bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dezocine prevents sufentanil-induced respiratory depression during awake intubation: a multicenter, randomized, controlled study
Authors: Pan Xiao , Zou Hongyun , Li Rui , Xia Shujiang , Ju Xia , Zhang Qi , Xu Guanghong , Cheng Xinqi , Gu Erwei , Liu Xuesheng 
Published: March 2021

Abstract
BackgroundSufentanil has sedative and inhibitory effects on the intubation response, but high doses of sufentanil can cause coughing and respiratory depression. Dezocine has been documented effectively suppressing sufentanil-induced cough. Whether dezocine can inhibit the respiratory depression caused by sufentanil is unknown. This study aims to observe the efficacy of dezocine combined with sufentanil in awake intubation.MethodsFour hundred and three patients of American Society of Anesthesiologists physical status Classes I and II, aged 18–65 years, were randomly allocated into four groups: Group saline (saline + 0.4 ug/kg sufentanil), Group D0.05 (dezocine 0.05 mg/kg + 0.4 ug/kg sufentanil), Group D0.10 (dezocine 0.10 mg/kg + 0.4 ug/kg sufentanil), and Group D0.15 (dezocine 0.15 mg/kg + 0.4 ug/kg sufentanil). The primary outcome of our study was to observe the incidence of respiratory depression. Secondary outcomes included the success rate of intubation, ease of intubation, intubation comfort score, sore throat, hoarseness, lethargy, limb movement, glottis exposing and the satisfaction of patients during intubation. Hemodynamic changes were recorded after sufentanil injection and awake intubation.ResultsThere was no difference in the effect of normal saline and 0.05 mg/kg dezocine on respiratory depression (P = 0.603). The incidence of respiratory depression in Group D0.10 and Group D0.15 was lower than that of Group saline. Cough was statistically different between the four groups (P < 0.05). The incidence of cough in the dezocine groups was lower than that of Group saline. There was a significant difference in patient intubation satisfaction between the four groups (P < 0.05). The satisfaction of patients during intubation were significantly higher in the dezocine groups. Sore throat, hoarseness, lethargy and success rate of intubation were similar between the four groups (all P > 0.05).ConclusionsOur study indicated that 0.10 mg/kg and 0.15 mg/kg dezocine might prevent the occurrence of cough and respiratory depression induced by sufentanil during awake intubation and improve patient satisfaction.Trial registrationClinicaltrials.gov (NCT02673723), 2- 4- 2016.
Metabolites from Induratia spp. Modulating Key Enzymes in Human Hemostasis
Authors: Cardoso Mauro Guilherme Barros , Trento Marcus Vinicius Cardoso , Cesar Pedro Henrique Souza , Marcussi Silvana , CARDOSO PATRICIA GOMES 
Published: March 2021

Abstract
Fungi Induratia have been poorly evaluated for their non-volatile secondary metabolites. In the present work, we evaluated the effects of non-volatile secondary metabolites released into the culture medium by Induratia spp. upon toxic alterations induced by Bothrops spp. venoms. B. atrox venom phospholipase was inhibited by Induratia sp. and I. yucatanensis around 12 and 16%. The extracts of two strains inhibited 12 to 25% of the hemolysis induced by B.moojeni venom. Thrombolysis was inhibited by 30 to 60% by the compounds present in two extracts. The coagulation induced by B. moojeni venom was prolonged by 26 to 41 s by the action of the extracts of I. yucatanensis and I. coffeana. The fungal extracts did not exerted any cytotoxic effect, nor did they induce any alteration in the other evaluated substrates show the potential use of non-volatile metabolites produced by the fungi evaluated as enzyme modulators, especially for proteases with a fundamental role in human hemostasis.
&nbsp;‘I Can No Longer Do My Work Like How I Used To’: A Qualitative Longitudinal Cohort Study Exploring How Informal Working Mothers Balance The Requirements Of Livelihood And Safe Childcare In South Africa.&nbsp;
Authors: Horwood Christiane , Hinton Rachael , Haskins Lyn , Luthuli Silondile , Mapumulo Sphindile , Rollins Nigel 
Published: March 2021

