bluuebunny/crossref_metadata_2025_split huggingface dataset:
RNF168 suppresses the cancer stem cell‐like traits of nonsmall cell lung cancer cells by mediating RhoC ubiquitination
Authors: Rong Guoxiang , Pan Zhongjun , Ding Ming , Wang Lihui 
Published: December 2021

AbstractThe critical roles of E3 ubiquitin ligase RNF168 have been widely revealed in various tumors, however, its roles in lung cancer progression are still confusing. Here, we found that RNF168 expression is positively correlated with the overall survival, first‐progression survival, and postprogression survival of lung adenocarcinoma, but not correlated with these survivals of squamous cell carcinoma of lung. Furthermore, it was shown that RNF168 mRNA expression is lowly expressed in lung adenocarcinoma tissues, but highly expressed in squamous cell carcinoma of lung. Functional experiments indicated that RNF168 overexpression significantly suppressed the cancer stem cell (CSC)—like traits of nonsmall cell lung cancer (NSCLC) cells, as characterized by the attenuation of sphere‐formation ability, ALDH activity, and the expression of lung CSC markers. Mechanistic studies demonstrated that RNF168 facilitated the ubiquitination of RhoC, which had been considered as a fascinating target for CSCs, and thus promoted RhoC protein degradation. Notably, RNF168 failed to affect the mRNA expression of RhoC and overexpression of RhoC rescued the inhibitory effects of RNF168 overexpression on the CSC‐like traits of NSCLC cells. Therefore, this study revealed RNF168 as a novel regulator of RhoC protein in NSCLC cells, this RNF168/RhoC regulatory axis might be a potential target for NSCLC treatment.
In Conversation with Fikile Nxumalo: Refiguring Onto-Epistemic Attunements for Im/possible Science Pedagogies
Authors: Nxumalo Fikile , Wallace Maria F. G. 
Published: December 2021

AbstractThis chapter elucidates critical concepts of place in relation to Black-feminist and more-than-human geographies in the context of early childhood education. This conversation helps get at pressing political contexts for science education that are often excluded in white educational spaces. Our conversation with Dr. Nxumalo offers practical starting points for researchers interested in playing with the messy intersections of materiality, settler-colonialism, white supremacy, Indigenous knowledges, and more-than-human kin.
The Emergence of Global Commodity Governance
Authors: Oehl Maximilian Eduard 
Published: December 2021

AbstractWhereas the challenges of GCG are manifold, its principal task lies in ensuring a functional commodity sector (Sect. 2.1). The ‘balanced’ mode through which it pursues this objective constitutes a departure from historical approaches to regulating transnational commodity activity (Sect. 2.2). The remainder of this treatise will be concerned with the role of the law in fostering the effectiveness of GCG (Sect. 2.3).
The Effectiveness of TCL
Authors: Oehl Maximilian Eduard 
Published: December 2021

AbstractThe challenge for TCL lies in balancing the five interests associated with commodity activity—control,participation,preservation,development, andeconomic gain. Whereas our account of the application of TCL within the commodity governance matrix above has demonstrated which of these objectives the individual norm subsets are seeking to fosterprimarily, the subsequent assessment will focus on the balancing quality of TCL. Where it strikes a balance, it can be deemed to be effective in ensuring a functional commodity sector.
Next-to-leading-order QCD corrections and parton-shower effects for weakino+squark production at the LHC
Authors: Baglio Julien , Coniglio Gabriele , Jäger Barbara , Spira Michael 
Published: December 2021

Abstract
We present a calculation of the next-to-leading order QCD corrections to weakino+squark production processes at hadron colliders and their implementation in the framework of the POWHEG-BOX, a tool for the matching of fixed-order perturbative calculations with parton-shower programs. Particular care is taken in the subtraction of on-shell resonances in the real-emission corrections that have to be assigned to production processes of a different type. In order to illustrate the capabilities of our code, representative results are shown for selected SUSY parameter points in the pMSSM11. The perturbative stability of the calculation is assessed for the pp →$$ {\tilde{\upchi}}_1^0{\tilde{d}}_L $$

