bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Conventional and Non-conventional Organic Sources of Plant Nutrients and Industrial Refuse for Yield and Quality Enhancement of Radish
Authors: Venkatakrishnan D. , Arulkumar V. , Kamalakannan P. , Sathyaseelan V. 
Published: May 2021

Background: India generates about 50 million tons of municipal solid wastes (MSW) every year. Composting MSW is viewed as a low-cost method of diverting organic wastes from landfills in to a valuable product of agricultural importance. Farm Yard Manure (FYM) is an organic matter rich with a small quantity of nitrogen, while rice hull ash is a good source of plant nutrients particularly of potash. Bagasse ash is a waste obtained from sugar industries and is capable of supplying significant amount of plant nutrients. The present investigation aimed to study the effect of organic sources of plant nutrients and industrial waste on yield and quality of radish as a supplementary source of plant nutrients. Methods: A pot trial investigation was carried out during 2019 at Annamalai University, Chidambaram, Tami Nadu to study the influence of conventional and non-conventional organic sources of plant nutrients and industrial refuse on yield and quality of radish. Under this trial, FYM (12.5 t ha-1), Municipal Solid Waste Compost (25 t ha-1), Rice hull ash (5 t ha-1), Bagasse ash (10 t ha-1) with 100% RDF and 75% RDF were tried. Result: The present investigation under pot trial showed that the maximum radish root yield, shoot yield and quality were observed due to the application of organic sources of plant nutrients of both conventional and non-conventional organic sources and industrial refuse.
Alterations in Biochemical Markers of Liver and Kidney Function and Oxidative Stress Indices on Sub-acute Exposure of Enrofloxacin in Albino Rats
Authors: Mishra Prateek , Gautam Vidhi , Sharma R.K. , Tiwari Anushri 
Published: May 2021

Background: The present study was performed to evaluate Alterations in biochemical markers of liver and kidney function and oxidative stress indices on sub-acute exposure of enrofloxacin in albino rats. Methods: Albino rat weighing 200-300 gm were treated with enrofloxacin orally with the help of gavage needle and devided into three groups each group consist six rats. The rats of group I were served as control. However, rats of group II and III were treated with enrofloxacin @ 5 mg/kg b.wt., enrofloxacin @ 10 mg/kg b.wt. respectively. All the groups received medication orally, once daily for 28 days and blood samples were collected on the 28 day of experiment by the help of capillary tube and processed by laboratory methods. Result: Enrofloxacin altered the functions of liver and kidney as indicated by the alteration in the biochemical markers of liver and kidney function. Enrofloxacin significantly enhanced the concentration of biochemical markers of liver function viz. ALT, AST, GGT, ALP, albumin and bilirubin as compared to control. The concentration of biochemical markers of kidney function viz. BUN and creatinine was significantly enhanced after enrofloxacin administration as compared to control. Enrofloxacin administration induced oxidative stress in rats as indicated by significant decrease in concentration of catalase, superoxide dismutase and reduced glutathione in blood as compared to control. However, lipid peroxidation was significantly enhanced as indicated by increased level of MDA in blood as compared to controlConclusion: Thus, enrofloxacin have ability to altered the biochemical markers of liver and kidney and also have potency to induced oxidative stress in albino rats after the sub-acute exposure for 28 days.
From Individual Wellbeing to Collective Welfare
Authors: Walther Cornelia C 
Published: May 2021

This article gives an overview of the twice four-dimensional logic that underpins the POZE paradigm at the individual and collective level. It is based on the understanding that human existence is a composition of four dimensions—soul, heart, mind and body, expressed as aspirations, emotions, thoughts and sensations. This individual multidimensionality reflects the collective arena, which is composed of micro, meso, macro and meta dimensions, in the form of individuals, communities, countries and planet earth.
Individual wellbeing is the cause and consequence of collective welfare, due to four principles that influence the individual and the collective sphere: change, connection, continuity and complementarity. One without the other is not sustainable. Aid must be designed and delivered with the ambition of holistic support that considers not only each dimension but contributes to the optimisation of their mutual interplay, the ultimate ambition being to lift individuals everywhere to fulfill their potential.
Inhibiting the Redox Function of APE1 Suppresses Cervical Cancer Metastasis via Disengagement of ZEB1 from E-cadherin in EMT
Authors: li qing , Zhou Zhi-Wei , Duan Wei , Qian Cheng-Yuan , Wang Shu-Nan , Deng Meng-Sheng , Zi Dan , Wang Jian-Min , Mao Cheng-Yi , Song Guanbin , Wang Dong , Westover Kenneth D. , Xu Cheng-Xiong 
Published: May 2021

