bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Effectiveness of Fecal Immunochemical Tests versus Flexible Sigmoidoscopy for Colorectal Cancer Screening: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Authors: Mutneja Hemant , Agrawal Rohit , Bhurwal Abhishek , Arora Shilpa , Go Andrew , Attar Bashar 
Published: May 2021

Background and Aims: Fecal immunochemical tests (FITs) and flexible sigmoidoscopies are commonly used modalities for colorectal cancer (CRC) screening. We performed a systematic review and meta-analysis to compare the effectiveness of FIT and sigmoidoscopy in CRC screening.
Methods: PRISMA statement and Cochrane guidelines were followed for this review. Digital dissertation databases were searched from inception till December 1st 2020 and randomized clinical trials comparing the detection rates of CRC for FIT and sigmoidoscopy were included. Outcomes for analysis included participation rates and detection rates of CRC, advanced adenomas and advanced colorectal neoplasia for both screening modalities.
Results: Five randomized clinical trials with a total of 261,755 patients were included for the analysis. The participation rate for FIT was significantly higher compared to flexible sigmoidoscopy (OR 2.11, 95% CI 1.29-3.44, p=0.003). In intention-to-screen analysis, the detection rate for advanced colorectal neoplasia was significantly lower with FIT (OR 0.62, 95% CI 0.45-0.84, p=0.002) as compared to flexible sigmoidoscopy but not statistically different for CRC (OR 1.15, 95% CI 0.65-2.02, p=0.63).
Conclusion: Despite lower participation amongst patients, CRC screening with flexible sigmoidoscopy leads to higher detection of advanced colorectal neoplasia, when compared to a single round of fecal immunochemical testing.
Romanian Guidelines for Nonpharmacological Therapy of IBS
Authors: Dumitrascu Dan L. , Baban Adriana , Bancila Ion , Barboi Oana , Bataga Simona , Chira Alexandra , Chirila Ioan , Cijevschi Prelipcean Cristina , Ciobanu Lidia , Cozma-Petrut Anamaria , David Liliana , Diculescu Mircea , Dobru Daniela , Dimitriu Anca , Dumitru Eugen , Fadgyas-Stanculete Mihaela , Gheorghe Cristian , Gilca-Blanariu Georgiana-Emmanuela , Goldis Adrian , Grad Simona , Macarie Melania , Marica-Sabo Cristina , Miere Doina , Nedelcu Laurentiu , Negovan Anca , Pojoga Cristina , Pop Andrei Vasile , Popa Stefan-Lucian , Porr Paul Juergen , Rusu Flaviu , Seicean Andrada , Sporea Ioan , Stroie Tudor , Blaga-Surdea Teodora , Tocia Cristina , Trifan Anca , Brisc Ciprian , Drug Vasile 
Published: May 2021

Background and Aims: The nonpharmacological therapy in irritable bowel syndrome (IBS) is expanding rapidly. Practitioners and medical educators need to be aware of progress and changes in knowledge of this topic. The Romanian Society of Neurogastroenterology aimed to create guidelines based on best evidence on the use of nonpharmacological therapy in IBS.
Methods: A group of experts was constituted. This was divided in eleven subgroups dedicated to eleven categories of nonpharmacological therapy. The subgroups searched the literature and formulated statements and recommendations. These were submitted to vote in order to obtain consensus.
Results: The outcome of this activity is represented by the guidelines of the Romanian Society of Neurogastroenterology, presented in this paper. The recommendations are seen as complementary to the pharmacological therapy and are not intended to recommend avoiding pharmacological drugs.
Conclusions: These guidelines were elaborated by a Delphi process and represent a useful tool for physicians managing patients with IBS.
Pengelolaan website sebagai Media Informasi Publik
Authors: Himaturipa Rina , Maarif Abdul Azis , Abidin Yusuf Zaenal 
Published: May 2021

Tujuan dari penelitian ini adalah untuk mengetahui proses pengelolaan dimulai dari pencarian data dan fakta, perencanaan, pengaplikasian program, serta tahap evaluasi. Proses ini merupakan rangkaian dari pengaplikasian konsep four step public relations yang dijalankan oleh humas Kantor Wilayah Kementrian Agama Provinsi Jawa Barat, yaitu tahap fact finding, planning and programming, taking actions and communications, and evaluations. Penelitian ini menggunakan paradigma konstruktivisme , pendekatan kualitatif dan metode studi kasus, mengenai suatu lembaga atau organisasi dengan berupa fenomena yang ada dan terjadi nyata disuatu lembaga atau organisasi. Hasil dari penelitian ini menerangkan bahwa proses pengelolaan website menghasilkan data yang terbagi kedalam dua bagian yaitu fakta primer dan sekunder , setelah data didapatkan selanjutnya perencanaan program aplikasi yang memudahkan publik, lalu pengaplikasian program aplikasi seperti halnya E-MTQ, SIMKAH, dan lain-lain, tahap akhir yaitu evaluasi yang dilakukan seperti Rapat Koordinasi dengan Pemerintah Provinsi dan Kab/Kota.
Kata Kunci : Pengelolaan; Humas; Website

