bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wspominane, wyobrażone, przesunięte. Rosja i Francja w emigracyjnej korespondencji Zinaidy Gippius
Authors: Krycka-Michnowska Iwona 
Published: May 2021

The topic of this article are the letters of Zinaida Gippius from 1920-1945, which permit one to read the images of Russia and France contained therein as the result of the emigration experience. The analysis of correspondence leads to the conclusion that emigration shapes the identity of the writer, who over the years begins to perceive France as her new home and new homeland. However, in creating her autobiographical place, Gippius does not limit herself to one model. In her correspondence permanently there is a tension between Russian and French fate. Next to the aforementioned and Bolshevik Russia there is the picture of a new, imaginary Russia: free, just, based on the principles of brotherhood.
Penerapan Multimedia Interaktif Untuk Meningkatkan Motivasi Belajar Dan Hasil Belajar Siswa Pada Pembelajaran IPA
Authors: Kahfi Martin , Nurparida Nurparida , Srirahayu Erna 
Published: May 2021

Abstract — The purpose of this study is to use interactive multimedia in learning so that teachers can learn abstract information to be more concrete. The method used was an experimental method with a population of class V SDN 2 Keresek and a sample of 21 students. The results showed an increase in learning motivation based on the test results of 0.72 with high interpretation. Furthermore, the increase in student learning outcomes is 0.33 in the medium category. The application of interactive multimedia can increase learning motivation and student learning outcomes in grade V SDN 2 Keresek learning science.Keywords— Learning Outcomes, Learning Motivation, Interactive Multimedia. Abstrak — Tujuan penelitian ini menggunakan multimedia interaktif dalam pembelajaran agar guru dapat mempelajari informasi yang bersifat abstrak menjadi lebih konkret. Metode yang digunakan adalah metode eksperimen dengan populasi kelas V SDN 2 Keresek dan sampel yang diambil sebanyak 21 siswa. Hasil penelitian menunjukan peningkatan peningkatan motivasi belajar berdasarkan hasil uji sebesar 0,72 dengan interpretasi tinggi. Selanjutnya peningkatan hasil belajar siswa sebesar 0,33 dengan kategori sedang. Penerapan multimedia interaktif dapat meningkatkan motivasi belajar dan hasil belajar siswa kelas V SDN 2 Keresek pembelajaran IPA. Kata Kunci : Hasil Belajar, Motivasi Belajar, Multimedia Interaktif.
Prognostic value of CT radiomics in evaluating lymphovascular invasion in rectal cancer: Diagnostic performance based on different volumes of interest
Authors: Ge Yu-Xi , Xu Wen-Bo , Wang Zi , Zhang Jun-Qin , Zhou Xin-Yi , Duan Shao-Feng , Hu Shu-Dong , Fei Bo-Jian 
Published: May 2021

OBJECTIVES: This study aims to evaluate diagnostic performance of radiomic analysis using computed tomography (CT) to identify lymphovascular invasion (LVI) in patients diagnosed with rectal cancer and assess diagnostic performance of different lesion segmentations. METHODS: The study is applied to 169 pre-treatment CT images and the clinical features of patients with rectal cancer. Radiomic features are extracted from two different volumes of interest (VOIs) namely, gross tumor volume and peri-tumor tissue volume. The maximum relevance and the minimum redundancy, and the least absolute shrinkage selection operator based logistic regression analyses are performed to select the optimal feature subset on the training cohort. Then, Rad and Rad-clinical combined models for LVI prediction are built and compared. Finally, the models are externally validated. RESULTS: Eighty-three patients had positive LVI on pathology, while 86 had negative LVI. An optimal multi-mode radiology nomogram for LVI estimation is established. The area under the receiver operating characteristic curves of the Rad and Rad-clinical combined model in the peri-tumor VOI group are significantly higher than those in the tumor VOI group (Rad: peri-tumor vs. tumor: 0.85 vs. 0.68; Rad-clinical: peri-tumor vs. tumor: 0.90 vs 0.82) in the validation cohort. Decision curve analysis shows that the peri-tumor-based Rad-clinical combined model has the best performance in identifying LVI than other models. CONCLUSIONS: CT radiomics model based on peri-tumor volumes improves prediction performance of LVI in rectal cancer compared with the model based on tumor volumes.
Glycosaminoglycans: From Vascular Physiology to Tissue Engineering Applications
Authors: Lepedda Antonio Junior , Nieddu Gabriele , Formato Marilena , Baker Matthew Brandon , Fernández-Pérez Julia , Moroni Lorenzo 
Published: May 2021