Abstract
Background: Metastasis is a major challenge in cervical cancer treatment. Previous studies have shown that the dual functional protein apurinic/apyrimidinic endonuclease 1 (APE1) promotes tumor metastasis and is overexpressed in cervical cancer. However, the biological role and mechanism of APE1 in cervical cancer metastasis have rarely been studied.Methods: We used gene set enrichment analysis (GSEA) to determine the APE1-related signaling pathways in cervical cancer. To investigate the role and mechanism of APE1 in cervical cancer metastasis, invasion, immunohistochemistry, immunofluorescence, western blotting, secondary structure prediction, coimmunoprecipitation, luciferase reporter, and electrophoretic mobility shift assays were performed. The inhibitory effects of the APE1 redox function inhibitor APX3330 on cervical cancer metastasis were evaluated using animal models.Results: Clinical data showed that high expression of APE1 was associated with lymph node metastasis in cervical cancer patients. GSEA results showed that APE1 was associated with epithelial to mesenchymal transition (EMT) in cervical cancer. Ectopic expression of APE1 promoted EMT and invasion of cervical cancer cells, whereas inhibition of APE1 suppressed EMT and invasion of cervical cancer cells in a redox function-dependent manner. Notably, APE1 redox function inhibitor APX3330 treatment dramatically suppressed cervical cancer cell lymph node and distant metastasis in vivo. Furthermore, we found that APE1 enhanced the interaction between ZEB1 and the E-cadherin promoter by binding to ZEB1, thereby suppressing the expression of E-cadherin, a negative regulator of EMT.Conclusion: Our findings help to elucidate the role played by APE1 in cervical cancer metastasis and targeting APE1 redox function may be a novel strategy for inhibiting cervical cancer metastasis.
Gridded distribution of total suspended particulate matter (TSP) and their chemical characterization over Delhi during winter
Authors: Jangirh Ritu , Ahlawat Sakshi , Arya Rahul , Mondal Arnab , Yadav Lokesh , Kotnala Garima , Yadav Pooja , Choudhary Nikki , Rani Martina , Banoo Rubiya , Rai Akanksha , Saharan Ummed Singh , Rastogi Neeraj , Patel Anil , Shivani Shivani , Gadi Ranu , Saxena Priyanka , Vijayan Narayanasamy , Sharma Chhemendra , Sharma Sudhir Kumar , Mandal Tuhin Kumar 
Published: May 2021

Abstract
In the present study, total suspended particulate matter (TSP) samples were collected at 47 different sites (47 grids of 5 × 5 km2 area) of Delhi during winter (January-February 2019) in campaign mode. To understand the spatial variation of sources, TSP samples were analyzed for chemical compositions including carbonaceous species [organic carbon (OC), elemental carbon (EC) and water-soluble organic carbon (WSOC)], water-soluble total nitrogen (WSTN), water-soluble inorganic nitrogen (WSIN), polycyclic aromatic hydrocarbons (16 PAHs), water-soluble inorganic species (WSIS) (F−, Cl−, SO42−, NO2−, NO3−, PO43−, NH4+, Ca2+, Mg2+, Na+, and K+), and major & minor trace elements (B, Na, Mg, Al, P, S, Cl, K, Ca, Ti, Fe, Zn, Cr, Mn, Cu, As, Pd, F, and Ag). During the campaign, the maximum concentration of several components of TSP (996 µg/m3) was recorded at the Rana Pratap Bagh area representing a pollution hotspot of Delhi. The maximum concentrations of PAHs were recorded at Udhyog Nagar, a region close to heavily loaded diesel vehicles, small rubber factories, and waste burning areas. Higher content of Cl− and Cl−/Na+ ratio (> 1.7) suggests the presence of nonmarine anthropogenic sources of Cl− over Delhi. Minimum concentrations of OC, EC, WSOC, PAHs, and WSIS in TSP were observed at Kalkaji representing the least polluted area in Delhi. Enrichment factor < 5.0 at several locations and a significant correlation of Al with Mg, Fe, Ti, and Ca and C/N ratio indicated the abundance of mineral/crustal dust in TSP over Delhi. Principal component analysis (PCA) was also performed for the source apportionment of TSP and extracted soil dust was found to be the major contributor to TSP followed by biomass burning, open waste burning, secondary aerosol, and vehicular emissions.
Reconstructing atmospheric circulation and sea-ice extent in the West Antarctic over the past 200 years using data assimilation
Authors: Dalaiden Quentin , Goosse Hugues , Rezsohazy Jeanne , Thomas Elizabeth R. 
Published: May 2021

