bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dose-Dependent Efficacy of Aripiprazole in Treating Patients With Schizophrenia or Schizoaffective Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Qian Li , Xuemei Liao , Jitao Li , Yun'Ai Su , Tianmei Si 
Published: August 2021

Purpose: To compare the efficacy and tolerability of different administration strategies of aripiprazole.Methods: We searched MEDLINE, EMBASE, the Cochrane Central, Web of Science, China National Knowledge Infrastructure(CNKI), and Wanfang Data Knowledge Service Platform(Wanfang) for randomized controlled trials (RCTs) of aripiprazole, using the terms: (aripiprazole) AND (schizophr* OR schizoaff*) AND (“syndrome scale” OR PANSS) AND (clini* OR trial). We retrieved study design, participant characteristics, comparison groups, and outcomes from each study.Results: In total, nine RCTs were selected for meta-analysis, which covered ~1,187 participants. We defined two treatment groups that represent different treatment strategies: (1) the high-dose group (the high-dose strategy) rapidly increased to doses higher than 15 mg/day in 2 weeks or began with doses higher than 15 mg/day, otherwise the group was defined as (2) the low-dose group (the low-dose strategy). If the initial or target doses of aripiprazole in a study were all higher than 15 mg/day, the high- and low-dose groups were created based on the relative level of the dose. The high-dose group showed significantly greater reductions in Positive and Negative Syndrome Scale (PANSS) total scores (standardized mean differences = −8.31, 95% confidence interval [CI] = −16.48, −0.13; P &lt; 0.01; I2 = 96%) than the low-dose group. The high-dose group showed superior effects compared with the low-dose group in long-term studies (more than 8 weeks) (standardized mean differences = −13.81, 95% CI = −25.07, −2.55; P &lt; 0.01; I2 = 96%). With exception of somnolence, we did not find significant differences in side effects or discontinuation due to adverse events. Sensitivity analyses produced similar results.Conclusion: The high-dose treatment strategy of aripiprazole for patients with schizophrenia or schizoaffective disorder may bring more benefits without obvious side effects.
Literature Review: Pengaruh Edukasi Tentang Anemia Melalui Media Cetak Dan Media Audio Visual Kepada Remaja Putri
Authors: Ester Stephanie Victoria , Ratih Kurniasari  
Published: August 2021

Anemia is a disease caused by the body's lack of iron nutrients, particularly in the formation of hemoglobin. The National Institute of Health, a 2011 case in which teenage girls are suffering from anemia (10 to 19 years old). In the case of anemia where HB does not reach the baseline, it can cause stress and persistent fatigue in the body's organs and can be inhibited activities and decreased of academic achievement. The purpose of this study is to find out the impact of nutrition education for students by providing printed media and audio-visual media relating with anemia, such as impact to knowledge, attitudes and behaviors. The method used by author in this study is some literatures related subject of this study. The result of the study will help the readers and health workers to know and able to make nutrition education plan about anemia for teenage girls by using printed media and audio-visual media.
ABSTRAK
Anemia adalah penyakit yang disebabkan oleh kekurangan asupan zat gizi besi didalam tubuh, di mana hal ini sangat berperan dalam membentuk hemoglobin. Remaja putri (10-19 tahun) merupakan salah satu kelompok yang sangat rawan mengalami anemia (National Institute of Health, 2011). Dalam kasus anemia, apabila kandungan Hb tidak mencapai batas normal dapat menyebabkan komplikasi seperti stres dan kelelahan yang berkelanjutan sehingga dapat menimbulkan rasa lelah, letih dan lesu pada organ tubuh dan mengganggu aktifitas serta mengakibatkan penurunan prestasi belajar. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian pendidikan gizi dengan menggunakan media cetak dan media audio-visual pada siswa terkait pengetahuan, sikap dan perilaku mengenai anemia. Metode yang digunakan penulis dalam kajian ini yaitu dengan menggunakan beberapa literatur yang berkaitan dengan judul kajian ini. Hasil dan pembahasan kajian ini akan membantu pembaca serta tenaga kesehatan dalam membuat perencanaan edukasi gizi kepada remaja putri mengenai anemia menggunakan media cetak dan media audio-visual.
Ecos das Revoluções de 1848 no Brasil: formas de pensamento, literatura política e transferências culturais
Authors: Deaecto Marisa Midori 
Published: August 2021

