bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenobarbitone Induced Toxic Epidermal Necrosis in a Young Patient - A Rare Clinical Presentation: A Case Report and Brief Review of the Literatures
Authors: Ayele Biniyam A. , Ali Kemal , Mulatu Eliyas 
Published: April 2021

Abstract
Background: Toxic epidermal necrolysis (TEN)/ Stevens-Johnson syndrome (SJS) is the spectrum of severe, acute, mucocutaneous, Ig E mediated hypersensitivity reaction; universally related to different drugs. Phenobarbitone is known to cause hypersensitivity reactions with benign pattern; ranging from a mild to moderate rashes but not life-threatening reactions such as TEN/SJS. Little is known about TEN in asthmatic patient. To the best of our knowledge, this is the first case of Phenobarbitone-induced TEN in a young asthmatic patient from the sub Saharan African. Case report: We report a 14-year-old right handed asthmatic male patient who presented with extensive blister skin eruptions involving the whole body including mouth ear canal later followed by skin exfoliation associated with low grade fever, sore throat, and dysphagia. The hypersensitivity skin reaction developed two weeks after initiation of Phenobarbitone of 100mg twice daily for a new onset generalized tonic clonic seizure. The exfoliation also involved oral and Conjunctival mucosa; with estimated 65% body surface area involvement; hence the diagnosis of Toxic epidermal necrosis was made. The Laboratory investigations were relevant for mild leucocytosis, prolonged prothrombin time, and reduced albumin. Phenobarbitone was discontinued and replaced with clonazepam; and the patient was managed with fluids replacement, IV antibiotics, twice daily wound care, analgesics, and naso gastric tube feeding. On subsequent days in intensive care unit (ICU), the patients’ clinical condition started improving; the skin lesion also started to heal and exfoliate in most of the affected skin surface areas, and the patient was discharges improved after ten days of ICU care.Conclusion: In summary, the present case describes, a 14-years-old young child with history of allergy in a form of asthma and new onset seizure disorder; and developed toxic epidermal necrosis following exposure to Phenobarbitone. This case also highlighted the benign prognosis observed in paediatrics population with TEN.
Testing Hypotheses About Glacial Dynamics Using a Statistical Model of Paleo-Climate
Authors: Kaufmann Robert , Pretis Felix 
Published: April 2021

Abstract
We test hypotheses about glacial dynamics by evaluating the ability of a linear statistical model to simulate climate during the previous ~800,000 years. During this period, the linear model simulates the timing and magnitude of glacial cycles, including the saw-tooth pattern in which ice accumulates gradually and ablates rapidly, without falsely simulating an interglacial after each peak in obliquity. Conversely, the linear model fails to simulate experimental observations that are created by a nonlinear data generating process. Together, these (in)abilities suggest that nonlinearities, threshold effects, bifurcations, and/or phase-specific governing equations do not play a critical role in glacial cycles during the late Pleistocene. Furthermore, the model’s accuracy throughout the sample period suggests that changes in orbital geometry create the Mid-Brunhes event.
Performance evaluation and analysis of four waves mixing in DWDM optical communications
Authors: Elsayed Ebrahim E. 
Published: April 2021

Abstract
Optical nonlinearities give rise to many ubiquitous effects in optical fibres. These effects are interesting in them and can be detrimental in optical communication. In the Dense Wave length division multiplexing system (DWDM) the nonlinear effects plays important role .DWDM system offers component reliability, system availability and system margin. DWDM system carries different channels. Hence power level carried by fiber increases which generates nonlinear effect such as SPM ,XPM, SRS, SBS and FWM. Four waves mixing (FWM) is one of the most troubling issues. The FWM gives crosstalk in DWDM system whose channel spacing is narrow. Wavelength exchanging enables data swapping between two different wavelengths simultaneously. These phenomena have been used in many applications in Wavelength Division Multiplexing (WDM) optical networks such as, wavelength conversion, wavelength sampling, optical 3R, optical interconnects and optical add-drop multiplexing.
Short Version of the Inventory of Parental Representations for Attachment Assessment Among Adolescents
Authors: Lamourette Marilou , Ligier Fabienne , Guillemin Francis , Epstein Jonathan 
Published: April 2021

