bluuebunny/crossref_metadata_2025_split huggingface dataset:
An analysis of indoor environment evaluation for The Springs development in Dubai, UAE
Authors: Jung Chuloh , Awad Jihad , Sami Abdelaziz Mahmoud Naglaa , Salameh Muna 
Published: June 2021

Purpose
This study aims to evaluate The Springs’ indoor environment, one of the iconic townhouse-type residential buildings in Dubai, more efficiently for the integrated evaluation of the indoor environment with the weights of indoor environmental factors such as thermal, indoor air, lighting and acoustic.

Design/methodology/approach
The weights of the indoor environment factors were derived for the integrated evaluation to reflect the residents’ preferences. Based on the post-occupancy evaluation (P.O.E.) survey, the weights according to the gender, age group and indoor spaces followed a comparison and analytical processes.

Findings
This paper had found the priority of residents’ needs for each space in The Springs project. In summer, thermal comfort was the most important factor for living room and the master bedroom. In winter, the priority for living room and kitchen was the indoor air quality.

Research limitations/implications
As it is the first research survey for housing project in Dubai, it needs to be extended to other housing projects in Dubai. To increase the reliability of the weights calculated through this study and the applicability of the integrated indoor environmental evaluation, more in-depth P.O.E. survey is needed with wide range of survey participants.

Social implications
This paper will help developing guidelines for future renovation based on the comparative analysis among thermal comfort, acoustic comfort, lighting comfort and indoor air comfort.

Originality/value
This paper is the first attempt to analyze the condition of early housing projects in Dubai. The data can be used to increase not only the design quality and marketability of housing projects in Dubai but also the condition of residents’ health status to avoid sick building syndrome from approximately 20 years old buildings.
A framework for digital preservation of Indigenous knowledge system (IKS) in repositories in South Africa
Authors: Balogun Tolulope , Kalusopa Trywell 
Published: June 2021

PurposeThe purpose of this study is to assess the digital preservation policies and plans for long-term digital preservation in selected repositories in South Africa, with a view to develop a digital preservation framework for the preservation of Indigenous knowledge system (IKS) in South Africa.Design/methodology/approachThrough the multiple case study research design, data was obtained from eight respondents in four Indigenous Knowledge Systems Documentation Centers (IKSDCs) in institutions that are part of the National Recordal Systems (NRS) initiative across four provinces in South Africa using in-depth face-to-face interviews. Data collected was also supplemented with the content analysis of several policy documents in South Africa.FindingsThe findings reveal that there are no digital preservation policies in place in the institutions, especially long-term digital preservation for IKS. However, some of the institutions are formulating policies that will include the management of IKS collected in the institutions. This study also reveals that digital curation, policy formulation and disaster preparedness plans to some extent are measures said to be in place for the digital preservation of IKS.Research limitations/implicationsThis study focuses mainly on the NRS initiative in South Africa. Indigenous Knowledge (IK) related to traditional medicine, traditional plants and food are currently being digitized at the IKSDCs by IK recorders. This study will help in ensuring that the South African Government’s effort and investment in digitizing IKS and making them accessible online is not wasted. This study will help mitigate the risk of damage and alteration over time, either deliberately or in error.Originality/valueThis study fills a gap in the literature on the digitization and digital preservation of IKS from the context of the NRS project in South Africa. Very few studies have been carried out on the digital preservation of IKS in Africa. This study also proposed a framework for the digital preservation of IKS in South Africa.
The experiences of children in custody: a story of survival
Authors: Day Anne-Marie 
Published: June 2021

Purpose
This paper aims to explore children’s experiences during their time in custody in England and Wales.

Design/methodology/approach
A total of 48 children were interviewed, as part of a wider study on children’s pathways into, through and out of custody. The focus of this paper is on children’s experiences in young offender institutions.

Findings
The findings from this study suggest that children’s behaviour during incarceration can be understood largely as strategies for surviving the hostile environment in which they find themselves.

Practical implications
This paper seeks to make a series of recommendations for practitioner and policymakers, based on the findings of this study.

