bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal PaO 2 is 130-160 mmHg in the first week for sepsis patients in ICU: a retrospective cohort study based on MIMIC-IV database
Authors: Chen Haoran , Tang Xinyi , Li Xiaomin , Xie Yongpeng 
Published: December 2024

Abstract

Background
The relationship between the partial pressure of oxygen in arterial blood (PaO2) and the prognosis of sepsis patients, and its potential variation over time, remains unclear. The optimal PaO2 range for sepsis patients has always been a contentious issue, with no consensus. We aimed to explore the association between different levels of PaO2 exposure over time and the 28-day mortality of sepsis patients, and to identify the optimal PaO2 range for sepsis patients within a specific time frame.

Methods
We retrieved data on adult patients diagnosed with sepsis within 24 hours before or after ICU admission from the Medical Information Mart for Intensive Care IV (MIMIC-IV; version 2.2) database. We excluded patients who were not admitted to the ICU for the first time, those with ICU stay <24 hours, and those without PaO2 results during their ICU stay. We calculated the time-weighted average (TWA) of PaO2 and used piece-wise exponential additive mixed models (PAMMs) to estimate the time-dependent changes in the association between TWA-PaO2 and patient prognosis.

Results
A total of 16,880 sepsis patients were included in the MIMIC cohort. Results indicated that patients' TWA-PaO2 correlates with increased 28-day mortality after intensive care unit (ICU) admission in sepsis patients, and this association was mainly manifested in the early course of the disease. With a time window of the first 1-7 days after ICU admission, the optimal TWA-PaO2 range for sepsis patients was ≥130 mmHg and ≤ 160 mmHg. Increased exposure time, proportion of exposure time, and exposure dose of high-risk PaO2 outside the range were all associated with an increased risk of 28-day mortality.

Conclusion
PaO2 in sepsis patients should be closely monitored. During the first 1-7 days of ICU admission, PaO2 should be maintained within the range of ≥130 mmHg and ≤ 160 mmHg. A dose-dependent relationship exists between high-risk PaO2 outside the range and patient outcome.
Fertility and Sexual Function in Males with Hirschsprung’s Disease
Authors: Söderström Linnea , Axelsson Gustav , Mutanen Annika , Stenström Pernilla , Danielsson Johan , Borg Helena , Telle Hoel Anders , Olsbø Signe , Pakarinen Mikko , Qvist Niels , Bjørnland Kristin , Wester Tomas , Löf Granström Anna 
Published: December 2024

Objective:
The aim was to assess fertility, sexual function and sexual quality of life in males with Hirschsprung’s disease (HSCR) in the Nordic countries with a cross-sectional study using self-reported validated questionnaires.

Summary Background Data:
Data on fertility and sexual function in males with HSCR are limited.

Methods:
This multi-center study targeted all males born between 1970-2003 who underwent pull-through surgery at a pediatric surgery center in Sweden, Denmark, Norway, or Finland. Participants completed a multi-domain questionnaire. Demographic data was collected retrospectively from the medical records. Patients with trisomy 21 and other syndromes associated with intellectual disability were excluded. Main outcomes were fertility, sexual function and sexual quality of life.

Results:
A total of 169 patients (median age 32 y) were included. Of 63 individuals attempting to father a biological child, eight (12.7%) reported failure to conceive after one year and five (7.9%) reported failure to conceive after two years. Our cohort did not report impaired fertility, higher prevalence of erectile dysfunction or lower sexual quality of life scores compared to normative summary data. Poor bowel function was associated with impaired fertility and erectile dysfunction (P=0.0278 and P=0.0026, respectively). Length of the aganglionic segment and surgical method did not seem to affect fertility, sexual function, or sexual quality of life.

