bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efek Ekstrak Daun Seledri (Apium graveolens L.) Terhadap Struktur Histologi Ginjal Tikus (Rattus norvegi
Authors: Husna Nana Zaimatul , Mahriani Mahriani , Wiyono Hidayat Teguh 
Published: April 2021

Ginjal adalah organ ekskresi penting untuk membuang sisa metabolisme tubuh. Batu ginjal dapat mempengaruhi fungsi ginjal. Seledri mengandung senyawa flavonoid yang dapat memperbaiki struktur histologis ginjal. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak seledri terhadap struktur histologis ginjal yaitu diameter glomerulus dan tubulus dengan endapan protein. Penelitian ini merupakan penelitian eksperimental dengan Rancangan Acak Lengkap (RAL). Kelompok perlakuan dibagi menjadi 4 kelompok yaitu, kontrol negatif (K-), tikus hanya diberi makan dan minum; kontrol positif (K +), tikus diinduksi Etilen glikol (EG) 0.75% + Ammonium klorida (AK) 2%, dosis 1 (D1), tikus diinduksi EG 0.75% + AK 2% dan ekstrak seledri 100 mg / kg, dosis 2 ( D2), tikus diinduksi EG 0,75% + AK 2% dan ekstrak seledri 200 mg / kgBB. Pemberian ekstrak seledri selama 14 hari secara gavage. Ekstrak seledri dengan dosis 100 dan 200 mg / kgBB mampu memperbaiki struktur histologis ginjal tikus yang diinduksi oleh EG 0,75% dan AK 2%.
Kata kunci: seledri, diameter glomerulus, endapan protein
Kandungan Vitamin C dan Uji Organoleptik Lulur Rosella (Hibiscus sabdariffa L.)
Authors: Widyantari Ni Putu Sukma , Wirasiti Wirasiti , Wahyuni IGA Sugi 
Published: April 2021

Rosella tea is a ingredient that can be used for making scrubs because of its antioxidant content, but yet limited in cosmetic science. This research was aimed to find out the amount value of vitamin C and antioxidant activity in scrub that contains Rosella tea (Hibiscus sabdariffa L.) with variation of rice flour concentrations. This research was conducted at Analitic Laboratory, Faculty of Agricultural Technology and Soil Mechanical Laboratory, Faculty of Engineering, Udayana University from May until August 2018. The experiment was conducted using completely randomized design with seven treatments. Parameters observed were the amount values of vitamin C, antioxidant activities and organoleptic consists texture, colour, aroma and impression of Rosella scrub. The results of this results is the highest vitamin C and antioxidant content were found in rosella scrub with the percentage of 10% white rice flour and 80% red rice flour. The difference in body scrub treatment has a significant effect on proband judgments seen from the texture, color and aroma, while the difference in lulur treatment has no significant effect on proband judgments seen from the impression.

Keyword: scrub, Rosella, vitamin C, antioxidant, organoleptic
Analisis Filogenetik Cyprinus carpio Ruang Lingkup Asia Timur Dan Eropa Berdasarkan Genom Mitokondria
Authors: Putra Erik Nanda , Razak Abdul , Sumarmin Ramadhan 
Published: April 2021

Carp (Cyprinus carpio L.) is one of the oldest and most commercially cultivated freshwater fish in the World. However, there are still many undetermined phylogenetic relationships and the origins of common goldfish lineages, which are an obstacle to the conservation and genetic reproduction of this species. In the process of phylogenetic analysis, researchers used mitochondrial genomes where the genomic DNA was obtained from homozygous double haploid clonal lines from domesticated Songpu strains, and the total genomic DNA was extracted and sequenced using next-generation sequencing technology. Complete mitochondrial genome sequencing of 11 individuals representing East Asia and Europe and phylogenetic analysis was performed. The purpose of this study is to provide information about the phenology of Cyprinus carpio fish, which is expected to be the basis for increasing understanding to determine the kinship relationship between Cyprinus carpio in East Asia and Europe. The results showed that the relationship between Cyprinus carpio color, Cyprinus carpio songpu mirror carp, Cyprinus carpio carpio, and Cyprinus carpio wuyuanensis was very close, this can be seen from the bootstrap value of 100%. Meanwhile, with Cyprinus carpio haematopterus has a bootstrap value of 70%. Meanwhile, with Cyprinus xingguonensis it has a bootstrap value of 66%. Furthermore, it can also be said that the Songpu mirror goldfish is closely related to C. carpio carpio which is also a member of the genus Cyprinu. The genus Cyprinu has a close relationship with the genus Catla. In the phylogenetic tree, this species of fish forms a very coherent group, supported by a high bootstrap value of 100% and an average genetic distance of 0.02.
Key words: Mitochondrial genome, Phylogenetics, general Cyprinus carpio
Deteksi Level Antibodi Pada Serum Darah Anjing Kintamani Pasca Vaksinasi Rabies dengan Direct ELISA
Authors: Cahyana I Putu Agus Tirta , Pharmawati Made , Narayani Inna 
Published: April 2021

