bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormalities in lysine degradation are involved in the regulation of early stage compensated cardiac hypertrophy in pressure-overloaded rats
Authors: Liu Jialing , Hu Junhao , Tan Lanlan , Zhou Qi , Wu Xiaojing 
Published: May 2021

Abstract
Background
Cardiomyocyte metabolism changes before cardiac remodeling. However, its role in early detection of cardiac hypertrophy remains unclear. This study investigated the early changes in serum metabolomic in a pressure overload cardiac hypertrophy model induced by transverse aortic constriction (TAC).
Methods
The TAC model was constructed by partly ligating the aortic arch. Twelve Sprague-Dawley rats were randomly divided into the TAC group (n = 6) and sham group (n = 6). Three weeks after the surgery, cardiac echocardiography was performed to assess cardiac remodeling and function. HE and Masson staining were used to observe the pathologic changes. The plasma metabolites were detected by UPLC-QTOFMS and Q-TOFMS. The specific metabolites of the model were screened by orthogonal partial least squares discriminant analysis (OPLS-DA). The metabolic pathways were characterized by KEGG analysis, and the predictive value of the screened metabolites was analyzed by receiver operating characteristic (ROC) curve analysis.
Results
Three weeks after the surgery, the TAC and sham groups had similar left heart function and thickness of the interventricular septum and diastolic left ventricular posterior wall. However, in pathologic examination, the cross-sectional area of cardiac myocytes and the severity of myocardial fibrosis were significantly elevated in TAC rats. OPLS-DA analysis showed different metabolic patterns between TAC and sham groups. Based on the criterion of VIP > 1 and p < 0.05, 13 metabolites were screened out. KEGG analysis identified the disruption of the lysine degradation through the related metabolites 5-aminopentanoic acid, N6-acetyl-L-lysine, and L-lysine, with the AUC of 0.917, 0.889, and 0.806 in predicting compensated cardiac hypertrophy, respectively.
Conclusion
The disruption of lysine degradation might be involved in the early pathology of cardiac hypertrophy, and the related metabolites might be potential predictive and interventional targets for subclinical cardiac hypertrophy.
The Emission Mechanism of Gamma-ray Bursts from Supernovae
Authors: Postavaru Octavian , Craciun Marian 
Published: May 2021

Abstract

The connection between gamma ray bursts and supernovae is studied using a temperature-dependent vacuum model. A harmonically bound particle-antiparticle system is consistent with both Hawking radiation and Casimir effect, therefore, the Maxwell-Sellmeier model correlates the speed of light to temperature. According to quantum field theory, Lorentz invariance is violated only for temperatures larger than $4\times10^9$ K. Introducing in the temperature distribution of a 2D simulation for a type Ia supernova the speed of light temperature dependence proposed in this article, results a speed of light distribution. A theoretical snapshot of this distribution at an arbitrary distance is consistent with photon photo finish resulted from experiments. Variable speed of light shows that supernova is accompanied by gamma-ray bursts.
The impact of polymorphism in PNPLA3 and TM6SF2 genes on the susceptibility and survival of hepatitis C-related Hepatocellular carcinoma
Authors: Youssef Samar Samir , Abbas Eman Abd El Razek , Elfiky Asmaa M. , Seif Sameh , Nabeel Mohamed Mahmoud , Shousha Hend Ibrahim , Abdelaziz Ashraf Omar 
Published: May 2021

