bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coastal zone management of Passo Village of Ambon Municipal, Indonesia
Authors: Retraubun A S W , Selanno D A J , Siahainenia L , Tubalawony S , Chr Tuhumury N , Sandhy D A 
Published: July 2021

AbstractThe increasing population number in Ambon City and the fulfillment of their needs drive an increase in environmental degradation. Spatial mismanagement of the Ambon municipal area is one of the causes behind environmental degradation. The objective of this study is to analyze the structure and utilization pattern of the coastal zone of Passo Village and propose an appropriate coastal zone management strategy for Passo Village of Ambon City. The study was conducted between August to October 2020 at the Village of Passo. Data on spatial structure and pattern was gathered through direct observation, interviews, and a close questionnaire distributed to respondents. Secondary data were obtained through a literature review related to the research topic. Spatial structure and pattern utilization data were collected through observation within the spatial coastal zone. The data were then analyzed with ArcGis 10.3 software. Map of spatial structure and pattern of Passo Village obtained was then compared to a basic map, Spatial Detail Plan of Passo, and Ambon Regional Spatial Plan document. Strategic management analysis was done through the SWOT method. The result shows that the spatial structure of Passo Village consists of infrastructure (125.54 ha), transportation and communication lines (1.27 ha). The settlement area coverage of Passo Village occupies about 91.5% of the total spatial structure. The spatial pattern of Passo Village consists of a protected area (85.53 ha) and a cultivation area (165.90 ha). Based on SWOT analysis, seven management strategies were proposed for Passo Village spatial coastal management.
Investigation on different approaches for detecting polymer content in styrene-butadiene-styrene modified asphalt
Authors: Xu Song , Huang Jinming , Que Yun , Ke Yunbin , Fan Yong , Zhang Canlin , Feng Zhengang 
Published: July 2021

Abstract
This paper investigates three approaches for detecting the content of styrene-butadiene-styrene (SBS) in its modified asphalt. The physical, rheological, and structural analysis are respectively conducted by the conventional tests, dynamic shear rheology, and Fourier transform infrared spectroscopy (FTIR) tests. The results show that the fitting coefficient of the quadratic equation between the SBS content and viscosity or softening point or phase angle is very high, but these tests are time-consuming. The absorption peak at 966 cm-1 (the absorption peak area of 966 cm-1 is marked as A966, the same below) is selected as the characteristic peak of SBS, and the absorption peaks of 1377 cm-1, 811 cm-1 and 749 cm-1 are selected as the characteristic peak of the base asphalt in SBS modified asphalt. Comparing the applicability, accuracy and sensitivity of A966/A1377, A966/A811, and A966/A749, it is found that A966/A811 is more suitable as the indicator to determine the content of SBS. FTIR can realize the rapid and accurate detection of SBS content. Furthermore, A966/A811 has a good quadratic relationship with the performance of the modified asphalt.
William Oldroyd’sLady Macbeth, Shakespeare, and Adaptation Studies
Authors: Semenza Greg M Colón 
Published: July 2021

AbstractThe title of Oldroyd’s taut thriller, Lady Macbeth (2016), invites audiences to approach the film intertextually. For a small number of viewers familiar with Nikolai Leskov’s 1865 novella Lady Macbeth of Mtsensk, from which the film draws its main inspiration, Shakespeare’s more well-known character will recede into a position of secondary importance. For the majority of viewers, however, a more direct relationship with Shakespeare will be assumed: is Oldroyd’s film an adaptation of the 1606 play? Is it an appropriation of the play’s famous character? Although such questions about an artwork’s relationship to previous texts can seem largely academic, in the case of Oldroyd’s film, they might reasonably be said to be inevitable and, therefore, potentially central to the work’s meaning. Adaptation scholars often struggle to classify such cases—since the line between what we call adaptations and what we call appropriations remains somewhat blurry. The essay uses Oldroyd’s Lady Macbeth as a practical tool for working through what is at stake in these ‘academic’ or ‘semantic’ debates about the frustrating varieties of textual adaptation. The larger intertextual history of Lady Macbeth illustrates the manner in which our critical debates about adaptation tend to reflect, and inform, our deepest desires for and anxieties about progress—or perhaps, more accurately, the apparent lack of such progress—from one historical moment to the next. In doing so, such debates almost mimic the trajectory and functions of adaptations themselves, helping us to understand better why definitions of adaptation must remain elastic and manifold.
The thickening and modification of the galactan-enriched layer during primary phloem fibre development in Cannabis sativa
Authors: Kim Eun-Soo , Choi Wonkyun , Park Sang-Hyuck 
Published: July 2021

