bluuebunny/crossref_metadata_2025_split huggingface dataset:
Head Injury Exposure in Veterans Presenting to Memory Disorders Clinic: An Observational Study of Clinical Characteristics and Relationship of Event-Related Potentials and Imaging Markers
Authors: Turk Katherine W. , Marin Anna , Schiloski Kylie A. , Vives-Rodriguez Ana L. , Uppal Prayerna , Suh Cheongmin , Dwyer Brigid , Palumbo Rocco , Budson Andrew E. 
Published: June 2021

Objective: Traumatic brain injury (TBI) and repetitive head impacts (RHI) related to blasts or contact sports are commonly reported among military service members. However, the clinical implications of remote TBI and RHI in veterans remains a challenge when evaluating older veterans at risk of neurodegenerative conditions including Alzheimer's disease (AD) and Chronic Traumatic Encephalopathy (CTE). This study aimed to test the hypothesis that veterans in a memory disorders clinic with remote head injury would be more likely to have neurodegenerative clinical diagnoses, increased rates of amyloid PET positivity, higher prevalence of cavum septum pellucidi/vergae, and alterations in event-related potential (ERP) middle latency auditory evoked potentials (MLAEPs) and long latency ERP responses compared to those without head injuries.Methods: Older veterans aged 50–100 were recruited from a memory disorders clinic at VA Boston Healthcare system with a history of head injury (n = 72) and without head injury history (n = 52). Patients were classified as reporting prior head injury including TBI and/or RHI exposure based on self-report and chart review. Participants underwent MRI to determine presence/absence of cavum and an ERP auditory oddball protocol.Results: The head injury group was equally likely to have a positive amyloid PET compared to the non-head injury group. Additionally, the head injury group were less likely to have a diagnosis of a neurodegenerative condition than those without head injury. P200 target amplitude and MLAEP amplitudes for standard and target tones were decreased in the head injury group compared to the non-head injury group while P3b amplitude did not differ.Conclusions: Veterans with reported remote head injury evaluated in a memory disorders clinic were not more likely to have a neurodegenerative diagnosis or imaging markers of neurodegeneration than those without head injury. Decreased P200 target and MLAEP target and standard tone amplitudes in the head injury group may be relevant as potential diagnostic markers of remote head injury.
A Novel Inflammatory-Nutritional Prognostic Scoring System for Stage III Gastric Cancer Patients With Radical Gastrectomy Followed by Adjuvant Chemotherapy
Authors: Wang Nan , Xi Wenqi , Lu Sheng , Jiang Jinling , Wang Chao , Zhu Zhenglun , Yan Chao , Liu Jing , Zhang Jun 
Published: June 2021

