bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt
Authors: Radunski Ulf K. , Kluwe Johannes , Klein Malte , Galante Antonio , Lund Gunnar K. , Sinning Christoph , Bohnen Sebastian , Tahir Enver , Starekova Jitka , Bannas Peter , Stehning Christian , Adam Gerhard , Lohse Ansgar W. , Blankenberg Stefan , Muellerleile Kai , Benten Daniel 
Published: June 2021

AbstractTransjugular intrahepatic portosystemic shunt (TIPS) reduces portal hypertension in patients with liver cirrhosis. The exact cardiac consequences of subsequent increase of central blood volume are unknown. Cardiovascular magnetic resonance (CMR) imaging is the method of choice for quantifying cardiac volumes and ventricular function. The aim of this study was to investigate effects of TIPS on the heart using CMR, laboratory, and imaging cardiac biomarkers. 34 consecutive patients with liver cirrhosis were evaluated for TIPS. Comprehensive CMR with native T1 mapping, transthoracic echocardiography, and laboratory biomarkers were assessed before and after TIPS insertion. Follow-up (FU) CMR was obtained in 16 patients (47%) 207 (170–245) days after TIPS. From baseline (BL) to FU, a significant increase of all indexed cardiac chamber volumes was observed (all P < 0.05). Left ventricular (LV) end-diastolic mass index increased significantly from 45 (38–51) to 65 (51–73) g/m2 (P =  < 0.01). Biventricular systolic function, NT-proBNP, high-sensitive troponin T, and native T1 time did not differ significantly from BL to FU. No patient experienced cardiac decompensation following TIPS. In conclusion, in patients without clinically significant prior heart disease, increased cardiac preload after TIPS resulted in increased volumes of all cardiac chambers and eccentric LV hypertrophy, without leading to cardiac impairment during follow-up in this selected patient population.
Pharmacologic modulation of 5-fluorouracil by folinic acid and high-dose pyridoxine for treatment of patients with digestive tract carcinomas
Authors: Machover David , Almohamad Wathek , Castagné Vincent , Desterke Christophe , Gomez Léa , Gaston-Mathé Yann , Boucheix Claude , Goldschmidt Emma 
Published: June 2021

AbstractSupplementation of cancer cells exposed to 5-fluorouracil (FUra) and folinic acid (FA) with high concentration pyridoxal 5′-phosphate, the cofactor of vitamin B6, potentiates the cytotoxicity of FUra in a synergistic interaction mode. We report a pilot study in 13 patients with previously untreated advanced carcinoma of the digestive tract to assess the impact of high-dose pyridoxine (PN) on the antitumor activity of regimens comprising FUra and FA. Five patients had colorectal adenocarcinoma (CRC); 5 had pancreas adenocarcinoma (PC); and 3 had squamous cell carcinoma of the esophagus (EC). Patients with CRC and with PC received oxaliplatin, irinotecan, FUra and FA, and patients with EC had paclitaxel, carboplatin, FUra and FA. PN iv from 1000 to 3000 mg/day preceded each administration of FA and FUra. Eleven patients responded. Two patients with CRC attained CRs and 3 had PRs with reduction rates ≥ 78%. Two patients with PC attained CRs, and 2 had PRs with reduction rates ≥ 79%. Responders experienced disappearance of most metastases. Of 3 patients with EC, 2 attained CRs. Median time to attain a response was 3 months. Unexpected toxicity did not occur. Results suggest that high-dose vitamin B6 enhances antitumor potency of regimens comprising FUra and FA.
Monocyte Distribution Width (MDW) as novel inflammatory marker with prognostic significance in COVID-19 patients
Authors: Riva Giovanni , Castellano Sara , Nasillo Vincenzo , Ottomano Anna Maria , Bergonzini Giuliano , Paolini Ambra , Lusenti Beatrice , Milić Jovana , De Biasi Sara , Gibellini Lara , Cossarizza Andrea , Busani Stefano , Girardis Massimo , Guaraldi Giovanni , Mussini Cristina , Manfredini Rossella , Luppi Mario , Tagliafico Enrico , Trenti Tommaso 
Published: June 2021

