bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metronomic Capecitabine Plus Aromatase Inhibitor as Initial Therapy in Patients With Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer—The Phase III MECCA Trial
Authors: Hong Ruo-Xi , Xu Fei , Xia Wen , Teng Yue-E , Ouyang Qu-Chang , Zheng Qiu-Fan , Yuan Zhong-Yu , Chen Dong-Shao , Jiang Kui-Kui , Lin Ying , Dai Zhen , Liu Xin-Lan , Chen Qian-Jun , Wu Xin-Hong , Shi Yan-Xia , Huang Jia-Jia , An Xin , Xue Cong , Bi Xi-Wen , Chen Mei-Ting , Li Hui , Yao He-Rui , Zou Guo-Rong , Huang Heng , Zhang Jing-Min , Wang Shu-Sen 
Published: January 2025

PURPOSE
The effects of metronomic chemotherapy plus endocrine therapy have yet to be elucidated through a randomized phase III clinical trial.

METHODS
Randomized clinical trials were conducted at 12 centers in China from August 22, 2017, to September 24, 2021, and the final follow-up date was August 25, 2023. Patients with hormone receptor–positive, human epidermal growth factor receptor 2 (HER2)–negative metastatic breast cancer (MBC) who had no previous systemic therapy in the metastatic setting were enrolled. Participants were 1:1 assigned to receive either metronomic capecitabine plus an aromatase inhibitor (AI) or AI alone. The primary end point was progression-free survival (PFS). Secondary end points included overall survival (OS), objective response rate, disease control rate (defined as disease controlled for ≥24 weeks), and safety.

RESULTS
A total of 263 patients were randomly assigned, among which 254 patients formed the full analysis set. At the median follow-up time of 50.7 months, 203 PFS events occurred. The metronomic capecitabine plus AI arm exhibited a median PFS of 20.9 months compared with 11.9 months in the AI arm (hazard ratio [HR], 0.58 [95% CI, 0.43 to 0.76]). The median OS was not reached in the combination arm and was 45.1 months in the AI arm (HR, 0.58 [95% CI, 0.37 to 0.93]). The most common adverse events were palmar-plantar erythrodysesthesia and peripheral neuropathy; grade 3 events occurred in 15.1% of the patients receiving combination treatment.

CONCLUSION
The MECCA trial demonstrated a significant improvement in PFS and OS with first-line metronomic capecitabine plus AI compared with AI alone in patients with hormone receptor-positive+/HER2-negative MBC. Both treatment arms exhibited tolerable safety profiles consistent with previous reports.
Correlated catalyst in quantum thermodynamics
Authors: Shiraishi Naoto 
Published: January 2025

Abstract
In this short review article, we present recent progress in quantum thermodynamics in the framework with a correlated catalyst. We examine two key properties of thermal operations, the Gibbs-preserving property and the covariant property. The state convertibility of a Gibbs-preserving operation is fully characterized by the second law of thermodynamics with the nonequilibrium free energy. The state convertibility of a covariant operation is shown to be free as long as an initial state has finite coherence. We finally show that these two findings can be combined in the enhanced thermal operation (covariant Gibbs-preserving operation).
Cushing Disease Clinical Phenotype and Tumor Behavior Vary With Age: Diagnostic and Perioperative Implications
Authors: Salcedo-Sifuentes Jorge Eduardo , Shih Ryan , Heaney Anthony P , Bergsneider Marvin , Wang Marilene B , Donangelo Ines , Lee Jivianne , Delery William , Karsy Michael , Kshettry Varun R , Yuen Kevin C J , Evans James J , Barkhoudarian Garni , Pacione Donato R , Gardner Paul A , Fernandez-Miranda Juan C , Benjamin Carolina , Zada Gabriel , Rennert Robert C , Silverstein Julie M , Chicoine Michael R , Kim Jiyoon , Li Gang , Little Andrew S , Kim Won 
Published: January 2025

Abstract

Context
Little is known about presenting clinical characteristics, tumor biology, and surgical morbidity of Cushing disease (CD) with aging.

Objective
Using a large multi-institutional data set, we assessed diagnostic and prognostic significance of age in CD through differences in presentation, laboratory results, tumor characteristics, and postoperative outcomes.

