bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medição da versão acetabular após artroplastia total do quadril: Comparação de dois métodos radiográficos
Authors: Cardoso Afonso , Duarte Mafalda , Viegas Rui , Oliveira Filipe , Pinto Pedro , Rego Paulo 
Published: March 2021

Resumo
Objetivo O objetivo do presente trabalho foi comparar a medição da versão do componente acetabular em radiografias em incidência anteroposterior (AP) e cross-table após artroplastia total do quadril (ATQ).
Métodos Foram selecionadas radiografias de 60 quadris com ATQ primário. A versão foi calculada na radiografia AP usando o método de Lewinnek e, na cross-table, usando o método direto do Woo e Morrey.
Resultados A média e o desvio padrão (DP) foram diferentes em ambas as radiografias, sendo 9,7° ± 5,5° no AP, enquanto na cross-table foram 20,6° ± 8,4° (p < 0,001). Considerando nosso objetivo de 10°, as medidas da cross-table foram estatisticamente diferentes dele (p < 0,001), enquanto a medição AP não diferiu (p = 0,716).
Conclusão O presente estudo mostrou que a melhor maneira de avaliar corretamente o posicionamento do componente acetabular após uma ATQ é medindo a anteversão e a abdução em uma radiografia AP após confirmar, em uma radiografia cross-table, que o componente não é retrovertido.
Epidemiologia da doença de Dupuytren e de pacientes submetidos a fasciectomia seletiva
Authors: Alencar Fernando Henrique Uchôa de , Perini Jamila Alessandra , Monteiro Anderson Vieira , Duarte Maria Eugenia Leite , Motta Geraldo da Rocha , Guimarães João Antônio Matheus 
Published: March 2021

Resumo
Objetivo Descrever o perfil epidemiológico e clínico dos pacientes com doença de Dupuytren tratados por fasciectomia seletiva e os fatores associados com a gravidade da doença.
Metodologia Estudo observacional descritivo retrospectivo envolvendo 247 pacientes com doença de Dupuytren, no período de 2013 a 2019. Foi realizada regressão logística multivariada para análise dos dados.
Resultados A maioria dos pacientes era do sexo masculino (83,8%), autodeclarados brancos (65,2%), etilistas (59,6%), e 49% eram tabagistas. A média de idade foi de 66 ± 9 anos, sendo que 77,2% apresentaram os sintomas da doença após os 51 anos. Aproximadamente 51,9, 29,6, e 17,3%, respectivamente, apresentaram hipertensão arterial, diabetes mellitus e dislipidemia. O acometimento bilateral das mãos foi observado em 73,3% dos pacientes. A taxa de complicações intra- e pós-fasciectomia seletiva foi de 0,6 e 24,3%, respectivamente, sendo que 5,2% dos pacientes necessitaram de reintervenção após 1 ano de acompanhamento. Após análise multivariada, o sexo masculino foi associado com acometimento bilateral das mãos (odds ratio [OR] = 2,10; intervalo de confiança [IC] 95%: 1,03–4,31) e com maior número de raios acometidos (OR = 3,41; IC 95%: 1,66–7,03). A dislipidemia foi associada com a reintervenção (OR = 5,7; CI 95%: 1,03–31,4) e a bilateralidade com maior número de complicações (35,7% versus 19,7%).
Conclusão Foi observada uma baixa taxa de reintervenção e complicações operatórias nos pacientes com doença de Dupuytren tratados por fasciectomia seletiva. O sexo masculino foi associado com o quadro grave da doença (bilateralidade e mais de dois raios acometidos), e a dislipidemia com a reintervenção.
Artrite séptica da sínfise pubiana em adultos: Relato de caso
Authors: Labronici Pedro José , Tavares Augusto Khede , Silva Luiz Henrique Penteado , Pires Robinson Esteves Santos , Giordano Vincenzo , Loures Fabrício Bolpato 
Published: March 2021

