APPLICATION OF LUTEIN-ZEAXANTHIN OF EGG YOLK BASED HYDROGEL EYE MASK AS A PREVENTIVE EFFORT AGAINST COMPUTER VISION SYNDROME (CVS)
Authors: H Hamsinah , Meylinda Amelia , K Khusnia , Mario Rio , Ummum Andi , Safitri Dewi 
Published: November 2021

Aims and objectives: Computer Vision Syndrome(CVS) is a collection of symptoms related to eye disorders due to the use of computer-based digital devices. So substantial protection is needed against damage caused by exposure to blue light by digital devices. Lutein and zeaxanthin are carotenoids that contain antioxidants so that they can overcome inflammation, have a calming effect and can maintain eye health. The purpose of this research is to produce a topical preparation in the form of a hydrogel eye mask from egg yolk which is useful for overcoming Computer Vision Syndrome(CVS).
Methods: This study formulated three formulas with the active ingredients of egg yolk extract 400µg, 600µg and 800µg using 8.75 g of sodium alginate base and 3.75 g of xanthan gum. Evaluation of the preparations included organoleptic tests, weight and size, pH, swellability, shrinkage, homogeneity, viscosity, spreadability, adhesion and stability tests.
Results: of the evaluation of the preparations hydrogel eye mask in the three formulas showed good physical characteristics and stability. The results of the evaluation that have been carried out show that the organoleptic test has no changes in color, odor and shape. Test the appropriate weight and size under the eye area. The pH test of the three formulas before storage was 7.3±0.15, 7.1±0.05, 7.1±0.17 and after storage 7.5±0.1, 7.4±0.1, 7.2±0.2. The expansion and shrinkage test showed an increase in weight every hour and a decrease in weight every 10 minutes. The homogeneity test showed the three formulas were homogeneous. The viscosity test is in a good range. The dispersion test of the three formulas before storage was 5.13±0.2, 5.07±0.15 and 5.18±0.28 cm and after storage was 5.05±0.13, 5.20±0.32, and 5.11±0.22 cm. The adhesion of each formula before storage was 4.23±0.51, 3.27±0.84, 3.28±0.62 seconds and after storage 3.24±0.38, 3.26±0.15, 2.96±0.77 seconds.
Conclusion: The three formulas produced have good pharmaceutical characteristics and stability so that they can be used to treat Computer Vision Syndrome (CVS).

Peer Review History:
Received: 5 September 2021; Revised: 8 October; Accepted: 25 October, Available online: 15 November 2021
Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Indones
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Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 5.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Mohammad Bayan, Faculty of Pharmacy, Philadelphia University, P.O. Box: 1 Philadelphia University 19392 Jordan, mbayan01@qub.ac
Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, sally.elzahaby@yahoo.com
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