bluuebunny/crossref_metadata_2025_split huggingface dataset:
RELATIONSHIPS BETWEEN SHORT-TERM BLOOD PRESSURE VARIABILITY AND LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN HYPERTENSIVE PATIENTS
Authors: Mulé Giuseppe , Guarino Laura , Nardi Emilio , Calandra Leonardo , Di Maggio Antonio , Sorce Alessandra , Mancia Ettore , Giambrone Marta , Imbrogio Vincenzo , Cottone Santina 
Published: April 2021

Objective:
Although an accurate assessment of fast blood pressure (BP) fluctuations occurring within the 24 hours, ideally requires continuous beat-to-beat recording, its assessment is also possible through non-invasive, intermittent 24 h ambulatory BP monitoring (ABPM) Short-term BP variability (SBPV) seems to be relevant to the pathophysiology of target organ damage and to the incidence of clinical events.
Our study was aimed to assess in hypertensive patients the relationships between some echocardiographic indices of DD and SBPV.

Design and method:
We enrolled 289 hypertensive subjects (age: 54 ± 16 years) recruited from those consecutively attending our Hypertension Centre. All the patients underwent: a 24-h ambulatory BP monitoring (ABPM) and an echocardiogram. We calculated the following indices of SBPV: standard deviation and average real variability (ARV) of diurnal and nocturnal systolic (SBP) and diastolic BP (DBP), 24 h weighted SD and ARV of SBP and DBP. Diastolic function was assessed by measuring from the mitral inflow profile, the E-wave (E) and A-wave (A) peak velocities, E/A ratio and E-deceleration time. Isovolumic relaxation time was calculated between aortic valve closure and the start of E-wave. Tissue Doppler imaging of the mitral annulus was obtained placing the sample volume in the lateral mitral valve annulus to evaluate: systolic peak velocity (Sm), early (Em) and late (Am) diastolic myocardial velocities. The E/em ratio was also calculated.

Results:
All the indices of systolic SBPV examined showed significant correlations with A-wave and with Em (p < 0.01). The correlations with the greatest strenght were those between Em and ARV of 24 h SBP (r = -0.273; p < 0.001) and between Em and weighted SD of 24 h SBP (r = -0.307; p < 0.001). These associations held even after adjustment in multiple regression models for confounders such as age, sex, average 24 h systolic BP and heart rate (p < 0.01).

Conclusions:
Our findings, showing an independent association between SBPV and some indices of diastolic dysfunction able to predict the development of heart failure, corroborate the concept that an increased short-term systolic BP variability may not be an innocuous phenomenon.
ASSOCIATION BETWEEN SHORT TERM BLOOD PRESSURE VARIABILITY AND ARTERIAL STIFFNESS IN SUSPECTED HYPERTENSIVES
Authors: Vieira Mateus Marchiori , Resende Luiz Antônio Pertili R. De , Resende Elizabeth Mantovani R. De , Filho Dalmo Correia , Neto Otavio Barbosa , Dias Valdo José , Resende José Augusto Mantovani De , Vieira Livia Marchiori , Moreira Guilherme Marchiori , Resende Ana Luísa Mantovani De , Silva Marco Antônio Vieira Da 
Published: April 2021

Objective:
To evaluate the association between arterial stiffness and short term blood pressure variability (BPV).

Design and method:
Four hundred fifty-five suspected hypertensive patients were referred to record a 24-hours ambulatory blood pressure monitoring (ABPM), and also were randomly enrolled from a population. They performed an oscillometric pulse wave analysis, using Mobil-O-Graph (I.E.M., Stolberg, Germany), following recommendations of Expert Consensus Document on the Measurement of Aortic Stiffness-2012. They also had a 24- hour of ABPM recorded. ABPM was made following protocols of European Guidelines. Short term BPV was evaluated by systolic or diastolic BP with: the standard deviation (SD) of 24 hs BP (24hBP-SD), Daytime BP-SD, Nighttime BP-SD, the 24 hs BP coefficient of variation (24hs CV), the weighted 24-h BP-SD and average real variability of 24-hour BP (ARV 24-h BP). Statistical Analysis: the Pearson correlation coefficient (r) was calculated by an univariate way comparing all systolic and diastolic BPV measures with brachial pulse wave analysis (bPWV). Partial correlation was adjusted to age and gender, and then for age, gender, 24 hs BP, and office BP do to avoid statistic influence of such confounders.

