bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological variation of cardiac myosin-binding protein C in healthy individuals
Authors: Alaour Bashir , Omland Torbjørn , Torsvik Janniche , Kaier Thomas E. , Sylte Marit S. , Strand Heidi , Quraishi Jasmine , McGrath Sam , Williams Luke , Meex Steven , Redwood Simon , Marber Michael , Aakre Kristin M. 
Published: June 2021

Abstract

Objectives
Cardiac myosin-binding protein C (cMyC) is a novel biomarker of myocardial injury, with a promising role in the triage and risk stratification of patients presenting with acute cardiac disease. In this study, we assess the weekly biological variation of cMyC, to examine its potential in monitoring chronic myocardial injury, and to suggest analytical quality specification for routine use of the test in clinical practice.

Methods
Thirty healthy volunteers were included. Non-fasting samples were obtained once a week for ten consecutive weeks. Samples were tested in duplicate on the Erenna® platform by EMD Millipore Corporation. Outlying measurements and subjects were identified and excluded systematically, and homogeneity of analytical and within-subject variances was achieved before calculating the biological variability (CVI and CVG), reference change values (RCV) and index of individuality (II).

Results
Mean age was 38 (range, 21–64) years, and 16 participants were women (53%). The biological variation, RCV and II with 95% confidence interval (CI) were: CVA (%) 19.5 (17.8–21.6), CVI (%) 17.8 (14.8–21.0), CVG (%) 66.9 (50.4–109.9), RCV (%) 106.7 (96.6–120.1)/−51.6 (−54.6 to −49.1) and II 0.42 (0.29–0.56). There was a trend for women to have lower CVG. The calculated RCVs were comparable between genders.

Conclusions
cMyC exhibits acceptable RCV and low II suggesting that it could be suitable for disease monitoring, risk stratification and prognostication if measured serially. Analytical quality specifications based on biological variation are similar to those for cardiac troponin and should be achievable at clinically relevant concentrations.
Entrepreneurship and Firm Strategy: Integrating Resources, Capabilities, and Judgment through an Austrian Framework
Authors: Möller Ulrich , McCaffrey Matthew 
Published: June 2021

AbstractDespite numerous calls for integrating entrepreneurship research and firm theory, there has been relatively little work done in this direction. Likewise, despite many discussions, controversy continues to surround core theoretical frameworks in strategic management such as the resource-based view and capabilities theory. This paper uses insights from early research in Austrian economics to resolve both issues. We focus on Viktor Mataja, whose work provides an original, integrated framework for understanding the relationship between entrepreneurs and firms using the judgment-based approach to entrepreneurship, strategic use of resources in the firm, and dynamic capabilities. We show how this view answers various criticisms that have been raised against the resource- and capabilities-based views. This lays a foundation for a more thoroughgoing integration of research in entrepreneurship and strategic management.
The state of adolescent medicine as a specific field: an international exploratory survey
Authors: Fonseca Helena , Michaud Pierre-André 
Published: June 2021

Abstract

Objectives
The emergence of adolescent medicine (AM) as a specific area of training and health care delivery is progressing at various pace around the world. The objective of this exploratory survey was to inquire about the existence of official bodies and institutions offering recognition of the discipline as a specific field and on the status of related training initiatives.

Methods
A questionnaire was spread among a convenience sample of 21 colleagues involved in adolescent health care around the world, and answers were collected and analysed manually.

Results
All 21 colleagues from the North and South American, African, Asian and European regions have responded. Only seven countries report the existence of adolescent inpatient wards in some hospitals, while 16 have specialized outpatient clinics; in only eight countries is formal mandatory training in AM required for paediatricians; in seven others, such a stay is available but optional. Six countries have implemented a systematic assessment tackling AM in the certification process of paediatricians and just four recognize AM as a sub-specialty. Only two countries mention compulsory training in AM for family doctors. Fourteen countries report on the existence of an AM association.