AbstractMonocyte Distribution Width (MDW), a new cytometric parameter correlating with cytomorphologic changes occurring upon massive monocyte activation, has recently emerged as promising early biomarker of sepsis. Similar to sepsis, monocyte/macrophage subsets are considered key mediators of the life-threatening hyper-inflammatory disorder characterizing severe COVID-19. In this study, we longitudinally analyzed MDW values in a cohort of 87 COVID-19 patients consecutively admitted to our hospital, showing significant correlations between MDW and common inflammatory markers, namely CRP (p < 0.001), fibrinogen (p < 0.001) and ferritin (p < 0.01). Moreover, high MDW values resulted to be prognostically associated with fatal outcome in COVID-19 patients (AUC = 0.76, 95% CI: 0.66–0.87, sensitivity 0.75, specificity 0.70, MDW threshold 26.4; RR = 4.91, 95% CI: 1.73–13.96; OR = 7.14, 95% CI: 2.06–24.71). This pilot study shows that MDW can be useful in the monitoring of COVID-19 patients, as this innovative hematologic biomarker is: (1) easy to obtain, (2) directly related to the activation state of a fundamental inflammatory cell subset (i.e. monocytes, pivotal in both cytokine storm and sepsis immunopathogenesis), (3) well correlated with clinical severity of COVID-19-associated inflammatory disorder, and, in turn, (4) endowed with relevant prognostic significance. Additional studies are needed to define further the clinical impact of MDW testing in the management of COVID-19 patients.
Variable-rate in corn sowing for maximizing grain yield
Authors: da Silva Eder Eujácio , Baio Fábio Henrique Rojo , Kolling Daniel Fernando , Júnior Renato Schneider , Zanin Alex Rogers Aguiar , Neves Danilo Carvalho , Fontoura João Vítor Pereira Ferreira , Teodoro Paulo Eduardo 
Published: June 2021

AbstractSowing density is one of the most influential factors affecting corn yield. Here, we tested the hypothesis that, according to soil attributes, maximum corn productivity can be attained by varying the seed population. Specifically, our objectives were to identify the soil attributes that affect grain yield, in order to generate a model to define the optimum sowing rate as a function of the attributes identified, and determine which vegetative growth indices can be used to predict yield most accurately. The experiment was conducted in Chapadão do Céu-GO in 2018 and 2019 at two different locations. Corn was sown as the second crop after the soybean harvest. The hybrids used were AG 8700 PRO3 and FS 401 PW, which have similar characteristics and an average 135-day cropping cycle. Tested sowing rates were 50, 55, 60, and 65 thousand seeds ha−1. Soil attributes evaluated included pH, calcium, magnesium, phosphorus, potassium, organic matter, clay content, cation exchange capacity, and base saturation. Additionally, we measured the correlation between the different vegetative growth indices and yield. Linear correlations were obtained through Pearson’s correlation network, followed by path analysis for the selection of cause and effect variables, which formed the decision trees to estimate yield and seeding density. Magnesium and apparent electrical conductivity (ECa) were the most important soil attributes for determining sowing density. Thus, the plant population should be 56,000 plants ha−1 to attain maximum yield at ECa values > 7.44 mS m−1. In addition, the plant population should be 64,800 plants ha−1 at values < 7.44 mS m−1 when magnesium levels are greater than 0.13 g kg−1, and 57,210 plants ha−1 when magnesium content is lower. Trial validation showed that the decision tree effectively predicted optimum plant population under the local experimental conditions, where yield did not significantly differ among populations.
Nanoscale spatial dependence of avidity in an IgG1 antibody
Authors: Jendroszek Agnieszka , Kjaergaard Magnus 
Published: June 2021

