bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectrum of hemoglobin disorders in southern Odisha, India: a hospital based study
Authors: Sahu Pramita , Purohit Prasanta , Mantri Santwana , Tudu Ramray , Nayak Jayanti , Agrawalla Sunil Kumar , Behera Samira Kumar , Patro Manoj Kumar , Karmee Nivedita , Tripathy Diptimayee , Mishra Bharati , Mishra Debi Prasad 
Published: February 2021

Abstract

Background:
Hemoglobin disorders are the leading health concern in the world including India. There is a paucity of literature on the spectrum of hemoglobin disorders in southern districts of Odisha state. This study was undertaken to elucidate the occurrence of different hemoglobin disorders in a tertiary health care facility of Odisha state, India.

Methods:
The study cases were suspected patients of all age groups advised for screening of different hemoglobin disorders. Hemoglobin disorders were screened by sickling slide test and high-performance liquid chromatography (HPLC) using the Variant-II hemoglobin testing system as per the manufacturer's guidelines.

Results:
Over 2 years, 2332 blood samples (including 1102 pediatric and 1230 adult cases) were investigated, out of which, 1380 (59.2%) of cases had abnormal hemoglobin disorders. The most common was sickle cell disorders (48.67%, 1135/2332) followed by β-thalassemia (11.32%, 264/2332). Some rare variants were detected as hemoglobin D-Punjab, hemoglobin E, hemoglobin Lepore, hereditary persistence of fetal hemoglobin, hemoglobin with high P2 window, hemoglobin with high P3 window etc, Among the cases with abnormal hemoglobin disorders, 744 (53.9%), 545 (39.5%) and, 91 (6.6%) cases were found to have the heterozygous, homozygous and, double heterozygous state. Of the 188 ante-natal cases screened, 31.4% of cases had abnormal hemoglobin variants with sickle cell disorders being the most prevalent one.

Conclusion:
Along with the high occurrence of sickle cell disorders in the study area, some other rare hemoglobin disorders are also prevalent which calls for a large community-based cohort study.
What is the clinical evidence on psilocybin for the treatment of psychiatric disorders? A systematic review
Authors: Castro Santos Henrique , Gama Marques João 
Published: February 2021

Abstract

Background:
Psilocybin is a predominant agonist of 5HT1A and 5HT2A/C receptors and was first isolated in 1958, shortly before it became a controlled substance. Research on the potential therapeutic effects of this compound has recently re-emerged alongside what is being addressed as a psychedelic renaissance.

Methods:
In this paper we performed a systematic review of the clinical trials conducted so far regarding the therapeutic effects of psilocybin on psychiatric disorders. The eligibility criteria included clinical trials that assessed psilocybin's potential therapeutic effects on patients with psychiatric disorders. Nine hundred seven articles were found and screened in regard to the title, from which 94 were screened through abstract and 9 met the eligibility criteria and were included.

Results:
The papers published focused on 3 disorders: depression, obsessive-compulsive disorder (OCD) and substance use disorder (namely tobacco and alcohol). Psilocybin has shown a relatively safe profile and very promising results, with reductions found on most of the psychiatric rating scales’ scores. Research on depression showed the most solid evidence, supported by 3 randomized controlled trials. Studies on OCD and substance use disorder showed more limitations due to their open-label design.

Conclusions:
Altogether, the results from the studies reviewed in this paper suggest a substantial therapeutic potential. This calls for further research to confirm the results observed so far and further explain the underlying mechanisms.
Moderation of doxorubicin-induced nephrotoxicity in Wistar rats by aqueous leaf-extracts of Chromolaena odorata and Tridax procumbens
Authors: Ikewuchi Catherine C. , Ifeanacho Mercy O. , Ikewuchi Jude C. 
Published: February 2021

Abstract

Background:
The major draw-back of doxorubicin's use in chemotherapy is its toxicity on various organs including the kidneys. This study investigated the potential protective role of aqueous leaf-extracts of Chromolaena odorata and Tridax procumbens against nephrotoxicity induced by doxorubicin.

