bluuebunny/crossref_metadata_2025_split huggingface dataset:
LungBEAM: A prospective multicenter study to monitor stage IV NSCLC patients with EGFR mutations using BEAMing technology
Authors: Garrido Pilar , Paz‐Ares Luis , Majem Margarita , Morán Teresa , Trigo José Manuel , Bosch‐Barrera Joaquim , Garcίa‐Campelo Rosario , González‐Larriba José Luis , Sánchez‐Torres José Miguel , Isla Dolores , Viñolas Núria , Camps Carlos , Insa Amelia , Juan Óscar , Massuti Bartomeu , Paredes Alfredo , Artal Ángel , López‐Brea Marta , Palacios José , Felip Enriqueta 
Published: July 2021

AbstractObjectivesThe aim of LungBEAM was to determine the value of a novel epidermal growth factor receptor (EGFR) mutation test in blood based on BEAMing technology to predict disease progression in advanced non‐small cell lung cancer (NSCLC) patients treated with first‐ or second‐generation EGFR‐tyrosine kinase inhibitors (EGFR‐TKIs). Another goal was to monitor the dynamics of EGFR mutations, as well as to track EGFR exon 20 p.T790M (p.T790M) resistance during treatment, as critical indicators of therapeutic efficacy and patient survival.MethodsStage IV NSCLC patients with locally confirmed EGFR‐TKI sensitizing mutations (ex19del and/or L858R) in biopsy tissue who were candidates to receive first‐ or second‐generation EGFR‐TKI as first‐line therapy were included. Plasma samples were obtained at baseline and every 4 weeks during treatment until a progression‐free survival (PFS) event or until study completion (72‐week follow‐up). The mutant allele fraction (MAF) was determined for each identified mutation using BEAMing.ResultsA total of 68 of the 110 (61.8%) patients experienced a PFS event. Twenty‐six patients (23.6%) presented with an emergent p.T790M mutation in plasma at some point during follow‐up, preceding radiologic progression with a median of 76 (interquartile ratio: 54–111) days. Disease progression correlated with the appearance of p.T790M in plasma with a hazard ratio (HR) of 1.94 (95% confidence interval [CI], 1.48–2.54; p < 0.001). The HR for progression in patients showing increasing plasma sensitizing mutation levels (positive MAF slope) versus patients showing either decreasing or unchanged plasma mutation levels (negative or null MAF slopes) was 3.85 (95% CI, 2.01–7.36; p < 0.001).ConclusionDetection and quantification of EGFR mutations in circulating tumor DNA using the highly sensitive BEAMing method should greatly assist in optimizing treatment decisions for advanced NSCLC patients.
CNTs‐CaP/chitosan‐coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway
Authors: Liu Tingjiao , Li Qianqian , Yang Shanshan , Zhao Tingting , Lin Jinghan , Ju Ting , Wen Zhaohui 
Published: July 2021

Increasing attention has been paid on the application of biodegradable materials such as magnesium and its alloys in neuron repair. AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated in this study. To evaluate the bioactivity of these AZ91D‐based composites, the extracts were prepared by immersing samples in modified simulated body fluid (m‐SBF) for 0, 2, 8, 16, 24, 34, 44, 60, or 90 days. Immunofluorescence staining for neuronal class III β‐tubulin (TUJ1) revealed that both CNTs‐CaP/CS‐AZ91D and CaP/CS‐AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p‐FAK) and growth associated protein‐43 (GAP‐43). Besides, the extracts increased the expression and the release of neurotrophic factors including nerve growth factor (NGF) and brain‐derived neurotrophic factor (BDNF). ERK signalling was activated in DRG neurons after treating with either CNTs‐CaP/CS‐AZ91D or CaP/CS‐AZ91D extracts, and its inhibition with U0126 counteracted the beneficial effects of these extracts on DRG neuron. Overall, the extracts from these AZ91D‐based composites might promote DRG neuron growth via activating ERK signalling pathway. Notably, CNTs‐CaP/CS‐AZ91D extracts showed a better promoting effect on neuron growth than CaP/CS‐AZ91D. Assessment of ion elements showed that the addition of CNTs coating enhanced magnesium corrosion resistance and reduced the deposition of calcium and phosphorus on the surface of CaP/CS‐AZ91D alloy. These findings demonstrate that CNTs‐CaP/CS‐AZ91D likely provide a more suitable environment for neuron growth, which suggests a potential implantable biomaterial for the treatment of nerve injury.SignificanceAZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated and their immersion extracts were prepared using modified simulated body fluid in this study. Both extracts from CNTs‐CaP/CS and CaP/CS‐coated AZ91D magnesium alloy promotes rat dorsal root ganglia (DRG) neuron growth via activating ERK signalling pathway. Notably, the addition of CNTs improves the performance of CaP/CS‐AZ91D. For the first time, our research demonstrates that CNTs‐CaP/CS‐AZ91D likely provide a suitable environment for neuron growth, suggesting these AZ91D‐based composites as potential implantable biomaterials for the treatment of nerve injury.
Scoliosis with peculiar radiological features in a patient with McCune‐Albright syndrome
Authors: Michev Alexandre , Lungarotti Luca , Prevedoni Gorone Maria Sole , Apicella Antonia , Di Vincenzo Giulia , Marseglia Gian Luigi , Brambilla Ilaria 
Published: July 2021

