bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisa Komponen ITSM Pada E-learning Perguruan Tinggi Di Kota Palembang Menggunakan ITIL V.3
Authors: Hastini Safta , Cholil Widya 
Published: October 2021

E-learning merupakan peralihan proses pembelajaran dari tatap muka langsung di dalam kelas menjadi pembelajaran berbasis digital. Dalam bidang pendidikan, e-learning sebagai kemajuan teknologi informasi telah dimanfaatan sebagai sarana pembelajaran di perguruan tinggi karena dirasakan mampu meningkatkan kegiatan akademik khususnya perguruan tinggi agar menjadi lebih efektif dan efisien. Ketergantungan terhadap TI semakin meningkat untuk mencapai tujuan organisasi perguruan tinggi tersebut. Salah satu tujuan itu adalah menjadi perguruan tinggi bertaraf internasional dan maju dalam ilmu pengetahuan dan teknologi (IPTEK). Dimana perguruan tinggi yang telah memanfaatkan TI dengan baik akan menjadi perguruan tinggi yang lebih diminati oleh masyarakat. Hal ini disebabkan perguruan tinggi telah memanfaatkan TI dalam proses pembelajaran. Oleh karena itu, untuk mendukung penerapannya e-learning perguruan tinggi harus memadai bukan hanya dari aplikasi e-learning maupun user, akan tetapi proses layanan-layanan berbasis TI pada e-learning perlu diatur dan didukung dengan manajemen layanan TI yang baik agar penerapan e-learning bisa berjalan sesuai dengan yang diharapkan perguruan tinggi. Information Technology Service Management (ITSM) merupakan suatu metode yang sistematis dalam melakukan pengelolaan terhadap layanan TI dengan kerangka kerja IT Infrastructure Library Versi 3 (ITIL v.3) yang terdiri dari 5 proses yaitu service strategy, service design, service transition, service operation dan continual service improvement. ITIL v.3 melakukan perbaikan kualitas layanan TI dan pengukuran secara berkelanjutan terhadap perkembangan layanan TI yang disampaikan kepada pengguna maupun pelanggan, sehingga perguruan tinggi bisa menilai sejauhmana pengelolaan terhadap layanan TI pada e-learning sebagai sarana pembelajaran. Perguruan tinggi yang diteliti adalah perguruan tinggi swasta yang ada di kota Palembang, yaitu Universitas X, Universitas Y dan Universitas Z. Metodologi pengumpulan data menggunakan kuisioner. Selanjutnya data yang didapat dari hasil kuesioner di analisa untuk mengetahui kondisi sistem yang sedang berjalan. Berdasarkan hasil rata-rata penilaian terhadap proses ITIL v.3 nilai maturity level masing-masing perguruan tinggi yang diteliti menghasilkan nilai maturity level 3 (defined). Defined artinya proses-proses yang direncanakan dan sudah dilaksanakan secara rutin dan didokumentasikan dengan standar tertentu.
Noble Metal-Free Hierarchical ZrY Zeolite Efficient for Hydrogenation of Biomass-Derived Levulinic Acid
Authors: Hu Di , Xu Hong , Wu Zuotong , Zhang Man , Zhao Zhiyue , Wang Yuchen , Yan Kai 
Published: October 2021

Developing a low-cost and robust catalyst for efficient transformation of biomass-derived platform chemicals plays a crucial role in the synthesis of future transportation fuels. Herein, a post-synthetic strategy was employed to develop a noble metal-free and robust ZrY zeolite catalyst, which is efficient for the hydrogenation of biomass-derived levulinic acid (LA) into biofuel γ-valerolactone (GVL), whereas over 95% yield of GVL was achieved in 10 h at 220°C. The effects of acidic properties from ZrY catalysts and various reaction parameters on the catalytic performance were then discussed in detail. Subsequently, different characterization tools were used to compare the difference and relationship of structure activity between the fresh and spent ZrY catalysts. It was found that acidity and the metal–support interaction were important for the direct synthesis of GVL. This work provides a guideline to design a noble metal-free catalyst for high-value utilization of biomass-derived sources.
Association Between Waist Circumference and the Prevalence of (Pre) Hypertension Among 27,894 US Adults
Authors: Sun Jin-Yu , Hua Yang , Zou Hua-Yi-Yang , Qu Qiang , Yuan Yue , Sun Guo-Zhen , Sun Wei , Kong Xiang-Qing 
Published: October 2021

