bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extinction accounting and accountability: Empirical evidence from the west European tissue industry
Authors: Corvino Antonio , Bianchi Martini Silvio , Doni Federica 
Published: March 2021

AbstractRecently, human activities are more and more invasive with respect to biodiversity. Several studies highlighted the key role played by accountants in contributing to the development of tools able to support company in assessing, reporting, and disseminating, as well as accomplishing, the preservation of natural species and ecosystems (King and Atkins, 2016). Corporate reporting of environmental information might increase the credibility of forest certifications, given that some scholars argued that certified forests are not often run, in a sustainable way. Moreover, certifications sometimes cover harmful forest practices (Elad, 2014) and do not ensure a good quality of environmental reporting and performance. The research question therefore intends to explore how extinction accounting and accountability (EAA) is able to reflect ex post the company's business strategy and, at the same time, influence ex ante its formulation by easing the prevention of deforestation risk and addressing the issue of credibility through specific actions. In more detail, the “Emancipatory Framework for Extinction Accounting and Accountability” (EFEAA) (Atkins and Maroun, 2018) was tested using content and interpretative analyses based on the reports inherent to top four companies working in West Europe in the tissue industry, where the preservation of forest heritage is a “compulsory route” for assuring the business sustainability, in terms of both raw material renewal and brand reputation. The findings highlighted the first attempt to carry out a qualitative research over the management of forest issues. In our study, companies tend to report advantages arising from the use of forest, but this kind of disclosure is too generic without providing evidence over the ecosystem services forests produce. Moreover, firm size affects the quantity and the quality of disclosure. At last, managerial implications and future research avenues are outlined and discussed.
Machine learning for the prediction of bone metastasis in patients with newly diagnosed thyroid cancer
Authors: Liu Wen‐Cai , Li Zhi‐Qiang , Luo Zhi‐Wen , Liao Wei‐Jie , Liu Zhi‐Li , Liu Jia‐Ming 
Published: March 2021

AbstractObjectivesThis study aimed to establish a machine learning prediction model that can be used to predict bone metastasis (BM) in patients with newly diagnosed thyroid cancer (TC).MethodsDemographic and clinicopathologic variables of TC patients in the Surveillance, Epidemiology, and End Results database from 2010 to 2016 were retrospectively analyzed. On this basis, we developed a random forest (RF) algorithm model based on machine‐learning. The area under receiver operating characteristic curve (AUC), accuracy score, recall rate, and specificity are used to evaluate and compare the prediction performance of the RF model and the other model.ResultsA total of 17,138 patients were included in the study, with 166 (0.97%) developed bone metastases. Grade, T stage, histology, race, sex, age, and N stage were the important prediction features of BM. The RF model has better predictive performance than the other model (AUC: 0.917, accuracy: 0.904, recall rate: 0.833, and specificity: 0.905).ConclusionsThe RF model constructed in this study could accurately predict bone metastases in TC patients, which may provide clinicians with more personalized clinical decision‐making recommendations. Machine learning technology has the potential to improve the development of BM prediction models in TC patients.
Innovative methods to test and monitor the preload in mechanical fasteners
Authors: Reiterer Michael 
Published: March 2021

AbstractThe paper presents currently applied methods to test and monitor the preload level in mechanical fasteners and evaluates them with respect to the quality of the gained measuring results. Both, visual inspection methods and electronic state‐of‐the‐art measurement techniques are presented. This contribution introduces recently developed and patented innovative methods to test and monitor the preload level in mechanical fasteners. The methods developed include a smart mechanical fastener with pressure indicator and a smart electronic measuring screw nut. The smart mechanical fastener has no electronic features and is able to display the loss of preload through a red dot that occurs on the upper end of the fastener. The smart measuring screw nut is an electronic fastening element, that records the current value of preload in a time‐discrete or permanent manner. In order to investigate the suitability for daily use and long‐term stability of the novel methods to test and monitor the preload in mechanical fasteners, laboratory experiments and in‐situ tests were executed. The gained results are presented and discussed.
Effect of acetone and methanol environment on the electrical properties of Fe doped hydroxyapatite
Authors: Singh Brajendra , Singh Priyanka , Siddiqui Saiqua , Rajput Parasmani , Gupta Mukul 
Published: March 2021

