bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐Technological Solutions for In‐Store Smart Retailing
Authors: Qiu Xinxin , Roy Sanjit K. , Singh Gaganpreet , Gruner Richard L. 
Published: December 2024

ABSTRACTSmart in‐store technologies are flourishing in retail, encompassing innovations such as smart carts, in‐store mobile applications, and self‐checkouts. Despite their growing coexistence, configuring these technologies throughout the consumer in‐store shopping journey remains underexplored. To address this issue, this study investigates effective multi‐technological solutions that benefit consumers and retailers in grocery store settings from a configurational perspective, focusing on service convenience, shopping value, and retail store image. In Study 1, we developed and tested a research model relating consumer‐oriented benefits (i.e., service convenience and shopping value) and retailer‐oriented benefits (i.e., retail store image) using partial least squares structural equation modelling (PLS‐SEM). In Study 2, fuzzy set qualitative comparative analysis (fsQCA) was used to examine the technology configurations that drive these benefits. Several effective multi‐technological solutions were identified. Results show that smart shopping carts play a central role in driving several benefits, as does their combination with self‐checkouts. Also, the absence of a touchscreen kiosk is identified as a core condition in an ideal shopping experience facilitated by smart shopping carts. The findings offer novel and actionable insights into effective configurational strategies for in‐store technologies in smart retailing practices.
Design, Synthesis, in Silico and in Vitro Dipeptidyl Peptidase‐4 Activity of Triazole‐Based Heterocyclic Compounds
Authors: Kumar Ranjeet , Nidhar Manisha , Tewari Ashish Kumar 
Published: December 2024

ABSTRACT1,2,3‐triazole‐based ring connected with pyridazine, triazine, methyl pyrazole, diphenyl pyrazole, and phthalimide moieties through propylene linker has been synthesized for antidiabetic evaluation via click chemistry. The antidiabetic evaluations have been done by molecular docking studies and in‐vitro tests against the dipeptidyl peptidase‐4 (DPP‐4) enzyme. The molecular docking studies have revealed that compounds 22, 23, 29, and 30 showed hydrogen bonds with the DPP‐4 enzyme while in‐vitro tests have revealed that compound 30 has (IC50 values 12.82 nM), exhibited potent activity compared to the standard drug, sitagliptin (14.8 nM). Among the heterocyclic compounds, phthalimide and pyrazole derivatives were found more potent for DPP‐4 inhibitors.
Essential Oil of Otanthus maritimus (L.) Hoffmanns. & Link From Algeria With High Content in (α/β)‐Isocomene and α‐epi‐Bisabolol
Authors: Benabdelkader Tarek , Neghliz Hayat , Jullien Frédéric 
Published: December 2024

ABSTRACTEssential oils (EOs) are a potential source of biologically active molecules. Knowing exactly the constituents of an EO is fundamental to verifying its quality and predicting its biological potential and toxicity. Thus, the objective of this work is to determine the chemical constituents and the chemotype of the EO of Otanthus maritimus (L.) Hoffmanns. & Link growing wild in Zemmouri (Boumerdes, Algeria). EOs from the aerial flowering parts of two harvests, December and February, of O. maritimus, were isolated by hydrodistillation in a 0.19% and 0.14% yield, respectively. Gas chromatography‐mass spectrometry analysis allows the identification of both EOs 36 constituents representing 87.35%–92.7% of the total oil composition dominated by irregular sesquiterpenes 35.05% and 29.34%, respectively. In the EO of the December harvest, the major compounds were α‐isocomene (15.75%), β‐isocomene (7.92%), artemisyl acetate (6.63%) and α‐epi‐bisabolol (6.16%). Whereas, α‐isocomene (18.73%), artemisyl acetate (9.65%), α‐epi‐bisfabolol (8.96%), germacrene‐D (7.13%) and β‐isocomene (6.63%) were dominant in the EO of February harvest. This is the first report of the α‐isocomene present as the first main component in the EO of this plant in parallel with an exceptional richness in α‐epi‐bisabolol, which has never been detected previously, which justifies that it is another different chemotype of O. maritimus from Algeria.
Prevalence of Neurodiversity in a UK High Secure Psychiatric Hospital Cohort: A Records Study
Authors: Walker Freya , Murphy David , Gröger Laura , Moore Estelle 
Published: December 2024