Cardiovascular diseases represent the number one cause of death globally, with atherosclerosis a major contributor. Despite the clinical need for functional arterial substitutes, success has been limited to arterial replacements of large-caliber vessels (diameter &gt; 6 mm), leaving the bulk of demand unmet. In this respect, one of the most challenging goals in tissue engineering is to design a “bioactive” resorbable scaffold, analogous to the natural extracellular matrix (ECM), able to guide the process of vascular tissue regeneration. Besides adequate mechanical properties to sustain the hemodynamic flow forces, scaffold’s properties should include biocompatibility, controlled biodegradability with non-toxic products, low inflammatory/thrombotic potential, porosity, and a specific combination of molecular signals allowing vascular cells to attach, proliferate and synthesize their own ECM. Different fabrication methods, such as phase separation, self-assembly and electrospinning are currently used to obtain nanofibrous scaffolds with a well-organized architecture and mechanical properties suitable for vascular tissue regeneration. However, several studies have shown that naked scaffolds, although fabricated with biocompatible polymers, represent a poor substrate to be populated by vascular cells. In this respect, surface functionalization with bioactive natural molecules, such as collagen, elastin, fibrinogen, silk fibroin, alginate, chitosan, dextran, glycosaminoglycans (GAGs), and growth factors has proven to be effective. GAGs are complex anionic unbranched heteropolysaccharides that represent major structural and functional ECM components of connective tissues. GAGs are very heterogeneous in terms of type of repeating disaccharide unit, relative molecular mass, charge density, degree and pattern of sulfation, degree of epimerization and physicochemical properties. These molecules participate in a number of vascular events such as the regulation of vascular permeability, lipid metabolism, hemostasis, and thrombosis, but also interact with vascular cells, growth factors, and cytokines to modulate cell adhesion, migration, and proliferation. The primary goal of this review is to perform a critical analysis of the last twenty-years of literature in which GAGs have been used as molecular cues, able to guide the processes leading to correct endothelialization and neo-artery formation, as well as to provide readers with an overall picture of their potential as functional molecules for small-diameter vascular regeneration.
Case Report: Neonatal Diabetes Mellitus Caused by a Novel GLIS3 Mutation in Twins
Authors: London Shira , De Franco Elisa , Elias-Assad Ghadir , Barhoum Marie Noufi , Felszer Clari , Paniakov Marina , Weiner Scott A. , Tenenbaum-Rakover Yardena 
Published: May 2021

BackgroundMutations in GLIS3 cause a rare syndrome characterized by neonatal diabetes mellitus (NDM), congenital hypothyroidism, congenital glaucoma and cystic kidneys. To date, 14 mutations in GLIS3 have been reported, inherited in an autosomal recessive manner. GLIS3 is a key transcription factor involved in β-cell development, insulin expression, and development of the thyroid, eyes, liver and kidneys.CasesWe describe non-identical twins born to consanguineous parents presenting with NDM, congenital hypothyroidism, congenital glaucoma, hepatic cholestasis, cystic kidney and delayed psychomotor development. Sequence analysis of GLIS3 identified a novel homozygous nonsense mutation, c.2392C&gt;T, p.Gln798Ter (p.Q798*), which results in an early stop codon. The diabetes was treated with a continuous subcutaneous insulin infusion pump and continuous glucose monitoring. Fluctuating blood glucose and intermittent hypoglycemia were observed on follow-up.ConclusionsThis report highlights the importance of early molecular diagnosis for appropriate management of NDM. We describe a novel nonsense mutation of GLIS3 causing NDM, extend the phenotype, and discuss the challenges in clinical management. Our findings provide new areas for further investigation into the roles of GLIS3 in the pathophysiology of diabetes mellitus.
Association Between Diet Quality and Risk of Ovarian and Endometrial Cancers: A Systematic Review of Epidemiological Studies
Authors: Zhang Yu-Hua , Li Zhuo , Tan Ming-Zi 
Published: May 2021

