bluuebunny/crossref_metadata_2025_split huggingface dataset:
Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs
Authors: Vegas Cómitre Maria D. , Cortellini Stefano , Cherlet Marc , Devreese Mathias , Roques Beatrice B. , Bousquet-Melou Alain , Toutain Pierre-Louis , Pelligand Ludovic 
Published: November 2021

Background: Data regarding antimicrobial pharmacokinetics (PK) in critically ill dogs are lacking and likely differ from those of healthy dogs. The aim of this work is to describe a population PK model for intravenous (IV) amoxicillin–clavulanic acid (AMC) in both healthy and sick dogs and to simulate a range of clinical dosing scenarios to compute PK/PD cutoffs for both populations.Methods: This study used a prospective clinical trial in normal and critically ill dogs. Twelve client-owned dogs hospitalized in the intensive care unit (ICU) received IV AMC 20 mg/kg every 8 h (0.5-h infusion) during at least 48 h. Eight blood samples were collected at predetermined times, including four trough samples before the next administration. Clinical covariates and outcome were recorded, including survival to discharge and bacteriologic clinical failure. Satellite PK data were obtained de novo from a group of 12 healthy research dogs that were dosed with a single AMC 20 mg/kg IV. Non-linear mixed-effects model was used to estimate the PK parameters (and the effect of health upon them) together with variability within and between subjects. Monte Carlo simulations were performed with seven dosage regimens (standard and increased doses). The correlation between model-derived drug exposure and clinical covariates was tested with Spearman's non-parametric correlation analysis. Outcome was recorded including survival to discharge and bacteriologic clinical failure.Results: A total of 218 amoxicillin concentrations in plasma were available for healthy and sick dogs. A tricompartmental model best described the data. Amoxicillin clearance was reduced by 56% in sick dogs (0.147 L/kg/h) compared with healthy dogs (0.336 L/kg/h); intercompartmental clearance was also decreased (p &lt;0.01). None of the clinical data covariates were significantly correlated with individual exposure. Monte Carlo simulations showed that higher PK/PD cutoff values of 8 mg/L could be reached in sick dogs by extending the infusion to 3 h or doubling the dose.Conclusions: The PK of AMC is profoundly different in critically ill dogs compared with normal dogs, with much higher interindividual variability and a lower systemic clearance. Our study allows to generate hypotheses with regard to higher AMC exposure in clinical dogs and provides supporting data to revise current AMC clinical breakpoint for IV administration.
Practical and theoretical aspects of determining the sulfite-binding capability of white table wines
Authors: Тимофеев Р.Г. , Вьюгина М.А. 
Published: November 2021

Работа посвящена совершенствованию методологических основ оценки сульфитосвязывающей способности сухих белых столовых вин. Предложена и экспериментально подтверждена математическая модель связывания сернистой кислоты компонентами вина. Разработана оригинальная методика оценки сульфитосвязывающей способности белых столовых вин и методология ее применения для технологических расчетов при сульфитации вин.
The work is concerned with improving the methodological basis for assessing the sulfite-binding capability of dry white table wines. A mathematical model of binding the sulfurous acid by wine components has been proposed and experimentally confirmed. An original method for assessing the sulfite-binding capability of white table wines and a methodology of its application for technological calculations in the process of wine sulfiting has been developed.
Intervensi Gaya Hidup Terhadap Pencegahan Diabetes Melitus Tipe 2 Pada Pasien Pra Diabetes
Authors: Fitriani Fitriani , Sanghati Sanghati 
Published: November 2021

