bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fire buckling curves for torsionally sensitive steel members subjected to axial compression
Authors: Possidente Luca , Tondini Nicola , Battini Jean-Marc 
Published: October 2021

PurposeBuckling should be carefully considered in steel assemblies with members subjected to compressive stresses, such as bracing systems and truss structures, in which angles and built-up steel sections are widely employed. These type of steel members are affected by torsional and flexural-torsional buckling, but the European (EN 1993-1-2) and the American (AISC 360-16) design norms do not explicitly treat these phenomena in fire situation. In this work, improved buckling curves based on the EN 1993-1-2 were extended by exploiting a previous work of the authors. Moreover, new buckling curves of AISC 360-16 were proposed.Design/methodology/approachThe buckling curves provided in the norms and the proposed ones were compared with the results of numerical investigation. Compressed angles, tee and cruciform steel members at elevated temperature were studied. More than 41,000 GMNIA analyses were performed on profiles with different lengths with sections of class 1 to 3, and they were subjected to five uniform temperature distributions (400–800 C) and with three steel grades (S235, S275, S355).FindingsIt was observed that the actual buckling curves provide unconservative or overconservative predictions for various range of slenderness of practical interest. The proposed curves allow for safer and more accurate predictions, as confirmed by statistical investigation.Originality/valueThis paper provides new design buckling curves for torsional and flexural-torsional buckling at elevated temperature since there is a lack of studies in the field and the design standards do not appropriately consider these phenomena.
Global presence of open-source research data management platform for libraries: the Dataverse project
Authors: Jamwal Vineet , Kaur Simran 
Published: October 2021

Purpose
This paper aims to provide statistical information on the worldwide spread of the open-source research data management application, the Dataverse Project, to librarians, data managers and information managers who are considering using the application at their own institution.

Design/methodology/approach
To produce a list of dataverse repositories, the official Dataverse website was evaluated, and JSON data were downloaded and parsed. Data standardisation was performed to assess the state of installations in various nations and continents across the world.

Findings
Globally, the Dataverse repositories have seen a rise in overall installations. The year 2020 alone saw a 23.21% rise. In a country-by-country comparison, the USA (13) has the most dataverse installations, while Europe (25) has the highest number of installations worldwide.

Originality/value
This research will be useful to librarians, data managers and information managers, among others, who want to learn more about Dataverse repositories throughout the world before deploying at their local level.
Do the diversification of income and assets spur bank profitability in Bangladesh? A dynamic panel data analysis
Authors: Uddin Mohammad Jashim , Majumder Md. Tofael Hossain , Akter Aklima , Zaman Rabaya 
Published: October 2021

Purpose
This paper aims to explore the effects of bank diversification (i.e. diversification of income and diversification of assets) on Bangladeshi banks’ profitability.

Design/methodology/approach
Using a dynamic panel data model with system generalized methods of moments, the authors examine an unbalanced panel data from 32 banks spanning 318 bank-year observations from 2007 to 2016.

Findings
The findings indicate a significant positive association of income diversification and asset diversification on bank profitability. Therefore, the results show that banks can generate profit from diversification of income and diversification of assets.

Originality/value
One of the rare attempts to investigate the relationship between diversification and profitability in Bangladesh’s banking sector is this report. The authors anticipate the results to have major consequences for Bangladeshi bank regulators and other related economies.
Virus diversity in metagenomes of a lichen symbiosis (Umbilicaria phaea): complete viral genomes, putative hosts and elevational distributions
Authors: Merges Dominik , Dal Grande Francesco , Greve Carola , Otte Jürgen , Schmitt Imke 
Published: October 2021