ResumoA artrite séptica da sínfise púbica é uma condição rara. Os fatores de risco são trauma, infecção de baixo grau, procedimentos urológicos ou ginecológicos, tumores malignos da pelve, prática de esportes e uso de drogas intravenosas. O presente relato descreve um caso de artrite séptica da sínfise púbica em um paciente do sexo masculino, de 23 anos, sem história de cirurgias pélvicas, infecções prévias ou atividade física intensa. A artrite foi diagnosticada pela hemocultura que revelou crescimento de Enterococcus sp + leveduras, e o paciente foi tratado com antibioticoterapia. Este caso enfatiza a importância de exames complementares no auxílio do tratamento da artrite séptica da sínfise púbica, e demonstra que procedimentos invasivos, tais como a punção da sínfise púbica, podem não ser necessários.
Tratamento cirúrgico de fraturas osteoporóticas múltiplas da coluna dorsolombar: Relato de caso
Authors: Marques Ricardo Ramalho , Moura Diogo Lino , Lourenço Paulo 
Published: March 2021

ResumoAs fraturas vertebrais osteoporóticas são um tipo comum de fratura e afetam um número significativo da população com osteoporose. Apesar do elevado risco de fratura, a ocorrência concomitante de fraturas vertebrais em níveis não contíguos é muito rara. Reportamos o caso de uma paciente com três fraturas explosivas da coluna dorsolombar em níveis não contíguos, tratada com cifoplastia e fixação posterior transpedicular por via percutânea. Seis meses após a cirurgia, a paciente tem marcha autônoma, sem dor, e, radiologicamente, não existem evidências de perda de redução das fraturas.
The impact of Hurricanes on the value of commercial real estate
Authors: Fisher Jeffrey D. , Rutledge Sara R. 
Published: March 2021

AbstractCommercial real estate investors prefer coastal, gateway, markets for liquidity, demand density, and durable returns. Yet, these areas are more vulnerable to the effects of climate change from more intense and frequent weather events such as hurricanes and typhoons as well as to gradual changes such as sea-level rise. Recognition is growing of the risks that these events pose to investment performance, but little is known about how this risk has impacted property values and returns when an event such as a hurricane occurs. This is the first study to analyze the impact on property values and returns from hurricanes causing the most significant damage by value over the past 30-plus years throughout the nation. Using individual property data from the National Council of Real Estate Investment Fiduciaries database, we find a significant impact on the value and rates of return, after accounting for any additional capital expenditures for repairs, for properties that are in areas impacted by a hurricane, relative to areas that were not impacted by a hurricane. These impacts vary by property type and can last for several years after the hurricane hit land in the area.
Optimization design of O-ring linear accelerator gantry and mechanical isocenter detection method
Authors: Shi Chaofeng , Jiang Yanjie , Wang Xi , Chen Yifu 
Published: March 2021

With the development of the precise radiotherapy, the accuracy of radiotherapy equipment is gradually improved. The gantry, the carrier of the treatment head and various testing devices, is the most important component that determines the accuracy of the entire equipment. In this paper, the layout of the O-ring linear accelerator and the structure of the gantry are optimized to reduce the weight of the gantry by 50% and the moment of inertia by 60%. A mechanical isocenter detection method based on the laser tracker is proposed to conduct a rapid and accurate isocenter measurement for the optimized gantry. The experimental results show that the maximum deformation of the optimized gantry under load is 0.13 mm during rotation and the maximum intersection distance between the gantry axis and the treatment head axis at the isocenter position is 0.21 mm.
Design and analysis of a quasi-TM03 mode G-band extended interaction radiation source
Authors: Zu Yifan , Yuan Xuesong , Xu Xiaotao , Chen Qingyun , Cole Matthew , Yin Yong , Bi Liangjie , Li Hailong , Wang Bin , Meng Lin , Yan Yang 
Published: March 2021