ABSTRACTBackgroundThe term neurodiversity is an umbrella term for any atypical pattern of cognitive ability, including but not confined to neurodevelopmental disorders. Research suggests that several neurodivergent conditions are overrepresented in offender populations, with a recent survey suggesting that over half of those coming into contact with the criminal justice system may have a neurodivergent condition. Considerable effort has been invested in trying to divert people with such conditions out of long‐stay hospitals, but nevertheless, a few studies in secure hospitals suggest that while prevalence in hospitals may be lower than in prisons, it is high relative to the general population.AimsTo determine the prevalence of recorded neurodivergent conditions in one high secure hospital.MethodsWe conducted a records survey of a resident cohort of men in one high secure hospital in England during December 2022.ResultsRecords were accessed for all 197 resident men. According to these records, over one‐half (115, 58%) of the men had at least one neurodivergent condition; nearly a third (56, 29%) had more than one form of neurodivergent condition. The most frequently recorded form of neurodivergent condition was general cognitive dysfunction (24%), followed by general language difficulties (16%), ADHD (15%) and autism (14%) and those with a history of seizures (14%) and atypical brain scans (12%). Dyslexia was reported within 6.5% of patient notes, acquired brain injury 5% and chromosomal disorders 2%. The survey also suggests some differences in the prevalence of neurodivergent disorders across clinical groups, with higher rates among people with mental illness than with personality disorder. Prevalence was also unevenly distributed across nature of ward type.ConclusionsWith the survey suggesting that the majority of patients in one high secure psychiatric hospital have at least one form of neurodivergent condition, it raises questions around how useful the term is and what the term neurodivergence means in this population. With each form of neurodiversity having different needs, the diversity of conditions present also raises questions around what a ‘neurodiverse informed model of care’ would look like in forensic mental health services.
Comparing FFR‐Guided Complete Revascularization and Conservative Management for Non‐Culprit Lesions in STEMI Patients With Multivessel Disease: A Systematic Review and Meta‐Analysis
Authors: Gonnah Ahmed R. , Awad Ahmed K. , Helmy Ahmed E. , Elsnhory Ahmed B. , Shazly Omar , Abousalima Saad A. , Labib Aser , Saoudy Hussein , Awad Ayman K. , Roberts David H. 
Published: December 2024

ABSTRACTBackgroundIn patients with ST‐segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease, the optimal management strategy for non‐culprit lesions is a subject of ongoing debate. There has been an increasing use of physiology‐guidance to assess the extent of occlusion in non‐culprit lesions, and hence the need for stenting. Fractional flow reserve (FFR) is commonly used as a technique. This analysis compares FFR versus conservative management in the management of non‐culprit lesions in STEMI patients with multivessel disease.MethodsA comprehensive literature search was conducted on databases from inception to May 25, 2024. We conducted a random‐effects meta‐analysis using RevMan version 5.3.0, employing the Der‐Simonian and Laird method to combine the data.ResultsThe analysis of five RCTs including 3759 patients revealed a significantly lower incidence of major adverse cardiovascular events (composite of all‐cause mortality, non‐fatal myocardial infarction and the need for repeat revascularization [PCI or CABG]) in the FFR group compared to the conservative management group (RR = 0.65, 95% CI: 0.44−0.96, p = 0.03). The revascularization rates were significantly lower in the FFR group (RR = 0.53, 95% CI: 0.43−0.66, p < 0.00001). Additionally, unplanned hospitalization leading to urgent repeat revascularization and any cause hospitalization were significantly lower in the FFR group (RR = 0.72, 95% CI: 0.56−0.94, p = 0.01), and (RR = 0.62, 95% CI: 0.46−0.84, p = 0.002), respectively. The FFR group had a higher risk of definite stent thrombosis (RR = 2.26, 95% CI: 1.10−4.64, p = 0.03). No significant differences were observed between the two groups in mortality, hospitalization for heart failure, or myocardial infarction. Similarly, bleeding rates, cerebrovascular accidents (CVAs), and contrast‐induced nephropathy (CIN) were comparable between both groups.ConclusionOur findings support FFR‐guided PCI to manage non‐culprit lesions in STEMI patients with multivessel disease as it is potentially safe, with comparable rates of bleeding, CVAs and CIN. It also improves clinical outcomes, as well as reduces revascularization and hospitalization rates. The risk of stent thrombosis remains a concern, and hence the decision making for FFR‐guided complete revascularization should take into account the complexity/risk of the procedure, as well as the patients' individual co‐morbidities and preferences.
Intracoronary Tissue Plasminogen Activator Therapy to Treat Thrombotic Occlusion of a Giant Coronary Aneurysm in Early Kawasaki Disease
Authors: Patrizio Moras , Mara Pilati , Micol Rebonato , Gianfranco Butera 
Published: December 2024

