bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Food Allergy in Egyptian Patients complaining of food adverse events attending allergy clinic at Ain Shams University Hospitals
Authors: Yousif Zeinab A , Mohammed Manar F , Zakaraya Dahab N 
Published: October 2021

Abstract

Background
Food allergy is defined as an immune reaction to proteins in the food and can be immunoglobulin (Ig)E-mediated or non–IgE-mediated. IgE-mediated food allergy is a worldwide health problem that affects millions of persons and numerous aspects of a person’s life. Allergic reactions secondary to food ingestion are responsible for a variety of symptoms involving the skin, gastrointestinal tract, and respiratory tract. While all other non-allergic food reactions are categorized as “food intolerance”.

Aims
to assess prevalence of Food allergy among Egyptian patients complaining of food adverse events attending Allergy clinic at Ain Shams University Hospital.

Methods
This was a randomized cross sectional study involving 200 patients complaining of food adverse events attending Allergy clinic at Ain Shams University Hospitals between the first of February 2019 till the end of January 2020, 90 patents had confirmed food allergy

Results
The Total patients who were presented to the Allergy outpatient clinic at Ain Shams University hospital between the first of February 2019 and the end of January 2020 were 200 patients presented complaining of food adverse events with the percentage (9.5%). Among the 200 patients presented complaining of food adverse events, there were 90 patients who were confirmed food allergy.

Conclusion
food allergy may be over estimated along patient with food adverse events.
Correlation between adiponectin level and the degree of fibrosis in patients with NAFLD
Authors: Youssef Tarek Mohammed , Mohamed Manal Sabry , Ahmed Ahmed El-Metwally , Abdullah Esraa Ebrahim 
Published: October 2021

Abstract

Background
Non-alcoholic Fatty Liver Disease (NAFLD) is one of the most prevalent chronic liver diseases particularly in Egypt. It is defined as accumulation of lipids inside the hepatocytes, in absence of other etiologies of hepatic damage. It is frequently associated with obesity, diabetes mellitus and metabolic syndrome.

Objective
To find out the correlation between the degree of liver fibrosis in Non-alcoholic Fatty Liver Disease patients and their serum Adiponectin level as a future non-invasive method for assessment of liver fibrosis to substitute liver biopsy to avoid its hazardous complication. Also to study the correlation between diabetes mellitus as well as obesity and serum Adiponetctin level.

Patients and Methods
50 patients were selected to participate in our study based on our inclusion criteria. They were recruited from the Internal Medicine department, Gastro-intestinal clinic in AlDemerdash Hospital using a convenient sampling method. Diagnoses of NAFLD (Non-alcoholic fatty liver disease) was confirmed by laboratory markers (AST, ALT, Lipid profile), ultrasound as well as fibroscan examination.

Results
Analyzing adiponectin levels showed that -besides its significant correlation with BMI, hypertension, diabetes mellitus and dyslipidemia- it was significantly lower in high grade fibrosis group compared to low grade fibrosis group with P-value of (0.000) and a cutoff value for stage 3/4 fibrosis of about 2.31μg/ml which marked a promising hope of adeponictin being of protective value against liver fibrosis. However, more studies performed on populations of different sizes and characteristics are recommended to allow more accurate generalization of the results and hopefully exploring a new horizon for the follow up and treatment of patients with chronic liver disease especially NAFLD.

Conclusion
Adiponectin is an abundant adipocyte-derived protein with well-established antiatherogenic, insulin-sensitizing and anti-inflammatory properties. The liver is a major target organ for adiponectin especially in fatty liver diseases and this adipocytokine has the ability to control many liver functions including metabolism, inflammation and fibrosis. Both serum levels and hepatic adiponectin receptor expression are decreased in NAFLD. Therefore, either adiponectin itself or adiponectin-inducing agents might be of key therapeutic interest in the near future in the treatment of NAFLD.
Role of Aspergillus fumigatus sensitization in Patients with Asthma- COPD Overlap compared to asthma patients
Authors: Elshayeb Mohamed Abd El Rahman , Abd el Sayed Sylvia Talaat Kamal , Ahmed Noha Othman , Elsaeed Ahmed Moustafa Mahetab Hany 
Published: October 2021

Abstract

Background
Distinguishing asthma from COPD can be difficult especially among old age and smokers. Some patients have common features of asthma and COPD.1 (GINA, 2018). Hence, the definition of asthma COPD overlap (ACO) was developed. ACO is a considerable risk factor for healthcare utilization versus the general population, the asthma population and the COPD population.2(Minchul Kim et al., 2019). Fungal sensitization increase severity of asthma.