A disk-loaded coupled cavity structure operating in the quasi-TM03 mode has been used here to develop a high electron efficiency, high output power terahertz radiation source, demonstrating that it is possible to concentrate the axial field energy along the source’s central axis within a large cavity. Compared with traditional extended interaction devices operating at the same frequency band, the operating mode of this present device provides a sizable beam tunnel capacity that can support efficient energy conversion between the electron beam and the high frequency field. The developed electron optical system is based on a cylindrical electron beam of 0.3 mm radius and is capable of producing a beam current of 0.65 A at a bias of 16.4 kV. Particle in cell simulations show that such new design approaches can achieve kilowatt-level output power at 0.22 THz with a high electron efficiency of 11.5%.
Titanium dioxide nanotubes: synthesis, structure, properties and applications
Authors: Rempel Andrey A. , Valeeva Albina A. , Vokhmintsev Alexander S. , Weinstein Ilya A. 
Published: March 2021

AbstractMethods of synthesis of nanotubular structures based on titania of various phase and chemical compositions are described. A systematic account is given of known data about the influence of synthesis and subsequent treatment conditions on the amorphous and crystal structures, specific surface area, morphology and optical, luminescence and electro-physical properties of titania-based nanotubular oxide materials. The photocatalytic properties in the oxidation reactions of organic compounds and the performance characteristics of the memristive behaviour of TiO2-based nanotubular structures are considered in details. Their applications are discussed.The bibliography includes 238 references.
A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer
Authors: Xu Lingfan , Yin Yu , Li Yanjing , Chen Xufeng , Chang Yan , Zhang Hong , Liu Juan , Beasley James , McCaw Patricia , Zhang Haoyue , Young Sarah , Groth Jeff , Wang Qianben , Locasale Jason W. , Gao Xia , Tang Dean G. , Dong Xuesen , He Yiping , George Daniel , Hu Hailiang , Huang Jiaoti 
Published: March 2021

Significance
We report that androgen receptor (AR) promotes glutaminase 1 (GLS1) expression and glutamine utilization to support the survival of prostate cancer (PCa) cells. Hormonal therapy inhibits AR and decreases GLS1 expression and glutamine utilization to achieve therapeutic effect. Our results suggest that eventually the tumor cells switch GLS1 expression from the AR-dependent KGA isoform to the androgen-independent and enzymatically more potent GAC isoform, which increases glutamine utilization and can contribute to the development of castration-resistant PCa. Our work has discovered a previously unknown AR function, a metabolic mechanism of hormonal therapy and an important therapeutic target more specific than AR. Targeting GLS1 may achieve similar therapeutic efficacy but without the side effects resulting from inhibiting AR’s other important physiologic functions.
A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment
Authors: Song Jen-Shin , Chang Chih-Chun , Wu Chien-Huang , Dinh Trinh Kieu , Jan Jiing-Jyh , Huang Kuan-Wei , Chou Ming-Chen , Shiue Ting-Yun , Yeh Kai-Chia , Ke Yi-Yu , Yeh Teng-Kuang , Ta Yen-Nhi Ngoc , Lee Chia-Jui , Huang Jing-Kai , Sung Yun-Chieh , Shia Kak-Shan , Chen Yunching 
Published: March 2021

Significance
A highly selective, safe, and potent CXCR4 antagonist, BPRCX807, has been designed and experimentally validated in various hepatocellular carcinoma models. Through combination therapy, it can synergize with either a kinase (e.g., sorafenib) or checkpoint inhibitor (e.g. anti–PD-1) to augment effectiveness of current anticancer treatments. With its unique mode of action, a new anticancer strategy for preventing cell migration and metastasis is provided.
Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells
Authors: Shim Myoung Sup , Nettesheim April , Dixon Angela , Liton Paloma B. 
Published: March 2021

Significance
The trabecular meshwork is the major tissue regulating intraocular pressure (IOP). Malfunction of this tissue results in ocular hypertension, the major risk factor for glaucoma. How IOP is regulated is still unknown, but it is accepted that mechanosensation and mechanotransduction are critical regulators. In this study, we report that primary cilia (PC) is a mechanosensor for stretch-induced autophagy in TM cells and identified a reciprocal activation of AKT1 and SMAD2/3 as a signaling pathway regulating the activation of autophagy by PC. Most importantly, we showed that PC-mediated autophagy plays a critical role in IOP homeostasis. These findings tremendously contribute to our understanding of TM biology and identify new potential targets for therapeutic strategies.
Shape anisotropy-governed locomotion of surface microrollers on vessel-like microtopographies against physiological flows
Authors: Bozuyuk Ugur , Alapan Yunus , Aghakhani Amirreza , Yunusa Muhammad , Sitti Metin 
Published: March 2021

