bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recommendation system for finding improved coworking area based on intelligent information technologies
Authors: Kotciuba Igor Yurievich , Shikov Alexey Nikolaevich , Voitekhovsky Yuri 
Published: March 2021

Purpose
The purpose of this study is to make the implementation of a recommended Web service that allows one to formalize the search for a suitable coworking according to individual preferences as a decision-making task, as well as find a coworking area in an optimized setting for both the individual employee and those who carry out collective professional activities from a large number of alternatives in a shorter time.

Design/methodology/approach
In the implemented system of each place category in coworking areas, a search will be carried out according to formalized parameters and with an individual approach. To find the set of the required services of the coworking zone, the target functions of maximizing the priority of the place and minimizing the cost are determined, between which the user can set the ratio. As a constraint, the general fund of financial expenses for the time to reach the zone from different locations is used. The results of problem formalization are presented in the form of a mathematical model.

Findings
The use of a problem-oriented solution can significantly reduce the laboriousness of finding a suitable workspace.

Originality/value
The development of coworking zone practices contributes to the development of a professional infrastructure of the city and minimizes the cost of equipping each enterprise with additional tools, as well as manages labor resources and tracks trends of both professional and novice workers’ needs.
Application of photogrammetry in forensic pathology education of medical students in response to COVID‐19
Authors: Tóth Dénes , Petrus Karola , Heckmann Veronika , Simon Gábor , Poór Viktor Soma 
Published: March 2021

AbstractAs the coronavirus disease 2019 (COVID‐19) pandemic forced universities to switch to distance online education, there was an urgent need to find some virtual/digital alternatives in order to continue teaching. Opportunities such as watching pre‐recorded autopsy videos or creating and analyzing post‐mortem computed tomography or magnetic resonance imaging with various 3D surface imaging techniques are usually time‐consuming and cost‐intensive. Photogrammetry, which allows the creation of 3D textured surface models from a series of overlapping photographs taken from varying viewpoints, is a less common approach compared with post‐mortem imaging. We created 3D autopsy case models for a special online forensic pathology course in which students could try the models. Then, formal feedback was requested regarding the possible application of this method in education. Most of the students were satisfied with the new method and ranked photogrammetry higher than the other available methods. Our results indicate that photogrammetry has a high potential in undergraduate education, especially in the case of distance education or in those countries where declining autopsy rates have resulted in a decline in the use of the autopsy as an educational tool. Photogrammetry can also be used as a supplementary tool in traditional autopsy‐based education and has potential applications in various fields of medical education.
Liver and kidney function in patients with Covid‐19 treated with remdesivir
Authors: van Laar Sylvia A. , de Boer Mark G. J. , Gombert‐Handoko Kim B. , Guchelaar Henk‐Jan , Zwaveling Juliette ,   LUMC‐Covid‐19 research group
Published: March 2021

For the treatment of Covid‐19 patients with remdesivir, poor renal and liver function were both exclusion criteria in randomized clinical trials and contraindication for treatment. Also, nephrotoxicity and hepatotoxicity are reported as adverse events. We retrospectively reviewed renal and liver functions of Covid‐19 103 patients who received remdesivir in the 15 days after treatment initiation. Approximately 20% of the patient population met randomized clinical trial exclusion criteria. In total, 11% of the patients had a decrease in estimated glomerular filtration rate >10 mL/min/1.73m2. Also, 25 and 35% had increased alanine transaminase and aspartate transaminase levels, respectively. However, serious adverse events were limited. Therefore, based on these preliminary results, contraindications based on kidney and liver function should not be absolute for remdesivir treatment in patients with Covid‐19 if these functions are monitored regularly. A larger patient cohort is warranted to confirm our results.
Primary post‐transplant lymphoproliferative disorder of the central nervous system: characteristics, management and outcome in 25 paediatric patients
Authors: Taj Mary M. , Maecker‐Kolhoff Britta , Ling Rebecca , Bomken Simon , Burkhardt Birgit , Chiang Alan K. S. , Csoka Monika , Füreder Anna , Haouy Stéphanie , Lazic Jelena , Miakova Natalia , Minard‐Colin Veronique , Turner Suzanne D. , Uyttebroeck Anne , Attarbaschi Andishe ,   the European Intergroup for Childhood Non‐Hodgkin’s Lymphoma (EICNHL), the international Berlin‐Frankfurt‐Münster (i‐BFM) Study Group
Published: March 2021

