bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compositional variation in early‐life parenting structures alters oxytocin and vasopressin 1a receptor development in prairie voles (Microtus ochrogaster)
Authors: Rogers Forrest D. , Freeman Sara M. , Anderson Marina , Palumbo Michelle C. , Bales Karen L. 
Published: June 2021

AbstractPaternal absence can significantly alter bio‐behavioural development in many biparental species. This effect has generally been demonstrated by comparing the development of offspring reared under biparental care with those reared by a single mother. However, studies employing this design conflate two significant modifications to early‐life experience: removal of father‐specific qualities and the general reduction of offspring‐directed care. In the socially monogamous prairie vole (Microtus ochrogaster), the experience of paternal absence without substitution during development inhibits partner preference formation in adulthood, a hallmark of social monogamy, in females and males. Employing alloparents as substitutes for fathers, our previous work demonstrated that paternal absence affects pair‐bond formation in female offspring via reducedquantityof care, although it affects pair‐bond formation in male offspring by means of a missing paternalquality(or qualities). Here, we present evidence that paternal absence (with and without alloparental substitution) may alter the ontogeny of neural oxytocin receptor (OXTR) and/or vasopressin 1a receptor (AVPR1a) distribution in male and female prairie voles. Compared to biparentally reared controls (BPC), male offspring reared in mother only (MON) and maternal‐plus‐alloparental (MPA) conditions show lower densities of OXTR in the central amygdala; and MPA males show lower densities of OXTR in the caudate putamen and nucleus accumbens. Early‐life experience was not associated with differences in AVPR1a density in males. However, MON and MPA females show greater densities of AVPR1a in the medial amygdala than BPC; and MPA females show greater densities of AVPR1a in the ventromedial nucleus of the hypothalamus. We also demonstrate with corticosterone concentrations that MON and MPA offspring are not differentially susceptible to a stressor (ie, social isolation) than BPC offspring. These findings suggest that paternal absence, although likely not a salient early‐life stressor, has neuroendocrine consequences for offspring, some of which may affect partner preference formation.
Core competencies of clinical nurse specialists: A comparison across three Nordic countries
Authors: Jokiniemi Krista , Hølge‐Hazelton Bibi , Kristofersson Gisli Kort , Frederiksen Kirsten , Kilpatrick Kelley , Mikkonen Santtu 
Published: June 2021

AbstractAimTo describe and compare the clinical nurse specialist core competency use in Finland, Denmark and Iceland.BackgroundClinical nurse specialist roles were first developed more than 60 years ago in the United States. Within the Nordic countries, the clinical nurse specialist role emerged around 2000. There is scarcity of clinical nurse specialist competency descriptions outside of North America, and research has been limited to examine or validate established competencies across different countries.DesignA descriptive correlational study.MethodsAn online survey was conducted from May to September 2019. A population sample of clinical nurse specialists in Finland, Denmark and Iceland was recruited. A validated self‐report questionnaire of clinical nurse specialist competencies was used. The data were analysed using descriptive and inferential statistics, and the STROBE checklist was used as the reporting guideline.ResultsA total sample of 184 clinical nurse specialists, 52 from Finland, 95 from Denmark and 37 from Iceland, participated in the study (response rate = 72%, 35% and 48%, respectively). Overall, clinical nurse specialists utilised the organisational competency most frequently followed by the patient, clinical nursing leadership and scholarship competency. Univariate analysis of variance test between‐country effects showed statistically significant difference in patient competency (p = .000) and in organisational competency (p < .05). There were no statistically significant differences between counties in the utilisation of clinical nursing leadership and scholarship competency.ConclusionA small variability was found in the comparison of the clinical nurse specialist use of core competency in the spheres of patient, nursing, organisation and scholarship within three Nordic countries.Relevance to clinical practiceThe CNS competency scale may be utilised in benchmarking clinical nurse specialist roles and practice within and across countries. The long‐term goal for the competency descriptions is to enhance the clinical nurse specialist role clarity, integration and evaluation as well as inform post‐graduate education.
Digital Workflow for Establishing the Posterior Palatal Seal on a Digital Complete Denture
Authors: Lee Ju‐Hyoung 
Published: June 2021