Methods
Data from the Registry of Adenomas of the Pituitary and Related Disorders (RAPID) were reviewed for patients with CD treated with transsphenoidal tumor resection at 11 centers between 2003 and 2023. Outcomes assessed included comorbidities, presenting features, preoperative endocrine evaluations, perioperative characteristics, postoperative endocrine laboratory values, and complications.

Results
Of the 608 patients evaluated, 496 (81.6%) were female; median age at surgery was 44 years (range, 10-78 years). Increasing age was associated with increasing comorbidities, frailty, rates of postoperative thromboembolic disease, Knosp grade, tumor size, and postoperative cortisol and adrenocorticotropin nadirs. Conversely, increasing age was associated with decreased hallmark CD features, preoperative 24-hour urinary free cortisol, Ki-67 indices, and arginine vasopressin deficiency. Younger patients presented more frequently with weight gain, facial rounding/plethora, abdominal striae, hirsutism, menstrual irregularities, dorsocervical fat pad, and acne. Obstructive sleep apnea and infections were more common with increasing age.

Conclusion
There are age-dependent differences in clinical presentation, tumor behavior, and postoperative outcomes in patients with CD. Compared to younger patients, older patients present with a less classic phenotype characterized by fewer hallmark features, more medical comorbidities, and larger tumors. Notably, age-related differences suggest a more indolent tumor behavior in older patients, potentially contributing to delayed diagnosis and increased perioperative risk. These findings underscore the need for tailored diagnostic and therapeutic approaches across age groups, with a focus on managing long-term comorbidities and optimizing surgical outcomes.
Positive autoregulation of Sox17 is necessary for gallbladder and extrahepatic bile duct formation
Authors: Trinh Linh T. , Finnel Ryan R. , Osipovich Anna B. , Musselman Jessica R. , Sampson Leesa L. , Wright Christopher V. E. , Magnuson Mark A. 
Published: January 2025

ABSTRACT
Expression of SRY-box transcription factor 17 (Sox17) in the endodermal region caudal to the hepatic diverticulum during late gastrulation is necessary for hepato-pancreato-biliary system formation. Analysis of an allelic series of promoter-proximal mutations near the transcription start site (TSS) 2 of Sox17 in mouse has revealed that gallbladder (GB) and extrahepatic bile duct (EHBD) development is exquisitely sensitive to Sox17 expression levels. Deletion of a SOX17-binding cis-regulatory element in the TSS2 promoter impairs GB and EHBD development by reducing outgrowth of the nascent biliary bud. These findings reveal the existence of a SOX17-dependent autoregulatory loop that drives Sox17 expression above a critical threshold concentration necessary for GB and EHBD development to occur, and that minor impairments in Sox17 gene expression are sufficient to impair the expression of SOX17-regulated genes in the nascent GB and EHBD system, impairing or preventing development.
Abnormal H3K27me3 underlies degenerative spermatogonial stem cells in cryptorchid testis
Authors: Kuroha Kazushige , Dočkal Ivana , Radović Uroš , Nakajima Kuniko , Hoshi Ikue , Matsuda Shion , Kojitani Noriko , Ohbo Kazuyuki , Tomizawa Shin-ichi 
Published: January 2025

ABSTRACT
Cryptorchidism is the most frequent congenital defect in newborn males characterized by the absence of the testis from the scrotum. Approximately 90% of individuals with untreated bilateral cryptorchidism exhibit azoospermia due to defective spermatogenesis in the affected testis. Although abnormal spermatogonial stem cell maintenance or differentiation is suggested to cause germ cell degeneration in the cryptorchid testis, the underlying molecular mechanisms remain unclear. Here, we profiled spermatogonial epigenetic landscapes using surgically induced cryptorchid testis in the mouse. We show that cryptorchidism leads to alterations in local, but not global, H3K27me3 and H3K9me3 in undifferentiated spermatogonia. Of these, the loss of H3K27me3 was correlated with activation of developmental and proapoptotic pathway genes that are repressed by the polycomb machinery in germ cells. Cryptorchid spermatogonia exhibit an increase of the H3K27me3 demethylases KDM6A and KMD6B. Furthermore, we reveal that an increased temperature leads to Kdm6a/b upregulation in germline stem cells cultured in vitro. Thus, our study suggests that temperature-dependent histone demethylation may induce mRNA dysregulation due to the partial loss of H3K27me3 in spermatogonia.
Design an Automatic Water Tank Filling Tool Using NodeMCU Based on the Internet of Things
Authors: Hazbi Taufan Maulana , Ma'arif Alfian 
Published: January 2025