Aims: This study aimed to investigate the association between waist circumference and the prevalence of (pre) hypertension.Methods: Cross-sectional data from the 2007–2018 National Health and Nutrition Examination Survey were analyzed. The historical trend of abdominal obesity was assessed by the Cochran–Armitage trend test. After preprocessed by the multiple imputation strategy, we used generalized additive models to assess the association of waist circumference with systolic/diastolic blood pressure and performed correlation analysis by the Spearman correlation coefficient. Moreover, we used multivariable logistic regression (non-adjusted, minimally adjusted, and fully adjusted models), restricted cubic spline, and sensitivity analysis to investigate the association between waist circumference and (pre) hypertension.Results: A total of 27,894 participants were included in this study. In the fully adjusted model, waist circumference was positively associated with (pre) hypertension with odds ratios (95% confidence intervals) of 1.28 (1.18–1.40) in the young group and 1.23 (1.15–1.33) in the old group. Restricted cubic spline showed a higher prevalence of (pre) hypertension with the increase of waist circumference. In the subgroup analysis, waist circumference showed a robust trend across all BMI categories with odds ratios (95% confidence intervals) of 3.33 (1.29–8.85), 1.35 (1.17–1.57), 1.27 (1.13–1.41), and 1.09 (1.01–1.17) in underweight, normal weight, overweight, and obese individuals, respectively.Conclusion: This study highlighted waist circumference as a significant biomarker to evaluate the risk of (pre) hypertension. Our results supported the measure of waist circumference regardless of BMI when evaluating the cardiometabolic risk related to fat distribution.
Adropin and Irisin Deficiencies Are Associated With Presence of Diagonal Earlobe Crease in CAD Patients
Authors: Wei Na , Zhang Ronghuai , Zhu Zhanfang , Li Rui , Yu Qi , Wang Qingyu , Xu Cuixiang , Ma Meijuan , Mu Shengzhi , Liu Fuqiang , Wang Junkui 
Published: October 2021

Background and Aims: Diagonal earlobe crease (ELC) has been considered a potential cutaneous marker of atherosclerosis. However, the potential mechanism by which ELC and atherosclerosis are linked has not been adequately defined. Roles of adropin and irisin, novel biomarkers of endothelial function, in ELC have not been well-studied. This study aimed to test whether individuals with ELC are deficient in adropin and irisin, a characteristic that would likely promote endothelial dysfunction and provide a plausible common pathological basis for atherosclerosis and ELC.Methods: Patients diagnosed with coronary artery disease (CAD) with (n = 45) and without (n = 45) ELC were consecutively enrolled in the study. The ages of the patients enrolled ranged from 40–70 years. Other patients (n = 45) without ELC or CAD were recruited as the control group. All patients underwent coronary angiography. Serum adropin and irisin concentrations were assessed via enzyme-linked immunosorbent assay.Results: Circulating levels of irisin in the ELC group were significantly lower than those in the non-ELC group, and were highest in the control group. Serum adropin levels of the ELC group were significantly lower than those of the non-ELC group (P &lt; 0.001). Interestingly, although the serum adropin level of the control group was greater than that of the non-ELC group, the difference failed to achieve statistical significance. In subgroup analysis of CAD and ELC, both serum adropin and irisin levels of the CAD and ELC groups were lower than those of the control group (P &lt; 0.001). Receiver-operating characteristic curve analysis revealed that adropin and irisin have similar prognostic power for CAD and ELC.Conclusions: Low adropin and irisin were significantly associated with CAD and ELC. The deficiencies in adropin and irisin may be a common cause of both atherosclerosis and ELC, which explains why patients with ELC are prone to CAD.
Fibroblast Growth Factor 21 Protects Against Atrial Remodeling via Reducing Oxidative Stress
Authors: Chen Miao , Zhong Jiawei , Wang Zhen , Xu Hongfei , Chen Heng , Sun Xingang , Lu Yunlong , Chen Lu , Xie Xudong , Zheng Liangrong 
Published: October 2021

