bluuebunny/crossref_metadata_2025_split huggingface dataset:
Position specific physical performance and running intensity fluctuations in elite women’s football
Authors: Winther A. K. , Baptista I. , Pedersen S. , Randers M. B. , Johansen D. , Krustrup P. , Pettersen S. A. 
Published: November 2021

AbstractThe purpose of the present study was to investigate the physical performance of elite female football players during match play along with transient alterations in running performance following 1‐ and 5‐min univariate peak periods. 54 elite female players from four top‐level Norwegian teams were monitored for one season (n = 393 match observations), and physical performance data collected using STATSport GPS APEX. Results revealed significant differences in physical performance between the positions during full match play, particularly between wide and central players. Both full backs (FBs) and wide midfielders (WMs) covered more total distance (TD), high‐speed running distance (HSRD), and sprint distance (SpD) than center backs (CBs) (p < 0.05–0.001), while WMs also covered more HSRD than both central midfielders (CMs) (p < 0.01) and forwards (FWs) (p < 0.05), and more acceleration ‐and deceleration distance (Accdist and Decdist) than both CBs and CMs (p < 0.01–0.001). A similar pattern was observed for the peak period analysis, with FBs and WMs covering more SpD in peak 1 min than CBs and CM (p < 0.001) and more SpD in peak 5‐min than CBs, CMs, and FWs (p < 0.001). Irrespective of the variable analyzed, greater distances were covered during the peak 5‐min period than in the next‐5 and mean 5‐min periods (p < 0.001). Significant (p < 0.001), but small to trivial (Cohen's Dz: 0.07–0.20), decreases in distance covered were also observed for each variable following each univariate peak 5‐min period. In conclusion, practitioners should account for differences in physical performance when developing training programs for female football players and be aware of transient reductions in physical performance following univariate peak 1‐ and 5‐min periods. Specifically, the very high intensity in 1‐min peak periods adds support to the principal of executing speed endurance activities during training to mirror and be prepared for the physical demands of match play.
Preverbal Subjects with a Partitive Article: A Comparison Between Aosta Valley Francoprovençal and French*
Authors: Ihsane Tabea 
Published: November 2021

AbstractIn this paper, we focus on two constructions that allow preverbal subjects headed by a so‐called partitive article in French, that is, sentences with a stage‐level predicate and generic emphatic constructions. The aim is to explain why their counterparts were generally not accepted by speakers of Francoprovençal, an endangered and understudied Gallo‐Romance language, in a translation task carried out in fieldwork in the Aosta Valley in Italy (Ihsane 2018, Stark & Gerards 2020). To account for our results, we propose that preverbal subjects in the two languages have different statuses and develop the typology of languages postulated by Dobrovie‐Sorin & Laca (2003): we argue that there are more than two types of languages when it comes to the status of preverbal subjects and that Francoprovençal differs not only from French (Ihsane 2018), but also from languages like Spanish: it generally has topical subjects like Spanish but also allows some subjects that represent new information to occur preverbally. In contrast to French, however, this option is restricted to nominals that reach a certain degree of referential givenness (Gundel 2003).
Risk factors and outcomes of BK viremia among deceased donor kidney transplant recipients based on donor characteristics
Authors: Breyer Isabel , Dodin Ban , Djamali Arjang , Jorgenson Margaret R. , Garg Neetika , Aziz Fahad , Mohamed Maha A. , Mandelbrot Didier A. , Parajuli Sandesh 
Published: November 2021

AbstractIntroductionBK polyomavirus (BKV) is a common infection among kidney transplant recipients (KTR). Risk factors and outcomes based on donor characteristics remain largely unknown.MethodsIn this study, we aimed to analyze the impact of donor factors through a paired kidney analysis. We included 289 pairs of adult deceased donor transplants (578 KTRs total); each pair had received kidneys from the same donor. Recipient pairs were divided into three groups: “no BK group” if neither KTR developed BK viremia (n = 336), “discordant” if the only one did (n = 176), and “concordant” if both did (n = 66). Acute rejection (AR), graft failure, and BK nephropathy (BKN) were outcomes of interest.ResultsDonors in the concordant group were younger, had lower kidney donor profile index (KDPI), and were less likely to be donor after circulatory death (DCD). In multivariate analyses, KTRs who had a donor with a higher body mass index (BMI) (hazard ratio (HR): 0.97; 95% confidence interval (CI): 0.95–0.99; p = .009) were less likely to develop BKV. Concordance was not associated with AR (HR: 0.83; 95% CI: 0.51–1.34; p = .45), graft failure (HR: 1.77; 95% CI: 0.42–7.50; p = .43), or BKN (HR: 1.02; 95% CI: 0.51–2.03; p = .96).DiscussionOur study suggests lower donor BMI is associated with BKV infection, and concordance or discordance between paired kidney recipients is not associated with poor outcomes.
Viral safety of recovered plasma for contract fractionation; an Iranian experience, 2006–2015
Authors: Amini‐Kafiabad Sedigheh , Pourfatollah Ali Akbar 
Published: November 2021