The success of rabies vaccination is characterized by the growth of seropositive antibody titers (?0.5 IU) after vaccination. One of the tests conducted to monitor antibody growth is ELISA (Enzyme Linked Immunosorbent Assay). This study aimed to determine the effect of different vaccine doses on the growth of rabies antibodies in kintamani dogs. The study was conducted using an experimental method with a study design using 2 variables, namely the difference in vaccine doses (0.5 and 0.75 cc) and the times of blood collection (1, 2 and 3 months after vaccination). Each vaccine dose was given to three kintamani dogs. Antibodies were measured using ELISA and data were analyzed with paired sample t-test between the treatment dose of 0.75 cc and 0.5 cc at months 1.2 and 3 after vaccination. The results showed that at first month the antibody titer were 2,12 IU at a dose of 0.75 cc and 3.72 IU at a dose of 0.5 cc. At second months, antibody titers were 7.74 IU (0.75 cc dose) and 10.85 IU (0.5 cc dose), while at third month, antibody titers were 5.73 IU (0.75 cc) and 9.00 IU (0.5 cc). Vaccine doses administered produce antibody titer levels that did not differ significantly between 0.75 cc and 0.5 cc doses.

Keyword: Antibody, ELISA, Kintamani Dog, Rabies
6. Chinese Papercut Poster Collection
Authors: Fu Qi 
Published: April 2021

For the past five months, I have been working on researching and digitizing a set of twenty-four Chinese papercut posters at W.D. Jordan Rare Books and Special Collections. Using the web publishing platform Omeka, the project combined the digital images of the papercut posters and all the metadata including title, translation, historical background and dimensions. This set of papercuts reflects the history of the Chinese revolution from the founding of the Chinese Communist Party to the establishment of People's Republic of China. This set includes the most representative events in all stages of the revolution creating a microcosm of the history of the Chinese people seeking liberation. Among these historical events, the majority of them were also displayed in the film “The East Is Red” which is a “song and dance epic” filmed in 1965 for celebrating the 15th anniversary of the founding of the People's Republic of China. The Chinese papercut posters online collection preserves and increases accessibility to these rare materials of which there is only one other collection online. By accessing to this site, more scholars can study this unique collection without time and location limitation.
Website Link: http://postercollection.omeka.net/collections/show/1
16. Optimizing Neurosurgical Drill Placement using the Microsoft HoloLens
Authors: Rae Emily 
Published: April 2021

Purpose: Tracked navigation systems require large carts of equipment, specialized technicians, and are impractical in bedside neurosurgical procedures. For bedside procedures like an opening of the skull for removing pressure caused by internal bleeding, navigation could improve the accuracy of the drill placement. We use the Microsoft HoloLens to display a hologram floating in the patient’s head to mark a drilling location on the skull. The accuracy of this placement is assessed to determine the feasibility of using the HoloLens to mark a drilling location within a clinically acceptable range.
Methods: A 3D model of the head is created from CT scans and imported to the HoloLens. The hologram is interactively registered to the patient and the drilling location is marked on the skull (Figure 1). 3DSlicer, Unity, and Visual Studio were used for implementing the software. The system was tested by 7 users. They each performed 6 registrations on phantoms with markers placed at 3 plausible drilling locations. Registration accuracy was determined by measuring the distance between the holographic and physical markers.
Results: Users placed 98% of the markers within the clinically acceptable range of 10 mm in an average time of 4:46 min.
Conclusion: It is feasible to mark a neurosurgical drilling location with clinically acceptable accuracy using the Microsoft HoloLens, within an acceptable length of time. This technology may also prove useful for procedures that require higher accuracy of location and drain trajectory such as the placement of external ventricular drains.
Caleb Wing and the Ninth Miniature: An Investigation into a Copied Manuscript Leaf and the Bibliophile Community in 19th Century England
Authors: Berry Abigail 
Published: April 2021

