bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inventory of landslides triggered by hurricane Matthew in Guantánamo, Cuba
Authors: Vaciano Yusmira Savón , Tellez Ricardo Delgado , Abella Enrique A. Castellanos , Lacaba Rafael Guardado , Cruz Arisleidys Peña de la 
Published: April 2021

Abstract
An inventory of landslides triggered by Hurricane Matthew (4–5 October 2016) through the eastern region of Cuba was carried out using Sentinel 2A satellite images. The inventory was compared with the slope map generated from the digital elevation model at 25 m per pixel and with the geological map at 1: 100 000 scale. The precipitation data from the 1-hour rain gauge records of four stations of the Cuban Institute of Meteorology (INSMET) and 24-hour rain gauge records of six stations of National Institute of Hydraulic Resources (INRH) were processed and analysed during this event. In total, 237 landslides were classified into rockslides, debrisflows and topples. A wide distribution of landslides was found within the selected slope classes, depending of the landslide type. Most of the landslides were generated in green schist of volcanic and vulcanoclastic rocks and rocks of the ophiolitic complex made up of ancient remains of oceanic crust. Findings increase understanding of landslide occurrence in this area in order to update landslide hazard map and to reduce landslide risk.
Boosting Influences From circ_0048856 On Non-Small Cell Lung Cancer Advancement Via Aiming At miR-1287-5p
Authors: He Yinzai , Liu Yanheng , Cha Nier , Gao Yanwei , Li Feng , Zhang Meng , Luan Wei 
Published: April 2021

Abstract
Background: Non small cell lung cancer (NSCLC) is one of the main causes of death in human diseases. In this study, we aimed to explore the prognostic value of serum circ_0048856 in patients with NSCLC and its relationship with miR-1287-5p.Methods: The expression levels of circ_0048856 and miR-1287-5p in serum of NSCLC patients and healthy people were detected by qRT-PCR. The relationships between circ_0048856 expression and clinical data were evaluated via χ2 test. Overall survival analysis was carried out via Kaplan-Meier method with log rank test. Cox regression analysis was taken to evaluate the prognostic ability of circ_0048856 in NSCLC. Luciferase reporter gene was used to detect the targeting relationship between circ_0048856 and miR-1287-5p.Results: The expression of circ_0048856 in serum of NSCLC patients was significantly higher than that of healthy volunteers (P < 0.001). And its high expression was significantly correlated with TNM stage (P = 0.002) and lymph node metastasis (P < 0.001). In addition, Kaplan Meier log rank test analysis showed that the overall survival of patients with high expression of circ_0048856 was significantly shorter than that of patients with low expression of circ_0048856 (log rank test, P = 0.002). Serum circ_0048856 expression is an independent prognostic biomarker in NSCLC patients. Furthermore, we found that miR-1287-5p is a direct downstream miRNA of circ_0048856 through luciferase reporter gene analysis, and there is a negative correlation between circ_0048856 and miR-1287-5p.Conclusion: Serum circ_0048856 is an independent prognostic biomarker in patients with NSCLC. Circ_0048856 can participate in the progression of NSCLC by targeting miR-1287-5p.
Nomogram for chemotherapy decision-making in patients with small triple-negative breast tumor: A population-based study
Authors: Chen Xin-Yu , Shao Yi-Lin , Liu Xing , Zhang Jian , Zhi Wen-Xiang , Hu Xi-Chun , Tao Zhong-Hua 
Published: April 2021

