bluuebunny/crossref_metadata_2025_split huggingface dataset:
HDFN Resulting from Anti-U: Alternatives to Allogeneic Intrauterine Transfusion
Authors: Caudill Jamie L , Gillard Laurie 
Published: October 2021

Abstract
Hemolytic disease of the fetus and newborn (HDFN) carries significant fetal mortality risks. Although anti-D as a source of HDFN has been prevented for decades using D-specific immunoglobulin to prevent alloimmunization between fetus and mother, minor blood groups may still result in disease, with potentially disastrous consequences if left untreated. Strategies such as intrauterine transfusion, early delivery, and vigilant serologic monitoring of fetal anemia have been the standards of care for alloimmunized patients, but beyond this not much more is possible. Mothers with rare phenotypes who are alloimmunized against extremely common red blood cell antigens may find access to rare antigen-negative blood units limited. This case study presents a healthy G10P6 woman with known anti-U presenting for treatment via intrauterine transfusion in the second trimester and follows the patient through successful delivery. Difficulties in obtaining rare blood for the patient because of concomitant delivery events involving 2 patients with anti-U at the facility opened discussions about the difficulties of and alternatives to intrauterine transfusion where rare blood phenotypes are involved.
Precision in high resolution absorption line modelling, analytic Voigt derivatives, and optimization methods
Authors: Webb John K , Carswell Robert F , Lee Chung-Chi 
Published: October 2021

ABSTRACT
This paper describes the optimization theory on which vpfit, a non-linear least-squares program for modelling absorption spectra, is based. Particular attention is paid to precision. Voigt function derivatives have previously been calculated using numerical finite difference approximations. We show how these can instead be computed analytically using Taylor series expansions and look-up tables. We introduce a new optimization method for an efficient descent path to the best fit, combining the principles used in both the Gauss–Newton and Levenberg–Marquardt algorithms. A simple practical fix for ill-conditioning is described, a common problem when modelling quasar absorption systems. We also summarize how unbiased modelling depends on using an appropriate information criterion to guard against overfitting or underfitting. The methods and the new implementations introduced in this paper are aimed at optimal usage of future data from facilities such as ESPRESSO/VLT and HIRES/ELT, particularly for the most demanding applications such as searches for space–time variations in fundamental constants and attempts to detect cosmological redshift drift.
Velocity-imaging the rapidly precessing planetary disc around the white dwarf HE 1349–2305 using Doppler tomography
Authors: Manser Christopher J , Dennihy Erik , Gänsicke Boris T , Debes John H , Gentile Fusillo Nicola P , Hermes J J , Hollands Mark , Izquierdo Paula , Kaiser B C , Marsh T R , Reding Joshua S , Rodríguez-Gil Pablo , Veras Dimitri , Wilson David J 
Published: October 2021

ABSTRACT
The presence of planetary material in white dwarf atmospheres, thought to be accreted from a dusty debris disc produced via the tidal disruption of a planetesimal, is common. Approximately 5 per cent of these discs host a co-orbital gaseous component detectable via emission from atomic transitions  –  usually the 8600 Å Ca ii triplet. These emission profiles can be highly variable in both morphology and strength. Furthermore, the morphological variations in a few systems have been shown to be periodic, likely produced by an apsidally precessing asymmetric disc. Of the known gaseous debris discs, that around HE 1349–2305 has the most rapidly evolving emission-line morphology, and we present updated spectroscopy of the Ca ii triplet of this system. The additional observations show that the emission-line morphologies vary periodically and consistently, and we constrain the period to two aliases of 459 ± 3 and 502 ± 3 d. We produce images of the Ca ii triplet emission from the disc in velocity space using Doppler tomography  –  only the second such imaging of a white dwarf debris disc. We suggest that the asymmetric nature of these velocity images is generated by gas moving on eccentric orbits with radially dependent excitation conditions via photoionization from the white dwarf. We also obtained short-cadence (≃4 min) spectroscopy to search for variability on the time-scale of the disc’s orbital period (≃hours) due to the presence of a planetesimal, and rule out variability at a level of ≃1.4 per cent.
On measuring the Hubble constant with X-ray reverberation mapping of active galactic nuclei
Authors: Ingram Adam , Mastroserio Guglielmo , van der Klis Michiel , Nathan Edward , Connors Riley , Dauser Thomas , García Javier A , Kara Erin , König Ole , Lucchini Matteo , Wang Jingyi 
Published: October 2021

