bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viktor Frankl e Martin Buber, Deus eclipsado ou inconsciente
Authors: Carvalho José Mauricio de 
Published: July 2021

Neste artigo vamos examinar a influência das teses do filósofo Martin Buber na antropologia e psicologia de Viktor Frankl. Trata-se de influência amplamente admitida pelo psiquiatra. Começa-se indicando como as teses fundamentais de Buber sobre a intersubjetividade foram apreendidas e mencionadas por Frankl para, em seguida, mostrar como essas ideias abrem espaço para uma interpretação psicológica de um fenômeno histórico e filosófico, o do eclipse de Deus da consciência do homem ocidental. O que se procura indicar é que a noção Deus inconsciente corresponde à leitura psicológica do conceito buberiano de eclipse de Deus.

Palavras-chave: Inconsciente espiritual – Eclipse de Deus – Psicologia
Educação financeira: Sequência didática com o aplicativo “Minhas Economias”
Authors: Ramos Maria do Socorro Ferreira , Moura Patrícia de Souza , Lavor Otávio Paulino 
Published: July 2021

A educação financeira é um dos conhecimentos relevantes na vida pessoal e profissional, visto que se aplica em diversas áreas e pode ser entendida como o processo de ensino e aprendizagem para o desenvolvimento da consciência crítico-reflexiva diante das questões financeiras dentre as quais destacam-se o consumo, o planejamento, o investimento. Nesse sentido, pode-se pensar nessa temática aplicando uma sequência didática com o uso de um aplicativo que busque a motivação para aprendizagem da educação financeira em uma turma de ensino médio no Estado do Ceará. Os resultados revelam que os alunos estão disponíveis para um diálogo de aprendizagens e que ao serem submetidos a novos conhecimentos, mostraram-se motivados pelas tecnologias adquirindo a percepção do consumo consciente e planejamento financeiro. O objetivo desse trabalho é encorajar a reflexão e prática docentes para incluir situações favorecedoras da educação financeira mediada por recursos tecnológicos que estimulem a tomada consciente de decisões.
Pkd1 Mutation Has No Apparent Effects on Peroxisome Structure or Lipid Metabolism
Authors: Terabayashi Takeshi , Menezes Luis F. , Zhou Fang , Cai Hongyi , Walter Peter J. , Garraffo Hugo M. , Germino Gregory G. 
Published: July 2021

Key Points

Although fatty acid (FA) oxidation defects have been reported in polycystic kidney disease (PKD), no studies have examined whether peroxisomes contribute to the abnormalities.We investigated peroxisome biogenesis and FA metabolism in autosomal dominant PKD models and tested whether polycystin-1 colocalized with peroxisome proteins.Our studies show that loss of Pkd1 does not disrupt peroxisome biogenesis nor peroxisome-dependent FA metabolism.

Background
Multiple studies of tissue and cell samples from patients and preclinical models of autosomal dominant polycystic kidney disease report abnormal mitochondrial function and morphology and suggest metabolic reprogramming is an intrinsic feature of this disease. Peroxisomes interact with mitochondria physically and functionally, and congenital peroxisome biogenesis disorders can cause various phenotypes, including mitochondrial defects, metabolic abnormalities, and renal cysts. We hypothesized that a peroxisomal defect might contribute to the metabolic and mitochondrial impairments observed in autosomal dominant polycystic kidney disease.

Methods
Using control and Pkd1−/−
kidney epithelial cells, we investigated peroxisome abundance, biogenesis, and morphology by immunoblotting, immunofluorescence, and live cell imaging of peroxisome-related proteins and assayed peroxisomal specific β-oxidation. We further analyzed fatty acid composition by mass spectrometry in kidneys of Pkd1fl/fl;Ksp-Cre mice. We also evaluated peroxisome lipid metabolism in published metabolomics datasets of Pkd1 mutant cells and kidneys. Lastly, we investigated if the C terminus or full-length polycystin-1 colocalize with peroxisome markers by imaging studies.

Results
Peroxisome abundance, morphology, and peroxisome-related protein expression in Pkd1−/−
cells were normal, suggesting preserved peroxisome biogenesis. Peroxisomal β-oxidation was not impaired in Pkd1−/−
cells, and there was no obvious accumulation of very-long-chain fatty acids in kidneys of mutant mice. Reanalysis of published datasets provide little evidence of peroxisomal abnormalities in independent sets of Pkd1 mutant cells and cystic kidneys, and provide further evidence of mitochondrial fatty acid oxidation defects. Imaging studies with either full-length polycystin-1 or its C terminus, a fragment previously shown to go to the mitochondria, showed minimal colocalization with peroxisome markers restricted to putative mitochondrion-peroxisome contact sites.

