickens.

Conclusions:
The presented information in this work will be valuable to justify the biological importance
and therapeutic potential of kaempferitrin in the scientific field.
La Colección Entomológica del Instituto-Fundación Miguel Lillo, Tucumán, Argentina
Authors: Córdoba Silvia Patricia , Pérez Emilia Constanza 
Published: August 2021

La Colección Entomológica del Instituto-Fundación Miguel Lillo (IFML) conserva y custodia el material allí depositado con el fin de facilitar su estudio por parte de toda la comunidad científica actual y futura. Está constituida por la colección entomológica conservada en seco y en alcohol, en dos salones equipados para el resguardo y conservación del material. Atesora 6,500,000 ejemplares de los órdenes Blattodea, Coleoptera, Collembola, Dermaptera, Diptera, Embioptera, Ephemeroptera, Hemiptera, Hymenoptera, Isoptera, Mecoptera, Megaloptera, Lepidoptera, Neuroptera, Odonata, Orthoptera, Phthiraptera, Plecoptera, Psocoptera, Thysanoptera, Trichoptera y Zygentoma. La colección entomológica del I-FML preserva 11,216 ejemplares de la serie tipo, asignados a 2,185 especies, principalmente del Neotrópico, además de ejemplares de diversas partes del mundo. Es un referente de la biodiversidad de insectos neotropicales y ha sido fundada en el año 1944 a partir del material colectado por el Dr. Miguel Lillo. El objetivo del presente trabajo es dar a conocer de manera general, la organización, características, situación actual y perspectivas futuras de la colección entomológica del I-FML. Dada su importancia, tanto para la comunidad científica como para la sociedad en general, es necesario garantizar la conservación de los ejemplares allí depositados.
Management and Treatment of Patients With Obstructive Sleep Apnea Using an Intelligent Monitoring System Based on Machine Learning Aiming to Improve Continuous Positive Airway Pressure Treatment Compliance: Randomized Controlled Trial
Authors: Turino Cecilia , Benítez Ivan D , Rafael-Palou Xavier , Mayoral Ana , Lopera Alejandro , Pascual Lydia , Vaca Rafaela , Cortijo Anunciación , Moncusí-Moix Anna , Dalmases Mireia , Vargiu Eloisa , Blanco Jordi , Barbé Ferran , de Batlle Jordi 
Published: August 2021

Background
Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnea (OSA), but treatment compliance is often unsatisfactory.

Objective
The aim of this study was to assess the effectiveness and cost-effectiveness of an intelligent monitoring system for improving CPAP compliance.

Methods
This is a prospective, open label, parallel, randomized controlled trial including 60 newly diagnosed patients with OSA requiring CPAP (Apnea–Hypopnea Index [AHI] >15) from Lleida, Spain. Participants were randomized (1:1) to standard management or the MiSAOS intelligent monitoring system, involving (1) early compliance detection, thus providing measures of patient’s CPAP compliance from the very first days of usage; (2) machine learning–based prediction of midterm future CPAP compliance; and (3) rule-based recommendations for the patient (app) and care team. Clinical and anthropometric variables, daytime sleepiness, and quality of life were recorded at baseline and after 6 months, together with patient’s compliance, satisfaction, and health care costs.

Results
Randomized patients had a mean age of 57 (SD 11) years, mean AHI of 50 (SD 27), and 13% (8/60) were women. Patients in the intervention arm had a mean (95% CI) of 1.14 (0.04-2.23) hours/day higher adjusted CPAP compliance than controls (P=.047). Patients’ satisfaction was excellent in both arms, and up to 88% (15/17) of intervention patients reported willingness to keep using the MiSAOS app in the future. No significant differences were found in costs (control: mean €90.2 (SD 53.14) (US $105.76 [SD 62.31]); intervention: mean €96.2 (SD 62.13) (US $112.70 [SD 72.85]); P=.70; €1=US $1.17 was considered throughout). Overall costs combined with results on compliance demonstrated cost-effectiveness in a bootstrap-based simulation analysis.