PurposeThe present study was designed to explore the prognostic value of preoperative inflammatory and nutritional biomarkers in stage III gastric cancer (GC) patients with adjuvant chemotherapy and to develop a novel scoring system called the inflammatory-nutritional prognostic score (INPS).MethodsA total of 513 patients with pathological stage III GC undergoing radical gastrectomy followed by adjuvant chemotherapy from 2010 to 2017 were enrolled in the study. Clinicopathological characteristics and blood test parameters of individual patients were collected. The least absolute shrinkage and selection operator (LASSO) Cox regression model was used for feature selection to construct INPS. Survival curves were generated using the Kaplan-Meier method with log-rank tests. The nomogram was generated based on the result of the multivariate analysis using Cox’s proportional hazards model. The model was assessed by the concordance index (C-index) and was internally validated by bootstraps.ResultsAccording to the results of Lasso Cox regression and K-M survival curves, INPS was determined as follows: a low body mass index (BMI) (&lt;23 kg/m2), a low prealbumin (&lt;180 mg/L), a high neutrophil-lymphocyte ratio (NLR) (≥2.7), a high platelet-lymphocyte ratio (PLR) (≥209.4), a low lymphocyte-monocyte ratio (LMR) (&lt;2.8), and a low prognostic nutritional index (PNI) (&lt;45.1); each were scored as 1, and the remaining values were scored as 0. The individual scores were then summed up to construct the INPS and further divided into 4 groups: Low Risk (INPS 0); Low-medium Risk (INPS 1); High-medium Risk (INPS 2-4); and High Risk (INPS 5-6). In multivariate analysis, INPS was an independent predictor of overall survival (OS) in stage III GC, with the 5-year OS rates of 70.8%, 57.4%, 41.5%, and 30.6%, respectively. The nomogram based on INPS and other independent predictors (gender, pT stage, pN stage, lymphovascular invasion, and CEA level) showed good predicting performance with a C-index of 0.707, which was superior to the TNM stage alone (C-index 0.645, p=0.008) and was internally validated with the corrected C-index of 0.693.ConclusionPreoperative INPS was an independent prognostic factor of stage III GC patients with radical surgery followed by adjuvant chemotherapy. The nomogram based on INPS may serve as a simple and potential model in risk stratification and guiding treatment strategies in clinical practice.
Different Patient Subgroup Different Maintenance, Proteasome Inhibitors or Immunomodulators Maintenance for Newly Diagnosed Multiple Myeloma: A 7-Year Single-Center Data in China
Authors: Han Xiaoyan , Jin Chunxiang , Zheng Gaofeng , He Donghua , Zhao Yi , Li Yi , Wu Wenjun , Zheng Weiyan , Wei Guoqing , Zhang Enfan , Huang He , He Jingsong , Cai Zhen 
Published: June 2021

IntroductionWe analyzed different patient subgroups to determine optimal maintenance therapy in newly diagnosed multiple myeloma (NDMM) patients.MethodsA total of 226 NDMM patients in our center were included in the study. The characteristics, survival, and adverse reactions were compared among patients who received maintenance therapy or not, and patients who received proteasome inhibitors (PIs) or immunomodulators (IMiDs) maintenance. The survival of different maintenance durations of bortezomib-based regimens was also analyzed.ResultsThe maintenance therapy not only upgraded more patient responses (34.3 vs 13.3%, P = 0.006), but also significantly prolonged their progression-free survival (PFS) (median PFS: 41.1 vs 10.5 months, P &lt; 0.001) and overall survival (OS) (median OS: not reached vs 38.6 months, P &lt; 0.001). Compared with IMiDs, the PFS (median PFS: 43.7 vs 38.5 months, P = 0.034) and OS (median OS: not reached vs 78.5 months, P = 0.041) were both enhanced by PIs maintenance. Patients younger than 65 years who received PIs had a significantly prolonged OS (P = 0.032). Patients achieving only a partial response (PR) after induction and consolidation therapy had significantly longer PFS and OS after PIs maintenance compared to IMiDs (P = 0.007, 0.002). High-risk patients (ISS 2–3, DS 2–3, and RISS 2–3) given PIs maintenance benefit from a prolonged PFS (P = 0.002, 0.02, 0.06) and OS (P = 0.059, 0.047, 0.044, respectively) compared with IMiDs therapy. OS was significantly prolonged in patients who received ≥ 12 months of bortezomib-based maintenance therapy compared to those who were treated for &lt; 12 months (P &lt; 0.001), but no difference was observed in OS between patients who received 12 to 24 or ≥ 24 months of bortezomib-based maintenance therapy (P = 0.292).ConclusionPIs maintenance was superior to IMiDs in overall PFS and OS. The beneficial effect was most evident in patients achieving PR after induction and consolidation therapy, and in high-risk patients. Moreover, younger patients also benefited from PIs maintenance with an increased OS. A bortezomib-based maintenance therapy duration of 12 to 24 months after induction and consolidation therapy produced satisfactory OS.
Angiogenesis Inhibitors for Head and Neck Squamous Cell Carcinoma Treatment: Is There Still Hope?
Authors: Hyytiäinen Aini , Wahbi Wafa , Väyrynen Otto , Saarilahti Kauko , Karihtala Peeter , Salo Tuula , Al-Samadi Ahmed 
Published: June 2021

