bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of clinical and radiographic signs of hip osteoarthritis in contralateral hip joints of fifty working dogs
Authors: Alves J. C. , Santos Ana , Jorge Patrícia , Lavrador Catarina , Carreira L. Miguel 
Published: March 2021

ObjectiveThis study aimed to compare the symmetry of clinical and radiographic signs of right and left pelvic limbs of dogs with bilateral hip osteoarthritis (OA) and evaluate the association of physical findings and radiographic abnormalities.Patients and methodsOne hundred pelvic limbs of police working dogs with bilateral hip OA were evaluated, following a screening program. Weight distribution, joint range of motion at flexion and extension, thigh girth, and radiographic signs were recorded and compared with the results of the contralateral limb and by breed, age, and sex with the Paired Samples T-Test and Pearson correlation coefficient, with p<0.05.ResultsThe sample mean age was 6.5±2.2 years, and the bodyweight of 26.7±5.3kg. No significant differences were observed when comparing weight distribution, joint range of motion, and thigh girth of left and right limbs. Weight distribution and age showed a statistically significant correlation with joint extension. The right limbs showed a significantly higher frequency of circumferential femoral head osteophyte (CFHO) regarding radiographic signs. Limbs with CFHO or caudolateral curvilinear osteophyte had significantly larger joint flexion angle (p = 0.02) and smaller extension angle (p<0.01), respectively, compared to those that did not. Age showed a significant correlation with the presence of several radiographic findings, as did different breeds.ConclusionClinical and radiographic signs occur symmetrically in naturally occurring hip OA in police working dogs. Several correlations were observed between the evaluations performed and differences between breeds, which can be useful in assessing and early diagnosis of hip OA.
Low-dose hydralazine during gestation reduces renal fibrosis in rodent offspring exposed to maternal high fat diet
Authors: Larkin Benjamin P. , Saad Sonia , Glastras Sarah J. , Nguyen Long T. , Hou Miao , Chen Hui , Wang Rosy , Pollock Carol A. 
Published: March 2021

Background
Maternal high fat diet (HFD) promotes chronic kidney disease (CKD) in offspring. This is in accordance with the theory of fetal programming, which suggests adverse conditions occurring in utero predispose offspring to chronic conditions later in life. DNA methylation has been proposed as a key mechanism by which fetal programming occurs and is implicated in CKD progression. DNA demethylating drugs may interrupt the fetal programming of CKD by maternal obesity. Hydralazine, an antihypertensive agent, demethylates DNA at low doses which do not reduce blood pressure. We used a mouse model of maternal obesity to determine whether gestational administration of low-dose hydralazine to mothers can prevent CKD in offspring.

Methods
C57BL/6 dams received HFD or chow from 6 weeks prior to mating and were administered subcutaneous hydralazine (5mg/kg) or saline thrice weekly during gestation. Male offspring were weaned to chow and were sacrificed at either postnatal week 9 or week 32. Biometric and metabolic parameters, renal global DNA methylation, renal structural and functional changes and markers of fibrosis, oxidative stress and inflammation were measured in offspring at weeks 9 and 32.

Results
In week 9 offspring, maternal HFD consumption did not significantly alter anthropometric or metabolic parameters, or renal global DNA methylation. Week 32 offspring had increased renal global DNA methylation, together with albuminuria, glomerulosclerosis, renal fibrosis and oxidative stress. Administration of low-dose hydralazine to obese mothers during gestation reduced renal global DNA methylation and renal fibrotic markers in week 32 offspring.

Conclusion
Gestational hydralazine reduced renal global DNA methylation in offspring of obese mothers and attenuated maternal obesity-induced renal fibrosis. These data support the use of low-dose hydralazine as a demethylating agent to prevent CKD arising in offspring due to maternal HFD consumption.
Do Children With Functional Abdominal Pain Benefit More From a Pain-Specific Cognitive-Behavioral Intervention Than From an Unspecific Attention Control Intervention? Results of a Randomized Controlled Trial
Authors: Warschburger Petra , Calvano Claudia , Becker Sebastian , Ebinger Friedrich , Hudert Christian , Iven Enno , Posovszky Carsten , Winter Sibylle-Maria , Daubmann Anne , Ozga Ann-Kathrin , Wegscheider Karl 
Published: March 2021

INTRODUCTION:
We aimed to compare the efficacy of cognitive-behavioral therapy (CBT) among children with functional abdominal pain with an attention control (AC), hypothesizing the superiority of CBT group intervention regarding pain intensity (primary outcome), pain duration and frequency (further primary outcomes), functional disability, and quality of life and coping strategies (key secondary outcomes).

