bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perbandingan Kepuasan Siswa terhadap Pembelajaran Fisika Sistem Online dengan Menggunakan Smartphone dan Laptop
Authors: Putra Nurhamdin , Syarkowi Ahmad 
Published: November 2021

Penelitian ini bertujuan untuk menganalisis perbandingan kepuasan siswa terhadap pembelajaran fisika secara online antara siswa yang belajar dengan menggunakan smartphone dan siswa yang menggunakan laptop. Jenis penelitian yang dilakukan adalah penelitian kuantitatif dimana metode yang digunakan adalah survei. Pada penelitian ini pengambilan data dilakukan dengan cara membagikan kuisioner kepada responden melalui google formulir. Sampel dalam penelitian ini diambil dengan menggunakan teknik Convenience Sampling dimana siswa tingkat SMA dan MA jurusan IPA dari 8 sekolah di Provinsi Bengkulu yang mengisi kuisioner sebagai sampelnya. Dari kuisioner yang dibagikan diperoleh data sebanyak 525 responden. Data yang diperoleh akan dianalisis dengan menggunakan Uji Mann Whitney dikarenakan data tidak berdistribusi normal. Berdasarkan analisis data yang telah dilakukan diperoleh hasil signifikansi perhitungan p-value sebesar 0,808 lebih besar dari 0,05. Dari hasil ini, dapat dikatakan bahwa tidak terdapat perbedaan yang signifikan antara tingkat kepuasan siswa yang menggunakan Smartphone dan siswa yang menggunakan laptop dalam pembelajaran fisika sistem online. Sehingga, dapat disimpulkan dalam pembelajaran fisika secara online baik siswa yang menggunakan Smartphone maupun laptop memperoleh kepuasan yang hampir sama, dengan tingkat kepuasan terkategori puas. This study aims to compare student satisfaction with online physics learning between students who study using smartphones and students who use laptops. This type of research is quantitative research, where the method used is a survey. In this study, data collection was carried out by distributing questionnaires to respondents via google forms. The sample in this study was taken using the technique Convenience Sampling, where high school and MA level students majoring in science from 8 schools in Bengkulu province filled out questionnaires as samples. From the questionnaires, distributed data obtained as many as 525 respondents. The data obtained will be analyzed using the Mann Whitney test because the data is not normally distributed. Based on the data analysis that has been carried out, the calculation results of the significance of the p-value of 0.808 are greater than 0.05. From these results, it can be said that there is no significant difference between the level of satisfaction of students who use smartphones and students who use laptops in online learning physics. So, it can be concluded that in online physics learning, both students who use smartphones and laptops get almost the same satisfaction, with the level of satisfaction categorized as satisfied.
Social Network-Based Digital Stroke Prevention: Opportunities, Results and Prospects
Authors: Demkina A. E. , Bezzubtseva M. V. , Ryabinina M. N. , Kotlyar Ya. A. , Keln O. L. , Sarapulova А. V. , Zhetishev R. R. , Kuvaev V. S. , Maksimova M. Y. , Pogosova N. V. , Zhetisheva I. V. 
Published: November 2021

