bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 Among Doctors in Indonesia: Risk of Moderate-Severe and Behavior Adaptation in Personal Protective Equipments Usage After Infection
Authors: Yunihastuti Evy , Syam Ari Fahrial , Herikurniawan Herikurniawan , Soemarko Dewi Sumaryani , Wiraguna Andrian 
Published: October 2021

Abstract
Doctors have a greater risk of acquiring COVID-19 due to occupational exposure. Personal protective equipment (PPE) is an essential factor in reducing COVID-19 transmission. We aimed to evaluate the risk of moderate-severe COVID-19 infection and behavior adaptation in PPE usage among doctors who survived COVID-19 in Indonesia. This was an online population-based cross-sectional survey among Indonesian doctors of COVID-19 survivors. Bivariate and multivariate analyses were performed to determine factors associated with moderate-severe COVID-19 infection. A total of 389 doctors who survived COVID-19 infection across in Indonesia was included in this study. Most participants were young doctors (20-39 years: 69.7%), general practitioners (50.4%), working in COVID-19 designated hospitals (62.5%), and worked more than 40 hours/week (57.8%). Factors associated with moderate-severe COVID-19 were IMA moderate occupational risk (aOR 4.14, 95% CI: 1.11-15.47), age 40-59 years (aOR 3.24, 95% CI: 1.99-5.29), working in COVID-19 designated hospital (aOR 1.89, 95% CI: 1.18-3.01), and higher BMI (aOR 1.88, 95% CI: 1.00-3.54). N95 respirator and other PPEs use improved after these doctors recovered from COVID-19 infection in isolation and non-isolation rooms. In conclusion, working COVID-19 designated hospital, moderate occupational risk, higher BMI, and age 40-59 were associated with moderate-severe COVID-19 among doctors in Indonesia.
Productivity Boost – Five-Wave Longitudinal Study on Social Media Invasion Before and During COVID-19
Authors: Oksa Reetta , Pirkkalainen Henri , Salo Markus , Savela Nina , Oksanen Atte 
Published: October 2021

Abstract
The balance between work and private life has become vague due to the use of social media and flexible working conditions. The study drew from technostress and wellbeing literature and examined the behavioral and psychological outcomes of professional social media invasion, the perception that work-related social media usage interferes with one’s private life. Nationally representative five-wave survey data of Finnish employees (n = 840) were analyzed with hybrid liner regression analysis. Results showed an increase of social media-enabled productivity during the COVID-19 pandemic in Spring 2020 – Spring 2021. Professional social media invasion was associated with both within-person and between person effects on social media-enabled productivity. Additionally, work engagement was associated with within-person and between person effects. Higher educated and individuals with open personality reported higher social media-enabled productivity. We challenge the dominant view that professional social media invasion is solely a negative factor. Instead, perceived social media-enabled productivity should be recognized in organizations.
Epithelial–mesenchymal Transition Phenotype and Peritumoral Immune Cell Infiltration in Advanced Biliary Tract Cancer
Authors: Oh Chung Ryul , Kim Hyung-Don , Ryu Yeon-Mi , Lee Seonmin , Kim Danbee , Lee Da Sol , Jeong Jae Ho , Chang Heung-Moon , Ryoo Baek-Yeol , Kim Kyu-pyo , Kim Miyeon , Kim Sang-Yeob , Yoo Changhoon 
Published: October 2021

Abstract
BackgroundWe evaluated the clinical implications of epithelial–mesenchymal transition (EMT) markers and peritumoral immune cell infiltration in patients with biliary tract cancer (BTC) treated with gemcitabine plus cisplatin (GemCis).MethodsForty-five patients with advanced BTC who received GemCis were included as the study population. We conducted multiplex immunohistochemistry and examined EMT markers and their correlations with immune cell infiltrate at the invasive tumor margin. Study population was subdivided into two groups: twenty-four patients with overall survival (OS) less than 10 months (short-term survivor group, SS) and 21 with OS of 20 months or longer (long-term survivor group, LS).ResultsThe density of tumor cells expressing epithelial marker E-cadherin (E-cadherin+ CK+) at the invasive tumor margin tended to be higher in the LS group than in the SS group (p = 0.065). The density of tumor cells expressing mesenchymal marker vimentin (vimentin+ CK+) was significantly higher in the SS group than in the LS group (p = 0.021). Accordingly, the density of E-cadherin- vimentin+ CK+ cells was also significantly higher in the SS group (p = 0.020). The density of OX40 expressing cells (OX40+) was significantly higher in the SS group than in the LS group (p = 0.006). The density of vimentin+ CK+ cells was positively correlated with FoxP3+ CD4+ regulatory T-cells (r = 0.29, p = 0.047) and OX40+ cells (r = 0.48, p < 0.001).ConclusionsEMT-related features were enriched in BTC patients with poor survival outcomes and were associated with the immunosuppressive tumor microenvironment.
Do Institutions Moderate the Energy-Growth Affiliation? Evidence from Sub Sahara Africa Countries
Authors: Appiah Michael , Bugri Benjamin Adelwini , Antwi Frank 
Published: October 2021