O presente artigo propõe um estudo sobre a recepção dos debates políticos ensejados durante as Revoluções de 1848, na Europa, a partir de suas matrizes francesas, entre literatos e figuras políticas atuantes no Brasil. A análise parte da leitura que os jornais cariocas fizeram da Revolução que eclode em Paris, em 23 de fevereiro de 1848, destronando o rei Luís Filipe. Para melhor dimensionar o comportamento da imprensa e de seus arautos nesse momento, propõe-se um quadro comparativo entre o parti pris político dos formadores da opinião pública frente à Revolução de 1830 e, depois, em 1848. Tal perspectiva nos permite observar, por meio de um estudo de caso, a saber, a recepção do libelo antidemocrático de François Guizot, o modus operandi da classe política na promoção da propaganda antirrevolucionária (em 1848), ao mesmo tempo que a imagem do jurista e ideólogo francês será reabilitada em uma chave oposta àquela apreendida em 1830. Ou seja, de paladino das liberdades constitucionais, o doutrinário francês se converte em opositor visceral do sufrágio universal e das lutas sociais, num só termo, do que ele classifica como “idolatria democrática”.
Le genre national comme transfert culturel
Authors: Schläpfer Anne-Frédérique 
Published: August 2021

Cet article propose de considérer les relations entre la littérature francophone et les littératures étrangères en s’appuyant sur la notion de genre national. Bien que la théorie et l’histoire littéraires aient recouvert le concept de genre national par d’autres types de catégorisation, l’article cherche à montrer qu’il n’en a pas moins structuré les manières de penser la circulation mondiale de la littérature tout au long de la première partie de XXe siècle et qu’il constitue, dès lors, un exemple particulier de transfert culturel. En partant de l’exemple du « roman anglais », façonné dans le monde francophone entre le début des années 1920 et la fin des années 1940 à partir d’une vague de traductions, il s’agit de restituer comment la réception francophone a construit ce genre national, quels acteurs y ont participé et quels usages ils ont en proposé.
Les prémisses du transfert culturel dans les sciences humaines russes du XXe siècle: la contribution de Vladimir Stasov
Authors: Dmitrieva Ekaterina 
Published: August 2021

En Russie, la « poétique historique », qui est étroitement liée au nom d'Alexandre Veselovski (1838-1906), a profondément façonné l'histoire de la littérature comparée. La puissante figure de Veselovski a en même temps remis dans l’ombre les activités de ses prédécesseurs et de savants partageant les mêmes idées, dont le critique d`art Vladimir Stasov. Celui-ci, jouissant d'une autorité incontestable dans des domaines très éloignés de la théorie de l'emprunt, fut également auteur d`un certain nombre d` études, semi-oubliées aujourd'hui, dans lesquelles, tout en défendant l`idée de l'art national, il tente en même temps de prouver la continuité de l'art russe par rapport à l'art asiatique. La question est de savoir comment l'exigence d'identité (samobytnost1) dont Stasov se montre un grand adepte, pouvait être liée dans son esprit à la conviction de la composante orientale de cette identité. Comment l'idée cosmopolite et l'idée nationale peuvent-elles être corrélées ? et quelles sont les composantes étrangères qui sous-tendent l'identité nationale ? Cette dernière question nous amène à nous demander sur les prémisses lointaines de la théorie des transferts culturels qui sont à chercher, par ailleurs, en Russie du 19e siècle.
Tipos moleculares de cáncer de mama en el Hospital Roosevelt, Guatemala
Authors: Ramírez Mirza , De-León Juan 
Published: August 2021

