bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the Effectiveness of Minimally Invasive Surgical Interventions in Chronic Complicated Forms of Colonic Diverticulitis
Authors: Itkulov A. F. , Ibatullin A. A. , Baikov D. E. , Eybov R. R. , Timerbulatov M. V. 
Published: December 2024

Introduction. Diverticular disease refers to common non-neoplastic diseases of the colon, accounting for 30–60% of all pathologies of the organ. According to clinical guidelines, the treatment strategy for complicated forms of diverticulitis is predominantly conservative. However, certain forms of chronic complicated diverticulitis require surgical intervention, particularly sigmoid resection.Materials and methods. The study involved a retrospective analysis of robot-assisted, laparoscopic, and open sigmoid resections for chronic complicated forms of diverticular disease of the colon. From 2014 to 2023, a total of 85 patients underwent surgery at the Clinic of Bashkir State Medical University. In Group 1, 24 patients (28.3%) underwent surgery, in Group 2 — 28 patients (32.9%), and in Group 3 — 33 (38.8%). The results were processed using mathematical statistical methods, MS Excel XP, and Statistica 10.0 software.Results and discussion. The comparative analysis of minimally invasive surgical interventions and open surgeries revealed that the application of minimally invasive surgery, specifically robot-assisted and laparoscopic approaches, is associated with reduced hospital stay and fewer postoperative complications compared to similar metrics observed with open surgical procedures.Conclusion. The study findings indicate the advantages of robot-assisted surgeries in certain cases, which, as an alternative method, do not fall short of traditional laparoscopic surgical techniques. Moreover, robot-assisted interventions are associated with earlier postoperative recovery and reduced hospital stay.
Effectiveness of Biological and Surgical Sampling for Detection of Mycobacterium Tuberculosis
Authors: Islamov R. N. , Sharipov R. A. , Tukfatullin R. K. , Sidorov I. V. , Yagafarova R. K. 
Published: December 2024

Introduction. Tuberculosis remains a significant public health issue, ranking second only to COVID-19 in terms of mortality from infectious diseases, with more than 10 million individuals affected annually. Despite a decline in incidence rate, its diagnosis continues to be challenging, particularly in cases with negative results from microbiological and histological examinations.Aim. To compare the effectiveness of surgical diagnostic methods for tuberculosis during the pre-analytical phase of bacteriological verification.Materials and methods. The retrospective study, conducted at the Republican Clinical Tuberculosis Treatment Dispensary of the Republic of Bashkortostan, analyzed data from 1272 patients who were hospitalized in the Tuberculous Pulmonary Surgery Unit from 2021 to 2023 and underwent bacteriological diagnostics, including microscopy and polymerase chain reaction.Results and discussion. The results indicate that out of 1272 surgeries, 65.2% involved resection procedures, with confirmed tuberculosis infection in 83.1% of patients. Bronchoalveolar lavage identified mycobacteria in 153 patients (20.5%), whereas sputum collection revealed them in 106 patients. The new collection method, although less effective, demonstrated a detection rate of 15.7% through molecular genetic analysis.Conclusion. Surgical diagnostic methods for tuberculosis appeared to be effective, detecting mycobacterium tuberculosis in 83.1% of cases, surpassing the standard sputum collection method, which has a detection rate of 10.8% via molecular genetic analysis. Bronchoalveolar lavage proved to be more productive, yielding 20.5% positive results on a molecular genetic basis, 11% microscopically, and 8% through culture. Although the new method is less effective, it is recorded as being more accurate than the standard, with detection rates of 15.7% molecularly, 6.6% microscopically, and 5.2% through culture.
Cicatricial Tracheal Stenosis — A Long-Life Journey
Authors: Pechetov A. A. , Vishnevskaya G. A. , Volchanski D. A. , Lednev A. N. , Danilov I. I. , Gulova N. V. 
Published: December 2024

