bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between severity of COVID-19 symptoms and habitual food intake in adult outpatients
Authors: Salazar-Robles Elihud , Kalantar-Zadeh Kourosh , Badillo Humberto , Calderón-Juárez Martín , García-Bárcenas Cesar Alberto , Ledesma-Pérez Pedro Daniel , Lerma Abel , Lerma Claudia 
Published: November 2021

ObjectiveTo evaluate the association between habitual frequency of food intake of certain food groups during the COVID-19 pandemic and manifestations of COVID-19 symptoms in adult outpatients with suspected SARS-CoV-2 infection.DesignWe included 236 patients who attended an outpatient clinic for suspected COVID-19 evaluation. Severity of symptoms, habitual food intake frequency, demographics and Bristol chart scores were obtained before diagnostic confirmation with real-time reverse transcriptase PCR using nasopharyngeal swab.ResultsThe results of the COVID-19 diagnostic tests were positive for 103 patients (44%) and negative for 133 patients (56%). In the SARS-CoV-2-positive group, symptom severity scores had significant negative correlations with habitual intake frequency of specific food groups. Multivariate binary logistic regression analysis adjusted for age, sex and occupation confirmed that SARS-CoV-2-positive patients showed a significant negative association between having higher symptom severity and the habitual intake frequency of ‘legumes’ and ‘grains, bread and cereals’.ConclusionsIncrease in habitual frequency of intake of ‘legumes’, and ‘grains, bread and cereals’ food groups decreased overall symptom severity in patients with COVID-19. This study provides a framework for designing a protective diet during the COVID-19 pandemic and also establishes a hypothesis of using a diet-based intervention in the management of SARS-CoV-2 infection, which may be explored in future studies.
Effect of refrigeration on the collagen and texture characteristics of yak meat
Authors: Li Shengsheng , Zhang Yawei , Liu Shujie 
Published: November 2021

To investigate the effect of refrigeration on the collagen and texture characteristics of yak meat, the changes in collagen content, solubility, shear force, hardness, cohesiveness, springiness, gumminess, and chewiness of yak meat at 4 ± 1 °C were measured. The results showed that the contents and solubility of collagen in yak meat significantly decreased (P < 0.05). The myofibrillar fragmentation index of yak meat significantly increased (P < 0.05). The shear force, hardness, cohesiveness, springiness, gumminess, and chewiness of yak meat significantly decreased (P < 0.05). Correlation analysis and histological structure analysis confirmed that myofibrillar fragmentation and collagen characteristics significantly affected the formation of yak meat texture during refrigeration. After 5 d of refrigerated storage, yak meat has a higher quality. The results provide a theoretical basis and data to support the deep processing and quality control of yak meat.
Effect of dietary folic acid and energy density on immune response, gut morphology, and oxidative status in blood and breast muscle of broiler chickens
Authors: Akinyemi Fisayo T. , Adewole Deborah I. 
Published: November 2021

Folic acid (FA) plays essential roles in many metabolic functions and has been reported to have antioxidant effects. Therefore, dietary supplementation with high levels of FA may improve gut health and prevent potential oxidative stress caused by feeding a high energy density diet to broiler chickens. Broiler chickens were assigned into eight treatments, consisting of either a normal energy (NE) or high energy (HE) density diet, and four FA levels (2.2, 5, 10, and 15 ppm). Data were analyzed by SAS 16 GLM procedure. Birds-fed HE diets had increased (P < 0.05) plasma concentrations of calcium and albumin but reduced (P < 0.005) weights of ceca and bursa compared with those fed NE diets. Dietary supplementation with 10 ppm FA significantly increased (P < 0.05) birds’ heart weight and bile acid concentration. Folic acid and energy density interactions were significant for jejunal villus height (VH; P = 0.0226), villus width (VW; P < 0.0001), and crypt depth (CD; P = 0.0332). Among the NE group, birds fed 5–15 ppm FA had reduced (P < .0001) VW, while in the HE groups, 15 ppm FA supplementation resulted in an increased jejunal VH (P = 0.0317) compared with other treatments. In conclusion, dietary supplementation with increased levels of FA in HE diets could be beneficial for the intestinal health of broiler chickens.
The timing of spring warming shapes reproductive effort in a warm-water fish: the role of mismatches between hepatic and gonadal processes
Authors: Fernandes Timothy J. , Shuter Brian J. , Ihssen Peter E. , McMeans Bailey C. 
Published: November 2021

