bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERLINDUNGAN HUKUM TERHADAP PENCIPTA LAGU “LAGI SYANTIK” ATAS PERUBAHAN LIRIK TANPA IZIN PEMEGANG HAK CIPTA
Authors: Junita Lully Tiyas 
Published: July 2021

ABSTRACTCopyright is an exclusive right that arises automatically based on declarative principles after the creation is in real or visualized form. Legal protection for songwriters is regulated in Law Number 28 of 2014 concerning Copyright. This research covers two main problems. First one, how is the implementation of copyright infringement on the song "Lagi Syantik" which is sung without permission from the copyright holder? The second, how is the legal protection of authors for songs whose lyrics have been changed without the permission of the copyright holders? This paper uses normative juridical research. This research uses 2 types of approaches, such as the statute approach and the case approach. The result of the research were the cover version of the song is not a prohibited activity if it is carried out based on applicable legal regulations and legal protection for copyright holders is regulated in the Copyright Law, Criminal Law, and Civil Law. Keyword: Copyright, The Copyright Holder, Legal Protection, Song. ABSTRAKHak Cipta adalah hak eksklusif yang timbul secara otomatis berdasarkan prinsip deklaratif setelah ciptaan sudah dalam bentuk nyata atau sudah divisualkan. Perlindungan hukum untuk pencipta lagu telah diatur di dalam Undang-Undang Nomor 28 Tahun 2014 tentang Hak Cipta. Permasalahan penelitian ini meliputi yaitu Pertama, bagaimana bentuk pelanggaran hak cipta atas lagu “Lagi Syantik” yang dinyanyikan ulang tanpa izin dari pemegang hak cipta? Kedua, bagaimana perlindungan hukum terhadap pencipta atas lagu yang diubah lirik tanpa seizin pemegang hak cipta?. Penulisan ini menggunakan penelitian yuridis-normatif. Penelitian ini menggunakan 2 jenis pendekatan, yakni pendekatan perundang-undangan (statute approach) dan pendekatan kasus (case approach). Hasil dari penelitian ini adalah cover version lagu bukan kegiatan yang dilarang jika dilakukan sesuai aturan hukum yang berlaku dan perlindungan hukum terhadap pemegang hak cipta diatur dalam Undang-Undang Hak Cipta, Hukum Pidana, dan Hukum Perdata. Kata Kunci: Hak Cipta, Pemegang Hak Cipta, Perlindungan Hukum, Lagu
INHERITANCE DISTRIBUTION FOR "KHUNTHA MUSHKIL" (SISSY) IN ISLAM:
Authors: Abizar Mukhammad Hafidz 
Published: July 2021

This article is result of library research with a normative legal approach. Legal materials and data were obtained from Islamic legal norms regarding inheritance and khuntsa obtained from the texts of the Qur'an and Hadith, as well as the opinions of the jurists. This thesis discusses the distribution of khuntsa inheritance based on the opinion of Imam Ali As-Shobuni and Imam Abu Hanifah. People who do not have a clear gender status, not male and not female, are called khuntsa in Islamic law. One of the problems of khuntsa is in determining the right of inheritance. The Qur'an does not clearly state the portion of khuntha inheritance. This study concludes that in the unclear gender of khuntsa, it can be determined by two things, namely first, signs of maturity and second, where does urine come from. This argument is put forward using the istidlal theory used by Imam Ali As-Shobuni and Imam Abu Hanifah. If a khuntsa has a clear gender status, then this status follows the law of inheritance
Keyword : Khuntha mushkil, sissy, inheritance.

