bluuebunny/crossref_metadata_2025_split huggingface dataset:
A chemically defined biomimetic surface for enhanced isolation efficiency of high-quality human mesenchymal stromal cells under xeno-/serum-free conditions
Authors: Thamm Kristina , Möbus Kristin , Towers Russell , Baertschi Stefan , Wetzel Richard , Wobus Manja , Segeletz Sandra 
Published: December 2021

AbstractMesenchymal stromal cells (MSCs) are one of the most frequently used cell types in regenerative medicine and cell therapy. Generating sufficient cell numbers for MSC-based therapies is constrained by: 1) their low abundance in tissues of origin, which imposes the need for significant ex vivo cell amplification, 2) donor-specific characteristics including MSC frequency/quality that decline with disease state and increasing age, 3) cellular senescence, which is promoted by extensive cell expansion and results in decreased therapeutic functionality. The final yield of a manufacturing process is therefore primarily determined by the applied isolation procedure and its efficiency in isolating therapeutically active cells from donor tissue. To date, MSCs are predominantly isolated using media supplemented with either serum or its derivatives, which pose safety and consistency issues. To overcome those limitations while enabling robust MSC production with constant high yield and quality, we developed a chemically defined biomimetic surface coating, called isoMATRIX, that facilitates the isolation of significantly higher numbers of MSCs in xeno-/serum-free and chemically defined conditions. The isolated cells display a smaller cell size and higher proliferation rate than those derived from a serum-containing isolation procedure and a strong immunomodulatory capacity. In sum, the isoMATRIX promotes enhanced xeno-, serum-free, or chemically defined isolation of human MSCs and supports consistent and reliable cell performance for improved stem cell-based therapies.
A simulation-based decision support tool for integrating site layout and construction planning of tunneling projects
Authors: RazaviAlavi SeyedReza , AbouRizk Simaan 
Published: December 2021

Purpose
Integrating construction and site layout planning in mechanized tunnel infrastructure projects is essential due to the mutual impacts of construction planning and site layout decisions. Simulation can incorporate site layout planning and construction planning of tunneling projects in a unified environment. However, simulation adoption by industry practitioners has remained relatively limited due to the special skills required for building and using simulation models. Therefore, this paper aims to create a simple-to-use simulation tool that supports site layout and construction operation planning of tunneling projects. This tool intends to promote the simulation application in site layout planning.

Design/methodology/approach
The current paper proposes simulation as a decision support tool (DST) to provide an integrated environment for modeling tunnel construction operations, site layout and capturing the mutual impacts. A special purpose simulation (SPS) tool was customized and developed for typical mechanized tunneling projects, by tunnel boring machines, to facilitate building the model and allow access to users with limited simulation knowledge.

Findings
The results show that the developed SPS tool is of great assistance to construction industry practitioners to analyze a variety of site layout and construction plan scenarios and make informed decisions based on its comprehensive and intuitive outputs.

Originality/value
The main contribution of this research is to promote simulation application in site layout planning of tunneling projects through the development of a simple-to-use tool, which has sufficient details for site layout planning and constraints. The developed DST enables planners to make decisions simultaneously on the site layout, other construction planning variables and identify the most efficient plan.
A rapid evidence assessment of psychological treatment approaches for stalking behaviour
Authors: Leigh Shonagh , Davies Jason 
Published: December 2021

PurposeThis paper aims to provide practitioners with a brief but comprehensive review of the current evidence base for psychological treatment approaches used in the UK that may be useful for stalking therapies.Design/methodology/approachA rapid evidence assessment was conducted on papers (post the UK Protection from Harassment Act, 1997) that discuss treatments of stalking (with or without a conviction) and associated offences/disorders. Therapies reviewed were Acceptance and Commitment Therapy, Cognitive Analytic Therapy, Cognitive Behavioural Therapy, Dialectical Behaviour Therapy and Schema Therapy. Searches for Mentalization-Based Therapy and Psychodynamic Therapy in relation to stalking were also performed but yielded no results that met inclusion criteria.FindingsThere is currently a severely limited evidence base for the efficacy of the psychological treatment of stalking behaviours. Some interventions show promise although a multifaceted, formulation-based approach is likely to be required.Practical implicationsFuture research would benefit from robust studies focused on stalking with long-term efficacy follow-ups.Originality/valueTo the best of the authors’ knowledge, this is the first rapid evidence review of psychological treatments that directly address stalking behaviour.
Self-efficacy is a story: teachers’ possible selves in a pandemic world
Authors: Narayanan Madhu , Ordynans Jill 
Published: December 2021

Purpose
A The purpose of this study was to better understand how teachers find agency in challenging circumstances. The authors sought to investigate this by examining the developing self-efficacy beliefs of teachers over time.