Temperate zone winters are experiencing greater rates of warming relative to other seasons and latitudinal regions globally. Spring-spawning fishes native to northern environments rely on both increasing temperature and lengthening photoperiod to cue reproduction and may thus be particularly sensitive to rapid warming earlier in the year while day lengths remain short. We investigated the reproductive response of pumpkinseed sunfish (Lepomis gibbosus) to spring warming commencing at a range of day lengths (9–15 hours), corresponding to various calendar days (10 January – 22 May). In both the laboratory and field, both male and female fish that experienced early warming while day lengths were <11 hours (1) failed to initiate reproductive preparation in the liver before gonad development began and (2) had reduced reproductive allocation. Analysis of published data on temperate fishes suggested that liver development prior to gonad development is widespread across warm-, cool-, and cold-water thermal guilds, though the precise phenology of liver relative to gonad development appears to vary widely among species. Together, our results point toward dampened reproductive preparation as a novel mechanism mediating reduced reproductive output in both warm- and cool-water fish following earlier spring warming.
Accretion onto a quintessence contaminated rotating black hole: violating the lower limit for eta over s
Authors: Biswas Ritabrata , Biswas Promila , Roy Parthajit 
Published: November 2021

AbstractViscous accretion flow around a rotating supermassive black hole sitting in a quintessence tub is studied in this article. To introduce such a dark energy contaminated black hole’s gravitational force, a new pseudo-Newtonian potential is used. This pseudo-Newtonian force can be calculated if we know the distance from the black hole’s center, spin of the black hole and equation of state of the quintessence inside which the black hole is considered to lie. This force helps us to avoid complicated nonlinearity of general relativistic field equations. Transonic, viscous, continuous and Keplerian flow is assumed to take place. Fluid speed, sonic speed profile and specific angular momentum to Keplerian angular momentum ratio are found out for different values of spin parameter and quintessence parameter. Density variation is built and tallied with observations. Shear viscosity to entropy density ratio is constructed for our model and a comparison with theoretical lower limit is done.
Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function
Authors: Gan Lu , Liu Demin , Xie Dina , Bond Lau Wayne , Liu Jing , Christopher Theodore A. , Lopez Bernard , Liu Lian , Hu Hang , Yao Peng , He Yarong , Gao Erhe , Koch Walter J. , Zhao Jianli , Ma Xin-Liang , Cao Yu , Wang Yajing 
Published: November 2021

Background:
Patients with acute myocardial infarction suffer systemic metabolic dysfunction via incompletely understood mechanisms. Adipocytes play critical role in metabolic homeostasis. The impact of acute myocardial infarction upon adipocyte function is unclear. Small extracellular vesicles (sEVs) critically contribute to organ-organ communication. Whether and how small extracellular vesicle mediate post-MI cardiomyocyte/adipocyte communication remain unknown.

Methods:

Plasma sEVs were isolated from sham control (Pla-sEV
Sham
) or 3 hours after myocardial ischemia/reperfusion (Pla-sEV
MI/R
) and incubated with adipocytes for 24 hours. Compared with Pla-sEV
Sham
, Pla-sEV
MI/R
significantly altered expression of genes known to be important in adipocyte function, including a well-known metabolic regulatory/cardioprotective adipokine, APN (adiponectin). Pla-sEV
MI/R
activated 2 (PERK-CHOP and ATF6 [transcription factor 6]-EDEM [ER degradation enhancing alpha-mannosidase like protein 1] pathways) of the 3 endoplasmic reticulum (ER) stress pathways in adipocytes. These pathological alterations were also observed in adipocytes treated with sEVs isolated from adult cardiomyocytes subjected to in vivo myocardial ischemia/reperfusion (MI/R) (Myo-sEV
MI/R
). Bioinformatic/RT-qPCR analysis demonstrates that the members of miR-23-27-24 cluster are significantly increased in Pla-sEV
MI/R
, Myo-sEV
MI/R
, and adipose tissue of MI/R animals. Administration of cardiomyocyte-specific miR-23-27-24 sponges abolished adipocyte miR-23-27-24 elevation in MI/R animals, supporting the cardiomyocyte origin of adipocyte miR-23-27-24 cluster. In similar fashion to Myo-sEV
MI/R
, a miR-27a mimic activated PERK-CHOP and ATF6-EDEM-mediated ER stress. Conversely, a miR-27a inhibitor significantly attenuated Myo-sEV
MI/R
-induced ER stress and restored APN production.

