bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum exosomal lncRNA SNHG7 is increased in NSCLC and predicts unfavorable prognosis
Authors: Zhang Zhenkui , Zhao Liqiang , Wang Zhijian , Yu Lixin , Sun Fenghua 
Published: October 2021

Abstract
BackgroundExosomal long non-coding RNAs (lncRNAs) are proposed as promising non-invasive biomarkers for clinical applications.AimsIn this study, we aimed to explore the potential of serum exosomal lncRNA SNHG7 for the diagnosis and prognosis prediction of non-small-cell lung cancer (NSCLC).MethodsA total of 128 patients with NSCLC and 80 healthy volunteers were enrolled. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to measure the expression level of serum exosomal lncRNA SNHG7 in all participants. Receiver operating characteristic (ROC) analysis was used to analyze the diagnostic value of serum exosomal lncRNA SNHG7 and CEA for NSCLC. The relationship between serum exosomal lncRNA SNHG7 expression and clinical characteristics of NSCLC was also assessed.ResultsSerum exosomal lncRNA SNHG7 levels were significantly upregulated in NSCLC patients compared to controls. In addition, serum exosomal lncRNA SNHG7 yield a ROC area under the curve (AUC) value of 0.856 with 77.34% sensitivity and 83.75% specificity for identifying NSCLC patients from normal controls. Combining serum exosomal lncRNA SNHG7 and CEA improved the diagnostic accuracy of NSCLC, with an AUC of 0.932 with 88.28% sensitivity and 86.25% specificity. Moreover, serum exosomal SNHG7 levels were significantly downregulated in post-operative blood samples whereas markedly higher in patients who experienced a relapse. Significant associations of elevated serum exosomal lncRNA SNHG7 expression with TNM stage, lymphatic invasion and lymph node metastasis were observed. High serum exosomal SNHG7 expression was associated with poorer survival and served as an independent prognostic factor for NSCLC.ConclusionsIn conclusion, our data demonstrates that serum exosomal SNHG7 expression might be a potential valuable biomarker for NSCLC detection and prognosis prediction.
Associations of Bedtime Schedules In Childhood With Obesity Risk In Adolescence
Authors: Mireku Michael O. , Fábelová Lucia 
Published: October 2021

Abstract

Objective: To investigate long-term associations of bedtime schedules and bedtimes in childhood with obesity risk and adiposity in later years.Methods: This cohort study is a secondary analysis of non-obese 7-year-old singleton children participating in the Millennium Cohort Study, a nationally representative prospective cohort of children born between 09/2000 and 01/2002 in the UK. Bedtimes and regularity of bedtimes of 7-year-olds were reported by parents. Obesity, from objectively body mass index, and bio-electric impedance body fat percentage (BFP) measurements at 11 and 14 years were considered outcomes. Results: In total, 11044 and 9898 children representing 87.3% and 78.3% of eligible sample were followed at 11 and 14 years, respectively. Obesity risk at 11 and 14 years was higher among children with never regular bedtimes at 7 years compared with those with always regular bedtimes (Risk Ratio, RR, 2.8 [95% CI, 1.8–1.4] and 2.3 [95% CI, 1.5–3.6], respectively). Increasing irregularity of childhood bedtime was associated with increasing risk of obesity at both 11 and 14 years in a dose–response manner (Ptrend <0.001; and Ptrend = 0.002, respectively). BFP at 11 years increased by 1.1% (95% CI, 0.8–1.5) for boys and 1.0% (95% CI, 0.6–1.4) for girls for every hour delay in childhood bedtime. Conclusions: Irregular bedtime schedules and later bedtimes in childhood were associated with increased risk of obesity in early- and mid-adolescence in a dose–response manner. There was marginal, but significant, increases in BFP during adolescence for children with later bedtimes.
Three-Dimensional Transient Finite Element Cooling Simulation For Injection Molding Tools
Authors: Chen Lu , Zhou Xiaowei , Huang Zhigao , Zhou Huamin 
Published: October 2021

