bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computer Modeling of Radiofrequency Cardiac Ablation including Heartbeat-Induced Electrode Displacement
Authors: Pérez Juan J. , González-Suárez Ana , Nadal Enrique , Berjano Enrique 
Published: December 2021

AbstractBackgroundThe state of the art in computer modeling of radiofrequency catheter ablation (RFCA) only considers a static model, i.e. it does not allow modeling ablation electrode displacements induced by tissue movement due to heartbeats. This feature is theoretically required, since heartbeat-induced changes in contact force can be detected during this clinical procedure.MethodsWe built a 2D RFCA model coupling electrical, thermal and mechanical problems and simulated a standard energy setting (25 W – 30 s). The mechanical interaction between the ablation electrode and tissue was dynamically modeled to reproduce heartbeat-induced changes in the electrode insertion depth from 0.86 to 2.05 mm, which corresponded with contact forces between 10 and 30 g when cardiac tissue was modeled by a hyperelastic Neo-Hookean model with a Young’s modulus of 75 kPa and Poisson’s ratio of 0.49.ResultsThe dynamic model computed a lesion depth of 5.86 mm, which is within the range of previous experimental results based on a beating heart for a similar energy setting and contact force (5.6−6.7 mm). Lesion size was practically identical (differences less than 0.02 mm) to that using a static model with the electrode inserted to an average depth (1.46 mm, equivalent to 20 g contact force).ConclusionsThe RFCA dynamic model including heartbeat-induced electrode displacement predicts lesion depth reasonably well compared to previous experimental results based on a beating heart model, however this is true only at a standard energy setting and moderate contact force.
Microtubule-associated IQD9 guides cellulose synthase velocity to shape seed mucilage
Authors: Yang Bo , Stamm Gina , Bürstenbinder Katharina , Voiniciuc Cătălin 
Published: December 2021

SummaryArabidopsis seeds release large capsules of mucilaginous polysaccharides, which are shaped by an intricate network of cellulosic microfibrils. Cellulose synthase complexes is guided by the microtubule cytoskeleton, but it is unclear which proteins mediate this process in the seed coat epidermis (SCE).Using reverse genetics, we identified IQ67 DOMAIN 9 (IQD9) and KINESIN LIGHT CHAIN-RELATED 1 (KLCR1) as two highly expressed genes during seed development and comprehensively characterized their roles for cell wall polysaccharide biosynthesis and cortical microtubule (MT) organization.Mutations in IQD9 as well as in KLCR1 lead to compact mucilage capsules with aberrant cellulose distribution, which can be rescued by transgene complementation. Double mutant analyses revealed that their closest paralogs (IQD10 and KLCR2, respectively) are not required for mucilage biosynthesis. IQD9 physically interacts with KLCR1 and localizes to cortical MTs to maintain their organization in SCE cells. Similar to the previously identified TONNEAU1 (TON1) RECRUITING MOTIF 4 (TRM4) protein, IQD9 is required to maintain the velocity of cellulose synthases.Our results demonstrate that IQD9, KLCR1 and TRM4 are MT-associated proteins that are required for seed mucilage architecture. This study provides the first direct evidence that members of the IQD, KLCR and TRM families have overlapping roles in guiding the distribution of cell wall polysaccharides. Therefore, SCE cells provide an attractive system to further decipher the complex genetic regulation of polarized cellulose deposition.
Regulation of mitochondrial proteostasis by the proton gradient
Authors: Patron Maria , Tarasenko Daryna , Nolte Hendrik , Ghosh Mausumi , Ohba Yohsuke , Lasarzewski Yvonne , Ahmadi Zeinab Alsadat , Cabrera-Orefice Alfredo , Eyiama Akinori , Kellermann Tim , Rugarli Elena I. , Brandt Ulrich , Meinecke Michael , Langer Thomas 
Published: December 2021

