bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the Dynamic Mechanical Properties of Metamorphic Limestone under Impact Loading
Authors: Zhang Zhiyu , Qian Qingyun , Wang Hao , Huang Yonghui , Wang Jianguo , Liu Haoshan 
Published: November 2021

Abstract
To study the dynamic damage and fracture of metamorphic limestone under explosive load and the stability of the surrounding rock, the stress-strain curve, fracture morphology, and energy dissipation characteristics of metamorphic limestone in the Dahongshan mining area under different strain rates were studied by the Hopkinson pressure bar (SHPB), stress wave analysis, and fractal theory. The experimental results show that the crushing form and degree are significantly affected by the loading strain rate. There are several typical failure modes. When the strain rate is 17.56 s−1, there is no obvious failure except corner cracks. When the strain rate is between 26.92 s−1 and 56.18 s−1, the failure mode of the specimen is axial splitting failure, and when the strain rate is 67.34 s−1, splitting and shearing failure occur. With the increase of the strain rate, the growth rate of the dynamic compressive strength slows down. Compared with static compressive strength, the strength factor increases from 1.15 to 4.19. Also, the fractal dimension shows a gentle increase. When Df is in the range of 1.82~2.24, there is a sudden change in fragmentation when the strain rate is in the range of 34.70 s−1~56.18 s−1. Energy dissipation density increases logarithmically with the strain rate. The results reveal the dynamic breaking and energy consumption laws of metamorphic limestone under impact loads with different strain rates and could provide some reference value for the safe and efficient construction in the Dahongshan mining area and similar engineering projects.
Expression of Sortilin in Pancreatic Carcinoma and Influence of Pancreatic Cancer Cells by Sortilin siRNA Knockdown
Authors: Xu Di , Yu Fan , Liu Shangqing , Rong Cai 
Published: November 2021

Abstract
BackgroundCurrently, there are few effective therapeutic options for pancreatic cancer patients. Sortilin is a member of vps10p receptor family，reported in many types of cancers. However, the underlying mechanism and prognostic value of sortilin in pancreatic cancer are still unclear. ObjectiveUnderstand the expression of sortilin in pancreatic cancer, and analyze its mechanism that affects the occurrence and development of pancreatic cancer. MethodsA tissue microarray of 115 pancreatic cancer metastases was analyzed by immunohistochemistry. All data were analyzed by univariate analysis and multivariate analysis. Multivariate logistic regression analysis and the area under the receiver operating characteristic (ROC) curve were used to analyze the ability of sortilin in predicting pancreatic cancer. Next, survival analysis was performed to compare the survival time between high-risk and low-risk patients to validate the prognosis prediction efficacy of sortilin. The effects of sortilin on the invasion，metastasis and proliferation of pancreatic cancer cells were investigated both in vitro. investigate the anti-cancer effect of soritlin on human pancreatic cancer Capna1 and Bxpc3 cells, and its possible molecular mechanism. ResultsDifferential expression analysis of 115 tissue microarrays showed sortilin expression was up‐regulated in pancreatic cancer tissues,and it mainly comes from the nucleus. Sortilin expression in nucleus(SEIN) was only negatively correlated with N stage, Binary logistic regression model showed that SEIN is a good diagnostic marker for predicting pancreatic cancer and the accuracy of prediction is as high as 79.1 %. ROC curve analysis demonstrated a statistically significant diagnostic value of SEIN,and the diagnostic accuracy was 86.3%, The Youden Index was calculated to evaluate the diagnostic power, The cut-off value for SEIN in pancreatic cancer diagnosis was 0.85, with a sensitivity of 90.9% and a specificity of 68.3%. Univariate analysis showed that M stage(P=0.022), histological grade(P=0.021), clinic stage(P=0.030)and SEIN(P=0.039) were correlated with prognosis of pancreatic cancer patients, Multivariate regression analysis showed that M stage(P=0.036)and ESIN(P=0.004) were independent factors.The proliferation, invasion and migration of pancreatic cancer cells were inhibited in vitro by sortilin siRNA knockdown.it may have something to do with soritlin/P53/NFκB regulated the the proliferation function and sortilin/MMP9 regulated the invasion-promotion of pancreatic cancer cells. Conclusions﻿These fndings demonstrated that the low expression of SEIN indicates better prognosis in pancreatic cancer and supplemented the effect mechanism of sortilin on pancreatic cancer cells. SEIN expression may serve as a potential diagnostic indicator of pancreatic cancer.
Incidence And Risk Factor Analysis For Swelling After Apical Microsurgery
Authors: Bi Cheng , Xia Siqi , Zhu Yuchi , Lian Xinzhu , Hu Lijun , Rao Chenxing , Jin Haibin , Shang Xiaodan , Jin Feifan , Li Jingyu , Zheng Pei , Wang Shuhua 
Published: November 2021