Conclusions
Our studies showed that loss of Pkd1 does not disrupt peroxisome biogenesis nor peroxisome-dependent fatty acid metabolism.
RESEARCH OF EFFECTIVE TRANSPORT AND LOGISTICS LINKS IN THE ORGANIZATION OF INTERNATIONAL MULTIMODAL TRANSPORT MINERAL FERTILIZERS
Authors: Kulikov Aleksey , Bliznyakova Elena 
Published: July 2021

Modern agriculture cannot do without the use of mineral and organic fertilizers. Mineral fertilizers are produced by large holdings both in Russia and abroad, and Russian enterprises have subsidiaries distributed throughout the world. The latter factor makes mineral fertilizers one of the most export-oriented branches of the chemical industry in Russia. According to official statistics in 2019 Russian agricultural companies supplied more than 21 million tons of mineral fertilizers to foreign markets, which determines the peculiarities of the country's market.
The purpose of the study is to determine the optimal assignment of consumers to suppliers of mineral fertilizers in the organization of multimodal transportation. The article considers the period of the beginning of the reorientation of the production of mineral fertilizers for export. The issue of creating domestic ports specialized in the transshipment of fertilizers has been studied. The volumes of production and consumption of specific countries and regions that are included in export-import operations with each other are analyzed. Routes of transportation of fertilizers with determination of the shortest distances are studied. The optimization of the existing route option for the delivery of nitrogen and potash fertilizers to Brazil is proposed.
Implementasi System Persediaan dengan Metode Grafik dan Penerapan Last In First Out pada Hasanah Collection
Authors: Arief Wisky Irzal 
Published: July 2021

The purpose of this research is to produce applications that can provide information about inventory, because this is very important in the world of organizations engaged in marketing and selling goods. So from that the authors conducted research on hasanah collection, implementation is applied to determine improving the ability of the inventory system in scheduling and selling processes. For this reason, a computerized system was built so as to minimize the calculation error to determine the amount of ending inventory in hasanah collection.
Pusat Informasi Pada Perusahaan Daerah Air Minum (PDAM) Kota Padang Berbasis Web
Authors: Harkamsyah Andrianof  
Published: July 2021

Pemanfaatan teknologi informasi pada PDAM Padang belum optimal, tidak terkecuali pada pengolahan informasi kepada pelanggan yang masih manual. Sehingga menyebabkan informasi yang dibutuhkan tidak efektif dan efesien. Jadi dari hal tersebut penulis mencoba memberikan solusi dengan membangun sebuah sistem informasi pengolahan informasi serta proses transaksi pembayaran tagihan PDAM yang bertujuan untuk membantu atau mempermudah admin dalam melakukan pengolahan data informasi dan pelanggan dalam memperoleh informasi serta mengetahui tarif pembayaran.
Penelitian perpustakaan dan penelitian laboratorium dimana data-data yang diperoleh dikelompokkan terlebih dahulu lalu dalam analisa dan hasil yang digunakan adalah Unified Modelling Language (UML) yang mana diantaranya, Use Case Diagram, Class Diagram, Sequence Diagram, Aktivity Diagram, Collaboration Diagram, dan Deployment Diagram dan aplikasi yang dibangun menggunakan bahasa pemrograman HTML dan PHP Skrip. Sedangkan database yang dipakai adalah MySQL. Dengan pemanfaatan sistem komputerisasi diharapkan penerapan forum e-raport ini nantinya akan mampu mempermudah guru dan siswa dalam proses penilaian hasil pembelajaran serta dalam mendapatkan informasi yang lebih baik dan berkualitas. Sehingga tujuan yang diharapkan untuk kemajuan siswa dan sekolah dapat tercapai
Evaluasi Rasionalitas Penggunaan Obat Anti Inflamasi Non Steroid (OAINS) Di Puskesmas Poli-Polia Kabupaten Kolaka Timur
Authors: Ridwan Bai Athur , Fety Yulli , Nurlinda Nurlinda 
Published: July 2021

