bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research and Career Outcomes for Pediatric Hospital Medicine Fellowship Graduates
Authors: Rassbach Caroline E. , Fiore Darren ,   COUNCIL OF PEDIATRIC HOSPITAL MEDICINE FELLOWSHIP DIRECTORS
Published: October 2021

OBJECTIVES
Pediatric hospital medicine (PHM) fellowships have rapidly developed to meet established needs. The purpose of this research was to describe the research and career outcomes of PHM fellowship graduates. We hypothesized that graduates would report significant research and academic productivity.

METHODS
This was an institutional review board–approved, cross-sectional survey of PHM fellowship graduates in 2018. The 88-item survey was modified from an existing survey, developed by experts to address study objectives and pilot tested, and it included quantitative and qualitative items to assess characteristics of fellowship training and research and career outcomes.

RESULTS
A total of 63% of PHM fellowship graduates (143 of 228) completed the survey (graduation dates, 2000–2018). In total, 89% graduated from dedicated PHM fellowship programs, with 59% completing a 2-year fellowship and 78% now practicing primarily at a university or children’s hospital. Fellows conducted research in clinical research (53%), quality improvement (41%), health services (24%), and medical education (19%). A total of 77% of graduates continued to do research after graduation, with 63% publishing and 25% obtaining grant funding. Graduates of 2- and 3-year fellowships and those with a master’s degree were significantly more productive. Graduates now hold important roles in academic and health systems leadership. Graduates are highly satisfied with their decision to do PHM fellowship and identified 5 themes regarding how fellowship impacted their career outcomes.

CONCLUSIONS
In this study, we document robust research activity and leadership positions among PHM fellowship graduates and can serve as a benchmark for metrics that PHM educational leaders can use to assess outcomes and improve training regarding research and career development.
Flying Solo: Effectiveness of Attendingless Family-Centered Rounds on Improving Resident Autonomy
Authors: Jain Priya N. , Hametz Patricia , Banker Sumeet L. , Escalante Enrique , Gutierrez Fatima , Dodoo Christopher , Dwivedi Alok K. , Beck Jimmy , Fromme H. Barrett 
Published: October 2021

BACKGROUND AND OBJECTIVES
The Accreditation Council for Graduate Medical Education requires that residents demonstrate increasing autonomy during their training. Although residents report a better educational environment with hospitalists present during family-centered rounds (FCRs), there is a concern that attending presence may reduce resident autonomy. We aim to determine the effect of FCRs without an attending during rounds on senior residents’ sense of autonomy.

METHODS
We conducted a multicenter, retrospective, preintervention-postintervention study at 5 children’s hospitals to evaluate the effect of rounding without an attending on senior residents’ self-efficacy, using a questionnaire developed by using Bandura’s principles of self-efficacy and Accreditation Council for Graduate Medical Education milestones. Questions addressed skills of diagnosis and/or management, communication, teaching, and team management. We compared preintervention and postintervention results using paired t tests and Wilcoxon rank tests. One-way analysis of variance tests were used to compare means among &gt;2 groups.

RESULTS
116 (82% response rate) of 142 eligible senior residents completed the questionnaire, which yielded a high reliability (α = 0.80) with a 1-factor score. The average composite score of self-efficacy significantly improved after intervention compared with the preintervention score (66.71 ± 6.95 vs 60.91 ± 6.82; P &lt; .001). Additional analyses revealed meaningful improvement of each individual item postintervention. The highest gain was reported in directing bedside teaching (71.8% vs 42.5%; P &lt; .001) and answering learner questions on rounds (70.7% vs 47.0%; P &lt; .001).

CONCLUSIONS
Conducting FCRs without an attending increases resident reported self-efficacy regarding core elements of patient care and team leadership. In future studies, researchers should examine the impact of rounding without the attending on other stakeholders, such as students, interns, patients and/or families.
Ketamine-assisted psychotherapy for trauma-exposed patients in an outpatient setting: A clinical chart review study
Authors: Davis Alan K. , Mangini Pratheek , Xin Yitong 
Published: October 2021