ABSTRACTKawasaki Disease (KD) is a systemic vasculitis that can lead to coronary artery aneurysms (CAA) in up to 10% of treated cases, significantly increasing the risk of thrombosis and acute myocardial infarction (AMI). While thrombolytic therapy is commonly used in adult coronary syndromes, its application in pediatric KD remains poorly studied. We report a 9‐month‐old infant with KD and giant CAA complicated by a subocclusive thrombus in the left anterior descending artery (LAD). Initial systemic intravenous thrombolysis (IVCT) with alteplase failed to prevent progression to ST‐elevation myocardial infarction (STEMI). Intracoronary thrombolysis (ICT) was subsequently performed, achieving partial reperfusion without complications. At 18 months of follow‐up, the patient remained asymptomatic with stable left ventricular dysfunction. This single case illustrates the potential feasibility of combining ICT and IVCT in managing coronary thrombosis in pediatric KD. However, as a single observation, these findings cannot be generalized, and the approach requires further investigation. Robust multicenter studies are necessary to establish the safety, efficacy, and optimal use of thrombolytic therapy in pediatric KD patients with coronary thrombosis.
Porous Organic Polymers for CO2 Capture and Catalytic Conversion
Authors: Zhong Zicheng , Wang Xiaoyan , Tan Bien 
Published: December 2024

AbstractOveruse of fossil fuels and anthropogenic activities have led to excessive emissions of carbon dioxide, leading to global warming, and measures to reduce atmospheric carbon dioxide concentrations are needed to overcome this global challenge. Therefore, exploring an environmentally friendly strategy for capturing airborne CO2 and converting it into high‐value‐added chemicals offers a promising pathway toward “carbon neutrality”. In recent years, porous organic polymers have attracted much attention for carbon capture and the catalytic conversion of carbon dioxide because of their high specific surface area, high chemical stability, nanoscale porosity, and structural versatility, which make them easy to functionalize. In this review, we introduce the preparation methods for various POPs, the types of POPs adsorbed during carbon dioxide capture, and the progress in the use of POPs for the photocatalytic and chemicatalytic conversion of carbon dioxide, with a special discussion on the influence of adsorption type on the efficiency of catalytic conversion. Finally, we propose a prospective direction for the subsequent development of this field.
Multimodality Imaging Supports Cardiac Lesion Diagnosis in Patient With Liver Carcinoma: A Case Report
Authors: Nguyen Hoa Thi Thuy , Nguyen Yen Thi Hai , Kirkpatrick James N. , Nguyen Viet Khoi , Nguyen Anh Van , Pham Hung Manh , Taylor Walter Robert , Nguyen Hoai Thi Thu 
Published: December 2024

