bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGGUNAAN INFORMASI AKUNTANSI PADA PELAKU UMKM
Authors: Kaukab M. Elfan , Nur setya handayani  , Yuwono Wiji 
Published: July 2021

Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang mempengaruhi penggunaan informasi akuntansi pada pelaku UMKM di KabupatenWonosobo. Variabel independen dalam penelitian ini adalah pengetahuan akuntansi, pengalaman usaha, motivasi kerja, jenjang pendidikan dan skala usaha. Sedangkan variabel dependennya adalah penggunaan informasi akuntansi. Metode pengumpulan data dalam penelitian ini menggunakan simple random sampling, diperoleh sampel 100. Metode pengumpulan data dalam penelitian ini menggunakan kuesioner. Penelitian ini menggunakan teknik analisis data statistik regresi dengan bantuan SPSS. Hasil penelitian ini menunjukkan pengetahuan akuntansi, pengalaman usaha, motivasi kerja, jenjang pendidikan, dan skala usaha berpengaruh positif terhadap penggunaan informasi akuntansi. Keterbatasan dalam penelitian ini adalah koefisien determinasi sebesar 54,1%. Artinya, masih terdapat variabel bebas lainya yang bisa mempengaruhi penggunaan informasi akuntansi yang tidak diteliti dalam penelitian ini. Agenda penelitian yang akan datang disarankan memperluas periode pengamatan yang lebih lama untuk mendapatkan hasil yang lebih baik dan menambah variabel penelitian yang berpengaruh terhadap penggunaan informasi akuntansi.
PEMANFAATAN APLIKASI WHATSAPP SELAMA PANDEMI COVID-19 SEBAGAI SARANA DISKUSI PADA MAHASISWA PENDIDIKAN MATEMATIKA
Authors: Nuraini  , Afghohani Afif , Exacta Annisa Prima 
Published: July 2021

Penelitian ini bertujuan untuk mengetahui bagaimana respons mahasiswa terhadap pemanfaatan aplikasi Whatsapp sebagai sarana diskusi pembelajaran selama pandemi Covid-19. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Data dalam penelitian ini diperoleh dari hasil pengisian angket dan wawancara. Sumber data dalam penelitian ini adalah subjek dari mana data diperoleh, yaitu mahasiswa semester VI pendidikan matematika Universitas Veteran Bangun Nusantara Sukoharjo. Teknik analisis data yang digunakan adalah reduksi data, penyajian data dan penarikan kesimpulan. Hasil analisis angket menunjukkan bahwa persentase rata-rata respons mahasiswa terhadap pemanfaatan aplikasi WhatsApp sebagai sarana diskusi pembelajaran berada pada kategori positif dengan persentase sebesar 78,6%. Sedangkan berdasarkan analisis hasil wawancara, mahasiswa juga memberikan respons yang positif terhadap pemanfaatan aplikasi WhatsApp sebagai sarana diskusi pembelajaran. Pada penelitian ini pemeriksaan keabsahan data menggunakan teknik triangulasi metode, yaitu dengan membandingkan hasil penelitian dengan hasil wawancara. Berdasarkan perbandingan analisis data dengan angket dan wawancara, dapat disimpulkan bahwa respons mahasiswa dalam pemanfaatan aplikasi WhatsApp sebagai sarana diskusi berada pada kategori sangat positif, menuju positif, melampaui positif, dan menuju kurang positif.
Kata Kunci: WhatsApp;respons;sarana diskusi
Are There Any Traces of Pinus uliginosa in the Stołowe Mountains Outside the Wielkie Torfowisko Batorowskie and Błędne Skały?
Authors: Boratyńska Krystyna , Gołąb Zbigniew , Łabiszak Bartosz , Niemczyk Wioletta , Sobierajska Karolina Irena , Ufnalski Krzysztof , Wachowiak Witold , Boratyński Adam 
Published: July 2021