Results:
Data from 455 patients were analyzed. Clinical characteristics of the sample: age 48.8 ± 13.93 – women (41.9%), white people (69.5%), treated hypertensives (36%), diabetes (12.7%), statin use 22%, body mass index 28. 6 ± 5.8, smokers (8.6%), obese (36.3%). The findings are showed in table 1. All BPV variables had a significant correlation with bPWV. Daytime BP-SD and weighted 24-h BP-SD showed the best association. The worst results of the correlation were found, in systolic, in nighttime BP-SD, and in diastolic, in 24 hs CV. However, the comparison of diastolic 24hBP-SD and bPWV showed a negative correlation.

Conclusions:
Our data indicated an association between short blood pressure variability and oscillometric pulse wave velocity. A moderate correlation was demonstrated by systolic BPV and weak by diastolic. The best results of the association between the studied variables were shown in Daytime BP-SD and in weighted 24-h BP-SD.
BLOOD PRESSURE VARIABILITY IN TWO CONSECUTIVE BLOOD PRESSURE MEASUREMENTS IN HYPERTENSIVE AND NON-HYPERTENSIVE PATIENTS
Authors: Albuquerque Nila , Borges Samantha , Silva Liana Queren Lima , Silva Lais Vitoria , Rabelo Talita Maria , Lino Kecia , Rocha Fabian Elery , Araujo Thelma 
Published: April 2021

Objective:
The aim of this study was to compare blood pressure variability (BPV) in two consecutive blood pressure measurements in hypertensive and non-hypertensive patients.

Design and method:
A total of 92 patients from an outpatient clinic underwent two consecutive blood pressure measurements. The first one was using a calibrated aneroid sphygmomanometer and the second the HBP-1100 automatic blood pressure monitor. Auscultatory measurement was simultaneously performed by two trained observers using a dual-head teaching stethoscope and one supervisor who checked if differences between observers were less than or equal to 4 mmHg. Interval between measurements was at least 30 and at most 60 seconds. Blood pressure variability was defined as the standard deviation around the mean of the two systolic blood pressure (SBP) and diastolic blood pressure (DBP) readings. The paired sample t-test was used to determine whether there is a difference between the mean SBP and DBP variability in two observation sets, defined as hypertensive and non-hypertensive patients.

Results:
A total population of 92 from an outpatient clinic [66.3% female; mean age: 39.18 years; 32.61% hypertensives] underwent two consecutive blood pressure measurements in different methods. 184 valid blood pressure measurements were performed. Mean auscultatory SBP and DBP was 114.13 ± 17.95/ 69.48 ± 14.08 mmHg, respectively. Using the oscillometric method, mean SBP and DBP was 119.26 ± 16.94/71.89 ± 14.047 mmHg. Mean SBP difference between the two measurements was 5.13 ± 8.57 and 2.402 ± 6.85. SBP variability in hypertensive patients is statistically significantly higher (p = 0.01), whereas for DBP there is no significant difference (p = .0.78). Blood pressure variability in hypertensive patients with altered body mass index (BMI) was not statistically different (p = 0.30 and p = 0.56 for SBP and DBP, respectively).

Conclusions:
Increased SBP variability between two measurements was identified in hypertensive patients, regardless of BMI. As blood pressure variability is a recognized risk factor for cardiovascular events, its investigation should be included in the management of hypertensive care even in the interval between two blood pressure measurements.
IMPACT OF MODEL CHOICE WHEN STUDYING THE RELATIONSHIP BETWEEN BLOOD PRESSURE VARIABILITY AND RISK OF STROKE
Authors: De Courson Hugues , Ferrer Loic , Barbieri Antoine , Tully Phillip , Woodward Mark , Chalmers John , Leffondre Karen , Tzourio Christophe 
Published: April 2021

Objective:
Long-term blood pressure variability (BPV), an increasingly recognized vascular risk factor, is challenging to define and to analyze. In order to take into account two major methodological issues - conditioning on the future and uncertainty around BPV value - we compared different models on the risk of stroke in a large dataset

Design and method:
We used data from the PROGRESS trial, a secondary stroke prevention trial which included 6105 subjects followed-up during 4 years. The median number of BP measurements was 12 and 727 strokes occurred. We compared a naive Cox model including BPV as a fixed covariate calculated on the entire follow-up, to other models aimed at avoiding conditioning on the future and taking into account uncertainty around BPV value.

Results:
We found that BPV was associated with an increased risk of stroke when using a naive Cox Model (HR = 1.19, 95% CI: 1.10 – 1.30) but not when using other models dealing more appropriately with the issue of conditioning on the future.