ObjectivesThe relationship between diet quality indices and risk of ovarian and endometrial cancers were unclear. We aimed at conducting a systematic review to evaluate the epidemiological evidence.MethodsEmbase, PubMed, Web of Science and Scopus databases were searched for eligible studies up to December 2020. Epidemiological studies reported the association of the diet quality with risk of ovarian and endometrial cancers were evaluated.ResultsEleven eligible studies were identified, of which six studies were case-control studies, four were cohort studies, and one was case-cohort study. All studies were considered as high-quality with low risk of bias. Seven studies evaluated the association of diet quality with risk of ovarian cancer. Four studies reported null association for diet quality indices such as Healthy Eating Index (HEI)-2005, HEI-2010, Mediterranean Diet Score (MDS) and Recommended Foods Score (RFS). Two studies reported significantly inverse association for Alternate Healthy Eating Index (AHEI)-2010 and Healthy Diet Score (HDS) indices. One study reported significantly increased risk of ovarian cancer associated with higher level of Dietary Guidelines for Americans Index. Dose-response analysis showed pooled relative risks of 0.98 (95%Cl: 0.95, 1.01) and 0.94 (95%Cl: 0.77, 1.13) for each 10 points increase in the HEI-2005 and AHEI-2010 indices. Seven studies evaluated the association of diet quality with risk of endometrial cancer. Three studies reported significantly inverse association of diet quality as assessed by the MDS and Diet Score Quintiles with risk of endometrial cancer. Four studies reported null association for other diet quality indices including HEI-2005, HEI-2010, RFS and HDS. Dose-response analysis showed a pooled relative risk of 0.87 (95%CI: 0.81, 0.93) for one unit increment of the MDS.ConclusionThis study suggests little evidence on the association between diet quality and risk of ovarian cancer. Adherence to high quality diet, as assessed by MDS, might be associated with lower the risk of endometrial cancer.
Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2
Authors: Song Yun-Qing , He Rong-Jing , Pu Dan , Guan Xiao-Qing , Shi Jin-Hui , Li Yao-Guang , Hou Jie , Jia Shou-Ning , Qin Wei-Wei , Fang Sheng-Quan , Ge Guang-Bo 
Published: May 2021

Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the small intestine, has been validated as a key therapeutic target to ameliorate the intestinal toxicity caused by irinotecan. This study aims to discover efficacious CES2 inhibitors from natural products and to characterize the inhibition potentials and inhibitory mechanisms of the newly identified CES2 inhibitors. Following high-throughput screening and evaluation of the inhibition potency of more than 100 natural products against CES2, it was found that the biflavones isolated from Ginkgo biloba displayed extremely potent CES2 inhibition activities and high specificity over CES1 (&gt;1000-fold). Further investigation showed that ginkgetin, bilobetin, sciadopitysin and isoginkgetin potently inhibited CES2-catalyzed hydrolysis of various substrates, including the CES2 substrate-drug irinotecan. Notably, the inhibition potentials of four biflavones against CES2 were more potent than that of loperamide, a marketed anti-diarrhea agent used for alleviating irinotecan-induced intestinal toxicity. Inhibition kinetic analyses demonstrated that ginkgetin, bilobetin, sciadopitysin and isoginkgetin potently inhibited CES2-catalyzed fluorescein diacetate hydrolysis via a reversible and mixed inhibition manner, with Ki values of less than 100 nM. Ensemble docking and molecular dynamics revealed that these biflavones could tightly and stably bind on the catalytic cavity of CES2 via hydrogen bonding and π-π stacking interactions, while the interactions with CES1 were awfully poor. Collectively, this study reports that the biflavones isolated from Ginkgo biloba are potent and highly specific CES2 inhibitors, which offers several promising lead compounds for developing novel anti-diarrhea agent to alleviate irinotecan-induced diarrhea.
The Heterogenous Effect of COVID-19 on Liver Transplantation Activity and Waitlist Mortality in the United States
Authors: Yuan Qing , Haque Omar , Coe Taylor M. , Markmann James F. 
Published: May 2021

