bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cold scissors ploughing technique versus electrosurgical excision for hysteroscopic adhesiolysis: a multicenter randomized controlled trial
Authors: Liu Yichun , Xie Xiaoshi , Xue Pingping , Yuan Fang , Qi Yinghua , Wang Hui , Wang Ping , Lv Guanjun , Song Kejuan , Yang Zongzhi , Zhang Ya-Nan , Yan Lei 
Published: December 2024

Intrauterine adhesions (IUAs) may lead to abnormal menstruation, infertility, and pregnancy-related complications. Hysteroscopic separation is the gold standard treatment for IUA and can be performed using a variety of instruments and methods, including cold scissors and electrotomy. However, it is unclear which method is more effective for relieving IUA, restoring uterine anatomy, and improving the pregnancy rate in women of childbearing age. This multicenter prospective randomized clinical trial included 218 women aged 20–40 years who were treated for IUA between 1 March 2021 and 30 June 2022 and followed for 1.5 years. The women were randomly assigned to a cold scissors group (n = 109) or electrosurgical excision group (n = 109). Second-look hysteroscopy was performed in all patients within 3–10 days after the end of the first postoperative menstrual period. The primary outcome was the change in American Fertility Society score. Secondary outcomes included postoperative menstrual blood loss, the recurrence rate, and the reproductive outcome. There was no significant difference in the curative effect of hysteroscopic adhesiolysis between the cold scissors group and the electrosurgical excision group (5 [interquartile range, 4–6] vs. 5 [interquartile range, 4–6], P = 0.729) or in the postoperative recurrence rate (27.5% vs. 30.6%, relative risk 0.901, 95% confidence interval 0.594–1.366, P = 0.623) or pregnancy outcomes between the two groups. Postoperative menstrual blood loss was significantly greater in the cold scissors group than in the electrosurgical excision group (65.1% vs. 48.1%, P = 0.029). The treatment cost was significantly lower in the cold scissors group (P < 0.001). In conclusion, hysteroscopic adhesiolysis using cold scissors does not differ significantly from electrosurgery in terms of treatment efficacy, recurrence rate, pregnancy rate, or pregnancy-related complications in patients with IUA who have normal ovarian reserve and an endometrial thickness of ≥6 mm before ovulation. The cold scissors ploughing technique can increase menstrual blood loss and is a cost-effective procedure.
Efficacy of laparoscopic parenchyma-sparing hepatectomy using augmented reality navigation combined with fluorescence imaging for colorectal liver metastases: a retrospective cohort study using inverse probability treatment weighting analysis
Authors: Zeng Xiaojun , Li Xinci , Lin Wenjun , Wang Junfeng , Fang Chihua , Pan Mingxin , Tao Haisu , Yang Jian 
Published: December 2024

Background:
Laparoscopic parenchyma-sparing hepatectomy (PSH) is an effective treatment for colorectal liver metastases (CRLMs), but ensuring the safety and radicality of the procedure, particularly for deep-seated tumors, remains challenging. Surgical navigation technologies such as augmented reality navigation (ARN) and indocyanine green fluorescence imaging (ICG-FI) are increasingly utilized to guide surgery, yet their efficacy for CRLMs is unclear. This study aims to evaluate the short-term and long-term outcomes of ARN combined with ICG-FI-guided (ARN-FI) laparoscopic PSH for CRLMs.

Methods:
Between January 2020 and December 2022, 89 consecutive patients who underwent laparoscopic PSH for CRLMs were included in the study. Patients were divided into an ARN-FI group (n = 38) and a non-ARN-FI group (n = 51) based on the use of ARN-FI. Inverse probability treatment weighting (IPTW) was used to balance baseline characteristics and minimize potential selection bias. Short-term and long-term outcomes were compared between the two groups. Cox regression analysis was conducted to identify risk factors associated with recurrence-free survival (RFS) and hepatic RFS.

Results:
After IPTW, there were 87 patients in the ARN-FI group and 89 patients in the non-ARN-FI group. Shorter parenchymal transection time, postoperative hospital stays, and wider margins were observed in the ARN-FI group. There was no significant difference in RFS or hepatic RFS between the groups. Mutant KRAS status was an independent risk factor for both RFS and hepatic RFS, while tumor diameter ≥ 5 cm and deep-seated location were risk factors for hepatic RFS. In the subgroup analysis of deep-seated tumors, the ARN-FI group also showed less intraoperative blood loss, a lower rate of strategy change, shorter postoperative recovery times, a higher R0 resection rate, and improved RFS and hepatic RFS.

