bluuebunny/crossref_metadata_2025_split huggingface dataset:
Store Atmosphere Pengaruhnya Terhadap Minat Beli Kosumen Pada Toko Roti Breadlife Cabang Bintaro Exchange
Authors: Gracia Bunga Astra , Dipayanti Kris 
Published: August 2021

Penelitian ini bertujuan untuk mengetahui pengaruh store atmosphere terhadap minat beli konsumen pada PT. Dunia Makmur Jaya (BreadLife) Tbk cabang Bintaro Exchange. Jenis penelitian adalah penelitian assosiatif kuantitatif dengan menggunakan kuesioner sebagai metode pengumpulan data disebarkan kepada konsumen Toko Roti Breadlife cabang Bintaro Exchange sebagai obyek penelitian.Teknik sampel menggunakan rumus slovin, tingkat kesalahan 10% diperoleh sampel penelitian 96 responden.Teknik Analisis Data dengan uji validitas, uji reliabilitas, uji koefisien korelasi, uji regresi linier sederhana, uji koefisien determinasi, Uji Hipotesismenggunakan SPSS21. Hasil penelitianmenunjukkan terdapat pengaruh positif dan signifikan antara store atmosphereterhadap minat beli konsumendenganpersamaan regresi Y = 9,885+ 0,758X. Store atmospharemempengaruhi minat beli sebesar 73,2% dan sisanya dipengaruhi oleh variabel lain. Uji t sebesar 4,790 > 1,6612, dan dengan nilai signifikansi 0,000 < 0,1 , artinya H0 ditolak dan H1 diterima, terdapat pengaruh yang positif dan signifikan antara store atmosphrereterhadap minat beli.
Pengaruh Bauran Komunikasi Pemasaran Terpadu Terhadap Niat Berkunjung Wisatawan Di Objek Wisata Air Terjun Way Lalaan Kota Agung Kabupaten Tanggamus Provinsi Lampung
Authors: Ginaldho Haskhory , Sari Aida , Aripin Afri 
Published: August 2021

Pariwisata merupakan salah satu sektor yang berpeluang dalam meningkatkan anggaran pendapatan daerah. Teluk Kiluan terletak di Kelumbayan, Kabupaten Tanggamus, Provinsi Lampung yang merupakan salah satu objek wisata unggulan yang dimiliki Provinsi Lampung dan terkenal dengan keindahan pesona laut terutama daya tarik ikan lumba-lumbanya. Penelitian ini bertujuan untuk mengetahui bagaimana Bauran Komunikasi Pemasaran Terpadu dalam menarik Niat Berkunjung wisatawan di Objek Wisata Air Terjun Way Lalaan, Kota Agung, Kabupaten Tanggamus, Provinsi Lampung. Metode pengambilan sampel menggunakan metode non probability sampling dengan teknik purposive sampling, Populasi dalam penelitian adalah wisatawan yang belum pernah mengunjungi Air Terjun Way Lalaan dan wisatawan domestik dengan jumlah sampel 100 responden. Metode analisis statistik yang digunakan adalah regresi linier berganda, pengujian signifikan simultan uji (F), pengujian signifikan parsial (uji t), dan analisis determinasi (R2). Hasil penelitian ini menunjukkan bahwa: Periklanan (X1), Promosi Penjualan (X2), Penjualan Personal (X3), Pemasaran Langsung (X4), Hubungan Masyarakat (X5) dan e-WOM (X6) berpengaruh positif secara signifikan dengan sumbangan sebesar 82,4% terhadap Niat Berkunjung. Hasil penelitian dengan menggunakan analisis kuantitatif membuktikan bahwa variabel dengan nilai beta terbesar adalah Periklanan (X1) yang memiliki nilai beta sebesar 0,440 sedangkan variabel Promosi Penjualan (X2) memberikan pengaruh terkecil dengan nilai beta sebesar 0,109
Pengaruh Current Ratio, Total Asset Turnover dan Net Profit Margin Terhadap Return On Asset (PT Wilmar Cahaya Indonesia, Tbk. 2010-2019)
Authors: Ningrum Prima Novia , Nurmasari Ifa 
Published: August 2021