AbstractThe posterior palatal seal (PPS) plays important roles in improving denture retention, preventing food and debris from entering under the denture base, reducing the gag reflex, providing more strength across the denture, and making the distal border less noticeable to the tongue. Digital dentures have become popular, owing to the use of computer‐aided design and computer‐aided manufacturing and rapid prototyping technologies. However, limited research has been conducted on a digital workflow to establish the PPS. This article presents a technique to establish the PPS by using digital technologies for providing the advantages of the PPS to patients wearing digital dentures.
Entrepreneurial ways of designing and designerly ways of entrepreneuring: Exploring the relationship between design thinking and effectuation theory
Authors: Klenner Nico Florian , Gemser Gerda , Karpen Ingo Oswald 
Published: June 2021

AbstractScholars have suggested that design thinking and effectuation theory may enrich each other. However, to date, we lack deeper theorizing and empirical evidence to further advance this valuable discourse for the benefit of innovation management. Our qualitative study draws on 41 in‐depth interviews with Australian designer‐founders, with the aim to provide a theoretical perspective on and empirical insights into the relationship between the behavioral practices of design thinking and the cognitive principles of effectuation. The contributions are twofold. First, our study explains how design thinking practices enable designer‐founders to enact the cognitive principles of effectuation. Uncovering these “entrepreneurial ways of designing” provides an explanation for the effectiveness of design thinking for entrepreneurial innovation and new venture creation. Second, our study sheds light on the ways in which designer‐founders interpret effectuation principles through the professional values and norms embodied in design thinking. These “designerly ways of entrepreneuring” resemble particular, normative interpretations of effectual action. By doing so, our study offers empirical substantiation and theoretical elaboration of the ways in which design thinking functions as an approach for entrepreneurial innovation and new venture creation. Through shedding light on the “entrepreneurial ways of designing” and “designerly ways of entrepreneuring” exhibited by designer‐founders, our research reveals the reciprocal relationship between design thinking and effectuation theory.
Evaluation of a continuous glucose monitoring system in neonatal foals
Authors: Wong David , Malik Caitlin , Dembek Katarzyna , Estell Krista , Marchitello Megan , Wilson Katie 
Published: June 2021

AbstractBackgroundMonitoring blood glucose concentrations is common in critically ill neonatal foals, especially septic foals and those receiving naso‐esophageal feedings or IV parenteral nutrition. Glucose typically is measured using a point‐of‐care (POC) glucometer but requires repeated restraint and blood collections, which may cause irritation at venipuncture sites and increased demands on nursing staff. Continuous glucose monitoring systems (CGMS) may provide an accurate alternative for monitoring blood glucose concentration.ObjectivesTo determine the correlation and accuracy of a CGMS to monitor neonatal foals' blood glucose concentrations as compared to a POC glucometer and laboratory chemistry analysis (CHEM).AnimalsSamples from 4 healthy and 4 ill neonatal foals.MethodsA CGMS was placed on each foal, and glucose measurements acquired from this device were compared to simultaneous measurements of blood glucose concentration using a POC glucometer and CHEM.ResultsTwo‐hundred matched glucose measurements were collected from 8 neonatal foals. The mean bias (95% limits of agreement) between CGMS and CHEM, CGMS and POC glucometer, and POC glucometer and CHEM was 3.97 mg/dL (−32.5 to 40.4), 18.2 mg/dL (−28.8 to 65.2), and 22.18 mg/dL (−9.3 to 53.67), respectively. The Pearson's correlation coefficient (r) was significantly correlated among all devices: GCMS and CHEM (r = 0.81), CGMS and POC glucometer (r = 0.77) and POC glucometer‐CHEM (r = 0.92).Conclusions and Clinical ImportanceWithin the blood glucose concentration ranges in this study (78‐212 mg/dL), CGMS measurements were significantly correlated with CHEM, suggesting that it is an acceptable method to provide meaningful, immediate, and continuous glucose concentration measurements in neonatal foals while eliminating the need for repeated restraint and blood collection.
Mucormycosis in patients with COVID‐19: A cross‐sectional descriptive multicentre study from Iran
Authors: Pakdel Farzad , Ahmadikia Kazem , Salehi Mohammadreza , Tabari Azin , Jafari Rozita , Mehrparvar Golfam , Rezaie Yasaman , Rajaeih Shahin , Alijani Neda , Barac Aleksandra , Abdollahi Alireza , Khodavaisy Sadegh 
Published: June 2021