Aim. To study the possibilities and limitations of the social network as a digital medical tool, which is aimed at improving programs for primary and secondary stroke prevention in young people.Material and methods. The study was carried out in the format of online training for volunteers. At the first stage of the work, the online school “Stroke in Young People” was announced in 8 medical blogs. As part of the school, a special account was created for readers (n=1354). At the second stage, 49 respondents (4% of men, whose average age was 24.4±5.2 years) were selected from 1354 listeners, who were surveyed on “Awareness of risk factors and stroke symptoms among users of social networks” before and after the online school.Results. The online school audience is predominantly female (91%), and 43% of readers were in the 25-34 age group. The total number of people who listened to and read the online school material is 8712 people. 17% worked in the healthcare system, and 22% of respondents had a history of stroke. 38 (78%) people of the 2nd stage among the respondents independently searched for information about stroke earlier, and 30 (61%) received this information passively from medical workers in 2020. Before the online school start, the majority of respondents (over 60%) were aware of 2 out of 7 stroke risk factors (dyslipidemia and arterial hypertension) and 3 out of 6 stroke signs (drooping of the face half, weakness in the limbs and difficulty speaking). Less than 40% of the participants considered the stroke risk factors for diabetes mellitus, other cardiovascular diseases (CVD), obesity, and alcohol use; less than 20% were aware of stroke symptoms such as impaired vision and coordination and very severe headache. After completing online learning, the greatest increase in knowledge was found among the following risk factors – smoking and other CVDs (p<0.05); stroke symptoms - headache and drooping of the face half (p<0.05).Conclusion. The online school aroused interest among healthcare workers and people without medical education, including those with stroke. Most of the respondents believed that they knew how to prevent a stroke (over 80%) and would be able to provide first aid to a person with a stroke (over 90%). At the same time, the awareness of risk factors and stroke symptoms was low prior to the start of learning, even though the study included healthcare workers and stroke survivors. Online learning has led to increased awareness of some risk factors and stroke symptoms. Social media can be one of the tools for medical prevention of stroke in young people, but program planning should take into account the way the material is presented and its readability.
Pharmacogenetic Aspects of Postoperative Anesthesia with Ketoprofen in Cardiac Surgery Patients
Authors: Morozova T. E. , Shatsky D. A. , Shikh N. V. , Shikh E. V. , Andrushchyshina T. B. , Lukina M. V. , Kachanova A. A. , Sozaeva Z. A. , Shuev G. N. , Denisenko N. P. , Grishina E. А. , Sychev D. A. 
Published: November 2021

Aim. Evaluation of the effect of polymorphisms of the CYP2D6, CYP2C8 genes on the efficacy and safety of postoperative analgesia with ketoprofen in patients with coronary artery disease after cardiac surgery.Material and methods. The study included 90 patients with an established diagnosis of coronary artery disease and postoperative period after cardiac surgery. Patients received ketoprofen 100 mg intramuscularly 2 times a day for 5 days. The intensity of pain was rated by Numeric Rating Scale. The severity of dyspepsia was assessed by the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire. DNA was isolated from venous blood using an automated system. Single nucleotide polymorphisms CYP2C8 (C>T) rs11572080, CYP2D6*4 (1846G>A) rs3892097 were determined by the real-time polymerase chain reaction method.Results. In patients with genotypes GA and GG for the allelic variant CYP2D6*4, significant differences in the intensity of pain syndrome were found on days 4 and 5 of the postoperative period: 3,91±2,17 and 4,95±1,8 points (p=0,04), 3,52±1,95 and 4,5±1,7 points (p=0,04) in patients with GA and GG genotypes on days 4 and 5, respectively. In patients with the CT genotype for the CYP2C8 rs11572080, the severity of dyspepsia by GSRS was significantly higher than in patients with the CC genotype: 22,67±7,64 and 18,97±4,25 points, respectively.Conclusion. Patients with the GA genotype for the CYP2D6*4 allelic variant showed a lower intensity of pain syndrome than the GG genotype. In patients with the CT genotype for the CYP2C8 rs11572080, higher dyspepsia was revealed than in the CC genotype.
New Indicators of Myocardial Work in Healthy Individuals
Authors: Oleynikov V. E. , Babina A. V. , Galimskaya V. A. , Golubeva A. V. , Makarova K. N. , Donetskaya N. A. 
Published: November 2021