Abstract
Primary phloem fibres (PPFs) have higher fibre quality and are economically more important for the textile sector than secondary phloem fibres. Both the chemical composition and mechanical structure of the secondary cell wall mainly influence the quality of bast fibres. We investigated the thickening of the galactan-enriched (Gn) layer and its modification process into a gelatinous (G)-layer, which is the largest portion of the secondary cell wall, during the development of the PPF in Cannabis sativa. Stem segments of hemp collected at 17, 29, 52 and 62 days after sowing were comparatively examined using light microscopy, scanning electron microscopy and transmission electron microscopy. The initial cells of PPF started the proliferation and differentiation at 17 days, but the secondary cell wall thickening had already commenced before the 29 days. Both the G- and Gn-layer were rapidly added onto the S-layer of PPFs; thus, the secondary cell wall thickness increased approximately 2-fold at 52 days (from the 29-day mark), and 8-fold at 62 days. The cortical microtubule arrays appeared adjacent to the plasma membrane of PPF cells related to the cellulose synthesis. Additionally, cross-sectioned microfibrils were observed on Gn-layer as the cluster of tiny spots. At 62 days, the specific stratification structure consisting of several lamellae occurred on the G-layer of the secondary cell wall. The secondary cell wall thickened remarkably at 52 days through 62 days so that the mature secondary cell wall consisted of three distinctive layers, the S-, G- and Gn-layer. Cortical microtubule arrays frequently appeared adjacent to the plasma membrane together with cellulose microfibrils on secondary cell wall. The G-layer of PPF at 62 days exhibited the characteristic stratification structure, which demonstrates the modification of the Gn-layer into the G-layer.
Hymen Restoration: An Experience From a Moroccan Center
Authors: Lahlali Abdelilah , Sawan Dana , SidAhmed-Mezi Mounia , Meningaud Jean-Paul , Hersant Barbara 
Published: July 2021

Abstract

Background
Hymenoplasty is one of the least described vulvovaginal procedures in plastic surgery without any surgical standard that attempts to restore the hymen’s ability to bleed during sexual intercourse on a couple’s wedding night.

Objectives
The objective of this study was to report outcomes from a Moroccan retrospective study of a series of 529 patients who underwent either a hymenorrhaphy or a hymenoplasty.

Methods
This was a retrospective study of 529 patients who underwent hymen restoration at a center in Morocco between April 2010 and April 2019. The data were collected according to the requirements of the center through preoperative and postoperative consultations and in-person or phone post-coital interviews. The procedure consisted of suturing the edges of the hymen remnants with Vicryl 5-0, leaving a small opening in the newly reconstructed hymen. Two techniques—hymenal flap hymenoplasty and vaginal flap hymenoplasty—were employed depending on the presence or absence of hymen remnants.

Results
A total of 529 patients underwent hymen restoration, including 42% hymenorrhaphies, 58% hymenoplasties, 39% hymenal flap hymenoplasty, and 19% vaginal flap hymenoplasty. The mean age of the patients was 32 years. Of the 227 women who underwent a hymenorrhaphy, no failure was reported, and all the patients who had sexual intercourse within 15 days of the procedure experienced vaginal bleeding. Of the 99 hymenoplasties employing vaginal flaps, only 1 failure was reported.

Conclusions
The techniques utilized in our cohort are safe and the complications are minor with general satisfaction of patients.