Tujuan dilakukannya penelitian ini guna mengetahui apakah rasio keuangan yaitu Current Ratio, Net Profit Margin dan Total Asset Turnover mempunyai pengaruh terhadap variabel terikat Return On Assets PT Wilmar Cahaya Indonesia Tbk tahun 2010-2019. Data sekunder digunakan dalam penelitian ini. Penelitian ini termasuk penelitian kuantitatif. Penelitian ini menggunakan berbagai pengujian, meliputi regresi linier berganda, asumsi klasik, dan uji hipotesis yang terdiri dari uji F dan uji t. Selain itu dilakukan juga uji koefisien determinasi. Penelitian ini menunjukkan hasil bahwa Net Profit Margin dan Total Asset Turnover memberikan pengaruh pada variabel Return On Asset. Sementara variabel Current Ratio tidak memberikan pengaruh terhadap variabel Return On Asset. Variabel-variabel ini secara simultan memberikan pengaruh 89,1% pada Return On Assets.
MCTS Based Approach for Solving Real-time Railway Rescheduling Problem
Authors: Lövétei István Ferenc , Kővári Bálint , Bécsi Tamás 
Published: August 2021

Solving a real-time Railway Traffic Management Problem (rtRTMP) is a challenging task for human operators. To solve the traffic situation, many factors need to be considered. Traditionally, the most critical factor is the availability of the possible routes and the relative position of the vehicles to each other. Besides, additional constraints can be found, such as the velocity, the length, and railway company regulations. The human decision-making process is essential in case of any disturbance (deviation from the pre-planned timetable). The human operator may solve this situation, but generally, the solution is not optimal. In this paper, the authors present a new method, where they consider an MCTS based algorithm to solve the traffic situation in a fast way in a given station. The performance of the algorithm is examined in two abstraction levels. The main purpose is to execute an experimental study to examine the efficiency of the MCTS based algorithms to solve railway traffic situations.
Депривація приватності в умовах карантинних обмежень
Authors: Khazratova Nigora , Gnatko Oryslava-Kamila , Oliinyk Alla 
Published: August 2021

Метою нашого дослідження був аналіз переживання приватності в умовах карантину,зумовленого пандемією COVID-19. У ситуації карантинних обмежень відбулися зміниособистісного простору: приватний простір «стиснувся» (тривале перебування багатьохлюдей у просторово обмежених оселях), а публічний простір, навпаки, «розсунувся» (вимогатримати дистанцію 1,5-2,5 м в усіх громадських місцях). Це могло спричинити деприваціюпотреби у приватності в перших ситуаціях і, навпаки, задоволення цієї потреби – у других.Методологічно дослідження ґрунтується на наукових підходах до психології приватності(викладених у працях І. Альтмана, М. Горовця, С. Нартової-Бочавер). Контроль над своїмжиттєвим простором (переживання власності на нього) сприяє вираженості інтернальноголокусу контролю. Найчутливішими до порушень міжособових дистанцій удома виявилисянейротичні особистості: люди лабільні та реактивні схильні вибудовувати більші дистанціїнавіть у спілкуванні з близькими людьми. Жінки значно частіше, ніж чоловіки, зазнавалипорушень приватності вдома, під час карантину, що узгоджується з даними про гендерніособливості фемінінних ролей. Суб’єктивний дискомфорт, порушення приватності інапруженість під час перебування вдома в період карантину більшою мірою відчувалиукраїнці, ніж американці, що пов’язано зі значно більшим показником площі помешканьамериканських респондентів. Виявлено, що американські респонденти встановлюють значноменші дистанції в спілкуванні з близькими людьми і значно більші – з чужими (порівняно зукраїнцями). Це можна пояснити наявною в американській культурі сакралізацією сім’ї, атакож регламентованістю спілкування в громадських місцях, пов’язаною з властивоюангломовним культурам повагою до приватності незнайомої людини. Обмеженнядослідження полягають у незначній за обсягом вибірці респондентів. Результати дослідженняможна використати: 1) для розроблення психологічних рекомендацій щодо впровадженняпросторових обмежень (наприклад, під час карантинних заходів); 2) для профілактики
конфліктів, спровокованих порушенням приватності. Перспективи дослідження полягають вурізноманітненні етнічного складу вибірок для проведення кроскультурного аналізупереживання приватності.
Hypermethylation and Downregulation of UTP6 Are Associated With Stemness Properties, Chemoradiotherapy Resistance, and Prognosis in Rectal Cancer: A Co-expression Network Analysis
Authors: Zhang Yiyi , Gao Qiao , Wu Yong , Peng Yong , Zhuang Jinfu , Yang Yuanfeng , Jiang Weizhong , Liu Xing , Guan Guoxian 
Published: August 2021