Abstract
Background: Genetic variants of Patatin-like phospholipase domain-containing protein3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2) genes have beenreported with development of hepatocellular carcinoma (HCC). Aim: To explore therole of The PNPLA3 rs738409 and TM6SF2 rs58542926 single nucleotidepolymorphisms (SNPs) on the incidence and survival of HCV induced HCC inEgyptians.Method: This case-control study included (120) HCC and (144) HepatitisC virus (HCV) patients. Baseline clinical, laboratory, tumor characteristics data, HCCrecurrence, and overall survival were collected. PNPLA3 rs738409 and TM6SF2rs58542926 polymorphism were detected by TaqMan allelic discrimination assay.Results: HCC Patients were significantly older with male predominance. A significantdifference between TT genotype of TM6SF2 frequency was observed in HCCcompared with HCV patients. Moreover, T allele of TM6SF2 distributions revealedsignificant contribution with different stages of HCC ( p =0.03). Both PNPLA3rs738409 and TM6SF2 rs58542926 variants showed significant relation with treatmentresponse according to the modified RECIST criteria. Age and diabetes mellitus werethe independent factors associated with the development of HCC by multivariateregression analysis. Diabetes, BCLC stage, performance status and response totreatment were significantly associated with patients’ survival.Conclusion : TM6SF2 rs58542926 polymorphism not PNPLA3 rs738409 could be implicated in thedevelopment HCV induced HCC and its progression.
Features of toll-like receptor type 9 expression on immunocompetent peripheral blood cells of patients with measles infection of varying severity
Authors: Veklych Kseniia , Popov Nikolay , Liadova Tetiana , Martynenko Alexander , Volobueva Olga , Hololobova Olesia , Sorokina Olga , Salyenkova Olena , Sarkis-Ivanova Vladislava 
Published: May 2021

Object of research: the level of the Toll-like receptor type 9 expression on peripheral blood lymphocytes and monocytes in patients with measles of varying severity, both with and without complications.
The solved problem: identification of the relationship between changes in the level of production of the main cytokines and virus-specific immunoglobulins and the level of expression of the Toll-like receptor type 9 on immunocompetent peripheral blood cells of patients with measles infection of varying severity.
The main scientific results: In patients with measles infection have been identified three types of cytokine response, each of which is characterized by different levels of changes in the expression of the main cytokines, immunoglobulins, and their avidity. It was shown that the levels of expression of major cytokines and virus-specific antibodies, as well as their avidity, are associated with the level of expression of the Toll-like receptor type 9. It has been demonstrated that moderate disease is associated with a significant increase in the level of expression of the Toll-like receptor type 9 on the immunocompetent peripheral blood cells, while their low expression leads to the development of severe forms of the disease. It has been shown that in moderate disease the risk of complications is associated with a lower level of expression of the Toll-like receptor compared to the group without complications. In groups of patients with a severe course of the disease a significant decrease in the level of expression of the Toll-like receptor type 9 was shown to be associated with the risk of complications.
The field of practical use of the research results: medical institutions specializing in the treatment of socially significant infectious diseases.
Innovative technological product: a method of advanced study of patients with and without measles infection of varying severity which allows to identify risk groups for the development of severe forms of the disease and complications, which in turn will allow the timely apply methods of immunomodulatory therapy and optimize the costs of the health system.
Scope of application of an innovative technological product: inpatient and outpatient treatment and diagnostics of patients with socially significant infectious diseases.
Yesus Sejarah atau Kristus Iman?: Historisitas Iman dan Karya Allah dalam Yesus Kristus
Authors: Wibowo Wahju Satria 
Published: May 2021

Abstract There has always been a tension between Jesus of History and Christ of Faith. The figure of Jesus and the faith in Him as Christ are historical. History is a space to bring together both. Without Jesus of History, Christian faith is empty. Similarly, without the faith of the first Christian community, the figure of Jesus is nothing. The historicity of Jesus stands along with the historicity of faith in Him. Of course, above all is God’s work in history. On the one hand, using the research and discussion of the historical Jesus, this article shows that archaeological findings should influence Christianity to reconstruct faith, and reflects that history is a medium for God’s work. On the other hand, using some other writings this article shows that the work of God in history is the art of God’s entrepreneurship, including God’s work in Jesus Christ. Incarnational theology is based on the historical figure, Jesus of Nazareth.
Abstrak Selalu ada ketegangan antara Yesus Sejarah dan Kristus Iman. Keduanya ada dalam sejarah manusia. Sosok Yesus dan iman kepada-Nya sebagai Kristus ada dalam sejarah. Sejarah adalah ruang untuk mempertemukan keduanya. Tanpa Yesus Sejarah, iman Kristen kosong. Di sisi lain, tanpa iman komunitas Kristiani pertama, sosok Yesus menjadi tidak terlalu penting. Historisitas Yesus berada bersama dengan historisitas iman kepada-Nya. Tentu saja, di atas segalanya ada karya Allah dalam sejarah. Dengan menggunakan penelitian dan pembahasan Yesus Sejarah, artikel ini membahas bahwa temuan Yesus Sejarah seharusnya memengaruhi kekristenan untuk membangun kembali iman, dan lalu akan merefl eksikan bahwa sejarah adalah media untuk pekerjaan Allah. Di sisi lain, dengan menggunakan beberapa tulisan lain artikel ini menunjukkan bahwa karya Allah dalam sejarah adalah “seni kewirausahaan Allah”, termasuk karya Allah dalam Yesus Kristus. Teologi inkarnasional didasarkan pada tokoh sejarah, Yesus dari Nazaret.
Parenting Styles, Anxiety and Depressive Symptoms in Child/Adolescent
Authors: Romero-Acosta Kelly , Gómez-de-Regil Lizzette , Lowe Gillian A. , Garth E. Lipps , Gibson Roger C. 
Published: May 2021