Abstract
Plastic injection molding is one of the most popular manufacturing processes for mass production, and optimizing the mold cooling system is critical for reducing the cycle time and improving the final part quality. Conventional cooling simulation uses the boundary element method to perform the cycle-averaged analysis, which is a simplification due to computational resources limitation. This paper develops a three-dimensional transient cooling simulation method based on the finite element method, which can simulate the complex mold system accurately and efficiently. It is shown that this method finishes the transient cooling analysis in 478 seconds on the real-world injection molding mold with more than 6.9 million tetrahedral elements. Its accuracy is compared against the experimental results with the maximum temperature error less than 4%, and the average temperature error less than 1%.
Influence of Sex And Knee Joint Rotation On Patellofemoral Joint Stress Through A Mathematical Modelling Study
Authors: Tomoya Takabayashi , Mutsuaki Edama , Takuma Inai , Yuta Tokunaga , Masayoshi Kubo 
Published: October 2021

Abstract
Background: Females are two times as likely to experience patellofemoral pain syndrome (PFPS) than males; however, the reason for this sex difference remains unclear. Patellofemoral joint (PFJ) stress is believed to contribute to PFPS alterations through knee joint rotation alignment, but the influence of knee joint rotation conditions on PFJ stress is unclear. We aimed to investigate the influence of sex and knee joint rotation alignment on PFJ stress. Methods: Simulation ranges were set to knee joint flexion angles of 10°-45° (common to both sexes) and extension moments of 0-240 Nm (males) and 0-220 Nm (females). The quadriceps force and effective lever arm length at the quadriceps muscle were determined as a function of the knee joint flexion angle and extension moment. The PFJ contact area, which is specific to sex, and knee joint rotation was calculated from cadaver data, and PFJ stress was estimated. Results: In all knee joint rotation conditions, PFJ stress was higher in females than in males. Additionally, PFJ stress in males and females was the largest under neutral conditions compared with other rotation conditions. Conclusion: The results may be useful for understanding the underlying mechanisms contributing to the differences in PFPS in males and females.
A Cluster Randomized Trial of Delivery of Intermittent Preventive Treatment of Malaria in Pregnancy at the Community Level in Malawi
Authors: Rubenstein Beth , Chinkhumba Jobiba , Chilima Ethel , Kwizombe Collins , Malpass Ashley , Cash Shelby , Wright Katherine , Troell Peter , Nsona Humphrey , Kachale Fannie , Ali Doreen , Kaunda Evans , Lankhulani Sosten , Kayange Michael , Mathanga Don P , Munthali John , Gutman Julie 
Published: October 2021

Abstract
Background

Malaria in pregnancy doubles the risk of low birthweight and causes 11% of all neonatal deaths in sub-Saharan Africa. To prevent these and other adverse health consequences, the World Health Organization recommends administering intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine–pyrimethamine for all pregnant women at each antenatal care (ANC) visit, starting as early as possible in the second trimester. The target is for countries to administer a minimum of three doses (IPTp3+) to at least 85% of pregnant women.
Methods

A cluster randomized, controlled trial was conducted to assess the effect of delivery of IPTp by community health workers on the coverage of IPTp3+ and ANC visits in Malawi. Community delivery of IPTp was implemented within two districts in Malawi over a 21-month period, from November 2018 to July 2020. In control sites, IPTp was delivered at health facilities. Representative samples of women who delivered in the prior 12 months were surveyed at baseline (n=370, December 2017) and endline (n=687, August 2020). A difference in differences analysis was conducted to assess the change in coverage of IPTp and ANC over time, accounting for clustering at the health facility level.
Results

Overall IPTp coverage increased over the study period. At baseline, women received a mean of 2.3 IPTp doses (range 0–5 doses) across both arms, and at endline, women received a mean of 2.8 doses (range 0–9 doses). Despite overall increases, the change in IPTp3+ coverage was not significantly different between intervention and control groups (6.9%, 95% CI: -5.9%, 19.6%). ANC4+ coverage increased significantly in the intervention group compared with the control group, with a difference-in-differences of 25.3 percentage points (95% CI: 1.3%, 49.3%).
Conclusions

In order to reduce the burden of malaria in pregnancy, new strategies are needed to improve uptake of effective interventions such as IPTp. While community health workers’ delivery of IPTp did not increase uptake in this study, they may be effective in other settings or circumstances. Further research can help identify the health systems characteristics that are conducive to community delivery of IPTp and the operational requirements for effective implementation.
Trial registration:

ClinicalTrials.gov Identifier: NCT03376217. Registered December 6, 2017, https://clinicaltrials.gov/ct2/show/NCT03376217
Complete Genome Analysis of a Novel Alcaligenes Faecalis Phage vB_Af_QDWS595
Authors: Jing Yujie , Lin Hong , Ning Houqi , Wang Jingxue 
Published: October 2021

Abstract
A novel lytic phage named vB_Af_QDWS595 against Alcaligenes faecalis was isolated and characterized in this study. The genome of phage vB_Af_QDWS595 was sequenced and analyzed, and the result revealed that the phage contained a 88,795 bp of circular double-stranded DNA with 41.12% of GC content. There were 74 putative open reading frames (ORFs) and 11 tRNAs predicted in genome of phage vB_Af_QDWS595. Phenotype and phylogeny analysis indicated that this phage might be a new member within the family Schitoviridae. Phage vB_Af_QDWS595 is the first sequenced phage against Alcaligenes faecalis to the best of our knowledge.
Air, helium and water leakage in rubber O-ring seals with application to syringes
Authors: Huon Carine , Tiwari Avinash , Rotella Cinzia , Mangiagalli Paolo , persson bo 
Published: October 2021

Abstract
We study the leakage of fluids (liquids or gases) in syringes with glass barrel, steel plunger and rubber O-ring stopper. The leakrate depends on the interfacial surface roughness and on the viscoelastic properties of the rubber. Random surface roughness is produced by sandblasting the rubber O-rings. We present a very simple theory for gas flow which takes into account both the diffusive and ballistic flow. The theory shows that the interfacial fluid flow (leakage) channels are so narrow that the gas flow is mainly ballistic (the so called Knudsen limit). We compare the leakrate obtained using air and helium. For barrels filled with water we observe no leakage even if leakage occurs for gases. We interpret this as resulting from capillary (Laplace pressure
or surface energy) effects.
Estimation of Some Trace Metals Contamination in Waste Newspapers
Authors: Ahmed Hatem , Johar Ahmed , Janjua Muhammad , Alhafez Nada 
Published: October 2021

Abstract
In the current study, different types of waste newspapers in the Middle East and Asia were analyzed qualitatively and quantitatively by Inductively Coupled Plasma and Optical Emission Spectrometry (ICP OES) for trace metals contamination. 11 samples from different newspapers collected by the researchers from local markets were analyzed for arsenic (As), cadmium (Cd), chromium (Cr), nickel (Ni), lead (Pb), aluminum (Al), and zinc (Zn). Trace metals concentrations in the samples were compared with those established by the various specialized councils. Digestion solution for samples digested in this study included 10 ml of 69% nitric acid and 2 ml of 30% hydrogen peroxide. Based on the results for light fonts, the average content of As, Cd, Cr, Ni, and Pb was (2.8, 1.5, 6.9, 5.6, and 5.0 µgL-1), while was (3.4 and 0.18 mgL-1) for Al, and Zn, respectively. In bold fonts, the content of As, Cd, Cr, Ni, and Pb was (4.9, 2.4, 9.1, 7.9, and 7.0 µgL-1, respectively), while Al and Zn were (5.7 mg/l and 0.32 mgL-1) respectively. In the pictures, the levels of As, Cd, Cr, Ni, and Pb were (6.1, 2.99, 11.2, 9.4, and 8.99 µgL-1), while Al and Zn were (8.2, and 0.39 mgL-1), respectively. The results showed that all levels of trace metals under study were within the specialized global councils' permitted limits, but the presence of trace metals in waste newspapers, even within the permitted limits, remains a source of great concern, as exposure to these elements has a significant impact on consumer health.
Multivariate Weighted Isotonic Regressive Modest Adaptive Boosting Based Resource-Aware Routing In WSN
Authors: Muruganandam N. , Venkatraman V. , Venkatesan R. 
Published: October 2021