AbstractObjectiveThe current study analysed the viral safety among Iranian blood donors.BackgroundPlasma products demand is increasing in the world. With contract plasma fractionation, the plasma wastage decreases and the access of patients to plasma‐derived medicines (PDM) improves.Study and Design MethodScreening results including hepatitis B surface antigen (HBsAg), anti‐hepatitis C virus (HCV), and human immunodeficiency virus (HIV) Ag/Ab of 19 054 036 donations from 2006 to 2015 were analysed. The plasma for fractionation was tested for HBV DNA, HCV RNA, HIV RNA, HAV RNA, and Parvovirus B19 DNA by fractionators. New samples were collected from the positive donors and retested. The prevalence of serological and nucleic acid testing (NAT) markers per 105 donations, 95% confidential interval (CI), and p‐values were calculated.ResultsThe prevalence of markers was as follows: 250/105 donations for HBsAg from 516 in 2006 to 116/105 donations in 2015; 74/105 donations for HCV, decreasing from 127 to 41/105 and 3.6/105 for HIV during current study. During 10 years, 5 713 641 units of recovered plasma were shipped for contract fractionation to produce PDM; 0.26/105 donations for HBV DNA and 0.14/105 for HCV RNA were reported positive. The results of five retested samples for HBV and one sample for HCV were negative.ConclusionThe prevalence of HBV, HCV, and HIV in blood donations was extremely low. Thanks to the availability, high quality and safety of recovered plasma as a result of the improvements in the quality system at IBTO, this plasma could be used for the production of PDMPs.
Therapeutic apheresis and non‐blood donor related apheresis current practices at various blood centres of healthcare organisations of India: A brief online survey
Authors: Kumawat Vijay , Tripathi Parmatma Prasad , Patidar Gopal Kumar 
Published: November 2021

AbstractObjectivesTo determine the variability in therapeutic apheresis (TA) and non‐blood donor related apheresis practices, and the extent of expertise and knowledge of blood centre staff.BackgroundApheresis activity that was earlier limited to therapeutic plasma exchange (TPE) and donor apheresis at few centres in India has seen remarkable surge involving many centres practising TA and non‐blood donor related apheresis. The decentralised transfusion medicine practice in country has resulted in wide variability of knowledge and practice of TA. An online survey was conducted to achieve study objectives.Study design and methodsA 22 questionnaire survey was sent to the 215 blood centres through e‐mail link focussing on three aspects; basic information of the participating centres, details of TA procedures and education and training levels of the staff.ResultsMajority (71.9%) of centres were teaching institutions among analysed 57 centres. TPE (85.9%) and therapeutic cytapheresis (71.9%) were the most common TA procedures. The clinical haematology (68.4%) followed by neurology (64.9%) were the specialities utilising TA. The 64.9% centres used continuous flow cell separator and central venous access (52%) was preferred vascular access. A combination of normal saline, fresh frozen plasma and 5% albumin replacement fluid was first choice. Doctors involved in TA were trained in apheresis during their MD/DNB degree, but no structured training program existed for other category of staff.ConclusionThere was a wide variability in TA practice in India and a dedicated training program for all categories of staff was emphasised by majority of participants.
Can we talk about price with patients when choosing antiretroviral therapy? A survey with people living with HIV and prescribers in France
Authors: Papot Emmanuelle , Kalampalikis Nikos , Doumergue Marjolaine , Pilorgé Fabrice , Quatremère Guillemette , Yazdanpanah Yazdan , Préau Marie 
Published: November 2021