SummaryMitochondria adapt to different energetic demands reshaping their proteome. Mitochondrial proteases are emerging as key regulators of these adaptive processes. Here, we use a multi-proteomic approach to demonstrate regulation of the m-AAA protease AFG3L2 by the mitochondrial proton gradient, coupling mitochondrial protein turnover to the energetic status of mitochondria. We identify TMBIM5 (previously also known as GHITM or MICS1) as a Ca2+/H+ exchanger in the mitochondrial inner membrane, which binds to and inhibits the m-AAA protease. TMBIM5 ensures cell survival and respiration, allowing Ca2+ efflux from mitochondria and limiting mitochondrial hyperpolarization. Persistent hyperpolarization, however, triggers degradation of TMBIM5 and activation of the m-AAA protease. The m-AAA protease broadly remodels the mitochondrial proteome and mediates the proteolytic breakdown of respiratory complex I to confine ROS production and oxidative damage in hyperpolarized mitochondria. TMBIM5 thus integrates mitochondrial Ca2+ signaling and the energetic status of mitochondria with protein turnover rates to reshape the mitochondrial proteome and adjust the cellular metabolism.
Glycine targets NINJ1-mediated plasma membrane rupture to provide cytoprotection
Authors: Borges Jazlyn P. , Sætra Ragnhild S. R. , Volchuk Allen , Bugge Marit , Kilburn Bridget , Goldenberg Neil M. , Flo Trude H. , Steinberg Benjamin E. 
Published: December 2021

AbstractFirst recognized 35 years ago, glycine is known to protect cells against plasma membrane rupture from diverse types of tissue injury. This robust and widely observed effect has been speculated to target a late downstream process common to multiple modes of tissue injury. The molecular target of glycine cytoprotection, however, remains entirely elusive. We hypothesized that glycine targets ninjurin-1 (NINJ1), a newly identified executioner of plasma membrane rupture in pyroptosis, necrosis, and post-apoptotic cell death. NINJ1 is thought to cluster within the plasma membrane to cause cell rupture. Here, we first demonstrate that NINJ1 knockout functionally and morphologically phenocopies glycine cytoprotection in mouse and human macrophages stimulated to undergo lytic cell death. Next, we show that glycine treatment prevents NINJ1 clustering thereby preserving cellular integrity. By identifying NINJ1 as a glycine target, our data help resolve a long-standing mechanism of glycine cytoprotection. This new understanding will inform the development of cell preservation strategies to counter pathologic lytic cell death pathways.Graphical abstractSummaryGlycine is known to protect cells against plasma membrane rupture from diverse types of tissue injury by an unknown mechanism. The authors demonstrate that NINJ1, a newly identified executioner of plasma membrane rupture across lytic cell death pathways, is a glycine target and resolve a longstanding mechanism of glycine cytoprotection.
A two-component protein condensate of EGFR and Grb2 regulates Ras activation at the membrane
Authors: Lin Chun-Wei , Nocka Laura M. , Stinger Brittany , DeGrandchamp Joey , Lew Nugent , Alvarez Steven , Phan Henry , Kondo Yasushi , Kuriyan John , Groves Jay T. 
Published: December 2021

ABSTRACTWe reconstitute a phosphotyrosine-mediated protein condensation phase transition of the ∼200 residue cytoplasmic tail of the epidermal growth factor receptor (EGFR) and the adaptor protein, Grb2, on a membrane surface. The phase transition depends on phosphorylation of the EGFR tail, which recruits Grb2, and the dimerization of Grb2, which provides the crosslinking element for condensation with EGFR. The Grb2 Y160 residue plays a structurally critical role in dimer formation, and phosphorylation or mutation of Y160 prevents EGFR:Grb2 condensation. By extending the reconstitution experiment to include the guanine nucleotide exchange factor, SOS, and its substrate Ras, we further find that EGFR condensation controls the ability of SOS to activate Ras. These results identify an EGFR:Grb2 protein condensation phase transition as a regulator of signal propagation from EGFR to the MAPK pathway.
Competition between hematopoietic stem and progenitor cells controls hematopoietic stem cell compartment size
Authors: Miao Runfeng , Chun Harim , Gomes Ana Cordeiro , Choi Jungmin , Pereira João P. 
Published: December 2021