BackgroundTo identify the hub genes associated with chemoradiotherapy resistance in rectal cancer and explore the potential mechanism.MethodsWeighted gene co-expression network analysis (WGCNA) was performed to identify the gene modules correlated with the chemoradiotherapy resistance of rectal cancer.ResultsThe mRNA expression of 31 rectal cancer patients receiving preoperative chemoradiotherapy was described in our previous study. Through WGCNA, we demonstrated that the chemoradiotherapy resistance modules were enriched for translation, DNA replication, and the androgen receptor signaling pathway. Additionally, we identified and validated UTP6 as a new effective predictor for chemoradiotherapy sensitivity and a prognostic factor for the survival of colorectal cancer patients using our data and the GSE35452 dataset. Low UTP6 expression was correlated with significantly worse disease-free survival (DFS), overall survival (OS), and event- and relapse-free survival both in our data and the R2 Platform. Moreover, we verified the UTP6 expression in 125 locally advanced rectal cancer (LARC) patients samples by immunohistochemical analysis. The results demonstrated that low UTP6 expression was associated with worse DFS and OS by Kaplan-Meier and COX regression model analyses. Gene set enrichment and co-expression analyses showed that the mechanism of the UTP6-mediated chemoradiotherapy resistance may involve the regulation of FOXK2 expression by transcription factor pathways.ConclusionLow expression of the UTP6 was found to be associated with chemoradiotherapy resistance and the prognosis of colorectal cancer possibly via regulating FOXK2 expression by transcription factor pathways.
Feasibility and Safety of Permanent Left Bundle Branch Pacing in Patients With Conduction Disorders Following Prosthetic Cardiac Valves
Authors: Wei Hui-Qiang , Li Hui , Liao Hongtao , Liang Yuanhong , Zhan Xianzhang , Zhang Qianhuan , Deng Hai , Wei Wei , Liao Zili , Liu Yang , Liu Fangzhou , Lin Weidong , Xue Yumei , Wu Shulin , Fang Xianhong 
Published: August 2021

