bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collective health research assessment: Development of a tool to measure the impact of multi-stakeholder research initiatives
Authors: Kork Anna-Aurora , Antonini Carla , García-Torea Nicolás , Luque-Vílchez Mercedes , Costa Ericka , Senn Juliette , Larrinaga Carlos , Bertorello Deborah , Brichetto Giampaolo , Zaratin Paola , Andreaus Michele 
Published: November 2021

Abstract
Background

The need for measuring the impact of health research more collaboratively and from multi-dimensional perspectives has been acknowledged. As part of a Collective Research Impact Framework (CRIF), a scorecard was developed that will engage stakeholders in measuring the impacts of health research and innovation. The purpose of this study is to describe the developmental process of the MULTI-ACT Master Scorecard and how it can be used as a practical tool for assessing future responsible research and innovation actions collectively.
Methods

Based on an extensive review of the health research impact literature and multi-stakeholder initiatives, a total of 1,556 impact indicators were collected into a database. The Master Scorecard was then co-created by engaging key stakeholders and conducting semi-structured interviews with experts in the field.
Results

The MULTI-ACT Master Scorecard consists of five accountability dimensions: the excellence, efficacy, economic, social and patient-reported dimensions. The tool includes 126 potential indicators classified into 52 measurement aspects that are considered the most relevant topics applicable to multi-stakeholder research and innovation initiatives in assessing their impact based on their mission and stakeholders’ interests. The MULTI-ACT Master Scorecard allows the strategic management of multi-stakeholder research initiatives to demonstrate their research impact on people and society. The value of the tool is that it is comprehensive, customizable and easy to use.
Conclusions

The MULTI-ACT Master Scorecard is an example of how the views of society can be taken into account in assessing research impacts in a more sustainable and balanced way. The engagement of patients and other stakeholders is an integral part of the CRIF, facilitating collaborative decision-making in the design of policies and research agendas. In policy-making, the collective approach allows extending the evaluation perspective to the needs of society and toward responsible research and innovation. Multi-dimensionality fosters research and innovations to be more responsive to systemic challenges and developing more equitable and sustainable health services.
Pediatric Behcet's Disease Patient with Cardiac Valvular Lesions: case report and a review of the literature
Authors: Yao Xin , Wang Xin-Ning , Zhou Zhi-Xuan , Li Sheng-Nan , Lai Jianming 
Published: November 2021

Abstract
Background

To explore the clinical characteristics, treatment regimen, and prognosis of cardiac valvular involvement in pediatric Behcet's disease.
Methods

Retrospective analysis was conducted on the clinical data obtained from one pediatric patient suffering from Behcet's disease with cardiac valvular involvement. Present study also reviewed the literature related to cardiac involvement in pediatric Behcet's disease.
Results

The disease onset in the female patient was reported at the age of 3 years, with clinical symptoms, including apthous ulcers, fever, perianal ulcers, and erythema nodosum, accompanied by a significant increase in the inflammatory markers. Echocardiography indicated that aortic valve (AV) lesions, which were absent initially, developed later, gradually exacerbated. Initially, she was diagnosed as "infectious disease" and "systemic inflammatory response syndrome", and antibiotic therapy proved ineffective. After an accurate diagnosis of Behcet's disease, the patient was given glucocorticoids, immunosuppressants, and biologics, which resulted in the relief of the symptoms; however, cardiac valvular lesions continued to exacerbate. Subsequent treatment included medical treatment and surgical treatment, and the patient's condition was stable at follow-up.
Conclusions

Cardiac valvular lesions in pediatric Behcet's disease are rare with insidious onset, enhancing the propensity of misdiagnosis or missed diagnosis. Main manifestations include recurrent oral ulceration, skin lesions, and fever. Cardiac involvement may occur early, yet the symptoms are insidious, requiring comprehensive physical examination and close monitoring of echocardiography. Glucocorticoids combined with immunosuppressants are the primary therapy for cardiac involvement in Behcet's disease. When cardiac valvular damage and dysfunction are observed, treatment regimens can be jointly recommended by multidisciplinary consultation to conduct the surgical treatment on time.
3D Heat transfer Simulation of an injection mold: comparison between ANSYS Workbench and ANSYS Mechanical APDL
Authors: Silva Hugo Miguel , Fernandes Leandro , Rodrigues Hugo Luís , Noversa João Tiago , Pontes António José 
Published: November 2021