Abstract
This paper aims to look into the role of institutional quality in regulating energy and growth affiliation. The countries of Sub-Saharan Africa (SSA) are studied from 1990 to 2019. CSD and SH tests were used to verify cross-sectional dependency and slope homogeneity properties. CIPS and CADF were used to investigate stationarity features. The Westerlund bootstrap cointegration test was used to analyze the long-tenure equilibrium affiliation among the variables and confirm cointegration in the extended period. To examine the long-short term performance between the variables, the CS-ARDL approach is used. To analyze the flow of causation, the study used the DH causality process. The findings reveal that energy has a negative and significant impact on growth. In both terms, industrialization and population have a negative and positive impact on growth, respectively. The DH heterogenous causality study reveals the mixed effect, i.e. one-way causal associations between growth and institutional quality, two-way causal associations between energy and population, and no causation with industrialization. Furthermore, institutional quality as a moderating variable harms growth. To achieve long-period growth, states should expand investment in renewable energy sectors, create well-resourced institutions, and plan for renewable energy development, according to this empirical research.
Co-Transplantation of Marginal Mass Allogeneic Islets with 3D-Culture-Derived Adult Human Skin Cells Improves Glycemia in Diabetic Mice
Authors: Oliveira Talita C. , Forni Maria F. , Santos Ancély F. , Wailemann Rosangela A. M. , Terra Leticia F. , Andreone Luz , Gomes Vinicius M. , Silva Janaina Macedo , Rosa-Fernandes Livia , Sogayar Mari C. , Palmisano Giuseppe , Labriola Leticia , Perone Marcelo J. 
Published: October 2021

Abstract
Background. Pancreatic islets transplantation represents a promising therapeutic option for severe type 1 diabetes (T1D). Maintenance of long-term viability of transplanted islets still requires improvement. Stem cell use represents an option to repair and replace damaged islets or, alternatively, b cells in T1D. Mesenchymal stem cells (MSC) have been proposed as adjuvants for islet transplantation, facilitating grafting and improving their functionality. Aggregation of stem cells has gained interest in providing physiological interactions between cells and enhancing the in situ concentration of modulators of inflammation and immunity.Methods. We established a hanging-drop culture by the spontaneous aggregation of adult human skin fibroblast-like cells as spheroids. Adult skin spheroid-derived cells (SphCs) were characterized in vitro and in vivo. We assessed the potential benefit of SphCs as adjuvants to improve islet functionality by cotransplantation with a marginal mass of allogeneic islets in an experimental diabetic mouse model. We characterized the secretome of SphCs by mass spectrometry-based proteomics.Results. SphCs were characterized as multipotent progenitors by their surface expression of markers analyzed by flow cytometry and multilineage germ differentiation capacity. Coculture of SphCs with anti-CD3-stimulated mouse splenocytes diminished the proliferation of T-CD4+ lymphocytes and biased splenocyte cytokine secretion through an increase in the Th2/Th1 ratio. SphCs conditioned media attenuated apoptosis of islets induced by inflammatory cytokine challenge in vitro. Administration (i.t.) of SphCs showed the absence of tumorigenicity in immune-deficient mice.SphCs improved glycemic control when cotransplanted with a marginal mass of allogeneic islets in an experimental diabetic mouse model without pharmacological immunosuppression. SphCs’ protein secretome differed from its paired skin fibroblast-like counterpart in containing 70% of up- and downregulated proteins and biological processes that overall positively influence islets such as cytoprotection, cellular stress, metabolism, and survival.Conclusions. Hanging-drop cell culture methodology might contribute to the development of an efficient way to improve transplantation outcome by reducing undesirable consequences of pharmacological immunosuppression as well as the number of allogeneic islets required to achieve normoglycemia in T1D transplanted patients. Further studies might determine whether the identified proteins sustain immunomodulation and/or cytoprotective effects in transplanted allogeneic islets.
Reducing Movement Synchronization to Increase Interest Improves Interpersonal Liking
Authors: Ravreby Inbal , Shilat Yoel , Yeshurun Yaara 
Published: October 2021