AbstractWe report huge change in impedance of Fe doped hydroxyapatite Ca9.9Fe0.1(PO4)6(OH)2 in presence of methanol and acetone environment while parent hydroxyapatite Ca10(PO4)6(OH)2 shows only nominal change. Parent and Fe doped hydroxyapatite Ca1−xFex(PO4)6(OH)2 (0 ≤ x ≤ 0.3) samples were prepared by wet chemical method. All the samples are found in single phase using X‐ray diffraction (XRD), and they are crystallized in hexagonal structure. Fe K‐edge X‐ray absorption near edge structure (XANES) spectra show the presence of mixed‐valence states (Fe2+ and Fe3+) in Ca9.9Fe0.1(PO4)6(OH)2 sample while Fe is present in Fe3+ valence state in Ca9.7Fe0.3(PO4)6(OH)2 sample. Fe doped composition Ca9.9Fe0.1(PO4)6(OH)2 has shown the change in impedance (response) ~80% in presence of 50 ppm methanol concentration and ~238% for 500 ppm methanol concentration. Ca9.9Fe0.1(PO4)6(OH)2 has shown ~92% response for 50 ppm acetone concentration and ~537% response for 500 ppm acetone concentration. Analysis of response (change in impedance) using Freundlich adsorption isotherm equation has shown the physical and chemical type of adsorption for methanol while only physical adsorption for acetone is found in Ca9.9Fe0.1(PO4)6(OH)2.
Transmission characteristics of electromagnetic waves in a semicircular plasma filament layer generated by a femtosecond laser
Authors: Pak In‐Ho , Kim Yong‐Ho , Oh Chung‐Hyok , Kim Jun , Han Su‐Il , Jon Guang‐Hi , Han Kye‐Hyon , Kim Hyon‐Chol 
Published: March 2021

AbstractThe transmission characteristics of electromagnetic (EM) waves in a semicircular plasma filament layer generated by a femtosecond laser were studied in a wide frequency band including radar waves. We have focussed on the influence of plasma parameters and filament arrangement based on the diffraction and superposition theory of EM waves on the transmittance. A numerical simulation model using the current density convolution finite‐difference time‐domain method was constructed in a semicircular multilayer filament structure, and the transmission characteristics of spherical EM waves were examined. The simulation results showed that in this semicircular structure, the transmittance was periodically changed at a frequency interval corresponding to the thickness of the filament channel. This phenomenon was more pronounced as the number of the filament layers increased. In the lower band (<30 GHz), there was little change in the transmittance according to layer‐to‐layer distance, but in the higher band (>30 GHz), it changed irregularly. On the contrary, for the electron number density, it changed regularly in the lower frequency and hardly changed in the higher frequency. When the number of layers was 3 or more, the transmittance became 0 at the centre of the channel, and a discontinuous interference pattern appeared more clearly as the frequency increased.
Within‐subject weight variability in bulimia nervosa: Correlates and consequences
Authors: Chen Joanna Y. , Singh Simar , Lowe Michael R. 
Published: March 2021

AbstractObjectiveThe oscillations between binge eating, purging, and dieting in bulimia nervosa (BN) may produce substantial within‐subject weight variability. Although weight variability has been predictive of eating‐ and weight‐related variables in community samples, it has not been empirically examined in eating disorders. The current study examined cross‐sectional and prospective associations between weight variability and BN pathology.MethodFour weights were collected over an average of 42.02 days, and weight variability was calculated as the root mean square error around each individual's weight trajectory regression line. Linear regressions were performed to examine the association between weight variability and eating disorder psychopathology, cross‐sectionally at baseline and prospectively at 6‐month follow‐up, adjusting for baseline BMI.ResultsWeight variability was cross‐sectionally associated with eating pathology, but these relationships became non‐significant after adjusting for BMI. However, at 6‐month follow‐up, greater baseline weight variability predicted increases in body dissatisfaction, shape and weight concerns, and global eating pathology, even after adjusting for baseline BMI.DiscussionThese findings demonstrate, for the first time, that within‐subject weight variability predicts greater eating disorder pathology over time in BN. The results add to evidence that weight history variables contribute to BN psychopathology above and beyond well‐documented psychological dysfunction in BN.
One year improvement of exercise capacity in patients with mechanical circulatory support as bridge to transplantation
Authors: Felix Susanne E.A. , Oerlemans Martinus I.F. , Ramjankhan Faiz Z. , Muller Steven A. , Kirkels Hans H. , van Laake Linda W. , Suyker Willem J.L. , Asselbergs Folkert W. , de Jonge Nicolaas 
Published: March 2021

