bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Medication Adherence Through Adaptive Digital Interventions (iMedA) in Patients With Hypertension: Protocol for an Interrupted Time Series Study
Authors: Etminani Kobra , Göransson Carina , Galozy Alexander , Norell Pejner Margaretha , Nowaczyk Sławomir 
Published: March 2021

Background
There is a strong need to improve medication adherence (MA) for individuals with hypertension in order to reduce long-term hospitalization costs. We believe this can be achieved through an artificial intelligence agent that helps the patient in understanding key individual adherence risk factors and designing an appropriate intervention plan. The incidence of hypertension in Sweden is estimated at approximately 27%. Although blood pressure control has increased in Sweden, barely half of the treated patients achieved adequate blood pressure levels. It is a major risk factor for coronary heart disease and stroke as well as heart failure. MA is a key factor for good clinical outcomes in persons with hypertension.

Objective
The overall aim of this study is to design, develop, test, and evaluate an adaptive digital intervention called iMedA, delivered via a mobile app to improve MA, self-care management, and blood pressure control for persons with hypertension.

Methods
The study design is an interrupted time series. We will collect data on a daily basis, 14 days before, during 6 months of delivering digital interventions through the mobile app, and 14 days after. The effect will be analyzed using segmented regression analysis. The participants will be recruited in Region Halland, Sweden. The design of the digital interventions follows the just-in-time adaptive intervention framework. The primary (distal) outcome is MA, and the secondary outcome is blood pressure. The design of the digital intervention is developed based on a needs assessment process including a systematic review, focus group interviews, and a pilot study, before conducting the longitudinal interrupted time series study.

Results
The focus groups of persons with hypertension have been conducted to perform the needs assessment in a Swedish context. The design and development of digital interventions are in progress, and the interventions are planned to be ready in November 2020. Then, the 2-week pilot study for usability evaluation will start, and the interrupted time series study, which we plan to start in February 2021, will follow it.

Conclusions
We hypothesize that iMedA will improve medication adherence and self-care management. This study could illustrate how self-care management tools can be an additional (digital) treatment support to a clinical one without increasing burden on health care staff.

Trial Registration
ClinicalTrials.gov NCT04413500; https://clinicaltrials.gov/ct2/show/NCT04413500

International Registered Report Identifier (IRRID)
DERR1-10.2196/24494
Risk Factors of Cholera Transmission in Al Hudaydah, Yemen: Case-Control Study
Authors: Qaserah Abdulqawi Mohammed , Al Amad Mohammed Abdullah , Al Serouri Abdulwahed Abduljabbar , Khader Yousef Saleh 
Published: March 2021

Background
Yemen has recently faced the largest cholera outbreak in the world, which started at the end of 2016. By the end of 2017, the cumulative reported cases from all governorates reached 777,229 with 2134 deaths. Al Hudaydah was one of the most strongly affected areas, with 88,741 (18%) cases and 244 (12%) deaths reported.

Objective
The aim of this study was to determine the risk factors associated with cholera transmission in Al Hudaydah city, Yemen.

Methods
From December 1, 2017 to January 10, 2018, a total of 104 patients with cholera (57 women and 47 men) who presented at cholera treatment centers in Al Hudaydah city with three or more watery stools in a 24-hour period and with moderate or severe dehydration were identified for inclusion in this study. Each case was matched by age and gender with two controls who were living in the neighboring house. A semistructured questionnaire was used to collect data on behavioral and environmental risk factors such as drinking water from public wells, storing water in containers, consumption of unwashed vegetables or fruits, and sharing a toilet.

Results
The median age of the cases and controls was 20 years (range 5-80) and 23 years (range 5-85), respectively. Only 6% of cases and 4% of controls were employed. Multivariate analysis showed that eating unwashed vegetables or fruits (odds ratio [OR] 7.0, 95% CI 1.6-30.6, P=.01), storing water in containers (OR 3.0, 95% CI 1.3-7.3, P=.01), drinking water from a public well (OR 2.5, 95% CI 1.1-5.7, P=.02), and using a public toilet (OR 5.2, 95% CI 1.1-24.4, P=.04) were significantly associated with cholera infection risk.