BackgroundHead and neck squamous cell carcinoma (HNSCC) carries poor survival outcomes despite recent progress in cancer treatment in general. Angiogenesis is crucial for tumour survival and progression. Therefore, several agents targeting the pathways that mediate angiogenesis have been developed. We conducted a systematic review to summarise the current clinical trial data examining angiogenesis inhibitors in HNSCC.MethodsWe carried out a literature search on three angiogenesis inhibitor categories—bevacizumab, tyrosine kinase inhibitors and endostatin—from Ovid MEDLINE, Cochrane Library, Scopus and ClinicalTrials.gov database.ResultsHere, we analysed 38 clinical trials, total of 1670 patients, investigating 12 angiogenesis inhibitors. All trials were in phase I or II, except one study in phase III on bevacizumab. Angiogenesis inhibitors were used as mono- and combination therapies together with radio-, chemo-, targeted- or immunotherapy. Among 12 angiogenesis inhibitors, bevacizumab was the most studied drug, included in 13 trials. Although bevacizumab appeared effective in various combinations, it associated with high toxicity levels. Endostatin and lenvatinib were well-tolerated and their anticancer effects appeared promising.ConclusionsMost studies did not show benefit of angiogenesis inhibitors in HNSCC treatment. Additionally, angiogenesis inhibitors were associated with considerable toxicity. However, some results appear encouraging, suggesting that further investigations of angiogenesis inhibitors, particularly in combination therapies, for HNSCC patients are warranted.Systematic Review RegistrationPROSPERO (https://www.crd.york.ac.uk/prospero/), identifier CRD42020157144.
A Repurposed Drug Screen Identifies Compounds That Inhibit the Binding of the COVID-19 Spike Protein to ACE2
Authors: Tsegay Kaleb B. , Adeyemi Christiana M. , Gniffke Edward P. , Sather D. Noah , Walker John K. , Smith Stephen E. P. 
Published: June 2021

Repurposed drugs that block the interaction between the SARS-CoV-2 spike protein and its receptor ACE2 could offer a rapid route to novel COVID-19 treatments or prophylactics. Here, we screened 2,701 compounds from a commercial library of drugs approved by international regulatory agencies for their ability to inhibit the binding of recombinant, trimeric SARS-CoV-2 spike protein to recombinant human ACE2. We identified 56 compounds that inhibited binding in a concentration-dependent manner, measured the IC50of binding inhibition, and computationally modeled the docking of the best inhibitors to the Spike-ACE2 binding interface. The best candidates were Thiostrepton, Oxytocin, Nilotinib, and Hydroxycamptothecin with IC50’s in the 4–9 μM range. These results highlight an effective screening approach to identify compounds capable of disrupting the Spike-ACE2 interaction, as well as identify several potential inhibitors of the Spike-ACE2 interaction.
Internet-Based Cognitive Behavioral Therapy for Psychological Distress Associated With the COVID-19 Pandemic: A Pilot Randomized Controlled Trial
Authors: Aminoff Victoria , Sellén Malin , Sörliden Elise , Ludvigsson Mikael , Berg Matilda , Andersson Gerhard 
Published: June 2021