Methods:
To this end, their impact on plasma biomarkers of kidney function, as well as renal lipid profile, biomarkers of oxidative stress, electrolyte profile and activities of renal ATPases was monitored in doxorubicin treated rats. Metformin (250 mg/kg body weight, orally) and the extracts (50, 75 and 100 mg/kg, orally) were daily administered for 14 days; while nephrotoxicity was induced with doxorubicin (15 mg/kg, intra-peritioneally), once on the 12th day of study.

Results:
The plasma concentrations of creatinine, and urea; as well as the renal malondialdehyde, cholesterol, calcium and sodium concentrations in the Test control, were significantly (P < .05) higher than those of all the other groups. However, the renal concentrations of ascorbic acid, chloride, magnesium and potassium, and the renal activities of catalase, glutathione peroxidase superoxide dismutase, Ca2+-ATPase, Mg2+-ATPase and Na+,K+-ATPase in the Test control were significantly (P < .05) lower than those of all the other groups.

Conclusions:
Pre-treatment with the extracts and metformin boosted endogenous antioxidants, and prevented doxorubicin-induced renal damage, as indicated by the attenuation of doxorubicin-induced renal oxidative stress, as well as the attenuation of doxorubicin-induced adverse alterations in renal cholesterol, ATPases and electrolyte balance, and plasma biomarkers of kidney function, and keeping them at near-normal values.
Assessment of coping with cancer-related burdens: psychometric properties of the Cognitive-Emotional Coping with Cancer scale and the German Mini-mental Adjustment to Cancer scale
Authors: Cwik Jan C. , Vaganian Lusine , Bussmann Sonja , Labouvie Hildegard , Houwaart Stefanie , Gerlach Alexander L. , Kusch Michael 
Published: February 2021

Abstract

Objective:
A proportion of cancer patients develop depression and anxiety as a consequence of the cancer diagnosis. The common-sense model of self-regulation is a theoretical framework focusing on cognitive-emotional processes that can explain associations between cancer and depression and anxiety. Based on this model, we constructed the Cognitive-Emotional Coping with Cancer scale (CECC) and assessed its psychometric properties. A secondary aim was to test the factorial structure of the German version of the Mini-Mental Adjustment to Cancer Scale (Mini-MAC).

Methods:
Overall, 412 participants with a current cancer diagnosis or a cancer diagnosis in remission were included in an online survey study. The factorial structure of the CECC was studied via exploratory analysis, and the factorial structure of the German Mini-MAC was via a confirmatory factorial analysis. The construct validity of both scales was also investigated with multi-trait/multi-method analyses. The cutoff scores, internal consistency, and test-reliability of the CECC subscales were calculated.

Results:
The results illustrated that the CECC consists of 5 correlating subscales. These subscales had a very good construct validity and reliability. The construct validity of the Mini-MAC was good, and the confirmatory factorial analysis showed an adequate model fit of the 5-factor model. However, the internal consistency and the factor loading of 2 subscales of the German Mini-MAC are questionable.

Conclusions:
The CECC can be a useful tool to assess cognitive-emotional strategies to cope with cancer for researchers and practitioners. For the German Mini-MAC, the study confirmed factorial structures with questionable psychometric properties of 2 subscales.
Preemptive VAE—An Important Tool for Managing Blood Loss in MVT Candidates With PMT
Authors: Borle Deeplaxmi P. , Kesseli Samuel J. , Barbas Andrew S. , Rege Aparna S. , Vikraman Deepak , Kadiyala Ravindra , Kim Charles Y. , Smith Tony P. , Suhocki Paul V. , Sudan Debra L. 
Published: February 2021

Background.
Explantation of native viscera in multivisceral transplant candidates, particularly in those with extensive portomesenteric thrombosis (PMT), carries considerable morbidity due to extensive vascularized adhesions. Preemptive visceral angioembolization has been previously described as a technique to minimize excessive blood loss during mobilization of the native viscera but is not well described specifically in patients with extensive PMT.

Methods.
In a series of 5 patients who underwent mutivisceral transplant for PMT from June 2015 to November 2018, we performed preoperative superior mesenteric, splenic, and hepatic artery embolization to reduce blood loss during explanation and evaluated the blood loss and blood product utilization, as well as 30-day rates of infectious complications.