The purpose of this research is to find out the management process, Fact Finding, Planning and programming, Taking Actions and communications, and evaluation stages. This process is a series of applications of the four-step public relations concept run by the PR of the Regional Office of the Ministry of Religion of West Java Province. Researchers also use a case study approach that is about an institution or organization in the form of phenomena that exist and occur real in an institution or organization. The results of this study explain that the website management process produces data which is divided into two parts, namely primary and secondary facts, after the data is obtained then the planning of application programs that facilitate the public, then application of application programs such as E-MTQ, SIMKAH, and others, the final stage is an evaluation conducted such as a Coordination Meeting with the Provincial and District / City Governments.
Keywords: Management; PR; Website
Manajemen Humas Radio Rama 104.7FM Bandung dalam Meningkatkan Pemasang Iklan
Authors: Triadi Muhamad Sidik , Sanusi Irfan , Cholidah Lida Imelda 
Published: May 2021

ABSTRAK
Penulisan ini bertujuan untuk mengetahui manajemen humas radio Rama FM Bandung dalam meningkatkan pemasang iklan dari mulai tahapan perencanaan, pengorganisasian, pelaksanaan sampai dengan pengawasan, metode penelitian ini menggunakan metode kualitatif untuk mengetahui karakteristik dengan cara berinteraksi secara langsung dan mendalam mengenai sebuah program dan ringkasan yang digambarkan pada konteks di atas mendasari untuk menggali dan mendeskripsikan kegiatan-kegiatan yang dijalankan oleh radio Rama FM Bandung dalam meningkatkan pemasang iklan. Analisis penelitian ini menggunakan deskriptif kualittaif. Hasil penelitian menunjukan bahwa kegiatan manajemen humas radio Rama FM Bandung dalam meningkatkan pemasang iklan dimulai pada tahapan pertama yaitu perencanaan pembuatan proposal, inovasi program, pengemasan iklan dan penyampaian iklan. Tahapan kedua yaitu pengorganisasian dengan komunikasi, membentuk team, pertimbangan tugas, dan persetujuan dari pimpinan. Tahapan ketiga yaitu pelaksanaan sesuai tugas, presentasi, pelaksanaan tugas sesuai susunan, pelaksanaan kegiatan. Tahap keempat yaitu pengawasan koordinasi, kinerja team yang bertugas, program yang berlangsung, dan pengawasan proses sebagai bahan evaluasi.
Kata Kunci : Manajemen Humas; Meningkatkan; Pemasang Iklan.
ABSTRACT
This writing aims to determine radio public relations management Rama FM Bandung in increasing advertisers from the stages of planning, organizing, implementation to supervision, this research method uses a case study method to determine the characteristics by interacting directly and deeply about a case and summary illustrated in the above context underlying to explore and describe the activities carried out by radio Rama FM Bandung in improving advertisers. The analysis of this study uses descriptive qualitative. The results showed that the radio public relations management activities of Rama FM Bandung in increasing advertisers began in the first stage, namely the planning of making proposals, program innovation, packaging of advertisements and delivery of advertisements. The second stage is organizing with communication, forming teams, considering assignments, and approval from the leadership. The third stage is the implementation of tasks, presentations, implementation of tasks according to the arrangement, implementation of activities. The fourth stage is monitoring coordination, the performance of the team in charge, the ongoing program, and monitoring the process as an evaluation material.
Keywords : Management Public Relations; Improve; Advertiser.
Manajemen Krisis dalam Menangani Pipa Gas Meledak Tahun 2015
Authors: Syanizar Fahmi , Sanusi Irfan , Dulwahab Encep 
Published: May 2021