AbstractAimsMechanical circulatory support (MCS) results in substantial improvement of prognosis and functional capacity. Currently, duration of MCS as a bridge to transplantation (BTT) is often prolonged due to shortage of donor hearts. Because long‐term results of exercise capacity after MCS are largely unknown, we studied serial cardiopulmonary exercise tests (CPETs) during the first year after MCS implantation.Methods and resultsCardiopulmonary exercise tests at 6 and 12 months after MCS implantation in BTT patients were retrospectively analysed, including clinical factors related to exercise capacity. A total of 105 MCS patients (67% male, 50 ± 12 years) underwent serial CPET at 6 and 12 months after implantation. Power (105 ± 35 to 114 ± 40 W; P ≤ 0.001) and peak VO2 per kilogram (pVO2/kg) improved significantly (16.5 ± 5.0 to 17.2 ± 5.5 mL/kg/min (P = 0.008)). Improvement in pVO2 between 6 and 12 months after LVAD implantation was not related to heart failure aetiology or haemodynamic severity prior to MCS. We identified maximal heart rate at exercise as an important factor for pVO2. Younger age and lower BMI were related to further improvement. At 12 months, 25 (24%) patients had a normal exercise capacity (Weber classification A, pVO2 > 20 mL/kg/min).ConclusionsExercise capacity (power and pVO2) increased significantly between 6 and 12 months after MCS independent of Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profile or heart failure aetiology. Heart rate at exercise importantly relates to exercise capacity. This long‐term improvement in exercise capacity is important information for the growing group of long‐term MCS patients as this is critical for the quality of life of patients.
Diagnostic and prognostic implications of heart failure with preserved ejection fraction scoring systems
Authors: Parcha Vibhu , Malla Gargya , Kalra Rajat , Patel Nirav , Sanders‐van Wijk Sandra , Pandey Ambarish , Shah Sanjiv J. , Arora Garima , Arora Pankaj 
Published: March 2021

AbstractAimsWe sought to compare the generalizability and prognostic implications of heart failure with preserved ejection fraction (HFpEF) scores (HFA‐PEFF and H2FPEF score) in Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) and Phosphodiesterase‐5 Inhibition to Improve Clinical Status and Exercise Capacity in Heart Failure with Preserved Ejection Fraction (RELAX) trial participants and matched controls from the Atherosclerosis Risk in Community (ARIC) study.Methods and resultsBased on the respective scores, the study participants from the TOPCAT (N = 356), RELAX (N = 216), and ARIC (N = 379) studies were categorized as having a low, intermediate, or high likelihood of HFpEF. Age, sex, and race matched controls free of cardiovascular disease who had unexplained dyspnoea were used to evaluate the diagnostic performance. The prognostic value of scores was assessed using multivariable‐adjusted Cox regression analyses. The median HFA‐PEFF scores in the TOPCAT, RELAX, and ARIC studies were 5.0 [interquartile range (IQR): 5.0–6.0], 4.0 (IQR: 2.0–4.0), and 3.0 (IQR: 2.0–4.0), respectively. The median H2FPEF scores in the three studies were 5.5 (IQR: 4.0–7.0), 6.0 (IQR: 4.0–7.0), and 3.0 (IQR: 2.0–5.0), respectively. A low HFA‐PEFF and H2FPEF score can rule out HFpEF with high sensitivity (99.5% and 99.6%, respectively) and negative predictive value (95.7% and 98.3%, respectively). A high HFA‐PEFF and H2FPEF score can rule‐in HFpEF with good specificity (82.8% and 95.6%, respectively) and positive predictive value (79.9% and 90.4%, respectively). Among TOPCAT participants, the hazard for adverse cardiovascular events per point increase in HFA‐PEFF and H2FPEF score was 1.26 (95% confidence interval: 0.98–1.63) and 1.01 (95% confidence interval: 0.88–1.15), respectively. A higher H2FPEF score was associated with lower peak oxygen intake in RELAX trial participants (adjusted P = 0.01).ConclusionsThe HFA‐PEFF and the H2FPEF scores are reliable diagnostic tools for HFpEF. The prognostic utility of HFpEF scores requires further validation in larger rigorously phenotyped populations.
Application of Electron‐Rich Covalent Organic Frameworks COF‐JLU25 for Photocatalytic Aerobic Oxidative Hydroxylation of Arylboronic Acids to Phenols
Authors: Xiao Guangjun , Li Wenqian , Chen Tao , Hu Wei‐Bo , Yang Hui , Liu Yahu A. , Wen Ke 
Published: March 2021

