bluuebunny/crossref_metadata_2025_split huggingface dataset:
What is the Role of Force in Correcting Scaphocephaly Through Spring-Mediated Cranial Vault Expansion for Sagittal Craniosynostosis?
Authors: Shakir Sameer , Humphries Laura S. , Lanni Michael A. , Kalmar Christopher L. , Vu Giap , Heuer Gregory , Lang Shih-Shan , Bartlett Scott P. , Taylor Jesse A. , Swanson Jordan W. 
Published: July 2021

Objectives:
Spring-mediated cranial vault expansion (SMC) may enable less invasive treatment of sagittal craniosynostosis than conventional methods. The influence of spring characteristics such as force, length, and quantity on cranial vault outcomes are not well understood. Using in vivo and ex vivo models, we evaluate the interaction between spring force, length, and quantity on correction of scaphocephalic deformity in patients undergoing SMC.

Methods:
The authors retrospectively studied subjects with isolated sagittal craniosynostosis who underwent SMC between 2011 and 2019. The primary outcome measure of in vivo analysis was head shape determined by cephalic index (CI). Ex vivo experimentation analyzed the impact of spring length, bend, and thickness on resultant force.

Results:
Eighty-nine subjects underwent SMC at median 3.4 months with median preoperative CI 69% (interquartile range: 66, 71%). Twenty-six and 63 subjects underwent SMC with 2 and 3 springs, with mean total force 20.1 and 27.6 N, respectively (P < 0.001).
Postoperative CI increased from 71% to 74% and 68% to 77% in subjects undergoing 2- and 3-spring cranioplasty at the 6-month timepoint, respectively (P < 0.001). Total spring force correlated to increased change in CI (P < 0.002). Spring length was inversely related to transverse cranial expansion at Postoperative day 1, however, directly related at 1 and 3 months (P < 0.001). Ex vivo modeling of spring length was inversely related to spring force regardless of spring number (P < 0.0001). Ex vivo analysis demonstrated greater resultant force when utilizing wider, thicker springs independent of spring arm length and degree of compression.

Conclusions:
A dynamic relationship among spring characteristics including length, bend, thickness, and quantity appear to influence SMC outcomes.
Evolution of Hematological Parameters in Patients Undergoing Orthognathic Surgery With a View to Hospital Discharge: A Prospective Study
Authors: Pereira Vinicius Balan Santos , Veras Gabriella Aguiar Rodrigues , Rocha Nelson Studart , Barbirato Davi da Silva , Neto Joaquim Celestino da Silva , Vasconcelos Belmiro Cavalcanti do Egito 
Published: July 2021

Background:
The length of hospital stays of patients undergoing orthognathic surgery depends on related local and systemic factors. Hematological changes resulting from orthognathic surgery, followed up in the postoperative period until hospital discharge, have neither yet been established for specific cases, nor for normal situations. This study aimed to describe the hemodynamic parameters of patients undergoing orthognathic surgery, considering a prediction of hospital discharge. A prospective analytical study was carried out on a sample of convenience for this purpose.

Methods:
The erythrogram, leukogram, and platelet count were assessed 24 and 72 hours after surgery and compared with preoperative values. Intraoperative volume loss was also assessed. Inferential statistical analyses were performed as analysis of variance or Friedman test, paired Wilcoxon test, Mann–Whitney test, and 2-tailed Spearman correlation.

Results:
The red blood cell count (mean ± standard deviation [median]); (4.60 ± 0.24 [4.56]), hemoglobin (12.82 ± 1.03 [12.75]), hematocrit (39.51 ± 3.47 [39.60]), and red cell distribution with (32.60 ± 0.88 [33.05]) were higher preoperatively (P < 0.001). Mean corpuscular volume (83.87 ± 5.63 [83.10]), mean corpuscular hemoglobin (27.50 ± 1.47 [28.00]), leukocytes (6262.00 ± 1448.36 [6380.00]). The volume loss varied between 463.87 and 752.13 mL (608.00 ± 144.13 [630.00]).