Drought is still common in Indonesia, especially in the prolonged dry season while the world's clean water reserves are only around 3%. Groundwater is a renewable natural resource, but overexploitation can cause problems such as sink holes, land subsidence, and seawater intrusion, therefore, the design of filling water tanks and automatic height meters is made as an effort to save water. these automatic water tank measurements use the Internet of Things method accessed through Blynk. An internet of things-based tool measurement system with a water level principle uses an ultrasonic HC-SR04 sensor to measure Blynk's integrated water level, using the Nodemcu ESP8266 microcontroller as the main control. The overall result of the design of the tool, the water topping up process is shown in units of percent, the ultrasonic sensor HC-SR04 displays the actual distance and water level to Blynk in cm.
Toward exploring noncontinuous-state dynamics based on pulse-modulated frequency-shifted laser feedback interferometry
Authors: Li Jie , Zhao Yunkun , Liu Jie , Liu Jianchu , Li Hongtao , Yu Qi , Lv Jialiang , Lu Liang 
Published: January 2025

An exhaustive study of the noncontinuous-state laser dynamics associated with the transient optical process is significant because it reveals the complex physical mechanisms and characteristics in nonlinear laser systems. In this study, in-depth theoretical interpretation and experimental verification of the noncontinuous-state dynamics in laser system are presented, based on developed pulse-modulated frequency-shifted laser feedback interferometry (LFI). By introducing external pulse modulation, we investigate the nonlinear time-of-flight dynamics and related photon behaviors evolution of the pulsed LFI system by observing the changes in effective interference time sequences for interference realization and attainable minimum feedback photon number of the signal under various modulated noncontinuous states. Implementation of the pulse-modulated LFI scheme should exceed the pulse overlapping time window limit of 1.93 μs to effectively extract and preserve the extracavity feedback photon information. Experiments reveal that the minimum feedback photon number of signals successfully measured by the pulsed LFI sensor is 0.067 feedback photons per Doppler cycle, exhibiting high sensitivity for extremely weak signal detection. Further, simultaneous measurement for velocity and distance of the moving object is performed to validate the feasibility and applicability of the pulsed LFI. The system can successfully achieve large-range simultaneous measurements within the velocity range of 73.5−612.6  mm/s, over a distance of 25.5 km. This work opens the way to unexplored frontiers of pulsed LFI to fill the research gap in noncontinuous laser dynamics in this field, showcasing diverse and wide-ranging applications in the realm of integrated sensing, remote monitoring, and positioning and navigation.
Barriers and facilitators to implementing comprehensive sex education in Texas public schools: A qualitative study
Authors: Holt Lauren , Janek Sarah , Yamey Gavin 
Published: January 2025

Introduction
In Texas, the adolescent birth rate is higher than the national average and STIs have steadily increased over the last decade. Sex education is not mandated in Texas and the majority of public schools provide an abstinence-based sex education. Comprehensive sexuality education (CSE) programs are widely endorsed by national and global health organizations and research has shown that they are more effective in reducing poor sexual health outcomes than abstinence-based programs. The purpose of this study is to identify barriers and facilitators to implementing CSE at local and state levels in Texas.

Methods
Qualitative study design consisting of ten semi-structured interviews with eleven key informants (n = 11) conducted in 2021.

Results
Three barriers- ideological opposition to CSE, discrimination against LGBTQ+ people, myths and misconceptions about CSE- and two facilitators- champions, collaboration with community stakeholders- to implementing CSE policy were identified.

