bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recommendation of RILEM TC 269-IAM: damage assessment in consideration of repair/retrofit-recovery in concrete and masonry structures by means of innovative NDT
Authors: Shiotani Tomoki , Watabe Kazuo ,   RILEM Technical Committee
Published: February 2025

Abstract
This recommendation specifies a method for measuring passive elastic waves and assessing damage to concrete members such as decks and girders. To visualize internal damage, acoustic emissions (AE) and elastic wave velocity are employed. Firstly, based on the data detected by AE sensors, the location of the AE sources is estimated. Then, the velocity distribution in the concrete is evaluated. Accordingly, the internal damage of concrete deck can be evaluated quantitatively by applying a simple procedure using two evaluation axes, which are AE source density and elastic wave velocity in the concrete. Thus, the local deterioration of the concrete member can be classified into several stages that represent the damage levels of internal defects.
Enacting contextually responsive scholarship: Centering occupation in participatory action research with children in India
Authors: Benjamin-Thomas Tanya Elizabeth , Laliberte Rudman Debbie , Thomas David Mark 
Published: February 2025

Occupation-based scholars are striving to mobilize socially responsive scholarship to address occupational injustices from local to global scales. Moving forward involves expanding beyond Western, Anglophonic, female, able-bodied, adult perspectives on occupation, with critically informed participatory methodologies providing one key means to incorporate diverse perspectives on occupation and occupational justice. Drawing upon a participatory action research project with children with disabilities from rural South India, this paper puts forward an understanding of participatory action research as an occupational process (i.e., embodying a variety of occupations) and an occupation-based process (i.e., informed by an occupational lens). We forefront how 'occupation' was centered and mobilized within the process of this participatory action research. In addition, drawing on select study findings, we illustrate and discuss how participatory action research provided a forum to partner with the child co-researchers and collaboratively identify and critically analyse occupational injustices. Through this illustration and discussion of participatory action research as an occupation-based process and occupational process, we demonstrate its potential to be used to enact contextually responsive scholarship and praxis.

Key words: Occupation-Based Participatory Action Research; Occupational Justice; Occupation-Based Transformation; Participatory Filmmaking
Predictors of overdose response hotline use for mental health and fatal overdose prevention
Authors: Rioux Will , Viste Dylan , Orr Taylor , Rider Nathan , Ghosh S. Monty 
Published: February 2025

Abstract

Objectives
The overdose crisis remains one of the largest public health issues facing North America to date. Formalized virtual spotting services have gained popularity as a harm reduction intervention, proving early effectiveness in reducing overdose mortality. This study determined the characteristics of individuals who recurrently use one such service, Canada’s National Overdose Response Service (NORS).

Methods
In this retrospective study, call logs from NORS were analyzed from service inception. Demographics including age, gender, province, community size, substance used, routes of administration, and adverse events were all collected and imputed into a marginal means and rates model to determine the predictors of recurrent service use.

Results
A total of 7340 unique calls were included within our analysis. Of those, 1167 (15.8%) reported their gender as male, 3744 (51.0%) as female, and 1329 (18.1%) as gender diverse, and 1100 (14.9%) did not report their gender. In terms of age, 46 (0.6%) were individuals under the age of 18 years, 3561 (48.5%) were between 18 and 30, 557 (7.6%) were between 31 and 40, 2505 (34.1%) were between 41 and 50, 525 (7.1%) were age 51 or over, and 146 (2.0%) did not report their age. Men’s rate ratios for recurrent calls were significantly lower than women’s (RR = 0.08, 95% CI = 0.07‒0.09), as were those for respondents aged 31‒40 years as compared with those aged 18‒30 (RR = 0.26, 95% CI = 0.15‒0.45). Between regions, rate ratios for callers from British Columbia (RR = 0.28, 95% CI = 0.17‒2.24) and Atlantic provinces (RR = 0.09; 95% CI = 0.07‒0.12) were significantly lower than those for callers from the province of Ontario. Similarly, rural callers demonstrated lower recurrent service use (RR = 0.08; 95% CI = 0.07‒0.11) than their urban counterparts.