Background: The COVID-19 pandemic curtailed the practice of liver transplantation (LT), which lacks a temporizing life-saving measure for candidates on the waitlist.Aims/Objectives: The objective of this research was to (1) determine the effect of decreased LT activity on waitlist mortality in the United States and (2) assess if this effect was homogenous across the country.Methods: We conducted a retrospective, cross-sectional analysis utilizing United Network for Organ Sharing (UNOS) data assessing 3,600 liver transplants from January 1, 2020 to June 2, 2020. COVID-19 incidence data was taken directly from the New York Times case count.Results: During weeks 10 to 15 of 2020, there was a 38% reduction in the number of LTs performed nationally, which was temporally associated with a transient 97% increase in waitlist mortality. When stratified by UNOS region, waitlist mortality was inversely correlated with the number of LTs performed in all 11 regions. However, the range of the association strength (r) was large (Pearson correlation coefficient range: −0.73 to −0.01).Conclusion: Interruptions in LT activity due to COVID-19 were associated with rapid increases in waitlist mortality, and these effects were unevenly distributed among candidates across the United States. The transplant community can utilize these results to mitigate inequalities in transplant allocation between UNOS regions and advocate for the uninterrupted practice of LT should another pandemic surge or COVID-19 variant arise.
Computational Treatment Simulations to Assess the Need for Personalized Tamoxifen Dosing in Breast Cancer Patients of Different Biogeographical Groups
Authors: Mueller-Schoell Anna , Michelet Robin , Klopp-Schulze Lena , van Dyk Madelé , Mürdter Thomas E. , Schwab Matthias , Joerger Markus , Huisinga Wilhelm , Mikus Gerd , Kloft Charlotte 
Published: May 2021

Tamoxifen is used worldwide to treat estrogen receptor-positive breast cancer. It is extensively metabolized, and minimum steady-state concentrations of its metabolite endoxifen (CSS,min ENDX) >5.97 ng/mL have been associated with favorable outcome. Endoxifen formation is mediated by the enzyme CYP2D6, and impaired CYP2D6 function has been associated with lower CSS,min ENDX. In the Women’s Healthy Eating and Living (WHEL) study proposing the target concentration, 20% of patients showed subtarget CSS,min ENDX at tamoxifen standard dosing. CYP2D6 allele frequencies vary largely between populations, and as 87% of the patients in the WHEL study were White, little is known about the risk for subtarget CSS,min ENDX in other populations. Applying pharmacokinetic simulations, this study investigated the risk for subtarget CSS,min ENDX at tamoxifen standard dosing and the need for dose individualization in nine different biogeographical groups with distinct CYP2D6 allele frequencies. The high variability in CYP2D6 allele frequencies amongst the biogeographical groups resulted in an up to three-fold difference in the percentages of patients with subtarget CSS,min ENDX. Based on their CYP2D6 allele frequencies, East Asian breast cancer patients were identified as the population for which personalized, model-informed precision dosing would be most beneficial (28% of patients with subtarget CSS,min ENDX).
Corporate Philanthropy Strategy and Sustainable Development Goals
Authors: Yu Hui-Cheng , Kuo Lopin 
Published: May 2021

This paper investigates the charitable giving of Chinese firms from the perspectives of four sustainable development goals (SDGs), including Economy, Operation, Harmony, and Management. By converting corporate financial data into four independent variables, namely Economy, Operation, Harmony, and Management, this study explores philanthropic giving for SDGs. The empirical evidence shows that corporate philanthropy has a significant and positive effect on Economy, Operation and Harmony, and it is negatively related to Management. This study finds that the sample firms would undertake some social responsibilities for the economic and political benefits of legitimization or corporate philanthropy.
CREATING OF THE ARCHITECTURAL ENSEMBLE OF THE ZNAMENSKAYA STATION SQUARE IN ST PETERSBURG
Authors: Petuhova N. 
Published: May 2021

The history of the creating of the Znamenskaya station square (now the Vosstaniya Square) in St. Petersburg is considered. The square appeared in front of the station of the first main railway in Russia, which connected two capitals - the old and the new - Moscow and St. Petersburg (from 1855 - Nikolaevskaya, from 1923 - October railway). The state status of the road also determined the status of the station square in front of its main station in St. Petersburg. The square was created as one of the main urban planning ensembles of the city, the formation of which was given attention at the highest level.
Extensive archival sources have been studied, extracts and graphic materials from which are presented in this article. Based on the historical and urban planning analysis, the main factors that influenced the choice of the location of the station of the St. Petersburg-Moscow railway and its station square in St. Petersburg were identified.
It is shown that Znamenskaya Square is one of the last urban planning ensembles of St. Petersburg, created centrally on the basis of classical principles according to a single project, including the entire front of the buildings that form it.
It has been established that Znamenskaya Square is a unique urban planning phenomenon, since in the history of 19th century architecture, the fact of the creation of the station square, conceived as a single regular ensemble, is no longer known
Expression of ACE2 in the Intact and Acutely Injured Kidney
Authors: Nath Karl A. , Singh Raman Deep , Grande Joseph P. , Garovic Vesna D. , Croatt Anthony J. , Ackerman Allan W. , Barry Michael A. , Agarwal Anupam 
Published: May 2021

Abstract

Key Points

The healthy kidney prominently expresses angiotensin-converting enzyme 2 (ACE2) mRNA, protein, and activity, with ACE2 protein abundantly displayed in proximal tubules.Renal ACE2 expression decreases after ischemic AKI but is induced by LPS in a heme oxygenase-1-dependent manner.ACE2 induction/angiotensin (1–7) and angiotensin (1–7) may offer therapeutic approaches for AKI without or with coronavirus disease 2019, respectively.