Abstract
Purpose: Small triple-negative breast cancer (TNBC) without lymph node invasion is considered less aggressive. This study aimed to develop nomograms for deciding on the appropriateness of chemotherapy for these patients.Methods: The data of patients diagnosed with T1abN0M0 TNBC between 2010 and 2016 were extracted from the Surveillance, Epidemiology, and End Results database. Clinicodemographic characteristics were integrated into nomograms for predicting overall survival (OS) and breast cancer-specific survival (BCSS). Nomogram performance was analyzed according to calibration and discrimination. The subpopulation treatment effect pattern plot (STEPP) was further applied to make individualized chemotherapeutic decisions.Results: Overall, 3133 patients with T1abN0M0 TNBC were evaluated; they were divided equally into the training and validation cohorts. Most tumors were grade III (62.6%) and ductal carcinoma of no special type (88.8%). The median follow-up time was 44.0 months, and 133 patients (4.3%) died by the end of the follow-up. Eight independent prognostic factors, namely, age, race, marital status, tumor size, histology, grade, surgery, and chemotherapy, were identified and used in nomogram construction. The calibration curves showed satisfactory agreement between prediction and observation. The C-indices of the nomograms were significantly higher than those of traditional TNM staging (OS: 0.701 vs 0.503; BCSS: 0.691 vs 0.506). The patients in the training cohort were stratified into two risk groups based on the OS nomogram score cutoff (213), and the groups showed a significant difference in survival, as was further confirmed in the validation cohort. The STEPPs of 5-year OS according to the nomogram score demonstrated distinct patterns of absolute chemotherapeutic effect, with low-risk patients achieving better survival regardless of chemotherapy. In high-risk patients, a significant and consistent chemotherapeutic benefit was observed at the average of 3.7%. Conclusion: At a cutoff score of ≥ 213, the nomogram accurately identified TNBC patients likely to receive a survival benefit from chemotherapy.
Photodynamic Therapy For Synovial Hyperplasia in Patients With Refractory Rheumatoid Arthritis : A Study Protocol For A Randomised Double-Blind Blank-Controlled Prospective Trial
Authors: Zhao Xiaofeng , CHEN Ensheng , ZUO Fangfang , BI Yanan , CAO Yanyan , YUAN Yi , LI Kaiqin , XUAN Yanan , LI Libo , WAN Lijuan , ZHANG Xiangqun , YAN Feifei , ZHOU Jiyuan , YIN Kun , XIAO Changhong 
Published: April 2021

Abstract
Background Persistent synovial hyperplasia with inflammation in rheumatoid arthritis is the main cause of refractory rheumatoid arthritis (RRA). As a means of local treatment, photodynamic therapy (PDT) confers less trauma, stronger targeting, and more durable curative effects than steroid injections or arthroscopic synovectomy. The aim of this trial will be to evaluate the short-, medium- and long-term clinical efficacy of PDT in the treatment of RRA synovial hyperplasia and synovitis. Methods and analysis This is a single-centre, randomised, double-blind, blank-controlled, prospective trial. A sample of 126 RRA patients will be randomly divided into 3 groups: the control group, the PDT once group, and the PDT twice group, 42 per group. The trial will be conducted at the Rheumatology and Immunology Department of Integrated Hospital of Traditional Chinese Medicine, Southern Medical University. Assessments at baseline, the first operation, the second operation (4th week), and then at three follow-ups (8th week, 24th week, 48th week) will be performed. The Ultrasound Compound Score of Synovitis (UCSS), knee joint clinical assessments, Disease Activity Score in 28 Joints (DAS28), serological inflammation indexes and specific antibody levels, pathological biopsies of synovial tissue and X-ray assessments of bone destruction will be evaluated. An improvement in the UCSS will be the main endpoint, and the UCSS at the 8th week versus the baseline value will reflect the short-term outcome of the operation. The results of the 24th week and 48th week follow-up will reflect the medium- and long-term curative effects, respectively. Ethics and dissemination The protocol was approved by the Medical Ethics Committee of Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, China (Approval No. of the ethics committee: NFZXYEC-2017-005) and later registered in the Chinese Clinical Trials Registry with Registration number ChiCTR1800014918 (approval date: February 21, 2018). All procedures will be in accordance with Chinese laws and regulations, as well as the WMA Declaration of Helsinki. Any modifications to the protocol will be approved by the Ethics Committee of our hospital. Trial registration number ChiCTR1800014918.
Associations between plasma protein, IgG and IgA N-glycosylation and metabolic health markers in pregnancy and gestational diabetes
Authors: Štambuk Tamara , Kifer Domagoj , Duvnjak Lea , Lovrenčić Marijana Vučić , Gornik Olga 
Published: April 2021

