bluuebunny/crossref_metadata_2025_split huggingface dataset:
How does benefit finding evolve over time among Chinese women breast cancer survivals: a longitudinal study
Authors: Bi Weiyun , Wang Huaning , Yang Guitao , Zhu Cailin 
Published: March 2021

Abstract
Objective: Even though the prevalence of benefit finding (BF) has been empirically shown to exist among breast cancer (BC) survivals, how does benefit finding evolve over time remains inadequately investigated. This objective of this study is to examine how BF evolves over time among Chinese breast cancer survivals and determine the demographic, medical and psychosocial factors that can sustain BF increase over time, thus bring about higher level of long-term post-traumatic growth among breast cancer survivals.

Methods: Participants were 486 women with different stages of breast cancer (stages I, II and III) followed from completion of primary treatment. Analysis were performed on the data collected at the 3-year assessment during 2014-2019. Participants completed self-report questionnaires of characteristics and benefit finding at six time points with the interval of six months since BC diagnosis. The relationships between demographic, medical and psychosocial characteristics and benefit finding evolution over time were examined using mixed models.

Results: Participants reported mixed results on the evolving patterns of benefit finding: 28% reported an upward trend in BF scoring over time, 49% instead reported an downward trend, and the remaining 23% reported no obvious change. Our study has shown that some well-known covariates of benefit finding, e.g. education, income, and social support, are not associated with BF trends. In comparison, levels of spirituality and disease coping at diagnosis can more reliably predict BF evolution over time. Our results strongly indicate that benefit finding can be sustained and increased by encouraging attempts at meaning-making and active disease coping during breast cancer treatment. To our knowledge, this study is among the first to examine trends of benefit finding evolution over time on breast cancer survivals and determine their psychosocial predictors in developing countries.

Conclusion: Identifying the sustaining factors of benefit finding in the experience of breast cancer is the key to design psycho clinical solutions for patients’ long-term post-traumatic growth. As time goes by, cancer patients may experience less benefit finding. However, active disease coping and meaning-making by patients can effectively counter this undesired trend and boost their higher long-term post-traumatic growth.
Controlled-Synthesis of Hierarchical NiCo2O4 Anchored on Carbon Nanofibers Mat for Free-Standing and Highly-Performance Supercapacitors
Authors: Elshafei Mohamed , Deen Ahmed Gamal  El , Elmoneim Ahmed Abd , Hessein Amr 
Published: March 2021

Abstract
In this work, a versatile one-step hydrothermal technique was used to produce a hybrid standalone electrode of NiCo2O4 hierarchical nanostructures anchored on CNFs mat for highly-performance and substrate-free supercapacitors. The CNFs mat was working as a conductive and a three-dimensional template for hierarchical NiCo2O4 nanostructures deposition at the same time. The morphological and structural data analysis revealed a pure spinel NiCo2O4 nanostructures with a unique surface morphology comprising interconnected ultrathin nanoneedles and nanoflowers were successfully anchored to the CNFs mat. Real supercapacitors consist of two-symmetrical hybrid electrodes with different NiCo2O4 loading ratios were assembled and tested. The electrochemical performances of the assembled devices in terms of specific capacitance, energy, and power densities were systematically evaluated. Increasing the NiCo2O4 loading on the CNFs mat had shown a positive impact on improving the overall electrochemical performance of the assembled supercapacitors. A hybrid electrode loaded with NiCo2O4 twice as much as CNFs possess a specific capacitance value of 540 F g−1 along with an energy density of 30 Wh kg−1 at a power density of 515.6 W kg−1. In addition, the device showed excellent cycling stability and high capacitance retention against 6000 charge-discharge cycles at a charging current of 1.0 A g−1.
Institutions Powers, financial development and environmental factors influence on Carbon emission: Evidence from a Global Perspective
Authors: khan hayat , weili Liu , khan itbar 
Published: March 2021

