bluuebunny/crossref_metadata_2025_split huggingface dataset:
A EXTENSÃO UNIVERSITÁRIA COMO PROTAGONISTA DE UMA EDUCAÇÃO EMANCIPATÓRIA: EXPERIÊNCIAS DO PROJETO DE EXTENSÃO DIREITO INTERGERACIONAL E TRANSVERSALIDADE DA UNIVALI
Authors: Labiak Fernanda Pereira , Novais Melissa Mendes de , Nunes Ariella Cappellari , Silva Matheus Oliveira da 
Published: January 2021

O presente trabalho tem por objetivo apresentar o papel da extensão universitária na educação emancipatória das(os) acadêmicas(os) e na disseminação de conhecimentos na comunidade. Para tal, foi feita a análise qualitativa dos dados coletados a partir das atividades realizadas pelo projeto de Extensão Direito Intergeracional e Transversalidade, do campus São José (SC), da Universidade do Vale do Itajaí, no segundo semestre de 2019, em que se trabalhou a temática intitulada o enfrentamento à violência de gênero, por meio de oficinas, palestras e cine debates realizados com a comunidade. A partir da análise dos dados foi possível refletir a importância do papel da extensão no diálogo entre universidade e comunidade, apresentando os impactos para os sujeitos envolvidos nas ações extensionistas realizadas.
Do Tunisian Universities need organizational commitment?
Authors: HAJRI Mehdi 
Published: January 2021

Higher Education is a real lever of growth for developing countries such as Tunisia. The aim of our study is to show the importance of organizational commitment in the intention of running the university well.
As a result, the review of the literature enabled us to analyze a concept of attitude at work, namely organizational commitment, which in our opinion can constitute a major lever for carrying out the university development strategies.
It has been established that academics remain committed to their vocation and thereby demonstrate their continued commitment to their students despite the workload, administrative tasks and research carried out (Houston et al., 2006).
Gamification” of teaching science, technology, engineering and mathematics (STEM): Conceptual cartography
Authors: Riaz Anum , Awais Muhammad Taimoor 
Published: January 2021

Conceptual mapping was to study the term gamification in science, technology, engineering, and mathematics (STEM) learning. In total, 287 texts were obtained, of which 39 documents were selected for review. The axes of analysis were: notion, categorization, characterization, differentiation, division, linkage, methodology and exemplification. The result consisted of a systematization of the gamification concept and its methodological aspects for teaching STEM. The main findings will differentiation between gamification, serious educational games, and game-based learning. This will allow planning.
The purpose of this documentary research, carried out with the method of Conceptual Cartography, was to make a conceptual study of the term “gamification”, specifically in the learning of science, technology, engineering and mathematics (STEM). A total of 287 texts were obtained and finally 39 documents were selected for revision. Eight axes of analysis were applied: notion, categorization, characterization, differentiation, division, linkage, methodology and exemplification. The result was a systematization of the concept “gamification” and its methodological aspects for the teaching of STEM. The main finding was a differentiation between “gamification”, “educative serious games” and “game-based learning”. This would allow planning differentiated educational strategies according to specific teaching objectives.
CTRP9 protects against MIA-induced inflammation and knee cartilage damage by deactivating the MAPK/NF-κB pathway in rats with osteoarthritis
Authors: Zheng Shicheng , Ren Jing , Gong Sihai , Qiao Feng , He Jinlong 
Published: January 2021

AbstractC1q/TNF-related protein 9 (CTRP9), the closest paralog of adiponectin, has been reported to protect against inflammation-related diseases. However, its role in regulating osteoarthritis (OA) has not been fully elucidated. First, a rat model of OA was generated. Furthermore, rats with OA were injected with different doses of recombinant CTRP9 protein (rCTRP9), and the knee cartilage damage was evaluated. Finally, the phosphorylation of p38 and the secretion of matrix metalloproteinases (MMPs) were detected by Western blotting and enzyme-linked immunosorbent assay. Results revealed that CTRP9 was highly expressed in adipose tissue, followed by skeletal muscle and cartilage tissue, and less expressed in liver, kidney and lung. Moreover, the expression of CTRP9 significantly decreased in the monosodium iodoacetate (MIA) group in the knee cartilage and knee synovial fluid, and the contents of interleukin-1β (IL-1β) and IL-6 significantly increased in knee synovial fluid. In addition, rCTRP9 alleviated MIA-induced inflammation, oxidative stress and knee cartilage damage in a dose-dependent way. In addition, rCTRP9 could attenuate the expression of p38MAPK and p-p38 and suppress the expression of nuclear factor-kappa B (NF-κB), p65 and MMPs. Collectively, the results of the present study suggested that CTRP9 alleviates the inflammation of MIA-induced OA through deactivating p38MAPK and NF-κB signaling pathways in rats.
Thermal Stress Development in Low Dimensional Silicon Film: An Analytical Approach
Authors: Yilbas Bekir Sami , Alassar R. S. M. , Al-Dweik Ahmad Y. 
Published: January 2021