AbstractPinus sylvestris(Scots pine) and taxa from theP. mugo(mountain pine) complex hybridize in contact zones producing morphologically-intermediate fertile hybrids. However, the hybrid specimens sometimes express only theP. sylvestrisphenotype. Such cryptic hybrids were detected amongP. sylvestrisandP. uliginosain the western part of Błędne Skały in the Stołowe Mountains, where the pines grow on the tops of sandstone rocks and phenotypically resembleP. sylvestris,P. uliginosa, andP. mugo. Hybrids with theP. sylvestrisphenotype could be potentially present in other relic populations of this species in these mountains. During the present study, the hybrids were identified only in the area of Błędne Skały based on chloroplast and mitochondrial markers, morphological differentiation of various needle and cone traits, and phenotype assessments of the trees during sampling. These hybrids included three cryptic hybrids ofP. sylvestris×P. mugowith theP. sylvestrisphenotype and one displaying the phenotype ofP. uliginosa. The other populations analyzed represented Scots pine with no evidence of hybridization withP. uliginosaand/orP. mugo. Biometric data on the cone and needle morphology also suggest possible hybridization within theP. mugocomplex on Błędne Skały. The results indicate that hybridization takes place in this population but not in neighboring populations despite the possible connection by pollen-mediated gene flow.
Étude comparative de la densité et du déplacement des Desmans des Pyrénées Galemys pyrenaicus (É. Geoffroy Saint-Hilaire, 1811) par une méthode non invasive
Authors: LIM Melody , BLANC Frédéric , MICHAUX Johan , PIGNEUR Lise-Marie , GILLET François , MARC Daniel , PONCET Émile , NÉMOZ Mélanie 
Published: July 2021

Espèce protégée et en régression sur l’ensemble de son aire de répartition, le Desman des Pyrénées Galemys pyrenaicus (É. Geoffroy Saint-Hilaire, 1811) reste une espèce mal connue malgré les programmes d’actions en faveur de sa conservation mis en œuvre en France depuis 2010. Le manque de connaissance sur la densité des populations et les déplacements des individus nous ont poussés à réaliser une étude de suivi de six populations de Desman répartie sur six sites pyrénéens connus pour abriter l’espèce. La méthode retenue pour cette étude a été l’analyse génétique des fèces nécessitant un protocole non invasif et moins coûteux que les captures ou les suivis par radiopistage. Certaines crottes ont permis de contacter des individus à plusieurs reprises et d’analyser leurs déplacements. L’individualisation des crottes a également permis d’estimer une densité minimale d’individus sur 1,5 km de cours d’eau prospecté réparti sur 3 km, ou encore sur des portions plus restreintes de 250 mètres. Ainsi, les résultats confirment la mobilité du Desman mais aussi son caractère nomade et non territorial. Un des sites n’a cependant pas pu rentrer dans l’analyse des données, car soumis à une pollution menant à la disparition de l’espèce pendant quelques années. Les analyses génétiques ont montré l’efficacité des prospections avec des résultats positifs au Desman pour chaque échantillon prélevé supposé appartenir à l’espèce. Cependant, ils confirment aussi la difficulté de détectabilité de l’espèce malgré sa présence et la nécessité de la prendre en compte, même si elle semble absente à un instant donné sur un site, notamment dans les projets d’aménagement de cours d’eau, afin de respecter la continuité écologique nécessaire à ses déplacements et aux mélanges génétiques des populations.
Contribuições do enfermeiro para o apoio matricial em saúde mental na atenção básica
Authors: Pinheiro Guilherme Emanuel Weiss , Kantorski Luciane Prado 
Published: July 2021

Objetivo: identificar as contribuições do enfermeiro no contexto do apoio matricial em saúde mental na atenção básica. Método: pesquisa qualitativa, com base na Avaliação de Quarta Geração, realizada com trabalhadores dos núcleos de apoio matricial e das equipes de referência de um município do sul do Brasil. Foram realizadas 84 horas de observação, 15 entrevistas e dois grupos de validação dos dados, entre dezembro de 2018 e fevereiro de 2019. A análise ocorreu pelo método comparativo constante. Resultados: o enfermeiro contribui com o apoio matricial à medida que atua na inclusão dos núcleos junto às equipes, no exercício do gerenciamento e da liderança, do cuidado compartilhado e na mediação das ações de saúde mental no território. Conclusão: a liderança do enfermeiro é decisiva, pois ao concentrar funções de gerenciamento e assistência, colabora na construção de alternativas de cuidado às pessoas em sofrimento mental na atenção básica.
Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell
Authors: Girsang Ermi , Ginting Chrismis N. , Lister I Nyoman Ehrich , Gunawan Kamila yashfa , Widowati Wahyu 
Published: July 2021

