bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of Bioethanol from Pineapple Peel (ananas comosus L. Mer) Waste with the Addition of Hydrochloric Acid and Citric Acid Catalysts
Authors: Khairani Nur , Mulyawan Rizka , Meriatna  , Muarif Agam , Bahri Syamsul , Kamar Iqbal 
Published: December 2024

Bioethanol is ethanol derived from biological sources. Bioethanol can be produced from plants that contain many starch and cellulose compounds using the help of yeast activity. One of them is pineapple peel which can add a variety of basic materials for bioethanol production which is economical and easy to obtain. This study aims to analyze the effect of acid hydrolysis on glucose content, analyze the effect of fermentation time and the effect of yeast weight on bioethanol characteristics. This research has been done before and only focused on one catalyst. What has never been done is comparing the two catalysts. The research was conducted using hydrolysis fermentation and distillation using hydrochloric acid and citric acid catalysts with yeast weight variation of 12, 15, and 17 grams, fermentation time variation of 2, 3, 4, and 5 days. In this research, glucose test, density analysis, yield analysis, and GC-MS were conducted. The results of this study showed that the best results in the treatment of hydrochloric acid catalyst at a yeast weight of 15 grams, and obtained glucose levels of 6.90% for hydrochloric acid and 5.10% for citric acid, density test obtained the highest results at a yeast weight of 15 grams 4 days 0.8288 gr / ml for hydrochloric acid catalyst and the lowest density obtained at a yeast weight of 17 grams 5 days 0, 8168 gr/ml, yield analysis obtained at the amount of 15 grams of yeast with a fermentation time of 14 days of 4.3536% in the treatment of hydrochloric acid catalyst and 3.8557% in the treatment of citric acid catalyst fermentation time of 3 days, GC-MS test showed that ethanol contained in the test sample.
Desafios para o partido comunista chinês e as possibilidades de cooperação Brasil- China
Authors: Maia Isis Paris , Pautasso Diego , Von Dentz Eduardo , Lamoso Lisandra Pereira 
Published: December 2024

Este ano, Brasil e China comemoram 50 anos de relações diplomáticas. Para refletir sobre essa parceria ,que tem se tornado mais complexa e estratégica, o presente dossiê entrevistou intelectuais brasileiros e chineses. São personalidades reconhecidas e influentes em suas instituições e áreas de atuação que nos deram a honra de compartilhar um pouco de suas impressões.
A Theoretical Exploration of Hyperconcepts: Hyperfunctions, Hyperrandomness, Hyperdecision-Making, and Beyond (Including a Survey of Hyperstructures)
Authors: Fujita Takaaki 
Published: December 2024

This paper delves into the concepts of Hyperfunctions and n -Superhyperfunctions, extending classical set functions into higher-order frameworks. By generalizing properties such as randomness, monotonicity, recursion, and symmetry, it explores their mathematical foundations and potential applications across various disciplines. Additionally, the paper investigates future directions, including Weak Hyperstructures, Weak Hypergraphs, Hypercontexts, Hypervariables, Powerset Convolutions, Hypermatrices, Hyperfields, Hyperlattices, Cognitive Hypermaps, Hyperdecision-making, and more. It evaluates the feasibility of extending these concepts into the domain of SuperHyperStructures. Although primarily theoretical, this study lays a robust foundation for future research, showcasing the versatility of Hyperstructures in addressing complex, multi-layered challenges.
Контраст-асоційоване гостре пошкодження нирок: клінічні рекомендації Української асоціації нефрологів і фахівців з трансплантації нирки
Authors: Kolesnyk M. , Kostylev M. , Stepanova N. , Shifris I. , Zatsarynny R. 
Published: December 2024

Йодовмісні контрастні речовини (ЙВКР) – одні з найпоширеніших лікарських засобів (ЛЗ), які застосовуються у медичній практиці з діагностичною чи інтервенційною метою. Гостре пошкодження нирок (ГПН), яке виникає після внутрішньосудинного введення ЙВКР є потенційно життєзагрожучим станом безпосередньо та асоціюється з підвищеним ризиком довгострокової смертності. В Україні існує нагальна необхідність інформування широкого лікарського загалу про суттєві зміни складових парадигми внутрішньосудинного застосування ЙВКР у клінічній практиці, у зв'язку з цим робоча група УАН і ФТН створила ці рекомендації щодо профілактики, діагностики та лікування контраст-асоційованого ГПН.
Immunohistochemical evaluation of the effect of neurotrophic factors on the bladder of rats with infravesical obstruction after administration of biologically active compositions
Authors: Globa V. , Bozhok G. , Legach E. , Samburg Y. , Godlevska O. , Vlasenko О. 
Published: December 2024

