bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-scale Modeling of Polymeric Composites Including Nanoporous Fillers of Milled Anodic Alumina
Authors: Rafiee Roham , Eskandariyun Amirali , Larosa Claudio , Salerno Marco 
Published: September 2021

AbstractA polymer composite based on an innovative filler consisting of microscale powder of nanoporous alumina is modeled. The passing-through nanoscale pores in this system—roughly columnar cylindrical, with diameter of the order of 100 nm—are fully penetrated by the resin, which is not bonded to the inner pore walls by any chemical agent. This system, previously assessed by laboratory experiments, is modeled here for the first time, based on a computational multi-scale hierarchical approach. First, microscale representative volume element (RVE) is modeled in two steps using finite element modeling. Then, the macro-scale RVE is characterized, using a combination of micromechanical rules. The elastic response of the composite is simulated to predict its Young’s modulus. This simulation confirms the former experimental results and helps to shed light on the response of the investigated material, which may represent a novel system for use in disparate composite applications. In particular, the nanoporous microfillers composite is compared with a composite material containing the fillers of the same material yet nonporous, bonded to the matrix. It appears that, with respect to this standard concept of three-phase composites, the presence of the nanopores can compensate for the absence of the bonding agent.
Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamics
Authors: Keum Seula , Yang Soo Jung , Park Esther , Kang TaeIn , Choi Jee-Hye , Jeong Jangho , Hwang Ye Eun , Kim Jung-Woong , Park Dongeun , Rhee Sangmyung 
Published: September 2021

Abstract
Purpose
Spatiotemporal regulation of cell membrane dynamics is a major process that promotes cancer cell invasion by acting as a driving force for cell migration. Beta-Pix (βPix), a guanine nucleotide exchange factor for Rac1, has been reported to be involved in actin-mediated cellular processes, such as cell migration, by interacting with various proteins. As yet, however, the molecular mechanisms underlying βPix-mediated cancer cell invasion remain unclear.

Methods
The clinical significance of βPix was analyzed in patients with colorectal cancer (CRC) using public clinical databases. Pull-down and immunoprecipitation assays were employed to identify novel binding partners for βPix. Additionally, various cell biological assays including immunocytochemistry and time-lapse video microscopy were performed to assess the effects of βPix on CRC progression. A βPix-SH3 antibody delivery system was used to determine the effects of the βPix-Dyn2 complex in CRC cells.

Results
We found that the Src homology 3 (SH3) domain of βPix interacts with the proline-rich domain of Dynamin 2 (Dyn2), a large GTPase. The βPix-Dyn2 interaction promoted lamellipodia formation, along with plasma membrane localization of membrane-type 1 matrix metalloproteinase (MT1-MMP). Furthermore, we found that Src kinase-mediated phosphorylation of the tyrosine residue at position 442 of βPix enhanced βPix-Dyn2 complex formation. Disruption of the βPix-Dyn2 complex by βPix-SH3 antibodies targeting intracellular βPix inhibited CRC cell invasion.

Conclusions
Our data indicate that spatiotemporal regulation of the Src-βPix-Dyn2 axis is crucial for CRC cell invasion by promoting membrane dynamics and MT1-MMP recruitment into the leading edge. The development of inhibitors that disrupt the βPix-Dyn2 complex may be a useful therapeutic strategy for CRC.
Influence of Al2O3 content on mechanical properties of silica-based ceramic cores prepared by stereolithography
Authors: Zheng Wen , Wu Jia-Min , Chen Shuang , Wang Chang-Shun , Liu Chun-Lei , Hua Shuai-Bin , Yu Kang-Bo , Zhang Jie , Zhang Jing-Xian , Shi Yu-Sheng 
Published: September 2021