Buried within the famous Isabella Breviary, on the recto of page 37, there is a depiction of the circumcision of Christ. The miniature depicts Joseph and Mary on their knees, watching the circumcision of Christ being performed by a priest and another unrecognizable religious figure. Saying that this page is unknown to art historical scholarship is an understatement—the circumcision illumination in the breviary has never been referenced in scholarly writing.
Yet buried in an art collector’s house in the small city of Kingston Ontario, there is a beautifully detailed copy of the basically unknown circumcision leaf from the Isabella Breviary. The copy underwent chemical testing and it was revealed that the leaf was created in the 19th century. How did a copy of this unknown leaf end up in a small Canadian city? Who created this copy, and why? This presentation will explore the history, iconography and provenance of the Kingston Leaf. Although the Kingston Leaf is an almost direct copy of the original leaf in the Isabella Breviary, the small differences between the two pages provide clues that I believe connect the Kingston Leaf to the famous manuscript copier, Caleb Wing. But more importantly, the provenance reveals a community of 19th century English bibliophiles and art dealers, who were thinking about and evaluating medieval art. Their trades and deals surrounding the Kingston Leaf, and the Isabella Breviary, provide insight into the Gothic revival, and the Victorian romanticism of medieval art.
The choice of excipients to obtain tablets based on the Primula denticulate Smith. Extract by wet granulation
Authors: Shyrko A. Yu. , Vasenda M.M. , Будняк L.I. , Pokotylo O.O. 
Published: April 2021

Introduction. Herbal medicines are increasingly being used in the treatment of various diseases. Significant number of resources, high-level availability and the possibility of cultivation have provided high prospects of plant raw materials in the development of new herbal medicines. Primula denticulate Smith. is one of the most interesting medicinal plant raw materials source in modern medicine and pharmacy with the wide spectrum of pharmacotherapeutic action, that is mainly used only in traditional medicine. Thus, nowadays the development of new and effective medicines based on Primula denticulate Smith. in tablet dosage form is the topical task of pharmacy.
The aim of the work. To study the influence of excipients on the pharmaco­technological parameters of tablets with Primula denticulate Smith, are obtained by wet granulation method and to substantiate the choosing of the best excipients by the method of mathematical planning of the experiment.
Materials and Methods. It was used a self-prepared dense extract of Primula denticulate Smith. and excipients, which are complied with the requirements of State Pharmacopoeia of Ukraine in terms of pharmaco-technological quality parameters, for developing tablets. The hyper Greek-Latin square 4x4 was used to study the four qualitative factors.
Results and Discussion. In the course of the experiment, it was determined the dependence of pharmaco­technological parameters (friability, resistance to crushing and disintegration of tablets) on type of excipients. It was selected excipients with the optimal pharmaco-technological parameters for further research the tablets quality.
Conclusions.
According to the method of mathematical planning of the experiment, it’s chosen the optimal excipients for obtaining tablets based on dense extract of Primula denticulate Smith. Considering the investigated pharmaco-technological properties (friability, resistance to crushing and disintegration of tablets) the qualitative composition of excipients for obtaining tablets by the method of wet granulation was determined: Avicel PH - 105 and MCC 101, croscarmellose sodium, colloidal anhydrous silicon dioxide, magnesium stearate and Prosolv 90.
The study of the antidepressant and actoprotective activity of a synthetic analog of the terminal region of neuropeptide Y
Authors: Havrylov I. O. , Shtrygol’ S. Yu. 
Published: April 2021