ABSTRACTIntroductionNonbacterial thrombotic endocarditis (NBTE) is a rare cardiac manifestation in patients with advanced malignancies of the lungs, pancreas, gynecological system, and gastrointestinal tract. It is often confirmed postmortem by histopathological evidence of sterile platelet‐fibrin deposits attached to the endocardium, most often on heart valves. To the best of our knowledge, our case is the first to report multiple heart lesions caused by the systemic effect of cholangiocarcinoma.Case PresentationWe report the case of a 53‐year‐old male who presented with a stroke; extensive imaging studies, including transthoracic echocardiography (TTE), 2D/3D transesophageal echocardiography (TEE), cardiac multi‐slice computed tomography, and cardiac magnetic resonance, found masses on the mitral valve, the aortic valve, and in the right ventricle, with the largest diameter 43 × 11 mm, which led to a diagnosis of NBTE secondary to presumed cholangiocarcinoma. Combining different echocardiography techniques, including TTE and TEE in specific clinical contexts, and training echocardiographers to improve TEE interpretation skills could be the most cost‐effective option for early diagnosis, particularly in limited‐resource settings, where advanced imaging modalities are not widely applicable.ConclusionsNBTE can manifest in patients with advanced cancer. A high index of clinical suspicion is of central importance for the diagnosis of NBTE, especially through an identification of the underlying predisposing conditions. A multi‐disciplinary approach is crucial for NBTE optimal diagnosis and treatment. As in our patient, multimodality imaging plays a complementary role in clearly defining the nature of cardiac lesions.
The Open Hand Initiative: Facilitating the Use of Real‐World Evidence in Regulatory Submissions Through Collaboration and Transparency
Authors: Baumfeld Andre Elodie , Gee Matthew , Magnus Carsten , Greeman Stephanie , White Pipper , de Mars Maryellen , Spring Brad 
Published: December 2024

Real‐world data (RWD) collected to generate real‐world evidence (RWE) holds promise for expediting patient and healthcare provider access to new in vitro diagnostics (IVDs) by serving as evidence to demonstrate test performance or utility. However, uncertainties remain for IVD developers (device manufacturers), regulators, and other healthcare stakeholders on the specifics of collecting fit‐for‐purpose RWD and using RWE for regulatory decision‐making. We report on a unique approach to medical device regulatory review called the Open Hand Initiative, by which the US Food and Drug Administration (FDA) and device manufacturers collaborate to ensure the appropriate use of RWD/RWE to support regulatory decision‐making. Normally, regulatory submission interactions are confidential; in the Open Hand approach, device manufacturers share high‐level learnings from pre‐submission interactions to advance the use of reliable and relevant RWD/RWE for regulatory decision‐making. In a pilot study, the Open Hand approach was applied to pre‐submission interactions regarding the use of RWD/RWE for transition of SARS‐CoV‐2 serology IVDs with Emergency Use Authorization (EUA) to full market authorization. Participants in the pilot agreed that the candid discussions were key to identifying barriers to efficient, timely, and robust RWE generation for IVD premarket submissions. The pilot also led to valuable lessons learned around current regulatory requirements for RWE, SARS‐CoV‐2 testing complexities, and the impact that the rapidly evolving COVID‐19 pandemic had on RWD availability and quality. The Open Hand Initiative can be applied more broadly to guide device manufacturers in collecting high‐quality RWD to generate RWE for premarket applications.
Hybrid Switched Inductor‐Capacitor Network–Based High Step‐Down Ratio DC‐DC Converter for On‐Board EV Charger Applications
Authors: Talluri Mahi Teja , Karthikeyan V. , Murugesan Suman 
Published: December 2024

ABSTRACTThe step‐down DC‐DC converter plays a vital role in transformer‐less grid‐connected on‐board EV charging systems, enabling the reduction of voltage to desired levels. This study introduces a novel Hybrid Switched Inductor‐Capacitor Network (HSICN)–based high step‐down ratio DC‐DC converter for on‐board EV charger applications. Compared to recent converter designs, the proposed HSICN achieves an impressive step‐down ratio while minimizing voltage stress on the switch, making it particularly suitable for high‐power applications. Additionally, by distributing the output current between both inductors, the overall volume of magnetic components is reduced, leading to decreased conduction losses. Furthermore, this approach lowers the ripple current in the inductor, contributing to a reduction in the size of passive components. The operational principles of the proposed HSICN, alongside steady‐state analysis, are thoroughly discussed in this study. Moreover, a comprehensive comparative assessment of the proposed converter's performance is provided. To validate its effectiveness, a 500‐W experimental prototype was constructed and analyzed, demonstrating peak experimental efficiency of 95.8% at 350 W.
CFO and PAPR Analysis for Single‐ and Multistream CIFDMA System
Authors: Kumar J. Arun , Stuwart S. Lenty 
Published: December 2024