Results.
Following preemptive embolization, median total blood loss was 6000 mL (range 800–7000 mL). The median transfusion requirements were as follows: 16 units packed red blood cells (range 2–47), 14 units fresh frozen plasma (range 0–29), 2 units cryoprecipitate (range 1–14), 4 units platelets (range 2–10), and 500 mL cell saver autotransfusion (range 0–1817). In the first 30 postoperative days, 2 out of 5 patients developed positive blood cultures and 3 out of 5 developed complex intra-abdominal infections. Two patients developed severe graft pancreatitis resulting in mycotic aneurysm of the aortic conduit; bleeding from the aneurysm led to 1 patient mortality.

Conclusions.
Preoperative embolization is an effective modality to mitigate exsanguinating blood loss during multivisceral transplant in patients with portomesenteric thrombosis; however, it is unclear if the resultant native organ ischemia during explant carries clinically relevant consequences.
Structural Basis for SARS-CoV-2 Envelope Protein in Recognition of Human Cell Junction Protein PALS1
Authors: Chai Jin , Cai Yuanheng , Pang Changxu , Wang Liguo , McSweeney Sean , Shanklin John , Liu Qun 
Published: February 2021

AbstractThe COVID-19 pandemic caused by the SARS-CoV-2 virus has created a global health and economic emergency. SARS-CoV-2 viruses hijack human proteins to promote their spread and virulence including the interactions involving the viral envelope (E) protein and human proteins. To understand the structural basis for SARS-CoV-2 viral-host recognition, we used cryo-electron microscopy to determine a structure for the human cell junction protein PALS1 and SARS-CoV-2 E protein complex. The structure shows that the E protein C-terminal DLLV motif recognizes a pocket formed exclusively by hydrophobic residues from the PDZ and SH3 domains in PALS1. Our structural analysis provides an explanation for the observation that the viral E protein recruits PALS1 from lung epithelial cell junctions resulting in vascular leakage, lung damage, viral spread, and virulence. In addition, our structure provides novel targets for peptide- and small-molecule inhibitors that could block the PALS1-E interactions to reduce the E-mediated damage to vascular structures.
p97/VCP induces GLI1 to control XBP1-dependent endoplasmic reticulum stress transcriptional response
Authors: Barroso Kim , Almada Luciana L. , Olson Rachel L. O. , Auner Holger W. , Pedeux Rémy , Iovanna Juan L. , Chevet Eric , Fernandez-Zapico Martin E. 
Published: February 2021

AbstractUpon accumulation of improperly folded proteins in the ER, an adaptive pathway named the UPR is triggered to restore ER homeostasis. The induction of stress genes controlling ER dynamics is a conditionsine qua nonfor an effective UPR. Although this requirement has been extensively characterized, the transcriptional mechanism underlying this process remains in part elucidated. Here, we show that p97/VCP, an AAA+ ATPase known to modulate ER stress-induced gene expression, dynamically interacts with RUVBL2 and the mSin3A-HDAC1/2 complex. Further analysis of the mechanism defined a novel interplay between the aforementioned molecules and the transcription factor USF2 to control expression of GLI1, a primary effector of Hedgehog (Hh) signaling. Under basal conditions, GLI1 is repressed by RUVBL2-mSin3A-HDAC1/2 while upon ER stress GLI1 is induced through a mechanism requiring p97/VCP-mediated extraction of the repressor complex. Further analysis showed that GLI1 cooperate with ATF6f to activate the expression of XBP1, a transcription factor regulating the expression of genes controlling cellular stress response, under ER conditions. Overall, our work demonstrates that p97/VCP orchestrates the activation of GLI1 upon ER stress in a Hh ligand-independent fashion and defines the interplay between the newly identified p97/VCP-mSin3A-HDAC1/2 complex and the transcription factor USF2 as an essential player in this process.
Investigating tourist post-travel evaluation and behavioural intention: a cultural intelligence perspective
Authors: Zhang Yunen , Shao Wei , Thaichon Park 
Published: February 2021