SummaryCellular competition for limiting hematopoietic factors is a physiologically regulated but poorly understood process. Here, we studied this phenomenon by hampering hematopoietic progenitor access to Leptin receptor+ mesenchymal stem/progenitor cells (MSPCs) and endothelial cells (ECs). We show that HSC numbers increased by 2-fold when multipotent and lineage-restricted progenitors failed to respond to CXCL12 produced by MSPCs and ECs. HSCs were qualitatively normal, and HSC expansion only occurred when early hematopoietic progenitors but not differentiated hematopoietic cells lacked CXCR4. Furthermore, the MSPC and EC transcriptomic heterogeneity was remarkably stable, suggesting that it is impervious to dramatic changes in hematopoietic progenitor interactions. Instead, HSC expansion was caused by increased availability of membrane-bound stem cell factor (mSCF) on MSPCs and ECs due to reduced consumption by cKit-expressing hematopoietic progenitors. These studies revealed an intricate homeostatic balance between HSCs and proximal hematopoietic progenitors regulated by cell competition for limited amounts of mSCF.
Forty years of political skill and will in organizations: a review, meta-theoretical framework and directions for future research
Authors: Maher Liam P. , Ejaz Aqsa , Nguyen Chi Lan , Ferris Gerald R. 
Published: December 2021

PurposeThe purpose of this paper is to review the scholarship on political skill and political will so that the authors might inspire future work that assesses these constructs individually and in tandem.Design/methodology/approachThe “political skill” and “political will” concepts were introduced about 40 years ago, but they only have been measured and produced empirical results much more recently. Since that time, substantial research results have demonstrated the important roles political skill and political will play in organizational behavior. This paper provides a comprehensive review of this research, draws conclusions from this work and provides a meta-theoretical framework of political skill and political will to guide future work in this area.FindingsScholarship in this area has developed quite rapidly for political skill, but less so for political will. The authors hope that recent developments in a political will can set the stage for scholars to create a theoretical and empirical balance between these two related constructs.Originality/valueThe authors corral the vast and widespread literature on political skill and will and distill the information for scholars and practitioners alike.
Epistemological freedom: activating co-learning and co-production to decolonise knowledge production
Authors: Khan Maheen , Ruszczyk Hanna A. , Rahman Mohammad Feisal , Huq Saleemul 
Published: December 2021

PurposeThe purpose of the paper is to challenge and address the limitations of the traditional system of knowledge production that is embedded in disaster and climate change research studies, and research studies in general. It argues that knowledge production in research processes conforms to colonialist thinking or west-inspired approaches. Such a system often results in the omission of crucial information due to a lack of participation, inclusion and diversity in knowledge production.Design/methodology/approachThe paper proposes practices and recommendations to decolonise knowledge production in disaster and climate change research studies, and research studies in general. It provides a brief literature review on the concepts of decolonisation of knowledge and epistemological freedom, and its origins; assesses the need for knowledge decolonisation, emphasising on the integration of local knowledge from grassroots women-led initiatives in instances where disasters and crises are being investigated in vulnerable communities, especially in the Global South; and finally the paper proposes to decolonise knowledge production through activating co-learning and co-production. The practices have been developed from the work of relevant authors in the field and case studies.FindingsThrough a brief literature review on previous discourses on the topic of knowledge decolonisation and analysis of recent case studies on disaster and crisis management and community resilience, the paper finds that there exists a lack of pluralism and inclusion in epistemology which limits the pursuit to obtain the whole truth in the production of knowledge in research studies.Originality/valueThis paper adds to the discussion of decolonisation of knowledge in the field of disaster and climate change research studies, and research processes in general. It provides in-depth analyses of recent case studies of emerging community resilience and local practices that were crucial in the face of the coronavirus disease 2019 (COVID-19) crisis.
International acquisitions and efficiency and productivity of the Serbian cement industry
Authors: Savović Slađana , Mimović Predrag , Domanović Violeta 
Published: December 2021