Abstract
The aim of this prospective observational cohort study is to evaluate developing periapical swelling after apical microsurgery and determine potential risk factors. Ninety-eight apical microsurgery patients were selected for this study. Before surgery, bone shadow volume and density of pathological tissue were measured by CBCT. The other variables (age, gender, operative teeth number, fistula, preoperative swelling, drug use and pre-surgery root canal treatments) were assessed during examination. Swelling degree was confirmed by questionnaires for patients on the 1st, 7th, 14th, and 21st days respectively after surgery. Statistical analyses were performed to identify predictors for swelling. Majority of patients reported moderate (45.9%) or severe (34.7%) swelling on day 1, and moderate (44.9%) or mild (45.9%) on day 7. 99% patients had no or mild swelling on day 14. The average swelling level peaked on day 1 postoperatively and gradually decreased. Of statistical significance, age, bone shadow volume and density of pathological tissue acted as predictors of swelling(P<0.05). However, there was no significant difference in gender, tooth number, fistula, preoperative swelling, drug use, or pre-surgery root canal treatments (P > 0.05). We conclude that younger patients with larger shadow volume and density were significantly more likely to develop swelling after apical microsurgery.
Distinct Expression Pattern and Prognostic Values of E2F Family Genes in Lung Adenocarcinoma and Squamous Cell Carcinoma
Authors: Wang Shuo , Zhang Jun , Meng Fan-Jie , Yan Yi-Jie , Wang Bin , Guan Zhi-Yu 
Published: November 2021

Abstract
The E2F transcription factors family included E2F1-8 playing the crucial roles in the origination and progression of various kinds of human cancers. However, a comprehensive analysis regarding the gene mRNA expression pattern at bulk and single-cell resolution, the prognostic values and the association to immune cell infiltration of E2F family genes in lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) remains to be performed. The bulk and single-cell mRNA expression levels of E2F family members in LUAD and LUSC were determined using the cBioPortal, Gepia, TISCH and Oncomine online databases. Based on the differentially expressed genes, GO enrichment and GSEA items were investigated. The Kaplan‑Meier plotter server was used to evaluate the prognostic significances of the E2F family genes in patients with LUAD and LUSC based on the related clinicopathological features. The correlation between E2F family gene expression and immune cell infiltration was explored using the Timer database. Our bulk and single-cell RNA analyses revealed that E2F1, E2F2 and E2F8 might promote the tumor growth and aggressiveness of LUAD and LUSC indicating the poor prognosis prediction. E2F4 and E2F6 might be considered as the potential outcome markers for the improved treatment of LUAD and LUSC, respectively. Upregulation of E2F1 and E2F8 indicated the poor prognosis of LUAD patients, whereas only E2F2 overexpression was associated with shorter overall survival of LUSC patients. There existed a positive relationship between E2F8 expression level and infiltration level of macrophages and DCs, and significantly positive correlation between infiltration level of CD8+ T, CD4+ T cells and E2F1/2/7 expression in LUAD and LUSC. In conclusion, our findings suggested that increased expression of E2F1/E2F8 or E2F2 may serve as promising prognostic biomarkers for patients with LUAD or LUSC, respectively.
Location Prediction with Personalized Federated Learning
Authors: wang shuang , Wang Bowei , Yao Shuai , Qu Jiangqin , Pan Yuezheng 
Published: November 2021