BackgroundSkin aging is the most common dermatological problem caused by intrinsic and extrinsic factor, such as exposure to (ultraviolet) UV rays. Chlorogenic acid (CA) is a phenolic compound which is known for its antioxidant properties against oxidative stress.ObjectiveThis study investigates the antiaging and anti-inflammatory properties of CA on UV-induced skin fibroblast cells.MethodsAnti-inflammatory properties of CA were assessed by measuring inflammatory-related proteins IL-1β and TNF-α, while antiaging properties of CA were assessed by measuring reactive oxygen species (ROS), apoptosis, live and necrotic cells, and COL-3 gene expression level.ResultsTreating UV-induced skin fibroblast cells with CA decreased the level of ROS, IL-1β, TNF-α, apoptotic cells, and necrotic cells and increased live cells and COL-3 gene expression.ConclusionCA has the potential as the protective compound against inflammation and aging by decreasing the level ROS, pro-inflammatory cytokines IL-1β and TNF-α, apoptotic cells, and necrotic cells and by increasing live cells and COL-3 gene expression.
Construction and validation of a 15-gene ferroptosis signature in lung adenocarcinoma
Authors: Tu Guangxu , Peng Weilin , Cai Qidong , Zhao Zhenyu , Peng Xiong , He Boxue , Zhang Pengfei , Shi Shuai , Tao Yongguang , Wang Xiang 
Published: July 2021

Background
Ferroptosis is a novel form of programmed cell death characterized by the excessive accumulation of intracellular iron and an increase in reactive oxygen species. Emerging studies have shown that ferroptosis plays a vital role in the progression of lung adenocarcinoma, but the effect of ferroptosis-related genes on prognosis has been poorly studied. The purpose of this study was to explore the prognostic value of ferroptosis-related genes.

Methods
Lung adenocarcinoma samples were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. The least absolute shrinkage and selection operator (LASSO) Cox regression algorithm was used to establish a predictive signature for risk stratification. Kaplan–Meier (K–M) survival analysis and receiver operating characteristic (ROC) curve analysis were conducted to evaluate the signature. We further explored the potential correlation between the risk score model and tumor immune status.

Results
A 15-gene ferroptosis signature was constructed to classify patients into different risk groups. The overall survival (OS) of patients in the high-risk group was significantly shorter than that of patients in the low-risk group. The signature could predict OS independent of other risk factors. Single-sample gene set enrichment analysis (ssGSEA) identified the difference in immune status between the two groups. Patients in the high-risk group had stronger immune suppression, especially in the antigen presentation process.

Conclusions
The 15-gene ferroptosis signature identified in this study could be a potential biomarker for prognosis prediction in lung adenocarcinoma. Targeting ferroptosis might be a promising therapeutic alternative for lung adenocarcinoma.
A Mechanistic Probe into 1,2‐cis Glycoside Formation Catalyzed by Phenanthroline and Further Expansion of Scope
Authors: Li Jiayi , Nguyen Hien M. 
Published: July 2021

