bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life in a randomized phase II study to determine the optimal dose of 3-week cycle nab-paclitaxel in patients with metastatic breast cancer
Authors: Taira Naruto , Kashiwabara Kosuke , Tsurutani Junji , Kitada Masahiro , Takahashi Masato , Kato Hiroaki , Kikawa Yuichiro , Sakata Eiko , Naito Yoichi , Hasegawa Yoshie , Saito Tsuyoshi , Iwasa Tsutomu , Takashima Tsutomu , Aihara Tomohiko , Mukai Hirofumi , Hara Fumikata 
Published: May 2021

Abstract
Background
To report our findings on quality of life (QoL) in a randomized phase II study to determine the optimal dose of 3-week cycle nab-paclitaxel (q3w nab-PTX) in patients with metastatic breast cancer (MBC).
Methods
Patients with HER2-negative MBC were randomly assigned to three different doses of q3w nab-PTX (SD: 260 mg/m2 vs. MD: 220 mg/m2 vs. LD: 180 mg/m2). QoL was assessed at baseline and during the 2nd, 4th and 6th courses of treatment using the Functional Assessment of Cancer Therapy-Taxane (FACT-Taxane), Cancer Fatigue Scale (CFS) and EuroQol 5-Dimension (EQ-5D). Comparisons were performed with mixed-model repeated-measures (MMRM).
Results
A total of 141 patients were enrolled in the parent study, and 136 (96%) (44, 45 and 47 in the SD, MD, and LD groups) were included in the analysis. MMRM analysis showed that the difference from the baseline FACT-Taxane trial outcome index at MD and LD were significantly higher than that at SD (MD vs. SD P < 0.001, LD vs. SD P < 0.001). Differences from baseline for FACT-Taxane total, physical and emotional well-being, and taxane subscale scores at MD and LD were also higher than at SD. The difference from baseline for the CFS score at LD was lower than at SD (P = 0.013) and those for EQ-5D utility scores at MD and LD were higher than at SD (MD vs. SD P = 0.011, LD vs. SD P < 0.001).
Conclusion
QoL of patients treated with 220 or 180 mg/m2 of q3w nab-PTX was significantly better than that of patients treated with 260mg/m2.
Trial registration:
The protocol was registered at the website of the University Hospital Medical Information Network (UMIN), Japan (protocol ID: UMIN000015516), on 01/11/2014. Details are available at the following address:
Experiment Regarding Magnetic Fields with Gravity
Authors: Lee Jong-hoon 
Published: May 2021

Abstract
The ground-based device simulates the potential energy (voltages) between gravity and magnetic seas. The gravity generator (GG) generated currents and voltages on the mesoscopic scale in the vacuum. Gravity interacts to generate electricity in the Earth's direction or the opposite direction by the repulsive magnetic force. A trapped gravity was set to behave as free relativistic quantum particles or fluids, which made it possible to measure the particle position as a function of time. Our result is grounded on a rigorous proof based on numerical and analytic computations, which took it accessible to study the magnetic sea for different initial superposition of positive- negative-gravity spinor state. It might explain the relativistic quantum gravity and the heating mechanism of the Sun.
Association between MTHFR C677T polymorphism and the susceptibility to nonsyndromic cleft lip with or without cleft palate in Chinese Han population: a case-control study and meta-analysis
Authors: Lu Xuemei , Deng Xiaoling , Liu Tingying , Zhang Qiufang , Xu Mingyan 
Published: May 2021

Abstract
Background: Functional polymorphisms on methylenetetrahydrofolate reductase (MTHFR) gene are reported to be involved in the etiology of nonsyndromic cleft lip with or without cleft palate (NSCL/P), but the conclusions are still inconsistent. The aim of our study is to investigate the association between the susceptibility of nonsyndromic cleft lip with or without cleft palate (NSCL/P) and MTHFR C677T polymorphism in Chinese Han population．Methods: A case-control study was performed, followed by a Meta-analysis. Electronic databases including PubMed, Embase, CNKI, VIP and Wanfang database were searched for relevant literature from inception of databases to November 2020. Meta-analysis was performed using Revman 5.3 and STATA 12.0 software. Results: The case-control study included 358 NSCL/P cases and 354 controls, which indicated that the variant T allele significantly increased NSCL/P risk in Southern China. Then, in the present Meta-analysis, a total of nine case-control studies with 1444 cases and 1555 controls were included. Overall, there was a significant association between MTHFR C677T polymorphism and NSCL/P susceptibility under all genetic models. The subgroup analysis of NSCL/P types showed significantly increased risk of CLO but not CPO or CLP. In terms of the stratified analysis by geographical location, a significantly association was observed in Southern China under all genetic models, while there was no significant association in Northern China. Sensitivity analyses, Begg's funnel plot and Egger’s regression test further suggest the stable and trustworthy of these results. Conclusion: MTHFR C677T polymorphism is associated with the risk of NSCL/P in Chinese Han population, especially increasing the risk of NSCL/P in southern Chinese Han populations.
Predicting LQ45 Financial Sector Indices using RNN-LSTM
Authors: Hansun Seng , Young Julio Christian 
Published: May 2021