Abstract
Background: The Inventory of Parental Representations (IPR), a self-administered questionnaire, was developed primarily to identify styles of attachment in adolescence. However, it did not present stable psychometric properties in the various American studies carried out. The aim of this study was to adapt the IPR in French and to provide a shorter version with improved psychometric properties and a sound content.Methods: The content validity was carried out by an expert committee and 10 adolescents. The study of the metric properties of the French version of the IPR was realized in a sample of 275 responses. In case of mediocre results in the CFA of the existing structures, the development of a new IPR structure was planned (Classical Test Theory and Rasch Modelling).Results: Out of 62 items translated, 13 needed adaptation. The analysis of its metric properties produced mediocre results. In a group of 275 adolescent’s responses, a step-by-step process was implemented. Content and psychometric property analyses generated a paternal Short-IPRF (15 items) and a maternal Short-IPRM (16 items) scale with sound content and good psychometric properties confirmed in an independent sample of 795 responses (Short-IPRF: Comparative Fit Index (CFI)=0.987, Tucker-Lewis Index (TLI)=0.982, Root Mean Square Error of Approximation (RMSEA)=0.027; Short-IPRM: CFI=0.953, TLI=0.927, RMSEA=0.068). Using Rasch modelling, the attachment was correctly measured overall especially for insecure attachment. Conclusions: A step-by-step process involving both content analysis and psychometric property analysis led to the generation of two questionnaires, a paternal scale, the Short-IPRF, and a maternal scale, the Short-IPRM.
Medical Students’ Readiness for Virtual Clerkships During the COVID-19 Pandemic.
Authors: Al-Moslih Ayad , Shami Rula , Al-Jayyousi Ghadir Fakhri , Du Xiangyun , Al-Awaisi Alla , Rahim Hanan Abdul , Diab Mohammad , Bawadi Hiba 
Published: April 2021

Abstract
BackgroundThis study aims to qualitatively examine the readiness of medical students to change to virtual clerkship during the pandemic, from both the faculty preceptors and students’ perspectives’. MethodsA qualitative study was conducted based on the framework of readiness to change. Focus group discussions with students, and semi-structured interviews with clinical faculty members were done using appropriate online platforms. Transcripts were then analyzed using a qualitative phenomenological approach.Results Twelve themes emerged which are 1) Perceptions about the university decision and its communication to students, 2) A Perceived Lack of clinical experience, 3) Student safety , 4) Students’ role as members of the medical team facing the pandemic, 5) Quality and design of VI and the skills it offered, 6) Belief in own ability to succeed in the VC, 7) Confidence that VC would reach its goals, 8) New enhanced learning approaches, 9) Acquired skills, 10) Preparing students for new types of practice in the future, 11) Academic support and communication with faculty and college, 12) Psychological support. Medical students showed limited readiness to undertake a virtual clerkship and not play their role as healthcare professionals during the pandemic. They perceived a huge gap in gaining clinical skills virtually and asked for quick return to training sites.ConclusionsMedical students were not ready for virtual clerkships. There will be a need to integrate novel learning modalities such as patient simulations and case-based learning in order to meet future demands of the medical profession and enhance the efficiency of virtual clerkships.
Effect of acupuncture for diminished ovarian reserve: study protocol for a randomized controlled trial
Authors: Xu Huanfang , Hao Mingzhao , Zheng Chensi , Yang Huisheng , Yin Yaqian , Yang Li , Fang Yigong 
Published: April 2021