AbstractAntibodies are secreted proteins that are crucial to recognition of pathogens by the immune system and are also efficient pharmaceuticals. The affinity and specificity of target recognition can increase remarkably through avidity effects, when the antibody can bind a multivalent antigen through more than one epitope simultaneously. A key goal of antibody engineering is thus to optimize avidity, but little is known about the nanoscale spatial dependence of avidity in antibodies. Here, we develop a set of anti-parallel coiled-coils spanning from 7 to 20 nm and validate their structure using biophysical techniques. We use the coiled-coils to control the spacing between two epitopes, and measure how antigen spacing affects the stability of the bivalent antibody:antigen complex. We find a maximal avidity enhancement at a spacing of 13 nm. In contrast to recent studies, we find the avidity to be relatively insensitive to epitope spacing near the avidity maximum as long as it is within the spatial tolerance of the antibody. We thus only see a ~ twofold variation of avidity in the range from 7 to 20 nm. The coiled-coil systems developed here may prove a useful protein nanocaliper for profiling the spatial tolerance and avidity profile of bispecific antibodies.
Low‐light image enhancement based on exponential Retinex variational model
Authors: Chen Xinyu , Li Jinjiang , Hua Zhen 
Published: June 2021

AbstractAiming at the problems of residual noise, low contrast, and limited detail information caused by low‐light images, this paper proposes a new Retinex variational model. According to Retinex theory, it is necessary to estimate the illumination and reflectance components decomposed from the original image. In order to better maintain the edge information, texture richness, and prevent artefacts, the exponential forms of local variation deviation and total variation are used as illumination prior and reflectance prior, respectively, and mixed norms are used to constrain them, so as to deal with the illumination information and texture details of the image more effectively, and then use the bright channel prior to improve the colour reproduction sense of the original image, thereby constructing the objective function, and finally using the alternating iterative optimization method to find the optimal solution to the proposed model. Experiments show that compared with other existing image enhancement methods, the method proposed here improves the contrast of the image, overcomes the phenomenon of halo artefacts and colour distortion, is more consistent with human vision, and produces better results in terms of quantitative performance.
A review on key challenges in intelligent vehicles: Safety and driver‐oriented features
Authors: Hu Lin , Zhou Xiqin , Zhang Xin , Wang Fang , Li Qiqi , Wu Wenguang 
Published: June 2021

AbstractThe huge advantages of intelligent vehicles (IVs) in improving road safety and operating efficiency have become a research focus in the industry. IVs have made significant progress in recent years, but it is still face great challenges in order to be accepted by users on a large scale. In this regard, the authors propose that the research of IVs can be developed along the lines of safety, comfort and economy, gradually overcoming existing dilemmas. First of all, security is the most basic requirement of IVs. The authors sort out the key technologies and challenges of the basic architecture of IVs, and propose existing attack and defences strategies for IVs information security technology. Secondly, comfort is more about people's subjective feelings. From two aspects of physiological comfort and psychological comfort, the paper studies the anthropomorphic decision‐making to overcome the mechanized speed control, human computer interaction design, personalized driving style and ethical decision‐making methods. Then, aiming at the micro‐ and macro‐levels of economy, it outlines technologies such as economic driving behavioural, collaborative control of people, vehicles and roads and IVs sharing. Finally, the authors summarized the challenges and future development directions in the three stages of IVs development.
Erwartungen von Patient*innen mit unspezifischen Kreuzschmerzen an die physiotherapeutische Behandlung im ambulanten Setting
Authors: Butry Lionel , Förster Annemarie , Thiel Christian , Kopkow Christian 
Published: June 2021

