bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of response to etanercept-methotrexate treatment: a post hoc logistic regression analysis of a randomized, open-label study in Latin American patients with rheumatoid arthritis
Authors: de la Vega Maria , Guerra Bautista Generoso , Xavier Ricardo Machado , Pacheco-Tena César , Solano Gastón , Pedersen Ronald D. , Szumski Annette Eva , Borlenghi Cecilia , Santana Karina , Vlahos Bonnie 
Published: September 2021

AbstractBackgroundDetermining potential predictors of clinical response would allow a more personalized rheumatoid arthritis (RA) treatment approach in heterogeneous populations such as Latin American (LA) patients.MethodsPost hoc analysis to identify baseline characteristics predictive of clinical remission in response to treatment with etanercept (ETN) plus methotrexate (MTX) in LA patients with moderate to severe MTX-resistant RA. We report data from the group of patients who received ETN 50 mg/week plus MTX (ETN + MTX,n = 281) in a clinical trial consisting of an initial 24-week open-label phase, followed by a 104-week extension. Remission was defined as 28-joint Disease Activity Score with erythrocyte sedimentation rate (DAS28-ESR) score < 2.6. Cutoff values to dichotomize baseline variables maximizing the detection of remission were obtained from Receiver Operator Curve analyses. Baseline dichotomized and categorical variables were analyzed altogether in a stepwise logistic regression model. Odds of attaining response at Weeks 24 and 128 were estimated for each significant predictor.ResultsAt Week 24 and Week 128, 27% (66/241) and 42% (91/219) of patients in the ETN + MTX group achieved remission. On average, patients achieving remission were younger and had lower baseline ESR, lower Physician Global Assessment (PGA) scores, lower total Health Assessment Questionnaire (HAQ) scores, and lower visual analog scale (VAS) Pain scores compared with patients who did not achieve remission. The best subset of baseline variables predicting Week 24 remission in the stepwise regression model were age ≤ 49 years (odds ratio [OR] 2.93), body mass index (BMI) > 28.5 kg/m2(OR 3.24), disease duration > 3.7 years (OR 2.22), ESR ≤ 42 mm/h (OR 2.72), PGA ≤ 6 (OR 3.21), tender joint count ≤ 14 (OR 2.25), and total HAQ score ≤ 1.6 (OR 2.86). At Week 128, age ≤ 42 years (OR 2.21), SF-36 Mental Health Scale score > 39.6 (OR 2.16), White race (OR 4.07), > 18 swollen joints (OR 2.11), and VAS Pain ≤ 41 (OR 6.05) at baseline were the best subset of significant predictors of remission.ConclusionsIn LA patients with RA, younger age, higher BMI, longer disease duration, higher SF-36 Mental Health Scale score, higher swollen joint count, and overall lower disease activity predicted clinical response to ETN + MTX therapy.Trial registration: ClinicalTrials.gov Identifier: NCT00848354.
Transgenic fluorescent zebrafish lines that have revolutionized biomedical research
Authors: Choe Chong Pyo , Choi Seok-Yong , Kee Yun , Kim Min Jung , Kim Seok-Hyung , Lee Yoonsung , Park Hae-Chul , Ro Hyunju 
Published: September 2021

AbstractSince its debut in the biomedical research fields in 1981, zebrafish have been used as a vertebrate model organism in more than 40,000 biomedical research studies. Especially useful are zebrafish lines expressing fluorescent proteins in a molecule, intracellular organelle, cell or tissue specific manner because they allow the visualization and tracking of molecules, intracellular organelles, cells or tissues of interest in real time and in vivo. In this review, we summarize representative transgenic fluorescent zebrafish lines that have revolutionized biomedical research on signal transduction, the craniofacial skeletal system, the hematopoietic system, the nervous system, the urogenital system, the digestive system and intracellular organelles.
No difference in long-term functional outcomes or survivorship after total knee arthroplasty with or without computer navigation: a 17-year survivorship analysis
Authors: Patrick Ng Jonathan , Man Lau Lawrence Chun , Wai-Wang Chau , Tim-Yun Ong Michael , Wing Cheung Kin , Hing Chiu Kwok , Yin Chung Kwong , Ki-Wai Ho Kevin 
Published: September 2021