Conclusion
NORS demonstrates higher usage patterns within certain demographic groups, in particular, urban women. The results can therefore be used to target public health messaging toward those who derive the most benefit from the service and to tailor programming to those who are at highest risk to use alone.
On a Generalized Alpha Skew Laplace Distribution: Properties and Applications
Authors: Das Jondeep , Hazarika Partha Jyoti , Pathak Dimpal , Sulewski Piotr 
Published: February 2025

This study introduces a novel extension of the alpha skew Laplace distribution (Harandi and Alamatsaz 2013), designed to model datasets with both unimodal and bimodal characteristics effectively. A detailed examination of its statistical properties is conducted, including moments, moment-generating functions, cumulative distribution functions, and characterization results based on conditional distributions. The study also develops a location-scale generalization, enhancing the scope of the distribution for broader applications. Besides, parameter estimation is performed using maximum likelihood methods, supported by a comprehensive analysis of the Fisher Information Matrix, ensuring robust and precise inference.The utility of the new distribution is validated through simulation studies which confirms the asymptotic consistency of its parameter estimates under varying sample sizes. Real-life applications involving white cell count data of Australian athletes and failure times of aircraft windshields demonstrate its superior performance over some established models. The newly introduced model consistently achieves lower Akaike and Bayesian Information Criteria (AIC/BIC) values, confirming its efficacy in fitting complex datasets. Additionally, likelihood ratio tests provide statistical evidence supporting its distinct advantages over nested models. This distribution represents a significant advancement in the field of probability and statistical modeling, offering a robust and versatile tool for analyzing diverse datasets with asymmetric or bimodal traits.
PSYCHOPHYSIOLOGICAL STRESS REACTIVITY OF THE BODY IN RESPONSE TO A COGNITIVE LOAD TEST IN YOUNG HEALTHY INDIVIDUALS: GENDER DIFFERENCES
Authors: Zagorskaya Natalia N. , Shcheglova Anna V. , Sumin Aleksey N. , Prokashko Ingrid Yu. 
Published: February 2025

Highlights The study results revealed gender differences in reactions to psycho-emotional stress in young healthy people, showing that women had higher levels of muscle tension, while men had higher levels of skin conduction. This highlights the importance of taking gender differences into account when assessing stress reactivity and developing stress resilience programs. The data obtained can be used to create an optimal battery of physiological parameters for assessing the dynamics of stress tolerance and developing biofeedback programs for stress management. AbstractAim. To study gender-specific reactions to psycho-emotional stress in young healthy individuals, emphasizing the physiological parameters of the cardiovascular system.Methods. The study included 47 students of Kemerovo State Medical University aged 18 to 32 years. The participants were divided into male (n = 14) and female (n = 33) groups. Psychophysiological diagnostics was performed using the BOSLAB complex: an electromyogram, an electrocardiogram, body temperature, respiration, a galvanic skin reaction and a photoplethysmogram were obtained. The stress testing protocol included cognitive tasks and rest phases.Results. When exposed to stress tests, there was a statistically significant increase in heart rate (HR) and a shortening of the R-R intervals (p < 0.001), as well as an increase in the duration of the respiratory cycle (p = 0.029) and a decrease in the frequency of the respiratory mode (p < 0.001). Gender differences were manifested in higher levels of muscle tension in women (p < 0.001) and higher skin conduction in men (p = 0.033).Conclusion. In young healthy individuals, mental stress causes activation of the sympathoadrenal system, which manifests itself in changes in heart rate and respiratory parameters. Gender differences in stress responses are expressed in differences in muscle tension and skin conduction. This data can be useful for the development of stress tolerance and stress training programs.
THE ROLE OF CORONARY ARTERY MSCT IN ASSESSING CARDIAC RISK IN PATIENTS WITH CANCER BEFORE UPCOMING SURGERY
Authors: Starovoitova Anastasia V. , Shcheglova Anna V. , Sumin Aleksey N. , Gorbunova Elena V. , Kokov Alexander N. 
Published: February 2025