Level of Evidence: 4
Sixty years of forensic seismology at AWE Blacknest
Authors: Green David , Heyburn Ross , Keeble Jessica , Nippress Alexandra , Nippress Stuart , Peacock Sheila , Young John 
Published: July 2021

Abstract
David Green, Ross Heyburn, Jessica Keeble, Alexandra Nippress, Stuart Nippress, Sheila Peacock and John Young review the history of the UK's seismological monitoring of underground nuclear testing
Drug sensitivity prediction from cell line-based pharmacogenomics data: guidelines for developing machine learning models
Authors: Sharifi-Noghabi Hossein , Jahangiri-Tazehkand Soheil , Smirnov Petr , Hon Casey , Mammoliti Anthony , Nair Sisira Kadambat , Mer Arvind Singh , Ester Martin , Haibe-Kains Benjamin 
Published: July 2021

AbstractThe goal of precision oncology is to tailor treatment for patients individually using the genomic profile of their tumors. Pharmacogenomics datasets such as cancer cell lines are among the most valuable resources for drug sensitivity prediction, a crucial task of precision oncology. Machine learning methods have been employed to predict drug sensitivity based on the multiple omics data available for large panels of cancer cell lines. However, there are no comprehensive guidelines on how to properly train and validate such machine learning models for drug sensitivity prediction. In this paper, we introduce a set of guidelines for different aspects of training gene expression-based predictors using cell line datasets. These guidelines provide extensive analysis of the generalization of drug sensitivity predictors and challenge many current practices in the community including the choice of training dataset and measure of drug sensitivity. The application of these guidelines in future studies will enable the development of more robust preclinical biomarkers.
CoSMeD: a user-friendly web server to estimate 5-year survival probability of left-sided and right-sided colorectal cancer patients using molecular data
Authors: Xin Junyi , Wu Yanling , Ben Shuai , Li Shuwei , Chu Haiyan , Wang Meilin , Wang Molin , Song Mingyang , Du Mulong , Zhang Zhengdong 
Published: July 2021

Abstract

Summary
Colorectal cancer is a heterogeneous disease with diverse prognoses between left-sided and right-sided patients; therefore, it is necessary to precisely evaluate the survival probability of side-specific colorectal cancer patients. Here, we collected multi-omics data from The Cancer Genome Atlas program, including gene expression, DNA methylation and microRNA expression. Specificity measure and robust likelihood-based survival analysis were used to identify 6 left-sided and 28 right-sided prognostic biomarkers. Compared to the performance of clinical prognostic models, the addition of these biomarkers could significantly improve the discriminatory ability and calibration in predicting side-specific 5-year survival for colorectal cancer. Additional dataset derived from Gene Expression Omnibus was used to validate the prognostic value of side-specific genes. Finally, we constructed colorectal cancer side-specific molecular database (CoSMeD), a user-friendly interface for estimating side-specific colorectal cancer 5-year survival probability, which can lay the basis for personalized management of left-sided and right-sided colorectal cancer patients.

Availability and implementation
CoSMeD is freely available at https://mulongdu.shinyapps.io/cosmed.

Supplementary information
Supplementary data are available at Bioinformatics online.
HDAC1: an environmental sensor regulating endothelial function
Authors: Dunaway Luke S , Pollock Jennifer S 
Published: July 2021

Abstract
The histone deacetylases (HDACs) are a family of enzymes that catalyse lysine deacetylation of both histone and non-histone proteins. Here, we review, summarize, and provide perspectives on the literature regarding one such HDAC, HDAC1, in endothelial biology. In the endothelium, HDAC1 mediates the effects of external and environmental stimuli by regulating major endothelial functions such as angiogenesis, inflammatory signalling, redox homeostasis, and nitric oxide signalling. Angiogenesis is most often, but not exclusively, repressed by endothelial HDAC1. The regulation of inflammatory signalling is more complex as HDAC1 promotes or suppresses inflammatory signalling depending upon the environmental stimuli. HDAC1 is protective in models of atherosclerosis where loss of HDAC1 results in increased cytokine and cell adhesion molecule (CAM) abundance. In other models, HDAC1 promotes inflammation by increasing CAMs and repressing claudin-5 expression. Consistently, from many investigations, HDAC1 decreases antioxidant enzyme expression and nitric oxide production in the endothelium. HDAC1 decreases antioxidant enzyme expression through the deacetylation of histones and transcription factors, and also regulates nitric oxide production through regulating both the expression and activity of nitric oxide synthase 3. The HDAC1-dependent regulation of endothelial function through the deacetylation of both histone and non-histone proteins ultimately impacts whole animal physiology and health.
Recent progress toward the implementation of phage therapy in Western medicine
Authors: Pirnay Jean-Paul , Ferry Tristan , Resch Grégory 
Published: July 2021