Abstract
Trauma exposure across the lifespan produces risks for posttraumatic stress disorder (PTSD), depression, anxiety, as well as global disability in functioning. This retrospective clinical chart review is the first of its kind to assess the utility of sublingual ketamine-assisted body-centered psychotherapy in trauma-exposed patients in a real world clinic setting. De-identified clinical records data on self-reported symptom measures were retrospectively analyzed for patients (N = 18; M
age = 45.22, SD = 12.90) entering ketamine-assisted psychotherapy treatment in an outpatient clinic between 2018 and 2020. Patients who completed six sessions of ketamine therapy reported meaningful (e.g., medium effect size) improvements in PTSD symptoms (P = 0.058; d = −0.48) and global disability in functioning (P = 0.050; d = −0.52) and statistically significant and meaningful improvements in depression (P = 0.019; d = −0.53). There were no improvements in anxiety symptoms. Sublingual ketamine-assisted psychotherapy was associated with heterogenous clinical utility among patients with trauma-exposure in an outpatient setting. This study was underpowered and unrepresentative of the population of ketamine patients in the United States. Replication of these findings is needed with larger and more diverse patient samples.
EVALUATION OF PELVIC VENOUS DILATATION WITH COMPUTED TOMOGRAPHY IN PATIENTS WITH CELIAC DISEASE
Authors: DÜNDAR İlyas , GOYA Cemil , TÜRKO Ensar , ÖZKAÇMAZ Sercan , ÖZGÖKÇE Mesut , DURMAZ Fatma , AYYILDIZ Veysel  Atilla 
Published: October 2021

Objective
Celiac disease (CD) is characterized by an immune
response in genetically gluten-sensitive individuals
resulting in inflammatory damage of the small
intestine. The radiological identification of pelvic
venous dilatation (PVD) is important as it can
contribute to the diagnosis of different spectrums of
pelvic and systemic diseases. In our study, we aimed
to determine the prevalence of PVD in CD patients
and to present our findings with the literature.
Materials and Methods
This retrospective observational study was approved
by the institutional review board in our institution. All
patients were patients diagnosed with CD by clinical
evaluation, serological data, and intestinal biopsy,
and who underwent CT between October 2011
and March 2020 in our medical center. CD patients
(n=149) and control group (n=250) who had contrastenhanced
CT were evaluated for PVD. In all patients,
PVD prevalence was examined in the patient and the
control group. The diameter of the pelvic veins was
measured and noted. Complaints of the patients were
noted from the hospital records.
Results
Among a total of 149 histopathologically proven patient
groups, there were 93 female and 56 male patients
with a mean age of 35.11±13.03 and 36.23±15.06
years, respectively. Among a total of 250 control
groups; there were 145 females and 105 males with
a mean age of 38.65±15.38 and 37.25±13.56 years,
respectively. PVD prevalence in the female and
male were 60.22% (n=56) and 41.07% (n=23) in CD
patients, respectively. 46.75% (n=36) CD patients
had abdominal pain and were correlated with PVD
(p
Un año de edición en Wikipedia: el caso del artículo «COVID-19» en diez lenguas
Authors: Tavares Lourenço Ricardo 
Published: October 2021

Wikipedia, a big collective and collaborative work by its linguistic magnitude, has permitted to appreciate the writing and editing evolution of articles about emergent and changing themes as more and more data is revealed of different sources. After a year of official declaration of the World Health Organization of the COVID-19 pandemic existence, and the officialization of the disease´s name, it is an enough cycle to analyze how the editing of «COVID-19» article has been done since February 2020. Because of this, the available statistics in each version in the ten languages of the countries with more contagions were revised (English, German, French, Russian, Italian, Spanish, Chinese, Portuguese, Turkish and Hindi), and the number of editors involved on the volume and frequency of editions, rate of editing month to month were analyzed. In addition, the subtitles of the article in each studied language were compared to verify their order and hierarchy. The aim of this study is to consider no only the information’s density availability, but also to understand the weighing of some languages over others on popular science texts. We found out that the more number of editors, the longer and denser the articles are, and they prefer publishing information in global languages, regardless of the case number of contagions. Also, the editors agree on the order of the subtitles considering the target.
NILAI-NILAI ENTREPRENEUR PADA BUKU TEKS MATA PELAJARAN SEJARAH DAN IMPLEMENTASINYA DI SMA NEGERI 1 INDRALAYA
Authors: Dhita Aulia Novemy , Asmi Adhitya Rol , Yunani Yunani 
Published: October 2021