Abstract
As one of the most popular financial market instruments, the stock has formed one of the most massive and complex financial markets in the world. It could handle millions of transactions within a short period and highly unpredictable. In this study, we aim to implement a famous Deep Learning method, namely the Long Short-Term Memory (LSTM) networks, for the stock price prediction. We limit the stocks to those that are included in the LQ45 financial sectors indices, i.e., BBCA, BBNI, BBRI, BBTN, BMRI, and BTPS. We propose to use a simple three layers LSTM network architecture in predicting the stocks’ closing prices and found that the prediction results fall in the reasonable forecasting category. It is worthy to note that two of the considered stocks, i.e., BBCA and BMRI, have the lowest MAPE values at 19.1020 and 18.6135 which fall in the good forecasting results. Hence, the proposed LSTM model is recommended to be used on those two stocks.
Influence of The Expression Vector And of Its Elements On Recombinant hPRL Bacterial Synthesis: The Co-Directional Orientation of Replication And Transcription is Highly Critical
Authors: Affonso Regina , Suzuki Miriam Fussae , Magalhães Geraldo Santana , Bartolini Paolo 
Published: May 2021

Abstract
The aim of the present work was to define a bacterial expression system that is particularly efficient for the synthesis of human prolactin (hPRL). In previous work, the synthesis of rec-hPRL by the p1813-hPRL vector in E. coli HB2151 was >500 mg/L, while it was much lower now (2.5-4-fold), in the strains RB791 and RRI. The highest positive influence on rec-hPRL synthesis was due to the transcription-replication co-orientation of hPRL cDNA and the ori/antibiotic resistance gene, responsible for up to a ~5-6-fold higher expression yield. In conclusion, this work confirmed that each bacterial strain of E. coli has a genetic set that can allow a different level of heterologous protein synthesis. The individual study of each element indicated that its action critically depends on the reading orientation in which it is located inside the vector: co-directional orientation of replication and transcription, in fact, greatly increased the level of rec-hPRL expression.
Study of teenage students’ musculoskeletal health, teenage students training program: the application of intervention mapping approach to Develop Implementation Strategies
Authors: NeJhaddadgar Nazila , Tavafian Sedigheh Sadat , ziapour arash , Abbas Jaffar , Jamshidi Ahmad Rreza 
Published: May 2021

Abstract
Background: According to the studies conducted, teenage and its related health issues are of the most significant issues. The purpose of the study was to develop a Musculoskeletal Health intervention-training program using intervention mapping approach (IMA)for teenagers 12 to 14 years old.Methods: The present study is a study protocol where IMA has been used as a planning framework for developing musculoskeletal Health intervention-training program. Six intervention mapping steps have been completed in the study. As the first step, needs assessment has been performed by systematic review and qualitative evaluation . In the second step, matrix of change objectives was designed. Later on, after designing the program and planning the program implementation, the program evaluation plan was developed.Results: IMA guided us in designing and implementing a control-oriented training program with the participation of the participants along with the definition of outcomes, performance goals and determinants, theoretical methods and practical applications, intervention program, implementation and step by step assessment.Conclusion: Intervention mapping is a participation-based approach to design and implement promotion programs.
Tunable Multi-Frequency Optoelectronic Oscillator Based on a Microwave Photonic Filter and an Electrical Filter
Authors: Zhang Jin , Wang Yalan , Li Xiang , Liu Zhuangzhuang , Wo Jianghai 
Published: May 2021