Conclusion:
Males with HSCR that have undergone pull-through surgery do not seem to report an overall reduced fertility, higher prevalence of erectile dysfunction or reduced sexual quality of life compared to estimates from the general population. Impaired bowel function may correlate with erectile dysfunction and impaired fertility in affected individuals.
Investigating Anxiety's Impact on Seizure Quality in Electroconvulsive Therapy
Authors: Sassi Kaissar , Bechet Etienne , Martin Louise , Pichon Manuel , Yrondi Antoine , Minville Vincent 
Published: December 2024

Background
Electroconvulsive therapy (ECT) is a medical procedure for treating severe depression and other mental health disorders, with anesthesia management being crucial for patient safety. Despite extensive research on factors influencing seizure quality during ECT, the impact of pre-ECT anxiety remains insufficiently explored.

Methods
This prospective observational study aimed to investigate the influence of pre-ECT anxiety, as measured by the Amsterdam Preoperative Anxiety and Information Scale, on electroencephalogram ictal characteristics during ECT and to explore anesthesia-related factors that may enhance seizure quality.

Results
A total of 38 patients participated in 168 documented ECT sessions over a 2-month period. Data analysis revealed a significant association between higher levels of pre-ECT anxiety, lidocaine doses exceeding 0.36 mg/kg, and decreased seizure quality during ECT sessions.

Conclusion
These findings suggest an association between pre-ECT anxiety, lidocaine dosage, and decreased seizure quality during ECT. Further research, including interventional studies, is required to better understand the causal factors.
Modulating Motor Cortex Plasticity via Cortical and Peripheral Somatosensory Stimulation
Authors: Bao Shancheng , Lei Yuming 
Published: December 2024

AbstractThe interaction between the motor and somatosensory systems is essential for effective motor control, with evidence indicating that somatosensory stimulation influences the excitability of the primary motor cortex (M1). However, the mechanisms by which repetitive stimulation of both cortical and peripheral somatosensory systems affects M1 plasticity are not well understood. To investigate this, we examined the effects of continuous theta-burst stimulation (cTBS) applied to the primary somatosensory cortex (S1) and transcutaneous electrical nerve stimulation (TENS) of the median nerve on various measures of corticospinal excitability and M1 intracortical circuits. Specifically, we assessed motor-evoked potentials (MEPs), short-latency intracortical inhibition (SICI), intracortical facilitation (ICF), and short-latency afferent inhibition (SAI) before and after administering cTBS and TENS. Our results demonstrated that cTBS increased MEPs for at least 50 minutes, whereas TENS increased MEPs for 10 minutes. Neither cTBS nor TENS had an impact on SICI and ICF. However, cTBS decreased SAI, while TENS did not affect SAI. The sham procedures for both cTBS and TENS did not produce significant changes in MEPs, SICI, ICF, or SAI. These findings suggest that both cortical and peripheral somatosensory stimulation modulate corticospinal excitability, with the effects of cortical stimulation being more prolonged. Neither type of stimulation influences inhibitory and excitatory intracortical neural circuitry within M1. Notably, cortical somatosensory stimulation modulates the interaction between M1 and S1, whereas peripheral somatosensory stimulation does not. This study elucidates distinct mechanisms through which cortical and peripheral somatosensory stimulation influence M1 plasticity.NEW & NOTEWORTHYThis study identifies distinct mechanisms through which cortical and peripheral somatosensory stimulation influence motor cortex (M1) plasticity. Both continuous theta-burst stimulation (cTBS) of the primary somatosensory cortex (S1) and transcutaneous electrical nerve stimulation (TENS) of the median nerve enhance corticospinal excitability, with cTBS exhibiting longer-lasting effects. Importantly, cTBS, but not TENS, modulates the interaction between M1 and S1. These findings form the basis for developing targeted somatosensory interventions aimed at modulating motor function.
Time-resolved fluorescent proteins towards fluorescence microscopy in the temporal and spectral domains
Authors: Tan Zizhu , Hsiung Chia-Heng , Feng Jiahui , Zhang Yangye , Chen Junlin , Sun Ke , Lu Peilong , Zang Jianyang , Yang Wenxing , Gao Ya , Yin Jiabin , Zhu Tong , Ye Yuxuan , Wan Yihan , Zhang Xin 
Published: December 2024

