bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of movement sonification on haptic perception changes with aging
Authors: Landelle C. , Danna J. , Nazarian B. , Amberg M. , Giraud F. , Pruvost L. , Kronland-Martinet R. , Ystad S. , Aramaki M. , Kavounoudias Anne 
Published: March 2021

AbstractCombining multisensory sources is crucial to interact with our environment, especially for older people who are facing sensory declines. Here, we examined the influence of textured sounds on haptic exploration of artificial textures in healthy younger and older adults by combining a tactile device (ultrasonic display) with synthetized textured sounds. Participants had to discriminate simulated textures with their right index while they were distracted by three disturbing, more or less textured sounds. These sounds were presented as a real-time auditory feedback based on finger movement sonification and thus gave the sensation that the sounds were produced by the haptic exploration. Finger movement velocity increased across both groups in presence of textured sounds (Rubbing or Squeaking) compared to a non-textured (Neutral) sound. While young adults had the same discrimination threshold, regardless of the sound added, the older adults were more disturbed by the presence of the textured sounds with respect to the Neutral sound. Overall, these findings suggest that irrelevant auditory information was taken into account by all participants, but was appropriately segregated from tactile information by young adults. Older adults failed to segregate auditory information, supporting the hypothesis of general facilitation of multisensory integration with aging.
Multinuclear MRI to disentangle intracellular sodium concentration and extracellular volume fraction in breast cancer
Authors: Ianniello Carlotta , Moy Linda , Fogarty Justin , Schnabel Freya , Adams Sylvia , Axelrod Deborah , Axel Leon , Brown Ryan , Madelin Guillaume 
Published: March 2021

AbstractThe purpose of this work was to develop a novel method to disentangle the intra- and extracellular components of the total sodium concentration (TSC) in breast cancer from a combination of proton ($$^{1}$$

1

H) and sodium ($$^{23}\hbox {Na}$$

23

Na

) magnetic resonance imaging (MRI) measurements. To do so, TSC is expressed as function of the intracellular sodium concentration ($$\hbox {C}_{\text {IC}}$$

C
IC

), extracellular volume fraction (ECV) and the water fraction (WF) based on a three-compartment model of the tissue. TSC is measured from $$^{23}\hbox {Na}$$

23

Na

MRI, ECV is calculated from baseline and post-contrast $$^{1}$$

1

H $$\hbox {T}_{{1}}$$

T
1

maps, while WF is measured with a $$^{1}$$

1

H chemical shift technique. $$\hbox {C}_{\text {IC}}$$

C
IC

is then extrapolated from the model. Proof-of-concept was demonstrated in three healthy subjects and two patients with triple negative breast cancer. In both patients, TSC was two to threefold higher in the tumor than in normal tissue. This alteration mainly resulted from increased $$\hbox {C}_{\text {IC}}$$

C
IC

($$\sim$$
∼
30 mM), which was $$\sim$$
∼
130% greater than in healthy conditions (10–15 mM) while the ECV was within the expected range of physiological values (0.2–0.25). Multinuclear MRI shows promise for disentangling $$\hbox {C}_{\text {IC}}$$

C
IC

and ECV by taking advantage of complementary $$^{1}$$

1

H and $$^{23}\hbox {Na}$$

23

Na

measurements.
Masks and distancing during COVID-19: a causal framework for imputing value to public-health interventions
Authors: Babino Andres , Magnasco Marcelo O. 
Published: March 2021

AbstractDuring the COVID-19 pandemic, the scientific community developed predictive models to evaluate potential governmental interventions. However, the analysis of the effects these interventions had is less advanced. Here, we propose a data-driven framework to assess these effects retrospectively. We use a regularized regression to find a parsimonious model that fits the data with the least changes in the $$R_t$$

R
t

parameter. Then, we postulate each jump in $$R_t$$

R
t

as the effect of an intervention. Following the do-operator prescriptions, we simulate the counterfactual case by forcing $$R_t$$

R
t

to stay at the pre-jump value. We then attribute a value to the intervention from the difference between true evolution and simulated counterfactual. We show that the recommendation to use facemasks for all activities would reduce the number of cases by 200,000 ($$95\%$$

95
%

CI 190,000–210,000) in Connecticut, Massachusetts, and New York State. The framework presented here might be used in any case where cause and effects are sparse in time.
Quantifying genetic heterogeneity between continental populations for human height and body mass index
Authors: Guo Jing , Bakshi Andrew , Wang Ying , Jiang Longda , Yengo Loic , Goddard Michael E. , Visscher Peter M. , Yang Jian 
Published: March 2021