Background: The COVID-19 pandemic has been associated with various negative psychological consequences. This is a challenge for the society as regular psychological services cannot be offered to the same extent as before the pandemic. In addition to the requirement of social distancing, there is a need to adjust psychological treatment components like exposure to avoid increasing the spread of the infection. Internet-delivered cognitive behavior therapy (ICBT) has an established evidence base for a range of psychiatric problems and has been suggested as one possible approach to deal with the situation. This study aimed to conduct a randomized controlled pilot trial during the summer of 2020 with a broad focus on psychological distress and a treatment approach that tailors the intervention based on symptom profile and preferences.Methods: Following the advertisement and interview, we included 52 participants with elevated levels of psychological distress. They were randomly allocated to either a 7-week-long individually tailored ICBT (n = 26) or a wait-list control condition (n = 26). Measures of depression and quality of life were used as primary outcomes. We also included secondary outcome measures of anxiety, insomnia, trauma, stress, anger, and alcohol use. For screening, we used the CoRonavIruS Health Impact Survey (CRISIS).Results: Overall moderate to large between-group effects were found at post-treatment in favor of the treatment on measures of both depression [Beck Depression Inventory (BDI); Cohens d = 0.63; Patient Health Questionnaire (PHQ-9): d = 0.62] and anxiety [Generalized Anxiety Disorder-7-item scale (GAD-7); d = 0.82]. This was also observed for stress symptoms [Perceived Stress Scale (PSS-14); d = 1.04]. No effects were seen on measures of quality of life, insomnia, symptoms of post-traumatic stress, and anger. There was an effect on alcohol use [Alcohol Use Disorder Identification Test (AUDIT); d = 0.54], which was not of clinical relevance.Conclusion: Individually tailored ICBT shows initial promise as a way to reduce psychological problems in association with the COVID-19 pandemic. A possible limitation was that the trial was conducted when the effects of the pandemic were decreasing and when fewer people were affected by the restrictions (e.g., the summer of 2020).
Contagious Health Risk and Precautionary Social Distancing
Authors: Giese Helge , Gamp Martina , Stok F. Marijn , Gaissmaier Wolfgang , Schupp Harald T. , Renner Britta 
Published: June 2021

BackgroundSince humans are social animals, social relations are incredibly important. However, in cases of contagious diseases such as the flu, social contacts also pose a health risk. According to prominent health behavior change theories, perceiving a risk for one’s health motivates precautionary behaviors. The “behavioral immune system” approach suggests that social distancing might be triggered as a precautionary, evolutionarily learned behavior to prevent transmitting contagious diseases through social contact. This study examines the link between personal risk perception for an infectious disease and precautionary behavior for disease-prevention in the context of social relationships.MethodsAt 2-week intervals during the first semester, 100 Psychology freshmen indicated their flu risk perception, whether they had been ill during the previous week, and their friendships within their freshmen network for eight time points.ResultsSocial network analysis revealed that participants who reported a high flu risk perception listed fewer friends (B = −0.10, OR = 0.91, p = 0.026), and were more likely to be ill at the next measuring point (B = 0.26, OR = 1.30, p = 0.005). Incoming friendship nominations increased the likelihood of illness (B = 0.14, OR = 1.15, p = 0.008), while the reduced number of friendship nominations only marginally decreased this likelihood (B = −0.07, OR = 0.93, p = 0.052).ConclusionIn accordance with the concept of a “behavioral immune system,” participants with high flu risk perception displayed a social precautionary distancing even when in an environment, in which the behavior was ineffective to prevent an illness.
Psychotropic Polypharmacy in the US Pediatric Population: A Methodologic Critique and Commentary
Authors: Zito Julie M. , Zhu Yue , Safer Daniel J. 
Published: June 2021

Background: Psychotropic concomitant medication use for the treatment of youth with emotional and behavioral disorders has grown significantly in the U.S. over the past 25 years. The use of pharmacy claims to analyze these trends requires the following: age of the selected population, overlapping days of use, and precision of the outcome itself. This review will also address the gaps in reporting of pediatric psychotropic polypharmacy.Methods: An electronic literature search was undertaken for the period 2000 through 2020 using keywords such as “pediatric,” “concomitant,” “polypharmacy,” “multiple medications,” and “concurrent psychotropic”; Relevant references in textbooks were also used. Only English language and U.S. studies were included, resulting in 35 inter-class studies.Results: Studies were organized into seven groups according to data sources and clinical topics: (1) population surveys; (2a) multi-state publicly insured populations; (2b) single/two state studies; (3) privately insured populations; (4) diagnosed populations; (5) foster care populations; (6) special settings. Across 20 years it is apparent that pediatric psychotropic polypharmacy affects substantially more children and adolescents today than had been the case. As many as 300,000 youth now receive 3 or more classes concomitantly. The duration of concomitant use is relatively long, e.g., 69–89% of annual medicated days. Finally, more adverse event reports were associated with 3-class compared with 2-class drug regimens.Discussion: Factors that contribute to the growth of pediatric psychotropic polypharmacy include: (1) predominance of the biological model in psychiatric practice; (2) invalid assumptions on efficacy of combinations, (3) limited professional awareness of metabolic and neurological adverse drug events, and (4) infrequent use of appropriate deprescribing.Conclusion: A review of publications documenting U.S. pediatric psychotropic polypharmacy written over the last 20 years supports the need to standardize the methodologies used. The design of population-based studies should maximize information on the number of youth receiving regimens of 3-, 4-, and 5 or more concomitant classes and the duration of such use. Next, far more post-marketing research is needed to address the effectiveness, safety and tolerability of complex drug regimens prescribed for youngsters.
Küldetésorientált vezetés: a szemléletváltás mint a hatékonyság záloga
Authors: Szabóné Szabó Andrea 
Published: June 2021