ABSTRAK
Tujuan penelitian ini adalah untuk menjelaskan tentang proses manajemen krisis dalam menangani pipa gas meledak tahun 2015 yang dilakukan oleh humas PT Star Energy Gheothermal Wayang Windu Bandung. Penelitian ini menggunakan paragdima kontruktivisme, metode kualitatif dan pendekatan studi kasus yang bertujuan untuk mengetahui proses manajemen krisis dalam menangani pipa gas meledak oleh humas PT.Star Energy Gheothermal Wayang windu Bandung. Hasil penelitian menunjukan bahwa manajemen krisis dalam menangani pipa gas meledak tahun 2015 oleh humas PT. Star Energy Gheothermal Wayang Windu Bandung tersebut dimulai dengan tahapan koordinasi penentuan masalah, observasi lokasi, ditemukannya masalah, analisis masalah, selanjutnya melakukan perencanaan dan pemprograman dengan tahapan membuat rencana, perencanaan target, koordinasi perencanaan, konfirmasi, lalu pelaksanaan dan pengkomunikasian didalamnya ada koordinasi pelaksanaan, pelaksanaan penanggulangan krisis, laporan kepada kantor pusat perusahaan, selanjutnya tahapan evaluasi yang dilakukan secar berkala terakhir peran humas kepada masyarakat untuk menyampaikan informasi terkait krisis yang sedang terjadi.
ABSTRACT
The purpose of this study was to explain the crisis management process in handling gas pipes exploding in 2015 by PT Star Energy Gheothermal Wayang Windu Bandung PR. This study uses the paradigm of constructivism, qualitative methods and a case study approach which aims to find out the process of crisis managementThe results of the study show that crisis management in handling gas pipes exploded in 2015 by public relations company with the coordination of problem determination, location observation, problem finding, problem analysis, then planning and programming with the stages of planning, target planning, coordinating planning, confirmation, then implementing and communicating in there implementation coordination, implementation of crisis response, report to the company's head office, then the evaluation phase is carried out in the last period of the public relations role to the community to convey information related to the crisis that is currently happening.
Proses Kegiatan Publikasi Program Pusat Pelayanan Terpadu Kesehatan Haji dan Umroh Melalui 4 Steps Public Relations
Authors: Yulianti Nurhasanah , Abidin Yusuf Zaenal , Darsono Dono 
Published: May 2021

Publikasi adalah kegiatan menyebarluaskan informasi kepada publik. Tujuan penelitian ini untuk mengetahui proses penemuan masalah/pencarian data dan fakta, perencanaan dan pemrograman, mengambil tindakan dan komunikasi, dan kegiatan evaluasi pada publikasi. Penelitian ini menggunakan konsep 4 Steps Public Relations dari Cutlip, Center and Broom. Landasan penelitian ini berpijak pada konsep 4 Steps Public Relations yang mengacu kepada publikasi dan Public Relations. Penelitian ini menggunakan pendekatan kualitatif, metode deskriptif kualitatif dan paradigma kontruktivisme, teknik pengumpulan data yang di lakukan dalam penelitian ini menggunakan wawancara dan observasi. Berdasarkan hasil penelitian diperoleh kesimpulan: pertama, Defining Public Relations Problem: Pengumpulan data travel, menentukan bahan publikasi, koordinasi, sponsorship, pengajuan proposal kegiatan. Kedua, Planning and Programming: Menentukan dan memahami tujuan dan target, planning tema dan desain grafis untuk publikasi. Ketiga, Taking Action and Communicating: Menentukan bentuk publikasi, penggunaan media dalam publikasi dan sasaran komunikasi. Keempat, Evaluations: Melihat respon masyarakat, melihat kunjungan publik P2TKHU, melakukan upaya peningkatan kualitas publikasi.
Publication is the activity of disseminating information to the public. The purpose of this research is to find out the process of finding problems/finding data and facts, planning and programming, taking action and communication, and evaluating activities in publications. This research uses the concept of 4 Steps Public Relations from Cutlip, Center and Broom. The basis of this research rests on the concept of 4 Steps Public Relations which refers to publications and Public Relations. This Research uses a qualitative approach, qualitative descriptive methods and constructivism paradigms, data collection techniques carried out in this research using interviews and observation. Based on the results of the research concluded: first, Defining Public Relations Problem: Collection of travel data, determine material for publication, coordination, sponsorship, submission of proposal activities. Second, Planning and Programming: Determine and understand objectives and targets, planning themes and graphic design for publication. Third, Taking Action and Communicating: Determine the form of publication, use of media in publications and communication goals. Fourth, Evaluations: Seeing the response of the community, seeing P2TKHU's public visit, making efforts to improve the quality of publications.
Dakwah dalam Pendekatan Konsep Ekologi
Authors: Fitriani Vina , Aliyudin Mukhlis 
Published: May 2021