Design/methodology/approach
A longitudinal multi-case study methodology is used to investigate the stories of three new teachers over a two-year period spanning the onset of the pandemic. Narrative and thematic analysis was used to identify themes and trends. This was supplemented by teacher self-efficacy survey responses.

Findings
Teacher self-efficacy is a story that teachers build as they find what is possible. This story is informed by shifting conceptions of possible future selves as teachers interpret the challenges around them. These mutually reinforcing and fluid narratives shape teachers’ developing identities as they find agency during a changing reality.

Originality/value
Qualitative and case studies of self-efficacy are rare. Our study explores the context and thinking behind individual teacher beliefs at the time of a global pandemic. We offer a unique look at how teachers make sense of agency and possibilities under conditions of change.
Comparison of the usage of fines and PCC pigment in handsheets
Authors: Engin Merve 
Published: December 2021

PurposeThis paper aims to investigate the influences of fines and precipitated calcium carbonate (PCC) pigment and their contents on the fundamental properties of handsheets and also evaluate these results in terms of mechanical and chemical data.Design/methodology/approachA design research approach has been based on the production of various laboratory handmade papers. Any of the paper additives were not added to the paper web to compare the results of the effects of fines and PCC pigment in a literal way. For this purpose, the target grammages of handsheets and the production variables such as pulp consistency, temperature and other variables of formation, pressing and drying processes were kept constant and studied meticulously.FindingsThis study is confirmed that with the addition of fines to the pulp of the control handsheets, an increase of up to 125% has been observed in the tensile index values, while a decrease of up to 30% has been observed with the addition of PCC pigment as filler. The tensile results have been changed depending on the pulp content and hence chemical bonds formed in the paper web. These mechanical changes have been explained by correlating with the data of FT-IR spectrums. Especially, the variations have been seen at 950–1150 cm−1, which referring to C-OH and C-O-C stretching vibrations.Originality/valueThe originality of this work is based on understanding and comparing the effects of fines and the effect of PCC pigment as a paper filler on the structural and chemical characteristics of laboratory-made handsheets.
Development of a patient-specific immobilisation facemask for radiation therapy using additive manufacturing, pressure sensors and topology optimisation
Authors: Asfia Amirhossein , Novak James I. , Rolfe Bernard , Kron Tomas 
Published: December 2021

Purpose
Radiotherapy relies on the delivery of radiation to cancer cells with millimetre accuracy, and immobilisation of patients is essential to minimise unwanted damage to surrounding healthy cells due to patient movement. Traditional thermoformed face masks can be uncomfortable and stressful for patients and may not be accurately fitted. The purpose of this study was to use 3D scanning and additive manufacturing to digitise this workflow and improve patient comfort and treatment outcomes.

Design/methodology/approach
The head of a volunteer was scanned using an Artec Leo optical scanner (Artec, Luxembourg) and ANSYS (Ansys, Canonsburg, USA) software was used to make two 3D models of the mask: one with a nose bridge and one open as would be used with optical surface guidance. Data based on measurements from ten pressure sensors around the face was used to perform topology optimisation, with the best designs 3D printed using fused deposition modelling (FDM) and tested on the volunteer with embedded pressure sensors.

Findings
The two facemasks proved to be significantly different in terms of restricting head movement inside the masks. The optimised mask with a nose bridge effectively restricted head movement in roll and yaw orientations and exhibited minimal deformation as compared to the open mask design and the thermoformed mask.