ABSTRACT
Like the sword of Damocles, the threat of a post-antibiotic era is hanging over humanity's head. The scientific and medical community is thus reconsidering bacteriophage therapy (BT) as a partial but realistic solution for treatment of difficult-to-eradicate bacterial infections. Here, we summarize the latest developments in clinical BT applications, with a focus on developments in the following areas: (i) pharmacology of bacteriophages of major clinical importance and their synergy with antibiotics; (ii) production of therapeutic phages; and (iii) clinical trials, case studies and case reports in the field. We address regulatory concerns, which are of paramount importance insofar as they dictate the conduct of clinical trials, which are needed for broader BT application. The increasing amount of new available data confirms the particularities of BT as being innovative and highly personalized. The current circumstances suggest that the immediate future of BT may be advanced within the framework of national BT centers in collaboration with competent authorities, which are urged to adopt incisive initiatives originally launched by some national regulatory authorities.
The Evolutionary Origins of Extreme Halophilic Archaeal Lineages
Authors: Feng Yutian , Neri Uri , Gosselin Sophia , Louyakis Artemis S , Papke R Thane , Gophna Uri , Gogarten Johann Peter 
Published: July 2021

AbstractInterest and controversy surrounding the evolutionary origins of extremely halophilic Archaea has increased in recent years, due to the discovery and characterization of the Nanohaloarchaea and the Methanonatronarchaeia. Initial attempts in explaining the evolutionary placement of the two new lineages in relation to the classical Halobacteria (also referred to as Haloarchaea) resulted in hypotheses that imply the new groups share a common ancestor with the Haloarchaea. However, more recent analyses have led to a shift: the Nanohaloarchaea have been largely accepted as being a member of the DPANN superphylum, outside of the euryarchaeota; whereas the Methanonatronarchaeia have been placed near the base of the Methanotecta (composed of the class II methanogens, the Halobacteriales, and Archaeoglobales). These opposing hypotheses have far-reaching implications on the concepts of convergent evolution (distantly related groups evolve similar strategies for survival), genome reduction, and gene transfer. In this work, we attempt to resolve these conflicts with phylogenetic and phylogenomic data. We provide a robust taxonomic sampling of Archaeal genomes that spans the Asgardarchaea, TACK Group, euryarchaeota, and the DPANN superphylum. In addition, we assembled draft genomes from seven new representatives of the Nanohaloarchaea from distinct geographic locations. Phylogenies derived from these data imply that the highly conserved ATP synthase catalytic/noncatalytic subunits of Nanohaloarchaea share a sisterhood relationship with the Haloarchaea. We also employ a novel gene family distance clustering strategy which shows this sisterhood relationship is not likely the result of a recent gene transfer. In addition, we present and evaluate data that argue for and against the monophyly of the DPANN superphylum, in particular, the inclusion of the Nanohaloarchaea in DPANN.
Associations Between Recently Diagnosed Conditions and Hospitalization due to COVID-19 in Patients Aged 50 Years and Older—A SHARE-Based Analysis
Authors: López-Bueno Rubén , Torres-Castro Rodrigo , Koyanagi Ai , Smith Lee , Soysal Pinar , Calatayud Joaquín 
Published: July 2021

Abstract

Background
Only a few studies have been carried out with a large sample size on the relationship between chronic conditions and hospitalization for coronavirus disease 2019 (COVID-19), and there is no research examining recently diagnosed conditions. Our purpose was to evaluate this association in a large sample including the older population from Europe and Israel.

Method
Data from the Survey of Health, Ageing and Retirement in Europe COVID-19 Survey, a representative survey of individuals aged 50 or older residing in 27 European countries and Israel, were retrieved. Associations between recently diagnosed chronic conditions (ie, conditions detected over the last 3 years) (exposure) and hospitalization due to COVID-19 (outcome) were assessed using multivariable logistic regression.