Abstract
Because of recent advancements in additive manufacturing, fabricating conformal cooling channels (CCCs) has become easier and more economical. In the injection molding process, CCCs provide higher cooling performance than standard (straight drilled) channels. The major reason for this is that CCCs may follow the courses of the molded geometry, whereas typical channels created using traditional machining processes cannot. Using CCCs can reduce thermal strains and warpage while also improving cycle time and achieving a more uniform temperature distribution. CCC, on the other hand, has a more complicated design procedure than traditional channels. Simulations using computer-aided engineering (CAE) are critical for achieving an effective and cost-effective design. This article compares two ANSYS modules for the purpose of validating results. It can be inferred that the two modules produce similar results for models with fine mesh. As a result, the ANSYS module to work on should be chosen depending on the job's goal as well as the CAD geometry's complexity.
Impact of the El Niño type and PDO on the Winter Sub-seasonal North American Zonal Temperature Dipole via the Variability of Positive PNA Events
Authors: Ge Yao , Luo Dehai 
Published: November 2021

Abstract
In recent years, the winter (from December to February, DJF) North American surface air temperature (SAT) anomaly in midlatitudes shows a “warm west/cold east” (WWCE) dipole pattern. To some extent, the winter WWCE dipole can be considered as being a result of the winter mean of sub-seasonal WWCE events. In this paper, the Pacific SST condition linked to the WWCE SAT dipole is investigated. It is found that while the sub-seasonal WWCE dipole is related to the positive Pacific North American (PNA+) pattern, the impact of the PNA+ on the WWCE dipole depends on the El Niño SST type and the phase of Pacific decadal Oscillation (PDO). For a central-Pacific (CP) type El Niño, the positive (negative) height anomaly center of PNA+ is located in the western (eastern) North America to result in an intensified WWCE dipole, though the positive PDO favors the WWCE dipole. In contrast, the WWCE dipole is suppressed under an Eastern-Pacific (EP) type El Niño because the PNA+ anticyclonic anomaly dominates the whole North America. Moreover, the physical cause of why the El Niño type influences PNA+ is further examined. It is found that the type of El Niño can significantly influence the location of PNA+ through changing North Pacific midlatitude westerly winds associated with the Pacific Hadley cell change. For the CP-type El Niño, the eastward migration of PNA+ is suppressed to favor its anticyclonic (cyclonic) anomaly appearing in the west (east) region of North American owing to reduced midlatitude westerly winds. But for the EP-type El Niño, midlatitude westerly wind is intensified to cause the appearance of PNA+ anticyclonic anomaly over the whole North America due to enhanced Hadley cell.
Heavy Metal Bioremediation by Novel Microbial Strains Proteus Mirabilis and Bordetella Avium
Authors: Ganorkar Rohini , Jadeja Niti B. , Shanware Arti 
Published: November 2021

Abstract
The entitled study focuses on exploring the microbial diversity and its applicability in the remediation of metal contaminated soil using microbes which is a reliable, and cost effective technique. Present investigation studied microbiota present in tungsten enriched soil of kuhi-Agargaon-Khobna region using culturable approach confirmed by ICP-MS and SEM-EDS analysis. Furthur applicability in Bioremediation and Azo Dye degradation was studied. XRF analyses of soil samples were performed followed by traditional microbiological analysis for isolation of tungsten tolerant bacteria’s. Tungsten accumulation was confirmed using ICP-MS and SEM-EDS techniques. Different metals and azo dye tolerance studies were conducted. Antibiotic susceptibility test revealed the antibiotic resistance profile of these microbes. XRF analyses of soil samples from these regions measured about 300 ppm tungsten/kg of soil at the Agargaon region and 200 ppm tungsten/kg of soil at the Khobna region. The traditional microbiological analysis resulted in two bacterial isolates which were identified for tolerance to tungsten named as Proteus mirabilis strain RS2K and Bordetella avium strain RS3K through 16S rDNA gene sequencing and phylogenetic analysis. These microbes were found to accumulate tungsten intracellularly as confirmed through ICP-MS and SEM-EDS analyses. In addition to (sodium) tungsten, the microbes were tolerant to tungstic acid, ammonium metaparatungstate, mercuric chloride, cobalt chloride and azo dyes .Microbes exhibited well-equipped cellular mechanisms for metal tolerance to survive in heavy metal-laden ecology. The novel strains obtained through a culturable approach in this study contain substantial potential in bioleaching of heavy metals and green mining.
Comparison of Region-of-Interest Delineation Methods for Diffusion Tensor Imaging in Patients with Cervical Spondylotic Radiculopathy
Authors: Wu Penghuan , Huang Chengyan , Shi Benchao , Jin Anmin 
Published: November 2021