Abstrak
Artikel ini adalah hasil dari penelitian kepustakaan dengan pendekatan hukum normatif. Bahan hukum dan data diperoleh dari norma- norma hukum Islam tentang kewarisan dan khuntsa yang diperoleh dari nash al-Qur‟an dan Hadits, serta pendapat para fuqaha‟. Tesis ini mendiskusikan pembagian warisan khuntsa berdasarkan pendapat Imam Ali As-Shobuni dan Imam Abu Hanifah. orang yang tidak mempunyai status jenis kelamin yang jelas, bukan laki-laki dan bukan perempuan disebut dengan istilah khuntsa dalam hukum islam. Salah satu dari permasalahan khuntsa adalah dalam hal menentukan hak kewarisannya. Al-Qur‟an tidak menyebutkan secara jelas bagian waris khuntha. Penelitian ini menyimpulkan bahwa dalam ketidak jelasan jenis kelamin khuntsa, dapat ditentukan dengan dua hal, yaitu pertama, tanda-tanda kedewasaannya dan kedua, darimana ia mengeluarkan air kencing. Argumen ini diajukan dengan menggunakan teori istidlal yang digunakan oleh Imam Ali As-Shobuni dan Imam Abu Hanifah. Bila seorang khuntsa telah jelas status jenis kelaminnya, maka status ini mengikuti pada hukum kewarisannya.
Kata Kunci : Khuntha mushkil, banci, pembagian waris
HAPPY FAMILY ("SAKINAH" ) OF TAHFID PESANTREN ALUMNI: Marriage Counseling Approach
Authors: Machmudz Machmudz 
Published: July 2021

This article is a result of a qualitative field research. This article discusses efforts to form a sakinah family. The research location is Jombang Regency. The data of this research are alumni of Madrasatul Qur'an Islamic boarding school Tebuireng Jombang who are domiciled in Jombang Regency. This study concludes that marriage counseling to maintain household harmony, one of which can be done independently through istiqamahan interacting with the Qur'an. This argument is based on data from the family of alumni who have memorized the Koran PP. Madrasataul Qur'an Tebuireng in Diwek district, Jombang. The alumni practice the routine of memorizing the Qur'an, always remembering Allah (taqarrub), tadarus Al-Qur`an every day, praying in congregation, being open between family members. The alumni carry out several family functions, namely educational, religious, protective, economic, and recreational functions.
Keywords: marriage counseling, happy family, pesantren alumni.

Abstrak
Artikel ini adalah hasil penelitian kualitatif lapangan. Artikel ini mendiskusikan upaya membentuk keluarga sakinah. Lokasi penelitian berada Kabupaten Jombang. Data penelitian ini adalah alumni pondok pesantren Madrasatul Qur’an Tebuireng Jombang yang berdomisili di Kabupaten Jombang. Penelitian ini menyimpulkan bahwa konseling pernikahan untuk menjaga keharmonisan rumah tangga salah satunya dapat dilakukan secara mandiri melalui keistiqamahan berinteraksi dengan Al-Qur’an. Argumen ini didasarkan pada data Keluarga alumni penghafal Al-Qur`an PP. Madrasataul Qur`an Tebuireng di kecamatan Diwek Jombang. Para alumni mempraktekkan rutinitas menghafal Al-Qur`an, selalu bedzikir kepada Allah (taqarrub), tadarus Al-Qur`an setiap hari, shalat berjamaah, bersikap terbuka antar anggota keluarga. Para alumni menjalankan beberapa fungsi keluarga, yakni fungsi edukatif, religi, protektif, ekonomis, dan rekreatif.
Kata Kunci: konseling perkawinan, keluarga bahagia, alumni pesantren.
Mechanical Parameters and Trajectory of Two Chinese Cervical Manipulations Compared by a Motion Capture System
Authors: Huang Xuecheng , Lin Dongxin , Liang Zeyu , Deng Yuping , He Zaopeng , Wang Mian , Tan Jinchuan , Li Yikai , Yang Yang , Huang Wenhua 
Published: July 2021