AbstractPhenanthroline, a rigid and planar compound with two fused pyridine rings, has been used as a powerful ligand for metals and a binding agent for DNA/RNA. We discovered that phenanthroline could be used as a nucleophilic catalyst to efficiently access high yielding and diastereoselective α‐1,2‐cis glycosides through the coupling of hydroxyl acceptors with α‐glycosyl bromide donors. We have conducted an extensive investigation into the reaction mechanism, wherein the two glycosyl phenanthrolinium ion intermediates, a 4C1 chair‐liked β‐conformer and a B2,5 boat‐like α‐conformer, have been detected in a ratio of 2:1 (β:α) using variable temperature NMR experiments. Furthermore, NMR studies illustrate that a hydrogen bonding is formed between the second nitrogen atom of phenanthroline and the C1‐anomeric hydrogen of sugar moiety to stabilize the phenanthrolinium ion intermediates. To obtain high α‐1,2‐cis stereoselectivity, a Curtin‐Hammett scenario was proposed wherein interconversion of the 4C1 chair‐like β‐conformer and B2,5 boat‐like α‐conformer is more rapid than nucleophilic addition. Hydroxyl attack takes place from the α‐face of the more reactive 4C1 β‐phenanthrolinium intermediate to give an α‐anomeric product. The utility of the phenanthroline catalysis is expanded to sterically hindered hydroxyl nucleophiles and chemoselective coupling of an alkyl hydroxyl group in the presence of a free C1‐hemiacetal. In addition, the phenanthroline‐based catalyst has a pronounced effect on site‐selective couplings of triol motifs and orthogonally activates the anomeric bromide leaving group over the anomeric fluoride and sulfide counterparts.magnified image
BODIPY‐Based Photodynamic Agents for Exclusively Generating Superoxide Radical over Singlet Oxygen
Authors: Teng Kun‐Xu , Chen Wen‐Kai , Niu Li‐Ya , Fang Wei‐Hai , Cui Ganglong , Yang Qing‐Zheng 
Published: July 2021

AbstractDeveloping Type‐I photosensitizers is considered as an efficient approach to overcome the deficiency of traditional photodynamic therapy (PDT) for hypoxic tumors. However, it remains a challenge to design photosensitizers for generating reactive oxygen species by the Type‐I process. Herein, we report a series of α,β‐linked BODIPY dimers and a trimer that exclusively generate superoxide radical (O2−.) by the Type‐I process upon light irradiation. The triplet formation originates from an effective excited‐state relaxation from the initially populated singlet (S1) to triplet (T1) states via an intermediate triplet (T2) state. The low reduction potential and ultralong lifetime of the T1 state facilitate the efficient generation of O2−. by inter‐molecular charge transfer to molecular oxygen. The energy gap of T1‐S0 is smaller than that between 3O2 and 1O2 thereby precluding the generation of singlet oxygen by the Type‐II process. The trimer exhibits superior PDT performance under the hypoxic environment.
Synergistical Dipole–Dipole Interaction Induced Self‐Assembly of Phenoxazine‐Based Hole‐Transporting Materials for Efficient and Stable Inverted Perovskite Solar Cells
Authors: Cai Ning , Li Fengzhu , Chen Yatong , Luo Ruixi , Hu Tonghui , Lin Francis , Yiu Shek‐Man , Liu Danjun , Lei Dangyuan , Zhu Zonglong , Jen Alex K.‐Y. 
Published: July 2021

AbstractDelicately designed dopant‐free hole‐transporting materials (HTMs) with ordered structure have become one of the major strategies to achieve high‐performance perovskite solar cells (PSCs). In this work, we report two donor‐π linker‐donor (D‐π‐D) HTMs, N01 and N02, which consist of facilely synthesized 4,8‐di(n‐hexyloxy)‐benzo[1,2‐b:4,5‐b′]dithiophene as a π linker, with 10‐bromohexyl‐10H‐phenoxazine and 10‐hexyl‐10H‐phenoxazine as donors, respectively. The N01 molecules form a two‐dimensional conjugated network governed by C−H⋅⋅⋅O and C−H⋅⋅⋅Br interaction between phenoxazine donors, and synchronously construct a three‐dimension lamellar structure with the aid of interlaminar π–π interaction. Consequently, N01 as a dopant‐free small‐molecule HTM exhibits a higher intrinsic hole mobility and more favorable interfacial properties for hole transport, hole extraction and perovskite growth, enabling an inverted PSC to achieve a very impressive power conversion efficiency of 21.85 %.
Cultivating practices of inclusion towards same‐sex families in Italy: A comparison among educators, social workers, and healthcare professionals
Authors: Everri Marina , Mancini Tiziana , O'Brien Valerie , Fruggeri Laura 
Published: July 2021