Conclusions:
These results illustrate that the methods used to estimate the association between BPV and stroke may affect the estimates and that more appropriate models tend to reduce this association.
THE INFLUENCE OF RENAL DENERVATION ON BLOOD PRESSURE VARIABILITY IN PATIENTS WITH RESISTANT HYPERTENSION
Authors: Anna Moiseeva , Alexandru Caraus , Nicolae Ciobanu , Vitalie Moscalu , Oleg Calenici , Angela Bitca , Nadejda Sapojnic , Mihaela Caraus 
Published: April 2021

Objective:
Comparative evaluation of the impact of renal denervation versus pharmacological treatment with sympathetic nervous system (SNS) blockers on blood pressure variability in patients with resistant hypertension.

Design and method:
75 patients with resistant hypertension without comorbidities after a 3-week standardized treatment with Losartan, Amlodipine and Indapamide and confirmation of their resistance were randomized into three groups, depending on medication supplimented to the previously administred: group I M - selective I1-imidazoline agonist Moxonidine, group II B – cardioselective beta-blocker Bisoprolol, group III D – renal artery denervation (RDN). Blood pressure variability assessed by ambulatory blood pressure monitoring (ABPM) were determined at baseline, 3 and 6 months follow-up.

Results:
The media/day and media/night systolic blood pressure (SBP) variability increased at the baseline in all three groups was reduced statistically significant from 3 months of monitoring, reaching the maximum effect towards the end of the study, when its normal values were recorded in all observational groups.
Although treatment group supplimented with Moxonidine demonstrated an effect superior to that with Bisoprolol, and RDN - superiority to both, all three schemes had an authentic dynamics in improving SBP at 6 months of evaluation (p < 0,001) (Fig.1).
The evolution of diastolic blood pressure (DBP) media/day and media/night variability noted a beneficial effect, starting with 3 months, the improvement of this parameter being maintained until the end of the study. Although the reduction of DBP variability was statistically authentic in all three groups at all stages of evaluation, the Bisoprolol treatment group noted a smaller effect in improving this parameter, the higher net effect being manifested by the RDN patients group (p < 0,001) (Fig.2).

Conclusions:
RDN in patients with resistant hypertension reduced statistically significant SBP and DBP variability starting with 3 months of follow-up and reaching maximum effect at the end of the study, simultaneously demonstrating superiority over treatment with SNS blockers.
ANTIHYPERTENSIVE TREATMENTS AND RISKS OF LUNG CANCER: A LONG-TERM RETROSPECTIVE COHORT STUDY IN HONG KONG
Authors: Li Jinhui , Lam Amy Sm , Yau Sarah Ty , Yiu Karen Kl , Tsoi Kelvin Kf 
Published: April 2021

Objective:
There remains a lack of strong evidence to identify the association between antihypertensive treatments (AHTs) and the risk of lung cancer. We studied the relationship between AHTs and the risk of lung cancer for further investigation.

Design and method:
The Aspirin Cohort was conducted from 2000 to 2013. The adjusted hazard ratio (HR) with 95% confidence intervals (95% CIs) was assessed for lung cancer risk through Cox proportional hazards models with inverse probability weighting. The cumulative duration of usage was also considered.

Results:
Among all the participants, 8,618 used aspirin only, 238,663 used AHT only, and 182,747 used both aspirin and antihypertensive, with lung cancer incidence rates of 2.5%, 2.8%, 2.4%, and 3.7% respectively. The mean age was 67.5 (SD = 12.0) years old. Among the classes of AHT, the lung cancer incidence rates for ACEi/ARB, CCB, alpha-blocker, and beta-blocker were 1.6%, 2.5%, 3.9%, and 2.2% respectively. Compared to the patients from the control group, the overall lung cancer risk decreased significantly (HR: 0.63, 95% CI: 0.60–0.66) for the patients who accepted AHT. For specific classes of AHTs, there were significant association between ACEi/ARB (HR: 0.45, 95% CI: 0.32–0.62), alpha-blocker (HR: 0.64, 95% CI: 0.54–0.76), and beta-blocker (HR: 0.79, 95% CI: 0.65–0.96) usage and decreased lung cancer risk. When aspirin and alpha-blocker were used simultaneously, it reduced the risk of lung cancer significantly (HR: 0.53, 95% CI: 0.34–0.84). Moreover, as the follow-up period went on, the use of AHTs was still associated with a decreased risk of lung cancer after 5-year (HR: 0.60, 95% CI: 0.57–0.63) and 7-year (HR: 0.63, 95% CI: 0.60–0.66) of usage. Similar effects were also identified for the combination usage of aspirin and ATHs. Specifically, analyses by the different duration of follow-ups for ACEi/ARB and alpha-blocker treatment also revealed significantly decreased lung cancer risk consistently.