Aim of the study
To compare the prevalence of aspergillus fumigatus sensitization among ACO patients versus asthmatic patients and healthy normal control.

Patients and Methods
90 individuals were included; 30 diagnosed as bronchial asthma
(According to GINA 2018), 30 ACO patients and 30 healthy normal control. All are group matched to age and sex and selected from the allergy and chest outpatient clinics at Ain shams University hospitals. Total IgE, skin test for Aspergillus and spirometry were done to all participants.

Results
Aspergillus sensitization was more prevalent among ACO group compared to asthma group however, all control individuals were negative to aspergillus. FEV1 was significantly lower among ACO and asthma groups when compared to control. FEV1 increased significantly in the three groups after albuterol inhalation.

Conclusion
sensitization to Aspergillus was more among ACO patients compared to Asthma and control groups.
Role of serum M2BPGi levels in diagnosing significant liver fibrosis and cirrhosis in patients with chronic hepatitis B
Authors: William Keddeas Marcel , Haroun Kaisar Hany , Ahmed Elessawy Hagar Ahmed , Abdel Hamid Elewa Mariam Samir 
Published: October 2021

Abstract

Background and aim
Mac-2-binding protein glycosylation isomer (M2BPGi) is a novel serum diagnostic marker for liver fibrosis in various liver diseases. We aimed to evaluate its role in assessment of liver fibrosis in chronic hepatitis B infection (CHB) with reference to liver stiffness measurement (LSM) by transient elastography (Fibroscan).

Design and Methods
A case control study. 50 CHB patients with LSM by transient elastography technology and retrievable serum samples and 20 normal volunteers as a control group were recruited.

Results
50 CHB patients (M: F = 30:20; mean age 43years ± 10.58) and 20 normal control volunteers (M: F = 12:8; mean age 37years ± 14.5) were recruited. The mean M2BPGi values for control group, F0-F1, F2, F3 and F4 progressively increased with more advanced stages of liver fibrosis: 0.282, 0.719, 1.322, 1.65 and 1.904 COI, respectively (p &lt; 0.001). M2BPGi levels correlated well with liver stiffness (r = 0.911) and moderately with FIB-4 (r = 0.682), and with APRI (r = 0.536) (all p &lt; 0.001). Using cut-off values of 0.455, 1.02, 1.16, 1.66 and 1.71COI for control, F0-F1, F2, F3 and F4 groups, respectively, the AUROCs were 0.996, 0.996, 0.691, 0.794 and 1.00 for control, F0-F1, F2, F3 and F4 groups, respectively. There was a statistically significant but with weak positive correlation between M2BPGi serum level and INR (r = 0.333, p = 0.018). And there was a statistically significant but with weak negative correlation between M2BPGi serum level and platelet count (r = -0.41, p = 0.003) and HBV DNA (r = -0.373, p = 0.008).There was a statistically significance between M2BPGi serum level and the history of varices (p = 0.023)

Conclusions
WFA+-M2BP is an accurate serum indicator for assessing different stages of liver fibrosis. WFA+-M2BP provides a simple and reliable alternative or complementary method to liver biopsy and FibroScan.
Serum Dickkopf-1 as a diagnostic & prognostic marker for Hepatocellular Carcinoma
Authors: Foda Enas Mahmoud , Mansour Khaled Amr , Hashem Walaa Mohamed , Ali Nancy Zakaria 
Published: October 2021

Abstract

Background
Hepatocellular carcinoma (HCC) is the fifth most common malignancy and the second leading reason of cancer-associated deaths around the world.The poor outcome of patients with HCC is attributed to late detection, with more than two-thirds of patients diagnosed at advanced stages of the disease. However, a considerable improvement in survival has been observed (5-year survival up from 40% to 70%) when patients are diagnosed at an early stage and receive potentially curative therapy in the form of liver transplantation, surgical resection, or tumor ablation.

Objective
Evaluate levels of serum Dickkopf-1, & its significance as a diagnostic & prognostic marker for Hepatocellular Carcinoma.

Aim of the work
assess the possible diagnostic role of serum DKK1 compared to alpha- fetoprotein which is the slandered marker used for diagnosis of HCC.also DKK1 act as prognostic marker for Hepatocellular Carcinoma.