Pendahuluan: Pra diabetes merupakan kondisi dimana kadar glukosa darah berada di atas normal, namun belum memenuhi standar untuk didiagnosis sebagai diabetes. Literature review ini bertujuan untuk mengetahui efektifitas intervensi gaya hidup dalam mencegah risiko terjadinya DM tipe 2 pada pasien pra diabetes. Metode: Pencarian artikel menggunakan lima database yaitu Pubmed, Proquest, ScienceDirect, Cochrane Librarydan Google Scholar teridentifikasi 21.380 artikel. Hasil: Lima studi memenuhi kriteria menunjukkan bahwa intervensi gaya hidup efektif mencegah risiko terjadinya DM tipe 2 pada pasien pra diabetes. Empat studi melaporkan tidak ada peserta mengembangkan DM tipe 2 dan hanya satu studi yang melaporkan perkembangan pra diabetes menjadi DM tipe 2, namun secara keseluruhan lebih besar pada kelompok kontrol dibandingkan perlakuan (22,8% vs 15,0%). Pada usia 18-64 tahun, intervensi gaya hidup dapat mengurangi risiko diabetes dalam dua tahun hingga 30%, pada tahun-tahun berikutnya 40% dan 10%. Sedangkan pada usia 65-84 tahun dari 40% menjadi 50% dalam dua tahun pertama dan dari 10% menjadi 20% pada tahun-tahun berikutnya. Kesimpulan: Berdasarkan hasil review lima artikel disimpulkan bahwa intervensi gaya hidup efektif dapat mencegah risiko perkembangan DM tipe 2 pada penderita pra diabetes
Anemia Ferropenica Severa secundaria a Uncinarias
Authors: Uscategui Ruiz Adriana Catalina , Mora Buitrago Heison Joaquin , Castillo Mejia Milena del Pilar 
Published: November 2021

duodenale, se dio manejo con albedazol 400 mg, además de suplemento con sulfato ferroso.
La infección por uncinarias es causada por los helmintos Necator americanus y Ancylostoma duodenale es transmitida a través del contacto con suelo contaminado, y uno de sus mayores compromisos es la anemia ferropenica, por perdidas gastrointestinales que resulta de la ruptura de capilares y ateriolas en unión del gusano a la pared intestinal
Problems of application of the provisions of the law on the prohibition of withdrawal of assets of public pension funds located in liquidated banks
Authors: Oliinyk Oleh 
Published: November 2021

The article analyzes the current legislation of Ukraine on private pension funds provision and liquidation of banks. In particular,the inability of a private pension fund to be the owner of pension assets, which are accumulated in it, identified and described by thestatutory guarantees of preservation of pension assets, is analyzed and substantiated. The practice of application of the specified provisionsof the law by courts is analyzed. The problem of practical application of the guarantees of preservation of pension assets definedby the law is revealed and the general ways of the decision of this problem are offered.Today Ukraine is preparing for the practical introduction of the second level of the pension system – mandatory pension accumulation,which should ensure the long-term accumulation, investment and safekeeping of pension assets of future retirees. Thus thereliability of the functioning of all levels of the pension system of Ukraine requires reliable long-term storage of pension assets. In particular,there is the issue of protecting the safety of pension assets during the bankruptcy of custodian banks of pension assets.The current legislation of Ukraine contains norms that guarantee the preservation of pension assets. But in practice there arewidespread cases of non-return of pension assets to private pension funds from liquidated banks. Therefore, there is an urgent need toidentify the source of this problem and suggest ways to solve it.
Ukrainian legislation needs to be improved in terms of establishing a clear legal mechanism and normatively setting deadlinesfor the Fund to return deposits of individuals to private pension funds of pension assets owned by insured individuals participating insuch funds, and accumulated and accounted for in such funds.
DIGITALISASI MANAJEMEN SISTEM DOKUMEN PENGELOLAAN PERPUSTAKAAN MENGGUNAKAN QR CODE DAN DIGITAL SIGNATURE
Authors: Muhammad Fabio Armandani  , Dedi Mulyadi  
Published: November 2021

Digitalisasi dokumen merupakan suatu langkah dalam kemampuan serta optimalisasi tempat penyimpanan dan keamanan, pengisian, pencetakan, perekapan data – data sehingga mengurangi penggunaan dokumen hardcopy dan legalitas dokumen tetap utuh. Namun, pada Universitas Singaperbangsa Karawang masih terjadi masalah kehilangan atau perusakan data Mahasiwa yang diakibatkan belum optimalnya sistem digitalisasi dokumen sehingga masih banyak data yang belum tervalidasi. Alasan ini dibuat untuk dapat membuktikan validasi digitalisasi dokumen dengan menerapkan QR Code dan Digital Signature. Adapun rancangan penelitian ini menggunakan metode SDLC model Prototype. tahapan penelitian ini dibagi menjadi enam, yaitu pemilihan logika kode Hash, aplikasi berbasis web, pembuatan private key dan public key, pengembangan antarmuka aplikasi berbasis mobile, integrasi fungsi yang dibuat dengan aplikasi web, dan integrasi fungsi yang dibuat dengan aplikasi mobile. Hasil penelitian ini diharapkan bisa digunakan dalam pengelolaan sebuah dokumen dalam bentuk fisik ke dalam bentuk digital dengan menggunakan QR code.
Kata kunci — digitalisasi dokumen, QR code, dan digital signature
PENGARUH LIKUIDITAS DAN SOLVABILITAS TERHADAP KEPUTUSAN LINDUNG NILAI
Authors: Wildan Army Abdillah  , Maya Sari  
Published: November 2021