Introduction. Since ancient times tracheostomy is known as a surgical procedure that ensures airway patency. According to current views, a non-idiopathic cicatricial tracheal stenosis develops within six weeks following the initiation of mechanical ventilation. When a patient presents with a characteristic history and complaints, the diagnosis of cicatricial tracheal stenosis poses no challenges.Aim. To present a series of observations of patients who underwent tracheostomy in childhood, whereas the cicatricial tracheal stenosis was diagnosed only in over 35 years after the onset of airway obstruction symptoms.Materials and methods. The study involved five patients (two men and three women) aged between 43 and 63 years. All patients had undergone tracheostomy in childhood, followed by subsequent decannulation. For over 35 years, the patients were monitored under the diagnosis of bronchial asthma. When a tracheal stenosis was identified, all patients underwent circular tracheal resection.Results and discussion. The duration of the surgical procedure ranged from 110 to 240 minutes. No complications that required re-surgery were recorded. All patients achieved healing of the tracheal anastomosis. The postoperative hospitalization period ranged from 10 to 15 days. The incidence of tracheal complications remains 0.2%–25%. The clinical onset of tracheal stenosis typically occurs within the first few months following decannulation. Functional diagnostic methods reveal a pattern of bronchial obstruction, which necessitates the administration of inhalation therapy using various groups of bronchodilator and anti-inflammatory medications. The most informative instrumental diagnostic techniques for tracheal diseases include laryngotracheoscopy and computed tomography.Conclusion. A history of tracheostomy or mechanical ventilation in patients presenting with complaints of dyspnea requires meticulous attention due to the risk of the development of cicatricial tracheal stenosis.
Safety of the Off-Label Use of Antitumor Drugs in Real Clinical Practice: Experience of Oncologists of the Russian Federation
Authors: Каrabina E. V. , Sakaeva D. D. , Lipatov O. N. 
Published: December 2024

Introduction. One of the key issues associated with the off-label use of antitumor drugs is safety. Typically, the advantages of such prescriptions in oncology are linked to the potential clinical benefits outweighing the risks of complications.Aim. To assess the safety of the off-label antitumor drug therapy in comparison with the on-label drug administration in the context of real clinical practice among oncologists in the Tula region.Materials and methods. The study was conducted at the Tula Regional Clinical Oncology Center, Russia. Over a six-month period in 2019, clinical data, provided by the regional information system, were analyzed for 919 completed treatment cases of 201 patients over 18 years of age who received antitumor drug therapy for malignant neoplasms. The study enrolled patients who had at least one hospitalization and got off-label antitumor drug therapy, as well as those receiving on-label drug treatment. The study assessed the safety of the off-label antitumor drug therapy in comparison with that of the on-label treatment, estimating the frequency of adverse events (AEs), spectrum of adverse events, severity of adverse events, fatal outcomes, treatment delays and discontinuations, and hospitalizations due to toxicity. A comparative analysis involved the results of using off-label and on-label antitumor drug therapy in terms of the aforementioned parameters. Results and discussion. No unforeseen adverse events were revealed in the study. The spectrum of adverse events encompassed 40 clinical and laboratory abnormalities with varying frequencies across the studied groups. Adverse events were observed in the majority of patients across both studied groups (83% and 86%). A predominance of grade I and II toxicity was noted. In some instances, therapy was discontinued and treatment was suspended; however, the frequency of these occurrences was significantly lower compared to current literature data. One fatal outcome due to complications from the administered therapy was recorded. All adverse events were reported in both studied groups with similar frequencies. The most commonly observed adverse events in both groups included hepatotoxicity, anemia, thrombocytopenia, nephropathy, cephalalgia, leukocytosis, skin toxicity, dyslipidemia, hypertension, bone pain syndrome, and dizziness. Other adverse events occurred sporadically with similar frequency. The most severe presentations were noted in the following adverse events: thrombocytopenia, gastrointestinal toxicity, leukocytosis, hyperglycemia, and immune-mediated diabetes mellitus with ketoacidotic coma.Conclusion. In real clinical practice, the safety of off-label and on-label antitumor drug therapy reveals no significant difference.
DIAGNOSTICS OF THE DEGREE OF BLOOD LOSS BY THE METHOD OF STATISTICAL ANALYSIS OF MAPS OF OPTICAL ACTIVITY OF THE POLYCRYSTALLINE COMPONENT OF BIOLOGICAL TISSUES AND FLUIDS
Authors: Shylan Kyrylo 
Published: December 2024