Conclusions
A machine learning–based intelligent monitoring system increased daily compliance, reported excellent patient satisfaction similar to that reported in usual care, and did not incur in a substantial increase in costs, thus proving cost-effectiveness. This study supports the implementation of intelligent eHealth frameworks for the management of patients with CPAP-treated OSA and confirms the value of patients’ empowerment in the management of chronic diseases.

Trial Registration
ClinicalTrials.gov NCT03116958; https://clinicaltrials.gov/ct2/show/NCT03116958
Understanding the Relationship Between Official and Social Information About Infectious Disease: Experimental Analysis
Authors: Assaf Elias , Bond Robert M , Cranmer Skyler J , Kaizar Eloise E , Ratliff Santoro Lauren , Shikano Susumu , Sivakoff David J 
Published: August 2021

Background
Communicating official public health information about infectious diseases is complicated by the fact that individuals receive much of their information from their social contacts, either via interpersonal interaction or social media, which can be prone to bias and misconception.

Objective
This study aims to evaluate the effect of public health campaigns and the effect of socially communicated health information on learning about diseases simultaneously. Although extant literature addresses the effect of one source of information (official or social) or the other, it has not addressed the simultaneous interaction of official information (OI) and social information (SI) in an experimental setting.

Methods
We used a series of experiments that exposed participants to both OI and structured SI about the symptoms and spread of hepatitis C over a series of 10 rounds of computer-based interactions. Participants were randomly assigned to receive a high, low, or control intensity of OI and to receive accurate or inaccurate SI about the disease.

Results
A total of 195 participants consented to participate in the study. Of these respondents, 186 had complete responses across all ten experimental rounds, which corresponds to a 4.6% (9/195) nonresponse rate. The OI high intensity treatment increases learning over the control condition for all symptom and contagion questions when individuals have lower levels of baseline knowledge (all P values ≤.04). The accurate SI condition increased learning across experimental rounds over the inaccurate condition (all P values ≤.01). We find limited evidence of an interaction between official and SI about infectious diseases.

Conclusions
This project demonstrates that exposure to official public health information increases individuals’ knowledge of the spread and symptoms of a disease. Socially shared information also facilitates the learning of accurate and inaccurate information, though to a lesser extent than exposure to OI. Although the effect of OI persists, preliminary results suggest that it can be degraded by persistent contradictory SI over time.
Automated Screening for Social Anxiety, Generalized Anxiety, and Depression From Objective Smartphone-Collected Data: Cross-sectional Study
Authors: Di Matteo Daniel , Fotinos Kathryn , Lokuge Sachinthya , Mason Geneva , Sternat Tia , Katzman Martin A , Rose Jonathan 
Published: August 2021

Background
The lack of access to mental health care could be addressed, in part, through the development of automated screening technologies for detecting the most common mental health disorders without the direct involvement of clinicians. Objective smartphone-collected data may contain sufficient information about individuals’ behaviors to infer their mental states and therefore screen for anxiety disorders and depression.

Objective
The objective of this study is to compare how a single set of recognized and novel features, extracted from smartphone-collected data, can be used for predicting generalized anxiety disorder (GAD), social anxiety disorder (SAD), and depression.

Methods
An Android app was designed, together with a centralized server system, to collect periodic measurements of objective smartphone data. The types of data included samples of ambient audio, GPS location, screen state, and light sensor data. Subjects were recruited into a 2-week observational study in which the app was run on their personal smartphones. The subjects also completed self-report severity measures of SAD, GAD, and depression. The participants were 112 Canadian adults from a nonclinical population. High-level features were extracted from the data of 84 participants, and predictive models of SAD, GAD, and depression were built and evaluated.

Results
Models of SAD and depression achieved a significantly greater screening accuracy than uninformative models (area under the receiver operating characteristic means of 0.64, SD 0.13 and 0.72, SD 0.12, respectively), whereas models of GAD failed to be predictive. Investigation of the model coefficients revealed key features that were predictive of SAD and depression.