Topicality. Neuropeptide Y (NPY), which is significantly widespread in the human body, is responsible for various physiological processes, in particular it is involved in the regulation of the emotional behavior, memory and metabolism. The modified short fragment of NPY proposed – NP9 nonapeptide for intranasal administration – shows certain biological properties of the native peptide, in particular the anxiolytic and antiamnesic action. The effect of NP9 on affective disorders of depressive nature and physical endurance remains unknown.
Aim. To study the antidepressant and actoprotective activity of NP9 in models of tail suspension, reserpine-induced depression, and forced weighted swimming.
Materials and methods. The antidepressant properties of NP9 were studied in the immobilization tail suspension test in mice and on a model of reserpine-induced depression with registration of the body temperature, ptosis, and behavior in the Porsolt forced swimming tests and the open field test. The actoprotective properties of NP9 were studied in the swimming test with a load (10 % of the weight of the animal).
Results and discussion. In the tail suspension test, NP9 significantly increased the latent time of the first immobilization compared to the indicators of intact animals (3.2 times) and the imipramine group (2.7 times). NP9 did not significantly affect the manifestations of reserpine-induced depression. These results indicate the weak antidepressant properties of NP9. Nonapeptide significantly increased the swimming time to exhaustion by 2.5 times, indicating actoprotective properties, according to which NP9 exceeded the reference drug Semax.
Conclusions. In the tail suspension test, nonapeptide NP9 exhibits dose-dependent antidepressant properties after the first administration, but this effect is practically not manifested in the rigid reserpine-induced model of depression. NP9 increases the physical endurance of animals in the forced weighted swimming test and is superior to the reference drug Semax by its effectiveness.
Methodological aspects of creating a soft dosage form with the antiviral effect
Authors: Hrytsenko V. I. , Kienko L. S. , Bobrytska L. O. , Zlagoda V. S. 
Published: April 2021

Aim. Substantiate the methodology of creating the soft dosage form for the treatment of herpes viral diseases, taking into account the existing requirements for pharmaceutical drug development.
Materials and methods. Drug creating is possible only with a theoretically and experimentally justified process of planning experimental research. To ensure the effectiveness and minimize side effects of the drug under development, it is necessary to take into account all pharmaceutical factors that have affect on the quality of the drug. These are the nature and quantity of the base, physical and chemical properties of active and auxiliary substances, structural and mechanical characteristics and equipment.
The methodological concept of antiviral drug development is based on the implementation of complexes of marketing, pharmaco-technological, physico-chemical and biopharmaceutical research, which ensures compliance of the drug with medical and biological requirements.
Results. It was found that the general algorithm of the methodological approach consists of 3 consecutive stages: information retrieval, research and standardization-pharmacological. Based on the analysis of literature sources and own research, a plan for creating of the soft dosage form with the antiviral effect based on acyclovir and miramistin was developed.
Conclusions. The main methodological aspects of creating the soft dosage form with antiherpetic action, taking into account the requirements for the quality of the drug are shown.
Key words: methodology; drug; research algorithm; soft dosage form
Acidente vascular cerebral isquêmico em paciente portador de forame oval pérvio: estudo de caso
Authors: Lemos Bárbara Alvim Raposo , Ochsendorf Fauzer Cury , Resende Maria Eduarda Calazans 
Published: April 2021

Objetivo: Relatar o caso de paciente portador de Forame Oval Pérvio (FOP), que evoluiu com Acidente Vascular Cerebral (AVC) criptogênico, correlacionando com os dados disponíveis na literatura acerca da fisiopatologia, quadro clínico, diagnóstico e tratamento. Detalhamento de caso: Paciente F.C.L., sexo masculino, 48 anos, sem comorbidades, apresentou episódio de visão turva associado com desvio de rima à esquerda e perda de força em membro superior esquerdo, com retorno em menos de 24 horas. Realizou ressonância magnética de crânio que comprovou AVC isquêmico. A ecocardiografia transesofágica confirmou o diagnóstico de FOP. Vários exames complementares foram realizados, mas não houve associação com outra etiologia. A conduta estabelecida foi a oclusão percutânea transcateter do forame, juntamente com tratamento medicamentoso. Considerações finais: É de suma importância o avanço nos estudos que englobam o AVC criptogênico e seu manejo, assim como sua associação com forame oval pérvio, já que o diagnóstico e tratamento interferem diretamente na sobrevida e na qualidade de vida do paciente.
Towards an Atomistic Understanding of Polymorphism in Molecular Solids
Authors: Sauza-de la Vega Arturo , Duarte Leonardo J. , silva arnaldo , Skelton Jonathan , Rocha-Rinza Tomás , Popelier Paul 
Published: April 2021