Conclusions
The cholera transmission risk factors in Al Hudaydah city were related to water and sanitation hygiene. Therefore, increasing awareness of the population on the importance of water chlorination, and washing fruits and vegetables through a health education campaign is strongly recommended.
IN VITRO ANTIOXIDANT AND IN VIVO ANTIDIABETIC ACTIVITY OF TWO POTENTIAL PROBIOTIC ENTEROCOCCUS SPP. ON ALLOXAN-INDUCED DIABETIC RATS
Authors: RAJPUT KAMNI , CHANDRA DUBEY RAMESH 
Published: March 2021

Objective: In vitro antioxidant activity, in vivo antidiabetic property and intestinal attachment by two potential probiotic bacterial strains, namely, Enterococcus faecium and Enterococcus hirae were studied using albino rats.
Methods: Antioxidant the activity was assessed using 2,2-Diphenyl-1-picrylhydrazyl radicals scavenging assay. Alloxan was administered intraperitoneally to induce diabetic conditions in experimental rats. Animals were treated with oral administration of Enterococcus spp., such as E. faecium, and E. hirae isolated from goat and sheep milk. The control animal group received normal saline for the same days. Glibenclamide drug was used as a positive control against probiotic bacterial cells.
Results: However, administration of probiotic bacterial strains E. faecium and E. hirae, in albino rats significantly (p<0.05) at varying doses lowered blood glucose levels in diabetic rats as compared to the diabetic control group. Both the species of Enterococcus increased the bodyweight of experimental rats. However, E. faecium was the best antidiabetic strain having the antioxidant activities also in comparison to E. hirae. The attachment of probiotic bacterial cells E. faecium on the rat’s intestine wall against pathogens was examined. Furthermore, E. faecium showed its aggregation with pathogens by attachment of the intestines of albino rats. This showed that both the bacterial strains exhibited in vivo antidiabetic effect.
Conclusion: The results of this study showed that probiotic bacteria possess antioxidant, antidiabetic activities, and attachment of intestine.
ANTIFUNGAL ACTIVITY OF ACTINOBACTERIA WITH A POTENTIAL TO INHIBIT RICE BLAST FUNGUS MAGNAPORTHE ORYZAE (ANAMORPH PYRICULARIA ORYZAE)
Authors: R THILAGAM , R BALAGURUNATHAN , M SANGEETHA , N HEMALATHA 
Published: March 2021

Objective: The aims of the present study were to screen the actinobacteria with high potential ability to produce secondary metabolites that have inhibitory activity against plant pathogenic fungi, Magnaporthe oryzae. Production of secondary metabolites was analysis by thin-layer chromatography and bioautography assay.
Methods: Screening and selection of potential Streptomyces sp. morphological, cultural, physiological, and biochemical characterization of the screened isolate was carried out. Antifungal compound was confirmed by bioautography assay.
Results: Bioautography method use in this study was found to be antifungal fraction from the crude extract. Antifungal secondary metabolites can be readily located on the plates by observing clear zones where active compounds inhibit fungal growth.
Conclusion: The bioautography assay shows that this isolates can produce antifungal compound. Therefore, this isolate proves to be a promising microbe which can be further studied for its applications a biocontrol agent against rice blast fungi.
DRUG-RELATED PROBLEMS AND ITS PRESCRIBING INDICATORS IN STROKE PATIENTS: A PROSPECTIVE OBSERVATIONAL STUDY
Authors: THAMMISETTY DURGA PRASAD , RANGANAYAKULU DIVITI , NAYAKANTI DEVANNA 
Published: March 2021