Conclusions:
Long-term AHTs among the Chinese population might lower the risk of lung cancer. This study should offer further reassurance to patients using AHTs, but more evidence is warranted to address the effects of these drugs on the risk of lung cancer.
EVALUATION OF CARDIOVASCULAR COMPLICATIONS AT CHRONIC HEMODIALYSIS
Authors: Zemmouchi Souheila , Amiar Billel , Tebbani Rachida 
Published: April 2021

Objective:
Despite the effectiveness of dialysis in the treatment of uremic death, chronic hemodialysis patients have a reduced life expectancy, largely related to the development of a very frequent, often early and sometimes severe and concealed cardiovascular damage in these patients. Throughout this study, we set out to determine the frequency of cardiovascular complications at the dialysis center of Constantine's EHS and to define the main cardiovascular risk factors

Design and method:
A cross-sectional, mono-centric descriptive study type, over a two-year period, from January 1, 2016 to December 31, 2017, including 117 hemodialysis patients at EHS Daksi Constantine

Results:
Subclinical cardiovascular complications were the most frequent, namely left ventricular hypertrophy (78%) and valvular calcification (13%), and a combination of several cardiovascular complications was observed. Two-thirds of our population was hypertensive. MAPA demonstrated the non-Dipper character in 74% of hypertensive patients, which is strongly correlated with an increase in left ventricular mass. The cardiovascular mortality rate related to coronary insufficiency (IDM and sudden death) is very high in our series (60%).

Conclusions:
Hemodialysis is a purification technique that exposes patients to multiple cardiovascular complications.
MAGNESIUM AND TAURINE, FIRST PROVEN TO BE PREVENTIVE NUTRIENTS IN STROKE-PRONE RAT MODELS WERE 24-H URINARY BIO-MARKERS ASSOCIATED WITH LOWER CV RISKS WORLD-WIDELY, ALSOINJAPANESE AND MEDITERRANEAN POPULATIONS
Authors: Yamori Yukio , Sagara Miki , Mori Hideki , Mori Mari 
Published: April 2021

Objective:
Since stroke was prevented by taurine(T)- and magnesium(Mg)-rich diets even in salt-loaded stroke-prone SHR models, we examined the association of 24-hour urinary(24U) T and Mg/creatinine (C) ratios with cardiovascular risks (CVR) world-wide and studied these biomarkers in Japanese and Mediterranean populations (J, M) in comparison with Euro-Western populations(EW).

Design:
The association of 24U T and Mg/C with CVR was cross-sectionally analyzed among 4211 participants, 49.7% females(F), aged 48–56 years in 50 populations from 22 countries according to the WHO-CARDIAC study protocol and further analyzed comparatively in 6 J (864, 53.8%F), 6 M(574, 50.2%,F from Greece, Sicily, Italy, Spain, Portugal) and 6 EW(549,45.9% F from Sweden,Ireland, Scotland, Canada, Australia,New Zealand).

Design and method:
In a world-wide linier regression analysis, T/C and Mg/C were inversely associated with BMI, systolic and diastolic blood pressure (SBP, DBP) and serum total cholesterol (TC) significantly (P for linear trend <0.001, respectively). The prevalence of obesity, hypertension and hypercholesterolemia among the subjects of the lowest quintile of T/C (Mg/C) was 2.84 (2.49), 1.22 (1.49) and 2.20 (2.39) times higher (P < 0.05 or <0.001) than those in the subjects of the highest quintile.
In a comparison of J and M (both males and females) with EW, 24U T and Mg/C in both populations were significantly higher than in EW, and SBP, DBP, TC and non-HDL cholesterol were significantly lower in J and M, despite their significantly higher 24U salt, than in EW, indicating that these biomarkers could contribute to lower coronary heart disease mortality, benefiting longevity in J and M.