Introducción: el cáncer de mama es una de las mayores causas de morbilidad y mortalidad en el mundo. Con frecuencia muestra un comportamiento biológico diferente al esperado, por lo que lograr un diagnóstico correcto permitiría escoger una terapia personalizada. Por medio de la clasificación molecular, este objetivo se está haciendo posible. Objetivo: determinar el tipo molecular del cáncer de mama en pacientes del Hospital Roosevelt, del 2015 al 2019. Material y métodos: estudio retrospectivo en 180 pacientes que cumplieron con los criterios de inclusión. Resultados: el grupo etario más frecuente fue el comprendido entre 51 y 60 años. El tipo histológico más común fue el carcinoma ductal invasor. El 63.3% correspondió a un grado histológico II. En la clasificación molecular, hubo un predominio del subtipo Luminal A; seguido del triple negativo. Se encontró una pequeña población de triples positivos (7.2%). Conclusión: El subtipo Luminal A fue el más frecuente, seguido de los casos triple negativos.
Implementasi Sistem Informasi Sekolah pada Pusat Kegiatan Belajar Mengajar (PKBM) Patrakomala Berbasis Web
Authors: Widayani Hapsari , Robbani Hamzah , Rosadi Nicky 
Published: August 2021

Abstrak
Kegiatan pengabdian masyarakat ini bertujuan untuk membantu proses belajar mengajar pelayanan administrasi dan pelaporan keuangan pada pusat kegiatan belajar masyarakat dengan sistem yang terintegrasi dengan baik. Kegiatan pengabdian masyarakat ini akan diadakan pada PKBM Patrakomala Peserta ini adalah pegawai/staf keuangan dan guru-guru PKBM. Metode yang digunakan adalah applied research dan dalam kegiatan ini diawali dengan melakukan proses wawancara, observasi, dan pengamatan mengenai administrasi sekolah dan keuangan mitra, lalu mengumpulkan hasil wawancara dan mengenalkan hasil sistem informasi (transfer knowledge) tersebut ke mitra. Adapun produk yang dihasilkan berupa implementasi sistem informasi administrasi sekolah beserta keuangan berbasis web, user interface yang didesain menarik, dan terstruktur dengan baik. Diharapkan implementasi sistem ini dapat dipergunakan dengan baik dan dapat dikembangkan lebih lanjut.
Association of anti dsDNA antibodies titer with non-renal manifestations of Systemic Lupus Erythematosus and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)
Authors: Andleeb Sadaf , Mahmud Tafazzul-E-Haque , Rasheed Aflak , Mehmood Muhammad Shahid , Gull Iram , Ahmed Maria , Mahmud Mufazzal-E-Haque 
Published: August 2021

Background: Early diagnosis and effective treatment in systemic lupus erythematosus (SLE) has very crucial role. Anti dsDNA is very important diagnostic tool and activity marker in SLE. This study aimed to determine the association of anti dsDNA antibodies titer with non-renal manifestations of systemic lupus erythematosus and systemic lupus erythematosus disease activity index (SLEDAI).
Patients and methods: It was a cross-sectional study and was carried out at Department of Rheumatology and Immunology, Tertiary Care Hospital, Lahore from Feb 2021 to May 2021. The study involved 69 male and female patients satisfying the systemic lupus international collaborating clinics (SLICC) classification criteria. Questions regarding different symptoms were asked and disease activity parameters were noted excluding renal parameters. Anti-dsDNA titers were measured from standard laboratory using immunofluorescence technique and were correlated with SLEDAI score. A written informed consent was obtained from every patient.
Results: The mean age of the patients was 30.7±10.2 years while the mean duration of disease 1.94±2.65 years. We observed a female predominance among these patients with male to female ratio of 1:7.6. There were fifty-four (78.3%) patients with active disease. The mean anti-dsDNA levels were significantly higher in patients with active disease (315.73±481.68 vs. 78.46±113.64 IU/mL; p-value=0.003). There was a significantly strong positive correlation between anti-dsDNA levels and SLEDAI score (r=0.358; p-value=0.006). When compared, significant difference was observed in mean anti-dsDNA titers in patients with chronic cutaneous manifestations (p-value=0.040), lymphopenia (p-value= 0.012), pleurisy/pericarditis (p-value= 0.024) and leukopenia <3000/mm3 (p-value= 0.001).
Conclusion: Anti-dsDNA antibodies titers are remarkably increased in patients with non-renal manifestations of systemic lupus erythematosus particularly with chronic cutaneous manifestations and leukopenia and positively correlate with disease activity status and SLEDAI score.
Hepatotoxic effects of Diclofenac and Febuxostat combination on mice liver function tests after oral administration
Authors: Naureen Saima , Waseem Rizwan , Fatima Javaria , Shah Azher Abbas , Manzor Huma , Shaheen Bushra 
Published: August 2021