Objective: The objective of the study was to assess the drug-related problems (DRPs) and the World Health Organization (WHO) core prescribing indicators among stroke patients.
Methods: A prospective observational study was conducted among stroke inpatients of Acute Medical Care and General Medicine Department of a tertiary care hospital located in Tirupati, Andhra Pradesh, India. A suitable data collection form was used to collect the data about demographics, clinical characteristics, WHO prescribing indicators, and DRPs. Descriptive statistics were used to represent the demographics, distribution of DRPs, and prescribing indicators in the study. Chi-square test was employed to test the significant association between the demographics and the occurrence of DRPs.
Results: Among 174 patients included in the study, 89 had one or more DRPs. A total of 122 DRPs were identified in the study population. Drug interactions (48.4%) and adverse drug reactions (ADRs) (17.2%) were commonly observed DRPs. A significant direct association was observed between the occurrence of DRPs and number of comorbidities (p<0.001), polypharmacy (p<0.001), and hospital stay (p<0.05). The average number of drugs per prescription was 7.2. Of drugs prescribed, 67.6% were in their generic names. The percentage of encounters in which an antibiotic, injection was prescribed was 65.5% and 89.6% respectively. The percentage of drugs prescribed from an essential drug list was 91.2%.
Conclusion: The rate of drug interactions and ADRs was high in treatment of stroke patients. Patients suffering from comorbidities, polypharmacy, and long hospital stay were positively associated with occurrence of DRPs in stroke. Regular monitoring and screening for drug interactions and ADRs were advised to reduce the burden DRPs in stroke patients admitted in a critical care unit.
ANALISIS PELATIHAN TERHADAP PENGEMBANGAN KARYAWAN PADA PT SURYA TOTO INDONESIA UNIT SERPONG BAGIAN WAREHOUSE
Authors: Jamaludin Pusporini Palupi 
Published: March 2021

Penelitian ini bertujuan untuk mengetahui Pelatihan dan Pengembangan Karyawan di PT Surya Toto Indonesia Unit Serpong Bagian Warehouse, dan juga untuk mengetahui analisis pelatihan karyawan terhadap Pengambangan karyawan karyawan PT Surya Toto Indonesia Unit Serpong Bagian WarehouseMetode penelitian yang digunakan dalam penelitian ini menggunakan metode pendekatan kualitatif, dengan model penelitian yaitu fenomenologi. Sumber data yang digunakan adalah sumber data primer dan sekunder dan teknik sampling yang digunakan dalam penelitian ini adalah teknik purposive samping Dalam penelitian kualitatif peneliti memiliki subyek penelitiannya tidak lebih dari sepuluh sampel. Adapun ciri khas dari wawancara mendalam ini didasarkan oleh sampel yang totalnya sebanyak sepuluh orang. Hal ini ditunjukkan jumlah informan utama sebanyak tujuh orang dan trigulasi sebanyak tiga orang. Metode pengumpulan data menggunakan sumber primer dan sekunder, teknik pengumpulan data dengan cara observasi, wawancara, studi dokumentasi dan gabungan atau triangulasi. Dari penelitian yang dilakukan dan hasil yang diperoleh maka dapat disimpulkan : Hasil observasi peneliti dan hasil wawancara bersama para karyawan yang peneliti jadikan informan utama dan para pimpinan yang dijadikan sebagai trigulasi yaitu Pelatihan bagi perusahaan merupakan aktivitas yang penting dilakukan, di mana hal ini akan dapat mempengaruhi tingkat hasil kinerja dan prestasi kerja bagi tenaga kerja itu sendiri dan organisasi atau perusahaan di mana tenaga kerja tersebut bekerja.
ВМІСТ ХЛОРОФІЛІВ І КАРОТИНОЇДІВ У ПАГОНАХ ЛОХИНИ ВИСОКОРОСЛОЇ (VACCINIUM CORYMBOSUM L.)
Authors: Yavorska N. J. , Vorobets N. M. 
Published: March 2021