Results:

An unbiased approach identified EDEM3 (ER degradation enhancing alpha-mannosidase like protein 3) as a novel downstream target of miR-27a. Adipocyte EDEM3 deficiency phenocopied multiple pathological alterations caused by Myo-sEV
MI/R
, whereas EDEM3 overexpression attenuated Myo-sEV
MI/R
-resulted ER stress. Finally, administration of GW4869 or cardiomyocyte-specific miR-23-27-24 cluster sponges attenuated adipocyte ER stress, improved adipocyte endocrine function, and restored plasma APN levels in MI/R animals.

Conclusions:
We demonstrate for the first time that MI/R causes significant adipocyte ER stress and endocrine dysfunction by releasing miR-23-27-24 cluster-enriched small extracellular vesicle. Targeting small extracellular vesicle–mediated cardiomyocyte-adipocyte pathological communication may be of therapeutic potential to prevent metabolic dysfunction after MI/R.
“After such knowledge, what forgiveness?”
Authors: Kelley Tyler 
Published: November 2021

Abstract
This study attempts to resolve some of the difficulties in understanding Zeph 2:1–3 by offering a holistic reading of the oracle presented in 1:2–2:3. It argues that the passage’s sacrificial imagery and the embedded polemic against the wealthy provide the key to understanding Zephaniah’s audience in Zeph 2:1–3. This analysis suggests that rather than attempting to persuade his audience to change their behavior—as is commonly argued—Zephaniah’s condemnation of the upper classes (e.g., שרים and עם־כנען) offers no hope for the repentant. Instead, Zephaniah extends the possibility of survival only to the poor (ענוי הארץ). This message is then contextualized within the Josianic reform movement to which the book’s heading attributes its content.
Quenching Tears: A Note on 2 Kings 22:17 and 19
Authors: Peeler Josiah D. 
Published: November 2021

Abstract
The verbal forms תִכְבֶּה and וַתִּבְכֶּה in 2 Kgs 22:17 and 19 exhibit metathesis. This metathesis represents the reversal that Josiah’s weeping accomplishes by momentarily delaying Judah’s judgment.
The Role of Actual Democracy in the Link between National Identity and Support for Democracy
Authors: Gabrielsson Daniel 
Published: November 2021

Abstract
This article analyzes the interplay between national identity and democracy. Multilevel models were tested using European Value Survey (EVS 2017), which includes 30 countries in total. On the individual level, emphasis on non-voluntary features of national identity, where national membership depends on the accident of origin, relates to lower support for democracy. At the country level, the level of actual democracy was taken in to account (Varieties of Democracy 2017). In general, higher levels of actual democracy correlate with stronger support for the ideal democracy, yet, a high level of actual democracy amplifies the negative relationship between non-voluntary national identity and support for democracy.
“What the One Thing Shows Me in the Case of Two Things”: Comparison as Essential to a Proper Academic Study of Religion
Authors: Gill Sam 
Published: November 2021

Abstract
Comparison is a fundamental operation in the milieu of the remarkable abilities of human beings to transcend themselves in acts of perception and the accumulation of knowledge. Comparison is holding together things that are at once the same and different. The very possibility of the copresence of same and different, of is and is not, is a gift of human biology and evolution. Humans compare because it is our distinctive nature to do so. Academics have the added responsibility of being self-aware, self-reflective, and articulate when comparing. This article develops a rich theory of comparison in conjunction with detailed reflections on late nineteenth century encounters of European-Australians and Aborigines in Central Australia. The intent is to advance our understanding of comparison and also to articulate in the practical terms of method what is involved in comparison, arguing most generally that comparison is of the fabric of any proper study of religion.
Drafting an International Legally Binding Instrument on Business and Human Rights
Authors: Karska Elżbieta 
Published: November 2021