Background
The actions of angiotensin-converting enzyme 2 (ACE2) oppose those of the renin-angiotensin-aldosterone system. ACE2 may be a cytoprotectant in some tissues. This study examined ACE2 expression in models of AKI.

Methods
ACE2 mRNA and protein expression and ACE2 activity were assessed in murine ischemic AKI. Renal ACE2 mRNA expression was evaluated in LPS-induced AKI in wild-type (C57BL/6J) mice, in heme oxygenase-1+/+ and heme oxygenase-1−/− mice, and after unilateral ureteral obstruction (UUO) in wild-type mice. The effect of sex and age on renal ACE2 protein expression was also assessed.

Results
In ischemic AKI, ACE2 mRNA and protein expression and ACE2 activity were reduced as compared with such indices in the intact kidney. In ischemic AKI, ACE2, which, in health, is prominently expressed in the tubular epithelium, especially proximal tubules, is decreased in expression in these segments. Decreased ACE2 expression in AKI did not reflect reduced GFR, because ACE2 mRNA expression was unaltered after UUO. LPS induced renal ACE2 mRNA expression in wild-type mice, but this effect did not occur in heme oxygenase-1–deficient mice. In ischemic and LPS-induced AKI, renal expression of the Mas receptor was increased. In the intact kidney, renal ACE2 protein expression decreased in female mice as compared with male mice, but was unaltered with age.

Conclusion
We conclude that renal ACE2 expression is decreased in ischemic AKI, characterized by decreased GFR and abundant cell death, but is upregulated in LPS-induced AKI, an effect requiring heme oxygenase-1. Determining the significance of ACE2 expression in experimental AKI merits further study. We suggest that understanding the mechanism underlying ACE2 downregulation in AKI may offer insights relevant to COVID-19: ACE2 expression is downregulated after ACE2 mediates SARS-CoV-2 cellular entry; such downregulation is proinflammatory; and AKI commonly occurs and determines outcomes in COVID-19.
THE EFFECT OF JOB STRESS, JOB SATISFACTION AND ORGANIZATIONAL COMMITMENT ON PERFORMANCE
Authors: Yanner Yanner , Bernarto Innocentius , Wuisan Dewi 
Published: May 2021

Abstract. This study aims to examine the negative effect of job stress on organizational commitment; positive effect of job satisfaction on organizational commitment; negative effect of job stress on performance; positive effect of job satisfaction on performance; positive effect of organizational commitment on performance. The target population were all 45 JBP High School teachers. The sampling technique used was saturated or census samples. The data was collected through a questionnaire and analyzed using Partial Least Squares - Structural Equation Modeling (PLS-SEM) approach using SmartPLS program. The results showed that the job stress negatively affected organizational commitment and performance. In addition, the organizational commitment and job satisfaction had a positive effect on performance.Keywords: Job Stress, Job Satisfaction, Organizational Commitment, Performance Abstrak. Penelitian ini bertujuan untuk menguji efek negatif dari stres kerja pada komitmen organisasi; pengaruh positif kepuasan kerja terhadap komitmen organisasi; efek negatif dari stres kerja pada kinerja; efek positif kepuasan kerja terhadap kinerja; efek positif dari komitmen organisasi terhadap kinerja. Populasi target adalah semua 45 guru SMA JBP. Teknik pengambilan sampel yang digunakan adalah sampel jenuh atau sensus. Data dikumpulkan melalui kuesioner dan dianalisis menggunakan pendekatan Partial Least Squares - Structural Equation Modeling (PLS-SEM) menggunakan program SmartPLS. Hasil penelitian menunjukkan bahwa stres kerja berpengaruh negatif terhadap komitmen dan kinerja organisasi. Selain itu, komitmen organisasi dan kepuasan kerja berpengaruh positif terhadap kinerja.Kata Kunci: Stres Kerja, Kepuasan Kerja, Komitmen Organisasi, Performa