Abstract
Background: Diminished ovarian reserve (DOR) is described as reduced fecundity. A satisfactory treatment is lacking despite the upward trend of the prevalence. Acupuncture has been reported as an alternative therapy for female infertility. The purpose of this study is to investigate the effect of acupuncture for women with DOR.Methods/Design: In this randomized controlled trial, a total of 120 women with DOR will be randomized to receive either acupuncture or sham acupuncture for 12 weeks. The primary outcome is the antral follicle counting (AFC).Discussion:This study is expect to investigate the effect of acupuncture versus superficial needling in improving ovarian reserve for women with DOR.Trial registration:Acupuncture-Moxibustion Clinical Trial Registry (ChiCTR1800014988).
Properties of the Transfers from LEO to the Retrograde-GEO using Lunar Swing-by in a Three-Body Model
Authors: He Boyong , Ma Pengbin , Li Hengnian 
Published: April 2021

Abstract
A monitor-satellite on a retrograde geostationary earth orbit (retro-GEO) gives the GEO-assets debris-warnings per 12 hour. The properties of the transfers from a low earth orbit to the retro-GEO using lunar swing-by without middle-way maneuver are exhibited in a three-body model. Based on the Poincaré-section methodology, the proof of the existence of this transfer is proven in the planar circular restricted three-body problem (CR3BP) model. Then, the maximum altitude of the perilune of this transfer is solved using the sequence quadratic programming optimization algorithm. Besides, the orbital inclination changeable capacity of this transfer is calculated in the spatial CR3BP model by the continuation of the orbital design values in the planar CR3BP model. The numerical results show that the maximum altitude of the perilune is 892 km and the maximum orbital inclination changeable capacity is 138 degree relative to the plane of the Moon’s path. Further analysis show that the minimum sum of the two-impulse velocity increments (i.e., departure from LEO and insert into the retro-GEO) is 4.224 km/s, the change of the orbital inclination is 107 degree relative to the plane of the Moon’s path in this case. Due to the maximum angle of the plane of the Moon’s path on the equator is 28.6 degree per Metonic cycle (i.e., 18.6 years), everyday has a month window to match the longitude of the launch-site for trans-lunar injection.
A case study of the application of WEKA software to solve the problem of liver inflamation
Authors: Vujović Željko 
Published: April 2021

Abstract
The aim of this paper was to consider the reliability of the basic metrics of evaluation of classification models: accuracy, sensitivity, specificity and precision. The WEKA software tool was applied to the "Hepatitis C virus (HCV) for Egyptian patients dataset". The algorithms Bayesnet, Naivebayesh, Multilayer Perceptron, J48 and 10-fold cross validation were used in the study. The main results obtained are that, with all four algorithms in question, they achieved approximately the same accuracy of correctly classified specimens. BaiesNet - 22.96%, NaiveBaies - 26.14%, MultilaierPerceptron - 26.57% and J48 - 25.27%. Binary classification metrics - sensitivity, specificity and precision show very different values, depending on the intended class. Metric specificity, for all four algorithms, shows that a value that is in most of the range of possible values ​​[0,1]. Metric sensitivity and precision, for all four algorithms, showed values ​​that are in the lower part of the range of possible values ​​[0,1]. The results of this study showed that WEKA software could not yet be considered as a relevant tool for the diagnosis of Hepatitis C Virus, on whose data set it was applied.
Neuromorphic processing at Tera-OP/s speeds with soliton crystal microcombs
Authors: Tan Mengxi , Xu Xingyuan , Moss David 
Published: April 2021