HighlightsThe article shows the positive role of consulting a cardiologist and the prospects of using multispiral computed tomography of the coronary arteries to assess the cardiological risk in patients with cancer before the upcoming surgery. Abstract Aim. To study the possibilities of using multispiral computed tomography (MSCT) of coronary arteries with the following determination of the calcium index for additional risk assessment and risk restratification in patients with cancer before the upcoming surgical intervention.Methods. The pilot study included 26 patients (median age was 68.6 years, 69% men, 31% women) with malignant neoplasms undergoing additional examination and risk stratification before the high-risk surgery. All patients were examined by a cardiologist who assessed the perioperative cardiovascular risk during noncardiac surgery. Moreover, patients underwent the assessment of the pre-test probability (PTP) and the clinical probability of obstructive coronary artery disease (CAD). After that, all patients underwent MSCT of the coronary arteries with determination of the calcium index (50%) or MSCT of the coronary arteries with contrast (50%). In order to establish the severity of the coronary lesion, patients underwent selective coronary angiography (SCA). The randomization of patients was performed taking into account the limitations of contrast-enhanced coronary artery MSCT.Results. When assessing the clinical symptoms of angina pectoris, patients were more likely to have atypical and non-anginal pain (in 38% of cases, respectively) than typical anginal pain (only in 27% of patients). At the same time, the median PTP of obstructive CAD was 24%, which corresponded to a high risk of obstructive CAD. An additional assessment of the clinical probability of CAD classified 61% of patients as a group with a very high probability of obstructive CAD. According to the results of the examination, one patient (4%) with high coronary calcium and 2 patients (8%) with hemodynamically significant stenosis were referred for SCA. Of these, all (100%) patients had significant coronary artery stenosis > 70%. According to the results of the angiographic examination, preventive coronary artery stenting was indicated in two cases, and conservative tactics were chosen in one case.Conclusion. The results of this study highlight the prospects of using MSCT of coronary arteries to assess the cardiological risk in patients with cancer before the upcoming surgery. Such diagnostic and therapeutic tactic may minimize the number of perioperative cardiac complications.
PATTERN OF CIRCULATING MICRORNAS IN VASCULAR COGNITIVE DISORDERS
Authors: Petrova Marina M. , Shnayder Natalia A. , Petrov Artem V. , Kaskaeva Darya S. , Trefilova Vera V. , Nasyrova Regina F. 
Published: February 2025

HighlightsStudying circulating microRNAs in vascular cognitive disorders significantly contributes towards understanding the molecular mechanisms of development and progression of these disorders.Studying microRNAs allows us to identify new biomarkers that can be used to diagnose, predict the course of the disease and determine the effectiveness of treatment. AbstractVascular cognitive disorders (VCD) are one of the most common forms of non-psychotic mental disorders with a variable phenotype and rate of progression, transformation into vascular dementia. VCD develops due to existing cardiovascular diseases (CVD), which highlights the importance of an interdisciplinary approach to diagnosis and treatment of these diseases. The study of new mechanisms of the development of VCD can help in finding the key to the development of innovative diagnostic methods and personalized treatment approaches. In recent years, the role of non-coding ribonucleic acids (RNA) has been actively studied, while the greatest interest of researchers and clinicians is focused on studying the role of microRNAs (miR). The aim of this review was to search, generalize and systematize preclinical and clinical studies on the role of circulating miR as molecular biomarkers of the development and progression of VCD. The authors searched for publications in the following databases PubMed, Springer, Web of Science, ClinicalKey, Scopus, Oxford Press, Cochrane, e-Library using keywords and their combinations. The publications published in 2013–2023 were analyzed, including original clinical studies of VCD and vascular dementia. The findings of this review show that miR-409-3p, miR-502-3p, miR-486-5p and miR-451a can be considered as promising molecular biomarkers of VCD. However, the role of other microRNAs is debatable and needs further study. In the future, it will be possible to consider previously studied circulating microRNAs with high specificity and sensitivity to VCD and vascular dementia as prognostic molecular biomarkers (predictors) of the risk of their development and severity in patients with CVD.Based on the analysis of the results of preclinical and clinical studies, the authors present the most sensitive and specific microRNAs associated with the development and rapid progression of VCD in people with cerebrovascular and cardiovascular diseases. Moreover, microRNAs have been demonstrated to facilitate the differential diagnosis of VCD and cognitive disorders in Alzheimer's disease and Parkinson's disease.
RISK FACTORS FOR HYPERTENSION ASSOCIATED WITH THE FEMALE SEX
Authors: Shmaltz Diana D. , Samus Irina V. , Dovbeta Anna А. , Zvereva Tatyana N. 
Published: February 2025

