bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemanfaatan Seamless Wireless (EoIP) dan GPS pada Sistem Peringatan Perlintasan Kereta Tanpa Palang Pintu
Authors: Pramantha Dio , Indriyanta Gani , Saputra Laurentius Kuncoro Probo 
Published: July 2021

Perlintasan kereta liar tanpa palang pintu dan tanpa penjaga merupakan awal mula sering terjadinya kecelakaan di perlintasan kereta api. Salah satu solusi untuk menyelesaikan permasalahan ini dengan pembangunan sistem otomatis peringatan kedatangan kereta dengan memanfaatkan teknologi seamless wireless Ethernet over Internet Protocol (EoIP). Penelitian ini dilakukan dengan pengujian prototype di lingkungan UKDW dengan panjang pelintasan kurang lebih 70 - 80 meter, menggunakan 1 MCU(Micro Controller Unit) ESP8266 dan 1 GPS Module yaitu node kereta, 2 MCU, 2 unit LCD module, 2 Servo motor dan 2 Buzzer menjadi 2 node perlintasan kereta. Sistem ini diuji coba sebanyak 30 kali dengan checklist pengujian. Pengujian dimulai saat node kereta mengirimkan informasi dalam bentuk longitude dan latitude ke server lalu server akan menghitung jarak antara node kereta dengan setiap node perlintasan kemudian hasil jarak tersebut akan di kirim ke setiap node perlintasan kereta, akan terjadi pengecekan jarak di setiap node perlintasan kereta, pada jarak yang telah ditentukan palang akan ditutup ataupun dibuka. Dari 30 kali percobaan disimpulkan bahwa sistem otomatis peringatan kedatangan kereta dapat mendeteksi kedatangan kereta dan telah berhasil dibangun dengan benar dan berjalan sesuai flow sistem yang sudah dirancangkan. Dilengkapi dengan pemanfaatan Teknologi seamless wireless EoIP yang memungkinkan pembangunan jaringan bahkan di titik buta tidak dapat dijangkau oleh operator seluler ataupun GSM. Oleh karena itu seamless wireless EoIP ini sangat cocok dalam membantu pembangunan sistem peringatan kedatangan kereta api dengan palang otomatis dibuktikan dengan setiap alat dapat terhubung dan tidak terputus selama 30 kali percobaan.
A review of the design and implementation of Ghana's National Water Policy (2007)
Authors: Frimpong Josephine , Adamtey Ronald , Pedersen Anders Branth , Wahaga Esther , Jensen Anne , Obuobie Emmanuel , Ampomah Ben 
Published: July 2021

AbstractAccess to water is a matter of daily survival for people around the world. Water is crucial for human survival and also central to the development of every nation. The recent literature on world water suggests that the water crisis being experienced is related to governance and not a real crisis of scarcity and stress. This paper aims at identifying water governance practices and the challenges associated with water governance in Ghana. The paper reviews the literature on the implementation of policy directives and actions with specific focus on water resources governance aspects of Integrated Water Resources Management (IWRM) in Ghana. Ghana's National Water Policy is expected to turn the fortunes of the country around in terms of water resources management. Concerning water resources management, the policy advocates for an IWRM approach. Since its implementation, certain setbacks have been challenging the effectiveness of the policy, such as inadequate institutional capacity, inadequate funding, ineffective enforcement of existing regulations, inadequate legal framework, and lack of adequate data. The paper suggests, among other things, the building of both human and institutional capacity, and making the environment a government priority, as ways to contribute to the effective implementation of the National Water Policy.
The Plasticity of Circulating Tumor Cells in Ovarian Cancer During Platinum-containing Chemotherapy
Authors: Gening Snezhanna Olegovna , Dolgova Dinara Rishatovna , Abakumova Tatyana Vladimirovna , Antoneeva Inna Ivanovna , Gening Tatyana Petrovna 
Published: July 2021

Background:
Circulating Tumor Cells (CTCs) are a potential source of metastases and
relapses. The data on molecular characteristics of Ovarian Cancer (OC) CTCs are limited.