Originality/value
The findings from this study suggest that children’s behaviour during incarceration can be understood largely as strategies for surviving the hostile environment in which they find themselves. This paper seeks to highlight specific elements of this environment and offers an insight into how they may impact upon a child's sense of self and place in the world.
Clinicopathological insight into self‐reported hair loss with no findings: How do we manage this enigmatic condition?
Authors: Kinoshita‐Ise Misaki , Fukuyama Masahiro , Ohyama Manabu 
Published: June 2021

AbstractPatients who complain of hair loss without any supportive findings can be encountered in daily practice. To provide insight into this embarrassing condition, we retrospectively reviewed medical charts of eight cases with self‐reported hair loss with no findings (SHLNOF). High frequency in middle aged women and concomitance of thyroid and gynecological problems were revealed. Four patients reported scalp dysesthesia/trichodynia. Two patients underwent scalp biopsy, both of which demonstrated increase in indeterminate hairs, suggesting mild hair miniaturization. Supportive medical consultation coupled with the presentation of clinical and trichoscopic images reassured the majority of the patients. These findings suggested that SHLNOF should not be disregarded simply as a misconception. A non‐biased and diligent workup should be conducted to better manage this enigmatic condition.
What is love? The complex relation between values and practice in Vanuatu
Authors: Bratrud Tom 
Published: June 2021

AbstractThe past decade has seen a renewed anthropological interest in values, morality, and ethics. This article engages with this field by demonstrating how values can be strategies as well as ideals, prone to destabilize social order and divide people precisely because they are thought to be shared. The concept of ‘love’, referring to everyday practices of concern and care for others, is a core value for living on Ahamb Island in Vanuatu. However, adherence to the same core value does not necessarily create an ordered social world. Analysing three ethnographic cases, one of them a dispute with fatal consequences, I propose a model for studying values that accommodates ambiguity by uniting the notion of shared social values with individual experience and strategy. A methodological argument is that it is crucial for anthropological studies of values to assess the context for people's shifting interpretations and articulations of value in practice.
Advancing leadership in Australasian emergency medicine: Taking stock and looking ahead
Authors: Rixon Andrew , Wilson Samuel , Judkins Simon , Bonning John , Skinner Clare , White Peter 
Published: June 2021

AbstractSince 2018, the Australasian College for Emergency Medicine has collaborated with the Swinburne University of Technology on a research project to understand and enhance the leadership capacity of emergency physicians, beginning with Australasian Directors of Emergency Medicine (DEMs). Over the last 3 years, this research programme has revealed the complexity of leadership in emergency medicine, illuminating the strengths and limitations of extant research and suggesting promising new directions for emergency medicine leadership and leadership development research. This programme has also shed new light on the knowledge, skills and abilities that DEMs need to develop to catalyse change in the systems where DEMs practice both medicine and leadership. We propose that an approach to leadership development that reflects the diversity of DEMs' leadership challenges and the complexity of leadership in emergency medicine would go a long way to enhancing the sophistication, effectiveness and impact of the leadership in emergency medicine.
Linking high‐performance work systems and employee well‐being: A multilevel examination of the roles of organisation‐based self‐esteem and departmental formalisation
Authors: Wang Honglei , Zhang Yejun , Wan Min (Maggie) 
Published: June 2021

AbstractPrior research has suggested that the relationship between high‐performance work systems (HPWS) and employee well‐being has been inconclusive, and particularly less is known about the underlying mechanisms and the boundary conditions between them. Integrating signalling theory with uncertainty reduction theory, we propose a cross‐level model linking department‐level HPWS to employee job burnout. Specifically, we propose the mediating role of organisation‐based self‐esteem (OBSE) in the effect of department HPWS on employee job burnout, as well as the moderating role of departmental formalisation. Using a sample of 366 employees and 60 managers from 60 departments, we found that department‐level HPWS was associated with reduced employee job burnout both directly and indirectly through OBSE. In addition, the mitigating influence of department‐level HPWS on employee job burnout was significant only when departmental formalisation was high. The findings of this study contribute to resolving the inconclusive relationship between HPWS and employee well‐being.
Unique phage–bacterium interplay in sponge holobionts from the southern Okinawa Trough hydrothermal vent
Authors: Zhou Kun , Qian Pei‐Yuan , Zhang Ting , Xu Ying , Zhang Rui 
Published: June 2021