SummaryPrimary central nervous system (CNS) post‐transplant lymphoproliferative disorder (PTLD) in childhood is rare. Twenty‐five patients were retrieved from nine European Intergroup for Childhood Non‐Hodgkin’s Lymphoma and/or international Berlin–Frankfurt–Münster Study Group members. Types of allografts included kidney (n = 11), liver (n = 4), heart (n = 5), bowel (n = 1) and haematopoietic stem cells (n = 4). Eighteen were male, 16 ≥ 10 years old, 21 had monomorphic disease and 24 solid intracranial tumour masses. Four‐year event‐free and overall survival rates were 50% ± 10% and 74% ± 9% respectively. This report represents the largest paediatric series of CNS PTLD reported to date, showing favourable survival odds following systemic and intrathecal chemotherapy and rituximab administration.
Glucagon‐like peptide‐1 (GLP‐1) receptor agonists and their cardiovascular benefits—The role of the GLP‐1 receptor
Authors: Helmstädter Johanna , Keppeler Karin , Küster Leonie , Münzel Thomas , Daiber Andreas , Steven Sebastian 
Published: March 2021

Cardiovascular outcome trials revealed cardiovascular benefits for type 2 diabetes mellitus patients when treated with long‐acting glucagon‐like peptide‐1 (GLP‐1) receptor agonists. In the last decade, major advances were made characterising the physiological effects of GLP‐1 and its action on numerous targets including brain, liver, kidney, heart and blood vessels. However, the effects of GLP‐1 and receptor agonists, and the GLP‐1 receptor on the cardiovascular system have not been fully elucidated. We compare results from cardiovascular outcome trials of GLP‐1 receptor agonists and review pleiotropic clinical and preclinical data concerning cardiovascular protection beyond glycaemic control. We address current knowledge on GLP‐1 and receptor agonist actions on the heart, vasculature, inflammatory cells and platelets, and discuss evidence for GLP‐1 receptor‐dependent versus independent effects secondary of GLP‐1 metabolites. We conclude that the favourable cardiovascular profile of GLP‐1 receptor agonists might expand their therapeutic use for treating cardiovascular disease even in non‐diabetic populations.LINKED ARTICLESThis article is part of a themed issue on GLP1 receptor ligands (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.4/issuetoc
Synthesis of 2‐Chloro‐3‐amino indenone derivatives and their evaluation as inhibitors of DNA dealkylation repair
Authors: Nigam Richa , Raveendra Babu Kaki , Ghosh Topi , Kumari Bhavini , Das Prolay , Anindya Roy , Ahmed Khan Faiz 
Published: March 2021

AbstractDNA alkylation damage, emanating from the exposure to environmental alkylating agents or produced by certain endogenous metabolic processes, affects cell viability and genomic stability. Fe(II)/2‐oxoglutarate‐dependent dioxygenase enzymes, such as Escherichia coli AlkB, are involved in protecting DNA from alkylation damage. Inspired by the natural product indenone derivatives reported to inhibit this class of enzymes, and a set of 2‐chloro‐3‐amino indenone derivatives was synthesized and screened for their inhibitory properties against AlkB. The synthesis of 2‐chloro‐3‐amino indenone derivatives was achieved from 2,3‐dichloro indenones through addition–elimination method using alkyl/aryl amines under catalyst‐free conditions. Using an in vitro reconstituted DNA repair assay, we have identified a 2‐chloro‐3‐amino indenone compound 3o to be an inhibitor of AlkB. We have determined the binding affinity, mode of interaction, and kinetic parameters of inhibition of 3o and tested its ability to sensitize cells to methyl methanesulfonate that mainly produce DNA alkylation damage. This study established the potential of indenone‐derived compounds as inhibitors of Fe(II)/2‐oxoglutarate‐dependent dioxygenase AlkB.
Long term clinical performance of 10 871 dental implants with up to 22 years of follow‐up: A cohort study in 4247 patients
Authors: French David , Ofec Ronen , Levin Liran 
Published: March 2021