Napjaink változó biztonsági környezetében a minden értelemben és minden területen értelmezhető alkalmazkodás, a kihívásokra adott gyors és rugalmas válasz kiemelt fontosságú. Igazodva a hadviselést is befolyásoló körülményekhez, a Honvédelmi és Haderőfejlesztési Program kapcsán megújuló Magyar Honvédség hatékonyságának egyik alappillére a vezetési szemlélet átalakítása.
IDENTIFIKASI JENIS TEPUNG TERIGU PADA ROTI GORENG BERDASARKAN FITUR LBP DENGAN MENGGUNAKAN JARINGAN SARAF TIRUAN
Authors: Chandra B Leonardo , Gasim Gasim , Rusbandi Rusbandi 
Published: June 2021

Penelitian ini tentang mengidentifikasi jenis tepung terigu pada goreng dengan menggunakan metode jaringan saraf tiruan. Jenis tepung terigu yang digunakan adalah kunci biru,
sania, dan segitiga biru. Metode pengenalan yang digunakan adalah backpropagation . Hasil pengujian yang dilakukan menggunakan ukuran pixel 450x450px, jarak potret sejauh ±20 cm,
resolusi kamera 16MP, menggunakan data latih sebanyak 100 citra/jenis dan data uji sebanyak 80 citra/jenis serta dengan menggunakan ekstraksi ciri Local Binary Pattern maka didapatkan hasil
berupa tingkat akurasi sebesar 68,57%, presisi sebesar 53,33% dan recall sebesar 54,47%.
Perbandingan Algoritma Backpropagation Dan Support Vector Machine Pada Pengenalan Jenis Biji Jagung
Authors: Yunarto Yunarto , Pribadi Muhammad Rizky , Irsyad Hafiz 
Published: June 2021

Jagung termasuk tumbuhan biji-bijian seperti padi, gandum, sorgum yang dikonsumsisebagai sumber makanan pokok di Amerika dan beberapa wilayah di Indonesia seperti Madura,Nusa Tenggara Timur, Sulawesi dan Jawa Tengah. Jagung biji memiliki banyak jenis, makadari itulah jika jagung biji tersebut tercampur akan susah untuk dibedakan. Tujuan daripenelitian ini adalah untuk mengenali biji jagung tersebut. Jenis biji jagung yang digunakanadalah jagung merah pozole, jagung pipil, jagung putih dan jagung warna-warni yang difotomenggunakan camera 16MP dengan jarak pengambilan foto 10cm antara kamera dengan objekjagung. Metode pengenalan yang digunakan adalah algoritma backpropagation dan support
vector machine, sedangkan untuk ekstraksi fitur menggunakan metode GLCM(Gray Co-occurence Matrix) yang terdiri dari Contrast, energy, homogeneity, dan correlation. Pada
perhitungan dengan confusion matrix hasil tertinggi didapatkan pada algoritmabackpropagation dengan rata-rata accuracy 97,5, rata-rata precision 95% dan rata-rata recallsebesar 95,1% dibandingkan dengan algoritma support vector machine yang hanya mendapatrata-rata accuracy 97,1%, rata-rata precision 93,3% dan rata-rata recall sebesar 95%.
PENERAPAN METODE NAIVE BAYES DALAM MENENTUKAN PENGARUH KEAKTIFAN MAHASISWA BERRORGANISASI TERHADAP PRESENTASI BELAJAR
Authors: R. Saragih Debby Febriani , Tambunan Heru Satria , Hardinata Jaya Tata 
Published: June 2021