Abstract
Thermal excitation of the low dimensional silicon film is introduced and an analytical approach is adopted for the solution of the transport equation. In the analysis, the phonon radiative transport equation is converted into an integral form of the Fredholm equation of the second kind. The analytical approach is extended to include the formulation of thermal stresses for the following cases: (i) stress-free at the edges and (ii) one edge is constrained to have maximum stress while the other edge is set to be stress-free. The analytical and numerical results are evaluated for comparisons. The findings demonstrate that both results are in good agreement. The dimensionless temperature rise at the film mid-thickness becomes sharp for small thickness film. The peak value of thermal stress at the film mid-thickness becomes larger as the film thickness is reduced further. Stress waves generated initially are compressive at the film mid-thickness and they become tensile at both ends of the stress-free film, which becomes more apparent as time increases. Two consecutive compressive and tensile stresses are generated at the mid-thickness of the film as the stress boundary condition is changed to the maximum stress at one edge of the film.
Mathematical models for information classification and recognition of multi-target optical remote sensing images
Authors: Zhang Haiqing , Han Jun 
Published: January 2021

Abstract
Traditionally, three-dimensional model is used to classify and recognize multi-target optical remote sensing image information, which can only identify a specific class of targets, and has certain limitations. A mathematical model of multi-target optical remote sensing image information classification and recognition is designed, and a local adaptive threshold segmentation algorithm is used to segment multi-target optical remote sensing image to reduce the gray level between images and improve the accuracy of feature extraction. Remote sensing image information is multi-feature, and multi-target optical remote sensing image information is identified by chaotic time series analysis method. The experimental results show that the proposed model can effectively classify and recognize multi-target optical remote sensing image information. The average recognition rate is more than 95%, the maximum robustness is 0.45, the recognition speed is 98%, and the maximum time-consuming average is only 14.30 s. It has high recognition rate, robustness, and recognition efficiency.
Analytical solution of one-dimensional Pennes’ bioheat equation
Authors: Wang Hongyun , Burgei Wesley A. , Zhou Hong 
Published: January 2021

Abstract
Pennes’ bioheat equation is the most widely used thermal model for studying heat transfer in biological systems exposed to radiofrequency energy. In their article, “Effect of Surface Cooling and Blood Flow on the Microwave Heating of Tissue,” Foster et al. published an analytical solution to the one-dimensional (1-D) problem, obtained using the Fourier transform. However, their article did not offer any details of the derivation. In this work, we revisit the 1-D problem and provide a comprehensive mathematical derivation of an analytical solution. Our result corrects an error in Foster’s solution which might be a typo in their article. Unlike Foster et al., we integrate the partial differential equation directly. The expression of solution has several apparent singularities for certain parameter values where the physical problem is not expected to be singular. We show that all these singularities are removable, and we derive alternative non-singular formulas. Finally, we extend our analysis to write out an analytical solution of the 1-D bioheat equation for the case of multiple electromagnetic heating pulses.
New emotional model environment for navigation in a virtual reality
Authors: Daszuta Marcin , Szajerman Dominik , Napieralski Piotr 
Published: January 2021

Abstract
Emotions are commonly considered to be the most expressive of everyday human experiences, giving a sense of fullness and reality of life. The ability to recognize human emotions as a manifestation of higher intelligence is desirable feature. There are several models of emotional experience that can become the basis for building a universal emotional recognition system. In this article, we check the correctness of the designed emotional model. We check the evaluation of the system’s operation by human observers.
Temporal Prediction Signals for Periodic Sensory Events in the Primate Central Thalamus
Authors: Matsuyama Kei , Tanaka Masaki 
Published: January 2021

