bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ảnh hưởng của mức độ liên kết kháng cắt đến ứng xử uốn của dầm liên hợp thép – bê tông sử dụng liên kết kháng cắt dạng Perfobond: Phương pháp thực nghiệm
Authors: Nhân Lê Văn Phước , Vinh Bùi Đức , Duy Hồ Đức , Sơn Lê Thái , Tín Lưu Trần Hữu 
Published: April 2021

Hai mẫu dầm liên hợp kích thước lớn sử dụng liên kết Perfobond được thí nghiệm để khảo sát ứng xử uốn của dầm. Dầm thép có tiết diện T ngược và liên kết kháng cắt dạng Perfobond được gắn với nhau dọc theo chiều dài dầm liên hợp thép – bê tông. Phần thép và Perfobond được làm từ thép SS400, phần bê tông được chế tạo bằng bê tông C60/75. Sự khác nhau giữa hai dầm liên hợp thép – bê tông là số lỗ liên kết trong liên kết kháng cắt dạng Perfobond. Một dầm được bố trí 10 lỗ liên kết và dầm kia được bố trí 22 lỗ liên kết trong mỗi dầm. Mục tiêu của nghiên cứu nhằm đánh giá ảnh hưởng của mức độ liên kết đến ứng xử uốn của dầm liên hợp thép – bê tông sử dụng liên kết kháng cắt dạng Perfobond, như: khả năng chịu tải, chuyển vị, biến dạng tương đối giữa dầm thép và bản bê tông, các dạng phá hoại của dầm liên hợp. Kết quả thực nghiệm cho thấy hình thái liên kết ảnh hưởng đáng kể đến ứng xử uốn của dầm liên hợp thép – bê tông.
Từ khóa:
dầm liên hợp; liên kết kháng cắt; liên kết kháng cắt Perfobond; mức độ liên kết; biến dạng trượt tương đối; ứng xử uốn.
Nghiên cứu thiết kế bộ tời cứu hộ cá nhân
Authors: Giang Dương Trường , Tịnh Nguyễn Văn , Đăng Nguyễn Thiệu Trần 
Published: April 2021

Khi xảy ra sự cố trong các tòa nhà cao tầng, như cháy nổ bên trong toà nhà, cháy có thể chia cắt các tầng, dẫn đến thang máy, thang thoát hiểm bên trong không sử dụng được. Ở các thành phố lớn, đặc biệt là ở Việt Nam một số khu vực điều kiện kỹ thuật không đảm bảo cho lực lượng chữa cháy với phương tiện kỹ thuật chuyên nghiệp như xe thang không thể tiếp cận được. Việc phát triển thiết bị cứu hộ cá nhân để mỗi hộ gia đình sinh sống trong các tòa nhà cao tầng có thể tự trang bị và tự thoát hiểm là cần thiết. Trên cơ sở các nghiên cứu trước đó, bài báo đề xuất cấu tạo và nguyên lý làm việc của một bộ tời cứu hộ cá nhân, tính toán thiết kế và khảo sát các thông số động học chính trong quá trình làm việc. So với các thiết bị cứu hộ cá nhân khác về nguyên lý và cấu tạo, bộ tời đảm bảo kết cấu gọn và nhẹ, có cả hai chức năng nâng và hạ. Mặt khác nếu so sánh về công dụng thì bộ tời có thể được sử dụng như một thiết bị cứu hộ cá nhân đối với một người khỏe mạnh bình thường và nó cũng là một bộ phận của bộ tời đồng bộ khi kết hợp với giỏ thang và thang tháo lắp nhanh. Những kết quả khảo sát động lực học quá trình hạ trong bài báo đã đánh giá về độ an toàn và sự phù hợp của các thông số động học đối với người được cứu hộ khi sử dụng bộ tời thiết kế.
Từ khóa:
cứu hộ; bộ tời; giỏ nâng; phanh an toàn; động lực học.
ЗАКІНЧЕННЯ ДРУГОЇ СВІТОВОЇ ВІЙНИ ТА ПОЛОНЕННЯ ЯПОНСЬКОЇ АРМІЇ РАДЯНСЬКИМИ ВІЙСЬКАМИ
Authors: Карпов В.В. 
Published: April 2021

