bluuebunny/crossref_metadata_2025_split huggingface dataset:
Positive Pressure Testing Booths Development and Deployment in Response to the COVID-19 Outbreak
Authors: Aroom Kevin , Ge Jiawei , Al-Zogbi Lidia , White Marcee , Trustman Adrienne , Greenbaum Adena , Farley Jason , Krieger Axel 
Published: September 2021

Abstract
The COVID-19 pandemic left an unprecedented impact on the general public health, resulting in hundreds of thousands of deaths in the U.S. alone. Nationwide testing plans were initiated with drive-through being the currently dominant testing approach, which, however, exhausts personal protective equipment supplies, and is unfriendly to individuals not owning a vehicle. Walkup positive pressure testing booths are a safe alternative, whereby a health care provider situated on the inside of an enclosed and positively pressurized booth swabs a patient on the outside through chemical resistant gloves. The booths, however, are too prohibitively priced on the market to allow for nationwide deployment. To mitigate this, we present in this paper a safe, accessible, mobile, and affordable design of positive-pressure COVID-19 testing booths. The booths have successfully passed the Centers for Disease Control and Prevention and Health care Infection Control Practices Advisory Committee pressure, air exchange, and air quality requirements for positive-pressure rooms, following the guidelines for environmental infection control in health care facilities. The booths are manufactured using primarily off-the-shelf components from U.S. vendors with minimized customization, and the final bill of materials does not surpass USD 3,900. Since August 2019, five booths were deployed and used at the Johns Hopkins University School of Nursing, Baltimore City Health Department, and two community health centers in Baltimore. No health care provider was infected when using our booths, which have shown to facilitate walkup testing with decreased personal protective equipment consumption, reduced risk of infection, and enhanced accessibility to lower-income communities and nondrivers.
Investigation of Critical Heat Flux for Plutonium-Based Mixed Oxide Advanced Fuel Bundle Design
Authors: Yuan Lan Qin , Yang Jun , Addicott Bruce , Dickerson Matthew , Gauthier Vinson 
Published: September 2021

Abstract
The critical heat flux (CHF) performance of an advanced plutonium-based mixed oxide (MOX) fuel for potential use in a pressure tube heavy water reactor (PT-HWR) has been studied experimentally at Canadian Nuclear Laboratories with an electrically heated string simulator of 43-element fuel bundles. The fuel simulator has a uniform axial power profile and a radial power profile that is representative of the plutonium-based MOX fuel. The measurements of CHF caused by liquid-film dryout were made in the MR-3 heat transfer loop facility using R-134a refrigerant as the working fluid. The test matrix included system pressures from 1.47 to 2.11 MPa, mass flow rates from 12.7 to 14.7 kg/s and inlet temperatures from 31 to 59 °C, which are representative of the water-equivalent reactor operating conditions of 9 to 12.5 MPa pressure, 13.5 to 21.3 kg/s mass flow rate and the desired inlet subcoolings. Compared to conventional natural uranium fuel, the radial power profile of a MOX fuel exhibits a steeper and less even distribution across the fuel element rings, with a relatively higher power in the outer ring. It was found that CHF values of the MOX fuel are significantly lower than those of the natural uranium fuel. Based on the experimental data, a correlation has been derived to account for the effect of radial power profile on CHF. This correlation can be used to evaluate the relative CHF values of advanced or nonconventional fuel designs with radial power profiles deviating from that of natural uranium fuel.
Sliding Mode Control for Two-Degree-of-Freedom Fractional Zener Oscillator
Authors: Yuan Jian , Gao Song , Wang Liying , Xiu Guozhong 
Published: September 2021

Abstract
Fractional-order derivatives provide a powerful tool for the characterization of mechanical properties of viscoelastic materials. Fractional oscillators are mechanical models of viscoelastically damped structures, the viscoelastic damping of which is described by fractional-order constitutive equations. This paper proposes sliding mode control for a two-degree-of-freedom fractional Zener oscillator. Firstly, a virtual fractional oscillator is generated by means of a state transformation. Then, the total mechanical energy in the virtual oscillator is determined as the sum of the kinetic energy, the potential energy, and the fractional energy. Furthermore, sliding mode control for the fractional Zener oscillator is designed, in which the Lyapunov function is defined by the total mechanical energy. Finally, numerical simulations are conducted to validate the effectiveness of the proposed controllers.
Investigation on Swirl Instability in a Vane-Type Separator With Tomographic Particle Image Velocimetry
Authors: Zhang Tingting , Huang Guangyuan , Yin Junlian , Zhang Zekai , Wang Dezhong , Sun Yan , Liao Yixiang 
Published: September 2021