SummaryDeep‐sea hydrothermal vents harbour diverse and abundant animals and their symbiotic microorganisms, which together comprise holobionts. The interplay between bacterial members of holobionts and their viruses (phages) is important for maintaining these symbiotic systems; however, phage–bacterium interactions in deep‐sea vent holobionts are not well understood. Marine sponges serve as good models for such studies and are used to unveil phage–bacterium interplay via metagenomic analysis. In three demosponges from deep‐sea hydrothermal vent fields in the southern Okinawa Trough, the genomes of a diverse array of symbiotic bacteria, including 10 bacterial phyla, were found to lack intact prophages. Genes related to diverse anti‐viral defence systems, for example, the restriction–modification and toxin–antitoxin systems, were abundant in the bacterial communities. We also detected phage genes that could complement or compensate host bacterial metabolism, indicating beneficial roles of phage infection. Our findings provide insight into phage–bacterium interplay in sponges from deep‐sea hydrothermal vents.
Neoantigen load as a prognostic and predictive marker for stage II/III non‐small cell lung cancer in Chinese patients
Authors: Gong Lei , He Ronghui , Xu Yanjun , Luo Taobo , Jin Kaixiu , Yuan Wuzhou , Zheng Zengguang , Liu Lanxuan , Liang Zebin , Li Ao , Zheng Zhiguo , Li Hui 
Published: June 2021

AbstractBackgroundThe prognosis for patients with stage II/III non–small cell lung cancer (NSCLC) is unsatisfactory, even after complete tumor resection and adjuvant chemotherapy. Here, we assessed the prognostic and predictive value of immunogenomic signatures for stage II/III NSCLC in Chinese patients.MethodsA total of 91 paired resected stage II/III NSCLC and normal tissues, including 47 squamous cell lung carcinomas (SCC) and 44 lung adenocarcinomas (ADC), were collected and analyzed using whole exome sequencing (WES) to identify immunogenomic signatures for association with clinicopathological variables and disease‐free survival (DFS).ResultsHigher neoantigen load (NAL, >2 neoantigens/Mb) exhibited better DFS for SCC patients (p = 0.021) but not ADC patients. A benefit from adjuvant chemotherapy was correlated with lower NAL (≤2 neoantigens/Mb) (p = 0.009). However, tumor mutation burden (TMB), mutations of individual gene, oncogene pathways, and antigen presentation machinery genes, and human leukocyte antigen (HLA)‐I number and HLA‐I loss of heterozygosity (LOH) had no prognostic or predictive value for DFS of SCC or ADC patients.ConclusionsNAL is a useful biomarker for lung SCC prognosis and prediction of chemotherapy responses in Chinese patients. The predictive value of NAL for adjuvant immunotherapy should be further explored in patients with resected NSCLC.
Circulating microRNA profile in humans and mice with congenital GH deficiency
Authors: Saccon Tatiana D. , Schneider Augusto , Marinho Cindi G. , Nunes Allancer D. C. , Noureddine Sarah , Dhahbi Joseph , Nunez Lopez Yury O. , LeMunyan Gage , Salvatori Roberto , Oliveira Carla R. P. , Oliveira‐Santos Alécia A. , Musi Nicolas , Bartke Andrzej , Aguiar‐Oliveira Manuel H. , Masternak Michal M. 
Published: June 2021