AbstractBackgroundThe literature comparing the long-term outcomes and survivorship of computer navigation-assisted and conventional total knee replacement (TKR) is sparse. Moreover, of the available comparative studies with follow-up duration of more than 10 years, the results seem to be conflicting. The purpose of this long-term study was to compare the clinical and radiological outcomes, and implant survivorship, of TKR performed with and without computer navigation.MethodsWe retrospectively compared the results of 49 computer-navigated TKRs and 139 conventional TKRs. The mean age of the patients was 67.9 (range 52–81) years for the navigation group and 67.1 (range 50–80) years for the conventional TKR group. The mean duration of follow-up for the conventional and navigation TKR groups was 12.9 and 13.2 years, respectively. Clinical and radiographic follow-up examinations of the patients were performed at 2 weeks, 1 month, 3 months and 6 months post-operatively, and at 1-year intervals thereafter.ResultsThere were no significant differences in the post-operative Knee Society knee and function score between the two groups. The mean overall deviation from neutral alignment and the radiological outliers were significantly higher in the conventional TKR group. The overall survival rates at 17 years were 92.9% for the navigation group and 95.6% for the conventional TKR group (p = 0.62).ConclusionsNavigated TKR resulted in fewer radiological outliers; however, this did not translate to better long-term functional outcomes or implant survival.
Do “Myths” of low back pain exist among young Indian college-going adults with a history of low back pain? A cross-sectional study
Authors: Suhail Ammar , Slathia Sonal , Quais Sarah , Poulter David C. 
Published: September 2021

AbstractBackgroundLow back pain (LBP) is a prominent public health problem which causes disability around the globe. The prevalence of LBP is on the rise in lower to middle-income countries. India has a varied prevalence of LBP among the rural as well as urban population ranging from 6.2 to 92%. There has been a marked increase in young adults getting LBP with a proportion converting to chronic LBP later in life. Beliefs associated with any disorder affect the course, management, and need for imaging studies. Negative beliefs about LBP in any population may lead to unnecessary psychologic distress and an increase in disease burden. Focusing these negative beliefs on the younger population can help curb the chronicity and lessen the disability caused by it. This cross-sectional study explored the presence of myths in 516 college-going Indian young adults from Lovely Professional University.ResultsA total of 516 individuals participated in the study. The mean (SD) age of the participants was 22.69 years (2.417). Among them, 47.5% (245) were females and 52.5% (271) were males. The findings show that a high percentage of college-going young adults have false beliefs in most of the ten domains (myths) explored. The most prevalent myths were “LBP is caused by weak ‘core’ muscles and having a strong core protects against future LBP” (81.2%) and “LBP is caused by poor posture when sitting, standing, and lifting” with 80.6% agreeing to it.ConclusionOur study demonstrated that the myths of low back pain are widespread among the studied population. The findings suggest that community education programs must be developed to address these myths, hence reducing the disease burden associated with back pain.
Improving the data access control using blockchain for healthcare domain
Authors: Tahir Yinka Olaosebikan , Haw Su-Cheng , Yap Timothy Tzen Vun , Subramaniam Samini 
Published: September 2021

Introduction Unauthorized access to data is one of the most significant privacy issues that hinder most industries from adopting big data technologies. Even though specific processes and structures have been put in place to deal with access authorization and identity management for large databases nonetheless, the scalability criteria are far beyond the capabilities of traditional databases. Hence, most researchers are looking into other solutions, such as big data management. Methods In this paper, we firstly study the strengths and weaknesses of implementing cryptography and blockchain for identity management and authorization control in big data, focusing on the healthcare domain. Subsequently, we propose a decentralized data access and sharing system that preserves privacy to ensure adequate data access management under the blockchain. In addition, we designed a blockchain framework to resolve the decentralized data access and sharing system privacy issues, by implementing a public key infrastructure model, which utilizes a signature cryptography algorithm (elliptic curve and signcryption). Lastly, we compared the proposed blockchain model to previous techniques to see how well it performed. Results We evaluated the blockchain on four performance metrics which include throughput, latency, scalability, and security. The proposed blockchain model was tested using a sample of 5000 patients and 500,000 observations. The performance evaluation results further showed that the proposed model achieves higher throughput and lower latency compared to existing approaches when the workload varies up to 10,000 transactions. Discussion This research reviews the importance of blockchains as they provide infinite possibilities to individuals, companies, and governments.
Ultracompact and broadband silicon-based polarization-independent 1 × 2 power splitter using a shallowly etched multimode interference coupler
Authors: Chen Yufei , Xiao Jinbiao 
Published: September 2021

