bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraocular Schwannoma: Case Series of 28 Patients and Literature Review
Authors: Liu Yue-Ming , Dong Li , Xu Xiao-Lin , Li He-Yan , Yang Qiong , Zhang Rui-Heng , Wei Wen-Bin 
Published: September 2021

Abstract
Background: Intraocular schwannoma is a rare intraocular tumor, which is often misdiagnosed. We aimed to analyze the demographics and clinical characteristics of patients with intraocular schwannoma.Methods: Retrospective case series were collected from May 2005 to July 2021 in Beijing Tongren Hospital. Then a literature review was also performed.Results: A total of 28 patients were diagnosed with intraocular schwannoma histopathologically. The median age (range) of the included patients was 39 (12-64) years old, among whom half subjects were female. The most common symptom was visual loss (75.0%), followed by visual field loss (10.7%). Intraocular schwannoma presented as nonpigmented mass, which occurred mainly in ciliary body (42.9%), followed by choroid (32.1%) and ciliochoroid (25.0%).16 patients (57.1%) were clinically misdiagnosed as uveal melanoma. Tumor excision was performed for all patients and increased light transmission was detected in half cases. In the consecutive follow-up (median: 6.0 years, range: 0.5-16.0 years), no recurrence or metastasis case was detected.Conclusions: Intraocular schwannoma is a rare benign intraocular tumor. It usually presents as nonpigmented mass, which is easily misdiagnosed as nonpigmented uveal melanoma.
Notch1 Signaling Modulates Hypoxia-induced Multidrug Resistance of Human Laryngeal Cancer Cells
Authors: Li Dawei , Xu Dan , Chen Penghui , Xie Jin 
Published: September 2021

Abstract
Background: Laryngeal carcinoma is one of the common malignant tumors of the head and neck. Multidrug resistance (MDR) remains a critical problem in the chemotherapy for patients with laryngeal cancer. This study aims to clarify the role and mechanisms of Notch1 signaling on MDR induced by hypoxia in laryngeal cancer cells.Methods and Results: Laryngeal carcinoma cells were cultured under normoxia or hypoxia. Notch1 expression was inhibited by small interfering RNA (siRNA). The expression of Notch1, Hes1, Hey1, MDR1 and survivin mRNA was determined by Real-time PCR. The expression of Notch1, Notch1 intracellular domain (N1ICD), MDR1/P-gp and survivin protein was detected by Western blot. Current research showed that hypoxia could upregulate Notch1 expression and the activity of Notch1 signaling. Furthermore, suppression of Notch1 expression could effectively down-regulate the activity of Notch1 signaling and the expression of MDR and survivin genes in laryngeal cancer cells under hypoxia (P<0.05). Cell Counting Kit-8 (CCK-8) assay confirmed that the sensitivity of hypoxic laryngeal cancer cells to a variety of drugs could be up-regulated by suppressing Notch1 expression (P<0.05). Additionally, flow cytometry (FCM) showed that suppression of Notch1 expression significantly increased cisplatin-induced apoptosis and intracellular Rh123 (Rh123) accumulation in hypoxic laryngeal carcinoma cells (P<0.05). Conclusions: Notch1 signalling could be regarded as a pivotal regulator for mediating hypoxia-induced MDR in laryngeal cancer cells by regulating survivin-mediated apoptosis resistance and MDR1/P-gp-mediated drug transport.
Coupling photocatalytic water oxidation with organic reduction: strategy for using water to reduce organic molecules
Authors: Tian Xinzhe , Guo Yinggang , Liu Wenbo , Zheng Yi , Ren Yun-Lai , An Wankai , Niu Caoyuan , Wang Jianji 
Published: September 2021

Abstract
The utilization of readily available and non-toxic water by photocatalytic water splitting is highly attractive in green chemistry. Herein we report that light-induced oxidative half-reaction of water splitting is effectively coupled with reduction of organic compounds, which opens up, for the first time, an avenue to use water as an electron donor to enable reductive transformations of organic substances. The used photocatalyst (Pd/g-C3N4*) was synthetized by a novel method where Pd/g-C3N4 was irradiated by light in the presence of Na2CO3 and H2O. The present strategy allowed a series of aryl bromides to undergo the reductive coupling to provide biaryl products in low to high yields. Preliminary mechanistic investigation suggests that the reaction proceeds through the single electron transfer from Pd to aryl bromides. This work will guide chemists to use water as a reducing agent to develop green procedures for various organic reactions.
The Influence of Compost Amendments on Bioaccumulation of Potentially Toxic Elements by Pea Plant Cultivated in Mine Degraded Soils
Authors: Irfan Muhammad , Shah Muhammad Azhar , Alam Mehboob , Khan Anwarzeb , Khan Muhammad Amjad , Rahman Saifur , Alsaiari Mabkhoot A , Jalalah Mohammed Saeed , Khan Mohammad Kamal Asif , Ghanim Abdulnour Ali Jazem 
Published: September 2021