AbstractSilica ceramic cores have played an important part in the manufacture of hollow blades due to their excellent chemical stability and moderate high-temperature mechanical properties. In this study, silica-based ceramics were prepared with Al2O3 addition by stereolithography, and the influence of Al2O3 content on mechanical properties of the silica-based ceramics was investigated. The Al2O3 in silica-based ceramics can improve the mechanical properties by playing a role as a seed for the crystallization of fused silica into cristobalite. As a result, with the increase of Al2O3 content, the linear shrinkage of the silica-based ceramics first decreased and then increased, while the room-temperature flexural strength and the high-temperature flexural strength first increased and then decreased. As the Al2O3 content increased to 1.0 vol%, the linear shrinkage was reduced to 1.64% because of the blocked viscous flow caused by Al2O3. Meanwhile, the room-temperature flexural strength and the high-temperature flexural strength were improved to 20.38 and 21.43 MPa with 1.0 vol% Al2O3, respectively, due to the increased α-cristobalite and β-cristobalite content. Therefore, using the optimal content of Al2O3 in silica-based ceramics can provide excellent mechanical properties, which are suitable for the application of ceramic cores in the manufacturing of hollow blades.
A peduncle detection method of tomato for autonomous harvesting
Authors: Rong Jiacheng , Dai Guanglin , Wang Pengbo 
Published: September 2021

AbstractFor automating the harvesting of bunches of tomatoes in a greenhouse, the end-effector needs to reach the exact cutting point and adaptively adjust the pose of peduncles. In this paper, a method is proposed for peduncle cutting point localization and pose estimation. Images captured in real time at a fixed long-distance are detected using the YOLOv4-Tiny detector with a precision of 92.7% and a detection speed of 0.0091 s per frame, then the YOLACT +  + Network with mAP of 73.1 and a time speed of 0.109 s per frame is used to segment the close-up distance. The segmented peduncle mask is fitted to the curve using least squares and three key points on the curve are found. Finally, a geometric model is established to estimate the pose of the peduncle with an average error of 4.98° in yaw angle and 4.75° in pitch angle over the 30 sets of tests.
A novel deep learning method for detection and classification of plant diseases
Authors: Albattah Waleed , Nawaz Marriam , Javed Ali , Masood Momina , Albahli Saleh 
Published: September 2021

AbstractThe agricultural production rate plays a pivotal role in the economic development of a country. However, plant diseases are the most significant impediment to the production and quality of food. The identification of plant diseases at an early stage is crucial for global health and wellbeing. The traditional diagnosis process involves visual assessment of an individual plant by a pathologist through on-site visits. However, manual examination for crop diseases is restricted because of less accuracy and the small accessibility of human resources. To tackle such issues, there is a demand to design automated approaches capable of efficiently detecting and categorizing numerous plant diseases. Precise identification and classification of plant diseases is a tedious job due because of the occurrence of low-intensity information in the image background and foreground, the huge color resemblance in the healthy and diseased plant areas, the occurrence of noise in the samples, and changes in the position, chrominance, structure, and size of plant leaves. To tackle the above-mentioned problems, we have introduced a robust plant disease classification system by introducing a Custom CenterNet framework with DenseNet-77 as a base network. The presented method follows three steps. In the first step, annotations are developed to get the region of interest. Secondly, an improved CenterNet is introduced in which DenseNet-77 is proposed for deep keypoints extraction. Finally, the one-stage detector CenterNet is used to detect and categorize several plant diseases. To conduct the performance analysis, we have used the PlantVillage Kaggle database, which is the standard dataset for plant diseases and challenges in terms of intensity variations, color changes, and differences found in the shapes and sizes of leaves. Both the qualitative and quantitative analysis confirms that the presented method is more proficient and reliable to identify and classify plant diseases than other latest approaches.
Circular Steel: How Information and Actor Incentives Impact the Recyclability of Scrap
Authors: Compañero Reinol Josef , Feldmann Andreas , Tilliander Anders 
Published: September 2021