Conclusions
Despite an encouraging number of initiatives testifying the growing place of AM in the practice of medicine, our data bring a worrisome portray of the status of AM in the involved countries and call for the development of appropriate health care and training centres.
Effect of luteolin on the gene level expression of apoptosis-associated speck-like protein containing a caspase recruitment domain of NLRP3 inflammasome and NF-κB in rats subjected to experimental pancreatitis – influence of HSP70
Authors: Rajapriya Sadanandan , Geetha Arumugam 
Published: June 2021

Abstract

Objectives
Nod-like receptor pyrin domain containing 3 (NLRP3) is one of the well characterized inflammasome that controls the maturation of pro-inflammatory cytokines and thereby the inflammation in pancreas which could be a promising target for anti-inflammatory drugs. The present study is aimed to explore whether luteolin can target the NLRP3 inflammasome and modulate its activity through the signaling protein, HSP70 in the ethanol-cerulein model of experimental pancreatitis.

Methods
Male albino Wistar rats were divided into four groups. Groups 1 and 2 rats received normal diet. Groups 3 and 4 rats received isocalorically adjusted diet containing ethanol for 5 weeks and cerulein (20 μg/kg body weight i.p., thrice weekly for the last 3 weeks of the experimental period). Additionally, group 2 and 4 rats received 2 mg/kg body weight of luteolin orally from third week.

Results
Luteolin co-administration decreased the serum levels of HSP70, oxidative stress markers, myeloperoxidase, GSH/GSSG and GST with concomitant downregulation in the mRNA expression of HSP70, caspase-1, ASC-NLRP3 and NF-κB. Spearman’s rank correlation test showed that serum HSP70 has positive correlation with the expression of ASC-NLRP3, caspase-1, NF-κB and 4-hydroxynonenal and negative correlation with GSH:GSSG ratio.

Conclusions
The modulating effect of luteolin on the expression of HSP70, NF-κB and thereby on ASC-NLRP3 complex may be claimed for its pancreato-protective activity.
A non-inferiority randomized controlled clinical trial comparing Unani formulations and PUVAsol in non-segmental vitiligo
Authors: Husain Nazim , Uddin Qamar , Kazmi Munawwar Husain , Khalid Mohd 
Published: June 2021

AbstractObjectivesGreco-Arab medicine is an ancient system of medicine with greater treasure on therapeutics of vitiligo. The trial Unani formulations have not been scientifically explored for their safety and efficacy, but have been repeatedly prescribed by the great Unani physicians in the management ofBaraṣ(vitiligo). Hence, these interventions were selected for the trial.MethodsIn this randomized, controlled, open-label clinical trial, 82 participants with non-segmental vitiligo aged 18–40 years were block randomized to either receive Unani interventions or control for 16 weeks. Out of 82 participants, 42 were randomized to the Unani group and 40 were randomized to the control group. The primary outcome measure was change in vitiligo area scoring index (VASI), which was assessed on weeks 4, 8, 12 and 16. The secondary outcome measures included the patient’s global assessment on VAS and investigator’s global assessment based on photographic evaluation at baseline and after the treatment. Safety parameters included hemogram, LFTs, RFTs, CXR, ECG, urine, and stool examinations, which were evaluated at baseline and after the treatment.ResultsThe per-protocol analysis was done on 30 participants in each group and the response in Unani group was not inferior to those receiving control group. The mean ± SD of vitiligo area scoring index (VASI) decreased from 4.09 ± 2.87 and 5.50 ± 5.73 at baseline to 3.13 ± 2.20 and 4.29 ± 4.95 at the end of the trial in both the Unani and control groups respectively.ConclusionsThe study inferred that both the interventions are equally effective and well-tolerated in patients with non-segmental vitiligo.
Metabolic syndrome and cardiorespiratory fitness in children and adolescents: the role of obesity as a mediator
Authors: González-Gálvez Noelia , Ribeiro Jose , Mota Jorge 
Published: June 2021

Abstract

Objectives
To analyse the prevalence and association between metabolic syndrome (MetS), clustered cardiometabolic risk (CCMR), obesity (body mass index [BMI], fat mass [FM] and waist circumference [WC]), and cardiorespiratory fitness (CRF); and to assess whether obesity (BMI, FM, and WC) acts as a mediator between CRF and MetS or CCMR.

Methods
This cross-sectional study included a subsample of the AFINA-te Study (n = 209; 11.51 ± 0.72 years old). BMI, FM, and WC were assessed. The Course-Navette test was used to assess CRF. MetS was calculated following the International Diabetes Federation (IDF) definitions, and assessed using WC, triglycerides (TGs), high density lipoprotein (HD), fasting glucose (FG), and systolic and diastolic blood pressures (SBP/DBP). CCMR was calculated based on the sex and age-specific z score.