AbstractLGB+ parented families in recent years are becoming more visible, but limited information exists about how professionals interact with people in these family forms. This study used the framework of intergroup contact theory to investigate whether contact with lesbians and gay men, same‐sex couples, and same‐sex parents respectively increase inclusive practices towards same‐sex families, and whether this association is mediated by professionals' prejudice and endorsement of same‐sex families' rights. A questionnaire with scales on: (a) intergroup contact, (b) professionals' orientation towards same‐sex families' inclusive practices, (c) professionals' prejudices, and (d) support of same‐sex couples' rights was administered to 460 professionals (9.8% males) working in social (N = 103), education (N = 156), and healthcare (N = 201) services in Italy. Path analysis was used to test the prediction that contact increases professionals' intention to embrace inclusive practices towards same‐sex families through the mediation of both prejudice and support to same‐sex couples' rights to have and raise children. Results showed that contact reduced prejudices towards same‐sex families and increased the endorsement of same‐sex families' rights, which in turn favoured professionals' willingness to modify their practices to include these family forms. Implications for the training and development of inclusive models are discussed. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
Chemical Composition and Antioxidant, Antiparasitic, Cytotoxicity and Antimicrobial Potential of the Algerian Limonium Oleifolium Mill. Essential Oil and Organic Extracts
Authors: Mennai Imad , Lamera Esma , Slougui Nabila , Benaicha Brahim , Gasmi Salim , Samai Zakaria , Rahmouni Naima , Bensouici Chawki , C. G. A. Pinto Diana 
Published: July 2021

AbstractThis work aimed to investigate, for the first time, the chemical composition, antioxidant, antiparasitic, cytotoxicity, and antimicrobial activities of the aromatic plant Limonium oleifolium Mill. essential oil (EO) and organic extracts. L. oleifolium aerial parts essential oil was analyzed by GC‐FID and GC‐MS, and 46 constituents representing 98.25±1.12 % of the oil were identified. γ‐Muurolene (10.81±0.07 %), cis‐caryophyllene (7.71±0.06 %), o‐cymene (7.07±0.01 %) and α‐copaene (5.02±0.05 %) were the essential oil main compounds. The antioxidant activity of L. oleifolium EO and organic extracts (MeOH, CHCl3, AcOEt, BuOH) was explored using 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), ABTS, β‐carotene/linoleic acid, cupric reducing antioxidant capacity (CUPRAC), and ferric reducing power assays. The results showed that L. oleifolium EO exhibit antioxidant capacity (IC50=17.40±1.32 μg/mL for DPPH assay, IC50=29.82±1.08 μg/mL for β‐carotene assay, IC50=25.23±1.01 μg/mL for ABTS assay, IC50=9.11±0.08 μg/mL for CUPRAC assay and IC50=19.41±2.06 mg/mL for reducing power assay). Additionally, the EO showed significant activity against trophozoite form of Acanthamoeba castellanii (IC50=7.48±0.41 μg/mL) and promastigote form of Leishmania amazonensis (IC50=19.36±1.06 μg/mL) and low cytotoxicity on murine macrophages (LC50 90.23±1.09 μg/mL), as well as good antimicrobial activity against Staphylococcus aureus, Escherichia coli, Klebsiella oxytoca, and Pseudomonas aeruginosa. These results suggest that L. oleifolium essential oil is a valuable source of bioactive compounds presenting antioxidant, antiparasitic, and antimicrobial activities. Furthermore, it is considered nontoxic.
PEGylated Oligothioetheramide Prodrugs Activated by Host Serum Proteases
Authors: Artim Christine M. , Kunala Manisha , O'Leary Meghan K. , Alabi Christopher A. 
Published: July 2021