Objective: To compare the mechanical parameters and trajectory while operating the oblique pulling manipulation and the cervical rotation–traction manipulation.Methods: An experimental research measuring kinematics parameter and recording motion trajectories of two cervical manipulations were carried out. A total of 48 healthy volunteers participated in this study, who were randomly divided into two groups of 24 representing each of the two manipulations. A clinician performed two manipulations in two groups separately. A motion capture system was used to monitor and analyze kinematics parameters during the operation.Results: The two cervical manipulations have similar thrust time, displacement, mean velocity, max velocity, and max acceleration. There were no significant differences in active and passive amplitudes between the two cervical rotation manipulations. The thrust amplitudes of the oblique pulling manipulation and the cervical rotation–traction manipulation were 5.735 ± 3.041° and 2.142 ± 1.742°, respectively. The thrust amplitudes of the oblique pulling manipulation was significantly greater than that of the cervical rotation–traction manipulation (P &lt; 0.001).Conclusion: Compared with the oblique pulling manipulation, the cervical rotation–traction manipulation has a less thrust amplitudes.
Diabetic Uterine Environment Leads to Disorders in Metabolism of Offspring
Authors: Dong Ming-Zhe , Li Qian-Nan , Fan Li-Hua , Li Li , Shen Wei , Wang Zhen-Bo , Sun Qing-Yuan 
Published: July 2021

AimsResearch evidence indicates that epigenetic modifications of gametes in obese or diabetic parents may contribute to metabolic disorders in offspring. In the present study, we sought to address the effect of diabetic uterine environment on the offspring metabolism.MethodsType 2 diabetes mouse model was induced by high-fat diet combined with streptozotocin (STZ) administration. We maintained other effect factors constant and changed uterine environment by zygote transfers, and then determined and compared the offspring numbers, symptoms, body weight trajectories, and metabolism indices from different groups.ResultWe found that maternal type 2 diabetes mice had lower fertility and a higher dystocia rate, accompanying the increased risk of offspring malformations and death. Compared to only a pre-gestational exposure to hyperglycemia, exposure to hyperglycemia both pre- and during pregnancy resulted in offspring growth restriction and impaired metabolism in adulthood. But there was no significant difference between a pre-gestational exposure group and a no exposure group. The deleterious effects, no matter bodyweight or glucose tolerance, could be rescued by transferring the embryos from diabetic mothers into normal uterine environment.ConclusionOur data demonstrate that uterine environment of maternal diabetes makes critical impact on the offspring health.
Stability of Maleimide-PEG and Mono-Sulfone-PEG Conjugation to a Novel Engineered Cysteine in the Human Hemoglobin Alpha Subunit
Authors: Cooper Chris E. , Bird Matthew , Sheng XiaoBo , Choi Ji-Won , Silkstone Gary G.A. , Simons Michelle , Syrett Natalie , Piano Riccardo , Ronda Luca , Bettati Stefano , Paredi Gianluca , Mozzarelli Andrea , Reeder Brandon J. 
Published: July 2021