Aim: The structural and electrical changes in the atrium, also known as atrial remodeling, are the main characteristics of atrial fibrillation (AF). Fibroblast growth factor 21 (Fgf21) is an important endocrine factor, which has been shown to play an important role in cardiovascular diseases. However, the effects of Fgf21 on atrial remodeling have not been addressed yet. The purpose of the present study is to evaluate the effects of Fgf21 on atrial remodeling.Methods and Results: Adult mice were treated with Ang II, and randomly administrated with or without Fgf21 for 2 weeks. The susceptibility to AF was assessed by electrical stimulation and optical mapping techniques. Here, we found that Fgf21 administration attenuated the inducibility of atrial fibrillation/atrial tachycardia (AF/AT), improved epicardial conduction velocity in the mice atria. Mechanistically, Fgf21 protected against atrial fibrosis and reduced oxidative stress of the atria. Consistently, in vitro study also demonstrated that Fgf21 blocked the upregulation of collagen by Tgf-β in fibroblasts and attenuated tachypacing-induced oxidative stress including reactive oxygen species (ROS), Tgf-β, and ox-CaMKII in atrial myocytes. We further found that Fgf21 attenuated oxidative stress by inducing antioxidant genes, such as SOD2 and UCP3. Fgf21 also improved tachypacing-induced myofibril degradation, downregulation of L-type calcium channel, and upregulation of p-RyR2, which implicated protective effects of Fgf21 on structural and electrical remodeling in the atria. Moreover, Nrf2 was identified as a downstream of Fgf21 and partly mediated Fgf21-induced antioxidant gene expression in atrial myocytes.Conclusion: Fgf21 administration effectively suppressed atrial remodeling by reducing oxidative stress, which provides a novel therapeutic insight for AF.
Development and Validation of Risk Prediction Model for New-Onset Diabetes After Percutaneous Coronary Intervention (NODAP): A Study Protocol for a Retrospective, Multicenter Analysis
Authors: Li Yiwen , Cui Jing , Liu Yanfei , Chen Keji , Huang Luqi , Liu Yue 
Published: October 2021

Background: Type 2 Diabetes mellitus (T2DM) is a major risk factor for cardiovascular diseases and increase mortality. Clinical outcomes of patients after percutaneous coronary intervention (PCI) were worse in T2DM patients than those without T2DM. New-onset diabetes after PCI (NODAP) is often observed during long-term follow-up and this further aggravates cardiovascular diseases. Several studies had focused on patients after PCI with known T2DM. Previous studies showed that impaired glucose tolerance and aging are risk factors that promote NODAP. Considering the unique characteristics of patients after PCI, we will further study relevant risk factors. We sought to investigate the potential predictors of acute coronary syndrome patients with NODAP by a multicenter retrospective cohort study.Methods: This is a multicenter retrospective cohort study including patients after PCI. Clinical medical records of these patients were collected from four hospitals in different areas in China, from 2010 to 2021. Patients' demographic information, medical history, diagnostic testing, PCI-related information, medication situation will be summarized using descriptive statistics, and correlation analysis was performed on the development of new-onset diabetes. Variation will be described and evaluated using χ2 test or Kreskas-Wallis test. The prediction model will be verified by a validation set.Discussion: A novel diabetes prediction model for patients after PCI is established, and this study can achieve advanced intervention for the occurrence of NODAP. Owing to its retrospective nature, this study has some limitations, but it will be further studied through supplement data collection or prospective study. The study has been registered for clinical trials by the Chinese Clinical Trial Registry (ChiCTR2100047241).
Meta-Analysis Approach to Measure the Effect of Integrated Nutrient Management on Crop Performance, Microbial Activity, and Carbon Stocks in Indian Soils
Authors: Padbhushan Rajeev , Sharma Sheetal , Kumar Upendra , Rana D.S. , Kohli Anshuman , Kaviraj Megha , Parmar Brajendra , Kumar Rajkishore , Annapurna K. , Sinha Abhas Kumar , Gupta Vadakattu V.S.R. 
Published: October 2021