ABSTRACT
We show that X-ray reverberation mapping can be used to measure the distance to type 1 active galactic nuclei (AGNs). This is because X-ray photons originally emitted from the ‘corona’ close to the black hole irradiate the accretion disc and are reemitted with a characteristic ‘reflection’ spectrum that includes a prominent ∼6.4 keV iron emission line. The shape of the reflection spectrum depends on the irradiating flux, and the light-crossing delay between continuum photons observed directly from the corona and the reflected photons constrain the size of the disc. Simultaneously modelling the X-ray spectrum and the time delays between photons of different energies therefore constrains the intrinsic reflected luminosity, and the distance follows from the observed reflected flux. Alternatively, the distance can be measured from the X-ray spectrum alone if the black hole mass is known. We develop a new model of our reltrans X-ray reverberation mapping package, called rtdist, that has distance as a model parameter. We simulate a synthetic observation that we fit with our new model, and find that this technique applied to a sample of ∼25 AGNs can be used to measure the Hubble constant with a 3σ statistical uncertainty of ${\sim} 6\,{\rm km}\,{\rm s}^{-1}\, {\rm Mpc}^{-1}$. Since the technique is completely independent of the traditional distance ladder and the cosmic microwave background radiation, it has the potential to address the current tension between them. We discuss sources of modelling uncertainty, and how they can be addressed in the near future.
Effect of TNF inhibitors with bisphosphonates vs bisphosphonates alone on bone mineral density and bone and cartilage biomarkers at 1 year in patients with rheumatoid arthritis: A prospective study
Authors: Nagase Yuichi , Nagashima Masakazu , Shimane Kenichi , Nishikawa Takuji , Naito Masashi , Tanaka Sakae 
Published: October 2021

ABSTRACT

Background
The present study aimed prospectively to investigate the effect of a combination of tumour necrosis factor inhibitors and bisphosphonates (TNFi with BP) on bone mineral density (BMD) and bone and cartilage biomarkers compared to that of BP alone at 1 year in patients with rheumatoid arthritis (RA).

Methods
Two groups of patients with RA and osteoporosis were enrolled. One group (37 patients) had already received BP, while the other group (37 patients) had already received TNFi with BP. The serum bone resorption and formation markers, cartilage markers, BMD in the lumbar spine, femoral neck, and distal radius were prospectively investigated at the beginning of the study and at 6 and 12 months.

Results
The percentages of change recorded for the various assessment categories were as follows in the TNFi with BP group: (1) tartrate-resistant acid phosphatase-5b had significantly decreased and osteocalcin had increased; (2) matrix metalloproteinase-3 and cartilage oligomeric matrix protein had significantly decreased; and (3) each BMD did not differ significantly between the groups.

Conclusion
Our data suggested that TNFi with BP therapy not only suppressed cartilage degradation and bone resorption but also increased bone formation; however, this treatment did not affect the BMD at 1 year.
Complexity of enthesitis and new bone formation in ankylosing spondylitis: current understanding of the immunopathology and therapeutic approaches
Authors: Kusuda Masaki , Haroon Nigil , Nakamura Akihiro 
Published: October 2021