ObjectiveThe aim of this study was to evaluate people living with HIV (PLWH) and HIV specialist prescribers’ perception of discussing antiretroviral therapy (ART) price in PLWH’s care and the acceptability of choosing or switching to various types of less expensive ARTs.DesignCross-sectional surveys (one in a convenience sample of PLWH and one in a voluntary response sample of HIV specialist prescribers).Setting and participantsThe surveys were conducted among PLHW attending an HIV clinic in the North of Paris (cohort of 4922 PLWH in 2016), and HIV specialists working in French HIV clinics (210 across 12 districts/28), between January and June 2016.MethodSelf-administered questionnaires were constructed using data collected during focus groups with PLWH and prescribers. Pretests were carried out to select the questions and items. Descriptive analyses of the 129 complete questionnaires of PLWH and 79 of prescribers are presented.ResultsAmong PLWH, 128/129 were on ART and 54% (69/128) gave a fair estimation of the price of their current regimen. Among prescribers, 24% (19/79) thought that their patients knew this price. Taking into account the price of ART was not perceived as a negative step in the history of French response to HIV epidemic for 53% (68/129) of PLWH and 82% (65/79) of prescribers. Seventy-seven PLWH (60%) would agree to switch to less expensive antiretroviral regimens (as effective and with similar adverse events) if pills were bigger; 42 (33%) if there were more daily doses, and 37 (29%) if there were more pills per dose; prescribers were more circumspect.ConclusionA high proportion of PLWH gave a fair estimate of their ART price and this seemed unexpected by HIV specialists. Consideration of drug prices when choosing ART was perceived as conceivable by PLWH and prescribers if effectiveness and tolerance were also considered.
Therapy-dependent inconsistencies in self-reported use of complementary and alternative medicine in the general population: findings from a longitudinal study
Authors: Jensen Heidi Amalie Rosendahl , Ekholm Ola 
Published: November 2021

ObjectiveInformation on the use of complementary and alternative medicine (CAM) in the general population is often collected by means of surveys, causing the reliability of data to rely on the memory accuracy of the respondent. The objective of this study was to examine the consistency in self-reported CAM use using data from two survey waves 4 years apart.DesignLongitudinal study.Setting/participantsData were obtained from the Danish Health and Morbidity Surveys. A nationally representative subsample of the individuals invited in 2013 was reinvited in 2017. In all, 2297 individuals (≥16 years) completed the self-administered questionnaire in both waves, including questions on for example, CAM use.Main outcome measuresThe use of six different CAM therapies (acupuncture; craniosacral therapy; faith healing and/or clairvoyance; nutritional counselling; massage; osteopathy or other manipulative therapies; reflexology) was assessed by the response categories ‘Yes, within the past 12 months’, ‘Yes, but previously than within the past 12 months’ and ‘No’. For each CAM therapy, an inconsistent response was defined as either the response combination (1) ‘Yes, within the past 12 months’ in 2013 and ‘No’ in 2017, or (2) ‘Yes, within the past 12 months’ or ‘Yes, but previously than within the past 12 months’ in 2013 and ‘No’ in 2017.ResultsThe inconsistency percentages varied across CAM therapies. The highest levels of inconsistency for CAM use within the past 12 months were observed for nutritional counselling (64.9 %) and faith healing and/or clairvoyance (36.4 %). The lowest proportion of inconsistent responses was observed for acupuncture (18.3%). Overall, the same pattern was observed for lifetime CAM use.ConclusionsThe results highlight the difficulty in obtaining reliable prevalence estimates on the use of CAM in the general population. Future studies should take these findings into account when interpreting similar analyses.
Mobile Health Biometrics to Enhance Exercise and Physical ActivityAdherence inType2 Diabetes (MOTIVATE-T2D): protocol for a feasibility randomised controlled trial
Authors: Hesketh Katie , Low Jonathan , Andrews Robert , Jones Charlotte A , Jones Helen , Jung Mary E , Little Jonathan , Mateus Ceu , Pulsford Richard , Singer Joel , Sprung Victoria S , McManus Alison M , Cocks Matthew 
Published: November 2021