Aim. To study in healthy individuals the gender and age characteristics of left ventricular (LV) myocardial work indicators, their correlations with global LV deformity indicators and echocardiographic parameters characterizing LV systolic and diastolic functions.Materials and methods. 70 Healthy individuals (n=70; 34 men and 36 women; aged 39.3±8.9 years) were included in the study. The echocardiographic examination determined the standard parameters and indicators of myocardial work: global work efficiency (GWE), global constructive work (GCW), global wasted work (GWW), global myocardial work index (GWI); as well as the myocardium deformation characteristics: global longitudinal deformation (GLS), global radial deformation (GRS) and global circular deformation (GCS). Spearman's correlation coefficient was used to investigate the relationship between parameters. A correlation was considered weak at r≤0.3, moderate at 0.3<r<0.7, and strong at r≥0.7.Results. The average value of global work efficiency (GWE) in men was 97% (96; 98), in women – 98% (97; 98). Global constructive work (GCW) in men was 2343.8±350.4 mm Hg%, in women – 2362.2±343.8 mm Hg%. The average value of global wasted work (GWW) in men was 46 mm Hg% (27; 75), in women – 44 mm Hg% (33; 55.5). The global myocardial work index (GWI) in men was 2069.9±356.4 mm Hg%, in women – 2055.7±339.9 mm Hg%. No significant differences were found in the comparative analysis of performance indicators. The analysis of correlations found that the myocardial work indicators didn't have significant correlations with age. Ejection fraction was moderately correlated with GWI (r=0.45) and GCW (r=0.49). Global longitudinal strain was strongly correlated with GWI (r=0.77) and GCW (r=0.77). Global radial strain correlated moderately directly with GWI (r=0.4) and GCW (r=0.4). Global circular strain was moderately correlated with GCW (r=0.35). A strong negative correlation was found between the GWE indicator and the post systolic contraction index (PSI) (r=-0.85). At the same time, PSI and GWW had a strong positive correlation (r=0.85).Conclusion. Indicators of LV myocardial work in healthy individuals do not have gender differences. The efficiency of the work of the myocardium depends primarily on the deformation of the LV, while the constructive work is determined by the volume characteristics. The wasted work indicator depends on the number of segments that peak in the post-systolic period.
Intermedin1-53 Inhibits NLRP3 Inflammasome Activation by Targeting IRE1α in Cardiac Fibrosis
Authors: Zhang Lin-Shuang , Zhang Jin-Sheng , Hou Yue-Long , Lu Wei-Wei , Ni Xian-Qiang , Lin Fan , Liu Xiu-Ying , Wang Xiu-Jie , Yu Yan-Rong , Jia Mo-Zhi , Tang Chao-Shu , Han Ling , Chai San-Bao , Qi Yong-Fen 
Published: November 2021

Abstract
Intermedin (IMD), a paracrine/autocrine peptide, protects against cardiac fibrosis. However, the underlying mechanism remains poorly understood. Previous study reports that activation of Nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome contributed to cardiac fibrosis. In this study, we aimed to investigate whether IMD mitigates cardiac fibrosis by inhibiting NLRP3. Cardiac fibrosis was induced by angiotensin II (Ang II) infusion for 2 weeks in rats. Western blot, real-time PCR, histological staining, immunofluorescence assay, RNA sequencing, echocardiography and hemodynamics were used to detect the role and the mechanism of IMD in cardiac fibrosis. Ang II infusion resulted in rat cardiac fibrosis, shown as over-deposition of myocardial interstitial collagen and cardiac dysfunction. Importantly, NLRP3 activation and endoplasmic reticulum stress (ERS) was found in Ang II treated rat myocardium. Ang II infusion decreased the expression of IMD and increased the expression of the receptor system of IMD in the fibrotic rat myocardium. IMD treatment attenuated the cardiac fibrosis and improved cardiac function. In addition, IMD inhibited the upregulation of NLRP3 markers and ERS markers induced by Ang II. In vitro, IMD knockdown by small interfering RNA significantly promoted the Ang II-induced cardiac fibroblast and NLRP3 activation. Moreover, silencing of inositol requiring enzyme 1 α (IRE1α) blocked the effects of IMD inhibiting fibroblast and NLRP3 activation. Pre-incubation with PKA pathway inhibitor H89 blocked the effects of IMD on the anti-ERS, anti-NLRP3 and anti-fibrotic response. In conclusion, IMD alleviates cardiac fibrosis by inhibiting NLRP3 inflammasome activation via suppressing IRE1α and cAMP/PKA pathway.
Ranking the Return on Assets of Tehran Stock Exchange by New Method Based on Z-numbers Data
Authors: Farzam Maryam , kermani Mozhdeh Afshar , Allahviranloo Tofigh 
Published: November 2021

Abstract

Since real-world data is often inaccurate and working with fuzzy data and Z-numbers are very important and necessary, in the real world we need to rank and compare data. In this paper, we introduce a new method for ranking Z-numbers. This ranking algorithm is based on centroid point.We evaluate distance between centroid point, and based on this distance, we rank the Z-numbers.We use this method in two practical examples. First in ranking the return on assets of Tehran stock exchange, and second, in ranking of factors affecting the productivity of tourism security.The advantage of this method over conventional fuzzy methods is considering uncertainty, and allocating credit in the opinion of experts to estimate fuzzy parameters.
In vitro comparison of the cytotoxicity of different endodontic sealers; AH Plus, AdSeal, Endoseal MTA, and GuttaFlow Bioseal
Authors: Dastorani Mehdi , Aliee Muhammad javad , Halabian Raheleh , Solati Mostafa , Alemrajabi Mohammadsadegh 
Published: November 2021

