bluuebunny/crossref_metadata_2025_split huggingface dataset:
A large-scale retrospective study of opioid poisoning in New York State with implications for targeted interventions
Authors: Chen Xin , Hou Wei , Rashidian Sina , Wang Yu , Zhao Xia , Leibowitz George Stuart , Rosenthal Richard N. , Saltz Mary , Saltz Joel H. , Schoenfeld Elinor Randi , Wang Fusheng 
Published: March 2021

AbstractOpioid overdose related deaths have increased dramatically in recent years. Combating the opioid epidemic requires better understanding of the epidemiology of opioid poisoning (OP). To discover trends and patterns of opioid poisoning and the demographic and regional disparities, we analyzed large scale patient visits data in New York State (NYS). Demographic, spatial, temporal and correlation analyses were performed for all OP patients extracted from the claims data in the New York Statewide Planning and Research Cooperative System (SPARCS) from 2010 to 2016, along with Decennial US Census and American Community Survey zip code level data. 58,481 patients with at least one OP diagnosis and a valid NYS zip code address were included. Main outcome and measures include OP patient counts and rates per 100,000 population, patient level factors (gender, age, race and ethnicity, residential zip code), and zip code level social demographic factors. The results showed that the OP rate increased by 364.6%, and by 741.5% for the age group > 65 years. There were wide disparities among groups by race and ethnicity on rates and age distributions of OP. Heroin and non-heroin based OP rates demonstrated distinct temporal trends as well as major geospatial variation. The findings highlighted strong demographic disparity of OP patients, evolving patterns and substantial geospatial variation.
Elucidating the genetics of grain yield and stress-resilience in bread wheat using a large-scale genome-wide association mapping study with 55,568 lines
Authors: Juliana Philomin , Singh Ravi Prakash , Poland Jesse , Shrestha Sandesh , Huerta-Espino Julio , Govindan Velu , Mondal Suchismita , Crespo-Herrera Leonardo Abdiel , Kumar Uttam , Joshi Arun Kumar , Payne Thomas , Bhati Pradeep Kumar , Tomar Vipin , Consolacion Franjel , Campos Serna Jaime Amador 
Published: March 2021

AbstractWheat grain yield (GY) improvement using genomic tools is important for achieving yield breakthroughs. To dissect the genetic architecture of wheat GY potential and stress-resilience, we have designed this large-scale genome-wide association study using 100 datasets, comprising 105,000 GY observations from 55,568 wheat lines evaluated between 2003 and 2019 by the International Maize and Wheat Improvement Center and national partners. We report 801 GY-associated genotyping-by-sequencing markers significant in more than one dataset and the highest number of them were on chromosomes 2A, 6B, 6A, 5B, 1B and 7B. We then used the linkage disequilibrium (LD) between the consistently significant markers to designate 214 GY-associated LD-blocks and observed that 84.5% of the 58 GY-associated LD-blocks in severe-drought, 100% of the 48 GY-associated LD-blocks in early-heat and 85.9% of the 71 GY-associated LD-blocks in late-heat, overlapped with the GY-associated LD-blocks in the irrigated-bed planting environment, substantiating that simultaneous improvement for GY potential and stress-resilience is feasible. Furthermore, we generated the GY-associated marker profiles and analyzed the GY favorable allele frequencies for a large panel of 73,142 wheat lines, resulting in 44.5 million datapoints. Overall, the extensive resources presented in this study provide great opportunities to accelerate breeding for high-yielding and stress-resilient wheat varieties.
Metabolomics shows the Australian dingo has a unique plasma profile
Authors: Yadav Sonu , Pickford Russell , Zammit Robert A. , Ballard J. William O. 
Published: March 2021