AbstractGenome-wide association studies (GWAS) in samples of European ancestry have identified thousands of genetic variants associated with complex traits in humans. However, it remains largely unclear whether these associations can be used in non-European populations. Here, we seek to quantify the proportion of genetic variation for a complex trait shared between continental populations. We estimated the between-population correlation of genetic effects at all SNPs ($$r_{g}$$

r
g

) or genome-wide significant SNPs ($$r_{{g\left( {GWS} \right)}}$$

r

g

GWS

) for height and body mass index (BMI) in samples of European (EUR; $$n = 49,839$$

n
=
49
,
839

) and African (AFR; $$n = 17,426$$

n
=
17
,
426

) ancestry. The $$\hat{r}_{g}$$

r
^

g

between EUR and AFR was 0.75 ($${\text{s}}.{\text{e}}. = 0.035$$

s
.
e
.
=
0.035

) for height and 0.68 ($${\text{s}}.{\text{e}}. = 0.062$$

s
.
e
.
=
0.062

) for BMI, and the corresponding $$\hat{r}_{{g\left( {GWS} \right)}}$$

r
^

g

GWS

was 0.82 ($${\text{s}}.{\text{e}}. = 0.030$$

s
.
e
.
=
0.030

) for height and 0.87 ($${\text{s}}.{\text{e}}. = 0.064$$

s
.
e
.
=
0.064

) for BMI, suggesting that a large proportion of GWAS findings discovered in Europeans are likely applicable to non-Europeans for height and BMI. There was no evidence that $$\hat{r}_{g}$$

r
^

g

differs in SNP groups with different levels of between-population difference in allele frequency or linkage disequilibrium, which, however, can be due to the lack of power.
A prospective cohort register-based study of chronic postsurgical pain and long-term use of pain medication after otorhinolaryngological surgery
Authors: Graf Nina , Geißler Katharina , Meißner Winfried , Guntinas-Lichius Orlando 
Published: March 2021

AbstractData on chronic postsurgical pain (CPSP) after otorhinolaryngological surgery are sparse. Adult in-patients treated in 2017 were included into the prospective PAIN OUT registry. Patients’ pain on the first postoperative day (D1), after six months (M6) and 12 months (M12) were evaluated. Determining factor for CPSP was an average pain intensity ≥ 3 (numeric rating scale 0–10) at M6. Risk factors associated with CPSP were evaluated by univariate and multivariate analyses. 10% of 191 included patients (60% male, median age: 52 years; maximal pain at D1: 3.5 ± 2.7), had CPSP. Average pain at M6 was 0.1 ± 0.5 for patients without CPSP and 4.2 ± 1.2 with CPSP. Average pain with CPSP still was 3.7 ± 1.1 at M12. Higher ASA status (Odds ratio [OR] = 4.052; 95% confidence interval [CI] = 1.453–11.189; p = 0.007), and higher minimal pain at D1 (OR = 1.721; CI = 1.189–2.492; p = 0.004) were independent predictors of CPSP at M6. Minimal pain at D1 (OR = 1.443; CI = 1.008–2.064; p = 0.045) and maximal pain at M6 (OR = 1.665; CI = 1.340–2.069; p < 0.001) were independent predictors for CPSP at M12. CPSP is an important issue after otorhinolaryngological surgery. Better instrument for perioperative assessment should be defined to identify patients at risk for CPSP.
Prolonged cetuximab treatment promotes p27Kip1-mediated G1 arrest and autophagy in head and neck squamous cell carcinoma
Authors: Okuyama Kohei , Suzuki Keiji , Naruse Tomofumi , Tsuchihashi Hiroki , Yanamoto Souichi , Kaida Atsushi , Miura Masahiko , Umeda Masahiro , Yamashita Shunichi 
Published: March 2021