Abstract
Background: Returning to work after childbirth is challenging for working mothers. The quality of childcare may have lifelong effects on children’s health, development and cognitive function. Over 60% of working women globally are informal workers without employment or maternity protections, but little is known about how these women care for their children. Methods: We conducted a mixed methods longitudinal cohort study among informal women workers in Kwazulu-Natal, South Africa between July 2018 and August 2019. Participants were followed up from late pregnancy until they had returned to work. We conducted structured quantitative interviews and in-depth qualitative interviews before and after the baby was born, and after returning to work. We then brought groups of participants together for a photovoice activity to explore the childcare environment. Thematic analysis was used to analyse qualitative data in NVIVO v12.4 and SPSSv26 was employed to analyse quantitative data. Results: Women returned to work soon after the baby was born, often earlier than planned, because of financial responsibilities to provide for the household and the new baby. Women had limited childcare choices and most preferred to leave their babies with family members at home, as the most convenient, low cost option. Otherwise, mothers chose paid carers or formal childcare. However, formal childcare was reported to be poor quality, unaffordable and not suited to needs of informal workers. Mothers expressed concern about carers’ reliability and the safety of the childcare environment. Flexibility of informal work allowed some mothers to adapt their work to care for their child themselves, but others were unable to arrange consistent childcare, sometimes leaving the child with unsuitable carers to avoid losing paid work. Mothers were frequently anxious about leaving the child but felt they had no choice as they needed to work. Conclusion: Mothers in informal work had limited childcare options and children were exposed to unsafe, poor-quality care. Maternity protection for informal workers would support these mothers to stay home longer to care for themselves, their family and their baby. Provision of good quality, affordable childcare would provide stability for mothers and give these vulnerable children the opportunity to thrive.
Basal serum follicle-stimulating hormone and anti-mullerian hormone are the predictors of poor ovarian response among fertile and infertile women below the age of 40 years&nbsp;
Authors: Khan Haroon Latif , Bhatti Shahzad , Imrana  , Humera  , Shuail Samina 
Published: March 2021

Abstract
Infertility is defined as the inability to conceive despite having frequent, unprotected sex for at least one year. The failure to have children affects men and women across the globe. Infertility can lead to distress and depression [1]. The clinical definition of infertility used by the World Health Organization (WHO) is "a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse" [2], while the WHO's epidemiologic definition is "women of reproductive age at risk of becoming pregnant who report unsuccessfully trying for a pregnancy for more than two years" [3]. Clinical definitions are designed for early detection and treatment of infertility [2]–[4]. A progressive decline in fecundity occurs in both males and females with advancing age. Generally, male factors contribute to one-third of infertility cases, the other one-third occurs due to female reproductive deficiencies, while in remaining cases, both male and female causes equally contribute towards infertility. In some cases, infertility is iatrogenic in nature as both male and female profile comes out to be normal and termed as unexplained infertility.
Integrated computational analysis revealed hub genes in lung adenocarcinoma
Authors: Jamal Muhammad , Khan Abdul Saboor , Bangash Hina Iqbal , Xie Tian , Song Tianbao , Lei Yufei , Li Jingyuan , Tan Haiyan , Zhang Qiuping 
Published: March 2021

Abstract
Background

Lung cancer (LUCA) is the leading cause of cancer-related morbidities and mortalities globally. Despite the recent advancements in lung cancer research, understanding of the molecular mechanism underlying LUCA tumorigenesis and prognosis remains suboptimal. This study aims to identify the candidate biomarkers and therapeutic genes in lung cancer.
Methods

In this study, gene expression profiles of GSE30219, GSE33532, GSE32863 and GSE43458 were downloaded from GEO. The differentially expressed genes (DEGs) in LUAD tissue and normal lung tissue with a p-value < 0.05 and a |log fold change (FC)| >1.0 were identified by GEO2R. For functional enrichment analysis of these DEGs, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed with KOBAS and DAVID tools. Next, the candidate hub genes were filtered out with Cytoscape using CytoHubba plugin. These hub genes were validated by (the Cancer Genome Atlas) TCGA-based gene expression analysis, protein-protein network interaction (PPI) analysis, survival analysis. Moreover, the expression of these genes in cancer and normal tissue was assessed in the Human Protein Atlas (HPA) database. In addition, miRNA network of the hub genes was constructed. Finally, DGIdb database was used to check the drug-targeting potentials of the hub genes.
Results