Highlights Arterial hypertension often develops in women during the perimenopausal period, accompanied by a decrease in estrogen levels and metabolic disorders. It is important to take into account traditional risk factors such as obesity, family history of hypertension and dyslipidemia, and other characteristics of the female body associated with hormonal changes to effectively prevent hypertension in these women. Further study of new risk factors specific to the female population will help improve preventive measures and treatment of hypertension. AbstractAim. To study the prevalence of cardiovascular disease risk factors in women aged 40-50 years, and to evaluate their influence on the development of arterial hypertension (AH).Methods. The study analyzed the medical records of 47 women aged 40 to 50 years who consulted a cardiologist. Patients' complaints were assessed using the Greene climacteric scale, whereas the history of AH and personal medical history, physical examination and laboratory data obtained before the examination were used for analysis.Results. Patients were divided in two groups according to the presence of confirmed АH: the group of patients with AH (n=12), mean age was 45.19 ± 2.86 years; and the group of patients with normal blood pressure (BP, n =35), mean age was 45.30 ± 3.09 years. Age differences between the groups were not significant. 58.3% of patients with AH and 22.8% of patients with normal BP (p = 0.045) suffered from headaches, 83.3% of women with AH and 11.4% of women without AH (p < 0.001) were obese. Family history of AH was more prevalent in the group with AH 75.0% compared with the group with normal BP 34.2% (p < 0.001). 58.3% of patients with AH and 22.6% of patients without AH (p < 0.001) presented with dyslipidemia. Factors such as preterm labour, smoking, excessive salt intake and glycaemic level were not statistically different between groups.Conclusion. The results of the study with a small sample of patients show that for perimenopausal women the most significant factors associated with arterial hypertension are a family history of hypertension, and the need to control body weight and lipidogram parameters. These aspects require attention during the development of preventive measures. Further research on new risk factors associated with female sex is needed to determine their applicability to the Russian population.
Clinical Indicators for Evaluating Japanese Public Hospital Performance: Changes after the Epidemic Phase of Novel Coronavirus Infection
Authors: Moteki Yasutoshi 
Published: February 2025

Abstract

Aim
This study investigates the adoption and implementation of clinical indicators in Japanese public hospitals, focusing on changes since the coronavirus disease 2019 pandemic and utilizing Donabedian's triadic model (structure, process, outcome).
Subject and Methods:
A nationwide postal survey was conducted targeting 848 municipal hospitals with ≥ 20 beds in Japan. The survey explored clinical indicator usage, categorized by Donabedian’s framework. Hospitals were classified based on size to evaluate disparities in indicator adoption. Data were analyzed to compare findings from the current 2024 survey with a similar 2016 survey.
Results
The response rate was 15.7%, with 130 valid responses. Clinical indicator adoption increased from 42.4% (2016) to 58.5% (2024). Large hospitals were more likely to implement clinical indicators (88.1%) than small and medium hospitals (27.0%). Frequently used indicators included average hospitalization duration, bed utilization rates, and clinical pathway coverage. Each structural indicator remained underutilized, with < 15% of hospitals reporting their use.
Conclusion
The findings highlight progress in clinical indicator adoption, particularly in large hospitals. However, significant disparities persist between hospital sizes. As the pandemic subsides, it remains essential to continue improving hospital management practices, including clinical indicator use, in preparation for future infectious disease outbreaks. The three-way model classification for medical evaluation is renowned, but the percentage use of structural indicators has not exceeded 15%, and the implementation status is not as advanced as that of process and outcome indicators. Our results are significant as they verify the explanatory power of the three-way model for medical care based on Japanese data.
Genomic and transcriptomic analyses of melanoma in Japanese patients reveal candidate biomarkers for immune checkpoint inhibitor responders
Authors: Fukushima Satoshi 
Published: February 2025