In order to use a Hemoglobin Based Oxygen Carrier as an oxygen therapeutic or blood substitute, it is necessary to increase the size of the hemoglobin molecule to prevent rapid renal clearance. A common method uses maleimide PEGylation of sulfhydryls created by the reaction of 2-iminothiolane at surface lysines. However, this creates highly heterogenous mixtures of molecules. We recently engineered a hemoglobin with a single novel, reactive cysteine residue on the surface of the alpha subunit creating a single PEGylation site (βCys93Ala/αAla19Cys). This enabled homogenous PEGylation by maleimide-PEG with &gt;80% efficiency and no discernible effect on protein function. However, maleimide-PEG adducts are subject to deconjugation via retro-Michael reactions and cross-conjugation to endogenous thiol species in vivo. We therefore compared our maleimide-PEG adduct with one created using a mono-sulfone-PEG less susceptible to deconjugation. Mono-sulfone-PEG underwent reaction at αAla19Cys hemoglobin with &gt; 80% efficiency, although some side reactions were observed at higher PEG:hemoglobin ratios; the adduct bound oxygen with similar affinity and cooperativity as wild type hemoglobin. When directly compared to maleimide-PEG, the mono-sulfone-PEG adduct was significantly more stable when incubated at 37°C for seven days in the presence of 1 mM reduced glutathione. Hemoglobin treated with mono-sulfone-PEG retained &gt; 90% of its conjugation, whereas for maleimide-PEG &lt; 70% of the maleimide-PEG conjugate remained intact. Although maleimide-PEGylation is certainly stable enough for acute therapeutic use as an oxygen therapeutic, for pharmaceuticals intended for longer vascular retention (weeks-months), reagents such as mono-sulfone-PEG may be more appropriate.
Translation, Cultural Adaptation, and Reproducibility of the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+): The Brazilian Portuguese Version
Authors: Schwartz Juliano , Oh Paul , Takito Monica Y. , Saunders Bryan , Dolan Eimear , Franchini Emerson , Rhodes Ryan E. , Bredin Shannon S. D. , Coelho Josye P. , dos Santos Pedro , Mazzuco Melina , Warburton Darren E. R. 
Published: July 2021

Background: The Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) is the international standard for pre-participation risk stratification and screening. In order to provide a practical and valid screening tool to facilitate safe engagement in physical activity and fitness assessments for the Brazilian population, this study aimed to translate, culturally adapt, and verify the reproducibility of the evidence-based PAR-Q+ to the Brazilian Portuguese language.Method: Initially, the document was translated by two independent translators, before Brazilian experts in health and physical activity evaluated the translations and produced a common initial version. Next, two English native speakers, fluent in Brazilian Portuguese and accustomed to the local culture, back-translated the questionnaire. These back translations were assessed by the organization in charge of the PAR-Q+, then a final Brazilian version was approved. A total of 493 Brazilians between 5 and 93 yr (39.9 ± 25.4 yr), 59% female, with varying levels of health and physical activity, completed the questionnaire twice, in person or online, 1–2 weeks apart. Cronbach's alpha was used to calculate the internal consistency of all items of the questionnaire, and the Kappa statistic was used to assess the individual reproducibility of each item of the document. Additionally, the intraclass correlation coefficient and its 95% confidence interval (CI) were used to verify the general reproducibility (reliability) of the translated version.Results: The Brazilian version had an excellent internal consistency (0.993), with an almost perfect agreement in 93.8% of the questions, and a substantial agreement in the other 6.2%. The translated version also had a good to excellent total reproducibility (0.901, 95% CI: 0.887–0.914).Conclusion: The results show this translation is a valid and reliable screening tool, which may facilitate a larger number of Brazilians to start or increase physical activity participation in a safe manner.
A Protocol Study to Establish Psychological Outcomes From the Use of Wearables for Health and Fitness Monitoring
Authors: Folkvord Frans , van Breugel Amy , de Haan Sanneke , de Wolf Marcella , de Boer Marjolein , Abeele Mariek Vanden 
Published: July 2021

Background: The last few decades people have increasingly started to use technological tools for health and activity monitoring, such as tracking apps and wearables. The main assumption is that these tools are effective in reinforcing self-empowerment because they support better-informed lifestyle decision-making. However, experimental research assessing the effectiveness of the technological tools on such psychological outcomes is limited.Methods and Design: Three studies will be conducted. First, we will perform a systematic review to examine the experimental evidence on the effects of self-tracking apps on psychological outcome measurements. Second, we will conduct a longitudinal field experiment with a between subject design. Participants (N = 150) begin a 50-day exercise program, either with or without the aid of the self-tracking app Strava. Among those who use Strava, we vary between those who use all features and those who use a limited set of features. Participants complete questionnaires at baseline, at 10, 25, and 50 days, and provide details on what information has been tracked via the platform. Third, a subset of participants is interviewed to acquire additional qualitative data. The study will provide a rich set of data, enabling triangulation, and contextualization of the findings.Discussion: People increasingly engage in self-tracking whereby they use technological tools for health and activity monitoring, although the effects are still unknown. Considering the mixed results of the existing evidence, it is difficult to draw firm conclusions, showing more research is needed to develop a comprehensive understanding.Trial registration: Netherlands Trial registration: NL9402, received on 20 April 2021; https://www.trialregister.nl/trial/9402.
Causal Relationship Between Parathyroid Hormone and the Risk of Osteoarthritis: A Mendelian Randomization Study
Authors: Huang Guiwu , Zhong Yanlin , Li Wenchang , Liao Weiming , Wu Peihui 
Published: July 2021

