bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting mitochondrial dysfunction with small molecules in intervertebral disc aging and degeneration
Authors: Saberi Morteza , Zhang Xiaolei , Mobasheri Ali 
Published: February 2021

AbstractThe prevalence of rheumatic and musculoskeletal diseases (RMDs) including osteoarthritis (OA) and low back pain (LBP) in aging societies present significant cost burdens to health and social care systems. Intervertebral disc (IVD) degeneration, which is characterized by disc dehydration, anatomical alterations, and extensive changes in extracellular matrix (ECM) composition, is an important contributor to LBP. IVD cell homeostasis can be disrupted by mitochondrial dysfunction. Mitochondria are the main source of energy supply in IVD cells and a major contributor to the production of reactive oxygen species (ROS). Therefore, mitochondria represent a double-edged sword in IVD cells. Mitochondrial dysfunction results in oxidative stress, cell death, and premature cell senescence, which are all implicated in IVD degeneration. Considering the importance of optimal mitochondrial function for the preservation of IVD cell homeostasis, extensive studies have been done in recent years to evaluate the efficacy of small molecules targeting mitochondrial dysfunction. In this article, we review the pathogenesis of mitochondrial dysfunction, aiming to highlight the role of small molecules and a selected number of biological growth factors that regulate mitochondrial function and maintain IVD cell homeostasis. Furthermore, molecules that target mitochondria and their mechanisms of action and potential for IVD regeneration are identified. Finally, we discuss mitophagy as a key mediator of many cellular events and the small molecules regulating its function.
Increased resilience for manufacturing systems in supply networks through data-based turbulence mitigation
Authors: Bauer Dennis , Böhm Markus , Bauernhansl Thomas , Sauer Alexander 
Published: February 2021

AbstractIn manufacturing systems, a state of high resilience is always desirable. However, internal and external complexity has great influence on these systems. An approach is to increase manufacturing robustness and responsiveness—and thus resilience—by manufacturing control. In order to execute an effective control method, it is necessary to provide sufficient information of high value in terms of data format, quality and time of availability. Nowadays, raw data is available in large quantities. An obstacle to manufacturing control is the short-term handling of events induced by customers and suppliers. These events cause different kinds of turbulence in manufacturing systems. If such turbulences could be evaluated in advance, based on data processing, they could serve as aggregated input data for a control system. This paper presents an approach how to combine turbulence evaluation and the derivation of measures into a learning system for turbulence mitigation. Integrated in manufacturing control, turbulence mitigation increases manufacturing resilience and strengthens the supply network’s resilience.
Energy-Based Devices for Functional Vaginal Problems: Issues and Answers
Authors: Bujnak Alyssa , Crowder Carly A. , Krychman Michael L. 
Published: February 2021

Abstract
Vaginal rejuvenation is a marketing term that encompasses surgical and medical treatments for functional vaginal/vulvar problems including but not limited to genitourinary syndrome of menopause (GSM), sexual dysfunction, vaginal laxity, and stress urinary incontinence (SUI) and for esthetic concerns including dissatisfaction with vulvovaginal appearance. Multiple treatment options have become available for indications of functional vaginal problems. Noninvasive management options including the use of more novel treatments such as energy-based devices have gained interest. Previously, studies regarding the efficacy and safety of the energy-based devices for functional vaginal problems were mostly limited to cohort studies without sham treatment, control groups, randomization, or double blinding. As a result of this insufficient data in 2018, the FDA released a statement of warning against the use of energy-based devices in the treatment of functional vaginal problems or vaginal cosmetic procedures (Https://Www.Fda.Gov/Medical-Devices/Safety-Communications/Fda-Warns-Against-Use-Energy-Based-Devices-Perform-Vaginal-Rejuvenation-or-Vaginal-Cosmetic. 1–4, 2018).

Purpose of Review
This article reviews the most current treatment modalities in the realm of vaginal rejuvenation therapy with an emphasis on the efficacy and safety of the energy-based devices.

Recent Findings
In the most recent literature, there have been studies with improvements in study design that support the efficacy and the short-term safety of the energy-based devices.