Закінчення Другої світової війни і полон японської армії радянськими військами для подальшого їх трудового використання на території СРСР засвідчили виникнення нового глобального процесу, який надалі отримав назву «холодної війни». Радянський Союз продемонстрував гнучку реак- цію на перспективу військового протистояння з США в умовах ядерної загрози. Перебування військовополонених японської армії на території СРСР в якості робочої сили було використано для ідеологічної обробки солдатської маси і підготовки діяльного активу для комуністичної пар- тії Японії. Метою політичної індокрінації в кінцевому рахунку можна вважати встановлення радянського контролю над внутрішньою і зов- нішньою політикою Японії і недопущення повного контролю над Японією з боку США.
Ключові слова: Друга світова війна, СРСР, США, Японія, полон, японські військовополонені, політична індокрінація, Квантунська армія.
ОРГАНІЗАЦІЯ КОНТРРОЗВІДУВАЛЬНОГО ЗАБЕЗПЕЧЕННЯ ВНУТРІШНІХ ТА ПРИКОРДОННИХ ВІЙСЬК НА ТЕРИТОРІЇ УКРАЇНИ (1943–1945 рр.)
Authors: Левченко С.М. 
Published: April 2021

У статті на основі архівних документів та спеціальної літератури досліджується організаційно-функціональна побудова органів контр- розвідувального захисту спеціальних (Внутрішніх, Прикордонних та інших) військ Народного комісаріату внутрішніх справ СРСР під час вигнання гітлерівських окупантів з території України.
Розглядається створення у структурі Головного управління контрроз- відки СМЕРШ Наркомату оборони СРСР окремої вертикалі органів за- хисту військ від розвідувально-підривної та диверсійно-терористичної діяльності противника.
Висвітлюються основні чинники оперативної обстановки та загрози, протистояти яким були покликані органи контррозвідувального захисту спеціальних військ Народного комісаріату внутрішніх справ СРСР, ос- новні результати оперативно-службової діяльності військових контр- розвідників.
Ключові слова: військова контррозвідка, війська спеціального призначення, спецслужби, розвідувально-диверсійна діяльність, Друга світова війна.
Sistem Pendukung Keputusan Penentuan Lokasi Strategis Perumahan di Wilayah Kabupaten Asahan
Authors: Harahap Annisa , Rizaldi Rizaldi , Sapta Andy 
Published: April 2021

Abstract: PT. Mitra Zetta Ugraha Lestari is a company engaged in the contractor and developer sector. Company goal to create quality housing with high quality and use value that gives satisfaction to consumers. This study uses the weighted product method. Some of the factors used as measurement tools are density in the population area, land heigh, distance between main roads, distance from shopping centers and market, distance betwen education or school place. The programming language used in this study are visual basic net 2010 and mysql data base Keywords: Decision support system, weighted product method, housing. Abstrak: PT. Mitra Zetta Ugraha Lestari adalah perusahaan yang bergerak di bidang Kontraktor dan Developer. Tujuan perusahaan Mewujudkan perumahan yang berkualitas dan memiliki nilai jualiyang tinggi serta nilai pakaiiyang memberikan kepuasan pada konsumen. Penelitian ini menggunakan metode weighted product. Beberapa faktor yang menjadi alat ukur adalah kepadatanidi area penduduk, ketinggihanitanah, jarak antara jalaniutama, ijarak dengan sentral perbelanjaan/pasar, ijarak antara tempat pendidikan disekolah. Bahasa pemograman yang digunakan pada penelitian ini yaitu Visual Basic NET (VB.NET) 2010 dan MYSQL. Kata kunci: Sistem pendukung keputusan, metode weighted product, perumahan.
Analisis Penyakit Pada Tanaman Cabai Dengan Metode Case Based Reasoning Berbasis Web
Authors: Ernawati Desi , Yusda Riki Andri , Putra Guntur Maha 
Published: April 2021