Abstract
Background

Diffusion tensor imaging is a promising technique for determining the responsible lesion of cervical radiculopathy, but the selection and delineation of the region of interest (ROI) affects the results. To explore the impact of different ROI sketching methods on the repeatability and consistency of DTI measurement values in patients with cervical spondylotic radiculopathy (CSR).
Methods

This was a retrospective study that included CSR patients who underwent DTI imaging. The images were analyzed independently by two radiologists. Four delineation methods were used: free-hand method, maximum roundness, quadrilateral method, and multi-point averaging method. They re-examined the images 6 weeks later. To investigate the consistency between the two measurements and the reproducibility between two radiologists, the intra-class correlation coefficient (ICC) was used.
Results

A total of 42 CSR patients were enrolled in this study. The distribution of compressed nerve roots was five C4, eight C5, sixteen C6, eleven C7, and two C8. No difference was found among the four methods in fractional anisotropy (FA) or apparent diffusion coefficient (ADC), irrespective of radiologists. (all P>0.05). Similar results were observed between the first and second measurements (all P>0.05), but some significant differences were observed for radiologist 2 for the four-small rounds method (P=0.033). Between the two measurements and the two radiologists, the free-hand and single largest circle methods were the two methods with the highest ICC (all ICC >0.90).
Conclusion

For the delineation of DTI ROI in patients with CSR, the free-hand and single largest circle methods were the most consistent methods.
Genetic predisposition to papillary thyroid carcinoma is mediated by a long non-coding RNA TINCR enhancer polymorphism
Authors: Wang Qiang , Huang Hong , Chen Peng , Xiao Xiao , Luo Xiaolei , Wang Yanyun , Gao Linbo , Zhang Lin 
Published: November 2021

Abstract
Single nucleotide polymorphisms (SNPs) in the enhancer region have been demonstrated to confer to altered enhancer activities, aberrant gene expression, and cancer susceptibility. In this study, we aimed to examine the association between an SNP, rs8101923, within terminal differentiation-induced non-coding RNA (TINCR) and the risk of papillary thyroid carcinoma (PTC). Blood samples from 559 patients with PTC and 445 healthy individuals were collected. The rs8101923 was genotyped by using polymerase chain reaction-restriction fragment length polymorphism assay. The impact of the rs8101923 on TINCR expression and enhancer activity was evaluated by quantitative real-time PCR and dual-luciferase reporter assay. The binding of AP-2α to TINCR enhancer was determined by chromatin immunoprecipitation. The rs8101923 G allele was significantly associated with a higher risk of PTC (adjusted OR = 1.37; 95% CI: 1.15–1.64). Mechanistically, the rs8101923 was related to increased transcriptional levels and enhancer activities (P < 0.05). Transcription factor AP-2α binds to the enhancer region of TINCR containing the rs8101923 locus, and promotes cell proliferation in PTC. These findings suggest the rs8101923 as a risk factor in the pathogenesis of PTC, which provides evidence for explaining the mechanism of the rs8101923 risk allele predisposing to PTC.
TMEM88 is a Prognostic Biomarker and Correlates With Immune Infiltrates in Hepatocellular Carcinoma
Authors: Liman Andrew , Gu Yang , Liu Pengpeng , Liu Quanyan 
Published: November 2021