Results
The prevalence of overweightness, obesity, MetS, and CCMR were 17.22, 1.44, 5.74, and 18.36%, respectively. After including BMI, FM, or WC into the model, the association between CRF and MetS was no longer significant, and the association between CRF and CCMR was only significant when it was mediated by BMI (β = −0.006; p = 0.026). The rest of the analysis of the mediation did not show a direct effect, although a significant indirect effect with a significant value for the Sobel test was observed (all p < 0.001).

Conclusions
BMI, FM, and WC act as full mediators in the association between CRF and MetS; FM and WC act as full mediators in the association between CRF and CCMR; and BMI acts as a partial mediator. The use of FM or WC as obesity variables is recommended.
Can Good Intentions Bring Negative Consequences? The Perceived Positive and the Side Effects of the Law on Alcohol Control
Authors: Morkunas Mangirdas 
Published: June 2021

Abstract
The present study addresses the perceived effects of the implementation of the Law on Alcohol Control passed by the Lithuanian Parliament. The current study provides initial scientific insights into the rationale and the outcomes of that piece of legislation. The results of the research were analyzed from both economic and social perspectives. The study revealed that although the implementation of the Law on Alcohol Control did induce significant positive changes in society’s perception towards consumption of alcohol, it also provoked some side effects in economic and social perspectives.
Knee alterations in rheumatoid arthritis: Comparison of US and MRI
Authors: Xiao Lu , Huang Yanyan , Zhan Feng 
Published: June 2021

Abstract

Objective
This study was designed to compare the diagnostic efficacy of ultrasonography (US) and magnetic resonance imaging (MRI) in detecting changes in the knee of patients with rheumatoid arthritis (RA) and discover the possible association between the serological index and bone erosion detected by US.

Patients and methods
In this retrospective study, the US images and MRI findings of the knee in patients with RA from December 2017 to January 2020 were evaluated. Diagnostic outcomes were compared. The rheumatoid factor, C-reactive protein, erythrocyte sedimentation rate, and anti-cyclic citrullinated peptide antibody (ACPA) levels of the patients were recorded. The relation between laboratory index and US findings was analyzed by multivariable logistic regression.

Results
US showed remarkable accuracy, sensitivity, and specificity in diagnosing synovitis, bone erosion, and soft tissue swelling. In terms of reliability, the agreement between US and MRI was moderate to almost perfect. Meanwhile, a positive association between ACPA level and bone erosion was observed in patients with RA.

Conclusions
US may have a role as the initial imaging modality in patients with RA. Patients with higher ACPA levels may need more active treatment because they are more likely to have bone erosion detected by US.
The crystal structre of 3-(1-ethenyl-1H-imidazol-3-ium-3-yl)propane-1-sulfonate, C8H12N2O3S
Authors: Zhu Yanfang , Xu Guiyang , Song Wenqi , Miao Zongcheng 
Published: June 2021

Abstract
C8H12N2O3S, monolinic, P21/n (no. 14), a = 6.0324(5) Å, b = 7.1692(6) Å, c = 21.6655(17) Å, β = 97.022(3)°, V = 929.95(13) Å3, Z = 4, R

gt
(F) = 0.0409, wR

ref
(F
2) = 0.1201, T = 193 K.
An implicit scheme for simulation of free surface non-Newtonian fluid flows on dynamically adapted grids
Authors: Nikitin Kirill , Vassilevski Yuri , Yanbarisov Ruslan 
Published: June 2021

Abstract
This work presents a new approach to modelling of free surface non-Newtonian (viscoplastic or viscoelastic) fluid flows on dynamically adapted octree grids. The numerical model is based on the implicit formulation and the staggered location of governing variables. We verify our model by comparing simulations with experimental and numerical results known from the literature.
VI. Paolo Comitoli SJ on Contracts
Authors: Alexandrowicz Piotr 
Published: June 2021

Summary
Contract law in the early modern period has always been the subject of intensive research. The present article is intended as a contribution to this. It presents the contract doctrine of an Italian Jesuit, Paolo Comitoli. He was a moral theologian and author of the “Doctrina de contractu”. The paper begins with a biographical introduction and an overview of Comitoli’s writings. News about Comitoli’s life, however, is sparse and widely dispersed. The following section focuses on Comitoli’s concept of and his definition of contract. A brief explanation of Comitoli’s concept of contract attributes follows. Comitoli saw in these attributes the identity-forming characteristics of all contracts and used these elements to place the traditional problems of contract theory in a new framework.
IT-Sicherheit in der vernetzten Produktion
Authors: Kiesel Raphael , Kies Alexander , Kreppein Alexander , Schmitt Robert H. 
Published: June 2021