Conclusions:
In laparoscopic PSH for CRLMs, ARN-FI may improve surgical efficiency and accuracy. Especially for deep-seated tumors, it has the potential to reduce blood loss and attain higher R0 resection rates.
Systematic analysis of sugammadex-related adverse drug reaction signals using FAERS database
Authors: Liu Hongtao , Yang Qianqian , Li Zhaoyu , Yan Su , Ming Shaopeng 
Published: December 2024

Background:
With the clinical integration of sugammadex, a selective relaxant-binding agent, the approach to reversing neuromuscular blockade is revolutionized. Despite its efficacy, sugammadex’s adverse reactions range from mild symptoms to severe cases, including anaphylaxis and coagulopathy. Assessing the nature of these reactions using the Food and Drug Administration’s Adverse Event Reporting System (FAERS) database is vital for safe anesthetic practice. This study aimed to analyze and categorize the adverse drug events (ADEs) related to sugammadex reported in the FAERS database and evaluate the potential safety signals since its market entry.

Materials and methods:
This systematic analysis study extracted and filtered FAERS data pertinent to sugammadex from its introduction in 2008 to the last quarter of 2023 and employed standardized MedDRA terminologies for ADE re-encoding. The Reporting Odds Ratio (ROR) method analyzed ADE signal strength, identifying significant cardiovascular, allergic, and neurological signals.

Results:
From 1505 patient reports totaling 3562 ADEs, prominent adverse reaction signals were detected for respiratory and cardiovascular systems and severe allergic and neurological effects. Specific signals, including laryngospasm, bronchospasm, and Disseminated Intravascular Coagulation (DIC), among others, were highlighted and necessitated urgent clinical attention.

Conclusions:
Sugammadex is associated with a spectrum of adverse reactions, some of which demand increased clinical surveillance, particularly in older and pediatric populations. The significance of allergic reactions, airway spasms, and coagulation events indicates the need for precise risk assessment and vigilant monitoring during clinical use.
Associations of osteoarthritis with risk of future fracture events: prospective study in UK Biobank
Authors: Wang Ping , Tang Zijun , Lin Xiaoyu , Shao Wenkai , Wang Bo , Li Zilin , Lv Xiao , Liu Gang , Feng Yong 
Published: December 2024

Background:
Researchers have long been interested in the potential relationship between osteoarthritis (OA), falls, and fractures; however, the evidence supporting this relationship has been conflicting. This study aimed to investigate the association between osteoarthritis and future fracture events.

Materials and methods:
This study was designed as a prospective cohort study. We recruited a total of 440 476 individuals from the UK Biobank to investigate the impact of OA on the incidence of fracture. Among the total population, there were 54 581 participants diagnosed with OA. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs).

Results:
A total of 26 083 fracture events were documented over a median follow-up period of 13.5 years. After multivariable adjustment, participants with osteoarthritis had an HR (95% CI) of 1.11 (1.08, 1.15) for future fracture events compared to participants without osteoarthritis (P < 0.0001). Falls explained 16.34% of the association between osteoarthritis and fracture events and 14.15% of the association between knee osteoarthritis and fracture events. The association was not substantially altered across the series of sensitivity analyses.

Conclusion:
Osteoarthritis was associated with a greater risk of future fracture events. This finding highlights the importance of preventing future fracture events in people with osteoarthritis.
The timing of surgical interventions following the implantation of coronary drug-eluting stents in patients undergoing gastrointestinal cancer surgery: a multicenter retrospective cohort study
Authors: Xu Ziyao , Lai Yingying , Zhou Yan , Qin Lipeng , Hao Xinyu , Li Tian , Gao Lei , Wang Xinxin 
Published: December 2024

Aim:
We aim to investigate the optimal timing for surgical interventions to maximize patient benefit.

Background:
The guidelines recommending a minimum deferral of 6 months for non-cardiac surgeries following drug-eluting stent percutaneous coronary intervention (DES-PCI) do not adequately address the requirements for individuals undergoing gastrointestinal cancer surgery (GCS).