Conclusion
Study findings provide insight into the opposition faced by sex education advocates, which often stems from myths and misperceptions of CSE content and the stigmatization of sexual and gender minoritized groups. Parents, youth, medical professionals, and academic researchers are instrumental in dispelling sex education myths and misperceptions and engaging with community stakeholders.
Influence of pre-processing criteria on analysis of accelerometry-based physical activity
Authors: Han Bing , Perez Lilian , Cohen Deborah A. , Seelam Rachana , Derose Kathryn P. 
Published: January 2025

Background
Accelerometers are widely adopted for physical activity (PA) measurement. Accelerometry data require pre-processing before entering formal statistical analyses. Many pre-processing criteria may influence PA outcomes and the processed sample, impacting results in subsequent statistical analyses.

Aim
To study the implications of pre-processing criteria for accelerometer data on outputs of interest in physical activity studies.

Methods
We used the ActiGraph hip-worn accelerometry data from 538 adult Latino participants. We studied four most important domains of pre-processing criteria (wear-time, minimum wear-time, intensity level, and modified bouts). We examined the true sample size in pre-processed data, the moderate-to-vigorous physical activity (MVPA) outcome, and regression coefficients of age and gender predicting MVPA.

Results
Many pre-processing criteria have minimum impact to the output of interest. However, requirements for minimum wear-time can have high influence on subsequent analyses for MVPA. High requirements for wear-time (e.g., minimum of 5 days with more than 12 hours of wear-time per day) lead to weakened statistical efficiency in estimating the relationship between potential predictors and the MVPA outcome. Intensity levels using vector magnitude triaxial counts yielded drastically different results than those using conventional vertical axis counts.

Conclusion
Moderate changes in minimum wear-time can yield notably different output data and subsequently influence analyses assessing the impacts of interventions on MVPA behaviors. Processed data using vector magnitude and conventional vertical axis counts are not directly comparable. Sensitivity analyses using alternative pre-processing scenarios are highly recommended to verify the robustness of analyses for accelerometry data.
Effects of fascial manipulation, vibration exercise, motor imagery, or neuro‐muscular electrical stimulation on the coagulation system: A pilot study
Authors: Cvirn Gerhard , Hawliczek Anna , Schlagenhauf Axel , Brix Bianca , Zalaudek Karin Schmid , Schwaminger Sebastian , Paar Margret , Wonisch Willibald , Wagner Thomas , Arko Ziva , Goswami Nandu 
Published: January 2025

AbstractAvailable evidence suggests that various medical/rehabilitation treatments evoke multiple effects on blood hemostasis. It was therefore the aim of our study to examine whether fascial manipulation, vibration exercise, motor imagery, or neuro‐muscular electrical stimulation can activate the coagulation system, and, thereby, expose patients to thrombotic risk. Ten healthy young subject were enrolled in the study. Blood samples were obtained pre and posttreatment. Besides standard laboratory methods, calibrated automated thrombography (CAT) and thrombelastometry (TEM) were used allowing sensitive detection of hyper‐ and hypocoagulable states. Application of fascial manipulation, motor imagery, or neuro‐muscular electrical stimulation had vitually no effect whereas a single bout of vibration exercise caused significant coagulation activation. For example, TEM‐derived coagulation times were significantly shortened (209 ± 34 vs. 187 ± 41 s, p = 0.0098) and CAT‐derived thrombin peaks were significantly higher (235 ± 88 vs. 268 ± 82 nM, p = 0.0020) in post compared with preexercise samples. Moreover, vibration exercise, motor imagery, and neuro‐muscular electrical stimulation caused significant plasma expansion (6.15%, 7.53%, and 3.88% plasma volume changes, respectively). We conclude that vibrational exercise apparently represents a potential procoagulant stimulus, and ongoing studies have to clarify whether VE should be applied particularly to patients with an elevated risk for thrombosis.
Crashworthiness of GFRP/aluminum hybrid square tubes under quasi-static compression and single/repeated impact
Authors: Zhang Liangliang , Li Chaojiang , Chen Yilong , Chen Yida , Su Zhihao , Wu Ye , Wu Qiulan , Wan Yun 
Published: January 2025

