bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug Repurposing for Coronavirus (COVID-19): In Silico Screening of Known Drugs Against the SARS-CoV-2 Spike Protein Bound to Angiotensin Converting Enzyme 2 (ACE2) (6M0J)
Authors: Kalamatianos Konstantinos 
Published: March 2021

E3/03-03-2021Molecular Dynamics Simulation has been added to E2/21-12-2020E2/21-12-2020In this study FDA approved HCV antiviral drugs and their structural analogues – several of them in clinical trials - were tested for their inhibitory properties towards the SARS-CoV-2 Spike protein bound to angiotensin converting enzyme 2 (ACE2) (6M0J) using a virtual screening approach and computational chemistry methods. The most stable structures and the correspond-ing binding affinities of thirteen such antiretroviral com-pounds were obtained. Frontier molecular orbital theory, global reactivity descriptors, molecular docking calculations and electrostatic potential (ESP) analysis were used to hypothesize the bioactivity of these drugs against 6M0J. It is found that increased affinity for the protein is shown by inhibitors with large compound volume, relatively higher electrophilicity index, aromatic rings and heteroatoms that participate in hydrogen bonding. Amongst the drugs tested, four compounds 10-13 showed excellent results – binding affinities -11.2 to -11.5 kcal.mol-1. These four top scoring compounds may act as lead compounds for further experimental validation, clinical trials and even for the development of more potent antiviral agents against the SARS-CoV-2. E1/24-08-2020In this study FDA approved antiviral drugs and lopinavir analogues in clinical trials were tested for their inhibitory properties towards the SARS-CoV-2 Spike protein bound toangiotensin converting enzyme 2 (ACE2) (6M0J) using a virtual screening approach and computational chemistry methods. Amongst the drugs tested, four compounds, PubChem CID 492005, CID 486507, CID 3010249 andlopinavir showed excellent results – binding interactions -9.0 to -9.3 kcal.mol-1. These four top scoring compounds may act as lead compounds for further experimental validation, clinical trials and even for the development of more potent antiviral agents against the SARS-CoV-2.
TRAVELER’S KNOWLEDGE AND ATTITUDES TO ACCESS TOURISM HEALTH CENTRE AT GUNUNGKIDUL: CASE STUDY AT INDRAYANTI BEACH
Authors: Lating Noval Ali , Sofiana Liena 
Published: March 2021

Background: Indrayanti beach located at Gunungkidul district, Yogyakarta. The number of tourists visited this beach has increased each year, meaning that it increases the health risks for the tourist and people involved, such as infectious diseases, blisters, lost, injured by objects or marine animals, sea water irritation. However, according to the previous study, a traveler who is accessing the Tourism Health Centre is low. This research aimed to identify the relationship between knowledge and attitude of the travelers in Indrayanti Beach to the traveler’s access to the Tourism Health Centre.Method: Quantitative analytical approach with a cross-sectional study design was applied in this study. Of 106 travelers was participate in this study that was recruited through accidental sampling. A tested questionnaire contained knowledge, and attitude was asked to the Indrayanti visitor. A Chi-square test was used to analyze the result.Results: There is a significant association between knowledge level (p=0.027) and attitude (p = 0.000) to the willingness to access the Tourism Health Centre. Conclusion: Knowledge and attitude are the primary aspects of the willingness to access the Tourism Health Centre.
THE DIFFERENT MENTAL HEALTH PATIENT QUALITY OF LIFE DURING SHACKLING, TREATMENT, AND POST TREATMENT
Authors: Widodo Arif , Supratman Supratman 
Published: March 2021