Historical events have a lot of treasure that contains learning values, one of which is entrepreneurial values. This value is very important in educating students, with historical material in textbooks such as Arrived Hindu-Buddha in Indonesia, Hindu-Buddha Kingdom in Indonesia, Islam Kingdom in Indonesia, and History of Colonial in Indonesia, which so far have only been memorized as events only. The great potential contained in the history textbook, becomes the background for analyzing the values of entrepreneurs in the use of history textbooks in Senior High School Number 1 in Indralaya. This study aims to get clear any material that contains the values of entrepreneurs in history textbooks at Senior High School Number 1 in Indralaya. The method used in this research is naturalistic qualitative research. Data collection is done by observation, documentation, and triangulation, while data analysis is done by reducing, describing data and drawing conclusions. The results showed that history textbooks contain entrepreneurial values that are independent, creative, risk-taking, action-oriented, leadership, hard work, concepts and skills Masa lalu menyimpan banyak harta karun yang mengandung nilai-nilai pembelajaran, salah satunya nilai-nilai entrepreneur. Penerapan nilai-nilai entrepreneur tidak hanya melalui kegiatan praktek wirausaha, tetapi dapat diterapkan melalui buku teks pelajaran, sehingga mengandung niai-nilai entrepreneur. Salah satunya buku teks mata pelajaran sejarah SMA. Sangat penting untuk mengetahui kandungan entrepreneur dalam buku teks mata pelajaran sejarah SMA dan penerapannya di sekolah. Potensi besar yang terdapat dalam buku teks sejarah tersebut, menjadi latar belakang untuk melakukan analisis nilai-nilai entrepreuner dalam penggunaan buku teks mata pelajaran Sejarah di SMA Negeri 1 Indralaya.Penelitian ini bertujuan untuk mendapatkan secara jelas materi apa saja yang mengandung nilai-nilai entrepreneur dalam buku teks mata pelajaran Sejarah dan implementasinya di SMA Negeri 1 Indralaya. Metode yang digunakan dalam penelitian ini adalah penelitian kualitatif naturalistik. Pengumpulan data dilakukan dengan observasi, wawancara, dokumentasi dan triangulasi. Sedangkan analisis data dilakukan dengan mereduksi, menguraikan data dan menarik kesimpulan. Hasil penelitian menunjukkan bahwa buku teks sejarah mengandung nilai-nilai entrepreneur yaitu mandiri, kreatif, berani mengambil resiko, berorientasi pada tindakan, kepemimpinan, kerja keras, konsep dan skill/keterampilan. Implementasi nilai-nilai entrepreneur yang terkandung dalam buku teks mata pelajaran sejarah, dilakukan secara tidak langsung oleh guru sejarah, dalam berbagai kegiatan di sekolah. KATA KUNCINilai, Entrepreneur, Buku Teks, Sejarah
Acute Transient Macular Edema after Uneventful Cataract Surgery
Authors: Beisekeeva J. S. , Bezrukov A. V. , Kochergin S. A. , Samoylenko A. I. 
Published: October 2021

Purpose: to provide a clinical case of recurrent keratoconus from our practice.Materials and method. A patient came to the clinic with a complaint of decreased visual acuity in the right eye. A series of standard instrumental examinations and Scheimpflug keratotopography were performed, and astigmatism of the right eye was diagnosed. Similar examinations were carried out during the patient’s attendance at follow-up examinations.Results. Based on the results of scanning Scheimpflug keratotopography, the diagnosis of keratoconus (forme fruste) was made. On examination after 1 year, there were no complaints of decreased visual acuity and data from the same instrumental examinations indicating keratoconus. After this examination, the patient came 3.5 years later with complaints of a new decreased visual acuity in the right eye. During instrumental examinations and keratopography, data were obtained indicating the presence of posterior keratoconus. After 1 year, a follow-up examination took place without complaints. The data of instrumental studies are identical to the previous visit; keratotopography revealed a decrease in posterior elevation.Discussions and conclusion. It was revealed that the patient was constantly taking the hydroxyurea drug against the background of systemic disease up to the 3rd visit, at the time of the 4th visit she had not taken it for 1 year. There are publications in the literature on the effect of this type of drugs on the collagen of the dermis of the skin, the type of which corresponds to the collagen of the cornea. We hypothesize that drugs may have an effect on the biomechanical properties of the cornea, which requires further in-depth study.
Expert (Medical) Assessment of the Main Patients Complaints with Computer Visual Syndrome
Authors: Ovechkin I. G. , Kovrigina E. I. , Leksunov O. G. , Konovalov M. E. 
Published: October 2021