Objective:
This study aims to assess the TGFβ, CXCL2, VEGFA and ERCC1 expressions in two
OC CTC subpopulations before and during chemotherapy (CT), and their relation to clinical characteristics.

Methods:
Two CTCs subpopulations (EpCAM+CK18+E-cadherin+; EpCAM+CK18+Vimentin+)
were enriched using immunomagnetic separation before treatment and after 3 cycles of platinumcontaining
CT. The expression of mRNA was assessed using RT-qPCR.

Results:
The study included 31 I-IV stage OC patients. During CT, TGFβ levels increased in both
fractions (p=0.054) compared with the initial levels. ERCC1 expression in E-cadherin+ CTCs was
higher during neoadjuvant than adjuvant CT (p=0.004). CXCL2 level in E-cadherin+ CTCs increased
(p=0.038) during neoadjuvant CT compared with the initial. TGF-β expression in vimentin+
CTCs during CT was negatively correlated to disease stage (p=0.003). Principal component
analysis before CT revealed a component combining VEGFA, TGFβ, CXCL2, and a component
with ERCC1 and VEGFA; during CT, component 1 contained ERCC1 and VEGFA, and component
2 - TGFβ and CXCL2 in both fractions. Increased ERCC1 expression in E-cadherin+ CTCs
during CT was associated with decreased Progression-Free Survival (PFS) (HR 1.11 (95% CI
1.03-1.21, p=0.009) in multivariate analysis.

Conclusion:
EpCAM+ OC CTCs are phenotypically heterogeneous, which may reflect variability
in their metastatic potential. CT changes the molecular characteristics of CTCs. Expression of
TGFβ in EpCAM+ CTCs increases during CT. High ERCC1 expression in EpCAM+CK18+E-cadherin+
CTCs during CT is associated with decreased PFS in OC.
Drug-Induced Peripheral Neuropathy: Diagnosis and Management
Authors: Merheb Diala , Dib Georgette , Zerdan Maroun Bou , Nakib Clara El , Alame Saada , Assi Hazem I. 
Published: July 2021

:
Peripheral neuropathy comes in all shapes and forms and is a disorder which is found in
the peripheral nervous system. It can have an acute or chronic onset depending on the multitude of
pathophysiologic mechanisms involving different parts of nerve fibers. A systematic approach is
highly beneficial when it comes to cost-effective diagnosis. More than 30 causes of peripheral neuropathy
exist ranging from systemic and auto-immune diseases, vitamin deficiencies, viral infections,
diabetes, etc. One of the major causes of peripheral neuropathy is drug-induced disease,
which can be split into peripheral neuropathy caused by chemotherapy or by other medications.
This review deals with the latest causes of drug-induced peripheral neuropathy, the population involved,
the findings on physical examination and various workups needed and how to manage each
case.
Network-Based Analysis Reveals Gene Signature in Tip Cells and Stalk Cells
Authors: Li Chen , Xu Lingyun 
Published: July 2021

Background:
Angiogenesis occurs during various physiological or pathological processes such as wound
healing and tumor growth. Differentiation of vascular endothelial cells into tip cells and stalk cells initiates the formation
of new blood vessels. Tip cells and stalk cells are endothelial cells with different biological characteristics and
functions.

Objective:
The aim of this study was to determine the mechanisms of angiogenesis by exploring differences in gene
expression of tip cells and stalk cells.

Methods:
Raw data were retrieved from NCBI Gene Expression Omnibus (GSE19284). Data were reanalyzed using
bioinformatics methods that employ robust statistical methods, including identification of differentially expressed
genes (DEGs) between the stalk and tip cells, Weighted Gene Correlation Network Analysis (WGCNA), gene ontology
and pathway enrichment analysis using DAVID tools, integration of Protein-Protein Interaction (PPI) networks and
screening of hub genes. DEGs of stalk and tip cells were grouped as dataset A. Gene modules associated with differentiation
of stalk and tip cells screened by WGCNA were named dataset B. Further, we retrieved existing markers of
angiogenesis from previous experimental studies on tip and stalk cells which we called dataset C. Intersection of
datasets A, B and C was used as a candidate gene. Subsequently, we verified the results applying Quantitative Polymerase
Chain Reaction (Q-PCR) to our clinical specimen. In general, the Q‐PCR results coincide with the majority of the
expression profile.