Abstract
This article deals with the process of creating a convention in the field of human rights, the working name of which is the ‘International Legally Binding Instrument on Business and Human Rights’. The author analyses the existing legal grounds for the responsibility of business for human rights violations in international law. She has assessed non-binding instruments, leading her to draw the conclusion that mechanisms strengthening protection are required in human rights protection law. The process of the creation of a new convention itself is subjected to an in-depth review. A special place is given to the issue of the position of a victim of human rights violations committed as a result of the activity of transnational enterprises, the rights of the victims of such violations and the mechanisms of international cooperation in the combatting thereof. In the conclusion the author states that human rights require actions that move beyond existing divisions, and that the work of the intergovernmental group led by Ecuador should be seriously supported by the European Union and the United States.
Quantifying Energy Balance Regimes in the Modern Climate, Their Link to Lapse Rate Regimes, and Their Response to Warming
Authors: Miyawaki Osamu , Shaw Tiffany A. , Jansen Malte F. 
Published: November 2021

Abstract
Energy balance and lapse rate regimes qualitatively characterize the low, middle, and high latitudes of Earth’s modern climate. Currently we do not have a complete quantitative understanding of the spatiotemporal structure of energy balance regimes [e.g., radiative convective equilibrium (RCE) and radiative advective equilibrium (RAE)] and their connection to lapse rate regimes (moist adiabat and surface inversion). Here we use the vertically integrated moist static energy budget to define a nondimensional number that quantifies where and when RCE and RAE are approximately satisfied in Earth’s modern climate. We find RCE exists year-round in the tropics and in the northern midlatitudes during summertime. RAE exists year-round over Antarctica and in the Arctic with the exception of early summer. We show that lapse rates in RCE and RAE are consistent with moist adiabatic and surface inversion lapse rates, respectively. We use idealized models (energy balance and aquaplanet) to test the following hypotheses: 1) RCE occurs during midlatitude summer for land-like (small heat capacity) surface conditions, and 2) sea ice is necessary for the existence of annual-mean RAE over a polar ocean, such as the Arctic. Consistent with point 1, an aquaplanet configured with a shallow mixed layer transitions to RCE in the midlatitudes during summertime whereas it does not for a deep mixed layer. Furthermore, we confirm point 2 using mechanism-denial aquaplanet experiments with and without thermodynamic sea ice. Finally, we show energy balance regimes of the modern climate provide a useful guide to the vertical structure of the warming response in the annual mean, and seasonally over the tropics and the southern high latitudes.
Confidence Intervals After Variance Stabilization May Go Head-to-Head with Exact Confidence Intervals: A New Class of Illustrations
Authors: Mukhopadhyay Nitis 
Published: November 2021

We begin with an overview on variance stabilizing transformations (VST) along with three classical examples for completeness: the arcsine, square-root and Fisher's z-transformations (Examples 1–3). Then, we construct three new examples (Examples 4–6) of VST-based and central limit theorem (CLT)’based large-sample confidence interval methodologies. These are special examples in the sense that in each situation, we also have an exact confidence interval procedure for the parameter of interest. Tables 1–3 obtained exclusively under Examples 4–6 via exact calculations show that the VST-based (a) large-sample confidence interval methodology wins over the CLT-based large-sample confidence interval methodology, (b) confidence intervals’ exact coverage probabilities are better than or nearly same as those associated with the exact confidence intervals and (c) intervals are never wider (in the log-scale) than the CLT-based intervals across the board. A possibility of such a surprising behaviour of the VST-based confidence intervals over the exact intervals was not on our radar when we began this investigation. Indeed the VST-based inference methodologies may do extremely well, much more so than the existing literature reveals as evidenced by the new Examples 4–6. AMS subject classifications: 62E20; 62F25; 62F12
Does the FT3-to-FT4 ratio easily predict the progression of NAFLD and NASH cirrhosis?
Authors: Türker Fatih , Oral Alihan , Şahin Tolga , Türker Betül Çavuşoğlu , Koçak Erdem , Ataoğlu Hayriye Esra , Ahbab Süleyman 
Published: November 2021