Abstract
Convolutional neural networks (CNNs), inspired by biological visual cortex systems, are a powerful category of artificial neural networks that can extract the hierarchical features of raw data to greatly reduce the network parametric complexity and enhance the predicting accuracy. They are of significant interest for machine learning tasks such as computer vision, speech recognition, playing board games and medical diagnosis [1-7]. Optical neural networks offer the promise of dramatically accelerating computing speed to overcome the inherent bandwidth bottleneck of electronics. Here, we demonstrate a universal optical vector convolutional accelerator operating beyond 10 Tera-OPS (TOPS - operations per second), generating convolutions of images of 250,000 pixels with 8-bit resolution for 10 kernels simultaneously — enough for facial image recognition. We then use the same hardware to sequentially form a deep optical CNN with ten output neurons, achieving successful recognition of full 10 digits with 900 pixel handwritten digit images with 88% accuracy. Our results are based on simultaneously interleaving temporal, wavelength and spatial dimensions enabled by an integrated microcomb source. This approach is scalable and trainable to much more complex networks for demanding applications such as unmanned vehicle and real-time video recognition.
Polyphosphate (PolyP) for alveolar cleft repair, study protocol for a pilot randomized controlled trial.
Authors: Alkaabi Salem , Kalla Diandra S Natsir , Fauzi Abul , Tajrin Andi , Müller WEG , Schröder HC , Wang XH , Forouzanfar Tim , Helder MN , Ruslin M , Alsabri Ghamdan 
Published: April 2021

Abstract
Objective: Bone grafting is an important surgical procedure to restore missing bone in patients with alveolar cleft lip/palate, aiming to stabilize either sides of maxillary segments by inducing new bone formation, and in bilateral cleft cases also to stabilize the pre- maxilla. Polyphosphate (PolyP), a physiological polymer composed of orthophosphate units linked together with high-energy phosphate bonds, is a naturally existing compound in platelets which, when complexed with calcium as Ca-polyP microparticles (Ca-polyP MPs), was proven to have osteoinductive properties in preclinical studies. Aim: To evaluate the feasibility, safety and osteoinductivity of Ca-polyP MPs as a bone-inducing graft material in humans. Methods: This prospective non-blinded first-in-man clinical pilot study shall consist of 8 alveolar cleft patients of 13 years or older to evaluate the feasibility and safety of Ca-PolyP MPs as a bone-inducing graft material. Patients will receive Ca-polyP graft material only, or Ca-polyP in combination with biphasic calcium phosphate (BCP) as a bone substitute carrier. During the trial, the participants will be investigated closely for safety parameters using radiographic imaging, regular blood tests, and physical examinations. After 6 months, a hollow drill will be used to prepare the implantation site to obtain a biopsy. The radiographic imaging will be used for clinical evaluation; the biopsy will be processed for histological/histomorphometric evaluation of bone formation. Discussion: This is the first-in-man study evaluating the safety and feasibilty of the polyP as well as the potential regenerative capacity of polyP using an alveolar cleft model.Trial registration {31a} The clinical trial protocol received a written approval by the ethical committee of Faculty of Medicine, Hasanuddin University, Makassar, Indonesia with code number 1063/UN4.6.4.5.31/PP36/2019. On completion of the trial, the results on safety, feasibility and bone formation with polyP as graft material will published.
Psychometric properties of the Inventory of Interpersonal Problems (IIP-C) used with a clinical sample of adolescents: a preliminary study
Authors: Israel Pravin , Langeveld Johannes Hendrik 
Published: April 2021

Abstract

Background:
Interpersonal problems are consistently identified with psychopathology that often has its onset in adolescence. Most of the commonly used instruments in child and adolescent psychiatry target non-interpersonal problems. The Inventory of Interpersonal Problems (IIP) is a widely studied and utilized instrument in the adult mental health field.

Aims:
This study aimed to examine the psychometric properties of the IIP (circumplex version) used with a clinical adolescent population. Method: Sixty-two adolescents (13-17 years) who received treatment in a child and adolescent mental health clinic (CAMHS) were included in the study. To establish reliability and validity, we conducted confirmatory factor analyses, internal consistency, and validity analyses.

Results:
Confirmatory analyses did not show optimal model fit. However, other indices like CFI and TLI were promising. The reliability of the eight scales was in the same range as previous studies and acceptable. There were expected significant correlations between IIP-C scales and the broadband scales of Youth Self-report (YSR).