Didalam perkuliahan ada suatu kegiatan yang dilakukan mahasiswa diluar dari jam kuliah dalam rangka mengembangkan minat dan bakat. Organisasi tersebut diperlukan mahasiswa untuk mengembangkan dan mengasah kemampuan yang dimiliki. Dengan adanya organisasi tersebut mahasiswa yang mengikuti dapat memperoleh banyak manfaat, diantaranya membina sikap disiplin, percaya diri, menambah wawasan melatih komunikasi didepan umum yang dapat dijadikan bekal untuk meningkatkan presentasi belajar. Maka metode Naive Bayes ini, agar dapat mengetahui apakah keaktifan mahasiswa dalam mengikuti organisasi berperan penting terhadap presentasi belajar mahasiswa, mahasiswa diminta untuk mengisi kuesioner berkaitan dengan berpengaruh atau tidaknya keaktifan mahasiswa dalam mengikuti organisasi. Diharapkan penelitian ini dapat mengetahui pengaruh atau tidaknya Keaktifan Mahasiswa dalam Organisasi terhadap presentasi belajar mahasiswa, nantinya hasil output dari sistem ini dapat menjadi bahan evaluasi untuk perguruan tinggi.
PENGARUH SHELTER BERBEDA TERHADAP PERTUMBUHAN DAN SINTASAN CRABLET KEPITING RAJUNGAN (Portunus pelagicus)
Authors: Wahyuni Sri , Budi Sutia , Mardiana Mardiana 
Published: June 2021

Tujuan penelitian ini untuk mengetahui penggunaan shelter dalam meningkatkan kelulusan hidup dan menurunkan kanibalisme crablet rajungan (Portunus pelagicus). Penelitian ini di laksanakan selama 2 bulan di Balai Perikanan Budidaya Air Payau (BPBAP) Takalar. Salah satu upaya untuk mengurangi tingkat kanibalisme pada budidaya rajungan (Portunus pelagicus) adalah dengan pemberian shelter berupa Rumput laut Glacillaria, rumput sintetis, waring hitam. Rajungan (Portunus pelagicus) stadia crablet diperoleh dari BPBAP Jepara dengan berat awal 0.03 gram sedangkan berat akhir 0.64 gram, metode yang digunakan adalah rancangan acak lengkap dengan 4 perlakuan dan 3 ulangan. Hasil penelitian pengunaaan jenis shelter yang berbeda terhadap pertumbuhan mutlak dan panjang karapas yang bertujuan untuk mengurangi tingkat kanibalisme kepiting tidak berpengaruh nyata. Sedangkan hasil perhitungan sintasan Rajungan (Portunus pelagicus) dapat disimpulkan bahwa hasil penggunaan jenis shelter yang berbeda dapat berpengaruh nyata (P< 0,01)
The aim of this study was to determine the use of shelter in increasing survival and reducing cannibalism of small crab (Portunus pelagicus) crablets. ` This research was carried out for 2 months at the Center for Brackish Water Aquaculture (BPBAP) Takalar. One effort to reduce the level of cannibalism in crab cultivation (Portunus pelagicus) is to provide shelter in the form of Glacillaria seaweed, synthetic grass, black waring. Crayfish (Portunus pelagicus) crablet stage was obtained from BPBAP Jepara with an initial weight of 0.03 grams and a final weight of 0.64 grams. The method used was a completely randomized design with 4 treatments and 3 replications. The results of the study using different types of shelter on absolute growth and carapace length aimed at reducing the level of crab cannibalism did not have a significant effect. While the results of the calculation of the survival of the crab (Portunus pelagicus) can be concluded that the results of using different types of shelters can have a significant effect (P < 0.01)