Objective: To analyse the possible direct and interactive associations of sex, age and parenting styles with symptoms of depression and anxiety. Methods: In this cross-sectional study, 710 students ranging from 8 to 13 years (mean age 10.8 years [±0.75]), the most of them males (n = 422,59.4%), completed three screening instruments: a parenting practices scale and two self-reports for evaluating anxiety and depressive symptoms. Two hierarchical multiple regression analyses were performed. Results: Authoritative (38.6%) and neglectful (38%) parenting styles were predominant. Symptoms of depression —F(3,706) = 3.12,p = .03— and anxiety —F(3,706) = 2.83,p = .4— differed by parenting styles. Students with a neglectful parenting style reported significant lower generalized anxiety symptoms than those whose parents used authoritative parenting. Clinical implications: Children ages 8 to 13 years-old with authoritative parenting style should be evaluated for possible presence of generalized anxiety symptoms.
Ablation of a life-threatening arrhythmia in a patient with Brugada syndrome
Authors: Kamel Omnia , Gamal Wessam , Tarek Aliaa , Ibrahim Walaa , Sayed Mohamed , Brugada Josep , Moreno Javier 
Published: May 2021

Brugada syndrome is an autosomal dominant arrhythmogenic disease associated with an increased risk of ventricular fibrillation and sudden cardiac death. The mainstay of treatment in high-risk patients is an implantable cardioverter-defibrillator (ICD), however radiofrequency ablation has been proposed over the past decade as an additional therapy in patients with recurrent ICD firing.We report a case of Brugada syndrome with an electrical storm which was successfully managed by radiofrequency ablation.
Why is the Incidence of Type 1 Diabetes Increasing?
Authors: Abela Alexia G. , Fava Stephen 
Published: May 2021

:
Type 1 diabetes is a condition that can lead to serious long-term complications and can
have significant psychological and quality of life implications. Its incidence is increasing in all
parts of the world, but the reasons for this are incompletely understood. Genetic factors alone cannot
explain such a rapid increase in incidence; therefore, environmental factors must be implicated.

:

Lifestyle factors have been classically associated with type 2 diabetes. However, there are data implicating
obesity and insulin resistance to type 1 diabetes as well (accelerator hypothesis). Cholesterol
has also been shown to be correlated with the incidence of type 1 diabetes; this may be mediated
by immunomodulatory effects of cholesterol. There is considerable interest in early life factors,
including maternal diet, mode of delivery, infant feeding, childhood diet, microbial exposure (hygiene
hypothesis), and use of anti-microbials in early childhood.

:

Distance from the sea has recently been shown to be negatively correlated with the incidence of
type 1 diabetes. This may contribute to the increasing incidence of type 1 diabetes since people are
increasingly living closer to the sea. Postulated mediating mechanisms include hours of sunshine
(and possibly vitamin D levels), mean temperature, dietary habits, and pollution. Ozone, polychlorinated
biphenyls, phthalates, trichloroethylene, dioxin, heavy metals, bisphenol, nitrates/nitrites,
and mercury are amongst the chemicals which may increase the risk of type 1 diabetes.