Summary
More recent studies with improved study design evidence that the use of energy-based devices results in improvements in functional vaginal problems and that serious adverse events appear to be rare. The availability of these devices as treatment options for functional vaginal problems has the potential to impact patient by improving their symptoms and quality of life. Caution still remains however regarding their safety following a longer period of time after their use.
SEOM clinical guidelines for the treatment of head and neck cancer (2020)
Authors: Mesia R. , Iglesias L. , Lambea J. , Martínez-Trufero J. , Soria A. , Taberna M. , Trigo J. , Chaves M. , García-Castaño A. , Cruz J. 
Published: February 2021

AbstractHead and neck cancers (HNC) are defined as malignant tumours located in the upper aerodigestive tract and represents 5% of oncologic cases in adults in Spain. More than 90% of these tumours have squamous histology. In an effort to incorporate evidence obtained since 2017 publication, the Spanish Society of Medical Oncology (SEOM) presents an update of the squamous cell HNC diagnosis and treatment guideline. Most relevant diagnostic and therapeutic changes from the last guideline have been updated: introduction of sentinel node biopsy in early oral/oropharyngeal cancer treated with surgery, concomitant radiotherapy with weekly cisplatin 40 mg/m2 in the adjuvant setting, new approaches for HPV-related oropharyngeal cancer and new treatments with immune-checkpoint inhibitors in recurrent/metastatic disease.
Perceived vulnerability to disease, knowledge about COVID-19, and changes in preventive behavior during lockdown in a German convenience sample
Authors: Stangier Ulrich , Kananian Schahryar , Schüller Johanna 
Published: February 2021

AbstractThe COVID-19 pandemic has called worldwide for strong governmental measures to contain its spread, associated with considerable psychological distress. This study aimed at screening a convenience sample in Germany during lockdown for perceived vulnerability to disease, knowledge about COVID-19, symptoms of depression and anxiety, and behavioral responses. In an online survey, 1358 participants completed the perceived vulnerability to disease scale (PVD), the Patient Health Questionnaire (PHQ-4), and questionnaires on knowledge about COVID-19 and self-perceived change in behaviors in response to COVID-19. Lower and upper quartiles of the PVD were used to classify individuals into low and high PVD. A confirmatory factor analysis supported three factors representing risk, preventive and adaptive behavior as behavioral responses to COVID-19 lockdown. A structural equation model showed that the score of the knowledge scale significantly predicted the self-reported increase in adaptive and preventive behavior. The score in the PVD-subscale Perceived Infectability predicted a self-reported increase in preventive behavior, whereas the Germ Aversion score predicted a self-reported increase in preventive and a decrease in risk behavior. The score in PHQ-4 predicted a higher score in the perceived infectability and germ aversion subscales, and a self-reported decrease in adaptive behavior. Low-, medium- and high-PVD groups reported distinct patterns of behavior, knowledge, and mental health symptoms. This study shows that perceived vulnerability to disease is closely linked to preventive behaviors and may enhance adaptation to COVID-19 pandemic.
Engaging Teachers and School Leaders in Participatory Data Analysis for the Development of a School-Based Mental Health Intervention
Authors: Neill Ruth D. , Best Paul , Lloyd Katrina , Williamson Janet , Allen Jack , Badham Jennifer , Tully Mark. A. 
Published: February 2021

AbstractThe success of school-based mental health interventions is often inconsistent, in part due to lack of input from teachers and students in the programme design. Therefore, the involvement and engagement of teachers in the co-production of an intervention, especially within data analysis, can create more innovative and effective solutions. This paper presents a teacher-led qualitative data analysis using a new approach within the field, participation theme elicitation. This approach will be used to gather information relevant to the initial development of a school-based mental health intervention. Teachers identified the following themes: (1) physical activity as a stress reliever, (2) programme facilitation, (3) exam pressure and (4) solutions to improve negative mental health. Results from the teacher-led analysis are broadly similar to previous research in the field. Our findings demonstrate that teachers can have a valuable input into research findings which should help address the development of a school-based mental health intervention. In summary, the findings suggest that the use of participatory theme elicitation is a valid and effective method to address the gaps and limitations of participatory qualitative data analysis.
Dried urine spots as sampling technique for multi-mycotoxin analysis in human urine
Authors: Schmidt Jessica , Lindemann Viktoria , Olsen Monica , Cramer Benedikt , Humpf Hans-Ulrich 
Published: February 2021