Zusammenfassung
Hintergrund Physiotherapeutische Behandlungen sollten die Erwartungen von Patient*innen berücksichtigen. Es ist unklar, welche Erwartungen Menschen mit unspezifischen Kreuzschmerzen an die physiotherapeutische Behandlung in Deutschland haben.
Ziel Ermittlung der Erwartungen von erwachsenen Patient*innen mit unspezifischen Kreuzschmerzen bezüglich physiotherapeutischer Therapieziele und -inhalte in Deutschland.
Methode Im Rahmen einer Querschnittsstudie wurden Patient*innen mit unspezifischen Kreuzschmerzen mittels Fragebogen befragt. Es wurden Erfahrungen mit der bisherigen physiotherapeutischen Behandlung und Erwartungen an die Therapieinhalte mit einer 6-Punkte-Likert-Skala, Erwartungen an den posttherapeutischen Gesundheitszustand mit einer numerischen Rating-Skala (NRS) erhoben.
Ergebnisse In die deskriptive Analyse flossen 224 Datensätze ein. Die Befragten stimmten eher bis sehr zu, eine klinische Untersuchung, gemeinsame Zielsetzung, Edukation über die Ursache des Gesundheitsproblems, den Beschwerdeverlauf und das Selbstmanagement zu erwarten. Nach Behandlungsabschluss erwarteten sie eine niedrige Schmerzintensität, eine geringe Einschränkung der ADL und beruflichen Teilhabe sowie keine Einschränkung der sozialen Teilhabe.
Schlussfolgerung Patient*innen mit unspezifischen Kreuzschmerzen haben hohe Erwartungen an den posttherapeutischen Gesundheitszustand. Es gibt eindeutige Erwartungen an Therapieinhalte.
Infektionen an der Hand – eine Übersichtsarbeit
Authors: Bickert Berthold , Müller Camillo T. , Harhaus Leila 
Published: June 2021

ZusammenfassungDiese Arbeit gibt einen Überblick über die Häufigkeit, Art und Ursache von Infektionen an der Hand sowie Risikofaktoren für und Differenzialdiagnosen zu Handinfektionen.
Indikationen und Grenzen der konservativen Therapie bei Infektionen an der Hand
Authors: Schwalfenberg Nico , Richter Martin 
Published: June 2021

ZusammenfassungDie Behandlung von Infektionen der Hand ist ein wichtiger Bestandteil des handchirurgischen Alltags. Trotz der Entwicklung verschiedener Antibiotikapräparate bleibt die Operation ein wichtiger Teil der Therapie. Jedoch kann in ausgewählten Fällen eine konservative Therapie indiziert sein, solange eine konsequente Kontrolle gewährleistet ist. Zielführend ist eine sorgfältige Untersuchung und für die Kalkulation des Erregerspektrums eine genaue Anamnese inkl. Beruf, Hobby, Mensch-Tierkontakt, Auslandsaufenthalt und Nebenerkrankungen. Neben der Wahl des geeigneten Antibiotikums sind eine zeitlich limitierte Immobilisation, körperliche Schonung, Verbandanlage und eine Schmerztherapie wichtige Bestandteile der konservativen Therapie. Für die Therapieentscheidung ist die Art der Infektion und die Beachtung der Vorerkrankungen des Patienten wichtig, da bei Immunsuppression mit einer erhöhten Gefahr für Komplikationen, Mischinfektionen und atypischen Erregern gerechnet werden muss. Klassische Indikationen für eine konservative Therapie stellen das Erysipel, die lokale begrenzte Phlegmone mit Lymphangitis, Frühstadien des Panaritiums und der Paronychie dar. Weitere seltenere Indikation sind u. a. Schweinerotlauf, digitale Herpesinfektion und Pilzinfektionen. Nicht geeignet sind in der Regel eine Symptomdauer über 2 Tage, Abszesse, ausgedehnte Phlegmonen (v. a. der Beugesehnenscheide), nekrotisierende Fasziitiden und Gelenkempyeme.
Bildgebende Diagnostik erregerbedingter Entzündungen der Hand
Authors: Fodor Stefan Georg , Christopoulos Georgios , Mühldorfer-Fodor Marion , Lehmkuhl Lukas 
Published: June 2021