AbstractCetuximab, an anti-epidermal growth factor receptor (EGFR) monoclonal antibody, is an efficient anti-tumor therapeutic agent that inhibits the activation of EGFR; however, data related to the cellular effects of prolonged cetuximab treatment are limited. In this study, the long-term cellular outcome of prolonged cetuximab treatment and the related molecular mechanism were explored in a head and neck squamous cell carcinoma cell line constitutively expressing a fluorescent ubiquitination-based cell cycle indicator. Fluorescent time-lapse imaging was used to assess clonal growth, cell motility, and cell-cycle progression. Western blot analysis was performed to measure the level of phosphorylation and protein-expression following cetuximab treatment. Over 5 days cetuximab treatment decreased cell motility and enhanced G1 phase cell arrest in the central region of the colonies. Significantly decreased phosphorylation of retinoblastoma, Skp2, and Akt-mTOR proteins, accumulation of p27Kip1, and induction of type II LC3B were observed over 8 days cetuximab treatment. Results of the present study elucidate the cetuximab-dependent inhibition of cell migration, resulting in high cell density-related stress and persistent cell-cycle arrest at G1 phase culminating in autophagy. These findings provide novel molecular insights related to the anti-tumor effects of prolonged cetuximab treatment with the potential to improve future therapeutic strategy.
Ultra-broadband, lithography-free, omnidirectional, and polarization-insensitive perfect absorber
Authors: Chen Tse-An , Yub Meng-Ju , Lu Yu-Jung , Yen Ta-Jen 
Published: March 2021

AbstractPerfect absorbers (PAs) at near infrared allow various applications such as biosensors, nonlinear optics, color filters, thermal emitters and so on. These PAs, enabled by plasmonic resonance, are typically powerful and compact, but confront inherent challenges of narrow bandwidth, polarization dependence, and limited incident angles as well as requires using expensive lithographic process, which limit their practical applications and mass production. In this work, we demonstrate a non-resonant PA that is comprised of six continuous layers of magnesium fluoride (MgF2) and chromium (Cr) in turns. Our device absorbs more than 90% of light in a broad range of 900–1900 nm. In addition, such a planar design is lithography-free, certainly independent with polarization, and presents a further advantage of wide incidence up to 70°. The measured performance of our optimized PA agrees well with analytical calculations of transfer matrix method (TMM) and numerical simulations of finite element method, and can be readily implemented for practical applications.
Immunomodulatory nanomedicine for colorectal cancer treatment: a landscape to be explored?
Authors: Silveira Maria José , Castro Flávia , Oliveira Maria José , Sarmento Bruno 
Published: March 2021

Immunomodulatory nanomedicine has the potential to modulate CRC tumors with distinct associated immune cells, leading to the recruitment and activation of the immune populations, which will further, recognize tumor cells and allow its elimination.
Wideband Acoustic Reflex Growth in Adults With Cystic Fibrosis
Authors: Westman Martha R. , Putterman Daniel B. , Garinis Angela C. , Hunter Lisa L. , Feeney M. Patrick 
Published: March 2021

Purpose
Individuals with cystic fibrosis (CF) are often treated with intravenous (IV) aminoglycoside (AG) antibiotics to manage life-threatening bacterial infections. Preclinical animal data suggest that, in addition to damaging cochlear hair cells, this class of antibiotics may cause cochlear synaptopathy and/or damage to higher auditory structures. The acoustic reflex growth function (ARGF) is a noninvasive, objective measure of neural function in the auditory system. A shallow ARGF (small reflex-induced changes in middle ear function with increasing elicitor level) has been associated with synaptopathy due to noise exposure in rodent and human studies. In this study, the ARGF was obtained in CF patients with normal hearing, some of whom have been treated with IV AGs, and a control group without CF. The hypothesis was that patients with IV-AG exposure would have a shallow ARGF due to cochlear synaptopathy caused by ototoxicity.

Method
Wideband ARGFs were examined in four groups of normal-hearing participants: a control group of 29 individuals without CF; and in 57 individuals with CF grouped by lifetime IV-AG exposure: 15 participants with no exposure, 21 with low exposure, and 21 with high exposure. Procedures included pure-tone audiometry, clinical immittance, wideband acoustic immittance battery, including ARGFs, and transient evoked otoacoustic emissions.

Results
CF subjects with normal pure-tone thresholds and either high or low lifetime IV-AG exposure had enhanced ARGFs compared to controls and CF participants without IV-AG exposure. The groups did not differ in transient evoked otoacoustic emission signal-to-noise ratio.