Many chemical phenomena are ultimately due to energy balances between atoms. In order to reach firm and clear conclusions one needs a reliable energy decomposition analysis (EDA). The Interacting Quantum Atoms (IQA) energy partitioning method is one of the most recent EDA methods. IQA is a topological energy partitioning that generates well-defined intra- and interatomic contributions, of steric, electrostatic or covalent (exchange) character. IQA has a minimal and powerful architecture and does not suffer from a number of conceptual and practical problems that plague the more traditional non-topological EDAs (Chem. Soc. Rev., 44 (2015) 3177).For the first time, our manuscript reports on a protocol for using the IQA to understand polymorphism, which we apply to the three polymorphs of succinic acid (SA), including the unusual polymorph that was recently discovered serendipitously (CrystEngComm, 20 (2018) 3971). The many intra- and interatomic energy terms from the EDA scheme are processed using a new technique that we developed called the Relative Energy Gradient (REG) method, which clearly identifies the atoms and corresponding energetic terms that govern the behaviour of the total system, in a minimal and unbiased way.
Особенности гормонального профиля пациенток с различными нозологическими вариантами дисгормональных заболеваний молочных желез в сравнении со здоровыми женщинами
Authors: Чайка В. К. , Ласачко С. А. 
Published: April 2021

Цель данного исследования — изучение некоторых особенностей гормонального профиля у пациенток с дисгормональными заболеваниями молочных желез (ДЗМЖ) репродуктивного возраста.Нами были обследованы 1057 пациенток с ДЗМЖ, которые соответствовали критериям включения/исключения. Пациентки были разделены на четыре группы в соответствии с нозологической формой заболевания молочных желез. Контрольную группу составили 147 условно здоровых женщин. Выполняли сбор анамнеза, ультразвуковое исследование молочных желез и ЩЖ, определение ряда гормонов (тиреотропный, свободные фракции тироксина и трийодтиронина, пролактин, гипофизарные и яичниковые гормоны) в сыворотке крови.После проведения целенаправленного скрининга в группах пациенток с ДЗМЖ доля патологии ЩЖ оказалась чрезвычайно высокой — 72,00%, что существенно выше (в 5 раз) в сравнении с контролем (р<0,001). Проведение углубленного обследования у пациенток с ДЗМЖ увеличило данный показатель в 3,8 раза по сравнению с данными, полученными только при сборе анамнеза.В группах пациенток с ДЗМЖ выявлен целый ряд достоверных отличий гормонального профиля в сравнении со здоровыми женщинами.Полученные результаты подтверждают существенную роль в патогенезе всех нозологических форм ДЗМЖ патологических изменений и нарушения функции ЩЖ, гиперпролактинемии, относительной и абсолютной гиперэстрогении и недостаточности лютеиновой фазы.На основании полученных данных считаем обоснованным и целесообразным проведение обследования состояния и функции ЩЖ, уровня пролактина, эстрадиола и прогестерона в лютеиновую фазу цикла в качестве скрининга для этой категории пациенток. Такое обследование позволит составить представление об индивидуальной патогенетической картине гормональных нарушений у каждой пациентки, и, соответственно, в дальнейшем провести коррекцию этих нарушений.
Investigation of the functional state changes of cardio-vascular system in patients, suffering peritonitis
Authors: Bilyayeva O. O. , Karol I. V. 
Published: April 2021

Objective. To study a functional state of cardio-vascular system in patients, suffering peritonitis.
Materials and methods. Analysis of dynamics in the electrocardiogram changes in 166 patients, including 84 women and 82 men, was conducted for studying of functional state of cardio-vascular system in extended peritonitis.
Results. Changes on electrocardiograms were non monotonous and depended on the peritonitis stage. In 28.3% patients diffuse changes in myocardium were observed, while in 43.9% - moderate. In 42.6% patients the disorders in metabolic processes in myocardium were revealed. Changes in conductivity and excitability were noted merely in half of the patients. Hypoxia was observed in 17.7% patients in reactive stage of peritonitis, in 32.0% - in a toxic, in 75.8% - in terminal. Tachycardia in a reactive stage of peritonitis was noted in 77.4% patients, in toxic one - in 89.3%, and in terminal - in 86.2% patients. In terminal stage of peritonitis in 13.8% patients bradycardia was noted. The blood supply disorders of various compartments of myocardium was revealed in 34.4% patients.
Conclusion. Functional changes of cardio-vascular system in patients depends on stage of peritonitis. In all the patients, suffering peritonitis, medicinal correction of the cardio-vascular system work must be conducted, while its intensity depends on stage of peritonitis.