bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coffee and Tea Consumption Impact on Amyotrophic Lateral Sclerosis Progression: A Multicenter Cross-Sectional Study
Authors: Cucovici Aliona , Ivashynka Andrei , Fontana Andrea , Russo Sergio , Mazzini Letizia , Mandrioli Jessica , Lisnic Vitalie , Muresanu Dafin Fior , Leone Maurizio Angelo 
Published: July 2021

Background/objectives: Amyotrophic lateral sclerosis (ALS) is a devastating and still untreatable motor neuron disease. The causes of ALS are unknown, but nutritional factors may impact the rate of disease progression. We aimed to ascertain the influence of coffee and tea consumption on ALS progression rate.Subjects/methods: In this multicenter cross-sectional study, we recruited 241 patients, 96 females, and 145 males; the mean age at onset was 59.9 ± 11.8 years. According to El Escorial criteria, 74 were definite ALS, 77 probable, 55 possible, and 35 suspected; 187 patients had spinal onset and 54 bulbar. Patients were categorized into three groups, according to their ΔFS (derived from ALS Functional Rating Scale-Revised score and disease duration from onset): slow (81), intermediate (80), and fast progressors (80).Results: Current coffee consumers were 179 (74.3%), 34 (14.1%) were non-consumers, and 22 (9.1%) were former consumers, whereas six (2.5%) consumed decaffeinated coffee only. The log-ΔFS was weakly correlated with the duration of coffee consumption (p = 0.034), but not with the number of cup-years, or the intensity of coffee consumption (cups/day). Current tea consumers were 101 (41.9%), 6 (2.5%) were former consumers, and 134 (55.6%) were non-consumers. Among current and former consumers, 27 (25.2%) consumed only green tea, 51 (47.7%) only black tea, and 29 (27.1%) both. The log-ΔFS was weakly correlated only with the consumption duration of black tea (p = 0.028) but not with the number of cup-years.Conclusions: Our study does not support the hypothesis that coffee or tea consumption is associated with the ALS progression rate.
Mobile Attention Bias Modification Training Is a Digital Health Solution for Managing Distress in Multiple Sclerosis: A Pilot Study in Pediatric Onset
Authors: Charvet Leigh , George Allan , Cho Hyein , Krupp Lauren B. , Dennis-Tiwary Tracy A. 
Published: July 2021

Introduction: Emotional health is important dimension of care for patients living with pediatric onset multiple sclerosis (POMS), but few options are available for stress and anxiety reduction. The high burden of interventions requiring regular in person and onsite visits for treatment are less feasible. Attention bias modification training (ABMT) is effective for anxiety reduction in adult and adolescent populations. We tested the feasibility and preliminary efficacy of ABMT delivered through a mobile gamified version as a digital emotional health tool for patients with POMS.Methods: Participants with POMS were consecutively recruited from the NYU Langone Pediatric MS Care Center and enrolled to complete a 1-month intervention with use of the Personal Zen ABMT app on their mobile personal device. Feasibility was evaluated by use of the 1-month intervention and efficacy was measured by changes in depression, anxiety, and affect.Results: A total n = 35 patients with POMS were enrolled in the study (Mage = 17.7, SD = 2.2 years, range 14–23). Feasibility criteria were met with 74% completing the full intervention time, and 100% of the sample completing at least 50% of targeted intervention use. Initial efficacy was found for a reduction in negative affect from baseline to intervention end [M = 22.88, SD = 9.95 vs. M = 19.56, SD = 7.37; t(33) = 2.47, p = 0.019]. Anxiety also significantly decreased from pre to post-intervention in adults [M = 11.82, SD = 9.90 vs. M = 7.29, SD = 7.17; t(16) = 3.88, p = 0.001] and youth [M = 51.14, SD = 19.66 vs. M = 40.86, SD = 27.48; t(13) = 3.17, p = 0.007].Conclusion: Mobile ABMT with the Personal Zen app is a feasible and accessible digital emotional health tool for patients with POMS and may have broader application for managing distress across chronic neurological conditions.
Adipose Stromal Cell-Secretome Counteracts Profibrotic Signals From IPF Lung Matrices
Authors: Vasse Gwenda F. , Van Os Lisette , De Jager Marina , Jonker Marnix R. , Borghuis Theo , Van Den Toorn L. Tim , Jellema Pytrick , White Eric S. , Van Rijn Patrick , Harmsen Martin C. , Heijink Irene H. , Melgert Barbro N. , Burgess Janette K. 
Published: July 2021