PurposeThis paper explores the impact of international acquisitions on the efficiency and productivity of the cement industry in an emerging economy.Design/methodology/approachThe data envelopment analysis (DEA) and Malmquist index (MI) are used to calculate the partial efficiency and productivity of individual inputs (materials, labour and fixed assets), as well as the total factor efficiency and productivity during the period 2000–2018. DEA and MI are combined with bootstrapping to perform succinct statistical inferences for determining the accuracy of results. In this paper we apply the input-oriented CCR DEA Window model. With respect to the level of analysis, data was collected from individual companies and then aggregated data at the industry level.FindingsThe research results show that international acquisitions positively affect efficiency of the cement industry in the long term. Efficiency of capital is lower in the short period after acquisitions. Additionally, international acquisitions positively affect partial productivity, as well as total factor productivity of the cement industry.Practical implicationsThe results of the study may be significant for managers and policy makers to design appropriate strategies for the improvement of the cement industry performance over time.Originality/valueResearch in emerging economies related to subject matter is limited, and this is one of the earliest research studies which explore change in efficiency and productivity at the level of Serbian cement industry.
Investigating the constraints for managing the protection of historic buildings in remote areas of Saudi Arabia: a DEMATEL modelling approach
Authors: Sodangi Mahmoud , Kazmi Zaheer Abbas 
Published: December 2021

PurposeThe paper is aimed at identifying, analysing and prioritizing the critical constraints affecting efficient management of historic buildings in remote areas of Saudi Arabia.Design/methodology/approachThematic content analysis and expert-based evaluation approaches were used to identify and evaluate the constraints. The DEMATEL technique was deployed to define the interrelationship complexities between the constraints and evaluate the impact of these interrelationships to ascertain the influential constraints.FindingsThe results identify “lack of clearly defined roles for the multiple government agencies” as the most influential constraint for managing historic sites and buildings in remote areas of Saudi Arabia.Research limitations/implicationsThe contextual interrelationship between the constraints is due to the experts' perceptions, which may be biased due to their proficiencies and professional backgrounds. Since the evidence on which the findings of this paper are established is predominantly from experiences related to historic sites and buildings in remote areas of Saudi Arabia, the results of this paper may not be entirely applicable elsewhere.Practical implicationsThe paper provides invaluable methodology that can support practitioners and policymakers to establish sustainable strategies that can enhance the management and protection of historic buildings in remote areas of Saudi Arabia.Originality/valueThis study noticeably contributes to knowledge by providing comprehensive understanding of the major impediments to the successful management of historic buildings in remote areas of Saudi Arabia, which can assist in mitigating the potential impacts of these constraints and to advocate for the achievement of efficient management and protection of the historic sites and buildings.
Pets and people: information experience of multispecies families
Authors: Solhjoo Niloofar , Krtalić Maja , Goulding Anne 
Published: December 2021

PurposeThis paper introduces more-than-human perspective in information behaviour and information experience studies. The purpose of this paper is to contribute to understandings of the concept of multispecies families by exploring their significant dimensions related to information phenomena involving multiple contexts, situations, spaces, actors, species, and activities.Design/methodology/approachBased on previous research in human information behaviour and human-animal studies, our ideas around information experience of multispecies families are developed conceptually. The paper builds both on previous empirical findings about human information behaviour and the new domain of information experience.FindingsThe paper proposes a holistic approach both to information phenomena in everyday living with companion animals including embodied, affective, cognitive, social, digital, and objectual information that shapes pet care and management practices, and to the context of study, including work, domestic, and leisure aspects of multispecies family.Originality/valueThis study broadens our understanding of information phenomena in multispecies families, and so contributes to the field of information experience. It also provides insights for animal welfare scientists to help them understand the information behaviour of humans who are responsible for keeping and caring for animals.
Improving the detection and reporting of suspicious financial transactions: the Spanish case
Authors: Clavijo Suntura Joel Harry 
Published: December 2021

Purpose
The purpose of this paper is to analyze the obligation of regulated entities to detect unusual and suspicious transactions and to report them to external control bodies, as established by the Financial Action Task Force (FATF) recommendations, the European Community Directive and also the Spanish regulations for the Prevention of Money Laundering. This research paper also aims to create a model to identify and report suspicious transactions to improve financial institutions’ current procedures.