Background: The feasibility and safety of left bundle branch pacing (LBBP) in patients with conduction diseases following prosthetic valves (PVs) have not been well described.Methods: Permanent LBBP was attempted in patients with PVs. Procedural success and intracardiac electrical measurements were recorded at implant. Pacing threshold, complications, and echocardiographic data were assessed at implant and follow-up visit.Results: Twenty-two consecutive patients with atrioventricular (AV) conduction disturbances (10 with AV nodal block and 12 with infranodal block) underwent LBBP. The PVs included aortic valve replacement (AVR) in six patients, mitral valve repair or replacement (MVR) with tricuspid valve ring (TVR) in four patients, AVR with TVR in one patient, AVR with MVR plus TVR in three patients, transcatheter aortic valve replacement (TAVR) in five patients, and MVR alone in three patients. LBBP succeeded in 20 of 22 (90.9%) patients. LBB potential was observed in 15 of 22 (68.2%) patients, including 10 of 15 (66.7%) patients with AVR/TAVR and five of seven (71.4%) patients without AVR/TAVR. AVR and TVR served as good anatomic landmarks for facilitating the LBBP. The final sites of LBBP were 17.9 ± 1.4 mm inferior to the AVR and 23.0 ± 3.2 mm distal and septal to the TVR. The paced QRS duration was 124.5 ± 13.8 ms, while the baseline QRS duration was 120.0 ± 32.5 ms (P = 0.346). Pacing threshold and R-wave amplitude at implant were 0.60 ± 0.16 V at 0.5 ms and 11.9 ± 5.5 mV and remained stable at the mean follow-up of 16.1 ± 10.8 months. No significant exacerbation of tricuspid valve regurgitation was observed compared to baseline.Conclusion: Permanent LBBP could be feasibly and safely obtained in the majority of patients with PVs. The location of the PV might serve as a landmark for guiding the final site of the LBBP. Stable pacing parameters were observed during the follow-up.
Branched-Chain Amino Acid Catabolism and Cardiopulmonary Function Following Acute Maximal Exercise Testing in Adolescents
Authors: Gumus Balikcioglu Pinar , Ramaker Megan E. , Mason Kelly A. , Huffman Kim M. , Johnson Johanna L. , Ilkayeva Olga , Muehlbauer Michael J. , Freemark Michael , Kraus William E. 
Published: August 2021

Background: To provide energy for cardiopulmonary function and maintenance of blood glucose, acute aerobic exercise induces lipolysis, fatty acid oxidation (FAO), glycolysis, and glycogenolysis/gluconeogenesis. These adaptations are mediated by increases in cortisol, growth hormone (GH), and catecholamines and facilitated by a decline in insulin. Branched-chain amino acids (BCAA) also undergo catabolism during intense exercise. Here, we investigated the relationship between BCAA catabolism and metrics of cardiopulmonary function in healthy, well-developed, mature adolescent athletes undergoing an acute bout of maximal aerobic exercise.Hypothesis: We hypothesized: (a) acute maximal exercise in adolescents induces lipolysis, FAO, and BCAA catabolism associated with increases in GH and cortisol and a reduction in insulin; (b) increases in GH are associated with increases in ghrelin; and (c) metrics of cardiopulmonary function (aVO2, rVO2, aVO2/HRmax) following maximal exercise correlate with increases in GH secretion, FAO, and BCAA catabolism.Methods: Blood samples before and after maximal cardiopulmonary exercise in 11 adolescent athletes were analyzed by tandem-mass spectrometry. Paired, two-tailed student's t-tests identified significant changes following exercise. Linear regression determined if pre-exercise metabolite levels, or changes in metabolite levels, were associated with aVO2, rVO2, and aVO2/HRmax. Sex and school of origin were included as covariates in all regression analyses.Results: Following exercise there were increases in GH and cortisol, and decreases in ghrelin, but no changes in glucose or insulin concentrations. Suggesting increased lipolysis and FAO, the levels of glycerol, ketones, β-hydroxybutyrate, and acetylcarnitine concentrations increased. Pyruvate, lactate, alanine, and glutamate concentrations also increased. Plasma concentrations of valine (a BCAA) declined (p = 0.002) while valine degradation byproducts increased in association with decreases in urea cycle amino acids arginine and ornithine. Metrics of cardiopulmonary function were associated with increases in propionylcarnitine (C3, p = 0.013) and Ci4-DC/C4-DC (p &lt; 0.01), byproducts of BCAA catabolism.Conclusions: Induction of lipolysis, FAO, gluconeogenesis, and glycogenolysis provides critical substrates for cardiopulmonary function during exercise. However, none of those pathways were significantly associated with metrics of cardiopulmonary function. The associations between rVO2, and aVO2/HRmax and C3 and Ci4-DC/C4-DC suggest that the cardiopulmonary response to maximal exercise in adolescents is linked to BCAA utilization and catabolism.
Fluoride Exposure and Probabilistic Health Risk Assessment Through Different Agricultural Food Crops From Fluoride Endemic Bankura and Purulia Districts of West Bengal, India
Authors: De Ayan , Mridha Deepanjan , Ray Iravati , Joardar Madhurima , Das Antara , Chowdhury Nilanjana Roy , Roychowdhury Tarit 
Published: August 2021