Abstract
Die Potenziale der Industrie 4.0 für produzierende Unternehmen sind enorm, drohen aufgrund unzureichender IT-Sicherheitsmaßnahmen jedoch ungenutzt zu bleiben. Am Fraunhofer IPT wurde daher der „Production Security Readiness Check“ (PSRC) entwickelt, der Unternehmen eine Selbsteinschätzung bzgl. des IT-Sicherheit-Reifegrads ermöglicht. Der PSRC wird in diesem Beitrag vorgestellt und darüber hinaus das Ergebnis einer Studie von 28 Unternehmen, die den Check durchgeführt haben, beleuchtet.
MES-System mit Fertigungskommunikation
Authors: Winter Florian 
Published: June 2021

Abstract
In einem vom Bundesministerium für Wirtschaft und Energie (BMWi) geförderten Forschungsprojekt entwickeln die ATS Elektronik GmbH, das Institut für Fertigungstechnik und Werkzeugmaschinen (IFW) der Leibniz-Universität Hannover und die FAUSER AG Lokalisierungs- und Kommunikationsfunktionen für das Manufacturing Execution System der Zukunft. Das Projekt soll zum Jahresende 2021 abgeschlossen sein.
Algorithmische Produktion: Framework für den Shopfloor der Zukunft
Authors: Gerber Stefan , Ahmad Daban 
Published: June 2021

Abstract
In diesem Fachaufsatz wird das Prinzip der algorithmischen Produktion als eine Lösung vorgestellt, um den Anforderungen moderner Produktionseinrichtungen gerecht zu werden und die Fertigung hochgradig individualisierbarer Produkte zu realisieren. Zur Implementierung der algorithmischen Produktion werden drei verschiedene Architekturszenarien vorgeschlagen. Die Implementierung des Ansatzes wird abschließend an einem Referenzbeispiel für die Elektromotorenherstellung aufgezeigt.
Expertengestützte Data-Science-Projekte für die Produktion
Authors: Morlock Friedrich , Boßlau Mario 
Published: June 2021

Abstract
Technische Entwicklungen wie Datensammler und Analysewerkzeuge ermöglichen neue Optimierungspotenziale in der Produktion. Ein gutes Beispiel dafür ist das Themenfeld Data Science. Big-Data-Analysen oder Data-Science-Projekte können aus großen Datenmengen Hinweise und Optimierungspotenziale in der Produktion aufdecken. Für die Datenanalyse hat sich in Wissenschaft und Praxis der CRISP-DM-Ansatz durchgesetzt. Dieses Vorgehensmodell bietet eine gute Unterstützung für Data-Science-Projekte mit nützlichen Methoden und Werkzeugen zur Datenanalyse. In der Praxis ist jedoch oft zu beobachten, dass diese Projekte häufig von Datenexperten durchgeführt werden und die Verknüpfung von langjährigem Prozesswissen fehlt. In diesem Beitrag wird als Lösung eine Kombination von Prozessoptimierungsmethoden aus dem Lean-Management- und Six-Sigma-Werkzeugkasten sowie Projektmanagement-Methoden für jede Phase des CRISP-DM-Ansatzes vorgestellt.
Der Einkauf zwischen Produktion und Beschaffungsmarkt
Authors: Koch Volker 
Published: June 2021

Abstract
Personen im Einkauf, welche die Einkaufsaufgabe in Organisationen wahrnehmen, gehören sowohl in öffentlichen als auch privaten Unternehmen zu den wichtigsten Funktionen. Der Wertschöpfungsanteil wird in hohem Maße in Einkaufabteilungen generiert. Dieser Beitrag soll aufzeigen, welche Möglichkeiten der Motivationserfassung für die handelnden Personen im Einkauf wahrgenommen werden können. Weiters werden in diesem Beitrag ein Konzept zur Messung der Motivation angewendet und die im Einkauf handelnden Personen analysiert.
Effect of Active Recovery Protocols on the Management of Symptoms Related to Exercise-Induced Muscle Damage: A Systematic Review
Authors: Fares Rony , Vicente-Rodríguez Germán , Olmedillas Hugo 
Published: June 2021