Abstract
This study explores the moderating power of institutional quality on carbon emission through renewable energy consumption, foreign direct investment, economic growth and financial development in the globe for the period of 2002 to 2019. By using two Step System Generalized Method of Moments, the results illustrate that renewable energy usage and foreign direct investment inflow enhance environmental quality while financial development and economic growth lowers environmental quality in the panel. The results shows that quality institutions in countries are still not yet adequate to defend the harmful impact of every environmental factor and protect environment however, the interaction term of institutional quality confirms the significant moderating effect of all explanatory variables on environmental quality in the panel. The findings also confirm the existence of Environmental Kuznets Curve and evidence the pollution halo hypothesis. The findings of this paper can be useful for policy makers whereas conducting stricter environmental regulation.
Antimicrobial-associated Organ Injury among the Older Adults: A Systematic Review and Meta-Analysis
Authors: Chinzowu Tichawona , Roy Sandipan , Nishtala Prasad S 
Published: March 2021

Abstract
Background: Older adults (aged 65 years and above) constitute the fastest growing population cohort in the western world. There is increasing evidence that the burden of infections disproportionately affects older adults, and hence this vulnerable population is frequently exposed to antimicrobials. There is currently no systematic review summarising the evidence for organ injury risk among older adults following antimicrobial exposure. This systematic review and meta-analysis examined the relationship between antimicrobial exposure and organ injury in older adults. Methodology: We searched for Psych INFO, PubMed, and EMBASE databases for relevant articles using MeSH terms where applicable. After removing duplicates, articles were screened for inclusion into or exclusion from the study by two reviewers. The Newcastle-Ottawa scale was used to assess the risk of bias for cohort and case-control studies. The Cochrane collaboration's tool for risk of bias (version 2) was used to assess the risk of bias for randomised control trials. We explored the heterogeneity of the included studies using the Q test and I2 test and the publication bias using the funnel plot and Egger's test. Results: The overall absolute risks of acute kidney injury among older adults prescribed aminoglycosides, glycopeptides, and macrolides were 15.1%, 19.1%, and 0.3%, respectively. Only 3 studies reported antimicrobial associated drug-induced liver injury. Studies reporting on the association of organ injury and antimicrobial exposure by age or duration of treatment were too few to meta-analyse. The funnel plot and Egger's tests did not indicate evidence of publication bias.Conclusion: Older adults have a significantly higher risk of sustaining acute kidney injury when compared to the general adult population. Older adults prescribed aminoglycosides have a similar risk of acute kidney injury to the general adult population.
The Nature of Infill Material on the Discontinuities of the Muntele Mare Granite (Beliş-Fantânele, Romania)
Authors: Har Nicolae , Gheorghiu Robert 
Published: March 2021

Abstract
The stability of rock massifs is strongly influenced by natural degradation processes. In combination with hydrothermal activity or atmospheric exposure, rock alteration processes can lead to the formation of secondary phases that ultimately control the rock quality and slope stability, which are particularly important for engineering works (e.g., road cuts, open pits, quarries, tunnels). The Bozgai open quarry in the Muntele Mare granite massif in the northern Apuseni Mountains (Romania) offers an excellent opportunity to investigate the influence of alteration processes on rock properties, especially owing to the extensive exposure of granite and specific mineral assemblages of hydrothermal genesis to atmospheric conditions. The alteration processes generated secondary phases located on the primary minerals of the affected rocks or deposited as infill material along the granite discontinuities. Natural and oriented samples of the Bozgai quarry infill material were investigated using polarized light, X-ray diffraction, and scanning electron microscopy to obtain images and identify their mineralogical composition. The hydrothermal vein material consists of kaolinite, illite, pyrite, marcasite, quartz, iron hydroxides, albite, and microcline. These samples were exposed to atmospheric oxygen and meteoric water and secondary sulphates (jarosite and gypsum) formed in an acidic environment generated by the oxidization of pyrite and marcasite. The sheeted structure of kaolinite and geochemical behavior of the sulphates in the presence of water play a particularly important role in the reduced rock slope stability in the Bozgai quarry.
Do Equidistant Energy Levels Necessitate a Harmonic Potential?
Authors: Teichert Fabian , Kuhn Eduard , Thränhardt Angela 
Published: March 2021