ZusammenfassungDie klinischen Zeichen einer Infektion an der Hand können anfangs oder beim chronischen Verlauf subtil sein. Aber auch bei einem fortgeschrittenen Befund ist oft schwer abzuschätzen, inwieweit Weichteile, Gelenke und Knochen betroffen sind. Der folgende Artikel zeigt die diagnostischen Möglichkeiten der radiologischen Bildgebung. Die Röntgenaufnahme der betroffenen Region stellt die Basisdiagnostik dar. Die Sonografie gibt Aufschluss über eine Abszess- und Ergussbildung zur Abgrenzung gegenüber diffusen Flüssigkeitseinlagerungen. Beide stehen in der Regel zeitnah zur Verfügung. Bei chronischen Prozessen und unklaren Befunden kommt die MRT zum Einsatz, bei knöcherner Beteiligung und Verdacht auf eine Osteomyelitis bei liegenden Implantaten liefert die CT wichtige Informationen.
Fingerend- und Fingermittelgelenksinfektionen: 4-wöchige Ruhigstellung zwischen Primäreingriff mit Gelenkresektion und sekundärer Arthrodese ausreichend
Authors: Küenzlen Lara , Vorderwinkler Karl-Paul , Stievano Simona , Mühldorfer-Fodor Marion , van Schoonhoven Jörg , Prommersberger Karl-Josef 
Published: June 2021

Zusammenfassung
Hintergrund Unser 2011 veröffentlichtes Behandlungsregime bei Infektionen eines Fingermittel- und Fingerendgelenkes sah bei bereits vorhandenem Knorpelschaden die Resektion des betroffenen Gelenkes mit nachfolgender Ruhigstellung mittels Fixateur externe für 6 Wochen bis zur sekundären Arthrodese vor. 2013 reduzierten wir im Rahmen einer prospektiven Studie die Ruhigstellungsdauer auf 4 Wochen.
Ziel Die vorliegende Arbeit untersucht die Auswirkungen der Verkürzung der Ruhigstellung von 6 auf 4 Wochen zwischen Primäreingriff und sekundärer Arthrodese bei einer bakteriellen Infektion eines Fingermittel- und Endgelenkes.
Patienten und Methoden 20 Patienten, bei denen aufgrund eines Infektes eines Fingermittel- oder Endgelenkes zwischen März 2013 und Juli 2014 primär eine Gelenkresektion mit sekundärer Arthrodese nach einer verkürzten Immobilisierung von 4 Wochen erfolgte, wurden nach median 5,7 (4,6–10,5) Monaten klinisch und radiologisch nachuntersucht. Die Ergebnisse wurden statistisch ausgewertet und mit den Ergebnissen von 2011 verglichen.
Ergebnisse Die Reduktion der Ruhigstellung von 6 auf 4 Wochen führte zu keinem signifikanten Unterschied in der Revisionsrate (p = 0,148). Bei 18/20 Patienten war die Infektion nach 4 Wochen zuverlässig saniert und die folgende Arthrodese konsolidierte. Eine Patientin benötigte eine Revision aufgrund eines persistierenden Infektes, ein zweiter Patient erhielt eine Revision der Arthrodese aufgrund einer Materialdislokation. Das Bewegungsausmaß des betroffenen Fingers betrug 147,5 (30–220)°. Mit einer Griffkraft von 26 (4–64) kg erreichte die operierte Hand 88,5 (47,8–223,1) % der Gegenseite. Die subjektive Handfunktion war gut (DASH-Score 37,9 (3,3–71,7), Krimmer-Score 2 (1–4)). Eine anhaltende Schmerzsymptomatik in Ruhe (VAS 0 (0–3)) und bei Belastung (VAS 1,3 (0–7)) bestand nicht. Eine Kälteempfindlichkeit wurde von 50 % der Patienten bejaht. Die Ergebnisse der Nachuntersuchung von 2011 ergaben vergleichbare Werte (ROM des betroffenen Fingers 142,5 (30–220)°, Griffkraft 95 (33–127)%, DASH-Score 23,3 (0–130), Krimmer Score 2 (1–4), VAS Ruhe 0 (0–7), VAS Belastung 4,5 (0–9), Kälteempfindlichkeit bei 41 % der 27 Patienten).
Schlussfolgerung Eine Verkürzung der Ruhigstellungszeit zwischen Primäreingriff mit Gelenkresektion und sekundärer Arthrodese bei Infekt des Fingermittel- und Fingerendgelenkes von 6 auf 4 Wochen hat keine negativen Auswirkungen. Die beschriebene Therapie führt zu einer sicheren Infektionsausheilung mit guter postoperativer Funktion des Fingers und geringer, subjektiver Beschwerdesymptomatik.
Two-color interferometer for study of dense low-ionized plasma on the target in high-power pulse linear accelerator
Authors: Danilov V. V. , Skovorodin D. I. , Popov S. S. , Burdakov A. V. , Trunev Yu. A. , Kurkuckekov V. V. , Anikeev M. A. , Atlukhanov M. G. , Kolesnikov P. A. , Politov V. Yu. 
Published: June 2021