a total of 332 overlapping differentially expressed genes (DEGs) including 73 upregulated and 259 downregulated, respectively were identified. GO analysis revealed that the DEGs were principally regulating various cancer-associated functions and pathways. The module analysis revealed 55 hub genes in 4 modules. The survival analysis through Kaplan-Meier (KM) plotter indicated that the altered expression of these genes resulted in the poor overall survival (OS) of LUCA patients. Moreover, these genes show a differential expression on both protein and mRNA level in cancer patient compared to the normal. In addition, in addition, 6 potential microRNAs (miRNAs) interacting with hub genes were identified. Finally, a list of 117 therapeutic small molecules was tabulated that could facilitate LUCA treatment.
Conclusions

the findings of this study may help in the development of novel and reliable biomarkers for diagnosis, prognosis and therapeutic intervention for LUAD.
Avascular Necrosis of Humeral Trochlea: A Case Report of the Rare Condition
Authors: Yilmaz Temel Fatih , Okutan Ahmet Emin , Ayas Muhammet Salih , Dada Mehmet Emin , Turhan Ahmet Uğur 
Published: March 2021

İntroduction:
Avascular necrosis of humeral trochlea is a very rare condition and was
described by Hegemann in 1957. We reported two cases of avascular necrosis of humeral trochlea
and also performed a literature review of the reported cases. We expect that this case report will assist
clinicians in making a timely diagnosis when encountering similar clinical scenarios.

Materials and Methods:
We presented cases of an 11-year-old and a 14-year-old with avascular necrosis
of the humeral trochlea. The common etiology was idiopathic because there were no recent
trauma history and sports activity. Also, there was no history of drug use. We discussed the clinical
and radiological findings of these cases.

Results:
These cases, two teenage boys, were diagnosed withHegemann’s disease with clinical and
radiological outcomes. We found that the etiology of both thecases is idiopathic;. The number of
previously reported cases in the literature is limited to 64. In our study, there was a lateral crest in
one of our two cases and a posteromedial involvement in another. The radiograph of trochleae of these
two cases showed irregularity and granular appearance. In our case, heterogeneous signal
changed and irregularities were accompanied by hypointensive changes on T1-weighted images.
Also, hyperintensive changes on proton density sequences were detected.

Conclusion:
Radiological evaluation plays an important role in the diagnosis and evaluation of response
to treatment in avascular necrosis of the humeral trochlea. Avascular necrosis should be one
of the differential lesions involving the trochlea. Recognition of avascular necrosis in the trochlea
may prevent the unnecessary biopsy.
MANAJEMEN KULTUR SEKOLAH DALAM UPAYA PENINGKATAN MUTU PENDIDIKAN DI SMA NEGERI 2 BREBES
Authors: Saputri Evi Rovikoh Indah 
Published: March 2021

Salah satu upaya yang dilakukan sekolah untuk meningkatkan prestasi siswa adalah mengembangkan kultur sekolah. Artikel ini bertujuan untuk menyajikan manajemen kultur sekolah di SMAN 2 Brebes sebagai upaya peningkatan mutu pendidikan yang meliputi kultur berprestasi, berkarakter, dan kegiatan ekstrakurikuler. Penelitian ini menggunakan pendekatan kualitatif dengan teknik pengumpulan data berupa observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa manajemen kultur sekolah dilakukan dengan mengembangkan kultur berprestasi, berkarakter, dan kegiatan ekstrakurikuler. Kultur Berprestasi dilaksanakan dengan kompetisi akademik, non-akademik, keikutsertaan lomba, pembelajaran efektif. Kultur berkarakter dilaksanakan dengan 18 nilai karakater yang harus dimiliki oleh warga sekolah serta kegiatan pembiasaan. Kegiatan ekstrakurikuler dilaksanakan meliputi kegiatan wajib dan pilihan. Upaya tersebut dilandasi oleh keinginan sekolah untuk berprestasi dalam rangka membangun kepercayaan masyarakat bahwa sekolah mampu mencetak siswa yang berprestasi dan menjadi kebanggaan.Kata kunci: Manajemen, Kultur sekolah, Mutu pendidikan
Tradisi masyarakat pasca gempa 2006 di sriharjo
Authors: Maryani Maryani , Nurhayati Riana 
Published: March 2021