An ultracompact and broadband silicon-based polarization-independent power splitter is proposed by utilizing a multimode waveguide with a shallowly etched tapered slot. For input TM mode, it is divided into two beams via adiabatic mode evolution, since it cannot be well supported in the etched region, analogous to a Y-branch, and then propagates through two output channels. As to the input TE mode, unaffected by the shallowly etched slot, a twofold image is formed via self-imaging effect, corresponding to a normal multimode interference coupler, and then equally divided into two output channels. As a result, power splitting for both polarizations is realized simultaneously. Results show that there is an insertion loss of

<

0.4

d
B

(0.2 dB) and a reflection loss of

<

−

25

d
B

(

−

35

d
B

) for the TE (TM) polarization over the broad wavelength range of 1310 to 1870 nm, while having a device length of only 5.8 µm. Additionally, fabrication tolerances to the key structural parameters are studied in detail, and field evolution through the proposed device for both polarizations is illustrated.
Femtosecond laser inscribed helical sapphire fiber Bragg gratings
Authors: Guo Qi , Liu Shanren , Pan Xuepeng , Wang Bo , Tian Zhennan , Chen Chao , Chen Qidai , Yu Yongsen , Sun Hongbo 
Published: September 2021

This Letter reports a novel helical sapphire fiber Bragg grating (HSFBG) in a single crystal sapphire fiber with diameter of 60 µm fabricated by a 515 nm femtosecond laser. Due to the large refractive index modulation region and high structural symmetry of the HSFBGs, high-reflectivity and high-quality spectra can be prepared and additionally have good bending resistance. The spectral properties of HSFBGs with different helical diameters are studied. When the helical diameter is 30 µm, the reflectivity of HSFBG is 40%, the full width at half-maximum is 1.56 nm, and the signal-to-noise ratio is 16 dB. For the HSFBG bending test, the minimum bending radius is 5 mm, which can still maintain relatively good spectral quality. In addition, the HSFBG array with different periods has been successfully cascaded in a sapphire fiber. The experimental results of the HSFBG high-temperature test show that this HSFBG can work reliably at 1600°C, and the temperature sensitivity in the high-temperature range can reach 35.55 pm/°C. This HSFBG can be used in high-temperature and harsh environments, such as metal smelting and aeroengine structural health monitoring.
Towards a space-qualified Kerr-lens mode-locked laser
Authors: Feng Ye , Lamour Tobias P. , Ostapenko Hanna , McCracken Richard A. , Mandel Oliver , Weise Dennis , Reid Derryck T. 
Published: September 2021

We report a 1.5-GHz Kerr-lens mode-locked (KLM) Yb:

Y

2

O

3

ring laser constructed by directly bonding the cavity components onto an aluminum baseplate. Stable unidirectional operation with an output power

≥

10

m
W

was obtained for pump-diode currents of 300–500 mA, corresponding to a total electrical power consumption of 1.5 W. After repetition rate stabilization, a comparison with a conventionally constructed identical laser showed a 50% reduction in phase noise. In free-running operation the bonded laser showed superior passive repetition rate stability. The bonding process follows an already proven integration approach in space-borne instrumentation, mapping a development pathway for KLM lasers in aerospace applications.
Dynamics of G6PD activity in patients receiving weekly primaquine for therapy of Plasmodium vivax malaria
Authors: Taylor Walter R. J. , Kim Saorin , Kheng Sim , Muth Sinoun , Tor Pety , Christophel Eva , Mukaka Mavuto , Kerleguer Alexandra , Luzzatto Lucio , Baird J. Kevin , Menard Didier 
Published: September 2021

Background
Acute Plasmodium vivax malaria is associated with haemolysis, bone marrow suppression, reticulocytopenia, and post-treatment reticulocytosis leading to haemoglobin recovery. Little is known how malaria affects glucose-6-phosphate dehydrogenase (G6PD) activity and whether changes in activity when patients present may lead qualitative tests, like the fluorescent spot test (FST), to misdiagnose G6PD deficient (G6PDd) patients as G6PD normal (G6PDn). Giving primaquine or tafenoquine to such patients could result in severe haemolysis.