ABSTRACT
The purpose of this research is to find out what is the background of ecological preaching messages, ecological da'wah activities and to determine the meaning of ecological preaching. The research method used is descriptive qualitative with a phenomenological theory approach. The results obtained explain that the background of ath-thaariq's ecological preaching message, first is the existence of agrarian conflict, second is the green revolution, third is the lack of knowledge and understanding of the community about the environment. Ecological da'wah activities carried out through the concept of planting, maintaining and utilizing the environment. The meaning of ecological da'wah can be viewed in terms of the underlying motive and basic goals expected of the Ath-Thaariq Islamic boarding school in carrying out its da'wah activities through an ecological approach. Da'wah in this ecological approach is very accepted, both by Ath-Thaariq students and the surrounding community.
Keywords: Da'wah; Ecology; Islamic Boarding School;
ABSTRAK
Tujuan penelitian ini untuk mengetahui apa yang melatarbelakangi pesan dakwah ekologis, aktivitas dakwah ekologis serta untuk mengetahui makna dakwah ekologis. Metode penelitian yang digunakan yaitu deskriptif kualitatif dengan pendekatan teori fenomenologi. Hasil penelitian yang diperoleh menjelaskan bahwa yang melatarbelakangi pesan dakwah ekologis ath-thaariq, pertama adanya konflik agraria, kedua adanya revolusi hijau, ketiga kurangnya pengetahuan dan pemahaman masyarakat mengenai lingkungan. Aktivitas dakwah ekologis yang dilakukan melalui konsep penanaman, pemeliharaan serta pemanfaatan lingkungan. Makna dakwah ekologis dapat ditinjau dari segi motive yang mendasari dan dasar tujuan yang diharapkan pesantren Ath-Thaariq dalam melakukan aktivitas dakwahnya melalui pendekatan ekologi. Dakwah dalam pendektan ekologi ini sangat diterima, baik itu oleh santri Ath-Thaariq maupun masyarakat sekitar.
Kata Kunci : Dakwah; Ekologi; Pesantren;
Matrix Metalloproteinase-2 in a Murine Model of Infantile-Type Polycystic Kidney Disease
Authors: RANKIN CAROLYN A. , ITOH YOSHIFUMI , TIAN CHUNQIAO , ZIEMER DONNA M. , CALVET JAMES P. , GATTONE VINCENT H. 
Published: May 2021

Abstract.
It was previously found that elevated levels of matrix metalloproteinase (MMP)-2 (gelatinase A) and -9 (gelatinase B) were synthesized and secreted into the medium by cultured kidney tubules derived from cystic C57BL/6J-cpk mice. To determine whether increased synthesis and secretion occur in vivo in this mouse model of polycystic kidney disease, kidney protein extracts, mRNA, and tissue sections were compared for expression and activity of MMP-2 and -9. Although both MMP were detected in tissue extracts, the differences in expression levels and activity in normal and cystic kidneys were far greater for MMP-2. High levels of MMP-2 seemed to result from increased expression by the cystic kidneys predominantly in the second and third postnatal weeks (a time when the kidneys are undergoing rapid cystic enlargement). Much of the increased MMP was present in the inactive zymogen form, although active enzyme was readily detected by sodium dodecyl sulfate-polyacrylamide gel zymography and in situ zymography. MMP-2 was abnormally localized to the interstitium and to foci between cysts, suggesting that MMP-2 may regulate collagen accumulation at those sites, thus allowing cyst enlargement and limiting the severity of interstitial fibrosis.
Late Consequences of Acute Ischemic Injury to a Solitary Kidney
Authors: PAGTALUNAN MARIA ENRICA , OLSON JEAN L. , TILNEY NICHOLAS L. , MEYER TIMOTHY W. 
Published: May 2021

Abstract.
The sequelae of acute ischemic injury to a solitary kidney were assessed in rats subjected to right nephrectomy and transient occlusion of the left renal artery; control rats underwent right nephrectomy alone. Incomplete recovery from ischemic injury at 2 wk (serum creatinine levels of 1.1 ± 0.2 versus 0.5 ± 0.1 mg/dl, P < 0.05 for ischemia versus control) was followed by deterioration of renal function at 20 wk (serum creatinine levels of 1.7 ± 0.4 versus 0.7 ± 0.1 mg/dl, P < 0.05 for ischemia versus control). Morphologic studies showed that impairment of function after ischemic injury was associated with widespread tubulointerstitial disease. Some tubule segments were atrophic and others exhibited cystic dilation, so that the tubular cell volume fraction was reduced (37 ± 4 versus 53 ± 2%, P < 0.05), while the tubular lumen and interstitial volume fractions were increased (31 ± 4 versus 23 ± 2% and 29 ± 2 versus 20 ± 1%, respectively, both P < 0.05). Many glomeruli retained open capillary loops but were no longer connected to normal tubule segments (63 ± 8 versus 15 ± 7% of glomeruli, P < 0.05). There was a strong inverse correlation between the prevalence of such glomeruli and the GFR at 20 wk after ischemia (r
2 = 0.79, P < 0.001). Tubulointerstitial disease at that time was accompanied by proteinuria and widespread segmental glomerular tuft injury. The occurrence of similar processes in human patients could contribute to the loss of graft kidneys that suffer ischemic injury during transplantation.
Neuropeptide Y and ATP Interact to Control Renovascular Resistance in the Rat
Authors: OBERHAUSER VITUS , VONEND OLIVER , RUMP LARS CHRISTIAN 
Published: May 2021