The purpose is to conduct an expert (medical) assessment of the main complaints of patients with symptoms of computer visual syndrome (CVS).Methods: as part of the preliminary stage of work, an individual interview was performed (according to the standard developed methodology) with 100 patients aged 24–36 years, whose professional daily activity (at least 2 years) was characterized as visually-intense work associated with electronic systems displaying information (at least 4 hours a day) and with a fairly high level of responsibility for the final result. During the main stage of the study, a special questionnaire was developed, in which the identified complaints were transformed into questions. The task of the expert — ophthalmologist was to assess the relevance of each of the questions in terms of the severity of the impact on the “quality of life” of the patient. In this case, the assessment was carried out on a 10-point scale, where 0 points — the question is not relevant; 10 points — the question is very relevant. The study involved 96 ophthalmologists aged 41.3 ± 1.6 years (age range from 32 to 62 years) with an average of 17.3 ± 1.4 years of professional experience (range from 6 to 37 years).Results: more pronounced “ocular” manifestations of the CVS were established (mean score — 8.0 ± 0.2, range from 5.0 to 9.4 points, the highest scores for 8 complaints from 8.6 to 9.4 points) compared with “visual” (average score — 6.5 ± 0.2, range from 4.1 to 8.8 points, the highest scores for 5 complaints from 7.8 to 8.8 points). A sufficiently high level of practical significance of “professional” subjective manifestations of the CVS has been established.Conclusion. The obtained data can be basic in the framework of the prospective development of a questionnaire for assessing the “quality of life” of patients with CVS symptoms, since the use of an expert (medical) assessment of identified complaints from the position of the severity of a change in subjective status significantly increases the level of reliability, reliability, as well as meaningful and constructive validity methods of assessing the “quality of life”.
Retinoblastoma Morphology after Local Chemotherapy
Authors: Saakyan S. V. , Khoroshilova-Maslova I. P. , Tadevosyan S. S. , Tsygankov A. Yu. , Zakharova G. P. , Ivanova O. A. , Panteleeva O. G. , Zharua A. A. 
Published: October 2021

Purpose. Determine the nature of tumor regression and possible complications associated with the retinotoxic effect of melphalan and carboplatin with local chemotherapy.Methods. A histological analysis of 19 enucleated eyes from 19 patients with retinoblastoma was performed after combined organ-preserving treatment, including systemic chemotherapy and local chemotherapy in various doses. The enucleated eyes were fixed in 10 % formalin and processed routinely for histological examination.Results. Significant changes in the tumor tissue such as tumor regression associated with the destruction of the tumor tissue and its replacement with fibrous tissue, glia proliferation, and the formation of petrificates were revealed. Complete regression of the tumor was detected in 3 out of 19 eyes, partial in 13 eyes. There were no signs of regression in 3 eyes. Tumor invasion into the choroid was found in 5 cases, into the anterior sector — in 3 cases, into the optic nerve — in 3 cases. The retrobulbar tumor was presented in 1 case. Retinotoxic complications revealed. Hemorrhagic changes associated with focal necrosis of the central retinal vessels (n = 4), destructive changes in retinal pigment epithelium (RPE; n = 10) associated with the accumulation of melphalan in RPE leading to atrophic processes in the retina. Complications in the form of secondary glaucoma, severe fibrosis and retinal detachment, despite the complete resorption of the tumor, led not only to loss of vision, but also hindered visualization of the fundus and substantiated the need for enucleation in 3 cases. In other cases, enucleation was performed due to continued tumor growth (n = 16) or progression during treatment (n = 3).Conclusions. Retinoblastoma can be controlled with local chemotherapy. However, clinical and morphological examinations of enucleated eyes revealed and confirmed, along with tumor resorption, intraocular complications as a result of the toxic effect of the drugs and the presence of active tumor tissue to varying degrees of therapeutic pathomorphism, which can be explained by the resistance of RB to these drugs. Thus, a further search is needed for drugs that destroy the tumor and minimize the retinotoxic effect.
Effect of Platelet-Riched Plasma on Corneal Epithelium Regeneration during Its Chronic Erosion (Experimental Study)
Authors: Tarabrina V. A. , Gavrilyuk I. O. , Churashov S. V. , Muravyeva O. A. , Chirskii V. S. , Troianovskii R. L. , Kulikov A. N. 
Published: October 2021