AbstractDingoes occupy a wide range of the Australian mainland and play a crucial role as an apex predator with a generalist omnivorous feeding behaviour. Dingoes are ecologically, phenotypically and behaviourally distinct from modern breed dogs and have not undergone artificial selection since their arrival in Australia. In contrast, humans have selected breed dogs for novel and desirable traits. First, we examine whether the distinct evolutionary histories of dingoes and domestic dogs has lead to differences in plasma metabolomes. We study metabolite composition differences between dingoes (n = 15) and two domestic dog breeds (Basenji n = 9 and German Shepherd Dog (GSD) n = 10). Liquid chromatography mass spectrometry, type II and type III ANOVA with post-hoc tests and adjustments for multiple comparisons were used for data evaluation. After accounting for within group variation, 62 significant metabolite differences were detected between dingoes and domestic dogs, with the majority of differences in protein (n = 14) and lipid metabolites (n = 12), mostly lower in dingoes. Most differences were observed between dingoes and domestic dogs and fewest between the domestic dog breeds. Next, we collect a second set of data to investigate variation between pure dingoes (n = 10) and dingo-dog hybrids (n = 10) as hybridisation is common in regional Australia. We detected no significant metabolite differences between dingoes and dingo-dog hybrids after Bonferroni correction. However, power analysis showed that increasing the sample size to 15 could result in differences in uridine 5′-diphosphogalactose (UDPgal) levels related to galactose metabolism. We suggest this may be linked to an increase in Amylase 2B copy number in hybrids. Our study illustrates that the dingo metabolome is significantly different from domestic dog breeds and hybridisation is likely to influence carbohydrate metabolism.
IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development
Authors: Hasegawa Hideaki , Mizoguchi Izuru , Orii Naoko , Inoue Shinya , Katahira Yasuhiro , Yoneto Toshihiko , Xu Mingli , Miyazaki Toru , Yoshimoto Takayuki 
Published: March 2021

AbstractAmong various cytokines, interleukin (IL)-12 family cytokines have very unique characteristics in that they are composed of two distinct subunits and these subunits are shared with each other. IL-23, one of the IL-12 family cytokines, consists of p19 and p40 subunits, is mainly produced by antigen-presenting cells, and plays a critical role in the expansion and maintenance of pathogenic helper CD4+T (Th)17 cells. Since we initially found that p19 is secreted in the culture supernatant of activated CD4+T cells, we have further investigated the role of p19. p19 was revealed to associate with CD5 antigen-like (CD5L), which is a repressor of Th17 pathogenicity and is highly expressed in non-pathogenic Th17 cells, to form a composite p19/CD5L. This p19/CD5L was shown to activate STAT5 and enhance the differentiation into granulocyte macrophage colony-stimulating factor (GM-CSF)-producing CD4+T cells. Both CD4+T cell-specific conditional p19-deficient mice and complete CD5L-deficient mice showed significantly alleviated experimental autoimmune encephalomyelitis (EAE) with reduced frequency of GM-CSF+CD4+T cells. During the course of EAE, the serum level of p19/CD5L, but not CD5L, correlated highly with the clinical symptoms. Thus, the composite p19/CD5L is a possible novel heterodimeric cytokine that contributes to EAE development with GM-CSF up-regulation.
A retrospective study of clinical and laboratory features and treatment on cats highly suspected of feline infectious peritonitis in Wuhan, China
Authors: Yin Yiya , Li Ting , Wang Chaohao , Liu Xiaoya , Ouyang Hehao , Ji Wanfeng , Liu Jiahao , Liao Xueyu , Li Junyi , Hu Changmin 
Published: March 2021

AbstractFeline infectious peritonitis (FIP) is a systemic, potentially fatal viral disease. The objectives of this study were to review clinical and laboratory features and treatment of cats highly suspected of FIP in Wuhan, China. The clinical records of 127 cats highly suspected of FIP were reviewed for history, clinical signs, physical findings, and diagnostic test results. Sex, neutering status, breed, age, and month of onset of disease were compared with the characteristics of the clinic population. Age and neutering status were significantly correlated with FIP-suspicion. Sex, breed and onset month were not associated with FIP. There were many more FIP-suspected cases in cats in young cats or male intact cats. Effusion was observed in 85.8% of the FIP-suspected cats. Increased serum amyloid A (SAA) and lymphopenia were common laboratory abnormalities in the FIP cases. Furthermore, 91.7% of the cats highly suspected of FIP had an albumin/globulin (A/G) ratio < 0.6, while 85.3% had an A/G ratio < 0.5. The mortality rate for FIP-suspected cats was 67%, and six submitted cases were confirmed by FIP-specific immunohistochemistry. Of the 30 cats treated with GS-441524 and/or GC376, 29 were clinically cured. The study highlights the diverse range of clinical manifestations by clinicians in diagnosing this potentially fatal disease. A/G ratio and SAA were of higher diagnostic value. GS-441524 and GC376 were efficient for the treatment of FIP-suspected cats.
Mendelian randomization analysis of the association between human blood cell traits and uterine polyps
Authors: Sun Shuliu , Liu Yan , Li Lanlan , Jiao Minjie , Jiang Yufen , Li Beilei , Gao Wenrong , Li Xiaojuan 
Published: March 2021