χ
˜

1
0

d
˜

L

process. For the squark+chargino production process pp →$$ {\upchi}_1^{-}{\tilde{u}}_L $$

χ
1
−

u
˜

L

distributions of the chargino’s decay products are provided with the help of the decay feature of PYTHIA 8.
Electroweak skyrmions in the HEFT
Authors: Criado Juan Carlos , Khoze Valentin V. , Spannowsky Michael 
Published: December 2021

Abstract
We study the existence of skyrmions in the presence of all the electroweak degrees of freedom, including a dynamical Higgs boson, with the electroweak symmetry being non-linearly realized in the scalar sector. For this, we use the formulation of the Higgs Effective Field Theory (HEFT). In contrast with the linear realization, a well-defined winding number exists in HEFT for all scalar field configurations. We classify the effective operators that can potentially stabilize the skyrmions and numerically find the region in parameter spaces that support them. We do so by minimizing the static energy functional using neural networks. This method allows us to obtain the minimal-energy path connecting the vacuum to the skyrmion configuration and calculate its mass and radius. Since skyrmions are not expected to be produced at colliders, we explore the experimental and theoretical bounds on the operators that generate them. Finally, we briefly consider the possibility of skyrmions being dark matter candidates.
Second-Order PDEs in 3D with Einstein–Weyl Conformal Structure
Authors: Berjawi S. , Ferapontov E. V. , Kruglikov B. S. , Novikov V. S. 
Published: December 2021

AbstractEinstein–Weyl geometry is a triple $$({\mathbb {D}},g,\omega )$$

(
D
,
g
,
ω
)

where $${\mathbb {D}}$$
D
is a symmetric connection, [g] is a conformal structure and $$\omega $$
ω
is a covector such that $$\bullet $$
∙
connection $${\mathbb {D}}$$
D
preserves the conformal class [g], that is, $${\mathbb {D}}g=\omega g$$

D
g
=
ω
g

; $$\bullet $$
∙
trace-free part of the symmetrised Ricci tensor of $${\mathbb {D}}$$
D
vanishes. Three-dimensional Einstein–Weyl structures naturally arise on solutions of second-order dispersionless integrable PDEs in 3D. In this context, [g] coincides with the characteristic conformal structure and is therefore uniquely determined by the equation. On the contrary, covector $$\omega $$
ω
is a somewhat more mysterious object, recovered from the Einstein–Weyl conditions. We demonstrate that, for generic second-order PDEs (for instance, for all equations not of Monge–Ampère type), the covector $$\omega $$
ω
is also expressible in terms of the equation, thus providing an efficient ‘dispersionless integrability test’. The knowledge of g and $$\omega $$
ω
provides a dispersionless Lax pair by an explicit formula which is apparently new. Some partial classification results of PDEs with Einstein–Weyl characteristic conformal structure are obtained. A rigidity conjecture is proposed according to which for any generic second-order PDE with Einstein–Weyl property, all dependence on the 1-jet variables can be eliminated via a suitable contact transformation.
Change in Rhetoric but not in Action? Framing of the Ethical Issue of Modern Slavery in a UK Sector at High Risk of Labor Exploitation
Authors: Gutierrez-Huerter O Gabriela , Gold Stefan , Trautrims Alexander 
Published: December 2021

AbstractThis article shows how the ethical framing of the contemporary issue of modern slavery has evolved in UK construction, a sector in which there is a high risk of labor exploitation. It also examines how these framing dynamics have inhibited the emergence of a common framework of action to deal with the issue. We draw on both framing theory and the literature on the discursive construction of moral legitimacy. Our longitudinal analysis reveals that actors seeking to shape the debate bring their own moral schemes to justify and construct the legitimacy of their frames. Actors cluster their views around five evolving frames: human rights issue (later shifting to hidden crime), moral issue, management issue (later shifting to human moral obligation), social justice issue, and decent work issue—which promote particular normative evaluations of what the issue is, who is responsible, and recommendations for action. Our study contributes to a dynamic and political understanding of the meaning making of modern slavery. We identify the antecedents and conditions that have forestalled the emergence of new patterns of action to tackle modern slavery in the UK construction sector thereby evidencing the effects of the interplay of morally competing frames on field-level change.
Inverse parameter estimation to predict material parameters of the Cowper–Symonds constitutive equation in electrohydraulic forming process
Authors: Woo Mina , Kim Jeong 
Published: December 2021