Abstract
Synchronization has been identified as a key aspect of achieving mutual goals and enhancing social bonding. While synchronization could be maximized by increasing the predictability of an interaction, such predictability is in tension with individuals’ level of interest, which is tied to the interaction’s complexity and novelty. In this study, we tested the interplay between synchronization and interest. We asked 104 female dyads to play the Mirror Game, in which they were instructed to move their hands as coordinately as possible, and then report how much they liked each other. Utilizing information theory and video processing tools, we found that a combination of movement synchronization and complexity explained liking almost two times better than movement synchronization alone. Moreover, we found that people initiated novel and challenging interactions, even though they paid a price – being less synchronized. Examining the interactions’ dynamics, we found that people who liked each other moved in a more synchronized, complex, and novel manner during most of the interaction. This suggests that in addition to synchronization, maintaining interest may be critical for positive social bonding. Thus, we propose a new framework in which balancing synchronization and interest, rather than merely maximizing synchronization, optimizes the interaction quality.
Clinical implications of device-detected atrial fibrillation in cardiac resynchronization therapy
Authors: Yoon Minjae , Oh Jaewon , Chun Kyeong-Hyeon , Yu Hee Tae , Lee Chan Joo , Kim Tae-Hoon , Pak Hui-Nam , Lee Moon-Hyoung , Joung Boyoung , Kang Seok-Min 
Published: October 2021

Abstract
Atrial fibrillation (AF) is associated with decreased cardiac resynchronization therapy (CRT) benefits compared to sinus rhythm (SR). Effective biventricular (BiV) pacing is a determinant of CRT success, but AF can interfere with adequate BiV pacing and affect clinical outcomes. We investigated the effect of device-detected AF on clinical outcomes and optimal BiV pacing in patients with heart failure (HF) treated with CRT. We retrospectively analyzed 174 patients who underwent CRT implantation between 2012 and 2019 at a tertiary center. The average BiV pacing percentage was obtained from the last available interrogation, and the optimal BiV pacing percentage was defined as ≥98%. Device-detected AF was defined as an atrial high-rate episode ≥180 beats per minute lasting more than 6 minutes during the follow-up period. We stratified the patients with SR at pre-implantation into device-detected AF and no-AF groups. A total of 120 patients had SR at pre-implantation, and 54 had AF. Among the SR patients, 19 (15.8%) showed device-detected AF during a median follow-up of 25.1 months. The proportion of optimal BiV pacing was significantly lower in the device-detected AF group than in the no-AF group (42.1% vs. 75.2%, P = 0.009). The device-detected AF group had a higher incidence of HF hospitalization, cardiovascular death, and all-cause death than the no-AF group. The device-detected AF and previous AF groups showed no significant differences regarding the percentage of BiV pacing and clinical outcomes. For HF patients implanted with CRT, device-detected AF was associated with lower optimal BiV pacing and worse clinical outcomes than no-AF.
Synthesis, Characterization and Cytoxicity Evaluation of Syzygium Aromaticum L. Bud (Clove) Essential Oil Nanoemulsion
Authors: Abadi Atena Vafaei Malek , Karimi Ehsan , Oskoueian Ehsan , Mohammad Ghasem Rahimi Kalateh Shah , Shafaei Negin 
Published: October 2021