Background: Mental health is a well-being mental state associated with happiness, joy, satisfaction, achievement, optimism, and hope. Good mental health allows a harmonious and productive life as an integral part of one's quality of life by taking into account all aspects of human life. This study aims to assess the different quality of life among mental health disorder patients during shackling, treatment, and post-treatment in Sukoharjo Regency.Methods: Quantitative descriptive was used in this study. Our population was all mental disorder patient in Sukoharjo District who has experienced with shackling and finished the treatment in the RSJD “dr Arif Zainudin," Surakarta during 2011-2015. We took total sampling and excluded patients who died, move to another place, and recover. Thirty out of thirty-four post-shackling patients in the Sukoharjo Regency participated in this study. A tested questionnaire was used to collect the data from the patient. The analysis was performed using univariate analysis – central tendency value analysis. Results: We found differences in patients' quality of life during shackling, treatment, and post-treatment. The survivor had the highest quality of life in the post-treatment phase compared to the shackled and treatment period.Conclusions: The quality of life of post-treatment patients is better compared during shackled and treatment.
Formation of City Brand in the Implementation of the Concept of Integrated Development
Authors: Hryhorieva Olesia , Khadartsev Oleksandr , Ivaniuk Artem 
Published: March 2021

Modern realities and requirements for sustainable development of territories need ensuring diversity and a certain identification of each city. The relevance of this process is enhanced in terms of implementing the concept of integrated urban development, so the purpose of the article is defined as a spare impact on the formation of the personal brand of the city in the process of successful implementation of integrated development planning. The development and implementation of the concept of integrated development in the cities of Ukraine significantly contributes to the formation of city branding, puts the task of developing and implementing the city brand in the foreground, and provides an opportunity to borrow successful branding experience of European cities. The result of such work is the formulation of a common vision of what the city wants to be, what and how it should achieve, the definition of strategic, operational goals and objectives, among which you can clearly trace the main directions of the city's branding. The foundations of the city's branding are laid in the most important areas of its development, as well as in the visions of the city, which create an opportunity to develop and apply your own brand.
Perbandingan Pengaruh Ekstrak Lidah Buaya (Aloe vera) dan Ekstrak Daun Sirih (Piper betle Linn) Terhadap Kualitas Produk Hand Soap
Authors: Robbia Annisa Zikri , Yahdi Yahdi , Dewi Yuli Kusuma 
Published: March 2021

Dalam pembuatan sabun cuci tangan biasanya memanfaatkan ekstrak alami yang dapat membunuh bakteri. Salah satu bahan alam yang biasa dijumpai adalah Lidah buaya (Aloe Vera) dan daun sirih (Piper betle Linn) yang memiliki banyak khasiat. Tujuan penelitian ini adalah untuk melihat kualitas Hand Soap baik dari ekstrak lidah buaya maupun ekstrak daun sirih. Analisis data menggunakan One-way ANOVA (Analysis of Varians) pada taraf 5%. Percobaan penelitian ini menggunakan 3 sampel yaitu Hand Soap tanpa ekstrak (sebagai kontrol), Hand Soap ekstrak lidah buaya (Aloe vera) dan Hand Soap ekstrak daun sirih (Piper betle Linn). Parameter kualitas yang diamati adalah uji organoleptik, pH, viskositas, antibakteri, dan daya busa. Hasil penelitian menunjukkan bahwa kualitas Hand Soap ekstrak daun sirih memenuhi standar SNI dengan rata-rata uji organoleptik 3,87; pH 8,23; viskositas 20486,17 cPs; daya antibakteri 13,97 mm; dan daya busa 27,75 mm, sedangkan pada Hand Soap ekstrak lidah buaya juga memenuhi standar SNI dengan skor uji organoleptik sebesar 4,20; pH 8,68; daya antibakteri 9.12 mm; dan daya busa 27,50 mm. Berdasarkan uji statistik dan uji lanjut BNT disimpulkanÃÂ bahwa terdapat perbedaan yang signifikan pada penambahan ekstrak daun sirih dan ekstrak lidah buaya terhadap kualitas Hand soap pada parameter pH, viskositas, dan daya antibakteri, dimana ekstrak daun sirih memiliki pengaruh paling baik terhadap kualitas Hand Soap dibandingkan dengan Hand soap kontrol dan Hand soap ekstrak lidah buaya.
Katsooko metsä ihmistä?
Authors: Seppä Tiina 
Published: March 2021