Originality/value
The proposed workflow allows customisation of masks for radiotherapy immobilisation using additive manufacturing and topology optimisation based on collected pressure sensor data. In the future, sensors could be embedded in masks to provide real-time feedback to clinicians during treatment.
Toward belonging and mutual hospitality: decentering whiteness in the “new normal”
Authors: Hands Africa 
Published: December 2021

PurposeThe postquarantine reopening of public libraries presents an opportunity for resetting the way libraries welcome patrons. Unfortunately, vestiges of inhospitable, white supremacist practices experienced in public libraries may accompany the “return to normal.” In addition to emphasizing policies and practices that are unwelcoming to patrons and staff from historically marginalized backgrounds, this article presents actions to be employed in an effort to transition the library to a place of belonging and hospitality for marginalized staff and community members.Design/methodology/approachThis paper draws on a synthesis of the literature on hospitality in libraries and antiracism as well as the author's experience from professional practice to critique the host-and-guest concept of hospitality, which results in us versus them actions that uphold racism, white supremacy and white privilege.FindingsBarriers and institutional practices that negatively impact patrons and library workers are illuminated. Recommendations for creating an antiracist “new normal” in public libraries are proposed.Originality/valueIn addition to contributing to the literature on hospitality in libraries, this paper expands the capacity and knowledge base of library staff to call attention to and dismantle barriers and uninviting practices in their own libraries. The paper further advances mutual hospitality as a supplement to antiracism principles as libraries work to eradicate white supremacy.
Sex‐specific impact of major depressive disorder on 12‐year change in glycaemic status: Results from a nationwide cohort study of adults without diabetes in Germany
Authors: Nübel Julia , Truthmann Julia , Heidemann Christin , Du Yong , Paprott Rebecca , Hapke Ulfert , Kruse Johannes , Scheidt‐Nave Christa , Baumert Jens 
Published: December 2021

AbstractAimsThere is evidence for an increased type 2 diabetes (T2D) risk associated with depression, but its role for diabetes prevention remains unclear. This study aimed to add insight by investigating the impact of major depressive disorder (MDD) on prospective glycaemic changes.MethodsThe study was based on a cohort of n = 1,766 adults without diabetes (776 men, 990 women; 18–65 years of age) who participated in the mental health supplement of the German National Health Interview and Examination Survey (GNHIES98‐MHS, 1997–1999) and in a follow‐up survey (DEGS1, 2008–2011). Glycaemic status was defined as normoglycaemia [HbA1c < 39 mmol/mol (<5.7%)], prediabetes [39 ≤ HbA1c < 48 mmol/mol (5.7–6.4%)] and diabetes [HbA1c ≥ 48 mmol/mol (≥ 6.5%), diagnosed diabetes, or antidiabetic medication], and glycaemic changes categorized as ‘remission’, ‘stability’ and ‘progression’. Baseline MDD was assessed via a modified German version of the WHO Composite International Diagnostic Interview. Multivariable logistic regressions were applied to analyse the association of MDD with glycaemic changes and incident T2D, adjusting for socio‐demographics, lifestyle conditions, chronic diseases, antidepressant use and mental health care.ResultsMDD prevalence was 21.4% for women and 8.9% for men. Among women, MDD was associated with a lower chance for remission (RRR 0.43; 95% CI 0.23, 0.82). Among men, MDD was not significantly related to glycaemic changes. MDD had no significant effect on incident T2D (men: OR 1.58; 0.55, 4.52; women: OR 0.76; 0.37, 1.58).ConclusionsFindings of the current study highlight the role of depression in T2D prevention, particularly among women.
The macroeconomics of carry trade gone wrong: Corporate and consumer losses in Emerging Europe
Authors: Jakucionyte Egle , van Wijnbergen Sweder 
Published: December 2021

AbstractWe analyze the macroeconomic consequences of foreign currency losses by banks, corporates and consumers. To that end, we construct a New Keynesian DSGE model with debt overhang for corporate borrowers, monitoring costs for household mortgage debt and leverage constraints for banks. The Hungarian experience at the end of 2008 and model estimation on Hungarian data motivate these particular financial frictions. Model simulation shows that making corporate borrowers bear currency risk results in worse macroeconomic outcomes than currency mismatch losses on bank balance sheets. Foreign currency mortgages to households, however, generate lower output losses than currency mismatch in the banking sector. The fact that households do not suffer from debt overhang contributes to this result.
A novel scale to measure students’ perceptions of exemplars in a dental school
Authors: Rung Andrea , Hood Michelle , George Roy 
Published: December 2021