Methods:
The study encompassed 2501 patients treated from January 2017 to December 2021, all of whom underwent GCS within 1 year after DES-PCI. We conducted an analysis by comparing the occurrence of major adverse cardiovascular events (MACEs) within 30 days post-surgery at different time points.

Results:
This study enrolled a total of 2501 participants with meticulously recorded data who underwent DES-PCI and subsequently underwent GCS within 1 year post-implantation. The incidence rate of MACEs is 14.2%, including MI (5.1%), HF (5.8%), IS (3.2%), and cardiac death (0.2%), across all patients in this study. The threshold probability was determined using the Youden Index, resulting in a value of 0.320, corresponding to a “time-to-surgery value” of 87. Significant statistical differences were observed in the occurrence rates of MACEs for adjacent time intervals at 30 days (P < 0.001), 90 days (P < 0.009), and 180 days (P < 0.001).

Conclusions:
The timing of surgical intervention following DES-PCI significantly influences the occurrence of MACEs at 1, 3, and 6 months. GCS may be appropriately advanced within the 6-month timeframe, but with the exception of emergency, efforts should be made to defer them beyond the initial month.
Rare Inherited Coagulation Deficiencies: A Single-center Study
Authors: Terzi Özlem , Hatipoğlu Sadik Sami 
Published: December 2024

Background:
Rare factor deficiency (RFD) is characterized by a deficiency of factor (F)I, FII, FV, FVII, FX, FXI, FXII, FXIII, or a combined deficiency of FV+FVIII or vitamin K-dependent factors. The prevalence of RFD ranges from 1/1,000,000 to 3,000,000. Combined deficiencies of vitamin K-related factors have been described in 30 families worldwide, and these patients can present with a wide range of clinical symptoms, from mucocutaneous bleeding to life-threatening symptoms such as central nervous system and gastrointestinal bleeding.

Objective:
This study aimed to contribute to the literature on RFD.

Material and Methods:
This retrospective study analyzed data from 43 children with RFD.

Results:
The most common factor deficiencies were FVII (n=13); whereas the other deficiencies were FI (n=1), FV (n=2), FV+FVIII (n=2), FX (n=6), FXI (n=5), FXII (n=9), FXIII (n=3), and vitamin K-dependent combined factor deficiency (n=2). Acute and severe bleeding was controlled by treatment in 6 patients, and 12 patients with recurrent bleeding symptoms received prophylaxis. RFDs were more common in regions with high rates of consanguineous marriage, and in our study, 16 (16/43) of the cases were found to have consanguineous marriages between parents.

Conclusions:
It is important to improve genetic counseling and access to testing for family members with RFD due to autosomal recessive inheritance. Delays in diagnosis and treatment and lack of adequate prevention are important risk factors for life-threatening bleeding.
The Application of the NOSES System to Treat Cheek Squamous Cell Carcinoma
Authors: Wang Wei-Qi , Mu Si-Qi , Na Si-Jia , Ding Ming-Chao , Chen Jie , Zhang Xi , Wei Jian-Hua 
Published: December 2024

Purpose:
Oral squamous cell carcinoma is one of the most common types of cancer in the head and neck. Squamous cell carcinoma of the buccal mucosa is an important part of it. The traditional surgical method leads to great injury and is accompanied by unacceptable scars. Previous improvements have been carried out in a single part. Natural orifice specimen extraction surgery (NOSES) system could perform “scarless surgery” and reduce complications. This technique was usually used for transvaginal or transanal specimen retrieval. There is great potential for oral and maxillofacial applications, especially in the field of oral and maxillofacial surgery. We combine the 2 to achieve better surgical results.

Methods:
The authors applied the NOSES system in the radical operation of buccal mucosa squamous cell carcinoma. Through FACE-LIFT incision, with the help of indocyanine green (ICG) and microscope, they successfully cured buccal mucosa squamous cell carcinoma.

Results:
The patient was cured, and there was no recurrence after 1 year of follow-up. The incision is hidden, and the damage is small. The number of harvested lymph nodes in the pathologic examination was 1/18.