Abstract:Chili is a production cropthatis much needed by the community. Good care is needed to increase the production of chili plants. Production of chili plants will decrease if the types of diseases that attack are not considered. To find out about chili plant diseases, farmers only look at the disease without knowing the symptoms that appear beforehand so that it will affect the production of chili plants.So that we need experts who understand the symptoms of disease in chili plants.The existence of experts can be replaced by a system designed to detect symptoms of disease in chili plants.The expert system to be designed is web-based using the case-based reasoning method.This expert system is expected to help increase the productivity of chili plants. Keywords:expert system; chili; case-based reasoning; chili plants. Abstrak:Cabai merupakan tanaman produksi yang banyak dibutuhkan oleh masyarakat. Untuk meningkatkan produksi tanaman cabai diperlukan perawatan yang baik. Produksi dari tanaman cabai akan menurun jika tidak diperhatikan jenis penyakit yang menyerang. Untuk mengetahui penyakit tanaman cabai para petani hanya melihat penyakitnya saja tanpa mengetahui terlebih dahulu gejala yang muncul sehingga akan mempengaruhi hasil produksi tanaman cabai. Sehingga diperlukan pakar yang mengerti mengenai gejala penyakit pada tanaman cabai. Keberadaan pakar bisa digantikan oleh sebuah sistem yang dirancang untuk mendeteksi gejala penyakit pada tanaman cabai. Sistem pakar yang akan dirancang berbasis web dengan menggunakan metode case base reasoning. Sistem pakar ini nantinya diharapkan membantu untuk peningkatan produktivitas tanaman cabai. Kata kunci:sistem pakar; cabai; casebasereasoning; tanaman cabai.
Microscopic approach to the description of spin torques in two-dimensional Rashba ferromagnets and antiferromagnets
Authors: Pervishko A A , Yudin D I 
Published: April 2021

Abstract
We review the most significant results obtained in the framework of the microscopic approach to a systematic study of magnetic dynamics in two-dimensional ferromagnetic and antiferromagnetic materials with a strong Rashba spin-orbit coupling. For model systems, we discuss the microscopic derivation of the Gilbert damping tensor, spin-orbit and spin-transfer torques, and symmetric and antisymmetric exchange interactions. It is shown that in both antiferromagnetic and ferromagnetic systems, the presence of a sufficiently strong spin-orbit coupling leads to an anisotropy of spin torques and Gilbert damping. We focus on an analysis of spin-orbit torques in a two-dimensional Rashba antiferromagnet. We also address the possibility of switching the antiferromagnetic order parameter via short current pulses in the plane of the sample.
Using Cu–Zn–Sn–O Precursor to Optimize CZTSSe Thin Films Fabricated by Se Doping With CZTS Thin Films
Authors: Li Qian , Hu Jinpeng , Cui Yaru , Wang Juan , Hao Yu , Shen Tong , Duan Lizhen 
Published: April 2021

The copper–zinc–tin oxide (CZTO) precursor was synthesized to avoid sudden volume expansion from CZTO precursor to Cu2ZnSnS4 (CZTS) thin films and smooth CZTSSe thin-film surfaces without pinholes. The CZTO precursor was prepared by coprecipitation and ball milling to form nanoink of CZTO. Based on the CZTO precursor, the CZTS thin film was fabricated and then selenized to make pinhole-free and flat Cu2ZnSn(S,Se)4(CZTSSe) thin films. The results show that the CZTO precursor greatly contributed to elevating the homologous surface characteristics and crystallinity of CZTSSe thin films by controlling selenium temperature, selenium time, and selenium source temperature. Finally, the conversion efficiency of the CZTSSe thin-film solar cell fabricated from the CZTO precursor was 4.11%, with an open-circuit voltage (Voc) of 623 mV, a short circuit current density (Jsc) of 16.02 mA cm−2, and a fill factor (FF) of 41.2%.
Interleukin-35 Is Involved in Angiogenesis/Bone Remodeling Coupling Through T Helper 17/Interleukin-17 Axis
Authors: Zhang Hui , Li Yuxuan , Yuan Lin , Yao Lutian , Yang Jie , Xia Liping , Shen Hui , Lu Jing 
Published: April 2021