AbstractThe development of a reliable numerical simulation is essential for understanding high-speed forming processes such as electrohydraulic forming (EHF). This numerical model should be created based on the accurate material properties. However, dynamic material properties at strain rates exceeding 1000 s$$^{-1}$$

-
1

cannot be easily obtained through an experimental approach. Thus, this study predicted two material parameters in the Cowper–Symonds constitutive equation based on inverse parameter estimation, such that the parameters predicted using the numerical simulation corresponded well with those obtained from the experimental results. The target material was a 1-mm-thick Al 5052-H32 sheet. The comparison target included the final deformation shape of the sheet in the EHF-free bulging test at three input voltages of 6, 7, and 8 kV. For the inverse parameter estimation, the posterior distribution for the two parameters included a likelihood and a prior distribution. For the likelihood construction, a reduced-order surrogate model was developed in advance to substitute the numerical simulation based on ordinary Kriging and principal component analysis. Moreover, the error distribution of the bulge height between the experiment and reduced-order surrogate model was obtained. The prior distribution at 7 kV was defined as a uniform distribution, and the posterior distribution at 7 kV was employed as a prior distribution at 6, 7, and 8 kV. Furthermore, Markov chain Monte Carlo sampling was employed and the Metropolis–Hastings algorithm was adopted to obtain the samples following the posterior distribution. After the autocorrelation calculation for sample independence, the lag with an autocorrelation of $$\pm \,0.02$$

±

0.02

interval was selected and every lag$$^{\mathrm {th}}$$

th

sample was obtained. The total number of acquired samples was $$10^{5}$$

10
5

, and the mean values were calculated from the obtained samples. Consequently, the numerical simulation with mean values displayed good agreement with the experimental results.
Ultrasonic agitation reduces the time of calcium hydroxide antimicrobial effect and enhances its penetrability
Authors: de Andrade Flaviana Bombarda , da Silva Munhoz Vasconcelos Layla Reginna , Pereira Thais Cristina , Garcia Roberto Brandão , Bramante Clóvis Monteiro , Duarte Marco Antônio Hungaro 
Published: December 2021

AbstractObjectives: The objective of the present work was to evaluate the ultrasonic agitation, time and vehicle (propylene glycol or distilled water) on the antimicrobial potential and penetrability of calcium hydroxide pastes on infected dentin by means of Confocal Laser Scanning Microscopy (CLSM) and microbiological culture (MC). Materials and methods: Dentin specimens were infected with Enterococcus faecalis using a new contamination protocol of 5 days. The specimens were divided into eight groups and dressed with the pastes for 7 or 15 days: G1) calcium hydroxide (CH) + propylene glycol (prop)/7 days (d), G2) CH + prop/7d + ultrasonic agitation (U), G3) CH + distilled water (dw)/7d, G4) CH + dw/7d + U, G5) CH + prop/15d, G6) CH + prop/15d + U, G7) CH + dw/15d, G8) CH + dw/15d + U. The ultrasonic activation was made for 1 min in both directions with a plain point insert. After medications removal, the images obtained by CLSM showed the viable (green) and dead (red) bacteria with Live and Dead dye. By the MC, the dentinal wall debris obtained by burs were collected for colony counts. For the penetration test, the Rodamine B dye was added to the CH pastes and analyzed by CLSM. Results: The 7 and 15-days CH + prop+U pastes performed better antimicrobial efficacy, followed by the CH + dw+U/15d paste. Conclusions: All pastes demonstrated better penetration and antimicrobial activity against E. faecalis when agitated with ultrasound, even in periods of up to seven days. The propylene glycol vehicle showed better results. Clinical relevance: Agitation of the dressing that remains for less time inside the root canal can optimize the decontamination of endodontic treatment.
Gambling Among Finnish 14–16-Year-Old Adolescents Before (2008–2009), During (2010–2011), and After (2013–2017) Setting the Legal Age Limit of 18 for Gambling and the Role of Socio-Economic Status
Authors: Latvala Tiina , Lintonen Tomi , Luopa Pauliina , Raisamo Susanna 
Published: December 2021