SummaryViruses can play critical roles in symbioses by initiating horizontal gene transfer, affecting host phenotypes, or expanding their host's ecological niche. However, knowledge of viral diversity and distribution in symbiotic organisms remains elusive. Here we use deep‐sequenced metagenomic DNA (PacBio Sequel II; two individuals), paired with a population genomics approach (Pool‐seq; 11 populations, 550 individuals) to understand viral distributions in the lichen Umbilicaria phaea. We assess (i) viral diversity in lichen thalli, (ii) putative viral hosts (fungi, algae, bacteria) and (iii) viral distributions along two replicated elevation gradients. We identified five novel viruses, showing 28%–40% amino acid identity to known viruses. They tentatively belong to the families Caulimoviridae, Myoviridae, Podoviridae and Siphoviridae. Our analysis suggests that the Caulimovirus is associated with green algal photobionts (Trebouxia) of the lichen, and the remaining viruses with bacterial hosts. We did not detect viral sequences in the mycobiont. Caulimovirus abundance decreased with increasing elevation, a pattern reflected by a specific algal lineage hosting this virus. Bacteriophages showed population‐specific patterns. Our work provides the first comprehensive insights into viruses associated with a lichen holobiont and suggests an interplay of viral hosts and environment in structuring viral distributions.
Edible coatings as osmotic dehydration pretreatment in nutrient‐enhanced fruit or vegetable snacks development: A review
Authors: Kowalska Hanna , Marzec Agata , Domian Ewa , Kowalska Jolanta , Ciurzyńska Agnieszka , Galus Sabina 
Published: October 2021

AbstractEdible coatings (ECs) are thin layers applied on food to protect it and improve quality. They are made from bio‐based materials such as polysaccharides, proteins, lipids, or their composites. The incorporation of functional agents, such as bioactive compounds, vitamins, or antimicrobials into the EC, has been investigated to control the shelf life of many food products from horticulture ones to processed food. Osmotic dehydration (OD) as a mild technology may also positively impact the availability of innovative fruit snacks and consequently influence consumer health. Combination of the EC with the OD aims to remove water through the semipermeable membrane while limiting the transfer of solutes from the dehydrated tissue and in the opposite direction from the osmotic solution to the food. The development trend of the snack market is expanding, especially with health‐promoting properties. Consumers pay increasing attention to quality of food and its beneficial effects on health. This review attempts to provide the advancement of recent studies on the application of the EC before the OD of different fresh or fresh‐cut fruit and vegetables. A fundamental theory related to the methodology of creating the EC, their composition, and the influence on the physicochemical properties of products that are osmo‐dehydrated to a medium water content or additionally dried to a low water content have been described. Efforts have been exerted to introduce hydrocolloids used in the production of the EC, including new sources of biopolymers such as agricultural waste and by‐products. The perspectives of using ECs in the technology of producing pro‐healthy snacks are emphasized.
Is extended release naltrexone superior to buprenorphine‐naloxone to reduce drinking among outpatients receiving treatment for opioid use disorder? A secondary analysis of the CTN X:BOT trial
Authors: Roache John D. , Pavlicova Martina , Campbell Aimee , Choo Tse‐Hwei , Peavy Michelle , Kermack Andrea S. , Nunes Edward V. , Rotrosen John 
Published: October 2021

AbstractBackgroundThe comparative effectiveness of extended‐release naltrexone versus buprenorphine‐naloxone for opioid relapse prevention (X:BOT) trial showed that following induction, treatment with the sublingual agonist (buprenorphine‐naloxone, BUP‐NX) or injected antagonist (extended release naltrexone, XR‐NTX) produced similar reductions in opioid relapse in injection users with opioid use disorder (OUD). Because XR‐NTX reduces drinking in alcohol use disorder (AUD), we conducted a secondary analysis of the X:BOT sample of patients successfully inducted onto treatment to determine whether XR‐NTX (n = 204) was superior to BUP‐NX (n = 270) in reducing drinking or heavy drinking in patients with OUD.MethodsStandard drink units consumed were measured using the Timeline Follow‐back method. Mixed‐models regression was used to examine the monthly frequency of any drinking and heavy drinking over 6 months of treatment. We used a proportional hazard survival analysis to examine the time to first drink.ResultsBoth treatment groups reduced drinking from baseline to posttreatment (small to medium effect), but no differences between groups were detected. However, only 29% (n = 136) of the sample had AUD and 19% (n = 26/136) of those were abstinent before treatment. Analysis of a subsample enriched for possible drinking included 136 individuals with an AUD diagnosis plus 43 who did not have AUD, but reported at least one day of heavy drinking prior to the study. However, this subsample reported only 32% of days of any drinking with a median of only 13% of days designated as “heavy.” Within this subsample, at baseline, the BUP‐NX group reported more mean drinks per drinking day than the XR‐NTX group (p = 0.03); however, there were no other significant group differences on drinking observed before, during, or at the end of treatment.ConclusionsThere was an overall reduction in drinking during treatment of OUD using both agonist and antagonist medications, so that the hypothesis that XR‐NTX would be superior to BUP‐NX was not supported. The study is limited by low levels of comorbid AUD or heavy drinking observed in X:BOT trial participants seeking treatment for OUD.
Neurobeachin, a promising target for use in the treatment of alcohol use disorder
Authors: Cuzon Carlson Verginia C. , Aylwin Carlos F. , Carlson Timothy L. , Ford Matthew , Mesnaoui Houda , Lomniczi Alejandro , Ferguson Betsy , Cervera‐Juanes Rita P. 
Published: October 2021