ObjectiveOsteoporosis is a common metabolic bone disease mainly involving bone remodeling and blood vessels. The current study aimed to explore the suppressive role of interleukin (IL)-35 in nuclear factor kappa-B ligand receptor activator (RANKL) and macrophage colony stimulating factor (M-CSF)-induced osteoclastogenesis and angiogenesis in osteoclasts.MethodsOsteoclasts differentiation were induced by incubation of mouse leukemic monocyte/macrophage cell line RAW264.7 cells in the presence of RANKL and M-CSF and was assessed with tartrate-resistant acid phosphatase (TRAP) staining assay. The viability and apoptosis of RAW264.7 was measured using CCK-8 assay and flow cytometry, respectively. The expression of angiogenic genes and proteins were measured using RT-PCR, Western blots and ELISA. The inhibition of Th17/IL-17 axis was examined using plumbagin, which was demonstrated as an IL-17A related signaling pathway inhibitor.ResultsIL-35 inhibited the viability of RAW264.7 cells and promoted the apoptosis of RAW264.7 cells in a dose-dependent manner. Furthermore, IL-35 dose-dependently suppressed the expression of angiogenic markers including VEGF and its receptor. The suppressive effect of IL-35 was confirmed through the activation of Th17/IL-17 axis.ConclusionsWe demonstrated for the first time the immuno-suppressive function of IL-35 on RANKL and M-CSF-induced osteoclastogenesis and angiogenesis through Th17/IL-17 axis. Therapeutic approach involving augmentation of IL-35 regulatory response may serve as a novel treatment option for osteoporosis, especially by suppressing bone resorption and angiogenesis.
Wiskott Aldrich Syndrome: A Multi-Institutional Experience From India
Authors: Suri Deepti , Rikhi Rashmi , Jindal Ankur K. , Rawat Amit , Sudhakar Murugan , Vignesh Pandiarajan , Gupta Anju , Kaur Anit , Sharma Jyoti , Ahluwalia Jasmina , Bhatia Prateek , Khadwal Alka , Raj Revathi , Uppuluri Ramya , Desai Mukesh , Taur Prasad , Pandrowala Ambreen A. , Gowri Vijaya , Madkaikar Manisha R. , Lashkari Harsha Prasada , Bhattad Sagar , Kumar Harish , Verma Sanjeev , Imai Kohsuke , Nonoyama Shigeaki , Ohara Osamu , Chan Koon W. , Lee Pamela P. , Lau Yu Lung , Singh Surjit 
Published: April 2021

BackgroundWiskott Aldrich syndrome (WAS) is characterized by bleeding manifestations, recurrent infections, eczema, autoimmunity, and malignancy. Over the last decade, improved awareness and better in-house diagnostic facilities at several centers in India has resulted in increased recognition of WAS. This study reports collated data across major primary immunodeficiency diseases (PID) centers in India that are involved in care of children with WAS and highlights the varied clinical presentations, genetic profile, and outcomes of patients in India.MethodsRequest to share data was sent to multiple centers in India that are involved in care and management of patients with PID. Six centers provided requisite data that were compiled and analyzed.ResultsIn this multi-institutional cohort, clinical details of 108 patients who had a provisional diagnosis of WAS were received. Of these, 95 patients with ‘definite WAS’ were included Fourteen patients were classified as XLT and 81 patients as WAS. Median age at onset of symptoms of patients was 3 months (IQR 1.6, 6.0 months) and median age at diagnosis was 12 months (IQR 6,48 months). Clinical profile included bleeding episodes (92.6%), infections (84.2%), eczema (78.9%), various autoimmune manifestations (40%), and malignancy (2.1%). DNA analysis revealed 47 variants in 67 cases. Nonsense and missense variants were the most common (28.4% each), followed by small deletions (19.4%), and splice site defects (16.4%). We also report 24 novel variants, most of these being frameshift and nonsense mutations resulting in premature termination of protein synthesis. Prophylactic intravenous immunoglobulin (IVIg) was initiated in 52 patients (54.7%). Hematopoietic stem cell transplantation (HSCT) was carried out in 25 patients (26.3%). Of those transplanted, disease-free survival was seen in 15 patients (60%). Transplant related mortality was 36%. Outcome details were available for 89 patients. Of these, 37% had died till the time of this analysis. Median duration of follow-up was 36 months (range 2 weeks- 12 years; IQR 16.2 months- 70 months).ConclusionsWe report the first nationwide cohort of patients with WAS from India. Bleeding episodes and infections are common manifestations. Mortality continues to be high as curative therapy is not accessible to most of our patients.
Case Report: Complete and Fast Recovery From Severe COVID-19 in a Pemphigus Patient Treated With Rituximab
Authors: Sinagra Jo Linda , Vedovelli Claudio , Binazzi Raffaella , Salemme Adele , Moro Francesco , Mazzanti Cinzia , Didona Biagio , Di Zenzo Giovanni 
Published: April 2021