AbstractPatients with McCune‐Albright Syndrome (MAS) should always attend regular follow‐up. Beside the endocrinological aspects, the screening must take into account osteoarticular complications such as scoliosis, even in patients without fibrous dysplasia.
Premortem diagnosis of pathologically confirmed sporadic Creutzfeldt‐Jakob disease
Authors: Ziukelis Elina T , Sharma Vasu Keshav , Gome James J 
Published: July 2021

AbstractSporadic Creutzfeldt‐Jakob disease should be considered in any case of rapid neuropsychiatric decline. While neuropathological examination of a brain biopsy specimen remains the only definitive diagnostic method and real‐time quaking‐induced conversion tests have simplified premortem diagnosis, careful evaluation of magnetic resonance imaging can provide readily accessible clues.
Urine retention as presenting manifestation of tuberculous meningitis complicated by lacunar infarction and transverse myelitis: Case report and literature review
Authors: Salih Abdulhadi Ahmed , Abdelmahmuod Elabbass A. , Al‐Rubaiei Jawaher , Ali Elrazi , Mahfouz Ahmed Emad , Farooqi Amer 
Published: July 2021

AbstractEarly diagnosis and management of tuberculous meningitis will prevent lethal and fatal neurological complications such as acute infarction and permanent disability.
Clinical outcomes of post‐renal transplant patients with COVID‐19 infection in the ICU: A single‐center case series
Authors: Shaikh Nissar , Khatib Mohamad Y. , Alwraidat Mohammad A. , Ananthegowda Dore C. , Othman Muftah , Aroos Asra , Jujjavarapu Sagar B. , Banerjee Saptarshi , Nasir Zishan , Mohamed Ahmed S. , Elshafei Moustafa S. , Almaslamani Muna A. , Nashwan Abdulqadir J. 
Published: July 2021

AbstractMost of the post‐renal transplant patients are taking immunosuppressive medications, including calcineurin inhibitors, anti‐proliferative agents, and steroids. This case series highlights the clinical characteristics and outcomes of eight post‐renal transplant patients with severe COVID‐19 infection admitted to the intensive care unit.
Targeted treatment in viral‐associated inflammatory cardiomyopathy
Authors: Amin Ahmad , Taghavi Sepideh , Chenaghlou Maryam , Zare Elahe , Kamali Monireh , Naderi Nasim 
Published: July 2021

AbstractDetection of viruses like HHV‐6 in endomyocardial biopsy or serum serology of patients with myocarditis or heart failure features unresponsive to conventional heart failure therapies could be a potential targeted treatment especially in refractory cases.
Myocardial infarction following repair of a ruptured heart
Authors: Vakili Hossein , Taherpour Zhiva 
Published: July 2021

AbstractPenetrating chest trauma can lead to the cardiac rupture and coronary artery damage, which causes a high mortality rate (1). Most of the patients with penetrating cardiac trauma die at the scene of the accident (1). Coronary artery (CA) injuries are rare but highly lethal (2). Also, CA injury may occur during repair of a ruptured heart as in our reported case.
Use of alternative cerebrospinal fluid‐based biomarkers to help diagnose Xpert‐negative tuberculous meningitis: A case report
Authors: Poudel Deechit , Poudel Diptee , Poudel Dhiraj 
Published: July 2021