Since photosynthetic pigments are not only important for plants in photosynthesis,they are also biologically active substances in therapeutic usage, the search for plants with their high content remains an urgent task of nutraceuticals, pharmacy and medicine. In this study, the shoots of Vaccinium corymbosum L. varieties Bluejay (early ripening) and Bluecrop (medium ripening) grown in the experimental area in the Lviv region of Ukraine in the phenological phases: in flowering, fruiting, after fruiting, in preparation for winter dormancy have been used. 100 % acetone, 80 % acetone and diethyl ether were used as extractants. The content of chlorophylls and carotenoids was determined spectrophotometrically at wavelengths corresponding to their absorption maxima and calculated by formulas Holm-Wettstein, Lichtenthaler, Wintermans and de Mots.
The findings of the study show that the content of chlorophyll a and b in the shoots of V. corymbosum depends on the extractant and the phenological phase of growth at which the plant material is collected. The best extractant was 100 % acetone, slightly worse 80 % acetone and diethyl ether, although in general the level of chlorophylls coincided. All of the extractants used were effective enough to remove carotenoids. The content of chlorophylls and carotenoids and their ratio in the shoots of investigated varieties of V. corymbosum is high and varies during the growing season: the highest content of chlorophylls is observed during flowering: 45.45±7.384 and 37.89±2.849 mg/100 g of dry weight in Bluejay and Bluecrop respectively. The content of carotenoids increases from the flowering phase to fruiting and remains at the same level long after its completion. The highest content of carotenoids was 5.49±0.451 and 5.73±0,143 mg/100 g of dry weight in Bluejay and Bluecrop respectively. It is assumed that the dynamics of chlorophyll content reflects the increase in the level of energy needs of the plant to ensure generative reproduction during the fruiting phase, followed by preparation for changes in temperature and insolation in winter. Some evidence of this may be the increase in the ratio of chlorophylls a/b during this period.
In our opinion, further research on the use of P as a medicinal raw material would be beneficial, taking into account the given results.
Analysis of the Application of Blockchain Technology in the Field of Supply Chain Finance in the Natural Gas Industry
Authors: Zhang Jianping , Wang Fuping , Pu Yongsong , Li Pu , Ma Yingkai , Li Zizi 
Published: March 2021

Abstract
After China's supply chain finance business has gradually matured in the consumer finance field, it has begun to extend to the industrial finance field. As a branch of industrial finance, the natural gas industry supply chain finance business has gradually developed, and the number of participants has gradually increased. The article mainly introduces the development status of natural gas supply chain financial services in China. Research has found that there are still many problems in the current industry development, such as the inability of effective collaboration among participants, and the inability to unify logistics, information flow, capital flow and energy flow in the industry. On this basis, the article studies the methods of blockchain technology to solve corresponding problems, and proposes the application ideas of blockchain technology in the field of natural gas supply chain finance, hoping to promote development by constructing a business model business architecture and technical architecture, This model can produce significant economic and social benefits, has a high theoretical feasibility, but there is no concrete examples at present. Finally, suggestions are made in five aspects, including strengthening the design of top-level systems, incorporating energy flows into the supply chain financial framework system, creating an open innovation atmosphere, enhancing technological progress, strengthening core corporate social responsibility, and promoting core corporate organizational innovation.
Produksi Biogas dari Jerami Padi Menggunakan Cairan Rumen dan Kotoran Sapi
Authors: Anwar Hasrul , Widjaja Tri , Prajitno Danawati Hari 
Published: March 2021