Conclusions:
The results of the hematological evaluations corroborate the expectation of standard discharge from the hospital, with reflected changes resulting from volume loss and intense postoperative inflammatory response, even under the anti-inflammatory pharmacological effect.
The Influence of Sex and Ancestry on Three-Dimensional Palate Shape
Authors: El Sergani Ahmed M. , Brandebura Stephanie , Padilla Carmencita , Butali Azeez , Adeyemo Wasiu L. , Valencia-Ramírez Consuelo , Muñeton Claudia P. Restrepo , Moreno Lina M. , Buxó Carmen J. , Neiswanger Katherine , Shaffer John R. , Marazita Mary L. , Weinberg Seth M. 
Published: July 2021

AbstractModern human palate shape has been reported to vary by sex and ancestry, but limitations in the methods used to quantify shape and in population coverage have led to inconsistent findings. In the present study, the authors aim to characterize the effects of sex and ancestry on normal-range three-dimensional palate shape through landmark-based morphometrics.Three-dimensional digital dental casts were obtained and landmarked from 794 adults of European (n = 429), African (n = 295), and East Asian (n = 70) ancestry. Principal component analysis was conducted to identify patterns of shape variation present in our cohort, and canonical variates analysis was performed to test for shape differences between sexes and ancestries.Principal component analysis showed that 3 principal components, explaining 76.52% of variance, linked higher palatal vault with either a relative reduction in anteroposterior or mediolateral dimensions. Canonical variates analysis showed that males had wider and shorter palates with more posteriorly located maximum vault depth than females. Individuals of African ancestry, having higher vaults with more posteriorly located maximal depths, also had wider and shorter palates, whereas individuals of European ancestry had narrower and longer palates with more anteriorly located maximum vault depths. Individuals of East Asian ancestry showed the shallowest vaults.It was found that both sex and ancestry influence palate shape, suggesting a possible genetic component underlying this variation. Additionally, our findings indicate that vault height tends to co-vary with anteroposterior or mediolateral dimensions. Further investigation of these morphological patterns may shed light on possible links to common congenital anomalies such as orofacial clefting.
The Stress Concentration and Biomechanical Properties of the Intraoral Distractors and the Extraoral Distractors Used in Treatment of Hemifacial Microsomia Patients: A Simulation Finite Element Analysis Study
Authors: El Hadidi Yasser Nabil , Askar Mohamed Gamal 
Published: July 2021

The Aim of the Study:
Finite element analysis of the stresses subjected to both the intraoral and the extraoral distractors devices used in the mandibular distraction of hemifacial microsomia patients.

Methodology:
Two models were included in the current study. The first model was an extraoral distractor and the second model was an intraoral distractor model. To generate the results in the simulated models; 2 vertical loads were applied (222.7 and 137.78 N) on the defective and normal side, respectively.

Results:
The intraoral system observed lower stress (6.85 MPa) in the mandibular bone compared to the extraoral system (13.21 MPa). The intraoral distractor had a higher stress concentration on the distractor fixing screws (352 MPa) compared to the extraoral distractor fixing pins (15 MPa). The extraoral distractor had a higher displacement effect on the mandibular bone around the pins of 263.35 μm in comparison to the intraoral distractor effect which was 77.87 μm.

Conclusions:
Internal oral distractor provides a sort of stress shielding to the distracted bone and less displacement, so it is more advisable to be used in general. The external devices are advised only in extralong distraction distance because the distractor is subjected to lower stresses compared to intraoral counterparts.
Break-through COVID-19 infection rate with Indian strain in Single-center Healthcare Workers – A real world data
Authors: Sabnis Ravindra , Patil Abhijit , Shete Nitiraj , Rastogi Arun Kumar 
Published: July 2021