Abstract
Potential toxic metals (PTEs) accumulation in soil and water is one of the major sources of food crop contamination. PTEs remediation from soil can be enhanced by addition of organic matter to the growing media. An experiment was carried out to investigate the effect of different organic amendments on the accumulation of PTEs in pea plant grown on mine degraded soils. Mining soils from chromite mine (CM), soap stone mine (SSM), manganese mine (MM) and quartz mine (QM) were mixed with vermicompost (VC), leaf mould (LC) and spent mushroom compost (SMC) along with garden soil at 1:1:1 ratio. Various growth and yield related attributes of pea plant as well as PTEs concentrations in soil and plants were studied. The highest Cd (2.62 mg kg−1) and Cr (13.6 mg kg−1) concentration was reported in CM soil, while Pb (23.3 mg kg−1) and Mn (59.2 mg kg−1) concentration in SSM and MM soil, respectively. Mining soils significantly reduced the plant growth and yield, while organic amendments reduced the PTEs availability and increased pea plant growth. Comparing the various organic fertilizers used, it was observed that VC efficiently reduced Cd, Cr, Pb and Mn uptake by pea plant, subsequently, improved pea plant growth. In order to assess the effects of various amendments on PTEs health risk reduction various risk indices including, plant trafser factor, average daily intake, health risk, target hazard quotient and target cancer risk were also calculated and the results revealed that application of compost particularly VC significantly reduced the dietary intake and health risks of PTEs.
Lymph-Node-Sampler-Based Nucleic Acid Detection Helps to Diagnose and Control African Swine Fever in Pig Production
Authors: Li Xiaowen , Li Yang , Fan Mingyu , Fan Shiran , Gao Wenchao , Yuan Peng , Ren Jing , Li Jingtao , Yu Jincheng , Wu Weisheng , Li Junxian , Yu Qiannan , Shao Zhenwen , Yan Zhichun 
Published: September 2021

Abstract
Background: African swine fever (ASF) is a highly contagious hemorrhagic and transboundary animal disease. It has rapidly spread to many regions of the world and is responsible for serious production and economic losses. However, clinical diagnosis is impractical for the similar classic symptoms of ASF and several other normal diseases. How to make a definite diagnosis is a top priority. Results: In the present study, lymph node samples were collected by the patented “lymph node sampler”, which makes the sampling safer, more efficient and minimally invasive. The ASF virus (ASFV) contents of lymph node sample as well as serum, oral fluid, nasal and rectal swab samples from pig production line were detected by real-time PCR. The big data results demonstrated that the lymph node samples contained more stable and strongly positive ASFV nucleic acid than the porcine exudate and serum samples. Taking the lymph node sample is one of the assistant ways in diagnosing pigs suspected of having ASF. We supervised twenty farms that realized the accurate diagnosis and eliminating of the risk in the shortest time period by using lymph node sampler. Conclusions: Our findings suggest that the lymph node sample is an ideal tissue for diagnosing ASFV infection. The lymph node sampler is a convenient tool for lymph node sampling for practitioners.
BRAF p.V600E Mutation as Acquired Resistance Mechanism of Lorlatinib in a ROS1 Rearrangement Lung Adenocarcinoma Patient with Primary Ceritinib Resistance
Authors: Liu Zhulin , Han Zhaojie , Nie Naifu , Feng Mingxia , Li Li , He Yong 
Published: September 2021