AbstractHuman blood cells (HBCs) play essential roles in multiple biological processes but their roles in development of uterine polyps are unknown. Here we implemented a Mendelian randomization (MR) analysis to investigate the effects of 36 HBC traits on endometrial polyps (EPs) and cervical polyps (CPs). The random-effect inverse-variance weighted method was adopted as standard MR analysis and three additional MR methods (MR-Egger, weighted median, and MR-PRESSO) were used for sensitivity analyses. Genetic instruments of HBC traits was extracted from a large genome-wide association study of 173,480 individuals, while data for EPs and CPs were obtained from the UK Biobank. All samples were Europeans. Using genetic variants as instrumental variables, our study found that both eosinophil count (OR 0.85, 95% CI 0.79–0.93, P = 1.06 × 10−4) and eosinophil percentage of white cells (OR 0.84, 95% CI 0.77–0.91, P = 2.43 × 10−5) were associated with decreased risk of EPs. The results were robust in sensitivity analyses and no evidences of horizontal pleiotropy were observed. While we found no significant associations between HBC traits and CPs. Our findings suggested eosinophils might play important roles in the pathogenesis of EPs. Besides, out study provided novel insight into detecting uterine polyps biomarkers using genetic epidemiology approaches.
History and Lingering Impact of the Arbitrary 25-dB Cutoff for Normal Hearing
Authors: Gatlin Andrea E. , Dhar Sumitrajit 
Published: March 2021

Purpose
Since its inception nearly a century ago, the audiogram has become the gold standard for reporting an individual's hearing status. The interpretation of the audiogram, namely, where normal hearing ends and hearing loss begins, impacts all areas of audiology: research, clinical, and medicolegal. Where to define normal hearing was the subject of great debate during the early decades of audiology. Revisiting this history reveals how the 25-dB HL cutoff came to be; a decision concerned more with the legal consequences than the scientific persuasiveness of the definition of normal hearing. Since the 1970s, the 25-dB HL cutoff has defined normal-hearing control groups in research and informed treatment recommendations in the clinic.

Conclusions
Today, in 2020, closer evaluation of this so-called normal-hearing group reveals a variety of deficits not captured by the audiogram. The history of how normal hearing came to be defined in conjunction with this growing body of research serves as a good reminder to look beyond the audiogram. This is especially important as the field of audiology looks ahead toward improved diagnostics, earlier detection, and new technologies/treatments.
Soybean production and yield in the context of global climatic changes
Authors: Gonçalves Sergio Luiz , Farias, José Renato Bouças , Sibaldelli Rubson Natal Ribeiro 
Published: March 2021

Abstract

The global context of climate change predicts increases in the risk of important climatic factors that could directly influence plant survival and crop yields. Such projections are made using models of plant growth and development, climate, and possible future scenarios. However, the use of different models and methodologies, combined with different scenarios, produces an infinity of contrasting results, considering different combinations of temperature, water distribution, and CO
2
concentration in the atmosphere. This work makes projections of the possible climatic and environmental effects on the development and the yield of the soybean considering different scenarios. For maintenance and yield improvements, the needs and possibilities of using techniques related to the climate and the use and protection of soils and cultivars already adapted to different environments are emphasized. It is also expected that science will evolve to adapt plants to the expected stresses. Science should act to select genotypes that can respond to stresses by initiating processes that result in the activation of responses at the molecular, biochemical, and physiological level, in the fight to increase tolerance to abiotic stresses. Such advances lead us to believe that the exploration of the existing genetic variability will enable the selection of genotypes tolerant to drought, saline soils, and high temperatures. It is concluded that the set of knowledge that we have today, together with the scientific advances that are yet to come, allows humanity to continue having the hope of having a better future than those predicted in the most pessimistic scenarios.
Study on Micro-Structure and Macro-Mechanical Properties of Bush-Restored Tailings Soil
Authors: Yang Qingchao , Hao Zhe , Cheng Wenjing , Teng Da , Wang Xiaoming , Lei Shengyou 
Published: March 2021