Abstract
WSN includes a scenario where huge amount of sensor nodes are distributed to monitor environmental conditions with route collected data towards sinks via the internet. WSNs efficiently manage the wider network with available resources, such as residual energy and wireless channel bandwidth. Therefore, routing algorithm is important to enhance battery-constrained networks. Many existing techniques are developed for balancing consumption of energy but efficient routing was not achieved. Multivariate Weighted Isotonic Regressive Modest Adaptive Boosting based Resource Aware Routing (MWIRMAB-RAR) technique is introduced for enhancing routing. The MWIRMAB-RAR technique includes a different process namely resource-aware node selection, route path discovery, and data transmission. Initially, the MWIRMAB-RAR technique uses the Modest Adaptive Boosting technique uses the Multivariate Weighted Isotonic Regression function for detecting resource-efficient sensor nodes for effective data transmission. After that, multiple route paths are established based on the time of flight method. After establishes route path, source node sends data packets to sink node via resource-efficient nodes. The data delivery was enhanced and minimizes packet loss as well as delay. The simulation analysis is carried out on certain performance factors such as energy consumption, packet delivery ratio, packet loss rate, and delay with number of data packets and sensor nodes. The obtained evaluation indicates MWIRMAB-RAR outperforms well in terms of increasing data packet delivery and reduces consumption of energy, packet loss rate, and delay.
AVALIAÇÃO DA EFICIÊNCIA DA APLICAÇÃO DOS ROYALTIES DA MINERAÇÃO NO DESENVOLVIMENTO SOCIAL DOS MUNICÍPIOS MINEIROS
Authors: Rodrigues Alexandre de Cássio , Moreira Márcia Athayde , Colares Ana Carolina Vasconcelos 
Published: October 2021

Tendo os royalites da mineração como origens de recursos públicos dos municípios nos quais a atividade mineral ocorre, essa pesquisa tem como objetivo analisar, por meio de indicadores sociais, se a aplicação dos royalties da mineração tem impactado positivamente no desenvolvimento dos municípios mineiros. Para tanto, utilizou-se na pesquisa documental a prestação de contas anual das prefeituras e câmaras municipais, informações sobre população municipal no site do IBGE e obtido o Índice Firjan de Desenvolvimento Municipal, sendo posteriormente utilizadas técnicas de regressão linear e análise de clusters. Os resultados indicam que o aumento da dependência dos royalties da mineração implica na redução do desenvolvimento humano dos municípios de base mineral. Além disso, não foram encontradas evidências de que a atividade mineral proporcione altos níveis de geração de emprego e distribuição de renda. Portanto, é necessário que esses recursos sejam geridos de forma mais eficiente, priorizando-se projetos que estimulem a diversificação econômica dos municípios. Palavras-chave: Royalties da mineração; Gestão por indicadores; Eficiência governamental; Desenvolvimento humano.
Characterizing Product Performance as Visual Imaging in Influencing Designer Design Thinking in Product Development
Authors: Nik Aziz Nik Nor Azidah , Daimin Ghazali , Vermol Verly Veto , Zainal Abidin Shahriman 
Published: October 2021

The main purpose of this research is to explore Product Design Images influencing factors to designers prior to Visual Methods to be presented within the Design Research context at the stage of Design Activity. The researcher has chosen the Sequential Explanatory Design to easily communicate the procedures for this mixed-method study. The significance of this project enables researchers to discover the underlying relationship and potential of Research Photography in the product development process for product performance analysis. Qualitative data through the Verbal Protocol Analysis model will potentially be supporting the researcher to investigate within the activity of designers understanding product performances and user needs.
Keywords: Product Design; Visual Methods; Photography; Design Activity
eISSN: 2398-4287 © 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6iSI6.3041
Strategizing Alternative Visual Artworks Medium through Upcycle Textile
Authors: Mohamed Amin Noor Hidawati , Husain Abdul Halim , Mohamed Shaari Zuriati , Vermol Verly Veto 
Published: October 2021