Abstract
The separation efficiency of a vane-type separator is greatly affected by swirl instability. The separator consists of a swirling vane, a recovery vane and a main pipe. Driven by centrifugal force, the bubbly flow tends to develop into stratified flow with a continuous gas core floating in the central axis of the separator and facilitating the separation. Yet, the straight gas core can turn into a double helix under some circumstances, for example, if the pressure difference across the orifices of recovery vane falls below the critical value, and swirl instability occurs. In order to reveal the underlying mechanism, a device with adjustable operating pressure was introduced to reproduce the dynamic process of gas core transform between stable and unstable. With the increase of pressure difference, the gas core morphology near the recovery vane will turn from double-helix to straight-line within several seconds. The whole process was investigated further by using the tomographic particle image velocimetry (PIV). Results show that the development of vorticity structures in the swirl flow gives rise to the evolution of gas core morphology and keeps it stable. Furthermore, the direction of axial velocity, which becomes negative by low pressure differences, is found to be crucial in controlling the formation of inner forced vortex and hence leading to the occurrence of swirl instability. In addition, the magnitude of positive axial velocity is identified to be of great significance in vorticity enhancement.
Electromyography-Assisted Neuromusculoskeletal Models Can Estimate Physiological Muscle Activations and Joint Moments Across the Neck Before Impacts
Authors: Silvestros Pavlos , Pizzolato Claudio , Lloyd David G. , Preatoni Ezio , Gill Harinderjit S. , Cazzola Dario 
Published: September 2021

Abstract
Knowledge of neck muscle activation strategies before sporting impacts is crucial for investigating mechanisms of severe spinal injuries. However, measurement of muscle activations during impacts is experimentally challenging and computational estimations are not often guided by experimental measurements. We investigated neck muscle activations before impacts with the use of electromyography (EMG)-assisted neuromusculoskeletal models. Kinematics and EMG recordings from four major neck muscles of a rugby player were experimentally measured during rugby activities. A subject-specific musculoskeletal model was created with muscle parameters informed from MRI measurements. The model was used in the calibrated EMG-informed neuromusculoskeletal modeling toolbox and three neural solutions were compared: (i) static optimization (SO), (ii) EMG-assisted (EMGa), and (iii) MRI-informed EMG-assisted (EMGaMRI). EMGaMRI and EMGa significantly (p &lt; 0.01) outperformed SO when tracking cervical spine net joint moments from inverse dynamics in flexion/extension (RMSE = 0.95, 1.14, and 2.32 N·m) but not in lateral bending (RMSE = 1.07, 2.07, and 0.84 N·m). EMG-assisted solutions generated physiological muscle activation patterns and maintained experimental cocontractions significantly (p &lt; 0.01) outperforming SO, which was characterized by saturation and nonphysiological “on-off” patterns. This study showed for the first time that physiological neck muscle activations and cervical spine net joint moments can be estimated without assumed a priori objective criteria before impacts. Future studies could use this technique to provide detailed initial loading conditions for theoretical simulations of neck injury during impacts.
Wetted Ice With Elastic Wrap Decreases Intramuscular Temperature More Quickly Than Game Ready®
Authors: Anderson Courtney R. , Gange Kara N. , Christensen Bryan , Vettern Rachelle 
Published: September 2021

Cryotherapy is a popular treatment chosen by health care providers to treat musculoskeletal injuries. The purpose of this study was to determine which cryotherapy method, Game Ready® or a wetted ice bag with elastic wrap, caused a greater and faster decline in tissue temperature during a 30-min treatment. At 2 cm below adipose, intramuscular tissue temperatures decreased more and faster with the wetted ice treatment compared with the Game Ready® treatment at all three time points: 10 min, 20 min, and 30 min. Furthermore, wetted ice significantly decreased temperature more than Game Ready® at 20 min (peak change [Ca]GR = 3.40 °C, [Ca]WI = 6.14 °C, p = .03) and 30 min ([Ca]GR = 5.62 °C, [Ca]WI = 8.67 °C, p = .02). One of the primary goals after injury is to lower tissue temperature to decrease cellular metabolism to reduce the risk of secondary ischemic injury. No evidence exists to support the optimal tissue temperature decrease for specific physiological results with cryotherapy. However, the literature is consistent with modalities producing colder temperatures are considered a better immediate care modality to decrease cell metabolism as much as possible. Therefore, these findings suggest wetted ice with an ACE wrap would be the more effective treatment in the immediate care phase.
Validating an Adjustment to the Intermittent Critical Power Model for Elite Cyclists—Modeling W′ Balance During World Cup Team Pursuit Performances
Authors: Bartram Jason C. , Thewlis Dominic , Martin David T. , Norton Kevin I. 
Published: September 2021