METHODS:
We conducted a prospective, multicenter, randomized controlled efficacy trial (RCT) with 4 time points (before intervention, after intervention, 3-month follow-up, and 12-month follow-up). One hundred twenty-seven children aged 7–12 years were randomized to either the CBT (n = 63; 55.6% girls) or the AC (n = 64; 57.8% girls).

RESULTS:
Primary endpoint analysis of the logarithmized area under the pain intensity curve showed no significant difference between groups (mean reduction = 49.04%, 95% confidence interval [CI] −19.98%–78.36%). Treatment success rates were comparable (adjusted odds ratio = 0.53, 95% CI 0.21–1.34, number needed to treat = 16). However, time trend analyses over the course of 1 year revealed a significantly greater reduction in pain intensity (40.9%, 95% CI 2.7%–64.1%) and pain duration (43.6%, 95% CI 6.2%–66.1%) in the CBT compared with the AC, but not in pain frequency per day (1.2, 95% CI −2.7 to 5.2). In the long term, children in the CBT benefitted slightly more than those in the AC with respect to functional disability, quality of life, and coping strategies.

DISCUSSION:
Both interventions were effective, which underlines the role of time and attention for treatment efficacy. However, in the longer term, CBT yielded more favorable results.
Small Intestine Varices in Cirrhosis at a High-Volume Liver Transplant Center: A Retrospective Database Study and Literature Review
Authors: Jansson-Knodell Claire L. , Calderon Gerardo , Weber Regina , Ghabril Marwan 
Published: March 2021

INTRODUCTION:
Esophageal varices are a well-characterized sequela of portal hypertension; however, less is known about varices arising in ectopic locations. We aimed to describe bleeding small intestine varices (SIV) in patients with cirrhosis and compare characteristics and outcomes to published case reports.

METHODS:
We performed an institutional chart review using billing codes and natural language processing between 2008 and 2019. Inclusion criteria were adult patients with cirrhosis and SIV verified by endoscopy, video capsule, or imaging. Patients with noncirrhotic portal hypertension and stomal varices were excluded. We examined demographic and clinical factors, characteristics of SIV, bleeding, intervention, and outcomes in our series and collated data from published cases identified during a literature review.

RESULTS:
We identified 71 patients with cirrhosis and SIV (18 bled). The literature search yielded 76 cases with bleeding SIV. Our series and published cases were matched for age, sex, liver disease etiology, and SIV location. Length of stay and transfusion requirements were similar. Aggregate initial treatments (number, hemostasis rate) included medical (n = 7, 57%), endoscopic (n = 48, 56%), interventional radiology (n = 31, 77%), and surgery (n = 8, 87%). Hospital and overall mortality rates were higher in our series (22% and 38%) compared with the published cases (5.3% and 18.4%), respectively (P = 0.02 and P = 0.07).

DISCUSSION:
A quarter of patients with cirrhosis and SIV experience bleeding, with high transfusion requirements, frequent need for secondary interventions, and high mortality. These findings highlight the need for a multidisciplinary approach and second-line therapeutic modalities in the timely management of bleeding SIV in cirrhosis.
Prediction of Hepatocellular Carcinoma by On-Therapy Response of Noninvasive Fibrosis Markers in Chronic Hepatitis B
Authors: Nam Heechul , Lee Sung Won , Kwon Jung Hyun , Lee Hae Lim , Yoo Sun Hong , Kim Hee Yeon , Song Do Seon , Sung Pil Soo , Chang U Im , Kim Chang Wook , Nam Soon Woo , Bae Si Hyun , Choi Jong Young , Yoon Seung Kew , Yang Jin Mo , Han Nam Ik , Jang Jeong Won 
Published: March 2021

INTRODUCTION:
Antiviral therapy improves hepatic fibrosis and reduces hepatocellular carcinoma (HCC) incidence. This study aimed to evaluate whether on-therapy changes in scores for fibrosis index based on 4 factors and aspartate aminotransferase-to-platelet ratio index are associated with HCC development and establish an HCC risk score model incorporating noninvasive fibrosis marker (NFM) response.