Abstract
We propose and experimentally demonstrate a multi-frequency optoelectronic oscillator (OEO) based on phase-modulation to intensity-modulation (PM-IM) conversion. A microwave photonic filter (MPF) incorporating an optical fiber Bragg grating Fabry-Perot (FBG-FP) filter and an electrical yttrium iron garnet (YIG) filter in two branches are used to select the oscillation modes of the OEO. By adjusting the wavelength of laser source or the central frequency of YIG filter, two frequencies can be tuned independently within a wide range. The single sideband (SSB) phase noises of the generated frequencies are measured experimentally. Moreover, the OEO shows potential ability to achieve more frequencies oscillation by multiplexing more optical and electrical filters.
New Classification Based on CT and Its Value Evaluation for Fractures of the Lateral Process of the Talus
Authors: Wang Yuchuan , Deng Xiangtian , Zhu Yanbin , Wang Zhongzheng , Fu Lei , Chen Wei , Zhang Yingze 
Published: May 2021

Abstract
Background : The common classifications of the fractures of the lateral process of the talus（LTPFs）are based on radiographs and may underestimate the complexity of LTPF, therefore. The aim of this study was to propose a comprehensive CT-based classification system, and to evaluate its prognostic value, reliability and reproducibility.Material and Methods: We retrospectively reviewed 42 patients involving LTPF and clinical and radiographic evaluations were performed at an average follow-up of 35.9 months. In order to create a comprehensive classification, a panel of experienced orthopedic surgeons discussed the cases. All fractures were classified according to Hawkins, McCrory-Bladin and new proposed classification system by four surgeons. The analysis of interobserver and intraobserver agreements was done using kappa statistics.Results: This new classification included two types based on presence of concomitant injuries or not, with type I consisting of three subtypes and type II of five subtypes. Average AOFAS score was 91.5 in the type Ia of new classification proposed, 86 in type Ib, 90.5 in type Ic, 89 in type IIa, 76.7 in type IIb, 76.6 in type IIc, 91.3 in type IId, and 83.5 in type IIe. Interobserver and intraobserver reliability of the new classification system were almost perfect (κ=0.846 and 0.823, respectively)，showing a higher interobserver and intraobserver reliability compared to the Hawkins classification (κ=0.737 and 0.689, respectively) as well as McCrory-Bladin classification (κ=0.748 and 0.714, respectively). Conclusion: The new classification system is a comprehensive one that takes into account concomitant injuries and it shows good prognostic value with clinical outcomes. It is more reliable and reproducible and could be a useful tool for decision-making on treatment options for LTPFs.
Recurrent transperineal aggressive angiomyxoma: a case report
Authors: Li Xiaoli , Zhou Chunxia , Lin Jun 
Published: May 2021

Abstract
Background: aggressive angiomyxoma is a rare disease that may cause misdiagnosed in the clinical work and the characteristic of this disease is low potential malignancy. This case show a recurrent case of aggressive angiomyxoma 7 years after the surgery which was mistakenly diagnosed at that time.Case presentation: the patient presented a large mass in the right labium majus without any pain. This mass was recurrent 7 years after she received a surgery about the mass occurred at the same place which was diagnosed as vulvar angiomyofibroblastoma. She took the ultrasound scan and MRI scan and underwent the surgery again. This mass was excision completely. At this time, pathologist checked the HE stained slides and immunohistochemistry staining slides, then come the conclusion that this mass was aggressive angiomyxoma. We rechecked the pathological slides 7 tears ago and found out it was misdiagnosed at that time.Conclusions: Aggressive angiomyxoma is a rare tumor. This case presents a rare disease that may be misdiagnosed as other benign vulvar disease even after the surgery which get pathologic evidence. So we need to know more abou this disease.
Honey Bees Extract Map Coordinates from the Dance
Authors: Wang Zhengwei , Chen Xiuxian , Becker Frank , Greggers Uwe , Walter Stefan , Werner Marleen , Gallistel Charles , Menzel Randolf 
Published: May 2021

Abstract
Honeybees communicate locations by the waggle dance, a symbolic form of information transfer. Here we ask whether the recruited bee uses only the indicated course vector or translates it into a location vector on a cognitive map. Recruits were captured on exiting the hive and displaced to distant release sites. Their flights were tracked by radar. Both the vector portions of their flights and the ensuing tortuous search portions were strongly and differentially affected by release site. Search patterns were biased toward the true location of the food and away from the location given by adding release-site displacement to the danced vector. The results imply that the bees recruited by the dance access the indicated location of the food on a shared spatial representation. Thus, the bee dance communicates two messages, a flying instruction and a map location.
Thermodynamics of Ideal Gas at Planck Scale with Strong Quantum Gravity Measurement
Authors: Lawson Latevi Mohamed 
Published: May 2021