PurposeThis paper aims to investigate whether cultural intelligence will influence Chinese tourists’ travel satisfaction, revisit intention and word-of-mouth communication.Design/methodology/approachAn online survey was conducted to collect data from 614 adult Chinese tourists, who have overseas travel experiences. Then, the Statistics Package for the Social Sciences (SPSS) and the structural equation modelling (SEM) were employed for data analysis.FindingsThe findings confirm that cultural intelligence has significant positive impacts on tourist satisfaction, revisit intention and electronic word-of-mouth (eWOM) communication. Additionally, tourist satisfaction significantly affects tourist eWOM communication.Originality/valueThis study provides theoretical and practical contributions regarding the effects of tourist cultural intelligence, especially on tourist post-travel evaluation and behavioural intention, which has been merely investigated in extant tourism research.
Optimum investor portfolio allocation in new age digital assets
Authors: Aggarwal Vaibhav 
Published: February 2021

Purpose
Bitcoin and Ethereum, although the most prominent cryptocurrencies, carry a high ticker price. Many investors carry an inherent bias against high price ticker securities and prefer only low prices securities. This paper aims to help market players generate adequate risk-adjusted returns by investing in only lower-priced cryptocurrencies.

Design/methodology/approach
The pairwise bivariate BEKK-GARCH (1,1) model is deployed to capture the short- and long-term volatility linkages between Litecoin, Stellar and Ripple from August 2015 to June 2020.

Findings
Litecoin is the most influential volatility sender in the basket of these three cryptocurrencies. The portfolio weights indicate that investors can create an optimized two asset portfolio with the lowest exposure to Stellar with Litecoin and Ripple. Market players with a long position in Ripple can have the cheapest hedge by shorting Stellar.

Originality/value
This study adds to the scant literature on the association between emerging cryptocurrencies and finding optimum portfolio weight and hedge ratios.
The role of digitalized information sharing for flexibility capability utilization: lessons from Germany and Japan
Authors: Doetzer Mathias , Pflaum Alexander 
Published: February 2021

PurposeInformation-sharing and flexibility are considered to be major tools for risk mitigation and supply chain resiliency. However, less light has been shed on the role of information-sharing as an enabler to utilize flexibility capabilities before and after supply chain disruptions. The aim of this paper is to provide indications on how digitalized information-sharing (DIS) enhances flexibility capability utilization.Design/methodology/approachThe methodology follows a qualitative approach, including 31 transcribed semi-structured interviews with supply chain experts in Germany and Japan.FindingsThe findings indicate that DIS supports flexibility capability utilization in pre- and post-disruptive supply chain management. First, the enhancement of estimated transport time accuracy supports rapid supplier and transport mode adjustment. Second, while the effects of DIS in manufacturing are limited without pre-existing flexibility capabilities, steady internal and external DIS utilizes exciting manufacturing flexibility to cope with disruptions beyond production. Third, track and trace technologies enhance the value of shared data and allow flexibility in the form of demand-oriented distribution, but companies unable to adopt technologies can still enhance flexibility capabilities with DIS using the existing infrastructure.Originality/valueThis paper highlights the essential role of digital information-sharing for flexibility utilization in supply chain risk management. While existing studies engaged with flexibility and information-sharing in supply chain risk management, this study contributes by emphasizing digital information-sharing as a key triggering enabler for flexibility in pre- and post-disruptive phases.
Prudence and temperance in portfolio selection with Shariah-compliant investments
Authors: Mounir Amine Mohammed 
Published: February 2021

Purpose
This paper aims to explore the impact of Sharīʿah-compliant stocks on other investor risk preferences beyond the risk aversion, namely, prudence and temperance.

Design/methodology/approach
This paper uses the non-parametric model data envelopment analysis with the shortage function as a measure of performance. The model uses three specifications considering skewness and kurtosis that describe according to expected utility theory, prudence and temperance.

Findings
Results show that first, efficient portfolios consist mainly of conventional stocks in the three-model specification. Second, the skewness improvement is achieved only when considering conventional stocks while Sharīʿah-compliant assets do not exhibit any impact on the third moment. Finally, diversification through both conventional and Sharīʿah-compliant stocks does not lead to kurtosis reduction. Sharīʿah-compliant stocks in efficient portfolios are sensitive to return and risk solely, and hence, prudence and temperance as related to skewness and kurtosis measures can be ignored in optimal portfolio selection during normal market conditions.