Abstract
Experimental results from literature show equidistant energy levels in thin Bi films on surfaces, suggesting a harmonic oscillator description. Yet this conclusion is by no means imperative, especially considering that any measurement only yields energy levels in a finite range and with a nonzero uncertainty. Within this study we review isospectral potentials from the literature and investigate the applicability of the harmonic oscillator hypothesis to recent measurements. First, we describe experimental results from literature by a harmonic oscillator model, obtaining a realistic size and depth of the resulting quantum well. Second, we use the shift-operator approach to calculate anharmonic non-polynomial potentials producing (partly) equidistant spectra. We discuss different potential types and interpret the possible modeling applications. Finally, by applying n th o rder perturbation theory we show that exactly equidistant eigenenergies cannot be achieved by polynomial potentials, except by the harmonic oscillator potential. In summary, we aim to give an overview over which conclusions may be drawn from the experimental determination of energy levels and which may not.
Loss of REST in Breast Cancer Promotes Tumor Progression Through Estrogen Sensitization, MMP24 and CEMIP Overexpression.
Authors: Cloud Ashley S , Vargheese Aditya M , Gunewardena Sumedha , Shimak Raeann M , Ganeshkumar Sornakala , Kumaraswamy Easwari , Jensen Roy A , Chennathukuzhi Vargheese M 
Published: March 2021

Abstract
Background: Breast cancer is the most common malignancy in women, and is both pathologically and genetically heterogeneous, making early detection and treatment difficult. A subset of breast cancers express normal levels of REST (repressor element 1 silencing transcription factor) mRNA but lack functional REST protein. Loss of REST function is seen in ~20% of breast cancers and is associated with a more aggressive phenotype and poor prognosis. Despite the frequent loss of REST, little is known about the role of REST in the molecular pathogenesis of breast cancer.Methods: TCGA data was analyzed for the expression of REST target genes in breast cancer patient samples. We then utilized gene knockdown in MCF-7 cells in the presence or absence of steroid hormones estrogen and/ progesterone followed by RNA sequencing, as well as chromatin immunoprecipitation and PCR in an attempt to understand the tumor suppressor role of REST in breast cancer. Results: We show that REST directly regulates CEMIP (cell migration-inducing and hyaluronan-binding protein, KIAA1199) and MMP24 (matrix metallopeptidase 24), genes known to have roles in invasion and metastasis. REST knockdown in breast cancer cells leads to significant upregulation of CEMIP and MMP24. In addition, we found REST binds to RE-1 sites (repressor element-1) within the genes and influences their transcription. Furthermore, we found that the estrogen receptor (ESR1) signaling pathway is activated in the absence of REST, regardless of hormone treatment.Conclusions: We demonstrate a critical role for the loss of REST in aggressive breast cancer pathogenesis and provide evidence for REST as an important diagnostic marker for personalized treatment plans.
Large Plasmonic Resonance Shifts From Metal Loss in Slits
Authors: Sharifi Zohreh , Gordon Reuven 
Published: March 2021

Abstract
The impact of loss on the plasmonic resonances in metal-insulator­metal slits is analyzed, particularly the signiﬁcant effect of loss on the reﬂection phase. The reﬂection is calculated analytically using single mode matching the­ory with the unconjugated form of the orthogonality relation. This theoretical calculation agrees well with comprehensive simulations, but differs substan­tially from the conjugated orthogonality result, as was used in past analytical works. This reﬂection phase has a large impact on the plasmonic resonance wavelengths, which are calculated using a Fabry-Pérot theory and compared with past experiment and ﬁnite-difference time-domain simulations.
Kink-Soliton, Singular-Kink-Soliton and Singular-Periodic Solutions for a New Two-Mode Version of the Burger-Huxley Model: Applications in Nerve Fibers and Liquid Crystals
Authors: Alquran Marwan , Sulaiman Tukur Abdulkadir , Yusuf Abdullahi 
Published: March 2021

Abstract
New two-mode version of Burger-Huxley equation is derived using Korsunsky's operators. The new model arises in the applications of nerve fibers and liquid crystals and describes the interaction of two symmetric waves moving simultaneously in the same direction. Kink-soliton, singular-kink-soliton and singular-periodic solutions are obtained to this model by means of the simplified bilinear method, polynomial-function method and the Kudryashov-expansion method. A comprehensive graphical analysis is conducted to show the physical aspects of this new type of nonlinear equations. Finally, all obtained solution are verified by direct substitution in the model.
Laser Performance and Investigation the Optimal Density Functional and the Dependence of the Basis Sets for (E, E)-2, 5-bis (3, 4-Dimethoxystyryl) Pyrazine (BDP) Molecule.
Authors: sakr mahmoud , Gawad Sayed Abdel , Eldaly Samy , Kana Maram Abou , Ebeid El-Zeiny 
Published: March 2021