Abstract
Background: This study aimed to assess the cytotoxicity of four commonly used endodontic sealers namely AH Plus, AdSeal, Endoseal MTA, and GuttaFlow Bioseal against human gingival fibroblasts (HGFs). Methods: After culturing the HGFs, they were exposed to the respective sealers in set form and in five different weights, after sterilization. The cytotoxicity of the sealers was evaluated after 1, 3 and 7 days using the methyl thiazolyl tetrazolium (MTT) assay. Data were analyzed by repeated measures ANOVA. Results: After 24 h, all sealers showed low cytotoxicity. However, all sealers in 250 mg and 500 mg weights showed significantly higher cytotoxicity than the negative control group at 72 h, and 7 days (P<0.05) except for AdSeal in 80 mg weight (P>0.05). AH Plus was significantly more cytotoxic than other sealers at 3 and 7 days (P<0.05) while AdSeal had the closest results to the negative control group, and showed significantly higher biocompatibility than other sealers in 250 mg concentration. Conclusion: AdSeal showed the highest biocompatibility while AH Plus had the highest cytotoxicity among the tested sealers. Thus, its application may delay the healing of periapical lesions.
The anti-tumor effect of stigmasterol on sorafenib treated human breast cancer cell lines
Authors: elshamy asmaa , Omran Gamal , Abd-Alhaseeb Mohammad , Houssen Maha 
Published: November 2021

Abstract
Background: Breast cancer is the most common invasive malignancy and the leading cause of tumor-related death among women globally. Excessive angiogenesis, sustained proliferation, and evasion of apoptosis are crucial for breast cancer progression. Sorafenib is a multi-kinase receptor inhibitor with anti-angiogenic activity. Stigmasterol is a phytosterol with anticancer activity. The aim of this study was to investigate molecular mechanisms of action of sorafenib and stigmasterol in two different human breast cancer cell lines and assess their combined impact on modulation of signaling pathways that control breast cancer pathogenesis. Methods and results: MCF-7 and MDA-MB 231 cells were used as models of human breast cancer. MTT assay was used to assess cytotoxicity. Angiogenic VEGF/ VEGFR-2/ ERK/ NF-kB signaling pathway was investigated using ELISA and RT-PCR techniques. Apoptotic markers (caspase-3, Bcl2) and a proliferation marker (Ki-67) were assessed using colorimetric and ELISA techniques. Sorafenib combined with stigmasterol increased caspase-3 activity and decreased Bcl2, VEGF-A, VEGFR-2, NF-kB and Ki-67 levels. Conclusion: The combination of Sorafenib and stigmasterol may be a useful therapeutic regimen for breast cancer treatment. This combination may inhibit angiogenesis and promote apoptosis signaling.
Untangling the changing impact of non-pharmaceutical interventions and vaccination on European Covid-19 trajectories
Authors: Ge Yong , Zhang Wenbin , Wu Xilin , Ruktanonchai Corrine , Liu Haiyan , Wang Jianghao , Song Yongze , Liu Mengxiao , Yan Wei , Cleary Eimear , Qader Sarchil , Atuhaire Fatumah , Ruktanonchai Nick , Tatem Andrew , Lai Shengjie 
Published: November 2021