AbstractRecycling plays a vital role in preserving resources like steel and consequently in a circular economy. Scrap dealers and steel mills, the main business units in this system, often encounter opposing financial and sustainability incentives in using scrap as feedstock because regular sorting and scrap-preparation infrastructure cannot deal with the increasing complexity of steel scrap. Mismatches between the inputs and the target composition of the recycled steel result in trade-offs that favor the economics at the expense of resource efficiency. By examining literature and interviewing several actors, different scrap characteristics were identified as dimensions of scrap quality. Quality is typically associated with chemical composition, which is important, but this study aims to elaborate the concept of quality further and to connect it to the realities of scrapyard operations. Industry actors have different definitions for desired content, physical condition, shape and size, and homogeneity, based on their needs. Very few studies examine these details. Additionally, the relationship of quality and the level of information about the characteristics of the material was established. Having more definitive information on scrap increases opportunities for resource-efficient actions. This work offers an alternative perspective on how to address issues pertinent to recycling.
Graphical Abstract
Evaluation of Microfluidic Approaches to Encapsulate Cells into PEGDA Microparticles
Authors: White Kristopher A. , Chalaby Rabab , Olabisi Ronke 
Published: September 2021

Abstract
Purpose
Polyethylene glycol diacrylate (PEGDA) is increasingly used to microencapsulate cells via a vortex-induced water-in-oil emulsion process. Herein, we evaluated methods to encapsulate cells into microparticles using microfluidic methods.

Methods
PEGDA prepolymer solution with or without cells was photopolymerized with white light under varying microfluidic parameters to form empty microspheres or cell-laden microparticles. Microparticles and entrapped cells were assessed for size and viability.

Results
PEGDA microparticles were easily formed when cells were absent; the introduction of cells resulted in aggregation that clogged microfluidic devices, resulting in a mix of empty polymer microparticles and cells that were not encapsulated. Cells that were successfully encapsulated had poor viability.

Conclusion
Microfluidic methods may work for low density microencapsulation of mammalian cells; however, when the cell density within each microparticle must be relatively high, emulsion-based methods are superior to microfluidic methods.

Lay Summary
The synthetic polymer polyethylene glycol diacrylate (PEGDA) has been increasingly used to encapsulate cells into micrometer-sized hydrogel spheres (microspheres). One method to microencapsulate cells has been to form a water-in-oil emulsion with liquid polymer containing cells and then expose the suspended droplets to white light, polymerizing them into PEGDA hydrogel microspheres. Although successful, this method has poor control over the process, resulting in polydisperse microsphere sizes with varying cell density. We evaluated microfluidic methods to form both empty and cell-laden PEGDA microspheres. Although microfluidic methods resulted in monodisperse microsphere sizes, the introduction of cells resulted in clogging of microfluidic devices, non-spherical microparticles, and poor cell viability.

Future Work
Because the microfluidic approach successfully formed cell-free microspheres, the effect of reducing cell aggregation will be examined. Specifically, the use of anti-aggregation agents as well as a reduced cell density in the liquid polymer phase and their effects on polymer formation will be explored.
The psychological impact of COVID-19 quarantine on children, and the role of parental support and physical environment design
Authors: Aljunaidy Mais M. , Adi Mohamad Nadim 
Published: September 2021

AbstractCoronavirus disease 2019 is a contagious infection that caused a global lockdown and affected children who needed to stay home. There is a lack of knowledge about the role of parental stress and physical environment design on children’s mental wellbeing in quarantine. We hypothesis that COVID-19 quarantine affected child mental health, and that paternal stress or support, and child physical environment including household space, colors, sunlight exposure, and natural views, impacted child mental wellbeing in the quarantine. To assess the effect of quarantine on a child’s mental health, an online survey was administered globally through scientific organizations and social media. Those over 18 years old, and guardians of children were asked to participate in the survey. The survey was filled by 114 guardians from 31 countries. Descriptive statistics were used to summarize the data. Most participants experienced stress in the quarantine and reported child anxiety symptoms including focus reduction, sleeping difficulties, and appetite changes. Family fun activities and encouraging words, were mostly successful in reducing child anxiety. Reporting anxiety symptoms in children were more common in parents who had mental hardships compared to those who did not experience mental problems or had an improved mental status. Physical environment assessment showed that households with bright walls associated with fewer reports of child mental problems compared to households with neutral wall colors, and that most guardians thought that their children’s living space was not sufficient to play and study. Architects can provide evidence-based recommendations for customers to support children’s mental health.
The Economist's View of the World
Authors: Rhoads Steven E. 
Published: September 2021