Abstract
This manuscript includes some photophysical parameters and some optical properties such as absorption and emission spectra of the (E, E)- 2,5-bis (3,4-dimethoxystyryl) pyrazine (BDP) by applying sol-gel and copolymer matrices. The BDP molecular structure is incorporated in sol-gel matrix and copolymer of methyl methacrylate (MMA) and 2-hydroxy metylmethacrylate (HEMA). In case of sol-gel matrix, the BDP molecular structure has higher quantum yield in addition to photostability maxima. The laser behavior of this molecular structure containing sol-gel matrix is good senior compared to copolymer one via using diode laser (450nm) as pumping laser of power 160 mW. Also, the fluorescence profile of the BDP molecular structure is sensitized via using cadmium sulphide (CdS) quantum dots (QDs) by applying sol-gel host. The optimized structure of the BDP molecule is obtained via applying B3LYP/6-31G(d) level of theory. The electronic absorption and emission spectra of the BDP molecular structure in ethanol solvent, were calculated using time dependent density functional theory (TDDFT) at CAM-B3LYP /6-31G++(d, p) level. The obtained theoretical results were compared to experimental ones.
Needs Assessment For Continuing Professional Education Among Aesthetic Plastic Surgeons: Evidence From An Economically Developed Region in China
Authors: Qiu Jun , Yi Yanhua , Jia James , Miao Yong , Hu Zhiqi 
Published: March 2021

Abstract
Background: This study aims to survey the demographic status of aesthetic plastic surgeons in an economically developed region and to investigate their continuing professional education needs in contents, training methods, and barriers in private and public hospitals. Methods: A cross-sectional survey with a self-administered questionnaire was conducted from January to December, 2020 in Guangdong, China. An in-depth key informant interviews were conducted to gain insights on the current demographic status. Demographic data and training needs assessment were collected and compared with the chi-square test, Fisher’s test, Mann-Whitney U-test using R software. Results: The disparity of surgeons’ demographic data between private and public hospitals was small. Over 60% of practicing aesthetic plastic surgeons transferred from other specialties, and one third of them had less than three years of working experience. Half surgeons attended training less than three times with an affordable expense of 1000-5000RMB. Almost 80% of them had strong willingness to attend a continuing professional education program. They prefer to attending further study in a tertiary hospital, short topic-focused training course with operation demonstrations. Their favorable training contents were rhinoplasty, eye surgery, and new technologies. Questionnaire survey revealed the likelihood that the surgeons had a graduate degree in public hospitals outweighed those in private hospitals (P<0.05). In-depth interview showed that the public hospitals focused more on repair and reconstructive surgery, academic research, whereas, private hospitals focused on market needs and were more profit-driven, where the organizational needs had influence on their different training needs for aesthetic plastic surgeons.Conclusion: It would be favorable to take the demographic status of aesthetic plastic surgeons and organizational needs into consideration in designing a continuing professional education program in plastic surgery.
Comparison of Survivors and Nonsurvivors of Diffuse Alveolar Hemorrhage: Risk Factors for In-hospital Death
Authors: Sangli Swathi , Baqir Misbah , Ryu Jay 
Published: March 2021