The research was conducted to create a reliable and accurate approach to determining the volume of blood loss, which will allow forensic experts to increase objectivity and accuracy in establishing the causes and circumstances of death, as well as assessing the degree of traumatic injuries, and will help ensure more reliable examination results in forensic practice.
The aim of the work is to develop and evaluate the effectiveness of a method for differential diagnosis of the degree of blood loss in corpses using statistical analysis of optical activity maps of the polycrystalline component of biological tissues and fluids.
Material and methods. The study material was brain, kidney and blood samples (n=124) from corpses aged 18 to 60 years with a previously known blood loss volume from 0mm3 to 2500mm3. The study was conducted using the method of multiparametric differential Muller matrix tomography, which allows detecting changes in the structure of polycrystalline elements of biological tissues at different degrees of blood loss. Calculation of digital values was performed using a laser polarimeter of a standard scheme, further statistical processing was performed using MS® Excel® 2010™ and Statistica® 7.0 software.
Results. For all studied biological samples, the method demonstrates high sensitivity in the range of blood loss volume from 0 мм³ to 1500 мм³ with an accuracy level of 86%-92%. Within the range of blood loss volume from 2000 мм³ to 2500 мм³ the accuracy of the method decreases to 56%-68%. The maximum level of accuracy is achieved for statistical parameters of kidney samples (SM4↔86%-92%), brain (SM4↔86%-90%) and blood films (SM2↔90%-92%), which characterize the Muller matrix maps of circular birefringence.
Conclusions. Based on the conducted study, the high efficiency of the multiparametric Muller matrix differential tomography method in determining the degree of blood loss within the volume of lost blood ∆V=0mm3÷1500mm3 was established. The obtained results demonstrate that this method allows for an objective assessment of structural changes in biological tissues and fluids caused by blood loss. This makes it a unique tool for objectively determining the volume of blood loss.
Sosialisasi Pengelolaan Hama Tanaman Bawang Merah (Allium ascalonicum L.) Dataran Tinggi dengan Cara Menerapkan Sistem Budidaya Tanaman yang Baik di Desa Pasigaran, Kecamatan Tanjungsari, Kabupaten Sumedang, Jawa Barat
Authors: Rasiska Siska , Suminar Erni , Nuraini Anne , Yuniarti Anni , Setiawan Iwan 
Published: December 2024

Desa Pasigaran terletak di Kecamatan Tanjungsari, Kabupaten Sumedang dengan ketinggian tempat 979 meter di atas permukaan laut. Pengunaan lahannya didominasi oleh lahan sawah, lahan kering, dan permukiman. Lahan kering dan pekarangan di permukiman berpotensi dikembangkan sebagai lahan tanaman bawang merah yang memiliki nilai kelayakan usahatani yang tinggi.Salah satu kendala produksi tanaman bawang merah adalah serangan hama, yang dapat diatasi salah satunya dengan praktik budidaya tanaman bawang yang baik. Kegiatan pengabdian ini bertujuan untuk mensosialisasikan hama utama tanaman bawang merah dan mempraktikkan cara pengendaliannya. Pendekatan yang dilakukan dalam kegiatan pengabdian ini adalah 1) diskusi berupa tukar pikiran mengenai nilai penting tanaman bawang merah dan masalah-masalah umum dalam usahatani bawang merah; 2) penyuluhan mengenai hama utama tanaman bawang merah dan cara pengendaliannya; serta 3) pelatihan mengenai praktik budidaya tanaman bawang yang baik. Kegiatan pengabdian ini melibatkan sekelompok wanita tani yang berjumlah 20 orang. Berdasarkan hasil diskusi menunjukkan para peserta belum mengetahui secara tepat nilai ekonomi, sosial, dan budaya dari tanaman bawang merah di Indonesia, namun mengetahui sebagian manfaat dari tanaman tersebut. Selain itu, para peserta tidak mengetahui hama utama tanaman bawang merah dan cara pengendaliannya . Hasil pengabdian menunjukkan bahwa sebagian besar peserta dapat mengikuti semua kegiatan dengan baik, terutama ketika dialog, penyuluhan dan praktek secara langsung di lapangan. Kegiatan inimampu 1) meningkatkan pengetahuan mengenai praktik budidaya tanaman bawang yang baik; 2) meningkatkan kewaspadaan terhadap hama utama tanaman bawang; dan 3) meningkatkan ketrampilan dalam mengendalikan hama tanaman bawang merah.
Pengkayaan Kotoran Sapi dengan Penambahan Orgadek, EM4 dan Molase Untuk Meningkatkan Kulitas Kompos Di Desa Pajagan, Kecamatan Cisitu Kabupaten Sumedang
Authors: Suriadikusumah Abraham 
Published: December 2024