AbstractIntroductionExemplars are an effective strategy for initial cognitive and psychomotor skill acquisition and promoting students’ self‐regulation. Yet, there is limited evidence about students’ use and perception of exemplars in dental education. Therefore, this study aimed to develop a scale to measure students’ perception of exemplars in an Australian dental school.Materials and methodsPhase I assessed the relevant literature and students’ responses to an interview. Four themes were identified for developing a 19‐item questionnaire rated by an expert panel. Phase II piloted the questionnaire amongst a group of 30 students. Phase III analysed psychometric and qualitative open‐ended questions data obtained from a large group of students.ResultsThe principal axis factoring resulted in one single factor that explained over 62% of the variance and had an alpha of .88. The number of questions was reduced from 19 to 6 items with loadings of 0.72 or above for each item. Students reported exemplars are beneficial for their learning and to visually guide them to understand procedures and their intended outcomes. This prompts them to think and mentally prepare before performing. Students further reported using exemplars provided by their courses almost as often as exemplars they search in social media.ConclusionWell‐developed exemplars could play a key role in enhancing learning and could assist teaching. Understanding students’ use and perception of exemplars will help educators to develop and evaluate appealing exemplars. Therefore, this study developed a new instrument to measure students’ perception of exemplars, verified its reliability and validity.
Knowledge acquisition for 3D coordinates of target in wireless sensor networks for smart city application
Authors: Himanshu  , Khanna Rajesh , Kumar Anil 
Published: December 2021

AbstractIn wireless sensor networks, non‐linear distance information characterized by uncertainty and randomness creates the deviation and significantly target nodes position is affected. Non‐linearity effect among distance and received signal strength (RSS) of target nodes is minimized by modelling edge weights using knowledge base in fuzzy logic system. Further, optimum membership functions bases' of RSS and edge weights using application of butterfly optimization algorithm are evolved to minimize the node position error. Here, a single anchor node is used to estimate target nodes 3D coordinates in anisotropic environment using range free localization methods. The anchor node has been deployed at top layer and over beneath layers target nodes are distributed equally. In This paper, simulation results of the proposed method attain substantial performance improvement in target node 3D position accuracy than the earlier proposed range‐free methods. Proposed technique is useful for mapping of several instances like, fire hazards in forests, tracking of workers at different installation sites, solar plant tracking in smart cities and so forth.
Incidence and location of perioperative deep vein thrombosis in patients with bladder cancer undergoing radical cystectomy
Authors: Yamashita Ryo , Nakamura Masafumi , Okayama Yukiko , Kawase Mizuki , Muraoka Nao , Fujita Ayano , Notsu Akifumi , Asakura Koiku , Hashizume Akihito , Shinsaka Hideo , Matsuzaki Masato , Niwakawa Masashi , Oya Mototsugu 
Published: December 2021

ObjectivesTo determine the incidence and location of lower extremity deep vein thrombosis in patients undergoing radical cystectomy.MethodsWe performed radical cystectomy in 137 patients with bladder cancer between August 2014 and February 2020. Since 2014, we have had a policy to screen for deep vein thrombosis using lower extremity ultrasonography both before and after radical cystectomy. We determined the incidence and location of deep vein thrombosis and classified it as either proximal or distal type. Furthermore, we explored the incidence of pulmonary embolism within 3 months after radical cystectomy.ResultsAfter excluding six patients with a lack of ultrasonographic data, we evaluated 131 patients. Preoperative deep vein thrombosis (one proximal and 17 distal) was diagnosed in 18 patients (14%) with no symptoms. Postoperative deep vein thrombosis was diagnosed in 41 patients (31%; three proximal and 38 distal), of whom 26 (63%) had new‐onset deep vein thrombosis after cystectomy. Three patients, two with proximal and one with distal type deep vein thrombosis, developed nonfatal pulmonary embolism postoperatively. Multivariate analysis showed that preoperative D‐dimer levels (odds ratio 5.35, 95% confidence interval 1.74–16.50; P < 0.003), type of urinary diversion (ileal neobladder; odds ratio 11.15, 95% confidence interval 2.16–57.55; P = 0.004), and preoperative deep vein thrombosis (odds ratio 15.93, 95% confidence interval 3.82–66.30; P < 0.001) were significant risk factors for postoperative deep vein thrombosis.ConclusionsPre‐ and post‐radical cystectomy whole‐leg ultrasonography can lead to an early perioperative diagnosis and immediate treatment of proximal deep vein thrombosis, thereby potentially preventing fatal pulmonary embolism.
Teaching Children How to Think: Rational Autonomy as an Aim of Liberal Education
Authors: Franklin‐Hall Andrew 
Published: December 2021