BackgroundPrevious studies have demonstrated an inverse association between parathyroid hormone (PTH) and the risk of osteoarthritis (OA). However, it remains unknown whether such association reflects causality. We aimed to apply a Mendelian randomization (MR) approach to investigate the causal association between PTH and OA.Materials and MethodsWe performed a two-sample MR analysis using summary statistics from 13 cohorts (PTH, N = 29,155) and a recent genome-wide association study meta-analysis (OA, N = 455,221) by the UK Biobank and Arthritis Research UK OA Genetics (arcOGEN). MR analyses were carried out mainly using the inverse-variance-weighted method. Sensitivity analyses were performed to test the robustness of the associations using the weighted median method, the MR–Egger method, and “leave-one-out” analysis. Analyses were performed again to test whether the associations remained statistically significant after excluding any outlier variants that were detected using the MR-PRESSO (Mendelian Randomization Pleiotropy RESidual Sum and Outlier) test.ResultsFive single-nucleotide polymorphisms (SNPs) were selected as instrumental variables at the genome-wide significance threshold (p &lt; 5 × 10–8). The causal effect between PTH and OA was genetically predicted using the inverse-variance-weighted method (odds ratio = 0.67, 95% confidence interval: 0.50–0.90; p = 0.008). This result was borne out using the weighted median method (odds ratio = 0.73, 95% confidence interval: 0.60–0.90; p = 0.004). The causality remained robust after discarding the outlier variants as well as SNPs associated with confounding factors.ConclusionMR analysis supported a potential causative relationship between decreased serum circulating PTH and a higher risk of hip and knee OA.
ARG2, MAP4K5 and TSTA3 as Diagnostic Markers of Steroid-Induced Osteonecrosis of the Femoral Head and Their Correlation With Immune Infiltration
Authors: Yu Rongguo , Zhang Jiayu , Zhuo Youguang , Hong Xu , Ye Jie , Tang Susu , Liu Nannan , Zhang Yiyuan 
Published: July 2021

BackgroundThe diagnosis for steroid-induced osteonecrosis of the femoral head (SONFH) is hard to achieve at the early stage, which results in patients receiving ineffective treatment options and a poor prognosis for most cases. The present study aimed to find potential diagnostic markers of SONFH and analyze the effect exerted by infiltration of immune cells in this pathology.Materials and MethodsR software was adopted for identifying differentially expressed genes (DEGs) and conducting functional investigation based on the microarray dataset. Then we combined SVM-RFE, WGCNA, LASSO logistic regression, and random forest (RF) algorithms for screening the diagnostic markers of SONFH and further verification by qRT-PCR. The diagnostic values were assessed through receiver operating characteristic (ROC) curves. CIBERSORT was then adopted for assessing the infiltration of immune cells and the relationship of infiltration-related immune cells and diagnostic markers.ResultsWe identified 383 DEGs overall. This study found ARG2, MAP4K5, and TSTA3 (AUC = 0.980) to be diagnostic markers of SONFH. The results of qRT-PCR showed a statistically significant difference in all markers. Analysis of infiltration of immune cells indicated that neutrophils, activated dendritic cells and memory B cells were likely to show the relationship with SONFH occurrence and progress. Additionally, all diagnostic markers had different degrees of correlation with T cell follicular helper, neutrophils, memory B cells, and activated dendritic cells.ConclusionARG2, MAP4K5, and TSTA3 are potential diagnostic genes for SONFH, and infiltration of immune cells may critically impact SONFH occurrence and progression.
Differential Regulation of Damage-Associated Molecular Pattern Release in a Mouse Model of Skeletal Muscle Ischemia/Reperfusion Injury
Authors: Furubeppu Hiroaki , Ito Takashi , Kakuuchi Midori , Yasuda Tomotsugu , Kamikokuryo Chinatsu , Yamada Shingo , Maruyama Ikuro , Kakihana Yasuyuki 
Published: July 2021