ABSTRACTFluorescence microscopy has been widely applied in life sciences. While steady-state fluorescence intensity is mostly used, the time-resolved detection mode relying on fluorescence lifetime remains underexplored. Herein, we present a family of time-resolved fluorescent proteins (TRFP). Using a strategy that regulates lifetime without affecting spectra of FPs, we have developed different TRFPs that cover the visible spectrum and a wide range of lifetime. TRFPs are employed in the temporal-spectral resolved microscopy, allowing the simultaneous imaging of 9 different proteins in live cells and correlation of multiple activities to cell cycles. Finally, TRFPs are integrated into multiplexing super-resolution microscopy to concurrently visualize 4 proteins in live cells, acquiring a remarkable 50 nm spatial resolution using lifetime as signal. TRFPs represent a transformative toolset towards fluorescence microscopy in both the temporal and spectral domains. Beyond the multiplexing imaging, TRFPs could introduce unprecedented opportunities of system complexity and quantitative accuracy into biological research.
Electron-density informed effective and reliablede novomolecular design and lead optimization with ED2Mol
Authors: Li Mingyu , Song Kun , Zhao Mingzhu , You Gengshu , Zhong Jie , Zhao Mengxi , Li Arong , Chen Yu , Li Guobin , Kong Ying , Wei Jiacheng , Wang Zhaofu , Zhou Jiamin , Yang Hongbing , Ma Shichao , Zhang Hailong , Mélita Irakoze Loïca , Lin Weidong , Lu Yuhang , Yu Zhengtian , Lu Xun , He Jixiao , Zhao Yujun , Zhang Jian 
Published: December 2024

AbstractGenerative drug design opens new avenues for discovering novel compounds within the vast chemical space rather than conventional screening against limited compound libraries. However, the practical utility of the generated molecules is frequently constrained, as many designs prioritize a narrow range of pharmacological properties while neglecting physical reliability, which hinders the success rate of subsequent wet-lab evaluations. To address this, we propose ED2Mol, a deep learning-based approach that leverages fundamental electron density information to improvede novomolecular generation and lead optimization. The extensive evaluations across multiple benchmarks demonstrate that ED2Mol surpasses existing methods in terms of generation success rate and >97% physical reliability. It also facilitates automated lead optimization that is not fully implemented by other methods using fragment-based strategies. Furthermore, ED2Mol exhibits generalizability to more challenging, unseen allosteric pocket benchmarks, attaining consistent performance in bothde novomolecule generation and lead optimization. More importantly, ED2Mol has been applied to various real-world essential targets, successfully identifying wet-lab validated bioactive compounds, ranging from FGFR3 orthosteric inhibitors to CDC42 allosteric inhibitors and GCK allosteric activators. The directly generated binding modes of these compounds with target proteins are close to predictions through molecular docking and further validated via the X-ray co-crystal structure. All these results highlight ED2Mol’s potential as a useful tool in realistic drug design with enhanced effectiveness, physical reliability, and practical applicability.
Not all cross-modal responses are explained by face movements
Authors: Olsen Timothy , Hasenstaub Andrea 
Published: December 2024

AbstractRecent work has claimed that most apparently cross-modal responses in sensory cortex are instead caused by the face movements evoked by stimuli of the non-dominant modality. We show that visual stimuli rarely trigger face movements in awake mice; when they occur, such movements do not explain visual responses in auditory cortex; and in simultaneous recordings, face movements drove artifactual cross-modal responses in visual but not auditory cortex. Thus face movements do not broadly explain cross-modal activity across all stimulus modalities.
Colchicine for Prevention of Major Adverse Cardiovascular Events: A systematic review and meta-analysis of randomized clinical trials
Authors: Ballacci Federico , Giordano Federica , Conte Cristina , Telesca Alessandro , Collini Valentino , Imazio Massimo 
Published: December 2024