Conclusions:
The application of the NOSES system in maxillofacial surgery has very obvious advantages. The surgical procedures follow the principles of aseptic and tumor-free techniques, making the tumor en-block dissection. For stage 1 patients, this scheme not only ensures the radical cure of the tumor but also improves the detection rate of lymph nodes and ensures the patients' appearance. For doctors, this program is easy to operate and learn and can reduce the peer gap.
Profileplasty: Comprehensive Facial Profile Management Algorithm Based on 426 Patients
Authors: Reategui Alvaro , Jazayeri Hossein , Mier Alexa , Peck Connor J. , Phillips Sarah , Lopez Joseph , Steinbacher Derek 
Published: December 2024

Objective:
Profileplasty traditionally involves improving a nasal hump or an underprojected chin. However, this procedure can correct other facial defects like saddle nose or prognathism. To establish the best overall profile, the nose, the midface, and the chin should be considered altogether. This study aimed to describe typical facial profiles and propose an algorithm for targeted correction.

Methods:
Patients who underwent rhinoplasty, with or without other facial procedures performed by the senior author were reviewed. Patients with pre and postoperative photographs and clinical follow-up were included. Images were analyzed using Goode and Steiner analyses and E and S lines to assess and categorize nasal and facial profiles. A treatment algorithm for each sub-group was proposed based on expert opinion. Adherence to the algorithm was validated by reviewing patients’ charts.

Results:
A total of 426 rhinoplasty patients were included, with 72 also undergoing orthognathic surgery, including genioplasty. There were 2 general groups of patients: (1) poor nasal profile with a balanced facial profile and (2) poor nasal profile with an unbalanced facial profile. Group 1 included (1a) prominent (n = 298) or (1b) flat (n = 56) nasal dorsum. Group 2 included (2a) convex profile (n = 38), (2b) concave profile (n = 32), and (2c) “pseudo-dorsum” (n = 2). Proposed treatments for group 1 involved balancing the nasal dorsum and nasofrontal angle, whereas group 2 involved modifying the nasal dorsum and repositioning the maxilla/mandible. Of patients, 98.6% followed the proposed treatment algorithm.

Conclusion:
This study describes common profile patterns and highlights a profileplasty algorithm that offers systematic treatment planning for most patients.
Fitness drivers of division of labor in vertebrates
Authors: García-Ruiz Irene , Rubenstein Dustin 
Published: December 2024

AbstractAlthough division of labor as a means to increase productivity is a common feature in animal social groups, most previous studies have focused almost exclusively on eusocial insects with extreme task partitioning. Empirical evidence of division of labor in vertebrates is scarce, largely because we lack a theoretical framework to explore the conditions under which division of labor is likely to evolve. By explicitly considering alternative helping tasks with varying fitness costs, we model how individual decisions on task specialization may influence the emergence of division of labor under both direct and indirect fitness benefits. Surprisingly, we find that direct survival benefits of living in larger groups are the primary force driving the evolution of cooperation to enhance group productivity, and that indirect fitness benefits derived from related group members are only a non-essential facilitator of more stable forms of division of labor. In addition, we find that division of labor is favored by increasingly harsh environments. Ultimately, our model not only makes key predictions that are consistent with existing empirical data, but also proposes novel avenues for new empirical work in vertebrate and invertebrate systems alike.
G protein Inactivation as a Mechanism for Addiction Treatment
Authors: Neiswanger Carlie , Ruiz Micaela V. , Kimball Kandace , Lee Justin D. , Land Benjamin , Berndt Andre , Chavkin Charles 
Published: December 2024

AbstractThe endogenous dynorphin/kappa opioid receptor (KOR) system in the brain mediates the dysphoric effects of stress, and KOR antagonists may have therapeutic potential for the treatment of drug addiction, depression, and psychosis. One class of KOR antagonists, the long-acting norBNI-like antagonists, have been suggested to act by causing KOR inactivation through a cJun-kinase mechanism rather than by competitive inhibition. In this study, we screened for other opioid ligands that might produce norBNI-like KOR inactivation and found that nalfurafine (a G-biased KOR agonist) and nalmefene (a KOR partial agonist) also produce long-lasting KOR inactivation. Neither nalfurafine nor nalmefene are completely selective KOR ligands, but KOR inactivation was observed at doses 10-100 fold lower than necessary for mu opioid receptor actions. Daily microdosing with nalfurafine or nalmefene blocked KORs responsible for antinociceptive effects, blocked KORs mediating stress-induced aversion, and mitigated the aversion during acute and protracted withdrawal in fentanyl-dependent mice. Both nalfurafine and nalmefene have long histories of safety and use in humans and could potentially be repurposed for the treatment of dynorphin-mediated stress disorders.
Individual Alpha Frequency Predicts the Sensitivity of Time Perception
Authors: Morrow Audrey , Wilson Montana , Geller-Montague Michaela , Soldano Sara , Hajidamji Sabah , Samaha Jason 
Published: December 2024