AbstractBackgroundThe present retrospective study was aimed to assess the long‐term clinical performance of dental implants in a cohort study of 4247 patients.MethodsA longitudinal observational cohort study was done on all implants performed by a single periodontist from July 1995 to April 2019. The main outcome variables of this study were implant failure and marginal bone level around implants.ResultsThe study participants received a total of 10 871 implants with a mean of 2.56 implants per patient. The cohort was followed‐up to 22.2 years (mean = 4.5 ± 4.2). Among the 4247 patients of the current study, 140 patients (3.3%) experienced a combined total of 178 implant failures. According to life table analysis, at the implant level the cumulative survival rate at 3, 5, 10, and 15 years was 98.9%, 98.5%, 96.8%, and 94.0%, respectively while at patient level was 97.4%, 96.7%, 92.5%, and 86% at 3, 5, 10, and 15 years. Patients with multiple units were at a greater risk for having an implant failure. Baseline bone level was 0.09 ± 0.28 mm while at 8–10 years the mean bone level was 0.49 ± 0.74 mm. The incidence of peri‐implant mucositis at the implant level was 9.4% at 2–3 years, 9.3% at 4–5 years, 12.1% at 6–7 years, and 11.9% at 8–10 years. The incidence of peri‐implantitis was 2%, 2.6%, 3.2%, and 7.1% at 2–3, 4–5, 6–7, and 8–10 years, respectively. Cigarette smoking and diabetes mellitus were positively correlated with implant failure.ConclusionsThough the results are promising and encouraging in terms of survival and bone level over time, it is important to emphasize the potential risk factors and consider them prior to dental implant placement.
An evaluation of the safety and preliminary efficacy of peri‐ and post‐operative treprostinil in preventing ischemia and reperfusion injury in adult orthotopic liver transplant recipients
Authors: Almazroo Omar Abdulhameed , Miah Mohammad Kowser , Pillai Venkateswaran C. , Shaik Imam H. , Xu Ruichao , Dharmayan Stalin , Johnson Heather J. , Ganesh Swaytha , Planinsic Raymond M. , Demetris Anthony J , Al‐Khafaji Ali , Lopez Roberto , Molinari Michele , Tevar Amit D. , Hughes Christopher , Humar Abhinav , Venkataramanan Raman 
Published: March 2021

AbstractBackgroundOrthotopic liver transplantation (OLT) is the only treatment option for various end‐stage liver diseases. Ischemia and reperfusion (I/R) injury is one of the unavoidable complications/conditions in OLT. In 2019, a total of 8896 livers were transplanted of which >94% organs were procured from deceased donors. An increase in the use of extended criteria donor (ECD) livers for transplantation further unraveled the role of hepatic I/R injury on short‐term and long‐term graft outcomes. Despite promising outcomes with the use of antioxidants, free radical scavengers, and vasodilators; I/R‐mediated liver injury persists and significantly influences the overall clinical outcomes. Treprostinil, a synthetic prostacyclin I2 (PGI2) analog, due to its vasodilatory property, antiplatelet activity, and its ability to downregulate pro‐inflammatory cytokines can potentially minimize I/R injury.AimWe investigated the safety and preliminary efficacy of continuous intravenous infusion of treprostinil in liver transplant recipients in a prospective, single‐center, non‐randomized, interventional study.Material and methodsThis was a dose escalation (3 + 3 design) phase 1/2 study. Deceased donor liver transplant recipients received 5 ng/kg/min for two days, or 2.5, 5, and 7.5 ng/min/kg for 5 days as a continuous infusion. Multiple blood samples were collected for biochemical parameter assessment and for measuring treprostinil levels. Indocyanine green plasma disappearance rate was used as a measure of hepatic functional capacity.ResultsSubjects tolerated continuous infusion of treprostinil up to 5 ng/kg/min for 120 h with no occurrence of primary graft non‐function (PNF), minimized need for ventilation support, reduced hospitalization time, 100% graft and patient survival, and improved hepatobiliary excretory function comparable to normal healthy adults.DiscussionTreprostinil can be administered to liver transplant patients safely during the perioperative period.ConclusionBased on this phase 1/2 study, further efficacy studies of treprostinil in preventing I/R injury of liver should be conducted to potentially increase the number of livers available for transplantation.
Precision medicine for genetic childhood movement disorders
Authors: Soo Audrey K S , Ferrini Arianna , Kurian Manju A 
Published: March 2021

Increasingly effective targeted precision medicine is either already available or in development for a number of genetic childhood movement disorders. Patient‐centred, personalized approaches include the repurposing of existing treatments for specific conditions and the development of novel therapies that target the underlying genetic defect or disease mechanism. In tandem with these scientific advances, close collaboration between clinicians, researchers, affected families, and stakeholders in the wider community will be key to successfully delivering such precision therapies to children with movement disorders.
What this paper adds

Precision medicine for genetic childhood movement disorders is developing rapidly.