Abstract.
Neuropeptide Y (NPY) and ATP are cotransmitters of norepinephrine (NE). Modulation of ATP-mediated purinergic neurotransmission by NPY was investigated in rat perfused kidney. β,γ-Methylene-L-ATP (β,γ-mATP; 1.0 to 1.5 μM, n = 8), NE (0.1 μM, n = 8), and NPY (0.1 μM, n = 14) increased perfusion pressure by maximally 12 ± 1, 17 ± 2, and 9 ± 1 mmHg, respectively. In the presence of NPY, responses to ATP and NE were dramatically enhanced. Renal nerve stimulation in the presence of the α-adrenoceptor antagonist phentolamine (1 μM) induced pressor responses of 54 ± 5 mmHg (n = 6). α-Blockade-resistant responses were abolished by the P2-purinoceptor blocker suramin (300 μM) and thus mediated by ATP. Purinergic responses were also reduced significantly (50%) by the NPY-Y1 receptor blocker BIBP 3226 (1 μM). NPY (0.1 μM) potentiated purinergic pressor responses and enhanced ATP release from 0.7 ± 0.2 to 4.1 ± 0.9 pmol (n = 4) associated with a significant increase of soluble ATPase activity. All NPY effects were prevented by BIBP 3226. Pressor responses to renal nerve stimulation delivered at short time intervals, mimicking enhanced sympathetic drive to the kidney, were not constant but showed a progressive rise, which was prevented by BIBP 3226. In this study, it is suggested that purinergic vasoconstriction in rat kidney depends on concomitantly released NPY. NPY by itself is only a weak vasoconstrictor but acts as a modulator of renal vascular resistance by enhancing the effects of its sympathetic cotransmitters, especially during sympathetic overactivity.
The Terminal Sequence of Complement Plays an Essential Role in Antibody-Mediated Renal Cell Apoptosis
Authors: SATO TOSHINOBU , VAN DIXHOORN MIENEKE G. A. , PRINS FRANS A. , MOONEY ANDREW , VERHAGEN NICOLE , MUIZERT YVONNE , SAVILL JOHN , VAN ES LEENDERT A. , DAHA MOHAMED R. 
Published: May 2021

Abstract.
Mesangial cell (MC) injury is a characteristic feature in the early phase of Thy.1 nephritis. The present study investigates the contribution of complement to MC apoptosis in this experimental model of kidney disease in rats. Thy.1 nephritis was induced by injection of mouse anti-Thy.1 monoclonal antibody (ER4G). To assess the contribution of the terminal sequence of complement on apoptosis, the studies were performed in complement-sufficient PVG/c (PVG/c+) rats and in rats deficient in complement C6 (PVG/c-). Apoptosis was monitored by assessment of the number of condensed nuclei in kidney sections stained with periodic acid-Schiff (PAS) and by the terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL) method and expressed as number of apoptotic cells per 50 glomerular cross sections. In the PAS method, 1 h after intravenous injection of ER4G, PVG/c+ rats exhibited 160.9 ± 49.5 apoptotic cells, whereas PVG/c- rats had only 3.2 ± 1.4 apoptotic cells. Control rats exhibited 0.9 ± 0.6 apoptotic cells. These findings were confirmed with the TUNEL method. In PVG/c- rats, a maximum number of 8.8 ± 3.1 TUNEL-positive (TUNEL+) cells was found at 6 h followed by a decline thereafter. In PVG/c+ rats, apoptosis was associated with deposition of C6 and C5b-9. Restoration of the complement system of PVG/c- rats with purified human C6 resulted in an increase of apoptosis at 1 h after injection of ER4G from minimal numbers to 239.9 ± 52.4 TUNEL+ cells. These studies appear to indicate for the first time that the terminal sequence of complement is involved in induction of apoptosis.