Abstract
Thin-walled structures comprised of fiber-reinforced polymer (FRP) composites and metal excel in achieving a balanced design in terms of material cost, weight savings, and mechanical performance. This study aims to explore the crushing characteristics and failure mechanism of square hollow aluminum tubes wrapped with glass FRP (GFRP) fabricated by vacuum-assisted resin infusion with six types of lay-up directions. Axial quasi-static compression and single/repeated low-velocity impact (LVI) are conducted to investigate their failure evolution and energy absorption properties, such as the specific energy absorption (SEA), mean crushing force (MCF), peak crushing force (PCF), and crushing force efficiency (CFE). The synergy among oblique, axial, and circumferential GFRP ply, which enhances strength and reduces out-of-plane deformation in the structure, is maximized by using the antisymmetric angle ply rather than the single angle ply. Under these three loading modes, the cases with a [0°/90°]2 lay-up have excellent crashworthiness indicators, including PCF, SEA, and MCF. Meanwhile, compared with the pure aluminum tube, both the SEA and CFE are improved simultaneously by up to 158% and 121% during the single LVI test. The study focuses on the influence of stacking configurations on crashworthiness and further explores the potential and application of such hybrid structures.
Green synthesis and characterization of CuO/ZnO nanocomposite using Musa acuminata leaf extract for cytotoxic studies on colorectal cancer cells (HCC2998)
Authors: Wong Yee Jin , Subramaniam Hemaroopini , Shing Wong Ling , Dhanapal Anto Cordelia Tanislaus Antony , Chan Yu Bin , Aminuzzaman Mohammod , Tey Lai-Hock , Janakiraman Ashok Kumar , Kayarohanam Saminathan , Djearamane Sinouvassane 
Published: January 2025

Abstract
Green synthesis has become an alternative to replace chemical synthesis in nanotechnology because of its low cost and toxicity. The synthesis of nanocomposite (NC) has attracted the attention of researchers, as its synergistic effect might enhance its effectiveness in anticancer to overcome multidrug resistance. In this study, copper oxide/zinc oxide (CuO/ZnO) NC was green synthesized from the crude extract of Musa acuminata leaves with Zn(NO3)2·6H2O and Cu(NO3)2·3H2O as precursors. CuO/ZnO NC was characterized via UV-Vis analysis with a peak detected at 365 nm with a bandgap energy of 3.43 eV. Field emission scanning electron microscopy analysis showed an agglomerated, irregular shape with a size ranging from 31.8 to 85.7 nm. X-ray diffraction analysis depicted the crystallite size of 24.78 nm with hexagonal wurtzite of ZnO and monoclinic of CuO. Fourier transform infrared spectroscopy analysis showed the presence of functional groups, including hydroxyl groups, carbonyl groups, amines, alkanes, aromatic amines, Cu–O, and Zn–O. The cytotoxic effect of CuO/ZnO NC toward the colorectal cancer cells (HCC2998) was evaluated by the MTT assay and found to be dose-dependent. The results showed a significant cell mortality at 100 µg·mL−1 CuO/ZnO NC with 45.79% cell death at 24 h. The findings of the present study suggest the potential of CuO/ZnO NC to be utilized as an anticancer agent.
Introduction to the special issue
Authors: Jocuns Andrew , de Groot Freek Olaf 
Published: January 2025

Abstract
This special issue of Multimodal Communication is devoted to seven papers studying social interaction at the intersection of multimodality, multilingualism and identity. The goal of this special issue is to provide a platform to discuss how this intersection enables us to gain a better understanding of multimodal and multilingual practices in action as well as critically engaging with the current theories in the field that provide the lens for us to do so.
Coupled acoustoplasmonic resonators: the role of geometrical symmetries
Authors: Castillo López de Larrinzar Beatriz , García Jorge M. , Xiang Chushuang , Lanzillotti-Kimura Norberto D. , García-Martín Antonio 
Published: January 2025

Abstract
Acoustoplasmonic resonators, such as nanobars and crosses, are efficient acousto-optical transducers. The excitation of mechanical modes in these structures strongly depends on the spatial profile of the eigenmodes of the resonator. Using a system of two identical gold elongated bars placed on a silicon dioxide substrate, we examine how breaking mirror symmetries affects the optical and acoustic properties to provide insights in the design of acoustoplasmonic metasurfaces for nonsymmetric acousto-optical transducers. Our findings show that the absence of mirror symmetries affects differently the optical and nanomechanical response. Broken mirror symmetries not only couple nanomechanical modes existing in single bars but introduce new torsional resonant modes.