Abstract
More recently in J. Phys. A: Math. Theor. 53, 115303 (2020), we have introduced a set of noncommutative algebra that describes the space-time at the Planck scale. The interesting significant result we found is that the generalized uncertainty principle induced a maximal length of quantum gravity which has different physical implications to the one of generalized uncertainty principle with minimal length. The emergence of a maximal length in this theory revealed strong quantum gravitational effects at this scale and predicted the detection of gravity particles with low energies. To make evidence of these predictions, we study the dynamics of a free particle confined in an infinite square well potential in one dimension of this space. Since the effects of quantum gravity are strong in this space, we show that the energy spectrum of this system is weakly proportional to the ordinary one of quantum mechanics free of the theory of gravity. The states of this particle exhibit proprieties similar to the standard coherent states which are consequences of quantum fluctuation at this scale. Then, with the spectrum of this system at hand, we analyze the thermodynamic quantities within the canonical and micro-canonical ensembles of an ideal gas made up of N indistinguishable particles at the Planck scale. The results show a complete consistency between both statistical descriptions. Furthermore, a comparison with the results obtained in the context of minimal length scenarios and black hole theories indicates that the maximal length in this theory induces logarithmic corrections of deformed parameters which are consequences of a strong quantum gravitational effect.
Protective PEEP and Lung Capacity May Be Determined by a Rapid PEEP-step Procedure
Authors: Grivans Christina , Stenqvist Ola 
Published: May 2021

Abstract
Background: A protective ventilation strategy should be based on assessment of lung mechanics and transpulmonary pressure, as this is the pressure that directly “hits” the lung. Esophageal pressure has been used for this purpose but has not gained widespread clinical acceptance. Instead, respiratory system mechanics and airway driving pressure have been used as surrogate measures. We have shown that the lung P/V curve coincides with the line connecting the end-expiratory airway P/V points of a PEEP trial. Consequently, transpulmonary pressure increases as much as PEEP is increased. If the change in end-expiratory lung volume (ΔEELV) is determined, lung compliance (CL) can be determined as ΔEELV/ΔPEEP and ΔPTP as tidal volume times ΔPEEP/ΔEELV. Methods: In ten patients with acute respiratory failure, ΔEELV was measured during each 4 cmH2O PEEP-step from 0 to 16 cmH2O and CL for each PEEP interval calculated as ΔEELV/ΔPEEP giving a lung P/V curve for the whole PEEP trial. Results: Lung P/V curves showed a marked individual variation with an overall lung compliance of 43–143 ml/cmH2O (total inspiratory volume divided by end-inspiratory transpulmonary plateau pressure at PEEP 16 cmH2O). The two patients with lowest lung compliance were non-responders to PEEP with decreasing lung compliance at high PEEP levels, indicating over-distension. Patients with higher lung compliance had a positive response to PEEP with successively higher lung compliance when increasing PEEP. A two-step PEEP procedure starting from a clinical PEEP level of 8 cmH2O gave almost identical lung P/V curves as the four PEEP-step procedure. The ratio of airway driving pressure (ΔPAW) to transpulmonary driving pressure (ΔPTP/ΔPAW) varied between patients and changed with PEEP, reducing the value of ΔPAW as surrogate for ΔPTP in individual patients. Conclusion: Separation of lung and chest wall mechanics can be achieved without esophageal pressure measurements if ΔEELV is determined when PEEP is changed . Only a two-step PEEP procedure is required for obtaining a lung P/V curve from baseline clinical PEEP to end-inspiration at the highest PEEP level, which can be used to determine the PEEP level where transpulmonary driving pressure is lowest and possibly least injurious for any given tidal volume.Trial registration: ClinicalTrials.gov, NCT04484727. Registered 24 July 2020 – Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04484727?term=Lindgren%2C+Sophie&cntry=SE&draw=2&rank=1
Surface Chemistry Studies of Emission and Thermal Behaviour of Developed Composites for Building Ceiling Materials
Authors: DIRISU JOSEPH OSEKHOGHENE , Oyedepo Sunday , Fayomi Ojo , Salawu Enesi , Oyekunle John , Asere Abraham , Efemwenkiekie Kelvin 
Published: May 2021