AbstractVisible‐light‐driven organic reactions are environmentally friendly green chemical transformations among which photosynthetic oxidative hydroxylation of arylboronic acids to phenols has attracted increasing research interest during the very recent years. Given the efficiency and reusability of heterogeneous catalysts, COF‐JLU25, an electron‐rich COF‐based photocatalyst constructed by integrating electron‐donating blocks 1,3,6,8‐tetrakis(4‐aminophenyl)pyrene (PyTA) and 4‐[4‐(4‐formylmethyl)‐2,5‐dimethoxyphenyl] benzaldehyde (TpDA), was selected as a photocatalyst for the oxidative hydroxylation of arylboronic acids. In our studies, COF‐JLU25 demonstrated excellent photocatalytic activity with high efficiency, robust reusability, and low catalyst loading, showcasing an application potential of previously underexplored COF‐based photocatalyst composed solely of electron‐rich units.
Transcriptional network analysis identifies key elements governing the recombinant protein production provoked reprogramming of carbon and energy metabolism in Escherichia coli BL21 (DE3)
Authors: Li Zhaopeng , Geffers Robert , Jain Garima , Klawonn Frank , Kökpinar Öznur , Nimtz Manfred , Schmidt‐Heck Wolfgang , Rinas Ursula 
Published: March 2021

AbstractThe impact of recombinant protein production on carbon and energy metabolism in Escherichia coli BL21 (DE3) was studied through transcriptome and proteome analysis of cells induced in carbon‐limited fed‐batch cultures during either fast or slow growth. Production of human basic fibroblast growth factor (pET expression system, T7 promoter) during fast growth leads to a macroscopically observable response classifiable into two consecutive steps: i. apparently unperturbed growth and respiration with concomitant formation of pyruvate and acetate followed by ii. inhibition of growth, respiratory activity and glucose uptake. Down‐regulation of genes involved in sugar and acetate uptake, tricarboxylic acid (TCA) cycle, and respiratory energy generation started already during apparently unperturbed growth with the exceptions of up‐regulated genes encoding the less energy efficient NADH dehydrogenase and terminal oxidases. A transcription factor target gene network analysis revealed that observed changes are mainly attributable to the vanishing influence of the transcription factor CRP‐cAMP but also to a strong down‐regulation of AcrA‐P repressed genes. Moreover, down‐regulation of MalT activated and up‐regulation of PdhR repressed genes contribute among others to the reorganization of the transcriptome. The main drivers were identified as accumulating metabolites, for example, pyruvate, which affect transcription factor activity. The resulting restructured proteome leads to reduced glucose uptake, TCA cycle, and respiratory capacities this way decreasing catabolic carbon breakdown and metabolite accumulation. At slow growth, the production provoked transcriptome rearrangements are more subtle not leading to a macroscopically evident response. In summary, the transcriptomic response towards recombinant gene expression mimics a carbon or nutrient up‐shift response aiming to match catabolic carbon processing with compromised anabolic capacities of induced cells. It is not the reason for growth inhibition and the metabolic burden but the cellular attempt to attenuate the “toxic effect” of recombinant gene expression by reducing carbon catabolism.
Preparation and characterization of the Al‐Ga‐In‐Sn‐KCl composites for hydrogen generation
Authors: Sheng Peng , Zhang Songli , Guan Chuang , Qian Wei , Gao Xu , Wang Yanqi 
Published: March 2021