AbstractPurposeThe aim of the study was to report clinical features, contributing factors and outcome of patients with coronavirus disease 2019 (COVID‐19)‐associated mucormycosis (CAM).MethodsA cross‐sectional descriptive multicentre study was conducted on patients with biopsy‐proven mucormycosis with RT‐PCR‐confirmed COVID‐19 from April to September 2020. Demographics, the time interval between COVID‐19 and mucormycosis, underlying systemic diseases, clinical features, course of disease and outcomes were collected and analysed.ResultsFifteen patients with COVID‐19 and rhino‐orbital mucormycosis were observed. The median age of patients was 52 years (range 14–71), and 66% were male. The median interval time between COVID‐19 disease and diagnosis of mucormycosis was seven (range: 1–37) days. Among all, 13 patients (86%) had diabetes mellitus, while 7 (46.6%) previously received intravenous corticosteroid therapy. Five patients (33%) underwent orbital exenteration, while seven (47%) patients died from mucormycosis. Six patients (40%) received combined antifungal therapy and none that received combined antifungal therapy died.ConclusionClinicians should be aware that mucormycosis may be complication of COVID‐19 in high‐risk patients. Poor control of diabetes mellitus is an important predisposing factor for CAM. Systematic surveillance for control of diabetes mellitus and educating physician about the early diagnosis of CAM are suggested.
Diabetes mellitus and oral lichen planus: A systematic review and meta‐analysis
Authors: Mallah Narmeen , Ignacio Varela‐Centelles Pablo , Seoane‐Romero Javier , Takkouche Bahi 
Published: June 2021

AbstractObjectiveTo undertake a meta‐analysis of the association of Oral Lichen Planus (OLP) with diabetes, two diseases with an important impact on public health and the economy, but the evidence of which about their association is inconsistent.MethodsRelevant studies were localized by searching MEDLINE, EMBASE, Conference Proceedings, and other databases from inception to October 2020, without restrictions. The reference lists of included studies and of related reviews were also inspected. Global pooled odds ratios were calculated, and predefined subgroup analyses were performed. The heterogeneity between studies and publication bias was assessed and sensitivity analysis was carried out.ResultsThirty‐two studies were included in the meta‐analysis. Pooled ORs showed a moderate association between diabetes and OLP [OR: 1.87 (95%CI: 1.57, 2.34)]. The association is limited to studies carried out on adults only [OR: 2.12 (95%CI: 1.75, 2.57)] and is observed in all study designs. Globally, the heterogeneity was low to moderate. Studies carried out in European populations show a stronger association of diabetes and OLP than Asiatic studies [OR: 2.49 (95%CI: 1.87, 3.32) and 1.60 (95%CI: 1.25, 2.03), respectively].ConclusionsDiabetes and OLP are moderately associated. Systematic diagnosis of diabetes in OLP patients could prove useful.
Diverse clinical features and diagnostic delay in monogenic inborn errors of immunity: A call for access to genetic testing
Authors: Branch Anna , Modi Bhavi , Bahrani Bahar , Hildebrand Kyla J. , Cameron Scott B. , Junker Anne K. , Turvey Stuart E. , Biggs Catherine M. 
Published: June 2021