Abstract
Taking the tailings pond repaired by sea buckthorn as an example, the effects of shrub restoration on the microstructure and corresponding macroscopic mechanical properties of tailings soil were studied. Phytoremediation and non-phytoremediation of tailings soil were studied by means of scanning electron microscopy, consolidation, infiltration and shear tests. The results show that: Under the action of phytoremediation, the tailing particles have developed from loose and disorderly to compact and orderly. The distribution of tailings soil aggregates tends to be uniform, and the average particle size of tailings soil aggregates has increased slowly and steadily. The time of phytoremediation increased, but the compressibility and permeability of tailings soil decreased gradually. The compressive modulus of tailings soil was increased gradually. The cohesion of tailings soil was increased firstly and then decreased, but it was greater than that of unrepaired tailings soil. Internal friction angle of tailings soil was the trend of decreasing first and then increasing.
Long-Term Weather Prediction Based on GA-BP Neural Network
Authors: Dou Kening , Sun Xiaoqi 
Published: March 2021

Abstract
A genetic algorithm is used to optimize the weights and thresholds of the BP neural network in this paper, this method improves the disadvantages of the BP neural network. For example, It is insensitive to weights and thresholds. In addition, it has a slow convergence rate and is prone to fall into local minima. etc. To verify the improvement effect, the BP neural networks and the improved BP neural networks were used to simulate the weather in Rizhao city, Shandong Province, respectively. The results of simulation show that the GA-BP neural network model is superior to BP neural network model in the accuracy of temperature prediction in long-term weather. Next, the GA-BP neural network was further optimized by selecting the optimal number of hidden layers and changing the impact factors, and the prediction results were fitted. The analysis shows that the accuracy of the improved GA-BP model in prediction is higher.
The Influence of Nutrient Removal by Different Harvest Time of the Emerged Plant in the Wetland System
Authors: Xiao Liwei 
Published: March 2021

Abstract
In order to avoid the secondary pollution caused by the withering of plants, experiments on reasonable harvesting time of emerged plants in the constructed wetland (CWs) was conducted. The results showed that the best plant regrowth and nutrients removal efficiency by harvested plant were happened when plants were harvested at the withering period (January). Whenever plants were harvested, the removal amount of nitrogen and phosphorus in the CWs was greater than that in the non-harvesting CWs. When plants were harvested at the early growing period, the removal of nitrogen and phosphorus by the CWs reached the maximum, which were 92.39 mg·L−1 and 237.17 mg·L−1, respectively. Therefore, based on the plant regrowth and nutrient removal efficiency of the CWs, it is suggested to harvest emerged plants after the growth period (preferably the withering period), which will be most conductive to the long-term effective operation of the CWs.
Analysis on the Influence of Topography on a Short-Time Local Heavy Rainfall Forecast in Western Xinjiang
Authors: Gao Hua , Bao Dongling , Li Wei , Zheng Zuofang 
Published: March 2021

Abstract
Based on the prediction results of RmAPs-CAV1.0, a short time heavy rainfall in western Xinjiang was simulated and analyzed. By comparing the forecast results with the actual precipitation, it is found that RMAPS-CAV1.0 can accurately reflect the important forecast parameters of the short-time heavy precipitation system, such as precipitation level and starting time. Contrast observation and prediction results found that the terrain has forced effect to the surface wind field, the precipitation process in Yili valley special opening of the west mountain terrain, the center is located in Kazakhstan in central Asia low vortex cause lower for the westerly Yili river valley, the center is located in the Tarim Basin of central Asia for Piandongfeng middle low vortex makes the Yili river valley, cause the Yili river valley and the lower levels of vertical wind shear reinforcement; In the Yili River Valley, the combination of topography and the central Asian vortex circulation in Kazakhstan forms a low-altitude convergence line. The low-level westerly winds transport water vapor into the valley, and the northerly airflow in the valley and the northern margin of the Taklamakan Desert converge near the windward slope, and the enhanced upward movement results in the uplift of the water vapor accumulated in the valley. The result analysis of RMAPS-CAV1.0 shows that the warm and cold airflow and water vapor under the action of topography have important contributions to the generation of this precipitation.
Method of Calculating Lake Water Storage in Areas without Topographical Data Based on Google Earth Engine
Authors: Sun Jiajun , Cui Yingjie , Cao Hongbin 
Published: March 2021