Abstract
Both crizotinib and ceritinib are recommended as first-line theray for NSCLC with ROS1 rearrangements, with the latter having stronger infiltration ability across blood-brain barrier. Here we report for the first time that a brain metastatic adenocarcinoma patient with CD74-ROS1 rearrangement was sensitive to crizotinib but resistant to ceritinib. Intracranial progression happened after 7 months of crizotinib, and sencond-line lorlatinib resulted in partial response and a PFS of 8 months. Upon lorlatinib resistance, repeated NGS detection of ctDNA from peripheral blood showed BRAF p.V600E, CD74-ROS1 and ROS1 pG2032R. Then, Trametinib, dabrafenib, and cabozantinib was administered to the patient. However, disease progressed very quickly and the patient passed away only one month later, with a overall survival of months. The last ctDNA test, one week before death of the patient, found that BRAF p.V600E disappeared, leaving only CD74-ROS1and ROS1 pG2032R,with a very high frequency. To our knowledge, this is the first case report of a ROS-1 rearrangement lung cancer patient that is sensitive to crizotinib but resistant to ceritinib, and BRAF p.V600E as resistant mechanism for lorlatinib.
Evaluation of the Dynamic Behavior, Elastic Properties, and in Vitro Bioactivity of Some Borophosphosilicate Glasses for Orthopedic Applications
Authors: Abushanab Waheed S. , Moustafa Essam B. , Youness Rasha 
Published: September 2021

Abstract
The present work employed the finite element model (FEM) to predict the influence of successive increases in borate (B2O3) contents, from 0 to 25 mol%, on both the mechanical properties and dynamic behavior. By feeding the isotropic elasticity characteristics of the phosphosilicate glass to the model, such as Young's modulus, density, and maximum compressive stress of the produced glass samples to fit the aim of their clinical use. The effect of successive addition of B2O3 on the in vitro bioactivity of the examined glasses in addition to examined after being dipped in simulated body fluid (SBF) at different times. Moreover, tracking the formation of hydroxyapatite (HA)-like layers on their surfaces using X-ray diffraction technique (XRD) technique and scanning electron microscopy (SEM). The results obtained indicated that increasing B2O3 content to 25% was responsible for improving the deflect resistance by 39%. On the other hand, neither shear stress nor principles stress was affected by this increase in B2O3 content. Moreover, the gradual increases in B2O3 contents were very helpful in improving the bioactivity of the samples. From these promising results, the prepared glasses can be successfully used in bone replacement applications.
Safety and Feasibility of Intravascular Ultrasound-Guided Robotic
Authors: Kimura Takumi , Koeda Yorihiko , Ishida Masaru , Yamaya Shohei , Kikuchi Sayaka , Tsuji Keiko , Ishisone Takenori , Goto Iwao , Itoh Tomonori , Morino Yoshihiro 
Published: September 2021

Abstract
PurposePrevious studies have demonstrated the benefit of intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) for preventing longitudinal geographic miss (LGM). However, it is yet unclear whether IVUS guidance is useful for robotic PCI (R-PCI). This retrospective observational study sought to compare expected stent landing positions between IVUS and angiography.MethodsA total of 58 consecutive patients with stable angina who underwent IVUS-guided R-PCI was enrolled. The stent landing position was angiographically marked using a balloon marker before stenting followed by measurements of the expected stent length using balloon pullback. Subsequently, pre-stenting IVUS was performed to determine stent landing. All pre-PCI IVUS images were assessed for lesion length and percent plaque volume (%PV) using both IVUS and angiographic marking. LGM was defined as a residual %PV > 50% at either the distal or proximal stent edge, any stent edge dissection, and/or additional stent deployment immediately after stenting. Major adverse cardiac events were assessed at the 6-month follow-up.ResultsThe included patients, 41 of whom were male, had an average age of 67.1 ± 10.1 years. IVUS guidance had significantly longer lesion lengths compared to angiographic marking. Based on IVUS-guided stent deployment, 9 cases exhibited LGM immediately after stenting. IVUS-marked landing points had a significantly smaller %PV and significantly larger LA compared to those for angiography. No adverse cardiac events were noted during the 6-month follow-up.ConclusionIVUS-guided R-PCI was safe and may be better at preventing LGM compared to angiography-guided R-PCI.
Exploring Efficiency of Biochar in Enhancing Water Retention in Soils with Varying Grain Size Distributions using ANN Technique
Authors: Garg Ankit , Wani Insha , Zhu Honghu , Kushvaha Vinod 
Published: September 2021