Nyeri didefinisikan sebagai perasaan tidak menyenangkan bagi sebagian orang akibat dari kerusakan jaringan, sehingga pasien melakukan pengobatan dan kebanyakan masih berpusat pada terapi farmakologis seperti penggunaan Obat Anti Inflamasi Non Steroid (OAINS). Adanya efek samping yang bisa terjadi maka perlu ditunjang dengan penggunaan yang rasional khususnya pada fasilitas kesehatan. penelitian ini bertujuan untuk mengetahui gambaran rasionalitas penggunaan OAINS di Puskesmas Poli-Polia Kabupaten Kolaka Timur. Jenis penelitian ini merupakan penelitian non eksperimental dengan desain deskriptif retrospektif. Sampel diambil dengan cara total sampling dari populasi yang memenuhi kriteria inklusi yaitu OAINS tunggal maupun kombinasi yang digunakan pasien periode Januari – Maret 2020 dan memiliki data rekam medik lengkap. Jumlah sampel yang diperoleh yaitu sebesar 72 pasien dan datanya dikumpulkan dalam lembar pengumpul data yang memuat identitas pasien, nama obat, dosis, dan aturan pakai. Analisis rasionalitas penggunaan OAINS dinilai dari aspek ketepatan pemilihan obat, ketapatan jumlah, dan ketepatan dosis dan frekuensi yang disajikan secara deskriptif. Hasil penelitian menunjukkan bahwa rasionalitas penggunaan OAINS di Puskesmas Poli-Polia Kabupaten Kolaka Timur tidak seluruhnya tepat. Pada aspek tepat pemilihan obat diperoleh sebesar 86%, tepat dosis dan frekuensi pemberian sebesar 83%, dan tepat jumlah obat mencapai 100% dan secara keseluran bahwa OAINS yang digunakan di Puskesmas Poli-Polia Kabupaten Kolaka Timur belum rasional.
Penyuluhan Pra Nikah Dalam Perspektif Islam Sebagai Upaya Meningkatkan Pengetahuan Tentang Pernikahan Islam
Authors: Israfil Israfil , Salad Muzakir , Aminullah Aminullah , Subakti Subakti 
Published: July 2021

Perceraian di NTB makin meningkat diakibatkan maraknya pernikahan dibawah umur (19 tahun kebawah), kurangnya pemahaman tentang hal-hal yang harus persiapkan sebelum melakukan pernikahan. kondisi ini menjadi dasar melakukan pengabdian dengan tujuan meningkatkan pengetahuan dan pemahaman tentang pernikahan islam melalui kegitan penyuluhan Pra Nikah dalam perspektif Islam. Mitra dalam kegitan ini adalah masyarakat desa Gelogor kabupaten Lombok Barat yang berjumlah 20 orang. Metode pelaksanaan dengan ceramah, diskusi dan tanya jawab. Langkah-langkah kegitan perencanaa, tindakan, dan evalusi. Hasil pre test pemahaman mitra tentang pra nikah dalam Perspektif Islam mendapatkan nilai rata-rata 50 dan hasil posttest rata-rata 90 dengan rata-rata peningkatan 33%. Ini menunjukkan bahwa kegiatan penyuluhan memberikan dampak pada peningkatan pemahaman dan pengetahuan mitra. Meskipun terjadi peningkatan dan pemahaman mitra masih perlu dilakukan sosialisasi dan pempingan secara berkelanjutan.
Pre-Marriage Counseling is an Islamic Perspective as an Effort to Increase Knowledge About Islamic Marriage
Divorce in NTB may increase due to the prevalence of underage marriages (19 years and under), lack of understanding of the things that must be prepared before marriage. This condition becomes the basis for doing service with the aim of increasing knowledge and understanding of Islamic marriage through Pre-Marriage counseling activities from an Islamic perspective. Partners in this activity are the Gelogor village community, West Lombok district, totaling 20 people. The implementation method is lecture, discussion, and question and answer. The steps of planning, action, and evaluation activities. The results of the pre-test of partners' understanding of premarital marriage in the Islamic perspective got an average score of 50 and the posttest results averaged 90 with an average increase of 33%. This shows that the extension activities have an impact on increasing the understanding and knowledge of partners. Although there is an increase and understanding of partners, it is still necessary to carry out socialization and mentoring on an ongoing basis.
Increased adherence to the treatment of comorbid patients with arterial hypertension and chronic obstructive pulmonary disease on the background of complex therapy
Authors: Menshikova I. G. , Magalyas E. V. , Sklyar I. V. , Loskutova N. V. 
Published: July 2021