Released in 1984, Steven E. Rhoads' classic was considered by many to be among the best introductions to the economic way of thinking and its applications. This anniversary edition has been updated to account for political and economic developments - from the greater interest in redistributing income and the ascendancy of behaviorism to the Trump presidency. Rhoads explores opportunity cost, marginalism, and economic incentives and explains why mainstream economists - even those well to the left - still value free markets. He critiques economics for its unbalanced emphasis on narrow self-interest as controlling motive and route to happiness, highlighting philosophers and positive psychologists' findings that happiness is far more dependent on friends and family than on income or wealth. This thought-provoking tour of the economist's mind is a must read for our times, providing a clear, lively, non-technical insight into how economists think and why they shouldn't be ignored.
Back to “normal”: the short-lived impact of an online NGO campaign of government discrimination in Hungary
Authors: Simonovits Gabor , Simonovits Bori , Vig Adam , Hobot Peter , Nemeth Renata , Csomor Gabor 
Published: September 2021

AbstractTo what extent can civil rights NGOs protect ethnic minorities against unequal treatment? We study this question by combining an audit experiment of 1260 local governments in Hungary with an intervention conducted in collaboration with a major Hungarian civil rights NGO. In the audit experiment we demonstrated that Roma individuals were about 13 percent-points less likely to receive responses to information requests from local governments, and the responses they received were of substantially lower quality. The intervention that reminded a random subset of local governments of their legal responsibility of equal treatment led to a short-term reduction in their discriminatory behavior, but the effects of the intervention dissipated within a month. These findings suggest that civil rights NGOs might face substantive difficulties in trying to reduce discrimination through simple information campaigns.
The Art of Running Away: Escapes and Flight Movements During the Great Depression in São Tomé e Príncipe, 1930–1936
Authors: Contreras Beatriz Valverde , Keese Alexander 
Published: September 2021

AbstractAs a coerced labour force living under repressive conditions, contract workers in São Tomé e Príncipe's cocoa plantations belong to a wider phenomenon of global plantation experience during the nineteenth and twentieth centuries. Flight appears as an important element of that experience and this article is an attempt to interpret the strategies of runaways in São Tomé's turbulent Great Depression years after 1930. The work set out here benefitted from a large selection of unexplored sources of the island's labour inspectorate, which can be found in the archipelago itself. Its analysis has enabled interpretation of the motives of escaping workers, and with it discussion of three principal strategic contexts of flight: the experiences of runaways who formed communities; attempts by escaped workers to hide and become part of “native” (forro) communities in rural areas or in the city of São Tomé; and the agency of workers trying to run away to subsequently renegotiate their conditions with labour inspectors or with plantation administrators sympathetic to their situation. The last part of the article attempts to locate that experience in the global history of runaways, connecting it with the types of “ecosystems of running” discussed for Atlantic slavery and later indentured labour systems.
Involuntary treatment in patients with anorexia nervosa: utilization patterns and associated factors
Authors: Mac Donald Benjamin , Bulik Cynthia M. , Larsen Janne T. , Carlsen Anders H. , Clausen Loa , Petersen Liselotte V. 
Published: September 2021