Penelitian ini bertujuan untuk mengetahui pengaruh likuitas, solvabilitas terhadap keputusan lindung nilai pada perusahaan pertambangan di Bursa Efek Indonesia periode 2016-2019 dengan menggunakan regresi logistik biner. Jumlah populasi dalam penelitian ini adalah 41 perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia periode 2016-2019. Jenis data yang digunakan adalah data sekunder yang diperoleh dari Bursa Efek Indonesia. Hasil pengujian signifikan secara simultan terdapat pengaruh likuidtas dan solvabilitas terhadap keputusan lindung nilai, sedangkan secara parsial variabel likuiditas berpengaruh signifikan sementara solvabilitas tidak berpengaruh signifikan terhadap keputusan lindung nilai.
Kata kunci: keputusan lindung nilai, likuiditas, dan solvabilitas
HUBUNGAN TAYANGAN KARTUN UPIN DAN IPIN DENGAN EFIKASI DIRI SISWA SEKOLAH DASAR
Authors: Yayan Alpian  , Sri Wulan Anggraeni  , Nurul Khifriyani  
Published: November 2021

Masalah yang terjadi di ruang lingkung pendidikan dasar menunjukkan bahwa siswa memiliki efikasi diri yang rendah, hal ini terjadi ketika dalam menyelesaikan tugas, siswa mudah menyerah dan merasa sulit dalam mengerjakan soal yang sukar dan banyak, siswa tidak gigih dalam belajar dan tidak serius dalam menyimak materi. Selain itu, inisiatif siswa juga masih rendah, dan masih bergantung pada instruksi guru. Penelitian ini bertujuan untuk mengetahui hubungan tayangan kartun upin dan ipin dengan efikasi diri siswa kelas VI SDN Gugus Asri (Adiarsa Barat – Nagasari) Kecamatan Karawang Barat. Penelitian ini merupakan jenis penelitian kuantitatif. Hasil pengujian hipotesis, terdapat hubungan antara tayangan kartun upin dan ipin dengan efikasi diri siswa. Hal ini diperoleh thitung 3,152 > ttabel 1,986 dan r_xy 0,317 dengan signifikan 0,05 dan n = 96 menunjukkan bahwa hipoesis diterima. Dari hasil penelitian ini dapat disimpulkan bahwa tayangan kartun upin dan ipin dengan efikasi diri siswa memiliki hubungan yang rendah.
Kata kunci: kartun upin dan ipin, efikasi diri siswa.

Problems that occur in the basic education environment show that students have low self-efficacy, this occurs when completing assignments, students easily give up and find it difficult to work on difficult and many questions, students are not persistent in learning and are not serious in listening to material. In addition, student initiative is still low, and still depends on teacher instructions. This study aims to determine the relationship between upin and ipin cartoon shows with self-efficacy of grade VI SDN Gugus Asri (Adiarsa Barat - Nagasari) West Karawang District. This research is a type of quantitative research. The results of hypothesis testing, there is a relationship between Upin and IPIN cartoon shows with student self-efficacy. It is obtained that tcount 3.152> t table 1.986 and r_xy 0.317 with a significant 0.05 and n = 96 indicating that hypoesis is accepted. From the results of this study it can be concluded that upin and ipin cartoon shows with student self-efficacy have a low relationship.
Keywords: upin and ipin cartoon, student self-efficacy
Алгоритъм за диагностика на болест на Stargardt и cone-rod дистрофии
Authors: Мермеклиева Елена 
Published: November 2021