Abstract
Location prediction has attracted wide attention in human mobility prediction because of the popularity of location-based social networks. Existing location prediction methods have achieved remarkable development in centrally stored datasets. However, these datasets contain privacy data about user behaviors and may cause privacy issues. A location prediction method is proposed in our work to predict human movement behavior using federated learning techniques in which the data is stored in different clients and different clients cooperate to train to extract useful users’ behavior information and prevent the disclosure of privacy. Firstly, we put forward an innovative spatial-temporal location prediction framework(STLPF) for location prediction by integrating spatial-temporal information in local and global views on each client, and propose a new loss function to optimize the model. Secondly, we design a new personalized federated learning framework in which clients can cooperatively train their personalized models in the absence of a global model. Finally, the numerous experimental results on check-in datasets further show that our privacy-protected method is superior and more effective than various baseline approaches.
Infection of West African Dwarf Rams With Trypanosoma Brucei Brucei and Trypanosoma Congolense Significantly Alter Serum Electrolytes, Redox Balance, Sperm Parameters, And Gonadal Morphology
Authors: Anyogu Davinson Chuka , Shoyinka Shodeinde Vincent O. , Ihedioha John Ikechukwu 
Published: November 2021

Abstract
Trypanotolerance of the West African dwarf (WAD) breeds may not rule out significant pathophysiological changes that may affect productivity. In this study, the effects of infection of WAD rams with Trypanosoma brucei brucei (Tbb) and Trypanosoma congolense (Tc) on their serum levels of electrolytes [calcium, phosphorus, sodium, potassium]; oxidative stress markers [superoxide dismutase (SOD), malondialdehyde (MDA)]; and sperm parameters [sperm count, motility, vitality, and morphology] were investigated. Fifteen WAD rams, assigned to 3 groups (A, B & C) of 5 rams each, were used for the study. Group A rams were infected with Tbb, while Group B rams were infected with Tc, both intraperitoneally, at the dose of 106 trypanosomes/animal. Group C rams served as the uninfected control. The infections were monitored for 70 days. Serum calcium levels were significantly (p < 0.05) lower in Tbb and Tc infected rams compared to the control throughout the study. Serum sodium was significantly (p < 0.05) higher in the Tb infected rams compared to the Tc infected and control rams on days 14 and 28 PI. Serum SOD activity decreased while MDA levels increased in both infected groups of rams. Tbb infected rams were azoospermic, while Tc infected rams had lower sperm motility, vitality and concentration and higher number of abnormal sperm cells compared to the control. Necrotic and inflammatory lesions occurred in the testis and epididymis of both infected rams. These results suggest that in spite of trypanotolerance, trypanosome infections in the WAD rams significantly impact on health and reproduction.
10-Hz tACS Over The Prefrontal Cortex Improves Phonemic Fluency
Authors: Sun Ya , Hua Qiaoling , Huang Lihui , Liu Qiang 
Published: November 2021

Abstract
Verbal fluency is an important indicator of human verbal ability. Methods to improve fluency is an interesting issue necessitating investigation. To do this, the current study required participants to randomly receive transcranial alternating current stimulation (tACS) at 10 Hz, 40 Hz (control frequency), and sham stimulation over the prefrontal cortex before a phonemic fluency task. It was found that 10-Hz tACS significantly improved phonemic fluency relative to sham stimulation. This result demonstrates the modulatory effect of 10-Hz tACS on language ability.
A Qualitative Assessment of Gender Roles and Implications for Child Nutrition in Central Malawi
Authors: Mkandawire Elizabeth , Bisai Clement , Dyke Elizabeth , Dressel Anne , Kantayeni Hazel , Molosoni Billy , Kako Peninnah M , Gondwe Kaboni , Mkandawire-Valhmu Lucy 
Published: November 2021