Pateints and Methodes
This study had been carried out on 45 subjects diveded into 2 groups,first group include 30 pateints with liver cirrhosis,and second group 15 pateints with HCC.In this group of patients DKK1 was withdrawn before TACE & 3 months post intervention, age range 25-73 year selected from Internal medicine and Hepatology outpatient clinics and inpatient wards at Ain shams university hospitals from March 2019 till January 2020.They were distributed as 25 males and 20 females. There were 13 pateints with child A,17 pateints with child B, & 15 pateints (20%) with child C.

Results
In this study, the serum levels of serum DKK1 were highest in patients with HCC compared to those with liver cirrhosis. Also DKK1 values significally decreased after intervention(TACE).

Conclusion
Serum DKK1 act as a diagnostic marker for HCC and its level significally decrease after TACE
Assessment of Magnesium level Among Hemodialysis Patients and Its Relation to Vascular Stiffness
Authors: Zaki Mahmoud , Khedr Abdel Rahman , Hassan Ashraf , Fattah Nouran Abdel 
Published: October 2021

Abstract

Background
The pathogenesis of vascular calcification in Chronic kidney disease (CKD) patients is multifactorial and complicated. It has been proposed that Magnesium (Mg) may be implicated in the process of vascular calcification on various levels.

Aim
This study aims to assess the level of magnesium in hemodialysis patients and its relation to the vascular stiffness.

Patients and methods
100 prevalent hemodialysis patients were included in the study and they were clinically stable with absence of cardiovascular complications, all patients underwent the following laboratory investigation including complete blood picture, median of magnesium level over 3 months, electrolytes, ipth, lipid profile and radiological investigations including transthoracic echocardiography and carotid duplex.

Results
The studied population was divided into two groups, group I included 68 patients with normal mg level and group II included 32 patients with low mg level. There was statistically significant difference between the two groups as regard hemoglobin level (pvalue=0.033), otherwise there was no statistically significant difference as regard other laboratory and radiological investigations. Then they were divided into another two groups according to the presence of mitral valve calcification (MVC), group III involved 85 patients without MVC and group IV involved 15 patients with MVC. There was statistically significant difference between 2 groups as regard aortic wave pulse velocity (aPWV) with (pvalue=0.002), presence of plaques with (pvalue &lt;0.001) and intimal media thickness with (pvalue&lt;0.001). Another group was divided according to presence of aortic valve calcification (AVC) into two groups, first group V included 39 patients without AVC and second group VI included 61 patients with AVC. There was statistically significant difference between two groups as regard age with (pvalue&lt;0.001), ipth with (pvalue=0.033), presence of plaques with (pvalue=0.048) and intimal media thickness with (pvalue&lt;0.001).

Conclusion
There was high prevalence of vascular calcification among hemodialysis patients which may be related to age and hyperparathyroidism but without statistically significant correlation to Mg level.
Serum Leptin in correlation to clinical severity in patients with chronic urticaria
Authors: Farres Mohamed N , El khoderee Mayada M , ELkady Hossam M , Eissa Nouran M 
Published: October 2021

Abstract

Background
Chronic urticaria (CU) is a complex disease associated with a systemic inflammatory response. This inflammation could be related to the release of adipokines with proinflammatory properties such as leptin. In recent years, leptin has been associated with different diseases, wound healing and immune cell activation.

Objective
to evaluate leptin levels in patients with chronic spontaneous urticaria, to investigate the possible role of leptin in chronic spontaneous urticaria pathogenesis and to outline relationships between serum leptin and urticaria severity.

Methods
A case-control study was conducted at the allergy and immunology outpatient clinic at Ain Shams University hospital, and included 60 patients with chronic spontaneous urticaria and 30 healthy individuals who were group matched with cases for age and sex serving as the control group. All the patients were subjected to the following: Full history, clinical examination, calculation of body mass index (BMI), CBC, ESR, CRP, Thyroid profile, AST, ALT, Skin prick test or Specific IgE for common allergens, and measurement of serum leptin level after overnight fasting by ELISA.

Results
The present study showed that patients with chronic spontaneous urticaria had higher level of serum leptin in comparison to control subjects and there was a positive correlation between leptin level and urticaria severity which was assessed by urticaria activity score.