AbstractBackgroundInborn errors of immunity (IEIs) are a group of conditions affecting immune system development and function. Due to their clinical heterogeneity and lack of provider awareness, patients suffer from long diagnostic delays that increase morbidity and mortality. Next‐generation sequencing facilitates earlier diagnosis and treatment of IEIs, but too often patients are unable to see the benefit of this technology due to gaps in providers’ knowledge regarding which patients to test and barriers to accessing sequencing.MethodsHere, we provide detailed clinical phenotyping and describe the impact of genetic sequencing on a cohort of 43 patients with monogenic IEIs seen in a tertiary care center from 2014 to 2019. Data were abstracted from a chart review, and a panel of clinical immunologists were consulted on the impact of genetic sequencing on their patients.ResultsWe found that our patients had significant diagnostic delays, averaging 3.3 years; had diverse manifestations of immune system dysfunction; and had demonstrated highly complex medical needs, with on average 7.9 subspecialties involved in their care and 4.9 hospitalizations prior to definitive treatment. Our results also demonstrate the benefits of genetic testing, as it provided the majority of our patients with a diagnosis, and positively impacted their treatment, follow‐up, and prognosis.ConclusionThis paper expands the paucity of literature on genetically confirmed IEIs in North America and supports the expansion of access to genetic testing for patients with clinical features suggesting IEI, such as those presented in our cohort.
Anti‐plasma cell treatment in refractory autoimmune hemolytic anemia in a child with multivisceral transplant
Authors: Ghobrial Shahira , Gonzalez Corina Elena , Kaufman Stuart , Yazigi Nada , Matsumoto Cal , Fishbein Thomas , Hawksworth Jason , Ekong Udeme D. , Kroemer Alexander , Khan Khalid 
Published: June 2021

AbstractBackgroundWarm‐antibody AIHA is known to complicate solid organ (SOT) and HSCT, the disease maybe refractory to standard therapy. Immunosuppressive therapies as well as IVIG, and rituximab have been the main stay of treatment. Over the past decade, B‐lymphocyte targeted, anti‐CD‐20 antibody has been recognized in the treatment of autoimmune diseases and utilized in AIHA. Bortezomib, a proteasome inhibitor that causes apoptosis of plasma cells, is an appealing targeted therapy in secondary AIHA and has demonstrated efficacy in HSCT patients. From our experience, we advocate for early targeted therapy that combines B cell with plasma cell depletion.Case ReportWe describe a 4‐year‐old‐girl with stage III neuroblastoma, complicated with intestinal necrosis needing multivisceral transplant developed warm AIHA 1‐year after transplantation, and following an adenovirus infection. She received immunoglobulin therapy, rituximab, sirolimus, plasmapheresis, and long‐term prednisolone with no sustained benefit while developing spinal fractures related to the latter therapy. She received bortezomib for intractable AIHA in combination with rituximab with no appreciable adverse effects. Three years later the child remains in remission with normal reticulocyte and recovered B cells. In the interim, she required chelation therapy for iron overload related to blood transfusion requirement during the treatment of AIHA.ConclusionWe propose early targeted anti‐plasma cell therapy with steroid burst, IVIG, rituximab, and possible plasmapheresis may reduce morbidity in secondary refractory w‐AIHA.
Correct response negativity may reflect subjective value of reaction time under regulatory fit in a speed‐rewarded task
Authors: Files Benjamin T. , Pollard Kimberly A. , Oiknine Ashley H. , Khooshabeh Peter , Passaro Antony D. 
Published: June 2021

AbstractError‐related negativity (ERN), an electroencephalogram (EEG) component following an erroneous response, has been associated with the subjective motivational relevance of error commission. A smaller EEG event, the correct response negativity (CRN), occurs after a correct response. It is unclear why correct behavior evokes a neural response similar to error commission. CRN might reflect suboptimal performance: in tasks where speed is motivationally relevant (i.e., incentivized), a correct but slow response may be experienced as a minor error. The literature is mixed on the relationship between CRN and response time (RT), possibly due to different motivational structures, tasks, or individual traits. We examined ERN and CRN in a go/no‐go task where correctness and speed were encouraged using a points‐based feedback system. A key individual trait, regulatory focus, describes a person's tendency to seek gains (promotion focus) and avoid losses (prevention focus). Trait regulatory focus was measured, and participants were randomly assigned to one of three conditions: points gain, points loss, and informative‐only feedback. Participants committed too few errors to reliably model ERN effects. CRN amplitude related to RT in all feedback conditions, with slower responses having larger CRN. Participants with stronger promotion focus had a more exaggerated RT/CRN relationship in the point gain condition, suggesting that regulatory fit influences the motivational relevance of speed and thus the negative subjective experience and CRN for slower responses. These findings are consistent with the claim that CRN reflects RT when RT is motivationally relevant and that the CRN/RT relationship reflects the degree of subjective motivational relevance.
Disordered Eating, Development of Menstrual Irregularity, and Reduced Bone Mass Change After a 3-Year Follow-Up In Female Adolescent Endurance Runners
Authors: Barrack Michelle T. , Van Loan Marta D. , Rauh Mitchell , Nichols Jeanne F. 
Published: June 2021