Introduction: Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease characterized by excess deposition and altered structure of extracellular matrix (ECM) in the lungs. The fibrotic ECM is paramount in directing resident cells toward a profibrotic phenotype. Collagens, an important part of the fibrotic ECM, have been shown to be structurally different in IPF. To further understand the disease to develop better treatments, the signals from the ECM that drive fibrosis need to be identified. Adipose tissue-derived stromal cell conditioned medium (ASC-CM) has demonstrated antifibrotic effects in animal studies but has not been tested in human samples yet. In this study, the collagen structural integrity in (fibrotic) lung tissue, its interactions with fibroblasts and effects of ASC-CM treatment hereon were studied.Methods: Native and decellularized lung tissue from patients with IPF and controls were stained for denatured collagen using a collagen hybridizing peptide. Primary lung fibroblasts were seeded into decellularized matrices from IPF and control subjects and cultured for 7 days in the presence or absence of ASC-CM. Reseeded matrices were fixed, stained and analyzed for total tissue deposition and specific protein expression.Results: In both native and decellularized lung tissue, more denatured collagen was observed in IPF tissue compared to control tissue. Upon recellularization with fibroblasts, the presence of denatured collagen was equalized in IPF and control matrices, whereas total ECM was higher in IPF matrices than in the control. Treatment with ASC-CM resulted in less ECM deposition, but did not alter the levels of denatured collagen.Discussion: Our data showed that ASC-CM can inhibit fibrotic ECM-induced profibrotic behavior of fibroblasts. This process was independent of collagen structural integrity. Our findings open up new avenues for ASC-CM to be explored as treatment for IPF.
Atrial Natriuretic Peptide Inhibited ABCA1/G1-dependent Cholesterol Efflux Related to Low HDL-C in Hypertensive Pregnant Patients
Authors: Dong Yubing , Lin Yi , Liu Wanyu , Zhang Wei , Jiang Yinong , Song Wei 
Published: July 2021