Conclusion:
The pioneer nature and its clinical focus are strengths however, there is a need for more research. The promising results are encouraging, and future research could also explore how best to bring the instrument into the digital age.
Augmented HLL Riemann solver including slope source term for 1D mixed pipe flows
Authors: Chen Shangzhi , Zheng Feifei , Liu Xin 
Published: April 2021

Abstract
In this paper, the augmented version of finite volume Harten–Lax–van Leer (HLL) solver, including source terms, is extended to free-surface and pressurized mixed pipe flows over complex and frictional topography. This augmented HLL Riemann solver is employed for the flux approximation at the cell interface, where source terms are split into two parts based on the wave propagation speed. The friction term is treated using a splitting implicit method to maintain stability over dry beds. The Preissmann slot method is adopted to reproduce pressurized flow in the conduit. The performances of the numerical model are investigated by several numerical tests and compared with existing methods showing clear improvements.
Citizen deliberation in the context of Uruguay's first National Water Plan
Authors: Lázaro Marila , Bortagaray Isabel , Trimble Micaela , Zurbriggen Cristina 
Published: April 2021

Abstract
As part of the formulation of the first National Water Plan (NWP) in Uruguay, a mini-public process called ‘Citizen Deliberation on Water (Deci Agua)’ was developed in 2016. While the draft of the plan was being discussed in the formal arenas of water governance (Basin Commissions and Regional Water Resources Councils), a University research team (led by the authors), in coordination with the national water authority, adapted the mechanism of consensus conferences in order to incorporate the citizens’ visions and to contribute to public understanding of the NWP challenges. This article analyses the main aspects of the developed participation strategy and discusses them regarding a set of quality criteria used to evaluate deliberative processes. Although the final version of the NWP (passed by decree in 2017) incorporated some of the contributions of the Citizen Panel, an in-depth analysis of the scope of the deliberative process of Deci Agua allows us to delve into some key aspects related to the quality of participation processes and the challenges. A mixed approach that combines stakeholder participation and lay citizens is novel and desirable in water governance since it increases the scope of participation, deepens the legitimacy of decision-making and improves the public debate.
Medication Without Harm: Developing Optimal Medication Error Reporting
Systems
Authors: Shiima Yuko , Malik Muzaffar , Okorie Michael 
Published: April 2021

:
Medication errors are amongst the most frequently occurring healthcare-related incidents
and have the potential to lead to life-threatening harm to patients. An incident reporting system
is a traditional approach to the improvement of patient safety and entails the retrieval of information
from incident reports. This not only provides a better understanding of causes and contributing
factors but also enables the collection of data on the severity of incidents, system deficiencies
and the role of human factors in safety incidents. Medication error reporting systems are often developed
as a part of larger incident reporting systems that deal with other types of incidents. Although
a rise in the prevalence of medication errors has led to an increased demand for medication
error reporting, little is known about the characteristics and limitations of medication error reporting
systems. The authors broach the subject of medication error reporting systems and propose a
more robust and standardized approach.
Advances in Carbidic Austempered Ductile Iron (CADI) - A Wearresistant Material
Authors: Maddi Lakshmiprasad , Likhite Ajay 
Published: April 2021

Background:
Ductile irons provide a more viable alternative for malleable cast iron in
areas that do not demand extreme wear resistance. Austempering of ductile irons was a well researched
area in the last two decades. Attempts to further improve the wear resistance led to the
development of Carbidic austempered ductile iron (CADI), wherein the carbides contribute to wear
resistance. Combination of ausferritic matrix, graphite nodules, and carbides (eutectic and alloy)
symbolizes the microstructure of CADI.

Methods:
Two principal approaches adopted by the researchers to change the microstructure are (i)
addition of carbide forming elements (ii) heat treatment (s).

Results:
Both the above methods result in the refinement of graphite nodules, carbide precipitations,
along fine ausferrite.

Conclusion:
Improvement in hardness, toughness and wear resistance was observed largely as a
consequence of fine carbide precipitations and formation of martensite.