BackgroundSkeletal muscle ischemia/reperfusion (I/R) injury is an important clinical issue that can cause remote organ injury. Although its pathogenesis has not been fully elucidated, recent studies have suggested that damage-associated molecular patterns (DAMPs) are mediators of remote organ injury in sterile inflammation. The purpose of this study was to investigate the possible involvement of DAMPs, including the nuclear proteins high-mobility group box 1 (HMGB1) and histone H3, in the pathogenesis of skeletal muscle I/R injury in mice.MethodsHindlimb ischemia was induced in mice through bilateral ligation of inguinal regions using rubber grommets. Reperfusion was induced by cutting the rubber grommets after 2–12 h of ischemic period. Survival rates, localization of HMGB1 and histone H3 in the gastrocnemius muscle, and circulating HMGB1 and histone H3 levels were analyzed. The effect of anti-HMGB1 and anti-histone H3 antibodies on survival was analyzed in mice with I/R injury.ResultsAll mice with hindlimb ischemia survived for at least 36 h, while all mice died within 24 h if the hindlimbs were reperfused after ischemia for 4–12 h. Immunohistochemical analysis revealed that HMGB1 translocated from the nucleus to the cytoplasm in the ischemic gastrocnemius muscle, while histone H3 was confined to the nucleus. Accordingly, serum HMGB1 levels were significantly elevated in mice with hindlimb I/R compared with normal mice or mice with hindlimb ischemia (P &lt; 0.05). Serum histone H3 levels were not elevated after I/R. Treatment with anti-HMGB1 antibodies significantly improved survival of mice with hindlimb I/R injury compared with control antibodies (P &lt; 0.05).ConclusionsHMGB1, but not histone H3, translocated to the cytoplasm during skeletal muscle ischemia, and was released into the systemic circulation after reperfusion in mice with I/R injury. Treatment with anti-HMGB1 antibodies partially improved survival.
Effect of Iron Tailings and Slag Powders on Workability and Mechanical Properties of Concrete
Authors: Ruidong Wu , Yu Shen , Juanhong Liu , Linian Cheng , Guangtian Zhang , Yueyue Zhang 
Published: July 2021

Tailings are one of the largest solid wastes in stock at present. In order to improve the comprehensive utilization rate of tailings, especially to solve the problems of fine-grained tailings treatment, the concrete composite admixture was prepared by using iron tailings powder and slag powder. In order to study the influence of iron tailings powder on the workability and long-term mechanical properties of concrete, C30 and C50 concrete with different iron tailings powder dosages were prepared, and the slump, expansion, flexural strength, splitting tensile strength, and compressive strength of concrete at different ages were tested. The results showed that the proper addition of iron tailing powder is beneficial to the working performance of concrete and can effectively reduce the time-loss of concrete fluidity. When the content of iron tailings powder in the composite admixture is 50%, the 1080d long age strength of C30 and C50 concrete can reach 50.3 and 80.7 MPa. Based on the 28d compressive strength, the relative strength-age prediction model of iron tailings powder concrete was established. The calculation and experimental results show that the model can accurately predict the compressive strength of micro-powder concrete of iron tailings at long age, and the error rate is less than 1%. The results lay a theoretical foundation for the utilization of iron tailings in concrete.