Aim. To determine the adherence to treatment of patients with arterial hypertension (AH) and chronic obstructive pulmonary disease (COPD) against the background of complex therapy.Materials and methods. We examined 56 patients with stage II hypertension in combination with COPD. Men accounted for 70%, women – 30%. The average age of patients is 52.9±0.46 years. The patients were prescribed a fixed combination of antihypertensive drugs – telmisartan 40 mg with amlodipine 5 mg and COPD therapy according to GOLD. Patients of group 1 (n=30) studied at a health school against the background of drug treatment, patients in group 2 (n=26) did not attend a health school.Results. After 6 months of treatment, the number of patients in group 1 increased (p=0.001) regularly taking antihypertensive drugs, 96.7% of patients began to independently control blood pressure and keep a diary of a patient with hypertension. Patients of group 2 showed a statistically significant increase in the level of awareness of the presence of the disease and the awareness of patients about the risk factors for the development of the disease (p=0.01), although the number of patients controlling blood pressure remained low (p=0.1). In group 1, there was a positive trend in terms of the main risk factors, in group 2 the frequency of the prevalence of risk factors practically did not change. By the 6th month of therapy, all patients in group 1 achieved the target blood pressure, in group 2 – in 73.1% of patients. By the end of the observation, in patients of group 1, against the background of the chosen treatment tactics, there was a significantly more significant decrease in left ventricular mass index (LVMI) with its normalization in 33.3% of patients, indicating regression of LV hypertrophy (p=0.01), as well as a significant increase in the ratio of peak velocities on the mitral valve (E/A), (p=0.01), indicating an improvement in LV diastolic function. In group 2, antihypertensive therapy showed a moderate decrease in LVMI (p=0.1) with normalization of this indicator in only 2 (7.7%) of patients. By the 6th month of treatment, an improvement in the parameters of bronchial patency was revealed, however, in the 2nd group of patients, the changes in these parameters were statistically insignificant.Conclusion. The effectiveness of the treatment of hypertension and COPD depends not only on the choice of the optimal treatment tactics, but also on the patient's compliance with the prescribed therapy regimen. The results obtained indicate a positive effect of the chosen complex treatment regimen on the functional parameters of the left ventricle and bronchial patency.
Clinical and immunological efficiency of dry carbon dioxide baths in patients with asthma and obesity at the ambulatory-polyclinic stage of rehabilitation
Authors: Uksumenko A. A. , Аntonyuk M. V. , Мineeva E. E. , Yurenko A. V. , Khodosova K. K. 
Published: July 2021

Introduction. An important part in the rehabilitation treatment of patients with asthma associated with obesity is the ambulatory-polyclinic stage of rehabilitation that includes drug and physiotherapeutic treatment. Recently, dry carbon dioxide baths (DCDB) are increasingly used.Aim. is to assess the clinical and immunological efficiency of DCDB in the complex rehabilitation treatment of patients with asthma and obesity at the ambulatory-polyclinic stage of rehabilitation.Materials and methods. The study included 60 patients with asthma and obesity admitted to the departments of medical rehabilitation and clinical examination of scientists of the Medical Association of FEB RAS. Patients of the main group (30 subjects) received DCDB and drug therapy. Patients of the comparison group (30 subjects) received only drug therapy. The DCDB procedures were carried out using the “Reabox” device at CO2 concentration of 15-20%, a temperature of 28-30ºC, 10 procedures. The changes in symptoms, ACQ-5 test, and respiratory function were assessed. The parameters of cellular immunity CD3+, CD4+, CD8+, CD16+, CD19+ and the levels of tumor necrosis factor (TNFα), interleukins (IL) IL-2, IL-4, IL-6, IL-10, IL-17A in the blood were analyzed.Results. The achievement of asthma control took less time in patients of the main group. The improvement of bronchial patency was evidenced by the positive dynamics of spirometric indices. After DCDB therapy, an increase in suppressive activity of the cellular immunity, a decrease in the levels of pro-inflammatory cytokine IL-4, IL-17A were revealed. The TNF-α/IL-10 ratio statistically significantly changed due to the increase in the level of anti-inflammatory cytokine IL-10. In the comparison group, the positive dynamics was less pronounced.Conclusion. The use of DCDB increases the clinical and immunological efficiency of the rehabilitation of patients with asthma and obesity at the ambulatory-polyclinic stage. The clinical effect is associated with immunocorrective action, which allows achieving control of the disease in a shorter period of time.
Clinical significance of vitamin d receptor gene polymorphism in children with bronchial asthma
Authors: Potapova N. L. , Markovskaya A. I. , Gaymolenko I. N. 
Published: July 2021