The present study aimed to investigate the immunohistochemical characteristics of the bladder (UB) of rats with infravesical obstruction (IVO) after intraperitoneal administration of biologically active compositions (BACs) (conditioned media (CM) of native and cryopreserved cultures of mantle gliocytes (MG) obtained from the spinal ganglia (SG).
Methods. IVO was reproduced by surgical ligation. BACs were intraperitoneally injected for 10 days. The relative area of expression of S100 protein and actin, as markers of bladder nerve and smooth muscle cells, was calculated. The experimental animals were divided into groups as follows: 1 - intact control (n=15); 2 - CM from the culture of native MG (n=7); 3 - CM from the culture of cryopreserved MG (n=6); 4 - animals with IVO without treatment (n=15).
Results. BACs obtained from the culture of native and cryopreserved MG were involved in the remodeling of the bladder structure, which changed during IVO. Visual assessment of the UB tissue specimens subjected to immunohistochemical labelling with antibodies to S100 protein and actin revealed an increase in the relative area of positive labelling in animals of groups 2 and 3 compared to group 4 (untreated). Statistical analysis demonstrated an increase in the relative area of expression of the studied markers of nervous and muscle structures by both indicators in animals of group 2 by 91.6% and 78.9% (p = 0.004; p = 0.002, respectively) compared to group 4 (without treatment). A somewhat different trend was observed when comparing the results of group 3. A statistically insignificant increase in the relative area of S100 protein expression in the UB tissues (p>0.05) and a significantly higher expression of actin by 78.8% (p=0.001) were found compared to the untreated group.
Conclusions. The positive effect of neurotrophic factors contained in the secretions of native/cryopreserved SG cell cultures on the expression of immunohistochemical markers of nerve and smooth muscle cells of the bladder in the course of IVO in rats has been found. It has been determined that cryopreservation affects the nature of the biological activity of the secretions of SG cell culture. At the same time, the administration of CM of cryopreserved culture has been proven to be effective in correcting the effects of IVO and similar to the effect of CM of native culture.
Em defesa da formação continuada de professores como atividade intelectual: argumentos a partir de Antonio Gramsci
Authors: Esquinsani Rosimar Serena , Fátima Lima do Prado Viviane 
Published: December 2024

O texto objetiva apresentar argumentos em defesa da formação continuada de professores como atividade intelectual, a partir de excertos do pensamento de Antonio Gramsci (1891 – 1937). Os argumentos ganham corpo considerando uma pesquisa descritiva, edificada em uma metodologia dialética, com procedimento analítico reconstrutivo e amparada por uma revisão bibliográfica. Como eixo condutor da narrativa, observou-se a leitura crítica de parte da obra de Gramsci, em razão do conceito de intelectual e do emparelhamento de tal conceito a formação continuada de professores, considerando tal ação como uma atividade intelectual. Em seu desenvolvimento, o texto discute o conceito de intelectual em Gramsci e as razões pelas quais ele se aplicaria a atividade laboral docente. Conclui identificando no professor, a figura de um intelectual orgânico, tal qual proposto por Antonio Gramsci, mas assevera que, diante de ações que colidem com a atividade laboral, incluindo a formação continuada, como uma atividade intelectual, é necessário reforçar argumentos e denunciar pautas que subtraem do professor tal atividade.
Yes-associated protein-based detection of acute type A aortic dissection and evaluation of therapeutic responses
Authors: Zhu Kai , Li Hao-Xi , Wu Dong-Dong , Qian Si-Chong , Wang Xiao-Long , Li Jian-Rong , Jiang Wen-Jian , Liu Hong , Li Hai-Yang , Zhang Hong-Jia 
Published: December 2024