Conclusions
We demonstrate the ability of a common set of features to act as predictors in the models of both SAD and depression. This suggests that the types of behaviors that can be inferred from smartphone-collected data are broad indicators of mental health, which can be used to study, assess, and track psychopathology simultaneously across multiple disorders and diagnostic boundaries.
Logistics Workers Are a Key Factor for SARS-CoV-2 Spread in Brazilian Small Towns: Case-Control Study
Authors: Bernardes-Souza Breno , Júnior Saulo Ricardo Costa , Santos Carolina Ali , Neto Raimundo Marques Do Nascimento , Bottega Fernando De Carvalho , Godoy Daiana Carolina , Freitas Bruno Lourençoni , Silva Daniela Leite Garcia , Brinker Titus Josef , Nascimento Raiza Aranha , Tupinambás Unaí , Reis Alexandre Barbosa , Coura-Vital Wendel 
Published: August 2021

Background
Data on how SARS-CoV-2 enters and spreads in a population are essential for guiding public policies.

Objective
This study seeks to understand the transmission dynamics of SARS-CoV-2 in small Brazilian towns during the early phase of the epidemic and to identify core groups that can serve as the initial source of infection as well as factors associated with a higher risk of COVID-19.

Methods
Two population-based seroprevalence studies, one household survey, and a case-control study were conducted in two small towns in southeastern Brazil between May and June 2020. In the population-based studies, 400 people were evaluated in each town; there were 40 homes in the household survey, and 95 cases and 393 controls in the case-control study. SARS-CoV-2 serology testing was performed on participants, and a questionnaire was applied. Prevalence, household secondary infection rate, and factors associated with infection were assessed. Odds ratios (ORs) were calculated by logistic regression. Logistics worker was defined as an individual with an occupation focused on the transportation of people or goods and whose job involves traveling outside the town of residence at least once a week.

Results
Higher seroprevalence of SARS-CoV-2 was observed in the town with a greater proportion of logistics workers. The secondary household infection rate was 49.1% (55/112), and it was observed that in most households (28/40, 70%) the index case was a logistics worker. The case-control study revealed that being a logistics worker (OR 18.0, 95% CI 8.4-38.7) or living with one (OR 6.9, 95% CI 3.3-14.5) increases the risk of infection. In addition, having close contact with a confirmed case (OR 13.4, 95% CI 6.6-27.3) and living with more than four people (OR 2.7, 95% CI 1.1-7.1) were also risk factors.

Conclusions
Our study shows a strong association between logistics workers and the risk of SARS-CoV-2 infection and highlights the key role of these workers in the viral spread in small towns. These findings indicate the need to focus on this population to determine COVID-19 prevention and control strategies, including vaccination and sentinel genomic surveillance.
Importancia del diálogo intercultural en el desarrollo turístico en comunidades indígenas totonacas
Authors: Ortíz Rodríguez Ma. Teresa Tonantzin , Sandoval Quintero Mayra Antonieta 
Published: August 2021

<p>A partir de una postura crítica sobre los impactos del desarrollo turístico, tanto convencional como alternativo, es notoria su imposición como una medida emergente de mejora económica en los pueblos originarios. Este estudio tiene el objetivo de proporcionar una primera aproximación a las bases teóricas y metodológicas que sustentan la pertinencia del uso del denominado diálogo intercultural. El mé-<br /> todo empleado para el presente artículo considera al diálogo como indicador para minimizar los efectos socioculturales de una propuesta turística. Se toma como eje fundamental el papel protagónico de los indígenas para decidir sobre el aprovechamiento de sus recursos como atractivos turísticos (patrimonio biocultural), en este caso, de los totonacos de Lipuntahuaca, municipio de Huehuetla, Puebla, a partir de sus propias formas culturales, asumiendo los riesgos que ello conlleva ante una economía de mercado. Los hallazgos dan pauta a la discusión del turismo comunitario de tipo vivencial antepuesto, y a la vez complementado, por la cosmovisión y los saberes tradicionales.</p><div> </div>