Conclusion
serum leptin is increased in chronic spontaneous urticaria and it is positively correlated to urticaria severity.
Assessment of Minimal Residual Disease in Multiple Myeloma patients undergoing Autologous Stem Cell Transplant using Multiparameter Flow Cytometry
Authors: Mostafa NN , El-Salakawy WA , Abdelbary HM , Radwan RA , Fathy RK , Aboelmagd YA 
Published: October 2021

Abstract

BACKGROUND
Multiple Myeloma (MM) is still considered an incurable relapsing disease, despite major advances in multidrug combinations, incorporation of autologous transplant and achieving higher rates of CR. This suggests persistent presence of residual disease, not detected by current techniques. Minimal residual disease (MRD) monitoring by multiparameter flow cytometry (MFC) is a powerful tool to quantitatively measure residual disease and allow tailoring of the management plan on individual basis.

AIM
To assess the value of MRD by MFC in determining the efficacy of treatment, monitoring depth of remission and predicting impending relapse.

PATIENTS AND METHODS
We included 33MM patients, who were candidates for ASCT in this prospective study. MFC (with a 0.01% limit of detection) on a BM aspirate obtained before transplant and at day 100 post-transplant, was used to measure MRD for all patients. Patients were then later assessed for progression 1-year post-transplant.

RESULTS
MRD status at 100 days post-transplant was strongly related to the risk of 1-year post-transplant progression (p-value 0.001), and by using a ROC curve, we found that MRD (%) at 100 days post-transplant can predict progression after 1 year with a best cutoff value ≥ 0.04 achieving a 75% sensitivity and 81.2% specificity. On dividing the patients according to their MRD status before and after transplant, group 3 who were MRD positive pre- and post-transplant, had a high risk of progression 1year post-transplant (p-value 0.003). The use of bortezomib-based regimens resulted in a deeper response and a more negative MRD pre-transplant (p-value 0.01), that was maintained post-transplant. Also, ASCT resulted in the development of deeper remission (p-value 0.004) and more MRD negativity (p-value 0.02).

CONCLUSION
we recommend the use of MRD by MFC as a powerful prognostic tool that should be incorporated in routine myeloma workup.
Predictive value of serum chemerin and nafld fibrosis score to ultrasonographic detection and quantification of steatosis in nonalcoholic fatty liver disease patients
Authors: Byoumy Essam Mohamed , Mohamed Azza Imam , Ibrahim Wesam Ahmed , El-Shafie Ahmed Ibraheem Mohamed , Salama Mohamed Magdy , Ibrahim Mohamed El-Sayed Abd-Aullah 
Published: October 2021

Abstract

Background
It is difficult to diagnose spontaneous bacterial peritonitis (SBP) early in ascitic patients. Procalcitonin (PCT) is inflammatory marker used to diagnose severe bacterial infections. We evaluated the diagnostic role of this marker for spontaneous bacterial peritonitis (SBP) associated with liver cirrhosis.

The aim of the study
was to measure serum procalcitonin (PCT) levels to obtain an early diagnostic indication of SBP in ascitic patients.

Methods
A total of 90 patients diagnosed with liver cirrhosis devided in to three groups: Group (A):including 30 patients with SBP, Group (B) including 30ascitic patients without SBP and Group (C): including 30cirrhotic patients without ascites, groups were compared in terms of procalcitonin levels in predicting ascites infection. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic performance of procalcitonin levels.

Results
Serum procalcitonin levels were determined to be significantly higher in patients with SBP compared to patients without SBP (median (min-max): 0.93 (0.4 - 1.23)vs. 0.13 (0.08 - 0.2), p = 0.100). Using ROC analysis, a serum procalcitonin level of &gt; 0.315ng/mL (area under curve (AUC): 0.919, sensitivity: 87%, specificity: 97%, positive predictive value 96% and negative predictive value 88%) were determined to accurately help the diagnosis of spontaneous bacterial peritonitis.

Conclusion
According to our findings, determination of serum procalcitonin levels seems to provide accurate and rapid diagnosis of ascitic fluid infection.
Relationship of serum vaspin, nafld fibrosis score to ultrasonographic detection and quantification of steatosis in nonalcoholic fatty liver disease patients
Authors: Byoumy Essam Mohamed , Sayed Moataz Mohamed , El-Rahman Shereen Abo Baker Abd , Al-Nakib Sara Abd Elkader , Salama Mohamed Magdy , Mohamed Mohamed Gaber Abd El Maksoud 
Published: October 2021

Abstract

Background
Ectopic hepatic lipid accumulation is closely related to the development of insulin resistance, which is regarded as one of the most significant risk factors of non-alcoholic fatty liver disease (NAFLD).

The aim of the study
was to evaluate and validate the diagnostic value of serum vaspin, NAFLD Fibrosis Score and sonograghic parameters in detection and quantification of liver steatosis and determining further need for liver biopsy or other means to establish NAFLD diagnosis.