AbstractBackgroundA subgroup of patients with anorexia nervosa (AN) undergoing involuntary treatment (IT) seems to account for most of the IT events. Little is known about these patients and their treatment including the temporal distribution of IT events and factors associated with subsequent utilization of IT. Hence, this study explores (1) utilization patterns of IT events, and (2) factors associated with subsequent utilization of IT in patients with AN.MethodsIn this nationwide Danish register-based retrospective exploratory cohort study patients were identified from their first (index) hospital admission with an AN diagnosis and followed up for 5 years. We explored data on IT events including estimated yearly and total 5-year rates, and factors associated with subsequent increased IT rates and restraint, using regression analyses and descriptive statistics.ResultsIT utilization peaked in the initial few years starting at or following the index admission. A small percentage (1.0%) of patients accounted for 67% of all IT events. The most frequent measures reported were mechanical and physical restraint. Factors associated with subsequent increased IT utilization were female sex, lower age, previous admissions with psychiatric disorders before index admission, and IT related to those admissions. Factors associated with subsequent restraint were lower age, previous admissions with psychiatric disorders, and IT related to these.ConclusionsHigh IT utilization in a small percentage of individuals with AN is concerning and can lead to adverse treatment experiences. Exploring alternative approaches to treatment that reduce the need for IT is an important focus for future research.
Disrupted state transition learning as a computational marker of compulsivity
Authors: Sharp Paul B. , Dolan Raymond J. , Eldar Eran 
Published: September 2021

AbstractBackgroundDisorders involving compulsivity, fear, and anxiety are linked to beliefs that the world is less predictable. We lack a mechanistic explanation for how such beliefs arise. Here, we test a hypothesis that in people with compulsivity, fear, and anxiety, learning a probabilistic mapping between actions and environmental states is compromised.MethodsIn Study 1 (n = 174), we designed a novel online task that isolated state transition learning from other facets of learning and planning. To determine whether this impairment is due to learning that is too fast or too slow, we estimated state transition learning rates by fitting computational models to two independent datasets, which tested learning in environments in which state transitions were either stable (Study 2: n = 1413) or changing (Study 3: n = 192).ResultsStudy 1 established that individuals with higher levels of compulsivity are more likely to demonstrate an impairment in state transition learning. Preliminary evidence here linked this impairment to a common factor comprising compulsivity and fear. Studies 2 and 3 showed that compulsivity is associated with learning that is too fast when it should be slow (i.e. when state transition are stable) and too slow when it should be fast (i.e. when state transitions change).ConclusionsTogether, these findings indicate that compulsivity is associated with a dysregulation of state transition learning, wherein the rate of learning is not well adapted to the task environment. Thus, dysregulated state transition learning might provide a key target for therapeutic intervention in compulsivity.
Against ontological capture: Drawing lessons from Amazonian Kichwa relationality
Authors: Reddekop Jarrad 
Published: September 2021

AbstractThis article offers an experiment in theorising within or across a ‘space’ of ontological disagreement – which, as numerous authors have contended, characterises much that is at stake in relations between states and Indigenous peoples in the Americas. Such ontological disagreements, I argue, contain radical potential for disrupting globally dominant and anthropocentric patterns of thinking and relating, and for generating alternatives. I substantiate this point with reference to the relational ontologies informing different Indigenous ways of analysing and practicing existence. Drawing on Amazonian Kichwa thinking and Anishinaabe accounts of treaties, I show how these relational ontologies recast the problem of how it is possible to relate with difference, in such a way as to fold an inter-human ‘international’ into a continuum of relations that include human-nonhuman ones. Distinct normative horizons emerge. I argue that non-Indigenous people can draw a range of provocations here concerning our constitution as selves and the political space in which we understand ourselves to possibly participate. I also claim, however, that this more transformative potential is predominantly squandered through processes of what I call ontological capture, which troublingly re-entrench dominant construals of reality and forestall a more radical questioning and re-patterning of accompanying lifeways.
Collective Reasons and Agent-Relativity
Authors: Dietz Alexander 
Published: September 2021

AbstractCould it be true that even though we as a group ought to do something, you as an individual ought not to do your part? And under what conditions, in particular, could this happen? In this article, I discuss how a certain kind of case, introduced by David Copp, illustrates the possibility that you ought not to do your part even when you would be playing a crucial causal role in the group action. This is because you may have special agent-relative reasons against participating that are not shared by the group as a whole. I defend the claim that these are indeed cases in which you ought not to do your part in what the group ought to do. I then argue that we can expect these cases to produce a troubling kind of rational conflict.