Prediction of periodic event timing is an important function for everyday activities, while the exact neural mechanism remains unclear. Previous studies in nonhuman primates have demonstrated that neurons in the cerebellar dentate nucleus and those in the caudate nucleus exhibit periodic firing modulation when the animals attempt to detect a single omission of isochronous repetitive audiovisual stimuli. To understand how these subcortical signals are sent and processed through the thalamocortical pathways, we examined single-neuron activities in the central thalamus of two macaque monkeys (one female and one male). We found that three types of neurons responded to each stimulus in the sequence in the absence of movements. Reactive-type neurons showed sensory adaptation and gradually waned the transient response to each stimulus. Predictive-type neurons steadily increased the magnitude of the suppressive response, similar to neurons previously reported in the cerebellum. Switch-type neurons initially showed a transient response, but after several cycles, the direction of firing modulation reversed and the activity decreased for each repetitive stimulus. The time course of Switch-type activity was well explained by the weighted sum of activities of the other types of neurons. Furthermore, for only Switch-type neurons the activity just before stimulus omission significantly correlated with behavioral latency, indicating that this type of neuron may carry a more advanced signal in the system detecting stimulus omission. These results suggest that the central thalamus may transmit integrated signals to the cerebral cortex for temporal information processing, which are necessary to accurately predict rhythmic event timing.SIGNIFICANCE STATEMENTSeveral cortical and subcortical regions are involved in temporal information processing, and the thalamus will play a role in functionally linking them. The present study aimed to clarify how the paralaminar part of the thalamus transmits and modifies signals for temporal prediction of rhythmic events. Three types of thalamic neurons exhibited periodic activity when monkeys attempted to detect a single omission of isochronous repetitive stimuli. The activity of one type of neuron correlated with the behavioral latency and appeared to be generated by integrating the signals carried by the other types of neurons. Our results revealed the neuronal signals in the thalamus for temporal prediction of sensory events, providing a clue to elucidate information processing in the thalamocortical pathways.
The Wnt Effector TCF7l2 Promotes Oligodendroglial Differentiation by Repressing Autocrine BMP4-Mediated Signaling
Authors: Zhang Sheng , Wang Yan , Zhu Xiaoqing , Song Lanying , Zhan Xinhua , Ma Edric , McDonough Jennifer , Fu Hui , Cambi Franca , Grinspan Judith , Guo Fuzheng 
Published: January 2021

Promoting oligodendrocyte (OL) differentiation represents a promising option for remyelination therapy for treating the demyelinating disease multiple sclerosis (MS). The Wnt effector transcription factor 7-like 2 (TCF7l2) was upregulated in MS lesions and had been proposed to inhibit OL differentiation. Recent data suggest the opposite yet underlying mechanisms remain elusive. Here, we unravel a previously unappreciated function of TCF7l2 in controlling autocrine bone morphogenetic protein (BMP)4-mediated signaling. Disrupting TCF7l2 in mice of both sexes results in oligodendroglial-specific BMP4 upregulation and canonical BMP4 signaling activationin vivo. Mechanistically, TCF7l2 binds toBmp4gene regulatory element and directly represses its transcriptional activity. Functionally, enforced TCF7l2 expression promotes OL differentiation by reducing autocrine BMP4 secretion and dampening BMP4 signaling. Importantly, compound genetic disruption demonstrates that oligodendroglial-specific BMP4 deletion rescues arrested OL differentiation elicited by TCF7l2 disruptionin vivo. Collectively, our study reveals a novel connection between TCF7l2 and BMP4 in oligodendroglial lineage and provides new insights into augmenting TCF7l2 for promoting remyelination in demyelinating disorders such as MS.SIGNIFICANCE STATEMENTIncomplete or failed myelin repairs, primarily resulting from the arrested differentiation of myelin-forming oligodendrocytes (OLs) from oligodendroglial progenitor cells, is one of the major reasons for neurologic progression in people affected by multiple sclerosis (MS). Usingin vitroculture systems andin vivoanimal models, this study unraveled a previously unrecognized autocrine regulation of bone morphogenetic protein (BMP)4-mediated signaling by the Wnt effector transcription factor 7-like 2 (TCF7l2). We showed for the first time that TCF7l2 promotes oligodendroglial differentiation by repressing BMP4-mediated activity, which is dysregulated in MS lesions. Our study suggests that elevating TCF7l2 expression may be possible in overcoming arrested oligodendroglial differentiation as observed in MS patients.
VIBRATION OF 2D-FGSW TIMOSHENKO BEAMS UNDER A MOVING HARMONIC LOAD
Authors: Nguyen Kien Dinh 
Published: January 2021