AbstractA growing body of research links individual differences in the frequency of alpha-band oscillations to temporal aspects of perception. However, whether the human alpha rhythm is a correlate of time perception itself has remained controversial. This multi-day study combined EEG with multiple duration estimation and discrimination tasks in order to evaluate whether individual alpha frequency (IAF) is associated with sensitivity or bias in judging visual durations across a range of peri-second durations (spanning 1200 to 100ms). In a temporal estimation task, participants (n = 55) reported the duration of a single stimulus between 300-1200ms. In a temporal discrimination task, participants reported which of two stimuli was longer: a standard (100, 600, or 1200ms) or comparison (50-150% of the standard). Stimuli also varied in whether their luminance was static or dynamic (varying randomly over time). We found that IAF was significantly related to the variance of duration estimates, a measure of precision (or sensitivity), but not average duration estimates, a measure of bias. Further supporting this relationship, psychometric function slopes obtained from independent duration discrimination tasks were correlated with IAF, particularly for the static stimulus conditions. These effects were largely consistent across the range of stimulus durations tested and held when controlling for participant age. Taken together, these results suggest that IAF plays a role in shaping individual differences in the sensitivity of time perception. However, we did not observe effects of spontaneous fluctuations in single-trial alpha frequency, suggesting the effect is primarily observable at the cross-subject level.Significance StatementBrain waves in the 8-13 Hz range, known as alpha waves, have long been hypothesized to modulate our perception of time, yet the evidence remains unclear. This study investigates the relationship between an individual’s alpha frequency (IAF) and temporal sensitivity using a wide range of time perception tasks and stimulus durations to address gaps in the literature. We demonstrate that IAF is significantly associated with the precision of duration estimates and sensitivity in duration discrimination, particularly for static unchanging stimuli. These findings provide novel evidence that IAF shapes individual differences in time perception, emphasizing its role as a neural marker of temporal sensitivity.
Why did you use that test? Exploring speech-language pathologists clinical decision-making in bilingual language and literacy assessment
Authors: Wood Emily , Kika Mariya , Daub Olivia , Molnar Monika 
Published: December 2024

AbstractPurposeOur overarching goal is to advance our understanding of clinical decision-making processes in bilingual language and literacy assessment. When evaluating bilingual children, speech-language pathologists (SLPs) use static norm-referenced assessments (SAs) developed for English monolinguals more frequently than less biased dynamic assessments (DAs). To date, no research has considered why SLPs use SAs over DAs or examined SLPs’ conceptualization of validity beyond knowledge of psychometrics. In this study we explore factors that affect SLPs’ choice and use of assessments and how clinicians conceptualize and employ validity through the lens of modern validity frameworks.MethodCanadian SLPs (n=21) participated in semi-structured interviews, using a guide informed by the Theoretical Domains frameworks and Kane’s Validity framework. Reflexive thematic analysis was used to generate themes.ResultsClinicians rarely report using “dynamic assessment” but did “assess dynamically” by incorporating teaching in testing. When assessing oral language, SLPs acknowledged that using SAs with bilinguals may be inappropriate, but that they continue to do primarily because scores from these measures are necessary for diagnosis and accessing services. To contend with this friction between clinical beliefs and workplace requirements, most SLPs report caveats alongside SA scores SAs to contextualize findings. Though individual clinical knowledge of psychometrics and validity in assessment varies, systemic issues play a key role in perpetuating current assessment practices with bilinguals. Finally, bilingual literacy assessment practices differ. Clinicians use a wider variety of assessments and rely less on scores to achieve desired outcomes for students.ConclusionClinical decision-making in bilingual language and literacy assessment is influenced by both individual and contextual factors. Accordingly, efforts to shift practice patterns cannot solely focus on individual clinical knowledge but must also examine and address these systemic issues.