Background: The liver is a major organ and involved in metabolizing various toxins, including chemicals, drugs, and natural substances.1 Diclofenac is a commonly used non-steroidal anti-inflammatory drug. Febuxostat is a novel non-purine xanthine oxidase inhibitor prescribed in various hyperuricemic states. Rise in liver enzymes with diclofenac use is a well-established fact. When both drugs are used in combination, these may lead to profound hepatotoxicity. To find out these facts this study was planned.
Subjects and methods: An experimental study on mice was planned to explore these facts in University of Health sciences, Lahore. Animals were divided into 6 groups having 10 animals in each group. The animals were given drugs for 7 days. One served as control. 2nd group was given Diclofenac alone (100mg/kg), 3rd group was given Febuxostat (50mg/kg) alone while rest of three groups were administered drugs combination (Diclofenac + Febuxostat). Dose of Diclofenac (100mg/kg) kept constant while dose of Febuxostat increased in each group (5mg/kg, 10mg/kg and 50mg/kg). All drugs administered orally by gavage. After 7 days, the serum levels of liver enzymes assessed. Statistical analysis was performed using SPSS 20. One way ANOVA and Post hoc Tukey tests were applied. A p-value of ≤0.05 was considered statistically significant.
Results: The results showed that Diclofenac and Febuxostat caused liver damage when used separately but hepatotoxicity was much significant (p-value <0.001) when drugs were used in combination.
Conclusion: Both drugs Diclofenac and Febuxostat when administered in combination, causes more liver profound liver damage. That is why their use in combination should be avoided in clinical settings.
Should Patient with Autoimmune Inflammatory Rheumatic Diseases (AIIRD) be vaccinated with COVID-19 Vaccines?
Authors: Wahono Cesarius Singgih , Perdana Aditya  , Faisal Parlindungan  , RM. Suryo Anggoro KW  , Anna Ariane  , Herlina Yani  , Andi Raga Ginting  , Lisa Kurnia Sari  , Pande Ketut Kurniari  , Ratih Manuaba  , Ika Vemilia  , Rudy Hidayat  , Sumariyono Sarmidi  , Harry Isbagjo  
Published: August 2021

Vaccination is a very important measure for the prevention of various infections worldwide including the recent COVID-19 disease. However, until now the COVID-19 vaccine with various platforms has not been clinically tested on autoimmune inflammatory rheumatic disease (AIIRD) patients, due to caution against possible side effects and unknown efficacy. Several recent studies proved that there is increased risk of SARS-CoV-2 infection in AIIRD patients and moreover, those patients also have worse COVID-19 outcomes. Thus, patients with AIIRD should be prioritized for vaccination because they have an increased burden of infections, including COVID-19. Many studies showed that inactivated/non-live vaccine is safe for AIIRD patients and do not cause disease exacerbations. We conclude that benefits of vaccination greatly outweigh the risks of infection and therefore, COVID-19 vaccines can also be administered safely in stable AIIRD patients.
Analisis Mangrove dari Citra Satelit Sebagai Pertahanan Pantai dengan Menggunakan Pendekatan Cloud Computing
Authors: Prasetyo Irawan , Pranowo Widodo S. , Tobing Christian L. , Kurniawan Agung , Puliwarna Tunggul 
Published: August 2021