Conclusion
These results diverge from the shallow ARGF pattern observed in studies of noise-induced cochlear synaptopathy and are suggestive of a central mechanism of auditory dysfunction in patients with AG-induced ototoxicity.
The physical properties of local (U)LIRGs: A comparison with nearby early- and late-type galaxies
Authors: Paspaliaris E.-D. , Xilouris E. M. , Nersesian A. , Masoura V. A. , Plionis M. , Georgantopoulos I. , Bianchi S. , Katsioli S. , Mountrichas G. 
Published: March 2021

Aims. In order to pinpoint the place of the (ultra-) luminous infrared galaxies ((U)LIRGs) in the local Universe, we examine the properties of a sample of 67 such nearby systems and compare them with those of 268 early- and 542 late-type, well studied, galaxies from the DustPedia database.
Methods. We made use of multi-wavelength photometric data (from the ultra-violet to the sub-millimetre), culled from the literature, and the CIGALE spectral energy distribution fitting code to extract the physical parameters of each system. The median spectral energy distributions as well as the values of the derived parameters were compared to those of the local early- and late-type galaxies. In addition to that, (U)LIRGs were divided into seven classes, according to the merging stage of each system, and variations in the derived parameters were investigated.
Results. (U)LIRGs occupy the ‘high-end’ on the dust mass, stellar mass, and star-formation rate (SFR) plane in the local Universe with median values of 5.2 × 107 M⊙, 6.3 × 1010 M⊙, and 52 M⊙ yr−1, respectively. The median value of the dust temperature in (U)LIRGs is 32 K, which is higher compared to both the early-type (28 K) and the late-type (22 K) galaxies. The dust emission in PDR regions in (U)LIRGs is 11.7% of the total dust luminosity, which is significantly higher than early-type (1.6%) and late-type (5.2%) galaxies. Small differences in the derived parameters are seen for the seven merging classes of our sample of (U)LIRGs with the most evident one being on the SFR, where in systems in late merging stages (‘M3’ and ‘M4’) the median SFR reaches up to 99 M⊙ yr−1 compared to 26 M⊙ yr−1 for the isolated ones. In contrast to the local early- and late-type galaxies where the old stars are the dominant source of the stellar emission, the young stars in (U)LIRGs contribute with 64% of their luminosity to the total stellar luminosity. The fraction of the stellar luminosity absorbed by the dust is extremely high in (U)LIRGs (78%) compared to 7% and 25% in early- and late-type galaxies, respectively. The fraction of the stellar luminosity used to heat up the dust grains is very high in (U)LIRGs, for both stellar components (92% and 56% for the young and the old stellar populations, respectively) while 74% of the dust emission comes from the young stars.
Stem constancy under the microscope
Authors: Hettwer Caroline , Fuhrhop Nanna 
Published: March 2021

Abstract
Writing systems show variation in stem spellings,
for example with double consonant letters. In German, the double
consonant is always preserved (e.g., rennen –
rennt, “to run – runs”), while in Dutch it is not
(rennen – rent). In English <nn> is
normally not preserved (running – run), though in
French it varies: bonne – bon (“well” feminine –
masculine), donner – donne (“to give – (I) give”).
There are different regularities for double consonant spellings in
all four languages; thus, stem constancy varies in strength
depending on the language. In order to develop a typology of writing
systems, language-specific types and limitations of stem constancy
need to be described in greater detail. This chapter will do this by
examining the above-mentioned four languages. It will compare the
strength and degree of systematicity of stem constancy, as well as
issues of frequency. Mark Aronoff was always interested in spelling
systems and he is a morphologist – so this chapter is dedicated to
Mark.
Major lexical categories and graphemic weight
Authors: Berg Kristian 
Published: March 2021

Abstract
English spelling has a very interesting
regularity: there exists a minimum word length for lexical words.
Words of this class have to be at least three letters long, even if
they consist of only two phonemes and could be spelled with two
letters (e.g., ebb/*eb, egg/*eg).
This regularity does not hold for function words (e.g.,
a, I, be,
he, it, etc.). This means that
an important distinction between words (lexical vs. functional) is
mirrored in the writing system. In a study of Early Modern English
texts, I demonstrate that this regularity evolved gradually over the
course of 200 years. This is a case of self-organization in
spelling: without explicit guidance or regulation, the pattern
emerged in usage. The proposed function of having separate
constraints for the length of lexical words and function words is a reading aid.
Two-suffix combinations in native and non-native English
Authors: Manova Stela , Knell Georgia 
Published: March 2021