AbstractThe widely used Xpert MTB/RIF assay, limited by its suboptimal sensitivity, does not perform well as a rule‐out test for tuberculous meningitis. Alternative CSF‐based biomarkers can help determine the microbial etiology of clinical meningitis when standard diagnostic modalities fail.
Oral manifestations and dental care management of a young patient with lymphangioma of the tongue: A case report
Authors: Chouchene Farah , Masmoudi Fatma , Baaziz Ahlem , Maatouk Fethi , Ghedira Hichem 
Published: July 2021

AbstractChildren with lymphangioma of the tongue may require a close collaboration between physician and dentist to establish preventive, conservative approaches, and eradicate any sources of dental infections before undertaking immunosuppressive therapy.
Rebleeding in aneurysm after rectal enema: Re‐emphasis on careful subarachnoid hemorrhage management
Authors: Shrestha Suraj , Raut Akash , Homagain Sushan , Sedain Gopal , Ramtel Rupesh 
Published: July 2021

AbstractRebleeding in an aneurysmal subarachnoid hemorrhage (SAH) is catastrophic with high mortality and grave outcome. Meticulous management of SAH patients and the prevention of activities that might increase the chances of rebleeding are life‐saving.
Sequential development of ANCA‐associated vasculitis and anti‐GBM disease: A report of two cases
Authors: Le Moine Camille , Jourde‐Chiche Noémie , Kemlin Delphine , Terrier Benjamin , Vandergheynst Frédéric 
Published: July 2021

AbstractIn case of AAV with kidney involvement, physicians should explore anti‐GBM antibodies and be aware of the possible sequential development of AAV, especially with MPO‐ANCA, and anti‐GBM glomerulonephritis. This sequential disease history is associated with a poor renal outcome, highlighting the need for urgent diagnosis and management.
The combined effect of hypomagnesemia and hypokalemia inducing nephrogenic diabetes insipidus in a patient with type 1 diabetes mellitus
Authors: Sangey Esmail , Chudasama Kishan , Mwinyi Ahmad 
Published: July 2021

AbstractNephrogenic diabetes insipidus (NDI) is rarely considered against more common differentials such as diabetes mellitus in patients presenting with polydipsia and polyuria. Hypokalemia and hypercalcemia are known to induce NDI, but not much is known about hypomagnesemia. Hypokalemia refractory to therapy should prompt consideration of hypomagnesemia.
Blocky Sb/C Anodes with Enhanced Diffusion Kinetics for High‐Rate and Ultra‐Long Cyclability Sodium Dual‐Ion Batteries
Authors: Li Hong‐Ji , Li Jing‐Jing , Chen Zhe , Wang Zhen‐Zhen , Qu Jin , Chen Yi‐Qian , Zhu Li‐Jun , Jiang Fei 
Published: July 2021

AbstractSodium ion‐based dual ion batteries (SDIBs) have attracted increasing attentions for their high operative voltages and low cost, but their poor long‐term cycling stability and rate capability largely hinder their practical applications. Here, an optimized anode‐antimony/carbon/graphene (Sb/C/G) composite for SDIBs is designed. Sb nanoparticles (NPs) not only can enhance the specific capacity but also facilitate the Na+ diffusion kinetics. The continuous conductive carbon matrix can promote the electron transfer process and accommodate volume changes of Sb NPs during sodiation/desodiation. Therefore, superior electrochemical performance, for example, a high discharge capacity of 376 mA h g−1 with a higher ICE (69.1 %) at current density of 500 mA g−1, an excellent cycling stability (73 mA h g−1 is retained even after 1400 cycles at current density of 1000 mA g−1), and high stable CE of 99.0 %. Our study offers a suitable design for Na+‐based batteries anode structure and accelerates their practical applications.
New Ideas for Understanding the Structure and Magnetism in AgF2: Prediction of Ferroelasticity
Authors: Sánchez‐Movellán Inés , Moreno‐Ceballos Jorge , García‐Fernández Pablo , Aramburu Jose Antonio , Moreno Miguel 
Published: July 2021