Jerami padi adalah salah satu limbah pertanian yang melimpah di Indonesia yang dapat digunakan sebagai sumber lignoselulosa untuk produksi biogas. Salah satu metode untuk meningkatkan produksi biogas adalah dengan menambahkan cairan rumen dan kotoran sapi. Penelitian ini membandingkan produksi biogas pada cairan rumen sapi (JP-R) dan campuran cairan rumen dan kotoran sapi (JP-RKS). Percobaan ini dilakukan dalam reaktor <em>batch</em> anaerob selama 30 hari dengan volume kerja 3,6 L pada suhu mesofilik. Parameter yang diukur pada penelitian ini seperti asam lemak volatil (VFA), <em>Chemical Oxygen Demand</em> (COD), total padatan (TS), volatil padatan (VS), dan komposisi biogas. COD JP-R dan JP-RKS masing-masing adalah 54,21 % dan 49,44%. <em>Yield</em> metana untuk JP-R dan JP-RKS masing-masing adalah 0,48 Nm<sup>3</sup>/kgCOD<sub>removal </sub>dan<strong> </strong>0,015 Nm<sup>3</sup>/kgCOD<sub>removal</sub>. Komposisi biogas pada JP-R adalah 47,97% CH<sub>4</sub>, 7% CO<sub>2</sub> dan 0,44% H<sub>2</sub>, sedangkan pada JP-RKS komposisi biogas adalah 23,34% CH<sub>4</sub>, 10,06% CO<sub>2, </sub> dan 0,39% H<sub>2</sub>.
Biofilm Expressing Genes in Bacteria Causing Urinary Catheter Associated Infections
Authors: Kanimozhi B  , Meenatchi Sundaram S  
Published: March 2021

Biofilm associated infection causes higher mortality in catheterized patients. Identification of cupA gene in Pseudomonas aeruginosa coding for biofilm formation was selected as a primary objective. Synergistic antibacterial drugs (moxifloxacin-metronidazole) were prepared using the selected concentrations for coatings onto urinary catheter samples. Antibacterial coatings of synergistic antibacterial drugs onto a urinary catheter and its antibacterial activity were evaluated using the standard diffusion method. The drug coated catheters were investigated for their biocompatible properties. The biocompatibility of the drug coated samples was investigated on L929 fibroblast cell lines using MTT assay. The biofilm expressing genes (cupA gene) of the selected organism was detected using molecular methods. During the analysis, the cupA gene from the target organism was confirmed by the PCR method aided with the DNA electrophoresis process. The study was confirmed from the obtained DNA fragments of 172bp by comparing with 170bp fragment of reference bacterial strain. Quantitative antibacterial activity results showed that the drug coated catheter samples were significantly reduced the bacterial numbers. Biocompatibility of coated catheter samples evaluated by in-vitro cell culture cytotoxicity assay exhibited no effect on cell viability of fibroblast cell lines. It is concluded that identifying biofilm expressing genes could help the health care workers to diagnose and treat the patients with an appropriate antibacterial agent.
Phytochemical and Pharmacological evaluation of hibiscus hispidissimus griff
Authors: Alekhya V  , Ganapaty S  , Deepan T  
Published: March 2021

To assess phytochemical with pharmacological studies of Hibiscus hispidissimus griff belong to family malavaceae. Preliminary phytochemical analysis reveals the presence of steroids, triterpenes, saponins, steroidal saponins and phenols. Evaluation of anti-inflammatory, anti-microbial with antioxidant action were performed on aerial parts of methanolic extract of Hibiscus hispidissimus. Invitro antioxidant activity was performed by 2, 2 -diphenyl- 1- picrylhydrazyl (DPPH) assay, hydroxy radical scavenging method and superoxide radical scavenging activity.The results of invitro antioxidant study reveal that % inhibition of H. hispidissimus was higher compared to ascorbic acid. Anti-inflammatory studies were performed using carrageenan-induced rat paw oedema animal model, for anti-inflammatory studies, the extracts were compared with standards like indomethacin, and it shows a remarkable zone of inhibition ranging from 58.97 to 71.73 respectively. The anti-bacterial and antifungal activity of plant extracts were studied for the occurrence of inhibition zones. The activity was performed by the cup plate method. Ethanolic extract of H. Hispidissimus shows significant anti-bacterial effect against S. Aureus, B. Subtilis, P. Vulgaris and E. coli using ciprofloxacin (50µg/ml) as standard.The extracts show remarkable inhibition of zone of inhibition, and results were compared with that of standard drugs against the organism tested. In conclusion, the ethanolic extract of H. hispidissimus shows significant antioxidant, anti-inflammatory and anti-bacterial properties.
EFEKTIVITAS PEMBELAJARAN MICROSOSFT EXCEL BERBASIS INTERAKTIF PADA MATA KULIAH TEKNOLOGI INFORMASI DAN KOMUNIKASI (TIK) (Study Kasus Pada Mahasiswa Manajemen STIE PGRI Dewantara Jombang)
Authors: Mutiarni Rita 
Published: March 2021