COVID-19 is characterized by a severe pulmonary disease due to severe acute respiratory syndrome (SARS)-CoV-2 infection. For clinicians involved in the management of patients with chronic autoimmune diseases the risk linked to the conditions itself and to drug-induced immunosuppression during the COVID-19 pandemic is a major topic. Pemphigus is a rare autoimmune blistering disease (AIBD) of the skin and mucous membranes caused by autoantibodies to desmosomal components, desmoglein 1 and 3. Among immunosuppressant therapies, rituximab (RTX) is considered a highly effective treatment with a favorable safety profile, but it induces a prolonged B-cell depletion that can lead to higher susceptibility to infections. For this reason, concerns about its use during the pandemic have been raised. We describe a case of a pemphigus patient in which RTX-induced B cell depletion led to the severe inflammatory phase, whereas corticosteroid treatment allowed a favorable outcome.
The Impact of Serum Anti-neutrophil Cytoplasmic Antibody on Clinical Characteristics and Outcomes in Pediatric-Onset Systemic Lupus Erythematosus Patients
Authors: Gau Chun-Chun , Tseng Min-Hua , Wu Chao-Yi , Yang Huang-Yu , Huang Jing-Long 
Published: April 2021

Background:Systemic lupus erythematosus (SLE), an autoimmune disease, is characterized by the overproduction of autoantibodies. Anti-neutrophil cytoplasmic antibodies (ANCAs) have been recognized in SLE for decades. To date, their association with SLE disease activity, especially in pediatric-onset SLE (pSLE) patients, is limited.Methods:We conducted a retrospective case-control study of pSLE patients with ANCAs from 2010 to 2020. Clinical characteristics, laboratory data, renal histological features, treatment and outcomes were analyzed.Results:A total of 70 pediatric-onset SLE patients (9 ANCA-positive vs. 61 ANCA-negative) with a median age of 12.23 years (age ranging from 4 years to 18 years) at diagnosis were enrolled. Among patients with ANCAs, MPO-ANCA was found in seven and PR3-ANCA in two of those cases. Patients with ANCAs had a tendency to have hematuria compared with those without ANCAs (66 vs. 24.6%, respectively;p= 0.026). Of the 70 SLE patients, 8 with ANCAs and 44 without ANCAs underwent renal biopsies. Patients with ANCAs (25%, 2/8) were more likely to lack the typical full-house pattern in their renal immunofluorescence (IF) staining.Conclusion:pSLE patients with ANCAs tend to have hematuria and an absence of typical IF histology. However, patients with and without ANCAs showed no difference in their clinical presentations and treatment outcomes.
Adverse Health-Related Quality of Life Outcome Despite Adequate Clinical Response to Treatment in Systemic Lupus Erythematosus
Authors: Gomez Alvaro , Qiu Victor , Cederlund Arvid , Borg Alexander , Lindblom Julius , Emamikia Sharzad , Enman Yvonne , Lampa Jon , Parodis Ioannis 
Published: April 2021