The present study investigates the magnitude of fluoride (F−) contamination in agricultural land soil and food crops from F− endemic regions of Bankura and Purulia districts in West Bengal. Mean fluoride level in agricultural soil was 114 ± 59 mg/kg (n = 41) and 126 ± 65 mg/kg (n = 47) in Bankura and Purulia districts, respectively. Considering the food crops cultivated in Bankura (n = 79) and Purulia (n = 108), the mean fluoride concentration in nonleafy vegetables (18.1 ± 6.51 mg/kg and 15.6 ± 5.93 mg/kg) and leafy vegetables (12.8 ± 2.8 mg/kg and 18.4 ± 6.33 mg/kg) from the two studied districts was comparatively higher than that in the cereal (2 ± 1.05 mg/kg and 2.01 ± 1.01 mg/kg) and pulses (3.35 ± 1.42 mg/kg and 4.82 ± 1.19 mg/kg). The BCF values of fluoride in food crops (n = 27) from Bankura (range: 0.007–0.377) and Purulia (range: 0.005–0.319) were much lower than the optimum value of 1. Estimated daily intake (EDI) of fluoride was the highest for children in both Bankura (EDIcumulative = 0.0291 mg/kg bw/day) and Purulia (EDIcumulative = 0.0326 mg/kg bw/day) among all the studied age groups. The nonleafy vegetables contributed the highest exposure of fluoride (approximately 55.5%) to EDIcumulative among all the food crops. The uncertainty analysis for assessment of probabilistic health risk was carried out for all the studied age groups through hazard index (HI), total hazard index (THI), and lifetime noncarcinogenic risk (HILTNR). However, HI value was found to be &lt;1 for all the age groups resulting in no such kind of potential health risk of fluorosis through consumption of individual food crops, and the trend of THI from all the food crops was found in the order of children &gt; adults &gt; adolescents &gt; teenagers from both districts. The lifetime noncarcinogenic risk (HILTNR) of fluoride with percentile doses from P5 to P95 (exploring the model of Monte Carlo simulation) in all the studied age groups (4–70 years) was found to be &gt;1 indicating that the inhabitants were more vulnerable for their total lifetime period of fluoride exposure through consumption of food crops.
A Bibliometric Analysis of Pyroptosis From 2001 to 2021
Authors: Ma Dan , Yang Bin , Guan Baoyi , Song Luxia , Liu Qiyu , Fan Yixuan , Zhao Lin , Wang Tongxin , Zhang Zihao , Gao Zhuye , Li Siming , Xu Hao 
Published: August 2021

BackgroundPyroptosis is a new programmed cell death discovered in recent years. Pyroptosis plays an important role in various diseases. Nevertheless, there are few bibliometric analysis systematically studies this field. We aimed to visualize the research hotspots and trends of pyroptosis using a bibliometric analysis to help understand the future development of basic and clinical research.MethodsThe articles and reviews regarding pyroptosis were culled from Web of Science Core Collection. Countries, institutions, authors, references and keywords in this field were visually analyzed by using CtieSpace and VOSviewer software.ResultsA total of 2845 articles and reviews were included. The number of articles regarding pyroptosis significantly increased yearly. These publications mainly come from 70 countries led by China and the USA and 418 institutions. We identified 605 authors, among which Thirumaladevi Kanneganti had the most significant number of articles, and Shi JJ was co-cited most often. Frontiers in immunology was the journal with the most studies, and Nature was the most commonly cited journal. After analysis, the most common keywords are nod like receptor family pyrin domain containing 3 inflammasome, apoptosis, cell death, gasdermin D, mechanism, caspase-1, and others are current and developing areas of study.ConclusionResearch on the pyroptosis is flourishing. Cooperation and exchanges between countries and institutions must be strengthened in the future. The related pathway mechanism of pyroptosis, the relationship between pyroptosis and other types of programmed cell deaths as well as the role of pyroptosis in various diseases have been the focus of current research and developmental trends in the future research.
The Corrosion Resistance of Graphene-Modified Oily Epoxy Coating on AZ31 Magnesium Alloys
Authors: Gao Zhengyuan , Sun Chengjin , Du Lianteng , Yang Dong , Zhang Xiang , An Zhiguo 
Published: August 2021