AbstractAimsInflammation is a main pathophysiological driver in atherosclerotic cardiovascular diseases (ASCVD). Low-dose long-term colchicine for secondary prevention in patients with established ASCVD has been studied in multiple randomized trials in the last decade.This meta-analysis aimed to evaluate the efficacy and safety of long-term low-dose colchicine for secondary prevention in patients with established ASCVD.MethodsWe conducted a systematic review and meta-analysis following PRISMA guidelines to evaluate studies reporting long-term outcomes in patients with ASCVD. We systematically searched PubMed, EMBASE and Scopus databases for relevant studies up to December 1, 2024. The primary outcome was the occurrence of Major Adverse Cardiovascular Events (MACE), a composite of cardiovascular death (CVD), myocardial infarction (MI) and stroke. Random-effects models were used to calculate pooled risk ratios (RR).ResultsTen randomized clinical trials enrolling 22532 patients were identified. Addition of colchicine to standard medical treatment in patients with established ASCVD reduced the risk for MACE by 27% (RR 0.73, 95% CI 0.57 – 0.95), with a number needed to treat of 52. Colchicine was found to significantly reduce the risk of myocardial infarction (RR 0.83, 95% CI 0.72 - 0.96) and coronary revascularization (RR 0.79, 95% CI 0.65 - 0.94). There were no significant differences between the two groups concerning cardiovascular and non-cardiovascular mortality, risk of serious gastrointestinal events, infections requiring hospitalization and cancer.ConclusionsThese findings support the use of long-term low-dose colchicine for secondary prevention of MACE in clinical practice.
Proteomic Insights into the Molecular Correlations Between Coronary Artery Disease and Peripheral Artery Disease in the Project Baseline Health Study
Authors: Tucker Aaliyah , Nguyen Maggie , Kottilil Kalyani , Kwee Lydia Coulter , Daubert Melissa A. , Pagidipati Neha , Douglas Pamela S. , Hernandez Adrian F. , Mahaffey Kenneth W. , Shah Svati H. ,   the Project Baseline Health Study Group
Published: December 2024

ABSTRACTCoronary artery disease (CAD) and peripheral artery disease (PAD) are common and dangerous conditions that are both driven by atherosclerosis. Despite sharing many major risk factors, their disease pathophysiology is not fully understood. In this study, we aimed to better distinguish common vs. unique biological pathways underlying CAD and PAD by proteomics profiling plasma samples from a subset of participants in the Project Baseline Health Study (PBHS). We identified 14 proteins associated with coronary artery calcium (CAC) score ≥100 and 39 proteins associated with the ankle brachial index (ABI) after covariate adjustment. Two proteins (complement component 7 [C7] and polymeric immunoglobulin receptor [PIGR]) were significantly associated with both CAC and ABI. Our work highlights the potential molecular pathways unique to these diseases, which could have therapeutic implications for personalizing clinical management.
Exclusive rare semileptonic decays of
B
and
Bc
mesons in the relativistic independent quark model
Authors: Dash Kalpalata , Dash P. C. , Panda R. N. , Kar Susmita , Barik N. 
Published: December 2024

We investigate the exclusive rare semileptonic decays B(Bc)→K(D(s))ll¯/νlνl¯ (l=μ, τ) in the framework of relativistic independent quark model based on an average flavor independent confining potential in equally mixed scalar-vector harmonic form. The invariant weak form factors, parametrizing the matrix elements between participating meson states, are calculated in the parent meson rest frame. The momentum transfer dependence of the form factors is reliably determined in the whole accessible kinematical range qmin2≤0≤qmax2. Our predicted branching fractions for B→Kμ+μ−/τ+τ−(νlνl¯), Bc→D(Ds)μ+μ−, Bc→D(Ds)τ+τ−, and Bc→D(Ds)νlνl¯, obtained in order of 10−7(10−6), 10−9(10−7), 10−9(10−8), and 10−8(10−7), respectively, are in reasonable agreement with other Standard Model predictions and Lattice QCD results. The averaged values of the lepton polarization asymmetries for decay modes are obtained as ⟨PL(B→Kμ+μ−)⟩=−0.97, ⟨PL(Bc→D(s)μ+μ−)⟩=−0.972, ⟨PL(B→Kτ+τ−)⟩=−0.224, ⟨PL(Bc→Dτ+τ−)⟩=−0.275, and ⟨PL(Bc→Dsτ+τ−)⟩=−0.194.