Accurate diagnosis, disease‐specific outcome measures, and collaborative multidisciplinary work will accelerate the progress of such strategies.
Visual processing speed is linked to functional connectivity between right frontoparietal and visual networks
Authors: Küchenhoff Svenja , Sorg Christian , Schneider Sebastian C. , Kohl Oliver , Müller Hermann J. , Napiórkowski Natan , Menegaux Aurore , Finke Kathrin , Ruiz‐Rizzo Adriana L. 
Published: March 2021

AbstractVisual information processing requires an efficient visual attention system. The neural theory of visual attention (TVA) proposes that visual processing speed depends on the coordinated activity between frontoparietal and occipital brain areas. Previous research has shown that the coordinated activity between (i.e., functional connectivity and “inter‐FC”) cingulo‐opercular (COn) and right‐frontoparietal (RFPn) networks is linked to visual processing speed. However, how inter‐FC of COn and RFPn with visual networks links to visual processing speed has not been directly addressed yet. Forty‐eight healthy adult participants (27 females) underwent resting‐state (rs‐)fMRI and performed a whole‐report psychophysical task. To obtain inter‐FC, we analyzed the entire frequency range available in our rs‐fMRI data (i.e., 0.01–0.4 Hz) to avoid discarding neural information. Following previous approaches, we analyzed the data across frequency bins (Hz): Slow‐5 (0.01–0.027), Slow‐4 (0.027–0.073), Slow‐3 (0.073–0.198), and Slow‐2 (0.198–0.4). We used the mathematical TVA framework to estimate an individual, latent‐level visual processing speed parameter. We found that visual processing speed was negatively associated with inter‐FC between RFPn and visual networks in Slow‐5 and Slow‐2, with no corresponding significant association for inter‐FC between COn and visual networks. These results provide the first empirical evidence that links inter‐FC between RFPn and visual networks with the visual processing speed parameter. These findings suggest that direct connectivity between occipital and right frontoparietal, but not frontoinsular, regions support visual processing speed.
Carbon cycle inverse modeling suggests large changes in fractional organic burial are consistent with the carbon isotope record and may have contributed to the rise of oxygen
Authors: Krissansen‐Totton Joshua , Kipp Michael A. , Catling David C. 
Published: March 2021

AbstractAbundant geologic evidence shows that atmospheric oxygen levels were negligible until the Great Oxidation Event (GOE) at 2.4–2.1 Ga. The burial of organic matter is balanced by the release of oxygen, and if the release rate exceeds efficient oxygen sinks, atmospheric oxygen can accumulate until limited by oxidative weathering. The organic burial rate relative to the total carbon burial rate can be inferred from the carbon isotope record in sedimentary carbonates and organic matter, which provides a proxy for the oxygen source flux through time. Because there are no large secular trends in the carbon isotope record over time, it is commonly assumed that the oxygen source flux changed only modestly. Therefore, declines in oxygen sinks have been used to explain the GOE. However, the average isotopic value of carbon fluxes into the atmosphere–ocean system can evolve due to changing proportions of weathering and outgassing inputs. If so, large secular changes in organic burial would be possible despite unchanging carbon isotope values in sedimentary rocks. Here, we present an inverse analysis using a self‐consistent carbon cycle model to determine the maximum change in organic burial since ~4 Ga allowed by the carbon isotope record and other geological proxies. We find that fractional organic burial may have increased by 2–5 times since the Archean. This happens because O2‐dependent continental weathering of 13C‐depleted organics changes carbon isotope inputs to the atmosphere–ocean system. This increase in relative organic burial is consistent with an anoxic‐to‐oxic atmospheric transition around 2.4 Ga without declining oxygen sinks, although these likely contributed. Moreover, our inverse analysis suggests that the Archean absolute organic burial flux was comparable to modern, implying high organic burial efficiency and ruling out very low Archean primary productivity.
Long‐term efficacy and safety during open‐label erenumab treatment in Japanese patients with episodic migraine
Authors: Sakai Fumihiko , Takeshima Takao , Tatsuoka Yoshihisa , Hirata Koichi , Cheng Sunfa , Numachi Yotaro , Peng Cheng , Xue Fei , Mikol Daniel D. 
Published: March 2021