In order to enhance the corrosion resistance of AZ31 magnesium alloy, graphene-modified oily epoxy resin coating (G/OEP) were prepared on the surface of magnesium alloy. SEM observations show that graphene has fewer surface defects, and can significantly improve the surface quality of the coating and reduce defects. FI-TR testing shows that coating are mainly composed of epoxy resin (polyurethane) and its corresponding curing agent. Electrochemical testing shows that the coating can provide good corrosion protection for magnesium alloy. Compared with the corrosion current density of magnesium alloy of 6.20 × 10−7 A/cm2, the G/OEP can significantly reduce the corrosion current density to 6.96 × 10−12 A/cm2. Analysis of the morphology of the coating after electrochemical corrosion found that graphene can improve the shielding ability of the coating to corrosive media, and reduce the damage of corrosion to the coating structure, and enhance the corrosion resistance of the coating. The content of graphene for excellent corrosion resistance of coating during this experiment is 0.6 wt%. The graphene can fill the defects generally in the coating during the curing process to prevent substrate from penetration of corrosive media caused by the density and hydrophobicity of coating are increased.
Predictors of Seizure Freedom in Patients Undergoing Surgery for Central Nervous System Infection-Related Epilepsy: A Systematic Review and Meta-Analysis
Authors: Hou Zhi , Duan Qing-Tian , Ke Yan-Yan , An Ning , Yang Hui , Liu Shi-Yong , Zhang Chun-Qing 
Published: August 2021

Objective:Central nervous system infections (CNSIs), especially viral encephalitis and meningitis, are well-recognized causes of medically refractory epilepsy. Although surgery is an effective and durable intervention against these infections, the seizure control outcomes described in previous surgical series have been variable. Accordingly, it is not clear which variables are most valuable in predicting seizure control following surgery for CNSI. The aim of this meta-analysis was to identify the predictors of favorable surgical outcomes in CNSI-related epilepsy.Methods:The PubMed, EMBASE, Cochrane Library, WANGFANG, VIP, CBM, and CNKI databases were searched for studies according to the inclusion criteria. Prognostic factors, surgical outcomes, and patient characteristics were extracted. Heterogeneity was detected by the I2and Q statistics.Results:Seventeen studies were included in our meta-analysis. Eight predictors of favorable outcomes (Engel Class I/II) were determined, including abnormal MRI findings, meningitis, temporal location only, regional ictal pattern, unilateral ictal pattern, older age at epilepsy, longer silent period, and longer time from infection, as follows: OR = 3.34 (95% CI 1.44–7.74), OR = 0.31 (95% CI 0.13–0.70), OR = 0.34 (95% CI 0.16–0.74), OR = 5.65 (95% CI 1.75–18.30), and OR = 9.53 (95% CI 2.36–38.48), respectively, and MD = 2.15 (95% CI 0.20–4.11), MD = 2.40 (95% CI 0.09–4.70), and MD = 8.49 (95% CI 1.50–15.48), respectively. A subgroup analysis found the following associations: regional and unilateral ictal patterns in viral encephalitis, a younger age at infection in parasitic encephalopathy, an older age at surgery, a longer time from onset, and a longer time from infection in unexplained meningitis. A sensitivity analysis restricted to studies that included each variable yielded robust results. Little evidence of publication bias was observed.Conclusions:This meta-analysis suggests that abnormal MRI findings, meningitis, temporal location only, regional and unilateral ictal patterns, older age at epilepsy, longer silent period, and longer time from infection are predictive factors in patients with favorable surgical outcomes in CNSI-related epilepsy. In addition, different infective agents influenced the results in regional and unilateral ictal patterns in ictal electroencephalography, as well as the relationship between age at infection and surgery and the time from epilepsy onset and infection.