Objective: It has been reported that atrial natriuretic peptide (ANP) regulates lipid metabolism by stimulating adipocyte browning, lipolysis, and lipid oxidation, and by impacting the secretion of adipokines. In our previous study, we found that the plasma ANP concentration of hypertensive disorders of pregnancy (HDP) was significantly increased in comparison to that of normotensive pregnancy patients. Thus, this study’s objective was to investigate the lipid profile in patients with HDP and determine the effects of ANP on the cholesterol efflux in THP-1 macrophages.Methods: A total of 265 HDP patients and 178 normotensive women as the control group were recruited. Clinical demographic characteristics and laboratory profile data were collected. Plasma total triglycerides (TGs), total cholesterol (TC), low-density cholesterol (LDL-C), and high-density cholesterol (HDL-C) were compared between the two groups. THP-1 monocytes were incubated with different concentrations of ANP. ATP-binding cassette transporter A1 (ABCA1) and ATP-binding cassette transporter G1 (ABCG1) mRNA and protein were evaluated. ABCA1- and ABCG1-mediated cholesterol efflux to apolipoprotein A-Ⅰ (apoA-Ⅰ) and HDL, respectively, were measured by green fluorescent labeled NBD cholesterol. Natriuretic peptide receptor A (NPR-A) siRNA and specific agonists of the peroxisome proliferator–activated receptor-γ (PPAR-γ) and liver X receptor α (LXRα) were studied to investigate the mechanism involved.Results: Plasma TG, TC, LDL-C, and LDL-C/HDL-C were significantly increased, and HDL-C was significantly decreased in the HDP group in comparison to the control (all p &lt; 0.001). ANP inhibited the expression of ABCA1 and ABCG1 at both the mRNA and protein levels in a dose-dependent manner. The functions of ABCA1- and ABCG1-mediated cholesterol efflux to apoA-I and HDL were significantly decreased. NPR-A siRNA further confirmed that ANP binding to its receptor inhibited ABCA1/G1 expression through the PPAR-γ/LXRα pathway.Conclusions: ABCA1/G1 was inhibited by the stimulation of ANP when combined with NPR-A through the PPAR-γ/LXRα pathway in THP-1 macrophages. The ABCA1/G1-mediated cholesterol efflux was also impaired by the stimulation of ANP. This may provide a new explanation for the decreased level of HDL-C in HDP patients.
A Randomized Intervention to Assess the Effectiveness of an Educational Video on Organ Donation Intent
Authors: Molmenti Ernesto P. , Finuf Kayla D. , Patel Vidhi H. , Molmenti Christine L. , Thornton Daryl , Pekmezaris Renee 
Published: July 2021

Key Points

Organ donation in the United States is characterized by major racial disparities that are especially prominent in large urban centers.Our study provides unique insight into the causes of these disparities in New York City and potential ways to address and correct them.Our study provides pathways to improve organ donation registration in a large heterogeneous areas to help correct inequities in health care.

Background
The primary objective of this study was to evaluate the effectiveness of an emotive educational video on organ donation intent in New York City. The secondary study objective was to determine if the educational video affected various factors associated with organ donation.

Methods
New York City residents were recruited via a crowdsourcing online platform and randomized to one of two groups, with exposure to viewing (1) an educational video before completing an 81 question survey on organ donation (“video first” condition) or (2) after completing the survey (“video last” condition). Logistic regression analysis compared organ donation intent (i.e., “how likely are you to become an organ donor”) between the two groups. Additional variables related to organ donation (e.g., religious beliefs, financial incentives) were also evaluated between the two groups. Analyses were adjusted for organ donation registration status.

Results
In total, 1905 participants were randomized. We observed a statistically significant increased odds of organ donation intent among those randomized to the video first condition compared with those randomized to the video last condition (odds ratio [OR], 1.70; 95% confidence interval [95% CI], 1.29 to 2.24). Differences regarding both educational effect on nondonors and racial differences such that there was a decreased odds of organ donation intent among those who identified as Black compared with those who were White (OR, 0.66; 95% CI, 0.47 to 0.92). Black participants were also more likely to report bodily integrity and differential treatment by doctors compared with White participants.

Conclusion
Our findings suggest that future interventions to increase organ donation registration among ethnically diverse populations could be effective if sufficient information is presented before decision making to addresses potential concerns.
Isolation and Molecular Characterization of Klebsiella And Enterobacter Species Recovered in Sunflower Seed Agar from Cases Resembling Respiratory Cryptococcosis
Authors: Emele Felix Emele , Daramola Kehinde Caleb , Anyabolu Arthur Ebelenna 
Published: July 2021