Abstract
BackgroundTransmembrane protein 88 (TMEM88) has emerged as a newly discovered cancer-related protein that acts as a cancer-promoting or cancer-inhibiting regulator in multiple tumor types. However, the exact role of TMEM88 in liver cancer is undetermined. The current study was designed to determine the expression of TMEM88 in liver cancer. ResultsTMEM88 expression was significantly lower in several human cancers, but higher in liver and bile cancer, than in corresponding normal tissues. TMEM88 expression in HCC tissues correlated with prognosis. Low TMEM88 expression associated with poorer overall survival, disease-specific survival, progression-free survival, and relapse-free survival in multiple cohorts of HCC patients, particularly at late disease stages (grade 2 and 3). TMEM88 showed strong correlation with tumor-infiltrating B cells, CD4+ and CD8+ T cells, macrophages, neutrophils, and dendritic cells. ConclusionThese findings demonstrate that TMEM88 is a potential prognostic biomarker that determines cancer progression and correlated with tumor immune cells infiltration in HCC.
Squamous cell carcinoma of the kidney in an End Stage Renal disease patient in a tertiary health care center; a case report and review of literature, Assiut university hospital experience 2021,
Authors: abdelkader abdelrahman mohamed , Zarzour mohamed 
Published: November 2021

Abstract
The literature mentioned few case that are squamous cell carcinoma of the renal pelvis since 1955. Renal cell carcinoma with all its variants represent more than ninety percent, the remaining ten percent is divided on urothelial tumors, sarcomas and metastasis from other organs. Squamous cell carcinoma of the urothelium is not common, but in Egypt it was very frequently seen in the bladder, multiple cause are proposed such as the chronic irritation caused by Schistosomiasis infection .The general role of this type is that it is resistant to both chemo and radiotherapy with fair outcome to surgery if early intervention was done. This article will discuss a case that developed squamous cell carcinoma in the renal bed after nephrectomy, which was managed with excellent outcome in assiut university hospital
Quantification of Industrial Wastewater Discharge From The Major Cities in Sichuan Province (China) From 2003 To 2018
Authors: Yang Zhen’an , Zhang Yawen , guo Hui , Ma Zhaoxu 
Published: November 2021

Abstract
Wastewater discharge is produced as a side effect of socio-economic activities and exerts severe pressure on the environment, its characteristics depend on the rate of urbanization and industrialization. We used spatial autocorrelation, environmental Kuznets curve (EKC), and logarithmic mean Divisia index (LMDI) model to study the spatial characteristics and driving factors of industrial wastewater discharge in Sichuan province (2003–2018). We showed that the amount of industrial wastewater discharge in Sichuan province for the period was reduced from 116580 to 42064.96 million tons as observed from the Moran index ranging from -0.31 to 0.30. We identified five types of the EKC (monotonically decreasing, N, inverted N, U, and inverted U shape) in 18 major cities of Sichuan province. The technical effect (from -0.28 to -16.37) can reduce the discharge of industrial wastewater, while structure effect (0.05–3.83), economy effect (0.19–7.79) and population effect (from -0.08 to 0.46) can promote the industrial wastewater discharge. Our findings suggest that industrial wastewater discharge was reduced and showed a scattered distribution characteristic in Sichuan Province from 2003 to 2018. It is necessary to strengthen technical management measures to reduce industrial wastewater discharge in Sichuan province.
Steady-State Visual Evoked Potentials in Children With Neurofibromatosis Type 1: Associations With Behavioural Rating Scales And Impact of Psychostimulant Medication
Authors: Lalancette Eve , Charlebois-Poirier Audrey-Rose , Agbogba Kristian , Knoth Inga Sophia , Jones Emily J.H. , Mason Luke , Perreault Sébastien , Lippé Sarah 
Published: November 2021