Purpose: Modeling intermittent work capacity is an exciting development to the critical power model with many possible applications across elite sport. With the Skiba 2 model validated using subelite participants, an adjustment to the model’s recovery rate has been proposed for use in elite cyclists (Bartram adjustment). The team pursuit provides an intermittent supramaximal event with which to validate the modeling of W′ in this population. Methods: Team pursuit data of 6 elite cyclists competing for Australia at a Track World Cup were solved for end W′ values using both the Skiba 2 model and the Bartram adjustment. Each model’s success was evaluated by its ability to approximate end W′ values of 0 kJ, as well as a count of races modeled to within a predetermined error threshold of ±1.840 kJ. Results: On average, using the Skiba 2 model found end W′ values different from zero (P = .007; mean ± 95% confidence limit, –2.7 ± 2.0 kJ), with 3 out of 8 cases ending within the predetermined error threshold. Using the Bartram adjustment on average resulted in end W′ values that were not different from zero (P = .626; mean ± 95% confidence limit, 0.5 ± 2.5 kJ), with 4 out of 8 cases falling within the predetermined error threshold. Conclusions: On average, the Bartram adjustment was an improvement to modeling intermittent work capacity in elite cyclists, with the Skiba 2 model underestimating the rate of W′ recovery. In the specific context of modeling team pursuit races, all models were too variable for effective use; hence, individual recovery rates should be explored beyond population-specific rates.
Power Profile of Top 5 Results in World Tour Cycling Races
Authors: van Erp Teun , Lamberts Robert P. , Sanders Dajo 
Published: September 2021

Purpose: This study evaluated the power profile of a top 5 result achieved in World Tour cycling races of varying types, namely: flat sprint finish, semi-mountain race with a sprint finish, semi-mountain race with uphill finish, and mountain races (MT). Methods: Power output data from 33 professional cyclists were collected between 2012 and 2019. This large data set was filtered so that it only included top 5 finishes in World Tour races (18 participants and 177 races). Each of these top 5 finishes were subsequently classified as flat sprint finish, semi-mountain race with uphill finish, semi-mountain race with a sprint finish, and MT based on set criteria. Maximal mean power output (MMP) for a wide range of durations (5 s to 60 min), expressed in both absolute (in Watts) and relative terms (in Watts per kilogram), were assessed for each race type. Result: Short-duration power outputs (<60 s), both in relative and in absolute terms, are of higher importance to be successful in flat sprint finish and semi-mountain race with a sprint finish. Longer-duration power outputs (≥3 min) are of higher importance to be successful in semi-mountain race with uphill finish and MT. In addition, relative power outputs of >10 minutes seem to be a key determining factor for success in MT. These race-type specific MMPs of importance (ie, short-duration MMPs for sprint finishes, longer-duration MMPs for races with more elevation gain) are performed at a wide range (80%–97%) of the cyclist’s personal best MMP. Conclusions: This study shows that the relative importance of certain points on the power–duration spectrum varies with different race types and provides insight into benchmarks for achieving a result in a World Tour cycling race.
Dacryolithiasis diagnosis and treatment: a 25-year experience using nasal endoscopy
Authors: Khorrami Kashi Alexis , Keilani Chafik , Nguyen Thien-Huong , Keller Pierre , Elahi Sina , Piaton Jean-Marie 
Published: September 2021