Tarkastelen tässä artikkelissa metsää ja ihmisen kommunikaatiota sen kanssa suomalais-karjalais-inkeriläisessä kansanrunoudessa. Suomen Kansan Vanhat Runot (SKVR) on laaja ja edustava kokoelma pääasiassa suomalais-karjalais-inkeriläistä, suullisesti välittynyttä runoutta, joka on tallennettu etupäässä 1800-luvulla ja 1900-luvun alkuvuosikymmeninä, mutta sen varhaisimmat runotallenteet ovat 1500-luvulta. Suullisen runon maailma sisältää runsaasti kommunikaatiota ei-inhimillisen kanssa, ja tästä kommunikaatiosta suuri osa tapahtuu elinympäristön luonnonentiteettien kanssa vuoropuhelussa. Runoudessa on runsaasti suoraa dialogia metsän kanssa, ja metsä näyttäytyy siinä omalakisena toimijana, jonka moraliteettia tai tarkoitusperiä ei voida ennustaa saati määrätä. Toisaalta SKVR sisältää runsaasti runoja, joissa runon kertojaminä kertoo kommunikoivansa luonnon entiteettien, esimerkiksi lintujen kanssa, luotettavien ja muuten mahdollisten ihmiskontaktien puuttuessa. Näissä runoissa yhteisöstä vieraantunut saatetaan nähdä anomalisen kykynsä vuoksi erityislahjakkuutena.
Metsä on miesten runoudessa mahdollisen eroottisen kanssakäymisen osapuoli ja naisten huolirunoudessa usein turvapaikka ja luotettu, hyvä toinen. Metsä voi olla naiselle myös omaehtoisen seksuaalisuuden ilmaisemisen paikka. Runoissa ollaan selvillä metsän ja sen entiteettien tietoisesta läsnäolosta: metsä katsoo ihmistä.
Pengaruh Model Inquiry Training Terhadap Hasil Belajar Siswa Pada Materi Pokok Elastisitas Dan Hukum Hooke
Authors: Sinaga Beni , R. Manurung Sondang 
Published: March 2021

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran inquiry training terhadap hasil belajar siswa pada materi elastisitas dan hukum hooke. Jenis penelitian yaitu quasi experiment. Populasi dalam penelitian adalah seluruh siswa kelas XI Semester I SMA Negeri 1 Parbuluan yang terdiri dari empat kelas MIA. Sampel penelitian yaitu kelas XI MIA-1 sebagai kelas eksperimen dan kelas XI MIA-2 sebagai kelas kontrol, masing-masing berjumlah 35 orang yang ditentukan dengan cara cluster random sampling. Instrumen yang digunakan adalah tes hasil belajar. Berdasarkan hasil penelitian diperoleh nilai rata-rata pretes kelas eksperimen 32,00 dan nilai rata-rata pretes kelas kontrol 28,37. Nilai postes di kelas eksperimen memperoleh nilai rata-rata 64,57 dan kelas kontrol 55,62. Berdasarkan hasil analisis uji t disimpulkan bahwa ada perbedaan akibat pengaruh model pembelajaran inquiry training terhadap hasil belajar siswa pada materi elastisitas dan hukum hooke di kelas XI semester I SMA Negeri 1 Parbuluan, dari T.P. 2019/2020.
Analisis Kemampuan Pemecahan Masalah Matematika Berdasarkan Taksonomi Structure of Observed Learning Outcomes (SOLO)
Authors: Halimah Halimah , Untu Zainuddin , Suriaty Suriaty 
Published: March 2021