Kotoran sapi pada umumnya dipandang sebagai suatu limbah bagi lingkungan, apabila di buang begitu saja ke lahan atau perairan umum, tanpa melalui pengelolaan yang memadai. Dengan pembuatan kompos, limbah organik berupa kotoran sapi dapat dimanfaatkan menjadi material yang berguna untuk lingkungan, terutama untuk menunjang sektor pertanian. Kotoran sapi sudah lama dikenal sebagai bahan utama pembuatan kompos, bahan ini tersedia cukup banyak di beberapa sentra peternakan. Untuk meningkatkan kualitas kompos yang dihasilkan, telah dilakukan penambahan beberapa bahan lain, seperti Orgadek, EM4 dan Molase. Metode ini terbilang baru dan belum banyak dilakukan oleh petani. Pembuatan kompos ini telah diaplikasikan dalam kegiatan pengabdian masyarakat di Desa Pajagan, Kecamatan Cisitu - Kabupaten Sumedang, pada bulan Juli 2023. Kegiatan ini diharapkan dapat menambah pemahaman khususnya petani, dalam usaha meningkatkan produksi pertaniannya melalui penggunaan kompos yang lebih “baik”. Metode pengabdian masyarakat dilakukan melalui pemaparan oleh tim, berupa: (1) maksud, tujuan, dan pembuatan kompos yang diperkaya; (2) penjelasan tentang bahan-bahan yang digunakan (kotoran sapi, Orgadek, EM4 dan Molase), peran dan manfaat dari masing-masing bahan; (3) tatacara pelaksanaan pembuatan kompos di lapangan/di kebun; (4) diskusi dan tanya jawab dengan peserta/petani; dan diakhiri dengan demonstrasi pembuatan kompos sapi yang diperkaya di lapangan diikuti oleh masyarakat/petani.Kegiatan pembuatan kompos yang diperkaya ini diharapkan, petani dapat membuat dan mengaplikasikannya pada lahan-lahan pertanian mereka guna meningkatkan hasil pertanian yang lebih baik atau lebih tinggi di bandingkan dengan kompos kotoran sapi biasa.
THE CREATIVE WORLD OF GEVORG DEVRIKYAN
Authors: Yerkanyan Anna 
Published: December 2024

The present article presents the general description of the creative work of Gevorg Devrikyan, one of the original figures of the new period of Armenian prose of the 20th century. The article provides an overview of the works of writers of the 1960-80s, indicates their place and role in the Armenian literature, as well as highlights the significance of the creative work of Gevorg Devrikyan. The connection between G. Devrikyan’s works and outstanding figures of the Armenian culture is emphasized, and the problem of aestheticization of history is also presented. The works of the first period of the creative work of the writer, essays and stories, novels and historical novels, the collections of stories on historical and satirical themes are listed, indicating their place and role in the Armenian Soviet prose.
Gevorg Devrikyan’s historical novels, which occupy a special place among the Armenian Soviet historical novels, have been also emphasized. The issues raised in these historical novels are relevant and portray the contemporary life. The importance of G. Devrikyan's historical novels, their educational and didactic nature, as well as the vivid manifestation of patriotism in them are emphasized.
The article also examines the writer's popular and scientific works, stressing the author's great contribution to this area. When reading popular and scientific works and articles, it is immediately noticeable that they came from the writer’s pen: when considering any issue or phenomenon, in addition to the conclusion itself, artistic summaries are presented here, and the portraits of great figures of the Armenian history and culture develop into artistic images. An important place is given to the work “The Great Armenian Figures”, intended for the readers being interested in the Armenian history, literature and culture.
The article also examines the collections of stories based on the medieval evidences. Depicting medieval copyists and manuscript illustrators in almost all of his works, G. Devrikian describes the conditions under which medieval parchment scrolls, tags (chants) and antunis (songs of homeless) were copied and created.
Возможности использования данных группировки спутников ДЗЗ стран БРИКС для решения тематических задач получения информации о лесных экосистемах
Authors: Иванов С.В. , Сидоренков В.М. , Ачиколова Ю.С. , Астапов Д.О. , Тищенко П.А. , Буряк Л.В. , Рыбкин А.С. 
Published: December 2024