ABSTRACT
Active recovery offers an efficient method to relieve delayed onset muscle soreness and recover from exercise-induced muscle damage (EIMD). The main aim of this systematic review is to identify and compare different active recovery protocols after EIMD. Six databases were searched, and 17 eligible studies were selected. Results showed alleviation of soreness, prevention of muscle strength loss, improvement in flexibility, and a decrease in inflammation after one or more recovery protocols such as isolated muscle contractions, aqua exercise, yoga, and combined jogging and running. A better strategy should focus on prevention of symptoms after EIMD through a precise training periodization and adjustment of load used in exercises.
Use of Physical Fitness Assessments in Tactical Populations
Authors: Orr Robin M. , Lockie Robert , Milligan Gemma , Lim Cheryl , Dawes Jay 
Published: June 2021

ABSTRACT
Physical fitness assessments for tactical occupations (e.g., military, law enforcement, and emergency services) can include predictive tests of anaerobic power, cardiovascular fitness, muscular endurance, muscular power, strength, agility, and/or simulated occupational tasks. Not only can these tests be used to assess the ability of someone to undertake the job role but they can be used to determine injury risk, training failure, and/or general health. This review discusses different uses for physical fitness assessments and considerations for their use in tactical populations.
Systemic pseudohypoaldosteronism-1 with episodic dyslipidemia in a Sudanese child
Authors: Abdalla Asmahan , Alhassan Mohammed Abdulrahman , Tawfeeg Reem , Sanad Ayman , Tawamie Hasan , Abdullah Mohamed 
Published: June 2021

Summary
Systemic pseudohypoaldosteronism type 1 (PHA1) is a rare genetic syndrome of tissue unresponsiveness to aldosterone caused by mutations affecting the epithelial Na channel (ENaC). The classical presentation is life-threatening neonatal/infantile salt-losing crises that mimic congenital adrenal hyperplasia (CAH). Consistently, extra-renal manifestations, including respiratory symptoms that resemble cystic fibrosis, are well reported. Clinical diagnosis is made by the presence of hyponatremia, hyperkalemia, metabolic acidosis, respiratory symptoms, evidence of high renal and extra-renal salt loss in addition to high plasma renin and aldosterone levels. We herein report a novel manifestation of PHA1: episodic dyslipidemia in a 7-month-old Sudanese boy that occurred during the salt-losing crises. Whole exome sequencing of the patient revealed one homozygous missense variant c.1636G>A p.(Asp546Asn) in the SCNN1B gene, confirming our clinical and laboratory findings that were compatible with PHA1. This report aims to highlight the possible explanation of dyslipidemia in PHA1 and its expected consequences in the long term.

Learning points

A child presenting with features that mimic salt-losing congenital adrenal hyperplasia (CAH) crises that do not respond to glucocorticoid and mineralocorticoid therapy should alert the pediatricians to the possibility of end-organ resistance to aldosterone.

Pseudohypoaldosteronism type 1 (PHA1) can be diagnosed even in the absence of advanced laboratory investigations.

To our knowledge, this is the first case of systemic PHA1 to have a documented episodic dyslipidemia (primarily as marked hypertriglyceridemia).
A flexible and concerned European Union – A new proposal
Authors: Dallago Bruno , Rosefielde Steven 
Published: June 2021

AbstractThe paper proposes the construction of a multi-speed, multi-track and multi-level European Union framework as a way to increase the flexibility of the integration process and facilitate inter-country conflict resolution. The paper shows that this malleable framework is superior, even for sensitive macroeconomic spillover issues like monetary union and immigration.
Competitiveness in the Serbian growth strategy
Authors: Ćorović Enes , Gligorijević Živorad 
Published: June 2021

AbstractThe paper focuses on the effects of the reformed growth strategy on the competitiveness of the Serbian manufacturing industry during the period of 2007–2016. The paper applies the analytical tools devised by the International Trade Centre, as well as Balassa's RCA Index and some other methodologies. All indicators point to similar conclusion: the reformed growth model would significantly contribute to the improvement of Serbian competitiveness. The starting point of Serbia is also clear: small gross investment volume and a low average growth rate.