Conclusion:
T and Mg are regarded as beneficial dietary factors for reducing CVR world-wide and are related with the merits of J and M diets compared with EW diets despite the higher salt intake, indicating that low salted T- and Mg-rich dietary intakes are recommendable for promoting CVR reduction.
ASSOCIATION BETWEEN THE VISCERAL ADIPOSITY INDEX AND HYPERTENSION-MEDIATED ORGAN DAMAGE IN THE COMMUNITY-DWELLING ELDERLY CHINESE: THE NORTHERN SHANGHAI STUDY
Authors: Xu Chong , Zhao Song , Yu Shikai , Chi Chen , Fan Ximin , Ji Hongwei , Teliewubai Jiadela , Zhang Yi , Xu Yawei 
Published: April 2021

Abstract

Objective:
The visceral adiposity index (VAI) was a novel indicator of visceral fat function and insulin resistance. Numerous studies had investigated that the VAI was associated with cardiovascular damage. However, few data are found on the correlation of VAI and hypertension-mediated organ damage (HMOD). We aimed to evaluate the association of HMOD with the VAI in the community-dwelling elderly Chinese population.

Design and method:
A cohort of 3363 elderly participants was recruited from June 2014 to August 2019. The relationship between the VAI and cardiometabolic risk factors was analyzed by Pearson's correlation. We used multivariable linear and logistic regression analysis to verify the relationship between the VAI and HMOD.

Results:
The VAI was significantly correlated with cardiometabolic risk factors (P < 0.001). In multivariable linear regression analysis, the VAI was associated with carotid-femoral pulse wave velocity (cf-PWV; b = 0.047, P = 0.024), ankle-brachial index (ABI; b = -0.003, P = 0.022), urine albumin to creatinine ratio (UACR; b = 3.893, P = 0.008), estimated glomerular filtration rate (eGFR; b = -0.526, P = 0.003). After the VAI was put into the multivariable logistic regression model, higher VAI was significantly related to cf-PWV > 10m/s (OR = 1.50, [95% CI, 1.12–2.00]; P = 0.006), micro-albuminuria (OR = 1.32, [95%CI, 1.03–1.70]; P = 0.019) and chronic kidney disease (OR = 1.56, [95% CI, 1.03–2.37]; P = 0.031).

Conclusions:
Higher VAI might be related to an increased risk of arterial stiffness and kidney damage. The VAI may be used as a tool to evaluate early HMOD in the elderly Chinese population.
POLYMORPHISM ROLE OF GNB3 GENE IN THE DEVELOPMENT OF LEFT VENTRICULAR HYPERTROPHY OF PATIENTS WITH PRIMARY ARTERIAL HYPERTENSION
Authors: Voroniuk Kseniia , Sydorchuk Larysa , Petrynych Oksana , Biletsky Semen , Kazantseva Tetiana , Repchuk Yuliia , Semianiv Marianna , Sokolenko Alina 
Published: April 2021

Abstract

Objective:
To analyze the distribution of polymorphic variants of the guanine gene of the binding G protein of the beta-3 subunit (GNB3) of patients with primary arterial hypertension;

Design and method:
In a single-step study, 72 patients with EH II-nd stage, 1–3 degrees of raising blood pressure, high and very high cardiovascular risk occurred. Patients’ gender consists of 29.16% (21) of men, 70.84% (51) of women. The average age of the patients is 59.87 ± 7.98 yr. The control group consisted of 48 healthy individuals, comparable in age (43.36 ± 7.1 yr.) and sexual division (62.5% for women, 37.5% for men). A study of the 825C > T polymorphism of the GNB3 gene has been performed by real-time BDP.

Results:
The genetic marker 825C > T of the GNB3 gene polymorphism (rs5443) is determined by replacing thymine (T) with cytosine (C) in the gene position with 825 DNA (12p13). Substitution of C with T in the GNB3 protein at position 825 of the amino acid sequence is accompanied by impaired replication of the 9th exon, which leads to the loss of a portion of the polypeptide chain, consisting of 41 amino acids. Genotypes division inpatient group with EH and in the observation group are as follows: the TT genotype is found in 8.33% (6) patients and 4.16% (2) of the control group, the Tt genotype in 41.66% (30) and 50% (24), respectively, the tt genotype is found in 50% (36) of patients and in 45.83% (22) of practically healthy patients (p < 0.05). The partition of polymorphic variants corresponded to the population balance of Hardy-Weinberg (x2 = 3.28, p > 0.05). The relative frequency of the wild C-allele and the mutational T-allele (PT = 0.24; PC = 0.71) does not differ between the research and control groups (x2 < 1.0; p > 0.05). The studied polymorphism of the GNB3 gene (5443) is not associated with an increased risk of EH [OR = 1.18; 95% CI: 0.56–2.46; p > 0.05].

Conclusions:
The alleles and genotypes of 825C > T polymorphism of the GNB3 gene (rs5443) are not risk factors for the development of EH in the examined.