Methods
We investigated the G6PD genotype, G6PD enzyme activity over time and the baseline FST phenotype in Cambodians with acute P. vivax malaria treated with 3-day dihydroartemisinin piperaquine and weekly primaquine, 0·75 mg/kg x8 doses.

Results
Of 75 recruited patients (males 63), aged 5–63 years (median 24), 15 were G6PDd males (14 Viangchan, 1 Canton), 3 were G6PD Viangchan heterozygous females, and 57 were G6PDn; 6 patients had α/β-thalassaemia and 26 had HbE.
Median (range) Day0 G6PD activities were 0·85 U/g Hb (0·10–1·36) and 11·4 U/g Hb (6·67–16·78) in G6PDd and G6PDn patients, respectively, rising significantly to 1·45 (0·36–5·54, p<0.01) and 12·0 (8·1–17·4, p = 0.04) U/g Hb on Day7, then falling to ~Day0 values by Day56. Day0 G6PD activity did not correlate (p = 0.28) with the Day0 reticulocyte counts but both correlated over time. The FST diagnosed correctly 17/18 G6PDd patients, misclassifying one heterozygous female as G6PDn.

Conclusions
In Cambodia, acute P. vivax malaria did not elevate G6PD activities in our small sample of G6PDd patients to levels that would result in a false normal qualitative test. Low G6PDd enzyme activity at disease presentation increases upon parasite clearance, parallel to reticulocytosis. More work is needed in G6PDd heterozygous females to ascertain the effect of P. vivax on their G6PD activities.

Trial registration
The trial was registered (ACTRN12613000003774) with the Australia New Zealand Clinical trials (https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=363399&isReview=true).
Covid-19: were curfews in France associated with hospitalisations?
Authors: Le Bourg Eric 
Published: September 2021

Abstract

Objectives
A curfew was introduced in France in October 2020 to reduce the spread of Covid-19. This was done for two weeks in 16 departments, or for one week in 38 others, 42 departments not being subjected to the curfew. This article compares the number of new daily hospital admissions in these departments.

Methods
The ratio of the number of new hospitalisations during these two weeks and in the previous two weeks was computed in the three categories of departments.

Results
The increase in new hospitalisations was lower in departments under curfew for two weeks than in all other departments, and this result does not seem to be linked to characteristics of the departments before curfew.

Conclusions
This result shows that the two-week curfew is linked to a lower increase of hospitalisations, but not that the curfew by itself is the cause of this result, as other factors may have played a role.
Stable super-hydrophobic and comfort PDMS-coated polyester fabric
Authors: Xu Liyun , Xie Kaifang , Liu Yuegang , Zhang Chengjiao 
Published: September 2021

Abstract
Super-hydrophobic fabrics have shown great potential during the last decade owing to their novel functions and enormous potential for diver’s applications. Surface textures and low surface energy coatings are the keys to high water repellency. However, the toxicity of nanomaterials, long perfluorinated side-chain polymers, and the fragile of micro/nano-texture lead to the super-hydrophobic surfaces are confined to small-scale uses. Thus, in this article, a stable polydimethylsiloxane (PDMS)-coated super-hydrophobic poly(ethylene terephthalate) (PET) fabric (PDMS-g-PET) is manufactured via dip-plasma crosslinking without changing the wearing comfort. Benefiting from the special wrinkled structure of PDMS film, the coating is durable enough against physical abrasion and repeated washing damage, which is suffered from 100 cycles of washing or 500 abrasion cycles, and the water contact angle is still above 150°. This study promotes the way for the development of environmentally friendly, safe, and cost-efficient for designing durable superhydrophobic coatings for various practical applications.
Social Entrepreneurship and Volunteering: Moderation Effects of Volunteer Experience Levels on Social Entrepreneurial Intent Model
Authors: Ghazali Ezlika M , Mutum Dilip S , Nguyen Bang , Hamzah Zalfa Laili , Mohtar Mozard 
Published: September 2021