Results:
We identified five candidate genes, including ESM1, CXCR4, JAG1, FLT1 and PTK2, and two pathways,
including Rap1 signaling pathway and PI3K-Akt signaling pathway in vascular endothelial cells that differentiate into
tip cells and stalk cells using bioinformatics analysis.

Conclusion:
Bioinformatics approaches provide new avenues for basic research in different fields such as angiogenesis.
The findings of this study provide new perspectives and a basis for the study of molecular mechanisms of vascular
endothelial cell differentiation into stalk and tip cells. Genes and pathways identified in this study are potential biomarkers
and therapeutic targets for angiogenesis in the tumor.
Evaluasi Kualitatif Program Pendidikan dan Pelatihan Calon Kepala Sekolah Model In-On-In
Authors: Andriani Dwi Esti , Juliyanti Dinar Tri , Suyud Suyud , Mustiningsih Mustiningsih , Arifin Arifin 
Published: July 2021

Penelitian ini bertujuan untuk mengevaluasi program penyiapan calon kepala sekolah dengan model in-on-in. Fokus penelitiannya yaitu pada pelaksanaan pendidikan dan pelatihan (diklat) yang terdiri dari tahap in-service learning 1 (ISL1), on the job learning (OJL), dan in-service learning 2 (ISL2). Penelitian menggunakan pendekatan kualitatif. Pengumpulan data dilakukan dengan wawancara semi terstruktur kepada lulusan program dan studi dokumentasi. Data yang terkumpul kemudian dianalisis secara kualitatif. Kriteria dependabilitas, kredibilitas, transferabilitas, dan komfirmabilitas diterapkan untuk menjamin kualitas data. Hasil penelitian menunjukkan bahwa pengembangan program pendidikan dan pelatihan (diklat) calon kepala sekolah (CKS) di Indonesia secara umum senada dengan trend pengembangan program penyiapan CKS di berbagai negara. Kurikulumnya komperhensif dan koheren yang mengkaitkan antara pengetahuan teoritis yang diberikan melalui pembelajaran di kelas dengan pengetahuan dan keterampilan praktis melalui magang di sekolah pada tahap OJL. Diklat juga telah menerapkan pendekatan pembelajaran orang dewasa dan mengevaluasi tingkat penguasaan kompetensi peserta diklat. Model diklat ini dirasakan lulusan telah mendukung penguasaan kompetensi kepala sekolah yang mereka butuhkan saat menjabat. Namun demikian, hasil evaluasi menunjukkan bahwa masih terdapat beberapa aspek dari komponen pelaksanaan diklat yang perlu ditingkatkan. Aspek tersebut yaitu: relevansi kurikulum dengan tugas pekerjaan dan tanggung jawab kepala sekolah saat ini, kualitas mentor dan pementorannya saat peserta melaksanakan magang di sekolah.
Pengaruh Gaya Kepemimpinan Transformasional Kepala Sekolah Terhadap Etos Kerja Guru dan Staf
Authors: Fadhilah Muhammad Luthfi Zharfan , Suryadi Suryadi , Abubakar Abubakar 
Published: July 2021