BackgroundAcute aortic dissection is a lethal cardiovascular emergency; early diagnosis is critically necessary. Novel serum biomarkers can potentially help in early detection and estimation of postoperative outcomes. Yes-associated protein (YAP) is a critical effector of the Hippo pathway, our aim was to explore the association between YAP and the diagnosis and prognosis of AD.MethodsWe prospectively recruited 110 consecutive chest-pain patients [acute type A aortic dissection (ATAAD), n = 60; acute coronary syndrome (ACS), n = 50]. Blood samples were collected to determine levels of YAP and other serum biomarkers, and receiver operating characteristic curves (ROC) were constructed to assess the predictability in early diagnosis of AAD and postoperative major adverse events (MAEs).ResultsYAP concentration was substantially elevated among ATAAD patients [3.45 (3.18, 3.63) vs. 2.44 (2.23, 2.59), P &lt; 0.01]. Moreover, the white blood cell (WBC) count and plasma fibrin D-dimers were remarkably high among ATAAD patients [11.46 (9.57, 14.03) vs. 6.24 (5.10, 7.30), P &lt; 0.01; 2,097.00 (998.75, 3,652.00) vs. 97.00 (67.25, 137.00), P &lt; 0.01]. The serum YAP level held as a good predictive value in early diagnosis of ATAAD. The optimal cutoff value was 3.15 ng/ml, with an AUC of 0.94 (95% CI, 0.90–0.98, P &lt; 0.01), sensitivity of 80% and specificity of 98%. The combined model of YAP, WBC count and D-Dimer exhibited an enhanced predictive power, with an AUC of 0.99 (95% CI, 0.98–1.00, P &lt; 0.01). Serum YAP values at 12 h post-surgery provided the most accurate prediction of postoperative MAEs, with an optimal cutoff value of 3.60 ng/ml, an AUC of 0.89 (95% CI, 0.79–0.99, P &lt; 0.01), and sensitivity and specificity of 88% and 82%, respectively.ConclusionsThe serum YAP concentration is an early and sensitive serum bioindicator for distinguishing AAD from ACS. Moreover, the amount of postoperative circulating YAP is a robust indicator of postoperative MAEs.
The current state of wearable device use in Parkinson's disease: a survey of individuals with Parkinson's
Authors: Hirczy Siegfried , Zabetian Cyrus , Lin Yi-Han 
Published: December 2024

BackgroundInterest in wearable device use in Parkinson's disease (PD) has grown rapidly with many compelling studies supporting diagnostic and therapeutic uses. Concurrently, consumer devices have proliferated and their role in health and wellness has expanded. However, incorporation of consumer and medical wearable devices into medical care has in our experience been limited.ObjectiveWe sought to assess the current state of consumer and medical wearable device use among those with PD and to understand the factors impacting their rate of use.MethodsAn anonymous online survey of individuals with PD in the US was conducted from July 9th, 2023, to Jan 8th, 2024, with 298 completed responses collected.ResultsGreater than 90% of respondents were interested in new technologies with 67% having had experiences with consumer wearable devices. Only 24% were using consumer devices for disease management and many functions were not fully utilized. Medical wearable device use was very limited with only 8% having used a device. Users of both consumer and medical wearables generally reported low barriers to use despite continued strong perceptions on the importance of cost, impact on care, comfort, and other factors.ConclusionThis study demonstrates that for the clinical management of PD there is limited use of wearable devices even among individuals who are motivated and experienced with consumer wearable device use. Additionally, it is suggested that substantial barriers to medical wearable use are likely originating from the provider and/or systemic level.
LH level on trigger day, number of follicles ≥16 mm but <18 mm, and number of retrieved oocytes are independent risk factors for polyspermy in gonadotropin-releasing hormone antagonist protocol
Authors: Wu Qiongyu , He Lina 
Published: December 2024

IntroductionThe polyspermy rate is a quality control indicator in the embryology laboratory, and factors affecting polyspermy are of great interest. The gonadotropin-releasing hormone (GnRH) antagonist protocol is currently the mainstream protocol in most reproductive centers. This study explored the factors influencing polyspermy in in vitro fertilization (IVF) using the GnRH antagonist protocol and considered corresponding improvement measures.MethodsThis retrospective case-control study analyzed 354 patients who underwent conventional IVF with a GnRH antagonist protocol at Zigong Maternal and Child Health Hospital from November 2019 to September 2023. Patients were divided into two groups based on the occurrence of polyspermy, and baseline characteristics and clinical data were compared between the groups. Variables with P&lt;0.05 in univariate logistic regression were included in the multivariate logistic regression model. Cutoff values for variables with P&lt;0.05 were calculated.ResultsMultivariate logistic regression corrected for confounding factors identified that luteinizing hormone (LH) level on trigger day, the number of follicles ≥16 mm but &lt;18 mm, and the number of retrieved oocytes were significantly associated with polyspermy (OR=1.305, P=0.005; OR=1.235, P=0.002; OR=1.101, P&lt;0.001, respectively). The cutoff values were 1.95 IU/L, 4.5 follicles, and 16.5 oocytes, respectively.ConclusionIn the GnRH antagonist cycle, LH level on trigger day, the number of follicles ≥16 mm but &lt;18 mm, and the number of retrieved oocytes are independent risk factors for polyspermy. When LH level on trigger day exceeds 1.95 IU/L, the number of follicles ≥16 mm but &lt;18 mm exceeds 4, and the number of oocytes retrieved exceeds 16, the risk of polyspermy increases significantly.
An intelligent adaptive neuro-fuzzy based control for multiport DC-AC converter with differential power processing converter for hybrid renewable power generation systems
Authors: Shanmugam S. , Sharmila A. 
Published: December 2024