AbstractLegislation prohibiting minors from engaging in gambling is a gambling policy measure set to protect adolescents from the harmful effects of gambling. The Finnish gambling system is based on a state monopoly, regulated by the Lotteries Act. After an amendment to the Lotteries Act, the new minimum legal gambling age was raised to 18 years old between 2010 and 2011. The main purpose of this study was to discover how the amendment to the act altered adolescents’ gambling (14–16-year-olds) and to examine whether the amendment decreased socio-economic differences. Adolescents gambling was studied before (2008–2009), during (2010–2011), and after (2013–2017) the age limit of gambling was raised in Finland. The study based on five waves (2008–2009, 2010–2011, 2013, 2015, 2017) of the national repeated cross-sectional School Health Promotion Study. Cross-tabulations where gambling was studied by study year and socio-economic status (SES) were formulated, and the statistical differences were studied by using χ2-tests. Percentage change in gambling frequency was also examined by study year and SES. Study years were analyzed separately to model the weekly gambling via logistic regression models. Adolescent gambling significantly decreased over time. It appears that raising the legal gambling age had a permanent effect on under-aged gambling. However, differences in gambling by adolescents’ family’s SES increased during the study period, indicating widening inequalities in gambling among adolescents. Diminishing inequalities in adolescent gambling is likely to require both societal action and consensus on adolescent gambling being a significant social and public health concern.
Higher-Dimensional Stick Percolation
Authors: Broman Erik I. 
Published: December 2021

AbstractWe consider two cases of the so-called stick percolation model with sticks of length L. In the first case, the orientation is chosen independently and uniformly, while in the second all sticks are oriented along the same direction. We study their respective critical values $$\lambda _c(L)$$

λ
c

(
L
)

of the percolation phase transition, and in particular we investigate the asymptotic behavior of $$\lambda _c(L)$$

λ
c

(
L
)

as $$L\rightarrow \infty $$

L
→
∞

for both of these cases. In the first case we prove that $$\lambda _c(L)\sim L^{-2}$$

λ
c

(
L
)

∼

L

-
2

for any $$d\ge 2,$$

d
≥
2
,

while in the second we prove that $$\lambda _c(L)\sim L^{-1}$$

λ
c

(
L
)

∼

L

-
1

for any $$d\ge 2.$$

d
≥
2
.
Braided $$\varvec{L_{\infty }}$$-algebras, braided field theory and noncommutative gravity
Authors: Dimitrijević Ćirić Marija , Giotopoulos Grigorios , Radovanović Voja , Szabo Richard J. 
Published: December 2021

AbstractWe define a new homotopy algebraic structure, that we call a braided $$L_\infty $$

L
∞

-algebra, and use it to systematically construct a new class of noncommutative field theories, that we call braided field theories. Braided field theories have gauge symmetries which realize a braided Lie algebra, whose Noether identities are inhomogeneous extensions of the classical identities, and which do not act on the solutions of the field equations. We use Drinfel’d twist deformation quantization techniques to generate new noncommutative deformations of classical field theories with braided gauge symmetries, which we compare to the more conventional theories with star-gauge symmetries. We apply our formalism to introduce a braided version of general relativity without matter fields in the Einstein–Cartan–Palatini formalism. In the limit of vanishing deformation parameter, the braided theory of noncommutative gravity reduces to classical gravity without any extensions.
Integrability of the generalised Hill problem
Authors: Combot Thierry , Maciejewski Andrzej J. , Przybylska Maria 
Published: December 2021

AbstractWe consider a certain two-parameter generalisation of the planar Hill lunar problem. We prove that for nonzero values of these parameters the system is not integrable in the Liouville sense. For special choices of parameters the system coincides with the classical Hill system, the integrable synodical Kepler problem or the integrable parametric Hénon system. We prove that the synodical Kepler problem is not super-integrable, and that the parametric Hénon problem is super-integrable for infinitely many values of the parameter.
Utilization rate of the fleet: a novel performance metric for a novel shared mobility
Authors: González Ana Belén Rodríguez , Wilby Mark Richard , Díaz Juan José Vinagre , Pozo Rubén Fernández , Ávila Carmen Sánchez 
Published: December 2021