abstractResearch conducted in STIE PGRI Dewantara on a management course aims determines: 1) the application of Microsoft Excel-based interactive learning course on information and communication technology (ICT), 2) the effectiveness of Microsoft Excel-based interactive learning. This research is a descriptive case study approach. Data were obtained through interviews and questionnaires to 30 over three (3) variables that represent effectiveness, namely: 1) Satisfaction Program, 2) Input and Output Level and 3) The success of the program. The survey results revealed that the Microsoft Excel-based interactive learning course on information and communication technology (ICT) obtaining results of the overall assessment of the effectiveness of 80% under the category of very Effective.Keywords: effectiveness, instructional, interactive, Excel Mirosoft abstrakPenelitian yang dilakukuan di STIE PGRI Dewantara pada program studi manajemen ini bertujuan untuk mengetahu: 1) penerapan pembelajaran Microsoft Excel berbasis interaktif pada mata kuliah teknologi informasi dan komunikasi (TIK), 2) efektivitas pembelajaran Microsoft Excel berbasis interaktif. Jenis penelitian ini adalah deskriptif dengan pendekatan studi kasus. Data diperoleh melalui wawancara dan kuisioner kepada 30 atas 3 (tiga) variabel yang mewakili efektivitas, yaitu: 1) Kepuasan Program, 2) Tingkat Input dan Output dan 3) Keberhasilan program. Dari hasil penelitian diketahui bahwa pembelajaran Microsoft Excel berbasis interaktif pada mata kuliah teknologi informasi dan komunikasi (TIK) memperoleh hasil penilaian efektivitas secara keseluruhan sebesar 80% berada pada kategori sangat efektiv.Kata kunci: efektivitas, pembelajaran, interaktif, Mirosoft Excel
Analisis Laba, Arus Kas Operasi Dan Nilai Buku Ekuitas Terhadap Harga Saham
Authors: Mufidah Eva 
Published: March 2021

abstractParameter to measure the performance of companies in this study is the profit, operating cash flow and book equity. This study aimed to obtain information profit, operating cash flow and book equity of the stock price. The study was conducted by purposive sampling of 40 companies listed on the Stock Exchange during the period 2011-2014. This study uses a quantitative approach to the multiple regression analysis. The analysis showed that profit and operating cash flows have a significant effect on stock prices, while the book equity is not significant effect on stock prices.Keywords: profit, operational cash flow, book equity, share price abstrakParameter untuk mengukur kinerja perusahaan dalam penelitian ini adalah laba, arus kas operasi, dan nilai buku ekuitas.Penelitian ini bertujuan untuk memperoleh informasi laba, arus kas operasi, dan nilai buku ekuitas terhadap harga saham. Penelitian dilakukan secara purposive sampling terhadap 40 perusahaan manufaktur yang terdaftar di BEI selama periode 2011-2014. Penelitian ini menggunakan pendekatan kuantitatif dengan analisis regresi berganda. Hasil analisis menunjukkan bahwa laba dan arus kas operasi berpengaruh signifikan terhadap harga saham, sedangkan nilai buku ekuitas tidak berpengaruh signifikan terhadap harga saham.Kata kunci: laba, arus kas operasi, nilai buku ekuitas, harga saham