Respiratory cryptococcosis caused by Cryptococcus species can present with symptoms indistinguishable from bacterial or viral etiology. Cryptococcus species produce typical colonial features on Sunflower Seed Agar (SSA), which aids in rapid diagnoses of cryptococcosis. In studying respiratory cryptococcosis, we observed bacterial growths on SSA that resembled Cryptococcus species in colonial characteristics. This study aimed at identifying and characterizing those bacterial isolates for documentation. Sputum samples were collected from 201 patients with symptoms suggestive of respiratory cryptococcosis. The samples were inoculated onto SSA, incubated at 37oC for two weeks. Suspected colonies were further evaluated. Of the samples, none yielded Cryptococcus species, although a total of twenty Cryptococcus-resembling bacterial colonies were encountered and isolated. Eight of the isolates could not amplify by PCR techniques. The other twelve were identified as follows: Klebsiella pneumonia (8 or 67%), Klebsiella ozaneae (3 or 25%), and Enterobacter ludwigii (1 or 8%). All isolates were susceptible to Ertapenem, Meropenem, and Fosfomycin but resistant to ampicillin. Results show that Klebsiella and Enterobacter pneumonia-like illnesses can be misidentified as cryptococcosis using SSA. Reliance on microscopic rather than macroscopic, colonial features on SSA will prevent misdiagnosis.
ANALISIS PENGARUH KARAKTERISTIK INDIVIDU, KEAHLIAN, KEPUASAN KERJA TERHADAP KINERJA PEGAWAI DI BADAN PENGELOLAN KEUANGAN DAN ASET DAERAH (BPKAD) KABUPATEN TANAH BUMBU PROVINSI KALIMANTAN SELATAN
Authors: Siti Norliana  
Published: July 2021

Abstrak. Tujuan penelitian ini adalah untuk mengetahui : (1) pengaruh secara parsial antara karakteristik individu terhadap kinerja pegawai, (2) pengaruh secara parsial antara keahlian terhadap kinerja pegawai, (3) pengaruh secara parsial antara kepuasan kerja terhadap kinerja pegawai, (4) pengaruh secara simultan antara karakteristik individu, keahlian dan kepuasan kerja terhadap kinerja pegawai pada Badan Pengelolaan Keuangan dan Aset Daerah Kabupaten Tanah Bumbu. Metode penelitian yang peneliti gunakan adalah Eksplanatori. Populasi penelitian ini adalah seluruh pegawai Badan Pengelolaan Keuangan dan Aset Daerah Kabupaten Tanah Bumbu yang berjumlah 67 orang secara sensus. Pengumpulan data dalam penelitian ini melalui Kuesioner, Wawancara, Dokumentasi dan Observasi, Analisis data dilakukan secara kuantitatif melalui model regresi dengan menggunakan aplikasi SPSS for windows versi 20.0. Hasil penelitian menunjukkan (1) Secara parsial dari persamaan regresi Karakteristik Individu (X1) terhadap Kinerja Pegawai berdasarkan hasil uji t diketahui bahwa t hitung> t Tabel. terbukti kebenarannya, (2) Secara parsial dari persamaan regresi Keahlian (X2) terhadap Kinerja Pegawai Badan Pengelolaan Keuangan dan Aset Daerah Kabupaten Tanah Bumbu berdasarkan hasil uji t diketahui bahwa t hitung> t Tabel. terbukti kebenarannya, (3) Secara parsial dari persamaan regresi Kepuasan Kerja (X3) terhadap Kinerja Pegawai Badan Pengelolaan Keuangan dan Aset Daerah Kabupaten Tanah Bumbu berdasarkan hasil uji t diketahui bahwa thitung> t Tabel. terbukti kebenarannya., (4) Secara simultan dari persamaan regresi dapat dikemukakan bahwa Karakteristik Individu (X1), Keahlian (X2) dan Kepuasan Kerja (X3) terhadap Kinerja Pegawai Badan Pengelolaan Keuangan dan Aset Daerah Kabupaten Tanah Bumbu menunjukan pengaruh yang signifikan karena Berdasarkan hasil uji F diketahui bahwa F hitung>F Tabel. sehingga hipotesis terbukti kebenarannya.
Kata Kunci : Karakteristik Individu, Keahlian, Kepuasan Kerja, Kinerja
Pengaruh Diversitas Dewan Komisaris dan Dewan Direksi Terhadap Kinerja Perusahaan (Studi Empiris: Perusahaan Manufaktur Di BEI Periode 2014-2018)
Authors: LILIS GUSTIANA  , Darmayanti Yeasy , Meihendri Meihendri 
Published: July 2021