METHODS:
This multicenter study recruited 5,147 patients with chronic hepatitis B (4,028 for derivation cohort and 1,119 for validation cohort) who were given entecavir/tenofovir for >12 months between 2007 and 2018. A risk prediction model for HCC was developed using predictors based on multivariable Cox models, and bootstrapping was performed for validation.

RESULTS:
The 10-year cumulative HCC incidence rates were 12.6% and 13.7% in the derivation and validation cohorts, respectively. The risk of HCC significantly differed with early NFM response, with a marked reduction in HCC risk in patients achieving a significant decrease in NFM by 12 months (P < 0.001). NFM response, sex, age, and cirrhosis were independently predictive of HCC. We developed the Fibrosis marker response, Sex, Age, and Cirrhosis (FSAC) score based on regression coefficients of each variable. For the 10-year prediction of HCC, FSAC showed higher C-index values than PAGE-B, modified PAGE-B, CU-HCC, and REACH-B (0.84 vs 0.77, 0.80, 0.77, and 0.67, respectively; all P < 0.005). The predictive performance of FSAC was corroborated in the validation cohort, with higher C-index than other models (all P < 0.050).

DISCUSSION:
On-therapy changes in NFM are an independent indicator of HCC risk. FSAC incorporating NFM response is a reliable risk score for risk estimation for HCC with better performance than other models.
Not that simple goiter
Authors: Gerasimov Gregory A. 
Published: March 2021

The year 2020 marks the centenary of the publication of a classic study by American physicians D. Marine and O. Kimball on the effectiveness of endemic goiter prevention in children in Akron, Ohio. Although goiter has been known from immemorial times, there is still a problem with determining the normal size of the thyroid gland, without which the diagnosis of goiter remains extremely subjective. For example, in Sweden over the past 20 years, not a single case of endemic goiter has been registered, which is not surprising: the country eliminated this pathology decades ago, and the median urinary iodine concentration indicates the optimal iodine intake. Cases of sporadic goiter in children in Sweden are also rare — no more than 6–8 per year. But in Belarus, with the same population (about 10 million), about 2900 cases of goiter in children, both endemic and sporadic, are recorded annually despite the fact that, due to the extensive use of iodized salt since the beginning of the 2000s, there is no iodine deficiency. The incidence of goiter in children, however, having decreased many times over the past 20 years, remains 3 times higher than in Russia, where iodine prophylaxis, if carried out on a limited scale. From the experience of Belarus, Sweden and Russia, we see that the main thing when assessing data on the incidence of goiter and other thyroid diseases associated with iodine deficiency should be not absolute numbers, but the trend of these indicators over the past years. This information should be more actively used by endocrinologists in Russia to assess the effectiveness of preventive measures both at the regional and federal levels.
Endogenous and exogenous interferences in thyroid function immunoassays
Authors: Kim Ekaterina I. , Dimitrova Diana А. , Dimitrova Diana A. , Katamadze Nino N. , Dzantieva Tamara S. 
Published: March 2021

Laboratory diagnosis of endocrine diseases has undergone many important changes over the past decades, despite the progress of thyroid function immunoassays technologies interferences cannot be completely excluded. These interferences can affect measurement of analyte which leads to misinterpretation and subsequent wrong clinical decisions, the probability of which is about 1%. However, the scale of the problem may be greater due to the lack of awareness to the problem among doctors and the lack of laboratory screening for interfering factors. These factors can be both endogenous and exogenous, bind both to antibodies to the analyte and to the reagent in the test system. The specificity of the immunoassay depends not only on the binding properties of antibodies, the activity of reagent, but also on the composition of the test system and the format of the methodology (non-competitive two-site or “sandwich” and competitive assays).
This review provides a description of the main interferences that can affect the measurement of thyroid hormones, in particular thyroid stimulating hormone, free thyroxine and triiodothyronine, calcitonin, and demonstrates clinical cases reported in the literature over the past few years.
POLA ASUH ANAK DI TENGAH PANDEMI COVID-19: Pendekatan Humanistik dalam mendukung Tumbuh Kembang Anak
Authors: Effendi Yusuf 
Published: March 2021