AbstractA simple and effective approach for HPLC-MS/MS based multi-mycotoxin analysis in human urine samples was developed by application of dried urine spots (DUS) as alternative on-site sampling strategy. The newly developed method enables the detection and quantitation of 14 relevant mycotoxins and mycotoxin metabolites, including citrinin (CIT), dihydrocitrinone (DH-CIT), deoxynivalenol (DON), fumonisin B1 (FB1), T-2 Toxin (T-2), HT-2 Toxin (HT-2), ochratoxin A (OTA), 2′R-ochratoxin A (2′R-OTA), ochratoxin α (OTα), tenuazonic acid and allo-tenuazonic acid (TeA + allo-TeA), zearalenone (ZEN), zearalanone (ZAN), α-zearalenol (α-ZEL), and β-zearalenol (β-ZEL). Besides the spotting procedure, sample preparation includes enzymatic cleavage of glucuronic acid conjugates and stable isotope dilution analysis. Method validation revealed low limits of detection in the range of pg/mL urine and excellent apparent recovery rates for most analytes. Stability investigation of DUS displayed no or only slight decrease of the analyte concentration over a period of 28 days at room temperature. The new method was applied to the analysis of a set of urine samples (n = 91) from a Swedish cohort. The four analytes, DH-CIT, DON, OTA, and TeA + allo-TeA, could be detected and quantified in amounts ranging from 0.06 to 0.97 ng/mL, 3.03 to 136 ng/mL, 0.013 to 0.434 ng/mL and from 0.36 to 47 ng/mL in 38.5%, 70.3%, 68.1%, and 94.5% of the samples, respectively. Additional analysis of these urine samples with an established dilute and shoot (DaS) approach displayed a high consistency of the results obtained with both methods. However, due to higher sensitivity, a larger number of positive samples were observed using the DUS method consequently providing a suitable approach for human biomonitoring of mycotoxin exposure.
Do adults with non-communicable diseases meet the German physical activity recommendations?
Authors: Sudeck Gorden , Geidl Wolfgang , Abu-Omar Karim , Finger Jonas David , Krauß Inga , Pfeifer Klaus 
Published: February 2021

Abstract
Introduction
The numerous health benefits of physical activity (PA) for people with non-communicable diseases (NCDs) are well-documented. In Germany, there are limited data on whether adults with NCDs fulfill health-oriented PA recommendations. This study describes the prevalence of meeting PA recommendations among adults with select NCDs.

Method
Based on the national representative GEDA-2014/2015-EHIS (N = 24,016), the self-reported PA data of the European Health Interview Survey–Physical Activity Questionnaire (EHIS-PAQ) were classified with respect to fulfilling recommendations for health-enhancing aerobic activities (≥ 150 min per week with at least moderate intensity) and muscle strengthening (≥ 2 times per week). These binary indicators were used to analyze the association between the prevalence of sufficient PA and the self-reported presence of certain NCDs and multiple NCDs to reflect multimorbidity.

Results
Compared to the general adult population, sufficient aerobic PA was lower for most NCDs, with the lowest level among people with diabetes mellitus, obesity, stroke, chronic obstructive pulmonary disease (COPD), and depression. Compared to the general adult population, sufficient muscle strengthening was lower for some NCDs (diabetes mellitus, obesity, depression), but it was higher in people with musculoskeletal diseases (osteoarthritis, lower back pain). Multimorbidity was negatively associated with sufficient PA levels.

Conclusion
The study specifies the need to promote PA among adults with select NCDs to counteract insufficient levels of health-enhancing PA and to reduce the individual and societal burden of NCDs.
Nasal Septal Deviation After Surgically Assisted Rapid Maxillary Expansion
Authors: Seidita Francesco , de Azambuja Carvalho Pedro Henrique , Dos Sántos José Cleveilton , Dell’Aversana Orabona Giovanni , Califano Luigi , Gabrielli Mário Francisco Real , Filho Valfrido Antonio Pereira 
Published: February 2021

Abstract
Background and Aim
Surgically assisted rapid maxillary expansion (SARME) is a surgical technique widely used to correct deficiency of the transverse maxillary dimension. Although some studies investigated the effect of SARME on nasal and facial alterations, there is no evidence that correlates nasal septal deviation (NSD) to SARME as a possible postoperative sequel. The aim of this study is to address and quantify possible variations in the position of the nasal bony septum after SARME and identify any NSD as a postoperative outcome of this surgical technique.