IntroductionExercise and physical activity (PA) are fundamental to the treatment of type 2 diabetes. Current exercise and PA strategies for newly diagnosed individuals with type 2 diabetes are either clinically effective but unsuitable in routine practice (supervised exercise) or suitable in routine practice but clinically ineffective (PA advice). Mobile health (mHealth) technologies, offering biometric data to patients and healthcare professionals, may bridge the gap between supervised exercise and PA advice, enabling patients to engage in regular long-term physically active lifestyles. This feasibility randomised controlled trial (RCT) will evaluate the use of mHealth technology when incorporated into a structured home-based exercise and PA intervention, in those recently diagnosed with type 2 diabetes.Methods and analysisThis feasibility multicentre, parallel group RCT will recruit 120 individuals with type 2 diabetes (diagnosis within 5–24 months, aged 40–75 years) in the UK (n=60) and Canada (n=60). Participants will undertake a 6-month structured exercise and PA intervention and be supported by an exercise specialist (active control). The intervention group will receive additional support from a smartwatch and phone app, providing real-time feedback and enabling improved communication between the exercise specialist and participant. Primary outcomes are recruitment rate, adherence to exercise and loss to follow-up. Secondary outcomes include a qualitative process evaluation and piloting of potential clinical outcome measures for a future RCT.Ethics and disseminationThe trial was approved in the UK by the South East Scotland Research Ethics Committee 01 (20/SS/0101) and in Canada by the Clinical Research Ethics Board of the University of British Columbia (H20-01936), and is being conducted in accordance with the Declaration of Helsinki and Good Clinical Practice. Results will be published in peer-reviewed journals and presented at national and international scientific meetings.Trial registration numbersISRCTN14335124; ClinicalTrials.gov:NCT04653532.
Statin and dual antiplatelet therapy for the prevention of early neurological deterioration and recurrent stroke in branch atheromatous disease: a protocol for a prospective single-arm study using a historical control for comparison
Authors: Huang Yen-Chu , Lee Jiann-Der , Weng Hsu-Huei , Lin Leng-Chieh , Tsai Yuan-Hsiung , Yang Jen-Tsung 
Published: November 2021

IntroductionBranch atheromatous disease (BAD) contributes to small-vessel occlusion in cases of occlusion or stenosis of large calibre penetrating arteries, and it is associated with a higher possibility of early neurological deterioration (END) and recurrent stroke in acute ischaemic stroke. As the pathology of BAD is due to atherosclerosis, we postulate that early intensive medical treatment with dual antiplatelet therapy (DAPT) and high-intensity statins may prevent END and recurrent stroke in acute small subcortical infarction caused by BAD.Methods and analysisIn this prospective, single-centre, open-label, non-randomised, single-arm study using a historical control, we will compare early DAPT and high-intensity statin treatment with a historical control group of patients with BAD who were treated with single antiplatelet therapy without high-intensity statin treatment. Patients will be eligible for enrolment if they are admitted for acute ischaemic stroke within 24 hours, have a National Institutes of Health Stroke Scale (NIHSS) score of 1–8 and are diagnosed with BAD by MRI. Patients will take aspirin, clopidogrel and high-intensity statins (atorvastatin or rosuvastatin) within 24 hours of stroke onset, followed by aspirin or clopidogrel alone from day 22. The primary endpoint is the percentage of patients who develop END within 7 days of stroke onset (defined as an increase in the NIHSS score ≥2 points) and recurrent stroke within 30 days. The total sample sizes will be 138 for the intervention group and 277 for the control group. A historical control group will be drawn from previous prospective observation studies.Ethics and disseminationThe protocol of this study has been approved by the Institutional Review Board of Chang Gung Memorial Hospital (202001386A3). All participants will have to sign and date an informed consent form. The findings arising from this study will be disseminated in peer-reviewed journals and academic conferences.Trial registration numberNCT04824911.
Transforming training into practice with the conflict management framework: a mixed methods study
Authors: Lyons Oscar , Forbat Liz , Menson Esse , Chisholm Julia C , Pryde Kate , Conlin Siobhan , Felton Victoria , Ingle Susanne , McKenzie Celia , Ramachandran Rohana , Sayer Charlotte , Snowball Carly , Strachan-Gadsby Emma , Tisovszky Natasha , Barclay Sarah 
Published: November 2021