Цел: Да представим алгоритъм, включващ задълбочени клинични, електрофизиологични и генетични изследвания, благодарение на който е поставена правилна диагноза на пациенти с болест на Stargardt и cone-rod дистрофии.
Материал и методи: Представяме двама пациенти, на които са извършени пълен офталмологичен преглед, оптична кохерентна томография, фундусова автофлуоресценция и/или флуоресцеинова ангиография, компютърна периметрия и фулфилд и мултифокална електроретинография, чрез които е поставена клиничната диагноза, потвърдена и генетично.
Резултати: Част от симптоматиката на пациентите с cone-rod дистрофия, както и някои от клиничните изследвания биха могли погрешно да се интерпретират като болест на Stargardt, но след задълбочени електрофизиологични изследвания, които показват намалена дифузна електрофизиологична активност на конусчетата и в по-малка степен на пръчиците, се налага ревизия на първоначалната клинична диагноза, потвърдена по-късно и генетично.
Заключение: Задълбоченото клинично, електрофизиологично и генетично изследване на пациентите с наследствени ретинални дистрофии е от съществено значение за правилната диагноза и избора на терапевтично поведение. Представеният алгоритъм е полезен за диференциално-диагностичното разграничаване на различните видове наследствени ретинални дистрофии, което в някои случаи е много трудно и изисква диференциран подход.
Parliamentary control in the spheres of spirituality and culture: security aspec
Authors: KORZH I. 
Published: November 2021

This article examines the issue of the effectiveness and quality of the implementation of parliamentary control in the spheres of spirituality and culture, as an aspect of ensuring national security in the modern conditions of the hybrid aggression of the Russian Federation against Ukraine. It is noted that parliamentary control in Ukraine is extremely insufficient and rather contradictory, which does not yet allow to talk about the stability of parliamentary control as such, about its proper scientific understanding and legal consolidation in modern conditions, especially in the context of the hybrid aggression of the Russian Federation against Ukraine. It was stated that social changes caused by globalization processes affect the state of ensuring national security in such spheres as culture and spirituality. Currently, this issue has not been studied enough, and therefore needs further development. It was noted that in the field of culture, certain positive changes in the implementation of state (parliamentary) control have been achieved in recent years. However, in the sphere of spirituality (spiritual culture) and in the related religious sphere, as a result of the ideological sabotage and special informational operations carried out by the Russian Federation, a spiritual crisis has actually been generated in Ukraine, the resolution of which is an urgent task of the state power. Parliamentary control in these areas, which should be carried out through the prism of national security, is virtually absent. A number of proposals have been worked out, which are advisable to be introduced into the process of exercising parliamentary control over the aforementioned spheres.
The best practices of foreign experience of counterfeiting and disinformation
Authors: МАLIARENKO V. 
Published: November 2021

The concepts and types of fakes are considered. The principles and methods of detecting fakes and misinformation on the examples of EU countries are determined. The experience of some EU countries in the field of counterfeiting and misinformation is analyzed. The practice of some countries of the world to criminalize the dissemination of unreliable information and fakes is summarized. Measures to combat fakes and misinformation are proposed. The directions of the improvements of countering fakes in the domestic media space have been identified.
Threatening trends in the use of bot pharms to the detrimation of the state interests of Ukraine: prevention and control mechanisms
Authors: YUSHKOV A. 
Published: November 2021

The concepts and types of bots are considered. The signs and spheres of activity of bot farms are determined. The algorithm for creating and distributing fake pages is outlined. Procedures for responding to the dissemination of false and unreliable information within the current legislation of Ukraine are detailed. The achievements of the domestic special services in the direction of counteracting the illegal activities of bot farms, which are coordinated by curators from the Russian Federation, are highlighted. The task of pro-Russian bot farms in Ukraine is generalized. The principles of the state policy of combating fakes and propaganda on social networks are determined. The directions of improvements of the organizational and legal framework for the systematic counteraction to the functioning of crime bot farms as a threat to the state interests of Ukraine are specified.
Nuclear Physics Multimessenger Astrophysics Constraints on the Neutron Star Equation of State: Adding NICER’s PSR J0740+6620 Measurement
Authors: Pang Peter T. H. , Tews Ingo , Coughlin Michael W. , Bulla Mattia , Van Den Broeck Chris , Dietrich Tim 
Published: November 2021

Abstract
In the past few years, new observations of neutron stars (NSs) and NS mergers have provided a wealth of data that allow one to constrain the equation of state (EOS) of nuclear matter at densities above nuclear saturation density. However, most observations were based on NSs with masses of about 1.4 M
⊙, probing densities up to ∼three to four times the nuclear saturation density. Even higher densities are probed inside massive NSs such as PSR J0740+6620. Very recently, new radio observations provided an update to the mass estimate for PSR J0740+6620, and X-ray observations by the NICER and XMM telescopes constrained its radius. Based on these new measurements, we revisit our previous nuclear physics multimessenger astrophysics constraints and derive updated constraints on the EOS describing the NS interior. By combining astrophysical observations of two radio pulsars, two NICER measurements, the two gravitational-wave detections GW170817 and GW190425, detailed modeling of the kilonova AT 2017gfo, and the gamma-ray burst GRB 170817A, we are able to estimate the radius of a typical 1.4 M
⊙ NS to be