ABSTRACTThe paper investigates the performance of a cyclic interleaved frequency division multiple access (CIFDMA) system proposed in our earlier works. In our present study, the carrier frequency offset (CFO) and the peak‐to‐average power ratio (PAPR) analysis are done for the proposed CIFDMA, supporting single and multiple data stream transmissions. The proposed system is analyzed without employing any compensation technique needed to alleviate the effect of CFO and PAPR. The CIFDMA delivers superior performance over the conventional IFDMA system under low and moderate CFOs. Besides, the bit error ratio (BER) versus signal‐to‐noise ratio (SNR) performance comparisons for constant and random CFOs reveal the dominance of the proposed system over the conventional system for both single and multiple data stream transmissions. The PAPR performance of the proposed system is superior to the orthogonal frequency division multiple access (OFDMA) system. However, the PAPR of the proposed system escalates by an acceptable margin to that of the conventional system, and the deviation in the PAPR value falls within the acceptable range. The simulation results conclude that the proposed CIFDMA system will better replace the conventional IFDMA system for next‐generation communications.
Design, Synthesis, Biological Evaluation and Molecular Docking Study of New 1,3,4‐Thiadiazole‐Based Compounds as EGFR Inhibitors
Authors: Serag Marwa I. , Tawfik Samar S. , Eisa Hassan M. , Badr Sahar M. I. 
Published: December 2024

ABSTRACTFive series of new 1,3,4‐thiadiazole hybrids were designed and synthesized as promising EGFR inhibitors. Three human cancer cell lines were employed for testing each hybrid's in vitro antiproliferative efficacy; colon HCT‐116, liver HepG‐2 and breast MCF‐7 using MTT assay. Comparing compound 9a to the reference doxorubicin, 9a shown superior activity to that of Dox with respect to MCF‐7 (IC50 3.31 µM) while being secure for normal cells WI‐38 (IC50 = 43.99 µM). Further evaluation of the EGFR inhibitory activity of the most active candidates—4a, 6b, 8b, 9a, and 9 d—was performed. Of them, compounds 9a and 8b demonstrated the highest IC50 values, 0.08 and 0.15 µM, respectively, relative to the reference gefitinib (IC50 = 0.04 µM). Subsequent mechanistic analysis of compound 9a revealed a notable 14.24‐fold increase in overall apoptosis and a 28.92% cell cycle arrest at G2/M. Additionally, research on apoptosis demonstrated that it triggered the mitochondrial apoptotic pathway. In MCF‐7 cells, it also led to an increase in ROS buildup. For the most powerful EGFR inhibitors, 9a and 8b, a molecular docking research was conducted, and all of the findings agreed with the biological findings.
Detection of Oral Testosterone Undecanoate Administration in UGT2B17 del/del and del/ins Individuals. Part II: Urinary Endogenous Steroid Sulfate Markers
Authors: Coll Sergi , Shiomura Sho , Alechaga Élida , Bressan Claudia , Monfort Núria , Okano Masato , Ventura Rosa 
Published: December 2024

ABSTRACTThe detection of endogenous anabolic androgenic steroids misuse in Asian population using the Steroidal Module of the Athlete Biological Passport (ABP) is a challenge due to the high prevalence of UGT2B17 gene deletion polymorphism with low levels of testosterone (T) glucuronide. In this study, the capabilities of different approaches based on urine analysis for the detection of oral T undecanoate administration were evaluated in 13 Asian volunteers, including 11 subjects with del/del genotype and 2 subjects with del/ins genotype. In the first part of the work, the effect on the urinary steroid profile (SP) and on the isotope ratio mass spectrometry markers was evaluated. In this second part, the effect on endogenous sulfate markers was evaluated. Results showed that the oral T administration is detected for a much longer period of time with sulfate markers than with the conventional urinary SP markers. Androstanediol sulfate 1 (Diol‐S1)/dehydroandrosterone sulfate (DHA‐S) and epiandrosterone sulfate (epiA‐S)/DHA‐S ratios were the most diagnostic parameters for longitudinal monitoring, as reported for Caucasian volunteers in a previous work. For most subjects, sulfate markers allowed the detection of suspicious samples up to 144 h. Combinations of sulfate and glucuronide markers improved the sensitivity in comparison with the conventional SP markers, but yielded poorer results than the best sulfate ratios. Based on the results of this study and previous works, sulfate EAAS metabolites provide a consistent improvement in the detectability of T administration in both Caucasian and Asian populations. Their incorporation into the ABP should be considered.