Penelitian ini bertujuan untuk untuk memperoleh pemahaman tentang terjadinya pergeseran tradisi masyarakat pasca gempa 2006 di Sriharjo. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan jenis studi kasus. penelitian ini dilaksanakan di desa Sriharjo, dusun Mojohuro yang terdiri dari 6 RT dengan jumlah penduduk 857 jiwa dan 264 kepala keluarga dengan menggunakan purposive sampling maka terpilih 1 informan kunci dan 3 informan pendukung.Penelitian ini mengunakan 2 jenis sumber data yakni data primer dan data sekunder, Data primer merupakan data yang diperoleh dengan cara observasi dan wawancara. Data sekunder merupakan data yang diperoleh dengan cara mengkaji dokumen. Teknik analisis data menggunakan teori interaktif miles Huberman. Keabsahan data menggunakan triangulasi sumber dan teknik. Hasil penelitian menunjukkan bahwa tradisi yang berkembang dalam masyarakat Mojohuro, Sriharjo dapat di kelompokkan menjadi 3 hal yakni: 1) Tradisi yang terkait langsung dengan alam. 2) Tradisi yang terkait dengan tahap perkembangan kehidupan manusia. 3) Tradisi yang berasal dari lokal.
Early Prediction of Unplanned 30-Day Hospital Readmission: Model Development and Retrospective Data Analysis
Authors: Zhao Peng , Yoo Illhoi , Naqvi Syed H 
Published: March 2021

Background
Existing readmission reduction solutions tend to focus on complementing inpatient care with enhanced care transition and postdischarge interventions. These solutions are initiated near or after discharge, when clinicians’ impact on inpatient care is ending. Preventive intervention during hospitalization is an underexplored area that holds potential for reducing readmission risk. However, it is challenging to predict readmission risk at the early stage of hospitalization because few data are available.

Objective
The objective of this study was to build an early prediction model of unplanned 30-day hospital readmission using a large and diverse sample. We were also interested in identifying novel readmission risk factors and protective factors.

Methods
We extracted the medical records of 96,550 patients in 205 participating Cerner client hospitals across four US census regions in 2016 from the Health Facts database. The model was built with index admission data that can become available within 24 hours and data from previous encounters up to 1 year before the index admission. The candidate models were evaluated for performance, timeliness, and generalizability. Multivariate logistic regression analysis was used to identify readmission risk factors and protective factors.

Results
We developed six candidate readmission models with different machine learning algorithms. The best performing model of extreme gradient boosting (XGBoost) achieved an area under the receiver operating characteristic curve of 0.753 on the development data set and 0.742 on the validation data set. By multivariate logistic regression analysis, we identified 14 risk factors and 2 protective factors of readmission that have never been reported.

Conclusions
The performance of our model is better than that of the most widely used models in US health care settings. This model can help clinicians identify readmission risk at the early stage of hospitalization so that they can pay extra attention during the care process of high-risk patients. The 14 novel risk factors and 2 novel protective factors can aid understanding of the factors associated with readmission.
A Learning Opportunity by TVOntario
Authors: May Steven James 
Published: March 2021

Background:Sparked by a short-lived plan by the Ontario Educational Communications Authority (known as TVOntario or TVO) to reduce its slate of nine digital over-the-air transmitters to a single transmitter broadcasting from Toronto’s CN Tower, this article questions why some viewers continue to rely on TVO’s transmitters for access. Analysis:This article provides analysis of findings from a 2018 study regarding the role that TVO’s transmitters play in the provision of access to its programming. Conclusion and implications:Analysis of the viewing experiences shared by the research participants identifies four access themes related to infrastructure concerns, monetary concerns, educational concerns, and geographic concerns outside of the Greater Toronto Area.
تغير المعادلات الأمنية في ظل إستراتيجية أمن الطاقة
Authors: Mohammed Shallaw A. , Aqrawi Najdat S. 
Published: March 2021