Research limitations/implications
Findings suggest the same conclusions for four Islamic screening methods; however, readers should be prudent due to the limited sample. Results show that Sharīʿah-compliant assets do not have an impact on higher-order moments optimal portfolio returns, and hence, question the commonly admitted assumption of non-normality return distributions at least for Sharīʿah-compliant stocks.

Practical implications
The research findings suggest that Islamic investor preferences are described only by return and risk along with Sharīʿah criteria for stock selection and portfolio allocation. Portfolio managers should not care about higher-order moments to manage Sharīʿah-compliant funds. The traditional mean-variance Markowitz framework will be sufficient for investment or allocation decision-making. Description of Sharīʿah-compliant portfolio returns with only the first two order moments gives such asset more resiliency to extreme events like a crisis.

Originality/value
This research is the first in literature exploring whether prudence and temperance defined by higher-order moments can be drivers, besides Sharīʿah criteria, in portfolio allocation decision-making. This study is unique in terms of methodology and application. It uses individual stock data on the Casablanca Stock Exchange.
A comparative analysis of the provision of student housing safety measures
Authors: Simpeh Fredrick , Akinlolu Mariam 
Published: February 2021

PurposeSecurity, safety, environment and health have become an integral part of facility management (FM). Therefore, FM departments within organisations are required to put measures in place to safeguard facility users. This paper thus aims to investigate and compare the safety and security measures that are provided in the student housing of two universities in South Africa.Design/methodology/approachA mixed method approach was adopted; interview was used to collect qualitative data, whereas a questionnaire was used as an instrument to collect quantitative data. Content analysis was used to analyse the qualitative data, whereas both descriptive and inferential statistics were used to analyse the quantitative data.FindingsIt became evident that university B had a better provision of safety and security measures in the student housing than university A. The study also found that both universities had some lapses in the safety and security measures provided in the student housing. Measures that were lacking in both universities were weapon detector, closed-circuit television (CCTV), water sprinkler system, burglar bars on the doors, lift for disabled students, disabled toilet facility, traffic light, tags for vehicles, first aid box, accident book and medically trained personnel.Research limitations/implicationsData were collected from only two universities, making it difficult to generalise the findings of the research. For a broader perspective, a study that expands the number of participating universities is recommended.Practical implicationsThe facility management and safety department in the universities can use the recommendations to improve on the safety and security measures required in the student housing. Moreover, the recommendations can contribute to the development of policy frameworks for student housing safety.Originality/valueThere is a paucity of studies on student housing safety/security worldwide, and South Africa in particular. With this study, the authors contribute to the body of knowledge in this area of research.
The four spheres of value co-creation in humanitarian professional services
Authors: Pillitteri Francesco , Mazzola Erica , Bruccoleri Manfredi 
Published: February 2021

PurposeThe study focuses on the value co-creation processes in humanitarian professional services provision, analysing the key enabling factors of beneficiaries' participation, involved in long-term integration programmes (L-TIPs).Design/methodology/approachThrough an in-depth case study, the research looks at the practices of value co-creation in humanitarian professional services, considering both the perspectives of the professional service provider and beneficiary.FindingsIn professional services beneficiary's participation affects the success of the L-TIPs outcomes. Participation's enablers can be classified into four different spheres, each belonging to different elements of professional service: the beneficiary, the professionals, the service design and the external environment.Research limitations/implicationsThis paper contributes to the literature on humanitarian operations & supply chain management. By focussing on an understudied phase of the disaster life-cycle management, it contributes to the theory of value co-creation by exploring new issues and drivers of beneficiary's participation.Practical implicationsThis research has interesting implications for policymakers and humanitarian practitioners. First, guidelines for professionals' behaviours and interventions should be designed as well as new practices and strategies should be adopted. Second, governments should avoid concentrating L-TIPs in few big humanitarian centres.Originality/valueThe study focuses on an understudied stage of humanitarian operations, namely the L-TIPs, and uses this setting to build on the theory of value co-creation in professional services by identifying its enabling factors, clustered into four spheres, namely beneficiary, professional, service design and environmental.