Abstract
We demonstrate the existence of a novel type of
morphomic structure: the suffix combination in word formation. We
ran two psycholinguistic experiments with 45 native and 30
non-native English speakers, asking them to judge whether or not
existing and non-existing two-suffix combinations presented without
bases occur in English. Both groups identified existing and
non-existing suffix combinations with very high accuracy; productive
combinations were recognized more accurately than unproductive ones.
Our research shows that suffix combinations are listed in the mental
lexicon as morphomes. This finding accords with recent research in
natural language processing that induces a language’s patterns,
rules, and semantics based entirely on form relations. We also
discuss other possible applications of the morphome outside of
theoretical linguistics.
El género tesis de licenciatura en lingüística
Authors: Lobos Ignacio , Venegas René 
Published: March 2021

Abstracta
El estudio de los géneros discursivos académicos ha recibido una especial atención en la última década. No
obstante, los estudios sobre el género tesis de licenciatura son escasos, especialmente desde la perspectiva léxico-gramatical.
Nuestro objetivo es describir léxico-gramaticalmente cada movimiento del género tesis de licenciatura en lingüística, a partir de
la extracción y cuantificación de trigramas de lemas en 33 tesis de licenciatura en lingüística. Para ello se utiliza la
lingüística de corpus, pues permite etiquetar automáticamente sus unidades léxicas e identificar patrones de lemas usados para el
análisis estadístico. Entre los hallazgos se destaca que los trigramas de lemas diferencian en un 99,3% los movimientos. Además,
se identifican los trigramas propios de cada movimiento, estos se relacionan funcionalmente con los propósitos comunicativos. Los
hallazgos establecen una clara relación entre las formas lingüísticas y las funciones comunicativas en este género. Los resultados
tienen aplicaciones para el desarrollo de herramientas de apoyo a la escritura desde una pedagogía basada en el género.
First-principles characterisation of structural and electronic properties of some RuO2 crystals
Authors: Maurya V , Sharma G , Joshi K B 
Published: March 2021

Abstract
Density functional theory at the level of LDA, GGA, LDA + U, GGA + U and hybrid functionals is applied to investigate structural and electronic properties of three RuO2 crystals. The rutile structure, and the pyrite and flourite modifications of RuO2 are undertaken. The structural properties, enthalpy-pressure curves, electronic states, and Fermi surfaces are presented. The enthalpy-pressure curves show that pressure causes the rutile-RuO2 to transform into pyrite and flourite phases. The pyrtie phase transforms in the fluorite phase. All calculations point out pressure induced rutile → pyrite phase transition in confirmation with the experimental studies. The pyrite → fluorite transition is pointed out by current calculations. The rutile and pyrite crystals are metals while hypothetical fluorite is a semiconductor. All calculations show s that the fluorite has an indirect bandgap in the 0.57–2.96 eV range. The Fermi surface of metallic rutile structure using GGA + U shows improvement over GGA on comparison with the measurement. The GGA + U calculations suggest that rutile → fluorite and pyrite → fluorite metal-insulator transitions are accompanied by orbital ordering.
Pushing run-and-tumble particles through a rugged channel
Authors: Bijnens Bram , Maes Christian 
Published: March 2021

Abstract
We analyze the case of run-and-tumble particles pushed through a rugged channel both in the continuum and on the lattice. The current characteristic is non-monotone in the external field with the appearance of a current and nontrivial density profile even at zero field for asymmetric obstacles. If an external field is exerted against the direction of that zero-field current, then the resulting current decreases with persistence at small field and increases with persistence at large field. Activity in terms of self-propulsion increases the maximal current and postpones dying. We give an effective theoretical description with wider validity.
Planning of Service Mobile Robot Based on Convolutional LSTM Network
Authors: Yin Shuai , Yuschenko Arkady 
Published: March 2021

Abstract
This paper proposes method that can complete motion planning in one step using convolutional Long Short-Term Memory (LSTM) network. Service mobile robot movement from the starting position to the target position includes three main tasks: mapping, positioning, motion planning. The convolutional LSTM network mainly is used to complete motion planning. The input of the network is a GRB picture with obstacles, target position, starting position. The outputs of the network are linear velocity and angular velocity of service mobile robot. The convolution layer of the network is to mark obstacles, target position and starting position. LSTM layer describes the time characteristics of movement and full connected layer is used to smoothly fit linear velocity and angular velocity of service mobile robot. The convolutional LSTM network can complete tasks of path finding and control, that is, mapping pictures with obstacles, target position, starting position to linear velocity and angular velocity of service mobile robot. Compared with traditional separate solutions for motion tasks, this method has obvious advantages such as good fault tolerance and complete motion tasks planning in real time. In experiment, a mobile robot “Turtlebot” based on ROS systems was used to verify the effectiveness and convenience of the method for motion planning.