The increasing demand for renewable energy sources necessitates the development of sophisticated control systems that can seamlessly integrate and manage multiple power sources. This research introduces an advanced intelligent adaptive neuro fuzzy-based control (IANFC) for multiport DC-AC converters with differential power processing (DPP) converters, tailored for customized hybrid renewable power generation systems (HRPGS). The system aims to optimize HRPGS performance and efficiency through neuro-fuzzy control techniques. When integrating different DC power sources, such solar panels and wind turbines, into AC loads or the grid, multiport DC-AC converters are essential. These converters reduce the amount of power conversion steps, which improves the system’s overall efficiency and scalability. Complementary DPP converters process only the differential power, thereby significantly reducing total power consumption and conversion losses. The IANFC framework combines fuzzy logic reasoning, based on rules, with neural network adaptive learning capabilities. This hybrid control method effectively manages the nonlinear and dynamic behavior of HRPGS, ensuring reliable performance under varying load demands and environmental conditions. The controller dynamically adjusts the converter’s operating point to ensure optimal power flow and system stability. Simulation findings using MATLAB/Simulink verify the efficacy of the suggested IANFC system. Under various operational situations, key performance measures like response time, stability, and system efficiency are examined. As evidenced by the data, system performance has significantly improved as compared to traditional control techniques. The proposed system demonstrates an efficiency of 99.45% and achieves stability in just 0.02 s. Compared to conventional algorithms, this approach shows superior performance across multiple metrics.
Deciphering community-level knowledge of obstetric fistula and determinants: perspectives elucidated by ordinal logistic regression
Authors: Limenih Miteku Andualem , Melesse Alemakef Wagnew , Baye Chernet , Shewabere Beletew , Mekonnen Eskedar Getie , Hassen Hamid Yimam , Berhe Aster , Shiferaw Alemu Destaye , Chanie Wagaye Fentahun 
Published: December 2024

BackgroundObstetric fistula is a significant cause of maternal morbidity in resource-limited settings, where women often suffer due to a lack of prompt access to skilled obstetric services. It is imperative to comprehend and identify the factors that shape community knowledge about obstetric fistula to enhance prevention strategies, enable early detection, and provide support and treatment to affected women. However, there is a substantial gap in the available evidence concerning the level of community knowledge regarding obstetric fistula and its influencing factors within the Ethiopian context.ObjectiveThis study aimed to investigate the level of knowledge regarding obstetric fistula and identify influencing factors within the communities in Gondar, Ethiopia.MethodsA community-based cross-sectional study was conducted among 663 households. Households were selected using a systematic random sampling technique. Descriptive statistics and exact binomial confidence intervals (CIs) were reported. Group comparisons were performed using the Mann–Whitney U-test or the Kruskal–Wallis test. Parameters with p-value ≤ 0.2 in the univariable ordinal regression were selected for the multivariable ordinal regression model. The proportion odds assumption was checked using the parallel lines test. A multivariable proportional ordinal regression analysis was conducted. p-values &lt;5% were considered statistically significant. Data were analyzed using R version 4.3.1.ResultOf the 663 households, 265 (39.9%; 95% CI: 36.2–43.8), 375 (56.6%; 95% CI: 52.7–60.4), and 23 (3.5%; 95% CI: 2.2–5.2) had low-level, medium-level, and high-level knowledge about obstetric fistula, respectively. Self-employment [adjusted odds ratio (AOR): 0.3; 95% CI: 0.2–0.5], unemployment (AOR: 0.4; 95% CI: 0.2–0.8), income $50–$200 USD (AOR: 5.2; 95% CI: 2–16.1), income &gt; $200 USD (AOR: 7.0; 95% CI: 2.6–22.9), distance from a health facility (AOR: 1.7; 95% CI: 1.1–2.7), non-participation in women’s conferences (AOR: 0.7; 95% CI: 0.5–0.9), and having heard of obstetric fistula (AOR: 4.4; 95% CI: 2.8–7.1) showed statistically significant association with the likelihood of having a high level of knowledge regarding obstetric fistula compared to medium or low levels.ConclusionThe study reveals an alarmingly low level of knowledge about obstetric fistula. Higher income and prior awareness were associated with increased knowledge about obstetric fistula, while self-employment, unemployment, and non-participation in women's conferences were liked to decreased knowledge. Enhancing community knowledge requires a holistic strategy involving cooperation from all stakeholders and tackling broader socio-economic disparities.
Tacrolimus to belatacept conversion in proteinuric kidney transplant recipients
Authors: Efe Orhan , Al Jurdi Ayman , Eiting Morgan Mabey , Marks Christine Rogers , Cote Mariesa Ann , Wojciechowski David , Safa Kassem , Gilligan Hannah , Azzi Jamil , Goyal Nitender , Raynaud Marc , Loupy Alexandre , Weins Astrid , Riella Leonardo V. 
Published: December 2024