Abstract
Recently, incentives have been provided in many countries, including Canada and Denmark, to produce biochar for construction usage. This is done because biochar is carbon negative and can help achieve the emission reduction goal of 2030. This technical note aims to analyze the efficiency of biochar in soils with varying grain size distribution for enhancing water retention capacity (WRC). The combinations of biochar content and grain size distributions corresponding to the maximum and minimum efficiency were explored. Artificial Neural Network (ANN) based model for predicting Soil Water Characteristic Curve (SWCC) as a function of soil suction and grain size distribution was developed. A new factor (the ratio of fine (silt + clay) and coarse (sand) content) was proposed for the interpretation of the efficiency of biochar in soils. The newly developed model is able to predict SWCC reasonably well. Biochar amendment is found to influence both dry and wet sides of soils with a clay content lower than threshold content (6–8%). Beyond threshold content, the influence of biochar appears to reduce. However, in the case of high sand content soils (90%), the NWC value on the drier side is generally higher as compared to soils with lower sand content. Based on sensitivity analysis, it was found that the ratio of fine to sand content is the most influential, while biochar content is the least influential.
The efficacy of Hybrid Hyrax-Mentoplate combination in early Class III treatment: a novel approach and pilot study
Authors: Katyal Vandana , Wilmes Benedict , Nienkemper Manuel , Darendeliler M. Ali , Sampson Wayne , Drescher Dieter 
Published: September 2021

Abstract

Introduction
The aim of the present study was to assess the skeletal, dental and soft tissue effects of a specific treatment protocol in consecutively treated patients who presented with a Class III malocclusion. Treatment involved the use of a Hybrid Hyrax (HH) in the maxilla, a Mentoplate in the mandible and the application of continuous intra-oral Class III elastics.

Method
The treated group was comprised of seven males and seven females (mean pretreatment age 10.4 ± 1.7 yr, range 7.8 – 12.9 yr). Treatment changes were analysed on lateral cephalograms taken 6–12 months prior to commencing treatment (T1) and at the finish of the orthopaedic phase (T2). Where a normality assumption was met, a parametric paired-sample t-test was used to assess the change differences at T1 and T2. For non-normal data, a non-parametric Wilcoxon sign rank test for related samples was used to assess T1 and T2 differences. The level of statistical significance was set at p < 0.05 (2-tailed).

Results
The average sagittal changes showed an improved SNA angle of 2.1 ± 2° (p = 0.002), an ANB angle of 1.9 ± 1.8° (p = 0.002), a Wits improvement of 3.4 ± 2.7 mm (p < 0.001) and an overjet reduction of 2.0 ± 2.2 mm (p = 0.005). There were no statistically significant correlations found between the age at T1, age at treatment start and age at T2 and the changes identified in the cephalometric variables (T2-T1).

Conclusion
The HH-Mentoplate Class III treatment protocol induced a mean Wits improvement of 3.4 mm in the maxillary and mandibular sagittal base relationship at the functional occlusal level. This was primarily achieved by sagittal maxillary skeletal protraction with negligible effects on the mandible, facial vertical dimension and the incisor angulations. A controlled clinical study with larger sample sizes and longer follow-up times is needed.
The effect of smiling on facial asymmetry in adults: a 3D evaluation
Authors: Darby Laura J. , Millett Declan T. , Kelly Niamh , McIntyre Grant T. , Cronin Michael S. 
Published: September 2021

Abstract

Background/aims
Mild resting facial asymmetry exists in clinically symmetrical faces, but the effect of smiling on the magnitude of overall facial asymmetry in adults has not been assessed. The aim of the present study was to use stereophotogrammetry to quantify the effect of smiling on overall facial asymmetry in Caucasian adults who presented with Class I incisor relationships and no history of orthodontic treatment.

Methods
Twenty male and 20 female Caucasians aged 18–30 years with no history of orthodontic treatment, a clinically symmetrical face and a Class I incisor relationship had 3D stereophotogrammetric images captured at rest and on natural and maximal smile (T1). The images were repeated 2–4 weeks later (T2) to assess expression reproducibility. Overall facial asymmetry scores were produced from 27 landmarks using partial Ordinary Procrustes Analysis (OPA) and assessed by an Analysis of Covariance (ANCOVA) model. A random sample of the images was re-examined two months later to calculate intraobserver landmark reproducibility.