Abstract
ObjectiveThe objective of this study was to identify the predictors of in-hospital mortality among patients with diffuse alveolar hemorrhage (DAH).Patients and MethodsWe conducted a retrospective review of 89 patients hospitalized for DAH at our institution between 2001 and 2017: 49 patients who died during hospitalization and 40 patients who survived were compared. We reviewed their presenting signs and symptoms, clinical course, radiologic and pathologic findings, along with medical management. We then performed univariate and multivariate analyses to identify the risk factors associated with in-hospital mortality.ResultsWe identified 12 factors to be associated with mortality when comparing survivor vs non-survivor cohorts: smoking (27 [67%] vs 21 [42%], p = 0.02), malignancy (7 [17%] vs 24 [49%], p = 0.002), interstitial lung disease (0 vs 7 [14%], p = 0.01), liver failure (1 [2%] vs 14 [28%], p = 0.001), autoimmune diseases (16 [40%] vs 4 [8%], p =0.0006), thrombocytopenia (3 [7%] vs 35 [71%], p <0.0001), ICU admission (23 [57%] vs 40 [85%], p=0.004), mean duration of ICU stay (3.5 days [± 6.7] vs 5.5 days [± 5.5], p = 0.4), steroid use (36 [90%] vs 31 [63%], p = 0.003), use of plasma exchange (6 [15%] vs 0, p = 0.005), use of mechanical ventilation (15 [37%] vs 36 [75%], p value = 0.0007) and development of acute respiratory distress syndrome (ARDS) (9 [22%] vs 37 [77%], p <0.0001), respectively. On multivariate analysis, thrombocytopenia (OR 52.08: 95% CI, 8.59-315.71; p <0.0001) and ARDS (OR 11.71: 95% CI, 2.60-52.67; p = 0.0013) were associated with higher odds of mortality in DAH while steroid use (OR 0.05: 95% CI, 0.007-0.39; p = 0.0004) was associated with a lower risk of in-hospital mortality in patients with DAH.ConclusionIn DAH, thrombocytopenia and ARDS were predictors of in-hospital mortality whereas the use of steroid was associated with a more favorable prognosis.
Novel Pathogenic Mutations of FERMT1 in two Chinese Kindler Syndrome Families
Authors: Li Min , Li Weisheng , Zhu Dan , Lu Likui , Liu Jingliu , Shi Yajun , Lin Zhimiao , Sun Miao 
Published: March 2021

Abstract
Background: Kindler syndrome (KNDLRS) is a very rare autosomal recessive disorder characterized by bullous poikiloderma with photosensitivity. Loss-of-function mutations in FERMT1, which located on chromosome 20p12.3, were responsible for KNDLRS. Numerous mutations in FERMT1 have been reported to be associated with KNDLRS. Results: The present study reported two Chinese KNDLRS families, and affected individuals from both families presented with poikiloderma, palmoplantar hyperkeratosis, and diffuse cigarette paper like atrophy on hands. Skin biopsy of the proband from family 2 showed atrophy of epidermis, hyperkeratosis, dilated blood vessels in upper dermis, and microbubbles at the dermis and epidermis junction. Medical Whole Exome Sequencing V4 combined with Sanger sequencing revealed mutations in FERMT1 with affected individuals. Compound heterozygous nonsense mutations (c.193C>T, c.277C>T) were found with family 1, and a homozygous frameshift mutation (c.220delC) was observed in family 2. According to the clinical features and genetic analysis, KNDLRS was diagnosed in two Chinese families. Conclusions: This study revealed two novel pathogenic mutations in FERMT1 that caused KNDLRS and briefly summarized all pathogenic mutations in FERMT1 that have been documented via the PubMed.
Development of a Prognostic Model Based on Identification of EMT-related LncRNAs in Triple Negative Breast Cancer
Authors: Guo Jiani , Yi Xuesong , Ji Zhuqing , Yao Mengchu , Yang Yu , Song Wei , Huang Mingde 
Published: March 2021

Abstract
Background: Triple negative breast cancer (TNBC) remains the most incurable subtype of breast cancer owing to high heterogeneity, aggressive nature, and lack of treatment options. It is generally acknowledged that epithelial-mesenchymal transition (EMT) is the key step in tumor metastasis. Methods: With the application of TCGA and GEO database, we identified EMT-related lncRNAs by Cox univariate regression analysis. Optimum risk scores were calculated and used to divide TNBC patients into high/low-risk subgroups by the median value using lasso regression analysis. Kaplan-Meier and ROC curve analyses were applied for model validation. Then we assessed the risk model from multi-omic aspects including immune infiltration, drug sensitivity, mutability spectrum, signaling pathways, and clinical indicators.Results: The risk model was composed of 22 EMT-related long noncoding RNAs (lncRNAs), which seemed to be valuable in prognostic prediction of TNBC patients. The model could act as an independent prognostic factor of TNBC, and showed a robust prognostic ability in the stratification analysis. Conclusions: Together, our study successfully established a risk model with great accuracy and efficacy in prognosis prediction of TNBC patients.