:

Another area of research concerns the role of the skin and gut microbiome. The microbiome is affected
by many of the factors mentioned above, including the mode of delivery, infant feeding, exposure
to microbes, antibiotic use, and dietary habits. Research on the reasons why the incidence of
type 1 diabetes is increasing not only sheds light on its pathogenesis but also offers insights into
ways we can prevent type 1 diabetes.
Treatment for Diabetic Peripheral Neuropathy: What have we Learned from Animal Models?
Authors: Yorek Mark 
Published: May 2021

Introduction:Animal models have been widely used to investigate the etiology and potential treatments for diabetic peripheral neuropathy. What we have learned from these studies and the extent to which this information has been adapted for the human condition will be the subject of this review article.Methods:A comprehensive search of the PubMed database was performed, and relevant articles on the topic were included in this review.Results:Extensive study of diabetic animal models has shown that the etiology of diabetic peripheral neuropathy is complex, with multiple mechanisms affecting neurons, Schwann cells, and the microvasculature, which contribute to the phenotypic nature of this most common complication of diabetes. Moreover, animal studies have demonstrated that the mechanisms related to peripheral neuropathy occurring in type 1 and type 2 diabetes are likely different, with hyperglycemia being the primary factor for neuropathology in type 1 diabetes, which contributes to a lesser extent in type 2 diabetes, whereas insulin resistance, hyperlipidemia, and other factors may have a greater role. Two of the earliest mechanisms described from animal studies as a cause for diabetic peripheral neuropathy were the activation of the aldose reductase pathway and increased non-enzymatic glycation. However, continuing research has identified numerous other potential factors that may contribute to diabetic peripheral neuropathy, including oxidative and inflammatory stress, dysregulation of protein kinase C and hexosamine pathways, and decreased neurotrophic support. In addition, recent studies have demonstrated that peripheral neuropathy-like symptoms are present in animal models, representing pre-diabetes in the absence of hyperglycemia.Conclusions:This complexity complicates the successful treatment of diabetic peripheral neuropathy, and results in the poor outcome of translating successful treatments from animal studies to human clinical trials.
Self-Care Needs and Technology Preferences Among Parents in Marginalized Communities: Participatory Design Study
Authors: Yuwen Weichao , Duran Miriana , Tan Minghui , Ward Teresa M , Cheng Sunny Chieh , Ramirez Magaly 
Published: May 2021

Background
Ten million parents provide unpaid care to children living with chronic conditions, such as asthma, and a high percentage of these parents are in marginalized communities, including racial and ethnic minority and low-income families. There is an urgent need to develop technology-enabled tailored solutions to support the self-care needs of these parents.

Objective
This study aimed to use a participatory design approach to describe and compare Latino and non-Latino parents’ current self-care practices, needs, and technology preferences when caring for children with asthma in marginalized communities.

Methods
The participatory design approach was used to actively engage intended users in the design process and empower them to identify needs and generate design ideas to meet those needs.

Results
Thirteen stakeholders participated in three design sessions. We described Latino and non-Latino parents’ similarities in self-care practices and cultural-specific preferences. When coming up with ideas of technologies for self-care, non-Latino parents focused on improving caregiving stress through journaling, daily affirmations, and tracking feelings, while Latino parents focused more on relaxation and entertainment.

Conclusions
Considerations need to be taken beyond language differences when developing technology-enabled interventions for diverse populations. The community partnership approach strengthened the study’s inclusive design.
IPDP geomagnetic pulsations and their relation to coronal holes and high speed solar wind streams
Authors: Bravo S. , Cruz Abeyro J. A. L. 
Published: May 2021

The frequency of occurrence of intervals of pulsations of diminishing periods (IPDP) has shown a very surprising inverse relation to the sunspot number. In this paper we take the annual frequency of occurrence of IPDPs at Sodankyla station for the period 1974 to 1985 and find that they correlate msitivelv with coronal hole area with a correlation coefficient of 0.77. This suggests a physical relationship between this kind of pulsations and the high speed streams (HSSs) in the solar wind coming from the holes. We compare the annual rate of lPDPs to the annual number of coronal-hole associated HSSs having a velocity equal to or higher than 550 kmls for the period from 1974 to 1982. We find a good agreement during the descending part of the solar cycle and around the maximum, but during the minimum and the first years of the ascending phase were more frequent than HSSs. We conclude that IPDPs are related to some solar wind characteristics in HSSs and we discuss a possible reason for the differences during the minimum.
PERBEDAAN HASIL BELAJAR MATEMATIKA PADA PENERAPAN MODEL PEMBELAJARAN DISCOVERY LEARNING DENGAN MODEL PEMBELAJARAN INQUIRY
Authors: Sumampou Petra C. M. , Ismaimuza Dasa , Hadjar Ibnu 
Published: May 2021