A two-color infrared interferometer has been developed for the investigation of high-density weakly ionized tantalum plasma in x-ray complexes based on linear induction accelerators (1.6 kA electron beam current, 4.6 MeV energy, and 100 ns pulse duration). Simultaneous probing at two different wavelengths makes it possible to independently measure the density of neutral and electron components. The interferometer uses wavelength values of 1.064 µm (Nd:YAG laser) and 10.6 µm (CO2 laser). To attenuate the effect of sample beam refraction in inhomogeneous plasma, the interferometer used a refraction suppression scheme composed of spherical mirrors focusing the object beam into the region occupied by the plasma. In addition, the power of the sample beam transmitted through the plasma was controlled in order to analyze whether there was a distortion of the interference pattern because of strong sample beam refraction and absorption in the plasma cloud. To calibrate the initial phase shift of the probe radiation, a movable mirror mounted on a piezoelectric element and oscillating according to a harmonic law with amplitude greater than the laser wavelengths was used. In initial experiments, the parameters of target plasma registered by this interferometer are as follows: the linear density of neutrals reached 1.5 · 1017 cm−2, and the degree of ionization was of the order of 10−2. The target plasma expansion velocity is determined as ∼6 km/s.
Spatiotemporally resolved subcellular phosphoproteomics
Authors: Liu Yanjun , Zeng Ruxin , Wang Ruixuan , Weng Yicheng , Wang Ruixiang , Zou Peng , Chen Peng R. 
Published: June 2021

Significance
As one of the most important post-translational modifications, phosphorylation is both highly abundant and dynamically regulated in cells. Characterizing subcellular phosphoproteome with high temporal resolution should shed light on their contributions to diverse cellular processes. By integrating an activatable proximity labeling enzyme with an orthogonal phosphorylation enrichment scheme, we have developed the SubMAPP strategy for mapping the phosphorylation dynamics of subcellular proteome in living systems. The high sensitivity of SubMAPP enabled the identification of phosphoproteins and phosphorylation sites in the endoplasmic reticulum (ER), revealing ER-to-mitochondria protein translocation under ER stress.
Effect of N and P fertilization on the allocation and fixation of photosynthesized carbon in paddy soil
Authors: Zhran Mostafa , Ge Tida , Tong Yaoyao , Zhu Zhenke , Deng Yangwu , Fahmy Ahmed , Chen Ming , Lynn Tin Mar , Wu Jinshui , Gunina Anna 
Published: June 2021

ABSTRACT

Potted rice seedlings independently treated with N, P, and NP were continuously
13
CO2 labeled to investigated the influence of N and P application on the contribution of photosynthesized C to the rhizosphere versus bulk soil and particulate organic matter (POM) versus mineral fraction (MIN). N and NP enhanced net assimilated
13
C on day 14 (D14), with maximum C assimilation occurring on day 22 (D22) under NP. Aboveground biomass retained more
13
C than belowground biomass for all treatments. 13C incorporation into the rhizosphere exceeded that in bulk soil, with the maximum (6–10%) found under N addition. Newly assimilated
13
C incorporated into POM increased in the rhizosphere under N and NP conditions, whereas MIN remained largely unaffected.
13
C-MBC proportion in the total microbial biomass C (MBC) pool revealed that N and NP stimulated microbial activity to a greater degree than P. The main portion of
13
C in the rhizosphere and bulk soil was found in POM on D14, which decreased over time due to microbial utilization. Contrastingly, root-derived
13
C in the MIN remained unchanged between sampling days, which indicates that the stabilization of rhizodeposits in this fraction might be the potential mechanism underlying SOM sequestration in paddy soils.