ABSTRACTDespite increasing availability of treatments for spondyloarthritis (SpA) including tumour necrosis factor (TNF) and interleukin-17 (IL-17) inhibitors, there is no established treatment that abates new bone formation (NBF) in ankylosing spondylitis (AS), a subset of SpA. Recent research on TNF has revealed the increased level of transmembrane TNF in the joint tissue of SpA patients compared to that of rheumatoid arthritis patients, which appears to facilitate TNF-driven osteo-proliferative changes in AS. In addition, there is considerable interest in the central role of IL-23/IL-17 axis in type 3 immunity and the therapeutic potential of blocking this axis to ameliorate enthesitis and NBF in AS. AS immunopathology involves a variety of immune cells, including both innate and adoptive immune cells, to orchestrate the immune response driving type 3 immunity. In response to external stimuli of inflammatory cytokines, local osteo-chondral progenitor cells activate intra-cellular anabolic molecules and signals involving hedgehog, bone morphogenetic proteins, receptor activator of nuclear factor kappa-B ligand, and Wnt pathways to promote NBF in AS. Here, we provide an overview of the current immunopathology and future directions for the treatment of enthesitis and NBF associated with AS.
Fast interaction dynamics of G-quadruplex and RGG-rich peptides unveiled in zero-mode waveguides
Authors: Patra Satyajit , Claude Jean-Benoît , Naubron Jean-Valère , Wenger Jérome 
Published: October 2021

Abstract
G-quadruplexes (GQs), a non-canonical form of DNA, are receiving a huge interest as target sites for potential applications in antiviral and anticancer drug treatments. The biological functions of GQs can be controlled by specifically binding proteins known as GQs binding proteins. Some of the GQs binding proteins contain an arginine and glycine-rich sequence known as RGG peptide. Despite the important role of RGG, the GQs-RGG interaction remains poorly understood. By single molecule measurements, the interaction dynamics can be determined in principle. However, the RGG–GQs interaction occurs at micromolar concentrations, making conventional single-molecule experiments impossible with a diffraction-limited confocal microscope. Here, we use a 120 nm zero-mode waveguide (ZMW) nanoaperture to overcome the diffraction limit. The combination of dual-color fluorescence cross-correlation spectroscopy (FCCS) with FRET is used to unveil the interaction dynamics and measure the association and dissociation rates. Our data show that the RGG–GQs interaction is predominantly driven by electrostatics but that a specific affinity between the RGG sequence and the GQs structure is preserved. The single molecule approach at micromolar concentration is the key to improve our understanding of GQs function and develop its therapeutic applications by screening a large library of GQs-targeting peptides and proteins.
DNA sequence and methylation prescribe the inside-out conformational dynamics and bending energetics of DNA minicircles
Authors: Yoo Jejoong , Park Sangwoo , Maffeo Christopher , Ha Taekjip , Aksimentiev Aleksei 
Published: October 2021

Abstract
Eukaryotic genome and methylome encode DNA fragments’ propensity to form nucleosome particles. Although the mechanical properties of DNA possibly orchestrate such encoding, the definite link between ‘omics’ and DNA energetics has remained elusive. Here, we bridge the divide by examining the sequence-dependent energetics of highly bent DNA. Molecular dynamics simulations of 42 intact DNA minicircles reveal that each DNA minicircle undergoes inside-out conformational transitions with the most likely configuration uniquely prescribed by the nucleotide sequence and methylation of DNA. The minicircles’ local geometry consists of straight segments connected by sharp bends compressing the DNA’s inward-facing major groove. Such an uneven distribution of the bending stress favors minimum free energy configurations that avoid stiff base pair sequences at inward-facing major grooves. Analysis of the minicircles’ inside-out free energy landscapes yields a discrete worm-like chain model of bent DNA energetics that accurately account for its nucleotide sequence and methylation. Experimentally measuring the dependence of the DNA looping time on the DNA sequence validates the model. When applied to a nucleosome-like DNA configuration, the model quantitatively reproduces yeast and human genomes’ nucleosome occupancy. Further analyses of the genome-wide chromatin structure data suggest that DNA bending energetics is a fundamental determinant of genome architecture.
Integration of single cell data by disentangled representation learning
Authors: Guo Tiantian , Chen Yang , Shi Minglei , Li Xiangyu , Zhang Michael Q 
Published: October 2021