AbstractObjectiveTo assess long‐term (up to 2 years) efficacy, tolerability, and safety of erenumab for the prevention of episodic migraine (EM) in Japanese patients.BackgroundPreviously published results from the double‐blind treatment phase (DBTP) of a phase 2 clinical study have demonstrated the efficacy and safety of erenumab in Japanese patients with EM.MethodsPatients completing the 24‐week placebo‐controlled DBTP could continue into the 76‐week open‐label treatment phase (OLTP), receiving erenumab 70 mg or 140 mg subcutaneously once monthly. The initial dose in the OLTP was erenumab 70 mg monthly, which was later changed to 140 mg. After study completion, the following were assessed: change from baseline in monthly migraine days (MMD), change from baseline in monthly acute migraine‐specific medication days (MSMD), percentage of patients achieving ≥50% and ≥75% reduction in MMD, change from baseline in the 6‐item Headache Impact Test (HIT‐6™) score, and safety (exposure‐adjusted patient‐incidence of adverse events [AEs], calculated as number of patients per 100 patient‐years).ResultsOf 475 patients enrolled in the DBTP, 459 (96.6%) continued in the OLTP. The mean (SD) MMD was 7.9 (2.3) at baseline with the overall change from baseline at week 100 of –2.9 (4.1) days. The monthly acute MSMD was 5.7 (2.8) at baseline with change from baseline at week 100 of −1.7 (3.7) days. The proportion of patients who achieved ≥50% and ≥75% reduction in MMD from baseline at week 100 was 177/398 (44.5%) and 94/398 (23.6%), respectively. The HIT‐6™ score was 58.4 (5.4) at baseline with a change of −6.4 (8.2) at week 100. The exposure‐adjusted patient‐incidence of AEs during the OLTP was 207.1/100 patient‐years for the combined erenumab group, similar to that observed for either erenumab (271.0/100 patient‐years) or placebo (257.3/100 patient‐years) during the DBTP, and no new safety signals were detected during the OLTP.ConclusionLong‐term erenumab treatment in Japanese patients with EM demonstrated sustained efficacy for up to 2 years, with a safety profile similar to previous studies, supporting erenumab as a potential new therapy for EM prevention in Japan.
Failure to eradicate Helicobacter pylori infection is more frequent among HIV‐positive patients
Authors: Nkuize M , Vanderpas J , Buset M , Delforge M , Cadière G‐B , De Wit S 
Published: March 2021

ObjectivesHelicobacter pylori is a worldwide infection, but little is known about the efficacy of treatment for H. pylori infection in HIV‐positive patients. The goal of this work was to evaluate outcomes after first‐line H. pylori treatment and identify risk factors for failure in HIV‐positive patients.MethodsThis registry study of unmatched H. pylori‐infected HIV‐positive patients and HIV‐negative obese pre‐bariatric surgery controls was performed in a tertiary university hospital. Cases were enrolled from 2006 to 2017, controls from 2007 to 2014, and both received standard of care. An additional ‘optimal’ subgroup of cases was enrolled prospectively from 2017 to 2019 which was treated only on the basis of antibiogram, drug interaction search and additional support by one referent physician. Helicobacter pylori eradication failure rates were compared according to clinical, microbiological and pathological parameters and treatment.ResultsWe analysed 258 HIV‐positive patients and 204 HIV‐negative control patients. Helicobacter pylori eradication failure rates were markedly greater in cases (24.1%) than in controls (8.8%). The proportions of levofloxacin and metronidazole resistance were greater in cases than in controls (P < 0.05). Among cases treated with H. pylori triple therapy (S3T), the ‘optimal’ subgroup experienced a 9.5% failure rate vs. 28.6% with other strategies (P = 0.01). Risk factors for failure were H. pylori treatment strategy, exposure to antiretroviral treatment, and alcohol status. Overall, positive HIV status was a risk factor for S3T eradication failure.ConclusionsPatients co‐infected with H. pylori and HIV frequently failed to eradicate H. pylori and this was related to treatment strategy, antiretroviral exposure and lifestyle.