Significance
Controlled microrobotic navigation in blood vessels holds significant potential to revolutionize targeted drug delivery. Navigation on the surface of the blood vessels is advantageous because of decreased flow velocities; however, surface microtopography of blood vessels, in the size scale of the microrobots, is a major hurdle for robust locomotion of surface-rolling microrobots against the blood flow. Here, we show the effect of the body-shape anisotropy of the microrollers on their locomotion capability over vessel-like microtopographies. We demonstrate by experiments and simulations that the microrollers with slender bodies are more robust to locomote on biological microtopographies due to their favorable hydrodynamic interactions. Thus, such anisotropically shaped microrollers would be more viable and robust in future in vivo medical applications.
The number of catalytic cycles in an enzyme’s lifetime and why it matters to metabolic engineering
Authors: Hanson Andrew D. , McCarty Donald R. , Henry Christopher S. , Xian Xiaochen , Joshi Jaya , Patterson Jenelle A. , García-García Jorge D. , Fleischmann Scott D. , Tivendale Nathan D. , Millar A. Harvey 
Published: March 2021

Significance
The continuous replacement of enzymes and other proteins appropriates up to half the maintenance energy budget in microorganisms and plants. High enzyme replacement rates therefore cut the productivity of biosystems ranging from microbial fermentations to crops. However, yardsticks to assess what drives enzyme protein replacement and guidelines on how to reduce it are lacking. Accordingly, we compared enzymes’ life spans across kingdoms using a new yardstick (catalytic cycles until replacement [CCR]) and related CCR to enzyme reaction chemistry. We concluded that 1) many enzymes fail due to collateral damage from the reaction they catalyze, and 2) such damage and its attendant enzyme replacement costs are mitigable by engineering and are therefore promising targets for synthetic biology.
Multiple migrations to the Philippines during the last 50,000 years
Authors: Larena Maximilian , Sanchez-Quinto Federico , Sjödin Per , McKenna James , Ebeo Carlo , Reyes Rebecca , Casel Ophelia , Huang Jin-Yuan , Hagada Kim Pullupul , Guilay Dennis , Reyes Jennelyn , Allian Fatima Pir , Mori Virgilio , Azarcon Lahaina Sue , Manera Alma , Terando Celito , Jamero Lucio , Sireg Gauden , Manginsay-Tremedal Renefe , Labos Maria Shiela , Vilar Richard Dian , Latiph Acram , Saway Rodelio Linsahay , Marte Erwin , Magbanua Pablito , Morales Amor , Java Ismael , Reveche Rudy , Barrios Becky , Burton Erlinda , Salon Jesus Christopher , Kels Ma. Junaliah Tuazon , Albano Adrian , Cruz-Angeles Rose Beatrix , Molanida Edison , Granehäll Lena , Vicente Mário , Edlund Hanna , Loo Jun-Hun , Trejaut Jean , Ho Simon Y. W. , Reid Lawrence , Malmström Helena , Schlebusch Carina , Lambeck Kurt , Endicott Phillip , Jakobsson Mattias 
Published: March 2021

SignificanceA key link to understand human history in Island Southeast Asia is the Philippine archipelago and its poorly investigated genetic diversity. We analyzed the most comprehensive set of population-genomic data for the Philippines: 1,028 individuals covering 115 indigenous communities. We demonstrate that the Philippines were populated by at least five waves of human migration. The Cordillerans migrated into the Philippines prior to the arrival of rice agriculture, where some remain as the least admixed East Asians carrying an ancestry shared by all Austronesian-speaking populations, thereby challenging an exclusive out-of-Taiwan model of joint farming–language–people dispersal. Altogether, our findings portray the Philippines as a crucial gateway, with a multilayered history, that ultimately changed the genetic landscape of the Asia-Pacific region.
Syntactic parallelism and the co-production of syntactic units in Mandarin Chinese
Authors: Gao Yanmei , Ren Xiaohua 
Published: March 2021