Kepemimpinan transformasional berfokus pada pencapaian perubahan nilai-nilai, kepercayaan, sikap, perilaku, emosional, dan kebutuhan staf menuju perubahan yang lebih baik di masa depan. Penelitian ini bertujuan untuk mengetahui pengaruh gaya kepemimpinan transformasional kepala sekolah terhadap etos kerja guru dan staf. Sampel penelitian ini yaitu 56 guru dan staf di Sekolah Menengah Pertama Negeri 12 Bandung. Pengumpulan data dilakukan dengan kuesioner. Data yang terkumpul dianalisis secara kuantitatif menggunakan program Microsoft Excel 2016 dan SPSS 20 for windows. Hasil penelitian menunjukkan bahwa ada hubungan yang signifikan antara gaya kepemimpinan transformasional kepala sekolah dan etos kerja guru beserta staf dengan nilai koefisien sebesar 0,370. Selain itu, gaya kepemimpinan transformasional kepala sekolah berpengaruh sebesar 13,7% terhadap etos kerja guru dan staf. Jika gaya kepemimpinan transformasional kepala sekolah ditingkatkan sebesar 53,483 maka nilai etos kerja guru dan staf akan bertambah sebesar 0,260. Berdasarkan hasil penelitian tersebut, penelitian ini merekomendasikan perlunya pengembangan dan penerapan kepemimpinan transformasional kepala sekolah.
Media Sosial dan Connective Action: Studi Kasus Penggunaan Twitter sebagai Ruang Solidaritas selama Pandemi COVID-19
Authors: Kristianto Kristianto , Ramadhan Abdul Basith , Marsetyo Fernandito Dikky 
Published: July 2021

Tulisan ini membahas munculnya aksi solidaritas di media sosial Twitter. Dengan menggunakan kerangka teori connective action dan efektivitas gerakan di media sosial, tulisan ini bertujuan untuk menjelaskan bagaimana aksi solidaritas di Twitter muncul dan menjelaskan aktor yang terlibat di dalamnya. Selain itu, tulisan ini juga bertujuan untuk menjelaskan efektivitas dari aksi solidaritas. Penelitian dilakukan dengan analisis media sosial dan analisis konten. Penelitian menunjukkan bahwa aksi solidaritas yang muncul di Twitter merupakan respons atas situasi krisis akibat pandemi COVID-19. Meskipun merespons isu dalam rentang waktu yang sama dan menggunakan narasi yang serupa, aksi solidaritas yang dimunculkan oleh individu, organisasi, dan komunitas dilakukan secara personal dan tidak saling terikat secara langsung. Namun demikian, tidak semua aksi solidaritas mendapatkan impresi/engagement yang tinggi. Aktor yang menjadi opinion leader, yang dipengaruhi oleh faktor indegree, retweet dan mention, memiliki pengaruh besar dalam melakukan aksi solidaritas.

This article discusses the emergence of solidarity actions on Twitter social media. Using the framework of connective action and the effectiveness of social media movements, this paper aims to explain how solidarity actions on Twitter emerge and explain the actors involved in it. Besides, this paper also aims to explain the effectiveness of solidarity actions. The research was conducted with social media analysis and content analysis. Research shows that the solidarity action that appears on Twitter is a response to the crisis caused by the COVID-19 pandemic. Although responding to issues in the same time frame and using similar narratives, solidarity actions raised by individuals, organizations, and communities are carried out personally and are not directly tied to each other. However, not all solidarity actions received high impressions/engagement. Actors who are opinion leaders, who are influenced by indegree, retweet, and mention factors, have a big influence in carrying out solidarity actions.
Keywords: solidarity; crisis; opinion leader; twitter; connective action
Implementasi Program Jaminan Kesehatan Khusus Terpadu dalam Upaya Perlindungan dan Pemenuhan Hak Kesehatan Penyandang Disabilitas
Authors: Ardiyantini Rut Dwi 
Published: July 2021