11.94

−
0.87

+
0.76

km

at 90% confidence. Our analysis allows us to revisit the upper bound on the maximum mass of NSs and disfavors the presence of a strong first-order phase transition from nuclear matter to exotic forms of matter, such as quark matter, inside NSs.
Cooling-induced Vortex Decay in Keplerian Disks
Authors: Fung Jeffrey , Ono Tomohiro 
Published: November 2021

Abstract
Vortices are readily produced by hydrodynamical instabilities, such as the Rossby wave instability, in protoplanetary disks. However, large-scale asymmetries indicative of dust-trapping vortices are uncommon in submillimeter continuum observations. One possible explanation is that vortices have short lifetimes. In this paper, we explore how radiative cooling can lead to vortex decay. Elliptical vortices in Keplerian disks go through adiabatic heating and cooling cycles. Radiative cooling modifies these cycles and generates baroclinicity that changes the potential vorticity of the vortex. We show that the net effect is typically a spin down, or decay, of the vortex for a subadiabatic radial stratification. We perform a series of two-dimensional shearing box simulations, varying the gas cooling (or relaxation) time, t
cool, and initial vortex strength. We measure the vortex decay half-life, t
half, and find that it can be roughly predicted by the timescale ratio t
cool/t
turn, where t
turn is the vortex turnaround time. Decay is slow in both the isothermal (t
cool ≪ t
turn) and adiabatic (t
cool ≫ t
turn) limits; it is fastest when t
cool ∼ 0.1 t
turn, where t
half is as short as ∼300 orbits. At tens of astronomical units where disk rings are typically found, t
turn is likely much longer than t
cool, potentially placing vortices in the fast decay regime.
Black Hole Gravitational Potential Enhanced Fallback Accretion onto the Nascent Lighter Compact Object: Tentative Evidence in the O3 Run Data of LIGO/Virgo
Authors: Tang Shao-Peng , Li Yin-Jie , Wang Yuan-Zhu , Fan Yi-Zhong , Wei Da-Ming 
Published: November 2021

Abstract
In a binary system, the gravitational potential of the primary black hole may play an important role in enhancing the fallback accretion onto the lighter compact object newly formed in the second supernova explosion. As a result, the final masses of the binary compact objects would be correlated, as suggested recently by Safarzadeh & Wysocki. In this work, we analyze the mass distribution of four gravitational-wave events, which are characterized by both a small mass ratio and a low mass (≤5M
⊙) of the light component, and find tentative evidence for a mass correlation among the objects. To evaluate the feasibility of testing such a hypothesis with upcoming observations, we carry out simulations with a mock population and perform Bayesian hierarchical inference for the mass distribution. We find that with dozens of low mass ratio events, whether there exists correlation in the component mass distributions or not can be robustly tested and the correlation, if it exists, can be well determined.
A Comparison of Surface and Total Deltamethrin Levels of Insecticide-Treated Nets and Estimation of the Effective Insecticidal Lifetime
Authors: Green Michael , Maxyay Mayfong , Pongvongsa Tiengkham , Phompida Samlane , Swamidoss Isabel , Smith Stephen , Irish Seth , Newton Paul 
Published: November 2021

ABSTRACT.
The ability to anticipate the useful lifetime of an insecticide-treated mosquito net (ITN) would provide a proactive approach for planning net distribution programs. Therefore, we used an exponential decay model of deltamethrin depletion to predict the effective insecticidal lifetime of PermaNet® 2.0 nets used in the Lao PDR. Residual deltamethrin was measured using two nondestructive analytical field methods; X-ray fluorescence (total levels) and a colorimetric field test (surface levels) at 12 and 24 months postdistribution. The model assumes that the 12-month depletion rate can be used to predict future levels. The median total and surface deltamethrin levels for the Lao nets at 12 months were 31.2 and 0.0743 mg/m2, respectively. By defining a failed net as having total deltamethrin levels of less than 15 mg/m2 or a surface level less than 0.0028 mg/m2, it was predicted that 50% of the group of nets will fail at about 27 months after distribution.