AbstractIntroductionIt is observed that many healthcare workers got COVID-19 infection despite of completing both doses of Covishield vaccine. This study aimed to find real incidence of vaccine breakthrough infection.Material and methodsAll hospital employees, who were fully vaccinated were included in study. Details about their vaccine side effects, infection prior to vaccination, post vaccination infection, severity of infection, hospital and ICU admission were noted.ResultsNone encountered any significant side effects of vaccine. Of the 461 participants – 86 (18.65%) got infection average 38 days (range 14-70days) after vaccination. As per the NIH classification, out of 86, disease was mild in 69(80.2%), moderate in 10(11.62%), severe in 6(6.97%) and critical in 1(1.16%). Of these, 10(11.62%) required hospital admission. Of these 10, 2 were shifted to ICU. Of the 2, One recovered while one died. Thus mortality was 1/86(1.6%).ConclusionBreakthrough infection rate in health care workers was 18.65%. Moderate, severe or critical disease occurred in 19.7% participants even after two doses of vaccine. Mortality due to disease cannot be completely obviated due to vaccine. The vaccine was safe without any significant adverse events.
Anaesthetic Higher Specialty Training Recruitment in the United Kingdom During the COVID-19 Pandemic: A National Survey
Authors: Durrant Fionnuala , Edwardson Stuart , El-Ghazali Sally , Holt Christopher , McCrossan Roopa , Pramanik Ileena , Subramaniam Jeevakan , Wong Danny J. N. 
Published: July 2021

SummaryThe most recent ST3 Anaesthetic recruitment for posts commencing in August 2021 saw larger numbers of applicants (n = 1,056) compared to previous years, with approximately 700 applicants failing to secure an ST3 post. We surveyed 536 anaesthetic junior doctors who applied for ST3 posts during this application round with the aim of investigating their experience of the recruitment process this year (response rate 536/1,056 = 51%). Approximately 61% were not offered ST3 posts (n = 326), a similar proportion to that previously reported. We asked all respondents what their potential career plans were for the next 12 to 24 months. The majority expressed intentions to take up either CT3 top-up posts or non-training fellow posts from August 2021 (79%). Other options considered by respondents included: pursuing work abroad (17%), embarking on a career break (16%), taking up an ST3 post in intensive care medicine instead of anaesthetics (15%) and permanently leaving the medical profession (9%). A number of respondents expressed a desire to pursue training in a different medical specialty (9%). Some respondents expressed an intention to pursue further education or research (10%). A large proportion of respondents (42%) expressed a lack of confidence in being able to achieve the necessary training requirements to later apply for ST4 in August 2023. The majority of respondents reported not feeling confident in achieving GMC Specialty Registration in Anaesthesia in the future without a training number (75%), and that their wider life plans have been disrupted due to the impending time out of training (78%). We received a total of 384 free-text responses to a question asking about general concerns regarding the ST3 applications process. Sentiment analysis of these free-text responses indicated that respondents felt generally negatively about the ST3 recruitment process. Some themes that were elicited from the responses included: respondents feeling the recruitment process lacked fairness, respondents suffering burnout and negative impacts on their wellbeing, difficulties in making plans for their personal lives, and feeling undervalued and abandoned despite having made personal sacrifices to support the health service during the COVID-19 pandemic. These results suggest that junior anaesthetic doctors in the UK currently have a negative perception towards postgraduate training structures, which has been exacerbated by the COVID-19 pandemic, changes to the postgraduate training curriculum and difficulties in securing higher training posts.
Acute-stress induced change in salience network coupling prospectively predicts post-trauma symptom-development
Authors: Zhang Wei , Kaldewaij Reinoud , Hashemi Mahur M. , Koch Saskia B.J. , Smit Annika , van Ast Vanessa , Beckmann Christian F. , Klumpers Floris , Roelofs Karin 
Published: July 2021