BackgroundProteinuria is associated with worse allograft outcomes in kidney transplant recipients (KTRs) and treatment strategies are limited. We examined the outcomes of calcineurin inhibitor (CNI) to belatacept conversion in proteinuric KTRs.MethodsIn a pilot phase II single-arm multicenter prospective trial, we recruited adult KTRs &gt;6 months post-kidney transplantation with an estimated glomerular filtration rate (eGFR) ≥30 ml/min/1.73m2 and proteinuria &gt;1 g/day. Patients were converted from CNI to belatacept. The primary outcome was a 25% reduction in proteinuria at 12 months.ResultsA total of 15 KTRs were recruited who had pre-conversion median (interquartile range) proteinuria of 1.8 (IQR 1.4 – 3.5) g/g and estimated glomerular filtration rate (eGFR) of 48 (IQR 32 – 52.5) ml/min/1.73m2. At 12 months post-conversion, median proteinuria was 1.4 (IQR 0.4 – 2.2) g/g (P = 0.068) and eGFR was maintained at 43 (34 – 54.5) ml/min/1.73m2. The primary outcome of at least a 25% reduction in proteinuria occurred in 53% (8/15) at 12 months. Abbreviated IBOX scores predicting 7-year graft survival were also stable at 1-year post-conversion compared to baseline. At extended follow-up at 5 years, both proteinuria and eGFR remained stable at 0.69 (0.24 – 2.15) g/g and 39 (31 – 57) ml/min/1.73m2, respectively.ConclusionsCNI to belatacept conversion was associated with preserved allograft function in KTRs with significant proteinuria. These findings need to be confirmed in a larger randomized clinical trial.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT0232740.
The role of APOE gene polymorphisms in lung adenocarcinoma susceptibility and lipid profile
Authors: Bi Huanhuan , Ren Dunqiang , Wang Ye , Wang Hongmei , Zhang Chunling 
Published: December 2024

BackgroundAPOE gene polym orphisms have been linked to Alzheimer’s disease and coronary heart diseases. However, their relationship with lung adenocarcinoma (LUAD) remains uncertain.MethodsThis study analyzed a cohort of 600 individuals comprising 200 LUAD patients in the lung cancer group and 400 healthy individuals as controls. APOE gene variants were identified through Sanger sequencing. Statistical analyses were conducted to assess intergroup differences, and comparisons of lipid profiles were performed across individuals carrying different APOE alleles.ResultsThe APOE ϵ2 allele had been significantly more frequently occurring in the LUAD group than in the control group (15.5% vs. 7%, P &lt;0.001). APOE ϵ2/ϵ2 and ϵ2/ϵ3 genotypes increased susceptibility to LUAD by 3.78-fold and 3.22-fold. The APOE ϵ2/ϵ3 genotype increased the risk of early-stage LUAD by 2.36-fold and advanced-stage LUAD by 4.05-fold. Individuals with the APOE ϵ2/ϵ2 genotype had a 3.22-fold higher susceptibility to moderately differentiated and a 6.8-fold higher susceptibility to poorly differentiated LUAD. Patients with the ϵ2 allele in LUAD exhibited disrupted lipid metabolism, characterized by reduced HDL, TC, and FFA levels, along with increased ApoB, particularly in advanced and poorly differentiated cancer stages.ConclusionIndividuals carrying the ϵ2 allele have an increased susceptibility to developing LUAD, accompanied by disrupted lipid metabolism. Additionally, the APOE ϵ2/ϵ2 and ϵ2/ϵ3 genotypes are associated with an increased risk of developing advanced and poorly differentiated LUAD.