Relevance. In a number of pathological conditions accompanied by defects of the basal membrane, such as chemical or thermal burn, mechanical trauma, Schegren’s syndrome, herpetic keratitis processes of corneal epithelization are slowed down, and sometimes epithelization does not occur at all. Slow epithelization or its complete absence creates conditions for infection, thinning, and sometimes perforation of the cornea. That is why the problem of chronic corneal erosions is very relevant. The most perspective method of treatment is the use of autologous platelet-riched plasma (PRP). Presence of platelet growth factors, adhesive molecules and cytokines in PRP allows to use it for acceleration of regeneration of corneal defects, and the presence of live platelets allows to refer this procedure to autologous cell transplantations.Objective: To evaluate the clinical and morphological features of corneal epithelium regeneration in response to the application of PRP in conditions of experimental chronic corneal erosion (ECCE).Materials and methods. Researches were carried out on 12 rabbits of Chinchilla breed (24 eyes). At first stage the model of ECCE was reproduced for all animals: local ultraviolet (UV) irradiation with the exposure time of 45 min. on the preliminary de-epithelized corneal surface. At the second stage all animals under study were divided into three groups (4 rabbits in each group). I-st main group (MG) was instillated with PRP at a rate of 1 drop / 1 min within 10 minutes (total of 10 drops) once, in the II MG treatment was carried out according to the above method, every day for 5 days. In the control group (CG) PRP treatment was not applied.Results. 45-min. UV irradiation causes persistent ECCE up to 30 days of the experiment and reverts only after surface vessels are ingrowed in the affected area. Single use of PRP has insufficient therapeutic effect. Instillation within 5 days accelerates the cornea reparative regeneration in ECCE conditions. The absence of epithelial defect, newly formed vessels and corneal clouding was registered on the 9th day. Histologically, on the 30th day a normal multilayer non-squamous epithelium was found, while the stroma had an organized structure with no signs of inflammation.Conclusions. Therapeutic effect of PRP in ECCE conditions is based on reforming of the normal «adhesion complex» between epithelium, olfactory membrane and multifactor stimulation of reparative regeneration due to growth factors located in it, adhesive molecules and cytokines, as a result of which the typical corneal epithelium is restored.
Neuroprotective role of Ginkgobiloba and Rosuvastatin in CA1 region of Hippocampus against high fat diet induced neurotoxicity
Authors: Kumar Anil , Acharya Anand , Velichety Subhadra Devi , Vaderav Rajesh 
Published: October 2021

Diet rich in fat is one of the main risk factor for the development of Alzheimer’s disease. Studies have shown that diet rich in fat disrupts memory and learning. The present study evaluates the ameliorative role of Ginkgobiloba and Rosuvastatin against high fat diet induced neurotoxicity in CA1 (Corona Ammonis) region of hippocampus. Animals were randomly divided into six groups. Group I received normal diet, Group II received high fat diet, Group III & IV were treated with Ginkgobiloba 50mg/kg and 100mg/kg body weight, and Group V & VI were treated with Rosuvastatin 10mg/kg and 20 mg/kg body weight. All the rats were subjected to spatial learning (Morris water maze). Subsequently, rats were sacrificed and brains were removed. Golgi staining was done and CA1 neurons of hippocampus were traced using camera lucida. Dendritic branching points and dendritic intersections were quantified. Lipid profile and Super oxide (SOD) was also estimated.There was enhancement of spatial learning in treatment group rats. Furthermore, a significant increase in dendritic length and branching points was observed in CA1 region along with significant decrease in the Superoxide dismutase in rats treated with higher dose of Ginkgobiloba and Rosuvastatin. Present study concludes that Ginkgobiloba and Rosuvastatin in higher dose have protective role against high fat diet induced neurotoxicity in CA1 region.