Abstract
Background. Monitoring of the human circulating N-glycome could provide valuable insight into an individual’s metabolic status. Therefore, we examined if aberrant carbohydrate metabolism in gestational diabetes mellitus (GDM) associates with alterations in plasma protein, immunoglobulin G (IgG) and immunoglobulin A (IgA) N-glycosylation.Methods. Plasma protein, IgG and IgA N-glycans were enzymatically released, purified and chromatographically profiled in 48 pregnant women with normal glucose tolerance and 41 pregnant women with GDM, all sampled at 24-28 weeks of gestation.Results. Fasting insulin exhibited significant associations to numerous glycan traits, including several plasma protein N-glycans bearing bisecting GlcNAc, afucosylated fully sialylated IgG glycan and fully sialylated triantennary IgA glycan (padj range: 7.66x10-05–1.15x10-02). Insulin resistance markers HOMA2-IR and HOMA2-%B were mostly associated to the same glycan structures as fasting insulin. Both markers also showed positive association with high-branched plasma glycans (padj=1.15x10-02 and 2.26x10-03) and negative association with low-branched plasma glycans (padj=1.25x10-02 and 2.27x10-03). Additionally, HOMA2-%B index was significantly related to the glycosylation features describing IgG sialylation. Multiple glycans showed significant associations with total cholesterol and triglyceride levels. None of the tested glycan traits showed a significant difference between GDM and normoglycemic pregnancies.Conclusion. Markers of glucose homeostasis and lipid metabolism in pregnancy show extensive associations to various N-glycosylation features. However, plasma protein, IgG and IgA N-glycans were not able to differentiate pregnant women with and without GDM, possibly due to numerous physiological changes accompanying pregnancy, which confound the impact of GDM on protein glycosylation.
Dopingfree Schottky Buried Metal Layer Fully Depleted Planar FET for SCE Suppression at sub-28nm Technology Nodes
Authors: Shafi Nawaz , Bhat Aasif Mohammad , Parmaar Jaydeep Singh , Porwal Ankita , Sahu Chitrakant , Periasamy C. 
Published: April 2021

Abstract
Herein we introduce and investigate a new architectural design strategy for planar single gate field effect transistors (SG-FETs) that delivers advantages from all fronts of design, fabrication and performance perspectives. The amalgamation of schottky buried metal layer (BML) and charge plasma (CP) mechanism of doping in planar single gate architecture yields a novel type of FET called as CP-BML FET. Owing to the schottky BML induced depletion region created on the bottom side of device layer reduces effective device layer thickness (T Si ) suppressing short channel effects (SCEs) including drain induced barrier lowering (DIBL) and threshold voltage roll-off. The proposed FET has been analyzed for DC and RF performance figure of merits (FOMs) and compared to counterpart state of the art technologies with reference to ITRS performance projections. The proposed FET is also investigated the performance FOMs on for criticality of physical param- eters including gate length (Lg), device layer thickness (T Si ), BML workfunction (Φ BML ). The ION and IOFF for proposed device at Lg = 20nm read at 730 µA/µm and 7x10 - 2 pA/µm respectively. RF performance anal- ysis reveal transition frequency (ft) of 390 GHz with SS ' 75mV=dec coherent with ITRS performance pro- jections. It is found that ultra scaled (7 nm) proposed device exhibits intrinsic delay Ƭof 0.6 ps which is supe- rior to ITRS projections of 1.71 ps at 28 nm technology node. The proposed device yields P dyn of 0.248 fJ/µm at Lg=7nm implicating it to be potential candidate for low power with high performance application requirements.
Determinants of Low Birth Weight Among Newborn Delivered At Public Hospital in Silte Zone, Southern Ethiopia: Case Control Study
Authors: Mohammed Mubarek Hussen , Wabe Yasin Awol , Ali Musa Mohammed 
Published: April 2021