Abstrak: Tujuan penelitian ini adalah untuk mengkaji dan menganalisis perbedaan hasil belajar matematika antara siswa yang belajar menggunakan model pembelajaran discovery learning dengan siswa yang belajar menggunakan model pembelajaran inquiry di kelas X SMA Negeri 2 Palu, baik secara keseluruhan, antara siswa berkemampuan tinggi, antara siswa berkemampuan sedang dan antara siswa berkemampuan rendah. Hipotesis yang diajukan dalam penelitian ini yaitu terdapat perbedaan hasil belajar matematika antara siswa yang belajar menggunakan model pembelajaran discovery learning dengan siswa yang belajar menggunakan model pembelajaran inquiry di kelas X SMA Negeri 2 Palu, baik secara keseluruhan, antara siswa berkemampuan tinggi, antara siswa berkemampuan sedang dan antara siswa berkemampuan rendah. Subjek penelitian berjumlah 72 siswa yang terdiri dari 36 siswa kelas X MIA 3 sebagai kelas yang belajar menggunakan model pembelajaran inquiry dan 36 siswa kelas X MIA 5 yang belajar menggunakan model pembelajaran discovery learning. Materi yang dipelajari oleh siswa yaitu Sistem Persamaan Linear Tiga Variabel, Relasi dan Fungsi. Berdasarkan hasil perhitungan uji hipotesis untuk α = 0,05 diperoleh p > α untuk semua hipotesis, sehingga H1 ditolak dan H0 diterima untuk semua hipotesis. Dapat disimpulkan bahwa tidak terdapat perbedaan hasil belajar matematika antara siswa yang belajar menggunakan model pembelajaran discovery learning dengan siswa yang belajar menggunakan model pembelajaran inquiry di kelas X SMA Negeri 2 Palu, baik secara keseluruhan, antara siswa berkemampuan tinggi, antara siswa berkemampuan sedang dan antara siswa berkemampuan rendah.
Kata Kunci : perbedaan, hasil belajar, discovery learning, inquiry, sistem persamaan linear tiga variabel, relasi dan fungsi.
PENERAPAN METODE PENEMUAN TERBIMBING PADA MATERI HUBUNGAN ANTAR GARIS DAN SUDUT
Authors: Firmansyah Firmansyah , Jaeng Maxinus , Murdiana I Nyoman 
Published: May 2021

Abstrak: The purpose of this study is to describe the application of guided discovery method that can improve student learning outcomes VII A grade SMPN 18 Palu on the material connection between lines and angles. The type of research used is classroom action research (CAR). The research design refers to the research design of Kemmis and Mc. Taggart consists of four components: 1) planning, 2) action, 3) observation and 4) reflection. The type of data used is qualitative data and quantitative data with data collection techniques are observation, interviews, field notes and tests. This research was conducted in two cycles. The results showed that the application of guided discovery learning methods can improve student learning outcomes by following the steps of guided discovery methods are: 1) the formulation of the problem, the researcher explains the subject matter regarding the relationship between lines and angles, the researcher distributes student activity sheet which contains questions concerning the material relations between lines and angles that must be completed by students. 2) data processing and constructing conjectures, students process data in the student activity sheet and arrange conjectures. 3) Examining the conjecture, the researcher examines the conjectures that have been prepared by students and provides guidance as needed if there is an error in compiling the conjecture. 4) verbalizing the conjecture, student representatives from each group present the results of the conjecture obtained and the researcher guides students to make correct conclusions about the material relations between lines and angles. 5) feedback, giving practice questions about the material of relationships between lines and angles to students. The results of this study indicate that classical learning completeness students in the cycle I is 50% and increased in the cycle II is 77%.