Abstract
Recent developments of single cell RNA-sequencing technologies lead to the exponential growth of single cell sequencing datasets across different conditions. Combining these datasets helps to better understand cellular identity and function. However, it is challenging to integrate different datasets from different laboratories or technologies due to batch effect, which are interspersed with biological variances. To overcome this problem, we have proposed Single Cell Integration by Disentangled Representation Learning (SCIDRL), a domain adaption-based method, to learn low-dimensional representations invariant to batch effect. This method can efficiently remove batch effect while retaining cell type purity. We applied it to thirteen diverse simulated and real datasets. Benchmark results show that SCIDRL outperforms other methods in most cases and exhibits excellent performances in two common situations: (i) effective integration of batch-shared rare cell types and preservation of batch-specific rare cell types; (ii) reliable integration of datasets with different cell compositions. This demonstrates SCIDRL will offer a valuable tool for researchers to decode the enigma of cell heterogeneity.
Robotic-Assisted Trajectory Into Kambin's Triangle During Percutaneous Transforaminal Lumbar Interbody Fusion—Initial Case Series Investigating Safety and Efficacy
Authors: Dalton Tara , Sykes David , Wang Timothy Y , Donnelly Dustin , Than Khoi D , Karikari Isaac O , Goodwin C Rory , Gupta Dhanesh K , Wiggins Walter F , Abd-El-Barr Muhammad M 
Published: October 2021

Abstract

BACKGROUND
Minimally invasive spine surgery (MISS) has the potential to further advance with the use of robot-assisted (RA) techniques. While RA pedicle screw placement has been extensively investigated, there is a lack of literature on the use of the robot for other tasks, such as accessing Kambin's triangle in percutaneous lumbar interbody fusion (percLIF).

OBJECTIVE
To characterize the surgical feasibility and preliminary outcomes of an initial case series of 10 patients receiving percLIF with RA cage placement via Kambin's triangle.

METHODS
We performed a single-center, retrospective review of patients undergoing RA percLIF using robot-guided trajectory to access Kambin's triangle for cage placement. Patients undergoing RA percLIF were eligible for enrollment. Baseline health and demographic information in addition to peri- and postoperative data was collected. The dimensions of each patient's Kambin's triangle were measured.

RESULTS
Ten patients and 11 levels with spondylolisthesis were retrospectively reviewed. All patients successfully underwent the planned procedure without perioperative complications. Four patients underwent their procedure with awake anesthesia. The average dimension of Kambin's triangle was 66.3 m2. With the exception of 1 patient who stayed in the hospital for 7 d, the average length of stay was 1.2 d, with 2 patients discharged the day of surgery. No patients suffered postoperative motor or sensory deficits. Spinopelvic parameters and anterior and posterior disc heights were improved with surgery.

CONCLUSION
As MISS continues to evolve, further exploration of robot-guided surgical practice, such as our technique, will lead to creative solutions to challenging anatomical variation and overall improved patient care.
Influence of global environmental Change on plankton
Authors: Raven John A , Beardall John 
Published: October 2021

AbstractMuch has been published on the effects of ocean acidification on plankton since the original Royal Society 2005 report. In addition to direct effects on primary production, it is clear that ocean acidification also has profound consequences for biogeochemistry. Furthermore, although ocean acidification can have direct effects of on grazers such as copepods, acidification induces changes in nutritional value of phytoplankton which can be passed on up the food chain. There has also been recognition of the complexity of the interactions between elevated CO2 and other environmental factors and this has seen an upsurge in climate change research involving multifactorial experiments. In particular, the interaction of ocean acidification with global warming resulting from the increasing greenhouse effect has been investigated. There has also been research on acidification and warming effects in inland water plankton. These, combined with novel experimental techniques and long term studies of genetic adaptation, are providing better insights to plankton biology and communities in a future world.
Tapering of TNF inhibitors in axial spondyloarthritis in routine care — 2-year clinical and MRI outcomes and predictors of successful tapering
Authors: Wetterslev Marie , Georgiadis Stylianos , Sørensen Inge Juul , Pedersen Susanne Juhl , Christiansen Sara Nysom , Hetland Merete Lund , Brahe Cecilie Heegaard , Bakkegaard Mads , Duer Anne , Boesen Mikael , Gosvig Kasper Kjærulf , Møller Jakob Møllenbach , Krogh Niels Steen , Jensen Bente , Madsen Ole Rintek , Christensen Jan , Hansen Annette , Nørregaard Jesper , Røgind Henrik , Østergaard Mikkel 
Published: October 2021

Abstract

Objectives
In a 2-year follow-up study of patients with axial spondyloarthritis (axSpA) in clinical remission who tapered TNF inhibitor (TNFi) treatment according to a clinical guideline, we aimed to investigate the proportion who successfully tapered/discontinued therapy and baseline predictors thereof. The proportion regaining clinical remission after flare and the progression on MRI/radiography were also assessed.