Program Jamkesus Terpadu digulirkan oleh Pemerintah Daerah DIY melalui Bapel Jamkesos DIY untuk mewujudkan perlindungan dan pemenuhan hak kesehatan penyandang disabilitas dengan cara mempermudah, mendekatkan, memfasilitasi, dan memberikan jaminan. Penelitian ini bertujuan untuk mengetahui implementasi program tersebut di Kabupaten Gunungkidul. Penelitian ini menggunakan metode kualitatif dengan penekanan pada pendekatan deskriptif. Informan penelitian ini berjumlah 13 orang yang dipilih melalui teknik purposive sampling dan snowball sampling. Teknik pengumpulan data dilakukan dengan wawancara mendalam, observasi, dan dokumentasi. Hasil penelitian menunjukkan bahwa implementasi berdasarkan analisis keluaran program dari tujuh indikator, masih memuat masalah pada lima indikator tersebut yaitu cakupan, frekuensi, bias, ketepatan layanan, dan akuntabilitas. Namun demikian, hasil implementasi juga menunjukkan bahwa program tersebut telah memberikan dampak yang dapat dirasakan manfaatnya secara langsung. Akan tetapi, pada dampak jangka menengah menunjukkan masih belum sepenuhnya bisa dirasakan dan pada dampak jangka panjang juga masih menjadi harapan program untuk ke depannya.
Kata kunci: Jamkesus Terpadu, Penyandang Disabilitas, Perlindungan dan Pemenuhan Hak Kesehatan

Jamkesus Terpadu program is launched by the Provincial Government of DIY to realize the protection and fulfillment of health rights for persons with disabilities by making it easier, closer, facilitating, and giving the guarantee. This research aims to know the program’s implementation in Gunungkidul Regency. This research used a qualitative method with an emphasis on descriptive approach. There are 13 informants, who were selected through purposive sampling and snowball sampling techniques. Data collection is done through in-depth interview, observation, and documentation. The research result shows that the implementation based on an analysis of the program’s output from seven indicators that still contained problems there were five indicators namely coverage, frequency, bias, the accuracy of service, and accountability. Although the outcome of the program shows that the impact of the program can be felt directly. The medium-term impact shows not yet fully felt. Furthermore, the long-term impact is still the expectation of future programs.
Keywords: Jamkesus Terpadu, Persons with Disabilities, Protection and Fulfillment of Health Rights
Peran Lembaga Swadaya Masyarakat dalam Penetapan Taman Nasional Lore Lindu: Studi Yayasan Tanah Merdeka dalam Memperjuangkan Hak Masyarakat Katu
Authors: Bustam Mohamad 
Published: July 2021

Lembaga swadaya masyarakat ini berupaya memperjuangkan hak komunitas lokal dalam isu kebijakan penetapan kawasan taman nasional. Tujuan penulisan ini mengidentifikasi peran dan strategi Yayasan Tanah Merdeka (YTM) dalam memperjuangkan hak komunitas Orang Katu atas penetapan Kawasan Taman Nasional Lore Lindu Sulawesi Tengah. Data dikumpulkan menggunakan metode kualitatif dan disajikan secara deskriptif. Studi mengungkapkan YTM memainkan peran strategis dalam menciptakan hegemoni tandingan atas kebijakan penetapan kawasan Taman nasional Lore Lindu di wilayah komunitas Orang Katu. Hal ini dilakukan dengan membentuk kesadaran kolektif, melibatkan komunitas dalam gerakan akar rumput, mengembangkan strategi perjuangan melalui penyusunan dokumen pengelolaan sumber daya alam berbasis pengetahuan lokal serta, penggunaan terminologi masyarakat adat sebagai instrumen perjuangan yang dihubungkan dengan wacana hak global sehingga menjadi kekuatan yang konstitutif dalam arena politik pengelolaan sumber daya alam pada tingkat lokal.
Kata kunci: Lembaga swadaya masyarakat, gerakan masyarakat adat, kebijakan taman nasional