Abstract
The West Antarctic climate has witnessed large changes during the second half of the 20th century including a strong and widespread continental warming, important regional changes in sea-ice extent and snow accumulation, as well as a major mass loss from the melting of some ice shelves. However, the potential links between those observed changes are still unclear and instrumental data do not allow determination of whether they are part of a long-term evolution or specific to the recent decades. In this study, we analyze the climate variability of the past two centuries in the West Antarctic sector by reconstructing the key atmospheric variables (atmospheric circulation, near-surface air temperature and snow accumulation) as well as the sea-ice extent at the annual timescale using a data assimilation approach. To this end, information from Antarctic ice core records (snow accumulation and δ 18 O and tree-ring width records situated in the mid-latitudes of the Southern Hemisphere are combined with the physics of climate models using a data assimilation method. This ultimately provides a complete spatial reconstruction over the west Antarctic region. Our reconstruction reproduces well the main characteristics of the observed changes over the instrumental period. We show that the observed sea-ice reduction in the Bellingshausen-Amundsen Sea sector over the satellite era is part of a long-term trend, starting at around 1850 CE, while the sea-ice expansion in the Ross Sea sector has only started around 1950 CE. Furthermore, according to our reconstruction, the Amundsen Sea Low pressure (ASL) displays no significant linear trend in its strength or position over 1850--1950 CE but becomes stronger and shifts eastward afterwards. The year-to-year sea-ice variations in the Ross Sea sector are strongly related to the ASL variability over the past two centuries, including the recent trends. By contrast, the link between ASL and sea-ice in the Bellingshausen-Amundsen Sea sector changes with time, being stronger in recent decades than before. Our reconstruction also suggests that the continental response to the variability of the ASL may not be stationary over time, being significantly affected by modification of the mean circulation. Finally, we show that the widespread warming since 1958 CE in West Antarctica is unusual in the context of past 200 years and is explained by both the deeper ASL and the positive phase of the Southern Annular Mode.
Health-related quality of life and estimation of minimally important difference in the Functional Assessment of Cancer Therapy-Endocrine Symptom (FACT-ES) score in postmenopausal ER-positive, HER2-negative metastatic breast cancer with low sensitivity to endocrine therapy
Authors: Kikawa Yuichiro , Hagiwara Yasuhiro , Fujisawa Tomomi , Araki Kazuhiro , Iwamoto Takayuki , Sangai Takafumi , Shien Tadahiko , Takao Shintaro , Nishimura Reiki , Takahashi Masato , Toyama Tatsuya , Aihara Tomohiko , Mukai Hirofumi , Taira Naruto 
Published: May 2021

Abstract
Purpose

The HORSE-BC study previously demonstrated that 2nd-line endocrine therapy (ET) for metastatic breast cancer (MBC) patients with acquired endocrine resistance still provided a clinically meaningful benefit. Herein, we investigated health-related quality of life (HR-QOL) in HORSE-BC.

Methods

MBC patients with acquired endocrine resistance who were scheduled for 2nd-line ET were recruited. HR-QOL was assessed at baseline and 1 and 3 months after initiation of 2nd-line ET. To investigate the minimally important difference (MID) in the Functional Assessment of Cancer Therapy-Endocrine Symptoms (FACT-ES), we evaluated the means and standard deviations (SDs) for the distribution-based method, and differences in the change in HR-QOL for the anchor-based method. We also investigated the association between FACT-ES total scores and clinical benefit.

Results

Overall, 56 patients were enrolled. Of these, 47 were analyzed. When defined as 1/3 SD estimates based on the distribution method, the calculated MID was 5.9. The MIDs of the FACT-ES total scores based on the anchor method were 7.7 for decline and 4.1 for improvement. The proportions of MID decline were 6.1% and 14.7% lower in patients who experienced clinical benefits than in those who did not at 1 month and 3 months, respectively. The respective ratios of MID improvement in patients who experienced clinical benefits were 18.3% and 3.2% higher, respectively; mean change in FACT-ES total score from baseline was improved in patients who experienced clinical benefits.