BackgroundDacryolith-induced epiphora is caused by a chronic obstruction of the nasolacrimal duct whose aetiology is often specified peroperatively. Dacryocystorhinostomy (DCR) has been often regarded as the gold standard to treat dacryolithiasis. Hasner’s valve (HV) incision is a technique to evacuate lithiasis through its physiological track. The purpose of this study was to describe clinical and radiological findings associated with presence of dacryoliths in patients who underwent surgery and to assess the efficacy of these two procedures.MethodsThis study was a comparative interventional multicentric retrospective study including patients referred for an epiphora. The primary endpoint was to determine clinical and endoscopic findings associated with dacryoliths. The secondary endpoints were to evaluate the performance of CT dacryocystography (CT-DG) in the diagnosis of dacryoliths and the success rate of the surgical treatment 6 months postoperatively.Results4677 nasolacrimal ducts (NLDs) (78.0% female, mean age 59.2) were included in the study. 3913 underwent DCR, and 764 underwent HV incision. 291 out of 4677 NLDs (6.2%) were found to have dacryoliths. Presence of mucocele associated to a permeable lacrimal system (OR 8.17 (95% 4.62 to 14.44), p<0.01) was associated with presence of lithiasis peroperatively. Success rates at 6 months were 95.6% for endonasal DCR and 94.6% for incision of HV in dacryolithiasis group (p<0.01). CT-DG had a negative predictive value of 96.3% to detect lithiasis (p<0.01).ConclusionStrong clinical and endoscopic findings may improve the imputability of dacryoliths in epiphora. Evacuation of dacryolithiasis through its physiological track was first described in this study in adults with similar results to DCR in patients presenting with dacryolithiasis.
Serological responses to SARS-CoV-2 following non-hospitalised infection: clinical and ethnodemographic features associated with the magnitude of the antibody response
Authors: Shields Adrian M , Faustini Sian E , Perez-Toledo Marisol , Jossi Sian , Allen Joel D , Al-Taei Saly , Backhouse Claire , Dunbar Lynsey A , Ebanks Daniel , Emmanuel Beena , Faniyi Aduragbemi A , Garvey Mark , Grinbergs Annabel , McGinnell Golaleh , O'Neill Joanne , Watanabe Yasunori , Crispin Max , Wraith David C , Cunningham Adam F , Drayson Mark T , Richter Alex G 
Published: September 2021

ObjectiveTo determine clinical and ethnodemographic correlates of serological responses against the SARS-CoV-2 spike glycoprotein following mild-to-moderate COVID-19.DesignA retrospective cohort study of healthcare workers who had self-isolated due to COVID-19.SettingUniversity Hospitals Birmingham NHS Foundation Trust, UK (UHBFT).Participants956 healthcare workers were recruited by open invitation via UHBFT trust email and social media between 27 April 2020 and the 8 June 2020.InterventionParticipants volunteered a venous blood sample that was tested for the presence of anti-SARS-CoV-2 spike glycoprotein antibodies. Results were interpreted in the context of the symptoms of their original illness and ethnodemographic variables.ResultsUsing an assay that simultaneously measures the combined IgG, IgA and IgM response against the spike glycoprotein (IgGAM), the overall seroprevalence within this cohort was 46.2% (n=442/956). The seroprevalence of immunoglobulin isotypes was 36.3%, 18.7% and 8.1% for IgG, IgA and IgM, respectively. IgGAM identified serological responses in 40.6% (n=52/128) of symptomatic individuals who reported a negative SARS-CoV-2 PCR test. Increasing age, non-white ethnicity and obesity were independently associated with greater IgG antibody response against the spike glycoprotein. Self-reported fever and fatigue were associated with greater IgG and IgA responses against the spike glycoprotein. The combination of fever and/or cough and/or anosmia had a positive predictive value of 92.3% for seropositivity in self-isolating individuals a time when Wuhan strain SARS-CoV-2 was predominant.Conclusions and relevanceAssays employing combined antibody detection demonstrate enhanced seroepidemiological sensitivity and can detect prior viral exposure even when PCR swabs have been negative. We demonstrate an association between known ethnodemographic risk factors associated with mortality from COVID-19 and the magnitude of serological responses in mild-to-moderate disease.
Heavy alcohol consumption before and after negative life events in late mid-life: longitudinal latent trajectory analyses
Authors: Agahi Neda , Morin Lucas , Virtanen Marianna , Pentti Jaana , Fritzell Johan , Vahtera Jussi , Stenholm Sari 
Published: September 2021