This research aims to provide a procedural process of recycled textiles as an alternative medium in visual artwork. In this study, recycled textiles are not processed to become fibers. However, textile waste will be segregated, selected, sorted, cut and combined as new materials through vernacular techniques. The study is divided into a Recycled Textile Analysis Innovation (RTAI) and a Recycled Textile Production (RTP) for visual artwork adapting from Multiple Creative Talent by Calvin W. Tylor. The significance of this study will be showcased through the 'Lestari Perca' exhibition to promote awareness in recycling textile through art-making.
Keywords: Recycle textile; Alternative Medium; Visual Artwork; Fine Art
eISSN: 2398-4287 © 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6iSI6.3043
Model Agromarine Berkelanjutan Melalui Integrasi Teknologi Karamba Jaring Apung (KJA),Rumpon Dasar Ramah Lingkungan dan Sero Sistem Kluster di Sulawesi Tenggara
Authors: Nadia La Ode Abdul Rajab , Abdullah Abdullah , Takwir Amadhan 
Published: October 2021

Model of agro-marine is a solution for an integrated and sustainable coastal management in coastalcommunities. The contribution of sero in combination with bottom fish aggregating device (FAD) isimportant as the supplier of broodstock and diet for fish reared on floating cages. The objective of thepresent study was to increase aquaculture production sustainably in floating cages and to enhancebroodstock production, feed-fish stock and fish consumption harvested by sero and FAD in order togenerate integrated business incubation in favor of fish consumption in Southeast Sulawesi. The studywas conducted in Staring Bay, South Konawe Regency, Southeast Sulawesi. This study identifiedbroodstock and consumed fish harvested from sero and FAD, the collection of fish to be stocked infloating cages, broodstock adaptation and fish rearing on floating cages, and fish production to reachmarketable size. Results showed that there were 1,500 broodstock of Caranx sp., harvested from sero,and 180 broodstock of lobster with the size ranges between 200 and 220 g/individual collected bybamboo fishing trap (bubu) placed in FAD. During the study, the survival of Caranx ignobilis, andlobster reached between 84.25-88.15% and 92.33%, respectively. The fish were fed fresh trash fishharvested from sero and FAD. The production of fish consumption post harvest ranged from 380.5-560 kg/month. The agro-marine model contributes to an optimal production and minimizes productioncost of aquaculture and also increases fish consumption sustainably.
Sanksi Pidana Terhadap Pelaku Tindak Pidana Penganiayaan yang Mengakibatkan Luka Berat
Authors: Kusuma Ngurah Arya , Dewi Anak Agung Sagung Laksmi , Widyantara I Made Minggu 
Published: October 2021

Arah peraturan hukum bermaksud menciptakan hukum sebagai aturan yang memberikan proteksi bagi kewenangan masyarakat dan menyelamatkan kehidupan keturunan di masa depan. Sistem hukum dibeberapa negara berbeda-beda, di Indonesia sistem hukumnya masih kurang baik, negara dalam aplikasinya terus menemui modernisasi dan tidak ada satu kawasan pun yang dapat menolaknya. Hukum Pidana di Indonesia menjadi salah satu dasar yang sungguh berguna dalam melaksanakan suatu keadilan. Kitab Undang-Undang Hukum Pidana adalah aturan yang stabil dalam rangka menetapkan tindakan yang terlarang dan memiliki sanksi yang tegas bagi yang melanggarnya. Tindakan penganiayaan yang kita jumpa dari beragam sumber menjadi pertanda bahwa hal tersebut tidak lepas dari perilaku masyarakat yang kurang pemantauan baik itu dari faktor rendahnya tingkat pendidikan dan pengaruh lingkungan pergaulan yang kurang baik. Adapun rumusan masalah 1). Bagaimana Pertimbangan Hakim dalam memutus perkara tentang penganiayaan yang mengakibatkan luka berat ? 2). Bagaimanakah sanksi pidana dalam tindak pidana penganiayaan yang mengakibatkan luka berat ? Tipe penelitian yang dilakukan penelitian hukum normative. dasar pertimbangan hakim menelaah tentang kebenaran dari kasus yang ditangani terlebih dahulu, karena hakim diwajibkan untuk menegakkan hukum dan keadilan yang tidak memihak, hakim untuk dapat memberikan pertimbangan dalam memutuskan suatu perkara dengan berdasarkan Ketuhanan Yang Maha Esa dan Secara sungguh-sungguh tentang hal-hal yang mengenai memberatkan dan meringankan pidana. Sanksi pidana yang dijatuhkan adalah pidana penjara selama 1 (satu) tahun yang dikurangi masa tahanan.