AbstractHazardous, heavy drinking increases risk for developing alcohol use disorder (AUD), which affects ~7% of adult Americans. Thus, understanding the molecular mechanisms promoting risk for heavy drinking is essential to developing more effective AUD pharmacotherapies than those currently approved by the FDA. Using genome‐wide bisulfate sequencing, we identified DNA methylation (DNAm) signals within the nucleus accumbens core (NAcC) that differentiate nonheavy and heavy ethanol‐drinking rhesus macaques. One differentially DNAm region (D‐DMR) located within the gene neurobeachin (NBEA), which promotes synaptic membrane protein trafficking, was hypermethylated in heavy drinking macaques. A parallel study identified a similar NBEA D‐DMR in human NAcC that distinguished alcoholic and nonalcoholic individuals. To investigate the role of NBEA in heavy ethanol drinking, we engineered a viral vector carrying a short hairpin RNA (shRNA) to reduce the expression of NBEA. Using two murine models of ethanol consumption: 4 days of drinking‐in‐the‐dark and 4 weeks of chronic intermittent access, the knockdown of NBEA expression did not alter average ethanol consumption in either model. However, it did lead to a significant increase in the ethanol preference ratio. Following withdrawal, whole‐cell patch clamp electrophysiological experiments revealed that Nbea knockdown led to an increase in spontaneous excitatory postsynaptic current amplitude with no alteration in spontaneous inhibitory postsynaptic currents, suggesting a specific role of NBEA in trafficking of glutamatergic receptors. Together, our findings suggest that NBEA could be targeted to modulate the preference for alcohol use.
Evaluation of the outcome of apexogenesis in traumatised anterior and carious posterior teeth using mineral trioxide aggregate: a 5‐year retrospective study
Authors: Mousivand Shima , Sheikhnezami Mahshid , Moradi Saeed , Koohestanian Niloufar , Jafarzadeh Hamid 
Published: October 2021

AbstractThe purpose of this study was to evaluate the outcome of apexogenesis with mineral trioxide aggregate (MTA) in traumatised anterior and carious posterior teeth over 5 years. A comprehensive chart review was performed to obtain a retrospective of sequential previously completed cases with recalls. Clinical and radiographic data were collected for 97 vital immature teeth (40 traumatised anterior and 57 carious posterior teeth) pulpotomised (partial or full pulpotomy) using MTA with an average follow‐up time of 5 years. Chi‐squared test and Fisher’s exact test were implemented to analyse data. The success rate in anterior teeth and posterior teeth was 82.5% and 96.4% respectively. Crown discolouration was observed in 25 (62.5%) anterior teeth. There was a significant difference between the number of successful and unsuccessful cases (P < 0.05) and there was no correlation between type of treatment and success/failure (P > 0.05). The success rate of apexogenesis using MTA in immature teeth was relatively high.
Quantitative evaluation of aerosol generation during manual facemask ventilation
Authors: Shrimpton A. J. , Brown J. M. , Gregson F. K. A. , Cook T. M. , Scott D. A. , McGain F. , Humphries R. S. , Dhillon R. S. , Reid J. P. , Hamilton F. , Bzdek B. R. , Pickering A. E. ,   the AERATOR study group
Published: October 2021