Background Factors causing progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis (NASH) and liver cirrhosis remain relatively unknown. We aimed to evaluate the power and effectiveness of the free triiodothyronine (FT3)-to-free thyroxine (FT4) ratio to predict non-alcoholic fatty liver disease (NAFLD)/liver fibrosis and NASH cirrhosis severity. Methods Patients (n = 436) with NASH-associated liver cirrhosis (n = 68), patients with liver biopsy-proven NAFLD (n = 226), or healthy participants (n = 142) were enrolled between January 2010 and January 2020. The aspartate aminotransferase-to-thrombocyte ratio (APRI), NAFLD fibrosis score, albumin–bilirubin score (ALBI), aspartate aminotransferase (AST)-to-alanine aminotransferase (ALT) ratio, FT3-to-FT4 ratio, and Fibrosis-4 (FIB-4) were calculated and evaluated. Results All parameters were significantly higher in NASH cirrhosis than in the healthy group. Body mass index, ALT, fasting insulin, homeostatic model assessment for insulin resistance, and triglyceride levels were significantly higher in liver biopsy-proven NAFLD than in the healthy group. The APRI, NAFLD fibrosis score, ALBI, AST-to-ALT ratio, FT3-to-FT4 ratio, and FIB-4 were significantly higher in the NASH cirrhosis group than in the healthy group. In patients with biopsy-proven NAFLD, the FT3-to-FT4 ratio was significantly lower than in the healthy group. Conclusion The FT3-to-FT4 ratio is an effective and useful indicator to predict NAFLD/liver fibrosis and NASH cirrhosis severity.
Maximum Voluntary Molar and Incisor Biting Force and Morphological Variables in Subjects With Different Vertical Skeletal Patterns
Authors: Singh Ankita , Tandon Pradeep , Singh Gulshan K , Nagar Amit , Shastri Dipti 
Published: November 2021

Objective: To estimate the maximum voluntary molar biting force (MBF) and incisor biting force (IBF) and their relationship to morphological variables in subjects with different vertical skeletal patterns. Materials and Methods: Maximum voluntary MBF, IBF, and morphological variables were recorded in 120 subjects (60 males and 60 females) with skeletal class I pattern in the age range of 14 to 24 years. All subjects were divided into 3 groups: Normodivergent, hypodivergent, and hyperdivergent, according to the maxillomandibular plane angle and Jarabak ratio. Bite force measurements were undertaken using a custom-made portable digital gnathodynamometer on the left and the right sides of the jaw in the molar and incisor regions during maximal clenching. Statistical analysis was performed using independent t-test, chi-square test, and ANOVA test using SPSS version 22.0.0.0 software. Results: MBF and IBF are influenced by gender with higher values obtained for male subjects in all groups in the following order: hypodivergent > normodivergent > hyperdivergent. No significant changes were seen with morphological variables in different groups. Conclusion: Molar and incisor biting forces are highest in hypodivergent subjects and least in hyperdivergent subjects as a reflection of jaw morphology and muscular efficiency. In all groups, males exhibit higher force values than females, underlining a strong gender influence on biting force and facial pattern.
The exposure levels of phthalates in pregnant women and impact factors of fetal malformation
Authors: Wang Ling , Duan Wei , Zhao Yun , Sun Guoqiang , Lin Ying , Gao Ying 
Published: November 2021

Methods Urine samples were collected from 157 women with fetal malformations (case group) and 147 women with normal fetuses (control group). High-performance liquid chromatography-mass spectrometry (HPLC-MS) was used to detect the content of eight metabolites of phthalate compounds in urine, including monoethyl phthalate (MEP), mononbutyl phthalate (MBP), monoisobutyl phthalate (MiBP), mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono-benzyl phthalate (MBzP). Demographic data were collected from questionnaires administered in specimen collection. Results The exposure level of MEOHP and MEHP in the case group was higher than the others. And there were significant differences between structural malformations and chromosomal malformations in the levels of MEHHP and MEOHP. Pregnant women with low income, high body mass index (BMI), frequent plastic contact, and low nutrients intake were at risk of suffering from fetal malformation. Conclusion This study provides evidence for the correlation between the concentration of phthalates and fetal malformation. In addition, decreasing plastic exposure and supplementing nutrients may reduce the incidence of fetal malformations.