Abstract
Child malnutrition persists globally. While progress in reducing stunting has been witnessed over the last six years, this progress is not sufficient to meet Sustainable Development Goal targets on stunting. In Africa, child malnutrition is estimated to result in between 1.6 to 16% losses in gross domestic product. Undernutrition is also attributed as a cause of death for 11% of African children aged five years and below. Men and women play distinct roles in supporting a child's nutrition. Women frequently carry the bulk of the workload related to food, care, and health, all of which are critical factors in child nutrition. Using focus group discussions and individual interviews with communities in rural Central Malawi, we sought to understand the roles played by men and women in achieving child nutrition in this qualitative study. We found that both men and women were involved in productive, reproductive, and community work. However, consistent with the literature, women carried a disproportionate workload in supporting child nutrition compared to men. Women's heavier workloads often prevented them from being able to meet children's food needs. Nevertheless, shifts in gender roles were observed in some of the sampled communities, with men taking up responsibilities that have been typically associated with women. This undoing of gender roles did not necessarily increase women's power within the household. Improving gender equality and child nutrition will require efforts to redistribute gendered work and encourage men to move towards shared power over household decision-making and control over income with women.
Effective Mathematical Modelling of Health Passes During a Pandemic
Authors: Hohenegger Stefan , Cacciapaglia Giacomo , Sannino Francesco 
Published: November 2021

Abstract
We study the impact on the epidemiological dynamics of a class of restrictive measures that are aimed at reducing the number of contacts of individuals who have a higher risk of being infected with a transmittable disease. Such measures are currently either implemented or at least discussed in numerous countries worldwide to ward off a potential new wave of COVID-19. They come in the form of Health Passes (HP), which grant full access to public life only to individuals with a certificate that proves that they have either been fully vaccinated, have recovered from a previous infection or have recently tested negative to SARS-Cov-2. We develop both a compartmental model as well as an epidemic Renormalisation Group approach, which is capable of describing the dynamics over a longer period of time, notably an entire epidemiological wave. Introducing different versions of HPs in this model, we are capable of providing quantitative estimates on the effectiveness of the underlying measures as a function of the fraction of the population that is vaccinated and the vaccination rate. We apply our models to the latest COVID-19 wave in several European countries, notably Germany and Austria, which validate our theoretical findings.
Coexistence of Craniopharyngioma and Cranial Fibrous Dysplasia: A Clinicopathological Study of 5 Cases and Literature Review
Authors: Fan Yang-Hua , LI ZHI 
Published: November 2021

Abstract
Background: Craniopharyngioma (CP) and cranial fibrous dysplasia (CFD) are both rare embryonic benign cranial diseases that most commonly present during childhood or adolescence. Co-existence of CP and CFD is extremely rare, which has never been reported before.Methods: We retrospectively reviewed the data of 5 patients coexisted with CP and CFD in Beijing Tiantan Hospital from January 2003 to January 2021. Their clinicopathological features, treatment modalities, and outcomes were summarized. Moreover, a comprehensive literature review was conducted, and in order to explore the potential connection leading to this coexistence, the CFD characteristic GNAS gene and corresponding Gsα protein were tested in the CPResults: There were 4 males and 1 female (median age, 39 years) in the present series. The symptoms mainly included headache, dizziness, fatigue, polyuria/polydipsia, hypogonadism and blurred vision. Sphenoidal bone is the most common involved bone by CFD (n =4). Four patients had undergone surgery to remove the CP (1 transsphnoid and 3 transcranial). Complete and subtotal resection were achieved in 2 cases respectively. The tumor subtypes were 3 adamantinomatous, 1 unknown subtype. The common postoperative complications are pan-hypopituitarism, diabetes insipidus, and hypothyroidism. The mean follow-up time was 57.2 months. Postoperative hormone replacement was required in 2 patients. 3 patients underwent a genetic study of tumor specimens. GNAS mutations were not detected, but they were positive for Gsα protein. Conclusions: Though the definite causative relationship has not been proved, the coexistence of CP and CFD should not completely be excluded potential interplay or atypical FD course for the uncommon manifestations of CPs. Prompt diagnosis and appropriate treatment are more challenging than for solitary CPs for the deformations of skull base, as of now, management strategies are aimed at surgical treating the CP and regularly monitoring the CFD.
Establishment of a Finite Element Model of Supination-external Rotation Ankle Joint Injury and Analysis of Mechanical Changes in the Posterior Malleolar Surface
Authors: Zhang Xin , Xie Pinliang , Shao Weirong , Xu Ming , Xu Xiaoping , Yin Yong , Fei Lan 
Published: November 2021