Published by the American Physical Society
2024
What factors influence consumers’ intention and food waste reduction perceptions in Indian restaurants?
Authors: Wani Mehraj Din , Dada Zubair Ahmad , Shah Shamim Ahmad 
Published: December 2024

PurposeFood waste persists as a critical subject within global academic debates, with consumption identified as the primary stage of loss across both affluent and developing nations. Anchored in the adapted theory of planned behavior, this study examines the multifaceted determinants shaping consumer tendencies to reduce food waste while also exploring the nuanced roles of religious adherence and culinary preferences in influencing both consumer intentions and perceptions toward waste reduction. By dissecting these dynamics, the research endeavors to unravel the complex interplay of psychological, cultural and contextual factors, thereby enriching theoretical discourse and presenting actionable insights for systemic change.Design/methodology/approachData from 476 participants were acquired through an online survey to rigorously interrogate the proposed model. Confirmatory factor analysis (CFA) ensured construct validity, while structural equation modeling (SEM), utilizing SPSS and AMOS, disentangled the intricate interdependencies among latent constructs within the hypothesized framework.FindingsThe analysis reveals that consumer attitudes (β = 0.37) serve as the most salient predictor of their intention to curb food waste, with subjective norms (β = 0.23) demonstrating a comparatively modest effect. Concerning perceptual influences, environmental concern (β = 0.24) significantly shapes consumers’ perceptions toward waste reduction, while food taste (β = 0.15) exhibits the weakest influence in guiding such perceptions.Originality/valueThis study presents groundbreaking insights into tackling food waste at the consumption stage, particularly in restaurant settings. By strategically targeting the underlying drivers of food waste through well-crafted awareness programs, it lays the foundation for transformative changes in consumption behaviors, advancing sustainability and significantly reducing environmental footprints.
Does intraday high-frequency investor sentiment help forecast stock returns? Evidence from the MIDAS models
Authors: Chu Xiaojun , Gu Yating 
Published: December 2024

PurposeThis paper aims to enhance the predictability of stock returns. Existing studies have used investor sentiment to forecast stock returns. However, it is unclear whether high-frequency intraday investor sentiment can enhance the forecasting performance of low-frequency stock returns.Design/methodology/approachThus, we employ the MIDAS model and the high-frequency intraday sentiment extracted from the Internet stock forum to forecast Chinese A-shares returns at daily frequency.FindingsThe results illustrate that high-frequency sentiment data are better than daily sentiment data in predicting daily stock returns, and the sentiment in non-trading hours has been proved superior to those in trading hours.Originality/valueFirst, our study adds to the growing literature on investor sentiment. We are the first to construct a proxy for high-frequency investor sentiment using intraday postings collected from Chinese Internet stock forum. Second, we confirm that sentiment in non-trading hours has a stronger predictive ability than those in trading hours. Third, we also contribute to the performance comparison of MIDAS-class models. The good performance of U-MIDAS is confirmed in our empirical applications.
Improved shear strength prediction model for SFRC beams without stirrups
Authors: Ahmad Shoaib , He Liusheng 
Published: December 2024

PurposeThe application of steel fiber reinforced concrete (SFRC) beams is limited in practice, partially due to the lack of accurate shear strength prediction models. This study aims to develop a reliable shear strength prediction model for SFRC beams.Design/methodology/approachIn this study, an artificial neural network was employed to predict the shear strength of SFRC beams, utilizing a comprehensive database of 562 experimental studies. Multiple neural networks were established with varying hyperparameters, and their performance was evaluated using statistical parameters.FindingsThe neural network with 11 neurons showed superior results than other networks. The performance evaluation, efficiency and accuracy of the selected neural network were examined using margin of deviation, k-fold cross-validation, Shapley analysis, sensitivity analysis and parametric analysis. The proposed artificial neural network model accurately predicts the shear strength and outperforms other existing equations.Originality/valueThis research contributes to overcoming the limitations of existing prediction models for shear strength of SFRC beams without stirrups by developing a highly accurate model based on ANN. Utilizing a comprehensive database and rigorous evaluation techniques enhances the reliability and applicability of the proposed model in practical engineering applications.