The COVID-19 pandemi has made all children's activities ranging from teaching and learning activities to self-development to be carried out at home. Parents are required to be able to guide and facilitate all their children's needs to ensure that children can learn and develop well. For that we need a good parenting style and support the child's self development. The purpose of this study is to find a complete integration of parenting patterns based on Abraham Maslow's humanistic concept to ensure the fulfillment of children's needs amid the COVID-19 pandemi while ensuring that children develop well. This study uses a qualitative research method with a literature approach to collect, study and analyze a complete concept of parenting in the midst of a pandemic. This research found that the integration of humanistic concepts in parenting in the midst of the COVID-19 pandemi resulted in a holistic parenting concept by paying attention to several aspects such as the fulfillment of physiological needs, security, love and affection, self-esteem and culminating in self-actualization where children are capable. understand and develop self potential well. Keyword : COVID-19, Pandemi, Parenting, Humanistic Psychology
Effect of adding rare-earth cerium on the microstructure and acid rain corrosion resistance of the ADC12 alloy
Authors: Zhang LiJie , Yan Hong , Zou YongCheng , Yu BaoBiao , Hu Zhi 
Published: March 2021

Abstract
The effect of adding cerium on the microstructure and acid rain corrosion resistance of the AlSi11Cu3 alloy was investigated by means of optical microscopy, scanning electron microscopy, and energy dispersive spectroscopy. The AlSi11Cu3 alloy was doped with varying stoichiometries of cerium to generate AlSi11Cu3-xCe, where x = 0, 0.5, 1.0, and 1.5 wt.%. The results show that the α-Al, eutectic Si, and β-Al5FeSi phases in the AlSi11Cu3-1.0Ce alloy are significantly refined. Electrochemical tests demonstrated an increase in the self-corrosion potential value of the AlSi11Cu3-1.0Ce alloy from –670 mV to –628 mV relative to the untreated alloy. In addition, the AlSi11Cu3-1.0Ce alloy has the lowest corrosion current density (8.4 μA × cm–2). Immersion corrosion testing on the AlSi11Cu3-1.0Ce alloy revealed a corrosion rate of 0.71 mg × cm–2 × d–1, constituting a 72% reduction in the corrosion rate compared to the untreated alloy. These results indicate that the AlSi11Cu3-1.0Ce alloy has a high resistance to acid rain corrosion, which is the result of a refinement of the cathode phases.
Effect of TiO2 crystal form on the denitration performance of Ce–W–Ti catalyst
Authors: Bian Xue , Yu Yuntao , Hao Nana , Wu Wenyuan 
Published: March 2021

Abstract
Titanium dioxide supports, which were prepared by roasting metatitanic acid under different conditions, were used to prepare a series of Ce–W–Ti catalysts. The structure and denitration properties of the catalyst were studied. The results showed that TiO2 had different crystal types (mixed crystal phases with different proportions of anatase and rutile) under different roasting conditions, and the denitration efficiency of mixed crystal was better than that of pure phase TiO2. Ce–W/200 °C-1 hTiO2 catalyst exhibited a prominent NO conversion rate, and it can reach higher than 90% at a temperature range from 250 to 500°C. The large specific surface area, low content of rutile TiO2 in the support, high content of chemical adsorbed oxygen and high surface acidity were favorable to denitration performance of Ce–W–Ti catalyst.
Comparison of simulation observer tools on engagement and maximising learning: a pilot study
Authors: Johnston Sandra , Tutticci Naomi , Theobald Karen , Ramsbotham Joanne 
Published: March 2021

Abstract

Objectives
This pilot study examined if the Clinical Reasoning Observer Worksheet (CROW) compared to a standard observer worksheet used during simulation, would enhance nursing students active learning behaviours and perceptions of clinical reasoning ability.

Methods
This pilot study was undertaken to test the design and processes for a future larger study and reports on preliminary evidence of efficacy of recruitment procedures and instrumentation in addition to student’s learning outcomes.

Results
There was little overall difference in outcomes between groups who used either simulation observer worksheet. Overall, participants who used either worksheet perceived their ability to apply clinical reasoning to an episode of patient care increased.