Jenis penelitian ini adalah deskriptif kualitatif dengan tujuan untuk mengetahui dan mengklasifikasikan kemampuan pemecahan masalah matematika siswa berdasarkan Taksonomi Structure of Observed Learning Outcomes (SOLO) pada materi barisan dan deret di MA Negeri 1 Samarinda tahun ajaran 2019/2020. Subjek penelitian adalah siswa kelas XI IPA di MA Negeri 1 Samarinda yang berjumlah 66 orang. Objek penelitian adalah kemampuan pemecahan masalah siswa pada materi barisan dan deret berdasarkan Taksonomi SOLO. Instrumen yang digunakan dalam penelitian ini adalah soal tes pemecahan masalah dan pedoman wawancara. Hasil penelitian menunjukkan bahwa, dari 66 subjek diperoleh 5 siswa dengan kategori kemampuan prastruktural, 15 siswa dengan kategori kemampuan unistruktural, 29 siswa dengan kategori kemampuan multi-struktural, 14 siswa dengan kategori kemampuan relasional, dan 3 siswa dengan kategori kemampuan kategori abstrak yang diperluas. Dengan demikian disimpulkan bahwa, berdasarkan klasifikasi Taksonomi SOLO, kemampuan pemecahan masalah siswa kelas XI IPA di Madrasah Aliyah Negeri 1 Samarinda sebagian besar berada pada kategori kemampuan multistruktural yang berarti memenuhi indikator taksonomi SOLO pada tingkatan unistruktural dan tingkatan multistruktural.
Analisis Kesulitan Menyelesaikan Soal Matematika Materi Operasi Hitung Bilangan Pecahan Siswa Kelas VII
Authors: Dewi Novita Karina , Untu Zainuddin , Dimpudus Ariantje 
Published: March 2021

Penelitian ini merupakan penelitian deskriptif kualitatif dengan tujuan untuk mengetahui dan mendeskripsikan kesulitan-kesulitan siswa dalam menyelesaikan soal matematika materi operasi hitung bilangan pecahan. Subjek dalam penelitian ini adalah siswa kelas VII yang berjumlah 68 siswa. Pengumpulan data dilakukan melalui observasi, tes tertulis dan wawancara. Data yang terkumpul dianalisis berdasarkan tahapan mentranskrip data, memberi kode, mereduksi data, menyajikan data dan membuat kesimpulan. Hasil penelitian menunjukkan indikasi siswa yang mengalami kesulitan diantaranya, siswa tidak dapat memahami penjelasan dari guru, saat mengerjakan soal siswa tampak gelisah dan jawaban beberapa siswa yang acak-acakan serta coretan atau tulisan tidak jelas dan tidak terarah, meskipun jawabannya mendekati benar. Dari hasil analisis, disimpulkan kesulitan-kesulitan siswa dalam menyelesaikan soal materi operasi hitung bilangan pecahan yaitu kesulitan dalam menggunakan konsep, kesulitan dalam menggunakan prinsip dan kesulitan dalam menyelesaikan masalah-masalah verbal. Temuan lainnya, diketahui bahwa siswa yang memiliki nilai diatas kriteria ketuntasan minimal (KKM) juga mengalami kesulitan dalam menyelesaikan soal matematika materi operasi hitung bilangan pecahan.
LPKF-LDS technology for the production of three-dimensional schemes on plastics
Authors: Ivanov V. S. , Gladky D. A. , Vorunichev D. S. 
Published: March 2021