AbstractSubstantial individual differences exist in how acute stress affects large-scale neurocognitive networks, including Salience (SN), Default Mode (DMN) and Central Executive Networks (CEN). Changes in the connectivity strength of these network upon acute stress may predict vulnerability to long-term stress effects, which can only be tested in prospective longitudinal studies. Using such longitudinal design, we investigated whether the magnitude of acute-stress induced functional connectivity changes (delta-FC) predicts the development of posttraumatic stress disorder (PTSD) symptoms in a relatively resilient group of young police students that are known to be at high risk for trauma-exposure.Using resting-state fMRI, we measured acute-stress induced delta-FC in 190 police recruits before (baseline) and after trauma exposure during repeated emergency aid services (16-month follow-up). Delta-FC was then linked to the changes in perceived stress levels (PSS) and post-traumatic stress symptoms (PCL and CAPS).Weakened connectivity between the SN and DMN core regions upon acute stress induction at baseline predicted longitudinal increases in perceived stress level but not of post-traumatic stress symptoms, whereas increased coupling between the overall SN and anterior cerebellum was observed in participants with higher clinician-rated PTSD symptoms, particularly intrusion levels. All effects remained significant when controlling for trauma exposure-levels and cortisol stress-reactivity. Neither hormonal nor subjective measures exerted similar predictive or acquired effects.The reconfiguration of large-scale neural networks upon acute stress induction is relevant for assessing and detecting risk and resilience factors for PTSD. This study highlights the SN connectivity-changes as a potential marker for trauma-related symptom-development, which is sensitive even in a relatively resilient sample.
Critical Role of the Subways in the Initial Spread of SARS-CoV-2 in New York City
Authors: Harris Jeffrey E. 
Published: July 2021

AbstractWe studied the possible role of the subways in the spread of SARS-CoV-2 in New York City during late February and March 2020. Data on cases and hospitalizations, along with phylogenetic analyses of viral isolates, demonstrate rapid community transmission throughout all five boroughs within days. The near collapse of subway ridership during the second week of March was followed within 1-2 weeks by the flattening of COVID-19 incidence curve. We observed persistently high entry into stations located along the subway line serving a principal hotspot of infection in Queens. We used smartphone tracking data to estimate the volume of subway visits originating from each zip code tabulation area (ZCTA). Across ZCTAs, the estimated volume of subway visits on March 16 was strongly predictive of subsequent COVID-19 incidence during April 1-8. In a spatial analysis, we distinguished between the conventional notion of geographic contiguity and a novel notion of contiguity along subway lines. We found that the March 16 subway-visit volume in subway-contiguous ZCTAs had an increasing effect on COVID-19 incidence during April 1-8 as we enlarged the radius of influence up to 5 connected subway stops. By contrast, the March 31 cumulative incidence of COVID-19 in geographically-contiguous ZCTAs had an increasing effect on subsequent COVID-19 incidence as we expanded the radius up to 3 connected ZCTAs. The combined evidence points to the initial citywide dissemination of SARS-CoV-2 via a subway-based network, followed by percolation of new infections within local hotspots.
Fear of COVID-19 among nurses in mobile COVID-19 testing units in Greece
Authors: Galanis Petros , Petrogianni Emmanouela , Vraka Irene , Konstantakopoulou Olympia , Siskou Olga , Bilali Angeliki , Kaitelidou Daphne 
Published: July 2021

AbstractBackgroundMobile COVID-19 testing units are used worldwide to test quickly and easily individuals for COVID-19.AimTo assess the level of fear of COVID-19 among nurses in mobile COVID-19 testing units and compare it with demographic characteristics.MethodsA cross-sectional study was conducted during November and December 2020. Study population included 57 nurses working in mobile COVID-19 testing units in Attica, Greece. We collected demographic data from the nurses, i.e. gender, age, marital status, children, living status (alone or with others), clinical experience, and chronic disease. We used the fear of COVID-19 scale to measure fear of the COVID-19 pandemic.ResultsThe mean score on the fear of COVID-19 scale was 14.3. Among nurses, 31.6% experienced elevated fear indicative of presence of anxiety symptoms, while the respective percentages for health anxiety and post-traumatic stress symptomatology were 22.8% and 17.5%. Fear of COVID-19 was not affected by demographic variables. However, fear was higher in females, nurses who had children and nurses who lived with others. Increased clinical experience was related with decreased fear.ConclusionsCreating a secure work environment for nurses in these units could decrease fear of COVID-19 and increase work performance.
Visual perturbation of balance suggests impaired neuromuscular stability but intact visuo-motor control in Parkinson’s disease
Authors: Engel David , Student Justus , Schwenk Jakob C.B. , Morris Adam P. , Waldthaler Josefine , Timmermann Lars , Bremmer Frank 
Published: July 2021