Abstract
Background: There is high incidence of neonatal death in Ethiopia. There are various factors that contribute to neonatal death. Low birth weight (LBW) contributes for about half of infant death. Identification of modifiable determinants of LBW for potential interventions has received little attention in southern parts of Ethiopia. The aim of this study was to identify determinants of LBW among mothers delivered at hospitals in Silte Zone, Southern Ethiopia. Methods: A hospital-based unmatched case-control study was conducted in all public hospitals of Silte Zone. In the study, the number of mothers, cases and controls from each hospital was recruited using probability proportion to population size. Baby born with weight less than 2500gm were taken as a case where as a preceding three baby with birth weight of more than or equal to 2500gm was taken as control during study time in consecutive manner. Data was collected using pretested structured questionnaire, and by anthropometric measurements. Data was entered in to Epi Info 3.5.4 and exported to SPSS Version 20 software. Descriptive analysis and binary logistic regression model were used to calculate Odds ratio with 95% confidence intervals to estimate the association between the dependent and independent variables. Variables with a p-value less than 0.05 were considered as statistically significant. Result: The mean ± SD of birth weight of was 2174.47gm ±266.2for cases and 3370.48gm ±446.48for controls. After using multivariate logistic regression analysis, mothers who did not receive iron folate during pregnancy [AOR=2.84(1.15,7.03)], mothers who had anemia (hemoglobin <11mg/dl) during pregnancy [AOR=1.03(1.12, 6.24)], mothers who did not take additional meal [AOR =3.25(1.64,6.44)], mothers who did not receive nutritional counseling during the current pregnancy [AOR =6.93(4.80,11.76)], maternal under nutrition [AOR= 3.62(2.64, 6.47)], hypertensive disorder related to pregnancy [AOR= 2.76(1.34,5.71)] and inadequate Minimum Dietary Diversity Assessment(MDD-W) [AOR=6.65(2.31, 10.16)] were found as an independent and significant predictors of low birth weight. Conclusions: Maternal under nutrition, mothers not receiving iron folate during pregnancy, mother who had anemia, lack of target nutritional counseling, mothers who did not receive additional food during pregnancy, hypertensive disorder related to pregnancy and inadequate MDD-W were significant determinants of LBW. The importance of nutritional counseling with iron folate supplements, adherence during pregnancy and maternal under nutrition screening needs to be strengthened effort to reduce incidence of LBW infants.
Spiral-based chaotic chicken swarm optimization algorithm for parameters identification of photovoltaic models
Authors: Li Miao , Li Chunquan , Huang Zhengyu , Huang Jiehui , Wang Gaige , Liu Peter X. 
Published: April 2021

Abstract
Photovoltaic (PV) systems are becoming increasingly significant because they can convert solar energy into electricity. The conversion efficiency is related to the PV models’ parameters, so it is crucial to identify parameters of PV models. Recently, various heuristic methods have been proposed to identify the parameters, but they cannot provide sufficient accurate and reliable performance. To address this problem, this paper proposes a spiral-based chaos chicken swarm optimization algorithm (SCCSO) including three strategies: i) the information-sharing strategy provides the latest information of the roosters for searching global optimal solution, beneficial to improve the exploitation ability; ii) the spiral motion strategy can enable hens and chicks to move towards their corresponding targets with a spiral trajectory, improving the exploration ability; iii) a self-adaptive-based chaotic disturbance mechanism is introduced around the global optimal solution to generate a promising solution for the worst chick at each iteration, thereby improving the convergence speed of the chicken flock. Besides, SCCSO is used for identifying different PV models such as the single diode, the double diode, and PV module models. Comprehensive analysis and experimental results show that SCCSO provides better robustness and accuracy than other advanced heuristic methods.
sc-REnF: An Entropy Guided Robust Feature Selection for Single-Cell RNA-seq Data
Authors: Lall Snehalika , Ghosh Abhik , Ray Sumanta , Bandyopadhyay Sanghamitra 
Published: April 2021

Abstract
Annotation of cells in single-cell clustering requires a homogeneous grouping of cell populations. Since single cell data is susceptible to technical noise, the quality of genes selected prior to clustering is of crucial importance in the preliminary steps of downstream analysis. Therefore, interest in robust gene selection has gained considerable attention in recent years. We introduce sc-REnF, (robust entropy based feature (gene) selection method), aiming to leverage the advantages of Rényi and Tsallis> entropies in gene selection for single cell clustering. Experiments demonstrate that with tuned parameter (q), Rényi and Tsallis entropies select genes that improved the clustering results significantly, over the other competing methods. sc-REnF can capture relevancy and redundancy among the features of noisy data extremely well due to its robust objective function. Moreover, the selected features/genes can able to clusters the unknown cells with a high accuracy. Finally, sc-REnF yields good clustering performance in small sample, large feature scRNA-seq data.
Soybean Leaf Age and Plant Stage Influence Expression of Resistance to Velvetbean Caterpillar and Fall Armyworm
Authors: de Souza Bruno Henrique Sardinha , Costa Eduardo N. , Ribeiro Zulene A. , Perlatti Bruno , Cruz Mara C. P. , Forim Moacir R. , Júnior Arlindo L. Boiça , Stout Michael J. 
Published: April 2021