A promising technology for the production of three-dimensional circuits on plastics, the scope of its current application and prospects for its further development in the radio-electronic industry are considered. The analysis of current opportunities and limitations is carried out. It is shown that the key component of the technology is the correct choice of thermoplastics with suitable characteristics for the intended object, taking into account the resistance to external factors. An analysis of the international and domestic regulatory framework for thermoplastics was conducted. This allowed to determine the key characteristics for 3D-MID-technology and to make a comparison. A classification is proposed on the basis of the key characteristics of thermoplastics for making a decision when choosing materials on the market, taking into account the application in the radio-electronic industry using 3D-MID technology, which is currently either absent or not fully represented. Methods of testing materials for use in the production technology of three-dimensional circuits on plastics and ensuring the quality of manufacturing of radio engineering products, allowing to confirm the compliance of key parameters of materials are studied. The article considers the order of the build process with the application of the LPKF-LDS technology production of three-dimensional circuits on plastics, which allows building a sequence of processes with particular implementation as an example. The considered LPKF-LDS technology as part of the 3D-MID line is planned in the new laboratory “Threedimensional circuits on plastics and flexible media” at the Department of Design and Production of Radioelectronic Devices of the Institute of Radio Engineering and Telecommunications Systems of MIREA – Russian Technological University.
PENERAPAN IPTEKS PRODUK KEMPLANG PANGGANG BERKALSIUM DI UMKM IBU PERMAYANTI DESA PANTAI
Authors: Dasir Dasir , Asiati Diah Isnanini , Yuniarti Erliza , Suyatno Suyatno 
Published: March 2021

Kemplang panggang atau kemplang tunu adalah makanan tradisional yang disukai masyarakat karena memiliki rasa gurih, dan aroma khas. Bahan baku kemplang panggang adalah ikan giling dan tepung tapioka dan garam dapur. Kendala aspek produksi pada kemplang panggang adalah ikan bersifat musiman, penggiling ikan masih manual, kesulitan penjemuran saat penghujan, ukuran tidak seragam dan aspek kesehatan. Guna mengatasi permasalahan tersebut tim pengabdian masyarakat mengusulkan: 1) pembuatan dan penyimpanan ikan giling/surimi 2) Pembuatan pengering berbasis solar cell dengan Teknologi Tepat Guna (TTG) 3) mengganti mesin giling ikan manual dengan giling elektrik 4) Penggunaan cetakan kemplang 5) Penggunaan pakain kerja yang hygiene (clemek, masker, penutup kepala dan sarung tanggan). Tujuan Program Kemitraan Masyarakat adalah Transfer knowladge hasil penelitian, membina UMKM dan membantu mengatasi persoalan yang dihadapi UMKM.Hasil kegiatan ini mitra telah melakukan perubahan-perubahan pada aspek produksi dan hygiene sanitasi: 1) Penggunaan mesin giling ikan elektrik 2) penggunaan freezer untuk penyimpanan surimi/ikan giling sehingga peningkatan produktivitas mitra sampai dengan 150% 3) penggunaan pengering surya cell saat musim penghujan 4) Penggantian peralatan berbahan plastik daur ulang dengan perlatan stainless 5) Penggunaan pakain kerja (tutup kepala, clemek dan sarung tangan).
Taller de objetos de aprendizaje multimedia para compartir
Authors: Fonseca Chiu Lotzy Beatriz 
Published: March 2021

El trabajo tiene como finalidad difundir los resultados de implementar un taller de objetos de aprendizaje multimedia, en el cual jóvenes universitarios desarrollaron objetos de aprendizaje que incluían contenido multimedia y esos objetos de aprendizaje se compartían exponiéndose en diferentes escuelas de diversos niveles educativos como preescolar, primaria y preparatoria, los objetos de aprendizaje se crearon en la materia de Programación de sistemas multimedia en los calendarios 2013 B y 2014 A materia que imparto en el Centro Universitario de Ciencias Exactas e Ingenierías (CUCEI) de la Universidad de Guadalajara.
The paper aims to disseminate the results of implementing a workshop objects multimedia learning, in which university students developed learning objects including multimedia content and those learning objects shared exposing in different schools of different educational levels as preschool, primary and high school, learning objects are created in the field of multimedia systems programming calendars 2013 B and 2014 A subject that I teach at the University Center of Exact Sciences and Engineering (CUCEI) at the University of Guadalajara Sciences.
El análisis de unidades de tiempo dedicadas a cada área del conocimiento de un programa educativo, como instrumento para valorar un proceso de autoevaluación efectivo
Authors: Pérez Pizano S. Elías 
Published: March 2021