Abstract
BackgroundBy establishing a three-dimensional finite element model of supination and external rotation ankle injury, the stress characteristics of the posterior ankle joint surface can be obtained, and complete analysis of the corresponding stress on the lateral ankle can be examined. MethodsThin-layer computed tomography (CT) images of normal ankle joints in the supination and external rotation non-weight-bearing states were selected, a three-dimensional data model of each ankle joint, including the ligament, was established, and whether different degrees of injury were coexistent with lateral ankle fracture was analysed by the finite element method. A load was applied to examine different ankle joint stress values and pressure distributions on the surface of the posterior ankle joint. ResultsWhen a load was applied, the maximum stress was located at the point of attachment of the anterior tibiofibular ligament to the tibia. When the anterior tibiofibular ligament was removed and the lateral malleolus was intact, the maximum stress (271.2 MPa) was located at the attachment point of the posterior tibiofibular ligament to the tibia, and the maximum pressure of the posterior ankle joint surface was 2.626 MPa. When a lateral malleolus fracture was present and the same load was applied, the maximum stress (82 MPa) was located on the fibular fracture surface, and the maximum pressure of the posterior ankle joint surface was 7.787 MPa. The posterior tibiofibular ligament was then removed completely from the lateral malleolus, and the maximum stress (132.7 MPa) was located at the point of attachment of the posterior tibiofibular ligament to the fibula, and the maximum pressure of the posterior ankle joint surface was 4.505 MPa. When a lateral malleolar fracture was present, the maximum stress (82.72 MPa) was located on the fibular fracture surface, and the maximum pressure of the posterior ankle joint surface was 8.022 MPa. ConclusionThis study shows that reconstruction of the lateral malleolus in supination-external rotation ankle injury significantly affects the stress distribution at the posterior malleolar joint surface. When reconstruction of the lateral malleolus is complete, the pressure distribution of the posterior malleolar joint surface can be significantly reduced. The results highlight the significance of reconstruction of posterior malleolar fractures and posterior tibiofibular ligament stability.
Host Landing And Diel Activity of Potent Vectors of Bluetongue Disease, Culicoides Oxystoma and Culicoides Peregrinus
Authors: Mazumdar Shuddhasattwa Maitra , Mandal Biswajit , Kar Surajit , Mazumdar Abhijit 
Published: November 2021

Abstract
Background The spread of bluetongue virus depends on the vectorial ability of Culicoides affecting the susceptible host. Animal farms in West Bengal have reported prevalence of potent vectors of BTV (C. oxystoma, C. peregrinus and C. fulvus). Besides, high seroprevalence of BTV was also reported from this cattle dense region. Henceforth host-seeking activity of two important potent vectors, C. oxystoma and C. peregrinus on cattle were studied in two farm sites of West Bengal, India.Methods The study was done in 2018-19 comprising of total 297 hours of collection over 27 nights. A comparison was made between the catches obtained by mouth aspirator and light trap. Hourly collections of Culicoides were done directly from cattle (oral aspirator) as well as light trap was operated in close vicinity of cattle at a different shed.Results A total of 11,462 Culicoides belonging to C. oxystoma, C. peregrinus and C. fulvus were collected in light trap and aspirator. In aspirator 4764 midges were collected whereas 6698 individuals were collected in light trap. The following species were aspirated: C. peregrinus and C. oxystoma; however the light trap catches consisted of C. fulvus, C. oxystoma and C. peregrinus. Light trap collection exhibited crepuscular activity whereas aspirator collection was maximum between 4.00 am and 5.00 am. Likewise maximum landing of midges was observed in neck and hump region of cattle.Conclusion It was observed that the preferred time of feeding of C. peregrinus and C. oxystoma on cattle were early morning hours though midges were ubiquitous from dusk to dawn. Surprisingly the preferential landing of the two vectors were mostly restricted to the neck and hump region of the cattle. The results obtained during the study warrants further insight into the factors influencing the landing site by the vectors which may be useful biological data in disease management and draw effective deterrent strategies.