AbstractIn the search for new high‐temperature superconductors, it has been proposed that there are strong similarities between the fluoroargentate AgF2 and the cuprate La2CuO4. We explored the origin of the possible layered structure of AgF2 by studying its parent high‐symmetry phase and comparing these results with those of a seemingly analogous cuprate, CuF2. Our findings first stress the large differences between CuF2 and AgF2. Indeed, the parent structure of AgF2 is found to be cubic, naturally devoid of any layering, even though Ag2+ ions occupy trigonal sites that, nevertheless, allow the existence of a Jahn‐Teller effect. The observed Pbca orthorhombic phase is found when the system is cooperatively distorted by a local E⊗e trigonal Jahn‐Teller effect around the silver sites that creates both geometrical and magnetic layering. While the distortion implies that two Ag2+−F− bonds increase their distance by 15 % and become softer, our simulations indicate that covalent bonding and interlayer electron hopping is strong, unlike the situation in cuprate superconductors, and that, in fact, exfoliation of individual planes might be a harder task than previously suggested. As a salient feature, these results prove that the actual magnetic structure in AgF2 is a direct consequence of vibronic contributions involved in the Jahn‐Teller effect. Finally, our findings show that, due to the multiple minima intrinsic to the Jahn‐Teller energy surface, the system is ferroelastic, a property that is strongly coupled to magnetism in this argentate.
Current Advances on Zn Anodes for Aqueous Zinc‐Ion Batteries
Authors: Li Xin , Zeng Jiaming , Yao Hong , Yuan Du , Zhang Liping 
Published: July 2021

AbstractAs the representative in rechargeable multivalence ion batteries, aqueous zinc ion battery (ZIB) is a promising safe and green solution in the post‐lithium ion era. Though ZIB is being intensively investigated due to its unique merits, the development of ZIB is facing the fundamental obstacles during Zn stripping/plating, namely, zinc dendrite formation, hydrogen evolution, and solid‐electrolyte interface (SEI) formation, which severely affect the cycling stability of ZIB. In this minireview, we aim to provide current aspects of novel approaches to deal with the above critical issues. The approaches are discussed from the perspectives of regulation of electrolyte, construction of Zn anode, and design of surface coating or SEI layer, where their effects on Zn deposition and surface evolution are focused. Last, the challenges and outlooks on the current approaches towards highly reversible Zn anode are presented for the development of ZIB.
A scalable high‐speed hybrid 1‐bit full adder design using XOR‐XNOR module
Authors: Hasan Mehedi , Islam Sharnali , Hossain Mainul , Zaman Hasan U. 
Published: July 2021

AbstractHigh‐speed XOR‐XNOR‐based hybrid full adder (FA) using a combination of three logic techniques (transmission gate [TG], conventional CMOS [CCMOS], pass transistor [PT]) is presented in this work. Performance analysis and validation of the FA design presented in this work have been realized with reference to 10 state‐of‐the‐art FAs. The scalability of the design has been tested by extending FA up to 32‐bits in ripple carry adder (RCA) style. It has been observed that only four existing FAs and the proposed FA could be scaled up to 32‐bits without including voltage restoration buffers in the internal stages. The proposed XOR‐XNOR‐based FA showed excellent performance metrics, both as a 1‐bit adder cell as well as in wide word length adder form. Hence, the proposed XOR‐XNOR‐based hybrid FA can serve as a better alternative to the existing FAs in digital arithmetic blocks of modern microprocessors.
The Human Melanoma Proteome Atlas—Complementing the melanoma transcriptome
Authors: Betancourt Lazaro Hiram , Gil Jeovanis , Sanchez Aniel , Doma Viktória , Kuras Magdalena , Murillo Jimmy Rodriguez , Velasquez Erika , Çakır Uğur , Kim Yonghyo , Sugihara Yutaka , Parada Indira Pla , Szeitz Beáta , Appelqvist Roger , Wieslander Elisabet , Welinder Charlotte , de Almeida Natália Pinto , Woldmar Nicole , Marko‐Varga Matilda , Eriksson Jonatan , Pawłowski Krzysztof , Baldetorp Bo , Ingvar Christian , Olsson Håkan , Lundgren Lotta , Lindberg Henrik , Oskolas Henriett , Lee Boram , Berge Ethan , Sjögren Marie , Eriksson Carina , Kim Dasol , Kwon Ho Jeong , Knudsen Beatrice , Rezeli Melinda , Malm Johan , Hong Runyu , Horvath Peter , Szász A. Marcell , Tímár József , Kárpáti Sarolta , Horvatovich Peter , Miliotis Tasso , Nishimura Toshihide , Kato Harubumi , Steinfelder Erik , Oppermann Madalina , Miller Ken , Florindi Francesco , Zhou Quimin , Domont Gilberto B. , Pizzatti Luciana , Nogueira Fábio C. S. , Szadai Leticia , Németh István Balázs , Ekedahl Henrik , Fenyö David , Marko‐Varga György 
Published: July 2021