Methods
One-hundred-and-nine patients (78 [72%]/31 [28%] receiving standard and reduced dose, respectively) in clinical remission (BASDAI &lt; 40, physician global score &lt; 40) and no signs of disease activity the previous year tapered TNFi as follows: to two-thirds of standard dose at baseline, half at week 16, one-third at week 32 and discontinuation at week 48. Patients experiencing clinical, BASDAI or MRI flare (predefined criteria) stopped tapering and escalated to previous dose. Prediction analyses were performed by multivariable regression.

Results
One hundred and six patients (97%) completed 2 years’ follow-up; 55 patients (52%) had successfully tapered: 23 (22%) receiving two-thirds, 15 (14%) half, 16 (15%) one-third dose and 1 (1%) discontinued. In patients at standard dose at baseline (n = 78), lower physician global score was the only independent predictor of successful tapering (odds ratio [OR] = 0.79 [95% CI: 0.64, 0.93]; P = 0.003). In the entire patient group lower physician global score (OR = 0.86 [0.75, 0.98]; P = 0.017), lower Spondyloarthritis Research Consortium of Canada (SPARCC) Sacroiliac Joint Erosion score (OR = 0.78 [0.57, 0.98]; P = 0.029) and current smoker (OR = 3.28 [1.15, 10.57]; P = 0.026) were independent predictors of successful tapering. At 2 years, 97% of patients were in clinical remission. Minimal changes in imaging findings were observed.

Conclusion
After 2 years following a clinical guideline, 52% of patients with axSpA in clinical remission had successfully tapered TNFi, only 1% discontinued. Baseline physician global score was an independent predictor of successful tapering.
Asian in the Time of COVID-19: Creating a Social Work Agenda for Asian American and Pacific Islander Communities
Authors: Azhar Sameena , Farina Anne , Alvarez Antonia R. G. , Klumpner Susan 
Published: October 2021

Abstract
The health of Asian American and Pacific Islander (AAPI) communities remains an understudied area of racial/ethnic minority research in the United States, and even more so in the field of social work. The COVID-19 pandemic has highlighted how AAPI health and social welfare issues have not received adequate attention in social policy, social work practice, and research. Contrary to model minority myths, AAPIs are subject to racialized attitudes and discrimination, which have been associated with adverse physical and mental health outcomes, including increased anxiety, depression, and suicidality. Drawing from the theoretical framework of AsianCrit, which is grounded in critical race theory, authors analyze health disparities among AAPI communities as reflected in COVID-19 hospitalizations and fatalities, as well as increases in acts of anti-Asian racism and xenophobia. Better understanding health disparities of AAPI communities needs to be a key research issue for social workers in future years. The authors conclude by offering a short set of recommendations to improve social policy, social work practice, and research to more aptly address contemporary social issues impacting AAPI communities.
Understanding COVID-19 through a Complex Trauma Lens: Implications for Effective Psychosocial Responses
Authors: Alessi Edward J , Hutchison Courtney , Kahn Sarilee 
Published: October 2021

Abstract
The psychosocial impact of COVID-19 on individuals, families, and communities will likely persist for years to come. While briefing notes informed by disaster psychology and crisis management have been released to guide social workers and other mental health professionals in their work during the pandemic, the far-reaching impacts of COVID-19 may require inclusion of additional theories of trauma and resilience. Thus, this article first examines the application of complex trauma theory as an effective framework for assessing the psychosocial impacts of the pandemic, especially among individuals with prior trauma exposure, those with preexisting mental illness, and communities affected by marginalization and historical trauma. Authors then discuss the importance of using trauma-informed practice to address the effects of the pandemic on both individual and community levels during this unprecedented moment in history.