Results
Mean landmark error was low (0.41 ± 0.07 mm). Mean overall facial asymmetry scores were not significantly gender different (p = 0.5300); therefore, the male and female data were pooled. Mean overall facial asymmetry scores for maximal (0.91 ± 0.16) and natural smile (0.88 ± 0.18) were higher than at rest (0.80 ± 0.17) (p < 0.0001) and were reproducible across (T1–T2) sessions (p = 0.3204).

Conclusions/implications
Overall 3D facial asymmetry scores for the sampled Caucasian adults with clinically symmetrical faces increased in magnitude from rest to natural and to maximal smile. Clinicians should assess overall facial asymmetry at rest and on natural and maximal smile at baseline, during treatment and as part of a core outcome assessment, particularly for cases with unilateral posterior crossbite, unilateral cleft lip and palate or skeletal asymmetry.
Some aspects of Financial Statements preparation in pharmaceutical industry
Authors: Домбровская Е.Н. , Фурман А.Ю. 
Published: September 2021

В статье приведены выводы по результатам анализа отчетности компаний фармацевтической отрасли, подготовленной по МСФО. Рассмотрены некоторые аспекты подготовки отчетности, которые необходимо принимать во внимание компаниям, осуществляющим деятельность по реализации фармацевтической продукции. Среди таких ключевых особенностей рассмотрен учет торговых скидок, их отражение в отчетности, учет запасов, в частности, формирование резервов по сроку годности, резервов под снижение стоимости товаров. Также предложены некоторые схемы по механизму формирования резервов, а также предоставления торговых скидок.
This article provides conclusions on the analysis of the IFRS reporting of pharmaceutical companies. This article discloses some aspects of the preparation of financial statements. Among these key features are trade discounts and their reflection in the reporting, inventory accounting, accounting for reserves for the shelf life, for the reduction in the cost of goods sold. Some schemes are proposed for the mechanism of forming reserves, providing trade discounts.
Impact of demographic processes on the regional economy
Authors: Абрамян Г.А. 
Published: September 2021

В статье проведена работа по описанию теоретико-методологической базы прогнозирования демографических процессов в контексте их влияния на социально-экономическое развитие территории, в частности, на промышленный сектор экономики. В проведенном исследовании были спрогнозированы значения объема отгруженных товаров собственного производства, выполненных работ и услуг собственными силами; среднегодовой численности занятых в экономике и производительности труда в Ростовской области к 2020 г. и 2030 г., а также представлен комплекс правительственных инициатив, направленных на улучшение демографической ситуации мерами социально-экономической политики. Актуальность статьи обусловлена тем, что в современных условиях одним из ключевых индикаторов качества управления регионом со стороны органов исполнительной власти является демографическая ситуация, формирующая человеческий капитал как основу экономического роста региона, и, как, следствие, его конкурентоспособности. Рассматриваемая в данной статье тема будет интересна, в первую очередь, специалистам, занимающимся демографической политики в региональных органах исполнительной власти, а также широкому кругу экономистов, изучающих вопросы социально-экономического развития.
The article describes the theoretical and methodological basis for forecasting demographic processes in the context of their impact on the socio-economic development of the territory, in particular, on the industrial sector of the economy. In the study, the values of the volume of shipped goods of own production, works and services performed on their own were predicted; the average annual number of people employed in the economy and labor productivity in the Rostov region by 2020 and 2030, as well as a set of government initiatives aimed at improving the demographic situation by means of socio-economic policy. The relevance of the article is due to the fact that in modern conditions one of the key indicators of the quality of regional management on the part of the executive authorities is the demographic situation, which forms human capital as the basis of economic the growth of the region, and, as a consequence, its competitiveness. The topic considered in this article will be useful for specialists involved in demographic policy in regional executive bodies, as well as to a wide range of economists studying issues of socio-economic development.
Analysis of time series using Big Data algorithms
Authors: Сотников А.И. 
Published: September 2021

То, с какой скоростью человечество накапливает информацию ежедневно, и непредсказуемость завтрашнего дня показывают, что для прогнозирования временных рядов больших данных уже не хватает традиционных технологий и необходимы новые методы обработки. В связи с этим встает вопрос, какие методы возможно использовать в настоящее время для получения достоверного прогнозирования временных рядов больших данных?
The speed at which humanity is accumulating information on a daily basis and the unpredictability of tomorrow show that traditional technologies are no longer enough for forecasting big data time series and new processing methods are needed. In this regard, the question arises, what methods can be used at present to obtain reliable forecasting of time series of big data?