This study aims to determine the effect of board of commissioners and board of directors diversity on company performance in manufacturing companies listed on the Indonesia Stock Excharge for the 2014-2018 period. By using purposive sampling method, obtained 45 samples of manufacturing companies listed on the Indonesia Stock Exchange. Based on the results of hypothesis testing, it was found that the age diversity of the board of commissioners had no significant effect on company performance; the diversity of board of commissioners educational background had no significant effect on company performance, the diversity of board of commissioners tenure had a significant effect on company performance. While the diversity of board of directors age had a significant effect on company performance, diversity the of educational backgrounds of the board of directors does not have a significant effect on company performance, and the diversity of tenure of the board of directors does not have a significant effect on company performance.
Keywords : Company Performance, Age, Education, Tenure, Board Of Commissioners Board Of Directors.
Lagniappe: Volunteering in Libraries: An Insider's View, An E-mail Conversation with Elizabeth J. Laney
Authors: Grey Libby 
Published: July 2021

Since retiring in 1991 from the Library of the School of Information and Library Science at the University of North Carolina at Chapel Hill, Elizabeth Laney has continued to serve libraries through volunteer work. From June through December 2003, Laney worked as a volunteer in the Library of the International Baptist Theological Seminary, located in Prague, Czech Republic. Her work for the library focused on cataloging books for the library’s new online catalog system, which integrates acquisitions, cataloging, and circulation. TheSeminary Library has the largest English language theological collection in continental Europe.
Lagniappe: Comics Go to College
Authors: Lewis Megan 
Published: July 2021

or many of us, reading comic books is a formative childhood experience. Indeed, we can “read” comics pictorially before we can actually read. Comics are often the first reading material we select for ourselves and buy with our own money. The small-town newsstand where my brother and I bought Archie comics in the mid-’70s is etched into a corner of my brain: the ring of the bell as we opened the wooden door, the mingled smells of newsprint and tobacco, and the furtive glances towards the counter whilewe read as many comics as possible just out of the proprietor’s sight. Since the 1930s, comics have been an integral part of the American scene. They have both influenced our collective imagination and reflected the eras in which they were published. From movies (The Matrix) to literature (Michael Chabon’s The Amazing Adventures of Kavalier & Clay) to art (Roy Lichtenstein), the footprint of comics on the culture at large is a deep one.
Wired to the World: Xobni
Authors: Scott Ralph L 
Published: July 2021

Microsoft Mail was first introduced in 1988 forAppleTalk networks. Microsoft Mail becameMicrosoft Outlook around 1996 when it wasintroduced with Microsoft’s Exchange server 5.5. It has since become the most popular e-mail system in the world. However as most of us know it is difficult to use and search through for large volumes of incoming and outgoing emails.A San Francisco company called Xobni (inbox spelled backwards and pronounced “sobnee”) hopes to change this with a plug-in program that is an intelligent index and search filter for Outlook. You can download the program for free at www.xobni.com. It does not work with Microsoft Outlook Express, the scaled down version of Outlook.
MODERASI DAKWAH DI ERA DISRUPSI (Studi tentang Dakwah Moderat di Youtube)
Authors: Muzzammil Faisal 
Published: July 2021