AbstractReduced inflammation, increased insulin sensitivity, and protection against cancer are shared between humans and mice with GH/IGF1 deficiency. Beyond hormone levels, miRNAs are important regulators of metabolic changes associated with healthy aging. We hypothesized that GH deficiency in humans alters the abundance of circulating miRNAs and that a subset of those miRNAs may overlap with those found in GH‐deficient mice. In this study, subjects with untreated congenital isolated GH deficiency (IGHD; n = 23) and control subjects matched by age and sex (n = 23) were recruited and serum was collected for miRNA sequencing. Serum miRNAs from young (6 month) and old (22 month) Ames dwarf (df/df) mice with GH deficiency and their WT littermates (n = 5/age/genotype group) were used for comparison. We observed 14 miRNAs regulated with a genotype by age effect and 19 miRNAs regulated with a genotype effect independent of age in serum of IGHD subjects. These regulated miRNAs are known for targeting pathways associated with longevity such as mTOR, insulin signaling, and FoxO. The aging function was overrepresented in IGHD individuals, mediated by hsa‐miR‐31, hsa‐miR‐146b, hsa‐miR‐30e, hsa‐miR‐100, hsa‐miR‐181b‐2, hsa‐miR‐195, and hsa‐miR‐181b‐1, which target the FoxO and mTOR pathways. Intriguingly, miR‐181b‐5p, miR‐361‐3p, miR‐144‐3p, and miR‐155‐5p were commonly regulated in the serum of humans and GH‐deficient mice. In vitro assays confirmed target genes for the main up‐regulated miRNAs, suggesting miRNAs regulated in IGHD individuals can regulate the expression of age‐related genes. These findings indicate that systemic miRNAs regulated in IGHD individuals target pathways involved in aging in both humans and mice.
Distribution and morphology of ventricular bands in the hearts of ringed seals
Authors: Laakkonen Juha 
Published: June 2021

AbstractIn contrast to studies on domestic animals, few reports describe ventricular bands in wildlife, and none in aquatic mammals. Ventricular bands in the endangered Saimaa ringed seal (Pusa hispida saimensis) and the Baltic ringed seal (Pusa hispida botnica) were examined as part of an ongoing research on the comparative anatomy of ringed seal subspecies. The dissections illustrated that a varying number of thin or thick ventricular bands from the papillary muscles to the ventricular walls were visible in the ventricles of all ringed seal specimens examined. The histological appearance of the ventricular bands was characterized by a fibromuscular pattern.
Botulinum toxin A (Botox) injection into muscles of pelvic floor as a treatment for persistent pelvic pain secondary to pelvic floor muscular spasm: A pilot study
Authors: Mooney Samantha S. , Readman Emma , Hiscock Richard J. , Francis Alaina , Fraser Elise , Ellett Lenore 
Published: June 2021

BackgroundPersistent pelvic pain (PPP) remains an important cause of morbidity. Pelvic floor muscle spasm is an important contributor to PPP.AimsThe study’s primary aim was to assess if botulinum toxin (BoNT) injection to pelvic floor muscles altered pain scores or quality of life (QoL) at six, 12 and 26 weeks. Secondary aims included investigating the impact of BoNT on opiate usage, examining the role of pain catastrophising, and assessing for complications.Materials and MethodsA single‐centre prospective cohort study enrolled 21 patients with PPP who had failed physiotherapy techniques. Each participant underwent BoNT injection to muscles of the pelvic floor and pudendal nerve block. Questionnaires and digital vaginal examinations were conducted at baseline, six, 12 and 26 weeks. Pain score quantification used visual analogue scales (VAS) and numerical rating scales (NRS). Other outcome assessments included The World Health Organization Quality of Life instrument (WHOQoL‐BREF), Pain Catastrophising Scale (PCS), and modified Australian Pelvic Floor Questionnaire (APFQ). ACTRN12620000067976.ResultsFollowing BoNT injection, median VAS scores decreased for all domains at six and 12 weeks, with VAS for dyspareunia significant at six weeks (P = 0.026). Scores returned to baseline by 26 weeks. Opiate usage was significantly less following BoNT injection, with a percentage reduction of 23.8% (95% CI −48.3 to 0.7, P = 0.06). Sexual function improved significantly (P < 0.01), and at six months, four previously apareunic participants reported successful penetrative vaginal intercourse. Health‐related QoL and PCS demonstrated sustained improvement (P = 0.02–0.05). NRS for muscle tenderness decreased for all assessed muscle groups (P < 0.001).ConclusionsBoNT requires further assessment as a treatment modality for select women with PPP.
Boosting the oral bioavailability of anticancer drugs through intentional drug–drug interactions
Authors: Eisenmann Eric D. , Talebi Zahra , Sparreboom Alex , Baker Sharyn D. 
Published: June 2021