Abstract
Background: The present study performs to improve the medicinal properties of Syzygium Aromaticum L by processing S. Aromaticum L. Bud essential oil (SABE) to the Nano Emulsion drug delivery system (SABE-NE) and investigate its anti-tumor and apoptotic impacts on human HT-29 colon cancer cells and to evaluate the toxicity of SABE-NE. Applying the ultra-sonication method and characterization by DLS and FESEM analysis facilitates the nano-emulsification procedure. Then both human cancer (HT-29) and normal (HFF) cell lines were evaluated based on the SABE-NE apoptotic and cytotoxic impacts. In an in-vitro section, flow cytometry method, Cas3 gene profile, AO/PI cell staining, and MTT assays apply to analyze the apoptotic and cytotoxic activities, and in further analysis measuring liver lipid peroxidation and antioxidant genes expression (SOD, CAT, and GPx) investigate in mice organs alterations. Result: As a result, produced 131.2 nm SABE-NE induces apoptosis response and cellular death (Cas3 up-regulation and enhanced SubG1 peaks), and subsequently, the HT-29 cells' viability can reduce significantly, while HFF cells indicate confined cytotoxic impacts. Moreover, in-vivo test results on mice liver demonstrate the cytoprotective properties of SABE-NE (reduced lipid peroxidation and increased antioxidant enzymes gene expression and non-detectable cytotoxic impacts).Conclusion: We produced a novel nature nanoemulsion drug delivery system called SABE-NE, which is cell-specific apoptotic inducer and thus can be utilized as an efficient anti-cancer compound for human colon cancer treatment. However, to verify and approve its cell-specific anti-tumor activity, further supplementary studies are required.
Amplitude of Somatosensory Evoked Potentials (SEPs) in Short-Latency SEPs Condition is 80% of that in Giant SEPs
Authors: Demura Ai , Demura Yutaka , Sato Kazuaki , Kinoshita Masako 
Published: October 2021

Abstract
The recording conditions of somatosensory evoked potentials (giant SEPs) are different from those of short-latency SEPs (SSEPs). We investigated the waveform characteristics obtained for each condition. Forty-eight upper limbs of 24 adult normal subjects (12 males, age 35.5 ± 9.7 years (mean ± SD)) were investigated. The main differences in recording conditions were reference electrodes (giant SEPs: the earlobe electrode ipsilateral to the stimulated limb, SSEPs: Fz), stimulus rate (1 Hz, 5 Hz), and bandpass filter (1 Hz–1 kHz, 20 Hz–3 kHz). SEPs were elicited by unilateral percutaneous electrical stimulation of the median nerve at the wrist. The amplitudes of N20o–N20 and N20–P25 were significantly larger in the giant SEP condition than in the SSEP condition (p<0.001). The mean + 3SD of N20–P25 amplitude was 10.0 µV in the giant SEP condition and 7.8 µV in the SSEP condition. The N20–P25 amplitude was significantly correlated between the giant SEP and SSEP conditions (R=0.64, p<0.001). Thus, the amplitude of SEPs in the SSEPs condition is equivalent to 80% of that in the giant SEPs condition. The information is useful for detecting cortical hyperexcitability in various neurological disorders including myoclonic epilepsy.
Rainfall spatial variability in the application of Catchment Morphing for ungauged catchments
Authors: Zhang Jun , Han Dawei , Dai Qiang 
Published: October 2021

Abstract
Catchment Morphing (CM) is a newly proposed approach to apply fully distributed models for ungauged catchments and has been trialled in several catchments in the UK. As one of the most important input datasets for hydrological models, rainfall spatial variability is influential on the stream variabilities and simulation performance. A homogenous rainfall was utilized in the previous experiments with Catchment Morphing. This study applied a spatially distributed rainfall from CEH-GEAR rainfall dataset in the morphed catchment for ungauged catchments as the follow-on study. Three catchments in the UK were used for rainfall spatial analysis and CEH-GEAR rainfall data were adopted for additional spatial analysis. The results demonstrate the influence of rainfall spatial information to the model performance with CM and illustrate the ability of morphed catchment to deal with spatially varied information. More spatially distributed information is expected to be introduced for a wider application of CM.
Política linguística nacional na escola Yanomami
Authors: Simas Hellen Cristina Picanço , Pereira Regina Celi Mendes 
Published: October 2021