Pulau Batam merupakan salah satu Pulau di Indonesia yang berbatasan langsung dengan negara Tetangga, sehingga perlu adanya antisipatif pertahanan untuk menghambat infiltrasi atau penyerangan dari ancaman yang bersifat agresif. obstacle buatan dapat menjadi pilihan untuk menghambat infiltrasi atau penyerangan namun dengan biaya yang cukup tinggi, disisi lain pembangunan obstacle sepanjang garis Pantai dapat menimbulkan kesan provokatif terhadap negara tetangga dan juga akan mengganggu pemandangan wilayah Pesisir Pulau Batam, sehingga perlu dikembangkan obstacle sebagai pertahanan Pantai alami yakni ekosistem mangrove. Untuk memperoleh luasan mangrove secara cepat dan akurat digunakanlah perangkat Google Earth Engine dalam penelitian ini dan menggunakan model Random Forest untuk melakukan ekstraksi informasi mangrove secara sistematis. Berdasarkan hasil ekstraksi diperoleh informasi luasan tutupan mangrove yaitu 2323,7 ha dengan overall accuracy pada model yang dihasilkan adalah 95,8%. Verifikasi di lapangan dilakukan untuk mengetahui kondisi nyata di lapangan dan dihasilkan informasi bahwa jenis mangrove yang dominan adalah Rhizopora Mucronata, Rhizopora Apiculata, dan Sonetaria Alba. Ekosistem vegetasi mangrove yang ada di sekitar Pulau Batam dengan didukung substrat dasar Perairan yang mayoritas lumpur, mampu menghambar laju kendaraan pendarat bertipe amfibi dalam sebuah operasi infiltrasi, akan tetapi melihat fakta antara luas tutupan mangrove dan Pulau Batam secara keseluruhan yaitu 2323,7 ha : 39867,6 ha belum proporsional dan membuka celah pertahanan yang perlu ditanggulangi.
Şah I. Abbas ve Sayın Hanî Türkmenleri Örneğinde Tahakküm ve Direniş
Authors: Karadağ Çınar Gülay 
Published: August 2021

Harezm bölgesinde ikamet eden Sayın Hanî Türkmenleri Safevî hükümdarı Tahmasb döneminde Harezm’den göç edip Etrek ve Gürgen nehirleri arasına yerleşmişlerdir. İl yani boy sisteminde hanlar, on beyler ve aksakallar tarafından idare edilmişlerdir. Safevî Devleti ile bağları işledikleri toprağın ya da kullandıkları meranın bedeli olarak ödedikleri vergilerle sınırlı kalmıştır. Kimi zaman da Safevî Şahına sığınan Harezmli Özbek şehzadelerin yanlarına destek kuvvet olarak verilmişlerdir. Sayın Hanî diğer adıyla Yaka Türkmenleri kendilerini Safevîler’in bir parçası olarak görmemiş ve yarı bağımsız bir hayat sürdürmüşlerdir. Bu nedenle Esterâbâd’a atanan ve kendisini devletin sahibi gibi gören Kızılbaş valiler ile anlaşamamışlardır. Ağır vergi yükü altında ezilmeleri ve adaletsiz bir yönetimle karşı karşıya kalmaları nedeniyle Esterâbâd valilerine başkaldırmışlardır. Onların memnuniyetsizliklerinden kaynaklı isyanları Şah Tahmasb döneminde başlayıp uzun yıllar devam etmiştir.
Şah I. Abbas’ın saltanatı Sayın Hanî isyanlarının en yoğun yaşandığı yıllardır. Şah, askeri müdahaleler ve yönetim sisteminde gerçekleştirdiği değişimler ile bu isyanların üstesinden gelmeye çalışmıştır. Bizzat eşlik ettiği seferler kaynaklara Horasan seferleri olarak yansıtılmıştır. Feridun Han’ın Esterâbâd valiliğine atanmasıyla yerel yönetim Türkmen isyanlarıyla baş edebilir hale gelmiş ve şahın doğrudan müdahalesi sona ermiştir. Feridun Han ile birlikte Esterâbâd, şaha sadakatini ispatlayan gulâm valilerin idaresine geçmiştir. Böylece vilayet halkının değişim arzuları sadece yöneticilerin kökeninde hayat bulmuştur. Safevî Devleti’nin isyanlarla mücadele yöntemleri değişmediği gibi halkın rahatsızlıkları da ciddi manada sorgulanmamıştır.
Hydrodynamics of Small Transient Brightenings in the Solar Corona
Authors: Rajhans Abhishek , Tripathi Durgesh , Kashyap Vinay L. 
Published: August 2021