SummaryManual facemask ventilation, a core component of elective and emergency airway management, is classified as an aerosol‐generating procedure. This designation is based on one epidemiological study suggesting an association between facemask ventilation and transmission during the SARS‐CoV‐1 outbreak in 2003. There is no direct evidence to indicate whether facemask ventilation is a high‐risk procedure for aerosol generation. We conducted aerosol monitoring during routine facemask ventilation and facemask ventilation with an intentionally generated leak in anaesthetised patients. Recordings were made in ultraclean operating theatres and compared against the aerosol generated by tidal breathing and cough manoeuvres. Respiratory aerosol from tidal breathing in 11 patients was reliably detected above the very low background particle concentrations with median [IQR (range)] particle counts of 191 (77–486 [4–1313]) and 2 (1–5 [0–13]) particles.l‐1, respectively, p = 0.002. The median (IQR [range]) aerosol concentration detected during facemask ventilation without a leak (3 (0–9 [0–43]) particles.l‐1) and with an intentional leak (11 (7–26 [1–62]) particles.l‐1) was 64‐fold (p = 0.001) and 17‐fold (p = 0.002) lower than that of tidal breathing, respectively. Median (IQR [range]) peak particle concentration during facemask ventilation both without a leak (60 (0–60 [0–120]) particles.l‐1) and with a leak (120 (60–180 [60–480]) particles.l‐1) were 20‐fold (p = 0.002) and 10‐fold (0.001) lower than a cough (1260 (800–3242 [100–3682]) particles.l‐1), respectively. This study demonstrates that facemask ventilation, even when performed with an intentional leak, does not generate high levels of bioaerosol. On the basis of this evidence, we argue facemask ventilation should not be considered an aerosol‐generating procedure.
Scales of Justice: “International Standards” and “Local Ownership” at a Hybrid Tribunal
Authors: Hughes Rachel , Elander Maria 
Published: October 2021

AbstractThis paper argues that a politics of scale plays a fundamental but uninterrogated role in internationalised criminal justice processes such as hybrid tribunals. Scale discourses—producing specific notions of “the international” and “the local”—are so naturalised in these endeavours that their regressive effects remain unacknowledged. Following Annelise Riles’ ground‐breaking analysis of the politics of scale in colonial law, and feminist critiques of scale discourse in accounts of globalisation and conflict, we think critically about “the international” and “the local” in a postcolonial and post‐conflict justice context. Using the case of the Extraordinary Chambers in the Courts of Cambodia (ECCC), we specifically examine the operation and effects of discourses of “international standards” and “local ownership”. We argue that denaturalising scale in international criminal justice would serve a wider project to decolonise international law and address the specific forms of disenfranchisement currently enacted by dominant “scales of justice”.
Contemporary outcomes of durable ventricular assist devices in adults with congenital heart disease as a bridge to heart transplantation
Authors: Das Bibhuti B. , Kogon Brian , Deshpande Shriprasad R. , Slaughter Mark S. , Trivedi Jaimin R. 
Published: October 2021

AbstractObjectivesThis study aimed to compare the clinical characteristics, risk factors, and overall survival outcomes in adults with congenital heart disease (ACHD) bridged to transplantation with a ventricular assist device (VAD) versus no‐VAD.MethodsThe study included 894 ACHD patients aged ≥18 years listed for primary heart transplantation between 2010 and 2019 from the United Network for Organ Sharing database. Primary outcomes were waitlist and 1‐year post‐transplant mortality between VAD and no‐VAD ACHD patients.ResultsOf 894 ACHD patients included in the study, 91(10.1%) had VAD support at the time of listing. Patients who needed VAD support were mostly males, heavier, and had higher pulmonary artery pressure than the no‐VAD group at the listing. The overall waitlist mortality was 38% in the VAD group than 17% in the no‐VAD group (p < 0.01). ECMO use was associated with significantly higher mortality than either group. There was no significant difference in 1‐year post‐transplant mortality between VAD versus no‐VAD at the time of transplant (15% vs. 17%; p = 0.66). Multivariate regression analysis found that BMI <20 kg/m2 (hazard ratio (HR) 1.1; p = 0.01), bilirubin >2 mg/dl (HR 1.1; p = 0.03), creatinine >2 mg/dl (HR 1.3; p = 0.04) and ECMO at transplant (HR 1.4; p = 0.03) increased early post‐transplant mortality.ConclusionsThe one‐year post‐transplant mortality rate was no different for ACHD patients that received VAD versus no‐VAD. These findings suggest that a VAD should be considered an option to support ACHD patients as a bridge to heart transplantation.
Epithelial–mesenchymal transition‐related serum markers ET‐1, IL‐8 and TGF‐β2 are elevated in a Finnish wet age‐related macular degeneration cohort
Authors: Liukkonen Mikko P. K. , Paterno Jussi J. , Kivinen Niko , Siintamo Leea , Koskela Ali K. J. , Kaarniranta Kai 
Published: October 2021