Abstract
The emission of harmful elements from burning building ceiling materials and their attendant health effects on inhabitants within the vicinity of the emitted harmful elements is increasingly becoming a source of concern globally. Hence, the need to develop eco-friendly flame-retardant composite materials suitable for house ceiling purposes to forestall unwanted toxic emissions. This work identified the chemical structure of developed composite products and their emission performance during combustion. X-ray Diffraction (XRD) analysis was used for phase quantification and E550 combustion gas analyzer for emission characterization of the developed composites. Thermolyne 950oC oven was employed for the combustion analysis of the prepared composite at 500oC. Quasi negligible SO2 level and CO2 exist; however, A4, 0.3Aldr0.23Cmt0.3Si0.05G0.12CS recorded maximum CO level, an indication of toxic affluence. The low mass losses of all of the composite materials, especially for A2, 0.6Aldr0.34Cmt0.05G0.01OBSretard significantly due to its activities by the retardant constituent. The flame retardant nature of all produced composite was evidenced in their elemental composition, as there was an absence of flammable element and presence of stable insulating compound providing retardance to flame occurrences. These suppressions in the flame inclination of the reinforced materials were noticed within the boundaries of the ceiling crystals from the structural examination. The intermetallic phase from the diffraction intensities showed the presence of a significant second bond interstitial solid-phase across the matrix, especially for 0.6Aldr0.34Cmt0.05G0.01OBS ceiling material.
Divergent Metastatic Patterns Between Esophageal Squamous-cell Carcinoma and Esophageal Adenocarcinoma: a Propensity-matched Analysis
Authors: Liu Ganwei , Yang Feng , Wang Shaodong , Li Jianfeng , Zhou Zuli 
Published: May 2021

Abstract
Background: To explore the different metastatic patterns between esophageal squamous-cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC).Methods: For this propensity-matched analysis, we used data from the latest iteration of the Surveillance, Epidemiology, and End Results (SEER) database and included patients diagnosed with esophageal cancer from 2010 to 2017. Results: A total of 20,189 patients were identified, including 6,610 ESCC and 13,579 EAC. After propensity score matching, 4597 pairs were selected. Compared with ESCC, EAC had a higher rate of liver metastasis (P < 0.001) and brain metastasis (P < 0.001), and a lower rate of lung metastasis (P < 0.001), with no signiﬁcant diﬀerence in bone metastasis (P = 0.255). The liver preferentially co-metastasized with lung in both cohorts. Brain metastasis was commonly observed in combination with other organ metastases in EAC. Conclusions: There are major differences in metastatic patterns between ESCC and EAC. The patterns identified may reflect the underlying biology of metastatic esophageal cancer and have potential to influence future monitoring strategies depending on clinical settings.
Decreased Sperm Motility is Associated with Increased Seminal Plasma IGF-I, IGF-II, IGFBP-2 and PSA Levels in Male Infertility
Authors: Fu Li , Yuen Kevin , Tint Aye Nyein , Hoffman Andrew R. , Bongso Ariff T. , Lee Kok Onn 
Published: May 2021

Abstract
PurposePrevious studies have suggested the involvement of serum IGFs and IGFBPs in the regulation of the female reproductive system. Little is known of these peptides in the seminal plasma (SP) of men and their potential effects on fertility. We assessed SP levels of these peptides in infertile men with low sperm motility (asthenozoospermic; AZ) and low sperm counts (oligozoospermic; OZ), its effects on in vivo sperm motility, and whether aging affects these peptides.MethodsTwenty eight infertile men (AZ; n = 18 and OZ; n = 10) and 20 fertile normozoospermic (NZ) men were studied. Seminal plasma IGF-I, IGF-II, IGFBP-2, IGFBP-3 and PSA levels were measured, and spermatozoa mRNA transcript patterns were examined.ResultsAsthenozoospermic men had higher SP IGF-I, IGF-II, IGFBP-2 and PSA levels than NZ and OZ men (all P < 0.05), whereas SP IGFBP-3 levels were no different between the three groups. Sperm count positively correlated with SP IGF-I, IGF-II and IGFBP-2; sperm motility negatively correlated with SP IGF-II and IGFBP-2; and age correlated positively with SP IGF-II (all P < 0.04). The expression of IGF-I and IGF-II mRNA and mRNA receptors was detectable, but no variations in transcript levels were noted. ConclusionDecreased sperm motility, but not sperm count, in infertile AZ men is associated with increased SP IGF-I, IGF-II, IGFBP-2 and PSA levels. Changes in SP IGFs and their interactions with IGFBPs and IGF receptors, and PSA levels suggest a role of these SP peptides in modulating sperm motility and possibly prostate disease development in aging men.