Introduction. The development of chronic allergic inflammation of the respiratory tract is determined by various genes. It is assumed that the clinical features of the course of bronchial asthma may be associated with singlet polymorphism of the vitamin D receptor.Аim. To analyze the frequency of occurrence of polymorphic variants of the VDR-63980G>A gene and evaluate their association with the features of the development and course of bronchial asthma in children.Materials and methods. To study the association of the VDR-63980G>A gene polymorphism with bronchial asthma in children, 154 patients with bronchial asthma aged 1 to 18 years and 116 healthy subjects were selected. The objective status of the patients was assessed with the clarification of the anamnesis, standard laboratory and instrumental examination. Single nucleotide substitutions were typed by polymerase chain reaction with real-time detection of the results. The genotype distribution was evaluated using the “Gen-Expert” program.Results. As a result of the association analysis, the relationship of VDR-63980G>A with bronchial asthma in children was established. The presence of genotype -63980AA of the VDR gene increases the risk of developing bronchial asthma in a child by 1.85 times (OR=1.85, [CI 1.02-3.38]; χ 2=4.22, p=0.04). The homozygous genotype -63980GG was more common in the control group – in 49.5% versus 45.4% against the sick children. The genotype of the minor homozygote -63980AA is associated with the early onset of the disease, pronounced obstructive pulmonary ventilation disorders.Conclusion. The association of genotype -63980AA of the VDR gene with the risk of asthma development in preschool children was revealed.
PENGARUH REWARD DAN PUNISHMENT TERHADAP KINERJA PEGAWAI
Authors: Sofiati Evi 
Published: July 2021

Abstrak - Tujuan penelitian ini adalah untuk mengetahui dan menganalisis: (1) Reward (2) Punishment; (3) Kinerja Pegawai; serta (4) Pengaruh Reward dan Punishment terhadap Kinerja Pegawai di Madrasah Ibtidaiyah Sains Baiturrahman Jatinangor, baik secara simultan maupun parsial. Metode penelitian yang digunakan dalam penelitian ini adalah survei deskriptif dan survei eksplanatori, unit analisis dalam penelitian ini adalah para staf di lingkungan pegawai Madrasah Ibtidaiyah Sains Baiturrahman Jatinangor dengan sampel sebanyak 30 orang. Tipe investigasinya adalah causalitas, serta time horizon dalam penelitian ini adalah cross-sectional. Berdasarkan hasil penelitian, diperoleh bahwa Reward pada pegawai Madrasah Ibtidaiyah Sains Baiturrahman Jatinangor ternyata pegawai memberikan tanggapan baik, Punishment pada pegawai Madrasah Ibtidaiyah Sains Baiturrahman Jatinangor pada umumnya dapat dikatakan baik, kinerja pegawai pada Madrasah Ibtidaiyah Sains Baiturrahman Jatinangor saat ini dinilai baik. Reward dan Punishment secara simultan berpengaruh terhadap kinerja pegawai Madrasah Ibtidaiyah Sains Baiturrahman Jatinangor. Namun secara parsial Reward dominan mempengaruhi kinerja pegawai daripada Punishment. Karena Reward lebih dominan mempengaruhi kinerja pegawai, menjadi prioritas pertama dalam meningkatkan kinerja pegawai. maka Madrasah Ibtidaiyah Sains Baiturrahman Jatinangor disarankan untuk tetap konsisten mempertahankan sistem reward yang ada, sehingga pegawai mampu bekerja lebih profesional

Abstract - The purpose of this study was to determine and analyze : (1) Reward, (2) Punishment, (3) Employee Performance, and (4) The Effect of Reward and Punishment on the performance of employees in the Islamic Elementary Science School Baiturrahman Jatinangor, both simultaneously and partially. The research method used in this study is a descriptive survey and an explanatory survey, the unit of analysis in this study is the staff in the Islamic Elementary Science environment Baiturrahman Jatinangor with a sample of 30 people. The type of investigation is causality and time horizon in this study is croos-sectional. Based on the results of the study, it was found that the reward of the Islamic Elementary Science School Baiturrahman Jatinangor employees turned out to give good responses, Punishment for Islamic Elementary Science School Baiturrahman Jatinangor employees in general can be said to be good, Employee performance of Islamic Elementary Science School Baiturrahman Jatinangor this time rated good. Simultaneously Reward and Punishment affect the performance of Islamic Elementary Science School Baiturrahman Jatinangor employees. But partially, the dominant reward influences employee performance rather than punishment. Becauce Reward are more dominant in influencing employee performance, it is the first priority inimproving employeeperformance then Islamic Elementary Science School Baiturrahman Jatinangor is advised to remain consistent in maintaining the existing reward system, so that employees are able to work more professionally.