AbstractPostural instability marks one of the most disabling features of Parkinson’s disease (PD), but only reveals itself after affected brain areas have already been significantly damaged. Thus, there is a need to detect deviations in balance and postural control before visible symptoms occur. In this study, we visually perturbed balance in the anterior-posterior direction using sinusoidal oscillations of a moving room in virtual reality at different frequencies. We tested three groups: individuals with PD under dopaminergic medication, an age-matched control group, and a group of young healthy adults. We tracked their centre of pressure and their full-body motion. We investigated sway amplitudes and applied newly introduced phase-locking analyses to investigate responses across participants’ bodies. Patients exhibited significantly higher sway amplitudes as compared to the control subjects. However, their sway was phase-locked to the visual motion like that of age-matched and young healthy adults. Furthermore, all groups successfully compensated for the visual perturbation by – most likely reflexively - phase-locking their sway to the stimulus. As frequency of the perturbation increased, distribution of phase-locking (PL) across the body revealed a shift of the highest PL-values from the upper body towards the hip-region for young healthy adults, which could not be observed in patients and elderly healthy adults. Our findings suggest an impaired neuromuscular stability, but intact visuomotor processing in early stages of PD, while less flexibility to adapt postural strategy to different perturbations revealed to be an effect of age rather than disease.New & NoteworthyA better understanding of visuomotor control in Parkinson’s disease (PD) potentially serves as a tool for earlier diagnosis, which is crucial for improving patient’s quality of life. In our study, we assess body sway responses to visual perturbations of the balance control system in patients with early-to-mid stage PD, using motion tracking along with recently established phase-locking techniques. Our findings suggest patients at this stage to have an impaired muscular stability but intact visuomotor control.
A case-control study of autoimmune AEFIs following COVID-19 vaccination reported to VAERS
Authors: von Csefalvay Chris 
Published: July 2021

AbstractAutoimmune adverse effects following immunisation (AEFIs) are widely regarded as a chief concern driving vaccine hesitancy. This case-control study seeks to shed light on the true risk of autoimmune AEFIs associated with the COVID-19 vaccine through a case-control analysis of VAERS reports. Reports of autoimmune aetiology were matched with reports of non-autoimmune controls. Statistical analysis reveals that the safety profile of COVID-19 vaccines with regard to autoimmune AEFIs is highly favourable. In particular, neuroautoimmune AEFIs have statistically significant reporting odds ratios below unity (Guillain-Barre syndrome: 0.35, multiple sclerosis: 0.70, transverse myelitis: 0.79), indicating a reduced association of reports of these conditions with the COVID-19 vaccine versus other vaccines. Only three autoimmune aetiologies exceed a ROR of 2.0 and thus present a potential signal. Of these, myasthenia gravis (ROR = 3.90, p < 0.001, 95% CI: 2.63-5.80) may be the result of epidemiological confounding factors not sufficiently controlled by matching, as the population most likely to develop myasthenia gravis was strongly prioritised in the COVID-19 vaccine’s initial rollout. Immune thrombocytopaenia (ROR = 26.83, p < 0.001, 95% CI: 16.93-42.54) is a clear safety signal, confirming a large number of case reports and studies that indicate a risk of immune thrombocytopaenic events following the COVID-19 vaccine. The lone strong safety signal of immune thrombocytopaenia notwithstanding, this study attests to the safety of the COVID-19 vaccine where autoimmune conditions are concerned. Through quantifying the risk of autoimmune disorders associated with COVID-19 vaccination, this study contributes to a growing body of evidence supporting the safety of such vaccines.