В статье рассмотрены различные методы тематического дешифрирования для получения информации о лесах на основе данных группировки спутников дистанционного зондирования Земли стран БРИКС. Представленное исследование является частью работы, выполненной в рамках соглашения между государственной корпорацией «Роскосмос», Индийской организацией космических исследований, Китайской национальной космической администрацией и Южноафриканским национальным космическим агентством. В рамках проекта предоставлена съемка со спутников Китая, Бразилии и Индии для территории пилотного полигона, расположенного на территории Шушенского и Ермаковского районов Красноярского края и Таштыпского района Республики Хакасия. Результаты исследования показали возможность определения лесных и нелесных территорий, количественных и качественных показателей лесов по спектрально-отражательным характеристикам насаждений съемки со спутников Метеор-М и Resourcesat/LIS.
The article discusses various methods of imagery data thematic interpretation for obtaining information about forests based on data from the BRICS countries constellation of remote sensing satellites. The presented research is a part of the work performed within the framework of an agreement between the Russian Space Agency, Indian Space Research Organization, China National Space Administration and South African National Space Agency. Within the project, satellite imagery from China, Brazil and India was provided for the pilot site, located on the territory of the Shushensky and Ermakovsky districts of the Krasnoyarsk Territory and the Tashtypsky district of the Republic of Khakassia. The study results showed the possibility of determining forest and non-forest areas, quantitative and qualitative forests indicators based on the spectral and reflective characteristics taken from Meteor-M and Resourcesat/LIS satellite imagery.
Оценка хозяйственно ценных признаков сортов хеномелеса (Chaenomeles Lindl.) при интродукции в условиях Москвы
Authors: Локонова А.А. , Макаров С.С. , Крючкова В.А. , Бахман В.Ю. 
Published: December 2024

В расширении ассортимента культурных растений для сохранения и оздоровления городской среды важную роль играет интродукция сортов, форм и видов из других географических районов. Представители рода Хеномелес (Chaenomeles Lindl.) являются высокоценными в пищевом, лекарственном и декоративном отношении, красивоцветущими кустарниками, неприхотливыми и устойчивыми к условиям городской среды, к болезням и вредителям. Приведены результаты исследований по изучению 20 сортов хеномелеса, интродуцированных на территории Главного ботанического сада им. Н.В. Цицина РАН (Москва). Сделан анализ визуальных наблюдений за сезонным развитием сортов хеномелеса в возрасте 2–3 лет. Все исследуемые сорта хеномелеса относятся к I и II группам по критерию жизнеспособности. Наилучшей зимостойкостью и более ранним сроком начала цветения отличаются 7 сортов хеномелеса (Pink Storm, Andenken an Karl Ramcke, Red Joy, Fire Dance, Brilliant, Cido, Jet Trail), перспективных для выращивания в природно-климатических условиях Москвы.
The introduction of varieties, forms and species from other geographical areas plays an important role in expanding the range of cultivated plants for the preservation and improvement of the urban environment. Representatives of the genus Chaenomeles Lindl. are highly valuable in nutritional, medicinal and ornamental terms, beautifully flowering shrubs, unpretentious and resistant to urban conditions, diseases and pests. The results of research on the study of 20 Chaenomeles cultivars introduced on the territory of the Tsytsin Main Moscow Botanical Garden of Russian Academy of Sciences (Moscow, Russia). The results of visual observations of the seasonal development of Chaenomeles cultivars at 2-3 years of age are analyzed. All the studied Chaenomeles cultivars belong to groups I and II according to the viability criterion. 7 cultivars of chaenomeles (Pink Storm, Andenken an Karl Ramcke, Red Joy, Fire Dance, Brilliant, Cido, Jet Trail) are distinguished by the best winter hardiness and earlier start of flowering, which indicates its prospects for cultivation in the natural and climatic conditions of the Moscow.
Информационные инструменты в области лесных генетических ресурсов: от международного опыта к национальным решениям (обзор)
Authors: Паленова М.М. , Крутовский К.В. 
Published: December 2024

В статье представлен обзор современных международных инструментов и подходов к управлению лесными генетическими ресурсами. Рассматриваются ключевые международные инициативы и инструменты, направленные на сбор, хранение и анализ данных о генетическом разнообразии лесов, а также оценку угроз для различных видов деревьев. Обсуждаются возможности адаптации и использования этих инструментов в России, принимая во внимание уникальные природные условия и масштабы лесных территорий. На основе проведенного анализа сформулированы рекомендации по созданию национальных инструментов, учитывающих международный опыт и адаптированных к российским условиям.
The article provides an overview of contemporary international tools and approaches to managing forest genetic resources. Key international initiatives and instruments aimed at collecting, storing, and analyzing data on forest genetic diversity are examined, as well as assessing threats to various tree species. The possibilities for adapting and applying these tools within the Russian context are discussed, taking into account Russia’s unique natural conditions and vast forested territories. Based on the analysis conducted, recommendations are formulated for creating national tools that take into account international experience and are adapted to Russian specifics.