Conclusions
Modifications were identified as necessary for a larger study including changes to instrumentation, method of survey delivery and training of simulation facilitators. A more definitive evaluation will be achievable with a larger group of students in a main study with the suggested modifications.
OverCOVID: an integrative web portal for SARS-CoV-2 bioinformatics resources
Authors: Ahsan Md. Asif , Liu Yongjing , Feng Cong , Hofestädt Ralf , Chen Ming 
Published: March 2021

Abstract
Outbreaks of COVID-19 caused by the novel coronavirus SARS-CoV-2 is still a threat to global human health. In order to understand the biology of SARS-CoV-2 and developing drug against COVID-19, a vast amount of genomic, proteomic, interatomic, and clinical data is being generated, and the bioinformatics researchers produced databases, webservers and tools to gather those publicly available data and provide an opportunity of analyzing such data. However, these bioinformatics resources are scattered and researchers need to find them from different resources discretely. To facilitate researchers in finding the resources in one frame, we have developed an integrated web portal called OverCOVID (http://bis.zju.edu.cn/overcovid/). The publicly available webservers, databases and tools associated with SARS-CoV-2 have been incorporated in the resource page. In addition, a network view of the resources is provided to display the scope of the research. Other information like SARS-CoV-2 strains is visualized and various layers of interaction resources is listed in distinct pages of the web portal. As an integrative web portal, the OverCOVID will help the scientist to search the resources and accelerate the clinical research of SARS-CoV-2.
How words make the world: language materialities and the circulation of the Sakha algys
Authors: Ferguson Jenanne 
Published: March 2021

Abstract
This article investigates contemporary uses of the Sakha language algys (blessing poems) and reveals the “old” and “new” types of language materiality present in this genre of ritual poetry. Focusing primarily on one example of algys shared online in 2018, I discuss how performing algys has always involved close interconnection between language and the material world and present the changing contexts and forms of algys transmission that highlight both fixity and fluidity in the way speakers conceive of language and materiality. Despite the new mobilities and technologies that build upon the previously established written textual forms of this poetry—and contribute to its continued circulation and transmission—certain elements of traditional algys remains salient for speakers, reinforced by ideologies or ontologies of language that foreground the power of the (spoken) word. This is connected to the production of qualia and the invocation of chronotopes. Thus, while textual forms further enable processes of citationality as they are circulated online; the written words alone do not constitute an algys. Rather, here the importance of embodied, spoken language materiality is at the fore.
The crystal structure of 2-amino-5-nitroanilinium iodide monohydrate, C6H8IN3O2
Authors: Du Chao-Jun , Niu De-Long , Zheng Shi-Li , Zeng Yan 
Published: March 2021

Abstract
C6H8IN3O2, monoclinic, P21/n (no. 14), a = 7.0704(3) Å, b = 15.7781(6) Å, c = 9.1495(4) Å, β = 112.114(1)°, V = 945.61(7) Å3, Z = 4, R

gt
(F) = 0.0187, wR

ref
(F
2) = 0.0522, T = 150(2) K.
Perceived Neighborhood Walkability is Associated with Recent Falls in Urban Dwelling Older Adults
Authors: Blackwood Jennifer , Suzuki Rie , Karczewski Hannah 
Published: March 2021

Background and Purpose:
In rural communities, perceptions of neighborhood walkability, the rating of how easy it is to walk in an area, influence engagement in physical activity outside the home. This has not been studied in older adults residing in urban settings. Additionally, it is not known how perceived walkability is associated with falls. Therefore, the purpose of this study was to first describe the perceptions of neighborhood walkability in urban-dwelling older adults based on recent fall history and then examine associations between recent falls and neighborhood walkability constructs after controlling for fall risk factors.

Methods:
Urban-dwelling older adults (N = 132) 65 years and older without cognitive dysfunction or uncontrolled comorbidity completed a survey assessing health status, physical activity, and walkability using the Neighborhood Environment Walkability Scale-Abbreviated. Group assignment was based on recent fall history. Between-group comparisons of demographic and walkability constructs were completed using analysis of variance. Logistic regression was used to examine associations between walkability constructs and recent falls after controlling for covariates.

Results and Discussion:
Poorer perception of land use was significantly associated with recent falls. Questions assessing the ease of walking to a store or transit stop may be valuable in understanding fall risk in older adults living in urban settings.

Conclusions:
Perceptions of neighborhood walkability are lower in urban-dwelling older adults with a history of falling.