Methods
This study was carried out on 60 patients having bright liver in ultrasonography and 30 healthy persons as controls. The subjects were divided into the following groups; group A: 30 age and sex matched healthy volunteers (control group), group B: 20 patients with fatty liver grade I, group C: 20 patients with fatty liver grade II and group D: 20 patients with fatty liver grade III.

Results
serum vaspine levels and NAFLD fibrosis score, were significantly higher in patients than in controls with p-value:&lt;0.001. There was a significant positive correlation between NAFLD fibrosis score and serum vaspin and ultrasonographic findngs of NAFLD with p-value: &lt;0.001.

Conclusion
Vaspin seem to be the most suitable non-invasive biomarker in predicting both intrahepatic lipid contents in NAFLD group.
Study of Non-alcoholic fatty liver disease among chronic kidney disease patients by Controlled attenuation parameter
Authors: Salem Mohamed Mahrous , Shawky Sahar Mahmoud , Behairy Maha Abd Elmoneim , Helmy Ahmed Fouad 
Published: October 2021

Abstract

Background/Aim
Preliminary data suggest an association between chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD). The aim of this study was evaluate the frequency of NAFLD and its associated risk factors among nondiabetic CKD patients not on dialysis.

METHODS
A total of 40 subjects were enrolled in the study. Group A (30) Pre dialysis non-diabetic CKD patiens and Group B (10) normal subjects matched for age and sex as a control group. Liver stiffness measurement was used to detect liver fibrosis and CAP (controlled attenuation parameter) was used to detect and quantify liver steatosis (Fibroscan®). NAFLD was defined by CAP values ≥238 dB/m.

RESULTS
Results of the current study showed that CKD stage III was present in 17 patients (56.7%) and CKD stage IV in 9 patients (30%) and CKD stage V in in 4 patients (13.3%). The total frequency of presence of steatosis (CAP values ≥238 dB/m) whatever degree was significantly higher in CKD group than control; More than (53%) of CKD patients have NAFLD, and (30%) of control group have NAFLD. The severity of liver steatosis was negatively correlated with GFR, Hb and HDL, and positively correlated with Creatinine, BUN, CRP, Cholesterol, TG, LDL, SGPT, SGOT, FBG and HBA1C.
There was significant relation between steatosis and CKD etiology. (82.3%) of Patients with hypertension have Steatosis, (33.3%) of Patients with reflux nephropathy have steatosis, (16.7%) of Patients had other causes have steatosis, while patients had renal stones have no steatosis.
There was significant positive correlation between fibrosis degree and age of CKD patients and also significant positive correlation between steatosis and fibrosis among CKD patients. The study showed significant positive correlation between SGPT and fibrosis degree.
The results suggest a high prevalence of NAFLD in non-diabetic CKD patients. The severity of liver steatosis is negatively correlated with kidney function; there was significant correlation between CKD stage and other risk factors of hepatic steatosis
Response of Ns5a inhibitors resistant patients to Qurevo-Sovaldi-Ribavirin regimen as a retreatment strategy for chronic hepatitis c virus infection
Authors: Moanes Ahmed A , Radwan Hesham H , Abd El Rahman Yasser O , Abd El Nabi Mostafa M 
Published: October 2021

Abstract

Background
Hepatitis C Virus (HCV) infection is a major global health challenge; it is estimated that more than 80 million people are chronically infected worldwide, with 3–4 million new infections and 350 000 deaths occurring each year because of HCV-related complications.

Aim of the work
to determine the efficacy of Qurevo-Sovaldi-Ribavirin regimen as a retreatment strategy in NS5A inhibitors (Sofosbuvir & Daclatasvir) resistant patients infected with chronic hepatitis C virus.

Patients and Methods
An observational cross-sectional study was carried out on 20 chronic hepatitis C virus infected patients in The centre of HCV treatment at El Quabary specialized centers in Alexandria where large number of patients receiving their HCV treatment.

Results
all patients (20/20) achieved sustained virological response after 3 months of the last dose of treatment (SVR12).

Conclusion
the new retreatment strategy composed of the triple therapy Qurevo (Ombitasvir/Paritaprevir/Ritonavir)/Sofosbuvir/Ribavirin is effective in the treatment of chronic HCV infected patients previously treated with Sofosbuvir/Daclatasvir/Ribavirin for 12 weeks without achieving sustained virological response (Ns5a inhibitors resistant chronic HCV patients).