AbstractDue to the increasing prominence of antibiotic resistance, novel drug discovery and delivery approaches targeting bacteria are essential. In this work we evaluate a prodrug design to improve the cytotoxic profile of polycationic oligothioetheramides (oligoTEAs), which are promising antimicrobials. Herein we chemically modify the oligoTEA, PDT‐4G, with a polyethylene glycol (PEG) and show that 1, 2, and 5 kDa PEGs mitigate cytotoxicity. As PEGylation reduces antibacterial activity, we evaluate two peptide linkers which, unlike oligoTEAs, are susceptible to proteolytic cleavage in serum. To gain insight into the prodrug reactivation, two linkers were tested, the 5‐residue peptide sequence LMPTG, and the dipeptide sequence VC‐PABC. In the presence of 20 % serum, prodrugs made with the VC‐PABC linker successfully inhibited bacterial growth. Overall, we observed reactivation of oligoTEAs facilitated by serum protease cleavage of the peptide linkers. This work opens the door to the future design of antimicrobial prodrugs with tunable release profiles.
Endoscopic sinus surgery for foreign body extraction in an adult patient
Authors: Cardella Arianna , Preti Andrea , Gera Roberto , Ottaviani Francesco , Mozzanica Francesco 
Published: July 2021

AbstractForeign bodies are an unusual indication for endoscopic sinus surgery. If outpatient extraction is not possible and acute sinusitis ensues, thorough exploration and extended surgical dissection should be considered to clear the nasal cavities.
A case of severe paraneoplastic itch resistant to antihistamines and responding to serotonin reuptake inhibitors
Authors: Werda Ines , Feki Jihene , Khemiri Souhir , Ben Kridis Wala , Khanfir Afef 
Published: July 2021

AbstractThis article covers an interesting topic. Paraneoplastic pruritus is rare but can be severe. It can sometimes be resistant to usual treatments. In our case, it was resistant to antihistamines but was relieved by inhibitors of serotonin scrapping.
Post‐COVID worsening of a Parkinson's disease patient
Authors: Boika Aliaksandr V. , Sialitski Mikhail M. , Chyzhyk Veranika A. , Ponomarev Vladimir V. , Fomina Elena G. 
Published: July 2021

AbstractWorsening of clinical symptoms after COVID‐19 infection and misregulation of CD4 and CD8 T‐cell numbers may be revealed in PD patients. Immunological changes may be a source of clinical worsening of the patient.
Successful treatment of critical coronavirus disease 2019 in a patient with lung cancer concomitant with pembrolizumab‐induced arthritis by methylprednisolone, baricitinib, and remdesivir
Authors: Oda Naohiro , Miyoshi Keiji , Morichika Daisuke , Beika Yuka , Taki Takahiro , Mitani Reo , Okada Toshiaki , Takata Ichiro 
Published: July 2021

AbstractCOVID‐19 in cancer patients on immunosuppressive agents for the treatment of immune‐related adverse events of immune checkpoint inhibitors can rapidly deteriorate. The combination therapy with methylprednisolone, baricitinib, and remdesivir may be effective for critical COVID‐19, and further clinical trials are warranted.
Recurrent Kaposi sarcoma of the ear in an HIV‐negative patient: A case report with review of the literature. Is ear a predilection site for Kaposi sarcoma in HIV‐negatives?
Authors: Etesami Ifa , Kalantari Yasamin , Ghanadan Alireza , Rezayat Azadeh 
Published: July 2021

AbstractWhile Kaposi sarcoma (KS) of the head and neck is common in HIV‐positives, it is a rare presentation in HIV‐negatives. It is important to consider KS in the differential diagnosis of ear lesions in HIV‐negative patients.
The diagnostic challenge of abdominal tuberculosis in nonendemic countries: A case series from a tertiary hospital in Germany
Authors: Bertlich Maya , Paparoupa Maria , Weckauf Helgard , Wittig Andreas , Linnemüller Stephan , Schuppert Frank 
Published: July 2021

AbstractAbdominal tuberculosis is a rare clinical condition in nonendemic countries and should be included as differential diagnosis by unspecific abdominal complaints, especially in patients with immigration background from high‐prevalence regions.