Conclusion

Maintaining HR-QOL as determined by FACT-ES may be associated with clinical benefits in patients with acquired endocrine-resistant MBC treated with ET.
Binary Image Steganography based on Permutation
Authors: Sadié Juvet Karnel , Ekodeck Stéphane Gael Raymond , Ndoundam Rene 
Published: May 2021

Abstract
We propose a steganographic scheme based on permutations, which improves the capacity of embedding information in a series of p host binary images. Given a host binary image block of size m x n bits and any embedding technique T, where T can hide Q(m, n) bits of data in the image; given p images, T can hide p x Q(m, n) bits of data in these images. Our scheme improves the capacity of embedding information in p images such that, instead of p x Q(m, n) bits, it can hide p x log2(p) + p x Q(m, n)bits. The results which have been obtained by experiments, show that our model performs a better hiding process in terms of hiding capacity.
Effect of the Green Synthesized rGO and Mg/rGO Nanocomposites Using High Molecular Weight Polyphenols of Rosa Canina Fruit and Investigation of Their Effects on Phytochemical Assay and Toxicity in Organ Culture of Mentha Longifolia
Authors: Jafarirad Saeed , Kosari‑Nasab Morteza , Aminpour Monireh , Rezaei Zahra 
Published: May 2021

Abstract
Reduced graphene oxide (rGO) and Mg/rGO nanocomposites (NCs) were prepared by an eco-friendly technique using high molecular weight polyphenols of Rosa canina fruit. Physicochemical properties and cytotoxicity to Mentha longifolia in vitro cultures of these nanomaterials were examined by using XRD, FESEM, EDX, FTIR, DLS/Zeta potential, UV–Visible and GC-MS techniques. The characterization techniques confirmed the synthesis of rGO and Mg/rGO NCs with particle sizes less than 20 nm (based on FESEM). In accordance to the biological measurements, rGO showed in vitro cytotoxicity to M. longifolia shoot cultures. Mg/rGO NCs showed no significant difference in the growth parameters except for a decrease in the soot number at the concentrations of 50 and 150 mg/L and a decrease in the length of the tallest root at the concentrations of 100 and 150 mg/L, however, efficiently improved the photosynthetic pigment contents. The phytochemical assay depicted that the total content of volatile compounds was increased in the treated cultures with 25, 50, and 100 mg/L of rGO and Mg/rGO NCs in comparison to the control. Generally, the more oxygenated and hydrocarbon sesquiterpenes was observed in the cultures treated with 25 and 100 mg/L of rGO and 25 and 50 mg/L of Mg/rGO NCs.
Modeling The Effect of Nitrogen Dioxide Produced In Shazand Power Plant Upon Air Pollution In Arak, Iran Using Sentinel-5 Satellite Data
Authors: Ghannadi Mohammad Amin , Shahri Matin , Moradi Amir Reza 
Published: May 2021

Abstract
Nowadays, air pollution and its negative effects on human health is regarded as one of the most fundamental problems in the world. Iran as a developing country also deals with the issue of air pollution. Nitrogen dioxide (NO2) as one of the air pollutants leads to serious damage to the human respiratory system. The power plants are recognized as one of the main sources of producing NO2. In this research, the effect of NO2 produced in Shazand power plant on the air pollution in Arak metropolitan area, as one of the most polluted cities in Iran will be investigated using a third-order rational mathematical model. Sentinel-5 satellite images have been applied to monitor NO2 in the study area during the two years 2020-2019. The results indicate that the proposed model has been successful to model the relationship between the amount of NO2 produced in Shazand power plant and its propagation in Arak city using a set of control points with the values of RMSE, MAE and R2 equal to 6-10×2.1, 6-10×1.3 and 0.99 respectively. The results of model validation using check points with the values of RMSE, MAE and R2 equal to6-10×1.7 , 6-10×1.1 and 0.99 respectively indicate that the model can also be applied to any data location in the study area.
Leonurine Attenuates Pressure-Overload Cardiac Hypertrophy Induced By Abdominal Aortic Constriction In Rats
Authors: Xiaoli Ding , Qingqing Yuan , Haibing Qian 
Published: May 2021