Este artículo que lleva como título “El análisis de unidades de tiempo dedicadas a cada área del conocimiento de un programa educativo, como instrumento para valorar un proceso de autoevaluación efectivo”, tiene como objetivo mostrar evidencias de las experiencias en procesos de evaluación con fines de acreditación, en las que se ha observado que existe una relación directa entre el análisis de unidades de tiempo dedicadas a un programa, con la valoración de la categoría “Plan de Estudios”, la cual es una categoría fundamental para la acreditación de un programa educativo en el área de computación. Para llevar a cabo esta investigación se consideró el universo total de programas de informática y computación evaluados por el autor con el instrumento del CONAIC en los diferentes perfiles. Se revisó el análisis hecho por cada institución en las unidades de tiempo dedicadas al programa y se hizo la correlación con la valoración de la categoría considerando el dictamen final del programa, llegando a la conclusión de que el ejercicio del análisis de estas unidades permite a los evaluadores verificar la objetividad y precisión del ejercicio de autoevaluación.
This article is entitled "The analysis units of time devoted to each area of knowledge of an educational program as an instrument for assessing a process of effective self", it aims to show evidence of experience in the process of assessment purposes accreditation, where it has been observed that there is a direct relationship between the analysis units of time devoted to a program, with an assessment of the category "Curriculum" which is a fundamental category for the accreditation of an educational program in the area of computing. To conduct this research the total universe of software and computer evaluated the instrument in different profiles CONAIC considered. The analysis by each institution in units of time devoted to the program was revised and the correlation was made with the assessment of the category considering the final opinion of the program, concluding that the exercise of these units analysis allows evaluators verify the objectivity and accuracy of the self-assessment exercise.
Rate of Return Risk pada Perbankan Syariah di Indonesia
Authors: Cipta Hendra 
Published: March 2021

The rate of return risk is one of the risks that Islamic banks in Indonesia should pay attention to. The purpose of this research is to predict the factors that affect the rate of return risk of Islamic banking in Indonesia (namely Islamic Commercial Banks and Sharia Business Units) from 2015 to 2019. The research methodology used is multiple regression with the EViews data processing application. version 9. The results of this study found that the deposit variable has a significant positive effect on the rate of return risk, while the BI-rate variable does not effect on the rate of return risk of Islamic banks in Indonesia.
Rate of return risk merupakan salah satu risiko yang harus menjadi perhatian oleh bank syariah di Indonesia. Maksud dari penelitian ini adalah untuk memprediksi faktor-faktor yang mempengaruhi rate of return risk perbankan syariah di Indonesia (yaitu Bank Umum Syariah dan Unit Usaha Syariah) dari tahun 2015 sampai dengan tahun 2019. Metodologi penelitian yang digunakan adalah regresi berganda dengan aplikasi pengolah data EViews versi 9. Hasil penelitian ini menemukan bahwa variabel deposito mempunyai pengaruh signifikan positif terhadap rate of return risk sedangkan variabel BI-rate tidak berpengaruh terhadap rate of return risk bank syariah di Indonesia.
PENERAPAN KOMBINASI METODE VIGENERE CIPHER, CAESAR CIPHER DAN SIMBOL BACA DALAM MENGAMANKAN PESAN
Authors: Hardita Veny Cahya , Sholeha Eka Wahyu 
Published: March 2021

The concept that an important information cannot be known by parties who don’t have rights can be done by making the confidentiality of data using cryptography. Safety in vigenere ciphers depends on the number of keys used, the more the number of keys, the wider the key space. While caesar cipher or often also called caesar code is a classic coding system based on simple substitution. This study uses a combination of Vigenere Cipher and Caesar Cipher algorithms so that the security of the contents of the message is protected stronger and safer so that if the message sent is tapped by someone who is not responsible then the hijacker has difficulty knowing contents of the message. So that the confidentiality and authenticity of message is up to the recipient In this study successfully implemented both methods and has an output in the form of a reading symbol, not letters.