This prospective study evaluated the 3-year change in menstrual function and bone mass among 40 female adolescent endurance runners (age 15.9 ± 1.0 years) according to baseline disordered eating status. Three years after initial data collection, runners underwent follow-up measures including the Eating Disorder Examination Questionnaire and a survey evaluating menstrual function, running training, injury history, and prior sports participation. Dual-energy X-ray absorptiometry was used to measure bone mineral density and body composition. Runners with a weight concern, shape concern, or global score ≥4.0 or reporting >1 pathologic behavior in the past 28 days were classified with disordered eating. Compared with runners with normal Eating Disorder Examination Questionnaire scores at baseline, runners with disordered eating at baseline reported fewer menstrual cycles/year (6.4 ± 4.5 vs. 10.5 ± 2.8, p = .005), more years of amenorrhea (1.6 ± 1.4 vs. 0.3 ± 0.5, p = .03), and a higher proportion of menstrual irregularity (75.0% vs. 31.3%, p = .02) and failed to increase lumbar spine or total hip bone mineral density at the 3-year follow-up. In a multivariate model including body mass index and menstrual cycles in the past year at baseline, baseline shape concern score (B = −0.57, p value = .001) was inversely related to the annual number of menstrual cycles between assessments. Weight concern score (B = −0.40, p value = .005) was inversely associated with lumbar spine bone mineral density Z-score change between assessments according to a multivariate model adjusting for age and body mass index. These finding support associations between disordered eating at baseline and future menstrual irregularities or reduced accrual of lumbar spine bone mass in female adolescent endurance runners.
Effect of disease duration on the association between serum albumin and mucosal healing in patients with ulcerative colitis
Authors: Yagi Sen , Furukawa Shinya , Shiraishi Kana , Hashimoto Yu , Tange Kazuhiro , Mori Kenichirou , Ninomiya Tomoyuki , Suzuki Seiyuu , Shibata Naozumi , Murakami Hidehiro , Ohashi Katsuhisa , Hasebe Aki , Tomida Hideomi , Yamamoto Yasunori , Takeshita Eiji , Ikeda Yoshio , Hiasa Yoichi 
Published: June 2021

ObjectiveSerum albumin is used as a marker of acute inflammation. Several studies have addressed the association between serum albumin and clinical outcome in patients with ulcerative colitis (UC). While mucosal healing (MH) has been indicated as the therapeutic goal for UC, the association between serum albumin and MH remains unclear. We evaluated this issue in patients with UC overall and explored whether duration of UC affected this association.DesignThis cross-sectional study recruited consecutive patients with UC. Study subjects consisted of 273 Japanese patients with UC. Serum albumin was divided into tertiles based on its distribution in all study subjects. One endoscopy specialist was responsible for measuring partial MH and MH, which were defined as a Mayo endoscopic subscore of 0–1 and 0, respectively. The association between serum albumin and clinical outcomes was assessed by multivariate logistic regression.ResultsRates of clinical remission, partial MH and MH were 57.9%, 63% and 26%, respectively. Only high serum albumin (>4.4 mg/dL) was significantly positively associated with MH (OR 2.29 (95% CI: 1.03 to 5.29), p for trend=0.043). In patients with short UC duration (<7 years) only, high serum albumin was significantly positively associated with MH and clinical remission. In patients with long UC duration (≥7 years), in contrast, no association between serum albumin and clinical outcomes was found.ConclusionIn Japanese patients with UC, serum albumin was significantly positively associated with MH. In patients with short UC duration, serum albumin might be a useful complementary marker for MH.