Abstract
Background: Myocardial hypertrophy occurs in many cardiovascular diseases. Leonurine (Leo) is commonly used for cardiovascular and cerebrovascular diseases. However, whether it can prevent cardiac hypertrophy is not known. The aim of this study was to investigate the effect and mechanism of Leonurine (Leo) against pressure-overload cardiac hypertrophy induced by abdominal aortic constriction (AAC) in rats. Methods: To answer this question, we prove it in the following way: Cardiac function was evaluated by hemodynamic; the left ventricle enlargement was measured by heart weight index (HWI) and left ventricular mass index (LVWI); myocardial tissue changes and myocardial cell diameter (MD) were determined by Hematoxylin and eosin (HE) staining; theβ-myosin heavy chain(β-MHC)and atrial natriuretic factor (ANF), which are recognized as a marker of cardiac hypertrophy, were determined by Real-time quantitative PCR (qRT-PCR), then another gene phospholipase C (PLC), inositol triphosphate (IP3), which associated with RAS were determined by Western blot(WB). angiotensin II (Ang II), angiotensin II type 1 receptor (AT1R) were determined by ELISA, WB and qRT-PCR methods. Finally, we measured the level of Ca2+ by microplate method and the protooncogene c-fos and c-myc mRNA in left ventricular myocardium by qRT-PCR.Results: Compare with control group, Leonurine can improve systolic dysfunction; inhibit the increase of left cardiac; inhibit myocardial cells were abnormally large and restrain the changes of cardiac histopathology; decrease the expression of β-MHC, ANF, Ang II, AT1R, c-fos and c-myc mRNA and the protein levels of PLC, IP3, AngII and AT1R in left ventricular myocardium, in addition, the content of Ca2+ also decrease. Conclusion: Therefore, Leonurine can inhibit cardiac hypertrophy induced by AAC and its effects may be associated with RAS.
Pre-Implementation Assessment of Tobacco Cessation Interventions in Substance Use Disorder Residential Programs in California
Authors: Fokuo J. Konadu , McCuistian Caravella L. , Masson Carmen L. , Gruber Valerie A. , Straus Elana , Wong Jessie , Guydish Joseph 
Published: May 2021

Abstract
Background: Across the United States, substance use disorder (SUD) treatment programs vary in terms of their tobacco-related policies and cessation services offered to clients. Guided by the Consolidated Framework for Implementation Research (CFIR), the current study identified key factors that may influence the implementation of tobacco related cessation policies and services in residential SUD programs. Methods: We conducted semi-structured qualitative interviews with sixteen residential treatment program directors in California. The analysis was guided by a deductive approach using CFIR domains and constructs to develop codes and identify themes. ATLAS.ti software was used to facilitate thematic analysis of interview transcripts. Findings: Guided by the CFIR constructs, themes that arose as facilitators for implementation included the relative advantage of the intervention compared with current practice, external policies/incentives to support tobacco related policy, program directors strong commitment and high self-efficacy to incorporate cessation into SUD treatment, and recognizing the importance of planning and engaging opinion leaders. Potential barriers included the SUD reovery culture, low stakeholder enagement, organizational culture, lack of workforce expertise and, lack of reimbursement for smoking cessation services.Conclusion: The CFIR provided a valuable framework for evaluating factors that may influence implementation of tobacco policies and services in SUD treatment. In order to support successful implementation, residential SUD programs (staff and clients) require extensive education on the effectiveness of tobacco cessation efforts on health outcomes and publicly funded SUD treatment programs should receive support through expanded reimbursement for tobacco cessation services.
Mesenchymal Stem Cells Protect Against Ferroptosis via Exosome-Mediated Stabilization of Xct in Acute Liver Injury
Authors: Lin Feiyan , Chen Wenyi , Zhou Jiahang , Zhu Jiaqi , Yao Qigu , Feng Bing , Feng Xudong , Shi Xiaowei , Pan Qiaoling , Yu Jiong , Li Lanjuan , Cao Hongcui 
Published: May 2021

Abstract
Background: Ferroptosis, a newly recognized form of regulated cell death, was recently identified as a novel therapeutic target in tissue injury. Various studies have shown that administration of mesenchymal stem cells (MSC) is a promising therapeutic approach to repair liver injury. However, the role of ferroptosis in acute liver injury (ALI) and MSC-based therapy is unknown. Results: Here we found that CCl4 induced elevated lipid reactive oxygen species (lipid-ROS) and mRNA levels of putative molecular markers of ferroptosis such as Ptgs2 and LOX genes. CCl4 also downregulated the xCT protein levels resulting in the accumulation of lipid peroxidation and ferroptosis. MSC transplantation largely abolished CCl4-induced ferroptosis. Furthermore, the protective effects of MSC against ferroptosis were closely correlated with exosome-mediated stabilization of xCT. Administration of MSC-Exo restored the xCT protein level, decreased the elevated lipid-ROS level and Ptgs2 and LOX mRNA levels, and promoted liver restoration by inhibiting ferroptosis. Interestingly, in ALI mouse livers after MSC-Exo treatment, exosome-induced recovery of xCT protein was accompanied by upregulation of CD44 and OTUB1. The level of ubiquitinated xCT upregulated by CCl4 was significantly downregulated by OTUB1-mediated deubiquitination, and strong interactions of xCT with OTUB1 and CD44 proteins were detected. Conclusions: Taken together, our data indicate that MSC-Exo has a protective role against ferroptosis by maintaining xCT function. This provides a novel therapeutic strategy for ferroptosis-induced ALI.