في الوقت الحاضر، يعتبر عامل الطاقة أحد أهم العوامل الجيوبوليتيكية التي تؤثر على أمن واستقرار مناطق مختلفة من العالم، ولاسيما تلك الغنية بالنفط والغاز الطبيعي. لذلك، يدور هذا البحث حول إظهار طبيعة العلاقة بين مصلحة الطاقة والتغيرات التي تحصل في المعادلات الأمنية للدول بسبب الطاقة، وهو ما يؤثر بدوره على خلق حالة من الاستقرار واللاإستقرار الأمني للبلدان المصدرة والموردة للطاقة. من خلال هذا البحث، نتجاوز الدراسات الحديثة الأخرى حول هذا الموضوع، ونربط أهم عناصر أمن الطاقة بالمعادلات الإستقرار وللا استقرار للدول المصدرة والموردة للطاقة. وبالتالي، فإننا نحلل ما يدفع الدول المصدرة والموردة للطاقة بأن تؤثر على ديناميات تغير المعادلات الأمنية من أجل تأمين المصلحة الطاقوية لبلادهم. الى أن توصل البحث في ختامه الى هذه الحقيقة وهي، رغم نجاح بعض الدول في استخدام الطاقة كقوة صلبة لضمان الاستقرار الأمني لبلدانهم، فأنه بصورة عامة الدول المصدرة والموردة للطاقة ومن أجل تأمين أمن الطاقة، غيروا معادلاتهم الأمنية، وهذا أدى إلى خلق حالة من اللاإستقرار الأمني للدول على المستويات الوطنية والإقليمية وحتى الدولية.
Adolescencia e intimidades: narrativas en transición
Authors: Nava-Preciado José María 
Published: March 2021

El autor explora en este artículo las valoraciones de los/as adolescentes acerca de la intimidad y analiza, a partir de ellas, cómo se configuran y se implican las relaciones afectivas en la actualidad. Enmarcada en el paradigma interpretativo, la investigación recupera el trabajo de campo realizado mediante grupos de discusión y entrevistas semiestructuradas con estudiantes de escuelas preparatorias de la Zona Metropolitana de Guadalajara, México. Los relatos obtenidos sugieren que las relaciones íntimas se tejen, en gran parte, alrededor de las redes sociales, lo que provoca el ensayo de tramas narrativas que sustituyen los relatos dominantes que durante mucho tiempo se posicionaron como infalibles y como únicos para organizar los modos de vivir las intimidades.
Развилки судьбы фронтирного города: уроки Игарки
Authors: Замятина Н. Ю. 
Published: March 2021

<span>На примере Игарки</span><span class="myHorizontalScaleForEmDashSpaceBefore"> </span><span>–</span><span class="myHorizontalScaleForEmDashSpaceAfter"> </span><span>города, с создания которого началось промышленное использование Северного морского пути для экспорта сырья</span><span class="myHorizontalScaleForEmDashSpaceBefore"> </span><span>–</span><span class="myHorizontalScaleForEmDashSpaceAfter"> </span><span>рассматривается механизм эволюции фронтирного города. Под фронтирным понимается город, созданный в районе нового освоения в связи с вводом в оборот нового вида ресурса. После первой, пионерной, фазы развития такой город эволюционирует по одному из двух сценариев: либо формирования монопрофильного поселения, либо развития города-базы дальнейшего освоения. Монопрофильный город эффективен на небольшом отрезке времени, но при истощении ресурса или изменении условий его эксплуатации теряет жизнеспособность. База освоения обеспечивает условия эксплуатации все новых ресурсов, по сути</span><span class="myHorizontalScaleForEmDashSpaceBefore"> </span><span>–</span><span class="myHorizontalScaleForEmDashSpaceAfter"> </span><span>воспроизводства фронтира. Именно такие функции могут сохраниться в городе по исчерпании первоначального ресурса. Игарка пошла по первому пути, и автор задается вопросом, насколько предопределенным был этот выбор.</span>
Совершенствование организационной модели электросетевого комплекса: зарубежный опыт и российская практика
Authors: Файн Б. И. 
Published: March 2021

<span>В статье рассмотрены особенности организации деятельности распределительного электросетевого комплекса в Российской Федерации и ряде зарубежных стран. Дан обзор основных моделей организации такого комплекса, нашедших применение в мировой практике. Проанализированы предпосылки и результаты первого этапа консолидации отечественного электросетевого комплекса. Дана оценка динамики консолидации и концентрации рынков электросетевых услуг в разрезе субъектов Федерации. Выявлены проблемы, связанные с практической реализацией планов консолидации. Обоснована необходимость совершенствования механизмов консолидации электросетевого комплекса РФ, представлены соответствующие предложения и рекомендации.</span>