Abstract
Numerous species of herbivorous insects are associated with soybeans, including the specialist velvetbean caterpillar (VBC), Anticarsia gemmatalis, and the generalist fall armyworm (FAW), Spodoptera frugiperda. Expression of plant resistance is influenced by factors intrinsic to host plants, such as leaf age and plant stage, which can differentially affect specialist and generalist insects due to varying levels of plant defense and corresponding insect adaptation. In this study four experiments were carried out to test the hypotheses that levels of antibiosis-resistance to VBC and FAW in the resistant genotype PI 227687 and susceptible genotype IGRA RA 626 RR are related to leaf age and plant stage of soybean. Furthermore, the concentrations of nutrients and selected flavonoids were quantified to give insights on possible chemical mechanisms underlying the resistance. As results, development of VBC and FAW were negatively affected when larvae fed leaves of the resistant genotype, older leaves from the lower part of plants, or leaves from reproductive-stage soybeans. The effects were partly different for each insect species, and the generalist FAW was more affected by higher resistance levels in the older leaves of soybean than the specialist VBC. Distribution and concentrations of nutrients and flavonoids in soybean in function of leaf age and plant stage may explain the varying levels of antibiosis-resistance to VBC and FAW. These results can benefit developments of specific protocols for screening resistant soybean genotypes and pest management strategies focused in plant parts and growth stages that insect-resistance levels are lowest.
Abnormal Expression of EPB41L1 in Colon Adenocarcinoma and Effect on Prognosis
Authors: Liu jiaojiao , Liang Taotao , Ding Cong , Ji Zhenyu , Wang Ting , Liu Xin , Kang Qiaozhen 
Published: April 2021

Abstract
Background: Colon adenocarcinoma (COAD) is the most common pathological type of colorectal cancer (CRC) and further study of the molecular mechanism will help to improve the quality of life of patients with COAD. Erythrocyte membrane protein band 4.1 like 1(EPB41L1), a gene encoding protein 4.1N, has been reported to be closely associated with tumorigenesis and progression. However, the role of EPB41L1 in COAD is largely unknown and remains to be fully studied.Methods: In this study, we analyzed the mRNA expression of EPB41L1 in COAD through the Oncomine and GEO databases. Then, the relative expressions of EPB41L1 across the sub-groups of COAD were performed by the UALCAN data portal. Next, we investigated the prognostic value of EPB41L1 in COAD patients by using the UALCAN and HPA online databases. Further, the mutation of EPB41L1 in COAD was analyzed by c-Bioportal. The co-expression genes of EPB41L1 in COAD were displayed from the LinkedOmics database, and function enrichment analysis was analyzed by DAVID. The co-expression gene network was constructed through the STRING database, and the MCODE plug-in of which was used to build the gene modules, both of them were visualized by Cytoscape software. Finally, the pathway enrichment of the top modular genes in the co-expression gene network was analyzed by DAVID.Results: The results revealed that EPB41L1 is significantly upregulated with the development of COAD, leading to a poor prognosis. There are mutations in the EPB41L1 gene, but it has no significant effect on the prognosis of COAD. Moreover, the genes correlated with EPB41L1 in COAD, identified in the most highly connected sub-network, were enriched in the cell cycle. Conclusions: In summary, the above results suggest that EPB41L1 was significantly upregulated in the COAD tissues and the high expression level of EPB41L1 predicts a poor prognosis of COAD patients. Therefore, we suggest that EPB41L1 can be a potential candidate biomarker for the diagnosis and prognosis of COAD.
A Life-Saving Case of Cardiopulmonary Arrest with Cardiac Tamponade Caused by Erosion 6 Years After Percutaneous Atrial Septal Defect Closure: A Case Report
Authors: Kobayashi Takuma , Watanabe Taiji , Fu Haruka , Yohei Okada , Goto Tomoyuki 
Published: April 2021

Abstract
Background: Cardiac erosion after percutaneous atrial septal defect (ASD) closure is a rare complication that requires immediate life-saving emergency surgery. In this report, we present our successful life-saving strategy for cardiac arrest due to cardiac tamponade caused by erosion 6 years after the percutaneous closure of an ASD.Case presentation:. The patient was a 50-year-old man who received Amplatzer septal occlude (St. Jude Medical, St Paul, MN, USA) treatment for ostium secundum atrial septal defect (size: 29.5 × 27.0 mm) at another institution when he was 44 years old. Conclusion: The key point of this case was a bailout surgical strategy for patients who were hemodynamically unstable with risks of coagulopathy and multiple organ failure. This case suggests that cardiac surgeons need to be aware of the complications of percutaneous ASD closure and consider a bailout surgical strategy for patients at risk of multiple organ failure.