Abstract
Background: Neurofibromatosis type 1 (NF1) is a genetic disorder often associated with cognitive dysfunctions, including a high occurrence of deficits in visuoperceptual skills. The neural underpinnings of these visuoperceptual deficits are not fully understood. We used steady-state visual evoked potentials (SSVEPs) to investigate possible alterations in the synchronization of neural activity in the occipital cortex of children with NF1. Methods: SSVEPs were measured using electroencephalography and compared between children with NF1 (n = 28) and neurotypical controls (n=28) aged between 4 and 13 years old. SSVEPs were recorded during visual stimulation with coloured icons flickering at three different frequencies (6Hz, 10Hz and 15 Hz) and analyzed in terms of signal-to-noise ratios. A mixed design ANCOVA was performed to compare SSVEP responses between groups at the three stimulation frequencies. Pearson’s correlations with levels of intellectual functioning as well as with symptoms of ADHD, ASD and emotional/behavioural problems were performed. The impact of psychostimulant medication on the SSVEP responses was analyzed in a subset of the NF1 group (n=8) with paired t-tests.Results: We observed reduced signal-to-noise ratios of the SSVEP responses in children with NF1. The SSVEP responses were negatively correlated with symptoms of inattention and with symptoms of emotional/behavioural problems in the NF1 group. The SSVEP response generated by the lowest stimulation frequency (i.e., 6Hz) was rescued with the intake of psychostimulant medication. Conclusions: Impaired processing of rhythmic visual stimulation was evidenced in children with NF1 through measures of SSVEP responses. Those responses seem to be more reduced in children with NF1 who exhibit more symptoms of inattention and emotional/behavioral problems in their daily life. SSVEPs are potentially sensitive electrophysiological markers that could be included in future studies investigating the impact of medication on brain activity and cognitive functioning in children with NF1.
Experience for Glaucoma Patients During the COVID-19 Outbreak
Authors: qian ye , Ye Qian , Chen Xiao , Song Yanping , Zhang Wen-qiang 
Published: November 2021

Abstract
Purpose: To reviewed our measures and other experiences associated with the treatment of glaucoma patients during the 2019 novel coronavirus disease (COVID-19) outbreak . Methods: Measures consistent with the clinical situation and the type of glaucoma were implemented in each case. Results: Consultation for treatment was provided through a WeChat glaucoma patient group. In our survey, 58.5%patients indicated an increase in negative emotions during the outbreak, and psychological counseling was provided frequently. Difficulties in purchasing eye drops were reported by 79.2% of glaucoma patients, so an online medicine supply system was set up and eyedrops from the pharmacy or hospital pharmacy were mailed to the patients. Phacoemulsification with goniosynechialysis was performed in7acute primary angle-closure glaucomapatients (11eyes) who experienced sustained high IOP(onset time, 12-65d). The IOP decreased significantly after the operation(t=7.895，P<0.01) without showing serious complications or infections. In addition, lectureson glaucoma prevention were promoted online. Conclusion: Effective measures can relieve thepsychological pressure and intraocular symptoms in glaucoma patientsin epidemic outbreak areas.
Improving Mechanical Property and Microstucture Evolution of 7075 Aluminum Panel Formed by Unequal Alternate Double-sided Laser Shock Forming
Authors: Yang Yuqi , Qiao Hongchao , Lu Ying , Zhao Jibin , sun boyu , he jiaqi 
Published: November 2021

Abstract
With thrust weight ratio increasing, integral panel is an important component to reduce the aircraft weight, and it is a great challenges to ensure the forming accuracy and mechanical property in the lager-scale panel. Laser shock forming has a great development prospect in achieving integral panel forming and improving its mechanical properties. This work investigated unequal alternate double-sided laser shock forming, which can make 7075 aluminum panel form and induce harden layer in both panel sides. The improvement in mechanical properties and microstucture evolution of 7074 aluminum panel were analyzed after unequal alternate double-sided laser shock forming. The residual stress and microhardness in surface and subsurface were verified to be enhanced by the laser shock wave. The results of XRD and EBSD provided an evidence of grain refinement. The strengthening mechanism of unequal alternate double-sided laser shock forming was analyzed in this work. The grains are distorted and refined during high strain rate plastic deformation due to dislocation slip and accumulation. The mechanical properties were enhanced by unequal alternate double-sided laser shock forming for harden layers in both panel sides. The harden layers and grain refinement has a great significance in inhibiting the crack generation and growth.