Abstract
Small scale transients occur in the solar corona at much higher frequencies than flares and play a significant role in coronal dynamics. Here we study three well-identified transients discovered by Hi-C and also detected by the EUV channels of the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory. We use 0D enthalpy-based hydrodynamical simulations and produce synthetic light curves to compare with AIA observations. We have modeled these transients as loops of ∼1.0 Mm length depositing energies ∼1023 erg in ∼50 s. The simulated synthetic light curves show reasonable agreement with the observed light curves. During the initial phase, conduction flux from the corona dominates over the radiation, like impulsive flaring events. Our results further show that the time-integrated net enthalpy flux is positive, hence into the corona. The fact that we can model the observed light curves of these transients reasonably well by using the same physics as those for nanoflares, microflares, and large flares, suggests that these transients may have a common origin.
Measuring the Magnetic Origins of Solar Flares, Coronal Mass Ejections, and Space Weather
Authors: Judge Philip , Rempel Matthias , Ezzeddine Rana , Kleint Lucia , Egeland Ricky , Berdyugina Svetlana V. , Berger Thomas , Bryans Paul , Burkepile Joan , Centeno Rebecca , de Toma Giuliana , Dikpati Mausumi , Fan Yuhong , Gilbert Holly , Lacatus Daniela A. 
Published: August 2021

Abstract
We take a broad look at the problem of identifying the magnetic solar causes of space weather. With the lackluster performance of extrapolations based upon magnetic field measurements in the photosphere, we identify a region in the near-UV (NUV) part of the spectrum as optimal for studying the development of magnetic free energy over active regions. Using data from SORCE, the Hubble Space Telescope, and SKYLAB, along with 1D computations of the NUV spectrum and numerical experiments based on the MURaM radiation–magnetohydrodynamic and HanleRT radiative transfer codes, we address multiple challenges. These challenges are best met through a combination of NUV lines of bright Mg ii, and lines of Fe ii and Fe i (mostly within the 4s–4p transition array) which form in the chromosphere up to 2 × 104 K. Both Hanle and Zeeman effects can in principle be used to derive vector magnetic fields. However, for any given spectral line the τ = 1 surfaces are generally geometrically corrugated owing to fine structure such as fibrils and spicules. By using multiple spectral lines spanning different optical depths, magnetic fields across nearly horizontal surfaces can be inferred in regions of low plasma β, from which free energies, magnetic topology, and other quantities can be derived. Based upon the recently reported successful sub-orbital space measurements of magnetic fields with the CLASP2 instrument, we argue that a modest space-borne telescope will be able to make significant advances in the attempts to predict solar eruptions. Difficulties associated with blended lines are shown to be minor in an Appendix.
La pandémie du covid-19 et son impact économique sur le secteur privé de l’enseignement supérieur au Congo Brazzaville
Authors: Makany Luyindula G. Davy , Batchi Macaire , Makany Roger Armand 
Published: August 2021

Les établissements publics et privés d’enseignement supérieur ont été fermés par le gouvernement le 19 mars 2020 suite à l’apparition le 18 mars 2020 au Congo du 3 ème cas de contamination du covid-19. Bien qu’étant en concurrence, ces établissements ont mis en œuvre une stratégie de coopétition en vue d’obtenir du gouvernement la décision de la reprise de leurs activités. Les établissements privés d’enseignement supérieur (EPRES) n’ont malheureusement pas bénéficié de la moindre mesure d’accompagnement de l’État. Une enquête menée auprès des 38 EPRES à partir d’un questionnaire a mis en lumière au moyen de la méthode statistique de l’analyse en composantes principales que les deux charges déterminantes caractérisant l’impact économique sont les charges des gestes barrières puis les charges fixes. Le plan factoriel principal a permis de construire des typologies des EPRES décrivant leur positionnement par rapport à l’impact économique qu’ils ont subi.