ABSTRACTSome philosophers think that fostering children's autonomy – in the sense of critical, rational reflection on our beliefs and goals – is an appropriate aim of public educational policy. Critics say that this amounts to championing an Enlightenment outlook over ways of life rooted in faith and tradition. The most common response to the critics is to assert that children have an interest in autonomy, not because autonomy is intrinsically worthwhile, but because it is instrumentally valuable in discovering how to lead a good life. Finding fault with this Instrumental Argument, I argue that the best case for autonomy is that critical, rational reflection is something we all already rely on in everyday life to figure out which beliefs are worthy of our assent and which goals are worthy of our pursuit. The question is not whether children will reason, but whether they will reason well or poorly. Teaching children how to think critically is, thus, best understood as helping them meet their own emerging standards of rationality. And, given that we have a duty to respect others as reasoning beings, we in turn have a collective duty to foster young people's capacity to distinguish good reasoning from bad.
Young‐onset diabetes patients in Thailand: Data from Thai Type 1 Diabetes and Diabetes diagnosed Age before 30 years Registry, Care and Network (T1DDAR CN)
Authors: Dejkhamron Prapai , Santiprabhob Jeerunda , Likitmaskul Supawadee , Deerochanawong Chaicharn , Rawdaree Petch , Tharavanij Thipaporn , Reutrakul Sirimon , Kongkanka Chawkaew , Suprasongsin Chittiwat , Numbenjapon Nawaporn , Sahakitrungruang Taninee , Lertwattanarak Raweewan , Engkakul Pontipa , Sriwijitkamol Apiradee , Korwutthikulrangsri Manassawee , Leelawattana Rattana , Phimphilai Mattabhorn , Potisat Somkiat , Khananuraksa Panthep , Kunsuikmengrai Kemarasami , Nitiyanant Wannee ,   for the Thai Type 1 Diabetes and Diabetes diagnosed Age before 30 years Registry, Care and Network (T1DDAR CN)
Published: December 2021

ABSTRACTAims/IntroductionThere is a lack of current information regarding young‐onset diabetes in Thailand. Thus, the objectives of this study were to describe the types of diabetes, the clinical characteristics, the treatment regimens and achievement of glycemic control in Thai patients with young‐onset diabetes.Materials and MethodsData of 2,844 patients with diabetes onset before 30 years‐of‐age were retrospectively reviewed from a diabetes registry comprising 31 hospitals in Thailand. Gestational diabetes was excluded.ResultsBased on clinical criteria, type 1 diabetes was identified in 62.6% of patients, type 2 diabetes in 30.7%, neonatal diabetes in 0.8%, other monogenic diabetes in 1.7%, secondary diabetes in 3.0%, genetic syndromes associated with diabetes in 0.9% and other types of diabetes in 0.4%. Type 1 diabetes accounted for 72.3% of patients with age of onset <20 years. The proportion of type 2 diabetes was 61.0% of patients with age of onset from 20 to <30 years. Intensive insulin treatment was prescribed to 55.2% of type 1 diabetes patients. Oral antidiabetic agent alone was used in 50.8% of type 2 diabetes patients, whereas 44.1% received insulin treatment. Most monogenic diabetes, secondary diabetes and genetic syndromes associated with diabetes required insulin treatment. Achievement of glycemic control was identified in 12.4% of type 1 diabetes patients, 30% of type 2 diabetes patients, 36.4% of neonatal diabetes patients, 28.3% of other monogenic diabetes patients, 45.6% of secondary diabetes patients and 28% of genetic syndromes associated with diabetes patients.ConclusionIn this registry, type 1 diabetes remains the most common type and the prevalence of type 2 diabetes increases with age. The majority of patients did not achieve the glycemic target, especially type 1 diabetes patients.