Cereal crop production gains under conventional agricultural systems in India have been declining in recent years because of inadequate management practices, creating a considerable concern. These activities were shown to deplete soil organic matter stocks, resulting in a decrease in microbial activity and soil organic carbon (SOC) content. Moreover, even with minimal use of organic sources in cultivated land, soil carbon status deteriorated, particularly in subtropical climates. Integrated nutrient management (INM), a modified farming method, has the potential to effectively utilize organic and inorganic resources, to improve the quality of soils and crops, and making farming more economically viable and sustainable. The aim of this study was to use meta-analysis to quantify the effects of INM on crop production, soil carbon, and microbial activity in Indian soils. During the years 1989–2018, data from various research studies in India, mainly on nutrient management in rice and wheat crops, were collected. Meta-Win 2.1 software was used to analyze the results, and significance was determined atp&lt; 0.05. The results showed that the yield of rice and wheat was 1.4 and 4.9% more in INM than that in 100% NPK (N: nitrogen, P: phosphorous, and K: potassium), and that respective yields were comparatively higher in loamy soils (2.8%) and clayey soils (1.0%). The INM treatment increased SOC and microbial biomass carbon (MBC), resulting in improved overall soil quality. The SOC stock was increased by 23.8% in rice, 15.1% in wheat, 25.3% in loamy soils, and 14.4% in clayey soils in INM over 100% NPK. Microbial quotient (MQ) data showed significant trends between different management systems in both soil types, for example, INM &gt; 100% NPK &gt; No NPK. Due to more soil cracking and reduced aggregate stability in the rice field (greater short-term soil structural changes), the SOC stock loss in rice was higher than that in wheat. The CO2equivalent emissions were 7.9 Mg ha−1higher in no NPK (control) than in 100% NPK, and 16.4 Mg ha−1higher in control than in INM. In other words, INM increased soil carbon sequestration by 2.3 Mg ha−1as compared to using 100% NPK. Overall, the findings of this study show that INM could be a viable farming system mode in India for improving crop production, increasing soil carbon sequestration, and improving microbial activity while remaining economically and environmentally sustainable.
Drug Susceptibility and Molecular Epidemiology of Klebsiella pneumoniae Bloodstream Infection in ICU Patients in Shanghai, China
Authors: Xiao Shuzhen , Chen Tianchi , Wang Hairu , Zeng Qian , Chen Qing , Yang Zhitao , Han Lizhong , Chen Erzhen 
Published: October 2021

Background: Bloodstream infections (BSIs) are recognized as important nosocomial infections. Klebsiella pneumoniae is one of the major causes of bacteremia. This retrospective study focused on drug susceptibility and molecular epidemiology of K. pneumoniae isolated from intensive care unit (ICU) patients with BSI in Shanghai, China.Methods: Consecutive K. pneumoniae isolates were collected from ICU patients. Antibiotic susceptibility testing was conducted by the broth microdilution method. PCR was performed to detect antimicrobial resistance genes. We also completed multilocus sequence typing (MLST) and GoeBURST was used to analyze the result of MLST.Results: A total of 78 K. pneumoniae isolates were enrolled. K. pneumoniae from ICU-BSIs were highly resistant to almost all common antibiotics. The most frequent resistance determinants responsible for extended-spectrum β-lactamase (ESBL) producers were blaCTX−M−14, blaCTX−M−15, and blaCTX−M−55. KPC was the only enzyme, which was detected by the carbapenemase producers. The most principal sequence types (STs) were ST11, ST15, and ST23.Conclusion: This study presents for the first time the antibiotic resistance phenotype and molecular epidemiology of K. pneumoniae isolated from ICU patients with BSIs in Shanghai. ICU-BSI K. pneumoniae is characteristic of a high resistance rate. The occurrence of the KPC-2 enzyme may result from nosocomial clonal dissemination of ST11 K. pneumoniae.
Lack of Evidence of COVID-19 Being a Risk Factor of Alopecia Areata: Results of a National Cohort Study in South Korea
Authors: Kim Jeehyun , Hong Kwan , Gómez Gómez Raquel Elizabeth , Kim Soojin , Chun Byung Chul 
Published: October 2021

Background: Concerns about alopecia areata (AA) in coronavirus disease 2019 (COVID-19) patients have emerged among dermatologists. However, most of the extant kinds of literature have limited implications by relying on cross-sectional studies with restricted study subjects without the control group.Objective: Our study aims to investigate the risk of developing AA among COVID-19 patients in South Korea using national representative data.Methods: We used the National Health Insurance Service COVID-19 cohort database, comprising COVID-19 patients and the control group, all of whom were diagnosed from January 1, 2020, to June 4, 2020. Patients were defined as individuals who were confirmed as COVID-19 positive, regardless of disease severity. Controls were defined as those who were confirmed as COVID-19 negatives. People with a history of AA during the period 2015–2019 were excluded. The primary endpoint was a new diagnosis of AA (ICD-10-Code: L63). The adjusted incidence rate ratio (IRR) of developing AA was estimated using a log-link Poisson regression model based on incidence density. The model adjusted for (1) age and sex and (2) demographic variables (age, sex, place of residence, and income level).Results: A total of 226,737 individuals (7,958 [3.5%] cases and 218,779 [96.5%] controls) were included in the final analysis. The ratio of newly diagnosed AA was 18/7,958 (0.2%) in cases and 195/218,779 (0.1%) in controls. IRRs of COVID-19 patients having newly diagnosed AA compared to controls were 0.78 (95% CI: 0.48–1.27) when age and sex were adjusted for and 0.60 (95% CI: 0.35–1.03) when all demographic variables were adjusted for.Conclusion: Diagnosis of COVID-19 was not significantly associated with the development of AA even after appropriately adjusting for covariates.
Prognostic Value of N6-Methyladenosine-Related lncRNAs in Early-Stage Colorectal Cancer: Association With Immune Cell Infiltration and Chemotherapeutic Drug Sensitivity
Authors: Xiong Zhizhong , Li Xianzhe , Yin Shi , Xie Minghao , Mao Chaobin , Zhang Fengxiang , Chen Huaxian , Jin Longyang , Lian Lei 
Published: October 2021