Design/methodology/approach
According to the Spanish regulations which comply with the FATF recommendations and the European Community Directive on the Prevention of Money Laundering, regulated entities must detect unusual and suspicious transactions. Within this framework, the present research work analyzes both criteria and procedures used by the regulated entities to report suspicious operations. It also assesses the efficiency of the reports sent to an external control body. For this purpose, both analytical and interpretative methods are used in this research paper.

Findings
In Spain, the current procedures followed by regulated entities to analyze unusual transactions are complex. This results in difficulties to report suspicious transactions involving money laundering. As a consequence, the cases of suspicious transactions reported to the external control body are often unclear and the related process is inefficient.

Originality/value
The creation of a harmonized model with the aim of detecting suspicious operations and analyzing them will improve the detection and the effectiveness of the suspicious operations procedure which are reported to the external control body. However, such unified model should take into account the currently used activities proposed by each financial institution.
Global sanctions against corruption and asset recovery: a European approach
Authors: Pavlidis Georgios 
Published: December 2021

Purpose
This paper aims to critically examine whether it is timely and actionable for the European Union (EU) to adopt a global sanctions regime against corruption and how such a regime can be designed to maximise its efficiency. This paper argues that developing such a dedicated framework is necessary, feasible and supportive of the international fight against corruption and the efforts to enhance the recovery of corruption proceeds.

Design/methodology/approach
This paper draws on reports, legislations, legal scholarships and other open-source data on global sanctions against corruption and the recovery of corruption proceeds.

Findings
This paper argues in favour of a dedicated global sanctions regime against corruption, which is necessary to mitigate significant risks for the EU internal market.

Originality/value
To the best of the authors’ knowledge, this study is one of the first to examine recent legislative developments, such as the EU Global Human Rights Sanctions Regime and the UK Global Anti-Corruption Sanctions Regulations, and the possible development of an EU-dedicated global sanctions regime against corruption with strong asset recovery components.
Does entrepreneur perception of the city’s decline matter to place attachment?
Authors: Wilkerson James M. , Sorokach Frank M. , Wafa Marwan A. 
Published: December 2021

Purpose
The purpose of this paper is to explore the association between local entrepreneurs’ perception of the city’s decline and their place attachment (measured in terms of commitment to the declining city and sense of how the declining city compares to other cities).

Design/methodology/approach
The authors surveyed entrepreneurs in a relatively small sample (N = 105) from a declining city of about 78,000 residents in the USA.

Findings
The authors found significant inverse correlations and found that, after controlling for length of residency, the entrepreneur’s perception of the city’s decline predicted lower place attachment. The authors also tested a moderation hypothesis and observed that, whereas professional-service entrepreneurs with both stronger and weaker perceptions of the city’s decline showed similar place attachment, non-professional entrepreneurs showed significantly more variation, displaying both the highest place attachment when weak in perceptions of the city’s decline and the lowest place attachment when strong in perceptions of the city’s decline.

Research limitations/implications
The authors discuss implications for place attachment, place image and place branding research, as well as for the study of place context’s effects on entrepreneurship.

Practical implications
Results hold implications for place branding’s participative development and for reasons to expect some difficulty in place branding when the context is a declining city.

Originality/value
Relative to prior research in place management, the research features a neglected segment of the city’s population, business owners, to study place attachment. Relative to prior entrepreneurship research, the authors advance the study of context’s effects on entrepreneurship by extending it to the place context of declining cities, which are not usually featured in entrepreneurship studies.