This study aims to reveal more about: (1) Moderate Da'wah accounts on Youtube; (2) Moderate preachers on Youtube; (3) Format of Da'wah Content on Youtube. Based on the results of data mining and analysis, several findings were obtained: (1) Three moderate da'wah accounts on Youtube are GusMus Channel with soothing content, CakNun.Com with philosophical content, and Santri Gayeng with traditional content. (2) Three moderate preachers identified on Youtube are Gus Mus with a humanist preaching approach, Cak Nun with a logical preaching approach, and Gus Baha with a millennialist approach to preaching. (3) Three formats of da'wah content on Youtube are short tausiyah format, dialogical discussion format, and lyric video format. There are two recommendations from the results of this study: (1) As a reference for preachers and Muslim content creators in conveying Islamic da'wah messages on social media, especially YouTube, to make it more universal, inclusive and moderate; (2) As a basic framework for academics, social media literacy activists, and Muslim intellectuals, including related stakeholders such as Ministry of Religion Affairs Republik Indonesia in creating and developing an ideal form of religious moderation. Keywords: Moderate Da'wah; Era of Disruption; Youtube content.
Investigation of the Origins of Comets as Revealed through Infrared High-resolution Spectroscopy I. Molecular Abundances
Authors: Lippi M. , Villanueva G. L. , Mumma M. J. , Faggi S. 
Published: July 2021

Abstract
We report and analyze updated molecular abundances in 20 comets obtained by employing modern data reduction procedures and molecular models. Using box and scatter plots, we examine how the different molecular species are distributed among the comet population, while by means of pie charts, we investigate the relative proportions of these molecular species in each comet. We compare these results with the orbital parameters of the selected comets to identify trends related to their dynamical history. With these analyses, we tentatively identify at least three chemical classes based mainly on relative abundances of CO, CH3OH, CH4, C2H6, HCN, and NH3. The combination of relative abundances and orbital parameters is then compared with recent chemical models of planetary system formation. This approach may help in investigating the origins and evolution of the material in cometary nuclei. Among other aspects, we underline the need to increase our sample size, especially for hypervolatiles (i.e., CH4 and CO) in Jupiter family comets.
Where Is the Water? Jupiter-like C/H Ratio but Strong H2O Depletion Found on τ Boötis b Using SPIRou
Authors: Pelletier Stefan , Benneke Björn , Darveau-Bernier Antoine , Boucher Anne , Cook Neil J. , Piaulet Caroline , Coulombe Louis-Philippe , Artigau Étienne , Lafrenière David , Delisle Simon , Allart Romain , Doyon René , Donati Jean-François , Fouqué Pascal , Moutou Claire , Cadieux Charles , Delfosse Xavier , Hébrard Guillaume , Martins Jorge H. C. , Martioli Eder , Vandal Thomas 
Published: July 2021

Abstract
The present-day envelope of gaseous planets is a relic of how these giant planets originated and evolved. Measuring their elemental composition therefore presents a powerful opportunity to answer long-standing questions regarding planet formation. Obtaining precise observational constraints on the elemental inventory of giant exoplanets has, however, remained challenging owing to the limited simultaneous wavelength coverage of current space-based instruments. Here, we present thermal emission observations of the nontransiting hot Jupiter τ Boo b using the new wide wavelength coverage (0.95–2.50 μm) and high spectral resolution (R = 70,000) CFHT/SPIRou spectrograph. By combining a total of 20 hr of SPIRou data obtained over five nights in a full atmospheric retrieval framework designed for high-resolution data, we constrain the abundances of all the major oxygen- and carbon-bearing molecules and recover a noninverted temperature structure using a new free-shape, nonparametric temperature–pressure profile retrieval approach. We find a volume mixing ratio of log(CO) = −

2.46

−
0.29

+
0.25

and a highly depleted water abundance of less than 0.0072 times the expected value for a solar composition envelope. Combined with upper limits on the abundances of CH4, CO2, HCN, TiO, and C2H2, this results in a gas-phase C/H ratio of

5.85

−
2.82

+
4.44

× solar, consistent with the value of Jupiter, and an envelope C/O ratio robustly greater than 0.60, even when taking into account the oxygen that may be sequestered out of the gas phase. Combined, the inferred supersolar C/H, O/H, and C/O ratios on τ Boo b support a formation scenario beyond the water snowline in a disk enriched in CO owing to pebble drift.