Purpose: Accumulating evidence indicates that N6-methyladenosine-related long non-coding RNAs (m6A-related lncRNAs) play a crucial role in the occurrence and development of several cancers. We aimed to explore the potential role of m6A-related lncRNA signatures in predicting prognosis for early-stage (stages I and II) colorectal cancer (CRC).Methods: m6A-related lncRNA data were obtained from The Cancer Genome Atlas. Univariate Cox regression analysis was used to screen for prognostic m6A-related lncRNAs. Immune characteristics were analyzed in different subgroups created via unsupervised clustering analysis. Next, patients were randomly divided into training and test cohorts. In the training cohort, least absolute shrinkage and selection operator (LASSO) regression was performed to establish a prognostic model. The predictive value of the signature was evaluated in the training and test cohorts. Drug sensitivity was also examined.Results: A total of 1,478 m6A-related lncRNAs were identified. Two subgroups were created based on the expression of seven prognostic m6A-related lncRNAs. Prognosis was worse for cluster 1 than for cluster 2, and cluster 1 was characterized by increased numbers of M2 macrophages, decreased numbers of memory B cells, and higher expression of checkpoint genes when compared with cluster 2. Five m6A-related lncRNAs were selected to establish a risk prediction signature via LASSO regression. The 3 years overall survival (OS) was higher in the low-risk group than in the high-risk group. The area under the curve at 1, 2, and 3 years was 0.929, 0.954, and 0.841 in the training cohort and 0.664, 0.760, and 0.754 in the test cohort, respectively. Multivariate Cox regression analysis suggests that the risk score was an independent predictor of OS in both the training and test cohorts. A prognostic nomogram based on the five m6A-related lncRNAs and their clinical features was built and verified. The high-risk group was more sensitive to chemotherapeutic drugs (camptothecin and cisplatin) than the low-risk group.Conclusion: We identified two molecular subgroups of early-stage CRC with unique immune features based on seven prognostic m6A-related lncRNAs. Subsequent analyses demonstrated the usefulness of a five m6A-related lncRNA signature as a potential indicator of prognosis in patients with early-stage CRC.
Jidong Restless Legs Syndrome Cohort Study: Objectives, Design, and Baseline Screening
Authors: Wang Shu-Hong , Chen Xue-Yu , Wang Xiao-Ping 
Published: October 2021

Background: Restless legs syndrome (RLS) is a common neurological disorder with unpleasant leg sensations and serious negative effects on mental and physical health. Many observational studies showed that people with RLS had a high risk of vascular diseases, including cerebrovascular and cardiovascular diseases (CVD), but the findings were conflicting. The Jidong RLS Cohort Study is a prospective cohort study designed to mainly examine whether or not RLS is associated with an increased risk of CVD.Methods and Design: The study recruited 8,867 healthy participants older than 18 years from October 2014 to December 2015. Participants received a physical examination in the Staff Hospital, Jidong Oilfield Branch, China National Petroleum Corporation. Baseline data and blood samples were collected. Restless legs syndrome was assessed using the international RLS diagnostic criteria. All of subjects would be followed up until December 2025. Major cardiovascular/cerebrovascular events including cardiac death, myocardial infarction, ischemic heart disease, heart failure, atrial fibrillation, ischemic, and hemorrhagic stroke will be the primary outcomes. Secondary outcomes include all-cause mortality, the decline in quality of life, cognitive impairment, and depression.Discussion: This study will contribute to the scientific evidence on the association between RLS and cardiovascular risks and also provide an unprecedented opportunity for early detection and prevention of CVD.