AbstractCar-sharing systems have irrupted in our cities following the shared mobility paradigm. They have evolved the personal mobility market from product-based into service-oriented, which ultimately provides a positive impact on the city’s sustainability. Car sharing systems are a complex interactive service, whose dynamics can dramatically affect its operational viability. In order to better asses this viability, we must rely on data to produce novel metrics that characterize both the user behavior and the service performance. Up to date, research has focused on modeling the demand on the basis of the number of rentals that start within a specific time slot. However, this approach seems unable to provide a representative metric of the performance of a car-sharing system. In this paper, we propose a novel metric, the utilization rate of the fleet, which considers the precise number of vehicles within a fleet that are in service every minute of the day. From this basic metric, we derive a key performance indicator (KPI) to reflect the viability of any car-sharing system in economic and sustainability terms. We have applied this new metric and KPI to a dataset with 449 days of car2go data, collected in 10 European cities.
Application of the Ultrafiltration and Photooxidation Process for the Treatment of Rainwater
Authors: Marszałek Anna , Dudziak Mariusz 
Published: December 2021

AbstractAs water resources become increasingly scarce, the concept of water reuse is gaining importance. Recently, attention has been paid to the use of rainwater as an alternative water resource. Part of this study, laboratory-scale experiments were conducted to evaluate the effectiveness and efficiency of the ultrafiltration process. The aim of the research was to assess the influence of pollutants from various roof coverings on the ultrafiltration process and the occurrence of membrane fouling. Additionally, the rainwater disinfection process was performed using UV radiation. Analysis of rainwater collected from various roofing materials, evaluating rainwater treatment by ultrafiltration in a cross-flow system, determination of the effectiveness and efficiency of the UF membrane, and additional disinfection of rainwater using UV radiation were carried out. Rainwater was collected from various roofing materials, such as steel roof tiles (RW1), bituminous shingles (RW2), and tar paper roofing (RW3). The treatment efficiency of ultrafiltration was evaluated by monitoring typical quality parameters: color, turbidity, COD, TOC, absorbance of UV254, ammonium, conductivity, and pH. Coliform bacteria, Escherichia coli and Enterococci, were monitored as total number of microorganisms at 22 ± 2 °C after 72 h. As expected, a significant reduction in individual parameters was recorded. COD of rainwater decreased in RW1 by 59%, in RW2 by 69%, and in RW3 by 74%. The ultrafiltration process ensured the complete retention of the coliform bacteria and E. coli. Complete elimination of microorganisms was demonstrated when the ultrafiltration process and UV radiation disinfection were combined.
Systemic liquidity contagion in the European interbank market
Authors: Macchiati Valentina , Brandi Giuseppe , Di Matteo Tiziana , Paolotti Daniela , Caldarelli Guido , Cimini Giulio 
Published: December 2021

AbstractSystemic liquidity risk, defined by the International Monetary Fund as “the risk of simultaneous liquidity difficulties at multiple financial institutions,” is a key topic in financial stability studies and macroprudential policy-making. In this context, the complex web of interconnections of the interbank market plays the crucial role of allowing funding liquidity shortages to propagate between financial institutions. Here, we introduce a simple yet effective model of the interbank market in which liquidity shortages propagate through an epidemic-like contagion mechanism on the network of interbank loans. The model is defined by using aggregate balance sheet information of European banks, and it exploits country and bank-specific risk features to account for the heterogeneity of financial institutions. Moreover, in order to obtain the European-wide topology of the interbank network, we define a block reconstruction method based on the exchange flows between the various countries. We show that the proposed contagion model is able to estimate systemic liquidity risk across different years and countries. Results suggest that our effective contagion approach can be successfully used as a viable alternative to more realistic but complicated models, which not only require more specific balance sheet variables with high time resolution but also need assumptions on how banks respond to liquidity shocks.