Results
A total of 51 514 participants on average 71.0 (SD = 9.2) years old were included. Participants with multimorbidity (ie, 2 or more recently diagnosed conditions) had significantly higher odds for COVID-19 hospitalization (adjusted odds ratio [AOR] = 3.91 [95% CI = 2.14–7.12]). Independent conditions such as lung disease (AOR = 16.94 [95% CI = 9.27–30.95]), heart disease (AOR = 3.29 [95% CI = 1.50–7.21]), or cancer (AOR = 3.45 [95% CI = 1.26–9.48]) showed particularly high odds for hospitalization due to COVID-19.

Conclusions
People with recently diagnosed diseases, and in particular those having lung disease, heart disease, or cancer, were significantly more likely to be hospitalized for COVID-19.
Postoperative complications and perioperative management of lung resection in patients with a history of oesophagectomy for oesophageal carcinoma
Authors: Watanabe Yukio , Hattori Aritoshi , Nojiri Shuko , Fukui Mariko , Matsunaga Takeshi , Takamochi Kazuya , Oh Shiaki , Suzuki Kenji 
Published: July 2021

Abstract OBJECTIVESAdvances in chemoradiation have improved the long-term prognosis of oesophageal cancer, although perioperative management for lung resection postoesophagectomy is unknown. The purpose of this study was to investigate postoperative complications and perioperative management for lung resection postoesophagectomy.METHODSBetween 2002 and 2017, a total of 4694 patients underwent lung resections; of these, 79 were performed postoesophagectomy. Using propensity score matching, we analysed postoperative complications between groups with and without postoesophagectomy lung resection. We also investigated the risk factors of Clavien–Dindo classification grade ≥2 complications by logistic regression analysis.RESULTSSixty-nine of the patients were men with a median age of 67 years. The types of lung resections were as follows: lobectomy in 34, segmentectomy in 12 and wedge resection in 33 patients. Postoperative complications were detected in 35 patients, including grade ≥2 complications in 24. After matching, aspiration pneumonia (P = 0.09) tended to be common in the postoesophagectomy group. Until 2008, non-fasting management before lung resection was performed in all 31, and intraoperative aspiration pneumonia was detected in 2 patients. After switching to fasting management before lung resection, there were no cases of intraoperative aspiration pneumonia. Multivariable analysis revealed that lung resection ipsilateral to oesophagectomy (P = 0.04) and lobectomy (P = 0.03) were predictors of grade ≥2 morbidity.CONCLUSIONSPatients having a lung resection postoesophagectomy tended to have a higher risk of aspiration pneumonia. Fasting management before lung resection is important in preventing intraoperative aspiration pneumonia. Lung resection ipsilateral to oesophagectomy and lobectomy may result in complications requiring therapeutic intervention.
Between Martyrdom and Silence: Dissent, Duress, and Persecution as the Suppression of Human Rights under the Refugee Convention
Authors: Wilsher Daniel 
Published: July 2021

Abstract
A real risk of death, torture, violence, or arbitrary detention is generally sufficient to satisfy ‘persecution’ under the Refugee Convention. Where, however, physical harm will only arise if a claimant were to exercise certain human rights upon return, jurisprudential uncertainty reigns. Only a few individuals are impelled to become ‘martyrs’ through open dissent. Courts strongly endorse these dissenters’ entitlement to international protection even if they could avoid retribution through self-censorship. A second group – ‘a silent minority’ – are those who would actually refrain from exercising their rights to avoid physical harm. Most jurisprudence appears to accept that such a situation may sometimes amount to persecution. Unlike martyrs, however, these claimants are required to meet control devices based upon the severity of the human rights restriction, and/or the mental effects of self-censorship on the claimant. These are, however, both arbitrary and unprincipled. This article argues the real harm felt by martyrs and the silent minority is the same: the forcible suppression of their enjoyment of human rights. Importantly, the United Nations High Commissioner for Refugees’ approach to military service, religious, and sexuality cases already embodies this principle. To generalize, this ‘suppressive’ persecution arises when (a) claimants sincerely wish to engage in actions which (b) are international human rights entitlements and (c) they face objective conditions of sufficient duress such that they cannot reasonably assert their rights through civil disobedience. When States or private actors suppress the exercise of rights by duress in this way, those affected suffer a denial of rights amounting to persecution. This analysis should apply whether a claimant would be a martyr or would be intimidated into self-censorship.