BackgroundPeople who experience negative life events report more heavy alcohol consumption compared with people without these experiences, but little is known about patterns of change within this group. This study aims to identify trajectories of heavy alcohol consumption before and after experiencing either divorce, or severe illness or death in the family. Furthermore, the aim is to examine characteristics of individuals belonging to each trajectory.MethodsLongitudinal study of public sector employees from the Finnish Retirement and Aging Study with up to 5 years of annual follow-ups (n=6783; eligible sample n=1393). Divorce and severe illness or death in the family represented negative life events. Heavy alcohol consumption was categorised as >14 units/week.ResultsBased on latent trajectory analysis, three trajectories of heavy drinking were identified both for divorce and for severe illness or death in the family: ‘No heavy drinking’ (82% illness/death, 75% divorce), ‘Constant heavy drinking’ (10% illness/death, 13% divorce) and ‘Decreasing heavy drinking’ (7% illness/death, 12% divorce). Constant heavy drinkers surrounding illness or death in the family were more likely to be men, report depression and anxiety and to smoke than those with no heavy drinking. Constant heavy drinkers surrounding divorce were also more likely to be men and to report depression compared with those with no heavy drinking.ConclusionsMost older workers who experience divorce or severe illness or death in the family have stable drinking patterns regarding heavy alcohol consumption, that is, most do not initiate or stop heavy drinking.
Self-management intervention to reduce pulmonary exacerbations by supporting treatment adherence in adults with cystic fibrosis: a randomised controlled trial
Authors: Wildman Martin J , O’Cathain Alicia , Maguire Chin , Arden Madelynne A , Hutchings Marlene , Bradley Judy , Walters Stephen J , Whelan Pauline , Ainsworth John , Buchan Iain , Mandefield Laura , Sutton Laura , Tappenden Paul , Elliott Rachel A , Hoo Zhe Hui , Drabble Sarah J , Beever Daniel 
Published: September 2021

IntroductionRecurrent pulmonary exacerbations lead to progressive lung damage in cystic fibrosis (CF). Inhaled medications (mucoactive agents and antibiotics) help prevent exacerbations, but objectively measured adherence is low. We investigated whether a multi-component (complex) self-management intervention to support adherence would reduce exacerbation rates over 12 months.MethodsBetween October 2017 and May 2018, adults with CF (aged ≥16 years; 19 UK centres) were randomised to the intervention (data-logging nebulisers, a digital platform and behavioural change sessions with trained clinical interventionists) or usual care (data-logging nebulisers). Outcomes included pulmonary exacerbations (primary outcome), objectively measured adherence, body mass index (BMI), lung function (FEV1) and Cystic Fibrosis Questionnaire-Revised (CFQ-R). Analyses were by intent to treat over 12 months.ResultsAmong intervention (n=304) and usual care (n=303) participants (51% female, median age 31 years), 88% completed 12-month follow-up. Mean exacerbation rate was 1.63/year with intervention and 1.77/year with usual care (adjusted ratio 0.96; 95% CI 0.83 to 1.12; p=0.64). Adjusted mean differences (95% CI) were in favour of the intervention versus usual care for objectively measured adherence (9.5% (8.6% to 10.4%)) and BMI (0.3 (0.1 to 0.6) kg/m2), with no difference for %FEV1(1.4 (−0.2 to 3.0)). Seven CFQ-R subscales showed no between-group difference, but treatment burden reduced for the intervention (3.9 (1.2 to 6.7) points). No intervention-related serious adverse events occurred.ConclusionsWhile pulmonary exacerbations and FEV1did not show statistically significant differences, the intervention achieved higher objectively measured adherence versus usual care. The adherence difference might be inadequate to influence exacerbations, though higher BMI and lower perceived CF treatment burden were observed.
Neutrino energy-loss rate in 331β model
Authors: Binh D. T. , Hue L. T. , Binh V. H. , Long H. N. 
Published: September 2021

We evaluate the stellar energy-loss rates [Formula: see text] due to the production of neutrino pair in 3-3-1 models. The energy loss rate [Formula: see text] is evaluated for different values of [Formula: see text] in which [Formula: see text] is a parameter used to define the charge operator in the 331 models. We show that the contribution of dipole moment to the energy loss rate is small compared to the contribution of new natural gauge boson [Formula: see text]. The correction [Formula: see text] compared with that of Standard Model is evaluated and do not exceed 14% and is highest with [Formula: see text]. Of all the evaluated models, model with [Formula: see text] give a relative large [Formula: see text] correction for the mass of [Formula: see text][Formula: see text] GeV. This mass range is within the searching range for [Formula: see text] boson at LHC.