ObjectiveTo implement and evaluate the use of the conflict management framework (CMF) in four tertiary UK paediatric services.DesignMixed methods multisite evaluation including prospective pre and post intervention collection of conflict data alongside semistructured interviews.SettingEight inpatient or day care wards across four tertiary UK paediatric services.InterventionsThe two-stage CMF was used in daily huddles to prompt the recognition and management of conflict.ResultsConflicts were recorded for a total of 67 weeks before and 141 weeks after implementation of the CMF across the four sites. 1000 episodes of conflict involving 324 patients/families across the four sites were recorded. After implementation of the CMF, time spent managing episodes of conflict around the care of a patient was decreased by 24% (p<0.001) (from 73 min to 55 min) and the estimated cost of this staff time decreased by 20% (p<0.02) (from £26 to £21 sterling per episode of conflict). This reduction occurred despite conflict episodes after implementation of the CMF having similar severity to those before implementation. Semistructured interviews highlighted the importance of broad multidisciplinary leadership and training to embed a culture of proactive and collaborative conflict management.ConclusionsThe CMF offers an effective adjunct to conflict management training, reducing time spent managing conflict and the associated staff costs.
Cost-effectiveness of domiciliary non-invasive ventilation in patients with chronic obstructive pulmonary disease
Authors: Hall James , Turner Alice Margaret , Dretzke Janine , Moore David , Jowett Sue 
Published: November 2021

BackgroundChronic obstructive pulmonary disease (COPD) is a chronic disease associated with recurring exacerbations, which influence morbidity and mortality for the patient, while placing significant resource burdens on healthcare systems. Non-invasive ventilation (NIV) in a domiciliary setting can help prevent admissions, but the economic evidence to support NIV use is limited.MethodsA Markov model-based cost-utility analysis from the UK National Health Service perspective compared the cost-effectiveness of domiciliary NIV with usual care for two end-stage COPD populations; a stable COPD population commencing treatment with no recent hospital admission; and a posthospital population starting treatment following admission to hospital for an exacerbation. Hospitalisation rates in patients receiving domiciliary NIV compared with usual care were derived from randomised controlled studies in a recent systematic review. Other model parameters were updated with recent evidence.ResultsAt the threshold of £20 000 per quality-adjusted life-year (QALY) domiciliary NIV is 99.9% likely cost-effective in a posthospital population, but unlikely (4%) to be cost-effective in stable populations. The incremental cost-effective ratio (ICER) was £11 318/QALY gained in the posthospital population and £27 380/QALY gained in the stable population. Cost-effectiveness estimates were sensitive to longer-term readmission and mortality risks, and duration of benefit from NIV. Indeed, for stable Global Initiative for Chronic Obstructive Lung Disease (GOLD) for stage 4 patients, or with higher mortality and exacerbation risks, ICERs were close to the £20 000/QALY threshold.ConclusionDomiciliary NIV is likely cost-effective for posthospitalised patients, with uncertainty around the cost-effectiveness of domiciliary NIV in stable patients with COPD on which further research should focus.
Diversity of aquatic insects and biomonitoring of water quality in the upper Ganga River, a Ramsar site: a preliminary assessment
Authors: De Kritish , Sarkar Arkojyoti , Singh Kritika , Uniyal Virendra Prasad , Johnson Jeyaraj Antony , Hussain Syed Ainul 
Published: November 2021

Monitoring of freshwater habitats through aquatic insects is widely used. A study was carried out in March, 2019 at 14 sites in the Upper Ganga River between Brijghat and Narora, a riverine Ramsar site in India, to document the diversity of three major aquatic predatory insect groups—Odonata, Coleoptera, and Hemiptera—and determine their biomonitoring potential. The study recorded three species of Coleoptera, four Hemiptera, 14 dragonflies, and eight damselflies. The Shannon diversity index (H′) ranged from 2.465 to 2.782, Pielou’s Evenness index (J′) from 0.841 to 0.894, and Berger–Parker index of dominance (d) from 0.122 to 0.243. Families Libellulidae (Odonata), Coenagrionidae (Odonata) and Gerridae (Hemiptera) had high relative abundance and dominant status. The stream invertebrate grade number-average level (SIGNAL2) score (for family) ranged from 2.316 to 3.174, lying within quadrant 2 of the SIGNAL2 (family) quadrant diagram. This suggested that the water in the area is likely to have high levels of turbidity, salinity, or nutrients, caused naturally or by anthropogenic activities, and the water has low levels of most toxic chemicals.