Abstract
Accurate ecological lake water calculation plays an important role in maintaining ecological health of and protecting lakes. However, the lack of topographical data for the bottom of the lake results in some complexity to the calculation of ecological lake water storage. This study uses remote sensing big data to overcome the data limitations of water calculations and accurately calculates the ecological water storage of Baiyangdian Lake. The results show that the water surface area of Baiyangdian Lake can be divided into a dry period (average water area of 7.15 km2), a decline period (155.64 km2), a stable period (67.29 km2), and a recovery period (119.17 km2). The ecological water storage of the lake has evolved from 200 million m3 to the current 300–600 million m3. This study provides an important reference for the ecological lake water calculations when topographical data is not available and for lakes with complex bottom topography.
Modification Works of Impressed Current Cathodic Protection System for Steel Sheet Piles Bulkhead Wharf
Authors: Li Yan , Liu Qiang , Qin Yongkun , Zhu Xichang 
Published: March 2021

Abstract
The steel sheet piles have been protected effectively by the cathodic protection system against seawater corrosion for 40 years. There is no phenomenon of corrosion perforation and corrosion damage. However, many instruments and parts of the cathodic protection system do not work properly now, whilst many new cathodic protection materials are produced and more effective. In order to prevent the steel sheet piles from seawater corrosion, the ICCP system should been modified perfectly.
Study on Influence of High Activity Alkaline Electrolyzed Water on Sulfate Resistance Property of Concrete
Authors: Liu Guibin , Zhang Tianyu , Yu Qi , Li Qiuyi , Wang Liang 
Published: March 2021

Abstract
In this study, a kind of alkaline electrolyzed waters with the pH of 10.5 was used to enhance the sulfate resistance properties of concrete with mineral admixture at different proportioning. The results showed that Alkaline electrolyzed water in concrete can activate the pozzolanic effect of mineral admixtures, leading to an increase of compressive strength. The compressive strengths of electrolyzed water concrete (DJ) were all high than those of natural tap water concrete (TW) at same mineral admixture proportion. Through 120 times of sulfate attack cycles, the sulfate resistance coefficients of TW concrete with different proportions were 90.4~93.7%, and those of DJ concrete is 94.7~96.8%. The sulfate corrosion resistance property of DJ concrete was improved. The corrosion products AFt and gypsum on the surface of concrete were formed by the reaction of Ca2+ in cement paste and free SO4
2- infiltrated into the solution, which would further deepen the internal Ca2+ migration. In order to maintain the overall charge balance, K+ ions in alkaline electrolyzed water moved in, so as to slow down the corrosion of concrete. The SEM micromorphology showed that the internal structure of alkaline electrolyzed water concrete was more dense and compact, the porosity is relatively lower, which was less affected by sulfate corrosion. The microstructure of DJ concrete with mineral admixtures was more developed and denser than TW concrete.
Research on the Cultural Landscape Greenway Model of Water Network City——Taking Suzhou as an Example
Authors: Xu Zixuan , Ma Jianwu 
Published: March 2021

Abstract
Water network cities have special natural ecological characteristics, creating a good living environment. However, as the process of urbanization in my country accelerates, the lack of cultural characteristics and the destruction of the ecological environment have become serious obstacles to the development of water network cities. The harmonious water network bureau has changed in the past, and the contradiction between water cities has become increasingly prominent. The article researches and summarizes the construction principles and design techniques of cultural landscape greenways, and takes the water network city, Suzhou as a case to discuss the key points of the construction of cultural landscape greenways in Suzhou, and provide the cultural landscape greenway network practice in the water network city Provide a certain theoretical guidance.