AbstractCross-linguistic studies on co-production of syntactic units and compound sentence formats have found that the location of predicates affects the projectability of the language, in that languages like English allow early projections while languages like Japanese later projections. In Mandarin Chinese, we found that syntactic parallelism often occurs before co-constructions, impacting the projectability of syntactic structures in one way or another. Based on the theories of dialogic syntax (Du Bois 2007,2014) and the principles of interactional linguistics, this study explores the relationship between syntactic parallelism and co-production of syntactic structures across turns. The co-production of four syntactic and sentential structures were closely examined, namely,Copula V+Complement, (be) Adjectival Predicate, the conditionalIF X THEN Yconstruction(如果ruguo……就/会jiu/hui……), and compound sentences withto-clause of purpose. Also observed is the emergent new sequence as interactionally relevant syntax. Upon inspection, we found that turn units with parallel syntactic structures may help narrow down the category of the projected final component, thus inspiring the second speaker to come in early and jointly complete the syntax-in-progress. Apart from co-producing syntax-in-progress, co-produced structures can also develop into interactionally relevant sequences with independent internal structures, thereby executing new social actions.
How do Public Libraries Respond to Patron Queries about Opioid use Disorder? A Secret Shopper Study
Authors: Wong Vivien , Cannuscio Carolyn C. , Lowenstein Margaret , Feuerstein-Simon Rachel , Graves Rachel , Meisel Zachary F. 
Published: March 2021

Background Improving linkage to opioid use disorder (OUD) treatment and services is a public health priority. Public libraries, a community resource for health information, may be well positioned to support and guide people who use drugs, as well as their families and friends. In this study, we sought to evaluate the availability and types of resources offered to patrons inquiring about OUD information, OUD treatment, and naloxone access. Methods We conducted an audit (secret shopper) study from April 2019 to June 2019 in which an auditor anonymously called Pennsylvania public libraries. We used a purposive sampling strategy to select libraries located in geographically diverse regions across the urban-rural continuum. We categorized responses and verified via phone or website whether referrals to treatment centers and other organizations provided OUD treatment or services. Results We obtained responses from 100 public libraries located across 48 of the 67 counties in Pennsylvania. Among the libraries that responded, 57 provided health information resources (e.g., books, websites) and 82 provided “next step” referrals to an organization that could provide further assistance. Among the libraries that provided referrals, 39 were to treatment centers, of which 33 were specifically to treatment centers that offer medications for OUD. Of the responding libraries, 28 communicated information about naloxone access. Conclusion Public libraries can and do connect patrons to OUD treatment and support services; however, there is wide interlibrary variation in the resources presented, demonstrating opportunities for improvement in how libraries engage and refer patrons with substance use needs.
Trust in Research Physicians as a Key Dimension of Randomized Controlled Trial Participation in Clinical Addictions Research
Authors: Jaffe Kaitlyn , Nosova Ekaterina , DeBeck Kora , Hayashi Kanna , Milloy M.-J. , Richardson Lindsey 
Published: March 2021

Background In the development of pharmacotherapies for substance use disorders, willingness to participate in randomized controlled trials (RCTs) among people who use drugs (PWUD) is influenced by numerous social and structural factors. Considering the criminalization and stigma experienced by PWUD and range of experiences in healthcare and research, PWUD may vary in their trust of health providers, health research physicians, or medical research processes. We therefore examine associations between trust in these three domains and willingness to participate in a hypothetical RCT for a novel pharmacotherapy for stimulant use among PWUD. Methods Data were derived from a cross-sectional questionnaire administered to participants using crack and/or cocaine from three cohort studies of PWUD in Vancouver ( N = 229). Results A majority of participants were “definitely” or “probably” willing to participate in an RCT. In multivariable ordinal regression, trust in research physicians was positively associated with willingness to participate, while trust in primary care providers or medical research processes were not significantly associated. Conclusions This data suggests trust in research physicians plays a role in RCT decision-making among PWUD, while trust in healthcare providers and research processes appears less relevant. These findings highlight opportunities for supporting RCT recruitment by building trust in research physicians.