ABSTRACTPurposeIt has been hypothesized that epithelial–mesenchymal transition (EMT) may occur in the retinal pigment epithelium of advanced stage age‐related macular degeneration (AMD). Various serum and plasma growth factors and inflammatory mediators have been linked to AMD. We were interested in finding out whether systemic levels of EMT‐associated markers were altered in the serum of wet AMD patients. Serum biomarkers associated with the various pathological processes of AMD may present an avenue towards identifying and characterizing the birth mechanisms of wet AMD, its progression and severity, paving the way towards the application of precision medicine.MethodsWe chose to measure the serum levels of known biomarkers of EMT – EGF (epidermal growth factor), ET‐1 (endothelin 1), IL‐8 (interleukin 8), TGF‐β1 and TGF‐β2 (transforming growth factor‐beta 1 and 2) and VEGF‐A (vascular endothelial growth factor A) – using enzyme‐linked immunosorbent assays. We measured them from 71 Finnish wet AMD patients who were receiving intravitreal anti‐VEGF‐A injection treatments, as well as 64 age‐adjusted controls.ResultsWe found significantly elevated levels of ET‐1, IL‐8 and TGF‐β2 in the serums of wet AMD patients.ConclusionsET‐1, IL‐8 and TGF‐β2 appear to be useful serum biomarkers in understanding active wet AMD. However, we cannot conclude that local retinal EMT‐processes could be observed from the corresponding systemic serum biomarkers in patients undergoing anti‐VEGF‐A treatments.
Approaches towards tissue‐selective pharmacology of the mineralocorticoid receptor
Authors: Clarisse Dorien , Deng Lisa , de Bosscher Karolien , Lother Achim 
Published: October 2021

Mineralocorticoid receptor antagonists (MRAs) are highly effective therapies for cardiovascular and renal disease. However, the widespread clinical use of currently available MRAs in cardiorenal medicine is hampered by an increased risk of hyperkalaemia. The mineralocorticoid receptor (MR) is a nuclear receptor responsible for fluid and electrolyte homeostasis in epithelial tissues, whereas pathophysiological MR activation in nonepithelial tissues leads to undesirable pro‐inflammatory and profibrotic effects. Therefore, new strategies that selectively target the deleterious effects of the MR but spare its physiological function are needed. In this review, we discuss recent pharmacological developments starting from novel non‐steroidal MRAs, such as finerenone or esaxerenone, that are now entering clinical use, to concepts arising from the current knowledge of the MR signalling pathway, aiming at receptor–coregulator interaction, epigenetics or downstream effectors of the MR.LINKED ARTICLESThis article is part of a themed issue on Emerging Fields for Therapeutic Targeting of the Aldosterone‐Mineralocorticoid Receptor Signaling Pathway. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.13/issuetoc
Sedimentary architecture of a Late Cretaceous under‐filled rift basin, Canterbury Basin, New Zealand
Authors: Barrier Andrea , Browne G. H. , Nicol A. , Bassett Kari 
Published: October 2021

AbstractThe Canterbury Basin in southeastern Zealandia was initiated during the late Albian (ca. 105 Ma) as a rift system, prior to the onset of seafloor spreading between Zealandia and eastern Gondwana at ca. 85 Ma. Basin‐fill architecture and sediment types have been determined from interpretation of 2D and 3D seismic‐reflection lines tied to five wells and compared to outcrop data from the literature. These data show that Cretaceous syn‐rift basin‐fill architecture was controlled by normal faulting, which produced basin and range topography that persisted for more that ca. 30 Myr after the cessation of faulting. Initial sedimentation was dominated by short drainage systems sourced from within the basin to produce alluvial fans along fault scarps, which inter‐fingered with axial‐flowing braided river conglomerates, coal measures and mudstone‐rich lake deposits in more central portions of the basins. Marine incursion of the basin from the east commenced during rifting and onset of Gondwana breakup, with maximum water depths achieved in the Oligocene. Post‐rifting, detrital sediments were mainly sourced locally from structural highs and augmented by pelagic sedimentation, which collectively draped and eventually buried most of the earlier‐formed horsts by the Early Eocene. The temporal persistence of basin and range topography reflected the low rates of erosion of horst blocks compared to the rates of fault displacement. The lack of substantial sediment input from outside of the rift basin was a key factor in the under‐filling of the Canterbury Basin. This research emphasises the key role played by sediment supply in rift basin filling. Despite an abundance of active faulting at initiation, some rift basins may fill slowly over tens of million years after rift cessation.