Neste artigo discutimos sobre os principais fatores que caracterizam a implementação da Política Linguística Nacional relacionada ao desenvolvimento do ensino de línguas nas escolas indígenas. Para tanto, utilizamos dados advindos de observações realizadas na Escola Estadual Indígena Imaculada Conceição, localizada na comunidade yanomami da região de Maturacá, no município de são Gabriel da Cachoeira, estado do Amazonas. O marco teórico que guiou a investigação e análise dos dados pautou-se em discussões sobre as políticas linguísticas nacionais para o ensino de línguas indígenas e as reflexões que as problematizam e analisam, evidenciadas no Referencial Curricular Nacional para as Escolas Indígenas (1998) e nos trabalhos de Cavalcante & Maher (2005); D’Angelis (2005), Monte (1994) e também nas contribuições sobre política linguística de Calvet (2007), Haugen (1966) e Heinz Kloss (1967). Os resultados apontam que são cinco os fatores que dificultam a implantação da Política Linguística Nacional: o desconhecimento da realidade sociolinguística da comunidade ou, ou, ainda que esta seja reconhecida, não é levada em consideração durante a elaboração de projetos voltados para o ensino de línguas; letramento em comunidade ágrafa; supervalorização do ensinoaprendizagem da escrita em língua portuguesa e em língua yanomami; alfabetização sendo feita primeiramente em língua portuguesa e falta de material escrito em língua yanomami.
Classes fonológicas e ortografia infantil
Authors: Chacon Lourenço , Paschoal Larissa , Vaz Suellen , Pezarini Isabela de Oliveira 
Published: October 2021

A proposta mais geral do presente trabalho é verificar em que medida aspectos das diferentes classes fonológicas estão relacionados a pontos de maior facilidade ou dificuldade na ortografia infantil. Para verificar os efeitos dessa relação, o desenvolvimento do trabalho foi orientado pelos seguintes objetivos: (1) descrever o desempenho ortográfico de crianças quanto ao registro de consoantes do Português Brasileiro; (2) verificar se o acento influencia a ocorrência de erros no interior das palavras; e (3) caracterizar o padrão da distribuição dos erros. Os dados foram extraídos de 866 textos de 76 crianças que, em 2001 e 2002, frequentavam a primeira e a segunda série do ensino fundamental de uma escola pública de um município do interior paulista. Todos os grafemas que remetiam às classes das consoantes oclusivas, fricativas e soantes, situados no ataque silábico simples, foram classificados em acertos e erros. Em seguida, os erros foram organizados conforme ocorressem em sílabas acentuadas, ou não. Posteriormente, foram distribuídos em categorias que os organizavam conforme correspondessem a omissões, substituições ortográficas não-fonológicas, substituições ortográficas fonológicas e híbridos. Como resultados, verificou-se que: (a) os acertos predominaram sobre os erros; (b) a quantidade de erros, bem como seus diferentes tipos, variaram em função da classe fonológica a que remetiam; e (c) os erros não sofreram influência direta do acento. Esses resultados apontam para uma alta estabilidade na aquisição da escrita – portanto, para o sucesso de práticas de letramento que favorecem a alfabetização. Apontam, também, para relações não-simétricas entre características das classes fonológicas e a ortografia das diferentes classes – não-simetria que chama a atenção para os diferentes estatutos que tanto erros quanto acertos podem adquirir na aquisição da ortografia.
Identification Osteogenic Signaling Pathways Following Mechanical Stimulation:
A Systematic Review
Authors: Khojasteh Arash , Nokhbatolfoghahaei Hanieh , Rad Maryam Rezai , Paknejad Zahrasadat , Ardeshirylajimi Abdolreza 
Published: October 2021

Introduction:
It has been shown that mechanical forces can induce or promote osteogenic
differentiation as well as remodeling of the new created bone tissues. To apply this characteristic
in bone tissue engineering, it is important to know which mechanical stimuli through which
signaling pathway has a more significant impact on osteogenesis.

Methods:
In this systematic study, an electronic search was conducted using PubMed and Google
Scholar databases. This study has been prepared and organized according to the preferred reporting
items for systematic reviews and meta-analyses (PRISMA) guidelines. Included studies were first
categorized according to the in vivo and in vitro studies.

Results:
Six types of mechanical stresses were used in these articles and the most commonly used
mechanical force and cell source were tension and bone marrow-derived mesenchymal stem cells
(BMMSCs), respectively. These forces were able to trigger twelve signaling pathways in which
Wnt pathway was so prominent.

Conclusion:
1) Although specific signaling pathways are induced through specific mechanical
forces, Wnt signaling pathways are predominantly activated by almost all types of force/stimulation,
2) All signaling pathways regulate expression of RUNX2, which is known as a master regulator
of osteogenesis, 3) In Tension force, the mode of force administration, i.e, continuous or noncontinuous
tension is more important than the percentage of elongation.