Objective: To determine the prevalence of adverse health-related quality of life (HRQoL) outcomes in patients with SLE who achieved an adequate clinical response after a 52-week long standard therapy plus belimumab or placebo, and identify contributing factors.Methods: We included patients who met the primary endpoint of the BLISS-52 (NCT00424476) and BLISS-76 (NCT00410384) trials, i.e., SLE Responder Index 4 (total population: N = 760/1,684; placebo: N = 217/562; belimumab 1 mg/kg: N = 258/559; belimumab 10 mg/kg: N = 285/563). Adverse HRQoL outcomes were defined as SF-36 scale scores ≤ the 5th percentile derived from age- and sex-matched population-based norms, and FACIT-Fatigue scores &lt;30. We investigated factors associated with adverse HRQoL outcomes using logistic regression analysis.Results: We found clinically important diminutions of HRQoL in SLE patients compared with matched norms and high frequencies of adverse HRQoL outcomes, the highest in SF-36 general health (29.1%), followed by FACIT-Fatigue (25.8%) and SF-36 physical functioning (25.4%). Overall, frequencies were higher with increasing age. Black/African American and White/Caucasian patients reported higher frequencies than Asians and Indigenous Americans, while Hispanics experienced adverse HRQoL outcome less frequently than non-Hispanics. Established organ damage was associated with adverse physical but not mental HRQoL outcomes; particularly, damage in the cardiovascular (OR: 2.12; 95% CI: 1.07–4.21; P = 0.032) and musculoskeletal (OR: 1.41; 95% CI: 1.01–1.96; P = 0.041) domains was associated with adverse SF-36 physical component summary. Disease activity showed no impact on HRQoL outcomes. In multivariable logistic regression analysis, addition of belimumab to standard therapy was associated with lower frequencies of adverse SF-36 physical functioning (OR: 0.59; 95% CI: 0.39–0.91; P = 0.016) and FACIT-F (OR: 0.53; 95% CI: 0.34–0.81; P = 0.004).Conclusions: Despite adequate clinical response to standard therapy plus belimumab or placebo, a substantial proportion of SLE patients still reported adverse HRQoL outcomes. While no impact was documented for disease activity, established organ damage contributed to adverse outcome within physical HRQoL aspects and add-on belimumab was shown to be protective against adverse physical functioning and severe fatigue.
Identification of an IRGP Signature to Predict Prognosis and Immunotherapeutic Efficiency in Bladder Cancer
Authors: Zhang Liang-Hao , Li Long-Qing , Zhan Yong-Hao , Zhu Zhao-Wei , Zhang Xue-Pei 
Published: April 2021

BackgroundIdentify immune-related gene pairs (IRGPs) signature related to the prognosis and immunotherapeutic efficiency for bladder cancer (BLCA) patients.Materials and MethodsOne RNA-seq dataset (The Cancer Genome Atlas Program) and two microarray datasets (GSE13507 and GSE31684) were included in this study. We defined these cohorts as training set to construct IRGPs and one immunotherapy microarray dataset as validation set. Identifying BLCA subclasses based on IRGPs by consensus clustering. The Lasso penalized Cox proportional hazards regression model was used to construct prognostic signature and potential molecular mechanisms were analyzed.ResultsThis signature can accurately predict the overall survival of BLCA patients and was verified in the immunotherapy validation set. IRGP-signatures can be used as independent prognostic risk factor in various clinical subgroups. Use the CIBERSORT algorithm to assess the abundance of infiltrating immune cells in each sample, and combine the results of the gene set enrichment analysis of a single sample to explore the differences in the immune microenvironment between IRPG signature groups. According to the results of GSVA, GSEA, and CIBERSORT algorithm, we found that IRGP is strikingly positive correlated with tumor microenvironment (TME) stromal cells infiltration, indicating that the poor prognosis and immunotherapy might be caused partly by enrichment of stromal cells. Finally, the results from the TIDE analysis revealed that IRGP could efficiently predict the response of immunotherapy in BLCA.ConclusionThe novel IRGP signature has a significant prognostic value for BLCA patients might facilitate personalized for immunotherapy.