Patients and Methods
This is a retrospective study, conducted at the Department of Oral and Maxillofacial Surgery of the University Hospital of Araraquara (Unesp, faculty of dentistry), SP, Brazil. Twenty-nine patients who underwent SARME were studied; every patient was evaluated by cone-beam computerized tomography (CBCT) before (T0) and six months after surgery (T1), and we collected the variation of nasal septal position by measuring the distance between the bony septum and the nasal lateral wall. Our measurements were carried out at the level of the head, midpoint and tail of the inferior turbinate.

Results
A mean NSD ranging from 0.4 to 1.2 mm was measured, and it is more pronounced at the anterior part of the bony septum. Twenty-seven patients (93.1%) presented minor changes in bony septum position; in 2 cases (6.8%), a significant NSD was found (p < 0.05).

Conclusion
A variation of bony nasal septum position can be expected in any direction after SARME, and it is more pronounced at anterior portion.
Angiographic evaluation of radial artery injury after transradial approach for percutaneous coronary intervention
Authors: Kanazawa Takenori , Shimamura Kiyotaka , Nagao Kazuya , Yukawa Hiroshi , Aida Kenji , Kobayashi Yohei , Takahashi Naoki , Nakagawa Eiichiro , Itoh Haruyasu , Hayashi Fujio , Makita Toshinori , Tanaka Masaru , Inada Tsukasa 
Published: February 2021

AbstractThe transradial approach for percutaneous coronary intervention (TRA-PCI) has been increasingly gaining popularity in clinical practice. However, its association with risk for long-term radial artery injury has not been yet thoroughly defined. We retrospectively examined the patients undergoing radial artery angiography (RAG) after TRA-PCI to determine the incidence and risk factors of radial artery injury. The study included 558 patients undergoing follow-up radial artery angiography at 12 month after TRA-PCI. Radial artery injury occurred in 140 patients (25%) with 3 distinct morphological patterns: focal radial artery stenosis (RAS) P.7,7: in 7 patients (1%), diffuse radial artery stenosis (RAS) in 78 patients (14%), and radial artery occlusion (RAO) in 55 patients (10%). Patients with RAS/RAO were more likely to be female, had smaller height and body weight, smaller body mass index and smaller body surface area (BSA) as compared with those without RAS/RAO. Multivariable logistic regression analysis identified BSA (odds ratio, 1.34 per 0.1 m2 increase; 95% confidence interval, 1.07–1.71; p = 0.01) and a history of TRA-PCI (odds ratio, 2.35; 95% confidence interval, 1.16–5.08; p = 0.017) as independent predisposing factors of radial artery injury. In a sub-analysis of 323 patients undergoing both pre-PCI RAG and follow-up RAG, pre-PCI radial diameter as well as BSA and a history of TRA-PCI were independently associated with radial artery injury. Long-term injury after TRA-PCI is considerably common and care should be paid for RAS/RAO, especially for those patients with lower BSA, history of TRA-PCI and small radial artery diameter.
Multiple attribute group decision-making based on cubic linguistic Pythagorean fuzzy sets and power Hamy mean
Authors: Xu Wuhuan , Shang Xiaopu , Wang Jun 
Published: February 2021

AbstractThe linguistic Pythagorean fuzzy sets (LPFSs), which employ linguistic terms to express membership and non-membership degrees, can effectively deal with decision makers’ complicated evaluation values in the process of multiple attribute group decision-making (MAGDM). To improve the ability of LPFSs in depicting fuzzy information, this paper generalized LPFSs to cubic LPFSs (CLPFSs) and studied CLPFSs-based MAGDM method. First, the definition, operational rules, comparison method and distance measure of CLPFSs are investigated. The CLPFSs fully adsorb the advantages of LPFSs and cubic fuzzy sets and hence they are suitable and flexible to depict attribute values in fuzzy and complicated decision-making environments. Second, based on the extension of power Hamy mean operator in CLPFSs, the cubic linguistic Pythagorean fuzzy power average operator, the cubic linguistic Pythagorean fuzzy power Hamy mean operator as well as their weighted forms were introduced. These aggregation operators can effectively and comprehensively aggregate attribute values in MAGDM problems. Besides, some important properties of these operators were studied. Finally, we presented a new MAGDM method based on CLPFSs and their aggregation operators. Illustrative examples and comparative analysis are provided to show the effectiveness and advantages of our proposed decision-making method.
Experimental study of the dust-removal performance of a wet scrubber
Authors: Hu Shengyong , Gao Yang , Feng Guorui , Hu Fei , Liu Changhe , Li Jihua 
Published: February 2021