Abstract
This study investigates whether an individual’s social work experience impacts the relationship between institutional environmental constructs and the perceived desirability and feasibility of establishing a social venture. It extends Urban, B. and L. Kujinga’s. (2017. “The Institutional Environment and Social Entrepreneurship Intentions.” International Journal of Entrepreneurial Behaviour and Research 23 (4): 638–55, doi: 10.1108/IJEBR-07-2016-0218.) social entrepreneurial intent model by comparing two groups of volunteers in Malaysia with different levels of social working or volunteering experience. The results show that the cognitive environment influences perceived desirability, with a distinctly higher path significance for perceived desirability among individuals with higher levels of experience. Perceived desirability has a relatively more substantial impact on social entrepreneurship intention for highly experienced individuals. Interestingly, the results indicate that neither the regulatory nor the normative environment influences perceived feasibility for either group. Governments and other relevant organisations can utilise these findings to devise better policies for promoting social entrepreneurship.
Role of magnetic resonance diffusion weighted imaging in diagnosis of diabetic nephropathy in children living with type 1 diabetes mellitus
Authors: Wahba Eman Nabil , Elsharkawy Ashraf , Awad Mohammad Hosny , Abdel Rahman Ashraf , Sarhan Amr 
Published: September 2021

Abstract

Objectives
Diabetic nephropathy is a serious and a common complication of diabetes that can lead to end stage renal disease among children living with type 1 diabetes, thus an early and accurate method of diagnosis that allows timely intervention is of high importance. This study aimed to evaluate the role of magnetic resonance diffusion weighted imaging in diagnosis of diabetic nephropathy in children with type 1 diabetes.

Methods
This prospective, observational, case control study included 30 children with type 1 diabetes and 30 matched healthy controls attending the outpatient clinics in Mansoura University Children’s Hospital. All were subjected to magnetic resonance DWI of the renal parenchyma and their glomerular filtration rate (GFR) was estimated, along with micro albumin in 24 h urine collection and HbA1c in patients with diabetes.

Results
Children with diabetes who were positive for microalbuminuria had significantly lower apparent diffusion coefficient value compared to Children with diabetes who were negative for microalbuminuria (p = 0.034) as well as controls (p = 0.001). Among children with type 1 diabetes, apparent diffusion coefficient had significant positive correlation with estimated glomerular filtration rate (r = 0.491, p = 0.006) and negative correlation with microalbuminuria (r = −0.437, p = 0.016).

Conclusion
Magnetic resonance DWI of the renal parenchyma is correlated with estimated glomerular filtration rate (eGFR) in children with type 1 diabetes and can detect GFR deterioration even in presence of normal albumin excretion.
Поверхнева енергія та структура зародків при кристалізації дигідрату сульфату кальцію з водних розчинів
Authors: Gayevskii V.R. , Kochmarskii V.Z. , Gayevska S.G. 
Published: September 2021

Дослiджувалась кристалiзацiя CaSO4 · 2H2O при змiнi концентрацiї iонiв Ca2+ i постiйнiй концентрацiї SO2−4. Встановлено, що концентрацiя комплексiв CaSO04 може перевищувати концентрацiю iонiв Ca2+, що впливає на умови кристалiзацiї, зокрема, на перенасичення. За даними вимiрювань iндукцiйного перiоду визначено поверхневу енергiю зародкiв i встановлено, що вона змiнюється в межах 6,4–10,8 мДж/м2 залежно вiд спiввiдношення мiж концентрацiями iонiв кальцiю i комплексiв CaSO04. Вважаємо, що величина поверхневої енергiї залежить вiд умов формування протозародкiв. Приймаємо, що протозародками є мiцели, ядра яких при переходi вiд CCa2+ < CSO2−4 до CCa2+ > CCaSO04 > CSO2−4 зазнають перезарядки.
Про участь вчених НАН України в протидії COVID-19. Створення вакцин проти SARS-CoV-2 та COVID-19 в Україні: стан, проблеми та перспективи
Authors: Комісаренко Сергій Васильович 
Published: September 2021

У доповіді зазначено, що в установах НАН України, зокрема в Інституті біохімії ім. О.В. Палладіна НАН України, Інституті біології клітини НАН України, Інституті молекулярної біології і генетики HAH України, Інституті мікробіології і вірусології ім. Д.К. Заболотного НАН України, активно ведуться роботи з розроблення прототипів вітчизняних РНК- та субодиничних вакцин проти коронавірусу SARS-CoV-2, який викликає небезпечне вірусне захворювання COVID-19.