Abstract
Non-pharmaceutical interventions (NPIs) and vaccination are two fundamental approaches to mitigate the coronavirus disease 2019 (Covid-19) pandemic. Vaccination strategies are generally less costly and socially/economically disruptive than NPI strategies, such as business closures, social distancing, and face mask mandates, as evidenced by highly vaccinated countries generally rolling back NPIs. However, the respective real-world impact of an NPI strategy versus vaccination strategy, or the combination of both, on mitigating Covid-19 transmission remains uncertain. To address this, we built a Bayesian inference model to explore the changing effectiveness of NPIs and vaccination based on the assembled large-scale dataset, including epidemiological parameters, variants, vaccines, and control variable. Here we show that NPIs were still considerably complementary or even synergistic to vaccination in the effort to curb the Covid-19 infection before reaching herd immunity. We found that (1) the synergistic effect of NPIs and vaccination was 46.9% (reduction in reproduction number) in September 2021, whereas the effects of NPIs and vaccination alone were 20.7% and 28.8%, respectively; (2) effectiveness of NPIs is less sensitive to emerging COVID-19 variants but decreases with vaccination progress, as NPIs may unnecessarily restrict the vaccinated population. The effectiveness of NPIs alone declined approximately 23% since the introduction of vaccination strategies, where the relaxation of NPIs promoted the decline from May 2021. Our results demonstrate that the decision to relax NPIs should consider the real-world vaccination rate of the relevant population, which is determined by the observed vaccine efficacy in relation to extant and emerging variants.
Low prevalence of Plasmodium falciparum parasites lacking pfhrp2/3 genes among asymptomatic and symptomatic school-age children in Kinshasa, Democratic Republic of Congo
Authors: Nundu Sabin , Arima Hiroaki , Simpson Shirley , Chitama Ben-Yeddy Abel , Munyeku Yannick Bazitama , Muyembe Jean-Jaques , Mita Toshihiro , Ahuka Stve , Culleton Richard , Yamamoto Taro 
Published: November 2021

Abstract
Background. Loss of efficacy of malaria diagnostic tests may lead to untreated or mistreated cases, compromising case management and control. There is an increasing reliance on rapid diagnostic tests (RDTs), with the most widely used of these targeting the Plasmodium falciparum histidine-rich protein 2 gene. There are numerous reports of the deletion of this gene in P. falciparum parasites in some populations, rendering them undetectable by PfHRP2 RDTs. We aimed to identify P. falciparum parasites lacking the P. falciparum histidine rich protein 2 and 3 genes isolated from asymptomatic and symptomatic school-age children in Kinshasa, Democratic Republic of Congo. Methods. We assessed the performance of PfHRP2-based RDTs in comparison to microscopy and PCR. PCR was then used to identify parasite isolates lacking pfhrp2/3 genes. Results. Of 462 DNA samples analysed, deletions of the pfhrp2 and pfhrp3 genes were found in only three (2%) samples and one (1%) sample in the RDT positive subgroup, respectively. No parasites lacking the pfhrp2/3 genes were found in the RDT negative subgroup. Conclusion. Plasmodium falciparum histidine-rich protein 2/3 gene deletions are uncommon in the surveyed population, and do not result in diagnostic failure. We encourage the use of rigorous PCR methods to identify pfhrp2/3 gene deletions in order to minimize the overestimation of their prevalence.
A qualitative study on Patient-Centered Care and Perception of Nurses in Primary Healthcare Practice
Authors: Lateef Adepeju , Mhlongo Euphemia Mbali 
Published: November 2021

Abstract
Background: Patient-centered care (PCC) approach has continued to gain recognition globally as the key to providing quality healthcare. However, this concept is not fully integrated into the management of primary health care (PHC) in existing nursing practice due to numerous challenges. Among these challenges is the perception of nursing on PCC in the Primary Health Care system. This study seeks to present the results of qualitative research performed at various selected PHC centres on nurses’ perceptions in PCC practice. This study aim was to explore the perception of nurses on PCC. A qualitative action research approach was adopted. Methods: This study involved 30 local government PHC centres located in Osun State Southwest of the federal republic of Nigeria. Data was collected through a semi-structured interview. Thereafter, data analysis was performed using thematic analysis and NVivo 12 software to generate themes, subthemes, and codes. Results: PCC perceptions of nurses that was revealed in our findings were categorised into positive and negative themes. The negative themes include: Poor approach by the nurses and lack of enforcement agency. The positive themes that emerged include: outcome driven healthcare, valued care provider, communication to sharpen care and driven healthcare service. Conclusion: There is need for continuous training, and upgrading of nurses in line with global recommended standards of providing quality healthcare service delivery to the people. Therefore, the federal and state governments and local government council through the Nursing Council body should regulate, supervise, monitor and enforce the use and implementation of PCC in the PHC healthcare system.