Vibration of two-directional functionally graded sandwich (2D-FGSW) Timoshenko beams under a moving harmonic load is investigated. The beams consist of three layers, a homogeneous core and two functionally graded skin layers with the material properties continuously varying in both the thickness and length directions by power functions. A finite element formulation is derived and employed to compute the vibration characteristics of the beams. The obtained numerical result reveals that the material inhomogeneity and the layer thickness ratio play an important role on the natural frequencies and dynamic response of the beams. A parametric study is carried out to highlight the effects of the power-law indexes, the moving load speed and excitation frequency on the vibration characteristics of the beams. The influence of the beam aspect ratio on the vibration of the beams is also examined and discussed.
IMMOBILIZATION OF EXCHANGEABLE CROMIUM IN A CONTAMINATED SOIL USING NATURAL ZEOLITE AS AN EFFECTIVE ADSORBENT
Authors: Dang Van Minh , Van Huu Tap , Nguyen Thi Bich Hanh , Nguyen Dinh Vinh , Nguyen Thị Tuyet , Tran Thi Ngoc Ha , Hoang Trung Kien , Tran Thị Pha , Dam Ha Luong Thanh , Duong Thi Minh Hoa , Nhuong Manh Nhuong 
Published: January 2021

This work investigated the effects of soil pH and the content ratio of natural zeolite on Cr contaminated soil. The immobilization experiments of the exchangeable Cr in contaminated soils were conducted using the batch method. The incubation experiments were carried out over 30 days in plastic bottles to determine five fraction of Cr existence (exchangeable fraction (F1), Fe/Mn/Oxide (F2), carbonate bound (F3), organic matters (F4) and residual (F5)) in amended soils after incubation. Results showed that the content and proportion of the exchangeable Cr decreased with an increase in soil pH from 5 to 9. At soil pH 5, the exchangeable Cr in soil reduced from 44.80±0.772 mg/kg (initial soil) to 17.72±0.300 mg/kg after 30 days of incubation with natural Zeolite 3%. Meanwhile, the exchangeable Cr of soil also decreased with increasing the content ratio of natural zeolite from 1% to 5% in soil. The ratio of 3% was suitable for incubation of the exchangeable Cr in contaminated soil with natural zeolite. The exchangeable Cr in contaminated soil decreased from 80.34% at un-amended soil treatment to 25.06% after incubation of 30 days. The forms of carbonate bound (F3) and organic matters (F4) in amended soils increased to 36.54% and 28% compared with 4.26% and 6.90% in un-amended contaminated soil. Ion exchange, precipitation and adsorption on the surface of natural zeolite might be the potential mechanisms of immobilization of the exchangeable Cr. The results indicated that natural zeolite can be used as the effective adsorbent for immobilizing the exchangeable Cr in contaminated soils and leading to a decrease in the environmental risk from Cr toxicity.
Realisation of mammography screening in Khanty-Mansiysk Autonomous State – Yugra
Authors: Belaya Ju. A. , Zakharova N. A. , Brentnall A. R. 
Published: January 2021

Objective: to perform a retrospective analysis of the quality of mammography screening in Khanty-Mansiysk State Region – Yugra from its beginning to 2018 inclusive.Materials and methods. During this investigation a throughout analysis of epidemiological indicators (breast cancer mortality and morbidity), quality indicators (coverage of the target population, cancer detection in general and early detection, sensitivity and morbidity) and mammographic screening performance indicators (projected and observed morbidity and mortality) was carried out.Results and conclusions. During this period, 572,348 women were screened, 9.7 % of whom were recommended for further screening. The coverage of the target population for one round was 33 %. Screening test sensitivity for the specified period was 80 %. The observed number of women with newly detected breast cancer cases of stage I in 2018 made 42 % (53 cases) higher in comparison with expected numbers, and in stage T2+ it made 21 % (62 cases) less. The observed number of deaths in 2018 was 23.7 % lower than expected. The above-mentioned demonstrates once again that mammography screening in Khanty-Mansiysk State Region – Yugra has led to the improvement of early diagnosis of breast cancer. This, in turn, leads to a steady decline in breast cancer mortality among women over 40 years of age.
Aktualisasi Pemikiran Bustanul Arifin Tentang Politik Hukum Islam di Indonesia
Authors: Itmam Muhammad Shohibul 
Published: January 2021