AbstractThe production of hydrogen through the aluminum‐water reaction has received increasing attention in recent years. In this study, a series of Al‐Ga‐In‐Sn‐KCl composites were prepared by mechanical ball milling for hydrogen generation. The effects of composite composition and preparation process on hydrogen generation are studied. It is determined that the optimal ball milling time for the Al‐6Ga‐2In‐1Sn‐1KCl, Al‐5Ga‐2In‐1Sn‐2KCl, and Al‐4Ga‐2In‐1Sn‐3KCl composites to reach their maximum hydrogen yield is 4, 7, and 9 hours, respectively. In particular, the 7 hours milled Al‐5Ga‐2In‐1Sn‐2KCl composite exhibits the best hydrogen generation properties among all composites, achieving a hydrogen yield of 1127 mL g−1 in pure water at 25°C. The microstructure characterization results show that the intermetallic compound In3Sn is formed in these three composites, and the three composites exhibit different morphologies due to their different compositions and different milling times. The effect of initial water temperature is also studied, and the best milled Al‐6Ga‐2In‐1Sn‐1KCl and Al‐5Ga‐2In‐1Sn‐2KCl composites are completely hydrolyzed as the water temperature rises to 60°C. Due to their good hydrogen production capacity, these composites are expected to become an energy source for real‐time hydrogen supply.
The Co‐mutational Spectrum Determines the Therapeutic Response in Murine FGFR2 Fusion‐Driven Cholangiocarcinoma
Authors: Kendre Gajanan , Marhenke Silke , Lorz Georgina , Becker Diana , Reineke‐Plaaß Tanja , Poth Tanja , Murugesan Karthikeyan , Kühnel Florian , Woller Norman , Wirtz Ralph M. , Pich Andreas , Marquardt Jens U. , Saborowski Michael , Vogel Arndt , Saborowski Anna 
Published: March 2021

Background and Aims
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer and a highly lethal malignancy. Chemotherapeutic options are limited, but a considerable subset of patients harbors genetic lesions for which targeted agents exist. Fibroblast growth factor receptor 2 (FGFR2) fusions belong to the most frequent and therapeutically relevant alterations in ICC, and the first FGFR inhibitor was recently approved for the treatment of patients with progressed, fusion‐positive ICC. Response rates of up to 35% indicate that FGFR‐targeted therapies are beneficial in many but not all patients. Thus far, no established biomarkers exist that predict resistance or response to FGFR‐targeted therapies in patients with ICC.

Approach and Results
In this study, we use an autochthonous murine model of ICC to demonstrate that FGFR2 fusions are potent drivers of malignant transformation. Furthermore, we provide preclinical evidence that the co‐mutational spectrum acts not only as an accelerator of tumor development, but also modifies the response to targeted FGFR inhibitors. Using pharmacologic approaches and RNA‐interference technology, we delineate that Kirsten rat sarcoma oncogene (KRAS)–activated mitogen‐activated protein kinase signaling causes primary resistance to FGFR inhibitors in FGFR2 fusion–positive ICC. The translational relevance is supported by the observation that a subset of human FGFR2 fusion patients exhibits transcriptome profiles reminiscent of KRAS mutant ICC. Moreover, we demonstrate that combination therapy has the potential to overcome primary resistance and to sensitize tumors to FGFR inhibition.

Conclusions
Our work highlights the importance of the co‐mutational spectrum as a significant modifier of response in tumors that harbor potent oncogenic drivers. A better understanding of the genetic underpinnings of resistance will be pivotal to improve biomarker‐guided patient selection and to design clinically relevant combination strategies.
Nephrostomy catheter entering the right renal vein during an exchange procedure: A case report and literature review
Authors: Akatsuka Jun , Suzuki Yasutomo , Endo Yuki , Yanagi Masato , Matsuzawa Ichiro , Hamasaki Tsutomu , Kimura Go , Kondo Yukihiro 
Published: March 2021

IntroductionWe encountered an extremely rare case of a nephrostomy catheter entering the right renal vein during an exchange procedure.Case presentationAn 80‐year‐old man underwent radical cystectomy. Urinary diversion was achieved through right percutaneous nephrostomy. After the 15th nephrostomy catheter exchange, the patient bled heavily from the catheter. We clamped the catheter immediately, and the patient became hemodynamically stable. Emergency angiography showed the nephrostomy catheter entering the renal vein from outside the renal pelvis. Under fluoroscopy, we pulled the catheter until its tip was located in the previous penetration site of the renal pelvic wall and inserted the catheter over the guidewire into the renal pelvis.ConclusionsHerein, we report an extremely rare case of a nephrostomy catheter inserted into the right renal vein during an exchange procedure. Inserting a nephrostomy catheter in the appropriate position and performing exchange under imaging guidance techniques could help clinicians avoid severe complications.