Abstract

Background
Immune checkpoint inhibitors (ICIs) have greatly improved the prognosis of advanced melanoma. However, the efficacy of ICIs in Japanese patients has been found to be lower than that in Caucasians. We aimed to elucidate the genomic and transcriptomic features associated with the response to ICIs in Japanese patients with melanoma.
Patients and methods
A total of 129 tumor samples from 78 patients with melanoma who received therapeutic regimens with or without ICI treatment were collected from 13 institutions in Japan. We performed exome and RNA sequencing and investigated the association between genomic and transcriptomic factors and the clinical efficacy of ICI therapy. Time-course data were also analyzed. This is the first and largest genomic cohort study in Japanese patients with melanoma in which tumor samples were prospectively analyzed.
Results
The number of somatic SNVs in Japanese patients with melanoma was lower than that in TCGA Caucasian data owing to the biased distribution of WHO subtypes. The driver subtypes BRAF, NRAS, and NF1 were less prevalent, but triple wildtype predominantly existed in the Japanese cohort. An exome-wide survey revealed no significant association of mutated genes with ICI response; however, transcriptomic analysis revealed inflammation-associated genes, including several chemokines and cytokines, that were highly expressed in responders. Follicular helper T cells, estimated by immune cell composition analysis, were significantly enriched in responders (p= 0.0422). Through time-course transcriptome analysis, in addition to several cytotoxic T-cell genes, MARCO on tumor-associated macrophages was found to be induced by ICI treatment in responders (p = 0.0040). Protein expression of these genes was confirmed by immunohistochemical and multiplex immunofluorescence analyses.
Conclusions
Prospective genomic and transcriptomic analyses revealed candidate biomarkers for ICI treatment in Japanese patients with melanoma.
Chronic calculous cholecystitis in situs inverses totalis
Authors: R Anagha T , Hassan Noor ul 
Published: February 2025

Abstract

Situs inversus totalis is a rare congenital abnormality characterised by a mirror-image transposition of both abdominal and thoracic organs. This anatomical disposition of organs not only influences the localisation of symptoms and signs arising from a diseased organ but also imposes special demands on the diagnostic and surgical skills of the surgeon. We present the case of a 28year old woman diagnosed in our hospital with chronic calculous cholecystitis in the presence of situs inversus totalis. After a thorough review of the literature on different positions of the operative team and port sites, the most appropriate and efficient method was chosen. Elective laparoscopic cholecystectomy was performed safely, and the patient was discharged on postoperative day two with no significant postoperative complications.
Identification of the hydrological model of a runoff-sourced falaj using empirical methods
Authors: Al-Ghafri Abdullah , Mohtashami Ali , Khaneiki Majid Labbaf , Al-Breiki Hiba , Al-Mahrooqi Ali Hamood 
Published: February 2025

ABSTRACT
This study examines a historical ghaili falaj named Falaj Al-Sahamah, fed by the runoffs of the Halfeen valley in Izki, Ad-Dakhiliyah governorate. This falaj consists of a subterranean gently sloped tunnel dotted with a row of access wells, the first and deepest of which is sunk at the center of the valley. This research aims to suggest a hydrological model for Falaj Al-Sahamah. To this end, the most crucial step is to estimate the falaj's flowrate using the Manning equation. The dimensions of six undamaged spots along the canal were measured. Our analysis puts an estimate of 48 L/s on the falaj's discharge, pouring into the tank downstream, when the falaj was active. On the opposite side of the tank, two interconnected outlet points are visible, one of which lies at the top and the other at the bottom of the tank. Using Torricelli's law, it transpired that the flowrates of these points depend on the height of water inside the tank, fluctuating between a maximum of 67 and a minimum of 0 L/s. It means that the outflow is greater than the inflow, leaving no water in the tank unless the inflow is more than 67 L/s. This research is key to uncovering agricultural, historical, economic, and social aspects in future studies of the falaj system.