<p class="05Abstrak">This paper explains the actualization of Bustanul Arifin thought on the politics of Islamic law in Indonesia which aims to find out first, how the epistemology of Bustanul Arifin thoughts on Indonesian Islamic law and scond, how the actualization of Indonesian Islamic law politics from Bustanul Arifin's perspective. This research is a library research or library research, which is carried out by collecting library data by using a critical social and political approach. The research concludes that first, the epistemology used by Bustanul Arifin is to position the Koran and al-Sunnah as the main sources in Islamic law and the development of legal values in the Koran and al-Sunnah using the Ijmak and Qiyas methods in Islamic law. Second, the actualization of Islamic law politics Bustanul Arifin's thought is to elaborate Islamic law with positive law through the transformation of Islamic law in state legislation and institutions, so that there is a union between Islamic law and State law within the framework of State institutions which he calls the institutionalization of Islamic law. Thus, the step that needs to be developed is to determine an institution that is in accordance with the principles and values of Islamic law in the Indonesian context.</p>
The Obstacles of Serbia in Obtaining the European Union Membership Status
Authors: Firmansyah Firmansyah , Muhammad Ali 
Published: January 2021

<p>The European Union (EU) is an intergovernmental and supranational organization enlarging its membership since its formation. Due to the benefits, neighboring European countries are volunteering to join the EU. One of the EU candidate member countries is Serbia. In the process of gaining the status of EU candidate country, Serbia has faced many challenges and yet to fulfill the Copenhagen criteria as the conditions of membership by transforming and strengthening democracy. In the economic field, it is struggling to develop free markets and the rule of law. Serbia has collaborated with the International Criminal Tribunal for the Former Yugoslavia (ICTY) to process the war criminals in the past. Serbia succeeded in obtaining the status of candidate membership of the EU on March 1, 2012, which then became its new chapter. </p>
HPV genotypes and epidemiology in women cervical cancer in Senegal.&nbsp;&nbsp;
Authors: Niane Khadidiatou , Diagne Cheikh Tidiane , Diop Gora , Dia Ndongo , Talla Cheikh , Loucoubar Cheikh , Ndiaye Moussa , Niang Mbayame , Diallo Aissatou , Sembene Pape Mbacké , Ka Sidy , Dieye Alioune , Sall Amadou Alpha , Dem Ahmadou 
Published: January 2021

Abstract
Background Cases of cervical cancer are increasing steadily in sub-Saharan Africa, with over 75,000 new cases and nearly 50,000 deaths a year (Mboumba et al., 2017). In Senegal, pathologies such as cervical cancer are one of the top causes of death and the Human papillomavirus (HPV) is its aetiological agent (Steenbergen et al., 2005). Methods The aim of the study is to analyse the distribution of HPV among Senegalese women with cervical cancer. The main objective of this study is to identify the HPV types associated or “co-associated” with cervical oncogenesis in Senegal. The association with the risk factors of cervin carcinogenesis were analysed as well. Cervical biopsies were performed on the women admitted to Aristide Hospital Le Dantec-Julio Curie Institute. Three methods were used to detect HPV genotypes: SANGER sequencing genotyping (Applied BioSystems), PCR real-time approach technique (HPV 16 & 18 RealTime PCR kit) (www.bioneer.co.kr) and the genotyping approach from Chippron (HPV kit 3.5 LCDArray) (info@chipron.com).Results In this study, 24.16% of monoinfections and 75.83% of multiple infections (co-infections) were noted and the majority were at high risk (HR-HPV types). It appears that the HPV genotypes 16, 18 and 45 are the most found in tumors. The most common types of HPV in our study were HPV 16 (100%), 18 (83%), 45 (33%), 33 (31%), 59 (28%), 35 (12%), 31 (11%), 58 (8%), 39 and 73 (4%), 44, 54 and 68 (3%). In the Dakar region, which had the highest number of cases, a prevalence of 17.89% of HR-HPV co-infections was found and the majority of our patients were on a polygamous diet. Polygamy could therefore be a cofactor in the occurrence of cervical cancer in Senegalese women.Conclusion Polygamy could represent a cofactor in the occurrence of cervical cancer in Senegalese women. No association was found between high-risk HPV co-infections and cancer stages. However, an increase of our cohort would be necessary to affirm these hypotheses.