AbstractA variety of dust control methods are often applied in coal mines, among which the application of wet scrubbers has proven to be an efficient technology for the removal of dust in airstreams, rather than diluting or confining the dust. In this paper, a wet scrubber design was developed. Based on a self-designed experimental test platform, the total dust concentration, respirable dust concentration, air volume, and average pressure drops of wet scrubbers with 12, 16, 20, and 24 blades were measured under different water intake conditions. The results show that the different water intake levels have only minimal effects on the air volume of the wet scrubbers. However, increased water intake had improved the dust removal efficiency of the wet scrubbers with the same number of blades. The wet scrubber with 16 blades was found to have the best dust removal efficiency at a water intake level of 1.35 m3/h. Its total dust and respirable dust removal efficiency reached 96.81% and 95.59%, respectively. The air volume was 200.4 m3/min, and the average pressure drop was determined to be 169.4 Pa. In addition, when the wet scrubber with 16 blades was applied in a coal preparation plant in China’s Shanxi Province, it was observed that the total dust concentration had fallen below 8.1 mg/m3, and the respirable dust concentration had fallen below 5.9 mg/m3. Therefore, the results obtained in this research investigation provide important references for the use of wet scrubbers to improve coal production environmental conditions.
Suramin enhances the urinary excretion of VEGF-A in normoglycemic and streptozotocin-induced diabetic rats
Authors: Chyła Gabriela , Sałaga-Zaleska Kornelia , Dąbkowski Kamil , Kuchta Agnieszka , Jankowski Maciej 
Published: February 2021

Abstract
Background
Vascular endothelial growth factor A (VEGF-A) and P2-receptors (P2Rs) are involved in the pathogenesis of diabetic nephropathy. The processing of VEGF-A by matrix metalloproteinases (MMP) regulates its bioavailability. Since the ATP-induced release of MMP-9 is mediated by P2Rs, we investigated the effect of suramin on VEGF-A excretion in urine and the urinary activity of total MMP and MMP-9.

Methods
The effect of suramin (10 mg/kg, ip) on VEGF-A concentration in serum and its excretion in urine was investigated in streptozotocin (STZ)-induced diabetic rats over a 21-day period. The rats received suramin 7 and 14 days after a single STZ injection (65 mg/kg, ip). A 24-h collection of urine was performed on the day preceding the administration of STZ and the first administration of suramin and on the day before the end of the experiment. The VEGF-A in serum and urine, albumin in urine, and total activity of MMP and MMP-9 in urine were measured using immunoassays.

Results
Diabetic rats are characterized by a sixfold higher urinary excretion of VEGF-A. Suramin potentiates VEGF-A urinary excretion by 36% (p = 0.046) in non-diabetic and by 75% (p = 0.0322) in diabetic rats but it did not affect VEGF-A concentration in the serum of non-diabetic and diabetic rats. Urinary albumin excretion as well as total MMP and MMP-9 activity was increased in diabetic rats, but these parameters were not affected by suramin.

Conclusion
Suramin increases the urinary excretion of VEGF-A in normoglycemia and hyperglycaemia, possibly without the involvement of MMP-9. Suramin may be used as a pharmacological tool enhancing VEGF-A urinary secretion.
The Change of Judicial Power in China in the Era of Artificial Intelligence
Authors: JI Weidong 
Published: February 2021

AbstractThe singularity of artificial intelligence (AI), which transcends human intelligence to play the role of God, is imminent. In this context, the Chinese judicial system has gained some latecomer advantage, with the help of information technology, the Internet, big data, cloud computing, and AI to improve the efficiency and transparency of case handling. The trial process has undergone extensive and profound qualitative mutations. This represents a challenge to the institutional arrangements of the modern rule of law. At this stage, we should adopt a cautious and prudent attitude towards the design and application of legal-expert systems as well as machine learning. Especially from the aspect of computer sentencing, it is even more necessary to avoid a rush for quick results, and there is no need to completely exclude the judge’s discretion and free evaluation of the evidence through inner conviction. The finality of the judicial power is destined to choose a correct final solution through a debate on the survival of the fittest mechanism. In the face of such a modern rule-of-law system, big data, cloud computing, information technology, and AI are just auxiliary means to achieve legal justice. It is impossible to put the cart before the horses. This is a basic principle that we should always bear in mind.