AbstractThe MM500 meta‐study aims to establish a knowledge basis of the tumor proteome to serve as a complement to genome and transcriptome studies. Somatic mutations and their effect on the transcriptome have been extensively characterized in melanoma. However, the effects of these genetic changes on the proteomic landscape and the impact on cellular processes in melanoma remain poorly understood. In this study, the quantitative mass‐spectrometry‐based proteomic analysis is interfaced with pathological tumor characterization, and associated with clinical data. The melanoma proteome landscape, obtained by the analysis of 505 well‐annotated melanoma tumor samples, is defined based on almost 16 000 proteins, including mutated proteoforms of driver genes. More than 50 million MS/MS spectra were analyzed, resulting in approximately 13,6 million peptide spectrum matches (PSMs). Altogether 13 176 protein‐coding genes, represented by 366 172 peptides, in addition to 52 000 phosphorylation sites, and 4 400 acetylation sites were successfully annotated. This data covers 65% and 74% of the predicted and identified human proteome, respectively. A high degree of correlation (Pearson, up to 0.54) with the melanoma transcriptome of the TCGA repository, with an overlap of 12 751 gene products, was found.Mapping of the expressed proteins with quantitation, spatiotemporal localization, mutations, splice isoforms, and PTM variants was proven not to be predicted by genome sequencing alone. The melanoma tumor molecular map was complemented by analysis of blood protein expression, including data on proteins regulated after immunotherapy. By adding these key proteomic pillars, the MM500 study expands the knowledge on melanoma disease.
Energy‐efficient remote mobile device management in infrastructure‐less environment for emergency assessment
Authors: Pandey Vipin Kumar , De Suddhasil 
Published: July 2021

SummaryPersonal mobile devices, or PMDs, have the main objective of supporting connectivity in infrastructured network. However, they are rarely researched to support connectivity in infrastructure‐less network environment, particularly in case of no network or when existing network is damaged. This research direction has significant benefit towards emergency management, where PMDs in affected areas can be configured to establish inexpensive infrastructure‐less network for victims' information gathering. Existing PMD configurations techniques either lack flexibility and hinder device reachability or are slow and consume significant energy. These factors have motivated towards the two‐fold contribution proposed in this paper—(1) a novel over‐the‐air mobile device management approach of PMDs to establish multi‐hop infrastructure‐less network and (2) additional over‐the‐air sensing configuration of PMDs to record and transmit incapacitated victims' surrounding conditions using proposed network. These contributions allow multiple PMDs to establish network with minimal time and energy overheads, leading to efficient emergency management. Simulation and testbed results validate proposed approaches.
An unusual case of paediatric plasmablastic lymphoma presenting with malignant effusion and the challenges in its diagnosis
Authors: Modi Nisha , Khurana Ujjawal , Mukhopadhyay Sramana , Joshi Deepti , Soni Deepti , Chaudhary Narendra , Malik Shikha , Shet Tanuja 
Published: July 2021

AbstractPlasmablastic lymphoma (PBL) is an aggressive non‐Hodgkin lymphoma occurring commonly in the oral mucosa and jaw of human immunodeficiency virus (HIV) positive adult males. PBL is not a common occurrence in children and a presentation with malignant effusion is rarely reported. Herein, we share our experience in the challenges confronted in the diagnosis of PBL in a 6‐year‐old, HIV positive boy presenting with malignant pleural and peritoneal effusions along with gum hypertrophy, lymphadenopathy and paranasal sinus mass. Amenability of pleural effusion to exfoliative cytology led to an initial cytological examination demonstrating large atypical lymphoid cells with plasmacytoid morphology and a plasmablastic variant of Burkitt lymphoma was initially considered. However immunophenotyping by flowcytometry (FCM) and a cell block immunohistochemical evaluation of the serous effusion suggested a plasma cell immunophenotype and a diagnosis of PBL was favored. A subsequent biopsy from the paranasal sinus mass confirmed the diagnosis of PBL but showed tumour cell angiocentricity on morphology and CD45 expression on immunohistochemistry (IHC), both unusual features in PBL. A CD20 negative/MUM‐1 positive immunoprofile and presence of a solid tumour mass in a typical location in addition to malignant effusion substantiated the diagnosis of PBL. The patient was offered HAART (highly active antiretroviral therapy) and chemotherapy and is on follow‐up. Paediatric PBL with malignant effusion is rarely reported and this case stresses the importance of use of a multimodality diagnostic approach for an accurate diagnosis.