AbstractOral anticancer drugs suffer from significant variability in pharmacokinetics and pharmacodynamics partially due to limited bioavailability. The limited bioavailability of anticancer drugs is due to both pharmaceutical limitations and physiological barriers. Pharmacokinetic boosting is a strategy to enhance the oral bioavailability of a therapeutic drug by inhibiting physiological barriers through an intentional drug–drug interaction (DDI). This type of strategy has proven effective across several therapeutic indications including anticancer treatment. Pharmacokinetic boosting could improve anticancer drugs lacking or with otherwise unacceptable oral formulations through logistic, economic, pharmacodynamic and pharmacokinetic benefits. Despite these benefits, pharmacokinetic boosting strategies could result in unintended DDIs and are only likely to benefit a limited number of targets. Highlighting this concern, pharmacokinetic boosting has mixed results depending on the boosted drug. While pharmacokinetic boosting did not significantly improve certain drugs, it has resulted in the commercial approval of boosted oral formulations for other drugs. Pharmacokinetic boosting to improve oral anticancer therapy is an expanding area of research that is likely to improve treatment options for cancer patients.
Exploring digital transformation through pretend play in kindergarten
Authors: Vogt Franziska , Hollenstein Lena 
Published: June 2021

AbstractDigitalisation and the accompanying transformation processes, involving data, technology and people, are part of children's life and will shape their future. Competences, such as digital skills, as well as creativity, communication, collaboration, critical thinking and problem solving are crucial to these transformation processes. In early childhood, these competences are essentially acquired through play, especially pretend play. The project ‘we play the future’ draws on the potential of pretend play to enable young children to be actively engaged in imagining themselves shaping digital transformation in the roles of inventors, developers and users. Drawing on an analysis of fields currently undergoing digital transformation, eight inputs for pretend play were developed to areas of digital transformation (eg, robotics, autonomous vehicles and Internet of things). Fifteen kindergarten teachers implemented the pretend play on digital transformation in their kindergarten after taking a half‐day introductory professional development course. The children's play was filmed and analysed using qualitative multimodal interaction analysis in order to examine the ways in which the pretend play encourages the exploration of digital transformation amongst the children. The results reveal the potential of pretend play for children to explore digital transformation and to acquire the digital competences needed in the future.
Practitioner notesWhat is already known about this topic?

Children integrate imaginative digital technology in their play.
Guided pretend play is important for children's learning in kindergarten.
What this paper adds

Ideas for pretend play in kindergarten to enable children developing an understanding of digital transformation in a playful way
The paper presents findings from video analysis which indicate that children are using competences needed for the digital future during pretend play
Implications for practice

Digital education should not just be focused on using and programming digital devices but include pretend play to explore digital transformation; through the inputs for pretend play suggested in the project, the kindergarten teachers support the children developing an understanding of digital technology.
The inputs for pretend play enable children to develop competences such as technical and digital skills, as well as creativity, communication, collaboration, critical thinking and problem solving.
Fine‐tuning multiciliated cell differentiation at the post‐transcriptional level: contribution of miR‐34/449 family members
Authors: Loukas Ioannis , Skamnelou Margarita , Tsaridou Stavroula , Bournaka Spyridoula , Grigoriadis Sokratis , Taraviras Stavros , Lygerou Zoi , Arbi Marina 
Published: June 2021

ABSTRACTCell differentiation is a process that must be precisely regulated for the maintenance of tissue homeostasis. Differentiation towards a multiciliated cell fate is characterized by well‐defined stages, where a transcriptional cascade is activated leading to the formation of multiple centrioles and cilia. Centrioles migrate and dock to the apical cell surface and, acting as basal bodies, give rise to multiple motile cilia. The concerted movement of cilia ensures directional fluid flow across epithelia and defects either in their number or structure can lead to disease phenotypes. Micro‐RNAs (miRNAs; miRs) are small, non‐coding RNA molecules that play an important role in post‐transcriptional regulation of gene expression. miR‐34b/c and miR‐449a/b/c specifically function throughout the differentiation of multiciliated cells, fine‐tuning the expression of many different centriole‐ and cilia‐related genes. They strictly regulate the expression levels of genes that are required both for commitment towards the multiciliated cell fate (e.g. Notch) and for the establishment and maintenance of this fate by regulating the expression of transcription factors and structural components of the pathway. Herein we review miR‐34 and miR‐449 spatiotemporal regulation along with their roles during the different stages of multiciliogenesis.