This non-governmental organization seeks to fight for the rights of local communities in the policy issue of setting the national park area. This paper aims to identify the role of Yayasan Tanah Merdeka (YTM) in the struggling rights of the Orang Katu community for the establishment of the Lore Lindu National Park Area. Data is collected using qualitative methods and presented descriptively. The study revealed that YTM played a strategic role in creating counter-hegemony over the policy of establishing Lore Lindu National Park in the Katu community area. Conducted by establishing collective awareness, involving communities in grassroots movements, the strategy is developed through the preparation of documents on the management of natural resources based on local knowledge as well as, the use of indigenous terminology that is connected with global rights discourse to become a constitutive force in the political arena of natural resource management at the local level.
Keywords: non-government organization, indigenous movement, national park policy
Unani Concept of Anaemia in Pregnancy (Hamla me Khoon ki Kami): An Overview
Authors: Zaidi S.M. Arif , Khatoon Khudeja 
Published: July 2021

Anaemia is a most common disorder of Indian women especially during the age of reproduction. Anaemia in pregnancy is a condition with effects that may deleterious to mothers and foetus. Indeed, it is a known risk factor for maternal and leads to foetal complications. However, women are much better aware now about their pregnancy related conditions than they were years ago. This is not just a feminist fad but common sense for the woman who knows what is likely to happen and will be better prepared for actions in pregnancy. The WHO considers iron deficiency to the largest International nutritional disorder. According to WHO anaemia in pregnancy is present when the concentration of haemoglobin in the peripheral blood is 11gms/100ml or less. As per American college of obstetrician and gynaecologist 60-100mgs of elemental iron per day prevents iron deficiency in a pregnant woman. In Unani system of medicine number of drugs and diets are available which have preventive and therapeutic role. Unani physicians paid special attention to child and mother care in general as well as in pregnancy. Natural medicines are economical, easily available and relatively free of side effects. So, the present topic highlights the use of Unani medicines providing iron supplements in the treatment of early and late pregnancy.
Keywords: Anaemia, Pregnancy, Foetal complications, Unani medicine
A Review on Deprescribing in Elderly
Authors: Babu Christy , George Lincy , Krishnakumar K. 
Published: July 2021

Deprescribing can be defined as the process of stopping a medication or reducing its dose to reduce adverse effects and improve health outcomes. Elderly people with co morbidities usually have a risk of adverse drug events and these events can only be treated by medicines. Despite the benefits offered by these medicines, older patients are at a high risk of harm caused by these medications. The use of multiple medications for treating the comorbidities may also leads to severe health problems. Deprescribing help to reduce the risk related to inappropriate medicines. Deprescribing is usually a patient centered process which helps to withdraw drugs which are harmful to be prescribed to older patients. Several explicit and implicit tools have been developed internationally to identify these inappropriate medications. Deprescribing of inappropriate medicines would help to reduces drug-related harm and improves the quality of life of older adults.
Keywords: Deprescribing, polypharmacy, older adults
Understanding the drug delivery through nails: a comprehensive review
Authors: BHATTACHARJEE BEDANTA , DEY NIKITA , BARMAN DHUNUSMITA , KARMAKAR ARKA , AHMED NASIMA 
Published: July 2021

The nail unit is the largest cutaneous musculo-skeletal appendage. The management of nail disorders is an onerous task owing to the disease manifestations and anatomical structure of the nail plate. The topical treatment of nail infections/disorders has been a centerpiece of nail research in the past few decades as it offers a much safer and focused alternative to conventional oral therapy. However, transungual delivery had its challenges. This necessitated a lookout for novel approaches that enhanced treatment efficacy and reduced treatment time. Moreover, curing the nail condition using topical delivery has been challenging due to the lack of a validated animal model to determine the efficacy of the formulation and to establish a mathematical model that can help in predicting the desirable attributes of the formulation and permeation of various molecules through the nail plate. This review is based on publications retrieved by a selective search in PubMed. The purpose of this review is to provide an overview of nail anatomy and its disorders, factors affecting nail delivery, diagnostic procedures, current approaches, and promising approaches to treat nail infections/disorders including nail lacquers and the role of permeation enhancers, in-vitro models. This review also covers current available treatments and treatments under clinical trial.
Keywords: Musculo-skeletal, Nail infection, Transungual, Mathematical model, In-vitro models.